The 'Complete TyrA sequences' curated and available below consist of entire reading frames that include any fusions or N-terminal or C-terminal extensions. The majority of all proteins consist of more than one domain, these being referred to as "Supradomains" [Vogel et al. 2004] The minimal functional unit for TyrA is the 'Catalytic-core supradomain', which herein is subdivided into a short N-terminal 'Pyridine nucleotide discriminator segment' and a following 'Cyclohexadienyl-substrate core segment'. The 'Catalytic-core supradomains' have been trimmed of all N-terminal and C-terminal extensions, including fusions.

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Tyrosine Biosynthesis

Complete TyrA Sequences

Catalytic-core domains

Pyridine nucleotide discriminator segment
• NAD⁺-specific
• NADP⁺-specific
• Broad specificity

Cyclohexadienyl-substrate core segment
• Arogenate-specific -- TyrAa
• Prephenate-specific -- TyrAp
• Broad specificity -- TyrAc
• Unknown specificity
  
  
TyrA pseudogenes