fig|340186.3.peg.3891
Escherichia coli E110019 (28-696/696)
MIVSA
SGYEKKL
T
NA
AA
S
VSVI
SQ
EE
LQ
S
S
-
Q-YH
DL
A
E
A
LR
S
-
V
E
GV
D
V
--E
S
GT
G
KT
G
-
G
L
E
ISIRGM
P
ASY
TL
------
ILIDG
-
-
------
VRQG
GS
S
D
V
T
PN
G
FSAM
N
T
GFM
PP
L
AA
IERIEV
I
RGP
M
S
T
LYG
S
D
A
M
GGVVNIIT
R
K
N
A
--------------
DK
W
LS
S
VN
A
GL
N
LQ
E
SN
K
W
---
G
----
NS
S
QF
NF
WSS
GPL
V
D
D
SVSL
Q
VR
G
STQ
Q
RQ
G
-
-
-------
SSVTSLSDTAA
T
R
I
PYPT
E
S-Q
N
Y
N
L
G
A
RL
--
D
WK
A
S
E
Q
D
V
L
WF
D
MDT
T
RQ
-----
---
R
YD
N
R
D
G
Q
LG
SL
TGG
-----------------
Y
D
R
T
L
R
Y
E
R
NKISAGYDHTFTF
G
-
TWKSYLN
W
NE
T
E
---------
N
KGRELVRSV
L
K
R
---
DKW
GL
A
G
QPR
-------
-
----
ELKE
S
NLILN
S
L
L
LT
P
L
G--ESH
L
V
T
V
G
G
E
F
QSS
S
MK
D
-------
-
------
-
--
-
G
VVLASTGETFRQ
K
SW
S
V
---
-
--
FAE
DEWH
LTD
A
L
A
L
T
AG
S
RY
--------
E
H
------------
HEQF
G
G
----------
H
F
SP
RAY
L
VWD
V
A
D
A
W
T
LK
G
G
VT
T
GYKAP
R
M
G
Q
------
L
HKGIS
G
VS-
--
GQ
G
KTN
L
-----
L
GN
P
DLKPE
E
S
V
S
Y
E
A
G
VYYDNPA
GL
N
A
N
VT
G
F
M
TD
FS
NKIV
S
-------
Y
S
INDNTNS
Y
V
N
S
GKAR
LH
G
V
E
F
A
GTL
P
L
WSE
D
VTLSL
N
Y
TW
T
-------
-R
SEQ
RD
GDN
K
G
A
----
P
LS
Y
T
PE
H
M
V
NA
K
L
N
W
QIT
E
EVASWLGA
R
YR
GK
-T
P
RFT
Q
NY
SSLS
AV
QKKVY
D
EK
G
EYLKA
W
T
V
V
DA
GLS
WK
M
T
D
---
A
L
T
L
NAA
V
N
NL
LN
K
D
Y
SDVS
L
YSA
G
K
---
STLY
AG
DYFQT
G
S
S
T
---
T
G
Y
VI
P
E
RNY
W
MS
L
N
YQ
F
fig|83334.1.peg.1414
Escherichia coli O157:H7 (28-696/696)
MIVSA
SGYEKKL
T
NA
AA
S
VSVI
SQ
EE
LQ
S
S
-
Q-YH
DL
A
E
A
LR
S
-
V
E
GV
D
V
--E
S
GT
G
KT
G
-
G
L
E
ISIRGM
P
ASY
TL
------
ILIDG
-
-
------
VRQG
GS
S
D
V
T
PN
G
FSAM
N
T
GFM
PP
L
AA
IERIEV
I
RGP
M
S
T
LYG
S
D
A
M
GGVVNIIT
R
K
N
A
--------------
DK
W
LS
S
VN
A
GL
N
LQ
E
SN
K
W
---
G
----
NS
S
QF
NF
WSS
GPL
V
D
D
SVSL
Q
VR
G
STQ
Q
RQ
G
-
-
-------
SSVTSLSDTAA
T
R
I
PYPT
E
S-Q
N
Y
N
L
G
A
RL
--
D
WK
A
S
E
Q
D
V
L
WF
D
MDT
T
RQ
-----
---
R
YD
N
R
D
G
Q
LG
SL
TGG
-----------------
Y
D
R
T
L
R
Y
E
R
NKISAGYDHTFTF
G
-
TWKSYLN
W
NE
T
E
---------
N
KGRELVRSV
L
K
R
---
DKW
GL
A
G
QPR
-------
-
----
ELKE
S
NLILN
S
L
L
LT
P
L
G--ESH
L
V
T
V
G
G
E
F
QSS
S
MK
D
-------
-
------
-
--
-
G
VVLASTGETFRQ
K
SW
S
V
---
-
--
FAE
DEWH
LTD
A
L
A
L
T
AG
S
RY
--------
E
H
------------
HEQF
G
G
----------
H
F
SP
RAY
L
VWD
V
A
D
A
W
T
LK
G
G
VT
T
GYKAP
R
M
G
Q
------
L
HKGIS
G
VS-
--
GQ
G
KTN
L
-----
L
GN
P
DLKPE
E
S
V
S
Y
E
A
G
VYYDNPA
GL
N
A
N
VT
G
F
M
TD
FS
NKIV
S
-------
Y
S
INDNTNS
Y
V
N
S
GKAR
LH
G
V
E
F
A
GTL
P
L
WSE
D
VTLSL
N
Y
TW
T
-------
-R
SEQ
RD
GDN
K
G
A
----
P
LS
Y
T
PE
H
M
V
NA
K
L
N
W
QIT
E
EVASWLGA
R
YR
GK
-T
P
RFT
Q
NY
SSLS
AV
QKKVY
D
EK
G
EYLKA
W
T
V
V
DA
GLS
WK
M
T
D
---
A
L
T
L
NAA
V
N
NL
LN
K
D
Y
SDVS
L
YSA
G
K
---
STLY
AG
DYFQT
G
S
S
T
---
T
G
Y
VI
P
E
RNY
W
MS
L
N
YQ
F
fig|155864.1.peg.1021
Escherichia coli O157:H7 EDL933 (28-696/696)
MIVSA
SGYEKKL
T
NA
AA
S
VSVI
SQ
EE
LQ
S
S
-
Q-YH
DL
A
E
A
LR
S
-
V
E
GV
D
V
--E
S
GT
G
KT
G
-
G
L
E
ISIRGM
P
ASY
TL
------
ILIDG
-
-
------
VRQG
GS
S
D
V
T
PN
G
FSAM
N
T
GFM
PP
L
AA
IERIEV
I
RGP
M
S
T
LYG
S
D
A
M
GGVVNIIT
R
K
N
A
--------------
DK
W
LS
S
VN
A
GL
N
LQ
E
SN
K
W
---
G
----
NS
S
QF
NF
WSS
GPL
V
D
D
SVSL
Q
VR
G
STQ
Q
RQ
G
-
-
-------
SSVTSLSDTAA
T
R
I
PYPT
E
S-Q
N
Y
N
L
G
A
RL
--
D
WK
A
S
E
Q
D
V
L
WF
D
MDT
T
RQ
-----
---
R
YD
N
R
D
G
Q
LG
SL
TGG
-----------------
Y
D
R
T
L
R
Y
E
R
NKISAGYDHTFTF
G
-
TWKSYLN
W
NE
T
E
---------
N
KGRELVRSV
L
K
R
---
DKW
GL
A
G
QPR
-------
-
----
ELKE
S
NLILN
S
L
L
LT
P
L
G--ESH
L
V
T
V
G
G
E
F
QSS
S
MK
D
-------
-
------
-
--
-
G
VVLASTGETFRQ
K
SW
S
V
---
-
--
FAE
DEWH
LTD
A
L
A
L
T
AG
S
RY
--------
E
H
------------
HEQF
G
G
----------
H
F
SP
RAY
L
VWD
V
A
D
A
W
T
LK
G
G
VT
T
GYKAP
R
M
G
Q
------
L
HKGIS
G
VS-
--
GQ
G
KTN
L
-----
L
GN
P
DLKPE
E
S
V
S
Y
E
A
G
VYYDNPA
GL
N
A
N
VT
G
F
M
TD
FS
NKIV
S
-------
Y
S
INDNTNS
Y
V
N
S
GKAR
LH
G
V
E
F
A
GTL
P
L
WSE
D
VTLSL
N
Y
TW
T
-------
-R
SEQ
RD
GDN
K
G
A
----
P
LS
Y
T
PE
H
M
V
NA
K
L
N
W
QIT
E
EVASWLGA
R
YR
GK
-T
P
RFT
Q
NY
SSLS
AV
QKKVY
D
EK
G
EYLKA
W
T
V
V
DA
GLS
WK
M
T
D
---
A
L
T
L
NAA
V
N
NL
LN
K
D
Y
SDVS
L
YSA
G
K
---
STLY
AG
DYFQT
G
S
S
T
---
T
G
Y
VI
P
E
RNY
W
MS
L
N
YQ
F
fig|155864.1.peg.1429
Escherichia coli O157:H7 EDL933 (28-696/696)
MIVSA
SGYEKKL
T
NA
AA
S
VSVI
SQ
EE
LQ
S
S
-
Q-YH
DL
A
E
A
LR
S
-
V
E
GV
D
V
--E
S
GT
G
KT
G
-
G
L
E
ISIRGM
P
ASY
TL
------
ILIDG
-
-
------
VRQG
GS
S
D
V
T
PN
G
FSAM
N
T
GFM
PP
L
AA
IERIEV
I
RGP
M
S
T
LYG
S
D
A
M
GGVVNIIT
R
K
N
A
--------------
DK
W
LS
S
VN
A
GL
N
LQ
E
SN
K
W
---
G
----
NS
S
QF
NF
WSS
GPL
V
D
D
SVSL
Q
VR
G
STQ
Q
RQ
G
-
-
-------
SSVTSLSDTAA
T
R
I
PYPT
E
S-Q
N
Y
N
L
G
A
RL
--
D
WK
A
S
E
Q
D
V
L
WF
D
MDT
T
RQ
-----
---
R
YD
N
R
D
G
Q
LG
SL
TGG
-----------------
Y
D
R
T
L
R
Y
E
R
NKISAGYDHTFTF
G
-
TWKSYLN
W
NE
T
E
---------
N
KGRELVRSV
L
K
R
---
DKW
GL
A
G
QPR
-------
-
----
ELKE
S
NLILN
S
L
L
LT
P
L
G--ESH
L
V
T
V
G
G
E
F
QSS
S
MK
D
-------
-
------
-
--
-
G
VVLASTGETFRQ
K
SW
S
V
---
-
--
FAE
DEWH
LTD
A
L
A
L
T
AG
S
RY
--------
E
H
------------
HEQF
G
G
----------
H
F
SP
RAY
L
VWD
V
A
D
A
W
T
LK
G
G
VT
T
GYKAP
R
M
G
Q
------
L
HKGIS
G
VS-
--
GQ
G
KTN
L
-----
L
GN
P
DLKPE
E
S
V
S
Y
E
A
G
VYYDNPA
GL
N
A
N
VT
G
F
M
TD
FS
NKIV
S
-------
Y
S
INDNTNS
Y
V
N
S
GKAR
LH
G
V
E
F
A
GTL
P
L
WSE
D
VTLSL
N
Y
TW
T
-------
-R
SEQ
RD
GDN
K
G
A
----
P
LS
Y
T
PE
H
M
V
NA
K
L
N
W
QIT
E
EVASWLGA
R
YR
GK
-T
P
RFT
Q
NY
SSLS
AV
QKKVY
D
EK
G
EYLKA
W
T
V
V
DA
GLS
WK
M
T
D
---
A
L
T
L
NAA
V
N
NL
LN
K
D
Y
SDVS
L
YSA
G
K
---
STLY
AG
DYFQT
G
S
S
T
---
T
G
Y
VI
P
E
RNY
W
MS
L
N
YQ
F
fig|478005.5.peg.1702
Escherichia coli O157:H7 str. EC4486 (28-696/696)
MIVSA
SGYEKKL
T
NA
AA
S
VSVI
SQ
EE
LQ
S
S
-
Q-YH
DL
A
E
A
LR
S
-
V
E
GV
D
V
--E
S
GT
G
KT
G
-
G
L
E
ISIRGM
P
ASY
TL
------
ILIDG
-
-
------
VRQG
GS
S
D
V
T
PN
G
FSAM
N
T
GFM
PP
L
AA
IERIEV
I
RGP
M
S
T
LYG
S
D
A
M
GGVVNIIT
R
K
N
A
--------------
DK
W
LS
S
VN
A
GL
N
LQ
E
SN
K
W
---
G
----
NS
S
QF
NF
WSS
GPL
V
D
D
SVSL
Q
VR
G
STQ
Q
RQ
G
-
-
-------
SSVTSLSDTAA
T
R
I
PYPT
E
S-Q
N
Y
N
L
G
A
RL
--
D
WK
A
S
E
Q
D
V
L
WF
D
MDT
T
RQ
-----
---
R
YD
N
R
D
G
Q
LG
SL
TGG
-----------------
Y
D
R
T
L
R
Y
E
R
NKISAGYDHTFTF
G
-
TWKSYLN
W
NE
T
E
---------
N
KGRELVRSV
L
K
R
---
DKW
GL
A
G
QPR
-------
-
----
ELKE
S
NLILN
S
L
L
LT
P
L
G--ESH
L
V
T
V
G
G
E
F
QSS
S
MK
D
-------
-
------
-
--
-
G
VVLASTGETFRQ
K
SW
S
V
---
-
--
FAE
DEWH
LTD
A
L
A
L
T
AG
S
RY
--------
E
H
------------
HEQF
G
G
----------
H
F
SP
RAY
L
VWD
V
A
D
A
W
T
LK
G
G
VT
T
GYKAP
R
M
G
Q
------
L
HKGIS
G
VS-
--
GQ
G
KTN
L
-----
L
GN
P
DLKPE
E
S
V
S
Y
E
A
G
VYYDNPA
GL
N
A
N
VT
G
F
M
TD
FS
NKIV
S
-------
Y
S
INDNTNS
Y
V
N
S
GKAR
LH
G
V
E
F
A
GTL
P
L
WSE
D
VTLSL
N
Y
TW
T
-------
-R
SEQ
RD
GDN
K
G
A
----
P
LS
Y
T
PE
H
M
V
NA
K
L
N
W
QIT
E
EVASWLGA
R
YR
GK
-T
P
RFT
Q
NY
SSLS
AV
QKKVY
D
EK
G
EYLKA
W
T
V
V
DA
GLS
WK
M
T
D
---
A
L
T
L
NAA
V
N
NL
LN
K
D
Y
SDVS
L
YSA
G
K
---
STLY
AG
DYFQT
G
S
S
T
---
T
G
Y
VI
P
E
RNY
W
MS
L
N
YQ
F
fig|199310.1.peg.3528
Escherichia coli CFT073 (28-696/696)
MIVSA
SGYEKKL
T
NA
AA
S
VSVI
SQ
EE
LQ
S
S
-
Q-YH
DL
A
E
A
LR
S
-
V
E
GV
D
V
--E
S
GT
G
KT
G
-
G
L
E
ISIRGM
P
ASY
TL
------
ILIDG
-
-
------
VRQG
GS
S
D
V
T
PN
G
FSAM
N
T
GFM
PP
L
AA
IERIEV
I
RGP
M
S
T
LYG
S
D
A
M
GGVVNIIT
R
K
N
A
--------------
DK
W
LS
S
VN
A
GL
N
LQ
E
SN
K
W
---
G
----
NS
S
QF
NF
WSS
GPL
V
D
D
SVSL
Q
VR
G
STQ
Q
RQ
G
-
-
-------
SSVTSLSDTAA
T
R
I
PYPT
E
S-Q
N
Y
N
L
G
A
RL
--
D
WK
A
S
E
Q
D
V
L
WF
D
MDT
T
RQ
-----
---
R
YD
N
R
D
G
Q
LG
SL
TGG
-----------------
Y
D
R
T
L
R
Y
E
R
NKISAGYDHTFTF
G
-
TWKSYLN
W
NE
T
E
---------
N
KGRELVRSV
L
K
R
---
DKW
GL
A
G
QPR
-------
-
----
ELKE
S
NLILN
S
L
L
LT
P
L
G--ESH
L
V
T
V
G
G
E
F
QSS
S
MK
D
-------
-
------
-
--
-
G
VVLASTGETFRQ
K
SW
S
V
---
-
--
FAE
DEWH
LTD
A
L
A
L
T
AG
S
RY
--------
E
H
------------
HEQF
G
G
----------
H
F
SP
RAY
L
VWD
V
A
D
A
W
T
LK
G
G
VT
T
GYKAP
R
M
G
Q
------
L
HKGIS
G
VS-
--
GQ
G
KTN
L
-----
L
GN
P
N
LKPE
E
S
V
S
Y
E
A
G
VYYDNPA
GL
N
A
N
VT
G
F
M
TD
FS
NKIV
S
-------
Y
S
INDNTNS
Y
V
N
S
GKAR
LH
G
V
E
F
A
GTL
P
L
WSE
D
VTLSL
N
Y
TW
T
-------
-R
SEQ
RD
GDN
K
G
A
----
P
LS
Y
T
PE
H
M
V
NA
K
L
N
W
QIT
E
EVASWLGA
R
YR
GK
-T
P
RFT
Q
NY
SSLS
AV
QKKVY
D
EK
G
EYLKA
W
T
V
V
DA
GLS
WK
M
T
D
---
A
L
T
L
NAA
V
N
NL
LN
K
D
Y
SDVS
L
YSA
G
K
---
STLY
AG
DYFQT
G
S
S
T
---
T
G
Y
VI
P
E
RNY
W
MS
L
N
YQ
F
fig|655817.3.peg.3439
Escherichia coli ABU 83972 (28-696/696)
MIVSA
SGYEKKL
T
NA
AA
S
VSVI
SQ
EE
LQ
S
S
-
Q-YH
DL
A
E
A
LR
S
-
V
E
GV
D
V
--E
S
GT
G
KT
G
-
G
L
E
ISIRGM
P
ASY
TL
------
ILIDG
-
-
------
VRQG
GS
S
D
V
T
PN
G
FSAM
N
T
GFM
PP
L
AA
IERIEV
I
RGP
M
S
T
LYG
S
D
A
M
GGVVNIIT
R
K
N
A
--------------
DK
W
LS
S
VN
A
GL
N
LQ
E
SN
K
W
---
G
----
NS
S
QF
NF
WSS
GPL
V
D
D
SVSL
Q
VR
G
STQ
Q
RQ
G
-
-
-------
SSVTSLSDTAA
T
R
I
PYPT
E
S-Q
N
Y
N
L
G
A
RL
--
D
WK
A
S
A
Q
D
V
L
WF
D
MDT
T
RQ
-----
---
R
YD
N
R
D
G
Q
LG
SL
TGG
-----------------
Y
D
R
T
L
R
Y
E
R
NKISAGYDHTFTF
G
-
TWKSYLN
W
NE
T
E
---------
N
KGRELVRSV
L
K
R
---
DKW
GL
A
G
QPR
-------
-
----
ELKE
S
NLILN
S
L
L
LT
P
L
G--ESH
L
V
T
V
G
G
E
F
QSS
S
MK
D
-------
-
------
-
--
-
G
VVLASTGETFRQ
K
SW
S
V
---
-
--
FAE
DEWH
LTD
A
L
A
L
T
V
G
S
RY
--------
E
H
------------
HEQF
G
G
----------
H
F
SP
RAY
L
VWD
V
A
D
A
W
T
LK
G
G
VT
T
GYKAP
R
M
G
Q
------
L
HKGIS
G
VS-
--
GQ
G
KTN
L
-----
L
GN
P
DLKPE
E
S
V
S
Y
E
A
G
VYYDNPA
GL
N
A
N
VT
G
F
M
TD
FS
NKIV
S
-------
Y
S
INDNTNS
Y
V
N
S
GKAR
LH
G
V
E
F
A
GTL
P
L
WSE
D
VTLSL
N
Y
TW
T
-------
-R
SEQ
RD
GDN
K
G
A
----
P
LS
Y
T
PE
H
M
V
NA
K
L
N
W
QIT
E
EVASWLGA
R
YR
GK
-T
P
RFT
Q
NY
SSLS
AV
QKKVY
D
EK
G
EYLKA
W
T
V
V
DA
GLS
WK
M
T
D
---
A
L
T
L
NAA
V
N
NL
LN
K
D
Y
SDVS
L
YSA
G
K
---
STLY
AG
DYFQT
G
S
S
T
---
T
G
Y
VI
P
E
RNY
W
MS
L
N
YQ
F
fig|1040638.4.peg.989
Escherichia coli O104:H4 str. LB226692
MIVSA
SGYEKKL
T
NA
AA
S
VSVI
SQ
EE
LQ
S
S
-
Q-YH
DL
A
E
A
LR
S
-
V
E
GV
D
V
--E
S
GT
G
KT
G
-
G
L
E
ISIRGM
P
ASY
TL
------
ILIDG
-
-
------
VRQG
GG
S
D
V
T
PN
G
FSAM
N
T
GFM
PP
L
AA
IERIEV
I
RGP
M
S
T
LYG
S
D
A
M
GGVVNIIT
R
K
N
A
--------------
DK
W
LS
S
VN
A
GL
N
LQ
E
SN
K
W
---
G
----
NS
S
QF
NF
WSS
GPL
V
D
D
SVSL
Q
VR
G
STQ
Q
RQ
G
-
-
-------
SSVTSLSDTAA
T
R
I
PYPT
E
S-Q
N
Y
N
L
G
A
RL
--
D
WK
A
S
E
Q
D
V
L
WF
D
MDT
T
RQ
-----
---
R
YD
N
R
D
G
Q
LG
SL
TGG
-----------------
Y
D
R
T
L
R
Y
E
R
NKISAGYDHTFTF
G
-
TWKSYLN
W
NE
T
E
---------
N
KGRELVRSV
L
K
R
---
DKW
GL
A
G
QPR
-------
-
----
ELKE
S
NLILN
S
L
L
LT
P
L
G--ESH
L
V
T
V
G
G
E
F
QSS
S
MK
D
-------
-
------
-
--
-
G
VVLASTGETFRQ
K
SW
S
V
---
-
--
FAE
DEWH
LTD
A
L
A
L
T
AG
S
RY
--------
E
H
------------
HEQF
G
G
----------
H
F
SP
RAY
L
VWD
V
A
D
A
W
T
LK
G
G
VT
T
GYKAP
R
M
G
Q
------
L
HKGIS
G
VS-
--
GQ
G
KTN
L
-----
L
GN
P
DLKPE
E
S
V
S
Y
E
A
G
VYYDNPA
GL
N
A
N
VT
G
F
M
TD
FS
NKIV
S
-------
Y
S
INDNTNS
Y
V
N
S
GKAR
LH
G
V
E
F
A
GTL
P
L
WSE
D
VTLSL
N
Y
TW
T
-------
-R
SEQ
RD
GDN
K
G
A
----
P
LS
Y
T
PE
H
M
V
NA
K
L
N
W
QIT
E
EVASWLGA
R
YR
GK
-T
P
RFT
Q
NY
SSLS
AV
QKKVY
D
EK
G
EYLKA
W
T
V
V
DA
GLS
WK
M
T
D
---
A
L
T
L
NAA
V
N
NL
LN
K
D
Y
SDVS
L
YSA
G
K
---
STLY
AG
DYFQT
G
S
S
T
---
T
G
Y
VI
P
E
RNY
W
MS
L
N
YQ
F
fig|6666666.5357.peg.4490
Escherichia coli TY-2482
MIVSA
SGYEKKL
T
NA
AA
S
VSVI
SQ
EE
LQ
S
S
-
Q-YH
DL
A
E
A
LR
S
-
V
E
GV
D
V
--E
S
GT
G
KT
G
-
G
L
E
ISIRGM
P
ASY
TL
------
ILIDG
-
-
------
VRQG
GG
S
D
V
T
PN
G
FSAM
N
T
GFM
PP
L
AA
IERIEV
I
RGP
M
S
T
LYG
S
D
A
M
GGVVNIIT
R
K
N
A
--------------
DK
W
LS
S
VN
A
GL
N
LQ
E
SN
K
W
---
G
----
NS
S
QF
NF
WSS
GPL
V
D
D
SVSL
Q
VR
G
STQ
Q
RQ
G
-
-
-------
SSVTSLSDTAA
T
R
I
PYPT
E
S-Q
N
Y
N
L
G
A
RL
--
D
WK
A
S
E
Q
D
V
L
WF
D
MDT
T
RQ
-----
---
R
YD
N
R
D
G
Q
LG
SL
TGG
-----------------
Y
D
R
T
L
R
Y
E
R
NKISAGYDHTFTF
G
-
TWKSYLN
W
NE
T
E
---------
N
KGRELVRSV
L
K
R
---
DKW
GL
A
G
QPR
-------
-
----
ELKE
S
NLILN
S
L
L
LT
P
L
G--ESH
L
V
T
V
G
G
E
F
QSS
S
MK
D
-------
-
------
-
--
-
G
VVLASTGETFRQ
K
SW
S
V
---
-
--
FAE
DEWH
LTD
A
L
A
L
T
AG
S
RY
--------
E
H
------------
HEQF
G
G
----------
H
F
SP
RAY
L
VWD
V
A
D
A
W
T
LK
G
G
VT
T
GYKAP
R
M
G
Q
------
L
HKGIS
G
VS-
--
GQ
G
KTN
L
-----
L
GN
P
DLKPE
E
S
V
S
Y
E
A
G
VYYDNPA
GL
N
A
N
VT
G
F
M
TD
FS
NKIV
S
-------
Y
S
INDNTNS
Y
V
N
S
GKAR
LH
G
V
E
F
A
GTL
P
L
WSE
D
VTLSL
N
Y
TW
T
-------
-R
SEQ
RD
GDN
K
G
A
----
P
LS
Y
T
PE
H
M
V
NA
K
L
N
W
QIT
E
EVASWLGA
R
YR
GK
-T
P
RFT
Q
NY
SSLS
AV
QKKVY
D
EK
G
EYLKA
W
T
V
V
DA
GLS
WK
M
T
D
---
A
L
T
L
NAA
V
N
NL
LN
K
D
Y
SDVS
L
YSA
G
K
---
STLY
AG
DYFQT
G
S
S
T
---
T
G
Y
VI
P
E
RNY
W
MS
L
N
YQ
F
fig|562.371.peg.1637
Escherichia coli 1044A
MIVSA
SGYEKKL
T
NA
AA
S
VSVI
SQ
EE
LQ
S
S
-
Q-YH
DL
A
E
A
LR
S
-
V
E
GV
D
V
--E
S
GT
G
KT
G
-
G
L
E
ISIRGM
P
ASY
TL
------
ILIDG
-
-
------
VRQG
GS
S
D
V
T
PN
G
FSAM
N
T
GFM
PP
L
AA
IERIEV
I
RGP
M
S
T
LYG
S
D
A
M
GGVVNIIT
R
K
N
A
--------------
DK
W
LS
S
VN
A
GL
N
LQ
E
SN
K
W
---
G
----
NS
S
QF
NF
WSS
GPL
V
D
D
SVSL
Q
VR
G
STQ
Q
RQ
G
-
-
-------
SSVTSLSDTAA
T
R
I
PYPT
E
S-Q
N
Y
N
L
G
A
RL
--
D
WK
A
S
E
Q
D
V
L
WF
D
MDT
T
RQ
-----
---
R
YD
N
R
D
G
Q
LG
SL
TGG
-----------------
Y
D
R
T
L
R
Y
E
R
NKISAGYDHTFTF
G
-
TWKSYLN
W
NE
T
E
---------
N
KGRELVRSV
L
K
R
---
DKW
GL
A
G
QPR
-------
-
----
ELKE
S
NLILN
S
L
L
LT
P
L
G--ESH
L
V
T
V
G
G
E
F
QSS
S
MK
D
-------
-
------
-
--
-
G
VVLASTGETFRQ
K
SW
S
V
---
-
--
FAE
DEWH
LTD
A
L
A
L
T
AG
S
RY
--------
E
H
------------
HEQF
G
G
----------
H
F
SP
RAY
L
VWD
V
A
D
A
W
T
LK
G
G
VT
T
GYKAP
R
M
G
Q
------
L
HKGIS
G
VS-
--
GQ
G
KTN
L
-----
L
GN
P
DLKPE
E
S
V
S
Y
E
A
G
VYYDNPA
GL
N
A
N
VT
G
F
M
TD
FS
NKIV
S
-------
Y
S
INDNTNS
Y
V
N
S
GKAR
LH
G
V
E
F
A
GTL
P
L
WSE
D
VTLSL
N
Y
TW
T
-------
-R
SEQ
RD
GDN
K
G
A
----
P
LS
Y
T
PE
H
M
V
NA
K
L
N
W
QIT
E
EVASWLGA
R
YR
GK
-T
P
RFT
Q
NY
SSLS
AV
QKKVY
D
EK
G
EYLKA
W
T
V
V
DA
GLS
WK
M
T
D
---
A
L
T
L
NAA
V
N
NL
LN
K
D
Y
SDVS
L
YSA
G
K
---
STLY
AG
DYFQT
G
S
S
T
---
T
G
Y
VI
P
E
RNY
W
MS
L
N
YQ
F
fig|562.373.peg.200
Escherichia coli 1125A
MIVSA
SGYEKKL
T
NA
AA
S
VSVI
SQ
EE
LQ
S
S
-
Q-YH
DL
A
E
A
LR
S
-
V
E
GV
D
V
--E
S
GT
G
KT
G
-
G
L
E
ISIRGM
P
ASY
TL
------
ILIDG
-
-
------
VRQG
GS
S
D
V
T
PN
G
FSAM
N
T
GFM
PP
L
AA
IERIEV
I
RGP
M
S
T
LYG
S
D
A
M
GGVVNIIT
R
K
N
A
--------------
DK
W
LS
S
VN
A
GL
N
LQ
E
SN
K
W
---
G
----
NS
S
QF
NF
WSS
GPL
V
D
D
SVSL
Q
VR
G
STQ
Q
RQ
G
-
-
-------
SSVTSLSDTAA
T
R
I
PYPT
E
S-Q
N
Y
N
L
G
A
RL
--
D
WK
A
S
E
Q
D
V
L
WF
D
MDT
T
RQ
-----
---
R
YD
N
R
D
G
Q
LG
SL
TGG
-----------------
Y
D
R
T
L
R
Y
E
R
NKISAGYDHTFTF
G
-
TWKSYLN
W
NE
T
E
---------
N
KGRELVRSV
L
K
R
---
DKW
GL
A
G
QPR
-------
-
----
ELKE
S
NLILN
S
L
L
LT
P
L
G--ESH
L
V
T
V
G
G
E
F
QSS
S
MK
D
-------
-
------
-
--
-
G
VVLASTGETFRQ
K
SW
S
V
---
-
--
FAE
DEWH
LTD
A
L
A
L
T
AG
S
RY
--------
E
H
------------
HEQF
G
G
----------
H
F
SP
RAY
L
VWD
V
A
D
A
W
T
LK
G
G
VT
T
GYKAP
R
M
G
Q
------
L
HKGIS
G
VS-
--
GQ
G
KTN
L
-----
L
GN
P
DLKPE
E
S
V
S
Y
E
A
G
VYYDNPA
GL
N
A
N
VT
G
F
M
TD
FS
NKIV
S
-------
Y
S
INDNTNS
Y
V
N
S
GKAR
LH
G
V
E
F
A
GTL
P
L
WSE
D
VTLSL
N
Y
TW
T
-------
-R
SEQ
RD
GDN
K
G
A
----
P
LS
Y
T
PE
H
M
V
NA
K
L
N
W
QIT
E
EVASWLGA
R
YR
GK
-T
P
RFT
Q
NY
SSLS
AV
QKKVY
D
EK
G
EYLKA
W
T
V
V
DA
GLS
WK
M
T
D
---
A
L
T
L
NAA
V
N
NL
LN
K
D
Y
SDVS
L
YSA
G
K
---
STLY
AG
DYFQT
G
S
S
T
---
T
G
Y
VI
P
E
RNY
W
MS
L
N
YQ
F
fig|562.372.peg.195
Escherichia coli 1212A
MIVSA
SGYEKKL
T
NA
AA
S
VSVI
SQ
EE
LQ
S
S
-
Q-YH
DL
A
E
A
LR
S
-
V
E
GV
D
V
--E
S
GT
G
KT
G
-
G
L
E
ISIRGM
P
ASY
TL
------
ILIDG
-
-
------
VRQG
GS
S
D
V
T
PN
G
FSAM
N
T
GFM
PP
L
AA
IERIEV
I
RGP
M
S
T
LYG
S
D
A
M
GGVVNIIT
R
K
N
A
--------------
DK
W
LS
S
VN
A
GL
N
LQ
E
SN
K
W
---
G
----
NS
S
QF
NF
WSS
GPL
V
D
D
SVSL
Q
VR
G
STQ
Q
RQ
G
-
-
-------
SSVTSLSDTAA
T
R
I
PYPT
E
S-Q
N
Y
N
L
G
A
RL
--
D
WK
A
S
E
Q
D
V
L
WF
D
MDT
T
RQ
-----
---
R
YD
N
R
D
G
Q
LG
SL
TGG
-----------------
Y
D
R
T
L
R
Y
E
R
NKISAGYDHTFTF
G
-
TWKSYLN
W
NE
T
E
---------
N
KGRELVRSV
L
K
R
---
DKW
GL
A
G
QPR
-------
-
----
ELKE
S
NLILN
S
L
L
LT
P
L
G--ESH
L
V
T
V
G
G
E
F
QSS
S
MK
D
-------
-
------
-
--
-
G
VVLASTGETFRQ
K
SW
S
V
---
-
--
FAE
DEWH
LTD
A
L
A
L
T
AG
S
RY
--------
E
H
------------
HEQF
G
G
----------
H
F
SP
RAY
L
VWD
V
A
D
A
W
T
LK
G
G
VT
T
GYKAP
R
M
G
Q
------
L
HKGIS
G
VS-
--
GQ
G
KTN
L
-----
L
GN
P
DLKPE
E
S
V
S
Y
E
A
G
VYYDNPA
GL
N
A
N
VT
G
F
M
TD
FS
NKIV
S
-------
Y
S
INDNTNS
Y
V
N
S
GKAR
LH
G
V
E
F
A
GTL
P
L
WSE
D
VTLSL
N
Y
TW
T
-------
-R
SEQ
RD
GDN
K
G
A
----
P
LS
Y
T
PE
H
M
V
NA
K
L
N
W
QIT
E
EVASWLGA
R
YR
GK
-T
P
RFT
Q
NY
SSLS
AV
QKKVY
D
EK
G
EYLKA
W
T
V
V
DA
GLS
WK
M
T
D
---
A
L
T
L
NAA
V
N
NL
LN
K
D
Y
SDVS
L
YSA
G
K
---
STLY
AG
DYFQT
G
S
S
T
---
T
G
Y
VI
P
E
RNY
W
MS
L
N
YQ
F
fig|562.374.peg.631
Escherichia coli 536A
MIVSA
SGYEKKL
T
NA
AA
S
VSVI
SQ
EE
LQ
S
S
-
Q-YH
DL
A
E
A
LR
S
-
V
E
GV
D
V
--E
S
GT
G
KT
G
-
G
L
E
ISIRGM
P
ASY
TL
------
ILIDG
-
-
------
VRQG
GS
S
D
V
T
PN
G
FSAM
N
T
GFM
PP
L
AA
IERIEV
I
RGP
M
S
T
LYG
S
D
A
M
GGVVNIIT
R
K
N
A
--------------
DK
W
LS
S
VN
A
GL
N
LQ
E
SN
K
W
---
G
----
NS
S
QF
NF
WSS
GPL
V
D
D
SVSL
Q
VR
G
STQ
Q
RQ
G
-
-
-------
SSVTSLSDTAA
T
R
I
PYPT
E
S-Q
N
Y
N
L
G
A
RL
--
D
WK
A
S
E
Q
D
V
L
WF
D
MDT
T
RQ
-----
---
R
YD
N
R
D
G
Q
LG
SL
TGG
-----------------
Y
D
R
T
L
R
Y
E
R
NKISAGYDHTFTF
G
-
TWKSYLN
W
NE
T
E
---------
N
KGRELVRSV
L
K
R
---
DKW
GL
A
G
QPR
-------
-
----
ELKE
S
NLILN
S
L
L
LT
P
L
G--ESH
L
V
T
V
G
G
E
F
QSS
S
MK
D
-------
-
------
-
--
-
G
VVLASTGETFRQ
K
SW
S
V
---
-
--
FAE
DEWH
LTD
A
L
A
L
T
AG
S
RY
--------
E
H
------------
HEQF
G
G
----------
H
F
SP
RAY
L
VWD
V
A
D
A
W
T
LK
G
G
VT
T
GYKAP
R
M
G
Q
------
L
HKGIS
G
VS-
--
GQ
G
KTN
L
-----
L
GN
P
DLKPE
E
S
V
S
Y
E
A
G
VYYDNPA
GL
N
A
N
VT
G
F
M
TD
FS
NKIV
S
-------
Y
S
INDNTNS
Y
V
N
S
GKAR
LH
G
V
E
F
A
GTL
P
L
WSE
D
VTLSL
N
Y
TW
T
-------
-R
SEQ
RD
GDN
K
G
A
----
P
LS
Y
T
PE
H
M
V
NA
K
L
N
W
QIT
E
EVASWLGA
R
YR
GK
-T
P
RFT
Q
NY
SSLS
AV
QKKVY
D
EK
G
EYLKA
W
T
V
V
DA
GLS
WK
M
T
D
---
A
L
T
L
NAA
V
N
NL
LN
K
D
Y
SDVS
L
YSA
G
K
---
STLY
AG
DYFQT
G
S
S
T
---
T
G
Y
VI
P
E
RNY
W
MS
L
N
YQ
F
fig|585055.6.peg.4690
Escherichia coli 55989
MIVSA
SGYEKKL
T
NA
AA
S
VSVI
SQ
EE
LQ
S
S
-
Q-YH
DL
A
E
A
LR
S
-
V
E
GV
D
V
--E
S
GT
G
KT
G
-
G
L
E
ISIRGM
P
ASY
TL
------
ILIDG
-
-
------
VRQG
GS
S
D
V
T
PN
G
FSAM
N
T
GFM
PP
L
AA
IERIEV
I
RGP
M
S
T
LYG
S
D
A
M
GGVVNIIT
R
K
N
A
--------------
DK
W
LS
S
VN
A
GL
N
LQ
E
SN
K
W
---
G
----
NS
S
QF
NF
WSS
GPL
V
D
D
SVSL
Q
VR
G
STQ
Q
RQ
G
-
-
-------
SSVTSLSDTAA
T
R
I
PYPT
E
S-Q
N
Y
N
L
G
A
RL
--
D
WK
A
S
E
Q
D
V
L
WF
D
MDT
T
RQ
-----
---
R
YD
N
R
D
G
Q
LG
SL
TGG
-----------------
Y
D
R
T
L
R
Y
E
R
NKISAGYDHTFTF
G
-
TWKSYLN
W
NE
T
E
---------
N
KGRELVRSV
L
K
R
---
DKW
GL
A
G
QPR
-------
-
----
ELKE
S
NLILN
S
L
L
LT
P
L
G--ESH
L
V
T
V
G
G
E
F
QSS
S
MK
D
-------
-
------
-
--
-
G
VVLASTGETFRQ
K
SW
S
V
---
-
--
FAE
DEWH
LTD
A
L
A
L
T
AG
S
RY
--------
E
H
------------
HEQF
G
G
----------
H
F
SP
RAY
L
VWD
V
A
D
A
W
T
LK
G
G
VT
T
GYKAP
R
M
G
Q
------
L
HKGIS
G
VS-
--
GQ
G
KTN
L
-----
L
GN
P
DLKPE
E
S
V
S
Y
E
A
G
VYYDNPA
GL
N
A
N
VT
G
F
M
TD
FS
NKIV
S
-------
Y
S
INDNTNS
Y
V
N
S
GKAR
LH
G
V
E
F
A
GTL
P
L
WSE
D
VTLSL
N
Y
TW
T
-------
-R
SEQ
RD
GDN
K
G
A
----
P
LS
Y
T
PE
H
M
V
NA
K
L
N
W
QIT
E
EVASWLGA
R
YR
GK
-T
P
RFT
Q
NY
SSLS
AV
QKKVY
D
EK
G
EYLKA
W
T
V
V
DA
GLS
WK
M
T
D
---
A
L
T
L
NAA
V
N
NL
LN
K
D
Y
SDVS
L
YSA
G
K
---
STLY
AG
DYFQT
G
S
S
T
---
T
G
Y
VI
P
E
RNY
W
MS
L
N
YQ
F
fig|585055.8.peg.4695
Escherichia coli 55989
MIVSA
SGYEKKL
T
NA
AA
S
VSVI
SQ
EE
LQ
S
S
-
Q-YH
DL
A
E
A
LR
S
-
V
E
GV
D
V
--E
S
GT
G
KT
G
-
G
L
E
ISIRGM
P
ASY
TL
------
ILIDG
-
-
------
VRQG
GS
S
D
V
T
PN
G
FSAM
N
T
GFM
PP
L
AA
IERIEV
I
RGP
M
S
T
LYG
S
D
A
M
GGVVNIIT
R
K
N
A
--------------
DK
W
LS
S
VN
A
GL
N
LQ
E
SN
K
W
---
G
----
NS
S
QF
NF
WSS
GPL
V
D
D
SVSL
Q
VR
G
STQ
Q
RQ
G
-
-
-------
SSVTSLSDTAA
T
R
I
PYPT
E
S-Q
N
Y
N
L
G
A
RL
--
D
WK
A
S
E
Q
D
V
L
WF
D
MDT
T
RQ
-----
---
R
YD
N
R
D
G
Q
LG
SL
TGG
-----------------
Y
D
R
T
L
R
Y
E
R
NKISAGYDHTFTF
G
-
TWKSYLN
W
NE
T
E
---------
N
KGRELVRSV
L
K
R
---
DKW
GL
A
G
QPR
-------
-
----
ELKE
S
NLILN
S
L
L
LT
P
L
G--ESH
L
V
T
V
G
G
E
F
QSS
S
MK
D
-------
-
------
-
--
-
G
VVLASTGETFRQ
K
SW
S
V
---
-
--
FAE
DEWH
LTD
A
L
A
L
T
AG
S
RY
--------
E
H
------------
HEQF
G
G
----------
H
F
SP
RAY
L
VWD
V
A
D
A
W
T
LK
G
G
VT
T
GYKAP
R
M
G
Q
------
L
HKGIS
G
VS-
--
GQ
G
KTN
L
-----
L
GN
P
DLKPE
E
S
V
S
Y
E
A
G
VYYDNPA
GL
N
A
N
VT
G
F
M
TD
FS
NKIV
S
-------
Y
S
INDNTNS
Y
V
N
S
GKAR
LH
G
V
E
F
A
GTL
P
L
WSE
D
VTLSL
N
Y
TW
T
-------
-R
SEQ
RD
GDN
K
G
A
----
P
LS
Y
T
PE
H
M
V
NA
K
L
N
W
QIT
E
EVASWLGA
R
YR
GK
-T
P
RFT
Q
NY
SSLS
AV
QKKVY
D
EK
G
EYLKA
W
T
V
V
DA
GLS
WK
M
T
D
---
A
L
T
L
NAA
V
N
NL
LN
K
D
Y
SDVS
L
YSA
G
K
---
STLY
AG
DYFQT
G
S
S
T
---
T
G
Y
VI
P
E
RNY
W
MS
L
N
YQ
F
fig|340186.5.peg.4090
Escherichia coli E110019
MIVSA
SGYEKKL
T
NA
AA
S
VSVI
SQ
EE
LQ
S
S
-
Q-YH
DL
A
E
A
LR
S
-
V
E
GV
D
V
--E
S
GT
G
KT
G
-
G
L
E
ISIRGM
P
ASY
TL
------
ILIDG
-
-
------
VRQG
GS
S
D
V
T
PN
G
FSAM
N
T
GFM
PP
L
AA
IERIEV
I
RGP
M
S
T
LYG
S
D
A
M
GGVVNIIT
R
K
N
A
--------------
DK
W
LS
S
VN
A
GL
N
LQ
E
SN
K
W
---
G
----
NS
S
QF
NF
WSS
GPL
V
D
D
SVSL
Q
VR
G
STQ
Q
RQ
G
-
-
-------
SSVTSLSDTAA
T
R
I
PYPT
E
S-Q
N
Y
N
L
G
A
RL
--
D
WK
A
S
E
Q
D
V
L
WF
D
MDT
T
RQ
-----
---
R
YD
N
R
D
G
Q
LG
SL
TGG
-----------------
Y
D
R
T
L
R
Y
E
R
NKISAGYDHTFTF
G
-
TWKSYLN
W
NE
T
E
---------
N
KGRELVRSV
L
K
R
---
DKW
GL
A
G
QPR
-------
-
----
ELKE
S
NLILN
S
L
L
LT
P
L
G--ESH
L
V
T
V
G
G
E
F
QSS
S
MK
D
-------
-
------
-
--
-
G
VVLASTGETFRQ
K
SW
S
V
---
-
--
FAE
DEWH
LTD
A
L
A
L
T
AG
S
RY
--------
E
H
------------
HEQF
G
G
----------
H
F
SP
RAY
L
VWD
V
A
D
A
W
T
LK
G
G
VT
T
GYKAP
R
M
G
Q
------
L
HKGIS
G
VS-
--
GQ
G
KTN
L
-----
L
GN
P
DLKPE
E
S
V
S
Y
E
A
G
VYYDNPA
GL
N
A
N
VT
G
F
M
TD
FS
NKIV
S
-------
Y
S
INDNTNS
Y
V
N
S
GKAR
LH
G
V
E
F
A
GTL
P
L
WSE
D
VTLSL
N
Y
TW
T
-------
-R
SEQ
RD
GDN
K
G
A
----
P
LS
Y
T
PE
H
M
V
NA
K
L
N
W
QIT
E
EVASWLGA
R
YR
GK
-T
P
RFT
Q
NY
SSLS
AV
QKKVY
D
EK
G
EYLKA
W
T
V
V
DA
GLS
WK
M
T
D
---
A
L
T
L
NAA
V
N
NL
LN
K
D
Y
SDVS
L
YSA
G
K
---
STLY
AG
DYFQT
G
S
S
T
---
T
G
Y
VI
P
E
RNY
W
MS
L
N
YQ
F
fig|585397.7.peg.4879
Escherichia coli ED1a
MIVSA
SGYEKKL
T
NA
AA
S
VSVI
SQ
EE
LQ
S
S
-
Q-YH
DL
A
E
A
LR
S
-
V
E
GV
D
V
--E
S
GT
G
KT
G
-
G
L
E
ISIRGM
P
ASY
TL
------
ILIDG
-
-
------
VRQG
GS
S
D
V
T
PN
G
FSAM
N
T
GFM
PP
L
AA
IERIEV
I
RGP
M
S
T
LYG
S
D
A
M
GGVVNIIT
R
K
N
A
--------------
DK
W
LS
S
VN
A
GL
N
LQ
E
SN
K
W
---
G
----
NS
S
QF
NF
WSS
GPL
V
D
D
SVSL
Q
VR
G
STQ
Q
RQ
G
-
-
-------
SSVTSLSDTAA
T
R
I
PYPT
E
S-Q
N
Y
N
L
G
A
RL
--
D
WK
A
S
E
Q
D
V
L
WF
D
MDT
T
RQ
-----
---
R
YD
N
R
D
G
Q
LG
SL
TGG
-----------------
Y
D
R
T
L
R
Y
E
R
NKISAGYDHTFTF
G
-
TWKSYLN
W
NE
T
E
---------
N
KGRELVRSV
L
K
R
---
DKW
GL
A
G
QPR
-------
-
----
ELKE
S
NLILN
S
L
L
LT
P
L
G--ESH
L
V
T
V
G
G
E
F
QSS
S
MK
D
-------
-
------
-
--
-
G
VVLASTGETFRQ
K
SW
S
V
---
-
--
FAE
DEWH
LTD
A
L
A
L
T
AG
S
RY
--------
E
H
------------
HEQF
G
G
----------
H
F
SP
RAY
L
VWD
V
A
D
A
W
T
LK
G
G
VT
T
GYKAP
R
M
G
Q
------
L
HKGIS
G
VS-
--
GQ
G
KTN
L
-----
L
GN
P
DLKPE
E
S
V
S
Y
E
A
G
VYYDNPA
GL
N
A
N
VT
G
F
M
TD
FS
NKIV
S
-------
Y
S
INDNTNS
Y
V
N
S
GKAR
LH
G
V
E
F
A
GTL
P
L
WSE
D
VTLSL
N
Y
TW
T
-------
-R
SEQ
RD
GDN
K
G
A
----
P
LS
Y
T
PE
H
M
V
NA
K
L
N
W
QIT
E
EVASWLGA
R
YR
GK
-T
P
RFT
Q
NY
SSLS
AV
QKKVY
D
EK
G
EYLKA
W
T
V
V
DA
GLS
WK
M
T
D
---
A
L
T
L
NAA
V
N
NL
LN
K
D
Y
SDVS
L
YSA
G
K
---
STLY
AG
DYFQT
G
S
S
T
---
T
G
Y
VI
P
E
RNY
W
MS
L
N
YQ
F
fig|585397.9.peg.4879
Escherichia coli ED1a
MIVSA
SGYEKKL
T
NA
AA
S
VSVI
SQ
EE
LQ
S
S
-
Q-YH
DL
A
E
A
LR
S
-
V
E
GV
D
V
--E
S
GT
G
KT
G
-
G
L
E
ISIRGM
P
ASY
TL
------
ILIDG
-
-
------
VRQG
GS
S
D
V
T
PN
G
FSAM
N
T
GFM
PP
L
AA
IERIEV
I
RGP
M
S
T
LYG
S
D
A
M
GGVVNIIT
R
K
N
A
--------------
DK
W
LS
S
VN
A
GL
N
LQ
E
SN
K
W
---
G
----
NS
S
QF
NF
WSS
GPL
V
D
D
SVSL
Q
VR
G
STQ
Q
RQ
G
-
-
-------
SSVTSLSDTAA
T
R
I
PYPT
E
S-Q
N
Y
N
L
G
A
RL
--
D
WK
A
S
E
Q
D
V
L
WF
D
MDT
T
RQ
-----
---
R
YD
N
R
D
G
Q
LG
SL
TGG
-----------------
Y
D
R
T
L
R
Y
E
R
NKISAGYDHTFTF
G
-
TWKSYLN
W
NE
T
E
---------
N
KGRELVRSV
L
K
R
---
DKW
GL
A
G
QPR
-------
-
----
ELKE
S
NLILN
S
L
L
LT
P
L
G--ESH
L
V
T
V
G
G
E
F
QSS
S
MK
D
-------
-
------
-
--
-
G
VVLASTGETFRQ
K
SW
S
V
---
-
--
FAE
DEWH
LTD
A
L
A
L
T
AG
S
RY
--------
E
H
------------
HEQF
G
G
----------
H
F
SP
RAY
L
VWD
V
A
D
A
W
T
LK
G
G
VT
T
GYKAP
R
M
G
Q
------
L
HKGIS
G
VS-
--
GQ
G
KTN
L
-----
L
GN
P
DLKPE
E
S
V
S
Y
E
A
G
VYYDNPA
GL
N
A
N
VT
G
F
M
TD
FS
NKIV
S
-------
Y
S
INDNTNS
Y
V
N
S
GKAR
LH
G
V
E
F
A
GTL
P
L
WSE
D
VTLSL
N
Y
TW
T
-------
-R
SEQ
RD
GDN
K
G
A
----
P
LS
Y
T
PE
H
M
V
NA
K
L
N
W
QIT
E
EVASWLGA
R
YR
GK
-T
P
RFT
Q
NY
SSLS
AV
QKKVY
D
EK
G
EYLKA
W
T
V
V
DA
GLS
WK
M
T
D
---
A
L
T
L
NAA
V
N
NL
LN
K
D
Y
SDVS
L
YSA
G
K
---
STLY
AG
DYFQT
G
S
S
T
---
T
G
Y
VI
P
E
RNY
W
MS
L
N
YQ
F
fig|585396.4.peg.1314
Escherichia coli O111:H- str. 11128
MIVSA
SGYEKKL
T
NA
AA
S
VSVI
SQ
EE
LQ
S
S
-
Q-YH
DL
A
E
A
LR
S
-
V
E
GV
D
V
--E
S
GT
G
KT
G
-
G
L
E
ISIRGM
P
ASY
TL
------
ILIDG
-
-
------
VRQG
GS
S
D
V
T
PN
G
FSAM
N
T
GFM
PP
L
AA
IERIEV
I
RGP
M
S
T
LYG
S
D
A
M
GGVVNIIT
R
K
N
A
--------------
DK
W
LS
S
VN
A
GL
N
LQ
E
SN
K
W
---
G
----
NS
S
QF
NF
WSS
GPL
V
D
D
SVSL
Q
VR
G
STQ
Q
RQ
G
-
-
-------
SSVTSLSDTAA
T
R
I
PYPT
E
S-Q
N
Y
N
L
G
A
RL
--
D
WK
A
S
E
Q
D
V
L
WF
D
MDT
T
RQ
-----
---
R
YD
N
R
D
G
Q
LG
SL
TGG
-----------------
Y
D
R
T
L
R
Y
E
R
NKISAGYDHTFTF
G
-
TWKSYLN
W
NE
T
E
---------
N
KGRELVRSV
L
K
R
---
DKW
GL
A
G
QPR
-------
-
----
ELKE
S
NLILN
S
L
L
LT
P
L
G--ESH
L
V
T
V
G
G
E
F
QSS
S
MK
D
-------
-
------
-
--
-
G
VVLASTGETFRQ
K
SW
S
V
---
-
--
FAE
DEWH
LTD
A
L
A
L
T
AG
S
RY
--------
E
H
------------
HEQF
G
G
----------
H
F
SP
RAY
L
VWD
V
A
D
A
W
T
LK
G
G
VT
T
GYKAP
R
M
G
Q
------
L
HKGIS
G
VS-
--
GQ
G
KTN
L
-----
L
GN
P
DLKPE
E
S
V
S
Y
E
A
G
VYYDNPA
GL
N
A
N
VT
G
F
M
TD
FS
NKIV
S
-------
Y
S
INDNTNS
Y
V
N
S
GKAR
LH
G
V
E
F
A
GTL
P
L
WSE
D
VTLSL
N
Y
TW
T
-------
-R
SEQ
RD
GDN
K
G
A
----
P
LS
Y
T
PE
H
M
V
NA
K
L
N
W
QIT
E
EVASWLGA
R
YR
GK
-T
P
RFT
Q
NY
SSLS
AV
QKKVY
D
EK
G
EYLKA
W
T
V
V
DA
GLS
WK
M
T
D
---
A
L
T
L
NAA
V
N
NL
LN
K
D
Y
SDVS
L
YSA
G
K
---
STLY
AG
DYFQT
G
S
S
T
---
T
G
Y
VI
P
E
RNY
W
MS
L
N
YQ
F
fig|155864.8.peg.1047
Escherichia coli O157:H7 EDL933
MIVSA
SGYEKKL
T
NA
AA
S
VSVI
SQ
EE
LQ
S
S
-
Q-YH
DL
A
E
A
LR
S
-
V
E
GV
D
V
--E
S
GT
G
KT
G
-
G
L
E
ISIRGM
P
ASY
TL
------
ILIDG
-
-
------
VRQG
GS
S
D
V
T
PN
G
FSAM
N
T
GFM
PP
L
AA
IERIEV
I
RGP
M
S
T
LYG
S
D
A
M
GGVVNIIT
R
K
N
A
--------------
DK
W
LS
S
VN
A
GL
N
LQ
E
SN
K
W
---
G
----
NS
S
QF
NF
WSS
GPL
V
D
D
SVSL
Q
VR
G
STQ
Q
RQ
G
-
-
-------
SSVTSLSDTAA
T
R
I
PYPT
E
S-Q
N
Y
N
L
G
A
RL
--
D
WK
A
S
E
Q
D
V
L
WF
D
MDT
T
RQ
-----
---
R
YD
N
R
D
G
Q
LG
SL
TGG
-----------------
Y
D
R
T
L
R
Y
E
R
NKISAGYDHTFTF
G
-
TWKSYLN
W
NE
T
E
---------
N
KGRELVRSV
L
K
R
---
DKW
GL
A
G
QPR
-------
-
----
ELKE
S
NLILN
S
L
L
LT
P
L
G--ESH
L
V
T
V
G
G
E
F
QSS
S
MK
D
-------
-
------
-
--
-
G
VVLASTGETFRQ
K
SW
S
V
---
-
--
FAE
DEWH
LTD
A
L
A
L
T
AG
S
RY
--------
E
H
------------
HEQF
G
G
----------
H
F
SP
RAY
L
VWD
V
A
D
A
W
T
LK
G
G
VT
T
GYKAP
R
M
G
Q
------
L
HKGIS
G
VS-
--
GQ
G
KTN
L
-----
L
GN
P
DLKPE
E
S
V
S
Y
E
A
G
VYYDNPA
GL
N
A
N
VT
G
F
M
TD
FS
NKIV
S
-------
Y
S
INDNTNS
Y
V
N
S
GKAR
LH
G
V
E
F
A
GTL
P
L
WSE
D
VTLSL
N
Y
TW
T
-------
-R
SEQ
RD
GDN
K
G
A
----
P
LS
Y
T
PE
H
M
V
NA
K
L
N
W
QIT
E
EVASWLGA
R
YR
GK
-T
P
RFT
Q
NY
SSLS
AV
QKKVY
D
EK
G
EYLKA
W
T
V
V
DA
GLS
WK
M
T
D
---
A
L
T
L
NAA
V
N
NL
LN
K
D
Y
SDVS
L
YSA
G
K
---
STLY
AG
DYFQT
G
S
S
T
---
T
G
Y
VI
P
E
RNY
W
MS
L
N
YQ
F
fig|155864.8.peg.5552
Escherichia coli O157:H7 EDL933
MIVSA
SGYEKKL
T
NA
AA
S
VSVI
SQ
EE
LQ
S
S
-
Q-YH
DL
A
E
A
LR
S
-
V
E
GV
D
V
--E
S
GT
G
KT
G
-
G
L
E
ISIRGM
P
ASY
TL
------
ILIDG
-
-
------
VRQG
GS
S
D
V
T
PN
G
FSAM
N
T
GFM
PP
L
AA
IERIEV
I
RGP
M
S
T
LYG
S
D
A
M
GGVVNIIT
R
K
N
A
--------------
DK
W
LS
S
VN
A
GL
N
LQ
E
SN
K
W
---
G
----
NS
S
QF
NF
WSS
GPL
V
D
D
SVSL
Q
VR
G
STQ
Q
RQ
G
-
-
-------
SSVTSLSDTAA
T
R
I
PYPT
E
S-Q
N
Y
N
L
G
A
RL
--
D
WK
A
S
E
Q
D
V
L
WF
D
MDT
T
RQ
-----
---
R
YD
N
R
D
G
Q
LG
SL
TGG
-----------------
Y
D
R
T
L
R
Y
E
R
NKISAGYDHTFTF
G
-
TWKSYLN
W
NE
T
E
---------
N
KGRELVRSV
L
K
R
---
DKW
GL
A
G
QPR
-------
-
----
ELKE
S
NLILN
S
L
L
LT
P
L
G--ESH
L
V
T
V
G
G
E
F
QSS
S
MK
D
-------
-
------
-
--
-
G
VVLASTGETFRQ
K
SW
S
V
---
-
--
FAE
DEWH
LTD
A
L
A
L
T
AG
S
RY
--------
E
H
------------
HEQF
G
G
----------
H
F
SP
RAY
L
VWD
V
A
D
A
W
T
LK
G
G
VT
T
GYKAP
R
M
G
Q
------
L
HKGIS
G
VS-
--
GQ
G
KTN
L
-----
L
GN
P
DLKPE
E
S
V
S
Y
E
A
G
VYYDNPA
GL
N
A
N
VT
G
F
M
TD
FS
NKIV
S
-------
Y
S
INDNTNS
Y
V
N
S
GKAR
LH
G
V
E
F
A
GTL
P
L
WSE
D
VTLSL
N
Y
TW
T
-------
-R
SEQ
RD
GDN
K
G
A
----
P
LS
Y
T
PE
H
M
V
NA
K
L
N
W
QIT
E
EVASWLGA
R
YR
GK
-T
P
RFT
Q
NY
SSLS
AV
QKKVY
D
EK
G
EYLKA
W
T
V
V
DA
GLS
WK
M
T
D
---
A
L
T
L
NAA
V
N
NL
LN
K
D
Y
SDVS
L
YSA
G
K
---
STLY
AG
DYFQT
G
S
S
T
---
T
G
Y
VI
P
E
RNY
W
MS
L
N
YQ
F
fig|444454.5.peg.5854
Escherichia coli O157:H7 str. EC4024
MIVSA
SGYEKKL
T
NA
AA
S
VSVI
SQ
EE
LQ
S
S
-
Q-YH
DL
A
E
A
LR
S
-
V
E
GV
D
V
--E
S
GT
G
KT
G
-
G
L
E
ISIRGM
P
ASY
TL
------
ILIDG
-
-
------
VRQG
GS
S
D
V
T
PN
G
FSAM
N
T
GFM
PP
L
AA
IERIEV
I
RGP
M
S
T
LYG
S
D
A
M
GGVVNIIT
R
K
N
A
--------------
DK
W
LS
S
VN
A
GL
N
LQ
E
SN
K
W
---
G
----
NS
S
QF
NF
WSS
GPL
V
D
D
SVSL
Q
VR
G
STQ
Q
RQ
G
-
-
-------
SSVTSLSDTAA
T
R
I
PYPT
E
S-Q
N
Y
N
L
G
A
RL
--
D
WK
A
S
E
Q
D
V
L
WF
D
MDT
T
RQ
-----
---
R
YD
N
R
D
G
Q
LG
SL
TGG
-----------------
Y
D
R
T
L
R
Y
E
R
NKISAGYDHTFTF
G
-
TWKSYLN
W
NE
T
E
---------
N
KGRELVRSV
L
K
R
---
DKW
GL
A
G
QPR
-------
-
----
ELKE
S
NLILN
S
L
L
LT
P
L
G--ESH
L
V
T
V
G
G
E
F
QSS
S
MK
D
-------
-
------
-
--
-
G
VVLASTGETFRQ
K
SW
S
V
---
-
--
FAE
DEWH
LTD
A
L
A
L
T
AG
S
RY
--------
E
H
------------
HEQF
G
G
----------
H
F
SP
RAY
L
VWD
V
A
D
A
W
T
LK
G
G
VT
T
GYKAP
R
M
G
Q
------
L
HKGIS
G
VS-
--
GQ
G
KTN
L
-----
L
GN
P
DLKPE
E
S
V
S
Y
E
A
G
VYYDNPA
GL
N
A
N
VT
G
F
M
TD
FS
NKIV
S
-------
Y
S
INDNTNS
Y
V
N
S
GKAR
LH
G
V
E
F
A
GTL
P
L
WSE
D
VTLSL
N
Y
TW
T
-------
-R
SEQ
RD
GDN
K
G
A
----
P
LS
Y
T
PE
H
M
V
NA
K
L
N
W
QIT
E
EVASWLGA
R
YR
GK
-T
P
RFT
Q
NY
SSLS
AV
QKKVY
D
EK
G
EYLKA
W
T
V
V
DA
GLS
WK
M
T
D
---
A
L
T
L
NAA
V
N
NL
LN
K
D
Y
SDVS
L
YSA
G
K
---
STLY
AG
DYFQT
G
S
S
T
---
T
G
Y
VI
P
E
RNY
W
MS
L
N
YQ
F
fig|444449.5.peg.4705
Escherichia coli O157:H7 str. EC4042
MIVSA
SGYEKKL
T
NA
AA
S
VSVI
SQ
EE
LQ
S
S
-
Q-YH
DL
A
E
A
LR
S
-
V
E
GV
D
V
--E
S
GT
G
KT
G
-
G
L
E
ISIRGM
P
ASY
TL
------
ILIDG
-
-
------
VRQG
GS
S
D
V
T
PN
G
FSAM
N
T
GFM
PP
L
AA
IERIEV
I
RGP
M
S
T
LYG
S
D
A
M
GGVVNIIT
R
K
N
A
--------------
DK
W
LS
S
VN
A
GL
N
LQ
E
SN
K
W
---
G
----
NS
S
QF
NF
WSS
GPL
V
D
D
SVSL
Q
VR
G
STQ
Q
RQ
G
-
-
-------
SSVTSLSDTAA
T
R
I
PYPT
E
S-Q
N
Y
N
L
G
A
RL
--
D
WK
A
S
E
Q
D
V
L
WF
D
MDT
T
RQ
-----
---
R
YD
N
R
D
G
Q
LG
SL
TGG
-----------------
Y
D
R
T
L
R
Y
E
R
NKISAGYDHTFTF
G
-
TWKSYLN
W
NE
T
E
---------
N
KGRELVRSV
L
K
R
---
DKW
GL
A
G
QPR
-------
-
----
ELKE
S
NLILN
S
L
L
LT
P
L
G--ESH
L
V
T
V
G
G
E
F
QSS
S
MK
D
-------
-
------
-
--
-
G
VVLASTGETFRQ
K
SW
S
V
---
-
--
FAE
DEWH
LTD
A
L
A
L
T
AG
S
RY
--------
E
H
------------
HEQF
G
G
----------
H
F
SP
RAY
L
VWD
V
A
D
A
W
T
LK
G
G
VT
T
GYKAP
R
M
G
Q
------
L
HKGIS
G
VS-
--
GQ
G
KTN
L
-----
L
GN
P
DLKPE
E
S
V
S
Y
E
A
G
VYYDNPA
GL
N
A
N
VT
G
F
M
TD
FS
NKIV
S
-------
Y
S
INDNTNS
Y
V
N
S
GKAR
LH
G
V
E
F
A
GTL
P
L
WSE
D
VTLSL
N
Y
TW
T
-------
-R
SEQ
RD
GDN
K
G
A
----
P
LS
Y
T
PE
H
M
V
NA
K
L
N
W
QIT
E
EVASWLGA
R
YR
GK
-T
P
RFT
Q
NY
SSLS
AV
QKKVY
D
EK
G
EYLKA
W
T
V
V
DA
GLS
WK
M
T
D
---
A
L
T
L
NAA
V
N
NL
LN
K
D
Y
SDVS
L
YSA
G
K
---
STLY
AG
DYFQT
G
S
S
T
---
T
G
Y
VI
P
E
RNY
W
MS
L
N
YQ
F
fig|444448.5.peg.3974
Escherichia coli O157:H7 str. EC4045
MIVSA
SGYEKKL
T
NA
AA
S
VSVI
SQ
EE
LQ
S
S
-
Q-YH
DL
A
E
A
LR
S
-
V
E
GV
D
V
--E
S
GT
G
KT
G
-
G
L
E
ISIRGM
P
ASY
TL
------
ILIDG
-
-
------
VRQG
GS
S
D
V
T
PN
G
FSAM
N
T
GFM
PP
L
AA
IERIEV
I
RGP
M
S
T
LYG
S
D
A
M
GGVVNIIT
R
K
N
A
--------------
DK
W
LS
S
VN
A
GL
N
LQ
E
SN
K
W
---
G
----
NS
S
QF
NF
WSS
GPL
V
D
D
SVSL
Q
VR
G
STQ
Q
RQ
G
-
-
-------
SSVTSLSDTAA
T
R
I
PYPT
E
S-Q
N
Y
N
L
G
A
RL
--
D
WK
A
S
E
Q
D
V
L
WF
D
MDT
T
RQ
-----
---
R
YD
N
R
D
G
Q
LG
SL
TGG
-----------------
Y
D
R
T
L
R
Y
E
R
NKISAGYDHTFTF
G
-
TWKSYLN
W
NE
T
E
---------
N
KGRELVRSV
L
K
R
---
DKW
GL
A
G
QPR
-------
-
----
ELKE
S
NLILN
S
L
L
LT
P
L
G--ESH
L
V
T
V
G
G
E
F
QSS
S
MK
D
-------
-
------
-
--
-
G
VVLASTGETFRQ
K
SW
S
V
---
-
--
FAE
DEWH
LTD
A
L
A
L
T
AG
S
RY
--------
E
H
------------
HEQF
G
G
----------
H
F
SP
RAY
L
VWD
V
A
D
A
W
T
LK
G
G
VT
T
GYKAP
R
M
G
Q
------
L
HKGIS
G
VS-
--
GQ
G
KTN
L
-----
L
GN
P
DLKPE
E
S
V
S
Y
E
A
G
VYYDNPA
GL
N
A
N
VT
G
F
M
TD
FS
NKIV
S
-------
Y
S
INDNTNS
Y
V
N
S
GKAR
LH
G
V
E
F
A
GTL
P
L
WSE
D
VTLSL
N
Y
TW
T
-------
-R
SEQ
RD
GDN
K
G
A
----
P
LS
Y
T
PE
H
M
V
NA
K
L
N
W
QIT
E
EVASWLGA
R
YR
GK
-T
P
RFT
Q
NY
SSLS
AV
QKKVY
D
EK
G
EYLKA
W
T
V
V
DA
GLS
WK
M
T
D
---
A
L
T
L
NAA
V
N
NL
LN
K
D
Y
SDVS
L
YSA
G
K
---
STLY
AG
DYFQT
G
S
S
T
---
T
G
Y
VI
P
E
RNY
W
MS
L
N
YQ
F
fig|444453.5.peg.2591
Escherichia coli O157:H7 str. EC4076
MIVSA
SGYEKKL
T
NA
AA
S
VSVI
SQ
EE
LQ
S
S
-
Q-YH
DL
A
E
A
LR
S
-
V
E
GV
D
V
--E
S
GT
G
KT
G
-
G
L
E
ISIRGM
P
ASY
TL
------
ILIDG
-
-
------
VRQG
GS
S
D
V
T
PN
G
FSAM
N
T
GFM
PP
L
AA
IERIEV
I
RGP
M
S
T
LYG
S
D
A
M
GGVVNIIT
R
K
N
A
--------------
DK
W
LS
S
VN
A
GL
N
LQ
E
SN
K
W
---
G
----
NS
S
QF
NF
WSS
GPL
V
D
D
SVSL
Q
VR
G
STQ
Q
RQ
G
-
-
-------
SSVTSLSDTAA
T
R
I
PYPT
E
S-Q
N
Y
N
L
G
A
RL
--
D
WK
A
S
E
Q
D
V
L
WF
D
MDT
T
RQ
-----
---
R
YD
N
R
D
G
Q
LG
SL
TGG
-----------------
Y
D
R
T
L
R
Y
E
R
NKISAGYDHTFTF
G
-
TWKSYLN
W
NE
T
E
---------
N
KGRELVRSV
L
K
R
---
DKW
GL
A
G
QPR
-------
-
----
ELKE
S
NLILN
S
L
L
LT
P
L
G--ESH
L
V
T
V
G
G
E
F
QSS
S
MK
D
-------
-
------
-
--
-
G
VVLASTGETFRQ
K
SW
S
V
---
-
--
FAE
DEWH
LTD
A
L
A
L
T
AG
S
RY
--------
E
H
------------
HEQF
G
G
----------
H
F
SP
RAY
L
VWD
V
A
D
A
W
T
LK
G
G
VT
T
GYKAP
R
M
G
Q
------
L
HKGIS
G
VS-
--
GQ
G
KTN
L
-----
L
GN
P
DLKPE
E
S
V
S
Y
E
A
G
VYYDNPA
GL
N
A
N
VT
G
F
M
TD
FS
NKIV
S
-------
Y
S
INDNTNS
Y
V
N
S
GKAR
LH
G
V
E
F
A
GTL
P
L
WSE
D
VTLSL
N
Y
TW
T
-------
-R
SEQ
RD
GDN
K
G
A
----
P
LS
Y
T
PE
H
M
V
NA
K
L
N
W
QIT
E
EVASWLGA
R
YR
GK
-T
P
RFT
Q
NY
SSLS
AV
QKKVY
D
EK
G
EYLKA
W
T
V
V
DA
GLS
WK
M
T
D
---
A
L
T
L
NAA
V
N
NL
LN
K
D
Y
SDVS
L
YSA
G
K
---
STLY
AG
DYFQT
G
S
S
T
---
T
G
Y
VI
P
E
RNY
W
MS
L
N
YQ
F
fig|444452.5.peg.406
Escherichia coli O157:H7 str. EC4113
MIVSA
SGYEKKL
T
NA
AA
S
VSVI
SQ
EE
LQ
S
S
-
Q-YH
DL
A
E
A
LR
S
-
V
E
GV
D
V
--E
S
GT
G
KT
G
-
G
L
E
ISIRGM
P
ASY
TL
------
ILIDG
-
-
------
VRQG
GS
S
D
V
T
PN
G
FSAM
N
T
GFM
PP
L
AA
IERIEV
I
RGP
M
S
T
LYG
S
D
A
M
GGVVNIIT
R
K
N
A
--------------
DK
W
LS
S
VN
A
GL
N
LQ
E
SN
K
W
---
G
----
NS
S
QF
NF
WSS
GPL
V
D
D
SVSL
Q
VR
G
STQ
Q
RQ
G
-
-
-------
SSVTSLSDTAA
T
R
I
PYPT
E
S-Q
N
Y
N
L
G
A
RL
--
D
WK
A
S
E
Q
D
V
L
WF
D
MDT
T
RQ
-----
---
R
YD
N
R
D
G
Q
LG
SL
TGG
-----------------
Y
D
R
T
L
R
Y
E
R
NKISAGYDHTFTF
G
-
TWKSYLN
W
NE
T
E
---------
N
KGRELVRSV
L
K
R
---
DKW
GL
A
G
QPR
-------
-
----
ELKE
S
NLILN
S
L
L
LT
P
L
G--ESH
L
V
T
V
G
G
E
F
QSS
S
MK
D
-------
-
------
-
--
-
G
VVLASTGETFRQ
K
SW
S
V
---
-
--
FAE
DEWH
LTD
A
L
A
L
T
AG
S
RY
--------
E
H
------------
HEQF
G
G
----------
H
F
SP
RAY
L
VWD
V
A
D
A
W
T
LK
G
G
VT
T
GYKAP
R
M
G
Q
------
L
HKGIS
G
VS-
--
GQ
G
KTN
L
-----
L
GN
P
DLKPE
E
S
V
S
Y
E
A
G
VYYDNPA
GL
N
A
N
VT
G
F
M
TD
FS
NKIV
S
-------
Y
S
INDNTNS
Y
V
N
S
GKAR
LH
G
V
E
F
A
GTL
P
L
WSE
D
VTLSL
N
Y
TW
T
-------
-R
SEQ
RD
GDN
K
G
A
----
P
LS
Y
T
PE
H
M
V
NA
K
L
N
W
QIT
E
EVASWLGA
R
YR
GK
-T
P
RFT
Q
NY
SSLS
AV
QKKVY
D
EK
G
EYLKA
W
T
V
V
DA
GLS
WK
M
T
D
---
A
L
T
L
NAA
V
N
NL
LN
K
D
Y
SDVS
L
YSA
G
K
---
STLY
AG
DYFQT
G
S
S
T
---
T
G
Y
VI
P
E
RNY
W
MS
L
N
YQ
F
fig|444450.8.peg.1434
Escherichia coli O157:H7 str. EC4115
MIVSA
SGYEKKL
T
NA
AA
S
VSVI
SQ
EE
LQ
S
S
-
Q-YH
DL
A
E
A
LR
S
-
V
E
GV
D
V
--E
S
GT
G
KT
G
-
G
L
E
ISIRGM
P
ASY
TL
------
ILIDG
-
-
------
VRQG
GS
S
D
V
T
PN
G
FSAM
N
T
GFM
PP
L
AA
IERIEV
I
RGP
M
S
T
LYG
S
D
A
M
GGVVNIIT
R
K
N
A
--------------
DK
W
LS
S
VN
A
GL
N
LQ
E
SN
K
W
---
G
----
NS
S
QF
NF
WSS
GPL
V
D
D
SVSL
Q
VR
G
STQ
Q
RQ
G
-
-
-------
SSVTSLSDTAA
T
R
I
PYPT
E
S-Q
N
Y
N
L
G
A
RL
--
D
WK
A
S
E
Q
D
V
L
WF
D
MDT
T
RQ
-----
---
R
YD
N
R
D
G
Q
LG
SL
TGG
-----------------
Y
D
R
T
L
R
Y
E
R
NKISAGYDHTFTF
G
-
TWKSYLN
W
NE
T
E
---------
N
KGRELVRSV
L
K
R
---
DKW
GL
A
G
QPR
-------
-
----
ELKE
S
NLILN
S
L
L
LT
P
L
G--ESH
L
V
T
V
G
G
E
F
QSS
S
MK
D
-------
-
------
-
--
-
G
VVLASTGETFRQ
K
SW
S
V
---
-
--
FAE
DEWH
LTD
A
L
A
L
T
AG
S
RY
--------
E
H
------------
HEQF
G
G
----------
H
F
SP
RAY
L
VWD
V
A
D
A
W
T
LK
G
G
VT
T
GYKAP
R
M
G
Q
------
L
HKGIS
G
VS-
--
GQ
G
KTN
L
-----
L
GN
P
DLKPE
E
S
V
S
Y
E
A
G
VYYDNPA
GL
N
A
N
VT
G
F
M
TD
FS
NKIV
S
-------
Y
S
INDNTNS
Y
V
N
S
GKAR
LH
G
V
E
F
A
GTL
P
L
WSE
D
VTLSL
N
Y
TW
T
-------
-R
SEQ
RD
GDN
K
G
A
----
P
LS
Y
T
PE
H
M
V
NA
K
L
N
W
QIT
E
EVASWLGA
R
YR
GK
-T
P
RFT
Q
NY
SSLS
AV
QKKVY
D
EK
G
EYLKA
W
T
V
V
DA
GLS
WK
M
T
D
---
A
L
T
L
NAA
V
N
NL
LN
K
D
Y
SDVS
L
YSA
G
K
---
STLY
AG
DYFQT
G
S
S
T
---
T
G
Y
VI
P
E
RNY
W
MS
L
N
YQ
F
fig|444451.5.peg.1485
Escherichia coli O157:H7 str. EC4196
MIVSA
SGYEKKL
T
NA
AA
S
VSVI
SQ
EE
LQ
S
S
-
Q-YH
DL
A
E
A
LR
S
-
V
E
GV
D
V
--E
S
GT
G
KT
G
-
G
L
E
ISIRGM
P
ASY
TL
------
ILIDG
-
-
------
VRQG
GS
S
D
V
T
PN
G
FSAM
N
T
GFM
PP
L
AA
IERIEV
I
RGP
M
S
T
LYG
S
D
A
M
GGVVNIIT
R
K
N
A
--------------
DK
W
LS
S
VN
A
GL
N
LQ
E
SN
K
W
---
G
----
NS
S
QF
NF
WSS
GPL
V
D
D
SVSL
Q
VR
G
STQ
Q
RQ
G
-
-
-------
SSVTSLSDTAA
T
R
I
PYPT
E
S-Q
N
Y
N
L
G
A
RL
--
D
WK
A
S
E
Q
D
V
L
WF
D
MDT
T
RQ
-----
---
R
YD
N
R
D
G
Q
LG
SL
TGG
-----------------
Y
D
R
T
L
R
Y
E
R
NKISAGYDHTFTF
G
-
TWKSYLN
W
NE
T
E
---------
N
KGRELVRSV
L
K
R
---
DKW
GL
A
G
QPR
-------
-
----
ELKE
S
NLILN
S
L
L
LT
P
L
G--ESH
L
V
T
V
G
G
E
F
QSS
S
MK
D
-------
-
------
-
--
-
G
VVLASTGETFRQ
K
SW
S
V
---
-
--
FAE
DEWH
LTD
A
L
A
L
T
AG
S
RY
--------
E
H
------------
HEQF
G
G
----------
H
F
SP
RAY
L
VWD
V
A
D
A
W
T
LK
G
G
VT
T
GYKAP
R
M
G
Q
------
L
HKGIS
G
VS-
--
GQ
G
KTN
L
-----
L
GN
P
DLKPE
E
S
V
S
Y
E
A
G
VYYDNPA
GL
N
A
N
VT
G
F
M
TD
FS
NKIV
S
-------
Y
S
INDNTNS
Y
V
N
S
GKAR
LH
G
V
E
F
A
GTL
P
L
WSE
D
VTLSL
N
Y
TW
T
-------
-R
SEQ
RD
GDN
K
G
A
----
P
LS
Y
T
PE
H
M
V
NA
K
L
N
W
QIT
E
EVASWLGA
R
YR
GK
-T
P
RFT
Q
NY
SSLS
AV
QKKVY
D
EK
G
EYLKA
W
T
V
V
DA
GLS
WK
M
T
D
---
A
L
T
L
NAA
V
N
NL
LN
K
D
Y
SDVS
L
YSA
G
K
---
STLY
AG
DYFQT
G
S
S
T
---
T
G
Y
VI
P
E
RNY
W
MS
L
N
YQ
F
fig|444447.5.peg.4208
Escherichia coli O157:H7 str. EC4206
MIVSA
SGYEKKL
T
NA
AA
S
VSVI
SQ
EE
LQ
S
S
-
Q-YH
DL
A
E
A
LR
S
-
V
E
GV
D
V
--E
S
GT
G
KT
G
-
G
L
E
ISIRGM
P
ASY
TL
------
ILIDG
-
-
------
VRQG
GS
S
D
V
T
PN
G
FSAM
N
T
GFM
PP
L
AA
IERIEV
I
RGP
M
S
T
LYG
S
D
A
M
GGVVNIIT
R
K
N
A
--------------
DK
W
LS
S
VN
A
GL
N
LQ
E
SN
K
W
---
G
----
NS
S
QF
NF
WSS
GPL
V
D
D
SVSL
Q
VR
G
STQ
Q
RQ
G
-
-
-------
SSVTSLSDTAA
T
R
I
PYPT
E
S-Q
N
Y
N
L
G
A
RL
--
D
WK
A
S
E
Q
D
V
L
WF
D
MDT
T
RQ
-----
---
R
YD
N
R
D
G
Q
LG
SL
TGG
-----------------
Y
D
R
T
L
R
Y
E
R
NKISAGYDHTFTF
G
-
TWKSYLN
W
NE
T
E
---------
N
KGRELVRSV
L
K
R
---
DKW
GL
A
G
QPR
-------
-
----
ELKE
S
NLILN
S
L
L
LT
P
L
G--ESH
L
V
T
V
G
G
E
F
QSS
S
MK
D
-------
-
------
-
--
-
G
VVLASTGETFRQ
K
SW
S
V
---
-
--
FAE
DEWH
LTD
A
L
A
L
T
AG
S
RY
--------
E
H
------------
HEQF
G
G
----------
H
F
SP
RAY
L
VWD
V
A
D
A
W
T
LK
G
G
VT
T
GYKAP
R
M
G
Q
------
L
HKGIS
G
VS-
--
GQ
G
KTN
L
-----
L
GN
P
DLKPE
E
S
V
S
Y
E
A
G
VYYDNPA
GL
N
A
N
VT
G
F
M
TD
FS
NKIV
S
-------
Y
S
INDNTNS
Y
V
N
S
GKAR
LH
G
V
E
F
A
GTL
P
L
WSE
D
VTLSL
N
Y
TW
T
-------
-R
SEQ
RD
GDN
K
G
A
----
P
LS
Y
T
PE
H
M
V
NA
K
L
N
W
QIT
E
EVASWLGA
R
YR
GK
-T
P
RFT
Q
NY
SSLS
AV
QKKVY
D
EK
G
EYLKA
W
T
V
V
DA
GLS
WK
M
T
D
---
A
L
T
L
NAA
V
N
NL
LN
K
D
Y
SDVS
L
YSA
G
K
---
STLY
AG
DYFQT
G
S
S
T
---
T
G
Y
VI
P
E
RNY
W
MS
L
N
YQ
F
fig|478004.5.peg.1271
Escherichia coli O157:H7 str. EC4401
MIVSA
SGYEKKL
T
NA
AA
S
VSVI
SQ
EE
LQ
S
S
-
Q-YH
DL
A
E
A
LR
S
-
V
E
GV
D
V
--E
S
GT
G
KT
G
-
G
L
E
ISIRGM
P
ASY
TL
------
ILIDG
-
-
------
VRQG
GS
S
D
V
T
PN
G
FSAM
N
T
GFM
PP
L
AA
IERIEV
I
RGP
M
S
T
LYG
S
D
A
M
GGVVNIIT
R
K
N
A
--------------
DK
W
LS
S
VN
A
GL
N
LQ
E
SN
K
W
---
G
----
NS
S
QF
NF
WSS
GPL
V
D
D
SVSL
Q
VR
G
STQ
Q
RQ
G
-
-
-------
SSVTSLSDTAA
T
R
I
PYPT
E
S-Q
N
Y
N
L
G
A
RL
--
D
WK
A
S
E
Q
D
V
L
WF
D
MDT
T
RQ
-----
---
R
YD
N
R
D
G
Q
LG
SL
TGG
-----------------
Y
D
R
T
L
R
Y
E
R
NKISAGYDHTFTF
G
-
TWKSYLN
W
NE
T
E
---------
N
KGRELVRSV
L
K
R
---
DKW
GL
A
G
QPR
-------
-
----
ELKE
S
NLILN
S
L
L
LT
P
L
G--ESH
L
V
T
V
G
G
E
F
QSS
S
MK
D
-------
-
------
-
--
-
G
VVLASTGETFRQ
K
SW
S
V
---
-
--
FAE
DEWH
LTD
A
L
A
L
T
AG
S
RY
--------
E
H
------------
HEQF
G
G
----------
H
F
SP
RAY
L
VWD
V
A
D
A
W
T
LK
G
G
VT
T
GYKAP
R
M
G
Q
------
L
HKGIS
G
VS-
--
GQ
G
KTN
L
-----
L
GN
P
DLKPE
E
S
V
S
Y
E
A
G
VYYDNPA
GL
N
A
N
VT
G
F
M
TD
FS
NKIV
S
-------
Y
S
INDNTNS
Y
V
N
S
GKAR
LH
G
V
E
F
A
GTL
P
L
WSE
D
VTLSL
N
Y
TW
T
-------
-R
SEQ
RD
GDN
K
G
A
----
P
LS
Y
T
PE
H
M
V
NA
K
L
N
W
QIT
E
EVASWLGA
R
YR
GK
-T
P
RFT
Q
NY
SSLS
AV
QKKVY
D
EK
G
EYLKA
W
T
V
V
DA
GLS
WK
M
T
D
---
A
L
T
L
NAA
V
N
NL
LN
K
D
Y
SDVS
L
YSA
G
K
---
STLY
AG
DYFQT
G
S
S
T
---
T
G
Y
VI
P
E
RNY
W
MS
L
N
YQ
F
fig|478006.5.peg.1225
Escherichia coli O157:H7 str. EC4501
MIVSA
SGYEKKL
T
NA
AA
S
VSVI
SQ
EE
LQ
S
S
-
Q-YH
DL
A
E
A
LR
S
-
V
E
GV
D
V
--E
S
GT
G
KT
G
-
G
L
E
ISIRGM
P
ASY
TL
------
ILIDG
-
-
------
VRQG
GS
S
D
V
T
PN
G
FSAM
N
T
GFM
PP
L
AA
IERIEV
I
RGP
M
S
T
LYG
S
D
A
M
GGVVNIIT
R
K
N
A
--------------
DK
W
LS
S
VN
A
GL
N
LQ
E
SN
K
W
---
G
----
NS
S
QF
NF
WSS
GPL
V
D
D
SVSL
Q
VR
G
STQ
Q
RQ
G
-
-
-------
SSVTSLSDTAA
T
R
I
PYPT
E
S-Q
N
Y
N
L
G
A
RL
--
D
WK
A
S
E
Q
D
V
L
WF
D
MDT
T
RQ
-----
---
R
YD
N
R
D
G
Q
LG
SL
TGG
-----------------
Y
D
R
T
L
R
Y
E
R
NKISAGYDHTFTF
G
-
TWKSYLN
W
NE
T
E
---------
N
KGRELVRSV
L
K
R
---
DKW
GL
A
G
QPR
-------
-
----
ELKE
S
NLILN
S
L
L
LT
P
L
G--ESH
L
V
T
V
G
G
E
F
QSS
S
MK
D
-------
-
------
-
--
-
G
VVLASTGETFRQ
K
SW
S
V
---
-
--
FAE
DEWH
LTD
A
L
A
L
T
AG
S
RY
--------
E
H
------------
HEQF
G
G
----------
H
F
SP
RAY
L
VWD
V
A
D
A
W
T
LK
G
G
VT
T
GYKAP
R
M
G
Q
------
L
HKGIS
G
VS-
--
GQ
G
KTN
L
-----
L
GN
P
DLKPE
E
S
V
S
Y
E
A
G
VYYDNPA
GL
N
A
N
VT
G
F
M
TD
FS
NKIV
S
-------
Y
S
INDNTNS
Y
V
N
S
GKAR
LH
G
V
E
F
A
GTL
P
L
WSE
D
VTLSL
N
Y
TW
T
-------
-R
SEQ
RD
GDN
K
G
A
----
P
LS
Y
T
PE
H
M
V
NA
K
L
N
W
QIT
E
EVASWLGA
R
YR
GK
-T
P
RFT
Q
NY
SSLS
AV
QKKVY
D
EK
G
EYLKA
W
T
V
V
DA
GLS
WK
M
T
D
---
A
L
T
L
NAA
V
N
NL
LN
K
D
Y
SDVS
L
YSA
G
K
---
STLY
AG
DYFQT
G
S
S
T
---
T
G
Y
VI
P
E
RNY
W
MS
L
N
YQ
F
fig|478007.5.peg.2005
Escherichia coli O157:H7 str. EC508
MIVSA
SGYEKKL
T
NA
AA
S
VSVI
SQ
EE
LQ
S
S
-
Q-YH
DL
A
E
A
LR
S
-
V
E
GV
D
V
--E
S
GT
G
KT
G
-
G
L
E
ISIRGM
P
ASY
TL
------
ILIDG
-
-
------
VRQG
GS
S
D
V
T
PN
G
FSAM
N
T
GFM
PP
L
AA
IERIEV
I
RGP
M
S
T
LYG
S
D
A
M
GGVVNIIT
R
K
N
A
--------------
DK
W
LS
S
VN
A
GL
N
LQ
E
SN
K
W
---
G
----
NS
S
QF
NF
WSS
GPL
V
D
D
SVSL
Q
VR
G
STQ
Q
RQ
G
-
-
-------
SSVTSLSDTAA
T
R
I
PYPT
E
S-Q
N
Y
N
L
G
A
RL
--
D
WK
A
S
E
Q
D
V
L
WF
D
MDT
T
RQ
-----
---
R
YD
N
R
D
G
Q
LG
SL
TGG
-----------------
Y
D
R
T
L
R
Y
E
R
NKISAGYDHTFTF
G
-
TWKSYLN
W
NE
T
E
---------
N
KGRELVRSV
L
K
R
---
DKW
GL
A
G
QPR
-------
-
----
ELKE
S
NLILN
S
L
L
LT
P
L
G--ESH
L
V
T
V
G
G
E
F
QSS
S
MK
D
-------
-
------
-
--
-
G
VVLASTGETFRQ
K
SW
S
V
---
-
--
FAE
DEWH
LTD
A
L
A
L
T
AG
S
RY
--------
E
H
------------
HEQF
G
G
----------
H
F
SP
RAY
L
VWD
V
A
D
A
W
T
LK
G
G
VT
T
GYKAP
R
M
G
Q
------
L
HKGIS
G
VS-
--
GQ
G
KTN
L
-----
L
GN
P
DLKPE
E
S
V
S
Y
E
A
G
VYYDNPA
GL
N
A
N
VT
G
F
M
TD
FS
NKIV
S
-------
Y
S
INDNTNS
Y
V
N
S
GKAR
LH
G
V
E
F
A
GTL
P
L
WSE
D
VTLSL
N
Y
TW
T
-------
-R
SEQ
RD
GDN
K
G
A
----
P
LS
Y
T
PE
H
M
V
NA
K
L
N
W
QIT
E
EVASWLGA
R
YR
GK
-T
P
RFT
Q
NY
SSLS
AV
QKKVY
D
EK
G
EYLKA
W
T
V
V
DA
GLS
WK
M
T
D
---
A
L
T
L
NAA
V
N
NL
LN
K
D
Y
SDVS
L
YSA
G
K
---
STLY
AG
DYFQT
G
S
S
T
---
T
G
Y
VI
P
E
RNY
W
MS
L
N
YQ
F
fig|478008.5.peg.4007
Escherichia coli O157:H7 str. EC869
MIVSA
SGYEKKL
T
NA
AA
S
VSVI
SQ
EE
LQ
S
S
-
Q-YH
DL
A
E
A
LR
S
-
V
E
GV
D
V
--E
S
GT
G
KT
G
-
G
L
E
ISIRGM
P
ASY
TL
------
ILIDG
-
-
------
VRQG
GS
S
D
V
T
PN
G
FSAM
N
T
GFM
PP
L
AA
IERIEV
I
RGP
M
S
T
LYG
S
D
A
M
GGVVNIIT
R
K
N
A
--------------
DK
W
LS
S
VN
A
GL
N
LQ
E
SN
K
W
---
G
----
NS
S
QF
NF
WSS
GPL
V
D
D
SVSL
Q
VR
G
STQ
Q
RQ
G
-
-
-------
SSVTSLSDTAA
T
R
I
PYPT
E
S-Q
N
Y
N
L
G
A
RL
--
D
WK
A
S
E
Q
D
V
L
WF
D
MDT
T
RQ
-----
---
R
YD
N
R
D
G
Q
LG
SL
TGG
-----------------
Y
D
R
T
L
R
Y
E
R
NKISAGYDHTFTF
G
-
TWKSYLN
W
NE
T
E
---------
N
KGRELVRSV
L
K
R
---
DKW
GL
A
G
QPR
-------
-
----
ELKE
S
NLILN
S
L
L
LT
P
L
G--ESH
L
V
T
V
G
G
E
F
QSS
S
MK
D
-------
-
------
-
--
-
G
VVLASTGETFRQ
K
SW
S
V
---
-
--
FAE
DEWH
LTD
A
L
A
L
T
AG
S
RY
--------
E
H
------------
HEQF
G
G
----------
H
F
SP
RAY
L
VWD
V
A
D
A
W
T
LK
G
G
VT
T
GYKAP
R
M
G
Q
------
L
HKGIS
G
VS-
--
GQ
G
KTN
L
-----
L
GN
P
DLKPE
E
S
V
S
Y
E
A
G
VYYDNPA
GL
N
A
N
VT
G
F
M
TD
FS
NKIV
S
-------
Y
S
INDNTNS
Y
V
N
S
GKAR
LH
G
V
E
F
A
GTL
P
L
WSE
D
VTLSL
N
Y
TW
T
-------
-R
SEQ
RD
GDN
K
G
A
----
P
LS
Y
T
PE
H
M
V
NA
K
L
N
W
QIT
E
EVASWLGA
R
YR
GK
-T
P
RFT
Q
NY
SSLS
AV
QKKVY
D
EK
G
EYLKA
W
T
V
V
DA
GLS
WK
M
T
D
---
A
L
T
L
NAA
V
N
NL
LN
K
D
Y
SDVS
L
YSA
G
K
---
STLY
AG
DYFQT
G
S
S
T
---
T
G
Y
VI
P
E
RNY
W
MS
L
N
YQ
F
fig|637388.3.peg.4440
Escherichia coli O157:H7 str. FRIK2000
MIVSA
SGYEKKL
T
NA
AA
S
VSVI
SQ
EE
LQ
S
S
-
Q-YH
DL
A
E
A
LR
S
-
V
E
GV
D
V
--E
S
GT
G
KT
G
-
G
L
E
ISIRGM
P
ASY
TL
------
ILIDG
-
-
------
VRQG
GS
S
D
V
T
PN
G
FSAM
N
T
GFM
PP
L
AA
IERIEV
I
RGP
M
S
T
LYG
S
D
A
M
GGVVNIIT
R
K
N
A
--------------
DK
W
LS
S
VN
A
GL
N
LQ
E
SN
K
W
---
G
----
NS
S
QF
NF
WSS
GPL
V
D
D
SVSL
Q
VR
G
STQ
Q
RQ
G
-
-
-------
SSVTSLSDTAA
T
R
I
PYPT
E
S-Q
N
Y
N
L
G
A
RL
--
D
WK
A
S
E
Q
D
V
L
WF
D
MDT
T
RQ
-----
---
R
YD
N
R
D
G
Q
LG
SL
TGG
-----------------
Y
D
R
T
L
R
Y
E
R
NKISAGYDHTFTF
G
-
TWKSYLN
W
NE
T
E
---------
N
KGRELVRSV
L
K
R
---
DKW
GL
A
G
QPR
-------
-
----
ELKE
S
NLILN
S
L
L
LT
P
L
G--ESH
L
V
T
V
G
G
E
F
QSS
S
MK
D
-------
-
------
-
--
-
G
VVLASTGETFRQ
K
SW
S
V
---
-
--
FAE
DEWH
LTD
A
L
A
L
T
AG
S
RY
--------
E
H
------------
HEQF
G
G
----------
H
F
SP
RAY
L
VWD
V
A
D
A
W
T
LK
G
G
VT
T
GYKAP
R
M
G
Q
------
L
HKGIS
G
VS-
--
GQ
G
KTN
L
-----
L
GN
P
DLKPE
E
S
V
S
Y
E
A
G
VYYDNPA
GL
N
A
N
VT
G
F
M
TD
FS
NKIV
S
-------
Y
S
INDNTNS
Y
V
N
S
GKAR
LH
G
V
E
F
A
GTL
P
L
WSE
D
VTLSL
N
Y
TW
T
-------
-R
SEQ
RD
GDN
K
G
A
----
P
LS
Y
T
PE
H
M
V
NA
K
L
N
W
QIT
E
EVASWLGA
R
YR
GK
-T
P
RFT
Q
NY
SSLS
AV
QKKVY
D
EK
G
EYLKA
W
T
V
V
DA
GLS
WK
M
T
D
---
A
L
T
L
NAA
V
N
NL
LN
K
D
Y
SDVS
L
YSA
G
K
---
STLY
AG
DYFQT
G
S
S
T
---
T
G
Y
VI
P
E
RNY
W
MS
L
N
YQ
F
fig|570506.3.peg.554
Escherichia coli O157:H7 str. FRIK966
MIVSA
SGYEKKL
T
NA
AA
S
VSVI
SQ
EE
LQ
S
S
-
Q-YH
DL
A
E
A
LR
S
-
V
E
GV
D
V
--E
S
GT
G
KT
G
-
G
L
E
ISIRGM
P
ASY
TL
------
ILIDG
-
-
------
VRQG
GS
S
D
V
T
PN
G
FSAM
N
T
GFM
PP
L
AA
IERIEV
I
RGP
M
S
T
LYG
S
D
A
M
GGVVNIIT
R
K
N
A
--------------
DK
W
LS
S
VN
A
GL
N
LQ
E
SN
K
W
---
G
----
NS
S
QF
NF
WSS
GPL
V
D
D
SVSL
Q
VR
G
STQ
Q
RQ
G
-
-
-------
SSVTSLSDTAA
T
R
I
PYPT
E
S-Q
N
Y
N
L
G
A
RL
--
D
WK
A
S
E
Q
D
V
L
WF
D
MDT
T
RQ
-----
---
R
YD
N
R
D
G
Q
LG
SL
TGG
-----------------
Y
D
R
T
L
R
Y
E
R
NKISAGYDHTFTF
G
-
TWKSYLN
W
NE
T
E
---------
N
KGRELVRSV
L
K
R
---
DKW
GL
A
G
QPR
-------
-
----
ELKE
S
NLILN
S
L
L
LT
P
L
G--ESH
L
V
T
V
G
G
E
F
QSS
S
MK
D
-------
-
------
-
--
-
G
VVLASTGETFRQ
K
SW
S
V
---
-
--
FAE
DEWH
LTD
A
L
A
L
T
AG
S
RY
--------
E
H
------------
HEQF
G
G
----------
H
F
SP
RAY
L
VWD
V
A
D
A
W
T
LK
G
G
VT
T
GYKAP
R
M
G
Q
------
L
HKGIS
G
VS-
--
GQ
G
KTN
L
-----
L
GN
P
DLKPE
E
S
V
S
Y
E
A
G
VYYDNPA
GL
N
A
N
VT
G
F
M
TD
FS
NKIV
S
-------
Y
S
INDNTNS
Y
V
N
S
GKAR
LH
G
V
E
F
A
GTL
P
L
WSE
D
VTLSL
N
Y
TW
T
-------
-R
SEQ
RD
GDN
K
G
A
----
P
LS
Y
T
PE
H
M
V
NA
K
L
N
W
QIT
E
EVASWLGA
R
YR
GK
-T
P
RFT
Q
NY
SSLS
AV
QKKVY
D
EK
G
EYLKA
W
T
V
V
DA
GLS
WK
M
T
D
---
A
L
T
L
NAA
V
N
NL
LN
K
D
Y
SDVS
L
YSA
G
K
---
STLY
AG
DYFQT
G
S
S
T
---
T
G
Y
VI
P
E
RNY
W
MS
L
N
YQ
F
fig|386585.9.peg.1463
Escherichia coli O157:H7 str. Sakai
MIVSA
SGYEKKL
T
NA
AA
S
VSVI
SQ
EE
LQ
S
S
-
Q-YH
DL
A
E
A
LR
S
-
V
E
GV
D
V
--E
S
GT
G
KT
G
-
G
L
E
ISIRGM
P
ASY
TL
------
ILIDG
-
-
------
VRQG
GS
S
D
V
T
PN
G
FSAM
N
T
GFM
PP
L
AA
IERIEV
I
RGP
M
S
T
LYG
S
D
A
M
GGVVNIIT
R
K
N
A
--------------
DK
W
LS
S
VN
A
GL
N
LQ
E
SN
K
W
---
G
----
NS
S
QF
NF
WSS
GPL
V
D
D
SVSL
Q
VR
G
STQ
Q
RQ
G
-
-
-------
SSVTSLSDTAA
T
R
I
PYPT
E
S-Q
N
Y
N
L
G
A
RL
--
D
WK
A
S
E
Q
D
V
L
WF
D
MDT
T
RQ
-----
---
R
YD
N
R
D
G
Q
LG
SL
TGG
-----------------
Y
D
R
T
L
R
Y
E
R
NKISAGYDHTFTF
G
-
TWKSYLN
W
NE
T
E
---------
N
KGRELVRSV
L
K
R
---
DKW
GL
A
G
QPR
-------
-
----
ELKE
S
NLILN
S
L
L
LT
P
L
G--ESH
L
V
T
V
G
G
E
F
QSS
S
MK
D
-------
-
------
-
--
-
G
VVLASTGETFRQ
K
SW
S
V
---
-
--
FAE
DEWH
LTD
A
L
A
L
T
AG
S
RY
--------
E
H
------------
HEQF
G
G
----------
H
F
SP
RAY
L
VWD
V
A
D
A
W
T
LK
G
G
VT
T
GYKAP
R
M
G
Q
------
L
HKGIS
G
VS-
--
GQ
G
KTN
L
-----
L
GN
P
DLKPE
E
S
V
S
Y
E
A
G
VYYDNPA
GL
N
A
N
VT
G
F
M
TD
FS
NKIV
S
-------
Y
S
INDNTNS
Y
V
N
S
GKAR
LH
G
V
E
F
A
GTL
P
L
WSE
D
VTLSL
N
Y
TW
T
-------
-R
SEQ
RD
GDN
K
G
A
----
P
LS
Y
T
PE
H
M
V
NA
K
L
N
W
QIT
E
EVASWLGA
R
YR
GK
-T
P
RFT
Q
NY
SSLS
AV
QKKVY
D
EK
G
EYLKA
W
T
V
V
DA
GLS
WK
M
T
D
---
A
L
T
L
NAA
V
N
NL
LN
K
D
Y
SDVS
L
YSA
G
K
---
STLY
AG
DYFQT
G
S
S
T
---
T
G
Y
VI
P
E
RNY
W
MS
L
N
YQ
F
fig|544404.4.peg.1297
Escherichia coli O157:H7 str. TW14359
MIVSA
SGYEKKL
T
NA
AA
S
VSVI
SQ
EE
LQ
S
S
-
Q-YH
DL
A
E
A
LR
S
-
V
E
GV
D
V
--E
S
GT
G
KT
G
-
G
L
E
ISIRGM
P
ASY
TL
------
ILIDG
-
-
------
VRQG
GS
S
D
V
T
PN
G
FSAM
N
T
GFM
PP
L
AA
IERIEV
I
RGP
M
S
T
LYG
S
D
A
M
GGVVNIIT
R
K
N
A
--------------
DK
W
LS
S
VN
A
GL
N
LQ
E
SN
K
W
---
G
----
NS
S
QF
NF
WSS
GPL
V
D
D
SVSL
Q
VR
G
STQ
Q
RQ
G
-
-
-------
SSVTSLSDTAA
T
R
I
PYPT
E
S-Q
N
Y
N
L
G
A
RL
--
D
WK
A
S
E
Q
D
V
L
WF
D
MDT
T
RQ
-----
---
R
YD
N
R
D
G
Q
LG
SL
TGG
-----------------
Y
D
R
T
L
R
Y
E
R
NKISAGYDHTFTF
G
-
TWKSYLN
W
NE
T
E
---------
N
KGRELVRSV
L
K
R
---
DKW
GL
A
G
QPR
-------
-
----
ELKE
S
NLILN
S
L
L
LT
P
L
G--ESH
L
V
T
V
G
G
E
F
QSS
S
MK
D
-------
-
------
-
--
-
G
VVLASTGETFRQ
K
SW
S
V
---
-
--
FAE
DEWH
LTD
A
L
A
L
T
AG
S
RY
--------
E
H
------------
HEQF
G
G
----------
H
F
SP
RAY
L
VWD
V
A
D
A
W
T
LK
G
G
VT
T
GYKAP
R
M
G
Q
------
L
HKGIS
G
VS-
--
GQ
G
KTN
L
-----
L
GN
P
DLKPE
E
S
V
S
Y
E
A
G
VYYDNPA
GL
N
A
N
VT
G
F
M
TD
FS
NKIV
S
-------
Y
S
INDNTNS
Y
V
N
S
GKAR
LH
G
V
E
F
A
GTL
P
L
WSE
D
VTLSL
N
Y
TW
T
-------
-R
SEQ
RD
GDN
K
G
A
----
P
LS
Y
T
PE
H
M
V
NA
K
L
N
W
QIT
E
EVASWLGA
R
YR
GK
-T
P
RFT
Q
NY
SSLS
AV
QKKVY
D
EK
G
EYLKA
W
T
V
V
DA
GLS
WK
M
T
D
---
A
L
T
L
NAA
V
N
NL
LN
K
D
Y
SDVS
L
YSA
G
K
---
STLY
AG
DYFQT
G
S
S
T
---
T
G
Y
VI
P
E
RNY
W
MS
L
N
YQ
F
fig|502346.5.peg.2924
Escherichia coli O157:H7 str. TW14588
MIVSA
SGYEKKL
T
NA
AA
S
VSVI
SQ
EE
LQ
S
S
-
Q-YH
DL
A
E
A
LR
S
-
V
E
GV
D
V
--E
S
GT
G
KT
G
-
G
L
E
ISIRGM
P
ASY
TL
------
ILIDG
-
-
------
VRQG
GS
S
D
V
T
PN
G
FSAM
N
T
GFM
PP
L
AA
IERIEV
I
RGP
M
S
T
LYG
S
D
A
M
GGVVNIIT
R
K
N
A
--------------
DK
W
LS
S
VN
A
GL
N
LQ
E
SN
K
W
---
G
----
NS
S
QF
NF
WSS
GPL
V
D
D
SVSL
Q
VR
G
STQ
Q
RQ
G
-
-
-------
SSVTSLSDTAA
T
R
I
PYPT
E
S-Q
N
Y
N
L
G
A
RL
--
D
WK
A
S
E
Q
D
V
L
WF
D
MDT
T
RQ
-----
---
R
YD
N
R
D
G
Q
LG
SL
TGG
-----------------
Y
D
R
T
L
R
Y
E
R
NKISAGYDHTFTF
G
-
TWKSYLN
W
NE
T
E
---------
N
KGRELVRSV
L
K
R
---
DKW
GL
A
G
QPR
-------
-
----
ELKE
S
NLILN
S
L
L
LT
P
L
G--ESH
L
V
T
V
G
G
E
F
QSS
S
MK
D
-------
-
------
-
--
-
G
VVLASTGETFRQ
K
SW
S
V
---
-
--
FAE
DEWH
LTD
A
L
A
L
T
AG
S
RY
--------
E
H
------------
HEQF
G
G
----------
H
F
SP
RAY
L
VWD
V
A
D
A
W
T
LK
G
G
VT
T
GYKAP
R
M
G
Q
------
L
HKGIS
G
VS-
--
GQ
G
KTN
L
-----
L
GN
P
DLKPE
E
S
V
S
Y
E
A
G
VYYDNPA
GL
N
A
N
VT
G
F
M
TD
FS
NKIV
S
-------
Y
S
INDNTNS
Y
V
N
S
GKAR
LH
G
V
E
F
A
GTL
P
L
WSE
D
VTLSL
N
Y
TW
T
-------
-R
SEQ
RD
GDN
K
G
A
----
P
LS
Y
T
PE
H
M
V
NA
K
L
N
W
QIT
E
EVASWLGA
R
YR
GK
-T
P
RFT
Q
NY
SSLS
AV
QKKVY
D
EK
G
EYLKA
W
T
V
V
DA
GLS
WK
M
T
D
---
A
L
T
L
NAA
V
N
NL
LN
K
D
Y
SDVS
L
YSA
G
K
---
STLY
AG
DYFQT
G
S
S
T
---
T
G
Y
VI
P
E
RNY
W
MS
L
N
YQ
F
fig|573235.3.peg.1340
Escherichia coli O26:H11 str. 11368
MIVSA
SGYEKKL
T
NA
AA
S
VSVI
SQ
EE
LQ
S
S
-
Q-YH
DL
A
E
A
LR
S
-
V
E
GV
D
V
--E
S
GT
G
KT
G
-
G
L
E
ISIRGM
P
ASY
TL
------
ILIDG
-
-
------
VRQG
GS
S
D
V
T
PN
G
FSAM
N
T
GFM
PP
L
AA
IERIEV
I
RGP
M
S
T
LYG
S
D
A
M
GGVVNIIT
R
K
N
A
--------------
DK
W
LS
S
VN
A
GL
N
LQ
E
SN
K
W
---
G
----
NS
S
QF
NF
WSS
GPL
V
D
D
SVSL
Q
VR
G
STQ
Q
RQ
G
-
-
-------
SSVTSLSDTAA
T
R
I
PYPT
E
S-Q
N
Y
N
L
G
A
RL
--
D
WK
A
S
E
Q
D
V
L
WF
D
MDT
T
RQ
-----
---
R
YD
N
R
D
G
Q
LG
SL
TGG
-----------------
Y
D
R
T
L
R
Y
E
R
NKISAGYDHTFTF
G
-
TWKSYLN
W
NE
T
E
---------
N
KGRELVRSV
L
K
R
---
DKW
GL
A
G
QPR
-------
-
----
ELKE
S
NLILN
S
L
L
LT
P
L
G--ESH
L
V
T
V
G
G
E
F
QSS
S
MK
D
-------
-
------
-
--
-
G
VVLASTGETFRQ
K
SW
S
V
---
-
--
FAE
DEWH
LTD
A
L
A
L
T
AG
S
RY
--------
E
H
------------
HEQF
G
G
----------
H
F
SP
RAY
L
VWD
V
A
D
A
W
T
LK
G
G
VT
T
GYKAP
R
M
G
Q
------
L
HKGIS
G
VS-
--
GQ
G
KTN
L
-----
L
GN
P
DLKPE
E
S
V
S
Y
E
A
G
VYYDNPA
GL
N
A
N
VT
G
F
M
TD
FS
NKIV
S
-------
Y
S
INDNTNS
Y
V
N
S
GKAR
LH
G
V
E
F
A
GTL
P
L
WSE
D
VTLSL
N
Y
TW
T
-------
-R
SEQ
RD
GDN
K
G
A
----
P
LS
Y
T
PE
H
M
V
NA
K
L
N
W
QIT
E
EVASWLGA
R
YR
GK
-T
P
RFT
Q
NY
SSLS
AV
QKKVY
D
EK
G
EYLKA
W
T
V
V
DA
GLS
WK
M
T
D
---
A
L
T
L
NAA
V
N
NL
LN
K
D
Y
SDVS
L
YSA
G
K
---
STLY
AG
DYFQT
G
S
S
T
---
T
G
Y
VI
P
E
RNY
W
MS
L
N
YQ
F
fig|749548.3.peg.2312
Escherichia coli MS 196-1
MIVSA
SGYEKKL
T
NA
AA
S
VSVI
SQ
EE
LQ
S
S
-
Q-YH
DL
A
E
A
LR
S
-
V
E
GV
D
V
--E
S
GT
G
KT
G
-
G
L
E
ISIRGM
P
ASY
TL
------
ILIDG
-
-
------
VRQG
GS
S
D
V
T
PN
G
FSAM
N
T
GFM
PP
L
AA
IERIEV
I
RGP
M
S
T
LYG
S
D
A
M
GGVVNIIT
R
K
N
A
--------------
DK
W
LS
S
VN
A
GL
N
LQ
E
SN
K
W
---
G
----
NS
S
QF
NF
WSS
GPL
V
D
D
SVSL
Q
VR
G
STQ
Q
RQ
G
-
-
-------
SSVTSLSDTAA
T
R
I
PYPT
E
S-Q
N
Y
N
L
G
A
RL
--
D
WK
A
S
E
Q
D
V
L
WF
D
MDT
T
RQ
-----
---
R
YD
N
R
D
G
Q
LG
SL
TGG
-----------------
Y
D
R
T
L
R
Y
E
R
NKISAGYDHTFTF
G
-
TWKSYLN
W
NE
T
E
---------
N
KGRELVRSV
L
K
R
---
DKW
GL
A
G
QPR
-------
-
----
ELKE
S
NLILN
S
L
L
LT
P
L
G--ESH
L
V
T
V
G
G
E
F
QSS
S
MK
D
-------
-
------
-
--
-
G
VVLASTGETFRQ
K
SW
S
V
---
-
--
FAE
DEWH
LTD
A
L
A
L
T
V
G
S
RY
--------
E
H
------------
HEQF
G
G
----------
H
F
SP
RAY
L
VWD
V
A
D
A
W
T
LK
G
G
VT
T
GYKAP
R
M
G
Q
------
L
HKGIS
G
VS-
--
GQ
G
KTN
L
-----
L
GN
P
DLKPE
E
S
V
S
Y
E
A
G
VYYDNPA
GL
N
A
N
VT
G
F
M
TD
FS
NKIV
S
-------
Y
S
INDNTNS
Y
V
N
S
GKAR
LH
G
V
E
F
A
GTL
P
L
WSE
D
VTLSL
N
Y
TW
T
-------
-R
SEQ
RD
GDN
K
G
A
----
P
LS
Y
T
PE
H
M
V
NA
K
L
N
W
QIT
E
EVASWLGA
R
YR
GK
-T
P
RFT
Q
NY
SSLS
AV
QKKVY
D
EK
G
EYLKA
W
T
V
V
DA
GLS
WK
M
T
D
---
A
L
T
L
NAA
V
N
NL
LN
K
D
Y
SDVS
L
YSA
G
K
---
STLY
AG
DYFQT
G
S
S
T
---
T
G
Y
VI
P
E
RNY
W
MS
L
N
YQ
F
fig|199310.4.peg.3398
Escherichia coli CFT073
MIVSA
SGYEKKL
T
NA
AA
S
VSVI
SQ
EE
LQ
S
S
-
Q-YH
DL
A
E
A
LR
S
-
V
E
GV
D
V
--E
S
GT
G
KT
G
-
G
L
E
ISIRGM
P
ASY
TL
------
ILIDG
-
-
------
VRQG
GS
S
D
V
T
PN
G
FSAM
N
T
GFM
PP
L
AA
IERIEV
I
RGP
M
S
T
LYG
S
D
A
M
GGVVNIIT
R
K
N
A
--------------
DK
W
LS
S
VN
A
GL
N
LQ
E
SN
K
W
---
G
----
NS
S
QF
NF
WSS
GPL
V
D
D
SVSL
Q
VR
G
STQ
Q
RQ
G
-
-
-------
SSVTSLSDTAA
T
R
I
PYPT
E
S-Q
N
Y
N
L
G
A
RL
--
D
WK
A
S
E
Q
D
V
L
WF
D
MDT
T
RQ
-----
---
R
YD
N
R
D
G
Q
LG
SL
TGG
-----------------
Y
D
R
T
L
R
Y
E
R
NKISAGYDHTFTF
G
-
TWKSYLN
W
NE
T
E
---------
N
KGRELVRSV
L
K
R
---
DKW
GL
A
G
QPR
-------
-
----
ELKE
S
NLILN
S
L
L
LT
P
L
G--ESH
L
V
T
V
G
G
E
F
QSS
S
MK
D
-------
-
------
-
--
-
G
VVLASTGETFRQ
K
SW
S
V
---
-
--
FAE
DEWH
LTD
A
L
A
L
T
AG
S
RY
--------
E
H
------------
HEQF
G
G
----------
H
F
SP
RAY
L
VWD
V
A
D
A
W
T
LK
G
G
VT
T
GYKAP
R
M
G
Q
------
L
HKGIS
G
VS-
--
GQ
G
KTN
L
-----
L
GN
P
N
LKPE
E
S
V
S
Y
E
A
G
VYYDNPA
GL
N
A
N
VT
G
F
M
TD
FS
NKIV
S
-------
Y
S
INDNTNS
Y
V
N
S
GKAR
LH
G
V
E
F
A
GTL
P
L
WSE
D
VTLSL
N
Y
TW
T
-------
-R
SEQ
RD
GDN
K
G
A
----
P
LS
Y
T
PE
H
M
V
NA
K
L
N
W
QIT
E
EVASWLGA
R
YR
GK
-T
P
RFT
Q
NY
SSLS
AV
QKKVY
D
EK
G
EYLKA
W
T
V
V
DA
GLS
WK
M
T
D
---
A
L
T
L
NAA
V
N
NL
LN
K
D
Y
SDVS
L
YSA
G
K
---
STLY
AG
DYFQT
G
S
S
T
---
T
G
Y
VI
P
E
RNY
W
MS
L
N
YQ
F
fig|656379.3.peg.4395
Escherichia coli FVEC1302
MIVSA
SGYEKKL
T
NA
AA
S
VSVI
SQ
EE
LQ
S
S
-
Q-YH
DL
A
E
A
LR
S
-
V
E
GV
D
V
--E
S
GT
G
KT
G
-
G
L
E
ISIRGM
P
ASY
TL
------
ILIDG
-
-
------
VRQG
GS
S
D
V
T
PN
G
FSAM
N
T
GFM
PP
L
AA
IERIEV
I
RGP
M
S
T
LYG
S
D
A
M
GGVVNIIT
R
K
N
A
--------------
DK
W
LS
S
VN
A
GL
N
LQ
E
SN
K
W
---
G
----
NS
S
QF
NF
WSS
GPL
V
D
D
SVSL
Q
VR
G
STQ
Q
RQ
G
-
-
-------
SSVTSLSDTAA
T
R
I
PYPT
E
S-Q
N
Y
N
L
G
A
RL
--
D
WK
A
S
E
Q
D
V
L
WF
D
MDT
T
RQ
-----
---
R
YD
N
R
D
G
Q
LG
SL
TGG
-----------------
Y
D
R
T
L
R
Y
E
R
NKISAGYDHTFTF
G
-
TWKSYLN
W
NE
T
E
---------
N
KGRELVRSV
L
K
R
---
DKW
GL
A
G
QPR
-------
-
----
ELKE
S
NLILN
S
L
L
LT
P
L
G--ESH
L
V
T
V
G
G
E
F
QSS
S
MK
D
-------
-
------
-
--
-
G
VVLASTGETFRQ
K
SW
S
V
---
-
--
FAE
DEWH
LTD
A
L
A
L
T
AG
S
RY
--------
E
H
------------
HEQF
G
G
----------
H
F
SP
RAY
L
VWD
V
A
D
A
W
T
LK
G
G
VT
T
GYKAP
R
M
G
Q
------
L
HKGIS
G
VS-
--
GQ
G
KTN
L
-----
L
GN
P
N
LKPE
E
S
V
S
Y
E
A
G
VYYDNPA
GL
N
A
N
VT
G
F
M
TD
FS
NKIV
S
-------
Y
S
INDNTNS
Y
V
N
S
GKAR
LH
G
V
E
F
A
GTL
P
L
WSE
D
VTLSL
N
Y
TW
T
-------
-R
SEQ
RD
GDN
K
G
A
----
P
LS
Y
T
PE
H
M
V
NA
K
L
N
W
QIT
E
EVASWLGA
R
YR
GK
-T
P
RFT
Q
NY
SSLS
AV
QKKVY
D
EK
G
EYLKA
W
T
V
V
DA
GLS
WK
M
T
D
---
A
L
T
L
NAA
V
N
NL
LN
K
D
Y
SDVS
L
YSA
G
K
---
STLY
AG
DYFQT
G
S
S
T
---
T
G
Y
VI
P
E
RNY
W
MS
L
N
YQ
F
fig|656380.3.peg.4308
Escherichia coli FVEC1412
MIVSA
SGYEKKL
T
NA
AA
S
VSVI
SQ
EE
LQ
S
S
-
Q-YH
DL
A
E
A
LR
S
-
V
E
GV
D
V
--E
S
GT
G
KT
G
-
G
L
E
ISIRGM
P
ASY
TL
------
ILIDG
-
-
------
VRQG
GS
S
D
V
T
PN
G
FSAM
N
T
GFM
PP
L
AA
IERIEV
I
RGP
M
S
T
LYG
S
D
A
M
GGVVNIIT
R
K
N
A
--------------
DK
W
LS
S
VN
A
GL
N
LQ
E
SN
K
W
---
G
----
NS
S
QF
NF
WSS
GPL
V
D
D
SVSL
Q
VR
G
STQ
Q
RQ
G
-
-
-------
SSVTSLSDTAA
T
R
I
PYPT
E
S-Q
N
Y
N
L
G
A
RL
--
D
WK
A
S
E
Q
D
V
L
WF
D
MDT
T
RQ
-----
---
R
YD
N
R
D
G
Q
LG
SL
TGG
-----------------
Y
D
R
T
L
R
Y
E
R
NKISAGYDHTFTF
G
-
TWKSYLN
W
NE
T
E
---------
N
KGRELVRSV
L
K
R
---
DKW
GL
A
G
QPR
-------
-
----
ELKE
S
NLILN
S
L
L
LT
P
L
G--ESH
L
V
T
V
G
G
E
F
QSS
S
MK
D
-------
-
------
-
--
-
G
VVLASTGETFRQ
K
SW
S
V
---
-
--
FAE
DEWH
LTD
A
L
A
L
T
AG
S
RY
--------
E
H
------------
HEQF
G
G
----------
H
F
SP
RAY
L
VWD
V
A
D
A
W
T
LK
G
G
VT
T
GYKAP
R
M
G
Q
------
L
HKGIS
G
VS-
--
GQ
G
KTN
L
-----
L
GN
P
N
LKPE
E
S
V
S
Y
E
A
G
VYYDNPA
GL
N
A
N
VT
G
F
M
TD
FS
NKIV
S
-------
Y
S
INDNTNS
Y
V
N
S
GKAR
LH
G
V
E
F
A
GTL
P
L
WSE
D
VTLSL
N
Y
TW
T
-------
-R
SEQ
RD
GDN
K
G
A
----
P
LS
Y
T
PE
H
M
V
NA
K
L
N
W
QIT
E
EVASWLGA
R
YR
GK
-T
P
RFT
Q
NY
SSLS
AV
QKKVY
D
EK
G
EYLKA
W
T
V
V
DA
GLS
WK
M
T
D
---
A
L
T
L
NAA
V
N
NL
LN
K
D
Y
SDVS
L
YSA
G
K
---
STLY
AG
DYFQT
G
S
S
T
---
T
G
Y
VI
P
E
RNY
W
MS
L
N
YQ
F
fig|749549.3.peg.2887
Escherichia coli MS 198-1
MIVSA
SGYEKKL
T
NA
AA
S
VSVI
SQ
EE
LQ
S
S
-
Q-YH
DL
A
E
A
LR
S
-
V
E
GV
D
V
--E
S
GT
G
KT
G
-
G
L
E
ISIRGM
P
ASY
TL
------
ILIDG
-
-
------
VRQG
GS
S
D
V
T
PN
G
FSAM
N
T
GFM
PP
L
AA
IERIEV
I
RGP
M
S
T
LYG
S
D
A
M
GGVVNIIT
R
K
N
A
--------------
DK
W
LS
S
VN
A
GL
N
LQ
E
SN
K
W
---
G
----
NS
S
QF
NF
WSS
GPL
V
D
D
SVSL
Q
VR
G
STQ
Q
RQ
G
-
-
-------
SSVTSLSDTAA
T
R
I
PYPT
E
S-Q
N
Y
N
L
G
A
RL
--
D
WK
A
S
E
Q
D
V
L
WF
D
MDT
T
RQ
-----
---
R
YD
N
R
D
G
Q
LG
SL
TGG
-----------------
Y
D
R
T
L
R
Y
E
R
NKISAGYDHTFTF
G
-
TWKSYLN
W
NE
T
E
---------
N
KGRELVRSV
L
K
R
---
DKW
GL
A
G
QPR
-------
-
----
ELKE
S
NLILN
S
L
L
LT
P
L
G--ESH
L
V
T
V
G
G
E
F
QSS
S
MK
D
-------
-
------
-
--
-
G
VVLASTGETFRQ
K
SW
S
V
---
-
--
FAE
DEWH
LTD
A
L
A
L
T
AG
S
RY
--------
E
H
------------
HEQF
G
G
----------
H
F
SP
RAY
L
VWD
V
A
D
A
W
T
LK
G
G
VT
T
GYKAP
R
M
G
Q
------
L
HKGIS
G
VS-
--
GQ
G
KTN
L
-----
L
GN
P
N
LKPE
E
S
V
S
Y
E
A
G
VYYDNPA
GL
N
A
N
VT
G
F
M
TD
FS
NKIV
S
-------
Y
S
INDNTNS
Y
V
N
S
GKAR
LH
G
V
E
F
A
GTL
P
L
WSE
D
VTLSL
N
Y
TW
T
-------
-R
SEQ
RD
GDN
K
G
A
----
P
LS
Y
T
PE
H
M
V
NA
K
L
N
W
QIT
E
EVASWLGA
R
YR
GK
-T
P
RFT
Q
NY
SSLS
AV
QKKVY
D
EK
G
EYLKA
W
T
V
V
DA
GLS
WK
M
T
D
---
A
L
T
L
NAA
V
N
NL
LN
K
D
Y
SDVS
L
YSA
G
K
---
STLY
AG
DYFQT
G
S
S
T
---
T
G
Y
VI
P
E
RNY
W
MS
L
N
YQ
F
fig|749531.3.peg.1494
Escherichia coli MS 69-1
MIVSA
SGYEKKL
T
NA
AA
S
VSVI
SQ
EE
LQ
S
S
-
Q-YH
DL
A
E
A
LR
S
-
V
E
GV
D
V
--E
S
GT
G
KT
G
-
G
L
E
ISIRGM
P
ASY
TL
------
ILIDG
-
-
------
VRQG
GS
S
D
V
T
PN
G
FSAM
N
T
GFM
PP
L
AA
IERIEV
I
RGP
M
S
T
LYG
S
D
A
M
GGVVNIIT
R
K
N
A
--------------
DK
W
LS
S
VN
A
GL
N
LQ
E
SN
K
W
---
G
----
NS
S
QF
NF
WSS
GPL
V
D
D
SVSL
Q
VR
G
STQ
Q
RQ
G
-
-
-------
SSVTSLSDTAA
T
R
I
PYPT
E
S-Q
N
Y
N
L
G
A
RL
--
D
WK
A
S
E
Q
D
V
L
WF
D
MDT
T
RQ
-----
---
R
YD
N
R
D
G
Q
LG
SL
TGG
-----------------
Y
D
R
T
L
R
Y
E
R
NKISAGYDHTFTF
G
-
TWKSYLN
W
NE
T
E
---------
N
KGRELVRSV
L
K
R
---
DKW
GL
A
G
QPR
-------
-
----
ELKE
S
NLILN
S
L
L
LT
P
L
G--ESH
L
V
T
V
G
G
E
F
QSS
S
MK
D
-------
-
------
-
--
-
G
VVLASTGETFRQ
K
SW
S
V
---
-
--
FAE
DEWH
LTD
A
L
A
L
T
AG
S
RY
--------
E
H
------------
HEQF
G
G
----------
H
F
SP
RAY
L
VWD
V
A
D
A
W
T
LK
G
G
VT
T
GYKAP
R
M
G
Q
------
L
HKGIS
G
VS-
--
GQ
G
KTN
L
-----
L
GN
P
N
LKPE
E
S
V
S
Y
E
A
G
VYYDNPA
GL
N
A
N
VT
G
F
M
TD
FS
NKIV
S
-------
Y
S
INDNTNS
Y
V
N
S
GKAR
LH
G
V
E
F
A
GTL
P
L
WSE
D
VTLSL
N
Y
TW
T
-------
-R
SEQ
RD
GDN
K
G
A
----
P
LS
Y
T
PE
H
M
V
NA
K
L
N
W
QIT
E
EVASWLGA
R
YR
GK
-T
P
RFT
Q
NY
SSLS
AV
QKKVY
D
EK
G
EYLKA
W
T
V
V
DA
GLS
WK
M
T
D
---
A
L
T
L
NAA
V
N
NL
LN
K
D
Y
SDVS
L
YSA
G
K
---
STLY
AG
DYFQT
G
S
S
T
---
T
G
Y
VI
P
E
RNY
W
MS
L
N
YQ
F
fig|585056.7.peg.3535
Escherichia coli UMN026
MIVSA
SGYEKKL
T
NA
AA
S
VSVI
SQ
EE
LQ
S
S
-
Q-YH
DL
A
E
A
LR
S
-
V
E
GV
D
V
--E
S
GT
G
KT
G
-
G
L
E
ISIRGM
P
ASY
TL
------
ILIDG
-
-
------
VRQG
GS
S
D
V
T
PN
G
FSAM
N
T
GFM
PP
L
AA
IERIEV
I
RGP
M
S
T
LYG
S
D
A
M
GGVVNIIT
R
K
N
A
--------------
DK
W
LS
S
VN
A
GL
N
LQ
E
SN
K
W
---
G
----
NS
S
QF
NF
WSS
GPL
V
D
D
SVSL
Q
VR
G
STQ
Q
RQ
G
-
-
-------
SSVTSLSDTAA
T
R
I
PYPT
E
S-Q
N
Y
N
L
G
A
RL
--
D
WK
A
S
E
Q
D
V
L
WF
D
MDT
T
RQ
-----
---
R
YD
N
R
D
G
Q
LG
SL
TGG
-----------------
Y
D
R
T
L
R
Y
E
R
NKISAGYDHTFTF
G
-
TWKSYLN
W
NE
T
E
---------
N
KGRELVRSV
L
K
R
---
DKW
GL
A
G
QPR
-------
-
----
ELKE
S
NLILN
S
L
L
LT
P
L
G--ESH
L
V
T
V
G
G
E
F
QSS
S
MK
D
-------
-
------
-
--
-
G
VVLASTGETFRQ
K
SW
S
V
---
-
--
FAE
DEWH
LTD
A
L
A
L
T
AG
S
RY
--------
E
H
------------
HEQF
G
G
----------
H
F
SP
RAY
L
VWD
V
A
D
A
W
T
LK
G
G
VT
T
GYKAP
R
M
G
Q
------
L
HKGIS
G
VS-
--
GQ
G
KTN
L
-----
L
GN
P
N
LKPE
E
S
V
S
Y
E
A
G
VYYDNPA
GL
N
A
N
VT
G
F
M
TD
FS
NKIV
S
-------
Y
S
INDNTNS
Y
V
N
S
GKAR
LH
G
V
E
F
A
GTL
P
L
WSE
D
VTLSL
N
Y
TW
T
-------
-R
SEQ
RD
GDN
K
G
A
----
P
LS
Y
T
PE
H
M
V
NA
K
L
N
W
QIT
E
EVASWLGA
R
YR
GK
-T
P
RFT
Q
NY
SSLS
AV
QKKVY
D
EK
G
EYLKA
W
T
V
V
DA
GLS
WK
M
T
D
---
A
L
T
L
NAA
V
N
NL
LN
K
D
Y
SDVS
L
YSA
G
K
---
STLY
AG
DYFQT
G
S
S
T
---
T
G
Y
VI
P
E
RNY
W
MS
L
N
YQ
F
fig|525281.3.peg.3287
Escherichia coli 83972
MIVSA
SGYEKKL
T
NA
AA
S
VSVI
SQ
EE
LQ
S
S
-
Q-YH
DL
A
E
A
LR
S
-
V
E
GV
D
V
--E
S
GT
G
KT
G
-
G
L
E
ISIRGM
P
ASY
TL
------
ILIDG
-
-
------
VRQG
GS
S
D
V
T
PN
G
FSAM
N
T
GFM
PP
L
AA
IERIEV
I
RGP
M
S
T
LYG
S
D
A
M
GGVVNIIT
R
K
N
A
--------------
DK
W
LS
S
VN
A
GL
N
LQ
E
SN
K
W
---
G
----
NS
S
QF
NF
WSS
GPL
V
D
D
SVSL
Q
VR
G
STQ
Q
RQ
G
-
-
-------
SSVTSLSDTAA
T
R
I
PYPT
E
S-Q
N
Y
N
L
G
A
RL
--
D
WK
A
S
A
Q
D
V
L
WF
D
MDT
T
RQ
-----
---
R
YD
N
R
D
G
Q
LG
SL
TGG
-----------------
Y
D
R
T
L
R
Y
E
R
NKISAGYDHTFTF
G
-
TWKSYLN
W
NE
T
E
---------
N
KGRELVRSV
L
K
R
---
DKW
GL
A
G
QPR
-------
-
----
ELKE
S
NLILN
S
L
L
LT
P
L
G--ESH
L
V
T
V
G
G
E
F
QSS
S
MK
D
-------
-
------
-
--
-
G
VVLASTGETFRQ
K
SW
S
V
---
-
--
FAE
DEWH
LTD
A
L
A
L
T
V
G
S
RY
--------
E
H
------------
HEQF
G
G
----------
H
F
SP
RAY
L
VWD
V
A
D
A
W
T
LK
G
G
VT
T
GYKAP
R
M
G
Q
------
L
HKGIS
G
VS-
--
GQ
G
KTN
L
-----
L
GN
P
DLKPE
E
S
V
S
Y
E
A
G
VYYDNPA
GL
N
A
N
VT
G
F
M
TD
FS
NKIV
S
-------
Y
S
INDNTNS
Y
V
N
S
GKAR
LH
G
V
E
F
A
GTL
P
L
WSE
D
VTLSL
N
Y
TW
T
-------
-R
SEQ
RD
GDN
K
G
A
----
P
LS
Y
T
PE
H
M
V
NA
K
L
N
W
QIT
E
EVASWLGA
R
YR
GK
-T
P
RFT
Q
NY
SSLS
AV
QKKVY
D
EK
G
EYLKA
W
T
V
V
DA
GLS
WK
M
T
D
---
A
L
T
L
NAA
V
N
NL
LN
K
D
Y
SDVS
L
YSA
G
K
---
STLY
AG
DYFQT
G
S
S
T
---
T
G
Y
VI
P
E
RNY
W
MS
L
N
YQ
F
fig|749528.3.peg.4239
Escherichia coli MS 45-1
MIVSA
SGYEKKL
T
NA
AA
S
VSVI
SQ
EE
LQ
S
S
-
Q-YH
DL
A
E
A
LR
S
-
V
E
GV
D
V
--E
S
GT
G
KT
G
-
G
L
E
ISIRGM
P
ASY
TL
------
ILIDG
-
-
------
VRQG
GS
S
D
V
T
PN
G
FSAM
N
T
GFM
PP
L
AA
IERIEV
I
RGP
M
S
T
LYG
S
D
A
M
GGVVNIIT
R
K
N
A
--------------
DK
W
LS
S
VN
A
GL
N
LQ
E
SN
K
W
---
G
----
NS
S
QF
NF
WSS
GPL
V
D
D
SVSL
Q
VR
G
STQ
Q
RQ
G
-
-
-------
SSVTSLSDTAA
T
R
I
PYPT
E
S-Q
N
Y
N
L
G
A
RL
--
D
WK
A
S
A
Q
D
V
L
WF
D
MDT
T
RQ
-----
---
R
YD
N
R
D
G
Q
LG
SL
TGG
-----------------
Y
D
R
T
L
R
Y
E
R
NKISAGYDHTFTF
G
-
TWKSYLN
W
NE
T
E
---------
N
KGRELVRSV
L
K
R
---
DKW
GL
A
G
QPR
-------
-
----
ELKE
S
NLILN
S
L
L
LT
P
L
G--ESH
L
V
T
V
G
G
E
F
QSS
S
MK
D
-------
-
------
-
--
-
G
VVLASTGETFRQ
K
SW
S
V
---
-
--
FAE
DEWH
LTD
A
L
A
L
T
V
G
S
RY
--------
E
H
------------
HEQF
G
G
----------
H
F
SP
RAY
L
VWD
V
A
D
A
W
T
LK
G
G
VT
T
GYKAP
R
M
G
Q
------
L
HKGIS
G
VS-
--
GQ
G
KTN
L
-----
L
GN
P
DLKPE
E
S
V
S
Y
E
A
G
VYYDNPA
GL
N
A
N
VT
G
F
M
TD
FS
NKIV
S
-------
Y
S
INDNTNS
Y
V
N
S
GKAR
LH
G
V
E
F
A
GTL
P
L
WSE
D
VTLSL
N
Y
TW
T
-------
-R
SEQ
RD
GDN
K
G
A
----
P
LS
Y
T
PE
H
M
V
NA
K
L
N
W
QIT
E
EVASWLGA
R
YR
GK
-T
P
RFT
Q
NY
SSLS
AV
QKKVY
D
EK
G
EYLKA
W
T
V
V
DA
GLS
WK
M
T
D
---
A
L
T
L
NAA
V
N
NL
LN
K
D
Y
SDVS
L
YSA
G
K
---
STLY
AG
DYFQT
G
S
S
T
---
T
G
Y
VI
P
E
RNY
W
MS
L
N
YQ
F
fig|573235.3.peg.4164
Escherichia coli O26:H11 str. 11368
MIVSA
SGYEKKL
T
NA
AA
S
VSVI
SQ
EE
LQ
S
S
-
Q-YH
DL
A
E
A
LR
S
-
V
E
GV
D
V
--E
S
GT
G
KT
G
-
G
L
E
ISIRGM
P
ASY
TL
------
ILIDG
-
-
------
VRQG
GS
S
D
V
T
PN
G
FSAM
N
T
GFM
PP
L
AA
IERIEV
I
RGP
M
S
T
LYG
S
D
A
M
GGVVNIIT
R
K
N
A
--------------
DK
W
LS
S
VN
A
GL
N
LQ
E
SN
K
W
---
G
----
NS
S
QF
NF
WSS
GPL
V
D
D
SVSL
Q
VR
G
STQ
Q
RQ
G
-
-
-------
SSVTSLSDTAA
T
R
I
PYPT
E
S-Q
N
Y
N
L
G
A
RL
--
D
WK
A
S
E
Q
D
V
L
WF
D
MDT
T
RQ
-----
---
R
YD
N
R
D
G
Q
LG
SL
TGG
-----------------
Y
D
R
T
L
R
Y
E
R
NKISAGYDHTFTF
G
-
TWKSYLN
W
NE
T
E
---------
N
KGRELVRNV
L
K
R
---
DKW
GL
A
G
QLR
-------
-
----
ELKE
S
NLILN
S
L
L
LT
P
L
G--ESH
L
V
T
V
G
G
E
Y
QSS
S
MK
D
-------
-
------
-
--
-
G
VVLASTGETFRQ
K
SW
S
V
---
-
--
FAE
DEWH
LTD
A
L
A
L
T
AG
S
RY
--------
E
H
------------
HEQF
G
G
----------
H
F
SP
RAY
L
VWD
V
A
D
A
W
T
LK
G
G
VT
T
GYKAP
R
M
G
Q
------
L
HKGIS
G
VS-
--
GQ
G
KTN
L
-----
L
GN
P
DLKPE
E
S
V
S
Y
E
A
G
VYYDNPA
GL
N
A
N
I
T
G
F
M
TD
FS
NKIV
S
-------
Y
S
INDNTNS
Y
I
N
S
GKAR
LH
G
V
E
F
A
GTL
P
L
WSE
D
VTLSL
N
Y
TW
T
-------
-R
SEQ
RD
GDN
K
G
A
----
P
LS
Y
T
PE
H
M
V
NA
K
L
N
W
QIT
E
EVASWLGA
R
YR
GK
-T
P
RFT
Q
NY
SSLS
AV
QKKVY
D
EK
G
EYLKA
W
T
V
V
DA
GLS
WK
V
T
D
---
A
L
T
L
NAA
V
N
NL
LN
K
D
Y
SDVS
L
YSA
G
K
---
STLY
AG
DYFQT
G
S
S
T
---
T
G
Y
VI
P
E
RNY
W
MS
L
N
YQ
F
fig|585397.9.peg.3553
Escherichia coli ED1a (8-676/676)
MIVSA
SGYEKKL
T
NA
AA
S
VSVI
SQ
EE
LQ
S
R
-
Q-YH
DL
A
E
A
LR
S
-
V
E
GV
D
V
--E
S
GT
G
KT
G
-
G
L
E
ISIRGM
P
ASY
TL
------
ILIDG
-
-
------
VRQG
GS
S
D
V
T
PN
G
FSAM
N
T
GFM
PP
L
AA
IERIEV
I
RGP
M
S
T
LYG
S
D
A
M
GGVVNIIT
R
K
N
A
--------------
DK
W
LS
S
VN
A
GL
N
LQ
E
SN
K
W
---
G
----
NS
S
QF
NF
WTS
GPL
V
D
D
SVSL
Q
VR
G
STQ
Q
RQ
G
-
-
-------
SSVTSLSDTAA
T
R
I
PYPT
E
S-Q
N
Y
N
I
G
A
RL
--
D
WK
A
T
E
Q
D
V
L
WF
D
MDT
T
RQ
-----
---
R
YD
N
R
D
G
Q
LG
SL
TGG
-----------------
Y
D
R
T
L
R
Y
E
R
NKISAGYDHSFTF
G
-
TWKSYLN
W
NE
T
E
---------
N
KGRELVQSV
L
K
R
---
DKW
E
L
A
G
QPR
-------
-
----
ELKE
S
NFILN
S
L
L
LT
P
L
G--ESH
L
V
T
V
G
G
E
Y
QSS
S
MK
D
-------
-
------
-
--
-
G
VVLASTGETFRQ
K
SW
S
V
---
-
--
FAE
DEWH
LTD
A
L
A
L
T
AG
S
RY
--------
E
H
------------
HEQF
G
G
----------
H
F
SP
RAY
L
VWD
V
A
D
A
W
T
LK
G
G
VT
T
GYKAP
T
M
G
Q
------
L
HKGIS
G
VS-
--
GQ
G
RTN
L
-----
L
GN
P
E
LKPE
E
S
V
S
Y
E
A
G
VYYDNLS
GL
N
A
N
I
T
G
F
I
TD
FS
NKIV
S
-------
Y
S
IDDNTNS
Y
T
N
S
GKAR
LH
G
V
E
F
A
GTL
P
L
WSE
D
VTLSL
N
Y
TW
T
-------
-R
SEQ
RD
GDN
K
G
A
----
P
LS
Y
T
PE
H
M
V
NA
K
L
N
W
QIT
E
EVASWLGA
R
YR
D
K
-T
P
RFT
R
NY
SSLS
AV
QKKVY
D
EK
G
EYLKA
W
T
V
V
DA
GLS
WK
V
T
D
---
A
L
T
L
NAA
V
N
NL
LN
K
D
Y
SDVS
L
YSA
G
K
---
STLY
AG
DYFQT
G
S
S
T
---
T
G
Y
VI
P
E
RNY
W
MS
L
N
YQ
F
fig|585397.7.peg.3555
Escherichia coli ED1a
MIVSA
SGYEKKL
T
NA
AA
S
VSVI
SQ
EE
LQ
S
R
-
Q-YH
DL
A
E
A
LR
S
-
V
E
GV
D
V
--E
S
GT
G
KT
G
-
G
L
E
ISIRGM
P
ASY
TL
------
ILIDG
-
-
------
VRQG
GS
S
D
V
T
PN
G
FSAM
N
T
GFM
PP
L
AA
IERIEV
I
RGP
M
S
T
LYG
S
D
A
M
GGVVNIIT
R
K
N
A
--------------
DK
W
LS
S
VN
A
GL
N
LQ
E
SN
K
W
---
G
----
NS
S
QF
NF
WTS
GPL
V
D
D
SVSL
Q
VR
G
STQ
Q
RQ
G
-
-
-------
SSVTSLSDTAA
T
R
I
PYPT
E
S-Q
N
Y
N
I
G
A
RL
--
D
WK
A
T
E
Q
D
V
L
WF
D
MDT
T
RQ
-----
---
R
YD
N
R
D
G
Q
LG
SL
TGG
-----------------
Y
D
R
T
L
R
Y
E
R
NKISAGYDHSFTF
G
-
TWKSYLN
W
NE
T
E
---------
N
KGRELVQSV
L
K
R
---
DKW
E
L
A
G
QPR
-------
-
----
ELKE
S
NFILN
S
L
L
LT
P
L
G--ESH
L
V
T
V
G
G
E
Y
QSS
S
MK
D
-------
-
------
-
--
-
G
VVLASTGETFRQ
K
SW
S
V
---
-
--
FAE
DEWH
LTD
A
L
A
L
T
AG
S
RY
--------
E
H
------------
HEQF
G
G
----------
H
F
SP
RAY
L
VWD
V
A
D
A
W
T
LK
G
G
VT
T
GYKAP
T
M
G
Q
------
L
HKGIS
G
VS-
--
GQ
G
RTN
L
-----
L
GN
P
E
LKPE
E
S
V
S
Y
E
A
G
VYYDNLS
GL
N
A
N
I
T
G
F
I
TD
FS
NKIV
S
-------
Y
S
IDDNTNS
Y
T
N
S
GKAR
LH
G
V
E
F
A
GTL
P
L
WSE
D
VTLSL
N
Y
TW
T
-------
-R
SEQ
RD
GDN
K
G
A
----
P
LS
Y
T
PE
H
M
V
NA
K
L
N
W
QIT
E
EVASWLGA
R
YR
D
K
-T
P
RFT
R
NY
SSLS
AV
QKKVY
D
EK
G
EYLKA
W
T
V
V
DA
GLS
WK
V
T
D
---
A
L
T
L
NAA
V
N
NL
LN
K
D
Y
SDVS
L
YSA
G
K
---
STLY
AG
DYFQT
G
S
S
T
---
T
G
Y
VI
P
E
RNY
W
MS
L
N
YQ
F
fig|439855.10.peg.3286
Escherichia coli SMS-3-5 (7-675/675)
M
V
V
T
A
SGYEKKL
T
SA
AA
S
VSVI
SQ
E
DL
R
S
S
-
Q-YH
DL
G
E
A
LR
S
-
V
E
GV
D
V
--E
S
GT
G
KT
G
-
G
L
E
ISIRGM
P
ASY
TL
------
ILIDG
-
-
------
VRQG
GS
S
D
V
T
PN
G
YA
AM
N
T
GFM
PP
L
AA
IERIE
I
I
RGP
M
S
T
LYG
S
D
A
M
GGVVNIITKK
N
A
--------------
DK
W
RS
S
VN
A
GL
N
LQ
E
SN
K
W
---
G
----
NS
S
QF
NF
WSS
GPL
V
D
D
SLSL
Q
VR
G
STQ
Q
RQ
G
-
-
-------
SSVTSLSDTSA
T
R
I
PYPT
E
S-Q
N
Y
N
A
GG
RL
--
D
WK
A
TD
K
D
V
L
WI
D
MDI
A
RQ
-----
---
R
YD
N
R
D
G
Q
LG
SL
TGG
-----------------
Y
D
R
T
L
R
Y
E
R
NKISAGYDHTFTF
G
-
AWKSSLN
W
NE
T
E
---------
N
KGRQLVRSV
L
Q
R
---
DKW
GL
A
G
QPR
-------
-
----
ELKE
S
NLILS
S
L
L
FA
P
L
G--ESH
K
V
T
V
G
G
E
Y
QNS
S
MK
D
-------
-
------
-
--
-
G
VVLASTGETFRQ
K
SW
S
A
---
-
--
F
V
E
DEWY
I
TD
A
F
A
L
T
AG
S
RY
--------
E
R
------------
YEVF
G
G
----------
H
F
SP
RAY
M
VWD
V
T
D
A
W
T
LK
G
G
VT
T
GYKAP
S
M
G
Q
------
L
HKGIS
G
VS-
--
GQ
G
RTN
L
-----
L
GN
P
DLKPE
E
S
V
S
Y
E
A
G
VYYDNHA
GL
N
A
N
I
T
G
F
M
T
E
FS
NKIV
S
-------
Y
S
IDDNTRS
Y
T
N
S
GKAR
TQ
G
V
E
F
A
GTL
P
L
LSE
D
VTLSL
N
Y
TW
T
-------
-Q
SEQ
RD
GDN
K
G
A
----
P
LS
Y
T
PE
H
M
V
NA
K
L
N
W
QIT
E
EVTSWLGA
R
YR
GK
-T
P
RFT
Q
NY
SSLS
AV
QKKVY
D
EK
G
EYLKA
W
T
VL
DA
GMS
WK
V
T
D
---
A
L
M
L
NAA
V
N
N
V
LN
K
D
Y
SDVS
L
YRA
G
S
---
GTLY
AG
DYFQT
G
A
S
T
---
T
G
Y
VI
P
E
RNY
W
MS
L
N
YQ
F
fig|331111.12.peg.909
Escherichia coli E24377A (47-746/746)
A
P
G
VS
T
I
TA
D
EIR
K
N
-
PVAR
D
V
SE
I
I
R
T
-
M
PGV
N
L
TGN
S
TS
G
QR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
K
P
VSSRNS
VRQG
WR
G
E
R
D
TR
G
----
D
T
SWV
PP
-
EM
IERIEVLRGP
A
A
A
R
YGN
G
A
A
GGVVNIITKKG
S
--------------
GE
W
HG
S
WD
A
YF
N
AP
E
HK
E
E
---
G
----
AT
K
RT
NF
SLT
GPL
-
G
D
EFSF
R
LY
G
NLD
K
TQ
A
D
A
WDINQ
--
GHQSARAGTYA
T
T
L
PAGR
E
GVI
N
K
D
I
N
G
VV
--
R
W
D
F
A
P
L
Q
S
L
EL
E
AGY
SRQ
GNLYA
GDT
Q
NT
N
S
D
A
Y
TR
S
-
-KY
-----------------
G
D
E
T
N
R
L
YR
QNYSLTWNGGWDN
G
V
TTSNWVQ
Y
EH
T
R
---------
N
---------
-
S
R
---
IPE
GL
A
G
GTE
GKFNEKA
T
QDFV
DIDL
D
DVMLH
SE
V
NL
P
L
DFLVNQ
T
L
T
L
G
T
EW
NQQ
R
MK
D
LSSNTQA
L
TGTNTG
G
AI
D
G
VSATDRSPYSKA
E
IF
SL
---
-
--
FAE
NNME
LTD
S
T
I
V
T
P
G
L
R
F
--------
DH
------------
HSIV
GN
----------
N
WSP
ALN
I
SQG
L
G
D
D
F
T
LK
M
G
IA
R
A
YKAP
S
L
Y
Q
TNPNYI
L
YSKGQ
G
CYA
--
SA
G
GCY
L
-----
Q
GN
D
DLK
A
E
T
S
I
N
K
EIG
LEF-KRD
G
W
L
A
G
VT
W
F
R
N
D
YR
NKI
E
A
GYVAVGQ
N
A
VGTDLYQ
W
D
N
V
P
KA
V
VE
G
L
E
G
S
LNV
P
-
VSE
T
VMWTN
N
I
T
Y
M
-------
LK
SE
N
KT
---
T
G
D
----
RLS
I
IPEY
T
L
N
S
T
L
S
W
QAR
E
DLSMQTTF
T
WY
GK
QQ
P
KKY
-
NY
KGQP
AV
-----
G
PE
T
KEISP
Y
S
I
VGL
SAT
W
D
V
T
K
---
N
V
S
L
TGG
VDNLFDK
-
-
---R
L
WRA
G
N
AQT
TGDL
AG
ANYIA
G
A
G
A
---
Y
T
Y
NE
PGR
TW
Y
MSVN
TH
F
fig|331111.3.peg.3133
Escherichia coli E24377A (47-746/746)
A
P
G
VS
T
I
TA
D
EIR
K
N
-
PVAR
D
V
SE
I
I
R
T
-
M
PGV
N
L
TGN
S
TS
G
QR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
K
P
VSSRNS
VRQG
WR
G
E
R
D
TR
G
----
D
T
SWV
PP
-
EM
IERIEVLRGP
A
A
A
R
YGN
G
A
A
GGVVNIITKKG
S
--------------
GE
W
HG
S
WD
A
YF
N
AP
E
HK
E
E
---
G
----
AT
K
RT
NF
SLT
GPL
-
G
D
EFSF
R
LY
G
NLD
K
TQ
A
D
A
WDINQ
--
GHQSARAGTYA
T
T
L
PAGR
E
GVI
N
K
D
I
N
G
VV
--
R
W
D
F
A
P
L
Q
S
L
EL
E
AGY
SRQ
GNLYA
GDT
Q
NT
N
S
D
A
Y
TR
S
-
-KY
-----------------
G
D
E
T
N
R
L
YR
QNYSLTWNGGWDN
G
V
TTSNWVQ
Y
EH
T
R
---------
N
---------
-
S
R
---
IPE
GL
A
G
GTE
GKFNEKA
T
QDFV
DIDL
D
DVMLH
SE
V
NL
P
L
DFLVNQ
T
L
T
L
G
T
EW
NQQ
R
MK
D
LSSNTQA
L
TGTNTG
G
AI
D
G
VSATDRSPYSKA
E
IF
SL
---
-
--
FAE
NNME
LTD
S
T
I
V
T
P
G
L
R
F
--------
DH
------------
HSIV
GN
----------
N
WSP
ALN
I
SQG
L
G
D
D
F
T
LK
M
G
IA
R
A
YKAP
S
L
Y
Q
TNPNYI
L
YSKGQ
G
CYA
--
SA
G
GCY
L
-----
Q
GN
D
DLK
A
E
T
S
I
N
K
EIG
LEF-KRD
G
W
L
A
G
VT
W
F
R
N
D
YR
NKI
E
A
GYVAVGQ
N
A
VGTDLYQ
W
D
N
V
P
KA
V
VE
G
L
E
G
S
LNV
P
-
VSE
T
VMWTN
N
I
T
Y
M
-------
LK
SE
N
KT
---
T
G
D
----
RLS
I
IPEY
T
L
N
S
T
L
S
W
QAR
E
DLSMQTTF
T
WY
GK
QQ
P
KKY
-
NY
KGQP
AV
-----
G
PE
T
KEISP
Y
S
I
VGL
SAT
W
D
V
T
K
---
N
V
S
L
TGG
VDNLFDK
-
-
---R
L
WRA
G
N
AQT
TGDL
AG
ANYIA
G
A
G
A
---
Y
T
Y
NE
PGR
TW
Y
MSVN
TH
F
fig|679205.4.peg.587
Escherichia coli MS 124-1 (47-746/746)
A
P
G
VS
T
I
TA
D
EIR
K
N
-
PVAR
D
V
SE
I
I
R
T
-
M
PGV
N
L
TGN
S
TS
G
QR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
K
P
VSSRNS
VRQG
WR
G
E
R
D
TR
G
----
D
T
SWV
PP
-
EM
IERIEVLRGP
A
A
A
R
YGN
G
A
A
GGVVNIITKKG
S
--------------
GE
W
HG
S
WD
A
YF
N
AP
E
HK
E
E
---
G
----
AT
K
RT
NF
SLT
GPL
-
G
D
EFSF
R
LY
G
NLD
K
TQ
A
D
A
WDINQ
--
GHQSARAGTYA
T
T
L
PAGR
E
GVI
N
K
D
I
N
G
VV
--
R
W
D
F
A
P
L
Q
S
L
EL
E
AGY
SRQ
GNLYA
GDT
Q
NT
N
S
D
A
Y
TR
S
-
-KY
-----------------
G
D
E
T
N
R
L
YR
QNYSLTWNGGWDN
G
V
TTSNWVQ
Y
EH
T
R
---------
N
---------
-
S
R
---
IPE
GL
A
G
GTE
GKFNEKA
T
QDFV
DIDL
D
DVMLH
SE
V
NL
P
L
DFLVNQ
T
L
T
L
G
T
EW
NQQ
R
MK
D
LSSNTQA
L
TGTNTG
G
AI
D
G
VSATDRSPYSKA
E
IF
SL
---
-
--
FAE
NNME
LTD
S
T
I
V
T
P
G
L
R
F
--------
DH
------------
HSIV
GN
----------
N
WSP
ALN
I
SQG
L
G
D
D
F
T
LK
M
G
IA
R
A
YKAP
S
L
Y
Q
TNPNYI
L
YSKGQ
G
CYA
--
SA
G
GCY
L
-----
Q
GN
D
DLK
A
E
T
S
I
N
K
EIG
LEF-KRD
G
W
L
A
G
VT
W
F
R
N
D
YR
NKI
E
A
GYVAVGQ
N
A
VGTDLYQ
W
D
N
V
P
KA
V
VE
G
L
E
G
S
LNV
P
-
VSE
T
VMWTN
N
I
T
Y
M
-------
LK
SE
N
KT
---
T
G
D
----
RLS
I
IPEY
T
L
N
S
T
L
S
W
QAR
E
DLSMQTTF
T
WY
GK
QQ
P
KKY
-
NY
KGQP
AV
-----
G
PE
T
KEISP
Y
S
I
VGL
SAT
W
D
V
T
K
---
N
V
S
L
TGG
VDNLFDK
-
-
---R
L
WRA
G
N
AQT
TGDL
AG
ANYIA
G
A
G
A
---
Y
T
Y
NE
PGR
TW
Y
MSVN
TH
F
fig|749533.3.peg.5391
Escherichia coli MS 84-1 (47-746/746)
A
P
G
VS
T
I
TA
D
EIR
K
N
-
PVAR
D
V
SE
I
I
R
T
-
M
PGV
N
L
TGN
S
TS
G
QR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
K
P
VSSRNS
VRQG
WR
G
E
R
D
TR
G
----
D
T
SWV
PP
-
EM
IERIEVLRGP
A
A
A
R
YGN
G
A
A
GGVVNIITKKG
S
--------------
GE
W
HG
S
WD
A
YF
N
AP
E
HK
E
E
---
G
----
AT
K
RT
NF
SLT
GPL
-
G
D
EFSF
R
LY
G
NLD
K
TQ
A
D
A
WDINQ
--
GHQSARAGTYA
T
T
L
PAGR
E
GVI
N
K
D
I
N
G
VV
--
R
W
D
F
A
P
L
Q
S
L
EL
E
AGY
SRQ
GNLYA
GDT
Q
NT
N
S
D
A
Y
TR
S
-
-KY
-----------------
G
D
E
T
N
R
L
YR
QNYSLTWNGGWDN
G
V
TTSNWVQ
Y
EH
T
R
---------
N
---------
-
S
R
---
IPE
GL
A
G
GTE
GKFNEKA
T
QDFV
DIDL
D
DVMLH
SE
V
NL
P
L
DFLVNQ
T
L
T
L
G
T
EW
NQQ
R
MK
D
LSSNTQA
L
TGTNTG
G
AI
D
G
VSATDRSPYSKA
E
IF
SL
---
-
--
FAE
NNME
LTD
S
T
I
V
T
P
G
L
R
F
--------
DH
------------
HSIV
GN
----------
N
WSP
ALN
I
SQG
L
G
D
D
F
T
LK
M
G
IA
R
A
YKAP
S
L
Y
Q
TNPNYI
L
YSKGQ
G
CYA
--
SA
G
GCY
L
-----
Q
GN
D
DLK
A
E
T
S
I
N
K
EIG
LEF-KRD
G
W
L
A
G
VT
W
F
R
N
D
YR
NKI
E
A
GYVAVGQ
N
A
VGTDLYQ
W
D
N
V
P
KA
V
VE
G
L
E
G
S
LNV
P
-
VSE
T
VMWTN
N
I
T
Y
M
-------
LK
SE
N
KT
---
T
G
D
----
RLS
I
IPEY
T
L
N
S
T
L
S
W
QAR
E
DLSMQTTF
T
WY
GK
QQ
P
KKY
-
NY
KGQP
AV
-----
G
PE
T
KEISP
Y
S
I
VGL
SAT
W
D
V
T
K
---
N
V
S
L
TGG
VDNLFDK
-
-
---R
L
WRA
G
N
AQT
TGDL
AG
ANYIA
G
A
G
A
---
Y
T
Y
NE
PGR
TW
Y
MSVN
TH
F
fig|409438.11.peg.774
Escherichia coli SE11 (47-746/746)
A
P
G
VS
T
I
TA
D
EIR
K
N
-
PVAR
D
V
SE
I
I
R
T
-
M
PGV
N
L
TGN
S
TS
G
QR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
K
P
VSSRNS
VRQG
WR
G
E
R
D
TR
G
----
D
T
SWV
PP
-
EM
IERIEVLRGP
A
A
A
R
YGN
G
A
A
GGVVNIITKKG
S
--------------
GE
W
HG
S
WD
A
YF
N
AP
E
HK
E
E
---
G
----
AT
K
RT
NF
SLT
GPL
-
G
D
EFSF
R
LY
G
NLD
K
TQ
A
D
A
WDINQ
--
GHQSARAGTYA
T
T
L
PAGR
E
GVI
N
K
D
I
N
G
VV
--
R
W
D
F
A
P
L
Q
S
L
EL
E
AGY
SRQ
GNLYA
GDT
Q
NT
N
S
D
A
Y
TR
S
-
-KY
-----------------
G
D
E
T
N
R
L
YR
QNYSLTWNGGWDN
G
V
TTSNWVQ
Y
EH
T
R
---------
N
---------
-
S
R
---
IPE
GL
A
G
GTE
GKFNEKA
T
QDFV
DIDL
D
DVMLH
SE
V
NL
P
L
DFLVNQ
T
L
T
L
G
T
EW
NQQ
R
MK
D
LSSNTQA
L
TGTNTG
G
AI
D
G
VSATDRSPYSKA
E
IF
SL
---
-
--
FAE
NNME
LTD
S
T
I
V
T
P
G
L
R
F
--------
DH
------------
HSIV
GN
----------
N
WSP
ALN
I
SQG
L
G
D
D
F
T
LK
M
G
IA
R
A
YKAP
S
L
Y
Q
TNPNYI
L
YSKGQ
G
CYA
--
SA
G
GCY
L
-----
Q
GN
D
DLK
A
E
T
S
I
N
K
EIG
LEF-KRD
G
W
L
A
G
VT
W
F
R
N
D
YR
NKI
E
A
GYVAVGQ
N
A
VGTDLYQ
W
D
N
V
P
KA
V
VE
G
L
E
G
S
LNV
P
-
VSE
T
VMWTN
N
I
T
Y
M
-------
LK
SE
N
KT
---
T
G
D
----
RLS
I
IPEY
T
L
N
S
T
L
S
W
QAR
E
DLSMQTTF
T
WY
GK
QQ
P
KKY
-
NY
KGQP
AV
-----
G
PE
T
KEISP
Y
S
I
VGL
SAT
W
D
V
T
K
---
N
V
S
L
TGG
VDNLFDK
-
-
---R
L
WRA
G
N
AQT
TGDL
AG
ANYIA
G
A
G
A
---
Y
T
Y
NE
PGR
TW
Y
MSVN
TH
F
fig|362663.8.peg.618
Escherichia coli 536 (72-771/771)
A
P
G
VS
T
I
TA
D
EIR
K
N
-
PVAR
D
V
SE
I
I
R
T
-
M
PGV
N
L
TGN
S
TS
G
QR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
K
P
VSSRNS
VRQG
WR
G
E
R
D
TR
G
----
D
T
SWV
PP
-
EM
IERIEVLRGP
A
A
A
R
YGN
G
A
A
GGVVNIITKKG
S
--------------
GE
W
HG
S
WD
A
YF
N
AP
E
HK
E
E
---
G
----
AT
K
RT
NF
SLT
GPL
-
G
D
EFSF
R
LY
G
NLD
K
TQ
A
D
A
WDINQ
--
GHQSARAGTYA
T
T
L
PAGR
E
GVI
N
K
D
I
N
G
VV
--
R
W
D
F
A
P
L
Q
S
L
EL
E
AGY
SRQ
GNLYA
GDT
Q
NT
N
S
D
A
Y
TR
S
-
-KY
-----------------
G
D
E
T
N
R
L
YR
QNYSLTWNGGWDN
G
V
TTSNWVQ
Y
EH
T
R
---------
N
---------
-
S
R
---
IPE
GL
A
G
GTE
GKFNEKA
A
QDFV
DIDL
D
DVMLH
SE
V
NL
PI
DFLVNQ
T
L
T
L
G
T
EW
NQQ
R
MK
D
LSSNTQA
L
TGTNTG
G
AI
D
G
VSATDRSPYSKA
E
IF
SL
---
-
--
FAE
NNME
LTD
S
T
I
V
T
P
G
L
R
F
--------
DH
------------
HSIV
GN
----------
N
WSP
ALN
I
SQS
L
G
D
D
F
T
LK
M
G
IA
R
A
YKAP
S
L
Y
Q
TNPNYI
L
YSKGQ
G
CYA
--
SA
G
GCY
L
-----
Q
GN
D
DLK
A
E
T
S
I
N
K
EIG
LEF-KRD
G
W
L
A
G
VT
W
F
R
N
D
YR
NKI
E
A
GYVAVGQ
N
A
VGTDLYQ
W
D
N
V
P
KA
V
VE
G
L
E
G
S
LNV
P
-
VSE
T
VMWTN
N
I
T
Y
M
-------
LK
SE
N
KT
---
T
G
D
----
RLS
I
IPEY
T
L
N
S
T
L
S
W
QAR
E
DLSMQTTF
T
WY
GK
QQ
P
KKY
-
NY
KGQP
AV
-----
G
PE
T
KEISP
Y
S
I
VGL
SAT
W
D
V
T
K
---
N
V
S
L
TGG
VDNLFDK
-
-
---R
L
WRA
G
N
AQT
TGDL
AG
ANYIA
G
A
G
A
---
Y
T
Y
NE
PGR
TW
Y
MS
I
N
TH
F
fig|362663.9.peg.619
Escherichia coli 536 (72-771/771)
A
P
G
VS
T
I
TA
D
EIR
K
N
-
PVAR
D
V
SE
I
I
R
T
-
M
PGV
N
L
TGN
S
TS
G
QR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
K
P
VSSRNS
VRQG
WR
G
E
R
D
TR
G
----
D
T
SWV
PP
-
EM
IERIEVLRGP
A
A
A
R
YGN
G
A
A
GGVVNIITKKG
S
--------------
GE
W
HG
S
WD
A
YF
N
AP
E
HK
E
E
---
G
----
AT
K
RT
NF
SLT
GPL
-
G
D
EFSF
R
LY
G
NLD
K
TQ
A
D
A
WDINQ
--
GHQSARAGTYA
T
T
L
PAGR
E
GVI
N
K
D
I
N
G
VV
--
R
W
D
F
A
P
L
Q
S
L
EL
E
AGY
SRQ
GNLYA
GDT
Q
NT
N
S
D
A
Y
TR
S
-
-KY
-----------------
G
D
E
T
N
R
L
YR
QNYSLTWNGGWDN
G
V
TTSNWVQ
Y
EH
T
R
---------
N
---------
-
S
R
---
IPE
GL
A
G
GTE
GKFNEKA
A
QDFV
DIDL
D
DVMLH
SE
V
NL
PI
DFLVNQ
T
L
T
L
G
T
EW
NQQ
R
MK
D
LSSNTQA
L
TGTNTG
G
AI
D
G
VSATDRSPYSKA
E
IF
SL
---
-
--
FAE
NNME
LTD
S
T
I
V
T
P
G
L
R
F
--------
DH
------------
HSIV
GN
----------
N
WSP
ALN
I
SQS
L
G
D
D
F
T
LK
M
G
IA
R
A
YKAP
S
L
Y
Q
TNPNYI
L
YSKGQ
G
CYA
--
SA
G
GCY
L
-----
Q
GN
D
DLK
A
E
T
S
I
N
K
EIG
LEF-KRD
G
W
L
A
G
VT
W
F
R
N
D
YR
NKI
E
A
GYVAVGQ
N
A
VGTDLYQ
W
D
N
V
P
KA
V
VE
G
L
E
G
S
LNV
P
-
VSE
T
VMWTN
N
I
T
Y
M
-------
LK
SE
N
KT
---
T
G
D
----
RLS
I
IPEY
T
L
N
S
T
L
S
W
QAR
E
DLSMQTTF
T
WY
GK
QQ
P
KKY
-
NY
KGQP
AV
-----
G
PE
T
KEISP
Y
S
I
VGL
SAT
W
D
V
T
K
---
N
V
S
L
TGG
VDNLFDK
-
-
---R
L
WRA
G
N
AQT
TGDL
AG
ANYIA
G
A
G
A
---
Y
T
Y
NE
PGR
TW
Y
MS
I
N
TH
F
fig|340197.3.peg.2421
Escherichia coli F11 (50-749/749)
A
P
G
VS
T
I
TA
D
EIR
K
N
-
PVAR
D
V
SE
I
I
R
T
-
M
PGV
N
L
TGN
S
TS
G
QR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
K
P
VSSRNS
VRQG
WR
G
E
R
D
TR
G
----
D
T
SWV
PP
-
EM
IERIEVLRGP
A
A
A
R
YGN
G
A
A
GGVVNIITKKG
S
--------------
GE
W
HG
S
WD
A
YF
N
AP
E
HK
E
E
---
G
----
AT
K
RT
NF
SLT
GPL
-
G
D
EFSF
R
LY
G
NLD
K
TQ
A
D
A
WDINQ
--
GHQSARAGTYA
T
T
L
PAGR
E
GVI
N
K
D
I
N
G
VV
--
R
W
D
F
A
P
L
Q
S
L
EL
E
AGY
SRQ
GNLYA
GDT
Q
NT
N
S
D
A
Y
TR
S
-
-KY
-----------------
G
D
E
T
N
R
L
YR
QNYSLTWNGGWDN
G
V
TTSNWVQ
Y
EH
T
R
---------
N
---------
-
S
R
---
IPE
GL
A
G
GTE
GKFNEKA
A
QDFV
DIDL
D
DVMLH
SE
V
NL
PI
DFLVNQ
T
L
T
L
G
T
EW
NQQ
R
MK
D
LSSNTQA
L
TGTNTG
G
AI
D
G
VSATDRSPYSKA
E
IF
SL
---
-
--
FAE
NNME
LTD
S
T
I
V
T
P
G
L
R
F
--------
DH
------------
HSIV
GN
----------
N
WSP
ALN
I
SQS
L
G
D
D
F
T
LK
M
G
IA
R
A
YKAP
S
L
Y
Q
TNPNYI
L
YSKGQ
G
CYA
--
SA
G
GCY
L
-----
Q
GN
D
DLK
A
E
T
S
I
N
K
EIG
LEF-KRD
G
W
L
A
G
VT
W
F
R
N
D
YR
NKI
E
A
GYVAVGQ
N
A
VGTDLYQ
W
D
N
V
P
KA
V
VE
G
L
E
G
S
LNV
P
-
VSE
T
VMWTN
N
I
T
Y
M
-------
LK
SE
N
KT
---
T
G
D
----
RLS
I
IPEY
T
L
N
S
T
L
S
W
QAR
E
DLSMQTTF
T
WY
GK
QQ
P
KKY
-
NY
KGQP
AV
-----
G
PE
T
KEISP
Y
S
I
VGL
SAT
W
D
V
T
K
---
N
V
S
L
TGG
VDNLFDK
-
-
---R
L
WRA
G
N
AQT
TGDL
AG
ANYIA
G
A
G
A
---
Y
T
Y
NE
PGR
TW
Y
MS
I
N
TH
F
fig|340197.5.peg.2540
Escherichia coli F11 (72-771/771)
A
P
G
VS
T
I
TA
D
EIR
K
N
-
PVAR
D
V
SE
I
I
R
T
-
M
PGV
N
L
TGN
S
TS
G
QR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
K
P
VSSRNS
VRQG
WR
G
E
R
D
TR
G
----
D
T
SWV
PP
-
EM
IERIEVLRGP
A
A
A
R
YGN
G
A
A
GGVVNIITKKG
S
--------------
GE
W
HG
S
WD
A
YF
N
AP
E
HK
E
E
---
G
----
AT
K
RT
NF
SLT
GPL
-
G
D
EFSF
R
LY
G
NLD
K
TQ
A
D
A
WDINQ
--
GHQSARAGTYA
T
T
L
PAGR
E
GVI
N
K
D
I
N
G
VV
--
R
W
D
F
A
P
L
Q
S
L
EL
E
AGY
SRQ
GNLYA
GDT
Q
NT
N
S
D
A
Y
TR
S
-
-KY
-----------------
G
D
E
T
N
R
L
YR
QNYSLTWNGGWDN
G
V
TTSNWVQ
Y
EH
T
R
---------
N
---------
-
S
R
---
IPE
GL
A
G
GTE
GKFNEKA
A
QDFV
DIDL
D
DVMLH
SE
V
NL
PI
DFLVNQ
T
L
T
L
G
T
EW
NQQ
R
MK
D
LSSNTQA
L
TGTNTG
G
AI
D
G
VSATDRSPYSKA
E
IF
SL
---
-
--
FAE
NNME
LTD
S
T
I
V
T
P
G
L
R
F
--------
DH
------------
HSIV
GN
----------
N
WSP
ALN
I
SQS
L
G
D
D
F
T
LK
M
G
IA
R
A
YKAP
S
L
Y
Q
TNPNYI
L
YSKGQ
G
CYA
--
SA
G
GCY
L
-----
Q
GN
D
DLK
A
E
T
S
I
N
K
EIG
LEF-KRD
G
W
L
A
G
VT
W
F
R
N
D
YR
NKI
E
A
GYVAVGQ
N
A
VGTDLYQ
W
D
N
V
P
KA
V
VE
G
L
E
G
S
LNV
P
-
VSE
T
VMWTN
N
I
T
Y
M
-------
LK
SE
N
KT
---
T
G
D
----
RLS
I
IPEY
T
L
N
S
T
L
S
W
QAR
E
DLSMQTTF
T
WY
GK
QQ
P
KKY
-
NY
KGQP
AV
-----
G
PE
T
KEISP
Y
S
I
VGL
SAT
W
D
V
T
K
---
N
V
S
L
TGG
VDNLFDK
-
-
---R
L
WRA
G
N
AQT
TGDL
AG
ANYIA
G
A
G
A
---
Y
T
Y
NE
PGR
TW
Y
MS
I
N
TH
F
fig|749550.3.peg.4864
Escherichia coli MS 200-1 (72-771/771)
A
P
G
VS
T
I
TA
D
EIR
K
N
-
PVAR
D
V
SE
I
I
R
T
-
M
PGV
N
L
TGN
S
TS
G
QR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
K
P
VSSRNS
VRQG
WR
G
E
R
D
TR
G
----
D
T
SWV
PP
-
EM
IERIEVLRGP
A
A
A
R
YGN
G
A
A
GGVVNIITKKG
S
--------------
GE
W
HG
S
WD
A
YF
N
AP
E
HK
E
E
---
G
----
AT
K
RT
NF
SLT
GPL
-
G
D
EFSF
R
LY
G
NLD
K
TQ
A
D
A
WDINQ
--
GHQSARAGTYA
T
T
L
PAGR
E
GVI
N
K
D
I
N
G
VV
--
R
W
D
F
A
P
L
Q
S
L
EL
E
AGY
SRQ
GNLYA
GDT
Q
NT
N
S
D
A
Y
TR
S
-
-KY
-----------------
G
D
E
T
N
R
L
YR
QNYSLTWNGGWDN
G
V
TTSNWVQ
Y
EH
T
R
---------
N
---------
-
S
R
---
IPE
GL
A
G
GTE
GKFNEKA
A
QDFV
DIDL
D
DVMLH
SE
V
NL
PI
DFLVNQ
T
L
T
L
G
T
EW
NQQ
R
MK
D
LSSNTQA
L
TGTNTG
G
AI
D
G
VSATDRSPYSKA
E
IF
SL
---
-
--
FAE
NNME
LTD
S
T
I
V
T
P
G
L
R
F
--------
DH
------------
HSIV
GN
----------
N
WSP
ALN
I
SQS
L
G
D
D
F
T
LK
M
G
IA
R
A
YKAP
S
L
Y
Q
TNPNYI
L
YSKGQ
G
CYA
--
SA
G
GCY
L
-----
Q
GN
D
DLK
A
E
T
S
I
N
K
EIG
LEF-KRD
G
W
L
A
G
VT
W
F
R
N
D
YR
NKI
E
A
GYVAVGQ
N
A
VGTDLYQ
W
D
N
V
P
KA
V
VE
G
L
E
G
S
LNV
P
-
VSE
T
VMWTN
N
I
T
Y
M
-------
LK
SE
N
KT
---
T
G
D
----
RLS
I
IPEY
T
L
N
S
T
L
S
W
QAR
E
DLSMQTTF
T
WY
GK
QQ
P
KKY
-
NY
KGQP
AV
-----
G
PE
T
KEISP
Y
S
I
VGL
SAT
W
D
V
T
K
---
N
V
S
L
TGG
VDNLFDK
-
-
---R
L
WRA
G
N
AQT
TGDL
AG
ANYIA
G
A
G
A
---
Y
T
Y
NE
PGR
TW
Y
MS
I
N
TH
F
fig|753642.3.peg.1073
Escherichia coli NC101 (72-771/771)
A
P
G
VS
T
I
TA
D
EIR
K
N
-
PVAR
D
V
SE
I
I
R
T
-
M
PGV
N
L
TGN
S
TS
G
QR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
K
P
VSSRNS
VRQG
WR
G
E
R
D
TR
G
----
D
T
SWV
PP
-
EM
IERIEVLRGP
A
A
A
R
YGN
G
A
A
GGVVNIITKKG
S
--------------
GE
W
HG
S
WD
A
YF
N
AP
E
HK
E
E
---
G
----
AT
K
RT
NF
SLT
GPL
-
G
D
EFSF
R
LY
G
NLD
K
TQ
A
D
A
WDINQ
--
GHQSARAGTYA
T
T
L
PAGR
E
GVI
N
K
D
I
N
G
VV
--
R
W
D
F
A
P
L
Q
S
L
EL
E
AGY
SRQ
GNLYA
GDT
Q
NT
N
S
D
A
Y
TR
S
-
-KY
-----------------
G
D
E
T
N
R
L
YR
QNYSLTWNGGWDN
G
V
TTSNWVQ
Y
EH
T
R
---------
N
---------
-
S
R
---
IPE
GL
A
G
GTE
GKFNEKA
A
QDFV
DIDL
D
DVMLH
SE
V
NL
PI
DFLVNQ
T
L
T
L
G
T
EW
NQQ
R
MK
D
LSSNTQA
L
TGTNTG
G
AI
D
G
VSATDRSPYSKA
E
IF
SL
---
-
--
FAE
NNME
LTD
S
T
I
V
T
P
G
L
R
F
--------
DH
------------
HSIV
GN
----------
N
WSP
ALN
I
SQS
L
G
D
D
F
T
LK
M
G
IA
R
A
YKAP
S
L
Y
Q
TNPNYI
L
YSKGQ
G
CYA
--
SA
G
GCY
L
-----
Q
GN
D
DLK
A
E
T
S
I
N
K
EIG
LEF-KRD
G
W
L
A
G
VT
W
F
R
N
D
YR
NKI
E
A
GYVAVGQ
N
A
VGTDLYQ
W
D
N
V
P
KA
V
VE
G
L
E
G
S
LNV
P
-
VSE
T
VMWTN
N
I
T
Y
M
-------
LK
SE
N
KT
---
T
G
D
----
RLS
I
IPEY
T
L
N
S
T
L
S
W
QAR
E
DLSMQTTF
T
WY
GK
QQ
P
KKY
-
NY
KGQP
AV
-----
G
PE
T
KEISP
Y
S
I
VGL
SAT
W
D
V
T
K
---
N
V
S
L
TGG
VDNLFDK
-
-
---R
L
WRA
G
N
AQT
TGDL
AG
ANYIA
G
A
G
A
---
Y
T
Y
NE
PGR
TW
Y
MS
I
N
TH
F
fig|685038.3.peg.529
Escherichia coli O83:H1 str. NRG 857C (72-771/771)
A
P
G
VS
T
I
TA
D
EIR
K
N
-
PVAR
D
V
SE
I
I
R
T
-
M
PGV
N
L
TGN
S
TS
G
QR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
K
P
VSSRNS
VRQG
WR
G
E
R
D
TR
G
----
D
T
SWV
PP
-
EM
IERIEVLRGP
A
A
A
R
YGN
G
A
A
GGVVNIITKKG
S
--------------
GE
W
HG
S
WD
A
YF
N
AP
E
HK
E
E
---
G
----
AT
K
RT
NF
SLT
GPL
-
G
D
EFSF
R
LY
G
NLD
K
TQ
A
D
A
WDINQ
--
GHQSARAGTYA
T
T
L
PAGR
E
GVI
N
K
D
I
N
G
VV
--
R
W
D
F
A
P
L
Q
S
L
EL
E
AGY
SRQ
GNLYA
GDT
Q
NT
N
S
D
A
Y
TR
S
-
-KY
-----------------
G
D
E
T
N
R
L
YR
QNYSLTWNGGWDN
G
V
TTSNWVQ
Y
EH
T
R
---------
N
---------
-
S
R
---
IPE
GL
A
G
GTE
GKFNEKA
A
QDFV
DIDL
D
DVMLH
SE
V
NL
PI
DFLVNQ
T
L
T
L
G
T
EW
NQQ
R
MK
D
LSSNTQA
L
TGTNTG
G
AI
D
G
VSATDRSPYSKA
E
IF
SL
---
-
--
FAE
NNME
LTD
S
T
I
V
T
P
G
L
R
F
--------
DH
------------
HSIV
GN
----------
N
WSP
ALN
I
SQS
L
G
D
D
F
T
LK
M
G
IA
R
A
YKAP
S
L
Y
Q
TNPNYI
L
YSKGQ
G
CYA
--
SA
G
GCY
L
-----
Q
GN
D
DLK
A
E
T
S
I
N
K
EIG
LEF-KRD
G
W
L
A
G
VT
W
F
R
N
D
YR
NKI
E
A
GYVAVGQ
N
A
VGTDLYQ
W
D
N
V
P
KA
V
VE
G
L
E
G
S
LNV
P
-
VSE
T
VMWTN
N
I
T
Y
M
-------
LK
SE
N
KT
---
T
G
D
----
RLS
I
IPEY
T
L
N
S
T
L
S
W
QAR
E
DLSMQTTF
T
WY
GK
QQ
P
KKY
-
NY
KGQP
AV
-----
G
PE
T
KEISP
Y
S
I
VGL
SAT
W
D
V
T
K
---
N
V
S
L
TGG
VDNLFDK
-
-
---R
L
WRA
G
N
AQT
TGDL
AG
ANYIA
G
A
G
A
---
Y
T
Y
NE
PGR
TW
Y
MS
I
N
TH
F
fig|525281.3.peg.2355
Escherichia coli 83972 (47-746/746)
A
P
G
VS
T
I
TA
D
EIR
K
N
-
PVAR
D
V
SE
I
I
R
T
-
M
PGV
N
L
TGN
S
TS
G
QR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
K
P
VSSRNS
VRQG
WR
G
E
R
D
TR
G
----
D
T
SWV
PP
-
EM
IERIEVLRGP
A
A
A
R
YGN
G
A
A
GGVVNIITKKG
S
--------------
GE
W
HG
S
WD
A
YF
N
AP
E
HK
E
E
---
G
----
AT
K
RT
NF
SLT
GPL
-
G
D
EFSF
R
LY
G
NLD
K
TQ
A
D
A
WDINQ
--
GHQSARAGTHA
T
T
L
PAGR
E
GVI
N
K
D
I
N
G
VV
--
R
W
D
F
A
P
L
Q
S
L
EL
E
AGY
SRQ
GNLYA
GDT
Q
NT
N
S
D
A
Y
TR
S
-
-KY
-----------------
G
D
E
T
N
R
L
YR
QNYSLTWNGGWDN
G
V
TTSNWVQ
Y
EH
T
R
---------
N
---------
-
S
R
---
IPE
GL
A
G
GTE
GKFNEKA
A
QDFV
DIDL
D
DVMLH
SE
V
NL
PI
DFLVNQ
T
L
T
L
G
T
EW
NQQ
R
MK
D
LSSNTQA
L
TGTNTG
G
AI
D
G
VSATDRSPYSKA
E
IF
SL
---
-
--
FAE
NNME
LTD
S
T
I
V
T
P
G
L
R
F
--------
DH
------------
HSIV
GN
----------
N
WSP
ALN
I
SQG
L
G
D
D
F
T
LK
M
G
IA
R
A
YKAP
S
L
Y
Q
TNPNYI
L
YSKGQ
G
CYA
--
SA
G
GCY
L
-----
Q
GN
D
DLK
A
E
T
S
I
N
K
EIG
LEF-KRD
G
W
L
A
G
VT
W
F
R
N
D
YR
NKI
E
A
GYVAVGQ
N
A
VGTDLYQ
W
D
N
V
P
KA
V
VE
G
L
E
G
S
LNV
P
-
VSE
T
VMWTN
N
I
T
Y
M
-------
LK
SE
N
KT
---
T
G
D
----
RLS
I
IPEY
T
L
N
S
T
L
S
W
QAR
E
DLSMQTTF
T
WY
GK
QQ
P
KKY
-
NY
KGQP
AV
-----
G
PE
T
KEISP
Y
S
I
VGL
SAT
W
D
V
T
K
---
N
V
S
L
TGG
VDNLFDK
-
-
---R
L
WRA
G
N
AQT
TGDL
AG
ANYIA
G
A
G
A
---
Y
T
Y
NE
PGR
TW
Y
MS
I
N
TH
F
fig|655817.3.peg.676
Escherichia coli ABU 83972 (47-746/746)
A
P
G
VS
T
I
TA
D
EIR
K
N
-
PVAR
D
V
SE
I
I
R
T
-
M
PGV
N
L
TGN
S
TS
G
QR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
K
P
VSSRNS
VRQG
WR
G
E
R
D
TR
G
----
D
T
SWV
PP
-
EM
IERIEVLRGP
A
A
A
R
YGN
G
A
A
GGVVNIITKKG
S
--------------
GE
W
HG
S
WD
A
YF
N
AP
E
HK
E
E
---
G
----
AT
K
RT
NF
SLT
GPL
-
G
D
EFSF
R
LY
G
NLD
K
TQ
A
D
A
WDINQ
--
GHQSARAGTHA
T
T
L
PAGR
E
GVI
N
K
D
I
N
G
VV
--
R
W
D
F
A
P
L
Q
S
L
EL
E
AGY
SRQ
GNLYA
GDT
Q
NT
N
S
D
A
Y
TR
S
-
-KY
-----------------
G
D
E
T
N
R
L
YR
QNYSLTWNGGWDN
G
V
TTSNWVQ
Y
EH
T
R
---------
N
---------
-
S
R
---
IPE
GL
A
G
GTE
GKFNEKA
A
QDFV
DIDL
D
DVMLH
SE
V
NL
PI
DFLVNQ
T
L
T
L
G
T
EW
NQQ
R
MK
D
LSSNTQA
L
TGTNTG
G
AI
D
G
VSATDRSPYSKA
E
IF
SL
---
-
--
FAE
NNME
LTD
S
T
I
V
T
P
G
L
R
F
--------
DH
------------
HSIV
GN
----------
N
WSP
ALN
I
SQG
L
G
D
D
F
T
LK
M
G
IA
R
A
YKAP
S
L
Y
Q
TNPNYI
L
YSKGQ
G
CYA
--
SA
G
GCY
L
-----
Q
GN
D
DLK
A
E
T
S
I
N
K
EIG
LEF-KRD
G
W
L
A
G
VT
W
F
R
N
D
YR
NKI
E
A
GYVAVGQ
N
A
VGTDLYQ
W
D
N
V
P
KA
V
VE
G
L
E
G
S
LNV
P
-
VSE
T
VMWTN
N
I
T
Y
M
-------
LK
SE
N
KT
---
T
G
D
----
RLS
I
IPEY
T
L
N
S
T
L
S
W
QAR
E
DLSMQTTF
T
WY
GK
QQ
P
KKY
-
NY
KGQP
AV
-----
G
PE
T
KEISP
Y
S
I
VGL
SAT
W
D
V
T
K
---
N
V
S
L
TGG
VDNLFDK
-
-
---R
L
WRA
G
N
AQT
TGDL
AG
ANYIA
G
A
G
A
---
Y
T
Y
NE
PGR
TW
Y
MS
I
N
TH
F
fig|550677.3.peg.1003
Escherichia coli B354 (47-746/746)
A
P
G
VS
T
I
TA
D
EIR
K
N
-
PVAR
D
V
SE
I
I
R
T
-
M
PGV
N
L
TGN
S
TS
G
QR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
K
P
VSSRNS
VRQG
WR
G
E
R
D
TR
G
----
D
T
SWV
PP
-
EM
IERIEVLRGP
A
A
A
R
YGN
G
A
A
GGVVNIITKKG
S
--------------
GE
W
HG
S
WD
A
YF
N
AP
E
HK
E
E
---
G
----
AT
K
RT
NF
SLT
GPL
-
G
D
EFSF
R
LY
G
NLD
K
TQ
A
D
A
WDINQ
--
GHQSARAGTYA
T
T
L
PAGR
E
GVI
N
K
D
I
N
G
VV
--
R
W
D
F
A
P
L
Q
S
L
EL
E
AGY
SRQ
GNLYA
GDT
Q
NT
N
S
D
A
Y
TR
S
-
-KY
-----------------
G
D
E
T
N
R
L
YR
QNYSLTWNGGWDN
G
V
TTSNWVQ
Y
EH
T
R
---------
N
---------
-
S
R
---
IPE
GL
A
G
GTE
GKFNEKA
T
QDFV
DIDL
D
DVMLH
SE
V
NL
PI
DFLVNQ
T
L
T
L
G
T
EW
NQQ
R
MK
D
LSSNTQA
L
TGTNTG
G
AI
D
G
VSATDRSPYSKA
E
IF
SL
---
-
--
FAE
NNME
LTD
S
T
I
V
T
P
G
L
R
F
--------
DH
------------
HSIV
GN
----------
N
WSP
ALN
I
SQG
L
G
D
D
F
T
LK
M
G
IA
R
A
YKAP
S
L
Y
Q
TNPNYI
L
YSKGQ
G
CYA
--
SA
G
GCY
L
-----
Q
GN
D
DLK
A
E
T
S
I
N
K
EIG
LEF-KRD
G
W
L
A
G
VT
W
F
R
N
D
YR
NKI
E
A
GYVAVGQ
N
A
VGTDLYQ
W
D
N
V
P
KA
V
VE
G
L
E
G
S
LNV
P
-
VSE
T
VMWTN
N
I
T
Y
M
-------
LK
SE
N
KT
---
T
G
D
----
RLS
I
IPEY
T
L
N
S
T
L
S
W
QAR
E
DLSMQTTF
T
WY
GK
QQ
P
KKY
-
NY
KGQP
AV
-----
G
PE
T
KEISP
Y
S
I
VGL
SAT
W
D
V
T
K
---
N
V
S
L
TGG
VDNLFDK
-
-
---R
L
WRA
G
N
AQT
TGDL
AG
ANYIA
G
A
G
A
---
Y
T
Y
NE
PGR
TW
Y
MS
I
N
TH
F
fig|199310.1.peg.644
Escherichia coli CFT073 (47-746/746)
A
P
G
VS
T
I
TA
D
EIR
K
N
-
PVAR
D
V
SE
I
I
R
T
-
M
PGV
N
L
TGN
S
TS
G
QR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
K
P
VSSRNS
VRQG
WR
G
E
R
D
TR
G
----
D
T
SWV
PP
-
EM
IERIEVLRGP
A
A
A
R
YGN
G
A
A
GGVVNIITKKG
S
--------------
GE
W
HG
S
WD
A
YF
N
AP
E
HK
E
E
---
G
----
AT
K
RT
NF
SLT
GPL
-
G
D
EFSF
R
LY
G
NLD
K
TQ
A
D
A
WDINQ
--
GHQSARAGTYA
T
T
L
PAGR
E
GVI
N
K
D
I
N
G
VV
--
R
W
D
F
A
P
L
Q
S
L
EL
E
AGY
SRQ
GNLYA
GDT
Q
NT
N
S
D
A
Y
TR
S
-
-KY
-----------------
G
D
E
T
N
R
L
YR
QNYSLTWNGGWDN
G
V
TTSNWVQ
Y
EH
T
R
---------
N
---------
-
S
R
---
IPE
GL
A
G
GTE
GKFNEKA
A
QDFV
DIDL
D
DVMLH
SE
V
NL
PI
DFLVNQ
T
L
T
L
G
T
EW
NQQ
R
MK
D
LSSNTQA
L
TGTNTG
G
AI
D
G
VSATDRSPYSKA
E
IF
SL
---
-
--
FAE
NNME
LTD
S
T
I
V
T
P
G
L
R
F
--------
DH
------------
HSIV
GN
----------
N
WSP
ALN
I
SQG
L
G
D
D
F
T
LK
M
G
IA
R
A
YKAP
S
L
Y
Q
TNPNYI
L
YSKGQ
G
CYA
--
SA
G
GCY
L
-----
Q
GN
D
DLK
A
E
T
S
I
N
K
EIG
LEF-KRD
G
W
L
A
G
VT
W
F
R
N
D
YR
NKI
E
A
GYVAVGQ
N
A
VGTDLYQ
W
D
N
V
P
KA
V
VE
G
L
E
G
S
LNV
P
-
VSE
T
VMWTN
N
I
T
Y
M
-------
LK
SE
N
KT
---
T
G
D
----
RLS
I
IPEY
T
L
N
S
T
L
S
W
QAR
E
DLSMQTTF
T
WY
GK
QQ
P
KKY
-
NY
KGQP
AV
-----
G
PE
T
KEISP
Y
S
I
VGL
SAT
W
D
V
T
K
---
N
V
S
L
TGG
VDNLFDK
-
-
---R
L
WRA
G
N
AQT
TGDL
AG
ANYIA
G
A
G
A
---
Y
T
Y
NE
PGR
TW
Y
MS
I
N
TH
F
fig|199310.4.peg.635
Escherichia coli CFT073 (47-746/746)
A
P
G
VS
T
I
TA
D
EIR
K
N
-
PVAR
D
V
SE
I
I
R
T
-
M
PGV
N
L
TGN
S
TS
G
QR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
K
P
VSSRNS
VRQG
WR
G
E
R
D
TR
G
----
D
T
SWV
PP
-
EM
IERIEVLRGP
A
A
A
R
YGN
G
A
A
GGVVNIITKKG
S
--------------
GE
W
HG
S
WD
A
YF
N
AP
E
HK
E
E
---
G
----
AT
K
RT
NF
SLT
GPL
-
G
D
EFSF
R
LY
G
NLD
K
TQ
A
D
A
WDINQ
--
GHQSARAGTYA
T
T
L
PAGR
E
GVI
N
K
D
I
N
G
VV
--
R
W
D
F
A
P
L
Q
S
L
EL
E
AGY
SRQ
GNLYA
GDT
Q
NT
N
S
D
A
Y
TR
S
-
-KY
-----------------
G
D
E
T
N
R
L
YR
QNYSLTWNGGWDN
G
V
TTSNWVQ
Y
EH
T
R
---------
N
---------
-
S
R
---
IPE
GL
A
G
GTE
GKFNEKA
A
QDFV
DIDL
D
DVMLH
SE
V
NL
PI
DFLVNQ
T
L
T
L
G
T
EW
NQQ
R
MK
D
LSSNTQA
L
TGTNTG
G
AI
D
G
VSATDRSPYSKA
E
IF
SL
---
-
--
FAE
NNME
LTD
S
T
I
V
T
P
G
L
R
F
--------
DH
------------
HSIV
GN
----------
N
WSP
ALN
I
SQG
L
G
D
D
F
T
LK
M
G
IA
R
A
YKAP
S
L
Y
Q
TNPNYI
L
YSKGQ
G
CYA
--
SA
G
GCY
L
-----
Q
GN
D
DLK
A
E
T
S
I
N
K
EIG
LEF-KRD
G
W
L
A
G
VT
W
F
R
N
D
YR
NKI
E
A
GYVAVGQ
N
A
VGTDLYQ
W
D
N
V
P
KA
V
VE
G
L
E
G
S
LNV
P
-
VSE
T
VMWTN
N
I
T
Y
M
-------
LK
SE
N
KT
---
T
G
D
----
RLS
I
IPEY
T
L
N
S
T
L
S
W
QAR
E
DLSMQTTF
T
WY
GK
QQ
P
KKY
-
NY
KGQP
AV
-----
G
PE
T
KEISP
Y
S
I
VGL
SAT
W
D
V
T
K
---
N
V
S
L
TGG
VDNLFDK
-
-
---R
L
WRA
G
N
AQT
TGDL
AG
ANYIA
G
A
G
A
---
Y
T
Y
NE
PGR
TW
Y
MS
I
N
TH
F
fig|216593.1.peg.3037
Escherichia coli E2348/69 (47-746/746)
A
P
G
VS
T
I
TA
D
EIR
K
N
-
PVAR
D
V
SE
I
I
R
T
-
M
PGV
N
L
TGN
S
TS
G
QR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
K
P
VSSRNS
VRQG
WR
G
E
R
D
TR
G
----
D
T
SWV
PP
-
EM
IERIEVLRGP
A
A
A
R
YGN
G
A
A
GGVVNIITKKG
S
--------------
GE
W
HG
S
WD
A
YF
N
AP
E
HK
E
E
---
G
----
AT
K
RT
NF
SLT
GPL
-
G
D
EFSF
R
LY
G
NLD
K
TQ
A
D
A
WDINQ
--
GHQSARAGTYA
T
T
L
PAGR
E
GVI
N
K
D
I
N
G
VV
--
R
W
D
F
A
P
L
Q
S
L
EL
E
AGY
SRQ
GNLYA
GDT
Q
NT
N
S
D
A
Y
TR
S
-
-KY
-----------------
G
D
E
T
N
R
L
YR
QNYSLTWNGGWDN
G
V
TTSNWVQ
Y
EH
T
R
---------
N
---------
-
S
R
---
IPE
GL
A
G
GTE
GKFNEKA
A
QDFV
DIDL
D
DVMLH
SE
V
NL
PI
DFLVNQ
T
L
T
L
G
T
EW
NQQ
R
MK
D
LSSNTQA
L
TGTNTG
G
AI
D
G
VSATDRSPYSKA
E
IF
SL
---
-
--
FAE
NNME
LTD
S
T
I
V
T
P
G
L
R
F
--------
DH
------------
HSIV
GN
----------
N
WSP
ALN
I
SQG
L
G
D
D
F
T
LK
M
G
IA
R
A
YKAP
S
L
Y
Q
TNPNYI
L
YSKGQ
G
CYA
--
SA
G
GCY
L
-----
Q
GN
D
DLK
A
E
T
S
I
N
K
EIG
LEF-KRD
G
W
L
A
G
VT
W
F
R
N
D
YR
NKI
E
A
GYVAVGQ
N
A
VGTDLYQ
W
D
N
V
P
KA
V
VE
G
L
E
G
S
LNV
P
-
VSE
T
VMWTN
N
I
T
Y
M
-------
LK
SE
N
KT
---
T
G
D
----
RLS
I
IPEY
T
L
N
S
T
L
S
W
QAR
E
DLSMQTTF
T
WY
GK
QQ
P
KKY
-
NY
KGQP
AV
-----
G
PE
T
KEISP
Y
S
I
VGL
SAT
W
D
V
T
K
---
N
V
S
L
TGG
VDNLFDK
-
-
---R
L
WRA
G
N
AQT
TGDL
AG
ANYIA
G
A
G
A
---
Y
T
Y
NE
PGR
TW
Y
MS
I
N
TH
F
fig|714962.3.peg.610
Escherichia coli IHE3034 (47-746/746)
A
P
G
VS
T
I
TA
D
EIR
K
N
-
PVAR
D
V
SE
I
I
R
T
-
M
PGV
N
L
TGN
S
TS
G
QR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
K
P
VSSRNS
VRQG
WR
G
E
R
D
TR
G
----
D
T
SWV
PP
-
EM
IERIEVLRGP
A
A
A
R
YGN
G
A
A
GGVVNIITKKG
S
--------------
GE
W
HG
S
WD
A
YF
N
AP
E
HK
E
E
---
G
----
AT
K
RT
NF
SLT
GPL
-
G
D
EFSF
R
LY
G
NLD
K
TQ
A
D
A
WDINQ
--
GHQSARAGTYA
T
T
L
PAGR
E
GVI
N
K
D
I
N
G
VV
--
R
W
D
F
A
P
L
Q
S
L
EL
E
AGY
SRQ
GNLYA
GDT
Q
NT
N
S
D
A
Y
TR
S
-
-KY
-----------------
G
D
E
T
N
R
L
YR
QNYSLTWNGGWDN
G
V
TTSNWVQ
Y
EH
T
R
---------
N
---------
-
S
R
---
IPE
GL
A
G
GTE
GKFNEKA
A
QDFV
DIDL
D
DVMLH
SE
V
NL
PI
DFLVNQ
T
L
T
L
G
T
EW
NQQ
R
MK
D
LSSNTQA
L
TGTNTG
G
AI
D
G
VSATDRSPYSKA
E
IF
SL
---
-
--
FAE
NNME
LTD
S
T
I
V
T
P
G
L
R
F
--------
DH
------------
HSIV
GN
----------
N
WSP
ALN
I
SQG
L
G
D
D
F
T
LK
M
G
IA
R
A
YKAP
S
L
Y
Q
TNPNYI
L
YSKGQ
G
CYA
--
SA
G
GCY
L
-----
Q
GN
D
DLK
A
E
T
S
I
N
K
EIG
LEF-KRD
G
W
L
A
G
VT
W
F
R
N
D
YR
NKI
E
A
GYVAVGQ
N
A
VGTDLYQ
W
D
N
V
P
KA
V
VE
G
L
E
G
S
LNV
P
-
VSE
T
VMWTN
N
I
T
Y
M
-------
LK
SE
N
KT
---
T
G
D
----
RLS
I
IPEY
T
L
N
S
T
L
S
W
QAR
E
DLSMQTTF
T
WY
GK
QQ
P
KKY
-
NY
KGQP
AV
-----
G
PE
T
KEISP
Y
S
I
VGL
SAT
W
D
V
T
K
---
N
V
S
L
TGG
VDNLFDK
-
-
---R
L
WRA
G
N
AQT
TGDL
AG
ANYIA
G
A
G
A
---
Y
T
Y
NE
PGR
TW
Y
MS
I
N
TH
F
fig|656417.3.peg.705
Escherichia coli M605 (47-746/746)
A
P
G
VS
T
I
TA
D
EIR
K
N
-
PVAR
D
V
SE
I
I
R
T
-
M
PGV
N
L
TGN
S
TS
G
QR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
K
P
VSSRNS
VRQG
WR
G
E
R
D
TR
G
----
D
T
SWV
PP
-
EM
IERIEVLRGP
A
A
A
R
YGN
G
A
A
GGVVNIITKKG
S
--------------
GE
W
HG
S
WD
A
YF
N
AP
E
HK
E
E
---
G
----
AT
K
RT
NF
SLT
GPL
-
G
D
EFSF
R
LY
G
NLD
K
TQ
A
D
A
WDINQ
--
GHQSARAGTYA
T
T
L
PAGR
E
GVI
N
K
D
I
N
G
VV
--
R
W
D
F
A
P
L
Q
S
L
EL
E
AGY
SRQ
GNLYA
GDT
Q
NT
N
S
D
A
Y
TR
S
-
-KY
-----------------
G
D
E
T
N
R
L
YR
QNYSLTWNGGWDN
G
V
TTSNWVQ
Y
EH
T
R
---------
N
---------
-
S
R
---
IPE
GL
A
G
GTE
GKFNEKA
A
QDFV
DIDL
D
DVMLH
SE
V
NL
PI
DFLVNQ
T
L
T
L
G
T
EW
NQQ
R
MK
D
LSSNTQA
L
TGTNTG
G
AI
D
G
VSATDRSPYSKA
E
IF
SL
---
-
--
FAE
NNME
LTD
S
T
I
V
T
P
G
L
R
F
--------
DH
------------
HSIV
GN
----------
N
WSP
ALN
I
SQG
L
G
D
D
F
T
LK
M
G
IA
R
A
YKAP
S
L
Y
Q
TNPNYI
L
YSKGQ
G
CYA
--
SA
G
GCY
L
-----
Q
GN
D
DLK
A
E
T
S
I
N
K
EIG
LEF-KRD
G
W
L
A
G
VT
W
F
R
N
D
YR
NKI
E
A
GYVAVG
K
N
A
VGTDLYQ
W
D
N
V
P
KA
V
VE
G
L
E
G
S
LNV
P
-
VSE
T
VMWTN
N
I
T
Y
M
-------
LK
SE
N
KT
---
T
G
D
----
RLS
I
IPEY
T
L
N
S
T
L
S
W
QAR
E
DLSMQTTF
T
WY
GK
QQ
P
KKY
-
NY
KGQP
AV
-----
G
PE
T
KEISP
Y
S
I
VGL
SAT
W
D
V
T
K
---
N
V
S
L
TGG
VDNLFDK
-
-
---R
L
WRA
G
N
AQT
TGDL
AG
ANYIA
G
A
G
A
---
Y
T
Y
NE
PGR
TW
Y
MS
I
N
TH
F
fig|749528.3.peg.4054
Escherichia coli MS 45-1 (47-746/746)
A
P
G
VS
T
I
TA
D
EIR
K
N
-
PVAR
D
V
SE
I
I
R
T
-
M
PGV
N
L
TGN
S
TS
G
QR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
K
P
VSSRNS
VRQG
WR
G
E
R
D
TR
G
----
D
T
SWV
PP
-
EM
IERIEVLRGP
A
A
A
R
YGN
G
A
A
GGVVNIITKKG
S
--------------
GE
W
HG
S
WD
A
YF
N
AP
E
HK
E
E
---
G
----
AT
K
RT
NF
SLT
GPL
-
G
D
EFSF
R
LY
G
NLD
K
TQ
A
D
A
WDINQ
--
GHQSARAGTYA
T
T
L
PAGR
E
GVI
N
K
D
I
N
G
VV
--
R
W
D
F
A
P
L
Q
S
L
EL
E
AGY
SRQ
GNLYA
GDT
Q
NT
N
S
D
A
Y
TR
S
-
-KY
-----------------
G
D
E
T
N
R
L
YR
QNYSLTWNGGWDN
G
V
TTSNWVQ
Y
EH
T
R
---------
N
---------
-
S
R
---
IPE
GL
A
G
GTE
GKFNEKA
A
QDFV
DIDL
D
DVMLH
SE
V
NL
PI
DFLVNQ
T
L
T
L
G
T
EW
NQQ
R
MK
D
LSSNTQA
L
TGTNTG
G
AI
D
G
VSATDRSPYSKA
E
IF
SL
---
-
--
FAE
NNME
LTD
S
T
I
V
T
P
G
L
R
F
--------
DH
------------
HSIV
GN
----------
N
WSP
ALN
I
SQG
L
G
D
D
F
T
LK
M
G
IA
R
A
YKAP
S
L
Y
Q
TNPNYI
L
YSKGQ
G
CYA
--
SA
G
GCY
L
-----
Q
GN
D
DLK
A
E
T
S
I
N
K
EIG
LEF-KRD
G
W
L
A
G
VT
W
F
R
N
D
YR
NKI
E
A
GYVAVGQ
N
A
VGTDLYQ
W
D
N
V
P
KA
V
VE
G
L
E
G
S
LNV
P
-
VSE
T
VMWTN
N
I
T
Y
M
-------
LK
SE
N
KT
---
T
G
D
----
RLS
I
IPEY
T
L
N
S
T
L
S
W
QAR
E
DLSMQTTF
T
WY
GK
QQ
P
KKY
-
NY
KGQP
AV
-----
G
PE
T
KEISP
Y
S
I
VGL
SAT
W
D
V
T
K
---
N
V
S
L
TGG
VDNLFDK
-
-
---R
L
WRA
G
N
AQT
TGDL
AG
ANYIA
G
A
G
A
---
Y
T
Y
NE
PGR
TW
Y
MS
I
N
TH
F
fig|574521.7.peg.521
Escherichia coli O127:H6 str. E2348/69 (47-746/746)
A
P
G
VS
T
I
TA
D
EIR
K
N
-
PVAR
D
V
SE
I
I
R
T
-
M
PGV
N
L
TGN
S
TS
G
QR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
K
P
VSSRNS
VRQG
WR
G
E
R
D
TR
G
----
D
T
SWV
PP
-
EM
IERIEVLRGP
A
A
A
R
YGN
G
A
A
GGVVNIITKKG
S
--------------
GE
W
HG
S
WD
A
YF
N
AP
E
HK
E
E
---
G
----
AT
K
RT
NF
SLT
GPL
-
G
D
EFSF
R
LY
G
NLD
K
TQ
A
D
A
WDINQ
--
GHQSARAGTYA
T
T
L
PAGR
E
GVI
N
K
D
I
N
G
VV
--
R
W
D
F
A
P
L
Q
S
L
EL
E
AGY
SRQ
GNLYA
GDT
Q
NT
N
S
D
A
Y
TR
S
-
-KY
-----------------
G
D
E
T
N
R
L
YR
QNYSLTWNGGWDN
G
V
TTSNWVQ
Y
EH
T
R
---------
N
---------
-
S
R
---
IPE
GL
A
G
GTE
GKFNEKA
A
QDFV
DIDL
D
DVMLH
SE
V
NL
PI
DFLVNQ
T
L
T
L
G
T
EW
NQQ
R
MK
D
LSSNTQA
L
TGTNTG
G
AI
D
G
VSATDRSPYSKA
E
IF
SL
---
-
--
FAE
NNME
LTD
S
T
I
V
T
P
G
L
R
F
--------
DH
------------
HSIV
GN
----------
N
WSP
ALN
I
SQG
L
G
D
D
F
T
LK
M
G
IA
R
A
YKAP
S
L
Y
Q
TNPNYI
L
YSKGQ
G
CYA
--
SA
G
GCY
L
-----
Q
GN
D
DLK
A
E
T
S
I
N
K
EIG
LEF-KRD
G
W
L
A
G
VT
W
F
R
N
D
YR
NKI
E
A
GYVAVGQ
N
A
VGTDLYQ
W
D
N
V
P
KA
V
VE
G
L
E
G
S
LNV
P
-
VSE
T
VMWTN
N
I
T
Y
M
-------
LK
SE
N
KT
---
T
G
D
----
RLS
I
IPEY
T
L
N
S
T
L
S
W
QAR
E
DLSMQTTF
T
WY
GK
QQ
P
KKY
-
NY
KGQP
AV
-----
G
PE
T
KEISP
Y
S
I
VGL
SAT
W
D
V
T
K
---
N
V
S
L
TGG
VDNLFDK
-
-
---R
L
WRA
G
N
AQT
TGDL
AG
ANYIA
G
A
G
A
---
Y
T
Y
NE
PGR
TW
Y
MS
I
N
TH
F
fig|431946.3.peg.543
Escherichia coli SE15 (47-746/746)
A
P
G
VS
T
I
TA
D
EIR
K
N
-
PVAR
D
V
SE
I
I
R
T
-
M
PGV
N
L
TGN
S
TS
G
QR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
K
P
VSSRNS
VRQG
WR
G
E
R
D
TR
G
----
D
T
SWV
PP
-
EM
IERIEVLRGP
A
A
A
R
YGN
G
A
A
GGVVNIITKKG
S
--------------
GE
W
HG
S
WD
A
YF
N
AP
E
HK
E
E
---
G
----
AT
K
RT
NF
SLT
GPL
-
G
D
EFSF
R
LY
G
NLD
K
TQ
A
D
A
WDINQ
--
GHQSARAGTYA
T
T
L
PAGR
E
GVI
N
K
D
I
N
G
VV
--
R
W
D
F
A
P
L
Q
S
L
EL
E
AGY
SRQ
GNLYA
GDT
Q
NT
N
S
D
A
Y
TR
S
-
-KY
-----------------
G
D
E
T
N
R
L
YR
QNYSLTWNGGWDN
G
V
TTSNWVQ
Y
EH
T
R
---------
N
---------
-
S
R
---
IPE
GL
A
G
GTE
GKFNEKA
A
QDFV
DIDL
D
DVMLH
SE
V
NL
PI
DFLVNQ
T
L
T
L
G
T
EW
NQQ
R
MK
D
LSSNTQA
L
TGTNTG
G
AI
D
G
VSATDRSPYSKA
E
IF
SL
---
-
--
FAE
NNME
LTD
S
T
I
V
T
P
G
L
R
F
--------
DH
------------
HSIV
GN
----------
N
WSP
ALN
I
SQG
L
G
D
D
F
T
LK
M
G
IA
R
A
YKAP
S
L
Y
Q
TNPNYI
L
YSKGQ
G
CYA
--
SA
G
GCY
L
-----
Q
GN
D
DLK
A
E
T
S
I
N
K
EIG
LEF-KRD
G
W
L
A
G
VT
W
F
R
N
D
YR
NKI
E
A
GYVAVG
K
N
A
VGTDLYQ
W
D
N
V
P
KA
V
VE
G
L
E
G
S
LNV
P
-
VSE
T
VMWTN
N
I
T
Y
M
-------
LK
SE
N
KT
---
T
G
D
----
RLS
I
IPEY
T
L
N
S
T
L
S
W
QAR
E
DLSMQTTF
T
WY
GK
QQ
P
KKY
-
NY
KGQP
AV
-----
G
PE
T
KEISP
Y
S
I
VGL
SAT
W
D
V
T
K
---
N
V
S
L
TGG
VDNLFDK
-
-
---R
L
WRA
G
N
AQT
TGDL
AG
ANYIA
G
A
G
A
---
Y
T
Y
NE
PGR
TW
Y
MS
I
N
TH
F
fig|656440.3.peg.439
Escherichia coli TA206 (47-746/746)
A
P
G
VS
T
I
TA
D
EIR
K
N
-
PVAR
D
V
SE
I
I
R
T
-
M
PGV
N
L
TGN
S
TS
G
QR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
K
P
VSSRNS
VRQG
WR
G
E
R
D
TR
G
----
D
T
SWV
PP
-
EM
IERIEVLRGP
A
A
A
R
YGN
G
A
A
GGVVNIITKKG
S
--------------
GE
W
HG
S
WD
A
YF
N
AP
E
HK
E
E
---
G
----
AT
K
RT
NF
SLT
GPL
-
G
D
EFSF
R
LY
G
NLD
K
TQ
A
D
A
WDINQ
--
GHQSARAGTYA
T
T
L
PAGR
E
GVI
N
K
D
I
N
G
VV
--
R
W
D
F
A
P
L
Q
S
L
EL
E
AGY
SRQ
GNLYA
GDT
Q
NT
N
S
D
A
Y
TR
S
-
-KY
-----------------
G
D
E
T
N
R
L
YR
QNYSLTWNGGWDN
G
V
TTSNWVQ
Y
EH
T
R
---------
N
---------
-
S
R
---
IPE
GL
A
G
GTE
GKFNEKA
A
QDFV
DIDL
D
DVMLH
SE
V
NL
PI
DFLVNQ
T
L
T
L
G
T
EW
NQQ
R
MK
D
LSSNTQA
L
TGTNTG
G
AI
D
G
VSATDRSPYSKA
E
IF
SL
---
-
--
FAE
NNME
LTD
S
T
I
V
T
P
G
L
R
F
--------
DH
------------
HSIV
GN
----------
N
WSP
ALN
I
SQG
L
G
D
D
F
T
LK
M
G
IA
R
A
YKAP
S
L
Y
Q
TNPNYI
L
YSKGQ
G
CYA
--
SA
G
GCY
L
-----
Q
GN
D
DLK
A
E
T
S
I
N
K
EIG
LEF-KRD
G
W
L
A
G
VT
W
F
R
N
D
YR
NKI
E
A
GYVAVGQ
N
A
VGTDLYQ
W
D
N
V
P
KA
V
VE
G
L
E
G
S
LNV
P
-
VSE
T
VMWTN
N
I
T
Y
M
-------
LK
SE
N
KT
---
T
G
D
----
RLS
I
IPEY
T
L
N
S
T
L
S
W
QAR
E
DLSMQTTF
T
WY
GK
QQ
P
KKY
-
NY
KGQP
AV
-----
G
PE
T
KEISP
Y
S
I
VGL
SAT
W
D
V
T
K
---
N
V
S
L
TGG
VDNLFDK
-
-
---R
L
WRA
G
N
AQT
TGDL
AG
ANYIA
G
A
G
A
---
Y
T
Y
NE
PGR
TW
Y
MS
I
N
TH
F
fig|869729.3.peg.3122
Escherichia coli UM146 (47-746/746)
A
P
G
VS
T
I
TA
D
EIR
K
N
-
PVAR
D
V
SE
I
I
R
T
-
M
PGV
N
L
TGN
S
TS
G
QR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
K
P
VSSRNS
VRQG
WR
G
E
R
D
TR
G
----
D
T
SWV
PP
-
EM
IERIEVLRGP
A
A
A
R
YGN
G
A
A
GGVVNIITKKG
S
--------------
GE
W
HG
S
WD
A
YF
N
AP
E
HK
E
E
---
G
----
AT
K
RT
NF
SLT
GPL
-
G
D
EFSF
R
LY
G
NLD
K
TQ
A
D
A
WDINQ
--
GHQSARAGTYA
T
T
L
PAGR
E
GVI
N
K
D
I
N
G
VV
--
R
W
D
F
A
P
L
Q
S
L
EL
E
AGY
SRQ
GNLYA
GDT
Q
NT
N
S
D
A
Y
TR
S
-
-KY
-----------------
G
D
E
T
N
R
L
YR
QNYSLTWNGGWDN
G
V
TTSNWVQ
Y
EH
T
R
---------
N
---------
-
S
R
---
IPE
GL
A
G
GTE
GKFNEKA
A
QDFV
DIDL
D
DVMLH
SE
V
NL
PI
DFLVNQ
T
L
T
L
G
T
EW
NQQ
R
MK
D
LSSNTQA
L
TGTNTG
G
AI
D
G
VSATDRSPYSKA
E
IF
SL
---
-
--
FAE
NNME
LTD
S
T
I
V
T
P
G
L
R
F
--------
DH
------------
HSIV
GN
----------
N
WSP
ALN
I
SQG
L
G
D
D
F
T
LK
M
G
IA
R
A
YKAP
S
L
Y
Q
TNPNYI
L
YSKGQ
G
CYA
--
SA
G
GCY
L
-----
Q
GN
D
DLK
A
E
T
S
I
N
K
EIG
LEF-KRD
G
W
L
A
G
VT
W
F
R
N
D
YR
NKI
E
A
GYVAVGQ
N
A
VGTDLYQ
W
D
N
V
P
KA
V
VE
G
L
E
G
S
LNV
P
-
VSE
T
VMWTN
N
I
T
Y
M
-------
LK
SE
N
KT
---
T
G
D
----
RLS
I
IPEY
T
L
N
S
T
L
S
W
QAR
E
DLSMQTTF
T
WY
GK
QQ
P
KKY
-
NY
KGQP
AV
-----
G
PE
T
KEISP
Y
S
I
VGL
SAT
W
D
V
T
K
---
N
V
S
L
TGG
VDNLFDK
-
-
---R
L
WRA
G
N
AQT
TGDL
AG
ANYIA
G
A
G
A
---
Y
T
Y
NE
PGR
TW
Y
MS
I
N
TH
F
fig|364106.7.peg.690
Escherichia coli UTI89 (47-746/746)
A
P
G
VS
T
I
TA
D
EIR
K
N
-
PVAR
D
V
SE
I
I
R
T
-
M
PGV
N
L
TGN
S
TS
G
QR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
K
P
VSSRNS
VRQG
WR
G
E
R
D
TR
G
----
D
T
SWV
PP
-
EM
IERIEVLRGP
A
A
A
R
YGN
G
A
A
GGVVNIITKKG
S
--------------
GE
W
HG
S
WD
A
YF
N
AP
E
HK
E
E
---
G
----
AT
K
RT
NF
SLT
GPL
-
G
D
EFSF
R
LY
G
NLD
K
TQ
A
D
A
WDINQ
--
GHQSARAGTYA
T
T
L
PAGR
E
GVI
N
K
D
I
N
G
VV
--
R
W
D
F
A
P
L
Q
S
L
EL
E
AGY
SRQ
GNLYA
GDT
Q
NT
N
S
D
A
Y
TR
S
-
-KY
-----------------
G
D
E
T
N
R
L
YR
QNYSLTWNGGWDN
G
V
TTSNWVQ
Y
EH
T
R
---------
N
---------
-
S
R
---
IPE
GL
A
G
GTE
GKFNEKA
A
QDFV
DIDL
D
DVMLH
SE
V
NL
PI
DFLVNQ
T
L
T
L
G
T
EW
NQQ
R
MK
D
LSSNTQA
L
TGTNTG
G
AI
D
G
VSATDRSPYSKA
E
IF
SL
---
-
--
FAE
NNME
LTD
S
T
I
V
T
P
G
L
R
F
--------
DH
------------
HSIV
GN
----------
N
WSP
ALN
I
SQG
L
G
D
D
F
T
LK
M
G
IA
R
A
YKAP
S
L
Y
Q
TNPNYI
L
YSKGQ
G
CYA
--
SA
G
GCY
L
-----
Q
GN
D
DLK
A
E
T
S
I
N
K
EIG
LEF-KRD
G
W
L
A
G
VT
W
F
R
N
D
YR
NKI
E
A
GYVAVGQ
N
A
VGTDLYQ
W
D
N
V
P
KA
V
VE
G
L
E
G
S
LNV
P
-
VSE
T
VMWTN
N
I
T
Y
M
-------
LK
SE
N
KT
---
T
G
D
----
RLS
I
IPEY
T
L
N
S
T
L
S
W
QAR
E
DLSMQTTF
T
WY
GK
QQ
P
KKY
-
NY
KGQP
AV
-----
G
PE
T
KEISP
Y
S
I
VGL
SAT
W
D
V
T
K
---
N
V
S
L
TGG
VDNLFDK
-
-
---R
L
WRA
G
N
AQT
TGDL
AG
ANYIA
G
A
G
A
---
Y
T
Y
NE
PGR
TW
Y
MS
I
N
TH
F
fig|364106.8.peg.688
Escherichia coli UTI89 (47-746/746)
A
P
G
VS
T
I
TA
D
EIR
K
N
-
PVAR
D
V
SE
I
I
R
T
-
M
PGV
N
L
TGN
S
TS
G
QR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
K
P
VSSRNS
VRQG
WR
G
E
R
D
TR
G
----
D
T
SWV
PP
-
EM
IERIEVLRGP
A
A
A
R
YGN
G
A
A
GGVVNIITKKG
S
--------------
GE
W
HG
S
WD
A
YF
N
AP
E
HK
E
E
---
G
----
AT
K
RT
NF
SLT
GPL
-
G
D
EFSF
R
LY
G
NLD
K
TQ
A
D
A
WDINQ
--
GHQSARAGTYA
T
T
L
PAGR
E
GVI
N
K
D
I
N
G
VV
--
R
W
D
F
A
P
L
Q
S
L
EL
E
AGY
SRQ
GNLYA
GDT
Q
NT
N
S
D
A
Y
TR
S
-
-KY
-----------------
G
D
E
T
N
R
L
YR
QNYSLTWNGGWDN
G
V
TTSNWVQ
Y
EH
T
R
---------
N
---------
-
S
R
---
IPE
GL
A
G
GTE
GKFNEKA
A
QDFV
DIDL
D
DVMLH
SE
V
NL
PI
DFLVNQ
T
L
T
L
G
T
EW
NQQ
R
MK
D
LSSNTQA
L
TGTNTG
G
AI
D
G
VSATDRSPYSKA
E
IF
SL
---
-
--
FAE
NNME
LTD
S
T
I
V
T
P
G
L
R
F
--------
DH
------------
HSIV
GN
----------
N
WSP
ALN
I
SQG
L
G
D
D
F
T
LK
M
G
IA
R
A
YKAP
S
L
Y
Q
TNPNYI
L
YSKGQ
G
CYA
--
SA
G
GCY
L
-----
Q
GN
D
DLK
A
E
T
S
I
N
K
EIG
LEF-KRD
G
W
L
A
G
VT
W
F
R
N
D
YR
NKI
E
A
GYVAVGQ
N
A
VGTDLYQ
W
D
N
V
P
KA
V
VE
G
L
E
G
S
LNV
P
-
VSE
T
VMWTN
N
I
T
Y
M
-------
LK
SE
N
KT
---
T
G
D
----
RLS
I
IPEY
T
L
N
S
T
L
S
W
QAR
E
DLSMQTTF
T
WY
GK
QQ
P
KKY
-
NY
KGQP
AV
-----
G
PE
T
KEISP
Y
S
I
VGL
SAT
W
D
V
T
K
---
N
V
S
L
TGG
VDNLFDK
-
-
---R
L
WRA
G
N
AQT
TGDL
AG
ANYIA
G
A
G
A
---
Y
T
Y
NE
PGR
TW
Y
MS
I
N
TH
F
fig|562.376.peg.2032
Escherichia coli WV_060327 (47-746/746)
A
P
G
VS
T
I
TA
D
EIR
K
N
-
PVAR
D
V
SE
I
I
R
T
-
M
PGV
N
L
TGN
S
TS
G
QR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
K
P
VSSRNS
VRQG
WR
G
E
R
D
TR
G
----
D
T
SWV
PP
-
EM
IERIEVLRGP
A
A
A
R
YGN
G
A
A
GGVVNIITKKG
S
--------------
GE
W
HG
S
WD
A
YF
N
AP
E
HK
E
E
---
G
----
AT
K
RT
NF
SLT
GPL
-
G
D
EFSF
R
LY
G
NLD
K
TQ
A
D
A
WDINQ
--
GHQSARAGTYA
T
T
L
PAGR
E
GVI
N
K
D
I
N
G
VV
--
R
W
D
F
A
P
L
Q
S
L
EL
E
AGY
SRQ
GNLYA
GDT
Q
NT
N
S
D
A
Y
TR
S
-
-KY
-----------------
G
D
E
T
N
R
L
YR
QNYSLTWNGGWDN
G
V
TTSNWVQ
Y
EH
T
R
---------
N
---------
-
S
R
---
IPE
GL
A
G
GTE
GKFNEKA
A
QDFV
DIDL
D
DVMLH
SE
V
NL
PI
DFLVNQ
T
L
T
L
G
T
EW
NQQ
R
MK
D
LSSNTQA
L
TGTNTG
G
AI
D
G
VSATDRSPYSKA
E
IF
SL
---
-
--
FAE
NNME
LTD
S
T
I
V
T
P
G
L
R
F
--------
DH
------------
HSIV
GN
----------
N
WSP
ALN
I
SQG
L
G
D
D
F
T
LK
M
G
IA
R
A
YKAP
S
L
Y
Q
TNPNYI
L
YSKGQ
G
CYA
--
SA
G
GCY
L
-----
Q
GN
D
DLK
A
E
T
S
I
N
K
EIG
LEF-KRD
G
W
L
A
G
VT
W
F
R
N
D
YR
NKI
E
A
GYVAVGQ
N
A
VGTDLYQ
W
D
N
V
P
KA
V
VE
G
L
E
G
S
LNV
P
-
VSE
T
VMWTN
N
I
T
Y
M
-------
LK
SE
N
KT
---
T
G
D
----
RLS
I
IPEY
T
L
N
S
T
L
S
W
QAR
E
DLSMQTTF
T
WY
GK
QQ
P
KKY
-
NY
KGQP
AV
-----
G
PE
T
KEISP
Y
S
I
VGL
SAT
W
D
V
T
K
---
N
V
S
L
TGG
VDNLFDK
-
-
---R
L
WRA
G
N
AQT
TGDL
AG
ANYIA
G
A
G
A
---
Y
T
Y
NE
PGR
TW
Y
MS
I
N
TH
F
fig|216592.1.peg.338
Escherichia coli 042 (47-746/746)
A
P
G
VS
T
I
TA
D
EIR
K
N
-
PVAR
D
V
SE
I
I
R
T
-
M
PGV
N
L
TGN
S
TS
G
QR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
K
P
VSSRNS
VRQG
WR
G
E
R
D
TR
G
----
D
T
SWV
PP
-
EM
IERIEVLRGP
A
A
A
R
YGN
G
A
A
GGVVNIITKKG
S
--------------
GE
W
HG
S
WD
A
YF
N
AP
E
HK
E
E
---
G
----
AT
K
RT
NF
SLT
GPL
-
G
D
EFSF
R
LY
G
NLD
K
TQ
A
D
A
WDINQ
--
GHQSARAGTYA
T
T
L
PAGR
E
GVI
N
K
D
I
N
G
VV
--
R
W
D
F
A
P
L
Q
S
L
EL
E
AGY
SRQ
GNLYA
GDT
Q
NT
N
S
D
S
Y
TR
S
-
-KY
-----------------
G
D
E
T
N
R
L
YR
QNYSLTWNGGWDN
G
V
TTSNWVQ
Y
EH
T
R
---------
N
---------
-
S
R
---
IPE
GL
A
G
GTE
GKFNEKA
T
QDFV
DIDL
D
DVMLH
SE
V
NL
PI
DFLVNQ
T
L
T
L
G
T
EW
NQQ
R
MK
D
LSSNTQA
L
TGTNTG
G
AI
D
G
VSATDRSPYSKA
E
IF
SL
---
-
--
FAE
NNME
LTD
S
T
I
V
T
P
G
L
R
F
--------
DH
------------
HSIV
GN
----------
N
WSP
ALN
I
SQG
L
G
D
D
F
T
LK
M
G
IA
R
A
YKAP
S
L
Y
Q
TNPNYI
L
YSKGQ
G
CYA
--
SA
G
GCY
L
-----
Q
GN
D
DLK
A
E
T
S
I
N
K
EIG
LEF-KRD
G
W
L
A
G
VT
W
F
R
N
D
YR
NKI
E
A
GYVAVGQ
N
A
VGTDLYQ
W
D
N
V
P
KA
V
VE
G
L
E
G
S
LNV
P
-
VSE
T
VMWTN
N
I
T
Y
M
-------
LK
SE
N
KT
---
T
G
D
----
RLS
I
IPEY
T
L
N
S
T
L
S
W
QAR
E
DLSMQTTF
T
WY
GK
QQ
P
KKY
-
NY
KGQP
AV
-----
G
PE
T
KEISP
Y
S
I
VGL
SAT
W
D
V
T
K
---
N
V
S
L
TGG
VDNLFDK
-
-
---R
L
WRA
G
N
AQT
TGDL
AG
ANYIA
G
A
G
A
---
Y
T
Y
NE
PGR
TW
Y
MS
I
N
TH
F
fig|216592.3.peg.646
Escherichia coli 042 (47-746/746)
A
P
G
VS
T
I
TA
D
EIR
K
N
-
PVAR
D
V
SE
I
I
R
T
-
M
PGV
N
L
TGN
S
TS
G
QR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
K
P
VSSRNS
VRQG
WR
G
E
R
D
TR
G
----
D
T
SWV
PP
-
EM
IERIEVLRGP
A
A
A
R
YGN
G
A
A
GGVVNIITKKG
S
--------------
GE
W
HG
S
WD
A
YF
N
AP
E
HK
E
E
---
G
----
AT
K
RT
NF
SLT
GPL
-
G
D
EFSF
R
LY
G
NLD
K
TQ
A
D
A
WDINQ
--
GHQSARAGTYA
T
T
L
PAGR
E
GVI
N
K
D
I
N
G
VV
--
R
W
D
F
A
P
L
Q
S
L
EL
E
AGY
SRQ
GNLYA
GDT
Q
NT
N
S
D
S
Y
TR
S
-
-KY
-----------------
G
D
E
T
N
R
L
YR
QNYSLTWNGGWDN
G
V
TTSNWVQ
Y
EH
T
R
---------
N
---------
-
S
R
---
IPE
GL
A
G
GTE
GKFNEKA
T
QDFV
DIDL
D
DVMLH
SE
V
NL
PI
DFLVNQ
T
L
T
L
G
T
EW
NQQ
R
MK
D
LSSNTQA
L
TGTNTG
G
AI
D
G
VSATDRSPYSKA
E
IF
SL
---
-
--
FAE
NNME
LTD
S
T
I
V
T
P
G
L
R
F
--------
DH
------------
HSIV
GN
----------
N
WSP
ALN
I
SQG
L
G
D
D
F
T
LK
M
G
IA
R
A
YKAP
S
L
Y
Q
TNPNYI
L
YSKGQ
G
CYA
--
SA
G
GCY
L
-----
Q
GN
D
DLK
A
E
T
S
I
N
K
EIG
LEF-KRD
G
W
L
A
G
VT
W
F
R
N
D
YR
NKI
E
A
GYVAVGQ
N
A
VGTDLYQ
W
D
N
V
P
KA
V
VE
G
L
E
G
S
LNV
P
-
VSE
T
VMWTN
N
I
T
Y
M
-------
LK
SE
N
KT
---
T
G
D
----
RLS
I
IPEY
T
L
N
S
T
L
S
W
QAR
E
DLSMQTTF
T
WY
GK
QQ
P
KKY
-
NY
KGQP
AV
-----
G
PE
T
KEISP
Y
S
I
VGL
SAT
W
D
V
T
K
---
N
V
S
L
TGG
VDNLFDK
-
-
---R
L
WRA
G
N
AQT
TGDL
AG
ANYIA
G
A
G
A
---
Y
T
Y
NE
PGR
TW
Y
MS
I
N
TH
F
fig|656379.3.peg.1364
Escherichia coli FVEC1302 (47-746/746)
A
P
G
VS
T
I
TA
D
EIR
K
N
-
PVAR
D
V
SE
I
I
R
T
-
M
PGV
N
L
TGN
S
TS
G
QR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
K
P
VSSRNS
VRQG
WR
G
E
R
D
TR
G
----
D
T
SWV
PP
-
EM
IERIEVLRGP
A
A
A
R
YGN
G
A
A
GGVVNIITKKG
S
--------------
GE
W
HG
S
WD
A
YF
N
AP
E
HK
E
E
---
G
----
AT
K
RT
NF
SLT
GPL
-
G
D
EFSF
R
LY
G
NLD
K
TQ
A
D
A
WDINQ
--
GHQSARAGTYA
T
T
L
PAGR
E
GVI
N
K
D
I
N
G
VV
--
R
W
D
F
A
P
L
Q
S
L
EL
E
AGY
SRQ
GNLYA
GDT
Q
NT
N
S
D
S
Y
TR
S
-
-KY
-----------------
G
D
E
T
N
R
L
YR
QNYSLTWNGGWDN
G
V
TTSNWVQ
Y
EH
T
R
---------
N
---------
-
S
R
---
IPE
GL
A
G
GTE
GKFNEKA
T
QDFV
DIDL
D
DVMLH
SE
V
NL
PI
DFLVNQ
T
L
T
L
G
T
EW
NQQ
R
MK
D
LSSNTQA
L
TGTNTG
G
AI
D
G
VSATDRSPYSKA
E
IF
SL
---
-
--
FAE
NNME
LTD
S
T
I
V
T
P
G
L
R
F
--------
DH
------------
HSIV
GN
----------
N
WSP
ALN
I
SQG
L
G
D
D
F
T
LK
M
G
IA
R
A
YKAP
S
L
Y
Q
TNPNYI
L
YSKGQ
G
CYA
--
SA
G
GCY
L
-----
Q
GN
D
DLK
A
E
T
S
I
N
K
EIG
LEF-KRD
G
W
L
A
G
VT
W
F
R
N
D
YR
NKI
E
A
GYVAVGQ
N
A
VGTDLYQ
W
D
N
V
P
KA
V
VE
G
L
E
G
S
LNV
P
-
VSE
T
VMWTN
N
I
T
Y
M
-------
LK
SE
N
KT
---
T
G
D
----
RLS
I
IPEY
T
L
N
S
T
L
S
W
QAR
E
DLSMQTTF
T
WY
GK
QQ
P
KKY
-
NY
KGQP
AV
-----
G
PE
T
KEISP
Y
S
I
VGL
SAT
W
D
V
T
K
---
N
V
S
L
TGG
VDNLFDK
-
-
---R
L
WRA
G
N
AQT
TGDL
AG
ANYIA
G
A
G
A
---
Y
T
Y
NE
PGR
TW
Y
MS
I
N
TH
F
fig|656380.3.peg.1192
Escherichia coli FVEC1412 (47-746/746)
A
P
G
VS
T
I
TA
D
EIR
K
N
-
PVAR
D
V
SE
I
I
R
T
-
M
PGV
N
L
TGN
S
TS
G
QR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
K
P
VSSRNS
VRQG
WR
G
E
R
D
TR
G
----
D
T
SWV
PP
-
EM
IERIEVLRGP
A
A
A
R
YGN
G
A
A
GGVVNIITKKG
S
--------------
GE
W
HG
S
WD
A
YF
N
AP
E
HK
E
E
---
G
----
AT
K
RT
NF
SLT
GPL
-
G
D
EFSF
R
LY
G
NLD
K
TQ
A
D
A
WDINQ
--
GHQSARAGTYA
T
T
L
PAGR
E
GVI
N
K
D
I
N
G
VV
--
R
W
D
F
A
P
L
Q
S
L
EL
E
AGY
SRQ
GNLYA
GDT
Q
NT
N
S
D
S
Y
TR
S
-
-KY
-----------------
G
D
E
T
N
R
L
YR
QNYSLTWNGGWDN
G
V
TTSNWVQ
Y
EH
T
R
---------
N
---------
-
S
R
---
IPE
GL
A
G
GTE
GKFNEKA
T
QDFV
DIDL
D
DVMLH
SE
V
NL
PI
DFLVNQ
T
L
T
L
G
T
EW
NQQ
R
MK
D
LSSNTQA
L
TGTNTG
G
AI
D
G
VSATDRSPYSKA
E
IF
SL
---
-
--
FAE
NNME
LTD
S
T
I
V
T
P
G
L
R
F
--------
DH
------------
HSIV
GN
----------
N
WSP
ALN
I
SQG
L
G
D
D
F
T
LK
M
G
IA
R
A
YKAP
S
L
Y
Q
TNPNYI
L
YSKGQ
G
CYA
--
SA
G
GCY
L
-----
Q
GN
D
DLK
A
E
T
S
I
N
K
EIG
LEF-KRD
G
W
L
A
G
VT
W
F
R
N
D
YR
NKI
E
A
GYVAVGQ
N
A
VGTDLYQ
W
D
N
V
P
KA
V
VE
G
L
E
G
S
LNV
P
-
VSE
T
VMWTN
N
I
T
Y
M
-------
LK
SE
N
KT
---
T
G
D
----
RLS
I
IPEY
T
L
N
S
T
L
S
W
QAR
E
DLSMQTTF
T
WY
GK
QQ
P
KKY
-
NY
KGQP
AV
-----
G
PE
T
KEISP
Y
S
I
VGL
SAT
W
D
V
T
K
---
N
V
S
L
TGG
VDNLFDK
-
-
---R
L
WRA
G
N
AQT
TGDL
AG
ANYIA
G
A
G
A
---
Y
T
Y
NE
PGR
TW
Y
MS
I
N
TH
F
fig|656393.3.peg.1259
Escherichia coli H299 (47-746/746)
A
P
G
VS
T
I
TA
D
EIR
K
N
-
PVAR
D
V
SE
I
I
R
T
-
M
PGV
N
L
TGN
S
TS
G
QR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
K
P
VSSRNS
VRQG
WR
G
E
R
D
TR
G
----
D
T
SWV
PP
-
EM
IERIEVLRGP
A
A
A
R
YGN
G
A
A
GGVVNIITKKG
S
--------------
GE
W
HG
S
WD
A
YF
N
AP
E
HK
E
E
---
G
----
AT
K
RT
NF
SLT
GPL
-
G
D
EFSF
R
LY
G
NLD
K
TQ
A
D
A
WDINQ
--
GHQSARAGTYA
T
T
L
PAGR
E
GVI
N
K
D
I
N
G
VV
--
R
W
D
F
A
P
L
Q
S
L
EL
E
AGY
SRQ
GNLYA
GDT
Q
NT
N
S
D
S
Y
TR
S
-
-KY
-----------------
G
D
E
T
N
R
L
YR
QNYSLTWNGGWDN
G
V
TTSNWVQ
Y
EH
T
R
---------
N
---------
-
S
R
---
IPE
GL
A
G
GTE
GKFNEKA
T
QDFV
DIDL
D
DVMLH
SE
V
NL
PI
DFLVNQ
T
L
T
L
G
T
EW
NQQ
R
MK
D
LSSNTQA
L
TGTNTG
G
AI
D
G
VSATDRSPYSKA
E
IF
SL
---
-
--
FAE
NNME
LTD
S
T
I
V
T
P
G
L
R
F
--------
DH
------------
HSIV
GN
----------
N
WSP
ALN
I
SQG
L
G
D
D
F
T
LK
M
G
IA
R
A
YKAP
S
L
Y
Q
TNPNYI
L
YSKGQ
G
CYA
--
SA
G
GCY
L
-----
Q
GN
D
DLK
A
E
T
S
I
N
K
EIG
LEF-KRD
G
W
L
A
G
VT
W
F
R
N
D
YR
NKI
E
A
GYVAVGQ
N
A
VGTDLYQ
W
D
N
V
P
KA
V
VE
G
L
E
G
S
LNV
P
-
VSE
T
VMWTN
N
I
T
Y
M
-------
LK
SE
N
KT
---
T
G
D
----
RLS
I
IPEY
T
L
N
S
T
L
S
W
QAR
E
DLSMQTTF
T
WY
GK
QQ
P
KKY
-
NY
KGQP
AV
-----
G
PE
T
KEISP
Y
S
I
VGL
SAT
W
D
V
T
K
---
N
V
S
L
TGG
VDNLFDK
-
-
---R
L
WRA
G
N
AQT
TGDL
AG
ANYIA
G
A
G
A
---
Y
T
Y
NE
PGR
TW
Y
MS
I
N
TH
F
fig|749549.3.peg.4847
Escherichia coli MS 198-1 (47-746/746)
A
P
G
VS
T
I
TA
D
EIR
K
N
-
PVAR
D
V
SE
I
I
R
T
-
M
PGV
N
L
TGN
S
TS
G
QR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
K
P
VSSRNS
VRQG
WR
G
E
R
D
TR
G
----
D
T
SWV
PP
-
EM
IERIEVLRGP
A
A
A
R
YGN
G
A
A
GGVVNIITKKG
S
--------------
GE
W
HG
S
WD
A
YF
N
AP
E
HK
E
E
---
G
----
AT
K
RT
NF
SLT
GPL
-
G
D
EFSF
R
LY
G
NLD
K
TQ
A
D
A
WDINQ
--
GHQSARAGTYA
T
T
L
PAGR
E
GVI
N
K
D
I
N
G
VV
--
R
W
D
F
A
P
L
Q
S
L
EL
E
AGY
SRQ
GNLYA
GDT
Q
NT
N
S
D
S
Y
TR
S
-
-KY
-----------------
G
D
E
T
N
R
L
YR
QNYSLTWNGGWDN
G
V
TTSNWVQ
Y
EH
T
R
---------
N
---------
-
S
R
---
IPE
GL
A
G
GTE
GKFNEKA
T
QDFV
DIDL
D
DVMLH
SE
V
NL
PI
DFLVNQ
T
L
T
L
G
T
EW
NQQ
R
MK
D
LSSNTQA
L
TGTNTG
G
AI
D
G
VSATDRSPYSKA
E
IF
SL
---
-
--
FAE
NNME
LTD
S
T
I
V
T
P
G
L
R
F
--------
DH
------------
HSIV
GN
----------
N
WSP
ALN
I
SQG
L
G
D
D
F
T
LK
M
G
IA
R
A
YKAP
S
L
Y
Q
TNPNYI
L
YSKGQ
G
CYA
--
SA
G
GCY
L
-----
Q
GN
D
DLK
A
E
T
S
I
N
K
EIG
LEF-KRD
G
W
L
A
G
VT
W
F
R
N
D
YR
NKI
E
A
GYVAVGQ
N
A
VGTDLYQ
W
D
N
V
P
KA
V
VE
G
L
E
G
S
LNV
P
-
VSE
T
VMWTN
N
I
T
Y
M
-------
LK
SE
N
KT
---
T
G
D
----
RLS
I
IPEY
T
L
N
S
T
L
S
W
QAR
E
DLSMQTTF
T
WY
GK
QQ
P
KKY
-
NY
KGQP
AV
-----
G
PE
T
KEISP
Y
S
I
VGL
SAT
W
D
V
T
K
---
N
V
S
L
TGG
VDNLFDK
-
-
---R
L
WRA
G
N
AQT
TGDL
AG
ANYIA
G
A
G
A
---
Y
T
Y
NE
PGR
TW
Y
MS
I
N
TH
F
fig|656437.3.peg.658
Escherichia coli TA143 (47-746/746)
A
P
G
VS
T
I
TA
D
EIR
K
N
-
PVAR
D
V
SE
I
I
R
T
-
M
PGV
N
L
TGN
S
TS
G
QR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
K
P
VSSRNS
VRQG
WR
G
E
R
D
TR
G
----
D
T
SWV
PP
-
EM
IERIEVLRGP
A
A
A
R
YGN
G
A
A
GGVVNIITKKG
S
--------------
GE
W
HG
S
WD
A
YF
N
AP
E
HK
E
E
---
G
----
AT
K
RT
NF
SLT
GPL
-
G
D
EFSF
R
LY
G
NLD
K
TQ
A
D
A
WDINQ
--
GHQSARAGTYA
T
T
L
PAGR
E
GVI
N
K
D
I
N
G
VV
--
R
W
D
F
A
P
L
Q
S
L
EL
E
AGY
SRQ
GNLYA
GDT
Q
NT
N
S
D
S
Y
TR
S
-
-KY
-----------------
G
D
E
T
N
R
L
YR
QNYSLTWNGGWDN
G
V
TTSNWVQ
Y
EH
T
R
---------
N
---------
-
S
R
---
IPE
GL
A
G
GTE
GKFNEKA
T
QDFV
DIDL
D
DVMLH
SE
V
NL
PI
DFLVNQ
T
L
T
L
G
T
EW
NQQ
R
MK
D
LSSNTQA
L
TGTNTG
G
AI
D
G
VSATDRSPYSKA
E
IF
SL
---
-
--
FAE
NNME
LTD
S
T
I
V
T
P
G
L
R
F
--------
DH
------------
HSIV
GN
----------
N
WSP
ALN
I
SQG
L
G
D
D
F
T
LK
M
G
IA
R
A
YKAP
S
L
Y
Q
TNPNYI
L
YSKGQ
G
CYA
--
SA
G
GCY
L
-----
Q
GN
D
DLK
A
E
T
S
I
N
K
EIG
LEF-KRD
G
W
L
A
G
VT
W
F
R
N
D
YR
NKI
E
A
GYVAVGQ
N
A
VGTDLYQ
W
D
N
V
P
KA
V
VE
G
L
E
G
S
LNV
P
-
VSE
T
VMWTN
N
I
T
Y
M
-------
LK
SE
N
KT
---
T
G
D
----
RLS
I
IPEY
T
L
N
S
T
L
S
W
QAR
E
DLSMQTTF
T
WY
GK
QQ
P
KKY
-
NY
KGQP
AV
-----
G
PE
T
KEISP
Y
S
I
VGL
SAT
W
D
V
T
K
---
N
V
S
L
TGG
VDNLFDK
-
-
---R
L
WRA
G
N
AQT
TGDL
AG
ANYIA
G
A
G
A
---
Y
T
Y
NE
PGR
TW
Y
MS
I
N
TH
F
fig|585056.7.peg.873
Escherichia coli UMN026 (47-746/746)
A
P
G
VS
T
I
TA
D
EIR
K
N
-
PVAR
D
V
SE
I
I
R
T
-
M
PGV
N
L
TGN
S
TS
G
QR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
K
P
VSSRNS
VRQG
WR
G
E
R
D
TR
G
----
D
T
SWV
PP
-
EM
IERIEVLRGP
A
A
A
R
YGN
G
A
A
GGVVNIITKKG
S
--------------
GE
W
HG
S
WD
A
YF
N
AP
E
HK
E
E
---
G
----
AT
K
RT
NF
SLT
GPL
-
G
D
EFSF
R
LY
G
NLD
K
TQ
A
D
A
WDINQ
--
GHQSARAGTYA
T
T
L
PAGR
E
GVI
N
K
D
I
N
G
VV
--
R
W
D
F
A
P
L
Q
S
L
EL
E
AGY
SRQ
GNLYA
GDT
Q
NT
N
S
D
S
Y
TR
S
-
-KY
-----------------
G
D
E
T
N
R
L
YR
QNYSLTWNGGWDN
G
V
TTSNWVQ
Y
EH
T
R
---------
N
---------
-
S
R
---
IPE
GL
A
G
GTE
GKFNEKA
T
QDFV
DIDL
D
DVMLH
SE
V
NL
PI
DFLVNQ
T
L
T
L
G
T
EW
NQQ
R
MK
D
LSSNTQA
L
TGTNTG
G
AI
D
G
VSATDRSPYSKA
E
IF
SL
---
-
--
FAE
NNME
LTD
S
T
I
V
T
P
G
L
R
F
--------
DH
------------
HSIV
GN
----------
N
WSP
ALN
I
SQG
L
G
D
D
F
T
LK
M
G
IA
R
A
YKAP
S
L
Y
Q
TNPNYI
L
YSKGQ
G
CYA
--
SA
G
GCY
L
-----
Q
GN
D
DLK
A
E
T
S
I
N
K
EIG
LEF-KRD
G
W
L
A
G
VT
W
F
R
N
D
YR
NKI
E
A
GYVAVGQ
N
A
VGTDLYQ
W
D
N
V
P
KA
V
VE
G
L
E
G
S
LNV
P
-
VSE
T
VMWTN
N
I
T
Y
M
-------
LK
SE
N
KT
---
T
G
D
----
RLS
I
IPEY
T
L
N
S
T
L
S
W
QAR
E
DLSMQTTF
T
WY
GK
QQ
P
KKY
-
NY
KGQP
AV
-----
G
PE
T
KEISP
Y
S
I
VGL
SAT
W
D
V
T
K
---
N
V
S
L
TGG
VDNLFDK
-
-
---R
L
WRA
G
N
AQT
TGDL
AG
ANYIA
G
A
G
A
---
Y
T
Y
NE
PGR
TW
Y
MS
I
N
TH
F
fig|439855.10.peg.772
Escherichia coli SMS-3-5 (47-746/746)
A
P
G
VS
T
I
TA
D
EIR
K
N
-
PVAR
D
V
SE
I
I
R
T
-
M
PGV
N
L
TGN
S
TS
G
QR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
K
P
VSSRNS
VRQG
WR
G
E
R
D
TR
G
----
D
T
SWV
PP
-
EM
IERIEVLRGP
A
A
A
R
YGN
G
A
A
GGVVNIITKKG
S
--------------
GE
W
HG
S
WD
A
YF
N
AP
E
HK
E
E
---
G
----
AT
K
RT
NF
SLT
GPL
-
G
D
EFSF
R
LY
G
NLD
K
TQ
A
D
A
WDINQ
--
GHQSARAGTYA
T
T
L
PAGR
E
GVI
N
K
D
I
N
G
VV
--
R
W
D
F
A
P
L
Q
S
L
EL
E
AGY
SRQ
GNLYA
GDT
Q
NT
N
S
D
A
Y
TR
S
-
-KY
-----------------
G
D
E
T
N
R
L
YR
QNYSLTWNGGWDN
G
V
TTSNWVQ
Y
EH
T
R
---------
N
---------
-
S
R
---
IPE
GL
A
G
GTE
GKFNEKA
A
QDFV
DIDL
D
DVMLH
SE
V
NL
PI
DFLVNQ
T
L
T
L
G
T
EW
NQQ
R
MK
D
LSSNTQA
L
TGTNTG
G
AI
D
G
VSATDRSPYSKA
E
IF
SL
---
-
--
FAE
NNME
LTD
S
T
I
V
T
P
G
L
R
F
--------
DH
------------
HSIV
GN
----------
N
WSP
ALN
I
SQG
L
G
D
D
F
T
LK
M
G
IA
R
A
YKAP
S
L
Y
Q
TNPNYI
L
YSKGQ
G
CYA
--
SA
G
GCY
L
-----
Q
GN
D
DLK
A
E
T
S
I
N
K
EIG
LEF-KRD
G
W
L
A
G
VT
W
F
R
N
D
YR
NKI
E
A
GYVAVGQ
N
A
AGTDLYQ
W
D
N
V
P
KA
V
VE
G
L
E
G
S
LNV
P
-
VSE
T
VMWTN
N
I
T
Y
M
-------
LK
SE
N
KT
---
T
G
D
----
RLS
I
IPEY
T
L
N
S
T
L
S
W
QAR
E
DLSMQTTF
T
WY
GK
QQ
P
KKY
-
NY
KGQP
AV
-----
G
PE
T
KEISP
Y
S
I
VGL
SAT
W
D
V
T
K
---
N
V
S
L
TGG
VDNLFDK
-
-
---R
L
WRA
G
N
AQT
TGDL
AG
ANYIA
G
A
G
A
---
Y
T
Y
NE
PGR
TW
Y
MSVN
TH
F
fig|656444.3.peg.1059
Escherichia coli TA280 (47-746/746)
A
P
G
VS
T
I
TA
D
EIR
K
N
-
PVAR
D
V
SE
I
I
R
T
-
M
PGV
N
L
TGN
S
TS
G
QR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
K
P
VSSRNS
VRQG
WR
G
E
R
D
TR
G
----
D
T
SWV
PP
-
EM
IERIEVLRGP
A
A
A
R
YGN
G
A
A
GGVVNIITKKG
S
--------------
GE
W
HG
S
WD
A
YF
N
AP
E
HK
E
E
---
G
----
AT
K
RT
NF
SLT
GPL
-
G
D
EFSF
R
LY
G
NLD
K
TQ
A
D
A
WDINQ
--
GHQSARAGTYA
T
T
L
PAGR
E
GVI
N
K
D
I
N
G
VV
--
R
W
D
L
A
P
L
Q
S
L
EL
E
AGY
SRQ
GNLYA
GDT
Q
NT
N
S
D
S
Y
TR
S
-
-KY
-----------------
G
D
E
T
N
R
L
YR
QNYSLTWNGGWDN
G
V
TTSNWVQ
Y
EH
T
R
---------
N
---------
-
S
R
---
IPE
GL
A
G
GTE
GKFNEKA
T
QDFV
DIDL
D
DVMLH
SE
V
NL
PI
DFLVNQ
T
L
T
L
G
T
EW
NQQ
R
MK
D
LSSNTQA
L
TGTNTG
G
AI
D
G
VSATDRSPYSKA
E
IF
SL
---
-
--
FAE
NNME
LTD
S
T
I
V
T
P
G
L
R
F
--------
DH
------------
HSIV
GN
----------
N
WSP
ALN
I
SQG
L
G
D
D
F
T
LK
M
G
IA
R
A
YKAP
S
L
Y
Q
TNPNYI
L
YSKGQ
G
CYA
--
SA
G
GCY
L
-----
Q
GN
D
DLK
A
E
T
S
I
N
K
EIG
LEF-KRD
G
W
L
A
G
I
T
W
F
R
N
D
YR
NKI
E
A
GYVAVGQ
N
A
VGTDLYQ
W
D
N
V
P
KA
V
VE
G
L
E
G
S
LNV
P
-
VSE
T
VMWTN
N
I
T
Y
M
-------
LK
SE
N
KT
---
T
G
D
----
RLS
I
IPEY
T
L
N
S
T
L
S
W
QAR
E
DLSMQTTF
T
WY
GK
QQ
P
KKY
-
NY
KGQP
AV
-----
G
PE
T
KEISP
Y
S
I
VGL
SAT
W
D
V
T
K
---
N
V
S
L
TGG
VDNLFDK
-
-
---R
L
WRA
G
N
AQT
TGDL
AG
ANYIA
G
A
G
A
---
Y
T
Y
NE
PGR
TW
Y
MS
I
N
TH
F
fig|749531.3.peg.4123
Escherichia coli MS 69-1 (47-746/746)
A
P
G
VS
T
I
TA
D
EIR
K
N
-
PVAR
D
V
SE
I
I
R
T
-
M
PGV
N
L
TGN
S
TS
G
QR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
K
P
VSSRNS
VRQG
WR
G
E
R
D
TR
G
----
D
T
SWV
PP
-
EM
IERIEVLRGP
A
A
A
R
YGN
G
A
A
GGVVNIITKKG
S
--------------
GE
W
HG
S
WD
A
YF
N
AP
E
HK
E
E
---
G
----
AT
K
RT
NF
SLT
GPL
-
G
D
EFSF
R
LY
G
NLD
K
TQ
A
D
A
WDINQ
--
GHQSARAGTYA
T
T
L
PAGR
E
GVI
N
K
D
I
N
G
VV
--
R
W
D
F
A
P
L
Q
S
L
EL
E
AGY
SRQ
GNLYA
GDT
Q
NT
N
S
D
S
Y
TR
S
-
-KY
-----------------
G
D
E
T
N
R
L
YR
QNYSLTWNGGWDN
G
V
TTSNWVQ
Y
EH
T
R
---------
N
---------
-
S
R
---
IPE
GL
A
G
GTE
GKFNEKA
T
QDFV
DIDL
D
DVMLH
SE
V
NL
PI
DFLINQ
T
L
T
L
G
T
EW
NQQ
R
MK
D
LSSNTQA
L
TGTNTG
G
AI
D
G
VSATDRSPYSKA
E
IF
SL
---
-
--
FAE
NNME
LTD
S
T
I
V
T
P
G
L
R
F
--------
DH
------------
HSIV
GN
----------
N
WSP
ALN
I
SQG
L
G
D
D
F
T
LK
M
G
IA
R
A
YKAP
S
L
Y
Q
TNPNYI
L
YSKGQ
G
CYA
--
SA
G
GCY
L
-----
Q
GN
D
DLK
A
E
T
S
I
N
K
EIG
LEF-KRD
G
W
L
A
G
VT
W
F
R
N
D
YR
NKI
E
A
GYVAVGQ
N
A
VGTDLYQ
W
D
N
V
P
KA
V
VE
G
L
E
G
S
LNV
P
-
VSE
T
VMWTN
N
I
T
Y
M
-------
LK
SE
N
KT
---
T
G
D
----
RLS
I
IPEY
T
L
N
S
T
L
S
W
QAR
E
DLSMQTTF
T
WY
GK
QQ
P
KKY
-
NY
KGQP
AV
-----
G
PE
T
KEISP
Y
S
I
VGL
SAT
W
D
V
T
K
---
N
V
S
L
TGG
VDNLFDK
-
-
---R
L
WRA
G
N
AQT
TGDL
AG
ANYIA
G
A
G
A
---
Y
T
Y
NE
PGR
TW
Y
MS
I
N
TH
F
fig|749546.3.peg.3409
Escherichia coli MS 185-1 (47-746/746)
A
P
G
VS
T
I
TA
D
EIR
K
N
-
PVAR
D
V
SE
I
I
R
T
-
M
PGV
N
L
TGN
S
TS
G
QR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
K
P
VSSRNS
VRQG
WR
G
E
R
D
TR
G
----
D
T
SWV
PP
-
EM
IERIEVLRGP
A
A
A
R
YGN
G
A
A
GGVVNIITKKG
S
--------------
GE
W
HG
S
WD
A
YF
N
AP
E
HK
E
E
---
G
----
AT
K
RT
NF
SLT
GPL
-
G
D
EFSF
R
LY
G
NLD
K
TQ
A
D
A
WDINQ
--
GHQSARAGTYA
T
T
L
PAGR
E
GVI
N
K
D
I
N
G
VV
--
R
W
D
F
A
P
L
Q
S
L
EL
E
AGY
SRQ
GNLYA
GDT
Q
NT
N
S
D
A
Y
TR
S
-
-KY
-----------------
G
D
E
T
N
R
L
YR
QNYSLTWNGGWDN
G
V
TTSNWVQ
Y
EH
T
R
---------
N
---------
-
S
R
---
IPE
GL
A
G
GTE
GKFNEKA
A
QDFV
DIDL
D
DVMLH
SE
V
NL
PI
DFLVNQ
T
L
T
L
G
T
EW
NQQ
R
MK
D
LSSNTQA
L
TGTNTG
G
AI
D
G
VSATDRSPYSKA
E
IF
SL
---
-
--
FAE
NNME
LTD
S
T
I
V
T
P
G
L
R
F
--------
DH
------------
HSIV
GN
----------
N
WSP
ALN
I
SQG
L
G
D
D
F
T
LK
M
G
IA
R
A
YKAP
S
L
Y
Q
TNPNYI
L
YSKGQ
G
CYA
--
SA
G
GCY
L
-----
Q
GN
D
DLK
A
E
T
S
I
N
K
EIG
LEF-KRD
G
W
L
A
G
VT
W
F
R
N
D
YR
NKI
E
A
GYVAVGQ
N
A
VGTDLYQ
W
D
N
V
P
KA
V
VE
G
L
E
G
S
LNV
P
-
VSE
T
VMWTN
N
I
T
Y
M
-------
LK
SE
N
KT
---
T
G
D
----
RLS
I
IPEY
T
L
N
S
T
L
S
W
QAR
E
DLSMQTTF
T
WY
GK
QQ
P
KKY
-
NY
KGQP
AV
-----
G
PE
T
KEISP
Y
S
I
VGL
SAT
W
D
V
T
K
---
N
V
S
L
TGG
VDNLFDK
-
-
---R
L
WRA
G
N
AQT
TGDL
AG
VNYIA
G
A
G
A
---
Y
T
Y
NE
PGR
TW
Y
MS
I
N
TH
F
fig|749527.3.peg.4221
Escherichia coli MS 21-1 (47-746/746)
A
P
G
VS
T
I
TA
D
EIR
K
N
-
PVAR
D
V
SE
I
I
R
T
-
M
PGV
N
L
TGN
S
TS
G
QR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
K
P
VSSRNS
VRQG
WR
G
E
R
D
TR
G
----
D
T
SWV
PP
-
EM
IERIEVLRGP
A
A
A
R
YGN
G
A
A
GGVVNIITKKG
S
--------------
GE
W
HG
S
WD
A
YF
N
AP
E
HK
E
E
---
G
----
AT
K
RT
NF
SLT
GPL
-
G
D
EFSF
R
LY
G
NLD
K
TQ
A
D
A
WDINQ
--
GHQSARAGTYA
T
T
L
PAGR
E
GVI
N
K
D
I
N
G
VV
--
R
W
D
F
A
P
L
Q
S
L
EL
E
AGY
SRQ
GNLYA
GDT
Q
NT
N
S
D
S
Y
TR
S
-
-KY
-----------------
G
D
E
T
N
R
L
YR
QNYSLTWNGGWDN
G
V
TTSNWVQ
Y
EH
T
R
---------
N
---------
-
S
R
---
IPE
GL
A
G
GTE
GKFNEKA
T
QDFV
DIDL
D
DVMLH
SE
V
NL
PI
DFLVNQ
T
L
T
L
G
T
EW
NQQ
R
MK
D
LSSNTQA
L
TGTNTG
G
AI
D
G
VSATDRSPYSKA
E
IF
SL
---
-
--
FAE
NNME
LTD
S
T
I
V
T
P
G
L
R
F
--------
DH
------------
HSIV
GN
----------
N
WSP
ALN
I
SQG
L
G
D
D
F
T
LK
M
G
IA
R
A
YKAP
S
L
Y
Q
TNPNYI
L
YSKGQ
G
CYA
--
SA
G
GCY
L
-----
Q
GN
D
DLK
A
E
T
S
I
N
K
EIG
LEF-KRD
G
W
L
A
G
VT
W
F
R
N
D
YR
NKI
E
A
GYVAVGQ
N
A
VGTDLYQ
W
D
N
V
P
KA
V
VE
G
L
E
G
S
LNV
P
-
VSE
T
VMWTN
N
I
T
Y
M
-------
LK
SE
N
KT
---
T
G
D
----
RLS
I
IPEY
T
L
N
S
T
L
S
W
QAR
E
DLSMQTTF
T
WY
GK
QQ
P
KKY
-
NY
KGQP
AV
-----
G
PE
T
KEISP
Y
S
I
VGL
SAT
W
D
V
T
K
---
N
V
S
L
TGG
VDNLFDK
-
-
---R
L
WRA
G
N
AQT
TGDL
AG
ANYIA
G
A
G
A
---
Y
T
Y
NE
PGR
TW
Y
MSVN
TH
F
fig|585035.6.peg.618
Escherichia coli S88 (47-746/746)
A
P
G
VS
T
I
TA
D
EIR
K
N
-
PVAR
D
V
SE
I
I
R
T
-
M
PGV
N
L
TGN
S
TS
G
QR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
K
P
VSSRNS
VRQG
WR
G
E
R
D
TR
G
----
D
T
SWV
PP
-
EM
IERIEVLRGP
A
A
A
R
YGN
G
A
A
GGVVNIITKKG
S
--------------
GE
W
HG
S
WD
A
YF
N
AP
E
HK
E
E
---
G
----
AT
K
RT
NF
SLT
GPL
-
G
D
EFSF
R
LY
G
NLD
K
TQ
A
D
A
WDINQ
--
GHQSARAGTYA
T
T
L
PAGR
E
GVI
N
K
D
I
N
G
VV
--
R
W
D
F
A
P
L
Q
S
L
EL
E
AGY
SRQ
GNLYA
GDT
Q
NT
N
S
D
A
Y
TR
S
-
-KY
-----------------
G
Y
E
T
N
R
L
YR
QNYSLTWNGGWDN
G
V
TTSNWVQ
Y
EH
T
R
---------
N
---------
-
S
R
---
IPE
GL
A
G
GTE
GKFNEKA
A
QDFV
DIDL
D
DVMLH
SE
V
NL
PI
DFLVNQ
T
L
T
L
G
T
EW
NQQ
R
MK
D
LSSNTQA
L
TGTNTG
G
AI
D
G
VSATDRSPYSKA
E
IF
SL
---
-
--
FAE
NNME
LTD
S
T
I
V
T
P
G
L
R
F
--------
DH
------------
HSIV
GN
----------
N
WSP
ALN
I
SQG
L
G
D
D
F
T
LK
M
G
IA
R
A
YKAP
S
L
Y
Q
TNPNYI
L
YSKGQ
G
CYA
--
SA
G
GCY
L
-----
Q
GN
D
DLK
A
E
T
S
I
N
K
EIG
LEF-KRD
G
W
L
A
G
VT
W
F
R
N
D
YR
NKI
E
A
GYVAVGQ
N
A
VGTDLYQ
W
D
N
V
P
KA
V
VE
G
L
E
G
S
LNV
P
-
VSE
T
VMWTN
N
I
T
Y
M
-------
LK
SE
N
KT
---
T
G
D
----
RLS
I
IPEY
T
L
N
S
T
L
S
W
QAR
E
DLSMQTTF
T
WY
GK
QQ
P
KKY
-
NY
KGQP
AV
-----
G
PE
T
KEISP
Y
S
I
VGL
SAT
W
D
V
T
K
---
N
V
S
L
TGG
VDNLFDK
-
-
---R
L
WRA
G
N
AQT
TGDL
AG
ANYIA
G
A
G
A
---
Y
T
Y
NE
PGR
TW
Y
MS
I
N
TH
F
fig|550676.3.peg.48
Escherichia coli B185 (47-746/746)
A
P
G
VS
T
I
TA
D
EIR
K
N
-
PVAR
D
V
SE
I
I
R
T
-
M
PGV
N
L
TGN
S
TS
G
QR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
K
P
VSSRNS
VRQG
WR
G
E
R
D
TR
G
----
D
T
SWV
PP
-
EM
IERIEVLRGP
A
A
A
R
YGN
G
A
A
GGVVNIITKKG
S
--------------
GE
W
HG
S
WD
A
YF
N
AP
E
HK
E
E
---
G
----
AT
K
RT
NF
SLT
GPL
-
G
D
EFSF
R
LY
G
NLD
K
TQ
A
D
A
WDINQ
--
GHQSARAGTYA
T
T
L
PAGR
E
GVI
N
K
D
I
N
G
VV
--
R
W
D
F
A
P
L
Q
S
L
EL
E
AGY
SRQ
GNLYA
GDT
Q
NT
N
S
D
A
Y
TR
S
-
-KY
-----------------
G
D
E
T
N
R
L
YR
QNYSLTWNGGWDN
G
V
TTSNWVQ
Y
EH
T
R
---------
N
---------
-
S
R
---
IPE
GL
A
G
GTE
GKFNEKA
T
QDFV
DIDL
D
DVMLH
SE
V
NL
PI
DFLVNQ
T
L
T
L
G
T
EW
NQQ
R
MK
D
LSSNTQA
L
TGTNTG
G
AI
D
G
VSATDRSPYSKA
E
IF
SL
---
-
--
FAE
NNME
LTD
S
T
I
V
T
P
G
L
R
F
--------
DH
------------
HSIV
GN
----------
N
WSP
ALN
I
SQG
L
G
D
D
F
T
LK
M
G
IA
R
A
YKAP
S
L
Y
Q
TNPNYI
L
YSKGQ
G
CYA
--
SA
G
GCY
L
-----
Q
GN
D
DLK
A
E
T
S
I
N
K
EIG
LEF-KRD
G
W
L
A
G
I
T
W
F
R
N
D
YR
NKI
E
A
GYVAVGQ
N
A
VGTDLYQ
W
D
N
V
P
KA
V
VE
G
L
E
G
S
LNV
P
-
VSE
T
VMWTN
N
I
T
Y
M
-------
LK
SE
N
KT
---
T
G
D
----
RLS
I
IPEY
T
L
N
S
T
L
S
W
QAR
E
DLSMQTTF
T
WY
GK
QQ
P
KKY
-
NY
KGQP
AV
-----
G
PE
T
KEISP
Y
S
I
VGL
SAT
W
D
V
T
K
---
N
V
S
L
TGG
VDNLFDK
-
-
---R
L
WRA
G
N
AQT
TGDL
AG
ANYIA
G
A
G
A
---
Y
T
Y
NE
PGR
TW
Y
MSVN
TH
F
fig|656419.3.peg.860
Escherichia coli M718 (47-746/746)
A
P
G
VS
T
I
TA
D
EIR
K
N
-
PVAR
D
V
SE
I
I
R
T
-
M
PGV
N
L
TGN
S
TS
G
QR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
K
P
VSSRNS
VRQG
WR
G
E
R
D
TR
G
----
D
T
SWV
PP
-
EM
IERIEVLRGP
A
A
A
R
YGN
G
A
A
GGVVNIITKKG
S
--------------
GE
W
HG
S
WD
A
YF
N
AP
E
HK
E
E
---
G
----
AT
K
RT
NF
SLT
GPL
-
G
D
EFSF
R
LY
G
NLD
K
TQ
A
D
A
WDINQ
--
GHQSARAGTYA
T
T
L
PAGR
E
GVI
N
K
D
I
N
G
VV
--
R
W
D
F
A
P
L
Q
S
L
EL
E
AGY
SRQ
GNLYA
GDT
Q
NT
N
S
D
A
Y
TR
S
-
-KY
-----------------
G
D
E
T
N
R
L
YR
QNYSLTWNGGWDN
G
V
TTSNWVQ
Y
EH
T
R
---------
N
---------
-
S
R
---
IPE
GL
A
G
GTE
GKFNEKA
T
QDFV
DIDL
D
DVMLH
SE
V
NL
PI
DFLVNQ
T
L
T
L
G
T
EW
NQQ
R
MK
D
LSSNTQA
L
TGTNTG
G
AI
D
G
VSATDRSPYSKA
E
IF
SL
---
-
--
FAE
NNME
LTD
S
T
I
V
T
P
G
L
R
F
--------
DH
------------
HSIV
GN
----------
N
WSP
ALN
I
SQG
L
G
D
D
F
T
LK
M
G
IA
R
A
YKAP
S
L
Y
Q
TNPNYI
L
YSKGQ
G
CYA
--
SA
G
GCY
L
-----
Q
GN
D
DLK
A
E
T
S
I
N
K
EIG
LEF-KRD
G
W
L
A
G
I
T
W
F
R
N
D
YR
NKI
E
A
GYVAVGQ
N
A
VGTDLYQ
W
D
N
V
P
KA
V
VE
G
L
E
G
S
LNV
P
-
VSE
T
VMWTN
N
I
T
Y
M
-------
LK
SE
N
KT
---
T
G
D
----
RLS
I
IPEY
T
L
N
S
T
L
S
W
QAR
E
DLSMQTTF
T
WY
GK
QQ
P
KKY
-
NY
KGQP
AV
-----
G
PE
T
KEISP
Y
S
I
VGL
SAT
W
D
V
T
K
---
N
V
S
L
TGG
VDNLFDK
-
-
---R
L
WRA
G
N
AQT
TGDL
AG
ANYIA
G
A
G
A
---
Y
T
Y
NE
PGR
TW
Y
MSVN
TH
F
fig|344610.3.peg.1570
Escherichia coli 53638 (47-746/746)
A
P
G
VS
T
I
TA
D
EIR
K
N
-
PVAR
D
V
SE
I
I
R
T
-
M
PGV
N
L
TGN
S
TS
G
QR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
K
P
VSSRNS
VRQG
WR
G
E
R
D
TR
G
----
D
T
SWV
PP
-
EM
IERIEVLRGP
A
A
A
R
YGN
G
A
A
GGVVNIITKKG
S
--------------
GE
W
HG
S
WD
A
YF
N
AP
E
HK
E
E
---
G
----
AT
K
RT
NF
SLT
GPL
-
G
D
EFSF
R
LY
G
NLD
K
TQ
A
D
A
WDINQ
--
GHQSARAGTYA
T
T
L
PAGR
E
GVI
N
K
D
I
N
G
VV
--
R
W
D
F
A
P
L
Q
S
L
EL
E
AGY
SRQ
GNLYA
GDT
Q
NT
N
S
D
A
Y
TR
S
-
-KY
-----------------
G
D
E
T
N
R
L
YR
QNYSLTWNGGWDN
G
V
TTSNWVQ
Y
EH
T
R
---------
N
---------
-
S
R
---
IPE
GL
A
G
GTE
GKFNEKA
T
QDFV
DIDL
D
DVMLH
SE
V
NL
PI
DFLVNQ
T
L
T
L
G
T
EW
NQQ
R
MK
D
LSSNTQA
L
TGTNTG
G
AI
D
G
VSATDRSPYSKA
E
IF
SL
---
-
--
FAE
NNME
LTD
S
T
I
V
T
P
G
L
R
F
--------
DH
------------
HSIV
GN
----------
N
WSP
ALN
I
SQG
L
G
D
D
F
T
LK
M
G
IA
R
A
YKAP
S
L
Y
Q
TNPNYI
L
YSKGQ
G
CYA
--
SA
G
GCY
L
-----
Q
GN
D
DLK
A
E
T
S
I
N
K
EIG
LEF-KRD
G
W
L
A
G
VT
W
F
R
N
D
YR
NKI
E
A
GYVAVGQ
N
A
VGTDLYQ
W
D
N
V
P
KA
V
VE
G
L
E
G
S
LNV
P
-
VSE
T
VMWTN
N
I
T
Y
M
-------
LK
SE
N
KT
---
T
G
D
----
RLS
I
IPEY
T
L
N
S
T
L
S
W
QAR
E
DLSMQTTF
T
WY
GK
QQ
P
KKY
-
NY
KGQP
AV
-----
G
PE
T
KEISP
Y
S
I
VGL
SAT
W
D
V
T
K
---
N
V
S
L
TGG
VDNLFDK
-
-
---R
L
WRA
G
N
AQT
TGDL
AG
ANYIA
G
A
G
A
---
Y
T
Y
NE
PGR
TW
Y
MSVN
TH
F
fig|344610.7.peg.1109
Escherichia coli 53638 (47-746/746)
A
P
G
VS
T
I
TA
D
EIR
K
N
-
PVAR
D
V
SE
I
I
R
T
-
M
PGV
N
L
TGN
S
TS
G
QR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
K
P
VSSRNS
VRQG
WR
G
E
R
D
TR
G
----
D
T
SWV
PP
-
EM
IERIEVLRGP
A
A
A
R
YGN
G
A
A
GGVVNIITKKG
S
--------------
GE
W
HG
S
WD
A
YF
N
AP
E
HK
E
E
---
G
----
AT
K
RT
NF
SLT
GPL
-
G
D
EFSF
R
LY
G
NLD
K
TQ
A
D
A
WDINQ
--
GHQSARAGTYA
T
T
L
PAGR
E
GVI
N
K
D
I
N
G
VV
--
R
W
D
F
A
P
L
Q
S
L
EL
E
AGY
SRQ
GNLYA
GDT
Q
NT
N
S
D
A
Y
TR
S
-
-KY
-----------------
G
D
E
T
N
R
L
YR
QNYSLTWNGGWDN
G
V
TTSNWVQ
Y
EH
T
R
---------
N
---------
-
S
R
---
IPE
GL
A
G
GTE
GKFNEKA
T
QDFV
DIDL
D
DVMLH
SE
V
NL
PI
DFLVNQ
T
L
T
L
G
T
EW
NQQ
R
MK
D
LSSNTQA
L
TGTNTG
G
AI
D
G
VSATDRSPYSKA
E
IF
SL
---
-
--
FAE
NNME
LTD
S
T
I
V
T
P
G
L
R
F
--------
DH
------------
HSIV
GN
----------
N
WSP
ALN
I
SQG
L
G
D
D
F
T
LK
M
G
IA
R
A
YKAP
S
L
Y
Q
TNPNYI
L
YSKGQ
G
CYA
--
SA
G
GCY
L
-----
Q
GN
D
DLK
A
E
T
S
I
N
K
EIG
LEF-KRD
G
W
L
A
G
VT
W
F
R
N
D
YR
NKI
E
A
GYVAVGQ
N
A
VGTDLYQ
W
D
N
V
P
KA
V
VE
G
L
E
G
S
LNV
P
-
VSE
T
VMWTN
N
I
T
Y
M
-------
LK
SE
N
KT
---
T
G
D
----
RLS
I
IPEY
T
L
N
S
T
L
S
W
QAR
E
DLSMQTTF
T
WY
GK
QQ
P
KKY
-
NY
KGQP
AV
-----
G
PE
T
KEISP
Y
S
I
VGL
SAT
W
D
V
T
K
---
N
V
S
L
TGG
VDNLFDK
-
-
---R
L
WRA
G
N
AQT
TGDL
AG
ANYIA
G
A
G
A
---
Y
T
Y
NE
PGR
TW
Y
MSVN
TH
F
fig|1040638.4.peg.5274
Escherichia coli O104:H4 str. LB226692 (47-746/746)
A
P
G
VS
T
I
TA
D
EIR
K
N
-
PVAR
D
V
SE
I
I
R
T
-
M
PGV
N
L
TGN
S
TS
G
QR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
K
P
VSSRNS
VRQG
WR
G
E
R
D
TR
G
----
D
T
SWV
PP
-
EM
IERIEVLRGP
A
A
A
R
YGN
G
A
A
GGVVNIITKKG
S
--------------
GE
W
HG
S
WD
A
YF
N
AP
E
HK
E
E
---
G
----
AT
K
RT
NF
SLT
GPL
-
G
D
EFSF
R
LY
G
NLD
K
TQ
A
D
A
WDINQ
--
GHQSARAGTYA
T
T
L
PAGR
E
GVI
N
K
D
I
N
G
VV
--
R
W
D
F
A
P
L
Q
S
L
EL
E
AGY
SRQ
GNLYA
GDT
Q
NT
N
S
D
A
Y
TR
S
-
-KY
-----------------
G
D
E
T
N
R
L
YR
QNYALTWNGGWDN
G
V
TTSNWVQ
Y
EH
T
R
---------
N
---------
-
S
R
---
IPE
GL
A
G
GTE
GKFNEKA
T
QDFV
DIDL
D
DVMLH
SE
V
NL
PI
DFLVNQ
T
L
T
L
G
T
EW
NQQ
R
MK
D
LSSNTQA
L
TGANTG
G
AI
D
G
VSATDRSPYSKA
E
IF
SL
---
-
--
FAE
NNME
LTD
S
T
I
V
T
P
G
L
R
F
--------
DH
------------
HSIV
GN
----------
N
WSP
ALN
I
SQG
L
G
D
D
F
T
LK
M
G
IA
R
A
YKAP
S
L
Y
Q
TNPNYI
L
YSKGQ
G
CYA
--
SA
G
GCY
L
-----
Q
GN
D
DLK
A
E
T
S
I
N
K
EIG
LEF-KRD
G
W
L
A
G
VT
W
F
R
N
D
YR
NKI
E
A
GYVAVGQ
N
A
VGTDLYQ
W
D
N
V
P
KA
V
VE
G
L
E
G
S
LNV
P
-
VSE
T
VMWTN
N
I
T
Y
M
-------
LK
SE
N
KT
---
T
G
D
----
RLS
I
IPEY
T
L
N
S
T
L
S
W
QAR
E
DLSMQTTF
T
WY
GK
QQ
P
KKY
-
NY
KGQP
AV
-----
G
PE
T
KEISP
Y
S
I
VGL
SAT
W
D
V
T
K
---
N
V
S
L
TGG
VDNLFDK
-
-
---R
L
WRA
G
N
AQT
TGDL
AG
ANYIA
G
A
G
A
---
Y
T
Y
NE
PGR
TW
Y
MSVN
TH
F
fig|6666666.5357.peg.1810
Escherichia coli TY-2482 (47-746/746)
A
P
G
VS
T
I
TA
D
EIR
K
N
-
PVAR
D
V
SE
I
I
R
T
-
M
PGV
N
L
TGN
S
TS
G
QR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
K
P
VSSRNS
VRQG
WR
G
E
R
D
TR
G
----
D
T
SWV
PP
-
EM
IERIEVLRGP
A
A
A
R
YGN
G
A
A
GGVVNIITKKG
S
--------------
GE
W
HG
S
WD
A
YF
N
AP
E
HK
E
E
---
G
----
AT
K
RT
NF
SLT
GPL
-
G
D
EFSF
R
LY
G
NLD
K
TQ
A
D
A
WDINQ
--
GHQSARAGTYA
T
T
L
PAGR
E
GVI
N
K
D
I
N
G
VV
--
R
W
D
F
A
P
L
Q
S
L
EL
E
AGY
SRQ
GNLYA
GDT
Q
NT
N
S
D
A
Y
TR
S
-
-KY
-----------------
G
D
E
T
N
R
L
YR
QNYALTWNGGWDN
G
V
TTSNWVQ
Y
EH
T
R
---------
N
---------
-
S
R
---
IPE
GL
A
G
GTE
GKFNEKA
T
QDFV
DIDL
D
DVMLH
SE
V
NL
PI
DFLVNQ
T
L
T
L
G
T
EW
NQQ
R
MK
D
LSSNTQA
L
TGANTG
G
AI
D
G
VSATDRSPYSKA
E
IF
SL
---
-
--
FAE
NNME
LTD
S
T
I
V
T
P
G
L
R
F
--------
DH
------------
HSIV
GN
----------
N
WSP
ALN
I
SQG
L
G
D
D
F
T
LK
M
G
IA
R
A
YKAP
S
L
Y
Q
TNPNYI
L
YSKGQ
G
CYA
--
SA
G
GCY
L
-----
Q
GN
D
DLK
A
E
T
S
I
N
K
EIG
LEF-KRD
G
W
L
A
G
VT
W
F
R
N
D
YR
NKI
E
A
GYVAVGQ
N
A
VGTDLYQ
W
D
N
V
P
KA
V
VE
G
L
E
G
S
LNV
P
-
VSE
T
VMWTN
N
I
T
Y
M
-------
LK
SE
N
KT
---
T
G
D
----
RLS
I
IPEY
T
L
N
S
T
L
S
W
QAR
E
DLSMQTTF
T
WY
GK
QQ
P
KKY
-
NY
KGQP
AV
-----
G
PE
T
KEISP
Y
S
I
VGL
SAT
W
D
V
T
K
---
N
V
S
L
TGG
VDNLFDK
-
-
---R
L
WRA
G
N
AQT
TGDL
AG
ANYIA
G
A
G
A
---
Y
T
Y
NE
PGR
TW
Y
MSVN
TH
F
fig|585055.6.peg.586
Escherichia coli 55989 (47-746/746)
A
P
G
VS
T
I
TA
D
EIR
K
N
-
PVAR
D
V
SE
I
I
R
T
-
M
PGV
N
L
TGN
S
TS
G
QR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
K
P
VSSRNS
VRQG
WR
G
E
R
D
TR
G
----
D
T
SWV
PP
-
EM
IERIEVLRGP
A
A
A
R
YGN
G
A
A
GGVVNIITKKG
S
--------------
GE
W
HG
S
WD
A
YF
N
AP
E
HK
E
E
---
G
----
AT
K
RT
NF
SLT
GPL
-
G
D
EFSF
R
LY
G
NLD
K
TQ
A
D
A
WDINQ
--
GHQSARAGTYA
T
T
L
PAGR
E
GVI
N
K
D
I
N
G
VV
--
R
W
D
F
A
P
L
Q
S
L
EL
E
AGY
SRQ
GNLYA
GDT
Q
NT
N
S
D
A
Y
TR
S
-
-KY
-----------------
G
D
E
T
N
R
L
YR
QNYALTWNGGWDN
G
V
TTSNWVQ
Y
EH
T
R
---------
N
---------
-
S
R
---
IPE
GL
A
G
GTE
GKFNEKA
T
QDFV
DIDL
D
DVMLH
SE
V
NL
PI
DFLVNQ
T
L
T
L
G
T
EW
NQQ
R
MK
D
LSSNTQA
L
TGANTG
G
AI
D
G
VSATDRSPYSKA
E
IF
SL
---
-
--
FAE
NNME
LTD
S
T
I
V
T
P
G
L
R
F
--------
DH
------------
HSIV
GN
----------
N
WSP
ALN
I
SQG
L
G
D
D
F
T
LK
M
G
IA
R
A
YKAP
S
L
Y
Q
TNPNYI
L
YSKGQ
G
CYA
--
SA
G
GCY
L
-----
Q
GN
D
DLK
A
E
T
S
I
N
K
EIG
LEF-KRD
G
W
L
A
G
VT
W
F
R
N
D
YR
NKI
E
A
GYVAVGQ
N
A
VGTDLYQ
W
D
N
V
P
KA
V
VE
G
L
E
G
S
LNV
P
-
VSE
T
VMWTN
N
I
T
Y
M
-------
LK
SE
N
KT
---
T
G
D
----
RLS
I
IPEY
T
L
N
S
T
L
S
W
QAR
E
DLSMQTTF
T
WY
GK
QQ
P
KKY
-
NY
KGQP
AV
-----
G
PE
T
KEISP
Y
S
I
VGL
SAT
W
D
V
T
K
---
N
V
S
L
TGG
VDNLFDK
-
-
---R
L
WRA
G
N
AQT
TGDL
AG
ANYIA
G
A
G
A
---
Y
T
Y
NE
PGR
TW
Y
MSVN
TH
F
fig|585055.8.peg.587
Escherichia coli 55989 (47-746/746)
A
P
G
VS
T
I
TA
D
EIR
K
N
-
PVAR
D
V
SE
I
I
R
T
-
M
PGV
N
L
TGN
S
TS
G
QR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
K
P
VSSRNS
VRQG
WR
G
E
R
D
TR
G
----
D
T
SWV
PP
-
EM
IERIEVLRGP
A
A
A
R
YGN
G
A
A
GGVVNIITKKG
S
--------------
GE
W
HG
S
WD
A
YF
N
AP
E
HK
E
E
---
G
----
AT
K
RT
NF
SLT
GPL
-
G
D
EFSF
R
LY
G
NLD
K
TQ
A
D
A
WDINQ
--
GHQSARAGTYA
T
T
L
PAGR
E
GVI
N
K
D
I
N
G
VV
--
R
W
D
F
A
P
L
Q
S
L
EL
E
AGY
SRQ
GNLYA
GDT
Q
NT
N
S
D
A
Y
TR
S
-
-KY
-----------------
G
D
E
T
N
R
L
YR
QNYALTWNGGWDN
G
V
TTSNWVQ
Y
EH
T
R
---------
N
---------
-
S
R
---
IPE
GL
A
G
GTE
GKFNEKA
T
QDFV
DIDL
D
DVMLH
SE
V
NL
PI
DFLVNQ
T
L
T
L
G
T
EW
NQQ
R
MK
D
LSSNTQA
L
TGANTG
G
AI
D
G
VSATDRSPYSKA
E
IF
SL
---
-
--
FAE
NNME
LTD
S
T
I
V
T
P
G
L
R
F
--------
DH
------------
HSIV
GN
----------
N
WSP
ALN
I
SQG
L
G
D
D
F
T
LK
M
G
IA
R
A
YKAP
S
L
Y
Q
TNPNYI
L
YSKGQ
G
CYA
--
SA
G
GCY
L
-----
Q
GN
D
DLK
A
E
T
S
I
N
K
EIG
LEF-KRD
G
W
L
A
G
VT
W
F
R
N
D
YR
NKI
E
A
GYVAVGQ
N
A
VGTDLYQ
W
D
N
V
P
KA
V
VE
G
L
E
G
S
LNV
P
-
VSE
T
VMWTN
N
I
T
Y
M
-------
LK
SE
N
KT
---
T
G
D
----
RLS
I
IPEY
T
L
N
S
T
L
S
W
QAR
E
DLSMQTTF
T
WY
GK
QQ
P
KKY
-
NY
KGQP
AV
-----
G
PE
T
KEISP
Y
S
I
VGL
SAT
W
D
V
T
K
---
N
V
S
L
TGG
VDNLFDK
-
-
---R
L
WRA
G
N
AQT
TGDL
AG
ANYIA
G
A
G
A
---
Y
T
Y
NE
PGR
TW
Y
MSVN
TH
F
fig|550672.3.peg.151
Escherichia coli B088 (47-746/746)
A
P
G
VS
T
I
TA
D
EIR
K
N
-
PVAR
D
V
SE
I
I
R
T
-
M
PGV
N
L
TGN
S
TS
G
QR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
K
P
VSSRNS
VRQG
WR
G
E
R
D
TR
G
----
D
T
SWV
PP
-
EM
IERIEVLRGP
A
A
A
R
YGN
G
A
A
GGVVNIITKKG
S
--------------
GE
W
HG
S
WD
A
YF
N
AP
E
HK
E
E
---
G
----
AT
K
RT
NF
SLT
GPL
-
G
D
EFSF
R
LY
G
NLD
K
TQ
A
D
A
WDINQ
--
GHQSARAGTYA
T
T
L
PAGR
E
GVI
N
K
D
I
N
G
VV
--
R
W
D
F
A
P
L
Q
S
L
EL
E
AGY
SRQ
GNLYA
GDT
Q
NT
N
S
D
A
Y
TR
S
-
-KY
-----------------
G
D
E
T
N
R
L
YR
QNYALTWNGGWDN
G
V
TTSNWVQ
Y
EH
T
R
---------
N
---------
-
S
R
---
IPE
GL
A
G
GTE
GKFNEKA
T
QDFV
DIDL
D
DVMLH
SE
V
NL
PI
DFLVNQ
T
L
T
L
G
T
EW
NQQ
R
MK
D
LSSNTQA
L
TGANTG
G
AI
D
G
VSATDRSPYSKA
E
IF
SL
---
-
--
FAE
NNME
LTD
S
T
I
V
T
P
G
L
R
F
--------
DH
------------
HSIV
GN
----------
N
WSP
ALN
I
SQG
L
G
D
D
F
T
LK
M
G
IA
R
A
YKAP
S
L
Y
Q
TNPNYI
L
YSKGQ
G
CYA
--
SA
G
GCY
L
-----
Q
GN
D
DLK
A
E
T
S
I
N
K
EIG
LEF-KRD
G
W
L
A
G
VT
W
F
R
N
D
YR
NKI
E
A
GYVAVGQ
N
A
VGTDLYQ
W
D
N
V
P
KA
V
VE
G
L
E
G
S
LNV
P
-
VSE
T
VMWTN
N
I
T
Y
M
-------
LK
SE
N
KT
---
T
G
D
----
RLS
I
IPEY
T
L
N
S
T
L
S
W
QAR
E
DLSMQTTF
T
WY
GK
QQ
P
KKY
-
NY
KGQP
AV
-----
G
PE
T
KEISP
Y
S
I
VGL
SAT
W
D
V
T
K
---
N
V
S
L
TGG
VDNLFDK
-
-
---R
L
WRA
G
N
AQT
TGDL
AG
ANYIA
G
A
G
A
---
Y
T
Y
NE
PGR
TW
Y
MSVN
TH
F
fig|340184.3.peg.2457
Escherichia coli B7A (47-746/746)
A
P
G
VS
T
I
TA
D
EIR
K
N
-
PVAR
D
V
SE
I
I
R
T
-
M
PGV
N
L
TGN
S
TS
G
QR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
K
P
VSSRNS
VRQG
WR
G
E
R
D
TR
G
----
D
T
SWV
PP
-
EM
IERIEVLRGP
A
A
A
R
YGN
G
A
A
GGVVNIITKKG
S
--------------
GE
W
HG
S
WD
A
YF
N
AP
E
HK
E
E
---
G
----
AT
K
RT
NF
SLT
GPL
-
G
D
EFSF
R
LY
G
NLD
K
TQ
A
D
A
WDINQ
--
GHQSARAGTYA
T
T
L
PAGR
E
GVI
N
K
D
I
N
G
VV
--
R
W
D
F
A
P
L
Q
S
L
EL
E
AGY
SRQ
GNLYA
GDT
Q
NT
N
S
D
A
Y
TR
S
-
-KY
-----------------
G
D
E
T
N
R
L
YR
QNYALTWNGGWDN
G
V
TTSNWVQ
Y
EH
T
R
---------
N
---------
-
S
R
---
IPE
GL
A
G
GTE
GKFNEKA
T
QDFV
DIDL
D
DVMLH
SE
V
NL
PI
DFLVNQ
T
L
T
L
G
T
EW
NQQ
R
MK
D
LSSNTQA
L
TGANTG
G
AI
D
G
VSATDRSPYSKA
E
IF
SL
---
-
--
FAE
NNME
LTD
S
T
I
V
T
P
G
L
R
F
--------
DH
------------
HSIV
GN
----------
N
WSP
ALN
I
SQG
L
G
D
D
F
T
LK
M
G
IA
R
A
YKAP
S
L
Y
Q
TNPNYI
L
YSKGQ
G
CYA
--
SA
G
GCY
L
-----
Q
GN
D
DLK
A
E
T
S
I
N
K
EIG
LEF-KRD
G
W
L
A
G
VT
W
F
R
N
D
YR
NKI
E
A
GYVAVGQ
N
A
VGTDLYQ
W
D
N
V
P
KA
V
VE
G
L
E
G
S
LNV
P
-
VSE
T
VMWTN
N
I
T
Y
M
-------
LK
SE
N
KT
---
T
G
D
----
RLS
I
IPEY
T
L
N
S
T
L
S
W
QAR
E
DLSMQTTF
T
WY
GK
QQ
P
KKY
-
NY
KGQP
AV
-----
G
PE
T
KEISP
Y
S
I
VGL
SAT
W
D
V
T
K
---
N
V
S
L
TGG
VDNLFDK
-
-
---R
L
WRA
G
N
AQT
TGDL
AG
ANYIA
G
A
G
A
---
Y
T
Y
NE
PGR
TW
Y
MSVN
TH
F
fig|340184.6.peg.2576
Escherichia coli B7A (47-746/746)
A
P
G
VS
T
I
TA
D
EIR
K
N
-
PVAR
D
V
SE
I
I
R
T
-
M
PGV
N
L
TGN
S
TS
G
QR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
K
P
VSSRNS
VRQG
WR
G
E
R
D
TR
G
----
D
T
SWV
PP
-
EM
IERIEVLRGP
A
A
A
R
YGN
G
A
A
GGVVNIITKKG
S
--------------
GE
W
HG
S
WD
A
YF
N
AP
E
HK
E
E
---
G
----
AT
K
RT
NF
SLT
GPL
-
G
D
EFSF
R
LY
G
NLD
K
TQ
A
D
A
WDINQ
--
GHQSARAGTYA
T
T
L
PAGR
E
GVI
N
K
D
I
N
G
VV
--
R
W
D
F
A
P
L
Q
S
L
EL
E
AGY
SRQ
GNLYA
GDT
Q
NT
N
S
D
A
Y
TR
S
-
-KY
-----------------
G
D
E
T
N
R
L
YR
QNYALTWNGGWDN
G
V
TTSNWVQ
Y
EH
T
R
---------
N
---------
-
S
R
---
IPE
GL
A
G
GTE
GKFNEKA
T
QDFV
DIDL
D
DVMLH
SE
V
NL
PI
DFLVNQ
T
L
T
L
G
T
EW
NQQ
R
MK
D
LSSNTQA
L
TGANTG
G
AI
D
G
VSATDRSPYSKA
E
IF
SL
---
-
--
FAE
NNME
LTD
S
T
I
V
T
P
G
L
R
F
--------
DH
------------
HSIV
GN
----------
N
WSP
ALN
I
SQG
L
G
D
D
F
T
LK
M
G
IA
R
A
YKAP
S
L
Y
Q
TNPNYI
L
YSKGQ
G
CYA
--
SA
G
GCY
L
-----
Q
GN
D
DLK
A
E
T
S
I
N
K
EIG
LEF-KRD
G
W
L
A
G
VT
W
F
R
N
D
YR
NKI
E
A
GYVAVGQ
N
A
VGTDLYQ
W
D
N
V
P
KA
V
VE
G
L
E
G
S
LNV
P
-
VSE
T
VMWTN
N
I
T
Y
M
-------
LK
SE
N
KT
---
T
G
D
----
RLS
I
IPEY
T
L
N
S
T
L
S
W
QAR
E
DLSMQTTF
T
WY
GK
QQ
P
KKY
-
NY
KGQP
AV
-----
G
PE
T
KEISP
Y
S
I
VGL
SAT
W
D
V
T
K
---
N
V
S
L
TGG
VDNLFDK
-
-
---R
L
WRA
G
N
AQT
TGDL
AG
ANYIA
G
A
G
A
---
Y
T
Y
NE
PGR
TW
Y
MSVN
TH
F
fig|340186.3.peg.2236
Escherichia coli E110019 (47-746/746)
A
P
G
VS
T
I
TA
D
EIR
K
N
-
PVAR
D
V
SE
I
I
R
T
-
M
PGV
N
L
TGN
S
TS
G
QR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
K
P
VSSRNS
VRQG
WR
G
E
R
D
TR
G
----
D
T
SWV
PP
-
EM
IERIEVLRGP
A
A
A
R
YGN
G
A
A
GGVVNIITKKG
S
--------------
GE
W
HG
S
WD
A
YF
N
AP
E
HK
E
E
---
G
----
AT
K
RT
NF
SLT
GPL
-
G
D
EFSF
R
LY
G
NLD
K
TQ
A
D
A
WDINQ
--
GHQSARAGTYA
T
T
L
PAGR
E
GVI
N
K
D
I
N
G
VV
--
R
W
D
F
A
P
L
Q
S
L
EL
E
AGY
SRQ
GNLYA
GDT
Q
NT
N
S
D
A
Y
TR
S
-
-KY
-----------------
G
D
E
T
N
R
L
YR
QNYALTWNGGWDN
G
V
TTSNWVQ
Y
EH
T
R
---------
N
---------
-
S
R
---
IPE
GL
A
G
GTE
GKFNEKA
T
QDFV
DIDL
D
DVMLH
SE
V
NL
PI
DFLVNQ
T
L
T
L
G
T
EW
NQQ
R
MK
D
LSSNTQA
L
TGANTG
G
AI
D
G
VSATDRSPYSKA
E
IF
SL
---
-
--
FAE
NNME
LTD
S
T
I
V
T
P
G
L
R
F
--------
DH
------------
HSIV
GN
----------
N
WSP
ALN
I
SQG
L
G
D
D
F
T
LK
M
G
IA
R
A
YKAP
S
L
Y
Q
TNPNYI
L
YSKGQ
G
CYA
--
SA
G
GCY
L
-----
Q
GN
D
DLK
A
E
T
S
I
N
K
EIG
LEF-KRD
G
W
L
A
G
VT
W
F
R
N
D
YR
NKI
E
A
GYVAVGQ
N
A
VGTDLYQ
W
D
N
V
P
KA
V
VE
G
L
E
G
S
LNV
P
-
VSE
T
VMWTN
N
I
T
Y
M
-------
LK
SE
N
KT
---
T
G
D
----
RLS
I
IPEY
T
L
N
S
T
L
S
W
QAR
E
DLSMQTTF
T
WY
GK
QQ
P
KKY
-
NY
KGQP
AV
-----
G
PE
T
KEISP
Y
S
I
VGL
SAT
W
D
V
T
K
---
N
V
S
L
TGG
VDNLFDK
-
-
---R
L
WRA
G
N
AQT
TGDL
AG
ANYIA
G
A
G
A
---
Y
T
Y
NE
PGR
TW
Y
MSVN
TH
F
fig|340186.5.peg.2310
Escherichia coli E110019 (47-746/746)
A
P
G
VS
T
I
TA
D
EIR
K
N
-
PVAR
D
V
SE
I
I
R
T
-
M
PGV
N
L
TGN
S
TS
G
QR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
K
P
VSSRNS
VRQG
WR
G
E
R
D
TR
G
----
D
T
SWV
PP
-
EM
IERIEVLRGP
A
A
A
R
YGN
G
A
A
GGVVNIITKKG
S
--------------
GE
W
HG
S
WD
A
YF
N
AP
E
HK
E
E
---
G
----
AT
K
RT
NF
SLT
GPL
-
G
D
EFSF
R
LY
G
NLD
K
TQ
A
D
A
WDINQ
--
GHQSARAGTYA
T
T
L
PAGR
E
GVI
N
K
D
I
N
G
VV
--
R
W
D
F
A
P
L
Q
S
L
EL
E
AGY
SRQ
GNLYA
GDT
Q
NT
N
S
D
A
Y
TR
S
-
-KY
-----------------
G
D
E
T
N
R
L
YR
QNYALTWNGGWDN
G
V
TTSNWVQ
Y
EH
T
R
---------
N
---------
-
S
R
---
IPE
GL
A
G
GTE
GKFNEKA
T
QDFV
DIDL
D
DVMLH
SE
V
NL
PI
DFLVNQ
T
L
T
L
G
T
EW
NQQ
R
MK
D
LSSNTQA
L
TGANTG
G
AI
D
G
VSATDRSPYSKA
E
IF
SL
---
-
--
FAE
NNME
LTD
S
T
I
V
T
P
G
L
R
F
--------
DH
------------
HSIV
GN
----------
N
WSP
ALN
I
SQG
L
G
D
D
F
T
LK
M
G
IA
R
A
YKAP
S
L
Y
Q
TNPNYI
L
YSKGQ
G
CYA
--
SA
G
GCY
L
-----
Q
GN
D
DLK
A
E
T
S
I
N
K
EIG
LEF-KRD
G
W
L
A
G
VT
W
F
R
N
D
YR
NKI
E
A
GYVAVGQ
N
A
VGTDLYQ
W
D
N
V
P
KA
V
VE
G
L
E
G
S
LNV
P
-
VSE
T
VMWTN
N
I
T
Y
M
-------
LK
SE
N
KT
---
T
G
D
----
RLS
I
IPEY
T
L
N
S
T
L
S
W
QAR
E
DLSMQTTF
T
WY
GK
QQ
P
KKY
-
NY
KGQP
AV
-----
G
PE
T
KEISP
Y
S
I
VGL
SAT
W
D
V
T
K
---
N
V
S
L
TGG
VDNLFDK
-
-
---R
L
WRA
G
N
AQT
TGDL
AG
ANYIA
G
A
G
A
---
Y
T
Y
NE
PGR
TW
Y
MSVN
TH
F
fig|562.375.peg.1576
Escherichia coli EC4100B (47-746/746)
A
P
G
VS
T
I
TA
D
EIR
K
N
-
PVAR
D
V
SE
I
I
R
T
-
M
PGV
N
L
TGN
S
TS
G
QR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
K
P
VSSRNS
VRQG
WR
G
E
R
D
TR
G
----
D
T
SWV
PP
-
EM
IERIEVLRGP
A
A
A
R
YGN
G
A
A
GGVVNIITKKG
S
--------------
GE
W
HG
S
WD
A
YF
N
AP
E
HK
E
E
---
G
----
AT
K
RT
NF
SLT
GPL
-
G
D
EFSF
R
LY
G
NLD
K
TQ
A
D
A
WDINQ
--
GHQSARAGTYA
T
T
L
PAGR
E
GVI
N
K
D
I
N
G
VV
--
R
W
D
F
A
P
L
Q
S
L
EL
E
AGY
SRQ
GNLYA
GDT
Q
NT
N
S
D
A
Y
TR
S
-
-KY
-----------------
G
D
E
T
N
R
L
YR
QNYALTWNGGWDN
G
V
TTSNWVQ
Y
EH
T
R
---------
N
---------
-
S
R
---
IPE
GL
A
G
GTE
GKFNEKA
T
QDFV
DIDL
D
DVMLH
SE
V
NL
PI
DFLVNQ
T
L
T
L
G
T
EW
NQQ
R
MK
D
LSSNTQA
L
TGANTG
G
AI
D
G
VSATDRSPYSKA
E
IF
SL
---
-
--
FAE
NNME
LTD
S
T
I
V
T
P
G
L
R
F
--------
DH
------------
HSIV
GN
----------
N
WSP
ALN
I
SQG
L
G
D
D
F
T
LK
M
G
IA
R
A
YKAP
S
L
Y
Q
TNPNYI
L
YSKGQ
G
CYA
--
SA
G
GCY
L
-----
Q
GN
D
DLK
A
E
T
S
I
N
K
EIG
LEF-KRD
G
W
L
A
G
VT
W
F
R
N
D
YR
NKI
E
A
GYVAVGQ
N
A
VGTDLYQ
W
D
N
V
P
KA
V
VE
G
L
E
G
S
LNV
P
-
VSE
T
VMWTN
N
I
T
Y
M
-------
LK
SE
N
KT
---
T
G
D
----
RLS
I
IPEY
T
L
N
S
T
L
S
W
QAR
E
DLSMQTTF
T
WY
GK
QQ
P
KKY
-
NY
KGQP
AV
-----
G
PE
T
KEISP
Y
S
I
VGL
SAT
W
D
V
T
K
---
N
V
S
L
TGG
VDNLFDK
-
-
---R
L
WRA
G
N
AQT
TGDL
AG
ANYIA
G
A
G
A
---
Y
T
Y
NE
PGR
TW
Y
MSVN
TH
F
fig|585034.4.peg.560
Escherichia coli IAI1 (47-746/746)
A
P
G
VS
T
I
TA
D
EIR
K
N
-
PVAR
D
V
SE
I
I
R
T
-
M
PGV
N
L
TGN
S
TS
G
QR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
K
P
VSSRNS
VRQG
WR
G
E
R
D
TR
G
----
D
T
SWV
PP
-
EM
IERIEVLRGP
A
A
A
R
YGN
G
A
A
GGVVNIITKKG
S
--------------
GE
W
HG
S
WD
A
YF
N
AP
E
HK
E
E
---
G
----
AT
K
RT
NF
SLT
GPL
-
G
D
EFSF
R
LY
G
NLD
K
TQ
A
D
A
WDINQ
--
GHQSARAGTYA
T
T
L
PAGR
E
GVI
N
K
D
I
N
G
VV
--
R
W
D
F
A
P
L
Q
S
L
EL
E
AGY
SRQ
GNLYA
GDT
Q
NT
N
S
D
A
Y
TR
S
-
-KY
-----------------
G
D
E
T
N
R
L
YR
QNYALTWNGGWDN
G
V
TTSNWVQ
Y
EH
T
R
---------
N
---------
-
S
R
---
IPE
GL
A
G
GTE
GKFNEKA
T
QDFV
DIDL
D
DVMLH
SE
V
NL
PI
DFLVNQ
T
L
T
L
G
T
EW
NQQ
R
MK
D
LSSNTQA
L
TGANTG
G
AI
D
G
VSATDRSPYSKA
E
IF
SL
---
-
--
FAE
NNME
LTD
S
T
I
V
T
P
G
L
R
F
--------
DH
------------
HSIV
GN
----------
N
WSP
ALN
I
SQG
L
G
D
D
F
T
LK
M
G
IA
R
A
YKAP
S
L
Y
Q
TNPNYI
L
YSKGQ
G
CYA
--
SA
G
GCY
L
-----
Q
GN
D
DLK
A
E
T
S
I
N
K
EIG
LEF-KRD
G
W
L
A
G
VT
W
F
R
N
D
YR
NKI
E
A
GYVAVGQ
N
A
VGTDLYQ
W
D
N
V
P
KA
V
VE
G
L
E
G
S
LNV
P
-
VSE
T
VMWTN
N
I
T
Y
M
-------
LK
SE
N
KT
---
T
G
D
----
RLS
I
IPEY
T
L
N
S
T
L
S
W
QAR
E
DLSMQTTF
T
WY
GK
QQ
P
KKY
-
NY
KGQP
AV
-----
G
PE
T
KEISP
Y
S
I
VGL
SAT
W
D
V
T
K
---
N
V
S
L
TGG
VDNLFDK
-
-
---R
L
WRA
G
N
AQT
TGDL
AG
ANYIA
G
A
G
A
---
Y
T
Y
NE
PGR
TW
Y
MSVN
TH
F
fig|585034.5.peg.559
Escherichia coli IAI1 (47-746/746)
A
P
G
VS
T
I
TA
D
EIR
K
N
-
PVAR
D
V
SE
I
I
R
T
-
M
PGV
N
L
TGN
S
TS
G
QR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
K
P
VSSRNS
VRQG
WR
G
E
R
D
TR
G
----
D
T
SWV
PP
-
EM
IERIEVLRGP
A
A
A
R
YGN
G
A
A
GGVVNIITKKG
S
--------------
GE
W
HG
S
WD
A
YF
N
AP
E
HK
E
E
---
G
----
AT
K
RT
NF
SLT
GPL
-
G
D
EFSF
R
LY
G
NLD
K
TQ
A
D
A
WDINQ
--
GHQSARAGTYA
T
T
L
PAGR
E
GVI
N
K
D
I
N
G
VV
--
R
W
D
F
A
P
L
Q
S
L
EL
E
AGY
SRQ
GNLYA
GDT
Q
NT
N
S
D
A
Y
TR
S
-
-KY
-----------------
G
D
E
T
N
R
L
YR
QNYALTWNGGWDN
G
V
TTSNWVQ
Y
EH
T
R
---------
N
---------
-
S
R
---
IPE
GL
A
G
GTE
GKFNEKA
T
QDFV
DIDL
D
DVMLH
SE
V
NL
PI
DFLVNQ
T
L
T
L
G
T
EW
NQQ
R
MK
D
LSSNTQA
L
TGANTG
G
AI
D
G
VSATDRSPYSKA
E
IF
SL
---
-
--
FAE
NNME
LTD
S
T
I
V
T
P
G
L
R
F
--------
DH
------------
HSIV
GN
----------
N
WSP
ALN
I
SQG
L
G
D
D
F
T
LK
M
G
IA
R
A
YKAP
S
L
Y
Q
TNPNYI
L
YSKGQ
G
CYA
--
SA
G
GCY
L
-----
Q
GN
D
DLK
A
E
T
S
I
N
K
EIG
LEF-KRD
G
W
L
A
G
VT
W
F
R
N
D
YR
NKI
E
A
GYVAVGQ
N
A
VGTDLYQ
W
D
N
V
P
KA
V
VE
G
L
E
G
S
LNV
P
-
VSE
T
VMWTN
N
I
T
Y
M
-------
LK
SE
N
KT
---
T
G
D
----
RLS
I
IPEY
T
L
N
S
T
L
S
W
QAR
E
DLSMQTTF
T
WY
GK
QQ
P
KKY
-
NY
KGQP
AV
-----
G
PE
T
KEISP
Y
S
I
VGL
SAT
W
D
V
T
K
---
N
V
S
L
TGG
VDNLFDK
-
-
---R
L
WRA
G
N
AQT
TGDL
AG
ANYIA
G
A
G
A
---
Y
T
Y
NE
PGR
TW
Y
MSVN
TH
F
fig|595495.4.peg.2033
Escherichia coli KO11 (47-746/746)
A
P
G
VS
T
I
TA
D
EIR
K
N
-
PVAR
D
V
SE
I
I
R
T
-
M
PGV
N
L
TGN
S
TS
G
QR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
K
P
VSSRNS
VRQG
WR
G
E
R
D
TR
G
----
D
T
SWV
PP
-
EM
IERIEVLRGP
A
A
A
R
YGN
G
A
A
GGVVNIITKKG
S
--------------
GE
W
HG
S
WD
A
YF
N
AP
E
HK
E
E
---
G
----
AT
K
RT
NF
SLT
GPL
-
G
D
EFSF
R
LY
G
NLD
K
TQ
A
D
A
WDINQ
--
GHQSARAGTYA
T
T
L
PAGR
E
GVI
N
K
D
I
N
G
VV
--
R
W
D
F
A
P
L
Q
S
L
EL
E
AGY
SRQ
GNLYA
GDT
Q
NT
N
S
D
A
Y
TR
S
-
-KY
-----------------
G
D
E
T
N
R
L
YR
QNYALTWNGGWDN
G
V
TTSNWVQ
Y
EH
T
R
---------
N
---------
-
S
R
---
IPE
GL
A
G
GTE
GKFNEKA
T
QDFV
DIDL
D
DVMLH
SE
V
NL
PI
DFLVNQ
T
L
T
L
G
T
EW
NQQ
R
MK
D
LSSNTQA
L
TGANTG
G
AI
D
G
VSATDRSPYSKA
E
IF
SL
---
-
--
FAE
NNME
LTD
S
T
I
V
T
P
G
L
R
F
--------
DH
------------
HSIV
GN
----------
N
WSP
ALN
I
SQG
L
G
D
D
F
T
LK
M
G
IA
R
A
YKAP
S
L
Y
Q
TNPNYI
L
YSKGQ
G
CYA
--
SA
G
GCY
L
-----
Q
GN
D
DLK
A
E
T
S
I
N
K
EIG
LEF-KRD
G
W
L
A
G
VT
W
F
R
N
D
YR
NKI
E
A
GYVAVGQ
N
A
VGTDLYQ
W
D
N
V
P
KA
V
VE
G
L
E
G
S
LNV
P
-
VSE
T
VMWTN
N
I
T
Y
M
-------
LK
SE
N
KT
---
T
G
D
----
RLS
I
IPEY
T
L
N
S
T
L
S
W
QAR
E
DLSMQTTF
T
WY
GK
QQ
P
KKY
-
NY
KGQP
AV
-----
G
PE
T
KEISP
Y
S
I
VGL
SAT
W
D
V
T
K
---
N
V
S
L
TGG
VDNLFDK
-
-
---R
L
WRA
G
N
AQT
TGDL
AG
ANYIA
G
A
G
A
---
Y
T
Y
NE
PGR
TW
Y
MSVN
TH
F
fig|679206.4.peg.2887
Escherichia coli MS 119-7 (47-746/746)
A
P
G
VS
T
I
TA
D
EIR
K
N
-
PVAR
D
V
SE
I
I
R
T
-
M
PGV
N
L
TGN
S
TS
G
QR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
K
P
VSSRNS
VRQG
WR
G
E
R
D
TR
G
----
D
T
SWV
PP
-
EM
IERIEVLRGP
A
A
A
R
YGN
G
A
A
GGVVNIITKKG
S
--------------
GE
W
HG
S
WD
A
YF
N
AP
E
HK
E
E
---
G
----
AT
K
RT
NF
SLT
GPL
-
G
D
EFSF
R
LY
G
NLD
K
TQ
A
D
A
WDINQ
--
GHQSARAGTYA
T
T
L
PAGR
E
GVI
N
K
D
I
N
G
VV
--
R
W
D
F
A
P
L
Q
S
L
EL
E
AGY
SRQ
GNLYA
GDT
Q
NT
N
S
D
A
Y
TR
S
-
-KY
-----------------
G
D
E
T
N
R
L
YR
QNYALTWNGGWDN
G
V
TTSNWVQ
Y
EH
T
R
---------
N
---------
-
S
R
---
IPE
GL
A
G
GTE
GKFNEKA
T
QDFV
DIDL
D
DVMLH
SE
V
NL
PI
DFLVNQ
T
L
T
L
G
T
EW
NQQ
R
MK
D
LSSNTQA
L
TGANTG
G
AI
D
G
VSATDRSPYSKA
E
IF
SL
---
-
--
FAE
NNME
LTD
S
T
I
V
T
P
G
L
R
F
--------
DH
------------
HSIV
GN
----------
N
WSP
ALN
I
SQG
L
G
D
D
F
T
LK
M
G
IA
R
A
YKAP
S
L
Y
Q
TNPNYI
L
YSKGQ
G
CYA
--
SA
G
GCY
L
-----
Q
GN
D
DLK
A
E
T
S
I
N
K
EIG
LEF-KRD
G
W
L
A
G
VT
W
F
R
N
D
YR
NKI
E
A
GYVAVGQ
N
A
VGTDLYQ
W
D
N
V
P
KA
V
VE
G
L
E
G
S
LNV
P
-
VSE
T
VMWTN
N
I
T
Y
M
-------
LK
SE
N
KT
---
T
G
D
----
RLS
I
IPEY
T
L
N
S
T
L
S
W
QAR
E
DLSMQTTF
T
WY
GK
QQ
P
KKY
-
NY
KGQP
AV
-----
G
PE
T
KEISP
Y
S
I
VGL
SAT
W
D
V
T
K
---
N
V
S
L
TGG
VDNLFDK
-
-
---R
L
WRA
G
N
AQT
TGDL
AG
ANYIA
G
A
G
A
---
Y
T
Y
NE
PGR
TW
Y
MSVN
TH
F
fig|749545.3.peg.4920
Escherichia coli MS 182-1 (47-746/746)
A
P
G
VS
T
I
TA
D
EIR
K
N
-
PVAR
D
V
SE
I
I
R
T
-
M
PGV
N
L
TGN
S
TS
G
QR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
K
P
VSSRNS
VRQG
WR
G
E
R
D
TR
G
----
D
T
SWV
PP
-
EM
IERIEVLRGP
A
A
A
R
YGN
G
A
A
GGVVNIITKKG
S
--------------
GE
W
HG
S
WD
A
YF
N
AP
E
HK
E
E
---
G
----
AT
K
RT
NF
SLT
GPL
-
G
D
EFSF
R
LY
G
NLD
K
TQ
A
D
A
WDINQ
--
GHQSARAGTYA
T
T
L
PAGR
E
GVI
N
K
D
I
N
G
VV
--
R
W
D
F
A
P
L
Q
S
L
EL
E
AGY
SRQ
GNLYA
GDT
Q
NT
N
S
D
A
Y
TR
S
-
-KY
-----------------
G
D
E
T
N
R
L
YR
QNYALTWNGGWDN
G
V
TTSNWVQ
Y
EH
T
R
---------
N
---------
-
S
R
---
IPE
GL
A
G
GTE
GKFNEKA
T
QDFV
DIDL
D
DVMLH
SE
V
NL
PI
DFLVNQ
T
L
T
L
G
T
EW
NQQ
R
MK
D
LSSNTQA
L
TGANTG
G
AI
D
G
VSATDRSPYSKA
E
IF
SL
---
-
--
FAE
NNME
LTD
S
T
I
V
T
P
G
L
R
F
--------
DH
------------
HSIV
GN
----------
N
WSP
ALN
I
SQG
L
G
D
D
F
T
LK
M
G
IA
R
A
YKAP
S
L
Y
Q
TNPNYI
L
YSKGQ
G
CYA
--
SA
G
GCY
L
-----
Q
GN
D
DLK
A
E
T
S
I
N
K
EIG
LEF-KRD
G
W
L
A
G
VT
W
F
R
N
D
YR
NKI
E
A
GYVAVGQ
N
A
VGTDLYQ
W
D
N
V
P
KA
V
VE
G
L
E
G
S
LNV
P
-
VSE
T
VMWTN
N
I
T
Y
M
-------
LK
SE
N
KT
---
T
G
D
----
RLS
I
IPEY
T
L
N
S
T
L
S
W
QAR
E
DLSMQTTF
T
WY
GK
QQ
P
KKY
-
NY
KGQP
AV
-----
G
PE
T
KEISP
Y
S
I
VGL
SAT
W
D
V
T
K
---
N
V
S
L
TGG
VDNLFDK
-
-
---R
L
WRA
G
N
AQT
TGDL
AG
ANYIA
G
A
G
A
---
Y
T
Y
NE
PGR
TW
Y
MSVN
TH
F
fig|749532.3.peg.3655
Escherichia coli MS 78-1 (47-746/746)
A
P
G
VS
T
I
TA
D
EIR
K
N
-
PVAR
D
V
SE
I
I
R
T
-
M
PGV
N
L
TGN
S
TS
G
QR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
K
P
VSSRNS
VRQG
WR
G
E
R
D
TR
G
----
D
T
SWV
PP
-
EM
IERIEVLRGP
A
A
A
R
YGN
G
A
A
GGVVNIITKKG
S
--------------
GE
W
HG
S
WD
A
YF
N
AP
E
HK
E
E
---
G
----
AT
K
RT
NF
SLT
GPL
-
G
D
EFSF
R
LY
G
NLD
K
TQ
A
D
A
WDINQ
--
GHQSARAGTYA
T
T
L
PAGR
E
GVI
N
K
D
I
N
G
VV
--
R
W
D
F
A
P
L
Q
S
L
EL
E
AGY
SRQ
GNLYA
GDT
Q
NT
N
S
D
A
Y
TR
S
-
-KY
-----------------
G
D
E
T
N
R
L
YR
QNYALTWNGGWDN
G
V
TTSNWVQ
Y
EH
T
R
---------
N
---------
-
S
R
---
IPE
GL
A
G
GTE
GKFNEKA
T
QDFV
DIDL
D
DVMLH
SE
V
NL
PI
DFLVNQ
T
L
T
L
G
T
EW
NQQ
R
MK
D
LSSNTQA
L
TGANTG
G
AI
D
G
VSATDRSPYSKA
E
IF
SL
---
-
--
FAE
NNME
LTD
S
T
I
V
T
P
G
L
R
F
--------
DH
------------
HSIV
GN
----------
N
WSP
ALN
I
SQG
L
G
D
D
F
T
LK
M
G
IA
R
A
YKAP
S
L
Y
Q
TNPNYI
L
YSKGQ
G
CYA
--
SA
G
GCY
L
-----
Q
GN
D
DLK
A
E
T
S
I
N
K
EIG
LEF-KRD
G
W
L
A
G
VT
W
F
R
N
D
YR
NKI
E
A
GYVAVGQ
N
A
VGTDLYQ
W
D
N
V
P
KA
V
VE
G
L
E
G
S
LNV
P
-
VSE
T
VMWTN
N
I
T
Y
M
-------
LK
SE
N
KT
---
T
G
D
----
RLS
I
IPEY
T
L
N
S
T
L
S
W
QAR
E
DLSMQTTF
T
WY
GK
QQ
P
KKY
-
NY
KGQP
AV
-----
G
PE
T
KEISP
Y
S
I
VGL
SAT
W
D
V
T
K
---
N
V
S
L
TGG
VDNLFDK
-
-
---R
L
WRA
G
N
AQT
TGDL
AG
ANYIA
G
A
G
A
---
Y
T
Y
NE
PGR
TW
Y
MSVN
TH
F
fig|585396.4.peg.635
Escherichia coli O111:H- str. 11128 (47-746/746)
A
P
G
VS
T
I
TA
D
EIR
K
N
-
PVAR
D
V
SE
I
I
R
T
-
M
PGV
N
L
TGN
S
TS
G
QR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
K
P
VSSRNS
VRQG
WR
G
E
R
D
TR
G
----
D
T
SWV
PP
-
EM
IERIEVLRGP
A
A
A
R
YGN
G
A
A
GGVVNIITKKG
S
--------------
GE
W
HG
S
WD
A
YF
N
AP
E
HK
E
E
---
G
----
AT
K
RT
NF
SLT
GPL
-
G
D
EFSF
R
LY
G
NLD
K
TQ
A
D
A
WDINQ
--
GHQSARAGTYA
T
T
L
PAGR
E
GVI
N
K
D
I
N
G
VV
--
R
W
D
F
A
P
L
Q
S
L
EL
E
AGY
SRQ
GNLYA
GDT
Q
NT
N
S
D
A
Y
TR
S
-
-KY
-----------------
G
D
E
T
N
R
L
YR
QNYALTWNGGWDN
G
V
TTSNWVQ
Y
EH
T
R
---------
N
---------
-
S
R
---
IPE
GL
A
G
GTE
GKFNEKA
T
QDFV
DIDL
D
DVMLH
SE
V
NL
PI
DFLVNQ
T
L
T
L
G
T
EW
NQQ
R
MK
D
LSSNTQA
L
TGANTG
G
AI
D
G
VSATDRSPYSKA
E
IF
SL
---
-
--
FAE
NNME
LTD
S
T
I
V
T
P
G
L
R
F
--------
DH
------------
HSIV
GN
----------
N
WSP
ALN
I
SQG
L
G
D
D
F
T
LK
M
G
IA
R
A
YKAP
S
L
Y
Q
TNPNYI
L
YSKGQ
G
CYA
--
SA
G
GCY
L
-----
Q
GN
D
DLK
A
E
T
S
I
N
K
EIG
LEF-KRD
G
W
L
A
G
VT
W
F
R
N
D
YR
NKI
E
A
GYVAVGQ
N
A
VGTDLYQ
W
D
N
V
P
KA
V
VE
G
L
E
G
S
LNV
P
-
VSE
T
VMWTN
N
I
T
Y
M
-------
LK
SE
N
KT
---
T
G
D
----
RLS
I
IPEY
T
L
N
S
T
L
S
W
QAR
E
DLSMQTTF
T
WY
GK
QQ
P
KKY
-
NY
KGQP
AV
-----
G
PE
T
KEISP
Y
S
I
VGL
SAT
W
D
V
T
K
---
N
V
S
L
TGG
VDNLFDK
-
-
---R
L
WRA
G
N
AQT
TGDL
AG
ANYIA
G
A
G
A
---
Y
T
Y
NE
PGR
TW
Y
MSVN
TH
F
fig|573235.3.peg.664
Escherichia coli O26:H11 str. 11368 (47-746/746)
A
P
G
VS
T
I
TA
D
EIR
K
N
-
PVAR
D
V
SE
I
I
R
T
-
M
PGV
N
L
TGN
S
TS
G
QR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
K
P
VSSRNS
VRQG
WR
G
E
R
D
TR
G
----
D
T
SWV
PP
-
EM
IERIEVLRGP
A
A
A
R
YGN
G
A
A
GGVVNIITKKG
S
--------------
GE
W
HG
S
WD
A
YF
N
AP
E
HK
E
E
---
G
----
AT
K
RT
NF
SLT
GPL
-
G
D
EFSF
R
LY
G
NLD
K
TQ
A
D
A
WDINQ
--
GHQSARAGTYA
T
T
L
PAGR
E
GVI
N
K
D
I
N
G
VV
--
R
W
D
F
A
P
L
Q
S
L
EL
E
AGY
SRQ
GNLYA
GDT
Q
NT
N
S
D
A
Y
TR
S
-
-KY
-----------------
G
D
E
T
N
R
L
YR
QNYALTWNGGWDN
G
V
TTSNWVQ
Y
EH
T
R
---------
N
---------
-
S
R
---
IPE
GL
A
G
GTE
GKFNEKA
T
QDFV
DIDL
D
DVMLH
SE
V
NL
PI
DILVNQ
T
L
T
L
G
T
EW
NQQ
R
MK
D
LSSNTQA
L
TGANTG
G
AI
D
G
MSATDRSPYSKA
E
IF
SL
---
-
--
FAE
NNME
LTD
S
T
I
V
T
P
G
L
R
F
--------
DH
------------
HSIV
GN
----------
N
WSP
ALN
I
SQG
L
G
D
D
F
T
LK
M
G
IA
R
A
YKAP
S
L
Y
Q
TNPNYI
L
YSKGQ
G
CYA
--
SA
G
GCY
L
-----
Q
GN
D
DLK
A
E
T
S
I
N
K
EIG
LEF-KRD
G
W
L
A
G
VT
W
F
R
N
D
YR
NKI
E
A
GYVAVGQ
N
A
VGTDLYQ
W
D
N
V
P
KA
V
VE
G
L
E
G
S
LNV
P
-
VSE
T
VMWTN
N
I
T
Y
M
-------
LK
SE
N
KT
---
T
G
D
----
RLS
I
IPEY
T
L
N
S
T
L
S
W
QAR
E
DLSMQTTF
T
WY
GK
QQ
P
KKY
-
NY
KGQP
AV
-----
G
PE
T
KEISP
Y
S
I
VGL
SAT
W
D
V
T
K
---
N
V
S
L
TGG
VDNLFDK
-
-
---R
L
WRA
G
N
AQT
TGDL
AG
ANYIA
G
A
G
A
---
Y
T
Y
NE
PGR
TW
Y
MSVN
TH
F
fig|656443.3.peg.838
Escherichia coli TA271 (47-746/746)
A
P
G
VS
T
I
TA
D
EIR
K
N
-
PVAR
D
V
SE
I
I
R
T
-
M
PGV
N
L
TGN
S
TS
G
QR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
K
P
VSSRNS
VRQG
WR
G
E
R
D
TR
G
----
D
T
SWV
PP
-
EM
IERIEVLRGP
A
A
A
R
YGN
G
A
A
GGVVNIITKKG
S
--------------
GE
W
HG
S
WD
A
YF
N
AP
E
HK
E
E
---
G
----
AT
K
RT
NF
SLT
GPL
-
G
D
EFSF
R
LY
G
NLD
K
TQ
A
D
A
WDINQ
--
GHQSARAGTYA
T
T
L
PAGR
E
GVI
N
K
D
I
N
G
VV
--
R
W
D
F
A
P
L
Q
S
L
EL
E
AGY
SRQ
GNLYA
GDT
Q
NT
N
S
D
A
Y
TR
S
-
-KY
-----------------
G
D
E
T
N
R
L
YR
QNYALTWNGGWDN
G
V
TTSNWVQ
Y
EH
T
R
---------
N
---------
-
S
R
---
IPE
GL
A
G
GTE
GKFNEKA
T
QDFV
DIDL
D
DVMLH
SE
V
NL
PI
DFLVNQ
T
L
T
L
G
T
EW
NQQ
R
MK
D
LSSNTQA
L
TGANTG
G
AI
D
G
VSATDRSPYSKA
E
IF
SL
---
-
--
FAE
NNME
LTD
S
T
I
V
T
P
G
L
R
F
--------
DH
------------
HSIV
GN
----------
N
WSP
ALN
I
SQG
L
G
D
D
F
T
LK
M
G
IA
R
A
YKAP
S
L
Y
Q
TNPNYI
L
YSKGQ
G
CYA
--
SA
G
GCY
L
-----
Q
GN
D
DLK
A
E
T
S
I
N
K
EIG
LEF-KRD
G
W
L
A
G
VT
W
F
R
N
D
YR
NKI
E
A
GYVAVGQ
N
A
VGTDLYQ
W
D
N
V
P
KA
V
VE
G
L
E
G
S
LNV
P
-
VSE
T
VMWTN
N
I
T
Y
M
-------
LK
SE
N
KT
---
T
G
D
----
RLS
I
IPEY
T
L
N
S
T
L
S
W
QAR
E
DLSMQTTF
T
WY
GK
QQ
P
KKY
-
NY
KGQP
AV
-----
G
PE
T
KEISP
Y
S
I
VGL
SAT
W
D
V
T
K
---
N
V
S
L
TGG
VDNLFDK
-
-
---R
L
WRA
G
N
AQT
TGDL
AG
ANYIA
G
A
G
A
---
Y
T
Y
NE
PGR
TW
Y
MSVN
TH
F
fig|566546.3.peg.2868
Escherichia coli W (47-746/746)
A
P
G
VS
T
I
TA
D
EIR
K
N
-
PVAR
D
V
SE
I
I
R
T
-
M
PGV
N
L
TGN
S
TS
G
QR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
K
P
VSSRNS
VRQG
WR
G
E
R
D
TR
G
----
D
T
SWV
PP
-
EM
IERIEVLRGP
A
A
A
R
YGN
G
A
A
GGVVNIITKKG
S
--------------
GE
W
HG
S
WD
A
YF
N
AP
E
HK
E
E
---
G
----
AT
K
RT
NF
SLT
GPL
-
G
D
EFSF
R
LY
G
NLD
K
TQ
A
D
A
WDINQ
--
GHQSARAGTYA
T
T
L
PAGR
E
GVI
N
K
D
I
N
G
VV
--
R
W
D
F
A
P
L
Q
S
L
EL
E
AGY
SRQ
GNLYA
GDT
Q
NT
N
S
D
A
Y
TR
S
-
-KY
-----------------
G
D
E
T
N
R
L
YR
QNYALTWNGGWDN
G
V
TTSNWVQ
Y
EH
T
R
---------
N
---------
-
S
R
---
IPE
GL
A
G
GTE
GKFNEKA
T
QDFV
DIDL
D
DVMLH
SE
V
NL
PI
DFLVNQ
T
L
T
L
G
T
EW
NQQ
R
MK
D
LSSNTQA
L
TGANTG
G
AI
D
G
VSATDRSPYSKA
E
IF
SL
---
-
--
FAE
NNME
LTD
S
T
I
V
T
P
G
L
R
F
--------
DH
------------
HSIV
GN
----------
N
WSP
ALN
I
SQG
L
G
D
D
F
T
LK
M
G
IA
R
A
YKAP
S
L
Y
Q
TNPNYI
L
YSKGQ
G
CYA
--
SA
G
GCY
L
-----
Q
GN
D
DLK
A
E
T
S
I
N
K
EIG
LEF-KRD
G
W
L
A
G
VT
W
F
R
N
D
YR
NKI
E
A
GYVAVGQ
N
A
VGTDLYQ
W
D
N
V
P
KA
V
VE
G
L
E
G
S
LNV
P
-
VSE
T
VMWTN
N
I
T
Y
M
-------
LK
SE
N
KT
---
T
G
D
----
RLS
I
IPEY
T
L
N
S
T
L
S
W
QAR
E
DLSMQTTF
T
WY
GK
QQ
P
KKY
-
NY
KGQP
AV
-----
G
PE
T
KEISP
Y
S
I
VGL
SAT
W
D
V
T
K
---
N
V
S
L
TGG
VDNLFDK
-
-
---R
L
WRA
G
N
AQT
TGDL
AG
ANYIA
G
A
G
A
---
Y
T
Y
NE
PGR
TW
Y
MSVN
TH
F
fig|566546.4.peg.641
Escherichia coli W (47-746/746)
A
P
G
VS
T
I
TA
D
EIR
K
N
-
PVAR
D
V
SE
I
I
R
T
-
M
PGV
N
L
TGN
S
TS
G
QR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
K
P
VSSRNS
VRQG
WR
G
E
R
D
TR
G
----
D
T
SWV
PP
-
EM
IERIEVLRGP
A
A
A
R
YGN
G
A
A
GGVVNIITKKG
S
--------------
GE
W
HG
S
WD
A
YF
N
AP
E
HK
E
E
---
G
----
AT
K
RT
NF
SLT
GPL
-
G
D
EFSF
R
LY
G
NLD
K
TQ
A
D
A
WDINQ
--
GHQSARAGTYA
T
T
L
PAGR
E
GVI
N
K
D
I
N
G
VV
--
R
W
D
F
A
P
L
Q
S
L
EL
E
AGY
SRQ
GNLYA
GDT
Q
NT
N
S
D
A
Y
TR
S
-
-KY
-----------------
G
D
E
T
N
R
L
YR
QNYALTWNGGWDN
G
V
TTSNWVQ
Y
EH
T
R
---------
N
---------
-
S
R
---
IPE
GL
A
G
GTE
GKFNEKA
T
QDFV
DIDL
D
DVMLH
SE
V
NL
PI
DFLVNQ
T
L
T
L
G
T
EW
NQQ
R
MK
D
LSSNTQA
L
TGANTG
G
AI
D
G
VSATDRSPYSKA
E
IF
SL
---
-
--
FAE
NNME
LTD
S
T
I
V
T
P
G
L
R
F
--------
DH
------------
HSIV
GN
----------
N
WSP
ALN
I
SQG
L
G
D
D
F
T
LK
M
G
IA
R
A
YKAP
S
L
Y
Q
TNPNYI
L
YSKGQ
G
CYA
--
SA
G
GCY
L
-----
Q
GN
D
DLK
A
E
T
S
I
N
K
EIG
LEF-KRD
G
W
L
A
G
VT
W
F
R
N
D
YR
NKI
E
A
GYVAVGQ
N
A
VGTDLYQ
W
D
N
V
P
KA
V
VE
G
L
E
G
S
LNV
P
-
VSE
T
VMWTN
N
I
T
Y
M
-------
LK
SE
N
KT
---
T
G
D
----
RLS
I
IPEY
T
L
N
S
T
L
S
W
QAR
E
DLSMQTTF
T
WY
GK
QQ
P
KKY
-
NY
KGQP
AV
-----
G
PE
T
KEISP
Y
S
I
VGL
SAT
W
D
V
T
K
---
N
V
S
L
TGG
VDNLFDK
-
-
---R
L
WRA
G
N
AQT
TGDL
AG
ANYIA
G
A
G
A
---
Y
T
Y
NE
PGR
TW
Y
MSVN
TH
F
fig|358709.5.peg.1967
Escherichia coli 101-1 (47-746/746)
A
P
G
VS
T
I
TA
D
EIR
K
N
-
PVAR
D
V
SE
I
I
R
T
-
M
PGV
N
L
TGN
S
TS
G
QR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
K
P
VSSRNS
VRQG
WR
G
E
R
D
TR
G
----
D
T
SWV
PP
-
EM
IERIEVLRGP
A
A
A
R
YGN
G
A
A
GGVVNIITKKG
S
--------------
GE
W
HG
S
WD
A
YF
N
AP
E
HK
E
E
---
G
----
AT
K
RT
NF
SLT
GPL
-
G
D
EFSF
R
LY
G
NLD
K
TQ
A
D
A
WDINQ
--
GHQSARAGTYA
T
T
L
PAGR
E
GVI
N
K
D
I
N
G
VV
--
R
W
D
F
A
P
L
Q
S
L
EL
E
AGY
SRQ
GNLYA
GDT
Q
NT
N
S
D
S
Y
TR
S
-
-KY
-----------------
G
D
E
T
N
R
L
YR
QNYALTWNGGWDN
G
V
TTSNWVQ
Y
EH
T
R
---------
N
---------
-
S
R
---
IPE
GL
A
G
GTE
GKFNEKA
T
QDFV
DIDL
D
DVMLH
SE
V
NL
PI
DFLVNQ
T
L
T
L
G
T
EW
NQQ
R
MK
D
LSSNTQA
L
TGTNTG
G
AI
D
G
VSTTDRSPYSKA
E
IF
SL
---
-
--
FAE
NNME
LTD
S
T
I
V
T
P
G
L
R
F
--------
DH
------------
HSIV
GN
----------
N
WSP
ALN
I
SQG
L
G
D
D
F
T
LK
M
G
IA
R
A
YKAP
S
L
Y
Q
TNPNYI
L
YSKGQ
G
CYA
--
SA
G
GCY
L
-----
Q
GN
D
DLK
A
E
T
S
I
N
K
EIG
LEF-KRD
G
W
L
A
G
VT
W
F
R
N
D
YR
NKI
E
A
GYVAVGQ
N
A
VGTDLYQ
W
D
N
V
P
KA
V
VE
G
L
E
G
S
LNV
P
-
VSE
T
VMWTN
N
I
T
Y
M
-------
LK
SE
N
KT
---
T
G
D
----
RLS
I
IPEY
T
L
N
S
T
L
S
W
QAR
E
DLSMQTTF
T
WY
GK
QQ
P
KKY
-
NY
KGQP
AV
-----
G
PE
T
KEISP
Y
S
I
VGL
SAT
W
D
V
T
K
---
N
V
S
L
TGG
VDNLFDK
-
-
---R
L
WRA
G
N
AQT
TGDL
AG
ANYIA
G
A
G
A
---
Y
T
Y
NE
PGR
TW
Y
MSVN
TH
F
fig|413997.3.peg.577
Escherichia coli B str. REL606 (47-746/746)
A
P
G
VS
T
I
TA
D
EIR
K
N
-
PVAR
D
V
SE
I
I
R
T
-
M
PGV
N
L
TGN
S
TS
G
QR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
K
P
VSSRNS
VRQG
WR
G
E
R
D
TR
G
----
D
T
SWV
PP
-
EM
IERIEVLRGP
A
A
A
R
YGN
G
A
A
GGVVNIITKKG
S
--------------
GE
W
HG
S
WD
A
YF
N
AP
E
HK
E
E
---
G
----
AT
K
RT
NF
SLT
GPL
-
G
D
EFSF
R
LY
G
NLD
K
TQ
A
D
A
WDINQ
--
GHQSARAGTYA
T
T
L
PAGR
E
GVI
N
K
D
I
N
G
VV
--
R
W
D
F
A
P
L
Q
S
L
EL
E
AGY
SRQ
GNLYA
GDT
Q
NT
N
S
D
S
Y
TR
S
-
-KY
-----------------
G
D
E
T
N
R
L
YR
QNYALTWNGGWDN
G
V
TTSNWVQ
Y
EH
T
R
---------
N
---------
-
S
R
---
IPE
GL
A
G
GTE
GKFNEKA
T
QDFV
DIDL
D
DVMLH
SE
V
NL
PI
DFLVNQ
T
L
T
L
G
T
EW
NQQ
R
MK
D
LSSNTQA
L
TGTNTG
G
AI
D
G
VSTTDRSPYSKA
E
IF
SL
---
-
--
FAE
NNME
LTD
S
T
I
V
T
P
G
L
R
F
--------
DH
------------
HSIV
GN
----------
N
WSP
ALN
I
SQG
L
G
D
D
F
T
LK
M
G
IA
R
A
YKAP
S
L
Y
Q
TNPNYI
L
YSKGQ
G
CYA
--
SA
G
GCY
L
-----
Q
GN
D
DLK
A
E
T
S
I
N
K
EIG
LEF-KRD
G
W
L
A
G
VT
W
F
R
N
D
YR
NKI
E
A
GYVAVGQ
N
A
VGTDLYQ
W
D
N
V
P
KA
V
VE
G
L
E
G
S
LNV
P
-
VSE
T
VMWTN
N
I
T
Y
M
-------
LK
SE
N
KT
---
T
G
D
----
RLS
I
IPEY
T
L
N
S
T
L
S
W
QAR
E
DLSMQTTF
T
WY
GK
QQ
P
KKY
-
NY
KGQP
AV
-----
G
PE
T
KEISP
Y
S
I
VGL
SAT
W
D
V
T
K
---
N
V
S
L
TGG
VDNLFDK
-
-
---R
L
WRA
G
N
AQT
TGDL
AG
ANYIA
G
A
G
A
---
Y
T
Y
NE
PGR
TW
Y
MSVN
TH
F
fig|511693.5.peg.573
Escherichia coli BL21 (47-746/746)
A
P
G
VS
T
I
TA
D
EIR
K
N
-
PVAR
D
V
SE
I
I
R
T
-
M
PGV
N
L
TGN
S
TS
G
QR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
K
P
VSSRNS
VRQG
WR
G
E
R
D
TR
G
----
D
T
SWV
PP
-
EM
IERIEVLRGP
A
A
A
R
YGN
G
A
A
GGVVNIITKKG
S
--------------
GE
W
HG
S
WD
A
YF
N
AP
E
HK
E
E
---
G
----
AT
K
RT
NF
SLT
GPL
-
G
D
EFSF
R
LY
G
NLD
K
TQ
A
D
A
WDINQ
--
GHQSARAGTYA
T
T
L
PAGR
E
GVI
N
K
D
I
N
G
VV
--
R
W
D
F
A
P
L
Q
S
L
EL
E
AGY
SRQ
GNLYA
GDT
Q
NT
N
S
D
S
Y
TR
S
-
-KY
-----------------
G
D
E
T
N
R
L
YR
QNYALTWNGGWDN
G
V
TTSNWVQ
Y
EH
T
R
---------
N
---------
-
S
R
---
IPE
GL
A
G
GTE
GKFNEKA
T
QDFV
DIDL
D
DVMLH
SE
V
NL
PI
DFLVNQ
T
L
T
L
G
T
EW
NQQ
R
MK
D
LSSNTQA
L
TGTNTG
G
AI
D
G
VSTTDRSPYSKA
E
IF
SL
---
-
--
FAE
NNME
LTD
S
T
I
V
T
P
G
L
R
F
--------
DH
------------
HSIV
GN
----------
N
WSP
ALN
I
SQG
L
G
D
D
F
T
LK
M
G
IA
R
A
YKAP
S
L
Y
Q
TNPNYI
L
YSKGQ
G
CYA
--
SA
G
GCY
L
-----
Q
GN
D
DLK
A
E
T
S
I
N
K
EIG
LEF-KRD
G
W
L
A
G
VT
W
F
R
N
D
YR
NKI
E
A
GYVAVGQ
N
A
VGTDLYQ
W
D
N
V
P
KA
V
VE
G
L
E
G
S
LNV
P
-
VSE
T
VMWTN
N
I
T
Y
M
-------
LK
SE
N
KT
---
T
G
D
----
RLS
I
IPEY
T
L
N
S
T
L
S
W
QAR
E
DLSMQTTF
T
WY
GK
QQ
P
KKY
-
NY
KGQP
AV
-----
G
PE
T
KEISP
Y
S
I
VGL
SAT
W
D
V
T
K
---
N
V
S
L
TGG
VDNLFDK
-
-
---R
L
WRA
G
N
AQT
TGDL
AG
ANYIA
G
A
G
A
---
Y
T
Y
NE
PGR
TW
Y
MSVN
TH
F
fig|469008.4.peg.3182
Escherichia coli BL21(DE3) (47-746/746)
A
P
G
VS
T
I
TA
D
EIR
K
N
-
PVAR
D
V
SE
I
I
R
T
-
M
PGV
N
L
TGN
S
TS
G
QR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
K
P
VSSRNS
VRQG
WR
G
E
R
D
TR
G
----
D
T
SWV
PP
-
EM
IERIEVLRGP
A
A
A
R
YGN
G
A
A
GGVVNIITKKG
S
--------------
GE
W
HG
S
WD
A
YF
N
AP
E
HK
E
E
---
G
----
AT
K
RT
NF
SLT
GPL
-
G
D
EFSF
R
LY
G
NLD
K
TQ
A
D
A
WDINQ
--
GHQSARAGTYA
T
T
L
PAGR
E
GVI
N
K
D
I
N
G
VV
--
R
W
D
F
A
P
L
Q
S
L
EL
E
AGY
SRQ
GNLYA
GDT
Q
NT
N
S
D
S
Y
TR
S
-
-KY
-----------------
G
D
E
T
N
R
L
YR
QNYALTWNGGWDN
G
V
TTSNWVQ
Y
EH
T
R
---------
N
---------
-
S
R
---
IPE
GL
A
G
GTE
GKFNEKA
T
QDFV
DIDL
D
DVMLH
SE
V
NL
PI
DFLVNQ
T
L
T
L
G
T
EW
NQQ
R
MK
D
LSSNTQA
L
TGTNTG
G
AI
D
G
VSTTDRSPYSKA
E
IF
SL
---
-
--
FAE
NNME
LTD
S
T
I
V
T
P
G
L
R
F
--------
DH
------------
HSIV
GN
----------
N
WSP
ALN
I
SQG
L
G
D
D
F
T
LK
M
G
IA
R
A
YKAP
S
L
Y
Q
TNPNYI
L
YSKGQ
G
CYA
--
SA
G
GCY
L
-----
Q
GN
D
DLK
A
E
T
S
I
N
K
EIG
LEF-KRD
G
W
L
A
G
VT
W
F
R
N
D
YR
NKI
E
A
GYVAVGQ
N
A
VGTDLYQ
W
D
N
V
P
KA
V
VE
G
L
E
G
S
LNV
P
-
VSE
T
VMWTN
N
I
T
Y
M
-------
LK
SE
N
KT
---
T
G
D
----
RLS
I
IPEY
T
L
N
S
T
L
S
W
QAR
E
DLSMQTTF
T
WY
GK
QQ
P
KKY
-
NY
KGQP
AV
-----
G
PE
T
KEISP
Y
S
I
VGL
SAT
W
D
V
T
K
---
N
V
S
L
TGG
VDNLFDK
-
-
---R
L
WRA
G
N
AQT
TGDL
AG
ANYIA
G
A
G
A
---
Y
T
Y
NE
PGR
TW
Y
MSVN
TH
F
fig|316401.4.peg.702
Escherichia coli ETEC H10407 (47-746/746)
A
P
G
VS
T
I
TA
D
EIR
K
N
-
PVAR
D
V
SE
I
I
R
T
-
M
PGV
N
L
TGN
S
TS
G
QR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
K
P
VSSRNS
VRQG
WR
G
E
R
D
TR
G
----
D
T
SWV
PP
-
EM
IERIEVLRGP
A
A
A
R
YGN
G
A
A
GGVVNIITKKG
S
--------------
GE
W
HG
S
WD
A
YF
N
AP
E
HK
E
E
---
G
----
AT
K
RT
NF
SLT
GPL
-
G
D
EFSF
R
LY
G
NLD
K
TQ
A
D
A
WDINQ
--
GHQSARAGTYA
T
T
L
PAGR
E
GVI
N
K
D
I
N
G
VV
--
R
W
D
F
A
P
L
Q
S
L
EL
E
AGY
SRQ
GNLYA
GDT
Q
NT
N
S
D
S
Y
TR
S
-
-KY
-----------------
G
D
E
T
N
R
L
YR
QNYALTWNGGWDN
G
V
TTSNWVQ
Y
EH
T
R
---------
N
---------
-
S
R
---
IPE
GL
A
G
GTE
GKFNEKA
T
QDFV
DIDL
D
DVMLH
SE
V
NL
PI
DFLVNQ
T
L
T
L
G
T
EW
NQQ
R
MK
D
LSSNTQA
L
TGTNTG
G
AI
D
G
VSTTDRSPYSKA
E
IF
SL
---
-
--
FAE
NNME
LTD
S
T
I
V
T
P
G
L
R
F
--------
DH
------------
HSIV
GN
----------
N
WSP
ALN
I
SQG
L
G
D
D
F
T
LK
M
G
IA
R
A
YKAP
S
L
Y
Q
TNPNYI
L
YSKGQ
G
CYA
--
SA
G
GCY
L
-----
Q
GN
D
DLK
A
E
T
S
I
N
K
EIG
LEF-KRD
G
W
L
A
G
VT
W
F
R
N
D
YR
NKI
E
A
GYVAVGQ
N
A
VGTDLYQ
W
D
N
V
P
KA
V
VE
G
L
E
G
S
LNV
P
-
VSE
T
VMWTN
N
I
T
Y
M
-------
LK
SE
N
KT
---
T
G
D
----
RLS
I
IPEY
T
L
N
S
T
L
S
W
QAR
E
DLSMQTTF
T
WY
GK
QQ
P
KKY
-
NY
KGQP
AV
-----
G
PE
T
KEISP
Y
S
I
VGL
SAT
W
D
V
T
K
---
N
V
S
L
TGG
VDNLFDK
-
-
---R
L
WRA
G
N
AQT
TGDL
AG
ANYIA
G
A
G
A
---
Y
T
Y
NE
PGR
TW
Y
MSVN
TH
F
fig|656414.3.peg.758
Escherichia coli H736 (47-746/746)
A
P
G
VS
T
I
TA
D
EIR
K
N
-
PVAR
D
V
SE
I
I
R
T
-
M
PGV
N
L
TGN
S
TS
G
QR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
K
P
VSSRNS
VRQG
WR
G
E
R
D
TR
G
----
D
T
SWV
PP
-
EM
IERIEVLRGP
A
A
A
R
YGN
G
A
A
GGVVNIITKKG
S
--------------
GE
W
HG
S
WD
A
YF
N
AP
E
HK
E
E
---
G
----
AT
K
RT
NF
SLT
GPL
-
G
D
EFSF
R
LY
G
NLD
K
TQ
A
D
A
WDINQ
--
GHQSARAGTYA
T
T
L
PAGR
E
GVI
N
K
D
I
N
G
VV
--
R
W
D
F
A
P
L
Q
S
L
EL
E
AGY
SRQ
GNLYA
GDT
Q
NT
N
S
D
S
Y
TR
S
-
-KY
-----------------
G
D
E
T
N
R
L
YR
QNYALTWNGGWDN
G
V
TTSNWVQ
Y
EH
T
R
---------
N
---------
-
S
R
---
IPE
GL
A
G
GTE
GKFNEKA
T
QDFV
DIDL
D
DVMLH
SE
V
NL
PI
DFLVNQ
T
L
T
L
G
T
EW
NQQ
R
MK
D
LSSNTQA
L
TGTNTG
G
AI
D
G
VSTTDRSPYSKA
E
IF
SL
---
-
--
FAE
NNME
LTD
S
T
I
V
T
P
G
L
R
F
--------
DH
------------
HSIV
GN
----------
N
WSP
ALN
I
SQG
L
G
D
D
F
T
LK
M
G
IA
R
A
YKAP
S
L
Y
Q
TNPNYI
L
YSKGQ
G
CYA
--
SA
G
GCY
L
-----
Q
GN
D
DLK
A
E
T
S
I
N
K
EIG
LEF-KRD
G
W
L
A
G
VT
W
F
R
N
D
YR
NKI
E
A
GYVAVGQ
N
A
VGTDLYQ
W
D
N
V
P
KA
V
VE
G
L
E
G
S
LNV
P
-
VSE
T
VMWTN
N
I
T
Y
M
-------
LK
SE
N
KT
---
T
G
D
----
RLS
I
IPEY
T
L
N
S
T
L
S
W
QAR
E
DLSMQTTF
T
WY
GK
QQ
P
KKY
-
NY
KGQP
AV
-----
G
PE
T
KEISP
Y
S
I
VGL
SAT
W
D
V
T
K
---
N
V
S
L
TGG
VDNLFDK
-
-
---R
L
WRA
G
N
AQT
TGDL
AG
ANYIA
G
A
G
A
---
Y
T
Y
NE
PGR
TW
Y
MSVN
TH
F
fig|749540.3.peg.4747
Escherichia coli MS 146-1 (47-746/746)
A
P
G
VS
T
I
TA
D
EIR
K
N
-
PVAR
D
V
SE
I
I
R
T
-
M
PGV
N
L
TGN
S
TS
G
QR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
K
P
VSSRNS
VRQG
WR
G
E
R
D
TR
G
----
D
T
SWV
PP
-
EM
IERIEVLRGP
A
A
A
R
YGN
G
A
A
GGVVNIITKKG
S
--------------
GE
W
HG
S
WD
A
YF
N
AP
E
HK
E
E
---
G
----
AT
K
RT
NF
SLT
GPL
-
G
D
EFSF
R
LY
G
NLD
K
TQ
A
D
A
WDINQ
--
GHQSARAGTYA
T
T
L
PAGR
E
GVI
N
K
D
I
N
G
VV
--
R
W
D
F
A
P
L
Q
S
L
EL
E
AGY
SRQ
GNLYA
GDT
Q
NT
N
S
D
S
Y
TR
S
-
-KY
-----------------
G
D
E
T
N
R
L
YR
QNYALTWNGGWDN
G
V
TTSNWVQ
Y
EH
T
R
---------
N
---------
-
S
R
---
IPE
GL
A
G
GTE
GKFNEKA
T
QDFV
DIDL
D
DVMLH
SE
V
NL
PI
DFLVNQ
T
L
T
L
G
T
EW
NQQ
R
MK
D
LSSNTQA
L
TGTNTG
G
AI
D
G
VSTTDRSPYSKA
E
IF
SL
---
-
--
FAE
NNME
LTD
S
T
I
V
T
P
G
L
R
F
--------
DH
------------
HSIV
GN
----------
N
WSP
ALN
I
SQG
L
G
D
D
F
T
LK
M
G
IA
R
A
YKAP
S
L
Y
Q
TNPNYI
L
YSKGQ
G
CYA
--
SA
G
GCY
L
-----
Q
GN
D
DLK
A
E
T
S
I
N
K
EIG
LEF-KRD
G
W
L
A
G
VT
W
F
R
N
D
YR
NKI
E
A
GYVAVGQ
N
A
VGTDLYQ
W
D
N
V
P
KA
V
VE
G
L
E
G
S
LNV
P
-
VSE
T
VMWTN
N
I
T
Y
M
-------
LK
SE
N
KT
---
T
G
D
----
RLS
I
IPEY
T
L
N
S
T
L
S
W
QAR
E
DLSMQTTF
T
WY
GK
QQ
P
KKY
-
NY
KGQP
AV
-----
G
PE
T
KEISP
Y
S
I
VGL
SAT
W
D
V
T
K
---
N
V
S
L
TGG
VDNLFDK
-
-
---R
L
WRA
G
N
AQT
TGDL
AG
ANYIA
G
A
G
A
---
Y
T
Y
NE
PGR
TW
Y
MSVN
TH
F
fig|749548.3.peg.4449
Escherichia coli MS 196-1 (47-746/746)
A
P
G
VS
T
I
TA
D
EIR
K
N
-
PVAR
D
V
SE
I
I
R
T
-
M
PGV
N
L
TGN
S
TS
G
QR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
K
P
VSSRNS
VRQG
WR
G
E
R
D
TR
G
----
D
T
SWV
PP
-
EM
IERIEVLRGP
A
A
A
R
YGN
G
A
A
GGVVNIITKKG
S
--------------
GE
W
HG
S
WD
A
YF
N
AP
E
HK
E
E
---
G
----
AT
K
RT
NF
SLT
GPL
-
G
D
EFSF
R
LY
G
NLD
K
TQ
A
D
A
WDINQ
--
GHQSARAGTYA
T
T
L
PAGR
E
GVI
N
K
D
I
N
G
VV
--
R
W
D
F
A
P
L
Q
S
L
EL
E
AGY
SRQ
GNLYA
GDT
Q
NT
N
S
D
S
Y
TR
S
-
-KY
-----------------
G
D
E
T
N
R
L
YR
QNYALTWNGGWDN
G
V
TTSNWVQ
Y
EH
T
R
---------
N
---------
-
S
R
---
IPE
GL
A
G
GTE
GKFNEKA
T
QDFV
DIDL
D
DVMLH
SE
V
NL
PI
DFLVNQ
T
L
T
L
G
T
EW
NQQ
R
MK
D
LSSNTQA
L
TGTNTG
G
AI
D
G
VSTTDRSPYSKA
E
IF
SL
---
-
--
FAE
NNME
LTD
S
T
I
V
T
P
G
L
R
F
--------
DH
------------
HSIV
GN
----------
N
WSP
ALN
I
SQG
L
G
D
D
F
T
LK
M
G
IA
R
A
YKAP
S
L
Y
Q
TNPNYI
L
YSKGQ
G
CYA
--
SA
G
GCY
L
-----
Q
GN
D
DLK
A
E
T
S
I
N
K
EIG
LEF-KRD
G
W
L
A
G
VT
W
F
R
N
D
YR
NKI
E
A
GYVAVGQ
N
A
VGTDLYQ
W
D
N
V
P
KA
V
VE
G
L
E
G
S
LNV
P
-
VSE
T
VMWTN
N
I
T
Y
M
-------
LK
SE
N
KT
---
T
G
D
----
RLS
I
IPEY
T
L
N
S
T
L
S
W
QAR
E
DLSMQTTF
T
WY
GK
QQ
P
KKY
-
NY
KGQP
AV
-----
G
PE
T
KEISP
Y
S
I
VGL
SAT
W
D
V
T
K
---
N
V
S
L
TGG
VDNLFDK
-
-
---R
L
WRA
G
N
AQT
TGDL
AG
ANYIA
G
A
G
A
---
Y
T
Y
NE
PGR
TW
Y
MSVN
TH
F
fig|679207.4.peg.2879
Escherichia coli MS 107-1 (47-746/746)
A
P
G
VS
T
I
TA
D
EIR
K
N
-
PVAR
D
V
SE
I
I
R
T
-
M
PGV
N
L
TGN
S
TS
G
QR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
K
P
VSSRNS
VRQG
WR
G
E
R
D
TR
G
----
D
T
SWV
PP
-
EM
IERIEVLRGP
A
A
A
R
YGN
G
A
A
GGVVNIITKKG
S
--------------
GE
W
HG
S
WD
A
YF
N
AP
E
HK
E
E
---
G
----
AT
K
RT
NF
SLT
GPL
-
G
D
EFSF
H
LY
G
NLD
K
TQ
A
D
A
WDINQ
--
GHQSARAGTYA
T
T
L
PAGR
E
GVI
N
K
D
I
N
G
VV
--
R
W
D
F
A
P
L
Q
S
L
EL
E
AGY
SRQ
GNLYA
GDT
Q
NT
N
S
D
A
Y
TR
S
-
-KY
-----------------
G
D
E
T
N
R
L
YR
QNYALTWNGGWDN
G
V
TTSNWVQ
Y
EH
T
R
---------
N
---------
-
S
R
---
IPE
GL
A
G
GTE
GKFNEKA
T
QDFV
DIDL
D
DVMLH
SE
V
NL
PI
DFLVNQ
T
L
T
L
G
T
EW
NQQ
R
MK
D
LSSNTQA
L
TGANTG
G
AI
D
G
VSATDRSPYSKA
E
IF
SL
---
-
--
FAE
NNME
LTD
S
T
I
V
T
P
G
L
R
F
--------
DH
------------
HSIV
GN
----------
N
WSP
ALN
I
SQG
L
G
D
D
F
T
LK
M
G
IA
R
A
YKAP
S
L
Y
Q
TNPNYI
L
YSKGQ
G
CYA
--
SA
G
GCY
L
-----
Q
GN
D
DLK
A
E
T
S
I
N
K
EIG
LEF-KRD
G
W
L
A
G
VT
W
F
R
N
D
YR
NKI
E
A
GYVAVGQ
N
A
VGTDLYQ
W
D
N
V
P
KA
V
VE
G
L
E
G
S
LNV
P
-
VSE
T
VMWTN
N
I
T
Y
M
-------
LK
SE
N
KT
---
T
G
D
----
RLS
I
IPEY
T
L
N
S
T
L
S
W
QAR
E
DLSMQTTF
T
WY
GK
QQ
P
KKY
-
NY
KGQP
AV
-----
G
PE
T
KEISP
Y
S
I
VGL
SAT
W
D
V
T
K
---
N
V
S
L
TGG
VDNLFDK
-
-
---R
L
WRA
G
N
AQT
TGDL
AG
ANYIA
G
A
G
A
---
Y
T
Y
NE
PGR
TW
Y
MSVN
TH
F
fig|670888.3.peg.1147
Escherichia coli 1827-70 (47-746/746)
A
P
G
VS
T
I
TA
D
EIR
K
N
-
PVAR
D
V
SE
I
I
R
T
-
M
PGV
N
L
TGN
S
TS
G
QR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
K
P
VSSRNS
VRQG
WR
G
E
R
D
TR
G
----
D
T
SWV
PP
-
EM
IERIEVLRGP
A
A
A
R
YGN
G
A
A
GGVVNIITKKG
S
--------------
GE
W
HG
S
WD
A
YF
N
AP
E
HK
E
E
---
G
----
AT
K
RT
NF
SLT
GPL
-
G
D
EFSF
R
LY
G
NLD
K
TQ
A
D
A
WDINQ
--
GHQSARAGTYA
T
T
L
PAGR
E
GVI
N
K
D
I
N
G
VV
--
R
W
D
F
A
P
L
Q
S
L
EL
E
AGY
SRQ
GNLYA
GDT
Q
NT
N
S
D
S
Y
TR
S
-
-KY
-----------------
G
D
E
T
N
R
L
YR
QNYALTWNGGWDN
G
V
TTSNWVQ
Y
EH
T
R
---------
N
---------
-
S
R
---
IPE
GL
A
G
GTE
GKFNEKA
T
QDFV
DIDL
D
DVMLH
SE
V
NL
PI
DFLVNQ
T
L
T
L
G
T
EW
NQQ
R
MK
D
LSSNTQA
L
TGTNTG
G
AI
D
G
VSATDRSPYSKA
E
IF
SL
---
-
--
FAE
NNME
LTD
S
T
I
V
T
P
G
L
R
F
--------
DH
------------
HSIV
GN
----------
N
WSP
ALN
I
SQG
L
G
D
D
F
T
LK
M
G
IA
R
A
YKAP
S
L
Y
Q
TNPNYI
L
YSKGQ
G
CYA
--
SA
G
GCY
L
-----
Q
GN
D
DLK
A
E
T
S
I
N
K
EIG
LEF-KRD
G
W
L
A
G
VT
W
F
R
N
D
YR
NKI
E
A
GYVAVGQ
N
A
VGTDLYQ
W
D
N
V
P
KA
V
VE
G
L
E
G
S
LNV
P
-
VSE
T
VMWTN
N
I
T
Y
M
-------
LK
SE
N
KT
---
T
G
D
----
RLS
I
IPEY
T
L
N
S
T
L
S
W
QAR
E
DLSMQTTF
T
WY
GK
QQ
P
KKY
-
NY
KGQP
AV
-----
G
PE
T
KEISP
Y
S
I
VGL
SAT
W
D
V
T
K
---
N
V
S
L
TGG
VDNLFDK
-
-
---R
L
WRA
G
N
AQT
TGDL
AG
ANYIA
G
A
G
A
---
Y
T
Y
NE
PGR
TW
Y
MSVN
TH
F
fig|481805.3.peg.3284
Escherichia coli ATCC 8739 (47-746/746)
A
P
G
VS
T
I
TA
D
EIR
K
N
-
PVAR
D
V
SE
I
I
R
T
-
M
PGV
N
L
TGN
S
TS
G
QR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
K
P
VSSRNS
VRQG
WR
G
E
R
D
TR
G
----
D
T
SWV
PP
-
EM
IERIEVLRGP
A
A
A
R
YGN
G
A
A
GGVVNIITKKG
S
--------------
GE
W
HG
S
WD
A
YF
N
AP
E
HK
E
E
---
G
----
AT
K
RT
NF
SLT
GPL
-
G
D
EFSF
R
LY
G
NLD
K
TQ
A
D
A
WDINQ
--
GHQSARAGTYA
T
T
L
PAGR
E
GVI
N
K
D
I
N
G
VV
--
R
W
D
F
A
P
L
Q
S
L
EL
E
AGY
SRQ
GNLYA
GDT
Q
NT
N
S
D
S
Y
TR
S
-
-KY
-----------------
G
D
E
T
N
R
L
YR
QNYALTWNGGWDN
G
V
TTSNWVQ
Y
EH
T
R
---------
N
---------
-
S
R
---
IPE
GL
A
G
GTE
GKFNEKA
T
QDFV
DIDL
D
DVMLH
SE
V
NL
PI
DFLVNQ
T
L
T
L
G
T
EW
NQQ
R
MK
D
LSSNTQA
L
TGTNTG
G
AI
D
G
VSATDRSPYSKA
E
IF
SL
---
-
--
FAE
NNME
LTD
S
T
I
V
T
P
G
L
R
F
--------
DH
------------
HSIV
GN
----------
N
WSP
ALN
I
SQG
L
G
D
D
F
T
LK
M
G
IA
R
A
YKAP
S
L
Y
Q
TNPNYI
L
YSKGQ
G
CYA
--
SA
G
GCY
L
-----
Q
GN
D
DLK
A
E
T
S
I
N
K
EIG
LEF-KRD
G
W
L
A
G
VT
W
F
R
N
D
YR
NKI
E
A
GYVAVGQ
N
A
VGTDLYQ
W
D
N
V
P
KA
V
VE
G
L
E
G
S
LNV
P
-
VSE
T
VMWTN
N
I
T
Y
M
-------
LK
SE
N
KT
---
T
G
D
----
RLS
I
IPEY
T
L
N
S
T
L
S
W
QAR
E
DLSMQTTF
T
WY
GK
QQ
P
KKY
-
NY
KGQP
AV
-----
G
PE
T
KEISP
Y
S
I
VGL
SAT
W
D
V
T
K
---
N
V
S
L
TGG
VDNLFDK
-
-
---R
L
WRA
G
N
AQT
TGDL
AG
ANYIA
G
A
G
A
---
Y
T
Y
NE
PGR
TW
Y
MSVN
TH
F
fig|481805.6.peg.3270
Escherichia coli ATCC 8739 (47-746/746)
A
P
G
VS
T
I
TA
D
EIR
K
N
-
PVAR
D
V
SE
I
I
R
T
-
M
PGV
N
L
TGN
S
TS
G
QR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
K
P
VSSRNS
VRQG
WR
G
E
R
D
TR
G
----
D
T
SWV
PP
-
EM
IERIEVLRGP
A
A
A
R
YGN
G
A
A
GGVVNIITKKG
S
--------------
GE
W
HG
S
WD
A
YF
N
AP
E
HK
E
E
---
G
----
AT
K
RT
NF
SLT
GPL
-
G
D
EFSF
R
LY
G
NLD
K
TQ
A
D
A
WDINQ
--
GHQSARAGTYA
T
T
L
PAGR
E
GVI
N
K
D
I
N
G
VV
--
R
W
D
F
A
P
L
Q
S
L
EL
E
AGY
SRQ
GNLYA
GDT
Q
NT
N
S
D
S
Y
TR
S
-
-KY
-----------------
G
D
E
T
N
R
L
YR
QNYALTWNGGWDN
G
V
TTSNWVQ
Y
EH
T
R
---------
N
---------
-
S
R
---
IPE
GL
A
G
GTE
GKFNEKA
T
QDFV
DIDL
D
DVMLH
SE
V
NL
PI
DFLVNQ
T
L
T
L
G
T
EW
NQQ
R
MK
D
LSSNTQA
L
TGTNTG
G
AI
D
G
VSATDRSPYSKA
E
IF
SL
---
-
--
FAE
NNME
LTD
S
T
I
V
T
P
G
L
R
F
--------
DH
------------
HSIV
GN
----------
N
WSP
ALN
I
SQG
L
G
D
D
F
T
LK
M
G
IA
R
A
YKAP
S
L
Y
Q
TNPNYI
L
YSKGQ
G
CYA
--
SA
G
GCY
L
-----
Q
GN
D
DLK
A
E
T
S
I
N
K
EIG
LEF-KRD
G
W
L
A
G
VT
W
F
R
N
D
YR
NKI
E
A
GYVAVGQ
N
A
VGTDLYQ
W
D
N
V
P
KA
V
VE
G
L
E
G
S
LNV
P
-
VSE
T
VMWTN
N
I
T
Y
M
-------
LK
SE
N
KT
---
T
G
D
----
RLS
I
IPEY
T
L
N
S
T
L
S
W
QAR
E
DLSMQTTF
T
WY
GK
QQ
P
KKY
-
NY
KGQP
AV
-----
G
PE
T
KEISP
Y
S
I
VGL
SAT
W
D
V
T
K
---
N
V
S
L
TGG
VDNLFDK
-
-
---R
L
WRA
G
N
AQT
TGDL
AG
ANYIA
G
A
G
A
---
Y
T
Y
NE
PGR
TW
Y
MSVN
TH
F
fig|331112.3.peg.589
Escherichia coli HS (47-746/746)
A
P
G
VS
T
I
TA
D
EIR
K
N
-
PVAR
D
V
SE
I
I
R
T
-
M
PGV
N
L
TGN
S
TS
G
QR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
K
P
VSSRNS
VRQG
WR
G
E
R
D
TR
G
----
D
T
SWV
PP
-
EM
IERIEVLRGP
A
A
A
R
YGN
G
A
A
GGVVNIITKKG
S
--------------
GE
W
HG
S
WD
A
YF
N
AP
E
HK
E
E
---
G
----
AT
K
RT
NF
SLT
GPL
-
G
D
EFSF
R
LY
G
NLD
K
TQ
A
D
A
WDINQ
--
GHQSARAGTYA
T
T
L
PAGR
E
GVI
N
K
D
I
N
G
VV
--
R
W
D
F
A
P
L
Q
S
L
EL
E
AGY
SRQ
GNLYA
GDT
Q
NT
N
S
D
S
Y
TR
S
-
-KY
-----------------
G
D
E
T
N
R
L
YR
QNYALTWNGGWDN
G
V
TTSNWVQ
Y
EH
T
R
---------
N
---------
-
S
R
---
IPE
GL
A
G
GTE
GKFNEKA
T
QDFV
DIDL
D
DVMLH
SE
V
NL
PI
DFLVNQ
T
L
T
L
G
T
EW
NQQ
R
MK
D
LSSNTQV
L
TGTNTG
G
AI
D
G
VSATDRSPYSKA
E
IF
SL
---
-
--
FAE
NNME
LTD
S
T
I
V
T
P
G
L
R
F
--------
DH
------------
HSIV
GN
----------
N
WSP
ALN
I
SQG
L
G
D
D
F
T
LK
M
G
IA
R
A
YKAP
S
L
Y
Q
TNPNYI
L
YSKGQ
G
CYA
--
SA
G
GCY
L
-----
Q
GN
D
DLK
A
E
T
S
I
N
K
EIG
LEF-KRD
G
W
L
A
G
VT
W
F
R
N
D
YR
NKI
E
A
GYVAVGQ
N
A
VGTDLYQ
W
D
N
V
P
KA
V
VE
G
L
E
G
S
LNV
P
-
VSE
T
VMWTN
N
I
T
Y
M
-------
LK
SE
N
KT
---
T
G
D
----
RLS
I
IPEY
T
L
N
S
T
L
S
W
QAR
E
DLSMQTTF
T
WY
GK
QQ
P
KKY
-
NY
KGQP
AV
-----
G
PE
T
KEISP
Y
S
I
VGL
SAT
W
D
V
T
K
---
N
V
S
L
TGG
VDNLFDK
-
-
---R
L
WRA
G
N
AQT
TGDL
AG
ANYIA
G
A
G
A
---
Y
T
Y
NE
PGR
TW
Y
MSVN
TH
F
fig|331112.6.peg.616
Escherichia coli HS (47-746/746)
A
P
G
VS
T
I
TA
D
EIR
K
N
-
PVAR
D
V
SE
I
I
R
T
-
M
PGV
N
L
TGN
S
TS
G
QR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
K
P
VSSRNS
VRQG
WR
G
E
R
D
TR
G
----
D
T
SWV
PP
-
EM
IERIEVLRGP
A
A
A
R
YGN
G
A
A
GGVVNIITKKG
S
--------------
GE
W
HG
S
WD
A
YF
N
AP
E
HK
E
E
---
G
----
AT
K
RT
NF
SLT
GPL
-
G
D
EFSF
R
LY
G
NLD
K
TQ
A
D
A
WDINQ
--
GHQSARAGTYA
T
T
L
PAGR
E
GVI
N
K
D
I
N
G
VV
--
R
W
D
F
A
P
L
Q
S
L
EL
E
AGY
SRQ
GNLYA
GDT
Q
NT
N
S
D
S
Y
TR
S
-
-KY
-----------------
G
D
E
T
N
R
L
YR
QNYALTWNGGWDN
G
V
TTSNWVQ
Y
EH
T
R
---------
N
---------
-
S
R
---
IPE
GL
A
G
GTE
GKFNEKA
T
QDFV
DIDL
D
DVMLH
SE
V
NL
PI
DFLVNQ
T
L
T
L
G
T
EW
NQQ
R
MK
D
LSSNTQV
L
TGTNTG
G
AI
D
G
VSATDRSPYSKA
E
IF
SL
---
-
--
FAE
NNME
LTD
S
T
I
V
T
P
G
L
R
F
--------
DH
------------
HSIV
GN
----------
N
WSP
ALN
I
SQG
L
G
D
D
F
T
LK
M
G
IA
R
A
YKAP
S
L
Y
Q
TNPNYI
L
YSKGQ
G
CYA
--
SA
G
GCY
L
-----
Q
GN
D
DLK
A
E
T
S
I
N
K
EIG
LEF-KRD
G
W
L
A
G
VT
W
F
R
N
D
YR
NKI
E
A
GYVAVGQ
N
A
VGTDLYQ
W
D
N
V
P
KA
V
VE
G
L
E
G
S
LNV
P
-
VSE
T
VMWTN
N
I
T
Y
M
-------
LK
SE
N
KT
---
T
G
D
----
RLS
I
IPEY
T
L
N
S
T
L
S
W
QAR
E
DLSMQTTF
T
WY
GK
QQ
P
KKY
-
NY
KGQP
AV
-----
G
PE
T
KEISP
Y
S
I
VGL
SAT
W
D
V
T
K
---
N
V
S
L
TGG
VDNLFDK
-
-
---R
L
WRA
G
N
AQT
TGDL
AG
ANYIA
G
A
G
A
---
Y
T
Y
NE
PGR
TW
Y
MSVN
TH
F
fig|749537.3.peg.3970
Escherichia coli MS 115-1 (47-746/746)
A
P
G
VS
T
I
TA
D
EIR
K
N
-
PVAR
D
V
SE
I
I
R
T
-
M
PGV
N
L
TGN
S
TS
G
QR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
K
P
VSSRNS
VRQG
WR
G
E
R
D
TR
G
----
D
T
SWV
PP
-
EM
IERIEVLRGP
A
A
A
R
YGN
G
A
A
GGVVNIITKKG
S
--------------
GE
W
HG
S
WD
A
YF
N
AP
E
HK
E
E
---
G
----
AT
K
RT
NF
SLT
GPL
-
G
D
EFSF
R
LY
G
NLD
K
TQ
A
D
A
WDINQ
--
GHQSARAGTYA
T
T
L
PAGR
E
GVI
N
K
D
I
N
G
VV
--
R
W
D
F
A
P
L
Q
S
L
EL
E
AGY
SRQ
GNLYA
GDT
Q
NT
N
S
D
S
Y
TR
S
-
-KY
-----------------
G
D
E
T
N
R
L
YR
QNYALTWNGGWDN
G
V
TTSNWVQ
Y
EH
T
R
---------
N
---------
-
S
R
---
IPE
GL
A
G
GTE
GKFNEKA
T
QDFV
DIDL
D
DVMLH
SE
V
NL
PI
DFLVNQ
T
L
T
L
G
T
EW
NQQ
R
MK
D
LSSNTQA
L
TGTNTG
G
AI
D
G
VSATDRSPYSKA
E
IF
SL
---
-
--
FAE
NNME
LTD
S
T
I
V
T
P
G
L
R
F
--------
DH
------------
HSIV
GN
----------
N
WSP
ALN
I
SQG
L
G
D
D
F
T
LK
M
G
IA
R
A
YKAP
S
L
Y
Q
TNPNYI
L
YSKGQ
G
CYA
--
SA
G
GCY
L
-----
Q
GN
D
DLK
A
E
T
S
I
N
K
EIG
LEF-KRD
G
W
L
A
G
VT
W
F
R
N
D
YR
NKI
E
A
GYVAVGQ
N
A
VGTDLYQ
W
D
N
V
P
KA
V
VE
G
L
E
G
S
LNV
P
-
VSE
T
VMWTN
N
I
T
Y
M
-------
LK
SE
N
KT
---
T
G
D
----
RLS
I
IPEY
T
L
N
S
T
L
S
W
QAR
E
DLSMQTTF
T
WY
GK
QQ
P
KKY
-
NY
KGQP
AV
-----
G
PE
T
KEISP
Y
S
I
VGL
SAT
W
D
V
T
K
---
N
V
S
L
TGG
VDNLFDK
-
-
---R
L
WRA
G
N
AQT
TGDL
AG
ANYIA
G
A
G
A
---
Y
T
Y
NE
PGR
TW
Y
MSVN
TH
F
fig|679204.3.peg.2684
Escherichia coli MS 145-7 (47-746/746)
A
P
G
VS
T
I
TA
D
EIR
K
N
-
PVAR
D
V
SE
I
I
R
T
-
M
PGV
N
L
TGN
S
TS
G
QR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
K
P
VSSRNS
VRQG
WR
G
E
R
D
TR
G
----
D
T
SWV
PP
-
EM
IERIEVLRGP
A
A
A
R
YGN
G
A
A
GGVVNIIT
Q
KG
S
--------------
GE
W
HG
S
WD
A
YF
N
AP
E
HK
E
E
---
G
----
AT
K
RT
NF
SLT
GPL
-
G
D
EFSF
R
LY
G
NLD
K
TQ
A
D
A
WDINQ
--
GHQSARAGTYA
T
T
L
PAGR
E
GVI
N
K
D
I
N
G
VV
--
R
W
D
F
A
P
L
Q
S
L
EL
E
AGY
SRQ
GNLYA
GDT
Q
NT
N
S
D
A
Y
TR
S
-
-KY
-----------------
G
D
E
T
N
R
L
YR
QNYALTWNGGWDN
G
V
TTSNWVQ
Y
EH
T
R
---------
N
---------
-
S
R
---
IPE
GL
A
G
GTE
GKFNEKA
T
QDFV
DIDL
D
DVMLH
SE
V
NL
PI
DFLVNQ
T
L
T
L
G
T
EW
NQQ
R
MK
D
LSSNTQA
L
TGANTG
G
AI
D
G
VSATDRSPYSKA
E
IF
SL
---
-
--
FAE
NNME
LTD
S
T
I
V
T
P
G
L
R
F
--------
DH
------------
HSIV
GN
----------
N
WSP
ALN
I
SQG
L
G
D
D
F
T
LK
M
G
IA
R
A
YKAP
S
L
Y
Q
TNPNYI
L
YSKGQ
G
CYA
--
SA
G
GCY
L
-----
Q
GN
D
DLK
A
E
T
S
I
N
K
EIG
LEF-KRD
G
W
L
A
G
VT
W
F
R
N
D
YR
NKI
E
A
GYVAVGQ
N
A
VGTDLYQ
W
D
N
V
P
KA
V
VE
G
L
E
G
S
LNV
P
-
VSE
T
VMWTN
N
I
T
Y
M
-------
LK
SE
N
KT
---
T
G
D
----
RLS
I
IPEY
T
L
N
S
T
L
S
W
QAR
E
DLSMQTTF
T
WY
GK
QQ
P
KKY
-
NY
KGQP
AV
-----
G
PE
T
KEISP
Y
S
I
VGL
SAT
W
D
V
T
K
---
N
V
S
L
TGG
VDNLFDK
-
-
---R
L
WRA
G
N
AQT
TGDL
AG
ANYIA
G
A
G
A
---
Y
T
Y
NE
PGR
TW
Y
MSVN
TH
F
fig|585057.4.peg.598
Escherichia coli IAI39 (47-746/746)
A
P
G
VS
T
I
TA
D
EIR
K
N
-
PVAR
D
V
SE
I
I
R
T
-
M
PGV
N
L
TGN
S
TS
G
QR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
K
P
VSSRNS
VRQG
WR
G
E
R
D
TR
G
----
D
T
SWV
PP
-
EM
IERIEVLRGP
A
A
A
R
YGN
G
A
A
GGVVNIITKKG
S
--------------
GE
W
HG
S
WD
A
YF
N
AP
E
HK
E
E
---
G
----
AT
K
RT
NF
SLT
GPL
-
G
D
EFSF
R
LY
G
NLD
K
TQ
A
D
A
WDINQ
--
GHQSARAGTYA
T
T
L
PAGR
E
GVI
N
K
D
I
N
G
VV
--
R
W
D
F
A
P
L
Q
S
L
EL
E
AGY
SRQ
GNLYA
GDT
Q
NT
N
S
D
S
Y
TR
S
-
-KY
-----------------
G
D
E
T
N
R
L
YR
QNYSLTWNGGWDN
G
V
TTSNWVQ
Y
EH
T
R
---------
N
---------
-
S
R
---
IPE
GL
A
G
GTE
GKFNEKA
T
QDFV
DIDL
D
DVMLH
SE
V
NL
PI
DFLVNQ
T
L
T
L
G
T
EW
NQQ
R
MK
D
LSSNTQA
L
TGTNTG
G
AI
D
G
VSATDRSPYSKA
E
IF
SL
---
-
--
FAE
NNME
V
TD
S
T
I
V
T
P
G
L
R
F
--------
DH
------------
HSIV
GN
----------
N
WSP
ALN
I
SQG
L
G
D
D
F
T
LK
M
G
IA
R
A
YKAP
S
L
Y
Q
TNPNYI
L
YSKGQ
G
CYA
--
SA
G
GCY
L
-----
Q
GN
D
DLK
A
E
T
S
I
N
K
EIG
LEF-KRD
G
W
L
A
G
VT
W
F
R
N
D
YR
NKI
E
A
GYVAVGQ
N
A
VGTDLYQ
W
D
N
V
P
KA
V
VE
G
L
E
G
S
LNV
P
-
VSE
T
VMWTN
N
I
T
Y
M
-------
LK
SE
N
KT
---
T
G
D
----
RLS
I
IPEY
T
L
N
S
T
L
S
W
QAR
E
DLSMQTTF
T
WY
GK
QQ
P
KKY
-
NY
KGQP
AV
-----
G
PE
T
KEISP
Y
S
I
VGL
SAT
W
D
V
T
K
---
N
V
S
L
TGG
VDNLFDK
-
-
---R
L
WRA
G
N
AQT
TGDL
AG
ANYIA
G
A
G
A
---
Y
T
Y
NE
PGR
TW
Y
MSVN
TH
F
fig|585057.6.peg.596
Escherichia coli IAI39 (47-746/746)
A
P
G
VS
T
I
TA
D
EIR
K
N
-
PVAR
D
V
SE
I
I
R
T
-
M
PGV
N
L
TGN
S
TS
G
QR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
K
P
VSSRNS
VRQG
WR
G
E
R
D
TR
G
----
D
T
SWV
PP
-
EM
IERIEVLRGP
A
A
A
R
YGN
G
A
A
GGVVNIITKKG
S
--------------
GE
W
HG
S
WD
A
YF
N
AP
E
HK
E
E
---
G
----
AT
K
RT
NF
SLT
GPL
-
G
D
EFSF
R
LY
G
NLD
K
TQ
A
D
A
WDINQ
--
GHQSARAGTYA
T
T
L
PAGR
E
GVI
N
K
D
I
N
G
VV
--
R
W
D
F
A
P
L
Q
S
L
EL
E
AGY
SRQ
GNLYA
GDT
Q
NT
N
S
D
S
Y
TR
S
-
-KY
-----------------
G
D
E
T
N
R
L
YR
QNYSLTWNGGWDN
G
V
TTSNWVQ
Y
EH
T
R
---------
N
---------
-
S
R
---
IPE
GL
A
G
GTE
GKFNEKA
T
QDFV
DIDL
D
DVMLH
SE
V
NL
PI
DFLVNQ
T
L
T
L
G
T
EW
NQQ
R
MK
D
LSSNTQA
L
TGTNTG
G
AI
D
G
VSATDRSPYSKA
E
IF
SL
---
-
--
FAE
NNME
V
TD
S
T
I
V
T
P
G
L
R
F
--------
DH
------------
HSIV
GN
----------
N
WSP
ALN
I
SQG
L
G
D
D
F
T
LK
M
G
IA
R
A
YKAP
S
L
Y
Q
TNPNYI
L
YSKGQ
G
CYA
--
SA
G
GCY
L
-----
Q
GN
D
DLK
A
E
T
S
I
N
K
EIG
LEF-KRD
G
W
L
A
G
VT
W
F
R
N
D
YR
NKI
E
A
GYVAVGQ
N
A
VGTDLYQ
W
D
N
V
P
KA
V
VE
G
L
E
G
S
LNV
P
-
VSE
T
VMWTN
N
I
T
Y
M
-------
LK
SE
N
KT
---
T
G
D
----
RLS
I
IPEY
T
L
N
S
T
L
S
W
QAR
E
DLSMQTTF
T
WY
GK
QQ
P
KKY
-
NY
KGQP
AV
-----
G
PE
T
KEISP
Y
S
I
VGL
SAT
W
D
V
T
K
---
N
V
S
L
TGG
VDNLFDK
-
-
---R
L
WRA
G
N
AQT
TGDL
AG
ANYIA
G
A
G
A
---
Y
T
Y
NE
PGR
TW
Y
MSVN
TH
F
fig|749538.3.peg.4166
Escherichia coli MS 116-1 (47-746/746)
A
P
G
VS
T
I
TA
D
EIR
K
N
-
PVAR
D
V
SE
I
I
R
T
-
M
PGV
N
L
TGN
S
TS
G
QR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
K
P
VSSRNS
VRQG
WR
G
E
R
D
TR
G
----
D
T
SWV
PP
-
EM
IERIEVLRGP
A
A
A
R
YGN
G
A
A
GGVVNIITKKG
S
--------------
GE
W
HG
S
WD
A
YF
N
AP
E
HK
E
E
---
G
----
AT
K
RT
NF
SLT
GPL
-
G
D
EFSF
R
LY
G
NLD
K
TQ
A
D
A
WDINQ
--
GHQSARAGTYA
T
T
L
PAGR
E
GVI
N
K
D
I
N
G
VV
--
R
W
D
F
A
P
L
Q
S
L
EL
E
AGY
SRQ
GNLYA
GDT
Q
NT
N
S
D
S
Y
PR
S
-
-KY
-----------------
G
D
E
T
N
R
L
YR
QNYALTWNGGWDN
G
V
TTSNWVQ
Y
EH
T
R
---------
N
---------
-
S
R
---
IPE
GL
A
G
GTE
GKFNEKA
T
QDFV
DIDL
D
DVMLH
SE
V
NL
PI
DFLVNQ
T
L
T
L
G
T
EW
NQQ
R
MK
D
LSSNTQA
L
TGTNTG
G
AI
D
G
VSTTDRSPYSKA
E
IF
SL
---
-
--
FAE
NNME
LTD
S
T
I
V
T
P
G
L
R
F
--------
DH
------------
HSIV
GN
----------
N
WSP
ALN
I
SQG
L
G
D
D
F
T
LK
M
G
IA
R
A
YKAP
S
L
Y
Q
TNPNYI
L
YSKGQ
G
CYA
--
SA
G
GCY
L
-----
Q
GN
D
DLK
A
E
T
S
I
N
K
EIG
LEF-KRD
G
W
L
A
G
VT
W
F
R
N
D
YR
NKI
E
A
GYVAVGQ
N
A
VGTDLYQ
W
D
N
V
P
KA
V
VE
G
L
E
G
S
LNV
P
-
VSE
T
VMWTN
N
I
T
Y
M
-------
LK
SE
N
KT
---
T
G
D
----
RLS
I
IPEY
T
L
N
S
T
L
S
W
QAR
E
DLSMQTTF
T
WY
GK
QQ
P
KKY
-
NY
KGQP
AV
-----
G
PE
T
KEISP
Y
S
I
VGL
SAT
W
D
V
T
K
---
N
V
S
L
TGG
VDNLFDK
-
-
---R
L
WRA
G
N
AQT
TGDL
AG
ANYIA
G
A
G
A
---
Y
T
Y
NE
PGR
TW
Y
MSVN
TH
F
fig|656408.3.peg.516
Escherichia coli H591 (47-746/746)
A
P
G
VS
T
I
TA
D
EIR
K
N
-
PVAR
D
V
SE
I
I
R
T
-
M
PGV
N
L
TGN
S
TS
G
QR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
K
P
VSSRNS
VRQG
WR
G
E
R
D
TR
G
----
D
T
SWV
PP
-
EM
IERIEVLRGP
A
A
A
R
YGN
G
A
A
GGVVNIITKKG
S
--------------
GE
W
HG
S
WD
A
YF
N
AP
E
HK
E
E
---
G
----
AT
K
RT
NF
SLT
GPL
-
G
D
EFSF
R
LY
G
NLD
K
TQ
A
D
A
WDINQ
--
GHQSARAGTYA
T
T
L
PAGR
E
GVI
N
K
D
I
N
G
VV
--
R
W
D
F
A
P
L
Q
S
L
EL
E
AGY
SRQ
GNLYA
GDT
Q
NT
N
S
D
A
Y
TR
S
-
-KY
-----------------
G
D
E
T
N
R
L
YR
QNYALTWNGGWDN
G
V
TTSNWVQ
Y
EH
T
R
---------
N
---------
-
S
R
---
IPE
GL
A
G
GTE
GKFNEKA
T
QDFV
DIDL
D
DVMLH
SE
V
NL
PI
DFLVNQ
T
L
T
L
G
T
EW
NQQ
R
MK
D
LSSNTQA
L
TGANTG
G
AI
D
G
VSATDRSPYSKA
E
IF
SL
---
-
--
FAE
NNME
LTD
S
T
I
V
T
P
G
L
R
F
--------
DH
------------
HSIV
GN
----------
N
WSP
ALN
I
SQG
L
G
D
D
L
T
LK
M
G
IA
R
A
YKAP
S
L
Y
Q
TNPNYI
L
YSKGQ
G
CYA
--
SA
G
GCY
L
-----
Q
GN
D
DLK
A
E
T
S
I
N
K
EIG
LEF-KRD
G
W
L
A
G
VT
W
F
R
N
D
YR
NKI
E
A
GYVAVGQ
N
A
VGTDLYQ
W
D
N
V
P
KA
V
VE
G
L
E
G
S
LNV
P
-
VSE
T
VMWTN
N
I
T
Y
M
-------
LK
SE
N
KT
---
T
G
D
----
RLS
I
IPEY
T
L
N
S
T
L
S
W
QAR
E
DLSMQTTF
T
WY
GK
QQ
P
KKY
-
NY
KGQP
AV
-----
G
PE
T
KEISP
Y
S
I
VGL
SAT
W
D
V
T
K
---
N
V
S
L
TGG
VDNLFDK
-
-
---R
L
WRA
G
N
AQT
TGDL
AG
ANYIA
G
A
G
A
---
Y
T
Y
NE
PGR
TW
Y
MSVN
TH
F
fig|562.371.peg.2839
Escherichia coli 1044A (47-746/746)
A
P
G
VS
T
I
TA
D
EIR
K
N
-
PVAR
D
V
SE
I
I
R
T
-
M
PGV
N
L
TGN
S
TS
G
QR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
K
P
VSSRNS
VRQG
WR
G
E
R
D
TR
G
----
D
T
SWV
PP
-
EM
IERIEVLRGP
A
A
A
R
YGN
G
A
A
GGVVNIITKKG
S
--------------
GE
W
HG
S
WD
A
YF
N
AP
E
HK
E
E
---
G
----
AT
K
RT
NF
SLT
GPL
-
G
D
EFSF
R
LY
G
NLD
K
TQ
A
D
A
WDINQ
--
GHQSARAGTYA
T
T
L
PAGR
E
GVI
N
K
D
I
N
G
VV
--
R
W
D
F
A
P
L
Q
S
L
EL
E
AGY
SRQ
GNLYA
GDT
Q
NT
N
S
D
A
Y
TR
S
-
-KY
-----------------
G
D
E
T
N
R
L
YR
QNYSLTWNGGWDN
G
V
TTSNWVQ
Y
EH
T
R
---------
N
---------
-
S
R
---
IPE
GL
A
G
GTE
GKFNEKA
T
QDFV
DNDL
D
DVMLH
SE
V
NL
PI
DFLVNQ
T
L
T
L
G
T
EW
NQQ
R
MK
D
LSSNTQA
L
TGTNTG
G
AI
D
G
VSATDRSPYSKA
E
IF
SL
---
-
--
FAE
NNME
LTD
S
T
I
V
T
P
G
L
R
F
--------
DH
------------
HSIV
GN
----------
N
WSP
ALN
I
SQG
L
G
D
D
F
T
LK
M
G
IA
R
A
YKAP
S
L
Y
Q
TNPNYI
L
YSKGQ
G
CYA
--
SA
G
GCY
L
-----
Q
GN
D
DLK
A
E
T
S
I
N
K
EIG
LEF-KRD
G
W
L
A
G
I
T
W
F
R
N
D
YR
NKI
E
A
GYVAVGQ
N
A
VGTDLYQ
W
D
N
V
P
KA
V
VE
G
L
E
G
S
LNV
P
-
VSE
T
VMWTN
N
I
T
Y
M
-------
LK
SE
N
KT
---
T
G
D
----
RLS
I
IPEY
T
L
N
S
T
L
S
W
QAR
E
DLSMQTTF
T
WY
GK
QQ
P
KKY
-
NY
KGQP
AV
-----
G
PE
T
KEISP
Y
S
I
VGL
SAT
W
D
V
T
K
---
N
V
S
L
TGG
VDNLFDK
-
-
---R
L
WRA
G
N
AQT
TGDL
AG
ANYIA
G
A
G
A
---
Y
T
Y
NE
PGR
TW
Y
MSVN
TH
F
fig|562.373.peg.3154
Escherichia coli 1125A (47-746/746)
A
P
G
VS
T
I
TA
D
EIR
K
N
-
PVAR
D
V
SE
I
I
R
T
-
M
PGV
N
L
TGN
S
TS
G
QR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
K
P
VSSRNS
VRQG
WR
G
E
R
D
TR
G
----
D
T
SWV
PP
-
EM
IERIEVLRGP
A
A
A
R
YGN
G
A
A
GGVVNIITKKG
S
--------------
GE
W
HG
S
WD
A
YF
N
AP
E
HK
E
E
---
G
----
AT
K
RT
NF
SLT
GPL
-
G
D
EFSF
R
LY
G
NLD
K
TQ
A
D
A
WDINQ
--
GHQSARAGTYA
T
T
L
PAGR
E
GVI
N
K
D
I
N
G
VV
--
R
W
D
F
A
P
L
Q
S
L
EL
E
AGY
SRQ
GNLYA
GDT
Q
NT
N
S
D
A
Y
TR
S
-
-KY
-----------------
G
D
E
T
N
R
L
YR
QNYSLTWNGGWDN
G
V
TTSNWVQ
Y
EH
T
R
---------
N
---------
-
S
R
---
IPE
GL
A
G
GTE
GKFNEKA
T
QDFV
DNDL
D
DVMLH
SE
V
NL
PI
DFLVNQ
T
L
T
L
G
T
EW
NQQ
R
MK
D
LSSNTQA
L
TGTNTG
G
AI
D
G
VSATDRSPYSKA
E
IF
SL
---
-
--
FAE
NNME
LTD
S
T
I
V
T
P
G
L
R
F
--------
DH
------------
HSIV
GN
----------
N
WSP
ALN
I
SQG
L
G
D
D
F
T
LK
M
G
IA
R
A
YKAP
S
L
Y
Q
TNPNYI
L
YSKGQ
G
CYA
--
SA
G
GCY
L
-----
Q
GN
D
DLK
A
E
T
S
I
N
K
EIG
LEF-KRD
G
W
L
A
G
I
T
W
F
R
N
D
YR
NKI
E
A
GYVAVGQ
N
A
VGTDLYQ
W
D
N
V
P
KA
V
VE
G
L
E
G
S
LNV
P
-
VSE
T
VMWTN
N
I
T
Y
M
-------
LK
SE
N
KT
---
T
G
D
----
RLS
I
IPEY
T
L
N
S
T
L
S
W
QAR
E
DLSMQTTF
T
WY
GK
QQ
P
KKY
-
NY
KGQP
AV
-----
G
PE
T
KEISP
Y
S
I
VGL
SAT
W
D
V
T
K
---
N
V
S
L
TGG
VDNLFDK
-
-
---R
L
WRA
G
N
AQT
TGDL
AG
ANYIA
G
A
G
A
---
Y
T
Y
NE
PGR
TW
Y
MSVN
TH
F
fig|562.372.peg.1570
Escherichia coli 1212A (47-746/746)
A
P
G
VS
T
I
TA
D
EIR
K
N
-
PVAR
D
V
SE
I
I
R
T
-
M
PGV
N
L
TGN
S
TS
G
QR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
K
P
VSSRNS
VRQG
WR
G
E
R
D
TR
G
----
D
T
SWV
PP
-
EM
IERIEVLRGP
A
A
A
R
YGN
G
A
A
GGVVNIITKKG
S
--------------
GE
W
HG
S
WD
A
YF
N
AP
E
HK
E
E
---
G
----
AT
K
RT
NF
SLT
GPL
-
G
D
EFSF
R
LY
G
NLD
K
TQ
A
D
A
WDINQ
--
GHQSARAGTYA
T
T
L
PAGR
E
GVI
N
K
D
I
N
G
VV
--
R
W
D
F
A
P
L
Q
S
L
EL
E
AGY
SRQ
GNLYA
GDT
Q
NT
N
S
D
A
Y
TR
S
-
-KY
-----------------
G
D
E
T
N
R
L
YR
QNYSLTWNGGWDN
G
V
TTSNWVQ
Y
EH
T
R
---------
N
---------
-
S
R
---
IPE
GL
A
G
GTE
GKFNEKA
T
QDFV
DNDL
D
DVMLH
SE
V
NL
PI
DFLVNQ
T
L
T
L
G
T
EW
NQQ
R
MK
D
LSSNTQA
L
TGTNTG
G
AI
D
G
VSATDRSPYSKA
E
IF
SL
---
-
--
FAE
NNME
LTD
S
T
I
V
T
P
G
L
R
F
--------
DH
------------
HSIV
GN
----------
N
WSP
ALN
I
SQG
L
G
D
D
F
T
LK
M
G
IA
R
A
YKAP
S
L
Y
Q
TNPNYI
L
YSKGQ
G
CYA
--
SA
G
GCY
L
-----
Q
GN
D
DLK
A
E
T
S
I
N
K
EIG
LEF-KRD
G
W
L
A
G
I
T
W
F
R
N
D
YR
NKI
E
A
GYVAVGQ
N
A
VGTDLYQ
W
D
N
V
P
KA
V
VE
G
L
E
G
S
LNV
P
-
VSE
T
VMWTN
N
I
T
Y
M
-------
LK
SE
N
KT
---
T
G
D
----
RLS
I
IPEY
T
L
N
S
T
L
S
W
QAR
E
DLSMQTTF
T
WY
GK
QQ
P
KKY
-
NY
KGQP
AV
-----
G
PE
T
KEISP
Y
S
I
VGL
SAT
W
D
V
T
K
---
N
V
S
L
TGG
VDNLFDK
-
-
---R
L
WRA
G
N
AQT
TGDL
AG
ANYIA
G
A
G
A
---
Y
T
Y
NE
PGR
TW
Y
MSVN
TH
F
fig|562.374.peg.5408
Escherichia coli 536A (47-746/746)
A
P
G
VS
T
I
TA
D
EIR
K
N
-
PVAR
D
V
SE
I
I
R
T
-
M
PGV
N
L
TGN
S
TS
G
QR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
K
P
VSSRNS
VRQG
WR
G
E
R
D
TR
G
----
D
T
SWV
PP
-
EM
IERIEVLRGP
A
A
A
R
YGN
G
A
A
GGVVNIITKKG
S
--------------
GE
W
HG
S
WD
A
YF
N
AP
E
HK
E
E
---
G
----
AT
K
RT
NF
SLT
GPL
-
G
D
EFSF
R
LY
G
NLD
K
TQ
A
D
A
WDINQ
--
GHQSARAGTYA
T
T
L
PAGR
E
GVI
N
K
D
I
N
G
VV
--
R
W
D
F
A
P
L
Q
S
L
EL
E
AGY
SRQ
GNLYA
GDT
Q
NT
N
S
D
A
Y
TR
S
-
-KY
-----------------
G
D
E
T
N
R
L
YR
QNYSLTWNGGWDN
G
V
TTSNWVQ
Y
EH
T
R
---------
N
---------
-
S
R
---
IPE
GL
A
G
GTE
GKFNEKA
T
QDFV
DNDL
D
DVMLH
SE
V
NL
PI
DFLVNQ
T
L
T
L
G
T
EW
NQQ
R
MK
D
LSSNTQA
L
TGTNTG
G
AI
D
G
VSATDRSPYSKA
E
IF
SL
---
-
--
FAE
NNME
LTD
S
T
I
V
T
P
G
L
R
F
--------
DH
------------
HSIV
GN
----------
N
WSP
ALN
I
SQG
L
G
D
D
F
T
LK
M
G
IA
R
A
YKAP
S
L
Y
Q
TNPNYI
L
YSKGQ
G
CYA
--
SA
G
GCY
L
-----
Q
GN
D
DLK
A
E
T
S
I
N
K
EIG
LEF-KRD
G
W
L
A
G
I
T
W
F
R
N
D
YR
NKI
E
A
GYVAVGQ
N
A
VGTDLYQ
W
D
N
V
P
KA
V
VE
G
L
E
G
S
LNV
P
-
VSE
T
VMWTN
N
I
T
Y
M
-------
LK
SE
N
KT
---
T
G
D
----
RLS
I
IPEY
T
L
N
S
T
L
S
W
QAR
E
DLSMQTTF
T
WY
GK
QQ
P
KKY
-
NY
KGQP
AV
-----
G
PE
T
KEISP
Y
S
I
VGL
SAT
W
D
V
T
K
---
N
V
S
L
TGG
VDNLFDK
-
-
---R
L
WRA
G
N
AQT
TGDL
AG
ANYIA
G
A
G
A
---
Y
T
Y
NE
PGR
TW
Y
MSVN
TH
F
fig|83334.1.peg.696
Escherichia coli O157:H7 (47-746/746)
A
P
G
VS
T
I
TA
D
EIR
K
N
-
PVAR
D
V
SE
I
I
R
T
-
M
PGV
N
L
TGN
S
TS
G
QR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
K
P
VSSRNS
VRQG
WR
G
E
R
D
TR
G
----
D
T
SWV
PP
-
EM
IERIEVLRGP
A
A
A
R
YGN
G
A
A
GGVVNIITKKG
S
--------------
GE
W
HG
S
WD
A
YF
N
AP
E
HK
E
E
---
G
----
AT
K
RT
NF
SLT
GPL
-
G
D
EFSF
R
LY
G
NLD
K
TQ
A
D
A
WDINQ
--
GHQSARAGTYA
T
T
L
PAGR
E
GVI
N
K
D
I
N
G
VV
--
R
W
D
F
A
P
L
Q
S
L
EL
E
AGY
SRQ
GNLYA
GDT
Q
NT
N
S
D
A
Y
TR
S
-
-KY
-----------------
G
D
E
T
N
R
L
YR
QNYSLTWNGGWDN
G
V
TTSNWVQ
Y
EH
T
R
---------
N
---------
-
S
R
---
IPE
GL
A
G
GTE
GKFNEKA
T
QDFV
DNDL
D
DVMLH
SE
V
NL
PI
DFLVNQ
T
L
T
L
G
T
EW
NQQ
R
MK
D
LSSNTQA
L
TGTNTG
G
AI
D
G
VSATDRSPYSKA
E
IF
SL
---
-
--
FAE
NNME
LTD
S
T
I
V
T
P
G
L
R
F
--------
DH
------------
HSIV
GN
----------
N
WSP
ALN
I
SQG
L
G
D
D
F
T
LK
M
G
IA
R
A
YKAP
S
L
Y
Q
TNPNYI
L
YSKGQ
G
CYA
--
SA
G
GCY
L
-----
Q
GN
D
DLK
A
E
T
S
I
N
K
EIG
LEF-KRD
G
W
L
A
G
I
T
W
F
R
N
D
YR
NKI
E
A
GYVAVGQ
N
A
VGTDLYQ
W
D
N
V
P
KA
V
VE
G
L
E
G
S
LNV
P
-
VSE
T
VMWTN
N
I
T
Y
M
-------
LK
SE
N
KT
---
T
G
D
----
RLS
I
IPEY
T
L
N
S
T
L
S
W
QAR
E
DLSMQTTF
T
WY
GK
QQ
P
KKY
-
NY
KGQP
AV
-----
G
PE
T
KEISP
Y
S
I
VGL
SAT
W
D
V
T
K
---
N
V
S
L
TGG
VDNLFDK
-
-
---R
L
WRA
G
N
AQT
TGDL
AG
ANYIA
G
A
G
A
---
Y
T
Y
NE
PGR
TW
Y
MSVN
TH
F
fig|155864.1.peg.618
Escherichia coli O157:H7 EDL933 (47-746/746)
A
P
G
VS
T
I
TA
D
EIR
K
N
-
PVAR
D
V
SE
I
I
R
T
-
M
PGV
N
L
TGN
S
TS
G
QR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
K
P
VSSRNS
VRQG
WR
G
E
R
D
TR
G
----
D
T
SWV
PP
-
EM
IERIEVLRGP
A
A
A
R
YGN
G
A
A
GGVVNIITKKG
S
--------------
GE
W
HG
S
WD
A
YF
N
AP
E
HK
E
E
---
G
----
AT
K
RT
NF
SLT
GPL
-
G
D
EFSF
R
LY
G
NLD
K
TQ
A
D
A
WDINQ
--
GHQSARAGTYA
T
T
L
PAGR
E
GVI
N
K
D
I
N
G
VV
--
R
W
D
F
A
P
L
Q
S
L
EL
E
AGY
SRQ
GNLYA
GDT
Q
NT
N
S
D
A
Y
TR
S
-
-KY
-----------------
G
D
E
T
N
R
L
YR
QNYSLTWNGGWDN
G
V
TTSNWVQ
Y
EH
T
R
---------
N
---------
-
S
R
---
IPE
GL
A
G
GTE
GKFNEKA
T
QDFV
DNDL
D
DVMLH
SE
V
NL
PI
DFLVNQ
T
L
T
L
G
T
EW
NQQ
R
MK
D
LSSNTQA
L
TGTNTG
G
AI
D
G
VSATDRSPYSKA
E
IF
SL
---
-
--
FAE
NNME
LTD
S
T
I
V
T
P
G
L
R
F
--------
DH
------------
HSIV
GN
----------
N
WSP
ALN
I
SQG
L
G
D
D
F
T
LK
M
G
IA
R
A
YKAP
S
L
Y
Q
TNPNYI
L
YSKGQ
G
CYA
--
SA
G
GCY
L
-----
Q
GN
D
DLK
A
E
T
S
I
N
K
EIG
LEF-KRD
G
W
L
A
G
I
T
W
F
R
N
D
YR
NKI
E
A
GYVAVGQ
N
A
VGTDLYQ
W
D
N
V
P
KA
V
VE
G
L
E
G
S
LNV
P
-
VSE
T
VMWTN
N
I
T
Y
M
-------
LK
SE
N
KT
---
T
G
D
----
RLS
I
IPEY
T
L
N
S
T
L
S
W
QAR
E
DLSMQTTF
T
WY
GK
QQ
P
KKY
-
NY
KGQP
AV
-----
G
PE
T
KEISP
Y
S
I
VGL
SAT
W
D
V
T
K
---
N
V
S
L
TGG
VDNLFDK
-
-
---R
L
WRA
G
N
AQT
TGDL
AG
ANYIA
G
A
G
A
---
Y
T
Y
NE
PGR
TW
Y
MSVN
TH
F
fig|155864.8.peg.633
Escherichia coli O157:H7 EDL933 (47-746/746)
A
P
G
VS
T
I
TA
D
EIR
K
N
-
PVAR
D
V
SE
I
I
R
T
-
M
PGV
N
L
TGN
S
TS
G
QR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
K
P
VSSRNS
VRQG
WR
G
E
R
D
TR
G
----
D
T
SWV
PP
-
EM
IERIEVLRGP
A
A
A
R
YGN
G
A
A
GGVVNIITKKG
S
--------------
GE
W
HG
S
WD
A
YF
N
AP
E
HK
E
E
---
G
----
AT
K
RT
NF
SLT
GPL
-
G
D
EFSF
R
LY
G
NLD
K
TQ
A
D
A
WDINQ
--
GHQSARAGTYA
T
T
L
PAGR
E
GVI
N
K
D
I
N
G
VV
--
R
W
D
F
A
P
L
Q
S
L
EL
E
AGY
SRQ
GNLYA
GDT
Q
NT
N
S
D
A
Y
TR
S
-
-KY
-----------------
G
D
E
T
N
R
L
YR
QNYSLTWNGGWDN
G
V
TTSNWVQ
Y
EH
T
R
---------
N
---------
-
S
R
---
IPE
GL
A
G
GTE
GKFNEKA
T
QDFV
DNDL
D
DVMLH
SE
V
NL
PI
DFLVNQ
T
L
T
L
G
T
EW
NQQ
R
MK
D
LSSNTQA
L
TGTNTG
G
AI
D
G
VSATDRSPYSKA
E
IF
SL
---
-
--
FAE
NNME
LTD
S
T
I
V
T
P
G
L
R
F
--------
DH
------------
HSIV
GN
----------
N
WSP
ALN
I
SQG
L
G
D
D
F
T
LK
M
G
IA
R
A
YKAP
S
L
Y
Q
TNPNYI
L
YSKGQ
G
CYA
--
SA
G
GCY
L
-----
Q
GN
D
DLK
A
E
T
S
I
N
K
EIG
LEF-KRD
G
W
L
A
G
I
T
W
F
R
N
D
YR
NKI
E
A
GYVAVGQ
N
A
VGTDLYQ
W
D
N
V
P
KA
V
VE
G
L
E
G
S
LNV
P
-
VSE
T
VMWTN
N
I
T
Y
M
-------
LK
SE
N
KT
---
T
G
D
----
RLS
I
IPEY
T
L
N
S
T
L
S
W
QAR
E
DLSMQTTF
T
WY
GK
QQ
P
KKY
-
NY
KGQP
AV
-----
G
PE
T
KEISP
Y
S
I
VGL
SAT
W
D
V
T
K
---
N
V
S
L
TGG
VDNLFDK
-
-
---R
L
WRA
G
N
AQT
TGDL
AG
ANYIA
G
A
G
A
---
Y
T
Y
NE
PGR
TW
Y
MSVN
TH
F
fig|444454.5.peg.5108
Escherichia coli O157:H7 str. EC4024 (47-746/746)
A
P
G
VS
T
I
TA
D
EIR
K
N
-
PVAR
D
V
SE
I
I
R
T
-
M
PGV
N
L
TGN
S
TS
G
QR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
K
P
VSSRNS
VRQG
WR
G
E
R
D
TR
G
----
D
T
SWV
PP
-
EM
IERIEVLRGP
A
A
A
R
YGN
G
A
A
GGVVNIITKKG
S
--------------
GE
W
HG
S
WD
A
YF
N
AP
E
HK
E
E
---
G
----
AT
K
RT
NF
SLT
GPL
-
G
D
EFSF
R
LY
G
NLD
K
TQ
A
D
A
WDINQ
--
GHQSARAGTYA
T
T
L
PAGR
E
GVI
N
K
D
I
N
G
VV
--
R
W
D
F
A
P
L
Q
S
L
EL
E
AGY
SRQ
GNLYA
GDT
Q
NT
N
S
D
A
Y
TR
S
-
-KY
-----------------
G
D
E
T
N
R
L
YR
QNYSLTWNGGWDN
G
V
TTSNWVQ
Y
EH
T
R
---------
N
---------
-
S
R
---
IPE
GL
A
G
GTE
GKFNEKA
T
QDFV
DNDL
D
DVMLH
SE
V
NL
PI
DFLVNQ
T
L
T
L
G
T
EW
NQQ
R
MK
D
LSSNTQA
L
TGTNTG
G
AI
D
G
VSATDRSPYSKA
E
IF
SL
---
-
--
FAE
NNME
LTD
S
T
I
V
T
P
G
L
R
F
--------
DH
------------
HSIV
GN
----------
N
WSP
ALN
I
SQG
L
G
D
D
F
T
LK
M
G
IA
R
A
YKAP
S
L
Y
Q
TNPNYI
L
YSKGQ
G
CYA
--
SA
G
GCY
L
-----
Q
GN
D
DLK
A
E
T
S
I
N
K
EIG
LEF-KRD
G
W
L
A
G
I
T
W
F
R
N
D
YR
NKI
E
A
GYVAVGQ
N
A
VGTDLYQ
W
D
N
V
P
KA
V
VE
G
L
E
G
S
LNV
P
-
VSE
T
VMWTN
N
I
T
Y
M
-------
LK
SE
N
KT
---
T
G
D
----
RLS
I
IPEY
T
L
N
S
T
L
S
W
QAR
E
DLSMQTTF
T
WY
GK
QQ
P
KKY
-
NY
KGQP
AV
-----
G
PE
T
KEISP
Y
S
I
VGL
SAT
W
D
V
T
K
---
N
V
S
L
TGG
VDNLFDK
-
-
---R
L
WRA
G
N
AQT
TGDL
AG
ANYIA
G
A
G
A
---
Y
T
Y
NE
PGR
TW
Y
MSVN
TH
F
fig|444449.5.peg.5444
Escherichia coli O157:H7 str. EC4042 (47-746/746)
A
P
G
VS
T
I
TA
D
EIR
K
N
-
PVAR
D
V
SE
I
I
R
T
-
M
PGV
N
L
TGN
S
TS
G
QR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
K
P
VSSRNS
VRQG
WR
G
E
R
D
TR
G
----
D
T
SWV
PP
-
EM
IERIEVLRGP
A
A
A
R
YGN
G
A
A
GGVVNIITKKG
S
--------------
GE
W
HG
S
WD
A
YF
N
AP
E
HK
E
E
---
G
----
AT
K
RT
NF
SLT
GPL
-
G
D
EFSF
R
LY
G
NLD
K
TQ
A
D
A
WDINQ
--
GHQSARAGTYA
T
T
L
PAGR
E
GVI
N
K
D
I
N
G
VV
--
R
W
D
F
A
P
L
Q
S
L
EL
E
AGY
SRQ
GNLYA
GDT
Q
NT
N
S
D
A
Y
TR
S
-
-KY
-----------------
G
D
E
T
N
R
L
YR
QNYSLTWNGGWDN
G
V
TTSNWVQ
Y
EH
T
R
---------
N
---------
-
S
R
---
IPE
GL
A
G
GTE
GKFNEKA
T
QDFV
DNDL
D
DVMLH
SE
V
NL
PI
DFLVNQ
T
L
T
L
G
T
EW
NQQ
R
MK
D
LSSNTQA
L
TGTNTG
G
AI
D
G
VSATDRSPYSKA
E
IF
SL
---
-
--
FAE
NNME
LTD
S
T
I
V
T
P
G
L
R
F
--------
DH
------------
HSIV
GN
----------
N
WSP
ALN
I
SQG
L
G
D
D
F
T
LK
M
G
IA
R
A
YKAP
S
L
Y
Q
TNPNYI
L
YSKGQ
G
CYA
--
SA
G
GCY
L
-----
Q
GN
D
DLK
A
E
T
S
I
N
K
EIG
LEF-KRD
G
W
L
A
G
I
T
W
F
R
N
D
YR
NKI
E
A
GYVAVGQ
N
A
VGTDLYQ
W
D
N
V
P
KA
V
VE
G
L
E
G
S
LNV
P
-
VSE
T
VMWTN
N
I
T
Y
M
-------
LK
SE
N
KT
---
T
G
D
----
RLS
I
IPEY
T
L
N
S
T
L
S
W
QAR
E
DLSMQTTF
T
WY
GK
QQ
P
KKY
-
NY
KGQP
AV
-----
G
PE
T
KEISP
Y
S
I
VGL
SAT
W
D
V
T
K
---
N
V
S
L
TGG
VDNLFDK
-
-
---R
L
WRA
G
N
AQT
TGDL
AG
ANYIA
G
A
G
A
---
Y
T
Y
NE
PGR
TW
Y
MSVN
TH
F
fig|444448.5.peg.3318
Escherichia coli O157:H7 str. EC4045 (47-746/746)
A
P
G
VS
T
I
TA
D
EIR
K
N
-
PVAR
D
V
SE
I
I
R
T
-
M
PGV
N
L
TGN
S
TS
G
QR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
K
P
VSSRNS
VRQG
WR
G
E
R
D
TR
G
----
D
T
SWV
PP
-
EM
IERIEVLRGP
A
A
A
R
YGN
G
A
A
GGVVNIITKKG
S
--------------
GE
W
HG
S
WD
A
YF
N
AP
E
HK
E
E
---
G
----
AT
K
RT
NF
SLT
GPL
-
G
D
EFSF
R
LY
G
NLD
K
TQ
A
D
A
WDINQ
--
GHQSARAGTYA
T
T
L
PAGR
E
GVI
N
K
D
I
N
G
VV
--
R
W
D
F
A
P
L
Q
S
L
EL
E
AGY
SRQ
GNLYA
GDT
Q
NT
N
S
D
A
Y
TR
S
-
-KY
-----------------
G
D
E
T
N
R
L
YR
QNYSLTWNGGWDN
G
V
TTSNWVQ
Y
EH
T
R
---------
N
---------
-
S
R
---
IPE
GL
A
G
GTE
GKFNEKA
T
QDFV
DNDL
D
DVMLH
SE
V
NL
PI
DFLVNQ
T
L
T
L
G
T
EW
NQQ
R
MK
D
LSSNTQA
L
TGTNTG
G
AI
D
G
VSATDRSPYSKA
E
IF
SL
---
-
--
FAE
NNME
LTD
S
T
I
V
T
P
G
L
R
F
--------
DH
------------
HSIV
GN
----------
N
WSP
ALN
I
SQG
L
G
D
D
F
T
LK
M
G
IA
R
A
YKAP
S
L
Y
Q
TNPNYI
L
YSKGQ
G
CYA
--
SA
G
GCY
L
-----
Q
GN
D
DLK
A
E
T
S
I
N
K
EIG
LEF-KRD
G
W
L
A
G
I
T
W
F
R
N
D
YR
NKI
E
A
GYVAVGQ
N
A
VGTDLYQ
W
D
N
V
P
KA
V
VE
G
L
E
G
S
LNV
P
-
VSE
T
VMWTN
N
I
T
Y
M
-------
LK
SE
N
KT
---
T
G
D
----
RLS
I
IPEY
T
L
N
S
T
L
S
W
QAR
E
DLSMQTTF
T
WY
GK
QQ
P
KKY
-
NY
KGQP
AV
-----
G
PE
T
KEISP
Y
S
I
VGL
SAT
W
D
V
T
K
---
N
V
S
L
TGG
VDNLFDK
-
-
---R
L
WRA
G
N
AQT
TGDL
AG
ANYIA
G
A
G
A
---
Y
T
Y
NE
PGR
TW
Y
MSVN
TH
F
fig|444453.5.peg.660
Escherichia coli O157:H7 str. EC4076 (47-746/746)
A
P
G
VS
T
I
TA
D
EIR
K
N
-
PVAR
D
V
SE
I
I
R
T
-
M
PGV
N
L
TGN
S
TS
G
QR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
K
P
VSSRNS
VRQG
WR
G
E
R
D
TR
G
----
D
T
SWV
PP
-
EM
IERIEVLRGP
A
A
A
R
YGN
G
A
A
GGVVNIITKKG
S
--------------
GE
W
HG
S
WD
A
YF
N
AP
E
HK
E
E
---
G
----
AT
K
RT
NF
SLT
GPL
-
G
D
EFSF
R
LY
G
NLD
K
TQ
A
D
A
WDINQ
--
GHQSARAGTYA
T
T
L
PAGR
E
GVI
N
K
D
I
N
G
VV
--
R
W
D
F
A
P
L
Q
S
L
EL
E
AGY
SRQ
GNLYA
GDT
Q
NT
N
S
D
A
Y
TR
S
-
-KY
-----------------
G
D
E
T
N
R
L
YR
QNYSLTWNGGWDN
G
V
TTSNWVQ
Y
EH
T
R
---------
N
---------
-
S
R
---
IPE
GL
A
G
GTE
GKFNEKA
T
QDFV
DNDL
D
DVMLH
SE
V
NL
PI
DFLVNQ
T
L
T
L
G
T
EW
NQQ
R
MK
D
LSSNTQA
L
TGTNTG
G
AI
D
G
VSATDRSPYSKA
E
IF
SL
---
-
--
FAE
NNME
LTD
S
T
I
V
T
P
G
L
R
F
--------
DH
------------
HSIV
GN
----------
N
WSP
ALN
I
SQG
L
G
D
D
F
T
LK
M
G
IA
R
A
YKAP
S
L
Y
Q
TNPNYI
L
YSKGQ
G
CYA
--
SA
G
GCY
L
-----
Q
GN
D
DLK
A
E
T
S
I
N
K
EIG
LEF-KRD
G
W
L
A
G
I
T
W
F
R
N
D
YR
NKI
E
A
GYVAVGQ
N
A
VGTDLYQ
W
D
N
V
P
KA
V
VE
G
L
E
G
S
LNV
P
-
VSE
T
VMWTN
N
I
T
Y
M
-------
LK
SE
N
KT
---
T
G
D
----
RLS
I
IPEY
T
L
N
S
T
L
S
W
QAR
E
DLSMQTTF
T
WY
GK
QQ
P
KKY
-
NY
KGQP
AV
-----
G
PE
T
KEISP
Y
S
I
VGL
SAT
W
D
V
T
K
---
N
V
S
L
TGG
VDNLFDK
-
-
---R
L
WRA
G
N
AQT
TGDL
AG
ANYIA
G
A
G
A
---
Y
T
Y
NE
PGR
TW
Y
MSVN
TH
F
fig|444452.5.peg.868
Escherichia coli O157:H7 str. EC4113 (47-746/746)
A
P
G
VS
T
I
TA
D
EIR
K
N
-
PVAR
D
V
SE
I
I
R
T
-
M
PGV
N
L
TGN
S
TS
G
QR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
K
P
VSSRNS
VRQG
WR
G
E
R
D
TR
G
----
D
T
SWV
PP
-
EM
IERIEVLRGP
A
A
A
R
YGN
G
A
A
GGVVNIITKKG
S
--------------
GE
W
HG
S
WD
A
YF
N
AP
E
HK
E
E
---
G
----
AT
K
RT
NF
SLT
GPL
-
G
D
EFSF
R
LY
G
NLD
K
TQ
A
D
A
WDINQ
--
GHQSARAGTYA
T
T
L
PAGR
E
GVI
N
K
D
I
N
G
VV
--
R
W
D
F
A
P
L
Q
S
L
EL
E
AGY
SRQ
GNLYA
GDT
Q
NT
N
S
D
A
Y
TR
S
-
-KY
-----------------
G
D
E
T
N
R
L
YR
QNYSLTWNGGWDN
G
V
TTSNWVQ
Y
EH
T
R
---------
N
---------
-
S
R
---
IPE
GL
A
G
GTE
GKFNEKA
T
QDFV
DNDL
D
DVMLH
SE
V
NL
PI
DFLVNQ
T
L
T
L
G
T
EW
NQQ
R
MK
D
LSSNTQA
L
TGTNTG
G
AI
D
G
VSATDRSPYSKA
E
IF
SL
---
-
--
FAE
NNME
LTD
S
T
I
V
T
P
G
L
R
F
--------
DH
------------
HSIV
GN
----------
N
WSP
ALN
I
SQG
L
G
D
D
F
T
LK
M
G
IA
R
A
YKAP
S
L
Y
Q
TNPNYI
L
YSKGQ
G
CYA
--
SA
G
GCY
L
-----
Q
GN
D
DLK
A
E
T
S
I
N
K
EIG
LEF-KRD
G
W
L
A
G
I
T
W
F
R
N
D
YR
NKI
E
A
GYVAVGQ
N
A
VGTDLYQ
W
D
N
V
P
KA
V
VE
G
L
E
G
S
LNV
P
-
VSE
T
VMWTN
N
I
T
Y
M
-------
LK
SE
N
KT
---
T
G
D
----
RLS
I
IPEY
T
L
N
S
T
L
S
W
QAR
E
DLSMQTTF
T
WY
GK
QQ
P
KKY
-
NY
KGQP
AV
-----
G
PE
T
KEISP
Y
S
I
VGL
SAT
W
D
V
T
K
---
N
V
S
L
TGG
VDNLFDK
-
-
---R
L
WRA
G
N
AQT
TGDL
AG
ANYIA
G
A
G
A
---
Y
T
Y
NE
PGR
TW
Y
MSVN
TH
F
fig|444450.8.peg.778
Escherichia coli O157:H7 str. EC4115 (47-746/746)
A
P
G
VS
T
I
TA
D
EIR
K
N
-
PVAR
D
V
SE
I
I
R
T
-
M
PGV
N
L
TGN
S
TS
G
QR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
K
P
VSSRNS
VRQG
WR
G
E
R
D
TR
G
----
D
T
SWV
PP
-
EM
IERIEVLRGP
A
A
A
R
YGN
G
A
A
GGVVNIITKKG
S
--------------
GE
W
HG
S
WD
A
YF
N
AP
E
HK
E
E
---
G
----
AT
K
RT
NF
SLT
GPL
-
G
D
EFSF
R
LY
G
NLD
K
TQ
A
D
A
WDINQ
--
GHQSARAGTYA
T
T
L
PAGR
E
GVI
N
K
D
I
N
G
VV
--
R
W
D
F
A
P
L
Q
S
L
EL
E
AGY
SRQ
GNLYA
GDT
Q
NT
N
S
D
A
Y
TR
S
-
-KY
-----------------
G
D
E
T
N
R
L
YR
QNYSLTWNGGWDN
G
V
TTSNWVQ
Y
EH
T
R
---------
N
---------
-
S
R
---
IPE
GL
A
G
GTE
GKFNEKA
T
QDFV
DNDL
D
DVMLH
SE
V
NL
PI
DFLVNQ
T
L
T
L
G
T
EW
NQQ
R
MK
D
LSSNTQA
L
TGTNTG
G
AI
D
G
VSATDRSPYSKA
E
IF
SL
---
-
--
FAE
NNME
LTD
S
T
I
V
T
P
G
L
R
F
--------
DH
------------
HSIV
GN
----------
N
WSP
ALN
I
SQG
L
G
D
D
F
T
LK
M
G
IA
R
A
YKAP
S
L
Y
Q
TNPNYI
L
YSKGQ
G
CYA
--
SA
G
GCY
L
-----
Q
GN
D
DLK
A
E
T
S
I
N
K
EIG
LEF-KRD
G
W
L
A
G
I
T
W
F
R
N
D
YR
NKI
E
A
GYVAVGQ
N
A
VGTDLYQ
W
D
N
V
P
KA
V
VE
G
L
E
G
S
LNV
P
-
VSE
T
VMWTN
N
I
T
Y
M
-------
LK
SE
N
KT
---
T
G
D
----
RLS
I
IPEY
T
L
N
S
T
L
S
W
QAR
E
DLSMQTTF
T
WY
GK
QQ
P
KKY
-
NY
KGQP
AV
-----
G
PE
T
KEISP
Y
S
I
VGL
SAT
W
D
V
T
K
---
N
V
S
L
TGG
VDNLFDK
-
-
---R
L
WRA
G
N
AQT
TGDL
AG
ANYIA
G
A
G
A
---
Y
T
Y
NE
PGR
TW
Y
MSVN
TH
F
fig|444451.5.peg.2280
Escherichia coli O157:H7 str. EC4196 (47-746/746)
A
P
G
VS
T
I
TA
D
EIR
K
N
-
PVAR
D
V
SE
I
I
R
T
-
M
PGV
N
L
TGN
S
TS
G
QR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
K
P
VSSRNS
VRQG
WR
G
E
R
D
TR
G
----
D
T
SWV
PP
-
EM
IERIEVLRGP
A
A
A
R
YGN
G
A
A
GGVVNIITKKG
S
--------------
GE
W
HG
S
WD
A
YF
N
AP
E
HK
E
E
---
G
----
AT
K
RT
NF
SLT
GPL
-
G
D
EFSF
R
LY
G
NLD
K
TQ
A
D
A
WDINQ
--
GHQSARAGTYA
T
T
L
PAGR
E
GVI
N
K
D
I
N
G
VV
--
R
W
D
F
A
P
L
Q
S
L
EL
E
AGY
SRQ
GNLYA
GDT
Q
NT
N
S
D
A
Y
TR
S
-
-KY
-----------------
G
D
E
T
N
R
L
YR
QNYSLTWNGGWDN
G
V
TTSNWVQ
Y
EH
T
R
---------
N
---------
-
S
R
---
IPE
GL
A
G
GTE
GKFNEKA
T
QDFV
DNDL
D
DVMLH
SE
V
NL
PI
DFLVNQ
T
L
T
L
G
T
EW
NQQ
R
MK
D
LSSNTQA
L
TGTNTG
G
AI
D
G
VSATDRSPYSKA
E
IF
SL
---
-
--
FAE
NNME
LTD
S
T
I
V
T
P
G
L
R
F
--------
DH
------------
HSIV
GN
----------
N
WSP
ALN
I
SQG
L
G
D
D
F
T
LK
M
G
IA
R
A
YKAP
S
L
Y
Q
TNPNYI
L
YSKGQ
G
CYA
--
SA
G
GCY
L
-----
Q
GN
D
DLK
A
E
T
S
I
N
K
EIG
LEF-KRD
G
W
L
A
G
I
T
W
F
R
N
D
YR
NKI
E
A
GYVAVGQ
N
A
VGTDLYQ
W
D
N
V
P
KA
V
VE
G
L
E
G
S
LNV
P
-
VSE
T
VMWTN
N
I
T
Y
M
-------
LK
SE
N
KT
---
T
G
D
----
RLS
I
IPEY
T
L
N
S
T
L
S
W
QAR
E
DLSMQTTF
T
WY
GK
QQ
P
KKY
-
NY
KGQP
AV
-----
G
PE
T
KEISP
Y
S
I
VGL
SAT
W
D
V
T
K
---
N
V
S
L
TGG
VDNLFDK
-
-
---R
L
WRA
G
N
AQT
TGDL
AG
ANYIA
G
A
G
A
---
Y
T
Y
NE
PGR
TW
Y
MSVN
TH
F
fig|444447.5.peg.3493
Escherichia coli O157:H7 str. EC4206 (47-746/746)
A
P
G
VS
T
I
TA
D
EIR
K
N
-
PVAR
D
V
SE
I
I
R
T
-
M
PGV
N
L
TGN
S
TS
G
QR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
K
P
VSSRNS
VRQG
WR
G
E
R
D
TR
G
----
D
T
SWV
PP
-
EM
IERIEVLRGP
A
A
A
R
YGN
G
A
A
GGVVNIITKKG
S
--------------
GE
W
HG
S
WD
A
YF
N
AP
E
HK
E
E
---
G
----
AT
K
RT
NF
SLT
GPL
-
G
D
EFSF
R
LY
G
NLD
K
TQ
A
D
A
WDINQ
--
GHQSARAGTYA
T
T
L
PAGR
E
GVI
N
K
D
I
N
G
VV
--
R
W
D
F
A
P
L
Q
S
L
EL
E
AGY
SRQ
GNLYA
GDT
Q
NT
N
S
D
A
Y
TR
S
-
-KY
-----------------
G
D
E
T
N
R
L
YR
QNYSLTWNGGWDN
G
V
TTSNWVQ
Y
EH
T
R
---------
N
---------
-
S
R
---
IPE
GL
A
G
GTE
GKFNEKA
T
QDFV
DNDL
D
DVMLH
SE
V
NL
PI
DFLVNQ
T
L
T
L
G
T
EW
NQQ
R
MK
D
LSSNTQA
L
TGTNTG
G
AI
D
G
VSATDRSPYSKA
E
IF
SL
---
-
--
FAE
NNME
LTD
S
T
I
V
T
P
G
L
R
F
--------
DH
------------
HSIV
GN
----------
N
WSP
ALN
I
SQG
L
G
D
D
F
T
LK
M
G
IA
R
A
YKAP
S
L
Y
Q
TNPNYI
L
YSKGQ
G
CYA
--
SA
G
GCY
L
-----
Q
GN
D
DLK
A
E
T
S
I
N
K
EIG
LEF-KRD
G
W
L
A
G
I
T
W
F
R
N
D
YR
NKI
E
A
GYVAVGQ
N
A
VGTDLYQ
W
D
N
V
P
KA
V
VE
G
L
E
G
S
LNV
P
-
VSE
T
VMWTN
N
I
T
Y
M
-------
LK
SE
N
KT
---
T
G
D
----
RLS
I
IPEY
T
L
N
S
T
L
S
W
QAR
E
DLSMQTTF
T
WY
GK
QQ
P
KKY
-
NY
KGQP
AV
-----
G
PE
T
KEISP
Y
S
I
VGL
SAT
W
D
V
T
K
---
N
V
S
L
TGG
VDNLFDK
-
-
---R
L
WRA
G
N
AQT
TGDL
AG
ANYIA
G
A
G
A
---
Y
T
Y
NE
PGR
TW
Y
MSVN
TH
F
fig|478004.5.peg.1486
Escherichia coli O157:H7 str. EC4401 (47-746/746)
A
P
G
VS
T
I
TA
D
EIR
K
N
-
PVAR
D
V
SE
I
I
R
T
-
M
PGV
N
L
TGN
S
TS
G
QR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
K
P
VSSRNS
VRQG
WR
G
E
R
D
TR
G
----
D
T
SWV
PP
-
EM
IERIEVLRGP
A
A
A
R
YGN
G
A
A
GGVVNIITKKG
S
--------------
GE
W
HG
S
WD
A
YF
N
AP
E
HK
E
E
---
G
----
AT
K
RT
NF
SLT
GPL
-
G
D
EFSF
R
LY
G
NLD
K
TQ
A
D
A
WDINQ
--
GHQSARAGTYA
T
T
L
PAGR
E
GVI
N
K
D
I
N
G
VV
--
R
W
D
F
A
P
L
Q
S
L
EL
E
AGY
SRQ
GNLYA
GDT
Q
NT
N
S
D
A
Y
TR
S
-
-KY
-----------------
G
D
E
T
N
R
L
YR
QNYSLTWNGGWDN
G
V
TTSNWVQ
Y
EH
T
R
---------
N
---------
-
S
R
---
IPE
GL
A
G
GTE
GKFNEKA
T
QDFV
DNDL
D
DVMLH
SE
V
NL
PI
DFLVNQ
T
L
T
L
G
T
EW
NQQ
R
MK
D
LSSNTQA
L
TGTNTG
G
AI
D
G
VSATDRSPYSKA
E
IF
SL
---
-
--
FAE
NNME
LTD
S
T
I
V
T
P
G
L
R
F
--------
DH
------------
HSIV
GN
----------
N
WSP
ALN
I
SQG
L
G
D
D
F
T
LK
M
G
IA
R
A
YKAP
S
L
Y
Q
TNPNYI
L
YSKGQ
G
CYA
--
SA
G
GCY
L
-----
Q
GN
D
DLK
A
E
T
S
I
N
K
EIG
LEF-KRD
G
W
L
A
G
I
T
W
F
R
N
D
YR
NKI
E
A
GYVAVGQ
N
A
VGTDLYQ
W
D
N
V
P
KA
V
VE
G
L
E
G
S
LNV
P
-
VSE
T
VMWTN
N
I
T
Y
M
-------
LK
SE
N
KT
---
T
G
D
----
RLS
I
IPEY
T
L
N
S
T
L
S
W
QAR
E
DLSMQTTF
T
WY
GK
QQ
P
KKY
-
NY
KGQP
AV
-----
G
PE
T
KEISP
Y
S
I
VGL
SAT
W
D
V
T
K
---
N
V
S
L
TGG
VDNLFDK
-
-
---R
L
WRA
G
N
AQT
TGDL
AG
ANYIA
G
A
G
A
---
Y
T
Y
NE
PGR
TW
Y
MSVN
TH
F
fig|478005.5.peg.3996
Escherichia coli O157:H7 str. EC4486 (47-746/746)
A
P
G
VS
T
I
TA
D
EIR
K
N
-
PVAR
D
V
SE
I
I
R
T
-
M
PGV
N
L
TGN
S
TS
G
QR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
K
P
VSSRNS
VRQG
WR
G
E
R
D
TR
G
----
D
T
SWV
PP
-
EM
IERIEVLRGP
A
A
A
R
YGN
G
A
A
GGVVNIITKKG
S
--------------
GE
W
HG
S
WD
A
YF
N
AP
E
HK
E
E
---
G
----
AT
K
RT
NF
SLT
GPL
-
G
D
EFSF
R
LY
G
NLD
K
TQ
A
D
A
WDINQ
--
GHQSARAGTYA
T
T
L
PAGR
E
GVI
N
K
D
I
N
G
VV
--
R
W
D
F
A
P
L
Q
S
L
EL
E
AGY
SRQ
GNLYA
GDT
Q
NT
N
S
D
A
Y
TR
S
-
-KY
-----------------
G
D
E
T
N
R
L
YR
QNYSLTWNGGWDN
G
V
TTSNWVQ
Y
EH
T
R
---------
N
---------
-
S
R
---
IPE
GL
A
G
GTE
GKFNEKA
T
QDFV
DNDL
D
DVMLH
SE
V
NL
PI
DFLVNQ
T
L
T
L
G
T
EW
NQQ
R
MK
D
LSSNTQA
L
TGTNTG
G
AI
D
G
VSATDRSPYSKA
E
IF
SL
---
-
--
FAE
NNME
LTD
S
T
I
V
T
P
G
L
R
F
--------
DH
------------
HSIV
GN
----------
N
WSP
ALN
I
SQG
L
G
D
D
F
T
LK
M
G
IA
R
A
YKAP
S
L
Y
Q
TNPNYI
L
YSKGQ
G
CYA
--
SA
G
GCY
L
-----
Q
GN
D
DLK
A
E
T
S
I
N
K
EIG
LEF-KRD
G
W
L
A
G
I
T
W
F
R
N
D
YR
NKI
E
A
GYVAVGQ
N
A
VGTDLYQ
W
D
N
V
P
KA
V
VE
G
L
E
G
S
LNV
P
-
VSE
T
VMWTN
N
I
T
Y
M
-------
LK
SE
N
KT
---
T
G
D
----
RLS
I
IPEY
T
L
N
S
T
L
S
W
QAR
E
DLSMQTTF
T
WY
GK
QQ
P
KKY
-
NY
KGQP
AV
-----
G
PE
T
KEISP
Y
S
I
VGL
SAT
W
D
V
T
K
---
N
V
S
L
TGG
VDNLFDK
-
-
---R
L
WRA
G
N
AQT
TGDL
AG
ANYIA
G
A
G
A
---
Y
T
Y
NE
PGR
TW
Y
MSVN
TH
F
fig|478006.5.peg.825
Escherichia coli O157:H7 str. EC4501 (47-746/746)
A
P
G
VS
T
I
TA
D
EIR
K
N
-
PVAR
D
V
SE
I
I
R
T
-
M
PGV
N
L
TGN
S
TS
G
QR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
K
P
VSSRNS
VRQG
WR
G
E
R
D
TR
G
----
D
T
SWV
PP
-
EM
IERIEVLRGP
A
A
A
R
YGN
G
A
A
GGVVNIITKKG
S
--------------
GE
W
HG
S
WD
A
YF
N
AP
E
HK
E
E
---
G
----
AT
K
RT
NF
SLT
GPL
-
G
D
EFSF
R
LY
G
NLD
K
TQ
A
D
A
WDINQ
--
GHQSARAGTYA
T
T
L
PAGR
E
GVI
N
K
D
I
N
G
VV
--
R
W
D
F
A
P
L
Q
S
L
EL
E
AGY
SRQ
GNLYA
GDT
Q
NT
N
S
D
A
Y
TR
S
-
-KY
-----------------
G
D
E
T
N
R
L
YR
QNYSLTWNGGWDN
G
V
TTSNWVQ
Y
EH
T
R
---------
N
---------
-
S
R
---
IPE
GL
A
G
GTE
GKFNEKA
T
QDFV
DNDL
D
DVMLH
SE
V
NL
PI
DFLVNQ
T
L
T
L
G
T
EW
NQQ
R
MK
D
LSSNTQA
L
TGTNTG
G
AI
D
G
VSATDRSPYSKA
E
IF
SL
---
-
--
FAE
NNME
LTD
S
T
I
V
T
P
G
L
R
F
--------
DH
------------
HSIV
GN
----------
N
WSP
ALN
I
SQG
L
G
D
D
F
T
LK
M
G
IA
R
A
YKAP
S
L
Y
Q
TNPNYI
L
YSKGQ
G
CYA
--
SA
G
GCY
L
-----
Q
GN
D
DLK
A
E
T
S
I
N
K
EIG
LEF-KRD
G
W
L
A
G
I
T
W
F
R
N
D
YR
NKI
E
A
GYVAVGQ
N
A
VGTDLYQ
W
D
N
V
P
KA
V
VE
G
L
E
G
S
LNV
P
-
VSE
T
VMWTN
N
I
T
Y
M
-------
LK
SE
N
KT
---
T
G
D
----
RLS
I
IPEY
T
L
N
S
T
L
S
W
QAR
E
DLSMQTTF
T
WY
GK
QQ
P
KKY
-
NY
KGQP
AV
-----
G
PE
T
KEISP
Y
S
I
VGL
SAT
W
D
V
T
K
---
N
V
S
L
TGG
VDNLFDK
-
-
---R
L
WRA
G
N
AQT
TGDL
AG
ANYIA
G
A
G
A
---
Y
T
Y
NE
PGR
TW
Y
MSVN
TH
F
fig|478007.5.peg.977
Escherichia coli O157:H7 str. EC508 (47-746/746)
A
P
G
VS
T
I
TA
D
EIR
K
N
-
PVAR
D
V
SE
I
I
R
T
-
M
PGV
N
L
TGN
S
TS
G
QR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
K
P
VSSRNS
VRQG
WR
G
E
R
D
TR
G
----
D
T
SWV
PP
-
EM
IERIEVLRGP
A
A
A
R
YGN
G
A
A
GGVVNIITKKG
S
--------------
GE
W
HG
S
WD
A
YF
N
AP
E
HK
E
E
---
G
----
AT
K
RT
NF
SLT
GPL
-
G
D
EFSF
R
LY
G
NLD
K
TQ
A
D
A
WDINQ
--
GHQSARAGTYA
T
T
L
PAGR
E
GVI
N
K
D
I
N
G
VV
--
R
W
D
F
A
P
L
Q
S
L
EL
E
AGY
SRQ
GNLYA
GDT
Q
NT
N
S
D
A
Y
TR
S
-
-KY
-----------------
G
D
E
T
N
R
L
YR
QNYSLTWNGGWDN
G
V
TTSNWVQ
Y
EH
T
R
---------
N
---------
-
S
R
---
IPE
GL
A
G
GTE
GKFNEKA
T
QDFV
DNDL
D
DVMLH
SE
V
NL
PI
DFLVNQ
T
L
T
L
G
T
EW
NQQ
R
MK
D
LSSNTQA
L
TGTNTG
G
AI
D
G
VSATDRSPYSKA
E
IF
SL
---
-
--
FAE
NNME
LTD
S
T
I
V
T
P
G
L
R
F
--------
DH
------------
HSIV
GN
----------
N
WSP
ALN
I
SQG
L
G
D
D
F
T
LK
M
G
IA
R
A
YKAP
S
L
Y
Q
TNPNYI
L
YSKGQ
G
CYA
--
SA
G
GCY
L
-----
Q
GN
D
DLK
A
E
T
S
I
N
K
EIG
LEF-KRD
G
W
L
A
G
I
T
W
F
R
N
D
YR
NKI
E
A
GYVAVGQ
N
A
VGTDLYQ
W
D
N
V
P
KA
V
VE
G
L
E
G
S
LNV
P
-
VSE
T
VMWTN
N
I
T
Y
M
-------
LK
SE
N
KT
---
T
G
D
----
RLS
I
IPEY
T
L
N
S
T
L
S
W
QAR
E
DLSMQTTF
T
WY
GK
QQ
P
KKY
-
NY
KGQP
AV
-----
G
PE
T
KEISP
Y
S
I
VGL
SAT
W
D
V
T
K
---
N
V
S
L
TGG
VDNLFDK
-
-
---R
L
WRA
G
N
AQT
TGDL
AG
ANYIA
G
A
G
A
---
Y
T
Y
NE
PGR
TW
Y
MSVN
TH
F
fig|478008.5.peg.1720
Escherichia coli O157:H7 str. EC869 (47-746/746)
A
P
G
VS
T
I
TA
D
EIR
K
N
-
PVAR
D
V
SE
I
I
R
T
-
M
PGV
N
L
TGN
S
TS
G
QR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
K
P
VSSRNS
VRQG
WR
G
E
R
D
TR
G
----
D
T
SWV
PP
-
EM
IERIEVLRGP
A
A
A
R
YGN
G
A
A
GGVVNIITKKG
S
--------------
GE
W
HG
S
WD
A
YF
N
AP
E
HK
E
E
---
G
----
AT
K
RT
NF
SLT
GPL
-
G
D
EFSF
R
LY
G
NLD
K
TQ
A
D
A
WDINQ
--
GHQSARAGTYA
T
T
L
PAGR
E
GVI
N
K
D
I
N
G
VV
--
R
W
D
F
A
P
L
Q
S
L
EL
E
AGY
SRQ
GNLYA
GDT
Q
NT
N
S
D
A
Y
TR
S
-
-KY
-----------------
G
D
E
T
N
R
L
YR
QNYSLTWNGGWDN
G
V
TTSNWVQ
Y
EH
T
R
---------
N
---------
-
S
R
---
IPE
GL
A
G
GTE
GKFNEKA
T
QDFV
DNDL
D
DVMLH
SE
V
NL
PI
DFLVNQ
T
L
T
L
G
T
EW
NQQ
R
MK
D
LSSNTQA
L
TGTNTG
G
AI
D
G
VSATDRSPYSKA
E
IF
SL
---
-
--
FAE
NNME
LTD
S
T
I
V
T
P
G
L
R
F
--------
DH
------------
HSIV
GN
----------
N
WSP
ALN
I
SQG
L
G
D
D
F
T
LK
M
G
IA
R
A
YKAP
S
L
Y
Q
TNPNYI
L
YSKGQ
G
CYA
--
SA
G
GCY
L
-----
Q
GN
D
DLK
A
E
T
S
I
N
K
EIG
LEF-KRD
G
W
L
A
G
I
T
W
F
R
N
D
YR
NKI
E
A
GYVAVGQ
N
A
VGTDLYQ
W
D
N
V
P
KA
V
VE
G
L
E
G
S
LNV
P
-
VSE
T
VMWTN
N
I
T
Y
M
-------
LK
SE
N
KT
---
T
G
D
----
RLS
I
IPEY
T
L
N
S
T
L
S
W
QAR
E
DLSMQTTF
T
WY
GK
QQ
P
KKY
-
NY
KGQP
AV
-----
G
PE
T
KEISP
Y
S
I
VGL
SAT
W
D
V
T
K
---
N
V
S
L
TGG
VDNLFDK
-
-
---R
L
WRA
G
N
AQT
TGDL
AG
ANYIA
G
A
G
A
---
Y
T
Y
NE
PGR
TW
Y
MSVN
TH
F
fig|637388.3.peg.1115
Escherichia coli O157:H7 str. FRIK2000 (47-746/746)
A
P
G
VS
T
I
TA
D
EIR
K
N
-
PVAR
D
V
SE
I
I
R
T
-
M
PGV
N
L
TGN
S
TS
G
QR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
K
P
VSSRNS
VRQG
WR
G
E
R
D
TR
G
----
D
T
SWV
PP
-
EM
IERIEVLRGP
A
A
A
R
YGN
G
A
A
GGVVNIITKKG
S
--------------
GE
W
HG
S
WD
A
YF
N
AP
E
HK
E
E
---
G
----
AT
K
RT
NF
SLT
GPL
-
G
D
EFSF
R
LY
G
NLD
K
TQ
A
D
A
WDINQ
--
GHQSARAGTYA
T
T
L
PAGR
E
GVI
N
K
D
I
N
G
VV
--
R
W
D
F
A
P
L
Q
S
L
EL
E
AGY
SRQ
GNLYA
GDT
Q
NT
N
S
D
A
Y
TR
S
-
-KY
-----------------
G
D
E
T
N
R
L
YR
QNYSLTWNGGWDN
G
V
TTSNWVQ
Y
EH
T
R
---------
N
---------
-
S
R
---
IPE
GL
A
G
GTE
GKFNEKA
T
QDFV
DNDL
D
DVMLH
SE
V
NL
PI
DFLVNQ
T
L
T
L
G
T
EW
NQQ
R
MK
D
LSSNTQA
L
TGTNTG
G
AI
D
G
VSATDRSPYSKA
E
IF
SL
---
-
--
FAE
NNME
LTD
S
T
I
V
T
P
G
L
R
F
--------
DH
------------
HSIV
GN
----------
N
WSP
ALN
I
SQG
L
G
D
D
F
T
LK
M
G
IA
R
A
YKAP
S
L
Y
Q
TNPNYI
L
YSKGQ
G
CYA
--
SA
G
GCY
L
-----
Q
GN
D
DLK
A
E
T
S
I
N
K
EIG
LEF-KRD
G
W
L
A
G
I
T
W
F
R
N
D
YR
NKI
E
A
GYVAVGQ
N
A
VGTDLYQ
W
D
N
V
P
KA
V
VE
G
L
E
G
S
LNV
P
-
VSE
T
VMWTN
N
I
T
Y
M
-------
LK
SE
N
KT
---
T
G
D
----
RLS
I
IPEY
T
L
N
S
T
L
S
W
QAR
E
DLSMQTTF
T
WY
GK
QQ
P
KKY
-
NY
KGQP
AV
-----
G
PE
T
KEISP
Y
S
I
VGL
SAT
W
D
V
T
K
---
N
V
S
L
TGG
VDNLFDK
-
-
---R
L
WRA
G
N
AQT
TGDL
AG
ANYIA
G
A
G
A
---
Y
T
Y
NE
PGR
TW
Y
MSVN
TH
F
fig|570506.3.peg.3652
Escherichia coli O157:H7 str. FRIK966 (47-746/746)
A
P
G
VS
T
I
TA
D
EIR
K
N
-
PVAR
D
V
SE
I
I
R
T
-
M
PGV
N
L
TGN
S
TS
G
QR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
K
P
VSSRNS
VRQG
WR
G
E
R
D
TR
G
----
D
T
SWV
PP
-
EM
IERIEVLRGP
A
A
A
R
YGN
G
A
A
GGVVNIITKKG
S
--------------
GE
W
HG
S
WD
A
YF
N
AP
E
HK
E
E
---
G
----
AT
K
RT
NF
SLT
GPL
-
G
D
EFSF
R
LY
G
NLD
K
TQ
A
D
A
WDINQ
--
GHQSARAGTYA
T
T
L
PAGR
E
GVI
N
K
D
I
N
G
VV
--
R
W
D
F
A
P
L
Q
S
L
EL
E
AGY
SRQ
GNLYA
GDT
Q
NT
N
S
D
A
Y
TR
S
-
-KY
-----------------
G
D
E
T
N
R
L
YR
QNYSLTWNGGWDN
G
V
TTSNWVQ
Y
EH
T
R
---------
N
---------
-
S
R
---
IPE
GL
A
G
GTE
GKFNEKA
T
QDFV
DNDL
D
DVMLH
SE
V
NL
PI
DFLVNQ
T
L
T
L
G
T
EW
NQQ
R
MK
D
LSSNTQA
L
TGTNTG
G
AI
D
G
VSATDRSPYSKA
E
IF
SL
---
-
--
FAE
NNME
LTD
S
T
I
V
T
P
G
L
R
F
--------
DH
------------
HSIV
GN
----------
N
WSP
ALN
I
SQG
L
G
D
D
F
T
LK
M
G
IA
R
A
YKAP
S
L
Y
Q
TNPNYI
L
YSKGQ
G
CYA
--
SA
G
GCY
L
-----
Q
GN
D
DLK
A
E
T
S
I
N
K
EIG
LEF-KRD
G
W
L
A
G
I
T
W
F
R
N
D
YR
NKI
E
A
GYVAVGQ
N
A
VGTDLYQ
W
D
N
V
P
KA
V
VE
G
L
E
G
S
LNV
P
-
VSE
T
VMWTN
N
I
T
Y
M
-------
LK
SE
N
KT
---
T
G
D
----
RLS
I
IPEY
T
L
N
S
T
L
S
W
QAR
E
DLSMQTTF
T
WY
GK
QQ
P
KKY
-
NY
KGQP
AV
-----
G
PE
T
KEISP
Y
S
I
VGL
SAT
W
D
V
T
K
---
N
V
S
L
TGG
VDNLFDK
-
-
---R
L
WRA
G
N
AQT
TGDL
AG
ANYIA
G
A
G
A
---
Y
T
Y
NE
PGR
TW
Y
MSVN
TH
F
fig|386585.9.peg.731
Escherichia coli O157:H7 str. Sakai (47-746/746)
A
P
G
VS
T
I
TA
D
EIR
K
N
-
PVAR
D
V
SE
I
I
R
T
-
M
PGV
N
L
TGN
S
TS
G
QR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
K
P
VSSRNS
VRQG
WR
G
E
R
D
TR
G
----
D
T
SWV
PP
-
EM
IERIEVLRGP
A
A
A
R
YGN
G
A
A
GGVVNIITKKG
S
--------------
GE
W
HG
S
WD
A
YF
N
AP
E
HK
E
E
---
G
----
AT
K
RT
NF
SLT
GPL
-
G
D
EFSF
R
LY
G
NLD
K
TQ
A
D
A
WDINQ
--
GHQSARAGTYA
T
T
L
PAGR
E
GVI
N
K
D
I
N
G
VV
--
R
W
D
F
A
P
L
Q
S
L
EL
E
AGY
SRQ
GNLYA
GDT
Q
NT
N
S
D
A
Y
TR
S
-
-KY
-----------------
G
D
E
T
N
R
L
YR
QNYSLTWNGGWDN
G
V
TTSNWVQ
Y
EH
T
R
---------
N
---------
-
S
R
---
IPE
GL
A
G
GTE
GKFNEKA
T
QDFV
DNDL
D
DVMLH
SE
V
NL
PI
DFLVNQ
T
L
T
L
G
T
EW
NQQ
R
MK
D
LSSNTQA
L
TGTNTG
G
AI
D
G
VSATDRSPYSKA
E
IF
SL
---
-
--
FAE
NNME
LTD
S
T
I
V
T
P
G
L
R
F
--------
DH
------------
HSIV
GN
----------
N
WSP
ALN
I
SQG
L
G
D
D
F
T
LK
M
G
IA
R
A
YKAP
S
L
Y
Q
TNPNYI
L
YSKGQ
G
CYA
--
SA
G
GCY
L
-----
Q
GN
D
DLK
A
E
T
S
I
N
K
EIG
LEF-KRD
G
W
L
A
G
I
T
W
F
R
N
D
YR
NKI
E
A
GYVAVGQ
N
A
VGTDLYQ
W
D
N
V
P
KA
V
VE
G
L
E
G
S
LNV
P
-
VSE
T
VMWTN
N
I
T
Y
M
-------
LK
SE
N
KT
---
T
G
D
----
RLS
I
IPEY
T
L
N
S
T
L
S
W
QAR
E
DLSMQTTF
T
WY
GK
QQ
P
KKY
-
NY
KGQP
AV
-----
G
PE
T
KEISP
Y
S
I
VGL
SAT
W
D
V
T
K
---
N
V
S
L
TGG
VDNLFDK
-
-
---R
L
WRA
G
N
AQT
TGDL
AG
ANYIA
G
A
G
A
---
Y
T
Y
NE
PGR
TW
Y
MSVN
TH
F
fig|544404.4.peg.643
Escherichia coli O157:H7 str. TW14359 (47-746/746)
A
P
G
VS
T
I
TA
D
EIR
K
N
-
PVAR
D
V
SE
I
I
R
T
-
M
PGV
N
L
TGN
S
TS
G
QR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
K
P
VSSRNS
VRQG
WR
G
E
R
D
TR
G
----
D
T
SWV
PP
-
EM
IERIEVLRGP
A
A
A
R
YGN
G
A
A
GGVVNIITKKG
S
--------------
GE
W
HG
S
WD
A
YF
N
AP
E
HK
E
E
---
G
----
AT
K
RT
NF
SLT
GPL
-
G
D
EFSF
R
LY
G
NLD
K
TQ
A
D
A
WDINQ
--
GHQSARAGTYA
T
T
L
PAGR
E
GVI
N
K
D
I
N
G
VV
--
R
W
D
F
A
P
L
Q
S
L
EL
E
AGY
SRQ
GNLYA
GDT
Q
NT
N
S
D
A
Y
TR
S
-
-KY
-----------------
G
D
E
T
N
R
L
YR
QNYSLTWNGGWDN
G
V
TTSNWVQ
Y
EH
T
R
---------
N
---------
-
S
R
---
IPE
GL
A
G
GTE
GKFNEKA
T
QDFV
DNDL
D
DVMLH
SE
V
NL
PI
DFLVNQ
T
L
T
L
G
T
EW
NQQ
R
MK
D
LSSNTQA
L
TGTNTG
G
AI
D
G
VSATDRSPYSKA
E
IF
SL
---
-
--
FAE
NNME
LTD
S
T
I
V
T
P
G
L
R
F
--------
DH
------------
HSIV
GN
----------
N
WSP
ALN
I
SQG
L
G
D
D
F
T
LK
M
G
IA
R
A
YKAP
S
L
Y
Q
TNPNYI
L
YSKGQ
G
CYA
--
SA
G
GCY
L
-----
Q
GN
D
DLK
A
E
T
S
I
N
K
EIG
LEF-KRD
G
W
L
A
G
I
T
W
F
R
N
D
YR
NKI
E
A
GYVAVGQ
N
A
VGTDLYQ
W
D
N
V
P
KA
V
VE
G
L
E
G
S
LNV
P
-
VSE
T
VMWTN
N
I
T
Y
M
-------
LK
SE
N
KT
---
T
G
D
----
RLS
I
IPEY
T
L
N
S
T
L
S
W
QAR
E
DLSMQTTF
T
WY
GK
QQ
P
KKY
-
NY
KGQP
AV
-----
G
PE
T
KEISP
Y
S
I
VGL
SAT
W
D
V
T
K
---
N
V
S
L
TGG
VDNLFDK
-
-
---R
L
WRA
G
N
AQT
TGDL
AG
ANYIA
G
A
G
A
---
Y
T
Y
NE
PGR
TW
Y
MSVN
TH
F
fig|502346.5.peg.578
Escherichia coli O157:H7 str. TW14588 (47-746/746)
A
P
G
VS
T
I
TA
D
EIR
K
N
-
PVAR
D
V
SE
I
I
R
T
-
M
PGV
N
L
TGN
S
TS
G
QR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
K
P
VSSRNS
VRQG
WR
G
E
R
D
TR
G
----
D
T
SWV
PP
-
EM
IERIEVLRGP
A
A
A
R
YGN
G
A
A
GGVVNIITKKG
S
--------------
GE
W
HG
S
WD
A
YF
N
AP
E
HK
E
E
---
G
----
AT
K
RT
NF
SLT
GPL
-
G
D
EFSF
R
LY
G
NLD
K
TQ
A
D
A
WDINQ
--
GHQSARAGTYA
T
T
L
PAGR
E
GVI
N
K
D
I
N
G
VV
--
R
W
D
F
A
P
L
Q
S
L
EL
E
AGY
SRQ
GNLYA
GDT
Q
NT
N
S
D
A
Y
TR
S
-
-KY
-----------------
G
D
E
T
N
R
L
YR
QNYSLTWNGGWDN
G
V
TTSNWVQ
Y
EH
T
R
---------
N
---------
-
S
R
---
IPE
GL
A
G
GTE
GKFNEKA
T
QDFV
DNDL
D
DVMLH
SE
V
NL
PI
DFLVNQ
T
L
T
L
G
T
EW
NQQ
R
MK
D
LSSNTQA
L
TGTNTG
G
AI
D
G
VSATDRSPYSKA
E
IF
SL
---
-
--
FAE
NNME
LTD
S
T
I
V
T
P
G
L
R
F
--------
DH
------------
HSIV
GN
----------
N
WSP
ALN
I
SQG
L
G
D
D
F
T
LK
M
G
IA
R
A
YKAP
S
L
Y
Q
TNPNYI
L
YSKGQ
G
CYA
--
SA
G
GCY
L
-----
Q
GN
D
DLK
A
E
T
S
I
N
K
EIG
LEF-KRD
G
W
L
A
G
I
T
W
F
R
N
D
YR
NKI
E
A
GYVAVGQ
N
A
VGTDLYQ
W
D
N
V
P
KA
V
VE
G
L
E
G
S
LNV
P
-
VSE
T
VMWTN
N
I
T
Y
M
-------
LK
SE
N
KT
---
T
G
D
----
RLS
I
IPEY
T
L
N
S
T
L
S
W
QAR
E
DLSMQTTF
T
WY
GK
QQ
P
KKY
-
NY
KGQP
AV
-----
G
PE
T
KEISP
Y
S
I
VGL
SAT
W
D
V
T
K
---
N
V
S
L
TGG
VDNLFDK
-
-
---R
L
WRA
G
N
AQT
TGDL
AG
ANYIA
G
A
G
A
---
Y
T
Y
NE
PGR
TW
Y
MSVN
TH
F
fig|701177.3.peg.743
Escherichia coli O55:H7 str. CB9615 (47-746/746)
A
P
G
VS
T
I
TA
D
EIR
K
N
-
PVAR
D
V
SE
I
I
R
T
-
M
PGV
N
L
TGN
S
TS
G
QR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
K
P
VSSRNS
VRQG
WR
G
E
R
D
TR
G
----
D
T
SWV
PP
-
EM
IERIEVLRGP
A
A
A
R
YGN
G
A
A
GGVVNIITKKG
S
--------------
GE
W
HG
S
WD
A
YF
N
AP
E
HK
E
E
---
G
----
AT
K
RT
NF
SLT
GPL
-
G
D
EFSF
R
LY
G
NLD
K
TQ
A
D
A
WDINQ
--
GHQSARAGTYA
T
T
L
PAGR
E
GVI
N
K
D
I
N
G
VV
--
R
W
D
F
A
P
L
Q
S
L
EL
E
AGY
SRQ
GNLYA
GDT
Q
NT
N
S
D
A
Y
TR
S
-
-KY
-----------------
G
D
E
T
N
R
L
YR
QNYSLTWNGGWDN
G
V
TTSNWVQ
Y
EH
T
R
---------
N
---------
-
S
R
---
IPE
GL
A
G
GTE
GKFNEKA
T
QDFV
DNDL
D
DVMLH
SE
V
NL
PI
DFLVNQ
T
L
T
L
G
T
EW
NQQ
R
MK
D
LSSNTQA
L
TGTNTG
G
AI
D
G
VSATDRSPYSKA
E
IF
SL
---
-
--
FAE
NNME
LTD
S
T
I
V
T
P
G
L
R
F
--------
DH
------------
HSIV
GN
----------
N
WSP
ALN
I
SQG
L
G
D
D
F
T
LK
M
G
IA
R
A
YKAP
S
L
Y
Q
TNPNYI
L
YSKGQ
G
CYA
--
SA
G
GCY
L
-----
Q
GN
D
DLK
A
E
T
S
I
N
K
EIG
LEF-KRD
G
W
L
A
G
I
T
W
F
R
N
D
YR
NKI
E
A
GYVAVGQ
N
A
VGTDLYQ
W
D
N
V
P
KA
V
VE
G
L
E
G
S
LNV
P
-
VSE
T
VMWTN
N
I
T
Y
M
-------
LK
SE
N
KT
---
T
G
D
----
RLS
I
IPEY
T
L
N
S
T
L
S
W
QAR
E
DLSMQTTF
T
WY
GK
QQ
P
KKY
-
NY
KGQP
AV
-----
G
PE
T
KEISP
Y
S
I
VGL
SAT
W
D
V
T
K
---
N
V
S
L
TGG
VDNLFDK
-
-
---R
L
WRA
G
N
AQT
TGDL
AG
ANYIA
G
A
G
A
---
Y
T
Y
NE
PGR
TW
Y
MSVN
TH
F
fig|749547.3.peg.3575
Escherichia coli MS 187-1 (47-746/746)
A
P
G
VS
T
I
TA
D
EIR
K
N
-
PVAR
D
V
SE
I
I
R
T
-
M
PGV
N
L
TGN
S
TS
G
QR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
K
P
VSSRNS
VRQG
WR
G
E
R
D
TR
G
----
D
T
SWV
PP
-
EM
IERIEVLRGP
A
A
A
R
YGN
G
A
A
GGVVNIITKKG
S
--------------
GE
W
HG
S
WG
A
YF
N
AP
E
HK
E
E
---
G
----
AT
K
RT
NF
SLT
GPL
-
G
D
EFSF
R
LY
G
NLD
K
TQ
A
D
A
WDINQ
--
GHQSARAGTYA
T
T
L
PAGR
E
GVI
N
K
D
I
N
G
VV
--
R
W
D
F
A
P
L
Q
S
L
EL
E
AGY
SRQ
GNLYA
GDT
Q
NT
N
S
D
S
Y
TR
S
-
-KY
-----------------
G
D
E
T
N
R
L
YR
QNYALTWNGGWDN
G
V
TTSNWVQ
Y
EH
T
R
---------
N
---------
-
S
R
---
IPE
GL
A
G
GTE
GKFNEKA
T
QDFV
DIDL
D
DVMLH
SE
V
NL
PI
DFLVNQ
T
L
T
L
G
T
EW
NQQ
R
MK
D
LSSNTQA
L
TGTNTG
G
AI
D
G
VSTTDRSPYSKA
E
IF
SL
---
-
--
FAE
NNME
LTD
S
T
I
V
T
P
G
L
R
F
--------
DH
------------
HSIV
GN
----------
N
WSP
ALN
I
SQG
L
G
D
D
F
T
LK
M
G
IA
R
A
YKAP
S
L
Y
Q
TNPNYI
L
YSKGQ
G
CYA
--
SA
G
GCY
L
-----
Q
GN
D
DLK
A
E
T
S
I
N
K
EIG
LEF-KRD
G
W
L
A
G
VT
W
F
R
N
D
YR
NKI
E
A
GYVAVGQ
N
A
VGTDLYQ
W
D
N
V
P
KA
V
VE
G
L
E
G
S
LNV
P
-
VSE
T
VMWTN
N
I
T
Y
M
-------
LK
SE
N
KT
---
T
G
D
----
RLS
I
IPEY
T
L
N
S
T
L
S
W
QAR
E
DLSMQTTF
T
WY
GK
QQ
P
KKY
-
NY
KGQP
AV
-----
G
PE
T
KEISP
Y
S
I
VGL
SAT
W
D
V
T
K
---
N
V
S
L
TGG
VDNLFDK
-
-
---R
L
WRA
G
N
AQT
TGDL
AG
ANYIA
G
A
G
A
---
Y
T
Y
NE
PGR
TW
Y
MSVN
TH
F
fig|595496.3.peg.506
Escherichia coli BW2952 (47-746/746)
A
P
G
VS
T
I
TA
D
EIR
K
N
-
PVAR
D
V
S
K
I
I
R
T
-
M
PGV
N
L
TGN
S
TS
G
QR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
K
P
VSSRNS
VRQG
WR
G
E
R
D
TR
G
----
D
T
SWV
PP
-
EM
IERIEVLRGP
A
A
A
R
YGN
G
A
A
GGVVNIITKKG
S
--------------
GE
W
HG
S
WD
A
YF
N
AP
E
HK
E
E
---
G
----
AT
K
RT
NF
SLT
GPL
-
G
D
EFSF
R
LY
G
NLD
K
TQ
A
D
A
WDINQ
--
GHQSARAGTYA
T
T
L
PAGR
E
GVI
N
K
D
I
N
G
VV
--
R
W
D
F
A
P
L
Q
S
L
EL
E
AGY
SRQ
GNLYA
GDT
Q
NT
N
S
D
S
Y
TR
S
-
-KY
-----------------
G
D
E
T
N
R
L
YR
QNYALTWNGGWDN
G
V
TTSNWVQ
Y
EH
T
R
---------
N
---------
-
S
R
---
IPE
GL
A
G
GTE
GKFNEKA
T
QDFV
DIDL
D
DVMLH
SE
V
NL
PI
DFLVNQ
T
L
T
L
G
T
EW
NQQ
R
MK
D
LSSNTQA
L
TGTNTG
G
AI
D
G
VSTTDRSPYSKA
E
IF
SL
---
-
--
FAE
NNME
LTD
S
T
I
V
T
P
G
L
R
F
--------
DH
------------
HSIV
GN
----------
N
WSP
ALN
I
SQG
L
G
D
D
F
T
LK
M
G
IA
R
A
YKAP
S
L
Y
Q
TNPNYI
L
YSKGQ
G
CYA
--
SA
G
GCY
L
-----
Q
GN
D
DLK
A
E
T
S
I
N
K
EIG
LEF-KRD
G
W
L
A
G
VT
W
F
R
N
D
YR
NKI
E
A
GYVAVGQ
N
A
VGTDLYQ
W
D
N
V
P
KA
V
VE
G
L
E
G
S
LNV
P
-
VSE
T
VMWTN
N
I
T
Y
M
-------
LK
SE
N
KT
---
T
G
D
----
RLS
I
IPEY
T
L
N
S
T
L
S
W
QAR
E
DLSMQTTF
T
WY
GK
QQ
P
KKY
-
NY
KGQP
AV
-----
G
PE
T
KEISP
Y
S
I
VGL
SAT
W
D
V
T
K
---
N
V
S
L
TGG
VDNLFDK
-
-
---R
L
WRA
G
N
AQT
TGDL
AG
ANYIA
G
A
G
A
---
Y
T
Y
NE
PGR
TW
Y
MSVN
TH
F
fig|536056.3.peg.3217
Escherichia coli DH1 (47-746/746)
A
P
G
VS
T
I
TA
D
EIR
K
N
-
PVAR
D
V
S
K
I
I
R
T
-
M
PGV
N
L
TGN
S
TS
G
QR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
K
P
VSSRNS
VRQG
WR
G
E
R
D
TR
G
----
D
T
SWV
PP
-
EM
IERIEVLRGP
A
A
A
R
YGN
G
A
A
GGVVNIITKKG
S
--------------
GE
W
HG
S
WD
A
YF
N
AP
E
HK
E
E
---
G
----
AT
K
RT
NF
SLT
GPL
-
G
D
EFSF
R
LY
G
NLD
K
TQ
A
D
A
WDINQ
--
GHQSARAGTYA
T
T
L
PAGR
E
GVI
N
K
D
I
N
G
VV
--
R
W
D
F
A
P
L
Q
S
L
EL
E
AGY
SRQ
GNLYA
GDT
Q
NT
N
S
D
S
Y
TR
S
-
-KY
-----------------
G
D
E
T
N
R
L
YR
QNYALTWNGGWDN
G
V
TTSNWVQ
Y
EH
T
R
---------
N
---------
-
S
R
---
IPE
GL
A
G
GTE
GKFNEKA
T
QDFV
DIDL
D
DVMLH
SE
V
NL
PI
DFLVNQ
T
L
T
L
G
T
EW
NQQ
R
MK
D
LSSNTQA
L
TGTNTG
G
AI
D
G
VSTTDRSPYSKA
E
IF
SL
---
-
--
FAE
NNME
LTD
S
T
I
V
T
P
G
L
R
F
--------
DH
------------
HSIV
GN
----------
N
WSP
ALN
I
SQG
L
G
D
D
F
T
LK
M
G
IA
R
A
YKAP
S
L
Y
Q
TNPNYI
L
YSKGQ
G
CYA
--
SA
G
GCY
L
-----
Q
GN
D
DLK
A
E
T
S
I
N
K
EIG
LEF-KRD
G
W
L
A
G
VT
W
F
R
N
D
YR
NKI
E
A
GYVAVGQ
N
A
VGTDLYQ
W
D
N
V
P
KA
V
VE
G
L
E
G
S
LNV
P
-
VSE
T
VMWTN
N
I
T
Y
M
-------
LK
SE
N
KT
---
T
G
D
----
RLS
I
IPEY
T
L
N
S
T
L
S
W
QAR
E
DLSMQTTF
T
WY
GK
QQ
P
KKY
-
NY
KGQP
AV
-----
G
PE
T
KEISP
Y
S
I
VGL
SAT
W
D
V
T
K
---
N
V
S
L
TGG
VDNLFDK
-
-
---R
L
WRA
G
N
AQT
TGDL
AG
ANYIA
G
A
G
A
---
Y
T
Y
NE
PGR
TW
Y
MSVN
TH
F
fig|83333.1.peg.583
Escherichia coli K12 (47-746/746)
A
P
G
VS
T
I
TA
D
EIR
K
N
-
PVAR
D
V
S
K
I
I
R
T
-
M
PGV
N
L
TGN
S
TS
G
QR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
K
P
VSSRNS
VRQG
WR
G
E
R
D
TR
G
----
D
T
SWV
PP
-
EM
IERIEVLRGP
A
A
A
R
YGN
G
A
A
GGVVNIITKKG
S
--------------
GE
W
HG
S
WD
A
YF
N
AP
E
HK
E
E
---
G
----
AT
K
RT
NF
SLT
GPL
-
G
D
EFSF
R
LY
G
NLD
K
TQ
A
D
A
WDINQ
--
GHQSARAGTYA
T
T
L
PAGR
E
GVI
N
K
D
I
N
G
VV
--
R
W
D
F
A
P
L
Q
S
L
EL
E
AGY
SRQ
GNLYA
GDT
Q
NT
N
S
D
S
Y
TR
S
-
-KY
-----------------
G
D
E
T
N
R
L
YR
QNYALTWNGGWDN
G
V
TTSNWVQ
Y
EH
T
R
---------
N
---------
-
S
R
---
IPE
GL
A
G
GTE
GKFNEKA
T
QDFV
DIDL
D
DVMLH
SE
V
NL
PI
DFLVNQ
T
L
T
L
G
T
EW
NQQ
R
MK
D
LSSNTQA
L
TGTNTG
G
AI
D
G
VSTTDRSPYSKA
E
IF
SL
---
-
--
FAE
NNME
LTD
S
T
I
V
T
P
G
L
R
F
--------
DH
------------
HSIV
GN
----------
N
WSP
ALN
I
SQG
L
G
D
D
F
T
LK
M
G
IA
R
A
YKAP
S
L
Y
Q
TNPNYI
L
YSKGQ
G
CYA
--
SA
G
GCY
L
-----
Q
GN
D
DLK
A
E
T
S
I
N
K
EIG
LEF-KRD
G
W
L
A
G
VT
W
F
R
N
D
YR
NKI
E
A
GYVAVGQ
N
A
VGTDLYQ
W
D
N
V
P
KA
V
VE
G
L
E
G
S
LNV
P
-
VSE
T
VMWTN
N
I
T
Y
M
-------
LK
SE
N
KT
---
T
G
D
----
RLS
I
IPEY
T
L
N
S
T
L
S
W
QAR
E
DLSMQTTF
T
WY
GK
QQ
P
KKY
-
NY
KGQP
AV
-----
G
PE
T
KEISP
Y
S
I
VGL
SAT
W
D
V
T
K
---
N
V
S
L
TGG
VDNLFDK
-
-
---R
L
WRA
G
N
AQT
TGDL
AG
ANYIA
G
A
G
A
---
Y
T
Y
NE
PGR
TW
Y
MSVN
TH
F
fig|316407.3.peg.566
Escherichia coli W3110 (47-746/746)
A
P
G
VS
T
I
TA
D
EIR
K
N
-
PVAR
D
V
S
K
I
I
R
T
-
M
PGV
N
L
TGN
S
TS
G
QR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
K
P
VSSRNS
VRQG
WR
G
E
R
D
TR
G
----
D
T
SWV
PP
-
EM
IERIEVLRGP
A
A
A
R
YGN
G
A
A
GGVVNIITKKG
S
--------------
GE
W
HG
S
WD
A
YF
N
AP
E
HK
E
E
---
G
----
AT
K
RT
NF
SLT
GPL
-
G
D
EFSF
R
LY
G
NLD
K
TQ
A
D
A
WDINQ
--
GHQSARAGTYA
T
T
L
PAGR
E
GVI
N
K
D
I
N
G
VV
--
R
W
D
F
A
P
L
Q
S
L
EL
E
AGY
SRQ
GNLYA
GDT
Q
NT
N
S
D
S
Y
TR
S
-
-KY
-----------------
G
D
E
T
N
R
L
YR
QNYALTWNGGWDN
G
V
TTSNWVQ
Y
EH
T
R
---------
N
---------
-
S
R
---
IPE
GL
A
G
GTE
GKFNEKA
T
QDFV
DIDL
D
DVMLH
SE
V
NL
PI
DFLVNQ
T
L
T
L
G
T
EW
NQQ
R
MK
D
LSSNTQA
L
TGTNTG
G
AI
D
G
VSTTDRSPYSKA
E
IF
SL
---
-
--
FAE
NNME
LTD
S
T
I
V
T
P
G
L
R
F
--------
DH
------------
HSIV
GN
----------
N
WSP
ALN
I
SQG
L
G
D
D
F
T
LK
M
G
IA
R
A
YKAP
S
L
Y
Q
TNPNYI
L
YSKGQ
G
CYA
--
SA
G
GCY
L
-----
Q
GN
D
DLK
A
E
T
S
I
N
K
EIG
LEF-KRD
G
W
L
A
G
VT
W
F
R
N
D
YR
NKI
E
A
GYVAVGQ
N
A
VGTDLYQ
W
D
N
V
P
KA
V
VE
G
L
E
G
S
LNV
P
-
VSE
T
VMWTN
N
I
T
Y
M
-------
LK
SE
N
KT
---
T
G
D
----
RLS
I
IPEY
T
L
N
S
T
L
S
W
QAR
E
DLSMQTTF
T
WY
GK
QQ
P
KKY
-
NY
KGQP
AV
-----
G
PE
T
KEISP
Y
S
I
VGL
SAT
W
D
V
T
K
---
N
V
S
L
TGG
VDNLFDK
-
-
---R
L
WRA
G
N
AQT
TGDL
AG
ANYIA
G
A
G
A
---
Y
T
Y
NE
PGR
TW
Y
MSVN
TH
F
fig|316385.5.peg.537
Escherichia coli str. K-12 substr. DH10B (47-746/746)
A
P
G
VS
T
I
TA
D
EIR
K
N
-
PVAR
D
V
S
K
I
I
R
T
-
M
PGV
N
L
TGN
S
TS
G
QR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
K
P
VSSRNS
VRQG
WR
G
E
R
D
TR
G
----
D
T
SWV
PP
-
EM
IERIEVLRGP
A
A
A
R
YGN
G
A
A
GGVVNIITKKG
S
--------------
GE
W
HG
S
WD
A
YF
N
AP
E
HK
E
E
---
G
----
AT
K
RT
NF
SLT
GPL
-
G
D
EFSF
R
LY
G
NLD
K
TQ
A
D
A
WDINQ
--
GHQSARAGTYA
T
T
L
PAGR
E
GVI
N
K
D
I
N
G
VV
--
R
W
D
F
A
P
L
Q
S
L
EL
E
AGY
SRQ
GNLYA
GDT
Q
NT
N
S
D
S
Y
TR
S
-
-KY
-----------------
G
D
E
T
N
R
L
YR
QNYALTWNGGWDN
G
V
TTSNWVQ
Y
EH
T
R
---------
N
---------
-
S
R
---
IPE
GL
A
G
GTE
GKFNEKA
T
QDFV
DIDL
D
DVMLH
SE
V
NL
PI
DFLVNQ
T
L
T
L
G
T
EW
NQQ
R
MK
D
LSSNTQA
L
TGTNTG
G
AI
D
G
VSTTDRSPYSKA
E
IF
SL
---
-
--
FAE
NNME
LTD
S
T
I
V
T
P
G
L
R
F
--------
DH
------------
HSIV
GN
----------
N
WSP
ALN
I
SQG
L
G
D
D
F
T
LK
M
G
IA
R
A
YKAP
S
L
Y
Q
TNPNYI
L
YSKGQ
G
CYA
--
SA
G
GCY
L
-----
Q
GN
D
DLK
A
E
T
S
I
N
K
EIG
LEF-KRD
G
W
L
A
G
VT
W
F
R
N
D
YR
NKI
E
A
GYVAVGQ
N
A
VGTDLYQ
W
D
N
V
P
KA
V
VE
G
L
E
G
S
LNV
P
-
VSE
T
VMWTN
N
I
T
Y
M
-------
LK
SE
N
KT
---
T
G
D
----
RLS
I
IPEY
T
L
N
S
T
L
S
W
QAR
E
DLSMQTTF
T
WY
GK
QQ
P
KKY
-
NY
KGQP
AV
-----
G
PE
T
KEISP
Y
S
I
VGL
SAT
W
D
V
T
K
---
N
V
S
L
TGG
VDNLFDK
-
-
---R
L
WRA
G
N
AQT
TGDL
AG
ANYIA
G
A
G
A
---
Y
T
Y
NE
PGR
TW
Y
MSVN
TH
F
fig|316385.5.peg.648
Escherichia coli str. K-12 substr. DH10B (47-746/746)
A
P
G
VS
T
I
TA
D
EIR
K
N
-
PVAR
D
V
S
K
I
I
R
T
-
M
PGV
N
L
TGN
S
TS
G
QR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
K
P
VSSRNS
VRQG
WR
G
E
R
D
TR
G
----
D
T
SWV
PP
-
EM
IERIEVLRGP
A
A
A
R
YGN
G
A
A
GGVVNIITKKG
S
--------------
GE
W
HG
S
WD
A
YF
N
AP
E
HK
E
E
---
G
----
AT
K
RT
NF
SLT
GPL
-
G
D
EFSF
R
LY
G
NLD
K
TQ
A
D
A
WDINQ
--
GHQSARAGTYA
T
T
L
PAGR
E
GVI
N
K
D
I
N
G
VV
--
R
W
D
F
A
P
L
Q
S
L
EL
E
AGY
SRQ
GNLYA
GDT
Q
NT
N
S
D
S
Y
TR
S
-
-KY
-----------------
G
D
E
T
N
R
L
YR
QNYALTWNGGWDN
G
V
TTSNWVQ
Y
EH
T
R
---------
N
---------
-
S
R
---
IPE
GL
A
G
GTE
GKFNEKA
T
QDFV
DIDL
D
DVMLH
SE
V
NL
PI
DFLVNQ
T
L
T
L
G
T
EW
NQQ
R
MK
D
LSSNTQA
L
TGTNTG
G
AI
D
G
VSTTDRSPYSKA
E
IF
SL
---
-
--
FAE
NNME
LTD
S
T
I
V
T
P
G
L
R
F
--------
DH
------------
HSIV
GN
----------
N
WSP
ALN
I
SQG
L
G
D
D
F
T
LK
M
G
IA
R
A
YKAP
S
L
Y
Q
TNPNYI
L
YSKGQ
G
CYA
--
SA
G
GCY
L
-----
Q
GN
D
DLK
A
E
T
S
I
N
K
EIG
LEF-KRD
G
W
L
A
G
VT
W
F
R
N
D
YR
NKI
E
A
GYVAVGQ
N
A
VGTDLYQ
W
D
N
V
P
KA
V
VE
G
L
E
G
S
LNV
P
-
VSE
T
VMWTN
N
I
T
Y
M
-------
LK
SE
N
KT
---
T
G
D
----
RLS
I
IPEY
T
L
N
S
T
L
S
W
QAR
E
DLSMQTTF
T
WY
GK
QQ
P
KKY
-
NY
KGQP
AV
-----
G
PE
T
KEISP
Y
S
I
VGL
SAT
W
D
V
T
K
---
N
V
S
L
TGG
VDNLFDK
-
-
---R
L
WRA
G
N
AQT
TGDL
AG
ANYIA
G
A
G
A
---
Y
T
Y
NE
PGR
TW
Y
MSVN
TH
F
fig|316385.7.peg.545
Escherichia coli str. K-12 substr. DH10B (47-746/746)
A
P
G
VS
T
I
TA
D
EIR
K
N
-
PVAR
D
V
S
K
I
I
R
T
-
M
PGV
N
L
TGN
S
TS
G
QR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
K
P
VSSRNS
VRQG
WR
G
E
R
D
TR
G
----
D
T
SWV
PP
-
EM
IERIEVLRGP
A
A
A
R
YGN
G
A
A
GGVVNIITKKG
S
--------------
GE
W
HG
S
WD
A
YF
N
AP
E
HK
E
E
---
G
----
AT
K
RT
NF
SLT
GPL
-
G
D
EFSF
R
LY
G
NLD
K
TQ
A
D
A
WDINQ
--
GHQSARAGTYA
T
T
L
PAGR
E
GVI
N
K
D
I
N
G
VV
--
R
W
D
F
A
P
L
Q
S
L
EL
E
AGY
SRQ
GNLYA
GDT
Q
NT
N
S
D
S
Y
TR
S
-
-KY
-----------------
G
D
E
T
N
R
L
YR
QNYALTWNGGWDN
G
V
TTSNWVQ
Y
EH
T
R
---------
N
---------
-
S
R
---
IPE
GL
A
G
GTE
GKFNEKA
T
QDFV
DIDL
D
DVMLH
SE
V
NL
PI
DFLVNQ
T
L
T
L
G
T
EW
NQQ
R
MK
D
LSSNTQA
L
TGTNTG
G
AI
D
G
VSTTDRSPYSKA
E
IF
SL
---
-
--
FAE
NNME
LTD
S
T
I
V
T
P
G
L
R
F
--------
DH
------------
HSIV
GN
----------
N
WSP
ALN
I
SQG
L
G
D
D
F
T
LK
M
G
IA
R
A
YKAP
S
L
Y
Q
TNPNYI
L
YSKGQ
G
CYA
--
SA
G
GCY
L
-----
Q
GN
D
DLK
A
E
T
S
I
N
K
EIG
LEF-KRD
G
W
L
A
G
VT
W
F
R
N
D
YR
NKI
E
A
GYVAVGQ
N
A
VGTDLYQ
W
D
N
V
P
KA
V
VE
G
L
E
G
S
LNV
P
-
VSE
T
VMWTN
N
I
T
Y
M
-------
LK
SE
N
KT
---
T
G
D
----
RLS
I
IPEY
T
L
N
S
T
L
S
W
QAR
E
DLSMQTTF
T
WY
GK
QQ
P
KKY
-
NY
KGQP
AV
-----
G
PE
T
KEISP
Y
S
I
VGL
SAT
W
D
V
T
K
---
N
V
S
L
TGG
VDNLFDK
-
-
---R
L
WRA
G
N
AQT
TGDL
AG
ANYIA
G
A
G
A
---
Y
T
Y
NE
PGR
TW
Y
MSVN
TH
F
fig|316385.7.peg.656
Escherichia coli str. K-12 substr. DH10B (47-746/746)
A
P
G
VS
T
I
TA
D
EIR
K
N
-
PVAR
D
V
S
K
I
I
R
T
-
M
PGV
N
L
TGN
S
TS
G
QR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
K
P
VSSRNS
VRQG
WR
G
E
R
D
TR
G
----
D
T
SWV
PP
-
EM
IERIEVLRGP
A
A
A
R
YGN
G
A
A
GGVVNIITKKG
S
--------------
GE
W
HG
S
WD
A
YF
N
AP
E
HK
E
E
---
G
----
AT
K
RT
NF
SLT
GPL
-
G
D
EFSF
R
LY
G
NLD
K
TQ
A
D
A
WDINQ
--
GHQSARAGTYA
T
T
L
PAGR
E
GVI
N
K
D
I
N
G
VV
--
R
W
D
F
A
P
L
Q
S
L
EL
E
AGY
SRQ
GNLYA
GDT
Q
NT
N
S
D
S
Y
TR
S
-
-KY
-----------------
G
D
E
T
N
R
L
YR
QNYALTWNGGWDN
G
V
TTSNWVQ
Y
EH
T
R
---------
N
---------
-
S
R
---
IPE
GL
A
G
GTE
GKFNEKA
T
QDFV
DIDL
D
DVMLH
SE
V
NL
PI
DFLVNQ
T
L
T
L
G
T
EW
NQQ
R
MK
D
LSSNTQA
L
TGTNTG
G
AI
D
G
VSTTDRSPYSKA
E
IF
SL
---
-
--
FAE
NNME
LTD
S
T
I
V
T
P
G
L
R
F
--------
DH
------------
HSIV
GN
----------
N
WSP
ALN
I
SQG
L
G
D
D
F
T
LK
M
G
IA
R
A
YKAP
S
L
Y
Q
TNPNYI
L
YSKGQ
G
CYA
--
SA
G
GCY
L
-----
Q
GN
D
DLK
A
E
T
S
I
N
K
EIG
LEF-KRD
G
W
L
A
G
VT
W
F
R
N
D
YR
NKI
E
A
GYVAVGQ
N
A
VGTDLYQ
W
D
N
V
P
KA
V
VE
G
L
E
G
S
LNV
P
-
VSE
T
VMWTN
N
I
T
Y
M
-------
LK
SE
N
KT
---
T
G
D
----
RLS
I
IPEY
T
L
N
S
T
L
S
W
QAR
E
DLSMQTTF
T
WY
GK
QQ
P
KKY
-
NY
KGQP
AV
-----
G
PE
T
KEISP
Y
S
I
VGL
SAT
W
D
V
T
K
---
N
V
S
L
TGG
VDNLFDK
-
-
---R
L
WRA
G
N
AQT
TGDL
AG
ANYIA
G
A
G
A
---
Y
T
Y
NE
PGR
TW
Y
MSVN
TH
F
fig|511145.12.peg.609
Escherichia coli str. K-12 substr. MG1655 (47-746/746)
A
P
G
VS
T
I
TA
D
EIR
K
N
-
PVAR
D
V
S
K
I
I
R
T
-
M
PGV
N
L
TGN
S
TS
G
QR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
K
P
VSSRNS
VRQG
WR
G
E
R
D
TR
G
----
D
T
SWV
PP
-
EM
IERIEVLRGP
A
A
A
R
YGN
G
A
A
GGVVNIITKKG
S
--------------
GE
W
HG
S
WD
A
YF
N
AP
E
HK
E
E
---
G
----
AT
K
RT
NF
SLT
GPL
-
G
D
EFSF
R
LY
G
NLD
K
TQ
A
D
A
WDINQ
--
GHQSARAGTYA
T
T
L
PAGR
E
GVI
N
K
D
I
N
G
VV
--
R
W
D
F
A
P
L
Q
S
L
EL
E
AGY
SRQ
GNLYA
GDT
Q
NT
N
S
D
S
Y
TR
S
-
-KY
-----------------
G
D
E
T
N
R
L
YR
QNYALTWNGGWDN
G
V
TTSNWVQ
Y
EH
T
R
---------
N
---------
-
S
R
---
IPE
GL
A
G
GTE
GKFNEKA
T
QDFV
DIDL
D
DVMLH
SE
V
NL
PI
DFLVNQ
T
L
T
L
G
T
EW
NQQ
R
MK
D
LSSNTQA
L
TGTNTG
G
AI
D
G
VSTTDRSPYSKA
E
IF
SL
---
-
--
FAE
NNME
LTD
S
T
I
V
T
P
G
L
R
F
--------
DH
------------
HSIV
GN
----------
N
WSP
ALN
I
SQG
L
G
D
D
F
T
LK
M
G
IA
R
A
YKAP
S
L
Y
Q
TNPNYI
L
YSKGQ
G
CYA
--
SA
G
GCY
L
-----
Q
GN
D
DLK
A
E
T
S
I
N
K
EIG
LEF-KRD
G
W
L
A
G
VT
W
F
R
N
D
YR
NKI
E
A
GYVAVGQ
N
A
VGTDLYQ
W
D
N
V
P
KA
V
VE
G
L
E
G
S
LNV
P
-
VSE
T
VMWTN
N
I
T
Y
M
-------
LK
SE
N
KT
---
T
G
D
----
RLS
I
IPEY
T
L
N
S
T
L
S
W
QAR
E
DLSMQTTF
T
WY
GK
QQ
P
KKY
-
NY
KGQP
AV
-----
G
PE
T
KEISP
Y
S
I
VGL
SAT
W
D
V
T
K
---
N
V
S
L
TGG
VDNLFDK
-
-
---R
L
WRA
G
N
AQT
TGDL
AG
ANYIA
G
A
G
A
---
Y
T
Y
NE
PGR
TW
Y
MSVN
TH
F
fig|511145.6.peg.600
Escherichia coli str. K-12 substr. MG1655 (47-746/746)
A
P
G
VS
T
I
TA
D
EIR
K
N
-
PVAR
D
V
S
K
I
I
R
T
-
M
PGV
N
L
TGN
S
TS
G
QR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
K
P
VSSRNS
VRQG
WR
G
E
R
D
TR
G
----
D
T
SWV
PP
-
EM
IERIEVLRGP
A
A
A
R
YGN
G
A
A
GGVVNIITKKG
S
--------------
GE
W
HG
S
WD
A
YF
N
AP
E
HK
E
E
---
G
----
AT
K
RT
NF
SLT
GPL
-
G
D
EFSF
R
LY
G
NLD
K
TQ
A
D
A
WDINQ
--
GHQSARAGTYA
T
T
L
PAGR
E
GVI
N
K
D
I
N
G
VV
--
R
W
D
F
A
P
L
Q
S
L
EL
E
AGY
SRQ
GNLYA
GDT
Q
NT
N
S
D
S
Y
TR
S
-
-KY
-----------------
G
D
E
T
N
R
L
YR
QNYALTWNGGWDN
G
V
TTSNWVQ
Y
EH
T
R
---------
N
---------
-
S
R
---
IPE
GL
A
G
GTE
GKFNEKA
T
QDFV
DIDL
D
DVMLH
SE
V
NL
PI
DFLVNQ
T
L
T
L
G
T
EW
NQQ
R
MK
D
LSSNTQA
L
TGTNTG
G
AI
D
G
VSTTDRSPYSKA
E
IF
SL
---
-
--
FAE
NNME
LTD
S
T
I
V
T
P
G
L
R
F
--------
DH
------------
HSIV
GN
----------
N
WSP
ALN
I
SQG
L
G
D
D
F
T
LK
M
G
IA
R
A
YKAP
S
L
Y
Q
TNPNYI
L
YSKGQ
G
CYA
--
SA
G
GCY
L
-----
Q
GN
D
DLK
A
E
T
S
I
N
K
EIG
LEF-KRD
G
W
L
A
G
VT
W
F
R
N
D
YR
NKI
E
A
GYVAVGQ
N
A
VGTDLYQ
W
D
N
V
P
KA
V
VE
G
L
E
G
S
LNV
P
-
VSE
T
VMWTN
N
I
T
Y
M
-------
LK
SE
N
KT
---
T
G
D
----
RLS
I
IPEY
T
L
N
S
T
L
S
W
QAR
E
DLSMQTTF
T
WY
GK
QQ
P
KKY
-
NY
KGQP
AV
-----
G
PE
T
KEISP
Y
S
I
VGL
SAT
W
D
V
T
K
---
N
V
S
L
TGG
VDNLFDK
-
-
---R
L
WRA
G
N
AQT
TGDL
AG
ANYIA
G
A
G
A
---
Y
T
Y
NE
PGR
TW
Y
MSVN
TH
F
fig|670897.3.peg.162
Escherichia coli 2362-75 (47-746/746)
A
P
G
VS
T
I
TA
D
EIR
K
N
-
PVAR
D
V
SE
I
I
R
T
-
M
PGV
N
L
TGN
S
TS
G
QR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
K
P
VSSRNS
VRQG
WR
G
E
R
D
TR
G
----
D
T
SWV
PP
-
EM
IERIEVLRGP
A
A
A
R
YGN
G
A
A
GGVVNIITKKG
S
--------------
GE
W
HG
S
WD
A
YF
N
AP
E
HK
E
E
---
G
----
AT
K
RT
NF
SLT
GPL
-
G
D
EFSF
R
LY
G
NLD
K
TQ
A
D
A
WDINQ
--
GHQSARAGTYA
T
T
L
PAGR
E
GVI
N
K
D
I
N
G
VV
--
R
W
D
F
A
P
L
Q
S
L
EL
E
AGY
SRQ
GNLYA
GDT
Q
NT
N
S
D
A
Y
TR
S
-
-KY
-----------------
G
D
E
T
N
R
L
YR
QNYSLTWNGGWDN
G
V
TTSNWVQ
Y
EH
T
R
---------
N
---------
-
S
R
---
IPE
GL
A
G
GTE
GKFNEKA
A
QDFV
DIDL
D
DVMLH
SE
V
NL
PI
DFLVNQ
T
L
T
L
G
T
EW
NQQ
R
MK
D
LSSNTQA
L
TGTNTG
G
AI
D
G
VSATDRSPYSKA
E
IF
SL
---
-
--
FAE
NNME
LTD
S
T
I
V
T
P
G
L
R
F
--------
DH
------------
HSIV
GN
----------
N
WSP
ALN
I
SQG
L
G
Y
D
F
T
LK
M
G
IA
R
A
YKAP
S
L
Y
Q
TNPNYI
L
YSKGQ
G
CYA
--
SA
G
GCY
L
-----
Q
GN
D
DLK
A
E
T
S
I
N
K
EIG
LEF-KRD
G
W
L
A
G
VT
W
F
R
N
D
YR
NKI
E
A
GYVAVGQ
N
A
VGTDLYQ
W
D
N
V
P
KA
V
VE
G
L
E
G
S
LNV
P
-
VSE
T
VMWTN
N
I
T
Y
M
-------
LK
SE
N
KT
---
T
G
D
----
RLS
I
IPEY
T
L
N
S
T
L
S
W
QAR
E
DLSMQTTF
T
WY
GK
QQ
P
KKY
-
NY
KGQP
AV
-----
G
PE
T
KEISP
Y
S
I
VGL
SAT
W
D
V
T
K
---
N
V
S
L
TGG
VDNLFDK
-
-
---R
L
WRA
G
N
AQT
TGDL
AG
ANYIA
G
A
G
A
---
Y
T
Y
NE
PGR
TW
Y
MS
I
N
TH
F
fig|340185.3.peg.1754
Escherichia coli E22 (47-746/746)
A
P
G
VS
T
I
TA
D
EIR
K
N
-
PVAR
D
V
SE
I
I
R
T
-
M
PGV
N
L
TGN
S
TS
G
QR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
K
P
VSSRNS
VRQG
WR
G
E
R
D
TR
G
----
D
T
SWV
PP
-
EM
IERIEVLRGP
A
A
A
R
YGN
G
A
A
GGVVNIITKKG
S
--------------
GE
W
HG
S
WD
A
YF
N
AP
E
HK
E
E
---
G
----
AT
K
RT
NF
SLT
GPL
-
G
D
EFSF
R
LY
G
NLD
K
TQ
A
D
A
WDINQ
--
GHQSARAGTYV
T
T
L
PAGR
E
GVI
N
K
D
I
N
G
VV
--
R
W
D
F
A
P
L
Q
S
L
EL
E
AGY
SRQ
GNLYA
GDT
Q
NT
N
S
D
A
Y
TR
S
-
-KY
-----------------
G
D
E
T
N
R
L
YR
QNYALTWNGGWDN
G
V
TTSNWVQ
Y
EH
T
R
---------
N
---------
-
S
R
---
IPE
GL
A
G
GTE
GKFNEKA
T
QDFV
DIDL
D
DVMLH
SE
V
NL
PI
DFLVNQ
T
L
T
L
G
T
EW
NQQ
R
MK
D
LSSNTQA
L
TGANTG
G
AI
D
G
VSATDRSPYSKA
E
IF
SL
---
-
--
FAE
NNME
LTD
S
T
I
V
T
P
G
L
R
F
--------
DH
------------
HSIV
GN
----------
N
WSP
ALN
I
SQG
L
G
D
D
F
T
LK
M
G
IA
R
A
YKAP
S
L
Y
Q
TNPNYI
L
YSKGQ
G
CYA
--
SA
G
GCY
L
-----
Q
GN
D
DLK
A
E
T
S
I
N
K
EIG
LEF-KRD
G
W
L
A
G
VT
W
F
R
N
D
YR
NKI
E
A
GYVAVGQ
N
A
VGTDLYQ
W
D
N
V
P
KA
V
VE
G
L
E
G
S
LNV
P
-
VSE
T
VMWTN
N
I
T
Y
M
-------
LK
S
K
N
KT
---
T
G
D
----
RLS
I
IPEY
T
L
N
S
T
L
S
W
QAR
E
DLSMQTTF
T
WY
GK
QQ
P
KKY
-
NY
KGQP
AV
-----
G
PE
T
KEISP
Y
S
I
VGL
SAT
W
D
V
T
K
---
N
V
S
L
TGG
VDNLFDK
-
-
---R
L
WRA
G
N
AQT
TGDL
AG
ANYIA
G
A
G
A
---
Y
T
Y
NE
PGR
TW
Y
MSVN
TH
F
fig|340185.4.peg.1848
Escherichia coli E22 (47-746/746)
A
P
G
VS
T
I
TA
D
EIR
K
N
-
PVAR
D
V
SE
I
I
R
T
-
M
PGV
N
L
TGN
S
TS
G
QR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
K
P
VSSRNS
VRQG
WR
G
E
R
D
TR
G
----
D
T
SWV
PP
-
EM
IERIEVLRGP
A
A
A
R
YGN
G
A
A
GGVVNIITKKG
S
--------------
GE
W
HG
S
WD
A
YF
N
AP
E
HK
E
E
---
G
----
AT
K
RT
NF
SLT
GPL
-
G
D
EFSF
R
LY
G
NLD
K
TQ
A
D
A
WDINQ
--
GHQSARAGTYV
T
T
L
PAGR
E
GVI
N
K
D
I
N
G
VV
--
R
W
D
F
A
P
L
Q
S
L
EL
E
AGY
SRQ
GNLYA
GDT
Q
NT
N
S
D
A
Y
TR
S
-
-KY
-----------------
G
D
E
T
N
R
L
YR
QNYALTWNGGWDN
G
V
TTSNWVQ
Y
EH
T
R
---------
N
---------
-
S
R
---
IPE
GL
A
G
GTE
GKFNEKA
T
QDFV
DIDL
D
DVMLH
SE
V
NL
PI
DFLVNQ
T
L
T
L
G
T
EW
NQQ
R
MK
D
LSSNTQA
L
TGANTG
G
AI
D
G
VSATDRSPYSKA
E
IF
SL
---
-
--
FAE
NNME
LTD
S
T
I
V
T
P
G
L
R
F
--------
DH
------------
HSIV
GN
----------
N
WSP
ALN
I
SQG
L
G
D
D
F
T
LK
M
G
IA
R
A
YKAP
S
L
Y
Q
TNPNYI
L
YSKGQ
G
CYA
--
SA
G
GCY
L
-----
Q
GN
D
DLK
A
E
T
S
I
N
K
EIG
LEF-KRD
G
W
L
A
G
VT
W
F
R
N
D
YR
NKI
E
A
GYVAVGQ
N
A
VGTDLYQ
W
D
N
V
P
KA
V
VE
G
L
E
G
S
LNV
P
-
VSE
T
VMWTN
N
I
T
Y
M
-------
LK
S
K
N
KT
---
T
G
D
----
RLS
I
IPEY
T
L
N
S
T
L
S
W
QAR
E
DLSMQTTF
T
WY
GK
QQ
P
KKY
-
NY
KGQP
AV
-----
G
PE
T
KEISP
Y
S
I
VGL
SAT
W
D
V
T
K
---
N
V
S
L
TGG
VDNLFDK
-
-
---R
L
WRA
G
N
AQT
TGDL
AG
ANYIA
G
A
G
A
---
Y
T
Y
NE
PGR
TW
Y
MSVN
TH
F
fig|585395.4.peg.619
Escherichia coli O103:H2 str. 12009 (47-746/746)
A
P
G
VS
T
I
TA
D
EIR
K
N
-
PVAR
D
V
SE
I
I
R
T
-
M
PGV
N
L
TGN
S
TS
G
QR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
K
P
VSSRNS
VRQG
WR
G
E
R
D
TR
G
----
D
T
SWV
PP
-
EM
IERIEVLRGP
A
A
A
R
YGN
G
A
A
GGVVNIITKKG
S
--------------
GE
W
HG
S
WD
A
YF
N
AP
E
HK
E
E
---
G
----
AT
K
RT
NF
SLT
GPL
-
G
D
EFSF
R
LY
G
NLD
K
TQ
A
D
A
WDINQ
--
GHQSARAGTYV
T
T
L
PAGR
E
GVI
N
K
D
I
N
G
VV
--
R
W
D
F
A
P
L
Q
S
L
EL
E
AGY
SRQ
GNLYA
GDT
Q
NT
N
S
D
A
Y
TR
S
-
-KY
-----------------
G
D
E
T
N
R
L
YR
QNYALTWNGGWDN
G
V
TTSNWVQ
Y
EH
T
R
---------
N
---------
-
S
R
---
IPE
GL
A
G
GTE
GKFNEKA
T
QDFV
DIDL
D
DVMLH
SE
V
NL
PI
DFLVNQ
T
L
T
L
G
T
EW
NQQ
R
MK
D
LSSNTQA
L
TGANTG
G
AI
D
G
VSATDRSPYSKA
E
IF
SL
---
-
--
FAE
NNME
LTD
S
T
I
V
T
P
G
L
R
F
--------
DH
------------
HSIV
GN
----------
N
WSP
ALN
I
SQG
L
G
D
D
F
T
LK
M
G
IA
R
A
YKAP
S
L
Y
Q
TNPNYI
L
YSKGQ
G
CYA
--
SA
G
GCY
L
-----
Q
GN
D
DLK
A
E
T
S
I
N
K
EIG
LEF-KRD
G
W
L
A
G
VT
W
F
R
N
D
YR
NKI
E
A
GYVAVGQ
N
A
VGTDLYQ
W
D
N
V
P
KA
V
VE
G
L
E
G
S
LNV
P
-
VSE
T
VMWTN
N
I
T
Y
M
-------
LK
S
K
N
KT
---
T
G
D
----
RLS
I
IPEY
T
L
N
S
T
L
S
W
QAR
E
DLSMQTTF
T
WY
GK
QQ
P
KKY
-
NY
KGQP
AV
-----
G
PE
T
KEISP
Y
S
I
VGL
SAT
W
D
V
T
K
---
N
V
S
L
TGG
VDNLFDK
-
-
---R
L
WRA
G
N
AQT
TGDL
AG
ANYIA
G
A
G
A
---
Y
T
Y
NE
PGR
TW
Y
MSVN
TH
F
fig|344601.3.peg.2287
Escherichia coli B171 (47-746/746)
A
P
G
VS
T
I
TA
D
EIR
K
N
-
PVAR
D
V
SE
I
I
R
T
-
M
PGV
N
L
TGN
S
TS
G
QR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
K
P
VSSRNS
VRQG
WR
G
E
R
D
TR
G
----
D
T
SWV
PP
-
EM
IERIEVLRGP
A
A
A
R
YGN
G
A
A
GGVVNIITKKG
S
--------------
GE
W
HG
S
WD
A
YF
N
AP
E
HK
E
E
---
G
----
AT
K
RT
NF
SLT
GPL
-
G
D
EFSF
R
LY
G
NLD
K
TQ
A
D
A
WDINQ
--
GHQSARAGTYV
T
T
L
PAGR
E
GVI
N
K
D
I
N
G
VV
--
R
W
D
F
A
P
L
Q
S
L
EL
E
AGY
SRQ
GNLYA
GDT
Q
NT
N
S
D
A
Y
TR
S
-
-KY
-----------------
G
D
E
T
N
R
L
YR
QNYALTWNGGWDN
G
V
TTSNWVQ
Y
EH
T
R
---------
N
---------
-
S
R
---
IPE
GL
A
G
GTE
GKFNEKA
T
QDFV
DIDL
D
DVMLH
SE
V
NL
PI
DFLVNQ
T
L
T
L
G
T
EW
NQQ
R
MK
D
LSSNTQA
L
TGANTG
G
AI
D
G
VSATDRSPYSKA
E
IF
SL
---
-
--
FAE
NNME
LTD
S
T
I
V
T
P
G
L
R
F
--------
DH
------------
HSIV
GN
----------
N
WSP
ALN
I
SQG
L
G
D
D
F
T
LK
M
G
IA
R
A
YKAP
S
L
Y
Q
TNPNYI
L
YSKGQ
G
CYA
--
SA
G
GCY
L
-----
Q
GN
D
DLK
A
E
T
S
I
N
K
EIG
LEF-KRD
G
W
L
A
G
VT
W
F
R
N
D
YR
NKI
E
A
GYVAVGQ
N
A
VGTDLYQ
W
D
N
V
P
KA
V
VE
G
L
E
G
S
LNV
P
-
VSE
T
VMWTN
N
I
T
Y
M
-------
LK
SE
N
KT
---
T
G
D
----
RLS
I
IPEY
T
L
N
S
T
L
S
W
QAR
E
DLSMQTTF
T
WY
GK
QQ
P
KKY
-
NY
KGQP
AV
-----
G
PE
T
KEISP
Y
S
I
VGL
SAT
W
D
V
T
K
---
N
V
S
L
TGG
VDNLFDK
-
-
---R
L
WRA
G
N
AQT
TGDL
A
R
ANYIA
G
A
G
A
---
Y
T
Y
NE
PGR
TW
Y
MSVN
TH
F
fig|344601.5.peg.2388
Escherichia coli B171 (47-746/746)
A
P
G
VS
T
I
TA
D
EIR
K
N
-
PVAR
D
V
SE
I
I
R
T
-
M
PGV
N
L
TGN
S
TS
G
QR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
K
P
VSSRNS
VRQG
WR
G
E
R
D
TR
G
----
D
T
SWV
PP
-
EM
IERIEVLRGP
A
A
A
R
YGN
G
A
A
GGVVNIITKKG
S
--------------
GE
W
HG
S
WD
A
YF
N
AP
E
HK
E
E
---
G
----
AT
K
RT
NF
SLT
GPL
-
G
D
EFSF
R
LY
G
NLD
K
TQ
A
D
A
WDINQ
--
GHQSARAGTYV
T
T
L
PAGR
E
GVI
N
K
D
I
N
G
VV
--
R
W
D
F
A
P
L
Q
S
L
EL
E
AGY
SRQ
GNLYA
GDT
Q
NT
N
S
D
A
Y
TR
S
-
-KY
-----------------
G
D
E
T
N
R
L
YR
QNYALTWNGGWDN
G
V
TTSNWVQ
Y
EH
T
R
---------
N
---------
-
S
R
---
IPE
GL
A
G
GTE
GKFNEKA
T
QDFV
DIDL
D
DVMLH
SE
V
NL
PI
DFLVNQ
T
L
T
L
G
T
EW
NQQ
R
MK
D
LSSNTQA
L
TGANTG
G
AI
D
G
VSATDRSPYSKA
E
IF
SL
---
-
--
FAE
NNME
LTD
S
T
I
V
T
P
G
L
R
F
--------
DH
------------
HSIV
GN
----------
N
WSP
ALN
I
SQG
L
G
D
D
F
T
LK
M
G
IA
R
A
YKAP
S
L
Y
Q
TNPNYI
L
YSKGQ
G
CYA
--
SA
G
GCY
L
-----
Q
GN
D
DLK
A
E
T
S
I
N
K
EIG
LEF-KRD
G
W
L
A
G
VT
W
F
R
N
D
YR
NKI
E
A
GYVAVGQ
N
A
VGTDLYQ
W
D
N
V
P
KA
V
VE
G
L
E
G
S
LNV
P
-
VSE
T
VMWTN
N
I
T
Y
M
-------
LK
SE
N
KT
---
T
G
D
----
RLS
I
IPEY
T
L
N
S
T
L
S
W
QAR
E
DLSMQTTF
T
WY
GK
QQ
P
KKY
-
NY
KGQP
AV
-----
G
PE
T
KEISP
Y
S
I
VGL
SAT
W
D
V
T
K
---
N
V
S
L
TGG
VDNLFDK
-
-
---R
L
WRA
G
N
AQT
TGDL
A
R
ANYIA
G
A
G
A
---
Y
T
Y
NE
PGR
TW
Y
MSVN
TH
F
fig|199310.1.peg.1207
Escherichia coli CFT073 (35-725/725)
LVV
EATAEQV
L
KQ
Q
P
G
VSVI
TS
E
D
I
K
K
T
-
PPVN
DLS
D
I
I
R
K
-
M
PGV
N
L
TGN
S
AS
G
TR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
V
P
VTSRNS
VR
YS
WR
G
E
R
D
TR
G
----
D
T
NWV
PP
-
EQ
V
ERIEV
I
RGP
A
A
A
R
YG
S
G
A
A
GGVVNIITK
R
P
T
--------------
ND
W
HG
S
LS
L
YT
N
QP
E
SS
E
E
---
G
----
AT
R
RA
NF
SLS
GPL
A
G
D
ALTT
R
LY
G
NLN
K
TD
A
D
S
WDIN
SPV
GTKNA------
-
-
-
-AGH
E
GVR
N
K
D
I
N
G
VV
--
S
WK
L
NPQQ
I
L
DF
E
VGY
SRQ
GN
I
YA
GDT
Q
NS
S
S
S
A
V
TE
SL
AKS
-----------------
G
K
E
T
N
R
L
YR
QNYGITHNGIWDW
G
-
QSRFGVY
Y
EK
T
N
---------
N
---------
-
T
R
---
MNE
GL
S
G
GGE
G
RI
--
L
A
G
EK
F
T
TNRL
S
SWRTS
G
EL
NI
P
L
NVMVDQ
T
L
T
V
G
A
EW
NRD
K
LD
D
PSSTSLT
V
NDRDIS
G
-
I
S
G
-SAADRSSKNHS
Q
IS
A
L
---
-
--
Y
I
E
DNIE
P
VP
G
T
N
I
I
P
G
L
R
F
--------
D
Y
------------
LSDS
G
G
----------
N
F
SP
SLN
L
SQE
L
G
D
Y
F
K
V
K
A
G
VA
R
T
F
KAP
N
L
Y
Q
SSEG
Y
L
L
YSKGN
G
CPK
DI
TS
G
GCY
L
-----
I
GN
K
DL
D
PE
I
S
V
N
K
EIG
LEF-TWE
D
Y
H
A
S
VT
Y
F
R
N
D
YQ
NKIV
A
G
DNVI
GQ
T
A
SGAYILK
W
Q
N
G
GKA
L
VD
G
I
E
A
S
MSF
P
L
VKE
R
LNWNT
N
A
TW
M
-------
IT
SEQ
KD
---
T
G
N
----
P
LS
V
IP
K
Y
T
I
N
N
S
L
N
W
TIT
Q
AFSASFNW
T
LY
G
R
QK
P
RTH
AET
RSED
TG
-----
G
LS
G
KELGA
Y
S
LVG
T
NFN
YD
I
N
K
---
N
L
R
L
NVG
V
S
N
I
LN
K
-
-
---Q
I
FRS
S
E
---
----
--
-----
-
-
G
A
---
N
T
Y
NE
PGR
A
Y
Y
A
G
V
T
AS
F
fig|199310.4.peg.1186
Escherichia coli CFT073 (35-725/725)
LVV
EATAEQV
L
KQ
Q
P
G
VSVI
TS
E
D
I
K
K
T
-
PPVN
DLS
D
I
I
R
K
-
M
PGV
N
L
TGN
S
AS
G
TR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
V
P
VTSRNS
VR
YS
WR
G
E
R
D
TR
G
----
D
T
NWV
PP
-
EQ
V
ERIEV
I
RGP
A
A
A
R
YG
S
G
A
A
GGVVNIITK
R
P
T
--------------
ND
W
HG
S
LS
L
YT
N
QP
E
SS
E
E
---
G
----
AT
R
RA
NF
SLS
GPL
A
G
D
ALTT
R
LY
G
NLN
K
TD
A
D
S
WDIN
SPV
GTKNA------
-
-
-
-AGH
E
GVR
N
K
D
I
N
G
VV
--
S
WK
L
NPQQ
I
L
DF
E
VGY
SRQ
GN
I
YA
GDT
Q
NS
S
S
S
A
V
TE
SL
AKS
-----------------
G
K
E
T
N
R
L
YR
QNYGITHNGIWDW
G
-
QSRFGVY
Y
EK
T
N
---------
N
---------
-
T
R
---
MNE
GL
S
G
GGE
G
RI
--
L
A
G
EK
F
T
TNRL
S
SWRTS
G
EL
NI
P
L
NVMVDQ
T
L
T
V
G
A
EW
NRD
K
LD
D
PSSTSLT
V
NDRDIS
G
-
I
S
G
-SAADRSSKNHS
Q
IS
A
L
---
-
--
Y
I
E
DNIE
P
VP
G
T
N
I
I
P
G
L
R
F
--------
D
Y
------------
LSDS
G
G
----------
N
F
SP
SLN
L
SQE
L
G
D
Y
F
K
V
K
A
G
VA
R
T
F
KAP
N
L
Y
Q
SSEG
Y
L
L
YSKGN
G
CPK
DI
TS
G
GCY
L
-----
I
GN
K
DL
D
PE
I
S
V
N
K
EIG
LEF-TWE
D
Y
H
A
S
VT
Y
F
R
N
D
YQ
NKIV
A
G
DNVI
GQ
T
A
SGAYILK
W
Q
N
G
GKA
L
VD
G
I
E
A
S
MSF
P
L
VKE
R
LNWNT
N
A
TW
M
-------
IT
SEQ
KD
---
T
G
N
----
P
LS
V
IP
K
Y
T
I
N
N
S
L
N
W
TIT
Q
AFSASFNW
T
LY
G
R
QK
P
RTH
AET
RSED
TG
-----
G
LS
G
KELGA
Y
S
LVG
T
NFN
YD
I
N
K
---
N
L
R
L
NVG
V
S
N
I
LN
K
-
-
---Q
I
FRS
S
E
---
----
--
-----
-
-
G
A
---
N
T
Y
NE
PGR
A
Y
Y
A
G
V
T
AS
F
fig|525281.3.peg.1457
Escherichia coli 83972 (35-725/725)
LVV
EATAEQV
L
KQ
Q
P
G
VSVI
TS
E
D
I
K
K
T
-
PPVN
DLS
D
I
I
R
K
-
M
PGV
N
L
TGN
S
AS
G
TR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
V
P
VTSRNS
VR
YS
WR
G
E
R
D
TR
G
----
D
T
NWV
PP
-
EQ
V
ERIEV
I
RGP
A
A
A
R
YG
S
G
A
A
GGVVNIITK
R
P
T
--------------
ND
W
HG
S
LS
L
YT
N
QP
E
SS
E
E
---
G
----
AT
R
RA
NF
SLS
GPL
A
G
D
ALTT
R
LY
G
NLN
K
TD
A
D
S
WDIN
SPV
GTKNA------
-
-
-
-AGH
E
GVR
N
K
D
I
N
G
VV
--
S
WK
L
NPQQ
I
L
DF
E
VGY
SRQ
GN
I
YA
GDT
Q
NS
S
S
S
A
V
TE
SL
AKS
-----------------
G
K
E
T
N
R
L
YR
QNYGITHNGIWDW
G
-
QSRFGVY
Y
EK
T
N
---------
N
---------
-
T
R
---
MNE
GL
S
G
GGE
G
RI
--
L
A
G
EK
F
T
TNRL
S
SWRTS
G
EL
NI
P
L
NVMVDQ
T
L
T
V
G
A
EW
NRD
K
LD
D
PSSTSLT
V
NDRDIS
G
-
I
S
G
-SAADRSSKNHS
Q
IS
A
L
---
-
--
Y
I
E
DNIE
P
VP
G
T
N
I
I
P
G
L
R
F
--------
D
Y
------------
LSDS
G
G
----------
N
F
SP
SLN
L
SQE
L
G
D
Y
F
K
V
K
A
G
VA
R
T
F
KAP
N
L
Y
Q
SSEG
Y
L
L
YSKGN
G
CPK
DI
TS
G
GCY
L
-----
I
GN
K
DL
D
PE
I
S
V
N
K
EIG
LEF-TWE
D
Y
H
A
S
VT
Y
F
R
N
D
YQ
NKIV
A
G
DNVI
GQ
T
A
SGAYILK
W
Q
N
G
GKA
L
VD
G
I
E
A
S
MSF
P
L
VKE
R
LNWNT
N
A
TW
M
-------
IT
SEQ
KD
---
T
G
N
----
P
LS
V
IP
K
Y
T
I
N
N
S
L
N
W
TIT
Q
AFSASFNW
T
LY
G
R
QK
P
RTH
AET
RSED
TG
-----
G
LS
G
KELGA
Y
S
LVG
T
NFN
YD
I
N
K
---
N
L
R
L
NVG
V
S
N
I
LN
K
-
-
---Q
I
FRS
S
E
---
----
--
-----
-
-
G
A
---
N
T
Y
NE
PGR
A
Y
Y
A
G
V
T
AS
F
fig|655817.3.peg.1278
Escherichia coli ABU 83972 (35-725/725)
LVV
EATAEQV
L
KQ
Q
P
G
VSVI
TS
E
D
I
K
K
T
-
PPVN
DLS
D
I
I
R
K
-
M
PGV
N
L
TGN
S
AS
G
TR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
V
P
VTSRNS
VR
YS
WR
G
E
R
D
TR
G
----
D
T
NWV
PP
-
EQ
V
ERIEV
I
RGP
A
A
A
R
YG
S
G
A
A
GGVVNIITK
R
P
T
--------------
ND
W
HG
S
LS
L
YT
N
QP
E
SS
E
E
---
G
----
AT
R
RA
NF
SLS
GPL
A
G
D
ALTT
R
LY
G
NLN
K
TD
A
D
S
WDIN
SPV
GTKNA------
-
-
-
-AGH
E
GVR
N
K
D
I
N
G
VV
--
S
WK
L
NPQQ
I
L
DF
E
VGY
SRQ
GN
I
YA
GDT
Q
NS
S
S
S
A
V
TE
SL
AKS
-----------------
G
K
E
T
N
R
L
YR
QNYGITHNGIWDW
G
-
QSRFGVY
Y
EK
T
N
---------
N
---------
-
T
R
---
MNE
GL
S
G
GGE
G
RI
--
L
A
G
EK
F
T
TNRL
S
SWRTS
G
EL
NI
P
L
NVMVDQ
T
L
T
V
G
A
EW
NRD
K
LD
D
PSSTSLT
V
NDRDIS
G
-
I
S
G
-SAADRSSKNHS
Q
IS
A
L
---
-
--
Y
I
E
DNIE
P
VP
G
T
N
I
I
P
G
L
R
F
--------
D
Y
------------
LSDS
G
G
----------
N
F
SP
SLN
L
SQE
L
G
D
Y
F
K
V
K
A
G
VA
R
T
F
KAP
N
L
Y
Q
SSEG
Y
L
L
YSKGN
G
CPK
DI
TS
G
GCY
L
-----
I
GN
K
DL
D
PE
I
S
V
N
K
EIG
LEF-TWE
D
Y
H
A
S
VT
Y
F
R
N
D
YQ
NKIV
A
G
DNVI
GQ
T
A
SGAYILK
W
Q
N
G
GKA
L
VD
G
I
E
A
S
MSF
P
L
VKE
R
LNWNT
N
A
TW
M
-------
IT
SEQ
KD
---
T
G
N
----
P
LS
V
IP
K
Y
T
I
N
N
S
L
N
W
TIT
Q
AFSASFNW
T
LY
G
R
QK
P
RTH
AET
RSED
TG
-----
G
LS
G
KELGA
Y
S
LVG
T
NFN
YD
I
N
K
---
N
L
R
L
NVG
V
S
N
I
LN
K
-
-
---Q
I
FRS
S
E
---
----
--
-----
-
-
G
A
---
N
T
Y
NE
PGR
A
Y
Y
A
G
V
T
AS
F
fig|749528.3.peg.2530
Escherichia coli MS 45-1 (16-690/690)
VSVI
TS
E
D
I
K
K
T
-
PPVN
DLS
D
I
I
R
K
-
M
PGV
N
L
TGN
S
AS
G
TR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
V
P
VTSRNS
VR
YS
WR
G
E
R
D
TR
G
----
D
T
NWV
PP
-
EQ
V
ERIEV
I
RGP
A
A
A
R
YG
S
G
A
A
GGVVNIITK
R
P
T
--------------
ND
W
HG
S
LS
L
YT
N
QP
E
SS
E
E
---
G
----
AT
R
RA
NF
SLS
GPL
A
G
D
ALTT
R
LY
G
NLN
K
TD
A
D
S
WDIN
SPV
GTKNA------
-
-
-
-AGH
E
GVR
N
K
D
I
N
G
VV
--
S
WK
L
NPQQ
I
L
DF
E
VGY
SRQ
GN
I
YA
GDT
Q
NS
S
S
S
A
V
TE
SL
AKS
-----------------
G
K
E
T
N
R
L
YR
QNYGITHNGIWDW
G
-
QSRFGVY
Y
EK
T
N
---------
N
---------
-
T
R
---
MNE
GL
S
G
GGE
G
RI
--
L
A
G
EK
F
T
TNRL
S
SWRTS
G
EL
NI
P
L
NVMVDQ
T
L
T
V
G
A
EW
NRD
K
LD
D
PSSTSLT
V
NDRDIS
G
-
I
S
G
-SAADRSSKNHS
Q
IS
A
L
---
-
--
Y
I
E
DNIE
P
VP
G
T
N
I
I
P
G
L
R
F
--------
D
Y
------------
LSDS
G
G
----------
N
F
SP
SLN
L
SQE
L
G
D
Y
F
K
V
K
A
G
VA
R
T
F
KAP
N
L
Y
Q
SSEG
Y
L
L
YSKGN
G
CPK
DI
TS
G
GCY
L
-----
I
GN
K
DL
D
PE
I
S
V
N
K
EIG
LEF-TWE
D
Y
H
A
S
VT
Y
F
R
N
D
YQ
NKIV
A
G
DNVI
GQ
T
A
SGAYILK
W
Q
N
G
GKA
L
VD
G
I
E
A
S
MSF
P
L
VKE
R
LNWNT
N
A
TW
M
-------
IT
SEQ
KD
---
T
G
N
----
P
LS
V
IP
K
Y
T
I
N
N
S
L
N
W
TIT
Q
AFSASFNW
T
LY
G
R
QK
P
RTH
AET
RSED
TG
-----
G
LS
G
KELGA
Y
S
LVG
T
NFN
YD
I
N
K
---
N
L
R
L
NVG
V
S
N
I
LN
K
-
-
---Q
I
FRS
S
E
---
----
--
-----
-
-
G
A
---
N
T
Y
NE
PGR
A
Y
Y
A
G
V
T
AS
F
fig|362663.8.peg.300
Escherichia coli 536 (35-725/725)
LVV
EATAEQV
L
KQ
Q
P
G
VSVI
TS
E
D
I
K
K
T
-
PPVN
DLS
D
I
I
R
K
-
M
PGV
N
L
TGN
S
AS
G
TR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
V
P
VTSRNS
VR
YS
WR
G
E
R
D
TR
G
----
D
T
NWV
PP
-
EQ
V
ERIEV
I
RGP
A
A
A
R
YG
S
G
A
A
GGVVNIITK
R
P
T
--------------
ND
W
HG
S
LS
L
YT
N
QP
E
SS
E
E
---
G
----
AT
R
RA
NF
SLS
GPL
A
G
D
ALTT
R
LY
G
NLN
K
TD
A
D
S
WDIN
SPV
GTKNA------
-
-
-
-AGH
E
GVR
N
K
D
I
N
G
VI
--
S
WK
L
NPQQ
I
L
DF
E
AGY
SRQ
GN
I
YA
GDT
Q
NS
S
S
S
A
V
TE
SL
AKS
-----------------
G
K
E
T
N
R
L
YR
QNYGITHNGIWDW
G
-
QSRFGIY
Y
EK
T
N
---------
N
---------
-
T
R
---
MNE
GL
S
G
GGE
G
RI
--
L
A
G
EK
F
T
TNRL
S
SWRTS
G
EL
NI
P
L
NVMVDQ
T
L
T
V
G
A
EW
NRD
K
LD
D
PSSTSLT
V
NDRDIS
G
-
I
S
G
-SAADRSSKNHS
Q
IS
A
L
---
-
--
Y
I
E
DNIE
P
VP
G
T
N
I
I
P
G
L
R
F
--------
D
Y
------------
LSDS
G
G
----------
N
F
SP
SLN
L
SQE
L
G
D
Y
F
K
V
K
A
G
VA
R
T
F
KAP
N
L
Y
Q
SSEG
Y
L
L
YSKGN
G
CPK
DI
TS
G
GCY
L
-----
I
GN
K
DL
D
PE
I
S
V
N
K
EIG
LEF-TWE
D
Y
H
A
S
VT
Y
F
R
N
D
YQ
NKIV
A
G
DNVI
GQ
T
A
SGAYILK
W
Q
N
G
GKA
L
VD
G
I
E
A
S
MSF
P
L
VKD
R
LNWNT
N
A
TW
M
-------
IT
SEQ
KD
---
T
G
N
----
P
LS
V
IP
K
Y
T
I
N
N
S
L
N
W
TIT
Q
AFSANVNW
T
LY
G
R
QK
P
RTH
AET
RSED
TG
-----
G
LS
G
KELGA
Y
S
LVG
T
NFN
YD
I
N
K
---
N
L
R
L
NVG
V
S
N
I
LN
K
-
-
---Q
I
FRS
S
E
---
----
--
-----
-
-
G
A
---
N
T
Y
NE
PGR
A
Y
Y
A
G
V
T
AS
F
fig|362663.9.peg.299
Escherichia coli 536 (35-725/725)
LVV
EATAEQV
L
KQ
Q
P
G
VSVI
TS
E
D
I
K
K
T
-
PPVN
DLS
D
I
I
R
K
-
M
PGV
N
L
TGN
S
AS
G
TR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
V
P
VTSRNS
VR
YS
WR
G
E
R
D
TR
G
----
D
T
NWV
PP
-
EQ
V
ERIEV
I
RGP
A
A
A
R
YG
S
G
A
A
GGVVNIITK
R
P
T
--------------
ND
W
HG
S
LS
L
YT
N
QP
E
SS
E
E
---
G
----
AT
R
RA
NF
SLS
GPL
A
G
D
ALTT
R
LY
G
NLN
K
TD
A
D
S
WDIN
SPV
GTKNA------
-
-
-
-AGH
E
GVR
N
K
D
I
N
G
VI
--
S
WK
L
NPQQ
I
L
DF
E
AGY
SRQ
GN
I
YA
GDT
Q
NS
S
S
S
A
V
TE
SL
AKS
-----------------
G
K
E
T
N
R
L
YR
QNYGITHNGIWDW
G
-
QSRFGIY
Y
EK
T
N
---------
N
---------
-
T
R
---
MNE
GL
S
G
GGE
G
RI
--
L
A
G
EK
F
T
TNRL
S
SWRTS
G
EL
NI
P
L
NVMVDQ
T
L
T
V
G
A
EW
NRD
K
LD
D
PSSTSLT
V
NDRDIS
G
-
I
S
G
-SAADRSSKNHS
Q
IS
A
L
---
-
--
Y
I
E
DNIE
P
VP
G
T
N
I
I
P
G
L
R
F
--------
D
Y
------------
LSDS
G
G
----------
N
F
SP
SLN
L
SQE
L
G
D
Y
F
K
V
K
A
G
VA
R
T
F
KAP
N
L
Y
Q
SSEG
Y
L
L
YSKGN
G
CPK
DI
TS
G
GCY
L
-----
I
GN
K
DL
D
PE
I
S
V
N
K
EIG
LEF-TWE
D
Y
H
A
S
VT
Y
F
R
N
D
YQ
NKIV
A
G
DNVI
GQ
T
A
SGAYILK
W
Q
N
G
GKA
L
VD
G
I
E
A
S
MSF
P
L
VKD
R
LNWNT
N
A
TW
M
-------
IT
SEQ
KD
---
T
G
N
----
P
LS
V
IP
K
Y
T
I
N
N
S
L
N
W
TIT
Q
AFSANVNW
T
LY
G
R
QK
P
RTH
AET
RSED
TG
-----
G
LS
G
KELGA
Y
S
LVG
T
NFN
YD
I
N
K
---
N
L
R
L
NVG
V
S
N
I
LN
K
-
-
---Q
I
FRS
S
E
---
----
--
-----
-
-
G
A
---
N
T
Y
NE
PGR
A
Y
Y
A
G
V
T
AS
F
fig|340197.3.peg.1359
Escherichia coli F11 (35-725/725)
LVV
EATAEQV
L
KQ
Q
P
G
VSVI
TS
E
D
I
K
K
T
-
PPVN
DLS
D
I
I
R
K
-
M
PGV
N
L
TGN
S
AS
G
TR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
V
P
VTSRNS
VR
YS
WR
G
E
R
D
TR
G
----
D
T
NWV
PP
-
EQ
V
ERIEV
I
RGP
A
A
A
R
YG
S
G
A
A
GGVVNIITK
R
P
T
--------------
ND
W
HG
S
LS
L
YT
N
QP
E
SS
E
E
---
G
----
AT
R
RA
NF
SLS
GPL
A
G
D
ALTT
R
LY
G
NLN
K
TD
A
D
S
WDIN
SPV
GTKNA------
-
-
-
-AGH
E
GVR
N
K
D
I
N
G
VI
--
S
WK
L
NPQQ
I
L
DF
E
AGY
SRQ
GN
I
YA
GDT
Q
NS
S
S
S
A
V
TE
SL
AKS
-----------------
G
K
E
T
N
R
L
YR
QNYGITHNGIWDW
G
-
QSRFGIY
Y
EK
T
N
---------
N
---------
-
T
R
---
MNE
GL
S
G
GGE
G
RI
--
L
A
G
EK
F
T
TNRL
S
SWRTS
G
EL
NI
P
L
NVMVDQ
T
L
T
V
G
A
EW
NRD
K
LD
D
PSSTSLT
V
NDRDIS
G
-
I
S
G
-SAADRSSKNHS
Q
IS
A
L
---
-
--
Y
I
E
DNIE
P
VP
G
T
N
I
I
P
G
L
R
F
--------
D
Y
------------
LSDS
G
G
----------
N
F
SP
SLN
L
SQE
L
G
D
Y
F
K
V
K
A
G
VA
R
T
F
KAP
N
L
Y
Q
SSEG
Y
L
L
YSKGN
G
CPK
DI
TS
G
GCY
L
-----
I
GN
K
DL
D
PE
I
S
V
N
K
EIG
LEF-TWE
D
Y
H
A
S
VT
Y
F
R
N
D
YQ
NKIV
A
G
DNVI
GQ
T
A
SGAYILK
W
Q
N
G
GKA
L
VD
G
I
E
A
S
MSF
P
L
VKD
R
LNWNT
N
A
TW
M
-------
IT
SEQ
KD
---
T
G
N
----
P
LS
V
IP
K
Y
T
I
N
N
S
L
N
W
TIT
Q
AFSANVNW
T
LY
G
R
QK
P
RTH
AET
RSED
TG
-----
G
LS
G
KELGA
Y
S
LVG
T
NFN
YD
I
N
K
---
N
L
R
L
NVG
V
S
N
I
LN
K
-
-
---Q
I
FRS
S
E
---
----
--
-----
-
-
G
A
---
N
T
Y
NE
PGR
A
Y
Y
A
G
V
T
AS
F
fig|340197.5.peg.1435
Escherichia coli F11 (35-725/725)
LVV
EATAEQV
L
KQ
Q
P
G
VSVI
TS
E
D
I
K
K
T
-
PPVN
DLS
D
I
I
R
K
-
M
PGV
N
L
TGN
S
AS
G
TR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
V
P
VTSRNS
VR
YS
WR
G
E
R
D
TR
G
----
D
T
NWV
PP
-
EQ
V
ERIEV
I
RGP
A
A
A
R
YG
S
G
A
A
GGVVNIITK
R
P
T
--------------
ND
W
HG
S
LS
L
YT
N
QP
E
SS
E
E
---
G
----
AT
R
RA
NF
SLS
GPL
A
G
D
ALTT
R
LY
G
NLN
K
TD
A
D
S
WDIN
SPV
GTKNA------
-
-
-
-AGH
E
GVR
N
K
D
I
N
G
VI
--
S
WK
L
NPQQ
I
L
DF
E
AGY
SRQ
GN
I
YA
GDT
Q
NS
S
S
S
A
V
TE
SL
AKS
-----------------
G
K
E
T
N
R
L
YR
QNYGITHNGIWDW
G
-
QSRFGIY
Y
EK
T
N
---------
N
---------
-
T
R
---
MNE
GL
S
G
GGE
G
RI
--
L
A
G
EK
F
T
TNRL
S
SWRTS
G
EL
NI
P
L
NVMVDQ
T
L
T
V
G
A
EW
NRD
K
LD
D
PSSTSLT
V
NDRDIS
G
-
I
S
G
-SAADRSSKNHS
Q
IS
A
L
---
-
--
Y
I
E
DNIE
P
VP
G
T
N
I
I
P
G
L
R
F
--------
D
Y
------------
LSDS
G
G
----------
N
F
SP
SLN
L
SQE
L
G
D
Y
F
K
V
K
A
G
VA
R
T
F
KAP
N
L
Y
Q
SSEG
Y
L
L
YSKGN
G
CPK
DI
TS
G
GCY
L
-----
I
GN
K
DL
D
PE
I
S
V
N
K
EIG
LEF-TWE
D
Y
H
A
S
VT
Y
F
R
N
D
YQ
NKIV
A
G
DNVI
GQ
T
A
SGAYILK
W
Q
N
G
GKA
L
VD
G
I
E
A
S
MSF
P
L
VKD
R
LNWNT
N
A
TW
M
-------
IT
SEQ
KD
---
T
G
N
----
P
LS
V
IP
K
Y
T
I
N
N
S
L
N
W
TIT
Q
AFSANVNW
T
LY
G
R
QK
P
RTH
AET
RSED
TG
-----
G
LS
G
KELGA
Y
S
LVG
T
NFN
YD
I
N
K
---
N
L
R
L
NVG
V
S
N
I
LN
K
-
-
---Q
I
FRS
S
E
---
----
--
-----
-
-
G
A
---
N
T
Y
NE
PGR
A
Y
Y
A
G
V
T
AS
F
fig|749550.3.peg.163
Escherichia coli MS 200-1 (35-725/725)
LVV
EATAEQV
L
KQ
Q
P
G
VSVI
TS
E
D
I
K
K
T
-
PPVN
DLS
D
I
I
R
K
-
M
PGV
N
L
TGN
S
AS
G
TR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
V
P
VTSRNS
VR
YS
WR
G
E
R
D
TR
G
----
D
T
NWV
PP
-
EQ
V
ERIEV
I
RGP
A
A
A
R
YG
S
G
A
A
GGVVNIITK
R
P
T
--------------
ND
W
HG
S
LS
L
YT
N
QP
E
SS
E
E
---
G
----
AT
R
RA
NF
SLS
GPL
A
G
D
ALTT
R
LY
G
NLN
K
TD
A
D
S
WDIN
SPV
GTKNA------
-
-
-
-AGH
E
GVR
N
K
D
I
N
G
VI
--
S
WK
L
NPQQ
I
L
DF
E
AGY
SRQ
GN
I
YA
GDT
Q
NS
S
S
S
A
V
TE
SL
AKS
-----------------
G
K
E
T
N
R
L
YR
QNYGITHNGIWDW
G
-
QSRFGIY
Y
EK
T
N
---------
N
---------
-
T
R
---
MNE
GL
S
G
GGE
G
RI
--
L
A
G
EK
F
T
TNRL
S
SWRTS
G
EL
NI
P
L
NVMVDQ
T
L
T
V
G
A
EW
NRD
K
LD
D
PSSTSLT
V
NDRDIS
G
-
I
S
G
-SAADRSSKNHS
Q
IS
A
L
---
-
--
Y
I
E
DNIE
P
VP
G
T
N
I
I
P
G
L
R
F
--------
D
Y
------------
LSDS
G
G
----------
N
F
SP
SLN
L
SQE
L
G
D
Y
F
K
V
K
A
G
VA
R
T
F
KAP
N
L
Y
Q
SSEG
Y
L
L
YSKGN
G
CPK
DI
TS
G
GCY
L
-----
I
GN
K
DL
D
PE
I
S
V
N
K
EIG
LEF-TWE
D
Y
H
A
S
VT
Y
F
R
N
D
YQ
NKIV
A
G
DNVI
GQ
T
A
SGAYILK
W
Q
N
G
GKA
L
VD
G
I
E
A
S
MSF
P
L
VKD
R
LNWNT
N
A
TW
M
-------
IT
SEQ
KD
---
T
G
N
----
P
LS
V
IP
K
Y
T
I
N
N
S
L
N
W
TIT
Q
AFSANVNW
T
LY
G
R
QK
P
RTH
AET
RSED
TG
-----
G
LS
G
KELGA
Y
S
LVG
T
NFN
YD
I
N
K
---
N
L
R
L
NVG
V
S
N
I
LN
K
-
-
---Q
I
FRS
S
E
---
----
--
-----
-
-
G
A
---
N
T
Y
NE
PGR
A
Y
Y
A
G
V
T
AS
F
fig|714962.3.peg.1126
Escherichia coli IHE3034 (35-725/725)
LVV
EATAEQV
L
KQ
Q
P
G
VSVI
TS
E
D
I
K
K
T
-
PPVN
DLS
D
I
I
R
K
-
M
PGV
N
L
TGN
S
AS
G
TR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
V
P
VTSRNS
VR
YS
WR
G
E
R
D
TR
G
----
D
T
NWV
PP
-
EQ
V
ERIEV
I
RGP
A
A
A
R
YG
S
G
A
A
GGVVNIITK
R
P
T
--------------
ND
W
HG
S
LS
L
YT
N
QP
E
SS
E
E
---
G
----
AT
R
RA
NF
SLS
GPL
A
G
D
ALTT
R
LY
G
NLN
K
TD
A
D
S
WDIN
SPV
GTKNA------
-
-
-
-AGH
E
GVR
N
K
D
I
N
G
VI
--
S
WK
L
NPQQ
I
L
DF
E
AGY
SRQ
GN
I
YA
GDT
Q
NS
S
S
S
A
V
TE
SL
AKS
-----------------
G
K
E
T
N
R
L
YR
QNYGITHNGIWDW
G
-
QSRFGVY
Y
EK
T
N
---------
N
---------
-
T
R
---
MNE
GL
S
G
GGE
G
RI
--
L
A
G
EK
F
T
TNRL
S
SWRTS
G
EL
NI
P
L
NVMVDQ
T
L
T
V
G
A
EW
NRD
K
LD
D
PSSTSLT
V
NDRDIS
G
-
I
S
G
-SAADRSSKNHS
Q
IS
A
L
---
-
--
Y
I
E
DNIE
P
VP
G
T
N
I
I
P
G
L
R
F
--------
D
Y
------------
LSDS
G
G
----------
N
F
SP
SLN
L
SQE
L
G
D
Y
F
K
V
K
A
G
VA
R
T
F
KAP
N
L
Y
Q
SSEG
Y
L
L
YSKGN
G
CPK
DI
TS
G
GCY
L
-----
I
GN
K
DL
D
PE
I
S
V
N
K
EIG
LEF-TWE
D
Y
H
A
S
VT
Y
F
R
N
D
YQ
NKIV
A
G
DNVI
GQ
T
A
SGAYILK
W
Q
N
G
GKA
L
VD
G
I
E
A
S
MSF
P
L
VKD
R
LNWNT
N
A
TW
M
-------
IT
SEQ
KD
---
T
G
N
----
P
LS
V
IP
K
Y
T
I
N
N
S
L
N
W
TIT
Q
AFSASVNW
T
LY
G
R
QK
P
RTH
AET
RSED
TG
-----
G
LS
G
KELGA
Y
S
LVG
T
NFN
YD
I
N
K
---
N
L
R
L
NVG
V
S
N
I
LN
K
-
-
---Q
I
FRS
S
E
---
----
--
-----
-
-
G
A
---
N
T
Y
NE
PGR
A
Y
Y
A
G
V
T
AS
F
fig|753642.3.peg.546
Escherichia coli NC101 (35-725/725)
LVV
EATAEQV
L
KQ
Q
P
G
VSVI
TS
E
D
I
K
K
T
-
PPVN
DLS
D
I
I
R
K
-
M
PGV
N
L
TGN
S
AS
G
TR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
V
P
VTSRNS
VR
YS
WR
G
E
R
D
TR
G
----
D
T
NWV
PP
-
EQ
V
ERIEV
I
RGP
A
A
A
R
YG
S
G
A
A
GGVVNIITK
R
P
T
--------------
ND
W
HG
S
LS
L
YT
N
QP
E
SS
E
E
---
G
----
AT
R
RA
NF
SLS
GPL
A
G
D
ALTT
R
LY
G
NLN
K
TD
A
D
S
WDIN
SPV
GTKNA------
-
-
-
-AGH
E
GVR
N
K
D
I
N
G
VI
--
S
WK
L
NPQQ
I
L
DF
E
AGY
SRQ
GN
I
YA
GDT
Q
NS
S
S
S
A
V
TE
SL
AKS
-----------------
G
K
E
T
N
R
L
YR
QNYGITHNGIWDW
G
-
QSRFGVY
Y
EK
T
N
---------
N
---------
-
T
R
---
MNE
GL
S
G
GGE
G
RI
--
L
A
G
EK
F
T
TNRL
S
SWRTS
G
EL
NI
P
L
NVMVDQ
T
L
T
V
G
A
EW
NRD
K
LD
D
PSSTSLT
V
NDRDIS
G
-
I
S
G
-SAADRSSKNHS
Q
IS
A
L
---
-
--
Y
I
E
DNIE
P
VP
G
T
N
I
I
P
G
L
R
F
--------
D
Y
------------
LSDS
G
G
----------
N
F
SP
SLN
L
SQE
L
G
D
Y
F
K
V
K
A
G
VA
R
T
F
KAP
N
L
Y
Q
SSEG
Y
L
L
YSKGN
G
CPK
DI
TS
G
GCY
L
-----
I
GN
K
DL
D
PE
I
S
V
N
K
EIG
LEF-TWE
D
Y
H
A
S
VT
Y
F
R
N
D
YQ
NKIV
A
G
DNVI
GQ
T
A
SGAYILK
W
Q
N
G
GKA
L
VD
G
I
E
A
S
MSF
P
L
VKD
R
LNWNT
N
A
TW
M
-------
IT
SEQ
KD
---
T
G
N
----
P
LS
V
IP
K
Y
T
I
N
N
S
L
N
W
TIT
Q
AFSASVNW
T
LY
G
R
QK
P
RTH
AET
RSED
TG
-----
G
LS
G
KELGA
Y
S
LVG
T
NFN
YD
I
N
K
---
N
L
R
L
NVG
V
S
N
I
LN
K
-
-
---Q
I
FRS
S
E
---
----
--
-----
-
-
G
A
---
N
T
Y
NE
PGR
A
Y
Y
A
G
V
T
AS
F
fig|585035.6.peg.5092
Escherichia coli S88 (35-720/720)
LVV
EATAEQV
L
KQ
Q
P
G
VSVI
TS
E
D
I
K
K
T
-
PPVN
DLS
D
I
I
R
K
-
M
PGV
N
L
TGN
S
AS
G
TR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
V
P
VTSRNS
VR
YS
WR
G
E
R
D
TR
G
----
D
T
NWV
PP
-
EQ
V
ERIEV
I
RGP
A
A
A
R
YG
S
G
A
A
GGVVNIITK
R
P
T
--------------
ND
W
HG
S
LS
L
YT
N
QP
E
SS
D
E
---
G
----
AT
R
RA
NF
SLS
GPL
A
G
N
ALTT
R
LY
G
NLN
K
TD
A
D
S
WDIN
SPV
GTKNA------
-
-
-
-AGH
E
GVR
N
K
D
I
N
G
VV
--
S
WK
L
NPQQ
I
L
DF
E
AGY
SRQ
GN
I
YA
GDT
Q
NS
S
S
S
A
V
TE
SL
AKS
-----------------
G
K
E
T
N
R
L
YR
QNYGITHNGIWDW
G
-
QSRFGVY
Y
EK
T
N
---------
N
---------
-
T
R
---
MNE
GL
S
G
GGE
G
RI
--
L
A
G
EK
F
T
TNRL
S
SWRTS
G
EL
NI
P
L
NVMVDQ
T
L
T
V
G
A
EW
NRD
K
LD
D
PSSTSLT
V
NDSDIS
G
-
I
S
G
-SAADRSSKNHS
Q
IS
A
L
---
-
--
Y
I
E
DNIE
P
VP
G
T
N
I
I
P
G
L
R
F
--------
D
Y
------------
LSDS
G
G
----------
N
F
SP
SLN
L
SQE
L
G
D
Y
F
K
V
K
A
G
VA
R
T
F
KAP
N
L
Y
Q
SSEG
Y
L
L
YSKGN
G
CP-
--
--
G
GCY
L
-----
I
GN
K
DL
D
PE
I
S
V
N
K
EIG
LEF-TWE
D
Y
H
A
S
VT
Y
F
R
N
D
YQ
NKIV
A
G
DNVI
GQ
T
A
SGAYILK
W
Q
N
G
GKA
L
VD
G
I
E
A
S
MSF
P
L
VKD
R
LNWNT
N
A
TW
M
-------
IT
SEQ
KD
---
T
G
N
----
P
LS
V
IP
K
Y
T
I
N
N
S
L
N
W
TIT
Q
AFSASVNW
T
LY
G
R
QK
P
RTH
AET
RSED
TG
-----
G
LS
G
KELGA
Y
S
LVG
T
NFN
YD
I
N
K
---
N
L
R
L
NVG
V
S
N
I
LN
K
-
-
---Q
I
FRS
S
E
---
----
--
-----
-
-
G
A
---
N
T
Y
NE
PGR
A
Y
Y
A
G
V
T
AS
F
fig|679205.4.peg.4865
Escherichia coli MS 124-1 (35-722/722)
LVV
EATAEQV
L
KQ
Q
P
G
VSVI
TS
E
D
I
K
K
T
-
PPVN
DLS
D
I
I
R
K
-
M
PGV
N
L
TGN
S
AS
G
TR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
V
P
VTSRNS
VR
YS
WR
G
E
R
D
TR
G
----
D
T
NWV
PP
-
EQ
V
ERIEV
I
RGP
A
A
A
R
YG
S
G
A
A
GGVVNIITK
R
P
T
--------------
ND
W
HG
S
LS
L
YT
N
QP
E
SS
D
E
---
G
----
AT
R
RA
NF
SLS
GPL
A
G
N
ALTT
R
LY
G
NLN
K
TD
A
D
S
WDIN
SPV
GTKNA------
-
-
-
-AGH
E
GVR
N
K
D
I
N
G
VV
--
S
WK
L
NPQQ
I
L
DF
E
AGY
SRQ
GN
I
YA
GDT
Q
NS
S
S
S
A
V
TE
SL
AKS
-----------------
G
K
E
T
N
R
L
YR
QNYGITHNGIWDW
G
-
QSRFGVY
Y
EK
T
N
---------
N
---------
-
T
R
---
MNE
GL
S
G
GGE
G
RI
--
L
A
G
EK
F
T
TNRL
S
SWRTS
G
EL
NI
P
L
NVMVDQ
T
L
T
V
G
A
EW
NRD
K
LD
D
PSSTSLT
V
NDSD--
-
-
I
S
G
-SAADRSSKNHS
Q
IS
A
L
---
-
--
Y
I
E
DNIE
P
VP
G
T
N
I
I
P
G
V
R
F
--------
D
Y
------------
LSDS
G
G
----------
N
F
SP
SLN
L
SQE
L
G
D
Y
F
K
V
K
A
G
VA
R
T
F
KAP
N
L
Y
Q
SSEG
Y
L
L
YSKGN
G
CPK
DI
TS
G
GCY
L
-----
I
GN
K
DL
D
PE
I
S
V
N
K
EIG
LEF-TWE
D
Y
H
A
S
VT
Y
F
R
N
D
YQ
NKIV
A
G
DNVI
GQ
T
A
SGAYILK
W
Q
N
G
GKA
L
VD
G
I
E
A
S
MSF
P
L
VKD
R
LNWNT
N
A
TW
M
-------
IT
SEQ
KD
---
T
G
N
----
P
LS
V
IP
K
Y
T
I
N
N
S
L
N
W
TIT
Q
AFSASVNW
T
LY
G
R
QK
P
RTH
AET
RSED
TG
-----
G
LS
G
KELGA
Y
S
LVG
T
NFN
YD
I
N
K
---
N
L
R
L
NVG
V
S
N
I
LN
K
-
-
---Q
I
FRS
S
E
---
----
--
-----
-
-
G
A
---
N
T
Y
NE
PGR
A
Y
Y
A
G
V
T
AS
F
fig|749533.3.peg.3468
Escherichia coli MS 84-1 (35-722/722)
LVV
EATAEQV
L
KQ
Q
P
G
VSVI
TS
E
D
I
K
K
T
-
PPVN
DLS
D
I
I
R
K
-
M
PGV
N
L
TGN
S
AS
G
TR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
V
P
VTSRNS
VR
YS
WR
G
E
R
D
TR
G
----
D
T
NWV
PP
-
EQ
V
ERIEV
I
RGP
A
A
A
R
YG
S
G
A
A
GGVVNIITK
R
P
T
--------------
ND
W
HG
S
LS
L
YT
N
QP
E
SS
D
E
---
G
----
AT
R
RA
NF
SLS
GPL
A
G
N
ALTT
R
LY
G
NLN
K
TD
A
D
S
WDIN
SPV
GTKNA------
-
-
-
-AGH
E
GVR
N
K
D
I
N
G
VV
--
S
WK
L
NPQQ
I
L
DF
E
AGY
SRQ
GN
I
YA
GDT
Q
NS
S
S
S
A
V
TE
SL
AKS
-----------------
G
K
E
T
N
R
L
YR
QNYGITHNGIWDW
G
-
QSRFGVY
Y
EK
T
N
---------
N
---------
-
T
R
---
MNE
GL
S
G
GGE
G
RI
--
L
A
G
EK
F
T
TNRL
S
SWRTS
G
EL
NI
P
L
NVMVDQ
T
L
T
V
G
A
EW
NRD
K
LD
D
PSSTSLT
V
NDSD--
-
-
I
S
G
-SAADRSSKNHS
Q
IS
A
L
---
-
--
Y
I
E
DNIE
P
VP
G
T
N
I
I
P
G
V
R
F
--------
D
Y
------------
LSDS
G
G
----------
N
F
SP
SLN
L
SQE
L
G
D
Y
F
K
V
K
A
G
VA
R
T
F
KAP
N
L
Y
Q
SSEG
Y
L
L
YSKGN
G
CPK
DI
TS
G
GCY
L
-----
I
GN
K
DL
D
PE
I
S
V
N
K
EIG
LEF-TWE
D
Y
H
A
S
VT
Y
F
R
N
D
YQ
NKIV
A
G
DNVI
GQ
T
A
SGAYILK
W
Q
N
G
GKA
L
VD
G
I
E
A
S
MSF
P
L
VKD
R
LNWNT
N
A
TW
M
-------
IT
SEQ
KD
---
T
G
N
----
P
LS
V
IP
K
Y
T
I
N
N
S
L
N
W
TIT
Q
AFSASVNW
T
LY
G
R
QK
P
RTH
AET
RSED
TG
-----
G
LS
G
KELGA
Y
S
LVG
T
NFN
YD
I
N
K
---
N
L
R
L
NVG
V
S
N
I
LN
K
-
-
---Q
I
FRS
S
E
---
----
--
-----
-
-
G
A
---
N
T
Y
NE
PGR
A
Y
Y
A
G
V
T
AS
F
fig|656393.3.peg.5417
Escherichia coli H299 (35-725/725)
LVV
EATAEQI
L
KQ
Q
P
G
VSVI
TS
E
D
I
K
K
S
-
PPVN
D
I
S
D
I
I
R
K
-
M
PGV
N
L
TGN
S
AS
G
TR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
V
P
VTSRNS
VR
YS
WR
G
E
R
D
TR
G
----
D
T
NWV
PP
-
EQ
V
ERIEV
I
RGP
A
A
A
R
YG
S
G
A
A
GGVVNIITK
R
P
T
--------------
ND
W
HA
S
LS
L
YT
N
QP
E
SS
D
E
---
G
----
AT
R
RA
NF
SLS
GP
M
A
G
N
ALTT
R
LY
G
NLN
K
TD
A
D
S
WDIN
SPV
GTKNA------
-
-
-
-AGH
E
GVR
N
K
D
I
N
G
VV
--
S
WK
L
NPQQ
I
L
DF
E
AGY
SRQ
GN
I
YA
GDT
Q
NS
S
S
S
A
V
TE
SL
AKS
-----------------
G
K
E
T
N
R
L
YR
QNYGITHNGIWDW
G
-
QSRFGVY
Y
EK
T
N
---------
N
---------
-
T
R
---
MNE
GL
S
G
GGE
G
RI
--
L
A
G
EK
F
T
TNRL
S
SWRTS
G
EL
NI
P
L
NVMVDQ
T
L
T
V
G
A
EW
NRD
K
LD
D
PSSTSLT
V
NDRDIS
G
-
I
S
G
-SAADRSSKNHS
Q
IS
A
L
---
-
--
Y
I
E
DNIE
P
VP
G
T
N
I
I
P
G
L
R
F
--------
D
Y
------------
LSDS
G
G
----------
N
F
SP
SLN
L
SQE
L
G
D
Y
F
K
V
K
A
G
VA
R
T
F
KAP
N
L
Y
Q
SSEG
Y
L
L
YSKGN
G
CPK
DI
TS
G
GCY
L
-----
I
GN
K
DL
D
PE
I
S
V
N
K
EIG
LEF-TWE
D
Y
H
A
S
VT
Y
F
R
N
D
YQ
NKIV
A
G
DNVI
GQ
T
A
SGAYILK
W
Q
N
G
GKA
L
VD
G
I
E
A
S
MSF
P
L
VKD
R
LNWNT
N
A
TW
M
-------
IT
SEQ
KD
---
T
G
N
----
P
LS
V
IP
K
Y
T
I
N
N
S
L
N
W
TIT
Q
AFSASVNW
T
LY
G
R
QK
P
RTH
AET
RSED
TG
-----
G
LS
G
KELGA
Y
S
LVG
T
NFN
YD
I
N
K
---
N
L
R
L
NVG
V
S
N
I
LN
K
-
-
---Q
I
FRS
S
E
---
----
--
-----
-
-
G
A
---
N
T
Y
NE
PGR
A
Y
Y
A
G
V
T
AS
F
fig|405955.13.peg.5148
Escherichia coli APEC O1 (35-725/725)
LVV
EATAEQV
L
KQ
Q
P
G
VSVI
TS
E
D
I
K
K
T
-
PPVN
DLS
D
I
I
R
K
-
M
PGV
N
L
TGN
S
AS
G
TR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
V
P
VTSRNS
VR
YS
WR
G
E
R
D
TR
G
----
D
T
NWV
PP
-
EQ
V
ERIEV
I
RGP
A
A
A
R
YG
S
G
A
A
GGVVNIITK
R
P
T
--------------
ND
W
HG
S
LS
L
YT
N
QP
E
SS
D
E
---
G
----
AT
R
RA
NF
SLS
GPL
A
G
N
ALTT
R
LY
G
NLN
K
TD
A
D
S
WDIN
SPV
GTKNA------
-
-
-
-AGH
E
GVR
N
K
D
I
N
G
VV
--
S
WK
L
NPQQ
I
L
DF
E
AGY
SRQ
GN
I
YA
GDT
Q
NS
S
S
S
A
V
TE
SL
AKS
-----------------
G
K
E
T
N
R
L
YR
QNYGITHNGIWDW
G
-
QSRFGVY
Y
EK
T
N
---------
N
---------
-
T
R
---
MNE
GL
S
G
GGE
G
RI
--
L
A
G
EK
F
T
TNRL
S
SWRTS
G
EL
NI
P
L
NVMVDQ
T
L
T
V
G
A
EW
NRD
K
LD
D
PSSTSLT
V
NDSDIS
G
-
I
S
G
-SAADRSSKNHS
Q
IS
A
L
---
-
--
Y
I
E
DNIE
P
VP
G
T
N
I
I
P
G
L
R
F
--------
D
Y
------------
LSDS
G
G
----------
N
F
SP
SLN
L
SQE
L
G
D
Y
F
K
V
K
A
G
VA
R
T
F
KAP
N
L
Y
Q
SSEG
Y
L
L
YSKGN
G
CPK
DI
TS
G
GCY
L
-----
I
GN
K
DL
D
PE
I
S
V
N
K
EIG
LEF-TWE
D
Y
H
A
S
VT
Y
F
R
N
D
YQ
NKIV
A
G
DNVI
GQ
T
A
SGAYILK
W
Q
N
G
GKA
L
VD
G
I
E
A
S
MSF
P
L
VKD
R
LNWNT
N
A
TW
M
-------
IT
SEQ
KD
---
T
G
N
----
P
LS
V
IP
K
Y
T
I
N
N
S
L
N
W
TIT
Q
AFSASVNW
T
LY
G
R
QK
P
RTH
AET
RSED
TG
-----
G
LS
G
KELGA
Y
S
LVG
T
NFN
YD
I
N
K
---
N
L
R
L
NVG
V
S
N
I
LN
K
-
-
---Q
I
FRS
S
E
---
----
--
-----
-
-
G
A
---
N
T
Y
NE
PGR
A
Y
Y
A
G
V
T
AS
F
fig|405955.9.peg.4312
Escherichia coli APEC O1 (35-725/725)
LVV
EATAEQV
L
KQ
Q
P
G
VSVI
TS
E
D
I
K
K
T
-
PPVN
DLS
D
I
I
R
K
-
M
PGV
N
L
TGN
S
AS
G
TR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
V
P
VTSRNS
VR
YS
WR
G
E
R
D
TR
G
----
D
T
NWV
PP
-
EQ
V
ERIEV
I
RGP
A
A
A
R
YG
S
G
A
A
GGVVNIITK
R
P
T
--------------
ND
W
HG
S
LS
L
YT
N
QP
E
SS
D
E
---
G
----
AT
R
RA
NF
SLS
GPL
A
G
N
ALTT
R
LY
G
NLN
K
TD
A
D
S
WDIN
SPV
GTKNA------
-
-
-
-AGH
E
GVR
N
K
D
I
N
G
VV
--
S
WK
L
NPQQ
I
L
DF
E
AGY
SRQ
GN
I
YA
GDT
Q
NS
S
S
S
A
V
TE
SL
AKS
-----------------
G
K
E
T
N
R
L
YR
QNYGITHNGIWDW
G
-
QSRFGVY
Y
EK
T
N
---------
N
---------
-
T
R
---
MNE
GL
S
G
GGE
G
RI
--
L
A
G
EK
F
T
TNRL
S
SWRTS
G
EL
NI
P
L
NVMVDQ
T
L
T
V
G
A
EW
NRD
K
LD
D
PSSTSLT
V
NDSDIS
G
-
I
S
G
-SAADRSSKNHS
Q
IS
A
L
---
-
--
Y
I
E
DNIE
P
VP
G
T
N
I
I
P
G
L
R
F
--------
D
Y
------------
LSDS
G
G
----------
N
F
SP
SLN
L
SQE
L
G
D
Y
F
K
V
K
A
G
VA
R
T
F
KAP
N
L
Y
Q
SSEG
Y
L
L
YSKGN
G
CPK
DI
TS
G
GCY
L
-----
I
GN
K
DL
D
PE
I
S
V
N
K
EIG
LEF-TWE
D
Y
H
A
S
VT
Y
F
R
N
D
YQ
NKIV
A
G
DNVI
GQ
T
A
SGAYILK
W
Q
N
G
GKA
L
VD
G
I
E
A
S
MSF
P
L
VKD
R
LNWNT
N
A
TW
M
-------
IT
SEQ
KD
---
T
G
N
----
P
LS
V
IP
K
Y
T
I
N
N
S
L
N
W
TIT
Q
AFSASVNW
T
LY
G
R
QK
P
RTH
AET
RSED
TG
-----
G
LS
G
KELGA
Y
S
LVG
T
NFN
YD
I
N
K
---
N
L
R
L
NVG
V
S
N
I
LN
K
-
-
---Q
I
FRS
S
E
---
----
--
-----
-
-
G
A
---
N
T
Y
NE
PGR
A
Y
Y
A
G
V
T
AS
F
fig|656419.3.peg.1821
Escherichia coli M718 (35-725/725)
LVV
EATAEQV
L
KQ
Q
P
G
VSVI
TS
E
D
I
K
K
T
-
PPVN
DLS
D
I
I
R
K
-
M
PGV
N
L
TGN
S
AS
G
TR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
V
P
VTSRNS
VR
YS
WR
G
E
R
D
TR
G
----
D
T
NWV
PP
-
EQ
V
ERIEV
I
RGP
A
A
A
R
YG
S
G
A
A
GGVVNIITK
R
P
T
--------------
ND
W
HG
S
LS
L
YT
N
QP
E
SS
D
E
---
G
----
AT
R
RA
NF
SLS
GPL
A
G
N
ALTT
R
LY
G
NLN
K
TD
A
D
S
WDIN
SPV
GTKNA------
-
-
-
-AGH
E
GVR
N
K
D
I
N
G
VV
--
S
WK
L
NPQQ
I
L
DF
E
AGY
SRQ
GN
I
YA
GDT
Q
NS
S
S
S
A
V
TE
SL
AKS
-----------------
G
K
E
T
N
R
L
YR
QNYGITHNGIWDW
G
-
QSRFGVY
Y
EK
T
N
---------
N
---------
-
T
R
---
MNE
GL
S
G
GGE
G
RI
--
L
A
G
EK
F
T
TNRL
S
SWRTS
G
EL
NI
P
L
NVMVDQ
T
L
T
V
G
A
EW
NRD
K
LD
D
PSSTSLT
V
NDSDIS
G
-
I
S
G
-SAADRSSKNHS
Q
IS
A
L
---
-
--
Y
I
E
DNIE
P
VP
G
T
N
I
I
P
G
L
R
F
--------
D
Y
------------
LSDS
G
G
----------
N
F
SP
SLN
L
SQE
L
G
D
Y
F
K
V
K
A
G
VA
R
T
F
KAP
N
L
Y
Q
SSEG
Y
L
L
YSKGN
G
CPK
DI
TS
G
GCY
L
-----
I
GN
K
DL
D
PE
I
S
V
N
K
EIG
LEF-TWE
D
Y
H
A
S
VT
Y
F
R
N
D
YQ
NKIV
A
G
DNVI
GQ
T
A
SGAYILK
W
Q
N
G
GKA
L
VD
G
I
E
A
S
MSF
P
L
VKD
R
LNWNT
N
A
TW
M
-------
IT
SEQ
KD
---
T
G
N
----
P
LS
V
IP
K
Y
T
I
N
N
S
L
N
W
TIT
Q
AFSASVNW
T
LY
G
R
QK
P
RTH
AET
RSED
TG
-----
G
LS
G
KELGA
Y
S
LVG
T
NFN
YD
I
N
K
---
N
L
R
L
NVG
V
S
N
I
LN
K
-
-
---Q
I
FRS
S
E
---
----
--
-----
-
-
G
A
---
N
T
Y
NE
PGR
A
Y
Y
A
G
V
T
AS
F
fig|685038.3.peg.4554
Escherichia coli O83:H1 str. NRG 857C (35-725/725)
LVV
EATAEQV
L
KQ
Q
P
G
VSVI
TS
E
D
I
K
K
T
-
PPVN
DLS
D
I
I
R
K
-
M
PGV
N
L
TGN
S
AS
G
TR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
V
P
VTSRNS
VR
YS
WR
G
E
R
D
TR
G
----
D
T
NWV
PP
-
EQ
V
ERIEV
I
RGP
A
A
A
R
YG
S
G
A
A
GGVVNIITK
R
P
T
--------------
ND
W
HG
S
LS
L
YT
N
QP
E
SS
D
E
---
G
----
AT
R
RA
NF
SLS
GPL
A
G
N
ALTT
R
LY
G
NLN
K
TD
A
D
S
WDIN
SPV
GTKNA------
-
-
-
-AGH
E
GVR
N
K
D
I
N
G
VV
--
S
WK
L
NPQQ
I
L
DF
E
AGY
SRQ
GN
I
YA
GDT
Q
NS
S
S
S
A
V
TE
SL
AKS
-----------------
G
K
E
T
N
R
L
YR
QNYGITHNGIWDW
G
-
QSRFGVY
Y
EK
T
N
---------
N
---------
-
T
R
---
MNE
GL
S
G
GGE
G
RI
--
L
A
G
EK
F
T
TNRL
S
SWRTS
G
EL
NI
P
L
NVMVDQ
T
L
T
V
G
A
EW
NRD
K
LD
D
PSSTSLT
V
NDSDIS
G
-
I
S
G
-SAADRSSKNHS
Q
IS
A
L
---
-
--
Y
I
E
DNIE
P
VP
G
T
N
I
I
P
G
L
R
F
--------
D
Y
------------
LSDS
G
G
----------
N
F
SP
SLN
L
SQE
L
G
D
Y
F
K
V
K
A
G
VA
R
T
F
KAP
N
L
Y
Q
SSEG
Y
L
L
YSKGN
G
CPK
DI
TS
G
GCY
L
-----
I
GN
K
DL
D
PE
I
S
V
N
K
EIG
LEF-TWE
D
Y
H
A
S
VT
Y
F
R
N
D
YQ
NKIV
A
G
DNVI
GQ
T
A
SGAYILK
W
Q
N
G
GKA
L
VD
G
I
E
A
S
MSF
P
L
VKD
R
LNWNT
N
A
TW
M
-------
IT
SEQ
KD
---
T
G
N
----
P
LS
V
IP
K
Y
T
I
N
N
S
L
N
W
TIT
Q
AFSASVNW
T
LY
G
R
QK
P
RTH
AET
RSED
TG
-----
G
LS
G
KELGA
Y
S
LVG
T
NFN
YD
I
N
K
---
N
L
R
L
NVG
V
S
N
I
LN
K
-
-
---Q
I
FRS
S
E
---
----
--
-----
-
-
G
A
---
N
T
Y
NE
PGR
A
Y
Y
A
G
V
T
AS
F
fig|869729.3.peg.2625
Escherichia coli UM146 (35-725/725)
LVV
EATAEQV
L
KQ
Q
P
G
VSVI
TS
E
D
I
K
K
T
-
PPVN
DLS
D
I
I
R
K
-
M
PGV
N
L
TGN
S
AS
G
TR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
V
P
VTSRNS
VR
YS
WR
G
E
R
D
TR
G
----
D
T
NWV
PP
-
EQ
V
ERIEV
I
RGP
A
A
A
R
YG
S
G
A
A
GGVVNIITK
R
P
T
--------------
ND
W
HG
S
LS
L
YT
N
QP
E
SS
D
E
---
G
----
AT
R
RA
NF
SLS
GPL
A
G
N
ALTT
R
LY
G
NLN
K
TD
A
D
S
WDIN
SPV
GTKNA------
-
-
-
-AGH
E
GVR
N
K
D
I
N
G
VV
--
S
WK
L
NPQQ
I
L
DF
E
AGY
SRQ
GN
I
YA
GDT
Q
NS
S
S
S
A
V
TE
SL
AKS
-----------------
G
K
E
T
N
R
L
YR
QNYGITHNGIWDW
G
-
QSRFGVY
Y
EK
T
N
---------
N
---------
-
T
R
---
MNE
GL
S
G
GGE
G
RI
--
L
A
G
EK
F
T
TNRL
S
SWRTS
G
EL
NI
P
L
NVMVDQ
T
L
T
V
G
A
EW
NRD
K
LD
D
PSSTSLT
V
NDSDIS
G
-
I
S
G
-SAADRSSKNHS
Q
IS
A
L
---
-
--
Y
I
E
DNIE
P
VP
G
T
N
I
I
P
G
L
R
F
--------
D
Y
------------
LSDS
G
G
----------
N
F
SP
SLN
L
SQE
L
G
D
Y
F
K
V
K
A
G
VA
R
T
F
KAP
N
L
Y
Q
SSEG
Y
L
L
YSKGN
G
CPK
DI
TS
G
GCY
L
-----
I
GN
K
DL
D
PE
I
S
V
N
K
EIG
LEF-TWE
D
Y
H
A
S
VT
Y
F
R
N
D
YQ
NKIV
A
G
DNVI
GQ
T
A
SGAYILK
W
Q
N
G
GKA
L
VD
G
I
E
A
S
MSF
P
L
VKD
R
LNWNT
N
A
TW
M
-------
IT
SEQ
KD
---
T
G
N
----
P
LS
V
IP
K
Y
T
I
N
N
S
L
N
W
TIT
Q
AFSASVNW
T
LY
G
R
QK
P
RTH
AET
RSED
TG
-----
G
LS
G
KELGA
Y
S
LVG
T
NFN
YD
I
N
K
---
N
L
R
L
NVG
V
S
N
I
LN
K
-
-
---Q
I
FRS
S
E
---
----
--
-----
-
-
G
A
---
N
T
Y
NE
PGR
A
Y
Y
A
G
V
T
AS
F
fig|364106.7.peg.1199
Escherichia coli UTI89 (35-725/725)
LVV
EATAEQV
L
KQ
Q
P
G
VSVI
TS
E
D
I
K
K
T
-
PPVN
DLS
D
I
I
R
K
-
M
PGV
N
L
TGN
S
AS
G
TR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
V
P
VTSRNS
VR
YS
WR
G
E
R
D
TR
G
----
D
T
NWV
PP
-
EQ
V
ERIEV
I
RGP
A
A
A
R
YG
S
G
A
A
GGVVNIITK
R
P
T
--------------
ND
W
HG
S
LS
L
YT
N
QP
E
SS
D
E
---
G
----
AT
R
RA
NF
SLS
GPL
A
G
N
ALTT
R
LY
G
NLN
K
TD
A
D
S
WDIN
SPV
GTKNA------
-
-
-
-AGH
E
GVR
N
K
D
I
N
G
VV
--
S
WK
L
NPQQ
I
L
DF
E
AGY
SRQ
GN
I
YA
GDT
Q
NS
S
S
S
A
V
TE
SL
AKS
-----------------
G
K
E
T
N
R
L
YR
QNYGITHNGIWDW
G
-
QSRFGVY
Y
EK
T
N
---------
N
---------
-
T
R
---
MNE
GL
S
G
GGE
G
RI
--
L
A
G
EK
F
T
TNRL
S
SWRTS
G
EL
NI
P
L
NVMVDQ
T
L
T
V
G
A
EW
NRD
K
LD
D
PSSTSLT
V
NDSDIS
G
-
I
S
G
-SAADRSSKNHS
Q
IS
A
L
---
-
--
Y
I
E
DNIE
P
VP
G
T
N
I
I
P
G
L
R
F
--------
D
Y
------------
LSDS
G
G
----------
N
F
SP
SLN
L
SQE
L
G
D
Y
F
K
V
K
A
G
VA
R
T
F
KAP
N
L
Y
Q
SSEG
Y
L
L
YSKGN
G
CPK
DI
TS
G
GCY
L
-----
I
GN
K
DL
D
PE
I
S
V
N
K
EIG
LEF-TWE
D
Y
H
A
S
VT
Y
F
R
N
D
YQ
NKIV
A
G
DNVI
GQ
T
A
SGAYILK
W
Q
N
G
GKA
L
VD
G
I
E
A
S
MSF
P
L
VKD
R
LNWNT
N
A
TW
M
-------
IT
SEQ
KD
---
T
G
N
----
P
LS
V
IP
K
Y
T
I
N
N
S
L
N
W
TIT
Q
AFSASVNW
T
LY
G
R
QK
P
RTH
AET
RSED
TG
-----
G
LS
G
KELGA
Y
S
LVG
T
NFN
YD
I
N
K
---
N
L
R
L
NVG
V
S
N
I
LN
K
-
-
---Q
I
FRS
S
E
---
----
--
-----
-
-
G
A
---
N
T
Y
NE
PGR
A
Y
Y
A
G
V
T
AS
F
fig|364106.8.peg.1197
Escherichia coli UTI89 (35-725/725)
LVV
EATAEQV
L
KQ
Q
P
G
VSVI
TS
E
D
I
K
K
T
-
PPVN
DLS
D
I
I
R
K
-
M
PGV
N
L
TGN
S
AS
G
TR
G
N
N
R
QI
D
IRGMG
PEN
TL
------
ILIDG
V
P
VTSRNS
VR
YS
WR
G
E
R
D
TR
G
----
D
T
NWV
PP
-
EQ
V
ERIEV
I
RGP
A
A
A
R
YG
S
G
A
A
GGVVNIITK
R
P
T
--------------
ND
W
HG
S
LS
L
YT
N
QP
E
SS
D
E
---
G
----
AT
R
RA
NF
SLS
GPL
A
G
N
ALTT
R
LY
G
NLN
K
TD
A
D
S
WDIN
SPV
GTKNA------
-
-
-
-AGH
E
GVR
N
K
D
I
N
G
VV
--
S
WK
L
NPQQ
I
L
DF
E
AGY
SRQ
GN
I
YA
GDT
Q
NS
S
S
S
A
V
TE
SL
AKS
-----------------
G
K
E
T
N
R
L
YR
QNYGITHNGIWDW
G
-
QSRFGVY
Y
EK
T
N
---------
N
---------
-
T
R
---
MNE
GL
S
G
GGE
G
RI
--
L
A
G
EK
F
T
TNRL
S
SWRTS
G
EL
NI
P
L
NVMVDQ
T
L
T
V
G
A
EW
NRD
K
LD
D
PSSTSLT
V
NDSDIS
G
-
I
S
G
-SAADRSSKNHS
Q
IS
A
L
---
-
--
Y
I
E
DNIE
P
VP
G
T
N
I
I
P
G
L
R
F
--------
D
Y
------------
LSDS
G
G
----------
N
F
SP
SLN
L
SQE
L
G
D
Y
F
K
V
K
A
G
VA
R
T
F
KAP
N
L
Y
Q
SSEG
Y
L
L
YSKGN
G
CPK
DI
TS
G
GCY
L
-----
I
GN
K
DL
D
PE
I
S
V
N
K
EIG
LEF-TWE
D
Y
H
A
S
VT
Y
F
R
N
D
YQ
NKIV
A
G
DNVI
GQ
T
A
SGAYILK
W
Q
N
G
GKA
L
VD
G
I
E
A
S
MSF
P
L
VKD
R
LNWNT
N
A
TW
M
-------
IT
SEQ
KD
---
T
G
N
----
P
LS
V
IP
K
Y
T
I
N
N
S
L
N
W
TIT
Q
AFSASVNW
T
LY
G
R
QK
P
RTH
AET
RSED
TG
-----
G
LS
G
KELGA
Y
S
LVG
T
NFN
YD
I
N
K
---
N
L
R
L
NVG
V
S
N
I
LN
K
-
-
---Q
I
FRS
S
E
---
----
--
-----
-
-
G
A
---
N
T
Y
NE
PGR
A
Y
Y
A
G
V
T
AS
F
fig|362663.8.peg.1466
Escherichia coli 536 (29-694/700)
MIVSA
APQVVSE
L
DT
P
A
A
VSV
V
DG
EE
M
R
L
A
-
TPRI
N
LSE
S
L
T
G
-
VPG
L
Q
V
QNR
Q
NY
A
Q-
-
-
D
LQ
L
SIRG
F
G
SRS
T
YGIRGIRLYV
DG
I
P
ATMPDG
--
QG
QT
S
N
I
D
L-
-
----
-
-
---
--
-
SS
VQNV
EVLRGP
F
SALYGN
-
A
S
GGV
M
N
VT
T
Q
T
G
Q
QPPTIEASSYYGSF
GS
W
RY
G
LK
A
TG
A
TG
D
GT
Q
P
---
G
DVDY
TV
S
TT
R
F
TTH
G
--
-
-
-
---Y
R
DH
S
GAQ
K
NL
A
N
A
-------
KLGVRIDDASK
L
S
L
IFNS
V
DIK
A
D
D
P
GG
LT
E
A
E
WK
A
NPQQ
A
P
RA
E
QYD
T
R
K
-----
TIK
Q
TQ
A
G
L
R
Y
ER
SL
SAQ
-----------------
D
D
M
S
V
M
M
Y
A
-------------
-
-
GERETTQ
Y
QS
I
P
M
----
APQL
N
PSHAGGVIT
L
Q
R
---
HYQ
G
I
D
-
---
-------
-
----
----
S
RWTQR
G
EL
GV
P
V
------
T
F
T
T
G
L
N
Y
ENM
S
EN
R
KGYNNFR
L
NR----
-
--
-
G
VPEYGQKGELRR
D
ER
N
L
MWN
V
DPYLQ
TQWQ
LTD
K
L
S
L
D
AG
V
RY
SSVWFDSN
DH
------------
YVTP
GN
GDDSGDASYH
K
W
L
P
AGS
L
KYA
M
T
D
A
W
N
V
Y
L
A
AG
RG
FET
P
T
I
N
E
------
L
SYRAD
G
---
--
QS
G
M--
-
-----
-
-
N
F
G
LKP
S
T
N
D
T
I
EIG
SKTRIGD
GL
L
S
-
L
A
L
F
Q
TD
TD
DE
IV
V
-------
D
S
SSGGRTT
Y
K
N
A
GK
T
R
RQ
G
A
E
L
A
WDQ
R
-
FAG
D
FRVKA
S
W
TW
L
DATYRSN
VC
N
EQ
DC
---
N
G
N
----
R
MP
G
I
A
RN
M
A
F
A
S
I
G
Y
IPE
D
GWYAGTEA
R
YM
G
D
IM
A
D--
-
--
----
--
-----
D
EN
T
AKAPS
YTLVGL
FTG
Y
K
Y
N
Y
HN
F
T
V
D
L
FGR
VDNLFDK
E
Y
VGSV
I
VNE
S
N
---
----
--
-----
-
-
G
R
---
Y
Y
E
PA
PGRNY
G
VG
I
N
fig|362663.9.peg.1470
Escherichia coli 536 (29-694/700)
MIVSA
APQVVSE
L
DT
P
A
A
VSV
V
DG
EE
M
R
L
A
-
TPRI
N
LSE
S
L
T
G
-
VPG
L
Q
V
QNR
Q
NY
A
Q-
-
-
D
LQ
L
SIRG
F
G
SRS
T
YGIRGIRLYV
DG
I
P
ATMPDG
--
QG
QT
S
N
I
D
L-
-
----
-
-
---
--
-
SS
VQNV
EVLRGP
F
SALYGN
-
A
S
GGV
M
N
VT
T
Q
T
G
Q
QPPTIEASSYYGSF
GS
W
RY
G
LK
A
TG
A
TG
D
GT
Q
P
---
G
DVDY
TV
S
TT
R
F
TTH
G
--
-
-
-
---Y
R
DH
S
GAQ
K
NL
A
N
A
-------
KLGVRIDDASK
L
S
L
IFNS
V
DIK
A
D
D
P
GG
LT
E
A
E
WK
A
NPQQ
A
P
RA
E
QYD
T
R
K
-----
TIK
Q
TQ
A
G
L
R
Y
ER
SL
SAQ
-----------------
D
D
M
S
V
M
M
Y
A
-------------
-
-
GERETTQ
Y
QS
I
P
M
----
APQL
N
PSHAGGVIT
L
Q
R
---
HYQ
G
I
D
-
---
-------
-
----
----
S
RWTQR
G
EL
GV
P
V
------
T
F
T
T
G
L
N
Y
ENM
S
EN
R
KGYNNFR
L
NR----
-
--
-
G
VPEYGQKGELRR
D
ER
N
L
MWN
V
DPYLQ
TQWQ
LTD
K
L
S
L
D
AG
V
RY
SSVWFDSN
DH
------------
YVTP
GN
GDDSGDASYH
K
W
L
P
AGS
L
KYA
M
T
D
A
W
N
V
Y
L
A
AG
RG
FET
P
T
I
N
E
------
L
SYRAD
G
---
--
QS
G
M--
-
-----
-
-
N
F
G
LKP
S
T
N
D
T
I
EIG
SKTRIGD
GL
L
S
-
L
A
L
F
Q
TD
TD
DE
IV
V
-------
D
S
SSGGRTT
Y
K
N
A
GK
T
R
RQ
G
A
E
L
A
WDQ
R
-
FAG
D
FRVKA
S
W
TW
L
DATYRSN
VC
N
EQ
DC
---
N
G
N
----
R
MP
G
I
A
RN
M
A
F
A
S
I
G
Y
IPE
D
GWYAGTEA
R
YM
G
D
IM
A
D--
-
--
----
--
-----
D
EN
T
AKAPS
YTLVGL
FTG
Y
K
Y
N
Y
HN
F
T
V
D
L
FGR
VDNLFDK
E
Y
VGSV
I
VNE
S
N
---
----
--
-----
-
-
G
R
---
Y
Y
E
PA
PGRNY
G
VG
I
N
fig|340197.3.peg.2988
Escherichia coli F11 (29-694/700)
MIVSA
APQVVSE
L
DT
P
A
A
VSV
V
DG
EE
M
R
L
A
-
TPRI
N
LSE
S
L
T
G
-
VPG
L
Q
V
QNR
Q
NY
A
Q-
-
-
D
LQ
L
SIRG
F
G
SRS
T
YGIRGIRLYV
DG
I
P
ATMPDG
--
QG
QT
S
N
I
D
L-
-
----
-
-
---
--
-
SS
VQNV
EVLRGP
F
SALYGN
-
A
S
GGV
M
N
VT
T
Q
T
G
Q
QPPTIEASSYYGSF
GS
W
RY
G
LK
A
TG
A
TG
D
GT
Q
P
---
G
DVDY
TV
S
TT
R
F
TTH
G
--
-
-
-
---Y
R
DH
S
GAQ
K
NL
A
N
A
-------
KLGVRIDDASK
L
S
L
IFNS
V
DIK
A
D
D
P
GG
LT
E
A
E
WK
A
NPQQ
A
P
RA
E
QYD
T
R
K
-----
TIK
Q
TQ
A
G
L
R
Y
ER
SL
SAQ
-----------------
D
D
M
S
V
M
M
Y
A
-------------
-
-
GERETTQ
Y
QS
I
P
M
----
APQL
N
PSHAGGVIT
L
Q
R
---
HYQ
G
I
D
-
---
-------
-
----
----
S
RWTQR
G
EL
GV
P
V
------
T
F
T
T
G
L
N
Y
ENM
S
EN
R
KGYNNFR
L
NR----
-
--
-
G
VPEYGQKGELRR
D
ER
N
L
MWN
V
DPYLQ
TQWQ
LTD
K
L
S
L
D
AG
V
RY
SSVWFDSN
DH
------------
YVTP
GN
GDDSGDASYH
K
W
L
P
AGS
L
KYA
M
T
D
A
W
N
V
Y
L
A
AG
RG
FET
P
T
I
N
E
------
L
SYRAD
G
---
--
QS
G
M--
-
-----
-
-
N
F
G
LKP
S
T
N
D
T
I
EIG
SKTRIGD
GL
L
S
-
L
A
L
F
Q
TD
TD
DE
IV
V
-------
D
S
SSGGRTT
Y
K
N
A
GK
T
R
RQ
G
A
E
L
A
WDQ
R
-
FAG
D
FRVKA
S
W
TW
L
DATYRSN
VC
N
EQ
DC
---
N
G
N
----
R
MP
G
I
A
RN
M
A
F
A
S
I
G
Y
IPE
D
GWYAGTEA
R
YM
G
D
IM
A
D--
-
--
----
--
-----
D
EN
T
AKAPS
YTLVGL
FTG
Y
K
Y
N
Y
HN
F
T
V
D
L
FGR
VDNLFDK
E
Y
VGSV
I
VNE
S
N
---
----
--
-----
-
-
G
R
---
Y
Y
E
PA
PGRNY
G
VG
I
N
fig|340197.5.peg.3121
Escherichia coli F11 (29-694/700)
MIVSA
APQVVSE
L
DT
P
A
A
VSV
V
DG
EE
M
R
L
A
-
TPRI
N
LSE
S
L
T
G
-
VPG
L
Q
V
QNR
Q
NY
A
Q-
-
-
D
LQ
L
SIRG
F
G
SRS
T
YGIRGIRLYV
DG
I
P
ATMPDG
--
QG
QT
S
N
I
D
L-
-
----
-
-
---
--
-
SS
VQNV
EVLRGP
F
SALYGN
-
A
S
GGV
M
N
VT
T
Q
T
G
Q
QPPTIEASSYYGSF
GS
W
RY
G
LK
A
TG
A
TG
D
GT
Q
P
---
G
DVDY
TV
S
TT
R
F
TTH
G
--
-
-
-
---Y
R
DH
S
GAQ
K
NL
A
N
A
-------
KLGVRIDDASK
L
S
L
IFNS
V
DIK
A
D
D
P
GG
LT
E
A
E
WK
A
NPQQ
A
P
RA
E
QYD
T
R
K
-----
TIK
Q
TQ
A
G
L
R
Y
ER
SL
SAQ
-----------------
D
D
M
S
V
M
M
Y
A
-------------
-
-
GERETTQ
Y
QS
I
P
M
----
APQL
N
PSHAGGVIT
L
Q
R
---
HYQ
G
I
D
-
---
-------
-
----
----
S
RWTQR
G
EL
GV
P
V
------
T
F
T
T
G
L
N
Y
ENM
S
EN
R
KGYNNFR
L
NR----
-
--
-
G
VPEYGQKGELRR
D
ER
N
L
MWN
V
DPYLQ
TQWQ
LTD
K
L
S
L
D
AG
V
RY
SSVWFDSN
DH
------------
YVTP
GN
GDDSGDASYH
K
W
L
P
AGS
L
KYA
M
T
D
A
W
N
V
Y
L
A
AG
RG
FET
P
T
I
N
E
------
L
SYRAD
G
---
--
QS
G
M--
-
-----
-
-
N
F
G
LKP
S
T
N
D
T
I
EIG
SKTRIGD
GL
L
S
-
L
A
L
F
Q
TD
TD
DE
IV
V
-------
D
S
SSGGRTT
Y
K
N
A
GK
T
R
RQ
G
A
E
L
A
WDQ
R
-
FAG
D
FRVKA
S
W
TW
L
DATYRSN
VC
N
EQ
DC
---
N
G
N
----
R
MP
G
I
A
RN
M
A
F
A
S
I
G
Y
IPE
D
GWYAGTEA
R
YM
G
D
IM
A
D--
-
--
----
--
-----
D
EN
T
AKAPS
YTLVGL
FTG
Y
K
Y
N
Y
HN
F
T
V
D
L
FGR
VDNLFDK
E
Y
VGSV
I
VNE
S
N
---
----
--
-----
-
-
G
R
---
Y
Y
E
PA
PGRNY
G
VG
I
N
fig|749550.3.peg.575
Escherichia coli MS 200-1 (29-694/700)
MIVSA
APQVVSE
L
DT
P
A
A
VSV
V
DG
EE
M
R
L
A
-
TPRI
N
LSE
S
L
T
G
-
VPG
L
Q
V
QNR
Q
NY
A
Q-
-
-
D
LQ
L
SIRG
F
G
SRS
T
YGIRGIRLYV
DG
I
P
ATMPDG
--
QG
QT
S
N
I
D
L-
-
----
-
-
---
--
-
SS
VQNV
EVLRGP
F
SALYGN
-
A
S
GGV
M
N
VT
T
Q
T
G
Q
QPPTIEASSYYGSF
GS
W
RY
G
LK
A
TG
A
TG
D
GT
Q
P
---
G
DVDY
TV
S
TT
R
F
TTH
G
--
-
-
-
---Y
R
DH
S
GAQ
K
NL
A
N
A
-------
KLGVRIDDASK
L
S
L
IFNS
V
DIK
A
D
D
P
GG
LT
E
A
E
WK
A
NPQQ
A
P
RA
E
QYD
T
R
K
-----
TIK
Q
TQ
A
G
L
R
Y
ER
SL
SAQ
-----------------
D
D
M
S
V
M
M
Y
A
-------------
-
-
GERETTQ
Y
QS
I
P
M
----
APQL
N
PSHAGGVIT
L
Q
R
---
HYQ
G
I
D
-
---
-------
-
----
----
S
RWTQR
G
EL
GV
P
V
------
T
F
T
T
G
L
N
Y
ENM
S
EN
R
KGYNNFR
L
NR----
-
--
-
G
VPEYGQKGELRR
D
ER
N
L
MWN
V
DPYLQ
TQWQ
LTD
K
L
S
L
D
AG
V
RY
SSVWFDSN
DH
------------
YVTP
GN
GDDSGDASYH
K
W
L
P
AGS
L
KYA
M
T
D
A
W
N
V
Y
L
A
AG
RG
FET
P
T
I
N
E
------
L
SYRAD
G
---
--
QS
G
M--
-
-----
-
-
N
F
G
LKP
S
T
N
D
T
I
EIG
SKTRIGD
GL
L
S
-
L
A
L
F
Q
TD
TD
DE
IV
V
-------
D
S
SSGGRTT
Y
K
N
A
GK
T
R
RQ
G
A
E
L
A
WDQ
R
-
FAG
D
FRVKA
S
W
TW
L
DATYRSN
VC
N
EQ
DC
---
N
G
N
----
R
MP
G
I
A
RN
M
A
F
A
S
I
G
Y
IPE
D
GWYAGTEA
R
YM
G
D
IM
A
D--
-
--
----
--
-----
D
EN
T
AKAPS
YTLVGL
FTG
Y
K
Y
N
Y
HN
F
T
V
D
L
FGR
VDNLFDK
E
Y
VGSV
I
VNE
S
N
---
----
--
-----
-
-
G
R
---
Y
Y
E
PA
PGRNY
G
VG
I
N
fig|656393.3.peg.2185
Escherichia coli H299 (29-694/700)
MIVSA
APQVISE
L
DT
P
A
A
VSV
V
DG
EE
M
R
L
A
-
TPRI
N
LSE
S
L
T
G
-
VPG
L
Q
V
QNR
Q
NY
A
Q-
-
-
D
LQ
L
SIRG
F
G
SRS
T
YGIRGIRLYV
DG
I
P
ATMPDG
--
QG
QT
S
N
I
D
L-
-
----
-
-
---
--
-
SS
VQNV
EVLRGP
F
SALYGN
-
A
S
GGV
M
N
V
IT
Q
T
G
Q
QPPTIEASSYYGSF
GS
W
RY
G
LK
A
TG
A
TG
D
GT
Q
P
---
G
DVDY
TV
S
TT
R
F
TTH
G
--
-
-
-
---Y
R
DH
S
GAQ
K
NL
A
N
A
-------
KLGVRIDDASK
L
S
L
IFNS
V
DIK
A
D
D
P
GG
LT
E
A
E
WK
A
NPQQ
A
P
RA
E
QYD
T
R
K
-----
TIK
Q
TQ
A
G
L
R
Y
ER
SL
SAQ
-----------------
D
D
M
S
V
M
M
Y
A
-------------
-
-
GERETTQ
Y
QS
I
P
M
----
S
PQL
N
PSHAGGVIT
L
Q
R
---
HYQ
G
I
D
-
---
-------
-
----
----
S
RWTHR
G
EL
GV
P
V
------
T
F
T
T
G
L
N
Y
ENM
S
EN
R
KGYNNFR
L
NR----
-
--
-
G
VPEYGQKGELRR
D
ER
N
L
MWN
V
DPYLQ
TQWQ
LTD
K
L
S
L
D
AG
V
RY
SSVWFDSN
DH
------------
YVTP
GN
GDDSGDASYH
K
W
L
P
AGS
L
KYA
M
T
D
A
W
N
V
Y
L
A
AG
RG
FET
P
T
I
N
E
------
L
SYRAD
G
---
--
QS
G
M--
-
-----
-
-
N
F
G
LKP
S
T
N
D
T
I
EIG
SKTRIGD
GL
L
S
-
L
A
L
F
Q
TD
TD
DE
IV
V
-------
D
S
SSGGRTT
Y
K
N
A
GK
T
R
RQ
G
A
E
L
A
WDQ
R
-
FAG
D
FRVKA
S
W
TW
L
DATYRSN
VC
N
EQ
DC
---
N
G
N
----
R
MP
G
I
A
RN
M
G
F
A
S
I
G
Y
VPE
D
GWYAGTEA
R
YM
G
D
IM
A
D--
-
--
----
--
-----
D
EN
T
AKAPS
YTLVGL
FTG
Y
K
Y
N
Y
HNL
T
V
D
L
FGR
VDNLFDK
E
Y
VGSV
I
VNE
S
N
---
----
--
-----
-
-
G
R
---
Y
Y
E
PA
PGRNY
G
VG
M
N
fig|405955.13.peg.1576
Escherichia coli APEC O1 (29-694/700)
MIVSA
APQVVSE
L
DT
P
A
A
VSV
V
DG
EE
M
R
L
A
-
TPRI
N
LSE
S
L
T
G
-
VPG
L
Q
V
QNR
Q
NY
A
Q-
-
-
D
LQ
L
SIRG
F
G
SRS
T
YGIRGIRLYV
DG
I
P
ATMPDG
--
QG
QT
S
N
I
D
L-
-
----
-
-
---
--
-
SS
VQNV
EVLRGP
F
SALYGN
-
A
S
GGV
M
N
VT
T
Q
T
G
Q
QPPTIEASSYYGSF
GS
W
RY
G
LK
A
TG
A
TG
D
GT
Q
P
---
G
DVDY
TV
S
TT
R
F
TTH
G
--
-
-
-
---Y
R
DH
S
GAQ
K
NL
A
N
A
-------
KLGVRIDDASK
L
S
L
IFNS
V
DIK
A
D
D
P
GG
LT
E
A
E
WK
A
NPQQ
A
P
RA
E
QYD
T
R
K
-----
TIK
Q
TQ
A
G
L
R
Y
ER
SL
SAQ
-----------------
D
D
M
S
V
M
M
Y
A
-------------
-
-
GERETTQ
Y
QS
I
P
M
----
APQL
N
PSHAGGVIT
L
Q
R
---
HYQ
G
I
D
-
---
-------
-
----
----
S
RWTHR
G
EL
GV
P
V
------
T
F
T
T
G
L
N
Y
ENM
S
EN
R
KGYNNFR
L
NR----
-
--
-
G
VPEYGQKGELRR
D
ER
N
L
MWN
V
DPYLQ
TQWQ
LTD
K
L
S
L
D
AG
V
RY
SSVWFDSN
DH
------------
YVTP
GN
GDDSGDASYH
K
W
L
P
AGS
L
KYA
M
T
D
A
W
N
V
Y
L
A
AG
RG
FET
P
T
I
N
E
------
L
SYRAD
G
---
--
QS
G
M--
-
-----
-
-
N
F
G
LKP
S
T
N
D
T
I
EIG
SKTRIGD
GL
L
S
-
L
A
L
F
Q
TD
TD
DE
IV
V
-------
D
S
SSGGRTT
Y
K
N
A
GK
T
R
RQ
G
A
E
L
A
WDQ
R
-
FAG
D
FRVKA
S
W
TW
L
DATYRSN
VC
N
EQ
DC
---
N
G
N
----
R
MP
G
I
A
RN
M
A
F
A
S
I
G
Y
IPE
D
GWYAGTEA
R
YM
G
D
IM
A
D--
-
--
----
--
-----
D
EN
T
AKAPS
YTLVGL
FTG
Y
K
Y
N
Y
HNL
T
V
D
L
FGR
VDNLFDK
E
Y
VGSV
I
VNE
S
N
---
----
--
-----
-
-
G
R
---
Y
Y
E
PA
PGRNY
G
VG
I
N
fig|405955.9.peg.1284
Escherichia coli APEC O1 (29-694/700)
MIVSA
APQVVSE
L
DT
P
A
A
VSV
V
DG
EE
M
R
L
A
-
TPRI
N
LSE
S
L
T
G
-
VPG
L
Q
V
QNR
Q
NY
A
Q-
-
-
D
LQ
L
SIRG
F
G
SRS
T
YGIRGIRLYV
DG
I
P
ATMPDG
--
QG
QT
S
N
I
D
L-
-
----
-
-
---
--
-
SS
VQNV
EVLRGP
F
SALYGN
-
A
S
GGV
M
N
VT
T
Q
T
G
Q
QPPTIEASSYYGSF
GS
W
RY
G
LK
A
TG
A
TG
D
GT
Q
P
---
G
DVDY
TV
S
TT
R
F
TTH
G
--
-
-
-
---Y
R
DH
S
GAQ
K
NL
A
N
A
-------
KLGVRIDDASK
L
S
L
IFNS
V
DIK
A
D
D
P
GG
LT
E
A
E
WK
A
NPQQ
A
P
RA
E
QYD
T
R
K
-----
TIK
Q
TQ
A
G
L
R
Y
ER
SL
SAQ
-----------------
D
D
M
S
V
M
M
Y
A
-------------
-
-
GERETTQ
Y
QS
I
P
M
----
APQL
N
PSHAGGVIT
L
Q
R
---
HYQ
G
I
D
-
---
-------
-
----
----
S
RWTHR
G
EL
GV
P
V
------
T
F
T
T
G
L
N
Y
ENM
S
EN
R
KGYNNFR
L
NR----
-
--
-
G
VPEYGQKGELRR
D
ER
N
L
MWN
V
DPYLQ
TQWQ
LTD
K
L
S
L
D
AG
V
RY
SSVWFDSN
DH
------------
YVTP
GN
GDDSGDASYH
K
W
L
P
AGS
L
KYA
M
T
D
A
W
N
V
Y
L
A
AG
RG
FET
P
T
I
N
E
------
L
SYRAD
G
---
--
QS
G
M--
-
-----
-
-
N
F
G
LKP
S
T
N
D
T
I
EIG
SKTRIGD
GL
L
S
-
L
A
L
F
Q
TD
TD
DE
IV
V
-------
D
S
SSGGRTT
Y
K
N
A
GK
T
R
RQ
G
A
E
L
A
WDQ
R
-
FAG
D
FRVKA
S
W
TW
L
DATYRSN
VC
N
EQ
DC
---
N
G
N
----
R
MP
G
I
A
RN
M
A
F
A
S
I
G
Y
IPE
D
GWYAGTEA
R
YM
G
D
IM
A
D--
-
--
----
--
-----
D
EN
T
AKAPS
YTLVGL
FTG
Y
K
Y
N
Y
HNL
T
V
D
L
FGR
VDNLFDK
E
Y
VGSV
I
VNE
S
N
---
----
--
-----
-
-
G
R
---
Y
Y
E
PA
PGRNY
G
VG
I
N
fig|714962.3.peg.1643
Escherichia coli IHE3034 (29-694/700)
MIVSA
APQVVSE
L
DT
P
A
A
VSV
V
DG
EE
M
R
L
A
-
TPRI
N
LSE
S
L
T
G
-
VPG
L
Q
V
QNR
Q
NY
A
Q-
-
-
D
LQ
L
SIRG
F
G
SRS
T
YGIRGIRLYV
DG
I
P
ATMPDG
--
QG
QT
S
N
I
D
L-
-
----
-
-
---
--
-
SS
VQNV
EVLRGP
F
SALYGN
-
A
S
GGV
M
N
VT
T
Q
T
G
Q
QPPTIEASSYYGSF
GS
W
RY
G
LK
A
TG
A
TG
D
GT
Q
P
---
G
DVDY
TV
S
TT
R
F
TTH
G
--
-
-
-
---Y
R
DH
S
GAQ
K
NL
A
N
A
-------
KLGVRIDDASK
L
S
L
IFNS
V
DIK
A
D
D
P
GG
LT
E
A
E
WK
A
NPQQ
A
P
RA
E
QYD
T
R
K
-----
TIK
Q
TQ
A
G
L
R
Y
ER
SL
SAQ
-----------------
D
D
M
S
V
M
M
Y
A
-------------
-
-
GERETTQ
Y
QS
I
P
M
----
APQL
N
PSHAGGVIT
L
Q
R
---
HYQ
G
I
D
-
---
-------
-
----
----
S
RWTHR
G
EL
GV
P
V
------
T
F
T
T
G
L
N
Y
ENM
S
EN
R
KGYNNFR
L
NR----
-
--
-
G
VPEYGQKGELRR
D
ER
N
L
MWN
V
DPYLQ
TQWQ
LTD
K
L
S
L
D
AG
V
RY
SSVWFDSN
DH
------------
YVTP
GN
GDDSGDASYH
K
W
L
P
AGS
L
KYA
M
T
D
A
W
N
V
Y
L
A
AG
RG
FET
P
T
I
N
E
------
L
SYRAD
G
---
--
QS
G
M--
-
-----
-
-
N
F
G
LKP
S
T
N
D
T
I
EIG
SKTRIGD
GL
L
S
-
L
A
L
F
Q
TD
TD
DE
IV
V
-------
D
S
SSGGRTT
Y
K
N
A
GK
T
R
RQ
G
A
E
L
A
WDQ
R
-
FAG
D
FRVKA
S
W
TW
L
DATYRSN
VC
N
EQ
DC
---
N
G
N
----
R
MP
G
I
A
RN
M
A
F
A
S
I
G
Y
IPE
D
GWYAGTEA
R
YM
G
D
IM
A
D--
-
--
----
--
-----
D
EN
T
AKAPS
YTLVGL
FTG
Y
K
Y
N
Y
HNL
T
V
D
L
FGR
VDNLFDK
E
Y
VGSV
I
VNE
S
N
---
----
--
-----
-
-
G
R
---
Y
Y
E
PA
PGRNY
G
VG
I
N
fig|869729.3.peg.2074
Escherichia coli UM146 (29-694/700)
MIVSA
APQVVSE
L
DT
P
A
A
VSV
V
DG
EE
M
R
L
A
-
TPRI
N
LSE
S
L
T
G
-
VPG
L
Q
V
QNR
Q
NY
A
Q-
-
-
D
LQ
L
SIRG
F
G
SRS
T
YGIRGIRLYV
DG
I
P
ATMPDG
--
QG
QT
S
N
I
D
L-
-
----
-
-
---
--
-
SS
VQNV
EVLRGP
F
SALYGN
-
A
S
GGV
M
N
VT
T
Q
T
G
Q
QPPTIEASSYYGSF
GS
W
RY
G
LK
A
TG
A
TG
D
GT
Q
P
---
G
DVDY
TV
S
TT
R
F
TTH
G
--
-
-
-
---Y
R
DH
S
GAQ
K
NL
A
N
A
-------
KLGVRIDDASK
L
S
L
IFNS
V
DIK
A
D
D
P
GG
LT
E
A
E
WK
A
NPQQ
A
P
RA
E
QYD
T
R
K
-----
TIK
Q
TQ
A
G
L
R
Y
ER
SL
SAQ
-----------------
D
D
M
S
V
M
M
Y
A
-------------
-
-
GERETTQ
Y
QS
I
P
M
----
APQL
N
PSHAGGVIT
L
Q
R
---
HYQ
G
I
D
-
---
-------
-
----
----
S
RWTHR
G
EL
GV
P
V
------
T
F
T
T
G
L
N
Y
ENM
S
EN
R
KGYNNFR
L
NR----
-
--
-
G
VPEYGQKGELRR
D
ER
N
L
MWN
V
DPYLQ
TQWQ
LTD
K
L
S
L
D
AG
V
RY
SSVWFDSN
DH
------------
YVTP
GN
GDDSGDASYH
K
W
L
P
AGS
L
KYA
M
T
D
A
W
N
V
Y
L
A
AG
RG
FET
P
T
I
N
E
------
L
SYRAD
G
---
--
QS
G
M--
-
-----
-
-
N
F
G
LKP
S
T
N
D
T
I
EIG
SKTRIGD
GL
L
S
-
L
A
L
F
Q
TD
TD
DE
IV
V
-------
D
S
SSGGRTT
Y
K
N
A
GK
T
R
RQ
G
A
E
L
A
WDQ
R
-
FAG
D
FRVKA
S
W
TW
L
DATYRSN
VC
N
EQ
DC
---
N
G
N
----
R
MP
G
I
A
RN
M
A
F
A
S
I
G
Y
IPE
D
GWYAGTEA
R
YM
G
D
IM
A
D--
-
--
----
--
-----
D
EN
T
AKAPS
YTLVGL
FTG
Y
K
Y
N
Y
HNL
T
V
D
L
FGR
VDNLFDK
E
Y
VGSV
I
VNE
S
N
---
----
--
-----
-
-
G
R
---
Y
Y
E
PA
PGRNY
G
VG
I
N
fig|364106.7.peg.1713
Escherichia coli UTI89 (29-694/700)
MIVSA
APQVVSE
L
DT
P
A
A
VSV
V
DG
EE
M
R
L
A
-
TPRI
N
LSE
S
L
T
G
-
VPG
L
Q
V
QNR
Q
NY
A
Q-
-
-
D
LQ
L
SIRG
F
G
SRS
T
YGIRGIRLYV
DG
I
P
ATMPDG
--
QG
QT
S
N
I
D
L-
-
----
-
-
---
--
-
SS
VQNV
EVLRGP
F
SALYGN
-
A
S
GGV
M
N
VT
T
Q
T
G
Q
QPPTIEASSYYGSF
GS
W
RY
G
LK
A
TG
A
TG
D
GT
Q
P
---
G
DVDY
TV
S
TT
R
F
TTH
G
--
-
-
-
---Y
R
DH
S
GAQ
K
NL
A
N
A
-------
KLGVRIDDASK
L
S
L
IFNS
V
DIK
A
D
D
P
GG
LT
E
A
E
WK
A
NPQQ
A
P
RA
E
QYD
T
R
K
-----
TIK
Q
TQ
A
G
L
R
Y
ER
SL
SAQ
-----------------
D
D
M
S
V
M
M
Y
A
-------------
-
-
GERETTQ
Y
QS
I
P
M
----
APQL
N
PSHAGGVIT
L
Q
R
---
HYQ
G
I
D
-
---
-------
-
----
----
S
RWTHR
G
EL
GV
P
V
------
T
F
T
T
G
L
N
Y
ENM
S
EN
R
KGYNNFR
L
NR----
-
--
-
G
VPEYGQKGELRR
D
ER
N
L
MWN
V
DPYLQ
TQWQ
LTD
K
L
S
L
D
AG
V
RY
SSVWFDSN
DH
------------
YVTP
GN
GDDSGDASYH
K
W
L
P
AGS
L
KYA
M
T
D
A
W
N
V
Y
L
A
AG
RG
FET
P
T
I
N
E
------
L
SYRAD
G
---
--
QS
G
M--
-
-----
-
-
N
F
G
LKP
S
T
N
D
T
I
EIG
SKTRIGD
GL
L
S
-
L
A
L
F
Q
TD
TD
DE
IV
V
-------
D
S
SSGGRTT
Y
K
N
A
GK
T
R
RQ
G
A
E
L
A
WDQ
R
-
FAG
D
FRVKA
S
W
TW
L
DATYRSN
VC
N
EQ
DC
---
N
G
N
----
R
MP
G
I
A
RN
M
A
F
A
S
I
G
Y
IPE
D
GWYAGTEA
R
YM
G
D
IM
A
D--
-
--
----
--
-----
D
EN
T
AKAPS
YTLVGL
FTG
Y
K
Y
N
Y
HNL
T
V
D
L
FGR
VDNLFDK
E
Y
VGSV
I
VNE
S
N
---
----
--
-----
-
-
G
R
---
Y
Y
E
PA
PGRNY
G
VG
I
N
fig|364106.8.peg.1714
Escherichia coli UTI89 (29-694/700)
MIVSA
APQVVSE
L
DT
P
A
A
VSV
V
DG
EE
M
R
L
A
-
TPRI
N
LSE
S
L
T
G
-
VPG
L
Q
V
QNR
Q
NY
A
Q-
-
-
D
LQ
L
SIRG
F
G
SRS
T
YGIRGIRLYV
DG
I
P
ATMPDG
--
QG
QT
S
N
I
D
L-
-
----
-
-
---
--
-
SS
VQNV
EVLRGP
F
SALYGN
-
A
S
GGV
M
N
VT
T
Q
T
G
Q
QPPTIEASSYYGSF
GS
W
RY
G
LK
A
TG
A
TG
D
GT
Q
P
---
G
DVDY
TV
S
TT
R
F
TTH
G
--
-
-
-
---Y
R
DH
S
GAQ
K
NL
A
N
A
-------
KLGVRIDDASK
L
S
L
IFNS
V
DIK
A
D
D
P
GG
LT
E
A
E
WK
A
NPQQ
A
P
RA
E
QYD
T
R
K
-----
TIK
Q
TQ
A
G
L
R
Y
ER
SL
SAQ
-----------------
D
D
M
S
V
M
M
Y
A
-------------
-
-
GERETTQ
Y
QS
I
P
M
----
APQL
N
PSHAGGVIT
L
Q
R
---
HYQ
G
I
D
-
---
-------
-
----
----
S
RWTHR
G
EL
GV
P
V
------
T
F
T
T
G
L
N
Y
ENM
S
EN
R
KGYNNFR
L
NR----
-
--
-
G
VPEYGQKGELRR
D
ER
N
L
MWN
V
DPYLQ
TQWQ
LTD
K
L
S
L
D
AG
V
RY
SSVWFDSN
DH
------------
YVTP
GN
GDDSGDASYH
K
W
L
P
AGS
L
KYA
M
T
D
A
W
N
V
Y
L
A
AG
RG
FET
P
T
I
N
E
------
L
SYRAD
G
---
--
QS
G
M--
-
-----
-
-
N
F
G
LKP
S
T
N
D
T
I
EIG
SKTRIGD
GL
L
S
-
L
A
L
F
Q
TD
TD
DE
IV
V
-------
D
S
SSGGRTT
Y
K
N
A
GK
T
R
RQ
G
A
E
L
A
WDQ
R
-
FAG
D
FRVKA
S
W
TW
L
DATYRSN
VC
N
EQ
DC
---
N
G
N
----
R
MP
G
I
A
RN
M
A
F
A
S
I
G
Y
IPE
D
GWYAGTEA
R
YM
G
D
IM
A
D--
-
--
----
--
-----
D
EN
T
AKAPS
YTLVGL
FTG
Y
K
Y
N
Y
HNL
T
V
D
L
FGR
VDNLFDK
E
Y
VGSV
I
VNE
S
N
---
----
--
-----
-
-
G
R
---
Y
Y
E
PA
PGRNY
G
VG
I
N
fig|550677.3.peg.2859
Escherichia coli B354 (1-666/672)
MIVSA
TPQVVSE
L
DT
P
A
A
VSV
V
DG
EE
M
R
L
A
-
TPRI
N
LSE
S
L
T
G
-
VPG
L
Q
V
QNR
Q
NY
A
Q-
-
-
D
LQ
L
SIRG
F
G
SRS
T
YGIRGIRLYV
DG
I
P
ATMPDG
--
QG
QT
S
N
I
D
L-
-
----
-
-
---
--
-
SS
VQNV
EVLRGP
F
SALYGN
-
A
S
GGV
M
N
V
IT
Q
T
G
Q
QPPTIEASSYYGSF
GS
W
RY
G
LK
A
TG
A
TG
D
GT
Q
P
---
G
DVDY
TV
S
TT
R
F
TTH
G
--
-
-
-
---Y
R
DH
S
GAQ
K
NL
A
N
A
-------
KLGVRIDDASK
L
S
L
IFNS
V
DIK
A
D
D
P
GG
LT
E
A
E
WK
A
NPQQ
A
P
RA
E
QYD
T
R
K
-----
TIK
Q
TQ
A
G
L
R
Y
ER
SL
SSR
-----------------
D
D
M
S
M
M
M
Y
A
-------------
-
-
GERETTQ
Y
QP
I
P
M
----
L
PQL
N
PSHAGGVIT
L
Q
R
---
HYQ
G
I
D
-
---
-------
-
----
----
S
RWTHR
G
EL
GV
P
V
------
T
F
T
T
G
L
N
Y
ENM
S
EN
R
KGYNNFR
L
NS----
-
--
-
G
VPEYGQKGELRR
D
ER
N
L
MWN
V
DPYLQ
TQWQ
L
SE
K
L
S
L
D
AG
V
RY
SSVWFDSN
DH
------------
YVTP
GN
GDDSGD
V
SYH
K
W
L
P
AGS
L
KYA
M
T
D
A
W
N
I
Y
L
A
AG
RG
FET
P
T
I
N
E
------
L
SYLAD
G
---
--
QS
G
M--
-
-----
-
-
N
F
G
LKP
S
T
N
D
T
I
EIG
SKTRIGY
GL
L
S
-
L
A
L
F
Q
TD
TD
DE
IV
V
-------
D
S
SSGGRTT
Y
K
N
A
GK
T
R
RQ
G
A
E
L
A
WDQ
R
-
FAE
D
FRVKA
S
W
TW
L
DATYRSN
VC
N
EQ
DC
---
N
G
N
----
R
MP
G
I
A
RN
M
G
F
A
S
I
G
Y
VPE
D
GWYAGTEA
R
YM
G
D
IM
A
D--
-
--
----
--
-----
D
EN
T
AKAPS
YTLVGL
FTG
Y
K
Y
N
Y
HNL
T
V
D
L
FGR
VDNLFDK
E
Y
VGSV
I
VNE
S
N
---
----
--
-----
-
-
G
R
---
Y
Y
E
PA
PGRNY
G
VG
M
N
fig|670897.3.peg.4892
Escherichia coli 2362-75 (29-694/700)
MIVSA
APQVVSE
L
DT
P
A
A
VSV
V
DG
EE
M
R
L
A
-
TPRI
N
LSE
S
L
T
G
-
VPG
L
Q
V
QNR
Q
NY
A
Q-
-
-
D
LQ
L
SIRG
F
G
SRS
T
YGIRGIRLYV
DG
I
P
ATMPDG
--
QG
QT
S
N
I
D
L-
-
----
-
-
---
--
-
SS
VQNV
EVLRGP
F
SALYGN
-
A
S
GGV
M
N
VT
T
Q
T
G
Q
QPPTIEASSYYGSF
GS
W
RY
G
LK
A
TG
A
TG
D
GT
Q
P
---
G
D
F
DY
TV
S
TT
R
F
TTH
G
--
-
-
-
---Y
R
DH
S
GAQ
K
NL
A
N
A
-------
KLGVRIDDASK
L
S
L
IFNS
V
DIK
A
D
D
P
GG
LT
E
A
E
WK
A
NPQQ
A
P
RA
E
QYD
T
R
K
-----
TIK
Q
TQ
A
G
L
R
Y
ER
SL
SAQ
-----------------
D
D
M
S
V
M
M
Y
A
-------------
-
-
GERETTQ
Y
QS
I
P
M
----
APQL
N
PSHAGGVIT
L
Q
R
---
HYQ
G
I
D
-
---
-------
-
----
----
S
RWTHR
G
EL
GV
P
V
------
T
L
S
T
G
L
N
Y
ENM
S
EN
R
KGYNNFR
L
NR----
-
--
-
G
VPEYGQKGELRR
D
ER
N
L
MWN
V
DPYLQ
TQWQ
LTD
K
L
S
L
D
AG
V
RY
SSVWFDSN
DH
------------
YVTP
GN
GDDSGDASYH
K
W
L
P
AGS
L
KYA
M
T
D
A
W
N
V
Y
L
A
AG
RG
FET
P
T
I
N
E
------
L
SYRAD
G
---
--
QS
G
M--
-
-----
-
-
N
F
G
LKP
S
T
N
D
T
I
EIG
SKTRIGD
GL
L
S
-
L
A
L
F
Q
TD
TD
DE
IV
V
-------
D
S
SSGGRTI
Y
K
N
A
GK
T
R
RQ
G
A
E
L
A
WDQ
R
-
FAG
D
FRVKA
S
W
TW
L
DATYRSN
VC
N
EQ
DC
---
N
G
N
----
R
MP
G
I
A
RN
M
A
F
A
S
I
G
Y
IPE
D
GWYAGTEA
R
YM
G
D
IM
A
D--
-
--
----
--
-----
D
EN
T
AKAPS
YTLVGL
FTG
Y
K
Y
N
Y
HNL
T
V
D
L
FGR
VDNLFDK
E
Y
VGSV
I
VNE
S
N
---
----
--
-----
-
-
G
R
---
Y
Y
E
PA
PGRNY
G
VG
I
N
fig|216593.1.peg.262
Escherichia coli E2348/69 (29-694/700)
MIVSA
APQVVSE
L
DT
P
A
A
VSV
V
DG
EE
M
R
L
A
-
TPRI
N
LSE
S
L
T
G
-
VPG
L
Q
V
QNR
Q
NY
A
Q-
-
-
D
LQ
L
SIRG
F
G
SRS
T
YGIRGIRLYV
DG
I
P
ATMPDG
--
QG
QT
S
N
I
D
L-
-
----
-
-
---
--
-
SS
VQNV
EVLRGP
F
SALYGN
-
A
S
GGV
M
N
VT
T
Q
T
G
Q
QPPTIEASSYYGSF
GS
W
RY
G
LK
A
TG
A
TG
D
GT
Q
P
---
G
D
F
DY
TV
S
TT
R
F
TTH
G
--
-
-
-
---Y
R
DH
S
GAQ
K
NL
A
N
A
-------
KLGVRIDDASK
L
S
L
IFNS
V
DIK
A
D
D
P
GG
LT
E
A
E
WK
A
NPQQ
A
P
RA
E
QYD
T
R
K
-----
TIK
Q
TQ
A
G
L
R
Y
ER
SL
SAQ
-----------------
D
D
M
S
V
M
M
Y
A
-------------
-
-
GERETTQ
Y
QS
I
P
M
----
APQL
N
PSHAGGVIT
L
Q
R
---
HYQ
G
I
D
-
---
-------
-
----
----
S
RWTHR
G
EL
GV
P
V
------
T
L
S
T
G
L
N
Y
ENM
S
EN
R
KGYNNFR
L
NR----
-
--
-
G
VPEYGQKGELRR
D
ER
N
L
MWN
V
DPYLQ
TQWQ
LTD
K
L
S
L
D
AG
V
RY
SSVWFDSN
DH
------------
YVTP
GN
GDDSGDASYH
K
W
L
P
AGS
L
KYA
M
T
D
A
W
N
V
Y
L
A
AG
RG
FET
P
T
I
N
E
------
L
SYRAD
G
---
--
QS
G
M--
-
-----
-
-
N
F
G
LKP
S
T
N
D
T
I
EIG
SKTRIGD
GL
L
S
-
L
A
L
F
Q
TD
TD
DE
IV
V
-------
D
S
SSGGRTI
Y
K
N
A
GK
T
R
RQ
G
A
E
L
A
WDQ
R
-
FAG
D
FRVKA
S
W
TW
L
DATYRSN
VC
N
EQ
DC
---
N
G
N
----
R
MP
G
I
A
RN
M
A
F
A
S
I
G
Y
IPE
D
GWYAGTEA
R
YM
G
D
IM
A
D--
-
--
----
--
-----
D
EN
T
AKAPS
YTLVGL
FTG
Y
K
Y
N
Y
HNL
T
V
D
L
FGR
VDNLFDK
E
Y
VGSV
I
VNE
S
N
---
----
--
-----
-
-
G
R
---
Y
Y
E
PA
PGRNY
G
VG
I
N
fig|574521.7.peg.1627
Escherichia coli O127:H6 str. E2348/69 (29-694/700)
MIVSA
APQVVSE
L
DT
P
A
A
VSV
V
DG
EE
M
R
L
A
-
TPRI
N
LSE
S
L
T
G
-
VPG
L
Q
V
QNR
Q
NY
A
Q-
-
-
D
LQ
L
SIRG
F
G
SRS
T
YGIRGIRLYV
DG
I
P
ATMPDG
--
QG
QT
S
N
I
D
L-
-
----
-
-
---
--
-
SS
VQNV
EVLRGP
F
SALYGN
-
A
S
GGV
M
N
VT
T
Q
T
G
Q
QPPTIEASSYYGSF
GS
W
RY
G
LK
A
TG
A
TG
D
GT
Q
P
---
G
D
F
DY
TV
S
TT
R
F
TTH
G
--
-
-
-
---Y
R
DH
S
GAQ
K
NL
A
N
A
-------
KLGVRIDDASK
L
S
L
IFNS
V
DIK
A
D
D
P
GG
LT
E
A
E
WK
A
NPQQ
A
P
RA
E
QYD
T
R
K
-----
TIK
Q
TQ
A
G
L
R
Y
ER
SL
SAQ
-----------------
D
D
M
S
V
M
M
Y
A
-------------
-
-
GERETTQ
Y
QS
I
P
M
----
APQL
N
PSHAGGVIT
L
Q
R
---
HYQ
G
I
D
-
---
-------
-
----
----
S
RWTHR
G
EL
GV
P
V
------
T
L
S
T
G
L
N
Y
ENM
S
EN
R
KGYNNFR
L
NR----
-
--
-
G
VPEYGQKGELRR
D
ER
N
L
MWN
V
DPYLQ
TQWQ
LTD
K
L
S
L
D
AG
V
RY
SSVWFDSN
DH
------------
YVTP
GN
GDDSGDASYH
K
W
L
P
AGS
L
KYA
M
T
D
A
W
N
V
Y
L
A
AG
RG
FET
P
T
I
N
E
------
L
SYRAD
G
---
--
QS
G
M--
-
-----
-
-
N
F
G
LKP
S
T
N
D
T
I
EIG
SKTRIGD
GL
L
S
-
L
A
L
F
Q
TD
TD
DE
IV
V
-------
D
S
SSGGRTI
Y
K
N
A
GK
T
R
RQ
G
A
E
L
A
WDQ
R
-
FAG
D
FRVKA
S
W
TW
L
DATYRSN
VC
N
EQ
DC
---
N
G
N
----
R
MP
G
I
A
RN
M
A
F
A
S
I
G
Y
IPE
D
GWYAGTEA
R
YM
G
D
IM
A
D--
-
--
----
--
-----
D
EN
T
AKAPS
YTLVGL
FTG
Y
K
Y
N
Y
HNL
T
V
D
L
FGR
VDNLFDK
E
Y
VGSV
I
VNE
S
N
---
----
--
-----
-
-
G
R
---
Y
Y
E
PA
PGRNY
G
VG
I
N
fig|656440.3.peg.1317
Escherichia coli TA206 (1-666/672)
MIVSA
ASQVVSE
L
DT
P
A
A
VSV
V
DG
EE
M
R
L
A
-
TPRI
N
LSE
S
L
T
G
-
VPG
L
Q
V
QNR
Q
NY
A
Q-
-
-
D
LQ
L
SIRG
F
G
SRS
T
YGIRGIRLYV
DG
I
P
ATMPDG
--
QG
QT
S
N
I
D
L-
-
----
-
-
---
--
-
SS
VQNV
EVLRGP
F
SALYGN
-
A
S
GGV
M
N
VT
T
Q
T
G
Q
QPPTIEASSYYGSF
GS
W
RY
G
LK
A
TG
A
TG
D
GT
Q
P
---
G
DVDY
TV
S
TT
R
F
TTH
G
--
-
-
-
---Y
R
DH
S
GAQ
K
NL
A
N
A
-------
KLGVRIDDASK
L
S
L
IFNS
V
DIK
A
D
D
P
GG
LT
KA
E
WK
A
NPQQ
A
P
RA
E
QYD
T
R
K
-----
TIK
Q
TQ
A
G
L
R
Y
ER
SL
SAQ
-----------------
D
D
M
S
V
M
M
Y
A
-------------
-
-
GERETTQ
Y
QS
I
P
M
----
APQL
N
PSHAGGVIT
L
Q
R
---
HYQ
G
I
D
-
---
-------
-
----
----
S
RWTHR
G
EL
GV
P
L
------
T
F
T
T
G
L
N
Y
ENM
S
EN
R
KGYNNFR
L
NS----
-
--
-
G
VPEYGQKGELRR
D
ER
N
L
MWN
V
DP
F
LQ
TQWQ
L
SE
K
L
S
L
D
AG
V
RY
SSVWFDSN
DH
------------
YVTP
GN
GDDSGDASYH
K
W
L
P
AGS
L
KYA
M
T
D
A
W
N
I
Y
L
A
AG
RG
FET
P
T
I
N
E
------
L
SYRAD
G
---
--
QS
G
M--
-
-----
-
-
N
F
G
LKP
S
T
N
D
T
I
EIG
SKTRIGD
GL
L
S
-
L
A
L
F
Q
TD
TD
DE
IV
V
-------
D
S
SSGGRTT
Y
K
N
A
GK
T
R
RQ
G
A
E
L
A
WDQ
R
-
FAG
D
FRVKA
S
W
TW
L
DATYRSN
VC
N
EQ
DC
---
N
G
N
----
R
MP
G
I
A
RN
M
G
F
A
S
I
G
Y
IPE
D
GWYAGTEA
R
YM
G
D
IM
A
D--
-
--
----
--
-----
D
EN
T
AKAPS
YTLVGL
FTG
Y
K
Y
N
Y
HN
F
T
V
D
L
FGR
VDNLFDK
E
Y
VGSV
I
VNE
S
N
---
----
--
-----
-
-
G
R
---
Y
Y
E
PA
PGRNY
G
VG
I
N
fig|562.376.peg.3052
Escherichia coli WV_060327 (29-694/700)
MIVSA
APQVVSE
L
DI
P
A
A
VSV
V
DG
EE
M
R
L
A
-
TPRI
N
LSE
S
L
T
G
-
VPG
L
Q
V
QNR
Q
NY
A
Q-
-
-
D
LQ
L
SIRG
F
G
SRS
T
YGIRGIRLYV
DG
I
P
ATMPDG
--
QG
QT
S
N
I
D
L-
-
----
-
-
---
--
-
SS
VQNV
EVLRGP
F
SALYGN
-
A
S
GGV
M
N
VT
T
Q
T
G
Q
QPPTIEASSYYGSF
GS
W
RY
G
LK
A
TG
A
TG
D
GT
Q
P
---
G
DVDY
TV
S
TT
R
F
TTH
G
--
-
-
-
---Y
R
DH
S
GAQ
K
NL
A
N
A
-------
KLGVRIDDASK
L
S
L
IFNS
V
DIK
A
D
D
P
GG
LT
E
A
E
WK
A
NPQQ
A
P
RA
E
QYD
T
R
K
-----
TIK
Q
TQ
A
G
L
R
Y
ER
SL
SAQ
-----------------
D
D
M
S
V
M
M
Y
A
-------------
-
-
GERETTQ
Y
QS
I
P
M
----
APQL
N
PSHAGGVIT
L
Q
R
---
HYQ
G
I
D
-
---
-------
-
----
----
S
RWTHR
G
EL
GV
P
V
------
T
F
T
T
G
L
N
Y
ENM
S
EN
R
KGYNNFR
L
NR----
-
--
-
G
VPEYGQKGELRR
D
ER
N
L
MWN
V
DPYLQ
TQWQ
LTD
K
L
S
L
D
AG
V
RY
SSVWFDSN
DH
------------
YVTP
GN
GDDSGDASYH
K
W
L
P
AGS
L
KYA
M
T
D
A
W
N
I
Y
L
A
AG
RG
FET
P
T
I
N
E
------
L
SYRAD
G
---
--
QS
G
M--
-
-----
-
-
N
F
G
LKP
S
T
N
D
T
I
EIG
SKTRIGD
GL
L
S
-
L
A
L
F
Q
TD
TD
DE
IV
V
-------
D
S
SSGGRTT
Y
K
N
A
GK
T
R
RQ
G
A
E
L
A
WDQ
R
-
FAG
D
FRVKA
S
W
TW
L
DATYRSN
VC
N
EQ
DC
---
N
G
N
----
R
MP
G
I
A
RN
M
G
F
A
S
I
G
Y
VPE
D
GWYAGTEA
R
YM
G
D
IM
A
D--
-
--
----
--
-----
D
EN
T
AKAPS
YTLVGL
FTG
Y
K
Y
N
Y
HNL
T
V
D
L
FGR
VDNLFDK
E
Y
VGSV
I
VNE
S
N
---
----
--
-----
-
-
G
R
---
Y
Y
E
PA
PGRNY
G
VG
I
N
fig|749531.3.peg.5046
Escherichia coli MS 69-1 (1-666/672)
MIVSA
APQVVSE
L
DT
P
A
A
VSV
V
DG
EE
M
R
L
A
-
TPRI
N
LSE
S
L
T
S
-
VPG
L
Q
V
QNR
Q
NY
A
Q-
-
-
D
LQ
L
SIRG
F
G
SRS
T
YGIRGIRLYV
DG
I
P
ATMPDG
--
QG
QT
S
N
I
D
L-
-
----
-
-
---
--
-
SS
VQNV
EVLRGP
F
SALYGN
-
A
S
GGV
M
N
V
IT
Q
T
G
Q
QPPTIEASSYYGSF
GS
W
RY
G
LK
A
TG
A
MG
D
GT
Q
P
---
G
DVDY
TV
S
TT
R
F
TTH
G
--
-
-
-
---Y
R
DH
S
GAQ
K
NL
A
N
A
-------
KLGVRIDDASK
L
S
L
IFNS
V
DIK
A
D
D
P
GG
LT
E
A
E
WK
A
NPQQ
A
P
RA
E
QYD
T
R
K
-----
TIK
Q
TQ
A
G
L
R
Y
ER
SL
SAQ
-----------------
D
D
M
S
V
M
M
Y
A
-------------
-
-
GERETTQ
Y
QS
I
P
M
----
APQL
N
PSHAGGVIT
L
Q
R
---
HYQ
G
I
D
-
---
-------
-
----
----
S
RWTHR
G
EL
GV
P
L
------
T
F
T
T
G
L
N
Y
ENM
S
EN
R
KGYNNFR
L
NS----
-
--
-
G
VPEYGQKGELRR
D
ER
N
L
MWN
V
DPYLQ
TQWQ
L
SE
K
L
S
L
D
AG
V
RY
SSVWFDSN
DH
------------
YVTS
GN
GDDSGDASYH
K
W
L
P
AGS
L
KYA
M
T
D
A
W
N
I
Y
L
A
AG
RG
FET
P
T
I
N
E
------
L
SYRAD
G
---
--
QS
G
M--
-
-----
-
-
N
F
G
LKP
S
T
N
D
T
I
EIG
SKTRIGD
GL
L
S
-
L
A
L
F
Q
TD
TD
DE
IV
V
-------
D
S
SSGGRTT
Y
K
N
A
GK
T
R
RQ
G
A
E
L
A
WDQ
R
-
FAG
D
FRVKA
S
W
TW
L
DATYRSN
VC
N
EQ
DC
---
N
G
N
----
R
MP
G
I
A
RN
M
G
F
A
S
I
G
Y
VPE
D
GWYAGTEA
R
YM
G
D
IM
A
D--
-
--
----
--
-----
D
EN
T
AKAPS
YTLVGL
FTG
Y
K
Y
N
Y
HNL
T
V
D
L
FGR
VDNLFDK
E
Y
VGSV
I
VNE
S
N
---
----
--
-----
-
-
G
R
---
Y
Y
E
PA
PGRNY
G
VG
M
N
fig|749527.3.peg.3747
Escherichia coli MS 21-1 (73-738/744)
MIVSA
APQVVSE
L
DT
P
A
A
VSV
V
DG
EE
M
R
L
A
-
TPRI
N
LSE
S
L
T
G
-
VPG
L
Q
V
QNR
Q
NY
A
Q-
-
-
D
LQ
L
SIRG
F
G
SRS
T
YGIRGIRLYV
DG
I
P
ATMPDG
--
QG
QT
S
N
I
D
L-
-
----
-
-
---
--
-
SS
VQNV
EVLRGP
F
SALYGN
-
A
S
GGV
M
N
V
IT
Q
T
G
Q
QPPTIEASSYYGSF
GS
W
RY
G
LK
A
TG
A
TG
D
GT
Q
P
---
G
DVDY
TV
S
TT
R
F
TTH
G
--
-
-
-
---Y
R
DH
S
GAQ
K
NL
A
N
A
-------
KLGVRIDEASK
L
S
L
IFNS
V
DIK
A
D
D
P
GG
LT
KA
E
WK
A
NPQQ
A
P
RA
E
QYD
T
R
K
-----
TIK
Q
TQ
A
G
L
R
Y
ER
SL
SAQ
-----------------
D
D
M
S
V
M
M
Y
A
-------------
-
-
GERETTQ
Y
QS
I
P
M
----
APQL
N
PSHAGGVIT
L
Q
R
---
HYQ
G
I
D
-
---
-------
-
----
----
S
RWTHR
G
EL
GV
P
L
------
T
F
T
T
G
L
N
Y
ENM
S
EN
R
KGYNNFR
L
NS----
-
--
-
G
VPEYGQKGELRR
D
ER
N
L
MWN
V
DPYLQ
TQWQ
L
SE
K
L
S
L
D
AG
V
RY
SSVWFDSN
DH
------------
YVTP
GN
GDDSGDASYH
K
W
L
P
AGS
L
KYA
M
T
D
A
W
N
I
Y
L
A
AG
RG
FET
P
T
I
N
E
------
L
SYRAD
G
---
--
QS
G
M--
-
-----
-
-
N
F
G
LKP
S
T
N
D
T
I
EIG
SKTRIGD
GL
L
S
-
L
A
L
F
Q
TD
TD
DE
IV
V
-------
D
S
SSGGRTT
Y
K
N
A
GK
T
R
RQ
G
A
E
L
A
WDQ
R
-
FAG
D
FRVKA
S
W
TW
L
DATYRSN
VC
N
EQ
DC
---
N
G
N
----
R
MP
G
I
A
RN
M
G
F
A
S
I
G
Y
VPE
D
GWYAGTEA
R
YM
G
D
IM
A
D--
-
--
----
--
-----
D
EN
T
AKAPS
YTLVGL
FTG
Y
K
Y
N
Y
HNL
T
V
D
L
FGR
VDNLFDK
E
Y
VGSV
I
VNE
S
N
---
----
--
-----
-
-
G
R
---
Y
Y
E
PA
PGRNY
G
VG
M
N
fig|439855.10.peg.1877
Escherichia coli SMS-3-5 (1-666/672)
MIVSA
APQVVSE
L
DT
P
A
A
VSV
V
DG
EE
M
R
L
A
-
TPRI
N
LSE
S
L
T
G
-
VPG
L
Q
V
QNR
Q
NY
A
Q-
-
-
D
LQ
L
SIRG
F
G
SRS
T
YGIRGIRLYV
DG
I
P
ATMPDG
--
QG
QT
S
N
I
D
L-
-
----
-
-
---
--
-
SS
VQNV
EVLRGP
F
SALYGN
-
A
S
GGV
M
N
V
IT
Q
T
G
Q
QPPTIEASSYYGSF
GS
W
RY
G
LK
A
TG
A
TG
D
GT
Q
P
---
G
DVDY
TV
S
TT
R
F
TTH
G
--
-
-
-
---Y
R
DH
S
GAQ
K
NL
A
N
A
-------
KLGVRIDEASK
L
S
L
IFNS
V
DIK
A
D
D
P
GG
LT
E
A
E
WK
A
NPQQ
A
P
RA
E
QYD
T
R
K
-----
TIK
Q
TQ
A
G
L
R
Y
ER
SL
SAQ
-----------------
D
D
M
S
V
M
M
Y
A
-------------
-
-
GERETTQ
Y
QS
I
P
M
----
APQL
N
PSHAGGVIT
L
Q
R
---
HYQ
G
I
D
-
---
-------
-
----
----
S
RWTHH
G
EL
GV
P
V
------
T
F
T
T
G
L
N
Y
ENM
S
EN
R
KGYNNFR
L
NS----
-
--
-
G
VPEYGQKGELRR
D
ER
N
L
MWN
V
DPYLQ
TQWQ
L
SE
K
L
S
L
D
AG
V
RY
SSVWFDSN
DH
------------
YVTP
GN
GDDSGDASYH
K
W
L
P
AGS
L
KYA
M
N
D
A
W
N
I
Y
L
A
AG
RG
FET
P
T
I
N
E
------
L
SYRAD
G
---
--
QS
G
M--
-
-----
-
-
N
F
G
LKP
S
T
N
D
T
I
EIG
SKTRIGD
GL
L
S
-
L
A
L
F
Q
TD
TD
DE
IV
V
-------
D
S
SSGGRTT
Y
K
N
A
GK
T
R
RQ
G
A
E
L
A
WDQ
R
-
FAG
D
FRVKA
S
W
TW
L
DATYRSN
VC
N
EQ
DC
---
N
G
N
----
R
MP
G
I
A
RN
M
G
F
A
S
I
G
Y
VPE
E
GWYAGTEA
R
YM
G
D
IM
A
D--
-
--
----
--
-----
D
EN
T
AKAPS
YTLVGL
FTG
Y
K
Y
N
Y
HNL
T
V
D
L
FGR
VDNLFDK
G
Y
VGSV
I
VNE
S
N
---
----
--
-----
-
-
G
R
---
Y
Y
E
PA
PGRNY
G
VG
M
N
fig|216592.1.peg.1989
Escherichia coli 042 (82-747/753)
MIVSA
TPQVVSE
L
DT
P
A
A
VSV
V
DG
EE
M
R
L
A
-
TPRI
N
LSE
S
L
T
S
-
VPG
L
Q
V
QNR
Q
NY
A
Q-
-
-
D
LQ
L
SIRG
F
G
SRS
T
YGIRGIRLYV
DG
I
P
ATMPDG
--
QG
QT
S
N
I
D
L-
-
----
-
-
---
--
-
SS
VQNV
EVLRGP
F
SALYGN
-
A
S
GGV
M
N
V
IT
Q
T
G
Q
QPPTIEASSYYGSF
GS
W
RY
G
LK
A
TG
A
MG
D
GT
Q
P
---
G
DVDY
TV
S
TT
R
F
TTH
G
--
-
-
-
---Y
R
DH
S
GAQ
K
NL
A
N
A
-------
KLGVRIDDASK
L
S
L
IFNS
V
DIK
A
D
D
P
GG
LT
E
A
E
WK
A
NPQQ
A
P
RA
E
QYD
T
R
K
-----
TIK
Q
TQ
A
G
L
R
Y
ER
SL
SAQ
-----------------
D
D
M
S
V
M
M
Y
A
-------------
-
-
GERETTQ
Y
QS
I
P
M
----
APQL
N
PSHAGGVIT
L
Q
R
---
HYQ
G
I
D
-
---
-------
-
----
----
S
RWTHR
G
EL
GV
P
L
------
T
F
T
T
G
L
N
Y
ENM
S
EN
R
KGYNNFR
L
NS----
-
--
-
G
VPEYGQKGELRR
D
ER
N
L
MWN
V
DPYLQ
TQWQ
L
SE
K
L
S
L
D
AG
V
RY
SSVWFDSN
DH
------------
YVTP
GN
GDDSGDASYH
K
W
L
P
AGS
L
KYA
M
T
D
A
W
N
I
Y
L
A
AG
RG
FET
P
T
I
N
E
------
L
SYRAD
G
---
--
QS
G
M--
-
-----
-
-
N
F
G
LKP
S
T
N
D
T
I
EIG
SKTRIGD
GL
L
S
-
L
A
L
F
Q
TD
TD
DE
IV
V
-------
D
S
SSGGRTT
Y
K
N
A
GK
T
R
RQ
G
A
E
L
A
WDQ
R
-
FAG
D
FRVKA
S
W
TW
L
DATYRSN
VC
N
EQ
DC
---
N
G
N
----
R
MP
G
I
A
RN
M
G
F
A
S
I
G
Y
VPE
D
GWYAGTEA
R
YM
G
D
IM
A
D--
-
--
----
--
-----
D
EN
T
AKAPS
YTLVGL
FTG
Y
K
Y
N
Y
HNL
T
V
D
L
FGR
VDNLFDK
E
Y
VGSV
I
VNE
S
N
---
----
--
-----
-
-
G
R
---
Y
Y
E
PA
PGRNY
G
VG
M
N
fig|216592.3.peg.1640
Escherichia coli 042 (82-747/753)
MIVSA
TPQVVSE
L
DT
P
A
A
VSV
V
DG
EE
M
R
L
A
-
TPRI
N
LSE
S
L
T
S
-
VPG
L
Q
V
QNR
Q
NY
A
Q-
-
-
D
LQ
L
SIRG
F
G
SRS
T
YGIRGIRLYV
DG
I
P
ATMPDG
--
QG
QT
S
N
I
D
L-
-
----
-
-
---
--
-
SS
VQNV
EVLRGP
F
SALYGN
-
A
S
GGV
M
N
V
IT
Q
T
G
Q
QPPTIEASSYYGSF
GS
W
RY
G
LK
A
TG
A
MG
D
GT
Q
P
---
G
DVDY
TV
S
TT
R
F
TTH
G
--
-
-
-
---Y
R
DH
S
GAQ
K
NL
A
N
A
-------
KLGVRIDDASK
L
S
L
IFNS
V
DIK
A
D
D
P
GG
LT
E
A
E
WK
A
NPQQ
A
P
RA
E
QYD
T
R
K
-----
TIK
Q
TQ
A
G
L
R
Y
ER
SL
SAQ
-----------------
D
D
M
S
V
M
M
Y
A
-------------
-
-
GERETTQ
Y
QS
I
P
M
----
APQL
N
PSHAGGVIT
L
Q
R
---
HYQ
G
I
D
-
---
-------
-
----
----
S
RWTHR
G
EL
GV
P
L
------
T
F
T
T
G
L
N
Y
ENM
S
EN
R
KGYNNFR
L
NS----
-
--
-
G
VPEYGQKGELRR
D
ER
N
L
MWN
V
DPYLQ
TQWQ
L
SE
K
L
S
L
D
AG
V
RY
SSVWFDSN
DH
------------
YVTP
GN
GDDSGDASYH
K
W
L
P
AGS
L
KYA
M
T
D
A
W
N
I
Y
L
A
AG
RG
FET
P
T
I
N
E
------
L
SYRAD
G
---
--
QS
G
M--
-
-----
-
-
N
F
G
LKP
S
T
N
D
T
I
EIG
SKTRIGD
GL
L
S
-
L
A
L
F
Q
TD
TD
DE
IV
V
-------
D
S
SSGGRTT
Y
K
N
A
GK
T
R
RQ
G
A
E
L
A
WDQ
R
-
FAG
D
FRVKA
S
W
TW
L
DATYRSN
VC
N
EQ
DC
---
N
G
N
----
R
MP
G
I
A
RN
M
G
F
A
S
I
G
Y
VPE
D
GWYAGTEA
R
YM
G
D
IM
A
D--
-
--
----
--
-----
D
EN
T
AKAPS
YTLVGL
FTG
Y
K
Y
N
Y
HNL
T
V
D
L
FGR
VDNLFDK
E
Y
VGSV
I
VNE
S
N
---
----
--
-----
-
-
G
R
---
Y
Y
E
PA
PGRNY
G
VG
M
N
fig|656437.3.peg.1665
Escherichia coli TA143 (29-694/700)
MIVSA
TPQVVSE
L
DT
P
A
A
VSV
V
DG
EE
M
R
L
A
-
TPRI
N
LSE
S
L
T
S
-
VPG
L
Q
V
QNR
Q
NY
A
Q-
-
-
D
LQ
L
SIRG
F
G
SRS
T
YGIRGIRLYV
DG
I
P
ATMPDG
--
QG
QT
S
N
I
D
L-
-
----
-
-
---
--
-
SS
VQNV
EVLRGP
F
SALYGN
-
A
S
GGV
M
N
V
IT
Q
T
G
Q
QPPTIEASSYYGSF
GS
W
RY
G
LK
A
TG
A
MG
D
GT
Q
P
---
G
DVDY
TV
S
TT
R
F
TTH
G
--
-
-
-
---Y
R
DH
S
GAQ
K
NL
A
N
A
-------
KLGVRIDDASK
L
S
L
IFNS
V
DIK
A
D
D
P
GG
LT
E
A
E
WK
A
NPQQ
A
P
RA
E
QYD
T
R
K
-----
TIK
Q
TQ
A
G
L
R
Y
ER
SL
SAQ
-----------------
D
D
M
S
V
M
M
Y
A
-------------
-
-
GERETTQ
Y
QS
I
P
M
----
APQL
N
PSHAGGVIT
L
Q
R
---
HYQ
G
I
D
-
---
-------
-
----
----
S
RWTHR
G
EL
GV
P
L
------
T
F
T
T
G
L
N
Y
ENM
S
EN
R
KGYNNFR
L
NS----
-
--
-
G
VPEYGQKGELRR
D
ER
N
L
MWN
V
DPYLQ
TQWQ
L
SE
K
L
S
L
D
AG
V
RY
SSVWFDSN
DH
------------
YVTP
GN
GDDSGDASYH
K
W
L
P
AGS
L
KYA
M
T
D
A
W
N
I
Y
L
A
AG
RG
FET
P
T
I
N
E
------
L
SYRAD
G
---
--
QS
G
M--
-
-----
-
-
N
F
G
LKP
S
T
N
D
T
I
EIG
SKTRIGD
GL
L
S
-
L
A
L
F
Q
TD
TD
DE
IV
V
-------
D
S
SSGGRTT
Y
K
N
A
GK
T
R
RQ
G
A
E
L
A
WDQ
R
-
FAG
D
FRVKA
S
W
TW
L
DATYRSN
VC
N
EQ
DC
---
N
G
N
----
R
MP
G
I
A
RN
M
G
F
A
S
I
G
Y
VPE
D
GWYAGTEA
R
YM
G
D
IM
A
D--
-
--
----
--
-----
D
EN
T
AKAPS
YTLVGL
FTG
Y
K
Y
N
Y
HNL
T
V
D
L
FGR
VDNLFDK
E
Y
VGSV
I
VNE
S
N
---
----
--
-----
-
-
G
R
---
Y
Y
E
PA
PGRNY
G
VG
M
N
fig|656417.3.peg.1719
Escherichia coli M605 (29-694/700)
MIVSA
APQVVSE
L
DT
P
A
A
VSV
V
DG
EE
M
R
L
A
-
TPRI
N
LSE
S
L
T
G
-
VPG
L
Q
V
QNR
Q
NY
A
Q-
-
-
D
LQ
L
SIRG
F
G
SRS
T
YGIRGIRLYV
DG
I
P
ATMPDG
--
QG
QT
S
N
I
D
L-
-
----
-
-
---
--
-
SS
VQNV
EVLRGP
F
SALYGN
-
A
S
GGV
M
N
VT
T
Q
T
G
Q
QPPTIEASSYYGSF
GS
W
RY
G
LK
A
TG
A
TG
D
GT
Q
P
---
G
DVDY
TV
A
TT
R
F
TTH
G
--
-
-
-
---Y
R
DH
S
GAQ
K
NL
A
N
A
-------
KLGVRIDDASK
L
S
L
IFNS
V
DIK
A
D
D
P
GG
LT
E
A
E
WK
A
NPQQ
A
P
RA
E
QYD
M
R
K
-----
TIK
Q
TQ
A
G
L
R
Y
ER
SL
SAQ
-----------------
D
D
M
S
V
M
M
Y
A
-------------
-
-
GERETTQ
Y
QS
I
P
M
----
APQL
N
PSHAGGVIT
L
Q
R
---
HYQ
G
I
D
-
---
-------
-
----
----
S
RWTHR
G
EL
GV
P
V
------
T
F
T
T
G
L
N
Y
ENM
S
EN
R
KGYNNFR
L
NR----
-
--
-
G
VPEYGQKGELRR
D
ER
N
L
MWN
V
DPYLQ
TQWQ
LTD
K
L
S
L
D
AG
V
RY
SSVWFDSN
DH
------------
YVTP
GN
GDDSGDASYH
K
W
L
P
AGS
L
KYA
M
T
D
A
W
N
V
Y
L
A
AG
RG
FET
P
T
I
N
E
------
L
SYRAD
G
---
--
QS
G
M--
-
-----
-
-
N
F
G
LKP
S
T
N
D
T
I
EIG
SKTRIGD
GL
L
S
-
L
A
L
F
Q
TD
TD
DE
IV
V
-------
D
S
SSGGRTT
Y
K
N
A
GK
T
R
RQ
G
A
E
L
A
WDQ
R
-
FAG
D
FRVKA
S
W
TW
L
DATYRSN
VC
N
E
K
DC
---
N
G
N
----
R
MP
G
I
A
RN
M
G
F
A
S
I
G
Y
IPE
D
GWYAGTEA
R
YM
G
D
IM
A
D--
-
--
----
--
-----
D
EN
T
AKAPS
YTLVGL
FTG
Y
K
Y
N
Y
HNL
T
V
D
L
FGR
VDNLFDK
E
Y
VGSV
I
VNE
S
N
---
----
--
-----
-
-
G
R
---
Y
Y
E
PA
PGRNY
G
VG
I
N
fig|679205.4.peg.4668
Escherichia coli MS 124-1 (29-694/700)
MIVSA
APQVVSE
L
DT
P
A
A
VSV
V
DG
EE
M
R
L
A
-
TPRI
N
LSE
S
L
T
S
-
VPG
L
Q
V
QNR
Q
NY
A
Q-
-
-
D
LQ
L
SIRG
F
G
SRS
T
YGIRGIRLYV
DG
I
P
ATMPDG
--
QG
QT
S
N
I
D
L-
-
----
-
-
---
--
-
SS
VQNV
EVLRGP
F
SALYGN
-
A
S
GGV
M
N
VT
T
Q
T
G
Q
QPPTIEASSYYGSF
GS
W
RY
G
LK
A
TG
A
TG
D
GT
Q
P
---
G
DVDY
TV
S
TT
R
F
TTH
G
--
-
-
-
---Y
R
DH
S
GAQ
K
NL
A
N
A
-------
KLGVRIDEASK
L
S
L
IFNS
V
DIK
A
D
D
P
GG
LT
KA
E
WK
A
NPQQ
A
P
RA
E
QYD
T
R
K
-----
TIK
Q
TQ
A
G
L
R
Y
ER
SL
SAQ
-----------------
D
D
M
S
V
M
M
Y
A
-------------
-
-
GERETTQ
Y
QS
I
P
M
----
APQL
N
PSHAGGVIT
L
Q
R
---
HYQ
G
I
D
-
---
-------
-
----
----
S
RWTHR
G
EL
GV
P
V
------
T
F
T
T
G
L
N
Y
ENM
S
EN
R
KGYNNFR
L
NS----
-
--
-
G
MPEYGQKGELRR
D
ER
N
L
MWN
I
DPYLQ
TQWQ
L
SE
K
L
S
L
D
AG
V
RY
SSVWFDSN
DH
------------
YVTP
GN
GDDSGDASYH
K
W
L
P
AGS
L
KYA
M
T
D
A
W
N
I
Y
L
A
AG
RG
FET
P
T
I
N
E
------
L
SYRAD
G
---
--
QS
G
M--
-
-----
-
-
N
L
G
LKP
S
T
N
D
T
I
EIG
SKTRIGD
GL
L
S
-
L
A
L
F
Q
TD
TD
DE
IV
V
-------
D
S
SSGGRTT
Y
K
N
A
GK
T
R
RQ
G
A
E
L
A
WDQ
R
-
FAG
D
FRVNA
S
W
TW
L
DATYRSN
VC
N
EQ
DC
---
N
G
N
----
R
MP
G
I
A
RN
M
G
F
A
S
I
G
Y
VPE
D
GWYAGTEA
R
YM
G
D
IM
A
D--
-
--
----
--
-----
D
EN
T
AKAPS
YTLVGL
FTG
Y
K
Y
N
Y
HNL
T
V
D
L
FGR
VDNLFDK
E
Y
VGSV
I
VNE
S
N
---
----
--
-----
-
-
G
R
---
Y
Y
E
PS
PGRNY
G
VG
M
N
fig|749533.3.peg.80
Escherichia coli MS 84-1 (29-694/700)
MIVSA
APQVVSE
L
DT
P
A
A
VSV
V
DG
EE
M
R
L
A
-
TPRI
N
LSE
S
L
T
S
-
VPG
L
Q
V
QNR
Q
NY
A
Q-
-
-
D
LQ
L
SIRG
F
G
SRS
T
YGIRGIRLYV
DG
I
P
ATMPDG
--
QG
QT
S
N
I
D
L-
-
----
-
-
---
--
-
SS
VQNV
EVLRGP
F
SALYGN
-
A
S
GGV
M
N
VT
T
Q
T
G
Q
QPPTIEASSYYGSF
GS
W
RY
G
LK
A
TG
A
TG
D
GT
Q
P
---
G
DVDY
TV
S
TT
R
F
TTH
G
--
-
-
-
---Y
R
DH
S
GAQ
K
NL
A
N
A
-------
KLGVRIDEASK
L
S
L
IFNS
V
DIK
A
D
D
P
GG
LT
KA
E
WK
A
NPQQ
A
P
RA
E
QYD
T
R
K
-----
TIK
Q
TQ
A
G
L
R
Y
ER
SL
SAQ
-----------------
D
D
M
S
V
M
M
Y
A
-------------
-
-
GERETTQ
Y
QS
I
P
M
----
APQL
N
PSHAGGVIT
L
Q
R
---
HYQ
G
I
D
-
---
-------
-
----
----
S
RWTHR
G
EL
GV
P
V
------
T
F
T
T
G
L
N
Y
ENM
S
EN
R
KGYNNFR
L
NS----
-
--
-
G
MPEYGQKGELRR
D
ER
N
L
MWN
I
DPYLQ
TQWQ
L
SE
K
L
S
L
D
AG
V
RY
SSVWFDSN
DH
------------
YVTP
GN
GDDSGDASYH
K
W
L
P
AGS
L
KYA
M
T
D
A
W
N
I
Y
L
A
AG
RG
FET
P
T
I
N
E
------
L
SYRAD
G
---
--
QS
G
M--
-
-----
-
-
N
L
G
LKP
S
T
N
D
T
I
EIG
SKTRIGD
GL
L
S
-
L
A
L
F
Q
TD
TD
DE
IV
V
-------
D
S
SSGGRTT
Y
K
N
A
GK
T
R
RQ
G
A
E
L
A
WDQ
R
-
FAG
D
FRVNA
S
W
TW
L
DATYRSN
VC
N
EQ
DC
---
N
G
N
----
R
MP
G
I
A
RN
M
G
F
A
S
I
G
Y
VPE
D
GWYAGTEA
R
YM
G
D
IM
A
D--
-
--
----
--
-----
D
EN
T
AKAPS
YTLVGL
FTG
Y
K
Y
N
Y
HNL
T
V
D
L
FGR
VDNLFDK
E
Y
VGSV
I
VNE
S
N
---
----
--
-----
-
-
G
R
---
Y
Y
E
PS
PGRNY
G
VG
M
N
fig|585397.7.peg.1618
Escherichia coli ED1a (29-694/700)
MIVSA
APQVVSE
L
DT
P
A
A
VSV
V
NG
EE
M
R
L
A
-
TPRI
N
LSE
S
L
T
G
-
VPG
L
Q
V
QNR
Q
NY
A
Q-
-
-
D
LQ
L
SIRG
F
G
SRS
T
YGIRGIRLYV
DG
I
P
ATMPDG
--
QG
QT
S
N
I
D
L-
-
----
-
-
---
--
-
SS
VQNV
EVLRGP
F
SALYGN
-
A
S
GGV
M
N
VT
T
Q
T
G
Q
QPPTIEASSYYGSF
GS
W
RY
G
LK
A
TG
A
TG
D
GT
Q
P
---
G
DVDY
TV
S
TT
R
F
TTH
G
--
-
-
-
---Y
R
DH
S
GAQ
K
NL
A
N
A
-------
KLGVRIDDASK
L
S
L
IFNS
V
DIK
A
D
D
P
GG
LT
KA
E
WK
A
NPQQ
A
P
RA
E
QYD
T
R
K
-----
TIK
Q
TQ
A
G
L
R
Y
ER
SL
SAQ
-----------------
D
D
M
S
V
M
M
Y
A
-------------
-
-
GERETTQ
Y
QS
I
P
M
----
APQL
N
PSHAGGVIT
L
Q
R
---
HYQ
G
I
D
-
---
-------
-
----
----
S
RWTHR
G
EL
GV
P
L
------
T
F
T
T
G
L
N
Y
ENM
S
EN
R
KGYNNFR
L
NS----
-
--
-
G
VPEYGQKGELRR
D
ER
N
L
MWN
V
DPYLQ
TQWQ
L
SE
K
L
S
L
D
AG
V
RY
SSVWFDSN
DH
------------
YVTP
GN
GDDSGDASYH
K
W
L
P
AGS
L
KYA
M
T
D
A
W
N
I
Y
L
A
AG
RG
FET
P
T
I
N
E
------
L
SYRAD
G
---
--
QS
G
M--
-
-----
-
-
N
F
G
LKP
S
T
N
D
T
I
EIG
SKTRIGD
GL
L
S
-
L
A
L
F
Q
TD
TD
DE
IV
V
-------
D
S
SSGGRTT
Y
K
N
A
GK
T
R
RQ
G
A
E
L
A
WDQ
R
-
FAG
D
FRVKA
S
W
TW
L
DATYRSN
VC
N
EQ
DC
---
N
G
N
----
R
MP
G
I
A
RN
M
G
F
A
S
I
G
Y
IPE
D
GWYAGTEA
R
YM
G
D
IM
A
D--
-
--
----
--
-----
D
EN
T
AKAPS
YTLVGL
FTG
Y
K
Y
N
Y
HN
F
T
V
D
L
FGR
VDNLFDK
E
Y
VGSV
I
VNE
S
N
---
----
--
-----
-
-
G
R
---
Y
Y
E
PA
PGRNY
G
VG
I
N
fig|585397.9.peg.1611
Escherichia coli ED1a (29-694/700)
MIVSA
APQVVSE
L
DT
P
A
A
VSV
V
NG
EE
M
R
L
A
-
TPRI
N
LSE
S
L
T
G
-
VPG
L
Q
V
QNR
Q
NY
A
Q-
-
-
D
LQ
L
SIRG
F
G
SRS
T
YGIRGIRLYV
DG
I
P
ATMPDG
--
QG
QT
S
N
I
D
L-
-
----
-
-
---
--
-
SS
VQNV
EVLRGP
F
SALYGN
-
A
S
GGV
M
N
VT
T
Q
T
G
Q
QPPTIEASSYYGSF
GS
W
RY
G
LK
A
TG
A
TG
D
GT
Q
P
---
G
DVDY
TV
S
TT
R
F
TTH
G
--
-
-
-
---Y
R
DH
S
GAQ
K
NL
A
N
A
-------
KLGVRIDDASK
L
S
L
IFNS
V
DIK
A
D
D
P
GG
LT
KA
E
WK
A
NPQQ
A
P
RA
E
QYD
T
R
K
-----
TIK
Q
TQ
A
G
L
R
Y
ER
SL
SAQ
-----------------
D
D
M
S
V
M
M
Y
A
-------------
-
-
GERETTQ
Y
QS
I
P
M
----
APQL
N
PSHAGGVIT
L
Q
R
---
HYQ
G
I
D
-
---
-------
-
----
----
S
RWTHR
G
EL
GV
P
L
------
T
F
T
T
G
L
N
Y
ENM
S
EN
R
KGYNNFR
L
NS----
-
--
-
G
VPEYGQKGELRR
D
ER
N
L
MWN
V
DPYLQ
TQWQ
L
SE
K
L
S
L
D
AG
V
RY
SSVWFDSN
DH
------------
YVTP
GN
GDDSGDASYH
K
W
L
P
AGS
L
KYA
M
T
D
A
W
N
I
Y
L
A
AG
RG
FET
P
T
I
N
E
------
L
SYRAD
G
---
--
QS
G
M--
-
-----
-
-
N
F
G
LKP
S
T
N
D
T
I
EIG
SKTRIGD
GL
L
S
-
L
A
L
F
Q
TD
TD
DE
IV
V
-------
D
S
SSGGRTT
Y
K
N
A
GK
T
R
RQ
G
A
E
L
A
WDQ
R
-
FAG
D
FRVKA
S
W
TW
L
DATYRSN
VC
N
EQ
DC
---
N
G
N
----
R
MP
G
I
A
RN
M
G
F
A
S
I
G
Y
IPE
D
GWYAGTEA
R
YM
G
D
IM
A
D--
-
--
----
--
-----
D
EN
T
AKAPS
YTLVGL
FTG
Y
K
Y
N
Y
HN
F
T
V
D
L
FGR
VDNLFDK
E
Y
VGSV
I
VNE
S
N
---
----
--
-----
-
-
G
R
---
Y
Y
E
PA
PGRNY
G
VG
I
N
fig|749546.3.peg.802
Escherichia coli MS 185-1 (29-694/700)
MIVSA
APQVVSE
L
DT
P
A
A
VSV
V
NG
EE
M
R
L
A
-
TPRI
N
LSE
S
L
T
G
-
VPG
L
Q
V
QNR
Q
NY
A
Q-
-
-
D
LQ
L
SIRG
F
G
SRS
T
YGIRGIRLYV
DG
I
P
ATMPDG
--
QG
QT
S
N
I
D
L-
-
----
-
-
---
--
-
SS
VQNV
EVLRGP
F
SALYGN
-
A
S
GGV
M
N
VT
T
Q
T
G
Q
QPPTIEASSYYGSF
GS
W
RY
G
LK
A
TG
A
TG
D
GT
Q
P
---
G
DVDY
TV
S
TT
R
F
TTH
G
--
-
-
-
---Y
R
DH
S
GAQ
K
NL
A
N
A
-------
KLGVRIDDASK
L
S
L
IFNS
V
DIK
A
D
D
P
GG
LT
KA
E
WK
A
NPQQ
A
P
RA
E
QYD
T
R
K
-----
TIK
Q
TQ
A
G
L
R
Y
ER
SL
SAQ
-----------------
D
D
M
S
V
M
M
Y
A
-------------
-
-
GERETTQ
Y
QS
I
P
M
----
APQL
N
PSHAGGVIT
L
Q
R
---
HYQ
G
I
D
-
---
-------
-
----
----
S
RWTHR
G
EL
GV
P
L
------
T
F
T
T
G
L
N
Y
ENM
S
EN
R
KGYNNFR
L
NS----
-
--
-
G
VPEYGQKGELRR
D
ER
N
L
MWN
V
DPYLQ
TQWQ
L
SE
K
L
S
L
D
AG
V
RY
SSVWFDSN
DH
------------
YVTP
GN
GDDSGDASYH
K
W
L
P
AGS
L
KYA
M
T
D
A
W
N
I
Y
L
A
AG
RG
FET
P
T
I
N
E
------
L
SYRAD
G
---
--
QS
G
M--
-
-----
-
-
N
F
G
LKP
S
T
N
D
T
I
EIG
SKTRIGD
GL
L
S
-
L
A
L
F
Q
TD
TD
DE
IV
V
-------
D
S
SSGGRTT
Y
K
N
A
GK
T
R
RQ
G
A
E
L
A
WDQ
R
-
FAG
D
FRVKA
S
W
TW
L
DATYRSN
VC
N
EQ
DC
---
N
G
N
----
R
MP
G
I
A
RN
M
G
F
A
S
I
G
Y
IPE
D
GWYAGTEA
R
YM
G
D
IM
A
D--
-
--
----
--
-----
D
EN
T
AKAPS
YTLVGL
FTG
Y
K
Y
N
Y
HN
F
T
V
D
L
FGR
VDNLFDK
E
Y
VGSV
I
VNE
S
N
---
----
--
-----
-
-
G
R
---
Y
Y
E
PA
PGRNY
G
VG
I
N
fig|749528.3.peg.1200
Escherichia coli MS 45-1 (29-694/700)
MIVSA
APQVVSE
L
DT
P
A
A
VSV
V
NG
EE
M
R
L
A
-
TPRI
N
LSE
S
L
T
G
-
VPG
L
Q
V
QNR
Q
NY
A
Q-
-
-
D
LQ
L
SIRG
F
G
SRS
T
YGIRGIRLYV
DG
I
P
ATMPDG
--
QG
QT
S
N
I
D
L-
-
----
-
-
---
--
-
SS
VQNV
EVLRGP
F
SALYGN
-
A
S
GGV
M
N
VT
T
Q
T
G
Q
QPPTIEASSYYGSF
GS
W
RY
G
LK
A
TG
A
TG
D
GT
Q
P
---
G
DVDY
TV
S
TT
R
F
TTH
G
--
-
-
-
---Y
R
DH
S
GAQ
K
NL
A
N
A
-------
KLGVRIDDASK
L
S
L
IFNS
V
DIK
A
D
D
P
GG
LT
KA
E
WK
A
NPQQ
A
P
RA
E
QYD
T
R
K
-----
TIK
Q
TQ
A
G
L
R
Y
ER
SL
SAQ
-----------------
D
D
M
S
V
M
M
Y
A
-------------
-
-
GERETTQ
Y
QS
I
P
M
----
APQL
N
PSHAGGVIT
L
Q
R
---
HYQ
G
I
D
-
---
-------
-
----
----
S
RWTHR
G
EL
GV
P
L
------
T
F
T
T
G
L
N
Y
ENM
S
EN
R
KGYNNFR
L
NS----
-
--
-
G
VPEYGQKGELRR
D
ER
N
L
MWN
V
DPYLQ
TQWQ
L
SE
K
L
S
L
D
AG
V
RY
SSVWFDSN
DH
------------
YVTP
GN
GDDSGDASYH
K
W
L
P
AGS
L
KYA
M
T
D
A
W
N
I
Y
L
A
AG
RG
FET
P
T
I
N
E
------
L
SYRAD
G
---
--
QS
G
M--
-
-----
-
-
N
F
G
LKP
S
T
N
D
T
I
EIG
SKTRIGD
GL
L
S
-
L
A
L
F
Q
TD
TD
DE
IV
V
-------
D
S
SSGGRTT
Y
K
N
A
GK
T
R
RQ
G
A
E
L
A
WDQ
R
-
FAG
D
FRVKA
S
W
TW
L
DATYRSN
VC
N
EQ
DC
---
N
G
N
----
R
MP
G
I
A
RN
M
G
F
A
S
I
G
Y
IPE
D
GWYAGTEA
R
YM
G
D
IM
A
D--
-
--
----
--
-----
D
EN
T
AKAPS
YTLVGL
FTG
Y
K
Y
N
Y
HN
F
T
V
D
L
FGR
VDNLFDK
E
Y
VGSV
I
VNE
S
N
---
----
--
-----
-
-
G
R
---
Y
Y
E
PA
PGRNY
G
VG
I
N
fig|753642.3.peg.1711
Escherichia coli NC101 (29-694/700)
MIVSA
APQVVSE
L
DT
P
A
A
VSV
V
DG
EE
M
R
L
A
-
TPRI
N
LSE
S
L
T
G
-
VPG
L
Q
V
QNR
Q
NY
A
Q-
-
-
D
LQ
L
SIRG
F
G
SRS
T
YGIRGIRLYV
DG
I
P
ATMPDG
--
QG
QT
S
N
I
D
L-
-
----
-
-
---
--
-
SS
VQNV
EVLRGP
F
SALYGN
-
A
S
GGV
M
N
VT
T
Q
T
G
Q
QPPTIEASSYYGSF
GS
W
RY
G
LK
A
TG
A
TG
D
GT
Q
P
---
G
DVDY
TV
S
TT
R
F
TTH
G
--
-
-
-
---Y
R
DH
S
GAQ
K
NL
A
N
A
-------
KLGVRIDDASK
L
S
L
IFNS
V
DIK
A
D
D
P
GG
LT
KA
E
WK
A
NPQQ
A
P
RA
E
QYD
T
R
K
-----
TIK
Q
TQ
A
G
L
R
Y
ER
SL
SAQ
-----------------
D
D
M
S
V
M
M
Y
A
-------------
-
-
GERETTQ
Y
QS
I
P
M
----
APQL
N
PSHAGGVIT
L
Q
R
---
HYQ
G
I
D
-
---
-------
-
----
----
S
RWTHR
G
EL
GV
P
L
------
T
F
T
T
G
L
N
Y
ENM
S
EN
R
KGYNNFR
L
NS----
-
--
-
G
VPEYGQKGELRR
D
ER
N
L
MWN
V
DPYLQ
TQWQ
L
SE
K
L
S
L
D
AG
V
RY
SSVWFDSN
DH
------------
YVTP
GN
GDDSGDASYH
K
W
L
P
AGS
L
KYA
M
T
D
A
W
N
I
Y
L
A
AG
RG
FET
P
T
I
N
E
------
L
SYRAD
G
---
--
QS
G
M--
-
-----
-
-
N
F
G
LKP
S
T
N
D
T
I
EIG
SKTRIGD
GL
L
S
-
L
A
L
F
Q
TD
TD
DE
IV
V
-------
D
S
SSGGRTT
Y
K
N
A
GK
T
R
RQ
G
A
E
L
A
WDQ
R
-
FAG
D
FRVKA
S
W
TW
L
DATYRSN
VC
N
EQ
DC
---
N
G
N
----
R
MP
G
I
A
RN
M
G
F
A
S
I
G
Y
IPE
D
GWYAGTEA
R
YM
G
D
IM
A
D--
-
--
----
--
-----
D
EN
T
AKAPS
YTLVGL
FTG
Y
K
Y
N
Y
HN
F
T
V
D
L
FGR
VDNLFDK
E
Y
VGSV
I
VNE
S
N
---
----
--
-----
-
-
G
R
---
Y
Y
E
PA
PGRNY
G
VG
I
N
fig|685038.3.peg.1443
Escherichia coli O83:H1 str. NRG 857C (29-694/700)
MIVSA
APQVVSE
L
DT
P
A
A
VSV
V
DG
EE
M
R
L
A
-
TPRI
N
LSE
S
L
T
G
-
VPG
L
Q
V
QNR
Q
NY
A
Q-
-
-
D
LQ
L
SIRG
F
G
SRS
T
YGIRGIRLYV
DG
I
P
ATMPDG
--
QG
QT
S
N
I
D
L-
-
----
-
-
---
--
-
SS
VQNV
EVLRGP
F
SALYGN
-
A
S
GGV
M
N
VT
T
Q
T
G
Q
QPPTIEASSYYGSF
GS
W
RY
G
LK
A
TG
A
TG
D
GT
Q
P
---
G
DVDY
TV
S
TT
R
F
TTH
G
--
-
-
-
---Y
R
DH
S
GAQ
K
NL
A
N
A
-------
KLGVRIDDASK
L
S
L
IFNS
V
DIK
A
D
D
P
GG
LT
KA
E
WK
A
NPQQ
A
P
RA
E
QYD
T
R
K
-----
TIK
Q
TQ
A
G
L
R
Y
ER
SL
SAQ
-----------------
D
D
M
S
V
M
M
Y
A
-------------
-
-
GERETTQ
Y
QS
I
P
M
----
APQL
N
PSHAGGVIT
L
Q
R
---
HYQ
G
I
D
-
---
-------
-
----
----
S
RWTHR
G
EL
GV
P
L
------
T
F
T
T
G
L
N
Y
ENM
S
EN
R
KGYNNFR
L
NS----
-
--
-
G
VPEYGQKGELRR
D
ER
N
L
MWN
V
DPYLQ
TQWQ
L
SE
K
L
S
L
D
AG
V
RY
SSVWFDSN
DH
------------
YVTP
GN
GDDSGDASYH
K
W
L
P
AGS
L
KYA
M
T
D
A
W
N
I
Y
L
A
AG
RG
FET
P
T
I
N
E
------
L
SYRAD
G
---
--
QS
G
M--
-
-----
-
-
N
F
G
LKP
S
T
N
D
T
I
EIG
SKTRIGD
GL
L
S
-
L
A
L
F
Q
TD
TD
DE
IV
V
-------
D
S
SSGGRTT
Y
K
N
A
GK
T
R
RQ
G
A
E
L
A
WDQ
R
-
FAG
D
FRVKA
S
W
TW
L
DATYRSN
VC
N
EQ
DC
---
N
G
N
----
R
MP
G
I
A
RN
M
G
F
A
S
I
G
Y
IPE
D
GWYAGTEA
R
YM
G
D
IM
A
D--
-
--
----
--
-----
D
EN
T
AKAPS
YTLVGL
FTG
Y
K
Y
N
Y
HN
F
T
V
D
L
FGR
VDNLFDK
E
Y
VGSV
I
VNE
S
N
---
----
--
-----
-
-
G
R
---
Y
Y
E
PA
PGRNY
G
VG
I
N
fig|550676.3.peg.1020
Escherichia coli B185 (1-666/672)
MIVSA
APQVVSE
L
DT
P
A
A
VSV
V
DG
EE
M
R
L
A
-
TPRI
N
LSE
S
L
T
G
-
VPG
L
Q
V
QNR
Q
NY
A
Q-
-
-
D
LQ
L
SIRG
F
G
SRS
T
YGIRGIRLYV
DG
I
P
ATMPDG
--
QG
QT
S
N
I
D
L-
-
----
-
-
---
--
-
SS
VQNV
EVLRGP
F
SALYGN
-
A
S
GGV
M
N
VT
T
Q
T
G
Q
QPPTIEASSYYGSF
GS
W
RY
G
LK
A
TG
A
TG
D
GT
Q
S
---
G
DVDY
TV
S
TT
R
F
TTH
G
--
-
-
-
---Y
R
DH
S
GAQ
K
NL
A
N
A
-------
KLGVRIDEASK
L
S
L
IFNS
V
DIK
A
D
D
P
GG
LT
KA
E
WK
A
NPQQ
A
P
RA
E
QYD
T
R
K
-----
TIK
Q
TQ
A
G
L
R
Y
ER
SL
SSR
-----------------
D
D
M
S
V
M
M
Y
A
-------------
-
-
GERETTQ
Y
QS
I
P
M
----
APQL
N
PSHAGGVIT
L
Q
R
---
HYQ
G
I
D
-
---
-------
-
----
----
S
RWTHR
G
EL
GV
P
V
------
T
F
T
T
G
L
N
Y
ENM
S
EN
R
KGYNNFR
L
NS----
-
--
-
G
MPEYGQKGELRR
D
ER
N
L
MWN
I
DPYLQ
TQWQ
L
SE
K
L
S
L
D
AG
V
RY
SSVWFDSN
DH
------------
YITP
GN
GDDSGDASYH
K
W
L
P
AGS
L
KYA
M
T
D
A
W
N
I
Y
L
A
AG
RG
FET
P
T
I
N
E
------
L
SYRAD
G
---
--
QS
G
M--
-
-----
-
-
N
F
G
LKP
S
T
N
D
T
I
EIG
SKTRIGD
GL
L
S
-
L
A
L
F
Q
TD
TD
DE
IV
V
-------
D
S
SSGGRTT
Y
K
N
A
GK
T
R
RQ
G
A
E
L
A
WDQ
R
-
FAG
D
FRVNA
S
W
TW
L
DATYRSN
VC
N
EQ
DC
---
N
G
N
----
R
MP
G
I
A
RN
M
G
F
A
S
I
G
Y
VPE
D
GWYAGTEA
R
YM
G
D
IM
A
D--
-
--
----
--
-----
D
EN
T
AKAPS
YTLVGL
FTG
Y
K
Y
N
Y
HNL
T
V
D
L
FGR
VDNLFDK
E
Y
VSSV
I
VNE
S
N
---
----
--
-----
-
-
G
R
---
Y
Y
E
PA
PGRNY
G
VG
VN
fig|595495.4.peg.4823
Escherichia coli KO11 (29-694/700)
MIVSA
APQVVSE
L
DT
P
A
A
VSV
V
DG
EE
M
R
L
A
-
TPRI
N
LSE
S
L
T
G
-
VPG
L
Q
V
QNR
Q
NY
A
Q-
-
-
D
LQ
L
SIRG
F
G
SRS
T
YGIRGIRLY
M
DG
I
P
ATMPDG
--
QG
QT
S
N
I
D
L-
-
----
-
-
---
--
-
SS
VQNV
EVLRGP
F
SALYGN
-
A
S
GGV
M
N
VT
T
Q
T
G
Q
QPPTIEASSYYGSF
GS
W
RY
G
LK
A
TG
A
TG
D
GT
Q
P
---
G
DVDY
TV
S
TT
R
F
TTH
G
--
-
-
-
---Y
R
DH
S
GAQ
K
NL
A
N
A
-------
KLGVRIDEASK
L
S
L
IFNS
V
DIK
A
D
D
P
GG
LT
KA
E
WK
A
NPQQ
A
P
RA
E
QYD
T
R
K
-----
TIK
Q
TQ
A
G
L
R
Y
ER
SL
SAQ
-----------------
D
D
M
S
V
M
M
Y
A
-------------
-
-
GERETTQ
Y
QS
I
P
M
----
APQL
N
PSHAGGVIT
L
Q
R
---
HYQ
G
I
D
-
---
-------
-
----
----
S
RWTHR
G
EL
GV
P
V
------
T
F
T
T
G
L
N
Y
ENM
S
EN
R
KGYNNFR
L
NS----
-
--
-
G
MPEYGQKGELRR
D
ER
N
L
MWN
I
DPYLQ
TQWQ
L
SE
K
L
S
L
D
AG
V
RY
SSVWFDSN
DH
------------
YVTP
GN
GDDSGDASYH
K
W
L
P
AGS
L
KYA
M
T
D
A
W
N
I
Y
L
A
AG
RG
FET
P
T
I
N
E
------
L
SYRAD
G
---
--
QS
G
M--
-
-----
-
-
N
L
G
LKP
S
T
N
D
T
I
EIG
SKTRIGD
GL
L
S
-
L
A
L
F
Q
TD
TD
DE
IV
V
-------
D
S
SSGGRTT
Y
K
N
A
GK
T
R
RQ
G
A
E
L
A
WDQ
R
-
FAG
D
FRVNA
S
W
TW
L
DATYRSN
VC
N
EQ
DC
---
N
G
N
----
R
MP
G
I
A
RN
M
G
F
A
S
I
G
Y
VPE
D
GWYAGTEA
R
YM
G
D
IM
A
D--
-
--
----
--
-----
D
EN
T
AKAPS
YTLVGL
FTG
Y
K
Y
N
Y
HNL
T
V
D
L
FGR
VDNLFDK
E
Y
VGSV
I
VNE
S
N
---
----
--
-----
-
-
G
R
---
Y
Y
E
PS
PGRNY
G
VG
M
N
fig|566546.3.peg.10
Escherichia coli W (29-694/700)
MIVSA
APQVVSE
L
DT
P
A
A
VSV
V
DG
EE
M
R
L
A
-
TPRI
N
LSE
S
L
T
G
-
VPG
L
Q
V
QNR
Q
NY
A
Q-
-
-
D
LQ
L
SIRG
F
G
SRS
T
YGIRGIRLY
M
DG
I
P
ATMPDG
--
QG
QT
S
N
I
D
L-
-
----
-
-
---
--
-
SS
VQNV
EVLRGP
F
SALYGN
-
A
S
GGV
M
N
VT
T
Q
T
G
Q
QPPTIEASSYYGSF
GS
W
RY
G
LK
A
TG
A
TG
D
GT
Q
P
---
G
DVDY
TV
S
TT
R
F
TTH
G
--
-
-
-
---Y
R
DH
S
GAQ
K
NL
A
N
A
-------
KLGVRIDEASK
L
S
L
IFNS
V
DIK
A
D
D
P
GG
LT
KA
E
WK
A
NPQQ
A
P
RA
E
QYD
T
R
K
-----
TIK
Q
TQ
A
G
L
R
Y
ER
SL
SAQ
-----------------
D
D
M
S
V
M
M
Y
A
-------------
-
-
GERETTQ
Y
QS
I
P
M
----
APQL
N
PSHAGGVIT
L
Q
R
---
HYQ
G
I
D
-
---
-------
-
----
----
S
RWTHR
G
EL
GV
P
V
------
T
F
T
T
G
L
N
Y
ENM
S
EN
R
KGYNNFR
L
NS----
-
--
-
G
MPEYGQKGELRR
D
ER
N
L
MWN
I
DPYLQ
TQWQ
L
SE
K
L
S
L
D
AG
V
RY
SSVWFDSN
DH
------------
YVTP
GN
GDDSGDASYH
K
W
L
P
AGS
L
KYA
M
T
D
A
W
N
I
Y
L
A
AG
RG
FET
P
T
I
N
E
------
L
SYRAD
G
---
--
QS
G
M--
-
-----
-
-
N
L
G
LKP
S
T
N
D
T
I
EIG
SKTRIGD
GL
L
S
-
L
A
L
F
Q
TD
TD
DE
IV
V
-------
D
S
SSGGRTT
Y
K
N
A
GK
T
R
RQ
G
A
E
L
A
WDQ
R
-
FAG
D
FRVNA
S
W
TW
L
DATYRSN
VC
N
EQ
DC
---
N
G
N
----
R
MP
G
I
A
RN
M
G
F
A
S
I
G
Y
VPE
D
GWYAGTEA
R
YM
G
D
IM
A
D--
-
--
----
--
-----
D
EN
T
AKAPS
YTLVGL
FTG
Y
K
Y
N
Y
HNL
T
V
D
L
FGR
VDNLFDK
E
Y
VGSV
I
VNE
S
N
---
----
--
-----
-
-
G
R
---
Y
Y
E
PS
PGRNY
G
VG
M
N
fig|566546.4.peg.1569
Escherichia coli W (29-694/700)
MIVSA
APQVVSE
L
DT
P
A
A
VSV
V
DG
EE
M
R
L
A
-
TPRI
N
LSE
S
L
T
G
-
VPG
L
Q
V
QNR
Q
NY
A
Q-
-
-
D
LQ
L
SIRG
F
G
SRS
T
YGIRGIRLY
M
DG
I
P
ATMPDG
--
QG
QT
S
N
I
D
L-
-
----
-
-
---
--
-
SS
VQNV
EVLRGP
F
SALYGN
-
A
S
GGV
M
N
VT
T
Q
T
G
Q
QPPTIEASSYYGSF
GS
W
RY
G
LK
A
TG
A
TG
D
GT
Q
P
---
G
DVDY
TV
S
TT
R
F
TTH
G
--
-
-
-
---Y
R
DH
S
GAQ
K
NL
A
N
A
-------
KLGVRIDEASK
L
S
L
IFNS
V
DIK
A
D
D
P
GG
LT
KA
E
WK
A
NPQQ
A
P
RA
E
QYD
T
R
K
-----
TIK
Q
TQ
A
G
L
R
Y
ER
SL
SAQ
-----------------
D
D
M
S
V
M
M
Y
A
-------------
-
-
GERETTQ
Y
QS
I
P
M
----
APQL
N
PSHAGGVIT
L
Q
R
---
HYQ
G
I
D
-
---
-------
-
----
----
S
RWTHR
G
EL
GV
P
V
------
T
F
T
T
G
L
N
Y
ENM
S
EN
R
KGYNNFR
L
NS----
-
--
-
G
MPEYGQKGELRR
D
ER
N
L
MWN
I
DPYLQ
TQWQ
L
SE
K
L
S
L
D
AG
V
RY
SSVWFDSN
DH
------------
YVTP
GN
GDDSGDASYH
K
W
L
P
AGS
L
KYA
M
T
D
A
W
N
I
Y
L
A
AG
RG
FET
P
T
I
N
E
------
L
SYRAD
G
---
--
QS
G
M--
-
-----
-
-
N
L
G
LKP
S
T
N
D
T
I
EIG
SKTRIGD
GL
L
S
-
L
A
L
F
Q
TD
TD
DE
IV
V
-------
D
S
SSGGRTT
Y
K
N
A
GK
T
R
RQ
G
A
E
L
A
WDQ
R
-
FAG
D
FRVNA
S
W
TW
L
DATYRSN
VC
N
EQ
DC
---
N
G
N
----
R
MP
G
I
A
RN
M
G
F
A
S
I
G
Y
VPE
D
GWYAGTEA
R
YM
G
D
IM
A
D--
-
--
----
--
-----
D
EN
T
AKAPS
YTLVGL
FTG
Y
K
Y
N
Y
HNL
T
V
D
L
FGR
VDNLFDK
E
Y
VGSV
I
VNE
S
N
---
----
--
-----
-
-
G
R
---
Y
Y
E
PS
PGRNY
G
VG
M
N
fig|562.375.peg.4338
Escherichia coli EC4100B (1-666/672)
MIVSA
APQVVSE
L
DT
P
A
A
VSV
V
DG
EE
M
R
L
A
-
TPRI
N
LSE
S
L
T
G
-
VPG
L
Q
V
QNR
Q
NY
A
Q-
-
-
D
LQ
L
SIRG
F
G
SRS
T
YGIRGIRLY
M
DG
I
P
ATMPDG
--
QG
QT
S
N
I
D
L-
-
----
-
-
---
--
-
SS
VQNV
EVLRGP
F
SALYGN
-
A
S
GGV
M
N
VT
T
Q
T
G
Q
QPPTIEASSYYGSF
GS
W
RY
G
LK
A
TG
A
TG
D
GT
Q
P
---
G
DVDY
TV
S
TT
R
F
TTH
G
--
-
-
-
---Y
R
DH
S
GAQ
K
NL
A
N
A
-------
KLGVRIDEASK
L
S
L
IFNS
V
DIK
A
D
D
P
GG
LT
KA
E
WK
A
NPQQ
A
P
RA
E
QYD
T
R
K
-----
TIK
Q
TQ
A
G
L
H
Y
ER
SL
SAQ
-----------------
D
D
M
S
V
M
M
Y
A
-------------
-
-
GERETTQ
Y
QS
I
P
M
----
APQL
N
PSHAGGVIT
L
Q
R
---
HYQ
G
V
D
-
---
-------
-
----
----
S
RWTHR
G
EL
GV
P
V
------
T
F
T
T
G
L
N
Y
ENM
S
EN
R
KGYNNFR
L
NS----
-
--
-
G
VPEYGQKGELRR
D
ER
N
L
MWN
V
DPYLQ
TQWQ
L
SE
K
L
S
L
D
AG
V
RY
SSVWFDSN
DH
------------
YVTP
GN
GDDSGDASYH
K
W
L
P
AGS
L
KYA
M
T
D
A
W
N
I
Y
L
A
AG
RG
FET
P
T
I
N
E
------
L
SYRAD
G
---
--
QS
G
M--
-
-----
-
-
N
F
G
LKP
S
T
N
D
T
I
EIG
SKTRIGD
GL
L
S
-
L
A
L
F
Q
TD
TD
DE
IV
V
-------
D
S
SSGGRTT
Y
K
N
A
GK
T
R
RQ
G
A
E
L
A
WDQ
R
-
FAG
D
FRVKA
S
W
TW
L
DATYRSN
VC
N
EQ
DC
---
N
G
N
----
R
MP
G
I
A
RN
M
G
F
A
S
I
G
Y
VPE
D
GWYAGTEA
R
YM
G
D
IM
A
D--
-
--
----
--
-----
D
EN
T
AKAPS
YTLVGL
FTG
Y
K
Y
N
Y
HNL
T
V
D
L
FGR
VDNLFDK
E
Y
VGSV
I
VNE
S
N
---
----
--
-----
-
-
G
R
---
Y
Y
E
PS
PGRNY
G
VG
M
N
fig|595496.3.peg.1406
Escherichia coli BW2952 (29-694/700)
MIVSA
APQVVSE
L
DT
P
A
A
VSV
V
DG
EE
M
R
L
A
-
TPRI
N
LSE
S
L
T
G
-
VPG
L
Q
V
QNR
Q
NY
A
Q-
-
-
D
LQ
L
SIRG
F
G
SRS
T
YGIRGIRLYV
DG
I
P
ATMPDG
--
QG
QT
S
N
I
D
L-
-
----
-
-
---
--
-
SS
VQNV
EVLRGP
F
SALYGN
-
A
S
GGV
M
N
VT
T
Q
T
G
Q
QPPTIEASSYYGSF
GS
W
RY
G
LK
A
TG
A
TG
D
GT
Q
P
---
G
DVDY
TV
S
TT
R
F
TTH
G
--
-
-
-
---Y
R
DH
S
GAQ
K
NL
A
N
A
-------
KLGVRIDEASK
L
S
L
IFNS
V
DIK
A
D
D
P
GG
LT
KA
E
WK
A
NPQQ
A
P
RA
E
QYD
T
R
K
-----
TIK
Q
TQ
A
G
L
R
Y
ER
SL
SSR
-----------------
D
D
M
S
V
M
M
Y
A
-------------
-
-
GERETTQ
Y
QS
I
P
M
----
APQL
N
PSHAGGVIT
L
Q
R
---
HYQ
G
I
D
-
---
-------
-
----
----
S
RWTHR
G
EL
GV
P
V
------
T
F
T
T
G
L
N
Y
ENM
S
EN
R
KGYNNFR
L
NS----
-
--
-
G
MPEYGQKGELRR
D
ER
N
L
MWN
I
DPYLQ
TQWQ
L
SE
K
L
S
L
D
AG
V
RY
SSVWFDSN
DH
------------
YVTP
GN
GDDSGDASYH
K
W
L
P
AGS
L
KYA
M
T
D
A
W
N
I
Y
L
A
AG
RG
FET
P
T
I
N
E
------
L
SYRAD
G
---
--
QS
G
M--
-
-----
-
-
N
L
G
LKP
S
T
N
D
T
I
EIG
SKTRIGD
GL
L
S
-
L
A
L
F
Q
TD
TD
DE
IV
V
-------
D
S
SSGGRTT
Y
K
N
A
GK
T
R
RQ
G
A
E
L
A
WDQ
R
-
FAG
D
FRVNA
S
W
TW
L
DATYRSN
VC
N
EQ
DC
---
N
G
N
----
R
MP
G
I
A
RN
M
G
F
A
S
I
G
Y
VPE
D
GWYAGTEA
R
YM
G
D
IM
A
D--
-
--
----
--
-----
D
EN
T
AKAPS
YTLVGL
FTG
Y
K
Y
N
Y
HNL
T
V
D
L
FGR
VDNLFDK
E
Y
VGSV
I
VNE
S
N
---
----
--
-----
-
-
G
R
---
Y
Y
E
PS
PGRNY
G
VG
M
N
fig|536056.3.peg.2305
Escherichia coli DH1 (29-694/700)
MIVSA
APQVVSE
L
DT
P
A
A
VSV
V
DG
EE
M
R
L
A
-
TPRI
N
LSE
S
L
T
G
-
VPG
L
Q
V
QNR
Q
NY
A
Q-
-
-
D
LQ
L
SIRG
F
G
SRS
T
YGIRGIRLYV
DG
I
P
ATMPDG
--
QG
QT
S
N
I
D
L-
-
----
-
-
---
--
-
SS
VQNV
EVLRGP
F
SALYGN
-
A
S
GGV
M
N
VT
T
Q
T
G
Q
QPPTIEASSYYGSF
GS
W
RY
G
LK
A
TG
A
TG
D
GT
Q
P
---
G
DVDY
TV
S
TT
R
F
TTH
G
--
-
-
-
---Y
R
DH
S
GAQ
K
NL
A
N
A
-------
KLGVRIDEASK
L
S
L
IFNS
V
DIK
A
D
D
P
GG
LT
KA
E
WK
A
NPQQ
A
P
RA
E
QYD
T
R
K
-----
TIK
Q
TQ
A
G
L
R
Y
ER
SL
SSR
-----------------
D
D
M
S
V
M
M
Y
A
-------------
-
-
GERETTQ
Y
QS
I
P
M
----
APQL
N
PSHAGGVIT
L
Q
R
---
HYQ
G
I
D
-
---
-------
-
----
----
S
RWTHR
G
EL
GV
P
V
------
T
F
T
T
G
L
N
Y
ENM
S
EN
R
KGYNNFR
L
NS----
-
--
-
G
MPEYGQKGELRR
D
ER
N
L
MWN
I
DPYLQ
TQWQ
L
SE
K
L
S
L
D
AG
V
RY
SSVWFDSN
DH
------------
YVTP
GN
GDDSGDASYH
K
W
L
P
AGS
L
KYA
M
T
D
A
W
N
I
Y
L
A
AG
RG
FET
P
T
I
N
E
------
L
SYRAD
G
---
--
QS
G
M--
-
-----
-
-
N
L
G
LKP
S
T
N
D
T
I
EIG
SKTRIGD
GL
L
S
-
L
A
L
F
Q
TD
TD
DE
IV
V
-------
D
S
SSGGRTT
Y
K
N
A
GK
T
R
RQ
G
A
E
L
A
WDQ
R
-
FAG
D
FRVNA
S
W
TW
L
DATYRSN
VC
N
EQ
DC
---
N
G
N
----
R
MP
G
I
A
RN
M
G
F
A
S
I
G
Y
VPE
D
GWYAGTEA
R
YM
G
D
IM
A
D--
-
--
----
--
-----
D
EN
T
AKAPS
YTLVGL
FTG
Y
K
Y
N
Y
HNL
T
V
D
L
FGR
VDNLFDK
E
Y
VGSV
I
VNE
S
N
---
----
--
-----
-
-
G
R
---
Y
Y
E
PS
PGRNY
G
VG
M
N
fig|316401.4.peg.1747
Escherichia coli ETEC H10407 (29-694/700)
MIVSA
APQVVSE
L
DT
P
A
A
VSV
V
DG
EE
M
R
L
A
-
TPRI
N
LSE
S
L
T
G
-
VPG
L
Q
V
QNR
Q
NY
A
Q-
-
-
D
LQ
L
SIRG
F
G
SRS
T
YGIRGIRLYV
DG
I
P
ATMPDG
--
QG
QT
S
N
I
D
L-
-
----
-
-
---
--
-
SS
VQNV
EVLRGP
F
SALYGN
-
A
S
GGV
M
N
VT
T
Q
T
G
Q
QPPTIEASSYYGSF
GS
W
RY
G
LK
A
TG
A
TG
D
GT
Q
P
---
G
DVDY
TV
S
TT
R
F
TTH
G
--
-
-
-
---Y
R
DH
S
GAQ
K
NL
A
N
A
-------
KLGVRIDEASK
L
S
L
IFNS
V
DIK
A
D
D
P
GG
LT
KA
E
WK
A
NPQQ
A
P
RA
E
QYD
T
R
K
-----
TIK
Q
TQ
A
G
L
R
Y
ER
SL
SSR
-----------------
D
D
M
S
V
M
M
Y
A
-------------
-
-
GERETTQ
Y
QS
I
P
M
----
APQL
N
PSHAGGVIT
L
Q
R
---
HYQ
G
I
D
-
---
-------
-
----
----
S
RWTHR
G
EL
GV
P
V
------
T
F
T
T
G
L
N
Y
ENM
S
EN
R
KGYNNFR
L
NS----
-
--
-
G
MPEYGQKGELRR
D
ER
N
L
MWN
I
DPYLQ
TQWQ
L
SE
K
L
S
L
D
AG
V
RY
SSVWFDSN
DH
------------
YVTP
GN
GDDSGDASYH
K
W
L
P
AGS
L
KYA
M
T
D
A
W
N
I
Y
L
A
AG
RG
FET
P
T
I
N
E
------
L
SYRAD
G
---
--
QS
G
M--
-
-----
-
-
N
L
G
LKP
S
T
N
D
T
I
EIG
SKTRIGD
GL
L
S
-
L
A
L
F
Q
TD
TD
DE
IV
V
-------
D
S
SSGGRTT
Y
K
N
A
GK
T
R
RQ
G
A
E
L
A
WDQ
R
-
FAG
D
FRVNA
S
W
TW
L
DATYRSN
VC
N
EQ
DC
---
N
G
N
----
R
MP
G
I
A
RN
M
G
F
A
S
I
G
Y
VPE
D
GWYAGTEA
R
YM
G
D
IM
A
D--
-
--
----
--
-----
D
EN
T
AKAPS
YTLVGL
FTG
Y
K
Y
N
Y
HNL
T
V
D
L
FGR
VDNLFDK
E
Y
VGSV
I
VNE
S
N
---
----
--
-----
-
-
G
R
---
Y
Y
E
PS
PGRNY
G
VG
M
N
fig|656414.3.peg.1738
Escherichia coli H736 (29-694/700)
MIVSA
APQVVSE
L
DT
P
A
A
VSV
V
DG
EE
M
R
L
A
-
TPRI
N
LSE
S
L
T
G
-
VPG
L
Q
V
QNR
Q
NY
A
Q-
-
-
D
LQ
L
SIRG
F
G
SRS
T
YGIRGIRLYV
DG
I
P
ATMPDG
--
QG
QT
S
N
I
D
L-
-
----
-
-
---
--
-
SS
VQNV
EVLRGP
F
SALYGN
-
A
S
GGV
M
N
VT
T
Q
T
G
Q
QPPTIEASSYYGSF
GS
W
RY
G
LK
A
TG
A
TG
D
GT
Q
P
---
G
DVDY
TV
S
TT
R
F
TTH
G
--
-
-
-
---Y
R
DH
S
GAQ
K
NL
A
N
A
-------
KLGVRIDEASK
L
S
L
IFNS
V
DIK
A
D
D
P
GG
LT
KA
E
WK
A
NPQQ
A
P
RA
E
QYD
T
R
K
-----
TIK
Q
TQ
A
G
L
R
Y
ER
SL
SSR
-----------------
D
D
M
S
V
M
M
Y
A
-------------
-
-
GERETTQ
Y
QS
I
P
M
----
APQL
N
PSHAGGVIT
L
Q
R
---
HYQ
G
I
D
-
---
-------
-
----
----
S
RWTHR
G
EL
GV
P
V
------
T
F
T
T
G
L
N
Y
ENM
S
EN
R
KGYNNFR
L
NS----
-
--
-
G
MPEYGQKGELRR
D
ER
N
L
MWN
I
DPYLQ
TQWQ
L
SE
K
L
S
L
D
AG
V
RY
SSVWFDSN
DH
------------
YVTP
GN
GDDSGDASYH
K
W
L
P
AGS
L
KYA
M
T
D
A
W
N
I
Y
L
A
AG
RG
FET
P
T
I
N
E
------
L
SYRAD
G
---
--
QS
G
M--
-
-----
-
-
N
L
G
LKP
S
T
N
D
T
I
EIG
SKTRIGD
GL
L
S
-
L
A
L
F
Q
TD
TD
DE
IV
V
-------
D
S
SSGGRTT
Y
K
N
A
GK
T
R
RQ
G
A
E
L
A
WDQ
R
-
FAG
D
FRVNA
S
W
TW
L
DATYRSN
VC
N
EQ
DC
---
N
G
N
----
R
MP
G
I
A
RN
M
G
F
A
S
I
G
Y
VPE
D
GWYAGTEA
R
YM
G
D
IM
A
D--
-
--
----
--
-----
D
EN
T
AKAPS
YTLVGL
FTG
Y
K
Y
N
Y
HNL
T
V
D
L
FGR
VDNLFDK
E
Y
VGSV
I
VNE
S
N
---
----
--
-----
-
-
G
R
---
Y
Y
E
PS
PGRNY
G
VG
M
N
fig|83333.1.peg.1437
Escherichia coli K12 (29-694/700)
MIVSA
APQVVSE
L
DT
P
A
A
VSV
V
DG
EE
M
R
L
A
-
TPRI
N
LSE
S
L
T
G
-
VPG
L
Q
V
QNR
Q
NY
A
Q-
-
-
D
LQ
L
SIRG
F
G
SRS
T
YGIRGIRLYV
DG
I
P
ATMPDG
--
QG
QT
S
N
I
D
L-
-
----
-
-
---
--
-
SS
VQNV
EVLRGP
F
SALYGN
-
A
S
GGV
M
N
VT
T
Q
T
G
Q
QPPTIEASSYYGSF
GS
W
RY
G
LK
A
TG
A
TG
D
GT
Q
P
---
G
DVDY
TV
S
TT
R
F
TTH
G
--
-
-
-
---Y
R
DH
S
GAQ
K
NL
A
N
A
-------
KLGVRIDEASK
L
S
L
IFNS
V
DIK
A
D
D
P
GG
LT
KA
E
WK
A
NPQQ
A
P
RA
E
QYD
T
R
K
-----
TIK
Q
TQ
A
G
L
R
Y
ER
SL
SSR
-----------------
D
D
M
S
V
M
M
Y
A
-------------
-
-
GERETTQ
Y
QS
I
P
M
----
APQL
N
PSHAGGVIT
L
Q
R
---
HYQ
G
I
D
-
---
-------
-
----
----
S
RWTHR
G
EL
GV
P
V
------
T
F
T
T
G
L
N
Y
ENM
S
EN
R
KGYNNFR
L
NS----
-
--
-
G
MPEYGQKGELRR
D
ER
N
L
MWN
I
DPYLQ
TQWQ
L
SE
K
L
S
L
D
AG
V
RY
SSVWFDSN
DH
------------
YVTP
GN
GDDSGDASYH
K
W
L
P
AGS
L
KYA
M
T
D
A
W
N
I
Y
L
A
AG
RG
FET
P
T
I
N
E
------
L
SYRAD
G
---
--
QS
G
M--
-
-----
-
-
N
L
G
LKP
S
T
N
D
T
I
EIG
SKTRIGD
GL
L
S
-
L
A
L
F
Q
TD
TD
DE
IV
V
-------
D
S
SSGGRTT
Y
K
N
A
GK
T
R
RQ
G
A
E
L
A
WDQ
R
-
FAG
D
FRVNA
S
W
TW
L
DATYRSN
VC
N
EQ
DC
---
N
G
N
----
R
MP
G
I
A
RN
M
G
F
A
S
I
G
Y
VPE
D
GWYAGTEA
R
YM
G
D
IM
A
D--
-
--
----
--
-----
D
EN
T
AKAPS
YTLVGL
FTG
Y
K
Y
N
Y
HNL
T
V
D
L
FGR
VDNLFDK
E
Y
VGSV
I
VNE
S
N
---
----
--
-----
-
-
G
R
---
Y
Y
E
PS
PGRNY
G
VG
M
N
fig|749540.3.peg.1940
Escherichia coli MS 146-1 (1-666/672)
MIVSA
APQVVSE
L
DT
P
A
A
VSV
V
DG
EE
M
R
L
A
-
TPRI
N
LSE
S
L
T
G
-
VPG
L
Q
V
QNR
Q
NY
A
Q-
-
-
D
LQ
L
SIRG
F
G
SRS
T
YGIRGIRLYV
DG
I
P
ATMPDG
--
QG
QT
S
N
I
D
L-
-
----
-
-
---
--
-
SS
VQNV
EVLRGP
F
SALYGN
-
A
S
GGV
M
N
VT
T
Q
T
G
Q
QPPTIEASSYYGSF
GS
W
RY
G
LK
A
TG
A
TG
D
GT
Q
P
---
G
DVDY
TV
S
TT
R
F
TTH
G
--
-
-
-
---Y
R
DH
S
GAQ
K
NL
A
N
A
-------
KLGVRIDEASK
L
S
L
IFNS
V
DIK
A
D
D
P
GG
LT
KA
E
WK
A
NPQQ
A
P
RA
E
QYD
T
R
K
-----
TIK
Q
TQ
A
G
L
R
Y
ER
SL
SSR
-----------------
D
D
M
S
V
M
M
Y
A
-------------
-
-
GERETTQ
Y
QS
I
P
M
----
APQL
N
PSHAGGVIT
L
Q
R
---
HYQ
G
I
D
-
---
-------
-
----
----
S
RWTHR
G
EL
GV
P
V
------
T
F
T
T
G
L
N
Y
ENM
S
EN
R
KGYNNFR
L
NS----
-
--
-
G
MPEYGQKGELRR
D
ER
N
L
MWN
I
DPYLQ
TQWQ
L
SE
K
L
S
L
D
AG
V
RY
SSVWFDSN
DH
------------
YVTP
GN
GDDSGDASYH
K
W
L
P
AGS
L
KYA
M
T
D
A
W
N
I
Y
L
A
AG
RG
FET
P
T
I
N
E
------
L
SYRAD
G
---
--
QS
G
M--
-
-----
-
-
N
L
G
LKP
S
T
N
D
T
I
EIG
SKTRIGD
GL
L
S
-
L
A
L
F
Q
TD
TD
DE
IV
V
-------
D
S
SSGGRTT
Y
K
N
A
GK
T
R
RQ
G
A
E
L
A
WDQ
R
-
FAG
D
FRVNA
S
W
TW
L
DATYRSN
VC
N
EQ
DC
---
N
G
N
----
R
MP
G
I
A
RN
M
G
F
A
S
I
G
Y
VPE
D
GWYAGTEA
R
YM
G
D
IM
A
D--
-
--
----
--
-----
D
EN
T
AKAPS
YTLVGL
FTG
Y
K
Y
N
Y
HNL
T
V
D
L
FGR
VDNLFDK
E
Y
VGSV
I
VNE
S
N
---
----
--
-----
-
-
G
R
---
Y
Y
E
PS
PGRNY
G
VG
M
N
fig|749548.3.peg.4696
Escherichia coli MS 196-1 (29-694/700)
MIVSA
APQVVSE
L
DT
P
A
A
VSV
V
DG
EE
M
R
L
A
-
TPRI
N
LSE
S
L
T
G
-
VPG
L
Q
V
QNR
Q
NY
A
Q-
-
-
D
LQ
L
SIRG
F
G
SRS
T
YGIRGIRLYV
DG
I
P
ATMPDG
--
QG
QT
S
N
I
D
L-
-
----
-
-
---
--
-
SS
VQNV
EVLRGP
F
SALYGN
-
A
S
GGV
M
N
VT
T
Q
T
G
Q
QPPTIEASSYYGSF
GS
W
RY
G
LK
A
TG
A
TG
D
GT
Q
P
---
G
DVDY
TV
S
TT
R
F
TTH
G
--
-
-
-
---Y
R
DH
S
GAQ
K
NL
A
N
A
-------
KLGVRIDEASK
L
S
L
IFNS
V
DIK
A
D
D
P
GG
LT
KA
E
WK
A
NPQQ
A
P
RA
E
QYD
T
R
K
-----
TIK
Q
TQ
A
G
L
R
Y
ER
SL
SSR
-----------------
D
D
M
S
V
M
M
Y
A
-------------
-
-
GERETTQ
Y
QS
I
P
M
----
APQL
N
PSHAGGVIT
L
Q
R
---
HYQ
G
I
D
-
---
-------
-
----
----
S
RWTHR
G
EL
GV
P
V
------
T
F
T
T
G
L
N
Y
ENM
S
EN
R
KGYNNFR
L
NS----
-
--
-
G
MPEYGQKGELRR
D
ER
N
L
MWN
I
DPYLQ
TQWQ
L
SE
K
L
S
L
D
AG
V
RY
SSVWFDSN
DH
------------
YVTP
GN
GDDSGDASYH
K
W
L
P
AGS
L
KYA
M
T
D
A
W
N
I
Y
L
A
AG
RG
FET
P
T
I
N
E
------
L
SYRAD
G
---
--
QS
G
M--
-
-----
-
-
N
L
G
LKP
S
T
N
D
T
I
EIG
SKTRIGD
GL
L
S
-
L
A
L
F
Q
TD
TD
DE
IV
V
-------
D
S
SSGGRTT
Y
K
N
A
GK
T
R
RQ
G
A
E
L
A
WDQ
R
-
FAG
D
FRVNA
S
W
TW
L
DATYRSN
VC
N
EQ
DC
---
N
G
N
----
R
MP
G
I
A
RN
M
G
F
A
S
I
G
Y
VPE
D
GWYAGTEA
R
YM
G
D
IM
A
D--
-
--
----
--
-----
D
EN
T
AKAPS
YTLVGL
FTG
Y
K
Y
N
Y
HNL
T
V
D
L
FGR
VDNLFDK
E
Y
VGSV
I
VNE
S
N
---
----
--
-----
-
-
G
R
---
Y
Y
E
PS
PGRNY
G
VG
M
N
fig|316407.3.peg.1410
Escherichia coli W3110 (29-694/700)
MIVSA
APQVVSE
L
DT
P
A
A
VSV
V
DG
EE
M
R
L
A
-
TPRI
N
LSE
S
L
T
G
-
VPG
L
Q
V
QNR
Q
NY
A
Q-
-
-
D
LQ
L
SIRG
F
G
SRS
T
YGIRGIRLYV
DG
I
P
ATMPDG
--
QG
QT
S
N
I
D
L-
-
----
-
-
---
--
-
SS
VQNV
EVLRGP
F
SALYGN
-
A
S
GGV
M
N
VT
T
Q
T
G
Q
QPPTIEASSYYGSF
GS
W
RY
G
LK
A
TG
A
TG
D
GT
Q
P
---
G
DVDY
TV
S
TT
R
F
TTH
G
--
-
-
-
---Y
R
DH
S
GAQ
K
NL
A
N
A
-------
KLGVRIDEASK
L
S
L
IFNS
V
DIK
A
D
D
P
GG
LT
KA
E
WK
A
NPQQ
A
P
RA
E
QYD
T
R
K
-----
TIK
Q
TQ
A
G
L
R
Y
ER
SL
SSR
-----------------
D
D
M
S
V
M
M
Y
A
-------------
-
-
GERETTQ
Y
QS
I
P
M
----
APQL
N
PSHAGGVIT
L
Q
R
---
HYQ
G
I
D
-
---
-------
-
----
----
S
RWTHR
G
EL
GV
P
V
------
T
F
T
T
G
L
N
Y
ENM
S
EN
R
KGYNNFR
L
NS----
-
--
-
G
MPEYGQKGELRR
D
ER
N
L
MWN
I
DPYLQ
TQWQ
L
SE
K
L
S
L
D
AG
V
RY
SSVWFDSN
DH
------------
YVTP
GN
GDDSGDASYH
K
W
L
P
AGS
L
KYA
M
T
D
A
W
N
I
Y
L
A
AG
RG
FET
P
T
I
N
E
------
L
SYRAD
G
---
--
QS
G
M--
-
-----
-
-
N
L
G
LKP
S
T
N
D
T
I
EIG
SKTRIGD
GL
L
S
-
L
A
L
F
Q
TD
TD
DE
IV
V
-------
D
S
SSGGRTT
Y
K
N
A
GK
T
R
RQ
G
A
E
L
A
WDQ
R
-
FAG
D
FRVNA
S
W
TW
L
DATYRSN
VC
N
EQ
DC
---
N
G
N
----
R
MP
G
I
A
RN
M
G
F
A
S
I
G
Y
VPE
D
GWYAGTEA
R
YM
G
D
IM
A
D--
-
--
----
--
-----
D
EN
T
AKAPS
YTLVGL
FTG
Y
K
Y
N
Y
HNL
T
V
D
L
FGR
VDNLFDK
E
Y
VGSV
I
VNE
S
N
---
----
--
-----
-
-
G
R
---
Y
Y
E
PS
PGRNY
G
VG
M
N
fig|316385.5.peg.1564
Escherichia coli str. K-12 substr. DH10B (29-694/700)
MIVSA
APQVVSE
L
DT
P
A
A
VSV
V
DG
EE
M
R
L
A
-
TPRI
N
LSE
S
L
T
G
-
VPG
L
Q
V
QNR
Q
NY
A
Q-
-
-
D
LQ
L
SIRG
F
G
SRS
T
YGIRGIRLYV
DG
I
P
ATMPDG
--
QG
QT
S
N
I
D
L-
-
----
-
-
---
--
-
SS
VQNV
EVLRGP
F
SALYGN
-
A
S
GGV
M
N
VT
T
Q
T
G
Q
QPPTIEASSYYGSF
GS
W
RY
G
LK
A
TG
A
TG
D
GT
Q
P
---
G
DVDY
TV
S
TT
R
F
TTH
G
--
-
-
-
---Y
R
DH
S
GAQ
K
NL
A
N
A
-------
KLGVRIDEASK
L
S
L
IFNS
V
DIK
A
D
D
P
GG
LT
KA
E
WK
A
NPQQ
A
P
RA
E
QYD
T
R
K
-----
TIK
Q
TQ
A
G
L
R
Y
ER
SL
SSR
-----------------
D
D
M
S
V
M
M
Y
A
-------------
-
-
GERETTQ
Y
QS
I
P
M
----
APQL
N
PSHAGGVIT
L
Q
R
---
HYQ
G
I
D
-
---
-------
-
----
----
S
RWTHR
G
EL
GV
P
V
------
T
F
T
T
G
L
N
Y
ENM
S
EN
R
KGYNNFR
L
NS----
-
--
-
G
MPEYGQKGELRR
D
ER
N
L
MWN
I
DPYLQ
TQWQ
L
SE
K
L
S
L
D
AG
V
RY
SSVWFDSN
DH
------------
YVTP
GN
GDDSGDASYH
K
W
L
P
AGS
L
KYA
M
T
D
A
W
N
I
Y
L
A
AG
RG
FET
P
T
I
N
E
------
L
SYRAD
G
---
--
QS
G
M--
-
-----
-
-
N
L
G
LKP
S
T
N
D
T
I
EIG
SKTRIGD
GL
L
S
-
L
A
L
F
Q
TD
TD
DE
IV
V
-------
D
S
SSGGRTT
Y
K
N
A
GK
T
R
RQ
G
A
E
L
A
WDQ
R
-
FAG
D
FRVNA
S
W
TW
L
DATYRSN
VC
N
EQ
DC
---
N
G
N
----
R
MP
G
I
A
RN
M
G
F
A
S
I
G
Y
VPE
D
GWYAGTEA
R
YM
G
D
IM
A
D--
-
--
----
--
-----
D
EN
T
AKAPS
YTLVGL
FTG
Y
K
Y
N
Y
HNL
T
V
D
L
FGR
VDNLFDK
E
Y
VGSV
I
VNE
S
N
---
----
--
-----
-
-
G
R
---
Y
Y
E
PS
PGRNY
G
VG
M
N
fig|316385.7.peg.1604
Escherichia coli str. K-12 substr. DH10B (29-694/700)
MIVSA
APQVVSE
L
DT
P
A
A
VSV
V
DG
EE
M
R
L
A
-
TPRI
N
LSE
S
L
T
G
-
VPG
L
Q
V
QNR
Q
NY
A
Q-
-
-
D
LQ
L
SIRG
F
G
SRS
T
YGIRGIRLYV
DG
I
P
ATMPDG
--
QG
QT
S
N
I
D
L-
-
----
-
-
---
--
-
SS
VQNV
EVLRGP
F
SALYGN
-
A
S
GGV
M
N
VT
T
Q
T
G
Q
QPPTIEASSYYGSF
GS
W
RY
G
LK
A
TG
A
TG
D
GT
Q
P
---
G
DVDY
TV
S
TT
R
F
TTH
G
--
-
-
-
---Y
R
DH
S
GAQ
K
NL
A
N
A
-------
KLGVRIDEASK
L
S
L
IFNS
V
DIK
A
D
D
P
GG
LT
KA
E
WK
A
NPQQ
A
P
RA
E
QYD
T
R
K
-----
TIK
Q
TQ
A
G
L
R
Y
ER
SL
SSR
-----------------
D
D
M
S
V
M
M
Y
A
-------------
-
-
GERETTQ
Y
QS
I
P
M
----
APQL
N
PSHAGGVIT
L
Q
R
---
HYQ
G
I
D
-
---
-------
-
----
----
S
RWTHR
G
EL
GV
P
V
------
T
F
T
T
G
L
N
Y
ENM
S
EN
R
KGYNNFR
L
NS----
-
--
-
G
MPEYGQKGELRR
D
ER
N
L
MWN
I
DPYLQ
TQWQ
L
SE
K
L
S
L
D
AG
V
RY
SSVWFDSN
DH
------------
YVTP
GN
GDDSGDASYH
K
W
L
P
AGS
L
KYA
M
T
D
A
W
N
I
Y
L
A
AG
RG
FET
P
T
I
N
E
------
L
SYRAD
G
---
--
QS
G
M--
-
-----
-
-
N
L
G
LKP
S
T
N
D
T
I
EIG
SKTRIGD
GL
L
S
-
L
A
L
F
Q
TD
TD
DE
IV
V
-------
D
S
SSGGRTT
Y
K
N
A
GK
T
R
RQ
G
A
E
L
A
WDQ
R
-
FAG
D
FRVNA
S
W
TW
L
DATYRSN
VC
N
EQ
DC
---
N
G
N
----
R
MP
G
I
A
RN
M
G
F
A
S
I
G
Y
VPE
D
GWYAGTEA
R
YM
G
D
IM
A
D--
-
--
----
--
-----
D
EN
T
AKAPS
YTLVGL
FTG
Y
K
Y
N
Y
HNL
T
V
D
L
FGR
VDNLFDK
E
Y
VGSV
I
VNE
S
N
---
----
--
-----
-
-
G
R
---
Y
Y
E
PS
PGRNY
G
VG
M
N
fig|511145.12.peg.1517
Escherichia coli str. K-12 substr. MG1655 (29-694/700)
MIVSA
APQVVSE
L
DT
P
A
A
VSV
V
DG
EE
M
R
L
A
-
TPRI
N
LSE
S
L
T
G
-
VPG
L
Q
V
QNR
Q
NY
A
Q-
-
-
D
LQ
L
SIRG
F
G
SRS
T
YGIRGIRLYV
DG
I
P
ATMPDG
--
QG
QT
S
N
I
D
L-
-
----
-
-
---
--
-
SS
VQNV
EVLRGP
F
SALYGN
-
A
S
GGV
M
N
VT
T
Q
T
G
Q
QPPTIEASSYYGSF
GS
W
RY
G
LK
A
TG
A
TG
D
GT
Q
P
---
G
DVDY
TV
S
TT
R
F
TTH
G
--
-
-
-
---Y
R
DH
S
GAQ
K
NL
A
N
A
-------
KLGVRIDEASK
L
S
L
IFNS
V
DIK
A
D
D
P
GG
LT
KA
E
WK
A
NPQQ
A
P
RA
E
QYD
T
R
K
-----
TIK
Q
TQ
A
G
L
R
Y
ER
SL
SSR
-----------------
D
D
M
S
V
M
M
Y
A
-------------
-
-
GERETTQ
Y
QS
I
P
M
----
APQL
N
PSHAGGVIT
L
Q
R
---
HYQ
G
I
D
-
---
-------
-
----
----
S
RWTHR
G
EL
GV
P
V
------
T
F
T
T
G
L
N
Y
ENM
S
EN
R
KGYNNFR
L
NS----
-
--
-
G
MPEYGQKGELRR
D
ER
N
L
MWN
I
DPYLQ
TQWQ
L
SE
K
L
S
L
D
AG
V
RY
SSVWFDSN
DH
------------
YVTP
GN
GDDSGDASYH
K
W
L
P
AGS
L
KYA
M
T
D
A
W
N
I
Y
L
A
AG
RG
FET
P
T
I
N
E
------
L
SYRAD
G
---
--
QS
G
M--
-
-----
-
-
N
L
G
LKP
S
T
N
D
T
I
EIG
SKTRIGD
GL
L
S
-
L
A
L
F
Q
TD
TD
DE
IV
V
-------
D
S
SSGGRTT
Y
K
N
A
GK
T
R
RQ
G
A
E
L
A
WDQ
R
-
FAG
D
FRVNA
S
W
TW
L
DATYRSN
VC
N
EQ
DC
---
N
G
N
----
R
MP
G
I
A
RN
M
G
F
A
S
I
G
Y
VPE
D
GWYAGTEA
R
YM
G
D
IM
A
D--
-
--
----
--
-----
D
EN
T
AKAPS
YTLVGL
FTG
Y
K
Y
N
Y
HNL
T
V
D
L
FGR
VDNLFDK
E
Y
VGSV
I
VNE
S
N
---
----
--
-----
-
-
G
R
---
Y
Y
E
PS
PGRNY
G
VG
M
N
fig|511145.6.peg.1503
Escherichia coli str. K-12 substr. MG1655 (29-694/700)
MIVSA
APQVVSE
L
DT
P
A
A
VSV
V
DG
EE
M
R
L
A
-
TPRI
N
LSE
S
L
T
G
-
VPG
L
Q
V
QNR
Q
NY
A
Q-
-
-
D
LQ
L
SIRG
F
G
SRS
T
YGIRGIRLYV
DG
I
P
ATMPDG
--
QG
QT
S
N
I
D
L-
-
----
-
-
---
--
-
SS
VQNV
EVLRGP
F
SALYGN
-
A
S
GGV
M
N
VT
T
Q
T
G
Q
QPPTIEASSYYGSF
GS
W
RY
G
LK
A
TG
A
TG
D
GT
Q
P
---
G
DVDY
TV
S
TT
R
F
TTH
G
--
-
-
-
---Y
R
DH
S
GAQ
K
NL
A
N
A
-------
KLGVRIDEASK
L
S
L
IFNS
V
DIK
A
D
D
P
GG
LT
KA
E
WK
A
NPQQ
A
P
RA
E
QYD
T
R
K
-----
TIK
Q
TQ
A
G
L
R
Y
ER
SL
SSR
-----------------
D
D
M
S
V
M
M
Y
A
-------------
-
-
GERETTQ
Y
QS
I
P
M
----
APQL
N
PSHAGGVIT
L
Q
R
---
HYQ
G
I
D
-
---
-------
-
----
----
S
RWTHR
G
EL
GV
P
V
------
T
F
T
T
G
L
N
Y
ENM
S
EN
R
KGYNNFR
L
NS----
-
--
-
G
MPEYGQKGELRR
D
ER
N
L
MWN
I
DPYLQ
TQWQ
L
SE
K
L
S
L
D
AG
V
RY
SSVWFDSN
DH
------------
YVTP
GN
GDDSGDASYH
K
W
L
P
AGS
L
KYA
M
T
D
A
W
N
I
Y
L
A
AG
RG
FET
P
T
I
N
E
------
L
SYRAD
G
---
--
QS
G
M--
-
-----
-
-
N
L
G
LKP
S
T
N
D
T
I
EIG
SKTRIGD
GL
L
S
-
L
A
L
F
Q
TD
TD
DE
IV
V
-------
D
S
SSGGRTT
Y
K
N
A
GK
T
R
RQ
G
A
E
L
A
WDQ
R
-
FAG
D
FRVNA
S
W
TW
L
DATYRSN
VC
N
EQ
DC
---
N
G
N
----
R
MP
G
I
A
RN
M
G
F
A
S
I
G
Y
VPE
D
GWYAGTEA
R
YM
G
D
IM
A
D--
-
--
----
--
-----
D
EN
T
AKAPS
YTLVGL
FTG
Y
K
Y
N
Y
HNL
T
V
D
L
FGR
VDNLFDK
E
Y
VGSV
I
VNE
S
N
---
----
--
-----
-
-
G
R
---
Y
Y
E
PS
PGRNY
G
VG
M
N
fig|656379.3.peg.3487
Escherichia coli FVEC1302 (29-694/700)
MIVSA
APQVVSE
L
DT
P
A
A
VSV
V
DG
EE
M
R
L
A
-
TPRI
N
LSE
S
L
T
S
-
VPG
L
Q
V
QNR
Q
NY
A
Q-
-
-
D
LQ
L
SIRG
F
G
SRS
T
YGIRGIRLYV
DG
I
P
ATMPDG
--
QG
QT
S
N
I
D
L-
-
----
-
-
---
--
-
SS
VQNV
EVLRGP
F
SALYGN
-
A
S
GGV
M
N
V
IT
Q
T
G
Q
QPPTIEASSYYGSF
GS
W
RY
G
LK
A
TG
A
MG
D
GT
Q
P
---
G
DVDY
TV
S
TT
R
F
TTH
G
--
-
-
-
---Y
R
DH
S
GAQ
K
NL
A
N
A
-------
KLGVRIDDASK
L
S
L
IFNS
V
DIK
A
D
D
P
GG
LT
E
A
E
WK
A
NPQQ
A
P
RA
E
QYD
T
R
K
-----
TIK
Q
TQ
A
G
L
R
Y
ER
SL
SAQ
-----------------
D
D
M
S
V
M
M
Y
A
-------------
-
-
GERETTQ
Y
QS
I
P
M
----
APQL
N
PSHAGGVIT
L
Q
R
---
HYQ
G
I
D
-
---
-------
-
----
----
S
RWTHR
G
EL
GV
P
L
------
T
F
T
T
G
L
N
Y
ENM
S
EN
R
KGYNNFR
L
NS----
-
--
-
G
VPEYGQKGELRR
D
ER
N
L
MWN
V
DPYLQ
TQWQ
L
SE
K
L
S
L
D
AG
V
RY
SSVWFDSN
DH
------------
YVTP
GN
GDDSGDASYH
K
W
L
P
AGS
L
KYA
M
T
D
A
W
N
I
Y
L
A
AG
RG
FET
P
T
I
N
E
------
L
SYRAD
G
---
--
QS
G
M--
-
-----
-
-
N
F
G
LKP
S
T
N
D
T
I
EIG
SKTRIGD
GL
L
S
-
L
A
L
F
Q
TD
TD
DE
IV
V
-------
D
S
SSGGRTT
Y
K
N
A
GK
T
R
RQ
A
A
E
L
A
WDQ
R
-
FAG
D
FRVKA
S
W
TW
L
DATYRSN
VC
N
EQ
DC
---
N
G
N
----
R
MP
G
I
A
RN
M
G
F
A
S
I
G
Y
VPE
D
GWYAGTEA
R
YM
G
D
IM
A
D--
-
--
----
--
-----
D
EN
T
AKAPS
YTLVGL
FTG
Y
K
Y
N
Y
HNL
T
V
D
L
FGR
VDNLFDK
E
Y
VGSV
I
VNE
S
N
---
----
--
-----
-
-
G
R
---
Y
Y
E
PA
PGRNY
G
VG
M
N
fig|656380.3.peg.2841
Escherichia coli FVEC1412 (29-694/700)
MIVSA
APQVVSE
L
DT
P
A
A
VSV
V
DG
EE
M
R
L
A
-
TPRI
N
LSE
S
L
T
S
-
VPG
L
Q
V
QNR
Q
NY
A
Q-
-
-
D
LQ
L
SIRG
F
G
SRS
T
YGIRGIRLYV
DG
I
P
ATMPDG
--
QG
QT
S
N
I
D
L-
-
----
-
-
---
--
-
SS
VQNV
EVLRGP
F
SALYGN
-
A
S
GGV
M
N
V
IT
Q
T
G
Q
QPPTIEASSYYGSF
GS
W
RY
G
LK
A
TG
A
MG
D
GT
Q
P
---
G
DVDY
TV
S
TT
R
F
TTH
G
--
-
-
-
---Y
R
DH
S
GAQ
K
NL
A
N
A
-------
KLGVRIDDASK
L
S
L
IFNS
V
DIK
A
D
D
P
GG
LT
E
A
E
WK
A
NPQQ
A
P
RA
E
QYD
T
R
K
-----
TIK
Q
TQ
A
G
L
R
Y
ER
SL
SAQ
-----------------
D
D
M
S
V
M
M
Y
A
-------------
-
-
GERETTQ
Y
QS
I
P
M
----
APQL
N
PSHAGGVIT
L
Q
R
---
HYQ
G
I
D
-
---
-------
-
----
----
S
RWTHR
G
EL
GV
P
L
------
T
F
T
T
G
L
N
Y
ENM
S
EN
R
KGYNNFR
L
NS----
-
--
-
G
VPEYGQKGELRR
D
ER
N
L
MWN
V
DPYLQ
TQWQ
L
SE
K
L
S
L
D
AG
V
RY
SSVWFDSN
DH
------------
YVTP
GN
GDDSGDASYH
K
W
L
P
AGS
L
KYA
M
T
D
A
W
N
I
Y
L
A
AG
RG
FET
P
T
I
N
E
------
L
SYRAD
G
---
--
QS
G
M--
-
-----
-
-
N
F
G
LKP
S
T
N
D
T
I
EIG
SKTRIGD
GL
L
S
-
L
A
L
F
Q
TD
TD
DE
IV
V
-------
D
S
SSGGRTT
Y
K
N
A
GK
T
R
RQ
A
A
E
L
A
WDQ
R
-
FAG
D
FRVKA
S
W
TW
L
DATYRSN
VC
N
EQ
DC
---
N
G
N
----
R
MP
G
I
A
RN
M
G
F
A
S
I
G
Y
VPE
D
GWYAGTEA
R
YM
G
D
IM
A
D--
-
--
----
--
-----
D
EN
T
AKAPS
YTLVGL
FTG
Y
K
Y
N
Y
HNL
T
V
D
L
FGR
VDNLFDK
E
Y
VGSV
I
VNE
S
N
---
----
--
-----
-
-
G
R
---
Y
Y
E
PA
PGRNY
G
VG
M
N
fig|585056.7.peg.1891
Escherichia coli UMN026 (82-747/753)
MIVSA
APQVVSE
L
DT
P
A
A
VSV
V
DG
EE
M
R
L
A
-
TPRI
N
LSE
S
L
T
S
-
VPG
L
Q
V
QNR
Q
NY
A
Q-
-
-
D
LQ
L
SIRG
F
G
SRS
T
YGIRGIRLYV
DG
I
P
ATMPDG
--
QG
QT
S
N
I
D
L-
-
----
-
-
---
--
-
SS
VQNV
EVLRGP
F
SALYGN
-
A
S
GGV
M
N
V
IT
Q
T
G
Q
QPPTIEASSYYGSF
GS
W
RY
G
LK
A
TG
A
MG
D
GT
Q
P
---
G
DVDY
TV
S
TT
R
F
TTH
G
--
-
-
-
---Y
R
DH
S
GAQ
K
NL
A
N
A
-------
KLGVRIDDASK
L
S
L
IFNS
V
DIK
A
D
D
P
GG
LT
E
A
E
WK
A
NPQQ
A
P
RA
E
QYD
T
R
K
-----
TIK
Q
TQ
A
G
L
R
Y
ER
SL
SAQ
-----------------
D
D
M
S
V
M
M
Y
A
-------------
-
-
GERETTQ
Y
QS
I
P
M
----
APQL
N
PSHAGGVIT
L
Q
R
---
HYQ
G
I
D
-
---
-------
-
----
----
S
RWTHR
G
EL
GV
P
L
------
T
F
T
T
G
L
N
Y
ENM
S
EN
R
KGYNNFR
L
NS----
-
--
-
G
VPEYGQKGELRR
D
ER
N
L
MWN
V
DPYLQ
TQWQ
L
SE
K
L
S
L
D
AG
V
RY
SSVWFDSN
DH
------------
YVTP
GN
GDDSGDASYH
K
W
L
P
AGS
L
KYA
M
T
D
A
W
N
I
Y
L
A
AG
RG
FET
P
T
I
N
E
------
L
SYRAD
G
---
--
QS
G
M--
-
-----
-
-
N
F
G
LKP
S
T
N
D
T
I
EIG
SKTRIGD
GL
L
S
-
L
A
L
F
Q
TD
TD
DE
IV
V
-------
D
S
SSGGRTT
Y
K
N
A
GK
T
R
RQ
A
A
E
L
A
WDQ
R
-
FAG
D
FRVKA
S
W
TW
L
DATYRSN
VC
N
EQ
DC
---
N
G
N
----
R
MP
G
I
A
RN
M
G
F
A
S
I
G
Y
VPE
D
GWYAGTEA
R
YM
G
D
IM
A
D--
-
--
----
--
-----
D
EN
T
AKAPS
YTLVGL
FTG
Y
K
Y
N
Y
HNL
T
V
D
L
FGR
VDNLFDK
E
Y
VGSV
I
VNE
S
N
---
----
--
-----
-
-
G
R
---
Y
Y
E
PA
PGRNY
G
VG
M
N
fig|344601.3.peg.222
Escherichia coli B171 (29-694/700)
MIVSA
APQVVSE
L
DT
P
A
A
VSV
V
DG
EE
M
R
L
A
-
TSRI
N
LSE
S
L
T
G
-
VPG
L
Q
V
QNR
Q
NY
A
Q-
-
-
D
LQ
L
SIRG
F
G
SRS
T
YGIRGIRLYV
DG
I
P
ATMPDG
--
QG
QT
S
N
I
D
L-
-
----
-
-
---
--
-
SS
VQNV
EVLRGP
F
SALYGN
-
A
S
GGV
M
N
VT
T
Q
T
G
Q
QPPTIEASSYYGSF
GS
W
RY
G
LK
A
TG
A
TG
D
GT
Q
P
---
G
DVDY
TV
S
TT
R
F
TTH
G
--
-
-
-
---Y
R
DH
S
GAQ
K
NL
A
N
A
-------
KLGVRIDEASK
L
S
L
IFNS
V
DIK
A
D
D
P
GG
LT
KA
E
WK
A
NPQQ
A
P
RA
E
QYD
T
R
K
-----
TIK
Q
TQ
A
G
L
R
Y
ER
SL
SAQ
-----------------
D
D
M
S
V
M
M
Y
A
-------------
-
-
GERETTQ
Y
QS
I
P
M
----
APQL
N
PSHAGGVIT
L
Q
R
---
HYQ
G
I
D
-
---
-------
-
----
----
S
RWTHR
G
EL
GV
P
V
------
T
F
T
T
G
L
N
Y
ENM
S
EN
R
KGYNNFR
L
NS----
-
--
-
G
MPEYGQKGELRR
D
ER
N
L
MWN
I
DPYLQ
TQWQ
L
SE
K
L
S
L
D
AG
V
RY
SSVWFDSN
DH
------------
YVTP
GN
GDDSGDASYH
K
W
L
P
AGS
L
KYA
M
T
D
A
W
N
I
Y
L
A
AG
RG
FET
P
T
I
N
E
------
L
SYRAD
G
---
--
QS
G
M--
-
-----
-
-
N
F
G
LKP
S
T
N
D
T
I
EIG
SKTRIGD
GL
L
S
-
L
A
L
F
Q
TD
TD
DE
IV
V
-------
D
S
SSGGRTT
Y
K
N
A
GK
T
R
RQ
G
A
E
L
A
WDQ
R
-
FAG
D
FRVNA
S
W
TW
L
DATYRSN
VC
N
EQ
DC
---
N
G
N
----
R
MP
G
I
A
RN
M
G
F
A
S
I
G
Y
VPE
D
GWYAGTEA
R
YM
G
D
IM
A
D--
-
--
----
--
-----
D
EN
T
AKAPS
YTLVGL
FTG
Y
K
Y
N
Y
HNL
T
V
D
L
FGR
VDNLFDK
E
Y
VGSV
I
VNE
S
N
---
----
--
-----
-
-
G
R
---
Y
Y
E
PS
PGRNY
G
VG
M
N
fig|344601.5.peg.219
Escherichia coli B171 (29-694/700)
MIVSA
APQVVSE
L
DT
P
A
A
VSV
V
DG
EE
M
R
L
A
-
TSRI
N
LSE
S
L
T
G
-
VPG
L
Q
V
QNR
Q
NY
A
Q-
-
-
D
LQ
L
SIRG
F
G
SRS
T
YGIRGIRLYV
DG
I
P
ATMPDG
--
QG
QT
S
N
I
D
L-
-
----
-
-
---
--
-
SS
VQNV
EVLRGP
F
SALYGN
-
A
S
GGV
M
N
VT
T
Q
T
G
Q
QPPTIEASSYYGSF
GS
W
RY
G
LK
A
TG
A
TG
D
GT
Q
P
---
G
DVDY
TV
S
TT
R
F
TTH
G
--
-
-
-
---Y
R
DH
S
GAQ
K
NL
A
N
A
-------
KLGVRIDEASK
L
S
L
IFNS
V
DIK
A
D
D
P
GG
LT
KA
E
WK
A
NPQQ
A
P
RA
E
QYD
T
R
K
-----
TIK
Q
TQ
A
G
L
R
Y
ER
SL
SAQ
-----------------
D
D
M
S
V
M
M
Y
A
-------------
-
-
GERETTQ
Y
QS
I
P
M
----
APQL
N
PSHAGGVIT
L
Q
R
---
HYQ
G
I
D
-
---
-------
-
----
----
S
RWTHR
G
EL
GV
P
V
------
T
F
T
T
G
L
N
Y
ENM
S
EN
R
KGYNNFR
L
NS----
-
--
-
G
MPEYGQKGELRR
D
ER
N
L
MWN
I
DPYLQ
TQWQ
L
SE
K
L
S
L
D
AG
V
RY
SSVWFDSN
DH
------------
YVTP
GN
GDDSGDASYH
K
W
L
P
AGS
L
KYA
M
T
D
A
W
N
I
Y
L
A
AG
RG
FET
P
T
I
N
E
------
L
SYRAD
G
---
--
QS
G
M--
-
-----
-
-
N
F
G
LKP
S
T
N
D
T
I
EIG
SKTRIGD
GL
L
S
-
L
A
L
F
Q
TD
TD
DE
IV
V
-------
D
S
SSGGRTT
Y
K
N
A
GK
T
R
RQ
G
A
E
L
A
WDQ
R
-
FAG
D
FRVNA
S
W
TW
L
DATYRSN
VC
N
EQ
DC
---
N
G
N
----
R
MP
G
I
A
RN
M
G
F
A
S
I
G
Y
VPE
D
GWYAGTEA
R
YM
G
D
IM
A
D--
-
--
----
--
-----
D
EN
T
AKAPS
YTLVGL
FTG
Y
K
Y
N
Y
HNL
T
V
D
L
FGR
VDNLFDK
E
Y
VGSV
I
VNE
S
N
---
----
--
-----
-
-
G
R
---
Y
Y
E
PS
PGRNY
G
VG
M
N
fig|340185.3.peg.1084
Escherichia coli E22 (29-694/700)
MIVSA
APQVVSE
L
DT
P
A
A
VSV
V
DG
EE
M
R
L
A
-
TSRI
N
LSE
S
L
T
G
-
VPG
L
Q
V
QNR
Q
NY
A
Q-
-
-
D
LQ
L
SIRG
F
G
SRS
T
YGIRGIRLYV
DG
I
P
ATMPDG
--
QG
QT
S
N
I
D
L-
-
----
-
-
---
--
-
SS
VQNV
EVLRGP
F
SALYGN
-
A
S
GGV
M
N
VT
T
Q
T
G
Q
QPPTIEASSYYGSF
GS
W
RY
G
LK
A
TG
A
TG
D
GT
Q
P
---
G
DVDY
TV
S
TT
R
F
TTH
G
--
-
-
-
---Y
R
DH
S
GAQ
K
NL
A
N
A
-------
KLGVRIDEASK
L
S
L
IFNS
V
DIK
A
D
D
P
GG
LT
KA
E
WK
A
NPQQ
A
P
RA
E
QYD
T
R
K
-----
TIK
Q
TQ
A
G
L
R
Y
ER
SL
SAQ
-----------------
D
D
M
S
V
M
M
Y
A
-------------
-
-
GERETTQ
Y
QS
I
P
M
----
APQL
N
PSHAGGVIT
L
Q
R
---
HYQ
G
I
D
-
---
-------
-
----
----
S
RWTHR
G
EL
GV
P
V
------
T
F
T
T
G
L
N
Y
ENM
S
EN
R
KGYNNFR
L
NS----
-
--
-
G
MPEYGQKGELRR
D
ER
N
L
MWN
I
DPYLQ
TQWQ
L
SE
K
L
S
L
D
AG
V
RY
SSVWFDSN
DH
------------
YVTP
GN
GDDSGDASYH
K
W
L
P
AGS
L
KYA
M
T
D
A
W
N
I
Y
L
A
AG
RG
FET
P
T
I
N
E
------
L
SYRAD
G
---
--
QS
G
M--
-
-----
-
-
N
F
G
LKP
S
T
N
D
T
I
EIG
SKTRIGD
GL
L
S
-
L
A
L
F
Q
TD
TD
DE
IV
V
-------
D
S
SSGGRTT
Y
K
N
A
GK
T
R
RQ
G
A
E
L
A
WDQ
R
-
FAG
D
FRVNA
S
W
TW
L
DATYRSN
VC
N
EQ
DC
---
N
G
N
----
R
MP
G
I
A
RN
M
G
F
A
S
I
G
Y
VPE
D
GWYAGTEA
R
YM
G
D
IM
A
D--
-
--
----
--
-----
D
EN
T
AKAPS
YTLVGL
FTG
Y
K
Y
N
Y
HNL
T
V
D
L
FGR
VDNLFDK
E
Y
VGSV
I
VNE
S
N
---
----
--
-----
-
-
G
R
---
Y
Y
E
PS
PGRNY
G
VG
M
N
fig|340185.4.peg.1139
Escherichia coli E22 (29-694/700)
MIVSA
APQVVSE
L
DT
P
A
A
VSV
V
DG
EE
M
R
L
A
-
TSRI
N
LSE
S
L
T
G
-
VPG
L
Q
V
QNR
Q
NY
A
Q-
-
-
D
LQ
L
SIRG
F
G
SRS
T
YGIRGIRLYV
DG
I
P
ATMPDG
--
QG
QT
S
N
I
D
L-
-
----
-
-
---
--
-
SS
VQNV
EVLRGP
F
SALYGN
-
A
S
GGV
M
N
VT
T
Q
T
G
Q
QPPTIEASSYYGSF
GS
W
RY
G
LK
A
TG
A
TG
D
GT
Q
P
---
G
DVDY
TV
S
TT
R
F
TTH
G
--
-
-
-
---Y
R
DH
S
GAQ
K
NL
A
N
A
-------
KLGVRIDEASK
L
S
L
IFNS
V
DIK
A
D
D
P
GG
LT
KA
E
WK
A
NPQQ
A
P
RA
E
QYD
T
R
K
-----
TIK
Q
TQ
A
G
L
R
Y
ER
SL
SAQ
-----------------
D
D
M
S
V
M
M
Y
A
-------------
-
-
GERETTQ
Y
QS
I
P
M
----
APQL
N
PSHAGGVIT
L
Q
R
---
HYQ
G
I
D
-
---
-------
-
----
----
S
RWTHR
G
EL
GV
P
V
------
T
F
T
T
G
L
N
Y
ENM
S
EN
R
KGYNNFR
L
NS----
-
--
-
G
MPEYGQKGELRR
D
ER
N
L
MWN
I
DPYLQ
TQWQ
L
SE
K
L
S
L
D
AG
V
RY
SSVWFDSN
DH
------------
YVTP
GN
GDDSGDASYH
K
W
L
P
AGS
L
KYA
M
T
D
A
W
N
I
Y
L
A
AG
RG
FET
P
T
I
N
E
------
L
SYRAD
G
---
--
QS
G
M--
-
-----
-
-
N
F
G
LKP
S
T
N
D
T
I
EIG
SKTRIGD
GL
L
S
-
L
A
L
F
Q
TD
TD
DE
IV
V
-------
D
S
SSGGRTT
Y
K
N
A
GK
T
R
RQ
G
A
E
L
A
WDQ
R
-
FAG
D
FRVNA
S
W
TW
L
DATYRSN
VC
N
EQ
DC
---
N
G
N
----
R
MP
G
I
A
RN
M
G
F
A
S
I
G
Y
VPE
D
GWYAGTEA
R
YM
G
D
IM
A
D--
-
--
----
--
-----
D
EN
T
AKAPS
YTLVGL
FTG
Y
K
Y
N
Y
HNL
T
V
D
L
FGR
VDNLFDK
E
Y
VGSV
I
VNE
S
N
---
----
--
-----
-
-
G
R
---
Y
Y
E
PS
PGRNY
G
VG
M
N
fig|585395.4.peg.1658
Escherichia coli O103:H2 str. 12009 (29-694/700)
MIVSA
APQVVSE
L
DT
P
A
A
VSV
V
DG
EE
M
R
L
A
-
TSRI
N
LSE
S
L
T
G
-
VPG
L
Q
V
QNR
Q
NY
A
Q-
-
-
D
LQ
L
SIRG
F
G
SRS
T
YGIRGIRLYV
DG
I
P
ATMPDG
--
QG
QT
S
N
I
D
L-
-
----
-
-
---
--
-
SS
VQNV
EVLRGP
F
SALYGN
-
A
S
GGV
M
N
VT
T
Q
T
G
Q
QPPTIEASSYYGSF
GS
W
RY
G
LK
A
TG
A
TG
D
GT
Q
P
---
G
DVDY
TV
S
TT
R
F
TTH
G
--
-
-
-
---Y
R
DH
S
GAQ
K
NL
A
N
A
-------
KLGVRIDEASK
L
S
L
IFNS
V
DIK
A
D
D
P
GG
LT
KA
E
WK
A
NPQQ
A
P
RA
E
QYD
T
R
K
-----
TIK
Q
TQ
A
G
L
R
Y
ER
SL
SAQ
-----------------
D
D
M
S
V
M
M
Y
A
-------------
-
-
GERETTQ
Y
QS
I
P
M
----
APQL
N
PSHAGGVIT
L
Q
R
---
HYQ
G
I
D
-
---
-------
-
----
----
S
RWTHR
G
EL
GV
P
V
------
T
F
T
T
G
L
N
Y
ENM
S
EN
R
KGYNNFR
L
NS----
-
--
-
G
MPEYGQKGELRR
D
ER
N
L
MWN
I
DPYLQ
TQWQ
L
SE
K
L
S
L
D
AG
V
RY
SSVWFDSN
DH
------------
YVTP
GN
GDDSGDASYH
K
W
L
P
AGS
L
KYA
M
T
D
A
W
N
I
Y
L
A
AG
RG
FET
P
T
I
N
E
------
L
SYRAD
G
---
--
QS
G
M--
-
-----
-
-
N
F
G
LKP
S
T
N
D
T
I
EIG
SKTRIGD
GL
L
S
-
L
A
L
F
Q
TD
TD
DE
IV
V
-------
D
S
SSGGRTT
Y
K
N
A
GK
T
R
RQ
G
A
E
L
A
WDQ
R
-
FAG
D
FRVNA
S
W
TW
L
DATYRSN
VC
N
EQ
DC
---
N
G
N
----
R
MP
G
I
A
RN
M
G
F
A
S
I
G
Y
VPE
D
GWYAGTEA
R
YM
G
D
IM
A
D--
-
--
----
--
-----
D
EN
T
AKAPS
YTLVGL
FTG
Y
K
Y
N
Y
HNL
T
V
D
L
FGR
VDNLFDK
E
Y
VGSV
I
VNE
S
N
---
----
--
-----
-
-
G
R
---
Y
Y
E
PS
PGRNY
G
VG
M
N
fig|749549.3.peg.3868
Escherichia coli MS 198-1 (29-694/700)
MIVSA
APQVVSE
L
DT
P
A
A
VSV
V
DG
EE
M
R
L
A
-
TPRI
N
LSE
S
L
T
S
-
VPG
L
Q
V
QNR
Q
NY
A
Q-
-
-
D
LQ
L
SIRG
F
G
SRS
T
YGIRGIRLYV
DG
I
P
ATMPDG
--
QG
QT
S
N
I
D
L-
-
----
-
-
---
--
-
SS
VQNV
EVLRGP
F
SALYGN
-
A
S
GGV
M
N
V
IT
Q
T
G
Q
R
PPTIEASSYYGSF
GS
W
RY
G
LK
A
TG
A
MG
D
GT
Q
P
---
G
DVDY
TV
S
TT
R
F
TTH
G
--
-
-
-
---Y
R
DH
S
GAQ
K
NL
A
N
A
-------
KLGVRIDDASK
L
S
L
IFNS
V
DIK
A
D
D
P
GG
LT
E
A
E
WK
A
NPQQ
A
P
RA
E
QYD
T
R
K
-----
TIK
Q
TQ
A
G
L
R
Y
ER
SL
SAQ
-----------------
D
D
M
S
V
M
M
Y
A
-------------
-
-
GERETTQ
Y
QS
I
P
M
----
APQL
N
PSHAGGVIT
L
Q
R
---
HYQ
G
I
D
-
---
-------
-
----
----
S
RWTHR
G
EL
GV
P
L
------
T
F
T
T
G
L
N
Y
ENM
S
EN
R
KGYNNFR
L
NS----
-
--
-
G
VPEYGQKGELRR
D
ER
N
L
MWN
V
DPYLQ
TQWQ
L
SE
K
L
S
L
D
AG
V
RY
SSVWFDSN
DH
------------
YVTP
GN
GDDSGDASYH
K
W
L
P
AGS
L
KYA
M
T
D
A
W
N
I
Y
L
A
AG
RG
FET
P
T
I
N
E
------
L
SYRAD
G
---
--
QS
G
M--
-
-----
-
-
N
F
G
LKP
S
T
N
D
T
I
EIG
SKTRIGD
GL
L
S
-
L
A
L
F
Q
TD
TD
DE
IV
V
-------
D
S
SSGGRTT
Y
K
N
A
GK
T
R
RQ
A
A
E
L
A
WDQ
R
-
FAG
D
FRVKA
S
W
TW
L
DATYRSN
VC
N
EQ
DC
---
N
G
N
----
R
MP
G
I
A
RN
M
G
F
A
S
I
G
Y
VPE
D
GWYAGTEA
R
YM
G
D
IM
A
D--
-
--
----
--
-----
D
EN
T
AKAPS
YTLVGL
FTG
Y
K
Y
N
Y
HNL
T
V
D
L
FGR
VDNLFDK
E
Y
VGSV
I
VNE
S
N
---
----
--
-----
-
-
G
R
---
Y
Y
E
PA
PGRNY
G
VG
M
N
fig|155864.1.peg.2018
Escherichia coli O157:H7 EDL933 (29-694/700)
MIVSA
APQVVSE
L
DT
P
A
A
VSV
V
DG
EE
M
R
L
A
-
TPRI
N
LSE
S
L
T
G
-
VPG
L
Q
V
QNR
Q
NY
A
Q-
-
-
D
LQ
L
SIRG
F
G
SRS
T
YGIRGIRLYV
DG
I
P
XTMPDG
--
QG
QT
S
N
I
D
L-
-
----
-
-
---
--
-
SS
VQNV
EVLRGP
F
SALYGN
-
A
S
GGV
M
N
VT
T
Q
T
G
Q
QPPTIEASSYYGSF
GS
W
RY
G
LK
A
TG
A
TG
D
GT
Q
P
---
G
DVDY
TV
S
TT
R
F
TTH
G
--
-
-
-
---Y
R
DH
S
GAQ
K
NL
A
N
A
-------
KLGVRIDDASK
L
S
L
IFNS
V
DIK
A
D
D
P
GG
LT
KA
E
WK
A
NPQQ
A
X
RA
E
QYD
T
R
K
-----
TIK
Q
TQ
A
G
L
R
Y
ER
SL
SSR
-----------------
D
D
M
S
V
M
M
Y
A
-------------
-
-
GERETTQ
Y
QS
I
P
M
----
APQL
N
PSHAGSVIT
L
Q
R
---
HYQ
G
I
D
-
---
-------
-
----
----
S
RWTHR
G
EL
GV
P
V
------
T
F
T
T
G
L
N
Y
ENM
S
EN
R
KGYNNFR
L
NS----
-
--
-
G
MPEYGQKGELRR
D
ER
N
L
MWN
I
DPYLQ
TQWQ
L
SE
K
L
S
L
D
AG
V
RY
SSVWFDSN
DH
------------
YVTP
GN
GDDSGDASYH
K
W
L
P
AGS
L
KYA
M
T
D
A
W
N
I
Y
L
A
AG
RG
FET
P
T
I
N
E
------
L
SYRAD
G
---
--
QS
G
M--
-
-----
-
-
N
F
G
LKP
S
T
N
D
T
I
EIG
SKTRIGD
GL
L
S
-
L
A
L
F
Q
TD
TD
DE
IV
V
-------
D
S
SSGGRTT
Y
K
N
A
GK
T
R
RQ
G
A
E
L
A
WDQ
R
-
FAG
D
FRVNA
S
W
TW
L
DATYRSN
VC
N
EQ
DC
---
N
G
N
----
R
MP
G
I
A
RN
M
G
F
A
S
I
G
Y
VPE
D
GWYAGMEA
R
YM
G
D
IM
A
D--
-
--
----
--
-----
D
EN
T
AKAPS
YTLVGL
FTG
Y
K
Y
N
Y
HNL
T
V
D
L
FGR
VDNLFDK
E
Y
VGSV
I
VNE
S
N
---
----
--
-----
-
-
G
R
---
Y
Y
E
PA
PGRNY
G
VG
VN
fig|155864.8.peg.1843
Escherichia coli O157:H7 EDL933 (29-694/700)
MIVSA
APQVVSE
L
DT
P
A
A
VSV
V
DG
EE
M
R
L
A
-
TPRI
N
LSE
S
L
T
G
-
VPG
L
Q
V
QNR
Q
NY
A
Q-
-
-
D
LQ
L
SIRG
F
G
SRS
T
YGIRGIRLYV
DG
I
P
XTMPDG
--
QG
QT
S
N
I
D
L-
-
----
-
-
---
--
-
SS
VQNV
EVLRGP
F
SALYGN
-
A
S
GGV
M
N
VT
T
Q
T
G
Q
QPPTIEASSYYGSF
GS
W
RY
G
LK
A
TG
A
TG
D
GT
Q
P
---
G
DVDY
TV
S
TT
R
F
TTH
G
--
-
-
-
---Y
R
DH
S
GAQ
K
NL
A
N
A
-------
KLGVRIDDASK
L
S
L
IFNS
V
DIK
A
D
D
P
GG
LT
KA
E
WK
A
NPQQ
A
X
RA
E
QYD
T
R
K
-----
TIK
Q
TQ
A
G
L
R
Y
ER
SL
SSR
-----------------
D
D
M
S
V
M
M
Y
A
-------------
-
-
GERETTQ
Y
QS
I
P
M
----
APQL
N
PSHAGSVIT
L
Q
R
---
HYQ
G
I
D
-
---
-------
-
----
----
S
RWTHR
G
EL
GV
P
V
------
T
F
T
T
G
L
N
Y
ENM
S
EN
R
KGYNNFR
L
NS----
-
--
-
G
MPEYGQKGELRR
D
ER
N
L
MWN
I
DPYLQ
TQWQ
L
SE
K
L
S
L
D
AG
V
RY
SSVWFDSN
DH
------------
YVTP
GN
GDDSGDASYH
K
W
L
P
AGS
L
KYA
M
T
D
A
W
N
I
Y
L
A
AG
RG
FET
P
T
I
N
E
------
L
SYRAD
G
---
--
QS
G
M--
-
-----
-
-
N
F
G
LKP
S
T
N
D
T
I
EIG
SKTRIGD
GL
L
S
-
L
A
L
F
Q
TD
TD
DE
IV
V
-------
D
S
SSGGRTT
Y
K
N
A
GK
T
R
RQ
G
A
E
L
A
WDQ
R
-
FAG
D
FRVNA
S
W
TW
L
DATYRSN
VC
N
EQ
DC
---
N
G
N
----
R
MP
G
I
A
RN
M
G
F
A
S
I
G
Y
VPE
D
GWYAGMEA
R
YM
G
D
IM
A
D--
-
--
----
--
-----
D
EN
T
AKAPS
YTLVGL
FTG
Y
K
Y
N
Y
HNL
T
V
D
L
FGR
VDNLFDK
E
Y
VGSV
I
VNE
S
N
---
----
--
-----
-
-
G
R
---
Y
Y
E
PA
PGRNY
G
VG
VN
fig|550672.3.peg.945
Escherichia coli B088 (29-694/700)
MIVSA
APQVVSE
L
DT
P
A
A
VSV
V
DG
EE
M
R
L
A
-
TPRI
N
LSE
S
L
T
G
-
VPG
L
Q
V
QNR
Q
NY
A
Q-
-
-
D
LQ
L
SIRG
F
G
SRS
T
YGIRGIRLYV
DG
I
P
ATMPDG
--
QG
QT
S
N
I
D
L-
-
----
-
-
---
--
-
SS
VQNV
EVLRGP
F
SALYGN
-
A
S
GGV
M
N
VT
T
Q
T
G
Q
QPPTIEASSYYGSF
GS
W
RY
G
LK
A
TG
A
TG
D
GT
Q
P
---
G
DVDY
TV
S
TT
R
F
TTH
G
--
-
-
-
---Y
R
DH
S
GAQ
K
NL
A
N
A
-------
KLGVRIDEASK
L
S
L
IFNS
V
DIK
A
D
D
P
GG
LT
KA
E
WK
A
NPQQ
A
P
RA
E
QYD
T
R
K
-----
TIK
Q
TQ
A
G
L
R
Y
ER
SL
SAQ
-----------------
D
D
M
S
V
M
M
Y
A
-------------
-
-
GERETTQ
Y
QS
I
P
M
----
APQL
N
PSHAGGVIT
L
Q
R
---
HYQ
G
I
D
-
---
-------
-
----
----
S
RWTHR
G
EL
GV
P
V
------
T
F
T
T
G
L
N
Y
ENM
S
EN
R
KGYNNFR
L
NS----
-
--
-
G
MPEYGQKGELRR
D
ER
N
L
MWN
I
DPYLQ
TQWQ
L
SE
K
L
S
L
D
AG
V
RY
SSVWFDSN
DH
------------
YVTP
GN
GDDSGDASYH
K
W
L
P
AGS
L
KYA
M
T
D
A
W
N
I
Y
L
A
AG
RG
FET
P
T
I
N
E
------
L
SYRAD
G
---
--
QS
G
M--
-
-----
-
-
N
F
G
LKP
S
T
N
D
T
I
EIG
SKTRIGD
GL
L
S
-
L
A
L
F
Q
TD
TD
DE
IV
V
-------
D
S
SSGGRTT
Y
K
N
A
GK
T
R
RQ
G
A
E
L
A
WDQ
R
-
FAG
D
FRVNA
S
W
TW
L
DATYRSN
VC
N
EQ
DC
---
N
G
N
----
R
MP
G
I
A
RN
M
G
F
A
S
I
G
Y
VPE
D
GWYAGTEA
R
YM
G
D
IM
A
D--
-
--
----
--
-----
D
EN
T
AKAPS
YTLVGL
FTG
Y
K
Y
N
Y
HNL
T
V
D
L
FGR
VDNLFDK
E
Y
VGSV
I
VNE
S
N
---
----
--
-----
-
-
G
R
---
Y
Y
E
PS
PGRNY
G
VG
M
N
fig|340186.3.peg.193
Escherichia coli E110019 (29-694/700)
MIVSA
APQVVSE
L
DT
P
A
A
VSV
V
DG
EE
M
R
L
A
-
TPRI
N
LSE
S
L
T
G
-
VPG
L
Q
V
QNR
Q
NY
A
Q-
-
-
D
LQ
L
SIRG
F
G
SRS
T
YGIRGIRLYV
DG
I
P
ATMPDG
--
QG
QT
S
N
I
D
L-
-
----
-
-
---
--
-
SS
VQNV
EVLRGP
F
SALYGN
-
A
S
GGV
M
N
VT
T
Q
T
G
Q
QPPTIEASSYYGSF
GS
W
RY
G
LK
A
TG
A
TG
D
GT
Q
P
---
G
DVDY
TV
S
TT
R
F
TTH
G
--
-
-
-
---Y
R
DH
S
GAQ
K
NL
A
N
A
-------
KLGVRIDEASK
L
S
L
IFNS
V
DIK
A
D
D
P
GG
LT
KA
E
WK
A
NPQQ
A
P
RA
E
QYD
T
R
K
-----
TIK
Q
TQ
A
G
L
R
Y
ER
SL
SAQ
-----------------
D
D
M
S
V
M
M
Y
A
-------------
-
-
GERETTQ
Y
QS
I
P
M
----
APQL
N
PSHAGGVIT
L
Q
R
---
HYQ
G
I
D
-
---
-------
-
----
----
S
RWTHR
G
EL
GV
P
V
------
T
F
T
T
G
L
N
Y
ENM
S
EN
R
KGYNNFR
L
NS----
-
--
-
G
MPEYGQKGELRR
D
ER
N
L
MWN
I
DPYLQ
TQWQ
L
SE
K
L
S
L
D
AG
V
RY
SSVWFDSN
DH
------------
YVTP
GN
GDDSGDASYH
K
W
L
P
AGS
L
KYA
M
T
D
A
W
N
I
Y
L
A
AG
RG
FET
P
T
I
N
E
------
L
SYRAD
G
---
--
QS
G
M--
-
-----
-
-
N
F
G
LKP
S
T
N
D
T
I
EIG
SKTRIGD
GL
L
S
-
L
A
L
F
Q
TD
TD
DE
IV
V
-------
D
S
SSGGRTT
Y
K
N
A
GK
T
R
RQ
G
A
E
L
A
WDQ
R
-
FAG
D
FRVNA
S
W
TW
L
DATYRSN
VC
N
EQ
DC
---
N
G
N
----
R
MP
G
I
A
RN
M
G
F
A
S
I
G
Y
VPE
D
GWYAGTEA
R
YM
G
D
IM
A
D--
-
--
----
--
-----
D
EN
T
AKAPS
YTLVGL
FTG
Y
K
Y
N
Y
HNL
T
V
D
L
FGR
VDNLFDK
E
Y
VGSV
I
VNE
S
N
---
----
--
-----
-
-
G
R
---
Y
Y
E
PS
PGRNY
G
VG
M
N
fig|340186.5.peg.208
Escherichia coli E110019 (29-694/700)
MIVSA
APQVVSE
L
DT
P
A
A
VSV
V
DG
EE
M
R
L
A
-
TPRI
N
LSE
S
L
T
G
-
VPG
L
Q
V
QNR
Q
NY
A
Q-
-
-
D
LQ
L
SIRG
F
G
SRS
T
YGIRGIRLYV
DG
I
P
ATMPDG
--
QG
QT
S
N
I
D
L-
-
----
-
-
---
--
-
SS
VQNV
EVLRGP
F
SALYGN
-
A
S
GGV
M
N
VT
T
Q
T
G
Q
QPPTIEASSYYGSF
GS
W
RY
G
LK
A
TG
A
TG
D
GT
Q
P
---
G
DVDY
TV
S
TT
R
F
TTH
G
--
-
-
-
---Y
R
DH
S
GAQ
K
NL
A
N
A
-------
KLGVRIDEASK
L
S
L
IFNS
V
DIK
A
D
D
P
GG
LT
KA
E
WK
A
NPQQ
A
P
RA
E
QYD
T
R
K
-----
TIK
Q
TQ
A
G
L
R
Y
ER
SL
SAQ
-----------------
D
D
M
S
V
M
M
Y
A
-------------
-
-
GERETTQ
Y
QS
I
P
M
----
APQL
N
PSHAGGVIT
L
Q
R
---
HYQ
G
I
D
-
---
-------
-
----
----
S
RWTHR
G
EL
GV
P
V
------
T
F
T
T
G
L
N
Y
ENM
S
EN
R
KGYNNFR
L
NS----
-
--
-
G
MPEYGQKGELRR
D
ER
N
L
MWN
I
DPYLQ
TQWQ
L
SE
K
L
S
L
D
AG
V
RY
SSVWFDSN
DH
------------
YVTP
GN
GDDSGDASYH
K
W
L
P
AGS
L
KYA
M
T
D
A
W
N
I
Y
L
A
AG
RG
FET
P
T
I
N
E
------
L
SYRAD
G
---
--
QS
G
M--
-
-----
-
-
N
F
G
LKP
S
T
N
D
T
I
EIG
SKTRIGD
GL
L
S
-
L
A
L
F
Q
TD
TD
DE
IV
V
-------
D
S
SSGGRTT
Y
K
N
A
GK
T
R
RQ
G
A
E
L
A
WDQ
R
-
FAG
D
FRVNA
S
W
TW
L
DATYRSN
VC
N
EQ
DC
---
N
G
N
----
R
MP
G
I
A
RN
M
G
F
A
S
I
G
Y
VPE
D
GWYAGTEA
R
YM
G
D
IM
A
D--
-
--
----
--
-----
D
EN
T
AKAPS
YTLVGL
FTG
Y
K
Y
N
Y
HNL
T
V
D
L
FGR
VDNLFDK
E
Y
VGSV
I
VNE
S
N
---
----
--
-----
-
-
G
R
---
Y
Y
E
PS
PGRNY
G
VG
M
N
fig|331111.12.peg.1915
Escherichia coli E24377A (29-694/700)
MIVSA
APQVVSE
L
DT
P
A
A
VSV
V
DG
EE
M
R
L
A
-
TPRI
N
LSE
S
L
T
G
-
VPG
L
Q
V
QNR
Q
NY
A
Q-
-
-
D
LQ
L
SIRG
F
G
SRS
T
YGIRGIRLYV
DG
I
P
ATMPDG
--
QG
QT
S
N
I
D
L-
-
----
-
-
---
--
-
SS
VQNV
EVLRGP
F
SALYGN
-
A
S
GGV
M
N
VT
T
Q
T
G
Q
QPPTIEASSYYGSF
GS
W
RY
G
LK
A
TG
A
TG
D
GT
Q
P
---
G
DVDY
TV
S
TT
R
F
TTH
G
--
-
-
-
---Y
R
DH
S
GAQ
K
NL
A
N
A
-------
KLGVRIDEASK
L
S
L
IFNS
V
DIK
A
D
D
P
GG
LT
KA
E
WK
A
NPQQ
A
P
RA
E
QYD
T
R
K
-----
TIK
Q
TQ
A
G
L
R
Y
ER
SL
SAQ
-----------------
D
D
M
S
V
M
M
Y
A
-------------
-
-
GERETTQ
Y
QS
I
P
M
----
APQL
N
PSHAGGVIT
L
Q
R
---
HYQ
G
I
D
-
---
-------
-
----
----
S
RWTHR
G
EL
GV
P
V
------
T
F
T
T
G
L
N
Y
ENM
S
EN
R
KGYNNFR
L
NS----
-
--
-
G
MPEYGQKGELRR
D
ER
N
L
MWN
I
DPYLQ
TQWQ
L
SE
K
L
S
L
D
AG
V
RY
SSVWFDSN
DH
------------
YVTP
GN
GDDSGDASYH
K
W
L
P
AGS
L
KYA
M
T
D
A
W
N
I
Y
L
A
AG
RG
FET
P
T
I
N
E
------
L
SYRAD
G
---
--
QS
G
M--
-
-----
-
-
N
F
G
LKP
S
T
N
D
T
I
EIG
SKTRIGD
GL
L
S
-
L
A
L
F
Q
TD
TD
DE
IV
V
-------
D
S
SSGGRTT
Y
K
N
A
GK
T
R
RQ
G
A
E
L
A
WDQ
R
-
FAG
D
FRVNA
S
W
TW
L
DATYRSN
VC
N
EQ
DC
---
N
G
N
----
R
MP
G
I
A
RN
M
G
F
A
S
I
G
Y
VPE
D
GWYAGTEA
R
YM
G
D
IM
A
D--
-
--
----
--
-----
D
EN
T
AKAPS
YTLVGL
FTG
Y
K
Y
N
Y
HNL
T
V
D
L
FGR
VDNLFDK
E
Y
VGSV
I
VNE
S
N
---
----
--
-----
-
-
G
R
---
Y
Y
E
PS
PGRNY
G
VG
M
N
fig|331111.3.peg.4075
Escherichia coli E24377A (29-694/700)
MIVSA
APQVVSE
L
DT
P
A
A
VSV
V
DG
EE
M
R
L
A
-
TPRI
N
LSE
S
L
T
G
-
VPG
L
Q
V
QNR
Q
NY
A
Q-
-
-
D
LQ
L
SIRG
F
G
SRS
T
YGIRGIRLYV
DG
I
P
ATMPDG
--
QG
QT
S
N
I
D
L-
-
----
-
-
---
--
-
SS
VQNV
EVLRGP
F
SALYGN
-
A
S
GGV
M
N
VT
T
Q
T
G
Q
QPPTIEASSYYGSF
GS
W
RY
G
LK
A
TG
A
TG
D
GT
Q
P
---
G
DVDY
TV
S
TT
R
F
TTH
G
--
-
-
-
---Y
R
DH
S
GAQ
K
NL
A
N
A
-------
KLGVRIDEASK
L
S
L
IFNS
V
DIK
A
D
D
P
GG
LT
KA
E
WK
A
NPQQ
A
P
RA
E
QYD
T
R
K
-----
TIK
Q
TQ
A
G
L
R
Y
ER
SL
SAQ
-----------------
D
D
M
S
V
M
M
Y
A
-------------
-
-
GERETTQ
Y
QS
I
P
M
----
APQL
N
PSHAGGVIT
L
Q
R
---
HYQ
G
I
D
-
---
-------
-
----
----
S
RWTHR
G
EL
GV
P
V
------
T
F
T
T
G
L
N
Y
ENM
S
EN
R
KGYNNFR
L
NS----
-
--
-
G
MPEYGQKGELRR
D
ER
N
L
MWN
I
DPYLQ
TQWQ
L
SE
K
L
S
L
D
AG
V
RY
SSVWFDSN
DH
------------
YVTP
GN
GDDSGDASYH
K
W
L
P
AGS
L
KYA
M
T
D
A
W
N
I
Y
L
A
AG
RG
FET
P
T
I
N
E
------
L
SYRAD
G
---
--
QS
G
M--
-
-----
-
-
N
F
G
LKP
S
T
N
D
T
I
EIG
SKTRIGD
GL
L
S
-
L
A
L
F
Q
TD
TD
DE
IV
V
-------
D
S
SSGGRTT
Y
K
N
A
GK
T
R
RQ
G
A
E
L
A
WDQ
R
-
FAG
D
FRVNA
S
W
TW
L
DATYRSN
VC
N
EQ
DC
---
N
G
N
----
R
MP
G
I
A
RN
M
G
F
A
S
I
G
Y
VPE
D
GWYAGTEA
R
YM
G
D
IM
A
D--
-
--
----
--
-----
D
EN
T
AKAPS
YTLVGL
FTG
Y
K
Y
N
Y
HNL
T
V
D
L
FGR
VDNLFDK
E
Y
VGSV
I
VNE
S
N
---
----
--
-----
-
-
G
R
---
Y
Y
E
PS
PGRNY
G
VG
M
N
fig|656408.3.peg.1584
Escherichia coli H591 (29-694/700)
MIVSA
APQVVSE
L
DT
P
A
A
VSV
V
DG
EE
M
R
L
A
-
TPRI
N
LSE
S
L
T
G
-
VPG
L
Q
V
QNR
Q
NY
A
Q-
-
-
D
LQ
L
SIRG
F
G
SRS
T
YGIRGIRLYV
DG
I
P
ATMPDG
--
QG
QT
S
N
I
D
L-
-
----
-
-
---
--
-
SS
VQNV
EVLRGP
F
SALYGN
-
A
S
GGV
M
N
VT
T
Q
T
G
Q
QPPTIEASSYYGSF
GS
W
RY
G
LK
A
TG
A
TG
D
GT
Q
P
---
G
DVDY
TV
S
TT
R
F
TTH
G
--
-
-
-
---Y
R
DH
S
GAQ
K
NL
A
N
A
-------
KLGVRIDEASK
L
S
L
IFNS
V
DIK
A
D
D
P
GG
LT
KA
E
WK
A
NPQQ
A
P
RA
E
QYD
T
R
K
-----
TIK
Q
TQ
A
G
L
R
Y
ER
SL
SAQ
-----------------
D
D
M
S
V
M
M
Y
A
-------------
-
-
GERETTQ
Y
QS
I
P
M
----
APQL
N
PSHAGGVIT
L
Q
R
---
HYQ
G
I
D
-
---
-------
-
----
----
S
RWTHR
G
EL
GV
P
V
------
T
F
T
T
G
L
N
Y
ENM
S
EN
R
KGYNNFR
L
NS----
-
--
-
G
MPEYGQKGELRR
D
ER
N
L
MWN
I
DPYLQ
TQWQ
L
SE
K
L
S
L
D
AG
V
RY
SSVWFDSN
DH
------------
YVTP
GN
GDDSGDASYH
K
W
L
P
AGS
L
KYA
M
T
D
A
W
N
I
Y
L
A
AG
RG
FET
P
T
I
N
E
------
L
SYRAD
G
---
--
QS
G
M--
-
-----
-
-
N
F
G
LKP
S
T
N
D
T
I
EIG
SKTRIGD
GL
L
S
-
L
A
L
F
Q
TD
TD
DE
IV
V
-------
D
S
SSGGRTT
Y
K
N
A
GK
T
R
RQ
G
A
E
L
A
WDQ
R
-
FAG
D
FRVNA
S
W
TW
L
DATYRSN
VC
N
EQ
DC
---
N
G
N
----
R
MP
G
I
A
RN
M
G
F
A
S
I
G
Y
VPE
D
GWYAGTEA
R
YM
G
D
IM
A
D--
-
--
----
--
-----
D
EN
T
AKAPS
YTLVGL
FTG
Y
K
Y
N
Y
HNL
T
V
D
L
FGR
VDNLFDK
E
Y
VGSV
I
VNE
S
N
---
----
--
-----
-
-
G
R
---
Y
Y
E
PS
PGRNY
G
VG
M
N
fig|585034.4.peg.1436
Escherichia coli IAI1 (29-694/700)
MIVSA
APQVVSE
L
DT
P
A
A
VSV
V
DG
EE
M
R
L
A
-
TPRI
N
LSE
S
L
T
G
-
VPG
L
Q
V
QNR
Q
NY
A
Q-
-
-
D
LQ
L
SIRG
F
G
SRS
T
YGIRGIRLYV
DG
I
P
ATMPDG
--
QG
QT
S
N
I
D
L-
-
----
-
-
---
--
-
SS
VQNV
EVLRGP
F
SALYGN
-
A
S
GGV
M
N
VT
T
Q
T
G
Q
QPPTIEASSYYGSF
GS
W
RY
G
LK
A
TG
A
TG
D
GT
Q
P
---
G
DVDY
TV
S
TT
R
F
TTH
G
--
-
-
-
---Y
R
DH
S
GAQ
K
NL
A
N
A
-------
KLGVRIDEASK
L
S
L
IFNS
V
DIK
A
D
D
P
GG
LT
KA
E
WK
A
NPQQ
A
P
RA
E
QYD
T
R
K
-----
TIK
Q
TQ
A
G
L
R
Y
ER
SL
SAQ
-----------------
D
D
M
S
V
M
M
Y
A
-------------
-
-
GERETTQ
Y
QS
I
P
M
----
APQL
N
PSHAGGVIT
L
Q
R
---
HYQ
G
I
D
-
---
-------
-
----
----
S
RWTHR
G
EL
GV
P
V
------
T
F
T
T
G
L
N
Y
ENM
S
EN
R
KGYNNFR
L
NS----
-
--
-
G
MPEYGQKGELRR
D
ER
N
L
MWN
I
DPYLQ
TQWQ
L
SE
K
L
S
L
D
AG
V
RY
SSVWFDSN
DH
------------
YVTP
GN
GDDSGDASYH
K
W
L
P
AGS
L
KYA
M
T
D
A
W
N
I
Y
L
A
AG
RG
FET
P
T
I
N
E
------
L
SYRAD
G
---
--
QS
G
M--
-
-----
-
-
N
F
G
LKP
S
T
N
D
T
I
EIG
SKTRIGD
GL
L
S
-
L
A
L
F
Q
TD
TD
DE
IV
V
-------
D
S
SSGGRTT
Y
K
N
A
GK
T
R
RQ
G
A
E
L
A
WDQ
R
-
FAG
D
FRVNA
S
W
TW
L
DATYRSN
VC
N
EQ
DC
---
N
G
N
----
R
MP
G
I
A
RN
M
G
F
A
S
I
G
Y
VPE
D
GWYAGTEA
R
YM
G
D
IM
A
D--
-
--
----
--
-----
D
EN
T
AKAPS
YTLVGL
FTG
Y
K
Y
N
Y
HNL
T
V
D
L
FGR
VDNLFDK
E
Y
VGSV
I
VNE
S
N
---
----
--
-----
-
-
G
R
---
Y
Y
E
PS
PGRNY
G
VG
M
N
fig|585034.5.peg.1432
Escherichia coli IAI1 (29-694/700)
MIVSA
APQVVSE
L
DT
P
A
A
VSV
V
DG
EE
M
R
L
A
-
TPRI
N
LSE
S
L
T
G
-
VPG
L
Q
V
QNR
Q
NY
A
Q-
-
-
D
LQ
L
SIRG
F
G
SRS
T
YGIRGIRLYV
DG
I
P
ATMPDG
--
QG
QT
S
N
I
D
L-
-
----
-
-
---
--
-
SS
VQNV
EVLRGP
F
SALYGN
-
A
S
GGV
M
N
VT
T
Q
T
G
Q
QPPTIEASSYYGSF
GS
W
RY
G
LK
A
TG
A
TG
D
GT
Q
P
---
G
DVDY
TV
S
TT
R
F
TTH
G
--
-
-
-
---Y
R
DH
S
GAQ
K
NL
A
N
A
-------
KLGVRIDEASK
L
S
L
IFNS
V
DIK
A
D
D
P
GG
LT
KA
E
WK
A
NPQQ
A
P
RA
E
QYD
T
R
K
-----
TIK
Q
TQ
A
G
L
R
Y
ER
SL
SAQ
-----------------
D
D
M
S
V
M
M
Y
A
-------------
-
-
GERETTQ
Y
QS
I
P
M
----
APQL
N
PSHAGGVIT
L
Q
R
---
HYQ
G
I
D
-
---
-------
-
----
----
S
RWTHR
G
EL
GV
P
V
------
T
F
T
T
G
L
N
Y
ENM
S
EN
R
KGYNNFR
L
NS----
-
--
-
G
MPEYGQKGELRR
D
ER
N
L
MWN
I
DPYLQ
TQWQ
L
SE
K
L
S
L
D
AG
V
RY
SSVWFDSN
DH
------------
YVTP
GN
GDDSGDASYH
K
W
L
P
AGS
L
KYA
M
T
D
A
W
N
I
Y
L
A
AG
RG
FET
P
T
I
N
E
------
L
SYRAD
G
---
--
QS
G
M--
-
-----
-
-
N
F
G
LKP
S
T
N
D
T
I
EIG
SKTRIGD
GL
L
S
-
L
A
L
F
Q
TD
TD
DE
IV
V
-------
D
S
SSGGRTT
Y
K
N
A
GK
T
R
RQ
G
A
E
L
A
WDQ
R
-
FAG
D
FRVNA
S
W
TW
L
DATYRSN
VC
N
EQ
DC
---
N
G
N
----
R
MP
G
I
A
RN
M
G
F
A
S
I
G
Y
VPE
D
GWYAGTEA
R
YM
G
D
IM
A
D--
-
--
----
--
-----
D
EN
T
AKAPS
YTLVGL
FTG
Y
K
Y
N
Y
HNL
T
V
D
L
FGR
VDNLFDK
E
Y
VGSV
I
VNE
S
N
---
----
--
-----
-
-
G
R
---
Y
Y
E
PS
PGRNY
G
VG
M
N
fig|679207.4.peg.1351
Escherichia coli MS 107-1 (29-694/700)
MIVSA
APQVVSE
L
DT
P
A
A
VSV
V
DG
EE
M
R
L
A
-
TPRI
N
LSE
S
L
T
G
-
VPG
L
Q
V
QNR
Q
NY
A
Q-
-
-
D
LQ
L
SIRG
F
G
SRS
T
YGIRGIRLYV
DG
I
P
ATMPDG
--
QG
QT
S
N
I
D
L-
-
----
-
-
---
--
-
SS
VQNV
EVLRGP
F
SALYGN
-
A
S
GGV
M
N
VT
T
Q
T
G
Q
QPPTIEASSYYGSF
GS
W
RY
G
LK
A
TG
A
TG
D
GT
Q
P
---
G
DVDY
TV
S
TT
R
F
TTH
G
--
-
-
-
---Y
R
DH
S
GAQ
K
NL
A
N
A
-------
KLGVRIDEASK
L
S
L
IFNS
V
DIK
A
D
D
P
GG
LT
KA
E
WK
A
NPQQ
A
P
RA
E
QYD
T
R
K
-----
TIK
Q
TQ
A
G
L
R
Y
ER
SL
SAQ
-----------------
D
D
M
S
V
M
M
Y
A
-------------
-
-
GERETTQ
Y
QS
I
P
M
----
APQL
N
PSHAGGVIT
L
Q
R
---
HYQ
G
I
D
-
---
-------
-
----
----
S
RWTHR
G
EL
GV
P
V
------
T
F
T
T
G
L
N
Y
ENM
S
EN
R
KGYNNFR
L
NS----
-
--
-
G
MPEYGQKGELRR
D
ER
N
L
MWN
I
DPYLQ
TQWQ
L
SE
K
L
S
L
D
AG
V
RY
SSVWFDSN
DH
------------
YVTP
GN
GD
E
SGDASYH
K
W
L
P
AGS
L
KYA
M
T
D
A
W
N
I
Y
L
A
AG
RG
FET
P
T
I
N
E
------
L
SYRAD
G
---
--
QS
G
M--
-
-----
-
-
N
F
G
LKP
S
T
N
D
T
I
EIG
SKTRIGD
GL
L
S
-
L
A
L
F
Q
TD
TD
DE
IV
V
-------
D
S
SSGGRTT
Y
K
N
A
GK
T
R
RQ
G
A
E
L
A
WDQ
R
-
FAG
D
FRVNA
S
W
TW
L
DATYRSN
VC
N
EQ
DC
---
N
G
N
----
R
MP
G
I
A
RN
M
G
F
A
S
I
G
Y
VPE
D
GWYAGTEA
R
YM
G
D
IM
A
D--
-
--
----
--
-----
D
EN
T
AKAPS
YTLVGL
FTG
Y
K
Y
N
Y
HNL
T
V
D
L
FGR
VDNLFDK
E
Y
VGSV
I
VNE
S
N
---
----
--
-----
-
-
G
R
---
Y
Y
E
PS
PGRNY
G
VG
M
N
fig|679206.4.peg.3003
Escherichia coli MS 119-7 (29-694/700)
MIVSA
APQVVSE
L
DT
P
A
A
VSV
V
DG
EE
M
R
L
A
-
TPRI
N
LSE
S
L
T
G
-
VPG
L
Q
V
QNR
Q
NY
A
Q-
-
-
D
LQ
L
SIRG
F
G
SRS
T
YGIRGIRLYV
DG
I
P
ATMPDG
--
QG
QT
S
N
I
D
L-
-
----
-
-
---
--
-
SS
VQNV
EVLRGP
F
SALYGN
-
A
S
GGV
M
N
VT
T
Q
T
G
Q
QPPTIEASSYYGSF
GS
W
RY
G
LK
A
TG
A
TG
D
GT
Q
P
---
G
DVDY
TV
S
TT
R
F
TTH
G
--
-
-
-
---Y
R
DH
S
GAQ
K
NL
A
N
A
-------
KLGVRIDEASK
L
S
L
IFNS
V
DIK
A
D
D
P
GG
LT
KA
E
WK
A
NPQQ
A
P
RA
E
QYD
T
R
K
-----
TIK
Q
TQ
A
G
L
R
Y
ER
SL
SAQ
-----------------
D
D
M
S
V
M
M
Y
A
-------------
-
-
GERETTQ
Y
QS
I
P
M
----
APQL
N
PSHAGGVIT
L
Q
R
---
HYQ
G
I
D
-
---
-------
-
----
----
S
RWTHR
G
EL
GV
P
V
------
T
F
T
T
G
L
N
Y
ENM
S
EN
R
KGYNNFR
L
NS----
-
--
-
G
MPEYGQKGELRR
D
ER
N
L
MWN
I
DPYLQ
TQWQ
L
SE
K
L
S
L
D
AG
V
RY
SSVWFDSN
DH
------------
YVTP
GN
GDDSGDASYH
K
W
L
P
AGS
L
KYA
M
T
D
A
W
N
I
Y
L
A
AG
RG
FET
P
T
I
N
E
------
L
SYRAD
G
---
--
QS
G
M--
-
-----
-
-
N
F
G
LKP
S
T
N
D
T
I
EIG
SKTRIGD
GL
L
S
-
L
A
L
F
Q
TD
TD
DE
IV
V
-------
D
S
SSGGRTT
Y
K
N
A
GK
T
R
RQ
G
A
E
L
A
WDQ
R
-
FAG
D
FRVNA
S
W
TW
L
DATYRSN
VC
N
EQ
DC
---
N
G
N
----
R
MP
G
I
A
RN
M
G
F
A
S
I
G
Y
VPE
D
GWYAGTEA
R
YM
G
D
IM
A
D--
-
--
----
--
-----
D
EN
T
AKAPS
YTLVGL
FTG
Y
K
Y
N
Y
HNL
T
V
D
L
FGR
VDNLFDK
E
Y
VGSV
I
VNE
S
N
---
----
--
-----
-
-
G
R
---
Y
Y
E
PS
PGRNY
G
VG
M
N
fig|679204.3.peg.1298
Escherichia coli MS 145-7 (29-694/700)
MIVSA
APQVVSE
L
DT
P
A
A
VSV
V
DG
EE
M
R
L
A
-
TPRI
N
LSE
S
L
T
G
-
VPG
L
Q
V
QNR
Q
NY
A
Q-
-
-
D
LQ
L
SIRG
F
G
SRS
T
YGIRGIRLYV
DG
I
P
ATMPDG
--
QG
QT
S
N
I
D
L-
-
----
-
-
---
--
-
SS
VQNV
EVLRGP
F
SALYGN
-
A
S
GGV
M
N
VT
T
Q
T
G
Q
QPPTIEASSYYGSF
GS
W
RY
G
LK
A
TG
A
TG
D
GT
Q
P
---
G
DVDY
TV
S
TT
R
F
TTH
G
--
-
-
-
---Y
R
DH
S
GAQ
K
NL
A
N
A
-------
KLGVRIDEASK
L
S
L
IFNS
V
DIK
A
D
D
P
GG
LT
KA
E
WK
A
NPQQ
A
P
RA
E
QYD
T
R
K
-----
TIK
Q
TQ
A
G
L
R
Y
ER
SL
SAQ
-----------------
D
D
M
S
V
M
M
Y
A
-------------
-
-
GERETTQ
Y
QS
I
P
M
----
APQL
N
PSHAGGVIT
L
Q
R
---
HYQ
G
I
D
-
---
-------
-
----
----
S
RWTHR
G
EL
GV
P
V
------
T
F
T
T
G
L
N
Y
ENM
S
EN
R
KGYNNFR
L
NS----
-
--
-
G
MPEYGQKGELRR
D
ER
N
L
MWN
I
DPYLQ
TQWQ
L
SE
K
L
S
L
D
AG
V
RY
SSVWFDSN
DH
------------
YVTP
GN
GDDSGDASYH
K
W
L
P
AGS
L
KYA
M
T
D
A
W
N
I
Y
L
A
AG
RG
FET
P
T
I
N
E
------
L
SYRAD
G
---
--
QS
G
M--
-
-----
-
-
N
F
G
LKP
S
T
N
D
T
I
EIG
SKTRIGD
GL
L
S
-
L
A
L
F
Q
TD
TD
DE
IV
V
-------
D
S
SSGGRTT
Y
K
N
A
GK
T
R
RQ
G
A
E
L
A
WDQ
R
-
FAG
D
FRVNA
S
W
TW
L
DATYRSN
VC
N
EQ
DC
---
N
G
N
----
R
MP
G
I
A
RN
M
G
F
A
S
I
G
Y
VPE
D
GWYAGTEA
R
YM
G
D
IM
A
D--
-
--
----
--
-----
D
EN
T
AKAPS
YTLVGL
FTG
Y
K
Y
N
Y
HNL
T
V
D
L
FGR
VDNLFDK
E
Y
VGSV
I
VNE
S
N
---
----
--
-----
-
-
G
R
---
Y
Y
E
PS
PGRNY
G
VG
M
N
fig|749545.3.peg.62
Escherichia coli MS 182-1 (1-666/672)
MIVSA
APQVVSE
L
DT
P
A
A
VSV
V
DG
EE
M
R
L
A
-
TPRI
N
LSE
S
L
T
G
-
VPG
L
Q
V
QNR
Q
NY
A
Q-
-
-
D
LQ
L
SIRG
F
G
SRS
T
YGIRGIRLYV
DG
I
P
ATMPDG
--
QG
QT
S
N
I
D
L-
-
----
-
-
---
--
-
SS
VQNV
EVLRGP
F
SALYGN
-
A
S
GGV
M
N
VT
T
Q
T
G
Q
QPPTIEASSYYGSF
GS
W
RY
G
LK
A
TG
A
TG
D
GT
Q
P
---
G
DVDY
TV
S
TT
R
F
TTH
G
--
-
-
-
---Y
R
DH
S
GAQ
K
NL
A
N
A
-------
KLGVRIDEASK
L
S
L
IFNS
V
DIK
A
D
D
P
GG
LT
KA
E
WK
A
NPQQ
A
P
RA
E
QYD
T
R
K
-----
TIK
Q
TQ
A
G
L
R
Y
ER
SL
SAQ
-----------------
D
D
M
S
V
M
M
Y
A
-------------
-
-
GERETTQ
Y
QS
I
P
M
----
APQL
N
PSHAGGVIT
L
Q
R
---
HYQ
G
I
D
-
---
-------
-
----
----
S
RWTHR
G
EL
GV
P
V
------
T
F
T
T
G
L
N
Y
ENM
S
EN
R
KGYNNFR
L
NS----
-
--
-
G
MPEYGQKGELRR
D
ER
N
L
MWN
I
DPYLQ
TQWQ
L
SE
K
L
S
L
D
AG
V
RY
SSVWFDSN
DH
------------
YVTP
GN
GDDSGDASYH
K
W
L
P
AGS
L
KYA
M
T
D
A
W
N
I
Y
L
A
AG
RG
FET
P
T
I
N
E
------
L
SYRAD
G
---
--
QS
G
M--
-
-----
-
-
N
F
G
LKP
S
T
N
D
T
I
EIG
SKTRIGD
GL
L
S
-
L
A
L
F
Q
TD
TD
DE
IV
V
-------
D
S
SSGGRTT
Y
K
N
A
GK
T
R
RQ
G
A
E
L
A
WDQ
R
-
FAG
D
FRVNA
S
W
TW
L
DATYRSN
VC
N
EQ
DC
---
N
G
N
----
R
MP
G
I
A
RN
M
G
F
A
S
I
G
Y
VPE
D
GWYAGTEA
R
YM
G
D
IM
A
D--
-
--
----
--
-----
D
EN
T
AKAPS
YTLVGL
FTG
Y
K
Y
N
Y
HNL
T
V
D
L
FGR
VDNLFDK
E
Y
VGSV
I
VNE
S
N
---
----
--
-----
-
-
G
R
---
Y
Y
E
PS
PGRNY
G
VG
M
N
fig|656443.3.peg.1782
Escherichia coli TA271 (29-694/700)
MIVSA
APQVVSE
L
DT
P
A
A
VSV
V
DG
EE
M
R
L
A
-
TPRI
N
LSE
S
L
T
G
-
VPG
L
Q
V
QNR
Q
NY
A
Q-
-
-
D
LQ
L
SIRG
F
G
SRS
T
YGIRGIRLYV
DG
I
P
ATMPDG
--
QG
QT
S
N
I
D
L-
-
----
-
-
---
--
-
SS
VQNV
EVLRGP
F
SALYGN
-
A
S
GGV
M
N
VT
T
Q
T
G
Q
QPPTIEASSYYGSF
GS
W
RY
G
LK
A
TG
A
TG
D
GT
Q
P
---
G
DVDY
TV
S
TT
R
F
TTH
G
--
-
-
-
---Y
R
DH
S
GAQ
K
NL
A
N
A
-------
KLGVRIDEASK
L
S
L
IFNS
V
DIK
A
D
D
P
GG
LT
KA
E
WK
A
NPQQ
A
P
RA
E
QYD
T
R
K
-----
TIK
Q
TQ
A
G
L
R
Y
ER
SL
SAQ
-----------------
D
D
M
S
V
M
M
Y
A
-------------
-
-
GERETTQ
Y
QS
I
P
M
----
APQL
N
PSHAGGVIT
L
Q
R
---
HYQ
G
I
D
-
---
-------
-
----
----
S
RWTHR
G
EL
GV
P
V
------
T
F
T
T
G
L
N
Y
ENM
S
EN
R
KGYNNFR
L
NS----
-
--
-
G
MPEYGQKGELRR
D
ER
N
L
MWN
I
DPYLQ
TQWQ
L
SE
K
L
S
L
D
AG
V
RY
SSVWFDSN
DH
------------
YVTP
GN
GDDSGDASYH
K
W
L
P
AGS
L
KYA
M
T
D
A
W
N
I
Y
L
A
AG
RG
FET
P
T
I
N
E
------
L
SYRAD
G
---
--
QS
G
M--
-
-----
-
-
N
F
G
LKP
S
T
N
D
T
I
EIG
SKTRIGD
GL
L
S
-
L
A
L
F
Q
TD
TD
DE
IV
V
-------
D
S
SSGGRTT
Y
K
N
A
GK
T
R
RQ
G
A
E
L
A
WDQ
R
-
FAG
D
FRVNA
S
W
TW
L
DATYRSN
VC
N
EQ
DC
---
N
G
N
----
R
MP
G
I
A
RN
M
G
F
A
S
I
G
Y
VPE
D
GWYAGTEA
R
YM
G
D
IM
A
D--
-
--
----
--
-----
D
EN
T
AKAPS
YTLVGL
FTG
Y
K
Y
N
Y
HNL
T
V
D
L
FGR
VDNLFDK
E
Y
VGSV
I
VNE
S
N
---
----
--
-----
-
-
G
R
---
Y
Y
E
PS
PGRNY
G
VG
M
N
fig|749547.3.peg.1265
Escherichia coli MS 187-1 (1-666/672)
MIVSA
APQVVSE
L
DT
P
A
A
VSV
V
DG
EE
M
R
L
A
-
TPRI
N
LSE
S
L
T
S
-
VPG
L
Q
V
QNR
Q
NY
A
Q-
-
-
D
LQ
L
SIRG
F
G
SRS
T
YGIRGIRLYV
DG
I
P
ATMPDG
--
QG
QT
S
N
I
D
L-
-
----
-
-
---
--
-
SS
VQNV
EVLRGP
F
SALYGN
-
A
S
GGV
M
N
VT
T
Q
T
G
Q
QPPTIEASSYYGSF
GS
W
RY
G
LK
A
TG
A
TG
D
GT
Q
P
---
G
DVDY
TV
S
TT
R
F
TTH
G
--
-
-
-
---Y
R
DH
S
GAQ
K
NL
A
N
A
-------
KLGVRIDEASK
L
S
L
IFNS
V
DIK
A
D
D
P
GG
LT
KA
E
WK
A
NPQQ
A
P
RA
E
QYD
T
R
K
-----
TIK
Q
TQ
A
G
L
R
Y
ER
SL
SSR
-----------------
D
D
M
S
V
M
M
Y
A
-------------
-
-
GERETTQ
Y
QS
I
P
M
----
T
PQL
N
PSHAGGVIT
L
Q
R
---
HYQ
G
I
D
-
---
-------
-
----
----
S
RWTHR
G
EL
GV
P
V
------
T
F
T
T
G
L
N
Y
ENM
S
EN
R
KGYNNFR
L
NS----
-
--
-
G
MPEYGQKGELRR
D
ER
N
L
MWN
I
DPYLQ
TQWQ
L
SE
K
L
S
L
D
A
D
V
RY
SSVWFDSN
DH
------------
YVTP
GN
GDDSGDASYH
K
W
L
P
AGS
L
KYA
M
T
D
A
W
N
I
Y
L
A
AG
RG
FET
P
T
I
N
E
------
L
SYRAD
G
---
--
QS
G
M--
-
-----
-
-
N
L
G
LKP
S
T
N
D
T
I
EIG
SKTRIGD
GL
L
S
-
L
A
L
F
Q
TD
TD
DE
IV
V
-------
D
S
SSGGRTT
Y
K
N
A
GK
T
R
RQ
G
A
E
L
A
WDQ
R
-
FAG
D
FRVNA
S
W
TW
L
DATYRSN
VC
N
EQ
DC
---
N
G
N
----
R
MP
G
I
A
RN
M
G
F
A
S
I
G
Y
VPE
D
GWYAGTEA
R
YM
G
D
IM
A
D--
-
--
----
--
-----
D
EN
T
AKAPS
YTLVGL
FTG
Y
K
Y
N
Y
HNL
T
V
D
L
FGR
VDNLFDK
E
Y
VGSV
I
VNE
S
N
---
----
--
-----
-
-
G
R
---
Y
Y
E
PS
PGRNY
G
VG
M
N
fig|749532.3.peg.988
Escherichia coli MS 78-1 (29-694/700)
MIVSA
APQVVSE
L
DT
P
A
A
VSV
V
DG
EE
M
R
L
A
-
TPRI
N
LSE
S
L
T
G
-
VPG
L
Q
V
QNR
Q
NY
A
Q-
-
-
D
LQ
L
SIRG
F
G
SRS
T
YGIRGIRLYV
DG
I
P
ATMPDG
--
QG
QT
S
N
I
D
L-
-
----
-
-
---
--
-
SS
VQNV
EVLRGP
F
SALYGN
-
A
S
GGV
M
N
VT
T
Q
T
G
Q
QPPTIEASSYYGSF
GS
W
RY
G
LK
A
TG
A
TG
D
GT
Q
P
---
G
DVDY
TV
S
TT
R
F
TTH
G
--
-
-
-
---Y
R
DH
S
GAQ
K
NL
A
N
A
-------
KLGVRIDEASK
L
S
L
IFNS
V
DIK
A
D
D
P
GG
LT
KA
E
WK
A
NPQQ
A
P
RA
E
QYD
T
R
K
-----
TIK
Q
TQ
A
G
L
R
Y
ER
SL
SAQ
-----------------
D
D
M
S
V
M
M
Y
A
-------------
-
-
GERETTQ
Y
QS
I
P
M
----
APQL
N
PSHAGGVIT
L
Q
R
---
HYQ
G
I
D
-
---
-------
-
----
----
S
RWTHR
G
EL
GV
P
V
------
T
F
T
T
G
L
N
Y
ENM
S
EN
R
KGYNNFR
L
NS----
-
--
-
G
MPEYGQKGELRR
D
ER
N
L
MWN
I
DPYLQ
TQWQ
L
SE
K
L
S
L
D
AG
V
RY
SSVWFDSN
DH
------------
YVTP
GN
GDDSGDASYH
K
W
L
P
VGS
L
KYA
M
T
D
A
W
N
I
Y
L
A
AG
RG
FET
P
T
I
N
E
------
L
SYRAD
G
---
--
QS
G
M--
-
-----
-
-
N
F
G
LKP
S
T
N
D
T
I
EIG
SKTRIGD
GL
L
S
-
L
A
L
F
Q
TD
TD
DE
IV
V
-------
D
S
SSGGRTT
Y
K
N
A
GK
T
R
RQ
G
A
E
L
A
WDQ
R
-
FAG
D
FRVNA
S
W
TW
L
DATYRSN
VC
N
EQ
DC
---
N
G
N
----
R
MP
G
I
A
RN
M
G
F
A
S
I
G
Y
VPE
D
GWYAGTEA
R
YM
G
D
IM
A
D--
-
--
----
--
-----
D
EN
T
AKAPS
YTLVGL
FTG
Y
K
Y
N
Y
HNL
T
V
D
L
FGR
VDNLFDK
E
Y
VGSV
I
VNE
S
N
---
----
--
-----
-
-
G
R
---
Y
Y
E
PS
PGRNY
G
VG
M
N
fig|525281.3.peg.19
Escherichia coli 83972 (29-694/700)
MIVSA
APQVVSE
L
DT
P
A
A
VSV
V
NG
EE
M
R
L
A
-
TPRI
N
LSE
S
L
T
G
-
VP
S
L
Q
V
QNR
Q
NY
A
Q-
-
-
D
LQ
L
SIRG
F
G
SRS
T
YGIRGIRLYV
DG
I
P
ATMPDG
--
QG
QT
S
N
I
D
L-
-
----
-
-
---
--
-
SS
VQNV
EVLRGP
F
SALYGN
-
A
S
GGV
M
N
VT
T
Q
T
G
Q
QPPTIEASSYYGSF
GS
W
RY
G
LK
A
TG
A
TG
D
GT
Q
P
---
G
DVDY
TV
S
TT
R
F
TTH
G
--
-
-
-
---Y
R
DH
S
GAQ
K
NL
A
N
A
-------
KLGVRIDDASK
L
S
L
IFNS
V
DIK
A
D
D
P
GG
LT
KA
E
WK
A
NPQQ
A
P
RA
E
QYD
T
R
K
-----
TIK
Q
TQ
A
G
L
R
Y
ER
SL
SAQ
-----------------
D
D
M
S
V
M
M
Y
A
-------------
-
-
GERETTQ
Y
QS
I
P
M
----
APQL
N
PSHAGGVIT
L
Q
R
---
HYQ
G
I
D
-
---
-------
-
----
----
S
RWTHR
G
EL
GV
P
L
------
T
F
T
T
G
L
N
Y
ENM
S
EN
R
KGYNNFR
L
NS----
-
--
-
G
VPEYGQKGELRR
D
ER
N
L
MWN
V
DPYLQ
TQWQ
L
SE
K
L
S
L
D
AG
V
RY
SSVWFDSN
DH
------------
YVTP
GN
GDDSGDASYH
K
W
L
P
AGS
L
KYA
M
T
D
A
W
N
I
Y
L
A
AG
RG
FET
P
T
I
N
E
------
L
SYRAD
G
---
--
QS
G
M--
-
-----
-
-
N
F
G
LKP
S
T
N
D
T
I
EIG
SKTRIGD
GL
L
S
-
L
A
L
F
Q
TD
TD
DE
IV
V
-------
D
S
SSGGRTT
Y
K
N
A
GK
T
R
RQ
G
A
E
L
A
WDQ
R
-
FAG
D
FRVKA
S
W
TW
L
DATYRSN
VC
N
EQ
DC
---
N
G
N
----
R
MP
G
I
A
RN
M
G
F
A
S
I
G
Y
IPE
D
GWYAGTEA
R
YM
G
D
IM
A
D--
-
--
----
--
-----
D
EN
T
AKAPS
YTLVGL
FTG
Y
K
Y
N
Y
HN
F
T
V
D
L
FGR
VDNLFDK
E
Y
VGSV
I
VNE
S
N
---
----
--
-----
-
-
G
R
---
Y
Y
E
PA
PGRNY
G
VG
I
N
fig|655817.3.peg.1763
Escherichia coli ABU 83972 (29-694/700)
MIVSA
APQVVSE
L
DT
P
A
A
VSV
V
NG
EE
M
R
L
A
-
TPRI
N
LSE
S
L
T
G
-
VP
S
L
Q
V
QNR
Q
NY
A
Q-
-
-
D
LQ
L
SIRG
F
G
SRS
T
YGIRGIRLYV
DG
I
P
ATMPDG
--
QG
QT
S
N
I
D
L-
-
----
-
-
---
--
-
SS
VQNV
EVLRGP
F
SALYGN
-
A
S
GGV
M
N
VT
T
Q
T
G
Q
QPPTIEASSYYGSF
GS
W
RY
G
LK
A
TG
A
TG
D
GT
Q
P
---
G
DVDY
TV
S
TT
R
F
TTH
G
--
-
-
-
---Y
R
DH
S
GAQ
K
NL
A
N
A
-------
KLGVRIDDASK
L
S
L
IFNS
V
DIK
A
D
D
P
GG
LT
KA
E
WK
A
NPQQ
A
P
RA
E
QYD
T
R
K
-----
TIK
Q
TQ
A
G
L
R
Y
ER
SL
SAQ
-----------------
D
D
M
S
V
M
M
Y
A
-------------
-
-
GERETTQ
Y
QS
I
P
M
----
APQL
N
PSHAGGVIT
L
Q
R
---
HYQ
G
I
D
-
---
-------
-
----
----
S
RWTHR
G
EL
GV
P
L
------
T
F
T
T
G
L
N
Y
ENM
S
EN
R
KGYNNFR
L
NS----
-
--
-
G
VPEYGQKGELRR
D
ER
N
L
MWN
V
DPYLQ
TQWQ
L
SE
K
L
S
L
D
AG
V
RY
SSVWFDSN
DH
------------
YVTP
GN
GDDSGDASYH
K
W
L
P
AGS
L
KYA
M
T
D
A
W
N
I
Y
L
A
AG
RG
FET
P
T
I
N
E
------
L
SYRAD
G
---
--
QS
G
M--
-
-----
-
-
N
F
G
LKP
S
T
N
D
T
I
EIG
SKTRIGD
GL
L
S
-
L
A
L
F
Q
TD
TD
DE
IV
V
-------
D
S
SSGGRTT
Y
K
N
A
GK
T
R
RQ
G
A
E
L
A
WDQ
R
-
FAG
D
FRVKA
S
W
TW
L
DATYRSN
VC
N
EQ
DC
---
N
G
N
----
R
MP
G
I
A
RN
M
G
F
A
S
I
G
Y
IPE
D
GWYAGTEA
R
YM
G
D
IM
A
D--
-
--
----
--
-----
D
EN
T
AKAPS
YTLVGL
FTG
Y
K
Y
N
Y
HN
F
T
V
D
L
FGR
VDNLFDK
E
Y
VGSV
I
VNE
S
N
---
----
--
-----
-
-
G
R
---
Y
Y
E
PA
PGRNY
G
VG
I
N
fig|358709.5.peg.941
Escherichia coli 101-1 (1-666/672)
MIVSA
APQVVSE
L
DT
P
A
A
VSV
V
DG
EE
M
R
L
A
-
TPRI
N
LSE
S
L
T
S
-
VPG
L
Q
V
QNR
Q
NY
A
Q-
-
-
D
LQ
L
SIRG
F
G
SRS
T
YGIRGIRLYV
DG
I
P
ATMPDG
--
QG
QT
S
N
I
D
L-
-
----
-
-
---
--
-
SS
VQNV
EVLRGP
F
SALYGN
-
A
S
GGV
M
N
VT
T
Q
T
G
Q
QPPTIEASSYYGSF
GS
W
RY
G
LK
A
TG
A
TG
D
GT
Q
P
---
G
DVDY
TV
S
TT
R
F
TTH
G
--
-
-
-
---Y
R
DH
S
GAQ
K
NL
A
N
A
-------
KLGVRIDEASK
L
S
L
IFNS
V
DIK
A
D
D
P
GG
LT
KA
E
WK
A
NPQQ
A
P
RA
E
QYD
T
R
K
-----
TIK
Q
TQ
A
G
L
R
Y
ER
SL
SSR
-----------------
D
D
M
S
V
M
M
Y
A
-------------
-
-
GERETTQ
Y
QS
I
P
M
----
APQL
N
PSHAGGVIT
L
Q
R
---
HYQ
G
I
D
-
---
-------
-
----
----
S
RWTHR
G
EL
GV
P
V
------
T
F
T
T
G
L
N
Y
ENM
S
EN
R
KGYNNFR
L
NS----
-
--
-
G
MPEYGQKGELRR
D
ER
N
L
MWN
I
DPYLQ
TQWQ
L
SE
K
L
S
L
D
A
D
V
RY
SSVWFDSN
DH
------------
YVTP
GN
GDDSGDASYH
K
W
L
P
AGS
L
KYA
M
T
D
A
W
N
I
Y
L
A
AG
RG
FET
P
T
I
N
E
------
L
SYRAD
G
---
--
QS
G
M--
-
-----
-
-
N
L
G
LKP
S
T
N
D
T
I
EIG
SKTRIGD
GL
L
S
-
L
A
L
F
Q
TD
TD
DE
IV
V
-------
D
S
SSGGRTT
Y
K
N
A
GK
T
R
RQ
G
A
E
L
A
WDQ
R
-
FAG
D
FRVNA
S
W
TW
L
DATYRSN
VC
N
EQ
DC
---
N
G
N
----
R
MP
G
I
A
RN
M
G
F
A
S
I
G
Y
VPE
D
GWYAGTEA
R
YM
G
D
IM
A
D--
-
--
----
--
-----
D
EN
T
AKAPS
YTLVGL
FTG
Y
K
Y
N
Y
HNL
T
V
D
L
FGR
VDNLFDK
E
Y
VGSV
I
VNE
S
N
---
----
--
-----
-
-
G
R
---
Y
Y
E
PS
PGRNY
G
VG
M
N
fig|413997.3.peg.1482
Escherichia coli B str. REL606 (1-666/672)
MIVSA
APQVVSE
L
DT
P
A
A
VSV
V
DG
EE
M
R
L
A
-
TPRI
N
LSE
S
L
T
S
-
VPG
L
Q
V
QNR
Q
NY
A
Q-
-
-
D
LQ
L
SIRG
F
G
SRS
T
YGIRGIRLYV
DG
I
P
ATMPDG
--
QG
QT
S
N
I
D
L-
-
----
-
-
---
--
-
SS
VQNV
EVLRGP
F
SALYGN
-
A
S
GGV
M
N
VT
T
Q
T
G
Q
QPPTIEASSYYGSF
GS
W
RY
G
LK
A
TG
A
TG
D
GT
Q
P
---
G
DVDY
TV
S
TT
R
F
TTH
G
--
-
-
-
---Y
R
DH
S
GAQ
K
NL
A
N
A
-------
KLGVRIDEASK
L
S
L
IFNS
V
DIK
A
D
D
P
GG
LT
KA
E
WK
A
NPQQ
A
P
RA
E
QYD
T
R
K
-----
TIK
Q
TQ
A
G
L
R
Y
ER
SL
SSR
-----------------
D
D
M
S
V
M
M
Y
A
-------------
-
-
GERETTQ
Y
QS
I
P
M
----
APQL
N
PSHAGGVIT
L
Q
R
---
HYQ
G
I
D
-
---
-------
-
----
----
S
RWTHR
G
EL
GV
P
V
------
T
F
T
T
G
L
N
Y
ENM
S
EN
R
KGYNNFR
L
NS----
-
--
-
G
MPEYGQKGELRR
D
ER
N
L
MWN
I
DPYLQ
TQWQ
L
SE
K
L
S
L
D
A
D
V
RY
SSVWFDSN
DH
------------
YVTP
GN
GDDSGDASYH
K
W
L
P
AGS
L
KYA
M
T
D
A
W
N
I
Y
L
A
AG
RG
FET
P
T
I
N
E
------
L
SYRAD
G
---
--
QS
G
M--
-
-----
-
-
N
L
G
LKP
S
T
N
D
T
I
EIG
SKTRIGD
GL
L
S
-
L
A
L
F
Q
TD
TD
DE
IV
V
-------
D
S
SSGGRTT
Y
K
N
A
GK
T
R
RQ
G
A
E
L
A
WDQ
R
-
FAG
D
FRVNA
S
W
TW
L
DATYRSN
VC
N
EQ
DC
---
N
G
N
----
R
MP
G
I
A
RN
M
G
F
A
S
I
G
Y
VPE
D
GWYAGTEA
R
YM
G
D
IM
A
D--
-
--
----
--
-----
D
EN
T
AKAPS
YTLVGL
FTG
Y
K
Y
N
Y
HNL
T
V
D
L
FGR
VDNLFDK
E
Y
VGSV
I
VNE
S
N
---
----
--
-----
-
-
G
R
---
Y
Y
E
PS
PGRNY
G
VG
M
N
fig|511693.5.peg.1520
Escherichia coli BL21 (1-666/672)
MIVSA
APQVVSE
L
DT
P
A
A
VSV
V
DG
EE
M
R
L
A
-
TPRI
N
LSE
S
L
T
S
-
VPG
L
Q
V
QNR
Q
NY
A
Q-
-
-
D
LQ
L
SIRG
F
G
SRS
T
YGIRGIRLYV
DG
I
P
ATMPDG
--
QG
QT
S
N
I
D
L-
-
----
-
-
---
--
-
SS
VQNV
EVLRGP
F
SALYGN
-
A
S
GGV
M
N
VT
T
Q
T
G
Q
QPPTIEASSYYGSF
GS
W
RY
G
LK
A
TG
A
TG
D
GT
Q
P
---
G
DVDY
TV
S
TT
R
F
TTH
G
--
-
-
-
---Y
R
DH
S
GAQ
K
NL
A
N
A
-------
KLGVRIDEASK
L
S
L
IFNS
V
DIK
A
D
D
P
GG
LT
KA
E
WK
A
NPQQ
A
P
RA
E
QYD
T
R
K
-----
TIK
Q
TQ
A
G
L
R
Y
ER
SL
SSR
-----------------
D
D
M
S
V
M
M
Y
A
-------------
-
-
GERETTQ
Y
QS
I
P
M
----
APQL
N
PSHAGGVIT
L
Q
R
---
HYQ
G
I
D
-
---
-------
-
----
----
S
RWTHR
G
EL
GV
P
V
------
T
F
T
T
G
L
N
Y
ENM
S
EN
R
KGYNNFR
L
NS----
-
--
-
G
MPEYGQKGELRR
D
ER
N
L
MWN
I
DPYLQ
TQWQ
L
SE
K
L
S
L
D
A
D
V
RY
SSVWFDSN
DH
------------
YVTP
GN
GDDSGDASYH
K
W
L
P
AGS
L
KYA
M
T
D
A
W
N
I
Y
L
A
AG
RG
FET
P
T
I
N
E
------
L
SYRAD
G
---
--
QS
G
M--
-
-----
-
-
N
L
G
LKP
S
T
N
D
T
I
EIG
SKTRIGD
GL
L
S
-
L
A
L
F
Q
TD
TD
DE
IV
V
-------
D
S
SSGGRTT
Y
K
N
A
GK
T
R
RQ
G
A
E
L
A
WDQ
R
-
FAG
D
FRVNA
S
W
TW
L
DATYRSN
VC
N
EQ
DC
---
N
G
N
----
R
MP
G
I
A
RN
M
G
F
A
S
I
G
Y
VPE
D
GWYAGTEA
R
YM
G
D
IM
A
D--
-
--
----
--
-----
D
EN
T
AKAPS
YTLVGL
FTG
Y
K
Y
N
Y
HNL
T
V
D
L
FGR
VDNLFDK
E
Y
VGSV
I
VNE
S
N
---
----
--
-----
-
-
G
R
---
Y
Y
E
PS
PGRNY
G
VG
M
N
fig|469008.4.peg.2253
Escherichia coli BL21(DE3) (1-666/672)
MIVSA
APQVVSE
L
DT
P
A
A
VSV
V
DG
EE
M
R
L
A
-
TPRI
N
LSE
S
L
T
S
-
VPG
L
Q
V
QNR
Q
NY
A
Q-
-
-
D
LQ
L
SIRG
F
G
SRS
T
YGIRGIRLYV
DG
I
P
ATMPDG
--
QG
QT
S
N
I
D
L-
-
----
-
-
---
--
-
SS
VQNV
EVLRGP
F
SALYGN
-
A
S
GGV
M
N
VT
T
Q
T
G
Q
QPPTIEASSYYGSF
GS
W
RY
G
LK
A
TG
A
TG
D
GT
Q
P
---
G
DVDY
TV
S
TT
R
F
TTH
G
--
-
-
-
---Y
R
DH
S
GAQ
K
NL
A
N
A
-------
KLGVRIDEASK
L
S
L
IFNS
V
DIK
A
D
D
P
GG
LT
KA
E
WK
A
NPQQ
A
P
RA
E
QYD
T
R
K
-----
TIK
Q
TQ
A
G
L
R
Y
ER
SL
SSR
-----------------
D
D
M
S
V
M
M
Y
A
-------------
-
-
GERETTQ
Y
QS
I
P
M
----
APQL
N
PSHAGGVIT
L
Q
R
---
HYQ
G
I
D
-
---
-------
-
----
----
S
RWTHR
G
EL
GV
P
V
------
T
F
T
T
G
L
N
Y
ENM
S
EN
R
KGYNNFR
L
NS----
-
--
-
G
MPEYGQKGELRR
D
ER
N
L
MWN
I
DPYLQ
TQWQ
L
SE
K
L
S
L
D
A
D
V
RY
SSVWFDSN
DH
------------
YVTP
GN
GDDSGDASYH
K
W
L
P
AGS
L
KYA
M
T
D
A
W
N
I
Y
L
A
AG
RG
FET
P
T
I
N
E
------
L
SYRAD
G
---
--
QS
G
M--
-
-----
-
-
N
L
G
LKP
S
T
N
D
T
I
EIG
SKTRIGD
GL
L
S
-
L
A
L
F
Q
TD
TD
DE
IV
V
-------
D
S
SSGGRTT
Y
K
N
A
GK
T
R
RQ
G
A
E
L
A
WDQ
R
-
FAG
D
FRVNA
S
W
TW
L
DATYRSN
VC
N
EQ
DC
---
N
G
N
----
R
MP
G
I
A
RN
M
G
F
A
S
I
G
Y
VPE
D
GWYAGTEA
R
YM
G
D
IM
A
D--
-
--
----
--
-----
D
EN
T
AKAPS
YTLVGL
FTG
Y
K
Y
N
Y
HNL
T
V
D
L
FGR
VDNLFDK
E
Y
VGSV
I
VNE
S
N
---
----
--
-----
-
-
G
R
---
Y
Y
E
PS
PGRNY
G
VG
M
N
fig|656419.3.peg.2024
Escherichia coli M718 (1-666/672)
MIVSA
APQVVSE
L
DT
P
A
A
VSV
V
DG
EE
M
R
L
A
-
TPRI
N
LSE
S
L
T
G
-
VPG
L
Q
V
QNR
Q
NY
A
Q-
-
-
D
LQ
L
SIRG
F
G
SRS
T
YGIRGIRLYV
DG
I
P
ATMPDG
--
QG
QT
S
N
I
D
L-
-
----
-
-
---
--
-
SS
VQNV
EVLRGP
F
SALYGN
-
A
S
GGV
M
N
VT
T
Q
T
G
Q
QPPTIEA
N
SYYGSF
GS
W
RY
G
LK
A
TG
A
TG
D
GT
Q
P
---
G
DVDY
TV
S
TT
R
F
TTH
G
--
-
-
-
---Y
R
DH
S
GAQ
K
NL
A
N
A
-------
KLGVRIDEASK
L
S
L
IFNS
V
DIK
A
D
D
P
GG
LT
KA
E
WK
A
NPQQ
A
P
RA
E
QYD
T
R
K
-----
TIK
Q
TQ
A
G
L
R
Y
ER
SL
SSR
-----------------
D
D
M
S
V
M
M
Y
A
-------------
-
-
GERETTQ
Y
QS
I
P
M
----
APQL
N
PSHAGGVIT
L
Q
R
---
HYQ
G
I
D
-
---
-------
-
----
----
S
RWTHR
G
EL
GV
P
V
------
T
F
T
T
G
L
N
Y
ENM
S
EN
R
KGYNNFR
L
NS----
-
--
-
G
MPEYGQKGELRR
D
ER
N
L
MWN
I
DPYLQ
TQWQ
L
SE
K
L
S
L
D
AG
V
RY
SSVWFDSN
DH
------------
YVTP
GN
GDDSGDASYH
K
W
L
P
AGS
L
KYA
M
T
D
A
W
N
I
Y
L
A
AG
RG
FET
P
T
I
N
E
------
L
SYRAD
G
---
--
QS
G
M--
-
-----
-
-
N
F
G
LKP
S
T
N
D
T
I
EIG
SKTRIGD
GL
L
S
-
L
A
L
F
Q
TD
TD
DE
IV
V
-------
D
S
SSGGRTT
Y
K
N
A
GK
T
R
RQ
G
A
E
L
A
WDQ
R
-
FAG
D
FRVNA
S
W
TW
L
DATYRSN
VC
N
EQ
DC
---
N
G
N
----
R
MP
G
I
A
RN
M
G
F
A
S
I
G
Y
VPE
D
GWYAGTEA
R
YM
G
D
IM
A
D--
-
--
----
--
-----
D
EN
T
AKAPS
YTLVGL
FTG
Y
K
Y
N
Y
HNL
T
V
D
L
FGR
VDNLFDK
E
Y
VGSV
I
VNE
S
N
---
----
--
-----
-
-
G
R
---
Y
Y
E
PA
PGRNY
G
VG
M
N
fig|637912.3.peg.3520
Escherichia coli OP50 (1-666/672)
MIVSA
APQVVSE
L
DT
P
A
A
VSV
V
DG
EE
M
R
L
A
-
TPRI
N
LSE
S
L
T
S
-
VPG
L
Q
V
QNR
Q
NY
A
Q-
-
-
D
LQ
L
SIRG
F
G
SRS
T
YGIRGIRLYV
DG
I
P
ATMPDG
--
QG
QT
S
N
I
D
L-
-
----
-
-
---
--
-
SS
VQNV
EVLRGP
F
SALYGN
-
A
S
GGV
M
N
VT
T
Q
T
G
Q
QPPTIEASSYYGSF
GS
W
RY
G
LK
A
TG
A
TG
D
GT
Q
P
---
G
DVDY
TV
S
TT
R
F
TTH
G
--
-
-
-
---Y
R
DH
S
GAQ
K
NL
A
N
A
-------
KLGVRIDEASK
L
S
L
IFNS
V
DIK
A
D
D
P
GG
LT
KA
E
WK
A
NPQQ
A
P
RA
E
QYD
T
R
K
-----
TIK
Q
TQ
A
G
L
R
Y
ER
SL
SSR
-----------------
D
D
M
S
V
M
M
Y
A
-------------
-
-
GERETTQ
Y
QS
I
P
M
----
APQL
N
PSHAGGVIT
L
Q
R
---
HYQ
G
I
D
-
---
-------
-
----
----
S
RWTHR
G
EL
GV
P
V
------
T
F
T
T
G
L
N
Y
ENM
S
EN
R
KGYNNFR
L
NS----
-
--
-
G
MPEYGQKGELRR
D
ER
N
L
MWN
I
DPYLQ
TQWQ
L
SE
K
L
S
L
D
A
D
V
RY
SSVWFDSN
DH
------------
YVTP
GN
GDDSGDASYH
K
W
L
P
AGS
L
KYA
M
T
D
A
W
N
I
Y
L
A
AG
RG
FET
P
T
I
N
E
------
L
SYRAD
G
---
--
QS
G
M--
-
-----
-
-
N
L
G
LKP
S
T
N
D
T
I
EIG
SKTRIGD
GL
L
S
-
L
A
L
F
Q
TD
TD
DE
IV
V
-------
D
S
SSGGRTT
Y
K
N
A
GK
T
R
RQ
G
A
E
L
A
WDQ
R
-
FAG
D
FRVNA
S
W
TW
L
DATYRSN
VC
N
EQ
DC
---
N
G
N
----
R
MP
G
I
A
RN
M
G
F
A
S
I
G
Y
VPE
D
GWYAGTEA
R
YM
G
D
IM
A
D--
-
--
----
--
-----
D
EN
T
AKAPS
YTLVGL
FTG
Y
K
Y
N
Y
HNL
T
V
D
L
FGR
VDNLFDK
E
Y
VGSV
I
VNE
S
N
---
----
--
-----
-
-
G
R
---
Y
Y
E
PS
PGRNY
G
VG
M
N
fig|562.371.peg.1762
Escherichia coli 1044A (29-694/700)
MIVSA
APQVVSE
L
DT
P
A
A
VSV
V
DG
EE
M
R
L
A
-
TPRI
N
LSE
S
L
T
G
-
VPG
L
Q
V
QNR
Q
NY
A
Q-
-
-
D
LQ
L
SIRG
F
G
SRS
T
YGIRGIRLYV
DG
I
P
ATMPDG
--
QG
QT
S
N
I
D
L-
-
----
-
-
---
--
-
SS
VQNV
EVLRGP
F
SALYGN
-
A
S
GGV
M
N
VT
T
Q
T
G
Q
QPPTIEASSYYGSF
GS
W
RY
G
LK
A
TG
A
TG
D
GT
Q
P
---
G
DVDY
TV
S
TT
R
F
TTH
G
--
-
-
-
---Y
R
DH
S
GAQ
K
NL
A
N
A
-------
KLGVRIDDASK
L
S
L
IFNS
V
DIK
A
D
D
P
GG
LT
KA
E
WK
A
NPQQ
A
P
RA
E
QYD
T
R
K
-----
TIK
Q
TQ
A
G
L
R
Y
ER
SL
SSR
-----------------
D
D
M
S
V
M
M
Y
A
-------------
-
-
GERETTQ
Y
QS
I
P
M
----
APQL
N
PSHAGSVIT
L
Q
R
---
HYQ
G
I
D
-
---
-------
-
----
----
S
RWTHR
G
EL
GV
P
V
------
T
F
T
T
G
L
N
Y
ENM
S
EN
R
KGYNNFR
L
NS----
-
--
-
G
MPEYGQKGELRR
D
ER
N
L
MWN
I
DPYLQ
TQWQ
L
SE
K
L
S
L
D
AG
V
RY
SSVWFDSN
DH
------------
YVTP
GN
GDDSGDASYH
K
W
L
P
AGS
L
KYA
M
T
D
A
W
N
I
Y
L
A
AG
RG
FET
P
T
I
N
E
------
L
SYRAD
G
---
--
QS
G
M--
-
-----
-
-
N
F
G
LKP
S
T
N
D
T
I
EIG
SKTRIGD
GL
L
S
-
L
A
L
F
Q
TD
TD
DE
IV
V
-------
D
S
SSGGRTT
Y
K
N
A
GK
T
R
RQ
G
A
E
L
A
WDQ
R
-
FAG
D
FRVNA
S
W
TW
L
DATYRSN
VC
N
EQ
DC
---
N
G
N
----
R
MP
G
I
A
RN
M
G
F
A
S
I
G
Y
VPE
D
GWYAGMEA
R
YM
G
D
IM
A
D--
-
--
----
--
-----
D
EN
T
AKAPS
YTLVGL
FTG
Y
K
Y
N
Y
HNL
T
V
D
L
FGR
VDNLFDK
E
Y
VGSV
I
VNE
S
N
---
----
--
-----
-
-
G
R
---
Y
Y
E
PA
PGRNY
G
VG
VN
fig|562.373.peg.5108
Escherichia coli 1125A (29-694/700)
MIVSA
APQVVSE
L
DT
P
A
A
VSV
V
DG
EE
M
R
L
A
-
TPRI
N
LSE
S
L
T
G
-
VPG
L
Q
V
QNR
Q
NY
A
Q-
-
-
D
LQ
L
SIRG
F
G
SRS
T
YGIRGIRLYV
DG
I
P
ATMPDG
--
QG
QT
S
N
I
D
L-
-
----
-
-
---
--
-
SS
VQNV
EVLRGP
F
SALYGN
-
A
S
GGV
M
N
VT
T
Q
T
G
Q
QPPTIEASSYYGSF
GS
W
RY
G
LK
A
TG
A
TG
D
GT
Q
P
---
G
DVDY
TV
S
TT
R
F
TTH
G
--
-
-
-
---Y
R
DH
S
GAQ
K
NL
A
N
A
-------
KLGVRIDDASK
L
S
L
IFNS
V
DIK
A
D
D
P
GG
LT
KA
E
WK
A
NPQQ
A
P
RA
E
QYD
T
R
K
-----
TIK
Q
TQ
A
G
L
R
Y
ER
SL
SSR
-----------------
D
D
M
S
V
M
M
Y
A
-------------
-
-
GERETTQ
Y
QS
I
P
M
----
APQL
N
PSHAGSVIT
L
Q
R
---
HYQ
G
I
D
-
---
-------
-
----
----
S
RWTHR
G
EL
GV
P
V
------
T
F
T
T
G
L
N
Y
ENM
S
EN
R
KGYNNFR
L
NS----
-
--
-
G
MPEYGQKGELRR
D
ER
N
L
MWN
I
DPYLQ
TQWQ
L
SE
K
L
S
L
D
AG
V
RY
SSVWFDSN
DH
------------
YVTP
GN
GDDSGDASYH
K
W
L
P
AGS
L
KYA
M
T
D
A
W
N
I
Y
L
A
AG
RG
FET
P
T
I
N
E
------
L
SYRAD
G
---
--
QS
G
M--
-
-----
-
-
N
F
G
LKP
S
T
N
D
T
I
EIG
SKTRIGD
GL
L
S
-
L
A
L
F
Q
TD
TD
DE
IV
V
-------
D
S
SSGGRTT
Y
K
N
A
GK
T
R
RQ
G
A
E
L
A
WDQ
R
-
FAG
D
FRVNA
S
W
TW
L
DATYRSN
VC
N
EQ
DC
---
N
G
N
----
R
MP
G
I
A
RN
M
G
F
A
S
I
G
Y
VPE
D
GWYAGMEA
R
YM
G
D
IM
A
D--
-
--
----
--
-----
D
EN
T
AKAPS
YTLVGL
FTG
Y
K
Y
N
Y
HNL
T
V
D
L
FGR
VDNLFDK
E
Y
VGSV
I
VNE
S
N
---
----
--
-----
-
-
G
R
---
Y
Y
E
PA
PGRNY
G
VG
VN
fig|562.372.peg.1247
Escherichia coli 1212A (29-694/700)
MIVSA
APQVVSE
L
DT
P
A
A
VSV
V
DG
EE
M
R
L
A
-
TPRI
N
LSE
S
L
T
G
-
VPG
L
Q
V
QNR
Q
NY
A
Q-
-
-
D
LQ
L
SIRG
F
G
SRS
T
YGIRGIRLYV
DG
I
P
ATMPDG
--
QG
QT
S
N
I
D
L-
-
----
-
-
---
--
-
SS
VQNV
EVLRGP
F
SALYGN
-
A
S
GGV
M
N
VT
T
Q
T
G
Q
QPPTIEASSYYGSF
GS
W
RY
G
LK
A
TG
A
TG
D
GT
Q
P
---
G
DVDY
TV
S
TT
R
F
TTH
G
--
-
-
-
---Y
R
DH
S
GAQ
K
NL
A
N
A
-------
KLGVRIDDASK
L
S
L
IFNS
V
DIK
A
D
D
P
GG
LT
KA
E
WK
A
NPQQ
A
P
RA
E
QYD
T
R
K
-----
TIK
Q
TQ
A
G
L
R
Y
ER
SL
SSR
-----------------
D
D
M
S
V
M
M
Y
A
-------------
-
-
GERETTQ
Y
QS
I
P
M
----
APQL
N
PSHAGSVIT
L
Q
R
---
HYQ
G
I
D
-
---
-------
-
----
----
S
RWTHR
G
EL
GV
P
V
------
T
F
T
T
G
L
N
Y
ENM
S
EN
R
KGYNNFR
L
NS----
-
--
-
G
MPEYGQKGELRR
D
ER
N
L
MWN
I
DPYLQ
TQWQ
L
SE
K
L
S
L
D
AG
V
RY
SSVWFDSN
DH
------------
YVTP
GN
GDDSGDASYH
K
W
L
P
AGS
L
KYA
M
T
D
A
W
N
I
Y
L
A
AG
RG
FET
P
T
I
N
E
------
L
SYRAD
G
---
--
QS
G
M--
-
-----
-
-
N
F
G
LKP
S
T
N
D
T
I
EIG
SKTRIGD
GL
L
S
-
L
A
L
F
Q
TD
TD
DE
IV
V
-------
D
S
SSGGRTT
Y
K
N
A
GK
T
R
RQ
G
A
E
L
A
WDQ
R
-
FAG
D
FRVNA
S
W
TW
L
DATYRSN
VC
N
EQ
DC
---
N
G
N
----
R
MP
G
I
A
RN
M
G
F
A
S
I
G
Y
VPE
D
GWYAGMEA
R
YM
G
D
IM
A
D--
-
--
----
--
-----
D
EN
T
AKAPS
YTLVGL
FTG
Y
K
Y
N
Y
HNL
T
V
D
L
FGR
VDNLFDK
E
Y
VGSV
I
VNE
S
N
---
----
--
-----
-
-
G
R
---
Y
Y
E
PA
PGRNY
G
VG
VN
fig|562.374.peg.2338
Escherichia coli 536A (29-694/700)
MIVSA
APQVVSE
L
DT
P
A
A
VSV
V
DG
EE
M
R
L
A
-
TPRI
N
LSE
S
L
T
G
-
VPG
L
Q
V
QNR
Q
NY
A
Q-
-
-
D
LQ
L
SIRG
F
G
SRS
T
YGIRGIRLYV
DG
I
P
ATMPDG
--
QG
QT
S
N
I
D
L-
-
----
-
-
---
--
-
SS
VQNV
EVLRGP
F
SALYGN
-
A
S
GGV
M
N
VT
T
Q
T
G
Q
QPPTIEASSYYGSF
GS
W
RY
G
LK
A
TG
A
TG
D
GT
Q
P
---
G
DVDY
TV
S
TT
R
F
TTH
G
--
-
-
-
---Y
R
DH
S
GAQ
K
NL
A
N
A
-------
KLGVRIDDASK
L
S
L
IFNS
V
DIK
A
D
D
P
GG
LT
KA
E
WK
A
NPQQ
A
P
RA
E
QYD
T
R
K
-----
TIK
Q
TQ
A
G
L
R
Y
ER
SL
SSR
-----------------
D
D
M
S
V
M
M
Y
A
-------------
-
-
GERETTQ
Y
QS
I
P
M
----
APQL
N
PSHAGSVIT
L
Q
R
---
HYQ
G
I
D
-
---
-------
-
----
----
S
RWTHR
G
EL
GV
P
V
------
T
F
T
T
G
L
N
Y
ENM
S
EN
R
KGYNNFR
L
NS----
-
--
-
G
MPEYGQKGELRR
D
ER
N
L
MWN
I
DPYLQ
TQWQ
L
SE
K
L
S
L
D
AG
V
RY
SSVWFDSN
DH
------------
YVTP
GN
GDDSGDASYH
K
W
L
P
AGS
L
KYA
M
T
D
A
W
N
I
Y
L
A
AG
RG
FET
P
T
I
N
E
------
L
SYRAD
G
---
--
QS
G
M--
-
-----
-
-
N
F
G
LKP
S
T
N
D
T
I
EIG
SKTRIGD
GL
L
S
-
L
A
L
F
Q
TD
TD
DE
IV
V
-------
D
S
SSGGRTT
Y
K
N
A
GK
T
R
RQ
G
A
E
L
A
WDQ
R
-
FAG
D
FRVNA
S
W
TW
L
DATYRSN
VC
N
EQ
DC
---
N
G
N
----
R
MP
G
I
A
RN
M
G
F
A
S
I
G
Y
VPE
D
GWYAGMEA
R
YM
G
D
IM
A
D--
-
--
----
--
-----
D
EN
T
AKAPS
YTLVGL
FTG
Y
K
Y
N
Y
HNL
T
V
D
L
FGR
VDNLFDK
E
Y
VGSV
I
VNE
S
N
---
----
--
-----
-
-
G
R
---
Y
Y
E
PA
PGRNY
G
VG
VN
fig|83334.1.peg.2085
Escherichia coli O157:H7 (29-694/700)
MIVSA
APQVVSE
L
DT
P
A
A
VSV
V
DG
EE
M
R
L
A
-
TPRI
N
LSE
S
L
T
G
-
VPG
L
Q
V
QNR
Q
NY
A
Q-
-
-
D
LQ
L
SIRG
F
G
SRS
T
YGIRGIRLYV
DG
I
P
ATMPDG
--
QG
QT
S
N
I
D
L-
-
----
-
-
---
--
-
SS
VQNV
EVLRGP
F
SALYGN
-
A
S
GGV
M
N
VT
T
Q
T
G
Q
QPPTIEASSYYGSF
GS
W
RY
G
LK
A
TG
A
TG
D
GT
Q
P
---
G
DVDY
TV
S
TT
R
F
TTH
G
--
-
-
-
---Y
R
DH
S
GAQ
K
NL
A
N
A
-------
KLGVRIDDASK
L
S
L
IFNS
V
DIK
A
D
D
P
GG
LT
KA
E
WK
A
NPQQ
A
P
RA
E
QYD
T
R
K
-----
TIK
Q
TQ
A
G
L
R
Y
ER
SL
SSR
-----------------
D
D
M
S
V
M
M
Y
A
-------------
-
-
GERETTQ
Y
QS
I
P
M
----
APQL
N
PSHAGSVIT
L
Q
R
---
HYQ
G
I
D
-
---
-------
-
----
----
S
RWTHR
G
EL
GV
P
V
------
T
F
T
T
G
L
N
Y
ENM
S
EN
R
KGYNNFR
L
NS----
-
--
-
G
MPEYGQKGELRR
D
ER
N
L
MWN
I
DPYLQ
TQWQ
L
SE
K
L
S
L
D
AG
V
RY
SSVWFDSN
DH
------------
YVTP
GN
GDDSGDASYH
K
W
L
P
AGS
L
KYA
M
T
D
A
W
N
I
Y
L
A
AG
RG
FET
P
T
I
N
E
------
L
SYRAD
G
---
--
QS
G
M--
-
-----
-
-
N
F
G
LKP
S
T
N
D
T
I
EIG
SKTRIGD
GL
L
S
-
L
A
L
F
Q
TD
TD
DE
IV
V
-------
D
S
SSGGRTT
Y
K
N
A
GK
T
R
RQ
G
A
E
L
A
WDQ
R
-
FAG
D
FRVNA
S
W
TW
L
DATYRSN
VC
N
EQ
DC
---
N
G
N
----
R
MP
G
I
A
RN
M
G
F
A
S
I
G
Y
VPE
D
GWYAGMEA
R
YM
G
D
IM
A
D--
-
--
----
--
-----
D
EN
T
AKAPS
YTLVGL
FTG
Y
K
Y
N
Y
HNL
T
V
D
L
FGR
VDNLFDK
E
Y
VGSV
I
VNE
S
N
---
----
--
-----
-
-
G
R
---
Y
Y
E
PA
PGRNY
G
VG
VN
fig|444454.5.peg.959
Escherichia coli O157:H7 str. EC4024 (29-694/700)
MIVSA
APQVVSE
L
DT
P
A
A
VSV
V
DG
EE
M
R
L
A
-
TPRI
N
LSE
S
L
T
G
-
VPG
L
Q
V
QNR
Q
NY
A
Q-
-
-
D
LQ
L
SIRG
F
G
SRS
T
YGIRGIRLYV
DG
I
P
ATMPDG
--
QG
QT
S
N
I
D
L-
-
----
-
-
---
--
-
SS
VQNV
EVLRGP
F
SALYGN
-
A
S
GGV
M
N
VT
T
Q
T
G
Q
QPPTIEASSYYGSF
GS
W
RY
G
LK
A
TG
A
TG
D
GT
Q
P
---
G
DVDY
TV
S
TT
R
F
TTH
G
--
-
-
-
---Y
R
DH
S
GAQ
K
NL
A
N
A
-------
KLGVRIDDASK
L
S
L
IFNS
V
DIK
A
D
D
P
GG
LT
KA
E
WK
A
NPQQ
A
P
RA
E
QYD
T
R
K
-----
TIK
Q
TQ
A
G
L
R
Y
ER
SL
SSR
-----------------
D
D
M
S
V
M
M
Y
A
-------------
-
-
GERETTQ
Y
QS
I
P
M
----
APQL
N
PSHAGSVIT
L
Q
R
---
HYQ
G
I
D
-
---
-------
-
----
----
S
RWTHR
G
EL
GV
P
V
------
T
F
T
T
G
L
N
Y
ENM
S
EN
R
KGYNNFR
L
NS----
-
--
-
G
MPEYGQKGELRR
D
ER
N
L
MWN
I
DPYLQ
TQWQ
L
SE
K
L
S
L
D
AG
V
RY
SSVWFDSN
DH
------------
YVTP
GN
GDDSGDASYH
K
W
L
P
AGS
L
KYA
M
T
D
A
W
N
I
Y
L
A
AG
RG
FET
P
T
I
N
E
------
L
SYRAD
G
---
--
QS
G
M--
-
-----
-
-
N
F
G
LKP
S
T
N
D
T
I
EIG
SKTRIGD
GL
L
S
-
L
A
L
F
Q
TD
TD
DE
IV
V
-------
D
S
SSGGRTT
Y
K
N
A
GK
T
R
RQ
G
A
E
L
A
WDQ
R
-
FAG
D
FRVNA
S
W
TW
L
DATYRSN
VC
N
EQ
DC
---
N
G
N
----
R
MP
G
I
A
RN
M
G
F
A
S
I
G
Y
VPE
D
GWYAGMEA
R
YM
G
D
IM
A
D--
-
--
----
--
-----
D
EN
T
AKAPS
YTLVGL
FTG
Y
K
Y
N
Y
HNL
T
V
D
L
FGR
VDNLFDK
E
Y
VGSV
I
VNE
S
N
---
----
--
-----
-
-
G
R
---
Y
Y
E
PA
PGRNY
G
VG
VN
fig|444449.5.peg.286
Escherichia coli O157:H7 str. EC4042 (29-694/700)
MIVSA
APQVVSE
L
DT
P
A
A
VSV
V
DG
EE
M
R
L
A
-
TPRI
N
LSE
S
L
T
G
-
VPG
L
Q
V
QNR
Q
NY
A
Q-
-
-
D
LQ
L
SIRG
F
G
SRS
T
YGIRGIRLYV
DG
I
P
ATMPDG
--
QG
QT
S
N
I
D
L-
-
----
-
-
---
--
-
SS
VQNV
EVLRGP
F
SALYGN
-
A
S
GGV
M
N
VT
T
Q
T
G
Q
QPPTIEASSYYGSF
GS
W
RY
G
LK
A
TG
A
TG
D
GT
Q
P
---
G
DVDY
TV
S
TT
R
F
TTH
G
--
-
-
-
---Y
R
DH
S
GAQ
K
NL
A
N
A
-------
KLGVRIDDASK
L
S
L
IFNS
V
DIK
A
D
D
P
GG
LT
KA
E
WK
A
NPQQ
A
P
RA
E
QYD
T
R
K
-----
TIK
Q
TQ
A
G
L
R
Y
ER
SL
SSR
-----------------
D
D
M
S
V
M
M
Y
A
-------------
-
-
GERETTQ
Y
QS
I
P
M
----
APQL
N
PSHAGSVIT
L
Q
R
---
HYQ
G
I
D
-
---
-------
-
----
----
S
RWTHR
G
EL
GV
P
V
------
T
F
T
T
G
L
N
Y
ENM
S
EN
R
KGYNNFR
L
NS----
-
--
-
G
MPEYGQKGELRR
D
ER
N
L
MWN
I
DPYLQ
TQWQ
L
SE
K
L
S
L
D
AG
V
RY
SSVWFDSN
DH
------------
YVTP
GN
GDDSGDASYH
K
W
L
P
AGS
L
KYA
M
T
D
A
W
N
I
Y
L
A
AG
RG
FET
P
T
I
N
E
------
L
SYRAD
G
---
--
QS
G
M--
-
-----
-
-
N
F
G
LKP
S
T
N
D
T
I
EIG
SKTRIGD
GL
L
S
-
L
A
L
F
Q
TD
TD
DE
IV
V
-------
D
S
SSGGRTT
Y
K
N
A
GK
T
R
RQ
G
A
E
L
A
WDQ
R
-
FAG
D
FRVNA
S
W
TW
L
DATYRSN
VC
N
EQ
DC
---
N
G
N
----
R
MP
G
I
A
RN
M
G
F
A
S
I
G
Y
VPE
D
GWYAGMEA
R
YM
G
D
IM
A
D--
-
--
----
--
-----
D
EN
T
AKAPS
YTLVGL
FTG
Y
K
Y
N
Y
HNL
T
V
D
L
FGR
VDNLFDK
E
Y
VGSV
I
VNE
S
N
---
----
--
-----
-
-
G
R
---
Y
Y
E
PA
PGRNY
G
VG
VN
fig|444448.5.peg.4642
Escherichia coli O157:H7 str. EC4045 (29-694/700)
MIVSA
APQVVSE
L
DT
P
A
A
VSV
V
DG
EE
M
R
L
A
-
TPRI
N
LSE
S
L
T
G
-
VPG
L
Q
V
QNR
Q
NY
A
Q-
-
-
D
LQ
L
SIRG
F
G
SRS
T
YGIRGIRLYV
DG
I
P
ATMPDG
--
QG
QT
S
N
I
D
L-
-
----
-
-
---
--
-
SS
VQNV
EVLRGP
F
SALYGN
-
A
S
GGV
M
N
VT
T
Q
T
G
Q
QPPTIEASSYYGSF
GS
W
RY
G
LK
A
TG
A
TG
D
GT
Q
P
---
G
DVDY
TV
S
TT
R
F
TTH
G
--
-
-
-
---Y
R
DH
S
GAQ
K
NL
A
N
A
-------
KLGVRIDDASK
L
S
L
IFNS
V
DIK
A
D
D
P
GG
LT
KA
E
WK
A
NPQQ
A
P
RA
E
QYD
T
R
K
-----
TIK
Q
TQ
A
G
L
R
Y
ER
SL
SSR
-----------------
D
D
M
S
V
M
M
Y
A
-------------
-
-
GERETTQ
Y
QS
I
P
M
----
APQL
N
PSHAGSVIT
L
Q
R
---
HYQ
G
I
D
-
---
-------
-
----
----
S
RWTHR
G
EL
GV
P
V
------
T
F
T
T
G
L
N
Y
ENM
S
EN
R
KGYNNFR
L
NS----
-
--
-
G
MPEYGQKGELRR
D
ER
N
L
MWN
I
DPYLQ
TQWQ
L
SE
K
L
S
L
D
AG
V
RY
SSVWFDSN
DH
------------
YVTP
GN
GDDSGDASYH
K
W
L
P
AGS
L
KYA
M
T
D
A
W
N
I
Y
L
A
AG
RG
FET
P
T
I
N
E
------
L
SYRAD
G
---
--
QS
G
M--
-
-----
-
-
N
F
G
LKP
S
T
N
D
T
I
EIG
SKTRIGD
GL
L
S
-
L
A
L
F
Q
TD
TD
DE
IV
V
-------
D
S
SSGGRTT
Y
K
N
A
GK
T
R
RQ
G
A
E
L
A
WDQ
R
-
FAG
D
FRVNA
S
W
TW
L
DATYRSN
VC
N
EQ
DC
---
N
G
N
----
R
MP
G
I
A
RN
M
G
F
A
S
I
G
Y
VPE
D
GWYAGMEA
R
YM
G
D
IM
A
D--
-
--
----
--
-----
D
EN
T
AKAPS
YTLVGL
FTG
Y
K
Y
N
Y
HNL
T
V
D
L
FGR
VDNLFDK
E
Y
VGSV
I
VNE
S
N
---
----
--
-----
-
-
G
R
---
Y
Y
E
PA
PGRNY
G
VG
VN
fig|444453.5.peg.2838
Escherichia coli O157:H7 str. EC4076 (29-694/700)
MIVSA
APQVVSE
L
DT
P
A
A
VSV
V
DG
EE
M
R
L
A
-
TPRI
N
LSE
S
L
T
G
-
VPG
L
Q
V
QNR
Q
NY
A
Q-
-
-
D
LQ
L
SIRG
F
G
SRS
T
YGIRGIRLYV
DG
I
P
ATMPDG
--
QG
QT
S
N
I
D
L-
-
----
-
-
---
--
-
SS
VQNV
EVLRGP
F
SALYGN
-
A
S
GGV
M
N
VT
T
Q
T
G
Q
QPPTIEASSYYGSF
GS
W
RY
G
LK
A
TG
A
TG
D
GT
Q
P
---
G
DVDY
TV
S
TT
R
F
TTH
G
--
-
-
-
---Y
R
DH
S
GAQ
K
NL
A
N
A
-------
KLGVRIDDASK
L
S
L
IFNS
V
DIK
A
D
D
P
GG
LT
KA
E
WK
A
NPQQ
A
P
RA
E
QYD
T
R
K
-----
TIK
Q
TQ
A
G
L
R
Y
ER
SL
SSR
-----------------
D
D
M
S
V
M
M
Y
A
-------------
-
-
GERETTQ
Y
QS
I
P
M
----
APQL
N
PSHAGSVIT
L
Q
R
---
HYQ
G
I
D
-
---
-------
-
----
----
S
RWTHR
G
EL
GV
P
V
------
T
F
T
T
G
L
N
Y
ENM
S
EN
R
KGYNNFR
L
NS----
-
--
-
G
MPEYGQKGELRR
D
ER
N
L
MWN
I
DPYLQ
TQWQ
L
SE
K
L
S
L
D
AG
V
RY
SSVWFDSN
DH
------------
YVTP
GN
GDDSGDASYH
K
W
L
P
AGS
L
KYA
M
T
D
A
W
N
I
Y
L
A
AG
RG
FET
P
T
I
N
E
------
L
SYRAD
G
---
--
QS
G
M--
-
-----
-
-
N
F
G
LKP
S
T
N
D
T
I
EIG
SKTRIGD
GL
L
S
-
L
A
L
F
Q
TD
TD
DE
IV
V
-------
D
S
SSGGRTT
Y
K
N
A
GK
T
R
RQ
G
A
E
L
A
WDQ
R
-
FAG
D
FRVNA
S
W
TW
L
DATYRSN
VC
N
EQ
DC
---
N
G
N
----
R
MP
G
I
A
RN
M
G
F
A
S
I
G
Y
VPE
D
GWYAGMEA
R
YM
G
D
IM
A
D--
-
--
----
--
-----
D
EN
T
AKAPS
YTLVGL
FTG
Y
K
Y
N
Y
HNL
T
V
D
L
FGR
VDNLFDK
E
Y
VGSV
I
VNE
S
N
---
----
--
-----
-
-
G
R
---
Y
Y
E
PA
PGRNY
G
VG
VN
fig|444452.5.peg.1979
Escherichia coli O157:H7 str. EC4113 (29-694/700)
MIVSA
APQVVSE
L
DT
P
A
A
VSV
V
DG
EE
M
R
L
A
-
TPRI
N
LSE
S
L
T
G
-
VPG
L
Q
V
QNR
Q
NY
A
Q-
-
-
D
LQ
L
SIRG
F
G
SRS
T
YGIRGIRLYV
DG
I
P
ATMPDG
--
QG
QT
S
N
I
D
L-
-
----
-
-
---
--
-
SS
VQNV
EVLRGP
F
SALYGN
-
A
S
GGV
M
N
VT
T
Q
T
G
Q
QPPTIEASSYYGSF
GS
W
RY
G
LK
A
TG
A
TG
D
GT
Q
P
---
G
DVDY
TV
S
TT
R
F
TTH
G
--
-
-
-
---Y
R
DH
S
GAQ
K
NL
A
N
A
-------
KLGVRIDDASK
L
S
L
IFNS
V
DIK
A
D
D
P
GG
LT
KA
E
WK
A
NPQQ
A
P
RA
E
QYD
T
R
K
-----
TIK
Q
TQ
A
G
L
R
Y
ER
SL
SSR
-----------------
D
D
M
S
V
M
M
Y
A
-------------
-
-
GERETTQ
Y
QS
I
P
M
----
APQL
N
PSHAGSVIT
L
Q
R
---
HYQ
G
I
D
-
---
-------
-
----
----
S
RWTHR
G
EL
GV
P
V
------
T
F
T
T
G
L
N
Y
ENM
S
EN
R
KGYNNFR
L
NS----
-
--
-
G
MPEYGQKGELRR
D
ER
N
L
MWN
I
DPYLQ
TQWQ
L
SE
K
L
S
L
D
AG
V
RY
SSVWFDSN
DH
------------
YVTP
GN
GDDSGDASYH
K
W
L
P
AGS
L
KYA
M
T
D
A
W
N
I
Y
L
A
AG
RG
FET
P
T
I
N
E
------
L
SYRAD
G
---
--
QS
G
M--
-
-----
-
-
N
F
G
LKP
S
T
N
D
T
I
EIG
SKTRIGD
GL
L
S
-
L
A
L
F
Q
TD
TD
DE
IV
V
-------
D
S
SSGGRTT
Y
K
N
A
GK
T
R
RQ
G
A
E
L
A
WDQ
R
-
FAG
D
FRVNA
S
W
TW
L
DATYRSN
VC
N
EQ
DC
---
N
G
N
----
R
MP
G
I
A
RN
M
G
F
A
S
I
G
Y
VPE
D
GWYAGMEA
R
YM
G
D
IM
A
D--
-
--
----
--
-----
D
EN
T
AKAPS
YTLVGL
FTG
Y
K
Y
N
Y
HNL
T
V
D
L
FGR
VDNLFDK
E
Y
VGSV
I
VNE
S
N
---
----
--
-----
-
-
G
R
---
Y
Y
E
PA
PGRNY
G
VG
VN
fig|444450.8.peg.2104
Escherichia coli O157:H7 str. EC4115 (29-694/700)
MIVSA
APQVVSE
L
DT
P
A
A
VSV
V
DG
EE
M
R
L
A
-
TPRI
N
LSE
S
L
T
G
-
VPG
L
Q
V
QNR
Q
NY
A
Q-
-
-
D
LQ
L
SIRG
F
G
SRS
T
YGIRGIRLYV
DG
I
P
ATMPDG
--
QG
QT
S
N
I
D
L-
-
----
-
-
---
--
-
SS
VQNV
EVLRGP
F
SALYGN
-
A
S
GGV
M
N
VT
T
Q
T
G
Q
QPPTIEASSYYGSF
GS
W
RY
G
LK
A
TG
A
TG
D
GT
Q
P
---
G
DVDY
TV
S
TT
R
F
TTH
G
--
-
-
-
---Y
R
DH
S
GAQ
K
NL
A
N
A
-------
KLGVRIDDASK
L
S
L
IFNS
V
DIK
A
D
D
P
GG
LT
KA
E
WK
A
NPQQ
A
P
RA
E
QYD
T
R
K
-----
TIK
Q
TQ
A
G
L
R
Y
ER
SL
SSR
-----------------
D
D
M
S
V
M
M
Y
A
-------------
-
-
GERETTQ
Y
QS
I
P
M
----
APQL
N
PSHAGSVIT
L
Q
R
---
HYQ
G
I
D
-
---
-------
-
----
----
S
RWTHR
G
EL
GV
P
V
------
T
F
T
T
G
L
N
Y
ENM
S
EN
R
KGYNNFR
L
NS----
-
--
-
G
MPEYGQKGELRR
D
ER
N
L
MWN
I
DPYLQ
TQWQ
L
SE
K
L
S
L
D
AG
V
RY
SSVWFDSN
DH
------------
YVTP
GN
GDDSGDASYH
K
W
L
P
AGS
L
KYA
M
T
D
A
W
N
I
Y
L
A
AG
RG
FET
P
T
I
N
E
------
L
SYRAD
G
---
--
QS
G
M--
-
-----
-
-
N
F
G
LKP
S
T
N
D
T
I
EIG
SKTRIGD
GL
L
S
-
L
A
L
F
Q
TD
TD
DE
IV
V
-------
D
S
SSGGRTT
Y
K
N
A
GK
T
R
RQ
G
A
E
L
A
WDQ
R
-
FAG
D
FRVNA
S
W
TW
L
DATYRSN
VC
N
EQ
DC
---
N
G
N
----
R
MP
G
I
A
RN
M
G
F
A
S
I
G
Y
VPE
D
GWYAGMEA
R
YM
G
D
IM
A
D--
-
--
----
--
-----
D
EN
T
AKAPS
YTLVGL
FTG
Y
K
Y
N
Y
HNL
T
V
D
L
FGR
VDNLFDK
E
Y
VGSV
I
VNE
S
N
---
----
--
-----
-
-
G
R
---
Y
Y
E
PA
PGRNY
G
VG
VN
fig|444451.5.peg.1970
Escherichia coli O157:H7 str. EC4196 (29-694/700)
MIVSA
APQVVSE
L
DT
P
A
A
VSV
V
DG
EE
M
R
L
A
-
TPRI
N
LSE
S
L
T
G
-
VPG
L
Q
V
QNR
Q
NY
A
Q-
-
-
D
LQ
L
SIRG
F
G
SRS
T
YGIRGIRLYV
DG
I
P
ATMPDG
--
QG
QT
S
N
I
D
L-
-
----
-
-
---
--
-
SS
VQNV
EVLRGP
F
SALYGN
-
A
S
GGV
M
N
VT
T
Q
T
G
Q
QPPTIEASSYYGSF
GS
W
RY
G
LK
A
TG
A
TG
D
GT
Q
P
---
G
DVDY
TV
S
TT
R
F
TTH
G
--
-
-
-
---Y
R
DH
S
GAQ
K
NL
A
N
A
-------
KLGVRIDDASK
L
S
L
IFNS
V
DIK
A
D
D
P
GG
LT
KA
E
WK
A
NPQQ
A
P
RA
E
QYD
T
R
K
-----
TIK
Q
TQ
A
G
L
R
Y
ER
SL
SSR
-----------------
D
D
M
S
V
M
M
Y
A
-------------
-
-
GERETTQ
Y
QS
I
P
M
----
APQL
N
PSHAGSVIT
L
Q
R
---
HYQ
G
I
D
-
---
-------
-
----
----
S
RWTHR
G
EL
GV
P
V
------
T
F
T
T
G
L
N
Y
ENM
S
EN
R
KGYNNFR
L
NS----
-
--
-
G
MPEYGQKGELRR
D
ER
N
L
MWN
I
DPYLQ
TQWQ
L
SE
K
L
S
L
D
AG
V
RY
SSVWFDSN
DH
------------
YVTP
GN
GDDSGDASYH
K
W
L
P
AGS
L
KYA
M
T
D
A
W
N
I
Y
L
A
AG
RG
FET
P
T
I
N
E
------
L
SYRAD
G
---
--
QS
G
M--
-
-----
-
-
N
F
G
LKP
S
T
N
D
T
I
EIG
SKTRIGD
GL
L
S
-
L
A
L
F
Q
TD
TD
DE
IV
V
-------
D
S
SSGGRTT
Y
K
N
A
GK
T
R
RQ
G
A
E
L
A
WDQ
R
-
FAG
D
FRVNA
S
W
TW
L
DATYRSN
VC
N
EQ
DC
---
N
G
N
----
R
MP
G
I
A
RN
M
G
F
A
S
I
G
Y
VPE
D
GWYAGMEA
R
YM
G
D
IM
A
D--
-
--
----
--
-----
D
EN
T
AKAPS
YTLVGL
FTG
Y
K
Y
N
Y
HNL
T
V
D
L
FGR
VDNLFDK
E
Y
VGSV
I
VNE
S
N
---
----
--
-----
-
-
G
R
---
Y
Y
E
PA
PGRNY
G
VG
VN
fig|444447.5.peg.5553
Escherichia coli O157:H7 str. EC4206 (29-694/700)
MIVSA
APQVVSE
L
DT
P
A
A
VSV
V
DG
EE
M
R
L
A
-
TPRI
N
LSE
S
L
T
G
-
VPG
L
Q
V
QNR
Q
NY
A
Q-
-
-
D
LQ
L
SIRG
F
G
SRS
T
YGIRGIRLYV
DG
I
P
ATMPDG
--
QG
QT
S
N
I
D
L-
-
----
-
-
---
--
-
SS
VQNV
EVLRGP
F
SALYGN
-
A
S
GGV
M
N
VT
T
Q
T
G
Q
QPPTIEASSYYGSF
GS
W
RY
G
LK
A
TG
A
TG
D
GT
Q
P
---
G
DVDY
TV
S
TT
R
F
TTH
G
--
-
-
-
---Y
R
DH
S
GAQ
K
NL
A
N
A
-------
KLGVRIDDASK
L
S
L
IFNS
V
DIK
A
D
D
P
GG
LT
KA
E
WK
A
NPQQ
A
P
RA
E
QYD
T
R
K
-----
TIK
Q
TQ
A
G
L
R
Y
ER
SL
SSR
-----------------
D
D
M
S
V
M
M
Y
A
-------------
-
-
GERETTQ
Y
QS
I
P
M
----
APQL
N
PSHAGSVIT
L
Q
R
---
HYQ
G
I
D
-
---
-------
-
----
----
S
RWTHR
G
EL
GV
P
V
------
T
F
T
T
G
L
N
Y
ENM
S
EN
R
KGYNNFR
L
NS----
-
--
-
G
MPEYGQKGELRR
D
ER
N
L
MWN
I
DPYLQ
TQWQ
L
SE
K
L
S
L
D
AG
V
RY
SSVWFDSN
DH
------------
YVTP
GN
GDDSGDASYH
K
W
L
P
AGS
L
KYA
M
T
D
A
W
N
I
Y
L
A
AG
RG
FET
P
T
I
N
E
------
L
SYRAD
G
---
--
QS
G
M--
-
-----
-
-
N
F
G
LKP
S
T
N
D
T
I
EIG
SKTRIGD
GL
L
S
-
L
A
L
F
Q
TD
TD
DE
IV
V
-------
D
S
SSGGRTT
Y
K
N
A
GK
T
R
RQ
G
A
E
L
A
WDQ
R
-
FAG
D
FRVNA
S
W
TW
L
DATYRSN
VC
N
EQ
DC
---
N
G
N
----
R
MP
G
I
A
RN
M
G
F
A
S
I
G
Y
VPE
D
GWYAGMEA
R
YM
G
D
IM
A
D--
-
--
----
--
-----
D
EN
T
AKAPS
YTLVGL
FTG
Y
K
Y
N
Y
HNL
T
V
D
L
FGR
VDNLFDK
E
Y
VGSV
I
VNE
S
N
---
----
--
-----
-
-
G
R
---
Y
Y
E
PA
PGRNY
G
VG
VN
fig|478004.5.peg.2829
Escherichia coli O157:H7 str. EC4401 (29-694/700)
MIVSA
APQVVSE
L
DT
P
A
A
VSV
V
DG
EE
M
R
L
A
-
TPRI
N
LSE
S
L
T
G
-
VPG
L
Q
V
QNR
Q
NY
A
Q-
-
-
D
LQ
L
SIRG
F
G
SRS
T
YGIRGIRLYV
DG
I
P
ATMPDG
--
QG
QT
S
N
I
D
L-
-
----
-
-
---
--
-
SS
VQNV
EVLRGP
F
SALYGN
-
A
S
GGV
M
N
VT
T
Q
T
G
Q
QPPTIEASSYYGSF
GS
W
RY
G
LK
A
TG
A
TG
D
GT
Q
P
---
G
DVDY
TV
S
TT
R
F
TTH
G
--
-
-
-
---Y
R
DH
S
GAQ
K
NL
A
N
A
-------
KLGVRIDDASK
L
S
L
IFNS
V
DIK
A
D
D
P
GG
LT
KA
E
WK
A
NPQQ
A
P
RA
E
QYD
T
R
K
-----
TIK
Q
TQ
A
G
L
R
Y
ER
SL
SSR
-----------------
D
D
M
S
V
M
M
Y
A
-------------
-
-
GERETTQ
Y
QS
I
P
M
----
APQL
N
PSHAGSVIT
L
Q
R
---
HYQ
G
I
D
-
---
-------
-
----
----
S
RWTHR
G
EL
GV
P
V
------
T
F
T
T
G
L
N
Y
ENM
S
EN
R
KGYNNFR
L
NS----
-
--
-
G
MPEYGQKGELRR
D
ER
N
L
MWN
I
DPYLQ
TQWQ
L
SE
K
L
S
L
D
AG
V
RY
SSVWFDSN
DH
------------
YVTP
GN
GDDSGDASYH
K
W
L
P
AGS
L
KYA
M
T
D
A
W
N
I
Y
L
A
AG
RG
FET
P
T
I
N
E
------
L
SYRAD
G
---
--
QS
G
M--
-
-----
-
-
N
F
G
LKP
S
T
N
D
T
I
EIG
SKTRIGD
GL
L
S
-
L
A
L
F
Q
TD
TD
DE
IV
V
-------
D
S
SSGGRTT
Y
K
N
A
GK
T
R
RQ
G
A
E
L
A
WDQ
R
-
FAG
D
FRVNA
S
W
TW
L
DATYRSN
VC
N
EQ
DC
---
N
G
N
----
R
MP
G
I
A
RN
M
G
F
A
S
I
G
Y
VPE
D
GWYAGMEA
R
YM
G
D
IM
A
D--
-
--
----
--
-----
D
EN
T
AKAPS
YTLVGL
FTG
Y
K
Y
N
Y
HNL
T
V
D
L
FGR
VDNLFDK
E
Y
VGSV
I
VNE
S
N
---
----
--
-----
-
-
G
R
---
Y
Y
E
PA
PGRNY
G
VG
VN
fig|478005.5.peg.2991
Escherichia coli O157:H7 str. EC4486 (29-694/700)
MIVSA
APQVVSE
L
DT
P
A
A
VSV
V
DG
EE
M
R
L
A
-
TPRI
N
LSE
S
L
T
G
-
VPG
L
Q
V
QNR
Q
NY
A
Q-
-
-
D
LQ
L
SIRG
F
G
SRS
T
YGIRGIRLYV
DG
I
P
ATMPDG
--
QG
QT
S
N
I
D
L-
-
----
-
-
---
--
-
SS
VQNV
EVLRGP
F
SALYGN
-
A
S
GGV
M
N
VT
T
Q
T
G
Q
QPPTIEASSYYGSF
GS
W
RY
G
LK
A
TG
A
TG
D
GT
Q
P
---
G
DVDY
TV
S
TT
R
F
TTH
G
--
-
-
-
---Y
R
DH
S
GAQ
K
NL
A
N
A
-------
KLGVRIDDASK
L
S
L
IFNS
V
DIK
A
D
D
P
GG
LT
KA
E
WK
A
NPQQ
A
P
RA
E
QYD
T
R
K
-----
TIK
Q
TQ
A
G
L
R
Y
ER
SL
SSR
-----------------
D
D
M
S
V
M
M
Y
A
-------------
-
-
GERETTQ
Y
QS
I
P
M
----
APQL
N
PSHAGSVIT
L
Q
R
---
HYQ
G
I
D
-
---
-------
-
----
----
S
RWTHR
G
EL
GV
P
V
------
T
F
T
T
G
L
N
Y
ENM
S
EN
R
KGYNNFR
L
NS----
-
--
-
G
MPEYGQKGELRR
D
ER
N
L
MWN
I
DPYLQ
TQWQ
L
SE
K
L
S
L
D
AG
V
RY
SSVWFDSN
DH
------------
YVTP
GN
GDDSGDASYH
K
W
L
P
AGS
L
KYA
M
T
D
A
W
N
I
Y
L
A
AG
RG
FET
P
T
I
N
E
------
L
SYRAD
G
---
--
QS
G
M--
-
-----
-
-
N
F
G
LKP
S
T
N
D
T
I
EIG
SKTRIGD
GL
L
S
-
L
A
L
F
Q
TD
TD
DE
IV
V
-------
D
S
SSGGRTT
Y
K
N
A
GK
T
R
RQ
G
A
E
L
A
WDQ
R
-
FAG
D
FRVNA
S
W
TW
L
DATYRSN
VC
N
EQ
DC
---
N
G
N
----
R
MP
G
I
A
RN
M
G
F
A
S
I
G
Y
VPE
D
GWYAGMEA
R
YM
G
D
IM
A
D--
-
--
----
--
-----
D
EN
T
AKAPS
YTLVGL
FTG
Y
K
Y
N
Y
HNL
T
V
D
L
FGR
VDNLFDK
E
Y
VGSV
I
VNE
S
N
---
----
--
-----
-
-
G
R
---
Y
Y
E
PA
PGRNY
G
VG
VN
fig|478006.5.peg.1961
Escherichia coli O157:H7 str. EC4501 (29-694/700)
MIVSA
APQVVSE
L
DT
P
A
A
VSV
V
DG
EE
M
R
L
A
-
TPRI
N
LSE
S
L
T
G
-
VPG
L
Q
V
QNR
Q
NY
A
Q-
-
-
D
LQ
L
SIRG
F
G
SRS
T
YGIRGIRLYV
DG
I
P
ATMPDG
--
QG
QT
S
N
I
D
L-
-
----
-
-
---
--
-
SS
VQNV
EVLRGP
F
SALYGN
-
A
S
GGV
M
N
VT
T
Q
T
G
Q
QPPTIEASSYYGSF
GS
W
RY
G
LK
A
TG
A
TG
D
GT
Q
P
---
G
DVDY
TV
S
TT
R
F
TTH
G
--
-
-
-
---Y
R
DH
S
GAQ
K
NL
A
N
A
-------
KLGVRIDDASK
L
S
L
IFNS
V
DIK
A
D
D
P
GG
LT
KA
E
WK
A
NPQQ
A
P
RA
E
QYD
T
R
K
-----
TIK
Q
TQ
A
G
L
R
Y
ER
SL
SSR
-----------------
D
D
M
S
V
M
M
Y
A
-------------
-
-
GERETTQ
Y
QS
I
P
M
----
APQL
N
PSHAGSVIT
L
Q
R
---
HYQ
G
I
D
-
---
-------
-
----
----
S
RWTHR
G
EL
GV
P
V
------
T
F
T
T
G
L
N
Y
ENM
S
EN
R
KGYNNFR
L
NS----
-
--
-
G
MPEYGQKGELRR
D
ER
N
L
MWN
I
DPYLQ
TQWQ
L
SE
K
L
S
L
D
AG
V
RY
SSVWFDSN
DH
------------
YVTP
GN
GDDSGDASYH
K
W
L
P
AGS
L
KYA
M
T
D
A
W
N
I
Y
L
A
AG
RG
FET
P
T
I
N
E
------
L
SYRAD
G
---
--
QS
G
M--
-
-----
-
-
N
F
G
LKP
S
T
N
D
T
I
EIG
SKTRIGD
GL
L
S
-
L
A
L
F
Q
TD
TD
DE
IV
V
-------
D
S
SSGGRTT
Y
K
N
A
GK
T
R
RQ
G
A
E
L
A
WDQ
R
-
FAG
D
FRVNA
S
W
TW
L
DATYRSN
VC
N
EQ
DC
---
N
G
N
----
R
MP
G
I
A
RN
M
G
F
A
S
I
G
Y
VPE
D
GWYAGMEA
R
YM
G
D
IM
A
D--
-
--
----
--
-----
D
EN
T
AKAPS
YTLVGL
FTG
Y
K
Y
N
Y
HNL
T
V
D
L
FGR
VDNLFDK
E
Y
VGSV
I
VNE
S
N
---
----
--
-----
-
-
G
R
---
Y
Y
E
PA
PGRNY
G
VG
VN
fig|478007.5.peg.2165
Escherichia coli O157:H7 str. EC508 (29-694/700)
MIVSA
APQVVSE
L
DT
P
A
A
VSV
V
DG
EE
M
R
L
A
-
TPRI
N
LSE
S
L
T
G
-
VPG
L
Q
V
QNR
Q
NY
A
Q-
-
-
D
LQ
L
SIRG
F
G
SRS
T
YGIRGIRLYV
DG
I
P
ATMPDG
--
QG
QT
S
N
I
D
L-
-
----
-
-
---
--
-
SS
VQNV
EVLRGP
F
SALYGN
-
A
S
GGV
M
N
VT
T
Q
T
G
Q
QPPTIEASSYYGSF
GS
W
RY
G
LK
A
TG
A
TG
D
GT
Q
P
---
G
DVDY
TV
S
TT
R
F
TTH
G
--
-
-
-
---Y
R
DH
S
GAQ
K
NL
A
N
A
-------
KLGVRIDDASK
L
S
L
IFNS
V
DIK
A
D
D
P
GG
LT
KA
E
WK
A
NPQQ
A
P
RA
E
QYD
T
R
K
-----
TIK
Q
TQ
A
G
L
R
Y
ER
SL
SSR
-----------------
D
D
M
S
V
M
M
Y
A
-------------
-
-
GERETTQ
Y
QS
I
P
M
----
APQL
N
PSHAGSVIT
L
Q
R
---
HYQ
G
I
D
-
---
-------
-
----
----
S
RWTHR
G
EL
GV
P
V
------
T
F
T
T
G
L
N
Y
ENM
S
EN
R
KGYNNFR
L
NS----
-
--
-
G
MPEYGQKGELRR
D
ER
N
L
MWN
I
DPYLQ
TQWQ
L
SE
K
L
S
L
D
AG
V
RY
SSVWFDSN
DH
------------
YVTP
GN
GDDSGDASYH
K
W
L
P
AGS
L
KYA
M
T
D
A
W
N
I
Y
L
A
AG
RG
FET
P
T
I
N
E
------
L
SYRAD
G
---
--
QS
G
M--
-
-----
-
-
N
F
G
LKP
S
T
N
D
T
I
EIG
SKTRIGD
GL
L
S
-
L
A
L
F
Q
TD
TD
DE
IV
V
-------
D
S
SSGGRTT
Y
K
N
A
GK
T
R
RQ
G
A
E
L
A
WDQ
R
-
FAG
D
FRVNA
S
W
TW
L
DATYRSN
VC
N
EQ
DC
---
N
G
N
----
R
MP
G
I
A
RN
M
G
F
A
S
I
G
Y
VPE
D
GWYAGMEA
R
YM
G
D
IM
A
D--
-
--
----
--
-----
D
EN
T
AKAPS
YTLVGL
FTG
Y
K
Y
N
Y
HNL
T
V
D
L
FGR
VDNLFDK
E
Y
VGSV
I
VNE
S
N
---
----
--
-----
-
-
G
R
---
Y
Y
E
PA
PGRNY
G
VG
VN
fig|478008.5.peg.3685
Escherichia coli O157:H7 str. EC869 (29-694/700)
MIVSA
APQVVSE
L
DT
P
A
A
VSV
V
DG
EE
M
R
L
A
-
TPRI
N
LSE
S
L
T
G
-
VPG
L
Q
V
QNR
Q
NY
A
Q-
-
-
D
LQ
L
SIRG
F
G
SRS
T
YGIRGIRLYV
DG
I
P
ATMPDG
--
QG
QT
S
N
I
D
L-
-
----
-
-
---
--
-
SS
VQNV
EVLRGP
F
SALYGN
-
A
S
GGV
M
N
VT
T
Q
T
G
Q
QPPTIEASSYYGSF
GS
W
RY
G
LK
A
TG
A
TG
D
GT
Q
P
---
G
DVDY
TV
S
TT
R
F
TTH
G
--
-
-
-
---Y
R
DH
S
GAQ
K
NL
A
N
A
-------
KLGVRIDDASK
L
S
L
IFNS
V
DIK
A
D
D
P
GG
LT
KA
E
WK
A
NPQQ
A
P
RA
E
QYD
T
R
K
-----
TIK
Q
TQ
A
G
L
R
Y
ER
SL
SSR
-----------------
D
D
M
S
V
M
M
Y
A
-------------
-
-
GERETTQ
Y
QS
I
P
M
----
APQL
N
PSHAGSVIT
L
Q
R
---
HYQ
G
I
D
-
---
-------
-
----
----
S
RWTHR
G
EL
GV
P
V
------
T
F
T
T
G
L
N
Y
ENM
S
EN
R
KGYNNFR
L
NS----
-
--
-
G
MPEYGQKGELRR
D
ER
N
L
MWN
I
DPYLQ
TQWQ
L
SE
K
L
S
L
D
AG
V
RY
SSVWFDSN
DH
------------
YVTP
GN
GDDSGDASYH
K
W
L
P
AGS
L
KYA
M
T
D
A
W
N
I
Y
L
A
AG
RG
FET
P
T
I
N
E
------
L
SYRAD
G
---
--
QS
G
M--
-
-----
-
-
N
F
G
LKP
S
T
N
D
T
I
EIG
SKTRIGD
GL
L
S
-
L
A
L
F
Q
TD
TD
DE
IV
V
-------
D
S
SSGGRTT
Y
K
N
A
GK
T
R
RQ
G
A
E
L
A
WDQ
R
-
FAG
D
FRVNA
S
W
TW
L
DATYRSN
VC
N
EQ
DC
---
N
G
N
----
R
MP
G
I
A
RN
M
G
F
A
S
I
G
Y
VPE
D
GWYAGMEA
R
YM
G
D
IM
A
D--
-
--
----
--
-----
D
EN
T
AKAPS
YTLVGL
FTG
Y
K
Y
N
Y
HNL
T
V
D
L
FGR
VDNLFDK
E
Y
VGSV
I
VNE
S
N
---
----
--
-----
-
-
G
R
---
Y
Y
E
PA
PGRNY
G
VG
VN
fig|637388.3.peg.1475
Escherichia coli O157:H7 str. FRIK2000 (29-694/700)
MIVSA
APQVVSE
L
DT
P
A
A
VSV
V
DG
EE
M
R
L
A
-
TPRI
N
LSE
S
L
T
G
-
VPG
L
Q
V
QNR
Q
NY
A
Q-
-
-
D
LQ
L
SIRG
F
G
SRS
T
YGIRGIRLYV
DG
I
P
ATMPDG
--
QG
QT
S
N
I
D
L-
-
----
-
-
---
--
-
SS
VQNV
EVLRGP
F
SALYGN
-
A
S
GGV
M
N
VT
T
Q
T
G
Q
QPPTIEASSYYGSF
GS
W
RY
G
LK
A
TG
A
TG
D
GT
Q
P
---
G
DVDY
TV
S
TT
R
F
TTH
G
--
-
-
-
---Y
R
DH
S
GAQ
K
NL
A
N
A
-------
KLGVRIDDASK
L
S
L
IFNS
V
DIK
A
D
D
P
GG
LT
KA
E
WK
A
NPQQ
A
P
RA
E
QYD
T
R
K
-----
TIK
Q
TQ
A
G
L
R
Y
ER
SL
SSR
-----------------
D
D
M
S
V
M
M
Y
A
-------------
-
-
GERETTQ
Y
QS
I
P
M
----
APQL
N
PSHAGSVIT
L
Q
R
---
HYQ
G
I
D
-
---
-------
-
----
----
S
RWTHR
G
EL
GV
P
V
------
T
F
T
T
G
L
N
Y
ENM
S
EN
R
KGYNNFR
L
NS----
-
--
-
G
MPEYGQKGELRR
D
ER
N
L
MWN
I
DPYLQ
TQWQ
L
SE
K
L
S
L
D
AG
V
RY
SSVWFDSN
DH
------------
YVTP
GN
GDDSGDASYH
K
W
L
P
AGS
L
KYA
M
T
D
A
W
N
I
Y
L
A
AG
RG
FET
P
T
I
N
E
------
L
SYRAD
G
---
--
QS
G
M--
-
-----
-
-
N
F
G
LKP
S
T
N
D
T
I
EIG
SKTRIGD
GL
L
S
-
L
A
L
F
Q
TD
TD
DE
IV
V
-------
D
S
SSGGRTT
Y
K
N
A
GK
T
R
RQ
G
A
E
L
A
WDQ
R
-
FAG
D
FRVNA
S
W
TW
L
DATYRSN
VC
N
EQ
DC
---
N
G
N
----
R
MP
G
I
A
RN
M
G
F
A
S
I
G
Y
VPE
D
GWYAGMEA
R
YM
G
D
IM
A
D--
-
--
----
--
-----
D
EN
T
AKAPS
YTLVGL
FTG
Y
K
Y
N
Y
HNL
T
V
D
L
FGR
VDNLFDK
E
Y
VGSV
I
VNE
S
N
---
----
--
-----
-
-
G
R
---
Y
Y
E
PA
PGRNY
G
VG
VN
fig|570506.3.peg.3238
Escherichia coli O157:H7 str. FRIK966 (29-694/700)
MIVSA
APQVVSE
L
DT
P
A
A
VSV
V
DG
EE
M
R
L
A
-
TPRI
N
LSE
S
L
T
G
-
VPG
L
Q
V
QNR
Q
NY
A
Q-
-
-
D
LQ
L
SIRG
F
G
SRS
T
YGIRGIRLYV
DG
I
P
ATMPDG
--
QG
QT
S
N
I
D
L-
-
----
-
-
---
--
-
SS
VQNV
EVLRGP
F
SALYGN
-
A
S
GGV
M
N
VT
T
Q
T
G
Q
QPPTIEASSYYGSF
GS
W
RY
G
LK
A
TG
A
TG
D
GT
Q
P
---
G
DVDY
TV
S
TT
R
F
TTH
G
--
-
-
-
---Y
R
DH
S
GAQ
K
NL
A
N
A
-------
KLGVRIDDASK
L
S
L
IFNS
V
DIK
A
D
D
P
GG
LT
KA
E
WK
A
NPQQ
A
P
RA
E
QYD
T
R
K
-----
TIK
Q
TQ
A
G
L
R
Y
ER
SL
SSR
-----------------
D
D
M
S
V
M
M
Y
A
-------------
-
-
GERETTQ
Y
QS
I
P
M
----
APQL
N
PSHAGSVIT
L
Q
R
---
HYQ
G
I
D
-
---
-------
-
----
----
S
RWTHR
G
EL
GV
P
V
------
T
F
T
T
G
L
N
Y
ENM
S
EN
R
KGYNNFR
L
NS----
-
--
-
G
MPEYGQKGELRR
D
ER
N
L
MWN
I
DPYLQ
TQWQ
L
SE
K
L
S
L
D
AG
V
RY
SSVWFDSN
DH
------------
YVTP
GN
GDDSGDASYH
K
W
L
P
AGS
L
KYA
M
T
D
A
W
N
I
Y
L
A
AG
RG
FET
P
T
I
N
E
------
L
SYRAD
G
---
--
QS
G
M--
-
-----
-
-
N
F
G
LKP
S
T
N
D
T
I
EIG
SKTRIGD
GL
L
S
-
L
A
L
F
Q
TD
TD
DE
IV
V
-------
D
S
SSGGRTT
Y
K
N
A
GK
T
R
RQ
G
A
E
L
A
WDQ
R
-
FAG
D
FRVNA
S
W
TW
L
DATYRSN
VC
N
EQ
DC
---
N
G
N
----
R
MP
G
I
A
RN
M
G
F
A
S
I
G
Y
VPE
D
GWYAGMEA
R
YM
G
D
IM
A
D--
-
--
----
--
-----
D
EN
T
AKAPS
YTLVGL
FTG
Y
K
Y
N
Y
HNL
T
V
D
L
FGR
VDNLFDK
E
Y
VGSV
I
VNE
S
N
---
----
--
-----
-
-
G
R
---
Y
Y
E
PA
PGRNY
G
VG
VN
fig|386585.9.peg.2156
Escherichia coli O157:H7 str. Sakai (29-694/700)
MIVSA
APQVVSE
L
DT
P
A
A
VSV
V
DG
EE
M
R
L
A
-
TPRI
N
LSE
S
L
T
G
-
VPG
L
Q
V
QNR
Q
NY
A
Q-
-
-
D
LQ
L
SIRG
F
G
SRS
T
YGIRGIRLYV
DG
I
P
ATMPDG
--
QG
QT
S
N
I
D
L-
-
----
-
-
---
--
-
SS
VQNV
EVLRGP
F
SALYGN
-
A
S
GGV
M
N
VT
T
Q
T
G
Q
QPPTIEASSYYGSF
GS
W
RY
G
LK
A
TG
A
TG
D
GT
Q
P
---
G
DVDY
TV
S
TT
R
F
TTH
G
--
-
-
-
---Y
R
DH
S
GAQ
K
NL
A
N
A
-------
KLGVRIDDASK
L
S
L
IFNS
V
DIK
A
D
D
P
GG
LT
KA
E
WK
A
NPQQ
A
P
RA
E
QYD
T
R
K
-----
TIK
Q
TQ
A
G
L
R
Y
ER
SL
SSR
-----------------
D
D
M
S
V
M
M
Y
A
-------------
-
-
GERETTQ
Y
QS
I
P
M
----
APQL
N
PSHAGSVIT
L
Q
R
---
HYQ
G
I
D
-
---
-------
-
----
----
S
RWTHR
G
EL
GV
P
V
------
T
F
T
T
G
L
N
Y
ENM
S
EN
R
KGYNNFR
L
NS----
-
--
-
G
MPEYGQKGELRR
D
ER
N
L
MWN
I
DPYLQ
TQWQ
L
SE
K
L
S
L
D
AG
V
RY
SSVWFDSN
DH
------------
YVTP
GN
GDDSGDASYH
K
W
L
P
AGS
L
KYA
M
T
D
A
W
N
I
Y
L
A
AG
RG
FET
P
T
I
N
E
------
L
SYRAD
G
---
--
QS
G
M--
-
-----
-
-
N
F
G
LKP
S
T
N
D
T
I
EIG
SKTRIGD
GL
L
S
-
L
A
L
F
Q
TD
TD
DE
IV
V
-------
D
S
SSGGRTT
Y
K
N
A
GK
T
R
RQ
G
A
E
L
A
WDQ
R
-
FAG
D
FRVNA
S
W
TW
L
DATYRSN
VC
N
EQ
DC
---
N
G
N
----
R
MP
G
I
A
RN
M
G
F
A
S
I
G
Y
VPE
D
GWYAGMEA
R
YM
G
D
IM
A
D--
-
--
----
--
-----
D
EN
T
AKAPS
YTLVGL
FTG
Y
K
Y
N
Y
HNL
T
V
D
L
FGR
VDNLFDK
E
Y
VGSV
I
VNE
S
N
---
----
--
-----
-
-
G
R
---
Y
Y
E
PA
PGRNY
G
VG
VN
fig|544404.4.peg.1966
Escherichia coli O157:H7 str. TW14359 (29-694/700)
MIVSA
APQVVSE
L
DT
P
A
A
VSV
V
DG
EE
M
R
L
A
-
TPRI
N
LSE
S
L
T
G
-
VPG
L
Q
V
QNR
Q
NY
A
Q-
-
-
D
LQ
L
SIRG
F
G
SRS
T
YGIRGIRLYV
DG
I
P
ATMPDG
--
QG
QT
S
N
I
D
L-
-
----
-
-
---
--
-
SS
VQNV
EVLRGP
F
SALYGN
-
A
S
GGV
M
N
VT
T
Q
T
G
Q
QPPTIEASSYYGSF
GS
W
RY
G
LK
A
TG
A
TG
D
GT
Q
P
---
G
DVDY
TV
S
TT
R
F
TTH
G
--
-
-
-
---Y
R
DH
S
GAQ
K
NL
A
N
A
-------
KLGVRIDDASK
L
S
L
IFNS
V
DIK
A
D
D
P
GG
LT
KA
E
WK
A
NPQQ
A
P
RA
E
QYD
T
R
K
-----
TIK
Q
TQ
A
G
L
R
Y
ER
SL
SSR
-----------------
D
D
M
S
V
M
M
Y
A
-------------
-
-
GERETTQ
Y
QS
I
P
M
----
APQL
N
PSHAGSVIT
L
Q
R
---
HYQ
G
I
D
-
---
-------
-
----
----
S
RWTHR
G
EL
GV
P
V
------
T
F
T
T
G
L
N
Y
ENM
S
EN
R
KGYNNFR
L
NS----
-
--
-
G
MPEYGQKGELRR
D
ER
N
L
MWN
I
DPYLQ
TQWQ
L
SE
K
L
S
L
D
AG
V
RY
SSVWFDSN
DH
------------
YVTP
GN
GDDSGDASYH
K
W
L
P
AGS
L
KYA
M
T
D
A
W
N
I
Y
L
A
AG
RG
FET
P
T
I
N
E
------
L
SYRAD
G
---
--
QS
G
M--
-
-----
-
-
N
F
G
LKP
S
T
N
D
T
I
EIG
SKTRIGD
GL
L
S
-
L
A
L
F
Q
TD
TD
DE
IV
V
-------
D
S
SSGGRTT
Y
K
N
A
GK
T
R
RQ
G
A
E
L
A
WDQ
R
-
FAG
D
FRVNA
S
W
TW
L
DATYRSN
VC
N
EQ
DC
---
N
G
N
----
R
MP
G
I
A
RN
M
G
F
A
S
I
G
Y
VPE
D
GWYAGMEA
R
YM
G
D
IM
A
D--
-
--
----
--
-----
D
EN
T
AKAPS
YTLVGL
FTG
Y
K
Y
N
Y
HNL
T
V
D
L
FGR
VDNLFDK
E
Y
VGSV
I
VNE
S
N
---
----
--
-----
-
-
G
R
---
Y
Y
E
PA
PGRNY
G
VG
VN
fig|502346.5.peg.5316
Escherichia coli O157:H7 str. TW14588 (29-694/700)
MIVSA
APQVVSE
L
DT
P
A
A
VSV
V
DG
EE
M
R
L
A
-
TPRI
N
LSE
S
L
T
G
-
VPG
L
Q
V
QNR
Q
NY
A
Q-
-
-
D
LQ
L
SIRG
F
G
SRS
T
YGIRGIRLYV
DG
I
P
ATMPDG
--
QG
QT
S
N
I
D
L-
-
----
-
-
---
--
-
SS
VQNV
EVLRGP
F
SALYGN
-
A
S
GGV
M
N
VT
T
Q
T
G
Q
QPPTIEASSYYGSF
GS
W
RY
G
LK
A
TG
A
TG
D
GT
Q
P
---
G
DVDY
TV
S
TT
R
F
TTH
G
--
-
-
-
---Y
R
DH
S
GAQ
K
NL
A
N
A
-------
KLGVRIDDASK
L
S
L
IFNS
V
DIK
A
D
D
P
GG
LT
KA
E
WK
A
NPQQ
A
P
RA
E
QYD
T
R
K
-----
TIK
Q
TQ
A
G
L
R
Y
ER
SL
SSR
-----------------
D
D
M
S
V
M
M
Y
A
-------------
-
-
GERETTQ
Y
QS
I
P
M
----
APQL
N
PSHAGSVIT
L
Q
R
---
HYQ
G
I
D
-
---
-------
-
----
----
S
RWTHR
G
EL
GV
P
V
------
T
F
T
T
G
L
N
Y
ENM
S
EN
R
KGYNNFR
L
NS----
-
--
-
G
MPEYGQKGELRR
D
ER
N
L
MWN
I
DPYLQ
TQWQ
L
SE
K
L
S
L
D
AG
V
RY
SSVWFDSN
DH
------------
YVTP
GN
GDDSGDASYH
K
W
L
P
AGS
L
KYA
M
T
D
A
W
N
I
Y
L
A
AG
RG
FET
P
T
I
N
E
------
L
SYRAD
G
---
--
QS
G
M--
-
-----
-
-
N
F
G
LKP
S
T
N
D
T
I
EIG
SKTRIGD
GL
L
S
-
L
A
L
F
Q
TD
TD
DE
IV
V
-------
D
S
SSGGRTT
Y
K
N
A
GK
T
R
RQ
G
A
E
L
A
WDQ
R
-
FAG
D
FRVNA
S
W
TW
L
DATYRSN
VC
N
EQ
DC
---
N
G
N
----
R
MP
G
I
A
RN
M
G
F
A
S
I
G
Y
VPE
D
GWYAGMEA
R
YM
G
D
IM
A
D--
-
--
----
--
-----
D
EN
T
AKAPS
YTLVGL
FTG
Y
K
Y
N
Y
HNL
T
V
D
L
FGR
VDNLFDK
E
Y
VGSV
I
VNE
S
N
---
----
--
-----
-
-
G
R
---
Y
Y
E
PA
PGRNY
G
VG
VN
fig|701177.3.peg.1800
Escherichia coli O55:H7 str. CB9615 (29-694/700)
MIVSA
APQVVSE
L
DT
P
A
A
VSV
V
DG
EE
M
R
L
A
-
TPRI
N
LSE
S
L
T
G
-
VPG
L
Q
V
QNR
Q
NY
A
Q-
-
-
D
LQ
L
SIRG
F
G
SRS
T
YGIRGIRLYV
DG
I
P
ATMPDG
--
QG
QT
S
N
I
D
L-
-
----
-
-
---
--
-
SS
VQNV
EVLRGP
F
SALYGN
-
A
S
GGV
M
N
VT
T
Q
T
G
Q
QPPTIEASSYYGSF
GS
W
RY
G
LK
A
TG
A
TG
D
GT
Q
P
---
G
DVDY
TV
S
TT
R
F
TTH
G
--
-
-
-
---Y
R
DH
S
GAQ
K
NL
A
N
A
-------
KLGVRIDDASK
L
S
L
IFNS
V
DIK
A
D
D
P
GG
LT
KA
E
WK
A
NPQQ
A
P
RA
E
QYD
T
R
K
-----
TIK
Q
TQ
A
G
L
R
Y
ER
SL
SSR
-----------------
D
D
M
S
V
M
M
Y
A
-------------
-
-
GERETTQ
Y
QS
I
P
M
----
APQL
N
PSHAGSVIT
L
Q
R
---
HYQ
G
I
D
-
---
-------
-
----
----
S
RWTHR
G
EL
GV
P
V
------
T
F
T
T
G
L
N
Y
ENM
S
EN
R
KGYNNFR
L
NS----
-
--
-
G
MPEYGQKGELRR
D
ER
N
L
MWN
I
DPYLQ
TQWQ
L
SE
K
L
S
L
D
AG
V
RY
SSVWFDSN
DH
------------
YVTP
GN
GDDSGDASYH
K
W
L
P
AGS
L
KYA
M
T
D
A
W
N
I
Y
L
A
AG
RG
FET
P
T
I
N
E
------
L
SYRAD
G
---
--
QS
G
M--
-
-----
-
-
N
F
G
LKP
S
T
N
D
T
I
EIG
SKTRIGD
GL
L
S
-
L
A
L
F
Q
TD
TD
DE
IV
V
-------
D
S
SSGGRTT
Y
K
N
A
GK
T
R
RQ
G
A
E
L
A
WDQ
R
-
FAG
D
FRVNA
S
W
TW
L
DATYRSN
VC
N
EQ
DC
---
N
G
N
----
R
MP
G
I
A
RN
M
G
F
A
S
I
G
Y
VPE
D
GWYAGMEA
R
YM
G
D
IM
A
D--
-
--
----
--
-----
D
EN
T
AKAPS
YTLVGL
FTG
Y
K
Y
N
Y
HNL
T
V
D
L
FGR
VDNLFDK
E
Y
VGSV
I
VNE
S
N
---
----
--
-----
-
-
G
R
---
Y
Y
E
PA
PGRNY
G
VG
VN
fig|431946.3.peg.1428
Escherichia coli SE15 (29-694/700)
MIVSA
APQVVSE
L
DT
P
A
A
VSV
V
DG
EE
M
R
L
A
-
TPRI
N
LSE
S
L
T
G
-
VPG
L
Q
V
QNR
Q
NY
A
Q-
-
-
D
LQ
L
SIRG
F
G
SRS
T
YGIRGIRLYV
DG
I
P
ATMPDG
--
QG
QT
S
N
I
D
L-
-
----
-
-
---
--
-
SS
VQNV
EVLRGP
F
SALYGN
-
A
S
G
D
V
M
N
VT
T
Q
T
G
Q
QPPTIEASSYYGSF
GS
W
RY
G
LK
A
TG
A
TG
D
GT
Q
P
---
G
DVDY
TV
A
TT
R
F
TTH
G
--
-
-
-
---Y
R
DH
S
GAQ
K
NL
A
N
A
-------
KLGVRIDDASK
L
S
L
IFNS
V
DIK
A
D
D
P
GG
LT
E
A
E
WK
A
NPQQ
A
P
RA
E
QYD
M
R
K
-----
TIK
Q
TQ
A
G
L
R
Y
ER
SL
SAQ
-----------------
D
D
M
S
V
M
M
Y
A
-------------
-
-
GERETTQ
Y
QS
I
P
M
----
APQL
N
PSHAGGVIT
L
Q
R
---
HYQ
G
I
D
-
---
-------
-
----
----
S
RWTHR
G
EL
GV
P
V
------
T
F
T
T
G
L
N
Y
ENM
S
EN
R
KGYNNFR
L
NR----
-
--
-
G
VPEYGQKGELRR
D
ER
N
L
MWN
V
DPYLQ
TQWQ
LTD
K
L
S
L
D
AG
V
RY
SSVWFDSN
DH
------------
YVTP
GN
GDDSGDASYH
K
W
L
P
AGS
L
KYA
M
T
D
A
W
N
V
Y
L
A
AG
RG
FET
P
T
I
N
E
------
L
SYRAD
G
---
--
QS
G
M--
-
-----
-
-
N
F
G
LKP
S
T
N
D
T
I
EIG
SKTRIGD
GL
L
S
-
L
A
L
F
Q
TD
TD
DE
IV
V
-------
D
S
SSGGRTT
Y
K
N
A
GK
T
R
RQ
G
A
E
L
A
WDQ
R
-
FAG
D
FRVKA
S
W
TW
L
DATYRSN
VC
N
EQ
DC
---
N
G
N
----
R
MP
G
I
A
RN
M
G
F
A
S
I
G
Y
IPE
D
GWYAGTEA
R
YM
G
D
IM
A
D--
-
--
----
--
-----
D
EN
T
AKAPS
YTLVGL
FTG
Y
K
Y
N
Y
HNL
T
V
D
L
FGR
VDNLFDK
E
Y
VGSV
I
VNE
S
N
---
----
--
-----
-
-
G
R
---
Y
Y
E
PA
PGRNY
G
VG
I
N
fig|573235.3.peg.2085
Escherichia coli O26:H11 str. 11368 (29-694/700)
MIVSA
APQVVSE
L
DT
P
A
A
VSV
V
DG
EE
M
R
L
A
-
TPRI
N
LSE
S
L
T
G
-
VPG
L
Q
V
QNR
Q
NY
A
Q-
-
-
D
LQ
L
SIRG
F
G
SRS
T
YGIRGIRLYV
DG
I
P
ATMPDG
--
QG
QT
S
N
I
D
L-
-
----
-
-
---
--
-
SS
VQNV
EVLRGP
F
SALYGN
-
A
S
GGV
M
N
VT
T
Q
T
G
Q
QPPTIEASSYYGSF
GS
W
RY
G
LK
A
TG
A
TG
D
GT
Q
P
---
G
DVDY
TV
S
TT
R
F
TTH
G
--
-
-
-
---Y
R
DH
S
GAQ
K
NL
A
N
A
-------
KLGVRIDEASK
L
S
L
IFNS
V
DIK
A
D
D
P
GG
LT
KA
E
WK
A
NPQQ
A
P
RA
E
QYD
T
R
K
-----
TIK
Q
TQ
A
G
L
R
Y
ER
SL
SAQ
-----------------
D
D
M
S
V
M
M
Y
A
-------------
-
-
GERETTQ
Y
QS
I
P
M
----
APQL
N
PSHAGGVIT
L
Q
R
---
HYQ
G
I
D
-
---
-------
-
----
----
S
RWTHR
G
EL
GV
P
V
------
T
F
T
T
G
L
N
Y
ENM
S
EN
R
KGYNNFR
Q
NS----
-
--
-
G
MPEYGQKGELRR
D
ER
N
L
MWN
I
DPYLQ
TQWQ
L
SE
K
L
S
L
D
AG
V
RY
SSVWFDSN
DH
------------
YVTP
GN
GDDSGDASYH
K
W
L
P
AGS
L
KYA
M
T
D
A
W
N
I
Y
L
A
AG
RG
FET
P
T
I
N
E
------
L
SYRAD
G
---
--
QS
G
M--
-
-----
-
-
N
F
G
LKP
S
T
N
D
T
I
EIG
SKTRIGD
GL
L
S
-
L
A
L
F
Q
TD
TD
DE
IV
V
-------
D
S
SSGGRTT
Y
K
N
A
GK
T
R
RQ
G
A
E
L
A
WDQ
R
-
FAG
D
FRVNA
S
W
TW
L
DATYRSN
VC
N
EQ
DC
---
N
G
N
----
R
MP
G
I
A
RN
M
G
F
A
S
I
G
Y
VPE
D
GWYAGTEA
R
YM
G
D
IM
A
D--
-
--
----
--
-----
D
EN
T
AKAPS
YTLVGL
FTG
Y
K
Y
N
Y
HNL
T
V
D
L
FGR
VDNLFDK
E
Y
VGSV
I
VNE
S
N
---
----
--
-----
-
-
G
R
---
Y
Y
E
PS
PGRNY
G
VG
M
N
fig|749538.3.peg.1556
Escherichia coli MS 116-1 (1-666/672)
MIVSA
APQVVSE
L
DT
P
A
A
VSV
V
DG
EE
M
R
L
A
-
TPRI
N
LSE
S
L
T
G
-
VPG
L
Q
V
QNR
Q
NY
A
Q-
-
-
D
LQ
L
SIRG
F
G
SRS
T
YGIRGIRLYV
DG
I
P
ATMPDG
--
QG
QT
S
N
I
D
L-
-
----
-
-
---
--
-
SS
VQNV
K
VLRGP
F
SALYGN
-
A
S
GGV
M
N
VT
T
Q
T
G
Q
QPPTIEASSYYGSF
GS
W
RY
G
LK
A
TG
A
TG
D
GT
Q
P
---
G
DVDY
TV
S
TT
R
F
TTH
G
--
-
-
-
---Y
R
DH
S
GAQ
K
NL
A
N
A
-------
KLGVRIDEASK
L
S
L
IFNS
V
DIK
A
D
D
P
GG
LT
KA
E
WK
A
NPQQ
A
P
RA
E
QYD
T
R
K
-----
TIK
Q
TQ
A
G
L
R
Y
ER
SL
SSR
-----------------
D
D
M
S
V
M
M
Y
A
-------------
-
-
GERETTQ
Y
QS
I
P
M
----
APQL
N
PSHAGGVIT
L
Q
R
---
HYQ
G
I
D
-
---
-------
-
----
----
S
RWTHR
G
EL
GV
P
V
------
T
F
T
T
G
L
N
Y
ENM
S
EN
R
KGYNNFR
L
NS----
-
--
-
G
MPEYGQKGELRR
D
ER
N
L
MWN
I
DPYLQ
TQWQ
L
SE
K
L
S
L
D
AG
V
RY
SSVWFDSN
DH
------------
YVTP
GN
GDDSGDASYH
K
W
L
P
AGS
L
KYA
M
T
D
A
W
N
I
Y
L
A
AG
RG
FET
P
T
I
N
E
------
L
SYRAD
G
---
--
QS
G
M--
-
-----
-
-
N
L
G
LKP
S
T
N
D
T
I
EIG
SKTRIGD
GL
L
S
-
L
A
L
F
Q
TD
TD
DE
IV
V
-------
D
S
SSGGRTT
Y
K
N
A
GK
T
R
RQ
G
A
E
L
A
WDQ
R
-
FAG
D
FRVNA
S
W
TW
L
DATYRSN
VC
N
EQ
DC
---
N
G
N
----
R
MP
G
I
A
RN
M
G
F
A
S
I
G
Y
VPE
D
GWYAGTEA
R
YM
G
D
IM
A
D--
-
--
----
--
-----
D
EN
T
AKAPS
YTLVGL
FTG
Y
K
Y
N
Y
HNL
T
V
D
L
FGR
VDNLFDK
E
Y
VGSV
I
VNE
S
N
---
----
--
-----
-
-
G
R
---
Y
Y
E
PS
PGRNY
G
VG
M
N
fig|585396.4.peg.1916
Escherichia coli O111:H- str. 11128 (29-694/700)
MIVS
T
APQVVSE
L
DT
P
A
A
VSV
V
DG
EE
M
R
L
A
-
TPRI
N
LSE
S
L
T
G
-
VPG
L
Q
V
QNR
Q
NY
A
Q-
-
-
D
LQ
L
SIRG
F
G
SRS
T
YGIRGIRLYV
DG
I
P
ATMPDG
--
QG
QT
S
N
I
D
L-
-
----
-
-
---
--
-
SS
VQNV
EVLRGP
F
SALYGN
-
A
S
GGV
M
N
VT
T
Q
T
G
Q
QPPTIEASSYYGSF
GS
W
RY
G
LK
A
TG
A
TG
D
GT
Q
P
---
G
DVDY
TV
S
TT
R
F
TTH
G
--
-
-
-
---Y
R
DH
S
GAQ
K
NL
A
N
A
-------
KLGVRIDEASK
L
S
L
IFNS
V
DIK
A
D
D
P
GG
LT
KA
E
WK
A
NPQQ
A
P
RA
E
QYD
T
R
K
-----
TIK
Q
TQ
A
G
L
R
Y
ER
SL
SAQ
-----------------
D
D
M
S
V
M
M
Y
A
-------------
-
-
GERETTQ
Y
QS
I
P
M
----
APQL
N
PSHAGGVIT
L
Q
R
---
HYQ
G
I
D
-
---
-------
-
----
----
S
RWTHR
G
EL
GV
P
V
------
T
F
T
T
G
L
N
Y
ENM
S
EN
R
KGYNNFR
L
NS----
-
--
-
G
MPEYGQKGELRR
D
ER
N
L
MWN
I
DPYLQ
TQWQ
L
SE
K
L
S
L
D
AG
V
RY
SSVWFDSN
DH
------------
YVTP
GN
GDDSGDASYH
K
W
L
P
AGS
L
KYA
M
T
D
A
W
N
I
Y
L
A
AG
RG
FET
P
T
I
N
E
------
L
SYRAD
G
---
--
QS
G
M--
-
-----
-
-
N
F
G
LKP
S
T
N
D
T
I
EIG
SKTRIGD
GL
L
S
-
L
A
L
F
Q
TD
TD
DE
IV
V
-------
D
S
SSGGRTT
Y
K
N
A
GK
T
R
RQ
G
A
E
L
A
WDQ
R
-
FAG
D
FRVNA
S
W
TW
L
DATYRSN
VC
N
EQ
DC
---
N
G
N
----
R
MP
G
I
A
RN
M
G
F
A
S
I
G
Y
VPE
D
GWYAGTEA
R
YM
G
D
IM
A
D--
-
--
----
--
-----
D
EN
T
AKAPS
YTLVGL
FTG
Y
K
Y
N
Y
HNL
T
V
D
L
FGR
VDNLFDK
E
Y
VGSV
I
VNE
S
N
---
----
--
-----
-
-
G
R
---
Y
Y
E
PS
PGRNY
G
VG
M
N
fig|6666666.5357.peg.3442
Escherichia coli TY-2482 (59-750/759)
I
IVSA
SRSNRTV
A
EM
A
Q
T
TW
VI
EN
A
E
L
E
Q
QI
QGGK
E
L
K
D
A
L
A
Q
L
I
PG
L
D
V
SSQ
S
RT
-
--
-
-
N
YG
MNM
RG
--
---
--
--
R
PLV
V
LIDG
V
R
LN----
--
--
-S
S
R
S
D
SR
QLDSV
D
P
---
--
-
FN
I
D
H
IEV
I
S
G
-
A
T
ALYG
G
G
S
T
GG
LI
NI
V
TKKG
Q
----------
PETM
ME
F
EA
G
TK
S
GF
N
SS
K
DH
D
E
RIA
G
----
AV
S
GG
N
D
HIS
G
R
L
-
-
-
SVAY
Q
KF
G
GWF
D
GN
G
D
A
-------
----TLLDNTQ
T
G
L
QHSN
R
L--
-
-
D
I
M
G
TG
--
-
--
-
----
-
-
TL
N
IDE
SRQ
LQ
L
IT
QYY
K
SQ
G
D
D
N
Y
GL
N
L
GKG
FSAISGSSTPYVSKGLN
S
D
R
I
P
G
T
E
R
HLISLQYSDSDFL
G
Q
ELVGQVY
Y
RD
E
S
LRYYPF
P
TV
N
ANKQATAFS
S
S
Q
QDT
DQY
G
M
K
-
---
-------
-
----
----
-
-----
--
L
TL
NS
QLMDGW
Q
I
T
W
G
L
D
A
EHE
R
FT
S
-NQMFFD
L
AQASAS
G
GL
N
N
HKIYTTGRYPSY
D
IT
N
L
---
-
AA
F
LQ
SSYD
I
N
D
I
F
T
V
S
G
G
V
RY
QYTENRVD
D
FIDYTQQQKIAAG
KAIS
A
D
AIPG
G
SVD
Y
D
N
FL
F
NAG
L
LMH
I
T
E
R
Q
Q
AW
F
N
FS
Q
G
VAL
P
D
P
G
K
------
-
-YYGR
G
IYG
AA
VN
G
HLS
L
TKSVN
V
S
D
S
K
L
E
GV
K
V
D
S
Y
E
L
G
WRF-TGD
N
L
R
T
Q
I
A
A
Y
Y
S
L
SN
KS
V
E
R
-------
-
-
-NKDLTI
S
V
K
D
D
R
R
R
IY
G
V
E
G
A
VDY
LI
PDT
D
WSTGV
N
F
NV
L
-------
-K
T
E
S
KV
---
N
G
Q
WQNYD
V
K
E
SSPSK
A
T
A
Y
I
N
W
AP-
E
PWSLRVQS
T
TS
F
D
VS
-
---
-
--
----
--
-----
D
AE
G
NDING
YT
T
V
D
F
ISS
W
Q
L
P
-
---
V
G
T
L
SFS
V
E
NLFD
R
D
Y
TTV-
-
---
-
-
---
WGQR
A
P
LYYSP
G
Y
G
P
ASL
Y
D
Y
KG
R
GR
T
fig|1040638.4.peg.1199
Escherichia coli O104:H4 str. LB226692 (32-723/732)
I
IVSA
SRSNRTV
A
EM
A
Q
T
TW
VI
EN
A
E
L
E
Q
QI
QGGK
E
L
K
D
A
L
A
Q
L
I
PG
L
D
V
SSQ
S
RT
-
--
-
-
N
YG
MNM
RG
--
---
--
--
R
PLV
V
LIDG
V
R
LN----
--
--
-S
S
R
S
D
SR
QLDSV
D
P
---
--
-
FN
I
D
H
IEV
I
S
G
-
A
T
ALYG
G
G
S
T
GG
LI
NI
V
TKKG
Q
----------
PETM
ME
F
EA
G
TK
S
GF
N
SS
K
DH
D
E
RIA
G
----
AV
S
GG
N
D
HIS
G
R
L
-
-
-
SVAY
Q
KF
G
GWF
D
GN
G
D
A
-------
----TLLDNTQ
T
G
L
QHSN
R
L--
-
-
D
I
M
G
TG
--
-
--
-
----
-
-
TL
N
IDE
SRQ
LQ
L
IT
QYY
K
SQ
G
D
D
N
Y
GL
N
L
GKG
FSAISGSSTPYVSKGLN
S
D
R
I
P
G
T
E
R
HLISLQYSDSDFL
G
Q
ELVGQVY
Y
RD
E
S
LRYYPF
P
TV
N
ANKQATAFS
S
S
Q
QDT
DQY
G
M
K
-
---
-------
-
----
----
-
-----
--
L
TL
NS
QLMDGW
Q
I
T
W
G
L
D
A
EHE
R
FT
S
-NQMFFD
L
AQASAS
G
GL
N
N
HKIYTTGRYPSY
D
IT
N
L
---
-
AA
F
LQ
SSYD
I
N
D
I
F
T
V
S
G
G
V
RY
QYTENRVD
D
FIDYTQQQKIAAG
KAIS
A
D
AIPG
G
SVD
Y
D
N
FL
F
NAG
L
LMH
I
T
E
R
Q
Q
AW
F
N
FS
Q
G
VAL
P
D
P
G
K
------
-
-YYGR
G
IYG
AA
VN
G
HLS
L
TKSVN
V
S
D
S
K
L
E
GV
K
V
D
S
Y
E
L
G
WRF-TGD
N
L
R
T
Q
I
A
A
Y
Y
S
L
SN
KS
V
E
R
-------
-
-
-NKDLTI
S
V
K
D
D
R
R
R
IY
G
V
E
G
A
VDY
LI
PDT
D
WSTGV
N
F
NV
L
-------
-K
T
E
S
KV
---
N
G
Q
WQKYD
V
K
E
SSPSK
A
T
A
Y
I
N
W
AP-
E
PWSLRVQS
T
TS
F
D
VS
-
---
-
--
----
--
-----
D
AE
G
NDING
YT
T
V
D
F
ISS
W
Q
L
P
-
---
V
G
T
L
SFS
V
E
NLFD
R
D
Y
TTV-
-
---
-
-
---
WGQR
A
P
LYYSP
G
Y
G
P
ASL
Y
D
Y
KG
R
GR
T
fig|585055.6.peg.4664
Escherichia coli 55989 (32-723/732)
I
IVSA
SRSNRTV
A
EM
A
Q
T
TW
VI
EN
A
E
L
E
Q
QI
QGGK
E
L
K
D
A
L
A
Q
L
I
PG
L
D
V
SSQ
S
RT
-
--
-
-
N
YG
MNM
RG
--
---
--
--
R
PLV
V
LIDG
V
R
LN----
--
--
-S
S
R
S
D
SR
QLDSV
D
P
---
--
-
FN
I
D
H
IEV
I
S
G
-
A
T
ALYG
G
G
S
T
GG
LI
NI
V
TKKG
Q
----------
PETM
ME
F
EA
G
TK
S
GF
N
SS
K
DH
D
E
RIA
G
----
AV
S
GG
N
D
HIS
G
R
L
-
-
-
SVAY
Q
KF
G
GWF
D
GN
G
D
A
-------
----TLLDNTQ
T
G
L
QHSN
R
L--
-
-
D
I
M
G
TG
--
-
--
-
----
-
-
TL
N
IDE
SRQ
LQ
L
IT
QYY
K
SQ
G
D
D
N
Y
GL
N
L
GKG
FSAISGSSTPYVSKGLN
S
D
R
I
P
G
T
E
R
HLISLQYSDSDFL
G
Q
ELVGQVY
Y
RD
E
S
LRYYPF
P
TV
N
ANKQATAFS
S
S
Q
QDT
DQY
G
M
K
-
---
-------
-
----
----
-
-----
--
L
TL
NS
QLMDGW
Q
I
T
W
G
L
D
A
EHE
R
FT
S
-NQMFFD
L
AQASAS
G
GL
N
N
HKIYTTGRYPSY
D
IT
N
L
---
-
AA
F
LQ
SSYD
I
N
D
I
F
T
V
S
G
G
V
RY
QYTENRVD
D
FIDYTQQQKIAAG
KAIS
A
D
AIPG
G
SVD
Y
D
N
FL
F
NAG
L
LMH
I
T
E
R
Q
Q
AW
F
N
FS
Q
G
VAL
P
D
P
G
K
------
-
-YYGR
G
IYG
AA
VN
G
HLS
L
TKSVN
V
S
D
S
K
L
E
GV
K
V
D
S
Y
E
L
G
WRF-TGD
N
L
R
T
Q
I
A
A
Y
Y
S
L
SN
KS
V
E
R
-------
-
-
-NKDLTI
S
V
K
D
D
R
R
R
IY
G
V
E
G
A
VDY
LI
PDT
D
WSTGV
N
F
NV
L
-------
-K
T
E
S
KV
---
N
G
Q
WQKYD
V
K
E
SSPSK
A
T
A
Y
I
N
W
AP-
E
PWSLRVQS
T
TS
F
D
VS
-
---
-
--
----
--
-----
D
AE
G
NDING
YT
T
V
D
F
ISS
W
Q
L
P
-
---
V
G
T
L
SFS
V
E
NLFD
R
D
Y
TTV-
-
---
-
-
---
WGQR
A
P
LYYSP
G
Y
G
P
ASL
Y
D
Y
KG
R
GR
T
fig|585055.8.peg.4669
Escherichia coli 55989 (32-723/732)
I
IVSA
SRSNRTV
A
EM
A
Q
T
TW
VI
EN
A
E
L
E
Q
QI
QGGK
E
L
K
D
A
L
A
Q
L
I
PG
L
D
V
SSQ
S
RT
-
--
-
-
N
YG
MNM
RG
--
---
--
--
R
PLV
V
LIDG
V
R
LN----
--
--
-S
S
R
S
D
SR
QLDSV
D
P
---
--
-
FN
I
D
H
IEV
I
S
G
-
A
T
ALYG
G
G
S
T
GG
LI
NI
V
TKKG
Q
----------
PETM
ME
F
EA
G
TK
S
GF
N
SS
K
DH
D
E
RIA
G
----
AV
S
GG
N
D
HIS
G
R
L
-
-
-
SVAY
Q
KF
G
GWF
D
GN
G
D
A
-------
----TLLDNTQ
T
G
L
QHSN
R
L--
-
-
D
I
M
G
TG
--
-
--
-
----
-
-
TL
N
IDE
SRQ
LQ
L
IT
QYY
K
SQ
G
D
D
N
Y
GL
N
L
GKG
FSAISGSSTPYVSKGLN
S
D
R
I
P
G
T
E
R
HLISLQYSDSDFL
G
Q
ELVGQVY
Y
RD
E
S
LRYYPF
P
TV
N
ANKQATAFS
S
S
Q
QDT
DQY
G
M
K
-
---
-------
-
----
----
-
-----
--
L
TL
NS
QLMDGW
Q
I
T
W
G
L
D
A
EHE
R
FT
S
-NQMFFD
L
AQASAS
G
GL
N
N
HKIYTTGRYPSY
D
IT
N
L
---
-
AA
F
LQ
SSYD
I
N
D
I
F
T
V
S
G
G
V
RY
QYTENRVD
D
FIDYTQQQKIAAG
KAIS
A
D
AIPG
G
SVD
Y
D
N
FL
F
NAG
L
LMH
I
T
E
R
Q
Q
AW
F
N
FS
Q
G
VAL
P
D
P
G
K
------
-
-YYGR
G
IYG
AA
VN
G
HLS
L
TKSVN
V
S
D
S
K
L
E
GV
K
V
D
S
Y
E
L
G
WRF-TGD
N
L
R
T
Q
I
A
A
Y
Y
S
L
SN
KS
V
E
R
-------
-
-
-NKDLTI
S
V
K
D
D
R
R
R
IY
G
V
E
G
A
VDY
LI
PDT
D
WSTGV
N
F
NV
L
-------
-K
T
E
S
KV
---
N
G
Q
WQKYD
V
K
E
SSPSK
A
T
A
Y
I
N
W
AP-
E
PWSLRVQS
T
TS
F
D
VS
-
---
-
--
----
--
-----
D
AE
G
NDING
YT
T
V
D
F
ISS
W
Q
L
P
-
---
V
G
T
L
SFS
V
E
NLFD
R
D
Y
TTV-
-
---
-
-
---
WGQR
A
P
LYYSP
G
Y
G
P
ASL
Y
D
Y
KG
R
GR
T
fig|585397.7.peg.4881
Escherichia coli ED1a (32-723/732)
I
IVSA
SRSNRTV
A
EM
A
Q
T
TW
VI
EN
A
E
L
E
Q
QI
QGGK
E
L
K
D
A
L
A
Q
L
I
PG
L
D
V
SSQ
S
RT
-
--
-
-
N
YG
MNM
RG
--
---
--
--
R
PLV
V
LIDG
V
R
LN----
--
--
-S
S
R
S
D
SR
QLDSV
D
P
---
--
-
FN
I
D
H
IEV
I
S
G
-
A
T
ALYG
G
G
S
T
GG
LI
NI
V
TKKG
Q
----------
PETM
ME
F
EA
G
TK
S
GF
N
SS
K
DH
D
E
RIA
G
----
AV
S
GG
N
D
HIS
G
R
L
-
-
-
SVAY
Q
KF
G
GWF
D
GN
G
D
A
-------
----TLLDNTQ
T
G
L
QHSN
R
L--
-
-
D
I
M
G
TG
--
-
--
-
----
-
-
TL
N
IDE
SRQ
LQ
L
IT
QYY
K
SQ
G
D
D
N
Y
GL
N
L
GKG
FSAISGSSTPYVSKGLN
S
D
R
I
P
G
T
E
R
HLISLQYSDSDFL
G
Q
ELVGQVY
Y
RD
E
S
LRYYPF
P
TV
N
ANKQATAFS
S
S
Q
QDT
DQY
G
M
K
-
---
-------
-
----
----
-
-----
--
L
TL
NS
QLMDGW
Q
I
T
W
G
L
D
A
EHE
R
FT
S
-NQMFFD
L
AQASAS
G
GL
N
N
HKIYTTGRYPSY
D
IT
N
L
---
-
AA
F
LQ
SSYD
I
N
D
I
F
T
V
S
G
G
V
RY
QYTENRVD
D
FIDYTQQQKIAAG
KAIS
A
D
AIPG
G
SVD
Y
D
N
FL
F
NAG
L
LMH
I
T
E
R
Q
Q
AW
F
N
FS
Q
G
VAL
P
D
P
G
K
------
-
-YYGR
G
IYG
AA
VN
G
HLS
L
TKSVN
V
S
D
S
K
L
E
GV
K
V
D
S
Y
E
L
G
WRF-TGD
N
L
R
T
Q
I
A
A
Y
Y
S
L
SN
KS
V
E
R
-------
-
-
-NKDLTI
S
V
K
D
D
R
R
R
IY
G
V
E
G
A
VDY
LI
PDT
D
WSTGV
N
F
NV
L
-------
-K
T
E
S
KV
---
N
G
Q
WQKYD
V
K
E
SSPSK
A
T
A
Y
I
N
W
AP-
E
PWSLRVQS
T
TS
F
D
VS
-
---
-
--
----
--
-----
D
AE
G
NDING
YT
T
V
D
F
ISS
W
Q
L
P
-
---
V
G
T
L
SFS
V
E
NLFD
R
D
Y
TTV-
-
---
-
-
---
WGQR
A
P
LYYSP
G
Y
G
P
ASL
Y
D
Y
KG
R
GR
T
fig|585397.9.peg.4881
Escherichia coli ED1a (32-723/732)
I
IVSA
SRSNRTV
A
EM
A
Q
T
TW
VI
EN
A
E
L
E
Q
QI
QGGK
E
L
K
D
A
L
A
Q
L
I
PG
L
D
V
SSQ
S
RT
-
--
-
-
N
YG
MNM
RG
--
---
--
--
R
PLV
V
LIDG
V
R
LN----
--
--
-S
S
R
S
D
SR
QLDSV
D
P
---
--
-
FN
I
D
H
IEV
I
S
G
-
A
T
ALYG
G
G
S
T
GG
LI
NI
V
TKKG
Q
----------
PETM
ME
F
EA
G
TK
S
GF
N
SS
K
DH
D
E
RIA
G
----
AV
S
GG
N
D
HIS
G
R
L
-
-
-
SVAY
Q
KF
G
GWF
D
GN
G
D
A
-------
----TLLDNTQ
T
G
L
QHSN
R
L--
-
-
D
I
M
G
TG
--
-
--
-
----
-
-
TL
N
IDE
SRQ
LQ
L
IT
QYY
K
SQ
G
D
D
N
Y
GL
N
L
GKG
FSAISGSSTPYVSKGLN
S
D
R
I
P
G
T
E
R
HLISLQYSDSDFL
G
Q
ELVGQVY
Y
RD
E
S
LRYYPF
P
TV
N
ANKQATAFS
S
S
Q
QDT
DQY
G
M
K
-
---
-------
-
----
----
-
-----
--
L
TL
NS
QLMDGW
Q
I
T
W
G
L
D
A
EHE
R
FT
S
-NQMFFD
L
AQASAS
G
GL
N
N
HKIYTTGRYPSY
D
IT
N
L
---
-
AA
F
LQ
SSYD
I
N
D
I
F
T
V
S
G
G
V
RY
QYTENRVD
D
FIDYTQQQKIAAG
KAIS
A
D
AIPG
G
SVD
Y
D
N
FL
F
NAG
L
LMH
I
T
E
R
Q
Q
AW
F
N
FS
Q
G
VAL
P
D
P
G
K
------
-
-YYGR
G
IYG
AA
VN
G
HLS
L
TKSVN
V
S
D
S
K
L
E
GV
K
V
D
S
Y
E
L
G
WRF-TGD
N
L
R
T
Q
I
A
A
Y
Y
S
L
SN
KS
V
E
R
-------
-
-
-NKDLTI
S
V
K
D
D
R
R
R
IY
G
V
E
G
A
VDY
LI
PDT
D
WSTGV
N
F
NV
L
-------
-K
T
E
S
KV
---
N
G
Q
WQKYD
V
K
E
SSPSK
A
T
A
Y
I
N
W
AP-
E
PWSLRVQS
T
TS
F
D
VS
-
---
-
--
----
--
-----
D
AE
G
NDING
YT
T
V
D
F
ISS
W
Q
L
P
-
---
V
G
T
L
SFS
V
E
NLFD
R
D
Y
TTV-
-
---
-
-
---
WGQR
A
P
LYYSP
G
Y
G
P
ASL
Y
D
Y
KG
R
GR
T
fig|749531.3.peg.1027
Escherichia coli MS 69-1 (32-723/732)
I
IVSA
SRSNRTV
A
EM
A
Q
T
TW
VI
EN
A
E
L
E
Q
QI
QGGK
E
L
K
D
A
L
A
Q
L
I
PG
L
D
V
SSQ
S
RT
-
--
-
-
N
YG
MNM
RG
--
---
--
--
R
PLV
V
LIDG
V
R
LN----
--
--
-S
S
R
S
D
SR
QLDSV
D
P
---
--
-
FN
I
D
H
IEV
I
S
G
-
A
T
ALYG
G
G
S
T
GG
LI
NI
V
TKKG
Q
----------
PETM
ME
F
EA
G
TK
S
GF
N
SS
K
DH
D
E
RIA
G
----
AV
S
GG
N
D
HIS
G
R
L
-
-
-
SVAY
Q
KF
G
GWF
D
GN
G
D
A
-------
----TLLDNTQ
T
G
L
QHSN
R
L--
-
-
D
I
M
G
TG
--
-
--
-
----
-
-
TL
N
IDE
SRQ
LQ
L
IT
QYY
K
SQ
G
D
D
N
Y
GL
N
L
GKG
FSAISGSSTPYVSKGLN
S
D
R
I
P
G
T
E
R
HLISLQYSDSDFL
G
Q
ELVGQVY
Y
RD
E
S
LRYYPF
P
TV
N
ANKQATAFS
S
S
Q
QDT
DQY
G
M
K
-
---
-------
-
----
----
-
-----
--
L
TL
NS
QLMDGW
Q
I
T
W
G
L
D
A
EHE
R
FT
S
-NQMFFD
L
AQASAS
G
GL
N
N
HKIYTTGRYPSY
D
IT
N
L
---
-
AA
F
LQ
SSYD
I
N
D
I
F
T
V
S
G
G
V
RY
QYTENRVD
D
FIDYTQQQKIAAG
KAIS
A
D
AIPG
G
SVD
Y
D
N
FL
F
NAG
L
LMH
I
T
E
R
Q
Q
AW
F
N
FS
Q
G
VAL
P
D
P
G
K
------
-
-YYGR
G
IYG
AA
VN
G
HLP
L
TKSVN
V
S
D
S
K
L
E
GV
K
V
D
S
Y
E
L
G
WRF-TGD
N
L
R
T
Q
I
A
A
Y
Y
S
L
SN
KS
V
E
R
-------
-
-
-NKDLTI
S
V
K
D
D
R
R
R
IY
G
V
E
G
A
VDY
LI
PDT
D
WSTGV
N
F
NV
L
-------
-K
T
E
S
KV
---
N
G
Q
WQKYD
V
K
E
SSPSK
A
T
A
Y
I
N
W
AP-
E
PWSLRVQS
T
TS
F
D
VS
-
---
-
--
----
--
-----
D
AE
G
NDING
YT
T
V
D
F
ISS
W
Q
L
P
-
---
V
G
T
L
SFS
V
E
NLFD
R
D
Y
TTV-
-
---
-
-
---
WGQR
A
P
LYYSP
G
Y
G
P
ASL
Y
D
Y
KG
R
GR
T
fig|656440.3.peg.3057
Escherichia coli TA206 (32-723/732)
I
IVSA
SRSNRTV
A
EM
A
Q
T
TW
VI
EN
A
E
L
E
Q
QI
QGGK
E
L
K
D
A
L
A
Q
L
I
PG
L
D
V
SSQ
S
RT
-
--
-
-
N
YG
MNM
RG
--
---
--
--
R
PLV
V
LIDG
V
R
LN----
--
--
-S
S
R
S
D
SR
QLDSV
D
P
---
--
-
FN
I
D
H
IEV
I
S
G
-
A
T
ALYG
G
G
S
T
GG
LI
NI
V
TKKG
Q
----------
PETM
ME
F
EA
G
TK
S
GF
N
SS
K
DH
D
E
RIA
G
----
AV
S
GG
N
D
HIS
G
R
L
-
-
-
SVAY
Q
KF
G
GWF
D
GN
G
D
A
-------
----TLLDNTQ
T
G
L
QHSN
R
L--
-
-
D
I
M
G
TG
--
-
--
-
----
-
-
TL
N
IDE
SRQ
LQ
L
IT
QYY
K
SQ
G
D
D
N
Y
GL
N
L
GKG
FSAISGSSTPYVSKGLN
S
D
R
I
P
G
T
E
R
HLISLQYSDSDFL
G
Q
ELVGQVY
Y
RD
E
S
LRFYPF
P
TV
N
ANKQATAFS
S
S
Q
QDT
DQY
G
M
K
-
---
-------
-
----
----
-
-----
--
L
TL
NS
QLMDGW
Q
I
T
W
G
L
D
A
EHE
R
FT
S
-NQMFFD
L
AQASAS
G
GM
N
N
HKIYTTGRYPSY
D
IT
N
L
---
-
AA
F
LQ
SSYD
I
N
D
I
F
T
V
S
G
G
V
RY
QYTENRVD
D
FIGYTQQQKIAAG
KAIS
A
D
AIPG
G
SVD
Y
D
N
FL
F
NAG
L
LMH
I
T
E
R
Q
Q
AW
F
N
FS
Q
G
VAL
P
D
P
G
K
------
-
-YYGR
G
IYG
AA
VN
G
HLP
L
TKSVN
V
S
D
S
K
L
E
GV
K
V
D
S
Y
E
L
G
WRF-TGD
N
L
R
T
Q
I
A
A
Y
Y
S
L
SN
KS
V
E
R
-------
-
-
-NKDLTI
S
V
K
D
D
R
R
R
IY
G
V
E
G
A
VDY
LI
PDT
D
WSTGA
N
F
NV
L
-------
-K
T
E
S
KV
---
N
G
Q
WQKYN
V
K
E
SSPSK
A
T
A
Y
I
S
W
AP-
D
PWSLRVQS
T
TS
F
D
VS
-
---
-
--
----
--
-----
D
AE
G
NDING
YT
T
V
D
F
ISS
W
Q
L
P
-
---
V
G
T
L
SFS
V
E
NLFD
R
D
Y
TTV-
-
---
-
-
---
WGQR
A
P
LYYSP
G
Y
G
P
ASL
Y
D
Y
KG
R
GR
T
fig|525281.3.peg.3270
Escherichia coli 83972 (15-705/714)
V
VSA
NRSNRTV
A
EM
A
Q
T
TW
VI
EN
A
E
L
E
Q
QI
QGGK
E
L
K
D
A
L
A
Q
L
I
PG
L
D
V
SSR
S
RT
-
--
-
-
N
YG
MNV
RG
--
---
--
--
R
PLV
V
L
V
DG
V
R
LN----
--
--
-S
S
R
T
D
SR
QLDSI
D
P
---
--
-
FN
I
D
H
IEV
I
S
G
-
A
TS
LYG
G
G
S
T
GG
LI
NI
V
TKKG
Q
----------
PETM
ME
F
EA
G
TK
S
GF
S
SS
K
DH
D
E
RIA
G
----
AV
S
GG
N
E
HIS
G
R
L
-
-
-
SVAY
Q
KF
G
GWF
D
GN
G
D
A
-------
----TLLDNTQ
T
G
L
QYSD
R
L--
-
-
D
I
M
G
TG
--
-
--
-
----
-
-
TL
N
IDE
SRQ
LQ
L
IT
QYY
K
SQ
G
D
D
D
Y
GL
N
L
GKG
FSAIRGTSTPFVSNGLN
S
D
R
I
P
G
T
E
R
HLISLQYSDSAFL
G
Q
ELVGQVY
Y
RD
E
S
LRFYPF
P
TV
N
ANKQVTAFS
S
S
Q
QDT
DQY
G
M
K
-
---
-------
-
----
----
-
-----
--
L
TL
NS
KPMDGW
Q
I
T
W
G
L
D
A
DHE
R
FT
S
-NQMFFD
L
AQASAS
G
GL
N
N
KKIYTTGRYPSY
D
IT
N
L
---
-
AA
F
LQ
SDYD
I
N
N
L
F
T
L
N
G
G
V
RY
QYTENKID
D
FIGYAQQRQIAAG
KATS
A
D
AIPG
G
SVD
Y
D
N
FL
F
NAG
L
LMH
I
T
E
R
Q
Q
AW
L
N
FS
Q
G
V
E
L
P
D
P
G
K
------
-
-YYGR
G
IYG
AA
VN
G
HLP
L
TKSVN
V
S
D
S
K
L
E
GV
K
V
D
S
Y
E
L
G
WRF-TGN
N
L
R
T
Q
I
A
A
Y
Y
S
I
SD
KS
V
V
A
-------
-
-
-NKDLTI
S
V
V
D
D
K
R
R
IY
G
V
E
G
A
VDY
LI
PDT
D
WSTGV
N
F
NV
L
-------
-K
T
E
S
KV
---
N
G
T
WQKYD
V
K
T
ASPSK
A
T
A
Y
I
G
W
AP-
D
PWSLRVQS
T
TS
F
D
VS
-
---
-
--
----
--
-----
D
AQ
G
YKVDG
YT
T
V
D
L
LGS
Y
Q
L
P
-
---
V
G
T
L
SFS
IE
NLFD
R
D
Y
TTV-
-
---
-
-
---
WGQR
A
P
LYYSP
G
Y
G
P
ASL
Y
D
Y
KG
R
GR
T
fig|655817.3.peg.3422
Escherichia coli ABU 83972 (15-705/714)
V
VSA
NRSNRTV
A
EM
A
Q
T
TW
VI
EN
A
E
L
E
Q
QI
QGGK
E
L
K
D
A
L
A
Q
L
I
PG
L
D
V
SSR
S
RT
-
--
-
-
N
YG
MNV
RG
--
---
--
--
R
PLV
V
L
V
DG
V
R
LN----
--
--
-S
S
R
T
D
SR
QLDSI
D
P
---
--
-
FN
I
D
H
IEV
I
S
G
-
A
TS
LYG
G
G
S
T
GG
LI
NI
V
TKKG
Q
----------
PETM
ME
F
EA
G
TK
S
GF
S
SS
K
DH
D
E
RIA
G
----
AV
S
GG
N
E
HIS
G
R
L
-
-
-
SVAY
Q
KF
G
GWF
D
GN
G
D
A
-------
----TLLDNTQ
T
G
L
QYSD
R
L--
-
-
D
I
M
G
TG
--
-
--
-
----
-
-
TL
N
IDE
SRQ
LQ
L
IT
QYY
K
SQ
G
D
D
D
Y
GL
N
L
GKG
FSAIRGTSTPFVSNGLN
S
D
R
I
P
G
T
E
R
HLISLQYSDSAFL
G
Q
ELVGQVY
Y
RD
E
S
LRFYPF
P
TV
N
ANKQVTAFS
S
S
Q
QDT
DQY
G
M
K
-
---
-------
-
----
----
-
-----
--
L
TL
NS
KPMDGW
Q
I
T
W
G
L
D
A
DHE
R
FT
S
-NQMFFD
L
AQASAS
G
GL
N
N
KKIYTTGRYPSY
D
IT
N
L
---
-
AA
F
LQ
SDYD
I
N
N
L
F
T
L
N
G
G
V
RY
QYTENKID
D
FIGYAQQRQIAAG
KATS
A
D
AIPG
G
SVD
Y
D
N
FL
F
NAG
L
LMH
I
T
E
R
Q
Q
AW
L
N
FS
Q
G
V
E
L
P
D
P
G
K
------
-
-YYGR
G
IYG
AA
VN
G
HLP
L
TKSVN
V
S
D
S
K
L
E
GV
K
V
D
S
Y
E
L
G
WRF-TGN
N
L
R
T
Q
I
A
A
Y
Y
S
I
SD
KS
V
V
A
-------
-
-
-NKDLTI
S
V
V
D
D
K
R
R
IY
G
V
E
G
A
VDY
LI
PDT
D
WSTGV
N
F
NV
L
-------
-K
T
E
S
KV
---
N
G
T
WQKYD
V
K
T
ASPSK
A
T
A
Y
I
G
W
AP-
D
PWSLRVQS
T
TS
F
D
VS
-
---
-
--
----
--
-----
D
AQ
G
YKVDG
YT
T
V
D
L
LGS
Y
Q
L
P
-
---
V
G
T
L
SFS
IE
NLFD
R
D
Y
TTV-
-
---
-
-
---
WGQR
A
P
LYYSP
G
Y
G
P
ASL
Y
D
Y
KG
R
GR
T
fig|749528.3.peg.4269
Escherichia coli MS 45-1 (33-723/732)
V
VSA
NRSNRTV
A
EM
A
Q
T
TW
VI
EN
A
E
L
E
Q
QI
QGGK
E
L
K
D
A
L
A
Q
L
I
PG
L
D
V
SSR
S
RT
-
--
-
-
N
YG
MNV
RG
--
---
--
--
R
PLV
V
L
V
DG
V
R
LN----
--
--
-S
S
R
T
D
SR
QLDSI
D
P
---
--
-
FN
I
D
H
IEV
I
S
G
-
A
TS
LYG
G
G
S
T
GG
LI
NI
V
TKKG
Q
----------
PETM
ME
F
EA
G
TK
S
GF
S
SS
K
DH
D
E
RIA
G
----
AV
S
GG
N
E
HIS
G
R
L
-
-
-
SVAY
Q
KF
G
GWF
D
GN
G
D
A
-------
----TLLDNTQ
T
G
L
QYSD
R
L--
-
-
D
I
M
G
TG
--
-
--
-
----
-
-
TL
N
IDE
SRQ
LQ
L
IT
QYY
K
SQ
G
D
D
D
Y
GL
N
L
GKG
FSAIRGTSTPFVSNGLN
S
D
R
I
P
G
T
E
R
HLISLQYSDSAFL
G
Q
ELVGQVY
Y
RD
E
S
LRFYPF
P
TV
N
ANKQVTAFS
S
S
Q
QDT
DQY
G
M
K
-
---
-------
-
----
----
-
-----
--
L
TL
NS
KPMDGW
Q
I
T
W
G
L
D
A
DHE
R
FT
S
-NQMFFD
L
AQASAS
G
GL
N
N
KKIYTTGRYPSY
D
IT
N
L
---
-
AA
F
LQ
SDYD
I
N
N
L
F
T
L
N
G
G
V
RY
QYTENKID
D
FIGYAQQRQIAAG
KATS
A
D
AIPG
G
SVD
Y
D
N
FL
F
NAG
L
LMH
I
T
E
R
Q
Q
AW
L
N
FS
Q
G
V
E
L
P
D
P
G
K
------
-
-YYGR
G
IYG
AA
VN
G
HLP
L
TKSVN
V
S
D
S
K
L
E
GV
K
V
D
S
Y
E
L
G
WRF-TGN
N
L
R
T
Q
I
A
A
Y
Y
S
I
SD
KS
V
V
A
-------
-
-
-NKDLTI
S
V
V
D
D
K
R
R
IY
G
V
E
G
A
VDY
LI
PDT
D
WSTGV
N
F
NV
L
-------
-K
T
E
S
KV
---
N
G
T
WQKYD
V
K
T
ASPSK
A
T
A
Y
I
G
W
AP-
D
PWSLRVQS
T
TS
F
D
VS
-
---
-
--
----
--
-----
D
AQ
G
YKVDG
YT
T
V
D
L
LGS
Y
Q
L
P
-
---
V
G
T
L
SFS
IE
NLFD
R
D
Y
TTV-
-
---
-
-
---
WGQR
A
P
LYYSP
G
Y
G
P
ASL
Y
D
Y
KG
R
GR
T
fig|679205.4.peg.5114
Escherichia coli MS 124-1 (33-723/732)
V
VSA
NRSNRTV
A
EM
A
Q
T
TW
VI
EN
A
E
L
E
Q
QI
QGGK
E
L
K
D
A
L
A
Q
L
I
PG
L
D
V
SSR
S
RT
-
--
-
-
N
YG
MNV
RG
--
---
--
--
R
PLV
V
L
V
DG
V
R
LN----
--
--
-S
S
R
T
D
SR
QLDSI
D
P
---
--
-
FN
I
D
H
IEV
I
S
G
-
A
TS
LYG
G
G
S
T
GG
LI
NI
V
TKKG
Q
----------
PETM
ME
F
EA
G
TK
S
GF
S
SS
K
DH
D
E
RIA
G
----
AV
S
GG
N
E
HIS
G
R
L
-
-
-
SVAY
Q
KF
G
GWF
D
GN
G
D
A
-------
----TLLDNTQ
T
G
L
QYSD
R
L--
-
-
D
I
M
G
TG
--
-
--
-
----
-
-
TL
N
IDE
SRQ
LQ
L
IT
QYY
K
SQ
G
D
D
D
Y
GL
N
L
GKG
FSAIRGTSTPFVSNGLN
S
D
R
I
P
G
T
E
R
HLISLQYSDSAFL
G
Q
ELVGQVY
Y
RD
E
S
LRFYPF
P
TV
N
ANKQVTAFS
S
S
Q
QDT
DQY
G
M
K
-
---
-------
-
----
----
-
-----
--
L
TL
NS
KPMDGW
Q
I
T
W
G
L
D
A
DHE
R
FT
S
-NQMFFD
L
AQASAS
G
GL
N
N
KKIYTTGRYPSY
D
IT
N
L
---
-
AV
F
LQ
SGYD
I
N
N
L
F
T
L
N
G
G
V
RY
QYTENKID
D
FIGYAQQRQIAAG
KATS
A
D
AIPG
G
SVD
Y
D
N
FL
F
NAG
L
LMH
I
T
E
R
Q
Q
AW
L
N
FS
Q
G
V
E
L
P
D
P
G
K
------
-
-YYGR
G
IYG
AA
VN
G
HLP
L
TKSVN
V
S
D
S
K
L
E
GV
K
V
D
S
Y
E
L
G
WRF-TGN
N
L
R
T
Q
I
A
A
Y
Y
S
I
SD
KS
V
V
A
-------
-
-
-NKDLTI
S
V
V
D
D
K
R
R
IY
G
V
E
G
A
VDY
LI
PDT
D
WSTGV
N
F
NV
L
-------
-K
T
E
S
KV
---
N
G
T
WQKYD
V
K
T
ASPSK
A
T
A
Y
I
G
W
AP-
D
PWSLRVQS
T
TS
F
D
VS
-
---
-
--
----
--
-----
D
AQ
G
YKVDG
YT
T
V
D
L
LGS
Y
Q
L
P
-
---
V
G
T
L
SFS
IE
NLFD
R
D
Y
TTV-
-
---
-
-
---
WGQR
A
P
LYYSP
G
Y
G
P
ASL
Y
D
Y
KG
R
GR
T
fig|749533.3.peg.3393
Escherichia coli MS 84-1 (15-705/714)
V
VSA
NRSNRTV
A
EM
A
Q
T
TW
VI
EN
A
E
L
E
Q
QI
QGGK
E
L
K
D
A
L
A
Q
L
I
PG
L
D
V
SSR
S
RT
-
--
-
-
N
YG
MNV
RG
--
---
--
--
R
PLV
V
L
V
DG
V
R
LN----
--
--
-S
S
R
T
D
SR
QLDSI
D
P
---
--
-
FN
I
D
H
IEV
I
S
G
-
A
TS
LYG
G
G
S
T
GG
LI
NI
V
TKKG
Q
----------
PETM
ME
F
EA
G
TK
S
GF
S
SS
K
DH
D
E
RIA
G
----
AV
S
GG
N
E
HIS
G
R
L
-
-
-
SVAY
Q
KF
G
GWF
D
GN
G
D
A
-------
----TLLDNTQ
T
G
L
QYSD
R
L--
-
-
D
I
M
G
TG
--
-
--
-
----
-
-
TL
N
IDE
SRQ
LQ
L
IT
QYY
K
SQ
G
D
D
D
Y
GL
N
L
GKG
FSAIRGTSTPFVSNGLN
S
D
R
I
P
G
T
E
R
HLISLQYSDSAFL
G
Q
ELVGQVY
Y
RD
E
S
LRFYPF
P
TV
N
ANKQVTAFS
S
S
Q
QDT
DQY
G
M
K
-
---
-------
-
----
----
-
-----
--
L
TL
NS
KPMDGW
Q
I
T
W
G
L
D
A
DHE
R
FT
S
-NQMFFD
L
AQASAS
G
GL
N
N
KKIYTTGRYPSY
D
IT
N
L
---
-
AV
F
LQ
SGYD
I
N
N
L
F
T
L
N
G
G
V
RY
QYTENKID
D
FIGYAQQRQIAAG
KATS
A
D
AIPG
G
SVD
Y
D
N
FL
F
NAG
L
LMH
I
T
E
R
Q
Q
AW
L
N
FS
Q
G
V
E
L
P
D
P
G
K
------
-
-YYGR
G
IYG
AA
VN
G
HLP
L
TKSVN
V
S
D
S
K
L
E
GV
K
V
D
S
Y
E
L
G
WRF-TGN
N
L
R
T
Q
I
A
A
Y
Y
S
I
SD
KS
V
V
A
-------
-
-
-NKDLTI
S
V
V
D
D
K
R
R
IY
G
V
E
G
A
VDY
LI
PDT
D
WSTGV
N
F
NV
L
-------
-K
T
E
S
KV
---
N
G
T
WQKYD
V
K
T
ASPSK
A
T
A
Y
I
G
W
AP-
D
PWSLRVQS
T
TS
F
D
VS
-
---
-
--
----
--
-----
D
AQ
G
YKVDG
YT
T
V
D
L
LGS
Y
Q
L
P
-
---
V
G
T
L
SFS
IE
NLFD
R
D
Y
TTV-
-
---
-
-
---
WGQR
A
P
LYYSP
G
Y
G
P
ASL
Y
D
Y
KG
R
GR
T
fig|685038.3.peg.4659
Escherichia coli O83:H1 str. NRG 857C (33-723/732)
V
VSA
NRSNRTV
A
EM
A
Q
T
TW
VI
EN
A
E
L
E
Q
QI
QGGK
E
L
K
D
A
L
A
Q
L
I
PG
L
D
V
SSR
S
RT
-
--
-
-
N
YG
MNV
RG
--
---
--
--
R
PLV
V
L
V
DG
V
R
LN----
--
--
-S
S
R
T
D
SR
QLDSI
D
P
---
--
-
FN
I
D
H
IEV
I
S
G
-
A
TS
LYG
G
G
S
T
GG
LI
NI
V
TKKG
Q
----------
PETM
ME
F
EA
G
TK
S
GF
S
SS
K
DH
D
E
RIA
G
----
AV
S
GG
N
E
HIS
G
R
L
-
-
-
SVAY
Q
KF
G
GWF
D
GN
G
D
A
-------
----TLLDNTQ
T
G
L
QYSD
R
L--
-
-
D
I
M
G
TG
--
-
--
-
----
-
-
TL
N
IDE
SRQ
LQ
L
IT
QYY
K
SQ
G
D
D
D
Y
GL
N
L
GKG
FSAIRGTSTPFVSNGLN
S
D
R
I
P
G
T
E
R
HLISLQYSDSAFL
G
Q
ELVGQVY
Y
RD
E
S
LRFYPF
P
TV
N
ANKQVTAFS
S
S
Q
QDT
DQY
G
M
K
-
---
-------
-
----
----
-
-----
--
L
TL
NS
KPMDGW
Q
I
T
W
G
L
D
A
DHE
R
FT
S
-NQMFFD
L
AQASAS
G
GL
N
N
KKIYTTGRYPSY
D
IT
N
L
---
-
AV
F
LQ
SGYD
I
N
N
L
F
T
L
N
G
G
V
RY
QYTENKID
D
FIGYAQQRQIAAG
KATS
A
D
AIPG
G
SVD
Y
D
N
FL
F
NAG
L
LMH
I
T
E
R
Q
Q
AW
L
N
FS
Q
G
V
E
L
P
D
P
G
K
------
-
-YYGR
G
IYG
AA
VN
G
HLP
L
TKSVN
V
S
D
S
K
L
E
GV
K
V
D
S
Y
E
L
G
WRF-TGN
N
L
R
T
Q
I
A
A
Y
Y
S
I
SD
KS
V
V
A
-------
-
-
-NKDLTI
S
V
V
D
D
K
R
R
IY
G
V
E
G
A
VDY
LI
PDT
D
WSTGV
N
F
NV
L
-------
-K
T
E
S
KV
---
N
G
T
WQKYD
V
K
T
ASPSK
A
T
A
Y
I
G
W
AP-
D
PWSLRVQS
T
TS
F
D
VS
-
---
-
--
----
--
-----
D
AQ
G
YKVDG
YT
T
V
D
L
LGS
Y
Q
L
P
-
---
V
G
T
L
SFS
IE
NLFD
R
D
Y
TTV-
-
---
-
-
---
WGQR
A
P
LYYSP
G
Y
G
P
ASL
Y
D
Y
KG
R
GR
T
fig|585057.4.peg.3547
Escherichia coli IAI39 (15-705/714)
V
VSA
NRSNRTV
A
EM
A
Q
T
TW
VI
EN
A
E
L
E
Q
QI
QGGK
E
L
K
D
A
L
A
Q
L
I
PG
L
D
V
SSR
S
RT
-
--
-
-
N
YG
MNV
RG
--
---
--
--
R
PLV
V
L
V
DG
V
R
LN----
--
--
-S
S
R
T
D
SR
QLDSI
D
P
---
--
-
FN
I
D
H
IEV
I
S
G
-
A
TS
LYG
G
G
S
T
GG
LI
NI
V
TKKG
Q
----------
PETM
ME
F
EA
G
TK
S
GF
S
SS
K
DH
D
E
RIA
G
----
AV
S
GG
N
E
HIS
G
R
L
-
-
-
SVAY
Q
KF
G
GWF
D
GN
G
D
A
-------
----TLLDNTQ
T
G
L
QYSD
R
L--
-
-
D
I
M
G
TG
--
-
--
-
----
-
-
TL
N
IDE
SRQ
LQ
L
IT
QYY
K
SQ
G
D
D
D
Y
GL
N
L
GKG
FSAIRGTSTPFVSNGLN
S
D
R
I
P
G
T
E
R
HLISLQYSDSAFL
G
Q
ELVGQVY
Y
RD
E
S
LRFYPF
P
TV
N
ANKQVTAFS
S
S
Q
QDT
DQY
G
M
K
-
---
-------
-
----
----
-
-----
--
L
TL
NS
KPMDGW
Q
I
T
W
G
L
D
A
DHE
R
FT
S
-NQMFFD
L
AQASAS
G
GL
N
N
KKIYTTGRYPSY
D
IT
N
L
---
-
AA
F
LQ
SGYD
I
N
N
L
F
T
L
N
G
G
V
RY
QYTENKID
D
FIGYAQQRQIAAG
KATS
A
D
AIPG
G
SVD
Y
D
N
FL
F
NAG
L
LMH
I
T
E
R
Q
Q
AW
L
N
FS
Q
G
V
E
L
P
D
P
G
K
------
-
-YYGR
G
IYG
AA
VN
G
HLP
L
TKSVN
V
S
D
S
K
L
E
GV
K
V
D
S
Y
E
L
G
WRF-TGN
N
L
R
T
Q
I
A
A
Y
Y
S
I
SD
KS
V
V
A
-------
-
-
-NKDLTI
S
V
V
D
D
K
R
R
IY
G
V
E
G
A
VDY
LI
PDT
D
WSTGV
N
F
NV
L
-------
-K
T
E
S
KV
---
N
G
T
WQKYD
V
K
T
ASPSK
A
T
A
Y
I
G
W
AP-
D
PWSLRVQS
T
TS
F
D
VS
-
---
-
--
----
--
-----
D
AQ
G
YKVDG
YT
T
V
D
L
LGS
Y
Q
L
P
-
---
V
G
T
L
SFS
IE
NLFD
R
D
Y
TTV-
-
---
-
-
---
WGQR
A
P
LYYSP
G
Y
G
P
ASL
Y
D
Y
KG
R
GR
T
fig|585057.6.peg.3556
Escherichia coli IAI39 (15-705/714)
V
VSA
NRSNRTV
A
EM
A
Q
T
TW
VI
EN
A
E
L
E
Q
QI
QGGK
E
L
K
D
A
L
A
Q
L
I
PG
L
D
V
SSR
S
RT
-
--
-
-
N
YG
MNV
RG
--
---
--
--
R
PLV
V
L
V
DG
V
R
LN----
--
--
-S
S
R
T
D
SR
QLDSI
D
P
---
--
-
FN
I
D
H
IEV
I
S
G
-
A
TS
LYG
G
G
S
T
GG
LI
NI
V
TKKG
Q
----------
PETM
ME
F
EA
G
TK
S
GF
S
SS
K
DH
D
E
RIA
G
----
AV
S
GG
N
E
HIS
G
R
L
-
-
-
SVAY
Q
KF
G
GWF
D
GN
G
D
A
-------
----TLLDNTQ
T
G
L
QYSD
R
L--
-
-
D
I
M
G
TG
--
-
--
-
----
-
-
TL
N
IDE
SRQ
LQ
L
IT
QYY
K
SQ
G
D
D
D
Y
GL
N
L
GKG
FSAIRGTSTPFVSNGLN
S
D
R
I
P
G
T
E
R
HLISLQYSDSAFL
G
Q
ELVGQVY
Y
RD
E
S
LRFYPF
P
TV
N
ANKQVTAFS
S
S
Q
QDT
DQY
G
M
K
-
---
-------
-
----
----
-
-----
--
L
TL
NS
KPMDGW
Q
I
T
W
G
L
D
A
DHE
R
FT
S
-NQMFFD
L
AQASAS
G
GL
N
N
KKIYTTGRYPSY
D
IT
N
L
---
-
AA
F
LQ
SGYD
I
N
N
L
F
T
L
N
G
G
V
RY
QYTENKID
D
FIGYAQQRQIAAG
KATS
A
D
AIPG
G
SVD
Y
D
N
FL
F
NAG
L
LMH
I
T
E
R
Q
Q
AW
L
N
FS
Q
G
V
E
L
P
D
P
G
K
------
-
-YYGR
G
IYG
AA
VN
G
HLP
L
TKSVN
V
S
D
S
K
L
E
GV
K
V
D
S
Y
E
L
G
WRF-TGN
N
L
R
T
Q
I
A
A
Y
Y
S
I
SD
KS
V
V
A
-------
-
-
-NKDLTI
S
V
V
D
D
K
R
R
IY
G
V
E
G
A
VDY
LI
PDT
D
WSTGV
N
F
NV
L
-------
-K
T
E
S
KV
---
N
G
T
WQKYD
V
K
T
ASPSK
A
T
A
Y
I
G
W
AP-
D
PWSLRVQS
T
TS
F
D
VS
-
---
-
--
----
--
-----
D
AQ
G
YKVDG
YT
T
V
D
L
LGS
Y
Q
L
P
-
---
V
G
T
L
SFS
IE
NLFD
R
D
Y
TTV-
-
---
-
-
---
WGQR
A
P
LYYSP
G
Y
G
P
ASL
Y
D
Y
KG
R
GR
T
fig|679206.4.peg.4873
Escherichia coli MS 119-7 (33-723/732)
V
VSA
NRSNRTV
A
EM
A
Q
T
TW
VI
EN
A
E
L
E
Q
QI
QGGK
E
L
K
D
A
L
A
Q
L
I
PG
L
D
V
SSR
S
RT
-
--
-
-
N
YG
MNV
RG
--
---
--
--
R
PLV
V
L
V
DG
V
R
LN----
--
--
-S
S
R
T
D
SR
QLDSI
D
P
---
--
-
FN
I
D
H
IEV
I
S
G
-
A
TS
LYG
G
G
S
T
GG
LI
NI
V
TKKG
Q
----------
PETM
ME
F
EA
G
TK
S
GF
S
SS
K
DH
D
E
RIA
G
----
AV
S
GG
N
E
HIS
G
R
L
-
-
-
SVAY
Q
KF
G
GWF
D
GN
G
D
A
-------
----TLLDNTQ
T
G
L
QYSD
R
L--
-
-
D
I
M
G
TG
--
-
--
-
----
-
-
TL
N
IDE
SRQ
LQ
L
IT
QYY
K
SQ
G
D
D
D
Y
GL
N
L
GKG
FSAIRGTSTPFVSNGLN
S
D
R
I
P
G
T
E
R
HLISLQYSDSAFL
G
Q
ELVGQVY
Y
RD
E
S
LRFYPF
P
TV
N
ANKQVTAFS
S
S
Q
QDT
DQY
G
M
K
-
---
-------
-
----
----
-
-----
--
L
TL
NS
KPMDGW
Q
I
T
W
G
L
D
A
DHE
R
FT
S
-NQMFFD
L
AQASAS
G
GL
N
N
KKIYTTGRYPSY
D
IT
N
L
---
-
AA
F
LQ
SGYD
I
N
N
L
F
T
L
N
G
G
V
RY
QYTENKID
D
FIGYAQQRQIAAG
KATS
A
D
AIPG
G
SVD
Y
D
N
FL
F
NAG
L
LMH
I
T
E
R
Q
Q
AW
L
N
FS
Q
G
V
E
L
P
D
P
G
K
------
-
-YYGR
G
IYG
AA
VN
G
HLP
L
TKSVN
V
S
D
S
K
L
E
GV
K
V
D
S
Y
E
L
G
WRF-TGN
N
L
R
T
Q
I
A
A
Y
Y
S
I
SD
KS
V
V
A
-------
-
-
-NKDLTI
S
V
V
D
D
K
R
R
IY
G
V
E
G
A
VDY
LI
PDT
D
WSTGV
N
F
NV
L
-------
-K
T
E
S
KV
---
N
G
T
WQKYD
V
K
T
ASPSK
A
T
A
Y
I
G
W
AP-
D
PWSLRVQS
T
TS
F
D
VS
-
---
-
--
----
--
-----
D
AQ
G
YKVDG
YT
T
V
D
L
LGS
Y
Q
L
P
-
---
V
G
T
L
SFS
IE
NLFD
R
D
Y
TTV-
-
---
-
-
---
WGQR
A
P
LYYSP
G
Y
G
P
ASL
Y
D
Y
KG
R
GR
T
fig|749548.3.peg.1829
Escherichia coli MS 196-1 (15-705/714)
V
VSA
NRSNRTV
A
EM
A
Q
T
TW
VI
EN
A
E
L
E
Q
QI
QGGK
E
L
K
D
A
L
A
Q
L
I
PG
L
D
V
SSR
S
RT
-
--
-
-
N
YG
MNV
RG
--
---
--
--
R
PLV
V
L
V
DG
V
R
LN----
--
--
-S
S
R
T
D
SR
QLDSI
D
P
---
--
-
FN
I
D
H
IEV
I
S
G
-
A
TS
LYG
G
G
S
T
GG
LI
NI
V
TKKG
Q
----------
PETM
ME
F
EA
G
TK
S
GF
S
SS
K
DH
D
E
RIA
G
----
AV
S
GG
N
E
HIS
G
R
L
-
-
-
SVAY
Q
KF
G
GWF
D
GN
G
D
A
-------
----TLLDNTQ
T
G
L
QYSD
R
L--
-
-
D
I
M
G
TG
--
-
--
-
----
-
-
TL
N
IDE
SRQ
LQ
L
IT
QYY
K
SQ
G
D
D
D
Y
GL
N
L
GKG
FSAIRGTSTPFVSNGLN
S
D
R
I
P
G
T
E
R
HLISLQYSDSAFL
G
Q
ELVGQVY
Y
RD
E
S
LRFYPF
P
TV
N
ANKQVTAFS
S
S
Q
QDT
DQY
G
M
K
-
---
-------
-
----
----
-
-----
--
L
TL
NS
KPMDGW
Q
I
T
W
G
L
D
A
DHE
R
FT
S
-NQMFFD
L
AQASAS
G
GL
N
N
KKIYTTGRYPSY
D
IT
N
L
---
-
AA
F
LQ
SGYD
I
N
N
L
F
T
L
N
G
G
V
RY
QYTENKID
D
FIGYAQQRQIAAG
KATS
A
D
AIPG
G
SVD
Y
D
N
FL
F
NAG
L
LMH
I
T
E
R
Q
Q
AW
L
N
FS
Q
G
V
E
L
P
D
P
G
K
------
-
-YYGR
G
IYG
AA
VN
G
HLP
L
TKSVN
V
S
D
S
K
L
E
GV
K
V
D
S
Y
E
L
G
WRF-TGN
N
L
R
T
Q
I
A
A
Y
Y
S
I
SD
KS
V
V
A
-------
-
-
-NKDLTI
S
V
V
D
D
K
R
R
IY
G
V
E
G
A
VDY
LI
PDT
D
WSTGV
N
F
NV
L
-------
-K
T
E
S
KV
---
N
G
T
WQKYD
V
K
T
ASPSK
A
T
A
Y
I
G
W
AP-
D
PWSLRVQS
T
TS
F
D
VS
-
---
-
--
----
--
-----
D
AQ
G
YKVDG
YT
T
V
D
L
LGS
Y
Q
L
P
-
---
V
G
T
L
SFS
IE
NLFD
R
D
Y
TTV-
-
---
-
-
---
WGQR
A
P
LYYSP
G
Y
G
P
ASL
Y
D
Y
KG
R
GR
T
fig|656393.3.peg.5368
Escherichia coli H299 (15-705/714)
V
VSA
NRSNRTV
A
EM
A
Q
T
TW
VI
EN
A
E
L
E
Q
QI
QGGK
E
L
K
D
A
L
A
Q
L
I
PG
L
D
V
SSR
S
RT
-
--
-
-
N
YG
MNV
RG
--
---
--
--
R
PLV
V
L
V
DG
V
R
LN----
--
--
-S
S
R
T
D
SR
QLDSI
D
P
---
--
-
FN
I
D
H
IEV
I
S
G
-
A
TS
LYG
G
G
S
T
GG
LI
NI
V
TKKG
Q
----------
PETM
ME
F
EA
G
TK
S
GF
S
SS
K
DH
D
E
RIA
G
----
AV
S
GG
N
E
HIS
G
R
L
-
-
-
SVAY
Q
KF
G
GWF
D
GN
G
D
A
-------
----TLLDNTQ
T
G
L
QYSD
R
L--
-
-
D
I
M
G
TG
--
-
--
-
----
-
-
TL
N
IDE
SRQ
LQ
L
IT
QYY
T
SQ
G
D
D
D
Y
GL
N
L
GKG
FSAIRGTSTPFVSNGLN
S
D
R
I
P
G
T
E
R
HLISLQYSDSAFL
G
Q
ELVGQVY
Y
RD
E
S
LRFYPF
P
TV
N
ANKQVTAFS
S
S
Q
QDT
DQY
G
M
K
-
---
-------
-
----
----
-
-----
--
L
TL
NS
KPMDGW
Q
I
T
W
G
L
D
A
DHE
R
FT
S
-NQMFFD
L
AQASAS
G
GL
N
N
KKIYTTGRYPSY
D
IT
N
L
---
-
AA
F
LQ
SGYD
I
N
N
L
F
T
L
N
G
G
V
RY
QYTENKID
D
FIGYAQQRQIAAG
KATS
A
D
AIPG
G
SVD
Y
D
N
FL
F
NAG
L
LMH
I
T
E
R
Q
Q
AW
L
N
FS
Q
G
V
E
L
P
D
P
G
K
------
-
-YYGR
G
IYG
AA
VN
G
HLP
L
TKSVN
V
S
D
S
K
L
E
GV
K
V
D
S
Y
E
L
G
WRF-TGN
N
L
R
T
Q
I
A
A
Y
Y
S
I
SD
KS
V
V
A
-------
-
-
-NKDLTI
S
V
V
D
D
K
R
R
IY
G
V
E
G
A
VDY
LI
PDT
D
WSTGV
N
F
NV
L
-------
-K
T
E
S
KV
---
N
G
T
WQKYD
V
K
T
ASPSK
A
T
A
Y
I
G
W
AP-
D
PWSLRVQS
T
TS
F
D
VS
-
---
-
--
----
--
-----
D
AQ
G
YKVDG
YT
T
V
D
L
LGS
Y
Q
L
P
-
---
V
G
T
L
SFS
IE
NLFD
R
D
Y
TTV-
-
---
-
-
---
WGQR
A
P
LYYSP
G
Y
G
P
ASL
Y
D
Y
KG
R
GR
T
Consen1
Primary consensus
MIvsa
l
aa
VSvi
eEir
n
-
dlse
lr
-
vpGv
v
s
g
g
-
lqisIRGmg
Tl
------
iliDG
p
vrqg
se
d
g
----
t
pp
-
ieriEVlRGP
salYGn
A
GGVvNiiTkkg
--------------
W
s
a
n
e
e
---
G
----
s
nF
Gpl
-
d
r
g
k
a
a
-------
t
l
e
n
d
gg
--
Wk
npqq
l
e
sRq
-----
q
n
d
y
Sl
-----------------
D
t
r
yr
g
-
y
t
---------
N
l
R
---
Gl
g
-------
----
s
sel
Pi
t
T
G
ew
s
d
l
g
--
G
d
sl
---
--
fae
ltd
l
l
aG
Ry
--------
dh
------------
Gn
----------
wsP
l
l
D
w
lk
g
rgykaP
l
q
------
L
G
--
G
l
-----
gN
dLkpe
s
n
EiG
gl
a
vt
F
tD
nkIv
-------
s
y
N
gKar
G
E
a
p
-
d
n
Tw
-------
sEq
---
G
----
rls
ipeym
na
l
w
e
t
Gk
p
-
ny
av
-----
d
t
ytlVgl
wk
t
---
v
L
VdNLfdK
y
l
g
---
ag
g
g
---
y
y
PgRny
msvN
F
Consen2
Secondary consensus
lvv
t
pp
tv
d
nvad
it
me
l
l
q
a
-
n
reld
fp
ygirgirlyv
-
--
ys
g
t
-
fsam
-
--
l
vqnv
i
atr
s
m
vt
tn
qpptieassyygsf
g
l
a
d
dvdy
k
r
--
v
-
q
s
q
g
-
wdinq
l
i
v
a
n
na
ka
d
eld
p
d
t
kgnlya
r
l
q
-
s
m
ea
-
v
w
i
m
apql
-
i
-
gkfneka
qdfv
d
glv
l
n
r
r
-
-
ai
nvmwn
dpylq
p
t
v
p
fssvwfdsney
ggddsgdasyh
fl
i
f
y
a
tafet
etnpnyi
di
-
-
g
das
n
a
dw
s
a
n
de
e
gyvavgq
a
w
p
tv
s
rl
t
s
y
datyrsn
n
n
gdn
pmp
ta
t
fs
i
y
d
r
d
a
q
--
--
qkkvyg
g
ws
da
yd
n
hnl
l
ln
-
i
s
aqt
--
-
s
t
e
e
tw
vg
Consensus 1
(when a gap)
Conservative difference
Consensus 2
(when a gap)
Nonconservative diff.
Other character