┌─ Escherichia coli (1-310/332) ED1a (2)  
                                                              ┌┴─ Escherichia coli (1-310/332) 83972 (9)  
                                                             ┌┴─ Escherichia coli (1-310/332) APEC O1 (5)  
                                                            ┌┴─ Escherichia coli (1-310/332) MS 145-7   
                                                           ┌┴─ Escherichia coli (1-310/332) K12 (29)  
                                                          ┌┴┬─ Escherichia coli (1-310/332) B7A (1)  
                                                          │ └┬─ Escherichia coli (1-310/332) 536 (4)  
                                                         ┌┤  └─ Escherichia coli (1-310/332) M718   
                                       ┌─────────────────┤└─ Escherichia coli (1-310/332) MS 124-1 (1)  
                                       │                 └─ Escherichia coli (1-310/332) MS 196-1   
                                ┌──────┤           ┌─ Escherichia coli (3-326/331) 101-1 (7)  
                                │      └───────────┤ ┌─ Escherichia coli (3-326/331) M718   
                                │                  │┌┴─ Escherichia coli (3-326/331) 042 (53)  
                                │                  └┤┌─ Escherichia coli (6-316/321) str. K-12 substr. DH10B   
                                │                   └┤┌─ Escherichia coli (3-326/331) APEC O1 (6)  
              ┌─────────────────┤                    └┤ ┌─ Escherichia coli (3-326/331) MS 185-1   
              │                 │                     └┬┴─ Escherichia coli (3-326/331) MS 21-1   
              │                 │                      └┬─ fig|1040638.4.peg.2021 O104:H4 (3-326/331) str. LB226692 (13)  
              │                 │                       └┬─ Escherichia coli (3-326/331) 1044A (41)  
              │                 │                        └─ Escherichia coli (6-316/321) O157:H7 EDL933 (1)  
              │                 └─────────────┬──────────────── Escherichia coli (12-333/339) H299 (1)  
           ┌──┤                               └──────────────────┬─ Escherichia coli (12-331/343) TA271   
           │  │                                                  └┬─ fig|1040638.4.peg.666 O104:H4 (12-331/343) str. LB226692 (6)  
           │  │                                                   └┬─ Escherichia coli (12-331/343) 83972 (7)  
           │  │                                                    └─ Escherichia coli (12-331/343) ETEC H10407 (3)  
           │  │                                ┌──────────── Escherichia coli (3-318/331) M718   
           │  └────────────────────────────────┤          ┌─ Escherichia coli (3-325/331) 536 (4)  
           │                                   └──────────┤ ┌─ Escherichia coli (3-301/317) O127:H6 str. E2348/69   
           │                                              │┌┴─ Escherichia coli (34-346/362) E2348/69 (2)  
           │                                              └┤ ┌─ fig|1040638.4.peg.2778 O104:H4 (3-325/331) str. LB226692 (19)  
           │                                               └┬┴─ Escherichia coli (3-325/331) SE11   
           │                                                └┬─ Escherichia coli (24-346/352) B354   
           │                                                 └┬─ Escherichia coli (3-325/331) FVEC1412 (3)  
           │                                                  └┬─ Escherichia coli (3-317/331) 1125A (27)  
          ┌┤                                                   └─ Escherichia coli (3-325/331) E24377A (15)  
          ││                                        ┌─ Escherichia coli (12-326/350) 1044A (20)  
          ││                                       ┌┴─ Escherichia coli (4-313/337) O157:H7 (4)  
          ││                                      ┌┴─ Escherichia coli (12-326/350) 101-1 (5)  
          ││                                     ┌┴┬─ Escherichia coli (12-326/350) O111:H- str. 11128 (1)  
          ││                                    ┌┤ └─ Escherichia coli (12-326/350) B185   
          ││                                    │└┬─ Escherichia coli (12-326/350) HS  [2] 
          ││                                    │ └┬─ Escherichia coli (12-326/350) NC101   
          ││                                   ┌┤  └┬─ Escherichia coli (4-313/337) F11   
          ││                                   ││   └─ Escherichia coli (12-326/350) 536 (10)  
          ││                                  ┌┤└─ fig|1040638.4.peg.2577 O104:H4 (12-326/350) str. LB226692 (6)  
          ││            ┌─────────────────────┤└─ Escherichia coli (12-326/350) MS 69-1   
          │└────────────┤                     └─ Escherichia coli (12-326/350) MS 21-1   
          │             │                     ┌─ Escherichia coli (2-314/346) O111:H- str. 11128   
          │             └─────────────────────┤ ┌─ Escherichia coli (2-314/346) 101-1   
       ┌──┤                                   │┌┴─ Escherichia coli (2-316/348) 042 (1)  
       │  │                                   └┤┌─ fig|1040638.4.peg.3225 O104:H4 (2-314/346) str. LB226692 (3)  
       │  │                                    ││  ┌─ Escherichia coli (2-314/346) IAI39 (1)  
       │  │                                    └┤ ┌┴─ Escherichia coli (2-314/346) B7A (6)  
       │  │                                     │┌┴┬─ Escherichia coli (2-314/346) 53638 (1)  
       │  │                                     └┤ └─ Escherichia coli (2-313/346) M718   
       │  │                                      └┬─ Escherichia coli (2-314/346) K12 (12)  
       │  │                                       └┬─ Escherichia coli (2-314/346) 042 (38)  
       │  │                                        └┬─ Escherichia coli (2-314/346) 1044A (25)  
       │  │                                         └─ Escherichia coli (2-314/346) B185   
       │  │                                                        ┌─ Escherichia coli (1-320/336) SMS-3-5   
       │  │           ┌────────────────────────────────────────────┴─ Escherichia coli (1-320/336) E24377A (1)  
       │  │     ┌─────┴─────────────────────────────────── Escherichia coli (6-338/342) M605 (1)  
       │  │ ┌───┴───────────────────── Escherichia coli (8-323/344) 83972 (13)  
       │  │ │                                      ┌─ Escherichia coli (7-324/356) MS 116-1   
       │  └─┤                        ┌─────────────┴─ Escherichia coli (7-324/356) H736   
       │    │                    ┌───┴──────────────────── Escherichia coli (1-309/358) TA206   
       │    │                    │                ┌─ Escherichia coli (7-326/363) K12 (31)  
       │    └────────────────────┤               ┌┴─ Escherichia coli (4-323/360) E24377A (1)  
       │                         │              ┌┴─ Escherichia coli (7-326/363) HS (1)  
       │                         │              │  ┌─ Escherichia coli (4-323/360) MS 21-1   
       │                         └──────────────┤ ┌┴─ Escherichia coli (4-323/360) SMS-3-5   
       │                                        │┌┴─ Escherichia coli (4-323/360) FVEC1302 (3)  
       │                                        ││ ┌─ Escherichia coli (4-323/360) TA143   
     ┌─┤                                        └┤┌┴─ Escherichia coli (7-326/363) 042 (1)  
     │ │                                         ││   ┌─ fig|1040638.4.peg.5358 O104:H4 (4-323/360) str. LB226692 (5)  
     │ │                                         └┤  ┌┴─ Escherichia coli (4-323/360) MS 115-1   
     │ │                                          │ ┌┴─ Escherichia coli (4-323/360) B088 (6)  
     │ │                                          │┌┴─ Escherichia coli (4-323/360) 2362-75 (27)  
     │ │                                          └┤┌─ Escherichia coli (4-323/360) O83:H1 str. NRG 857C   
     │ │                                           └┤  ┌─ Escherichia coli (4-323/360) 536 (9)  
     │ │                                            │ ┌┴─ Escherichia coli (4-323/360) M605   
     │ │                                            └┬┴─ Escherichia coli (4-323/360) H299   
     │ │                                             └┬── Escherichia coli (4-323/360) CFT073   
     │ │                                              └┬─ Escherichia coli (4-323/360) TA206   
     │ │                                               └─ Escherichia coli (4-323/360) 83972 (7)  
     │ │                            ┌─ Escherichia coli (1-307/330) H736 (1)  
     │ │                           ┌┴─ Escherichia coli (11-318/341) ED1a (1)  
     │ │                          ┌┴┬─ fig|1040638.4.peg.1350 O104:H4 (1-307/330) str. LB226692 (3)  
     │ │                         ┌┤ └─ Escherichia coli (11-318/341) 55989 (2)  
     │ │                        ┌┤└─ Escherichia coli (1-307/330) 101-1 (48)  
     │ │                       ┌┤└─ Escherichia coli (11-318/341) K12 (64)  
     │ │                       │└┬─ Escherichia coli (11-318/341) 2362-75 (2)  
     │ │                       │ └┬─ Escherichia coli (11-318/341) M605   
     │ │  ┌────────────────────┤  └┬─ Escherichia coli (1-307/330) SE15   
┌────┤ │  │                    │   └─ Escherichia coli (11-318/341) MS 69-1   
│    │ │  │                    └─ Escherichia coli (11-318/341) MS 115-1   
│    │ │  │                          ┌─ Escherichia coli (3-319/341) K12 (75)  
│    │ └──┤                         ┌┴─ Escherichia coli (1-302/324) B088   
│    │    │                        ┌┴┬─ Escherichia coli (3-319/341) ABU 83972 (3)  
│    │    │         ┌──────────────┤ └─ Escherichia coli (3-319/341) 2362-75 (13)  
│    │    │         │              └─ Escherichia coli (3-319/341) E24377A (1)  
│    │    └─────────┤             ┌─ Escherichia coli (1-313/327) 2362-75   
│    │              │             │  ┌─ Escherichia coli (1-313/327) H591 (2)  
│    │              └─────────────┤ ┌┴─ Escherichia coli (1-313/327) E24377A (6)  
│    │                            │┌┴─ Escherichia coli (3-316/330) E24377A   
│    │                            └┤ ┌─ Escherichia coli (3-316/330) ATCC 8739  [2] 
│    │                             │┌┴─ Escherichia coli (1-313/327) B str. REL606 (2)  
│    │                             └┤ ┌─ Escherichia coli (3-316/330) APEC O1  [2] 
│    │                              └┬┴─ fig|1040638.4.peg.1465 O104:H4 (1-313/327) str. LB226692 (78)  
│    │                               └┬─ Escherichia coli (1-313/327) M605 (1)  
│    │                                └┬─ Escherichia coli (3-316/330) K12 (12)  
│    │                                 └┬─ Escherichia coli (1-313/327) 1212A (1)  
│    │                                  └─ Escherichia coli (1-313/327) B354   
│    │                               ┌─ Escherichia coli (4-330/332) O55:H7 str. CB9615   
│    └───────────────────────────────┤┌─ Escherichia coli (4-330/332) 1044A (24)  
│                                    └┤┌─ fig|1040638.4.peg.4084 O104:H4 (4-330/332) str. LB226692 (5)  
│                                     ││ ┌─ Escherichia coli (4-330/332) MS 196-1   
│                                     └┤┌┴─ Escherichia coli (4-330/332) K12 (25)  
│                                      ││  ┌─ Escherichia coli (4-330/332) O111:H- str. 11128   
│                                      └┤ ┌┴─ Escherichia coli (4-330/332) B088 (23)  
┤                                       │┌┴─ Escherichia coli (4-330/332) E110019 (1)  
│                                       └┤┌─ Escherichia coli (4-330/332) MS 69-1   
│                                        └┤┌─ Escherichia coli (4-330/332) M718   
│                                         └┤┌─ Escherichia coli (4-330/332) TA280   
│                                          └┤┌─ Escherichia coli (4-330/332) IAI39 (1)  
│                                           └┤┌─ Escherichia coli (4-330/332) H299   
│                                            └┤ ┌─ Escherichia coli (4-330/332) SMS-3-5   
│                                             │┌┴─ Escherichia coli (4-330/332) MS 21-1   
│                                             └┤ ┌─ Escherichia coli (4-330/332) WV_060327   
│                                              └┬┴─ Escherichia coli (4-330/332) APEC O1 (6)  
│                                               └┬─ Escherichia coli (4-330/332) ED1a (2)  
│                                                └┬─ Escherichia coli (4-330/332) SE15   
│                                                 └┬─ Escherichia coli (4-330/332) M605   
│                                                  └┬─ Escherichia coli (4-330/332) 2362-75 (14)  
│                                                   └─ Escherichia coli (4-330/332) NC101   
│                                              ┌─ Escherichia coli MS 145-7   
│                                             ┌┴─ Escherichia coli ED1a (1)  
│                                            ┌┴─ Escherichia coli 536 (12)  
│                                           ┌┴─ Escherichia coli K12 (8)  
│                                          ┌┴┬─ Escherichia coli 101-1 (2)  
│                                         ┌┤ └─ Escherichia coli TA280   
│                                         │└┬─ fig|1040638.4.peg.942 O104:H4 str. LB226692 (54)  
│                                         │ └┬─ Escherichia coli 1125A (21)  
│                                        ┌┤  └┬─ Escherichia coli O157:H7 EDL933 (1)  
│                                        ││   └─ Escherichia coli 1044A (4)  
│  ┌─────────────────────────────────────┤└┬─ Escherichia coli TA143   
│  │                                     │ └─ Escherichia coli 042 (1)  
└──┤                                     └─ Escherichia coli B088 (16)  
   │                                            ┌─ Escherichia coli (12-332/339) 1827-70   
   │                                           ┌┴─ Escherichia coli (3-320/327) ATCC 8739 (5)  
   └───────────────────────────────────────────┤┌─ Escherichia coli (3-320/327) O111:H- str. 11128   
                                               └┤┌─ Escherichia coli (3-320/327) K12 (22)  
                                                └┤┌─ Escherichia coli (3-320/327) 53638 (1)  
                                                 └┤┌─ Escherichia coli (3-320/327) MS 124-1 (1)  
                                                  └┤┌─ fig|1040638.4.peg.2229 O104:H4 (3-320/327) str. LB226692 (20)  
                                                   └┤┌─ Escherichia coli (3-320/327) B171 (1)  
                                                    └┤┌─ Escherichia coli (3-320/327) MS 69-1   
                                                     └┤ ┌─ Escherichia coli (3-320/327) 042 (6)  
                                                      │┌┴─ Escherichia coli (3-320/327) B185   
                                                      └┤┌─ Escherichia coli (3-320/327) M718   
                                                       └┤┌─ Escherichia coli (3-320/327) O157:H7 EDL933  [2] 
                                                        └┤┌─ Escherichia coli (3-320/327) 1044A (23)  
                                                         └┤ ┌─ Escherichia coli (3-320/327) B354   
                                                          │┌┴─ Escherichia coli (3-320/327) MS 115-1   
                                                          └┤┌─ Escherichia coli (3-320/327) TA280   
                                                           └┤┌─ Escherichia coli (3-320/327) 536 (1)  
                                                            └┤┌─ Escherichia coli (3-320/327) NC101   
                                                             └┤┌─ Escherichia coli (3-320/327) 83972 (5)  
                                                              └┤  ┌─ Escherichia coli (3-320/327) H299   
                                                               │ ┌┴─ Escherichia coli (3-320/327) F11 (3)  
                                                               └┬┴─ Escherichia coli (3-320/327) O83:H1 str. NRG 857C   
                                                                └┬─ Escherichia coli (3-320/327) 2362-75 (2)  
                                                                 └┬─ Escherichia coli (3-320/327) APEC O1 (9)  
                                                                  └─ Escherichia coli (3-320/327) ED1a (2)  
  
Evolved beta-D-galactosidase transcriptional repressor (25)
Transcriptional repressor of the lac operon (21)
Transcriptional regulator YcjW, LacI family, possibly involved in maltodextrin utilization pathway (20)
Trehalose operon transcriptional repressor (12)
AscBF operon repressor (11)
Ribose operon repressor (11)
Mgl repressor and galactose ultrainduction factor GalS, HTH-type transcriptional regulator (11)
Positive regulator of L-idonate catabolism (10)
Transcriptional (co)regulator CytR (10)
Gluconate utilization system Gnt-I transcriptional repressor (9)
Sucrose specific transcriptional regulator CscR, LacI family (9)
Transcriptional regulator, LacI family (5)
Purine nucleotide synthesis repressor (5)
Putative ThuR, regulatory protein for trehalosemaltose transport (2)
Maltose regulon regulatory protein MalI (repressor for malXY) (1)
hypothetical transcriptional regulator YcjW (1)
Others (11)