fig|1040638.4.peg.941
Escherichia coli O104:H4 str. LB226692
M
MSK
I
NQTDID
R
L
I
EL
VGG
R
GNI
A
T
VS
HC
I
TRLRF
V
L
N
Q
PANARPKE
I
E
QLP
M
V
K
G
C
FT
N
AG
Q
F
QVVIG
TN
V
GD
-
YYQ
A
LIAST
G
QAQV
-
D
KEQVKKAARQNMKWHE---
--
QL
I
SHFAE
IF
F
PL
L
P
AL
I
SG
GL
I
LG
FRN
V
I
GDLPMSNG
Q
T
LAQMYPSL
Q
T
I
----
Y
D
FL
WLI
G
E
A
I
F
F
Y
LP
V
G
I
CW
SA
VKK
M
GGT
PIL
G
IV
LG
VT
LV
---
S
P
QLMNAYLL
G
QQLPEVW
-
DF
GMF
S
I
AKVG
Y
QAQ
VIP
A
L
LAG
L
A
L
GV
IE
TR
L
KRIV
P
DYLYLVVV
P
V
CS
L
IL
AVF
LA
H
A
LIGP
F
G
R
M
I
GDG
V
A
FAVRH
L
MTGS
F
APIGA
A
L
F
G
F
L
Y
APL
V
I
TGVH
QTTL
A
ID
L
QMI
--
QSM
G
GTP
V
W
PL
I
AL
S
NI
AQ
A
PP
fig|656419.3.peg.5496
Escherichia coli M718 (1-353/473)
M
MSK
I
NQTDID
R
L
I
EL
VGG
R
GNI
A
T
VS
HC
I
TRLRF
V
L
N
Q
PANARPKE
I
E
QLP
M
V
K
G
C
FT
N
AG
Q
F
QVVIG
TN
V
GD
-
YYQ
A
LIAST
G
QAQV
-
D
KEQVKKAARQNMKWHE---
--
QL
I
SHFAE
IF
F
PL
L
P
AL
I
SG
GL
I
LG
FRN
V
I
GDLPMSNG
Q
T
LAQMYPSL
Q
T
I
----
Y
D
FL
WLI
G
E
A
I
F
F
Y
LP
V
G
I
CW
SA
VKK
M
GGT
PIL
G
IV
LG
VT
LV
---
S
P
QLMNAYLL
G
QQLPEVW
-
DF
GMF
S
I
AKVG
Y
QAQ
VIP
A
L
LAG
L
A
L
GV
IE
TR
L
KRIV
P
DYLYLVVV
P
V
CS
L
IL
AVF
LA
H
A
LIGP
F
G
R
M
I
GDG
V
A
FAVRH
L
MTGS
F
APIGA
A
L
F
G
F
L
Y
APL
V
I
TGVH
QTTL
A
ID
L
QMI
--
QSM
G
GTP
V
W
PL
I
AL
S
NI
AQG
fig|656414.3.peg.4812
Escherichia coli H736 (1-353/473)
M
MSK
I
NQTDID
R
L
I
EL
VGG
R
GNI
A
T
VS
HC
I
TRLRF
V
L
N
Q
PANARPKE
I
E
QLP
M
V
K
G
C
FT
N
AG
Q
F
QVVIG
TN
V
GD
-
YYQ
A
LIAST
G
QAQV
-
D
KEQVKKAARQNMKWHE---
--
QL
I
SHFAE
IF
F
PL
L
P
AL
I
SG
GL
I
LG
FRN
V
I
GDLPMSNG
Q
T
LAQMYPSL
Q
T
I
----
Y
D
FL
WLI
G
E
A
I
F
F
Y
LP
V
G
I
CW
SA
VKK
M
GGT
PIL
G
IV
LG
VT
LV
---
S
P
QLMNAYLL
G
QQLPEVW
-
DF
GMF
S
I
AKVG
Y
QAQ
VIP
A
L
LAG
L
A
L
GV
IE
TR
L
KRIV
P
DYLYLVVV
P
V
CS
L
IL
AVF
LA
H
A
LIGP
F
G
R
M
I
GDG
V
A
FAVRH
L
MTGS
F
APIGA
A
L
F
G
F
L
Y
APL
V
I
TGVH
QTTL
A
ID
L
QMI
--
QSM
G
GTP
V
W
PL
I
AL
S
NI
AQG
fig|216592.1.peg.2692
Escherichia coli 042 (1-353/473)
M
MSK
I
NQTDID
R
L
I
EL
VGG
R
GNI
A
T
VS
HC
I
TRLRF
V
L
N
Q
PANARPKE
I
E
QLP
M
V
K
G
C
FT
N
AG
Q
F
QVVIG
TN
V
GD
-
YYQ
A
LIAST
G
QAQV
-
D
KEQVKKAARQNMKWHE---
--
QL
I
SHFAE
IF
F
PL
L
P
AL
I
SG
GL
I
LG
FRN
V
I
GDLPMSNG
Q
T
LAQMYPSL
Q
T
I
----
Y
D
FL
WLI
G
E
A
I
F
F
Y
LP
V
G
I
CW
SA
VKK
M
GGT
PIL
G
IV
LG
VT
LV
---
S
P
QLMNAYLL
G
QQLPEVW
-
DF
GMF
S
I
AKVG
Y
QAQ
VIP
A
L
LAG
L
A
L
GV
IE
TR
L
KRIV
P
DYLYLVVV
P
V
CS
L
IL
AVF
LA
H
A
LIGP
F
G
R
M
I
GDG
V
A
FAVRH
L
MTGS
F
APIGA
A
L
F
G
F
L
Y
APL
V
I
TGVH
QTTL
A
ID
L
QMI
--
QSM
G
GTP
V
W
PL
I
AL
S
NI
AQG
fig|216592.3.peg.4903
Escherichia coli 042 (1-353/473)
M
MSK
I
NQTDID
R
L
I
EL
VGG
R
GNI
A
T
VS
HC
I
TRLRF
V
L
N
Q
PANARPKE
I
E
QLP
M
V
K
G
C
FT
N
AG
Q
F
QVVIG
TN
V
GD
-
YYQ
A
LIAST
G
QAQV
-
D
KEQVKKAARQNMKWHE---
--
QL
I
SHFAE
IF
F
PL
L
P
AL
I
SG
GL
I
LG
FRN
V
I
GDLPMSNG
Q
T
LAQMYPSL
Q
T
I
----
Y
D
FL
WLI
G
E
A
I
F
F
Y
LP
V
G
I
CW
SA
VKK
M
GGT
PIL
G
IV
LG
VT
LV
---
S
P
QLMNAYLL
G
QQLPEVW
-
DF
GMF
S
I
AKVG
Y
QAQ
VIP
A
L
LAG
L
A
L
GV
IE
TR
L
KRIV
P
DYLYLVVV
P
V
CS
L
IL
AVF
LA
H
A
LIGP
F
G
R
M
I
GDG
V
A
FAVRH
L
MTGS
F
APIGA
A
L
F
G
F
L
Y
APL
V
I
TGVH
QTTL
A
ID
L
QMI
--
QSM
G
GTP
V
W
PL
I
AL
S
NI
AQG
fig|358709.5.peg.2437
Escherichia coli 101-1 (1-353/473)
M
MSK
I
NQTDID
R
L
I
EL
VGG
R
GNI
A
T
VS
HC
I
TRLRF
V
L
N
Q
PANARPKE
I
E
QLP
M
V
K
G
C
FT
N
AG
Q
F
QVVIG
TN
V
GD
-
YYQ
A
LIAST
G
QAQV
-
D
KEQVKKAARQNMKWHE---
--
QL
I
SHFAE
IF
F
PL
L
P
AL
I
SG
GL
I
LG
FRN
V
I
GDLPMSNG
Q
T
LAQMYPSL
Q
T
I
----
Y
D
FL
WLI
G
E
A
I
F
F
Y
LP
V
G
I
CW
SA
VKK
M
GGT
PIL
G
IV
LG
VT
LV
---
S
P
QLMNAYLL
G
QQLPEVW
-
DF
GMF
S
I
AKVG
Y
QAQ
VIP
A
L
LAG
L
A
L
GV
IE
TR
L
KRIV
P
DYLYLVVV
P
V
CS
L
IL
AVF
LA
H
A
LIGP
F
G
R
M
I
GDG
V
A
FAVRH
L
MTGS
F
APIGA
A
L
F
G
F
L
Y
APL
V
I
TGVH
QTTL
A
ID
L
QMI
--
QSM
G
GTP
V
W
PL
I
AL
S
NI
AQG
fig|562.371.peg.3766
Escherichia coli 1044A (1-353/473)
M
MSK
I
NQTDID
R
L
I
EL
VGG
R
GNI
A
T
VS
HC
I
TRLRF
V
L
N
Q
PANARPKE
I
E
QLP
M
V
K
G
C
FT
N
AG
Q
F
QVVIG
TN
V
GD
-
YYQ
A
LIAST
G
QAQV
-
D
KEQVKKAARQNMKWHE---
--
QL
I
SHFAE
IF
F
PL
L
P
AL
I
SG
GL
I
LG
FRN
V
I
GDLPMSNG
Q
T
LAQMYPSL
Q
T
I
----
Y
D
FL
WLI
G
E
A
I
F
F
Y
LP
V
G
I
CW
SA
VKK
M
GGT
PIL
G
IV
LG
VT
LV
---
S
P
QLMNAYLL
G
QQLPEVW
-
DF
GMF
S
I
AKVG
Y
QAQ
VIP
A
L
LAG
L
A
L
GV
IE
TR
L
KRIV
P
DYLYLVVV
P
V
CS
L
IL
AVF
LA
H
A
LIGP
F
G
R
M
I
GDG
V
A
FAVRH
L
MTGS
F
APIGA
A
L
F
G
F
L
Y
APL
V
I
TGVH
QTTL
A
ID
L
QMI
--
QSM
G
GTP
V
W
PL
I
AL
S
NI
AQG
fig|562.373.peg.2435
Escherichia coli 1125A (1-353/473)
M
MSK
I
NQTDID
R
L
I
EL
VGG
R
GNI
A
T
VS
HC
I
TRLRF
V
L
N
Q
PANARPKE
I
E
QLP
M
V
K
G
C
FT
N
AG
Q
F
QVVIG
TN
V
GD
-
YYQ
A
LIAST
G
QAQV
-
D
KEQVKKAARQNMKWHE---
--
QL
I
SHFAE
IF
F
PL
L
P
AL
I
SG
GL
I
LG
FRN
V
I
GDLPMSNG
Q
T
LAQMYPSL
Q
T
I
----
Y
D
FL
WLI
G
E
A
I
F
F
Y
LP
V
G
I
CW
SA
VKK
M
GGT
PIL
G
IV
LG
VT
LV
---
S
P
QLMNAYLL
G
QQLPEVW
-
DF
GMF
S
I
AKVG
Y
QAQ
VIP
A
L
LAG
L
A
L
GV
IE
TR
L
KRIV
P
DYLYLVVV
P
V
CS
L
IL
AVF
LA
H
A
LIGP
F
G
R
M
I
GDG
V
A
FAVRH
L
MTGS
F
APIGA
A
L
F
G
F
L
Y
APL
V
I
TGVH
QTTL
A
ID
L
QMI
--
QSM
G
GTP
V
W
PL
I
AL
S
NI
AQG
fig|562.372.peg.3291
Escherichia coli 1212A (1-353/473)
M
MSK
I
NQTDID
R
L
I
EL
VGG
R
GNI
A
T
VS
HC
I
TRLRF
V
L
N
Q
PANARPKE
I
E
QLP
M
V
K
G
C
FT
N
AG
Q
F
QVVIG
TN
V
GD
-
YYQ
A
LIAST
G
QAQV
-
D
KEQVKKAARQNMKWHE---
--
QL
I
SHFAE
IF
F
PL
L
P
AL
I
SG
GL
I
LG
FRN
V
I
GDLPMSNG
Q
T
LAQMYPSL
Q
T
I
----
Y
D
FL
WLI
G
E
A
I
F
F
Y
LP
V
G
I
CW
SA
VKK
M
GGT
PIL
G
IV
LG
VT
LV
---
S
P
QLMNAYLL
G
QQLPEVW
-
DF
GMF
S
I
AKVG
Y
QAQ
VIP
A
L
LAG
L
A
L
GV
IE
TR
L
KRIV
P
DYLYLVVV
P
V
CS
L
IL
AVF
LA
H
A
LIGP
F
G
R
M
I
GDG
V
A
FAVRH
L
MTGS
F
APIGA
A
L
F
G
F
L
Y
APL
V
I
TGVH
QTTL
A
ID
L
QMI
--
QSM
G
GTP
V
W
PL
I
AL
S
NI
AQG
fig|670888.3.peg.4482
Escherichia coli 1827-70 (1-353/473)
M
MSK
I
NQTDID
R
L
I
EL
VGG
R
GNI
A
T
VS
HC
I
TRLRF
V
L
N
Q
PANARPKE
I
E
QLP
M
V
K
G
C
FT
N
AG
Q
F
QVVIG
TN
V
GD
-
YYQ
A
LIAST
G
QAQV
-
D
KEQVKKAARQNMKWHE---
--
QL
I
SHFAE
IF
F
PL
L
P
AL
I
SG
GL
I
LG
FRN
V
I
GDLPMSNG
Q
T
LAQMYPSL
Q
T
I
----
Y
D
FL
WLI
G
E
A
I
F
F
Y
LP
V
G
I
CW
SA
VKK
M
GGT
PIL
G
IV
LG
VT
LV
---
S
P
QLMNAYLL
G
QQLPEVW
-
DF
GMF
S
I
AKVG
Y
QAQ
VIP
A
L
LAG
L
A
L
GV
IE
TR
L
KRIV
P
DYLYLVVV
P
V
CS
L
IL
AVF
LA
H
A
LIGP
F
G
R
M
I
GDG
V
A
FAVRH
L
MTGS
F
APIGA
A
L
F
G
F
L
Y
APL
V
I
TGVH
QTTL
A
ID
L
QMI
--
QSM
G
GTP
V
W
PL
I
AL
S
NI
AQG
fig|670897.3.peg.1616
Escherichia coli 2362-75 (1-353/473)
M
MSK
I
NQTDID
R
L
I
EL
VGG
R
GNI
A
T
VS
HC
I
TRLRF
V
L
N
Q
PANARPKE
I
E
QLP
M
V
K
G
C
FT
N
AG
Q
F
QVVIG
TN
V
GD
-
YYQ
A
LIAST
G
QAQV
-
D
KEQVKKAARQNMKWHE---
--
QL
I
SHFAE
IF
F
PL
L
P
AL
I
SG
GL
I
LG
FRN
V
I
GDLPMSNG
Q
T
LAQMYPSL
Q
T
I
----
Y
D
FL
WLI
G
E
A
I
F
F
Y
LP
V
G
I
CW
SA
VKK
M
GGT
PIL
G
IV
LG
VT
LV
---
S
P
QLMNAYLL
G
QQLPEVW
-
DF
GMF
S
I
AKVG
Y
QAQ
VIP
A
L
LAG
L
A
L
GV
IE
TR
L
KRIV
P
DYLYLVVV
P
V
CS
L
IL
AVF
LA
H
A
LIGP
F
G
R
M
I
GDG
V
A
FAVRH
L
MTGS
F
APIGA
A
L
F
G
F
L
Y
APL
V
I
TGVH
QTTL
A
ID
L
QMI
--
QSM
G
GTP
V
W
PL
I
AL
S
NI
AQG
fig|344610.3.peg.620
Escherichia coli 53638 (1-353/473)
M
MSK
I
NQTDID
R
L
I
EL
VGG
R
GNI
A
T
VS
HC
I
TRLRF
V
L
N
Q
PANARPKE
I
E
QLP
M
V
K
G
C
FT
N
AG
Q
F
QVVIG
TN
V
GD
-
YYQ
A
LIAST
G
QAQV
-
D
KEQVKKAARQNMKWHE---
--
QL
I
SHFAE
IF
F
PL
L
P
AL
I
SG
GL
I
LG
FRN
V
I
GDLPMSNG
Q
T
LAQMYPSL
Q
T
I
----
Y
D
FL
WLI
G
E
A
I
F
F
Y
LP
V
G
I
CW
SA
VKK
M
GGT
PIL
G
IV
LG
VT
LV
---
S
P
QLMNAYLL
G
QQLPEVW
-
DF
GMF
S
I
AKVG
Y
QAQ
VIP
A
L
LAG
L
A
L
GV
IE
TR
L
KRIV
P
DYLYLVVV
P
V
CS
L
IL
AVF
LA
H
A
LIGP
F
G
R
M
I
GDG
V
A
FAVRH
L
MTGS
F
APIGA
A
L
F
G
F
L
Y
APL
V
I
TGVH
QTTL
A
ID
L
QMI
--
QSM
G
GTP
V
W
PL
I
AL
S
NI
AQG
fig|344610.7.peg.1879
Escherichia coli 53638 (1-353/473)
M
MSK
I
NQTDID
R
L
I
EL
VGG
R
GNI
A
T
VS
HC
I
TRLRF
V
L
N
Q
PANARPKE
I
E
QLP
M
V
K
G
C
FT
N
AG
Q
F
QVVIG
TN
V
GD
-
YYQ
A
LIAST
G
QAQV
-
D
KEQVKKAARQNMKWHE---
--
QL
I
SHFAE
IF
F
PL
L
P
AL
I
SG
GL
I
LG
FRN
V
I
GDLPMSNG
Q
T
LAQMYPSL
Q
T
I
----
Y
D
FL
WLI
G
E
A
I
F
F
Y
LP
V
G
I
CW
SA
VKK
M
GGT
PIL
G
IV
LG
VT
LV
---
S
P
QLMNAYLL
G
QQLPEVW
-
DF
GMF
S
I
AKVG
Y
QAQ
VIP
A
L
LAG
L
A
L
GV
IE
TR
L
KRIV
P
DYLYLVVV
P
V
CS
L
IL
AVF
LA
H
A
LIGP
F
G
R
M
I
GDG
V
A
FAVRH
L
MTGS
F
APIGA
A
L
F
G
F
L
Y
APL
V
I
TGVH
QTTL
A
ID
L
QMI
--
QSM
G
GTP
V
W
PL
I
AL
S
NI
AQG
fig|562.374.peg.5722
Escherichia coli 536A (1-353/473)
M
MSK
I
NQTDID
R
L
I
EL
VGG
R
GNI
A
T
VS
HC
I
TRLRF
V
L
N
Q
PANARPKE
I
E
QLP
M
V
K
G
C
FT
N
AG
Q
F
QVVIG
TN
V
GD
-
YYQ
A
LIAST
G
QAQV
-
D
KEQVKKAARQNMKWHE---
--
QL
I
SHFAE
IF
F
PL
L
P
AL
I
SG
GL
I
LG
FRN
V
I
GDLPMSNG
Q
T
LAQMYPSL
Q
T
I
----
Y
D
FL
WLI
G
E
A
I
F
F
Y
LP
V
G
I
CW
SA
VKK
M
GGT
PIL
G
IV
LG
VT
LV
---
S
P
QLMNAYLL
G
QQLPEVW
-
DF
GMF
S
I
AKVG
Y
QAQ
VIP
A
L
LAG
L
A
L
GV
IE
TR
L
KRIV
P
DYLYLVVV
P
V
CS
L
IL
AVF
LA
H
A
LIGP
F
G
R
M
I
GDG
V
A
FAVRH
L
MTGS
F
APIGA
A
L
F
G
F
L
Y
APL
V
I
TGVH
QTTL
A
ID
L
QMI
--
QSM
G
GTP
V
W
PL
I
AL
S
NI
AQG
fig|585055.6.peg.4821
Escherichia coli 55989 (1-353/473)
M
MSK
I
NQTDID
R
L
I
EL
VGG
R
GNI
A
T
VS
HC
I
TRLRF
V
L
N
Q
PANARPKE
I
E
QLP
M
V
K
G
C
FT
N
AG
Q
F
QVVIG
TN
V
GD
-
YYQ
A
LIAST
G
QAQV
-
D
KEQVKKAARQNMKWHE---
--
QL
I
SHFAE
IF
F
PL
L
P
AL
I
SG
GL
I
LG
FRN
V
I
GDLPMSNG
Q
T
LAQMYPSL
Q
T
I
----
Y
D
FL
WLI
G
E
A
I
F
F
Y
LP
V
G
I
CW
SA
VKK
M
GGT
PIL
G
IV
LG
VT
LV
---
S
P
QLMNAYLL
G
QQLPEVW
-
DF
GMF
S
I
AKVG
Y
QAQ
VIP
A
L
LAG
L
A
L
GV
IE
TR
L
KRIV
P
DYLYLVVV
P
V
CS
L
IL
AVF
LA
H
A
LIGP
F
G
R
M
I
GDG
V
A
FAVRH
L
MTGS
F
APIGA
A
L
F
G
F
L
Y
APL
V
I
TGVH
QTTL
A
ID
L
QMI
--
QSM
G
GTP
V
W
PL
I
AL
S
NI
AQG
fig|585055.8.peg.4825
Escherichia coli 55989 (1-353/473)
M
MSK
I
NQTDID
R
L
I
EL
VGG
R
GNI
A
T
VS
HC
I
TRLRF
V
L
N
Q
PANARPKE
I
E
QLP
M
V
K
G
C
FT
N
AG
Q
F
QVVIG
TN
V
GD
-
YYQ
A
LIAST
G
QAQV
-
D
KEQVKKAARQNMKWHE---
--
QL
I
SHFAE
IF
F
PL
L
P
AL
I
SG
GL
I
LG
FRN
V
I
GDLPMSNG
Q
T
LAQMYPSL
Q
T
I
----
Y
D
FL
WLI
G
E
A
I
F
F
Y
LP
V
G
I
CW
SA
VKK
M
GGT
PIL
G
IV
LG
VT
LV
---
S
P
QLMNAYLL
G
QQLPEVW
-
DF
GMF
S
I
AKVG
Y
QAQ
VIP
A
L
LAG
L
A
L
GV
IE
TR
L
KRIV
P
DYLYLVVV
P
V
CS
L
IL
AVF
LA
H
A
LIGP
F
G
R
M
I
GDG
V
A
FAVRH
L
MTGS
F
APIGA
A
L
F
G
F
L
Y
APL
V
I
TGVH
QTTL
A
ID
L
QMI
--
QSM
G
GTP
V
W
PL
I
AL
S
NI
AQG
fig|550676.3.peg.4517
Escherichia coli B185 (1-353/473)
M
MSK
I
NQTDID
R
L
I
EL
VGG
R
GNI
A
T
VS
HC
I
TRLRF
V
L
N
Q
PANARPKE
I
E
QLP
M
V
K
G
C
FT
N
AG
Q
F
QVVIG
TN
V
GD
-
YYQ
A
LIAST
G
QAQV
-
D
KEQVKKAARQNMKWHE---
--
QL
I
SHFAE
IF
F
PL
L
P
AL
I
SG
GL
I
LG
FRN
V
I
GDLPMSNG
Q
T
LAQMYPSL
Q
T
I
----
Y
D
FL
WLI
G
E
A
I
F
F
Y
LP
V
G
I
CW
SA
VKK
M
GGT
PIL
G
IV
LG
VT
LV
---
S
P
QLMNAYLL
G
QQLPEVW
-
DF
GMF
S
I
AKVG
Y
QAQ
VIP
A
L
LAG
L
A
L
GV
IE
TR
L
KRIV
P
DYLYLVVV
P
V
CS
L
IL
AVF
LA
H
A
LIGP
F
G
R
M
I
GDG
V
A
FAVRH
L
MTGS
F
APIGA
A
L
F
G
F
L
Y
APL
V
I
TGVH
QTTL
A
ID
L
QMI
--
QSM
G
GTP
V
W
PL
I
AL
S
NI
AQG
fig|550677.3.peg.241
Escherichia coli B354 (1-353/473)
M
MSK
I
NQTDID
R
L
I
EL
VGG
R
GNI
A
T
VS
HC
I
TRLRF
V
L
N
Q
PANARPKE
I
E
QLP
M
V
K
G
C
FT
N
AG
Q
F
QVVIG
TN
V
GD
-
YYQ
A
LIAST
G
QAQV
-
D
KEQVKKAARQNMKWHE---
--
QL
I
SHFAE
IF
F
PL
L
P
AL
I
SG
GL
I
LG
FRN
V
I
GDLPMSNG
Q
T
LAQMYPSL
Q
T
I
----
Y
D
FL
WLI
G
E
A
I
F
F
Y
LP
V
G
I
CW
SA
VKK
M
GGT
PIL
G
IV
LG
VT
LV
---
S
P
QLMNAYLL
G
QQLPEVW
-
DF
GMF
S
I
AKVG
Y
QAQ
VIP
A
L
LAG
L
A
L
GV
IE
TR
L
KRIV
P
DYLYLVVV
P
V
CS
L
IL
AVF
LA
H
A
LIGP
F
G
R
M
I
GDG
V
A
FAVRH
L
MTGS
F
APIGA
A
L
F
G
F
L
Y
APL
V
I
TGVH
QTTL
A
ID
L
QMI
--
QSM
G
GTP
V
W
PL
I
AL
S
NI
AQG
fig|340186.3.peg.3021
Escherichia coli E110019 (1-353/473)
M
MSK
I
NQTDID
R
L
I
EL
VGG
R
GNI
A
T
VS
HC
I
TRLRF
V
L
N
Q
PANARPKE
I
E
QLP
M
V
K
G
C
FT
N
AG
Q
F
QVVIG
TN
V
GD
-
YYQ
A
LIAST
G
QAQV
-
D
KEQVKKAARQNMKWHE---
--
QL
I
SHFAE
IF
F
PL
L
P
AL
I
SG
GL
I
LG
FRN
V
I
GDLPMSNG
Q
T
LAQMYPSL
Q
T
I
----
Y
D
FL
WLI
G
E
A
I
F
F
Y
LP
V
G
I
CW
SA
VKK
M
GGT
PIL
G
IV
LG
VT
LV
---
S
P
QLMNAYLL
G
QQLPEVW
-
DF
GMF
S
I
AKVG
Y
QAQ
VIP
A
L
LAG
L
A
L
GV
IE
TR
L
KRIV
P
DYLYLVVV
P
V
CS
L
IL
AVF
LA
H
A
LIGP
F
G
R
M
I
GDG
V
A
FAVRH
L
MTGS
F
APIGA
A
L
F
G
F
L
Y
APL
V
I
TGVH
QTTL
A
ID
L
QMI
--
QSM
G
GTP
V
W
PL
I
AL
S
NI
AQG
fig|340186.5.peg.3147
Escherichia coli E110019 (1-353/473)
M
MSK
I
NQTDID
R
L
I
EL
VGG
R
GNI
A
T
VS
HC
I
TRLRF
V
L
N
Q
PANARPKE
I
E
QLP
M
V
K
G
C
FT
N
AG
Q
F
QVVIG
TN
V
GD
-
YYQ
A
LIAST
G
QAQV
-
D
KEQVKKAARQNMKWHE---
--
QL
I
SHFAE
IF
F
PL
L
P
AL
I
SG
GL
I
LG
FRN
V
I
GDLPMSNG
Q
T
LAQMYPSL
Q
T
I
----
Y
D
FL
WLI
G
E
A
I
F
F
Y
LP
V
G
I
CW
SA
VKK
M
GGT
PIL
G
IV
LG
VT
LV
---
S
P
QLMNAYLL
G
QQLPEVW
-
DF
GMF
S
I
AKVG
Y
QAQ
VIP
A
L
LAG
L
A
L
GV
IE
TR
L
KRIV
P
DYLYLVVV
P
V
CS
L
IL
AVF
LA
H
A
LIGP
F
G
R
M
I
GDG
V
A
FAVRH
L
MTGS
F
APIGA
A
L
F
G
F
L
Y
APL
V
I
TGVH
QTTL
A
ID
L
QMI
--
QSM
G
GTP
V
W
PL
I
AL
S
NI
AQG
fig|585397.7.peg.5064
Escherichia coli ED1a (1-353/473)
M
MSK
I
NQTDID
R
L
I
EL
VGG
R
GNI
A
T
VS
HC
I
TRLRF
V
L
N
Q
PANARPKE
I
E
QLP
M
V
K
G
C
FT
N
AG
Q
F
QVVIG
TN
V
GD
-
YYQ
A
LIAST
G
QAQV
-
D
KEQVKKAARQNMKWHE---
--
QL
I
SHFAE
IF
F
PL
L
P
AL
I
SG
GL
I
LG
FRN
V
I
GDLPMSNG
Q
T
LAQMYPSL
Q
T
I
----
Y
D
FL
WLI
G
E
A
I
F
F
Y
LP
V
G
I
CW
SA
VKK
M
GGT
PIL
G
IV
LG
VT
LV
---
S
P
QLMNAYLL
G
QQLPEVW
-
DF
GMF
S
I
AKVG
Y
QAQ
VIP
A
L
LAG
L
A
L
GV
IE
TR
L
KRIV
P
DYLYLVVV
P
V
CS
L
IL
AVF
LA
H
A
LIGP
F
G
R
M
I
GDG
V
A
FAVRH
L
MTGS
F
APIGA
A
L
F
G
F
L
Y
APL
V
I
TGVH
QTTL
A
ID
L
QMI
--
QSM
G
GTP
V
W
PL
I
AL
S
NI
AQG
fig|585397.9.peg.5066
Escherichia coli ED1a (1-353/473)
M
MSK
I
NQTDID
R
L
I
EL
VGG
R
GNI
A
T
VS
HC
I
TRLRF
V
L
N
Q
PANARPKE
I
E
QLP
M
V
K
G
C
FT
N
AG
Q
F
QVVIG
TN
V
GD
-
YYQ
A
LIAST
G
QAQV
-
D
KEQVKKAARQNMKWHE---
--
QL
I
SHFAE
IF
F
PL
L
P
AL
I
SG
GL
I
LG
FRN
V
I
GDLPMSNG
Q
T
LAQMYPSL
Q
T
I
----
Y
D
FL
WLI
G
E
A
I
F
F
Y
LP
V
G
I
CW
SA
VKK
M
GGT
PIL
G
IV
LG
VT
LV
---
S
P
QLMNAYLL
G
QQLPEVW
-
DF
GMF
S
I
AKVG
Y
QAQ
VIP
A
L
LAG
L
A
L
GV
IE
TR
L
KRIV
P
DYLYLVVV
P
V
CS
L
IL
AVF
LA
H
A
LIGP
F
G
R
M
I
GDG
V
A
FAVRH
L
MTGS
F
APIGA
A
L
F
G
F
L
Y
APL
V
I
TGVH
QTTL
A
ID
L
QMI
--
QSM
G
GTP
V
W
PL
I
AL
S
NI
AQG
fig|316401.4.peg.5210
Escherichia coli ETEC H10407 (1-353/473)
M
MSK
I
NQTDID
R
L
I
EL
VGG
R
GNI
A
T
VS
HC
I
TRLRF
V
L
N
Q
PANARPKE
I
E
QLP
M
V
K
G
C
FT
N
AG
Q
F
QVVIG
TN
V
GD
-
YYQ
A
LIAST
G
QAQV
-
D
KEQVKKAARQNMKWHE---
--
QL
I
SHFAE
IF
F
PL
L
P
AL
I
SG
GL
I
LG
FRN
V
I
GDLPMSNG
Q
T
LAQMYPSL
Q
T
I
----
Y
D
FL
WLI
G
E
A
I
F
F
Y
LP
V
G
I
CW
SA
VKK
M
GGT
PIL
G
IV
LG
VT
LV
---
S
P
QLMNAYLL
G
QQLPEVW
-
DF
GMF
S
I
AKVG
Y
QAQ
VIP
A
L
LAG
L
A
L
GV
IE
TR
L
KRIV
P
DYLYLVVV
P
V
CS
L
IL
AVF
LA
H
A
LIGP
F
G
R
M
I
GDG
V
A
FAVRH
L
MTGS
F
APIGA
A
L
F
G
F
L
Y
APL
V
I
TGVH
QTTL
A
ID
L
QMI
--
QSM
G
GTP
V
W
PL
I
AL
S
NI
AQG
fig|585034.4.peg.4350
Escherichia coli IAI1 (1-353/473)
M
MSK
I
NQTDID
R
L
I
EL
VGG
R
GNI
A
T
VS
HC
I
TRLRF
V
L
N
Q
PANARPKE
I
E
QLP
M
V
K
G
C
FT
N
AG
Q
F
QVVIG
TN
V
GD
-
YYQ
A
LIAST
G
QAQV
-
D
KEQVKKAARQNMKWHE---
--
QL
I
SHFAE
IF
F
PL
L
P
AL
I
SG
GL
I
LG
FRN
V
I
GDLPMSNG
Q
T
LAQMYPSL
Q
T
I
----
Y
D
FL
WLI
G
E
A
I
F
F
Y
LP
V
G
I
CW
SA
VKK
M
GGT
PIL
G
IV
LG
VT
LV
---
S
P
QLMNAYLL
G
QQLPEVW
-
DF
GMF
S
I
AKVG
Y
QAQ
VIP
A
L
LAG
L
A
L
GV
IE
TR
L
KRIV
P
DYLYLVVV
P
V
CS
L
IL
AVF
LA
H
A
LIGP
F
G
R
M
I
GDG
V
A
FAVRH
L
MTGS
F
APIGA
A
L
F
G
F
L
Y
APL
V
I
TGVH
QTTL
A
ID
L
QMI
--
QSM
G
GTP
V
W
PL
I
AL
S
NI
AQG
fig|585034.5.peg.4347
Escherichia coli IAI1 (1-353/473)
M
MSK
I
NQTDID
R
L
I
EL
VGG
R
GNI
A
T
VS
HC
I
TRLRF
V
L
N
Q
PANARPKE
I
E
QLP
M
V
K
G
C
FT
N
AG
Q
F
QVVIG
TN
V
GD
-
YYQ
A
LIAST
G
QAQV
-
D
KEQVKKAARQNMKWHE---
--
QL
I
SHFAE
IF
F
PL
L
P
AL
I
SG
GL
I
LG
FRN
V
I
GDLPMSNG
Q
T
LAQMYPSL
Q
T
I
----
Y
D
FL
WLI
G
E
A
I
F
F
Y
LP
V
G
I
CW
SA
VKK
M
GGT
PIL
G
IV
LG
VT
LV
---
S
P
QLMNAYLL
G
QQLPEVW
-
DF
GMF
S
I
AKVG
Y
QAQ
VIP
A
L
LAG
L
A
L
GV
IE
TR
L
KRIV
P
DYLYLVVV
P
V
CS
L
IL
AVF
LA
H
A
LIGP
F
G
R
M
I
GDG
V
A
FAVRH
L
MTGS
F
APIGA
A
L
F
G
F
L
Y
APL
V
I
TGVH
QTTL
A
ID
L
QMI
--
QSM
G
GTP
V
W
PL
I
AL
S
NI
AQG
fig|656417.3.peg.5447
Escherichia coli M605 (1-353/473)
M
MSK
I
NQTDID
R
L
I
EL
VGG
R
GNI
A
T
VS
HC
I
TRLRF
V
L
N
Q
PANARPKE
I
E
QLP
M
V
K
G
C
FT
N
AG
Q
F
QVVIG
TN
V
GD
-
YYQ
A
LIAST
G
QAQV
-
D
KEQVKKAARQNMKWHE---
--
QL
I
SHFAE
IF
F
PL
L
P
AL
I
SG
GL
I
LG
FRN
V
I
GDLPMSNG
Q
T
LAQMYPSL
Q
T
I
----
Y
D
FL
WLI
G
E
A
I
F
F
Y
LP
V
G
I
CW
SA
VKK
M
GGT
PIL
G
IV
LG
VT
LV
---
S
P
QLMNAYLL
G
QQLPEVW
-
DF
GMF
S
I
AKVG
Y
QAQ
VIP
A
L
LAG
L
A
L
GV
IE
TR
L
KRIV
P
DYLYLVVV
P
V
CS
L
IL
AVF
LA
H
A
LIGP
F
G
R
M
I
GDG
V
A
FAVRH
L
MTGS
F
APIGA
A
L
F
G
F
L
Y
APL
V
I
TGVH
QTTL
A
ID
L
QMI
--
QSM
G
GTP
V
W
PL
I
AL
S
NI
AQG
fig|679207.4.peg.3489
Escherichia coli MS 107-1 (1-353/473)
M
MSK
I
NQTDID
R
L
I
EL
VGG
R
GNI
A
T
VS
HC
I
TRLRF
V
L
N
Q
PANARPKE
I
E
QLP
M
V
K
G
C
FT
N
AG
Q
F
QVVIG
TN
V
GD
-
YYQ
A
LIAST
G
QAQV
-
D
KEQVKKAARQNMKWHE---
--
QL
I
SHFAE
IF
F
PL
L
P
AL
I
SG
GL
I
LG
FRN
V
I
GDLPMSNG
Q
T
LAQMYPSL
Q
T
I
----
Y
D
FL
WLI
G
E
A
I
F
F
Y
LP
V
G
I
CW
SA
VKK
M
GGT
PIL
G
IV
LG
VT
LV
---
S
P
QLMNAYLL
G
QQLPEVW
-
DF
GMF
S
I
AKVG
Y
QAQ
VIP
A
L
LAG
L
A
L
GV
IE
TR
L
KRIV
P
DYLYLVVV
P
V
CS
L
IL
AVF
LA
H
A
LIGP
F
G
R
M
I
GDG
V
A
FAVRH
L
MTGS
F
APIGA
A
L
F
G
F
L
Y
APL
V
I
TGVH
QTTL
A
ID
L
QMI
--
QSM
G
GTP
V
W
PL
I
AL
S
NI
AQG
fig|749538.3.peg.3420
Escherichia coli MS 116-1 (1-353/473)
M
MSK
I
NQTDID
R
L
I
EL
VGG
R
GNI
A
T
VS
HC
I
TRLRF
V
L
N
Q
PANARPKE
I
E
QLP
M
V
K
G
C
FT
N
AG
Q
F
QVVIG
TN
V
GD
-
YYQ
A
LIAST
G
QAQV
-
D
KEQVKKAARQNMKWHE---
--
QL
I
SHFAE
IF
F
PL
L
P
AL
I
SG
GL
I
LG
FRN
V
I
GDLPMSNG
Q
T
LAQMYPSL
Q
T
I
----
Y
D
FL
WLI
G
E
A
I
F
F
Y
LP
V
G
I
CW
SA
VKK
M
GGT
PIL
G
IV
LG
VT
LV
---
S
P
QLMNAYLL
G
QQLPEVW
-
DF
GMF
S
I
AKVG
Y
QAQ
VIP
A
L
LAG
L
A
L
GV
IE
TR
L
KRIV
P
DYLYLVVV
P
V
CS
L
IL
AVF
LA
H
A
LIGP
F
G
R
M
I
GDG
V
A
FAVRH
L
MTGS
F
APIGA
A
L
F
G
F
L
Y
APL
V
I
TGVH
QTTL
A
ID
L
QMI
--
QSM
G
GTP
V
W
PL
I
AL
S
NI
AQG
fig|679205.4.peg.3184
Escherichia coli MS 124-1 (1-353/473)
M
MSK
I
NQTDID
R
L
I
EL
VGG
R
GNI
A
T
VS
HC
I
TRLRF
V
L
N
Q
PANARPKE
I
E
QLP
M
V
K
G
C
FT
N
AG
Q
F
QVVIG
TN
V
GD
-
YYQ
A
LIAST
G
QAQV
-
D
KEQVKKAARQNMKWHE---
--
QL
I
SHFAE
IF
F
PL
L
P
AL
I
SG
GL
I
LG
FRN
V
I
GDLPMSNG
Q
T
LAQMYPSL
Q
T
I
----
Y
D
FL
WLI
G
E
A
I
F
F
Y
LP
V
G
I
CW
SA
VKK
M
GGT
PIL
G
IV
LG
VT
LV
---
S
P
QLMNAYLL
G
QQLPEVW
-
DF
GMF
S
I
AKVG
Y
QAQ
VIP
A
L
LAG
L
A
L
GV
IE
TR
L
KRIV
P
DYLYLVVV
P
V
CS
L
IL
AVF
LA
H
A
LIGP
F
G
R
M
I
GDG
V
A
FAVRH
L
MTGS
F
APIGA
A
L
F
G
F
L
Y
APL
V
I
TGVH
QTTL
A
ID
L
QMI
--
QSM
G
GTP
V
W
PL
I
AL
S
NI
AQG
fig|749544.3.peg.2815
Escherichia coli MS 175-1 (1-353/473)
M
MSK
I
NQTDID
R
L
I
EL
VGG
R
GNI
A
T
VS
HC
I
TRLRF
V
L
N
Q
PANARPKE
I
E
QLP
M
V
K
G
C
FT
N
AG
Q
F
QVVIG
TN
V
GD
-
YYQ
A
LIAST
G
QAQV
-
D
KEQVKKAARQNMKWHE---
--
QL
I
SHFAE
IF
F
PL
L
P
AL
I
SG
GL
I
LG
FRN
V
I
GDLPMSNG
Q
T
LAQMYPSL
Q
T
I
----
Y
D
FL
WLI
G
E
A
I
F
F
Y
LP
V
G
I
CW
SA
VKK
M
GGT
PIL
G
IV
LG
VT
LV
---
S
P
QLMNAYLL
G
QQLPEVW
-
DF
GMF
S
I
AKVG
Y
QAQ
VIP
A
L
LAG
L
A
L
GV
IE
TR
L
KRIV
P
DYLYLVVV
P
V
CS
L
IL
AVF
LA
H
A
LIGP
F
G
R
M
I
GDG
V
A
FAVRH
L
MTGS
F
APIGA
A
L
F
G
F
L
Y
APL
V
I
TGVH
QTTL
A
ID
L
QMI
--
QSM
G
GTP
V
W
PL
I
AL
S
NI
AQG
fig|749545.3.peg.1041
Escherichia coli MS 182-1 (1-353/473)
M
MSK
I
NQTDID
R
L
I
EL
VGG
R
GNI
A
T
VS
HC
I
TRLRF
V
L
N
Q
PANARPKE
I
E
QLP
M
V
K
G
C
FT
N
AG
Q
F
QVVIG
TN
V
GD
-
YYQ
A
LIAST
G
QAQV
-
D
KEQVKKAARQNMKWHE---
--
QL
I
SHFAE
IF
F
PL
L
P
AL
I
SG
GL
I
LG
FRN
V
I
GDLPMSNG
Q
T
LAQMYPSL
Q
T
I
----
Y
D
FL
WLI
G
E
A
I
F
F
Y
LP
V
G
I
CW
SA
VKK
M
GGT
PIL
G
IV
LG
VT
LV
---
S
P
QLMNAYLL
G
QQLPEVW
-
DF
GMF
S
I
AKVG
Y
QAQ
VIP
A
L
LAG
L
A
L
GV
IE
TR
L
KRIV
P
DYLYLVVV
P
V
CS
L
IL
AVF
LA
H
A
LIGP
F
G
R
M
I
GDG
V
A
FAVRH
L
MTGS
F
APIGA
A
L
F
G
F
L
Y
APL
V
I
TGVH
QTTL
A
ID
L
QMI
--
QSM
G
GTP
V
W
PL
I
AL
S
NI
AQG
fig|749547.3.peg.427
Escherichia coli MS 187-1 (1-353/473)
M
MSK
I
NQTDID
R
L
I
EL
VGG
R
GNI
A
T
VS
HC
I
TRLRF
V
L
N
Q
PANARPKE
I
E
QLP
M
V
K
G
C
FT
N
AG
Q
F
QVVIG
TN
V
GD
-
YYQ
A
LIAST
G
QAQV
-
D
KEQVKKAARQNMKWHE---
--
QL
I
SHFAE
IF
F
PL
L
P
AL
I
SG
GL
I
LG
FRN
V
I
GDLPMSNG
Q
T
LAQMYPSL
Q
T
I
----
Y
D
FL
WLI
G
E
A
I
F
F
Y
LP
V
G
I
CW
SA
VKK
M
GGT
PIL
G
IV
LG
VT
LV
---
S
P
QLMNAYLL
G
QQLPEVW
-
DF
GMF
S
I
AKVG
Y
QAQ
VIP
A
L
LAG
L
A
L
GV
IE
TR
L
KRIV
P
DYLYLVVV
P
V
CS
L
IL
AVF
LA
H
A
LIGP
F
G
R
M
I
GDG
V
A
FAVRH
L
MTGS
F
APIGA
A
L
F
G
F
L
Y
APL
V
I
TGVH
QTTL
A
ID
L
QMI
--
QSM
G
GTP
V
W
PL
I
AL
S
NI
AQG
fig|749548.3.peg.3806
Escherichia coli MS 196-1 (1-353/473)
M
MSK
I
NQTDID
R
L
I
EL
VGG
R
GNI
A
T
VS
HC
I
TRLRF
V
L
N
Q
PANARPKE
I
E
QLP
M
V
K
G
C
FT
N
AG
Q
F
QVVIG
TN
V
GD
-
YYQ
A
LIAST
G
QAQV
-
D
KEQVKKAARQNMKWHE---
--
QL
I
SHFAE
IF
F
PL
L
P
AL
I
SG
GL
I
LG
FRN
V
I
GDLPMSNG
Q
T
LAQMYPSL
Q
T
I
----
Y
D
FL
WLI
G
E
A
I
F
F
Y
LP
V
G
I
CW
SA
VKK
M
GGT
PIL
G
IV
LG
VT
LV
---
S
P
QLMNAYLL
G
QQLPEVW
-
DF
GMF
S
I
AKVG
Y
QAQ
VIP
A
L
LAG
L
A
L
GV
IE
TR
L
KRIV
P
DYLYLVVV
P
V
CS
L
IL
AVF
LA
H
A
LIGP
F
G
R
M
I
GDG
V
A
FAVRH
L
MTGS
F
APIGA
A
L
F
G
F
L
Y
APL
V
I
TGVH
QTTL
A
ID
L
QMI
--
QSM
G
GTP
V
W
PL
I
AL
S
NI
AQG
fig|749527.3.peg.871
Escherichia coli MS 21-1 (1-353/473)
M
MSK
I
NQTDID
R
L
I
EL
VGG
R
GNI
A
T
VS
HC
I
TRLRF
V
L
N
Q
PANARPKE
I
E
QLP
M
V
K
G
C
FT
N
AG
Q
F
QVVIG
TN
V
GD
-
YYQ
A
LIAST
G
QAQV
-
D
KEQVKKAARQNMKWHE---
--
QL
I
SHFAE
IF
F
PL
L
P
AL
I
SG
GL
I
LG
FRN
V
I
GDLPMSNG
Q
T
LAQMYPSL
Q
T
I
----
Y
D
FL
WLI
G
E
A
I
F
F
Y
LP
V
G
I
CW
SA
VKK
M
GGT
PIL
G
IV
LG
VT
LV
---
S
P
QLMNAYLL
G
QQLPEVW
-
DF
GMF
S
I
AKVG
Y
QAQ
VIP
A
L
LAG
L
A
L
GV
IE
TR
L
KRIV
P
DYLYLVVV
P
V
CS
L
IL
AVF
LA
H
A
LIGP
F
G
R
M
I
GDG
V
A
FAVRH
L
MTGS
F
APIGA
A
L
F
G
F
L
Y
APL
V
I
TGVH
QTTL
A
ID
L
QMI
--
QSM
G
GTP
V
W
PL
I
AL
S
NI
AQG
fig|749532.3.peg.3728
Escherichia coli MS 78-1 (1-353/473)
M
MSK
I
NQTDID
R
L
I
EL
VGG
R
GNI
A
T
VS
HC
I
TRLRF
V
L
N
Q
PANARPKE
I
E
QLP
M
V
K
G
C
FT
N
AG
Q
F
QVVIG
TN
V
GD
-
YYQ
A
LIAST
G
QAQV
-
D
KEQVKKAARQNMKWHE---
--
QL
I
SHFAE
IF
F
PL
L
P
AL
I
SG
GL
I
LG
FRN
V
I
GDLPMSNG
Q
T
LAQMYPSL
Q
T
I
----
Y
D
FL
WLI
G
E
A
I
F
F
Y
LP
V
G
I
CW
SA
VKK
M
GGT
PIL
G
IV
LG
VT
LV
---
S
P
QLMNAYLL
G
QQLPEVW
-
DF
GMF
S
I
AKVG
Y
QAQ
VIP
A
L
LAG
L
A
L
GV
IE
TR
L
KRIV
P
DYLYLVVV
P
V
CS
L
IL
AVF
LA
H
A
LIGP
F
G
R
M
I
GDG
V
A
FAVRH
L
MTGS
F
APIGA
A
L
F
G
F
L
Y
APL
V
I
TGVH
QTTL
A
ID
L
QMI
--
QSM
G
GTP
V
W
PL
I
AL
S
NI
AQG
fig|749533.3.peg.3873
Escherichia coli MS 84-1 (1-353/473)
M
MSK
I
NQTDID
R
L
I
EL
VGG
R
GNI
A
T
VS
HC
I
TRLRF
V
L
N
Q
PANARPKE
I
E
QLP
M
V
K
G
C
FT
N
AG
Q
F
QVVIG
TN
V
GD
-
YYQ
A
LIAST
G
QAQV
-
D
KEQVKKAARQNMKWHE---
--
QL
I
SHFAE
IF
F
PL
L
P
AL
I
SG
GL
I
LG
FRN
V
I
GDLPMSNG
Q
T
LAQMYPSL
Q
T
I
----
Y
D
FL
WLI
G
E
A
I
F
F
Y
LP
V
G
I
CW
SA
VKK
M
GGT
PIL
G
IV
LG
VT
LV
---
S
P
QLMNAYLL
G
QQLPEVW
-
DF
GMF
S
I
AKVG
Y
QAQ
VIP
A
L
LAG
L
A
L
GV
IE
TR
L
KRIV
P
DYLYLVVV
P
V
CS
L
IL
AVF
LA
H
A
LIGP
F
G
R
M
I
GDG
V
A
FAVRH
L
MTGS
F
APIGA
A
L
F
G
F
L
Y
APL
V
I
TGVH
QTTL
A
ID
L
QMI
--
QSM
G
GTP
V
W
PL
I
AL
S
NI
AQG
fig|753642.3.peg.3799
Escherichia coli NC101 (1-353/473)
M
MSK
I
NQTDID
R
L
I
EL
VGG
R
GNI
A
T
VS
HC
I
TRLRF
V
L
N
Q
PANARPKE
I
E
QLP
M
V
K
G
C
FT
N
AG
Q
F
QVVIG
TN
V
GD
-
YYQ
A
LIAST
G
QAQV
-
D
KEQVKKAARQNMKWHE---
--
QL
I
SHFAE
IF
F
PL
L
P
AL
I
SG
GL
I
LG
FRN
V
I
GDLPMSNG
Q
T
LAQMYPSL
Q
T
I
----
Y
D
FL
WLI
G
E
A
I
F
F
Y
LP
V
G
I
CW
SA
VKK
M
GGT
PIL
G
IV
LG
VT
LV
---
S
P
QLMNAYLL
G
QQLPEVW
-
DF
GMF
S
I
AKVG
Y
QAQ
VIP
A
L
LAG
L
A
L
GV
IE
TR
L
KRIV
P
DYLYLVVV
P
V
CS
L
IL
AVF
LA
H
A
LIGP
F
G
R
M
I
GDG
V
A
FAVRH
L
MTGS
F
APIGA
A
L
F
G
F
L
Y
APL
V
I
TGVH
QTTL
A
ID
L
QMI
--
QSM
G
GTP
V
W
PL
I
AL
S
NI
AQG
fig|83334.1.peg.5196
Escherichia coli O157:H7 (1-353/473)
M
MSK
I
NQTDID
R
L
I
EL
VGG
R
GNI
A
T
VS
HC
I
TRLRF
V
L
N
Q
PANARPKE
I
E
QLP
M
V
K
G
C
FT
N
AG
Q
F
QVVIG
TN
V
GD
-
YYQ
A
LIAST
G
QAQV
-
D
KEQVKKAARQNMKWHE---
--
QL
I
SHFAE
IF
F
PL
L
P
AL
I
SG
GL
I
LG
FRN
V
I
GDLPMSNG
Q
T
LAQMYPSL
Q
T
I
----
Y
D
FL
WLI
G
E
A
I
F
F
Y
LP
V
G
I
CW
SA
VKK
M
GGT
PIL
G
IV
LG
VT
LV
---
S
P
QLMNAYLL
G
QQLPEVW
-
DF
GMF
S
I
AKVG
Y
QAQ
VIP
A
L
LAG
L
A
L
GV
IE
TR
L
KRIV
P
DYLYLVVV
P
V
CS
L
IL
AVF
LA
H
A
LIGP
F
G
R
M
I
GDG
V
A
FAVRH
L
MTGS
F
APIGA
A
L
F
G
F
L
Y
APL
V
I
TGVH
QTTL
A
ID
L
QMI
--
QSM
G
GTP
V
W
PL
I
AL
S
NI
AQG
fig|155864.1.peg.5179
Escherichia coli O157:H7 EDL933 (1-353/473)
M
MSK
I
NQTDID
R
L
I
EL
VGG
R
GNI
A
T
VS
HC
I
TRLRF
V
L
N
Q
PANARPKE
I
E
QLP
M
V
K
G
C
FT
N
AG
Q
F
QVVIG
TN
V
GD
-
YYQ
A
LIAST
G
QAQV
-
D
KEQVKKAARQNMKWHE---
--
QL
I
SHFAE
IF
F
PL
L
P
AL
I
SG
GL
I
LG
FRN
V
I
GDLPMSNG
Q
T
LAQMYPSL
Q
T
I
----
Y
D
FL
WLI
G
E
A
I
F
F
Y
LP
V
G
I
CW
SA
VKK
M
GGT
PIL
G
IV
LG
VT
LV
---
S
P
QLMNAYLL
G
QQLPEVW
-
DF
GMF
S
I
AKVG
Y
QAQ
VIP
A
L
LAG
L
A
L
GV
IE
TR
L
KRIV
P
DYLYLVVV
P
V
CS
L
IL
AVF
LA
H
A
LIGP
F
G
R
M
I
GDG
V
A
FAVRH
L
MTGS
F
APIGA
A
L
F
G
F
L
Y
APL
V
I
TGVH
QTTL
A
ID
L
QMI
--
QSM
G
GTP
V
W
PL
I
AL
S
NI
AQG
fig|155864.8.peg.5169
Escherichia coli O157:H7 EDL933 (1-353/473)
M
MSK
I
NQTDID
R
L
I
EL
VGG
R
GNI
A
T
VS
HC
I
TRLRF
V
L
N
Q
PANARPKE
I
E
QLP
M
V
K
G
C
FT
N
AG
Q
F
QVVIG
TN
V
GD
-
YYQ
A
LIAST
G
QAQV
-
D
KEQVKKAARQNMKWHE---
--
QL
I
SHFAE
IF
F
PL
L
P
AL
I
SG
GL
I
LG
FRN
V
I
GDLPMSNG
Q
T
LAQMYPSL
Q
T
I
----
Y
D
FL
WLI
G
E
A
I
F
F
Y
LP
V
G
I
CW
SA
VKK
M
GGT
PIL
G
IV
LG
VT
LV
---
S
P
QLMNAYLL
G
QQLPEVW
-
DF
GMF
S
I
AKVG
Y
QAQ
VIP
A
L
LAG
L
A
L
GV
IE
TR
L
KRIV
P
DYLYLVVV
P
V
CS
L
IL
AVF
LA
H
A
LIGP
F
G
R
M
I
GDG
V
A
FAVRH
L
MTGS
F
APIGA
A
L
F
G
F
L
Y
APL
V
I
TGVH
QTTL
A
ID
L
QMI
--
QSM
G
GTP
V
W
PL
I
AL
S
NI
AQG
fig|444454.5.peg.4310
Escherichia coli O157:H7 str. EC4024 (1-353/473)
M
MSK
I
NQTDID
R
L
I
EL
VGG
R
GNI
A
T
VS
HC
I
TRLRF
V
L
N
Q
PANARPKE
I
E
QLP
M
V
K
G
C
FT
N
AG
Q
F
QVVIG
TN
V
GD
-
YYQ
A
LIAST
G
QAQV
-
D
KEQVKKAARQNMKWHE---
--
QL
I
SHFAE
IF
F
PL
L
P
AL
I
SG
GL
I
LG
FRN
V
I
GDLPMSNG
Q
T
LAQMYPSL
Q
T
I
----
Y
D
FL
WLI
G
E
A
I
F
F
Y
LP
V
G
I
CW
SA
VKK
M
GGT
PIL
G
IV
LG
VT
LV
---
S
P
QLMNAYLL
G
QQLPEVW
-
DF
GMF
S
I
AKVG
Y
QAQ
VIP
A
L
LAG
L
A
L
GV
IE
TR
L
KRIV
P
DYLYLVVV
P
V
CS
L
IL
AVF
LA
H
A
LIGP
F
G
R
M
I
GDG
V
A
FAVRH
L
MTGS
F
APIGA
A
L
F
G
F
L
Y
APL
V
I
TGVH
QTTL
A
ID
L
QMI
--
QSM
G
GTP
V
W
PL
I
AL
S
NI
AQG
fig|444449.5.peg.3762
Escherichia coli O157:H7 str. EC4042 (1-353/473)
M
MSK
I
NQTDID
R
L
I
EL
VGG
R
GNI
A
T
VS
HC
I
TRLRF
V
L
N
Q
PANARPKE
I
E
QLP
M
V
K
G
C
FT
N
AG
Q
F
QVVIG
TN
V
GD
-
YYQ
A
LIAST
G
QAQV
-
D
KEQVKKAARQNMKWHE---
--
QL
I
SHFAE
IF
F
PL
L
P
AL
I
SG
GL
I
LG
FRN
V
I
GDLPMSNG
Q
T
LAQMYPSL
Q
T
I
----
Y
D
FL
WLI
G
E
A
I
F
F
Y
LP
V
G
I
CW
SA
VKK
M
GGT
PIL
G
IV
LG
VT
LV
---
S
P
QLMNAYLL
G
QQLPEVW
-
DF
GMF
S
I
AKVG
Y
QAQ
VIP
A
L
LAG
L
A
L
GV
IE
TR
L
KRIV
P
DYLYLVVV
P
V
CS
L
IL
AVF
LA
H
A
LIGP
F
G
R
M
I
GDG
V
A
FAVRH
L
MTGS
F
APIGA
A
L
F
G
F
L
Y
APL
V
I
TGVH
QTTL
A
ID
L
QMI
--
QSM
G
GTP
V
W
PL
I
AL
S
NI
AQG
fig|444448.5.peg.2520
Escherichia coli O157:H7 str. EC4045 (1-353/473)
M
MSK
I
NQTDID
R
L
I
EL
VGG
R
GNI
A
T
VS
HC
I
TRLRF
V
L
N
Q
PANARPKE
I
E
QLP
M
V
K
G
C
FT
N
AG
Q
F
QVVIG
TN
V
GD
-
YYQ
A
LIAST
G
QAQV
-
D
KEQVKKAARQNMKWHE---
--
QL
I
SHFAE
IF
F
PL
L
P
AL
I
SG
GL
I
LG
FRN
V
I
GDLPMSNG
Q
T
LAQMYPSL
Q
T
I
----
Y
D
FL
WLI
G
E
A
I
F
F
Y
LP
V
G
I
CW
SA
VKK
M
GGT
PIL
G
IV
LG
VT
LV
---
S
P
QLMNAYLL
G
QQLPEVW
-
DF
GMF
S
I
AKVG
Y
QAQ
VIP
A
L
LAG
L
A
L
GV
IE
TR
L
KRIV
P
DYLYLVVV
P
V
CS
L
IL
AVF
LA
H
A
LIGP
F
G
R
M
I
GDG
V
A
FAVRH
L
MTGS
F
APIGA
A
L
F
G
F
L
Y
APL
V
I
TGVH
QTTL
A
ID
L
QMI
--
QSM
G
GTP
V
W
PL
I
AL
S
NI
AQG
fig|444453.5.peg.4084
Escherichia coli O157:H7 str. EC4076 (1-353/473)
M
MSK
I
NQTDID
R
L
I
EL
VGG
R
GNI
A
T
VS
HC
I
TRLRF
V
L
N
Q
PANARPKE
I
E
QLP
M
V
K
G
C
FT
N
AG
Q
F
QVVIG
TN
V
GD
-
YYQ
A
LIAST
G
QAQV
-
D
KEQVKKAARQNMKWHE---
--
QL
I
SHFAE
IF
F
PL
L
P
AL
I
SG
GL
I
LG
FRN
V
I
GDLPMSNG
Q
T
LAQMYPSL
Q
T
I
----
Y
D
FL
WLI
G
E
A
I
F
F
Y
LP
V
G
I
CW
SA
VKK
M
GGT
PIL
G
IV
LG
VT
LV
---
S
P
QLMNAYLL
G
QQLPEVW
-
DF
GMF
S
I
AKVG
Y
QAQ
VIP
A
L
LAG
L
A
L
GV
IE
TR
L
KRIV
P
DYLYLVVV
P
V
CS
L
IL
AVF
LA
H
A
LIGP
F
G
R
M
I
GDG
V
A
FAVRH
L
MTGS
F
APIGA
A
L
F
G
F
L
Y
APL
V
I
TGVH
QTTL
A
ID
L
QMI
--
QSM
G
GTP
V
W
PL
I
AL
S
NI
AQG
fig|444452.5.peg.3973
Escherichia coli O157:H7 str. EC4113 (1-353/473)
M
MSK
I
NQTDID
R
L
I
EL
VGG
R
GNI
A
T
VS
HC
I
TRLRF
V
L
N
Q
PANARPKE
I
E
QLP
M
V
K
G
C
FT
N
AG
Q
F
QVVIG
TN
V
GD
-
YYQ
A
LIAST
G
QAQV
-
D
KEQVKKAARQNMKWHE---
--
QL
I
SHFAE
IF
F
PL
L
P
AL
I
SG
GL
I
LG
FRN
V
I
GDLPMSNG
Q
T
LAQMYPSL
Q
T
I
----
Y
D
FL
WLI
G
E
A
I
F
F
Y
LP
V
G
I
CW
SA
VKK
M
GGT
PIL
G
IV
LG
VT
LV
---
S
P
QLMNAYLL
G
QQLPEVW
-
DF
GMF
S
I
AKVG
Y
QAQ
VIP
A
L
LAG
L
A
L
GV
IE
TR
L
KRIV
P
DYLYLVVV
P
V
CS
L
IL
AVF
LA
H
A
LIGP
F
G
R
M
I
GDG
V
A
FAVRH
L
MTGS
F
APIGA
A
L
F
G
F
L
Y
APL
V
I
TGVH
QTTL
A
ID
L
QMI
--
QSM
G
GTP
V
W
PL
I
AL
S
NI
AQG
fig|444450.8.peg.5599
Escherichia coli O157:H7 str. EC4115 (1-353/473)
M
MSK
I
NQTDID
R
L
I
EL
VGG
R
GNI
A
T
VS
HC
I
TRLRF
V
L
N
Q
PANARPKE
I
E
QLP
M
V
K
G
C
FT
N
AG
Q
F
QVVIG
TN
V
GD
-
YYQ
A
LIAST
G
QAQV
-
D
KEQVKKAARQNMKWHE---
--
QL
I
SHFAE
IF
F
PL
L
P
AL
I
SG
GL
I
LG
FRN
V
I
GDLPMSNG
Q
T
LAQMYPSL
Q
T
I
----
Y
D
FL
WLI
G
E
A
I
F
F
Y
LP
V
G
I
CW
SA
VKK
M
GGT
PIL
G
IV
LG
VT
LV
---
S
P
QLMNAYLL
G
QQLPEVW
-
DF
GMF
S
I
AKVG
Y
QAQ
VIP
A
L
LAG
L
A
L
GV
IE
TR
L
KRIV
P
DYLYLVVV
P
V
CS
L
IL
AVF
LA
H
A
LIGP
F
G
R
M
I
GDG
V
A
FAVRH
L
MTGS
F
APIGA
A
L
F
G
F
L
Y
APL
V
I
TGVH
QTTL
A
ID
L
QMI
--
QSM
G
GTP
V
W
PL
I
AL
S
NI
AQG
fig|444451.5.peg.1695
Escherichia coli O157:H7 str. EC4196 (1-353/473)
M
MSK
I
NQTDID
R
L
I
EL
VGG
R
GNI
A
T
VS
HC
I
TRLRF
V
L
N
Q
PANARPKE
I
E
QLP
M
V
K
G
C
FT
N
AG
Q
F
QVVIG
TN
V
GD
-
YYQ
A
LIAST
G
QAQV
-
D
KEQVKKAARQNMKWHE---
--
QL
I
SHFAE
IF
F
PL
L
P
AL
I
SG
GL
I
LG
FRN
V
I
GDLPMSNG
Q
T
LAQMYPSL
Q
T
I
----
Y
D
FL
WLI
G
E
A
I
F
F
Y
LP
V
G
I
CW
SA
VKK
M
GGT
PIL
G
IV
LG
VT
LV
---
S
P
QLMNAYLL
G
QQLPEVW
-
DF
GMF
S
I
AKVG
Y
QAQ
VIP
A
L
LAG
L
A
L
GV
IE
TR
L
KRIV
P
DYLYLVVV
P
V
CS
L
IL
AVF
LA
H
A
LIGP
F
G
R
M
I
GDG
V
A
FAVRH
L
MTGS
F
APIGA
A
L
F
G
F
L
Y
APL
V
I
TGVH
QTTL
A
ID
L
QMI
--
QSM
G
GTP
V
W
PL
I
AL
S
NI
AQG
fig|444447.5.peg.2685
Escherichia coli O157:H7 str. EC4206 (1-353/473)
M
MSK
I
NQTDID
R
L
I
EL
VGG
R
GNI
A
T
VS
HC
I
TRLRF
V
L
N
Q
PANARPKE
I
E
QLP
M
V
K
G
C
FT
N
AG
Q
F
QVVIG
TN
V
GD
-
YYQ
A
LIAST
G
QAQV
-
D
KEQVKKAARQNMKWHE---
--
QL
I
SHFAE
IF
F
PL
L
P
AL
I
SG
GL
I
LG
FRN
V
I
GDLPMSNG
Q
T
LAQMYPSL
Q
T
I
----
Y
D
FL
WLI
G
E
A
I
F
F
Y
LP
V
G
I
CW
SA
VKK
M
GGT
PIL
G
IV
LG
VT
LV
---
S
P
QLMNAYLL
G
QQLPEVW
-
DF
GMF
S
I
AKVG
Y
QAQ
VIP
A
L
LAG
L
A
L
GV
IE
TR
L
KRIV
P
DYLYLVVV
P
V
CS
L
IL
AVF
LA
H
A
LIGP
F
G
R
M
I
GDG
V
A
FAVRH
L
MTGS
F
APIGA
A
L
F
G
F
L
Y
APL
V
I
TGVH
QTTL
A
ID
L
QMI
--
QSM
G
GTP
V
W
PL
I
AL
S
NI
AQG
fig|478004.5.peg.1617
Escherichia coli O157:H7 str. EC4401 (1-353/473)
M
MSK
I
NQTDID
R
L
I
EL
VGG
R
GNI
A
T
VS
HC
I
TRLRF
V
L
N
Q
PANARPKE
I
E
QLP
M
V
K
G
C
FT
N
AG
Q
F
QVVIG
TN
V
GD
-
YYQ
A
LIAST
G
QAQV
-
D
KEQVKKAARQNMKWHE---
--
QL
I
SHFAE
IF
F
PL
L
P
AL
I
SG
GL
I
LG
FRN
V
I
GDLPMSNG
Q
T
LAQMYPSL
Q
T
I
----
Y
D
FL
WLI
G
E
A
I
F
F
Y
LP
V
G
I
CW
SA
VKK
M
GGT
PIL
G
IV
LG
VT
LV
---
S
P
QLMNAYLL
G
QQLPEVW
-
DF
GMF
S
I
AKVG
Y
QAQ
VIP
A
L
LAG
L
A
L
GV
IE
TR
L
KRIV
P
DYLYLVVV
P
V
CS
L
IL
AVF
LA
H
A
LIGP
F
G
R
M
I
GDG
V
A
FAVRH
L
MTGS
F
APIGA
A
L
F
G
F
L
Y
APL
V
I
TGVH
QTTL
A
ID
L
QMI
--
QSM
G
GTP
V
W
PL
I
AL
S
NI
AQG
fig|478006.5.peg.1049
Escherichia coli O157:H7 str. EC4501 (1-353/473)
M
MSK
I
NQTDID
R
L
I
EL
VGG
R
GNI
A
T
VS
HC
I
TRLRF
V
L
N
Q
PANARPKE
I
E
QLP
M
V
K
G
C
FT
N
AG
Q
F
QVVIG
TN
V
GD
-
YYQ
A
LIAST
G
QAQV
-
D
KEQVKKAARQNMKWHE---
--
QL
I
SHFAE
IF
F
PL
L
P
AL
I
SG
GL
I
LG
FRN
V
I
GDLPMSNG
Q
T
LAQMYPSL
Q
T
I
----
Y
D
FL
WLI
G
E
A
I
F
F
Y
LP
V
G
I
CW
SA
VKK
M
GGT
PIL
G
IV
LG
VT
LV
---
S
P
QLMNAYLL
G
QQLPEVW
-
DF
GMF
S
I
AKVG
Y
QAQ
VIP
A
L
LAG
L
A
L
GV
IE
TR
L
KRIV
P
DYLYLVVV
P
V
CS
L
IL
AVF
LA
H
A
LIGP
F
G
R
M
I
GDG
V
A
FAVRH
L
MTGS
F
APIGA
A
L
F
G
F
L
Y
APL
V
I
TGVH
QTTL
A
ID
L
QMI
--
QSM
G
GTP
V
W
PL
I
AL
S
NI
AQG
fig|478007.5.peg.667
Escherichia coli O157:H7 str. EC508 (1-353/473)
M
MSK
I
NQTDID
R
L
I
EL
VGG
R
GNI
A
T
VS
HC
I
TRLRF
V
L
N
Q
PANARPKE
I
E
QLP
M
V
K
G
C
FT
N
AG
Q
F
QVVIG
TN
V
GD
-
YYQ
A
LIAST
G
QAQV
-
D
KEQVKKAARQNMKWHE---
--
QL
I
SHFAE
IF
F
PL
L
P
AL
I
SG
GL
I
LG
FRN
V
I
GDLPMSNG
Q
T
LAQMYPSL
Q
T
I
----
Y
D
FL
WLI
G
E
A
I
F
F
Y
LP
V
G
I
CW
SA
VKK
M
GGT
PIL
G
IV
LG
VT
LV
---
S
P
QLMNAYLL
G
QQLPEVW
-
DF
GMF
S
I
AKVG
Y
QAQ
VIP
A
L
LAG
L
A
L
GV
IE
TR
L
KRIV
P
DYLYLVVV
P
V
CS
L
IL
AVF
LA
H
A
LIGP
F
G
R
M
I
GDG
V
A
FAVRH
L
MTGS
F
APIGA
A
L
F
G
F
L
Y
APL
V
I
TGVH
QTTL
A
ID
L
QMI
--
QSM
G
GTP
V
W
PL
I
AL
S
NI
AQG
fig|478008.5.peg.270
Escherichia coli O157:H7 str. EC869 (1-353/473)
M
MSK
I
NQTDID
R
L
I
EL
VGG
R
GNI
A
T
VS
HC
I
TRLRF
V
L
N
Q
PANARPKE
I
E
QLP
M
V
K
G
C
FT
N
AG
Q
F
QVVIG
TN
V
GD
-
YYQ
A
LIAST
G
QAQV
-
D
KEQVKKAARQNMKWHE---
--
QL
I
SHFAE
IF
F
PL
L
P
AL
I
SG
GL
I
LG
FRN
V
I
GDLPMSNG
Q
T
LAQMYPSL
Q
T
I
----
Y
D
FL
WLI
G
E
A
I
F
F
Y
LP
V
G
I
CW
SA
VKK
M
GGT
PIL
G
IV
LG
VT
LV
---
S
P
QLMNAYLL
G
QQLPEVW
-
DF
GMF
S
I
AKVG
Y
QAQ
VIP
A
L
LAG
L
A
L
GV
IE
TR
L
KRIV
P
DYLYLVVV
P
V
CS
L
IL
AVF
LA
H
A
LIGP
F
G
R
M
I
GDG
V
A
FAVRH
L
MTGS
F
APIGA
A
L
F
G
F
L
Y
APL
V
I
TGVH
QTTL
A
ID
L
QMI
--
QSM
G
GTP
V
W
PL
I
AL
S
NI
AQG
fig|637388.3.peg.2481
Escherichia coli O157:H7 str. FRIK2000 (1-353/473)
M
MSK
I
NQTDID
R
L
I
EL
VGG
R
GNI
A
T
VS
HC
I
TRLRF
V
L
N
Q
PANARPKE
I
E
QLP
M
V
K
G
C
FT
N
AG
Q
F
QVVIG
TN
V
GD
-
YYQ
A
LIAST
G
QAQV
-
D
KEQVKKAARQNMKWHE---
--
QL
I
SHFAE
IF
F
PL
L
P
AL
I
SG
GL
I
LG
FRN
V
I
GDLPMSNG
Q
T
LAQMYPSL
Q
T
I
----
Y
D
FL
WLI
G
E
A
I
F
F
Y
LP
V
G
I
CW
SA
VKK
M
GGT
PIL
G
IV
LG
VT
LV
---
S
P
QLMNAYLL
G
QQLPEVW
-
DF
GMF
S
I
AKVG
Y
QAQ
VIP
A
L
LAG
L
A
L
GV
IE
TR
L
KRIV
P
DYLYLVVV
P
V
CS
L
IL
AVF
LA
H
A
LIGP
F
G
R
M
I
GDG
V
A
FAVRH
L
MTGS
F
APIGA
A
L
F
G
F
L
Y
APL
V
I
TGVH
QTTL
A
ID
L
QMI
--
QSM
G
GTP
V
W
PL
I
AL
S
NI
AQG
fig|570506.3.peg.1238
Escherichia coli O157:H7 str. FRIK966 (1-353/473)
M
MSK
I
NQTDID
R
L
I
EL
VGG
R
GNI
A
T
VS
HC
I
TRLRF
V
L
N
Q
PANARPKE
I
E
QLP
M
V
K
G
C
FT
N
AG
Q
F
QVVIG
TN
V
GD
-
YYQ
A
LIAST
G
QAQV
-
D
KEQVKKAARQNMKWHE---
--
QL
I
SHFAE
IF
F
PL
L
P
AL
I
SG
GL
I
LG
FRN
V
I
GDLPMSNG
Q
T
LAQMYPSL
Q
T
I
----
Y
D
FL
WLI
G
E
A
I
F
F
Y
LP
V
G
I
CW
SA
VKK
M
GGT
PIL
G
IV
LG
VT
LV
---
S
P
QLMNAYLL
G
QQLPEVW
-
DF
GMF
S
I
AKVG
Y
QAQ
VIP
A
L
LAG
L
A
L
GV
IE
TR
L
KRIV
P
DYLYLVVV
P
V
CS
L
IL
AVF
LA
H
A
LIGP
F
G
R
M
I
GDG
V
A
FAVRH
L
MTGS
F
APIGA
A
L
F
G
F
L
Y
APL
V
I
TGVH
QTTL
A
ID
L
QMI
--
QSM
G
GTP
V
W
PL
I
AL
S
NI
AQG
fig|386585.9.peg.5455
Escherichia coli O157:H7 str. Sakai (1-353/473)
M
MSK
I
NQTDID
R
L
I
EL
VGG
R
GNI
A
T
VS
HC
I
TRLRF
V
L
N
Q
PANARPKE
I
E
QLP
M
V
K
G
C
FT
N
AG
Q
F
QVVIG
TN
V
GD
-
YYQ
A
LIAST
G
QAQV
-
D
KEQVKKAARQNMKWHE---
--
QL
I
SHFAE
IF
F
PL
L
P
AL
I
SG
GL
I
LG
FRN
V
I
GDLPMSNG
Q
T
LAQMYPSL
Q
T
I
----
Y
D
FL
WLI
G
E
A
I
F
F
Y
LP
V
G
I
CW
SA
VKK
M
GGT
PIL
G
IV
LG
VT
LV
---
S
P
QLMNAYLL
G
QQLPEVW
-
DF
GMF
S
I
AKVG
Y
QAQ
VIP
A
L
LAG
L
A
L
GV
IE
TR
L
KRIV
P
DYLYLVVV
P
V
CS
L
IL
AVF
LA
H
A
LIGP
F
G
R
M
I
GDG
V
A
FAVRH
L
MTGS
F
APIGA
A
L
F
G
F
L
Y
APL
V
I
TGVH
QTTL
A
ID
L
QMI
--
QSM
G
GTP
V
W
PL
I
AL
S
NI
AQG
fig|544404.4.peg.5410
Escherichia coli O157:H7 str. TW14359 (1-353/473)
M
MSK
I
NQTDID
R
L
I
EL
VGG
R
GNI
A
T
VS
HC
I
TRLRF
V
L
N
Q
PANARPKE
I
E
QLP
M
V
K
G
C
FT
N
AG
Q
F
QVVIG
TN
V
GD
-
YYQ
A
LIAST
G
QAQV
-
D
KEQVKKAARQNMKWHE---
--
QL
I
SHFAE
IF
F
PL
L
P
AL
I
SG
GL
I
LG
FRN
V
I
GDLPMSNG
Q
T
LAQMYPSL
Q
T
I
----
Y
D
FL
WLI
G
E
A
I
F
F
Y
LP
V
G
I
CW
SA
VKK
M
GGT
PIL
G
IV
LG
VT
LV
---
S
P
QLMNAYLL
G
QQLPEVW
-
DF
GMF
S
I
AKVG
Y
QAQ
VIP
A
L
LAG
L
A
L
GV
IE
TR
L
KRIV
P
DYLYLVVV
P
V
CS
L
IL
AVF
LA
H
A
LIGP
F
G
R
M
I
GDG
V
A
FAVRH
L
MTGS
F
APIGA
A
L
F
G
F
L
Y
APL
V
I
TGVH
QTTL
A
ID
L
QMI
--
QSM
G
GTP
V
W
PL
I
AL
S
NI
AQG
fig|502346.5.peg.1414
Escherichia coli O157:H7 str. TW14588 (1-353/473)
M
MSK
I
NQTDID
R
L
I
EL
VGG
R
GNI
A
T
VS
HC
I
TRLRF
V
L
N
Q
PANARPKE
I
E
QLP
M
V
K
G
C
FT
N
AG
Q
F
QVVIG
TN
V
GD
-
YYQ
A
LIAST
G
QAQV
-
D
KEQVKKAARQNMKWHE---
--
QL
I
SHFAE
IF
F
PL
L
P
AL
I
SG
GL
I
LG
FRN
V
I
GDLPMSNG
Q
T
LAQMYPSL
Q
T
I
----
Y
D
FL
WLI
G
E
A
I
F
F
Y
LP
V
G
I
CW
SA
VKK
M
GGT
PIL
G
IV
LG
VT
LV
---
S
P
QLMNAYLL
G
QQLPEVW
-
DF
GMF
S
I
AKVG
Y
QAQ
VIP
A
L
LAG
L
A
L
GV
IE
TR
L
KRIV
P
DYLYLVVV
P
V
CS
L
IL
AVF
LA
H
A
LIGP
F
G
R
M
I
GDG
V
A
FAVRH
L
MTGS
F
APIGA
A
L
F
G
F
L
Y
APL
V
I
TGVH
QTTL
A
ID
L
QMI
--
QSM
G
GTP
V
W
PL
I
AL
S
NI
AQG
fig|685038.3.peg.4401
Escherichia coli O83:H1 str. NRG 857C (1-353/473)
M
MSK
I
NQTDID
R
L
I
EL
VGG
R
GNI
A
T
VS
HC
I
TRLRF
V
L
N
Q
PANARPKE
I
E
QLP
M
V
K
G
C
FT
N
AG
Q
F
QVVIG
TN
V
GD
-
YYQ
A
LIAST
G
QAQV
-
D
KEQVKKAARQNMKWHE---
--
QL
I
SHFAE
IF
F
PL
L
P
AL
I
SG
GL
I
LG
FRN
V
I
GDLPMSNG
Q
T
LAQMYPSL
Q
T
I
----
Y
D
FL
WLI
G
E
A
I
F
F
Y
LP
V
G
I
CW
SA
VKK
M
GGT
PIL
G
IV
LG
VT
LV
---
S
P
QLMNAYLL
G
QQLPEVW
-
DF
GMF
S
I
AKVG
Y
QAQ
VIP
A
L
LAG
L
A
L
GV
IE
TR
L
KRIV
P
DYLYLVVV
P
V
CS
L
IL
AVF
LA
H
A
LIGP
F
G
R
M
I
GDG
V
A
FAVRH
L
MTGS
F
APIGA
A
L
F
G
F
L
Y
APL
V
I
TGVH
QTTL
A
ID
L
QMI
--
QSM
G
GTP
V
W
PL
I
AL
S
NI
AQG
fig|585035.6.peg.4728
Escherichia coli S88 (1-353/473)
M
MSK
I
NQTDID
R
L
I
EL
VGG
R
GNI
A
T
VS
HC
I
TRLRF
V
L
N
Q
PANARPKE
I
E
QLP
M
V
K
G
C
FT
N
AG
Q
F
QVVIG
TN
V
GD
-
YYQ
A
LIAST
G
QAQV
-
D
KEQVKKAARQNMKWHE---
--
QL
I
SHFAE
IF
F
PL
L
P
AL
I
SG
GL
I
LG
FRN
V
I
GDLPMSNG
Q
T
LAQMYPSL
Q
T
I
----
Y
D
FL
WLI
G
E
A
I
F
F
Y
LP
V
G
I
CW
SA
VKK
M
GGT
PIL
G
IV
LG
VT
LV
---
S
P
QLMNAYLL
G
QQLPEVW
-
DF
GMF
S
I
AKVG
Y
QAQ
VIP
A
L
LAG
L
A
L
GV
IE
TR
L
KRIV
P
DYLYLVVV
P
V
CS
L
IL
AVF
LA
H
A
LIGP
F
G
R
M
I
GDG
V
A
FAVRH
L
MTGS
F
APIGA
A
L
F
G
F
L
Y
APL
V
I
TGVH
QTTL
A
ID
L
QMI
--
QSM
G
GTP
V
W
PL
I
AL
S
NI
AQG
fig|409438.11.peg.4728
Escherichia coli SE11 (1-353/473)
M
MSK
I
NQTDID
R
L
I
EL
VGG
R
GNI
A
T
VS
HC
I
TRLRF
V
L
N
Q
PANARPKE
I
E
QLP
M
V
K
G
C
FT
N
AG
Q
F
QVVIG
TN
V
GD
-
YYQ
A
LIAST
G
QAQV
-
D
KEQVKKAARQNMKWHE---
--
QL
I
SHFAE
IF
F
PL
L
P
AL
I
SG
GL
I
LG
FRN
V
I
GDLPMSNG
Q
T
LAQMYPSL
Q
T
I
----
Y
D
FL
WLI
G
E
A
I
F
F
Y
LP
V
G
I
CW
SA
VKK
M
GGT
PIL
G
IV
LG
VT
LV
---
S
P
QLMNAYLL
G
QQLPEVW
-
DF
GMF
S
I
AKVG
Y
QAQ
VIP
A
L
LAG
L
A
L
GV
IE
TR
L
KRIV
P
DYLYLVVV
P
V
CS
L
IL
AVF
LA
H
A
LIGP
F
G
R
M
I
GDG
V
A
FAVRH
L
MTGS
F
APIGA
A
L
F
G
F
L
Y
APL
V
I
TGVH
QTTL
A
ID
L
QMI
--
QSM
G
GTP
V
W
PL
I
AL
S
NI
AQG
fig|656437.3.peg.4761
Escherichia coli TA143 (1-353/473)
M
MSK
I
NQTDID
R
L
I
EL
VGG
R
GNI
A
T
VS
HC
I
TRLRF
V
L
N
Q
PANARPKE
I
E
QLP
M
V
K
G
C
FT
N
AG
Q
F
QVVIG
TN
V
GD
-
YYQ
A
LIAST
G
QAQV
-
D
KEQVKKAARQNMKWHE---
--
QL
I
SHFAE
IF
F
PL
L
P
AL
I
SG
GL
I
LG
FRN
V
I
GDLPMSNG
Q
T
LAQMYPSL
Q
T
I
----
Y
D
FL
WLI
G
E
A
I
F
F
Y
LP
V
G
I
CW
SA
VKK
M
GGT
PIL
G
IV
LG
VT
LV
---
S
P
QLMNAYLL
G
QQLPEVW
-
DF
GMF
S
I
AKVG
Y
QAQ
VIP
A
L
LAG
L
A
L
GV
IE
TR
L
KRIV
P
DYLYLVVV
P
V
CS
L
IL
AVF
LA
H
A
LIGP
F
G
R
M
I
GDG
V
A
FAVRH
L
MTGS
F
APIGA
A
L
F
G
F
L
Y
APL
V
I
TGVH
QTTL
A
ID
L
QMI
--
QSM
G
GTP
V
W
PL
I
AL
S
NI
AQG
fig|656443.3.peg.5277
Escherichia coli TA271 (1-353/473)
M
MSK
I
NQTDID
R
L
I
EL
VGG
R
GNI
A
T
VS
HC
I
TRLRF
V
L
N
Q
PANARPKE
I
E
QLP
M
V
K
G
C
FT
N
AG
Q
F
QVVIG
TN
V
GD
-
YYQ
A
LIAST
G
QAQV
-
D
KEQVKKAARQNMKWHE---
--
QL
I
SHFAE
IF
F
PL
L
P
AL
I
SG
GL
I
LG
FRN
V
I
GDLPMSNG
Q
T
LAQMYPSL
Q
T
I
----
Y
D
FL
WLI
G
E
A
I
F
F
Y
LP
V
G
I
CW
SA
VKK
M
GGT
PIL
G
IV
LG
VT
LV
---
S
P
QLMNAYLL
G
QQLPEVW
-
DF
GMF
S
I
AKVG
Y
QAQ
VIP
A
L
LAG
L
A
L
GV
IE
TR
L
KRIV
P
DYLYLVVV
P
V
CS
L
IL
AVF
LA
H
A
LIGP
F
G
R
M
I
GDG
V
A
FAVRH
L
MTGS
F
APIGA
A
L
F
G
F
L
Y
APL
V
I
TGVH
QTTL
A
ID
L
QMI
--
QSM
G
GTP
V
W
PL
I
AL
S
NI
AQG
fig|216593.1.peg.3744
Escherichia coli E2348/69 (1-353/473)
M
MSK
I
NQTDID
R
L
I
EL
VGG
R
GNI
A
T
VS
HC
I
TRLRF
V
L
N
Q
PANARPKE
I
E
QLP
M
V
K
G
C
FT
N
AG
Q
F
QVVIG
TN
V
GD
-
YYQ
A
LIAST
G
QAQV
-
D
KEQVKKAARQNMKWHE---
--
QL
I
SHFAE
IF
F
PL
L
P
AL
I
SG
GL
I
LG
FRN
V
I
GDLPMSNG
Q
T
LAQMYPSL
Q
T
I
----
Y
D
FL
WLI
G
E
A
I
F
F
Y
LP
V
G
I
CW
SA
VKK
M
GGT
PIL
G
IV
LG
VT
LV
---
S
P
QLMNAYLL
G
QQLPEVW
-
DF
GMF
S
I
AKVG
Y
QAQ
VIP
A
L
LAG
L
A
L
GV
IE
TR
L
KRIV
P
DYLYLVVV
P
V
CS
L
IL
AVF
LA
H
A
LIGP
F
G
R
M
I
GDG
V
A
FAVRH
L
MTGS
F
APIGA
A
L
F
G
F
L
Y
APL
V
I
TGVH
QTTL
A
ID
L
QMI
--
QSM
G
GTP
V
W
PL
I
AL
S
NI
AQG
fig|585057.4.peg.4858
Escherichia coli IAI39 (1-353/473)
M
MSK
I
NQTDID
R
L
I
EL
VGG
R
GNI
A
T
VS
HC
I
TRLRF
V
L
N
Q
PANARPKE
I
E
QLP
M
V
K
G
C
FT
N
AG
Q
F
QVVIG
TN
V
GD
-
YYQ
A
LIAST
G
QAQV
-
D
KEQVKKAARQNMKWHE---
--
QL
I
SHFAE
IF
F
PL
L
P
AL
I
SG
GL
I
LG
FRN
V
I
GDLPMSNG
Q
T
LAQMYPSL
Q
T
I
----
Y
D
FL
WLI
G
E
A
I
F
F
Y
LP
V
G
I
CW
SA
VKK
M
GGT
PIL
G
IV
LG
VT
LV
---
S
P
QLMNAYLL
G
QQLPEVW
-
DF
GMF
S
I
AKVG
Y
QAQ
VIP
A
L
LAG
L
A
L
GV
IE
TR
L
KRIV
P
DYLYLVVV
P
V
CS
L
IL
AVF
LA
H
A
LIGP
F
G
R
M
I
GDG
V
A
FAVRH
L
LTGS
F
APIGA
A
L
F
G
F
L
Y
APL
V
I
TGVH
QTTL
A
ID
L
QMI
--
QSM
G
GTP
V
W
PL
I
AL
S
NI
AQG
fig|585057.6.peg.4866
Escherichia coli IAI39 (1-353/473)
M
MSK
I
NQTDID
R
L
I
EL
VGG
R
GNI
A
T
VS
HC
I
TRLRF
V
L
N
Q
PANARPKE
I
E
QLP
M
V
K
G
C
FT
N
AG
Q
F
QVVIG
TN
V
GD
-
YYQ
A
LIAST
G
QAQV
-
D
KEQVKKAARQNMKWHE---
--
QL
I
SHFAE
IF
F
PL
L
P
AL
I
SG
GL
I
LG
FRN
V
I
GDLPMSNG
Q
T
LAQMYPSL
Q
T
I
----
Y
D
FL
WLI
G
E
A
I
F
F
Y
LP
V
G
I
CW
SA
VKK
M
GGT
PIL
G
IV
LG
VT
LV
---
S
P
QLMNAYLL
G
QQLPEVW
-
DF
GMF
S
I
AKVG
Y
QAQ
VIP
A
L
LAG
L
A
L
GV
IE
TR
L
KRIV
P
DYLYLVVV
P
V
CS
L
IL
AVF
LA
H
A
LIGP
F
G
R
M
I
GDG
V
A
FAVRH
L
LTGS
F
APIGA
A
L
F
G
F
L
Y
APL
V
I
TGVH
QTTL
A
ID
L
QMI
--
QSM
G
GTP
V
W
PL
I
AL
S
NI
AQG
fig|679204.3.peg.26
Escherichia coli MS 145-7 (1-353/473)
M
MSK
I
NQTDID
R
L
I
EL
VGG
R
GNI
A
T
VS
HC
I
TRLRF
V
L
N
Q
PANARPKE
I
E
QLP
M
V
K
G
C
FT
N
AG
Q
F
QVVIG
TN
V
GD
-
YYQ
A
LIAST
G
QAQV
-
D
KEQVKKAARQNMKWHE---
--
QL
I
SHFAE
IF
F
PL
L
P
AL
I
SG
GL
I
LG
FRN
V
I
GDLPMSNG
Q
T
LAQMYPSL
Q
T
I
----
Y
D
FL
WLI
G
E
A
I
F
F
Y
LP
V
G
I
CW
SA
VKK
M
GGT
PIL
G
IV
LG
VT
LV
---
S
P
QLMNAYLL
G
QQLPEVW
-
DF
GMF
S
I
AKVG
Y
QAQ
VIP
A
L
LAG
L
A
L
GV
IE
TR
L
KRIV
P
DYLYLVVV
P
V
CS
L
IL
TVF
LA
H
A
LIGP
F
G
R
M
I
GDG
V
A
FAVRH
L
MTGS
F
APIGA
A
L
F
G
F
L
Y
APL
V
I
TGVH
QTTL
A
ID
L
QMI
--
QSM
G
GTP
V
W
PL
I
AL
S
NI
AQG
fig|481805.3.peg.4051
Escherichia coli ATCC 8739 (1-353/473)
M
MSK
I
NQTDID
R
L
I
EL
VGG
R
GNI
A
T
VS
HC
I
TRLRF
V
L
N
Q
PANARPKE
I
E
QLP
M
V
K
G
C
FT
N
AG
Q
F
QVVIG
TN
V
GD
-
YYQ
A
LIAST
G
QAQV
-
D
KEQVKKAARQNIKWHE---
--
QL
I
SHFAE
IF
F
PL
L
P
AL
I
SG
GL
I
LG
FRN
V
I
GDLPMSNG
Q
T
LAQMYPSL
Q
T
I
----
Y
D
FL
WLI
G
E
A
I
F
F
Y
LP
V
G
I
CW
SA
VKK
M
GGT
PIL
G
IV
LG
VT
LV
---
S
P
QLMNAYLL
G
QQLPEVW
-
DF
GMF
S
I
AKVG
Y
QAQ
VIP
A
L
LAG
L
A
L
GV
IE
TR
L
KRIV
P
DYLYLVVV
P
V
CS
L
IL
AVF
LA
H
A
LIGP
F
G
R
M
I
GDG
V
A
FAVRH
L
MTGS
F
APIGA
A
L
F
G
F
L
Y
APL
V
I
TGVH
QTTL
A
ID
L
QMI
--
QSM
G
GTP
V
W
PL
I
AL
S
NI
AQG
fig|481805.6.peg.4034
Escherichia coli ATCC 8739 (1-353/473)
M
MSK
I
NQTDID
R
L
I
EL
VGG
R
GNI
A
T
VS
HC
I
TRLRF
V
L
N
Q
PANARPKE
I
E
QLP
M
V
K
G
C
FT
N
AG
Q
F
QVVIG
TN
V
GD
-
YYQ
A
LIAST
G
QAQV
-
D
KEQVKKAARQNIKWHE---
--
QL
I
SHFAE
IF
F
PL
L
P
AL
I
SG
GL
I
LG
FRN
V
I
GDLPMSNG
Q
T
LAQMYPSL
Q
T
I
----
Y
D
FL
WLI
G
E
A
I
F
F
Y
LP
V
G
I
CW
SA
VKK
M
GGT
PIL
G
IV
LG
VT
LV
---
S
P
QLMNAYLL
G
QQLPEVW
-
DF
GMF
S
I
AKVG
Y
QAQ
VIP
A
L
LAG
L
A
L
GV
IE
TR
L
KRIV
P
DYLYLVVV
P
V
CS
L
IL
AVF
LA
H
A
LIGP
F
G
R
M
I
GDG
V
A
FAVRH
L
MTGS
F
APIGA
A
L
F
G
F
L
Y
APL
V
I
TGVH
QTTL
A
ID
L
QMI
--
QSM
G
GTP
V
W
PL
I
AL
S
NI
AQG
fig|656440.3.peg.4822
Escherichia coli TA206 (1-353/473)
M
MSK
I
NQTDID
R
L
I
EL
VGG
R
GNI
A
T
VS
HC
I
TRLRF
V
L
N
Q
PANARPKE
I
E
QLP
M
V
K
G
C
FT
N
AG
Q
F
QVVIG
TN
V
GD
-
YYQ
A
LIAST
G
QAQV
-
D
KEQVKKAARQNMKWHE---
--
QL
I
SHFAE
IF
F
PL
L
P
AL
I
SG
GL
I
LG
FRN
V
I
GDLPMSNG
Q
T
LAQMYPSL
Q
T
I
----
Y
D
FL
WLI
G
E
A
I
F
F
Y
LP
V
G
I
CW
SA
VKK
M
GGT
PIL
G
IV
LG
VT
LV
---
S
P
QLMNAYLL
G
QQLPEVW
-
DF
GIF
S
I
AKVG
Y
QAQ
VIP
A
L
LAG
L
A
L
GV
IE
TR
L
KRIV
P
DYLYLVVV
P
V
CS
L
IL
AVF
LA
H
A
LIGP
F
G
R
M
I
GDG
V
A
FAVRH
L
MTGS
F
APIGA
A
L
F
G
F
L
Y
APL
V
I
TGVH
QTTL
A
ID
L
QMI
--
QSM
G
GTP
V
W
PL
I
AL
S
NI
AQG
fig|405955.13.peg.4822
Escherichia coli APEC O1 (1-353/473)
M
MSK
I
NQTDID
R
L
I
EL
VGG
R
GNI
A
T
VS
HC
I
TRLRF
V
L
N
Q
PANARPKE
I
E
QLP
M
V
K
G
C
FT
N
AG
Q
F
QVVIG
TN
V
GD
-
YYQ
A
LIAST
G
QAQV
-
D
KEQVKKAARQNMKWHE---
--
QL
I
SHFAE
IF
F
PL
L
P
AL
I
SG
GL
I
LG
FRN
V
I
GDLPMSNG
Q
T
LAQMYPSL
Q
T
I
----
Y
D
FL
WLI
G
E
A
I
F
F
Y
LP
V
G
I
CW
SA
VKK
M
GGT
PIL
G
IV
LG
VT
LV
---
S
P
QLMNAYLL
G
QQLPEVW
-
N
F
GMF
S
I
AKVG
Y
QAQ
VIP
A
L
LAG
L
A
L
GV
IE
TR
L
KRIV
P
DYLYLVVV
P
V
CS
L
IL
AVF
LA
H
A
LIGP
F
G
R
M
I
GDG
V
A
FAVRH
L
MTGS
F
APIGA
A
L
F
G
F
L
Y
APL
V
I
TGVH
QTTL
A
ID
L
QMI
--
QSM
G
GTP
V
W
PL
I
AL
S
NI
AQG
fig|405955.9.peg.4070
Escherichia coli APEC O1 (1-353/473)
M
MSK
I
NQTDID
R
L
I
EL
VGG
R
GNI
A
T
VS
HC
I
TRLRF
V
L
N
Q
PANARPKE
I
E
QLP
M
V
K
G
C
FT
N
AG
Q
F
QVVIG
TN
V
GD
-
YYQ
A
LIAST
G
QAQV
-
D
KEQVKKAARQNMKWHE---
--
QL
I
SHFAE
IF
F
PL
L
P
AL
I
SG
GL
I
LG
FRN
V
I
GDLPMSNG
Q
T
LAQMYPSL
Q
T
I
----
Y
D
FL
WLI
G
E
A
I
F
F
Y
LP
V
G
I
CW
SA
VKK
M
GGT
PIL
G
IV
LG
VT
LV
---
S
P
QLMNAYLL
G
QQLPEVW
-
N
F
GMF
S
I
AKVG
Y
QAQ
VIP
A
L
LAG
L
A
L
GV
IE
TR
L
KRIV
P
DYLYLVVV
P
V
CS
L
IL
AVF
LA
H
A
LIGP
F
G
R
M
I
GDG
V
A
FAVRH
L
MTGS
F
APIGA
A
L
F
G
F
L
Y
APL
V
I
TGVH
QTTL
A
ID
L
QMI
--
QSM
G
GTP
V
W
PL
I
AL
S
NI
AQG
fig|714962.3.peg.4785
Escherichia coli IHE3034 (1-353/473)
M
MSK
I
NQTDID
R
L
I
EL
VGG
R
GNI
A
T
VS
HC
I
TRLRF
V
L
N
Q
PANARPKE
I
E
QLP
M
V
K
G
C
FT
N
AG
Q
F
QVVIG
TN
V
GD
-
YYQ
A
LIAST
G
QAQV
-
D
KEQVKKAARQNMKWHE---
--
QL
I
SHFAE
IF
F
PL
L
P
AL
I
SG
GL
I
LG
FRN
V
I
GDLPMSNG
Q
T
LAQMYPSL
Q
T
I
----
Y
D
FL
WLI
G
E
A
I
F
F
Y
LP
V
G
I
CW
SA
VKK
M
GGT
PIL
G
IV
LG
VT
LV
---
S
P
QLMNAYLL
G
QQLPEVW
-
N
F
GMF
S
I
AKVG
Y
QAQ
VIP
A
L
LAG
L
A
L
GV
IE
TR
L
KRIV
P
DYLYLVVV
P
V
CS
L
IL
AVF
LA
H
A
LIGP
F
G
R
M
I
GDG
V
A
FAVRH
L
MTGS
F
APIGA
A
L
F
G
F
L
Y
APL
V
I
TGVH
QTTL
A
ID
L
QMI
--
QSM
G
GTP
V
W
PL
I
AL
S
NI
AQG
fig|749531.3.peg.3657
Escherichia coli MS 69-1 (1-353/473)
M
MSK
I
NQTDID
R
L
I
EL
VGG
R
GNI
A
T
VS
HC
I
TRLRF
V
L
N
Q
PANARPKE
I
E
QLP
M
V
K
G
C
FT
N
AG
Q
F
QVVIG
TN
V
GD
-
YYQ
A
LIAST
G
QAQV
-
D
KEQVKKAARQNMKWHE---
--
QL
I
SHFAE
IF
F
PL
L
P
AL
I
SG
GL
I
LG
FRN
V
I
GDLPMSNG
Q
T
LAQMYPSL
Q
T
I
----
Y
D
FL
WLI
G
E
A
I
F
F
Y
LP
V
G
I
CW
SA
VKK
M
GGT
PIL
G
IV
LG
VT
LV
---
S
P
QLMNAYLL
G
QQLPEVW
-
DF
GMF
S
I
AKVG
Y
QAQ
VIP
A
L
LAG
L
A
L
GV
IE
TR
L
KRIV
P
DYLYLVVV
P
V
CS
L
IL
AVF
LA
H
A
LIGP
F
G
R
M
I
GNG
V
A
FAVRH
L
MTGS
F
APIGA
A
L
F
G
F
L
Y
APL
V
I
TGVH
QTTL
A
ID
L
QMI
--
QSM
G
GTP
V
W
PL
I
AL
S
NI
AQG
fig|869729.3.peg.4607
Escherichia coli UM146 (1-353/473)
M
MSK
I
NQTDID
R
L
I
EL
VGG
R
GNI
A
T
VS
HC
I
TRLRF
V
L
N
Q
PANARPKE
I
E
QLP
M
V
K
G
C
FT
N
AG
Q
F
QVVIG
TN
V
GD
-
YYQ
A
LIAST
G
QAQV
-
D
KEQVKKAARQNMKWHE---
--
QL
I
SHFAE
IF
F
PL
L
P
AL
I
SG
GL
I
LG
FRN
V
I
GDLPMSNG
Q
T
LAQMYPSL
Q
T
I
----
Y
D
FL
WLI
G
E
A
I
F
F
Y
LP
V
G
I
CW
SA
VKK
M
GGT
PIL
G
IV
LG
VT
LV
---
S
P
QLMNAYLL
G
QQLPEVW
-
N
F
GMF
S
I
AKVG
Y
QAQ
VIP
A
L
LAG
L
A
L
GV
IE
TR
L
KRIV
P
DYLYLVVV
P
V
CS
L
IL
AVF
LA
H
A
LIGP
F
G
R
M
I
GDG
V
A
FAVRH
L
MTGS
F
APIGA
A
L
F
G
F
L
Y
APL
V
I
TGVH
QTTL
A
ID
L
QMI
--
QSM
G
GTP
V
W
PL
I
AL
S
NI
AQG
fig|364106.7.peg.4720
Escherichia coli UTI89 (1-353/473)
M
MSK
I
NQTDID
R
L
I
EL
VGG
R
GNI
A
T
VS
HC
I
TRLRF
V
L
N
Q
PANARPKE
I
E
QLP
M
V
K
G
C
FT
N
AG
Q
F
QVVIG
TN
V
GD
-
YYQ
A
LIAST
G
QAQV
-
D
KEQVKKAARQNMKWHE---
--
QL
I
SHFAE
IF
F
PL
L
P
AL
I
SG
GL
I
LG
FRN
V
I
GDLPMSNG
Q
T
LAQMYPSL
Q
T
I
----
Y
D
FL
WLI
G
E
A
I
F
F
Y
LP
V
G
I
CW
SA
VKK
M
GGT
PIL
G
IV
LG
VT
LV
---
S
P
QLMNAYLL
G
QQLPEVW
-
N
F
GMF
S
I
AKVG
Y
QAQ
VIP
A
L
LAG
L
A
L
GV
IE
TR
L
KRIV
P
DYLYLVVV
P
V
CS
L
IL
AVF
LA
H
A
LIGP
F
G
R
M
I
GDG
V
A
FAVRH
L
MTGS
F
APIGA
A
L
F
G
F
L
Y
APL
V
I
TGVH
QTTL
A
ID
L
QMI
--
QSM
G
GTP
V
W
PL
I
AL
S
NI
AQG
fig|364106.8.peg.4720
Escherichia coli UTI89 (1-353/473)
M
MSK
I
NQTDID
R
L
I
EL
VGG
R
GNI
A
T
VS
HC
I
TRLRF
V
L
N
Q
PANARPKE
I
E
QLP
M
V
K
G
C
FT
N
AG
Q
F
QVVIG
TN
V
GD
-
YYQ
A
LIAST
G
QAQV
-
D
KEQVKKAARQNMKWHE---
--
QL
I
SHFAE
IF
F
PL
L
P
AL
I
SG
GL
I
LG
FRN
V
I
GDLPMSNG
Q
T
LAQMYPSL
Q
T
I
----
Y
D
FL
WLI
G
E
A
I
F
F
Y
LP
V
G
I
CW
SA
VKK
M
GGT
PIL
G
IV
LG
VT
LV
---
S
P
QLMNAYLL
G
QQLPEVW
-
N
F
GMF
S
I
AKVG
Y
QAQ
VIP
A
L
LAG
L
A
L
GV
IE
TR
L
KRIV
P
DYLYLVVV
P
V
CS
L
IL
AVF
LA
H
A
LIGP
F
G
R
M
I
GDG
V
A
FAVRH
L
MTGS
F
APIGA
A
L
F
G
F
L
Y
APL
V
I
TGVH
QTTL
A
ID
L
QMI
--
QSM
G
GTP
V
W
PL
I
AL
S
NI
AQG
fig|701177.3.peg.5074
Escherichia coli O55:H7 str. CB9615 (1-353/473)
M
MSK
I
NQTDID
R
L
I
EL
VGG
R
GNI
A
T
VS
HC
I
TRLRF
V
L
N
Q
PANARPKE
I
E
QLP
M
V
K
G
C
FT
N
AG
Q
F
QVVIG
TN
V
GD
-
YYQ
A
LIAST
G
QAQV
-
D
KEQVKKAARQNMKWHE---
--
QL
I
SHFAE
IF
F
PL
L
P
AL
I
SG
GL
I
LG
FRN
V
I
GDLPMSNG
Q
T
LAQMYPSL
Q
T
I
----
Y
D
FL
WLI
G
E
A
I
F
F
Y
LP
V
G
I
CW
SA
VKK
M
GGT
PIL
G
IV
LG
VT
LV
---
S
P
QLMNAYLL
G
QQLPEVW
-
DF
GMF
S
I
AKVG
Y
QAQ
VIP
A
L
LAG
L
A
L
GV
IE
TR
L
KRIV
P
DYLYLVVV
P
V
CS
L
IL
AVF
LA
H
A
LI
A
P
F
G
R
M
I
GDG
V
A
FAVRH
L
MTGS
F
APIGA
A
L
F
G
F
L
Y
APL
V
I
TGVH
QTTL
A
ID
L
QMI
--
QSM
G
GTP
V
W
PL
I
AL
S
NI
AQG
fig|439855.10.peg.4825
Escherichia coli SMS-3-5 (1-352/472)
MSK
I
NQTDID
R
L
I
EL
VGG
R
GNI
A
T
VS
HC
I
TRLRF
V
L
N
Q
PANARPKE
I
E
QLP
M
V
K
G
C
FT
N
AG
Q
F
QVVIG
TN
V
GD
-
YYQ
A
LIAST
G
QAQV
-
D
KEQVKKAARQNMKWHE---
--
QL
I
SHFAE
IF
F
PL
L
P
AL
I
SG
GL
I
LG
FRN
V
I
GDLPMSNG
Q
T
LAQMYPSL
Q
T
I
----
Y
D
FL
WLI
G
E
A
I
F
F
Y
LP
V
G
I
CW
SA
VKK
M
GGT
PIL
G
IV
LG
VT
LV
---
S
P
QLMNAYLL
G
QQLPEVW
-
DF
GMF
S
I
AKVG
Y
QAQ
VIP
A
L
LAG
L
A
L
GV
IE
TR
L
KRIV
P
DYLYLVVV
P
V
CS
L
IL
AVF
LA
H
A
LIGP
F
G
R
M
I
GDG
V
A
FAVRH
L
MTGS
F
APIGA
A
L
F
G
F
L
Y
APL
V
I
TGVH
QTTL
A
ID
L
QMI
--
QSM
G
GTP
V
W
PL
I
AL
S
NI
AQG
fig|562.376.peg.522
Escherichia coli WV_060327 (1-353/473)
M
MSK
I
NQTDID
R
L
I
EL
VGG
R
GNI
A
T
VS
HC
I
TRLRF
V
L
N
Q
PANARPKE
I
E
QLP
M
V
K
G
C
FT
N
AG
Q
F
QVVIG
TN
V
GD
-
YYQ
A
LIAST
G
QAQV
-
D
KEQVKKAARQNMKWHE---
--
QL
I
SHFAE
IF
F
PL
L
P
AL
I
SG
GL
I
LG
FRN
V
I
GDLPMSNG
Q
T
LAQMYPSL
Q
T
I
----
Y
D
FL
WLI
G
E
A
I
F
F
Y
LP
V
G
I
CW
SA
VKK
M
GGT
PIL
G
IV
LG
VT
LV
---
S
P
QLMNAYLL
G
QQLPEVW
-
N
F
GMF
S
I
AKVG
Y
QAQ
VIP
A
L
LAG
L
A
L
GV
IE
TR
L
KRIV
P
DYLYLVVV
P
V
CS
L
IL
AVF
LA
H
A
LIGP
F
G
R
M
I
GDG
V
A
FAVRH
L
MTGS
F
APIGA
A
L
F
G
F
L
Y
APL
V
I
TGVH
QTTL
A
ID
L
QMI
--
QSM
G
GTP
V
W
PL
I
AL
S
NI
AQG
fig|431946.3.peg.4296
Escherichia coli SE15 (1-353/473)
M
MSK
I
NQTDID
R
L
I
EL
VGG
R
GNI
A
T
VS
HC
I
TRLRF
V
L
S
Q
PANARPKE
I
E
QLP
M
V
K
G
C
FT
N
AG
Q
F
QVVIG
TN
V
GD
-
YYQ
A
LIAST
G
QAQV
-
D
KEQVKKAARQNMKWHE---
--
QL
I
SHFAE
IF
F
PL
L
P
AL
I
SG
GL
I
LG
FRN
V
I
GDLPMSNG
Q
T
LAQMYPSL
Q
T
I
----
Y
D
FL
WLI
G
E
A
I
F
F
Y
LP
V
G
I
CW
SA
VKK
M
GGT
PIL
G
IV
LG
VT
LV
---
S
P
QLMNAYLL
G
QQLPEVW
-
DF
GMF
S
I
AKVG
Y
QAQ
VIP
A
L
LAG
L
A
L
GV
IE
TR
L
KRIV
P
DYLYLVVV
P
V
CS
L
IL
AVF
LA
H
A
LIGP
F
G
R
M
I
GDG
V
A
FAVRH
L
MTGS
F
APIGA
A
L
F
G
F
L
Y
APL
V
I
TGVH
QTTL
A
ID
L
QMI
--
QSM
G
GTP
V
W
PL
I
AL
S
NI
AQG
fig|656393.3.peg.472
Escherichia coli H299 (1-353/473)
M
MSK
I
NQTDID
R
L
I
EL
VGG
R
GNI
A
T
VS
HC
I
TRL
H
F
V
L
N
Q
PANARPKE
I
E
QLP
M
V
K
G
C
FT
N
AG
Q
F
QVVIG
TN
V
GD
-
YYQ
A
LIAST
G
QAQV
-
D
KEQVKKAARQNMKWHE---
--
QL
I
SHFAE
IF
F
PL
L
P
AL
I
SG
GL
I
LG
FRN
V
I
GDLPMSNG
Q
T
LAQMYPSL
Q
T
I
----
Y
D
FL
WLI
G
E
A
I
F
F
Y
LP
V
G
I
CW
SA
VKK
M
GGT
PIL
G
IV
LG
VT
LV
---
S
P
QLMNAYLL
G
QQLPEVW
-
DF
GMF
S
I
AKVG
Y
QAQ
VIP
A
L
LAG
L
A
L
GV
IE
TR
L
KRIV
P
DYLYLVVV
P
V
CS
L
IL
AVF
LA
H
A
LIGP
F
G
R
M
I
GDG
V
A
FAVRH
L
MTGS
F
APIGA
A
L
F
G
F
L
Y
APL
V
I
TGVH
QTTL
A
ID
L
QMI
--
QSM
G
GTP
V
W
PL
I
AL
S
NI
AQG
fig|6666666.5357.peg.822
Escherichia coli TY-2482 (1-353/473)
M
MSK
I
NQTDID
R
L
I
EL
VGG
R
GNI
A
T
VS
HC
I
TRLRF
V
L
N
Q
PANARPKE
I
E
QLP
M
V
K
G
C
FT
N
AG
Q
F
QVVIG
TN
V
GD
-
YYQ
A
LIAST
G
QAQV
-
D
KEQVKKAARQNMKWHE---
--
QL
I
SHFAE
IF
F
PL
L
P
AL
I
SG
GL
I
LG
FRN
V
I
GDLPMSNG
Q
T
LAQMYPSL
Q
T
I
----
Y
D
FL
WLI
G
E
A
I
F
F
Y
LP
V
G
I
CW
SA
VKK
W
GGT
PIL
G
IV
LG
VT
LV
---
S
P
QLMNAYLL
G
QQLPEVW
-
DF
GMF
S
I
AKVG
Y
QAQ
VIP
A
L
LAG
L
A
L
GV
IE
TR
L
KRIV
P
DYLYLVVV
P
V
CS
L
IL
AVF
LA
H
A
LIGP
F
G
R
M
I
GDG
V
A
FAVRH
L
MTGS
F
APIGA
A
L
F
G
F
L
Y
APL
V
I
TGVH
QTTL
A
ID
L
QMI
--
QSM
G
GTP
V
W
PL
I
AL
S
NI
AQG
fig|574521.7.peg.4673
Escherichia coli O127:H6 str. E2348/69 (1-352/472)
MSK
I
NQTDID
R
L
I
EL
VGG
R
GNI
A
T
VS
HC
I
TRLRF
V
L
N
Q
PANARPKE
I
E
QLP
M
V
K
G
C
FT
N
AG
Q
F
QVVIG
TN
V
GD
-
YYQ
A
LIAST
G
QAQV
-
D
KEQVKKAARQNMKWHE---
--
QL
I
SHFAE
IF
F
PL
L
P
AL
I
SG
GL
I
LG
FRN
V
I
GDLPMSNG
Q
T
LAQMYPSL
Q
T
I
----
Y
D
FL
WLI
G
E
A
I
F
F
Y
LP
V
G
I
CW
SA
VKK
M
GGT
PIL
G
IV
LG
VT
LV
---
S
P
QLMNAYLL
G
QQLPEVW
-
DF
GMF
S
I
AKVG
Y
QAQ
VIP
A
L
LAG
L
A
L
GV
IE
TR
L
KRIV
P
DYLYLVVV
P
V
CS
L
IL
AVF
LA
H
A
LIGP
F
G
R
M
I
GDG
V
A
FAVRH
L
MTGS
F
APIGA
A
L
F
G
F
L
Y
APL
V
I
TGVH
QTTL
A
ID
L
QMI
--
QSM
G
GTP
V
W
PL
I
AL
S
NI
AQG
fig|525281.3.peg.1624
Escherichia coli 83972 (1-353/473)
M
MSK
I
NQTDID
R
L
I
EM
VGG
R
GNI
A
T
VS
HC
I
TRLRF
V
L
N
Q
PANARPKE
I
E
QLP
M
V
K
G
C
FT
N
AG
Q
F
QVVIG
TN
V
GD
-
YYQ
A
LIAST
G
QAQV
-
D
KEQVKKAARQNMKWHE---
--
QL
I
SHFAE
IF
F
PL
L
P
AL
I
SG
GL
I
LG
FRN
V
I
GDLPMSNG
Q
T
LAQMYPSL
Q
T
I
----
Y
D
FL
WLI
G
E
A
I
F
F
Y
LP
V
G
I
CW
SA
VKK
M
GGT
PIL
G
IV
LG
VT
LV
---
S
P
QLMNAYLL
G
QQLPEVW
-
DF
GIF
S
I
AKVG
Y
QAQ
VIP
A
L
LAG
L
A
L
GV
IE
TR
L
KRIV
P
DYLYLVVV
P
V
CS
L
IL
AVF
LA
H
A
LIGP
F
G
R
M
I
GDG
V
A
FAVRH
L
MTGS
F
APIGA
A
L
F
G
F
L
Y
APL
V
I
TGVH
QTTL
A
ID
L
QMI
--
QSM
G
GTP
V
W
PL
I
AL
S
NI
AQG
fig|655817.3.peg.5000
Escherichia coli ABU 83972 (1-353/473)
M
MSK
I
NQTDID
R
L
I
EM
VGG
R
GNI
A
T
VS
HC
I
TRLRF
V
L
N
Q
PANARPKE
I
E
QLP
M
V
K
G
C
FT
N
AG
Q
F
QVVIG
TN
V
GD
-
YYQ
A
LIAST
G
QAQV
-
D
KEQVKKAARQNMKWHE---
--
QL
I
SHFAE
IF
F
PL
L
P
AL
I
SG
GL
I
LG
FRN
V
I
GDLPMSNG
Q
T
LAQMYPSL
Q
T
I
----
Y
D
FL
WLI
G
E
A
I
F
F
Y
LP
V
G
I
CW
SA
VKK
M
GGT
PIL
G
IV
LG
VT
LV
---
S
P
QLMNAYLL
G
QQLPEVW
-
DF
GIF
S
I
AKVG
Y
QAQ
VIP
A
L
LAG
L
A
L
GV
IE
TR
L
KRIV
P
DYLYLVVV
P
V
CS
L
IL
AVF
LA
H
A
LIGP
F
G
R
M
I
GDG
V
A
FAVRH
L
MTGS
F
APIGA
A
L
F
G
F
L
Y
APL
V
I
TGVH
QTTL
A
ID
L
QMI
--
QSM
G
GTP
V
W
PL
I
AL
S
NI
AQG
fig|199310.1.peg.5229
Escherichia coli CFT073 (1-353/473)
M
MSK
I
NQTDID
R
L
I
EM
VGG
R
GNI
A
T
VS
HC
I
TRLRF
V
L
N
Q
PANARPKE
I
E
QLP
M
V
K
G
C
FT
N
AG
Q
F
QVVIG
TN
V
GD
-
YYQ
A
LIAST
G
QAQV
-
D
KEQVKKAARQNMKWHE---
--
QL
I
SHFAE
IF
F
PL
L
P
AL
I
SG
GL
I
LG
FRN
V
I
GDLPMSNG
Q
T
LAQMYPSL
Q
T
I
----
Y
D
FL
WLI
G
E
A
I
F
F
Y
LP
V
G
I
CW
SA
VKK
M
GGT
PIL
G
IV
LG
VT
LV
---
S
P
QLMNAYLL
G
QQLPEVW
-
DF
GIF
S
I
AKVG
Y
QAQ
VIP
A
L
LAG
L
A
L
GV
IE
TR
L
KRIV
P
DYLYLVVV
P
V
CS
L
IL
AVF
LA
H
A
LIGP
F
G
R
M
I
GDG
V
A
FAVRH
L
MTGS
F
APIGA
A
L
F
G
F
L
Y
APL
V
I
TGVH
QTTL
A
ID
L
QMI
--
QSM
G
GTP
V
W
PL
I
AL
S
NI
AQG
fig|199310.4.peg.5001
Escherichia coli CFT073 (1-353/473)
M
MSK
I
NQTDID
R
L
I
EM
VGG
R
GNI
A
T
VS
HC
I
TRLRF
V
L
N
Q
PANARPKE
I
E
QLP
M
V
K
G
C
FT
N
AG
Q
F
QVVIG
TN
V
GD
-
YYQ
A
LIAST
G
QAQV
-
D
KEQVKKAARQNMKWHE---
--
QL
I
SHFAE
IF
F
PL
L
P
AL
I
SG
GL
I
LG
FRN
V
I
GDLPMSNG
Q
T
LAQMYPSL
Q
T
I
----
Y
D
FL
WLI
G
E
A
I
F
F
Y
LP
V
G
I
CW
SA
VKK
M
GGT
PIL
G
IV
LG
VT
LV
---
S
P
QLMNAYLL
G
QQLPEVW
-
DF
GIF
S
I
AKVG
Y
QAQ
VIP
A
L
LAG
L
A
L
GV
IE
TR
L
KRIV
P
DYLYLVVV
P
V
CS
L
IL
AVF
LA
H
A
LIGP
F
G
R
M
I
GDG
V
A
FAVRH
L
MTGS
F
APIGA
A
L
F
G
F
L
Y
APL
V
I
TGVH
QTTL
A
ID
L
QMI
--
QSM
G
GTP
V
W
PL
I
AL
S
NI
AQG
fig|749546.3.peg.2446
Escherichia coli MS 185-1 (1-353/473)
M
MSK
I
NQTDID
R
L
I
EM
VGG
R
GNI
A
T
VS
HC
I
TRLRF
V
L
N
Q
PANARPKE
I
E
QLP
M
V
K
G
C
FT
N
AG
Q
F
QVVIG
TN
V
GD
-
YYQ
A
LIAST
G
QAQV
-
D
KEQVKKAARQNMKWHE---
--
QL
I
SHFAE
IF
F
PL
L
P
AL
I
SG
GL
I
LG
FRN
V
I
GDLPMSNG
Q
T
LAQMYPSL
Q
T
I
----
Y
D
FL
WLI
G
E
A
I
F
F
Y
LP
V
G
I
CW
SA
VKK
M
GGT
PIL
G
IV
LG
VT
LV
---
S
P
QLMNAYLL
G
QQLPEVW
-
DF
GIF
S
I
AKVG
Y
QAQ
VIP
A
L
LAG
L
A
L
GV
IE
TR
L
KRIV
P
DYLYLVVV
P
V
CS
L
IL
AVF
LA
H
A
LIGP
F
G
R
M
I
GDG
V
A
FAVRH
L
MTGS
F
APIGA
A
L
F
G
F
L
Y
APL
V
I
TGVH
QTTL
A
ID
L
QMI
--
QSM
G
GTP
V
W
PL
I
AL
S
NI
AQG
fig|749528.3.peg.3426
Escherichia coli MS 45-1 (1-353/473)
M
MSK
I
NQTDID
R
L
I
EM
VGG
R
GNI
A
T
VS
HC
I
TRLRF
V
L
N
Q
PANARPKE
I
E
QLP
M
V
K
G
C
FT
N
AG
Q
F
QVVIG
TN
V
GD
-
YYQ
A
LIAST
G
QAQV
-
D
KEQVKKAARQNMKWHE---
--
QL
I
SHFAE
IF
F
PL
L
P
AL
I
SG
GL
I
LG
FRN
V
I
GDLPMSNG
Q
T
LAQMYPSL
Q
T
I
----
Y
D
FL
WLI
G
E
A
I
F
F
Y
LP
V
G
I
CW
SA
VKK
M
GGT
PIL
G
IV
LG
VT
LV
---
S
P
QLMNAYLL
G
QQLPEVW
-
DF
GIF
S
I
AKVG
Y
QAQ
VIP
A
L
LAG
L
A
L
GV
IE
TR
L
KRIV
P
DYLYLVVV
P
V
CS
L
IL
AVF
LA
H
A
LIGP
F
G
R
M
I
GDG
V
A
FAVRH
L
MTGS
F
APIGA
A
L
F
G
F
L
Y
APL
V
I
TGVH
QTTL
A
ID
L
QMI
--
QSM
G
GTP
V
W
PL
I
AL
S
NI
AQG
fig|413997.3.peg.4335
Escherichia coli B str. REL606 (1-353/473)
M
MSK
I
NQTDID
R
L
I
EL
VGG
R
GNI
A
T
VS
HC
I
TRLRF
V
L
N
Q
PANARPKE
I
E
QLP
M
V
K
G
C
FT
N
AG
Q
F
QVVIG
TN
V
GD
-
YYQ
A
LIAST
G
QAQV
-
D
KEQVKKAARQNMKWHE---
--
QL
I
SHFAE
IF
F
PL
L
P
AL
I
SG
GL
I
LG
FRN
V
I
GDLPMSNG
Q
T
LAQMYPSL
Q
T
I
----
Y
D
FL
WLI
G
E
A
I
F
F
Y
LP
V
G
I
CW
SA
VKK
M
GGT
PIL
G
IV
LG
VT
LV
---
S
P
QLMNAYLL
G
QQLPEVW
-
DF
GMF
S
I
AKVG
Y
QAQ
VIP
A
L
LAG
L
A
L
GV
IE
TR
L
KRIV
P
DYLYLVVV
P
V
CS
L
IL
AVF
LA
H
A
LIGP
F
G
R
M
I
GDG
V
A
FAVRH
L
MTGS
F
APIGA
A
L
F
G
F
L
Y
APL
V
I
TGVH
QTTL
A
ID
L
QMI
--
QSM
G
GTP
V
W
PL
I
AL
S
NI
AQG
fig|344601.3.peg.888
Escherichia coli B171 (1-353/473)
M
MSK
I
NQTDID
R
L
I
EL
VGG
R
GNI
A
T
VS
HC
I
TRLRF
V
L
N
Q
PANARPKE
I
E
QLP
M
V
K
G
C
FT
N
AG
Q
F
QVVIG
TN
V
GD
-
YYQ
A
LIAST
G
QAQV
-
D
KEQVKKAARQNMKWHE---
--
QL
I
SHFAE
IF
F
PL
L
P
AL
I
SG
GL
I
LG
FRN
V
I
GDLPMSNG
Q
T
LAQMYPSL
Q
T
I
----
Y
D
FL
WLI
G
E
A
I
F
F
Y
LP
V
G
I
CW
SA
VKK
M
GGT
PIL
G
IV
LG
VT
LV
---
S
P
QLMNAYLL
G
QQLPEVW
-
DF
GMF
S
I
AKVG
Y
QAQ
VIP
A
L
LAG
L
A
L
GV
IE
TR
L
KRIV
P
DYLYLVVV
P
V
CS
L
IL
AVF
LA
H
A
LIGP
F
G
R
M
I
GDG
V
A
FAVRH
L
MTGS
F
APIGA
A
L
F
G
F
L
Y
APL
V
I
TGVH
QTTL
A
ID
L
QMI
--
QSM
G
GTP
V
W
PL
I
AL
S
NI
AQG
fig|344601.5.peg.939
Escherichia coli B171 (1-353/473)
M
MSK
I
NQTDID
R
L
I
EL
VGG
R
GNI
A
T
VS
HC
I
TRLRF
V
L
N
Q
PANARPKE
I
E
QLP
M
V
K
G
C
FT
N
AG
Q
F
QVVIG
TN
V
GD
-
YYQ
A
LIAST
G
QAQV
-
D
KEQVKKAARQNMKWHE---
--
QL
I
SHFAE
IF
F
PL
L
P
AL
I
SG
GL
I
LG
FRN
V
I
GDLPMSNG
Q
T
LAQMYPSL
Q
T
I
----
Y
D
FL
WLI
G
E
A
I
F
F
Y
LP
V
G
I
CW
SA
VKK
M
GGT
PIL
G
IV
LG
VT
LV
---
S
P
QLMNAYLL
G
QQLPEVW
-
DF
GMF
S
I
AKVG
Y
QAQ
VIP
A
L
LAG
L
A
L
GV
IE
TR
L
KRIV
P
DYLYLVVV
P
V
CS
L
IL
AVF
LA
H
A
LIGP
F
G
R
M
I
GDG
V
A
FAVRH
L
MTGS
F
APIGA
A
L
F
G
F
L
Y
APL
V
I
TGVH
QTTL
A
ID
L
QMI
--
QSM
G
GTP
V
W
PL
I
AL
S
NI
AQG
fig|340184.3.peg.2336
Escherichia coli B7A (1-353/473)
M
MSK
I
NQTDID
R
L
I
EL
VGG
R
GNI
A
T
VS
HC
I
TRLRF
V
L
N
Q
PANARPKE
I
E
QLP
M
V
K
G
C
FT
N
AG
Q
F
QVVIG
TN
V
GD
-
YYQ
A
LIAST
G
QAQV
-
D
KEQVKKAARQNMKWHE---
--
QL
I
SHFAE
IF
F
PL
L
P
AL
I
SG
GL
I
LG
FRN
V
I
GDLPMSNG
Q
T
LAQMYPSL
Q
T
I
----
Y
D
FL
WLI
G
E
A
I
F
F
Y
LP
V
G
I
CW
SA
VKK
M
GGT
PIL
G
IV
LG
VT
LV
---
S
P
QLMNAYLL
G
QQLPEVW
-
DF
GMF
S
I
AKVG
Y
QAQ
VIP
A
L
LAG
L
A
L
GV
IE
TR
L
KRIV
P
DYLYLVVV
P
V
CS
L
IL
AVF
LA
H
A
LIGP
F
G
R
M
I
GDG
V
A
FAVRH
L
MTGS
F
APIGA
A
L
F
G
F
L
Y
APL
V
I
TGVH
QTTL
A
ID
L
QMI
--
QSM
G
GTP
V
W
PL
I
AL
S
NI
AQG
fig|340184.6.peg.2455
Escherichia coli B7A (1-353/473)
M
MSK
I
NQTDID
R
L
I
EL
VGG
R
GNI
A
T
VS
HC
I
TRLRF
V
L
N
Q
PANARPKE
I
E
QLP
M
V
K
G
C
FT
N
AG
Q
F
QVVIG
TN
V
GD
-
YYQ
A
LIAST
G
QAQV
-
D
KEQVKKAARQNMKWHE---
--
QL
I
SHFAE
IF
F
PL
L
P
AL
I
SG
GL
I
LG
FRN
V
I
GDLPMSNG
Q
T
LAQMYPSL
Q
T
I
----
Y
D
FL
WLI
G
E
A
I
F
F
Y
LP
V
G
I
CW
SA
VKK
M
GGT
PIL
G
IV
LG
VT
LV
---
S
P
QLMNAYLL
G
QQLPEVW
-
DF
GMF
S
I
AKVG
Y
QAQ
VIP
A
L
LAG
L
A
L
GV
IE
TR
L
KRIV
P
DYLYLVVV
P
V
CS
L
IL
AVF
LA
H
A
LIGP
F
G
R
M
I
GDG
V
A
FAVRH
L
MTGS
F
APIGA
A
L
F
G
F
L
Y
APL
V
I
TGVH
QTTL
A
ID
L
QMI
--
QSM
G
GTP
V
W
PL
I
AL
S
NI
AQG
fig|511693.5.peg.4357
Escherichia coli BL21 (1-353/473)
M
MSK
I
NQTDID
R
L
I
EL
VGG
R
GNI
A
T
VS
HC
I
TRLRF
V
L
N
Q
PANARPKE
I
E
QLP
M
V
K
G
C
FT
N
AG
Q
F
QVVIG
TN
V
GD
-
YYQ
A
LIAST
G
QAQV
-
D
KEQVKKAARQNMKWHE---
--
QL
I
SHFAE
IF
F
PL
L
P
AL
I
SG
GL
I
LG
FRN
V
I
GDLPMSNG
Q
T
LAQMYPSL
Q
T
I
----
Y
D
FL
WLI
G
E
A
I
F
F
Y
LP
V
G
I
CW
SA
VKK
M
GGT
PIL
G
IV
LG
VT
LV
---
S
P
QLMNAYLL
G
QQLPEVW
-
DF
GMF
S
I
AKVG
Y
QAQ
VIP
A
L
LAG
L
A
L
GV
IE
TR
L
KRIV
P
DYLYLVVV
P
V
CS
L
IL
AVF
LA
H
A
LIGP
F
G
R
M
I
GDG
V
A
FAVRH
L
MTGS
F
APIGA
A
L
F
G
F
L
Y
APL
V
I
TGVH
QTTL
A
ID
L
QMI
--
QSM
G
GTP
V
W
PL
I
AL
S
NI
AQG
fig|469008.4.peg.3934
Escherichia coli BL21(DE3) (1-353/473)
M
MSK
I
NQTDID
R
L
I
EL
VGG
R
GNI
A
T
VS
HC
I
TRLRF
V
L
N
Q
PANARPKE
I
E
QLP
M
V
K
G
C
FT
N
AG
Q
F
QVVIG
TN
V
GD
-
YYQ
A
LIAST
G
QAQV
-
D
KEQVKKAARQNMKWHE---
--
QL
I
SHFAE
IF
F
PL
L
P
AL
I
SG
GL
I
LG
FRN
V
I
GDLPMSNG
Q
T
LAQMYPSL
Q
T
I
----
Y
D
FL
WLI
G
E
A
I
F
F
Y
LP
V
G
I
CW
SA
VKK
M
GGT
PIL
G
IV
LG
VT
LV
---
S
P
QLMNAYLL
G
QQLPEVW
-
DF
GMF
S
I
AKVG
Y
QAQ
VIP
A
L
LAG
L
A
L
GV
IE
TR
L
KRIV
P
DYLYLVVV
P
V
CS
L
IL
AVF
LA
H
A
LIGP
F
G
R
M
I
GDG
V
A
FAVRH
L
MTGS
F
APIGA
A
L
F
G
F
L
Y
APL
V
I
TGVH
QTTL
A
ID
L
QMI
--
QSM
G
GTP
V
W
PL
I
AL
S
NI
AQG
fig|340185.3.peg.1993
Escherichia coli E22 (1-353/473)
M
MSK
I
NQTDID
R
L
I
EL
VGG
R
GNI
A
T
VS
HC
I
TRLRF
V
L
N
Q
PANARPKE
I
E
QLP
M
V
K
G
C
FT
N
AG
Q
F
QVVIG
TN
V
GD
-
YYQ
A
LIAST
G
QAQV
-
D
KEQVKKAARQNMKWHE---
--
QL
I
SHFAE
IF
F
PL
L
P
AL
I
SG
GL
I
LG
FRN
V
I
GDLPMSNG
Q
T
LAQMYPSL
Q
T
I
----
Y
D
FL
WLI
G
E
A
I
F
F
Y
LP
V
G
I
CW
SA
VKK
M
GGT
PIL
G
IV
LG
VT
LV
---
S
P
QLMNAYLL
G
QQLPEVW
-
DF
GMF
S
I
AKVG
Y
QAQ
VIP
A
L
LAG
L
A
L
GV
IE
TR
L
KRIV
P
DYLYLVVV
P
V
CS
L
IL
AVF
LA
H
A
LIGP
F
G
R
M
I
GDG
V
A
FAVRH
L
MTGS
F
APIGA
A
L
F
G
F
L
Y
APL
V
I
TGVH
QTTL
A
ID
L
QMI
--
QSM
G
GTP
V
W
PL
I
AL
S
NI
AQG
fig|340185.4.peg.2110
Escherichia coli E22 (1-353/473)
M
MSK
I
NQTDID
R
L
I
EL
VGG
R
GNI
A
T
VS
HC
I
TRLRF
V
L
N
Q
PANARPKE
I
E
QLP
M
V
K
G
C
FT
N
AG
Q
F
QVVIG
TN
V
GD
-
YYQ
A
LIAST
G
QAQV
-
D
KEQVKKAARQNMKWHE---
--
QL
I
SHFAE
IF
F
PL
L
P
AL
I
SG
GL
I
LG
FRN
V
I
GDLPMSNG
Q
T
LAQMYPSL
Q
T
I
----
Y
D
FL
WLI
G
E
A
I
F
F
Y
LP
V
G
I
CW
SA
VKK
M
GGT
PIL
G
IV
LG
VT
LV
---
S
P
QLMNAYLL
G
QQLPEVW
-
DF
GMF
S
I
AKVG
Y
QAQ
VIP
A
L
LAG
L
A
L
GV
IE
TR
L
KRIV
P
DYLYLVVV
P
V
CS
L
IL
AVF
LA
H
A
LIGP
F
G
R
M
I
GDG
V
A
FAVRH
L
MTGS
F
APIGA
A
L
F
G
F
L
Y
APL
V
I
TGVH
QTTL
A
ID
L
QMI
--
QSM
G
GTP
V
W
PL
I
AL
S
NI
AQG
fig|331111.12.peg.5010
Escherichia coli E24377A (1-353/473)
M
MSK
I
NQTDID
R
L
I
EL
VGG
R
GNI
A
T
VS
HC
I
TRLRF
V
L
N
Q
PANARPKE
I
E
QLP
M
V
K
G
C
FT
N
AG
Q
F
QVVIG
TN
V
GD
-
YYQ
A
LIAST
G
QAQV
-
D
KEQVKKAARQNMKWHE---
--
QL
I
SHFAE
IF
F
PL
L
P
AL
I
SG
GL
I
LG
FRN
V
I
GDLPMSNG
Q
T
LAQMYPSL
Q
T
I
----
Y
D
FL
WLI
G
E
A
I
F
F
Y
LP
V
G
I
CW
SA
VKK
M
GGT
PIL
G
IV
LG
VT
LV
---
S
P
QLMNAYLL
G
QQLPEVW
-
DF
GMF
S
I
AKVG
Y
QAQ
VIP
A
L
LAG
L
A
L
GV
IE
TR
L
KRIV
P
DYLYLVVV
P
V
CS
L
IL
AVF
LA
H
A
LIGP
F
G
R
M
I
GDG
V
A
FAVRH
L
MTGS
F
APIGA
A
L
F
G
F
L
Y
APL
V
I
TGVH
QTTL
A
ID
L
QMI
--
QSM
G
GTP
V
W
PL
I
AL
S
NI
AQG
fig|331111.3.peg.2402
Escherichia coli E24377A (1-353/473)
M
MSK
I
NQTDID
R
L
I
EL
VGG
R
GNI
A
T
VS
HC
I
TRLRF
V
L
N
Q
PANARPKE
I
E
QLP
M
V
K
G
C
FT
N
AG
Q
F
QVVIG
TN
V
GD
-
YYQ
A
LIAST
G
QAQV
-
D
KEQVKKAARQNMKWHE---
--
QL
I
SHFAE
IF
F
PL
L
P
AL
I
SG
GL
I
LG
FRN
V
I
GDLPMSNG
Q
T
LAQMYPSL
Q
T
I
----
Y
D
FL
WLI
G
E
A
I
F
F
Y
LP
V
G
I
CW
SA
VKK
M
GGT
PIL
G
IV
LG
VT
LV
---
S
P
QLMNAYLL
G
QQLPEVW
-
DF
GMF
S
I
AKVG
Y
QAQ
VIP
A
L
LAG
L
A
L
GV
IE
TR
L
KRIV
P
DYLYLVVV
P
V
CS
L
IL
AVF
LA
H
A
LIGP
F
G
R
M
I
GDG
V
A
FAVRH
L
MTGS
F
APIGA
A
L
F
G
F
L
Y
APL
V
I
TGVH
QTTL
A
ID
L
QMI
--
QSM
G
GTP
V
W
PL
I
AL
S
NI
AQG
fig|562.375.peg.2828
Escherichia coli EC4100B (1-353/473)
M
MSK
I
NQTDID
R
L
I
EL
VGG
R
GNI
A
T
VS
HC
I
TRLRF
V
L
N
Q
PANARPKE
I
E
QLP
M
V
K
G
C
FT
N
AG
Q
F
QVVIG
TN
V
GD
-
YYQ
A
LIAST
G
QAQV
-
D
KEQVKKAARQNMKWHE---
--
QL
I
SHFAE
IF
F
PL
L
P
AL
I
SG
GL
I
LG
FRN
V
I
GDLPMSNG
Q
T
LAQMYPSL
Q
T
I
----
Y
D
FL
WLI
G
E
A
I
F
F
Y
LP
V
G
I
CW
SA
VKK
M
GGT
PIL
G
IV
LG
VT
LV
---
S
P
QLMNAYLL
G
QQLPEVW
-
DF
GMF
S
I
AKVG
Y
QAQ
VIP
A
L
LAG
L
A
L
GV
IE
TR
L
KRIV
P
DYLYLVVV
P
V
CS
L
IL
AVF
LA
H
A
LIGP
F
G
R
M
I
GDG
V
A
FAVRH
L
MTGS
F
APIGA
A
L
F
G
F
L
Y
APL
V
I
TGVH
QTTL
A
ID
L
QMI
--
QSM
G
GTP
V
W
PL
I
AL
S
NI
AQG
fig|656379.3.peg.618
Escherichia coli FVEC1302 (1-353/473)
M
MSK
I
NQTDID
R
L
I
EL
VGG
R
GNI
A
T
VS
HC
I
TRLRF
V
L
N
Q
PANARPKE
I
E
QLP
M
V
K
G
C
FT
N
AG
Q
F
QVVIG
TN
V
GD
-
YYQ
A
LIAST
G
QAQV
-
D
KEQVKKAARQNMKWHE---
--
QL
I
SHFAE
IF
F
PL
L
P
AL
I
SG
GL
I
LG
FRN
V
I
GDLPMSNG
Q
T
LAQMYPSL
Q
T
I
----
Y
D
FL
WLI
G
E
A
I
F
F
Y
LP
V
G
I
CW
SA
VKK
M
GGT
PIL
G
IV
LG
VT
LV
---
S
P
QLMNAYLL
G
QQLPEVW
-
DF
GMF
S
I
AKVG
Y
QAQ
VIP
A
L
LAG
L
A
L
GV
IE
TR
L
KRIV
P
DYLYLVVV
P
V
CS
L
IL
AVF
LA
H
A
LIGP
F
G
R
M
I
GDG
V
A
FAVRH
L
MTGS
F
APIGA
A
L
F
G
F
L
Y
APL
V
I
TGVH
QTTL
A
ID
L
QMI
--
QSM
G
GTP
V
W
PL
I
AL
S
NI
AQG
fig|656380.3.peg.609
Escherichia coli FVEC1412 (1-353/473)
M
MSK
I
NQTDID
R
L
I
EL
VGG
R
GNI
A
T
VS
HC
I
TRLRF
V
L
N
Q
PANARPKE
I
E
QLP
M
V
K
G
C
FT
N
AG
Q
F
QVVIG
TN
V
GD
-
YYQ
A
LIAST
G
QAQV
-
D
KEQVKKAARQNMKWHE---
--
QL
I
SHFAE
IF
F
PL
L
P
AL
I
SG
GL
I
LG
FRN
V
I
GDLPMSNG
Q
T
LAQMYPSL
Q
T
I
----
Y
D
FL
WLI
G
E
A
I
F
F
Y
LP
V
G
I
CW
SA
VKK
M
GGT
PIL
G
IV
LG
VT
LV
---
S
P
QLMNAYLL
G
QQLPEVW
-
DF
GMF
S
I
AKVG
Y
QAQ
VIP
A
L
LAG
L
A
L
GV
IE
TR
L
KRIV
P
DYLYLVVV
P
V
CS
L
IL
AVF
LA
H
A
LIGP
F
G
R
M
I
GDG
V
A
FAVRH
L
MTGS
F
APIGA
A
L
F
G
F
L
Y
APL
V
I
TGVH
QTTL
A
ID
L
QMI
--
QSM
G
GTP
V
W
PL
I
AL
S
NI
AQG
fig|656408.3.peg.4751
Escherichia coli H591 (1-353/473)
M
MSK
I
NQTDID
R
L
I
EL
VGG
R
GNI
A
T
VS
HC
I
TRLRF
V
L
N
Q
PANARPKE
I
E
QLP
M
V
K
G
C
FT
N
AG
Q
F
QVVIG
TN
V
GD
-
YYQ
A
LIAST
G
QAQV
-
D
KEQVKKAARQNMKWHE---
--
QL
I
SHFAE
IF
F
PL
L
P
AL
I
SG
GL
I
LG
FRN
V
I
GDLPMSNG
Q
T
LAQMYPSL
Q
T
I
----
Y
D
FL
WLI
G
E
A
I
F
F
Y
LP
V
G
I
CW
SA
VKK
M
GGT
PIL
G
IV
LG
VT
LV
---
S
P
QLMNAYLL
G
QQLPEVW
-
DF
GMF
S
I
AKVG
Y
QAQ
VIP
A
L
LAG
L
A
L
GV
IE
TR
L
KRIV
P
DYLYLVVV
P
V
CS
L
IL
AVF
LA
H
A
LIGP
F
G
R
M
I
GDG
V
A
FAVRH
L
MTGS
F
APIGA
A
L
F
G
F
L
Y
APL
V
I
TGVH
QTTL
A
ID
L
QMI
--
QSM
G
GTP
V
W
PL
I
AL
S
NI
AQG
fig|331112.3.peg.4206
Escherichia coli HS (1-353/473)
M
MSK
I
NQTDID
R
L
I
EL
VGG
R
GNI
A
T
VS
HC
I
TRLRF
V
L
N
Q
PANARPKE
I
E
QLP
M
V
K
G
C
FT
N
AG
Q
F
QVVIG
TN
V
GD
-
YYQ
A
LIAST
G
QAQV
-
D
KEQVKKAARQNMKWHE---
--
QL
I
SHFAE
IF
F
PL
L
P
AL
I
SG
GL
I
LG
FRN
V
I
GDLPMSNG
Q
T
LAQMYPSL
Q
T
I
----
Y
D
FL
WLI
G
E
A
I
F
F
Y
LP
V
G
I
CW
SA
VKK
M
GGT
PIL
G
IV
LG
VT
LV
---
S
P
QLMNAYLL
G
QQLPEVW
-
DF
GMF
S
I
AKVG
Y
QAQ
VIP
A
L
LAG
L
A
L
GV
IE
TR
L
KRIV
P
DYLYLVVV
P
V
CS
L
IL
AVF
LA
H
A
LIGP
F
G
R
M
I
GDG
V
A
FAVRH
L
MTGS
F
APIGA
A
L
F
G
F
L
Y
APL
V
I
TGVH
QTTL
A
ID
L
QMI
--
QSM
G
GTP
V
W
PL
I
AL
S
NI
AQG
fig|331112.6.peg.4379
Escherichia coli HS (1-353/473)
M
MSK
I
NQTDID
R
L
I
EL
VGG
R
GNI
A
T
VS
HC
I
TRLRF
V
L
N
Q
PANARPKE
I
E
QLP
M
V
K
G
C
FT
N
AG
Q
F
QVVIG
TN
V
GD
-
YYQ
A
LIAST
G
QAQV
-
D
KEQVKKAARQNMKWHE---
--
QL
I
SHFAE
IF
F
PL
L
P
AL
I
SG
GL
I
LG
FRN
V
I
GDLPMSNG
Q
T
LAQMYPSL
Q
T
I
----
Y
D
FL
WLI
G
E
A
I
F
F
Y
LP
V
G
I
CW
SA
VKK
M
GGT
PIL
G
IV
LG
VT
LV
---
S
P
QLMNAYLL
G
QQLPEVW
-
DF
GMF
S
I
AKVG
Y
QAQ
VIP
A
L
LAG
L
A
L
GV
IE
TR
L
KRIV
P
DYLYLVVV
P
V
CS
L
IL
AVF
LA
H
A
LIGP
F
G
R
M
I
GDG
V
A
FAVRH
L
MTGS
F
APIGA
A
L
F
G
F
L
Y
APL
V
I
TGVH
QTTL
A
ID
L
QMI
--
QSM
G
GTP
V
W
PL
I
AL
S
NI
AQG
fig|595495.4.peg.4243
Escherichia coli KO11 (1-353/473)
M
MSK
I
NQTDID
R
L
I
EL
VGG
R
GNI
A
T
VS
HC
I
TRLRF
V
L
N
Q
PANARPKE
I
E
QLP
M
V
K
G
C
FT
N
AG
Q
F
QVVIG
TN
V
GD
-
YYQ
A
LIAST
G
QAQV
-
D
KEQVKKAARQNMKWHE---
--
QL
I
SHFAE
IF
F
PL
L
P
AL
I
SG
GL
I
LG
FRN
V
I
GDLPMSNG
Q
T
LAQMYPSL
Q
T
I
----
Y
D
FL
WLI
G
E
A
I
F
F
Y
LP
V
G
I
CW
SA
VKK
M
GGT
PIL
G
IV
LG
VT
LV
---
S
P
QLMNAYLL
G
QQLPEVW
-
DF
GMF
S
I
AKVG
Y
QAQ
VIP
A
L
LAG
L
A
L
GV
IE
TR
L
KRIV
P
DYLYLVVV
P
V
CS
L
IL
AVF
LA
H
A
LIGP
F
G
R
M
I
GDG
V
A
FAVRH
L
MTGS
F
APIGA
A
L
F
G
F
L
Y
APL
V
I
TGVH
QTTL
A
ID
L
QMI
--
QSM
G
GTP
V
W
PL
I
AL
S
NI
AQG
fig|749537.3.peg.455
Escherichia coli MS 115-1 (1-353/473)
M
MSK
I
NQTDID
R
L
I
EL
VGG
R
GNI
A
T
VS
HC
I
TRLRF
V
L
N
Q
PANARPKE
I
E
QLP
M
V
K
G
C
FT
N
AG
Q
F
QVVIG
TN
V
GD
-
YYQ
A
LIAST
G
QAQV
-
D
KEQVKKAARQNMKWHE---
--
QL
I
SHFAE
IF
F
PL
L
P
AL
I
SG
GL
I
LG
FRN
V
I
GDLPMSNG
Q
T
LAQMYPSL
Q
T
I
----
Y
D
FL
WLI
G
E
A
I
F
F
Y
LP
V
G
I
CW
SA
VKK
M
GGT
PIL
G
IV
LG
VT
LV
---
S
P
QLMNAYLL
G
QQLPEVW
-
DF
GMF
S
I
AKVG
Y
QAQ
VIP
A
L
LAG
L
A
L
GV
IE
TR
L
KRIV
P
DYLYLVVV
P
V
CS
L
IL
AVF
LA
H
A
LIGP
F
G
R
M
I
GDG
V
A
FAVRH
L
MTGS
F
APIGA
A
L
F
G
F
L
Y
APL
V
I
TGVH
QTTL
A
ID
L
QMI
--
QSM
G
GTP
V
W
PL
I
AL
S
NI
AQG
fig|679206.4.peg.1113
Escherichia coli MS 119-7 (1-353/473)
M
MSK
I
NQTDID
R
L
I
EL
VGG
R
GNI
A
T
VS
HC
I
TRLRF
V
L
N
Q
PANARPKE
I
E
QLP
M
V
K
G
C
FT
N
AG
Q
F
QVVIG
TN
V
GD
-
YYQ
A
LIAST
G
QAQV
-
D
KEQVKKAARQNMKWHE---
--
QL
I
SHFAE
IF
F
PL
L
P
AL
I
SG
GL
I
LG
FRN
V
I
GDLPMSNG
Q
T
LAQMYPSL
Q
T
I
----
Y
D
FL
WLI
G
E
A
I
F
F
Y
LP
V
G
I
CW
SA
VKK
M
GGT
PIL
G
IV
LG
VT
LV
---
S
P
QLMNAYLL
G
QQLPEVW
-
DF
GMF
S
I
AKVG
Y
QAQ
VIP
A
L
LAG
L
A
L
GV
IE
TR
L
KRIV
P
DYLYLVVV
P
V
CS
L
IL
AVF
LA
H
A
LIGP
F
G
R
M
I
GDG
V
A
FAVRH
L
MTGS
F
APIGA
A
L
F
G
F
L
Y
APL
V
I
TGVH
QTTL
A
ID
L
QMI
--
QSM
G
GTP
V
W
PL
I
AL
S
NI
AQG
fig|749540.3.peg.3142
Escherichia coli MS 146-1 (1-353/473)
M
MSK
I
NQTDID
R
L
I
EL
VGG
R
GNI
A
T
VS
HC
I
TRLRF
V
L
N
Q
PANARPKE
I
E
QLP
M
V
K
G
C
FT
N
AG
Q
F
QVVIG
TN
V
GD
-
YYQ
A
LIAST
G
QAQV
-
D
KEQVKKAARQNMKWHE---
--
QL
I
SHFAE
IF
F
PL
L
P
AL
I
SG
GL
I
LG
FRN
V
I
GDLPMSNG
Q
T
LAQMYPSL
Q
T
I
----
Y
D
FL
WLI
G
E
A
I
F
F
Y
LP
V
G
I
CW
SA
VKK
M
GGT
PIL
G
IV
LG
VT
LV
---
S
P
QLMNAYLL
G
QQLPEVW
-
DF
GMF
S
I
AKVG
Y
QAQ
VIP
A
L
LAG
L
A
L
GV
IE
TR
L
KRIV
P
DYLYLVVV
P
V
CS
L
IL
AVF
LA
H
A
LIGP
F
G
R
M
I
GDG
V
A
FAVRH
L
MTGS
F
APIGA
A
L
F
G
F
L
Y
APL
V
I
TGVH
QTTL
A
ID
L
QMI
--
QSM
G
GTP
V
W
PL
I
AL
S
NI
AQG
fig|749549.3.peg.3287
Escherichia coli MS 198-1 (1-353/473)
M
MSK
I
NQTDID
R
L
I
EL
VGG
R
GNI
A
T
VS
HC
I
TRLRF
V
L
N
Q
PANARPKE
I
E
QLP
M
V
K
G
C
FT
N
AG
Q
F
QVVIG
TN
V
GD
-
YYQ
A
LIAST
G
QAQV
-
D
KEQVKKAARQNMKWHE---
--
QL
I
SHFAE
IF
F
PL
L
P
AL
I
SG
GL
I
LG
FRN
V
I
GDLPMSNG
Q
T
LAQMYPSL
Q
T
I
----
Y
D
FL
WLI
G
E
A
I
F
F
Y
LP
V
G
I
CW
SA
VKK
M
GGT
PIL
G
IV
LG
VT
LV
---
S
P
QLMNAYLL
G
QQLPEVW
-
DF
GMF
S
I
AKVG
Y
QAQ
VIP
A
L
LAG
L
A
L
GV
IE
TR
L
KRIV
P
DYLYLVVV
P
V
CS
L
IL
AVF
LA
H
A
LIGP
F
G
R
M
I
GDG
V
A
FAVRH
L
MTGS
F
APIGA
A
L
F
G
F
L
Y
APL
V
I
TGVH
QTTL
A
ID
L
QMI
--
QSM
G
GTP
V
W
PL
I
AL
S
NI
AQG
fig|585395.4.peg.5295
Escherichia coli O103:H2 str. 12009 (1-353/473)
M
MSK
I
NQTDID
R
L
I
EL
VGG
R
GNI
A
T
VS
HC
I
TRLRF
V
L
N
Q
PANARPKE
I
E
QLP
M
V
K
G
C
FT
N
AG
Q
F
QVVIG
TN
V
GD
-
YYQ
A
LIAST
G
QAQV
-
D
KEQVKKAARQNMKWHE---
--
QL
I
SHFAE
IF
F
PL
L
P
AL
I
SG
GL
I
LG
FRN
V
I
GDLPMSNG
Q
T
LAQMYPSL
Q
T
I
----
Y
D
FL
WLI
G
E
A
I
F
F
Y
LP
V
G
I
CW
SA
VKK
M
GGT
PIL
G
IV
LG
VT
LV
---
S
P
QLMNAYLL
G
QQLPEVW
-
DF
GMF
S
I
AKVG
Y
QAQ
VIP
A
L
LAG
L
A
L
GV
IE
TR
L
KRIV
P
DYLYLVVV
P
V
CS
L
IL
AVF
LA
H
A
LIGP
F
G
R
M
I
GDG
V
A
FAVRH
L
MTGS
F
APIGA
A
L
F
G
F
L
Y
APL
V
I
TGVH
QTTL
A
ID
L
QMI
--
QSM
G
GTP
V
W
PL
I
AL
S
NI
AQG
fig|585396.4.peg.5342
Escherichia coli O111:H- str. 11128 (1-353/473)
M
MSK
I
NQTDID
R
L
I
EL
VGG
R
GNI
A
T
VS
HC
I
TRLRF
V
L
N
Q
PANARPKE
I
E
QLP
M
V
K
G
C
FT
N
AG
Q
F
QVVIG
TN
V
GD
-
YYQ
A
LIAST
G
QAQV
-
D
KEQVKKAARQNMKWHE---
--
QL
I
SHFAE
IF
F
PL
L
P
AL
I
SG
GL
I
LG
FRN
V
I
GDLPMSNG
Q
T
LAQMYPSL
Q
T
I
----
Y
D
FL
WLI
G
E
A
I
F
F
Y
LP
V
G
I
CW
SA
VKK
M
GGT
PIL
G
IV
LG
VT
LV
---
S
P
QLMNAYLL
G
QQLPEVW
-
DF
GMF
S
I
AKVG
Y
QAQ
VIP
A
L
LAG
L
A
L
GV
IE
TR
L
KRIV
P
DYLYLVVV
P
V
CS
L
IL
AVF
LA
H
A
LIGP
F
G
R
M
I
GDG
V
A
FAVRH
L
MTGS
F
APIGA
A
L
F
G
F
L
Y
APL
V
I
TGVH
QTTL
A
ID
L
QMI
--
QSM
G
GTP
V
W
PL
I
AL
S
NI
AQG
fig|585056.7.peg.4938
Escherichia coli UMN026 (1-353/473)
M
MSK
I
NQTDID
R
L
I
EL
VGG
R
GNI
A
T
VS
HC
I
TRLRF
V
L
N
Q
PANARPKE
I
E
QLP
M
V
K
G
C
FT
N
AG
Q
F
QVVIG
TN
V
GD
-
YYQ
A
LIAST
G
QAQV
-
D
KEQVKKAARQNMKWHE---
--
QL
I
SHFAE
IF
F
PL
L
P
AL
I
SG
GL
I
LG
FRN
V
I
GDLPMSNG
Q
T
LAQMYPSL
Q
T
I
----
Y
D
FL
WLI
G
E
A
I
F
F
Y
LP
V
G
I
CW
SA
VKK
M
GGT
PIL
G
IV
LG
VT
LV
---
S
P
QLMNAYLL
G
QQLPEVW
-
DF
GMF
S
I
AKVG
Y
QAQ
VIP
A
L
LAG
L
A
L
GV
IE
TR
L
KRIV
P
DYLYLVVV
P
V
CS
L
IL
AVF
LA
H
A
LIGP
F
G
R
M
I
GDG
V
A
FAVRH
L
MTGS
F
APIGA
A
L
F
G
F
L
Y
APL
V
I
TGVH
QTTL
A
ID
L
QMI
--
QSM
G
GTP
V
W
PL
I
AL
S
NI
AQG
fig|566546.3.peg.3075
Escherichia coli W (1-353/473)
M
MSK
I
NQTDID
R
L
I
EL
VGG
R
GNI
A
T
VS
HC
I
TRLRF
V
L
N
Q
PANARPKE
I
E
QLP
M
V
K
G
C
FT
N
AG
Q
F
QVVIG
TN
V
GD
-
YYQ
A
LIAST
G
QAQV
-
D
KEQVKKAARQNMKWHE---
--
QL
I
SHFAE
IF
F
PL
L
P
AL
I
SG
GL
I
LG
FRN
V
I
GDLPMSNG
Q
T
LAQMYPSL
Q
T
I
----
Y
D
FL
WLI
G
E
A
I
F
F
Y
LP
V
G
I
CW
SA
VKK
M
GGT
PIL
G
IV
LG
VT
LV
---
S
P
QLMNAYLL
G
QQLPEVW
-
DF
GMF
S
I
AKVG
Y
QAQ
VIP
A
L
LAG
L
A
L
GV
IE
TR
L
KRIV
P
DYLYLVVV
P
V
CS
L
IL
AVF
LA
H
A
LIGP
F
G
R
M
I
GDG
V
A
FAVRH
L
MTGS
F
APIGA
A
L
F
G
F
L
Y
APL
V
I
TGVH
QTTL
A
ID
L
QMI
--
QSM
G
GTP
V
W
PL
I
AL
S
NI
AQG
fig|566546.4.peg.4536
Escherichia coli W (1-353/473)
M
MSK
I
NQTDID
R
L
I
EL
VGG
R
GNI
A
T
VS
HC
I
TRLRF
V
L
N
Q
PANARPKE
I
E
QLP
M
V
K
G
C
FT
N
AG
Q
F
QVVIG
TN
V
GD
-
YYQ
A
LIAST
G
QAQV
-
D
KEQVKKAARQNMKWHE---
--
QL
I
SHFAE
IF
F
PL
L
P
AL
I
SG
GL
I
LG
FRN
V
I
GDLPMSNG
Q
T
LAQMYPSL
Q
T
I
----
Y
D
FL
WLI
G
E
A
I
F
F
Y
LP
V
G
I
CW
SA
VKK
M
GGT
PIL
G
IV
LG
VT
LV
---
S
P
QLMNAYLL
G
QQLPEVW
-
DF
GMF
S
I
AKVG
Y
QAQ
VIP
A
L
LAG
L
A
L
GV
IE
TR
L
KRIV
P
DYLYLVVV
P
V
CS
L
IL
AVF
LA
H
A
LIGP
F
G
R
M
I
GDG
V
A
FAVRH
L
MTGS
F
APIGA
A
L
F
G
F
L
Y
APL
V
I
TGVH
QTTL
A
ID
L
QMI
--
QSM
G
GTP
V
W
PL
I
AL
S
NI
AQG
fig|362663.8.peg.4522
Escherichia coli 536 (1-353/473)
M
MSK
I
NQTDID
R
L
I
EL
VGG
R
GNI
A
T
VS
HC
I
TRLRF
V
L
N
Q
PANARPKE
I
E
QLP
M
V
K
G
C
FT
N
AG
Q
F
QVVIG
TN
V
GD
-
YYQ
A
LIAST
G
QAQV
-
D
KEQVKKAARQNMKCHE---
--
QL
I
SHFAE
IF
F
PL
L
P
AL
I
SG
GL
I
LG
FRN
V
I
GDLPMSNG
Q
T
LAQMYPSL
Q
T
I
----
Y
D
FL
WLI
G
E
A
I
F
F
Y
LP
V
G
I
CW
SA
VKK
M
GGT
PIL
G
IV
LG
VT
LV
---
S
P
QLMNAYLL
G
QQLPEVW
-
DF
GMF
S
I
AKVG
Y
QAQ
VIP
A
L
LAG
L
A
L
GV
IE
TR
L
KRIV
P
DYLYLVVV
P
V
CS
L
IL
AVF
LA
H
A
LIGP
F
G
R
M
I
GDG
V
A
FAVRH
L
MTGS
F
APIGA
A
L
F
G
F
L
Y
APL
V
I
TGVH
QTTL
A
ID
L
QMI
--
QSM
G
GTP
V
W
PL
I
AL
S
NI
AQG
fig|362663.9.peg.4538
Escherichia coli 536 (1-353/473)
M
MSK
I
NQTDID
R
L
I
EL
VGG
R
GNI
A
T
VS
HC
I
TRLRF
V
L
N
Q
PANARPKE
I
E
QLP
M
V
K
G
C
FT
N
AG
Q
F
QVVIG
TN
V
GD
-
YYQ
A
LIAST
G
QAQV
-
D
KEQVKKAARQNMKCHE---
--
QL
I
SHFAE
IF
F
PL
L
P
AL
I
SG
GL
I
LG
FRN
V
I
GDLPMSNG
Q
T
LAQMYPSL
Q
T
I
----
Y
D
FL
WLI
G
E
A
I
F
F
Y
LP
V
G
I
CW
SA
VKK
M
GGT
PIL
G
IV
LG
VT
LV
---
S
P
QLMNAYLL
G
QQLPEVW
-
DF
GMF
S
I
AKVG
Y
QAQ
VIP
A
L
LAG
L
A
L
GV
IE
TR
L
KRIV
P
DYLYLVVV
P
V
CS
L
IL
AVF
LA
H
A
LIGP
F
G
R
M
I
GDG
V
A
FAVRH
L
MTGS
F
APIGA
A
L
F
G
F
L
Y
APL
V
I
TGVH
QTTL
A
ID
L
QMI
--
QSM
G
GTP
V
W
PL
I
AL
S
NI
AQG
fig|340197.3.peg.899
Escherichia coli F11 (1-353/473)
M
MSK
I
NQTDID
R
L
I
EL
VGG
R
GNI
A
T
VS
HC
I
TRLRF
V
L
N
Q
PANARPKE
I
E
QLP
M
V
K
G
C
FT
N
AG
Q
F
QVVIG
TN
V
GD
-
YYQ
A
LIAST
G
QAQV
-
D
KEQVKKAARQNMKCHE---
--
QL
I
SHFAE
IF
F
PL
L
P
AL
I
SG
GL
I
LG
FRN
V
I
GDLPMSNG
Q
T
LAQMYPSL
Q
T
I
----
Y
D
FL
WLI
G
E
A
I
F
F
Y
LP
V
G
I
CW
SA
VKK
M
GGT
PIL
G
IV
LG
VT
LV
---
S
P
QLMNAYLL
G
QQLPEVW
-
DF
GMF
S
I
AKVG
Y
QAQ
VIP
A
L
LAG
L
A
L
GV
IE
TR
L
KRIV
P
DYLYLVVV
P
V
CS
L
IL
AVF
LA
H
A
LIGP
F
G
R
M
I
GDG
V
A
FAVRH
L
MTGS
F
APIGA
A
L
F
G
F
L
Y
APL
V
I
TGVH
QTTL
A
ID
L
QMI
--
QSM
G
GTP
V
W
PL
I
AL
S
NI
AQG
fig|340197.5.peg.950
Escherichia coli F11 (1-353/473)
M
MSK
I
NQTDID
R
L
I
EL
VGG
R
GNI
A
T
VS
HC
I
TRLRF
V
L
N
Q
PANARPKE
I
E
QLP
M
V
K
G
C
FT
N
AG
Q
F
QVVIG
TN
V
GD
-
YYQ
A
LIAST
G
QAQV
-
D
KEQVKKAARQNMKCHE---
--
QL
I
SHFAE
IF
F
PL
L
P
AL
I
SG
GL
I
LG
FRN
V
I
GDLPMSNG
Q
T
LAQMYPSL
Q
T
I
----
Y
D
FL
WLI
G
E
A
I
F
F
Y
LP
V
G
I
CW
SA
VKK
M
GGT
PIL
G
IV
LG
VT
LV
---
S
P
QLMNAYLL
G
QQLPEVW
-
DF
GMF
S
I
AKVG
Y
QAQ
VIP
A
L
LAG
L
A
L
GV
IE
TR
L
KRIV
P
DYLYLVVV
P
V
CS
L
IL
AVF
LA
H
A
LIGP
F
G
R
M
I
GDG
V
A
FAVRH
L
MTGS
F
APIGA
A
L
F
G
F
L
Y
APL
V
I
TGVH
QTTL
A
ID
L
QMI
--
QSM
G
GTP
V
W
PL
I
AL
S
NI
AQG
fig|749550.3.peg.3349
Escherichia coli MS 200-1 (1-353/473)
M
MSK
I
NQTDID
R
L
I
EL
VGG
R
GNI
A
T
VS
HC
I
TRLRF
V
L
N
Q
PANARPKE
I
E
QLP
M
V
K
G
C
FT
N
AG
Q
F
QVVIG
TN
V
GD
-
YYQ
A
LIAST
G
QAQV
-
D
KEQVKKAARQNMKCHE---
--
QL
I
SHFAE
IF
F
PL
L
P
AL
I
SG
GL
I
LG
FRN
V
I
GDLPMSNG
Q
T
LAQMYPSL
Q
T
I
----
Y
D
FL
WLI
G
E
A
I
F
F
Y
LP
V
G
I
CW
SA
VKK
M
GGT
PIL
G
IV
LG
VT
LV
---
S
P
QLMNAYLL
G
QQLPEVW
-
DF
GMF
S
I
AKVG
Y
QAQ
VIP
A
L
LAG
L
A
L
GV
IE
TR
L
KRIV
P
DYLYLVVV
P
V
CS
L
IL
AVF
LA
H
A
LIGP
F
G
R
M
I
GDG
V
A
FAVRH
L
MTGS
F
APIGA
A
L
F
G
F
L
Y
APL
V
I
TGVH
QTTL
A
ID
L
QMI
--
QSM
G
GTP
V
W
PL
I
AL
S
NI
AQG
fig|595496.3.peg.4315
Escherichia coli BW2952 (1-353/473)
M
MSK
I
NQTDID
R
L
I
EL
VGG
R
GNI
A
T
VS
HC
I
TRLRF
V
L
N
Q
PANARPKE
I
E
QLP
M
V
K
G
C
FT
N
AG
Q
F
QVVIG
TN
V
GD
-
YYQ
A
LIAST
G
QAQV
-
D
KEQVKKAARHNMKWHE---
--
QL
I
SHFAV
IF
F
PL
L
P
AL
I
SG
GL
I
LG
FRN
V
I
GDLPMSNG
Q
T
LAQMYPSL
Q
T
I
----
Y
D
FL
WLI
G
E
A
I
F
F
Y
LP
V
G
I
CW
SA
VKK
M
GGT
PIL
G
IV
LG
VT
LV
---
S
P
QLMNAYLL
G
QQLPEVW
-
DF
GMF
S
I
AKVG
Y
QAQ
VIP
A
L
LAG
L
A
L
GV
IE
TR
L
KRIV
P
DYLYLVVV
P
V
CS
L
IL
AVF
LA
H
A
LIGP
F
G
R
M
I
GDG
V
A
FAVRH
L
MTGS
F
APIGA
A
L
F
G
F
L
Y
APL
V
I
TGVH
QTTL
A
ID
L
QMI
--
QSM
G
GTP
V
W
PL
I
AL
S
NI
AQG
fig|536056.3.peg.3986
Escherichia coli DH1 (1-353/473)
M
MSK
I
NQTDID
R
L
I
EL
VGG
R
GNI
A
T
VS
HC
I
TRLRF
V
L
N
Q
PANARPKE
I
E
QLP
M
V
K
G
C
FT
N
AG
Q
F
QVVIG
TN
V
GD
-
YYQ
A
LIAST
G
QAQV
-
D
KEQVKKAARHNMKWHE---
--
QL
I
SHFAV
IF
F
PL
L
P
AL
I
SG
GL
I
LG
FRN
V
I
GDLPMSNG
Q
T
LAQMYPSL
Q
T
I
----
Y
D
FL
WLI
G
E
A
I
F
F
Y
LP
V
G
I
CW
SA
VKK
M
GGT
PIL
G
IV
LG
VT
LV
---
S
P
QLMNAYLL
G
QQLPEVW
-
DF
GMF
S
I
AKVG
Y
QAQ
VIP
A
L
LAG
L
A
L
GV
IE
TR
L
KRIV
P
DYLYLVVV
P
V
CS
L
IL
AVF
LA
H
A
LIGP
F
G
R
M
I
GDG
V
A
FAVRH
L
MTGS
F
APIGA
A
L
F
G
F
L
Y
APL
V
I
TGVH
QTTL
A
ID
L
QMI
--
QSM
G
GTP
V
W
PL
I
AL
S
NI
AQG
fig|83333.1.peg.4150
Escherichia coli K12 (1-353/473)
M
MSK
I
NQTDID
R
L
I
EL
VGG
R
GNI
A
T
VS
HC
I
TRLRF
V
L
N
Q
PANARPKE
I
E
QLP
M
V
K
G
C
FT
N
AG
Q
F
QVVIG
TN
V
GD
-
YYQ
A
LIAST
G
QAQV
-
D
KEQVKKAARHNMKWHE---
--
QL
I
SHFAV
IF
F
PL
L
P
AL
I
SG
GL
I
LG
FRN
V
I
GDLPMSNG
Q
T
LAQMYPSL
Q
T
I
----
Y
D
FL
WLI
G
E
A
I
F
F
Y
LP
V
G
I
CW
SA
VKK
M
GGT
PIL
G
IV
LG
VT
LV
---
S
P
QLMNAYLL
G
QQLPEVW
-
DF
GMF
S
I
AKVG
Y
QAQ
VIP
A
L
LAG
L
A
L
GV
IE
TR
L
KRIV
P
DYLYLVVV
P
V
CS
L
IL
AVF
LA
H
A
LIGP
F
G
R
M
I
GDG
V
A
FAVRH
L
MTGS
F
APIGA
A
L
F
G
F
L
Y
APL
V
I
TGVH
QTTL
A
ID
L
QMI
--
QSM
G
GTP
V
W
PL
I
AL
S
NI
AQG
fig|316407.3.peg.4074
Escherichia coli W3110 (1-353/473)
M
MSK
I
NQTDID
R
L
I
EL
VGG
R
GNI
A
T
VS
HC
I
TRLRF
V
L
N
Q
PANARPKE
I
E
QLP
M
V
K
G
C
FT
N
AG
Q
F
QVVIG
TN
V
GD
-
YYQ
A
LIAST
G
QAQV
-
D
KEQVKKAARHNMKWHE---
--
QL
I
SHFAV
IF
F
PL
L
P
AL
I
SG
GL
I
LG
FRN
V
I
GDLPMSNG
Q
T
LAQMYPSL
Q
T
I
----
Y
D
FL
WLI
G
E
A
I
F
F
Y
LP
V
G
I
CW
SA
VKK
M
GGT
PIL
G
IV
LG
VT
LV
---
S
P
QLMNAYLL
G
QQLPEVW
-
DF
GMF
S
I
AKVG
Y
QAQ
VIP
A
L
LAG
L
A
L
GV
IE
TR
L
KRIV
P
DYLYLVVV
P
V
CS
L
IL
AVF
LA
H
A
LIGP
F
G
R
M
I
GDG
V
A
FAVRH
L
MTGS
F
APIGA
A
L
F
G
F
L
Y
APL
V
I
TGVH
QTTL
A
ID
L
QMI
--
QSM
G
GTP
V
W
PL
I
AL
S
NI
AQG
fig|316385.7.peg.4480
Escherichia coli str. K-12 substr. DH10B (1-353/473)
M
MSK
I
NQTDID
R
L
I
EL
VGG
R
GNI
A
T
VS
HC
I
TRLRF
V
L
N
Q
PANARPKE
I
E
QLP
M
V
K
G
C
FT
N
AG
Q
F
QVVIG
TN
V
GD
-
YYQ
A
LIAST
G
QAQV
-
D
KEQVKKAARHNMKWHE---
--
QL
I
SHFAV
IF
F
PL
L
P
AL
I
SG
GL
I
LG
FRN
V
I
GDLPMSNG
Q
T
LAQMYPSL
Q
T
I
----
Y
D
FL
WLI
G
E
A
I
F
F
Y
LP
V
G
I
CW
SA
VKK
M
GGT
PIL
G
IV
LG
VT
LV
---
S
P
QLMNAYLL
G
QQLPEVW
-
DF
GMF
S
I
AKVG
Y
QAQ
VIP
A
L
LAG
L
A
L
GV
IE
TR
L
KRIV
P
DYLYLVVV
P
V
CS
L
IL
AVF
LA
H
A
LIGP
F
G
R
M
I
GDG
V
A
FAVRH
L
MTGS
F
APIGA
A
L
F
G
F
L
Y
APL
V
I
TGVH
QTTL
A
ID
L
QMI
--
QSM
G
GTP
V
W
PL
I
AL
S
NI
AQG
fig|511145.12.peg.4372
Escherichia coli str. K-12 substr. MG1655 (1-353/473)
M
MSK
I
NQTDID
R
L
I
EL
VGG
R
GNI
A
T
VS
HC
I
TRLRF
V
L
N
Q
PANARPKE
I
E
QLP
M
V
K
G
C
FT
N
AG
Q
F
QVVIG
TN
V
GD
-
YYQ
A
LIAST
G
QAQV
-
D
KEQVKKAARHNMKWHE---
--
QL
I
SHFAV
IF
F
PL
L
P
AL
I
SG
GL
I
LG
FRN
V
I
GDLPMSNG
Q
T
LAQMYPSL
Q
T
I
----
Y
D
FL
WLI
G
E
A
I
F
F
Y
LP
V
G
I
CW
SA
VKK
M
GGT
PIL
G
IV
LG
VT
LV
---
S
P
QLMNAYLL
G
QQLPEVW
-
DF
GMF
S
I
AKVG
Y
QAQ
VIP
A
L
LAG
L
A
L
GV
IE
TR
L
KRIV
P
DYLYLVVV
P
V
CS
L
IL
AVF
LA
H
A
LIGP
F
G
R
M
I
GDG
V
A
FAVRH
L
MTGS
F
APIGA
A
L
F
G
F
L
Y
APL
V
I
TGVH
QTTL
A
ID
L
QMI
--
QSM
G
GTP
V
W
PL
I
AL
S
NI
AQG
fig|511145.6.peg.4350
Escherichia coli str. K-12 substr. MG1655 (1-353/473)
M
MSK
I
NQTDID
R
L
I
EL
VGG
R
GNI
A
T
VS
HC
I
TRLRF
V
L
N
Q
PANARPKE
I
E
QLP
M
V
K
G
C
FT
N
AG
Q
F
QVVIG
TN
V
GD
-
YYQ
A
LIAST
G
QAQV
-
D
KEQVKKAARHNMKWHE---
--
QL
I
SHFAV
IF
F
PL
L
P
AL
I
SG
GL
I
LG
FRN
V
I
GDLPMSNG
Q
T
LAQMYPSL
Q
T
I
----
Y
D
FL
WLI
G
E
A
I
F
F
Y
LP
V
G
I
CW
SA
VKK
M
GGT
PIL
G
IV
LG
VT
LV
---
S
P
QLMNAYLL
G
QQLPEVW
-
DF
GMF
S
I
AKVG
Y
QAQ
VIP
A
L
LAG
L
A
L
GV
IE
TR
L
KRIV
P
DYLYLVVV
P
V
CS
L
IL
AVF
LA
H
A
LIGP
F
G
R
M
I
GDG
V
A
FAVRH
L
MTGS
F
APIGA
A
L
F
G
F
L
Y
APL
V
I
TGVH
QTTL
A
ID
L
QMI
--
QSM
G
GTP
V
W
PL
I
AL
S
NI
AQG
fig|749550.3.peg.730
Escherichia coli MS 200-1 (10-342/456)
LL
PL
L
GG
K
E
NI
A
S
AA
HC
A
TRLR
L
V
L
V
D
DTLADQHA
I
G
QID
GV
K
G
C
FR
N
SG
Q
M
Q
I
IF
G
TG
V
GN
K
VYA
A
FIQVA
G
ISES
-
S
KADTARLAAQKLNPFQ---
--
RI
A
RLLSN
IF
V
P
I
IP
AI
V
AS
GLL
M
G
LLG
MV
--------
K
T
YGWVNAD-
N
A
I
----
Y
I
L
L
DMC
S
S
A
A
F
I
I
LPI
L
I
GF
T
A
ARE
FGG
N
PYL
G
AT
LG
GI
L
T
---
HP
ALTNAWGV
A
AGFQTMN
-
F
F
G-F
E
I
AMIG
Y
QGT
V
F
P
V
L
LAV
W
F
M
SI
V
E
KQ
L
RRFI
P
DALDLILT
P
F
LT
V
V
I
SGF
I
A
L
L
I
IGP
A
G
R
A
L
GDG
IS
FVLST
L
IAHA
-
GWLAG
L
L
F
G
G
L
Y
SAI
V
I
TG
I
H
HSFH
A
IE
A
GLL
GN
PAI
G
VNF
L
L
P
I
W
AM
A
NV
AQG
fig|656417.3.peg.3525
Escherichia coli M605 (10-342/456)
LL
PL
L
GG
K
E
NI
A
S
AA
HC
A
TRLR
L
V
L
V
D
DTLADQHA
I
G
QID
GV
K
G
C
FR
N
SG
Q
M
Q
I
IF
G
TG
V
VN
K
VYA
A
FIQVA
G
ISES
-
S
KADTARLAAQKLNPFQ---
--
RI
A
RLLSN
IF
V
P
I
IP
AI
V
AS
GLL
M
G
LLG
MV
--------
K
T
YGWVNAD-
N
A
I
----
Y
I
L
L
DMC
S
S
A
A
F
I
I
LPI
L
I
GF
T
A
ARE
FGG
N
PYL
G
AT
LG
GI
L
T
---
HP
ALTNAWGV
A
AGFQTMD
-
F
F
G-F
E
I
AMIG
Y
QGT
V
F
P
V
L
LAV
W
F
M
SI
V
E
KQ
L
RRFI
P
DALDLILT
P
F
LT
V
V
I
SGF
I
A
L
L
I
IGP
A
G
R
A
L
GDG
IS
FVLST
L
IAHA
-
GWLAG
L
L
F
G
G
L
Y
SAI
V
I
TG
I
H
HSFH
A
IE
A
GLL
GN
PAI
G
VNF
L
L
P
I
W
AM
A
NV
AQG
fig|679205.4.peg.1056
Escherichia coli MS 124-1 (10-342/456)
LL
PL
L
GG
K
E
NI
A
S
AA
HC
A
TRLR
L
V
L
V
D
DTLADQHA
I
G
QID
GV
K
G
C
FR
N
SG
Q
M
Q
I
IF
G
TG
V
VN
K
VYA
A
FIQVA
G
ISES
-
S
KADIARLAAQKLNPFQ---
--
RI
A
RLLSN
IF
V
P
I
IP
AI
V
AS
GLL
M
G
LLG
MV
--------
K
T
YGWVNTD-
N
A
I
----
Y
I
L
L
DMC
S
S
A
A
F
I
I
LPI
L
I
GF
T
A
ARE
FGG
N
PYL
G
AT
LG
GI
L
T
---
HP
ALTNAWGV
A
AGFQTMN
-
F
F
G-F
E
I
AMIG
Y
QGT
V
F
P
V
L
LAV
W
F
M
SI
V
E
KQ
L
RRFI
P
DALDLILT
P
F
LT
V
V
I
SGF
I
A
L
L
I
IGP
A
G
R
A
L
GDG
IS
FVLST
L
IAHA
-
GWLAG
L
L
F
G
G
L
Y
SAI
V
I
TG
I
H
HSFH
A
IE
A
GLL
GN
PAI
G
VNF
L
L
P
I
W
AM
A
NV
AQG
fig|749533.3.peg.3705
Escherichia coli MS 84-1 (10-342/456)
LL
PL
L
GG
K
E
NI
A
S
AA
HC
A
TRLR
L
V
L
V
D
DTLADQHA
I
G
QID
GV
K
G
C
FR
N
SG
Q
M
Q
I
IF
G
TG
V
VN
K
VYA
A
FIQVA
G
ISES
-
S
KADIARLAAQKLNPFQ---
--
RI
A
RLLSN
IF
V
P
I
IP
AI
V
AS
GLL
M
G
LLG
MV
--------
K
T
YGWVNTD-
N
A
I
----
Y
I
L
L
DMC
S
S
A
A
F
I
I
LPI
L
I
GF
T
A
ARE
FGG
N
PYL
G
AT
LG
GI
L
T
---
HP
ALTNAWGV
A
AGFQTMN
-
F
F
G-F
E
I
AMIG
Y
QGT
V
F
P
V
L
LAV
W
F
M
SI
V
E
KQ
L
RRFI
P
DALDLILT
P
F
LT
V
V
I
SGF
I
A
L
L
I
IGP
A
G
R
A
L
GDG
IS
FVLST
L
IAHA
-
GWLAG
L
L
F
G
G
L
Y
SAI
V
I
TG
I
H
HSFH
A
IE
A
GLL
GN
PAI
G
VNF
L
L
P
I
W
AM
A
NV
AQG
fig|749537.3.peg.3294
Escherichia coli MS 115-1 (10-342/456)
LL
PL
L
GG
K
E
NI
A
S
AA
HC
A
TRLR
L
V
L
V
D
DSLADQQA
I
G
KID
GV
K
G
C
FR
N
AG
Q
M
Q
I
IF
G
TG
V
VN
K
VYA
A
FIQAA
G
IGES
-
S
KSEAADIAAKKLNPFQ---
--
RI
A
RLLSN
IF
V
P
I
IP
AI
V
AS
GLL
M
G
LLG
MV
--------
K
T
YGWVDPG-
N
A
I
----
Y
I
M
L
DMC
S
S
A
A
F
I
I
LPI
L
I
GF
T
A
ARE
FGG
N
PYL
G
AT
LG
GI
L
T
---
HP
ALTNAWGV
A
AGFHTMN
-
F
F
G-L
E
I
AMIG
Y
QGT
V
F
P
V
L
LAV
W
F
M
SI
V
E
KQ
L
RRVI
P
DALDLILT
P
F
LT
V
I
I
SGF
I
A
L
L
I
IGP
A
G
R
A
L
GDG
IS
FVLST
L
ITHA
-
GWLAG
L
L
F
G
G
L
Y
SVI
V
I
TG
I
H
HSFH
A
IE
A
GLL
GN
PSI
G
VNF
L
L
P
I
W
AM
A
NV
AQG
fig|670897.3.peg.684
Escherichia coli 2362-75 (10-342/456)
LL
PL
L
GG
K
E
NI
A
S
AA
HC
A
TRLR
L
V
L
V
D
DTLADQHA
I
G
QID
GV
K
G
C
FR
N
SG
Q
M
Q
I
IF
G
TG
V
VN
K
VYA
A
FIQVA
G
ISES
-
S
KADTARLAAQKLNPFQ---
--
RI
A
RLLSN
IF
V
P
I
IP
AI
V
AS
GLL
M
G
LLG
MV
--------
K
T
YGWVNAD-
N
A
I
----
Y
I
L
L
DMC
S
S
A
A
F
I
I
LPI
L
I
GF
T
A
ARE
FGG
N
PYL
G
AT
LG
GI
L
T
---
HP
ALTNAWGV
A
AGFQTMN
-
F
F
G-F
E
I
AMIG
Y
QGT
V
F
P
V
L
LAV
W
F
M
SI
V
E
KQ
L
RRFI
P
DALDLILT
P
F
LT
V
V
I
SGF
I
A
L
L
I
IGP
A
G
R
A
L
GDG
IS
FVLST
L
IAHA
-
GWLAG
L
L
F
G
G
L
Y
SAI
V
I
TG
I
H
HSFH
A
IE
A
GLL
GN
PAI
G
VNF
L
L
P
I
W
AM
A
NV
AQG
fig|362663.8.peg.2786
Escherichia coli 536 (10-342/456)
LL
PL
L
GG
K
E
NI
A
S
AA
HC
A
TRLR
L
V
L
V
D
DTLADQHA
I
G
QID
GV
K
G
C
FR
N
SG
Q
M
Q
I
IF
G
TG
V
VN
K
VYA
A
FIQVA
G
ISES
-
S
KADTARLAAQKLNPFQ---
--
RI
A
RLLSN
IF
V
P
I
IP
AI
V
AS
GLL
M
G
LLG
MV
--------
K
T
YGWVNAD-
N
A
I
----
Y
I
L
L
DMC
S
S
A
A
F
I
I
LPI
L
I
GF
T
A
ARE
FGG
N
PYL
G
AT
LG
GI
L
T
---
HP
ALTNAWGV
A
AGFQTMN
-
F
F
G-F
E
I
AMIG
Y
QGT
V
F
P
V
L
LAV
W
F
M
SI
V
E
KQ
L
RRFI
P
DALDLILT
P
F
LT
V
V
I
SGF
I
A
L
L
I
IGP
A
G
R
A
L
GDG
IS
FVLST
L
IAHA
-
GWLAG
L
L
F
G
G
L
Y
SAI
V
I
TG
I
H
HSFH
A
IE
A
GLL
GN
PAI
G
VNF
L
L
P
I
W
AM
A
NV
AQG
fig|362663.9.peg.2792
Escherichia coli 536 (10-342/456)
LL
PL
L
GG
K
E
NI
A
S
AA
HC
A
TRLR
L
V
L
V
D
DTLADQHA
I
G
QID
GV
K
G
C
FR
N
SG
Q
M
Q
I
IF
G
TG
V
VN
K
VYA
A
FIQVA
G
ISES
-
S
KADTARLAAQKLNPFQ---
--
RI
A
RLLSN
IF
V
P
I
IP
AI
V
AS
GLL
M
G
LLG
MV
--------
K
T
YGWVNAD-
N
A
I
----
Y
I
L
L
DMC
S
S
A
A
F
I
I
LPI
L
I
GF
T
A
ARE
FGG
N
PYL
G
AT
LG
GI
L
T
---
HP
ALTNAWGV
A
AGFQTMN
-
F
F
G-F
E
I
AMIG
Y
QGT
V
F
P
V
L
LAV
W
F
M
SI
V
E
KQ
L
RRFI
P
DALDLILT
P
F
LT
V
V
I
SGF
I
A
L
L
I
IGP
A
G
R
A
L
GDG
IS
FVLST
L
IAHA
-
GWLAG
L
L
F
G
G
L
Y
SAI
V
I
TG
I
H
HSFH
A
IE
A
GLL
GN
PAI
G
VNF
L
L
P
I
W
AM
A
NV
AQG
fig|216593.1.peg.1231
Escherichia coli E2348/69 (10-342/456)
LL
PL
L
GG
K
E
NI
A
S
AA
HC
A
TRLR
L
V
L
V
D
DTLADQHA
I
G
QID
GV
K
G
C
FR
N
SG
Q
M
Q
I
IF
G
TG
V
VN
K
VYA
A
FIQVA
G
ISES
-
S
KADTARLAAQKLNPFQ---
--
RI
A
RLLSN
IF
V
P
I
IP
AI
V
AS
GLL
M
G
LLG
MV
--------
K
T
YGWVNAD-
N
A
I
----
Y
I
L
L
DMC
S
S
A
A
F
I
I
LPI
L
I
GF
T
A
ARE
FGG
N
PYL
G
AT
LG
GI
L
T
---
HP
ALTNAWGV
A
AGFQTMN
-
F
F
G-F
E
I
AMIG
Y
QGT
V
F
P
V
L
LAV
W
F
M
SI
V
E
KQ
L
RRFI
P
DALDLILT
P
F
LT
V
V
I
SGF
I
A
L
L
I
IGP
A
G
R
A
L
GDG
IS
FVLST
L
IAHA
-
GWLAG
L
L
F
G
G
L
Y
SAI
V
I
TG
I
H
HSFH
A
IE
A
GLL
GN
PAI
G
VNF
L
L
P
I
W
AM
A
NV
AQG
fig|340197.3.peg.1298
Escherichia coli F11 (10-342/456)
LL
PL
L
GG
K
E
NI
A
S
AA
HC
A
TRLR
L
V
L
V
D
DTLADQHA
I
G
QID
GV
K
G
C
FR
N
SG
Q
M
Q
I
IF
G
TG
V
VN
K
VYA
A
FIQVA
G
ISES
-
S
KADTARLAAQKLNPFQ---
--
RI
A
RLLSN
IF
V
P
I
IP
AI
V
AS
GLL
M
G
LLG
MV
--------
K
T
YGWVNAD-
N
A
I
----
Y
I
L
L
DMC
S
S
A
A
F
I
I
LPI
L
I
GF
T
A
ARE
FGG
N
PYL
G
AT
LG
GI
L
T
---
HP
ALTNAWGV
A
AGFQTMN
-
F
F
G-F
E
I
AMIG
Y
QGT
V
F
P
V
L
LAV
W
F
M
SI
V
E
KQ
L
RRFI
P
DALDLILT
P
F
LT
V
V
I
SGF
I
A
L
L
I
IGP
A
G
R
A
L
GDG
IS
FVLST
L
IAHA
-
GWLAG
L
L
F
G
G
L
Y
SAI
V
I
TG
I
H
HSFH
A
IE
A
GLL
GN
PAI
G
VNF
L
L
P
I
W
AM
A
NV
AQG
fig|340197.5.peg.1364
Escherichia coli F11 (10-342/456)
LL
PL
L
GG
K
E
NI
A
S
AA
HC
A
TRLR
L
V
L
V
D
DTLADQHA
I
G
QID
GV
K
G
C
FR
N
SG
Q
M
Q
I
IF
G
TG
V
VN
K
VYA
A
FIQVA
G
ISES
-
S
KADTARLAAQKLNPFQ---
--
RI
A
RLLSN
IF
V
P
I
IP
AI
V
AS
GLL
M
G
LLG
MV
--------
K
T
YGWVNAD-
N
A
I
----
Y
I
L
L
DMC
S
S
A
A
F
I
I
LPI
L
I
GF
T
A
ARE
FGG
N
PYL
G
AT
LG
GI
L
T
---
HP
ALTNAWGV
A
AGFQTMN
-
F
F
G-F
E
I
AMIG
Y
QGT
V
F
P
V
L
LAV
W
F
M
SI
V
E
KQ
L
RRFI
P
DALDLILT
P
F
LT
V
V
I
SGF
I
A
L
L
I
IGP
A
G
R
A
L
GDG
IS
FVLST
L
IAHA
-
GWLAG
L
L
F
G
G
L
Y
SAI
V
I
TG
I
H
HSFH
A
IE
A
GLL
GN
PAI
G
VNF
L
L
P
I
W
AM
A
NV
AQG
fig|574521.7.peg.3088
Escherichia coli O127:H6 str. E2348/69 (10-342/456)
LL
PL
L
GG
K
E
NI
A
S
AA
HC
A
TRLR
L
V
L
V
D
DTLADQHA
I
G
QID
GV
K
G
C
FR
N
SG
Q
M
Q
I
IF
G
TG
V
VN
K
VYA
A
FIQVA
G
ISES
-
S
KADTARLAAQKLNPFQ---
--
RI
A
RLLSN
IF
V
P
I
IP
AI
V
AS
GLL
M
G
LLG
MV
--------
K
T
YGWVNAD-
N
A
I
----
Y
I
L
L
DMC
S
S
A
A
F
I
I
LPI
L
I
GF
T
A
ARE
FGG
N
PYL
G
AT
LG
GI
L
T
---
HP
ALTNAWGV
A
AGFQTMN
-
F
F
G-F
E
I
AMIG
Y
QGT
V
F
P
V
L
LAV
W
F
M
SI
V
E
KQ
L
RRFI
P
DALDLILT
P
F
LT
V
V
I
SGF
I
A
L
L
I
IGP
A
G
R
A
L
GDG
IS
FVLST
L
IAHA
-
GWLAG
L
L
F
G
G
L
Y
SAI
V
I
TG
I
H
HSFH
A
IE
A
GLL
GN
PAI
G
VNF
L
L
P
I
W
AM
A
NV
AQG
fig|431946.3.peg.2687
Escherichia coli SE15 (10-342/456)
LL
PL
L
GG
K
E
NI
A
S
AA
HC
A
TRLR
L
V
L
V
D
DTLADQHA
I
G
QID
GV
K
G
C
FR
N
SG
Q
M
Q
I
IF
G
TG
V
VN
K
VYA
A
FIQVA
G
ISES
-
S
KADTARLAAQKLNPFQ---
--
RI
A
RLLSN
IF
V
P
I
IP
AI
V
AS
GLL
M
G
LLG
MV
--------
K
T
YGWVNAD-
N
A
I
----
Y
I
L
L
DMC
S
S
A
A
F
I
I
LPI
L
I
GF
T
A
ARE
FGG
N
PYL
G
AT
LG
GI
L
T
---
HP
ALTNAWGV
A
AGFQTMN
-
F
F
G-F
E
I
AMIG
Y
QGT
V
F
P
V
L
LAV
W
F
M
SI
V
E
KQ
L
RRFI
P
DALDLILT
P
F
LT
V
V
I
SGF
I
A
L
L
I
IGP
A
G
R
A
L
GDG
IS
FVLST
L
IAHA
-
GWLAG
L
L
F
G
G
L
Y
SAI
V
I
TG
I
H
HSFH
A
IE
A
GLL
GN
PAI
G
VNF
L
L
P
I
W
AM
A
NV
AQG
fig|439855.10.peg.3066
Escherichia coli SMS-3-5 (10-342/456)
LL
PL
L
GG
K
E
NI
A
S
AA
HC
A
TRLR
L
V
L
V
D
DTLADQHA
I
G
QID
GV
K
G
C
FR
N
SG
Q
M
Q
I
IF
G
TG
V
VN
K
VYA
A
FIQVA
G
ISES
-
S
KADTARLAAQKLNPFQ---
--
RI
A
RLLSN
IF
V
P
I
IP
AI
V
AS
GLL
M
G
LLG
MV
--------
K
T
YGWVNAD-
N
A
I
----
Y
I
L
L
DMC
S
S
A
A
F
I
I
LPI
L
I
GF
T
A
ARE
FGG
N
PYL
G
AT
LG
GI
L
T
---
HP
ALTNAWGV
A
AGFQTMN
-
F
F
G-F
E
I
AMIG
Y
QGT
V
F
P
V
L
LAV
W
F
M
SI
V
E
KQ
L
RRFI
P
DALDLILT
P
F
LT
V
V
I
SGF
I
A
L
L
I
IGP
A
G
R
A
L
GDG
IS
FVLST
L
IAHA
-
GWLAG
L
L
F
G
G
L
Y
SAI
V
I
TG
I
H
HSFH
A
IE
A
GLL
GN
PAI
G
VNF
L
L
P
I
W
AM
A
NV
AQG
fig|562.376.peg.3589
Escherichia coli WV_060327 (10-342/456)
LL
PL
L
GG
K
E
NI
A
S
AA
HC
A
TRLR
L
V
L
V
D
DTLADQHA
I
G
QID
GV
K
G
C
FR
N
SG
Q
M
Q
I
IF
G
TG
V
VN
K
VYA
A
FIQVA
G
ISES
-
S
KADTARLAAQKLNPFQ---
--
RI
A
RLLSN
IF
V
P
I
IP
AI
V
AS
GLL
M
G
LLG
MV
--------
K
T
YGWVNAD-
N
A
I
----
Y
I
L
L
DMC
S
S
A
A
F
I
I
LPI
L
I
GF
T
A
ARE
FGG
N
PYL
G
AT
LG
GI
L
T
---
HP
ALTNAWGV
A
AGFQTMN
-
F
F
G-F
E
I
AMIG
Y
QGT
V
F
P
V
L
LAV
W
F
M
SI
V
E
KQ
L
RRFI
P
DALDLILT
P
F
LT
V
V
I
SGF
I
A
L
L
I
IGP
A
G
R
A
L
GDG
IS
FVLST
L
IAHA
-
GWLAG
L
L
F
G
G
L
Y
SAI
V
I
TG
I
H
HSFH
A
IE
A
GLL
GN
PAI
G
VNF
L
L
P
I
W
AM
A
NV
AQG
fig|753642.3.peg.379
Escherichia coli NC101 (10-342/456)
LL
PL
L
GG
K
E
NI
A
S
AA
HC
A
TRLR
L
V
L
V
D
DTLADQHA
I
G
QID
GV
K
G
C
FR
N
SG
Q
M
Q
I
IF
G
TG
V
VN
K
VYA
A
FIQVA
G
ISES
-
S
KADTARLAAQKLNPFQ---
--
RI
A
RLLSN
IF
V
P
I
IP
AI
V
AS
GLL
M
G
LLG
MV
--------
K
T
YGWVNAD-
N
A
I
----
Y
I
L
L
DMC
S
S
A
A
F
I
I
LPI
L
I
GF
T
A
ARE
FGG
N
PYL
G
AT
LG
GI
L
T
---
HP
ALTNAWGV
A
AGFQTMN
-
F
F
G-F
E
I
AMIG
Y
QGT
I
F
P
V
L
LAV
W
F
M
SI
V
E
KQ
L
RRFI
P
DALDLILT
P
F
LT
V
V
I
SGF
I
A
L
L
I
IGP
A
G
R
A
L
GDG
IS
FVLST
L
IAHA
-
GWLAG
L
L
F
G
G
L
Y
SAI
V
I
TG
I
H
HSFH
A
IE
A
GLL
GN
PAI
G
VNF
L
L
P
I
W
AM
A
NV
AQG
fig|585057.4.peg.3070
Escherichia coli IAI39 (10-342/456)
LL
PL
L
GG
K
E
NI
T
S
AA
HC
A
TRLR
L
V
L
V
D
DTLADQHA
I
G
QID
GV
K
G
C
FR
N
SG
Q
M
Q
I
IF
G
TG
V
VN
K
VYA
A
FIQVA
G
ISES
-
S
KADTARLAAQKLNPFQ---
--
RI
A
RLLSN
IF
V
P
I
IP
AI
V
AS
GLL
M
G
LLG
MV
--------
K
T
YGWVNAD-
N
A
I
----
Y
I
L
L
DMC
S
S
A
A
F
I
I
LPI
L
I
GF
T
A
ARE
FGG
N
PYL
G
AT
LG
GI
L
T
---
HP
ALTNAWGV
A
AGFQTMN
-
F
F
G-F
E
I
AMIG
Y
QGT
V
F
P
V
L
LAV
W
F
M
SI
V
E
KQ
L
RRFI
P
DALDLILT
P
F
LT
V
V
I
SGF
I
A
L
L
I
IGP
A
G
R
A
L
GDG
IS
FVLST
L
IAHA
-
GWLAG
L
L
F
G
G
L
Y
SAI
V
I
TG
I
H
HSFH
A
IE
A
GLL
GN
PAI
G
VNF
L
L
P
I
W
AM
A
NV
AQG
fig|585057.6.peg.3076
Escherichia coli IAI39 (10-342/456)
LL
PL
L
GG
K
E
NI
T
S
AA
HC
A
TRLR
L
V
L
V
D
DTLADQHA
I
G
QID
GV
K
G
C
FR
N
SG
Q
M
Q
I
IF
G
TG
V
VN
K
VYA
A
FIQVA
G
ISES
-
S
KADTARLAAQKLNPFQ---
--
RI
A
RLLSN
IF
V
P
I
IP
AI
V
AS
GLL
M
G
LLG
MV
--------
K
T
YGWVNAD-
N
A
I
----
Y
I
L
L
DMC
S
S
A
A
F
I
I
LPI
L
I
GF
T
A
ARE
FGG
N
PYL
G
AT
LG
GI
L
T
---
HP
ALTNAWGV
A
AGFQTMN
-
F
F
G-F
E
I
AMIG
Y
QGT
V
F
P
V
L
LAV
W
F
M
SI
V
E
KQ
L
RRFI
P
DALDLILT
P
F
LT
V
V
I
SGF
I
A
L
L
I
IGP
A
G
R
A
L
GDG
IS
FVLST
L
IAHA
-
GWLAG
L
L
F
G
G
L
Y
SAI
V
I
TG
I
H
HSFH
A
IE
A
GLL
GN
PAI
G
VNF
L
L
P
I
W
AM
A
NV
AQG
fig|656408.3.peg.4181
Escherichia coli H591 (7-336/625)
K
I
V
AG
VGG
A
D
NI
V
S
LM
HC
A
TRLRF
K
L
K
D
ESKAQAEV
L
K
KTP
G
I
I
M
V
VE
S
GG
Q
F
QVVIG
NH
V
AD
-
VFL
A
VNSVA
G
LDE-
-
-
KAQQAPENDDKGNLLN---
--
RF
V
YVISG
IF
T
PLI
G
LM
A
AT
G
I
L
K
G
MLA
L
A
--------
L
T
FQWTTEQ-
S
G
T
----
Y
L
I
L
FSA
S
D
A
L
F
W
F
F
PI
I
L
GY
T
A
AKR
FGG
N
PFT
A
MV
I
G
GA
LV
---
HP
LILTAFEN
G
QKADELG
L
DF
LGI
P
V
TLLN
Y
SSS
VIP
I
I
FSA
W
L
C
SI
L
E
RR
L
NAWL
P
SAIKNFFT
PL
LC
L
MV
ITP
VT
F
LL
V
GP
L
S
T
WI
SEL
I
A
AGYLW
L
YQAV
-
PAFAG
AV
M
G
G
F
W
QIF
VM
F
G
L
H
WGLV
P
LC
I
NNF
--
TVL
G
YDT
M
I
PLL
MP
A
IM
AQ
fig|679206.4.peg.4051
Escherichia coli MS 119-7 (7-336/625)
K
I
V
AG
VGG
A
D
NI
V
S
LM
HC
A
TRLRF
K
L
K
D
ESKAQAEV
L
K
KTP
G
I
I
M
V
VE
S
GG
Q
F
QVVIG
NH
V
AD
-
VFL
A
VNSVA
G
LDE-
-
-
KAQQAPENDDKGNLLN---
--
RF
V
YVISG
IF
T
PLI
G
LM
A
AT
G
I
L
K
G
MLA
L
A
--------
L
T
FQWTTEQ-
S
G
T
----
Y
L
I
L
FSA
S
D
A
L
F
W
F
F
PI
I
L
GY
T
A
AKR
FGG
N
PFT
A
MV
I
G
GA
LV
---
HP
LILTAFEN
G
QKADELG
L
DF
LGI
P
V
TLLN
Y
SSS
VIP
I
I
FSA
W
L
C
SI
L
E
RR
L
NAWL
P
SAIKNFFT
PL
LC
L
MV
ITP
VT
F
LL
V
GP
L
S
T
WI
SEL
I
A
AGYLW
L
YQAV
-
PAFAG
AV
M
G
G
F
W
QIF
VM
F
G
L
H
WGLV
P
LC
I
NNF
--
TVL
G
YDT
M
I
PLL
MP
A
IM
AQ
fig|656443.3.peg.4663
Escherichia coli TA271 (7-336/625)
K
I
V
AG
VGG
A
D
NI
V
S
LM
HC
A
TRLRF
K
L
K
D
ESKAQAEV
L
K
KTP
G
I
I
M
V
VE
S
GG
Q
F
QVVIG
NH
V
AD
-
VFL
A
VNSVA
G
LDE-
-
-
KAQQAPENDDKGNLLN---
--
RF
V
YVISG
IF
T
PLI
G
LM
A
AT
G
I
L
K
G
MLA
L
A
--------
L
T
FQWTTEQ-
S
G
T
----
Y
L
I
L
FSA
S
D
A
L
F
W
F
F
PI
I
L
GY
T
A
AKR
FGG
N
PFT
A
MV
I
G
GA
LV
---
HP
LILTAFEN
G
QKADELG
L
DF
LGI
P
V
TLLN
Y
SSS
VIP
I
I
FSA
W
L
C
SI
L
E
RR
L
NAWL
P
SAIKNFFT
PL
LC
L
MV
ITP
VT
F
LL
V
GP
L
S
T
WI
SEL
I
A
AGYLW
L
YQAV
-
PAFAG
AV
M
G
G
F
W
QIF
VM
F
G
L
H
WGLV
P
LC
I
NNF
--
TVL
G
YDT
M
I
PLL
MP
A
IM
AQ
fig|585396.4.peg.4711
Escherichia coli O111:H- str. 11128 (7-336/446)
K
I
V
AG
VGG
A
D
NI
V
S
LM
HC
A
TRLRF
K
L
K
D
ESKAQAEV
L
K
KTP
G
I
I
M
V
VE
S
GG
Q
F
QVVIG
NH
V
AD
-
VFL
A
VNSVA
G
LGE-
-
-
KAQQAPENDEKGNLLN---
--
RF
V
YVISG
IF
T
PLI
G
LM
A
AT
G
I
L
K
G
MLA
L
A
--------
L
T
FQWTTEQ-
S
G
T
----
Y
L
I
L
FSA
S
D
A
L
F
W
F
F
PI
I
L
GY
T
A
GKR
FGG
N
PFT
A
MV
I
G
GA
LV
---
HP
LILTAFEN
G
QKADELG
L
DF
LGI
P
V
TLLN
Y
SSS
VIP
I
I
FSA
W
L
C
SI
L
E
RR
L
NAWL
P
SAIKNFFT
PL
LC
L
MV
ITP
VT
F
LL
V
GP
L
S
T
WI
SEL
I
A
AGYLW
L
YQAV
-
PAFAG
AV
M
G
G
F
W
QIF
VM
F
G
L
H
WGLV
P
LC
I
NNF
--
TVL
G
YDT
M
I
PLL
MP
A
IM
AQ
fig|1040638.4.peg.1609
Escherichia coli O104:H4 str. LB226692 (7-336/625)
K
I
V
AG
VGG
A
D
NI
V
S
LM
HC
A
TRLRF
K
L
K
D
ESKAQAEV
L
K
KTP
G
I
I
M
V
VE
S
GG
Q
F
QVVIG
NH
V
AD
-
VFL
A
VNSVA
G
LGE-
-
-
KAQQAPENDEKGNLLN---
--
RF
V
YVISG
IF
T
PLI
G
LM
A
AT
G
I
L
K
G
MLA
L
A
--------
L
T
FQWTTEQ-
S
G
T
----
Y
L
I
L
FSA
S
D
A
L
F
W
F
F
PI
I
L
GY
T
A
GKR
FGG
N
PFT
A
MV
I
G
GA
LV
---
HP
LILTAFEN
G
QKADELG
L
DF
LGI
P
V
TLLN
Y
SSS
VIP
I
I
FSA
W
L
C
SI
L
E
RR
L
NAWL
P
SAIKNFFT
PL
LC
L
MV
ITP
VT
F
LL
V
GP
L
S
T
WI
SEL
I
A
AGYLW
L
YQAV
-
PAFAG
AV
M
G
G
F
W
QIF
VM
F
G
L
H
WGLV
P
LC
I
NNF
--
TVL
G
YDT
M
I
PLL
MP
A
IM
AQ
fig|6666666.5357.peg.3354
Escherichia coli TY-2482 (7-336/625)
K
I
V
AG
VGG
A
D
NI
V
S
LM
HC
A
TRLRF
K
L
K
D
ESKAQAEV
L
K
KTP
G
I
I
M
V
VE
S
GG
Q
F
QVVIG
NH
V
AD
-
VFL
A
VNSVA
G
LGE-
-
-
KAQQAPENDEKGNLLN---
--
RF
V
YVISG
IF
T
PLI
G
LM
A
AT
G
I
L
K
G
MLA
L
A
--------
L
T
FQWTTEQ-
S
G
T
----
Y
L
I
L
FSA
S
D
A
L
F
W
F
F
PI
I
L
GY
T
A
GKR
FGG
N
PFT
A
MV
I
G
GA
LV
---
HP
LILTAFEN
G
QKADELG
L
DF
LGI
P
V
TLLN
Y
SSS
VIP
I
I
FSA
W
L
C
SI
L
E
RR
L
NAWL
P
SAIKNFFT
PL
LC
L
MV
ITP
VT
F
LL
V
GP
L
S
T
WI
SEL
I
A
AGYLW
L
YQAV
-
PAFAG
AV
M
G
G
F
W
QIF
VM
F
G
L
H
WGLV
P
LC
I
NNF
--
TVL
G
YDT
M
I
PLL
MP
A
IM
AQ
fig|585055.6.peg.4223
Escherichia coli 55989 (7-336/625)
K
I
V
AG
VGG
A
D
NI
V
S
LM
HC
A
TRLRF
K
L
K
D
ESKAQAEV
L
K
KTP
G
I
I
M
V
VE
S
GG
Q
F
QVVIG
NH
V
AD
-
VFL
A
VNSVA
G
LGE-
-
-
KAQQAPENDEKGNLLN---
--
RF
V
YVISG
IF
T
PLI
G
LM
A
AT
G
I
L
K
G
MLA
L
A
--------
L
T
FQWTTEQ-
S
G
T
----
Y
L
I
L
FSA
S
D
A
L
F
W
F
F
PI
I
L
GY
T
A
GKR
FGG
N
PFT
A
MV
I
G
GA
LV
---
HP
LILTAFEN
G
QKADELG
L
DF
LGI
P
V
TLLN
Y
SSS
VIP
I
I
FSA
W
L
C
SI
L
E
RR
L
NAWL
P
SAIKNFFT
PL
LC
L
MV
ITP
VT
F
LL
V
GP
L
S
T
WI
SEL
I
A
AGYLW
L
YQAV
-
PAFAG
AV
M
G
G
F
W
QIF
VM
F
G
L
H
WGLV
P
LC
I
NNF
--
TVL
G
YDT
M
I
PLL
MP
A
IM
AQ
fig|585055.8.peg.4226
Escherichia coli 55989 (7-336/625)
K
I
V
AG
VGG
A
D
NI
V
S
LM
HC
A
TRLRF
K
L
K
D
ESKAQAEV
L
K
KTP
G
I
I
M
V
VE
S
GG
Q
F
QVVIG
NH
V
AD
-
VFL
A
VNSVA
G
LGE-
-
-
KAQQAPENDEKGNLLN---
--
RF
V
YVISG
IF
T
PLI
G
LM
A
AT
G
I
L
K
G
MLA
L
A
--------
L
T
FQWTTEQ-
S
G
T
----
Y
L
I
L
FSA
S
D
A
L
F
W
F
F
PI
I
L
GY
T
A
GKR
FGG
N
PFT
A
MV
I
G
GA
LV
---
HP
LILTAFEN
G
QKADELG
L
DF
LGI
P
V
TLLN
Y
SSS
VIP
I
I
FSA
W
L
C
SI
L
E
RR
L
NAWL
P
SAIKNFFT
PL
LC
L
MV
ITP
VT
F
LL
V
GP
L
S
T
WI
SEL
I
A
AGYLW
L
YQAV
-
PAFAG
AV
M
G
G
F
W
QIF
VM
F
G
L
H
WGLV
P
LC
I
NNF
--
TVL
G
YDT
M
I
PLL
MP
A
IM
AQ
fig|340184.3.peg.845
Escherichia coli B7A (7-336/625)
K
I
V
AG
VGG
A
D
NI
V
S
LM
HC
A
TRLRF
K
L
K
D
ESKAQAEV
L
K
KTP
G
I
I
M
V
VE
S
GG
Q
F
QVVIG
NH
V
AD
-
VFL
A
VNSVA
G
LGE-
-
-
KAQQAPENDEKGNLLN---
--
RF
V
YVISG
IF
T
PLI
G
LM
A
AT
G
I
L
K
G
MLA
L
A
--------
L
T
FQWTTEQ-
S
G
T
----
Y
L
I
L
FSA
S
D
A
L
F
W
F
F
PI
I
L
GY
T
A
GKR
FGG
N
PFT
A
MV
I
G
GA
LV
---
HP
LILTAFEN
G
QKADELG
L
DF
LGI
P
V
TLLN
Y
SSS
VIP
I
I
FSA
W
L
C
SI
L
E
RR
L
NAWL
P
SAIKNFFT
PL
LC
L
MV
ITP
VT
F
LL
V
GP
L
S
T
WI
SEL
I
A
AGYLW
L
YQAV
-
PAFAG
AV
M
G
G
F
W
QIF
VM
F
G
L
H
WGLV
P
LC
I
NNF
--
TVL
G
YDT
M
I
PLL
MP
A
IM
AQ
fig|340184.6.peg.878
Escherichia coli B7A (7-336/625)
K
I
V
AG
VGG
A
D
NI
V
S
LM
HC
A
TRLRF
K
L
K
D
ESKAQAEV
L
K
KTP
G
I
I
M
V
VE
S
GG
Q
F
QVVIG
NH
V
AD
-
VFL
A
VNSVA
G
LGE-
-
-
KAQQAPENDEKGNLLN---
--
RF
V
YVISG
IF
T
PLI
G
LM
A
AT
G
I
L
K
G
MLA
L
A
--------
L
T
FQWTTEQ-
S
G
T
----
Y
L
I
L
FSA
S
D
A
L
F
W
F
F
PI
I
L
GY
T
A
GKR
FGG
N
PFT
A
MV
I
G
GA
LV
---
HP
LILTAFEN
G
QKADELG
L
DF
LGI
P
V
TLLN
Y
SSS
VIP
I
I
FSA
W
L
C
SI
L
E
RR
L
NAWL
P
SAIKNFFT
PL
LC
L
MV
ITP
VT
F
LL
V
GP
L
S
T
WI
SEL
I
A
AGYLW
L
YQAV
-
PAFAG
AV
M
G
G
F
W
QIF
VM
F
G
L
H
WGLV
P
LC
I
NNF
--
TVL
G
YDT
M
I
PLL
MP
A
IM
AQ
fig|595495.4.peg.2733
Escherichia coli KO11 (7-336/625)
K
I
V
AG
VGG
A
D
NI
V
S
LM
HC
A
TRLRF
K
L
K
D
ESKAQAEV
L
K
KTP
G
I
I
M
V
VE
S
GG
Q
F
QVVIG
NH
V
AD
-
VFL
A
VNSVA
G
LGE-
-
-
KAQQAPENDEKGNLLN---
--
RF
V
YVISG
IF
T
PLI
G
LM
A
AT
G
I
L
K
G
MLA
L
A
--------
L
T
FQWTTEQ-
S
G
T
----
Y
L
I
L
FSA
S
D
A
L
F
W
F
F
PI
I
L
GY
T
A
GKR
FGG
N
PFT
A
MV
I
G
GA
LV
---
HP
LILTAFEN
G
QKADELG
L
DF
LGI
P
V
TLLN
Y
SSS
VIP
I
I
FSA
W
L
C
SI
L
E
RR
L
NAWL
P
SAIKNFFT
PL
LC
L
MV
ITP
VT
F
LL
V
GP
L
S
T
WI
SEL
I
A
AGYLW
L
YQAV
-
PAFAG
AV
M
G
G
F
W
QIF
VM
F
G
L
H
WGLV
P
LC
I
NNF
--
TVL
G
YDT
M
I
PLL
MP
A
IM
AQ
fig|679204.3.peg.2860
Escherichia coli MS 145-7 (7-336/625)
K
I
V
AG
VGG
A
D
NI
V
S
LM
HC
A
TRLRF
K
L
K
D
ESKAQAEV
L
K
KTP
G
I
I
M
V
VE
S
GG
Q
F
QVVIG
NH
V
AD
-
VFL
A
VNSVA
G
LGE-
-
-
KAQQAPENDEKGNLLN---
--
RF
V
YVISG
IF
T
PLI
G
LM
A
AT
G
I
L
K
G
MLA
L
A
--------
L
T
FQWTTEQ-
S
G
T
----
Y
L
I
L
FSA
S
D
A
L
F
W
F
F
PI
I
L
GY
T
A
GKR
FGG
N
PFT
A
MV
I
G
GA
LV
---
HP
LILTAFEN
G
QKADELG
L
DF
LGI
P
V
TLLN
Y
SSS
VIP
I
I
FSA
W
L
C
SI
L
E
RR
L
NAWL
P
SAIKNFFT
PL
LC
L
MV
ITP
VT
F
LL
V
GP
L
S
T
WI
SEL
I
A
AGYLW
L
YQAV
-
PAFAG
AV
M
G
G
F
W
QIF
VM
F
G
L
H
WGLV
P
LC
I
NNF
--
TVL
G
YDT
M
I
PLL
MP
A
IM
AQ
fig|749532.3.peg.108
Escherichia coli MS 78-1 (7-336/625)
K
I
V
AG
VGG
A
D
NI
V
S
LM
HC
A
TRLRF
K
L
K
D
ESKAQAEV
L
K
KTP
G
I
I
M
V
VE
S
GG
Q
F
QVVIG
NH
V
AD
-
VFL
A
VNSVA
G
LGE-
-
-
KAQQAPENDEKGNLLN---
--
RF
V
YVISG
IF
T
PLI
G
LM
A
AT
G
I
L
K
G
MLA
L
A
--------
L
T
FQWTTEQ-
S
G
T
----
Y
L
I
L
FSA
S
D
A
L
F
W
F
F
PI
I
L
GY
T
A
GKR
FGG
N
PFT
A
MV
I
G
GA
LV
---
HP
LILTAFEN
G
QKADELG
L
DF
LGI
P
V
TLLN
Y
SSS
VIP
I
I
FSA
W
L
C
SI
L
E
RR
L
NAWL
P
SAIKNFFT
PL
LC
L
MV
ITP
VT
F
LL
V
GP
L
S
T
WI
SEL
I
A
AGYLW
L
YQAV
-
PAFAG
AV
M
G
G
F
W
QIF
VM
F
G
L
H
WGLV
P
LC
I
NNF
--
TVL
G
YDT
M
I
PLL
MP
A
IM
AQ
fig|573235.3.peg.5006
Escherichia coli O26:H11 str. 11368 (7-336/625)
K
I
V
AG
VGG
A
D
NI
V
S
LM
HC
A
TRLRF
K
L
K
D
ESKAQAEV
L
K
KTP
G
I
I
M
V
VE
S
GG
Q
F
QVVIG
NH
V
AD
-
VFL
A
VNSVA
G
LGE-
-
-
KAQQAPENDEKGNLLN---
--
RF
V
YVISG
IF
T
PLI
G
LM
A
AT
G
I
L
K
G
MLA
L
A
--------
L
T
FQWTTEQ-
S
G
T
----
Y
L
I
L
FSA
S
D
A
L
F
W
F
F
PI
I
L
GY
T
A
GKR
FGG
N
PFT
A
MV
I
G
GA
LV
---
HP
LILTAFEN
G
QKADELG
L
DF
LGI
P
V
TLLN
Y
SSS
VIP
I
I
FSA
W
L
C
SI
L
E
RR
L
NAWL
P
SAIKNFFT
PL
LC
L
MV
ITP
VT
F
LL
V
GP
L
S
T
WI
SEL
I
A
AGYLW
L
YQAV
-
PAFAG
AV
M
G
G
F
W
QIF
VM
F
G
L
H
WGLV
P
LC
I
NNF
--
TVL
G
YDT
M
I
PLL
MP
A
IM
AQ
fig|566546.3.peg.3272
Escherichia coli W (7-336/625)
K
I
V
AG
VGG
A
D
NI
V
S
LM
HC
A
TRLRF
K
L
K
D
ESKAQAEV
L
K
KTP
G
I
I
M
V
VE
S
GG
Q
F
QVVIG
NH
V
AD
-
VFL
A
VNSVA
G
LGE-
-
-
KAQQAPENDEKGNLLN---
--
RF
V
YVISG
IF
T
PLI
G
LM
A
AT
G
I
L
K
G
MLA
L
A
--------
L
T
FQWTTEQ-
S
G
T
----
Y
L
I
L
FSA
S
D
A
L
F
W
F
F
PI
I
L
GY
T
A
GKR
FGG
N
PFT
A
MV
I
G
GA
LV
---
HP
LILTAFEN
G
QKADELG
L
DF
LGI
P
V
TLLN
Y
SSS
VIP
I
I
FSA
W
L
C
SI
L
E
RR
L
NAWL
P
SAIKNFFT
PL
LC
L
MV
ITP
VT
F
LL
V
GP
L
S
T
WI
SEL
I
A
AGYLW
L
YQAV
-
PAFAG
AV
M
G
G
F
W
QIF
VM
F
G
L
H
WGLV
P
LC
I
NNF
--
TVL
G
YDT
M
I
PLL
MP
A
IM
AQ
fig|566546.4.peg.3977
Escherichia coli W (7-336/625)
K
I
V
AG
VGG
A
D
NI
V
S
LM
HC
A
TRLRF
K
L
K
D
ESKAQAEV
L
K
KTP
G
I
I
M
V
VE
S
GG
Q
F
QVVIG
NH
V
AD
-
VFL
A
VNSVA
G
LGE-
-
-
KAQQAPENDEKGNLLN---
--
RF
V
YVISG
IF
T
PLI
G
LM
A
AT
G
I
L
K
G
MLA
L
A
--------
L
T
FQWTTEQ-
S
G
T
----
Y
L
I
L
FSA
S
D
A
L
F
W
F
F
PI
I
L
GY
T
A
GKR
FGG
N
PFT
A
MV
I
G
GA
LV
---
HP
LILTAFEN
G
QKADELG
L
DF
LGI
P
V
TLLN
Y
SSS
VIP
I
I
FSA
W
L
C
SI
L
E
RR
L
NAWL
P
SAIKNFFT
PL
LC
L
MV
ITP
VT
F
LL
V
GP
L
S
T
WI
SEL
I
A
AGYLW
L
YQAV
-
PAFAG
AV
M
G
G
F
W
QIF
VM
F
G
L
H
WGLV
P
LC
I
NNF
--
TVL
G
YDT
M
I
PLL
MP
A
IM
AQ
fig|344601.3.peg.2390
Escherichia coli B171 (7-336/625)
K
I
V
AG
VGG
A
D
NI
V
S
LM
HC
A
TRLRF
K
L
K
D
ESKAQAEV
L
K
KTP
G
I
I
M
V
VE
S
GG
Q
F
QVVIG
NH
V
AD
-
VFL
A
VNSVA
G
LDE-
-
-
KAQQAPENDDKSNLLN---
--
RF
V
YVISG
IF
T
PLI
G
LM
A
AT
G
I
L
K
G
MLA
L
A
--------
L
T
FQWTTEQ-
S
G
T
----
Y
L
I
L
FSA
S
D
A
L
F
W
F
F
PI
I
L
GY
T
A
GKR
FGG
N
PFT
A
MV
I
G
GA
LV
---
HP
LILTAFEN
G
QKADELG
L
DF
LGI
P
V
TLLN
Y
SSS
VIP
I
I
FSA
W
L
C
SI
L
E
RR
L
NAWL
P
SAIKNFFT
PL
LC
L
MV
ITP
VT
F
LL
V
GP
L
S
T
WI
SEM
I
A
AGYLW
L
YQAV
-
PAFAG
AV
M
G
G
F
W
QIF
VM
F
G
L
H
WGLV
P
LC
I
NNF
--
TVL
G
YDT
M
I
PLL
MP
A
IM
AQ
fig|344601.5.peg.2493
Escherichia coli B171 (7-336/625)
K
I
V
AG
VGG
A
D
NI
V
S
LM
HC
A
TRLRF
K
L
K
D
ESKAQAEV
L
K
KTP
G
I
I
M
V
VE
S
GG
Q
F
QVVIG
NH
V
AD
-
VFL
A
VNSVA
G
LDE-
-
-
KAQQAPENDDKSNLLN---
--
RF
V
YVISG
IF
T
PLI
G
LM
A
AT
G
I
L
K
G
MLA
L
A
--------
L
T
FQWTTEQ-
S
G
T
----
Y
L
I
L
FSA
S
D
A
L
F
W
F
F
PI
I
L
GY
T
A
GKR
FGG
N
PFT
A
MV
I
G
GA
LV
---
HP
LILTAFEN
G
QKADELG
L
DF
LGI
P
V
TLLN
Y
SSS
VIP
I
I
FSA
W
L
C
SI
L
E
RR
L
NAWL
P
SAIKNFFT
PL
LC
L
MV
ITP
VT
F
LL
V
GP
L
S
T
WI
SEM
I
A
AGYLW
L
YQAV
-
PAFAG
AV
M
G
G
F
W
QIF
VM
F
G
L
H
WGLV
P
LC
I
NNF
--
TVL
G
YDT
M
I
PLL
MP
A
IM
AQ
fig|749545.3.peg.3457
Escherichia coli MS 182-1 (7-336/625)
K
I
V
AG
VGG
A
D
NI
V
S
LM
HC
A
TRLRF
K
L
K
D
ESKAQAEV
L
K
KTP
G
I
I
M
V
VE
S
GG
Q
F
QVVIG
NH
V
AD
-
VFL
A
VNSVA
G
LGE-
-
-
KAQQAPENDEKGNLLN---
--
RF
V
YVISG
IF
T
PLI
G
LM
A
AT
G
I
L
K
G
MLA
L
A
--------
L
T
FQWTTEQ-
S
G
T
----
Y
L
I
L
FSA
S
D
A
L
F
W
F
F
PI
I
L
GY
T
A
GKR
FGG
N
PFT
A
MV
I
G
GA
LV
---
HP
LILTAFEN
G
QKADELG
L
DF
LGI
P
V
TLLN
Y
SSS
VIP
I
I
FSA
W
L
C
SI
L
E
RR
L
NVWL
P
SAIKNFFT
PL
LC
L
MV
ITP
VT
F
LL
V
GP
L
S
T
WI
SEL
I
A
AGYLW
L
YQAV
-
PAFAG
AV
M
G
G
F
W
QIF
VM
F
G
L
H
WGLV
P
LC
I
NNF
--
TVL
G
YDT
M
I
PLL
MP
A
IM
AQ
fig|550672.3.peg.3797
Escherichia coli B088 (7-336/625)
K
I
V
AG
VGG
A
D
NI
V
S
LM
HC
A
TRLRF
K
L
K
D
ESKAQAEV
L
K
NTP
G
I
I
M
V
VE
S
GG
Q
F
QVVIG
NH
V
AD
-
VFL
A
VNSVA
G
LGE-
-
-
KAQQAPENDEKGNLLN---
--
RF
V
YVISG
IF
T
PLI
G
LM
A
AT
G
I
L
K
G
MLA
L
A
--------
L
T
FQWTTEQ-
S
G
T
----
Y
L
I
L
FSA
S
D
A
L
F
W
F
F
PI
I
L
GY
T
A
GKR
FGG
N
PFT
A
MV
I
G
GA
LV
---
HP
LILTAFEN
G
QKADELG
L
DF
LGI
P
V
TLLN
Y
SSS
VIP
I
I
FSA
W
L
C
SI
L
E
RR
L
NAWL
P
SAIKNFFT
PL
LC
L
MV
ITP
VT
F
LL
V
GP
L
S
T
WI
SEL
I
A
AGYLW
L
YQAV
-
PAFAG
AV
M
G
G
F
W
QIF
VM
F
G
L
H
WGLV
P
LC
I
NNF
--
TVL
G
YDT
M
I
PLL
MP
A
IM
AQ
fig|331111.12.peg.4469
Escherichia coli E24377A (7-336/625)
K
I
V
AG
VGG
A
D
NI
V
S
LM
HC
A
TRLRF
K
L
K
D
ESKAQAEV
L
K
NTP
G
I
I
M
V
VE
S
GG
Q
F
QVVIG
NH
V
AD
-
VFL
A
VNSVA
G
LGE-
-
-
KAQQAPENDEKGNLLN---
--
RF
V
YVISG
IF
T
PLI
G
LM
A
AT
G
I
L
K
G
MLA
L
A
--------
L
T
FQWTTEQ-
S
G
T
----
Y
L
I
L
FSA
S
D
A
L
F
W
F
F
PI
I
L
GY
T
A
GKR
FGG
N
PFT
A
MV
I
G
GA
LV
---
HP
LILTAFEN
G
QKADELG
L
DF
LGI
P
V
TLLN
Y
SSS
VIP
I
I
FSA
W
L
C
SI
L
E
RR
L
NAWL
P
SAIKNFFT
PL
LC
L
MV
ITP
VT
F
LL
V
GP
L
S
T
WI
SEL
I
A
AGYLW
L
YQAV
-
PAFAG
AV
M
G
G
F
W
QIF
VM
F
G
L
H
WGLV
P
LC
I
NNF
--
TVL
G
YDT
M
I
PLL
MP
A
IM
AQ
fig|331111.3.peg.1871
Escherichia coli E24377A (7-336/625)
K
I
V
AG
VGG
A
D
NI
V
S
LM
HC
A
TRLRF
K
L
K
D
ESKAQAEV
L
K
NTP
G
I
I
M
V
VE
S
GG
Q
F
QVVIG
NH
V
AD
-
VFL
A
VNSVA
G
LGE-
-
-
KAQQAPENDEKGNLLN---
--
RF
V
YVISG
IF
T
PLI
G
LM
A
AT
G
I
L
K
G
MLA
L
A
--------
L
T
FQWTTEQ-
S
G
T
----
Y
L
I
L
FSA
S
D
A
L
F
W
F
F
PI
I
L
GY
T
A
GKR
FGG
N
PFT
A
MV
I
G
GA
LV
---
HP
LILTAFEN
G
QKADELG
L
DF
LGI
P
V
TLLN
Y
SSS
VIP
I
I
FSA
W
L
C
SI
L
E
RR
L
NAWL
P
SAIKNFFT
PL
LC
L
MV
ITP
VT
F
LL
V
GP
L
S
T
WI
SEL
I
A
AGYLW
L
YQAV
-
PAFAG
AV
M
G
G
F
W
QIF
VM
F
G
L
H
WGLV
P
LC
I
NNF
--
TVL
G
YDT
M
I
PLL
MP
A
IM
AQ
fig|562.375.peg.270
Escherichia coli EC4100B (7-336/625)
K
I
V
AG
VGG
A
D
NI
V
S
LM
HC
A
TRLRF
K
L
K
D
ESKAQAEV
L
K
NTP
G
I
I
M
V
VE
S
GG
Q
F
QVVIG
NH
V
AD
-
VFL
A
VNSVA
G
LGE-
-
-
KAQQAPENDEKGNLLN---
--
RF
V
YVISG
IF
T
PLI
G
LM
A
AT
G
I
L
K
G
MLA
L
A
--------
L
T
FQWTTEQ-
S
G
T
----
Y
L
I
L
FSA
S
D
A
L
F
W
F
F
PI
I
L
GY
T
A
GKR
FGG
N
PFT
A
MV
I
G
GA
LV
---
HP
LILTAFEN
G
QKADELG
L
DF
LGI
P
V
TLLN
Y
SSS
VIP
I
I
FSA
W
L
C
SI
L
E
RR
L
NAWL
P
SAIKNFFT
PL
LC
L
MV
ITP
VT
F
LL
V
GP
L
S
T
WI
SEL
I
A
AGYLW
L
YQAV
-
PAFAG
AV
M
G
G
F
W
QIF
VM
F
G
L
H
WGLV
P
LC
I
NNF
--
TVL
G
YDT
M
I
PLL
MP
A
IM
AQ
fig|679207.4.peg.44
Escherichia coli MS 107-1 (7-336/625)
K
I
V
AG
VGG
A
D
NI
V
S
LM
HC
A
TRLRF
K
L
K
D
ESKAQAEV
L
K
NTP
G
I
I
M
V
VE
S
GG
Q
F
QVVIG
NH
V
AD
-
VFL
A
VNSVA
G
LGE-
-
-
KAQQAPENDEKGNLLN---
--
RF
V
YVISG
IF
T
PLI
G
LM
A
AT
G
I
L
K
G
MLA
L
A
--------
L
T
FQWTTEQ-
S
G
T
----
Y
L
I
L
FSA
S
D
A
L
F
W
F
F
PI
I
L
GY
T
A
GKR
FGG
N
PFT
A
MV
I
G
GA
LV
---
HP
LILTAFEN
G
QKADELG
L
DF
LGI
P
V
TLLN
Y
SSS
VIP
I
I
FSA
W
L
C
SI
L
E
RR
L
NAWL
P
SAIKNFFT
PL
LC
L
MV
ITP
VT
F
LL
V
GP
L
S
T
WI
SEL
I
A
AGYLW
L
YQAV
-
PAFAG
AV
M
G
G
F
W
QIF
VM
F
G
L
H
WGLV
P
LC
I
NNF
--
TVL
G
YDT
M
I
PLL
MP
A
IM
AQ
fig|340185.3.peg.2200
Escherichia coli E22 (7-336/625)
K
I
V
AG
VGG
A
D
NI
V
S
LM
HC
A
TRLRF
K
L
K
D
ESKAQAEV
L
K
KTP
G
I
I
M
V
VE
S
GG
Q
F
QVVIG
NH
V
AD
-
VFL
A
VNSVA
G
LDE-
-
-
KAQQAPENDDKGNLLN---
--
RF
V
YVISG
IF
T
PLI
G
LM
A
AT
G
I
L
K
G
MLA
L
A
--------
L
T
FQWTTEQ-
S
G
T
----
Y
L
I
L
FSA
S
D
A
L
F
W
F
F
PI
I
L
GY
T
A
GKR
FGG
N
PFT
A
MV
I
G
GA
LV
---
HP
LILTAFEN
G
QKADELG
L
DF
LGI
P
V
TLLN
Y
SSS
VIP
I
I
FSA
W
L
C
SI
L
E
RR
L
NAWL
P
SAIKNFFT
PL
LC
L
MV
ITP
VT
F
LL
V
GP
L
S
T
WI
SEM
I
A
AGYLW
L
YQAV
-
PAFAG
AV
M
G
G
F
W
QIF
VM
F
G
L
H
WGLV
P
LC
I
NNF
--
TVL
G
YDT
M
I
PLL
MP
A
IM
AQ
fig|340185.4.peg.2329
Escherichia coli E22 (7-336/625)
K
I
V
AG
VGG
A
D
NI
V
S
LM
HC
A
TRLRF
K
L
K
D
ESKAQAEV
L
K
KTP
G
I
I
M
V
VE
S
GG
Q
F
QVVIG
NH
V
AD
-
VFL
A
VNSVA
G
LDE-
-
-
KAQQAPENDDKGNLLN---
--
RF
V
YVISG
IF
T
PLI
G
LM
A
AT
G
I
L
K
G
MLA
L
A
--------
L
T
FQWTTEQ-
S
G
T
----
Y
L
I
L
FSA
S
D
A
L
F
W
F
F
PI
I
L
GY
T
A
GKR
FGG
N
PFT
A
MV
I
G
GA
LV
---
HP
LILTAFEN
G
QKADELG
L
DF
LGI
P
V
TLLN
Y
SSS
VIP
I
I
FSA
W
L
C
SI
L
E
RR
L
NAWL
P
SAIKNFFT
PL
LC
L
MV
ITP
VT
F
LL
V
GP
L
S
T
WI
SEM
I
A
AGYLW
L
YQAV
-
PAFAG
AV
M
G
G
F
W
QIF
VM
F
G
L
H
WGLV
P
LC
I
NNF
--
TVL
G
YDT
M
I
PLL
MP
A
IM
AQ
fig|585395.4.peg.4643
Escherichia coli O103:H2 str. 12009 (7-336/625)
K
I
V
AG
VGG
A
D
NI
V
S
LM
HC
A
TRLRF
K
L
K
D
ESKAQAEV
L
K
KTP
G
I
I
M
V
VE
S
GG
Q
F
QVVIG
NH
V
AD
-
VFL
A
VNSVA
G
LDE-
-
-
KAQQAPENDDKGNLLN---
--
RF
V
YVISG
IF
T
PLI
G
LM
A
AT
G
I
L
K
G
MLA
L
A
--------
L
T
FQWTTEQ-
S
G
T
----
Y
L
I
L
FSA
S
D
A
L
F
W
F
F
PI
I
L
GY
T
A
GKR
FGG
N
PFT
A
MV
I
G
GA
LV
---
HP
LILTAFEN
G
QKADELG
L
DF
LGI
P
V
TLLN
Y
SSS
VIP
I
I
FSA
W
L
C
SI
L
E
RR
L
NAWL
P
SAIKNFFT
PL
LC
L
MV
ITP
VT
F
LL
V
GP
L
S
T
WI
SEM
I
A
AGYLW
L
YQAV
-
PAFAG
AV
M
G
G
F
W
QIF
VM
F
G
L
H
WGLV
P
LC
I
NNF
--
TVL
G
YDT
M
I
PLL
MP
A
IM
AQ
fig|753642.3.peg.4199
Escherichia coli NC101 (12-336/624)
VGG
A
D
NI
V
S
LM
HC
A
TRLRF
K
L
K
D
ESKAQAEV
L
K
KTP
G
I
I
M
V
VE
S
GG
Q
F
QVVIG
NH
V
AD
-
VFL
A
VNSVA
G
LGE-
-
-
KAQQAPENDDKDNLLN---
--
RF
V
YVISG
IF
T
PLI
G
LM
A
AT
G
I
L
K
G
MLA
L
A
--------
L
T
FQWTTEQ-
S
G
T
----
Y
L
I
L
FSA
S
D
A
L
F
W
F
F
PI
I
L
GY
T
A
GKR
FGG
N
PFT
A
MV
I
G
GA
LV
---
HP
LILTAFEN
G
QKVDALG
L
DF
LGI
P
V
TLLN
Y
SSS
VIP
I
I
FSA
W
L
C
SI
L
E
RR
L
NAWL
P
SAIKNFFT
PL
LC
L
MV
ITP
I
T
F
LL
V
GP
L
S
T
WI
SEL
I
A
AGYLW
L
YQAV
-
PAFAG
AV
M
G
G
F
W
QIF
VM
F
G
L
H
WGLI
P
LI
I
NNF
--
TVL
G
YDT
M
I
PLL
MP
A
IM
AQ
fig|685038.3.peg.3786
Escherichia coli O83:H1 str. NRG 857C (12-336/624)
VGG
A
D
NI
V
S
LM
HC
A
TRLRF
K
L
K
D
ESKAQAEV
L
K
KTP
G
I
I
M
V
VE
S
GG
Q
F
QVVIG
NH
V
AD
-
VFL
A
VNSVA
G
LGE-
-
-
KAQQAPENDDKDNLLN---
--
RF
V
YVISG
IF
T
PLI
G
LM
A
AT
G
I
L
K
G
MLA
L
A
--------
L
T
FQWATEQ-
S
G
T
----
Y
L
I
L
FSA
S
D
A
L
F
W
F
F
PI
I
L
GY
T
A
GKR
FGG
N
PFT
A
MV
I
G
GA
LV
---
HP
LILTAFEN
G
QKVDALG
L
DF
LGI
P
V
TLLN
Y
SSS
VIP
I
I
FSA
W
L
C
SI
L
E
RR
L
NAWL
P
SAIKNFFT
PL
LC
L
MV
ITP
I
T
F
LL
V
GP
L
S
T
WI
SEL
I
A
AGYLW
L
YQAV
-
PAFAG
AV
M
G
G
F
W
QIF
VM
F
G
L
H
WGLI
P
LI
I
NNF
--
TVL
G
YDT
M
I
PLL
MP
A
IM
AQ
fig|409438.11.peg.4180
Escherichia coli SE11 (7-336/625)
K
I
V
AG
VGG
A
D
NI
V
S
LM
HC
A
TRLRF
K
L
K
D
ESKAQAEV
L
K
KTP
G
I
I
M
V
VE
S
GG
Q
F
QVVIG
NH
V
AD
-
VFL
A
VNSVA
G
LGE-
-
-
KAQQAPENDEKGNLLN---
--
RF
V
YVISG
IF
T
PLI
G
LM
A
AT
G
I
L
K
G
MLT
L
A
--------
L
T
FQWTTEQ-
S
G
T
----
Y
L
I
L
FSA
S
D
A
L
F
W
F
F
PI
I
L
GY
T
A
GKR
FGG
N
PFT
A
MV
I
G
GA
LV
---
HP
LILTAFEN
G
QKADALG
L
DF
LGI
P
V
TLLN
Y
SSS
VIP
I
I
FSA
W
L
C
SI
L
E
RR
L
NAWL
P
SAIKNFFT
PL
LC
L
MV
ITP
VT
F
LL
V
GP
L
S
T
WI
SEM
I
A
AGYLW
L
YQAV
-
PAFAG
AV
M
G
G
F
W
QIF
VM
F
G
L
H
WGLV
P
LC
I
NNF
--
TVL
G
YDT
M
I
PLL
MP
A
IM
AQ
fig|525281.3.peg.4217
Escherichia coli 83972 (1-346/474)
MAKEISSELLN
T
I
L
TR
VGG
P
GNI
A
S
CG
N
C
M
TRLR
L
G
V
H
D
SSLVDPD-
IK
TLE
GV
K
GV
IL
T
SD
Q
V
QVV
F
G
PG
K
AH
R
AAK
A
MSELL
G
EAPV
Q
D
AAEIAAQNKRQLKARQTSG
VQ
QF
L
AKFAT
IF
T
PLIP
GF
I
AA
GLLLG
IAT
LI
--------
A
T
VMHVTADA
Q
G
T
LPDA
L
N
F
M
KVF
S
K
G
L
F
T
FL
V
I
L
V
GY
N
A
AQA
FGGT
GVN
G
AI
IA
AL
FLLGY
N
P
TATTGYYA
G
FH-----
-
DF
FGL
PI
---D
P
RGN
I
I
G
V
L
IAA
W
A
C
AR
IE
CM
V
RRFM
P
DDLDMLLT
S
L
IT
LLI
TAT
LA
Y
L
I
I
M
P
L
G
G
W
L
FEG
M
S
WLFMH
L
NS--
-
NPLGC
AV
L
A
G
L
F
LIA
V
V
F
GVH
QGFI
P
VY
L
ALM
--
DSQ
G
FNS
L
F
P
I
L
SM
A
GA
G
Q
fig|655817.3.peg.2865
Escherichia coli ABU 83972 (1-346/474)
MAKEISSELLN
T
I
L
TR
VGG
P
GNI
A
S
CG
N
C
M
TRLR
L
G
V
H
D
SSLVDPD-
IK
TLE
GV
K
GV
IL
T
SD
Q
V
QVV
F
G
PG
K
AH
R
AAK
A
MSELL
G
EAPV
Q
D
AAEIAAQNKRQLKARQTSG
VQ
QF
L
AKFAT
IF
T
PLIP
GF
I
AA
GLLLG
IAT
LI
--------
A
T
VMHVTADA
Q
G
T
LPDA
L
N
F
M
KVF
S
K
G
L
F
T
FL
V
I
L
V
GY
N
A
AQA
FGGT
GVN
G
AI
IA
AL
FLLGY
N
P
TATTGYYA
G
FH-----
-
DF
FGL
PI
---D
P
RGN
I
I
G
V
L
IAA
W
A
C
AR
IE
CM
V
RRFM
P
DDLDMLLT
S
L
IT
LLI
TAT
LA
Y
L
I
I
M
P
L
G
G
W
L
FEG
M
S
WLFMH
L
NS--
-
NPLGC
AV
L
A
G
L
F
LIA
V
V
F
GVH
QGFI
P
VY
L
ALM
--
DSQ
G
FNS
L
F
P
I
L
SM
A
GA
G
Q
fig|199310.1.peg.2887
Escherichia coli CFT073 (1-346/474)
MAKEISSELLN
T
I
L
TR
VGG
P
GNI
A
S
CG
N
C
M
TRLR
L
G
V
H
D
SSLVDPD-
IK
TLE
GV
K
GV
IL
T
SD
Q
V
QVV
F
G
PG
K
AH
R
AAK
A
MSELL
G
EAPV
Q
D
AAEIAAQNKRQLKARQTSG
VQ
QF
L
AKFAT
IF
T
PLIP
GF
I
AA
GLLLG
IAT
LI
--------
A
T
VMHVTADA
Q
G
T
LPDA
L
N
F
M
KVF
S
K
G
L
F
T
FL
V
I
L
V
GY
N
A
AQA
FGGT
GVN
G
AI
IA
AL
FLLGY
N
P
TATTGYYA
G
FH-----
-
DF
FGL
PI
---D
P
RGN
I
I
G
V
L
IAA
W
A
C
AR
IE
CM
V
RRFM
P
DDLDMLLT
S
L
IT
LLI
TAT
LA
Y
L
I
I
M
P
L
G
G
W
L
FEG
M
S
WLFMH
L
NS--
-
NPLGC
AV
L
A
G
L
F
LIA
V
V
F
GVH
QGFI
P
VY
L
ALM
--
DSQ
G
FNS
L
F
P
I
L
SM
A
GA
G
Q
fig|199310.4.peg.2793
Escherichia coli CFT073 (1-346/474)
MAKEISSELLN
T
I
L
TR
VGG
P
GNI
A
S
CG
N
C
M
TRLR
L
G
V
H
D
SSLVDPD-
IK
TLE
GV
K
GV
IL
T
SD
Q
V
QVV
F
G
PG
K
AH
R
AAK
A
MSELL
G
EAPV
Q
D
AAEIAAQNKRQLKARQTSG
VQ
QF
L
AKFAT
IF
T
PLIP
GF
I
AA
GLLLG
IAT
LI
--------
A
T
VMHVTADA
Q
G
T
LPDA
L
N
F
M
KVF
S
K
G
L
F
T
FL
V
I
L
V
GY
N
A
AQA
FGGT
GVN
G
AI
IA
AL
FLLGY
N
P
TATTGYYA
G
FH-----
-
DF
FGL
PI
---D
P
RGN
I
I
G
V
L
IAA
W
A
C
AR
IE
CM
V
RRFM
P
DDLDMLLT
S
L
IT
LLI
TAT
LA
Y
L
I
I
M
P
L
G
G
W
L
FEG
M
S
WLFMH
L
NS--
-
NPLGC
AV
L
A
G
L
F
LIA
V
V
F
GVH
QGFI
P
VY
L
ALM
--
DSQ
G
FNS
L
F
P
I
L
SM
A
GA
G
Q
fig|749546.3.peg.424
Escherichia coli MS 185-1 (1-346/474)
MAKEISSELLN
T
I
L
TR
VGG
P
GNI
A
S
CG
N
C
M
TRLR
L
G
V
H
D
SSLVDPD-
IK
TLE
GV
K
GV
IL
T
SD
Q
V
QVV
F
G
PG
K
AH
R
AAK
A
MSELL
G
EAPV
Q
D
AAEIAAQNKRQLKARQTSG
VQ
QF
L
AKFAT
IF
T
PLIP
GF
I
AA
GLLLG
IAT
LI
--------
A
T
VMHVTADA
Q
G
T
LPDA
L
N
F
M
KVF
S
K
G
L
F
T
FL
V
I
L
V
GY
N
A
AQA
FGGT
GVN
G
AI
IA
AL
FLLGY
N
P
TATTGYYA
G
FH-----
-
DF
FGL
PI
---D
P
RGN
I
I
G
V
L
IAA
W
A
C
AR
IE
CM
V
RRFM
P
DDLDMLLT
S
L
IT
LLI
TAT
LA
Y
L
I
I
M
P
L
G
G
W
L
FEG
M
S
WLFMH
L
NS--
-
NPLGC
AV
L
A
G
L
F
LIA
V
V
F
GVH
QGFI
P
VY
L
ALM
--
DSQ
G
FNS
L
F
P
I
L
SM
A
GA
G
Q
fig|749528.3.peg.2324
Escherichia coli MS 45-1 (1-346/474)
MAKEISSELLN
T
I
L
TR
VGG
P
GNI
A
S
CG
N
C
M
TRLR
L
G
V
H
D
SSLVDPD-
IK
TLE
GV
K
GV
IL
T
SD
Q
V
QVV
F
G
PG
K
AH
R
AAK
A
MSELL
G
EAPV
Q
D
AAEIAAQNKRQLKARQTSG
VQ
QF
L
AKFAT
IF
T
PLIP
GF
I
AA
GLLLG
IAT
LI
--------
A
T
VMHVTADA
Q
G
T
LPDA
L
N
F
M
KVF
S
K
G
L
F
T
FL
V
I
L
V
GY
N
A
AQA
FGGT
GVN
G
AI
IA
AL
FLLGY
N
P
TATTGYYA
G
FH-----
-
DF
FGL
PI
---D
P
RGN
I
I
G
V
L
IAA
W
A
C
AR
IE
CM
V
RRFM
P
DDLDMLLT
S
L
IT
LLI
TAT
LA
Y
L
I
I
M
P
L
G
G
W
L
FEG
M
S
WLFMH
L
NS--
-
NPLGC
AV
L
A
G
L
F
LIA
V
V
F
GVH
QGFI
P
VY
L
ALM
--
DSQ
G
FNS
L
F
P
I
L
SM
A
GA
G
Q
fig|753642.3.peg.2670
Escherichia coli NC101 (1-346/474)
MAKEISSELLN
T
I
L
TR
VGG
P
GNI
A
S
CG
N
C
M
TRLR
L
G
V
H
D
SSLVDPD-
IK
TLE
GV
K
GV
IL
T
SD
Q
V
QVV
F
G
PG
K
AH
R
AAK
A
MSELL
G
EAPV
Q
D
AAEIAAQNKRQLKARQTSG
VQ
QF
L
AKFAT
IF
T
PLIP
GF
I
AA
GLLLG
IAT
LI
--------
A
T
VMHVTADA
Q
G
T
LPDA
L
N
F
M
KVF
S
K
G
L
F
T
FL
V
I
L
V
GY
N
A
AQA
FGGT
GVN
G
AI
IA
AL
FLLGY
N
P
TATTGYYA
G
FH-----
-
DF
FGL
PI
---D
P
RGN
I
I
G
V
L
IAA
W
A
C
AR
IE
CM
V
RRFM
P
DDLDMLLT
S
L
IT
LLI
TAT
LA
Y
L
I
I
M
P
L
G
G
W
L
FEG
M
S
WLFMH
L
NS--
-
NPLGC
AV
L
A
G
L
F
LIA
V
V
F
GVH
QGFI
P
VY
L
ALM
--
DSQ
G
FNS
L
F
P
I
L
SM
A
GA
G
Q
fig|585034.4.peg.3815
Escherichia coli IAI1 (7-336/625)
K
I
V
AG
VGG
A
D
NI
V
S
LM
HC
A
TRLRF
K
L
K
D
ESKAQAEV
L
K
NTP
G
I
I
M
V
VE
S
GG
Q
F
QVVIG
NH
M
AD
-
VFL
A
VNSVA
G
LGE-
-
-
KAQQAPENDEKGNLLN---
--
RF
V
YVISG
IF
T
PLI
G
LM
A
AT
G
I
L
K
G
MLA
L
A
--------
L
T
FQWTTEQ-
S
G
T
----
Y
L
I
L
FSA
S
D
A
L
F
W
F
F
PI
I
L
GY
T
A
GKR
FGG
N
PFT
A
MV
I
G
GA
LV
---
HP
LILTAFEN
G
QKADELG
L
DF
LGI
P
V
TLLN
Y
SSS
VIP
I
I
FSA
W
L
C
SI
L
E
RR
L
NAWL
P
SAIKNFFT
PL
LC
L
MV
ITP
VT
F
LL
V
GP
L
S
T
WI
SEL
I
A
AGYLW
L
YQAV
-
PAFAG
AV
M
G
G
F
W
QIF
VM
F
G
L
H
WGLV
P
LC
I
NNF
--
TVL
G
YDT
M
I
PLL
MP
A
IM
AQ
fig|585034.5.peg.3812
Escherichia coli IAI1 (7-336/625)
K
I
V
AG
VGG
A
D
NI
V
S
LM
HC
A
TRLRF
K
L
K
D
ESKAQAEV
L
K
NTP
G
I
I
M
V
VE
S
GG
Q
F
QVVIG
NH
M
AD
-
VFL
A
VNSVA
G
LGE-
-
-
KAQQAPENDEKGNLLN---
--
RF
V
YVISG
IF
T
PLI
G
LM
A
AT
G
I
L
K
G
MLA
L
A
--------
L
T
FQWTTEQ-
S
G
T
----
Y
L
I
L
FSA
S
D
A
L
F
W
F
F
PI
I
L
GY
T
A
GKR
FGG
N
PFT
A
MV
I
G
GA
LV
---
HP
LILTAFEN
G
QKADELG
L
DF
LGI
P
V
TLLN
Y
SSS
VIP
I
I
FSA
W
L
C
SI
L
E
RR
L
NAWL
P
SAIKNFFT
PL
LC
L
MV
ITP
VT
F
LL
V
GP
L
S
T
WI
SEL
I
A
AGYLW
L
YQAV
-
PAFAG
AV
M
G
G
F
W
QIF
VM
F
G
L
H
WGLV
P
LC
I
NNF
--
TVL
G
YDT
M
I
PLL
MP
A
IM
AQ
fig|358709.5.peg.36
Escherichia coli 101-1 (7-336/625)
K
I
V
AG
VGG
A
D
NI
V
S
LM
HC
A
TRLRF
K
L
K
D
ESKAQAEV
L
K
KTP
G
I
I
M
V
VE
S
GG
Q
F
QVVIG
NH
V
AD
-
VFL
A
VNSVA
G
LGE-
-
-
KAQQAPENDEKGNLLN---
--
RF
V
YVISG
IF
T
PLI
G
LM
A
AT
G
I
L
K
G
MLA
L
A
--------
L
T
FQWTTEQ-
S
G
T
----
Y
L
I
L
FSA
S
D
A
L
F
W
F
F
PI
I
L
GY
T
A
GKR
FGG
N
PFT
A
MV
I
G
GA
LV
---
HP
LILTAFEN
G
QKADALG
L
DF
LGI
P
V
TLLN
Y
SSS
VIP
I
I
FSA
W
L
C
SI
L
E
RR
L
NAWL
P
SAIKNFFT
PL
LC
L
MV
ITP
VT
F
LL
V
GP
L
S
T
WI
SEM
I
A
AGYLW
L
YQAV
-
PAFAG
AV
M
G
G
F
W
QIF
VM
F
G
L
H
WGLV
P
LC
I
NNF
--
TVL
G
YDT
M
I
PLL
MP
A
IM
AQ
fig|413997.3.peg.3784
Escherichia coli B str. REL606 (7-336/625)
K
I
V
AG
VGG
A
D
NI
V
S
LM
HC
A
TRLRF
K
L
K
D
ESKAQAEV
L
K
KTP
G
I
I
M
V
VE
S
GG
Q
F
QVVIG
NH
V
AD
-
VFL
A
VNSVA
G
LGE-
-
-
KAQQAPENDEKGNLLN---
--
RF
V
YVISG
IF
T
PLI
G
LM
A
AT
G
I
L
K
G
MLA
L
A
--------
L
T
FQWTTEQ-
S
G
T
----
Y
L
I
L
FSA
S
D
A
L
F
W
F
F
PI
I
L
GY
T
A
GKR
FGG
N
PFT
A
MV
I
G
GA
LV
---
HP
LILTAFEN
G
QKADALG
L
DF
LGI
P
V
TLLN
Y
SSS
VIP
I
I
FSA
W
L
C
SI
L
E
RR
L
NAWL
P
SAIKNFFT
PL
LC
L
MV
ITP
VT
F
LL
V
GP
L
S
T
WI
SEM
I
A
AGYLW
L
YQAV
-
PAFAG
AV
M
G
G
F
W
QIF
VM
F
G
L
H
WGLV
P
LC
I
NNF
--
TVL
G
YDT
M
I
PLL
MP
A
IM
AQ
fig|511693.5.peg.3802
Escherichia coli BL21 (7-336/625)
K
I
V
AG
VGG
A
D
NI
V
S
LM
HC
A
TRLRF
K
L
K
D
ESKAQAEV
L
K
KTP
G
I
I
M
V
VE
S
GG
Q
F
QVVIG
NH
V
AD
-
VFL
A
VNSVA
G
LGE-
-
-
KAQQAPENDEKGNLLN---
--
RF
V
YVISG
IF
T
PLI
G
LM
A
AT
G
I
L
K
G
MLA
L
A
--------
L
T
FQWTTEQ-
S
G
T
----
Y
L
I
L
FSA
S
D
A
L
F
W
F
F
PI
I
L
GY
T
A
GKR
FGG
N
PFT
A
MV
I
G
GA
LV
---
HP
LILTAFEN
G
QKADALG
L
DF
LGI
P
V
TLLN
Y
SSS
VIP
I
I
FSA
W
L
C
SI
L
E
RR
L
NAWL
P
SAIKNFFT
PL
LC
L
MV
ITP
VT
F
LL
V
GP
L
S
T
WI
SEM
I
A
AGYLW
L
YQAV
-
PAFAG
AV
M
G
G
F
W
QIF
VM
F
G
L
H
WGLV
P
LC
I
NNF
--
TVL
G
YDT
M
I
PLL
MP
A
IM
AQ
fig|469008.4.peg.4485
Escherichia coli BL21(DE3) (7-336/625)
K
I
V
AG
VGG
A
D
NI
V
S
LM
HC
A
TRLRF
K
L
K
D
ESKAQAEV
L
K
KTP
G
I
I
M
V
VE
S
GG
Q
F
QVVIG
NH
V
AD
-
VFL
A
VNSVA
G
LGE-
-
-
KAQQAPENDEKGNLLN---
--
RF
V
YVISG
IF
T
PLI
G
LM
A
AT
G
I
L
K
G
MLA
L
A
--------
L
T
FQWTTEQ-
S
G
T
----
Y
L
I
L
FSA
S
D
A
L
F
W
F
F
PI
I
L
GY
T
A
GKR
FGG
N
PFT
A
MV
I
G
GA
LV
---
HP
LILTAFEN
G
QKADALG
L
DF
LGI
P
V
TLLN
Y
SSS
VIP
I
I
FSA
W
L
C
SI
L
E
RR
L
NAWL
P
SAIKNFFT
PL
LC
L
MV
ITP
VT
F
LL
V
GP
L
S
T
WI
SEM
I
A
AGYLW
L
YQAV
-
PAFAG
AV
M
G
G
F
W
QIF
VM
F
G
L
H
WGLV
P
LC
I
NNF
--
TVL
G
YDT
M
I
PLL
MP
A
IM
AQ
fig|316401.4.peg.4554
Escherichia coli ETEC H10407 (7-336/625)
K
I
V
AG
VGG
A
D
NI
V
S
LM
HC
A
TRLRF
K
L
K
D
ESKAQAEV
L
K
KTP
G
I
I
M
V
VE
S
GG
Q
F
QVVIG
NH
V
AD
-
VFL
A
VNSVA
G
LGE-
-
-
KAQQAPENDEKGNLLN---
--
RF
V
YVISG
IF
T
PLI
G
LM
A
AT
G
I
L
K
G
MLA
L
A
--------
L
T
FQWTTEQ-
S
G
T
----
Y
L
I
L
FSA
S
D
A
L
F
W
F
F
PI
I
L
GY
T
A
GKR
FGG
N
PFT
A
MV
I
G
GA
LV
---
HP
LILTAFEN
G
QKADALG
L
DF
LGI
P
V
TLLN
Y
SSS
VIP
I
I
FSA
W
L
C
SI
L
E
RR
L
NAWL
P
SAIKNFFT
PL
LC
L
MV
ITP
VT
F
LL
V
GP
L
S
T
WI
SEM
I
A
AGYLW
L
YQAV
-
PAFAG
AV
M
G
G
F
W
QIF
VM
F
G
L
H
WGLV
P
LC
I
NNF
--
TVL
G
YDT
M
I
PLL
MP
A
IM
AQ
fig|749547.3.peg.4370
Escherichia coli MS 187-1 (7-336/625)
K
I
V
AG
VGG
A
D
NI
V
S
LM
HC
A
TRLRF
K
L
K
D
ESKAQAEV
L
K
KTP
G
I
I
M
V
VE
S
GG
Q
F
QVVIG
NH
V
AD
-
VFL
A
VNSVA
G
LGE-
-
-
KAQQAPENDEKGNLLN---
--
RF
V
YVISG
IF
T
PLI
G
LM
A
AT
G
I
L
K
G
MLA
L
A
--------
L
T
FQWTTEQ-
S
G
T
----
Y
L
I
L
FSA
S
D
A
L
F
W
F
F
PI
I
L
GY
T
A
GKR
FGG
N
PFT
A
MV
I
G
GA
LV
---
HP
LILTAFEN
G
QKADALG
L
DF
LGI
P
V
TLLN
Y
SSS
VIP
I
I
FSA
W
L
C
SI
L
E
RR
L
NAWL
P
SAIKNFFT
PL
LC
L
MV
ITP
VT
F
LL
V
GP
L
S
T
WI
SEM
I
A
AGYLW
L
YQAV
-
PAFAG
AV
M
G
G
F
W
QIF
VM
F
G
L
H
WGLV
P
LC
I
NNF
--
TVL
G
YDT
M
I
PLL
MP
A
IM
AQ
fig|637912.3.peg.3504
Escherichia coli OP50 (1-346/367)
MAKEISSELLN
T
I
L
TR
VGG
P
GNI
A
S
CG
N
C
M
TRLR
L
G
V
H
D
SSLVDPD-
IK
TLE
GV
K
GV
IL
T
SD
Q
V
QVV
F
G
PG
K
AH
R
AAK
A
MSELL
G
EAPV
Q
D
AAEIAAQNKRQLKAKQTSG
VQ
QF
L
AKFAT
IF
T
PLIP
GF
I
AA
GLLLG
IAT
LI
--------
A
T
VMHVPADA
Q
G
T
LPDA
L
N
F
M
KVF
S
K
G
L
F
T
FL
V
I
L
V
GY
N
A
AQA
FGGT
GVN
G
AI
IA
AL
FLLGY
N
P
AATTGYYA
G
FH-----
-
DF
FGL
PI
---D
P
RGN
I
I
G
V
L
IAA
W
A
C
AR
IE
GM
V
RRFM
P
DDLDMLLT
S
L
IT
LLI
TAT
LA
Y
L
I
I
M
P
L
G
G
W
L
FEG
M
S
WLFMH
L
NS--
-
NPFGC
AV
L
A
G
L
F
LIA
V
V
F
GVH
QGFI
P
VY
L
ALM
--
DSQ
G
FNS
L
F
P
I
L
SM
A
GA
G
Q
fig|405955.13.peg.2681
Escherichia coli APEC O1 (1-346/474)
MAKEISSELLN
T
I
L
TR
VGG
P
GNI
A
S
CG
N
C
M
TRLR
L
G
V
H
D
SSLVDPD-
IK
TLE
GV
K
GV
IL
T
SD
Q
V
QVV
F
G
PG
K
AH
R
AAK
A
MSELL
G
EAPV
Q
D
AAEIAAQNKRQLKARQTSG
VQ
QF
L
AKFAT
IF
T
PLIP
GF
I
AA
GLLLG
IAT
LI
--------
A
T
VMHVTADA
Q
G
T
LPDA
L
N
F
M
KVF
S
K
G
L
F
T
FL
V
I
L
V
GY
N
A
AQA
FGGT
GVN
G
AI
IA
AL
FLLGY
N
P
TATTGYYA
G
FH-----
-
DF
FGL
PI
---D
P
RGN
I
I
G
V
L
IAA
W
A
C
AR
IE
GM
V
RRFM
P
DDLDMLLT
S
L
IT
LLI
TAT
LA
Y
L
I
I
M
P
L
G
G
W
L
FEG
M
S
WLFMH
L
NS--
-
NPLGC
AV
L
A
G
L
F
LIA
V
V
F
GVH
QGFI
P
VY
L
ALM
--
DSQ
G
FNS
L
F
P
I
L
SM
A
GA
G
Q
fig|405955.9.peg.2203
Escherichia coli APEC O1 (1-346/474)
MAKEISSELLN
T
I
L
TR
VGG
P
GNI
A
S
CG
N
C
M
TRLR
L
G
V
H
D
SSLVDPD-
IK
TLE
GV
K
GV
IL
T
SD
Q
V
QVV
F
G
PG
K
AH
R
AAK
A
MSELL
G
EAPV
Q
D
AAEIAAQNKRQLKARQTSG
VQ
QF
L
AKFAT
IF
T
PLIP
GF
I
AA
GLLLG
IAT
LI
--------
A
T
VMHVTADA
Q
G
T
LPDA
L
N
F
M
KVF
S
K
G
L
F
T
FL
V
I
L
V
GY
N
A
AQA
FGGT
GVN
G
AI
IA
AL
FLLGY
N
P
TATTGYYA
G
FH-----
-
DF
FGL
PI
---D
P
RGN
I
I
G
V
L
IAA
W
A
C
AR
IE
GM
V
RRFM
P
DDLDMLLT
S
L
IT
LLI
TAT
LA
Y
L
I
I
M
P
L
G
G
W
L
FEG
M
S
WLFMH
L
NS--
-
NPLGC
AV
L
A
G
L
F
LIA
V
V
F
GVH
QGFI
P
VY
L
ALM
--
DSQ
G
FNS
L
F
P
I
L
SM
A
GA
G
Q
fig|714962.3.peg.2788
Escherichia coli IHE3034 (1-346/474)
MAKEISSELLN
T
I
L
TR
VGG
P
GNI
A
S
CG
N
C
M
TRLR
L
G
V
H
D
SSLVDPD-
IK
TLE
GV
K
GV
IL
T
SD
Q
V
QVV
F
G
PG
K
AH
R
AAK
A
MSELL
G
EAPV
Q
D
AAEIAAQNKRQLKARQTSG
VQ
QF
L
AKFAT
IF
T
PLIP
GF
I
AA
GLLLG
IAT
LI
--------
A
T
VMHVTADA
Q
G
T
LPDA
L
N
F
M
KVF
S
K
G
L
F
T
FL
V
I
L
V
GY
N
A
AQA
FGGT
GVN
G
AI
IA
AL
FLLGY
N
P
TATTGYYA
G
FH-----
-
DF
FGL
PI
---D
P
RGN
I
I
G
V
L
IAA
W
A
C
AR
IE
GM
V
RRFM
P
DDLDMLLT
S
L
IT
LLI
TAT
LA
Y
L
I
I
M
P
L
G
G
W
L
FEG
M
S
WLFMH
L
NS--
-
NPLGC
AV
L
A
G
L
F
LIA
V
V
F
GVH
QGFI
P
VY
L
ALM
--
DSQ
G
FNS
L
F
P
I
L
SM
A
GA
G
Q
fig|585035.6.peg.2586
Escherichia coli S88 (1-346/474)
MAKEISSELLN
T
I
L
TR
VGG
P
GNI
A
S
CG
N
C
M
TRLR
L
G
V
H
D
SSLVDPD-
IK
TLE
GV
K
GV
IL
T
SD
Q
V
QVV
F
G
PG
K
AH
R
AAK
A
MSELL
G
EAPV
Q
D
AAEIAAQNKRQLKARQTSG
VQ
QF
L
AKFAT
IF
T
PLIP
GF
I
AA
GLLLG
IAT
LI
--------
A
T
VMHVTADA
Q
G
T
LPDA
L
N
F
M
KVF
S
K
G
L
F
T
FL
V
I
L
V
GY
N
A
AQA
FGGT
GVN
G
AI
IA
AL
FLLGY
N
P
TATTGYYA
G
FH-----
-
DF
FGL
PI
---D
P
RGN
I
I
G
V
L
IAA
W
A
C
AR
IE
GM
V
RRFM
P
DDLDMLLT
S
L
IT
LLI
TAT
LA
Y
L
I
I
M
P
L
G
G
W
L
FEG
M
S
WLFMH
L
NS--
-
NPLGC
AV
L
A
G
L
F
LIA
V
V
F
GVH
QGFI
P
VY
L
ALM
--
DSQ
G
FNS
L
F
P
I
L
SM
A
GA
G
Q
fig|656440.3.peg.2485
Escherichia coli TA206 (1-346/474)
MAKEISSELLN
T
I
L
TR
VGG
P
GNI
A
S
CG
N
C
M
TRLR
L
G
V
H
D
SSLVDPD-
IK
TLE
GV
K
GV
IL
T
SD
Q
V
QVV
F
G
PG
K
AH
R
AAK
A
MSELL
G
EAPV
Q
D
AAEIAAQNKRQLKARQTSG
VQ
QF
L
AKFAT
IF
T
PLIP
GF
I
AA
GLLLG
IAT
LI
--------
A
T
VMHVTADA
Q
G
T
LPDA
L
N
F
M
KVF
S
K
G
L
F
T
FL
V
I
L
V
GY
N
A
AQA
FGGT
GVN
G
AI
IA
AL
FLLGY
N
P
TATTGYYA
G
FH-----
-
DF
FGL
PI
---D
P
RGN
I
I
G
V
L
IAA
W
A
C
AR
IE
GM
V
RRFM
P
DDLDMLLT
S
L
IT
LLI
TAT
LA
Y
L
I
I
M
P
L
G
G
W
L
FEG
M
S
WLFMH
L
NS--
-
NPLGC
AV
L
A
G
L
F
LIA
V
V
F
GVH
QGFI
P
VY
L
ALM
--
DSQ
G
FNS
L
F
P
I
L
SM
A
GA
G
Q
fig|869729.3.peg.963
Escherichia coli UM146 (1-346/474)
MAKEISSELLN
T
I
L
TR
VGG
P
GNI
A
S
CG
N
C
M
TRLR
L
G
V
H
D
SSLVDPD-
IK
TLE
GV
K
GV
IL
T
SD
Q
V
QVV
F
G
PG
K
AH
R
AAK
A
MSELL
G
EAPV
Q
D
AAEIAAQNKRQLKARQTSG
VQ
QF
L
AKFAT
IF
T
PLIP
GF
I
AA
GLLLG
IAT
LI
--------
A
T
VMHVTADA
Q
G
T
LPDA
L
N
F
M
KVF
S
K
G
L
F
T
FL
V
I
L
V
GY
N
A
AQA
FGGT
GVN
G
AI
IA
AL
FLLGY
N
P
TATTGYYA
G
FH-----
-
DF
FGL
PI
---D
P
RGN
I
I
G
V
L
IAA
W
A
C
AR
IE
GM
V
RRFM
P
DDLDMLLT
S
L
IT
LLI
TAT
LA
Y
L
I
I
M
P
L
G
G
W
L
FEG
M
S
WLFMH
L
NS--
-
NPLGC
AV
L
A
G
L
F
LIA
V
V
F
GVH
QGFI
P
VY
L
ALM
--
DSQ
G
FNS
L
F
P
I
L
SM
A
GA
G
Q
fig|364106.7.peg.2767
Escherichia coli UTI89 (1-346/474)
MAKEISSELLN
T
I
L
TR
VGG
P
GNI
A
S
CG
N
C
M
TRLR
L
G
V
H
D
SSLVDPD-
IK
TLE
GV
K
GV
IL
T
SD
Q
V
QVV
F
G
PG
K
AH
R
AAK
A
MSELL
G
EAPV
Q
D
AAEIAAQNKRQLKARQTSG
VQ
QF
L
AKFAT
IF
T
PLIP
GF
I
AA
GLLLG
IAT
LI
--------
A
T
VMHVTADA
Q
G
T
LPDA
L
N
F
M
KVF
S
K
G
L
F
T
FL
V
I
L
V
GY
N
A
AQA
FGGT
GVN
G
AI
IA
AL
FLLGY
N
P
TATTGYYA
G
FH-----
-
DF
FGL
PI
---D
P
RGN
I
I
G
V
L
IAA
W
A
C
AR
IE
GM
V
RRFM
P
DDLDMLLT
S
L
IT
LLI
TAT
LA
Y
L
I
I
M
P
L
G
G
W
L
FEG
M
S
WLFMH
L
NS--
-
NPLGC
AV
L
A
G
L
F
LIA
V
V
F
GVH
QGFI
P
VY
L
ALM
--
DSQ
G
FNS
L
F
P
I
L
SM
A
GA
G
Q
fig|364106.8.peg.2767
Escherichia coli UTI89 (1-346/474)
MAKEISSELLN
T
I
L
TR
VGG
P
GNI
A
S
CG
N
C
M
TRLR
L
G
V
H
D
SSLVDPD-
IK
TLE
GV
K
GV
IL
T
SD
Q
V
QVV
F
G
PG
K
AH
R
AAK
A
MSELL
G
EAPV
Q
D
AAEIAAQNKRQLKARQTSG
VQ
QF
L
AKFAT
IF
T
PLIP
GF
I
AA
GLLLG
IAT
LI
--------
A
T
VMHVTADA
Q
G
T
LPDA
L
N
F
M
KVF
S
K
G
L
F
T
FL
V
I
L
V
GY
N
A
AQA
FGGT
GVN
G
AI
IA
AL
FLLGY
N
P
TATTGYYA
G
FH-----
-
DF
FGL
PI
---D
P
RGN
I
I
G
V
L
IAA
W
A
C
AR
IE
GM
V
RRFM
P
DDLDMLLT
S
L
IT
LLI
TAT
LA
Y
L
I
I
M
P
L
G
G
W
L
FEG
M
S
WLFMH
L
NS--
-
NPLGC
AV
L
A
G
L
F
LIA
V
V
F
GVH
QGFI
P
VY
L
ALM
--
DSQ
G
FNS
L
F
P
I
L
SM
A
GA
G
Q
fig|595495.4.peg.4891
Escherichia coli KO11 (12-325/485)
V
I
AA
L
GG
V
D
NI
S
A
VT
HC
M
TRLRF
V
I
K
D
DQLIDSPT
L
K
TIP
GV
L
GV
VR
S
DN
Q
Y
QV
I
IG
NT
V
SQ
-
---
A
FQEVV
S
LLPG
-
D
MQPAQPVGKPKLTLRRIGA
--
GI
L
DALIS
TM
S
PLIP
AI
I
GG
S
MV
K
-
LLA
M
I
--------
L
E
MSGVLTKG
S
P
T
----
L
T
I
L
NVI
GDG
A
F
F
FLP
L
M
V
AA
SA
AIK
F
KTN
MSL
A
IA
IA
GV
LV
---
HP
SFIELMAK
A
AQGEHV-
-
E
F
ALI
P
V
TAVK
Y
TYT
VIP
A
L
VMT
W
C
L
SY
IE
RW
V
DRIT
P
AVTKNFLK
P
M
LI
V
LI
AAP
LA
I
LLIGP
I
G
I
WI
GSA
IS
ALVYT
I
HGYL
-
GWLSV
A
I
M
G
A
LW
PLL
VMTG
M
H
RVFT
P
TI
I
QTI
--
AET
G
fig|566546.3.peg.4237
Escherichia coli W (12-325/485)
V
I
AA
L
GG
V
D
NI
S
A
VT
HC
M
TRLRF
V
I
K
D
DQLIDSPT
L
K
TIP
GV
L
GV
VR
S
DN
Q
Y
QV
I
IG
NT
V
SQ
-
---
A
FQEVV
S
LLPG
-
D
MQPAQPVGKPKLTLRRIGA
--
GI
L
DALIS
TM
S
PLIP
AI
I
GG
S
MV
K
-
LLA
M
I
--------
L
E
MSGVLTKG
S
P
T
----
L
T
I
L
NVI
GDG
A
F
F
FLP
L
M
V
AA
SA
AIK
F
KTN
MSL
A
IA
IA
GV
LV
---
HP
SFIELMAK
A
AQGEHV-
-
E
F
ALI
P
V
TAVK
Y
TYT
VIP
A
L
VMT
W
C
L
SY
IE
RW
V
DRIT
P
AVTKNFLK
P
M
LI
V
LI
AAP
LA
I
LLIGP
I
G
I
WI
GSA
IS
ALVYT
I
HGYL
-
GWLSV
A
I
M
G
A
LW
PLL
VMTG
M
H
RVFT
P
TI
I
QTI
--
AET
G
fig|566546.4.peg.2879
Escherichia coli W (12-325/485)
V
I
AA
L
GG
V
D
NI
S
A
VT
HC
M
TRLRF
V
I
K
D
DQLIDSPT
L
K
TIP
GV
L
GV
VR
S
DN
Q
Y
QV
I
IG
NT
V
SQ
-
---
A
FQEVV
S
LLPG
-
D
MQPAQPVGKPKLTLRRIGA
--
GI
L
DALIS
TM
S
PLIP
AI
I
GG
S
MV
K
-
LLA
M
I
--------
L
E
MSGVLTKG
S
P
T
----
L
T
I
L
NVI
GDG
A
F
F
FLP
L
M
V
AA
SA
AIK
F
KTN
MSL
A
IA
IA
GV
LV
---
HP
SFIELMAK
A
AQGEHV-
-
E
F
ALI
P
V
TAVK
Y
TYT
VIP
A
L
VMT
W
C
L
SY
IE
RW
V
DRIT
P
AVTKNFLK
P
M
LI
V
LI
AAP
LA
I
LLIGP
I
G
I
WI
GSA
IS
ALVYT
I
HGYL
-
GWLSV
A
I
M
G
A
LW
PLL
VMTG
M
H
RVFT
P
TI
I
QTI
--
AET
G
fig|362663.8.peg.2476
Escherichia coli 536 (1-346/474)
MAKEISSELLN
T
I
L
TR
VGG
P
GNI
A
S
CG
N
C
M
TRLR
L
G
V
H
D
SSLVDPD-
IK
TLE
GV
K
GV
IL
T
SD
Q
V
QVV
F
G
PG
K
AH
R
AAK
A
MSELL
G
EAPV
Q
D
AAEIAAQNKRQLKARQTSG
VQ
QF
L
AKFAT
IF
T
PLIP
GF
I
AA
GLLLG
IAT
LI
--------
A
T
VMHVPADA
Q
G
T
LPDA
L
N
F
M
KVF
S
K
G
L
F
T
FL
V
I
L
V
GY
N
A
AQA
FGGT
GVN
G
AI
IA
AL
FLLGY
N
P
AATTGYYA
G
FH-----
-
DF
FGL
PI
---D
P
RGN
I
I
G
V
L
IAA
W
A
C
AR
IE
CM
V
RRFM
P
DDLDMLLT
S
L
IT
LLI
TAT
LA
Y
L
I
I
M
P
L
G
G
W
L
FEG
M
S
WLFMH
L
NS--
-
NPLGC
AV
L
A
G
L
F
LIA
V
V
F
GVH
QGFI
P
VY
L
ALM
--
DSQ
G
FNS
L
F
P
I
L
SM
A
GA
G
Q
fig|362663.9.peg.2481
Escherichia coli 536 (1-346/474)
MAKEISSELLN
T
I
L
TR
VGG
P
GNI
A
S
CG
N
C
M
TRLR
L
G
V
H
D
SSLVDPD-
IK
TLE
GV
K
GV
IL
T
SD
Q
V
QVV
F
G
PG
K
AH
R
AAK
A
MSELL
G
EAPV
Q
D
AAEIAAQNKRQLKARQTSG
VQ
QF
L
AKFAT
IF
T
PLIP
GF
I
AA
GLLLG
IAT
LI
--------
A
T
VMHVPADA
Q
G
T
LPDA
L
N
F
M
KVF
S
K
G
L
F
T
FL
V
I
L
V
GY
N
A
AQA
FGGT
GVN
G
AI
IA
AL
FLLGY
N
P
AATTGYYA
G
FH-----
-
DF
FGL
PI
---D
P
RGN
I
I
G
V
L
IAA
W
A
C
AR
IE
CM
V
RRFM
P
DDLDMLLT
S
L
IT
LLI
TAT
LA
Y
L
I
I
M
P
L
G
G
W
L
FEG
M
S
WLFMH
L
NS--
-
NPLGC
AV
L
A
G
L
F
LIA
V
V
F
GVH
QGFI
P
VY
L
ALM
--
DSQ
G
FNS
L
F
P
I
L
SM
A
GA
G
Q
fig|340197.3.peg.3016
Escherichia coli F11 (1-346/474)
MAKEISSELLN
T
I
L
TR
VGG
P
GNI
A
S
CG
N
C
M
TRLR
L
G
V
H
D
SSLVDPD-
IK
TLE
GV
K
GV
IL
T
SD
Q
V
QVV
F
G
PG
K
AH
R
AAK
A
MSELL
G
EAPV
Q
D
AAEIAAQNKRQLKARQTSG
VQ
QF
L
AKFAT
IF
T
PLIP
GF
I
AA
GLLLG
IAT
LI
--------
A
T
VMHVPADA
Q
G
T
LPDA
L
N
F
M
KVF
S
K
G
L
F
T
FL
V
I
L
V
GY
N
A
AQA
FGGT
GVN
G
AI
IA
AL
FLLGY
N
P
AATTGYYA
G
FH-----
-
DF
FGL
PI
---D
P
RGN
I
I
G
V
L
IAA
W
A
C
AR
IE
CM
V
RRFM
P
DDLDMLLT
S
L
IT
LLI
TAT
LA
Y
L
I
I
M
P
L
G
G
W
L
FEG
M
S
WLFMH
L
NS--
-
NPLGC
AV
L
A
G
L
F
LIA
V
V
F
GVH
QGFI
P
VY
L
ALM
--
DSQ
G
FNS
L
F
P
I
L
SM
A
GA
G
Q
fig|340197.5.peg.3152
Escherichia coli F11 (1-346/474)
MAKEISSELLN
T
I
L
TR
VGG
P
GNI
A
S
CG
N
C
M
TRLR
L
G
V
H
D
SSLVDPD-
IK
TLE
GV
K
GV
IL
T
SD
Q
V
QVV
F
G
PG
K
AH
R
AAK
A
MSELL
G
EAPV
Q
D
AAEIAAQNKRQLKARQTSG
VQ
QF
L
AKFAT
IF
T
PLIP
GF
I
AA
GLLLG
IAT
LI
--------
A
T
VMHVPADA
Q
G
T
LPDA
L
N
F
M
KVF
S
K
G
L
F
T
FL
V
I
L
V
GY
N
A
AQA
FGGT
GVN
G
AI
IA
AL
FLLGY
N
P
AATTGYYA
G
FH-----
-
DF
FGL
PI
---D
P
RGN
I
I
G
V
L
IAA
W
A
C
AR
IE
CM
V
RRFM
P
DDLDMLLT
S
L
IT
LLI
TAT
LA
Y
L
I
I
M
P
L
G
G
W
L
FEG
M
S
WLFMH
L
NS--
-
NPLGC
AV
L
A
G
L
F
LIA
V
V
F
GVH
QGFI
P
VY
L
ALM
--
DSQ
G
FNS
L
F
P
I
L
SM
A
GA
G
Q
fig|656417.3.peg.3111
Escherichia coli M605 (1-346/474)
MAKEISSELLN
T
I
L
TR
VGG
P
GNI
A
S
CG
N
C
M
TRLR
L
G
V
H
D
SSLVDPD-
IK
TLE
GV
K
GV
IL
T
SD
Q
V
QVV
F
G
PG
K
AH
R
AAK
A
MSELL
G
EAPV
Q
D
AAEIAAQNKRQLKARQTSG
VQ
QF
L
AKFAT
IF
T
PLIP
GF
I
AA
GLLLG
IAT
LI
--------
A
T
VMHVPADA
Q
G
T
LPDA
L
N
F
M
KVF
S
K
G
L
F
T
FL
V
I
L
V
GY
N
A
AQA
FGGT
GVN
G
AI
IA
AL
FLLGY
N
P
AATTGYYA
G
FH-----
-
DF
FGL
PI
---D
P
RGN
I
I
G
V
L
IAA
W
A
C
AR
IE
CM
V
RRFM
P
DDLDMLLT
S
L
IT
LLI
TAT
LA
Y
L
I
I
M
P
L
G
G
W
L
FEG
M
S
WLFMH
L
NS--
-
NPLGC
AV
L
A
G
L
F
LIA
V
V
F
GVH
QGFI
P
VY
L
ALM
--
DSQ
G
FNS
L
F
P
I
L
SM
A
GA
G
Q
fig|749550.3.peg.5103
Escherichia coli MS 200-1 (1-346/474)
MAKEISSELLN
T
I
L
TR
VGG
P
GNI
A
S
CG
N
C
M
TRLR
L
G
V
H
D
SSLVDPD-
IK
TLE
GV
K
GV
IL
T
SD
Q
V
QVV
F
G
PG
K
AH
R
AAK
A
MSELL
G
EAPV
Q
D
AAEIAAQNKRQLKARQTSG
VQ
QF
L
AKFAT
IF
T
PLIP
GF
I
AA
GLLLG
IAT
LI
--------
A
T
VMHVPADA
Q
G
T
LPDA
L
N
F
M
KVF
S
K
G
L
F
T
FL
V
I
L
V
GY
N
A
AQA
FGGT
GVN
G
AI
IA
AL
FLLGY
N
P
AATTGYYA
G
FH-----
-
DF
FGL
PI
---D
P
RGN
I
I
G
V
L
IAA
W
A
C
AR
IE
CM
V
RRFM
P
DDLDMLLT
S
L
IT
LLI
TAT
LA
Y
L
I
I
M
P
L
G
G
W
L
FEG
M
S
WLFMH
L
NS--
-
NPLGC
AV
L
A
G
L
F
LIA
V
V
F
GVH
QGFI
P
VY
L
ALM
--
DSQ
G
FNS
L
F
P
I
L
SM
A
GA
G
Q
fig|562.376.peg.4346
Escherichia coli WV_060327 (1-346/474)
MAKEISSELLN
T
I
L
TR
VGG
P
GNI
A
S
CG
N
C
M
TRLR
L
G
V
H
D
SSLVDPD-
IK
TLE
GV
K
GV
IL
T
SD
Q
V
QVV
F
G
PG
K
AH
R
AAK
A
MSELL
G
EAPV
Q
D
AAEIAAQNKRQLKTRQTSG
VQ
QF
L
AKFAT
IF
T
PLIP
GF
I
AA
GLLLG
IAT
LI
--------
A
T
VMHVPADA
Q
G
T
LPDA
L
N
F
M
KVF
S
K
G
L
F
T
FL
V
I
L
V
GY
N
A
AQA
FGGT
GVN
G
AI
IA
AL
FLLGY
N
P
TATTGYYA
G
FH-----
-
DF
FGL
PI
---D
P
RGN
I
I
G
V
L
IAA
W
A
C
AR
IE
CM
V
RRFM
P
DDLDMLLT
S
L
IT
LLI
TAT
LA
Y
L
I
I
M
P
L
G
G
W
L
FEG
M
S
WLFMH
L
NS--
-
NPLGC
AV
L
A
G
L
F
LIA
V
V
F
GVH
QGFI
P
VY
L
ALM
--
DSQ
G
FNS
L
F
P
I
L
SM
A
GA
G
Q
fig|585395.4.peg.3399
Escherichia coli O103:H2 str. 12009 (12-325/384)
V
I
AA
L
GG
V
D
NI
S
A
VT
HC
M
TRLRF
V
I
K
D
DQLIDSPT
L
K
TIP
GV
L
GV
VR
S
DN
Q
C
QV
I
IG
NT
V
SQ
-
---
A
FQEVV
S
LLPG
-
D
MQPAQPVGKPKLTLRRIGA
--
GI
L
DALIS
TM
S
PLIP
AI
I
GG
S
MV
K
-
LLA
M
I
--------
L
E
MSGVLTKG
S
P
T
----
L
T
I
L
NVI
GDG
A
F
F
FLP
L
M
V
AA
SA
AIK
F
KTN
MSL
A
IA
IA
GV
LV
---
HP
SFIELMAK
A
ALGEHV-
-
E
F
ALI
P
V
TAVK
Y
TYT
VIP
A
L
VMT
W
C
L
SY
IE
RW
V
DRIT
P
AVTKNFLK
P
M
LI
V
LI
AAP
LA
I
LLIGP
I
G
I
WI
GSA
IS
ALVYT
I
HGYL
-
GWLSV
A
I
M
G
A
LW
PLL
VMTG
M
H
RVFT
P
TI
I
QTI
--
AET
G
fig|444450.8.peg.3627
Escherichia coli O157:H7 str. EC4115 (1-346/474)
MAKEISSELLN
T
I
L
TR
VGG
P
GNI
A
S
CG
N
C
M
TRLR
L
G
V
H
D
SSLVDPD-
IK
TLE
GV
K
GV
IL
T
SD
Q
V
QVV
F
G
PG
K
AH
R
AAK
A
MSELL
G
EAPV
Q
D
AAEIAAQNKRQLKAKQTSG
VQ
QF
L
AKFAT
IF
T
PLIP
GF
I
AA
GLLLG
IAT
LI
--------
A
T
VMHVPADA
Q
D
T
LPDA
L
N
F
M
KVF
S
K
G
L
F
T
FL
V
I
L
V
GY
N
A
AQA
FGGT
GVN
G
AI
IA
AL
FLLGY
N
P
AATTGYYA
G
FH-----
-
DF
FGL
PI
---D
P
RGN
I
I
G
V
L
IAA
W
A
C
AR
IE
GM
V
RRFM
P
DDLDMLLT
S
L
IT
LLI
TAT
LA
Y
L
I
I
M
P
L
G
G
W
L
FEG
M
S
WLFMH
L
NS--
-
NPLGC
AV
L
A
G
L
F
LIA
V
V
F
GVH
QGFI
P
VY
L
ALM
--
DSQ
G
FNS
L
F
P
I
L
SM
A
GA
G
Q
fig|656444.3.peg.3424
Escherichia coli TA280 (1-346/474)
MAKEISSELLN
T
I
L
TR
VGG
P
GNI
A
S
CG
N
C
M
TRLR
L
G
V
H
D
SSLVDPD-
IK
TLE
GV
K
GV
IL
T
SD
Q
V
QVV
F
G
PG
K
AH
R
AAK
A
MSELL
G
EAPV
Q
D
AAEIAAQNKRQLKARQTSG
VQ
QF
L
AKFAT
IF
T
PLIP
GF
I
AA
GLLLG
IAT
LI
--------
A
T
VMHVPADA
Q
G
T
LPDA
L
N
F
M
KVF
S
K
G
L
F
T
FL
V
I
L
V
GY
N
A
AQA
FGGT
GVN
G
AI
IA
AL
FLLGY
N
P
AATTGYYA
G
FH-----
-
DF
FGL
PI
---D
P
RGN
I
I
G
V
L
IAA
W
A
C
AR
IE
GM
V
RRFM
P
DDLDMLLT
S
L
IT
LLI
TAT
LA
Y
L
I
I
M
P
L
G
G
W
L
FEG
M
S
WLFMH
L
NS--
-
NPLGC
AV
L
A
G
L
F
LIA
V
V
F
GVH
QGFI
P
VY
L
ALM
--
DSQ
G
FNS
L
F
P
I
L
SM
A
GA
G
Q
fig|562.371.peg.5297
Escherichia coli 1044A (1-346/474)
MAKEISSELLN
T
I
L
TR
VGG
P
GNI
A
S
CG
N
C
M
TRLR
L
G
V
H
D
SSLVDPD-
IK
TLE
GV
K
GV
IL
T
SD
Q
V
QVV
F
G
PG
K
AH
R
AAK
A
MSELL
G
EAPV
Q
D
AAEIAAQNKRQLKAKQTSG
VQ
QF
L
AKFAT
IF
T
PLIP
GF
I
AA
GLLLG
IAT
LI
--------
A
T
VMHVPADA
Q
G
T
LPDA
L
N
F
M
KVF
S
K
G
L
F
T
FL
V
I
L
V
GY
N
A
AQA
FGGT
GVN
G
AI
IA
AL
FLLGY
N
P
AATTGYYA
G
FH-----
-
DF
FGL
PI
---D
P
RGN
I
I
G
V
L
IAA
W
A
C
AR
IE
GM
V
RRFM
P
DDLDMLLT
S
L
IT
LLI
TAT
LA
Y
L
I
I
M
P
L
G
G
W
L
FEG
M
S
WLFMH
L
NS--
-
NPLGC
AV
L
A
G
L
F
LIA
V
V
F
GVH
QGFI
P
VY
L
ALM
--
DSQ
G
FNS
L
F
P
I
L
SM
A
GA
G
Q
fig|562.373.peg.3623
Escherichia coli 1125A (1-346/474)
MAKEISSELLN
T
I
L
TR
VGG
P
GNI
A
S
CG
N
C
M
TRLR
L
G
V
H
D
SSLVDPD-
IK
TLE
GV
K
GV
IL
T
SD
Q
V
QVV
F
G
PG
K
AH
R
AAK
A
MSELL
G
EAPV
Q
D
AAEIAAQNKRQLKAKQTSG
VQ
QF
L
AKFAT
IF
T
PLIP
GF
I
AA
GLLLG
IAT
LI
--------
A
T
VMHVPADA
Q
G
T
LPDA
L
N
F
M
KVF
S
K
G
L
F
T
FL
V
I
L
V
GY
N
A
AQA
FGGT
GVN
G
AI
IA
AL
FLLGY
N
P
AATTGYYA
G
FH-----
-
DF
FGL
PI
---D
P
RGN
I
I
G
V
L
IAA
W
A
C
AR
IE
GM
V
RRFM
P
DDLDMLLT
S
L
IT
LLI
TAT
LA
Y
L
I
I
M
P
L
G
G
W
L
FEG
M
S
WLFMH
L
NS--
-
NPLGC
AV
L
A
G
L
F
LIA
V
V
F
GVH
QGFI
P
VY
L
ALM
--
DSQ
G
FNS
L
F
P
I
L
SM
A
GA
G
Q
fig|562.372.peg.1846
Escherichia coli 1212A (1-346/474)
MAKEISSELLN
T
I
L
TR
VGG
P
GNI
A
S
CG
N
C
M
TRLR
L
G
V
H
D
SSLVDPD-
IK
TLE
GV
K
GV
IL
T
SD
Q
V
QVV
F
G
PG
K
AH
R
AAK
A
MSELL
G
EAPV
Q
D
AAEIAAQNKRQLKAKQTSG
VQ
QF
L
AKFAT
IF
T
PLIP
GF
I
AA
GLLLG
IAT
LI
--------
A
T
VMHVPADA
Q
G
T
LPDA
L
N
F
M
KVF
S
K
G
L
F
T
FL
V
I
L
V
GY
N
A
AQA
FGGT
GVN
G
AI
IA
AL
FLLGY
N
P
AATTGYYA
G
FH-----
-
DF
FGL
PI
---D
P
RGN
I
I
G
V
L
IAA
W
A
C
AR
IE
GM
V
RRFM
P
DDLDMLLT
S
L
IT
LLI
TAT
LA
Y
L
I
I
M
P
L
G
G
W
L
FEG
M
S
WLFMH
L
NS--
-
NPLGC
AV
L
A
G
L
F
LIA
V
V
F
GVH
QGFI
P
VY
L
ALM
--
DSQ
G
FNS
L
F
P
I
L
SM
A
GA
G
Q
fig|562.374.peg.3048
Escherichia coli 536A (1-346/474)
MAKEISSELLN
T
I
L
TR
VGG
P
GNI
A
S
CG
N
C
M
TRLR
L
G
V
H
D
SSLVDPD-
IK
TLE
GV
K
GV
IL
T
SD
Q
V
QVV
F
G
PG
K
AH
R
AAK
A
MSELL
G
EAPV
Q
D
AAEIAAQNKRQLKAKQTSG
VQ
QF
L
AKFAT
IF
T
PLIP
GF
I
AA
GLLLG
IAT
LI
--------
A
T
VMHVPADA
Q
G
T
LPDA
L
N
F
M
KVF
S
K
G
L
F
T
FL
V
I
L
V
GY
N
A
AQA
FGGT
GVN
G
AI
IA
AL
FLLGY
N
P
AATTGYYA
G
FH-----
-
DF
FGL
PI
---D
P
RGN
I
I
G
V
L
IAA
W
A
C
AR
IE
GM
V
RRFM
P
DDLDMLLT
S
L
IT
LLI
TAT
LA
Y
L
I
I
M
P
L
G
G
W
L
FEG
M
S
WLFMH
L
NS--
-
NPLGC
AV
L
A
G
L
F
LIA
V
V
F
GVH
QGFI
P
VY
L
ALM
--
DSQ
G
FNS
L
F
P
I
L
SM
A
GA
G
Q
fig|550676.3.peg.1629
Escherichia coli B185 (1-346/474)
MAKEISSELLN
T
I
L
TR
VGG
P
GNI
A
S
CG
N
C
M
TRLR
L
G
V
H
D
SSLVDPD-
IK
TLE
GV
K
GV
IL
T
SD
Q
V
QVV
F
G
PG
K
AH
R
AAK
A
MSELL
G
EAPV
Q
D
AAEIAAQNKRQLKAKQTSG
VQ
QF
L
AKFAT
IF
T
PLIP
GF
I
AA
GLLLG
IAT
LI
--------
A
T
VMHVPADA
Q
G
T
LPDA
L
N
F
M
KVF
S
K
G
L
F
T
FL
V
I
L
V
GY
N
A
AQA
FGGT
GVN
G
AI
IA
AL
FLLGY
N
P
AATTGYYA
G
FH-----
-
DF
FGL
PI
---D
P
RGN
I
I
G
V
L
IAA
W
A
C
AR
IE
GM
V
RRFM
P
DDLDMLLT
S
L
IT
LLI
TAT
LA
Y
L
I
I
M
P
L
G
G
W
L
FEG
M
S
WLFMH
L
NS--
-
NPLGC
AV
L
A
G
L
F
LIA
V
V
F
GVH
QGFI
P
VY
L
ALM
--
DSQ
G
FNS
L
F
P
I
L
SM
A
GA
G
Q
fig|656419.3.peg.3194
Escherichia coli M718 (1-346/474)
MAKEISSELLN
T
I
L
TR
VGG
P
GNI
A
S
CG
N
C
M
TRLR
L
G
V
H
D
SSLVDPD-
IK
TLE
GV
K
GV
IL
T
SD
Q
V
QVV
F
G
PG
K
AH
R
AAK
A
MSELL
G
EAPV
Q
D
AAEIAAQNKRQLKAKQTSG
VQ
QF
L
AKFAT
IF
T
PLIP
GF
I
AA
GLLLG
IAT
LI
--------
A
T
VMHVPADA
Q
G
T
LPDA
L
N
F
M
KVF
S
K
G
L
F
T
FL
V
I
L
V
GY
N
A
AQA
FGGT
GVN
G
AI
IA
AL
FLLGY
N
P
AATTGYYA
G
FH-----
-
DF
FGL
PI
---D
P
RGN
I
I
G
V
L
IAA
W
A
C
AR
IE
GM
V
RRFM
P
DDLDMLLT
S
L
IT
LLI
TAT
LA
Y
L
I
I
M
P
L
G
G
W
L
FEG
M
S
WLFMH
L
NS--
-
NPLGC
AV
L
A
G
L
F
LIA
V
V
F
GVH
QGFI
P
VY
L
ALM
--
DSQ
G
FNS
L
F
P
I
L
SM
A
GA
G
Q
fig|749531.3.peg.2680
Escherichia coli MS 69-1 (1-346/474)
MAKEISSELLN
T
I
L
TR
VGG
P
GNI
A
S
CG
N
C
M
TRLR
L
G
V
H
D
SSLVDPD-
IK
TLE
GV
K
GV
IL
T
SD
Q
V
QVV
F
G
PG
K
AH
R
AAK
A
MSELL
G
EAPV
Q
D
AAEIAAQNKRQLKAKQTSG
VQ
QF
L
AKFAT
IF
T
PLIP
GF
I
AA
GLLLG
IAT
LI
--------
A
T
VMHVPADA
Q
G
T
LPDA
L
N
F
M
KVF
S
K
G
L
F
T
FL
V
I
L
V
GY
N
A
AQA
FGGT
GVN
G
AI
IA
AL
FLLGY
N
P
AATTGYYA
G
FH-----
-
DF
FGL
PI
---D
P
RGN
I
I
G
V
L
IAA
W
A
C
AR
IE
GM
V
RRFM
P
DDLDMLLT
S
L
IT
LLI
TAT
LA
Y
L
I
I
M
P
L
G
G
W
L
FEG
M
S
WLFMH
L
NS--
-
NPLGC
AV
L
A
G
L
F
LIA
V
V
F
GVH
QGFI
P
VY
L
ALM
--
DSQ
G
FNS
L
F
P
I
L
SM
A
GA
G
Q
fig|83334.1.peg.3297
Escherichia coli O157:H7 (1-346/474)
MAKEISSELLN
T
I
L
TR
VGG
P
GNI
A
S
CG
N
C
M
TRLR
L
G
V
H
D
SSLVDPD-
IK
TLE
GV
K
GV
IL
T
SD
Q
V
QVV
F
G
PG
K
AH
R
AAK
A
MSELL
G
EAPV
Q
D
AAEIAAQNKRQLKAKQTSG
VQ
QF
L
AKFAT
IF
T
PLIP
GF
I
AA
GLLLG
IAT
LI
--------
A
T
VMHVPADA
Q
G
T
LPDA
L
N
F
M
KVF
S
K
G
L
F
T
FL
V
I
L
V
GY
N
A
AQA
FGGT
GVN
G
AI
IA
AL
FLLGY
N
P
AATTGYYA
G
FH-----
-
DF
FGL
PI
---D
P
RGN
I
I
G
V
L
IAA
W
A
C
AR
IE
GM
V
RRFM
P
DDLDMLLT
S
L
IT
LLI
TAT
LA
Y
L
I
I
M
P
L
G
G
W
L
FEG
M
S
WLFMH
L
NS--
-
NPLGC
AV
L
A
G
L
F
LIA
V
V
F
GVH
QGFI
P
VY
L
ALM
--
DSQ
G
FNS
L
F
P
I
L
SM
A
GA
G
Q
fig|155864.1.peg.3298
Escherichia coli O157:H7 EDL933 (1-346/474)
MAKEISSELLN
T
I
L
TR
VGG
P
GNI
A
S
CG
N
C
M
TRLR
L
G
V
H
D
SSLVDPD-
IK
TLE
GV
K
GV
IL
T
SD
Q
V
QVV
F
G
PG
K
AH
R
AAK
A
MSELL
G
EAPV
Q
D
AAEIAAQNKRQLKAKQTSG
VQ
QF
L
AKFAT
IF
T
PLIP
GF
I
AA
GLLLG
IAT
LI
--------
A
T
VMHVPADA
Q
G
T
LPDA
L
N
F
M
KVF
S
K
G
L
F
T
FL
V
I
L
V
GY
N
A
AQA
FGGT
GVN
G
AI
IA
AL
FLLGY
N
P
AATTGYYA
G
FH-----
-
DF
FGL
PI
---D
P
RGN
I
I
G
V
L
IAA
W
A
C
AR
IE
GM
V
RRFM
P
DDLDMLLT
S
L
IT
LLI
TAT
LA
Y
L
I
I
M
P
L
G
G
W
L
FEG
M
S
WLFMH
L
NS--
-
NPLGC
AV
L
A
G
L
F
LIA
V
V
F
GVH
QGFI
P
VY
L
ALM
--
DSQ
G
FNS
L
F
P
I
L
SM
A
GA
G
Q
fig|155864.8.peg.3203
Escherichia coli O157:H7 EDL933 (1-346/474)
MAKEISSELLN
T
I
L
TR
VGG
P
GNI
A
S
CG
N
C
M
TRLR
L
G
V
H
D
SSLVDPD-
IK
TLE
GV
K
GV
IL
T
SD
Q
V
QVV
F
G
PG
K
AH
R
AAK
A
MSELL
G
EAPV
Q
D
AAEIAAQNKRQLKAKQTSG
VQ
QF
L
AKFAT
IF
T
PLIP
GF
I
AA
GLLLG
IAT
LI
--------
A
T
VMHVPADA
Q
G
T
LPDA
L
N
F
M
KVF
S
K
G
L
F
T
FL
V
I
L
V
GY
N
A
AQA
FGGT
GVN
G
AI
IA
AL
FLLGY
N
P
AATTGYYA
G
FH-----
-
DF
FGL
PI
---D
P
RGN
I
I
G
V
L
IAA
W
A
C
AR
IE
GM
V
RRFM
P
DDLDMLLT
S
L
IT
LLI
TAT
LA
Y
L
I
I
M
P
L
G
G
W
L
FEG
M
S
WLFMH
L
NS--
-
NPLGC
AV
L
A
G
L
F
LIA
V
V
F
GVH
QGFI
P
VY
L
ALM
--
DSQ
G
FNS
L
F
P
I
L
SM
A
GA
G
Q
fig|444454.5.peg.2318
Escherichia coli O157:H7 str. EC4024 (1-346/474)
MAKEISSELLN
T
I
L
TR
VGG
P
GNI
A
S
CG
N
C
M
TRLR
L
G
V
H
D
SSLVDPD-
IK
TLE
GV
K
GV
IL
T
SD
Q
V
QVV
F
G
PG
K
AH
R
AAK
A
MSELL
G
EAPV
Q
D
AAEIAAQNKRQLKAKQTSG
VQ
QF
L
AKFAT
IF
T
PLIP
GF
I
AA
GLLLG
IAT
LI
--------
A
T
VMHVPADA
Q
G
T
LPDA
L
N
F
M
KVF
S
K
G
L
F
T
FL
V
I
L
V
GY
N
A
AQA
FGGT
GVN
G
AI
IA
AL
FLLGY
N
P
AATTGYYA
G
FH-----
-
DF
FGL
PI
---D
P
RGN
I
I
G
V
L
IAA
W
A
C
AR
IE
GM
V
RRFM
P
DDLDMLLT
S
L
IT
LLI
TAT
LA
Y
L
I
I
M
P
L
G
G
W
L
FEG
M
S
WLFMH
L
NS--
-
NPLGC
AV
L
A
G
L
F
LIA
V
V
F
GVH
QGFI
P
VY
L
ALM
--
DSQ
G
FNS
L
F
P
I
L
SM
A
GA
G
Q
fig|444449.5.peg.1784
Escherichia coli O157:H7 str. EC4042 (1-346/474)
MAKEISSELLN
T
I
L
TR
VGG
P
GNI
A
S
CG
N
C
M
TRLR
L
G
V
H
D
SSLVDPD-
IK
TLE
GV
K
GV
IL
T
SD
Q
V
QVV
F
G
PG
K
AH
R
AAK
A
MSELL
G
EAPV
Q
D
AAEIAAQNKRQLKAKQTSG
VQ
QF
L
AKFAT
IF
T
PLIP
GF
I
AA
GLLLG
IAT
LI
--------
A
T
VMHVPADA
Q
G
T
LPDA
L
N
F
M
KVF
S
K
G
L
F
T
FL
V
I
L
V
GY
N
A
AQA
FGGT
GVN
G
AI
IA
AL
FLLGY
N
P
AATTGYYA
G
FH-----
-
DF
FGL
PI
---D
P
RGN
I
I
G
V
L
IAA
W
A
C
AR
IE
GM
V
RRFM
P
DDLDMLLT
S
L
IT
LLI
TAT
LA
Y
L
I
I
M
P
L
G
G
W
L
FEG
M
S
WLFMH
L
NS--
-
NPLGC
AV
L
A
G
L
F
LIA
V
V
F
GVH
QGFI
P
VY
L
ALM
--
DSQ
G
FNS
L
F
P
I
L
SM
A
GA
G
Q
fig|444448.5.peg.538
Escherichia coli O157:H7 str. EC4045 (1-346/474)
MAKEISSELLN
T
I
L
TR
VGG
P
GNI
A
S
CG
N
C
M
TRLR
L
G
V
H
D
SSLVDPD-
IK
TLE
GV
K
GV
IL
T
SD
Q
V
QVV
F
G
PG
K
AH
R
AAK
A
MSELL
G
EAPV
Q
D
AAEIAAQNKRQLKAKQTSG
VQ
QF
L
AKFAT
IF
T
PLIP
GF
I
AA
GLLLG
IAT
LI
--------
A
T
VMHVPADA
Q
G
T
LPDA
L
N
F
M
KVF
S
K
G
L
F
T
FL
V
I
L
V
GY
N
A
AQA
FGGT
GVN
G
AI
IA
AL
FLLGY
N
P
AATTGYYA
G
FH-----
-
DF
FGL
PI
---D
P
RGN
I
I
G
V
L
IAA
W
A
C
AR
IE
GM
V
RRFM
P
DDLDMLLT
S
L
IT
LLI
TAT
LA
Y
L
I
I
M
P
L
G
G
W
L
FEG
M
S
WLFMH
L
NS--
-
NPLGC
AV
L
A
G
L
F
LIA
V
V
F
GVH
QGFI
P
VY
L
ALM
--
DSQ
G
FNS
L
F
P
I
L
SM
A
GA
G
Q
fig|444453.5.peg.20
Escherichia coli O157:H7 str. EC4076 (1-346/474)
MAKEISSELLN
T
I
L
TR
VGG
P
GNI
A
S
CG
N
C
M
TRLR
L
G
V
H
D
SSLVDPD-
IK
TLE
GV
K
GV
IL
T
SD
Q
V
QVV
F
G
PG
K
AH
R
AAK
A
MSELL
G
EAPV
Q
D
AAEIAAQNKRQLKAKQTSG
VQ
QF
L
AKFAT
IF
T
PLIP
GF
I
AA
GLLLG
IAT
LI
--------
A
T
VMHVPADA
Q
G
T
LPDA
L
N
F
M
KVF
S
K
G
L
F
T
FL
V
I
L
V
GY
N
A
AQA
FGGT
GVN
G
AI
IA
AL
FLLGY
N
P
AATTGYYA
G
FH-----
-
DF
FGL
PI
---D
P
RGN
I
I
G
V
L
IAA
W
A
C
AR
IE
GM
V
RRFM
P
DDLDMLLT
S
L
IT
LLI
TAT
LA
Y
L
I
I
M
P
L
G
G
W
L
FEG
M
S
WLFMH
L
NS--
-
NPLGC
AV
L
A
G
L
F
LIA
V
V
F
GVH
QGFI
P
VY
L
ALM
--
DSQ
G
FNS
L
F
P
I
L
SM
A
GA
G
Q
fig|444452.5.peg.1572
Escherichia coli O157:H7 str. EC4113 (1-346/474)
MAKEISSELLN
T
I
L
TR
VGG
P
GNI
A
S
CG
N
C
M
TRLR
L
G
V
H
D
SSLVDPD-
IK
TLE
GV
K
GV
IL
T
SD
Q
V
QVV
F
G
PG
K
AH
R
AAK
A
MSELL
G
EAPV
Q
D
AAEIAAQNKRQLKAKQTSG
VQ
QF
L
AKFAT
IF
T
PLIP
GF
I
AA
GLLLG
IAT
LI
--------
A
T
VMHVPADA
Q
G
T
LPDA
L
N
F
M
KVF
S
K
G
L
F
T
FL
V
I
L
V
GY
N
A
AQA
FGGT
GVN
G
AI
IA
AL
FLLGY
N
P
AATTGYYA
G
FH-----
-
DF
FGL
PI
---D
P
RGN
I
I
G
V
L
IAA
W
A
C
AR
IE
GM
V
RRFM
P
DDLDMLLT
S
L
IT
LLI
TAT
LA
Y
L
I
I
M
P
L
G
G
W
L
FEG
M
S
WLFMH
L
NS--
-
NPLGC
AV
L
A
G
L
F
LIA
V
V
F
GVH
QGFI
P
VY
L
ALM
--
DSQ
G
FNS
L
F
P
I
L
SM
A
GA
G
Q
fig|444451.5.peg.1342
Escherichia coli O157:H7 str. EC4196 (1-346/474)
MAKEISSELLN
T
I
L
TR
VGG
P
GNI
A
S
CG
N
C
M
TRLR
L
G
V
H
D
SSLVDPD-
IK
TLE
GV
K
GV
IL
T
SD
Q
V
QVV
F
G
PG
K
AH
R
AAK
A
MSELL
G
EAPV
Q
D
AAEIAAQNKRQLKAKQTSG
VQ
QF
L
AKFAT
IF
T
PLIP
GF
I
AA
GLLLG
IAT
LI
--------
A
T
VMHVPADA
Q
G
T
LPDA
L
N
F
M
KVF
S
K
G
L
F
T
FL
V
I
L
V
GY
N
A
AQA
FGGT
GVN
G
AI
IA
AL
FLLGY
N
P
AATTGYYA
G
FH-----
-
DF
FGL
PI
---D
P
RGN
I
I
G
V
L
IAA
W
A
C
AR
IE
GM
V
RRFM
P
DDLDMLLT
S
L
IT
LLI
TAT
LA
Y
L
I
I
M
P
L
G
G
W
L
FEG
M
S
WLFMH
L
NS--
-
NPLGC
AV
L
A
G
L
F
LIA
V
V
F
GVH
QGFI
P
VY
L
ALM
--
DSQ
G
FNS
L
F
P
I
L
SM
A
GA
G
Q
fig|444447.5.peg.678
Escherichia coli O157:H7 str. EC4206 (1-346/474)
MAKEISSELLN
T
I
L
TR
VGG
P
GNI
A
S
CG
N
C
M
TRLR
L
G
V
H
D
SSLVDPD-
IK
TLE
GV
K
GV
IL
T
SD
Q
V
QVV
F
G
PG
K
AH
R
AAK
A
MSELL
G
EAPV
Q
D
AAEIAAQNKRQLKAKQTSG
VQ
QF
L
AKFAT
IF
T
PLIP
GF
I
AA
GLLLG
IAT
LI
--------
A
T
VMHVPADA
Q
G
T
LPDA
L
N
F
M
KVF
S
K
G
L
F
T
FL
V
I
L
V
GY
N
A
AQA
FGGT
GVN
G
AI
IA
AL
FLLGY
N
P
AATTGYYA
G
FH-----
-
DF
FGL
PI
---D
P
RGN
I
I
G
V
L
IAA
W
A
C
AR
IE
GM
V
RRFM
P
DDLDMLLT
S
L
IT
LLI
TAT
LA
Y
L
I
I
M
P
L
G
G
W
L
FEG
M
S
WLFMH
L
NS--
-
NPLGC
AV
L
A
G
L
F
LIA
V
V
F
GVH
QGFI
P
VY
L
ALM
--
DSQ
G
FNS
L
F
P
I
L
SM
A
GA
G
Q
fig|478004.5.peg.2939
Escherichia coli O157:H7 str. EC4401 (1-346/474)
MAKEISSELLN
T
I
L
TR
VGG
P
GNI
A
S
CG
N
C
M
TRLR
L
G
V
H
D
SSLVDPD-
IK
TLE
GV
K
GV
IL
T
SD
Q
V
QVV
F
G
PG
K
AH
R
AAK
A
MSELL
G
EAPV
Q
D
AAEIAAQNKRQLKAKQTSG
VQ
QF
L
AKFAT
IF
T
PLIP
GF
I
AA
GLLLG
IAT
LI
--------
A
T
VMHVPADA
Q
G
T
LPDA
L
N
F
M
KVF
S
K
G
L
F
T
FL
V
I
L
V
GY
N
A
AQA
FGGT
GVN
G
AI
IA
AL
FLLGY
N
P
AATTGYYA
G
FH-----
-
DF
FGL
PI
---D
P
RGN
I
I
G
V
L
IAA
W
A
C
AR
IE
GM
V
RRFM
P
DDLDMLLT
S
L
IT
LLI
TAT
LA
Y
L
I
I
M
P
L
G
G
W
L
FEG
M
S
WLFMH
L
NS--
-
NPLGC
AV
L
A
G
L
F
LIA
V
V
F
GVH
QGFI
P
VY
L
ALM
--
DSQ
G
FNS
L
F
P
I
L
SM
A
GA
G
Q
fig|478005.5.peg.2508
Escherichia coli O157:H7 str. EC4486 (1-346/474)
MAKEISSELLN
T
I
L
TR
VGG
P
GNI
A
S
CG
N
C
M
TRLR
L
G
V
H
D
SSLVDPD-
IK
TLE
GV
K
GV
IL
T
SD
Q
V
QVV
F
G
PG
K
AH
R
AAK
A
MSELL
G
EAPV
Q
D
AAEIAAQNKRQLKAKQTSG
VQ
QF
L
AKFAT
IF
T
PLIP
GF
I
AA
GLLLG
IAT
LI
--------
A
T
VMHVPADA
Q
G
T
LPDA
L
N
F
M
KVF
S
K
G
L
F
T
FL
V
I
L
V
GY
N
A
AQA
FGGT
GVN
G
AI
IA
AL
FLLGY
N
P
AATTGYYA
G
FH-----
-
DF
FGL
PI
---D
P
RGN
I
I
G
V
L
IAA
W
A
C
AR
IE
GM
V
RRFM
P
DDLDMLLT
S
L
IT
LLI
TAT
LA
Y
L
I
I
M
P
L
G
G
W
L
FEG
M
S
WLFMH
L
NS--
-
NPLGC
AV
L
A
G
L
F
LIA
V
V
F
GVH
QGFI
P
VY
L
ALM
--
DSQ
G
FNS
L
F
P
I
L
SM
A
GA
G
Q
fig|478006.5.peg.1547
Escherichia coli O157:H7 str. EC4501 (1-346/474)
MAKEISSELLN
T
I
L
TR
VGG
P
GNI
A
S
CG
N
C
M
TRLR
L
G
V
H
D
SSLVDPD-
IK
TLE
GV
K
GV
IL
T
SD
Q
V
QVV
F
G
PG
K
AH
R
AAK
A
MSELL
G
EAPV
Q
D
AAEIAAQNKRQLKAKQTSG
VQ
QF
L
AKFAT
IF
T
PLIP
GF
I
AA
GLLLG
IAT
LI
--------
A
T
VMHVPADA
Q
G
T
LPDA
L
N
F
M
KVF
S
K
G
L
F
T
FL
V
I
L
V
GY
N
A
AQA
FGGT
GVN
G
AI
IA
AL
FLLGY
N
P
AATTGYYA
G
FH-----
-
DF
FGL
PI
---D
P
RGN
I
I
G
V
L
IAA
W
A
C
AR
IE
GM
V
RRFM
P
DDLDMLLT
S
L
IT
LLI
TAT
LA
Y
L
I
I
M
P
L
G
G
W
L
FEG
M
S
WLFMH
L
NS--
-
NPLGC
AV
L
A
G
L
F
LIA
V
V
F
GVH
QGFI
P
VY
L
ALM
--
DSQ
G
FNS
L
F
P
I
L
SM
A
GA
G
Q
fig|478007.5.peg.1592
Escherichia coli O157:H7 str. EC508 (1-346/474)
MAKEISSELLN
T
I
L
TR
VGG
P
GNI
A
S
CG
N
C
M
TRLR
L
G
V
H
D
SSLVDPD-
IK
TLE
GV
K
GV
IL
T
SD
Q
V
QVV
F
G
PG
K
AH
R
AAK
A
MSELL
G
EAPV
Q
D
AAEIAAQNKRQLKAKQTSG
VQ
QF
L
AKFAT
IF
T
PLIP
GF
I
AA
GLLLG
IAT
LI
--------
A
T
VMHVPADA
Q
G
T
LPDA
L
N
F
M
KVF
S
K
G
L
F
T
FL
V
I
L
V
GY
N
A
AQA
FGGT
GVN
G
AI
IA
AL
FLLGY
N
P
AATTGYYA
G
FH-----
-
DF
FGL
PI
---D
P
RGN
I
I
G
V
L
IAA
W
A
C
AR
IE
GM
V
RRFM
P
DDLDMLLT
S
L
IT
LLI
TAT
LA
Y
L
I
I
M
P
L
G
G
W
L
FEG
M
S
WLFMH
L
NS--
-
NPLGC
AV
L
A
G
L
F
LIA
V
V
F
GVH
QGFI
P
VY
L
ALM
--
DSQ
G
FNS
L
F
P
I
L
SM
A
GA
G
Q
fig|478008.5.peg.2982
Escherichia coli O157:H7 str. EC869 (1-346/474)
MAKEISSELLN
T
I
L
TR
VGG
P
GNI
A
S
CG
N
C
M
TRLR
L
G
V
H
D
SSLVDPD-
IK
TLE
GV
K
GV
IL
T
SD
Q
V
QVV
F
G
PG
K
AH
R
AAK
A
MSELL
G
EAPV
Q
D
AAEIAAQNKRQLKAKQTSG
VQ
QF
L
AKFAT
IF
T
PLIP
GF
I
AA
GLLLG
IAT
LI
--------
A
T
VMHVPADA
Q
G
T
LPDA
L
N
F
M
KVF
S
K
G
L
F
T
FL
V
I
L
V
GY
N
A
AQA
FGGT
GVN
G
AI
IA
AL
FLLGY
N
P
AATTGYYA
G
FH-----
-
DF
FGL
PI
---D
P
RGN
I
I
G
V
L
IAA
W
A
C
AR
IE
GM
V
RRFM
P
DDLDMLLT
S
L
IT
LLI
TAT
LA
Y
L
I
I
M
P
L
G
G
W
L
FEG
M
S
WLFMH
L
NS--
-
NPLGC
AV
L
A
G
L
F
LIA
V
V
F
GVH
QGFI
P
VY
L
ALM
--
DSQ
G
FNS
L
F
P
I
L
SM
A
GA
G
Q
fig|637388.3.peg.164
Escherichia coli O157:H7 str. FRIK2000 (1-346/474)
MAKEISSELLN
T
I
L
TR
VGG
P
GNI
A
S
CG
N
C
M
TRLR
L
G
V
H
D
SSLVDPD-
IK
TLE
GV
K
GV
IL
T
SD
Q
V
QVV
F
G
PG
K
AH
R
AAK
A
MSELL
G
EAPV
Q
D
AAEIAAQNKRQLKAKQTSG
VQ
QF
L
AKFAT
IF
T
PLIP
GF
I
AA
GLLLG
IAT
LI
--------
A
T
VMHVPADA
Q
G
T
LPDA
L
N
F
M
KVF
S
K
G
L
F
T
FL
V
I
L
V
GY
N
A
AQA
FGGT
GVN
G
AI
IA
AL
FLLGY
N
P
AATTGYYA
G
FH-----
-
DF
FGL
PI
---D
P
RGN
I
I
G
V
L
IAA
W
A
C
AR
IE
GM
V
RRFM
P
DDLDMLLT
S
L
IT
LLI
TAT
LA
Y
L
I
I
M
P
L
G
G
W
L
FEG
M
S
WLFMH
L
NS--
-
NPLGC
AV
L
A
G
L
F
LIA
V
V
F
GVH
QGFI
P
VY
L
ALM
--
DSQ
G
FNS
L
F
P
I
L
SM
A
GA
G
Q
fig|570506.3.peg.5168
Escherichia coli O157:H7 str. FRIK966 (1-346/474)
MAKEISSELLN
T
I
L
TR
VGG
P
GNI
A
S
CG
N
C
M
TRLR
L
G
V
H
D
SSLVDPD-
IK
TLE
GV
K
GV
IL
T
SD
Q
V
QVV
F
G
PG
K
AH
R
AAK
A
MSELL
G
EAPV
Q
D
AAEIAAQNKRQLKAKQTSG
VQ
QF
L
AKFAT
IF
T
PLIP
GF
I
AA
GLLLG
IAT
LI
--------
A
T
VMHVPADA
Q
G
T
LPDA
L
N
F
M
KVF
S
K
G
L
F
T
FL
V
I
L
V
GY
N
A
AQA
FGGT
GVN
G
AI
IA
AL
FLLGY
N
P
AATTGYYA
G
FH-----
-
DF
FGL
PI
---D
P
RGN
I
I
G
V
L
IAA
W
A
C
AR
IE
GM
V
RRFM
P
DDLDMLLT
S
L
IT
LLI
TAT
LA
Y
L
I
I
M
P
L
G
G
W
L
FEG
M
S
WLFMH
L
NS--
-
NPLGC
AV
L
A
G
L
F
LIA
V
V
F
GVH
QGFI
P
VY
L
ALM
--
DSQ
G
FNS
L
F
P
I
L
SM
A
GA
G
Q
fig|386585.9.peg.3447
Escherichia coli O157:H7 str. Sakai (1-346/474)
MAKEISSELLN
T
I
L
TR
VGG
P
GNI
A
S
CG
N
C
M
TRLR
L
G
V
H
D
SSLVDPD-
IK
TLE
GV
K
GV
IL
T
SD
Q
V
QVV
F
G
PG
K
AH
R
AAK
A
MSELL
G
EAPV
Q
D
AAEIAAQNKRQLKAKQTSG
VQ
QF
L
AKFAT
IF
T
PLIP
GF
I
AA
GLLLG
IAT
LI
--------
A
T
VMHVPADA
Q
G
T
LPDA
L
N
F
M
KVF
S
K
G
L
F
T
FL
V
I
L
V
GY
N
A
AQA
FGGT
GVN
G
AI
IA
AL
FLLGY
N
P
AATTGYYA
G
FH-----
-
DF
FGL
PI
---D
P
RGN
I
I
G
V
L
IAA
W
A
C
AR
IE
GM
V
RRFM
P
DDLDMLLT
S
L
IT
LLI
TAT
LA
Y
L
I
I
M
P
L
G
G
W
L
FEG
M
S
WLFMH
L
NS--
-
NPLGC
AV
L
A
G
L
F
LIA
V
V
F
GVH
QGFI
P
VY
L
ALM
--
DSQ
G
FNS
L
F
P
I
L
SM
A
GA
G
Q
fig|544404.4.peg.3430
Escherichia coli O157:H7 str. TW14359 (1-346/474)
MAKEISSELLN
T
I
L
TR
VGG
P
GNI
A
S
CG
N
C
M
TRLR
L
G
V
H
D
SSLVDPD-
IK
TLE
GV
K
GV
IL
T
SD
Q
V
QVV
F
G
PG
K
AH
R
AAK
A
MSELL
G
EAPV
Q
D
AAEIAAQNKRQLKAKQTSG
VQ
QF
L
AKFAT
IF
T
PLIP
GF
I
AA
GLLLG
IAT
LI
--------
A
T
VMHVPADA
Q
G
T
LPDA
L
N
F
M
KVF
S
K
G
L
F
T
FL
V
I
L
V
GY
N
A
AQA
FGGT
GVN
G
AI
IA
AL
FLLGY
N
P
AATTGYYA
G
FH-----
-
DF
FGL
PI
---D
P
RGN
I
I
G
V
L
IAA
W
A
C
AR
IE
GM
V
RRFM
P
DDLDMLLT
S
L
IT
LLI
TAT
LA
Y
L
I
I
M
P
L
G
G
W
L
FEG
M
S
WLFMH
L
NS--
-
NPLGC
AV
L
A
G
L
F
LIA
V
V
F
GVH
QGFI
P
VY
L
ALM
--
DSQ
G
FNS
L
F
P
I
L
SM
A
GA
G
Q
fig|502346.5.peg.3986
Escherichia coli O157:H7 str. TW14588 (1-346/474)
MAKEISSELLN
T
I
L
TR
VGG
P
GNI
A
S
CG
N
C
M
TRLR
L
G
V
H
D
SSLVDPD-
IK
TLE
GV
K
GV
IL
T
SD
Q
V
QVV
F
G
PG
K
AH
R
AAK
A
MSELL
G
EAPV
Q
D
AAEIAAQNKRQLKAKQTSG
VQ
QF
L
AKFAT
IF
T
PLIP
GF
I
AA
GLLLG
IAT
LI
--------
A
T
VMHVPADA
Q
G
T
LPDA
L
N
F
M
KVF
S
K
G
L
F
T
FL
V
I
L
V
GY
N
A
AQA
FGGT
GVN
G
AI
IA
AL
FLLGY
N
P
AATTGYYA
G
FH-----
-
DF
FGL
PI
---D
P
RGN
I
I
G
V
L
IAA
W
A
C
AR
IE
GM
V
RRFM
P
DDLDMLLT
S
L
IT
LLI
TAT
LA
Y
L
I
I
M
P
L
G
G
W
L
FEG
M
S
WLFMH
L
NS--
-
NPLGC
AV
L
A
G
L
F
LIA
V
V
F
GVH
QGFI
P
VY
L
ALM
--
DSQ
G
FNS
L
F
P
I
L
SM
A
GA
G
Q
fig|701177.3.peg.2991
Escherichia coli O55:H7 str. CB9615 (1-346/474)
MAKEISSELLN
T
I
L
TR
VGG
P
GNI
A
S
CG
N
C
M
TRLR
L
G
V
H
D
SSLVDPD-
IK
TLE
GV
K
GV
IL
T
SD
Q
V
QVV
F
G
PG
K
AH
R
AAK
A
MSELL
G
EAPV
Q
D
AAEIAAQNKRQLKAKQTSG
VQ
QF
L
AKFAT
IF
T
PLIP
GF
I
AA
GLLLG
IAT
LI
--------
A
T
VMHVPADA
Q
G
T
LPDA
L
N
F
M
KVF
S
K
G
L
F
T
FL
V
I
L
V
GY
N
A
AQA
FGGT
GVN
G
AI
IA
AL
FLLGY
N
P
AATTGYYA
G
FH-----
-
DF
FGL
PI
---D
P
RGN
I
I
G
V
L
IAA
W
A
C
AR
IE
GM
V
RRFM
P
DDLDMLLT
S
L
IT
LLI
TAT
LA
Y
L
I
I
M
P
L
G
G
W
L
FEG
M
S
WLFMH
L
NS--
-
NPLGC
AV
L
A
G
L
F
LIA
V
V
F
GVH
QGFI
P
VY
L
ALM
--
DSQ
G
FNS
L
F
P
I
L
SM
A
GA
G
Q
fig|585397.7.peg.2880
Escherichia coli ED1a (1-346/474)
MAKEISSELLN
T
I
L
TR
VGG
P
GNI
A
S
CG
N
C
M
TRLR
L
G
V
H
D
SSLVDPD-
IK
TLE
GV
K
GV
IL
T
SD
Q
V
QVV
F
G
PG
K
AH
R
AAK
A
MSELL
G
EAPV
Q
D
AAEIAAQNKRQLKARQTSG
VQ
QF
L
AKFAT
IF
T
PLIP
GF
I
AA
GLLLG
IAT
LI
--------
A
M
VMHVPADA
Q
G
T
LPDA
L
N
F
M
KVF
S
K
G
L
F
T
FL
V
I
L
V
GY
N
A
AQA
FGGT
GVN
G
AI
IA
AL
FLLGY
N
P
AATTGYYA
G
FH-----
-
DF
FGL
PI
---D
P
RGN
I
I
G
V
L
IAA
W
A
C
AR
IE
CM
V
RRFM
P
DDLDMLLT
S
L
IT
LLI
TAT
LA
Y
L
I
I
M
P
L
G
G
W
L
FEG
M
S
WLFMH
L
NS--
-
NPLGC
AV
L
A
G
L
F
LIA
V
V
F
GVH
QGFI
P
VY
L
ALM
--
DSQ
G
FNS
L
F
P
I
L
SM
A
GA
G
Q
fig|481805.3.peg.4601
Escherichia coli ATCC 8739 (7-336/625)
K
I
V
AG
VGG
A
D
NI
V
S
LM
HC
A
TRLRF
K
L
K
D
ESKAQAEV
L
K
KTP
G
I
I
M
V
VE
S
GG
Q
F
QVVIG
NH
V
AD
-
VFL
A
VNSVA
G
LDE-
-
-
KAQQAPENDDKGNLLN---
--
RF
V
YVISG
IF
T
PLI
G
LM
A
AT
G
I
L
K
G
MLA
L
A
--------
L
T
FQWTTEQ-
S
G
T
----
Y
L
I
L
FSA
S
D
A
L
F
W
F
F
PI
I
L
GY
T
A
GKR
FGG
N
PFT
A
MV
I
G
GA
LV
---
HP
LILTAFEN
G
QKADALG
L
DF
LGI
P
V
TLLN
Y
SSS
VIP
I
I
FSA
W
L
C
SI
L
E
RR
L
NAWL
P
SAIKNFFT
PL
LC
L
MV
ITP
VT
F
LL
V
GP
L
S
T
WI
SEL
I
A
AGYLW
L
YQAV
-
PAFAG
AV
M
G
G
F
W
QIF
VM
F
G
L
H
WGLV
P
LC
I
NNF
--
TVL
G
YDT
M
I
PLL
MP
A
IM
AQ
fig|481805.6.peg.4579
Escherichia coli ATCC 8739 (7-336/625)
K
I
V
AG
VGG
A
D
NI
V
S
LM
HC
A
TRLRF
K
L
K
D
ESKAQAEV
L
K
KTP
G
I
I
M
V
VE
S
GG
Q
F
QVVIG
NH
V
AD
-
VFL
A
VNSVA
G
LDE-
-
-
KAQQAPENDDKGNLLN---
--
RF
V
YVISG
IF
T
PLI
G
LM
A
AT
G
I
L
K
G
MLA
L
A
--------
L
T
FQWTTEQ-
S
G
T
----
Y
L
I
L
FSA
S
D
A
L
F
W
F
F
PI
I
L
GY
T
A
GKR
FGG
N
PFT
A
MV
I
G
GA
LV
---
HP
LILTAFEN
G
QKADALG
L
DF
LGI
P
V
TLLN
Y
SSS
VIP
I
I
FSA
W
L
C
SI
L
E
RR
L
NAWL
P
SAIKNFFT
PL
LC
L
MV
ITP
VT
F
LL
V
GP
L
S
T
WI
SEL
I
A
AGYLW
L
YQAV
-
PAFAG
AV
M
G
G
F
W
QIF
VM
F
G
L
H
WGLV
P
LC
I
NNF
--
TVL
G
YDT
M
I
PLL
MP
A
IM
AQ
fig|595496.3.peg.3727
Escherichia coli BW2952 (7-336/625)
K
I
V
AG
VGG
A
D
NI
V
S
LM
HC
A
TRLRF
K
L
K
D
ESKAQAEV
L
K
KTP
G
I
I
M
V
VE
S
GG
Q
F
QVVIG
NH
V
AD
-
VFL
A
VNSVA
G
LDE-
-
-
KAQQAPENDDKGNLLN---
--
RF
V
YVISG
IF
T
PLI
G
LM
A
AT
G
I
L
K
G
MLA
L
A
--------
L
T
FQWTTEQ-
S
G
T
----
Y
L
I
L
FSA
S
D
A
L
F
W
F
F
PI
I
L
GY
T
A
GKR
FGG
N
PFT
A
MV
I
G
GA
LV
---
HP
LILTAFEN
G
QKADALG
L
DF
LGI
P
V
TLLN
Y
SSS
VIP
I
I
FSA
W
L
C
SI
L
E
RR
L
NAWL
P
SAIKNFFT
PL
LC
L
MV
ITP
VT
F
LL
V
GP
L
S
T
WI
SEL
I
A
AGYLW
L
YQAV
-
PAFAG
AV
M
G
G
F
W
QIF
VM
F
G
L
H
WGLV
P
LC
I
NNF
--
TVL
G
YDT
M
I
PLL
MP
A
IM
AQ
fig|536056.3.peg.4517
Escherichia coli DH1 (7-336/625)
K
I
V
AG
VGG
A
D
NI
V
S
LM
HC
A
TRLRF
K
L
K
D
ESKAQAEV
L
K
KTP
G
I
I
M
V
VE
S
GG
Q
F
QVVIG
NH
V
AD
-
VFL
A
VNSVA
G
LDE-
-
-
KAQQAPENDDKGNLLN---
--
RF
V
YVISG
IF
T
PLI
G
LM
A
AT
G
I
L
K
G
MLA
L
A
--------
L
T
FQWTTEQ-
S
G
T
----
Y
L
I
L
FSA
S
D
A
L
F
W
F
F
PI
I
L
GY
T
A
GKR
FGG
N
PFT
A
MV
I
G
GA
LV
---
HP
LILTAFEN
G
QKADALG
L
DF
LGI
P
V
TLLN
Y
SSS
VIP
I
I
FSA
W
L
C
SI
L
E
RR
L
NAWL
P
SAIKNFFT
PL
LC
L
MV
ITP
VT
F
LL
V
GP
L
S
T
WI
SEL
I
A
AGYLW
L
YQAV
-
PAFAG
AV
M
G
G
F
W
QIF
VM
F
G
L
H
WGLV
P
LC
I
NNF
--
TVL
G
YDT
M
I
PLL
MP
A
IM
AQ
fig|656414.3.peg.4253
Escherichia coli H736 (7-336/625)
K
I
V
AG
VGG
A
D
NI
V
S
LM
HC
A
TRLRF
K
L
K
D
ESKAQAEV
L
K
KTP
G
I
I
M
V
VE
S
GG
Q
F
QVVIG
NH
V
AD
-
VFL
A
VNSVA
G
LDE-
-
-
KAQQAPENDDKGNLLN---
--
RF
V
YVISG
IF
T
PLI
G
LM
A
AT
G
I
L
K
G
MLA
L
A
--------
L
T
FQWTTEQ-
S
G
T
----
Y
L
I
L
FSA
S
D
A
L
F
W
F
F
PI
I
L
GY
T
A
GKR
FGG
N
PFT
A
MV
I
G
GA
LV
---
HP
LILTAFEN
G
QKADALG
L
DF
LGI
P
V
TLLN
Y
SSS
VIP
I
I
FSA
W
L
C
SI
L
E
RR
L
NAWL
P
SAIKNFFT
PL
LC
L
MV
ITP
VT
F
LL
V
GP
L
S
T
WI
SEL
I
A
AGYLW
L
YQAV
-
PAFAG
AV
M
G
G
F
W
QIF
VM
F
G
L
H
WGLV
P
LC
I
NNF
--
TVL
G
YDT
M
I
PLL
MP
A
IM
AQ
fig|83333.1.peg.3659
Escherichia coli K12 (7-336/625)
K
I
V
AG
VGG
A
D
NI
V
S
LM
HC
A
TRLRF
K
L
K
D
ESKAQAEV
L
K
KTP
G
I
I
M
V
VE
S
GG
Q
F
QVVIG
NH
V
AD
-
VFL
A
VNSVA
G
LDE-
-
-
KAQQAPENDDKGNLLN---
--
RF
V
YVISG
IF
T
PLI
G
LM
A
AT
G
I
L
K
G
MLA
L
A
--------
L
T
FQWTTEQ-
S
G
T
----
Y
L
I
L
FSA
S
D
A
L
F
W
F
F
PI
I
L
GY
T
A
GKR
FGG
N
PFT
A
MV
I
G
GA
LV
---
HP
LILTAFEN
G
QKADALG
L
DF
LGI
P
V
TLLN
Y
SSS
VIP
I
I
FSA
W
L
C
SI
L
E
RR
L
NAWL
P
SAIKNFFT
PL
LC
L
MV
ITP
VT
F
LL
V
GP
L
S
T
WI
SEL
I
A
AGYLW
L
YQAV
-
PAFAG
AV
M
G
G
F
W
QIF
VM
F
G
L
H
WGLV
P
LC
I
NNF
--
TVL
G
YDT
M
I
PLL
MP
A
IM
AQ
fig|656419.3.peg.4784
Escherichia coli M718 (7-336/625)
K
I
V
AG
VGG
A
D
NI
V
S
LM
HC
A
TRLRF
K
L
K
D
ESKAQAEV
L
K
KTP
G
I
I
M
V
VE
S
GG
Q
F
QVVIG
NH
V
AD
-
VFL
A
VNSVA
G
LDE-
-
-
KAQQAPENDDKGNLLN---
--
RF
V
YVISG
IF
T
PLI
G
LM
A
AT
G
I
L
K
G
MLA
L
A
--------
L
T
FQWTTEQ-
S
G
T
----
Y
L
I
L
FSA
S
D
A
L
F
W
F
F
PI
I
L
GY
T
A
GKR
FGG
N
PFT
A
MV
I
G
GA
LV
---
HP
LILTAFEN
G
QKADALG
L
DF
LGI
P
V
TLLN
Y
SSS
VIP
I
I
FSA
W
L
C
SI
L
E
RR
L
NAWL
P
SAIKNFFT
PL
LC
L
MV
ITP
VT
F
LL
V
GP
L
S
T
WI
SEL
I
A
AGYLW
L
YQAV
-
PAFAG
AV
M
G
G
F
W
QIF
VM
F
G
L
H
WGLV
P
LC
I
NNF
--
TVL
G
YDT
M
I
PLL
MP
A
IM
AQ
fig|749537.3.peg.287
Escherichia coli MS 115-1 (7-336/625)
K
I
V
AG
VGG
A
D
NI
V
S
LM
HC
A
TRLRF
K
L
K
D
ESKAQAEV
L
K
KTP
G
I
I
M
V
VE
S
GG
Q
F
QVVIG
NH
V
AD
-
VFL
A
VNSVA
G
LDE-
-
-
KAQQAPENDDKGNLLN---
--
RF
V
YVISG
IF
T
PLI
G
LM
A
AT
G
I
L
K
G
MLA
L
A
--------
L
T
FQWTTEQ-
S
G
T
----
Y
L
I
L
FSA
S
D
A
L
F
W
F
F
PI
I
L
GY
T
A
GKR
FGG
N
PFT
A
MV
I
G
GA
LV
---
HP
LILTAFEN
G
QKADALG
L
DF
LGI
P
V
TLLN
Y
SSS
VIP
I
I
FSA
W
L
C
SI
L
E
RR
L
NAWL
P
SAIKNFFT
PL
LC
L
MV
ITP
VT
F
LL
V
GP
L
S
T
WI
SEL
I
A
AGYLW
L
YQAV
-
PAFAG
AV
M
G
G
F
W
QIF
VM
F
G
L
H
WGLV
P
LC
I
NNF
--
TVL
G
YDT
M
I
PLL
MP
A
IM
AQ
fig|749538.3.peg.3761
Escherichia coli MS 116-1 (7-336/625)
K
I
V
AG
VGG
A
D
NI
V
S
LM
HC
A
TRLRF
K
L
K
D
ESKAQAEV
L
K
KTP
G
I
I
M
V
VE
S
GG
Q
F
QVVIG
NH
V
AD
-
VFL
A
VNSVA
G
LDE-
-
-
KAQQAPENDDKGNLLN---
--
RF
V
YVISG
IF
T
PLI
G
LM
A
AT
G
I
L
K
G
MLA
L
A
--------
L
T
FQWTTEQ-
S
G
T
----
Y
L
I
L
FSA
S
D
A
L
F
W
F
F
PI
I
L
GY
T
A
GKR
FGG
N
PFT
A
MV
I
G
GA
LV
---
HP
LILTAFEN
G
QKADALG
L
DF
LGI
P
V
TLLN
Y
SSS
VIP
I
I
FSA
W
L
C
SI
L
E
RR
L
NAWL
P
SAIKNFFT
PL
LC
L
MV
ITP
VT
F
LL
V
GP
L
S
T
WI
SEL
I
A
AGYLW
L
YQAV
-
PAFAG
AV
M
G
G
F
W
QIF
VM
F
G
L
H
WGLV
P
LC
I
NNF
--
TVL
G
YDT
M
I
PLL
MP
A
IM
AQ
fig|749540.3.peg.1014
Escherichia coli MS 146-1 (7-336/625)
K
I
V
AG
VGG
A
D
NI
V
S
LM
HC
A
TRLRF
K
L
K
D
ESKAQAEV
L
K
KTP
G
I
I
M
V
VE
S
GG
Q
F
QVVIG
NH
V
AD
-
VFL
A
VNSVA
G
LDE-
-
-
KAQQAPENDDKGNLLN---
--
RF
V
YVISG
IF
T
PLI
G
LM
A
AT
G
I
L
K
G
MLA
L
A
--------
L
T
FQWTTEQ-
S
G
T
----
Y
L
I
L
FSA
S
D
A
L
F
W
F
F
PI
I
L
GY
T
A
GKR
FGG
N
PFT
A
MV
I
G
GA
LV
---
HP
LILTAFEN
G
QKADALG
L
DF
LGI
P
V
TLLN
Y
SSS
VIP
I
I
FSA
W
L
C
SI
L
E
RR
L
NAWL
P
SAIKNFFT
PL
LC
L
MV
ITP
VT
F
LL
V
GP
L
S
T
WI
SEL
I
A
AGYLW
L
YQAV
-
PAFAG
AV
M
G
G
F
W
QIF
VM
F
G
L
H
WGLV
P
LC
I
NNF
--
TVL
G
YDT
M
I
PLL
MP
A
IM
AQ
fig|749544.3.peg.2619
Escherichia coli MS 175-1 (7-336/625)
K
I
V
AG
VGG
A
D
NI
V
S
LM
HC
A
TRLRF
K
L
K
D
ESKAQAEV
L
K
KTP
G
I
I
M
V
VE
S
GG
Q
F
QVVIG
NH
V
AD
-
VFL
A
VNSVA
G
LDE-
-
-
KAQQAPENDDKGNLLN---
--
RF
V
YVISG
IF
T
PLI
G
LM
A
AT
G
I
L
K
G
MLA
L
A
--------
L
T
FQWTTEQ-
S
G
T
----
Y
L
I
L
FSA
S
D
A
L
F
W
F
F
PI
I
L
GY
T
A
GKR
FGG
N
PFT
A
MV
I
G
GA
LV
---
HP
LILTAFEN
G
QKADALG
L
DF
LGI
P
V
TLLN
Y
SSS
VIP
I
I
FSA
W
L
C
SI
L
E
RR
L
NAWL
P
SAIKNFFT
PL
LC
L
MV
ITP
VT
F
LL
V
GP
L
S
T
WI
SEL
I
A
AGYLW
L
YQAV
-
PAFAG
AV
M
G
G
F
W
QIF
VM
F
G
L
H
WGLV
P
LC
I
NNF
--
TVL
G
YDT
M
I
PLL
MP
A
IM
AQ
fig|749548.3.peg.4037
Escherichia coli MS 196-1 (7-336/625)
K
I
V
AG
VGG
A
D
NI
V
S
LM
HC
A
TRLRF
K
L
K
D
ESKAQAEV
L
K
KTP
G
I
I
M
V
VE
S
GG
Q
F
QVVIG
NH
V
AD
-
VFL
A
VNSVA
G
LDE-
-
-
KAQQAPENDDKGNLLN---
--
RF
V
YVISG
IF
T
PLI
G
LM
A
AT
G
I
L
K
G
MLA
L
A
--------
L
T
FQWTTEQ-
S
G
T
----
Y
L
I
L
FSA
S
D
A
L
F
W
F
F
PI
I
L
GY
T
A
GKR
FGG
N
PFT
A
MV
I
G
GA
LV
---
HP
LILTAFEN
G
QKADALG
L
DF
LGI
P
V
TLLN
Y
SSS
VIP
I
I
FSA
W
L
C
SI
L
E
RR
L
NAWL
P
SAIKNFFT
PL
LC
L
MV
ITP
VT
F
LL
V
GP
L
S
T
WI
SEL
I
A
AGYLW
L
YQAV
-
PAFAG
AV
M
G
G
F
W
QIF
VM
F
G
L
H
WGLV
P
LC
I
NNF
--
TVL
G
YDT
M
I
PLL
MP
A
IM
AQ
fig|316407.3.peg.3401
Escherichia coli W3110 (7-336/625)
K
I
V
AG
VGG
A
D
NI
V
S
LM
HC
A
TRLRF
K
L
K
D
ESKAQAEV
L
K
KTP
G
I
I
M
V
VE
S
GG
Q
F
QVVIG
NH
V
AD
-
VFL
A
VNSVA
G
LDE-
-
-
KAQQAPENDDKGNLLN---
--
RF
V
YVISG
IF
T
PLI
G
LM
A
AT
G
I
L
K
G
MLA
L
A
--------
L
T
FQWTTEQ-
S
G
T
----
Y
L
I
L
FSA
S
D
A
L
F
W
F
F
PI
I
L
GY
T
A
GKR
FGG
N
PFT
A
MV
I
G
GA
LV
---
HP
LILTAFEN
G
QKADALG
L
DF
LGI
P
V
TLLN
Y
SSS
VIP
I
I
FSA
W
L
C
SI
L
E
RR
L
NAWL
P
SAIKNFFT
PL
LC
L
MV
ITP
VT
F
LL
V
GP
L
S
T
WI
SEL
I
A
AGYLW
L
YQAV
-
PAFAG
AV
M
G
G
F
W
QIF
VM
F
G
L
H
WGLV
P
LC
I
NNF
--
TVL
G
YDT
M
I
PLL
MP
A
IM
AQ
fig|316385.5.peg.3860
Escherichia coli str. K-12 substr. DH10B (7-336/625)
K
I
V
AG
VGG
A
D
NI
V
S
LM
HC
A
TRLRF
K
L
K
D
ESKAQAEV
L
K
KTP
G
I
I
M
V
VE
S
GG
Q
F
QVVIG
NH
V
AD
-
VFL
A
VNSVA
G
LDE-
-
-
KAQQAPENDDKGNLLN---
--
RF
V
YVISG
IF
T
PLI
G
LM
A
AT
G
I
L
K
G
MLA
L
A
--------
L
T
FQWTTEQ-
S
G
T
----
Y
L
I
L
FSA
S
D
A
L
F
W
F
F
PI
I
L
GY
T
A
GKR
FGG
N
PFT
A
MV
I
G
GA
LV
---
HP
LILTAFEN
G
QKADALG
L
DF
LGI
P
V
TLLN
Y
SSS
VIP
I
I
FSA
W
L
C
SI
L
E
RR
L
NAWL
P
SAIKNFFT
PL
LC
L
MV
ITP
VT
F
LL
V
GP
L
S
T
WI
SEL
I
A
AGYLW
L
YQAV
-
PAFAG
AV
M
G
G
F
W
QIF
VM
F
G
L
H
WGLV
P
LC
I
NNF
--
TVL
G
YDT
M
I
PLL
MP
A
IM
AQ
fig|316385.7.peg.3944
Escherichia coli str. K-12 substr. DH10B (7-336/625)
K
I
V
AG
VGG
A
D
NI
V
S
LM
HC
A
TRLRF
K
L
K
D
ESKAQAEV
L
K
KTP
G
I
I
M
V
VE
S
GG
Q
F
QVVIG
NH
V
AD
-
VFL
A
VNSVA
G
LDE-
-
-
KAQQAPENDDKGNLLN---
--
RF
V
YVISG
IF
T
PLI
G
LM
A
AT
G
I
L
K
G
MLA
L
A
--------
L
T
FQWTTEQ-
S
G
T
----
Y
L
I
L
FSA
S
D
A
L
F
W
F
F
PI
I
L
GY
T
A
GKR
FGG
N
PFT
A
MV
I
G
GA
LV
---
HP
LILTAFEN
G
QKADALG
L
DF
LGI
P
V
TLLN
Y
SSS
VIP
I
I
FSA
W
L
C
SI
L
E
RR
L
NAWL
P
SAIKNFFT
PL
LC
L
MV
ITP
VT
F
LL
V
GP
L
S
T
WI
SEL
I
A
AGYLW
L
YQAV
-
PAFAG
AV
M
G
G
F
W
QIF
VM
F
G
L
H
WGLV
P
LC
I
NNF
--
TVL
G
YDT
M
I
PLL
MP
A
IM
AQ
fig|511145.12.peg.3845
Escherichia coli str. K-12 substr. MG1655 (7-336/625)
K
I
V
AG
VGG
A
D
NI
V
S
LM
HC
A
TRLRF
K
L
K
D
ESKAQAEV
L
K
KTP
G
I
I
M
V
VE
S
GG
Q
F
QVVIG
NH
V
AD
-
VFL
A
VNSVA
G
LDE-
-
-
KAQQAPENDDKGNLLN---
--
RF
V
YVISG
IF
T
PLI
G
LM
A
AT
G
I
L
K
G
MLA
L
A
--------
L
T
FQWTTEQ-
S
G
T
----
Y
L
I
L
FSA
S
D
A
L
F
W
F
F
PI
I
L
GY
T
A
GKR
FGG
N
PFT
A
MV
I
G
GA
LV
---
HP
LILTAFEN
G
QKADALG
L
DF
LGI
P
V
TLLN
Y
SSS
VIP
I
I
FSA
W
L
C
SI
L
E
RR
L
NAWL
P
SAIKNFFT
PL
LC
L
MV
ITP
VT
F
LL
V
GP
L
S
T
WI
SEL
I
A
AGYLW
L
YQAV
-
PAFAG
AV
M
G
G
F
W
QIF
VM
F
G
L
H
WGLV
P
LC
I
NNF
--
TVL
G
YDT
M
I
PLL
MP
A
IM
AQ
fig|511145.6.peg.3827
Escherichia coli str. K-12 substr. MG1655 (7-336/625)
K
I
V
AG
VGG
A
D
NI
V
S
LM
HC
A
TRLRF
K
L
K
D
ESKAQAEV
L
K
KTP
G
I
I
M
V
VE
S
GG
Q
F
QVVIG
NH
V
AD
-
VFL
A
VNSVA
G
LDE-
-
-
KAQQAPENDDKGNLLN---
--
RF
V
YVISG
IF
T
PLI
G
LM
A
AT
G
I
L
K
G
MLA
L
A
--------
L
T
FQWTTEQ-
S
G
T
----
Y
L
I
L
FSA
S
D
A
L
F
W
F
F
PI
I
L
GY
T
A
GKR
FGG
N
PFT
A
MV
I
G
GA
LV
---
HP
LILTAFEN
G
QKADALG
L
DF
LGI
P
V
TLLN
Y
SSS
VIP
I
I
FSA
W
L
C
SI
L
E
RR
L
NAWL
P
SAIKNFFT
PL
LC
L
MV
ITP
VT
F
LL
V
GP
L
S
T
WI
SEL
I
A
AGYLW
L
YQAV
-
PAFAG
AV
M
G
G
F
W
QIF
VM
F
G
L
H
WGLV
P
LC
I
NNF
--
TVL
G
YDT
M
I
PLL
MP
A
IM
AQ
fig|216593.1.peg.4533
Escherichia coli E2348/69 (21-345/633)
VGG
A
D
NI
V
S
LM
HC
A
TRLRF
K
L
K
D
ESKAQAEV
L
K
KTP
G
I
I
M
V
VE
S
GG
Q
F
QVVIG
NH
V
AD
-
VFL
A
VNSVA
G
LGE-
-
-
KAQQAPENDDKGNLLN---
--
RF
V
YVISG
IF
T
PLI
G
LM
A
AT
G
I
L
K
G
MLA
L
A
--------
L
T
FQWTTEQ-
S
G
T
----
Y
L
I
L
FSA
S
D
A
L
F
W
F
F
PI
I
L
GY
T
A
GKR
F
S
G
N
PFT
A
MV
I
G
GA
LV
---
HP
LILTAFEN
G
QKVDALG
L
DF
LGI
P
V
TLLN
Y
SSS
VIP
I
I
FSA
W
L
C
SI
L
E
RR
L
NAWL
P
SAIKNFFT
PL
LC
L
MV
ITP
I
T
F
LL
V
GP
L
S
T
WI
SEL
I
A
AGYLW
L
YQAV
-
SAFAG
AV
M
G
G
F
W
QIF
VM
F
G
L
H
WGLI
P
LI
I
NNF
--
TVL
G
YDT
M
I
PLL
MP
A
IM
AQ
fig|574521.7.peg.4111
Escherichia coli O127:H6 str. E2348/69 (12-336/624)
VGG
A
D
NI
V
S
LM
HC
A
TRLRF
K
L
K
D
ESKAQAEV
L
K
KTP
G
I
I
M
V
VE
S
GG
Q
F
QVVIG
NH
V
AD
-
VFL
A
VNSVA
G
LGE-
-
-
KAQQAPENDDKGNLLN---
--
RF
V
YVISG
IF
T
PLI
G
LM
A
AT
G
I
L
K
G
MLA
L
A
--------
L
T
FQWTTEQ-
S
G
T
----
Y
L
I
L
FSA
S
D
A
L
F
W
F
F
PI
I
L
GY
T
A
GKR
F
S
G
N
PFT
A
MV
I
G
GA
LV
---
HP
LILTAFEN
G
QKVDALG
L
DF
LGI
P
V
TLLN
Y
SSS
VIP
I
I
FSA
W
L
C
SI
L
E
RR
L
NAWL
P
SAIKNFFT
PL
LC
L
MV
ITP
I
T
F
LL
V
GP
L
S
T
WI
SEL
I
A
AGYLW
L
YQAV
-
SAFAG
AV
M
G
G
F
W
QIF
VM
F
G
L
H
WGLI
P
LI
I
NNF
--
TVL
G
YDT
M
I
PLL
MP
A
IM
AQ
fig|670897.3.peg.3393
Escherichia coli 2362-75 (1-346/474)
MAKEISSELLN
T
I
L
TR
VGG
P
GNI
A
S
CG
N
C
M
TRLR
L
G
V
H
D
SSLVDPN-
IK
TLE
GV
K
GV
IL
T
SD
Q
V
QVV
F
G
PG
K
AH
R
AAK
A
MSELL
G
EAPV
Q
D
AAEIAAQNKRQLKAKQTSG
VQ
QF
L
AKFAT
IF
T
PLIP
GF
I
AA
GLLLG
IAT
LI
--------
A
T
VMHVPADA
Q
G
T
LPDA
L
N
F
M
KVF
S
K
G
L
F
T
FL
V
I
L
V
GY
N
A
AQA
FGGT
GVN
G
AI
IA
AL
FLLGY
N
P
TATTGYYA
G
FH-----
-
DF
FGL
PI
---D
P
RGN
I
I
G
V
L
IAA
W
A
C
AR
IE
GM
V
RRFM
P
DDLDMLLT
S
L
IT
LLI
TAT
LA
Y
L
I
I
M
P
L
G
G
W
L
FEG
M
S
WLFMH
L
NS--
-
NPLGC
AV
L
A
G
L
F
LIA
V
V
F
GVH
QGFI
P
VY
L
ALM
--
DSQ
G
FNS
L
F
P
I
L
SM
A
GA
G
Q
fig|550677.3.peg.2015
Escherichia coli B354 (1-346/474)
MAKEISSELLN
T
I
L
TR
VGG
P
GNI
A
S
CG
N
C
M
TRLR
L
G
V
H
D
SSLVDPN-
IK
TLE
GV
K
GV
IL
T
SD
Q
V
QVV
F
G
PG
K
AH
R
AAK
A
MSELL
G
EAPV
Q
D
AAEIAAQNKRQLKAKQTSG
VQ
QF
L
AKFAT
IF
T
PLIP
GF
I
AA
GLLLG
IAT
LI
--------
A
T
VMHVPADA
Q
G
T
LPDA
L
N
F
M
KVF
S
K
G
L
F
T
FL
V
I
L
V
GY
N
A
AQA
FGGT
GVN
G
AI
IA
AL
FLLGY
N
P
TATTGYYA
G
FH-----
-
DF
FGL
PI
---D
P
RGN
I
I
G
V
L
IAA
W
A
C
AR
IE
GM
V
RRFM
P
DDLDMLLT
S
L
IT
LLI
TAT
LA
Y
L
I
I
M
P
L
G
G
W
L
FEG
M
S
WLFMH
L
NS--
-
NPLGC
AV
L
A
G
L
F
LIA
V
V
F
GVH
QGFI
P
VY
L
ALM
--
DSQ
G
FNS
L
F
P
I
L
SM
A
GA
G
Q
fig|685038.3.peg.2473
Escherichia coli O83:H1 str. NRG 857C (1-346/474)
MAKEISSELLN
T
I
L
TR
VGG
P
GNI
A
S
CG
N
C
M
TRLR
L
G
V
H
D
SSLVDPD-
IK
TLE
GV
K
GV
IL
T
SD
Q
V
QVV
F
G
PG
K
AH
R
AAK
A
MSELL
G
EAPV
Q
D
AAEIAAQNKRQLKARQTSG
VQ
QF
L
AKFAT
IF
T
PLIP
GF
I
AA
GLLLG
IAT
LI
--------
A
T
VMHVTADA
Q
G
T
LPDA
L
N
F
M
KVF
S
K
G
L
F
T
FL
V
I
L
V
GY
N
A
AQA
FGGT
GVN
G
AI
IA
AL
FLLGY
N
P
TATTGYYA
G
FH-----
-
DF
FGL
PI
---D
P
RGN
I
I
G
V
L
IAA
W
A
C
AR
IE
CM
V
RRFM
P
DDLDMLLT
S
L
IT
LLI
TAT
LA
Y
L
I
I
M
P
L
G
G
W
L
FEA
M
S
WLFMH
L
NS--
-
NPLGC
AV
L
A
G
L
F
LIA
V
V
F
GVH
QGFI
P
VY
L
ALM
--
DSQ
G
FNS
L
F
P
I
L
SM
A
GA
G
Q
fig|216592.1.peg.5470
Escherichia coli 042 (1-346/474)
MAKEISSELLN
T
I
L
TR
VGG
P
GNI
A
S
CG
N
C
M
TRLR
L
G
V
H
D
SSLVDPN-
IK
TLE
GV
K
GV
IL
T
SD
Q
V
QVV
F
G
PG
K
AH
R
AAK
A
MSELL
G
EAPV
Q
D
AAEIAAQNKRQLKAKQTSG
VQ
QF
L
AKFAT
IF
T
PLIP
GF
I
AA
GLLLG
IAT
LI
--------
A
T
VMHVPADA
Q
G
T
LPDA
L
N
F
M
KVF
S
K
G
L
F
T
FL
V
I
L
V
GY
N
A
AQA
FGGT
GVN
G
AI
IA
AL
FLLGY
N
P
AATTGYYA
G
FH-----
-
DF
FGL
PI
---D
P
RGN
I
I
G
V
L
IAA
W
A
C
AR
IE
GM
V
RRFM
P
DDLDMLLT
S
L
IT
LLI
TAT
LA
Y
L
I
I
M
P
L
G
G
W
L
FEG
M
S
WLFMH
L
NS--
-
NPLGC
AV
L
A
G
L
F
LIA
V
V
F
GVH
QGFI
P
VY
L
ALM
--
DSQ
G
FNS
L
F
P
I
L
SM
A
GA
G
Q
fig|216592.3.peg.2760
Escherichia coli 042 (1-346/474)
MAKEISSELLN
T
I
L
TR
VGG
P
GNI
A
S
CG
N
C
M
TRLR
L
G
V
H
D
SSLVDPN-
IK
TLE
GV
K
GV
IL
T
SD
Q
V
QVV
F
G
PG
K
AH
R
AAK
A
MSELL
G
EAPV
Q
D
AAEIAAQNKRQLKAKQTSG
VQ
QF
L
AKFAT
IF
T
PLIP
GF
I
AA
GLLLG
IAT
LI
--------
A
T
VMHVPADA
Q
G
T
LPDA
L
N
F
M
KVF
S
K
G
L
F
T
FL
V
I
L
V
GY
N
A
AQA
FGGT
GVN
G
AI
IA
AL
FLLGY
N
P
AATTGYYA
G
FH-----
-
DF
FGL
PI
---D
P
RGN
I
I
G
V
L
IAA
W
A
C
AR
IE
GM
V
RRFM
P
DDLDMLLT
S
L
IT
LLI
TAT
LA
Y
L
I
I
M
P
L
G
G
W
L
FEG
M
S
WLFMH
L
NS--
-
NPLGC
AV
L
A
G
L
F
LIA
V
V
F
GVH
QGFI
P
VY
L
ALM
--
DSQ
G
FNS
L
F
P
I
L
SM
A
GA
G
Q
fig|1040638.4.peg.2844
Escherichia coli O104:H4 str. LB226692 (1-346/474)
MAKEISSELLN
T
I
L
TR
VGG
P
GNI
A
S
CG
N
C
M
TRLR
L
G
V
H
D
SSLVDPN-
IK
TLE
GV
K
GV
IL
T
SD
Q
V
QVV
F
G
PG
K
AH
R
AAK
A
MSELL
G
EAPV
Q
D
AAEIAAQNKRQLKAKQTSG
VQ
QF
L
AKFAT
IF
T
PLIP
GF
I
AA
GLLLG
IAT
LI
--------
A
T
VMHVPADA
Q
G
T
LPDA
L
N
F
M
KVF
S
KS
L
F
T
FL
V
I
L
V
GY
N
A
AQA
FGGT
GVN
G
AI
IA
AL
FLLGY
N
P
AATTGYYA
G
FH-----
-
DF
FGL
PI
---D
P
RGN
I
I
G
V
L
IAA
W
A
C
AR
IE
GM
V
RRFM
P
DDLDMLLT
S
L
IT
LLI
TAT
LA
Y
L
I
I
M
P
L
G
G
W
L
FEG
M
S
WLFMH
L
NS--
-
NPFGC
AV
L
A
G
L
F
LIA
V
V
F
GVH
QGFI
P
VY
L
ALM
--
DSQ
G
FNS
L
F
P
I
L
SM
A
GA
G
Q
fig|6666666.5357.peg.4675
Escherichia coli TY-2482 (1-346/474)
MAKEISSELLN
T
I
L
TR
VGG
P
GNI
A
S
CG
N
C
M
TRLR
L
G
V
H
D
SSLVDPN-
IK
TLE
GV
K
GV
IL
T
SD
Q
V
QVV
F
G
PG
K
AH
R
AAK
A
MSELL
G
EAPV
Q
D
AAEIAAQNKRQLKAKQTSG
VQ
QF
L
AKFAT
IF
T
PLIP
GF
I
AA
GLLLG
IAT
LI
--------
A
T
VMHVPADA
Q
G
T
LPDA
L
N
F
M
KVF
S
KS
L
F
T
FL
V
I
L
V
GY
N
A
AQA
FGGT
GVN
G
AI
IA
AL
FLLGY
N
P
AATTGYYA
G
FH-----
-
DF
FGL
PI
---D
P
RGN
I
I
G
V
L
IAA
W
A
C
AR
IE
GM
V
RRFM
P
DDLDMLLT
S
L
IT
LLI
TAT
LA
Y
L
I
I
M
P
L
G
G
W
L
FEG
M
S
WLFMH
L
NS--
-
NPFGC
AV
L
A
G
L
F
LIA
V
V
F
GVH
QGFI
P
VY
L
ALM
--
DSQ
G
FNS
L
F
P
I
L
SM
A
GA
G
Q
fig|585055.6.peg.2747
Escherichia coli 55989 (1-346/474)
MAKEISSELLN
T
I
L
TR
VGG
P
GNI
A
S
CG
N
C
M
TRLR
L
G
V
H
D
SSLVDPN-
IK
TLE
GV
K
GV
IL
T
SD
Q
V
QVV
F
G
PG
K
AH
R
AAK
A
MSELL
G
EAPV
Q
D
AAEIAAQNKRQLKAKQTSG
VQ
QF
L
AKFAT
IF
T
PLIP
GF
I
AA
GLLLG
IAT
LI
--------
A
T
VMHVPADA
Q
G
T
LPDA
L
N
F
M
KVF
S
KS
L
F
T
FL
V
I
L
V
GY
N
A
AQA
FGGT
GVN
G
AI
IA
AL
FLLGY
N
P
AATTGYYA
G
FH-----
-
DF
FGL
PI
---D
P
RGN
I
I
G
V
L
IAA
W
A
C
AR
IE
GM
V
RRFM
P
DDLDMLLT
S
L
IT
LLI
TAT
LA
Y
L
I
I
M
P
L
G
G
W
L
FEG
M
S
WLFMH
L
NS--
-
NPFGC
AV
L
A
G
L
F
LIA
V
V
F
GVH
QGFI
P
VY
L
ALM
--
DSQ
G
FNS
L
F
P
I
L
SM
A
GA
G
Q
fig|585055.8.peg.2752
Escherichia coli 55989 (1-346/474)
MAKEISSELLN
T
I
L
TR
VGG
P
GNI
A
S
CG
N
C
M
TRLR
L
G
V
H
D
SSLVDPN-
IK
TLE
GV
K
GV
IL
T
SD
Q
V
QVV
F
G
PG
K
AH
R
AAK
A
MSELL
G
EAPV
Q
D
AAEIAAQNKRQLKAKQTSG
VQ
QF
L
AKFAT
IF
T
PLIP
GF
I
AA
GLLLG
IAT
LI
--------
A
T
VMHVPADA
Q
G
T
LPDA
L
N
F
M
KVF
S
KS
L
F
T
FL
V
I
L
V
GY
N
A
AQA
FGGT
GVN
G
AI
IA
AL
FLLGY
N
P
AATTGYYA
G
FH-----
-
DF
FGL
PI
---D
P
RGN
I
I
G
V
L
IAA
W
A
C
AR
IE
GM
V
RRFM
P
DDLDMLLT
S
L
IT
LLI
TAT
LA
Y
L
I
I
M
P
L
G
G
W
L
FEG
M
S
WLFMH
L
NS--
-
NPFGC
AV
L
A
G
L
F
LIA
V
V
F
GVH
QGFI
P
VY
L
ALM
--
DSQ
G
FNS
L
F
P
I
L
SM
A
GA
G
Q
fig|340184.3.peg.4102
Escherichia coli B7A (1-346/474)
MAKEISSELLN
T
I
L
TR
VGG
P
GNI
A
S
CG
N
C
M
TRLR
L
G
V
H
D
SSLVDPN-
IK
TLE
GV
K
GV
IL
T
SD
Q
V
QVV
F
G
PG
K
AH
R
AAK
A
MSELL
G
EAPV
Q
D
AAEIAAQNKRQLKAKQTSG
VQ
QF
L
AKFAT
IF
T
PLIP
GF
I
AA
GLLLG
IAT
LI
--------
A
T
VMHVPADA
Q
G
T
LPDA
L
N
F
M
KVF
S
K
G
L
F
T
FL
V
I
L
V
GY
N
A
AQA
FGGT
GVN
G
AI
IA
AL
FLLGY
N
P
AATTGYYA
G
FH-----
-
DF
FGL
PI
---D
P
RGN
I
I
G
V
L
IAA
W
A
C
AR
IE
GM
V
RRFM
P
DDLDMLLT
S
L
IT
LLI
TAT
LA
Y
L
I
I
M
P
L
G
G
W
L
FEG
M
S
WLFMH
L
NS--
-
NPLGC
AV
L
A
G
L
F
LIA
V
V
F
GVH
QGFI
P
VY
L
ALM
--
DSQ
G
FNS
L
F
P
I
L
SM
A
GA
G
Q
fig|340184.6.peg.4295
Escherichia coli B7A (1-346/474)
MAKEISSELLN
T
I
L
TR
VGG
P
GNI
A
S
CG
N
C
M
TRLR
L
G
V
H
D
SSLVDPN-
IK
TLE
GV
K
GV
IL
T
SD
Q
V
QVV
F
G
PG
K
AH
R
AAK
A
MSELL
G
EAPV
Q
D
AAEIAAQNKRQLKAKQTSG
VQ
QF
L
AKFAT
IF
T
PLIP
GF
I
AA
GLLLG
IAT
LI
--------
A
T
VMHVPADA
Q
G
T
LPDA
L
N
F
M
KVF
S
K
G
L
F
T
FL
V
I
L
V
GY
N
A
AQA
FGGT
GVN
G
AI
IA
AL
FLLGY
N
P
AATTGYYA
G
FH-----
-
DF
FGL
PI
---D
P
RGN
I
I
G
V
L
IAA
W
A
C
AR
IE
GM
V
RRFM
P
DDLDMLLT
S
L
IT
LLI
TAT
LA
Y
L
I
I
M
P
L
G
G
W
L
FEG
M
S
WLFMH
L
NS--
-
NPLGC
AV
L
A
G
L
F
LIA
V
V
F
GVH
QGFI
P
VY
L
ALM
--
DSQ
G
FNS
L
F
P
I
L
SM
A
GA
G
Q
fig|656379.3.peg.3007
Escherichia coli FVEC1302 (1-346/474)
MAKEISSELLN
T
I
L
TR
VGG
P
GNI
A
S
CG
N
C
M
TRLR
L
G
V
H
D
SSLVDPN-
IK
TLE
GV
K
GV
IL
T
SD
Q
V
QVV
F
G
PG
K
AH
R
AAK
A
MSELL
G
EAPV
Q
D
AAEIAAQNKRQLKAKQTSG
VQ
QF
L
AKFAT
IF
T
PLIP
GF
I
AA
GLLLG
IAT
LI
--------
A
T
VMHVPADA
Q
G
T
LPDA
L
N
F
M
KVF
S
K
G
L
F
T
FL
V
I
L
V
GY
N
A
AQA
FGGT
GVN
G
AI
IA
AL
FLLGY
N
P
AATTGYYA
G
FH-----
-
DF
FGL
PI
---D
P
RGN
I
I
G
V
L
IAA
W
A
C
AR
IE
GM
V
RRFM
P
DDLDMLLT
S
L
IT
LLI
TAT
LA
Y
L
I
I
M
P
L
G
G
W
L
FEG
M
S
WLFMH
L
NS--
-
NPLGC
AV
L
A
G
L
F
LIA
V
V
F
GVH
QGFI
P
VY
L
ALM
--
DSQ
G
FNS
L
F
P
I
L
SM
A
GA
G
Q
fig|656380.3.peg.2508
Escherichia coli FVEC1412 (1-346/474)
MAKEISSELLN
T
I
L
TR
VGG
P
GNI
A
S
CG
N
C
M
TRLR
L
G
V
H
D
SSLVDPN-
IK
TLE
GV
K
GV
IL
T
SD
Q
V
QVV
F
G
PG
K
AH
R
AAK
A
MSELL
G
EAPV
Q
D
AAEIAAQNKRQLKAKQTSG
VQ
QF
L
AKFAT
IF
T
PLIP
GF
I
AA
GLLLG
IAT
LI
--------
A
T
VMHVPADA
Q
G
T
LPDA
L
N
F
M
KVF
S
K
G
L
F
T
FL
V
I
L
V
GY
N
A
AQA
FGGT
GVN
G
AI
IA
AL
FLLGY
N
P
AATTGYYA
G
FH-----
-
DF
FGL
PI
---D
P
RGN
I
I
G
V
L
IAA
W
A
C
AR
IE
GM
V
RRFM
P
DDLDMLLT
S
L
IT
LLI
TAT
LA
Y
L
I
I
M
P
L
G
G
W
L
FEG
M
S
WLFMH
L
NS--
-
NPLGC
AV
L
A
G
L
F
LIA
V
V
F
GVH
QGFI
P
VY
L
ALM
--
DSQ
G
FNS
L
F
P
I
L
SM
A
GA
G
Q
fig|656393.3.peg.3450
Escherichia coli H299 (1-346/474)
MAKEISSELLN
T
I
L
TR
VGG
P
GNI
A
S
CG
N
C
M
TRLR
L
G
V
H
D
SSLVDPN-
IK
TLE
GV
K
GV
IL
T
SD
Q
V
QVV
F
G
PG
K
AH
R
AAK
A
MSELL
G
EAPV
Q
D
AAEIAAQNKRQLKAKQTSG
VQ
QF
L
AKFAT
IF
T
PLIP
GF
I
AA
GLLLG
IAT
LI
--------
A
T
VMHVPADA
Q
G
T
LPDA
L
N
F
M
KVF
S
K
G
L
F
T
FL
V
I
L
V
GY
N
A
AQA
FGGT
GVN
G
AI
IA
AL
FLLGY
N
P
AATTGYYA
G
FH-----
-
DF
FGL
PI
---D
P
RGN
I
I
G
V
L
IAA
W
A
C
AR
IE
GM
V
RRFM
P
DDLDMLLT
S
L
IT
LLI
TAT
LA
Y
L
I
I
M
P
L
G
G
W
L
FEG
M
S
WLFMH
L
NS--
-
NPLGC
AV
L
A
G
L
F
LIA
V
V
F
GVH
QGFI
P
VY
L
ALM
--
DSQ
G
FNS
L
F
P
I
L
SM
A
GA
G
Q
fig|679204.3.peg.1665
Escherichia coli MS 145-7 (1-346/474)
MAKEISSELLN
T
I
L
TR
VGG
P
GNI
A
S
CG
N
C
M
TRLR
L
G
V
H
D
SSLVDPN-
IK
TLE
GV
K
GV
IL
T
SD
Q
V
QVV
F
G
PG
K
AH
R
AAK
A
MSELL
G
EAPV
Q
D
AAEIAAQNKRQLKAKQTSG
VQ
QF
L
AKFAT
IF
T
PLIP
GF
I
AA
GLLLG
IAT
LI
--------
A
T
VMHVPADA
Q
G
T
LPDA
L
N
F
M
KVF
S
K
G
L
F
T
FL
V
I
L
V
GY
N
A
AQA
FGGT
GVN
G
AI
IA
AL
FLLGY
N
P
AATTGYYA
G
FH-----
-
DF
FGL
PI
---D
P
RGN
I
I
G
V
L
IAA
W
A
C
AR
IE
GM
V
RRFM
P
DDLDMLLT
S
L
IT
LLI
TAT
LA
Y
L
I
I
M
P
L
G
G
W
L
FEG
M
S
WLFMH
L
NS--
-
NPLGC
AV
L
A
G
L
F
LIA
V
V
F
GVH
QGFI
P
VY
L
ALM
--
DSQ
G
FNS
L
F
P
I
L
SM
A
GA
G
Q
fig|749549.3.peg.1380
Escherichia coli MS 198-1 (1-346/474)
MAKEISSELLN
T
I
L
TR
VGG
P
GNI
A
S
CG
N
C
M
TRLR
L
G
V
H
D
SSLVDPN-
IK
TLE
GV
K
GV
IL
T
SD
Q
V
QVV
F
G
PG
K
AH
R
AAK
A
MSELL
G
EAPV
Q
D
AAEIAAQNKRQLKAKQTSG
VQ
QF
L
AKFAT
IF
T
PLIP
GF
I
AA
GLLLG
IAT
LI
--------
A
T
VMHVPADA
Q
G
T
LPDA
L
N
F
M
KVF
S
K
G
L
F
T
FL
V
I
L
V
GY
N
A
AQA
FGGT
GVN
G
AI
IA
AL
FLLGY
N
P
AATTGYYA
G
FH-----
-
DF
FGL
PI
---D
P
RGN
I
I
G
V
L
IAA
W
A
C
AR
IE
GM
V
RRFM
P
DDLDMLLT
S
L
IT
LLI
TAT
LA
Y
L
I
I
M
P
L
G
G
W
L
FEG
M
S
WLFMH
L
NS--
-
NPLGC
AV
L
A
G
L
F
LIA
V
V
F
GVH
QGFI
P
VY
L
ALM
--
DSQ
G
FNS
L
F
P
I
L
SM
A
GA
G
Q
fig|656437.3.peg.2758
Escherichia coli TA143 (1-346/474)
MAKEISSELLN
T
I
L
TR
VGG
P
GNI
A
S
CG
N
C
M
TRLR
L
G
V
H
D
SSLVDPN-
IK
TLE
GV
K
GV
IL
T
SD
Q
V
QVV
F
G
PG
K
AH
R
AAK
A
MSELL
G
EAPV
Q
D
AAEIAAQNKRQLKAKQTSG
VQ
QF
L
AKFAT
IF
T
PLIP
GF
I
AA
GLLLG
IAT
LI
--------
A
T
VMHVPADA
Q
G
T
LPDA
L
N
F
M
KVF
S
K
G
L
F
T
FL
V
I
L
V
GY
N
A
AQA
FGGT
GVN
G
AI
IA
AL
FLLGY
N
P
AATTGYYA
G
FH-----
-
DF
FGL
PI
---D
P
RGN
I
I
G
V
L
IAA
W
A
C
AR
IE
GM
V
RRFM
P
DDLDMLLT
S
L
IT
LLI
TAT
LA
Y
L
I
I
M
P
L
G
G
W
L
FEG
M
S
WLFMH
L
NS--
-
NPLGC
AV
L
A
G
L
F
LIA
V
V
F
GVH
QGFI
P
VY
L
ALM
--
DSQ
G
FNS
L
F
P
I
L
SM
A
GA
G
Q
fig|585056.7.peg.2931
Escherichia coli UMN026 (1-346/474)
MAKEISSELLN
T
I
L
TR
VGG
P
GNI
A
S
CG
N
C
M
TRLR
L
G
V
H
D
SSLVDPN-
IK
TLE
GV
K
GV
IL
T
SD
Q
V
QVV
F
G
PG
K
AH
R
AAK
A
MSELL
G
EAPV
Q
D
AAEIAAQNKRQLKAKQTSG
VQ
QF
L
AKFAT
IF
T
PLIP
GF
I
AA
GLLLG
IAT
LI
--------
A
T
VMHVPADA
Q
G
T
LPDA
L
N
F
M
KVF
S
K
G
L
F
T
FL
V
I
L
V
GY
N
A
AQA
FGGT
GVN
G
AI
IA
AL
FLLGY
N
P
AATTGYYA
G
FH-----
-
DF
FGL
PI
---D
P
RGN
I
I
G
V
L
IAA
W
A
C
AR
IE
GM
V
RRFM
P
DDLDMLLT
S
L
IT
LLI
TAT
LA
Y
L
I
I
M
P
L
G
G
W
L
FEG
M
S
WLFMH
L
NS--
-
NPLGC
AV
L
A
G
L
F
LIA
V
V
F
GVH
QGFI
P
VY
L
ALM
--
DSQ
G
FNS
L
F
P
I
L
SM
A
GA
G
Q
fig|749527.3.peg.4810
Escherichia coli MS 21-1 (1-346/474)
MAKEISSELLN
T
I
L
TR
VGG
P
GNI
A
S
CG
N
C
M
TRLR
L
G
V
H
D
SSLVDPN-
IK
TLE
GV
K
GV
IL
T
SD
Q
V
QVV
F
G
PG
K
AH
R
AAK
A
MSELL
G
EAPI
Q
D
AAEIAAQNKRQLKARQTSG
VQ
QF
L
AKFAT
IF
T
PLIP
GF
I
AA
GLLLG
IAT
LI
--------
A
T
VMHVPADA
Q
G
T
LPDA
L
N
F
M
KVF
S
K
G
L
F
T
FL
V
I
L
V
GY
N
A
AQA
FGGT
GVN
G
AI
IA
AL
FLLGY
N
P
TATTGYYA
G
FH-----
-
DF
FGL
PI
---D
P
RGN
I
I
G
V
L
IAA
W
A
C
AR
IE
GM
V
RRFM
P
DDLDMLLT
S
L
IT
LLI
TAT
LA
Y
L
I
I
M
P
L
G
G
W
L
FEG
M
S
WLFMH
L
NS--
-
NPLGC
AV
L
A
G
L
F
LIA
V
V
F
GVH
QGFI
P
VY
L
ALM
--
DSQ
G
FNS
L
F
P
I
L
SM
A
GA
G
Q
fig|670897.3.peg.3541
Escherichia coli 2362-75 (12-336/624)
VGG
A
D
NI
V
S
LM
HC
A
TRLRF
K
L
K
D
ESKAQAEV
L
K
KTP
G
I
I
M
V
VE
S
GG
Q
F
QVVIG
NH
V
AD
-
VFL
A
VNSVA
G
LGE-
-
-
KAQQAPENDDKGNLLN---
--
RF
V
YVISG
IF
T
PLI
G
LM
A
AT
G
I
L
K
G
MLA
L
A
--------
L
T
FQWTTEQ-
S
G
T
----
Y
L
I
L
FSA
S
D
A
L
F
W
F
F
PI
I
L
GY
T
A
GKR
F
S
G
N
PFT
A
MV
I
G
GA
LV
---
HP
LILTAFEN
G
QKVDALG
L
DF
LGI
P
V
TLLN
Y
SSS
VIP
I
I
FSA
W
L
C
SI
L
E
RR
L
NAWL
P
SAIKNFFT
PL
LC
L
MV
ITP
I
T
F
LL
V
GP
L
S
T
WI
SEL
I
A
AGYLW
L
YQAV
-
PAFAG
AV
M
G
G
F
W
QIF
VM
F
G
L
H
WGLI
P
LI
I
NNF
--
TVL
G
YDT
M
I
PLL
MP
A
IM
AQ
fig|525281.3.peg.3220
Escherichia coli 83972 (12-336/624)
VGG
A
D
NI
V
S
LM
HC
A
TRLRF
K
L
K
D
ESKAQAEV
L
K
KTP
G
I
I
M
V
VE
S
GG
Q
F
QVVIG
NH
V
AD
-
VFL
A
VNSVA
G
LGE-
-
-
KAQQAPENDDKGNLLN---
--
RF
V
YVISG
IF
T
PLI
G
LM
A
AT
G
I
L
K
G
MLA
L
A
--------
L
T
FQWTTEQ-
S
G
T
----
Y
L
I
L
FSA
S
D
A
L
F
W
F
F
PI
I
L
GY
T
A
GKR
F
S
G
N
PFT
A
MV
I
G
GA
LV
---
HP
LILTAFEN
G
QKVDALG
L
DF
LGI
P
V
TLLN
Y
SSS
VIP
I
I
FSA
W
L
C
SI
L
E
RR
L
NAWL
P
SAIKNFFT
PL
LC
L
MV
ITP
I
T
F
LL
V
GP
L
S
T
WI
SEL
I
A
AGYLW
L
YQAV
-
PAFAG
AV
M
G
G
F
W
QIF
VM
F
G
L
H
WGLI
P
LI
I
NNF
--
TVL
G
YDT
M
I
PLL
MP
A
IM
AQ
fig|199310.4.peg.4361
Escherichia coli CFT073 (12-336/624)
VGG
A
D
NI
V
S
LM
HC
A
TRLRF
K
L
K
D
ESKAQAEV
L
K
KTP
G
I
I
M
V
VE
S
GG
Q
F
QVVIG
NH
V
AD
-
VFL
A
VNSVA
G
LGE-
-
-
KAQQAPENDDKGNLLN---
--
RF
V
YVISG
IF
T
PLI
G
LM
A
AT
G
I
L
K
G
MLA
L
A
--------
L
T
FQWTTEQ-
S
G
T
----
Y
L
I
L
FSA
S
D
A
L
F
W
F
F
PI
I
L
GY
T
A
GKR
F
S
G
N
PFT
A
MV
I
G
GA
LV
---
HP
LILTAFEN
G
QKVDALG
L
DF
LGI
P
V
TLLN
Y
SSS
VIP
I
I
FSA
W
L
C
SI
L
E
RR
L
NAWL
P
SAIKNFFT
PL
LC
L
MV
ITP
I
T
F
LL
V
GP
L
S
T
WI
SEL
I
A
AGYLW
L
YQAV
-
PAFAG
AV
M
G
G
F
W
QIF
VM
F
G
L
H
WGLI
P
LI
I
NNF
--
TVL
G
YDT
M
I
PLL
MP
A
IM
AQ
fig|340197.3.peg.431
Escherichia coli F11 (12-336/624)
VGG
A
D
NI
V
S
LM
HC
A
TRLRF
K
L
K
D
ESKAQAEV
L
K
KTP
G
I
I
M
V
VE
S
GG
Q
F
QVVIG
NH
V
AD
-
VFL
A
VNSVA
G
LGE-
-
-
KAQQAPENDDKGNLLN---
--
RF
V
YVISG
IF
T
PLI
G
LM
A
AT
G
I
L
K
G
MLA
L
A
--------
L
T
FQWTTEQ-
S
G
T
----
Y
L
I
L
FSA
S
D
A
L
F
W
F
F
PI
I
L
GY
T
A
GKR
F
S
G
N
PFT
A
MV
I
G
GA
LV
---
HP
LILTAFEN
G
QKVDALG
L
DF
LGI
P
V
TLLN
Y
SSS
VIP
I
I
FSA
W
L
C
SI
L
E
RR
L
NAWL
P
SAIKNFFT
PL
LC
L
MV
ITP
I
T
F
LL
V
GP
L
S
T
WI
SEL
I
A
AGYLW
L
YQAV
-
PAFAG
AV
M
G
G
F
W
QIF
VM
F
G
L
H
WGLI
P
LI
I
NNF
--
TVL
G
YDT
M
I
PLL
MP
A
IM
AQ
fig|340197.5.peg.443
Escherichia coli F11 (12-336/624)
VGG
A
D
NI
V
S
LM
HC
A
TRLRF
K
L
K
D
ESKAQAEV
L
K
KTP
G
I
I
M
V
VE
S
GG
Q
F
QVVIG
NH
V
AD
-
VFL
A
VNSVA
G
LGE-
-
-
KAQQAPENDDKGNLLN---
--
RF
V
YVISG
IF
T
PLI
G
LM
A
AT
G
I
L
K
G
MLA
L
A
--------
L
T
FQWTTEQ-
S
G
T
----
Y
L
I
L
FSA
S
D
A
L
F
W
F
F
PI
I
L
GY
T
A
GKR
F
S
G
N
PFT
A
MV
I
G
GA
LV
---
HP
LILTAFEN
G
QKVDALG
L
DF
LGI
P
V
TLLN
Y
SSS
VIP
I
I
FSA
W
L
C
SI
L
E
RR
L
NAWL
P
SAIKNFFT
PL
LC
L
MV
ITP
I
T
F
LL
V
GP
L
S
T
WI
SEL
I
A
AGYLW
L
YQAV
-
PAFAG
AV
M
G
G
F
W
QIF
VM
F
G
L
H
WGLI
P
LI
I
NNF
--
TVL
G
YDT
M
I
PLL
MP
A
IM
AQ
fig|749546.3.peg.1502
Escherichia coli MS 185-1 (12-336/624)
VGG
A
D
NI
V
S
LM
HC
A
TRLRF
K
L
K
D
ESKAQAEV
L
K
KTP
G
I
I
M
V
VE
S
GG
Q
F
QVVIG
NH
V
AD
-
VFL
A
VNSVA
G
LGE-
-
-
KAQQAPENDDKGNLLN---
--
RF
V
YVISG
IF
T
PLI
G
LM
A
AT
G
I
L
K
G
MLA
L
A
--------
L
T
FQWTTEQ-
S
G
T
----
Y
L
I
L
FSA
S
D
A
L
F
W
F
F
PI
I
L
GY
T
A
GKR
F
S
G
N
PFT
A
MV
I
G
GA
LV
---
HP
LILTAFEN
G
QKVDALG
L
DF
LGI
P
V
TLLN
Y
SSS
VIP
I
I
FSA
W
L
C
SI
L
E
RR
L
NAWL
P
SAIKNFFT
PL
LC
L
MV
ITP
I
T
F
LL
V
GP
L
S
T
WI
SEL
I
A
AGYLW
L
YQAV
-
PAFAG
AV
M
G
G
F
W
QIF
VM
F
G
L
H
WGLI
P
LI
I
NNF
--
TVL
G
YDT
M
I
PLL
MP
A
IM
AQ
fig|749550.3.peg.2382
Escherichia coli MS 200-1 (12-336/624)
VGG
A
D
NI
V
S
LM
HC
A
TRLRF
K
L
K
D
ESKAQAEV
L
K
KTP
G
I
I
M
V
VE
S
GG
Q
F
QVVIG
NH
V
AD
-
VFL
A
VNSVA
G
LGE-
-
-
KAQQAPENDDKGNLLN---
--
RF
V
YVISG
IF
T
PLI
G
LM
A
AT
G
I
L
K
G
MLA
L
A
--------
L
T
FQWTTEQ-
S
G
T
----
Y
L
I
L
FSA
S
D
A
L
F
W
F
F
PI
I
L
GY
T
A
GKR
F
S
G
N
PFT
A
MV
I
G
GA
LV
---
HP
LILTAFEN
G
QKVDALG
L
DF
LGI
P
V
TLLN
Y
SSS
VIP
I
I
FSA
W
L
C
SI
L
E
RR
L
NAWL
P
SAIKNFFT
PL
LC
L
MV
ITP
I
T
F
LL
V
GP
L
S
T
WI
SEL
I
A
AGYLW
L
YQAV
-
PAFAG
AV
M
G
G
F
W
QIF
VM
F
G
L
H
WGLI
P
LI
I
NNF
--
TVL
G
YDT
M
I
PLL
MP
A
IM
AQ
fig|749528.3.peg.2843
Escherichia coli MS 45-1 (12-336/624)
VGG
A
D
NI
V
S
LM
HC
A
TRLRF
K
L
K
D
ESKAQAEV
L
K
KTP
G
I
I
M
V
VE
S
GG
Q
F
QVVIG
NH
V
AD
-
VFL
A
VNSVA
G
LGE-
-
-
KAQQAPENDDKGNLLN---
--
RF
V
YVISG
IF
T
PLI
G
LM
A
AT
G
I
L
K
G
MLA
L
A
--------
L
T
FQWTTEQ-
S
G
T
----
Y
L
I
L
FSA
S
D
A
L
F
W
F
F
PI
I
L
GY
T
A
GKR
F
S
G
N
PFT
A
MV
I
G
GA
LV
---
HP
LILTAFEN
G
QKVDALG
L
DF
LGI
P
V
TLLN
Y
SSS
VIP
I
I
FSA
W
L
C
SI
L
E
RR
L
NAWL
P
SAIKNFFT
PL
LC
L
MV
ITP
I
T
F
LL
V
GP
L
S
T
WI
SEL
I
A
AGYLW
L
YQAV
-
PAFAG
AV
M
G
G
F
W
QIF
VM
F
G
L
H
WGLI
P
LI
I
NNF
--
TVL
G
YDT
M
I
PLL
MP
A
IM
AQ
fig|199310.1.peg.4545
Escherichia coli CFT073 (37-361/649)
VGG
A
D
NI
V
S
LM
HC
A
TRLRF
K
L
K
D
ESKAQAEV
L
K
KTP
G
I
I
M
V
VE
S
GG
Q
F
QVVIG
NH
V
AD
-
VFL
A
VNSVA
G
LGE-
-
-
KAQQAPENDDKGNLLN---
--
RF
V
YVISG
IF
T
PLI
G
LM
A
AT
G
I
L
K
G
MLA
L
A
--------
L
T
FQWTTEQ-
S
G
T
----
Y
L
I
L
FSA
S
D
A
L
F
W
F
F
PI
I
L
GY
T
A
GKR
F
S
G
N
PFT
A
MV
I
G
GA
LV
---
HP
LILTAFEN
G
QKVDALG
L
DF
LGI
P
V
TLLN
Y
SSS
VIP
I
I
FSA
W
L
C
SI
L
E
RR
L
NAWL
P
SAIKNFFT
PL
LC
L
MV
ITP
I
T
F
LL
V
GP
L
S
T
WI
SEL
I
A
AGYLW
L
YQAV
-
PAFAG
AV
M
G
G
F
W
QIF
VM
F
G
L
H
WGLI
P
LI
I
NNF
--
TVL
G
YDT
M
I
PLL
MP
A
IM
AQ
fig|358709.5.peg.2286
Escherichia coli 101-1 (1-346/474)
MAKEISSELLN
T
I
L
TR
VGG
P
GNI
A
S
CG
N
C
M
TRLR
L
G
V
H
D
SSLVDPD-
IK
TLE
GV
K
GV
IL
T
SD
Q
V
QVV
F
G
PG
K
AH
R
AAK
A
MSELL
G
EAPV
Q
D
AAEIAAQNKRQLKAKQTSG
VQ
QF
L
AKFAT
IF
T
PLIP
GF
I
AA
GLLLG
IAT
LI
--------
A
T
VMHVPADA
Q
G
T
LPDA
L
N
F
M
KVF
S
K
G
L
F
T
FL
V
I
L
V
GY
N
A
AQA
FGGT
GVN
G
AI
IA
AL
FLLGY
N
P
AATTGYYA
G
FH-----
-
DF
FGL
PI
---D
P
RGN
I
I
G
V
L
IAA
W
A
C
AR
IE
GM
V
RRFM
P
DDLDMLLT
S
L
IT
LLI
TAT
LA
Y
L
I
I
M
P
L
G
G
W
L
FEG
M
S
WLFMH
L
NS--
-
NPFGC
AV
L
A
G
L
F
LIA
V
V
F
GVH
QGFI
P
VY
L
ALM
--
DSQ
G
FNS
L
F
P
I
L
SM
A
GA
G
Q
fig|413997.3.peg.2435
Escherichia coli B str. REL606 (1-346/474)
MAKEISSELLN
T
I
L
TR
VGG
P
GNI
A
S
CG
N
C
M
TRLR
L
G
V
H
D
SSLVDPD-
IK
TLE
GV
K
GV
IL
T
SD
Q
V
QVV
F
G
PG
K
AH
R
AAK
A
MSELL
G
EAPV
Q
D
AAEIAAQNKRQLKAKQTSG
VQ
QF
L
AKFAT
IF
T
PLIP
GF
I
AA
GLLLG
IAT
LI
--------
A
T
VMHVPADA
Q
G
T
LPDA
L
N
F
M
KVF
S
K
G
L
F
T
FL
V
I
L
V
GY
N
A
AQA
FGGT
GVN
G
AI
IA
AL
FLLGY
N
P
AATTGYYA
G
FH-----
-
DF
FGL
PI
---D
P
RGN
I
I
G
V
L
IAA
W
A
C
AR
IE
GM
V
RRFM
P
DDLDMLLT
S
L
IT
LLI
TAT
LA
Y
L
I
I
M
P
L
G
G
W
L
FEG
M
S
WLFMH
L
NS--
-
NPFGC
AV
L
A
G
L
F
LIA
V
V
F
GVH
QGFI
P
VY
L
ALM
--
DSQ
G
FNS
L
F
P
I
L
SM
A
GA
G
Q
fig|511693.5.peg.2448
Escherichia coli BL21 (1-346/474)
MAKEISSELLN
T
I
L
TR
VGG
P
GNI
A
S
CG
N
C
M
TRLR
L
G
V
H
D
SSLVDPD-
IK
TLE
GV
K
GV
IL
T
SD
Q
V
QVV
F
G
PG
K
AH
R
AAK
A
MSELL
G
EAPV
Q
D
AAEIAAQNKRQLKAKQTSG
VQ
QF
L
AKFAT
IF
T
PLIP
GF
I
AA
GLLLG
IAT
LI
--------
A
T
VMHVPADA
Q
G
T
LPDA
L
N
F
M
KVF
S
K
G
L
F
T
FL
V
I
L
V
GY
N
A
AQA
FGGT
GVN
G
AI
IA
AL
FLLGY
N
P
AATTGYYA
G
FH-----
-
DF
FGL
PI
---D
P
RGN
I
I
G
V
L
IAA
W
A
C
AR
IE
GM
V
RRFM
P
DDLDMLLT
S
L
IT
LLI
TAT
LA
Y
L
I
I
M
P
L
G
G
W
L
FEG
M
S
WLFMH
L
NS--
-
NPFGC
AV
L
A
G
L
F
LIA
V
V
F
GVH
QGFI
P
VY
L
ALM
--
DSQ
G
FNS
L
F
P
I
L
SM
A
GA
G
Q
fig|469008.4.peg.1288
Escherichia coli BL21(DE3) (1-346/474)
MAKEISSELLN
T
I
L
TR
VGG
P
GNI
A
S
CG
N
C
M
TRLR
L
G
V
H
D
SSLVDPD-
IK
TLE
GV
K
GV
IL
T
SD
Q
V
QVV
F
G
PG
K
AH
R
AAK
A
MSELL
G
EAPV
Q
D
AAEIAAQNKRQLKAKQTSG
VQ
QF
L
AKFAT
IF
T
PLIP
GF
I
AA
GLLLG
IAT
LI
--------
A
T
VMHVPADA
Q
G
T
LPDA
L
N
F
M
KVF
S
K
G
L
F
T
FL
V
I
L
V
GY
N
A
AQA
FGGT
GVN
G
AI
IA
AL
FLLGY
N
P
AATTGYYA
G
FH-----
-
DF
FGL
PI
---D
P
RGN
I
I
G
V
L
IAA
W
A
C
AR
IE
GM
V
RRFM
P
DDLDMLLT
S
L
IT
LLI
TAT
LA
Y
L
I
I
M
P
L
G
G
W
L
FEG
M
S
WLFMH
L
NS--
-
NPFGC
AV
L
A
G
L
F
LIA
V
V
F
GVH
QGFI
P
VY
L
ALM
--
DSQ
G
FNS
L
F
P
I
L
SM
A
GA
G
Q
fig|749547.3.peg.919
Escherichia coli MS 187-1 (1-346/474)
MAKEISSELLN
T
I
L
TR
VGG
P
GNI
A
S
CG
N
C
M
TRLR
L
G
V
H
D
SSLVDPD-
IK
TLE
GV
K
GV
IL
T
SD
Q
V
QVV
F
G
PG
K
AH
R
AAK
A
MSELL
G
EAPV
Q
D
AAEIAAQNKRQLKAKQTSG
VQ
QF
L
AKFAT
IF
T
PLIP
GF
I
AA
GLLLG
IAT
LI
--------
A
T
VMHVPADA
Q
G
T
LPDA
L
N
F
M
KVF
S
K
G
L
F
T
FL
V
I
L
V
GY
N
A
AQA
FGGT
GVN
G
AI
IA
AL
FLLGY
N
P
AATTGYYA
G
FH-----
-
DF
FGL
PI
---D
P
RGN
I
I
G
V
L
IAA
W
A
C
AR
IE
GM
V
RRFM
P
DDLDMLLT
S
L
IT
LLI
TAT
LA
Y
L
I
I
M
P
L
G
G
W
L
FEG
M
S
WLFMH
L
NS--
-
NPFGC
AV
L
A
G
L
F
LIA
V
V
F
GVH
QGFI
P
VY
L
ALM
--
DSQ
G
FNS
L
F
P
I
L
SM
A
GA
G
Q
fig|749532.3.peg.3185
Escherichia coli MS 78-1 (1-346/412)
MAKEISSELLN
T
I
L
TR
VGG
P
GNI
A
S
CG
N
C
M
TRLR
L
G
V
H
D
SSLVDPN-
IK
TLE
GV
K
GV
IL
T
SD
Q
V
QVV
F
G
PG
K
AH
R
AAK
A
MSELL
G
EAPV
Q
D
AAEIAAQNKRQLKAKQTSG
VQ
QF
L
AKFAT
IF
T
PLIP
GF
I
AA
GLLLG
IAT
LI
--------
A
T
VMHVPADA
Q
G
T
LPDA
L
N
F
M
KVF
S
K
G
L
F
T
FL
V
I
L
V
GY
N
A
AQA
FGGT
GVN
G
AI
IA
AL
FLLGY
N
P
AATTGYYA
G
FH-----
-
DF
FGL
PI
---D
P
RGN
I
I
G
V
L
IAA
W
A
C
AR
IE
GM
V
RRFM
P
DDLDMLLT
S
L
IT
LLI
TAT
LA
Y
L
I
I
M
P
L
G
G
W
L
FEG
M
S
WLFMH
L
NS--
-
NPFGC
AV
L
A
G
L
F
LIA
V
V
F
GVH
QGFI
P
VY
L
ALM
--
DSQ
G
FNS
L
F
P
I
L
SM
A
GA
G
Q
fig|344601.3.peg.2165
Escherichia coli B171 (12-325/485)
V
I
AA
L
GG
V
D
NI
S
A
VT
HC
M
TRLRF
V
I
K
D
DQLIDSPT
L
K
TIP
GV
L
GV
VR
S
DN
Q
C
QV
I
IG
NT
V
SQ
-
---
A
FQEVV
S
LLPG
-
D
MQPAQPVGKPKLTLRRIGA
--
GI
L
DALIS
TM
S
PLIP
AI
I
GG
S
MV
K
-
LLA
M
I
--------
L
E
MSGVLTKG
S
P
T
----
L
T
I
L
NVI
GDG
A
F
F
FLP
L
M
V
AA
SA
AIK
F
KTN
MSL
A
IA
IA
GV
LV
---
HP
SFIELMAK
A
AQGEHV-
-
E
F
ALI
P
V
TAVK
Y
TYT
VIP
A
L
VMT
W
C
L
SY
IE
RW
V
DRIT
P
AVTKNFLK
P
M
LI
V
LI
AAP
LA
I
LLIGP
I
G
I
WI
GSA
IS
ALVYT
I
HGYL
-
GWLSV
A
I
M
G
A
LW
PLL
VMTG
M
H
RVFT
P
TI
I
QTI
--
AET
G
fig|344601.5.peg.2260
Escherichia coli B171 (12-325/485)
V
I
AA
L
GG
V
D
NI
S
A
VT
HC
M
TRLRF
V
I
K
D
DQLIDSPT
L
K
TIP
GV
L
GV
VR
S
DN
Q
C
QV
I
IG
NT
V
SQ
-
---
A
FQEVV
S
LLPG
-
D
MQPAQPVGKPKLTLRRIGA
--
GI
L
DALIS
TM
S
PLIP
AI
I
GG
S
MV
K
-
LLA
M
I
--------
L
E
MSGVLTKG
S
P
T
----
L
T
I
L
NVI
GDG
A
F
F
FLP
L
M
V
AA
SA
AIK
F
KTN
MSL
A
IA
IA
GV
LV
---
HP
SFIELMAK
A
AQGEHV-
-
E
F
ALI
P
V
TAVK
Y
TYT
VIP
A
L
VMT
W
C
L
SY
IE
RW
V
DRIT
P
AVTKNFLK
P
M
LI
V
LI
AAP
LA
I
LLIGP
I
G
I
WI
GSA
IS
ALVYT
I
HGYL
-
GWLSV
A
I
M
G
A
LW
PLL
VMTG
M
H
RVFT
P
TI
I
QTI
--
AET
G
fig|340185.3.peg.3387
Escherichia coli E22 (12-325/485)
V
I
AA
L
GG
V
D
NI
S
A
VT
HC
M
TRLRF
V
I
K
D
DQLIDSPT
L
K
TIP
GV
L
GV
VR
S
DN
Q
C
QV
I
IG
NT
V
SQ
-
---
A
FQEVV
S
LLPG
-
D
MQPAQPVGKPKLTLRRIGA
--
GI
L
DALIS
TM
S
PLIP
AI
I
GG
S
MV
K
-
LLA
M
I
--------
L
E
MSGVLTKG
S
P
T
----
L
T
I
L
NVI
GDG
A
F
F
FLP
L
M
V
AA
SA
AIK
F
KTN
MSL
A
IA
IA
GV
LV
---
HP
SFIELMAK
A
AQGEHV-
-
E
F
ALI
P
V
TAVK
Y
TYT
VIP
A
L
VMT
W
C
L
SY
IE
RW
V
DRIT
P
AVTKNFLK
P
M
LI
V
LI
AAP
LA
I
LLIGP
I
G
I
WI
GSA
IS
ALVYT
I
HGYL
-
GWLSV
A
I
M
G
A
LW
PLL
VMTG
M
H
RVFT
P
TI
I
QTI
--
AET
G
fig|340185.4.peg.3563
Escherichia coli E22 (12-325/485)
V
I
AA
L
GG
V
D
NI
S
A
VT
HC
M
TRLRF
V
I
K
D
DQLIDSPT
L
K
TIP
GV
L
GV
VR
S
DN
Q
C
QV
I
IG
NT
V
SQ
-
---
A
FQEVV
S
LLPG
-
D
MQPAQPVGKPKLTLRRIGA
--
GI
L
DALIS
TM
S
PLIP
AI
I
GG
S
MV
K
-
LLA
M
I
--------
L
E
MSGVLTKG
S
P
T
----
L
T
I
L
NVI
GDG
A
F
F
FLP
L
M
V
AA
SA
AIK
F
KTN
MSL
A
IA
IA
GV
LV
---
HP
SFIELMAK
A
AQGEHV-
-
E
F
ALI
P
V
TAVK
Y
TYT
VIP
A
L
VMT
W
C
L
SY
IE
RW
V
DRIT
P
AVTKNFLK
P
M
LI
V
LI
AAP
LA
I
LLIGP
I
G
I
WI
GSA
IS
ALVYT
I
HGYL
-
GWLSV
A
I
M
G
A
LW
PLL
VMTG
M
H
RVFT
P
TI
I
QTI
--
AET
G
fig|405955.13.peg.4177
Escherichia coli APEC O1 (12-336/624)
VGG
A
D
NI
V
S
LM
HC
A
TRLRF
K
L
K
D
ESKAQAEV
L
K
KTP
G
I
I
M
V
VE
S
GG
Q
F
QVVIG
NH
V
AD
-
VFL
A
VNSVA
G
LGE-
-
-
KAQQAPENDDKDNLLN---
--
RF
F
YVISG
IF
T
PLI
G
LM
A
AT
G
I
L
K
G
MLA
L
A
--------
L
T
FQWATEQ-
S
G
T
----
Y
L
I
L
FSA
S
D
A
L
F
W
F
F
PI
I
L
GY
T
A
GKR
F
S
G
N
PFT
A
MV
I
G
GA
LV
---
HP
LILTAFEN
G
QKVDALG
L
DF
LGI
P
V
TLLN
Y
SSS
VIP
I
I
FSA
W
L
C
SI
L
E
RR
L
NTWL
P
SAIKNFFT
PL
LC
L
MV
ITP
I
T
F
LL
V
GP
L
S
T
WI
SEL
I
A
AGYLW
L
YQAV
-
PAFAG
AV
M
G
G
F
W
QIF
VM
F
G
L
H
WGLI
P
LI
I
NNF
--
TVL
G
YDT
M
I
PLL
MP
A
IM
AQ
fig|405955.9.peg.3495
Escherichia coli APEC O1 (37-361/649)
VGG
A
D
NI
V
S
LM
HC
A
TRLRF
K
L
K
D
ESKAQAEV
L
K
KTP
G
I
I
M
V
VE
S
GG
Q
F
QVVIG
NH
V
AD
-
VFL
A
VNSVA
G
LGE-
-
-
KAQQAPENDDKDNLLN---
--
RF
F
YVISG
IF
T
PLI
G
LM
A
AT
G
I
L
K
G
MLA
L
A
--------
L
T
FQWATEQ-
S
G
T
----
Y
L
I
L
FSA
S
D
A
L
F
W
F
F
PI
I
L
GY
T
A
GKR
F
S
G
N
PFT
A
MV
I
G
GA
LV
---
HP
LILTAFEN
G
QKVDALG
L
DF
LGI
P
V
TLLN
Y
SSS
VIP
I
I
FSA
W
L
C
SI
L
E
RR
L
NTWL
P
SAIKNFFT
PL
LC
L
MV
ITP
I
T
F
LL
V
GP
L
S
T
WI
SEL
I
A
AGYLW
L
YQAV
-
PAFAG
AV
M
G
G
F
W
QIF
VM
F
G
L
H
WGLI
P
LI
I
NNF
--
TVL
G
YDT
M
I
PLL
MP
A
IM
AQ
fig|714962.3.peg.4213
Escherichia coli IHE3034 (12-336/624)
VGG
A
D
NI
V
S
LM
HC
A
TRLRF
K
L
K
D
ESKAQAEV
L
K
KTP
G
I
I
M
V
VE
S
GG
Q
F
QVVIG
NH
V
AD
-
VFL
A
VNSVA
G
LGE-
-
-
KAQQAPENDDKDNLLN---
--
RF
F
YVISG
IF
T
PLI
G
LM
A
AT
G
I
L
K
G
MLA
L
A
--------
L
T
FQWATEQ-
S
G
T
----
Y
L
I
L
FSA
S
D
A
L
F
W
F
F
PI
I
L
GY
T
A
GKR
F
S
G
N
PFT
A
MV
I
G
GA
LV
---
HP
LILTAFEN
G
QKVDALG
L
DF
LGI
P
V
TLLN
Y
SSS
VIP
I
I
FSA
W
L
C
SI
L
E
RR
L
NTWL
P
SAIKNFFT
PL
LC
L
MV
ITP
I
T
F
LL
V
GP
L
S
T
WI
SEL
I
A
AGYLW
L
YQAV
-
PAFAG
AV
M
G
G
F
W
QIF
VM
F
G
L
H
WGLI
P
LI
I
NNF
--
TVL
G
YDT
M
I
PLL
MP
A
IM
AQ
fig|585035.6.peg.4074
Escherichia coli S88 (12-336/624)
VGG
A
D
NI
V
S
LM
HC
A
TRLRF
K
L
K
D
ESKAQAEV
L
K
KTP
G
I
I
M
V
VE
S
GG
Q
F
QVVIG
NH
V
AD
-
VFL
A
VNSVA
G
LGE-
-
-
KAQQAPENDDKDNLLN---
--
RF
F
YVISG
IF
T
PLI
G
LM
A
AT
G
I
L
K
G
MLA
L
A
--------
L
T
FQWATEQ-
S
G
T
----
Y
L
I
L
FSA
S
D
A
L
F
W
F
F
PI
I
L
GY
T
A
GKR
F
S
G
N
PFT
A
MV
I
G
GA
LV
---
HP
LILTAFEN
G
QKVDALG
L
DF
LGI
P
V
TLLN
Y
SSS
VIP
I
I
FSA
W
L
C
SI
L
E
RR
L
NTWL
P
SAIKNFFT
PL
LC
L
MV
ITP
I
T
F
LL
V
GP
L
S
T
WI
SEL
I
A
AGYLW
L
YQAV
-
PAFAG
AV
M
G
G
F
W
QIF
VM
F
G
L
H
WGLI
P
LI
I
NNF
--
TVL
G
YDT
M
I
PLL
MP
A
IM
AQ
fig|869729.3.peg.4032
Escherichia coli UM146 (12-336/624)
VGG
A
D
NI
V
S
LM
HC
A
TRLRF
K
L
K
D
ESKAQAEV
L
K
KTP
G
I
I
M
V
VE
S
GG
Q
F
QVVIG
NH
V
AD
-
VFL
A
VNSVA
G
LGE-
-
-
KAQQAPENDDKDNLLN---
--
RF
F
YVISG
IF
T
PLI
G
LM
A
AT
G
I
L
K
G
MLA
L
A
--------
L
T
FQWATEQ-
S
G
T
----
Y
L
I
L
FSA
S
D
A
L
F
W
F
F
PI
I
L
GY
T
A
GKR
F
S
G
N
PFT
A
MV
I
G
GA
LV
---
HP
LILTAFEN
G
QKVDALG
L
DF
LGI
P
V
TLLN
Y
SSS
VIP
I
I
FSA
W
L
C
SI
L
E
RR
L
NTWL
P
SAIKNFFT
PL
LC
L
MV
ITP
I
T
F
LL
V
GP
L
S
T
WI
SEL
I
A
AGYLW
L
YQAV
-
PAFAG
AV
M
G
G
F
W
QIF
VM
F
G
L
H
WGLI
P
LI
I
NNF
--
TVL
G
YDT
M
I
PLL
MP
A
IM
AQ
fig|364106.7.peg.4180
Escherichia coli UTI89 (12-336/624)
VGG
A
D
NI
V
S
LM
HC
A
TRLRF
K
L
K
D
ESKAQAEV
L
K
KTP
G
I
I
M
V
VE
S
GG
Q
F
QVVIG
NH
V
AD
-
VFL
A
VNSVA
G
LGE-
-
-
KAQQAPENDDKDNLLN---
--
RF
F
YVISG
IF
T
PLI
G
LM
A
AT
G
I
L
K
G
MLA
L
A
--------
L
T
FQWATEQ-
S
G
T
----
Y
L
I
L
FSA
S
D
A
L
F
W
F
F
PI
I
L
GY
T
A
GKR
F
S
G
N
PFT
A
MV
I
G
GA
LV
---
HP
LILTAFEN
G
QKVDALG
L
DF
LGI
P
V
TLLN
Y
SSS
VIP
I
I
FSA
W
L
C
SI
L
E
RR
L
NTWL
P
SAIKNFFT
PL
LC
L
MV
ITP
I
T
F
LL
V
GP
L
S
T
WI
SEL
I
A
AGYLW
L
YQAV
-
PAFAG
AV
M
G
G
F
W
QIF
VM
F
G
L
H
WGLI
P
LI
I
NNF
--
TVL
G
YDT
M
I
PLL
MP
A
IM
AQ
fig|364106.8.peg.4182
Escherichia coli UTI89 (12-336/624)
VGG
A
D
NI
V
S
LM
HC
A
TRLRF
K
L
K
D
ESKAQAEV
L
K
KTP
G
I
I
M
V
VE
S
GG
Q
F
QVVIG
NH
V
AD
-
VFL
A
VNSVA
G
LGE-
-
-
KAQQAPENDDKDNLLN---
--
RF
F
YVISG
IF
T
PLI
G
LM
A
AT
G
I
L
K
G
MLA
L
A
--------
L
T
FQWATEQ-
S
G
T
----
Y
L
I
L
FSA
S
D
A
L
F
W
F
F
PI
I
L
GY
T
A
GKR
F
S
G
N
PFT
A
MV
I
G
GA
LV
---
HP
LILTAFEN
G
QKVDALG
L
DF
LGI
P
V
TLLN
Y
SSS
VIP
I
I
FSA
W
L
C
SI
L
E
RR
L
NTWL
P
SAIKNFFT
PL
LC
L
MV
ITP
I
T
F
LL
V
GP
L
S
T
WI
SEL
I
A
AGYLW
L
YQAV
-
PAFAG
AV
M
G
G
F
W
QIF
VM
F
G
L
H
WGLI
P
LI
I
NNF
--
TVL
G
YDT
M
I
PLL
MP
A
IM
AQ
fig|550672.3.peg.2916
Escherichia coli B088 (12-325/485)
V
I
AA
L
GG
V
D
NI
S
A
VT
HC
M
TRLRF
V
I
K
D
DQLIDSPT
L
K
TIP
GV
L
GV
VR
S
DN
Q
C
QV
I
IG
NT
V
SQ
-
---
A
FQEVV
S
LLPG
-
D
MQPAQPVGKPKLTLRRIGA
--
GI
L
DALIS
TM
S
PLIP
AI
I
GG
S
MV
K
-
LLA
M
I
--------
L
E
MSGVLTKG
S
P
T
----
L
T
I
L
NVI
GDG
A
F
F
FLP
L
M
V
AA
SA
AIK
F
KTN
MSL
A
IA
IA
GV
LV
---
HP
SFIELMAK
A
AQGEHV-
-
E
F
ALI
P
V
TAVK
Y
TYT
VIP
A
L
VMT
W
C
L
SY
IE
RW
V
DRIT
P
AVTKNFLK
P
M
LI
V
LI
AAP
LA
I
LLIGP
I
G
I
WI
GSA
IS
ALVYT
I
HGYL
-
GWLSV
A
I
M
G
A
LW
PLL
VMTG
M
H
RVFT
P
TI
I
QTI
--
AET
G
fig|340186.3.peg.2874
Escherichia coli E110019 (12-325/485)
V
I
AA
L
GG
V
D
NI
S
A
VT
HC
M
TRLRF
V
I
K
D
DQLIDSPT
L
K
TIP
GV
L
GV
VR
S
DN
Q
C
QV
I
IG
NT
V
SQ
-
---
A
FQEVV
S
LLPG
-
D
MQPAQPVGKPKLTLRRIGA
--
GI
L
DALIS
TM
S
PLIP
AI
I
GG
S
MV
K
-
LLA
M
I
--------
L
E
MSGVLTKG
S
P
T
----
L
T
I
L
NVI
GDG
A
F
F
FLP
L
M
V
AA
SA
AIK
F
KTN
MSL
A
IA
IA
GV
LV
---
HP
SFIELMAK
A
AQGEHV-
-
E
F
ALI
P
V
TAVK
Y
TYT
VIP
A
L
VMT
W
C
L
SY
IE
RW
V
DRIT
P
AVTKNFLK
P
M
LI
V
LI
AAP
LA
I
LLIGP
I
G
I
WI
GSA
IS
ALVYT
I
HGYL
-
GWLSV
A
I
M
G
A
LW
PLL
VMTG
M
H
RVFT
P
TI
I
QTI
--
AET
G
fig|340186.5.peg.2988
Escherichia coli E110019 (12-325/485)
V
I
AA
L
GG
V
D
NI
S
A
VT
HC
M
TRLRF
V
I
K
D
DQLIDSPT
L
K
TIP
GV
L
GV
VR
S
DN
Q
C
QV
I
IG
NT
V
SQ
-
---
A
FQEVV
S
LLPG
-
D
MQPAQPVGKPKLTLRRIGA
--
GI
L
DALIS
TM
S
PLIP
AI
I
GG
S
MV
K
-
LLA
M
I
--------
L
E
MSGVLTKG
S
P
T
----
L
T
I
L
NVI
GDG
A
F
F
FLP
L
M
V
AA
SA
AIK
F
KTN
MSL
A
IA
IA
GV
LV
---
HP
SFIELMAK
A
AQGEHV-
-
E
F
ALI
P
V
TAVK
Y
TYT
VIP
A
L
VMT
W
C
L
SY
IE
RW
V
DRIT
P
AVTKNFLK
P
M
LI
V
LI
AAP
LA
I
LLIGP
I
G
I
WI
GSA
IS
ALVYT
I
HGYL
-
GWLSV
A
I
M
G
A
LW
PLL
VMTG
M
H
RVFT
P
TI
I
QTI
--
AET
G
fig|585397.7.peg.4407
Escherichia coli ED1a (12-336/624)
VGG
A
D
NI
V
S
LM
HC
A
TRLRF
K
L
K
D
ESKAQAEV
L
K
KTP
G
I
I
M
V
VE
S
GG
Q
F
QVVIG
NH
V
AD
-
VFL
A
VNSVA
G
LGE-
-
-
KAQQAPENDDKGNLLN---
--
RF
V
YVISG
IF
T
PLI
G
LM
A
AT
G
I
L
K
G
MLA
L
A
--------
L
T
FQWTTEQ-
S
G
T
----
Y
L
I
L
FSA
S
D
A
L
F
W
F
F
PI
I
L
GY
T
A
GKR
F
S
G
N
PFT
A
MV
I
G
GA
LV
---
HP
LILTAFEN
G
QKVDALG
L
DF
LGI
P
V
TLLN
Y
SSS
VIP
I
I
FSA
W
L
C
SI
L
E
RR
L
NAWL
P
SAIKNFFT
PL
LC
L
MV
ITP
I
T
F
LL
V
GP
L
S
T
WI
SEL
I
A
AGYLW
L
YQAV
-
PAFAG
AV
M
G
G
F
W
QIF
VM
F
G
L
H
WGLI
P
LI
I
NNF
--
TVL
G
YDT
M
I
PLL
RP
A
IM
AQ
fig|585397.9.peg.4404
Escherichia coli ED1a (12-336/624)
VGG
A
D
NI
V
S
LM
HC
A
TRLRF
K
L
K
D
ESKAQAEV
L
K
KTP
G
I
I
M
V
VE
S
GG
Q
F
QVVIG
NH
V
AD
-
VFL
A
VNSVA
G
LGE-
-
-
KAQQAPENDDKGNLLN---
--
RF
V
YVISG
IF
T
PLI
G
LM
A
AT
G
I
L
K
G
MLA
L
A
--------
L
T
FQWTTEQ-
S
G
T
----
Y
L
I
L
FSA
S
D
A
L
F
W
F
F
PI
I
L
GY
T
A
GKR
F
S
G
N
PFT
A
MV
I
G
GA
LV
---
HP
LILTAFEN
G
QKVDALG
L
DF
LGI
P
V
TLLN
Y
SSS
VIP
I
I
FSA
W
L
C
SI
L
E
RR
L
NAWL
P
SAIKNFFT
PL
LC
L
MV
ITP
I
T
F
LL
V
GP
L
S
T
WI
SEL
I
A
AGYLW
L
YQAV
-
PAFAG
AV
M
G
G
F
W
QIF
VM
F
G
L
H
WGLI
P
LI
I
NNF
--
TVL
G
YDT
M
I
PLL
RP
A
IM
AQ
fig|749538.3.peg.4795
Escherichia coli MS 116-1 (1-346/474)
MAKEISSELLN
T
I
L
TR
VGG
P
GNI
A
S
CG
N
C
M
TRLR
L
G
V
H
D
SSLVDPN-
IK
TLE
GV
K
GV
IL
T
SD
Q
V
QVV
F
G
PG
K
AH
R
AAK
A
MSELL
G
EAPV
Q
D
AAEIAAQNKRQLKAKQTSG
VQ
QF
L
AKFAT
IF
T
PLIP
GF
I
AA
GLLLG
IAT
LI
--------
A
T
VMHVPADA
Q
G
T
LPDA
L
N
F
M
KVF
S
K
G
L
F
T
FL
V
I
L
V
GY
N
A
AQA
FGGT
GVN
G
AI
IA
AL
FLLGY
N
P
AATTGYYA
G
FH-----
-
DF
FGL
PI
---D
P
RGN
I
I
G
V
L
IAA
W
A
C
AR
IE
GM
V
RRFM
P
DDLDMLLT
S
L
IT
LLI
TAT
LA
Y
L
I
I
M
P
L
G
G
W
L
FEG
M
S
WLFMH
L
NS--
-
NPFGC
AV
L
A
G
L
F
LIA
V
V
F
GVH
QGFI
P
VY
L
ALM
--
DSQ
G
FNS
L
F
P
I
L
SM
A
GA
G
Q
fig|749544.3.peg.2880
Escherichia coli MS 175-1 (1-346/474)
MAKEISSELLN
T
I
L
TR
VGG
P
GNI
A
S
CG
N
C
M
TRLR
L
G
V
H
D
SSLVDPN-
IK
TLE
GV
K
GV
IL
T
SD
Q
V
QVV
F
G
PG
K
AH
R
AAK
A
MSELL
G
EAPV
Q
D
AAEIAAQNKRQLKAKQTSG
VQ
QF
L
AKFAT
IF
T
PLIP
GF
I
AA
GLLLG
IAT
LI
--------
A
T
VMHVPADA
Q
G
T
LPDA
L
N
F
M
KVF
S
K
G
L
F
T
FL
V
I
L
V
GY
N
A
AQA
FGGT
GVN
G
AI
IA
AL
FLLGY
N
P
AATTGYYA
G
FH-----
-
DF
FGL
PI
---D
P
RGN
I
I
G
V
L
IAA
W
A
C
AR
IE
GM
V
RRFM
P
DDLDMLLT
S
L
IT
LLI
TAT
LA
Y
L
I
I
M
P
L
G
G
W
L
FEG
M
S
WLFMH
L
NS--
-
NPFGC
AV
L
A
G
L
F
LIA
V
V
F
GVH
QGFI
P
VY
L
ALM
--
DSQ
G
FNS
L
F
P
I
L
SM
A
GA
G
Q
fig|331112.3.peg.3689
Escherichia coli HS (7-336/625)
K
I
V
AG
VGG
A
D
NI
V
S
LM
HC
A
TRLRF
K
L
K
D
ESKAQAEV
L
K
KTP
G
I
I
M
V
VE
S
GG
Q
F
QVVIG
NH
V
AD
-
VFL
A
VNSVA
G
LDE-
-
-
KAQQAPENDDKGNLLN---
--
RF
V
YVISG
IF
T
PLI
G
LM
A
AT
G
I
L
K
G
MLA
L
A
--------
L
T
FQWTTEQ-
S
G
T
----
Y
L
I
L
FSA
S
D
A
L
F
W
F
F
PI
I
L
GY
T
A
GKR
FGG
N
PFT
A
MV
I
G
GA
LV
---
HP
LILTAFEN
G
QKADALG
L
DF
LGI
P
V
TLLN
Y
SSS
VIP
I
I
FSA
W
L
C
SI
L
E
RR
L
NAWL
P
SAIKNFFT
PL
LC
L
MV
IRP
VT
F
LL
V
GP
L
S
T
WI
SEL
I
A
AGYLW
L
YQAV
-
PAFAG
AV
M
G
G
F
W
QIF
VM
F
G
L
H
WGLV
P
LC
I
NNF
--
TVL
G
YDT
M
I
PLL
MP
A
IM
AQ
fig|331112.6.peg.3845
Escherichia coli HS (7-336/625)
K
I
V
AG
VGG
A
D
NI
V
S
LM
HC
A
TRLRF
K
L
K
D
ESKAQAEV
L
K
KTP
G
I
I
M
V
VE
S
GG
Q
F
QVVIG
NH
V
AD
-
VFL
A
VNSVA
G
LDE-
-
-
KAQQAPENDDKGNLLN---
--
RF
V
YVISG
IF
T
PLI
G
LM
A
AT
G
I
L
K
G
MLA
L
A
--------
L
T
FQWTTEQ-
S
G
T
----
Y
L
I
L
FSA
S
D
A
L
F
W
F
F
PI
I
L
GY
T
A
GKR
FGG
N
PFT
A
MV
I
G
GA
LV
---
HP
LILTAFEN
G
QKADALG
L
DF
LGI
P
V
TLLN
Y
SSS
VIP
I
I
FSA
W
L
C
SI
L
E
RR
L
NAWL
P
SAIKNFFT
PL
LC
L
MV
IRP
VT
F
LL
V
GP
L
S
T
WI
SEL
I
A
AGYLW
L
YQAV
-
PAFAG
AV
M
G
G
F
W
QIF
VM
F
G
L
H
WGLV
P
LC
I
NNF
--
TVL
G
YDT
M
I
PLL
MP
A
IM
AQ
fig|439855.10.peg.2742
Escherichia coli SMS-3-5 (1-346/474)
MAKEISSELLN
T
I
L
TR
VGG
P
GNI
A
S
CG
N
C
M
TRLR
L
G
V
H
D
SSLVDPN-
IK
TLE
GV
K
GV
IL
T
SD
Q
V
QVV
F
G
PG
K
AH
R
AAK
A
MSELL
G
EAPI
Q
D
AAEIAAQNKRQLKAKQTSG
VQ
QF
L
AKFAT
IF
T
PLIP
GF
I
AA
GLLLG
IAT
LI
--------
A
T
VMHVPADA
Q
G
T
LPDA
L
N
F
M
KVF
S
K
G
L
F
T
FL
V
I
L
V
GY
N
A
AQA
FGGT
GVN
G
AI
IA
AL
FLLGY
N
P
AATTGYYA
G
FH-----
-
DF
FGL
PI
---D
P
RGN
I
I
G
V
L
IAA
W
A
C
AR
IE
GM
V
RRFM
P
DDLDMLLT
S
L
IT
LLI
TAT
LA
Y
L
I
I
M
P
L
G
G
W
L
FEG
M
S
WLFMH
L
NS--
-
NPLGC
AV
L
A
G
L
F
LIA
V
V
F
GVH
QGFI
P
VY
L
ALM
--
DSQ
G
FNS
L
F
P
I
L
SM
A
GA
G
Q
fig|670888.3.peg.3862
Escherichia coli 1827-70 (1-346/474)
MAKEISSELLN
T
I
L
TR
VGG
P
GNI
A
S
CG
N
C
M
TRLR
L
G
V
H
D
SSLVDPN-
IK
TLE
GV
K
GV
IL
T
SD
Q
V
QVV
F
G
PG
K
AH
R
AAK
A
MSELL
G
EAPV
Q
D
AAEIAAQNKRQLKAKQTSG
VQ
QF
L
AKFAT
IF
T
PLIP
GF
I
AA
GLLLG
IAT
LI
--------
A
T
VMHVPADA
Q
G
T
LPDA
L
N
F
M
KVF
S
K
G
L
F
T
FL
V
I
L
V
GY
N
A
AQA
FGGT
GVN
G
AI
IA
AL
FLLGY
N
P
AATTGYYA
G
FH-----
-
DF
FGL
PI
---D
P
RGN
I
I
G
V
L
IAA
W
A
C
AR
IE
GM
V
RRFM
P
DDLDMLLT
S
L
IT
LLI
TAT
LA
Y
L
I
I
M
P
L
G
G
W
L
FEG
M
S
WLFMH
L
NS--
-
NPFGC
AV
L
A
G
L
F
LIA
V
V
F
GVH
QGFI
P
VY
L
ALM
--
DSQ
G
FNS
L
F
P
I
L
SM
A
GA
G
Q
fig|344610.3.peg.379
Escherichia coli 53638 (1-346/474)
MAKEISSELLN
T
I
L
TR
VGG
P
GNI
A
S
CG
N
C
M
TRLR
L
G
V
H
D
SSLVDPN-
IK
TLE
GV
K
GV
IL
T
SD
Q
V
QVV
F
G
PG
K
AH
R
AAK
A
MSELL
G
EAPV
Q
D
AAEIAAQNKRQLKAKQTSG
VQ
QF
L
AKFAT
IF
T
PLIP
GF
I
AA
GLLLG
IAT
LI
--------
A
T
VMHVPADA
Q
G
T
LPDA
L
N
F
M
KVF
S
K
G
L
F
T
FL
V
I
L
V
GY
N
A
AQA
FGGT
GVN
G
AI
IA
AL
FLLGY
N
P
AATTGYYA
G
FH-----
-
DF
FGL
PI
---D
P
RGN
I
I
G
V
L
IAA
W
A
C
AR
IE
GM
V
RRFM
P
DDLDMLLT
S
L
IT
LLI
TAT
LA
Y
L
I
I
M
P
L
G
G
W
L
FEG
M
S
WLFMH
L
NS--
-
NPFGC
AV
L
A
G
L
F
LIA
V
V
F
GVH
QGFI
P
VY
L
ALM
--
DSQ
G
FNS
L
F
P
I
L
SM
A
GA
G
Q
fig|344610.7.peg.3903
Escherichia coli 53638 (1-346/474)
MAKEISSELLN
T
I
L
TR
VGG
P
GNI
A
S
CG
N
C
M
TRLR
L
G
V
H
D
SSLVDPN-
IK
TLE
GV
K
GV
IL
T
SD
Q
V
QVV
F
G
PG
K
AH
R
AAK
A
MSELL
G
EAPV
Q
D
AAEIAAQNKRQLKAKQTSG
VQ
QF
L
AKFAT
IF
T
PLIP
GF
I
AA
GLLLG
IAT
LI
--------
A
T
VMHVPADA
Q
G
T
LPDA
L
N
F
M
KVF
S
K
G
L
F
T
FL
V
I
L
V
GY
N
A
AQA
FGGT
GVN
G
AI
IA
AL
FLLGY
N
P
AATTGYYA
G
FH-----
-
DF
FGL
PI
---D
P
RGN
I
I
G
V
L
IAA
W
A
C
AR
IE
GM
V
RRFM
P
DDLDMLLT
S
L
IT
LLI
TAT
LA
Y
L
I
I
M
P
L
G
G
W
L
FEG
M
S
WLFMH
L
NS--
-
NPFGC
AV
L
A
G
L
F
LIA
V
V
F
GVH
QGFI
P
VY
L
ALM
--
DSQ
G
FNS
L
F
P
I
L
SM
A
GA
G
Q
fig|481805.3.peg.1338
Escherichia coli ATCC 8739 (1-346/474)
MAKEISSELLN
T
I
L
TR
VGG
P
GNI
A
S
CG
N
C
M
TRLR
L
G
V
H
D
SSLVDPN-
IK
TLE
GV
K
GV
IL
T
SD
Q
V
QVV
F
G
PG
K
AH
R
AAK
A
MSELL
G
EAPV
Q
D
AAEIAAQNKRQLKAKQTSG
VQ
QF
L
AKFAT
IF
T
PLIP
GF
I
AA
GLLLG
IAT
LI
--------
A
T
VMHVPADA
Q
G
T
LPDA
L
N
F
M
KVF
S
K
G
L
F
T
FL
V
I
L
V
GY
N
A
AQA
FGGT
GVN
G
AI
IA
AL
FLLGY
N
P
AATTGYYA
G
FH-----
-
DF
FGL
PI
---D
P
RGN
I
I
G
V
L
IAA
W
A
C
AR
IE
GM
V
RRFM
P
DDLDMLLT
S
L
IT
LLI
TAT
LA
Y
L
I
I
M
P
L
G
G
W
L
FEG
M
S
WLFMH
L
NS--
-
NPFGC
AV
L
A
G
L
F
LIA
V
V
F
GVH
QGFI
P
VY
L
ALM
--
DSQ
G
FNS
L
F
P
I
L
SM
A
GA
G
Q
fig|481805.6.peg.1339
Escherichia coli ATCC 8739 (1-346/474)
MAKEISSELLN
T
I
L
TR
VGG
P
GNI
A
S
CG
N
C
M
TRLR
L
G
V
H
D
SSLVDPN-
IK
TLE
GV
K
GV
IL
T
SD
Q
V
QVV
F
G
PG
K
AH
R
AAK
A
MSELL
G
EAPV
Q
D
AAEIAAQNKRQLKAKQTSG
VQ
QF
L
AKFAT
IF
T
PLIP
GF
I
AA
GLLLG
IAT
LI
--------
A
T
VMHVPADA
Q
G
T
LPDA
L
N
F
M
KVF
S
K
G
L
F
T
FL
V
I
L
V
GY
N
A
AQA
FGGT
GVN
G
AI
IA
AL
FLLGY
N
P
AATTGYYA
G
FH-----
-
DF
FGL
PI
---D
P
RGN
I
I
G
V
L
IAA
W
A
C
AR
IE
GM
V
RRFM
P
DDLDMLLT
S
L
IT
LLI
TAT
LA
Y
L
I
I
M
P
L
G
G
W
L
FEG
M
S
WLFMH
L
NS--
-
NPFGC
AV
L
A
G
L
F
LIA
V
V
F
GVH
QGFI
P
VY
L
ALM
--
DSQ
G
FNS
L
F
P
I
L
SM
A
GA
G
Q
fig|344601.3.peg.1542
Escherichia coli B171 (1-346/474)
MAKEISSELLN
T
I
L
TR
VGG
P
GNI
A
S
CG
N
C
M
TRLR
L
G
V
H
D
SSLVDPN-
IK
TLE
GV
K
GV
IL
T
SD
Q
V
QVV
F
G
PG
K
AH
R
AAK
A
MSELL
G
EAPV
Q
D
AAEIAAQNKRQLKAKQTSG
VQ
QF
L
AKFAT
IF
T
PLIP
GF
I
AA
GLLLG
IAT
LI
--------
A
T
VMHVPADA
Q
G
T
LPDA
L
N
F
M
KVF
S
K
G
L
F
T
FL
V
I
L
V
GY
N
A
AQA
FGGT
GVN
G
AI
IA
AL
FLLGY
N
P
AATTGYYA
G
FH-----
-
DF
FGL
PI
---D
P
RGN
I
I
G
V
L
IAA
W
A
C
AR
IE
GM
V
RRFM
P
DDLDMLLT
S
L
IT
LLI
TAT
LA
Y
L
I
I
M
P
L
G
G
W
L
FEG
M
S
WLFMH
L
NS--
-
NPFGC
AV
L
A
G
L
F
LIA
V
V
F
GVH
QGFI
P
VY
L
ALM
--
DSQ
G
FNS
L
F
P
I
L
SM
A
GA
G
Q
fig|344601.5.peg.1616
Escherichia coli B171 (1-346/474)
MAKEISSELLN
T
I
L
TR
VGG
P
GNI
A
S
CG
N
C
M
TRLR
L
G
V
H
D
SSLVDPN-
IK
TLE
GV
K
GV
IL
T
SD
Q
V
QVV
F
G
PG
K
AH
R
AAK
A
MSELL
G
EAPV
Q
D
AAEIAAQNKRQLKAKQTSG
VQ
QF
L
AKFAT
IF
T
PLIP
GF
I
AA
GLLLG
IAT
LI
--------
A
T
VMHVPADA
Q
G
T
LPDA
L
N
F
M
KVF
S
K
G
L
F
T
FL
V
I
L
V
GY
N
A
AQA
FGGT
GVN
G
AI
IA
AL
FLLGY
N
P
AATTGYYA
G
FH-----
-
DF
FGL
PI
---D
P
RGN
I
I
G
V
L
IAA
W
A
C
AR
IE
GM
V
RRFM
P
DDLDMLLT
S
L
IT
LLI
TAT
LA
Y
L
I
I
M
P
L
G
G
W
L
FEG
M
S
WLFMH
L
NS--
-
NPFGC
AV
L
A
G
L
F
LIA
V
V
F
GVH
QGFI
P
VY
L
ALM
--
DSQ
G
FNS
L
F
P
I
L
SM
A
GA
G
Q
fig|595496.3.peg.2405
Escherichia coli BW2952 (1-346/474)
MAKEISSELLN
T
I
L
TR
VGG
P
GNI
A
S
CG
N
C
M
TRLR
L
G
V
H
D
SSLVDPN-
IK
TLE
GV
K
GV
IL
T
SD
Q
V
QVV
F
G
PG
K
AH
R
AAK
A
MSELL
G
EAPV
Q
D
AAEIAAQNKRQLKAKQTSG
VQ
QF
L
AKFAT
IF
T
PLIP
GF
I
AA
GLLLG
IAT
LI
--------
A
T
VMHVPADA
Q
G
T
LPDA
L
N
F
M
KVF
S
K
G
L
F
T
FL
V
I
L
V
GY
N
A
AQA
FGGT
GVN
G
AI
IA
AL
FLLGY
N
P
AATTGYYA
G
FH-----
-
DF
FGL
PI
---D
P
RGN
I
I
G
V
L
IAA
W
A
C
AR
IE
GM
V
RRFM
P
DDLDMLLT
S
L
IT
LLI
TAT
LA
Y
L
I
I
M
P
L
G
G
W
L
FEG
M
S
WLFMH
L
NS--
-
NPFGC
AV
L
A
G
L
F
LIA
V
V
F
GVH
QGFI
P
VY
L
ALM
--
DSQ
G
FNS
L
F
P
I
L
SM
A
GA
G
Q
fig|536056.3.peg.1296
Escherichia coli DH1 (1-346/474)
MAKEISSELLN
T
I
L
TR
VGG
P
GNI
A
S
CG
N
C
M
TRLR
L
G
V
H
D
SSLVDPN-
IK
TLE
GV
K
GV
IL
T
SD
Q
V
QVV
F
G
PG
K
AH
R
AAK
A
MSELL
G
EAPV
Q
D
AAEIAAQNKRQLKAKQTSG
VQ
QF
L
AKFAT
IF
T
PLIP
GF
I
AA
GLLLG
IAT
LI
--------
A
T
VMHVPADA
Q
G
T
LPDA
L
N
F
M
KVF
S
K
G
L
F
T
FL
V
I
L
V
GY
N
A
AQA
FGGT
GVN
G
AI
IA
AL
FLLGY
N
P
AATTGYYA
G
FH-----
-
DF
FGL
PI
---D
P
RGN
I
I
G
V
L
IAA
W
A
C
AR
IE
GM
V
RRFM
P
DDLDMLLT
S
L
IT
LLI
TAT
LA
Y
L
I
I
M
P
L
G
G
W
L
FEG
M
S
WLFMH
L
NS--
-
NPFGC
AV
L
A
G
L
F
LIA
V
V
F
GVH
QGFI
P
VY
L
ALM
--
DSQ
G
FNS
L
F
P
I
L
SM
A
GA
G
Q
fig|340186.3.peg.1619
Escherichia coli E110019 (1-346/474)
MAKEISSELLN
T
I
L
TR
VGG
P
GNI
A
S
CG
N
C
M
TRLR
L
G
V
H
D
SSLVDPN-
IK
TLE
GV
K
GV
IL
T
SD
Q
V
QVV
F
G
PG
K
AH
R
AAK
A
MSELL
G
EAPV
Q
D
AAEIAAQNKRQLKAKQTSG
VQ
QF
L
AKFAT
IF
T
PLIP
GF
I
AA
GLLLG
IAT
LI
--------
A
T
VMHVPADA
Q
G
T
LPDA
L
N
F
M
KVF
S
K
G
L
F
T
FL
V
I
L
V
GY
N
A
AQA
FGGT
GVN
G
AI
IA
AL
FLLGY
N
P
AATTGYYA
G
FH-----
-
DF
FGL
PI
---D
P
RGN
I
I
G
V
L
IAA
W
A
C
AR
IE
GM
V
RRFM
P
DDLDMLLT
S
L
IT
LLI
TAT
LA
Y
L
I
I
M
P
L
G
G
W
L
FEG
M
S
WLFMH
L
NS--
-
NPFGC
AV
L
A
G
L
F
LIA
V
V
F
GVH
QGFI
P
VY
L
ALM
--
DSQ
G
FNS
L
F
P
I
L
SM
A
GA
G
Q
fig|340186.3.peg.4427
Escherichia coli E110019 (1-346/474)
MAKEISSELLN
T
I
L
TR
VGG
P
GNI
A
S
CG
N
C
M
TRLR
L
G
V
H
D
SSLVDPN-
IK
TLE
GV
K
GV
IL
T
SD
Q
V
QVV
F
G
PG
K
AH
R
AAK
A
MSELL
G
EAPV
Q
D
AAEIAAQNKRQLKAKQTSG
VQ
QF
L
AKFAT
IF
T
PLIP
GF
I
AA
GLLLG
IAT
LI
--------
A
T
VMHVPADA
Q
G
T
LPDA
L
N
F
M
KVF
S
K
G
L
F
T
FL
V
I
L
V
GY
N
A
AQA
FGGT
GVN
G
AI
IA
AL
FLLGY
N
P
AATTGYYA
G
FH-----
-
DF
FGL
PI
---D
P
RGN
I
I
G
V
L
IAA
W
A
C
AR
IE
GM
V
RRFM
P
DDLDMLLT
S
L
IT
LLI
TAT
LA
Y
L
I
I
M
P
L
G
G
W
L
FEG
M
S
WLFMH
L
NS--
-
NPFGC
AV
L
A
G
L
F
LIA
V
V
F
GVH
QGFI
P
VY
L
ALM
--
DSQ
G
FNS
L
F
P
I
L
SM
A
GA
G
Q
fig|340186.3.peg.4927
Escherichia coli E110019 (1-346/474)
MAKEISSELLN
T
I
L
TR
VGG
P
GNI
A
S
CG
N
C
M
TRLR
L
G
V
H
D
SSLVDPN-
IK
TLE
GV
K
GV
IL
T
SD
Q
V
QVV
F
G
PG
K
AH
R
AAK
A
MSELL
G
EAPV
Q
D
AAEIAAQNKRQLKAKQTSG
VQ
QF
L
AKFAT
IF
T
PLIP
GF
I
AA
GLLLG
IAT
LI
--------
A
T
VMHVPADA
Q
G
T
LPDA
L
N
F
M
KVF
S
K
G
L
F
T
FL
V
I
L
V
GY
N
A
AQA
FGGT
GVN
G
AI
IA
AL
FLLGY
N
P
AATTGYYA
G
FH-----
-
DF
FGL
PI
---D
P
RGN
I
I
G
V
L
IAA
W
A
C
AR
IE
GM
V
RRFM
P
DDLDMLLT
S
L
IT
LLI
TAT
LA
Y
L
I
I
M
P
L
G
G
W
L
FEG
M
S
WLFMH
L
NS--
-
NPFGC
AV
L
A
G
L
F
LIA
V
V
F
GVH
QGFI
P
VY
L
ALM
--
DSQ
G
FNS
L
F
P
I
L
SM
A
GA
G
Q
fig|340186.5.peg.1669
Escherichia coli E110019 (1-346/474)
MAKEISSELLN
T
I
L
TR
VGG
P
GNI
A
S
CG
N
C
M
TRLR
L
G
V
H
D
SSLVDPN-
IK
TLE
GV
K
GV
IL
T
SD
Q
V
QVV
F
G
PG
K
AH
R
AAK
A
MSELL
G
EAPV
Q
D
AAEIAAQNKRQLKAKQTSG
VQ
QF
L
AKFAT
IF
T
PLIP
GF
I
AA
GLLLG
IAT
LI
--------
A
T
VMHVPADA
Q
G
T
LPDA
L
N
F
M
KVF
S
K
G
L
F
T
FL
V
I
L
V
GY
N
A
AQA
FGGT
GVN
G
AI
IA
AL
FLLGY
N
P
AATTGYYA
G
FH-----
-
DF
FGL
PI
---D
P
RGN
I
I
G
V
L
IAA
W
A
C
AR
IE
GM
V
RRFM
P
DDLDMLLT
S
L
IT
LLI
TAT
LA
Y
L
I
I
M
P
L
G
G
W
L
FEG
M
S
WLFMH
L
NS--
-
NPFGC
AV
L
A
G
L
F
LIA
V
V
F
GVH
QGFI
P
VY
L
ALM
--
DSQ
G
FNS
L
F
P
I
L
SM
A
GA
G
Q
fig|340186.5.peg.4653
Escherichia coli E110019 (1-346/474)
MAKEISSELLN
T
I
L
TR
VGG
P
GNI
A
S
CG
N
C
M
TRLR
L
G
V
H
D
SSLVDPN-
IK
TLE
GV
K
GV
IL
T
SD
Q
V
QVV
F
G
PG
K
AH
R
AAK
A
MSELL
G
EAPV
Q
D
AAEIAAQNKRQLKAKQTSG
VQ
QF
L
AKFAT
IF
T
PLIP
GF
I
AA
GLLLG
IAT
LI
--------
A
T
VMHVPADA
Q
G
T
LPDA
L
N
F
M
KVF
S
K
G
L
F
T
FL
V
I
L
V
GY
N
A
AQA
FGGT
GVN
G
AI
IA
AL
FLLGY
N
P
AATTGYYA
G
FH-----
-
DF
FGL
PI
---D
P
RGN
I
I
G
V
L
IAA
W
A
C
AR
IE
GM
V
RRFM
P
DDLDMLLT
S
L
IT
LLI
TAT
LA
Y
L
I
I
M
P
L
G
G
W
L
FEG
M
S
WLFMH
L
NS--
-
NPFGC
AV
L
A
G
L
F
LIA
V
V
F
GVH
QGFI
P
VY
L
ALM
--
DSQ
G
FNS
L
F
P
I
L
SM
A
GA
G
Q
fig|340185.3.peg.3088
Escherichia coli E22 (1-346/474)
MAKEISSELLN
T
I
L
TR
VGG
P
GNI
A
S
CG
N
C
M
TRLR
L
G
V
H
D
SSLVDPN-
IK
TLE
GV
K
GV
IL
T
SD
Q
V
QVV
F
G
PG
K
AH
R
AAK
A
MSELL
G
EAPV
Q
D
AAEIAAQNKRQLKAKQTSG
VQ
QF
L
AKFAT
IF
T
PLIP
GF
I
AA
GLLLG
IAT
LI
--------
A
T
VMHVPADA
Q
G
T
LPDA
L
N
F
M
KVF
S
K
G
L
F
T
FL
V
I
L
V
GY
N
A
AQA
FGGT
GVN
G
AI
IA
AL
FLLGY
N
P
AATTGYYA
G
FH-----
-
DF
FGL
PI
---D
P
RGN
I
I
G
V
L
IAA
W
A
C
AR
IE
GM
V
RRFM
P
DDLDMLLT
S
L
IT
LLI
TAT
LA
Y
L
I
I
M
P
L
G
G
W
L
FEG
M
S
WLFMH
L
NS--
-
NPFGC
AV
L
A
G
L
F
LIA
V
V
F
GVH
QGFI
P
VY
L
ALM
--
DSQ
G
FNS
L
F
P
I
L
SM
A
GA
G
Q
fig|340185.4.peg.3252
Escherichia coli E22 (1-346/474)
MAKEISSELLN
T
I
L
TR
VGG
P
GNI
A
S
CG
N
C
M
TRLR
L
G
V
H
D
SSLVDPN-
IK
TLE
GV
K
GV
IL
T
SD
Q
V
QVV
F
G
PG
K
AH
R
AAK
A
MSELL
G
EAPV
Q
D
AAEIAAQNKRQLKAKQTSG
VQ
QF
L
AKFAT
IF
T
PLIP
GF
I
AA
GLLLG
IAT
LI
--------
A
T
VMHVPADA
Q
G
T
LPDA
L
N
F
M
KVF
S
K
G
L
F
T
FL
V
I
L
V
GY
N
A
AQA
FGGT
GVN
G
AI
IA
AL
FLLGY
N
P
AATTGYYA
G
FH-----
-
DF
FGL
PI
---D
P
RGN
I
I
G
V
L
IAA
W
A
C
AR
IE
GM
V
RRFM
P
DDLDMLLT
S
L
IT
LLI
TAT
LA
Y
L
I
I
M
P
L
G
G
W
L
FEG
M
S
WLFMH
L
NS--
-
NPFGC
AV
L
A
G
L
F
LIA
V
V
F
GVH
QGFI
P
VY
L
ALM
--
DSQ
G
FNS
L
F
P
I
L
SM
A
GA
G
Q
fig|331111.12.peg.2985
Escherichia coli E24377A (1-346/474)
MAKEISSELLN
T
I
L
TR
VGG
P
GNI
A
S
CG
N
C
M
TRLR
L
G
V
H
D
SSLVDPN-
IK
TLE
GV
K
GV
IL
T
SD
Q
V
QVV
F
G
PG
K
AH
R
AAK
A
MSELL
G
EAPV
Q
D
AAEIAAQNKRQLKAKQTSG
VQ
QF
L
AKFAT
IF
T
PLIP
GF
I
AA
GLLLG
IAT
LI
--------
A
T
VMHVPADA
Q
G
T
LPDA
L
N
F
M
KVF
S
K
G
L
F
T
FL
V
I
L
V
GY
N
A
AQA
FGGT
GVN
G
AI
IA
AL
FLLGY
N
P
AATTGYYA
G
FH-----
-
DF
FGL
PI
---D
P
RGN
I
I
G
V
L
IAA
W
A
C
AR
IE
GM
V
RRFM
P
DDLDMLLT
S
L
IT
LLI
TAT
LA
Y
L
I
I
M
P
L
G
G
W
L
FEG
M
S
WLFMH
L
NS--
-
NPFGC
AV
L
A
G
L
F
LIA
V
V
F
GVH
QGFI
P
VY
L
ALM
--
DSQ
G
FNS
L
F
P
I
L
SM
A
GA
G
Q
fig|331111.3.peg.437
Escherichia coli E24377A (1-346/474)
MAKEISSELLN
T
I
L
TR
VGG
P
GNI
A
S
CG
N
C
M
TRLR
L
G
V
H
D
SSLVDPN-
IK
TLE
GV
K
GV
IL
T
SD
Q
V
QVV
F
G
PG
K
AH
R
AAK
A
MSELL
G
EAPV
Q
D
AAEIAAQNKRQLKAKQTSG
VQ
QF
L
AKFAT
IF
T
PLIP
GF
I
AA
GLLLG
IAT
LI
--------
A
T
VMHVPADA
Q
G
T
LPDA
L
N
F
M
KVF
S
K
G
L
F
T
FL
V
I
L
V
GY
N
A
AQA
FGGT
GVN
G
AI
IA
AL
FLLGY
N
P
AATTGYYA
G
FH-----
-
DF
FGL
PI
---D
P
RGN
I
I
G
V
L
IAA
W
A
C
AR
IE
GM
V
RRFM
P
DDLDMLLT
S
L
IT
LLI
TAT
LA
Y
L
I
I
M
P
L
G
G
W
L
FEG
M
S
WLFMH
L
NS--
-
NPFGC
AV
L
A
G
L
F
LIA
V
V
F
GVH
QGFI
P
VY
L
ALM
--
DSQ
G
FNS
L
F
P
I
L
SM
A
GA
G
Q
fig|562.375.peg.3408
Escherichia coli EC4100B (1-346/474)
MAKEISSELLN
T
I
L
TR
VGG
P
GNI
A
S
CG
N
C
M
TRLR
L
G
V
H
D
SSLVDPN-
IK
TLE
GV
K
GV
IL
T
SD
Q
V
QVV
F
G
PG
K
AH
R
AAK
A
MSELL
G
EAPV
Q
D
AAEIAAQNKRQLKAKQTSG
VQ
QF
L
AKFAT
IF
T
PLIP
GF
I
AA
GLLLG
IAT
LI
--------
A
T
VMHVPADA
Q
G
T
LPDA
L
N
F
M
KVF
S
K
G
L
F
T
FL
V
I
L
V
GY
N
A
AQA
FGGT
GVN
G
AI
IA
AL
FLLGY
N
P
AATTGYYA
G
FH-----
-
DF
FGL
PI
---D
P
RGN
I
I
G
V
L
IAA
W
A
C
AR
IE
GM
V
RRFM
P
DDLDMLLT
S
L
IT
LLI
TAT
LA
Y
L
I
I
M
P
L
G
G
W
L
FEG
M
S
WLFMH
L
NS--
-
NPFGC
AV
L
A
G
L
F
LIA
V
V
F
GVH
QGFI
P
VY
L
ALM
--
DSQ
G
FNS
L
F
P
I
L
SM
A
GA
G
Q
fig|316401.4.peg.2904
Escherichia coli ETEC H10407 (1-346/474)
MAKEISSELLN
T
I
L
TR
VGG
P
GNI
A
S
CG
N
C
M
TRLR
L
G
V
H
D
SSLVDPN-
IK
TLE
GV
K
GV
IL
T
SD
Q
V
QVV
F
G
PG
K
AH
R
AAK
A
MSELL
G
EAPV
Q
D
AAEIAAQNKRQLKAKQTSG
VQ
QF
L
AKFAT
IF
T
PLIP
GF
I
AA
GLLLG
IAT
LI
--------
A
T
VMHVPADA
Q
G
T
LPDA
L
N
F
M
KVF
S
K
G
L
F
T
FL
V
I
L
V
GY
N
A
AQA
FGGT
GVN
G
AI
IA
AL
FLLGY
N
P
AATTGYYA
G
FH-----
-
DF
FGL
PI
---D
P
RGN
I
I
G
V
L
IAA
W
A
C
AR
IE
GM
V
RRFM
P
DDLDMLLT
S
L
IT
LLI
TAT
LA
Y
L
I
I
M
P
L
G
G
W
L
FEG
M
S
WLFMH
L
NS--
-
NPFGC
AV
L
A
G
L
F
LIA
V
V
F
GVH
QGFI
P
VY
L
ALM
--
DSQ
G
FNS
L
F
P
I
L
SM
A
GA
G
Q
fig|656408.3.peg.2716
Escherichia coli H591 (1-346/474)
MAKEISSELLN
T
I
L
TR
VGG
P
GNI
A
S
CG
N
C
M
TRLR
L
G
V
H
D
SSLVDPN-
IK
TLE
GV
K
GV
IL
T
SD
Q
V
QVV
F
G
PG
K
AH
R
AAK
A
MSELL
G
EAPV
Q
D
AAEIAAQNKRQLKAKQTSG
VQ
QF
L
AKFAT
IF
T
PLIP
GF
I
AA
GLLLG
IAT
LI
--------
A
T
VMHVPADA
Q
G
T
LPDA
L
N
F
M
KVF
S
K
G
L
F
T
FL
V
I
L
V
GY
N
A
AQA
FGGT
GVN
G
AI
IA
AL
FLLGY
N
P
AATTGYYA
G
FH-----
-
DF
FGL
PI
---D
P
RGN
I
I
G
V
L
IAA
W
A
C
AR
IE
GM
V
RRFM
P
DDLDMLLT
S
L
IT
LLI
TAT
LA
Y
L
I
I
M
P
L
G
G
W
L
FEG
M
S
WLFMH
L
NS--
-
NPFGC
AV
L
A
G
L
F
LIA
V
V
F
GVH
QGFI
P
VY
L
ALM
--
DSQ
G
FNS
L
F
P
I
L
SM
A
GA
G
Q
fig|656414.3.peg.2801
Escherichia coli H736 (1-346/474)
MAKEISSELLN
T
I
L
TR
VGG
P
GNI
A
S
CG
N
C
M
TRLR
L
G
V
H
D
SSLVDPN-
IK
TLE
GV
K
GV
IL
T
SD
Q
V
QVV
F
G
PG
K
AH
R
AAK
A
MSELL
G
EAPV
Q
D
AAEIAAQNKRQLKAKQTSG
VQ
QF
L
AKFAT
IF
T
PLIP
GF
I
AA
GLLLG
IAT
LI
--------
A
T
VMHVPADA
Q
G
T
LPDA
L
N
F
M
KVF
S
K
G
L
F
T
FL
V
I
L
V
GY
N
A
AQA
FGGT
GVN
G
AI
IA
AL
FLLGY
N
P
AATTGYYA
G
FH-----
-
DF
FGL
PI
---D
P
RGN
I
I
G
V
L
IAA
W
A
C
AR
IE
GM
V
RRFM
P
DDLDMLLT
S
L
IT
LLI
TAT
LA
Y
L
I
I
M
P
L
G
G
W
L
FEG
M
S
WLFMH
L
NS--
-
NPFGC
AV
L
A
G
L
F
LIA
V
V
F
GVH
QGFI
P
VY
L
ALM
--
DSQ
G
FNS
L
F
P
I
L
SM
A
GA
G
Q
fig|331112.3.peg.2404
Escherichia coli HS (1-346/474)
MAKEISSELLN
T
I
L
TR
VGG
P
GNI
A
S
CG
N
C
M
TRLR
L
G
V
H
D
SSLVDPN-
IK
TLE
GV
K
GV
IL
T
SD
Q
V
QVV
F
G
PG
K
AH
R
AAK
A
MSELL
G
EAPV
Q
D
AAEIAAQNKRQLKAKQTSG
VQ
QF
L
AKFAT
IF
T
PLIP
GF
I
AA
GLLLG
IAT
LI
--------
A
T
VMHVPADA
Q
G
T
LPDA
L
N
F
M
KVF
S
K
G
L
F
T
FL
V
I
L
V
GY
N
A
AQA
FGGT
GVN
G
AI
IA
AL
FLLGY
N
P
AATTGYYA
G
FH-----
-
DF
FGL
PI
---D
P
RGN
I
I
G
V
L
IAA
W
A
C
AR
IE
GM
V
RRFM
P
DDLDMLLT
S
L
IT
LLI
TAT
LA
Y
L
I
I
M
P
L
G
G
W
L
FEG
M
S
WLFMH
L
NS--
-
NPFGC
AV
L
A
G
L
F
LIA
V
V
F
GVH
QGFI
P
VY
L
ALM
--
DSQ
G
FNS
L
F
P
I
L
SM
A
GA
G
Q
fig|331112.6.peg.2509
Escherichia coli HS (1-346/474)
MAKEISSELLN
T
I
L
TR
VGG
P
GNI
A
S
CG
N
C
M
TRLR
L
G
V
H
D
SSLVDPN-
IK
TLE
GV
K
GV
IL
T
SD
Q
V
QVV
F
G
PG
K
AH
R
AAK
A
MSELL
G
EAPV
Q
D
AAEIAAQNKRQLKAKQTSG
VQ
QF
L
AKFAT
IF
T
PLIP
GF
I
AA
GLLLG
IAT
LI
--------
A
T
VMHVPADA
Q
G
T
LPDA
L
N
F
M
KVF
S
K
G
L
F
T
FL
V
I
L
V
GY
N
A
AQA
FGGT
GVN
G
AI
IA
AL
FLLGY
N
P
AATTGYYA
G
FH-----
-
DF
FGL
PI
---D
P
RGN
I
I
G
V
L
IAA
W
A
C
AR
IE
GM
V
RRFM
P
DDLDMLLT
S
L
IT
LLI
TAT
LA
Y
L
I
I
M
P
L
G
G
W
L
FEG
M
S
WLFMH
L
NS--
-
NPFGC
AV
L
A
G
L
F
LIA
V
V
F
GVH
QGFI
P
VY
L
ALM
--
DSQ
G
FNS
L
F
P
I
L
SM
A
GA
G
Q
fig|585034.4.peg.2451
Escherichia coli IAI1 (1-346/474)
MAKEISSELLN
T
I
L
TR
VGG
P
GNI
A
S
CG
N
C
M
TRLR
L
G
V
H
D
SSLVDPN-
IK
TLE
GV
K
GV
IL
T
SD
Q
V
QVV
F
G
PG
K
AH
R
AAK
A
MSELL
G
EAPV
Q
D
AAEIAAQNKRQLKAKQTSG
VQ
QF
L
AKFAT
IF
T
PLIP
GF
I
AA
GLLLG
IAT
LI
--------
A
T
VMHVPADA
Q
G
T
LPDA
L
N
F
M
KVF
S
K
G
L
F
T
FL
V
I
L
V
GY
N
A
AQA
FGGT
GVN
G
AI
IA
AL
FLLGY
N
P
AATTGYYA
G
FH-----
-
DF
FGL
PI
---D
P
RGN
I
I
G
V
L
IAA
W
A
C
AR
IE
GM
V
RRFM
P
DDLDMLLT
S
L
IT
LLI
TAT
LA
Y
L
I
I
M
P
L
G
G
W
L
FEG
M
S
WLFMH
L
NS--
-
NPFGC
AV
L
A
G
L
F
LIA
V
V
F
GVH
QGFI
P
VY
L
ALM
--
DSQ
G
FNS
L
F
P
I
L
SM
A
GA
G
Q
fig|585034.5.peg.2449
Escherichia coli IAI1 (1-346/474)
MAKEISSELLN
T
I
L
TR
VGG
P
GNI
A
S
CG
N
C
M
TRLR
L
G
V
H
D
SSLVDPN-
IK
TLE
GV
K
GV
IL
T
SD
Q
V
QVV
F
G
PG
K
AH
R
AAK
A
MSELL
G
EAPV
Q
D
AAEIAAQNKRQLKAKQTSG
VQ
QF
L
AKFAT
IF
T
PLIP
GF
I
AA
GLLLG
IAT
LI
--------
A
T
VMHVPADA
Q
G
T
LPDA
L
N
F
M
KVF
S
K
G
L
F
T
FL
V
I
L
V
GY
N
A
AQA
FGGT
GVN
G
AI
IA
AL
FLLGY
N
P
AATTGYYA
G
FH-----
-
DF
FGL
PI
---D
P
RGN
I
I
G
V
L
IAA
W
A
C
AR
IE
GM
V
RRFM
P
DDLDMLLT
S
L
IT
LLI
TAT
LA
Y
L
I
I
M
P
L
G
G
W
L
FEG
M
S
WLFMH
L
NS--
-
NPFGC
AV
L
A
G
L
F
LIA
V
V
F
GVH
QGFI
P
VY
L
ALM
--
DSQ
G
FNS
L
F
P
I
L
SM
A
GA
G
Q
fig|83333.1.peg.2397
Escherichia coli K12 (1-346/474)
MAKEISSELLN
T
I
L
TR
VGG
P
GNI
A
S
CG
N
C
M
TRLR
L
G
V
H
D
SSLVDPN-
IK
TLE
GV
K
GV
IL
T
SD
Q
V
QVV
F
G
PG
K
AH
R
AAK
A
MSELL
G
EAPV
Q
D
AAEIAAQNKRQLKAKQTSG
VQ
QF
L
AKFAT
IF
T
PLIP
GF
I
AA
GLLLG
IAT
LI
--------
A
T
VMHVPADA
Q
G
T
LPDA
L
N
F
M
KVF
S
K
G
L
F
T
FL
V
I
L
V
GY
N
A
AQA
FGGT
GVN
G
AI
IA
AL
FLLGY
N
P
AATTGYYA
G
FH-----
-
DF
FGL
PI
---D
P
RGN
I
I
G
V
L
IAA
W
A
C
AR
IE
GM
V
RRFM
P
DDLDMLLT
S
L
IT
LLI
TAT
LA
Y
L
I
I
M
P
L
G
G
W
L
FEG
M
S
WLFMH
L
NS--
-
NPFGC
AV
L
A
G
L
F
LIA
V
V
F
GVH
QGFI
P
VY
L
ALM
--
DSQ
G
FNS
L
F
P
I
L
SM
A
GA
G
Q
fig|595495.4.peg.2540
Escherichia coli KO11 (1-346/474)
MAKEISSELLN
T
I
L
TR
VGG
P
GNI
A
S
CG
N
C
M
TRLR
L
G
V
H
D
SSLVDPN-
IK
TLE
GV
K
GV
IL
T
SD
Q
V
QVV
F
G
PG
K
AH
R
AAK
A
MSELL
G
EAPV
Q
D
AAEIAAQNKRQLKAKQTSG
VQ
QF
L
AKFAT
IF
T
PLIP
GF
I
AA
GLLLG
IAT
LI
--------
A
T
VMHVPADA
Q
G
T
LPDA
L
N
F
M
KVF
S
K
G
L
F
T
FL
V
I
L
V
GY
N
A
AQA
FGGT
GVN
G
AI
IA
AL
FLLGY
N
P
AATTGYYA
G
FH-----
-
DF
FGL
PI
---D
P
RGN
I
I
G
V
L
IAA
W
A
C
AR
IE
GM
V
RRFM
P
DDLDMLLT
S
L
IT
LLI
TAT
LA
Y
L
I
I
M
P
L
G
G
W
L
FEG
M
S
WLFMH
L
NS--
-
NPFGC
AV
L
A
G
L
F
LIA
V
V
F
GVH
QGFI
P
VY
L
ALM
--
DSQ
G
FNS
L
F
P
I
L
SM
A
GA
G
Q
fig|679207.4.peg.2333
Escherichia coli MS 107-1 (1-346/474)
MAKEISSELLN
T
I
L
TR
VGG
P
GNI
A
S
CG
N
C
M
TRLR
L
G
V
H
D
SSLVDPN-
IK
TLE
GV
K
GV
IL
T
SD
Q
V
QVV
F
G
PG
K
AH
R
AAK
A
MSELL
G
EAPV
Q
D
AAEIAAQNKRQLKAKQTSG
VQ
QF
L
AKFAT
IF
T
PLIP
GF
I
AA
GLLLG
IAT
LI
--------
A
T
VMHVPADA
Q
G
T
LPDA
L
N
F
M
KVF
S
K
G
L
F
T
FL
V
I
L
V
GY
N
A
AQA
FGGT
GVN
G
AI
IA
AL
FLLGY
N
P
AATTGYYA
G
FH-----
-
DF
FGL
PI
---D
P
RGN
I
I
G
V
L
IAA
W
A
C
AR
IE
GM
V
RRFM
P
DDLDMLLT
S
L
IT
LLI
TAT
LA
Y
L
I
I
M
P
L
G
G
W
L
FEG
M
S
WLFMH
L
NS--
-
NPFGC
AV
L
A
G
L
F
LIA
V
V
F
GVH
QGFI
P
VY
L
ALM
--
DSQ
G
FNS
L
F
P
I
L
SM
A
GA
G
Q
fig|749537.3.peg.4730
Escherichia coli MS 115-1 (1-346/474)
MAKEISSELLN
T
I
L
TR
VGG
P
GNI
A
S
CG
N
C
M
TRLR
L
G
V
H
D
SSLVDPN-
IK
TLE
GV
K
GV
IL
T
SD
Q
V
QVV
F
G
PG
K
AH
R
AAK
A
MSELL
G
EAPV
Q
D
AAEIAAQNKRQLKAKQTSG
VQ
QF
L
AKFAT
IF
T
PLIP
GF
I
AA
GLLLG
IAT
LI
--------
A
T
VMHVPADA
Q
G
T
LPDA
L
N
F
M
KVF
S
K
G
L
F
T
FL
V
I
L
V
GY
N
A
AQA
FGGT
GVN
G
AI
IA
AL
FLLGY
N
P
AATTGYYA
G
FH-----
-
DF
FGL
PI
---D
P
RGN
I
I
G
V
L
IAA
W
A
C
AR
IE
GM
V
RRFM
P
DDLDMLLT
S
L
IT
LLI
TAT
LA
Y
L
I
I
M
P
L
G
G
W
L
FEG
M
S
WLFMH
L
NS--
-
NPFGC
AV
L
A
G
L
F
LIA
V
V
F
GVH
QGFI
P
VY
L
ALM
--
DSQ
G
FNS
L
F
P
I
L
SM
A
GA
G
Q
fig|679206.4.peg.683
Escherichia coli MS 119-7 (1-346/474)
MAKEISSELLN
T
I
L
TR
VGG
P
GNI
A
S
CG
N
C
M
TRLR
L
G
V
H
D
SSLVDPN-
IK
TLE
GV
K
GV
IL
T
SD
Q
V
QVV
F
G
PG
K
AH
R
AAK
A
MSELL
G
EAPV
Q
D
AAEIAAQNKRQLKAKQTSG
VQ
QF
L
AKFAT
IF
T
PLIP
GF
I
AA
GLLLG
IAT
LI
--------
A
T
VMHVPADA
Q
G
T
LPDA
L
N
F
M
KVF
S
K
G
L
F
T
FL
V
I
L
V
GY
N
A
AQA
FGGT
GVN
G
AI
IA
AL
FLLGY
N
P
AATTGYYA
G
FH-----
-
DF
FGL
PI
---D
P
RGN
I
I
G
V
L
IAA
W
A
C
AR
IE
GM
V
RRFM
P
DDLDMLLT
S
L
IT
LLI
TAT
LA
Y
L
I
I
M
P
L
G
G
W
L
FEG
M
S
WLFMH
L
NS--
-
NPFGC
AV
L
A
G
L
F
LIA
V
V
F
GVH
QGFI
P
VY
L
ALM
--
DSQ
G
FNS
L
F
P
I
L
SM
A
GA
G
Q
fig|679205.4.peg.4708
Escherichia coli MS 124-1 (1-346/474)
MAKEISSELLN
T
I
L
TR
VGG
P
GNI
A
S
CG
N
C
M
TRLR
L
G
V
H
D
SSLVDPN-
IK
TLE
GV
K
GV
IL
T
SD
Q
V
QVV
F
G
PG
K
AH
R
AAK
A
MSELL
G
EAPV
Q
D
AAEIAAQNKRQLKAKQTSG
VQ
QF
L
AKFAT
IF
T
PLIP
GF
I
AA
GLLLG
IAT
LI
--------
A
T
VMHVPADA
Q
G
T
LPDA
L
N
F
M
KVF
S
K
G
L
F
T
FL
V
I
L
V
GY
N
A
AQA
FGGT
GVN
G
AI
IA
AL
FLLGY
N
P
AATTGYYA
G
FH-----
-
DF
FGL
PI
---D
P
RGN
I
I
G
V
L
IAA
W
A
C
AR
IE
GM
V
RRFM
P
DDLDMLLT
S
L
IT
LLI
TAT
LA
Y
L
I
I
M
P
L
G
G
W
L
FEG
M
S
WLFMH
L
NS--
-
NPFGC
AV
L
A
G
L
F
LIA
V
V
F
GVH
QGFI
P
VY
L
ALM
--
DSQ
G
FNS
L
F
P
I
L
SM
A
GA
G
Q
fig|749540.3.peg.4387
Escherichia coli MS 146-1 (1-346/474)
MAKEISSELLN
T
I
L
TR
VGG
P
GNI
A
S
CG
N
C
M
TRLR
L
G
V
H
D
SSLVDPN-
IK
TLE
GV
K
GV
IL
T
SD
Q
V
QVV
F
G
PG
K
AH
R
AAK
A
MSELL
G
EAPV
Q
D
AAEIAAQNKRQLKAKQTSG
VQ
QF
L
AKFAT
IF
T
PLIP
GF
I
AA
GLLLG
IAT
LI
--------
A
T
VMHVPADA
Q
G
T
LPDA
L
N
F
M
KVF
S
K
G
L
F
T
FL
V
I
L
V
GY
N
A
AQA
FGGT
GVN
G
AI
IA
AL
FLLGY
N
P
AATTGYYA
G
FH-----
-
DF
FGL
PI
---D
P
RGN
I
I
G
V
L
IAA
W
A
C
AR
IE
GM
V
RRFM
P
DDLDMLLT
S
L
IT
LLI
TAT
LA
Y
L
I
I
M
P
L
G
G
W
L
FEG
M
S
WLFMH
L
NS--
-
NPFGC
AV
L
A
G
L
F
LIA
V
V
F
GVH
QGFI
P
VY
L
ALM
--
DSQ
G
FNS
L
F
P
I
L
SM
A
GA
G
Q
fig|749545.3.peg.386
Escherichia coli MS 182-1 (1-346/474)
MAKEISSELLN
T
I
L
TR
VGG
P
GNI
A
S
CG
N
C
M
TRLR
L
G
V
H
D
SSLVDPN-
IK
TLE
GV
K
GV
IL
T
SD
Q
V
QVV
F
G
PG
K
AH
R
AAK
A
MSELL
G
EAPV
Q
D
AAEIAAQNKRQLKAKQTSG
VQ
QF
L
AKFAT
IF
T
PLIP
GF
I
AA
GLLLG
IAT
LI
--------
A
T
VMHVPADA
Q
G
T
LPDA
L
N
F
M
KVF
S
K
G
L
F
T
FL
V
I
L
V
GY
N
A
AQA
FGGT
GVN
G
AI
IA
AL
FLLGY
N
P
AATTGYYA
G
FH-----
-
DF
FGL
PI
---D
P
RGN
I
I
G
V
L
IAA
W
A
C
AR
IE
GM
V
RRFM
P
DDLDMLLT
S
L
IT
LLI
TAT
LA
Y
L
I
I
M
P
L
G
G
W
L
FEG
M
S
WLFMH
L
NS--
-
NPFGC
AV
L
A
G
L
F
LIA
V
V
F
GVH
QGFI
P
VY
L
ALM
--
DSQ
G
FNS
L
F
P
I
L
SM
A
GA
G
Q
fig|749548.3.peg.1962
Escherichia coli MS 196-1 (1-346/474)
MAKEISSELLN
T
I
L
TR
VGG
P
GNI
A
S
CG
N
C
M
TRLR
L
G
V
H
D
SSLVDPN-
IK
TLE
GV
K
GV
IL
T
SD
Q
V
QVV
F
G
PG
K
AH
R
AAK
A
MSELL
G
EAPV
Q
D
AAEIAAQNKRQLKAKQTSG
VQ
QF
L
AKFAT
IF
T
PLIP
GF
I
AA
GLLLG
IAT
LI
--------
A
T
VMHVPADA
Q
G
T
LPDA
L
N
F
M
KVF
S
K
G
L
F
T
FL
V
I
L
V
GY
N
A
AQA
FGGT
GVN
G
AI
IA
AL
FLLGY
N
P
AATTGYYA
G
FH-----
-
DF
FGL
PI
---D
P
RGN
I
I
G
V
L
IAA
W
A
C
AR
IE
GM
V
RRFM
P
DDLDMLLT
S
L
IT
LLI
TAT
LA
Y
L
I
I
M
P
L
G
G
W
L
FEG
M
S
WLFMH
L
NS--
-
NPFGC
AV
L
A
G
L
F
LIA
V
V
F
GVH
QGFI
P
VY
L
ALM
--
DSQ
G
FNS
L
F
P
I
L
SM
A
GA
G
Q
fig|749533.3.peg.1228
Escherichia coli MS 84-1 (1-346/474)
MAKEISSELLN
T
I
L
TR
VGG
P
GNI
A
S
CG
N
C
M
TRLR
L
G
V
H
D
SSLVDPN-
IK
TLE
GV
K
GV
IL
T
SD
Q
V
QVV
F
G
PG
K
AH
R
AAK
A
MSELL
G
EAPV
Q
D
AAEIAAQNKRQLKAKQTSG
VQ
QF
L
AKFAT
IF
T
PLIP
GF
I
AA
GLLLG
IAT
LI
--------
A
T
VMHVPADA
Q
G
T
LPDA
L
N
F
M
KVF
S
K
G
L
F
T
FL
V
I
L
V
GY
N
A
AQA
FGGT
GVN
G
AI
IA
AL
FLLGY
N
P
AATTGYYA
G
FH-----
-
DF
FGL
PI
---D
P
RGN
I
I
G
V
L
IAA
W
A
C
AR
IE
GM
V
RRFM
P
DDLDMLLT
S
L
IT
LLI
TAT
LA
Y
L
I
I
M
P
L
G
G
W
L
FEG
M
S
WLFMH
L
NS--
-
NPFGC
AV
L
A
G
L
F
LIA
V
V
F
GVH
QGFI
P
VY
L
ALM
--
DSQ
G
FNS
L
F
P
I
L
SM
A
GA
G
Q
fig|585395.4.peg.3084
Escherichia coli O103:H2 str. 12009 (1-346/474)
MAKEISSELLN
T
I
L
TR
VGG
P
GNI
A
S
CG
N
C
M
TRLR
L
G
V
H
D
SSLVDPN-
IK
TLE
GV
K
GV
IL
T
SD
Q
V
QVV
F
G
PG
K
AH
R
AAK
A
MSELL
G
EAPV
Q
D
AAEIAAQNKRQLKAKQTSG
VQ
QF
L
AKFAT
IF
T
PLIP
GF
I
AA
GLLLG
IAT
LI
--------
A
T
VMHVPADA
Q
G
T
LPDA
L
N
F
M
KVF
S
K
G
L
F
T
FL
V
I
L
V
GY
N
A
AQA
FGGT
GVN
G
AI
IA
AL
FLLGY
N
P
AATTGYYA
G
FH-----
-
DF
FGL
PI
---D
P
RGN
I
I
G
V
L
IAA
W
A
C
AR
IE
GM
V
RRFM
P
DDLDMLLT
S
L
IT
LLI
TAT
LA
Y
L
I
I
M
P
L
G
G
W
L
FEG
M
S
WLFMH
L
NS--
-
NPFGC
AV
L
A
G
L
F
LIA
V
V
F
GVH
QGFI
P
VY
L
ALM
--
DSQ
G
FNS
L
F
P
I
L
SM
A
GA
G
Q
fig|585396.4.peg.3257
Escherichia coli O111:H- str. 11128 (1-346/474)
MAKEISSELLN
T
I
L
TR
VGG
P
GNI
A
S
CG
N
C
M
TRLR
L
G
V
H
D
SSLVDPN-
IK
TLE
GV
K
GV
IL
T
SD
Q
V
QVV
F
G
PG
K
AH
R
AAK
A
MSELL
G
EAPV
Q
D
AAEIAAQNKRQLKAKQTSG
VQ
QF
L
AKFAT
IF
T
PLIP
GF
I
AA
GLLLG
IAT
LI
--------
A
T
VMHVPADA
Q
G
T
LPDA
L
N
F
M
KVF
S
K
G
L
F
T
FL
V
I
L
V
GY
N
A
AQA
FGGT
GVN
G
AI
IA
AL
FLLGY
N
P
AATTGYYA
G
FH-----
-
DF
FGL
PI
---D
P
RGN
I
I
G
V
L
IAA
W
A
C
AR
IE
GM
V
RRFM
P
DDLDMLLT
S
L
IT
LLI
TAT
LA
Y
L
I
I
M
P
L
G
G
W
L
FEG
M
S
WLFMH
L
NS--
-
NPFGC
AV
L
A
G
L
F
LIA
V
V
F
GVH
QGFI
P
VY
L
ALM
--
DSQ
G
FNS
L
F
P
I
L
SM
A
GA
G
Q
fig|573235.3.peg.3545
Escherichia coli O26:H11 str. 11368 (1-346/474)
MAKEISSELLN
T
I
L
TR
VGG
P
GNI
A
S
CG
N
C
M
TRLR
L
G
V
H
D
SSLVDPN-
IK
TLE
GV
K
GV
IL
T
SD
Q
V
QVV
F
G
PG
K
AH
R
AAK
A
MSELL
G
EAPV
Q
D
AAEIAAQNKRQLKAKQTSG
VQ
QF
L
AKFAT
IF
T
PLIP
GF
I
AA
GLLLG
IAT
LI
--------
A
T
VMHVPADA
Q
G
T
LPDA
L
N
F
M
KVF
S
K
G
L
F
T
FL
V
I
L
V
GY
N
A
AQA
FGGT
GVN
G
AI
IA
AL
FLLGY
N
P
AATTGYYA
G
FH-----
-
DF
FGL
PI
---D
P
RGN
I
I
G
V
L
IAA
W
A
C
AR
IE
GM
V
RRFM
P
DDLDMLLT
S
L
IT
LLI
TAT
LA
Y
L
I
I
M
P
L
G
G
W
L
FEG
M
S
WLFMH
L
NS--
-
NPFGC
AV
L
A
G
L
F
LIA
V
V
F
GVH
QGFI
P
VY
L
ALM
--
DSQ
G
FNS
L
F
P
I
L
SM
A
GA
G
Q
fig|409438.11.peg.2884
Escherichia coli SE11 (1-346/474)
MAKEISSELLN
T
I
L
TR
VGG
P
GNI
A
S
CG
N
C
M
TRLR
L
G
V
H
D
SSLVDPN-
IK
TLE
GV
K
GV
IL
T
SD
Q
V
QVV
F
G
PG
K
AH
R
AAK
A
MSELL
G
EAPV
Q
D
AAEIAAQNKRQLKAKQTSG
VQ
QF
L
AKFAT
IF
T
PLIP
GF
I
AA
GLLLG
IAT
LI
--------
A
T
VMHVPADA
Q
G
T
LPDA
L
N
F
M
KVF
S
K
G
L
F
T
FL
V
I
L
V
GY
N
A
AQA
FGGT
GVN
G
AI
IA
AL
FLLGY
N
P
AATTGYYA
G
FH-----
-
DF
FGL
PI
---D
P
RGN
I
I
G
V
L
IAA
W
A
C
AR
IE
GM
V
RRFM
P
DDLDMLLT
S
L
IT
LLI
TAT
LA
Y
L
I
I
M
P
L
G
G
W
L
FEG
M
S
WLFMH
L
NS--
-
NPFGC
AV
L
A
G
L
F
LIA
V
V
F
GVH
QGFI
P
VY
L
ALM
--
DSQ
G
FNS
L
F
P
I
L
SM
A
GA
G
Q
fig|656443.3.peg.3181
Escherichia coli TA271 (1-346/474)
MAKEISSELLN
T
I
L
TR
VGG
P
GNI
A
S
CG
N
C
M
TRLR
L
G
V
H
D
SSLVDPN-
IK
TLE
GV
K
GV
IL
T
SD
Q
V
QVV
F
G
PG
K
AH
R
AAK
A
MSELL
G
EAPV
Q
D
AAEIAAQNKRQLKAKQTSG
VQ
QF
L
AKFAT
IF
T
PLIP
GF
I
AA
GLLLG
IAT
LI
--------
A
T
VMHVPADA
Q
G
T
LPDA
L
N
F
M
KVF
S
K
G
L
F
T
FL
V
I
L
V
GY
N
A
AQA
FGGT
GVN
G
AI
IA
AL
FLLGY
N
P
AATTGYYA
G
FH-----
-
DF
FGL
PI
---D
P
RGN
I
I
G
V
L
IAA
W
A
C
AR
IE
GM
V
RRFM
P
DDLDMLLT
S
L
IT
LLI
TAT
LA
Y
L
I
I
M
P
L
G
G
W
L
FEG
M
S
WLFMH
L
NS--
-
NPFGC
AV
L
A
G
L
F
LIA
V
V
F
GVH
QGFI
P
VY
L
ALM
--
DSQ
G
FNS
L
F
P
I
L
SM
A
GA
G
Q
fig|566546.3.peg.2725
Escherichia coli W (1-346/474)
MAKEISSELLN
T
I
L
TR
VGG
P
GNI
A
S
CG
N
C
M
TRLR
L
G
V
H
D
SSLVDPN-
IK
TLE
GV
K
GV
IL
T
SD
Q
V
QVV
F
G
PG
K
AH
R
AAK
A
MSELL
G
EAPV
Q
D
AAEIAAQNKRQLKAKQTSG
VQ
QF
L
AKFAT
IF
T
PLIP
GF
I
AA
GLLLG
IAT
LI
--------
A
T
VMHVPADA
Q
G
T
LPDA
L
N
F
M
KVF
S
K
G
L
F
T
FL
V
I
L
V
GY
N
A
AQA
FGGT
GVN
G
AI
IA
AL
FLLGY
N
P
AATTGYYA
G
FH-----
-
DF
FGL
PI
---D
P
RGN
I
I
G
V
L
IAA
W
A
C
AR
IE
GM
V
RRFM
P
DDLDMLLT
S
L
IT
LLI
TAT
LA
Y
L
I
I
M
P
L
G
G
W
L
FEG
M
S
WLFMH
L
NS--
-
NPFGC
AV
L
A
G
L
F
LIA
V
V
F
GVH
QGFI
P
VY
L
ALM
--
DSQ
G
FNS
L
F
P
I
L
SM
A
GA
G
Q
fig|566546.4.peg.2629
Escherichia coli W (1-346/474)
MAKEISSELLN
T
I
L
TR
VGG
P
GNI
A
S
CG
N
C
M
TRLR
L
G
V
H
D
SSLVDPN-
IK
TLE
GV
K
GV
IL
T
SD
Q
V
QVV
F
G
PG
K
AH
R
AAK
A
MSELL
G
EAPV
Q
D
AAEIAAQNKRQLKAKQTSG
VQ
QF
L
AKFAT
IF
T
PLIP
GF
I
AA
GLLLG
IAT
LI
--------
A
T
VMHVPADA
Q
G
T
LPDA
L
N
F
M
KVF
S
K
G
L
F
T
FL
V
I
L
V
GY
N
A
AQA
FGGT
GVN
G
AI
IA
AL
FLLGY
N
P
AATTGYYA
G
FH-----
-
DF
FGL
PI
---D
P
RGN
I
I
G
V
L
IAA
W
A
C
AR
IE
GM
V
RRFM
P
DDLDMLLT
S
L
IT
LLI
TAT
LA
Y
L
I
I
M
P
L
G
G
W
L
FEG
M
S
WLFMH
L
NS--
-
NPFGC
AV
L
A
G
L
F
LIA
V
V
F
GVH
QGFI
P
VY
L
ALM
--
DSQ
G
FNS
L
F
P
I
L
SM
A
GA
G
Q
fig|316407.3.peg.2359
Escherichia coli W3110 (1-346/474)
MAKEISSELLN
T
I
L
TR
VGG
P
GNI
A
S
CG
N
C
M
TRLR
L
G
V
H
D
SSLVDPN-
IK
TLE
GV
K
GV
IL
T
SD
Q
V
QVV
F
G
PG
K
AH
R
AAK
A
MSELL
G
EAPV
Q
D
AAEIAAQNKRQLKAKQTSG
VQ
QF
L
AKFAT
IF
T
PLIP
GF
I
AA
GLLLG
IAT
LI
--------
A
T
VMHVPADA
Q
G
T
LPDA
L
N
F
M
KVF
S
K
G
L
F
T
FL
V
I
L
V
GY
N
A
AQA
FGGT
GVN
G
AI
IA
AL
FLLGY
N
P
AATTGYYA
G
FH-----
-
DF
FGL
PI
---D
P
RGN
I
I
G
V
L
IAA
W
A
C
AR
IE
GM
V
RRFM
P
DDLDMLLT
S
L
IT
LLI
TAT
LA
Y
L
I
I
M
P
L
G
G
W
L
FEG
M
S
WLFMH
L
NS--
-
NPFGC
AV
L
A
G
L
F
LIA
V
V
F
GVH
QGFI
P
VY
L
ALM
--
DSQ
G
FNS
L
F
P
I
L
SM
A
GA
G
Q
fig|316385.7.peg.2615
Escherichia coli str. K-12 substr. DH10B (1-346/474)
MAKEISSELLN
T
I
L
TR
VGG
P
GNI
A
S
CG
N
C
M
TRLR
L
G
V
H
D
SSLVDPN-
IK
TLE
GV
K
GV
IL
T
SD
Q
V
QVV
F
G
PG
K
AH
R
AAK
A
MSELL
G
EAPV
Q
D
AAEIAAQNKRQLKAKQTSG
VQ
QF
L
AKFAT
IF
T
PLIP
GF
I
AA
GLLLG
IAT
LI
--------
A
T
VMHVPADA
Q
G
T
LPDA
L
N
F
M
KVF
S
K
G
L
F
T
FL
V
I
L
V
GY
N
A
AQA
FGGT
GVN
G
AI
IA
AL
FLLGY
N
P
AATTGYYA
G
FH-----
-
DF
FGL
PI
---D
P
RGN
I
I
G
V
L
IAA
W
A
C
AR
IE
GM
V
RRFM
P
DDLDMLLT
S
L
IT
LLI
TAT
LA
Y
L
I
I
M
P
L
G
G
W
L
FEG
M
S
WLFMH
L
NS--
-
NPFGC
AV
L
A
G
L
F
LIA
V
V
F
GVH
QGFI
P
VY
L
ALM
--
DSQ
G
FNS
L
F
P
I
L
SM
A
GA
G
Q
fig|511145.12.peg.2524
Escherichia coli str. K-12 substr. MG1655 (1-346/474)
MAKEISSELLN
T
I
L
TR
VGG
P
GNI
A
S
CG
N
C
M
TRLR
L
G
V
H
D
SSLVDPN-
IK
TLE
GV
K
GV
IL
T
SD
Q
V
QVV
F
G
PG
K
AH
R
AAK
A
MSELL
G
EAPV
Q
D
AAEIAAQNKRQLKAKQTSG
VQ
QF
L
AKFAT
IF
T
PLIP
GF
I
AA
GLLLG
IAT
LI
--------
A
T
VMHVPADA
Q
G
T
LPDA
L
N
F
M
KVF
S
K
G
L
F
T
FL
V
I
L
V
GY
N
A
AQA
FGGT
GVN
G
AI
IA
AL
FLLGY
N
P
AATTGYYA
G
FH-----
-
DF
FGL
PI
---D
P
RGN
I
I
G
V
L
IAA
W
A
C
AR
IE
GM
V
RRFM
P
DDLDMLLT
S
L
IT
LLI
TAT
LA
Y
L
I
I
M
P
L
G
G
W
L
FEG
M
S
WLFMH
L
NS--
-
NPFGC
AV
L
A
G
L
F
LIA
V
V
F
GVH
QGFI
P
VY
L
ALM
--
DSQ
G
FNS
L
F
P
I
L
SM
A
GA
G
Q
fig|511145.6.peg.2509
Escherichia coli str. K-12 substr. MG1655 (1-346/474)
MAKEISSELLN
T
I
L
TR
VGG
P
GNI
A
S
CG
N
C
M
TRLR
L
G
V
H
D
SSLVDPN-
IK
TLE
GV
K
GV
IL
T
SD
Q
V
QVV
F
G
PG
K
AH
R
AAK
A
MSELL
G
EAPV
Q
D
AAEIAAQNKRQLKAKQTSG
VQ
QF
L
AKFAT
IF
T
PLIP
GF
I
AA
GLLLG
IAT
LI
--------
A
T
VMHVPADA
Q
G
T
LPDA
L
N
F
M
KVF
S
K
G
L
F
T
FL
V
I
L
V
GY
N
A
AQA
FGGT
GVN
G
AI
IA
AL
FLLGY
N
P
AATTGYYA
G
FH-----
-
DF
FGL
PI
---D
P
RGN
I
I
G
V
L
IAA
W
A
C
AR
IE
GM
V
RRFM
P
DDLDMLLT
S
L
IT
LLI
TAT
LA
Y
L
I
I
M
P
L
G
G
W
L
FEG
M
S
WLFMH
L
NS--
-
NPFGC
AV
L
A
G
L
F
LIA
V
V
F
GVH
QGFI
P
VY
L
ALM
--
DSQ
G
FNS
L
F
P
I
L
SM
A
GA
G
Q
fig|656417.3.peg.4608
Escherichia coli M605 (12-336/624)
VGG
A
D
NI
V
S
LM
HC
A
TRLRF
K
L
K
D
ESKAQAEV
L
K
KTP
G
I
I
M
V
VE
S
GG
Q
F
QVVIG
NH
V
AD
-
VFL
A
VNSVA
G
LGE-
-
-
KAQQAPENDDKGNLLN---
--
RF
V
YVISG
IF
T
PLI
G
LM
A
AT
G
I
L
K
G
MLA
L
A
--------
L
T
FQWTTEQ-
S
G
T
----
Y
L
I
L
FSA
S
D
A
L
F
W
F
F
PI
I
L
GY
T
A
GKR
F
S
G
N
PFT
A
MV
I
G
GA
LV
---
HP
LILTAFEN
G
QKVDALG
L
DF
LGI
P
V
TLLN
Y
SSS
VIP
I
I
FSA
W
L
C
SI
L
E
RR
L
NAWL
P
SAIKNFFT
PL
LC
L
MV
ITP
I
T
F
LL
V
GP
L
S
T
WI
SEL
I
A
AGYLW
L
YQAV
-
PAFAG
AV
M
G
G
F
W
QIF
VM
F
G
L
H
WGLI
P
LI
I
NNF
--
TVL
G
YDT
M
I
PLL
MP
A
IM
AQ
fig|431946.3.peg.3716
Escherichia coli SE15 (12-336/624)
VGG
A
D
NI
V
S
LM
HC
A
TRLRF
K
L
K
D
ESKAQAEV
L
K
KTP
G
I
I
M
V
VE
S
GG
Q
F
QVVIG
NH
V
AD
-
VFL
A
VNSVA
G
LGE-
-
-
KAQQAPENDDKGNLLN---
--
RF
V
YVISG
IF
T
PLI
G
LM
A
AT
G
I
L
K
G
MLA
L
A
--------
L
T
FQWTTEQ-
S
G
T
----
Y
L
I
L
FSA
S
D
A
L
F
W
F
F
PI
I
L
GY
T
A
GKR
F
S
G
N
PFT
A
MV
I
G
GA
LV
---
HP
LILTAFEN
G
QKVDALG
L
DF
LGI
P
V
TLLN
Y
SSS
VIP
I
I
FSA
W
L
C
SI
L
E
RR
L
NAWL
P
SAIKNFFT
PL
LC
L
MV
ITP
I
T
F
LL
V
GP
L
S
T
WI
SEL
I
A
AGYLW
L
YQAV
-
PAFAG
AV
M
G
G
F
W
QIF
VM
F
G
L
H
WGLI
P
LI
I
NNF
--
TVL
G
YDT
M
I
PLL
MP
A
IM
AQ
fig|679205.4.peg.4388
Escherichia coli MS 124-1 (7-336/625)
K
I
V
AG
VGG
A
D
NI
V
S
LM
HC
A
TRLRF
K
L
K
D
ESKAQAEV
L
K
KTP
G
I
I
M
V
VE
S
GG
Q
F
QVVIG
NH
V
AD
-
VFL
A
VNSVA
G
LDE-
-
-
KAQQAPENDDKGNLLN---
--
RF
V
YVISG
IF
T
PLI
G
LM
A
AT
G
I
L
K
G
MLA
L
A
--------
L
T
FQWTTEQ-
S
G
T
----
Y
L
I
L
FSA
S
D
A
L
F
W
F
F
PI
I
L
GY
T
A
GKR
FGG
N
PFT
A
MV
I
G
GA
LV
---
HP
LILTAFEN
G
QKADALG
L
DF
LGI
P
V
TLLN
Y
SSS
VIP
I
I
FSA
W
L
C
SI
L
E
RR
L
NAWL
P
SAIKNFFT
PL
LC
L
MV
ITP
VT
F
LL
V
GP
L
S
T
WI
SEL
I
A
AGYLW
L
YQAV
-
PVFAG
AV
M
G
G
F
W
QIF
VM
F
G
L
H
WGLV
P
LC
I
NNF
--
TVL
G
YDT
M
I
PLL
MP
A
IM
AQ
fig|749533.3.peg.1076
Escherichia coli MS 84-1 (7-336/625)
K
I
V
AG
VGG
A
D
NI
V
S
LM
HC
A
TRLRF
K
L
K
D
ESKAQAEV
L
K
KTP
G
I
I
M
V
VE
S
GG
Q
F
QVVIG
NH
V
AD
-
VFL
A
VNSVA
G
LDE-
-
-
KAQQAPENDDKGNLLN---
--
RF
V
YVISG
IF
T
PLI
G
LM
A
AT
G
I
L
K
G
MLA
L
A
--------
L
T
FQWTTEQ-
S
G
T
----
Y
L
I
L
FSA
S
D
A
L
F
W
F
F
PI
I
L
GY
T
A
GKR
FGG
N
PFT
A
MV
I
G
GA
LV
---
HP
LILTAFEN
G
QKADALG
L
DF
LGI
P
V
TLLN
Y
SSS
VIP
I
I
FSA
W
L
C
SI
L
E
RR
L
NAWL
P
SAIKNFFT
PL
LC
L
MV
ITP
VT
F
LL
V
GP
L
S
T
WI
SEL
I
A
AGYLW
L
YQAV
-
PVFAG
AV
M
G
G
F
W
QIF
VM
F
G
L
H
WGLV
P
LC
I
NNF
--
TVL
G
YDT
M
I
PLL
MP
A
IM
AQ
fig|331111.12.peg.3273
Escherichia coli E24377A (12-325/485)
V
I
AA
L
GG
V
D
NI
S
A
VT
HC
M
TRLRF
V
I
K
D
DQLIDSPT
L
K
TIP
GV
L
GV
VR
S
DN
Q
C
QV
I
IG
NT
V
SQ
-
---
A
FQEVV
S
LLPG
-
D
MQPVQPVGKPKLTLRRIGA
--
GI
L
DALIS
TM
S
PLIP
AI
I
GG
S
MV
K
-
LLA
M
I
--------
L
E
MSGVLTKG
S
P
T
----
L
T
I
L
NVI
GDG
A
F
F
FLP
L
M
V
AA
SA
AIK
F
KTN
MSL
A
IA
IA
GV
LV
---
HP
SFIELMAK
A
AQGEHV-
-
E
F
ALI
P
V
TAVK
Y
TYT
VIP
A
L
VMT
W
C
L
SY
IE
RW
V
DRIT
P
AVTKNFLK
P
M
LI
V
LI
AAP
LA
I
LLIGP
I
G
I
WI
GSA
IS
ALVYT
I
HGYL
-
GWLSV
A
I
M
G
A
LW
PLL
VMTG
M
H
RVFT
P
TI
I
QTI
--
AET
G
fig|331111.3.peg.715
Escherichia coli E24377A (12-325/485)
V
I
AA
L
GG
V
D
NI
S
A
VT
HC
M
TRLRF
V
I
K
D
DQLIDSPT
L
K
TIP
GV
L
GV
VR
S
DN
Q
C
QV
I
IG
NT
V
SQ
-
---
A
FQEVV
S
LLPG
-
D
MQPVQPVGKPKLTLRRIGA
--
GI
L
DALIS
TM
S
PLIP
AI
I
GG
S
MV
K
-
LLA
M
I
--------
L
E
MSGVLTKG
S
P
T
----
L
T
I
L
NVI
GDG
A
F
F
FLP
L
M
V
AA
SA
AIK
F
KTN
MSL
A
IA
IA
GV
LV
---
HP
SFIELMAK
A
AQGEHV-
-
E
F
ALI
P
V
TAVK
Y
TYT
VIP
A
L
VMT
W
C
L
SY
IE
RW
V
DRIT
P
AVTKNFLK
P
M
LI
V
LI
AAP
LA
I
LLIGP
I
G
I
WI
GSA
IS
ALVYT
I
HGYL
-
GWLSV
A
I
M
G
A
LW
PLL
VMTG
M
H
RVFT
P
TI
I
QTI
--
AET
G
fig|562.375.peg.1039
Escherichia coli EC4100B (12-325/485)
V
I
AA
L
GG
V
D
NI
S
A
VT
HC
M
TRLRF
V
I
K
D
DQLIDSPT
L
K
TIP
GV
L
GV
VR
S
DN
Q
C
QV
I
IG
NT
V
SQ
-
---
A
FQEVV
S
LLPG
-
D
MQPVQPVGKPKLTLRRIGA
--
GI
L
DALIS
TM
S
PLIP
AI
I
GG
S
MV
K
-
LLA
M
I
--------
L
E
MSGVLTKG
S
P
T
----
L
T
I
L
NVI
GDG
A
F
F
FLP
L
M
V
AA
SA
AIK
F
KTN
MSL
A
IA
IA
GV
LV
---
HP
SFIELMAK
A
AQGEHV-
-
E
F
ALI
P
V
TAVK
Y
TYT
VIP
A
L
VMT
W
C
L
SY
IE
RW
V
DRIT
P
AVTKNFLK
P
M
LI
V
LI
AAP
LA
I
LLIGP
I
G
I
WI
GSA
IS
ALVYT
I
HGYL
-
GWLSV
A
I
M
G
A
LW
PLL
VMTG
M
H
RVFT
P
TI
I
QTI
--
AET
G
fig|749545.3.peg.2280
Escherichia coli MS 182-1 (12-325/485)
V
I
AA
L
GG
V
D
NI
S
A
VT
HC
M
TRLRF
V
I
K
D
DQLIDSPT
L
K
TIP
GV
L
GV
VR
S
DN
Q
C
QV
I
IG
NT
V
SQ
-
---
A
FQEVV
S
LLPG
-
D
MQPVQPVGKPKLTLRRIGA
--
GI
L
DALIS
TM
S
PLIP
AI
I
GG
S
MV
K
-
LLA
M
I
--------
L
E
MSGVLTKG
S
P
T
----
L
T
I
L
NVI
GDG
A
F
F
FLP
L
M
V
AA
SA
AIK
F
KTN
MSL
A
IA
IA
GV
LV
---
HP
SFIELMAK
A
AQGEHV-
-
E
F
ALI
P
V
TAVK
Y
TYT
VIP
A
L
VMT
W
C
L
SY
IE
RW
V
DRIT
P
AVTKNFLK
P
M
LI
V
LI
AAP
LA
I
LLIGP
I
G
I
WI
GSA
IS
ALVYT
I
HGYL
-
GWLSV
A
I
M
G
A
LW
PLL
VMTG
M
H
RVFT
P
TI
I
QTI
--
AET
G
fig|749532.3.peg.1181
Escherichia coli MS 78-1 (12-325/485)
V
I
AA
L
GG
V
D
NI
S
A
VT
HC
M
TRLRF
V
I
K
D
DQLIDSPT
L
K
TIP
GV
L
GV
VR
S
DN
Q
C
QV
I
IG
NT
V
SQ
-
---
A
FQEVV
S
LLPG
-
D
MQPVQPVGKPKLTLRRIGA
--
GI
L
DALIS
TM
S
PLIP
AI
I
GG
S
MV
K
-
LLA
M
I
--------
L
E
MSGVLTKG
S
P
T
----
L
T
I
L
NVI
GDG
A
F
F
FLP
L
M
V
AA
SA
AIK
F
KTN
MSL
A
IA
IA
GV
LV
---
HP
SFIELMAK
A
AQGEHV-
-
E
F
ALI
P
V
TAVK
Y
TYT
VIP
A
L
VMT
W
C
L
SY
IE
RW
V
DRIT
P
AVTKNFLK
P
M
LI
V
LI
AAP
LA
I
LLIGP
I
G
I
WI
GSA
IS
ALVYT
I
HGYL
-
GWLSV
A
I
M
G
A
LW
PLL
VMTG
M
H
RVFT
P
TI
I
QTI
--
AET
G
fig|1040638.4.peg.2578
Escherichia coli O104:H4 str. LB226692 (12-325/485)
V
I
AA
L
GG
V
D
NI
S
A
VT
HC
M
TRLRF
V
I
K
D
DQLIDSPT
L
K
TIP
GV
L
GV
VR
S
DN
Q
C
QV
I
IG
NT
V
SQ
-
---
A
FQEVV
S
LLPG
-
D
MQPAQPVGKPKLTLRRIGA
--
GI
L
DALIG
TM
S
PLIP
AI
I
GG
S
MV
K
-
LLA
M
I
--------
L
E
MSGVLTKG
S
P
T
----
L
T
I
L
NVI
GDG
A
F
F
FLP
L
M
V
AA
SA
AIK
F
KTN
MSL
A
IA
IA
GV
LV
---
HP
SFIELMAK
A
AQGEHV-
-
E
F
ALI
P
V
TAVK
Y
TYT
VIP
A
L
VMT
W
C
L
SY
IE
RW
V
DRIT
P
AVTKNFLK
P
M
LI
V
LI
AAP
LA
I
LLIGP
I
G
I
WI
GSA
IS
ALVYT
I
HGYL
-
GWLSV
A
I
M
G
A
LW
PLL
VMTG
M
H
RVFT
P
TI
I
QTI
--
AET
G
fig|6666666.5357.peg.4362
Escherichia coli TY-2482 (12-325/485)
V
I
AA
L
GG
V
D
NI
S
A
VT
HC
M
TRLRF
V
I
K
D
DQLIDSPT
L
K
TIP
GV
L
GV
VR
S
DN
Q
C
QV
I
IG
NT
V
SQ
-
---
A
FQEVV
S
LLPG
-
D
MQPAQPVGKPKLTLRRIGA
--
GI
L
DALIG
TM
S
PLIP
AI
I
GG
S
MV
K
-
LLA
M
I
--------
L
E
MSGVLTKG
S
P
T
----
L
T
I
L
NVI
GDG
A
F
F
FLP
L
M
V
AA
SA
AIK
F
KTN
MSL
A
IA
IA
GV
LV
---
HP
SFIELMAK
A
AQGEHV-
-
E
F
ALI
P
V
TAVK
Y
TYT
VIP
A
L
VMT
W
C
L
SY
IE
RW
V
DRIT
P
AVTKNFLK
P
M
LI
V
LI
AAP
LA
I
LLIGP
I
G
I
WI
GSA
IS
ALVYT
I
HGYL
-
GWLSV
A
I
M
G
A
LW
PLL
VMTG
M
H
RVFT
P
TI
I
QTI
--
AET
G
fig|585055.6.peg.3011
Escherichia coli 55989 (12-325/485)
V
I
AA
L
GG
V
D
NI
S
A
VT
HC
M
TRLRF
V
I
K
D
DQLIDSPT
L
K
TIP
GV
L
GV
VR
S
DN
Q
C
QV
I
IG
NT
V
SQ
-
---
A
FQEVV
S
LLPG
-
D
MQPAQPVGKPKLTLRRIGA
--
GI
L
DALIG
TM
S
PLIP
AI
I
GG
S
MV
K
-
LLA
M
I
--------
L
E
MSGVLTKG
S
P
T
----
L
T
I
L
NVI
GDG
A
F
F
FLP
L
M
V
AA
SA
AIK
F
KTN
MSL
A
IA
IA
GV
LV
---
HP
SFIELMAK
A
AQGEHV-
-
E
F
ALI
P
V
TAVK
Y
TYT
VIP
A
L
VMT
W
C
L
SY
IE
RW
V
DRIT
P
AVTKNFLK
P
M
LI
V
LI
AAP
LA
I
LLIGP
I
G
I
WI
GSA
IS
ALVYT
I
HGYL
-
GWLSV
A
I
M
G
A
LW
PLL
VMTG
M
H
RVFT
P
TI
I
QTI
--
AET
G
fig|585055.8.peg.3015
Escherichia coli 55989 (12-325/485)
V
I
AA
L
GG
V
D
NI
S
A
VT
HC
M
TRLRF
V
I
K
D
DQLIDSPT
L
K
TIP
GV
L
GV
VR
S
DN
Q
C
QV
I
IG
NT
V
SQ
-
---
A
FQEVV
S
LLPG
-
D
MQPAQPVGKPKLTLRRIGA
--
GI
L
DALIG
TM
S
PLIP
AI
I
GG
S
MV
K
-
LLA
M
I
--------
L
E
MSGVLTKG
S
P
T
----
L
T
I
L
NVI
GDG
A
F
F
FLP
L
M
V
AA
SA
AIK
F
KTN
MSL
A
IA
IA
GV
LV
---
HP
SFIELMAK
A
AQGEHV-
-
E
F
ALI
P
V
TAVK
Y
TYT
VIP
A
L
VMT
W
C
L
SY
IE
RW
V
DRIT
P
AVTKNFLK
P
M
LI
V
LI
AAP
LA
I
LLIGP
I
G
I
WI
GSA
IS
ALVYT
I
HGYL
-
GWLSV
A
I
M
G
A
LW
PLL
VMTG
M
H
RVFT
P
TI
I
QTI
--
AET
G
fig|340184.3.peg.1904
Escherichia coli B7A (12-325/485)
V
I
AA
L
GG
V
D
NI
S
A
VT
HC
M
TRLRF
V
I
K
D
DQLIDSPT
L
K
TIP
GV
L
GV
VR
S
DN
Q
C
QV
I
IG
NT
V
SQ
-
---
A
FQEVV
S
LLPG
-
D
MQPAQPVGKPKLTLRRIGA
--
GI
L
DALIG
TM
S
PLIP
AI
I
GG
S
MV
K
-
LLA
M
I
--------
L
E
MSGVLTKG
S
P
T
----
L
T
I
L
NVI
GDG
A
F
F
FLP
L
M
V
AA
SA
AIK
F
KTN
MSL
A
IA
IA
GV
LV
---
HP
SFIELMAK
A
AQGEHV-
-
E
F
ALI
P
V
TAVK
Y
TYT
VIP
A
L
VMT
W
C
L
SY
IE
RW
V
DRIT
P
AVTKNFLK
P
M
LI
V
LI
AAP
LA
I
LLIGP
I
G
I
WI
GSA
IS
ALVYT
I
HGYL
-
GWLSV
A
I
M
G
A
LW
PLL
VMTG
M
H
RVFT
P
TI
I
QTI
--
AET
G
fig|340184.6.peg.1994
Escherichia coli B7A (12-325/485)
V
I
AA
L
GG
V
D
NI
S
A
VT
HC
M
TRLRF
V
I
K
D
DQLIDSPT
L
K
TIP
GV
L
GV
VR
S
DN
Q
C
QV
I
IG
NT
V
SQ
-
---
A
FQEVV
S
LLPG
-
D
MQPAQPVGKPKLTLRRIGA
--
GI
L
DALIG
TM
S
PLIP
AI
I
GG
S
MV
K
-
LLA
M
I
--------
L
E
MSGVLTKG
S
P
T
----
L
T
I
L
NVI
GDG
A
F
F
FLP
L
M
V
AA
SA
AIK
F
KTN
MSL
A
IA
IA
GV
LV
---
HP
SFIELMAK
A
AQGEHV-
-
E
F
ALI
P
V
TAVK
Y
TYT
VIP
A
L
VMT
W
C
L
SY
IE
RW
V
DRIT
P
AVTKNFLK
P
M
LI
V
LI
AAP
LA
I
LLIGP
I
G
I
WI
GSA
IS
ALVYT
I
HGYL
-
GWLSV
A
I
M
G
A
LW
PLL
VMTG
M
H
RVFT
P
TI
I
QTI
--
AET
G
fig|585034.4.peg.2754
Escherichia coli IAI1 (12-325/485)
V
I
AA
L
GG
V
D
NI
S
A
VT
HC
M
TRLRF
V
I
K
D
DQLIDSPT
L
K
TIP
GV
L
GV
VR
S
DN
Q
C
QV
I
IG
NT
V
SQ
-
---
A
FQEVV
S
LLPG
-
D
MQPAQPVGKPKLTLRRIGA
--
GI
L
DALIG
TM
S
PLIP
AI
I
GG
S
MV
K
-
LLA
M
I
--------
L
E
MSGVLTKG
S
P
T
----
L
T
I
L
NVI
GDG
A
F
F
FLP
L
M
V
AA
SA
AIK
F
KTN
MSL
A
IA
IA
GV
LV
---
HP
SFIELMAK
A
AQGEHV-
-
E
F
ALI
P
V
TAVK
Y
TYT
VIP
A
L
VMT
W
C
L
SY
IE
RW
V
DRIT
P
AVTKNFLK
P
M
LI
V
LI
AAP
LA
I
LLIGP
I
G
I
WI
GSA
IS
ALVYT
I
HGYL
-
GWLSV
A
I
M
G
A
LW
PLL
VMTG
M
H
RVFT
P
TI
I
QTI
--
AET
G
fig|585034.5.peg.2753
Escherichia coli IAI1 (12-325/485)
V
I
AA
L
GG
V
D
NI
S
A
VT
HC
M
TRLRF
V
I
K
D
DQLIDSPT
L
K
TIP
GV
L
GV
VR
S
DN
Q
C
QV
I
IG
NT
V
SQ
-
---
A
FQEVV
S
LLPG
-
D
MQPAQPVGKPKLTLRRIGA
--
GI
L
DALIG
TM
S
PLIP
AI
I
GG
S
MV
K
-
LLA
M
I
--------
L
E
MSGVLTKG
S
P
T
----
L
T
I
L
NVI
GDG
A
F
F
FLP
L
M
V
AA
SA
AIK
F
KTN
MSL
A
IA
IA
GV
LV
---
HP
SFIELMAK
A
AQGEHV-
-
E
F
ALI
P
V
TAVK
Y
TYT
VIP
A
L
VMT
W
C
L
SY
IE
RW
V
DRIT
P
AVTKNFLK
P
M
LI
V
LI
AAP
LA
I
LLIGP
I
G
I
WI
GSA
IS
ALVYT
I
HGYL
-
GWLSV
A
I
M
G
A
LW
PLL
VMTG
M
H
RVFT
P
TI
I
QTI
--
AET
G
fig|679207.4.peg.889
Escherichia coli MS 107-1 (12-325/485)
V
I
AA
L
GG
V
D
NI
S
A
VT
HC
M
TRLRF
V
I
K
D
DQLIDSPT
L
K
TIP
GV
L
GV
VR
S
DN
Q
C
QV
I
IG
NT
V
SQ
-
---
A
FQEVV
S
LLPG
-
D
MQPAQPVGKPKLTLRRIGA
--
GI
L
DALIG
TM
S
PLIP
AI
I
GG
S
MV
K
-
LLA
M
I
--------
L
E
MSGVLTKG
S
P
T
----
L
T
I
L
NVI
GDG
A
F
F
FLP
L
M
V
AA
SA
AIK
F
KTN
MSL
A
IA
IA
GV
LV
---
HP
SFIELMAK
A
AQGEHV-
-
E
F
ALI
P
V
TAVK
Y
TYT
VIP
A
L
VMT
W
C
L
SY
IE
RW
V
DRIT
P
AVTKNFLK
P
M
LI
V
LI
AAP
LA
I
LLIGP
I
G
I
WI
GSA
IS
ALVYT
I
HGYL
-
GWLSV
A
I
M
G
A
LW
PLL
VMTG
M
H
RVFT
P
TI
I
QTI
--
AET
G
fig|679206.4.peg.279
Escherichia coli MS 119-7 (12-325/485)
V
I
AA
L
GG
V
D
NI
S
A
VT
HC
M
TRLRF
V
I
K
D
DQLIDSPT
L
K
TIP
GV
L
GV
VR
S
DN
Q
C
QV
I
IG
NT
V
SQ
-
---
A
FQEVV
S
LLPG
-
D
MQPAQPVGKPKLTLRRIGA
--
GI
L
DALIG
TM
S
PLIP
AI
I
GG
S
MV
K
-
LLA
M
I
--------
L
E
MSGVLTKG
S
P
T
----
L
T
I
L
NVI
GDG
A
F
F
FLP
L
M
V
AA
SA
AIK
F
KTN
MSL
A
IA
IA
GV
LV
---
HP
SFIELMAK
A
AQGEHV-
-
E
F
ALI
P
V
TAVK
Y
TYT
VIP
A
L
VMT
W
C
L
SY
IE
RW
V
DRIT
P
AVTKNFLK
P
M
LI
V
LI
AAP
LA
I
LLIGP
I
G
I
WI
GSA
IS
ALVYT
I
HGYL
-
GWLSV
A
I
M
G
A
LW
PLL
VMTG
M
H
RVFT
P
TI
I
QTI
--
AET
G
fig|679204.3.peg.2311
Escherichia coli MS 145-7 (12-325/485)
V
I
AA
L
GG
V
D
NI
S
A
VT
HC
M
TRLRF
V
I
K
D
DQLIDSPT
L
K
TIP
GV
L
GV
VR
S
DN
Q
C
QV
I
IG
NT
V
SQ
-
---
A
FQEVV
S
LLPG
-
D
MQPAQPVGKPKLTLRRIGA
--
GI
L
DALIG
TM
S
PLIP
AI
I
GG
S
MV
K
-
LLA
M
I
--------
L
E
MSGVLTKG
S
P
T
----
L
T
I
L
NVI
GDG
A
F
F
FLP
L
M
V
AA
SA
AIK
F
KTN
MSL
A
IA
IA
GV
LV
---
HP
SFIELMAK
A
AQGEHV-
-
E
F
ALI
P
V
TAVK
Y
TYT
VIP
A
L
VMT
W
C
L
SY
IE
RW
V
DRIT
P
AVTKNFLK
P
M
LI
V
LI
AAP
LA
I
LLIGP
I
G
I
WI
GSA
IS
ALVYT
I
HGYL
-
GWLSV
A
I
M
G
A
LW
PLL
VMTG
M
H
RVFT
P
TI
I
QTI
--
AET
G
fig|585396.4.peg.3543
Escherichia coli O111:H- str. 11128 (12-325/485)
V
I
AA
L
GG
V
D
NI
S
A
VT
HC
M
TRLRF
V
I
K
D
DQLIDSPT
L
K
TIP
GV
L
GV
VR
S
DN
Q
C
QV
I
IG
NT
V
SQ
-
---
A
FQEVV
S
LLPG
-
D
MQPAQPVGKPKLTLRRIGA
--
GI
L
DALIG
TM
S
PLIP
AI
I
GG
S
MV
K
-
LLA
M
I
--------
L
E
MSGVLTKG
S
P
T
----
L
T
I
L
NVI
GDG
A
F
F
FLP
L
M
V
AA
SA
AIK
F
KTN
MSL
A
IA
IA
GV
LV
---
HP
SFIELMAK
A
AQGEHV-
-
E
F
ALI
P
V
TAVK
Y
TYT
VIP
A
L
VMT
W
C
L
SY
IE
RW
V
DRIT
P
AVTKNFLK
P
M
LI
V
LI
AAP
LA
I
LLIGP
I
G
I
WI
GSA
IS
ALVYT
I
HGYL
-
GWLSV
A
I
M
G
A
LW
PLL
VMTG
M
H
RVFT
P
TI
I
QTI
--
AET
G
fig|573235.3.peg.3854
Escherichia coli O26:H11 str. 11368 (12-325/485)
V
I
AA
L
GG
V
D
NI
S
A
VT
HC
M
TRLRF
V
I
K
D
DQLIDSPT
L
K
TIP
GV
L
GV
VR
S
DN
Q
C
QV
I
IG
NT
V
SQ
-
---
A
FQEVV
S
LLPG
-
D
MQPAQPVGKPKLTLRRIGA
--
GI
L
DALIG
TM
S
PLIP
AI
I
GG
S
MV
K
-
LLA
M
I
--------
L
E
MSGVLTKG
S
P
T
----
L
T
I
L
NVI
GDG
A
F
F
FLP
L
M
V
AA
SA
AIK
F
KTN
MSL
A
IA
IA
GV
LV
---
HP
SFIELMAK
A
AQGEHV-
-
E
F
ALI
P
V
TAVK
Y
TYT
VIP
A
L
VMT
W
C
L
SY
IE
RW
V
DRIT
P
AVTKNFLK
P
M
LI
V
LI
AAP
LA
I
LLIGP
I
G
I
WI
GSA
IS
ALVYT
I
HGYL
-
GWLSV
A
I
M
G
A
LW
PLL
VMTG
M
H
RVFT
P
TI
I
QTI
--
AET
G
fig|409438.11.peg.3131
Escherichia coli SE11 (12-325/485)
V
I
AA
L
GG
V
D
NI
S
A
VT
HC
M
TRLRF
V
I
K
D
DQLIDSPT
L
K
TIP
GV
L
GV
VR
S
DN
Q
C
QV
I
IG
NT
V
SQ
-
---
A
FQEVV
S
LLPG
-
D
MQPAQPVGKPKLTLRRIGA
--
GI
L
DALIG
TM
S
PLIP
AI
I
GG
S
MV
K
-
LLA
M
I
--------
L
E
MSGVLTKG
S
P
T
----
L
T
I
L
NVI
GDG
A
F
F
FLP
L
M
V
AA
SA
AIK
F
KTN
MSL
A
IA
IA
GV
LV
---
HP
SFIELMAK
A
AQGEHV-
-
E
F
ALI
P
V
TAVK
Y
TYT
VIP
A
L
VMT
W
C
L
SY
IE
RW
V
DRIT
P
AVTKNFLK
P
M
LI
V
LI
AAP
LA
I
LLIGP
I
G
I
WI
GSA
IS
ALVYT
I
HGYL
-
GWLSV
A
I
M
G
A
LW
PLL
VMTG
M
H
RVFT
P
TI
I
QTI
--
AET
G
fig|656443.3.peg.3468
Escherichia coli TA271 (12-325/485)
V
I
AA
L
GG
V
D
NI
S
A
VT
HC
M
TRLRF
V
I
K
D
DQLIDSPT
L
K
TIP
GV
L
GV
VR
S
DN
Q
C
QV
I
IG
NT
V
SQ
-
---
A
FQEVV
S
LLPG
-
D
MQPAQPVGKPKLTLRRIGA
--
GI
L
DALIG
TM
S
PLIP
AI
I
GG
S
MV
K
-
LLA
M
I
--------
L
E
MSGVLTKG
S
P
T
----
L
T
I
L
NVI
GDG
A
F
F
FLP
L
M
V
AA
SA
AIK
F
KTN
MSL
A
IA
IA
GV
LV
---
HP
SFIELMAK
A
AQGEHV-
-
E
F
ALI
P
V
TAVK
Y
TYT
VIP
A
L
VMT
W
C
L
SY
IE
RW
V
DRIT
P
AVTKNFLK
P
M
LI
V
LI
AAP
LA
I
LLIGP
I
G
I
WI
GSA
IS
ALVYT
I
HGYL
-
GWLSV
A
I
M
G
A
LW
PLL
VMTG
M
H
RVFT
P
TI
I
QTI
--
AET
G
fig|656419.3.peg.3531
Escherichia coli M718 (12-325/485)
V
I
AA
L
GG
V
D
NI
S
A
VT
HC
M
TRLRF
V
I
K
D
DALIDSPT
L
K
TIP
GV
L
GV
VR
S
DN
Q
C
QV
I
IG
NT
V
SQ
-
---
A
FQEVV
S
LLPG
-
D
MQPALPVGKPKLTLRRIGA
--
GI
L
DALIG
TM
S
PLIP
AI
I
GG
S
MV
K
-
LLA
M
I
--------
L
E
MSGVLTKG
S
P
T
----
L
T
I
L
NVI
GDG
A
F
F
FLP
L
M
V
AA
SA
AIK
F
KTN
MSL
A
IA
IA
GV
LV
---
HP
SFIELMAK
A
AQGEHV-
-
E
F
ALI
P
V
TAVK
Y
TYT
VIP
A
L
VMT
W
C
L
SY
IE
RW
V
DRIT
P
AVTKNFLK
P
M
LI
V
LI
AAP
LA
I
LLIGP
I
G
I
WI
GSA
IS
ALVYT
I
HGYL
-
GWLSV
A
I
M
G
A
LW
PLL
VMTG
M
H
RVFT
P
TI
I
QTI
--
AET
G
fig|749537.3.peg.2836
Escherichia coli MS 115-1 (12-325/485)
V
I
AA
L
GG
V
D
NI
S
A
VT
HC
M
TRLRF
V
I
K
D
DQLIDSPT
L
K
TIP
GV
L
GV
VR
S
DN
Q
C
QV
I
IG
NT
V
SQ
-
---
T
FQEVV
S
LLPG
-
D
MQPAQPVGKPKLTLRRIGA
--
GI
L
DALIG
TM
S
PLIP
AI
I
GG
S
MV
K
-
LLA
M
I
--------
L
E
MSGVLTKG
S
P
T
----
L
T
I
L
NVI
GDG
A
F
F
FLP
L
M
V
AA
SA
AIK
F
KTN
MSL
A
IA
IA
GV
LV
---
HP
SFIELMAK
A
AQGEHV-
-
E
F
ALI
P
V
TAVK
Y
TYT
VIP
A
L
VMT
W
C
L
SY
IE
RW
V
DRIT
P
AVTKNFLK
P
M
LI
V
LI
AAP
LA
I
LLIGP
I
G
I
WI
GSA
IS
ALVYT
I
HGYL
-
GWLSV
A
I
M
G
A
LW
PLL
VMTG
M
H
RVFT
P
TI
I
QTI
--
AET
G
fig|562.373.peg.4212
Escherichia coli 1125A (12-325/485)
V
I
AA
L
GG
V
D
NI
S
A
VT
HC
M
TRLRF
V
I
K
D
DALIDSPT
L
K
TIP
GV
L
GV
VR
S
DN
Q
C
QV
I
IG
NT
V
SQ
-
---
A
FQEVV
S
LLPG
-
D
MQPALPVGKPKLTLRRIGA
--
GI
L
DALIG
TM
S
PLIP
AI
I
GG
S
MV
K
-
LLA
M
I
--------
L
E
MSGVLTKG
S
P
T
----
L
T
I
L
NVI
GDG
A
F
F
FLP
L
M
V
AA
SA
AIK
F
KTN
MSL
A
IA
IA
GV
LV
---
HP
SFIELMAK
A
AQGEHV-
-
E
F
ALI
P
V
TAVK
Y
TYT
VIP
A
L
VMT
W
C
L
SY
IE
RW
V
DRIT
P
AVTKNFLK
P
M
LI
V
LI
AAP
LA
I
LLIGP
I
G
I
WI
GSA
IS
ALVYT
I
HGYL
-
GWLSV
A
I
M
G
A
LW
PLL
VMTG
M
H
RVFT
L
TI
I
QTI
--
AET
G
fig|444454.5.peg.2606
Escherichia coli O157:H7 str. EC4024 (12-325/485)
V
I
AA
L
GG
V
D
NI
S
A
VT
HC
M
TRLRF
V
I
K
D
DALIDSPT
L
K
TIP
GV
L
GV
VR
S
DN
Q
C
QV
I
IG
NT
V
SQ
-
---
A
FQEVV
S
LLPG
-
D
MQPALPVGKPKLTLRRIGA
--
GI
L
DALIG
TM
S
PLIP
AI
I
GG
S
MV
K
-
LLA
M
I
--------
L
E
MSGVLTKG
S
P
T
----
L
T
I
L
NVI
GDG
A
F
F
FLP
L
M
V
AA
SA
AIK
F
KTN
MSL
A
IA
IA
GV
LV
---
HP
SFIELMAK
A
AQGEHV-
-
E
F
ALI
P
V
TAVK
Y
TYT
VIP
A
L
VMT
W
C
L
SY
IE
RW
V
DRIT
P
AVTKNFLK
P
M
LI
V
LI
AAP
LA
I
LLIGP
I
G
I
WI
GSA
IS
ALVYT
I
HGYL
-
GWLSV
A
I
M
G
A
LW
PLL
VMTG
M
H
RVFT
L
TI
I
QTI
--
AET
G
fig|444449.5.peg.2069
Escherichia coli O157:H7 str. EC4042 (12-325/485)
V
I
AA
L
GG
V
D
NI
S
A
VT
HC
M
TRLRF
V
I
K
D
DALIDSPT
L
K
TIP
GV
L
GV
VR
S
DN
Q
C
QV
I
IG
NT
V
SQ
-
---
A
FQEVV
S
LLPG
-
D
MQPALPVGKPKLTLRRIGA
--
GI
L
DALIG
TM
S
PLIP
AI
I
GG
S
MV
K
-
LLA
M
I
--------
L
E
MSGVLTKG
S
P
T
----
L
T
I
L
NVI
GDG
A
F
F
FLP
L
M
V
AA
SA
AIK
F
KTN
MSL
A
IA
IA
GV
LV
---
HP
SFIELMAK
A
AQGEHV-
-
E
F
ALI
P
V
TAVK
Y
TYT
VIP
A
L
VMT
W
C
L
SY
IE
RW
V
DRIT
P
AVTKNFLK
P
M
LI
V
LI
AAP
LA
I
LLIGP
I
G
I
WI
GSA
IS
ALVYT
I
HGYL
-
GWLSV
A
I
M
G
A
LW
PLL
VMTG
M
H
RVFT
L
TI
I
QTI
--
AET
G
fig|444448.5.peg.824
Escherichia coli O157:H7 str. EC4045 (12-325/485)
V
I
AA
L
GG
V
D
NI
S
A
VT
HC
M
TRLRF
V
I
K
D
DALIDSPT
L
K
TIP
GV
L
GV
VR
S
DN
Q
C
QV
I
IG
NT
V
SQ
-
---
A
FQEVV
S
LLPG
-
D
MQPALPVGKPKLTLRRIGA
--
GI
L
DALIG
TM
S
PLIP
AI
I
GG
S
MV
K
-
LLA
M
I
--------
L
E
MSGVLTKG
S
P
T
----
L
T
I
L
NVI
GDG
A
F
F
FLP
L
M
V
AA
SA
AIK
F
KTN
MSL
A
IA
IA
GV
LV
---
HP
SFIELMAK
A
AQGEHV-
-
E
F
ALI
P
V
TAVK
Y
TYT
VIP
A
L
VMT
W
C
L
SY
IE
RW
V
DRIT
P
AVTKNFLK
P
M
LI
V
LI
AAP
LA
I
LLIGP
I
G
I
WI
GSA
IS
ALVYT
I
HGYL
-
GWLSV
A
I
M
G
A
LW
PLL
VMTG
M
H
RVFT
L
TI
I
QTI
--
AET
G
fig|444453.5.peg.305
Escherichia coli O157:H7 str. EC4076 (12-325/485)
V
I
AA
L
GG
V
D
NI
S
A
VT
HC
M
TRLRF
V
I
K
D
DALIDSPT
L
K
TIP
GV
L
GV
VR
S
DN
Q
C
QV
I
IG
NT
V
SQ
-
---
A
FQEVV
S
LLPG
-
D
MQPALPVGKPKLTLRRIGA
--
GI
L
DALIG
TM
S
PLIP
AI
I
GG
S
MV
K
-
LLA
M
I
--------
L
E
MSGVLTKG
S
P
T
----
L
T
I
L
NVI
GDG
A
F
F
FLP
L
M
V
AA
SA
AIK
F
KTN
MSL
A
IA
IA
GV
LV
---
HP
SFIELMAK
A
AQGEHV-
-
E
F
ALI
P
V
TAVK
Y
TYT
VIP
A
L
VMT
W
C
L
SY
IE
RW
V
DRIT
P
AVTKNFLK
P
M
LI
V
LI
AAP
LA
I
LLIGP
I
G
I
WI
GSA
IS
ALVYT
I
HGYL
-
GWLSV
A
I
M
G
A
LW
PLL
VMTG
M
H
RVFT
L
TI
I
QTI
--
AET
G
fig|444452.5.peg.2947
Escherichia coli O157:H7 str. EC4113 (12-325/485)
V
I
AA
L
GG
V
D
NI
S
A
VT
HC
M
TRLRF
V
I
K
D
DALIDSPT
L
K
TIP
GV
L
GV
VR
S
DN
Q
C
QV
I
IG
NT
V
SQ
-
---
A
FQEVV
S
LLPG
-
D
MQPALPVGKPKLTLRRIGA
--
GI
L
DALIG
TM
S
PLIP
AI
I
GG
S
MV
K
-
LLA
M
I
--------
L
E
MSGVLTKG
S
P
T
----
L
T
I
L
NVI
GDG
A
F
F
FLP
L
M
V
AA
SA
AIK
F
KTN
MSL
A
IA
IA
GV
LV
---
HP
SFIELMAK
A
AQGEHV-
-
E
F
ALI
P
V
TAVK
Y
TYT
VIP
A
L
VMT
W
C
L
SY
IE
RW
V
DRIT
P
AVTKNFLK
P
M
LI
V
LI
AAP
LA
I
LLIGP
I
G
I
WI
GSA
IS
ALVYT
I
HGYL
-
GWLSV
A
I
M
G
A
LW
PLL
VMTG
M
H
RVFT
L
TI
I
QTI
--
AET
G
fig|444450.8.peg.3911
Escherichia coli O157:H7 str. EC4115 (12-325/485)
V
I
AA
L
GG
V
D
NI
S
A
VT
HC
M
TRLRF
V
I
K
D
DALIDSPT
L
K
TIP
GV
L
GV
VR
S
DN
Q
C
QV
I
IG
NT
V
SQ
-
---
A
FQEVV
S
LLPG
-
D
MQPALPVGKPKLTLRRIGA
--
GI
L
DALIG
TM
S
PLIP
AI
I
GG
S
MV
K
-
LLA
M
I
--------
L
E
MSGVLTKG
S
P
T
----
L
T
I
L
NVI
GDG
A
F
F
FLP
L
M
V
AA
SA
AIK
F
KTN
MSL
A
IA
IA
GV
LV
---
HP
SFIELMAK
A
AQGEHV-
-
E
F
ALI
P
V
TAVK
Y
TYT
VIP
A
L
VMT
W
C
L
SY
IE
RW
V
DRIT
P
AVTKNFLK
P
M
LI
V
LI
AAP
LA
I
LLIGP
I
G
I
WI
GSA
IS
ALVYT
I
HGYL
-
GWLSV
A
I
M
G
A
LW
PLL
VMTG
M
H
RVFT
L
TI
I
QTI
--
AET
G
fig|444451.5.peg.2391
Escherichia coli O157:H7 str. EC4196 (12-325/485)
V
I
AA
L
GG
V
D
NI
S
A
VT
HC
M
TRLRF
V
I
K
D
DALIDSPT
L
K
TIP
GV
L
GV
VR
S
DN
Q
C
QV
I
IG
NT
V
SQ
-
---
A
FQEVV
S
LLPG
-
D
MQPALPVGKPKLTLRRIGA
--
GI
L
DALIG
TM
S
PLIP
AI
I
GG
S
MV
K
-
LLA
M
I
--------
L
E
MSGVLTKG
S
P
T
----
L
T
I
L
NVI
GDG
A
F
F
FLP
L
M
V
AA
SA
AIK
F
KTN
MSL
A
IA
IA
GV
LV
---
HP
SFIELMAK
A
AQGEHV-
-
E
F
ALI
P
V
TAVK
Y
TYT
VIP
A
L
VMT
W
C
L
SY
IE
RW
V
DRIT
P
AVTKNFLK
P
M
LI
V
LI
AAP
LA
I
LLIGP
I
G
I
WI
GSA
IS
ALVYT
I
HGYL
-
GWLSV
A
I
M
G
A
LW
PLL
VMTG
M
H
RVFT
L
TI
I
QTI
--
AET
G
fig|444447.5.peg.969
Escherichia coli O157:H7 str. EC4206 (12-325/485)
V
I
AA
L
GG
V
D
NI
S
A
VT
HC
M
TRLRF
V
I
K
D
DALIDSPT
L
K
TIP
GV
L
GV
VR
S
DN
Q
C
QV
I
IG
NT
V
SQ
-
---
A
FQEVV
S
LLPG
-
D
MQPALPVGKPKLTLRRIGA
--
GI
L
DALIG
TM
S
PLIP
AI
I
GG
S
MV
K
-
LLA
M
I
--------
L
E
MSGVLTKG
S
P
T
----
L
T
I
L
NVI
GDG
A
F
F
FLP
L
M
V
AA
SA
AIK
F
KTN
MSL
A
IA
IA
GV
LV
---
HP
SFIELMAK
A
AQGEHV-
-
E
F
ALI
P
V
TAVK
Y
TYT
VIP
A
L
VMT
W
C
L
SY
IE
RW
V
DRIT
P
AVTKNFLK
P
M
LI
V
LI
AAP
LA
I
LLIGP
I
G
I
WI
GSA
IS
ALVYT
I
HGYL
-
GWLSV
A
I
M
G
A
LW
PLL
VMTG
M
H
RVFT
L
TI
I
QTI
--
AET
G
fig|478004.5.peg.2236
Escherichia coli O157:H7 str. EC4401 (12-325/485)
V
I
AA
L
GG
V
D
NI
S
A
VT
HC
M
TRLRF
V
I
K
D
DALIDSPT
L
K
TIP
GV
L
GV
VR
S
DN
Q
C
QV
I
IG
NT
V
SQ
-
---
A
FQEVV
S
LLPG
-
D
MQPALPVGKPKLTLRRIGA
--
GI
L
DALIG
TM
S
PLIP
AI
I
GG
S
MV
K
-
LLA
M
I
--------
L
E
MSGVLTKG
S
P
T
----
L
T
I
L
NVI
GDG
A
F
F
FLP
L
M
V
AA
SA
AIK
F
KTN
MSL
A
IA
IA
GV
LV
---
HP
SFIELMAK
A
AQGEHV-
-
E
F
ALI
P
V
TAVK
Y
TYT
VIP
A
L
VMT
W
C
L
SY
IE
RW
V
DRIT
P
AVTKNFLK
P
M
LI
V
LI
AAP
LA
I
LLIGP
I
G
I
WI
GSA
IS
ALVYT
I
HGYL
-
GWLSV
A
I
M
G
A
LW
PLL
VMTG
M
H
RVFT
L
TI
I
QTI
--
AET
G
fig|478005.5.peg.2780
Escherichia coli O157:H7 str. EC4486 (12-325/485)
V
I
AA
L
GG
V
D
NI
S
A
VT
HC
M
TRLRF
V
I
K
D
DALIDSPT
L
K
TIP
GV
L
GV
VR
S
DN
Q
C
QV
I
IG
NT
V
SQ
-
---
A
FQEVV
S
LLPG
-
D
MQPALPVGKPKLTLRRIGA
--
GI
L
DALIG
TM
S
PLIP
AI
I
GG
S
MV
K
-
LLA
M
I
--------
L
E
MSGVLTKG
S
P
T
----
L
T
I
L
NVI
GDG
A
F
F
FLP
L
M
V
AA
SA
AIK
F
KTN
MSL
A
IA
IA
GV
LV
---
HP
SFIELMAK
A
AQGEHV-
-
E
F
ALI
P
V
TAVK
Y
TYT
VIP
A
L
VMT
W
C
L
SY
IE
RW
V
DRIT
P
AVTKNFLK
P
M
LI
V
LI
AAP
LA
I
LLIGP
I
G
I
WI
GSA
IS
ALVYT
I
HGYL
-
GWLSV
A
I
M
G
A
LW
PLL
VMTG
M
H
RVFT
L
TI
I
QTI
--
AET
G
fig|478007.5.peg.2901
Escherichia coli O157:H7 str. EC508 (12-325/485)
V
I
AA
L
GG
V
D
NI
S
A
VT
HC
M
TRLRF
V
I
K
D
DALIDSPT
L
K
TIP
GV
L
GV
VR
S
DN
Q
C
QV
I
IG
NT
V
SQ
-
---
A
FQEVV
S
LLPG
-
D
MQPALPVGKPKLTLRRIGA
--
GI
L
DALIG
TM
S
PLIP
AI
I
GG
S
MV
K
-
LLA
M
I
--------
L
E
MSGVLTKG
S
P
T
----
L
T
I
L
NVI
GDG
A
F
F
FLP
L
M
V
AA
SA
AIK
F
KTN
MSL
A
IA
IA
GV
LV
---
HP
SFIELMAK
A
AQGEHV-
-
E
F
ALI
P
V
TAVK
Y
TYT
VIP
A
L
VMT
W
C
L
SY
IE
RW
V
DRIT
P
AVTKNFLK
P
M
LI
V
LI
AAP
LA
I
LLIGP
I
G
I
WI
GSA
IS
ALVYT
I
HGYL
-
GWLSV
A
I
M
G
A
LW
PLL
VMTG
M
H
RVFT
L
TI
I
QTI
--
AET
G
fig|544404.4.peg.3715
Escherichia coli O157:H7 str. TW14359 (12-325/485)
V
I
AA
L
GG
V
D
NI
S
A
VT
HC
M
TRLRF
V
I
K
D
DALIDSPT
L
K
TIP
GV
L
GV
VR
S
DN
Q
C
QV
I
IG
NT
V
SQ
-
---
A
FQEVV
S
LLPG
-
D
MQPALPVGKPKLTLRRIGA
--
GI
L
DALIG
TM
S
PLIP
AI
I
GG
S
MV
K
-
LLA
M
I
--------
L
E
MSGVLTKG
S
P
T
----
L
T
I
L
NVI
GDG
A
F
F
FLP
L
M
V
AA
SA
AIK
F
KTN
MSL
A
IA
IA
GV
LV
---
HP
SFIELMAK
A
AQGEHV-
-
E
F
ALI
P
V
TAVK
Y
TYT
VIP
A
L
VMT
W
C
L
SY
IE
RW
V
DRIT
P
AVTKNFLK
P
M
LI
V
LI
AAP
LA
I
LLIGP
I
G
I
WI
GSA
IS
ALVYT
I
HGYL
-
GWLSV
A
I
M
G
A
LW
PLL
VMTG
M
H
RVFT
L
TI
I
QTI
--
AET
G
fig|679205.4.peg.3878
Escherichia coli MS 124-1 (12-325/485)
V
I
AA
L
GG
V
D
NI
S
A
VT
HC
M
TRLRF
V
I
K
D
DQLIDSPT
L
K
TIP
GV
L
GV
VR
S
DN
Q
C
QV
I
IG
NT
V
SQ
-
---
A
FQEVV
S
LLPG
-
D
MQPAQPVGKPKLTLRRIGA
--
GI
L
DALIG
TM
S
PLIP
AI
I
GG
S
MV
K
-
LLA
M
I
--------
L
E
MSGVLTKG
S
P
T
----
L
T
I
L
NVI
GDG
A
F
F
FLP
L
M
V
AA
SA
AIK
F
KTN
MSL
A
IA
IA
GV
LV
---
HP
SFIELMAK
A
AQGEHV-
-
E
F
ALI
P
V
TAVK
Y
TYT
VIP
A
L
VMT
W
C
L
SY
IE
RW
V
DRIT
P
AVTKNFLK
P
M
LI
V
LI
AAP
LA
I
LLIGP
I
G
I
WI
GSA
IS
ALVYT
I
HGYL
-
GWLSV
A
I
M
G
A
LW
PLL
VMTG
M
H
RVFT
P
TI
I
QTI
--
AET
G
fig|749533.3.peg.4209
Escherichia coli MS 84-1 (12-325/485)
V
I
AA
L
GG
V
D
NI
S
A
VT
HC
M
TRLRF
V
I
K
D
DQLIDSPT
L
K
TIP
GV
L
GV
VR
S
DN
Q
C
QV
I
IG
NT
V
SQ
-
---
A
FQEVV
S
LLPG
-
D
MQPAQPVGKPKLTLRRIGA
--
GI
L
DALIG
TM
S
PLIP
AI
I
GG
S
MV
K
-
LLA
M
I
--------
L
E
MSGVLTKG
S
P
T
----
L
T
I
L
NVI
GDG
A
F
F
FLP
L
M
V
AA
SA
AIK
F
KTN
MSL
A
IA
IA
GV
LV
---
HP
SFIELMAK
A
AQGEHV-
-
E
F
ALI
P
V
TAVK
Y
TYT
VIP
A
L
VMT
W
C
L
SY
IE
RW
V
DRIT
P
AVTKNFLK
P
M
LI
V
LI
AAP
LA
I
LLIGP
I
G
I
WI
GSA
IS
ALVYT
I
HGYL
-
GWLSV
A
I
M
G
A
LW
PLL
VMTG
M
H
RVFT
P
TI
I
QTI
--
AET
G
fig|562.371.peg.5919
Escherichia coli 1044A (12-325/485)
V
I
AA
L
GG
V
D
NI
S
A
VT
HC
M
TRLRF
V
I
K
D
DALIDSPT
L
K
TIP
GV
L
GV
VR
S
DN
Q
C
QV
I
IG
NT
V
SQ
-
---
A
FQEVV
S
LLPG
-
D
MQPALPVGKPKLTLRRIGA
--
GI
L
DALIG
TM
S
PLIP
AI
I
GG
S
MV
K
-
LLA
M
I
--------
L
E
MSGVLTKG
S
P
T
----
L
T
I
L
NVI
GDG
A
F
F
FLP
L
M
V
AA
SA
AIK
F
KTN
MSL
A
IA
IA
GV
LV
---
HP
SFIELMAK
A
AQGEHV-
-
E
F
ALI
P
V
TAVK
Y
TYT
VIP
A
L
VMT
W
C
L
SY
IE
RW
V
DRIT
P
AVTKNFLK
P
M
LI
V
LI
AAP
LA
I
LLIGP
I
G
I
WI
GSA
IS
ALVYT
I
HGYL
-
GWLSV
A
I
M
G
A
LW
PLL
VMTG
M
H
RVFT
L
TI
I
QTI
--
AET
G
fig|562.372.peg.2142
Escherichia coli 1212A (12-325/485)
V
I
AA
L
GG
V
D
NI
S
A
VT
HC
M
TRLRF
V
I
K
D
DALIDSPT
L
K
TIP
GV
L
GV
VR
S
DN
Q
C
QV
I
IG
NT
V
SQ
-
---
A
FQEVV
S
LLPG
-
D
MQPALPVGKPKLTLRRIGA
--
GI
L
DALIG
TM
S
PLIP
AI
I
GG
S
MV
K
-
LLA
M
I
--------
L
E
MSGVLTKG
S
P
T
----
L
T
I
L
NVI
GDG
A
F
F
FLP
L
M
V
AA
SA
AIK
F
KTN
MSL
A
IA
IA
GV
LV
---
HP
SFIELMAK
A
AQGEHV-
-
E
F
ALI
P
V
TAVK
Y
TYT
VIP
A
L
VMT
W
C
L
SY
IE
RW
V
DRIT
P
AVTKNFLK
P
M
LI
V
LI
AAP
LA
I
LLIGP
I
G
I
WI
GSA
IS
ALVYT
I
HGYL
-
GWLSV
A
I
M
G
A
LW
PLL
VMTG
M
H
RVFT
L
TI
I
QTI
--
AET
G
fig|562.374.peg.3980
Escherichia coli 536A (12-325/485)
V
I
AA
L
GG
V
D
NI
S
A
VT
HC
M
TRLRF
V
I
K
D
DALIDSPT
L
K
TIP
GV
L
GV
VR
S
DN
Q
C
QV
I
IG
NT
V
SQ
-
---
A
FQEVV
S
LLPG
-
D
MQPALPVGKPKLTLRRIGA
--
GI
L
DALIG
TM
S
PLIP
AI
I
GG
S
MV
K
-
LLA
M
I
--------
L
E
MSGVLTKG
S
P
T
----
L
T
I
L
NVI
GDG
A
F
F
FLP
L
M
V
AA
SA
AIK
F
KTN
MSL
A
IA
IA
GV
LV
---
HP
SFIELMAK
A
AQGEHV-
-
E
F
ALI
P
V
TAVK
Y
TYT
VIP
A
L
VMT
W
C
L
SY
IE
RW
V
DRIT
P
AVTKNFLK
P
M
LI
V
LI
AAP
LA
I
LLIGP
I
G
I
WI
GSA
IS
ALVYT
I
HGYL
-
GWLSV
A
I
M
G
A
LW
PLL
VMTG
M
H
RVFT
L
TI
I
QTI
--
AET
G
fig|83334.1.peg.3564
Escherichia coli O157:H7 (12-325/485)
V
I
AA
L
GG
V
D
NI
S
A
VT
HC
M
TRLRF
V
I
K
D
DALIDSPT
L
K
TIP
GV
L
GV
VR
S
DN
Q
C
QV
I
IG
NT
V
SQ
-
---
A
FQEVV
S
LLPG
-
D
MQPALPVGKPKLTLRRIGA
--
GI
L
DALIG
TM
S
PLIP
AI
I
GG
S
MV
K
-
LLA
M
I
--------
L
E
MSGVLTKG
S
P
T
----
L
T
I
L
NVI
GDG
A
F
F
FLP
L
M
V
AA
SA
AIK
F
KTN
MSL
A
IA
IA
GV
LV
---
HP
SFIELMAK
A
AQGEHV-
-
E
F
ALI
P
V
TAVK
Y
TYT
VIP
A
L
VMT
W
C
L
SY
IE
RW
V
DRIT
P
AVTKNFLK
P
M
LI
V
LI
AAP
LA
I
LLIGP
I
G
I
WI
GSA
IS
ALVYT
I
HGYL
-
GWLSV
A
I
M
G
A
LW
PLL
VMTG
M
H
RVFT
L
TI
I
QTI
--
AET
G
fig|155864.1.peg.3572
Escherichia coli O157:H7 EDL933 (12-325/485)
V
I
AA
L
GG
V
D
NI
S
A
VT
HC
M
TRLRF
V
I
K
D
DALIDSPT
L
K
TIP
GV
L
GV
VR
S
DN
Q
C
QV
I
IG
NT
V
SQ
-
---
A
FQEVV
S
LLPG
-
D
MQPALPVGKPKLTLRRIGA
--
GI
L
DALIG
TM
S
PLIP
AI
I
GG
S
MV
K
-
LLA
M
I
--------
L
E
MSGVLTKG
S
P
T
----
L
T
I
L
NVI
GDG
A
F
F
FLP
L
M
V
AA
SA
AIK
F
KTN
MSL
A
IA
IA
GV
LV
---
HP
SFIELMAK
A
AQGEHV-
-
E
F
ALI
P
V
TAVK
Y
TYT
VIP
A
L
VMT
W
C
L
SY
IE
RW
V
DRIT
P
AVTKNFLK
P
M
LI
V
LI
AAP
LA
I
LLIGP
I
G
I
WI
GSA
IS
ALVYT
I
HGYL
-
GWLSV
A
I
M
G
A
LW
PLL
VMTG
M
H
RVFT
L
TI
I
QTI
--
AET
G
fig|155864.8.peg.3487
Escherichia coli O157:H7 EDL933 (12-325/485)
V
I
AA
L
GG
V
D
NI
S
A
VT
HC
M
TRLRF
V
I
K
D
DALIDSPT
L
K
TIP
GV
L
GV
VR
S
DN
Q
C
QV
I
IG
NT
V
SQ
-
---
A
FQEVV
S
LLPG
-
D
MQPALPVGKPKLTLRRIGA
--
GI
L
DALIG
TM
S
PLIP
AI
I
GG
S
MV
K
-
LLA
M
I
--------
L
E
MSGVLTKG
S
P
T
----
L
T
I
L
NVI
GDG
A
F
F
FLP
L
M
V
AA
SA
AIK
F
KTN
MSL
A
IA
IA
GV
LV
---
HP
SFIELMAK
A
AQGEHV-
-
E
F
ALI
P
V
TAVK
Y
TYT
VIP
A
L
VMT
W
C
L
SY
IE
RW
V
DRIT
P
AVTKNFLK
P
M
LI
V
LI
AAP
LA
I
LLIGP
I
G
I
WI
GSA
IS
ALVYT
I
HGYL
-
GWLSV
A
I
M
G
A
LW
PLL
VMTG
M
H
RVFT
L
TI
I
QTI
--
AET
G
fig|478006.5.peg.3321
Escherichia coli O157:H7 str. EC4501 (12-325/485)
V
I
AA
L
GG
V
D
NI
S
A
VT
HC
M
TRLRF
V
I
K
D
DALIDSPT
L
K
TIP
GV
L
GV
VR
S
DN
Q
C
QV
I
IG
NT
V
SQ
-
---
A
FQEVV
S
LLPG
-
D
MQPALPVGKPKLTLRRIGA
--
GI
L
DALIG
TM
S
PLIP
AI
I
GG
S
MV
K
-
LLA
M
I
--------
L
E
MSGVLTKG
S
P
T
----
L
T
I
L
NVI
GDG
A
F
F
FLP
L
M
V
AA
SA
AIK
F
KTN
MSL
A
IA
IA
GV
LV
---
HP
SFIELMAK
A
AQGEHV-
-
E
F
ALI
P
V
TAVK
Y
TYT
VIP
A
L
VMT
W
C
L
SY
IE
RW
V
DRIT
P
AVTKNFLK
P
M
LI
V
LI
AAP
LA
I
LLIGP
I
G
I
WI
GSA
IS
ALVYT
I
HGYL
-
GWLSV
A
I
M
G
A
LW
PLL
VMTG
M
H
RVFT
L
TI
I
QTI
--
AET
G
fig|478008.5.peg.3170
Escherichia coli O157:H7 str. EC869 (12-325/485)
V
I
AA
L
GG
V
D
NI
S
A
VT
HC
M
TRLRF
V
I
K
D
DALIDSPT
L
K
TIP
GV
L
GV
VR
S
DN
Q
C
QV
I
IG
NT
V
SQ
-
---
A
FQEVV
S
LLPG
-
D
MQPALPVGKPKLTLRRIGA
--
GI
L
DALIG
TM
S
PLIP
AI
I
GG
S
MV
K
-
LLA
M
I
--------
L
E
MSGVLTKG
S
P
T
----
L
T
I
L
NVI
GDG
A
F
F
FLP
L
M
V
AA
SA
AIK
F
KTN
MSL
A
IA
IA
GV
LV
---
HP
SFIELMAK
A
AQGEHV-
-
E
F
ALI
P
V
TAVK
Y
TYT
VIP
A
L
VMT
W
C
L
SY
IE
RW
V
DRIT
P
AVTKNFLK
P
M
LI
V
LI
AAP
LA
I
LLIGP
I
G
I
WI
GSA
IS
ALVYT
I
HGYL
-
GWLSV
A
I
M
G
A
LW
PLL
VMTG
M
H
RVFT
L
TI
I
QTI
--
AET
G
fig|637388.3.peg.3109
Escherichia coli O157:H7 str. FRIK2000 (12-325/485)
V
I
AA
L
GG
V
D
NI
S
A
VT
HC
M
TRLRF
V
I
K
D
DALIDSPT
L
K
TIP
GV
L
GV
VR
S
DN
Q
C
QV
I
IG
NT
V
SQ
-
---
A
FQEVV
S
LLPG
-
D
MQPALPVGKPKLTLRRIGA
--
GI
L
DALIG
TM
S
PLIP
AI
I
GG
S
MV
K
-
LLA
M
I
--------
L
E
MSGVLTKG
S
P
T
----
L
T
I
L
NVI
GDG
A
F
F
FLP
L
M
V
AA
SA
AIK
F
KTN
MSL
A
IA
IA
GV
LV
---
HP
SFIELMAK
A
AQGEHV-
-
E
F
ALI
P
V
TAVK
Y
TYT
VIP
A
L
VMT
W
C
L
SY
IE
RW
V
DRIT
P
AVTKNFLK
P
M
LI
V
LI
AAP
LA
I
LLIGP
I
G
I
WI
GSA
IS
ALVYT
I
HGYL
-
GWLSV
A
I
M
G
A
LW
PLL
VMTG
M
H
RVFT
L
TI
I
QTI
--
AET
G
fig|570506.3.peg.2612
Escherichia coli O157:H7 str. FRIK966 (12-325/485)
V
I
AA
L
GG
V
D
NI
S
A
VT
HC
M
TRLRF
V
I
K
D
DALIDSPT
L
K
TIP
GV
L
GV
VR
S
DN
Q
C
QV
I
IG
NT
V
SQ
-
---
A
FQEVV
S
LLPG
-
D
MQPALPVGKPKLTLRRIGA
--
GI
L
DALIG
TM
S
PLIP
AI
I
GG
S
MV
K
-
LLA
M
I
--------
L
E
MSGVLTKG
S
P
T
----
L
T
I
L
NVI
GDG
A
F
F
FLP
L
M
V
AA
SA
AIK
F
KTN
MSL
A
IA
IA
GV
LV
---
HP
SFIELMAK
A
AQGEHV-
-
E
F
ALI
P
V
TAVK
Y
TYT
VIP
A
L
VMT
W
C
L
SY
IE
RW
V
DRIT
P
AVTKNFLK
P
M
LI
V
LI
AAP
LA
I
LLIGP
I
G
I
WI
GSA
IS
ALVYT
I
HGYL
-
GWLSV
A
I
M
G
A
LW
PLL
VMTG
M
H
RVFT
L
TI
I
QTI
--
AET
G
fig|386585.9.peg.3732
Escherichia coli O157:H7 str. Sakai (12-325/485)
V
I
AA
L
GG
V
D
NI
S
A
VT
HC
M
TRLRF
V
I
K
D
DALIDSPT
L
K
TIP
GV
L
GV
VR
S
DN
Q
C
QV
I
IG
NT
V
SQ
-
---
A
FQEVV
S
LLPG
-
D
MQPALPVGKPKLTLRRIGA
--
GI
L
DALIG
TM
S
PLIP
AI
I
GG
S
MV
K
-
LLA
M
I
--------
L
E
MSGVLTKG
S
P
T
----
L
T
I
L
NVI
GDG
A
F
F
FLP
L
M
V
AA
SA
AIK
F
KTN
MSL
A
IA
IA
GV
LV
---
HP
SFIELMAK
A
AQGEHV-
-
E
F
ALI
P
V
TAVK
Y
TYT
VIP
A
L
VMT
W
C
L
SY
IE
RW
V
DRIT
P
AVTKNFLK
P
M
LI
V
LI
AAP
LA
I
LLIGP
I
G
I
WI
GSA
IS
ALVYT
I
HGYL
-
GWLSV
A
I
M
G
A
LW
PLL
VMTG
M
H
RVFT
L
TI
I
QTI
--
AET
G
fig|502346.5.peg.3697
Escherichia coli O157:H7 str. TW14588 (12-325/485)
V
I
AA
L
GG
V
D
NI
S
A
VT
HC
M
TRLRF
V
I
K
D
DALIDSPT
L
K
TIP
GV
L
GV
VR
S
DN
Q
C
QV
I
IG
NT
V
SQ
-
---
A
FQEVV
S
LLPG
-
D
MQPALPVGKPKLTLRRIGA
--
GI
L
DALIG
TM
S
PLIP
AI
I
GG
S
MV
K
-
LLA
M
I
--------
L
E
MSGVLTKG
S
P
T
----
L
T
I
L
NVI
GDG
A
F
F
FLP
L
M
V
AA
SA
AIK
F
KTN
MSL
A
IA
IA
GV
LV
---
HP
SFIELMAK
A
AQGEHV-
-
E
F
ALI
P
V
TAVK
Y
TYT
VIP
A
L
VMT
W
C
L
SY
IE
RW
V
DRIT
P
AVTKNFLK
P
M
LI
V
LI
AAP
LA
I
LLIGP
I
G
I
WI
GSA
IS
ALVYT
I
HGYL
-
GWLSV
A
I
M
G
A
LW
PLL
VMTG
M
H
RVFT
L
TI
I
QTI
--
AET
G
fig|701177.3.peg.3376
Escherichia coli O55:H7 str. CB9615 (12-325/485)
V
I
AA
L
GG
V
D
NI
S
A
VT
HC
M
TRLRF
V
I
K
D
DALIDSPT
L
K
TIP
GV
L
GV
VR
S
DN
Q
C
QV
I
IG
NT
V
SQ
-
---
A
FQEVV
S
LLPG
-
D
MQPALPVGKPKLTLRRIGA
--
GI
L
DALIG
TM
S
PLIP
AI
I
GG
S
MV
K
-
LLA
M
I
--------
L
E
MSGVLTKG
S
P
T
----
L
T
I
L
NVI
GDG
A
F
F
FLP
L
M
V
AA
SA
AIK
F
KTN
MSL
A
IA
IA
GV
LV
---
HP
SFIELMAK
A
AQGEHV-
-
E
F
ALI
P
V
TAVK
Y
TYT
VIP
A
L
VMT
W
C
L
SY
IE
RW
V
DRIT
P
AVTKNFLK
P
M
LI
V
LI
AAP
LA
I
LLIGP
I
G
I
WI
GSA
IS
ALVYT
I
HGYL
-
GWLSV
A
I
M
G
A
LW
PLL
VMTG
M
H
RVFT
L
TI
I
QTI
--
AET
G
fig|316401.4.peg.3287
Escherichia coli ETEC H10407 (12-325/485)
V
I
AA
L
GG
V
D
NI
S
A
VT
HC
M
TRLRF
V
I
K
D
DALIDSPT
L
K
TIP
GV
L
GV
VR
S
DN
Q
C
QV
I
IG
NT
V
SQ
-
---
A
FQEVV
S
LLPG
-
D
MQPAQPVGKPKLTLRRIGA
--
GI
L
DALIG
TM
S
PLIP
AI
I
GG
S
MV
K
-
LLA
M
I
--------
L
E
MSGVLTKG
S
P
T
----
L
T
I
L
NVI
GDG
A
F
F
FLP
L
M
V
AA
SA
AIK
F
KTN
MSL
A
IA
IA
GV
LV
---
HP
SFIELMAK
A
AQGEHV-
-
E
F
ALI
P
V
TAVK
Y
TYT
VIP
A
L
VMT
W
C
L
SY
IE
RW
V
DSIT
P
AVTKNFLK
P
M
LI
V
LI
AAP
LA
I
LLIGP
I
G
I
WI
GSA
IS
ALVYT
I
HGYL
-
SWLSV
A
I
M
G
A
LW
PLL
VMTG
M
H
RVFT
P
TI
I
QTI
--
AET
G
fig|585057.4.peg.2677
Escherichia coli IAI39 (1-346/474)
MAKEISSELLN
T
I
L
TR
VGG
P
GNI
A
S
CG
N
C
M
TRLR
L
G
V
H
D
SSLVDPN-
IK
TLE
GV
K
GV
IL
T
SD
Q
V
QVV
F
G
PG
K
AH
R
AAK
A
MSELL
G
EAPV
Q
D
AAEIAAQNKRQLKAKQTSG
VQ
QF
L
AKFAT
IF
T
PLIP
GF
I
AA
GLLLG
IAT
LI
--------
A
T
VMHVPADA
Q
G
T
LPDA
L
N
F
M
KVF
S
K
G
L
F
T
FL
V
I
L
V
GY
N
A
AQA
FGGT
GVN
G
AI
IA
AL
FLLGY
N
P
TATTGYYA
G
FH-----
-
DF
FGL
PI
---D
P
RGN
I
I
G
V
L
ITA
W
A
C
AR
IE
CM
V
HRFM
P
DDLDMLLT
S
L
IT
LLI
TAT
LA
Y
L
I
I
M
P
L
G
G
W
L
FEG
M
S
WLFMH
L
NS--
-
NPLGC
AV
L
A
G
L
F
LIA
V
V
F
GVH
QGFI
P
VY
L
ALM
--
DSQ
G
FNS
L
F
P
I
L
SM
A
GA
G
Q
fig|585057.6.peg.2680
Escherichia coli IAI39 (1-346/474)
MAKEISSELLN
T
I
L
TR
VGG
P
GNI
A
S
CG
N
C
M
TRLR
L
G
V
H
D
SSLVDPN-
IK
TLE
GV
K
GV
IL
T
SD
Q
V
QVV
F
G
PG
K
AH
R
AAK
A
MSELL
G
EAPV
Q
D
AAEIAAQNKRQLKAKQTSG
VQ
QF
L
AKFAT
IF
T
PLIP
GF
I
AA
GLLLG
IAT
LI
--------
A
T
VMHVPADA
Q
G
T
LPDA
L
N
F
M
KVF
S
K
G
L
F
T
FL
V
I
L
V
GY
N
A
AQA
FGGT
GVN
G
AI
IA
AL
FLLGY
N
P
TATTGYYA
G
FH-----
-
DF
FGL
PI
---D
P
RGN
I
I
G
V
L
ITA
W
A
C
AR
IE
CM
V
HRFM
P
DDLDMLLT
S
L
IT
LLI
TAT
LA
Y
L
I
I
M
P
L
G
G
W
L
FEG
M
S
WLFMH
L
NS--
-
NPLGC
AV
L
A
G
L
F
LIA
V
V
F
GVH
QGFI
P
VY
L
ALM
--
DSQ
G
FNS
L
F
P
I
L
SM
A
GA
G
Q
fig|216593.1.peg.2298
Escherichia coli E2348/69 (1-346/474)
MAKEISSELLN
T
I
L
TR
VGG
P
GNI
A
S
CG
N
C
M
TRLR
L
G
V
H
D
SSLVDPN-
IK
TLE
GV
K
GV
IL
T
SD
Q
V
QVV
F
G
PG
K
AH
R
AAK
A
MSELL
G
EAPV
Q
D
AAEIAAQNKRQLKAKQTSG
VQ
QF
L
AKFAT
IF
T
PLIP
GF
I
AA
GLLLG
IAT
LI
--------
A
T
VMHVPADA
Q
G
T
LPDA
L
N
F
M
KVF
S
K
G
L
F
T
FL
V
I
L
V
GY
N
A
AQA
FGGT
GVN
G
AI
IA
AL
FLLGY
N
P
TATTGYYA
G
FH-----
-
DF
FGL
PI
---D
P
RGN
I
I
G
V
L
IAA
W
A
C
AR
IE
GM
V
RHFM
P
DDLDMLLT
S
L
IT
LLI
TAT
LA
Y
L
I
I
M
P
L
G
G
W
L
FEG
M
S
WLFMH
L
NS--
-
NPLGC
AV
L
A
G
L
F
LIA
V
V
F
GVH
QGFI
P
VY
L
ALM
--
DSQ
G
FNS
L
F
P
I
L
SM
A
GA
G
Q
fig|670888.3.peg.3604
Escherichia coli 1827-70 (12-325/485)
V
I
AA
L
GG
V
D
NI
S
A
VT
HC
M
TRLRF
V
I
K
D
DALIDSPT
L
K
TIP
GV
L
GV
VR
S
DN
Q
C
QV
I
IG
NT
V
SQ
-
---
A
FQEVV
S
LLPG
-
D
MQPAQPVGKPKLTLRRIGA
--
GI
L
DALIG
TM
S
PLIP
AI
I
GG
S
MV
K
-
LLA
M
I
--------
L
E
MSGVLTKG
S
P
T
----
L
T
I
L
NVI
GDG
A
F
F
FLP
L
M
V
AA
SA
AIK
F
KTN
MSL
A
IA
IA
GV
LV
---
HP
SFIELMAK
A
AQGEHV-
-
E
F
ALI
P
V
TAVK
Y
TYT
VIP
A
L
VMT
W
C
L
SY
IE
RW
V
DSIT
P
AVTKNFLK
P
M
LI
V
LI
AAP
LA
I
LLIGP
I
G
I
WI
GSA
IS
ALVYT
I
HGYL
-
GWLSV
A
I
M
G
A
LW
PLL
VMTG
M
H
RVFT
P
TI
I
QTI
--
AET
G
fig|344610.3.peg.3737
Escherichia coli 53638 (12-325/485)
V
I
AA
L
GG
V
D
NI
S
A
VT
HC
M
TRLRF
V
I
K
D
DALIDSPT
L
K
TIP
GV
L
GV
VR
S
DN
Q
C
QV
I
IG
NT
V
SQ
-
---
A
FQEVV
S
LLPG
-
D
MQPAQPVGKPKLTLRRIGA
--
GI
L
DALIG
TM
S
PLIP
AI
I
GG
S
MV
K
-
LLA
M
I
--------
L
E
MSGVLTKG
S
P
T
----
L
T
I
L
NVI
GDG
A
F
F
FLP
L
M
V
AA
SA
AIK
F
KTN
MSL
A
IA
IA
GV
LV
---
HP
SFIELMAK
A
AQGEHV-
-
E
F
ALI
P
V
TAVK
Y
TYT
VIP
A
L
VMT
W
C
L
SY
IE
RW
V
DSIT
P
AVTKNFLK
P
M
LI
V
LI
AAP
LA
I
LLIGP
I
G
I
WI
GSA
IS
ALVYT
I
HGYL
-
GWLSV
A
I
M
G
A
LW
PLL
VMTG
M
H
RVFT
P
TI
I
QTI
--
AET
G
fig|344610.7.peg.3567
Escherichia coli 53638 (12-325/485)
V
I
AA
L
GG
V
D
NI
S
A
VT
HC
M
TRLRF
V
I
K
D
DALIDSPT
L
K
TIP
GV
L
GV
VR
S
DN
Q
C
QV
I
IG
NT
V
SQ
-
---
A
FQEVV
S
LLPG
-
D
MQPAQPVGKPKLTLRRIGA
--
GI
L
DALIG
TM
S
PLIP
AI
I
GG
S
MV
K
-
LLA
M
I
--------
L
E
MSGVLTKG
S
P
T
----
L
T
I
L
NVI
GDG
A
F
F
FLP
L
M
V
AA
SA
AIK
F
KTN
MSL
A
IA
IA
GV
LV
---
HP
SFIELMAK
A
AQGEHV-
-
E
F
ALI
P
V
TAVK
Y
TYT
VIP
A
L
VMT
W
C
L
SY
IE
RW
V
DSIT
P
AVTKNFLK
P
M
LI
V
LI
AAP
LA
I
LLIGP
I
G
I
WI
GSA
IS
ALVYT
I
HGYL
-
GWLSV
A
I
M
G
A
LW
PLL
VMTG
M
H
RVFT
P
TI
I
QTI
--
AET
G
fig|481805.3.peg.1066
Escherichia coli ATCC 8739 (12-325/485)
V
I
AA
L
GG
V
D
NI
S
A
VT
HC
M
TRLRF
V
I
K
D
DALIDSPT
L
K
TIP
GV
L
GV
VR
S
DN
Q
C
QV
I
IG
NT
V
SQ
-
---
A
FQEVV
S
LLPG
-
D
MQPAQPVGKPKLTLRRIGA
--
GI
L
DALIG
TM
S
PLIP
AI
I
GG
S
MV
K
-
LLA
M
I
--------
L
E
MSGVLTKG
S
P
T
----
L
T
I
L
NVI
GDG
A
F
F
FLP
L
M
V
AA
SA
AIK
F
KTN
MSL
A
IA
IA
GV
LV
---
HP
SFIELMAK
A
AQGEHV-
-
E
F
ALI
P
V
TAVK
Y
TYT
VIP
A
L
VMT
W
C
L
SY
IE
RW
V
DSIT
P
AVTKNFLK
P
M
LI
V
LI
AAP
LA
I
LLIGP
I
G
I
WI
GSA
IS
ALVYT
I
HGYL
-
GWLSV
A
I
M
G
A
LW
PLL
VMTG
M
H
RVFT
P
TI
I
QTI
--
AET
G
fig|481805.6.peg.1063
Escherichia coli ATCC 8739 (12-325/485)
V
I
AA
L
GG
V
D
NI
S
A
VT
HC
M
TRLRF
V
I
K
D
DALIDSPT
L
K
TIP
GV
L
GV
VR
S
DN
Q
C
QV
I
IG
NT
V
SQ
-
---
A
FQEVV
S
LLPG
-
D
MQPAQPVGKPKLTLRRIGA
--
GI
L
DALIG
TM
S
PLIP
AI
I
GG
S
MV
K
-
LLA
M
I
--------
L
E
MSGVLTKG
S
P
T
----
L
T
I
L
NVI
GDG
A
F
F
FLP
L
M
V
AA
SA
AIK
F
KTN
MSL
A
IA
IA
GV
LV
---
HP
SFIELMAK
A
AQGEHV-
-
E
F
ALI
P
V
TAVK
Y
TYT
VIP
A
L
VMT
W
C
L
SY
IE
RW
V
DSIT
P
AVTKNFLK
P
M
LI
V
LI
AAP
LA
I
LLIGP
I
G
I
WI
GSA
IS
ALVYT
I
HGYL
-
GWLSV
A
I
M
G
A
LW
PLL
VMTG
M
H
RVFT
P
TI
I
QTI
--
AET
G
fig|595496.3.peg.2688
Escherichia coli BW2952 (12-325/485)
V
I
AA
L
GG
V
D
NI
S
A
VT
HC
M
TRLRF
V
I
K
D
DALIDSPT
L
K
TIP
GV
L
GV
VR
S
DN
Q
C
QV
I
IG
NT
V
SQ
-
---
A
FQEVV
S
LLPG
-
D
MQPAQPVGKPKLTLRRIGA
--
GI
L
DALIG
TM
S
PLIP
AI
I
GG
S
MV
K
-
LLA
M
I
--------
L
E
MSGVLTKG
S
P
T
----
L
T
I
L
NVI
GDG
A
F
F
FLP
L
M
V
AA
SA
AIK
F
KTN
MSL
A
IA
IA
GV
LV
---
HP
SFIELMAK
A
AQGEHV-
-
E
F
ALI
P
V
TAVK
Y
TYT
VIP
A
L
VMT
W
C
L
SY
IE
RW
V
DSIT
P
AVTKNFLK
P
M
LI
V
LI
AAP
LA
I
LLIGP
I
G
I
WI
GSA
IS
ALVYT
I
HGYL
-
GWLSV
A
I
M
G
A
LW
PLL
VMTG
M
H
RVFT
P
TI
I
QTI
--
AET
G
fig|536056.3.peg.1020
Escherichia coli DH1 (12-325/485)
V
I
AA
L
GG
V
D
NI
S
A
VT
HC
M
TRLRF
V
I
K
D
DALIDSPT
L
K
TIP
GV
L
GV
VR
S
DN
Q
C
QV
I
IG
NT
V
SQ
-
---
A
FQEVV
S
LLPG
-
D
MQPAQPVGKPKLTLRRIGA
--
GI
L
DALIG
TM
S
PLIP
AI
I
GG
S
MV
K
-
LLA
M
I
--------
L
E
MSGVLTKG
S
P
T
----
L
T
I
L
NVI
GDG
A
F
F
FLP
L
M
V
AA
SA
AIK
F
KTN
MSL
A
IA
IA
GV
LV
---
HP
SFIELMAK
A
AQGEHV-
-
E
F
ALI
P
V
TAVK
Y
TYT
VIP
A
L
VMT
W
C
L
SY
IE
RW
V
DSIT
P
AVTKNFLK
P
M
LI
V
LI
AAP
LA
I
LLIGP
I
G
I
WI
GSA
IS
ALVYT
I
HGYL
-
GWLSV
A
I
M
G
A
LW
PLL
VMTG
M
H
RVFT
P
TI
I
QTI
--
AET
G
fig|656414.3.peg.3148
Escherichia coli H736 (12-325/485)
V
I
AA
L
GG
V
D
NI
S
A
VT
HC
M
TRLRF
V
I
K
D
DALIDSPT
L
K
TIP
GV
L
GV
VR
S
DN
Q
C
QV
I
IG
NT
V
SQ
-
---
A
FQEVV
S
LLPG
-
D
MQPAQPVGKPKLTLRRIGA
--
GI
L
DALIG
TM
S
PLIP
AI
I
GG
S
MV
K
-
LLA
M
I
--------
L
E
MSGVLTKG
S
P
T
----
L
T
I
L
NVI
GDG
A
F
F
FLP
L
M
V
AA
SA
AIK
F
KTN
MSL
A
IA
IA
GV
LV
---
HP
SFIELMAK
A
AQGEHV-
-
E
F
ALI
P
V
TAVK
Y
TYT
VIP
A
L
VMT
W
C
L
SY
IE
RW
V
DSIT
P
AVTKNFLK
P
M
LI
V
LI
AAP
LA
I
LLIGP
I
G
I
WI
GSA
IS
ALVYT
I
HGYL
-
GWLSV
A
I
M
G
A
LW
PLL
VMTG
M
H
RVFT
P
TI
I
QTI
--
AET
G
fig|331112.3.peg.2668
Escherichia coli HS (12-325/485)
V
I
AA
L
GG
V
D
NI
S
A
VT
HC
M
TRLRF
V
I
K
D
DALIDSPT
L
K
TIP
GV
L
GV
VR
S
DN
Q
C
QV
I
IG
NT
V
SQ
-
---
A
FQEVV
S
LLPG
-
D
MQPAQPVGKPKLTLRRIGA
--
GI
L
DALIG
TM
S
PLIP
AI
I
GG
S
MV
K
-
LLA
M
I
--------
L
E
MSGVLTKG
S
P
T
----
L
T
I
L
NVI
GDG
A
F
F
FLP
L
M
V
AA
SA
AIK
F
KTN
MSL
A
IA
IA
GV
LV
---
HP
SFIELMAK
A
AQGEHV-
-
E
F
ALI
P
V
TAVK
Y
TYT
VIP
A
L
VMT
W
C
L
SY
IE
RW
V
DSIT
P
AVTKNFLK
P
M
LI
V
LI
AAP
LA
I
LLIGP
I
G
I
WI
GSA
IS
ALVYT
I
HGYL
-
GWLSV
A
I
M
G
A
LW
PLL
VMTG
M
H
RVFT
P
TI
I
QTI
--
AET
G
fig|331112.6.peg.2783
Escherichia coli HS (12-325/485)
V
I
AA
L
GG
V
D
NI
S
A
VT
HC
M
TRLRF
V
I
K
D
DALIDSPT
L
K
TIP
GV
L
GV
VR
S
DN
Q
C
QV
I
IG
NT
V
SQ
-
---
A
FQEVV
S
LLPG
-
D
MQPAQPVGKPKLTLRRIGA
--
GI
L
DALIG
TM
S
PLIP
AI
I
GG
S
MV
K
-
LLA
M
I
--------
L
E
MSGVLTKG
S
P
T
----
L
T
I
L
NVI
GDG
A
F
F
FLP
L
M
V
AA
SA
AIK
F
KTN
MSL
A
IA
IA
GV
LV
---
HP
SFIELMAK
A
AQGEHV-
-
E
F
ALI
P
V
TAVK
Y
TYT
VIP
A
L
VMT
W
C
L
SY
IE
RW
V
DSIT
P
AVTKNFLK
P
M
LI
V
LI
AAP
LA
I
LLIGP
I
G
I
WI
GSA
IS
ALVYT
I
HGYL
-
GWLSV
A
I
M
G
A
LW
PLL
VMTG
M
H
RVFT
P
TI
I
QTI
--
AET
G
fig|749538.3.peg.586
Escherichia coli MS 116-1 (12-325/485)
V
I
AA
L
GG
V
D
NI
S
A
VT
HC
M
TRLRF
V
I
K
D
DALIDSPT
L
K
TIP
GV
L
GV
VR
S
DN
Q
C
QV
I
IG
NT
V
SQ
-
---
A
FQEVV
S
LLPG
-
D
MQPAQPVGKPKLTLRRIGA
--
GI
L
DALIG
TM
S
PLIP
AI
I
GG
S
MV
K
-
LLA
M
I
--------
L
E
MSGVLTKG
S
P
T
----
L
T
I
L
NVI
GDG
A
F
F
FLP
L
M
V
AA
SA
AIK
F
KTN
MSL
A
IA
IA
GV
LV
---
HP
SFIELMAK
A
AQGEHV-
-
E
F
ALI
P
V
TAVK
Y
TYT
VIP
A
L
VMT
W
C
L
SY
IE
RW
V
DSIT
P
AVTKNFLK
P
M
LI
V
LI
AAP
LA
I
LLIGP
I
G
I
WI
GSA
IS
ALVYT
I
HGYL
-
GWLSV
A
I
M
G
A
LW
PLL
VMTG
M
H
RVFT
P
TI
I
QTI
--
AET
G
fig|749548.3.peg.3326
Escherichia coli MS 196-1 (12-325/485)
V
I
AA
L
GG
V
D
NI
S
A
VT
HC
M
TRLRF
V
I
K
D
DALIDSPT
L
K
TIP
GV
L
GV
VR
S
DN
Q
C
QV
I
IG
NT
V
SQ
-
---
A
FQEVV
S
LLPG
-
D
MQPAQPVGKPKLTLRRIGA
--
GI
L
DALIG
TM
S
PLIP
AI
I
GG
S
MV
K
-
LLA
M
I
--------
L
E
MSGVLTKG
S
P
T
----
L
T
I
L
NVI
GDG
A
F
F
FLP
L
M
V
AA
SA
AIK
F
KTN
MSL
A
IA
IA
GV
LV
---
HP
SFIELMAK
A
AQGEHV-
-
E
F
ALI
P
V
TAVK
Y
TYT
VIP
A
L
VMT
W
C
L
SY
IE
RW
V
DSIT
P
AVTKNFLK
P
M
LI
V
LI
AAP
LA
I
LLIGP
I
G
I
WI
GSA
IS
ALVYT
I
HGYL
-
GWLSV
A
I
M
G
A
LW
PLL
VMTG
M
H
RVFT
P
TI
I
QTI
--
AET
G
fig|316407.3.peg.2618
Escherichia coli W3110 (12-325/485)
V
I
AA
L
GG
V
D
NI
S
A
VT
HC
M
TRLRF
V
I
K
D
DALIDSPT
L
K
TIP
GV
L
GV
VR
S
DN
Q
C
QV
I
IG
NT
V
SQ
-
---
A
FQEVV
S
LLPG
-
D
MQPAQPVGKPKLTLRRIGA
--
GI
L
DALIG
TM
S
PLIP
AI
I
GG
S
MV
K
-
LLA
M
I
--------
L
E
MSGVLTKG
S
P
T
----
L
T
I
L
NVI
GDG
A
F
F
FLP
L
M
V
AA
SA
AIK
F
KTN
MSL
A
IA
IA
GV
LV
---
HP
SFIELMAK
A
AQGEHV-
-
E
F
ALI
P
V
TAVK
Y
TYT
VIP
A
L
VMT
W
C
L
SY
IE
RW
V
DSIT
P
AVTKNFLK
P
M
LI
V
LI
AAP
LA
I
LLIGP
I
G
I
WI
GSA
IS
ALVYT
I
HGYL
-
GWLSV
A
I
M
G
A
LW
PLL
VMTG
M
H
RVFT
P
TI
I
QTI
--
AET
G
fig|316385.5.peg.2836
Escherichia coli str. K-12 substr. DH10B (12-325/485)
V
I
AA
L
GG
V
D
NI
S
A
VT
HC
M
TRLRF
V
I
K
D
DALIDSPT
L
K
TIP
GV
L
GV
VR
S
DN
Q
C
QV
I
IG
NT
V
SQ
-
---
A
FQEVV
S
LLPG
-
D
MQPAQPVGKPKLTLRRIGA
--
GI
L
DALIG
TM
S
PLIP
AI
I
GG
S
MV
K
-
LLA
M
I
--------
L
E
MSGVLTKG
S
P
T
----
L
T
I
L
NVI
GDG
A
F
F
FLP
L
M
V
AA
SA
AIK
F
KTN
MSL
A
IA
IA
GV
LV
---
HP
SFIELMAK
A
AQGEHV-
-
E
F
ALI
P
V
TAVK
Y
TYT
VIP
A
L
VMT
W
C
L
SY
IE
RW
V
DSIT
P
AVTKNFLK
P
M
LI
V
LI
AAP
LA
I
LLIGP
I
G
I
WI
GSA
IS
ALVYT
I
HGYL
-
GWLSV
A
I
M
G
A
LW
PLL
VMTG
M
H
RVFT
P
TI
I
QTI
--
AET
G
fig|316385.7.peg.2902
Escherichia coli str. K-12 substr. DH10B (12-325/485)
V
I
AA
L
GG
V
D
NI
S
A
VT
HC
M
TRLRF
V
I
K
D
DALIDSPT
L
K
TIP
GV
L
GV
VR
S
DN
Q
C
QV
I
IG
NT
V
SQ
-
---
A
FQEVV
S
LLPG
-
D
MQPAQPVGKPKLTLRRIGA
--
GI
L
DALIG
TM
S
PLIP
AI
I
GG
S
MV
K
-
LLA
M
I
--------
L
E
MSGVLTKG
S
P
T
----
L
T
I
L
NVI
GDG
A
F
F
FLP
L
M
V
AA
SA
AIK
F
KTN
MSL
A
IA
IA
GV
LV
---
HP
SFIELMAK
A
AQGEHV-
-
E
F
ALI
P
V
TAVK
Y
TYT
VIP
A
L
VMT
W
C
L
SY
IE
RW
V
DSIT
P
AVTKNFLK
P
M
LI
V
LI
AAP
LA
I
LLIGP
I
G
I
WI
GSA
IS
ALVYT
I
HGYL
-
GWLSV
A
I
M
G
A
LW
PLL
VMTG
M
H
RVFT
P
TI
I
QTI
--
AET
G
fig|511145.12.peg.2807
Escherichia coli str. K-12 substr. MG1655 (12-325/485)
V
I
AA
L
GG
V
D
NI
S
A
VT
HC
M
TRLRF
V
I
K
D
DALIDSPT
L
K
TIP
GV
L
GV
VR
S
DN
Q
C
QV
I
IG
NT
V
SQ
-
---
A
FQEVV
S
LLPG
-
D
MQPAQPVGKPKLTLRRIGA
--
GI
L
DALIG
TM
S
PLIP
AI
I
GG
S
MV
K
-
LLA
M
I
--------
L
E
MSGVLTKG
S
P
T
----
L
T
I
L
NVI
GDG
A
F
F
FLP
L
M
V
AA
SA
AIK
F
KTN
MSL
A
IA
IA
GV
LV
---
HP
SFIELMAK
A
AQGEHV-
-
E
F
ALI
P
V
TAVK
Y
TYT
VIP
A
L
VMT
W
C
L
SY
IE
RW
V
DSIT
P
AVTKNFLK
P
M
LI
V
LI
AAP
LA
I
LLIGP
I
G
I
WI
GSA
IS
ALVYT
I
HGYL
-
GWLSV
A
I
M
G
A
LW
PLL
VMTG
M
H
RVFT
P
TI
I
QTI
--
AET
G
fig|511145.6.peg.2791
Escherichia coli str. K-12 substr. MG1655 (12-325/485)
V
I
AA
L
GG
V
D
NI
S
A
VT
HC
M
TRLRF
V
I
K
D
DALIDSPT
L
K
TIP
GV
L
GV
VR
S
DN
Q
C
QV
I
IG
NT
V
SQ
-
---
A
FQEVV
S
LLPG
-
D
MQPAQPVGKPKLTLRRIGA
--
GI
L
DALIG
TM
S
PLIP
AI
I
GG
S
MV
K
-
LLA
M
I
--------
L
E
MSGVLTKG
S
P
T
----
L
T
I
L
NVI
GDG
A
F
F
FLP
L
M
V
AA
SA
AIK
F
KTN
MSL
A
IA
IA
GV
LV
---
HP
SFIELMAK
A
AQGEHV-
-
E
F
ALI
P
V
TAVK
Y
TYT
VIP
A
L
VMT
W
C
L
SY
IE
RW
V
DSIT
P
AVTKNFLK
P
M
LI
V
LI
AAP
LA
I
LLIGP
I
G
I
WI
GSA
IS
ALVYT
I
HGYL
-
GWLSV
A
I
M
G
A
LW
PLL
VMTG
M
H
RVFT
P
TI
I
QTI
--
AET
G
fig|550677.3.peg.3248
Escherichia coli B354 (12-325/485)
V
I
AA
L
GG
V
D
NI
S
A
VT
HC
M
TRLRF
V
I
K
D
DALIDSPT
L
K
TIS
GV
L
GV
VR
S
DN
Q
C
QV
I
IG
NT
V
SQ
-
---
A
FQEVV
S
LLPG
-
D
MQPAQPVGKPKLTLRRIGA
--
GI
L
DALIG
TM
S
PLIP
AI
I
GG
S
MV
K
-
LLA
M
I
--------
L
E
MSGVLTKG
S
P
T
----
L
T
I
L
NVI
GDG
A
F
F
FLP
L
M
V
AA
SA
AIK
F
KTN
MSL
A
IA
IA
GV
LV
---
HP
SFIELMAK
A
AQGEHV-
-
E
F
ALI
P
V
TAVK
Y
TYT
VIP
A
L
VMT
W
C
L
SY
IE
RW
V
DRIT
P
AVTKNFLK
P
M
LI
V
LI
AAP
LA
I
LLIGP
I
G
I
WI
GSA
IS
ALVYT
I
HGYL
-
GWLSV
A
I
M
G
A
LW
PLL
VMTG
M
H
RVFT
P
TI
I
QTI
--
AET
G
fig|749544.3.peg.832
Escherichia coli MS 175-1 (12-325/485)
V
I
AA
L
GG
V
D
NI
S
A
VT
HC
M
TRLRF
V
I
K
D
DALIDSPT
L
K
TIP
GV
L
GV
VR
S
DN
Q
C
QV
I
IG
NT
V
SQ
-
---
A
FQEVV
S
LLPG
-
D
MQPAQPVGKPKLTLRRIGA
--
GI
L
DALIG
TM
S
PLIP
AI
I
GG
S
MV
K
-
LLA
M
I
--------
L
E
MSGVLTKG
S
P
T
----
L
T
I
L
NVI
GDG
A
F
F
FLP
L
M
V
AA
SA
AIK
F
KTN
MSL
A
IA
IA
GV
LV
---
HP
SFIELMAK
A
AQGEHV-
-
E
F
ALI
P
V
TAVK
Y
TYT
VIP
A
L
VMT
W
C
L
SY
IE
RW
V
DSIT
P
AVTKNFLK
P
M
LI
V
LI
AAP
LA
I
LLIGP
I
G
I
WI
GSA
IS
ALVYT
I
HGYL
-
GWLSV
A
I
M
G
A
LW
PLL
VMTG
M
H
RVFT
P
TI
I
QTI
--
AET
G
fig|340186.3.peg.2401
Escherichia coli E110019 (7-336/625)
K
I
V
AG
VGG
A
D
NI
V
S
LM
HC
A
TRLRF
K
L
K
D
ESKAQAEV
L
K
NTP
G
I
I
M
V
VE
S
GG
Q
F
QVVIG
NH
V
AD
-
VFL
A
VNSVA
G
LGE-
-
-
KAQQAPENDEKGNLLN---
--
RF
V
YVISG
IF
T
PLI
G
LM
A
AT
G
I
L
K
G
MLA
L
A
--------
L
T
FQWTTEQ-
S
G
T
----
Y
L
I
L
FSA
S
D
A
L
F
W
F
F
PI
I
L
GY
T
A
GKR
FGG
N
PFT
A
MV
I
G
GA
LV
---
HP
LILTAFEN
R
QKADAPG
L
DF
LGI
P
V
TLLN
Y
SSS
VIP
I
I
FSA
W
L
C
SI
L
E
RR
L
NAWL
P
SAIKNFFT
PL
LC
L
MV
ITP
VT
F
LL
V
GP
L
S
T
WI
SEM
I
A
AGYLW
L
YQAV
-
PAFAG
AV
M
G
G
F
W
QIF
VM
F
G
L
H
WGLV
P
LC
I
NNF
--
TVL
G
YDT
M
I
PLL
MP
A
IM
AQ
fig|340186.5.peg.2480
Escherichia coli E110019 (7-336/625)
K
I
V
AG
VGG
A
D
NI
V
S
LM
HC
A
TRLRF
K
L
K
D
ESKAQAEV
L
K
NTP
G
I
I
M
V
VE
S
GG
Q
F
QVVIG
NH
V
AD
-
VFL
A
VNSVA
G
LGE-
-
-
KAQQAPENDEKGNLLN---
--
RF
V
YVISG
IF
T
PLI
G
LM
A
AT
G
I
L
K
G
MLA
L
A
--------
L
T
FQWTTEQ-
S
G
T
----
Y
L
I
L
FSA
S
D
A
L
F
W
F
F
PI
I
L
GY
T
A
GKR
FGG
N
PFT
A
MV
I
G
GA
LV
---
HP
LILTAFEN
R
QKADAPG
L
DF
LGI
P
V
TLLN
Y
SSS
VIP
I
I
FSA
W
L
C
SI
L
E
RR
L
NAWL
P
SAIKNFFT
PL
LC
L
MV
ITP
VT
F
LL
V
GP
L
S
T
WI
SEM
I
A
AGYLW
L
YQAV
-
PAFAG
AV
M
G
G
F
W
QIF
VM
F
G
L
H
WGLV
P
LC
I
NNF
--
TVL
G
YDT
M
I
PLL
MP
A
IM
AQ
fig|749540.3.peg.1875
Escherichia coli MS 146-1 (12-325/485)
V
I
AA
L
GG
V
D
NI
S
A
VT
HC
M
TRLRF
V
I
K
D
DALIDSPT
L
K
TIP
GV
L
GV
VR
S
DN
Q
C
QV
I
IG
NT
V
SQ
-
---
A
FQEVV
S
LLPG
-
D
MQPAQPVGKPKLTLRRIGA
--
GI
L
DALIG
TM
S
PLIP
AI
I
GG
S
MV
K
-
LLA
M
I
--------
L
E
MSGVLTKG
S
P
T
----
L
T
I
L
NVI
GDG
A
F
F
F
M
P
L
M
V
AA
SA
AIK
F
KTN
MSL
A
IA
IA
GV
LV
---
HP
SFIELMAK
A
AQGEHV-
-
E
F
ALI
P
V
TAVK
Y
TYT
VIP
A
L
VMT
W
C
L
SY
IE
RW
V
DSIT
P
AVTKNFLK
P
M
LI
V
LI
AAP
LA
I
LLIGP
I
G
I
WI
GSA
IS
ALVYT
I
HGYL
-
GWLSV
A
I
M
G
A
LW
PLL
VMTG
M
H
RVFT
P
TI
I
QTI
--
AET
G
fig|585057.4.peg.3005
Escherichia coli IAI39 (12-325/485)
V
I
AA
L
GG
V
D
NI
S
A
VT
HC
M
TRLRF
V
I
K
D
DQLIDSPT
L
K
TIP
GV
L
GV
VR
S
DN
Q
C
QV
I
IG
NT
V
SQ
-
---
A
FQEVV
S
LLPG
-
D
MQPAQPVGKPKLTLRRIGA
--
GI
L
DALIG
TM
S
PLIP
AI
I
GG
S
MV
K
-
LLA
M
I
--------
L
E
MSGVLTKG
S
P
T
----
L
T
I
L
NVI
GDG
A
F
F
FLP
L
M
V
AA
SA
AIK
F
KTN
MSL
A
IA
IA
GV
LV
---
HP
SFIELMAK
A
AQGEHV-
-
E
F
ALI
P
V
TAVK
Y
TYT
VIP
A
L
VMT
W
C
L
SY
IE
RW
V
DSIT
P
AVTKNFLK
P
M
LI
V
LI
AAP
LA
I
LLIGP
I
G
I
WI
GSA
IS
ALVYT
I
HGYL
-
GWLSV
A
I
M
G
A
LW
PLL
VMTG
M
H
RVFT
P
TI
I
QTI
--
AET
G
fig|585057.6.peg.3010
Escherichia coli IAI39 (12-325/485)
V
I
AA
L
GG
V
D
NI
S
A
VT
HC
M
TRLRF
V
I
K
D
DQLIDSPT
L
K
TIP
GV
L
GV
VR
S
DN
Q
C
QV
I
IG
NT
V
SQ
-
---
A
FQEVV
S
LLPG
-
D
MQPAQPVGKPKLTLRRIGA
--
GI
L
DALIG
TM
S
PLIP
AI
I
GG
S
MV
K
-
LLA
M
I
--------
L
E
MSGVLTKG
S
P
T
----
L
T
I
L
NVI
GDG
A
F
F
FLP
L
M
V
AA
SA
AIK
F
KTN
MSL
A
IA
IA
GV
LV
---
HP
SFIELMAK
A
AQGEHV-
-
E
F
ALI
P
V
TAVK
Y
TYT
VIP
A
L
VMT
W
C
L
SY
IE
RW
V
DSIT
P
AVTKNFLK
P
M
LI
V
LI
AAP
LA
I
LLIGP
I
G
I
WI
GSA
IS
ALVYT
I
HGYL
-
GWLSV
A
I
M
G
A
LW
PLL
VMTG
M
H
RVFT
P
TI
I
QTI
--
AET
G
fig|550676.3.peg.2640
Escherichia coli B185 (12-325/485)
V
I
AA
L
GG
V
D
NI
S
A
VT
HC
M
TRLRF
V
I
K
D
DALIDSPT
L
K
TIP
GV
L
GV
VR
S
DN
Q
C
QV
I
IG
NT
V
SQ
-
---
A
FQEVV
S
LLPG
-
D
MHPALPVGKPKLTLRRIGA
--
GI
L
DALIG
TM
S
PLIP
AI
I
GG
S
MV
K
-
LLA
M
I
--------
L
E
MSGVLTKG
S
P
T
----
L
T
I
L
NVI
GDG
A
F
F
FLP
L
M
V
AA
SA
AIK
F
KTN
MSL
A
IA
IA
GV
LV
---
HP
SFIELMAK
A
AQGEHV-
-
E
F
ALI
P
V
TAVK
Y
TYT
VIP
A
L
VMT
W
C
L
SY
IE
RW
V
DSIT
P
AVTKNFLK
P
M
LI
V
LI
AAP
LA
I
LLIGP
I
G
I
WI
GSA
IS
ALVYT
I
HGYL
-
GWLSV
A
I
M
G
A
LW
PLL
VMTG
M
H
RVFT
P
TI
I
QTI
--
AET
G
fig|656379.3.peg.4072
Escherichia coli FVEC1302 (12-325/485)
V
I
AA
L
GG
V
D
NI
S
A
VT
HC
M
TRLRF
V
I
K
D
DQLIDSPT
L
K
TIS
GV
L
GV
VR
S
DN
Q
C
QV
I
IG
NT
V
SQ
-
---
A
FQEVV
S
LLPG
-
D
MQPAQPVGKPKLTLRRIGA
--
GI
L
DALIG
TM
S
PLIP
AI
I
GG
S
MV
K
-
LLA
M
I
--------
L
E
MSGVLTKG
S
P
T
----
L
T
I
L
NVI
GDG
A
F
F
FLP
L
M
V
AA
SA
AIK
F
KTN
MSL
A
IA
IA
GV
LV
---
HP
SFIELMAK
A
AQGEHV-
-
E
F
ALI
P
V
TAVK
Y
TYT
VIP
A
L
VMT
W
C
L
SY
IE
RW
V
DRIT
P
AVTKNFLK
P
M
LI
V
LI
AAP
LA
I
LLIGP
I
G
I
WI
GSA
IS
ALVYT
I
HGYL
-
GWLSV
A
I
M
G
A
LW
PLL
VMTG
M
H
RVFT
P
TI
I
QTI
--
AET
G
fig|656380.3.peg.3987
Escherichia coli FVEC1412 (12-325/485)
V
I
AA
L
GG
V
D
NI
S
A
VT
HC
M
TRLRF
V
I
K
D
DQLIDSPT
L
K
TIS
GV
L
GV
VR
S
DN
Q
C
QV
I
IG
NT
V
SQ
-
---
A
FQEVV
S
LLPG
-
D
MQPAQPVGKPKLTLRRIGA
--
GI
L
DALIG
TM
S
PLIP
AI
I
GG
S
MV
K
-
LLA
M
I
--------
L
E
MSGVLTKG
S
P
T
----
L
T
I
L
NVI
GDG
A
F
F
FLP
L
M
V
AA
SA
AIK
F
KTN
MSL
A
IA
IA
GV
LV
---
HP
SFIELMAK
A
AQGEHV-
-
E
F
ALI
P
V
TAVK
Y
TYT
VIP
A
L
VMT
W
C
L
SY
IE
RW
V
DRIT
P
AVTKNFLK
P
M
LI
V
LI
AAP
LA
I
LLIGP
I
G
I
WI
GSA
IS
ALVYT
I
HGYL
-
GWLSV
A
I
M
G
A
LW
PLL
VMTG
M
H
RVFT
P
TI
I
QTI
--
AET
G
fig|749549.3.peg.3787
Escherichia coli MS 198-1 (12-325/485)
V
I
AA
L
GG
V
D
NI
S
A
VT
HC
M
TRLRF
V
I
K
D
DQLIDSPT
L
K
TIS
GV
L
GV
VR
S
DN
Q
C
QV
I
IG
NT
V
SQ
-
---
A
FQEVV
S
LLPG
-
D
MQPAQPVGKPKLTLRRIGA
--
GI
L
DALIG
TM
S
PLIP
AI
I
GG
S
MV
K
-
LLA
M
I
--------
L
E
MSGVLTKG
S
P
T
----
L
T
I
L
NVI
GDG
A
F
F
FLP
L
M
V
AA
SA
AIK
F
KTN
MSL
A
IA
IA
GV
LV
---
HP
SFIELMAK
A
AQGEHV-
-
E
F
ALI
P
V
TAVK
Y
TYT
VIP
A
L
VMT
W
C
L
SY
IE
RW
V
DRIT
P
AVTKNFLK
P
M
LI
V
LI
AAP
LA
I
LLIGP
I
G
I
WI
GSA
IS
ALVYT
I
HGYL
-
GWLSV
A
I
M
G
A
LW
PLL
VMTG
M
H
RVFT
P
TI
I
QTI
--
AET
G
fig|585056.7.peg.3214
Escherichia coli UMN026 (12-325/485)
V
I
AA
L
GG
V
D
NI
S
A
VT
HC
M
TRLRF
V
I
K
D
DQLIDSPT
L
K
TIS
GV
L
GV
VR
S
DN
Q
C
QV
I
IG
NT
V
SQ
-
---
A
FQEVV
S
LLPG
-
D
MQPAQPVGKPKLTLRRIGA
--
GI
L
DALIG
TM
S
PLIP
AI
I
GG
S
MV
K
-
LLA
M
I
--------
L
E
MSGVLTKG
S
P
T
----
L
T
I
L
NVI
GDG
A
F
F
FLP
L
M
V
AA
SA
AIK
F
KTN
MSL
A
IA
IA
GV
LV
---
HP
SFIELMAK
A
AQGEHV-
-
E
F
ALI
P
V
TAVK
Y
TYT
VIP
A
L
VMT
W
C
L
SY
IE
RW
V
DRIT
P
AVTKNFLK
P
M
LI
V
LI
AAP
LA
I
LLIGP
I
G
I
WI
GSA
IS
ALVYT
I
HGYL
-
GWLSV
A
I
M
G
A
LW
PLL
VMTG
M
H
RVFT
P
TI
I
QTI
--
AET
G
fig|685038.3.peg.2706
Escherichia coli O83:H1 str. NRG 857C (12-325/485)
V
I
AA
L
GG
V
D
NI
S
A
VT
HC
M
TRLRF
V
I
K
D
DQLIDSPT
L
K
TIP
GV
L
GV
VR
S
DN
Q
C
QV
I
IG
NT
V
SQ
-
---
A
FQEVV
S
LLPG
-
D
MQPALPVGKPKLTLRRIGA
--
GI
L
DALIG
TM
S
PLIP
AI
I
GG
S
MV
K
-
LLA
M
I
--------
L
E
MSGVLTKG
S
P
T
----
L
T
I
L
NVI
GDG
A
F
F
FLP
L
M
V
AA
SA
AIK
F
KTN
MSL
A
IA
IA
GV
LV
---
HP
SFIELMAK
A
AQGEHV-
-
E
F
ALI
P
V
TAVK
Y
TYT
VIP
A
L
VMT
W
C
L
SY
IE
RW
V
DSIT
P
AVTKNFLK
P
M
LI
V
LI
AAP
LA
I
LLIGP
I
G
I
WI
GSA
IS
ALVYT
I
HGYL
-
GWLSV
A
I
M
G
A
LW
PLL
VMTG
M
H
RVFT
P
TI
I
QTI
--
AET
G
fig|216592.1.peg.3490
Escherichia coli 042 (12-325/485)
V
I
AA
L
GG
V
N
NI
S
A
VT
HC
M
TRLRF
V
I
K
D
DQLIDSPT
L
K
TIS
GV
L
GV
VR
S
DN
Q
C
QV
I
IG
NT
V
SH
-
---
A
FQEVV
S
LLPG
-
D
MQPAQPVGKPKLTLRRIGA
--
GI
L
DALIG
TM
S
PLIP
AI
I
GG
S
MV
K
-
LLA
M
I
--------
L
E
MSGVLTKG
S
P
T
----
L
T
I
L
NVI
GDG
A
F
F
FLP
L
M
V
AA
SA
AIK
F
KTN
MSQ
A
IA
IA
GV
LV
---
HP
SFIELMAK
A
AQGEHV-
-
E
F
ALI
P
V
TAVK
Y
TYT
VIP
A
L
VMT
W
C
L
SY
IE
RW
V
DRIT
P
AVTKNFLK
P
M
LI
V
LI
AAP
LA
I
LLIGP
I
G
I
WI
GSA
IS
ALVYT
I
HGYL
-
GWLSV
A
I
M
G
A
LW
PLL
VMTG
M
H
RVFT
P
TI
I
QTI
--
AET
G
fig|216592.3.peg.3039
Escherichia coli 042 (12-325/485)
V
I
AA
L
GG
V
N
NI
S
A
VT
HC
M
TRLRF
V
I
K
D
DQLIDSPT
L
K
TIS
GV
L
GV
VR
S
DN
Q
C
QV
I
IG
NT
V
SH
-
---
A
FQEVV
S
LLPG
-
D
MQPAQPVGKPKLTLRRIGA
--
GI
L
DALIG
TM
S
PLIP
AI
I
GG
S
MV
K
-
LLA
M
I
--------
L
E
MSGVLTKG
S
P
T
----
L
T
I
L
NVI
GDG
A
F
F
FLP
L
M
V
AA
SA
AIK
F
KTN
MSQ
A
IA
IA
GV
LV
---
HP
SFIELMAK
A
AQGEHV-
-
E
F
ALI
P
V
TAVK
Y
TYT
VIP
A
L
VMT
W
C
L
SY
IE
RW
V
DRIT
P
AVTKNFLK
P
M
LI
V
LI
AAP
LA
I
LLIGP
I
G
I
WI
GSA
IS
ALVYT
I
HGYL
-
GWLSV
A
I
M
G
A
LW
PLL
VMTG
M
H
RVFT
P
TI
I
QTI
--
AET
G
fig|656393.3.peg.3697
Escherichia coli H299 (12-325/485)
V
I
AA
L
GG
V
D
NI
S
A
VT
HC
M
TRLRF
V
I
K
D
DQLIDSPT
L
K
TIS
GV
L
GV
VR
S
DN
Q
C
QV
I
IG
NT
V
SQ
-
---
A
FQEVV
S
LLPG
-
D
MQPAQPVGKPKLTLRRIGA
--
GI
L
DALIG
TM
S
PLIP
AI
I
GG
S
MV
K
-
LLA
M
I
--------
L
E
MSGVLTKG
S
P
T
----
L
T
I
L
NVI
GDG
A
F
F
FLP
L
M
V
AA
SA
AIK
F
KTN
MSL
A
IA
IA
GV
LV
---
HP
SFIELMAK
A
AQGEHV-
-
E
F
ALI
P
V
TAVK
Y
TYT
VIP
A
L
VMT
W
C
L
SY
IE
RW
V
DSIT
P
AVTKNFLK
P
M
LI
V
LI
AAP
LA
I
LLIGP
I
G
I
WI
GSA
IS
ALVYT
I
HGYL
-
GWLSV
A
I
M
G
A
LW
PLL
VMTG
M
H
RVFT
P
TI
I
QTI
--
AET
G
fig|749531.3.peg.4971
Escherichia coli MS 69-1 (12-325/485)
V
I
AA
L
GG
V
D
NI
S
A
VT
HC
M
TRLRF
V
I
K
D
DQLIDSPT
L
K
TIS
GV
L
GV
VR
S
DN
Q
C
QV
I
IG
NT
V
SQ
-
---
A
FQEVV
S
LLPG
-
D
MQPAQPVGKPKLTLRRIGA
--
GI
L
DALIG
TM
S
PLIP
AI
I
GG
S
MV
K
-
LLA
M
I
--------
L
E
MSGVLTKG
S
P
T
----
L
T
I
L
NVI
GDG
A
F
F
FLP
L
M
V
AA
SA
AIK
F
KTN
MSL
A
IA
IA
GV
LV
---
HP
SFIELMAK
A
AQGEHV-
-
E
F
ALI
P
V
TAVK
Y
TYT
VIP
A
L
VMT
W
C
L
SY
IE
RW
V
DSIT
P
AVTKNFLK
P
M
LI
V
LI
AAP
LA
I
LLIGP
I
G
I
WI
GSA
IS
ALVYT
I
HGYL
-
GWLSV
A
I
M
G
A
LW
PLL
VMTG
M
H
RVFT
P
TI
I
QTI
--
AET
G
fig|656444.3.peg.3824
Escherichia coli TA280 (12-325/485)
V
I
AA
L
GG
V
D
NI
S
A
VT
HC
M
TRLRF
V
I
K
D
DQLIDSPT
L
K
TIS
GV
L
GV
VR
S
DN
Q
C
QV
I
IG
NT
V
SQ
-
---
A
FQEVV
S
LLPG
-
D
MQPAQPVGKPKLTLRRIGA
--
GI
L
DALIG
TM
S
PLIP
AI
I
GG
S
MV
K
-
LLA
M
I
--------
L
E
MSGVLTKG
S
P
T
----
L
T
I
L
NVI
GDG
A
F
F
FLP
L
M
V
AA
SA
AIK
F
KTN
MSL
A
IA
IA
GV
LV
---
HP
SFIELMAK
A
AQGEHV-
-
E
F
ALI
P
V
TAVK
Y
TYT
VIP
A
L
VMT
W
C
L
SY
IE
RW
V
DSIT
P
AVTKNFLK
P
M
LI
V
LI
AAP
LA
I
LLIGP
I
G
I
WI
GSA
IS
ALVYT
I
HGYL
-
GWLSV
A
I
M
G
A
LW
PLL
VMTG
M
H
RVFT
P
TI
I
QTI
--
AET
G
fig|358709.5.peg.3713
Escherichia coli 101-1 (12-325/485)
V
I
AA
L
GG
V
D
NI
S
A
VT
HC
M
TRLRF
V
I
K
D
DALIDSPT
L
K
TIS
GV
L
GV
VR
S
DN
Q
C
QV
I
IG
NT
V
SQ
-
---
A
FQEVV
S
LLPG
-
D
MQPALPVGKPKLTLRRIGA
--
GI
L
DALIG
TM
S
PLIP
AI
I
GG
S
MV
K
-
LLA
M
I
--------
L
E
MSGVLTKG
S
P
T
----
L
T
I
L
NVI
GDG
A
F
F
FLP
L
M
V
AA
SA
AIK
F
KTN
MSL
A
IA
IA
GV
LV
---
HP
SFIELMAK
A
AQGEHV-
-
E
F
ALI
P
V
TAVK
Y
TYT
VIP
A
L
VMT
W
C
L
SY
IE
RW
V
DSIT
P
AVTKNFLK
P
M
LI
V
LI
AAP
LA
I
LLIGP
I
G
I
WI
GSA
IS
ALVYT
I
HGYL
-
GWLSV
A
I
M
G
A
LW
PLL
VMTG
M
H
RVFT
P
TI
I
QTI
--
AET
G
fig|413997.3.peg.2689
Escherichia coli B str. REL606 (12-325/485)
V
I
AA
L
GG
V
D
NI
S
A
VT
HC
M
TRLRF
V
I
K
D
DALIDSPT
L
K
TIS
GV
L
GV
VR
S
DN
Q
C
QV
I
IG
NT
V
SQ
-
---
A
FQEVV
S
LLPG
-
D
MQPALPVGKPKLTLRRIGA
--
GI
L
DALIG
TM
S
PLIP
AI
I
GG
S
MV
K
-
LLA
M
I
--------
L
E
MSGVLTKG
S
P
T
----
L
T
I
L
NVI
GDG
A
F
F
FLP
L
M
V
AA
SA
AIK
F
KTN
MSL
A
IA
IA
GV
LV
---
HP
SFIELMAK
A
AQGEHV-
-
E
F
ALI
P
V
TAVK
Y
TYT
VIP
A
L
VMT
W
C
L
SY
IE
RW
V
DSIT
P
AVTKNFLK
P
M
LI
V
LI
AAP
LA
I
LLIGP
I
G
I
WI
GSA
IS
ALVYT
I
HGYL
-
GWLSV
A
I
M
G
A
LW
PLL
VMTG
M
H
RVFT
P
TI
I
QTI
--
AET
G
fig|511693.5.peg.2706
Escherichia coli BL21 (12-325/485)
V
I
AA
L
GG
V
D
NI
S
A
VT
HC
M
TRLRF
V
I
K
D
DALIDSPT
L
K
TIS
GV
L
GV
VR
S
DN
Q
C
QV
I
IG
NT
V
SQ
-
---
A
FQEVV
S
LLPG
-
D
MQPALPVGKPKLTLRRIGA
--
GI
L
DALIG
TM
S
PLIP
AI
I
GG
S
MV
K
-
LLA
M
I
--------
L
E
MSGVLTKG
S
P
T
----
L
T
I
L
NVI
GDG
A
F
F
FLP
L
M
V
AA
SA
AIK
F
KTN
MSL
A
IA
IA
GV
LV
---
HP
SFIELMAK
A
AQGEHV-
-
E
F
ALI
P
V
TAVK
Y
TYT
VIP
A
L
VMT
W
C
L
SY
IE
RW
V
DSIT
P
AVTKNFLK
P
M
LI
V
LI
AAP
LA
I
LLIGP
I
G
I
WI
GSA
IS
ALVYT
I
HGYL
-
GWLSV
A
I
M
G
A
LW
PLL
VMTG
M
H
RVFT
P
TI
I
QTI
--
AET
G
fig|469008.4.peg.1033
Escherichia coli BL21(DE3) (12-325/485)
V
I
AA
L
GG
V
D
NI
S
A
VT
HC
M
TRLRF
V
I
K
D
DALIDSPT
L
K
TIS
GV
L
GV
VR
S
DN
Q
C
QV
I
IG
NT
V
SQ
-
---
A
FQEVV
S
LLPG
-
D
MQPALPVGKPKLTLRRIGA
--
GI
L
DALIG
TM
S
PLIP
AI
I
GG
S
MV
K
-
LLA
M
I
--------
L
E
MSGVLTKG
S
P
T
----
L
T
I
L
NVI
GDG
A
F
F
FLP
L
M
V
AA
SA
AIK
F
KTN
MSL
A
IA
IA
GV
LV
---
HP
SFIELMAK
A
AQGEHV-
-
E
F
ALI
P
V
TAVK
Y
TYT
VIP
A
L
VMT
W
C
L
SY
IE
RW
V
DSIT
P
AVTKNFLK
P
M
LI
V
LI
AAP
LA
I
LLIGP
I
G
I
WI
GSA
IS
ALVYT
I
HGYL
-
GWLSV
A
I
M
G
A
LW
PLL
VMTG
M
H
RVFT
P
TI
I
QTI
--
AET
G
fig|749547.3.peg.2750
Escherichia coli MS 187-1 (12-325/485)
V
I
AA
L
GG
V
D
NI
S
A
VT
HC
M
TRLRF
V
I
K
D
DALIDSPT
L
K
TIS
GV
L
GV
VR
S
DN
Q
C
QV
I
IG
NT
V
SQ
-
---
A
FQEVV
S
LLPG
-
D
MQPALPVGKPKLTLRRIGA
--
GI
L
DALIG
TM
S
PLIP
AI
I
GG
S
MV
K
-
LLA
M
I
--------
L
E
MSGVLTKG
S
P
T
----
L
T
I
L
NVI
GDG
A
F
F
FLP
L
M
V
AA
SA
AIK
F
KTN
MSL
A
IA
IA
GV
LV
---
HP
SFIELMAK
A
AQGEHV-
-
E
F
ALI
P
V
TAVK
Y
TYT
VIP
A
L
VMT
W
C
L
SY
IE
RW
V
DSIT
P
AVTKNFLK
P
M
LI
V
LI
AAP
LA
I
LLIGP
I
G
I
WI
GSA
IS
ALVYT
I
HGYL
-
GWLSV
A
I
M
G
A
LW
PLL
VMTG
M
H
RVFT
P
TI
I
QTI
--
AET
G
fig|637912.3.peg.2724
Escherichia coli OP50 (12-325/485)
V
I
AA
L
GG
V
D
NI
S
A
VT
HC
M
TRLRF
V
I
K
D
DALIDSPT
L
K
TIS
GV
L
GV
VR
S
DN
Q
C
QV
I
IG
NT
V
SQ
-
---
A
FQEVV
S
LLPG
-
D
MQPALPVGKPKLTLRRIGA
--
GI
L
DALIG
TM
S
PLIP
AI
I
GG
S
MV
K
-
LLA
M
I
--------
L
E
MSGVLTKG
S
P
T
----
L
T
I
L
NVI
GDG
A
F
F
FLP
L
M
V
AA
SA
AIK
F
KTN
MSL
A
IA
IA
GV
LV
---
HP
SFIELMAK
A
AQGEHV-
-
E
F
ALI
P
V
TAVK
Y
TYT
VIP
A
L
VMT
W
C
L
SY
IE
RW
V
DSIT
P
AVTKNFLK
P
M
LI
V
LI
AAP
LA
I
LLIGP
I
G
I
WI
GSA
IS
ALVYT
I
HGYL
-
GWLSV
A
I
M
G
A
LW
PLL
VMTG
M
H
RVFT
P
TI
I
QTI
--
AET
G
fig|749527.3.peg.5326
Escherichia coli MS 21-1 (12-325/485)
V
I
AA
L
GG
V
D
NI
S
A
VT
HC
M
TRLRF
V
I
K
D
DQLIDSPT
L
K
TIS
GV
L
GV
VR
S
DN
Q
C
QV
I
IG
NT
V
SQ
-
---
A
FQEVV
S
LLPG
-
D
MQPAQPVGKPKLTLRRIGA
--
GI
L
DALIG
TM
S
PLIP
AI
I
GG
S
MV
K
-
LLA
M
I
--------
L
E
MSGVLTKG
S
P
T
----
L
T
I
L
NVI
GDG
A
F
F
FLP
L
M
V
AA
SA
AIK
F
KTN
MSL
A
IA
IA
GV
LV
---
HP
SFIELMAK
A
AQGEHV-
-
E
F
ALI
P
V
TAVK
Y
TYT
VIP
A
L
VMT
W
C
L
SY
IE
RW
V
DSIT
P
AVTKNFLK
P
M
LI
V
LI
AAP
LA
I
LLIGP
I
G
I
WI
GSA
IS
ALVYT
I
HGYL
-
GWLSV
A
I
M
G
A
LW
PLL
VMTG
M
H
RVFT
P
TI
I
QTI
--
AET
G
fig|83333.1.peg.2670
Escherichia coli K12 (12-325/485)
V
I
AA
L
GG
V
D
NI
S
A
VT
HC
M
TRLRF
V
I
K
D
DALIDSPT
L
K
TIP
GV
L
GV
VR
S
DN
Q
C
QV
I
IG
NT
V
SQ
-
---
A
FQEVV
S
LLPG
-
D
MQPAQPVGKPKLTLRRIGA
--
GI
L
DALIG
TM
S
PLIP
AI
I
GG
S
MV
K
-
LLA
M
I
--------
L
E
MSGVLTKG
S
P
T
----
L
T
I
L
NVI
GDG
A
F
F
FLP
L
M
V
AH
LP
RIK
F
KTN
MSL
A
IA
IA
GV
LV
---
HP
SFIELMAK
A
AQGEHV-
-
E
F
ALI
P
V
TAVK
Y
TYT
VIP
A
L
VMT
W
C
L
SY
IE
RW
V
DSIT
P
AVTKNFLK
P
M
LI
V
LI
AAP
LA
I
LLIGP
I
G
I
WI
GSA
IS
ALVYT
I
HGYL
-
GWLSV
A
I
M
G
A
LW
PLL
VMTG
M
H
RVFT
P
TI
I
QTI
--
AET
G
fig|405955.13.peg.3022
Escherichia coli APEC O1 (12-325/485)
V
I
TA
L
GG
V
D
NI
S
A
VT
HC
M
TRLRF
V
I
K
D
DQLIDSPT
L
K
TIS
GV
L
GV
VR
S
DN
Q
C
QV
I
IG
NT
V
SQ
-
---
A
FQEVV
S
LLPG
-
D
LQPAPPVGKPKLTLRRIGA
--
GV
L
DALIG
TM
S
PLIP
AI
I
GG
S
MV
K
-
LLA
M
I
--------
L
E
MSGVLTKG
S
P
T
----
L
I
I
L
NVI
GDG
A
F
F
FLP
L
M
V
AA
SA
AIK
F
KTN
MSL
A
IA
IA
GV
LV
---
HP
SFIELMAK
A
ALGEHV-
-
E
F
ALI
P
V
TAVK
Y
TYT
VIP
A
L
VMT
W
C
L
SY
IE
RW
V
DSIT
P
AVTKNFLK
P
M
LI
V
LI
AAP
LA
I
LLIGP
I
G
I
WI
GSA
IS
ALVYT
I
HGYL
-
GWLSV
A
I
M
G
A
LW
PLL
VMTG
M
H
RVFT
P
TI
I
QTI
--
AET
G
fig|405955.9.peg.2495
Escherichia coli APEC O1 (12-325/485)
V
I
TA
L
GG
V
D
NI
S
A
VT
HC
M
TRLRF
V
I
K
D
DQLIDSPT
L
K
TIS
GV
L
GV
VR
S
DN
Q
C
QV
I
IG
NT
V
SQ
-
---
A
FQEVV
S
LLPG
-
D
LQPAPPVGKPKLTLRRIGA
--
GV
L
DALIG
TM
S
PLIP
AI
I
GG
S
MV
K
-
LLA
M
I
--------
L
E
MSGVLTKG
S
P
T
----
L
I
I
L
NVI
GDG
A
F
F
FLP
L
M
V
AA
SA
AIK
F
KTN
MSL
A
IA
IA
GV
LV
---
HP
SFIELMAK
A
ALGEHV-
-
E
F
ALI
P
V
TAVK
Y
TYT
VIP
A
L
VMT
W
C
L
SY
IE
RW
V
DSIT
P
AVTKNFLK
P
M
LI
V
LI
AAP
LA
I
LLIGP
I
G
I
WI
GSA
IS
ALVYT
I
HGYL
-
GWLSV
A
I
M
G
A
LW
PLL
VMTG
M
H
RVFT
P
TI
I
QTI
--
AET
G
fig|714962.3.peg.3125
Escherichia coli IHE3034 (12-325/485)
V
I
TA
L
GG
V
D
NI
S
A
VT
HC
M
TRLRF
V
I
K
D
DQLIDSPT
L
K
TIS
GV
L
GV
VR
S
DN
Q
C
QV
I
IG
NT
V
SQ
-
---
A
FQEVV
S
LLPG
-
D
LQPAPPVGKPKLTLRRIGA
--
GV
L
DALIG
TM
S
PLIP
AI
I
GG
S
MV
K
-
LLA
M
I
--------
L
E
MSGVLTKG
S
P
T
----
L
I
I
L
NVI
GDG
A
F
F
FLP
L
M
V
AA
SA
AIK
F
KTN
MSL
A
IA
IA
GV
LV
---
HP
SFIELMAK
A
ALGEHV-
-
E
F
ALI
P
V
TAVK
Y
TYT
VIP
A
L
VMT
W
C
L
SY
IE
RW
V
DSIT
P
AVTKNFLK
P
M
LI
V
LI
AAP
LA
I
LLIGP
I
G
I
WI
GSA
IS
ALVYT
I
HGYL
-
GWLSV
A
I
M
G
A
LW
PLL
VMTG
M
H
RVFT
P
TI
I
QTI
--
AET
G
fig|585035.6.peg.2923
Escherichia coli S88 (12-325/485)
V
I
TA
L
GG
V
D
NI
S
A
VT
HC
M
TRLRF
V
I
K
D
DQLIDSPT
L
K
TIS
GV
L
GV
VR
S
DN
Q
C
QV
I
IG
NT
V
SQ
-
---
A
FQEVV
S
LLPG
-
D
LQPAPPVGKPKLTLRRIGA
--
GV
L
DALIG
TM
S
PLIP
AI
I
GG
S
MV
K
-
LLA
M
I
--------
L
E
MSGVLTKG
S
P
T
----
L
I
I
L
NVI
GDG
A
F
F
FLP
L
M
V
AA
SA
AIK
F
KTN
MSL
A
IA
IA
GV
LV
---
HP
SFIELMAK
A
ALGEHV-
-
E
F
ALI
P
V
TAVK
Y
TYT
VIP
A
L
VMT
W
C
L
SY
IE
RW
V
DSIT
P
AVTKNFLK
P
M
LI
V
LI
AAP
LA
I
LLIGP
I
G
I
WI
GSA
IS
ALVYT
I
HGYL
-
GWLSV
A
I
M
G
A
LW
PLL
VMTG
M
H
RVFT
P
TI
I
QTI
--
AET
G
fig|869729.3.peg.653
Escherichia coli UM146 (12-325/485)
V
I
TA
L
GG
V
D
NI
S
A
VT
HC
M
TRLRF
V
I
K
D
DQLIDSPT
L
K
TIS
GV
L
GV
VR
S
DN
Q
C
QV
I
IG
NT
V
SQ
-
---
A
FQEVV
S
LLPG
-
D
LQPAPPVGKPKLTLRRIGA
--
GV
L
DALIG
TM
S
PLIP
AI
I
GG
S
MV
K
-
LLA
M
I
--------
L
E
MSGVLTKG
S
P
T
----
L
I
I
L
NVI
GDG
A
F
F
FLP
L
M
V
AA
SA
AIK
F
KTN
MSL
A
IA
IA
GV
LV
---
HP
SFIELMAK
A
ALGEHV-
-
E
F
ALI
P
V
TAVK
Y
TYT
VIP
A
L
VMT
W
C
L
SY
IE
RW
V
DSIT
P
AVTKNFLK
P
M
LI
V
LI
AAP
LA
I
LLIGP
I
G
I
WI
GSA
IS
ALVYT
I
HGYL
-
GWLSV
A
I
M
G
A
LW
PLL
VMTG
M
H
RVFT
P
TI
I
QTI
--
AET
G
fig|364106.7.peg.3058
Escherichia coli UTI89 (12-325/485)
V
I
TA
L
GG
V
D
NI
S
A
VT
HC
M
TRLRF
V
I
K
D
DQLIDSPT
L
K
TIS
GV
L
GV
VR
S
DN
Q
C
QV
I
IG
NT
V
SQ
-
---
A
FQEVV
S
LLPG
-
D
LQPAPPVGKPKLTLRRIGA
--
GV
L
DALIG
TM
S
PLIP
AI
I
GG
S
MV
K
-
LLA
M
I
--------
L
E
MSGVLTKG
S
P
T
----
L
I
I
L
NVI
GDG
A
F
F
FLP
L
M
V
AA
SA
AIK
F
KTN
MSL
A
IA
IA
GV
LV
---
HP
SFIELMAK
A
ALGEHV-
-
E
F
ALI
P
V
TAVK
Y
TYT
VIP
A
L
VMT
W
C
L
SY
IE
RW
V
DSIT
P
AVTKNFLK
P
M
LI
V
LI
AAP
LA
I
LLIGP
I
G
I
WI
GSA
IS
ALVYT
I
HGYL
-
GWLSV
A
I
M
G
A
LW
PLL
VMTG
M
H
RVFT
P
TI
I
QTI
--
AET
G
fig|364106.8.peg.3059
Escherichia coli UTI89 (12-325/485)
V
I
TA
L
GG
V
D
NI
S
A
VT
HC
M
TRLRF
V
I
K
D
DQLIDSPT
L
K
TIS
GV
L
GV
VR
S
DN
Q
C
QV
I
IG
NT
V
SQ
-
---
A
FQEVV
S
LLPG
-
D
LQPAPPVGKPKLTLRRIGA
--
GV
L
DALIG
TM
S
PLIP
AI
I
GG
S
MV
K
-
LLA
M
I
--------
L
E
MSGVLTKG
S
P
T
----
L
I
I
L
NVI
GDG
A
F
F
FLP
L
M
V
AA
SA
AIK
F
KTN
MSL
A
IA
IA
GV
LV
---
HP
SFIELMAK
A
ALGEHV-
-
E
F
ALI
P
V
TAVK
Y
TYT
VIP
A
L
VMT
W
C
L
SY
IE
RW
V
DSIT
P
AVTKNFLK
P
M
LI
V
LI
AAP
LA
I
LLIGP
I
G
I
WI
GSA
IS
ALVYT
I
HGYL
-
GWLSV
A
I
M
G
A
LW
PLL
VMTG
M
H
RVFT
P
TI
I
QTI
--
AET
G
fig|753642.3.peg.443
Escherichia coli NC101 (12-325/485)
V
I
TA
L
GG
V
D
NI
S
A
VT
HC
M
TRLRF
V
I
K
D
DQLIDSPT
L
K
TIS
GV
L
GV
VR
S
DN
Q
C
QV
I
IG
NT
V
SL
-
---
A
FQEVV
S
LLPG
-
D
MQPAQPVGKPKLTLRRIGA
--
GI
L
DALIG
TM
S
PLIP
AI
I
GG
S
MV
K
-
LLA
ML
--------
L
E
MSGVLTKG
S
P
T
----
L
T
I
L
NVI
GDG
A
F
F
FLP
L
M
V
AA
SA
AIK
F
KTN
MSL
A
IA
IA
GV
LV
---
HP
SFIELMAK
A
AQGEHV-
-
E
F
ALI
P
V
TAVK
Y
TYT
VIP
A
L
VMT
W
C
L
SY
IE
RW
V
DSIT
P
AVTKNFLK
P
M
LI
V
LI
AAP
LA
I
LLIGP
I
G
I
WI
GSA
IS
ALVYT
I
HGYL
-
GWLSV
A
I
M
G
A
LW
PLL
VMTG
M
H
RVFT
P
TI
I
QTI
--
AET
G
fig|362663.8.peg.2711
Escherichia coli 536 (12-325/485)
V
I
TA
L
GG
V
D
NI
S
A
VT
HC
M
TRLRF
V
I
K
D
DQLIDSPT
L
K
TIS
GV
L
GV
VR
S
DN
Q
C
QV
I
IG
NT
V
SL
-
---
A
FQEVV
S
LLPG
-
D
MQPAQPVGKPKLTLRRIGA
--
GI
L
DALIG
TM
S
PLIP
AI
I
CG
S
MV
K
-
LLA
M
I
--------
L
E
MSGVLTKG
S
P
T
----
L
I
I
L
NVI
GDG
A
F
F
FLP
L
M
V
AA
SA
AIK
F
KTN
MSL
A
IA
IA
GV
LV
---
HP
SFIELMAK
A
AQGEHV-
-
E
F
ALI
P
V
TAVK
Y
TYT
VIP
A
L
VMT
W
C
L
SY
IE
RW
V
DSIT
P
AVTKNFLK
P
M
LI
V
LI
AAP
LA
I
LLIGP
I
G
I
WI
GSA
IS
ALVYT
I
HGYL
-
GWLSV
A
I
M
G
A
LW
PLL
VMTG
M
H
RVFT
P
TI
I
QTI
--
AET
G
fig|362663.9.peg.2716
Escherichia coli 536 (12-325/485)
V
I
TA
L
GG
V
D
NI
S
A
VT
HC
M
TRLRF
V
I
K
D
DQLIDSPT
L
K
TIS
GV
L
GV
VR
S
DN
Q
C
QV
I
IG
NT
V
SL
-
---
A
FQEVV
S
LLPG
-
D
MQPAQPVGKPKLTLRRIGA
--
GI
L
DALIG
TM
S
PLIP
AI
I
CG
S
MV
K
-
LLA
M
I
--------
L
E
MSGVLTKG
S
P
T
----
L
I
I
L
NVI
GDG
A
F
F
FLP
L
M
V
AA
SA
AIK
F
KTN
MSL
A
IA
IA
GV
LV
---
HP
SFIELMAK
A
AQGEHV-
-
E
F
ALI
P
V
TAVK
Y
TYT
VIP
A
L
VMT
W
C
L
SY
IE
RW
V
DSIT
P
AVTKNFLK
P
M
LI
V
LI
AAP
LA
I
LLIGP
I
G
I
WI
GSA
IS
ALVYT
I
HGYL
-
GWLSV
A
I
M
G
A
LW
PLL
VMTG
M
H
RVFT
P
TI
I
QTI
--
AET
G
fig|340197.3.peg.1470
Escherichia coli F11 (12-325/485)
V
I
TA
L
GG
V
D
NI
S
A
VT
HC
M
TRLRF
V
I
K
D
DQLIDSPT
L
K
TIS
GV
L
GV
VR
S
DN
Q
C
QV
I
IG
NT
V
SL
-
---
A
FQEVV
S
LLPG
-
D
MQPAQPVGKPKLTLRRIGA
--
GI
L
DALIG
TM
S
PLIP
AI
I
CG
S
MV
K
-
LLA
M
I
--------
L
E
MSGVLTKG
S
P
T
----
L
I
I
L
NVI
GDG
A
F
F
FLP
L
M
V
AA
SA
AIK
F
KTN
MSL
A
IA
IA
GV
LV
---
HP
SFIELMAK
A
AQGEHV-
-
E
F
ALI
P
V
TAVK
Y
TYT
VIP
A
L
VMT
W
C
L
SY
IE
RW
V
DSIT
P
AVTKNFLK
P
M
LI
V
LI
AAP
LA
I
LLIGP
I
G
I
WI
GSA
IS
ALVYT
I
HGYL
-
GWLSV
A
I
M
G
A
LW
PLL
VMTG
M
H
RVFT
P
TI
I
QTI
--
AET
G
fig|340197.5.peg.1555
Escherichia coli F11 (12-325/485)
V
I
TA
L
GG
V
D
NI
S
A
VT
HC
M
TRLRF
V
I
K
D
DQLIDSPT
L
K
TIS
GV
L
GV
VR
S
DN
Q
C
QV
I
IG
NT
V
SL
-
---
A
FQEVV
S
LLPG
-
D
MQPAQPVGKPKLTLRRIGA
--
GI
L
DALIG
TM
S
PLIP
AI
I
CG
S
MV
K
-
LLA
M
I
--------
L
E
MSGVLTKG
S
P
T
----
L
I
I
L
NVI
GDG
A
F
F
FLP
L
M
V
AA
SA
AIK
F
KTN
MSL
A
IA
IA
GV
LV
---
HP
SFIELMAK
A
AQGEHV-
-
E
F
ALI
P
V
TAVK
Y
TYT
VIP
A
L
VMT
W
C
L
SY
IE
RW
V
DSIT
P
AVTKNFLK
P
M
LI
V
LI
AAP
LA
I
LLIGP
I
G
I
WI
GSA
IS
ALVYT
I
HGYL
-
GWLSV
A
I
M
G
A
LW
PLL
VMTG
M
H
RVFT
P
TI
I
QTI
--
AET
G
fig|749550.3.peg.508
Escherichia coli MS 200-1 (12-325/485)
V
I
TA
L
GG
V
D
NI
S
A
VT
HC
M
TRLRF
V
I
K
D
DQLIDSPT
L
K
TIS
GV
L
GV
VR
S
DN
Q
C
QV
I
IG
NT
V
SL
-
---
A
FQEVV
S
LLPG
-
D
MQPAQPVGKPKLTLRRIGA
--
GI
L
DALIG
TM
S
PLIP
AI
I
CG
S
MV
K
-
LLA
M
I
--------
L
E
MSGVLTKG
S
P
T
----
L
I
I
L
NVI
GDG
A
F
F
FLP
L
M
V
AA
SA
AIK
F
KTN
MSL
A
IA
IA
GV
LV
---
HP
SFIELMAK
A
AQGEHV-
-
E
F
ALI
P
V
TAVK
Y
TYT
VIP
A
L
VMT
W
C
L
SY
IE
RW
V
DSIT
P
AVTKNFLK
P
M
LI
V
LI
AAP
LA
I
LLIGP
I
G
I
WI
GSA
IS
ALVYT
I
HGYL
-
GWLSV
A
I
M
G
A
LW
PLL
VMTG
M
H
RVFT
P
TI
I
QTI
--
AET
G
fig|439855.10.peg.2992
Escherichia coli SMS-3-5 (12-325/485)
V
I
AA
L
GG
V
D
NI
S
A
VT
HC
M
TRLRF
V
I
K
D
DQLIDSPT
L
K
TIS
GV
L
GV
VR
S
DN
Q
C
QV
I
IG
NT
V
SQ
-
---
A
FQEVV
S
LLPG
-
D
MQPAQPEGKPKLTLRRIGA
--
GI
L
DALIG
TM
S
PLIP
AI
I
GG
S
MV
K
-
LLA
M
I
--------
L
E
MSGVLTKG
S
P
T
----
L
T
I
L
NVI
GDG
A
F
F
FLP
L
M
V
AA
SA
AIK
F
KTN
MSL
A
IA
IA
GV
LV
---
HP
SFIELMAK
A
AQGEHV-
-
E
F
ALI
P
V
TAVK
Y
TYT
VIP
A
L
VMT
W
C
L
SY
IE
RW
V
DSIT
P
AVTKNFLK
P
M
LI
V
LI
AAP
LA
I
LLIGP
I
G
I
WI
GSA
IS
ALVYT
I
HGYL
-
GWLSV
A
I
M
G
A
LW
PLL
VMTG
M
H
RVFT
P
TI
I
QTI
--
AET
G
Consen1
Primary consensus
MakeIsselln
ii
vGG
gNI
s
hC
TRLRf
l
d
ik
gv
gv
s
Q
QVviG
v
-
A
g
-
d
--
l
if
PLip
i
glllg
li
--------
t
q
t
----
l
fl
gdg
F
flpi
v
sA
fggt
g
ia
lv
---
hP
g
-
dF
pi
y
vIp
l
w
l
iE
v
P
pl
lli
la
lligP
g
wi
is
l
-
Av
g
lw
VmtGvH
p
l
--
G
l
Pll
a
aQG
Consen2
Secondary consensus
msk
nqtdid
l
d
n
l
q
le
mi
mc
if
k
r
s
q
-
vq
tm
lg
a
s
k
-
agdlpmsng
e
s
ilpday
im
s
a
yfv
mktn
a
lg
fllgy
a
le
sv
p
i
g
i
l
c
l
l
s
v
vt
aivm
s
ml
a
i
f
a
f
f
a
i
ii
s
g
Consensus 1
(when a gap)
Conservative difference
Consensus 2
(when a gap)
Nonconservative diff.
Other character