fig|1040638.4.peg.827
Escherichia coli O104:H4 str. LB226692
MNKIYSLKYS
HI
TGGL
V
AVSEL
T
R
K
V
SVG
T
S
R
KK
---
-
---
VILGIILSSI-YGSYGETAF
A
A
M
L
DINNI
W
T
RDY
L
D
L
AQN
R
G
E
F
RP
GATN
V
Q
L
MM
K
D
G
KIF
-
H
F
PEL
P
VP
DFS
A
V
S
--
N
----
K
G
A
T
T
S
IGG
A
Y
SV
TA
T
HN
G
TQ
HH
A
IT
TQ
SWD
Q
T
A
Y
KAS
N
-
R
VSS
--
G
DF
SVH
RL
N
K
F
VVET
T
G
VTESADFSL
S
PED
A
MK
RYG
VNY-NGK
E
QIIG
FRAG
A
G
TT
S
TILN-
--
-----
-
-
-
-
---
G
KQYLFGQN-YNP
D
L
L
S
-
A
S
LFN
L
-DWKNKS
-----
YIYT
N
R
-
TP
F
K
N
SPIF
GDSGS
GS
Y
L
YD
K
EQQ
KWV
F
H
G
V
T
S
TV
--
G
FIS-S
T
NIAW
T
NYSLF
N
NILV
N
N
LK
KNFTNTM
Q
---
----
-
-
-
-
-
L
D
G
-KKQELS
S
-
-
--
---------
-
-IIK
----
D---
-
KDL
S
V
S
G
G
-
G
V
L
T
LK
QD
TDL
G
I
G
G
L
I
F
D
K
NQT
Y
K
V
YGKD
--
-K
SY
KGAGID
IDNNTT
VEWN
VK
G
VAG
DNLHKIG
S
GTL
D
V
KIA
--
Q
GN
NLK
I
G
N
G
T
VIL
SA
E
--
--
-
-
-
K
A
FN
K
I
Y
M
A
G
G
K
GTV
K
I
N
AKDA
L
S
E
SGN
G
E
-
I
Y
F
TR
NGG
T
LDLNGY
D
Q
S
F
Q
KIAATD
A
G
T
T
V
TNS
-
NV
K
Q
S
T
LSL
T
-
------------------------------------------------------------------
----
-
----
-------
N
TDA
Y
M
YHG
N
V
S
GN
I
SINH
IIN
TTQQ--HNNNAN
LI
F
DG
S
VD
I
-
K
N
DISVR
N
AQ
L
T
L
QGHAT
E
HA
IFKEG-NNNCPIP----
FLC
Q
K
D
Y
S
AAIKDQ
E
STVN
K
RYNTEY
K
S
NNQ
I
A
SF
S
Q
P
DWE
S
R
K
F
N
F
RK
L
N
L
E
N
A
T
L
S
I
G
R
D
A
N
V
K
G
H
I
E
A
-
KN
S
Q
I
V
L
G
--
N
KT
AYID
MFS
G
R
NIT
G
E
G
F
G
FRQQLRS
G
D
S
A
--
---
GE
S
S
F
N
G
S
LS
A
Q
NS
K
N
NCW
fig|585055.6.peg.4704
Escherichia coli 55989 (1-697/1285)
MNKIYSLKYS
HI
TGGL
V
AVSEL
T
R
K
V
SVG
T
S
R
KK
---
-
---
VILGIILSSI-YGSYGETAF
A
A
M
L
DINNI
W
T
RDY
L
D
L
AQN
R
G
E
F
RP
GATN
V
Q
L
MM
K
D
G
KIF
-
H
F
PEL
P
VP
DFS
A
V
S
--
N
----
K
G
A
T
T
S
IGG
A
Y
SV
TA
T
HN
G
TQ
HH
A
IT
TQ
SWD
Q
T
A
Y
KAS
N
-
R
VSS
--
G
DF
SVH
RL
N
K
F
VVET
T
G
VTESADFSL
S
PED
A
MK
RYG
VNY-NGK
E
QIIG
FRAG
A
G
TT
S
TILN-
--
-----
-
-
-
-
---
G
KQYLFGQN-YNP
D
L
L
S
-
A
S
LFN
L
-DWKNKS
-----
YIYT
N
R
-
TP
F
K
N
SPIF
GDSGS
GS
Y
L
YD
K
EQQ
KWV
F
H
G
V
T
S
TV
--
G
FIS-S
T
NIAW
T
NYSLF
N
NILV
N
N
LK
KNFTNTM
Q
---
----
-
-
-
-
-
L
D
G
-KKQELS
S
-
-
--
---------
-
-IIK
----
D---
-
KDL
S
V
S
G
G
-
G
V
L
T
LK
QD
TDL
G
I
G
G
L
I
F
D
K
NQT
Y
K
V
YGKD
--
-K
SY
KGAGID
IDNNTT
VEWN
VK
G
VAG
DNLHKIG
S
GTL
D
V
KIA
--
Q
GN
NLK
I
G
N
G
T
VIL
SA
E
--
--
-
-
-
K
A
FN
K
I
Y
M
A
G
G
K
GTV
K
I
N
AKDA
L
S
E
SGN
G
E
-
I
Y
F
TR
NGG
T
LDLNGY
D
Q
S
F
Q
KIAATD
A
G
T
T
V
TNS
-
NV
K
Q
S
T
LSL
T
-
------------------------------------------------------------------
----
-
----
-------
N
TDA
Y
M
YHG
N
V
S
GN
I
SINH
IIN
TTQQ--HNNNAN
LI
F
DG
S
VD
I
-
K
N
DISVR
N
AQ
L
T
L
QGHAT
E
HA
IFKEG-NNNCPIP----
FLC
Q
K
D
Y
S
AAIKDQ
E
STVN
K
RYNTEY
K
S
NNQ
I
A
SF
S
Q
P
DWE
S
R
K
F
N
F
RK
L
N
L
E
N
A
T
L
S
I
G
R
D
A
N
V
K
G
H
I
E
A
-
KN
S
Q
I
V
L
G
--
N
KT
AYID
MFS
G
R
NIT
G
E
G
F
G
FRQQLRS
G
D
S
A
--
---
GE
S
S
F
N
G
S
LS
A
Q
NS
K
fig|585055.8.peg.4709
Escherichia coli 55989 (1-697/1285)
MNKIYSLKYS
HI
TGGL
V
AVSEL
T
R
K
V
SVG
T
S
R
KK
---
-
---
VILGIILSSI-YGSYGETAF
A
A
M
L
DINNI
W
T
RDY
L
D
L
AQN
R
G
E
F
RP
GATN
V
Q
L
MM
K
D
G
KIF
-
H
F
PEL
P
VP
DFS
A
V
S
--
N
----
K
G
A
T
T
S
IGG
A
Y
SV
TA
T
HN
G
TQ
HH
A
IT
TQ
SWD
Q
T
A
Y
KAS
N
-
R
VSS
--
G
DF
SVH
RL
N
K
F
VVET
T
G
VTESADFSL
S
PED
A
MK
RYG
VNY-NGK
E
QIIG
FRAG
A
G
TT
S
TILN-
--
-----
-
-
-
-
---
G
KQYLFGQN-YNP
D
L
L
S
-
A
S
LFN
L
-DWKNKS
-----
YIYT
N
R
-
TP
F
K
N
SPIF
GDSGS
GS
Y
L
YD
K
EQQ
KWV
F
H
G
V
T
S
TV
--
G
FIS-S
T
NIAW
T
NYSLF
N
NILV
N
N
LK
KNFTNTM
Q
---
----
-
-
-
-
-
L
D
G
-KKQELS
S
-
-
--
---------
-
-IIK
----
D---
-
KDL
S
V
S
G
G
-
G
V
L
T
LK
QD
TDL
G
I
G
G
L
I
F
D
K
NQT
Y
K
V
YGKD
--
-K
SY
KGAGID
IDNNTT
VEWN
VK
G
VAG
DNLHKIG
S
GTL
D
V
KIA
--
Q
GN
NLK
I
G
N
G
T
VIL
SA
E
--
--
-
-
-
K
A
FN
K
I
Y
M
A
G
G
K
GTV
K
I
N
AKDA
L
S
E
SGN
G
E
-
I
Y
F
TR
NGG
T
LDLNGY
D
Q
S
F
Q
KIAATD
A
G
T
T
V
TNS
-
NV
K
Q
S
T
LSL
T
-
------------------------------------------------------------------
----
-
----
-------
N
TDA
Y
M
YHG
N
V
S
GN
I
SINH
IIN
TTQQ--HNNNAN
LI
F
DG
S
VD
I
-
K
N
DISVR
N
AQ
L
T
L
QGHAT
E
HA
IFKEG-NNNCPIP----
FLC
Q
K
D
Y
S
AAIKDQ
E
STVN
K
RYNTEY
K
S
NNQ
I
A
SF
S
Q
P
DWE
S
R
K
F
N
F
RK
L
N
L
E
N
A
T
L
S
I
G
R
D
A
N
V
K
G
H
I
E
A
-
KN
S
Q
I
V
L
G
--
N
KT
AYID
MFS
G
R
NIT
G
E
G
F
G
FRQQLRS
G
D
S
A
--
---
GE
S
S
F
N
G
S
LS
A
Q
NS
K
fig|216593.1.peg.985
Escherichia coli E2348/69 (4-712/1308)
MNKIY
A
LKY
C
HA
TGGL
I
AVSELA
S
RV
MKK
A
A
R
GS
---
-
---
LLALFNLSL--YGAFLSASQ
A
A
Q
L
NIDNV
W
A
RDY
L
D
L
AQNKG
V
F
K
AGATN
V
S
I
QL
K
N
G
QTF
-
N
F
PNV
P
IP
DFS
P
A
S
--
N
----
K
G
A
T
T
S
IGG
A
Y
SV
TA
T
HN
G
TT
HH
A
IS
TQ
NWG
Q
S
S
Y
KYI
D
-
R
MTN
--
G
DF
AVT
RLDK
F
VVET
T
G
VKNSVDFSL
N
SHD
ALERYG
VEI-NGE
K
KIIG
FR
V
G
A
G
TT
Y
TVQN-
--
-----
-
-
-
-
---
G
NTYSTGQV-YNP
L
L
L
S
-
A
S
MFQ
L
-NWDNKR
-----
-PYN
N
T
-
TP
F
Y
N
ETTG
GDSGS
GF
Y
L
YDN
VKK
E
WV
M
L
G
-
-
T
LF
--
G
IAS-S
G
ADVW
S
ILNQY
D
ENTV
N
G
LK
NKFTQKV
Q
---
----
-
-
-
-
-
L
N
N
-NTMSLN
S
D
S
F
T
LAGNNTAV-
-
E--K
----
NNNN
Y
KDL
S
F
S
G
G
-
G
S
I
N
F
D
N
D
VNI
G
S
G
G
L
I
F
D
A
GHH
Y
T
V
TGNN
--
-K
TFKGAG
L
D
IGDNTT
V
D
WN
VK
G
VVG
DNLHKIG
A
GTL
N
V
NVS
--
Q
GN
NLK
T
G
D
G
L
V
V
L
NS
A
--
--
-
-
-
N
A
F
D
NI
Y
M
ASG
H
G
V
V
K
I
N
HSAA
L
N
Q
NND
Y
R
GI
F
F
TE
NGG
T
LDLNGY
D
Q
S
F
N
KIAATD
I
GA
L
ITNS
-
AV
Q
K
A
V
LS
V
N
-
------------------------------------------------------------------
----
-
----
-------
N
QSN
Y
M
YHG
S
V
S
GN
T
EINH
---
QFDT--QKNNSR
LILDG
N
VD
I
-
T
N
DINIK
N
SQ
L
T
MQGHAT
S
HA
VFREG-GVTCMLPG---
V
I
C
E
K
D
Y
V
SGIQQQ
E
NSAN
K
NNNTDY
K
T
NNQ
V
SSF
E
Q
P
DWE
NR
L
F
K
F
KT
L
N
L
I
NS
D
F
I
V
G
RNA
I
V
V
G
D
I
S
A
-
NN
S
T
LS
L
SGK
D
TK
V
H
ID
MYD
GKNIT
G
DG
F
G
FRQDIKD
G
V
S
V
--
-SP
ES
S
S
Y
F
G
N
V
T
L
N
N
fig|574521.7.peg.2961
Escherichia coli O127:H6 str. E2348/69 (4-712/1308)
MNKIY
A
LKY
C
HA
TGGL
I
AVSELA
S
RV
MKK
A
A
R
GS
---
-
---
LLALFNLSL--YGAFLSASQ
A
A
Q
L
NIDNV
W
A
RDY
L
D
L
AQNKG
V
F
K
AGATN
V
S
I
QL
K
N
G
QTF
-
N
F
PNV
P
IP
DFS
P
A
S
--
N
----
K
G
A
T
T
S
IGG
A
Y
SV
TA
T
HN
G
TT
HH
A
IS
TQ
NWG
Q
S
S
Y
KYI
D
-
R
MTN
--
G
DF
AVT
RLDK
F
VVET
T
G
VKNSVDFSL
N
SHD
ALERYG
VEI-NGE
K
KIIG
FR
V
G
A
G
TT
Y
TVQN-
--
-----
-
-
-
-
---
G
NTYSTGQV-YNP
L
L
L
S
-
A
S
MFQ
L
-NWDNKR
-----
-PYN
N
T
-
TP
F
Y
N
ETTG
GDSGS
GF
Y
L
YDN
VKK
E
WV
M
L
G
-
-
T
LF
--
G
IAS-S
G
ADVW
S
ILNQY
D
ENTV
N
G
LK
NKFTQKV
Q
---
----
-
-
-
-
-
L
N
N
-NTMSLN
S
D
S
F
T
LAGNNTAV-
-
E--K
----
NNNN
Y
KDL
S
F
S
G
G
-
G
S
I
N
F
D
N
D
VNI
G
S
G
G
L
I
F
D
A
GHH
Y
T
V
TGNN
--
-K
TFKGAG
L
D
IGDNTT
V
D
WN
VK
G
VVG
DNLHKIG
A
GTL
N
V
NVS
--
Q
GN
NLK
T
G
D
G
L
V
V
L
NS
A
--
--
-
-
-
N
A
F
D
NI
Y
M
ASG
H
G
V
V
K
I
N
HSAA
L
N
Q
NND
Y
R
GI
F
F
TE
NGG
T
LDLNGY
D
Q
S
F
N
KIAATD
I
GA
L
ITNS
-
AV
Q
K
A
V
LS
V
N
-
------------------------------------------------------------------
----
-
----
-------
N
QSN
Y
M
YHG
S
V
S
GN
T
EINH
---
QFDT--QKNNSR
LILDG
N
VD
I
-
T
N
DINIK
N
SQ
L
T
MQGHAT
S
HA
VFREG-GVTCMLPG---
V
I
C
E
K
D
Y
V
SGIQQQ
E
NSAN
K
NNNTDY
K
T
NNQ
V
SSF
E
Q
P
DWE
NR
L
F
K
F
KT
L
N
L
I
NS
D
F
I
V
G
RNA
I
V
V
G
D
I
S
A
-
NN
S
T
LS
L
SGK
D
TK
V
H
ID
MYD
GKNIT
G
DG
F
G
FRQDIKD
G
V
S
V
--
-SP
ES
S
S
Y
F
G
N
V
T
L
N
N
fig|340185.3.peg.3793
Escherichia coli E22 (1-704/1309)
MN
R
IYSLKY
C
HL
T
Q
GL
I
AVSELA
S
RV
SSK
T
G
R
-K
---
-
---
LLATFIVSALSYGA-AGHAY
A
A
Q
M
DTRNF
W
I
RDY
L
D
L
AQNKG
V
FQ
P
GA
YG
V
K
T
PL
K
N
G
GEF
-
S
F
PEV
T
IP
DFS
P
V
S
--
A
----
K
G
A
T
T
A
IG
N
A
Y
SV
TA
S
HN
G
TI
HH
A
VK
TQ
TWG
Q
S
D
Y
HYV
D
-
R
VTK
--
G
DF
AVQ
RLDK
F
VVET
A
G
ATEHADFNL
S
AAE
ALERYG
IEF-NGK
K
QIIG
FR
V
GSG
AT
G
V----
--
-----
-
-
-
-
---
-
TSYGVGQT-YNP
L
L
R
S
-
A
S
MFQ
L
-NWNNML
-----
-ATN
N
T
-
GG
F
Y
N
EVTG
GDSGS
GF
Y
L
YDN
QRK
KWV
I
L
G
-
-
T
TY
--
G
KAF-S
S
KDTW
A
FFARY
D
QNTV
D
T
LK
NTFTQEV
N
---
----
-
-
-
-
-
L
N
G
-QKMTVN
N
K
N
I
T
VNGNTTAI-
-
ELTR
----
NNKN
-
KDL
K
F
H
G
G
-
G
S
I
E
L
TD
N
LNS
G
T
G
G
L
I
F
D
E
GQH
Y
S
V
IGKD
--
-K
T
Y
KGAG
V
E
IGKGTV
V
D
W
S
VK
G
AAN
DNLHK
T
G
A
GTL
N
V
NVA
--
Q
GN
NLK
T
G
D
G
T
V
F
L
NA
E
--
--
-
-
-
K
A
FN
A
I
Y
V
ASG
R
GTV
K
L
G
QADA
L
D
K
NSD
Y
R
GI
Y
F
TS
R
GG
T
LDLNG
FS
Q
S
F
K
KIAATD
V
G
T
I
ITN
T
-
SD
K
T
A
T
LSL
Q
-
------------------------------------------------------------------
----
-
----
-------
N
PSR
Y
V
YHG
S
I
T
GN
T
NIEH
---
TGTQ--KSADSS
LI
I
DG
N
I
N
T
-
H
N
DITVR
N
SQ
L
R
L
QGHAT
T
HA
IFRDG-PRHCYVPG---
V
LC
D
K
D
F
V
ADFARL
E
SEAN
K
KNNSAY
K
T
NNQ
V
A
SF
D
Q
P
DWET
R
H
F
R
F
KT
L
N
L
E
N
A
E
F
T
T
A
RN
S
V
V
E
G
D
I
V
A
-
SN
S
T
L
K
L
G
G
-
D
VP
VF
ID
MYD
G
I
NIT
G
N
G
F
G
FRQDVRE
G
R
S
A
--
-DD
G
S
S
S
Y
TG
N
IT
L
Q
fig|562.373.peg.839
Escherichia coli 1125A (1-713/1300)
MNKIYSLKYS
HI
TGGL
I
AVSEL
S
G
RV
SSR
A
T
G
KK
---
K
HKR
ILALCFLGLLQ----SSYSF
AS
Q
M
DISNF
Y
I
RDY
M
DFAQNKG
I
FQAGATNI
E
I
VK
K
D
G
STL
-
K
L
PEV
P
FP
DFS
P
V
A
--
N
----
K
G
S
T
T
S
IGG
A
Y
SI
TA
T
HN
T
KN
HH
S
VA
TQ
NWG
N
S
TY
KQT
D
W
N
TSH
--
P
DF
AVS
RLDK
F
VVET
R
G
ATEGADISL
S
KQQ
ALERYG
VNY-KGE
K
KLIA
FRAGSG
VV
S
VKKN-
--
-----
-
-
-
-
---
G
RITPFNEVSYKP
E
M
L
N
-
G
S
FVH
I
DDWSGWL
-----
ILTN
N
Q
F
DE
F
N
N
IASQ
GDSGS
AL
F
V
YDN
QKK
KWV
V
A
G
-
-
T
VW
--
G
IYNYA
N
GKNH
A
AYSKW
N
QTTI
D
N
LK
NKYSYNV
D
---
----
-
-
-
-
-
M
S
G
AQVATIE
NG
K
LT
GTGSDTT--
-
-DIK
----
N---
-
KDL
I
F
T
G
G
-
G
D
I
L
LKSS
FDN
GAG
G
L
V
F
N
D
KKT
Y
R
V
NGDD
--
-F
TFKGAG
V
D
TRNGST
VEWN
IR
Y
DNK
DNLHKIG
D
GTL
D
V
RKT
--
Q
NT
NLK
T
GEG
L
VIL
GA
E
--
--
-
-
-
K
TFNNI
Y
I
T
SG
D
GTV
R
LN
AENA
L
S
-
GGE
Y
N
GI
F
F
AK
NGG
T
LDLNGYNQ
S
F
N
KIAATD
S
GA
V
ITN
T
-
ST
K
K
S
I
LSLN
-
------------------------------------------------------------------
----
-
----
-------
N
TAD
YIYHG
N
I
N
GNL
DVLQ
---
HHET--KKENRR
LILDG
G
VD
T
-
T
N
DISLR
N
TQ
L
S
MQGHAT
E
HA
IYRDG-AFSCSLPAPMR
FLCG
S
D
Y
V
AGMQNT
E
ADAV
K
QNGNAY
K
T
NN
A
V
S
DL
S
Q
P
DWETG
T
F
R
F
GT
L
H
L
E
NS
D
F
S
V
G
RNA
N
V
I
G
D
I
Q
A
-
SK
SNITIG
--
D
TT
AYID
LHA
GKNIT
G
DG
F
G
FRQNIVR
G
N
S
Q
--
---
GET
L
FTG
G
ITA
E
D
S
fig|562.371.peg.2017
Escherichia coli 1044A (1-713/1300)
MNKIYSLKYS
HI
TGGL
I
AVSEL
S
G
RV
SSR
A
T
G
KK
---
K
HKR
ILALCFLGLLQ----SSYSF
AS
Q
M
DISNF
Y
I
RDY
M
DFAQNKG
I
FQAGATNI
E
I
VK
K
D
G
STL
-
K
L
PEV
P
FP
DFS
P
V
A
--
N
----
K
G
S
T
T
S
IGG
A
Y
SI
TA
T
HN
T
KN
HH
S
VA
TQ
NWG
N
S
TY
KQT
D
W
N
TSH
--
P
DF
AVS
RLDK
F
VVET
R
G
ATEGADISL
S
KQQ
ALERYG
VNY-KGE
K
KLIA
FRAGSG
VV
S
VKKN-
--
-----
-
-
-
-
---
G
RITPFNEVSYKP
E
M
L
N
-
G
S
FVH
I
DDWSGWL
-----
ILTN
N
Q
F
DE
F
N
N
IASQ
GDSGS
AL
F
V
YDN
QKK
KWV
V
A
G
-
-
T
VW
--
G
IYNYA
N
GKNH
A
AYSKW
N
QTTI
D
N
LK
NKYSYNV
D
---
----
-
-
-
-
-
M
S
G
AQVATIE
NG
K
LT
GTGSDTT--
-
-DIK
----
N---
-
KDL
I
F
T
G
G
-
G
D
I
L
LKSS
FDN
GAG
G
L
V
F
N
D
KKT
Y
R
V
NGDD
--
-F
TFKGAG
V
D
TRNGST
VEWN
IR
Y
DNK
DNLHKIG
D
GTL
D
V
RKT
--
Q
NT
NLK
T
GEG
L
VIL
GA
E
--
--
-
-
-
K
TFNNI
Y
I
T
SG
D
GTV
R
LN
AENA
L
S
-
GGE
Y
N
GI
F
F
AK
NGG
T
LDLNGYNQ
S
F
N
KIAATD
S
GA
V
ITN
T
-
ST
K
K
S
I
LSLN
-
------------------------------------------------------------------
----
-
----
-------
N
TAD
YIYHG
N
I
N
GNL
DVLQ
---
HHET--KKENRR
LILDG
G
VD
T
-
T
N
DISLR
N
TQ
L
S
MQGHAT
E
HA
IYRDG-AFSCSLPAPMR
FLCG
S
D
Y
V
AGMQNT
E
ADAV
K
QNGNAY
K
T
NN
A
V
S
DL
S
Q
P
DWETG
T
F
R
F
GT
L
H
L
E
NS
D
F
S
V
G
RNA
N
V
I
G
D
I
Q
A
-
SK
SNITIG
--
D
TT
AYID
LHA
GKNIT
G
DG
F
G
FRQNIVR
G
N
S
Q
--
---
GET
L
FTG
G
ITA
E
D
S
fig|562.372.peg.393
Escherichia coli 1212A (1-713/1300)
MNKIYSLKYS
HI
TGGL
I
AVSEL
S
G
RV
SSR
A
T
G
KK
---
K
HKR
ILALCFLGLLQ----SSYSF
AS
Q
M
DISNF
Y
I
RDY
M
DFAQNKG
I
FQAGATNI
E
I
VK
K
D
G
STL
-
K
L
PEV
P
FP
DFS
P
V
A
--
N
----
K
G
S
T
T
S
IGG
A
Y
SI
TA
T
HN
T
KN
HH
S
VA
TQ
NWG
N
S
TY
KQT
D
W
N
TSH
--
P
DF
AVS
RLDK
F
VVET
R
G
ATEGADISL
S
KQQ
ALERYG
VNY-KGE
K
KLIA
FRAGSG
VV
S
VKKN-
--
-----
-
-
-
-
---
G
RITPFNEVSYKP
E
M
L
N
-
G
S
FVH
I
DDWSGWL
-----
ILTN
N
Q
F
DE
F
N
N
IASQ
GDSGS
AL
F
V
YDN
QKK
KWV
V
A
G
-
-
T
VW
--
G
IYNYA
N
GKNH
A
AYSKW
N
QTTI
D
N
LK
NKYSYNV
D
---
----
-
-
-
-
-
M
S
G
AQVATIE
NG
K
LT
GTGSDTT--
-
-DIK
----
N---
-
KDL
I
F
T
G
G
-
G
D
I
L
LKSS
FDN
GAG
G
L
V
F
N
D
KKT
Y
R
V
NGDD
--
-F
TFKGAG
V
D
TRNGST
VEWN
IR
Y
DNK
DNLHKIG
D
GTL
D
V
RKT
--
Q
NT
NLK
T
GEG
L
VIL
GA
E
--
--
-
-
-
K
TFNNI
Y
I
T
SG
D
GTV
R
LN
AENA
L
S
-
GGE
Y
N
GI
F
F
AK
NGG
T
LDLNGYNQ
S
F
N
KIAATD
S
GA
V
ITN
T
-
ST
K
K
S
I
LSLN
-
------------------------------------------------------------------
----
-
----
-------
N
TAD
YIYHG
N
I
N
GNL
DVLQ
---
HHET--KKENRR
LILDG
G
VD
T
-
T
N
DISLR
N
TQ
L
S
MQGHAT
E
HA
IYRDG-AFSCSLPAPMR
FLCG
S
D
Y
V
AGMQNT
E
ADAV
K
QNGNAY
K
T
NN
A
V
S
DL
S
Q
P
DWETG
T
F
R
F
GT
L
H
L
E
NS
D
F
S
V
G
RNA
N
V
I
G
D
I
Q
A
-
SK
SNITIG
--
D
TT
AYID
LHA
GKNIT
G
DG
F
G
FRQNIVR
G
N
S
Q
--
---
GET
L
FTG
G
ITA
E
D
S
fig|562.374.peg.1886
Escherichia coli 536A (1-713/1300)
MNKIYSLKYS
HI
TGGL
I
AVSEL
S
G
RV
SSR
A
T
G
KK
---
K
HKR
ILALCFLGLLQ----SSYSF
AS
Q
M
DISNF
Y
I
RDY
M
DFAQNKG
I
FQAGATNI
E
I
VK
K
D
G
STL
-
K
L
PEV
P
FP
DFS
P
V
A
--
N
----
K
G
S
T
T
S
IGG
A
Y
SI
TA
T
HN
T
KN
HH
S
VA
TQ
NWG
N
S
TY
KQT
D
W
N
TSH
--
P
DF
AVS
RLDK
F
VVET
R
G
ATEGADISL
S
KQQ
ALERYG
VNY-KGE
K
KLIA
FRAGSG
VV
S
VKKN-
--
-----
-
-
-
-
---
G
RITPFNEVSYKP
E
M
L
N
-
G
S
FVH
I
DDWSGWL
-----
ILTN
N
Q
F
DE
F
N
N
IASQ
GDSGS
AL
F
V
YDN
QKK
KWV
V
A
G
-
-
T
VW
--
G
IYNYA
N
GKNH
A
AYSKW
N
QTTI
D
N
LK
NKYSYNV
D
---
----
-
-
-
-
-
M
S
G
AQVATIE
NG
K
LT
GTGSDTT--
-
-DIK
----
N---
-
KDL
I
F
T
G
G
-
G
D
I
L
LKSS
FDN
GAG
G
L
V
F
N
D
KKT
Y
R
V
NGDD
--
-F
TFKGAG
V
D
TRNGST
VEWN
IR
Y
DNK
DNLHKIG
D
GTL
D
V
RKT
--
Q
NT
NLK
T
GEG
L
VIL
GA
E
--
--
-
-
-
K
TFNNI
Y
I
T
SG
D
GTV
R
LN
AENA
L
S
-
GGE
Y
N
GI
F
F
AK
NGG
T
LDLNGYNQ
S
F
N
KIAATD
S
GA
V
ITN
T
-
ST
K
K
S
I
LSLN
-
------------------------------------------------------------------
----
-
----
-------
N
TAD
YIYHG
N
I
N
GNL
DVLQ
---
HHET--KKENRR
LILDG
G
VD
T
-
T
N
DISLR
N
TQ
L
S
MQGHAT
E
HA
IYRDG-AFSCSLPAPMR
FLCG
S
D
Y
V
AGMQNT
E
ADAV
K
QNGNAY
K
T
NN
A
V
S
DL
S
Q
P
DWETG
T
F
R
F
GT
L
H
L
E
NS
D
F
S
V
G
RNA
N
V
I
G
D
I
Q
A
-
SK
SNITIG
--
D
TT
AYID
LHA
GKNIT
G
DG
F
G
FRQNIVR
G
N
S
Q
--
---
GET
L
FTG
G
ITA
E
D
S
fig|83334.1.peg.82
Escherichia coli O157:H7 (1-713/1300)
MNKIYSLKYS
HI
TGGL
I
AVSEL
S
G
RV
SSR
A
T
G
KK
---
K
HKR
ILALCFLGLLQ----SSYSF
AS
Q
M
DISNF
Y
I
RDY
M
DFAQNKG
I
FQAGATNI
E
I
VK
K
D
G
STL
-
K
L
PEV
P
FP
DFS
P
V
A
--
N
----
K
G
S
T
T
S
IGG
A
Y
SI
TA
T
HN
T
KN
HH
S
VA
TQ
NWG
N
S
TY
KQT
D
W
N
TSH
--
P
DF
AVS
RLDK
F
VVET
R
G
ATEGADISL
S
KQQ
ALERYG
VNY-KGE
K
KLIA
FRAGSG
VV
S
VKKN-
--
-----
-
-
-
-
---
G
RITPFNEVSYKP
E
M
L
N
-
G
S
FVH
I
DDWSGWL
-----
ILTN
N
Q
F
DE
F
N
N
IASQ
GDSGS
AL
F
V
YDN
QKK
KWV
V
A
G
-
-
T
VW
--
G
IYNYA
N
GKNH
A
AYSKW
N
QTTI
D
N
LK
NKYSYNV
D
---
----
-
-
-
-
-
M
S
G
AQVATIE
NG
K
LT
GTGSDTT--
-
-DIK
----
N---
-
KDL
I
F
T
G
G
-
G
D
I
L
LKSS
FDN
GAG
G
L
V
F
N
D
KKT
Y
R
V
NGDD
--
-F
TFKGAG
V
D
TRNGST
VEWN
IR
Y
DNK
DNLHKIG
D
GTL
D
V
RKT
--
Q
NT
NLK
T
GEG
L
VIL
GA
E
--
--
-
-
-
K
TFNNI
Y
I
T
SG
D
GTV
R
LN
AENA
L
S
-
GGE
Y
N
GI
F
F
AK
NGG
T
LDLNGYNQ
S
F
N
KIAATD
S
GA
V
ITN
T
-
ST
K
K
S
I
LSLN
-
------------------------------------------------------------------
----
-
----
-------
N
TAD
YIYHG
N
I
N
GNL
DVLQ
---
HHET--KKENRR
LILDG
G
VD
T
-
T
N
DISLR
N
TQ
L
S
MQGHAT
E
HA
IYRDG-AFSCSLPAPMR
FLCG
S
D
Y
V
AGMQNT
E
ADAV
K
QNGNAY
K
T
NN
A
V
S
DL
S
Q
P
DWETG
T
F
R
F
GT
L
H
L
E
NS
D
F
S
V
G
RNA
N
V
I
G
D
I
Q
A
-
SK
SNITIG
--
D
TT
AYID
LHA
GKNIT
G
DG
F
G
FRQNIVR
G
N
S
Q
--
---
GET
L
FTG
G
ITA
E
D
S
fig|155864.8.peg.5610
Escherichia coli O157:H7 EDL933 (1-713/1300)
MNKIYSLKYS
HI
TGGL
I
AVSEL
S
G
RV
SSR
A
T
G
KK
---
K
HKR
ILALCFLGLLQ----SSYSF
AS
Q
M
DISNF
Y
I
RDY
M
DFAQNKG
I
FQAGATNI
E
I
VK
K
D
G
STL
-
K
L
PEV
P
FP
DFS
P
V
A
--
N
----
K
G
S
T
T
S
IGG
A
Y
SI
TA
T
HN
T
KN
HH
S
VA
TQ
NWG
N
S
TY
KQT
D
W
N
TSH
--
P
DF
AVS
RLDK
F
VVET
R
G
ATEGADISL
S
KQQ
ALERYG
VNY-KGE
K
KLIA
FRAGSG
VV
S
VKKN-
--
-----
-
-
-
-
---
G
RITPFNEVSYKP
E
M
L
N
-
G
S
FVH
I
DDWSGWL
-----
ILTN
N
Q
F
DE
F
N
N
IASQ
GDSGS
AL
F
V
YDN
QKK
KWV
V
A
G
-
-
T
VW
--
G
IYNYA
N
GKNH
A
AYSKW
N
QTTI
D
N
LK
NKYSYNV
D
---
----
-
-
-
-
-
M
S
G
AQVATIE
NG
K
LT
GTGSDTT--
-
-DIK
----
N---
-
KDL
I
F
T
G
G
-
G
D
I
L
LKSS
FDN
GAG
G
L
V
F
N
D
KKT
Y
R
V
NGDD
--
-F
TFKGAG
V
D
TRNGST
VEWN
IR
Y
DNK
DNLHKIG
D
GTL
D
V
RKT
--
Q
NT
NLK
T
GEG
L
VIL
GA
E
--
--
-
-
-
K
TFNNI
Y
I
T
SG
D
GTV
R
LN
AENA
L
S
-
GGE
Y
N
GI
F
F
AK
NGG
T
LDLNGYNQ
S
F
N
KIAATD
S
GA
V
ITN
T
-
ST
K
K
S
I
LSLN
-
------------------------------------------------------------------
----
-
----
-------
N
TAD
YIYHG
N
I
N
GNL
DVLQ
---
HHET--KKENRR
LILDG
G
VD
T
-
T
N
DISLR
N
TQ
L
S
MQGHAT
E
HA
IYRDG-AFSCSLPAPMR
FLCG
S
D
Y
V
AGMQNT
E
ADAV
K
QNGNAY
K
T
NN
A
V
S
DL
S
Q
P
DWETG
T
F
R
F
GT
L
H
L
E
NS
D
F
S
V
G
RNA
N
V
I
G
D
I
Q
A
-
SK
SNITIG
--
D
TT
AYID
LHA
GKNIT
G
DG
F
G
FRQNIVR
G
N
S
Q
--
---
GET
L
FTG
G
ITA
E
D
S
fig|444454.5.peg.647
Escherichia coli O157:H7 str. EC4024 (1-713/1300)
MNKIYSLKYS
HI
TGGL
I
AVSEL
S
G
RV
SSR
A
T
G
KK
---
K
HKR
ILALCFLGLLQ----SSYSF
AS
Q
M
DISNF
Y
I
RDY
M
DFAQNKG
I
FQAGATNI
E
I
VK
K
D
G
STL
-
K
L
PEV
P
FP
DFS
P
V
A
--
N
----
K
G
S
T
T
S
IGG
A
Y
SI
TA
T
HN
T
KN
HH
S
VA
TQ
NWG
N
S
TY
KQT
D
W
N
TSH
--
P
DF
AVS
RLDK
F
VVET
R
G
ATEGADISL
S
KQQ
ALERYG
VNY-KGE
K
KLIA
FRAGSG
VV
S
VKKN-
--
-----
-
-
-
-
---
G
RITPFNEVSYKP
E
M
L
N
-
G
S
FVH
I
DDWSGWL
-----
ILTN
N
Q
F
DE
F
N
N
IASQ
GDSGS
AL
F
V
YDN
QKK
KWV
V
A
G
-
-
T
VW
--
G
IYNYA
N
GKNH
A
AYSKW
N
QTTI
D
N
LK
NKYSYNV
D
---
----
-
-
-
-
-
M
S
G
AQVATIE
NG
K
LT
GTGSDTT--
-
-DIK
----
N---
-
KDL
I
F
T
G
G
-
G
D
I
L
LKSS
FDN
GAG
G
L
V
F
N
D
KKT
Y
R
V
NGDD
--
-F
TFKGAG
V
D
TRNGST
VEWN
IR
Y
DNK
DNLHKIG
D
GTL
D
V
RKT
--
Q
NT
NLK
T
GEG
L
VIL
GA
E
--
--
-
-
-
K
TFNNI
Y
I
T
SG
D
GTV
R
LN
AENA
L
S
-
GGE
Y
N
GI
F
F
AK
NGG
T
LDLNGYNQ
S
F
N
KIAATD
S
GA
V
ITN
T
-
ST
K
K
S
I
LSLN
-
------------------------------------------------------------------
----
-
----
-------
N
TAD
YIYHG
N
I
N
GNL
DVLQ
---
HHET--KKENRR
LILDG
G
VD
T
-
T
N
DISLR
N
TQ
L
S
MQGHAT
E
HA
IYRDG-AFSCSLPAPMR
FLCG
S
D
Y
V
AGMQNT
E
ADAV
K
QNGNAY
K
T
NN
A
V
S
DL
S
Q
P
DWETG
T
F
R
F
GT
L
H
L
E
NS
D
F
S
V
G
RNA
N
V
I
G
D
I
Q
A
-
SK
SNITIG
--
D
TT
AYID
LHA
GKNIT
G
DG
F
G
FRQNIVR
G
N
S
Q
--
---
GET
L
FTG
G
ITA
E
D
S
fig|444449.5.peg.5680
Escherichia coli O157:H7 str. EC4042 (1-713/1300)
MNKIYSLKYS
HI
TGGL
I
AVSEL
S
G
RV
SSR
A
T
G
KK
---
K
HKR
ILALCFLGLLQ----SSYSF
AS
Q
M
DISNF
Y
I
RDY
M
DFAQNKG
I
FQAGATNI
E
I
VK
K
D
G
STL
-
K
L
PEV
P
FP
DFS
P
V
A
--
N
----
K
G
S
T
T
S
IGG
A
Y
SI
TA
T
HN
T
KN
HH
S
VA
TQ
NWG
N
S
TY
KQT
D
W
N
TSH
--
P
DF
AVS
RLDK
F
VVET
R
G
ATEGADISL
S
KQQ
ALERYG
VNY-KGE
K
KLIA
FRAGSG
VV
S
VKKN-
--
-----
-
-
-
-
---
G
RITPFNEVSYKP
E
M
L
N
-
G
S
FVH
I
DDWSGWL
-----
ILTN
N
Q
F
DE
F
N
N
IASQ
GDSGS
AL
F
V
YDN
QKK
KWV
V
A
G
-
-
T
VW
--
G
IYNYA
N
GKNH
A
AYSKW
N
QTTI
D
N
LK
NKYSYNV
D
---
----
-
-
-
-
-
M
S
G
AQVATIE
NG
K
LT
GTGSDTT--
-
-DIK
----
N---
-
KDL
I
F
T
G
G
-
G
D
I
L
LKSS
FDN
GAG
G
L
V
F
N
D
KKT
Y
R
V
NGDD
--
-F
TFKGAG
V
D
TRNGST
VEWN
IR
Y
DNK
DNLHKIG
D
GTL
D
V
RKT
--
Q
NT
NLK
T
GEG
L
VIL
GA
E
--
--
-
-
-
K
TFNNI
Y
I
T
SG
D
GTV
R
LN
AENA
L
S
-
GGE
Y
N
GI
F
F
AK
NGG
T
LDLNGYNQ
S
F
N
KIAATD
S
GA
V
ITN
T
-
ST
K
K
S
I
LSLN
-
------------------------------------------------------------------
----
-
----
-------
N
TAD
YIYHG
N
I
N
GNL
DVLQ
---
HHET--KKENRR
LILDG
G
VD
T
-
T
N
DISLR
N
TQ
L
S
MQGHAT
E
HA
IYRDG-AFSCSLPAPMR
FLCG
S
D
Y
V
AGMQNT
E
ADAV
K
QNGNAY
K
T
NN
A
V
S
DL
S
Q
P
DWETG
T
F
R
F
GT
L
H
L
E
NS
D
F
S
V
G
RNA
N
V
I
G
D
I
Q
A
-
SK
SNITIG
--
D
TT
AYID
LHA
GKNIT
G
DG
F
G
FRQNIVR
G
N
S
Q
--
---
GET
L
FTG
G
ITA
E
D
S
fig|444448.5.peg.5650
Escherichia coli O157:H7 str. EC4045 (1-713/1300)
MNKIYSLKYS
HI
TGGL
I
AVSEL
S
G
RV
SSR
A
T
G
KK
---
K
HKR
ILALCFLGLLQ----SSYSF
AS
Q
M
DISNF
Y
I
RDY
M
DFAQNKG
I
FQAGATNI
E
I
VK
K
D
G
STL
-
K
L
PEV
P
FP
DFS
P
V
A
--
N
----
K
G
S
T
T
S
IGG
A
Y
SI
TA
T
HN
T
KN
HH
S
VA
TQ
NWG
N
S
TY
KQT
D
W
N
TSH
--
P
DF
AVS
RLDK
F
VVET
R
G
ATEGADISL
S
KQQ
ALERYG
VNY-KGE
K
KLIA
FRAGSG
VV
S
VKKN-
--
-----
-
-
-
-
---
G
RITPFNEVSYKP
E
M
L
N
-
G
S
FVH
I
DDWSGWL
-----
ILTN
N
Q
F
DE
F
N
N
IASQ
GDSGS
AL
F
V
YDN
QKK
KWV
V
A
G
-
-
T
VW
--
G
IYNYA
N
GKNH
A
AYSKW
N
QTTI
D
N
LK
NKYSYNV
D
---
----
-
-
-
-
-
M
S
G
AQVATIE
NG
K
LT
GTGSDTT--
-
-DIK
----
N---
-
KDL
I
F
T
G
G
-
G
D
I
L
LKSS
FDN
GAG
G
L
V
F
N
D
KKT
Y
R
V
NGDD
--
-F
TFKGAG
V
D
TRNGST
VEWN
IR
Y
DNK
DNLHKIG
D
GTL
D
V
RKT
--
Q
NT
NLK
T
GEG
L
VIL
GA
E
--
--
-
-
-
K
TFNNI
Y
I
T
SG
D
GTV
R
LN
AENA
L
S
-
GGE
Y
N
GI
F
F
AK
NGG
T
LDLNGYNQ
S
F
N
KIAATD
S
GA
V
ITN
T
-
ST
K
K
S
I
LSLN
-
------------------------------------------------------------------
----
-
----
-------
N
TAD
YIYHG
N
I
N
GNL
DVLQ
---
HHET--KKENRR
LILDG
G
VD
T
-
T
N
DISLR
N
TQ
L
S
MQGHAT
E
HA
IYRDG-AFSCSLPAPMR
FLCG
S
D
Y
V
AGMQNT
E
ADAV
K
QNGNAY
K
T
NN
A
V
S
DL
S
Q
P
DWETG
T
F
R
F
GT
L
H
L
E
NS
D
F
S
V
G
RNA
N
V
I
G
D
I
Q
A
-
SK
SNITIG
--
D
TT
AYID
LHA
GKNIT
G
DG
F
G
FRQNIVR
G
N
S
Q
--
---
GET
L
FTG
G
ITA
E
D
S
fig|444453.5.peg.4375
Escherichia coli O157:H7 str. EC4076 (1-713/1300)
MNKIYSLKYS
HI
TGGL
I
AVSEL
S
G
RV
SSR
A
T
G
KK
---
K
HKR
ILALCFLGLLQ----SSYSF
AS
Q
M
DISNF
Y
I
RDY
M
DFAQNKG
I
FQAGATNI
E
I
VK
K
D
G
STL
-
K
L
PEV
P
FP
DFS
P
V
A
--
N
----
K
G
S
T
T
S
IGG
A
Y
SI
TA
T
HN
T
KN
HH
S
VA
TQ
NWG
N
S
TY
KQT
D
W
N
TSH
--
P
DF
AVS
RLDK
F
VVET
R
G
ATEGADISL
S
KQQ
ALERYG
VNY-KGE
K
KLIA
FRAGSG
VV
S
VKKN-
--
-----
-
-
-
-
---
G
RITPFNEVSYKP
E
M
L
N
-
G
S
FVH
I
DDWSGWL
-----
ILTN
N
Q
F
DE
F
N
N
IASQ
GDSGS
AL
F
V
YDN
QKK
KWV
V
A
G
-
-
T
VW
--
G
IYNYA
N
GKNH
A
AYSKW
N
QTTI
D
N
LK
NKYSYNV
D
---
----
-
-
-
-
-
M
S
G
AQVATIE
NG
K
LT
GTGSDTT--
-
-DIK
----
N---
-
KDL
I
F
T
G
G
-
G
D
I
L
LKSS
FDN
GAG
G
L
V
F
N
D
KKT
Y
R
V
NGDD
--
-F
TFKGAG
V
D
TRNGST
VEWN
IR
Y
DNK
DNLHKIG
D
GTL
D
V
RKT
--
Q
NT
NLK
T
GEG
L
VIL
GA
E
--
--
-
-
-
K
TFNNI
Y
I
T
SG
D
GTV
R
LN
AENA
L
S
-
GGE
Y
N
GI
F
F
AK
NGG
T
LDLNGYNQ
S
F
N
KIAATD
S
GA
V
ITN
T
-
ST
K
K
S
I
LSLN
-
------------------------------------------------------------------
----
-
----
-------
N
TAD
YIYHG
N
I
N
GNL
DVLQ
---
HHET--KKENRR
LILDG
G
VD
T
-
T
N
DISLR
N
TQ
L
S
MQGHAT
E
HA
IYRDG-AFSCSLPAPMR
FLCG
S
D
Y
V
AGMQNT
E
ADAV
K
QNGNAY
K
T
NN
A
V
S
DL
S
Q
P
DWETG
T
F
R
F
GT
L
H
L
E
NS
D
F
S
V
G
RNA
N
V
I
G
D
I
Q
A
-
SK
SNITIG
--
D
TT
AYID
LHA
GKNIT
G
DG
F
G
FRQNIVR
G
N
S
Q
--
---
GET
L
FTG
G
ITA
E
D
S
fig|444452.5.peg.3624
Escherichia coli O157:H7 str. EC4113 (1-713/1300)
MNKIYSLKYS
HI
TGGL
I
AVSEL
S
G
RV
SSR
A
T
G
KK
---
K
HKR
ILALCFLGLLQ----SSYSF
AS
Q
M
DISNF
Y
I
RDY
M
DFAQNKG
I
FQAGATNI
E
I
VK
K
D
G
STL
-
K
L
PEV
P
FP
DFS
P
V
A
--
N
----
K
G
S
T
T
S
IGG
A
Y
SI
TA
T
HN
T
KN
HH
S
VA
TQ
NWG
N
S
TY
KQT
D
W
N
TSH
--
P
DF
AVS
RLDK
F
VVET
R
G
ATEGADISL
S
KQQ
ALERYG
VNY-KGE
K
KLIA
FRAGSG
VV
S
VKKN-
--
-----
-
-
-
-
---
G
RITPFNEVSYKP
E
M
L
N
-
G
S
FVH
I
DDWSGWL
-----
ILTN
N
Q
F
DE
F
N
N
IASQ
GDSGS
AL
F
V
YDN
QKK
KWV
V
A
G
-
-
T
VW
--
G
IYNYA
N
GKNH
A
AYSKW
N
QTTI
D
N
LK
NKYSYNV
D
---
----
-
-
-
-
-
M
S
G
AQVATIE
NG
K
LT
GTGSDTT--
-
-DIK
----
N---
-
KDL
I
F
T
G
G
-
G
D
I
L
LKSS
FDN
GAG
G
L
V
F
N
D
KKT
Y
R
V
NGDD
--
-F
TFKGAG
V
D
TRNGST
VEWN
IR
Y
DNK
DNLHKIG
D
GTL
D
V
RKT
--
Q
NT
NLK
T
GEG
L
VIL
GA
E
--
--
-
-
-
K
TFNNI
Y
I
T
SG
D
GTV
R
LN
AENA
L
S
-
GGE
Y
N
GI
F
F
AK
NGG
T
LDLNGYNQ
S
F
N
KIAATD
S
GA
V
ITN
T
-
ST
K
K
S
I
LSLN
-
------------------------------------------------------------------
----
-
----
-------
N
TAD
YIYHG
N
I
N
GNL
DVLQ
---
HHET--KKENRR
LILDG
G
VD
T
-
T
N
DISLR
N
TQ
L
S
MQGHAT
E
HA
IYRDG-AFSCSLPAPMR
FLCG
S
D
Y
V
AGMQNT
E
ADAV
K
QNGNAY
K
T
NN
A
V
S
DL
S
Q
P
DWETG
T
F
R
F
GT
L
H
L
E
NS
D
F
S
V
G
RNA
N
V
I
G
D
I
Q
A
-
SK
SNITIG
--
D
TT
AYID
LHA
GKNIT
G
DG
F
G
FRQNIVR
G
N
S
Q
--
---
GET
L
FTG
G
ITA
E
D
S
fig|444450.8.peg.77
Escherichia coli O157:H7 str. EC4115 (1-713/1300)
MNKIYSLKYS
HI
TGGL
I
AVSEL
S
G
RV
SSR
A
T
G
KK
---
K
HKR
ILALCFLGLLQ----SSYSF
AS
Q
M
DISNF
Y
I
RDY
M
DFAQNKG
I
FQAGATNI
E
I
VK
K
D
G
STL
-
K
L
PEV
P
FP
DFS
P
V
A
--
N
----
K
G
S
T
T
S
IGG
A
Y
SI
TA
T
HN
T
KN
HH
S
VA
TQ
NWG
N
S
TY
KQT
D
W
N
TSH
--
P
DF
AVS
RLDK
F
VVET
R
G
ATEGADISL
S
KQQ
ALERYG
VNY-KGE
K
KLIA
FRAGSG
VV
S
VKKN-
--
-----
-
-
-
-
---
G
RITPFNEVSYKP
E
M
L
N
-
G
S
FVH
I
DDWSGWL
-----
ILTN
N
Q
F
DE
F
N
N
IASQ
GDSGS
AL
F
V
YDN
QKK
KWV
V
A
G
-
-
T
VW
--
G
IYNYA
N
GKNH
A
AYSKW
N
QTTI
D
N
LK
NKYSYNV
D
---
----
-
-
-
-
-
M
S
G
AQVATIE
NG
K
LT
GTGSDTT--
-
-DIK
----
N---
-
KDL
I
F
T
G
G
-
G
D
I
L
LKSS
FDN
GAG
G
L
V
F
N
D
KKT
Y
R
V
NGDD
--
-F
TFKGAG
V
D
TRNGST
VEWN
IR
Y
DNK
DNLHKIG
D
GTL
D
V
RKT
--
Q
NT
NLK
T
GEG
L
VIL
GA
E
--
--
-
-
-
K
TFNNI
Y
I
T
SG
D
GTV
R
LN
AENA
L
S
-
GGE
Y
N
GI
F
F
AK
NGG
T
LDLNGYNQ
S
F
N
KIAATD
S
GA
V
ITN
T
-
ST
K
K
S
I
LSLN
-
------------------------------------------------------------------
----
-
----
-------
N
TAD
YIYHG
N
I
N
GNL
DVLQ
---
HHET--KKENRR
LILDG
G
VD
T
-
T
N
DISLR
N
TQ
L
S
MQGHAT
E
HA
IYRDG-AFSCSLPAPMR
FLCG
S
D
Y
V
AGMQNT
E
ADAV
K
QNGNAY
K
T
NN
A
V
S
DL
S
Q
P
DWETG
T
F
R
F
GT
L
H
L
E
NS
D
F
S
V
G
RNA
N
V
I
G
D
I
Q
A
-
SK
SNITIG
--
D
TT
AYID
LHA
GKNIT
G
DG
F
G
FRQNIVR
G
N
S
Q
--
---
GET
L
FTG
G
ITA
E
D
S
fig|444451.5.peg.4166
Escherichia coli O157:H7 str. EC4196 (1-713/1300)
MNKIYSLKYS
HI
TGGL
I
AVSEL
S
G
RV
SSR
A
T
G
KK
---
K
HKR
ILALCFLGLLQ----SSYSF
AS
Q
M
DISNF
Y
I
RDY
M
DFAQNKG
I
FQAGATNI
E
I
VK
K
D
G
STL
-
K
L
PEV
P
FP
DFS
P
V
A
--
N
----
K
G
S
T
T
S
IGG
A
Y
SI
TA
T
HN
T
KN
HH
S
VA
TQ
NWG
N
S
TY
KQT
D
W
N
TSH
--
P
DF
AVS
RLDK
F
VVET
R
G
ATEGADISL
S
KQQ
ALERYG
VNY-KGE
K
KLIA
FRAGSG
VV
S
VKKN-
--
-----
-
-
-
-
---
G
RITPFNEVSYKP
E
M
L
N
-
G
S
FVH
I
DDWSGWL
-----
ILTN
N
Q
F
DE
F
N
N
IASQ
GDSGS
AL
F
V
YDN
QKK
KWV
V
A
G
-
-
T
VW
--
G
IYNYA
N
GKNH
A
AYSKW
N
QTTI
D
N
LK
NKYSYNV
D
---
----
-
-
-
-
-
M
S
G
AQVATIE
NG
K
LT
GTGSDTT--
-
-DIK
----
N---
-
KDL
I
F
T
G
G
-
G
D
I
L
LKSS
FDN
GAG
G
L
V
F
N
D
KKT
Y
R
V
NGDD
--
-F
TFKGAG
V
D
TRNGST
VEWN
IR
Y
DNK
DNLHKIG
D
GTL
D
V
RKT
--
Q
NT
NLK
T
GEG
L
VIL
GA
E
--
--
-
-
-
K
TFNNI
Y
I
T
SG
D
GTV
R
LN
AENA
L
S
-
GGE
Y
N
GI
F
F
AK
NGG
T
LDLNGYNQ
S
F
N
KIAATD
S
GA
V
ITN
T
-
ST
K
K
S
I
LSLN
-
------------------------------------------------------------------
----
-
----
-------
N
TAD
YIYHG
N
I
N
GNL
DVLQ
---
HHET--KKENRR
LILDG
G
VD
T
-
T
N
DISLR
N
TQ
L
S
MQGHAT
E
HA
IYRDG-AFSCSLPAPMR
FLCG
S
D
Y
V
AGMQNT
E
ADAV
K
QNGNAY
K
T
NN
A
V
S
DL
S
Q
P
DWETG
T
F
R
F
GT
L
H
L
E
NS
D
F
S
V
G
RNA
N
V
I
G
D
I
Q
A
-
SK
SNITIG
--
D
TT
AYID
LHA
GKNIT
G
DG
F
G
FRQNIVR
G
N
S
Q
--
---
GET
L
FTG
G
ITA
E
D
S
fig|444447.5.peg.5731
Escherichia coli O157:H7 str. EC4206 (1-713/1300)
MNKIYSLKYS
HI
TGGL
I
AVSEL
S
G
RV
SSR
A
T
G
KK
---
K
HKR
ILALCFLGLLQ----SSYSF
AS
Q
M
DISNF
Y
I
RDY
M
DFAQNKG
I
FQAGATNI
E
I
VK
K
D
G
STL
-
K
L
PEV
P
FP
DFS
P
V
A
--
N
----
K
G
S
T
T
S
IGG
A
Y
SI
TA
T
HN
T
KN
HH
S
VA
TQ
NWG
N
S
TY
KQT
D
W
N
TSH
--
P
DF
AVS
RLDK
F
VVET
R
G
ATEGADISL
S
KQQ
ALERYG
VNY-KGE
K
KLIA
FRAGSG
VV
S
VKKN-
--
-----
-
-
-
-
---
G
RITPFNEVSYKP
E
M
L
N
-
G
S
FVH
I
DDWSGWL
-----
ILTN
N
Q
F
DE
F
N
N
IASQ
GDSGS
AL
F
V
YDN
QKK
KWV
V
A
G
-
-
T
VW
--
G
IYNYA
N
GKNH
A
AYSKW
N
QTTI
D
N
LK
NKYSYNV
D
---
----
-
-
-
-
-
M
S
G
AQVATIE
NG
K
LT
GTGSDTT--
-
-DIK
----
N---
-
KDL
I
F
T
G
G
-
G
D
I
L
LKSS
FDN
GAG
G
L
V
F
N
D
KKT
Y
R
V
NGDD
--
-F
TFKGAG
V
D
TRNGST
VEWN
IR
Y
DNK
DNLHKIG
D
GTL
D
V
RKT
--
Q
NT
NLK
T
GEG
L
VIL
GA
E
--
--
-
-
-
K
TFNNI
Y
I
T
SG
D
GTV
R
LN
AENA
L
S
-
GGE
Y
N
GI
F
F
AK
NGG
T
LDLNGYNQ
S
F
N
KIAATD
S
GA
V
ITN
T
-
ST
K
K
S
I
LSLN
-
------------------------------------------------------------------
----
-
----
-------
N
TAD
YIYHG
N
I
N
GNL
DVLQ
---
HHET--KKENRR
LILDG
G
VD
T
-
T
N
DISLR
N
TQ
L
S
MQGHAT
E
HA
IYRDG-AFSCSLPAPMR
FLCG
S
D
Y
V
AGMQNT
E
ADAV
K
QNGNAY
K
T
NN
A
V
S
DL
S
Q
P
DWETG
T
F
R
F
GT
L
H
L
E
NS
D
F
S
V
G
RNA
N
V
I
G
D
I
Q
A
-
SK
SNITIG
--
D
TT
AYID
LHA
GKNIT
G
DG
F
G
FRQNIVR
G
N
S
Q
--
---
GET
L
FTG
G
ITA
E
D
S
fig|478004.5.peg.4010
Escherichia coli O157:H7 str. EC4401 (1-713/1300)
MNKIYSLKYS
HI
TGGL
I
AVSEL
S
G
RV
SSR
A
T
G
KK
---
K
HKR
ILALCFLGLLQ----SSYSF
AS
Q
M
DISNF
Y
I
RDY
M
DFAQNKG
I
FQAGATNI
E
I
VK
K
D
G
STL
-
K
L
PEV
P
FP
DFS
P
V
A
--
N
----
K
G
S
T
T
S
IGG
A
Y
SI
TA
T
HN
T
KN
HH
S
VA
TQ
NWG
N
S
TY
KQT
D
W
N
TSH
--
P
DF
AVS
RLDK
F
VVET
R
G
ATEGADISL
S
KQQ
ALERYG
VNY-KGE
K
KLIA
FRAGSG
VV
S
VKKN-
--
-----
-
-
-
-
---
G
RITPFNEVSYKP
E
M
L
N
-
G
S
FVH
I
DDWSGWL
-----
ILTN
N
Q
F
DE
F
N
N
IASQ
GDSGS
AL
F
V
YDN
QKK
KWV
V
A
G
-
-
T
VW
--
G
IYNYA
N
GKNH
A
AYSKW
N
QTTI
D
N
LK
NKYSYNV
D
---
----
-
-
-
-
-
M
S
G
AQVATIE
NG
K
LT
GTGSDTT--
-
-DIK
----
N---
-
KDL
I
F
T
G
G
-
G
D
I
L
LKSS
FDN
GAG
G
L
V
F
N
D
KKT
Y
R
V
NGDD
--
-F
TFKGAG
V
D
TRNGST
VEWN
IR
Y
DNK
DNLHKIG
D
GTL
D
V
RKT
--
Q
NT
NLK
T
GEG
L
VIL
GA
E
--
--
-
-
-
K
TFNNI
Y
I
T
SG
D
GTV
R
LN
AENA
L
S
-
GGE
Y
N
GI
F
F
AK
NGG
T
LDLNGYNQ
S
F
N
KIAATD
S
GA
V
ITN
T
-
ST
K
K
S
I
LSLN
-
------------------------------------------------------------------
----
-
----
-------
N
TAD
YIYHG
N
I
N
GNL
DVLQ
---
HHET--KKENRR
LILDG
G
VD
T
-
T
N
DISLR
N
TQ
L
S
MQGHAT
E
HA
IYRDG-AFSCSLPAPMR
FLCG
S
D
Y
V
AGMQNT
E
ADAV
K
QNGNAY
K
T
NN
A
V
S
DL
S
Q
P
DWETG
T
F
R
F
GT
L
H
L
E
NS
D
F
S
V
G
RNA
N
V
I
G
D
I
Q
A
-
SK
SNITIG
--
D
TT
AYID
LHA
GKNIT
G
DG
F
G
FRQNIVR
G
N
S
Q
--
---
GET
L
FTG
G
ITA
E
D
S
fig|478005.5.peg.3232
Escherichia coli O157:H7 str. EC4486 (1-713/1300)
MNKIYSLKYS
HI
TGGL
I
AVSEL
S
G
RV
SSR
A
T
G
KK
---
K
HKR
ILALCFLGLLQ----SSYSF
AS
Q
M
DISNF
Y
I
RDY
M
DFAQNKG
I
FQAGATNI
E
I
VK
K
D
G
STL
-
K
L
PEV
P
FP
DFS
P
V
A
--
N
----
K
G
S
T
T
S
IGG
A
Y
SI
TA
T
HN
T
KN
HH
S
VA
TQ
NWG
N
S
TY
KQT
D
W
N
TSH
--
P
DF
AVS
RLDK
F
VVET
R
G
ATEGADISL
S
KQQ
ALERYG
VNY-KGE
K
KLIA
FRAGSG
VV
S
VKKN-
--
-----
-
-
-
-
---
G
RITPFNEVSYKP
E
M
L
N
-
G
S
FVH
I
DDWSGWL
-----
ILTN
N
Q
F
DE
F
N
N
IASQ
GDSGS
AL
F
V
YDN
QKK
KWV
V
A
G
-
-
T
VW
--
G
IYNYA
N
GKNH
A
AYSKW
N
QTTI
D
N
LK
NKYSYNV
D
---
----
-
-
-
-
-
M
S
G
AQVATIE
NG
K
LT
GTGSDTT--
-
-DIK
----
N---
-
KDL
I
F
T
G
G
-
G
D
I
L
LKSS
FDN
GAG
G
L
V
F
N
D
KKT
Y
R
V
NGDD
--
-F
TFKGAG
V
D
TRNGST
VEWN
IR
Y
DNK
DNLHKIG
D
GTL
D
V
RKT
--
Q
NT
NLK
T
GEG
L
VIL
GA
E
--
--
-
-
-
K
TFNNI
Y
I
T
SG
D
GTV
R
LN
AENA
L
S
-
GGE
Y
N
GI
F
F
AK
NGG
T
LDLNGYNQ
S
F
N
KIAATD
S
GA
V
ITN
T
-
ST
K
K
S
I
LSLN
-
------------------------------------------------------------------
----
-
----
-------
N
TAD
YIYHG
N
I
N
GNL
DVLQ
---
HHET--KKENRR
LILDG
G
VD
T
-
T
N
DISLR
N
TQ
L
S
MQGHAT
E
HA
IYRDG-AFSCSLPAPMR
FLCG
S
D
Y
V
AGMQNT
E
ADAV
K
QNGNAY
K
T
NN
A
V
S
DL
S
Q
P
DWETG
T
F
R
F
GT
L
H
L
E
NS
D
F
S
V
G
RNA
N
V
I
G
D
I
Q
A
-
SK
SNITIG
--
D
TT
AYID
LHA
GKNIT
G
DG
F
G
FRQNIVR
G
N
S
Q
--
---
GET
L
FTG
G
ITA
E
D
S
fig|478006.5.peg.3456
Escherichia coli O157:H7 str. EC4501 (1-713/1300)
MNKIYSLKYS
HI
TGGL
I
AVSEL
S
G
RV
SSR
A
T
G
KK
---
K
HKR
ILALCFLGLLQ----SSYSF
AS
Q
M
DISNF
Y
I
RDY
M
DFAQNKG
I
FQAGATNI
E
I
VK
K
D
G
STL
-
K
L
PEV
P
FP
DFS
P
V
A
--
N
----
K
G
S
T
T
S
IGG
A
Y
SI
TA
T
HN
T
KN
HH
S
VA
TQ
NWG
N
S
TY
KQT
D
W
N
TSH
--
P
DF
AVS
RLDK
F
VVET
R
G
ATEGADISL
S
KQQ
ALERYG
VNY-KGE
K
KLIA
FRAGSG
VV
S
VKKN-
--
-----
-
-
-
-
---
G
RITPFNEVSYKP
E
M
L
N
-
G
S
FVH
I
DDWSGWL
-----
ILTN
N
Q
F
DE
F
N
N
IASQ
GDSGS
AL
F
V
YDN
QKK
KWV
V
A
G
-
-
T
VW
--
G
IYNYA
N
GKNH
A
AYSKW
N
QTTI
D
N
LK
NKYSYNV
D
---
----
-
-
-
-
-
M
S
G
AQVATIE
NG
K
LT
GTGSDTT--
-
-DIK
----
N---
-
KDL
I
F
T
G
G
-
G
D
I
L
LKSS
FDN
GAG
G
L
V
F
N
D
KKT
Y
R
V
NGDD
--
-F
TFKGAG
V
D
TRNGST
VEWN
IR
Y
DNK
DNLHKIG
D
GTL
D
V
RKT
--
Q
NT
NLK
T
GEG
L
VIL
GA
E
--
--
-
-
-
K
TFNNI
Y
I
T
SG
D
GTV
R
LN
AENA
L
S
-
GGE
Y
N
GI
F
F
AK
NGG
T
LDLNGYNQ
S
F
N
KIAATD
S
GA
V
ITN
T
-
ST
K
K
S
I
LSLN
-
------------------------------------------------------------------
----
-
----
-------
N
TAD
YIYHG
N
I
N
GNL
DVLQ
---
HHET--KKENRR
LILDG
G
VD
T
-
T
N
DISLR
N
TQ
L
S
MQGHAT
E
HA
IYRDG-AFSCSLPAPMR
FLCG
S
D
Y
V
AGMQNT
E
ADAV
K
QNGNAY
K
T
NN
A
V
S
DL
S
Q
P
DWETG
T
F
R
F
GT
L
H
L
E
NS
D
F
S
V
G
RNA
N
V
I
G
D
I
Q
A
-
SK
SNITIG
--
D
TT
AYID
LHA
GKNIT
G
DG
F
G
FRQNIVR
G
N
S
Q
--
---
GET
L
FTG
G
ITA
E
D
S
fig|478007.5.peg.3850
Escherichia coli O157:H7 str. EC508 (1-713/1300)
MNKIYSLKYS
HI
TGGL
I
AVSEL
S
G
RV
SSR
A
T
G
KK
---
K
HKR
ILALCFLGLLQ----SSYSF
AS
Q
M
DISNF
Y
I
RDY
M
DFAQNKG
I
FQAGATNI
E
I
VK
K
D
G
STL
-
K
L
PEV
P
FP
DFS
P
V
A
--
N
----
K
G
S
T
T
S
IGG
A
Y
SI
TA
T
HN
T
KN
HH
S
VA
TQ
NWG
N
S
TY
KQT
D
W
N
TSH
--
P
DF
AVS
RLDK
F
VVET
R
G
ATEGADISL
S
KQQ
ALERYG
VNY-KGE
K
KLIA
FRAGSG
VV
S
VKKN-
--
-----
-
-
-
-
---
G
RITPFNEVSYKP
E
M
L
N
-
G
S
FVH
I
DDWSGWL
-----
ILTN
N
Q
F
DE
F
N
N
IASQ
GDSGS
AL
F
V
YDN
QKK
KWV
V
A
G
-
-
T
VW
--
G
IYNYA
N
GKNH
A
AYSKW
N
QTTI
D
N
LK
NKYSYNV
D
---
----
-
-
-
-
-
M
S
G
AQVATIE
NG
K
LT
GTGSDTT--
-
-DIK
----
N---
-
KDL
I
F
T
G
G
-
G
D
I
L
LKSS
FDN
GAG
G
L
V
F
N
D
KKT
Y
R
V
NGDD
--
-F
TFKGAG
V
D
TRNGST
VEWN
IR
Y
DNK
DNLHKIG
D
GTL
D
V
RKT
--
Q
NT
NLK
T
GEG
L
VIL
GA
E
--
--
-
-
-
K
TFNNI
Y
I
T
SG
D
GTV
R
LN
AENA
L
S
-
GGE
Y
N
GI
F
F
AK
NGG
T
LDLNGYNQ
S
F
N
KIAATD
S
GA
V
ITN
T
-
ST
K
K
S
I
LSLN
-
------------------------------------------------------------------
----
-
----
-------
N
TAD
YIYHG
N
I
N
GNL
DVLQ
---
HHET--KKENRR
LILDG
G
VD
T
-
T
N
DISLR
N
TQ
L
S
MQGHAT
E
HA
IYRDG-AFSCSLPAPMR
FLCG
S
D
Y
V
AGMQNT
E
ADAV
K
QNGNAY
K
T
NN
A
V
S
DL
S
Q
P
DWETG
T
F
R
F
GT
L
H
L
E
NS
D
F
S
V
G
RNA
N
V
I
G
D
I
Q
A
-
SK
SNITIG
--
D
TT
AYID
LHA
GKNIT
G
DG
F
G
FRQNIVR
G
N
S
Q
--
---
GET
L
FTG
G
ITA
E
D
S
fig|478007.5.peg.5210
Escherichia coli O157:H7 str. EC508 (1-713/1300)
MNKIYSLKYS
HI
TGGL
I
AVSEL
S
G
RV
SSR
A
T
G
KK
---
K
HKR
ILALCFLGLLQ----SSYSF
AS
Q
M
DISNF
Y
I
RDY
M
DFAQNKG
I
FQAGATNI
E
I
VK
K
D
G
STL
-
K
L
PEV
P
FP
DFS
P
V
A
--
N
----
K
G
S
T
T
S
IGG
A
Y
SI
TA
T
HN
T
KN
HH
S
VA
TQ
NWG
N
S
TY
KQT
D
W
N
TSH
--
P
DF
AVS
RLDK
F
VVET
R
G
ATEGADISL
S
KQQ
ALERYG
VNY-KGE
K
KLIA
FRAGSG
VV
S
VKKN-
--
-----
-
-
-
-
---
G
RITPFNEVSYKP
E
M
L
N
-
G
S
FVH
I
DDWSGWL
-----
ILTN
N
Q
F
DE
F
N
N
IASQ
GDSGS
AL
F
V
YDN
QKK
KWV
V
A
G
-
-
T
VW
--
G
IYNYA
N
GKNH
A
AYSKW
N
QTTI
D
N
LK
NKYSYNV
D
---
----
-
-
-
-
-
M
S
G
AQVATIE
NG
K
LT
GTGSDTT--
-
-DIK
----
N---
-
KDL
I
F
T
G
G
-
G
D
I
L
LKSS
FDN
GAG
G
L
V
F
N
D
KKT
Y
R
V
NGDD
--
-F
TFKGAG
V
D
TRNGST
VEWN
IR
Y
DNK
DNLHKIG
D
GTL
D
V
RKT
--
Q
NT
NLK
T
GEG
L
VIL
GA
E
--
--
-
-
-
K
TFNNI
Y
I
T
SG
D
GTV
R
LN
AENA
L
S
-
GGE
Y
N
GI
F
F
AK
NGG
T
LDLNGYNQ
S
F
N
KIAATD
S
GA
V
ITN
T
-
ST
K
K
S
I
LSLN
-
------------------------------------------------------------------
----
-
----
-------
N
TAD
YIYHG
N
I
N
GNL
DVLQ
---
HHET--KKENRR
LILDG
G
VD
T
-
T
N
DISLR
N
TQ
L
S
MQGHAT
E
HA
IYRDG-AFSCSLPAPMR
FLCG
S
D
Y
V
AGMQNT
E
ADAV
K
QNGNAY
K
T
NN
A
V
S
DL
S
Q
P
DWETG
T
F
R
F
GT
L
H
L
E
NS
D
F
S
V
G
RNA
N
V
I
G
D
I
Q
A
-
SK
SNITIG
--
D
TT
AYID
LHA
GKNIT
G
DG
F
G
FRQNIVR
G
N
S
Q
--
---
GET
L
FTG
G
ITA
E
D
S
fig|386585.9.peg.90
Escherichia coli O157:H7 str. Sakai (1-713/1300)
MNKIYSLKYS
HI
TGGL
I
AVSEL
S
G
RV
SSR
A
T
G
KK
---
K
HKR
ILALCFLGLLQ----SSYSF
AS
Q
M
DISNF
Y
I
RDY
M
DFAQNKG
I
FQAGATNI
E
I
VK
K
D
G
STL
-
K
L
PEV
P
FP
DFS
P
V
A
--
N
----
K
G
S
T
T
S
IGG
A
Y
SI
TA
T
HN
T
KN
HH
S
VA
TQ
NWG
N
S
TY
KQT
D
W
N
TSH
--
P
DF
AVS
RLDK
F
VVET
R
G
ATEGADISL
S
KQQ
ALERYG
VNY-KGE
K
KLIA
FRAGSG
VV
S
VKKN-
--
-----
-
-
-
-
---
G
RITPFNEVSYKP
E
M
L
N
-
G
S
FVH
I
DDWSGWL
-----
ILTN
N
Q
F
DE
F
N
N
IASQ
GDSGS
AL
F
V
YDN
QKK
KWV
V
A
G
-
-
T
VW
--
G
IYNYA
N
GKNH
A
AYSKW
N
QTTI
D
N
LK
NKYSYNV
D
---
----
-
-
-
-
-
M
S
G
AQVATIE
NG
K
LT
GTGSDTT--
-
-DIK
----
N---
-
KDL
I
F
T
G
G
-
G
D
I
L
LKSS
FDN
GAG
G
L
V
F
N
D
KKT
Y
R
V
NGDD
--
-F
TFKGAG
V
D
TRNGST
VEWN
IR
Y
DNK
DNLHKIG
D
GTL
D
V
RKT
--
Q
NT
NLK
T
GEG
L
VIL
GA
E
--
--
-
-
-
K
TFNNI
Y
I
T
SG
D
GTV
R
LN
AENA
L
S
-
GGE
Y
N
GI
F
F
AK
NGG
T
LDLNGYNQ
S
F
N
KIAATD
S
GA
V
ITN
T
-
ST
K
K
S
I
LSLN
-
------------------------------------------------------------------
----
-
----
-------
N
TAD
YIYHG
N
I
N
GNL
DVLQ
---
HHET--KKENRR
LILDG
G
VD
T
-
T
N
DISLR
N
TQ
L
S
MQGHAT
E
HA
IYRDG-AFSCSLPAPMR
FLCG
S
D
Y
V
AGMQNT
E
ADAV
K
QNGNAY
K
T
NN
A
V
S
DL
S
Q
P
DWETG
T
F
R
F
GT
L
H
L
E
NS
D
F
S
V
G
RNA
N
V
I
G
D
I
Q
A
-
SK
SNITIG
--
D
TT
AYID
LHA
GKNIT
G
DG
F
G
FRQNIVR
G
N
S
Q
--
---
GET
L
FTG
G
ITA
E
D
S
fig|544404.4.peg.5649
Escherichia coli O157:H7 str. TW14359 (1-713/1300)
MNKIYSLKYS
HI
TGGL
I
AVSEL
S
G
RV
SSR
A
T
G
KK
---
K
HKR
ILALCFLGLLQ----SSYSF
AS
Q
M
DISNF
Y
I
RDY
M
DFAQNKG
I
FQAGATNI
E
I
VK
K
D
G
STL
-
K
L
PEV
P
FP
DFS
P
V
A
--
N
----
K
G
S
T
T
S
IGG
A
Y
SI
TA
T
HN
T
KN
HH
S
VA
TQ
NWG
N
S
TY
KQT
D
W
N
TSH
--
P
DF
AVS
RLDK
F
VVET
R
G
ATEGADISL
S
KQQ
ALERYG
VNY-KGE
K
KLIA
FRAGSG
VV
S
VKKN-
--
-----
-
-
-
-
---
G
RITPFNEVSYKP
E
M
L
N
-
G
S
FVH
I
DDWSGWL
-----
ILTN
N
Q
F
DE
F
N
N
IASQ
GDSGS
AL
F
V
YDN
QKK
KWV
V
A
G
-
-
T
VW
--
G
IYNYA
N
GKNH
A
AYSKW
N
QTTI
D
N
LK
NKYSYNV
D
---
----
-
-
-
-
-
M
S
G
AQVATIE
NG
K
LT
GTGSDTT--
-
-DIK
----
N---
-
KDL
I
F
T
G
G
-
G
D
I
L
LKSS
FDN
GAG
G
L
V
F
N
D
KKT
Y
R
V
NGDD
--
-F
TFKGAG
V
D
TRNGST
VEWN
IR
Y
DNK
DNLHKIG
D
GTL
D
V
RKT
--
Q
NT
NLK
T
GEG
L
VIL
GA
E
--
--
-
-
-
K
TFNNI
Y
I
T
SG
D
GTV
R
LN
AENA
L
S
-
GGE
Y
N
GI
F
F
AK
NGG
T
LDLNGYNQ
S
F
N
KIAATD
S
GA
V
ITN
T
-
ST
K
K
S
I
LSLN
-
------------------------------------------------------------------
----
-
----
-------
N
TAD
YIYHG
N
I
N
GNL
DVLQ
---
HHET--KKENRR
LILDG
G
VD
T
-
T
N
DISLR
N
TQ
L
S
MQGHAT
E
HA
IYRDG-AFSCSLPAPMR
FLCG
S
D
Y
V
AGMQNT
E
ADAV
K
QNGNAY
K
T
NN
A
V
S
DL
S
Q
P
DWETG
T
F
R
F
GT
L
H
L
E
NS
D
F
S
V
G
RNA
N
V
I
G
D
I
Q
A
-
SK
SNITIG
--
D
TT
AYID
LHA
GKNIT
G
DG
F
G
FRQNIVR
G
N
S
Q
--
---
GET
L
FTG
G
ITA
E
D
S
fig|502346.5.peg.5699
Escherichia coli O157:H7 str. TW14588 (1-713/1300)
MNKIYSLKYS
HI
TGGL
I
AVSEL
S
G
RV
SSR
A
T
G
KK
---
K
HKR
ILALCFLGLLQ----SSYSF
AS
Q
M
DISNF
Y
I
RDY
M
DFAQNKG
I
FQAGATNI
E
I
VK
K
D
G
STL
-
K
L
PEV
P
FP
DFS
P
V
A
--
N
----
K
G
S
T
T
S
IGG
A
Y
SI
TA
T
HN
T
KN
HH
S
VA
TQ
NWG
N
S
TY
KQT
D
W
N
TSH
--
P
DF
AVS
RLDK
F
VVET
R
G
ATEGADISL
S
KQQ
ALERYG
VNY-KGE
K
KLIA
FRAGSG
VV
S
VKKN-
--
-----
-
-
-
-
---
G
RITPFNEVSYKP
E
M
L
N
-
G
S
FVH
I
DDWSGWL
-----
ILTN
N
Q
F
DE
F
N
N
IASQ
GDSGS
AL
F
V
YDN
QKK
KWV
V
A
G
-
-
T
VW
--
G
IYNYA
N
GKNH
A
AYSKW
N
QTTI
D
N
LK
NKYSYNV
D
---
----
-
-
-
-
-
M
S
G
AQVATIE
NG
K
LT
GTGSDTT--
-
-DIK
----
N---
-
KDL
I
F
T
G
G
-
G
D
I
L
LKSS
FDN
GAG
G
L
V
F
N
D
KKT
Y
R
V
NGDD
--
-F
TFKGAG
V
D
TRNGST
VEWN
IR
Y
DNK
DNLHKIG
D
GTL
D
V
RKT
--
Q
NT
NLK
T
GEG
L
VIL
GA
E
--
--
-
-
-
K
TFNNI
Y
I
T
SG
D
GTV
R
LN
AENA
L
S
-
GGE
Y
N
GI
F
F
AK
NGG
T
LDLNGYNQ
S
F
N
KIAATD
S
GA
V
ITN
T
-
ST
K
K
S
I
LSLN
-
------------------------------------------------------------------
----
-
----
-------
N
TAD
YIYHG
N
I
N
GNL
DVLQ
---
HHET--KKENRR
LILDG
G
VD
T
-
T
N
DISLR
N
TQ
L
S
MQGHAT
E
HA
IYRDG-AFSCSLPAPMR
FLCG
S
D
Y
V
AGMQNT
E
ADAV
K
QNGNAY
K
T
NN
A
V
S
DL
S
Q
P
DWETG
T
F
R
F
GT
L
H
L
E
NS
D
F
S
V
G
RNA
N
V
I
G
D
I
Q
A
-
SK
SNITIG
--
D
TT
AYID
LHA
GKNIT
G
DG
F
G
FRQNIVR
G
N
S
Q
--
---
GET
L
FTG
G
ITA
E
D
S
fig|478008.5.peg.4927
Escherichia coli O157:H7 str. EC869 (1-713/1300)
MNKIYSLKYS
HI
TGGL
I
AVSEL
S
G
RV
SSR
A
T
G
KK
---
K
HKR
ILALCFLGLLQ----SSYSF
AS
Q
M
DISNF
Y
I
RDY
M
DFAQNKG
I
FQAGATNI
E
I
VK
K
D
G
STL
-
K
L
PEV
P
FP
DFS
P
V
A
--
N
----
K
G
S
T
T
S
IGG
A
Y
SI
TA
T
HN
T
KN
HH
S
VA
TQ
NWG
N
S
TY
KQT
D
W
N
TSH
--
P
DF
AVS
RLDK
F
VVET
R
G
ATEGADISL
S
KQQ
ALERYG
VNY-KGE
K
KLIA
FRAGSG
VV
S
VKKN-
--
-----
-
-
-
-
---
G
RITPFNEVSYKP
E
M
L
N
-
G
S
FVH
I
DDWSGWL
-----
ILTN
N
Q
F
DE
F
N
N
IASQ
GDSGS
AL
F
V
YDN
QKK
KWV
V
A
G
-
-
T
VW
--
G
IYNYA
N
GKNH
A
AYSKW
N
QTTI
D
N
LK
NKYSYNV
D
---
----
-
-
-
-
-
M
S
G
AQVATIE
NG
K
LT
GTGSDTT--
-
-DIK
----
N---
-
KDL
I
F
T
G
G
-
G
D
I
L
LKSS
FDN
GAG
G
L
V
F
N
D
KKT
Y
R
V
NGDD
--
-F
TFKGAG
V
D
TRNGST
VEWN
IR
Y
DNK
DNLHKIG
D
GTL
D
V
RKT
--
Q
NT
NLK
T
GEG
L
VIL
GA
E
--
--
-
-
-
K
TFNNI
Y
I
T
SG
D
GTV
R
LN
AENA
L
S
-
GGE
Y
N
GI
F
F
AK
NGG
T
LDLNGYNQ
S
F
N
KIAATD
S
GA
I
ITN
T
-
ST
K
K
S
I
LSLN
-
------------------------------------------------------------------
----
-
----
-------
N
TAD
YIYHG
N
I
N
GNL
DVLQ
---
HHET--KKENRR
LILDG
G
VD
T
-
T
N
DISLR
N
TQ
L
S
MQGHAT
E
HA
IYRDG-AFSCSLPAPMR
FLCG
S
D
Y
V
AGMQNT
E
ADAV
K
QNGNAY
K
T
NN
A
V
S
DL
S
Q
P
DWETG
T
F
R
F
GT
L
H
L
E
NS
D
F
S
V
G
RNA
N
V
I
G
D
I
Q
A
-
SK
SNITIG
--
D
TT
AYID
LHA
GKNIT
G
DG
F
G
FRQNIVR
G
S
S
Q
--
---
GET
L
FTG
G
ITA
E
D
S
fig|637388.3.peg.3563
Escherichia coli O157:H7 str. FRIK2000 (1-713/1300)
MNKIYSLKYS
HI
TGGL
I
AVSEL
S
G
RV
SSR
A
T
G
KK
---
K
HKR
ILALCFLGLLQ----SSYSF
AS
Q
M
DISNF
Y
I
RDY
M
DFAQNKG
I
FQAGATNI
E
I
VK
K
D
G
STL
-
K
L
PEV
P
FP
DFS
P
V
A
--
N
----
K
G
S
T
T
S
IGG
A
Y
SI
TA
T
HN
T
KN
HH
S
VA
TQ
NWG
N
S
TY
KQT
D
W
N
TSH
--
P
DF
AVS
RLDK
F
VVET
R
G
ATEGADISL
S
KQQ
ALERYG
VNY-KGE
K
KLIA
FRAGSG
VV
S
VKKN-
--
-----
-
-
-
-
---
G
RITPFNEVSYKP
E
M
L
N
-
G
S
FVH
I
DDWSGWL
-----
ILTN
N
Q
F
DE
F
N
N
IASQ
GDSGS
AL
F
V
YDN
QKK
KWV
V
A
G
-
-
T
VW
--
G
IYNYA
N
GKNH
A
AYSKW
N
QTTI
D
N
LK
NKYSYNV
D
---
----
-
-
-
-
-
M
S
G
AQVATIE
NG
K
LT
GTGSDTT--
-
-DIK
----
N---
-
KDL
I
F
T
G
G
-
G
D
I
L
LKSS
FDN
GAG
G
L
V
F
N
D
KKT
Y
R
V
NGDD
--
-F
TFKGAG
V
D
TRNGST
VEWN
IR
Y
DNK
DNLHKIG
D
GTL
D
V
RKT
--
Q
NT
NLK
T
GEG
L
VIL
GA
E
--
--
-
-
-
K
TFNNI
Y
I
T
SG
D
GTV
R
LN
AENA
L
S
-
GGE
Y
N
GI
F
F
AK
NGG
T
LDLNGYNQ
S
F
N
KIAATD
S
GA
I
ITN
T
-
ST
K
K
S
I
LSLN
-
------------------------------------------------------------------
----
-
----
-------
N
TAD
YIYHG
N
I
N
GNL
DVLQ
---
HHET--KKENRR
LILDG
G
VD
T
-
T
N
DISLR
N
TQ
L
S
MQGHAT
E
HA
IYRDG-AFSCSLPAPMR
FLCG
S
D
Y
V
AGMQNT
E
ADAV
K
QNGNAY
K
T
NN
A
V
S
DL
S
Q
P
DWETG
T
F
R
F
GT
L
H
L
E
NS
D
F
S
V
G
RNA
N
V
I
G
D
I
Q
A
-
SK
SNITIG
--
D
TT
AYID
LHA
GKNIT
G
DG
F
G
FRQNIVR
G
S
S
Q
--
---
GET
L
FTG
G
ITA
E
D
S
fig|570506.3.peg.2737
Escherichia coli O157:H7 str. FRIK966 (1-713/1300)
MNKIYSLKYS
HI
TGGL
I
AVSEL
S
G
RV
SSR
A
T
G
KK
---
K
HKR
ILALCFLGLLQ----SSYSF
AS
Q
M
DISNF
Y
I
RDY
M
DFAQNKG
I
FQAGATNI
E
I
VK
K
D
G
STL
-
K
L
PEV
P
FP
DFS
P
V
A
--
N
----
K
G
S
T
T
S
IGG
A
Y
SI
TA
T
HN
T
KN
HH
S
VA
TQ
NWG
N
S
TY
KQT
D
W
N
TSH
--
P
DF
AVS
RLDK
F
VVET
R
G
ATEGADISL
S
KQQ
ALERYG
VNY-KGE
K
KLIA
FRAGSG
VV
S
VKKN-
--
-----
-
-
-
-
---
G
RITPFNEVSYKP
E
M
L
N
-
G
S
FVH
I
DDWSGWL
-----
ILTN
N
Q
F
DE
F
N
N
IASQ
GDSGS
AL
F
V
YDN
QKK
KWV
V
A
G
-
-
T
VW
--
G
IYNYA
N
GKNH
A
AYSKW
N
QTTI
D
N
LK
NKYSYNV
D
---
----
-
-
-
-
-
M
S
G
AQVATIE
NG
K
LT
GTGSDTT--
-
-DIK
----
N---
-
KDL
I
F
T
G
G
-
G
D
I
L
LKSS
FDN
GAG
G
L
V
F
N
D
KKT
Y
R
V
NGDD
--
-F
TFKGAG
V
D
TRNGST
VEWN
IR
Y
DNK
DNLHKIG
D
GTL
D
V
RKT
--
Q
NT
NLK
T
GEG
L
VIL
GA
E
--
--
-
-
-
K
TFNNI
Y
I
T
SG
D
GTV
R
LN
AENA
L
S
-
GGE
Y
N
GI
F
F
AK
NGG
T
LDLNGYNQ
S
F
N
KIAATD
S
GA
I
ITN
T
-
ST
K
K
S
I
LSLN
-
------------------------------------------------------------------
----
-
----
-------
N
TAD
YIYHG
N
I
N
GNL
DVLQ
---
HHET--KKENRR
LILDG
G
VD
T
-
T
N
DISLR
N
TQ
L
S
MQGHAT
E
HA
IYRDG-AFSCSLPAPMR
FLCG
S
D
Y
V
AGMQNT
E
ADAV
K
QNGNAY
K
T
NN
A
V
S
DL
S
Q
P
DWETG
T
F
R
F
GT
L
H
L
E
NS
D
F
S
V
G
RNA
N
V
I
G
D
I
Q
A
-
SK
SNITIG
--
D
TT
AYID
LHA
GKNIT
G
DG
F
G
FRQNIVR
G
S
S
Q
--
---
GET
L
FTG
G
ITA
E
D
S
fig|216592.1.peg.5179
Escherichia coli 042 (5-715/1299)
MNKIYS
I
KYS
AA
TGGL
I
AVSELA
K
K
V
ICK
T
N
R
KI
---
-
---
SAALLSLAVISY---TNIIY
A
A
N
M
DISKA
W
A
RDY
L
D
L
AQNKG
V
FQ
P
G
S
T
H
V
K
I
KL
K
D
G
TDF
-
S
F
PAL
P
VP
DFS
S
A
T
--
A
----
N
G
A
AT
S
IGG
A
Y
AV
T
V
A
HN
A
KN
KS
S
AN
Y
Q
TYG
S
T
Q
Y
TQI
N
R
M
TTG
--
N
DF
SIQ
RL
N
K
Y
VVET
R
G
ADTSFNYNE
N
NQN
I
ID
RYG
VDVGNGK
K
EIIG
FR
V
GSG
NT
T
F----
--
-----
-
-
-
-
---
-
SGIKTSQT-YQA
D
L
L
S
-
A
S
LFH
I
TNLRANT
VGGNK
VEYE
N
D
-
SY
F
T
N
LTTN
GDSGS
GV
Y
V
F
DN
KED
KWVL
L
G
-
-
T
TH
--
G
IIG-N
G
KTQK
T
YVTPF
D
SKTT
N
E
LK
QLFIQNV
N
---
----
-
-
-
-
-
I
D
N
-NTATIG
G
G
K
I
T
IGNTTQDI-
-
EKNK
----
NNQN
-
KDL
V
F
S
G
G
-
G
K
I
S
LK
E
N
LDL
G
Y
G
G
F
I
F
D
E
NKK
Y
T
V
SAEG
NN
NV
TFKGAGID
IGKGST
V
D
WN
IK
Y
ASN
D
A
LHKIG
E
G
S
L
N
V
IQA
--
Q
NT
NLK
T
G
N
G
T
VIL
GA
Q
--
--
-
-
-
K
TFNNI
Y
V
A
G
G
P
GTV
Q
LN
AENA
L
G
-
EGD
Y
A
GI
F
F
TE
NGG
K
LDLNG
H
NQTF
K
KIAATD
S
G
T
T
ITNS
N
TT
K
E
S
V
LS
V
N
-
------------------------------------------------------------------
----
-
----
-------
N
QNN
YIYHG
N
V
D
GN
V
RLEH
---
HLDT--KQDNAR
LILDG
D
I
Q
A
-
-
N
SISIK
N
AP
L
V
MQGHAT
D
HA
IFRTTKTNNCP-E----
FLCG
V
D
W
V
TRIKNA
E
NSVN
Q
KNKTTY
K
S
NNQ
V
S
DL
S
Q
P
DWET
R
K
F
R
F
DN
L
N
I
E
D
S
S
L
S
I
A
RNA
D
V
E
G
N
I
Q
A
-
KN
S
V
I
N
IG
--
D
KT
AYID
LYS
GKNIT
G
A
G
F
T
FRQDIKS
G
D
S
I
--
---
GE
S
K
FTG
G
I
M
A
T
D
fig|216592.3.peg.5129
Escherichia coli 042 (1-711/1295)
MNKIYS
I
KYS
AA
TGGL
I
AVSELA
K
K
V
ICK
T
N
R
KI
---
-
---
SAALLSLAVISY---TNIIY
A
A
N
M
DISKA
W
A
RDY
L
D
L
AQNKG
V
FQ
P
G
S
T
H
V
K
I
KL
K
D
G
TDF
-
S
F
PAL
P
VP
DFS
S
A
T
--
A
----
N
G
A
AT
S
IGG
A
Y
AV
T
V
A
HN
A
KN
KS
S
AN
Y
Q
TYG
S
T
Q
Y
TQI
N
R
M
TTG
--
N
DF
SIQ
RL
N
K
Y
VVET
R
G
ADTSFNYNE
N
NQN
I
ID
RYG
VDVGNGK
K
EIIG
FR
V
GSG
NT
T
F----
--
-----
-
-
-
-
---
-
SGIKTSQT-YQA
D
L
L
S
-
A
S
LFH
I
TNLRANT
VGGNK
VEYE
N
D
-
SY
F
T
N
LTTN
GDSGS
GV
Y
V
F
DN
KED
KWVL
L
G
-
-
T
TH
--
G
IIG-N
G
KTQK
T
YVTPF
D
SKTT
N
E
LK
QLFIQNV
N
---
----
-
-
-
-
-
I
D
N
-NTATIG
G
G
K
I
T
IGNTTQDI-
-
EKNK
----
NNQN
-
KDL
V
F
S
G
G
-
G
K
I
S
LK
E
N
LDL
G
Y
G
G
F
I
F
D
E
NKK
Y
T
V
SAEG
NN
NV
TFKGAGID
IGKGST
V
D
WN
IK
Y
ASN
D
A
LHKIG
E
G
S
L
N
V
IQA
--
Q
NT
NLK
T
G
N
G
T
VIL
GA
Q
--
--
-
-
-
K
TFNNI
Y
V
A
G
G
P
GTV
Q
LN
AENA
L
G
-
EGD
Y
A
GI
F
F
TE
NGG
K
LDLNG
H
NQTF
K
KIAATD
S
G
T
T
ITNS
N
TT
K
E
S
V
LS
V
N
-
------------------------------------------------------------------
----
-
----
-------
N
QNN
YIYHG
N
V
D
GN
V
RLEH
---
HLDT--KQDNAR
LILDG
D
I
Q
A
-
-
N
SISIK
N
AP
L
V
MQGHAT
D
HA
IFRTTKTNNCP-E----
FLCG
V
D
W
V
TRIKNA
E
NSVN
Q
KNKTTY
K
S
NNQ
V
S
DL
S
Q
P
DWET
R
K
F
R
F
DN
L
N
I
E
D
S
S
L
S
I
A
RNA
D
V
E
G
N
I
Q
A
-
KN
S
V
I
N
IG
--
D
KT
AYID
LYS
GKNIT
G
A
G
F
T
FRQDIKS
G
D
S
I
--
---
GE
S
K
FTG
G
I
M
A
T
D
fig|199310.1.peg.3537
Escherichia coli CFT073 (5-715/1299)
MNKIYSLKYS
AA
TGGL
I
AVSELA
K
RV
SGK
T
N
R
KL
---
-
---
VATMLSLAVAGT---VN---
A
A
N
I
DISNV
W
A
RDY
L
D
L
AQNKG
I
FQ
P
GAT
DV
T
I
TL
K
N
G
DKF
-
S
F
HNL
S
IP
DFS
G
A
A
--
A
----
S
G
A
AT
A
IGG
S
Y
SV
T
V
A
HN
K
KN
PQ
A
AE
TQ
VYA
Q
S
S
Y
RVV
D
R
R
NS-
--
N
DF
EIQ
RL
N
K
F
VVET
V
G
ATPAETNPT
T
YSD
ALERYG
IVTSDGS
K
KIIG
FRAGSG
GT
S
FING-
--
-----
-
-
-
-
---
E
SKISTNSA-YSH
D
L
L
S
-
A
S
LFE
V
TQWDSYG
M
----
MIYK
N
D
-
KT
F
R
N
LEIF
GDSGS
GA
Y
L
YDN
KLE
KWVL
V
G
-
-
T
TH
--
G
IAS-V
N
GDQL
T
WITKY
N
DKLV
S
E
LK
DTYSHKI
N
---
----
-
-
-
-
-
L
N
G
-NNVTIK
N
T
D
I
T
LHQNNADTT
G
TQEK
----
ITKD
-
KD
I
V
F
T
N
G
-
G
D
V
L
F
K
D
N
LDF
G
S
G
G
I
I
F
D
E
GHE
Y
N
I
NGQG
--
-F
TFKGAGID
IGKESI
V
N
WN
AL
Y
SSD
D
V
LHKIG
P
GTL
N
V
QKK
--
Q
GA
N
I
K
I
GEG
N
VIL
NE
E
--
--
-
-
-
G
TFNNI
Y
L
ASG
N
G
K
V
I
LN
KDNS
L
G
-
NDQ
Y
A
GI
F
F
TK
R
GG
T
LDLNG
H
NQTF
T
R
IAATD
D
G
T
T
ITNS
D
TT
K
E
A
V
L
A
I
N
-
------------------------------------------------------------------
----
-
----
-------
N
EDS
YIYHG
N
I
N
GN
I
KLTH
---
NINSQDKKTNAK
LILDG
S
V
N
T
-
K
N
DVEVS
N
AS
L
T
MQGHAT
E
HA
IFRSS-ANHCSLV----
FLCG
T
D
W
V
TVLKET
E
SSYN
K
KFNSDY
K
S
NNQ
Q
T
SF
D
Q
P
DW
K
TG
V
F
K
F
DT
L
H
L
N
N
A
D
F
S
I
S
RNA
N
V
E
G
N
I
S
A
-
NK
S
A
ITIG
--
D
KN
V
YID
NLA
GKNIT
N
N
G
F
D
FKQTIST
N
L
S
I
--
---
GET
K
FTG
G
ITA
H
NS
Q
fig|199310.4.peg.3407
Escherichia coli CFT073 (1-711/1295)
MNKIYSLKYS
AA
TGGL
I
AVSELA
K
RV
SGK
T
N
R
KL
---
-
---
VATMLSLAVAGT---VN---
A
A
N
I
DISNV
W
A
RDY
L
D
L
AQNKG
I
FQ
P
GAT
DV
T
I
TL
K
N
G
DKF
-
S
F
HNL
S
IP
DFS
G
A
A
--
A
----
S
G
A
AT
A
IGG
S
Y
SV
T
V
A
HN
K
KN
PQ
A
AE
TQ
VYA
Q
S
S
Y
RVV
D
R
R
NS-
--
N
DF
EIQ
RL
N
K
F
VVET
V
G
ATPAETNPT
T
YSD
ALERYG
IVTSDGS
K
KIIG
FRAGSG
GT
S
FING-
--
-----
-
-
-
-
---
E
SKISTNSA-YSH
D
L
L
S
-
A
S
LFE
V
TQWDSYG
M
----
MIYK
N
D
-
KT
F
R
N
LEIF
GDSGS
GA
Y
L
YDN
KLE
KWVL
V
G
-
-
T
TH
--
G
IAS-V
N
GDQL
T
WITKY
N
DKLV
S
E
LK
DTYSHKI
N
---
----
-
-
-
-
-
L
N
G
-NNVTIK
N
T
D
I
T
LHQNNADTT
G
TQEK
----
ITKD
-
KD
I
V
F
T
N
G
-
G
D
V
L
F
K
D
N
LDF
G
S
G
G
I
I
F
D
E
GHE
Y
N
I
NGQG
--
-F
TFKGAGID
IGKESI
V
N
WN
AL
Y
SSD
D
V
LHKIG
P
GTL
N
V
QKK
--
Q
GA
N
I
K
I
GEG
N
VIL
NE
E
--
--
-
-
-
G
TFNNI
Y
L
ASG
N
G
K
V
I
LN
KDNS
L
G
-
NDQ
Y
A
GI
F
F
TK
R
GG
T
LDLNG
H
NQTF
T
R
IAATD
D
G
T
T
ITNS
D
TT
K
E
A
V
L
A
I
N
-
------------------------------------------------------------------
----
-
----
-------
N
EDS
YIYHG
N
I
N
GN
I
KLTH
---
NINSQDKKTNAK
LILDG
S
V
N
T
-
K
N
DVEVS
N
AS
L
T
MQGHAT
E
HA
IFRSS-ANHCSLV----
FLCG
T
D
W
V
TVLKET
E
SSYN
K
KFNSDY
K
S
NNQ
Q
T
SF
D
Q
P
DW
K
TG
V
F
K
F
DT
L
H
L
N
N
A
D
F
S
I
S
RNA
N
V
E
G
N
I
S
A
-
NK
S
A
ITIG
--
D
KN
V
YID
NLA
GKNIT
N
N
G
F
D
FKQTIST
N
L
S
I
--
---
GET
K
FTG
G
ITA
H
NS
Q
fig|656379.3.peg.4405
Escherichia coli FVEC1302 (1-711/1295)
MNKIYSLKYS
AA
TGGL
I
AVSELA
K
RV
SGK
T
N
R
KL
---
-
---
VATMLSLAVAGT---VN---
A
A
N
I
DISNV
W
A
RDY
L
D
L
AQNKG
I
FQ
P
GAT
DV
T
I
TL
K
N
G
DKF
-
S
F
HNL
S
IP
DFS
G
A
A
--
A
----
S
G
A
AT
A
IGG
S
Y
SV
T
V
A
HN
K
KN
PQ
A
AE
TQ
VYA
Q
S
S
Y
RVV
D
R
R
NS-
--
N
DF
EIQ
RL
N
K
F
VVET
V
G
ATPAETNPT
T
YSD
ALERYG
IVTSDGS
K
KIIG
FRAGSG
GT
S
FING-
--
-----
-
-
-
-
---
E
SKISTNSA-YSH
D
L
L
S
-
A
S
LFE
V
TQWDSYG
M
----
MIYK
N
D
-
KT
F
R
N
LEIF
GDSGS
GA
Y
L
YDN
KLE
KWVL
V
G
-
-
T
TH
--
G
IAS-V
N
GDQL
T
WITKY
N
DKLV
S
E
LK
DTYSHKI
N
---
----
-
-
-
-
-
L
N
G
-NNVTIK
N
T
D
I
T
LHQNNADTT
G
TQEK
----
ITKD
-
KD
I
V
F
T
N
G
-
G
D
V
L
F
K
D
N
LDF
G
S
G
G
I
I
F
D
E
GHE
Y
N
I
NGQG
--
-F
TFKGAGID
IGKESI
V
N
WN
AL
Y
SSD
D
V
LHKIG
P
GTL
N
V
QKK
--
Q
GA
N
I
K
I
GEG
N
VIL
NE
E
--
--
-
-
-
G
TFNNI
Y
L
ASG
N
G
K
V
I
LN
KDNS
L
G
-
NDQ
Y
A
GI
F
F
TK
R
GG
T
LDLNG
H
NQTF
T
R
IAATD
D
G
T
T
ITNS
D
TT
K
E
A
V
L
A
I
N
-
------------------------------------------------------------------
----
-
----
-------
N
EDS
YIYHG
N
I
N
GN
I
KLTH
---
NINSQDKKTNAK
LILDG
S
V
N
T
-
K
N
DVEVS
N
AS
L
T
MQGHAT
E
HA
IFRSS-ANHCSLV----
FLCG
T
D
W
V
TVLKET
E
SSYN
K
KFNSDY
K
S
NNQ
Q
T
SF
D
Q
P
DW
K
TG
V
F
K
F
DT
L
H
L
N
N
A
D
F
S
I
S
RNA
N
V
E
G
N
I
S
A
-
NK
S
A
ITIG
--
D
KN
V
YID
NLA
GKNIT
N
N
G
F
D
FKQTIST
N
L
S
I
--
---
GET
K
FTG
G
ITA
H
NS
Q
fig|656380.3.peg.4320
Escherichia coli FVEC1412 (1-711/1295)
MNKIYSLKYS
AA
TGGL
I
AVSELA
K
RV
SGK
T
N
R
KL
---
-
---
VATMLSLAVAGT---VN---
A
A
N
I
DISNV
W
A
RDY
L
D
L
AQNKG
I
FQ
P
GAT
DV
T
I
TL
K
N
G
DKF
-
S
F
HNL
S
IP
DFS
G
A
A
--
A
----
S
G
A
AT
A
IGG
S
Y
SV
T
V
A
HN
K
KN
PQ
A
AE
TQ
VYA
Q
S
S
Y
RVV
D
R
R
NS-
--
N
DF
EIQ
RL
N
K
F
VVET
V
G
ATPAETNPT
T
YSD
ALERYG
IVTSDGS
K
KIIG
FRAGSG
GT
S
FING-
--
-----
-
-
-
-
---
E
SKISTNSA-YSH
D
L
L
S
-
A
S
LFE
V
TQWDSYG
M
----
MIYK
N
D
-
KT
F
R
N
LEIF
GDSGS
GA
Y
L
YDN
KLE
KWVL
V
G
-
-
T
TH
--
G
IAS-V
N
GDQL
T
WITKY
N
DKLV
S
E
LK
DTYSHKI
N
---
----
-
-
-
-
-
L
N
G
-NNVTIK
N
T
D
I
T
LHQNNADTT
G
TQEK
----
ITKD
-
KD
I
V
F
T
N
G
-
G
D
V
L
F
K
D
N
LDF
G
S
G
G
I
I
F
D
E
GHE
Y
N
I
NGQG
--
-F
TFKGAGID
IGKESI
V
N
WN
AL
Y
SSD
D
V
LHKIG
P
GTL
N
V
QKK
--
Q
GA
N
I
K
I
GEG
N
VIL
NE
E
--
--
-
-
-
G
TFNNI
Y
L
ASG
N
G
K
V
I
LN
KDNS
L
G
-
NDQ
Y
A
GI
F
F
TK
R
GG
T
LDLNG
H
NQTF
T
R
IAATD
D
G
T
T
ITNS
D
TT
K
E
A
V
L
A
I
N
-
------------------------------------------------------------------
----
-
----
-------
N
EDS
YIYHG
N
I
N
GN
I
KLTH
---
NINSQDKKTNAK
LILDG
S
V
N
T
-
K
N
DVEVS
N
AS
L
T
MQGHAT
E
HA
IFRSS-ANHCSLV----
FLCG
T
D
W
V
TVLKET
E
SSYN
K
KFNSDY
K
S
NNQ
Q
T
SF
D
Q
P
DW
K
TG
V
F
K
F
DT
L
H
L
N
N
A
D
F
S
I
S
RNA
N
V
E
G
N
I
S
A
-
NK
S
A
ITIG
--
D
KN
V
YID
NLA
GKNIT
N
N
G
F
D
FKQTIST
N
L
S
I
--
---
GET
K
FTG
G
ITA
H
NS
Q
fig|749549.3.peg.23
Escherichia coli MS 198-1 (1-711/1295)
MNKIYSLKYS
AA
TGGL
I
AVSELA
K
RV
SGK
T
N
R
KL
---
-
---
VATMLSLAVAGT---VN---
A
A
N
I
DISNV
W
A
RDY
L
D
L
AQNKG
I
FQ
P
GAT
DV
T
I
TL
K
N
G
DKF
-
S
F
HNL
S
IP
DFS
G
A
A
--
A
----
S
G
A
AT
A
IGG
S
Y
SV
T
V
A
HN
K
KN
PQ
A
AE
TQ
VYA
Q
S
S
Y
RVV
D
R
R
NS-
--
N
DF
EIQ
RL
N
K
F
VVET
V
G
ATPAETNPT
T
YSD
ALERYG
IVTSDGS
K
KIIG
FRAGSG
GT
S
FING-
--
-----
-
-
-
-
---
E
SKISTNSA-YSH
D
L
L
S
-
A
S
LFE
V
TQWDSYG
M
----
MIYK
N
D
-
KT
F
R
N
LEIF
GDSGS
GA
Y
L
YDN
KLE
KWVL
V
G
-
-
T
TH
--
G
IAS-V
N
GDQL
T
WITKY
N
DKLV
S
E
LK
DTYSHKI
N
---
----
-
-
-
-
-
L
N
G
-NNVTIK
N
T
D
I
T
LHQNNADTT
G
TQEK
----
ITKD
-
KD
I
V
F
T
N
G
-
G
D
V
L
F
K
D
N
LDF
G
S
G
G
I
I
F
D
E
GHE
Y
N
I
NGQG
--
-F
TFKGAGID
IGKESI
V
N
WN
AL
Y
SSD
D
V
LHKIG
P
GTL
N
V
QKK
--
Q
GA
N
I
K
I
GEG
N
VIL
NE
E
--
--
-
-
-
G
TFNNI
Y
L
ASG
N
G
K
V
I
LN
KDNS
L
G
-
NDQ
Y
A
GI
F
F
TK
R
GG
T
LDLNG
H
NQTF
T
R
IAATD
D
G
T
T
ITNS
D
TT
K
E
A
V
L
A
I
N
-
------------------------------------------------------------------
----
-
----
-------
N
EDS
YIYHG
N
I
N
GN
I
KLTH
---
NINSQDKKTNAK
LILDG
S
V
N
T
-
K
N
DVEVS
N
AS
L
T
MQGHAT
E
HA
IFRSS-ANHCSLV----
FLCG
T
D
W
V
TVLKET
E
SSYN
K
KFNSDY
K
S
NNQ
Q
T
SF
D
Q
P
DW
K
TG
V
F
K
F
DT
L
H
L
N
N
A
D
F
S
I
S
RNA
N
V
E
G
N
I
S
A
-
NK
S
A
ITIG
--
D
KN
V
YID
NLA
GKNIT
N
N
G
F
D
FKQTIST
N
L
S
I
--
---
GET
K
FTG
G
ITA
H
NS
Q
fig|585056.7.peg.3545
Escherichia coli UMN026 (1-711/1295)
MNKIYSLKYS
AA
TGGL
I
AVSELA
K
RV
SGK
T
N
R
KL
---
-
---
VATMLSLAVAGT---VN---
A
A
N
I
DISNV
W
A
RDY
L
D
L
AQNKG
I
FQ
P
GAT
DV
T
I
TL
K
N
G
DKF
-
S
F
HNL
S
IP
DFS
G
A
A
--
A
----
S
G
A
AT
A
IGG
S
Y
SV
T
V
A
HN
K
KN
PQ
A
AE
TQ
VYA
Q
S
S
Y
RVV
D
R
R
NS-
--
N
DF
EIQ
RL
N
K
F
VVET
V
G
ATPAETNPT
T
YSD
ALERYG
IVTSDGS
K
KIIG
FRAGSG
GT
S
FING-
--
-----
-
-
-
-
---
E
SKISTNSA-YSH
D
L
L
S
-
A
S
LFE
V
TQWDSYG
M
----
MIYK
N
D
-
KT
F
R
N
LEIF
GDSGS
GA
Y
L
YDN
KLE
KWVL
V
G
-
-
T
TH
--
G
IAS-V
N
GDQL
T
WITKY
N
DKLV
S
E
LK
DTYSHKI
N
---
----
-
-
-
-
-
L
N
G
-NNVTIK
N
T
D
I
T
LHQNNADTT
G
TQEK
----
ITKD
-
KD
I
V
F
T
N
G
-
G
D
V
L
F
K
D
N
LDF
G
S
G
G
I
I
F
D
E
GHE
Y
N
I
NGQG
--
-F
TFKGAGID
IGKESI
V
N
WN
AL
Y
SSD
D
V
LHKIG
P
GTL
N
V
QKK
--
Q
GA
N
I
K
I
GEG
N
VIL
NE
E
--
--
-
-
-
G
TFNNI
Y
L
ASG
N
G
K
V
I
LN
KDNS
L
G
-
NDQ
Y
A
GI
F
F
TK
R
GG
T
LDLNG
H
NQTF
T
R
IAATD
D
G
T
T
ITNS
D
TT
K
E
A
V
L
A
I
N
-
------------------------------------------------------------------
----
-
----
-------
N
EDS
YIYHG
N
I
N
GN
I
KLTH
---
NINSQDKKTNAK
LILDG
S
V
N
T
-
K
N
DVEVS
N
AS
L
T
MQGHAT
E
HA
IFRSS-ANHCSLV----
FLCG
T
D
W
V
TVLKET
E
SSYN
K
KFNSDY
K
S
NNQ
Q
T
SF
D
Q
P
DW
K
TG
V
F
K
F
DT
L
H
L
N
N
A
D
F
S
I
S
RNA
N
V
E
G
N
I
S
A
-
NK
S
A
ITIG
--
D
KN
V
YID
NLA
GKNIT
N
N
G
F
D
FKQTIST
N
L
S
I
--
---
GET
K
FTG
G
ITA
H
NS
Q
fig|525281.3.peg.3272
Escherichia coli 83972 (1-711/1295)
MNKIYSLKYS
AA
TGGL
I
AVSELA
K
RV
SGK
T
N
R
KL
---
-
---
VATMLSLAVAGT---VN---
A
A
N
I
DISNV
W
A
RDY
L
D
L
AQNKG
I
FQ
P
GAT
DV
T
I
TL
K
N
G
DKF
-
S
F
HNL
S
IP
DFS
G
A
A
--
A
----
S
G
A
AT
A
IGG
S
Y
SV
T
V
A
HN
K
KN
PQ
A
AE
TQ
VYA
Q
S
S
Y
KVV
D
R
R
NS-
--
N
DF
EIQ
RL
N
K
F
VVET
V
G
ATPAETNPT
T
YSD
ALERYG
IVTSDGS
K
KIIG
FRAGSG
GT
S
FING-
--
-----
-
-
-
-
---
E
SKISTNSA-YSH
D
L
L
S
-
A
S
LFE
V
TQWDSYG
M
----
MIYK
N
D
-
KT
F
R
N
LEIF
GDSGS
GA
Y
L
YDN
KLE
KWVL
V
G
-
-
T
TH
--
G
IAS-V
N
GDQL
T
WITKY
N
DKLV
S
E
LK
DTYSHKI
N
---
----
-
-
-
-
-
L
N
G
-NNVTIK
N
T
D
I
T
LHQNNADTT
G
TQEK
----
ITKD
-
KD
I
V
F
T
N
G
-
G
N
V
L
F
K
D
N
LDF
G
S
G
G
I
I
F
D
E
GHE
Y
N
I
NGQG
--
-F
TFKGAGID
IGKESI
V
N
WN
AL
Y
SSD
D
V
LHKIG
P
GTL
N
V
QKK
--
Q
GA
N
I
K
I
GEG
N
VIL
NE
E
--
--
-
-
-
G
TFNNI
Y
L
ASG
N
G
K
V
I
LN
KDNS
L
G
-
NDQ
Y
A
GI
F
F
TK
R
GG
T
LDLNG
H
NQTF
T
R
IAATD
D
G
T
T
ITNS
D
TT
K
E
A
V
L
A
I
N
-
------------------------------------------------------------------
----
-
----
-------
N
EDS
YIYHG
N
I
N
GN
I
KLTH
---
NINSQDKKTNAK
LILDG
S
V
N
T
-
K
N
DVEVS
N
AS
L
T
MQGHAT
E
HA
IFRST-ANHCSLV----
FLCG
T
D
W
V
TVLKET
E
SSYN
K
KFNSDH
K
S
NNQ
Q
T
SF
D
Q
P
DW
K
TG
V
F
K
F
DT
L
H
L
N
N
A
D
F
S
I
S
RNA
N
V
E
G
N
I
S
A
-
NK
S
A
ITIG
--
D
KN
AYID
NLA
GKNIT
N
N
G
F
D
FKQTIST
N
L
S
I
--
---
GET
K
FTG
G
ITA
H
NS
Q
fig|655817.3.peg.3424
Escherichia coli ABU 83972 (1-711/1295)
MNKIYSLKYS
AA
TGGL
I
AVSELA
K
RV
SGK
T
N
R
KL
---
-
---
VATMLSLAVAGT---VN---
A
A
N
I
DISNV
W
A
RDY
L
D
L
AQNKG
I
FQ
P
GAT
DV
T
I
TL
K
N
G
DKF
-
S
F
HNL
S
IP
DFS
G
A
A
--
A
----
S
G
A
AT
A
IGG
S
Y
SV
T
V
A
HN
K
KN
PQ
A
AE
TQ
VYA
Q
S
S
Y
KVV
D
R
R
NS-
--
N
DF
EIQ
RL
N
K
F
VVET
V
G
ATPAETNPT
T
YSD
ALERYG
IVTSDGS
K
KIIG
FRAGSG
GT
S
FING-
--
-----
-
-
-
-
---
E
SKISTNSA-YSH
D
L
L
S
-
A
S
LFE
V
TQWDSYG
M
----
MIYK
N
D
-
KT
F
R
N
LEIF
GDSGS
GA
Y
L
YDN
KLE
KWVL
V
G
-
-
T
TH
--
G
IAS-V
N
GDQL
T
WITKY
N
DKLV
S
E
LK
DTYSHKI
N
---
----
-
-
-
-
-
L
N
G
-NNVTIK
N
T
D
I
T
LHQNNADTT
G
TQEK
----
ITKD
-
KD
I
V
F
T
N
G
-
G
N
V
L
F
K
D
N
LDF
G
S
G
G
I
I
F
D
E
GHE
Y
N
I
NGQG
--
-F
TFKGAGID
IGKESI
V
N
WN
AL
Y
SSD
D
V
LHKIG
P
GTL
N
V
QKK
--
Q
GA
N
I
K
I
GEG
N
VIL
NE
E
--
--
-
-
-
G
TFNNI
Y
L
ASG
N
G
K
V
I
LN
KDNS
L
G
-
NDQ
Y
A
GI
F
F
TK
R
GG
T
LDLNG
H
NQTF
T
R
IAATD
D
G
T
T
ITNS
D
TT
K
E
A
V
L
A
I
N
-
------------------------------------------------------------------
----
-
----
-------
N
EDS
YIYHG
N
I
N
GN
I
KLTH
---
NINSQDKKTNAK
LILDG
S
V
N
T
-
K
N
DVEVS
N
AS
L
T
MQGHAT
E
HA
IFRST-ANHCSLV----
FLCG
T
D
W
V
TVLKET
E
SSYN
K
KFNSDH
K
S
NNQ
Q
T
SF
D
Q
P
DW
K
TG
V
F
K
F
DT
L
H
L
N
N
A
D
F
S
I
S
RNA
N
V
E
G
N
I
S
A
-
NK
S
A
ITIG
--
D
KN
AYID
NLA
GKNIT
N
N
G
F
D
FKQTIST
N
L
S
I
--
---
GET
K
FTG
G
ITA
H
NS
Q
fig|749527.3.peg.5203
Escherichia coli MS 21-1 (1-711/1295)
MNKIYSLKYS
AA
TGGL
I
AVSELA
K
RV
SGK
T
N
R
KL
---
-
---
VATMLSLAVAGT---VN---
A
A
N
I
DISNV
W
A
RDY
L
D
L
AQNKG
I
FQ
P
GAT
DV
T
I
TL
K
N
G
DKF
-
S
F
HNL
S
IP
DFS
G
A
A
--
A
----
S
G
A
AT
A
IGG
S
Y
SV
T
V
A
HN
K
KN
PQ
A
AE
TQ
VYA
Q
S
S
Y
KVV
D
R
R
NS-
--
N
DF
EIQ
RL
N
K
F
VVET
V
G
ATPAETNPT
T
YSD
ALERYG
IVTSDGS
K
KIIG
FRAGSG
GT
S
FING-
--
-----
-
-
-
-
---
E
SKISTNSA-YSH
D
L
L
S
-
A
S
LFE
V
TQWDSYG
M
----
MIYK
N
D
-
KT
F
R
N
LEIF
GDSGS
GA
Y
L
YDN
KLE
KWVL
V
G
-
-
T
TH
--
G
IAS-V
N
GDQL
T
WITKY
N
DKLV
S
E
LK
DTYSHKI
N
---
----
-
-
-
-
-
L
N
G
-NNVTIK
N
T
D
I
T
LHQNNADTT
G
TQEK
----
ITKD
-
KD
I
V
F
T
N
G
-
G
N
V
L
F
K
D
N
LDF
G
S
G
G
I
I
F
D
E
GHE
Y
N
I
NGQG
--
-F
TFKGAGID
IGKESI
V
N
WN
AL
Y
SSD
D
V
LHKIG
P
GTL
N
V
QKK
--
Q
GA
N
I
K
I
GEG
N
VIL
NE
E
--
--
-
-
-
G
TFNNI
Y
L
ASG
N
G
K
V
I
LN
KDNS
L
G
-
NDQ
Y
A
GI
F
F
TK
R
GG
T
LDLNG
H
NQTF
T
R
IAATD
D
G
T
T
ITNS
D
TT
K
E
A
V
L
A
I
N
-
------------------------------------------------------------------
----
-
----
-------
N
EDS
YIYHG
N
I
N
GN
I
KLTH
---
NINSQDKKTNAK
LILDG
S
V
N
T
-
K
N
DVEVS
N
AS
L
T
MQGHAT
E
HA
IFRST-ANHCSLV----
FLCG
T
D
W
V
TVLKET
E
SSYN
K
KFNSDH
K
S
NNQ
Q
T
SF
D
Q
P
DW
K
TG
V
F
K
F
DT
L
H
L
N
N
A
D
F
S
I
S
RNA
N
V
E
G
N
I
S
A
-
NK
S
A
ITIG
--
D
KN
AYID
NLA
GKNIT
N
N
G
F
D
FKQTIST
N
L
S
I
--
---
GET
K
FTG
G
ITA
H
NS
Q
fig|749528.3.peg.4271
Escherichia coli MS 45-1 (1-711/1295)
MNKIYSLKYS
AA
TGGL
I
AVSELA
K
RV
SGK
T
N
R
KL
---
-
---
VATMLSLAVAGT---VN---
A
A
N
I
DISNV
W
A
RDY
L
D
L
AQNKG
I
FQ
P
GAT
DV
T
I
TL
K
N
G
DKF
-
S
F
HNL
S
IP
DFS
G
A
A
--
A
----
S
G
A
AT
A
IGG
S
Y
SV
T
V
A
HN
K
KN
PQ
A
AE
TQ
VYA
Q
S
S
Y
KVV
D
R
R
NS-
--
N
DF
EIQ
RL
N
K
F
VVET
V
G
ATPAETNPT
T
YSD
ALERYG
IVTSDGS
K
KIIG
FRAGSG
GT
S
FING-
--
-----
-
-
-
-
---
E
SKISTNSA-YSH
D
L
L
S
-
A
S
LFE
V
TQWDSYG
M
----
MIYK
N
D
-
KT
F
R
N
LEIF
GDSGS
GA
Y
L
YDN
KLE
KWVL
V
G
-
-
T
TH
--
G
IAS-V
N
GDQL
T
WITKY
N
DKLV
S
E
LK
DTYSHKI
N
---
----
-
-
-
-
-
L
N
G
-NNVTIK
N
T
D
I
T
LHQNNADTT
G
TQEK
----
ITKD
-
KD
I
V
F
T
N
G
-
G
N
V
L
F
K
D
N
LDF
G
S
G
G
I
I
F
D
E
GHE
Y
N
I
NGQG
--
-F
TFKGAGID
IGKESI
V
N
WN
AL
Y
SSD
D
V
LHKIG
P
GTL
N
V
QKK
--
Q
GA
N
I
K
I
GEG
N
VIL
NE
E
--
--
-
-
-
G
TFNNI
Y
L
ASG
N
G
K
V
I
LN
KDNS
L
G
-
NDQ
Y
A
GI
F
F
TK
R
GG
T
LDLNG
H
NQTF
T
R
IAATD
D
G
T
T
ITNS
D
TT
K
E
A
V
L
A
I
N
-
------------------------------------------------------------------
----
-
----
-------
N
EDS
YIYHG
N
I
N
GN
I
KLTH
---
NINSQDKKTNAK
LILDG
S
V
N
T
-
K
N
DVEVS
N
AS
L
T
MQGHAT
E
HA
IFRST-ANHCSLV----
FLCG
T
D
W
V
TVLKET
E
SSYN
K
KFNSDH
K
S
NNQ
Q
T
SF
D
Q
P
DW
K
TG
V
F
K
F
DT
L
H
L
N
N
A
D
F
S
I
S
RNA
N
V
E
G
N
I
S
A
-
NK
S
A
ITIG
--
D
KN
AYID
NLA
GKNIT
N
N
G
F
D
FKQTIST
N
L
S
I
--
---
GET
K
FTG
G
ITA
H
NS
Q
fig|749531.3.peg.1025
Escherichia coli MS 69-1 (1-711/1295)
MNKIYSLKYS
AA
TGGL
I
AVSELA
K
RV
SGK
T
N
R
KL
---
-
---
VATMLSLAVAGT---VN---
A
A
N
I
DISNV
W
A
RDY
L
D
L
AQNKG
I
FQ
P
GAT
DV
T
I
TL
K
N
G
DKF
-
S
F
HNL
S
IP
DFS
G
A
A
--
A
----
S
G
A
AT
A
IGG
S
Y
SV
T
V
A
HN
K
KN
PQ
A
AE
TQ
VYA
Q
S
S
Y
KVV
D
R
R
NS-
--
N
DF
EIQ
RL
N
K
F
VVET
V
G
ATPAETNPT
T
YSD
ALERYG
IVTSDGS
K
KIIG
FRAGSG
GT
S
FING-
--
-----
-
-
-
-
---
E
SKISTNSA-YSH
D
L
L
S
-
A
S
LFE
V
TQWDSYG
M
----
MIYK
N
D
-
KT
F
R
N
LEIF
GDSGS
GA
Y
L
YDN
KLE
KWVL
V
G
-
-
T
TH
--
G
IAS-V
N
GDQL
T
WITKY
N
DKLV
S
K
LK
DTYSHKI
N
---
----
-
-
-
-
-
L
N
G
-NNVTIK
N
T
D
I
T
LHQNNADTT
G
TQEK
----
ITKD
-
KD
I
V
F
T
N
G
-
G
N
V
L
F
K
D
N
LDF
G
S
G
G
I
I
F
D
E
GHE
Y
N
I
NGQG
--
-F
TFKGAGID
IGKESI
V
N
WN
AL
Y
SSD
D
V
LHKIG
P
GTL
N
V
QKK
--
Q
GA
N
I
K
I
GEG
N
VIL
NE
E
--
--
-
-
-
G
TFNNI
Y
L
ASG
N
G
K
V
I
LN
KDNS
L
G
-
NDQ
Y
A
GI
F
F
TK
R
GG
T
LDLNG
H
NQTF
T
R
IAATD
D
G
T
T
ITNS
D
TT
K
E
A
V
L
A
I
N
-
------------------------------------------------------------------
----
-
----
-------
N
EDS
YIYHG
N
I
N
GN
I
KLTH
---
NINSQDKKTNAK
LILDG
S
V
N
T
-
K
N
DVEVS
N
AS
L
T
MQGHAT
E
HA
IFRST-ANHCSLV----
FLCG
T
D
W
V
TVLKET
E
SSYN
K
KFNSDY
K
S
NNQ
Q
T
SF
D
Q
P
DW
K
TG
V
F
K
F
DT
L
H
L
N
N
A
D
F
S
I
S
RNA
N
V
E
G
N
I
S
A
-
NK
S
A
ITIG
--
D
KN
V
YID
NLA
GKNIT
N
N
G
F
D
FKQTIST
N
L
S
I
--
---
GET
K
FTG
G
ITA
H
NS
Q
fig|749548.3.peg.1831
Escherichia coli MS 196-1 (1-711/1295)
MNKIYSLKYS
AA
TGGL
I
AVSELA
K
RV
SGK
T
N
R
KL
---
-
---
VATMLSLAVAGT---VN---
A
A
N
I
DISNV
W
A
RDY
L
D
L
AQNKG
I
FQ
P
GAT
DV
T
I
TL
K
N
G
DKF
-
S
F
HNL
S
IP
DFS
G
A
A
--
A
----
S
G
A
AT
A
IGG
S
Y
SV
T
V
A
HN
K
KN
PQ
A
AE
TQ
VYA
Q
S
S
Y
KVV
D
R
R
NS-
--
N
DF
EIQ
RL
N
K
F
VVET
V
G
ATPAETNPT
T
YSD
ALERYG
IVTSDGS
K
KIIG
FRAGSG
GT
S
FING-
--
-----
-
-
-
-
---
E
SKISTNSA-YSH
D
L
L
S
-
A
S
LFE
V
TQWDSYG
M
----
MIYK
N
D
-
KT
F
R
N
LEIF
GDSGS
GA
Y
L
YDN
KLE
KWVL
V
G
-
-
T
TH
--
G
IAS-V
N
GDQL
T
WITKY
N
DKLV
S
E
LK
DTYSHKI
N
---
----
-
-
-
-
-
L
N
G
-NNVTIK
N
T
D
I
T
LHQNNADTT
G
TQEK
----
ITKD
-
KD
I
V
F
T
N
G
-
G
N
V
L
F
K
D
N
LDF
G
S
G
G
I
I
F
D
E
GHE
Y
N
I
NGQG
--
-F
TFKGAGID
IGKESI
V
N
WN
AL
Y
SSD
D
V
LHKIG
P
GTL
N
V
QKK
--
Q
GA
N
I
K
I
GEG
N
VIL
NE
E
--
--
-
-
-
G
TFNNI
Y
L
ASG
N
G
K
V
I
LN
KDNS
L
G
-
NDQ
Y
A
GI
F
F
TK
R
GG
T
LDLNG
H
NQTF
T
R
IAATD
D
G
T
T
ITNS
D
TT
K
E
A
V
L
A
I
N
-
------------------------------------------------------------------
----
-
----
-------
N
EDS
YIYHG
N
I
N
GN
I
KLTH
---
NINSQDKKTNAK
LILDG
S
V
N
T
-
K
N
DVEVS
N
AS
L
T
MQGHAT
E
HA
IFRST-ANHCSLV----
FLCG
T
D
W
V
TVLKET
E
SSYN
K
KFNSDH
K
S
NNQ
Q
T
SF
D
Q
P
DW
K
TG
V
F
K
F
DT
L
H
L
N
N
A
D
F
S
I
S
RNA
N
V
E
G
N
I
S
A
-
NK
S
A
ITIG
--
D
KN
AYID
NLA
GKNIT
N
N
G
F
D
FKQTIST
N
L
S
I
--
---
GET
K
FTG
G
ITA
H
NS
Q
fig|585057.4.peg.3549
Escherichia coli IAI39 (1-711/776)
MNKIYSLKYS
AA
TGGL
I
AVSELA
K
RV
SGK
T
N
R
KL
---
-
---
VATMLSLAVAGT---VN---
A
A
N
I
DISNV
W
A
RDY
L
D
L
AQNKG
I
FQ
P
GAT
DV
T
I
TL
K
N
G
DKF
-
S
F
HNL
S
IP
DFS
G
A
A
--
A
----
S
G
A
AT
A
IGG
S
Y
SV
T
V
A
HN
K
KN
PQ
A
AE
TQ
VYA
Q
S
S
Y
KVV
D
R
R
NS-
--
N
DF
EIQ
RL
N
K
F
VVET
V
G
ATPAETNPT
T
YSD
ALERYG
IVTSDGS
K
KIIG
FRAGSG
GT
S
FING-
--
-----
-
-
-
-
---
E
SKISTNSA-YSH
D
L
L
S
-
A
S
LFE
V
TQWDSYG
M
----
MIYK
N
D
-
KT
F
R
N
LEIF
GDSGS
GA
Y
L
YDN
KLE
KWVL
V
G
-
-
T
TH
--
G
IAS-V
N
GDQL
T
WITKY
N
DKLV
S
E
LK
DTYSHKI
N
---
----
-
-
-
-
-
L
N
G
-NNVTIK
N
T
D
I
T
LHQNNADTT
G
TQEK
----
ITKD
-
KD
I
V
F
T
N
G
-
G
N
V
L
F
K
D
N
LDF
G
S
G
G
I
I
F
D
E
GHE
Y
N
I
NGQG
--
-F
TFKGAGID
IGKESI
V
N
WN
AL
Y
SSD
D
V
LHKIG
P
GTL
N
V
QKK
--
Q
GA
N
I
K
I
GEG
N
VIL
NE
E
--
--
-
-
-
G
TFNNI
Y
L
ASG
N
G
K
V
I
LN
KDNS
L
G
-
NDQ
Y
A
GI
F
F
TK
R
GG
T
LDLNG
H
NQTF
T
R
IAATD
D
G
T
T
ITNS
D
TT
K
E
A
V
L
A
I
N
-
------------------------------------------------------------------
----
-
----
-------
N
EDS
YIYHG
N
I
N
GN
I
KLTH
---
NINSQDKKTNAK
LILDG
S
V
N
T
-
K
N
DVEVS
N
AS
L
T
MQGHAT
E
HA
IFRST-ANHCSLV----
FLCG
T
D
W
V
TVLKET
E
SSYN
K
KFNSDH
K
S
NNQ
Q
T
SF
D
Q
P
DW
K
TG
V
F
K
F
DT
L
H
L
N
N
A
D
F
S
I
S
RNA
N
V
E
G
N
I
S
A
-
NK
S
A
ITIG
--
D
KN
AYID
NLA
GKNIT
N
N
G
F
D
FKQTIST
N
L
S
I
--
---
GET
K
FTG
G
ITA
H
NS
Q
fig|585057.6.peg.3558
Escherichia coli IAI39 (1-711/776)
MNKIYSLKYS
AA
TGGL
I
AVSELA
K
RV
SGK
T
N
R
KL
---
-
---
VATMLSLAVAGT---VN---
A
A
N
I
DISNV
W
A
RDY
L
D
L
AQNKG
I
FQ
P
GAT
DV
T
I
TL
K
N
G
DKF
-
S
F
HNL
S
IP
DFS
G
A
A
--
A
----
S
G
A
AT
A
IGG
S
Y
SV
T
V
A
HN
K
KN
PQ
A
AE
TQ
VYA
Q
S
S
Y
KVV
D
R
R
NS-
--
N
DF
EIQ
RL
N
K
F
VVET
V
G
ATPAETNPT
T
YSD
ALERYG
IVTSDGS
K
KIIG
FRAGSG
GT
S
FING-
--
-----
-
-
-
-
---
E
SKISTNSA-YSH
D
L
L
S
-
A
S
LFE
V
TQWDSYG
M
----
MIYK
N
D
-
KT
F
R
N
LEIF
GDSGS
GA
Y
L
YDN
KLE
KWVL
V
G
-
-
T
TH
--
G
IAS-V
N
GDQL
T
WITKY
N
DKLV
S
E
LK
DTYSHKI
N
---
----
-
-
-
-
-
L
N
G
-NNVTIK
N
T
D
I
T
LHQNNADTT
G
TQEK
----
ITKD
-
KD
I
V
F
T
N
G
-
G
N
V
L
F
K
D
N
LDF
G
S
G
G
I
I
F
D
E
GHE
Y
N
I
NGQG
--
-F
TFKGAGID
IGKESI
V
N
WN
AL
Y
SSD
D
V
LHKIG
P
GTL
N
V
QKK
--
Q
GA
N
I
K
I
GEG
N
VIL
NE
E
--
--
-
-
-
G
TFNNI
Y
L
ASG
N
G
K
V
I
LN
KDNS
L
G
-
NDQ
Y
A
GI
F
F
TK
R
GG
T
LDLNG
H
NQTF
T
R
IAATD
D
G
T
T
ITNS
D
TT
K
E
A
V
L
A
I
N
-
------------------------------------------------------------------
----
-
----
-------
N
EDS
YIYHG
N
I
N
GN
I
KLTH
---
NINSQDKKTNAK
LILDG
S
V
N
T
-
K
N
DVEVS
N
AS
L
T
MQGHAT
E
HA
IFRST-ANHCSLV----
FLCG
T
D
W
V
TVLKET
E
SSYN
K
KFNSDH
K
S
NNQ
Q
T
SF
D
Q
P
DW
K
TG
V
F
K
F
DT
L
H
L
N
N
A
D
F
S
I
S
RNA
N
V
E
G
N
I
S
A
-
NK
S
A
ITIG
--
D
KN
AYID
NLA
GKNIT
N
N
G
F
D
FKQTIST
N
L
S
I
--
---
GET
K
FTG
G
ITA
H
NS
Q
fig|550672.3.peg.4213
Escherichia coli B088 (1-702/1281)
MNKIY
V
I
K
K
N
S-
K
G
EA
V
V
VSE
V
S
E
G
I
RKR
V
T
S
RI
---
S
L
--
---SILLVSMFGVLYSAEST
AS
R
A
VYDIP
Y
-
QT
Y
R
DF
S
E
NKG
L
F
K
P
GA
M
D
I
P
L
YD
K
S
G
KVV
A
T
L
DKA
P
MI
DFS
S
N
A
--
R
----
T
G
F
AT
L
AF
P
Q
Y
IV
SV
K
HN
T
G
-
YK
N
VR
FG
YGD
D
T
N
Y
TLV
S
R
N
NYQ
GG
L
DF
HLP
RL
N
K
I
V
T
E
V
I
P
LDITNAGTA
N
GT-
------
--YQNQE
R
FPVF
Y
R
V
G
T
G
TQ
Y
VMNKD
G
N
PVRIA
G
G
Y
A
Y
K
T
G
GIVNP--PFSSN
L
R
F
T
-
T
N
IDN
S
-------
-----
----
-
-
-
-P
L
T
S
WGMA
GDSGS
PL
F
A
W
D
A
QQN
KWV
V
L
A
V
L
H
AA
DRK
VTGRT
N
W--Y
T
IVP--
-
---V
S
Y
V
D
NIMKQDA
D
APV
ISQR
N
K
G
D
-
I
H
W
SYDETTG
I
G
T
LT
QGASSWSMH
G
NPGL
TSPA
SLNS
G
KDL
T
F
Q
G
G
-
G
S
V
V
L
E
NT
VDQ
GAG
T
L
T
F
N
D
D--
Y
S
I
KPLD
--
SQ
T
W
KG
G
GI
I
INGDSI
V
D
W
Q
VN
G
VQG
DNLHK
L
G
T
GTL
K
V
NGT
G
I
N
PG
G
L
N
V
GEG
T
VIL
AQ
RP
D
SN
G
N
V
Q
A
FNN
V
S
I
V
SG
R
P
TV
V
L
S
DAKQ
V
N
P
DN-
-
-
-
V
K
W
GY
R
GG
K
LD
I
NG
N
N
L
TF
H
K
LN
G
A
D
E
GA
V
L
TNS
-
G-
S
L
A
S
VN
L
D
F
------------------------------------------------------------------
NKAD
A
TTAV
AN
-----
-
---
-
I
W
HG
H
F
T
GN
I
DINN
---
---TVTPGTQND
F
V
M
DG
G
VD
T
-
Q
G
SFTQE
N
GR
L
F
I
QGH
PV
I
HA
VSTQAVADKLKTLGDNS
V
L
--
-
-
-
-
------
-
----
-
------
-
-
-
T
Q
P
V
SF
T
Q
D
DWET
R
H
F
S
M
QQ
L
N
L
N
N
A
A
F
D
L
A
RNA
S
L
S
T
N
I
N
A
-
NH
S
T
V
T
L
G
--
S
ED
L
YID
---
----
I
N
DG
N
G
VQTTPSR
G
Q
S
K
AT
TET
D
Q
S
R
F
N
G
R
V
T
L
K
N
fig|656417.3.peg.5218
Escherichia coli M605 (1-703/1283)
MNKIY
V
LK
K
N
H-
R
G
E
I
V
AVSE
V
V
K
N
I
KRK
N
T
S
TF
---
L
L
K
L
KLPTLLLISIMAGGYSFPSC
AS
V
V
SSTTS
Y
-
QT
Y
R
DFA
E
NKG
E
F
RP
GA
E
N
V
P
L
YD
K
N
G
NPV
T
T
L
NKA
P
MI
DFS
S
N
D
--
S
----
T
G
V
AT
L
V
S
P
Q
Y
VV
SV
K
HN
G
G
-
YQ
Y
VK
FG
YAD
D
S
S
Y
ALV
D
R
N
NHW
--
R
DF
HTP
RL
N
K
I
V
T
E
V
T
P
LDITNAGTA
K
GT-
------
--YQNAD
R
FPVF
Y
R
V
G
T
G
TQ
Y
VKDTN
GK
ITYLM
G
A
Y
S
Y
K
T
G
GIVNT--PAISD
W
S
F
V
-
T
N
TTN
T
-------
-----
----
-
-
-
-P
L
S
T
YGTP
GDSGS
PL
F
A
W
D
A
DQN
KWVL
L
A
V
L
N
SY
-
A
G
VNGNT
N
W--Y
T
IIP--
-
---A
G
D
V
K
NTMKQDA
D
APV
NTKQ
G
E
G
D
-
I
H
W
SYDEKTG
L
G
S
LT
QGSTSWEMH
G
NLGA
TWPA
SLNS
G
KDL
T
F
Q
G
G
-
G
T
V
V
L
E
NT
VNQ
GAG
T
L
T
F
D
D
D--
Y
I
V
KPVD
--
TQ
T
W
KG
G
GI
I
VNGEHL
V
D
W
Q
IN
G
VTG
D
S
LHK
L
G
T
GTL
K
I
NGI
GVN
PG
S
L
S
V
G
D
G
T
VIL
AQ
R
AD
DN
G
L
S
Q
A
F
SSV
S
I
V
SG
R
P
T
L
V
LN
DDKQ
I
N
P
DN-
-
-
-
I
K
W
GY
H
GG
K
LD
I
NG
N
S
L
TF
H
K
LN
G
A
D
D
GA
I
L
TNS
-
G-
S
M
A
N
VN
L
D
F
------------------------------------------------------------------
NSPD
T
TATI
AN
-----
-
---
-
I
W
HG
H
F
T
GNL
NINN
---
---EVTAGTQND
FA
I
DG
G
V
N
A
-
Q
G
SITQQ
N
GR
L
F
MQGH
PV
V
HA
VSSQDVANKLKALGDNS
V
L
--
-
-
-
-
------
-
----
-
------
-
-
-
T
Q
P
V
SF
T
Q
N
DWE
NR
Q
F
S
M
AE
L
N
L
Q
N
A
E
F
N
L
A
RNA
S
L
N
T
R
I
N
A
-
DH
S
T
V
T
L
G
--
S
ED
L
YID
---
----
L
N
DG
N
G
VATKPTL
G
K
S
K
AT
AED
D
Q
S
R
F
N
G
H
V
Q
L
Q
fig|340185.3.peg.3806
Escherichia coli E22 (1-710/1290)
MNKI
F
G
V
K
L
N
H-
N
N
K
L
V
V
VSEL
S
C
G
I
KKR
S
R
G
CR
WYD
V
A
K
I
QVLVLLMSGFIAVTSPENVH
AS
D
V
GNILP
Y
-
QT
Y
R
DFAQN
R
G
V
FQ
P
GA
S
NI
T
L
YD
K
N
G
NPA
G
V
L
DKV
P
MM
DFS
S
V
D
--
K
----
L
G
I
AT
L
V
NP
Q
Y
VV
SV
K
HN
G
G
-
YQ
S
VR
Y
G
---
N
Y
TY
TIV
D
R
N
NHW
-
G
L
DF
HAP
RL
N
K
I
V
T
E
V
I
P
SEMTHAGTV
N
NI-
------
--YNDKT
R
FPVF
Y
R
M
GSG
TQ
Y
IKTPS
GK
LQQIA
G
G
Y
S
YLT
G
GTVGSLHSYQKG
E
M
I
S
-
T
S
SGQ
I
YNIA-N-
-----
----
-
-
-
GP
M
A
T
YGEA
GDSGS
PL
F
G
W
D
T
TIN
KW
T
L
V
G
V
L
T
SG
-
N
G
AGGNG
N
N--W
A
VIP--
-
---V
N
Y
V
K
GILAQDS
D
-
P
A
VNNT
S
S
E
K
-
I
L
W
NFDSQTG
T
G
S
LT
QGSQRWDMH
G
SVNG
T
---
NLNN
G
K
N
L
T
F
L
G
S
D
G
Q
M
M
L
N
NA
VDQ
GAG
T
L
T
F
D
A
N--
Y
T
V
SPST
--
NE
T
W
KG
G
GI
I
VNDDHT
V
D
W
Q
VN
G
VKG
DNLHK
L
G
T
GTL
K
V
NGT
GVN
PG
G
L
N
V
GEG
T
VIL
AQ
RP
D
SD
G
N
V
Q
A
FN
I
V
D
I
V
SG
R
P
TV
V
L
S
DDKQ
V
N
P
DN-
-
-
-
I
I
W
DY
R
GG
K
LD
I
NG
N
S
L
TF
H
Q
LN
G
A
D
D
GA
I
L
TNS
-
G-
K
Q
A
T
VN
L
D
F
------------------------------------------------------------------
NKPN
A
TTTV
AN
-----
-
---
-
I
W
HG
H
F
T
GN
V
DVSN
---
---AATTSTQND
F
V
M
DG
G
M
N
I
-
Q
G
SFTQQ
N
GR
L
F
I
QGH
PV
I
HA
ASSQAVANKLKTFGDNS
V
L
--
-
-
-
-
------
-
----
-
------
-
-
-
T
Q
P
V
SF
T
Q
S
DWE
NR
Q
F
S
M
TQ
L
N
L
N
N
A
D
F
S
L
A
RNA
S
L
S
T
L
I
N
A
-
DH
S
T
V
T
L
G
--
S
EN
L
YID
---
----
L
N
DG
N
G
AKTTPSF
G
Q
S
K
AT
NAA
D
Q
S
R
F
S
G
R
V
Q
L
K
N
fig|431946.3.peg.4172
Escherichia coli SE15 (2-698/1278)
LK
K
N
H-
R
G
E
L
V
AVSE
V
V
K
N
I
KRN
S
I
S
TF
---
L
L
K
S
KLSTLLLISIMVGGYSFPSC
AS
V
V
SSTTS
Y
-
QT
Y
R
DFA
E
NKG
E
F
RP
GA
E
DV
P
L
YD
K
N
G
NPV
M
T
L
NKA
P
MI
DFS
S
N
D
--
S
----
T
G
V
AT
L
V
S
P
Q
Y
VV
SV
K
HN
G
G
-
YQ
Y
VK
FG
YAD
D
S
S
Y
ALV
D
R
N
NHW
--
R
DF
HTP
RL
N
K
I
V
T
E
V
T
P
LDITNAGTA
K
GT-
------
--YQNAD
R
FPVF
Y
R
V
G
T
G
TQ
Y
VKDTN
GK
ITYLM
G
A
Y
S
Y
K
T
G
GIVNT--PAISD
W
S
F
V
-
T
N
TTN
T
-------
-----
----
-
-
-
-P
L
S
T
YGTP
GDSGS
PL
F
A
W
D
A
DQN
KWVL
L
A
V
L
N
SY
-
A
G
VNGNT
N
W--Y
T
IIP--
-
---A
G
D
V
K
NTMKQDA
D
APV
NTKQ
G
E
G
D
-
I
H
W
SYDEKTG
L
G
S
LT
QGSTSWEMH
G
NLGA
TWPA
SLNS
G
KDL
T
F
Q
G
G
-
G
T
V
V
L
E
NT
VNQ
GAG
T
L
T
F
D
D
D--
Y
I
V
KPVD
--
TQ
T
W
KG
G
GI
I
VNGEHL
V
D
W
Q
IN
G
VTG
D
S
LHK
L
G
T
GTL
K
I
NGT
GVN
PG
S
L
S
V
G
D
G
T
VIL
AQ
R
AD
DN
G
L
S
Q
A
F
SSV
S
I
V
SG
R
P
T
L
V
LN
DDKQ
I
N
P
DN-
-
-
-
I
K
W
GY
H
GG
K
LD
I
NG
N
S
L
TF
H
K
LN
G
A
D
D
GA
I
L
TNS
-
G-
S
M
A
N
VN
L
D
F
------------------------------------------------------------------
NSPD
T
TATV
AN
-----
-
---
-
I
W
HG
H
F
T
GNL
NINN
---
---EVTAGTQND
FA
I
DG
G
V
N
T
-
Q
G
SITQQ
N
GR
L
F
MQGH
PV
V
HA
VSSQDVANKLKALGDNS
V
L
--
-
-
-
-
------
-
----
-
------
-
-
-
T
Q
P
V
SF
T
Q
N
DWE
NR
Q
F
S
M
AE
L
N
L
Q
N
A
E
F
N
L
A
RNA
S
L
N
T
R
I
N
A
-
EH
S
T
V
T
L
G
--
S
ED
L
YID
---
----
L
N
DG
N
G
VATKPTL
G
K
S
K
AT
AED
D
Q
S
R
F
N
G
H
V
Q
L
Q
fig|550676.3.peg.2951
Escherichia coli B185 (1-771/1299)
MN
R
IYSL
R
YS
AV
A
R
G
F
I
AVSE
F
A
R
K
C
VHK
S
V
R
--
---
-
---
-RLRFPVLLLTPVLFSAGSL
A
G
T
V
NNELE
Y
-
Q
L
F
R
DFA
E
NKG
M
F
RP
GATNI
A
I
YN
K
Q
G
ERG
G
T
L
DKA
A
MP
DFS
A
V
D
--
S
E
---
I
G
V
AT
L
I
NP
Q
Y
IV
SV
K
HN
G
G
-
YT
N
VS
FG
DGE
N
-
R
Y
NIV
D
R
N
NAP
-
S
L
DF
HAP
RLDK
L
V
T
E
V
A
P
TAVTAQGAV
A
GA-
------
--YLDKE
R
YPVF
Y
R
L
GSG
TQ
Y
IKDSN
G
Q
LTQMG
G
A
Y
S
W
LT
G
GTVGSLSSYQNG
E
M
I
S
-
T
S
SGL
V
FDYKLN-
-----
----
-
-
-
GA
M
P
I
YGEA
GDSGS
PL
F
A
F
D
T
VQN
KWVL
V
G
V
L
T
AG
-
N
G
AGGRG
N
N--W
A
VIP--
-
---L
D
F
I
G
QKFNEDN
D
APV
TFRT
S
E
G
G
A
L
E
W
SFNSSTG
A
G
A
LT
QGSTTYAMH
G
QQGN
----
DLNA
G
K
N
L
I
F
Q
G
Q
N
G
Q
I
N
LK
D
S
VSQ
GAG
S
L
T
F
R
D
N--
Y
T
V
TTSN
--
GS
T
WT
GAGI
I
VDNGVS
V
N
W
Q
VN
G
VKG
DNLHKIG
E
GTL
T
V
QGT
G
I
N
EG
G
LK
V
G
D
G
K
V
V
L
NQ
Q
AD
NK
G
Q
V
Q
A
F
SSV
N
IASG
R
P
TV
V
L
T
DERQ
V
N
P
DT-
-
-
-
V
S
W
GY
R
GG
T
LD
V
NG
N
S
L
TF
H
Q
L
K
A
A
D
Y
GA
V
L
A
N
N
-
AD
K
R
A
T
IT
L
D
Y
AL
R
ADK
V
AL
N
G
WS
E
----
S
RK
GT
A
G
N
LY
K
YNNPYT
N
T
T
DYFILK
Q
S
T
YG
Y
FPT
D
Q
S
SN
AT
WE
F
VGH
SQGD
A
QKLV
A
D
R
---
F
N
AAG
Y
L
F
HG
Q
L
K
D
NL
NVDN
---
---RLPEGVTGA
L
V
M
DG
S
A
D
I
-
S
G
TFTQE
N
GR
L
T
L
QGH
PV
I
HA
YNTQSVADKLAASGDHS
V
L
--
-
-
-
-
------
-
----
-
------
-
-
-
T
Q
P
T
SF
S
Q
E
DWE
NR
S
F
T
F
DR
L
S
L
K
N
T
D
F
G
L
G
RNA
T
L
N
T
M
L
E
A
-
TD
S
T
V
T
L
G
--
D
RR
VF
ID
---
----
K
N
DG
N
G
TAFVLEE
G
T
S
E
A
V
KDA
D
R
S
V
F
N
G
S
fig|405955.9.peg.4271
Escherichia coli APEC O1 (1-776/1377)
MN
R
IYSL
R
YS
AV
A
R
G
F
I
AVSE
F
A
R
K
C
VHK
S
V
R
--
---
-
---
-RLCFPVLLLIPVLFSAGSL
A
G
T
V
NNELG
Y
-
Q
L
F
R
DFA
E
NKG
M
F
RP
GATNI
A
I
YN
K
Q
G
EFV
G
T
L
DKA
A
MP
DFS
A
V
D
--
S
E
---
I
G
V
AT
L
I
NP
Q
Y
IA
SV
K
HN
G
G
-
YT
N
VS
FG
DGE
N
-
R
Y
NIV
D
R
N
NAP
-
S
L
DF
HAP
RL
G
K
L
V
T
E
V
A
P
TAVTAQGAV
A
GA-
------
--YLDKE
R
YPVF
Y
R
L
GSG
TQ
Y
IKDSN
G
Q
LTKMG
G
A
Y
S
W
LT
G
GTVGSLSSYQNG
E
M
I
S
-
T
S
SGL
V
FDYKLN-
-----
----
-
-
-
GA
M
P
I
YGEA
GDSGS
PL
F
A
F
D
T
VQN
KWVL
V
G
V
L
T
AG
-
N
G
AGGRG
N
N--W
A
VIP--
-
---L
D
F
I
G
QKFNEDN
D
APV
TFRT
S
E
G
G
A
L
E
W
SFNSSTG
A
G
A
LT
QGTTTYAMH
G
QQGN
----
DLNA
G
K
N
L
I
F
Q
G
Q
N
G
Q
I
N
LK
D
S
VSQ
GAG
S
L
T
F
R
D
N--
Y
T
V
TTSN
--
GS
T
WT
GAGI
V
VDNGVS
V
N
W
Q
VN
G
VKG
DNLHKIG
E
GTL
T
V
QGT
G
I
N
EG
G
LK
V
G
D
G
K
V
V
L
NQ
Q
AD
NK
G
Q
V
Q
A
F
SSV
N
IASG
R
P
TV
V
L
T
DERQ
V
N
P
DT-
-
-
-
V
S
W
GY
R
GG
T
LD
V
NG
N
S
L
TF
H
Q
L
K
A
A
D
Y
GA
V
L
A
N
N
-
VD
K
R
A
T
IT
L
D
Y
AL
R
ADK
V
AL
N
G
WS
E
----
S
GK
GT
A
G
N
LY
K
YNNPYT
N
T
T
DYFILK
Q
S
T
YG
Y
FPT
D
Q
S
SN
AT
WE
F
VGH
SQGD
A
QKLV
A
D
R
---
F
N
TAG
Y
L
F
HG
Q
L
K
GNL
NVDN
---
---RLPEGVTGA
L
V
M
DG
A
A
D
I
-
S
G
TFTQE
N
GR
L
T
L
QGH
PV
I
HA
YNTQSVADKLAASGDHS
V
L
--
-
-
-
-
------
-
----
-
------
-
-
-
T
Q
P
T
SF
S
Q
E
DWE
NR
S
F
T
F
DR
L
S
L
K
N
T
D
F
G
L
G
RNA
T
L
N
T
T
I
Q
A
-
DN
S
S
V
T
L
G
--
D
SR
VF
ID
---
----
K
N
DG
Q
G
TAFTLEE
G
T
S
V
AT
KDA
D
K
S
V
F
N
G
T
V
N
L
D
N
fig|656419.3.peg.1851
Escherichia coli M718 (1-776/1377)
MN
R
IYSL
R
YS
AV
A
R
G
F
I
AVSE
F
A
R
K
C
VHK
S
V
R
--
---
-
---
-RLCFPVLLLIPVLFSAGSL
A
G
T
V
NNELG
Y
-
Q
L
F
R
DFA
E
NKG
M
F
RP
GATNI
A
I
YN
K
Q
G
EFV
G
T
L
DKA
A
MP
DFS
A
V
D
--
S
E
---
I
G
V
AT
L
I
NP
Q
Y
IA
SV
K
HN
G
G
-
YT
N
VS
FG
DGE
N
-
R
Y
NIV
D
R
N
NAP
-
S
L
DF
HAP
RL
G
K
L
V
T
E
V
A
P
TAVTAQGAV
A
GA-
------
--YLDKE
R
YPVF
Y
R
L
GSG
TQ
Y
IKDSN
G
Q
LTKMG
G
A
Y
S
W
LT
G
GTVGSLSSYQNG
E
M
I
S
-
T
S
SGL
V
FDYKLN-
-----
----
-
-
-
GA
M
P
I
YGEA
GDSGS
PL
F
A
F
D
T
VQN
KWVL
V
G
V
L
T
AG
-
N
G
AGGRG
N
N--W
A
VIP--
-
---L
D
F
I
G
QKFNEDN
D
APV
TFRT
S
E
G
G
A
L
E
W
SFNSSTG
A
G
A
LT
QGTTTYAMH
G
QQGN
----
DLNA
G
K
N
L
I
F
Q
G
Q
N
G
Q
I
N
LK
D
S
VSQ
GAG
S
L
T
F
R
D
N--
Y
T
V
TTSN
--
GS
T
WT
GAGI
V
VDNGVS
V
N
W
Q
VN
G
VKG
DNLHKIG
E
GTL
T
V
QGT
G
I
N
EG
G
LK
V
G
D
G
K
V
V
L
NQ
Q
AD
NK
G
Q
V
Q
A
F
SSV
N
IASG
R
P
TV
V
L
T
DERQ
V
N
P
DT-
-
-
-
V
S
W
GY
R
GG
T
LD
V
NG
N
S
L
TF
H
Q
L
K
A
A
D
Y
GA
V
L
A
N
N
-
VD
K
R
A
T
IT
L
D
Y
AL
R
ADK
V
AL
N
G
WS
E
----
S
GK
GT
A
G
N
LY
K
YNNPYT
N
T
T
DYFILK
Q
S
T
YG
Y
FPT
D
Q
S
SN
AT
WE
F
VGH
SQGD
A
QKLV
A
D
R
---
F
N
TAG
Y
L
F
HG
Q
L
K
GNL
NVDN
---
---RLPEGVTGA
L
V
M
DG
A
A
D
I
-
S
G
TFTQE
N
GR
L
T
L
QGH
PV
I
HA
YNTQSVADKLAASGDHS
V
L
--
-
-
-
-
------
-
----
-
------
-
-
-
T
Q
P
T
SF
S
Q
E
DWE
NR
S
F
T
F
DR
L
S
L
K
N
T
D
F
G
L
G
RNA
T
L
N
T
T
I
Q
A
-
DN
S
S
V
T
L
G
--
D
SR
VF
ID
---
----
K
N
DG
Q
G
TAFTLEE
G
T
S
V
AT
KDA
D
K
S
V
F
N
G
T
V
N
L
D
N
fig|656440.3.peg.3872
Escherichia coli TA206 (1-695/1255)
M
V
V
VSEL
S
G
G
I
KKS
A
R
N
KL
---
L
---
KSVVILMSTLATQLYSPLIQ
AS
I
V
GMDIP
Y
-
QT
Y
R
DFA
E
NKG
A
F
SD
GA
L
D
I
P
L
YK
K
D
G
TLY
S
T
L
NKA
P
MI
DFS
A
V
D
--
S
G
---
Q
T
V
AT
L
I
S
P
Q
Y
IV
SV
K
HN
T
G
-
YK
N
VR
FG
YRD
D
S
S
Y
ILV
D
R
N
NSS
--
V
DF
HTP
RL
N
K
I
V
T
E
V
V
P
ADITDAGTA
N
GT-
------
--YQNQD
R
FPIF
Y
R
V
G
T
G
TQ
Y
VKDRN
GK
LTQLA
G
G
Y
A
Y
R
T
G
GTVGK--PTSSN
K
R
I
V
-
S
N
PGN
T
YSAA-N-
-----
----
-
-
-
GP
M
P
S
YGIP
GDSGS
PL
F
A
W
D
T
QRN
KWVL
V
A
V
L
N
SY
-
A
G
NAGKT
N
W--F
T
VIP--
-
---V
N
E
VS
ANIEADT
D
APV
TPTS
T
T
E
N
-
I
N
W
TYDISTG
T
G
K
LT
QGTDAWEMH
G
RDTG
SSAV
SFNH
G
KDL
S
F
E
N
T
-
G
T
V
V
LK
DI
VNQ
GAG
T
I
T
F
N
G
D--
Y
L
V
KPDA
--
DQ
T
W
V
G
G
GI
I
VNGDHT
V
N
W
Q
VN
G
VKG
D
SM
HK
L
G
T
GTL
N
I
SGT
G
I
N
PG
T
L
S
V
G
D
G
T
V
V
L
AQ
K
P
D
SN
G
Q
V
Q
A
F
E
S
A
S
I
V
SG
R
P
T
L
V
L
S
DSQQ
M
N
P
DN-
-
-
-
I
K
W
GY
R
GG
K
LD
I
NG
N
D
L
I
F
H
A
LN
A
A
D
E
GA
I
L
TNS
-
G-
S
L
A
T
A
N
L
D
F
------------------------------------------------------------------
NSTD
T
TKPV
TT
-----
-
---
-
M
F
HG
F
F
T
GN
V
NVKN
---
---NATSNVNNT
F
V
V
DG
G
I
N
T
P
A
G
SMTQQ
G
GR
L
F
F
QGH
PV
I
HA
VSTQSVANKLKALGDDS
V
L
--
-
-
-
-
------
-
----
-
------
-
-
-
T
Q
P
V
SF
T
Q
S
DW
Q
T
R
Q
F
N
L
KS
L
D
L
N
N
A
A
F
Y
L
A
RNA
G
L
T
T
T
I
N
A
-
NN
S
T
V
T
L
G
--
S
ED
L
YID
---
----
T
N
DG
N
G
VKTTPVE
G
Q
S
V
AT
ASE
D
Q
S
H
FTG
N
V
N
L
T
N
fig|199310.1.peg.374
Escherichia coli CFT073 (1-775/1376)
MNKIY
A
LKY
C
YI
T
NTV
K
V
VSELA
R
RV
CKG
S
T
R
RG
---
-
---
KRLSVLTSLALSALLPTVAG
AS
T
V
GGNNP
Y
-
QT
Y
R
DFA
E
NKG
Q
FQAGATNI
P
I
FN
N
K
G
ELV
G
H
L
DKA
P
MV
DFS
S
V
N
VS
S
N
---
P
G
V
AT
L
I
NP
Q
Y
IA
SV
K
HN
K
G
-
YQ
S
VS
FG
DGQ
N
-
S
Y
HIV
D
R
N
EHS
-
S
S
D
L
HTP
RLDK
L
V
T
E
V
A
P
ATVTS--SS
T
AD-
------
--ILNPS
K
YSAF
Y
RAGSG
SQ
Y
IQDSQ
GK
RHWVT
G
G
Y
G
YLT
G
GILPTSFFYHGS
D
G
I
Q
L
Y
M
GGN
I
HDHSI--
-----
----
-
-
-
--
L
P
S
FGEA
GDSGS
PL
F
G
WN
T
AKG
Q
W
E
L
V
G
V
Y
S
--
--
G
VGG-G
T
NLIY
S
LIP--
-
---Q
S
F
L
S
QIYSEDN
D
APV
FFNA
S
S
G
A
P
L
Q
W
KFDSSTG
T
G
S
L
K
QGSDEYAMH
G
QKGS
----
DLNA
G
K
N
L
T
F
L
G
H
N
G
Q
I
D
L
E
N
S
VTQ
GAG
S
L
T
F
T
D
D--
Y
T
V
TTSN
--
GS
T
WT
GAGI
I
VDKDAS
V
N
W
Q
VN
G
VKG
DNLHKIG
E
GTL
V
V
QGT
GVN
EG
G
LK
V
G
D
G
T
V
V
L
NQ
Q
AD
SS
G
H
V
Q
A
F
SSV
N
IASG
R
P
TV
V
L
A
DNQQ
V
N
P
DN-
-
-
-
I
S
W
GY
R
GG
V
LD
V
NG
N
D
L
TF
H
K
LN
A
A
D
Y
GA
T
LG
NS
-
SD
K
T
A
N
IT
L
D
Y
QTRPADVKVNEWSS
----
SNRGTVGSLYIYNNPYTHTVDYFILKTSSYGWFPTGQVSNEHWEYVGH
DQNS
A
QALL
ANR
---
I
N
NKG
Y
L
YHG
K
L
L
GN
I
NFSN
---
---KATPGTTGA
L
V
M
DG
S
AN
M
-
S
G
TFTQE
N
GR
L
T
I
QGH
PV
I
HA
STSQSIANTVSSLGDNS
V
L
--
-
-
-
-
------
-
----
-
------
-
-
-
T
Q
P
T
SF
T
Q
D
DWE
NR
T
F
S
F
GS
L
V
L
K
D
T
D
F
G
L
G
RNA
T
L
N
T
T
I
Q
A
-
DN
S
S
V
T
L
G
--
D
SR
VF
ID
---
----
K
K
DG
Q
G
TAFTLEE
G
T
S
V
AT
KDA
D
K
S
V
F
N
G
T
V
N
L
D
N
fig|749528.3.peg.1421
Escherichia coli MS 45-1 (1-775/1376)
MNKIY
A
LKY
C
YI
T
NTV
K
V
VSELA
R
RV
CKG
S
T
R
RG
---
-
---
KRLSVLTSLALSALLPTVAG
AS
T
V
GGNNP
Y
-
QT
Y
R
DFA
E
NKG
Q
FQAGATNI
P
I
FN
N
K
G
ELV
G
H
L
DKA
P
MV
DFS
S
V
N
VS
S
N
---
P
G
V
AT
L
I
NP
Q
Y
IA
SV
K
HN
K
G
-
YQ
S
VS
FG
DGQ
N
-
S
Y
HIV
D
R
N
EHS
-
S
S
D
L
HTP
RLDK
L
V
T
E
V
A
P
ATVTS--SS
T
AD-
------
--ILNPS
K
YSAF
Y
RAGSG
SQ
Y
IQDSQ
GK
RHWVT
G
G
Y
G
YLT
G
GILPTSFFYHGS
D
G
I
Q
L
Y
M
GGN
I
HDHSI--
-----
----
-
-
-
--
L
P
S
FGEA
GDSGS
PL
F
G
WN
T
AKG
Q
W
E
L
V
G
V
Y
S
--
--
G
VGG-G
T
NLIY
S
LIP--
-
---Q
S
F
L
S
QIYSEDN
D
APV
FFNA
S
S
G
A
P
L
Q
W
KFDSSTG
T
G
S
L
K
QGSDEYAMH
G
QKGS
----
DLNA
G
K
N
L
T
F
L
G
H
N
G
Q
I
D
L
E
N
S
VTQ
GAG
S
L
T
F
T
D
D--
Y
T
V
TTSN
--
GS
T
WT
GAGI
I
VDKDAS
V
N
W
Q
VN
G
VKG
DNLHKIG
E
GTL
V
V
QGT
GVN
EG
G
LK
V
G
D
G
T
V
V
L
NQ
Q
AD
SS
G
H
V
Q
A
F
SSV
N
IASG
R
P
TV
V
L
A
DNQQ
V
N
P
DN-
-
-
-
I
S
W
GY
R
GG
V
LD
V
NG
N
D
L
TF
H
K
LN
A
A
D
Y
GA
T
LG
NS
-
SD
K
T
A
N
IT
L
D
Y
QTRPADVKVNEWSS
----
SNRGTVGSLYIYNNPYTHTVDYFILKTSSYGWFPTGQVSNEHWEYVGH
DQNS
A
QALL
ANR
---
I
N
NKG
Y
L
YHG
K
L
L
GN
I
NFSN
---
---KATPGTTGA
L
V
M
DG
S
AN
M
-
S
G
TFTQE
N
GR
L
T
I
QGH
PV
I
HA
STSQSIANTVSSLGDNS
V
L
--
-
-
-
-
------
-
----
-
------
-
-
-
T
Q
P
T
SF
T
Q
D
DWE
NR
T
F
S
F
GS
L
V
L
K
D
T
D
F
G
L
G
RNA
T
L
N
T
T
I
Q
A
-
DN
S
S
V
T
L
G
--
D
SR
VF
ID
---
----
K
K
DG
Q
G
TAFTLEE
G
T
S
V
AT
KDA
D
K
S
V
F
N
G
T
V
N
L
D
N
fig|753642.3.peg.1353
Escherichia coli NC101 (1-775/1376)
MNKIY
A
LKY
C
YI
T
NTV
K
V
VSELA
R
RV
CKG
S
T
R
RG
---
-
---
KRLSVLTSLALSALLPTVAG
AS
T
V
GGNNP
Y
-
QT
Y
R
DFA
E
NKG
Q
FQAGATNI
P
I
FN
N
K
G
ELV
G
H
L
DKA
P
MV
DFS
S
V
N
VS
S
N
---
P
G
V
AT
L
I
NP
Q
Y
IA
SV
K
HN
K
G
-
YQ
S
VS
FG
DGQ
N
-
S
Y
HIV
D
R
N
EHS
-
S
S
D
L
HTP
RLDK
L
V
T
E
V
A
P
ATVTS--SS
T
AD-
------
--ILNPS
K
YSAF
Y
RAGSG
SQ
Y
IQDSQ
GK
RHWVT
G
G
Y
G
YLT
G
GILPTSFFYHGS
D
G
I
Q
L
Y
M
GGN
I
HDHSI--
-----
----
-
-
-
--
L
P
S
FGEA
GDSGS
PL
F
G
WN
T
AKG
Q
W
E
L
V
G
V
Y
S
--
--
G
VGG-G
T
NLIY
S
LIP--
-
---Q
S
F
L
S
QIYSEDN
D
APV
FFNA
S
S
G
A
P
L
Q
W
KFDSSTG
T
G
S
L
K
QGSDEYAMH
G
QKGS
----
DLNA
G
K
N
L
T
F
L
G
H
N
G
Q
I
D
L
E
N
S
VTQ
GAG
S
L
T
F
T
D
D--
Y
T
V
TTSN
--
GS
T
WT
GAGI
I
VDKDAS
V
N
W
Q
VN
G
VKG
DNLHKIG
E
GTL
V
V
QGT
GVN
EG
G
LK
V
G
D
G
T
V
V
L
NQ
Q
AD
SS
G
H
V
Q
A
F
SSV
N
IASG
R
P
TV
V
L
A
DNQQ
V
N
P
DN-
-
-
-
I
S
W
GY
R
GG
V
LD
V
NG
N
D
L
TF
H
K
LN
A
A
D
Y
GA
T
LG
NS
-
SD
K
T
A
N
IT
L
D
Y
QTRPADVKVNEWSS
----
SNRGTVGSLYIYNNPYTHTVDYFILKTSSYGWFPTGQVSNEHWEYVGH
DQNS
A
QALL
ANR
---
I
N
NKG
Y
L
YHG
K
L
L
GN
I
NFSN
---
---KATPGTTGA
L
V
M
DG
S
AN
M
-
S
G
TFTQE
N
GR
L
T
I
QGH
PV
I
HA
STSQSIANTVSSLGDNS
V
L
--
-
-
-
-
------
-
----
-
------
-
-
-
T
Q
P
T
SF
T
Q
D
DWE
NR
T
F
S
F
GS
L
V
L
K
D
T
D
F
G
L
G
RNA
T
L
N
T
T
I
Q
A
-
DN
S
S
V
T
L
G
--
D
SR
VF
ID
---
----
K
K
DG
Q
G
TAFTLEE
G
T
S
V
AT
KDA
D
K
S
V
F
N
G
T
V
N
L
D
N
fig|869729.3.peg.3412
Escherichia coli UM146 (1-775/1376)
MNKIY
A
LKY
C
YI
T
NTV
K
V
VSELA
R
RV
CKG
S
T
R
RG
---
-
---
KRLSVLTSLALSALLPTVAG
AS
T
V
GGNNP
Y
-
QT
Y
R
DFA
E
NKG
Q
FQAGATNI
P
I
FN
N
K
G
ELV
G
H
L
DKA
P
MV
DFS
S
V
N
VS
S
N
---
P
G
V
AT
L
I
NP
Q
Y
IA
SV
K
HN
K
G
-
YQ
S
VS
FG
DGQ
N
-
S
Y
HIV
D
R
N
EHS
-
S
S
D
L
HTP
RLDK
L
V
T
E
V
A
P
ATVTS--SS
T
AD-
------
--ILNPS
K
YSAF
Y
RAGSG
SQ
Y
IQDSQ
GK
RHWVT
G
G
Y
G
YLT
G
GILPTSFFYHGS
D
G
I
Q
L
Y
M
GGN
I
HDHSI--
-----
----
-
-
-
--
L
P
S
FGEA
GDSGS
PL
F
G
WN
T
AKG
Q
W
E
L
V
G
V
Y
S
--
--
G
VGG-G
T
NLIY
S
LIP--
-
---Q
S
F
L
S
QIYSEDN
D
APV
FFNA
S
S
G
A
P
L
Q
W
KFDSSTG
T
G
S
L
K
QGSDEYAMH
G
QKGS
----
DLNA
G
K
N
L
T
F
L
G
H
N
G
Q
I
D
L
E
N
S
VTQ
GAG
S
L
T
F
T
D
D--
Y
T
V
TTSN
--
GS
T
WT
GAGI
I
VDKDAS
V
N
W
Q
VN
G
VKG
DNLHKIG
E
GTL
V
V
QGT
GVN
EG
G
LK
V
G
D
G
T
V
V
L
NQ
Q
AD
SS
G
H
V
Q
A
F
SSV
N
IASG
R
P
TV
V
L
A
DNQQ
V
N
P
DN-
-
-
-
I
S
W
GY
R
GG
V
LD
V
NG
N
D
L
TF
H
K
LN
A
A
D
Y
GA
T
LG
NS
-
SD
K
T
A
N
IT
L
D
Y
QTRPADVKVNEWSS
----
SNRGTVGSLYIYNNPYTHTVDYFILKTSSYGWFPTGQVSNEHWEYVGH
DQNS
A
QALL
ANR
---
I
N
NKG
Y
L
YHG
K
L
L
GN
I
NFSN
---
---KATPGTTGA
L
V
M
DG
S
AN
M
-
S
G
TFTQE
N
GR
L
T
I
QGH
PV
I
HA
STSQSIANTVSSLGDNS
V
L
--
-
-
-
-
------
-
----
-
------
-
-
-
T
Q
P
T
SF
T
Q
D
DWE
NR
T
F
S
F
GS
L
V
L
K
D
T
D
F
G
L
G
RNA
T
L
N
T
T
I
Q
A
-
DN
S
S
V
T
L
G
--
D
SR
VF
ID
---
----
K
K
DG
Q
G
TAFTLEE
G
T
S
V
AT
KDA
D
K
S
V
F
N
G
T
V
N
L
D
N
fig|405955.9.peg.235
Escherichia coli APEC O1 (1-775/1376)
MNKIY
A
LKY
C
YI
T
NTV
K
V
VSELA
R
RV
CKG
S
T
R
RG
---
-
---
KRLSVLTSLALSALLPTVAG
AS
T
V
GGNNP
Y
-
QT
Y
R
DFA
E
NKG
Q
FQAGATNI
P
I
FN
N
K
G
ELV
G
H
L
DKA
P
MV
DFS
S
V
N
VS
S
N
---
P
G
V
AT
L
I
NP
Q
Y
IA
SV
K
HN
K
G
-
YQ
S
VS
FG
DGQ
N
-
S
Y
HIV
D
R
N
EHS
-
S
S
D
L
HTP
RLDK
L
V
T
E
V
A
P
ATVTS--SS
T
AD-
------
--ILNPS
K
YSAF
Y
RAGSG
SQ
Y
IQDSQ
GK
RHWVT
G
G
Y
G
YLT
G
GILPTSFFYHGS
D
G
I
Q
L
Y
M
GGN
I
HDHSI--
-----
----
-
-
-
--
L
P
S
FGEA
GDSGS
PL
F
G
WN
T
AKG
Q
W
E
L
V
G
V
Y
S
--
--
G
VGG-G
T
NLIY
S
LIP--
-
---Q
S
F
L
S
QIYSEDN
D
APV
FFNA
S
S
G
A
P
L
Q
W
KFDSSTG
T
G
S
L
K
QGSDEYAMH
G
QKGS
----
DLNA
G
K
N
L
T
F
L
G
H
N
G
Q
I
D
L
E
N
S
VTQ
GAG
S
L
T
F
T
D
D--
Y
T
V
TTSN
--
GS
T
WT
GAGI
I
VDKDAS
V
N
W
Q
VN
G
VKG
DNLHKIG
E
GTL
V
V
QGT
GVN
EG
G
LK
V
G
D
G
T
V
V
L
NQ
Q
AD
SS
G
H
V
Q
A
F
SSV
N
IASG
R
P
TV
V
L
A
DNQQ
V
N
P
DN-
-
-
-
I
S
W
GY
R
GG
V
LD
V
NG
N
D
L
TF
H
K
LN
A
A
D
Y
GA
T
LG
NS
-
SD
K
T
A
N
IT
L
D
Y
QTRPA
N
VKVNEWSS
----
SNRGTVGSLYIYNNPYTHTVDYFILKTSSYGWFPTGQVSNEHWEYVGH
DQNS
A
QALL
ANR
---
I
N
NKG
Y
L
YHG
K
L
L
GN
I
NFSN
---
---KATPGTTGA
L
V
M
DG
S
AN
M
-
S
G
TFTQE
N
GR
L
T
I
QGH
PV
I
HA
STSQSIANTVSSLGDNS
V
L
--
-
-
-
-
------
-
----
-
------
-
-
-
T
Q
P
T
SF
T
Q
D
DWE
NR
T
F
S
F
GS
L
V
L
K
D
T
D
F
G
L
G
RNA
T
L
N
T
T
I
Q
A
-
DN
S
S
V
T
L
G
--
D
SR
VF
ID
---
----
K
K
DG
Q
G
TAFTLEE
G
T
S
V
AT
KDA
D
K
S
V
F
N
G
T
V
N
L
D
N
fig|340197.3.peg.1397
Escherichia coli F11 (1-775/1376)
MNKIY
A
LKY
C
YI
T
NTV
K
V
VSELA
R
RV
CKG
S
T
R
RG
---
-
---
KRLSVLTSLALSALLPTVAG
AS
T
V
GGNNP
Y
-
QT
Y
R
DFA
E
NKG
Q
FQAGATNI
P
I
FN
N
K
G
ELV
G
H
L
DKA
P
MV
DFS
S
V
N
VS
S
N
---
P
G
V
AT
L
I
NP
Q
Y
IA
SV
K
HN
K
G
-
YQ
S
VS
FG
DGQ
N
-
S
Y
HIV
D
R
N
EHS
-
S
S
D
L
HTP
RLDK
L
V
T
E
V
A
P
ATVTS--SS
T
AD-
------
--ILNPS
K
YSAF
Y
RAGSG
SQ
Y
IQDSQ
GK
RHWVT
G
G
Y
G
YLT
G
GILPTSFFYHGS
D
G
I
Q
L
Y
M
GGN
I
HDHSI--
-----
----
-
-
-
--
L
P
S
FGEA
GDSGS
PL
F
G
WN
T
AKG
Q
W
E
L
V
G
V
Y
S
--
--
G
VGG-G
T
NLIY
S
LIP--
-
---Q
S
F
L
S
QIYSEDN
D
APV
FFNA
S
S
G
A
P
L
Q
W
KFDSSTG
T
G
S
L
K
QGSDEYAMH
G
QKGS
----
DLNA
G
K
N
L
T
F
L
G
H
N
G
Q
I
D
L
E
N
S
VTQ
GAG
S
L
T
F
T
D
D--
Y
T
V
TTSN
--
GS
T
WT
GAGI
I
VDKDAS
V
N
W
Q
VN
G
VKG
DNLHKIG
E
GTL
V
V
QGT
GVN
EG
G
LK
V
G
D
G
T
V
V
L
NQ
Q
AD
SS
G
H
V
Q
A
F
SSV
N
IASG
R
P
TV
V
L
A
DNQQ
V
N
P
DN-
-
-
-
I
S
W
GY
R
GG
V
LD
V
NG
N
D
L
TF
H
K
LN
A
A
D
Y
GA
T
LG
NS
-
SD
K
T
A
N
IT
L
D
Y
QT
H
PADVKVNEWSS
----
SNRGTVGSLYIYNNPYTHTVDYFILKTSSYGWFPTGQVSNEHWEYVGH
DQNS
A
QALL
ANR
---
I
N
NKG
Y
L
YHG
K
L
L
GN
I
NFSN
---
---KATPGTTGA
L
V
M
DG
S
AN
M
-
S
G
TFTQE
N
GR
L
T
I
QGH
PV
I
HA
STSQSIANTVSSLGDNS
V
L
--
-
-
-
-
------
-
----
-
------
-
-
-
T
Q
P
T
SF
T
Q
D
DWE
NR
T
F
S
F
GS
L
V
L
K
D
T
D
F
G
L
G
RNA
T
L
N
T
T
I
Q
A
-
DN
S
S
V
T
L
G
--
D
SR
VF
ID
---
----
K
K
DG
Q
G
TAFTLEE
G
T
S
V
AT
KDA
D
K
S
V
F
N
G
T
V
N
L
D
N
fig|656440.3.peg.153
Escherichia coli TA206 (1-775/1376)
MNKIY
A
LKY
C
YI
T
NTV
K
V
VSELA
R
RV
CKG
S
T
R
RG
---
-
---
KRLSVLTSLALSALLPTVAG
AS
T
V
GGNNP
Y
-
QT
Y
R
DFA
E
NKG
Q
FQAGATNI
P
I
FN
N
K
G
ELV
G
H
L
DKA
P
MV
DFS
S
V
N
VS
S
N
---
P
G
V
AT
L
I
NP
Q
Y
IA
SV
K
HN
K
G
-
YQ
S
VS
FG
DGQ
N
-
S
Y
HIV
D
R
N
EHS
-
S
S
D
L
HTP
RLDK
L
V
T
E
V
A
P
ATVTS--SS
T
AD-
------
--ILNPS
K
YSAF
Y
RAGSG
SQ
Y
IQDSQ
GK
RHWVT
G
G
Y
G
YLT
G
GILPTSFFYHGS
D
G
I
Q
L
Y
M
GGN
I
HDHSI--
-----
----
-
-
-
--
L
P
S
FGEA
GDSGS
PL
F
G
WN
T
AKG
Q
W
E
L
V
G
V
Y
S
--
--
G
VGG-G
T
NLIY
S
LIP--
-
---Q
S
F
L
S
QIYSEDN
D
APV
FFNA
S
S
G
A
P
L
Q
W
KFDSSTG
T
G
S
L
K
QGSDEYAMH
G
QKGS
----
DLNA
G
K
N
L
T
F
L
G
H
N
G
Q
I
D
L
E
N
S
VTQ
GAG
S
L
T
F
T
D
D--
Y
T
V
TTSN
--
GS
T
WT
GAGI
I
VDKDAS
V
N
W
Q
VN
G
VKG
DNLHKIG
E
GTL
V
V
QGT
GVN
EG
G
LK
V
G
D
G
T
V
V
L
NQ
Q
AD
SS
G
H
V
Q
A
F
SSV
N
IASG
R
P
TV
V
L
A
DNQQ
V
N
P
DN-
-
-
-
I
S
W
GY
R
GG
V
LD
V
NG
N
D
L
TF
H
K
LN
A
A
D
Y
GA
T
LG
NS
-
SD
K
T
A
N
IT
L
D
Y
QT
H
PADVKVNEWSS
----
SNRGTVGSLYIYNNPYTHTVDYFILKTSSYGWFPTGQVSNEHWEYVGH
DQNS
A
QALL
ANR
---
I
N
NKG
Y
L
YHG
K
L
L
GN
I
NFSN
---
---KATPGTTGA
L
V
M
DG
S
AN
M
-
S
G
TFTQE
N
GR
L
T
I
QGH
PV
I
HA
STSQSIANTVSSLGDNS
V
L
--
-
-
-
-
------
-
----
-
------
-
-
-
T
Q
P
T
SF
T
Q
D
DWE
NR
T
F
S
F
GS
L
V
L
K
D
T
D
F
G
L
G
RNA
T
L
N
T
T
I
Q
A
-
DN
S
S
V
T
L
G
--
D
SR
VF
ID
---
----
K
K
DG
Q
G
TAFTLEE
G
T
S
V
AT
KDA
D
K
S
V
F
N
G
T
V
N
L
D
N
fig|340184.3.peg.4473
Escherichia coli B7A (1-771/1366)
MNKIY
C
LKY
C
HI
T
KS
L
I
AVSELA
R
R
G
RGT
C
K
S
HH
---
R
LT
R
RVTFSSVAVILSLSSTAQTL
A
A
T
V
SAEIP
Y
-
QT
F
R
DFA
E
NKG
L
F
T
P
GATNI
A
I
YD
K
Q
G
NQV
D
E
L
GKA
P
MA
DFS
S
A
T
ITTGSLP
P
G
D
H
T
L
YS
P
Q
Y
VV
TA
K
H
V
S
G
-
SD
T
MS
FG
YAR
N
-
TY
TAV
G
T
N
NNA
-
G
L
D
I
KTR
RL
S
K
L
V
T
E
V
A
P
AEVSDVGAL
S
GA-
------
--YQAGG
R
FTAF
Y
R
L
G
G
G
MQ
Y
IKDKN
G
N
LTQVY
T
N
G
G
F
L
V
G
GTVGALNSYHNG
Q
M
I
T
-
A
Q
TSD
I
FNPA-N-
-----
----
-
-
-
GP
L
A
N
YLNM
GDSGS
PL
F
A
YD
S
WDE
KWVL
I
G
V
L
S
SG
--
-
-SDYG
N
N--W
V
VTT--
-
---Q
T
F
L
S
QQPQNDF
D
KTI
TYSA
G
A
G
A
-
L
Q
W
KYDAVNG
T
G
S
LT
QGNTIWDMH
G
KKGN
----
DLNA
G
K
N
L
L
L
T
G
N
N
G
E
V
V
L
Q
D
S
VNQ
GAG
Y
L
Q
F
A
N
D--
Y
K
V
SALN
--
GQ
T
W
M
G
G
G
VI
TDKGTH
V
L
W
Q
VN
G
VAG
DNLHK
L
G
E
GTL
M
V
NGT
GVN
AG
G
LK
V
G
D
G
T
VIL
NQ
Q
L
D
TD
G
K
V
Q
A
F
SSV
D
I
S
SG
R
P
TV
V
L
S
DSRQ
V
N
P
DN-
-
-
-
I
S
W
GY
R
GG
R
LDLNG
N
N
L
TF
T
R
I
Q
A
A
D
Y
GA
I
ITN
T
-
SE
K
K
S
T
VT
L
D
L
Q
SLK
A
SDINVPINTINFLGG
RGT
P
G
D
LY
LVES
----
T
GQ
Y
Y
ILK
E
SSY
SP
F
FSDLNNPNI
W
QS
VG
K
DRNK
A
IDTV
KHQKIEA
S
SQP
Y
M
YHG
Q
L
N
GN
M
DVNI
---
---PQLSG-KDV
L
T
LDG
S
V
N
L
P
E
G
SITKK
S
GT
L
I
F
QGH
P
I
I
HA
GTT--------------
--
--
-
-
-
-
------
-
----
-
------
-
-
-
--
-
T
S
A
S
Q
S
DWET
R
Q
F
T
L
GK
L
K
L
D
A
A
T
F
Y
L
S
RN
G
Q
M
H
G
D
I
N
A
V
NG
S
T
V
I
L
G
--
S
DH
VF
T
D
---
----
K
N
DG
T
G
NSVSSVE
G
T
A
T
AT
TTV
D
Q
S
D
Y
R
G
N
L
T
L
E
N
K
S
S
fig|340184.6.peg.4686
Escherichia coli B7A (1-771/1366)
MNKIY
C
LKY
C
HI
T
KS
L
I
AVSELA
R
R
G
RGT
C
K
S
HH
---
R
LT
R
RVTFSSVAVILSLSSTAQTL
A
A
T
V
SAEIP
Y
-
QT
F
R
DFA
E
NKG
L
F
T
P
GATNI
A
I
YD
K
Q
G
NQV
D
E
L
GKA
P
MA
DFS
S
A
T
ITTGSLP
P
G
D
H
T
L
YS
P
Q
Y
VV
TA
K
H
V
S
G
-
SD
T
MS
FG
YAR
N
-
TY
TAV
G
T
N
NNA
-
G
L
D
I
KTR
RL
S
K
L
V
T
E
V
A
P
AEVSDVGAL
S
GA-
------
--YQAGG
R
FTAF
Y
R
L
G
G
G
MQ
Y
IKDKN
G
N
LTQVY
T
N
G
G
F
L
V
G
GTVGALNSYHNG
Q
M
I
T
-
A
Q
TSD
I
FNPA-N-
-----
----
-
-
-
GP
L
A
N
YLNM
GDSGS
PL
F
A
YD
S
WDE
KWVL
I
G
V
L
S
SG
--
-
-SDYG
N
N--W
V
VTT--
-
---Q
T
F
L
S
QQPQNDF
D
KTI
TYSA
G
A
G
A
-
L
Q
W
KYDAVNG
T
G
S
LT
QGNTIWDMH
G
KKGN
----
DLNA
G
K
N
L
L
L
T
G
N
N
G
E
V
V
L
Q
D
S
VNQ
GAG
Y
L
Q
F
A
N
D--
Y
K
V
SALN
--
GQ
T
W
M
G
G
G
VI
TDKGTH
V
L
W
Q
VN
G
VAG
DNLHK
L
G
E
GTL
M
V
NGT
GVN
AG
G
LK
V
G
D
G
T
VIL
NQ
Q
L
D
TD
G
K
V
Q
A
F
SSV
D
I
S
SG
R
P
TV
V
L
S
DSRQ
V
N
P
DN-
-
-
-
I
S
W
GY
R
GG
R
LDLNG
N
N
L
TF
T
R
I
Q
A
A
D
Y
GA
I
ITN
T
-
SE
K
K
S
T
VT
L
D
L
Q
SLK
A
SDINVPINTINFLGG
RGT
P
G
D
LY
LVES
----
T
GQ
Y
Y
ILK
E
SSY
SP
F
FSDLNNPNI
W
QS
VG
K
DRNK
A
IDTV
KHQKIEA
S
SQP
Y
M
YHG
Q
L
N
GN
M
DVNI
---
---PQLSG-KDV
L
T
LDG
S
V
N
L
P
E
G
SITKK
S
GT
L
I
F
QGH
P
I
I
HA
GTT--------------
--
--
-
-
-
-
------
-
----
-
------
-
-
-
--
-
T
S
A
S
Q
S
DWET
R
Q
F
T
L
GK
L
K
L
D
A
A
T
F
Y
L
S
RN
G
Q
M
H
G
D
I
N
A
V
NG
S
T
V
I
L
G
--
S
DH
VF
T
D
---
----
K
N
DG
T
G
NSVSSVE
G
T
A
T
AT
TTV
D
Q
S
D
Y
R
G
N
L
T
L
E
N
K
S
S
Consen1
Primary consensus
MNKIYsLKYs
tggl
aVSELa
rv
a
r
---
---
As
m
y
rdY
DfAqNKG
FqaGATni
i
k
G
-
l
p
DFS
v
--
n
----
G
aT
Igg
Y
ta
HN
kn
s
tq
n
tY
d
n
--
Df
RLdK
VvEt
g
s
aleryg
k
fRaGsG
s
--
-
-
---
g
e
l
-
s
i
-----
n
-
f
n
GDSGS
f
ydn
kWvl
G
-
t
--
G
n
a
n
d
lk
d
---
-
-
-
l
g
ng
lt
-
----
-
Kdl
F
g
-
G
i
lkss
GaG
l
F
d
Y
v
--
TfkGaGid
VeWn
y
DnLHKiG
GTL
V
--
q
nlK
GeG
ViL
e
--
-
-
tFnni
iaSG
gtV
Ln
l
-
y
gI
f
nGG
LDlNGynqtF
kiaAtD
Ga
itNs
-
K
s
lsln
------------------------------------------------------------------
-
-------
n
YiyHG
i
GNl
---
LilDG
vd
-
n
N
L
mQGHat
HA
fLcg
d
v
e
k
k
nnq
ssf
Q
DWetg
F
f
L
L
ns
F
v
RNA
v
g
I
A
-
SnitiG
--
d
ayID
gknit
dG
g
g
S
--
get
FtG
ita
nS
S
Consen2
Secondary consensus
a
c
antv
v
s
ki
g
hkr
a
w
qt
l
e
rp
dv
l
n
g
f
s
a
vs
n
t
np
sv
g
-
fg
q
n
r
s
l
n
t
v
p
------
r
y
v
a
y
gk
g
y
ylte
i
l
m
m
-
f
l
s
y
wn
q
ev
v
s
n
t
-
vs
napv
s
g
p
w
t
ik
g
g
ni
n
n
v
fe
s
i
i
wt
g
vi
q
g
v
l
gvn
gi
d
v
ad
g
v
a
ssv
pk
v
p
-
-
w
r
v
ls
rln
a
t
lg
td
a
id
qtrpadvkvnewss
snrgtvgslyiynnpythtvdyfilktssygwfptgqvsnehweyvgh
a
anr
i
-
f
v
an
g
pv
v
--
-
-
-
-
-
-
ta
dl
knr
m
d
l
t
v
l
s
vf
----
k
n
d
n
at
d
s
n
v
l
d
Consensus 1
(when a gap)
Conservative difference
Consensus 2
(when a gap)
Nonconservative diff.
Other character