┌─ Escherichia coli (20-305/311) K12 (10)  
                                                            ┌┴─ Escherichia coli (20-305/311) 101-1 (7)  
                                                           ┌┴─ Escherichia coli (20-305/311) HS (1)  
                                                          ┌┴─ Escherichia coli (20-305/311) 53638 (3)  
                                                         ┌┴─ Escherichia coli (20-305/315) TA143   
                                                        ┌┴┬─ Escherichia coli (20-305/314) 536 (7)  
                                                        │ └┬─ Escherichia coli (20-305/315) IAI39 (1)  
                                                       ┌┤  └─ Escherichia coli (20-305/311) MS 21-1 (1)  
                                                       ││┌─ Escherichia coli (20-305/314) IAI39 (1)  
                                                       │└┤  ┌─ Escherichia coli (20-305/311) APEC O1 (7)  
                                                       │ │ ┌┴─ Escherichia coli (20-305/315) M605   
┌──────────────────────────────────────────────────────┤ └┬┴─ Escherichia coli (20-305/311) SE15   
│                                                      │  └┬─ Escherichia coli (20-305/315) 83972 (3)  
│                                                      │   └┬─ Escherichia coli (20-305/311) ED1a (2)  
│                                                      │    └─ Escherichia coli (22-307/317) CFT073 (2)  
│                                                      └─ Escherichia coli (20-305/315) B185   
│                                                        ┌─ Escherichia coli MS 69-1   
│                                                       ┌┴─ Escherichia coli TA143   
│                                                      ┌┴─ Escherichia coli B354 (1)  
│                                                     ┌┴─ Escherichia coli (1-303/335) B171   
│                                                    ┌┴─ Escherichia coli MS 145-7   
│                                                   ┌┴┬─ Escherichia coli MS 21-1   
│                                                  ┌┤ └─ Escherichia coli H736   
│                                                  │└┬─ Escherichia coli (16-315/318) 536 (10)  
│                                                 ┌┤ └┬─ Escherichia coli (1-300/303) MS 45-1   
│                                                 ││  └─ Escherichia coli (27-326/329) E2348/69 (1)  
│                                                ┌┤└─ Escherichia coli SMS-3-5   
│                                               ┌┤└─ fig|1040638.4.peg.739 O104:H4 str. LB226692 (27)  
│                                              ┌┤└─ Escherichia coli M605   
│                                             ┌┤└─ Escherichia coli MS 107-1   
│                                             │└┬─ Escherichia coli K12 (36)  
┤                                      ┌──────┤ └─ Escherichia coli MS 196-1   
│     ┌────────────────────────────────┤      └─ Escherichia coli O111:H- str. 11128   
│     │                                └─────────────┬──── fig|6666666.5357.peg.2018 TY-2482 (1-293/312) strain (2)  
│     │                                              └────┬─ Escherichia coli (1-292/299) MS 69-1 (1)  
│     │                                                   └─ Escherichia coli (1-292/299) M718 (2)  
│┌────┤                                                           ┌─ Escherichia coli (8-288/298) FVEC1302 (4)  
││    │                                                          ┌┴─ Escherichia coli (8-288/298) B354   
││    │                                                         ┌┴─ Escherichia coli (8-288/298) MS 21-1   
││    └───────────────────┬─────────────────────────────────────┴─ Escherichia coli (8-288/298) B185   
││                        └────────────────────────────────────────┬─ Escherichia coli (2-286/317) K12 (56)  
││                                                                 └┬─ Escherichia coli (2-286/317) M718   
││                                                                  └┬─ Escherichia coli (2-286/317) 042 (51)  
││                                                                   └┬─ Escherichia coli (2-286/317) 83972 (12)  
││                                                                    └┬─ Escherichia coli (2-286/317) B354   
││                                                                     └─ Escherichia coli (2-286/317) FVEC1302 (3)  
││                                                                    ┌─ Escherichia coli (34-321/324) CFT073 (6)  
││                                                                   ┌┴─ Escherichia coli (29-316/319) SE15 (16)  
││                                                                  ┌┴─ Escherichia coli (34-321/324) 042 (2)  
││                                                                 ┌┴─ Escherichia coli (6-293/296) B354   
││                                                                ┌┴─ Escherichia coli (6-293/296) SMS-3-5   
││                                                               ┌┴─ Escherichia coli (6-293/296) MS 21-1   
└┤                                                              ┌┴─ Escherichia coli (6-293/296) IAI1 (2)  
 │                                                             ┌┴┬─ Escherichia coli (6-293/297) K12 (28)  
 │                                                             │ └┬─ Escherichia coli (6-293/296) TA280   
 │                                                            ┌┤  └─ Escherichia coli (29-321/325) 53638 (2)  
 │                                                           ┌┤└─ Escherichia coli (29-316/319) UMN026 (3)  
 │                                                           │└┬─ Escherichia coli (6-293/297) H299   
 │                                                          ┌┤ └┬─ Escherichia coli (6-293/297) B185   
 │                                                          ││  └─ Escherichia coli (34-321/325) B171 (39)  
 │                                                         ┌┤└─ Escherichia coli (34-321/324) APEC O1 (6)  
 │                                                        ┌┤└─ Escherichia coli (34-321/325) B7A (11)  
 │          ┌─────────────────────────────────────────────┤└─ Escherichia coli (6-293/297) O111:H- str. 11128   
 │          │                                             └─ fig|6666666.5357.peg.1115 TY-2482 (34-321/325) strain   
 │          │                                          ┌─ Escherichia coli (11-293/317) SE15   
 │          │                                         ┌┴─ Escherichia coli (4-286/310) M605   
 │          │                                        ┌┴─ Escherichia coli (32-314/338) 53638 (1)  
 │          │                                       ┌┴─ Escherichia coli (4-286/310) B354   
 │          │                                      ┌┴┬─ Escherichia coli (11-293/317) MS 21-1   
 └──────────┤                                     ┌┤ └─ fig|6666666.5357.peg.2190 TY-2482 (11-293/317) strain (94)  
            │                                     │└┬─ Escherichia coli (11-293/317) SMS-3-5   
            │                                    ┌┤ └┬─ Escherichia coli (4-286/310) K12 (7)  
            │                                    ││  └─ Escherichia coli (11-293/317) MS 115-1   
            │                                   ┌┤└┬─ Escherichia coli (11-293/317) MS 187-1   
            │                                   ││ └─ Escherichia coli (11-293/317) IAI1 (1)  
            │     ┌─────────────────────────────┤└─ Escherichia coli (11-293/317) B185 (1)  
            └─────┤                             └─ Escherichia coli (32-314/338) B171 (4)  
                  │                             ┌─ Escherichia coli (2-291/308) TA280   
                  └─────────────────────────────┤┌─ Escherichia coli (2-290/308) H299   
                                                └┤┌─ Escherichia coli (2-290/308) MS 21-1   
                                                 └┤┌─ Escherichia coli (2-290/308) 042 (6)  
                                                  ││ ┌─ Escherichia coli (2-291/308) 83972 (7)  
                                                  └┤┌┴─ Escherichia coli (2-290/308) MS 69-1   
                                                   ││   ┌─ Escherichia coli (2-291/308) 1125A (16)  
                                                   └┤  ┌┴─ Escherichia coli (2-291/308) O157:H7 EDL933   
                                                    │ ┌┴─ Escherichia coli (2-291/308) O157:H7 str. EC4486   
                                                    │┌┴─ Escherichia coli (2-291/308) B185 (1)  
                                                    └┤┌─ Escherichia coli (2-291/308) B7A (1)  
                                                     └┤┌─ Escherichia coli (2-291/308) MS 116-1 (1)  
                                                      └┤ ┌─ Escherichia coli (2-291/308) K12 (50)  
                                                       └┬┴─ Escherichia coli (2-291/308) 2362-75 (2)  
                                                        └┬─ Escherichia coli (2-291/308) B354   
                                                         └┬─ Escherichia coli (2-291/308) APEC O1 (8)  
                                                          └┬─ Escherichia coli (2-291/308) MS 145-7   
                                                           └─ Escherichia coli (2-291/308) 101-1 (12)  
  
Putative transcriptional regulator LYSR-type (18)
LysR family transcriptional regulator YfeR (18)
HTH-type transcriptional regulator IlvY (17)
D-serine dehydratase transcriptional activator (16)
LysR family transcriptional regulator YbhD (12)
Transcriptional activator MetR (6)
hypothetical protein (4)
Others (4)