fig|1040638.4.peg.689
Escherichia coli O104:H4 str. LB226692
MSRKTQRYSKEFKAEAV
RT
VLENQ
L
SISEGA
S
RLSL
P
EGTLG
Q
WVTAA
R
K
G
LG
TP
G
SR
TV
---
-
---
-
-
-
-
-
AE
---
LE
S
EI
LQ
LRK
A
LNE
A
RLERDILN
C
T
-
--
-
-
----
-
----
-
G
V
A
EK
YA
L
I
EQWRQQFPI
E
AMC
Q
V
F
GVSRSGYYNWVQHEPSDRKQSDERLKL
E
IKVA
H
IRT
RE
T
---
-
---
-
-
YGTRRLQT
E
L
AE
NG
II
VGRDRLARLRKEL
R
L
R
C
K
Q
K
RKFRATTN
S
NHNLPVA
P
NLLNQTF
A
P
T
APNQVWVADLTYVA
T
Q
E
GWLYLAGI
K
DVYTC
E
IV
A
TPWESA
fig|216592.1.peg.2755
Escherichia coli 042 (1-249/379)
MSRKTQRYSKEFKAEAV
RT
VLENQ
L
SISEGA
S
RLSL
P
EGTLG
Q
WVTAA
R
K
G
LG
TP
G
SR
TV
---
-
---
-
-
-
-
-
AE
---
LE
S
EI
LQ
LRK
A
LNE
A
RLERDILN
C
T
-
--
-
-
----
-
----
-
G
V
A
EK
YA
L
I
EQWRQQFPI
E
AMC
Q
V
F
GVSRSGYYNWVQHEPSDRKQSDERLKL
E
IKVA
H
IRT
RE
T
---
-
---
-
-
YGTRRLQT
E
L
AE
NG
II
VGRDRLARLRKEL
R
L
R
C
K
Q
K
RKFRATTN
S
NHNLPVA
P
NLLNQTF
A
P
T
APNQVWVADLTYVA
T
Q
E
GWLYLAGI
K
DVYTC
E
IVG
fig|216592.3.peg.4962
Escherichia coli 042 (1-249/379)
MSRKTQRYSKEFKAEAV
RT
VLENQ
L
SISEGA
S
RLSL
P
EGTLG
Q
WVTAA
R
K
G
LG
TP
G
SR
TV
---
-
---
-
-
-
-
-
AE
---
LE
S
EI
LQ
LRK
A
LNE
A
RLERDILN
C
T
-
--
-
-
----
-
----
-
G
V
A
EK
YA
L
I
EQWRQQFPI
E
AMC
Q
V
F
GVSRSGYYNWVQHEPSDRKQSDERLKL
E
IKVA
H
IRT
RE
T
---
-
---
-
-
YGTRRLQT
E
L
AE
NG
II
VGRDRLARLRKEL
R
L
R
C
K
Q
K
RKFRATTN
S
NHNLPVA
P
NLLNQTF
A
P
T
APNQVWVADLTYVA
T
Q
E
GWLYLAGI
K
DVYTC
E
IVG
fig|358709.5.peg.2371
Escherichia coli 101-1 (1-249/379)
MSRKTQRYSKEFKAEAV
RT
VLENQ
L
SISEGA
S
RLSL
P
EGTLG
Q
WVTAA
R
K
G
LG
TP
G
SR
TV
---
-
---
-
-
-
-
-
AE
---
LE
S
EI
LQ
LRK
A
LNE
A
RLERDILN
C
T
-
--
-
-
----
-
----
-
G
V
A
EK
YA
L
I
EQWRQQFPI
E
AMC
Q
V
F
GVSRSGYYNWVQHEPSDRKQSDERLKL
E
IKVA
H
IRT
RE
T
---
-
---
-
-
YGTRRLQT
E
L
AE
NG
II
VGRDRLARLRKEL
R
L
R
C
K
Q
K
RKFRATTN
S
NHNLPVA
P
NLLNQTF
A
P
T
APNQVWVADLTYVA
T
Q
E
GWLYLAGI
K
DVYTC
E
IVG
fig|585055.6.peg.4951
Escherichia coli 55989 (1-249/379)
MSRKTQRYSKEFKAEAV
RT
VLENQ
L
SISEGA
S
RLSL
P
EGTLG
Q
WVTAA
R
K
G
LG
TP
G
SR
TV
---
-
---
-
-
-
-
-
AE
---
LE
S
EI
LQ
LRK
A
LNE
A
RLERDILN
C
T
-
--
-
-
----
-
----
-
G
V
A
EK
YA
L
I
EQWRQQFPI
E
AMC
Q
V
F
GVSRSGYYNWVQHEPSDRKQSDERLKL
E
IKVA
H
IRT
RE
T
---
-
---
-
-
YGTRRLQT
E
L
AE
NG
II
VGRDRLARLRKEL
R
L
R
C
K
Q
K
RKFRATTN
S
NHNLPVA
P
NLLNQTF
A
P
T
APNQVWVADLTYVA
T
Q
E
GWLYLAGI
K
DVYTC
E
IVG
fig|585055.8.peg.4957
Escherichia coli 55989 (1-249/379)
MSRKTQRYSKEFKAEAV
RT
VLENQ
L
SISEGA
S
RLSL
P
EGTLG
Q
WVTAA
R
K
G
LG
TP
G
SR
TV
---
-
---
-
-
-
-
-
AE
---
LE
S
EI
LQ
LRK
A
LNE
A
RLERDILN
C
T
-
--
-
-
----
-
----
-
G
V
A
EK
YA
L
I
EQWRQQFPI
E
AMC
Q
V
F
GVSRSGYYNWVQHEPSDRKQSDERLKL
E
IKVA
H
IRT
RE
T
---
-
---
-
-
YGTRRLQT
E
L
AE
NG
II
VGRDRLARLRKEL
R
L
R
C
K
Q
K
RKFRATTN
S
NHNLPVA
P
NLLNQTF
A
P
T
APNQVWVADLTYVA
T
Q
E
GWLYLAGI
K
DVYTC
E
IVG
fig|331111.12.peg.5050
Escherichia coli E24377A (1-249/379)
MSRKTQRYSKEFKAEAV
RT
VLENQ
L
SISEGA
S
RLSL
P
EGTLG
Q
WVTAA
R
K
G
LG
TP
G
SR
TV
---
-
---
-
-
-
-
-
AE
---
LE
S
EI
LQ
LRK
A
LNE
A
RLERDILN
C
T
-
--
-
-
----
-
----
-
G
V
A
EK
YA
L
I
EQWRQQFPI
E
AMC
Q
V
F
GVSRSGYYNWVQHEPSDRKQSDERLKL
E
IKVA
H
IRT
RE
T
---
-
---
-
-
YGTRRLQT
E
L
AE
NG
II
VGRDRLARLRKEL
R
L
R
C
K
Q
K
RKFRATTN
S
NHNLPVA
P
NLLNQTF
A
P
T
APNQVWVADLTYVA
T
Q
E
GWLYLAGI
K
DVYTC
E
IVG
fig|749544.3.peg.618
Escherichia coli MS 175-1 (1-249/379)
MSRKTQRYSKEFKAEAV
RT
VLENQ
L
SISEGA
S
RLSL
P
EGTLG
Q
WVTAA
R
K
G
LG
TP
G
SR
TV
---
-
---
-
-
-
-
-
AE
---
LE
S
EI
LQ
LRK
A
LNE
A
RLERDILN
C
T
-
--
-
-
----
-
----
-
G
V
A
EK
YA
L
I
EQWRQQFPI
E
AMC
Q
V
F
GVSRSGYYNWVQHEPSDRKQSDERLKL
E
IKVA
H
IRT
RE
T
---
-
---
-
-
YGTRRLQT
E
L
AE
NG
II
VGRDRLARLRKEL
R
L
R
C
K
Q
K
RKFRATTN
S
NHNLPVA
P
NLLNQTF
A
P
T
APNQVWVADLTYVA
T
Q
E
GWLYLAGI
K
DVYTC
E
IVG
fig|344601.5.peg.905
Escherichia coli B171 (1-249/379)
MSRKTQRYSKEFKAEAV
RT
VLENQ
L
SISEGA
S
RLSL
P
EGTLG
Q
WVTAA
R
K
G
LG
TP
G
SR
TV
---
-
---
-
-
-
-
-
AE
---
LE
S
EI
LQ
LRK
A
LNE
A
RLERDILN
C
T
-
--
-
-
----
-
----
-
G
V
A
EK
YA
L
I
EQWRQQFPI
E
AMC
Q
V
F
GVS
K
SGYYNWVQHEPSDRKQSDERLKL
E
IKVA
H
IRT
RE
T
---
-
---
-
-
YGTRRLQT
E
L
AE
NG
II
VGRDRLARLRKEL
R
L
R
C
K
Q
K
RKFRATTN
S
NHNLPVA
P
NLLNQTF
A
P
T
APNQVWVADLTYVA
T
Q
E
GWLYLAGI
K
DVYTC
E
IVG
fig|550676.3.peg.3031
Escherichia coli B185 (118-381/510)
FE
S
E
V
K
RQ
AV
MA
LCTR
Q
V
S
A
SE
I
A
R
R
IGV
S
RAV
L
Y
K
W
---
K
D
E
I
I
G
NS
A
YQ
T
MRKH
N
---
E
P
S
L
E
AE
RDA
L
R
E
E
V
AR
L
NQ
E
I
RR
R
QM
E
L
DIL
K
K
A
E
EI
I
K
KDPG
I
SISH
L
N
N
R
EK
TK
I
T
DAL
RQ
TY
P
L
T
ELL
R
V
L
G
LA
RS
S
Y
F
-----------
YHRAA
LK
A
G
D
K
Y
A
T
IRT
ML
T
DIF
N
SNY
Q
C
YG
Y
RRL
HA
M
L
RH
E
G
VR
L
SEKVVR
RL
MV
E
E
Q
L
V
V
S
R
N
R
RR
R
Y
S
SY
C
GEIG
P
AP
D
NL
IARD
F
K
A
E
Q
PNQ
K
W
LT
D
I
T
EFQ
L
P
A
G
KVW
L
SPV
V
D
CFDG
K
V
V
S
fig|340197.5.peg.1582
Escherichia coli F11 (118-381/428)
FEP
E
V
K
RQ
AV
MA
LCTR
Q
V
S
A
SE
I
A
R
R
IGV
S
RAV
L
Y
K
W
---
K
D
E
I
I
G
NS
A
YQ
T
MRKH
N
---
E
P
S
L
E
AE
RDA
L
R
E
E
V
AR
L
NQ
E
I
RR
R
QM
E
L
DIL
K
K
A
E
EI
I
K
KDPG
I
SISH
L
N
N
R
EK
TK
I
A
DAL
RQ
TY
P
L
T
ELL
H
V
L
G
LA
RSGY
F
-----------
YHRAA
LK
A
G
D
K
Y
A
T
IRT
ML
T
DIF
N
SNY
Q
C
YG
Y
RRL
HA
M
L
RH
E
G
GR
L
SEKVVR
RL
MV
E
E
Q
L
V
V
S
R
N
R
RR
R
Y
S
SY
C
GEIG
P
AP
D
NL
IARD
F
K
A
E
Q
PNQ
K
W
LT
D
I
T
EFQ
L
P
A
G
KVW
L
SPV
V
D
CFDG
K
V
V
S
fig|749550.3.peg.2854
Escherichia coli MS 200-1 (118-381/428)
FEP
E
V
K
RQ
AV
MA
LCTR
Q
V
S
A
SE
I
A
R
R
IGV
S
RAV
L
Y
K
W
---
K
D
E
I
I
G
NS
A
YQ
T
MRKH
N
---
E
P
S
L
E
AE
RDA
L
R
E
E
V
AR
L
NQ
E
I
RR
R
QM
E
L
DIL
K
K
A
E
EI
I
K
KDPG
I
SISH
L
N
N
R
EK
TK
I
A
DAL
RQ
TY
P
L
T
ELL
H
V
L
G
LA
RSGY
F
-----------
YHRAA
LK
A
G
D
K
Y
A
T
IRT
ML
T
DIF
N
SNY
Q
C
YG
Y
RRL
HA
M
L
RH
E
G
GR
L
SEKVVR
RL
MV
E
E
Q
L
V
V
S
R
N
R
RR
R
Y
S
SY
C
GEIG
P
AP
D
NL
IARD
F
K
A
E
Q
PNQ
K
W
LT
D
I
T
EFQ
L
P
A
G
KVW
L
SPV
V
D
CFDG
K
V
V
S
fig|656417.3.peg.1968
Escherichia coli M605 (118-379/512)
FEP
E
V
K
RQ
AV
MA
LCTR
Q
V
S
A
SE
I
A
R
R
IGV
S
R
T
V
L
Y
K
W
---
K
D
E
I
I
G
NS
A
YQ
T
MRKH
N
---
K
P
S
L
E
AE
RDA
L
R
E
E
V
AR
L
NQ
E
I
RR
Q
QM
E
P
DIL
K
K
T
E
EI
I
K
KAPG
-
-ISH
L
N
N
R
EK
TK
I
T
DAL
RQ
TY
S
L
T
ELL
R
V
P
G
LA
RS
S
Y
F
-----------
YHRA
V
LK
A
G
D
K
Y
A
T
IRT
ML
T
DIF
N
N
NY
Q
C
YG
Y
RRL
HA
M
L
RH
E
G
VR
L
SEKVVR
RL
M
M
E
E
Q
L
V
V
S
R
N
R
RR
R
Y
S
SY
C
GEIG
P
AP
D
NL
IARD
F
K
A
E
Q
PNQ
K
W
LT
D
I
T
EFQ
L
P
A
G
KVW
L
SP
I
V
D
CFDG
K
V
V
S
fig|340184.6.peg.1424
Escherichia coli B7A (118-381/510)
FEP
E
V
K
RQ
AV
MA
L
S
TR
Q
V
S
A
SE
I
A
R
R
IGV
S
RAV
L
Y
K
W
---
K
D
E
I
I
G
NS
A
YQ
T
MRKH
N
---
E
P
S
L
E
AE
RDA
L
R
E
E
V
AR
L
NQ
E
I
RR
R
QM
E
L
DIL
K
K
A
E
EI
I
K
KNPG
I
SISH
L
N
N
R
EK
TK
I
A
DAL
RQ
TY
P
L
T
ELL
H
V
L
S
LA
RS
S
Y
F
-----------
YHRAA
LK
A
G
D
K
Y
A
T
IRT
ML
T
DIF
N
SNY
Q
C
YG
Y
RRL
HA
M
L
RH
E
G
VR
L
SEKVVR
RL
MV
E
E
Q
L
V
V
S
R
N
R
RR
R
Y
S
SY
C
GEIG
P
AP
D
NL
IARD
F
K
A
E
Q
PNQ
K
W
LT
D
I
T
EFQ
L
P
A
G
KVW
L
SPV
V
D
CFDG
K
V
V
S
fig|679205.4.peg.1046
Escherichia coli MS 124-1 (125-381/512)
E
G
V
VQ
LCTR
Q
S
S
AQ
E
I
A
D
K
L
GV
C
R
GTL
Y
N
W
---
K
N
Q
L
LG
PC
A
PA
SM
-
KH
S
PKR
S
P
V
L
D
A
A
--
A
L
R
C
QV
ES
LR
Q
D
V
RR
L
KI
ER
EL
L
K
Q
A
H
EI
L
K
NGAD
I
DLHR
L
A
N
K
D
K
AV
L
V
E
ALHG
Q
YEL
P
ELL
C
H
V
G
LA
RS
S
Y
F
-----------
YHRA
RLKL
A
D
K
YL
D
V
R
R
SI
T
DIF
D
SNY
R
C
YG
Y
RR
V
Q
A
S
L
LK
EC
TG
I
SEKVVR
RL
M
K
QE
G
L
I
V
V
K
P
KRR
R
Y
N
SY
L
GEIGAAP
Q
NL
I
N
RD
F
H
A
A
APN
EK
W
LT
D
I
T
EFQ
I
P
S
G
KV
YL
SPV
I
D
CFDG
L
V
V
S
fig|749533.3.peg.3905
Escherichia coli MS 84-1 (125-381/512)
E
G
V
VQ
LCTR
Q
S
S
AQ
E
I
A
D
K
L
GV
C
R
GTL
Y
N
W
---
K
N
Q
L
LG
PC
A
PA
SM
-
KH
S
PKR
S
P
V
L
D
A
A
--
A
L
R
C
QV
ES
LR
Q
D
V
RR
L
KI
ER
EL
L
K
Q
A
H
EI
L
K
NGAD
I
DLHR
L
A
N
K
D
K
AV
L
V
E
ALHG
Q
YEL
P
ELL
C
H
V
G
LA
RS
S
Y
F
-----------
YHRA
RLKL
A
D
K
YL
D
V
R
R
SI
T
DIF
D
SNY
R
C
YG
Y
RR
V
Q
A
S
L
LK
EC
TG
I
SEKVVR
RL
M
K
QE
G
L
I
V
V
K
P
KRR
R
Y
N
SY
L
GEIGAAP
Q
NL
I
N
RD
F
H
A
A
APN
EK
W
LT
D
I
T
EFQ
I
P
S
G
KV
YL
SPV
I
D
CFDG
L
V
V
S
Consen1
Primary consensus
MSRKTQRyskEfKaeaV
vlenQ
SisEgA
rlsl
egtLg
Wvtaa
k
lG
g
tv
---
---
-
-
Ae
---
Le
ei
Lrk
lne
rlErdiLn
t
--
-
-
-
v
eK
l
eqwrqqfpi
amc
v
GvsRSgYynwvqhepsdrkqsderLKl
iKva
iRt
T
---
---
-
YGtRRlqt
L
ng
vgrdrlaRLrkel
L
c
q
rkfRattn
nhnlpva
NLlnqtF
p
aPNqvWvaDlTyva
q
GwlyLagi
Dvytc
iVg
Consen2
Secondary consensus
fep
v
rqg
lctr
aq
i
kigv
rav
y
---
k
i
a
smrkh
pkr
p
l
arda
r
qv
nq
rr
lel
k
a
ei
k
i
l
n
d
i
dalhgtyel
ell
h
la
s
f
-----------
yhraa
a
d
yl
v
r
dif
sny
c
y
vha
ec
sekvvr
mvqe
v
krr
y
sy
geigaap
iard
a
q
ek
lt
i
efq
p
kvw
spv
cfdg
v
s
Consensus 1
(when a gap)
Conservative difference
Consensus 2
(when a gap)
Nonconservative diff.
Other character