fig|1040638.4.peg.599
Escherichia coli O104:H4 str. LB226692
MDKYNLKDALLFISRGDTHE
I
L
I
E
TN
Q
RT
RPDVQ
S
NL
QE
L
LNL
--
YPDI
I
PKV
V
-
---
-
SL
-----
SELQ
EAG
QD
DENK
G
PK
E
RII
HLKDLADVS
ES
EKKVLSY
FET
A
RK
LGASDIHFLI
---
S
ES
IFKVRMRIFGELQ
T
VD
EDQPA
LGYSLCATAILSMADVTE
-
TSFFP
QR
EQDARLSP
Q
LMR
KI
GIFGARYSHRPTGDGLIAV
M
RLIPDDGD
K
VPTF
KQ
LGF
I
PEQIR
L
LN
V
MLRRPEGKIVLSGPTGSGKSTTLRSAC
R
VYL
---
--
DDN
Q
G
--
---
RHLLTIEDPLEGQILGATQTPI
I
CD
KS
DE
E
AVKLAWSRAISSAMRLDPDAIMEGEMRDL
V
SMMSTTYAAQTGHIVLTTLHTNSALGI
P
ERMITMGMNADLICDAQLLIGMISQRLVP
T
LCP
S
CR
I
PW
E
K
RVPE
LS
E
D
D
R
A
YLE
RH
C
N
KD
S
LCSTDNI
W
FRN
P
HGC
SD
C
N
HDVIINGRKRGEIGKGLTGRTVIAEVIEPDNRLFQILK
TR
GKVAAR
K
YWL
E
NM
H
GISRVEHLL
RR
IN
E
GLVDPL
E
AD
R
IIPLDEDERLSIDDA
fig|6666666.5357.peg.2816
Escherichia coli TY-2482
MDKYNLKDALLFISRGDTHE
I
L
I
E
TN
Q
RT
RPDVQ
S
NL
QE
L
LNL
--
YPDI
I
PKV
V
-
---
-
SL
-----
SELQ
EAG
QD
DENK
G
PK
E
RII
HLKDLADVS
ES
EKKVLSY
FET
A
RK
LGASDIHFLI
---
S
ES
IFKVRMRIFGELQ
T
VD
EDQPA
LGYSLCATAILSMADVTE
-
TSFFP
QR
EQDARLSP
Q
LMR
KI
GIFGARYSHRPTGDGLIAV
M
RLIPDDGD
K
VPTF
KQ
LGF
I
PEQIR
L
LN
V
MLRRPEGKIVLSGPTGSGKSTTLRSAC
R
VYL
---
--
DDN
Q
G
--
---
RHLLTIEDPLEGQILGATQTPI
I
CD
KS
DE
E
AVKLAWSRAISSAMRLDPDAIMEGEMRDL
V
SMMSTTYAAQTGHIVLTTLHTNSALGI
P
ERMITMGMNADLICDAQLLIGMISQRLVP
T
LCP
S
CR
I
PW
E
K
RVPE
LS
E
D
D
R
A
YLE
RH
C
N
KD
S
LCSTDNI
W
FRN
P
HGC
SD
C
N
HDVIINGRKRGEIGKGLTGRTVIAEVIEPDNRLFQILK
TR
GKVAAR
K
YWL
E
NM
H
GISRVEHLL
RR
IN
E
GLVDPL
E
AD
R
IIPLDEDERLSIDDA
fig|595495.4.peg.3704
Escherichia coli KO11
MDKYNLKDALLFISRGDTHE
I
L
I
E
TN
Q
RT
RPDVQ
S
NL
QE
L
LNL
--
YPDI
I
PKV
V
-
---
-
SL
-----
SELQ
EAG
QD
DENK
G
PK
E
RII
HLKDLADVS
ES
EKKVLSY
FET
A
RK
LGASDIHFLI
---
S
ES
IFKVRMRIFGELQ
T
VD
EDQPA
LGYSLCATAILSMADVTE
-
TSFFP
QR
EQDARLSP
Q
LMR
KI
GIFGARYSHRPTGDGLIAV
M
RLIPDDGD
K
VPTF
KQ
LGF
I
PEQIR
L
LN
V
MLRRPEGKIVLSGPTGSGKSTTLRSAC
R
VYL
---
--
DDN
Q
G
--
---
RHLLTIEDPLEGQILGATQTPI
I
CD
KS
DE
E
AVKLAWSRAISSAMRLDPDAIMEGEMRDL
V
SMMSTTYAAQTGHIVLTTLHTNSALGI
P
ERMITMGMNADLICDAQLLIGMISQRLVP
T
LCP
S
CR
I
PW
E
K
RVPE
LS
E
D
D
R
A
YLE
RH
C
N
KD
S
LCSTDNI
W
FRN
P
HGC
SD
C
N
HDVIINGRKRGEIGKGLTGRTVIAEVIEPDNRLFQILK
TR
GKVAAR
K
YWL
E
NM
H
GISRVEHLL
RR
IN
E
GLVDPL
E
AD
R
IIPLDEDERLSIDDA
fig|566546.3.peg.3415
Escherichia coli W
MDKYNLKDALLFISRGDTHE
I
L
I
E
TN
Q
RT
RPDVQ
S
NL
QE
L
LNL
--
YPDI
I
PKV
V
-
---
-
SL
-----
SELQ
EAG
QD
DENK
G
PK
E
RII
HLKDLADVS
ES
EKKVLSY
FET
A
RK
LGASDIHFLI
---
S
ES
IFKVRMRIFGELQ
T
VD
EDQPA
LGYSLCATAILSMADVTE
-
TSFFP
QR
EQDARLSP
Q
LMR
KI
GIFGARYSHRPTGDGLIAV
M
RLIPDDGD
K
VPTF
KQ
LGF
I
PEQIR
L
LN
V
MLRRPEGKIVLSGPTGSGKSTTLRSAC
R
VYL
---
--
DDN
Q
G
--
---
RHLLTIEDPLEGQILGATQTPI
I
CD
KS
DE
E
AVKLAWSRAISSAMRLDPDAIMEGEMRDL
V
SMMSTTYAAQTGHIVLTTLHTNSALGI
P
ERMITMGMNADLICDAQLLIGMISQRLVP
T
LCP
S
CR
I
PW
E
K
RVPE
LS
E
D
D
R
A
YLE
RH
C
N
KD
S
LCSTDNI
W
FRN
P
HGC
SD
C
N
HDVIINGRKRGEIGKGLTGRTVIAEVIEPDNRLFQILK
TR
GKVAAR
K
YWL
E
NM
H
GISRVEHLL
RR
IN
E
GLVDPL
E
AD
R
IIPLDEDERLSIDDA
fig|566546.4.peg.4763
Escherichia coli W
MDKYNLKDALLFISRGDTHE
I
L
I
E
TN
Q
RT
RPDVQ
S
NL
QE
L
LNL
--
YPDI
I
PKV
V
-
---
-
SL
-----
SELQ
EAG
QD
DENK
G
PK
E
RII
HLKDLADVS
ES
EKKVLSY
FET
A
RK
LGASDIHFLI
---
S
ES
IFKVRMRIFGELQ
T
VD
EDQPA
LGYSLCATAILSMADVTE
-
TSFFP
QR
EQDARLSP
Q
LMR
KI
GIFGARYSHRPTGDGLIAV
M
RLIPDDGD
K
VPTF
KQ
LGF
I
PEQIR
L
LN
V
MLRRPEGKIVLSGPTGSGKSTTLRSAC
R
VYL
---
--
DDN
Q
G
--
---
RHLLTIEDPLEGQILGATQTPI
I
CD
KS
DE
E
AVKLAWSRAISSAMRLDPDAIMEGEMRDL
V
SMMSTTYAAQTGHIVLTTLHTNSALGI
P
ERMITMGMNADLICDAQLLIGMISQRLVP
T
LCP
S
CR
I
PW
E
K
RVPE
LS
E
D
D
R
A
YLE
RH
C
N
KD
S
LCSTDNI
W
FRN
P
HGC
SD
C
N
HDVIINGRKRGEIGKGLTGRTVIAEVIEPDNRLFQILK
TR
GKVAAR
K
YWL
E
NM
H
GISRVEHLL
RR
IN
E
GLVDPL
E
AD
R
IIPLDEDERLSIDDA
fig|679207.4.peg.4569
Escherichia coli MS 107-1 (1-516/517)
MDKYNLKDALLFISRGDTHE
I
L
I
E
TN
Q
RT
RPDVQ
S
NL
QE
L
LKL
--
YPDI
N
PKV
V
-
---
-
SL
-----
SELQ
EAG
QD
EKNR
G
PK
E
RII
HLKDLADVS
ES
EKKVLSY
FET
A
RK
LGASDIHFLI
---
S
ES
IFKVRMRIFGELQ
T
VD
EDQPA
LGYSLCATAILSMADVTE
-
TSFFP
QR
EQDARLSP
Q
LMR
KI
GIFGARYSHRPTGDGLIAV
M
RLIPDDGD
K
VPTF
KQ
LGF
I
PEQIR
L
LN
I
MLRRPEGKIVLSGPTGSGKSTTLRSAC
R
VYL
---
--
DDN
Q
G
--
---
RHLLTIEDPLEGQILGATQTPI
I
CD
KS
DE
D
AVKLAWSRAISSAMRLDPDAIMEGEMRDL
I
SMMSTTYAAQTGHIVLTTLHTNSALGI
P
ERMITMGMNADLICDAQLLIGMISQRLVP
T
LCP
S
CR
I
PW
E
K
RAPE
LS
D
DER
D
YLE
RH
C
N
KD
S
LCSTDNI
W
FRN
H
HGC
SE
C
N
HDVIINGRKRGEIGKGLTGRTVIAEVIEPDNRLFQILK
TR
GKVAAR
K
YWL
E
NM
K
GISRVEHLL
RR
IN
E
GLVDPL
E
AD
R
IIPLDEDERLSIDD
fig|679205.4.peg.5011
Escherichia coli MS 124-1 (1-516/517)
MDKYNLKDALLFISRGDTHE
I
L
I
E
TN
Q
RT
RPDVQ
S
NL
QE
L
LKL
--
YPDI
N
PKV
V
-
---
-
SL
-----
SELQ
EAG
QD
EKNR
G
PK
E
RII
HLKDLADVS
ES
EKKVLSY
FET
A
RK
LGASDIHFLI
---
S
ES
IFKVRMRIFGELQ
T
VD
EDQPA
LGYSLCATAILSMADVTE
-
TSFFP
QR
EQDARLSP
Q
LMR
KI
GIFGARYSHRPTGDGLIAV
M
RLIPDDGD
K
VPTF
KQ
LGF
I
PEQIR
L
LN
I
MLRRPEGKIVLSGPTGSGKSTTLRSAC
R
VYL
---
--
DDN
Q
G
--
---
RHLLTIEDPLEGQILGATQTPI
I
CD
KS
DE
D
AVKLAWSRAISSAMRLDPDAIMEGEMRDL
I
SMMSTTYAAQTGHIVLTTLHTNSALGI
P
ERMITMGMNADLICDAQLLIGMISQRLVP
T
LCP
S
CR
I
PW
E
K
RAPE
LS
D
DER
D
YLE
RH
C
N
KD
S
LCSTDNI
W
FRN
H
HGC
SE
C
N
HDVIINGRKRGEIGKGLTGRTVIAEVIEPDNRLFQILK
TR
GKVAAR
K
YWL
E
NM
K
GISRVEHLL
RR
IN
E
GLVDPL
E
AD
R
IIPLDEDERLSIDD
fig|749533.3.peg.5235
Escherichia coli MS 84-1 (1-516/517)
MDKYNLKDALLFISRGDTHE
I
L
I
E
TN
Q
RT
RPDVQ
S
NL
QE
L
LKL
--
YPDI
N
PKV
V
-
---
-
SL
-----
SELQ
EAG
QD
EKNR
G
PK
E
RII
HLKDLADVS
ES
EKKVLSY
FET
A
RK
LGASDIHFLI
---
S
ES
IFKVRMRIFGELQ
T
VD
EDQPA
LGYSLCATAILSMADVTE
-
TSFFP
QR
EQDARLSP
Q
LMR
KI
GIFGARYSHRPTGDGLIAV
M
RLIPDDGD
K
VPTF
KQ
LGF
I
PEQIR
L
LN
I
MLRRPEGKIVLSGPTGSGKSTTLRSAC
R
VYL
---
--
DDN
Q
G
--
---
RHLLTIEDPLEGQILGATQTPI
I
CD
KS
DE
D
AVKLAWSRAISSAMRLDPDAIMEGEMRDL
I
SMMSTTYAAQTGHIVLTTLHTNSALGI
P
ERMITMGMNADLICDAQLLIGMISQRLVP
T
LCP
S
CR
I
PW
E
K
RAPE
LS
D
DER
D
YLE
RH
C
N
KD
S
LCSTDNI
W
FRN
H
HGC
SE
C
N
HDVIINGRKRGEIGKGLTGRTVIAEVIEPDNRLFQILK
TR
GKVAAR
K
YWL
E
NM
K
GISRVEHLL
RR
IN
E
GLVDPL
E
AD
R
IIPLDEDERLSIDD
fig|444454.5.peg.421
Escherichia coli O157:H7 str. EC4024 (1-516/517)
MDKYNLKDALLFISRGDTHE
I
L
I
E
TN
Q
RT
RPDVQ
S
NL
QE
L
LKL
--
YPDI
N
PKV
V
-
---
-
SL
-----
SELQ
EAG
QD
EKNR
G
PK
E
RII
HLKDLADVS
ES
EKKVLSY
FET
A
RK
LGASDIHFLI
---
S
ES
IFKVRMRIFGELQ
T
VD
EDQPA
LGYSLCATAILSMADVTE
-
TSFFP
QR
EQDARLSP
Q
LMR
KI
GIFGARYSHRPTGDGLIAV
M
RLIPDDGD
K
VPTF
KQ
LGF
I
PEQIR
L
LN
I
MLRRPEGKIVLSGPTGSGKSTTLRSAC
R
VYL
---
--
DDN
Q
G
--
---
RHLLTIEDPLEGQILGATQTPI
I
CD
KS
DE
D
AVKLAWSRAISSAMRLDPDAIMEGEMRDL
I
SMMSTTYAAQTGHIVLTTLHTNSALGI
P
ERMITMGMNADLICDAQLLIGMISQRLVP
T
LCP
S
CR
I
PW
E
K
RAPE
LS
D
DER
D
YLE
RH
C
N
KD
S
LCSTDNI
W
FRN
H
HGC
SE
C
N
HDVIINGRKRGEIGKGLTGRTVIAEVIEPDNRLFQILK
TR
GKVAAR
K
YWL
E
NM
K
GISRVEHLL
RR
IN
E
GLVDPL
E
AD
R
IIPLDEDERLSIDD
fig|478004.5.peg.4955
Escherichia coli O157:H7 str. EC4401 (1-516/517)
MDKYNLKDALLFISRGDTHE
I
L
I
E
TN
Q
RT
RPDVQ
S
NL
QE
L
LKL
--
YPDI
N
PKV
V
-
---
-
SL
-----
SELQ
EAG
QD
EKNR
G
PK
E
RII
HLKDLADVS
ES
EKKVLSY
FET
A
RK
LGASDIHFLI
---
S
ES
IFKVRMRIFGELQ
T
VD
EDQPA
LGYSLCATAILSMADVTE
-
TSFFP
QR
EQDARLSP
Q
LMR
KI
GIFGARYSHRPTGDGLIAV
M
RLIPDDGD
K
VPTF
KQ
LGF
I
PEQIR
L
LN
I
MLRRPEGKIVLSGPTGSGKSTTLRSAC
R
VYL
---
--
DDN
Q
G
--
---
RHLLTIEDPLEGQILGATQTPI
I
CD
KS
DE
D
AVKLAWSRAISSAMRLDPDAIMEGEMRDL
I
SMMSTTYAAQTGHIVLTTLHTNSALGI
P
ERMITMGMNADLICDAQLLIGMISQRLVP
T
LCP
S
CR
I
PW
E
K
RAPE
LS
D
DER
D
YLE
RH
C
N
KD
S
LCSTDNI
W
FRN
H
HGC
SE
C
N
HDVIINGRKRGEIGKGLTGRTVIAEVIEPDNRLFQILK
TR
GKVAAR
K
YWL
E
NM
K
GISRVEHLL
RR
IN
E
GLVDPL
E
AD
R
IIPLDEDERLSIDD
fig|478005.5.peg.4411
Escherichia coli O157:H7 str. EC4486 (1-516/517)
MDKYNLKDALLFISRGDTHE
I
L
I
E
TN
Q
RT
RPDVQ
S
NL
QE
L
LKL
--
YPDI
N
PKV
V
-
---
-
SL
-----
SELQ
EAG
QD
EKNR
G
PK
E
RII
HLKDLADVS
ES
EKKVLSY
FET
A
RK
LGASDIHFLI
---
S
ES
IFKVRMRIFGELQ
T
VD
EDQPA
LGYSLCATAILSMADVTE
-
TSFFP
QR
EQDARLSP
Q
LMR
KI
GIFGARYSHRPTGDGLIAV
M
RLIPDDGD
K
VPTF
KQ
LGF
I
PEQIR
L
LN
I
MLRRPEGKIVLSGPTGSGKSTTLRSAC
R
VYL
---
--
DDN
Q
G
--
---
RHLLTIEDPLEGQILGATQTPI
I
CD
KS
DE
D
AVKLAWSRAISSAMRLDPDAIMEGEMRDL
I
SMMSTTYAAQTGHIVLTTLHTNSALGI
P
ERMITMGMNADLICDAQLLIGMISQRLVP
T
LCP
S
CR
I
PW
E
K
RAPE
LS
D
DER
D
YLE
RH
C
N
KD
S
LCSTDNI
W
FRN
H
HGC
SE
C
N
HDVIINGRKRGEIGKGLTGRTVIAEVIEPDNRLFQILK
TR
GKVAAR
K
YWL
E
NM
K
GISRVEHLL
RR
IN
E
GLVDPL
E
AD
R
IIPLDEDERLSIDD
fig|409438.11.peg.5038
Escherichia coli SE11 (1-516/517)
MDKYNLKDALLFISRGDTHE
I
L
I
E
TN
Q
RT
RPDVQ
S
NL
QE
L
LKL
--
YPDI
N
PKV
V
-
---
-
SL
-----
SELQ
EAG
QD
EKNR
G
QK
E
RII
HLKDLADVS
ES
EKKVLSY
FET
A
RK
LGASDIHFLI
---
S
ES
IFKVRMRIFGELQ
T
VD
EDQPA
LGYSLCATAILSMADVTE
-
TSFFP
QR
EQDARLSP
Q
LMR
KI
GIFGARYSHRPTGDGLIAV
M
RLIPDDGD
K
VPTF
KQ
LGF
I
PEQIR
L
LN
I
MLRRPEGKIVLSGPTGSGKSTTLRSAC
R
VYL
---
--
DDN
Q
G
--
---
RHLLTIEDPLEGQILGATQTPI
I
CD
KS
DE
D
AVKLAWSRAISSAMRLDPDAIMEGEMRDL
I
SMMSTTYAAQTGHIVLTTLHTNSALGI
P
ERMITMGMNADLICDAQLLIGMISQRLVP
T
LCP
S
CR
I
PW
E
K
RAPE
LS
D
DER
D
YLE
RH
C
N
KD
S
LCSTDNI
W
FRN
H
HGC
SE
C
N
HDVIINGRKRGEIGKGLTGRTVIAEVIEPDNRLFQILK
TR
GKVAAR
K
YWL
E
NM
K
GISRVEHLL
RR
IN
E
GLVDPL
E
AD
R
IIPLDEDERLSIDD
fig|637388.3.peg.3474
Escherichia coli O157:H7 str. FRIK2000 (31-502/512)
V
Y
I
A
D
NS
K
GQ
R
A
-
VQ
A
YI
GT
L
NVK
--
YP
E
-
-
-
KV
N
-
ITW
TT
L
-----
DVIA
SRY
QD
SERR
S
DS
N
SSQ
HL
------
N
SN
Q
E
KV
I
SY
LAK
A
NN
LG
S
SD
L
H
ITPGRDG
SE
FTY
V
EA
R
VH
GEL
E
I
L
D
VIPRK
E
G
LE
L
LGA
A
YSG
M
S
DV
IKG
T
Q
F
D
P
AI
P
QDAR
IAE
N
FLK
PV
NL
FGARYSH
Y
P
CVG
G
VY
AV
F
RLI
K
DD
S
E
D
I
PTF
EE
LG
Y
M
P
Q
QI
Q
T
I
R
R
ML
Q
RPEG
I
IVLSGPTGSGKSTTLR
T
A
S
E
A
YL
STF
GFNH
N
D
N
MR
LPRKR
L
F
TIE
S
P
P
EG
R
I
P
GA
I
QT
AV
R
-
D
SV
D
-
-
----
G
W
VD
AI
K
SAMRLDPDAI
LN
GE
I
RD
H
A
S
A
LA
AIK
A
SM
TGH
L
L
LTTLH
A
N
D
AL
N
I
I
ER
LEMEN
I
Q
A
R
LI
A
D
PL
L
F
IG
LL
SQRLV
Q
K
LCP
Y
C
K
R
TY
A
E
MADK
LS
T
E
ER
K
L
I
E
EN
C
L
PE
Q
------
V
R
L
RN
L
D
GC
EH
C
Y
--------------
KG
V
TGRTVIAEV
VS
PD
A
R
F
FQ
LYR
QS
G
R
L
E
A
K
S
YW
H
Y
EL
G
GI
T
R
NQ
HLL
HL
IN
H
GLVDPL
S
A
H
F
I
S
P
I
DED
K
fig|562.375.peg.5432
Escherichia coli EC4100B (31-502/512)
V
Y
I
A
D
NS
K
GQ
R
A
-
VQ
A
YI
GT
L
NVK
--
YP
G
-
-
-
KV
N
-
ITW
TT
L
-----
DVIA
SRY
QD
SERR
S
DS
N
SSQ
HL
------
N
SN
Q
E
KV
I
SY
LAK
A
NN
LG
S
SD
L
H
ITPGRDG
SE
FTY
V
EA
R
VH
GEL
E
I
L
D
VIPRK
E
G
LE
L
LGA
A
YSG
M
S
DV
IKG
T
Q
F
D
P
AI
P
QDAR
IAE
N
FLK
PV
NL
FGARYSH
Y
P
CVG
G
VY
AV
F
RLI
K
DD
S
E
D
I
PTF
EE
LG
Y
M
P
Q
QI
Q
T
I
R
R
ML
Q
RPEG
I
IVLSGPTGSGKSTTLR
T
A
S
E
A
YL
STF
GFNH
N
D
N
MR
LPRKR
L
F
TIE
S
P
P
EG
R
I
P
GA
I
QT
AV
R
-
D
SV
D
-
-
----
G
W
VD
AI
K
SAMRLDPDAI
LN
GE
I
RD
H
A
S
A
LA
AIK
A
SM
TGH
L
L
LTTLH
A
N
D
AL
N
I
I
ER
LEMEN
I
Q
A
R
LI
A
D
PL
L
F
IG
LL
SQRLV
Q
K
LCP
Y
C
K
R
TY
A
E
MADK
LS
T
E
ER
K
L
I
E
EN
C
L
PE
Q
------
V
R
L
RN
L
D
GC
EH
C
Y
--------------
KG
V
TGRTVIAEV
VS
PD
A
R
F
FQ
LYR
QS
G
R
L
E
A
K
S
YW
H
Y
EL
G
GI
T
R
NQ
HLL
HL
IN
H
GLVDPL
S
A
H
F
I
S
P
I
DED
K
fig|749540.3.peg.2827
Escherichia coli MS 146-1 (31-502/512)
V
Y
I
A
D
NS
K
GQ
R
A
-
VQ
A
YI
GT
L
NVK
--
YP
G
-
-
-
KV
N
-
ITW
TT
L
-----
DVIA
SRY
QD
SERR
S
DS
N
SSQ
HL
------
N
SN
Q
E
KV
I
SY
LAK
A
NN
LG
S
SD
L
H
ITPGRDG
SE
FTY
V
EA
R
VH
GEL
E
I
L
D
VIPRK
E
G
LE
L
LGA
A
YSG
M
S
DV
IKG
T
Q
F
D
P
AI
P
QDAR
IAE
N
FLK
PV
NL
FGARYSH
Y
P
CVG
G
VY
AV
F
RLI
K
DD
S
E
D
I
PTF
EE
LG
Y
M
P
Q
QI
Q
T
I
R
R
ML
Q
RPEG
I
IVLSGPTGSGKSTTLR
T
A
S
E
A
YL
STF
GFNH
N
D
N
MR
LPRKR
L
F
TIE
S
P
P
EG
R
I
P
GA
I
QT
AV
R
-
D
SV
D
-
-
----
G
W
VD
AI
K
SAMRLDPDAI
LN
GE
I
RD
H
A
S
A
LA
AIK
A
SM
TGH
L
L
LTTLH
A
N
D
AL
N
I
I
ER
LEMEN
I
Q
A
R
LI
A
D
PL
L
F
IG
LL
SQRLV
Q
K
LCP
Y
C
K
R
TY
A
E
MADK
LS
T
E
ER
K
L
I
E
EN
C
L
PE
Q
------
V
R
L
RN
L
D
GC
EH
C
Y
--------------
KG
V
TGRTVIAEV
VS
PD
A
R
F
FQ
LYR
QS
G
R
L
E
A
K
S
YW
H
Y
EL
G
GI
T
R
NQ
HLL
HL
IN
H
GLVDPL
S
A
H
F
I
S
P
I
DED
K
fig|444454.5.peg.880
Escherichia coli O157:H7 str. EC4024 (31-502/512)
V
Y
I
A
D
NS
K
GQ
R
A
-
VQ
A
YI
GT
L
NVK
--
YP
G
-
-
-
KV
N
-
ITW
TT
L
-----
DVIA
SRY
QD
SERR
S
DS
N
SSQ
HL
------
N
SN
Q
E
KV
I
SY
LAK
A
NN
LG
S
SD
L
H
ITPGRDG
SE
FTY
V
EA
R
VH
GEL
E
I
L
D
VIPRK
E
G
LE
L
LGA
A
YSG
M
S
DV
IKG
T
Q
F
D
P
AI
P
QDAR
IAE
N
FLK
PV
NL
FGARYSH
Y
P
CVG
G
VY
AV
F
RLI
K
DD
S
E
D
I
PTF
EE
LG
Y
M
P
Q
QI
Q
T
I
R
R
ML
Q
RPEG
I
IVLSGPTGSGKSTTLR
T
A
S
E
A
YL
STF
GFNH
N
D
N
MR
LPRKR
L
F
TIE
S
P
P
EG
R
I
P
GA
I
QT
AV
R
-
D
SV
D
-
-
----
G
W
VD
AI
K
SAMRLDPDAI
LN
GE
I
RD
H
A
S
A
LA
AIK
A
SM
TGH
L
L
LTTLH
A
N
D
AL
N
I
I
ER
LEMEN
I
Q
A
R
LI
A
D
PL
L
F
IG
LL
SQRLV
Q
K
LCP
Y
C
K
R
TY
A
E
MADK
LS
T
E
ER
K
L
I
E
EN
C
L
PE
Q
------
V
R
L
RN
L
D
GC
EH
C
Y
--------------
KG
V
TGRTVIAEV
VS
PD
A
R
F
FQ
LYR
QS
G
R
L
E
A
K
S
YW
H
Y
EL
G
GI
T
R
NQ
HLL
HL
IN
H
GLVDPL
S
A
H
F
I
S
P
I
DED
K
fig|562.373.peg.669
Escherichia coli 1125A (31-502/512)
V
Y
I
A
D
NS
K
GQ
R
A
-
VQ
A
YI
GT
L
NVK
--
YP
G
-
-
-
KV
N
-
ITW
TT
L
-----
DVIA
SRY
QD
SERR
S
DS
N
SSQ
HL
------
N
SN
Q
E
KV
I
SY
LAK
A
NN
LG
S
SD
L
H
ITPGRDG
SE
FTY
I
EA
R
VH
GEL
E
I
L
D
VIPRK
E
G
LE
L
LGA
A
YSG
M
S
DV
IKG
T
Q
F
D
P
AI
P
QDAR
IAE
N
FLK
PV
NL
FGARYSH
Y
P
CVG
G
VY
AV
F
RLI
K
DD
S
E
D
I
PTF
EE
LG
Y
M
P
Q
QI
Q
T
I
R
R
ML
Q
RPEG
I
IVLSGPTGSGKSTTLR
T
A
S
E
A
YL
STF
GFNH
N
D
N
MR
LPRKR
L
F
TIE
S
P
P
EG
R
I
P
GA
I
QT
AV
R
-
D
SV
D
-
-
----
G
W
VD
AI
K
SAMRLDPDAI
LN
GE
I
RD
H
A
S
A
LA
AIK
A
SM
TGH
L
L
LTTLH
A
N
D
AL
N
I
I
ER
LEMEN
I
Q
A
R
LI
A
D
PL
L
F
IG
LL
SQRLV
Q
K
LCP
Y
C
K
R
TY
A
E
MADK
LS
T
E
ER
K
L
I
E
EN
C
L
PE
Q
------
V
R
L
RN
L
D
GC
EH
C
Y
--------------
KG
V
TGRTVIAEV
VS
PD
A
R
F
FQ
LYR
QS
G
R
L
E
A
K
S
YW
H
Y
EL
G
GI
T
R
NQ
HLL
HL
IN
H
GLVDPL
S
A
H
F
I
S
P
I
DED
K
fig|749548.3.peg.5347
Escherichia coli MS 196-1 (24-496/502)
G
QI
H
V
R
V
V
E
GK
K
HL
R
A
-
VQ
D
Y
L
TR
L
CSR
--
YP
G
-
-
-
KV
S
P
FEF
TT
L
-----
DVIA
RLR
Q
E
TVIS
G
VE
N
G--
-
I
------
N
PV
Q
Q
K
M
L
G
Y
ISH
A
AT
L
S
ASD
L
H
ITPGRD
S
TD
FTYLEA
R
VH
GEL
E
L
L
D
IVRKD
E
G
LE
L
LGATYSG
M
T
DV
IKG
T
Q
F
D
P
GV
P
QDARL
AE
R
FLK
LA
G
L
FGARYSH
Y
P
CVG
GL
Y
AV
L
RLI
K
DD
S
Q
H
I
PTF
SM
LG
Y
H
PEQ
E
R
A
V
R
R
ML
Q
RPEG
IVI
LSGPTGSGKSTTLR
T
A
S
A
A
YL
EQY
GFN
D
T
G
G
IL
LPR
R
R
L
F
TIE
S
P
P
EG
R
I
P
GA
I
QT
AV
M
-
D
TA
Q
-
-
----
G
W
VDSVK
SA
L
RLDPDAI
LN
GE
I
RD
H
A
S
A
IT
AIK
AA
M
TGH
L
M
LTTLH
A
N
DPIN
I
L
ER
LEME
G
V
Q
A
RM
I
A
D
P
QL
F
IG
LL
SQRLV
Q
V
I
CP
H
CR
L
PW
H
E
VESS
RT
D
E
ER
R
L
V
E
NF
C
Q
P
D
A
------
V
Y
L
RN
H
N
GC
PH
C
W
--------------
R
G
VN
GRTVIAEVI
S
PD
AKF
FQI
YR
EK
G
R
I
E
A
K
T
YW
H
R
EL
G
G
MT
R
NQ
HLL
GK
IN
S
G
Q
VDPL
A
A
H
Y
I
S
P
V
DED
fig|749550.3.peg.4114
Escherichia coli MS 200-1 (24-496/502)
G
QI
H
V
R
V
V
E
GK
K
HL
R
A
-
VQ
D
Y
L
TR
L
CSR
--
YP
G
-
-
-
KV
S
P
FEF
TT
L
-----
DVIA
RLR
Q
E
TVIS
G
VE
N
G--
-
I
------
N
PV
Q
Q
K
M
L
G
Y
ISH
A
AT
L
S
ASD
L
H
ITPGRD
S
TD
FTYLEA
R
VH
GEL
E
L
L
D
IVRKD
E
G
LE
L
LGATYSG
M
T
DV
IKG
T
Q
F
D
P
GV
P
QDARL
AE
R
FLK
LA
G
L
FGARYSH
Y
P
CVG
GL
Y
AV
L
RLI
K
DD
S
Q
H
I
PTF
SM
LG
Y
H
PEQ
E
R
A
V
R
R
ML
Q
RPEG
IVI
LSGPTGSGKSTTLR
T
A
S
A
A
YL
EQY
GFN
D
T
G
G
IL
LPR
R
R
L
F
TIE
S
P
P
EG
R
I
P
GA
I
QT
AV
M
-
D
TA
Q
-
-
----
G
W
VDSVK
SA
L
RLDPDAI
LN
GE
I
RD
H
A
S
A
IT
AIK
AA
M
TGH
L
M
LTTLH
A
N
DPIN
I
L
ER
LEME
G
V
Q
A
RM
I
A
D
P
QL
F
IG
LL
SQRLV
Q
V
I
CP
H
CR
L
PW
H
E
VESS
RT
D
E
ER
R
L
V
E
NF
C
Q
P
D
A
------
V
Y
L
RN
H
N
GC
PH
C
W
--------------
R
G
VN
GRTVIAEVI
S
PD
AKF
FQI
YR
EK
G
R
I
E
A
K
T
YW
H
R
EL
G
G
MT
R
NQ
HLL
GK
IN
S
G
Q
VDPL
A
A
H
Y
I
S
P
V
DED
fig|749527.3.peg.4671
Escherichia coli MS 21-1 (24-496/502)
G
QI
H
V
R
V
V
E
GK
K
HL
R
A
-
VQ
D
Y
L
TR
L
CSR
--
YP
G
-
-
-
KV
S
P
FEF
TT
L
-----
DVIA
RLR
Q
E
TVIS
G
VE
N
G--
-
I
------
N
PV
Q
Q
K
M
L
G
Y
ISH
A
AT
L
S
ASD
L
H
ITPGRD
S
TD
FTYLEA
R
VH
GEL
E
L
L
D
IVRKD
E
G
LE
L
LGATYSG
M
T
DV
IKG
T
Q
F
D
P
GV
P
QDARL
AE
R
FLK
LA
G
L
FGARYSH
Y
P
CVG
GL
Y
AV
L
RLI
K
DD
S
Q
H
I
PTF
SM
LG
Y
H
PEQ
E
R
A
V
R
R
ML
Q
RPEG
IVI
LSGPTGSGKSTTLR
T
A
S
A
A
YL
EQY
GFN
D
T
G
G
IL
LPR
R
R
L
F
TIE
S
P
P
EG
R
I
P
GA
I
QT
AV
M
-
D
TA
Q
-
-
----
G
W
VDSVK
SA
L
RLDPDAI
LN
GE
I
RD
H
A
S
A
IT
AIK
AA
M
TGH
L
M
LTTLH
A
N
DPIN
I
L
ER
LEME
G
V
Q
A
RM
I
A
D
P
QL
F
IG
LL
SQRLV
Q
V
I
CP
H
CR
L
PW
H
E
VESS
RT
D
E
ER
R
L
V
E
NF
C
Q
P
D
A
------
V
Y
L
RN
H
N
GC
PH
C
W
--------------
R
G
VN
GRTVIAEVI
S
PD
AKF
FQI
YR
EK
G
R
I
E
A
K
T
YW
H
R
EL
G
G
MT
R
NQ
HLL
GK
IN
S
G
Q
VDPL
A
A
H
Y
I
S
P
V
DED
fig|478005.5.peg.4325
Escherichia coli O157:H7 str. EC4486 (24-496/502)
G
QI
H
V
R
V
V
E
GK
K
HL
R
A
-
VQ
D
Y
L
TR
L
CSR
--
YP
G
-
-
-
KV
S
P
FEF
TT
L
-----
DVIA
RLR
Q
E
TVIS
G
VE
N
G--
-
I
------
N
PV
Q
Q
K
M
L
G
Y
ISH
A
AT
L
S
ASD
L
H
ITPGRD
S
TD
FTYLEA
R
VH
GEL
E
L
L
D
IVRKD
E
G
LE
L
LGATYSG
M
T
DV
IKG
T
Q
F
D
P
GV
P
QDARL
AE
R
FLK
LA
G
L
FGARYSH
Y
P
CVG
GL
Y
AV
L
RLI
K
DD
S
Q
H
I
PTF
SM
LG
Y
H
PEQ
E
R
A
V
R
R
ML
Q
RPEG
IVI
LSGPTGSGKSTTLR
T
A
S
A
A
YL
EQY
GFN
D
T
G
G
IL
LPR
R
R
L
F
TIE
S
P
P
EG
R
I
P
GA
I
QT
AV
M
-
D
TA
Q
-
-
----
G
W
VDSVK
SA
L
RLDPDAI
LN
GE
I
RD
H
A
S
A
IT
AIK
AA
M
TGH
L
M
LTTLH
A
N
DPIN
I
L
ER
LEME
G
V
Q
A
RM
I
A
D
P
QL
F
IG
LL
SQRLV
Q
V
I
CP
H
CR
L
PW
H
E
VESS
RT
D
E
ER
R
L
V
E
NF
C
Q
P
D
A
------
V
Y
L
RN
H
N
GC
PH
C
W
--------------
R
G
VN
GRTVIAEVI
S
PD
AKF
FQI
YR
EK
G
R
I
E
A
K
T
YW
H
R
EL
G
G
MT
R
NQ
HLL
GK
IN
S
G
Q
VDPL
A
A
H
Y
I
S
P
V
DED
fig|656440.3.peg.4193
Escherichia coli TA206 (27-502/512)
H
R
V
C
F
P
VT
E
TS
N
P
EI
Q
T
F
I
TG
L
LRT
TGQ
P
V
I
P
EP
V
S
P
EAF
RD
L
QNDAG
D
A
L
R
HDG
S
E
HSR-
-
--
-
---
-
-
------
S
EV
Q
T
R
VL
N
M
FRE
A
RR
V
GASDIH
IT
V
---
F
VA
H
T
RI
E
MRI
N
G
L
L
Y
P
V
A
TLSRD
E
G
I
S
W
L
M
T
I
Y
Q
SM
S
D
LSD
-
NM
F
KA
YM
P
QDARL
KQ
E
FL
Q
DV
G
L
FGARY
A
H
IN
T
PK
G
V
F
AV
M
RLIPDDG
S
A
P
P
S
L
ET
LGF
L
P
A
QI
A
V
IH
T
ML
AS
P
D
A
I
I
I
N
SGPTGSGKSTT
G
RS
FM
A
LW
L
---
--
Q
H
G
N
G
--
--
Q
R
R
II
T
Q
EDP
V
EG
EV
E
GA
I
H
T
S
V
T
A
D
RS
S
E
E
D
I
N
LAW
L
R
GRR
A
M
L
RLDPDA
V
YI
GE
I
RD
H
D
S
A
M
A
AI
NF
A
ES
GHIVLTT
Q
H
A
NS
P
LG
N
L
N
R
L
QI
I
G
V
PQGF
L
RS
SR
L
F
Q
G
L
I
A
QRL
L
P
T
LCP
H
C
A
R
T
R
E
E
--AG
L
T
P
E
QQ
Q
F
T
D
RW
F
T
P
Q
Q
---
Q
E
A
L
R
FRN
P
D
GC
SE
C
I
RP
V
M
GTATS
-----
H
GL
K
GRTV
A
AEV
MK
TSPE
I
L
R
TCH
DE
G
E
D
AAR
T
L
WL
R
Q-
G
GIS
LS
Q
H
AR
HH
V
L
A
G
Q
VDP
F
M
A
N
D
I
V
P
F
ED
Consen1
Primary consensus
MDKYNLKDALLFISRGdtHe
l
e
q
RpdVQ
nl
L
--
YPdi
pKV
-
-
sL
-----
selq
Qd
g
e
hlkdladvs
ekKvlsY
A
LgaSDiHfli
---
s
ifkvrmRifGELq
vD
lGysLcatailsMaDVte
-
TsFfP
eQDARlsp
lmr
giFGARYSHrPtgdGliAV
RLIpDDgd
vPTF
LGf
PeQir
ln
MLrRPEGkivLSGPTGSGKSTTLRsAc
vYL
--
ddn
g
---
rhLlTIEdPlEGqIlGAtQTpi
cD
de
avklaWsraisSAmRLDPDAImeGEmRDl
SmmsttyAaqTGHivLTTLHtNsalgI
ERmitmgmnAdlIcDaqLlIGmiSQRLVp
lCP
Cr
pw
k
ls
deR
ylE
C
kd
lcstdni
fRN
hGC
C
hdviingrkrgeigkGltGRTVIAEViePDnrlFQilk
GkvaAr
YWl
nm
GisRveHLL
IN
GlVDPL
Ad
IiPlDEDeRLSIDDA
Consen2
Secondary consensus
qi
v
d
k
a
-
yi
g
-
-
p
tt
dvia
e
s
n
-
i
------
n
q
mig
ss
l
itpgrdg
ftylea
vh
e
l
e
le
lgatysg
ikg
q
d
p
iae
flk
nl
y
cvg
vy
k
s
i
y
q
eq
r
q
ivi
t
s
a
gfnht
n
lprkr
f
s
p
r
p
i
av
-
q
-
----
g
vdsvk
l
ln
i
h
a
aik
sm
l
a
dpin
lemen
q
rm
a
pl
f
ll
q
i
k
ty
e
rt
ed
l
pe
------
v
l
--------------
r
vn
vs
akf
lyr
r
e
k
h
el
mt
nq
q
h
s
k
Consensus 1
(when a gap)
Conservative difference
Consensus 2
(when a gap)
Nonconservative diff.
Other character