fig|340185.3.peg.4235
Escherichia coli E22 (48-361/361)
MRDAWTDFGRK
W
H
P
F
A
E
-
-
LA
T
DCI
E
SL
RE
N
SGEN
S
L
E
Y
TL
GL
WVP
Q
EE
AA
V
ISAG
I
R
S
GSI
V
D
AL
Q
F
A
TTLTDA
K
K
Q
L
HQ
A
I
WQMA
IYP
VG
LL
IM
M
TG
TL
Y
VL
N
T
E
LIP
VL
S
KI
S
S
P
D
S
WS
GA
L
GF
L
YGL
S
L
FV
D
N
YG
AICAVLFAV
V
TG
V
I
S
W
SL
KN
W
K
S
--
--
R
SL
A
D
N
I
M
PWS
I
Y
KD
IQ
G
A
A
FL
L
NMA
AL
L
K
A
K
MT
TLN
S
L
NV
L
Q
D
F
A
SP
-
-
WL
ST
R
L
DS
I
I
YR
V
R
Q
G
D
HL
G
L
A
L
R
Q
CGY
Q
FPSR
E
A
A
N
F
L
S
L
L
Q
-
GD
G
A
TEL
I
G
NY
GQ
RWL
V
QTL
ER
VK
KR
A
AV
VR
L
I
M
LIF
LV
M
SL
L
L
L
V
M
A
V
VD
I
Q
SI
G
DNSMGN
L
fig|340185.4.peg.4467
Escherichia coli E22 (48-361/361)
MRDAWTDFGRK
W
H
P
F
A
E
-
-
LA
T
DCI
E
SL
RE
N
SGEN
S
L
E
Y
TL
GL
WVP
Q
EE
AA
V
ISAG
I
R
S
GSI
V
D
AL
Q
F
A
TTLTDA
K
K
Q
L
HQ
A
I
WQMA
IYP
VG
LL
IM
M
TG
TL
Y
VL
N
T
E
LIP
VL
S
KI
S
S
P
D
S
WS
GA
L
GF
L
YGL
S
L
FV
D
N
YG
AICAVLFAV
V
TG
V
I
S
W
SL
KN
W
K
S
--
--
R
SL
A
D
N
I
M
PWS
I
Y
KD
IQ
G
A
A
FL
L
NMA
AL
L
K
A
K
MT
TLN
S
L
NV
L
Q
D
F
A
SP
-
-
WL
ST
R
L
DS
I
I
YR
V
R
Q
G
D
HL
G
L
A
L
R
Q
CGY
Q
FPSR
E
A
A
N
F
L
S
L
L
Q
-
GD
G
A
TEL
I
G
NY
GQ
RWL
V
QTL
ER
VK
KR
A
AV
VR
L
I
M
LIF
LV
M
SL
L
L
L
V
M
A
V
VD
I
Q
SI
G
DNSMGN
L
fig|595495.4.peg.3705
Escherichia coli KO11 (48-361/361)
MRDAWTDFGRK
W
H
P
F
A
E
-
-
LA
T
DCI
E
SL
RE
N
SGEN
S
L
E
Y
TL
GL
WVP
Q
EE
AA
V
ISAG
I
R
S
GSI
V
D
AL
Q
F
A
TTLTDA
K
K
Q
L
HQ
A
I
WQMA
IYP
VG
LL
IM
M
TG
TL
Y
VL
N
T
E
LIP
VL
S
KI
S
S
P
D
S
WS
GA
L
GF
L
YGL
S
V
FV
D
N
YG
AICAVLFAV
V
TG
V
I
S
W
SL
KN
W
K
S
--
--
R
SL
A
D
N
I
M
PWS
I
Y
KD
IQ
G
A
A
FL
L
NMA
AL
L
K
A
K
MT
TLN
S
L
NV
L
Q
D
F
A
SP
-
-
WL
ST
R
L
DS
I
I
YR
V
R
Q
G
D
HL
G
L
A
L
R
Q
CGY
Q
FPSR
E
A
A
N
F
L
S
L
L
Q
-
GD
G
A
TEL
I
G
NY
GQ
RWL
V
QTL
ER
VK
KR
A
AV
VR
L
I
M
LIF
LV
M
SL
L
L
L
V
M
A
V
VD
I
Q
SI
G
DNSMGN
L
fig|566546.3.peg.3416
Escherichia coli W (48-361/361)
MRDAWTDFGRK
W
H
P
F
A
E
-
-
LA
T
DCI
E
SL
RE
N
SGEN
S
L
E
Y
TL
GL
WVP
Q
EE
AA
V
ISAG
I
R
S
GSI
V
D
AL
Q
F
A
TTLTDA
K
K
Q
L
HQ
A
I
WQMA
IYP
VG
LL
IM
M
TG
TL
Y
VL
N
T
E
LIP
VL
S
KI
S
S
P
D
S
WS
GA
L
GF
L
YGL
S
V
FV
D
N
YG
AICAVLFAV
V
TG
V
I
S
W
SL
KN
W
K
S
--
--
R
SL
A
D
N
I
M
PWS
I
Y
KD
IQ
G
A
A
FL
L
NMA
AL
L
K
A
K
MT
TLN
S
L
NV
L
Q
D
F
A
SP
-
-
WL
ST
R
L
DS
I
I
YR
V
R
Q
G
D
HL
G
L
A
L
R
Q
CGY
Q
FPSR
E
A
A
N
F
L
S
L
L
Q
-
GD
G
A
TEL
I
G
NY
GQ
RWL
V
QTL
ER
VK
KR
A
AV
VR
L
I
M
LIF
LV
M
SL
L
L
L
V
M
A
V
VD
I
Q
SI
G
DNSMGN
L
fig|566546.4.peg.4762
Escherichia coli W (48-361/361)
MRDAWTDFGRK
W
H
P
F
A
E
-
-
LA
T
DCI
E
SL
RE
N
SGEN
S
L
E
Y
TL
GL
WVP
Q
EE
AA
V
ISAG
I
R
S
GSI
V
D
AL
Q
F
A
TTLTDA
K
K
Q
L
HQ
A
I
WQMA
IYP
VG
LL
IM
M
TG
TL
Y
VL
N
T
E
LIP
VL
S
KI
S
S
P
D
S
WS
GA
L
GF
L
YGL
S
V
FV
D
N
YG
AICAVLFAV
V
TG
V
I
S
W
SL
KN
W
K
S
--
--
R
SL
A
D
N
I
M
PWS
I
Y
KD
IQ
G
A
A
FL
L
NMA
AL
L
K
A
K
MT
TLN
S
L
NV
L
Q
D
F
A
SP
-
-
WL
ST
R
L
DS
I
I
YR
V
R
Q
G
D
HL
G
L
A
L
R
Q
CGY
Q
FPSR
E
A
A
N
F
L
S
L
L
Q
-
GD
G
A
TEL
I
G
NY
GQ
RWL
V
QTL
ER
VK
KR
A
AV
VR
L
I
M
LIF
LV
M
SL
L
L
L
V
M
A
V
VD
I
Q
SI
G
DNSMGN
L
fig|6666666.5357.peg.1729
Escherichia coli TY-2482 (48-361/361)
MRDAWTDFGRK
W
H
P
F
A
E
-
-
LA
T
DCI
E
SL
RE
N
SGEN
S
L
E
Y
TL
GL
WVP
Q
EE
AA
V
ISAG
I
R
S
GSI
V
D
AL
Q
F
A
TTLTDA
K
K
Q
L
HQ
A
I
WQMA
IYP
VG
LL
IM
M
TG
TL
Y
VL
N
T
E
LIP
VL
S
KI
S
S
P
D
S
WS
GA
L
GF
L
YGL
S
L
FV
D
N
YG
AICAVLFAV
V
TG
V
I
S
W
SL
KN
W
K
S
--
--
R
SL
A
D
N
I
M
PWS
I
Y
KD
IQ
G
A
A
FL
L
NMA
AL
L
K
A
K
MT
TLN
S
L
NV
L
Q
D
F
A
SP
-
-
WL
ST
R
L
DS
I
I
YR
V
R
Q
G
G
HL
G
L
A
L
R
Q
CGY
Q
FPSR
E
A
A
N
F
L
S
L
L
Q
-
GD
G
A
TEL
I
G
NY
GQ
RWL
V
QTL
ER
VK
KR
A
AV
VR
L
I
M
LIF
LV
M
SL
L
L
L
V
M
A
V
VD
I
Q
SI
G
DNSMGN
L
fig|1040638.4.peg.598
Escherichia coli O104:H4 str. LB226692
MRDAWTDFGRK
W
H
P
F
A
E
-
-
LA
T
DCI
E
SL
RE
N
SGEN
S
L
E
Y
TL
GL
WVP
Q
EE
AA
V
ISAG
I
R
S
GSI
V
D
AL
Q
F
A
TTLTDA
K
K
Q
L
HQ
A
I
WQMA
IYP
VG
LL
IM
M
TG
TL
Y
VL
N
T
E
LIP
VL
S
KI
S
S
P
D
S
WS
GA
L
GF
L
YGL
S
L
FV
D
N
YG
AICAVLFAV
V
TG
V
I
S
W
SL
KN
W
K
S
--
--
R
SL
A
D
N
I
M
PWS
I
Y
KD
IQ
G
A
A
FL
L
NMA
AL
L
K
A
K
MT
TLN
S
L
NV
L
Q
D
F
A
SP
-
-
WL
ST
R
L
DS
I
I
YR
V
R
Q
G
D
HL
G
L
A
L
R
Q
CGY
Q
FPSR
E
A
A
N
F
L
S
L
L
Q
-
GD
G
A
TEL
I
G
NY
GQ
RWL
V
QTL
ER
VK
KR
A
AV
VR
L
I
M
LIF
LV
M
SL
L
L
L
V
M
A
V
VD
I
Q
SI
G
DNSMGN
L
fig|679207.4.peg.4568
Escherichia coli MS 107-1 (48-365/365)
MRDAWTDFGRK
W
H
P
F
A
E
-
-
LA
T
DCI
E
SL
RE
N
SGEN
S
L
E
Y
TL
SL
WVP
Q
EE
AA
V
ISAG
I
R
S
GSI
V
D
AL
Q
F
A
TTLTDA
K
E
Q
I
HQ
A
I
WQMA
IYP
VG
LL
IM
M
TG
TL
Y
VL
N
T
E
LIP
EL
S
KI
S
S
P
D
S
WS
GA
L
GF
L
YGL
S
V
FV
D
N
YG
AICAVLFAV
I
TG
LI
S
W
SL
PN
W
K
SPD
SV
R
TF
A
D
K
I
M
PWS
I
YQ
D
IQ
G
A
T
FL
L
NMA
AL
L
K
A
K
MT
TLN
S
L
NI
L
Q
E
F
A
SP
-
-
WL
ST
R
L
DS
I
I
YR
V
R
Q
G
D
HL
G
L
A
L
R
Q
CGY
Q
FPSR
E
A
A
N
F
L
S
L
L
Q
-
GD
G
A
TEL
I
S
NY
GQ
RWL
S
QTL
QR
VK
KR
A
NV
I
R
L
I
M
LIF
LV
M
SL
M
L
L
V
F
AI
MD
I
Q
SISDNSMGNF
fig|679205.4.peg.5012
Escherichia coli MS 124-1 (48-365/365)
MRDAWTDFGRK
W
H
P
F
A
E
-
-
LA
T
DCI
E
SL
RE
N
SGEN
S
L
E
Y
TL
SL
WVP
Q
EE
AA
V
ISAG
I
R
S
GSI
V
D
AL
Q
F
A
TTLTDA
K
E
Q
I
HQ
A
I
WQMA
IYP
VG
LL
IM
M
TG
TL
Y
VL
N
T
E
LIP
EL
S
KI
S
S
P
D
S
WS
GA
L
GF
L
YGL
S
V
FV
D
N
YG
AICAVLFAV
I
TG
LI
S
W
SL
PN
W
K
SPD
SV
R
TF
A
D
K
I
M
PWS
I
YQ
D
IQ
G
A
T
FL
L
NMA
AL
L
K
A
K
MT
TLN
S
L
NI
L
Q
E
F
A
SP
-
-
WL
ST
R
L
DS
I
I
YR
V
R
Q
G
D
HL
G
L
A
L
R
Q
CGY
Q
FPSR
E
A
A
N
F
L
S
L
L
Q
-
GD
G
A
TEL
I
S
NY
GQ
RWL
S
QTL
QR
VK
KR
A
NV
I
R
L
I
M
LIF
LV
M
SL
M
L
L
V
F
AI
MD
I
Q
SISDNSMGNF
fig|749533.3.peg.5234
Escherichia coli MS 84-1 (48-365/365)
MRDAWTDFGRK
W
H
P
F
A
E
-
-
LA
T
DCI
E
SL
RE
N
SGEN
S
L
E
Y
TL
SL
WVP
Q
EE
AA
V
ISAG
I
R
S
GSI
V
D
AL
Q
F
A
TTLTDA
K
E
Q
I
HQ
A
I
WQMA
IYP
VG
LL
IM
M
TG
TL
Y
VL
N
T
E
LIP
EL
S
KI
S
S
P
D
S
WS
GA
L
GF
L
YGL
S
V
FV
D
N
YG
AICAVLFAV
I
TG
LI
S
W
SL
PN
W
K
SPD
SV
R
TF
A
D
K
I
M
PWS
I
YQ
D
IQ
G
A
T
FL
L
NMA
AL
L
K
A
K
MT
TLN
S
L
NI
L
Q
E
F
A
SP
-
-
WL
ST
R
L
DS
I
I
YR
V
R
Q
G
D
HL
G
L
A
L
R
Q
CGY
Q
FPSR
E
A
A
N
F
L
S
L
L
Q
-
GD
G
A
TEL
I
S
NY
GQ
RWL
S
QTL
QR
VK
KR
A
NV
I
R
L
I
M
LIF
LV
M
SL
M
L
L
V
F
AI
MD
I
Q
SISDNSMGNF
fig|444454.5.peg.420
Escherichia coli O157:H7 str. EC4024 (48-365/365)
MRDAWTDFGRK
W
H
P
F
A
E
-
-
LA
T
DCI
E
SL
RE
N
SGEN
S
L
E
Y
TL
SL
WVP
Q
EE
AA
V
ISAG
I
R
S
GSI
V
D
AL
Q
F
A
TTLTDA
K
E
Q
I
HQ
A
I
WQMA
IYP
VG
LL
IM
M
TG
TL
Y
VL
N
T
E
LIP
EL
S
KI
S
S
P
D
S
WS
GA
L
GF
L
YGL
S
V
FV
D
N
YG
AICAVLFAV
I
TG
LI
S
W
SL
PN
W
K
SPD
SV
R
TF
A
D
K
I
M
PWS
I
YQ
D
IQ
G
A
T
FL
L
NMA
AL
L
K
A
K
MT
TLN
S
L
NI
L
Q
E
F
A
SP
-
-
WL
ST
R
L
DS
I
I
YR
V
R
Q
G
D
HL
G
L
A
L
R
Q
CGY
Q
FPSR
E
A
A
N
F
L
S
L
L
Q
-
GD
G
A
TEL
I
S
NY
GQ
RWL
S
QTL
QR
VK
KR
A
NV
I
R
L
I
M
LIF
LV
M
SL
M
L
L
V
F
AI
MD
I
Q
SISDNSMGNF
fig|478004.5.peg.4954
Escherichia coli O157:H7 str. EC4401 (48-365/365)
MRDAWTDFGRK
W
H
P
F
A
E
-
-
LA
T
DCI
E
SL
RE
N
SGEN
S
L
E
Y
TL
SL
WVP
Q
EE
AA
V
ISAG
I
R
S
GSI
V
D
AL
Q
F
A
TTLTDA
K
E
Q
I
HQ
A
I
WQMA
IYP
VG
LL
IM
M
TG
TL
Y
VL
N
T
E
LIP
EL
S
KI
S
S
P
D
S
WS
GA
L
GF
L
YGL
S
V
FV
D
N
YG
AICAVLFAV
I
TG
LI
S
W
SL
PN
W
K
SPD
SV
R
TF
A
D
K
I
M
PWS
I
YQ
D
IQ
G
A
T
FL
L
NMA
AL
L
K
A
K
MT
TLN
S
L
NI
L
Q
E
F
A
SP
-
-
WL
ST
R
L
DS
I
I
YR
V
R
Q
G
D
HL
G
L
A
L
R
Q
CGY
Q
FPSR
E
A
A
N
F
L
S
L
L
Q
-
GD
G
A
TEL
I
S
NY
GQ
RWL
S
QTL
QR
VK
KR
A
NV
I
R
L
I
M
LIF
LV
M
SL
M
L
L
V
F
AI
MD
I
Q
SISDNSMGNF
fig|478005.5.peg.4410
Escherichia coli O157:H7 str. EC4486 (48-365/365)
MRDAWTDFGRK
W
H
P
F
A
E
-
-
LA
T
DCI
E
SL
RE
N
SGEN
S
L
E
Y
TL
SL
WVP
Q
EE
AA
V
ISAG
I
R
S
GSI
V
D
AL
Q
F
A
TTLTDA
K
E
Q
I
HQ
A
I
WQMA
IYP
VG
LL
IM
M
TG
TL
Y
VL
N
T
E
LIP
EL
S
KI
S
S
P
D
S
WS
GA
L
GF
L
YGL
S
V
FV
D
N
YG
AICAVLFAV
I
TG
LI
S
W
SL
PN
W
K
SPD
SV
R
TF
A
D
K
I
M
PWS
I
YQ
D
IQ
G
A
T
FL
L
NMA
AL
L
K
A
K
MT
TLN
S
L
NI
L
Q
E
F
A
SP
-
-
WL
ST
R
L
DS
I
I
YR
V
R
Q
G
D
HL
G
L
A
L
R
Q
CGY
Q
FPSR
E
A
A
N
F
L
S
L
L
Q
-
GD
G
A
TEL
I
S
NY
GQ
RWL
S
QTL
QR
VK
KR
A
NV
I
R
L
I
M
LIF
LV
M
SL
M
L
L
V
F
AI
MD
I
Q
SISDNSMGNF
fig|409438.11.peg.5037
Escherichia coli SE11 (48-365/365)
MRDAWTDFGRK
W
H
P
F
A
E
-
-
LA
T
DCI
E
SL
RE
N
SGEN
S
L
E
Y
TL
SL
WVP
Q
EE
AA
V
ISAG
I
R
S
GSI
V
D
AL
Q
F
A
TTLTDA
K
E
Q
I
HQ
A
I
WQMA
IYP
VG
LL
IM
M
TG
TL
Y
VL
N
T
E
LIP
EL
S
KI
S
S
P
D
S
WS
GA
L
GF
L
YGL
S
V
FV
D
N
YG
AICSVLFAV
I
TG
LI
S
W
SL
PN
W
K
SPD
SV
R
TF
A
D
K
I
M
PWS
I
YQ
D
IQ
G
A
T
FL
L
N
I
A
AL
L
K
A
K
MT
TLN
S
L
NI
L
Q
E
F
A
SP
-
-
WL
ST
R
L
DS
I
I
YR
V
R
Q
G
D
HL
G
L
A
L
R
Q
CGY
Q
FPSR
E
A
A
N
F
L
S
L
L
Q
-
GD
G
A
TEL
I
S
NY
GQ
RWL
S
QTL
QR
VK
KR
A
NV
I
R
L
I
M
LIF
LV
M
SL
M
L
L
V
F
AI
MD
I
Q
SISDNSMGNF
fig|656440.3.peg.4192
Escherichia coli TA206 (43-345/354)
I
R
E
V
Y
T
RG
G
QR
F
H
P
FG
V
-
-
LA
Q
DC
L
D
SL
SV
N
REG
N
L
L
P
D
VF
RR
W
FS
G
EE
AA
S
LA
V
G
M
R
A
GS
L
L
T
AL
D
SL
IRLIRS
L
Q
S
I
RS
V
I
AGAA
L
A
P
FG
A
I
LA
L
SG
I
L
T
LL
SV
Q
L
V
P
QF
V
RI
I
P
P
E
K
AR
GA
L
AI
T
YGL
A
D
FV
T
T
A
G
PWVLGMLIV
F
FL
L
AL
W
SL
PR
WT
G
--
RI
R
QF
F
D
H
L
PPWS
M
Y
R
L
MQ
SSV
FL
I
N
L
S
T
L
I
G
A
R
MT
FQD
AL
KT
L
SD
G
G
VP
-
-
WL
QE
R
L
IP
A
Q
HH
FS
N
G
AD
L
G
T
A
L
E
R
A
G
HN
FPS
Q
E
M
I
L
H
L
KA
L
S
A
GE
G
A
ELA
I
A
N
L
AD
W
WL
G
R
T
-
--
--
--
-
--
-
R
A
I
A
RGM
L
Y
L
SL
L
I
S
V
V
M
V
FG
CLG
I
MA
S
SM
fig|749527.3.peg.4670
Escherichia coli MS 21-1 (54-361/364)
D
VE
TDFG
K
K
K
G
Q
S
G
L
Y
F
LA
T
DCI
A
S
I
RS
S
---
G
Q
LS
P
A
L
KD
WVP
K
D
E
IA
LI
R
N
GE
E
RG
D
IA
E
A
M
F
Q
V
VKTAKG
R
Q
EM
IS
S
L
VSVC
L
YP
LI
LL
TL
C
VV
NMY
NV
HT
R
V
IP
MI
S
AF
A
P
E
E
R
WS
VQ
M
VI
L
AKS
S
E
L
VI
G
YG
LWLLAGLLL
L
AI
LIR
M
S
F
SL
Y
T
G
--
PR
R
RY
LD
R
IPPWSLYQT
FH
GVN
Y
LFN
IS
SML
Q
I
N
IP
LSH
AL
TR
I
EK
H
A
EH
N
R
WL
KS
RI
SA
IR
KN
VL
S
GQ
S
LA
L
AM
K
N
CGYDFPS
K
S
C
V
N
N
LLL
N
SE
RE
D
S
VAS
M
A
L
YADRWL
E
EAK
KN
V
R
KS
G
II
IT
A
IS
GLL
VF
L
FI
I
N
MV
S
AI
YG
IS
D
M
fig|749548.3.peg.5348
Escherichia coli MS 196-1 (54-361/364)
D
VE
TDFG
K
K
K
G
Q
S
G
L
Y
F
LA
T
DCI
A
S
I
RS
S
---
G
Q
LS
P
A
L
KD
WVP
K
D
E
IA
LI
R
N
GE
E
RG
D
IA
E
A
M
F
Q
V
VKTAKG
R
Q
EM
IS
S
L
VSVC
L
YP
LI
LL
TL
C
VV
NMY
NV
HT
R
V
IP
MI
S
AF
A
P
E
E
R
WS
VQ
M
VI
L
AKS
S
G
L
VI
G
YG
LWLLAGLLL
L
AI
LIR
M
S
F
SL
Y
T
G
--
PR
R
RY
LD
R
IPPWSLYQT
FH
GVN
Y
LFN
IS
SML
Q
I
N
IP
LSH
AL
TR
I
EK
H
A
EH
N
R
WL
KS
RI
SA
IR
KN
VL
S
GQ
S
LA
L
AM
K
N
CGYDFPS
K
S
C
V
N
N
LLL
N
SE
RE
D
S
VAS
M
A
L
YADRWL
E
EAK
KN
V
R
KS
G
II
IT
A
IS
GLL
VF
L
FI
I
N
MV
S
AI
YG
IS
D
M
fig|749550.3.peg.4113
Escherichia coli MS 200-1 (54-361/364)
D
VE
TDFG
K
K
K
G
Q
S
G
L
Y
F
LA
T
DCI
A
S
I
RS
S
---
G
Q
LS
P
A
L
KD
WVP
K
D
E
IA
LI
R
N
GE
E
RG
D
IA
E
A
M
F
Q
V
VKTAKG
R
Q
EM
IS
S
L
VSVC
L
YP
LI
LL
TL
C
VV
NMY
NV
HT
R
V
IP
MI
S
AF
A
P
E
E
R
WS
VQ
M
VI
L
AKS
S
G
L
VI
G
YG
LWLLAGLLL
L
AI
LIR
M
S
F
SL
Y
T
G
--
PR
R
RY
LD
R
IPPWSLYQT
FH
GVN
Y
LFN
IS
SML
Q
I
N
IP
LSH
AL
TR
I
EK
H
A
EH
N
R
WL
KS
RI
SA
IR
KN
VL
S
GQ
S
LA
L
AM
K
N
CGYDFPS
K
S
C
V
N
N
LLL
N
SE
RE
D
S
VAS
M
A
L
YADRWL
E
EAK
KN
V
R
KS
G
II
IT
A
IS
GLL
VF
L
FI
I
N
MV
S
AI
YG
IS
D
M
fig|478005.5.peg.4326
Escherichia coli O157:H7 str. EC4486 (54-361/364)
D
VE
TDFG
K
K
K
G
Q
S
G
L
Y
F
LA
T
DCI
A
S
I
RS
S
---
G
Q
LS
P
A
L
KD
WVP
K
D
E
IA
LI
R
N
GE
E
RG
D
IA
E
A
M
F
Q
V
VKTAKG
R
Q
EM
IS
S
L
VSVC
L
YP
LI
LL
TL
C
VV
NMY
NV
HT
R
V
IP
MI
S
AF
A
P
E
E
R
WS
VQ
M
VI
L
AKS
S
G
L
VI
G
YG
LWLLAGLLL
L
AI
LIR
M
S
F
SL
Y
T
G
--
PR
R
RY
LD
R
IPPWSLYQT
FH
GVN
Y
LFN
IS
SML
Q
I
N
IP
LSH
AL
TR
I
EK
H
A
EH
N
R
WL
KS
RI
SA
IR
KN
VL
S
GQ
S
LA
L
AM
K
N
CGYDFPS
K
S
C
V
N
N
LLL
N
SE
RE
D
S
VAS
M
A
L
YADRWL
E
EAK
KN
V
R
KS
G
II
IT
A
IS
GLL
VF
L
FI
I
N
MV
S
AI
YG
IS
D
M
fig|340184.3.peg.1324
Escherichia coli B7A (54-361/364)
D
VE
TDFG
K
K
K
G
Q
S
G
L
Y
F
LA
T
DCI
A
S
I
RS
S
---
G
Q
LS
P
A
L
KD
WVP
K
D
E
IA
LI
R
N
GE
E
RG
D
IA
E
A
M
F
Q
V
VKTAKG
R
Q
EM
IS
S
L
VSVC
L
YP
LI
LL
TL
C
VV
NMY
NV
HT
R
V
IP
MI
S
AF
A
P
E
E
R
WS
VQ
M
VI
L
AKS
S
E
L
VI
G
YG
LWLLAGLLL
L
AI
LIR
M
S
F
SL
YKG
--
PR
R
RY
LD
R
IPPWSLYQT
FH
GVN
Y
LFN
IS
SML
Q
I
N
IP
LSH
AL
TR
I
EK
H
A
EH
N
R
WL
KS
RI
SA
IR
KN
VL
S
GQ
S
LA
L
AM
K
N
S
GYDFPS
K
S
C
V
N
N
LLL
N
SE
RE
D
S
VAS
M
A
L
YADRWL
E
EAK
KS
V
R
KS
G
II
IT
A
IS
GLL
VF
L
FI
I
N
MV
S
AI
YG
IS
D
M
fig|340184.6.peg.1394
Escherichia coli B7A (54-361/364)
D
VE
TDFG
K
K
K
G
Q
S
G
L
Y
F
LA
T
DCI
A
S
I
RS
S
---
G
Q
LS
P
A
L
KD
WVP
K
D
E
IA
LI
R
N
GE
E
RG
D
IA
E
A
M
F
Q
V
VKTAKG
R
Q
EM
IS
S
L
VSVC
L
YP
LI
LL
TL
C
VV
NMY
NV
HT
R
V
IP
MI
S
AF
A
P
E
E
R
WS
VQ
M
VI
L
AKS
S
E
L
VI
G
YG
LWLLAGLLL
L
AI
LIR
M
S
F
SL
YKG
--
PR
R
RY
LD
R
IPPWSLYQT
FH
GVN
Y
LFN
IS
SML
Q
I
N
IP
LSH
AL
TR
I
EK
H
A
EH
N
R
WL
KS
RI
SA
IR
KN
VL
S
GQ
S
LA
L
AM
K
N
S
GYDFPS
K
S
C
V
N
N
LLL
N
SE
RE
D
S
VAS
M
A
L
YADRWL
E
EAK
KS
V
R
KS
G
II
IT
A
IS
GLL
VF
L
FI
I
N
MV
S
AI
YG
IS
D
M
fig|585397.6.peg.270
Escherichia coli ED1a (59-363/366)
TDFG
E
K
K
G
T
S
G
M
Y
F
LA
K
E
CI
D
S
I
KA
S
---
G
M
LS
G
TL
LT
WVP
P
EE
AT
LI
R
N
GE
E
RG
N
IA
D
AL
F
Q
V
ARTVKA
R
R
EM
TS
S
L
IAVC
L
YP
LL
LL
SL
C
VV
NMY
NA
HT
R
I
IP
IV
S
AF
AS
E
D
K
WS
FQ
M
KL
L
AGM
S
E
F
F
I
G
YG
FWLCGTIFA
L
TL
LIR
F
S
F
SR
Y
T
G
--
PG
R
RM
LD
K
A
PPWSLYQT
LH
GVN
Y
LF
SIS
SML
Q
I
N
IP
LSQ
AL
LR
M
EK
G
A
EK
N
K
WL
KE
RI
QA
IR
KH
VL
S
GQ
N
LA
T
AMR
N
S
GYDFPSR
I
C
I
N
K
LLL
N
SE
RE
D
S
VAT
M
A
L
YAD
Q
WL
E
EAK
KR
VK
RI
G
LI
IT
G
IS
GGF
VF
F
FIL
N
M
I
S
AI
YS
IS
D
M
fig|585397.9.peg.5373
Escherichia coli ED1a (59-363/366)
TDFG
E
K
K
G
T
S
G
M
Y
F
LA
K
E
CI
D
S
I
KA
S
---
G
M
LS
G
TL
LT
WVP
P
EE
AT
LI
R
N
GE
E
RG
N
IA
D
AL
F
Q
V
ARTVKA
R
R
EM
TS
S
L
IAVC
L
YP
LL
LL
SL
C
VV
NMY
NA
HT
R
I
IP
IV
S
AF
AS
E
D
K
WS
FQ
M
KL
L
AGM
S
E
F
F
I
G
YG
FWLCGTIFA
L
TL
LIR
F
S
F
SR
Y
T
G
--
PG
R
RM
LD
K
A
PPWSLYQT
LH
GVN
Y
LF
SIS
SML
Q
I
N
IP
LSQ
AL
LR
M
EK
G
A
EK
N
K
WL
KE
RI
QA
IR
KH
VL
S
GQ
N
LA
T
AMR
N
S
GYDFPSR
I
C
I
N
K
LLL
N
SE
RE
D
S
VAT
M
A
L
YAD
Q
WL
E
EAK
KR
VK
RI
G
LI
IT
G
IS
GGF
VF
F
FIL
N
M
I
S
AI
YS
IS
D
M
fig|585397.7.peg.3513
Escherichia coli ED1a (59-363/366)
TDFG
E
K
K
G
T
S
G
M
Y
F
LA
K
E
CI
A
S
I
KA
S
---
G
M
LS
G
A
L
FT
WVP
P
EE
AT
LI
R
N
GE
E
RG
N
IA
D
AL
F
Q
V
ARTVKA
R
R
EM
TS
S
L
IAVC
L
YP
LL
LL
SL
C
VV
NMY
NA
HT
R
I
IP
IV
S
AF
A
T
E
D
K
WS
FQ
M
KV
L
AGM
S
E
F
I
I
G
YG
LWLCGAIIA
L
TV
LIR
F
S
F
SR
Y
T
G
--
PG
R
RM
LD
R
V
PPWSLYQT
LH
GVN
Y
LF
SIS
SML
Q
I
N
IP
LSQ
AL
LR
M
EK
G
A
EK
N
K
WL
KE
RI
QA
IR
KH
VL
S
GQ
N
LA
T
AMR
N
S
GYDFPSR
V
C
I
N
K
LLL
N
SE
RE
D
N
VAA
M
A
V
YAD
Q
WL
E
EAK
KR
VK
RS
G
LI
IT
G
IS
GGF
VF
F
FIL
N
M
I
S
AI
YS
IS
D
M
fig|585397.9.peg.3509
Escherichia coli ED1a (59-363/366)
TDFG
E
K
K
G
T
S
G
M
Y
F
LA
K
E
CI
A
S
I
KA
S
---
G
M
LS
G
A
L
FT
WVP
P
EE
AT
LI
R
N
GE
E
RG
N
IA
D
AL
F
Q
V
ARTVKA
R
R
EM
TS
S
L
IAVC
L
YP
LL
LL
SL
C
VV
NMY
NA
HT
R
I
IP
IV
S
AF
A
T
E
D
K
WS
FQ
M
KV
L
AGM
S
E
F
I
I
G
YG
LWLCGAIIA
L
TV
LIR
F
S
F
SR
Y
T
G
--
PG
R
RM
LD
R
V
PPWSLYQT
LH
GVN
Y
LF
SIS
SML
Q
I
N
IP
LSQ
AL
LR
M
EK
G
A
EK
N
K
WL
KE
RI
QA
IR
KH
VL
S
GQ
N
LA
T
AMR
N
S
GYDFPSR
V
C
I
N
K
LLL
N
SE
RE
D
N
VAA
M
A
V
YAD
Q
WL
E
EAK
KR
VK
RS
G
LI
IT
G
IS
GGF
VF
F
FIL
N
M
I
S
AI
YS
IS
D
M
fig|562.373.peg.670
Escherichia coli 1125A (59-366/369)
D
VE
TD
Y
G
K
K
T
G
S
SA
T
Y
Y
IC
C
E
C
L
N
A
L
NN
T
---
G
A
I
S
S
A
L
KK
YIK
E
D
E
YQ
LIS
S
GE
I
RG
D
L
A
G
G
L
V
QA
IKIVRS
R
S
EM
TM
T
L
VMSM
IYP
SV
L
V
FG
C
LA
NMY
MV
H
D
T
I
T
P
VF
L
SL
A
P
K
E
R
W
T
SS
M
RL
L
TDT
S
G
F
L
I
E
N
G
TYILCFCIV
L
FF
LIR
Y
SL
AR
Y
T
G
--
PG
R
QY
LD
Y
IPPWSLY
K
T
FN
GV
S
FLFNMASML
S
I
D
IP
VAK
AL
ER
LEK
N
S
TQ
N
R
WL
LE
RI
KE
IR
RY
VL
L
GQ
S
LA
M
AM
K
S
CGYDFPS
K
L
C
I
N
K
LLL
H
SE
NA
D
N
ALM
M
S
NYAD
K
WL
E
EAK
GK
VK
ST
G
VW
IT
V
V
S
ALI
VF
A
FI
V
M
M
I
T
A
L
YD
V
S
NV
fig|562.375.peg.5433
Escherichia coli EC4100B (59-366/369)
D
VE
TD
Y
G
K
K
T
G
S
SA
T
Y
Y
IC
C
E
C
L
N
A
L
NN
T
---
G
A
I
S
S
A
L
KK
YIK
E
D
E
YQ
LIS
S
GE
I
RG
D
L
A
G
G
L
V
QA
IKIVRS
R
S
EM
TM
T
L
VMSM
IYP
SV
L
V
FG
C
LA
NMY
MV
H
D
T
I
T
P
VF
L
SL
A
P
K
E
R
W
T
SS
M
RL
L
TDT
S
G
F
L
I
E
N
G
TYILCFCIV
L
FF
LIR
Y
SL
AR
Y
T
G
--
PG
R
QY
LD
Y
IPPWSLY
K
T
FN
GV
S
FLFNMASML
S
I
D
IP
VAK
AL
ER
LEK
N
S
TQ
N
R
WL
LE
RI
KE
IR
RY
VL
L
GQ
S
LA
M
AM
K
S
CGYDFPS
K
L
C
I
N
K
LLL
H
SE
NA
D
N
ALM
M
S
NYAD
K
WL
E
EAK
GK
VK
ST
G
VW
IT
V
V
S
ALI
VF
A
FI
V
M
M
I
T
A
L
YD
V
S
NV
fig|749540.3.peg.2828
Escherichia coli MS 146-1 (59-366/369)
D
VE
TD
Y
G
K
K
T
G
S
SA
T
Y
Y
IC
C
E
C
L
N
A
L
NN
T
---
G
A
I
S
S
A
L
KK
YIK
E
D
E
YQ
LIS
S
GE
I
RG
D
L
A
G
G
L
V
QA
IKIVRS
R
S
EM
TM
T
L
VMSM
IYP
SV
L
V
FG
C
LA
NMY
MV
H
D
T
I
T
P
VF
L
SL
A
P
K
E
R
W
T
SS
M
RL
L
TDT
S
G
F
L
I
E
N
G
TYILCFCIV
L
FF
LIR
Y
SL
AR
Y
T
G
--
PG
R
QY
LD
Y
IPPWSLY
K
T
FN
GV
S
FLFNMASML
S
I
D
IP
VAK
AL
ER
LEK
N
S
TQ
N
R
WL
LE
RI
KE
IR
RY
VL
L
GQ
S
LA
M
AM
K
S
CGYDFPS
K
L
C
I
N
K
LLL
H
SE
NA
D
N
AFM
M
S
NYAD
K
WL
E
EAK
GK
VK
ST
G
VW
IT
V
V
S
ALI
VF
A
FI
V
M
M
I
T
A
L
YD
V
S
NV
fig|444454.5.peg.879
Escherichia coli O157:H7 str. EC4024 (59-366/369)
D
VE
TD
Y
G
K
K
T
G
S
SA
T
Y
Y
IC
C
E
C
L
N
A
L
NN
T
---
G
A
I
S
S
A
L
KK
YIK
E
D
E
YQ
LIS
S
GE
I
RG
D
L
A
G
G
L
V
QA
IKIVRS
R
S
EM
TM
T
L
VMSM
IYP
SV
L
V
FG
C
LA
NMY
MV
H
D
T
I
T
P
VF
L
SL
A
P
K
E
R
W
T
SS
M
RL
L
TDT
S
G
F
L
I
E
N
G
TYILCFCIV
L
FF
LIR
Y
SL
AR
Y
T
G
--
PG
R
QY
LD
Y
IPPWSLY
K
T
FN
GV
S
FLFNMASML
S
I
D
IP
VAK
AL
ER
LEK
N
S
TQ
N
R
WL
LE
RI
KE
IR
RY
VL
L
GQ
S
LA
M
AM
K
S
CGYDFPS
K
L
C
I
N
K
LLL
H
SE
NA
D
N
ALM
M
S
NYAD
K
WL
E
EAK
GK
VK
ST
G
VW
IT
V
V
S
ALI
VF
A
FI
V
M
M
I
T
A
L
YD
V
S
NV
fig|637388.3.peg.3475
Escherichia coli O157:H7 str. FRIK2000 (59-366/369)
D
VE
TD
Y
G
K
K
T
G
S
SA
T
Y
Y
IC
C
E
C
L
N
A
L
NN
T
---
G
A
I
S
S
A
L
KK
YIK
E
D
E
YQ
LIS
S
GE
I
RG
D
L
A
G
G
L
V
QA
IKIVRS
R
S
EM
TM
T
L
VMSM
IYP
SV
L
F
FG
C
LV
NMY
MV
H
D
T
I
T
P
VF
L
SL
A
P
K
E
R
W
T
TS
M
RL
L
TDT
S
G
F
L
I
E
N
G
TYILCFCIV
L
FF
LIR
Y
SL
AR
Y
T
G
--
PG
R
QY
LD
Y
IPPWSLY
K
T
FN
GV
S
FLFNMASML
S
I
D
IP
VAK
AL
ER
LEK
N
S
TQ
N
R
WL
LE
RI
KE
IR
RY
VL
L
GQ
S
LA
M
AM
K
S
CGYDFPS
K
L
C
I
N
K
LLL
H
SE
NA
D
N
ALM
M
S
NYAD
K
WL
E
EAK
GK
VK
ST
G
VW
IT
V
V
S
ALI
VF
A
FI
V
M
M
I
T
A
L
YD
V
S
NV
fig|656393.3.peg.30
Escherichia coli H299 (59-363/366)
TDFG
T
R
K
G
T
S
G
M
Y
F
LA
R
E
CI
A
SL
KA
S
---
G
M
LS
G
A
L
PT
WVP
P
EE
AA
LI
R
N
GE
E
RG
N
IA
E
AL
F
Q
V
AKTVKA
R
R
EM
VS
S
L
ITLC
L
YP
LL
LL
SL
C
VV
NMY
NA
HT
R
I
IP
IV
S
AF
A
P
E
E
K
WS
FQ
M
KV
L
AAM
S
E
L
VI
G
YG
LWLSGAIIT
L
AI
I
IR
F
SL
SR
Y
T
G
--
PG
R
RL
LD
R
L
PPWSLYQT
FH
GVN
Y
LF
SIS
SML
Q
I
N
IP
LSQ
AL
LR
I
EK
S
A
EH
N
K
WL
KE
RI
QA
IR
KN
VL
S
GQ
N
LA
T
AMR
N
S
D
YDFPS
K
I
C
I
N
K
LLL
N
SE
RE
D
S
VSA
M
N
T
YA
G
Q
WL
E
D
AK
KS
V
R
KS
G
LI
IT
G
IS
GGF
VF
F
FIL
N
M
I
S
AI
YS
IS
D
M
Consen1
Primary consensus
MRDawTDfGrK
g
sa
y
la
dCi
sl
n
---
g
ls
tL
wvp
eE
lIsaGe
rGsia
al
qa
r
em
al
iYP
Ll
c
nmY
ht
liP
s
as
d
Ws
m
L
S
fvi
yG
l
lIr
Sl
ykg
--
R
lD
ipPWSlYqt
GvnfLfnmasmL
i
ip
aL
lek
a
n
WL
Ri
Ir
Vl
GqhLa
Amr
cGYdFPSr
c
N
LlL
se
da
m
nYadrWL
eak
Vk
g
it
is
vf
fil
mv
Ai
issisDNSMGNf
Consen2
Secondary consensus
ve
y
h
fg
-
ic
e
l
ai
sgen
ie
a
yik
d
v
r
i
s
lv
gm
fv
k
q
i
l
v
m
tl
nd
t
l
sp
e
t
l
l
d
n
v
s
f
wtspd
a
m
i
kd
a
y
lsisal
a
mt
s
q
s
-
l
i
r
d
g
lk
s
q
k
a
s
q
-
g
i
l
gq
qtl
r
a
vr
vm
lv
sl
li
vq
g
l
Consensus 1
(when a gap)
Conservative difference
Consensus 2
(when a gap)
Nonconservative diff.
Other character