fig|1040638.4.peg.5754
Escherichia coli O104:H4 str. LB226692
MN
I
IAI
MGPH
GV
FY
K
D
EPI
K
EL
ES
AL
VA
Q
G
FQII
W
P
Q
N
S
V
DLLK
F
IE
H
N
P
RICGVIFDWD
E
Y
S
LDLC
S
D
I
N
QL
-------
NE
Y
LPLYAF
I
NT
H
ST
M
DVS
VQ
---
D
M
R
M
-----
A
L
W
FFEYALG
-
Q
AEDIA
I
R
MR
Q
Y
T
D
EY
LDN
I
T
PP
F
TKALF
T
YV
K
E
R
KYTFCTPGHMGGTA
Y
QKSPVG
C
LFYDFFG
G
NT
L
K
A
D
V
SISVTELGSLLDHTGPH
L
EAE
E
YIAR
T
FGA
EQ
SY
I
VTNGTSTSNKIVGMY
A
AP
S
GST
L
LIDRNCHKSL
A
HLLMM
N
DV
V
PV
W
LK
PTRNA
L
GILGGIP
RR
EF
T
RD
S
I
E
E
KV
A
A
T
T
-----
Q
AQWPVHAVITNSTYDGLLYNTD
W
IK
Q
TLDV
P
S
--
IHFDSAWVPYT
H
F
H
PIY
Q
GK
S
GMSGERV
----
A
GKVIFETQSTHK
M
LAALSQAS
L
IH
I
----
KG
EY
D
EE
A
FNEA
F
MMHTTTSP
S
Y
P
IVAS
V
ETAAAM
L
R
GN
P
GKRLIN
R
S
V
ERA
L
H
FRKE
V
Q
---
RLR
E
E
---
SDGWFFD
I
WQP
PQ
VD
E
--------------------
A
ECWP
V
A
PGE
Q
WHGF
--
N
D
A
D
A
D
HM
F
LDP
V
KVTILTPGM
D
E
Q
G
N
MSE
E
GIPAALVAK
F
LDE
R
GIVVEKTGPYNLLFLFSIGIDKTKA
MG
LLR
G
LT
E
FKR
S
YDLNLR
I
KNMLP
D
LY
A
EDPDFY
R
NMRIQDLAQ
G
IHKLI
RK
H
D
LP
G
LM
L
RAF
DT
LP
E
M
I
MTP
HQ
A
W
Q
RQ
I
K
G
E
VE
T
I
A
LE
Q
LVGR
V
S
ANMILPYPPGVPLLMPGEM
L
T
K
ESR
T
VL
D
FL
L
MLCS
V
G
Q
HYPGFETDIHGA
KQDE
DG
V
Y
R
V
R
VLKMAG
fig|6666666.5357.peg.182
Escherichia coli TY-2482
MN
I
IAI
MGPH
GV
FY
K
D
EPI
K
EL
ES
AL
VA
Q
G
FQII
W
P
Q
N
S
V
DLLK
F
IE
H
N
P
RICGVIFDWD
E
Y
S
LDLC
S
D
I
N
QL
-------
NE
Y
LPLYAF
I
NT
H
ST
M
DVS
VQ
---
D
M
R
M
-----
A
L
W
FFEYALG
-
Q
AEDIA
I
R
MR
Q
Y
T
D
EY
LDN
I
T
PP
F
TKALF
T
YV
K
E
R
KYTFCTPGHMGGTA
Y
QKSPVG
C
LFYDFFG
G
NT
L
K
A
D
V
SISVTELGSLLDHTGPH
L
EAE
E
YIAR
T
FGA
EQ
SY
I
VTNGTSTSNKIVGMY
A
AP
S
GST
L
LIDRNCHKSL
A
HLLMM
N
DV
V
PV
W
LK
PTRNA
L
GILGGIP
RR
EF
T
RD
S
I
E
E
KV
A
A
T
T
-----
Q
AQWPVHAVITNSTYDGLLYNTD
W
IK
Q
TLDV
P
S
--
IHFDSAWVPYT
H
F
H
PIY
Q
GK
S
GMSGERV
----
A
GKVIFETQSTHK
M
LAALSQAS
L
IH
I
----
KG
EY
D
EE
A
FNEA
F
MMHTTTSP
S
Y
P
IVAS
V
ETAAAM
L
R
GN
P
GKRLIN
R
S
V
ERA
L
H
FRKE
V
Q
---
RLR
E
E
---
SDGWFFD
I
WQP
PQ
VD
E
--------------------
A
ECWP
V
A
PGE
Q
WHGF
--
N
D
A
D
A
D
HM
F
LDP
V
KVTILTPGM
D
E
Q
G
N
MSE
E
GIPAALVAK
F
LDE
R
GIVVEKTGPYNLLFLFSIGIDKTKA
MG
LLR
G
LT
E
FKR
S
YDLNLR
I
KNMLP
D
LY
A
EDPDFY
R
NMRIQDLAQ
G
IHKLI
RK
H
D
LP
G
LM
L
RAF
DT
LP
E
M
I
MTP
HQ
A
W
Q
RQ
I
K
G
E
VE
T
I
A
LE
Q
LVGR
V
S
ANMILPYPPGVPLLMPGEM
L
T
K
ESR
T
VL
D
FL
L
MLCS
V
G
Q
HYPGFETDIHGA
KQDE
DG
V
Y
R
V
R
VLKMAG
fig|344610.3.peg.3920
Escherichia coli 53638
MN
I
IAI
MGPH
GV
FY
K
D
EPI
K
EL
ES
AL
VA
Q
G
FQII
W
P
Q
N
S
V
DLLK
F
IE
H
N
P
RICGVIFDWD
E
Y
S
LDLC
S
D
I
N
QL
-------
NE
Y
LPLYAF
I
NT
H
ST
M
DVS
VQ
---
D
M
R
M
-----
A
L
W
FFEYALG
-
Q
AEDIA
I
R
MR
Q
Y
T
D
EY
LDN
I
T
PP
F
TKALF
T
YV
K
E
R
KYTFCTPGHMGGTA
Y
QKSPVG
C
LFYDFFG
G
NT
L
K
A
D
V
SISVTELGSLLDHTGPH
L
EAE
E
YIAR
T
FGA
EQ
SY
I
VTNGTSTSNKIVGMY
A
AP
S
GST
L
LIDRNCHKSL
A
HLLMM
N
DV
V
PV
W
LK
PTRNA
L
GILGGIP
RR
EF
T
RD
S
I
E
E
KV
A
A
T
T
-----
Q
AQWPVHAVITNSTYDGLLYNTD
W
IK
Q
TLDV
P
S
--
IHFDSAWVPYT
H
F
H
PIY
Q
GK
S
GMSGERV
----
A
GKVIFETQSTHK
M
LAALSQAS
L
IH
I
----
KG
EY
D
EE
A
FNEA
F
MMHTTTSP
S
Y
P
IVAS
V
ETAAAM
L
R
GN
P
GKRLIN
R
S
V
ERA
L
H
FRKE
V
Q
---
RLR
E
E
---
SDGWFFD
I
WQP
PQ
VD
E
--------------------
A
ECWP
V
A
PGE
Q
WHGF
--
N
D
A
D
A
D
HM
F
LDP
V
KVTILTPGM
D
E
Q
G
N
MSE
E
GIPAALVAK
F
LDE
R
GIVVEKTGPYNLLFLFSIGIDKTKA
MG
LLR
G
LT
E
FKR
S
YDLNLR
I
KNMLP
D
LY
A
EDPDFY
R
NMRIQDLAQ
G
IHKLI
RK
H
D
LP
G
LM
L
RAF
DT
LP
E
M
I
MTP
HQ
A
W
Q
RQ
I
K
G
E
VE
T
I
A
LE
Q
LVGR
V
S
ANMILPYPPGVPLLMPGEM
L
T
K
ESR
T
VL
D
FL
L
MLCS
V
G
Q
HYPGFETDIHGA
KQDE
DG
V
Y
R
V
R
VLKMAG
fig|344610.7.peg.1492
Escherichia coli 53638
MN
I
IAI
MGPH
GV
FY
K
D
EPI
K
EL
ES
AL
VA
Q
G
FQII
W
P
Q
N
S
V
DLLK
F
IE
H
N
P
RICGVIFDWD
E
Y
S
LDLC
S
D
I
N
QL
-------
NE
Y
LPLYAF
I
NT
H
ST
M
DVS
VQ
---
D
M
R
M
-----
A
L
W
FFEYALG
-
Q
AEDIA
I
R
MR
Q
Y
T
D
EY
LDN
I
T
PP
F
TKALF
T
YV
K
E
R
KYTFCTPGHMGGTA
Y
QKSPVG
C
LFYDFFG
G
NT
L
K
A
D
V
SISVTELGSLLDHTGPH
L
EAE
E
YIAR
T
FGA
EQ
SY
I
VTNGTSTSNKIVGMY
A
AP
S
GST
L
LIDRNCHKSL
A
HLLMM
N
DV
V
PV
W
LK
PTRNA
L
GILGGIP
RR
EF
T
RD
S
I
E
E
KV
A
A
T
T
-----
Q
AQWPVHAVITNSTYDGLLYNTD
W
IK
Q
TLDV
P
S
--
IHFDSAWVPYT
H
F
H
PIY
Q
GK
S
GMSGERV
----
A
GKVIFETQSTHK
M
LAALSQAS
L
IH
I
----
KG
EY
D
EE
A
FNEA
F
MMHTTTSP
S
Y
P
IVAS
V
ETAAAM
L
R
GN
P
GKRLIN
R
S
V
ERA
L
H
FRKE
V
Q
---
RLR
E
E
---
SDGWFFD
I
WQP
PQ
VD
E
--------------------
A
ECWP
V
A
PGE
Q
WHGF
--
N
D
A
D
A
D
HM
F
LDP
V
KVTILTPGM
D
E
Q
G
N
MSE
E
GIPAALVAK
F
LDE
R
GIVVEKTGPYNLLFLFSIGIDKTKA
MG
LLR
G
LT
E
FKR
S
YDLNLR
I
KNMLP
D
LY
A
EDPDFY
R
NMRIQDLAQ
G
IHKLI
RK
H
D
LP
G
LM
L
RAF
DT
LP
E
M
I
MTP
HQ
A
W
Q
RQ
I
K
G
E
VE
T
I
A
LE
Q
LVGR
V
S
ANMILPYPPGVPLLMPGEM
L
T
K
ESR
T
VL
D
FL
L
MLCS
V
G
Q
HYPGFETDIHGA
KQDE
DG
V
Y
R
V
R
VLKMAG
fig|585055.6.peg.190
Escherichia coli 55989
MN
I
IAI
MGPH
GV
FY
K
D
EPI
K
EL
ES
AL
VA
Q
G
FQII
W
P
Q
N
S
V
DLLK
F
IE
H
N
P
RICGVIFDWD
E
Y
S
LDLC
S
D
I
N
QL
-------
NE
Y
LPLYAF
I
NT
H
ST
M
DVS
VQ
---
D
M
R
M
-----
A
L
W
FFEYALG
-
Q
AEDIA
I
R
MR
Q
Y
T
D
EY
LDN
I
T
PP
F
TKALF
T
YV
K
E
R
KYTFCTPGHMGGTA
Y
QKSPVG
C
LFYDFFG
G
NT
L
K
A
D
V
SISVTELGSLLDHTGPH
L
EAE
E
YIAR
T
FGA
EQ
SY
I
VTNGTSTSNKIVGMY
A
AP
S
GST
L
LIDRNCHKSL
A
HLLMM
N
DV
V
PV
W
LK
PTRNA
L
GILGGIP
RR
EF
T
RD
S
I
E
E
KV
A
A
T
T
-----
Q
AQWPVHAVITNSTYDGLLYNTD
W
IK
Q
TLDV
P
S
--
IHFDSAWVPYT
H
F
H
PIY
Q
GK
S
GMSGERV
----
A
GKVIFETQSTHK
M
LAALSQAS
L
IH
I
----
KG
EY
D
EE
A
FNEA
F
MMHTTTSP
S
Y
P
IVAS
V
ETAAAM
L
R
GN
P
GKRLIN
R
S
V
ERA
L
H
FRKE
V
Q
---
RLR
E
E
---
SDGWFFD
I
WQP
PQ
VD
E
--------------------
A
ECWP
V
A
PGE
Q
WHGF
--
N
D
A
D
A
D
HM
F
LDP
V
KVTILTPGM
D
E
Q
G
N
MSE
E
GIPAALVAK
F
LDE
R
GIVVEKTGPYNLLFLFSIGIDKTKA
MG
LLR
G
LT
E
FKR
S
YDLNLR
I
KNMLP
D
LY
A
EDPDFY
R
NMRIQDLAQ
G
IHKLI
RK
H
D
LP
G
LM
L
RAF
DT
LP
E
M
I
MTP
HQ
A
W
Q
RQ
I
K
G
E
VE
T
I
A
LE
Q
LVGR
V
S
ANMILPYPPGVPLLMPGEM
L
T
K
ESR
T
VL
D
FL
L
MLCS
V
G
Q
HYPGFETDIHGA
KQDE
DG
V
Y
R
V
R
VLKMAG
fig|585055.8.peg.190
Escherichia coli 55989
MN
I
IAI
MGPH
GV
FY
K
D
EPI
K
EL
ES
AL
VA
Q
G
FQII
W
P
Q
N
S
V
DLLK
F
IE
H
N
P
RICGVIFDWD
E
Y
S
LDLC
S
D
I
N
QL
-------
NE
Y
LPLYAF
I
NT
H
ST
M
DVS
VQ
---
D
M
R
M
-----
A
L
W
FFEYALG
-
Q
AEDIA
I
R
MR
Q
Y
T
D
EY
LDN
I
T
PP
F
TKALF
T
YV
K
E
R
KYTFCTPGHMGGTA
Y
QKSPVG
C
LFYDFFG
G
NT
L
K
A
D
V
SISVTELGSLLDHTGPH
L
EAE
E
YIAR
T
FGA
EQ
SY
I
VTNGTSTSNKIVGMY
A
AP
S
GST
L
LIDRNCHKSL
A
HLLMM
N
DV
V
PV
W
LK
PTRNA
L
GILGGIP
RR
EF
T
RD
S
I
E
E
KV
A
A
T
T
-----
Q
AQWPVHAVITNSTYDGLLYNTD
W
IK
Q
TLDV
P
S
--
IHFDSAWVPYT
H
F
H
PIY
Q
GK
S
GMSGERV
----
A
GKVIFETQSTHK
M
LAALSQAS
L
IH
I
----
KG
EY
D
EE
A
FNEA
F
MMHTTTSP
S
Y
P
IVAS
V
ETAAAM
L
R
GN
P
GKRLIN
R
S
V
ERA
L
H
FRKE
V
Q
---
RLR
E
E
---
SDGWFFD
I
WQP
PQ
VD
E
--------------------
A
ECWP
V
A
PGE
Q
WHGF
--
N
D
A
D
A
D
HM
F
LDP
V
KVTILTPGM
D
E
Q
G
N
MSE
E
GIPAALVAK
F
LDE
R
GIVVEKTGPYNLLFLFSIGIDKTKA
MG
LLR
G
LT
E
FKR
S
YDLNLR
I
KNMLP
D
LY
A
EDPDFY
R
NMRIQDLAQ
G
IHKLI
RK
H
D
LP
G
LM
L
RAF
DT
LP
E
M
I
MTP
HQ
A
W
Q
RQ
I
K
G
E
VE
T
I
A
LE
Q
LVGR
V
S
ANMILPYPPGVPLLMPGEM
L
T
K
ESR
T
VL
D
FL
L
MLCS
V
G
Q
HYPGFETDIHGA
KQDE
DG
V
Y
R
V
R
VLKMAG
fig|340184.3.peg.2132
Escherichia coli B7A
MN
I
IAI
MGPH
GV
FY
K
D
EPI
K
EL
ES
AL
VA
Q
G
FQII
W
P
Q
N
S
V
DLLK
F
IE
H
N
P
RICGVIFDWD
E
Y
S
LDLC
S
D
I
N
QL
-------
NE
Y
LPLYAF
I
NT
H
ST
M
DVS
VQ
---
D
M
R
M
-----
A
L
W
FFEYALG
-
Q
AEDIA
I
R
MR
Q
Y
T
D
EY
LDN
I
T
PP
F
TKALF
T
YV
K
E
R
KYTFCTPGHMGGTA
Y
QKSPVG
C
LFYDFFG
G
NT
L
K
A
D
V
SISVTELGSLLDHTGPH
L
EAE
E
YIAR
T
FGA
EQ
SY
I
VTNGTSTSNKIVGMY
A
AP
S
GST
L
LIDRNCHKSL
A
HLLMM
N
DV
V
PV
W
LK
PTRNA
L
GILGGIP
RR
EF
T
RD
S
I
E
E
KV
A
A
T
T
-----
Q
AQWPVHAVITNSTYDGLLYNTD
W
IK
Q
TLDV
P
S
--
IHFDSAWVPYT
H
F
H
PIY
Q
GK
S
GMSGERV
----
A
GKVIFETQSTHK
M
LAALSQAS
L
IH
I
----
KG
EY
D
EE
A
FNEA
F
MMHTTTSP
S
Y
P
IVAS
V
ETAAAM
L
R
GN
P
GKRLIN
R
S
V
ERA
L
H
FRKE
V
Q
---
RLR
E
E
---
SDGWFFD
I
WQP
PQ
VD
E
--------------------
A
ECWP
V
A
PGE
Q
WHGF
--
N
D
A
D
A
D
HM
F
LDP
V
KVTILTPGM
D
E
Q
G
N
MSE
E
GIPAALVAK
F
LDE
R
GIVVEKTGPYNLLFLFSIGIDKTKA
MG
LLR
G
LT
E
FKR
S
YDLNLR
I
KNMLP
D
LY
A
EDPDFY
R
NMRIQDLAQ
G
IHKLI
RK
H
D
LP
G
LM
L
RAF
DT
LP
E
M
I
MTP
HQ
A
W
Q
RQ
I
K
G
E
VE
T
I
A
LE
Q
LVGR
V
S
ANMILPYPPGVPLLMPGEM
L
T
K
ESR
T
VL
D
FL
L
MLCS
V
G
Q
HYPGFETDIHGA
KQDE
DG
V
Y
R
V
R
VLKMAG
fig|340184.6.peg.2237
Escherichia coli B7A
MN
I
IAI
MGPH
GV
FY
K
D
EPI
K
EL
ES
AL
VA
Q
G
FQII
W
P
Q
N
S
V
DLLK
F
IE
H
N
P
RICGVIFDWD
E
Y
S
LDLC
S
D
I
N
QL
-------
NE
Y
LPLYAF
I
NT
H
ST
M
DVS
VQ
---
D
M
R
M
-----
A
L
W
FFEYALG
-
Q
AEDIA
I
R
MR
Q
Y
T
D
EY
LDN
I
T
PP
F
TKALF
T
YV
K
E
R
KYTFCTPGHMGGTA
Y
QKSPVG
C
LFYDFFG
G
NT
L
K
A
D
V
SISVTELGSLLDHTGPH
L
EAE
E
YIAR
T
FGA
EQ
SY
I
VTNGTSTSNKIVGMY
A
AP
S
GST
L
LIDRNCHKSL
A
HLLMM
N
DV
V
PV
W
LK
PTRNA
L
GILGGIP
RR
EF
T
RD
S
I
E
E
KV
A
A
T
T
-----
Q
AQWPVHAVITNSTYDGLLYNTD
W
IK
Q
TLDV
P
S
--
IHFDSAWVPYT
H
F
H
PIY
Q
GK
S
GMSGERV
----
A
GKVIFETQSTHK
M
LAALSQAS
L
IH
I
----
KG
EY
D
EE
A
FNEA
F
MMHTTTSP
S
Y
P
IVAS
V
ETAAAM
L
R
GN
P
GKRLIN
R
S
V
ERA
L
H
FRKE
V
Q
---
RLR
E
E
---
SDGWFFD
I
WQP
PQ
VD
E
--------------------
A
ECWP
V
A
PGE
Q
WHGF
--
N
D
A
D
A
D
HM
F
LDP
V
KVTILTPGM
D
E
Q
G
N
MSE
E
GIPAALVAK
F
LDE
R
GIVVEKTGPYNLLFLFSIGIDKTKA
MG
LLR
G
LT
E
FKR
S
YDLNLR
I
KNMLP
D
LY
A
EDPDFY
R
NMRIQDLAQ
G
IHKLI
RK
H
D
LP
G
LM
L
RAF
DT
LP
E
M
I
MTP
HQ
A
W
Q
RQ
I
K
G
E
VE
T
I
A
LE
Q
LVGR
V
S
ANMILPYPPGVPLLMPGEM
L
T
K
ESR
T
VL
D
FL
L
MLCS
V
G
Q
HYPGFETDIHGA
KQDE
DG
V
Y
R
V
R
VLKMAG
fig|595496.3.peg.193
Escherichia coli BW2952
MN
I
IAI
MGPH
GV
FY
K
D
EPI
K
EL
ES
AL
VA
Q
G
FQII
W
P
Q
N
S
V
DLLK
F
IE
H
N
P
RICGVIFDWD
E
Y
S
LDLC
S
D
I
N
QL
-------
NE
Y
LPLYAF
I
NT
H
ST
M
DVS
VQ
---
D
M
R
M
-----
A
L
W
FFEYALG
-
Q
AEDIA
I
R
MR
Q
Y
T
D
EY
LDN
I
T
PP
F
TKALF
T
YV
K
E
R
KYTFCTPGHMGGTA
Y
QKSPVG
C
LFYDFFG
G
NT
L
K
A
D
V
SISVTELGSLLDHTGPH
L
EAE
E
YIAR
T
FGA
EQ
SY
I
VTNGTSTSNKIVGMY
A
AP
S
GST
L
LIDRNCHKSL
A
HLLMM
N
DV
V
PV
W
LK
PTRNA
L
GILGGIP
RR
EF
T
RD
S
I
E
E
KV
A
A
T
T
-----
Q
AQWPVHAVITNSTYDGLLYNTD
W
IK
Q
TLDV
P
S
--
IHFDSAWVPYT
H
F
H
PIY
Q
GK
S
GMSGERV
----
A
GKVIFETQSTHK
M
LAALSQAS
L
IH
I
----
KG
EY
D
EE
A
FNEA
F
MMHTTTSP
S
Y
P
IVAS
V
ETAAAM
L
R
GN
P
GKRLIN
R
S
V
ERA
L
H
FRKE
V
Q
---
RLR
E
E
---
SDGWFFD
I
WQP
PQ
VD
E
--------------------
A
ECWP
V
A
PGE
Q
WHGF
--
N
D
A
D
A
D
HM
F
LDP
V
KVTILTPGM
D
E
Q
G
N
MSE
E
GIPAALVAK
F
LDE
R
GIVVEKTGPYNLLFLFSIGIDKTKA
MG
LLR
G
LT
E
FKR
S
YDLNLR
I
KNMLP
D
LY
A
EDPDFY
R
NMRIQDLAQ
G
IHKLI
RK
H
D
LP
G
LM
L
RAF
DT
LP
E
M
I
MTP
HQ
A
W
Q
RQ
I
K
G
E
VE
T
I
A
LE
Q
LVGR
V
S
ANMILPYPPGVPLLMPGEM
L
T
K
ESR
T
VL
D
FL
L
MLCS
V
G
Q
HYPGFETDIHGA
KQDE
DG
V
Y
R
V
R
VLKMAG
fig|536056.3.peg.3610
Escherichia coli DH1
MN
I
IAI
MGPH
GV
FY
K
D
EPI
K
EL
ES
AL
VA
Q
G
FQII
W
P
Q
N
S
V
DLLK
F
IE
H
N
P
RICGVIFDWD
E
Y
S
LDLC
S
D
I
N
QL
-------
NE
Y
LPLYAF
I
NT
H
ST
M
DVS
VQ
---
D
M
R
M
-----
A
L
W
FFEYALG
-
Q
AEDIA
I
R
MR
Q
Y
T
D
EY
LDN
I
T
PP
F
TKALF
T
YV
K
E
R
KYTFCTPGHMGGTA
Y
QKSPVG
C
LFYDFFG
G
NT
L
K
A
D
V
SISVTELGSLLDHTGPH
L
EAE
E
YIAR
T
FGA
EQ
SY
I
VTNGTSTSNKIVGMY
A
AP
S
GST
L
LIDRNCHKSL
A
HLLMM
N
DV
V
PV
W
LK
PTRNA
L
GILGGIP
RR
EF
T
RD
S
I
E
E
KV
A
A
T
T
-----
Q
AQWPVHAVITNSTYDGLLYNTD
W
IK
Q
TLDV
P
S
--
IHFDSAWVPYT
H
F
H
PIY
Q
GK
S
GMSGERV
----
A
GKVIFETQSTHK
M
LAALSQAS
L
IH
I
----
KG
EY
D
EE
A
FNEA
F
MMHTTTSP
S
Y
P
IVAS
V
ETAAAM
L
R
GN
P
GKRLIN
R
S
V
ERA
L
H
FRKE
V
Q
---
RLR
E
E
---
SDGWFFD
I
WQP
PQ
VD
E
--------------------
A
ECWP
V
A
PGE
Q
WHGF
--
N
D
A
D
A
D
HM
F
LDP
V
KVTILTPGM
D
E
Q
G
N
MSE
E
GIPAALVAK
F
LDE
R
GIVVEKTGPYNLLFLFSIGIDKTKA
MG
LLR
G
LT
E
FKR
S
YDLNLR
I
KNMLP
D
LY
A
EDPDFY
R
NMRIQDLAQ
G
IHKLI
RK
H
D
LP
G
LM
L
RAF
DT
LP
E
M
I
MTP
HQ
A
W
Q
RQ
I
K
G
E
VE
T
I
A
LE
Q
LVGR
V
S
ANMILPYPPGVPLLMPGEM
L
T
K
ESR
T
VL
D
FL
L
MLCS
V
G
Q
HYPGFETDIHGA
KQDE
DG
V
Y
R
V
R
VLKMAG
fig|656408.3.peg.5150
Escherichia coli H591
MN
I
IAI
MGPH
GV
FY
K
D
EPI
K
EL
ES
AL
VA
Q
G
FQII
W
P
Q
N
S
V
DLLK
F
IE
H
N
P
RICGVIFDWD
E
Y
S
LDLC
S
D
I
N
QL
-------
NE
Y
LPLYAF
I
NT
H
ST
M
DVS
VQ
---
D
M
R
M
-----
A
L
W
FFEYALG
-
Q
AEDIA
I
R
MR
Q
Y
T
D
EY
LDN
I
T
PP
F
TKALF
T
YV
K
E
R
KYTFCTPGHMGGTA
Y
QKSPVG
C
LFYDFFG
G
NT
L
K
A
D
V
SISVTELGSLLDHTGPH
L
EAE
E
YIAR
T
FGA
EQ
SY
I
VTNGTSTSNKIVGMY
A
AP
S
GST
L
LIDRNCHKSL
A
HLLMM
N
DV
V
PV
W
LK
PTRNA
L
GILGGIP
RR
EF
T
RD
S
I
E
E
KV
A
A
T
T
-----
Q
AQWPVHAVITNSTYDGLLYNTD
W
IK
Q
TLDV
P
S
--
IHFDSAWVPYT
H
F
H
PIY
Q
GK
S
GMSGERV
----
A
GKVIFETQSTHK
M
LAALSQAS
L
IH
I
----
KG
EY
D
EE
A
FNEA
F
MMHTTTSP
S
Y
P
IVAS
V
ETAAAM
L
R
GN
P
GKRLIN
R
S
V
ERA
L
H
FRKE
V
Q
---
RLR
E
E
---
SDGWFFD
I
WQP
PQ
VD
E
--------------------
A
ECWP
V
A
PGE
Q
WHGF
--
N
D
A
D
A
D
HM
F
LDP
V
KVTILTPGM
D
E
Q
G
N
MSE
E
GIPAALVAK
F
LDE
R
GIVVEKTGPYNLLFLFSIGIDKTKA
MG
LLR
G
LT
E
FKR
S
YDLNLR
I
KNMLP
D
LY
A
EDPDFY
R
NMRIQDLAQ
G
IHKLI
RK
H
D
LP
G
LM
L
RAF
DT
LP
E
M
I
MTP
HQ
A
W
Q
RQ
I
K
G
E
VE
T
I
A
LE
Q
LVGR
V
S
ANMILPYPPGVPLLMPGEM
L
T
K
ESR
T
VL
D
FL
L
MLCS
V
G
Q
HYPGFETDIHGA
KQDE
DG
V
Y
R
V
R
VLKMAG
fig|656414.3.peg.315
Escherichia coli H736
MN
I
IAI
MGPH
GV
FY
K
D
EPI
K
EL
ES
AL
VA
Q
G
FQII
W
P
Q
N
S
V
DLLK
F
IE
H
N
P
RICGVIFDWD
E
Y
S
LDLC
S
D
I
N
QL
-------
NE
Y
LPLYAF
I
NT
H
ST
M
DVS
VQ
---
D
M
R
M
-----
A
L
W
FFEYALG
-
Q
AEDIA
I
R
MR
Q
Y
T
D
EY
LDN
I
T
PP
F
TKALF
T
YV
K
E
R
KYTFCTPGHMGGTA
Y
QKSPVG
C
LFYDFFG
G
NT
L
K
A
D
V
SISVTELGSLLDHTGPH
L
EAE
E
YIAR
T
FGA
EQ
SY
I
VTNGTSTSNKIVGMY
A
AP
S
GST
L
LIDRNCHKSL
A
HLLMM
N
DV
V
PV
W
LK
PTRNA
L
GILGGIP
RR
EF
T
RD
S
I
E
E
KV
A
A
T
T
-----
Q
AQWPVHAVITNSTYDGLLYNTD
W
IK
Q
TLDV
P
S
--
IHFDSAWVPYT
H
F
H
PIY
Q
GK
S
GMSGERV
----
A
GKVIFETQSTHK
M
LAALSQAS
L
IH
I
----
KG
EY
D
EE
A
FNEA
F
MMHTTTSP
S
Y
P
IVAS
V
ETAAAM
L
R
GN
P
GKRLIN
R
S
V
ERA
L
H
FRKE
V
Q
---
RLR
E
E
---
SDGWFFD
I
WQP
PQ
VD
E
--------------------
A
ECWP
V
A
PGE
Q
WHGF
--
N
D
A
D
A
D
HM
F
LDP
V
KVTILTPGM
D
E
Q
G
N
MSE
E
GIPAALVAK
F
LDE
R
GIVVEKTGPYNLLFLFSIGIDKTKA
MG
LLR
G
LT
E
FKR
S
YDLNLR
I
KNMLP
D
LY
A
EDPDFY
R
NMRIQDLAQ
G
IHKLI
RK
H
D
LP
G
LM
L
RAF
DT
LP
E
M
I
MTP
HQ
A
W
Q
RQ
I
K
G
E
VE
T
I
A
LE
Q
LVGR
V
S
ANMILPYPPGVPLLMPGEM
L
T
K
ESR
T
VL
D
FL
L
MLCS
V
G
Q
HYPGFETDIHGA
KQDE
DG
V
Y
R
V
R
VLKMAG
fig|331112.3.peg.185
Escherichia coli HS
MN
I
IAI
MGPH
GV
FY
K
D
EPI
K
EL
ES
AL
VA
Q
G
FQII
W
P
Q
N
S
V
DLLK
F
IE
H
N
P
RICGVIFDWD
E
Y
S
LDLC
S
D
I
N
QL
-------
NE
Y
LPLYAF
I
NT
H
ST
M
DVS
VQ
---
D
M
R
M
-----
A
L
W
FFEYALG
-
Q
AEDIA
I
R
MR
Q
Y
T
D
EY
LDN
I
T
PP
F
TKALF
T
YV
K
E
R
KYTFCTPGHMGGTA
Y
QKSPVG
C
LFYDFFG
G
NT
L
K
A
D
V
SISVTELGSLLDHTGPH
L
EAE
E
YIAR
T
FGA
EQ
SY
I
VTNGTSTSNKIVGMY
A
AP
S
GST
L
LIDRNCHKSL
A
HLLMM
N
DV
V
PV
W
LK
PTRNA
L
GILGGIP
RR
EF
T
RD
S
I
E
E
KV
A
A
T
T
-----
Q
AQWPVHAVITNSTYDGLLYNTD
W
IK
Q
TLDV
P
S
--
IHFDSAWVPYT
H
F
H
PIY
Q
GK
S
GMSGERV
----
A
GKVIFETQSTHK
M
LAALSQAS
L
IH
I
----
KG
EY
D
EE
A
FNEA
F
MMHTTTSP
S
Y
P
IVAS
V
ETAAAM
L
R
GN
P
GKRLIN
R
S
V
ERA
L
H
FRKE
V
Q
---
RLR
E
E
---
SDGWFFD
I
WQP
PQ
VD
E
--------------------
A
ECWP
V
A
PGE
Q
WHGF
--
N
D
A
D
A
D
HM
F
LDP
V
KVTILTPGM
D
E
Q
G
N
MSE
E
GIPAALVAK
F
LDE
R
GIVVEKTGPYNLLFLFSIGIDKTKA
MG
LLR
G
LT
E
FKR
S
YDLNLR
I
KNMLP
D
LY
A
EDPDFY
R
NMRIQDLAQ
G
IHKLI
RK
H
D
LP
G
LM
L
RAF
DT
LP
E
M
I
MTP
HQ
A
W
Q
RQ
I
K
G
E
VE
T
I
A
LE
Q
LVGR
V
S
ANMILPYPPGVPLLMPGEM
L
T
K
ESR
T
VL
D
FL
L
MLCS
V
G
Q
HYPGFETDIHGA
KQDE
DG
V
Y
R
V
R
VLKMAG
fig|331112.6.peg.192
Escherichia coli HS
MN
I
IAI
MGPH
GV
FY
K
D
EPI
K
EL
ES
AL
VA
Q
G
FQII
W
P
Q
N
S
V
DLLK
F
IE
H
N
P
RICGVIFDWD
E
Y
S
LDLC
S
D
I
N
QL
-------
NE
Y
LPLYAF
I
NT
H
ST
M
DVS
VQ
---
D
M
R
M
-----
A
L
W
FFEYALG
-
Q
AEDIA
I
R
MR
Q
Y
T
D
EY
LDN
I
T
PP
F
TKALF
T
YV
K
E
R
KYTFCTPGHMGGTA
Y
QKSPVG
C
LFYDFFG
G
NT
L
K
A
D
V
SISVTELGSLLDHTGPH
L
EAE
E
YIAR
T
FGA
EQ
SY
I
VTNGTSTSNKIVGMY
A
AP
S
GST
L
LIDRNCHKSL
A
HLLMM
N
DV
V
PV
W
LK
PTRNA
L
GILGGIP
RR
EF
T
RD
S
I
E
E
KV
A
A
T
T
-----
Q
AQWPVHAVITNSTYDGLLYNTD
W
IK
Q
TLDV
P
S
--
IHFDSAWVPYT
H
F
H
PIY
Q
GK
S
GMSGERV
----
A
GKVIFETQSTHK
M
LAALSQAS
L
IH
I
----
KG
EY
D
EE
A
FNEA
F
MMHTTTSP
S
Y
P
IVAS
V
ETAAAM
L
R
GN
P
GKRLIN
R
S
V
ERA
L
H
FRKE
V
Q
---
RLR
E
E
---
SDGWFFD
I
WQP
PQ
VD
E
--------------------
A
ECWP
V
A
PGE
Q
WHGF
--
N
D
A
D
A
D
HM
F
LDP
V
KVTILTPGM
D
E
Q
G
N
MSE
E
GIPAALVAK
F
LDE
R
GIVVEKTGPYNLLFLFSIGIDKTKA
MG
LLR
G
LT
E
FKR
S
YDLNLR
I
KNMLP
D
LY
A
EDPDFY
R
NMRIQDLAQ
G
IHKLI
RK
H
D
LP
G
LM
L
RAF
DT
LP
E
M
I
MTP
HQ
A
W
Q
RQ
I
K
G
E
VE
T
I
A
LE
Q
LVGR
V
S
ANMILPYPPGVPLLMPGEM
L
T
K
ESR
T
VL
D
FL
L
MLCS
V
G
Q
HYPGFETDIHGA
KQDE
DG
V
Y
R
V
R
VLKMAG
fig|585034.4.peg.191
Escherichia coli IAI1
MN
I
IAI
MGPH
GV
FY
K
D
EPI
K
EL
ES
AL
VA
Q
G
FQII
W
P
Q
N
S
V
DLLK
F
IE
H
N
P
RICGVIFDWD
E
Y
S
LDLC
S
D
I
N
QL
-------
NE
Y
LPLYAF
I
NT
H
ST
M
DVS
VQ
---
D
M
R
M
-----
A
L
W
FFEYALG
-
Q
AEDIA
I
R
MR
Q
Y
T
D
EY
LDN
I
T
PP
F
TKALF
T
YV
K
E
R
KYTFCTPGHMGGTA
Y
QKSPVG
C
LFYDFFG
G
NT
L
K
A
D
V
SISVTELGSLLDHTGPH
L
EAE
E
YIAR
T
FGA
EQ
SY
I
VTNGTSTSNKIVGMY
A
AP
S
GST
L
LIDRNCHKSL
A
HLLMM
N
DV
V
PV
W
LK
PTRNA
L
GILGGIP
RR
EF
T
RD
S
I
E
E
KV
A
A
T
T
-----
Q
AQWPVHAVITNSTYDGLLYNTD
W
IK
Q
TLDV
P
S
--
IHFDSAWVPYT
H
F
H
PIY
Q
GK
S
GMSGERV
----
A
GKVIFETQSTHK
M
LAALSQAS
L
IH
I
----
KG
EY
D
EE
A
FNEA
F
MMHTTTSP
S
Y
P
IVAS
V
ETAAAM
L
R
GN
P
GKRLIN
R
S
V
ERA
L
H
FRKE
V
Q
---
RLR
E
E
---
SDGWFFD
I
WQP
PQ
VD
E
--------------------
A
ECWP
V
A
PGE
Q
WHGF
--
N
D
A
D
A
D
HM
F
LDP
V
KVTILTPGM
D
E
Q
G
N
MSE
E
GIPAALVAK
F
LDE
R
GIVVEKTGPYNLLFLFSIGIDKTKA
MG
LLR
G
LT
E
FKR
S
YDLNLR
I
KNMLP
D
LY
A
EDPDFY
R
NMRIQDLAQ
G
IHKLI
RK
H
D
LP
G
LM
L
RAF
DT
LP
E
M
I
MTP
HQ
A
W
Q
RQ
I
K
G
E
VE
T
I
A
LE
Q
LVGR
V
S
ANMILPYPPGVPLLMPGEM
L
T
K
ESR
T
VL
D
FL
L
MLCS
V
G
Q
HYPGFETDIHGA
KQDE
DG
V
Y
R
V
R
VLKMAG
fig|585034.5.peg.191
Escherichia coli IAI1
MN
I
IAI
MGPH
GV
FY
K
D
EPI
K
EL
ES
AL
VA
Q
G
FQII
W
P
Q
N
S
V
DLLK
F
IE
H
N
P
RICGVIFDWD
E
Y
S
LDLC
S
D
I
N
QL
-------
NE
Y
LPLYAF
I
NT
H
ST
M
DVS
VQ
---
D
M
R
M
-----
A
L
W
FFEYALG
-
Q
AEDIA
I
R
MR
Q
Y
T
D
EY
LDN
I
T
PP
F
TKALF
T
YV
K
E
R
KYTFCTPGHMGGTA
Y
QKSPVG
C
LFYDFFG
G
NT
L
K
A
D
V
SISVTELGSLLDHTGPH
L
EAE
E
YIAR
T
FGA
EQ
SY
I
VTNGTSTSNKIVGMY
A
AP
S
GST
L
LIDRNCHKSL
A
HLLMM
N
DV
V
PV
W
LK
PTRNA
L
GILGGIP
RR
EF
T
RD
S
I
E
E
KV
A
A
T
T
-----
Q
AQWPVHAVITNSTYDGLLYNTD
W
IK
Q
TLDV
P
S
--
IHFDSAWVPYT
H
F
H
PIY
Q
GK
S
GMSGERV
----
A
GKVIFETQSTHK
M
LAALSQAS
L
IH
I
----
KG
EY
D
EE
A
FNEA
F
MMHTTTSP
S
Y
P
IVAS
V
ETAAAM
L
R
GN
P
GKRLIN
R
S
V
ERA
L
H
FRKE
V
Q
---
RLR
E
E
---
SDGWFFD
I
WQP
PQ
VD
E
--------------------
A
ECWP
V
A
PGE
Q
WHGF
--
N
D
A
D
A
D
HM
F
LDP
V
KVTILTPGM
D
E
Q
G
N
MSE
E
GIPAALVAK
F
LDE
R
GIVVEKTGPYNLLFLFSIGIDKTKA
MG
LLR
G
LT
E
FKR
S
YDLNLR
I
KNMLP
D
LY
A
EDPDFY
R
NMRIQDLAQ
G
IHKLI
RK
H
D
LP
G
LM
L
RAF
DT
LP
E
M
I
MTP
HQ
A
W
Q
RQ
I
K
G
E
VE
T
I
A
LE
Q
LVGR
V
S
ANMILPYPPGVPLLMPGEM
L
T
K
ESR
T
VL
D
FL
L
MLCS
V
G
Q
HYPGFETDIHGA
KQDE
DG
V
Y
R
V
R
VLKMAG
fig|83333.1.peg.186
Escherichia coli K12
MN
I
IAI
MGPH
GV
FY
K
D
EPI
K
EL
ES
AL
VA
Q
G
FQII
W
P
Q
N
S
V
DLLK
F
IE
H
N
P
RICGVIFDWD
E
Y
S
LDLC
S
D
I
N
QL
-------
NE
Y
LPLYAF
I
NT
H
ST
M
DVS
VQ
---
D
M
R
M
-----
A
L
W
FFEYALG
-
Q
AEDIA
I
R
MR
Q
Y
T
D
EY
LDN
I
T
PP
F
TKALF
T
YV
K
E
R
KYTFCTPGHMGGTA
Y
QKSPVG
C
LFYDFFG
G
NT
L
K
A
D
V
SISVTELGSLLDHTGPH
L
EAE
E
YIAR
T
FGA
EQ
SY
I
VTNGTSTSNKIVGMY
A
AP
S
GST
L
LIDRNCHKSL
A
HLLMM
N
DV
V
PV
W
LK
PTRNA
L
GILGGIP
RR
EF
T
RD
S
I
E
E
KV
A
A
T
T
-----
Q
AQWPVHAVITNSTYDGLLYNTD
W
IK
Q
TLDV
P
S
--
IHFDSAWVPYT
H
F
H
PIY
Q
GK
S
GMSGERV
----
A
GKVIFETQSTHK
M
LAALSQAS
L
IH
I
----
KG
EY
D
EE
A
FNEA
F
MMHTTTSP
S
Y
P
IVAS
V
ETAAAM
L
R
GN
P
GKRLIN
R
S
V
ERA
L
H
FRKE
V
Q
---
RLR
E
E
---
SDGWFFD
I
WQP
PQ
VD
E
--------------------
A
ECWP
V
A
PGE
Q
WHGF
--
N
D
A
D
A
D
HM
F
LDP
V
KVTILTPGM
D
E
Q
G
N
MSE
E
GIPAALVAK
F
LDE
R
GIVVEKTGPYNLLFLFSIGIDKTKA
MG
LLR
G
LT
E
FKR
S
YDLNLR
I
KNMLP
D
LY
A
EDPDFY
R
NMRIQDLAQ
G
IHKLI
RK
H
D
LP
G
LM
L
RAF
DT
LP
E
M
I
MTP
HQ
A
W
Q
RQ
I
K
G
E
VE
T
I
A
LE
Q
LVGR
V
S
ANMILPYPPGVPLLMPGEM
L
T
K
ESR
T
VL
D
FL
L
MLCS
V
G
Q
HYPGFETDIHGA
KQDE
DG
V
Y
R
V
R
VLKMAG
fig|679207.4.peg.1235
Escherichia coli MS 107-1
MN
I
IAI
MGPH
GV
FY
K
D
EPI
K
EL
ES
AL
VA
Q
G
FQII
W
P
Q
N
S
V
DLLK
F
IE
H
N
P
RICGVIFDWD
E
Y
S
LDLC
S
D
I
N
QL
-------
NE
Y
LPLYAF
I
NT
H
ST
M
DVS
VQ
---
D
M
R
M
-----
A
L
W
FFEYALG
-
Q
AEDIA
I
R
MR
Q
Y
T
D
EY
LDN
I
T
PP
F
TKALF
T
YV
K
E
R
KYTFCTPGHMGGTA
Y
QKSPVG
C
LFYDFFG
G
NT
L
K
A
D
V
SISVTELGSLLDHTGPH
L
EAE
E
YIAR
T
FGA
EQ
SY
I
VTNGTSTSNKIVGMY
A
AP
S
GST
L
LIDRNCHKSL
A
HLLMM
N
DV
V
PV
W
LK
PTRNA
L
GILGGIP
RR
EF
T
RD
S
I
E
E
KV
A
A
T
T
-----
Q
AQWPVHAVITNSTYDGLLYNTD
W
IK
Q
TLDV
P
S
--
IHFDSAWVPYT
H
F
H
PIY
Q
GK
S
GMSGERV
----
A
GKVIFETQSTHK
M
LAALSQAS
L
IH
I
----
KG
EY
D
EE
A
FNEA
F
MMHTTTSP
S
Y
P
IVAS
V
ETAAAM
L
R
GN
P
GKRLIN
R
S
V
ERA
L
H
FRKE
V
Q
---
RLR
E
E
---
SDGWFFD
I
WQP
PQ
VD
E
--------------------
A
ECWP
V
A
PGE
Q
WHGF
--
N
D
A
D
A
D
HM
F
LDP
V
KVTILTPGM
D
E
Q
G
N
MSE
E
GIPAALVAK
F
LDE
R
GIVVEKTGPYNLLFLFSIGIDKTKA
MG
LLR
G
LT
E
FKR
S
YDLNLR
I
KNMLP
D
LY
A
EDPDFY
R
NMRIQDLAQ
G
IHKLI
RK
H
D
LP
G
LM
L
RAF
DT
LP
E
M
I
MTP
HQ
A
W
Q
RQ
I
K
G
E
VE
T
I
A
LE
Q
LVGR
V
S
ANMILPYPPGVPLLMPGEM
L
T
K
ESR
T
VL
D
FL
L
MLCS
V
G
Q
HYPGFETDIHGA
KQDE
DG
V
Y
R
V
R
VLKMAG
fig|749538.3.peg.3014
Escherichia coli MS 116-1
MN
I
IAI
MGPH
GV
FY
K
D
EPI
K
EL
ES
AL
VA
Q
G
FQII
W
P
Q
N
S
V
DLLK
F
IE
H
N
P
RICGVIFDWD
E
Y
S
LDLC
S
D
I
N
QL
-------
NE
Y
LPLYAF
I
NT
H
ST
M
DVS
VQ
---
D
M
R
M
-----
A
L
W
FFEYALG
-
Q
AEDIA
I
R
MR
Q
Y
T
D
EY
LDN
I
T
PP
F
TKALF
T
YV
K
E
R
KYTFCTPGHMGGTA
Y
QKSPVG
C
LFYDFFG
G
NT
L
K
A
D
V
SISVTELGSLLDHTGPH
L
EAE
E
YIAR
T
FGA
EQ
SY
I
VTNGTSTSNKIVGMY
A
AP
S
GST
L
LIDRNCHKSL
A
HLLMM
N
DV
V
PV
W
LK
PTRNA
L
GILGGIP
RR
EF
T
RD
S
I
E
E
KV
A
A
T
T
-----
Q
AQWPVHAVITNSTYDGLLYNTD
W
IK
Q
TLDV
P
S
--
IHFDSAWVPYT
H
F
H
PIY
Q
GK
S
GMSGERV
----
A
GKVIFETQSTHK
M
LAALSQAS
L
IH
I
----
KG
EY
D
EE
A
FNEA
F
MMHTTTSP
S
Y
P
IVAS
V
ETAAAM
L
R
GN
P
GKRLIN
R
S
V
ERA
L
H
FRKE
V
Q
---
RLR
E
E
---
SDGWFFD
I
WQP
PQ
VD
E
--------------------
A
ECWP
V
A
PGE
Q
WHGF
--
N
D
A
D
A
D
HM
F
LDP
V
KVTILTPGM
D
E
Q
G
N
MSE
E
GIPAALVAK
F
LDE
R
GIVVEKTGPYNLLFLFSIGIDKTKA
MG
LLR
G
LT
E
FKR
S
YDLNLR
I
KNMLP
D
LY
A
EDPDFY
R
NMRIQDLAQ
G
IHKLI
RK
H
D
LP
G
LM
L
RAF
DT
LP
E
M
I
MTP
HQ
A
W
Q
RQ
I
K
G
E
VE
T
I
A
LE
Q
LVGR
V
S
ANMILPYPPGVPLLMPGEM
L
T
K
ESR
T
VL
D
FL
L
MLCS
V
G
Q
HYPGFETDIHGA
KQDE
DG
V
Y
R
V
R
VLKMAG
fig|679206.4.peg.3848
Escherichia coli MS 119-7
MN
I
IAI
MGPH
GV
FY
K
D
EPI
K
EL
ES
AL
VA
Q
G
FQII
W
P
Q
N
S
V
DLLK
F
IE
H
N
P
RICGVIFDWD
E
Y
S
LDLC
S
D
I
N
QL
-------
NE
Y
LPLYAF
I
NT
H
ST
M
DVS
VQ
---
D
M
R
M
-----
A
L
W
FFEYALG
-
Q
AEDIA
I
R
MR
Q
Y
T
D
EY
LDN
I
T
PP
F
TKALF
T
YV
K
E
R
KYTFCTPGHMGGTA
Y
QKSPVG
C
LFYDFFG
G
NT
L
K
A
D
V
SISVTELGSLLDHTGPH
L
EAE
E
YIAR
T
FGA
EQ
SY
I
VTNGTSTSNKIVGMY
A
AP
S
GST
L
LIDRNCHKSL
A
HLLMM
N
DV
V
PV
W
LK
PTRNA
L
GILGGIP
RR
EF
T
RD
S
I
E
E
KV
A
A
T
T
-----
Q
AQWPVHAVITNSTYDGLLYNTD
W
IK
Q
TLDV
P
S
--
IHFDSAWVPYT
H
F
H
PIY
Q
GK
S
GMSGERV
----
A
GKVIFETQSTHK
M
LAALSQAS
L
IH
I
----
KG
EY
D
EE
A
FNEA
F
MMHTTTSP
S
Y
P
IVAS
V
ETAAAM
L
R
GN
P
GKRLIN
R
S
V
ERA
L
H
FRKE
V
Q
---
RLR
E
E
---
SDGWFFD
I
WQP
PQ
VD
E
--------------------
A
ECWP
V
A
PGE
Q
WHGF
--
N
D
A
D
A
D
HM
F
LDP
V
KVTILTPGM
D
E
Q
G
N
MSE
E
GIPAALVAK
F
LDE
R
GIVVEKTGPYNLLFLFSIGIDKTKA
MG
LLR
G
LT
E
FKR
S
YDLNLR
I
KNMLP
D
LY
A
EDPDFY
R
NMRIQDLAQ
G
IHKLI
RK
H
D
LP
G
LM
L
RAF
DT
LP
E
M
I
MTP
HQ
A
W
Q
RQ
I
K
G
E
VE
T
I
A
LE
Q
LVGR
V
S
ANMILPYPPGVPLLMPGEM
L
T
K
ESR
T
VL
D
FL
L
MLCS
V
G
Q
HYPGFETDIHGA
KQDE
DG
V
Y
R
V
R
VLKMAG
fig|679205.4.peg.3797
Escherichia coli MS 124-1
MN
I
IAI
MGPH
GV
FY
K
D
EPI
K
EL
ES
AL
VA
Q
G
FQII
W
P
Q
N
S
V
DLLK
F
IE
H
N
P
RICGVIFDWD
E
Y
S
LDLC
S
D
I
N
QL
-------
NE
Y
LPLYAF
I
NT
H
ST
M
DVS
VQ
---
D
M
R
M
-----
A
L
W
FFEYALG
-
Q
AEDIA
I
R
MR
Q
Y
T
D
EY
LDN
I
T
PP
F
TKALF
T
YV
K
E
R
KYTFCTPGHMGGTA
Y
QKSPVG
C
LFYDFFG
G
NT
L
K
A
D
V
SISVTELGSLLDHTGPH
L
EAE
E
YIAR
T
FGA
EQ
SY
I
VTNGTSTSNKIVGMY
A
AP
S
GST
L
LIDRNCHKSL
A
HLLMM
N
DV
V
PV
W
LK
PTRNA
L
GILGGIP
RR
EF
T
RD
S
I
E
E
KV
A
A
T
T
-----
Q
AQWPVHAVITNSTYDGLLYNTD
W
IK
Q
TLDV
P
S
--
IHFDSAWVPYT
H
F
H
PIY
Q
GK
S
GMSGERV
----
A
GKVIFETQSTHK
M
LAALSQAS
L
IH
I
----
KG
EY
D
EE
A
FNEA
F
MMHTTTSP
S
Y
P
IVAS
V
ETAAAM
L
R
GN
P
GKRLIN
R
S
V
ERA
L
H
FRKE
V
Q
---
RLR
E
E
---
SDGWFFD
I
WQP
PQ
VD
E
--------------------
A
ECWP
V
A
PGE
Q
WHGF
--
N
D
A
D
A
D
HM
F
LDP
V
KVTILTPGM
D
E
Q
G
N
MSE
E
GIPAALVAK
F
LDE
R
GIVVEKTGPYNLLFLFSIGIDKTKA
MG
LLR
G
LT
E
FKR
S
YDLNLR
I
KNMLP
D
LY
A
EDPDFY
R
NMRIQDLAQ
G
IHKLI
RK
H
D
LP
G
LM
L
RAF
DT
LP
E
M
I
MTP
HQ
A
W
Q
RQ
I
K
G
E
VE
T
I
A
LE
Q
LVGR
V
S
ANMILPYPPGVPLLMPGEM
L
T
K
ESR
T
VL
D
FL
L
MLCS
V
G
Q
HYPGFETDIHGA
KQDE
DG
V
Y
R
V
R
VLKMAG
fig|679204.3.peg.3488
Escherichia coli MS 145-7
MN
I
IAI
MGPH
GV
FY
K
D
EPI
K
EL
ES
AL
VA
Q
G
FQII
W
P
Q
N
S
V
DLLK
F
IE
H
N
P
RICGVIFDWD
E
Y
S
LDLC
S
D
I
N
QL
-------
NE
Y
LPLYAF
I
NT
H
ST
M
DVS
VQ
---
D
M
R
M
-----
A
L
W
FFEYALG
-
Q
AEDIA
I
R
MR
Q
Y
T
D
EY
LDN
I
T
PP
F
TKALF
T
YV
K
E
R
KYTFCTPGHMGGTA
Y
QKSPVG
C
LFYDFFG
G
NT
L
K
A
D
V
SISVTELGSLLDHTGPH
L
EAE
E
YIAR
T
FGA
EQ
SY
I
VTNGTSTSNKIVGMY
A
AP
S
GST
L
LIDRNCHKSL
A
HLLMM
N
DV
V
PV
W
LK
PTRNA
L
GILGGIP
RR
EF
T
RD
S
I
E
E
KV
A
A
T
T
-----
Q
AQWPVHAVITNSTYDGLLYNTD
W
IK
Q
TLDV
P
S
--
IHFDSAWVPYT
H
F
H
PIY
Q
GK
S
GMSGERV
----
A
GKVIFETQSTHK
M
LAALSQAS
L
IH
I
----
KG
EY
D
EE
A
FNEA
F
MMHTTTSP
S
Y
P
IVAS
V
ETAAAM
L
R
GN
P
GKRLIN
R
S
V
ERA
L
H
FRKE
V
Q
---
RLR
E
E
---
SDGWFFD
I
WQP
PQ
VD
E
--------------------
A
ECWP
V
A
PGE
Q
WHGF
--
N
D
A
D
A
D
HM
F
LDP
V
KVTILTPGM
D
E
Q
G
N
MSE
E
GIPAALVAK
F
LDE
R
GIVVEKTGPYNLLFLFSIGIDKTKA
MG
LLR
G
LT
E
FKR
S
YDLNLR
I
KNMLP
D
LY
A
EDPDFY
R
NMRIQDLAQ
G
IHKLI
RK
H
D
LP
G
LM
L
RAF
DT
LP
E
M
I
MTP
HQ
A
W
Q
RQ
I
K
G
E
VE
T
I
A
LE
Q
LVGR
V
S
ANMILPYPPGVPLLMPGEM
L
T
K
ESR
T
VL
D
FL
L
MLCS
V
G
Q
HYPGFETDIHGA
KQDE
DG
V
Y
R
V
R
VLKMAG
fig|749540.3.peg.2969
Escherichia coli MS 146-1
MN
I
IAI
MGPH
GV
FY
K
D
EPI
K
EL
ES
AL
VA
Q
G
FQII
W
P
Q
N
S
V
DLLK
F
IE
H
N
P
RICGVIFDWD
E
Y
S
LDLC
S
D
I
N
QL
-------
NE
Y
LPLYAF
I
NT
H
ST
M
DVS
VQ
---
D
M
R
M
-----
A
L
W
FFEYALG
-
Q
AEDIA
I
R
MR
Q
Y
T
D
EY
LDN
I
T
PP
F
TKALF
T
YV
K
E
R
KYTFCTPGHMGGTA
Y
QKSPVG
C
LFYDFFG
G
NT
L
K
A
D
V
SISVTELGSLLDHTGPH
L
EAE
E
YIAR
T
FGA
EQ
SY
I
VTNGTSTSNKIVGMY
A
AP
S
GST
L
LIDRNCHKSL
A
HLLMM
N
DV
V
PV
W
LK
PTRNA
L
GILGGIP
RR
EF
T
RD
S
I
E
E
KV
A
A
T
T
-----
Q
AQWPVHAVITNSTYDGLLYNTD
W
IK
Q
TLDV
P
S
--
IHFDSAWVPYT
H
F
H
PIY
Q
GK
S
GMSGERV
----
A
GKVIFETQSTHK
M
LAALSQAS
L
IH
I
----
KG
EY
D
EE
A
FNEA
F
MMHTTTSP
S
Y
P
IVAS
V
ETAAAM
L
R
GN
P
GKRLIN
R
S
V
ERA
L
H
FRKE
V
Q
---
RLR
E
E
---
SDGWFFD
I
WQP
PQ
VD
E
--------------------
A
ECWP
V
A
PGE
Q
WHGF
--
N
D
A
D
A
D
HM
F
LDP
V
KVTILTPGM
D
E
Q
G
N
MSE
E
GIPAALVAK
F
LDE
R
GIVVEKTGPYNLLFLFSIGIDKTKA
MG
LLR
G
LT
E
FKR
S
YDLNLR
I
KNMLP
D
LY
A
EDPDFY
R
NMRIQDLAQ
G
IHKLI
RK
H
D
LP
G
LM
L
RAF
DT
LP
E
M
I
MTP
HQ
A
W
Q
RQ
I
K
G
E
VE
T
I
A
LE
Q
LVGR
V
S
ANMILPYPPGVPLLMPGEM
L
T
K
ESR
T
VL
D
FL
L
MLCS
V
G
Q
HYPGFETDIHGA
KQDE
DG
V
Y
R
V
R
VLKMAG
fig|749544.3.peg.1839
Escherichia coli MS 175-1
MN
I
IAI
MGPH
GV
FY
K
D
EPI
K
EL
ES
AL
VA
Q
G
FQII
W
P
Q
N
S
V
DLLK
F
IE
H
N
P
RICGVIFDWD
E
Y
S
LDLC
S
D
I
N
QL
-------
NE
Y
LPLYAF
I
NT
H
ST
M
DVS
VQ
---
D
M
R
M
-----
A
L
W
FFEYALG
-
Q
AEDIA
I
R
MR
Q
Y
T
D
EY
LDN
I
T
PP
F
TKALF
T
YV
K
E
R
KYTFCTPGHMGGTA
Y
QKSPVG
C
LFYDFFG
G
NT
L
K
A
D
V
SISVTELGSLLDHTGPH
L
EAE
E
YIAR
T
FGA
EQ
SY
I
VTNGTSTSNKIVGMY
A
AP
S
GST
L
LIDRNCHKSL
A
HLLMM
N
DV
V
PV
W
LK
PTRNA
L
GILGGIP
RR
EF
T
RD
S
I
E
E
KV
A
A
T
T
-----
Q
AQWPVHAVITNSTYDGLLYNTD
W
IK
Q
TLDV
P
S
--
IHFDSAWVPYT
H
F
H
PIY
Q
GK
S
GMSGERV
----
A
GKVIFETQSTHK
M
LAALSQAS
L
IH
I
----
KG
EY
D
EE
A
FNEA
F
MMHTTTSP
S
Y
P
IVAS
V
ETAAAM
L
R
GN
P
GKRLIN
R
S
V
ERA
L
H
FRKE
V
Q
---
RLR
E
E
---
SDGWFFD
I
WQP
PQ
VD
E
--------------------
A
ECWP
V
A
PGE
Q
WHGF
--
N
D
A
D
A
D
HM
F
LDP
V
KVTILTPGM
D
E
Q
G
N
MSE
E
GIPAALVAK
F
LDE
R
GIVVEKTGPYNLLFLFSIGIDKTKA
MG
LLR
G
LT
E
FKR
S
YDLNLR
I
KNMLP
D
LY
A
EDPDFY
R
NMRIQDLAQ
G
IHKLI
RK
H
D
LP
G
LM
L
RAF
DT
LP
E
M
I
MTP
HQ
A
W
Q
RQ
I
K
G
E
VE
T
I
A
LE
Q
LVGR
V
S
ANMILPYPPGVPLLMPGEM
L
T
K
ESR
T
VL
D
FL
L
MLCS
V
G
Q
HYPGFETDIHGA
KQDE
DG
V
Y
R
V
R
VLKMAG
fig|749548.3.peg.4221
Escherichia coli MS 196-1
MN
I
IAI
MGPH
GV
FY
K
D
EPI
K
EL
ES
AL
VA
Q
G
FQII
W
P
Q
N
S
V
DLLK
F
IE
H
N
P
RICGVIFDWD
E
Y
S
LDLC
S
D
I
N
QL
-------
NE
Y
LPLYAF
I
NT
H
ST
M
DVS
VQ
---
D
M
R
M
-----
A
L
W
FFEYALG
-
Q
AEDIA
I
R
MR
Q
Y
T
D
EY
LDN
I
T
PP
F
TKALF
T
YV
K
E
R
KYTFCTPGHMGGTA
Y
QKSPVG
C
LFYDFFG
G
NT
L
K
A
D
V
SISVTELGSLLDHTGPH
L
EAE
E
YIAR
T
FGA
EQ
SY
I
VTNGTSTSNKIVGMY
A
AP
S
GST
L
LIDRNCHKSL
A
HLLMM
N
DV
V
PV
W
LK
PTRNA
L
GILGGIP
RR
EF
T
RD
S
I
E
E
KV
A
A
T
T
-----
Q
AQWPVHAVITNSTYDGLLYNTD
W
IK
Q
TLDV
P
S
--
IHFDSAWVPYT
H
F
H
PIY
Q
GK
S
GMSGERV
----
A
GKVIFETQSTHK
M
LAALSQAS
L
IH
I
----
KG
EY
D
EE
A
FNEA
F
MMHTTTSP
S
Y
P
IVAS
V
ETAAAM
L
R
GN
P
GKRLIN
R
S
V
ERA
L
H
FRKE
V
Q
---
RLR
E
E
---
SDGWFFD
I
WQP
PQ
VD
E
--------------------
A
ECWP
V
A
PGE
Q
WHGF
--
N
D
A
D
A
D
HM
F
LDP
V
KVTILTPGM
D
E
Q
G
N
MSE
E
GIPAALVAK
F
LDE
R
GIVVEKTGPYNLLFLFSIGIDKTKA
MG
LLR
G
LT
E
FKR
S
YDLNLR
I
KNMLP
D
LY
A
EDPDFY
R
NMRIQDLAQ
G
IHKLI
RK
H
D
LP
G
LM
L
RAF
DT
LP
E
M
I
MTP
HQ
A
W
Q
RQ
I
K
G
E
VE
T
I
A
LE
Q
LVGR
V
S
ANMILPYPPGVPLLMPGEM
L
T
K
ESR
T
VL
D
FL
L
MLCS
V
G
Q
HYPGFETDIHGA
KQDE
DG
V
Y
R
V
R
VLKMAG
fig|749531.3.peg.4423
Escherichia coli MS 69-1
MN
I
IAI
MGPH
GV
FY
K
D
EPI
K
EL
ES
AL
VA
Q
G
FQII
W
P
Q
N
S
V
DLLK
F
IE
H
N
P
RICGVIFDWD
E
Y
S
LDLC
S
D
I
N
QL
-------
NE
Y
LPLYAF
I
NT
H
ST
M
DVS
VQ
---
D
M
R
M
-----
A
L
W
FFEYALG
-
Q
AEDIA
I
R
MR
Q
Y
T
D
EY
LDN
I
T
PP
F
TKALF
T
YV
K
E
R
KYTFCTPGHMGGTA
Y
QKSPVG
C
LFYDFFG
G
NT
L
K
A
D
V
SISVTELGSLLDHTGPH
L
EAE
E
YIAR
T
FGA
EQ
SY
I
VTNGTSTSNKIVGMY
A
AP
S
GST
L
LIDRNCHKSL
A
HLLMM
N
DV
V
PV
W
LK
PTRNA
L
GILGGIP
RR
EF
T
RD
S
I
E
E
KV
A
A
T
T
-----
Q
AQWPVHAVITNSTYDGLLYNTD
W
IK
Q
TLDV
P
S
--
IHFDSAWVPYT
H
F
H
PIY
Q
GK
S
GMSGERV
----
A
GKVIFETQSTHK
M
LAALSQAS
L
IH
I
----
KG
EY
D
EE
A
FNEA
F
MMHTTTSP
S
Y
P
IVAS
V
ETAAAM
L
R
GN
P
GKRLIN
R
S
V
ERA
L
H
FRKE
V
Q
---
RLR
E
E
---
SDGWFFD
I
WQP
PQ
VD
E
--------------------
A
ECWP
V
A
PGE
Q
WHGF
--
N
D
A
D
A
D
HM
F
LDP
V
KVTILTPGM
D
E
Q
G
N
MSE
E
GIPAALVAK
F
LDE
R
GIVVEKTGPYNLLFLFSIGIDKTKA
MG
LLR
G
LT
E
FKR
S
YDLNLR
I
KNMLP
D
LY
A
EDPDFY
R
NMRIQDLAQ
G
IHKLI
RK
H
D
LP
G
LM
L
RAF
DT
LP
E
M
I
MTP
HQ
A
W
Q
RQ
I
K
G
E
VE
T
I
A
LE
Q
LVGR
V
S
ANMILPYPPGVPLLMPGEM
L
T
K
ESR
T
VL
D
FL
L
MLCS
V
G
Q
HYPGFETDIHGA
KQDE
DG
V
Y
R
V
R
VLKMAG
fig|749533.3.peg.206
Escherichia coli MS 84-1
MN
I
IAI
MGPH
GV
FY
K
D
EPI
K
EL
ES
AL
VA
Q
G
FQII
W
P
Q
N
S
V
DLLK
F
IE
H
N
P
RICGVIFDWD
E
Y
S
LDLC
S
D
I
N
QL
-------
NE
Y
LPLYAF
I
NT
H
ST
M
DVS
VQ
---
D
M
R
M
-----
A
L
W
FFEYALG
-
Q
AEDIA
I
R
MR
Q
Y
T
D
EY
LDN
I
T
PP
F
TKALF
T
YV
K
E
R
KYTFCTPGHMGGTA
Y
QKSPVG
C
LFYDFFG
G
NT
L
K
A
D
V
SISVTELGSLLDHTGPH
L
EAE
E
YIAR
T
FGA
EQ
SY
I
VTNGTSTSNKIVGMY
A
AP
S
GST
L
LIDRNCHKSL
A
HLLMM
N
DV
V
PV
W
LK
PTRNA
L
GILGGIP
RR
EF
T
RD
S
I
E
E
KV
A
A
T
T
-----
Q
AQWPVHAVITNSTYDGLLYNTD
W
IK
Q
TLDV
P
S
--
IHFDSAWVPYT
H
F
H
PIY
Q
GK
S
GMSGERV
----
A
GKVIFETQSTHK
M
LAALSQAS
L
IH
I
----
KG
EY
D
EE
A
FNEA
F
MMHTTTSP
S
Y
P
IVAS
V
ETAAAM
L
R
GN
P
GKRLIN
R
S
V
ERA
L
H
FRKE
V
Q
---
RLR
E
E
---
SDGWFFD
I
WQP
PQ
VD
E
--------------------
A
ECWP
V
A
PGE
Q
WHGF
--
N
D
A
D
A
D
HM
F
LDP
V
KVTILTPGM
D
E
Q
G
N
MSE
E
GIPAALVAK
F
LDE
R
GIVVEKTGPYNLLFLFSIGIDKTKA
MG
LLR
G
LT
E
FKR
S
YDLNLR
I
KNMLP
D
LY
A
EDPDFY
R
NMRIQDLAQ
G
IHKLI
RK
H
D
LP
G
LM
L
RAF
DT
LP
E
M
I
MTP
HQ
A
W
Q
RQ
I
K
G
E
VE
T
I
A
LE
Q
LVGR
V
S
ANMILPYPPGVPLLMPGEM
L
T
K
ESR
T
VL
D
FL
L
MLCS
V
G
Q
HYPGFETDIHGA
KQDE
DG
V
Y
R
V
R
VLKMAG
fig|585396.4.peg.193
Escherichia coli O111:H- str. 11128
MN
I
IAI
MGPH
GV
FY
K
D
EPI
K
EL
ES
AL
VA
Q
G
FQII
W
P
Q
N
S
V
DLLK
F
IE
H
N
P
RICGVIFDWD
E
Y
S
LDLC
S
D
I
N
QL
-------
NE
Y
LPLYAF
I
NT
H
ST
M
DVS
VQ
---
D
M
R
M
-----
A
L
W
FFEYALG
-
Q
AEDIA
I
R
MR
Q
Y
T
D
EY
LDN
I
T
PP
F
TKALF
T
YV
K
E
R
KYTFCTPGHMGGTA
Y
QKSPVG
C
LFYDFFG
G
NT
L
K
A
D
V
SISVTELGSLLDHTGPH
L
EAE
E
YIAR
T
FGA
EQ
SY
I
VTNGTSTSNKIVGMY
A
AP
S
GST
L
LIDRNCHKSL
A
HLLMM
N
DV
V
PV
W
LK
PTRNA
L
GILGGIP
RR
EF
T
RD
S
I
E
E
KV
A
A
T
T
-----
Q
AQWPVHAVITNSTYDGLLYNTD
W
IK
Q
TLDV
P
S
--
IHFDSAWVPYT
H
F
H
PIY
Q
GK
S
GMSGERV
----
A
GKVIFETQSTHK
M
LAALSQAS
L
IH
I
----
KG
EY
D
EE
A
FNEA
F
MMHTTTSP
S
Y
P
IVAS
V
ETAAAM
L
R
GN
P
GKRLIN
R
S
V
ERA
L
H
FRKE
V
Q
---
RLR
E
E
---
SDGWFFD
I
WQP
PQ
VD
E
--------------------
A
ECWP
V
A
PGE
Q
WHGF
--
N
D
A
D
A
D
HM
F
LDP
V
KVTILTPGM
D
E
Q
G
N
MSE
E
GIPAALVAK
F
LDE
R
GIVVEKTGPYNLLFLFSIGIDKTKA
MG
LLR
G
LT
E
FKR
S
YDLNLR
I
KNMLP
D
LY
A
EDPDFY
R
NMRIQDLAQ
G
IHKLI
RK
H
D
LP
G
LM
L
RAF
DT
LP
E
M
I
MTP
HQ
A
W
Q
RQ
I
K
G
E
VE
T
I
A
LE
Q
LVGR
V
S
ANMILPYPPGVPLLMPGEM
L
T
K
ESR
T
VL
D
FL
L
MLCS
V
G
Q
HYPGFETDIHGA
KQDE
DG
V
Y
R
V
R
VLKMAG
fig|409438.11.peg.307
Escherichia coli SE11
MN
I
IAI
MGPH
GV
FY
K
D
EPI
K
EL
ES
AL
VA
Q
G
FQII
W
P
Q
N
S
V
DLLK
F
IE
H
N
P
RICGVIFDWD
E
Y
S
LDLC
S
D
I
N
QL
-------
NE
Y
LPLYAF
I
NT
H
ST
M
DVS
VQ
---
D
M
R
M
-----
A
L
W
FFEYALG
-
Q
AEDIA
I
R
MR
Q
Y
T
D
EY
LDN
I
T
PP
F
TKALF
T
YV
K
E
R
KYTFCTPGHMGGTA
Y
QKSPVG
C
LFYDFFG
G
NT
L
K
A
D
V
SISVTELGSLLDHTGPH
L
EAE
E
YIAR
T
FGA
EQ
SY
I
VTNGTSTSNKIVGMY
A
AP
S
GST
L
LIDRNCHKSL
A
HLLMM
N
DV
V
PV
W
LK
PTRNA
L
GILGGIP
RR
EF
T
RD
S
I
E
E
KV
A
A
T
T
-----
Q
AQWPVHAVITNSTYDGLLYNTD
W
IK
Q
TLDV
P
S
--
IHFDSAWVPYT
H
F
H
PIY
Q
GK
S
GMSGERV
----
A
GKVIFETQSTHK
M
LAALSQAS
L
IH
I
----
KG
EY
D
EE
A
FNEA
F
MMHTTTSP
S
Y
P
IVAS
V
ETAAAM
L
R
GN
P
GKRLIN
R
S
V
ERA
L
H
FRKE
V
Q
---
RLR
E
E
---
SDGWFFD
I
WQP
PQ
VD
E
--------------------
A
ECWP
V
A
PGE
Q
WHGF
--
N
D
A
D
A
D
HM
F
LDP
V
KVTILTPGM
D
E
Q
G
N
MSE
E
GIPAALVAK
F
LDE
R
GIVVEKTGPYNLLFLFSIGIDKTKA
MG
LLR
G
LT
E
FKR
S
YDLNLR
I
KNMLP
D
LY
A
EDPDFY
R
NMRIQDLAQ
G
IHKLI
RK
H
D
LP
G
LM
L
RAF
DT
LP
E
M
I
MTP
HQ
A
W
Q
RQ
I
K
G
E
VE
T
I
A
LE
Q
LVGR
V
S
ANMILPYPPGVPLLMPGEM
L
T
K
ESR
T
VL
D
FL
L
MLCS
V
G
Q
HYPGFETDIHGA
KQDE
DG
V
Y
R
V
R
VLKMAG
fig|656443.3.peg.331
Escherichia coli TA271
MN
I
IAI
MGPH
GV
FY
K
D
EPI
K
EL
ES
AL
VA
Q
G
FQII
W
P
Q
N
S
V
DLLK
F
IE
H
N
P
RICGVIFDWD
E
Y
S
LDLC
S
D
I
N
QL
-------
NE
Y
LPLYAF
I
NT
H
ST
M
DVS
VQ
---
D
M
R
M
-----
A
L
W
FFEYALG
-
Q
AEDIA
I
R
MR
Q
Y
T
D
EY
LDN
I
T
PP
F
TKALF
T
YV
K
E
R
KYTFCTPGHMGGTA
Y
QKSPVG
C
LFYDFFG
G
NT
L
K
A
D
V
SISVTELGSLLDHTGPH
L
EAE
E
YIAR
T
FGA
EQ
SY
I
VTNGTSTSNKIVGMY
A
AP
S
GST
L
LIDRNCHKSL
A
HLLMM
N
DV
V
PV
W
LK
PTRNA
L
GILGGIP
RR
EF
T
RD
S
I
E
E
KV
A
A
T
T
-----
Q
AQWPVHAVITNSTYDGLLYNTD
W
IK
Q
TLDV
P
S
--
IHFDSAWVPYT
H
F
H
PIY
Q
GK
S
GMSGERV
----
A
GKVIFETQSTHK
M
LAALSQAS
L
IH
I
----
KG
EY
D
EE
A
FNEA
F
MMHTTTSP
S
Y
P
IVAS
V
ETAAAM
L
R
GN
P
GKRLIN
R
S
V
ERA
L
H
FRKE
V
Q
---
RLR
E
E
---
SDGWFFD
I
WQP
PQ
VD
E
--------------------
A
ECWP
V
A
PGE
Q
WHGF
--
N
D
A
D
A
D
HM
F
LDP
V
KVTILTPGM
D
E
Q
G
N
MSE
E
GIPAALVAK
F
LDE
R
GIVVEKTGPYNLLFLFSIGIDKTKA
MG
LLR
G
LT
E
FKR
S
YDLNLR
I
KNMLP
D
LY
A
EDPDFY
R
NMRIQDLAQ
G
IHKLI
RK
H
D
LP
G
LM
L
RAF
DT
LP
E
M
I
MTP
HQ
A
W
Q
RQ
I
K
G
E
VE
T
I
A
LE
Q
LVGR
V
S
ANMILPYPPGVPLLMPGEM
L
T
K
ESR
T
VL
D
FL
L
MLCS
V
G
Q
HYPGFETDIHGA
KQDE
DG
V
Y
R
V
R
VLKMAG
fig|316407.3.peg.182
Escherichia coli W3110
MN
I
IAI
MGPH
GV
FY
K
D
EPI
K
EL
ES
AL
VA
Q
G
FQII
W
P
Q
N
S
V
DLLK
F
IE
H
N
P
RICGVIFDWD
E
Y
S
LDLC
S
D
I
N
QL
-------
NE
Y
LPLYAF
I
NT
H
ST
M
DVS
VQ
---
D
M
R
M
-----
A
L
W
FFEYALG
-
Q
AEDIA
I
R
MR
Q
Y
T
D
EY
LDN
I
T
PP
F
TKALF
T
YV
K
E
R
KYTFCTPGHMGGTA
Y
QKSPVG
C
LFYDFFG
G
NT
L
K
A
D
V
SISVTELGSLLDHTGPH
L
EAE
E
YIAR
T
FGA
EQ
SY
I
VTNGTSTSNKIVGMY
A
AP
S
GST
L
LIDRNCHKSL
A
HLLMM
N
DV
V
PV
W
LK
PTRNA
L
GILGGIP
RR
EF
T
RD
S
I
E
E
KV
A
A
T
T
-----
Q
AQWPVHAVITNSTYDGLLYNTD
W
IK
Q
TLDV
P
S
--
IHFDSAWVPYT
H
F
H
PIY
Q
GK
S
GMSGERV
----
A
GKVIFETQSTHK
M
LAALSQAS
L
IH
I
----
KG
EY
D
EE
A
FNEA
F
MMHTTTSP
S
Y
P
IVAS
V
ETAAAM
L
R
GN
P
GKRLIN
R
S
V
ERA
L
H
FRKE
V
Q
---
RLR
E
E
---
SDGWFFD
I
WQP
PQ
VD
E
--------------------
A
ECWP
V
A
PGE
Q
WHGF
--
N
D
A
D
A
D
HM
F
LDP
V
KVTILTPGM
D
E
Q
G
N
MSE
E
GIPAALVAK
F
LDE
R
GIVVEKTGPYNLLFLFSIGIDKTKA
MG
LLR
G
LT
E
FKR
S
YDLNLR
I
KNMLP
D
LY
A
EDPDFY
R
NMRIQDLAQ
G
IHKLI
RK
H
D
LP
G
LM
L
RAF
DT
LP
E
M
I
MTP
HQ
A
W
Q
RQ
I
K
G
E
VE
T
I
A
LE
Q
LVGR
V
S
ANMILPYPPGVPLLMPGEM
L
T
K
ESR
T
VL
D
FL
L
MLCS
V
G
Q
HYPGFETDIHGA
KQDE
DG
V
Y
R
V
R
VLKMAG
fig|316385.5.peg.167
Escherichia coli str. K-12 substr. DH10B
MN
I
IAI
MGPH
GV
FY
K
D
EPI
K
EL
ES
AL
VA
Q
G
FQII
W
P
Q
N
S
V
DLLK
F
IE
H
N
P
RICGVIFDWD
E
Y
S
LDLC
S
D
I
N
QL
-------
NE
Y
LPLYAF
I
NT
H
ST
M
DVS
VQ
---
D
M
R
M
-----
A
L
W
FFEYALG
-
Q
AEDIA
I
R
MR
Q
Y
T
D
EY
LDN
I
T
PP
F
TKALF
T
YV
K
E
R
KYTFCTPGHMGGTA
Y
QKSPVG
C
LFYDFFG
G
NT
L
K
A
D
V
SISVTELGSLLDHTGPH
L
EAE
E
YIAR
T
FGA
EQ
SY
I
VTNGTSTSNKIVGMY
A
AP
S
GST
L
LIDRNCHKSL
A
HLLMM
N
DV
V
PV
W
LK
PTRNA
L
GILGGIP
RR
EF
T
RD
S
I
E
E
KV
A
A
T
T
-----
Q
AQWPVHAVITNSTYDGLLYNTD
W
IK
Q
TLDV
P
S
--
IHFDSAWVPYT
H
F
H
PIY
Q
GK
S
GMSGERV
----
A
GKVIFETQSTHK
M
LAALSQAS
L
IH
I
----
KG
EY
D
EE
A
FNEA
F
MMHTTTSP
S
Y
P
IVAS
V
ETAAAM
L
R
GN
P
GKRLIN
R
S
V
ERA
L
H
FRKE
V
Q
---
RLR
E
E
---
SDGWFFD
I
WQP
PQ
VD
E
--------------------
A
ECWP
V
A
PGE
Q
WHGF
--
N
D
A
D
A
D
HM
F
LDP
V
KVTILTPGM
D
E
Q
G
N
MSE
E
GIPAALVAK
F
LDE
R
GIVVEKTGPYNLLFLFSIGIDKTKA
MG
LLR
G
LT
E
FKR
S
YDLNLR
I
KNMLP
D
LY
A
EDPDFY
R
NMRIQDLAQ
G
IHKLI
RK
H
D
LP
G
LM
L
RAF
DT
LP
E
M
I
MTP
HQ
A
W
Q
RQ
I
K
G
E
VE
T
I
A
LE
Q
LVGR
V
S
ANMILPYPPGVPLLMPGEM
L
T
K
ESR
T
VL
D
FL
L
MLCS
V
G
Q
HYPGFETDIHGA
KQDE
DG
V
Y
R
V
R
VLKMAG
fig|316385.7.peg.170
Escherichia coli str. K-12 substr. DH10B
MN
I
IAI
MGPH
GV
FY
K
D
EPI
K
EL
ES
AL
VA
Q
G
FQII
W
P
Q
N
S
V
DLLK
F
IE
H
N
P
RICGVIFDWD
E
Y
S
LDLC
S
D
I
N
QL
-------
NE
Y
LPLYAF
I
NT
H
ST
M
DVS
VQ
---
D
M
R
M
-----
A
L
W
FFEYALG
-
Q
AEDIA
I
R
MR
Q
Y
T
D
EY
LDN
I
T
PP
F
TKALF
T
YV
K
E
R
KYTFCTPGHMGGTA
Y
QKSPVG
C
LFYDFFG
G
NT
L
K
A
D
V
SISVTELGSLLDHTGPH
L
EAE
E
YIAR
T
FGA
EQ
SY
I
VTNGTSTSNKIVGMY
A
AP
S
GST
L
LIDRNCHKSL
A
HLLMM
N
DV
V
PV
W
LK
PTRNA
L
GILGGIP
RR
EF
T
RD
S
I
E
E
KV
A
A
T
T
-----
Q
AQWPVHAVITNSTYDGLLYNTD
W
IK
Q
TLDV
P
S
--
IHFDSAWVPYT
H
F
H
PIY
Q
GK
S
GMSGERV
----
A
GKVIFETQSTHK
M
LAALSQAS
L
IH
I
----
KG
EY
D
EE
A
FNEA
F
MMHTTTSP
S
Y
P
IVAS
V
ETAAAM
L
R
GN
P
GKRLIN
R
S
V
ERA
L
H
FRKE
V
Q
---
RLR
E
E
---
SDGWFFD
I
WQP
PQ
VD
E
--------------------
A
ECWP
V
A
PGE
Q
WHGF
--
N
D
A
D
A
D
HM
F
LDP
V
KVTILTPGM
D
E
Q
G
N
MSE
E
GIPAALVAK
F
LDE
R
GIVVEKTGPYNLLFLFSIGIDKTKA
MG
LLR
G
LT
E
FKR
S
YDLNLR
I
KNMLP
D
LY
A
EDPDFY
R
NMRIQDLAQ
G
IHKLI
RK
H
D
LP
G
LM
L
RAF
DT
LP
E
M
I
MTP
HQ
A
W
Q
RQ
I
K
G
E
VE
T
I
A
LE
Q
LVGR
V
S
ANMILPYPPGVPLLMPGEM
L
T
K
ESR
T
VL
D
FL
L
MLCS
V
G
Q
HYPGFETDIHGA
KQDE
DG
V
Y
R
V
R
VLKMAG
fig|511145.12.peg.193
Escherichia coli str. K-12 substr. MG1655
MN
I
IAI
MGPH
GV
FY
K
D
EPI
K
EL
ES
AL
VA
Q
G
FQII
W
P
Q
N
S
V
DLLK
F
IE
H
N
P
RICGVIFDWD
E
Y
S
LDLC
S
D
I
N
QL
-------
NE
Y
LPLYAF
I
NT
H
ST
M
DVS
VQ
---
D
M
R
M
-----
A
L
W
FFEYALG
-
Q
AEDIA
I
R
MR
Q
Y
T
D
EY
LDN
I
T
PP
F
TKALF
T
YV
K
E
R
KYTFCTPGHMGGTA
Y
QKSPVG
C
LFYDFFG
G
NT
L
K
A
D
V
SISVTELGSLLDHTGPH
L
EAE
E
YIAR
T
FGA
EQ
SY
I
VTNGTSTSNKIVGMY
A
AP
S
GST
L
LIDRNCHKSL
A
HLLMM
N
DV
V
PV
W
LK
PTRNA
L
GILGGIP
RR
EF
T
RD
S
I
E
E
KV
A
A
T
T
-----
Q
AQWPVHAVITNSTYDGLLYNTD
W
IK
Q
TLDV
P
S
--
IHFDSAWVPYT
H
F
H
PIY
Q
GK
S
GMSGERV
----
A
GKVIFETQSTHK
M
LAALSQAS
L
IH
I
----
KG
EY
D
EE
A
FNEA
F
MMHTTTSP
S
Y
P
IVAS
V
ETAAAM
L
R
GN
P
GKRLIN
R
S
V
ERA
L
H
FRKE
V
Q
---
RLR
E
E
---
SDGWFFD
I
WQP
PQ
VD
E
--------------------
A
ECWP
V
A
PGE
Q
WHGF
--
N
D
A
D
A
D
HM
F
LDP
V
KVTILTPGM
D
E
Q
G
N
MSE
E
GIPAALVAK
F
LDE
R
GIVVEKTGPYNLLFLFSIGIDKTKA
MG
LLR
G
LT
E
FKR
S
YDLNLR
I
KNMLP
D
LY
A
EDPDFY
R
NMRIQDLAQ
G
IHKLI
RK
H
D
LP
G
LM
L
RAF
DT
LP
E
M
I
MTP
HQ
A
W
Q
RQ
I
K
G
E
VE
T
I
A
LE
Q
LVGR
V
S
ANMILPYPPGVPLLMPGEM
L
T
K
ESR
T
VL
D
FL
L
MLCS
V
G
Q
HYPGFETDIHGA
KQDE
DG
V
Y
R
V
R
VLKMAG
fig|511145.6.peg.192
Escherichia coli str. K-12 substr. MG1655
MN
I
IAI
MGPH
GV
FY
K
D
EPI
K
EL
ES
AL
VA
Q
G
FQII
W
P
Q
N
S
V
DLLK
F
IE
H
N
P
RICGVIFDWD
E
Y
S
LDLC
S
D
I
N
QL
-------
NE
Y
LPLYAF
I
NT
H
ST
M
DVS
VQ
---
D
M
R
M
-----
A
L
W
FFEYALG
-
Q
AEDIA
I
R
MR
Q
Y
T
D
EY
LDN
I
T
PP
F
TKALF
T
YV
K
E
R
KYTFCTPGHMGGTA
Y
QKSPVG
C
LFYDFFG
G
NT
L
K
A
D
V
SISVTELGSLLDHTGPH
L
EAE
E
YIAR
T
FGA
EQ
SY
I
VTNGTSTSNKIVGMY
A
AP
S
GST
L
LIDRNCHKSL
A
HLLMM
N
DV
V
PV
W
LK
PTRNA
L
GILGGIP
RR
EF
T
RD
S
I
E
E
KV
A
A
T
T
-----
Q
AQWPVHAVITNSTYDGLLYNTD
W
IK
Q
TLDV
P
S
--
IHFDSAWVPYT
H
F
H
PIY
Q
GK
S
GMSGERV
----
A
GKVIFETQSTHK
M
LAALSQAS
L
IH
I
----
KG
EY
D
EE
A
FNEA
F
MMHTTTSP
S
Y
P
IVAS
V
ETAAAM
L
R
GN
P
GKRLIN
R
S
V
ERA
L
H
FRKE
V
Q
---
RLR
E
E
---
SDGWFFD
I
WQP
PQ
VD
E
--------------------
A
ECWP
V
A
PGE
Q
WHGF
--
N
D
A
D
A
D
HM
F
LDP
V
KVTILTPGM
D
E
Q
G
N
MSE
E
GIPAALVAK
F
LDE
R
GIVVEKTGPYNLLFLFSIGIDKTKA
MG
LLR
G
LT
E
FKR
S
YDLNLR
I
KNMLP
D
LY
A
EDPDFY
R
NMRIQDLAQ
G
IHKLI
RK
H
D
LP
G
LM
L
RAF
DT
LP
E
M
I
MTP
HQ
A
W
Q
RQ
I
K
G
E
VE
T
I
A
LE
Q
LVGR
V
S
ANMILPYPPGVPLLMPGEM
L
T
K
ESR
T
VL
D
FL
L
MLCS
V
G
Q
HYPGFETDIHGA
KQDE
DG
V
Y
R
V
R
VLKMAG
fig|550672.3.peg.4457
Escherichia coli B088
MN
I
IAI
MGPH
GV
FY
K
D
EPI
K
EL
ES
AL
VA
Q
G
FQII
W
P
Q
N
S
V
DLLK
F
IE
H
N
P
RICGVIFDWD
E
Y
S
LDLC
S
D
I
N
QL
-------
NE
Y
LPLYAF
I
NT
H
ST
M
DVS
VQ
---
D
M
R
M
-----
A
L
W
FFEYA
M
G
-
Q
AEDIA
I
R
MR
Q
Y
T
D
EY
LDN
I
T
PP
F
TKALF
T
YV
K
E
R
KYTFCTPGHMGGTA
Y
QKSPVG
C
LFYDFFG
G
NT
L
K
A
D
V
SISVTELGSLLDHTGPH
L
EAE
E
YIAR
T
FGA
EQ
SY
I
VTNGTSTSNKIVGMY
A
AP
S
GST
L
LIDRNCHKSL
A
HLLMM
N
DV
V
PV
W
LK
PTRNA
L
GILGGIP
RR
EF
T
RD
S
I
E
E
KV
A
A
T
T
-----
Q
AQWPVHAVITNSTYDGLLYNTD
W
IK
Q
TLDV
P
S
--
IHFDSAWVPYT
H
F
H
PIY
Q
GK
S
GMSGERV
----
A
GKVIFETQSTHK
M
LAALSQAS
L
IH
I
----
KG
EY
D
EE
A
FNEA
F
MMHTTTSP
S
Y
P
IVAS
V
ETAAAM
L
R
GN
P
GKRLIN
R
S
V
ERA
L
H
FRKE
V
Q
---
RLR
E
E
---
SDGWFFD
I
WQP
PQ
VD
E
--------------------
A
ECWP
V
A
PGE
Q
WHGF
--
N
D
A
D
A
D
HM
F
LDP
V
KVTILTPGM
D
E
Q
G
N
MSE
E
GIPAALVAK
F
LDE
R
GIVVEKTGPYNLLFLFSIGIDKTKA
MG
LLR
G
LT
E
FKR
S
YDLNLR
I
KNMLP
D
LY
A
EDPDFY
R
NMRIQDLAQ
G
IHKLI
RK
H
D
LP
G
LM
L
RAF
DT
LP
E
M
I
MTP
HQ
A
W
Q
RQ
I
K
G
E
VE
T
I
A
LE
Q
LVGR
V
S
ANMILPYPPGVPLLMPGEM
L
T
K
ESR
T
VL
D
FL
L
MLCS
V
G
Q
HYPGFETDIHGA
KQDE
DG
V
Y
R
V
R
VLKMAG
fig|562.375.peg.2453
Escherichia coli EC4100B
MN
I
IAI
MGPH
GV
FY
K
D
EPI
K
EL
ES
AL
VA
Q
G
FQII
W
P
Q
N
S
V
DLLK
F
IE
H
N
P
RICGVIFDWD
E
Y
S
LDLC
S
D
I
N
QL
-------
NE
Y
LPLYAF
I
NT
H
ST
M
DVS
VQ
---
D
M
R
M
-----
A
L
W
FFEYA
M
G
-
Q
AEDIA
I
R
MR
Q
Y
T
D
EY
LDN
I
T
PP
F
TKALF
T
YV
K
E
R
KYTFCTPGHMGGTA
Y
QKSPVG
C
LFYDFFG
G
NT
L
K
A
D
V
SISVTELGSLLDHTGPH
L
EAE
E
YIAR
T
FGA
EQ
SY
I
VTNGTSTSNKIVGMY
A
AP
S
GST
L
LIDRNCHKSL
A
HLLMM
N
DV
V
PV
W
LK
PTRNA
L
GILGGIP
RR
EF
T
RD
S
I
E
E
KV
A
A
T
T
-----
Q
AQWPVHAVITNSTYDGLLYNTD
W
IK
Q
TLDV
P
S
--
IHFDSAWVPYT
H
F
H
PIY
Q
GK
S
GMSGERV
----
A
GKVIFETQSTHK
M
LAALSQAS
L
IH
I
----
KG
EY
D
EE
A
FNEA
F
MMHTTTSP
S
Y
P
IVAS
V
ETAAAM
L
R
GN
P
GKRLIN
R
S
V
ERA
L
H
FRKE
V
Q
---
RLR
E
E
---
SDGWFFD
I
WQP
PQ
VD
E
--------------------
A
ECWP
V
A
PGE
Q
WHGF
--
N
D
A
D
A
D
HM
F
LDP
V
KVTILTPGM
D
E
Q
G
N
MSE
E
GIPAALVAK
F
LDE
R
GIVVEKTGPYNLLFLFSIGIDKTKA
MG
LLR
G
LT
E
FKR
S
YDLNLR
I
KNMLP
D
LY
A
EDPDFY
R
NMRIQDLAQ
G
IHKLI
RK
H
D
LP
G
LM
L
RAF
DT
LP
E
M
I
MTP
HQ
A
W
Q
RQ
I
K
G
E
VE
T
I
A
LE
Q
LVGR
V
S
ANMILPYPPGVPLLMPGEM
L
T
K
ESR
T
VL
D
FL
L
MLCS
V
G
Q
HYPGFETDIHGA
KQDE
DG
V
Y
R
V
R
VLKMAG
fig|595495.4.peg.3936
Escherichia coli KO11
MN
I
IAI
MGPH
GV
FY
K
D
EPI
K
EL
ES
AL
VA
Q
G
FQII
W
P
Q
N
S
V
DLLK
F
IE
H
N
P
RICGVIFDWD
E
Y
S
LDLC
S
D
I
N
QL
-------
NE
Y
LPLYAF
I
NT
H
ST
M
DVS
VQ
---
D
M
R
M
-----
A
L
W
FFEYA
M
G
-
Q
AEDIA
I
R
MR
Q
Y
T
D
EY
LDN
I
T
PP
F
TKALF
T
YV
K
E
R
KYTFCTPGHMGGTA
Y
QKSPVG
C
LFYDFFG
G
NT
L
K
A
D
V
SISVTELGSLLDHTGPH
L
EAE
E
YIAR
T
FGA
EQ
SY
I
VTNGTSTSNKIVGMY
A
AP
S
GST
L
LIDRNCHKSL
A
HLLMM
N
DV
V
PV
W
LK
PTRNA
L
GILGGIP
RR
EF
T
RD
S
I
E
E
KV
A
A
T
T
-----
Q
AQWPVHAVITNSTYDGLLYNTD
W
IK
Q
TLDV
P
S
--
IHFDSAWVPYT
H
F
H
PIY
Q
GK
S
GMSGERV
----
A
GKVIFETQSTHK
M
LAALSQAS
L
IH
I
----
KG
EY
D
EE
A
FNEA
F
MMHTTTSP
S
Y
P
IVAS
V
ETAAAM
L
R
GN
P
GKRLIN
R
S
V
ERA
L
H
FRKE
V
Q
---
RLR
E
E
---
SDGWFFD
I
WQP
PQ
VD
E
--------------------
A
ECWP
V
A
PGE
Q
WHGF
--
N
D
A
D
A
D
HM
F
LDP
V
KVTILTPGM
D
E
Q
G
N
MSE
E
GIPAALVAK
F
LDE
R
GIVVEKTGPYNLLFLFSIGIDKTKA
MG
LLR
G
LT
E
FKR
S
YDLNLR
I
KNMLP
D
LY
A
EDPDFY
R
NMRIQDLAQ
G
IHKLI
RK
H
D
LP
G
LM
L
RAF
DT
LP
E
M
I
MTP
HQ
A
W
Q
RQ
I
K
G
E
VE
T
I
A
LE
Q
LVGR
V
S
ANMILPYPPGVPLLMPGEM
L
T
K
ESR
T
VL
D
FL
L
MLCS
V
G
Q
HYPGFETDIHGA
KQDE
DG
V
Y
R
V
R
VLKMAG
fig|566546.3.peg.1536
Escherichia coli W
MN
I
IAI
MGPH
GV
FY
K
D
EPI
K
EL
ES
AL
VA
Q
G
FQII
W
P
Q
N
S
V
DLLK
F
IE
H
N
P
RICGVIFDWD
E
Y
S
LDLC
S
D
I
N
QL
-------
NE
Y
LPLYAF
I
NT
H
ST
M
DVS
VQ
---
D
M
R
M
-----
A
L
W
FFEYA
M
G
-
Q
AEDIA
I
R
MR
Q
Y
T
D
EY
LDN
I
T
PP
F
TKALF
T
YV
K
E
R
KYTFCTPGHMGGTA
Y
QKSPVG
C
LFYDFFG
G
NT
L
K
A
D
V
SISVTELGSLLDHTGPH
L
EAE
E
YIAR
T
FGA
EQ
SY
I
VTNGTSTSNKIVGMY
A
AP
S
GST
L
LIDRNCHKSL
A
HLLMM
N
DV
V
PV
W
LK
PTRNA
L
GILGGIP
RR
EF
T
RD
S
I
E
E
KV
A
A
T
T
-----
Q
AQWPVHAVITNSTYDGLLYNTD
W
IK
Q
TLDV
P
S
--
IHFDSAWVPYT
H
F
H
PIY
Q
GK
S
GMSGERV
----
A
GKVIFETQSTHK
M
LAALSQAS
L
IH
I
----
KG
EY
D
EE
A
FNEA
F
MMHTTTSP
S
Y
P
IVAS
V
ETAAAM
L
R
GN
P
GKRLIN
R
S
V
ERA
L
H
FRKE
V
Q
---
RLR
E
E
---
SDGWFFD
I
WQP
PQ
VD
E
--------------------
A
ECWP
V
A
PGE
Q
WHGF
--
N
D
A
D
A
D
HM
F
LDP
V
KVTILTPGM
D
E
Q
G
N
MSE
E
GIPAALVAK
F
LDE
R
GIVVEKTGPYNLLFLFSIGIDKTKA
MG
LLR
G
LT
E
FKR
S
YDLNLR
I
KNMLP
D
LY
A
EDPDFY
R
NMRIQDLAQ
G
IHKLI
RK
H
D
LP
G
LM
L
RAF
DT
LP
E
M
I
MTP
HQ
A
W
Q
RQ
I
K
G
E
VE
T
I
A
LE
Q
LVGR
V
S
ANMILPYPPGVPLLMPGEM
L
T
K
ESR
T
VL
D
FL
L
MLCS
V
G
Q
HYPGFETDIHGA
KQDE
DG
V
Y
R
V
R
VLKMAG
fig|566546.4.peg.187
Escherichia coli W
MN
I
IAI
MGPH
GV
FY
K
D
EPI
K
EL
ES
AL
VA
Q
G
FQII
W
P
Q
N
S
V
DLLK
F
IE
H
N
P
RICGVIFDWD
E
Y
S
LDLC
S
D
I
N
QL
-------
NE
Y
LPLYAF
I
NT
H
ST
M
DVS
VQ
---
D
M
R
M
-----
A
L
W
FFEYA
M
G
-
Q
AEDIA
I
R
MR
Q
Y
T
D
EY
LDN
I
T
PP
F
TKALF
T
YV
K
E
R
KYTFCTPGHMGGTA
Y
QKSPVG
C
LFYDFFG
G
NT
L
K
A
D
V
SISVTELGSLLDHTGPH
L
EAE
E
YIAR
T
FGA
EQ
SY
I
VTNGTSTSNKIVGMY
A
AP
S
GST
L
LIDRNCHKSL
A
HLLMM
N
DV
V
PV
W
LK
PTRNA
L
GILGGIP
RR
EF
T
RD
S
I
E
E
KV
A
A
T
T
-----
Q
AQWPVHAVITNSTYDGLLYNTD
W
IK
Q
TLDV
P
S
--
IHFDSAWVPYT
H
F
H
PIY
Q
GK
S
GMSGERV
----
A
GKVIFETQSTHK
M
LAALSQAS
L
IH
I
----
KG
EY
D
EE
A
FNEA
F
MMHTTTSP
S
Y
P
IVAS
V
ETAAAM
L
R
GN
P
GKRLIN
R
S
V
ERA
L
H
FRKE
V
Q
---
RLR
E
E
---
SDGWFFD
I
WQP
PQ
VD
E
--------------------
A
ECWP
V
A
PGE
Q
WHGF
--
N
D
A
D
A
D
HM
F
LDP
V
KVTILTPGM
D
E
Q
G
N
MSE
E
GIPAALVAK
F
LDE
R
GIVVEKTGPYNLLFLFSIGIDKTKA
MG
LLR
G
LT
E
FKR
S
YDLNLR
I
KNMLP
D
LY
A
EDPDFY
R
NMRIQDLAQ
G
IHKLI
RK
H
D
LP
G
LM
L
RAF
DT
LP
E
M
I
MTP
HQ
A
W
Q
RQ
I
K
G
E
VE
T
I
A
LE
Q
LVGR
V
S
ANMILPYPPGVPLLMPGEM
L
T
K
ESR
T
VL
D
FL
L
MLCS
V
G
Q
HYPGFETDIHGA
KQDE
DG
V
Y
R
V
R
VLKMAG
fig|358709.5.peg.4682
Escherichia coli 101-1
MN
I
IAI
MGPH
GV
FY
K
D
EPI
K
EL
ES
AL
LA
Q
G
FQII
W
P
Q
N
S
V
DLLK
F
IE
H
N
P
RICGVIFDWD
E
Y
S
LDLC
S
D
I
N
QL
-------
NE
Y
LPLYAF
I
NT
H
ST
M
DVS
VQ
---
D
M
R
M
-----
A
L
W
FFEYALG
-
Q
AEDIA
I
R
MR
Q
Y
T
D
EY
LDN
I
T
PP
F
TKALF
T
YV
K
E
R
KYTFCTPGHMGGTA
Y
QKSPVG
C
LFYDFFG
G
NT
L
K
A
D
V
SISVTELGSLLDHTGPH
L
EAE
E
YIAR
T
FGA
EQ
SY
I
VTNGTSTSNKIVGMY
A
AP
S
GST
L
LIDRNCHKSL
A
HLLMM
N
DV
V
PV
W
LK
PTRNA
L
GILGGIP
RR
EF
T
RD
S
I
E
E
KV
A
A
T
T
-----
Q
AQWPVHAVITNSTYDGLLYNTD
W
IK
Q
TLDV
P
S
--
IHFDSAWVPYT
H
F
H
PIY
Q
GK
S
GMSGERV
----
A
GKVIFETQSTHK
M
LAALSQAS
L
IH
I
----
KG
EY
D
EE
A
FNEA
F
MMHTTTSP
S
Y
P
IVAS
V
ETAAAM
L
R
GN
P
GKRLIN
R
S
V
ERA
L
H
FRKE
V
Q
---
RLR
E
E
---
SDGWFFD
I
WQP
PQ
VD
E
--------------------
A
ECWP
V
A
PGE
Q
WHGF
--
N
D
A
D
A
D
HM
F
LDP
V
KVTILTPGM
D
E
Q
G
N
MSE
E
GIPAALVAK
F
LDE
R
GIVVEKTGPYNLLFLFSIGIDKTKA
MG
LLR
G
LT
E
FKR
S
YDLNLR
I
KNMLP
D
LY
A
EDPDFY
R
NMRIQDLAQ
G
IHKLI
RK
H
D
LP
G
LM
L
RAF
DT
LP
E
M
I
MTP
HQ
A
W
Q
RQ
I
K
G
E
VE
T
I
A
LE
Q
LVGR
V
S
ANMILPYPPGVPLLMPGEM
L
T
K
ESR
T
VL
D
FL
L
MLCS
V
G
Q
HYPGFETDIHGA
KQDE
DG
V
Y
R
V
R
VLKMAG
fig|670888.3.peg.773
Escherichia coli 1827-70
MN
I
IAI
MGPH
GV
FY
K
D
EPI
K
EL
ES
AL
LA
Q
G
FQII
W
P
Q
N
S
V
DLLK
F
IE
H
N
P
RICGVIFDWD
E
Y
S
LDLC
S
D
I
N
QL
-------
NE
Y
LPLYAF
I
NT
H
ST
M
DVS
VQ
---
D
M
R
M
-----
A
L
W
FFEYALG
-
Q
AEDIA
I
R
MR
Q
Y
T
D
EY
LDN
I
T
PP
F
TKALF
T
YV
K
E
R
KYTFCTPGHMGGTA
Y
QKSPVG
C
LFYDFFG
G
NT
L
K
A
D
V
SISVTELGSLLDHTGPH
L
EAE
E
YIAR
T
FGA
EQ
SY
I
VTNGTSTSNKIVGMY
A
AP
S
GST
L
LIDRNCHKSL
A
HLLMM
N
DV
V
PV
W
LK
PTRNA
L
GILGGIP
RR
EF
T
RD
S
I
E
E
KV
A
A
T
T
-----
Q
AQWPVHAVITNSTYDGLLYNTD
W
IK
Q
TLDV
P
S
--
IHFDSAWVPYT
H
F
H
PIY
Q
GK
S
GMSGERV
----
A
GKVIFETQSTHK
M
LAALSQAS
L
IH
I
----
KG
EY
D
EE
A
FNEA
F
MMHTTTSP
S
Y
P
IVAS
V
ETAAAM
L
R
GN
P
GKRLIN
R
S
V
ERA
L
H
FRKE
V
Q
---
RLR
E
E
---
SDGWFFD
I
WQP
PQ
VD
E
--------------------
A
ECWP
V
A
PGE
Q
WHGF
--
N
D
A
D
A
D
HM
F
LDP
V
KVTILTPGM
D
E
Q
G
N
MSE
E
GIPAALVAK
F
LDE
R
GIVVEKTGPYNLLFLFSIGIDKTKA
MG
LLR
G
LT
E
FKR
S
YDLNLR
I
KNMLP
D
LY
A
EDPDFY
R
NMRIQDLAQ
G
IHKLI
RK
H
D
LP
G
LM
L
RAF
DT
LP
E
M
I
MTP
HQ
A
W
Q
RQ
I
K
G
E
VE
T
I
A
LE
Q
LVGR
V
S
ANMILPYPPGVPLLMPGEM
L
T
K
ESR
T
VL
D
FL
L
MLCS
V
G
Q
HYPGFETDIHGA
KQDE
DG
V
Y
R
V
R
VLKMAG
fig|481805.3.peg.3735
Escherichia coli ATCC 8739
MN
I
IAI
MGPH
GV
FY
K
D
EPI
K
EL
ES
AL
LA
Q
G
FQII
W
P
Q
N
S
V
DLLK
F
IE
H
N
P
RICGVIFDWD
E
Y
S
LDLC
S
D
I
N
QL
-------
NE
Y
LPLYAF
I
NT
H
ST
M
DVS
VQ
---
D
M
R
M
-----
A
L
W
FFEYALG
-
Q
AEDIA
I
R
MR
Q
Y
T
D
EY
LDN
I
T
PP
F
TKALF
T
YV
K
E
R
KYTFCTPGHMGGTA
Y
QKSPVG
C
LFYDFFG
G
NT
L
K
A
D
V
SISVTELGSLLDHTGPH
L
EAE
E
YIAR
T
FGA
EQ
SY
I
VTNGTSTSNKIVGMY
A
AP
S
GST
L
LIDRNCHKSL
A
HLLMM
N
DV
V
PV
W
LK
PTRNA
L
GILGGIP
RR
EF
T
RD
S
I
E
E
KV
A
A
T
T
-----
Q
AQWPVHAVITNSTYDGLLYNTD
W
IK
Q
TLDV
P
S
--
IHFDSAWVPYT
H
F
H
PIY
Q
GK
S
GMSGERV
----
A
GKVIFETQSTHK
M
LAALSQAS
L
IH
I
----
KG
EY
D
EE
A
FNEA
F
MMHTTTSP
S
Y
P
IVAS
V
ETAAAM
L
R
GN
P
GKRLIN
R
S
V
ERA
L
H
FRKE
V
Q
---
RLR
E
E
---
SDGWFFD
I
WQP
PQ
VD
E
--------------------
A
ECWP
V
A
PGE
Q
WHGF
--
N
D
A
D
A
D
HM
F
LDP
V
KVTILTPGM
D
E
Q
G
N
MSE
E
GIPAALVAK
F
LDE
R
GIVVEKTGPYNLLFLFSIGIDKTKA
MG
LLR
G
LT
E
FKR
S
YDLNLR
I
KNMLP
D
LY
A
EDPDFY
R
NMRIQDLAQ
G
IHKLI
RK
H
D
LP
G
LM
L
RAF
DT
LP
E
M
I
MTP
HQ
A
W
Q
RQ
I
K
G
E
VE
T
I
A
LE
Q
LVGR
V
S
ANMILPYPPGVPLLMPGEM
L
T
K
ESR
T
VL
D
FL
L
MLCS
V
G
Q
HYPGFETDIHGA
KQDE
DG
V
Y
R
V
R
VLKMAG
fig|481805.6.peg.3712
Escherichia coli ATCC 8739
MN
I
IAI
MGPH
GV
FY
K
D
EPI
K
EL
ES
AL
LA
Q
G
FQII
W
P
Q
N
S
V
DLLK
F
IE
H
N
P
RICGVIFDWD
E
Y
S
LDLC
S
D
I
N
QL
-------
NE
Y
LPLYAF
I
NT
H
ST
M
DVS
VQ
---
D
M
R
M
-----
A
L
W
FFEYALG
-
Q
AEDIA
I
R
MR
Q
Y
T
D
EY
LDN
I
T
PP
F
TKALF
T
YV
K
E
R
KYTFCTPGHMGGTA
Y
QKSPVG
C
LFYDFFG
G
NT
L
K
A
D
V
SISVTELGSLLDHTGPH
L
EAE
E
YIAR
T
FGA
EQ
SY
I
VTNGTSTSNKIVGMY
A
AP
S
GST
L
LIDRNCHKSL
A
HLLMM
N
DV
V
PV
W
LK
PTRNA
L
GILGGIP
RR
EF
T
RD
S
I
E
E
KV
A
A
T
T
-----
Q
AQWPVHAVITNSTYDGLLYNTD
W
IK
Q
TLDV
P
S
--
IHFDSAWVPYT
H
F
H
PIY
Q
GK
S
GMSGERV
----
A
GKVIFETQSTHK
M
LAALSQAS
L
IH
I
----
KG
EY
D
EE
A
FNEA
F
MMHTTTSP
S
Y
P
IVAS
V
ETAAAM
L
R
GN
P
GKRLIN
R
S
V
ERA
L
H
FRKE
V
Q
---
RLR
E
E
---
SDGWFFD
I
WQP
PQ
VD
E
--------------------
A
ECWP
V
A
PGE
Q
WHGF
--
N
D
A
D
A
D
HM
F
LDP
V
KVTILTPGM
D
E
Q
G
N
MSE
E
GIPAALVAK
F
LDE
R
GIVVEKTGPYNLLFLFSIGIDKTKA
MG
LLR
G
LT
E
FKR
S
YDLNLR
I
KNMLP
D
LY
A
EDPDFY
R
NMRIQDLAQ
G
IHKLI
RK
H
D
LP
G
LM
L
RAF
DT
LP
E
M
I
MTP
HQ
A
W
Q
RQ
I
K
G
E
VE
T
I
A
LE
Q
LVGR
V
S
ANMILPYPPGVPLLMPGEM
L
T
K
ESR
T
VL
D
FL
L
MLCS
V
G
Q
HYPGFETDIHGA
KQDE
DG
V
Y
R
V
R
VLKMAG
fig|413997.3.peg.196
Escherichia coli B str. REL606
MN
I
IAI
MGPH
GV
FY
K
D
EPI
K
EL
ES
AL
LA
Q
G
FQII
W
P
Q
N
S
V
DLLK
F
IE
H
N
P
RICGVIFDWD
E
Y
S
LDLC
S
D
I
N
QL
-------
NE
Y
LPLYAF
I
NT
H
ST
M
DVS
VQ
---
D
M
R
M
-----
A
L
W
FFEYALG
-
Q
AEDIA
I
R
MR
Q
Y
T
D
EY
LDN
I
T
PP
F
TKALF
T
YV
K
E
R
KYTFCTPGHMGGTA
Y
QKSPVG
C
LFYDFFG
G
NT
L
K
A
D
V
SISVTELGSLLDHTGPH
L
EAE
E
YIAR
T
FGA
EQ
SY
I
VTNGTSTSNKIVGMY
A
AP
S
GST
L
LIDRNCHKSL
A
HLLMM
N
DV
V
PV
W
LK
PTRNA
L
GILGGIP
RR
EF
T
RD
S
I
E
E
KV
A
A
T
T
-----
Q
AQWPVHAVITNSTYDGLLYNTD
W
IK
Q
TLDV
P
S
--
IHFDSAWVPYT
H
F
H
PIY
Q
GK
S
GMSGERV
----
A
GKVIFETQSTHK
M
LAALSQAS
L
IH
I
----
KG
EY
D
EE
A
FNEA
F
MMHTTTSP
S
Y
P
IVAS
V
ETAAAM
L
R
GN
P
GKRLIN
R
S
V
ERA
L
H
FRKE
V
Q
---
RLR
E
E
---
SDGWFFD
I
WQP
PQ
VD
E
--------------------
A
ECWP
V
A
PGE
Q
WHGF
--
N
D
A
D
A
D
HM
F
LDP
V
KVTILTPGM
D
E
Q
G
N
MSE
E
GIPAALVAK
F
LDE
R
GIVVEKTGPYNLLFLFSIGIDKTKA
MG
LLR
G
LT
E
FKR
S
YDLNLR
I
KNMLP
D
LY
A
EDPDFY
R
NMRIQDLAQ
G
IHKLI
RK
H
D
LP
G
LM
L
RAF
DT
LP
E
M
I
MTP
HQ
A
W
Q
RQ
I
K
G
E
VE
T
I
A
LE
Q
LVGR
V
S
ANMILPYPPGVPLLMPGEM
L
T
K
ESR
T
VL
D
FL
L
MLCS
V
G
Q
HYPGFETDIHGA
KQDE
DG
V
Y
R
V
R
VLKMAG
fig|511693.5.peg.197
Escherichia coli BL21
MN
I
IAI
MGPH
GV
FY
K
D
EPI
K
EL
ES
AL
LA
Q
G
FQII
W
P
Q
N
S
V
DLLK
F
IE
H
N
P
RICGVIFDWD
E
Y
S
LDLC
S
D
I
N
QL
-------
NE
Y
LPLYAF
I
NT
H
ST
M
DVS
VQ
---
D
M
R
M
-----
A
L
W
FFEYALG
-
Q
AEDIA
I
R
MR
Q
Y
T
D
EY
LDN
I
T
PP
F
TKALF
T
YV
K
E
R
KYTFCTPGHMGGTA
Y
QKSPVG
C
LFYDFFG
G
NT
L
K
A
D
V
SISVTELGSLLDHTGPH
L
EAE
E
YIAR
T
FGA
EQ
SY
I
VTNGTSTSNKIVGMY
A
AP
S
GST
L
LIDRNCHKSL
A
HLLMM
N
DV
V
PV
W
LK
PTRNA
L
GILGGIP
RR
EF
T
RD
S
I
E
E
KV
A
A
T
T
-----
Q
AQWPVHAVITNSTYDGLLYNTD
W
IK
Q
TLDV
P
S
--
IHFDSAWVPYT
H
F
H
PIY
Q
GK
S
GMSGERV
----
A
GKVIFETQSTHK
M
LAALSQAS
L
IH
I
----
KG
EY
D
EE
A
FNEA
F
MMHTTTSP
S
Y
P
IVAS
V
ETAAAM
L
R
GN
P
GKRLIN
R
S
V
ERA
L
H
FRKE
V
Q
---
RLR
E
E
---
SDGWFFD
I
WQP
PQ
VD
E
--------------------
A
ECWP
V
A
PGE
Q
WHGF
--
N
D
A
D
A
D
HM
F
LDP
V
KVTILTPGM
D
E
Q
G
N
MSE
E
GIPAALVAK
F
LDE
R
GIVVEKTGPYNLLFLFSIGIDKTKA
MG
LLR
G
LT
E
FKR
S
YDLNLR
I
KNMLP
D
LY
A
EDPDFY
R
NMRIQDLAQ
G
IHKLI
RK
H
D
LP
G
LM
L
RAF
DT
LP
E
M
I
MTP
HQ
A
W
Q
RQ
I
K
G
E
VE
T
I
A
LE
Q
LVGR
V
S
ANMILPYPPGVPLLMPGEM
L
T
K
ESR
T
VL
D
FL
L
MLCS
V
G
Q
HYPGFETDIHGA
KQDE
DG
V
Y
R
V
R
VLKMAG
fig|469008.4.peg.3546
Escherichia coli BL21(DE3)
MN
I
IAI
MGPH
GV
FY
K
D
EPI
K
EL
ES
AL
LA
Q
G
FQII
W
P
Q
N
S
V
DLLK
F
IE
H
N
P
RICGVIFDWD
E
Y
S
LDLC
S
D
I
N
QL
-------
NE
Y
LPLYAF
I
NT
H
ST
M
DVS
VQ
---
D
M
R
M
-----
A
L
W
FFEYALG
-
Q
AEDIA
I
R
MR
Q
Y
T
D
EY
LDN
I
T
PP
F
TKALF
T
YV
K
E
R
KYTFCTPGHMGGTA
Y
QKSPVG
C
LFYDFFG
G
NT
L
K
A
D
V
SISVTELGSLLDHTGPH
L
EAE
E
YIAR
T
FGA
EQ
SY
I
VTNGTSTSNKIVGMY
A
AP
S
GST
L
LIDRNCHKSL
A
HLLMM
N
DV
V
PV
W
LK
PTRNA
L
GILGGIP
RR
EF
T
RD
S
I
E
E
KV
A
A
T
T
-----
Q
AQWPVHAVITNSTYDGLLYNTD
W
IK
Q
TLDV
P
S
--
IHFDSAWVPYT
H
F
H
PIY
Q
GK
S
GMSGERV
----
A
GKVIFETQSTHK
M
LAALSQAS
L
IH
I
----
KG
EY
D
EE
A
FNEA
F
MMHTTTSP
S
Y
P
IVAS
V
ETAAAM
L
R
GN
P
GKRLIN
R
S
V
ERA
L
H
FRKE
V
Q
---
RLR
E
E
---
SDGWFFD
I
WQP
PQ
VD
E
--------------------
A
ECWP
V
A
PGE
Q
WHGF
--
N
D
A
D
A
D
HM
F
LDP
V
KVTILTPGM
D
E
Q
G
N
MSE
E
GIPAALVAK
F
LDE
R
GIVVEKTGPYNLLFLFSIGIDKTKA
MG
LLR
G
LT
E
FKR
S
YDLNLR
I
KNMLP
D
LY
A
EDPDFY
R
NMRIQDLAQ
G
IHKLI
RK
H
D
LP
G
LM
L
RAF
DT
LP
E
M
I
MTP
HQ
A
W
Q
RQ
I
K
G
E
VE
T
I
A
LE
Q
LVGR
V
S
ANMILPYPPGVPLLMPGEM
L
T
K
ESR
T
VL
D
FL
L
MLCS
V
G
Q
HYPGFETDIHGA
KQDE
DG
V
Y
R
V
R
VLKMAG
fig|749547.3.peg.4182
Escherichia coli MS 187-1
MN
I
IAI
MGPH
GV
FY
K
D
EPI
K
EL
ES
AL
LA
Q
G
FQII
W
P
Q
N
S
V
DLLK
F
IE
H
N
P
RICGVIFDWD
E
Y
S
LDLC
S
D
I
N
QL
-------
NE
Y
LPLYAF
I
NT
H
ST
M
DVS
VQ
---
D
M
R
M
-----
A
L
W
FFEYALG
-
Q
AEDIA
I
R
MR
Q
Y
T
D
EY
LDN
I
T
PP
F
TKALF
T
YV
K
E
R
KYTFCTPGHMGGTA
Y
QKSPVG
C
LFYDFFG
G
NT
L
K
A
D
V
SISVTELGSLLDHTGPH
L
EAE
E
YIAR
T
FGA
EQ
SY
I
VTNGTSTSNKIVGMY
A
AP
S
GST
L
LIDRNCHKSL
A
HLLMM
N
DV
V
PV
W
LK
PTRNA
L
GILGGIP
RR
EF
T
RD
S
I
E
E
KV
A
A
T
T
-----
Q
AQWPVHAVITNSTYDGLLYNTD
W
IK
Q
TLDV
P
S
--
IHFDSAWVPYT
H
F
H
PIY
Q
GK
S
GMSGERV
----
A
GKVIFETQSTHK
M
LAALSQAS
L
IH
I
----
KG
EY
D
EE
A
FNEA
F
MMHTTTSP
S
Y
P
IVAS
V
ETAAAM
L
R
GN
P
GKRLIN
R
S
V
ERA
L
H
FRKE
V
Q
---
RLR
E
E
---
SDGWFFD
I
WQP
PQ
VD
E
--------------------
A
ECWP
V
A
PGE
Q
WHGF
--
N
D
A
D
A
D
HM
F
LDP
V
KVTILTPGM
D
E
Q
G
N
MSE
E
GIPAALVAK
F
LDE
R
GIVVEKTGPYNLLFLFSIGIDKTKA
MG
LLR
G
LT
E
FKR
S
YDLNLR
I
KNMLP
D
LY
A
EDPDFY
R
NMRIQDLAQ
G
IHKLI
RK
H
D
LP
G
LM
L
RAF
DT
LP
E
M
I
MTP
HQ
A
W
Q
RQ
I
K
G
E
VE
T
I
A
LE
Q
LVGR
V
S
ANMILPYPPGVPLLMPGEM
L
T
K
ESR
T
VL
D
FL
L
MLCS
V
G
Q
HYPGFETDIHGA
KQDE
DG
V
Y
R
V
R
VLKMAG
fig|656419.3.peg.353
Escherichia coli M718
MN
I
IAI
MGPH
GV
FY
K
D
EPI
K
EL
ES
AL
VA
Q
G
FQII
W
P
Q
N
S
V
DLLK
F
IE
H
N
P
RICGVIFDWD
E
Y
S
LDLC
S
D
I
N
QL
-------
NE
Y
LPLYAF
I
NT
H
ST
M
DVS
VQ
---
D
M
R
M
-----
A
L
W
FFEYALG
-
Q
AEDIA
I
R
MR
Q
Y
T
D
EY
LDN
I
T
PP
F
TKALF
T
YV
K
E
R
KYTFCTPGHMGGTA
Y
QKSPVG
C
LFYDFFG
G
NT
L
K
A
D
V
SISVTELGSLLDHTGPH
L
EAE
E
YIAR
T
FGA
EQ
SY
I
VTNGTSTSNKIVGMY
A
AP
S
GST
L
LIDRNCHKSL
A
HLLMM
N
DV
V
PV
W
LK
PTRNA
L
GILGGIP
RR
EF
T
RD
S
I
E
E
KV
A
A
T
T
-----
Q
AQWPVHAVITNSTYDGLLYNTD
W
IK
Q
TLDV
P
S
--
IHFDSAWVPYT
H
F
H
PIY
Q
GK
S
GMSGERV
----
A
GKVIFETQSTHK
M
LAALSQAS
L
IH
I
----
KG
EY
D
EE
A
FNEA
F
MMHTTTSP
S
Y
P
IVAS
V
ETAAAM
L
R
GN
P
GKRLIN
R
S
V
ERA
L
H
FRKE
V
Q
---
RLR
E
E
---
SDGWFFD
I
WQP
PQ
VD
E
--------------------
A
ECWP
V
A
PGE
E
WHGF
--
N
D
A
D
A
D
HM
F
LDP
V
KVTILTPGM
D
E
Q
G
N
MSE
E
GIPAALVAK
F
LDE
R
GIVVEKTGPYNLLFLFSIGIDKTKA
MG
LLR
G
LT
E
FKR
S
YDLNLR
I
KNMLP
D
LY
A
EDPDFY
R
NMRIQDLAQ
G
IHKLI
RK
H
D
LP
G
LM
L
RAF
DT
LP
E
M
I
MTP
HQ
A
W
Q
RQ
I
K
G
E
VE
T
I
A
LE
Q
LVGR
V
S
ANMILPYPPGVPLLMPGEM
L
T
K
ESR
T
VL
D
FL
L
MLCS
V
G
Q
HYPGFETDIHGA
KQDE
DG
V
Y
R
V
R
VLKMAG
fig|340186.3.peg.705
Escherichia coli E110019
MN
I
IAI
MGPH
GV
FY
K
D
EPI
K
EL
ES
AL
VA
Q
G
FQII
W
P
Q
N
S
V
DLLK
F
IE
H
N
P
RICGVIFDWD
E
Y
S
LDLC
S
D
I
N
QL
-------
NE
Y
LPLYAF
I
NT
H
ST
M
DVS
VQ
---
D
M
R
M
-----
A
L
W
FFEYALG
-
Q
AEDIA
I
R
MR
Q
Y
T
N
EY
LDN
I
T
PP
F
TKALF
T
YV
K
E
R
KYTFCTPGHMGGTA
Y
QKSPVG
C
LFYDFFG
G
NT
L
K
A
D
V
SISVTELGSLLDHTGPH
L
EAE
E
YIAR
T
FGA
EQ
SY
I
VTNGTSTSNKIVGMY
A
AP
S
GST
L
LIDRNCHKSL
A
HLLMM
N
DV
V
PV
W
LK
PTRNA
L
GILGGIP
RR
EF
T
RD
S
I
E
E
KV
A
A
T
T
-----
Q
AQWPVHAVITNSTYDGLLYNTD
W
IK
Q
TLDV
P
S
--
IHFDSAWVPYT
H
F
H
PIY
Q
GK
S
GMSGERV
----
A
GKVIFETQSTHK
M
LAALSQAS
L
IH
I
----
KG
EY
D
EE
A
FNEA
F
MMHTTTSP
S
Y
P
IVAS
V
ETAAAM
L
R
GN
P
GKRLIN
R
S
V
ERA
L
H
FRKE
V
Q
---
RLR
E
E
---
SDGWFFD
I
WQP
PQ
VD
E
--------------------
A
ECWP
V
A
PGE
Q
WHGF
--
N
D
A
D
A
D
HM
F
LDP
V
KVTILTPGM
D
E
Q
G
N
MSE
E
GIPAALVAK
F
LDE
R
GIVVEKTGPYNLLFLFSIGIDKTKA
MG
LLR
G
LT
E
FKR
S
YDLNLR
I
KNMLP
D
LY
A
EDPDFY
R
NMRIQDLAQ
G
IHKLI
RK
H
D
LP
G
LM
L
RAF
DT
LP
E
M
I
MTP
HQ
A
W
Q
RQ
I
K
G
E
VE
T
I
A
LE
Q
LVGR
V
S
ANMILPYPPGVPLLMPGEM
L
T
K
ESR
T
VL
D
FL
L
MLCS
V
G
Q
HYPGFETDIHGA
KQDE
DG
V
Y
R
V
R
VLKMAG
fig|340186.5.peg.731
Escherichia coli E110019
MN
I
IAI
MGPH
GV
FY
K
D
EPI
K
EL
ES
AL
VA
Q
G
FQII
W
P
Q
N
S
V
DLLK
F
IE
H
N
P
RICGVIFDWD
E
Y
S
LDLC
S
D
I
N
QL
-------
NE
Y
LPLYAF
I
NT
H
ST
M
DVS
VQ
---
D
M
R
M
-----
A
L
W
FFEYALG
-
Q
AEDIA
I
R
MR
Q
Y
T
N
EY
LDN
I
T
PP
F
TKALF
T
YV
K
E
R
KYTFCTPGHMGGTA
Y
QKSPVG
C
LFYDFFG
G
NT
L
K
A
D
V
SISVTELGSLLDHTGPH
L
EAE
E
YIAR
T
FGA
EQ
SY
I
VTNGTSTSNKIVGMY
A
AP
S
GST
L
LIDRNCHKSL
A
HLLMM
N
DV
V
PV
W
LK
PTRNA
L
GILGGIP
RR
EF
T
RD
S
I
E
E
KV
A
A
T
T
-----
Q
AQWPVHAVITNSTYDGLLYNTD
W
IK
Q
TLDV
P
S
--
IHFDSAWVPYT
H
F
H
PIY
Q
GK
S
GMSGERV
----
A
GKVIFETQSTHK
M
LAALSQAS
L
IH
I
----
KG
EY
D
EE
A
FNEA
F
MMHTTTSP
S
Y
P
IVAS
V
ETAAAM
L
R
GN
P
GKRLIN
R
S
V
ERA
L
H
FRKE
V
Q
---
RLR
E
E
---
SDGWFFD
I
WQP
PQ
VD
E
--------------------
A
ECWP
V
A
PGE
Q
WHGF
--
N
D
A
D
A
D
HM
F
LDP
V
KVTILTPGM
D
E
Q
G
N
MSE
E
GIPAALVAK
F
LDE
R
GIVVEKTGPYNLLFLFSIGIDKTKA
MG
LLR
G
LT
E
FKR
S
YDLNLR
I
KNMLP
D
LY
A
EDPDFY
R
NMRIQDLAQ
G
IHKLI
RK
H
D
LP
G
LM
L
RAF
DT
LP
E
M
I
MTP
HQ
A
W
Q
RQ
I
K
G
E
VE
T
I
A
LE
Q
LVGR
V
S
ANMILPYPPGVPLLMPGEM
L
T
K
ESR
T
VL
D
FL
L
MLCS
V
G
Q
HYPGFETDIHGA
KQDE
DG
V
Y
R
V
R
VLKMAG
fig|316401.4.peg.203
Escherichia coli ETEC H10407
MN
I
IAI
MGPH
GV
FY
K
D
EPI
K
EL
ES
AL
VA
Q
G
FQII
W
P
Q
N
S
V
DLLK
F
IE
H
N
P
RICGVIFDWD
E
Y
S
LDLC
S
D
I
N
QL
-------
NE
Y
LPLYAF
I
NT
H
ST
M
DVS
VQ
---
D
M
R
M
-----
A
L
W
FFEYALG
-
Q
AEDIA
I
R
MR
Q
Y
T
N
EY
LDN
I
T
PP
F
TKALF
T
YV
K
E
R
KYTFCTPGHMGGTA
Y
QKSPVG
C
LFYDFFG
G
NT
L
K
A
D
V
SISVTELGSLLDHTGPH
L
EAE
E
YIAR
T
FGA
EQ
SY
I
VTNGTSTSNKIVGMY
A
AP
S
GST
L
LIDRNCHKSL
A
HLLMM
N
DV
V
PV
W
LK
PTRNA
L
GILGGIP
RR
EF
T
RD
S
I
E
E
KV
A
A
T
T
-----
Q
AQWPVHAVITNSTYDGLLYNTD
W
IK
Q
TLDV
P
S
--
IHFDSAWVPYT
H
F
H
PIY
Q
GK
S
GMSGERV
----
A
GKVIFETQSTHK
M
LAALSQAS
L
IH
I
----
KG
EY
D
EE
A
FNEA
F
MMHTTTSP
S
Y
P
IVAS
V
ETAAAM
L
R
GN
P
GKRLIN
R
S
V
ERA
L
H
FRKE
V
Q
---
RLR
E
E
---
SDGWFFD
I
WQP
PQ
VD
E
--------------------
A
ECWP
V
A
PGE
Q
WHGF
--
N
D
A
D
A
D
HM
F
LDP
V
KVTILTPGM
D
E
Q
G
N
MSE
E
GIPAALVAK
F
LDE
R
GIVVEKTGPYNLLFLFSIGIDKTKA
MG
LLR
G
LT
E
FKR
S
YDLNLR
I
KNMLP
D
LY
A
EDPDFY
R
NMRIQDLAQ
G
IHKLI
RK
H
D
LP
G
LM
L
RAF
DT
LP
E
M
I
MTP
HQ
A
W
Q
RQ
I
K
G
E
VE
T
I
A
LE
Q
LVGR
V
S
ANMILPYPPGVPLLMPGEM
L
T
K
ESR
T
VL
D
FL
L
MLCS
V
G
Q
HYPGFETDIHGA
KQDE
DG
V
Y
R
V
R
VLKMAG
fig|749545.3.peg.1173
Escherichia coli MS 182-1
MN
I
IAI
MGPH
GV
FY
K
D
EPI
K
EL
ES
AL
VA
Q
G
FQII
W
P
Q
N
S
V
DLLK
F
IE
H
N
P
RICGVIFDWD
E
Y
S
LDLC
S
D
I
N
QL
-------
NE
Y
LPLYAF
I
NT
H
ST
M
DVS
VQ
---
D
M
R
M
-----
A
L
W
FFEYALG
-
Q
AEDIA
I
R
MR
Q
Y
T
D
EY
LDN
I
T
PP
F
TKALF
T
YV
K
E
R
KYTFCTPGHMGGTA
Y
QKSPVG
C
LFYDFFG
G
NT
L
K
A
D
V
SISVTELGSLLDHTGPH
L
EAE
E
YIAR
T
FGA
EQ
SY
I
VTNGTSTSNKIVGMY
A
AP
S
GST
L
LIDRNCHKSL
A
HLLMM
N
DV
V
PV
W
LK
PTRNA
L
GILGGIP
RR
EF
T
RD
S
I
E
E
KV
A
A
T
T
-----
Q
AQWPVHAVITNSTYDGLLYNTD
W
IK
Q
TLDV
P
S
--
IHFDSAWVPYT
H
F
H
PIY
Q
GK
S
GMSGERV
----
A
GKVIFETQSTHK
M
LAALSQAS
L
IH
I
----
KG
EY
D
EE
A
FNEA
F
MMHTTTSP
S
Y
P
IVAS
V
ETAAAM
L
R
GN
P
GKRLIN
R
S
V
ERA
L
H
FRKE
V
Q
---
RLR
E
E
---
SDGWFFD
I
WQP
PQ
VD
E
--------------------
A
ECWP
V
A
PGE
Q
WHGF
--
N
D
A
D
A
D
HM
F
LDP
V
KVTILTPGM
D
E
Q
G
N
MSE
E
GIPAALVAK
F
LDE
R
GIVVEKTGPYNLLFLFSIGIDKTKA
MG
LLR
G
LT
E
FKR
S
YDLNLR
I
KNMLP
D
LY
A
EDPDFY
R
NMRIQDLAQ
G
IHKLI
HK
H
D
LP
G
LM
L
RAF
DT
LP
E
M
I
MTP
HQ
A
W
Q
RQ
I
K
G
E
VE
T
I
A
LE
Q
LVGR
V
S
ANMILPYPPGVPLLMPGEM
L
T
K
ESR
T
VL
D
FL
L
MLCS
V
G
Q
HYPGFETDIHGA
KQDE
DG
V
Y
R
V
R
VLKMAG
fig|749532.3.peg.4149
Escherichia coli MS 78-1
MN
I
IAI
MGPH
GV
FY
K
D
EPI
K
EL
ES
AL
VA
Q
G
FQII
W
P
Q
N
S
V
DLLK
F
IE
H
N
P
RICGVIFDWD
E
Y
S
LDLC
S
D
I
N
QL
-------
NE
Y
LPLYAF
I
NT
H
ST
M
DVS
VQ
---
D
M
R
M
-----
A
L
W
FFEYALG
-
Q
AEDIA
I
R
MR
Q
Y
T
D
EY
LDN
I
T
PP
F
TKALF
T
YV
K
E
R
KYTFCTPGHMGGTA
Y
QKSPVG
C
LFYDFFG
G
NT
L
K
A
D
V
SISVTELGSLLDHTGPH
L
EAE
E
YIAR
T
FGA
EQ
SY
I
VTNGTSTSNKIVGMY
A
AP
S
GST
L
LIDRNCHKSL
A
HLLMM
N
DV
V
PV
W
LK
PTRNA
L
GILGGIP
RR
EF
T
RD
S
I
E
E
KV
A
A
T
T
-----
Q
AQWPVHAVITNSTYDGLLYNTD
W
IK
Q
TLDV
P
S
--
IHFDSAWVPYT
H
F
H
PIY
Q
GK
S
GMSGERV
----
A
GKVIFETQSTHK
M
LAALSQAS
L
IH
I
----
KG
EY
D
EE
A
FNEA
F
MMHTTTSP
S
Y
P
IVAS
V
ETAAAM
L
R
GN
P
GKRLIN
R
S
V
ERA
L
H
FRKE
V
Q
---
RLR
E
E
---
SDGWFFD
I
WQP
PQ
VD
E
--------------------
A
ECWP
V
A
PGE
Q
WHGF
--
N
D
A
D
A
D
HM
F
LDP
V
KVTILTPGM
D
E
Q
G
N
MSE
E
GIPAALVAK
F
LDE
R
GIVVEKTGPYNLLFLFSIGIDKTKA
MG
LLR
G
LT
E
FKR
S
YDLNLR
I
KNMLP
D
LY
A
EDPDFY
R
NMRIQDLAQ
G
IHKLI
HK
H
D
LP
G
LM
L
RAF
DT
LP
E
M
I
MTP
HQ
A
W
Q
RQ
I
K
G
E
VE
T
I
A
LE
Q
LVGR
V
S
ANMILPYPPGVPLLMPGEM
L
T
K
ESR
T
VL
D
FL
L
MLCS
V
G
Q
HYPGFETDIHGA
KQDE
DG
V
Y
R
V
R
VLKMAG
fig|749537.3.peg.3614
Escherichia coli MS 115-1
MN
I
IAI
MGPH
GV
FY
K
D
EPI
K
EL
ES
AL
VV
Q
G
FQII
W
P
Q
N
S
V
DLLK
F
IE
H
N
P
RICGVIFDWD
E
Y
S
LDLC
S
D
I
N
QL
-------
NE
Y
LPLYAF
I
NT
H
ST
M
DVS
VQ
---
D
M
R
M
-----
A
L
W
FFEYALG
-
Q
AEDIA
I
R
MR
Q
Y
T
N
EY
LDN
I
T
PP
F
TKALF
T
YV
K
E
R
KYTFCTPGHMGGTA
Y
QKSPVG
C
LFYDFFG
G
NT
L
K
A
D
V
SISVTELGSLLDHTGPH
L
EAE
E
YIAR
T
FGA
EQ
SY
I
VTNGTSTSNKIVGMY
A
AP
S
GST
L
LIDRNCHKSL
A
HLLMM
N
DV
V
PV
W
LK
PTRNA
L
GILGGIP
RR
EF
T
RD
S
I
E
E
KV
A
A
T
T
-----
Q
AQWPVHAVITNSTYDGLLYNTD
W
IK
Q
TLDV
P
S
--
IHFDSAWVPYT
H
F
H
PIY
Q
GK
S
GMSGERV
----
A
GKVIFETQSTHK
M
LAALSQAS
L
IH
I
----
KG
EY
D
EE
A
FNEA
F
MMHTTTSP
S
Y
P
IVAS
V
ETAAAM
L
R
GN
P
GKRLIN
R
S
V
ERA
L
H
FRKE
V
Q
---
RLR
E
E
---
SDGWFFD
I
WQP
PQ
VD
E
--------------------
A
ECWP
V
A
PGE
Q
WHGF
--
N
D
A
D
A
D
HM
F
LDP
V
KVTILTPGM
D
E
Q
G
N
MSE
E
GIPAALVAK
F
LDE
R
GIVVEKTGPYNLLFLFSIGIDKTKA
MG
LLR
G
LT
E
FKR
S
YDLNLR
I
KNMLP
D
LY
A
EDPDFY
R
NMRIQDLAQ
G
IHKLI
RK
H
D
LP
G
LM
L
RAF
DT
LP
E
M
I
MTP
HQ
A
W
Q
RQ
I
K
G
E
VE
T
I
A
LE
Q
LVGR
V
S
ANMILPYPPGVPLLMPGEM
L
T
K
ESR
T
VL
D
FL
L
MLCS
V
G
Q
HYPGFETDIHGA
KQDE
DG
V
Y
R
V
R
VLKMAG
fig|344601.3.peg.2638
Escherichia coli B171
MN
I
IAI
MGPH
GV
FY
K
D
EPI
K
EL
ES
AL
VA
Q
G
FQII
W
P
Q
N
S
V
DLLK
F
IE
H
N
P
RICGVIFDWD
E
Y
S
LDLC
S
D
I
N
QL
-------
NE
Y
LPLYAF
I
NT
H
ST
M
DVS
VQ
---
D
M
R
M
-----
A
L
W
FFEYALG
-
Q
AEDIA
I
R
MR
Q
Y
T
D
EY
LDN
I
T
PP
F
TKALF
T
YV
K
E
R
KYTFCTPGHMGGTA
Y
QKSPVG
C
LFYDFFG
G
NT
L
K
A
D
V
SISVTELGSLLDHTGPH
L
EAE
E
YIAR
T
FGA
EQ
SY
I
VTNGTSTSNKIVGMY
A
AP
S
GST
L
LIDRNCHKSL
A
HLLMM
N
DV
V
PV
W
LK
PTRNA
L
GILGGIP
RR
EF
T
RD
S
I
E
E
KV
A
A
T
T
-----
Q
AQWPVHAVITNSTYDGLLYNTD
W
IK
Q
TLDV
P
S
--
IHFDSAWVPYT
H
F
H
PIY
Q
GK
S
GMSGERV
----
A
GKVIFETQSTHK
M
LAALSQAS
L
IH
I
----
KG
EY
D
EE
A
FNEA
F
MMHTTTSP
S
Y
P
IVAS
V
ETAAAM
L
R
GN
P
GKRLIN
R
S
V
ERA
L
H
FRKE
V
Q
---
RLR
E
E
---
SDGWFFD
I
WQP
PQ
VD
E
--------------------
A
ECWP
V
A
PGE
Q
WHGF
--
N
D
A
D
A
D
HM
F
LDP
V
KVTILTPGM
D
E
Q
G
N
MSE
E
GIPAALVAK
F
LDE
R
GIVVEKTGPYNLLFLFSIGIDKTKA
MG
LLR
G
LT
E
FKR
S
YDLNLR
I
KNMLP
D
LY
A
EDPDFY
R
NMRIQDLAQ
G
IHKLI
RK
H
D
LP
G
LM
L
RAF
DT
LP
E
M
I
MTP
HQ
A
W
Q
RQ
I
K
G
E
VE
T
I
A
LE
Q
LVGR
V
S
ANMILPYPPGVPLLMPGEM
L
T
K
ESR
T
VL
D
FL
L
MLCS
V
V
Q
HYPGFETDIHGA
KQDE
DG
V
Y
R
V
R
VLKMAG
fig|344601.5.peg.2743
Escherichia coli B171
MN
I
IAI
MGPH
GV
FY
K
D
EPI
K
EL
ES
AL
VA
Q
G
FQII
W
P
Q
N
S
V
DLLK
F
IE
H
N
P
RICGVIFDWD
E
Y
S
LDLC
S
D
I
N
QL
-------
NE
Y
LPLYAF
I
NT
H
ST
M
DVS
VQ
---
D
M
R
M
-----
A
L
W
FFEYALG
-
Q
AEDIA
I
R
MR
Q
Y
T
D
EY
LDN
I
T
PP
F
TKALF
T
YV
K
E
R
KYTFCTPGHMGGTA
Y
QKSPVG
C
LFYDFFG
G
NT
L
K
A
D
V
SISVTELGSLLDHTGPH
L
EAE
E
YIAR
T
FGA
EQ
SY
I
VTNGTSTSNKIVGMY
A
AP
S
GST
L
LIDRNCHKSL
A
HLLMM
N
DV
V
PV
W
LK
PTRNA
L
GILGGIP
RR
EF
T
RD
S
I
E
E
KV
A
A
T
T
-----
Q
AQWPVHAVITNSTYDGLLYNTD
W
IK
Q
TLDV
P
S
--
IHFDSAWVPYT
H
F
H
PIY
Q
GK
S
GMSGERV
----
A
GKVIFETQSTHK
M
LAALSQAS
L
IH
I
----
KG
EY
D
EE
A
FNEA
F
MMHTTTSP
S
Y
P
IVAS
V
ETAAAM
L
R
GN
P
GKRLIN
R
S
V
ERA
L
H
FRKE
V
Q
---
RLR
E
E
---
SDGWFFD
I
WQP
PQ
VD
E
--------------------
A
ECWP
V
A
PGE
Q
WHGF
--
N
D
A
D
A
D
HM
F
LDP
V
KVTILTPGM
D
E
Q
G
N
MSE
E
GIPAALVAK
F
LDE
R
GIVVEKTGPYNLLFLFSIGIDKTKA
MG
LLR
G
LT
E
FKR
S
YDLNLR
I
KNMLP
D
LY
A
EDPDFY
R
NMRIQDLAQ
G
IHKLI
RK
H
D
LP
G
LM
L
RAF
DT
LP
E
M
I
MTP
HQ
A
W
Q
RQ
I
K
G
E
VE
T
I
A
LE
Q
LVGR
V
S
ANMILPYPPGVPLLMPGEM
L
T
K
ESR
T
VL
D
FL
L
MLCS
V
V
Q
HYPGFETDIHGA
KQDE
DG
V
Y
R
V
R
VLKMAG
fig|340185.3.peg.1566
Escherichia coli E22
MN
I
IAI
MGPH
GV
FY
K
D
EPI
K
EL
ES
AL
VA
Q
G
FQII
W
P
Q
N
S
V
DLLK
F
IE
H
N
P
RICGVIFDWD
E
Y
S
LDLC
S
D
I
N
QL
-------
NE
Y
LPLYAF
I
NT
H
ST
M
DVS
VQ
---
D
M
R
M
-----
A
L
W
FFEYALG
-
Q
AEDIA
I
R
MR
Q
Y
T
D
EY
LDN
I
T
PP
F
TKALF
T
YV
K
E
R
KYTFCTPGHMGGTA
Y
QKSPVG
C
LFYDFFG
G
NT
L
K
A
D
V
SISVTELGSLLDHTGPH
L
EAE
E
YIAR
T
FGA
EQ
SY
I
VTNGTSTSNKIVGMY
A
AP
S
GST
L
LIDRNCHKSL
A
HLLMM
N
DV
V
PV
W
LK
PTRNA
L
GILGGIP
RR
EF
T
RD
S
I
E
E
KV
A
A
T
T
-----
Q
AQWPVHAVITNSTYDGLLYNTD
W
IK
Q
TLDV
P
S
--
IHFDSAWVPYT
H
F
H
PIY
Q
GK
S
GMSGERV
----
A
GKVIFETQSTHK
M
LAALSQAS
L
IH
I
----
KG
EY
D
EE
A
FNEA
F
MMHTTTSP
S
Y
P
IVAS
V
ETAAAM
L
R
GN
P
GKRLIN
R
S
V
ERA
L
H
FRKE
V
Q
---
RLR
E
E
---
SDGWFFD
I
WQP
PQ
VD
E
--------------------
A
ECWP
V
A
PGE
Q
WHGF
--
N
D
A
D
A
D
HM
F
LDP
V
KVTILTPGM
D
E
Q
G
N
MSE
E
GIPAALVAK
F
LDE
R
GIVVEKTGPYNLLFLFSIGIDKTKA
MG
LLR
G
LT
E
FKR
S
YDLNLR
I
KNMLP
D
LY
A
EDPDFY
R
NMRIQDLAQ
G
IHKLI
RK
H
D
LP
G
LM
L
RAF
DT
LP
E
M
I
MTP
HQ
A
W
Q
RQ
I
K
G
E
VE
T
I
A
LE
Q
LVGR
V
S
ANMILPYPPGVPLLMPGEM
L
T
K
ESR
T
VL
D
FL
L
MLCS
V
V
Q
HYPGFETDIHGA
KQDE
DG
V
Y
R
V
R
VLKMAG
fig|340185.4.peg.1655
Escherichia coli E22
MN
I
IAI
MGPH
GV
FY
K
D
EPI
K
EL
ES
AL
VA
Q
G
FQII
W
P
Q
N
S
V
DLLK
F
IE
H
N
P
RICGVIFDWD
E
Y
S
LDLC
S
D
I
N
QL
-------
NE
Y
LPLYAF
I
NT
H
ST
M
DVS
VQ
---
D
M
R
M
-----
A
L
W
FFEYALG
-
Q
AEDIA
I
R
MR
Q
Y
T
D
EY
LDN
I
T
PP
F
TKALF
T
YV
K
E
R
KYTFCTPGHMGGTA
Y
QKSPVG
C
LFYDFFG
G
NT
L
K
A
D
V
SISVTELGSLLDHTGPH
L
EAE
E
YIAR
T
FGA
EQ
SY
I
VTNGTSTSNKIVGMY
A
AP
S
GST
L
LIDRNCHKSL
A
HLLMM
N
DV
V
PV
W
LK
PTRNA
L
GILGGIP
RR
EF
T
RD
S
I
E
E
KV
A
A
T
T
-----
Q
AQWPVHAVITNSTYDGLLYNTD
W
IK
Q
TLDV
P
S
--
IHFDSAWVPYT
H
F
H
PIY
Q
GK
S
GMSGERV
----
A
GKVIFETQSTHK
M
LAALSQAS
L
IH
I
----
KG
EY
D
EE
A
FNEA
F
MMHTTTSP
S
Y
P
IVAS
V
ETAAAM
L
R
GN
P
GKRLIN
R
S
V
ERA
L
H
FRKE
V
Q
---
RLR
E
E
---
SDGWFFD
I
WQP
PQ
VD
E
--------------------
A
ECWP
V
A
PGE
Q
WHGF
--
N
D
A
D
A
D
HM
F
LDP
V
KVTILTPGM
D
E
Q
G
N
MSE
E
GIPAALVAK
F
LDE
R
GIVVEKTGPYNLLFLFSIGIDKTKA
MG
LLR
G
LT
E
FKR
S
YDLNLR
I
KNMLP
D
LY
A
EDPDFY
R
NMRIQDLAQ
G
IHKLI
RK
H
D
LP
G
LM
L
RAF
DT
LP
E
M
I
MTP
HQ
A
W
Q
RQ
I
K
G
E
VE
T
I
A
LE
Q
LVGR
V
S
ANMILPYPPGVPLLMPGEM
L
T
K
ESR
T
VL
D
FL
L
MLCS
V
V
Q
HYPGFETDIHGA
KQDE
DG
V
Y
R
V
R
VLKMAG
fig|585395.4.peg.191
Escherichia coli O103:H2 str. 12009
MN
I
IAI
MGPH
GV
FY
K
D
EPI
K
EL
ES
AL
VA
Q
G
FQII
W
P
Q
N
S
V
DLLK
F
IE
H
N
P
RICGVIFDWD
E
Y
S
LDLC
S
D
I
N
QL
-------
NE
Y
LPLYAF
I
NT
H
ST
M
DVS
VQ
---
D
M
R
M
-----
A
L
W
FFEYALG
-
Q
AEDIA
I
R
MR
Q
Y
T
D
EY
LDN
I
T
PP
F
TKALF
T
YV
K
E
R
KYTFCTPGHMGGTA
Y
QKSPVG
C
LFYDFFG
G
NT
L
K
A
D
V
SISVTELGSLLDHTGPH
L
EAE
E
YIAR
T
FGA
EQ
SY
I
VTNGTSTSNKIVGMY
A
AP
S
GST
L
LIDRNCHKSL
A
HLLMM
N
DV
V
PV
W
LK
PTRNA
L
GILGGIP
RR
EF
T
RD
S
I
E
E
KV
A
A
T
T
-----
Q
AQWPVHAVITNSTYDGLLYNTD
W
IK
Q
TLDV
P
S
--
IHFDSAWVPYT
H
F
H
PIY
Q
GK
S
GMSGERV
----
A
GKVIFETQSTHK
M
LAALSQAS
L
IH
I
----
KG
EY
D
EE
A
FNEA
F
MMHTTTSP
S
Y
P
IVAS
V
ETAAAM
L
R
GN
P
GKRLIN
R
S
V
ERA
L
H
FRKE
V
Q
---
RLR
E
E
---
SDGWFFD
I
WQP
PQ
VD
E
--------------------
A
ECWP
V
A
PGE
Q
WHGF
--
N
D
A
D
A
D
HM
F
LDP
V
KVTILTPGM
D
E
Q
G
N
MSE
E
GIPAALVAK
F
LDE
R
GIVVEKTGPYNLLFLFSIGIDKTKA
MG
LLR
G
LT
E
FKR
S
YDLNLR
I
KNMLP
D
LY
A
EDPDFY
R
NMRIQDLAQ
G
IHKLI
RK
H
D
LP
G
LM
L
RAF
DT
LP
E
M
I
MTP
HQ
A
W
Q
RQ
I
K
G
E
VE
T
I
A
LE
Q
LVGR
V
S
ANMILPYPPGVPLLMPGEM
L
T
K
ESR
T
VL
D
FL
L
MLCS
V
V
Q
HYPGFETDIHGA
KQDE
DG
V
Y
R
V
R
VLKMAG
fig|656444.3.peg.527
Escherichia coli TA280
MN
I
IAI
MGPH
GV
FY
K
D
EPI
K
EL
ES
AL
VA
Q
G
FQII
W
P
Q
N
S
V
DLLK
F
IE
H
N
P
RICGVIFDWD
E
Y
S
LDLC
S
D
I
N
QL
-------
NE
Y
LPLYAF
I
NT
H
ST
M
DVS
VQ
---
D
M
R
M
-----
A
L
W
FFEYALG
-
Q
AEDIA
I
R
MR
Q
Y
T
N
EY
LDN
I
T
PP
F
TKALF
T
YV
K
E
R
KYTFCTPGHMGGTA
Y
QKSPVG
C
LFYDFFG
G
NT
L
K
A
D
V
SISVTELGSLLDHTGPH
L
EAE
E
YIAR
T
FGA
EQ
SY
I
VTNGTSTSNKIVGMY
A
AP
S
GST
L
LIDRNCHKSL
A
HLLMM
N
DV
V
PV
W
LK
PTRNA
L
GILGGIP
RR
EF
T
RD
S
I
E
E
KV
A
A
T
T
-----
Q
AQWPVHAVITNSTYDGLLYNTD
W
IK
Q
TLDV
P
S
--
IHFDSAWVPYT
H
F
H
PIY
Q
GK
S
GMSGERV
----
A
GKVIFETQSTHK
M
LAALSQAS
L
IH
I
----
KG
EY
D
EE
A
FNEA
F
MMHTTTSP
S
Y
P
IVAS
V
ETAAAM
L
R
GN
P
GKRLIN
R
S
V
ERA
L
H
FRKE
V
Q
---
RLR
E
E
---
SDGWFFD
I
WQP
PQ
VD
E
--------------------
A
ECWP
V
A
PGE
R
WHGF
--
N
D
A
D
A
D
HM
F
LDP
V
KVTILTPGM
D
E
Q
G
N
MSE
E
GIPAALVAK
F
LDE
R
GIVVEKTGPYNLLFLFSIGIDKTKA
MG
LLR
G
LT
E
FKR
S
YDLNLR
I
KNMLP
D
LY
A
EDPDFY
R
NMRIQDLAQ
G
IHKLI
RK
H
D
LP
G
LM
L
RAF
DT
LP
E
M
I
MTP
HQ
A
W
Q
RQ
I
K
G
E
VE
T
I
A
LE
Q
LVGR
V
S
ANMILPYPPGVPLLMPGEM
L
T
K
ESR
T
VL
D
FL
L
MLCS
V
G
Q
HYPGFETDIHGA
KQDE
DG
V
Y
R
V
R
VLKMAG
fig|331111.12.peg.522
Escherichia coli E24377A
MN
I
IAI
MGPH
GV
FY
K
D
EPI
K
EL
ES
AL
VA
Q
G
FQII
W
P
Q
N
S
V
DLLK
F
IE
H
N
P
RICGVIFDWD
E
Y
S
LDLC
S
D
I
N
QL
-------
NE
Y
LPLYAF
I
NT
H
ST
M
DVS
VQ
---
D
M
R
M
-----
A
L
W
FFEYALG
-
Q
AEDIA
I
R
MR
Q
Y
T
D
EY
LDN
I
T
PP
F
TKALF
T
YV
K
E
R
KYTFCTPGHMGGTA
Y
QKSPVG
C
LFYDFFG
G
NT
L
K
A
D
V
SISVTELGSLLDHTGPH
L
EAE
E
YIAR
T
FGA
EQ
SY
I
VTNGTSTSNKIVGMY
A
AP
S
GST
L
LIDRNCHKSL
A
HLLMM
N
DV
V
PV
W
LK
PTRNA
L
GILGGIP
RR
EF
T
RD
S
I
E
E
KV
A
A
T
T
-----
Q
AQWPVHAVITNSTYDGLLYNTD
W
IK
Q
TLDV
P
S
--
IHFDSAWVPYT
H
F
H
PIY
Q
GK
S
GMSGERV
----
A
GKVIFETQSTHK
M
LAALSQAS
L
IH
I
----
KG
EY
D
EE
A
FNEA
F
MMHTTTSP
S
Y
P
IVAS
V
ETAAAM
L
R
GN
P
GKRLIN
R
S
V
ERA
L
H
FRKE
V
Q
---
RLR
E
E
---
SDGWFFD
I
WQP
PQ
VD
E
--------------------
A
ECWP
V
A
PGE
Q
WHGF
--
N
D
A
D
A
D
HM
F
LDP
V
KVTILTPGM
D
E
Q
G
N
MSE
E
GIPAALVAK
F
LDE
R
GIVVEKTGPYNLLFLFSIGIDKTKA
MG
LLR
G
LT
E
FKR
S
YDLNLR
I
KNMLP
D
LY
A
EDPDFY
R
NMRIQDLAQ
G
IHKLI
RK
H
D
LP
G
LM
L
RAF
DT
LP
E
M
I
MTP
HQ
A
W
Q
RQ
I
K
G
E
VE
T
I
A
LE
Q
LVGR
V
S
ANMILPYPPGVPLLMPGEM
L
T
K
ESR
T
VL
Y
FL
L
MLCS
V
G
Q
HYPGFETDIHGA
KQDE
DG
V
Y
R
V
R
VLKMAG
fig|331111.3.peg.2759
Escherichia coli E24377A
MN
I
IAI
MGPH
GV
FY
K
D
EPI
K
EL
ES
AL
VA
Q
G
FQII
W
P
Q
N
S
V
DLLK
F
IE
H
N
P
RICGVIFDWD
E
Y
S
LDLC
S
D
I
N
QL
-------
NE
Y
LPLYAF
I
NT
H
ST
M
DVS
VQ
---
D
M
R
M
-----
A
L
W
FFEYALG
-
Q
AEDIA
I
R
MR
Q
Y
T
D
EY
LDN
I
T
PP
F
TKALF
T
YV
K
E
R
KYTFCTPGHMGGTA
Y
QKSPVG
C
LFYDFFG
G
NT
L
K
A
D
V
SISVTELGSLLDHTGPH
L
EAE
E
YIAR
T
FGA
EQ
SY
I
VTNGTSTSNKIVGMY
A
AP
S
GST
L
LIDRNCHKSL
A
HLLMM
N
DV
V
PV
W
LK
PTRNA
L
GILGGIP
RR
EF
T
RD
S
I
E
E
KV
A
A
T
T
-----
Q
AQWPVHAVITNSTYDGLLYNTD
W
IK
Q
TLDV
P
S
--
IHFDSAWVPYT
H
F
H
PIY
Q
GK
S
GMSGERV
----
A
GKVIFETQSTHK
M
LAALSQAS
L
IH
I
----
KG
EY
D
EE
A
FNEA
F
MMHTTTSP
S
Y
P
IVAS
V
ETAAAM
L
R
GN
P
GKRLIN
R
S
V
ERA
L
H
FRKE
V
Q
---
RLR
E
E
---
SDGWFFD
I
WQP
PQ
VD
E
--------------------
A
ECWP
V
A
PGE
Q
WHGF
--
N
D
A
D
A
D
HM
F
LDP
V
KVTILTPGM
D
E
Q
G
N
MSE
E
GIPAALVAK
F
LDE
R
GIVVEKTGPYNLLFLFSIGIDKTKA
MG
LLR
G
LT
E
FKR
S
YDLNLR
I
KNMLP
D
LY
A
EDPDFY
R
NMRIQDLAQ
G
IHKLI
RK
H
D
LP
G
LM
L
RAF
DT
LP
E
M
I
MTP
HQ
A
W
Q
RQ
I
K
G
E
VE
T
I
A
LE
Q
LVGR
V
S
ANMILPYPPGVPLLMPGEM
L
T
K
ESR
T
VL
Y
FL
L
MLCS
V
G
Q
HYPGFETDIHGA
KQDE
DG
V
Y
R
V
R
VLKMAG
fig|216592.1.peg.4218
Escherichia coli 042
MN
I
IAI
MGPH
GV
FY
K
D
EPI
K
EL
ES
AL
VA
Q
G
FQII
W
P
Q
N
S
V
DLLK
F
IE
H
N
P
RICGVIFDWD
E
Y
S
LDLC
S
D
I
N
QL
-------
NE
Y
LPLYAF
I
NT
H
ST
M
DVS
VQ
---
D
M
R
M
-----
A
L
W
FFEYALG
-
Q
AEDIA
I
R
MR
Q
Y
T
D
EY
LDN
I
T
PP
F
TKALF
T
YV
K
E
R
KYTFCTPGHMGGTA
Y
QKSPVG
C
LFYDFFG
G
NT
L
K
A
D
V
SISVTELGSLLDHTGPH
L
EAE
E
YIAR
T
F
D
A
EQ
SY
I
VTNGTSTSNKIVGMY
A
AP
S
GST
L
LIDRNCHKSL
A
HLLMM
N
DV
V
PV
W
LK
PTRNA
L
GILGGIP
RR
EF
S
RD
S
I
E
E
KV
A
A
T
T
-----
Q
AQWPVHAVITNSTYDGLLYNTD
W
IK
Q
TLDV
P
S
--
IHFDSAWVPYT
H
F
H
PIY
Q
GK
S
GMSGERV
----
A
GKVIFETQSTHK
M
LAALSQAS
L
IH
I
----
KG
EY
D
EE
A
FNEA
F
MMHTTTSP
S
Y
P
IVAS
V
ETAAAM
L
R
GN
P
GKRLIN
R
S
V
ERA
L
H
FRKE
V
Q
---
RLR
E
E
---
SDGWFFD
I
WQP
PQ
VD
E
--------------------
A
ECWP
V
A
PGE
Q
WHGF
--
N
D
A
D
A
D
HM
F
LDP
V
KVTILTPGM
D
E
Q
G
N
MSE
E
GIPAALVAK
F
LDE
R
GIVVEKTGPYNLLFLFSIGIDKTKA
MG
LLR
G
LT
E
FKR
S
YDLNLR
I
KNMLP
D
LY
A
EDPDFY
R
NMRIQDLAQ
G
IHKLI
RK
H
D
LP
G
LM
L
RAF
DT
LP
E
M
I
MTP
HQ
A
W
Q
RQ
I
K
G
E
VE
T
I
A
LE
Q
LVGR
V
S
ANMILPYPPGVPLLMPGEM
L
T
K
ESR
T
VL
D
FL
L
MLCS
V
G
Q
HYPGFETDIHGA
KQDE
DG
V
Y
R
V
R
VLKMAG
fig|216592.3.peg.197
Escherichia coli 042
MN
I
IAI
MGPH
GV
FY
K
D
EPI
K
EL
ES
AL
VA
Q
G
FQII
W
P
Q
N
S
V
DLLK
F
IE
H
N
P
RICGVIFDWD
E
Y
S
LDLC
S
D
I
N
QL
-------
NE
Y
LPLYAF
I
NT
H
ST
M
DVS
VQ
---
D
M
R
M
-----
A
L
W
FFEYALG
-
Q
AEDIA
I
R
MR
Q
Y
T
D
EY
LDN
I
T
PP
F
TKALF
T
YV
K
E
R
KYTFCTPGHMGGTA
Y
QKSPVG
C
LFYDFFG
G
NT
L
K
A
D
V
SISVTELGSLLDHTGPH
L
EAE
E
YIAR
T
F
D
A
EQ
SY
I
VTNGTSTSNKIVGMY
A
AP
S
GST
L
LIDRNCHKSL
A
HLLMM
N
DV
V
PV
W
LK
PTRNA
L
GILGGIP
RR
EF
S
RD
S
I
E
E
KV
A
A
T
T
-----
Q
AQWPVHAVITNSTYDGLLYNTD
W
IK
Q
TLDV
P
S
--
IHFDSAWVPYT
H
F
H
PIY
Q
GK
S
GMSGERV
----
A
GKVIFETQSTHK
M
LAALSQAS
L
IH
I
----
KG
EY
D
EE
A
FNEA
F
MMHTTTSP
S
Y
P
IVAS
V
ETAAAM
L
R
GN
P
GKRLIN
R
S
V
ERA
L
H
FRKE
V
Q
---
RLR
E
E
---
SDGWFFD
I
WQP
PQ
VD
E
--------------------
A
ECWP
V
A
PGE
Q
WHGF
--
N
D
A
D
A
D
HM
F
LDP
V
KVTILTPGM
D
E
Q
G
N
MSE
E
GIPAALVAK
F
LDE
R
GIVVEKTGPYNLLFLFSIGIDKTKA
MG
LLR
G
LT
E
FKR
S
YDLNLR
I
KNMLP
D
LY
A
EDPDFY
R
NMRIQDLAQ
G
IHKLI
RK
H
D
LP
G
LM
L
RAF
DT
LP
E
M
I
MTP
HQ
A
W
Q
RQ
I
K
G
E
VE
T
I
A
LE
Q
LVGR
V
S
ANMILPYPPGVPLLMPGEM
L
T
K
ESR
T
VL
D
FL
L
MLCS
V
G
Q
HYPGFETDIHGA
KQDE
DG
V
Y
R
V
R
VLKMAG
fig|656379.3.peg.430
Escherichia coli FVEC1302
MN
I
IAI
MGPH
GV
FY
K
D
EPI
K
EL
ES
AL
VA
Q
G
FQII
W
P
Q
N
S
V
DLLK
F
IE
H
N
P
RICGVIFDWD
E
Y
S
LDLC
S
D
I
N
QL
-------
NE
Y
LPLYAF
I
NT
H
ST
M
DVS
VQ
---
D
M
R
M
-----
A
L
W
FFEYALG
-
Q
AEDIA
I
R
MR
Q
Y
T
D
EY
LDN
I
T
PP
F
TKALF
T
YV
K
E
R
KYTFCTPGHMGGTA
Y
QKSPVG
C
LFYDFFG
G
NT
L
K
A
D
V
SISVTELGSLLDHTGPH
L
EAE
E
YIAR
T
F
D
A
EQ
SY
I
VTNGTSTSNKIVGMY
A
AP
S
GST
L
LIDRNCHKSL
A
HLLMM
N
DV
V
PV
W
LK
PTRNA
L
GILGGIP
RR
EF
S
RD
S
I
E
E
KV
A
A
T
T
-----
Q
AQWPVHAVITNSTYDGLLYNTD
W
IK
Q
TLDV
P
S
--
IHFDSAWVPYT
H
F
H
PIY
Q
GK
S
GMSGERV
----
A
GKVIFETQSTHK
M
LAALSQAS
L
IH
I
----
KG
EY
D
EE
A
FNEA
F
MMHTTTSP
S
Y
P
IVAS
V
ETAAAM
L
R
GN
P
GKRLIN
R
S
V
ERA
L
H
FRKE
V
Q
---
RLR
E
E
---
SDGWFFD
I
WQP
PQ
VD
E
--------------------
A
ECWP
V
A
PGE
Q
WHGF
--
N
D
A
D
A
D
HM
F
LDP
V
KVTILTPGM
D
E
Q
G
N
MSE
E
GIPAALVAK
F
LDE
R
GIVVEKTGPYNLLFLFSIGIDKTKA
MG
LLR
G
LT
E
FKR
S
YDLNLR
I
KNMLP
D
LY
A
EDPDFY
R
NMRIQDLAQ
G
IHKLI
RK
H
D
LP
G
LM
L
RAF
DT
LP
E
M
I
MTP
HQ
A
W
Q
RQ
I
K
G
E
VE
T
I
A
LE
Q
LVGR
V
S
ANMILPYPPGVPLLMPGEM
L
T
K
ESR
T
VL
D
FL
L
MLCS
V
G
Q
HYPGFETDIHGA
KQDE
DG
V
Y
R
V
R
VLKMAG
fig|656380.3.peg.366
Escherichia coli FVEC1412
MN
I
IAI
MGPH
GV
FY
K
D
EPI
K
EL
ES
AL
VA
Q
G
FQII
W
P
Q
N
S
V
DLLK
F
IE
H
N
P
RICGVIFDWD
E
Y
S
LDLC
S
D
I
N
QL
-------
NE
Y
LPLYAF
I
NT
H
ST
M
DVS
VQ
---
D
M
R
M
-----
A
L
W
FFEYALG
-
Q
AEDIA
I
R
MR
Q
Y
T
D
EY
LDN
I
T
PP
F
TKALF
T
YV
K
E
R
KYTFCTPGHMGGTA
Y
QKSPVG
C
LFYDFFG
G
NT
L
K
A
D
V
SISVTELGSLLDHTGPH
L
EAE
E
YIAR
T
F
D
A
EQ
SY
I
VTNGTSTSNKIVGMY
A
AP
S
GST
L
LIDRNCHKSL
A
HLLMM
N
DV
V
PV
W
LK
PTRNA
L
GILGGIP
RR
EF
S
RD
S
I
E
E
KV
A
A
T
T
-----
Q
AQWPVHAVITNSTYDGLLYNTD
W
IK
Q
TLDV
P
S
--
IHFDSAWVPYT
H
F
H
PIY
Q
GK
S
GMSGERV
----
A
GKVIFETQSTHK
M
LAALSQAS
L
IH
I
----
KG
EY
D
EE
A
FNEA
F
MMHTTTSP
S
Y
P
IVAS
V
ETAAAM
L
R
GN
P
GKRLIN
R
S
V
ERA
L
H
FRKE
V
Q
---
RLR
E
E
---
SDGWFFD
I
WQP
PQ
VD
E
--------------------
A
ECWP
V
A
PGE
Q
WHGF
--
N
D
A
D
A
D
HM
F
LDP
V
KVTILTPGM
D
E
Q
G
N
MSE
E
GIPAALVAK
F
LDE
R
GIVVEKTGPYNLLFLFSIGIDKTKA
MG
LLR
G
LT
E
FKR
S
YDLNLR
I
KNMLP
D
LY
A
EDPDFY
R
NMRIQDLAQ
G
IHKLI
RK
H
D
LP
G
LM
L
RAF
DT
LP
E
M
I
MTP
HQ
A
W
Q
RQ
I
K
G
E
VE
T
I
A
LE
Q
LVGR
V
S
ANMILPYPPGVPLLMPGEM
L
T
K
ESR
T
VL
D
FL
L
MLCS
V
G
Q
HYPGFETDIHGA
KQDE
DG
V
Y
R
V
R
VLKMAG
fig|585056.7.peg.377
Escherichia coli UMN026
MN
I
IAI
MGPH
GV
FY
K
D
EPI
K
EL
ES
AL
VA
Q
G
FQII
W
P
Q
N
S
V
DLLK
F
IE
H
N
P
RICGVIFDWD
E
Y
S
LDLC
S
D
I
N
QL
-------
NE
Y
LPLYAF
I
NT
H
ST
M
DVS
VQ
---
D
M
R
M
-----
A
L
W
FFEYALG
-
Q
AEDIA
I
R
MR
Q
Y
T
D
EY
LDN
I
T
PP
F
TKALF
T
YV
K
E
R
KYTFCTPGHMGGTA
Y
QKSPVG
C
LFYDFFG
G
NT
L
K
A
D
V
SISVTELGSLLDHTGPH
L
EAE
E
YIAR
T
F
D
A
EQ
SY
I
VTNGTSTSNKIVGMY
A
AP
S
GST
L
LIDRNCHKSL
A
HLLMM
N
DV
V
PV
W
LK
PTRNA
L
GILGGIP
RR
EF
S
RD
S
I
E
E
KV
A
A
T
T
-----
Q
AQWPVHAVITNSTYDGLLYNTD
W
IK
Q
TLDV
P
S
--
IHFDSAWVPYT
H
F
H
PIY
Q
GK
S
GMSGERV
----
A
GKVIFETQSTHK
M
LAALSQAS
L
IH
I
----
KG
EY
D
EE
A
FNEA
F
MMHTTTSP
S
Y
P
IVAS
V
ETAAAM
L
R
GN
P
GKRLIN
R
S
V
ERA
L
H
FRKE
V
Q
---
RLR
E
E
---
SDGWFFD
I
WQP
PQ
VD
E
--------------------
A
ECWP
V
A
PGE
Q
WHGF
--
N
D
A
D
A
D
HM
F
LDP
V
KVTILTPGM
D
E
Q
G
N
MSE
E
GIPAALVAK
F
LDE
R
GIVVEKTGPYNLLFLFSIGIDKTKA
MG
LLR
G
LT
E
FKR
S
YDLNLR
I
KNMLP
D
LY
A
EDPDFY
R
NMRIQDLAQ
G
IHKLI
RK
H
D
LP
G
LM
L
RAF
DT
LP
E
M
I
MTP
HQ
A
W
Q
RQ
I
K
G
E
VE
T
I
A
LE
Q
LVGR
V
S
ANMILPYPPGVPLLMPGEM
L
T
K
ESR
T
VL
D
FL
L
MLCS
V
G
Q
HYPGFETDIHGA
KQDE
DG
V
Y
R
V
R
VLKMAG
fig|573235.3.peg.193
Escherichia coli O26:H11 str. 11368
MN
I
IAI
MGPH
GV
FY
K
D
EPI
K
EL
ES
AL
VA
Q
G
FQII
W
P
Q
N
S
V
DLLK
F
IE
H
N
P
RICGVIFDWD
E
Y
S
LDLC
S
D
I
N
QL
-------
NE
Y
LPLYAF
I
NT
H
ST
M
DVS
VQ
---
D
M
R
M
-----
A
L
W
FFEYALG
-
Q
AEDIA
I
R
MR
Q
Y
T
D
EY
LDN
I
T
PP
F
TKALF
T
YV
K
E
R
KYTFCTPGHMGGTA
Y
QKSPVG
C
LFYDFFG
G
NT
L
K
A
D
V
SISVTELGSLLDHTGPH
L
EAE
E
YIAR
T
FGA
EQ
SY
I
VTNGTSTSNKIVGMY
A
AP
S
GST
L
LIDRNCHKSL
A
HLLMM
N
DV
V
PV
W
LK
PTRNA
L
GILGGIP
RR
EF
T
RD
S
I
E
E
KV
A
A
T
T
-----
Q
AQWPVHAVITNSTYDGLLYNTD
W
IK
Q
TLDV
P
S
--
IHFDSAWVPYT
H
F
H
PIY
Q
GK
S
GMSGERV
----
A
GKVIFETQSTHK
M
LAALSQAS
L
IH
I
----
KG
EY
D
EE
A
FNEA
F
MMHTTTSP
S
Y
P
IVAS
V
ETAAAM
L
R
GN
P
GKRLIN
R
S
V
ERA
L
H
FRKE
V
Q
---
RLR
E
E
---
SDGWFFD
I
WQP
PQ
VD
E
--------------------
A
ECWP
V
A
L
GE
Q
WHGF
--
N
D
A
D
A
D
HM
F
LDP
V
KVTILTPGM
D
E
Q
G
N
MSE
E
GIPAALVAK
F
LDE
R
GIVVEKTGPYNLLFLFSIGIDKTKA
MG
LLR
G
LT
E
FKR
S
YDLNLR
I
KNMLP
D
LY
A
EDPDFY
R
NMRIQDLAQ
G
IHKLI
RK
H
D
LP
G
LM
L
RAF
DT
LP
E
M
I
MTP
HQ
A
W
Q
RQ
I
K
G
E
VE
T
I
A
LE
Q
LVGR
V
S
ANMILPYPPGVPLLMPGEM
L
T
K
ESR
T
VL
D
FL
L
MLCS
V
G
Q
HYPGFETDIHGA
KQDE
DG
V
Y
R
V
R
VLKMAG
fig|656437.3.peg.254
Escherichia coli TA143
MN
I
IAI
MGPH
GV
FY
K
D
EPI
K
EL
ES
AL
VA
Q
G
FQII
W
P
Q
N
S
V
DLLK
F
IE
H
N
P
RICGVIFDWD
E
Y
S
LDLC
S
D
I
N
QL
-------
NE
Y
LPLYAF
I
NT
H
ST
M
DVS
VQ
---
D
M
R
M
-----
A
L
W
FFEYALG
-
Q
AEDIA
I
R
MR
Q
Y
T
N
EY
LDN
I
T
PP
F
TKALF
T
YV
K
E
R
KYTFCTPGHMGGTA
Y
QKSPVG
C
LFYDFFG
G
NT
L
K
A
D
V
SISVTELGSLLDHTGPH
L
EAE
E
YIAR
T
FGA
EQ
SY
I
VTNGTSTSNKIVGMY
A
AP
S
GST
L
LIDRNCHKSL
A
HLLMM
N
DV
V
PV
W
LK
PTRNA
L
GILGGIP
RR
EF
T
RD
S
I
E
E
KV
A
A
T
T
-----
Q
AQWPVHAVITNSTYDGLLYNTD
W
IK
Q
TLDV
P
S
--
IHFDSAWVPYT
H
F
H
PIY
Q
GK
S
GMSGERV
----
A
GKVIFETQSTHK
M
LAALSQAS
L
IH
I
----
KG
EY
D
EE
A
FNEA
F
MMHTTTSP
S
Y
P
IVAS
V
ETAAAM
L
R
GN
P
GKRLIN
R
S
V
ERA
L
H
FRKE
V
Q
---
RLR
E
E
---
SDGWFFD
I
WQP
PQ
VD
E
--------------------
A
ECWP
V
A
PGE
R
WHGF
--
N
D
A
D
A
D
HM
F
LDP
V
KVTILTPGM
D
E
Q
G
N
MS
D
E
GIPAALVAK
F
LDE
R
GIVVEKTGPYNLLFLFSIGIDKTKA
MG
LLR
G
LT
E
FKR
S
YDLNLR
I
KNMLP
D
LY
A
EDPDFY
R
NMRIQDLAQ
G
IHKLI
RK
H
D
LP
G
LM
L
RAF
DT
LP
E
M
I
MTP
HQ
A
W
Q
RQ
I
K
G
E
VE
T
I
A
LE
Q
LVGR
V
S
ANMILPYPPGVPLLMPGEM
L
T
K
ESR
T
VL
D
FL
L
MLCS
V
G
Q
HYPGFETDIHGA
KQDE
DG
V
Y
R
V
R
VLKMAG
fig|562.371.peg.854
Escherichia coli 1044A
MN
I
IAI
MGPH
GV
FY
K
D
EPI
K
EL
ES
AL
VA
Q
G
FQII
W
P
Q
N
S
V
DLLK
F
IE
H
N
P
RICGVIFDWD
E
Y
S
LDLC
S
D
I
N
QL
-------
NE
Y
LPLYAF
I
NT
H
ST
M
DVS
VQ
---
D
M
R
M
-----
A
L
C
FFEYALG
-
Q
AEDIA
I
R
MR
Q
Y
T
D
EY
LDN
I
T
PP
F
TKALF
T
YV
K
E
R
KYTFCTPGHMGGTA
Y
QKSPVG
C
LFYDFFG
G
NT
L
K
A
D
V
SISVTELGSLLDHTGPH
L
EAE
E
YIAR
T
FGA
EQ
SY
I
VTNGTSTSNKIVGMY
A
AP
S
GST
L
LIDRNCHKSL
A
HLLMM
N
DV
V
PV
W
LK
PTRNA
L
GILGGIP
RR
EF
T
RD
S
I
E
E
KV
A
A
T
T
-----
Q
AQWPVHAVITNSTYDGLLYNTD
W
IK
Q
TLDV
P
S
--
IHFDSAWVPYT
H
F
H
PIY
Q
GK
S
GMSGERV
----
A
GKVIFETQSTHK
M
LAALSQAS
L
IH
I
----
KG
EY
D
EE
A
FNEA
F
MMHTTTSP
S
Y
P
IVAS
V
ETAAAM
L
R
GN
P
GKRLIN
R
S
V
ERA
L
H
FRKE
V
Q
---
RLR
E
E
---
SDGWFFD
I
WQP
PQ
VD
E
--------------------
A
ECWP
V
A
PGE
Q
WHGF
--
N
D
A
D
A
D
HM
F
LDP
V
KVTILTPGM
D
E
Q
G
N
MSE
E
GIPAALVAK
F
LDE
R
GIVVEKTGPYNLLFLFSIGIDKTKA
MG
LLR
G
LT
E
FKR
S
YDLNLR
I
KNMLP
D
LY
A
EDPDFY
R
NMRIQDLAQ
G
IHKLI
RK
H
D
LP
G
LM
L
RAF
DT
LP
E
M
I
MTP
HQ
A
W
Q
RQ
I
K
G
E
VE
T
I
A
LE
Q
LVGR
V
S
ANMILPYPPGVPLLMPGEM
L
T
K
ESR
T
VL
D
FL
L
MLCS
V
G
Q
HYPGFETDIHGA
KQDE
DG
V
Y
R
V
R
VLKMAG
fig|562.373.peg.2072
Escherichia coli 1125A
MN
I
IAI
MGPH
GV
FY
K
D
EPI
K
EL
ES
AL
VA
Q
G
FQII
W
P
Q
N
S
V
DLLK
F
IE
H
N
P
RICGVIFDWD
E
Y
S
LDLC
S
D
I
N
QL
-------
NE
Y
LPLYAF
I
NT
H
ST
M
DVS
VQ
---
D
M
R
M
-----
A
L
C
FFEYALG
-
Q
AEDIA
I
R
MR
Q
Y
T
D
EY
LDN
I
T
PP
F
TKALF
T
YV
K
E
R
KYTFCTPGHMGGTA
Y
QKSPVG
C
LFYDFFG
G
NT
L
K
A
D
V
SISVTELGSLLDHTGPH
L
EAE
E
YIAR
T
FGA
EQ
SY
I
VTNGTSTSNKIVGMY
A
AP
S
GST
L
LIDRNCHKSL
A
HLLMM
N
DV
V
PV
W
LK
PTRNA
L
GILGGIP
RR
EF
T
RD
S
I
E
E
KV
A
A
T
T
-----
Q
AQWPVHAVITNSTYDGLLYNTD
W
IK
Q
TLDV
P
S
--
IHFDSAWVPYT
H
F
H
PIY
Q
GK
S
GMSGERV
----
A
GKVIFETQSTHK
M
LAALSQAS
L
IH
I
----
KG
EY
D
EE
A
FNEA
F
MMHTTTSP
S
Y
P
IVAS
V
ETAAAM
L
R
GN
P
GKRLIN
R
S
V
ERA
L
H
FRKE
V
Q
---
RLR
E
E
---
SDGWFFD
I
WQP
PQ
VD
E
--------------------
A
ECWP
V
A
PGE
Q
WHGF
--
N
D
A
D
A
D
HM
F
LDP
V
KVTILTPGM
D
E
Q
G
N
MSE
E
GIPAALVAK
F
LDE
R
GIVVEKTGPYNLLFLFSIGIDKTKA
MG
LLR
G
LT
E
FKR
S
YDLNLR
I
KNMLP
D
LY
A
EDPDFY
R
NMRIQDLAQ
G
IHKLI
RK
H
D
LP
G
LM
L
RAF
DT
LP
E
M
I
MTP
HQ
A
W
Q
RQ
I
K
G
E
VE
T
I
A
LE
Q
LVGR
V
S
ANMILPYPPGVPLLMPGEM
L
T
K
ESR
T
VL
D
FL
L
MLCS
V
G
Q
HYPGFETDIHGA
KQDE
DG
V
Y
R
V
R
VLKMAG
fig|562.372.peg.2921
Escherichia coli 1212A
MN
I
IAI
MGPH
GV
FY
K
D
EPI
K
EL
ES
AL
VA
Q
G
FQII
W
P
Q
N
S
V
DLLK
F
IE
H
N
P
RICGVIFDWD
E
Y
S
LDLC
S
D
I
N
QL
-------
NE
Y
LPLYAF
I
NT
H
ST
M
DVS
VQ
---
D
M
R
M
-----
A
L
C
FFEYALG
-
Q
AEDIA
I
R
MR
Q
Y
T
D
EY
LDN
I
T
PP
F
TKALF
T
YV
K
E
R
KYTFCTPGHMGGTA
Y
QKSPVG
C
LFYDFFG
G
NT
L
K
A
D
V
SISVTELGSLLDHTGPH
L
EAE
E
YIAR
T
FGA
EQ
SY
I
VTNGTSTSNKIVGMY
A
AP
S
GST
L
LIDRNCHKSL
A
HLLMM
N
DV
V
PV
W
LK
PTRNA
L
GILGGIP
RR
EF
T
RD
S
I
E
E
KV
A
A
T
T
-----
Q
AQWPVHAVITNSTYDGLLYNTD
W
IK
Q
TLDV
P
S
--
IHFDSAWVPYT
H
F
H
PIY
Q
GK
S
GMSGERV
----
A
GKVIFETQSTHK
M
LAALSQAS
L
IH
I
----
KG
EY
D
EE
A
FNEA
F
MMHTTTSP
S
Y
P
IVAS
V
ETAAAM
L
R
GN
P
GKRLIN
R
S
V
ERA
L
H
FRKE
V
Q
---
RLR
E
E
---
SDGWFFD
I
WQP
PQ
VD
E
--------------------
A
ECWP
V
A
PGE
Q
WHGF
--
N
D
A
D
A
D
HM
F
LDP
V
KVTILTPGM
D
E
Q
G
N
MSE
E
GIPAALVAK
F
LDE
R
GIVVEKTGPYNLLFLFSIGIDKTKA
MG
LLR
G
LT
E
FKR
S
YDLNLR
I
KNMLP
D
LY
A
EDPDFY
R
NMRIQDLAQ
G
IHKLI
RK
H
D
LP
G
LM
L
RAF
DT
LP
E
M
I
MTP
HQ
A
W
Q
RQ
I
K
G
E
VE
T
I
A
LE
Q
LVGR
V
S
ANMILPYPPGVPLLMPGEM
L
T
K
ESR
T
VL
D
FL
L
MLCS
V
G
Q
HYPGFETDIHGA
KQDE
DG
V
Y
R
V
R
VLKMAG
fig|562.374.peg.2112
Escherichia coli 536A
MN
I
IAI
MGPH
GV
FY
K
D
EPI
K
EL
ES
AL
VA
Q
G
FQII
W
P
Q
N
S
V
DLLK
F
IE
H
N
P
RICGVIFDWD
E
Y
S
LDLC
S
D
I
N
QL
-------
NE
Y
LPLYAF
I
NT
H
ST
M
DVS
VQ
---
D
M
R
M
-----
A
L
C
FFEYALG
-
Q
AEDIA
I
R
MR
Q
Y
T
D
EY
LDN
I
T
PP
F
TKALF
T
YV
K
E
R
KYTFCTPGHMGGTA
Y
QKSPVG
C
LFYDFFG
G
NT
L
K
A
D
V
SISVTELGSLLDHTGPH
L
EAE
E
YIAR
T
FGA
EQ
SY
I
VTNGTSTSNKIVGMY
A
AP
S
GST
L
LIDRNCHKSL
A
HLLMM
N
DV
V
PV
W
LK
PTRNA
L
GILGGIP
RR
EF
T
RD
S
I
E
E
KV
A
A
T
T
-----
Q
AQWPVHAVITNSTYDGLLYNTD
W
IK
Q
TLDV
P
S
--
IHFDSAWVPYT
H
F
H
PIY
Q
GK
S
GMSGERV
----
A
GKVIFETQSTHK
M
LAALSQAS
L
IH
I
----
KG
EY
D
EE
A
FNEA
F
MMHTTTSP
S
Y
P
IVAS
V
ETAAAM
L
R
GN
P
GKRLIN
R
S
V
ERA
L
H
FRKE
V
Q
---
RLR
E
E
---
SDGWFFD
I
WQP
PQ
VD
E
--------------------
A
ECWP
V
A
PGE
Q
WHGF
--
N
D
A
D
A
D
HM
F
LDP
V
KVTILTPGM
D
E
Q
G
N
MSE
E
GIPAALVAK
F
LDE
R
GIVVEKTGPYNLLFLFSIGIDKTKA
MG
LLR
G
LT
E
FKR
S
YDLNLR
I
KNMLP
D
LY
A
EDPDFY
R
NMRIQDLAQ
G
IHKLI
RK
H
D
LP
G
LM
L
RAF
DT
LP
E
M
I
MTP
HQ
A
W
Q
RQ
I
K
G
E
VE
T
I
A
LE
Q
LVGR
V
S
ANMILPYPPGVPLLMPGEM
L
T
K
ESR
T
VL
D
FL
L
MLCS
V
G
Q
HYPGFETDIHGA
KQDE
DG
V
Y
R
V
R
VLKMAG
fig|83334.1.peg.276
Escherichia coli O157:H7
MN
I
IAI
MGPH
GV
FY
K
D
EPI
K
EL
ES
AL
VA
Q
G
FQII
W
P
Q
N
S
V
DLLK
F
IE
H
N
P
RICGVIFDWD
E
Y
S
LDLC
S
D
I
N
QL
-------
NE
Y
LPLYAF
I
NT
H
ST
M
DVS
VQ
---
D
M
R
M
-----
A
L
C
FFEYALG
-
Q
AEDIA
I
R
MR
Q
Y
T
D
EY
LDN
I
T
PP
F
TKALF
T
YV
K
E
R
KYTFCTPGHMGGTA
Y
QKSPVG
C
LFYDFFG
G
NT
L
K
A
D
V
SISVTELGSLLDHTGPH
L
EAE
E
YIAR
T
FGA
EQ
SY
I
VTNGTSTSNKIVGMY
A
AP
S
GST
L
LIDRNCHKSL
A
HLLMM
N
DV
V
PV
W
LK
PTRNA
L
GILGGIP
RR
EF
T
RD
S
I
E
E
KV
A
A
T
T
-----
Q
AQWPVHAVITNSTYDGLLYNTD
W
IK
Q
TLDV
P
S
--
IHFDSAWVPYT
H
F
H
PIY
Q
GK
S
GMSGERV
----
A
GKVIFETQSTHK
M
LAALSQAS
L
IH
I
----
KG
EY
D
EE
A
FNEA
F
MMHTTTSP
S
Y
P
IVAS
V
ETAAAM
L
R
GN
P
GKRLIN
R
S
V
ERA
L
H
FRKE
V
Q
---
RLR
E
E
---
SDGWFFD
I
WQP
PQ
VD
E
--------------------
A
ECWP
V
A
PGE
Q
WHGF
--
N
D
A
D
A
D
HM
F
LDP
V
KVTILTPGM
D
E
Q
G
N
MSE
E
GIPAALVAK
F
LDE
R
GIVVEKTGPYNLLFLFSIGIDKTKA
MG
LLR
G
LT
E
FKR
S
YDLNLR
I
KNMLP
D
LY
A
EDPDFY
R
NMRIQDLAQ
G
IHKLI
RK
H
D
LP
G
LM
L
RAF
DT
LP
E
M
I
MTP
HQ
A
W
Q
RQ
I
K
G
E
VE
T
I
A
LE
Q
LVGR
V
S
ANMILPYPPGVPLLMPGEM
L
T
K
ESR
T
VL
D
FL
L
MLCS
V
G
Q
HYPGFETDIHGA
KQDE
DG
V
Y
R
V
R
VLKMAG
fig|155864.1.peg.188
Escherichia coli O157:H7 EDL933
MN
I
IAI
MGPH
GV
FY
K
D
EPI
K
EL
ES
AL
VA
Q
G
FQII
W
P
Q
N
S
V
DLLK
F
IE
H
N
P
RICGVIFDWD
E
Y
S
LDLC
S
D
I
N
QL
-------
NE
Y
LPLYAF
I
NT
H
ST
M
DVS
VQ
---
D
M
R
M
-----
A
L
C
FFEYALG
-
Q
AEDIA
I
R
MR
Q
Y
T
D
EY
LDN
I
T
PP
F
TKALF
T
YV
K
E
R
KYTFCTPGHMGGTA
Y
QKSPVG
C
LFYDFFG
G
NT
L
K
A
D
V
SISVTELGSLLDHTGPH
L
EAE
E
YIAR
T
FGA
EQ
SY
I
VTNGTSTSNKIVGMY
A
AP
S
GST
L
LIDRNCHKSL
A
HLLMM
N
DV
V
PV
W
LK
PTRNA
L
GILGGIP
RR
EF
T
RD
S
I
E
E
KV
A
A
T
T
-----
Q
AQWPVHAVITNSTYDGLLYNTD
W
IK
Q
TLDV
P
S
--
IHFDSAWVPYT
H
F
H
PIY
Q
GK
S
GMSGERV
----
A
GKVIFETQSTHK
M
LAALSQAS
L
IH
I
----
KG
EY
D
EE
A
FNEA
F
MMHTTTSP
S
Y
P
IVAS
V
ETAAAM
L
R
GN
P
GKRLIN
R
S
V
ERA
L
H
FRKE
V
Q
---
RLR
E
E
---
SDGWFFD
I
WQP
PQ
VD
E
--------------------
A
ECWP
V
A
PGE
Q
WHGF
--
N
D
A
D
A
D
HM
F
LDP
V
KVTILTPGM
D
E
Q
G
N
MSE
E
GIPAALVAK
F
LDE
R
GIVVEKTGPYNLLFLFSIGIDKTKA
MG
LLR
G
LT
E
FKR
S
YDLNLR
I
KNMLP
D
LY
A
EDPDFY
R
NMRIQDLAQ
G
IHKLI
RK
H
D
LP
G
LM
L
RAF
DT
LP
E
M
I
MTP
HQ
A
W
Q
RQ
I
K
G
E
VE
T
I
A
LE
Q
LVGR
V
S
ANMILPYPPGVPLLMPGEM
L
T
K
ESR
T
VL
D
FL
L
MLCS
V
G
Q
HYPGFETDIHGA
KQDE
DG
V
Y
R
V
R
VLKMAG
fig|155864.8.peg.191
Escherichia coli O157:H7 EDL933
MN
I
IAI
MGPH
GV
FY
K
D
EPI
K
EL
ES
AL
VA
Q
G
FQII
W
P
Q
N
S
V
DLLK
F
IE
H
N
P
RICGVIFDWD
E
Y
S
LDLC
S
D
I
N
QL
-------
NE
Y
LPLYAF
I
NT
H
ST
M
DVS
VQ
---
D
M
R
M
-----
A
L
C
FFEYALG
-
Q
AEDIA
I
R
MR
Q
Y
T
D
EY
LDN
I
T
PP
F
TKALF
T
YV
K
E
R
KYTFCTPGHMGGTA
Y
QKSPVG
C
LFYDFFG
G
NT
L
K
A
D
V
SISVTELGSLLDHTGPH
L
EAE
E
YIAR
T
FGA
EQ
SY
I
VTNGTSTSNKIVGMY
A
AP
S
GST
L
LIDRNCHKSL
A
HLLMM
N
DV
V
PV
W
LK
PTRNA
L
GILGGIP
RR
EF
T
RD
S
I
E
E
KV
A
A
T
T
-----
Q
AQWPVHAVITNSTYDGLLYNTD
W
IK
Q
TLDV
P
S
--
IHFDSAWVPYT
H
F
H
PIY
Q
GK
S
GMSGERV
----
A
GKVIFETQSTHK
M
LAALSQAS
L
IH
I
----
KG
EY
D
EE
A
FNEA
F
MMHTTTSP
S
Y
P
IVAS
V
ETAAAM
L
R
GN
P
GKRLIN
R
S
V
ERA
L
H
FRKE
V
Q
---
RLR
E
E
---
SDGWFFD
I
WQP
PQ
VD
E
--------------------
A
ECWP
V
A
PGE
Q
WHGF
--
N
D
A
D
A
D
HM
F
LDP
V
KVTILTPGM
D
E
Q
G
N
MSE
E
GIPAALVAK
F
LDE
R
GIVVEKTGPYNLLFLFSIGIDKTKA
MG
LLR
G
LT
E
FKR
S
YDLNLR
I
KNMLP
D
LY
A
EDPDFY
R
NMRIQDLAQ
G
IHKLI
RK
H
D
LP
G
LM
L
RAF
DT
LP
E
M
I
MTP
HQ
A
W
Q
RQ
I
K
G
E
VE
T
I
A
LE
Q
LVGR
V
S
ANMILPYPPGVPLLMPGEM
L
T
K
ESR
T
VL
D
FL
L
MLCS
V
G
Q
HYPGFETDIHGA
KQDE
DG
V
Y
R
V
R
VLKMAG
fig|444454.5.peg.4653
Escherichia coli O157:H7 str. EC4024
MN
I
IAI
MGPH
GV
FY
K
D
EPI
K
EL
ES
AL
VA
Q
G
FQII
W
P
Q
N
S
V
DLLK
F
IE
H
N
P
RICGVIFDWD
E
Y
S
LDLC
S
D
I
N
QL
-------
NE
Y
LPLYAF
I
NT
H
ST
M
DVS
VQ
---
D
M
R
M
-----
A
L
C
FFEYALG
-
Q
AEDIA
I
R
MR
Q
Y
T
D
EY
LDN
I
T
PP
F
TKALF
T
YV
K
E
R
KYTFCTPGHMGGTA
Y
QKSPVG
C
LFYDFFG
G
NT
L
K
A
D
V
SISVTELGSLLDHTGPH
L
EAE
E
YIAR
T
FGA
EQ
SY
I
VTNGTSTSNKIVGMY
A
AP
S
GST
L
LIDRNCHKSL
A
HLLMM
N
DV
V
PV
W
LK
PTRNA
L
GILGGIP
RR
EF
T
RD
S
I
E
E
KV
A
A
T
T
-----
Q
AQWPVHAVITNSTYDGLLYNTD
W
IK
Q
TLDV
P
S
--
IHFDSAWVPYT
H
F
H
PIY
Q
GK
S
GMSGERV
----
A
GKVIFETQSTHK
M
LAALSQAS
L
IH
I
----
KG
EY
D
EE
A
FNEA
F
MMHTTTSP
S
Y
P
IVAS
V
ETAAAM
L
R
GN
P
GKRLIN
R
S
V
ERA
L
H
FRKE
V
Q
---
RLR
E
E
---
SDGWFFD
I
WQP
PQ
VD
E
--------------------
A
ECWP
V
A
PGE
Q
WHGF
--
N
D
A
D
A
D
HM
F
LDP
V
KVTILTPGM
D
E
Q
G
N
MSE
E
GIPAALVAK
F
LDE
R
GIVVEKTGPYNLLFLFSIGIDKTKA
MG
LLR
G
LT
E
FKR
S
YDLNLR
I
KNMLP
D
LY
A
EDPDFY
R
NMRIQDLAQ
G
IHKLI
RK
H
D
LP
G
LM
L
RAF
DT
LP
E
M
I
MTP
HQ
A
W
Q
RQ
I
K
G
E
VE
T
I
A
LE
Q
LVGR
V
S
ANMILPYPPGVPLLMPGEM
L
T
K
ESR
T
VL
D
FL
L
MLCS
V
G
Q
HYPGFETDIHGA
KQDE
DG
V
Y
R
V
R
VLKMAG
fig|444449.5.peg.4108
Escherichia coli O157:H7 str. EC4042
MN
I
IAI
MGPH
GV
FY
K
D
EPI
K
EL
ES
AL
VA
Q
G
FQII
W
P
Q
N
S
V
DLLK
F
IE
H
N
P
RICGVIFDWD
E
Y
S
LDLC
S
D
I
N
QL
-------
NE
Y
LPLYAF
I
NT
H
ST
M
DVS
VQ
---
D
M
R
M
-----
A
L
C
FFEYALG
-
Q
AEDIA
I
R
MR
Q
Y
T
D
EY
LDN
I
T
PP
F
TKALF
T
YV
K
E
R
KYTFCTPGHMGGTA
Y
QKSPVG
C
LFYDFFG
G
NT
L
K
A
D
V
SISVTELGSLLDHTGPH
L
EAE
E
YIAR
T
FGA
EQ
SY
I
VTNGTSTSNKIVGMY
A
AP
S
GST
L
LIDRNCHKSL
A
HLLMM
N
DV
V
PV
W
LK
PTRNA
L
GILGGIP
RR
EF
T
RD
S
I
E
E
KV
A
A
T
T
-----
Q
AQWPVHAVITNSTYDGLLYNTD
W
IK
Q
TLDV
P
S
--
IHFDSAWVPYT
H
F
H
PIY
Q
GK
S
GMSGERV
----
A
GKVIFETQSTHK
M
LAALSQAS
L
IH
I
----
KG
EY
D
EE
A
FNEA
F
MMHTTTSP
S
Y
P
IVAS
V
ETAAAM
L
R
GN
P
GKRLIN
R
S
V
ERA
L
H
FRKE
V
Q
---
RLR
E
E
---
SDGWFFD
I
WQP
PQ
VD
E
--------------------
A
ECWP
V
A
PGE
Q
WHGF
--
N
D
A
D
A
D
HM
F
LDP
V
KVTILTPGM
D
E
Q
G
N
MSE
E
GIPAALVAK
F
LDE
R
GIVVEKTGPYNLLFLFSIGIDKTKA
MG
LLR
G
LT
E
FKR
S
YDLNLR
I
KNMLP
D
LY
A
EDPDFY
R
NMRIQDLAQ
G
IHKLI
RK
H
D
LP
G
LM
L
RAF
DT
LP
E
M
I
MTP
HQ
A
W
Q
RQ
I
K
G
E
VE
T
I
A
LE
Q
LVGR
V
S
ANMILPYPPGVPLLMPGEM
L
T
K
ESR
T
VL
D
FL
L
MLCS
V
G
Q
HYPGFETDIHGA
KQDE
DG
V
Y
R
V
R
VLKMAG
fig|444448.5.peg.2863
Escherichia coli O157:H7 str. EC4045
MN
I
IAI
MGPH
GV
FY
K
D
EPI
K
EL
ES
AL
VA
Q
G
FQII
W
P
Q
N
S
V
DLLK
F
IE
H
N
P
RICGVIFDWD
E
Y
S
LDLC
S
D
I
N
QL
-------
NE
Y
LPLYAF
I
NT
H
ST
M
DVS
VQ
---
D
M
R
M
-----
A
L
C
FFEYALG
-
Q
AEDIA
I
R
MR
Q
Y
T
D
EY
LDN
I
T
PP
F
TKALF
T
YV
K
E
R
KYTFCTPGHMGGTA
Y
QKSPVG
C
LFYDFFG
G
NT
L
K
A
D
V
SISVTELGSLLDHTGPH
L
EAE
E
YIAR
T
FGA
EQ
SY
I
VTNGTSTSNKIVGMY
A
AP
S
GST
L
LIDRNCHKSL
A
HLLMM
N
DV
V
PV
W
LK
PTRNA
L
GILGGIP
RR
EF
T
RD
S
I
E
E
KV
A
A
T
T
-----
Q
AQWPVHAVITNSTYDGLLYNTD
W
IK
Q
TLDV
P
S
--
IHFDSAWVPYT
H
F
H
PIY
Q
GK
S
GMSGERV
----
A
GKVIFETQSTHK
M
LAALSQAS
L
IH
I
----
KG
EY
D
EE
A
FNEA
F
MMHTTTSP
S
Y
P
IVAS
V
ETAAAM
L
R
GN
P
GKRLIN
R
S
V
ERA
L
H
FRKE
V
Q
---
RLR
E
E
---
SDGWFFD
I
WQP
PQ
VD
E
--------------------
A
ECWP
V
A
PGE
Q
WHGF
--
N
D
A
D
A
D
HM
F
LDP
V
KVTILTPGM
D
E
Q
G
N
MSE
E
GIPAALVAK
F
LDE
R
GIVVEKTGPYNLLFLFSIGIDKTKA
MG
LLR
G
LT
E
FKR
S
YDLNLR
I
KNMLP
D
LY
A
EDPDFY
R
NMRIQDLAQ
G
IHKLI
RK
H
D
LP
G
LM
L
RAF
DT
LP
E
M
I
MTP
HQ
A
W
Q
RQ
I
K
G
E
VE
T
I
A
LE
Q
LVGR
V
S
ANMILPYPPGVPLLMPGEM
L
T
K
ESR
T
VL
D
FL
L
MLCS
V
G
Q
HYPGFETDIHGA
KQDE
DG
V
Y
R
V
R
VLKMAG
fig|444453.5.peg.3466
Escherichia coli O157:H7 str. EC4076
MN
I
IAI
MGPH
GV
FY
K
D
EPI
K
EL
ES
AL
VA
Q
G
FQII
W
P
Q
N
S
V
DLLK
F
IE
H
N
P
RICGVIFDWD
E
Y
S
LDLC
S
D
I
N
QL
-------
NE
Y
LPLYAF
I
NT
H
ST
M
DVS
VQ
---
D
M
R
M
-----
A
L
C
FFEYALG
-
Q
AEDIA
I
R
MR
Q
Y
T
D
EY
LDN
I
T
PP
F
TKALF
T
YV
K
E
R
KYTFCTPGHMGGTA
Y
QKSPVG
C
LFYDFFG
G
NT
L
K
A
D
V
SISVTELGSLLDHTGPH
L
EAE
E
YIAR
T
FGA
EQ
SY
I
VTNGTSTSNKIVGMY
A
AP
S
GST
L
LIDRNCHKSL
A
HLLMM
N
DV
V
PV
W
LK
PTRNA
L
GILGGIP
RR
EF
T
RD
S
I
E
E
KV
A
A
T
T
-----
Q
AQWPVHAVITNSTYDGLLYNTD
W
IK
Q
TLDV
P
S
--
IHFDSAWVPYT
H
F
H
PIY
Q
GK
S
GMSGERV
----
A
GKVIFETQSTHK
M
LAALSQAS
L
IH
I
----
KG
EY
D
EE
A
FNEA
F
MMHTTTSP
S
Y
P
IVAS
V
ETAAAM
L
R
GN
P
GKRLIN
R
S
V
ERA
L
H
FRKE
V
Q
---
RLR
E
E
---
SDGWFFD
I
WQP
PQ
VD
E
--------------------
A
ECWP
V
A
PGE
Q
WHGF
--
N
D
A
D
A
D
HM
F
LDP
V
KVTILTPGM
D
E
Q
G
N
MSE
E
GIPAALVAK
F
LDE
R
GIVVEKTGPYNLLFLFSIGIDKTKA
MG
LLR
G
LT
E
FKR
S
YDLNLR
I
KNMLP
D
LY
A
EDPDFY
R
NMRIQDLAQ
G
IHKLI
RK
H
D
LP
G
LM
L
RAF
DT
LP
E
M
I
MTP
HQ
A
W
Q
RQ
I
K
G
E
VE
T
I
A
LE
Q
LVGR
V
S
ANMILPYPPGVPLLMPGEM
L
T
K
ESR
T
VL
D
FL
L
MLCS
V
G
Q
HYPGFETDIHGA
KQDE
DG
V
Y
R
V
R
VLKMAG
fig|444452.5.peg.5034
Escherichia coli O157:H7 str. EC4113
MN
I
IAI
MGPH
GV
FY
K
D
EPI
K
EL
ES
AL
VA
Q
G
FQII
W
P
Q
N
S
V
DLLK
F
IE
H
N
P
RICGVIFDWD
E
Y
S
LDLC
S
D
I
N
QL
-------
NE
Y
LPLYAF
I
NT
H
ST
M
DVS
VQ
---
D
M
R
M
-----
A
L
C
FFEYALG
-
Q
AEDIA
I
R
MR
Q
Y
T
D
EY
LDN
I
T
PP
F
TKALF
T
YV
K
E
R
KYTFCTPGHMGGTA
Y
QKSPVG
C
LFYDFFG
G
NT
L
K
A
D
V
SISVTELGSLLDHTGPH
L
EAE
E
YIAR
T
FGA
EQ
SY
I
VTNGTSTSNKIVGMY
A
AP
S
GST
L
LIDRNCHKSL
A
HLLMM
N
DV
V
PV
W
LK
PTRNA
L
GILGGIP
RR
EF
T
RD
S
I
E
E
KV
A
A
T
T
-----
Q
AQWPVHAVITNSTYDGLLYNTD
W
IK
Q
TLDV
P
S
--
IHFDSAWVPYT
H
F
H
PIY
Q
GK
S
GMSGERV
----
A
GKVIFETQSTHK
M
LAALSQAS
L
IH
I
----
KG
EY
D
EE
A
FNEA
F
MMHTTTSP
S
Y
P
IVAS
V
ETAAAM
L
R
GN
P
GKRLIN
R
S
V
ERA
L
H
FRKE
V
Q
---
RLR
E
E
---
SDGWFFD
I
WQP
PQ
VD
E
--------------------
A
ECWP
V
A
PGE
Q
WHGF
--
N
D
A
D
A
D
HM
F
LDP
V
KVTILTPGM
D
E
Q
G
N
MSE
E
GIPAALVAK
F
LDE
R
GIVVEKTGPYNLLFLFSIGIDKTKA
MG
LLR
G
LT
E
FKR
S
YDLNLR
I
KNMLP
D
LY
A
EDPDFY
R
NMRIQDLAQ
G
IHKLI
RK
H
D
LP
G
LM
L
RAF
DT
LP
E
M
I
MTP
HQ
A
W
Q
RQ
I
K
G
E
VE
T
I
A
LE
Q
LVGR
V
S
ANMILPYPPGVPLLMPGEM
L
T
K
ESR
T
VL
D
FL
L
MLCS
V
G
Q
HYPGFETDIHGA
KQDE
DG
V
Y
R
V
R
VLKMAG
fig|444450.8.peg.332
Escherichia coli O157:H7 str. EC4115
MN
I
IAI
MGPH
GV
FY
K
D
EPI
K
EL
ES
AL
VA
Q
G
FQII
W
P
Q
N
S
V
DLLK
F
IE
H
N
P
RICGVIFDWD
E
Y
S
LDLC
S
D
I
N
QL
-------
NE
Y
LPLYAF
I
NT
H
ST
M
DVS
VQ
---
D
M
R
M
-----
A
L
C
FFEYALG
-
Q
AEDIA
I
R
MR
Q
Y
T
D
EY
LDN
I
T
PP
F
TKALF
T
YV
K
E
R
KYTFCTPGHMGGTA
Y
QKSPVG
C
LFYDFFG
G
NT
L
K
A
D
V
SISVTELGSLLDHTGPH
L
EAE
E
YIAR
T
FGA
EQ
SY
I
VTNGTSTSNKIVGMY
A
AP
S
GST
L
LIDRNCHKSL
A
HLLMM
N
DV
V
PV
W
LK
PTRNA
L
GILGGIP
RR
EF
T
RD
S
I
E
E
KV
A
A
T
T
-----
Q
AQWPVHAVITNSTYDGLLYNTD
W
IK
Q
TLDV
P
S
--
IHFDSAWVPYT
H
F
H
PIY
Q
GK
S
GMSGERV
----
A
GKVIFETQSTHK
M
LAALSQAS
L
IH
I
----
KG
EY
D
EE
A
FNEA
F
MMHTTTSP
S
Y
P
IVAS
V
ETAAAM
L
R
GN
P
GKRLIN
R
S
V
ERA
L
H
FRKE
V
Q
---
RLR
E
E
---
SDGWFFD
I
WQP
PQ
VD
E
--------------------
A
ECWP
V
A
PGE
Q
WHGF
--
N
D
A
D
A
D
HM
F
LDP
V
KVTILTPGM
D
E
Q
G
N
MSE
E
GIPAALVAK
F
LDE
R
GIVVEKTGPYNLLFLFSIGIDKTKA
MG
LLR
G
LT
E
FKR
S
YDLNLR
I
KNMLP
D
LY
A
EDPDFY
R
NMRIQDLAQ
G
IHKLI
RK
H
D
LP
G
LM
L
RAF
DT
LP
E
M
I
MTP
HQ
A
W
Q
RQ
I
K
G
E
VE
T
I
A
LE
Q
LVGR
V
S
ANMILPYPPGVPLLMPGEM
L
T
K
ESR
T
VL
D
FL
L
MLCS
V
G
Q
HYPGFETDIHGA
KQDE
DG
V
Y
R
V
R
VLKMAG
fig|444451.5.peg.5130
Escherichia coli O157:H7 str. EC4196
MN
I
IAI
MGPH
GV
FY
K
D
EPI
K
EL
ES
AL
VA
Q
G
FQII
W
P
Q
N
S
V
DLLK
F
IE
H
N
P
RICGVIFDWD
E
Y
S
LDLC
S
D
I
N
QL
-------
NE
Y
LPLYAF
I
NT
H
ST
M
DVS
VQ
---
D
M
R
M
-----
A
L
C
FFEYALG
-
Q
AEDIA
I
R
MR
Q
Y
T
D
EY
LDN
I
T
PP
F
TKALF
T
YV
K
E
R
KYTFCTPGHMGGTA
Y
QKSPVG
C
LFYDFFG
G
NT
L
K
A
D
V
SISVTELGSLLDHTGPH
L
EAE
E
YIAR
T
FGA
EQ
SY
I
VTNGTSTSNKIVGMY
A
AP
S
GST
L
LIDRNCHKSL
A
HLLMM
N
DV
V
PV
W
LK
PTRNA
L
GILGGIP
RR
EF
T
RD
S
I
E
E
KV
A
A
T
T
-----
Q
AQWPVHAVITNSTYDGLLYNTD
W
IK
Q
TLDV
P
S
--
IHFDSAWVPYT
H
F
H
PIY
Q
GK
S
GMSGERV
----
A
GKVIFETQSTHK
M
LAALSQAS
L
IH
I
----
KG
EY
D
EE
A
FNEA
F
MMHTTTSP
S
Y
P
IVAS
V
ETAAAM
L
R
GN
P
GKRLIN
R
S
V
ERA
L
H
FRKE
V
Q
---
RLR
E
E
---
SDGWFFD
I
WQP
PQ
VD
E
--------------------
A
ECWP
V
A
PGE
Q
WHGF
--
N
D
A
D
A
D
HM
F
LDP
V
KVTILTPGM
D
E
Q
G
N
MSE
E
GIPAALVAK
F
LDE
R
GIVVEKTGPYNLLFLFSIGIDKTKA
MG
LLR
G
LT
E
FKR
S
YDLNLR
I
KNMLP
D
LY
A
EDPDFY
R
NMRIQDLAQ
G
IHKLI
RK
H
D
LP
G
LM
L
RAF
DT
LP
E
M
I
MTP
HQ
A
W
Q
RQ
I
K
G
E
VE
T
I
A
LE
Q
LVGR
V
S
ANMILPYPPGVPLLMPGEM
L
T
K
ESR
T
VL
D
FL
L
MLCS
V
G
Q
HYPGFETDIHGA
KQDE
DG
V
Y
R
V
R
VLKMAG
fig|444447.5.peg.3038
Escherichia coli O157:H7 str. EC4206
MN
I
IAI
MGPH
GV
FY
K
D
EPI
K
EL
ES
AL
VA
Q
G
FQII
W
P
Q
N
S
V
DLLK
F
IE
H
N
P
RICGVIFDWD
E
Y
S
LDLC
S
D
I
N
QL
-------
NE
Y
LPLYAF
I
NT
H
ST
M
DVS
VQ
---
D
M
R
M
-----
A
L
C
FFEYALG
-
Q
AEDIA
I
R
MR
Q
Y
T
D
EY
LDN
I
T
PP
F
TKALF
T
YV
K
E
R
KYTFCTPGHMGGTA
Y
QKSPVG
C
LFYDFFG
G
NT
L
K
A
D
V
SISVTELGSLLDHTGPH
L
EAE
E
YIAR
T
FGA
EQ
SY
I
VTNGTSTSNKIVGMY
A
AP
S
GST
L
LIDRNCHKSL
A
HLLMM
N
DV
V
PV
W
LK
PTRNA
L
GILGGIP
RR
EF
T
RD
S
I
E
E
KV
A
A
T
T
-----
Q
AQWPVHAVITNSTYDGLLYNTD
W
IK
Q
TLDV
P
S
--
IHFDSAWVPYT
H
F
H
PIY
Q
GK
S
GMSGERV
----
A
GKVIFETQSTHK
M
LAALSQAS
L
IH
I
----
KG
EY
D
EE
A
FNEA
F
MMHTTTSP
S
Y
P
IVAS
V
ETAAAM
L
R
GN
P
GKRLIN
R
S
V
ERA
L
H
FRKE
V
Q
---
RLR
E
E
---
SDGWFFD
I
WQP
PQ
VD
E
--------------------
A
ECWP
V
A
PGE
Q
WHGF
--
N
D
A
D
A
D
HM
F
LDP
V
KVTILTPGM
D
E
Q
G
N
MSE
E
GIPAALVAK
F
LDE
R
GIVVEKTGPYNLLFLFSIGIDKTKA
MG
LLR
G
LT
E
FKR
S
YDLNLR
I
KNMLP
D
LY
A
EDPDFY
R
NMRIQDLAQ
G
IHKLI
RK
H
D
LP
G
LM
L
RAF
DT
LP
E
M
I
MTP
HQ
A
W
Q
RQ
I
K
G
E
VE
T
I
A
LE
Q
LVGR
V
S
ANMILPYPPGVPLLMPGEM
L
T
K
ESR
T
VL
D
FL
L
MLCS
V
G
Q
HYPGFETDIHGA
KQDE
DG
V
Y
R
V
R
VLKMAG
fig|478004.5.peg.5264
Escherichia coli O157:H7 str. EC4401
MN
I
IAI
MGPH
GV
FY
K
D
EPI
K
EL
ES
AL
VA
Q
G
FQII
W
P
Q
N
S
V
DLLK
F
IE
H
N
P
RICGVIFDWD
E
Y
S
LDLC
S
D
I
N
QL
-------
NE
Y
LPLYAF
I
NT
H
ST
M
DVS
VQ
---
D
M
R
M
-----
A
L
C
FFEYALG
-
Q
AEDIA
I
R
MR
Q
Y
T
D
EY
LDN
I
T
PP
F
TKALF
T
YV
K
E
R
KYTFCTPGHMGGTA
Y
QKSPVG
C
LFYDFFG
G
NT
L
K
A
D
V
SISVTELGSLLDHTGPH
L
EAE
E
YIAR
T
FGA
EQ
SY
I
VTNGTSTSNKIVGMY
A
AP
S
GST
L
LIDRNCHKSL
A
HLLMM
N
DV
V
PV
W
LK
PTRNA
L
GILGGIP
RR
EF
T
RD
S
I
E
E
KV
A
A
T
T
-----
Q
AQWPVHAVITNSTYDGLLYNTD
W
IK
Q
TLDV
P
S
--
IHFDSAWVPYT
H
F
H
PIY
Q
GK
S
GMSGERV
----
A
GKVIFETQSTHK
M
LAALSQAS
L
IH
I
----
KG
EY
D
EE
A
FNEA
F
MMHTTTSP
S
Y
P
IVAS
V
ETAAAM
L
R
GN
P
GKRLIN
R
S
V
ERA
L
H
FRKE
V
Q
---
RLR
E
E
---
SDGWFFD
I
WQP
PQ
VD
E
--------------------
A
ECWP
V
A
PGE
Q
WHGF
--
N
D
A
D
A
D
HM
F
LDP
V
KVTILTPGM
D
E
Q
G
N
MSE
E
GIPAALVAK
F
LDE
R
GIVVEKTGPYNLLFLFSIGIDKTKA
MG
LLR
G
LT
E
FKR
S
YDLNLR
I
KNMLP
D
LY
A
EDPDFY
R
NMRIQDLAQ
G
IHKLI
RK
H
D
LP
G
LM
L
RAF
DT
LP
E
M
I
MTP
HQ
A
W
Q
RQ
I
K
G
E
VE
T
I
A
LE
Q
LVGR
V
S
ANMILPYPPGVPLLMPGEM
L
T
K
ESR
T
VL
D
FL
L
MLCS
V
G
Q
HYPGFETDIHGA
KQDE
DG
V
Y
R
V
R
VLKMAG
fig|478005.5.peg.3797
Escherichia coli O157:H7 str. EC4486
MN
I
IAI
MGPH
GV
FY
K
D
EPI
K
EL
ES
AL
VA
Q
G
FQII
W
P
Q
N
S
V
DLLK
F
IE
H
N
P
RICGVIFDWD
E
Y
S
LDLC
S
D
I
N
QL
-------
NE
Y
LPLYAF
I
NT
H
ST
M
DVS
VQ
---
D
M
R
M
-----
A
L
C
FFEYALG
-
Q
AEDIA
I
R
MR
Q
Y
T
D
EY
LDN
I
T
PP
F
TKALF
T
YV
K
E
R
KYTFCTPGHMGGTA
Y
QKSPVG
C
LFYDFFG
G
NT
L
K
A
D
V
SISVTELGSLLDHTGPH
L
EAE
E
YIAR
T
FGA
EQ
SY
I
VTNGTSTSNKIVGMY
A
AP
S
GST
L
LIDRNCHKSL
A
HLLMM
N
DV
V
PV
W
LK
PTRNA
L
GILGGIP
RR
EF
T
RD
S
I
E
E
KV
A
A
T
T
-----
Q
AQWPVHAVITNSTYDGLLYNTD
W
IK
Q
TLDV
P
S
--
IHFDSAWVPYT
H
F
H
PIY
Q
GK
S
GMSGERV
----
A
GKVIFETQSTHK
M
LAALSQAS
L
IH
I
----
KG
EY
D
EE
A
FNEA
F
MMHTTTSP
S
Y
P
IVAS
V
ETAAAM
L
R
GN
P
GKRLIN
R
S
V
ERA
L
H
FRKE
V
Q
---
RLR
E
E
---
SDGWFFD
I
WQP
PQ
VD
E
--------------------
A
ECWP
V
A
PGE
Q
WHGF
--
N
D
A
D
A
D
HM
F
LDP
V
KVTILTPGM
D
E
Q
G
N
MSE
E
GIPAALVAK
F
LDE
R
GIVVEKTGPYNLLFLFSIGIDKTKA
MG
LLR
G
LT
E
FKR
S
YDLNLR
I
KNMLP
D
LY
A
EDPDFY
R
NMRIQDLAQ
G
IHKLI
RK
H
D
LP
G
LM
L
RAF
DT
LP
E
M
I
MTP
HQ
A
W
Q
RQ
I
K
G
E
VE
T
I
A
LE
Q
LVGR
V
S
ANMILPYPPGVPLLMPGEM
L
T
K
ESR
T
VL
D
FL
L
MLCS
V
G
Q
HYPGFETDIHGA
KQDE
DG
V
Y
R
V
R
VLKMAG
fig|478006.5.peg.5217
Escherichia coli O157:H7 str. EC4501
MN
I
IAI
MGPH
GV
FY
K
D
EPI
K
EL
ES
AL
VA
Q
G
FQII
W
P
Q
N
S
V
DLLK
F
IE
H
N
P
RICGVIFDWD
E
Y
S
LDLC
S
D
I
N
QL
-------
NE
Y
LPLYAF
I
NT
H
ST
M
DVS
VQ
---
D
M
R
M
-----
A
L
C
FFEYALG
-
Q
AEDIA
I
R
MR
Q
Y
T
D
EY
LDN
I
T
PP
F
TKALF
T
YV
K
E
R
KYTFCTPGHMGGTA
Y
QKSPVG
C
LFYDFFG
G
NT
L
K
A
D
V
SISVTELGSLLDHTGPH
L
EAE
E
YIAR
T
FGA
EQ
SY
I
VTNGTSTSNKIVGMY
A
AP
S
GST
L
LIDRNCHKSL
A
HLLMM
N
DV
V
PV
W
LK
PTRNA
L
GILGGIP
RR
EF
T
RD
S
I
E
E
KV
A
A
T
T
-----
Q
AQWPVHAVITNSTYDGLLYNTD
W
IK
Q
TLDV
P
S
--
IHFDSAWVPYT
H
F
H
PIY
Q
GK
S
GMSGERV
----
A
GKVIFETQSTHK
M
LAALSQAS
L
IH
I
----
KG
EY
D
EE
A
FNEA
F
MMHTTTSP
S
Y
P
IVAS
V
ETAAAM
L
R
GN
P
GKRLIN
R
S
V
ERA
L
H
FRKE
V
Q
---
RLR
E
E
---
SDGWFFD
I
WQP
PQ
VD
E
--------------------
A
ECWP
V
A
PGE
Q
WHGF
--
N
D
A
D
A
D
HM
F
LDP
V
KVTILTPGM
D
E
Q
G
N
MSE
E
GIPAALVAK
F
LDE
R
GIVVEKTGPYNLLFLFSIGIDKTKA
MG
LLR
G
LT
E
FKR
S
YDLNLR
I
KNMLP
D
LY
A
EDPDFY
R
NMRIQDLAQ
G
IHKLI
RK
H
D
LP
G
LM
L
RAF
DT
LP
E
M
I
MTP
HQ
A
W
Q
RQ
I
K
G
E
VE
T
I
A
LE
Q
LVGR
V
S
ANMILPYPPGVPLLMPGEM
L
T
K
ESR
T
VL
D
FL
L
MLCS
V
G
Q
HYPGFETDIHGA
KQDE
DG
V
Y
R
V
R
VLKMAG
fig|478008.5.peg.4383
Escherichia coli O157:H7 str. EC869
MN
I
IAI
MGPH
GV
FY
K
D
EPI
K
EL
ES
AL
VA
Q
G
FQII
W
P
Q
N
S
V
DLLK
F
IE
H
N
P
RICGVIFDWD
E
Y
S
LDLC
S
D
I
N
QL
-------
NE
Y
LPLYAF
I
NT
H
ST
M
DVS
VQ
---
D
M
R
M
-----
A
L
C
FFEYALG
-
Q
AEDIA
I
R
MR
Q
Y
T
D
EY
LDN
I
T
PP
F
TKALF
T
YV
K
E
R
KYTFCTPGHMGGTA
Y
QKSPVG
C
LFYDFFG
G
NT
L
K
A
D
V
SISVTELGSLLDHTGPH
L
EAE
E
YIAR
T
FGA
EQ
SY
I
VTNGTSTSNKIVGMY
A
AP
S
GST
L
LIDRNCHKSL
A
HLLMM
N
DV
V
PV
W
LK
PTRNA
L
GILGGIP
RR
EF
T
RD
S
I
E
E
KV
A
A
T
T
-----
Q
AQWPVHAVITNSTYDGLLYNTD
W
IK
Q
TLDV
P
S
--
IHFDSAWVPYT
H
F
H
PIY
Q
GK
S
GMSGERV
----
A
GKVIFETQSTHK
M
LAALSQAS
L
IH
I
----
KG
EY
D
EE
A
FNEA
F
MMHTTTSP
S
Y
P
IVAS
V
ETAAAM
L
R
GN
P
GKRLIN
R
S
V
ERA
L
H
FRKE
V
Q
---
RLR
E
E
---
SDGWFFD
I
WQP
PQ
VD
E
--------------------
A
ECWP
V
A
PGE
Q
WHGF
--
N
D
A
D
A
D
HM
F
LDP
V
KVTILTPGM
D
E
Q
G
N
MSE
E
GIPAALVAK
F
LDE
R
GIVVEKTGPYNLLFLFSIGIDKTKA
MG
LLR
G
LT
E
FKR
S
YDLNLR
I
KNMLP
D
LY
A
EDPDFY
R
NMRIQDLAQ
G
IHKLI
RK
H
D
LP
G
LM
L
RAF
DT
LP
E
M
I
MTP
HQ
A
W
Q
RQ
I
K
G
E
VE
T
I
A
LE
Q
LVGR
V
S
ANMILPYPPGVPLLMPGEM
L
T
K
ESR
T
VL
D
FL
L
MLCS
V
G
Q
HYPGFETDIHGA
KQDE
DG
V
Y
R
V
R
VLKMAG
fig|637388.3.peg.4029
Escherichia coli O157:H7 str. FRIK2000
MN
I
IAI
MGPH
GV
FY
K
D
EPI
K
EL
ES
AL
VA
Q
G
FQII
W
P
Q
N
S
V
DLLK
F
IE
H
N
P
RICGVIFDWD
E
Y
S
LDLC
S
D
I
N
QL
-------
NE
Y
LPLYAF
I
NT
H
ST
M
DVS
VQ
---
D
M
R
M
-----
A
L
C
FFEYALG
-
Q
AEDIA
I
R
MR
Q
Y
T
D
EY
LDN
I
T
PP
F
TKALF
T
YV
K
E
R
KYTFCTPGHMGGTA
Y
QKSPVG
C
LFYDFFG
G
NT
L
K
A
D
V
SISVTELGSLLDHTGPH
L
EAE
E
YIAR
T
FGA
EQ
SY
I
VTNGTSTSNKIVGMY
A
AP
S
GST
L
LIDRNCHKSL
A
HLLMM
N
DV
V
PV
W
LK
PTRNA
L
GILGGIP
RR
EF
T
RD
S
I
E
E
KV
A
A
T
T
-----
Q
AQWPVHAVITNSTYDGLLYNTD
W
IK
Q
TLDV
P
S
--
IHFDSAWVPYT
H
F
H
PIY
Q
GK
S
GMSGERV
----
A
GKVIFETQSTHK
M
LAALSQAS
L
IH
I
----
KG
EY
D
EE
A
FNEA
F
MMHTTTSP
S
Y
P
IVAS
V
ETAAAM
L
R
GN
P
GKRLIN
R
S
V
ERA
L
H
FRKE
V
Q
---
RLR
E
E
---
SDGWFFD
I
WQP
PQ
VD
E
--------------------
A
ECWP
V
A
PGE
Q
WHGF
--
N
D
A
D
A
D
HM
F
LDP
V
KVTILTPGM
D
E
Q
G
N
MSE
E
GIPAALVAK
F
LDE
R
GIVVEKTGPYNLLFLFSIGIDKTKA
MG
LLR
G
LT
E
FKR
S
YDLNLR
I
KNMLP
D
LY
A
EDPDFY
R
NMRIQDLAQ
G
IHKLI
RK
H
D
LP
G
LM
L
RAF
DT
LP
E
M
I
MTP
HQ
A
W
Q
RQ
I
K
G
E
VE
T
I
A
LE
Q
LVGR
V
S
ANMILPYPPGVPLLMPGEM
L
T
K
ESR
T
VL
D
FL
L
MLCS
V
G
Q
HYPGFETDIHGA
KQDE
DG
V
Y
R
V
R
VLKMAG
fig|570506.3.peg.1193
Escherichia coli O157:H7 str. FRIK966
MN
I
IAI
MGPH
GV
FY
K
D
EPI
K
EL
ES
AL
VA
Q
G
FQII
W
P
Q
N
S
V
DLLK
F
IE
H
N
P
RICGVIFDWD
E
Y
S
LDLC
S
D
I
N
QL
-------
NE
Y
LPLYAF
I
NT
H
ST
M
DVS
VQ
---
D
M
R
M
-----
A
L
C
FFEYALG
-
Q
AEDIA
I
R
MR
Q
Y
T
D
EY
LDN
I
T
PP
F
TKALF
T
YV
K
E
R
KYTFCTPGHMGGTA
Y
QKSPVG
C
LFYDFFG
G
NT
L
K
A
D
V
SISVTELGSLLDHTGPH
L
EAE
E
YIAR
T
FGA
EQ
SY
I
VTNGTSTSNKIVGMY
A
AP
S
GST
L
LIDRNCHKSL
A
HLLMM
N
DV
V
PV
W
LK
PTRNA
L
GILGGIP
RR
EF
T
RD
S
I
E
E
KV
A
A
T
T
-----
Q
AQWPVHAVITNSTYDGLLYNTD
W
IK
Q
TLDV
P
S
--
IHFDSAWVPYT
H
F
H
PIY
Q
GK
S
GMSGERV
----
A
GKVIFETQSTHK
M
LAALSQAS
L
IH
I
----
KG
EY
D
EE
A
FNEA
F
MMHTTTSP
S
Y
P
IVAS
V
ETAAAM
L
R
GN
P
GKRLIN
R
S
V
ERA
L
H
FRKE
V
Q
---
RLR
E
E
---
SDGWFFD
I
WQP
PQ
VD
E
--------------------
A
ECWP
V
A
PGE
Q
WHGF
--
N
D
A
D
A
D
HM
F
LDP
V
KVTILTPGM
D
E
Q
G
N
MSE
E
GIPAALVAK
F
LDE
R
GIVVEKTGPYNLLFLFSIGIDKTKA
MG
LLR
G
LT
E
FKR
S
YDLNLR
I
KNMLP
D
LY
A
EDPDFY
R
NMRIQDLAQ
G
IHKLI
RK
H
D
LP
G
LM
L
RAF
DT
LP
E
M
I
MTP
HQ
A
W
Q
RQ
I
K
G
E
VE
T
I
A
LE
Q
LVGR
V
S
ANMILPYPPGVPLLMPGEM
L
T
K
ESR
T
VL
D
FL
L
MLCS
V
G
Q
HYPGFETDIHGA
KQDE
DG
V
Y
R
V
R
VLKMAG
fig|386585.9.peg.291
Escherichia coli O157:H7 str. Sakai
MN
I
IAI
MGPH
GV
FY
K
D
EPI
K
EL
ES
AL
VA
Q
G
FQII
W
P
Q
N
S
V
DLLK
F
IE
H
N
P
RICGVIFDWD
E
Y
S
LDLC
S
D
I
N
QL
-------
NE
Y
LPLYAF
I
NT
H
ST
M
DVS
VQ
---
D
M
R
M
-----
A
L
C
FFEYALG
-
Q
AEDIA
I
R
MR
Q
Y
T
D
EY
LDN
I
T
PP
F
TKALF
T
YV
K
E
R
KYTFCTPGHMGGTA
Y
QKSPVG
C
LFYDFFG
G
NT
L
K
A
D
V
SISVTELGSLLDHTGPH
L
EAE
E
YIAR
T
FGA
EQ
SY
I
VTNGTSTSNKIVGMY
A
AP
S
GST
L
LIDRNCHKSL
A
HLLMM
N
DV
V
PV
W
LK
PTRNA
L
GILGGIP
RR
EF
T
RD
S
I
E
E
KV
A
A
T
T
-----
Q
AQWPVHAVITNSTYDGLLYNTD
W
IK
Q
TLDV
P
S
--
IHFDSAWVPYT
H
F
H
PIY
Q
GK
S
GMSGERV
----
A
GKVIFETQSTHK
M
LAALSQAS
L
IH
I
----
KG
EY
D
EE
A
FNEA
F
MMHTTTSP
S
Y
P
IVAS
V
ETAAAM
L
R
GN
P
GKRLIN
R
S
V
ERA
L
H
FRKE
V
Q
---
RLR
E
E
---
SDGWFFD
I
WQP
PQ
VD
E
--------------------
A
ECWP
V
A
PGE
Q
WHGF
--
N
D
A
D
A
D
HM
F
LDP
V
KVTILTPGM
D
E
Q
G
N
MSE
E
GIPAALVAK
F
LDE
R
GIVVEKTGPYNLLFLFSIGIDKTKA
MG
LLR
G
LT
E
FKR
S
YDLNLR
I
KNMLP
D
LY
A
EDPDFY
R
NMRIQDLAQ
G
IHKLI
RK
H
D
LP
G
LM
L
RAF
DT
LP
E
M
I
MTP
HQ
A
W
Q
RQ
I
K
G
E
VE
T
I
A
LE
Q
LVGR
V
S
ANMILPYPPGVPLLMPGEM
L
T
K
ESR
T
VL
D
FL
L
MLCS
V
G
Q
HYPGFETDIHGA
KQDE
DG
V
Y
R
V
R
VLKMAG
fig|544404.4.peg.194
Escherichia coli O157:H7 str. TW14359
MN
I
IAI
MGPH
GV
FY
K
D
EPI
K
EL
ES
AL
VA
Q
G
FQII
W
P
Q
N
S
V
DLLK
F
IE
H
N
P
RICGVIFDWD
E
Y
S
LDLC
S
D
I
N
QL
-------
NE
Y
LPLYAF
I
NT
H
ST
M
DVS
VQ
---
D
M
R
M
-----
A
L
C
FFEYALG
-
Q
AEDIA
I
R
MR
Q
Y
T
D
EY
LDN
I
T
PP
F
TKALF
T
YV
K
E
R
KYTFCTPGHMGGTA
Y
QKSPVG
C
LFYDFFG
G
NT
L
K
A
D
V
SISVTELGSLLDHTGPH
L
EAE
E
YIAR
T
FGA
EQ
SY
I
VTNGTSTSNKIVGMY
A
AP
S
GST
L
LIDRNCHKSL
A
HLLMM
N
DV
V
PV
W
LK
PTRNA
L
GILGGIP
RR
EF
T
RD
S
I
E
E
KV
A
A
T
T
-----
Q
AQWPVHAVITNSTYDGLLYNTD
W
IK
Q
TLDV
P
S
--
IHFDSAWVPYT
H
F
H
PIY
Q
GK
S
GMSGERV
----
A
GKVIFETQSTHK
M
LAALSQAS
L
IH
I
----
KG
EY
D
EE
A
FNEA
F
MMHTTTSP
S
Y
P
IVAS
V
ETAAAM
L
R
GN
P
GKRLIN
R
S
V
ERA
L
H
FRKE
V
Q
---
RLR
E
E
---
SDGWFFD
I
WQP
PQ
VD
E
--------------------
A
ECWP
V
A
PGE
Q
WHGF
--
N
D
A
D
A
D
HM
F
LDP
V
KVTILTPGM
D
E
Q
G
N
MSE
E
GIPAALVAK
F
LDE
R
GIVVEKTGPYNLLFLFSIGIDKTKA
MG
LLR
G
LT
E
FKR
S
YDLNLR
I
KNMLP
D
LY
A
EDPDFY
R
NMRIQDLAQ
G
IHKLI
RK
H
D
LP
G
LM
L
RAF
DT
LP
E
M
I
MTP
HQ
A
W
Q
RQ
I
K
G
E
VE
T
I
A
LE
Q
LVGR
V
S
ANMILPYPPGVPLLMPGEM
L
T
K
ESR
T
VL
D
FL
L
MLCS
V
G
Q
HYPGFETDIHGA
KQDE
DG
V
Y
R
V
R
VLKMAG
fig|502346.5.peg.1072
Escherichia coli O157:H7 str. TW14588
MN
I
IAI
MGPH
GV
FY
K
D
EPI
K
EL
ES
AL
VA
Q
G
FQII
W
P
Q
N
S
V
DLLK
F
IE
H
N
P
RICGVIFDWD
E
Y
S
LDLC
S
D
I
N
QL
-------
NE
Y
LPLYAF
I
NT
H
ST
M
DVS
VQ
---
D
M
R
M
-----
A
L
C
FFEYALG
-
Q
AEDIA
I
R
MR
Q
Y
T
D
EY
LDN
I
T
PP
F
TKALF
T
YV
K
E
R
KYTFCTPGHMGGTA
Y
QKSPVG
C
LFYDFFG
G
NT
L
K
A
D
V
SISVTELGSLLDHTGPH
L
EAE
E
YIAR
T
FGA
EQ
SY
I
VTNGTSTSNKIVGMY
A
AP
S
GST
L
LIDRNCHKSL
A
HLLMM
N
DV
V
PV
W
LK
PTRNA
L
GILGGIP
RR
EF
T
RD
S
I
E
E
KV
A
A
T
T
-----
Q
AQWPVHAVITNSTYDGLLYNTD
W
IK
Q
TLDV
P
S
--
IHFDSAWVPYT
H
F
H
PIY
Q
GK
S
GMSGERV
----
A
GKVIFETQSTHK
M
LAALSQAS
L
IH
I
----
KG
EY
D
EE
A
FNEA
F
MMHTTTSP
S
Y
P
IVAS
V
ETAAAM
L
R
GN
P
GKRLIN
R
S
V
ERA
L
H
FRKE
V
Q
---
RLR
E
E
---
SDGWFFD
I
WQP
PQ
VD
E
--------------------
A
ECWP
V
A
PGE
Q
WHGF
--
N
D
A
D
A
D
HM
F
LDP
V
KVTILTPGM
D
E
Q
G
N
MSE
E
GIPAALVAK
F
LDE
R
GIVVEKTGPYNLLFLFSIGIDKTKA
MG
LLR
G
LT
E
FKR
S
YDLNLR
I
KNMLP
D
LY
A
EDPDFY
R
NMRIQDLAQ
G
IHKLI
RK
H
D
LP
G
LM
L
RAF
DT
LP
E
M
I
MTP
HQ
A
W
Q
RQ
I
K
G
E
VE
T
I
A
LE
Q
LVGR
V
S
ANMILPYPPGVPLLMPGEM
L
T
K
ESR
T
VL
D
FL
L
MLCS
V
G
Q
HYPGFETDIHGA
KQDE
DG
V
Y
R
V
R
VLKMAG
fig|701177.3.peg.193
Escherichia coli O55:H7 str. CB9615
MN
I
IAI
MGPH
GV
FY
K
D
EPI
K
EL
ES
AL
VA
Q
G
FQII
W
P
Q
N
S
V
DLLK
F
IE
H
N
P
RICGVIFDWD
E
Y
S
LDLC
S
D
I
N
QL
-------
NE
Y
LPLYAF
I
NT
H
ST
M
DVS
VQ
---
D
M
R
M
-----
A
L
C
FFEYALG
-
Q
AEDIA
I
R
MR
Q
Y
T
D
EY
LDN
I
T
PP
F
TKALF
T
YV
K
E
R
KYTFCTPGHMGGTA
Y
QKSPVG
C
LFYDFFG
G
NT
L
K
A
D
V
SISVTELGSLLDHTGPH
L
EAE
E
YIAR
T
FGA
EQ
SY
I
VTNGTSTSNKIVGMY
A
AP
S
GST
L
LIDRNCHKSL
A
HLLMM
N
DV
V
PV
W
LK
PTRNA
L
GILGGIP
RR
EF
T
RD
S
I
E
E
KV
A
A
T
T
-----
Q
AQWPVHAVITNSTYDGLLYNTD
W
IK
Q
TLDV
P
S
--
IHFDSAWVPYT
H
F
H
PIY
Q
GK
S
GMSGERV
----
A
GKVIFETQSTHK
M
LAALSQAS
L
IH
I
----
KG
EY
D
EE
A
FNEA
F
MMHTTTSP
S
Y
P
IVAS
V
ETAAAM
L
R
GN
P
GKRLIN
R
S
V
ERA
L
H
FRKE
V
Q
---
RLR
E
E
---
SDGWFFD
I
WQP
PQ
VD
E
--------------------
A
ECWP
V
A
PGE
Q
WHGF
--
N
D
A
D
A
D
HM
F
LDP
V
KVTILTPGM
D
E
Q
G
N
MSE
E
GIPAALVAK
F
LDE
R
GIVVEKTGPYNLLFLFSIGIDKTKA
MG
LLR
G
LT
E
FKR
S
YDLNLR
I
KNMLP
D
LY
A
EDPDFY
R
NMRIQDLAQ
G
IHKLI
RK
H
D
LP
G
LM
L
RAF
DT
LP
E
M
I
MTP
HQ
A
W
Q
RQ
I
K
G
E
VE
T
I
A
LE
Q
LVGR
V
S
ANMILPYPPGVPLLMPGEM
L
T
K
ESR
T
VL
D
FL
L
MLCS
V
G
Q
HYPGFETDIHGA
KQDE
DG
V
Y
R
V
R
VLKMAG
fig|550677.3.peg.576
Escherichia coli B354
MN
I
IAI
MGPH
GV
FY
K
D
EPI
K
EL
ES
AL
VA
Q
G
FQII
W
P
Q
N
S
V
DLLK
F
IE
H
N
P
RICGVIFDWD
E
Y
S
LDLC
S
D
I
N
QL
-------
NE
Y
LPLYAF
I
NT
H
ST
M
DVS
VQ
---
D
M
R
M
-----
A
L
W
FFEYALG
-
Q
AEDIA
I
R
MR
Q
Y
T
D
EY
LDN
I
T
PP
F
TKALF
T
YV
K
E
R
KYTFCTPGHMGGTA
Y
QKSPVG
C
LFYDFFG
G
NT
L
K
A
D
V
SISVTELGSLLDHTGPH
L
EAE
E
YIAR
T
F
D
A
EQ
SY
I
VTNGTSTSNKIVGMY
A
AP
S
GST
L
LIDRNCHKSL
A
HLLMM
N
DV
V
PV
W
LK
PTRNA
L
GILGGIP
RR
EF
S
RD
S
I
E
E
KV
A
A
T
T
-----
Q
AQWPVHAVITNSTYDGLLYNTD
W
IK
Q
TLDV
P
S
--
IHFDSAWVPYT
H
F
H
PIY
Q
GK
S
GMSGERV
----
A
GKVIFETQSTHK
M
LAALSQAS
L
IH
I
----
KG
EY
D
EE
A
FNEA
F
MMHTTTSP
S
Y
P
IVAS
V
ETAAAM
L
R
GN
P
GKRLIN
R
S
V
ERA
L
H
FRKE
V
Q
---
RLR
E
E
---
SDGWFFD
I
WQP
PQ
VD
E
--------------------
A
ECWP
V
A
PGE
Q
WHGF
--
N
D
A
D
A
D
HM
F
LDP
V
KVTILTPGM
D
E
Q
G
N
MS
D
E
GIPAALVAK
F
LDE
R
GIVVEKTGPYNLLFLFSIGIDKTKA
MG
LLR
G
LT
E
FKR
S
YDLNLR
I
KNMLP
D
LY
A
EDPDFY
R
NMRIQDLAQ
G
IHKLI
RK
H
D
LP
G
LM
L
RAF
DT
LP
E
M
I
MTP
HQ
A
W
Q
RQ
I
K
G
E
VE
T
I
A
LE
Q
LVGR
V
S
ANMILPYPPGVPLLMPGEM
L
T
K
ESR
T
VL
D
FL
L
MLCS
V
G
Q
HYPGFETDIHGA
KQDE
DG
V
Y
R
V
R
VLKMAG
fig|749549.3.peg.4539
Escherichia coli MS 198-1
MN
I
IAI
MGPH
GV
FY
K
D
EPI
K
EL
ES
AL
VG
Q
G
FQII
W
P
Q
N
S
V
DLLK
F
IE
H
N
P
RICGVIFDWD
E
Y
S
LDLC
S
D
I
N
QL
-------
NE
Y
LPLYAF
I
NT
H
ST
M
DVS
VQ
---
D
M
R
M
-----
A
L
W
FFEYALG
-
Q
AEDIA
I
R
MR
Q
Y
T
D
EY
LDN
I
T
PP
F
TKALF
T
YV
K
E
R
KYTFCTPGHMGGTA
Y
QKSPVG
C
LFYDFFG
G
NT
L
K
A
D
V
SISVTELGSLLDHTGPH
L
EAE
E
YIAR
T
F
D
A
EQ
SY
I
VTNGTSTSNKIVGMY
A
AP
S
GST
L
LIDRNCHKSL
A
HLLMM
N
DV
V
PV
W
LK
PTRNA
L
GILGGIP
RR
EF
S
RD
S
I
E
E
KV
A
A
T
T
-----
Q
AQWPVHAVITNSTYDGLLYNTD
W
IK
Q
TLDV
P
S
--
IHFDSAWVPYT
H
F
H
PIY
Q
GK
S
GMSGERV
----
A
GKVIFETQSTHK
M
LAALSQAS
L
IH
I
----
KG
EY
D
EE
A
FNEA
F
MMHTTTSP
S
Y
P
IVAS
V
ETAAAM
L
R
GN
P
GKRLIN
R
S
V
ERA
L
H
FRKE
V
Q
---
RLR
E
E
---
SDGWFFD
I
WQP
PQ
VD
E
--------------------
A
ECWP
V
A
PGE
Q
WHGF
--
N
D
A
D
A
D
HM
F
LDP
V
KVTILTPGM
D
E
Q
G
N
MSE
E
GIPAALVAK
F
LDE
R
GIVVEKTGPYNLLFLFSIGIDKTKA
MG
LLR
G
LT
E
FKR
S
YDLNLR
I
KNMLP
D
LY
A
EDPDFY
R
NMRIQDLAQ
G
IHKLI
RK
H
D
LP
G
LM
L
RAF
DT
LP
E
M
I
MTP
HQ
A
W
Q
RQ
I
K
G
E
VE
T
I
A
LE
Q
LVGR
V
S
ANMILPYPPGVPLLMPGEM
L
T
K
ESR
T
VL
D
FL
L
MLCS
V
G
Q
HYPGFETDIHGA
KQDE
DG
V
Y
R
V
R
VLKMAG
fig|749527.3.peg.3157
Escherichia coli MS 21-1
MN
I
IAI
MGPH
GV
FY
K
D
EPI
K
EL
ES
AL
VA
Q
G
FQII
W
P
Q
N
S
V
DLLK
F
IE
H
N
P
RICGVIFDWD
E
Y
S
LDLC
S
D
I
N
QL
-------
NE
Y
LPLYAF
I
NT
H
ST
M
DVS
VQ
---
D
M
R
M
-----
A
L
W
FFEYALG
-
Q
AEDIA
I
R
MR
Q
Y
T
N
EY
LDN
I
T
PP
F
TKALF
T
YV
K
E
R
KYTFCTPGHMGGTA
Y
QKSPVG
C
LFYDFFG
G
NT
L
K
A
D
V
SISVTELGSLLDHTGPH
L
EAE
E
YIAR
T
FGA
EQ
SY
I
VTNGTSTSNKIVGMY
A
AP
S
GST
L
LIDRNCHKSL
A
HLLMM
N
DV
V
PV
W
LK
PTRNA
L
GILGGIP
RR
EF
T
RD
S
I
E
E
KV
A
A
T
T
-----
Q
AQWPVHAVITNSTYDGLLYNTD
W
IK
Q
TLDV
P
S
--
IHFDSAWVPYT
H
F
H
PIY
Q
GK
S
GMSGERV
----
A
GKVIFETQSTHK
M
LAALSQAS
L
IH
I
----
KG
EY
D
EE
A
FNEA
F
MMHTTTSP
S
Y
P
IVAS
V
ETAAAM
L
R
GN
P
GKRLIN
R
S
V
ERA
L
H
FRKE
V
Q
---
RLR
E
E
---
SDGWFFD
I
WQP
PQ
VD
E
--------------------
A
ECWP
V
A
PGE
Q
WHGF
--
N
D
A
D
A
D
HM
F
LDP
V
KVTILTPGM
D
E
Q
G
N
MSE
E
GIPAALVAK
F
LDE
R
GIVVEKTGPYNLLFLFSIGIDKTKA
MG
LLR
G
LT
E
FKR
S
YDLNLR
I
KNMLP
D
LY
A
EDPDFY
R
S
MRIQDLAQ
G
IHKLI
RK
H
D
LP
G
LM
L
RAF
DT
LP
E
M
I
MTP
HQ
A
W
Q
RQ
I
K
G
E
VE
T
I
A
LE
Q
LVGR
V
S
ANMILPYPPGVPLLMPGEM
L
TEESR
T
VL
D
FL
L
MLCS
V
G
Q
HYPGFETDIHGA
KQDE
DG
I
Y
R
V
R
VLKMAG
fig|550676.3.peg.4871
Escherichia coli B185
MN
I
IAI
MGPH
GV
FY
K
D
EPI
K
EL
ES
AL
VA
Q
G
FQII
W
P
Q
N
S
V
DLLK
F
IE
H
N
P
RICGVIFDWD
E
Y
S
LDLC
S
D
I
N
QL
-------
NE
Y
LPLYAF
I
NT
H
ST
M
DVS
VQ
---
D
M
R
M
-----
A
L
W
FFEYALG
-
Q
AEDIA
I
R
MR
Q
Y
T
N
EY
LDN
I
T
PP
F
TKALF
T
YV
K
E
R
KYTFCTPGHMGGTA
Y
QKSPVG
C
LFYDFFG
G
NT
L
K
A
D
V
SISVTELGSLLDHTGPH
L
EAE
E
YIAR
T
FGA
EQ
SY
I
VTNGTSTSNKIVGMY
A
AP
S
GST
L
LIDRNCHKSL
A
HLLMM
N
DV
V
PV
W
LK
PTRNA
L
GILGGIP
RR
EF
T
RD
S
I
E
E
KV
A
A
T
T
-----
Q
AQWPVHAVITNSTYDGLLYNTD
W
IK
Q
TLDV
P
S
--
IHFDSAWVPYT
H
F
H
PIY
Q
GK
S
GMSGERV
----
A
GKVIFETQSTHK
M
LAALSQAS
L
IH
I
----
KG
EY
D
EE
A
FNEA
F
MMHTTTSP
S
Y
P
IVAS
V
ETAAAM
L
R
GN
P
GKRLIN
R
S
V
ERA
L
H
FRKE
V
Q
---
RLR
E
E
---
SDGWFF
Y
I
WQP
PQ
VD
E
--------------------
A
ECWP
V
A
PGE
E
WHGF
--
N
D
A
D
A
D
HM
F
LDP
V
KVTILTPGM
D
E
Q
G
N
MSE
E
GIPAALVAK
F
LDE
R
GIVVEKTGPYNLLFLFSIGIDKTKA
MG
LLR
G
LT
E
FKR
S
YDLNLR
I
KNMLP
D
LY
A
EDPDFY
R
NMRIQDLAQ
G
IHKLI
RK
H
D
LP
G
LM
L
RAF
DT
LP
E
M
I
MTP
HQ
A
W
Q
RQ
I
K
G
E
VE
T
I
A
LE
Q
LVGR
V
S
ANMILPYPPGVPLLMPGEM
L
T
K
ESR
T
VL
D
FL
L
MLCS
V
G
Q
HYPGFETDIHGA
KQDE
DG
V
Y
R
V
R
VLKMAG
fig|439855.10.peg.372
Escherichia coli SMS-3-5
MN
I
IAI
MGPH
GV
FY
K
D
EPI
K
EL
ES
AL
VA
Q
G
FQII
W
P
Q
N
S
V
DLLK
F
IE
H
N
P
RICGVIFDWD
E
Y
S
LDLC
S
D
I
N
QL
-------
NE
Y
LPLYAF
I
NT
H
ST
M
DVS
VQ
---
D
M
R
M
-----
A
L
W
FFEYALG
-
Q
AEDIA
I
R
MR
Q
Y
T
N
EY
LDN
I
T
PP
F
TKALF
T
YV
K
E
R
KYTFCTPGHMGGTA
Y
QKSPVG
C
LFYDFFG
G
NT
L
K
A
D
V
SISVTELGSLLDHTGPH
L
EAE
E
YIAR
T
FGA
EQ
SY
I
VTNGTSTSNKIVGMY
A
AP
S
GST
L
LIDRNCHKSL
A
HLLMM
N
DV
V
PV
W
LK
PTRNA
L
GILGGIP
RR
EF
S
RD
S
I
E
E
KV
A
A
T
T
-----
Q
AQWPVHAVITNSTYDGLLYNTD
W
IK
Q
TLDV
P
S
--
IHFDSAWVPYT
H
F
H
PIY
Q
GK
S
GMSGERV
----
A
GKVIFETQSTHK
M
LAALSQAS
L
IH
I
----
KG
EY
D
EE
A
FNEA
F
MMHTTTSP
S
Y
P
IVAS
V
ETAAAM
L
R
GN
P
GKRLIN
R
S
V
ERA
L
H
FRKE
V
Q
---
RLR
E
E
---
SDGWFFD
I
WQP
PQ
VD
E
--------------------
A
ECWP
V
A
PGE
Q
WHGF
--
N
D
A
D
A
D
HM
F
LDP
V
KVTILTPGM
D
E
Q
G
N
MSE
E
GIPAALVAK
F
LDE
R
GIVVEKTGPYNLLFLFSIGIDKTKA
MG
LLR
G
LT
E
FKR
S
YDLNLR
I
KNMLP
D
LY
A
EDPDFY
R
S
MRIQDLAQ
G
IHKLI
RK
H
D
LP
G
LM
L
RAF
DT
LP
E
M
I
MTP
HQ
A
W
Q
RQ
I
K
G
E
VE
T
I
A
LE
Q
LVGR
V
S
ANMILPYPPGVPLLMPGEM
L
TEESR
T
VL
D
FL
L
MLCS
V
G
Q
HYPGFETDIHGA
KQDE
DG
I
Y
R
V
R
VLKMAG
fig|362663.8.peg.199
Escherichia coli 536
MN
I
IAI
MGPH
GV
FY
K
D
EPI
K
EL
ES
AL
VA
Q
G
FQII
W
P
Q
N
S
V
DLLK
F
IE
H
N
P
RICGVIFDWD
E
Y
S
LDLC
S
D
I
N
QL
-------
NE
Y
LPLYAF
I
NT
H
ST
M
DVS
VQ
---
D
M
R
M
-----
A
L
W
FFEYALG
-
Q
AEDIA
I
R
MR
Q
Y
T
N
EY
LDN
I
T
PP
F
TKALF
T
YV
K
E
R
KYTFCTPGHMGGTA
Y
QKSPVG
C
LFYDFFG
G
NT
L
K
A
D
V
SISVTELGSLLDHTGPH
L
EAE
E
YIAR
T
FGA
EQ
SY
I
VTNGTSTSNKIVGMY
A
AP
F
GST
L
LIDRNCHKSL
A
HLLMM
N
DV
V
PV
W
LK
PTRNA
L
GILGGIP
RR
EF
T
RD
S
I
E
E
KV
A
A
T
T
-----
Q
AQWPVHAVITNSTYDGLLYNTD
W
IK
Q
TLDV
P
S
--
IHFDSAWVPYT
H
F
H
PIY
Q
GK
S
GMSGERV
----
A
GKVIFETQSTHK
M
LAALSQAS
L
IH
I
----
KG
EY
D
EE
A
FNEA
F
MMHTTTSP
S
Y
P
IVAS
V
ETAAAM
L
R
GN
P
GKRLIN
R
S
V
ERA
L
H
FRKE
V
Q
---
RLR
E
E
---
SDGWFFD
I
WQP
PQ
VD
E
--------------------
A
ECWP
V
A
PGE
Q
WHGF
--
S
D
A
D
A
N
HM
F
LDP
V
KVTILTPGM
D
E
Q
G
N
MSE
E
GIPAALVAK
F
LDE
R
GIVVEKTGPYNLLFLFSIGIDKTKA
MG
LLR
G
LT
E
FKR
S
YDLNLR
I
KNMLP
D
LY
A
EDPDFY
R
NMRIQDLAQ
G
IHKLI
RK
H
D
LP
G
LM
L
RAF
DT
LP
E
M
I
MTP
HQ
A
W
Q
RQ
I
K
G
E
VE
T
I
A
LE
Q
LVGR
V
S
ANMILPYPPGVPLLMPGEM
L
TEESR
T
VL
D
FL
L
MLCS
V
G
Q
HYPGFETDIHGA
KQDE
DG
V
Y
R
V
R
VLKMAG
fig|362663.9.peg.199
Escherichia coli 536
MN
I
IAI
MGPH
GV
FY
K
D
EPI
K
EL
ES
AL
VA
Q
G
FQII
W
P
Q
N
S
V
DLLK
F
IE
H
N
P
RICGVIFDWD
E
Y
S
LDLC
S
D
I
N
QL
-------
NE
Y
LPLYAF
I
NT
H
ST
M
DVS
VQ
---
D
M
R
M
-----
A
L
W
FFEYALG
-
Q
AEDIA
I
R
MR
Q
Y
T
N
EY
LDN
I
T
PP
F
TKALF
T
YV
K
E
R
KYTFCTPGHMGGTA
Y
QKSPVG
C
LFYDFFG
G
NT
L
K
A
D
V
SISVTELGSLLDHTGPH
L
EAE
E
YIAR
T
FGA
EQ
SY
I
VTNGTSTSNKIVGMY
A
AP
F
GST
L
LIDRNCHKSL
A
HLLMM
N
DV
V
PV
W
LK
PTRNA
L
GILGGIP
RR
EF
T
RD
S
I
E
E
KV
A
A
T
T
-----
Q
AQWPVHAVITNSTYDGLLYNTD
W
IK
Q
TLDV
P
S
--
IHFDSAWVPYT
H
F
H
PIY
Q
GK
S
GMSGERV
----
A
GKVIFETQSTHK
M
LAALSQAS
L
IH
I
----
KG
EY
D
EE
A
FNEA
F
MMHTTTSP
S
Y
P
IVAS
V
ETAAAM
L
R
GN
P
GKRLIN
R
S
V
ERA
L
H
FRKE
V
Q
---
RLR
E
E
---
SDGWFFD
I
WQP
PQ
VD
E
--------------------
A
ECWP
V
A
PGE
Q
WHGF
--
S
D
A
D
A
N
HM
F
LDP
V
KVTILTPGM
D
E
Q
G
N
MSE
E
GIPAALVAK
F
LDE
R
GIVVEKTGPYNLLFLFSIGIDKTKA
MG
LLR
G
LT
E
FKR
S
YDLNLR
I
KNMLP
D
LY
A
EDPDFY
R
NMRIQDLAQ
G
IHKLI
RK
H
D
LP
G
LM
L
RAF
DT
LP
E
M
I
MTP
HQ
A
W
Q
RQ
I
K
G
E
VE
T
I
A
LE
Q
LVGR
V
S
ANMILPYPPGVPLLMPGEM
L
TEESR
T
VL
D
FL
L
MLCS
V
G
Q
HYPGFETDIHGA
KQDE
DG
V
Y
R
V
R
VLKMAG
fig|340197.3.peg.2869
Escherichia coli F11
MN
I
IAI
MGPH
GV
FY
K
D
EPI
K
EL
ES
AL
VA
Q
G
FQII
W
P
Q
N
S
V
DLLK
F
IE
H
N
P
RICGVIFDWD
E
Y
S
LDLC
S
D
I
N
QL
-------
NE
Y
LPLYAF
I
NT
H
ST
M
DVS
VQ
---
D
M
R
M
-----
A
L
W
FFEYALG
-
Q
AEDIA
I
R
MR
Q
Y
T
N
EY
LDN
I
T
PP
F
TKALF
T
YV
K
E
R
KYTFCTPGHMGGTA
Y
QKSPVG
C
LFYDFFG
G
NT
L
K
A
D
V
SISVTELGSLLDHTGPH
L
EAE
E
YIAR
T
FGA
EQ
SY
I
VTNGTSTSNKIVGMY
A
AP
F
GST
L
LIDRNCHKSL
A
HLLMM
N
DV
V
PV
W
LK
PTRNA
L
GILGGIP
RR
EF
T
RD
S
I
E
E
KV
A
A
T
T
-----
Q
AQWPVHAVITNSTYDGLLYNTD
W
IK
Q
TLDV
P
S
--
IHFDSAWVPYT
H
F
H
PIY
Q
GK
S
GMSGERV
----
A
GKVIFETQSTHK
M
LAALSQAS
L
IH
I
----
KG
EY
D
EE
A
FNEA
F
MMHTTTSP
S
Y
P
IVAS
V
ETAAAM
L
R
GN
P
GKRLIN
R
S
V
ERA
L
H
FRKE
V
Q
---
RLR
E
E
---
SDGWFFD
I
WQP
PQ
VD
E
--------------------
A
ECWP
V
A
PGE
Q
WHGF
--
S
D
A
D
A
N
HM
F
LDP
V
KVTILTPGM
D
E
Q
G
N
MSE
E
GIPAALVAK
F
LDE
R
GIVVEKTGPYNLLFLFSIGIDKTKA
MG
LLR
G
LT
E
FKR
S
YDLNLR
I
KNMLP
D
LY
A
EDPDFY
R
NMRIQDLAQ
G
IHKLI
RK
H
D
LP
G
LM
L
RAF
DT
LP
E
M
I
MTP
HQ
A
W
Q
RQ
I
K
G
E
VE
T
I
A
LE
Q
LVGR
V
S
ANMILPYPPGVPLLMPGEM
L
TEESR
T
VL
D
FL
L
MLCS
V
G
Q
HYPGFETDIHGA
KQDE
DG
V
Y
R
V
R
VLKMAG
fig|340197.5.peg.2999
Escherichia coli F11
MN
I
IAI
MGPH
GV
FY
K
D
EPI
K
EL
ES
AL
VA
Q
G
FQII
W
P
Q
N
S
V
DLLK
F
IE
H
N
P
RICGVIFDWD
E
Y
S
LDLC
S
D
I
N
QL
-------
NE
Y
LPLYAF
I
NT
H
ST
M
DVS
VQ
---
D
M
R
M
-----
A
L
W
FFEYALG
-
Q
AEDIA
I
R
MR
Q
Y
T
N
EY
LDN
I
T
PP
F
TKALF
T
YV
K
E
R
KYTFCTPGHMGGTA
Y
QKSPVG
C
LFYDFFG
G
NT
L
K
A
D
V
SISVTELGSLLDHTGPH
L
EAE
E
YIAR
T
FGA
EQ
SY
I
VTNGTSTSNKIVGMY
A
AP
F
GST
L
LIDRNCHKSL
A
HLLMM
N
DV
V
PV
W
LK
PTRNA
L
GILGGIP
RR
EF
T
RD
S
I
E
E
KV
A
A
T
T
-----
Q
AQWPVHAVITNSTYDGLLYNTD
W
IK
Q
TLDV
P
S
--
IHFDSAWVPYT
H
F
H
PIY
Q
GK
S
GMSGERV
----
A
GKVIFETQSTHK
M
LAALSQAS
L
IH
I
----
KG
EY
D
EE
A
FNEA
F
MMHTTTSP
S
Y
P
IVAS
V
ETAAAM
L
R
GN
P
GKRLIN
R
S
V
ERA
L
H
FRKE
V
Q
---
RLR
E
E
---
SDGWFFD
I
WQP
PQ
VD
E
--------------------
A
ECWP
V
A
PGE
Q
WHGF
--
S
D
A
D
A
N
HM
F
LDP
V
KVTILTPGM
D
E
Q
G
N
MSE
E
GIPAALVAK
F
LDE
R
GIVVEKTGPYNLLFLFSIGIDKTKA
MG
LLR
G
LT
E
FKR
S
YDLNLR
I
KNMLP
D
LY
A
EDPDFY
R
NMRIQDLAQ
G
IHKLI
RK
H
D
LP
G
LM
L
RAF
DT
LP
E
M
I
MTP
HQ
A
W
Q
RQ
I
K
G
E
VE
T
I
A
LE
Q
LVGR
V
S
ANMILPYPPGVPLLMPGEM
L
TEESR
T
VL
D
FL
L
MLCS
V
G
Q
HYPGFETDIHGA
KQDE
DG
V
Y
R
V
R
VLKMAG
fig|656393.3.peg.805
Escherichia coli H299
MN
I
IAI
MGPH
GV
FY
K
D
EPI
K
EL
ES
AL
VA
Q
G
FQII
W
P
Q
N
S
V
DLLK
F
IE
H
N
P
RICGVIFDWD
E
Y
S
LDLC
S
D
I
N
QL
-------
NE
Y
LPLYAF
I
NT
H
ST
M
DVS
VQ
---
D
M
R
M
-----
A
L
W
FFEYALG
-
Q
AEDIA
I
R
MR
Q
Y
T
N
EY
LDN
I
T
PP
F
TKALF
T
YV
K
E
R
KYTFCTPGHMGGTA
Y
QKSPVG
C
LFYDFFG
G
NT
L
K
A
D
V
SISVTELGSLLDHTGPH
L
EAE
E
YIAR
T
FGA
EQ
SY
I
VTNGTSTSNKIVGMY
A
AP
F
GST
L
LIDRNCHKSL
A
HLLMM
N
DV
V
PV
W
LK
PTRNA
L
GILGGIP
RR
EF
T
RD
S
I
E
E
KV
A
A
T
T
-----
Q
AQWPVHAVITNSTYDGLLYNTD
W
IK
Q
TLDV
P
S
--
IHFDSAWVPYT
H
F
H
PIY
Q
GK
S
GMSGERV
----
A
GKVIFETQSTHK
M
LAALSQAS
L
IH
I
----
KG
EY
D
EE
A
FNEA
F
MMHTTTSP
S
Y
P
IVAS
V
ETAAAM
L
R
GN
P
GKRLIN
R
S
V
ERA
L
H
FRKE
V
Q
---
RLR
E
E
---
SDGWFFD
I
WQP
PQ
VD
E
--------------------
A
ECWP
V
A
PGE
Q
WHGF
--
S
D
A
D
A
N
HM
F
LDP
V
KVTILTPGM
D
E
Q
G
N
MSE
E
GIPAALVAK
F
LDE
R
GIVVEKTGPYNLLFLFSIGIDKTKA
MG
LLR
G
LT
E
FKR
S
YDLNLR
I
KNMLP
D
LY
A
EDPDFY
R
NMRIQDLAQ
G
IHKLI
RK
H
D
LP
G
LM
L
RAF
DT
LP
E
M
I
MTP
HQ
A
W
Q
RQ
I
K
G
E
VE
T
I
A
LE
Q
LVGR
V
S
ANMILPYPPGVPLLMPGEM
L
TEESR
T
VL
D
FL
L
MLCS
V
G
Q
HYPGFETDIHGA
KQDE
DG
V
Y
R
V
R
VLKMAG
fig|749550.3.peg.3478
Escherichia coli MS 200-1
MN
I
IAI
MGPH
GV
FY
K
D
EPI
K
EL
ES
AL
VA
Q
G
FQII
W
P
Q
N
S
V
DLLK
F
IE
H
N
P
RICGVIFDWD
E
Y
S
LDLC
S
D
I
N
QL
-------
NE
Y
LPLYAF
I
NT
H
ST
M
DVS
VQ
---
D
M
R
M
-----
A
L
W
FFEYALG
-
Q
AEDIA
I
R
MR
Q
Y
T
N
EY
LDN
I
T
PP
F
TKALF
T
YV
K
E
R
KYTFCTPGHMGGTA
Y
QKSPVG
C
LFYDFFG
G
NT
L
K
A
D
V
SISVTELGSLLDHTGPH
L
EAE
E
YIAR
T
FGA
EQ
SY
I
VTNGTSTSNKIVGMY
A
AP
F
GST
L
LIDRNCHKSL
A
HLLMM
N
DV
V
PV
W
LK
PTRNA
L
GILGGIP
RR
EF
T
RD
S
I
E
E
KV
A
A
T
T
-----
Q
AQWPVHAVITNSTYDGLLYNTD
W
IK
Q
TLDV
P
S
--
IHFDSAWVPYT
H
F
H
PIY
Q
GK
S
GMSGERV
----
A
GKVIFETQSTHK
M
LAALSQAS
L
IH
I
----
KG
EY
D
EE
A
FNEA
F
MMHTTTSP
S
Y
P
IVAS
V
ETAAAM
L
R
GN
P
GKRLIN
R
S
V
ERA
L
H
FRKE
V
Q
---
RLR
E
E
---
SDGWFFD
I
WQP
PQ
VD
E
--------------------
A
ECWP
V
A
PGE
Q
WHGF
--
S
D
A
D
A
N
HM
F
LDP
V
KVTILTPGM
D
E
Q
G
N
MSE
E
GIPAALVAK
F
LDE
R
GIVVEKTGPYNLLFLFSIGIDKTKA
MG
LLR
G
LT
E
FKR
S
YDLNLR
I
KNMLP
D
LY
A
EDPDFY
R
NMRIQDLAQ
G
IHKLI
RK
H
D
LP
G
LM
L
RAF
DT
LP
E
M
I
MTP
HQ
A
W
Q
RQ
I
K
G
E
VE
T
I
A
LE
Q
LVGR
V
S
ANMILPYPPGVPLLMPGEM
L
TEESR
T
VL
D
FL
L
MLCS
V
G
Q
HYPGFETDIHGA
KQDE
DG
V
Y
R
V
R
VLKMAG
fig|525281.3.peg.1076
Escherichia coli 83972
MN
I
IAI
MGPH
GV
FY
K
D
EPI
K
EL
ES
AL
VA
Q
G
FQII
W
P
Q
N
S
V
DLLK
F
IE
H
N
P
RICGVIFDWD
E
Y
S
LDLC
S
D
I
N
QL
-------
NE
Y
LPLYAF
I
NT
H
ST
M
DVS
VQ
---
D
M
R
M
-----
A
L
W
FFEYALG
-
Q
AEDIA
I
R
MR
Q
Y
T
N
EY
LDN
I
T
PP
F
TKALF
T
YV
K
E
R
KYTFCTPGHMGGTA
Y
QKSPVG
C
LFYDFFG
G
NT
L
K
A
D
V
SISVTELGSLLDHTGPH
L
EAE
E
YIAR
T
FGA
EQ
SY
I
VTNGTSTSNKIVGMY
A
AP
S
GST
L
LIDRNCHKSL
A
HLLMM
N
DV
V
PV
W
LK
PTRNA
L
GILGGIP
RG
EF
T
RD
S
I
E
E
KV
A
A
T
T
-----
Q
AQWPVHAVITNSTYDGLLYNTD
W
IK
Q
TLDV
P
S
--
IHFDSAWVPYT
H
F
H
PIY
Q
GK
S
GMSGERV
----
A
GKVIFETQSTHK
M
LAALSQAS
L
IH
I
----
KG
EY
D
EE
A
FNEA
F
MMHTTTSP
S
Y
P
IVAS
V
ETAAAM
L
R
GN
P
GKRLIN
R
S
V
ERA
L
H
FRKE
V
Q
---
RLR
E
E
---
SDGWFFD
I
WQP
PQ
VD
E
--------------------
A
ECWP
V
A
PGE
Q
WHGF
--
S
D
A
D
A
N
HM
F
LDP
V
KVTILTPGM
D
E
Q
G
N
MSE
E
GIPAALVAK
F
LDE
R
GIVVEKTGPYNLLFLFSIGIDKTKA
MG
LLR
G
LT
E
FKR
S
YDLNLR
I
KNMLP
D
LY
A
EDPDFY
R
NMRIQDLAQ
G
IHKLI
RK
H
D
LP
G
LM
L
RAF
DT
LP
E
M
I
MTP
HQ
A
W
Q
RQ
I
K
G
E
VE
T
I
A
LE
Q
LVGR
V
S
ANMILPYPPGVPLLMPGEM
L
TEESR
T
VL
D
FL
L
MLCS
V
G
Q
HYPGFETDIHGA
KQDE
DG
V
Y
R
V
R
VLKMAG
fig|655817.3.peg.213
Escherichia coli ABU 83972
MN
I
IAI
MGPH
GV
FY
K
D
EPI
K
EL
ES
AL
VA
Q
G
FQII
W
P
Q
N
S
V
DLLK
F
IE
H
N
P
RICGVIFDWD
E
Y
S
LDLC
S
D
I
N
QL
-------
NE
Y
LPLYAF
I
NT
H
ST
M
DVS
VQ
---
D
M
R
M
-----
A
L
W
FFEYALG
-
Q
AEDIA
I
R
MR
Q
Y
T
N
EY
LDN
I
T
PP
F
TKALF
T
YV
K
E
R
KYTFCTPGHMGGTA
Y
QKSPVG
C
LFYDFFG
G
NT
L
K
A
D
V
SISVTELGSLLDHTGPH
L
EAE
E
YIAR
T
FGA
EQ
SY
I
VTNGTSTSNKIVGMY
A
AP
S
GST
L
LIDRNCHKSL
A
HLLMM
N
DV
V
PV
W
LK
PTRNA
L
GILGGIP
RG
EF
T
RD
S
I
E
E
KV
A
A
T
T
-----
Q
AQWPVHAVITNSTYDGLLYNTD
W
IK
Q
TLDV
P
S
--
IHFDSAWVPYT
H
F
H
PIY
Q
GK
S
GMSGERV
----
A
GKVIFETQSTHK
M
LAALSQAS
L
IH
I
----
KG
EY
D
EE
A
FNEA
F
MMHTTTSP
S
Y
P
IVAS
V
ETAAAM
L
R
GN
P
GKRLIN
R
S
V
ERA
L
H
FRKE
V
Q
---
RLR
E
E
---
SDGWFFD
I
WQP
PQ
VD
E
--------------------
A
ECWP
V
A
PGE
Q
WHGF
--
S
D
A
D
A
N
HM
F
LDP
V
KVTILTPGM
D
E
Q
G
N
MSE
E
GIPAALVAK
F
LDE
R
GIVVEKTGPYNLLFLFSIGIDKTKA
MG
LLR
G
LT
E
FKR
S
YDLNLR
I
KNMLP
D
LY
A
EDPDFY
R
NMRIQDLAQ
G
IHKLI
RK
H
D
LP
G
LM
L
RAF
DT
LP
E
M
I
MTP
HQ
A
W
Q
RQ
I
K
G
E
VE
T
I
A
LE
Q
LVGR
V
S
ANMILPYPPGVPLLMPGEM
L
TEESR
T
VL
D
FL
L
MLCS
V
G
Q
HYPGFETDIHGA
KQDE
DG
V
Y
R
V
R
VLKMAG
fig|199310.1.peg.216
Escherichia coli CFT073
MN
I
IAI
MGPH
GV
FY
K
D
EPI
K
EL
ES
AL
VA
Q
G
FQII
W
P
Q
N
S
V
DLLK
F
IE
H
N
P
RICGVIFDWD
E
Y
S
LDLC
S
D
I
N
QL
-------
NE
Y
LPLYAF
I
NT
H
ST
M
DVS
VQ
---
D
M
R
M
-----
A
L
W
FFEYALG
-
Q
AEDIA
I
R
MR
Q
Y
T
N
EY
LDN
I
T
PP
F
TKALF
T
YV
K
E
R
KYTFCTPGHMGGTA
Y
QKSPVG
C
LFYDFFG
G
NT
L
K
A
D
V
SISVTELGSLLDHTGPH
L
EAE
E
YIAR
T
FGA
EQ
SY
I
VTNGTSTSNKIVGMY
A
AP
S
GST
L
LIDRNCHKSL
A
HLLMM
N
DV
V
PV
W
LK
PTRNA
L
GILGGIP
RG
EF
T
RD
S
I
E
E
KV
A
A
T
T
-----
Q
AQWPVHAVITNSTYDGLLYNTD
W
IK
Q
TLDV
P
S
--
IHFDSAWVPYT
H
F
H
PIY
Q
GK
S
GMSGERV
----
A
GKVIFETQSTHK
M
LAALSQAS
L
IH
I
----
KG
EY
D
EE
A
FNEA
F
MMHTTTSP
S
Y
P
IVAS
V
ETAAAM
L
R
GN
P
GKRLIN
R
S
V
ERA
L
H
FRKE
V
Q
---
RLR
E
E
---
SDGWFFD
I
WQP
PQ
VD
E
--------------------
A
ECWP
V
A
PGE
Q
WHGF
--
S
D
A
D
A
N
HM
F
LDP
V
KVTILTPGM
D
E
Q
G
N
MSE
E
GIPAALVAK
F
LDE
R
GIVVEKTGPYNLLFLFSIGIDKTKA
MG
LLR
G
LT
E
FKR
S
YDLNLR
I
KNMLP
D
LY
A
EDPDFY
R
NMRIQDLAQ
G
IHKLI
RK
H
D
LP
G
LM
L
RAF
DT
LP
E
M
I
MTP
HQ
A
W
Q
RQ
I
K
G
E
VE
T
I
A
LE
Q
LVGR
V
S
ANMILPYPPGVPLLMPGEM
L
TEESR
T
VL
D
FL
L
MLCS
V
G
Q
HYPGFETDIHGA
KQDE
DG
V
Y
R
V
R
VLKMAG
fig|199310.4.peg.211
Escherichia coli CFT073
MN
I
IAI
MGPH
GV
FY
K
D
EPI
K
EL
ES
AL
VA
Q
G
FQII
W
P
Q
N
S
V
DLLK
F
IE
H
N
P
RICGVIFDWD
E
Y
S
LDLC
S
D
I
N
QL
-------
NE
Y
LPLYAF
I
NT
H
ST
M
DVS
VQ
---
D
M
R
M
-----
A
L
W
FFEYALG
-
Q
AEDIA
I
R
MR
Q
Y
T
N
EY
LDN
I
T
PP
F
TKALF
T
YV
K
E
R
KYTFCTPGHMGGTA
Y
QKSPVG
C
LFYDFFG
G
NT
L
K
A
D
V
SISVTELGSLLDHTGPH
L
EAE
E
YIAR
T
FGA
EQ
SY
I
VTNGTSTSNKIVGMY
A
AP
S
GST
L
LIDRNCHKSL
A
HLLMM
N
DV
V
PV
W
LK
PTRNA
L
GILGGIP
RG
EF
T
RD
S
I
E
E
KV
A
A
T
T
-----
Q
AQWPVHAVITNSTYDGLLYNTD
W
IK
Q
TLDV
P
S
--
IHFDSAWVPYT
H
F
H
PIY
Q
GK
S
GMSGERV
----
A
GKVIFETQSTHK
M
LAALSQAS
L
IH
I
----
KG
EY
D
EE
A
FNEA
F
MMHTTTSP
S
Y
P
IVAS
V
ETAAAM
L
R
GN
P
GKRLIN
R
S
V
ERA
L
H
FRKE
V
Q
---
RLR
E
E
---
SDGWFFD
I
WQP
PQ
VD
E
--------------------
A
ECWP
V
A
PGE
Q
WHGF
--
S
D
A
D
A
N
HM
F
LDP
V
KVTILTPGM
D
E
Q
G
N
MSE
E
GIPAALVAK
F
LDE
R
GIVVEKTGPYNLLFLFSIGIDKTKA
MG
LLR
G
LT
E
FKR
S
YDLNLR
I
KNMLP
D
LY
A
EDPDFY
R
NMRIQDLAQ
G
IHKLI
RK
H
D
LP
G
LM
L
RAF
DT
LP
E
M
I
MTP
HQ
A
W
Q
RQ
I
K
G
E
VE
T
I
A
LE
Q
LVGR
V
S
ANMILPYPPGVPLLMPGEM
L
TEESR
T
VL
D
FL
L
MLCS
V
G
Q
HYPGFETDIHGA
KQDE
DG
V
Y
R
V
R
VLKMAG
fig|749546.3.peg.3665
Escherichia coli MS 185-1
MN
I
IAI
MGPH
GV
FY
K
D
EPI
K
EL
ES
AL
VA
Q
G
FQII
W
P
Q
N
S
V
DLLK
F
IE
H
N
P
RICGVIFDWD
E
Y
S
LDLC
S
D
I
N
QL
-------
NE
Y
LPLYAF
I
NT
H
ST
M
DVS
VQ
---
D
M
R
M
-----
A
L
W
FFEYALG
-
Q
AEDIA
I
R
MR
Q
Y
T
N
EY
LDN
I
T
PP
F
TKALF
T
YV
K
E
R
KYTFCTPGHMGGTA
Y
QKSPVG
C
LFYDFFG
G
NT
L
K
A
D
V
SISVTELGSLLDHTGPH
L
EAE
E
YIAR
T
FGA
EQ
SY
I
VTNGTSTSNKIVGMY
A
AP
S
GST
L
LIDRNCHKSL
A
HLLMM
N
DV
V
PV
W
LK
PTRNA
L
GILGGIP
RG
EF
T
RD
S
I
E
E
KV
A
A
T
T
-----
Q
AQWPVHAVITNSTYDGLLYNTD
W
IK
Q
TLDV
P
S
--
IHFDSAWVPYT
H
F
H
PIY
Q
GK
S
GMSGERV
----
A
GKVIFETQSTHK
M
LAALSQAS
L
IH
I
----
KG
EY
D
EE
A
FNEA
F
MMHTTTSP
S
Y
P
IVAS
V
ETAAAM
L
R
GN
P
GKRLIN
R
S
V
ERA
L
H
FRKE
V
Q
---
RLR
E
E
---
SDGWFFD
I
WQP
PQ
VD
E
--------------------
A
ECWP
V
A
PGE
Q
WHGF
--
S
D
A
D
A
N
HM
F
LDP
V
KVTILTPGM
D
E
Q
G
N
MSE
E
GIPAALVAK
F
LDE
R
GIVVEKTGPYNLLFLFSIGIDKTKA
MG
LLR
G
LT
E
FKR
S
YDLNLR
I
KNMLP
D
LY
A
EDPDFY
R
NMRIQDLAQ
G
IHKLI
RK
H
D
LP
G
LM
L
RAF
DT
LP
E
M
I
MTP
HQ
A
W
Q
RQ
I
K
G
E
VE
T
I
A
LE
Q
LVGR
V
S
ANMILPYPPGVPLLMPGEM
L
TEESR
T
VL
D
FL
L
MLCS
V
G
Q
HYPGFETDIHGA
KQDE
DG
V
Y
R
V
R
VLKMAG
fig|749528.3.peg.4626
Escherichia coli MS 45-1
MN
I
IAI
MGPH
GV
FY
K
D
EPI
K
EL
ES
AL
VA
Q
G
FQII
W
P
Q
N
S
V
DLLK
F
IE
H
N
P
RICGVIFDWD
E
Y
S
LDLC
S
D
I
N
QL
-------
NE
Y
LPLYAF
I
NT
H
ST
M
DVS
VQ
---
D
M
R
M
-----
A
L
W
FFEYALG
-
Q
AEDIA
I
R
MR
Q
Y
T
N
EY
LDN
I
T
PP
F
TKALF
T
YV
K
E
R
KYTFCTPGHMGGTA
Y
QKSPVG
C
LFYDFFG
G
NT
L
K
A
D
V
SISVTELGSLLDHTGPH
L
EAE
E
YIAR
T
FGA
EQ
SY
I
VTNGTSTSNKIVGMY
A
AP
S
GST
L
LIDRNCHKSL
A
HLLMM
N
DV
V
PV
W
LK
PTRNA
L
GILGGIP
RG
EF
T
RD
S
I
E
E
KV
A
A
T
T
-----
Q
AQWPVHAVITNSTYDGLLYNTD
W
IK
Q
TLDV
P
S
--
IHFDSAWVPYT
H
F
H
PIY
Q
GK
S
GMSGERV
----
A
GKVIFETQSTHK
M
LAALSQAS
L
IH
I
----
KG
EY
D
EE
A
FNEA
F
MMHTTTSP
S
Y
P
IVAS
V
ETAAAM
L
R
GN
P
GKRLIN
R
S
V
ERA
L
H
FRKE
V
Q
---
RLR
E
E
---
SDGWFFD
I
WQP
PQ
VD
E
--------------------
A
ECWP
V
A
PGE
Q
WHGF
--
S
D
A
D
A
N
HM
F
LDP
V
KVTILTPGM
D
E
Q
G
N
MSE
E
GIPAALVAK
F
LDE
R
GIVVEKTGPYNLLFLFSIGIDKTKA
MG
LLR
G
LT
E
FKR
S
YDLNLR
I
KNMLP
D
LY
A
EDPDFY
R
NMRIQDLAQ
G
IHKLI
RK
H
D
LP
G
LM
L
RAF
DT
LP
E
M
I
MTP
HQ
A
W
Q
RQ
I
K
G
E
VE
T
I
A
LE
Q
LVGR
V
S
ANMILPYPPGVPLLMPGEM
L
TEESR
T
VL
D
FL
L
MLCS
V
G
Q
HYPGFETDIHGA
KQDE
DG
V
Y
R
V
R
VLKMAG
fig|685038.3.peg.191
Escherichia coli O83:H1 str. NRG 857C
MN
I
IAI
MGPH
GV
FY
K
D
EPI
K
EL
ES
AL
VA
Q
G
FQII
W
P
Q
N
S
V
DLLK
F
IE
H
N
P
RICGVIFDWD
E
Y
S
LDLC
S
D
I
N
QL
-------
NE
Y
LPLYAF
I
NT
H
ST
M
DVS
VQ
---
D
M
R
M
-----
A
L
W
FFEYALG
-
Q
AEDIA
I
R
MR
Q
Y
T
N
EY
LDN
I
T
PP
F
TKALF
T
YV
K
E
R
KYTFCTPGHMGGTA
Y
QKSPVG
C
LFYDFFG
G
NT
L
K
A
D
V
SISVTELGSLLDHTGPH
L
EAE
E
YIAR
T
FGA
EQ
SY
I
VTNGTSTSNKIVGMY
A
AP
S
GST
L
LIDRNCHKSL
A
HLLMM
N
DV
V
PV
W
LK
PTRNA
L
GILGGIP
RG
EF
T
RD
S
I
E
E
KV
A
A
T
T
-----
Q
AQWPVHAVITNSTYDGLLYNTD
W
IK
Q
TLDV
P
S
--
IHFDSAWVPYT
H
F
H
PIY
Q
GK
S
GMSGERV
----
A
GKVIFETQSTHK
M
LAALSQAS
L
IH
I
----
KG
EY
D
EE
A
FNEA
F
MMHTTTSP
S
Y
P
IVAS
V
ETAAAM
L
R
GN
P
GKRLIN
R
S
V
ERA
L
H
FRKE
V
Q
---
RLR
E
E
---
SDGWFFD
I
WQP
PQ
VD
E
--------------------
A
ECWP
V
A
PGE
Q
WHGF
--
S
D
A
D
A
N
HM
F
LDP
V
KVTILTPGM
D
E
Q
G
N
MSE
E
GIPAALVAK
F
LDE
R
GIVVEKTGPYNLLFLFSIGIDKTKA
MG
LLR
G
LT
E
FKR
S
YDLNLR
I
KNMLP
D
LY
A
EDPDFY
R
NMRIQDLAQ
G
IHKLI
RK
H
D
LP
G
LM
L
RAF
DT
LP
E
M
I
MTP
HQ
A
W
Q
RQ
I
K
G
E
VE
T
I
A
LE
Q
LVGR
V
S
ANMILPYPPGVPLLMPGEM
L
TEESR
T
VL
D
FL
L
MLCS
V
G
Q
HYPGFETDIHGA
KQDE
DG
V
Y
R
V
R
VLKMAG
fig|585057.4.peg.203
Escherichia coli IAI39
MN
I
IAI
MGPH
GV
FY
K
D
EPI
K
EL
ES
AL
VA
Q
G
FQII
W
P
Q
N
S
V
DLLK
F
IE
H
N
P
RICGVIFDWD
V
Y
S
LDLC
S
D
I
N
QL
-------
NE
Y
LPLYAF
I
NT
H
ST
M
DVS
VQ
---
D
M
R
M
-----
A
L
W
FFEYALG
-
Q
AEDIA
I
R
MR
Q
Y
T
N
EY
LDN
I
T
PP
F
TKALF
T
YV
K
E
R
KYTFCTPGHMGGTA
Y
QKSPVG
C
LFYDFFG
G
NT
L
K
A
D
V
SISVTELGSLLDHTGPH
L
EAE
E
YIAR
T
FGA
EQ
SY
I
VTNGTSTSNKIVGMY
A
AP
S
GST
L
LIDRNCHKSL
A
HLLMM
N
DV
V
PV
W
LK
PTRNA
L
GILGGIP
RR
EF
T
RD
S
I
E
E
KV
A
A
T
T
-----
Q
AQWPVHAVITNSTYDGLLYNTD
W
IK
Q
TLDV
P
S
--
IHFDSAWVPYT
H
F
H
PIY
Q
GK
S
GMSGERV
----
A
GKVIFETQSTHK
M
LAALSQAS
L
IH
I
----
KG
EY
D
EE
A
FNEA
F
MMHTTTSP
S
Y
P
IVAS
V
ETAAAM
L
R
GN
P
GKRLIN
R
S
V
ERA
L
H
FRKE
V
Q
---
RLR
E
E
---
SDGWFFD
I
WQP
PQ
VD
E
--------------------
A
ECWP
V
A
PGE
Q
WHGF
--
S
D
A
D
A
N
HM
F
LDP
V
KVTILTPGM
D
E
Q
G
N
MSE
E
GIPAALVAK
F
LDE
R
GIVVEKTGPYNLLFLFSIGIDKTKA
MG
LLR
G
LT
E
FKR
S
YDLNLR
I
KNMLP
D
LY
A
EDPDFY
R
S
MRIQDLAQ
G
IHKLI
RK
H
D
LP
G
LM
L
RAF
DT
LP
E
M
I
MTP
HQ
A
W
Q
RQ
I
K
G
E
VE
T
I
A
LE
Q
LVGR
V
S
ANMILPYPPGVPLLMPGEM
L
T
K
ESR
T
VL
D
FL
L
MLCS
V
G
Q
HYPGFETDIHGA
KQDE
DG
V
Y
R
V
R
VLKMAG
fig|585057.6.peg.202
Escherichia coli IAI39
MN
I
IAI
MGPH
GV
FY
K
D
EPI
K
EL
ES
AL
VA
Q
G
FQII
W
P
Q
N
S
V
DLLK
F
IE
H
N
P
RICGVIFDWD
V
Y
S
LDLC
S
D
I
N
QL
-------
NE
Y
LPLYAF
I
NT
H
ST
M
DVS
VQ
---
D
M
R
M
-----
A
L
W
FFEYALG
-
Q
AEDIA
I
R
MR
Q
Y
T
N
EY
LDN
I
T
PP
F
TKALF
T
YV
K
E
R
KYTFCTPGHMGGTA
Y
QKSPVG
C
LFYDFFG
G
NT
L
K
A
D
V
SISVTELGSLLDHTGPH
L
EAE
E
YIAR
T
FGA
EQ
SY
I
VTNGTSTSNKIVGMY
A
AP
S
GST
L
LIDRNCHKSL
A
HLLMM
N
DV
V
PV
W
LK
PTRNA
L
GILGGIP
RR
EF
T
RD
S
I
E
E
KV
A
A
T
T
-----
Q
AQWPVHAVITNSTYDGLLYNTD
W
IK
Q
TLDV
P
S
--
IHFDSAWVPYT
H
F
H
PIY
Q
GK
S
GMSGERV
----
A
GKVIFETQSTHK
M
LAALSQAS
L
IH
I
----
KG
EY
D
EE
A
FNEA
F
MMHTTTSP
S
Y
P
IVAS
V
ETAAAM
L
R
GN
P
GKRLIN
R
S
V
ERA
L
H
FRKE
V
Q
---
RLR
E
E
---
SDGWFFD
I
WQP
PQ
VD
E
--------------------
A
ECWP
V
A
PGE
Q
WHGF
--
S
D
A
D
A
N
HM
F
LDP
V
KVTILTPGM
D
E
Q
G
N
MSE
E
GIPAALVAK
F
LDE
R
GIVVEKTGPYNLLFLFSIGIDKTKA
MG
LLR
G
LT
E
FKR
S
YDLNLR
I
KNMLP
D
LY
A
EDPDFY
R
S
MRIQDLAQ
G
IHKLI
RK
H
D
LP
G
LM
L
RAF
DT
LP
E
M
I
MTP
HQ
A
W
Q
RQ
I
K
G
E
VE
T
I
A
LE
Q
LVGR
V
S
ANMILPYPPGVPLLMPGEM
L
T
K
ESR
T
VL
D
FL
L
MLCS
V
G
Q
HYPGFETDIHGA
KQDE
DG
V
Y
R
V
R
VLKMAG
fig|670897.3.peg.2014
Escherichia coli 2362-75
MN
I
IAI
MGPH
GV
FY
K
D
EPI
K
EL
ES
AL
VA
Q
G
FQII
W
P
Q
N
S
V
DLLK
F
IE
H
N
P
RICGVIFDWD
E
Y
S
LDLC
S
D
I
N
QL
-------
NE
Y
LPLYAF
I
NT
H
ST
M
DVS
VQ
---
D
M
R
M
-----
A
L
W
FFEYALG
-
Q
AEDIA
I
R
MR
Q
Y
T
N
EY
LDN
I
T
PP
F
TKALF
T
YV
K
E
R
KYTFCTPGHMGGTA
Y
QKSPVG
C
LFYDFFG
G
NT
L
K
A
D
V
SISVTELGSLLDHTGPH
L
EAE
E
YIAR
T
FGA
EQ
SY
I
VTNGTSTSNKIVGMY
A
AP
S
GST
L
LIDRNCHKSL
A
HLLMM
N
DV
V
PV
W
LK
PTRNA
L
GILGGIP
RG
EF
T
RD
S
I
E
E
KV
A
A
T
T
-----
Q
AQWPVHAVITNSTYDGLLYNTD
W
IK
Q
TLDV
P
S
--
IHFDSAWVPYT
H
F
H
PIY
Q
GK
S
GMSGERV
----
A
GKVIFETQSTHK
M
LAALSQAS
L
IH
I
----
KG
EY
D
EE
A
FNEA
F
MMHTTTSP
S
Y
P
IVAS
V
ETAAAM
L
R
GN
P
GKRLIN
R
S
V
ERA
L
H
FRKE
V
Q
---
RLR
E
E
---
SDGWFFD
I
WQP
PQ
VD
E
--------------------
A
ECWP
V
A
PGE
Q
WHGF
--
S
D
A
D
A
N
HM
F
LDP
V
KVTILTPGM
D
E
Q
G
N
MSE
E
GIPAALVAK
F
LDE
R
GIVVEKTGPYNLLFLFSIGIDKTKA
MG
LLR
G
LT
E
FKR
S
YDLNLR
I
KNMLP
D
LY
A
EDPDFY
R
NMRIQDLAQ
G
IHKLI
RK
H
D
L
S
G
LM
L
RAF
DT
LP
E
M
I
MTP
HQ
A
W
Q
RQ
I
K
G
E
VE
T
I
A
LE
Q
LVGR
V
S
ANMILPYPPGVPLLMPGEM
L
T
K
ESR
T
VL
D
FL
L
MLCS
V
G
Q
HYPGFETDIHGA
KQDE
DG
V
Y
R
V
R
VLKMAG
fig|753642.3.peg.3434
Escherichia coli NC101
MN
I
IAI
MGPH
GV
FY
K
D
EPI
K
EL
ES
AL
VA
Q
G
FQII
W
P
Q
N
S
V
DLLK
F
IE
H
N
P
RICGVIFDWD
E
Y
S
LDLC
S
D
I
N
QL
-------
NE
Y
LPLYAF
I
NT
H
ST
M
DVS
VQ
---
D
M
R
M
-----
A
L
W
FFEYALG
-
Q
AEDIA
I
R
MR
Q
Y
T
N
EY
LDN
I
T
PP
F
TKALF
T
YV
K
E
R
KYTFCTPGHMGGTA
Y
QKSPVG
C
LFYDFFG
G
NT
L
K
A
D
V
SISVTELGSLLDHTGPH
L
EAE
E
YIAR
T
FGA
EQ
SY
I
VTNGTSTSNKIVGMY
A
AP
F
GST
L
LIDRNCHKSL
A
HLLMM
N
DV
V
PV
W
LK
PTRNA
L
GILGGIP
RR
EF
T
RD
S
I
E
E
KV
A
A
T
T
-----
Q
AQWPVHAVITNSTYDGLLYNTD
W
IK
Q
TLDV
P
S
--
IHFDSAWVPYT
H
F
H
PIY
Q
GK
S
GMSGERV
----
A
GKVIFETQSTHK
M
LAALSQAS
L
IH
I
----
KG
EY
D
EE
A
FNEA
F
MMHTTTSP
S
Y
P
IVAS
V
ETAAAM
L
R
GN
P
GKRLIN
R
S
V
ERA
L
H
FRKE
V
Q
---
RLR
E
E
---
SDGWFFD
I
WQP
PQ
VD
E
--------------------
A
ECWP
V
A
PGE
Q
WHGF
--
S
D
A
D
A
N
HM
F
LDP
V
KVTILTPGM
D
E
Q
G
N
MSE
E
G
S
PAALVAK
F
LDE
R
GIVVEKTGPYNLLFLFSIGIDKTKA
MG
LLR
G
LT
E
FKR
S
YDLNLR
I
KNMLP
D
LY
A
EDPDFY
R
NMRIQDLAQ
G
IHKLI
RK
H
D
LP
G
LM
L
RAF
DT
LP
E
M
I
MTP
HQ
A
W
Q
RQ
I
K
G
E
VE
T
I
A
LE
Q
LVGR
V
S
ANMILPYPPGVPLLMPGEM
L
TEESR
T
VL
D
FL
L
MLCS
V
G
Q
HYPGFETDIHGA
KQDE
DG
V
Y
R
V
R
VLKMAG
fig|405955.13.peg.198
Escherichia coli APEC O1
MN
I
IAI
MGPH
GV
FY
K
D
EPI
K
EL
ES
AL
VA
Q
G
FQII
W
P
Q
N
S
V
DLLK
F
IE
H
N
P
RICGVIFDWD
E
Y
S
LDLC
S
D
I
N
QL
-------
NE
Y
LPLYAF
I
NT
H
ST
M
DVS
VQ
---
D
M
R
M
-----
A
L
W
FFEYALG
-
Q
AEDIA
I
R
MR
Q
Y
T
N
EY
LDN
I
T
PP
F
TKALF
T
YV
K
E
R
KYTFCTPGHMGGTA
Y
QKSPVG
C
LFYDFFG
G
NT
L
K
A
D
V
SISVTELGSLLDHTGPH
L
EAE
E
YIAR
T
FGA
EQ
SY
I
VTNGTSTSNKIVGMY
A
AP
S
GST
L
LIDRNCHKSL
A
HLLMM
N
DV
V
PV
W
LK
PTRNA
L
GILGGIP
RG
EF
T
RD
S
I
E
E
KV
A
A
T
T
-----
Q
AQWPVHAVITNSTYDGLLYNTD
W
IK
Q
TLDV
P
S
--
IHFDSAWVPYT
H
F
H
PIY
Q
GK
S
GMSGERV
----
A
GKVIFETQSTHK
M
LAALSQAS
L
IH
I
----
KG
EY
D
EE
A
FNEA
F
MMHTTTSP
S
Y
P
IVAS
V
ETAAAM
L
R
GN
P
GKRLIN
R
S
V
ERA
L
H
FRKE
V
Q
---
RLR
E
E
---
SDGWFFD
I
WQP
PQ
VD
E
--------------------
A
ECWP
V
A
PGE
Q
WHGF
--
S
D
A
D
A
N
HM
F
LDP
V
KVTILTPGM
D
E
H
G
N
MSE
E
GIPAALVAK
F
LDE
R
GIVVEKTGPYNLLFLFSIGIDKTKA
MG
LLR
G
LT
E
FKR
S
YDLNLR
I
KNMLP
D
LY
A
EDPDFY
R
NMRIQDLAQ
G
IHKLI
RK
H
D
LP
G
LM
L
RAF
DT
LP
E
M
I
MTP
HQ
A
W
Q
RQ
I
K
G
E
VE
T
I
A
LE
Q
LVGR
V
S
ANMILPYPPGVPLLMPGEM
L
TEESR
T
VL
D
FL
L
MLCS
V
G
Q
HYPGFETDIHGA
KQDE
DG
V
Y
R
V
R
VLKMAG
fig|405955.9.peg.168
Escherichia coli APEC O1
MN
I
IAI
MGPH
GV
FY
K
D
EPI
K
EL
ES
AL
VA
Q
G
FQII
W
P
Q
N
S
V
DLLK
F
IE
H
N
P
RICGVIFDWD
E
Y
S
LDLC
S
D
I
N
QL
-------
NE
Y
LPLYAF
I
NT
H
ST
M
DVS
VQ
---
D
M
R
M
-----
A
L
W
FFEYALG
-
Q
AEDIA
I
R
MR
Q
Y
T
N
EY
LDN
I
T
PP
F
TKALF
T
YV
K
E
R
KYTFCTPGHMGGTA
Y
QKSPVG
C
LFYDFFG
G
NT
L
K
A
D
V
SISVTELGSLLDHTGPH
L
EAE
E
YIAR
T
FGA
EQ
SY
I
VTNGTSTSNKIVGMY
A
AP
S
GST
L
LIDRNCHKSL
A
HLLMM
N
DV
V
PV
W
LK
PTRNA
L
GILGGIP
RG
EF
T
RD
S
I
E
E
KV
A
A
T
T
-----
Q
AQWPVHAVITNSTYDGLLYNTD
W
IK
Q
TLDV
P
S
--
IHFDSAWVPYT
H
F
H
PIY
Q
GK
S
GMSGERV
----
A
GKVIFETQSTHK
M
LAALSQAS
L
IH
I
----
KG
EY
D
EE
A
FNEA
F
MMHTTTSP
S
Y
P
IVAS
V
ETAAAM
L
R
GN
P
GKRLIN
R
S
V
ERA
L
H
FRKE
V
Q
---
RLR
E
E
---
SDGWFFD
I
WQP
PQ
VD
E
--------------------
A
ECWP
V
A
PGE
Q
WHGF
--
S
D
A
D
A
N
HM
F
LDP
V
KVTILTPGM
D
E
H
G
N
MSE
E
GIPAALVAK
F
LDE
R
GIVVEKTGPYNLLFLFSIGIDKTKA
MG
LLR
G
LT
E
FKR
S
YDLNLR
I
KNMLP
D
LY
A
EDPDFY
R
NMRIQDLAQ
G
IHKLI
RK
H
D
LP
G
LM
L
RAF
DT
LP
E
M
I
MTP
HQ
A
W
Q
RQ
I
K
G
E
VE
T
I
A
LE
Q
LVGR
V
S
ANMILPYPPGVPLLMPGEM
L
TEESR
T
VL
D
FL
L
MLCS
V
G
Q
HYPGFETDIHGA
KQDE
DG
V
Y
R
V
R
VLKMAG
fig|869729.3.peg.5103
Escherichia coli UM146
MN
I
IAI
MGPH
GV
FY
K
D
EPI
K
EL
ES
AL
VA
Q
G
FQII
W
P
Q
N
S
V
DLLK
F
IE
H
N
P
RICGVIFDWD
E
Y
S
LDLC
S
D
I
N
QL
-------
NE
Y
LPLYAF
I
NT
H
ST
M
DVS
VQ
---
D
M
R
M
-----
A
L
W
FFEYALG
-
Q
AEDIA
I
R
MR
Q
Y
T
N
EY
LDN
I
T
PP
F
TKALF
T
YV
K
E
R
KYTFCTPGHMGGTA
Y
QKSPVG
C
LFYDFFG
G
NT
L
K
A
D
V
SISVTELGSLLDHTGPH
L
EAE
E
YIAR
T
FGA
EQ
SY
I
VTNGTSTSNKIVGMY
A
AP
S
GST
L
LIDRNCHKSL
A
HLLMM
N
DV
V
PV
W
LK
PTRNA
L
GILGGIP
RG
EF
T
RD
S
I
E
E
KV
A
A
T
T
-----
Q
AQWPVHAVITNSTYDGLLYNTD
W
IK
Q
TLDV
P
S
--
IHFDSAWVPYT
H
F
H
PIY
Q
GK
S
GMSGERV
----
A
GKVIFETQSTHK
M
LAALSQAS
L
IH
I
----
KG
EY
D
EE
A
FNEA
F
MMHTTTSP
S
Y
P
IVAS
V
ETAAAM
L
R
GN
P
GKRLIN
R
S
V
ERA
L
H
FRKE
V
Q
---
RLR
E
E
---
SDGWFFD
I
WQP
PQ
VD
E
--------------------
A
ECWP
V
A
PGE
Q
WHGF
--
S
D
A
D
A
N
HM
F
LDP
V
KVTILTPGM
D
E
H
G
N
MSE
E
GIPAALVAK
F
LDE
R
GIVVEKTGPYNLLFLFSIGIDKTKA
MG
LLR
G
LT
E
FKR
S
YDLNLR
I
KNMLP
D
LY
A
EDPDFY
R
NMRIQDLAQ
G
IHKLI
RK
H
D
LP
G
LM
L
RAF
DT
LP
E
M
I
MTP
HQ
A
W
Q
RQ
I
K
G
E
VE
T
I
A
LE
Q
LVGR
V
S
ANMILPYPPGVPLLMPGEM
L
TEESR
T
VL
D
FL
L
MLCS
V
G
Q
HYPGFETDIHGA
KQDE
DG
V
Y
R
V
R
VLKMAG
fig|364106.7.peg.330
Escherichia coli UTI89
MN
I
IAI
MGPH
GV
FY
K
D
EPI
K
EL
ES
AL
VA
Q
G
FQII
W
P
Q
N
S
V
DLLK
F
IE
H
N
P
RICGVIFDWD
E
Y
S
LDLC
S
D
I
N
QL
-------
NE
Y
LPLYAF
I
NT
H
ST
M
DVS
VQ
---
D
M
R
M
-----
A
L
W
FFEYALG
-
Q
AEDIA
I
R
MR
Q
Y
T
N
EY
LDN
I
T
PP
F
TKALF
T
YV
K
E
R
KYTFCTPGHMGGTA
Y
QKSPVG
C
LFYDFFG
G
NT
L
K
A
D
V
SISVTELGSLLDHTGPH
L
EAE
E
YIAR
T
FGA
EQ
SY
I
VTNGTSTSNKIVGMY
A
AP
S
GST
L
LIDRNCHKSL
A
HLLMM
N
DV
V
PV
W
LK
PTRNA
L
GILGGIP
RG
EF
T
RD
S
I
E
E
KV
A
A
T
T
-----
Q
AQWPVHAVITNSTYDGLLYNTD
W
IK
Q
TLDV
P
S
--
IHFDSAWVPYT
H
F
H
PIY
Q
GK
S
GMSGERV
----
A
GKVIFETQSTHK
M
LAALSQAS
L
IH
I
----
KG
EY
D
EE
A
FNEA
F
MMHTTTSP
S
Y
P
IVAS
V
ETAAAM
L
R
GN
P
GKRLIN
R
S
V
ERA
L
H
FRKE
V
Q
---
RLR
E
E
---
SDGWFFD
I
WQP
PQ
VD
E
--------------------
A
ECWP
V
A
PGE
Q
WHGF
--
S
D
A
D
A
N
HM
F
LDP
V
KVTILTPGM
D
E
H
G
N
MSE
E
GIPAALVAK
F
LDE
R
GIVVEKTGPYNLLFLFSIGIDKTKA
MG
LLR
G
LT
E
FKR
S
YDLNLR
I
KNMLP
D
LY
A
EDPDFY
R
NMRIQDLAQ
G
IHKLI
RK
H
D
LP
G
LM
L
RAF
DT
LP
E
M
I
MTP
HQ
A
W
Q
RQ
I
K
G
E
VE
T
I
A
LE
Q
LVGR
V
S
ANMILPYPPGVPLLMPGEM
L
TEESR
T
VL
D
FL
L
MLCS
V
G
Q
HYPGFETDIHGA
KQDE
DG
V
Y
R
V
R
VLKMAG
fig|364106.8.peg.328
Escherichia coli UTI89
MN
I
IAI
MGPH
GV
FY
K
D
EPI
K
EL
ES
AL
VA
Q
G
FQII
W
P
Q
N
S
V
DLLK
F
IE
H
N
P
RICGVIFDWD
E
Y
S
LDLC
S
D
I
N
QL
-------
NE
Y
LPLYAF
I
NT
H
ST
M
DVS
VQ
---
D
M
R
M
-----
A
L
W
FFEYALG
-
Q
AEDIA
I
R
MR
Q
Y
T
N
EY
LDN
I
T
PP
F
TKALF
T
YV
K
E
R
KYTFCTPGHMGGTA
Y
QKSPVG
C
LFYDFFG
G
NT
L
K
A
D
V
SISVTELGSLLDHTGPH
L
EAE
E
YIAR
T
FGA
EQ
SY
I
VTNGTSTSNKIVGMY
A
AP
S
GST
L
LIDRNCHKSL
A
HLLMM
N
DV
V
PV
W
LK
PTRNA
L
GILGGIP
RG
EF
T
RD
S
I
E
E
KV
A
A
T
T
-----
Q
AQWPVHAVITNSTYDGLLYNTD
W
IK
Q
TLDV
P
S
--
IHFDSAWVPYT
H
F
H
PIY
Q
GK
S
GMSGERV
----
A
GKVIFETQSTHK
M
LAALSQAS
L
IH
I
----
KG
EY
D
EE
A
FNEA
F
MMHTTTSP
S
Y
P
IVAS
V
ETAAAM
L
R
GN
P
GKRLIN
R
S
V
ERA
L
H
FRKE
V
Q
---
RLR
E
E
---
SDGWFFD
I
WQP
PQ
VD
E
--------------------
A
ECWP
V
A
PGE
Q
WHGF
--
S
D
A
D
A
N
HM
F
LDP
V
KVTILTPGM
D
E
H
G
N
MSE
E
GIPAALVAK
F
LDE
R
GIVVEKTGPYNLLFLFSIGIDKTKA
MG
LLR
G
LT
E
FKR
S
YDLNLR
I
KNMLP
D
LY
A
EDPDFY
R
NMRIQDLAQ
G
IHKLI
RK
H
D
LP
G
LM
L
RAF
DT
LP
E
M
I
MTP
HQ
A
W
Q
RQ
I
K
G
E
VE
T
I
A
LE
Q
LVGR
V
S
ANMILPYPPGVPLLMPGEM
L
TEESR
T
VL
D
FL
L
MLCS
V
G
Q
HYPGFETDIHGA
KQDE
DG
V
Y
R
V
R
VLKMAG
fig|562.376.peg.169
Escherichia coli WV_060327
MN
I
IAI
MGPH
GV
FY
K
D
EPI
K
EL
ES
AL
VA
Q
G
FQII
W
P
Q
N
S
V
DLLK
F
IE
H
N
P
RICGVIFDWD
E
Y
S
LDLC
S
D
I
N
QL
-------
NE
Y
LPLYAF
I
NT
H
ST
M
DVS
VQ
---
D
M
R
M
-----
A
L
W
FFEYALG
-
Q
AEDIA
I
R
MR
Q
Y
T
N
EY
LDN
I
T
PP
F
TKALF
T
YV
K
E
R
KYTFCTPGHMGGTA
Y
QKSPVG
C
LFYDFFG
G
NT
L
K
A
D
V
SISVTELGSLLDHTGPH
L
EAE
E
YIAR
T
FGA
EQ
SY
I
VTNGTSTSNKIVGMY
A
AP
S
GST
L
LIDRNCHKSL
A
HLLMM
N
DV
V
PV
W
LK
PTRNA
L
GILGGIP
RG
EF
T
RD
S
I
E
E
KV
A
A
T
T
-----
Q
AQWPVHAVITNSTYDGLLYNTD
W
IK
Q
TLDV
P
S
--
IHFDSAWVPYT
H
F
H
PIY
Q
GK
S
GMSGERV
----
A
GKVIFETQSTHK
M
LAALSQAS
L
IH
I
----
KG
EY
D
EE
A
FNEA
F
MMHTTTSP
S
Y
P
IVAS
V
ETAAAM
L
R
GN
P
GKRLIN
R
S
V
ERA
L
H
FRKE
V
Q
---
RLR
E
E
---
SDGWFFD
I
WQP
PQ
VD
E
--------------------
A
ECWP
V
A
PGE
Q
WHGF
--
S
D
A
D
A
N
HM
F
LDP
V
KVTILTPGM
D
E
Q
G
N
MSE
E
GIPAALVAK
F
LDE
R
GIVVEKTGPYNLLFLFSIGIDKTKA
MG
LLR
G
LT
E
FKR
S
YDLNLR
I
KNMLP
D
LY
A
EDPDFY
R
S
MRIQDLAQ
G
IHKLI
RK
H
D
LP
G
LM
L
RAF
DT
LP
E
M
I
MTP
HQ
A
W
Q
RQ
I
K
G
E
VE
T
I
A
LE
Q
LVGR
V
S
ANMILPYPPGVPLLMPGEM
L
TEESR
T
VL
D
FL
L
MLCS
V
G
Q
HYPGFETDIHGA
KQDE
DG
V
Y
R
V
R
VLKMAG
fig|656440.3.peg.5278
Escherichia coli TA206
MN
I
IAI
MGPH
GV
FY
K
D
EPI
K
EL
ES
AL
VA
Q
G
FQII
W
P
Q
N
S
V
DLLK
F
IE
H
N
P
RICGVIFDWD
E
Y
S
LDLC
S
D
I
N
QL
-------
NE
Y
LPLYAF
I
NT
H
ST
M
DVS
VQ
---
D
M
R
M
-----
A
L
W
FFEYALG
-
Q
AEDIA
I
R
MR
Q
Y
T
N
EY
LDN
I
T
PP
F
TKALF
T
YV
K
E
R
KYTFCTPGHMGGTA
Y
QKSPVG
C
LFYDFFG
G
NT
L
K
A
D
V
SISVTELGSLLDHTGPH
L
EAE
E
YIAR
T
FGA
EQ
SY
I
VTNGTSTSNKIVGMY
A
AP
S
GST
L
LIDRNCHKSL
A
HLLMM
N
DV
V
PV
W
LK
PTRNA
L
GILGGIP
RG
EF
T
RD
S
I
E
E
KV
A
A
T
T
-----
Q
AQWPVHAVITNSTYDGLLYNTD
W
IK
Q
TLDV
P
S
--
IHFDSAWVPYT
H
F
H
PIY
Q
GK
S
GMSGERV
----
A
GKVIFETQSTHK
M
LAALSQAS
L
IH
I
----
KG
EY
D
EE
A
FNEA
F
MMHTTTSP
S
Y
P
IVAS
V
ETAAAM
L
R
GN
P
GKRLIN
R
S
V
ERA
L
H
FRKE
V
Q
---
RLR
E
E
---
SDGWFFD
I
WQP
PQ
VD
E
--------------------
A
ECWP
V
A
PGE
Q
WHGF
--
S
D
A
D
A
N
HM
F
LDP
V
KVTILTPGM
D
E
Q
G
N
MSE
E
GIPAALVAK
F
LDE
R
GIVVEKTGPYNLLFLFSIGIDKTKA
MG
LLR
G
L
M
E
FKR
S
YDLNLR
I
KNMLP
D
LY
A
EDPDFY
R
NMRIQDLAQ
G
IHKLI
RK
H
D
LP
G
LM
L
RAF
DT
LP
E
M
I
MTP
HQ
A
W
Q
RQ
I
K
G
E
VE
T
I
A
LE
Q
LVGR
V
S
ANMILPYPPGVPLLMPGEM
L
TEESR
T
VL
D
FL
L
MLCS
V
G
Q
HYPGFETDIHGA
KQDE
DG
V
Y
R
V
R
VLKMAG
fig|585035.6.peg.199
Escherichia coli S88
MN
I
IAI
MGPH
GV
FY
K
D
EPI
K
EL
ES
AL
VA
Q
G
FQII
W
P
Q
N
S
V
DLLK
F
IE
H
N
P
RICGVIFDWD
E
Y
S
LDLC
S
D
I
N
QL
-------
NE
Y
LPLYAF
I
NT
H
ST
M
DVS
VQ
---
D
M
R
M
-----
A
L
W
FFEYALG
-
Q
AEDIA
I
R
MR
Q
Y
T
N
EY
LDN
I
T
PP
F
TKALF
T
YV
K
E
R
KYTFCTPGHMGGTA
Y
QKSPVG
C
LFYDFFG
G
NT
L
K
A
D
V
SISVTELGSLLDHTGPH
L
EAE
E
YIAR
T
FGA
EQ
SY
I
VTNGTSTSNKIVGMY
A
AP
S
GST
L
LIDRNCHKSL
A
HLLMM
N
DV
V
PV
W
LK
PTRNA
L
GILGGIP
RG
EF
T
RD
S
I
E
E
KV
A
A
T
T
-----
Q
AQWPVHAVITNSTYDGLLYNTD
W
IK
Q
TLDV
P
S
--
IHFDSAWVPYT
H
F
H
PIY
Q
GK
S
GMSGERV
----
A
GKVIFETQSTHK
M
LAALSQAS
L
IH
I
----
KG
EY
D
EE
A
FNEA
F
MMHTTTSP
S
Y
P
IVAS
V
ETAAAM
L
R
GN
P
GKRLIN
R
S
V
ERA
L
H
FRKE
V
Q
---
RLR
E
E
---
SDGWFFD
I
WQP
PQ
VD
E
--------------------
A
ECWP
V
A
PGE
Q
WHGF
--
S
D
A
D
A
N
HM
F
LDP
V
KVTILTPGM
D
E
H
G
N
MSE
E
GIPAALVAK
F
LDE
R
GIVVEKTGPYNLLFLFSIGIDKTKA
MG
LLR
G
LT
E
FKR
S
YDLNLR
I
KNMLP
D
LY
A
K
DPDFY
R
NMRIQDLAQ
G
IHKLI
RK
H
D
LP
G
LM
L
RAF
DT
LP
E
M
I
MTP
HQ
A
W
Q
RQ
I
K
G
E
VE
T
I
A
LE
Q
LVGR
V
S
ANMILPYPPGVPLLMPGEM
L
TEESR
T
VL
D
FL
L
MLCS
V
G
Q
HYPGFETDIHGA
KQDE
DG
V
Y
R
V
R
VLKMAG
fig|585397.7.peg.196
Escherichia coli ED1a
MN
I
IAI
MGPH
GV
FY
K
D
EPI
K
EL
ES
AL
VA
Q
G
FQII
W
P
Q
N
S
V
DLLK
F
IE
H
N
P
RICGVIFDWD
E
Y
S
LDLC
S
D
I
N
QL
-------
NE
Y
LPLYAF
I
NT
H
ST
M
DVS
VQ
---
D
M
R
M
-----
A
L
W
FFEYALG
-
Q
AEDIA
I
R
MR
Q
C
T
N
EY
LDN
I
T
PP
F
TKALF
T
YV
K
E
R
KYTFCTPGHMGGTA
Y
QKSPVG
C
LFYDFFG
G
NT
L
K
A
D
V
SISVTELGSLLDHTGPH
L
EAE
E
YIAR
T
FGA
EQ
SY
I
VTNGTSTSNKIVGMY
A
AP
S
GST
L
LIDRNCHKSL
A
HLLMM
N
DV
V
PV
W
LK
PTRNA
L
GILGGIP
RG
EF
T
RD
S
I
E
E
KV
A
A
T
T
-----
Q
AQWPVHAVITNSTYDGLLYNTD
W
IK
Q
TLDV
P
S
--
IHFDSAWVPYT
H
F
H
PIY
Q
GK
S
GMSGERV
----
A
GKVIFETQSTHK
M
LAALSQAS
L
IH
I
----
KG
EY
D
EE
A
FNEA
F
MMHTTTSP
S
Y
P
IVAS
V
ETAAAM
L
R
GN
P
GKRLIN
R
S
V
ERA
L
H
FRKE
V
Q
---
RLR
E
E
---
SDGWFFD
I
WQP
PQ
VD
E
--------------------
A
ECWP
V
A
PGE
Q
WHGF
--
S
D
A
D
A
N
HM
F
LDP
V
KVTILTPGM
D
E
Q
G
N
MSE
E
GIPAALVAK
F
LDE
R
GIVVEKTGPYNLLFLFSIGIDKTKA
MG
LLR
G
LT
E
FKR
S
YDLNLR
I
KNMLP
D
LY
A
EDPDFY
R
NMRIQDLAQ
G
IHKLI
RK
H
D
LP
G
LM
L
RAF
DT
LP
E
M
I
MTP
HQ
A
W
Q
RQ
I
K
G
E
VE
T
I
A
LE
Q
LVGR
V
S
ANMILPYPPGVPLLMPGEM
L
TEESR
T
VL
D
FL
L
MLCS
V
G
Q
HYPGFETDIHGA
KQDE
DG
V
Y
R
V
R
VLKMAG
fig|585397.9.peg.196
Escherichia coli ED1a
MN
I
IAI
MGPH
GV
FY
K
D
EPI
K
EL
ES
AL
VA
Q
G
FQII
W
P
Q
N
S
V
DLLK
F
IE
H
N
P
RICGVIFDWD
E
Y
S
LDLC
S
D
I
N
QL
-------
NE
Y
LPLYAF
I
NT
H
ST
M
DVS
VQ
---
D
M
R
M
-----
A
L
W
FFEYALG
-
Q
AEDIA
I
R
MR
Q
C
T
N
EY
LDN
I
T
PP
F
TKALF
T
YV
K
E
R
KYTFCTPGHMGGTA
Y
QKSPVG
C
LFYDFFG
G
NT
L
K
A
D
V
SISVTELGSLLDHTGPH
L
EAE
E
YIAR
T
FGA
EQ
SY
I
VTNGTSTSNKIVGMY
A
AP
S
GST
L
LIDRNCHKSL
A
HLLMM
N
DV
V
PV
W
LK
PTRNA
L
GILGGIP
RG
EF
T
RD
S
I
E
E
KV
A
A
T
T
-----
Q
AQWPVHAVITNSTYDGLLYNTD
W
IK
Q
TLDV
P
S
--
IHFDSAWVPYT
H
F
H
PIY
Q
GK
S
GMSGERV
----
A
GKVIFETQSTHK
M
LAALSQAS
L
IH
I
----
KG
EY
D
EE
A
FNEA
F
MMHTTTSP
S
Y
P
IVAS
V
ETAAAM
L
R
GN
P
GKRLIN
R
S
V
ERA
L
H
FRKE
V
Q
---
RLR
E
E
---
SDGWFFD
I
WQP
PQ
VD
E
--------------------
A
ECWP
V
A
PGE
Q
WHGF
--
S
D
A
D
A
N
HM
F
LDP
V
KVTILTPGM
D
E
Q
G
N
MSE
E
GIPAALVAK
F
LDE
R
GIVVEKTGPYNLLFLFSIGIDKTKA
MG
LLR
G
LT
E
FKR
S
YDLNLR
I
KNMLP
D
LY
A
EDPDFY
R
NMRIQDLAQ
G
IHKLI
RK
H
D
LP
G
LM
L
RAF
DT
LP
E
M
I
MTP
HQ
A
W
Q
RQ
I
K
G
E
VE
T
I
A
LE
Q
LVGR
V
S
ANMILPYPPGVPLLMPGEM
L
TEESR
T
VL
D
FL
L
MLCS
V
G
Q
HYPGFETDIHGA
KQDE
DG
V
Y
R
V
R
VLKMAG
fig|656417.3.peg.290
Escherichia coli M605
MN
I
IAI
MGPH
GV
FY
K
D
EPI
K
EL
ES
AL
VA
Q
G
FQII
W
P
Q
N
S
V
DLLK
F
IE
H
N
P
RICGVIFDWD
E
Y
S
LDLC
S
D
I
N
QL
-------
NE
Y
LPLYAF
I
NT
H
ST
M
DVS
VQ
---
D
M
R
M
-----
A
L
W
FFEYALG
-
Q
AEDIA
I
R
MR
Q
Y
T
N
EY
LDN
I
T
PP
F
TKALF
T
YV
K
E
R
KYTFCTPGHMGGTA
Y
QKSPVG
C
LFYDFFG
G
NT
L
K
A
D
V
SISVTELGSLLDHTGPH
L
EAE
E
YIAR
T
FGA
EQ
SY
I
VTNGTSTSNKIVGMY
A
AP
S
GST
L
LIDRNCHKSL
A
HLLMM
N
DV
V
PV
W
LK
PTRNA
L
GILGGIP
RG
EF
T
RD
S
I
E
E
KV
A
A
T
T
-----
Q
AQWPVHAVITNSTYDGLLYNTD
W
IK
Q
TLDV
P
S
--
IHFDSAWVPYT
H
F
H
PIY
Q
GK
S
GMSGERV
----
A
GKVIFETQSTHK
M
LAALSQAS
L
IH
I
----
KG
EY
D
EE
A
FNEA
F
MMHTTTSP
S
Y
P
IVAS
V
ETAAAM
L
R
GN
P
GKRLIN
R
S
V
ERA
L
H
FRKE
V
Q
---
RLR
E
E
---
SDGWFFD
I
WQP
PQ
VD
E
--------------------
A
ECW
H
V
A
PGE
Q
WHGF
--
S
D
A
D
A
N
HM
F
LDP
V
KVTILTPGM
D
E
Q
G
N
MSE
E
GIPAALVAK
F
LDE
R
GIVVEKTGPYNLLFLFSIGIDKTKA
MG
LLR
G
LT
E
FKR
S
YDLNLR
I
KNMLP
D
LY
A
EDPDFY
R
NMRIQDLAQ
G
IHKLI
RK
H
D
LP
G
LM
L
RAF
DT
LP
E
M
I
MTP
HQ
A
W
Q
RQ
I
K
G
E
VE
T
I
A
LE
Q
LVGR
V
S
ANMILPYPPGVPLLMPGEM
L
TEESR
T
VL
D
FL
L
MLCS
V
G
Q
HYPGFETDIHGA
KQDE
DG
V
Y
R
V
R
VLKMAG
fig|216593.1.peg.3375
Escherichia coli E2348/69
MN
I
IAI
MGPH
GV
FY
K
D
EPI
K
EL
ES
AL
VA
Q
G
FQII
W
P
Q
N
S
V
DLLK
F
IE
H
N
P
RICGVIFDWD
E
Y
S
LDLC
S
D
I
N
QL
-------
NE
Y
LPLYAF
I
NT
H
ST
M
DVS
VQ
---
D
M
R
M
-----
A
L
W
FFEYALG
-
L
AEDIA
I
R
MR
Q
Y
T
N
EY
LDN
I
T
PP
F
TKALF
T
YV
K
E
R
KYTFCTPGHMGGTA
Y
QKSPVG
C
LFYDFFG
G
NT
L
K
A
D
V
SISVTELGSLLDHTGPH
L
EAE
E
YIAR
T
FGA
EQ
SY
I
VTNGTSTSNKIVGMY
A
AP
S
GST
L
LIDRNCHKSL
A
HLLMM
N
DV
V
PV
W
LK
PTRNA
L
GILGGIP
RG
EF
T
RD
S
I
E
E
KV
A
A
T
T
-----
Q
AQWPVHAVITNSTYDGLLYNTD
W
IK
Q
TLDV
P
S
--
IHFDSAWVPYT
H
F
H
PIY
Q
GK
S
GMSGERV
----
A
GKVIFETQSTHK
M
LAALSQAS
L
IH
I
----
KG
EY
D
EE
A
FNEA
F
MMHTTTSP
S
Y
P
IVAS
V
ETAAAM
L
R
GN
P
GKRLIN
R
S
V
ERA
L
H
FRKE
V
Q
---
RLR
E
E
---
SDGWFFD
I
WQP
PQ
VD
E
--------------------
A
ECWP
V
A
PGE
Q
WHGF
--
S
D
A
D
A
N
HM
F
LDP
V
KVTILTPGM
D
E
Q
G
N
MSE
E
GIPAALVAK
F
LDE
R
GIVVEKTGPYNLLFLFSIGIDKTKA
MG
LLR
G
LT
E
FKR
S
YDLNLR
I
KNMLP
D
LY
A
EDPDFY
R
NMRIQDLAQ
G
IHKLI
RK
H
D
L
S
G
LM
L
RAF
DT
LP
E
M
I
MTP
HQ
A
W
Q
RQ
I
K
G
E
VE
T
I
A
LE
Q
LVGR
V
S
ANMILPYPPGVPLLMPGEM
L
T
K
ESR
T
VL
D
FL
L
MLCS
V
G
Q
HYPGFETDIHGA
KQDE
DG
V
Y
R
V
R
VLKMAG
fig|574521.7.peg.202
Escherichia coli O127:H6 str. E2348/69
MN
I
IAI
MGPH
GV
FY
K
D
EPI
K
EL
ES
AL
VA
Q
G
FQII
W
P
Q
N
S
V
DLLK
F
IE
H
N
P
RICGVIFDWD
E
Y
S
LDLC
S
D
I
N
QL
-------
NE
Y
LPLYAF
I
NT
H
ST
M
DVS
VQ
---
D
M
R
M
-----
A
L
W
FFEYALG
-
L
AEDIA
I
R
MR
Q
Y
T
N
EY
LDN
I
T
PP
F
TKALF
T
YV
K
E
R
KYTFCTPGHMGGTA
Y
QKSPVG
C
LFYDFFG
G
NT
L
K
A
D
V
SISVTELGSLLDHTGPH
L
EAE
E
YIAR
T
FGA
EQ
SY
I
VTNGTSTSNKIVGMY
A
AP
S
GST
L
LIDRNCHKSL
A
HLLMM
N
DV
V
PV
W
LK
PTRNA
L
GILGGIP
RG
EF
T
RD
S
I
E
E
KV
A
A
T
T
-----
Q
AQWPVHAVITNSTYDGLLYNTD
W
IK
Q
TLDV
P
S
--
IHFDSAWVPYT
H
F
H
PIY
Q
GK
S
GMSGERV
----
A
GKVIFETQSTHK
M
LAALSQAS
L
IH
I
----
KG
EY
D
EE
A
FNEA
F
MMHTTTSP
S
Y
P
IVAS
V
ETAAAM
L
R
GN
P
GKRLIN
R
S
V
ERA
L
H
FRKE
V
Q
---
RLR
E
E
---
SDGWFFD
I
WQP
PQ
VD
E
--------------------
A
ECWP
V
A
PGE
Q
WHGF
--
S
D
A
D
A
N
HM
F
LDP
V
KVTILTPGM
D
E
Q
G
N
MSE
E
GIPAALVAK
F
LDE
R
GIVVEKTGPYNLLFLFSIGIDKTKA
MG
LLR
G
LT
E
FKR
S
YDLNLR
I
KNMLP
D
LY
A
EDPDFY
R
NMRIQDLAQ
G
IHKLI
RK
H
D
L
S
G
LM
L
RAF
DT
LP
E
M
I
MTP
HQ
A
W
Q
RQ
I
K
G
E
VE
T
I
A
LE
Q
LVGR
V
S
ANMILPYPPGVPLLMPGEM
L
T
K
ESR
T
VL
D
FL
L
MLCS
V
G
Q
HYPGFETDIHGA
KQDE
DG
V
Y
R
V
R
VLKMAG
fig|431946.3.peg.206
Escherichia coli SE15
MN
I
IAI
MGPH
GV
FY
K
D
EPI
K
EL
ES
AL
VA
Q
G
FQII
W
P
Q
N
S
V
DLLK
F
IE
H
N
P
RICGVIFDWD
E
Y
S
LDLC
S
D
I
N
QL
-------
NE
Y
LPLYAF
I
NT
H
ST
M
DVS
VQ
---
D
M
R
M
-----
A
L
W
FFEYALG
-
Q
AEDIA
I
R
MR
Q
Y
T
N
EY
LDN
I
T
PP
F
TKALF
T
YV
K
E
R
KYTFCTPGHMGGTA
Y
QKSPVG
C
LFYDFFG
G
NT
L
K
A
D
V
SISVTELGSLLDHTGPH
L
EAE
E
YIAR
T
FGA
EQ
SY
I
VTNGTSTSNKIVGMY
A
AP
S
GST
L
LIDRNCHKSL
A
HLLMM
N
DV
V
PV
W
LK
PTRNA
L
GILGGIP
RG
EF
T
RD
S
I
E
E
KV
A
A
T
T
-----
Q
AQWPVHAVITNSTYDGLLYNTD
W
IK
Q
TLDV
P
S
--
IHFDSAWVPYT
H
F
H
PIY
Q
GK
S
GMSGERV
----
A
GKVIFETQSTHK
M
LAALSQAS
L
IH
I
----
KG
EY
D
EE
A
FNEA
F
MMHTTTSP
S
Y
P
IVAS
V
ETAAAM
L
R
GN
P
GKRLIN
R
S
V
ERA
L
H
FRKE
V
Q
---
RLR
E
E
---
SD
S
WFFD
I
WQP
PQ
VD
E
--------------------
A
ECW
H
V
A
PGE
Q
WHGF
--
S
D
A
D
A
N
HM
F
LDP
V
KVTILTPGM
D
E
Q
G
N
MSE
E
GIPAALVAK
F
LDE
R
GIVVEKTGPYNLLFLFSIGIDKTKA
MG
LLR
G
LT
E
FKR
S
YDLNLR
I
KNMLP
D
LY
A
EDPDFY
R
NMRIQDLAQ
G
IHKLI
RK
H
D
LP
G
LM
L
RAF
DT
LP
E
M
I
MTP
HQ
A
W
Q
RQ
I
K
G
E
VE
T
I
A
LE
Q
LVGR
V
S
ANMILPYPPGVPLLMPGEM
L
TEESR
T
VL
D
FL
L
MLCS
V
G
Q
HYPGFETDIHGA
KQDE
DG
V
Y
R
V
R
VLKMAG
fig|749545.3.peg.2439
Escherichia coli MS 182-1 (14-723/728)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
AEDIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DL
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|749545.3.peg.2438
Escherichia coli MS 182-1 (1-710/715)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
AEDIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DL
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|1040638.4.peg.1180
Escherichia coli O104:H4 str. LB226692 (1-710/715)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
AEDIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|216592.1.peg.2438
Escherichia coli 042 (14-723/728)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
AEDIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|358709.5.peg.1883
Escherichia coli 101-1 (1-710/715)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
AEDIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|562.371.peg.3652
Escherichia coli 1044A (14-723/728)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
AEDIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|562.371.peg.3651
Escherichia coli 1044A (1-710/715)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
AEDIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|562.373.peg.5751
Escherichia coli 1125A (14-723/728)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
AEDIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|562.373.peg.5752
Escherichia coli 1125A (1-710/715)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
AEDIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|562.372.peg.3406
Escherichia coli 1212A (14-723/728)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
AEDIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|562.372.peg.3407
Escherichia coli 1212A (1-710/715)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
AEDIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|670888.3.peg.4602
Escherichia coli 1827-70 (1-710/715)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
AEDIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|562.374.peg.2741
Escherichia coli 536A (14-723/728)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
AEDIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|562.374.peg.2742
Escherichia coli 536A (1-710/715)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
AEDIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|585055.6.peg.4648
Escherichia coli 55989 (1-710/715)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
AEDIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|585055.8.peg.4653
Escherichia coli 55989 (1-710/715)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
AEDIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|481805.3.peg.4184
Escherichia coli ATCC 8739 (1-710/715)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
AEDIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|481805.6.peg.4171
Escherichia coli ATCC 8739 (1-710/715)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
AEDIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|413997.3.peg.4223
Escherichia coli B str. REL606 (1-710/715)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
AEDIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|550672.3.peg.4482
Escherichia coli B088 (1-710/715)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
AEDIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|344601.3.peg.1165
Escherichia coli B171 (1-710/715)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
AEDIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|344601.5.peg.1229
Escherichia coli B171 (1-710/715)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
AEDIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|550676.3.peg.4407
Escherichia coli B185 (1-710/715)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
AEDIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|340184.3.peg.699
Escherichia coli B7A (1-710/715)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
AEDIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|340184.6.peg.729
Escherichia coli B7A (1-710/715)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
AEDIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|511693.5.peg.4244
Escherichia coli BL21 (1-710/715)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
AEDIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|469008.4.peg.4046
Escherichia coli BL21(DE3) (1-710/715)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
AEDIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|595496.3.peg.4207
Escherichia coli BW2952 (1-710/715)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
AEDIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|536056.3.peg.4099
Escherichia coli DH1 (1-710/715)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
AEDIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|340185.3.peg.1425
Escherichia coli E22 (1-710/715)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
AEDIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|340185.4.peg.1509
Escherichia coli E22 (1-710/715)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
AEDIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|331111.12.peg.4895
Escherichia coli E24377A (1-710/715)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
AEDIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|331111.3.peg.2285
Escherichia coli E24377A (1-710/715)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
AEDIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|562.375.peg.2943
Escherichia coli EC4100B (14-723/728)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
AEDIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|562.375.peg.2944
Escherichia coli EC4100B (1-710/715)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
AEDIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|316401.4.peg.5049
Escherichia coli ETEC H10407 (14-723/728)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
AEDIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|316401.4.peg.5048
Escherichia coli ETEC H10407 (1-710/715)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
AEDIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|656379.3.peg.506
Escherichia coli FVEC1302 (1-710/715)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
AEDIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|656380.3.peg.498
Escherichia coli FVEC1412 (1-710/715)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
AEDIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|656408.3.peg.4632
Escherichia coli H591 (14-723/728)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
AEDIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|656408.3.peg.4631
Escherichia coli H591 (1-710/715)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
AEDIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|656414.3.peg.4694
Escherichia coli H736 (14-723/728)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
AEDIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|656414.3.peg.4693
Escherichia coli H736 (1-710/715)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
AEDIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|331112.3.peg.4086
Escherichia coli HS (1-710/715)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
AEDIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|331112.6.peg.4261
Escherichia coli HS (1-710/715)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
AEDIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|585034.4.peg.4240
Escherichia coli IAI1 (1-710/715)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
AEDIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|585034.5.peg.4235
Escherichia coli IAI1 (1-710/715)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
AEDIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|83333.1.peg.4043
Escherichia coli K12 (1-710/715)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
AEDIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|595495.4.peg.4105
Escherichia coli KO11 (14-723/728)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
AEDIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|595495.4.peg.4106
Escherichia coli KO11 (1-710/715)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
AEDIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|656419.3.peg.5381
Escherichia coli M718 (14-723/728)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
AEDIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|656419.3.peg.5380
Escherichia coli M718 (1-710/715)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
AEDIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|679207.4.peg.3022
Escherichia coli MS 107-1 (14-723/728)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
AEDIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|679207.4.peg.3021
Escherichia coli MS 107-1 (1-710/715)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
AEDIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|749537.3.peg.4273
Escherichia coli MS 115-1 (14-723/728)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
AEDIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|749537.3.peg.4274
Escherichia coli MS 115-1 (1-710/715)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
AEDIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|749538.3.peg.1233
Escherichia coli MS 116-1 (1-710/715)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
AEDIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|679206.4.peg.994
Escherichia coli MS 119-7 (14-723/728)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
AEDIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|679206.4.peg.993
Escherichia coli MS 119-7 (1-710/715)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
AEDIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|679205.4.peg.4510
Escherichia coli MS 124-1 (14-723/728)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
AEDIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|679205.4.peg.4509
Escherichia coli MS 124-1 (1-710/715)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
AEDIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|679204.3.peg.3945
Escherichia coli MS 145-7 (14-723/728)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
AEDIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|679204.3.peg.3946
Escherichia coli MS 145-7 (1-710/715)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
AEDIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|749540.3.peg.1321
Escherichia coli MS 146-1 (1-710/715)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
AEDIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|749544.3.peg.117
Escherichia coli MS 175-1 (14-723/728)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
AEDIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|749544.3.peg.116
Escherichia coli MS 175-1 (1-710/715)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
AEDIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|749548.3.peg.3677
Escherichia coli MS 196-1 (1-710/715)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
AEDIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|749549.3.peg.1664
Escherichia coli MS 198-1 (14-723/728)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
AEDIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|749549.3.peg.1663
Escherichia coli MS 198-1 (1-710/715)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
AEDIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|749531.3.peg.2290
Escherichia coli MS 69-1 (1-710/715)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
AEDIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|749532.3.peg.4535
Escherichia coli MS 78-1 (14-723/728)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
AEDIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|749532.3.peg.4536
Escherichia coli MS 78-1 (1-710/715)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
AEDIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|749533.3.peg.4400
Escherichia coli MS 84-1 (14-723/728)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
AEDIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|749533.3.peg.4399
Escherichia coli MS 84-1 (1-710/715)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
AEDIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|585395.4.peg.5129
Escherichia coli O103:H2 str. 12009 (1-710/715)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
AEDIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|83334.1.peg.5091
Escherichia coli O157:H7 (1-710/715)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
AEDIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|155864.1.peg.5073
Escherichia coli O157:H7 EDL933 (1-710/715)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
AEDIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|155864.8.peg.5056
Escherichia coli O157:H7 EDL933 (1-710/715)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
AEDIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|444454.5.peg.4196
Escherichia coli O157:H7 str. EC4024 (1-710/715)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
AEDIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|444449.5.peg.3650
Escherichia coli O157:H7 str. EC4042 (1-710/715)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
AEDIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|444448.5.peg.2408
Escherichia coli O157:H7 str. EC4045 (1-710/715)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
AEDIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|444453.5.peg.2045
Escherichia coli O157:H7 str. EC4076 (1-710/715)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
AEDIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|444452.5.peg.1119
Escherichia coli O157:H7 str. EC4113 (1-710/715)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
AEDIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|444450.8.peg.5486
Escherichia coli O157:H7 str. EC4115 (1-710/715)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
AEDIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|444451.5.peg.2149
Escherichia coli O157:H7 str. EC4196 (1-710/715)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
AEDIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|444447.5.peg.2574
Escherichia coli O157:H7 str. EC4206 (1-710/715)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
AEDIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|478004.5.peg.2097
Escherichia coli O157:H7 str. EC4401 (1-710/715)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
AEDIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|478005.5.peg.626
Escherichia coli O157:H7 str. EC4486 (1-710/715)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
AEDIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|478006.5.peg.1511
Escherichia coli O157:H7 str. EC4501 (1-710/715)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
AEDIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|478007.5.peg.1026
Escherichia coli O157:H7 str. EC508 (1-710/715)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
AEDIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|478008.5.peg.159
Escherichia coli O157:H7 str. EC869 (1-710/715)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
AEDIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|637388.3.peg.2372
Escherichia coli O157:H7 str. FRIK2000 (1-710/715)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
AEDIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|570506.3.peg.1351
Escherichia coli O157:H7 str. FRIK966 (1-710/715)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
AEDIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|386585.9.peg.5344
Escherichia coli O157:H7 str. Sakai (1-710/715)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
AEDIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|544404.4.peg.5298
Escherichia coli O157:H7 str. TW14359 (1-710/715)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
AEDIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|502346.5.peg.1524
Escherichia coli O157:H7 str. TW14588 (1-710/715)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
AEDIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|573235.3.peg.5415
Escherichia coli O26:H11 str. 11368 (1-710/715)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
AEDIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|409438.11.peg.4613
Escherichia coli SE11 (1-710/715)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
AEDIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|439855.10.peg.4710
Escherichia coli SMS-3-5 (1-710/715)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
AEDIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|656437.3.peg.4644
Escherichia coli TA143 (14-723/728)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
AEDIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|656437.3.peg.4643
Escherichia coli TA143 (1-710/715)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
AEDIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|656443.3.peg.5120
Escherichia coli TA271 (14-723/728)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
AEDIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|656443.3.peg.5119
Escherichia coli TA271 (1-710/715)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
AEDIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|656444.3.peg.5593
Escherichia coli TA280 (14-723/728)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
AEDIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|656444.3.peg.5592
Escherichia coli TA280 (1-710/715)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
AEDIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|585056.7.peg.4829
Escherichia coli UMN026 (1-710/715)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
AEDIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|566546.3.peg.2175
Escherichia coli W (14-723/728)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
AEDIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|566546.3.peg.2176
Escherichia coli W (1-710/715)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
AEDIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|566546.4.peg.4429
Escherichia coli W (1-710/715)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
AEDIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|316407.3.peg.3969
Escherichia coli W3110 (1-710/715)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
AEDIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|316385.7.peg.4367
Escherichia coli str. K-12 substr. DH10B (1-710/715)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
AEDIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|511145.12.peg.4263
Escherichia coli str. K-12 substr. MG1655 (1-710/715)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
AEDIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|511145.6.peg.4242
Escherichia coli str. K-12 substr. MG1655 (1-710/715)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
AEDIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|656417.3.peg.5231
Escherichia coli M605 (14-723/728)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
A
D
DIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
A
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|656417.3.peg.5230
Escherichia coli M605 (1-710/715)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
A
D
DIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
A
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|340186.3.peg.1057
Escherichia coli E110019 (1-710/715)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
AEDIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
N
VLK
fig|340186.5.peg.1099
Escherichia coli E110019 (1-710/715)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
AEDIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
N
VLK
fig|670897.3.peg.1449
Escherichia coli 2362-75 (1-710/715)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
A
D
DIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|655817.3.peg.4884
Escherichia coli ABU 83972 (14-723/728)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
A
D
DIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|655817.3.peg.4883
Escherichia coli ABU 83972 (1-710/715)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
A
D
DIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|405955.13.peg.4636
Escherichia coli APEC O1 (1-710/715)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
A
D
DIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|405955.9.peg.3918
Escherichia coli APEC O1 (14-723/728)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
A
D
DIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|199310.1.peg.5031
Escherichia coli CFT073 (3-712/717)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
A
D
DIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|199310.4.peg.4825
Escherichia coli CFT073 (1-710/715)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
A
D
DIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|216593.1.peg.3871
Escherichia coli E2348/69 (14-723/728)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
A
D
DIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|340197.3.peg.3482
Escherichia coli F11 (1-710/715)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
A
D
DIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|340197.5.peg.3650
Escherichia coli F11 (1-710/715)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
A
D
DIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|656393.3.peg.250
Escherichia coli H299 (14-723/728)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
A
D
DIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|656393.3.peg.249
Escherichia coli H299 (1-710/715)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
A
D
DIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|585057.4.peg.4698
Escherichia coli IAI39 (1-710/715)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
A
D
DIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|585057.6.peg.4706
Escherichia coli IAI39 (1-710/715)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
A
D
DIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|714962.3.peg.4674
Escherichia coli IHE3034 (1-710/715)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
A
D
DIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|749550.3.peg.4454
Escherichia coli MS 200-1 (1-710/715)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
A
D
DIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|749528.3.peg.3721
Escherichia coli MS 45-1 (14-723/728)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
A
D
DIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|749528.3.peg.3722
Escherichia coli MS 45-1 (1-710/715)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
A
D
DIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|753642.3.peg.3999
Escherichia coli NC101 (14-723/728)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
A
D
DIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|753642.3.peg.4000
Escherichia coli NC101 (1-710/715)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
A
D
DIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|574521.7.peg.4560
Escherichia coli O127:H6 str. E2348/69 (1-710/715)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
A
D
DIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|685038.3.peg.4235
Escherichia coli O83:H1 str. NRG 857C (1-710/715)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
A
D
DIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|585035.6.peg.4534
Escherichia coli S88 (1-710/715)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
A
D
DIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|431946.3.peg.4183
Escherichia coli SE15 (1-710/715)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
A
D
DIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|656440.3.peg.4708
Escherichia coli TA206 (14-723/728)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
A
D
DIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|656440.3.peg.4707
Escherichia coli TA206 (1-710/715)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
A
D
DIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|869729.3.peg.4488
Escherichia coli UM146 (14-723/728)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
A
D
DIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|869729.3.peg.4487
Escherichia coli UM146 (1-710/715)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
A
D
DIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|364106.7.peg.4608
Escherichia coli UTI89 (1-710/715)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
A
D
DIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|364106.8.peg.4607
Escherichia coli UTI89 (1-710/715)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
A
D
DIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|562.376.peg.1808
Escherichia coli WV_060327 (14-723/728)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
A
D
DIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|562.376.peg.1807
Escherichia coli WV_060327 (1-710/715)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
A
D
DIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|585397.7.peg.4853
Escherichia coli ED1a (1-710/715)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
A
D
DIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
P
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|585397.9.peg.4853
Escherichia coli ED1a (1-710/715)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
A
D
DIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
P
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|749527.3.peg.5053
Escherichia coli MS 21-1 (14-723/728)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
AEDIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVH
T
VITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|749527.3.peg.5052
Escherichia coli MS 21-1 (1-710/715)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
AEDIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVH
T
VITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|344610.3.peg.1408
Escherichia coli 53638 (1-710/715)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
F
ENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
AEDIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YT
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|344610.7.peg.1996
Escherichia coli 53638 (1-710/715)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
F
ENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
AEDIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YT
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|362663.8.peg.4410
Escherichia coli 536 (1-710/715)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
A
D
DIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSL
V
DH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|362663.9.peg.4426
Escherichia coli 536 (1-710/715)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
A
D
DIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSL
V
DH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|749546.3.peg.1595
Escherichia coli MS 185-1 (14-723/728)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
A
D
DIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NE
K
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|749546.3.peg.1596
Escherichia coli MS 185-1 (1-710/715)
MNVIAILNHMGVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
A
D
DIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NE
K
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|216592.3.peg.4669
Escherichia coli 042 (2-701/706)
GVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
AEDIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|550677.3.peg.128
Escherichia coli B354 (2-701/706)
GVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
AEDIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|701177.3.peg.4964
Escherichia coli O55:H7 str. CB9615 (2-701/706)
GVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
AEDIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|316385.5.peg.4277
Escherichia coli str. K-12 substr. DH10B (2-701/706)
GVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
AEDIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|525281.3.peg.1736
Escherichia coli 83972 (2-701/706)
GVYFKEEPIREL
HR
AL
ER
L
NFQI
V
Y
P
N
D
R
DDLLK
L
IENN
A
R
L
CGVIFDWD
K
YNL
E
LC
E
EI
S
KM
-------
NENLPLYAF
A
NT
Y
STLDVS
LN
---
DLR
L
-----
Q
I
S
FFEYALG
-
A
A
D
DIA
N
K
IK
Q
T
T
D
EY
INT
ILPPLTKALFKYV
R
E
G
KYTFCTPGHMGGTAFQKSPVG
S
LFYDFFG
P
NT
M
KSDISISV
S
ELGSLLDH
S
GPH
K
EAEQYIARVF
N
ADRSY
M
VTNGTST
A
NKIVGMY
S
AP
A
GSTILIDRNCHKSL
T
HL
M
MMSDV
T
P
I
Y
FR
PTRNAYGILGGIP
QS
EFQ
HA
TI
A
K
R
V
K
ETP
-----
N
A
T
WPVHAVITNSTYDGLLYNTD
F
IKKTLDV
K
S
--
IHFDSAWVPYT
N
FSPIY
E
GK
C
GMSG
G
RV
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DV
NEE
T
FNEAYMMHTTTSP
H
Y
G
IVAS
T
ETAAAMM
K
GN
A
GKRLIN
G
SIERAI
K
FRKEI
K
---
RLR
T
E
---
SDGWFFD
V
WQP
DH
I
D
T
--------------------
T
ECWPL
R
SDS
T
WHGF
--
K
N
ID
N
EHM
Y
LDPIKVT
L
LTPGM
E
K
DG
T
MS
D
F
GIPA
SI
VAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKA
LS
LLR
A
LT
D
FKR
A
F
DLNLRVKNMLP
S
LY
R
EDP
E
FY
E
NMRIQ
E
LAQ
N
IHKLI
VH
HNLP
D
LM
Y
RAF
EV
LP
T
M
V
MTP
YA
AFQ
KE
L
H
G
M
T
E
E
V
Y
L
D
E
M
VGRINANMILPYPPGVPL
V
MPGEM
I
TEESRPVL
E
FL
Q
MLC
E
I
G
A
HYPGFETDIHGA
YRQA
DG
R
Y
T
V
K
VLK
fig|362663.8.peg.323
Escherichia coli 536 (11-707/708)
F
DN
K
Y
V
A
E
I
IS
H
L
HT
K
NF
GTE
L
A
G
C
S
E
K
I
ET
I
I
R
NN
A
RI
AA
V
L
L
D
L
D
D
S
N
-
D
I
L
D
K
I
R
M
L
-------
NE
H
LP
VFLL
-
--
-
K
T
D
DV
A
IK
---
KFC
F
DSFDG
N
V
H
LI
D
CC
L
Y
-
S
V
D
E
I
V
N
K
IQ
K
I
I
N
D
Y
IDA
ILPPLTKALF
N
YV
K
E
G
KYTFCTPGHMGGTA
Y
QKSP
A
G
S
LFYDFFG
E
NT
M
KSDIS
V
SV
G
ELGSLLDH
S
GPH
S
EAE
K
YIA
E
T
F
N
ADRSY
I
VTNGTST
A
NKIVG
Q
F
S
V
P
A
G
C
T
A
LIDRNCHKSL
T
H
M
LMMSD
I
I
P
I
Y
LK
PTRNAYGILGGIP
RT
EF
S
SD
S
I
K
Q
K
M
A
V
TP
-----
G
A
T
WPVHAVITNSTYDGL
F
YNTD
W
IK
E
H
LDV
K
S
--
IHFDSAWVPYT
N
FSPIY
S
GK
T
GM
G
G
K
R
I
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DI
NEE
T
FNEAYMM
Q
T
S
TSP
H
Y
G
IVAS
T
E
M
AAAMM
K
GN
P
GKRLI
Q
E
S
M
ERA
L
A
FRKEI
Q
---
ARF
E
N
---
SD
T
WFF
K
V
WQP
EN
I
N
E
--------------------
V
D
CWPL
D
KN
D
Q
WHGF
--
KDID
Q
EHM
Y
LDPIKVT
L
LTPG
L
D
K
Y
G
K
I
E
E
Q
GIPAALV
S
K
F
LD
D
R
GI
I
VEKTGPYN
I
LFLFSIGID
D
TKA
LS
LL
H
G
L
Y
E
FK
E
R
YD
R
N
EL
VK
DI
LP
G
IW
A
E
S
P
A
FY
N
NMRIQ
E
LAQ
G
IH
N
LI
RK
HNLP
E
LM
F
RAF
DV
LP
E
M
V
M
K
P
QQ
AFQ
AE
L
R
G
E
T
E
E
C
F
I
E
D
LVG
K
INANMILPYPPGVPL
VL
PGEM
I
TE
S
N
RPVL
E
FL
L
MLC
E
I
G
N
HYPGFETDIHG
L
YRKA
D
N
R
Y
T
A
K
V
I
K
fig|362663.9.peg.322
Escherichia coli 536 (11-707/708)
F
DN
K
Y
V
A
E
I
IS
H
L
HT
K
NF
GTE
L
A
G
C
S
E
K
I
ET
I
I
R
NN
A
RI
AA
V
L
L
D
L
D
D
S
N
-
D
I
L
D
K
I
R
M
L
-------
NE
H
LP
VFLL
-
--
-
K
T
D
DV
A
IK
---
KFC
F
DSFDG
N
V
H
LI
D
CC
L
Y
-
S
V
D
E
I
V
N
K
IQ
K
I
I
N
D
Y
IDA
ILPPLTKALF
N
YV
K
E
G
KYTFCTPGHMGGTA
Y
QKSP
A
G
S
LFYDFFG
E
NT
M
KSDIS
V
SV
G
ELGSLLDH
S
GPH
S
EAE
K
YIA
E
T
F
N
ADRSY
I
VTNGTST
A
NKIVG
Q
F
S
V
P
A
G
C
T
A
LIDRNCHKSL
T
H
M
LMMSD
I
I
P
I
Y
LK
PTRNAYGILGGIP
RT
EF
S
SD
S
I
K
Q
K
M
A
V
TP
-----
G
A
T
WPVHAVITNSTYDGL
F
YNTD
W
IK
E
H
LDV
K
S
--
IHFDSAWVPYT
N
FSPIY
S
GK
T
GM
G
G
K
R
I
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DI
NEE
T
FNEAYMM
Q
T
S
TSP
H
Y
G
IVAS
T
E
M
AAAMM
K
GN
P
GKRLI
Q
E
S
M
ERA
L
A
FRKEI
Q
---
ARF
E
N
---
SD
T
WFF
K
V
WQP
EN
I
N
E
--------------------
V
D
CWPL
D
KN
D
Q
WHGF
--
KDID
Q
EHM
Y
LDPIKVT
L
LTPG
L
D
K
Y
G
K
I
E
E
Q
GIPAALV
S
K
F
LD
D
R
GI
I
VEKTGPYN
I
LFLFSIGID
D
TKA
LS
LL
H
G
L
Y
E
FK
E
R
YD
R
N
EL
VK
DI
LP
G
IW
A
E
S
P
A
FY
N
NMRIQ
E
LAQ
G
IH
N
LI
RK
HNLP
E
LM
F
RAF
DV
LP
E
M
V
M
K
P
QQ
AFQ
AE
L
R
G
E
T
E
E
C
F
I
E
D
LVG
K
INANMILPYPPGVPL
VL
PGEM
I
TE
S
N
RPVL
E
FL
L
MLC
E
I
G
N
HYPGFETDIHG
L
YRKA
D
N
R
Y
T
A
K
V
I
K
fig|340197.3.peg.1379
Escherichia coli F11 (11-707/708)
F
DN
K
Y
V
A
E
I
IS
H
L
HT
K
NF
GTE
L
A
G
C
S
E
K
I
ET
I
I
R
NN
A
RI
AA
V
L
L
D
L
D
D
S
N
-
D
I
L
D
K
I
R
M
L
-------
NE
H
LP
VFLL
-
--
-
K
T
D
DV
A
IK
---
KFC
F
DSFDG
N
V
H
LI
D
CC
L
Y
-
S
V
D
E
I
V
N
K
IQ
K
I
I
N
D
Y
IDA
ILPPLTKALF
N
YV
K
E
G
KYTFCTPGHMGGTA
Y
QKSP
A
G
S
LFYDFFG
E
NT
M
KSDIS
V
SV
G
ELGSLLDH
S
GPH
S
EAE
K
YIA
E
T
F
N
ADRSY
I
VTNGTST
A
NKIVG
Q
F
S
V
P
A
G
C
T
A
LIDRNCHKSL
T
H
M
LMMSD
I
I
P
I
Y
LK
PTRNAYGILGGIP
RT
EF
S
SD
S
I
K
Q
K
M
A
V
TP
-----
G
A
T
WPVHAVITNSTYDGL
F
YNTD
W
IK
E
H
LDV
K
S
--
IHFDSAWVPYT
N
FSPIY
S
GK
T
GM
G
G
K
R
I
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DI
NEE
T
FNEAYMM
Q
T
S
TSP
H
Y
G
IVAS
T
E
M
AAAMM
K
GN
P
GKRLI
Q
E
S
M
ERA
L
A
FRKEI
Q
---
ARF
E
N
---
SD
T
WFF
K
V
WQP
EN
I
N
E
--------------------
V
D
CWPL
D
KN
D
Q
WHGF
--
KDID
Q
EHM
Y
LDPIKVT
L
LTPG
L
D
K
Y
G
K
I
E
E
Q
GIPAALV
S
K
F
LD
D
R
GI
I
VEKTGPYN
I
LFLFSIGID
D
TKA
LS
LL
H
G
L
Y
E
FK
E
R
YD
R
N
EL
VK
DI
LP
G
IW
A
E
S
P
A
FY
N
NMRIQ
E
LAQ
G
IH
N
LI
RK
HNLP
E
LM
F
RAF
DV
LP
E
M
V
M
K
P
QQ
AFQ
AE
L
R
G
E
T
E
E
C
F
I
E
D
LVG
K
INANMILPYPPGVPL
VL
PGEM
I
TE
S
N
RPVL
E
FL
L
MLC
E
I
G
N
HYPGFETDIHG
L
YRKA
D
N
R
Y
T
A
K
V
I
K
fig|340197.5.peg.1458
Escherichia coli F11 (11-707/708)
F
DN
K
Y
V
A
E
I
IS
H
L
HT
K
NF
GTE
L
A
G
C
S
E
K
I
ET
I
I
R
NN
A
RI
AA
V
L
L
D
L
D
D
S
N
-
D
I
L
D
K
I
R
M
L
-------
NE
H
LP
VFLL
-
--
-
K
T
D
DV
A
IK
---
KFC
F
DSFDG
N
V
H
LI
D
CC
L
Y
-
S
V
D
E
I
V
N
K
IQ
K
I
I
N
D
Y
IDA
ILPPLTKALF
N
YV
K
E
G
KYTFCTPGHMGGTA
Y
QKSP
A
G
S
LFYDFFG
E
NT
M
KSDIS
V
SV
G
ELGSLLDH
S
GPH
S
EAE
K
YIA
E
T
F
N
ADRSY
I
VTNGTST
A
NKIVG
Q
F
S
V
P
A
G
C
T
A
LIDRNCHKSL
T
H
M
LMMSD
I
I
P
I
Y
LK
PTRNAYGILGGIP
RT
EF
S
SD
S
I
K
Q
K
M
A
V
TP
-----
G
A
T
WPVHAVITNSTYDGL
F
YNTD
W
IK
E
H
LDV
K
S
--
IHFDSAWVPYT
N
FSPIY
S
GK
T
GM
G
G
K
R
I
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DI
NEE
T
FNEAYMM
Q
T
S
TSP
H
Y
G
IVAS
T
E
M
AAAMM
K
GN
P
GKRLI
Q
E
S
M
ERA
L
A
FRKEI
Q
---
ARF
E
N
---
SD
T
WFF
K
V
WQP
EN
I
N
E
--------------------
V
D
CWPL
D
KN
D
Q
WHGF
--
KDID
Q
EHM
Y
LDPIKVT
L
LTPG
L
D
K
Y
G
K
I
E
E
Q
GIPAALV
S
K
F
LD
D
R
GI
I
VEKTGPYN
I
LFLFSIGID
D
TKA
LS
LL
H
G
L
Y
E
FK
E
R
YD
R
N
EL
VK
DI
LP
G
IW
A
E
S
P
A
FY
N
NMRIQ
E
LAQ
G
IH
N
LI
RK
HNLP
E
LM
F
RAF
DV
LP
E
M
V
M
K
P
QQ
AFQ
AE
L
R
G
E
T
E
E
C
F
I
E
D
LVG
K
INANMILPYPPGVPL
VL
PGEM
I
TE
S
N
RPVL
E
FL
L
MLC
E
I
G
N
HYPGFETDIHG
L
YRKA
D
N
R
Y
T
A
K
V
I
K
fig|749550.3.peg.3426
Escherichia coli MS 200-1 (11-707/708)
F
DN
K
Y
V
A
E
I
IS
H
L
HT
K
NF
GTE
L
A
G
C
S
E
K
I
ET
I
I
R
NN
A
RI
AA
V
L
L
D
L
D
D
S
N
-
D
I
L
D
K
I
R
M
L
-------
NE
H
LP
VFLL
-
--
-
K
T
D
DV
A
IK
---
KFC
F
DSFDG
N
V
H
LI
D
CC
L
Y
-
S
V
D
E
I
V
N
K
IQ
K
I
I
N
D
Y
IDA
ILPPLTKALF
N
YV
K
E
G
KYTFCTPGHMGGTA
Y
QKSP
A
G
S
LFYDFFG
E
NT
M
KSDIS
V
SV
G
ELGSLLDH
S
GPH
S
EAE
K
YIA
E
T
F
N
ADRSY
I
VTNGTST
A
NKIVG
Q
F
S
V
P
A
G
C
T
A
LIDRNCHKSL
T
H
M
LMMSD
I
I
P
I
Y
LK
PTRNAYGILGGIP
RT
EF
S
SD
S
I
K
Q
K
M
A
V
TP
-----
G
A
T
WPVHAVITNSTYDGL
F
YNTD
W
IK
E
H
LDV
K
S
--
IHFDSAWVPYT
N
FSPIY
S
GK
T
GM
G
G
K
R
I
----
E
GKVI
Y
ETQSTHKLLAA
F
SQAS
M
IHV
----
KG
DI
NEE
T
FNEAYMM
Q
T
S
TSP
H
Y
G
IVAS
T
E
M
AAAMM
K
GN
P
GK
C
LI
Q
E
S
M
ERA
L
A
FRKEI
Q
---
ARF
E
N
---
SD
T
WFF
K
V
WQP
EN
I
N
E
--------------------
V
D
CWPL
D
KN
D
Q
WHGF
--
KDID
Q
EHM
Y
LDPIKVT
L
LTPG
L
D
K
Y
G
K
I
E
E
Q
GIPAALV
S
K
F
LD
D
R
GI
I
VEKTGPYN
I
LFLFSIGID
D
TKA
LS
LL
H
G
L
Y
E
FK
E
R
YD
R
N
EL
VK
DI
LP
G
IW
A
E
S
P
A
FY
N
NMRIQ
E
LAQ
G
IH
N
LI
RK
HNLP
E
LM
F
RAF
DV
LP
E
M
V
M
K
P
QQ
AFQ
AE
L
R
G
E
T
E
E
C
F
I
E
D
LVG
K
INANMILPYPPGVPL
VL
PGEM
I
TE
S
N
RPVL
E
FL
L
MLC
E
I
G
N
HYPGFETDIHG
L
YRKA
D
N
R
Y
T
A
K
V
I
K
fig|585397.7.peg.3444
Escherichia coli ED1a (25-761/789)
L
E
EL
QT
E
L
AE
R
G
F
K
I
H
I
T
H
Q
I
S
D
G
LK
I
IE
K
S
P
Q
YS
G
I
G
F
Y
W
E
P
D
N
P
TFA
E
E
L
Q
HF
I
SIFRK
R
N
ATT
PL
II
F
S
EQ
N
----
IT
DR
IPL
D
V
L
K
-----
E
V
S
E
Y
V
Y
LFSE
S
A
A
F
T
A
N
R
LY
S
L
V
H
R
Y
ADK
L
LPP
Y
F
K
T
L
KD
F
T
E
D
G
D
Y
Y
W
DC
PGHMGG
M
A
Y
L
K
H
PVG
I
E
F
I
N
FFG
E
N
M
M
R
A
DI
G
VA
TA
E
M
G
DY
L
I
H
A
GP
P
K
K
S
E
E
I
A
AR
L
FG
S
D
W
TF
Y
G
V
S
G
S
S
G
SN
R
IV
A
QA
A
VG
A
DEIA
I
IDRNCHKSL
N
H
G
L
T
L
S
Q
A
R
PVY
LK
PTRNA
W
G
L
I
G
P
IP
TG
RL
K
KA
S
I
D
AL
V
A
N
S
R
L
ASGA
V
S
Q
S
P
SY
AV
V
TN
C
TYDG
F
C
YN
V
N
D
V
V
R
H
L
GE
S
A
P
R
IHFD
E
AW
Y
A
Y
A
R
F
H
P
L
Y
Q
S
R
Y
A
M
DA
E
ET
P
---
N
R
PT
L
F
A
V
QSTHK
M
L
P
S
LS
M
AS
M
IHV
KKSD
R
A
PL
N
F
D
D
FN
D
A
F
MMH
G
TTSP
Y
Y
P
I
I
AS
I
DV
A
VS
MM
E
G
E
S
G
Y
S
L
V
Q
E
SIE
E
AI
A
FRK
A
V
V
SVK
R
QL
Q
E
QEGG
D
A
WFFD
V
L
QP
TE
V
Q
D
SDS
G
QR
Y
S
F
EE
AP
VS
LL
SHS
A
D
CW
S
L
R
S
GE
R
WHGF
ADD
D
L
V
E
T
N
S
M
LDP
V
KVT
L
TC
PG
I
G
PK
G
E
YQ
K
N
GIP
GY
L
L
T
RF
LD
D
R
R
I
E
I
A
R
TG
D
Y
T
V
L
I
LFS
V
GI
T
K
G
K
W
GT
L
I
E
S
L
L
A
FK
K
H
YD
N
D
DLAT
D
A
I
P
S
L
K
A
HS
P
H-
Y
D
T
L
T
LK
E
L
C
Q
I
M
H
E
K
M
DE
LE
L
M
S
H
I
N
D
A
V
NT
D
P
E
P
V
MTP
AE
A
Y
Q
KV
V
R
Y
K
T
E
H
I
R
L
D
D
FS
GRI
A
A
S
M
LV
PYPPG
I
P
V
LMPGE
R
M
P
Q
G
N
K
G
II
G
Y
L
R
A
L
QE
F
D
K
Q
F
PGFE
HE
I
Q
G
V
NVDE
DG
D
F
W
V
R
A
I
fig|585397.9.peg.3440
Escherichia coli ED1a (25-761/789)
L
E
EL
QT
E
L
AE
R
G
F
K
I
H
I
T
H
Q
I
S
D
G
LK
I
IE
K
S
P
Q
YS
G
I
G
F
Y
W
E
P
D
N
P
TFA
E
E
L
Q
HF
I
SIFRK
R
N
ATT
PL
II
F
S
EQ
N
----
IT
DR
IPL
D
V
L
K
-----
E
V
S
E
Y
V
Y
LFSE
S
A
A
F
T
A
N
R
LY
S
L
V
H
R
Y
ADK
L
LPP
Y
F
K
T
L
KD
F
T
E
D
G
D
Y
Y
W
DC
PGHMGG
M
A
Y
L
K
H
PVG
I
E
F
I
N
FFG
E
N
M
M
R
A
DI
G
VA
TA
E
M
G
DY
L
I
H
A
GP
P
K
K
S
E
E
I
A
AR
L
FG
S
D
W
TF
Y
G
V
S
G
S
S
G
SN
R
IV
A
QA
A
VG
A
DEIA
I
IDRNCHKSL
N
H
G
L
T
L
S
Q
A
R
PVY
LK
PTRNA
W
G
L
I
G
P
IP
TG
RL
K
KA
S
I
D
AL
V
A
N
S
R
L
ASGA
V
S
Q
S
P
SY
AV
V
TN
C
TYDG
F
C
YN
V
N
D
V
V
R
H
L
GE
S
A
P
R
IHFD
E
AW
Y
A
Y
A
R
F
H
P
L
Y
Q
S
R
Y
A
M
DA
E
ET
P
---
N
R
PT
L
F
A
V
QSTHK
M
L
P
S
LS
M
AS
M
IHV
KKSD
R
A
PL
N
F
D
D
FN
D
A
F
MMH
G
TTSP
Y
Y
P
I
I
AS
I
DV
A
VS
MM
E
G
E
S
G
Y
S
L
V
Q
E
SIE
E
AI
A
FRK
A
V
V
SVK
R
QL
Q
E
QEGG
D
A
WFFD
V
L
QP
TE
V
Q
D
SDS
G
QR
Y
S
F
EE
AP
VS
LL
SHS
A
D
CW
S
L
R
S
GE
R
WHGF
ADD
D
L
V
E
T
N
S
M
LDP
V
KVT
L
TC
PG
I
G
PK
G
E
YQ
K
N
GIP
GY
L
L
T
RF
LD
D
R
R
I
E
I
A
R
TG
D
Y
T
V
L
I
LFS
V
GI
T
K
G
K
W
GT
L
I
E
S
L
L
A
FK
K
H
YD
N
D
DLAT
D
A
I
P
S
L
K
A
HS
P
H-
Y
D
T
L
T
LK
E
L
C
Q
I
M
H
E
K
M
DE
LE
L
M
S
H
I
N
D
A
V
NT
D
P
E
P
V
MTP
AE
A
Y
Q
KV
V
R
Y
K
T
E
H
I
R
L
D
D
FS
GRI
A
A
S
M
LV
PYPPG
I
P
V
LMPGE
R
M
P
Q
G
N
K
G
II
G
Y
L
R
A
L
QE
F
D
K
Q
F
PGFE
HE
I
Q
G
V
NVDE
DG
D
F
W
V
R
A
I
fig|749538.3.peg.2800
Escherichia coli MS 116-1 (25-761/789)
L
E
EL
QT
E
L
AE
R
G
F
K
I
H
I
T
H
Q
I
S
D
G
LK
I
IE
K
S
P
Q
YS
G
I
G
F
Y
W
E
P
D
N
P
TFA
E
E
L
Q
HF
I
SIFRK
R
N
ATT
PL
II
F
S
EQ
N
----
IT
DR
IPL
D
V
L
K
-----
E
V
S
E
Y
V
Y
LFSE
S
A
A
F
T
A
N
R
LY
S
L
V
H
R
Y
ADK
L
LPP
Y
F
K
T
L
KD
F
T
V
D
G
D
Y
Y
W
DC
PGHMGG
M
A
Y
L
K
H
PVG
I
E
F
I
N
FFG
E
N
M
M
R
A
DI
G
VA
TA
E
M
G
DY
L
I
H
A
GP
P
K
K
S
E
E
I
A
AR
L
FG
S
D
W
TF
Y
G
V
S
G
S
S
G
SN
R
IV
A
QA
A
VG
A
DEIA
I
IDRNCHKSL
N
H
G
L
T
L
S
Q
A
R
PVY
LK
PTRNA
W
G
L
I
G
P
IP
TG
RL
K
KA
S
I
D
AL
V
A
N
S
R
L
ASGA
V
S
Q
S
P
SY
AV
V
TN
C
TYDG
F
C
YN
V
N
D
V
V
R
H
L
GE
S
A
P
R
IHFD
E
AW
Y
A
Y
A
R
F
H
P
L
Y
Q
S
R
Y
A
M
DA
E
ET
P
---
N
R
PT
L
F
A
V
QSTHK
M
L
P
S
LS
M
AS
M
IHV
KKSD
R
A
PL
N
F
D
D
FN
D
A
F
MMH
G
TTSP
Y
Y
P
I
I
AS
I
DV
A
VS
MM
E
G
E
S
G
Y
S
L
V
Q
E
SIE
E
AI
A
FRK
A
V
V
SVK
R
QL
Q
E
QEGG
D
A
WFFD
V
L
QP
TE
V
Q
D
SDS
G
QR
Y
S
F
EE
AP
VS
LL
SHS
A
D
CW
S
L
R
S
GE
R
WHGF
ADD
D
L
V
E
T
N
S
M
LDP
V
KVT
L
TC
PG
I
G
PK
G
E
YQ
K
N
GIP
GY
L
L
T
RF
LD
D
R
R
I
E
I
A
R
TG
D
Y
T
V
L
I
LFS
V
GI
T
K
G
K
W
GT
L
I
E
S
L
L
A
FK
K
H
YD
N
D
DLAT
D
A
I
P
S
L
K
A
HS
P
H-
Y
D
T
L
T
LK
E
L
C
Q
I
M
H
E
K
M
DE
LE
L
M
S
H
I
N
D
A
V
NT
D
P
E
P
V
MTP
AE
A
Y
Q
KV
V
R
Y
K
T
E
H
I
R
L
D
D
FS
GRI
A
A
S
M
LV
PYPPG
I
P
V
LMPGE
R
M
P
Q
G
N
K
G
II
G
Y
L
R
A
L
QE
F
D
K
Q
F
PGFE
HE
I
Q
G
V
NVDE
DG
D
F
W
V
R
A
I
fig|405955.13.peg.4702
Escherichia coli APEC O1 (25-761/789)
L
E
EL
QT
E
L
AE
R
G
F
K
I
H
I
T
H
Q
I
S
D
G
LK
I
IE
K
S
P
Q
YS
G
I
G
F
Y
W
E
P
D
N
P
TFA
E
E
L
Q
HF
I
SIFRK
R
N
ATT
PL
II
F
S
EQ
N
----
IT
DR
IPL
D
V
L
K
-----
E
V
S
E
Y
V
Y
LFSE
S
A
A
F
T
A
N
R
LY
S
L
V
H
R
Y
ADK
L
LPP
Y
F
K
T
L
KD
F
T
E
D
G
D
Y
Y
W
DC
PGHMGG
M
A
Y
L
K
H
PVG
I
E
F
I
N
FFG
E
N
M
M
R
A
DI
G
VA
TA
E
M
G
DY
L
I
H
A
GP
P
K
K
S
E
E
I
A
AR
L
FG
S
D
W
TF
Y
G
V
S
G
S
S
G
SN
R
IV
A
QA
A
VG
A
DEIA
I
IDRNCHKSL
N
H
G
L
T
L
S
Q
A
R
PVY
LK
PTRNA
W
G
L
I
G
P
IP
TG
RL
K
KA
S
I
D
AL
V
A
N
S
R
L
ASGA
V
S
Q
S
P
SY
AV
V
TN
C
TYDG
F
C
YN
V
N
D
V
V
R
H
L
GE
S
A
P
R
IHFD
E
AW
Y
A
Y
A
R
F
H
P
L
Y
Q
S
R
Y
A
M
DA
E
ET
P
---
N
R
PT
L
F
A
V
QSTHK
M
L
P
S
LS
M
AS
M
IHV
KKSD
R
A
PL
N
F
D
D
FN
D
A
F
MMH
G
TTSP
Y
Y
P
I
I
AS
I
DV
A
VS
MM
E
G
E
S
G
Y
S
L
V
Q
E
SIE
E
AI
A
FRK
A
V
V
SVK
R
QL
Q
E
QEGG
D
A
WFFD
V
L
QP
TE
V
Q
D
SDS
G
QR
Y
S
F
EE
AP
VS
LL
SHS
A
D
CW
S
L
R
S
GE
R
WHGF
ADD
D
L
V
E
T
N
S
M
LDP
V
KVT
L
TC
PG
I
G
PK
G
E
YQ
K
N
GIP
GY
L
L
T
RF
LD
D
R
R
I
E
I
A
R
TG
D
Y
T
V
L
I
LFS
V
GI
T
K
G
K
W
GT
L
I
E
S
L
L
A
FK
K
H
YD
N
D
DLAT
D
A
I
P
S
L
K
A
HS
P
H-
Y
D
T
L
T
LK
E
L
C
Q
I
M
H
E
K
M
DE
LE
L
M
S
H
I
N
D
A
V
NT
D
P
E
P
V
MTP
AE
A
Y
Q
KV
V
R
Y
K
T
E
H
I
R
L
D
D
FS
GRI
A
A
S
M
LV
PYPPG
I
P
V
LMPGE
R
M
P
Q
G
N
K
G
II
G
Y
L
R
A
L
QE
F
D
K
Q
F
PGFE
HE
I
Q
G
V
NVDE
N
G
D
F
W
V
R
A
I
fig|405955.9.peg.3969
Escherichia coli APEC O1 (25-761/789)
L
E
EL
QT
E
L
AE
R
G
F
K
I
H
I
T
H
Q
I
S
D
G
LK
I
IE
K
S
P
Q
YS
G
I
G
F
Y
W
E
P
D
N
P
TFA
E
E
L
Q
HF
I
SIFRK
R
N
ATT
PL
II
F
S
EQ
N
----
IT
DR
IPL
D
V
L
K
-----
E
V
S
E
Y
V
Y
LFSE
S
A
A
F
T
A
N
R
LY
S
L
V
H
R
Y
ADK
L
LPP
Y
F
K
T
L
KD
F
T
E
D
G
D
Y
Y
W
DC
PGHMGG
M
A
Y
L
K
H
PVG
I
E
F
I
N
FFG
E
N
M
M
R
A
DI
G
VA
TA
E
M
G
DY
L
I
H
A
GP
P
K
K
S
E
E
I
A
AR
L
FG
S
D
W
TF
Y
G
V
S
G
S
S
G
SN
R
IV
A
QA
A
VG
A
DEIA
I
IDRNCHKSL
N
H
G
L
T
L
S
Q
A
R
PVY
LK
PTRNA
W
G
L
I
G
P
IP
TG
RL
K
KA
S
I
D
AL
V
A
N
S
R
L
ASGA
V
S
Q
S
P
SY
AV
V
TN
C
TYDG
F
C
YN
V
N
D
V
V
R
H
L
GE
S
A
P
R
IHFD
E
AW
Y
A
Y
A
R
F
H
P
L
Y
Q
S
R
Y
A
M
DA
E
ET
P
---
N
R
PT
L
F
A
V
QSTHK
M
L
P
S
LS
M
AS
M
IHV
KKSD
R
A
PL
N
F
D
D
FN
D
A
F
MMH
G
TTSP
Y
Y
P
I
I
AS
I
DV
A
VS
MM
E
G
E
S
G
Y
S
L
V
Q
E
SIE
E
AI
A
FRK
A
V
V
SVK
R
QL
Q
E
QEGG
D
A
WFFD
V
L
QP
TE
V
Q
D
SDS
G
QR
Y
S
F
EE
AP
VS
LL
SHS
A
D
CW
S
L
R
S
GE
R
WHGF
ADD
D
L
V
E
T
N
S
M
LDP
V
KVT
L
TC
PG
I
G
PK
G
E
YQ
K
N
GIP
GY
L
L
T
RF
LD
D
R
R
I
E
I
A
R
TG
D
Y
T
V
L
I
LFS
V
GI
T
K
G
K
W
GT
L
I
E
S
L
L
A
FK
K
H
YD
N
D
DLAT
D
A
I
P
S
L
K
A
HS
P
H-
Y
D
T
L
T
LK
E
L
C
Q
I
M
H
E
K
M
DE
LE
L
M
S
H
I
N
D
A
V
NT
D
P
E
P
V
MTP
AE
A
Y
Q
KV
V
R
Y
K
T
E
H
I
R
L
D
D
FS
GRI
A
A
S
M
LV
PYPPG
I
P
V
LMPGE
R
M
P
Q
G
N
K
G
II
G
Y
L
R
A
L
QE
F
D
K
Q
F
PGFE
HE
I
Q
G
V
NVDE
N
G
D
F
W
V
R
A
I
fig|199310.1.peg.4406
Escherichia coli CFT073 (25-761/789)
L
E
EL
QT
E
L
AE
R
G
F
K
I
H
I
T
H
Q
I
S
D
G
LK
I
IE
K
S
P
Q
YS
G
I
G
F
Y
W
E
P
D
N
P
TFA
E
E
L
Q
HF
I
SIFRK
R
N
ATT
PL
II
F
S
EQ
N
----
IT
DR
IPL
D
V
L
K
-----
E
V
S
E
Y
V
Y
LFSE
S
A
A
F
T
A
N
R
LY
S
L
V
H
R
Y
ADK
L
LPP
Y
F
K
T
L
KD
F
T
E
D
G
D
Y
Y
W
DC
PGHMGG
M
A
Y
L
K
H
PVG
I
E
F
I
N
FFG
E
N
M
M
R
A
DI
G
VA
TA
E
M
G
DY
L
I
H
A
GP
P
K
K
S
E
E
I
A
AR
L
FG
S
D
W
TF
Y
G
V
S
G
S
S
G
SN
R
IV
A
QA
A
VG
A
DEIA
I
IDRNCHKSL
N
H
G
L
T
L
S
Q
A
R
PVY
LK
PTRNA
W
G
L
I
G
P
IP
TG
RL
K
KA
S
I
D
AL
V
A
N
S
R
L
ASGA
V
S
Q
S
P
SY
AV
V
TN
C
TYDG
F
C
YN
V
N
D
V
V
R
H
L
GE
S
A
P
R
IHFD
E
AW
Y
A
Y
A
R
F
H
P
L
Y
Q
S
R
Y
A
M
DA
E
ET
P
---
N
R
PT
L
F
A
V
QSTHK
M
L
P
S
LS
M
AS
M
IHV
KKSD
R
A
PL
N
F
D
D
FN
D
A
F
MMH
G
TTSP
Y
Y
P
I
I
AS
I
DV
A
VS
MM
E
G
E
S
G
Y
S
L
V
Q
E
SIE
E
AI
A
FRK
A
V
V
SVK
R
QL
Q
E
QEGG
D
A
WFFD
V
L
QP
TE
V
Q
D
SDS
G
QR
Y
S
F
EE
AP
VS
LL
SHS
A
D
CW
S
L
R
S
GE
R
WHGF
ADD
D
L
V
E
T
N
S
M
LDP
V
KVT
L
TC
PG
I
G
PK
G
E
YQ
K
N
GIP
GY
L
L
T
RF
LD
D
R
R
I
E
I
A
R
TG
D
Y
T
V
L
I
LFS
V
GI
T
K
G
K
W
GT
L
I
E
S
L
L
A
FK
K
H
YD
N
D
DLAT
D
A
I
P
S
L
K
A
HS
P
H-
Y
D
T
L
T
LK
E
L
C
Q
I
M
H
E
K
M
DE
LE
L
M
S
H
I
N
D
A
V
NT
D
P
E
P
V
MTP
AE
A
Y
Q
KV
V
R
Y
K
T
E
H
I
R
L
D
D
FS
GRI
A
A
S
M
LV
PYPPG
I
P
V
LMPGE
R
M
P
Q
G
N
K
G
II
G
Y
L
R
A
L
QE
F
D
K
Q
F
PGFE
HE
I
Q
G
V
NVDE
N
G
D
F
W
V
R
A
I
fig|199310.4.peg.4228
Escherichia coli CFT073 (25-761/789)
L
E
EL
QT
E
L
AE
R
G
F
K
I
H
I
T
H
Q
I
S
D
G
LK
I
IE
K
S
P
Q
YS
G
I
G
F
Y
W
E
P
D
N
P
TFA
E
E
L
Q
HF
I
SIFRK
R
N
ATT
PL
II
F
S
EQ
N
----
IT
DR
IPL
D
V
L
K
-----
E
V
S
E
Y
V
Y
LFSE
S
A
A
F
T
A
N
R
LY
S
L
V
H
R
Y
ADK
L
LPP
Y
F
K
T
L
KD
F
T
E
D
G
D
Y
Y
W
DC
PGHMGG
M
A
Y
L
K
H
PVG
I
E
F
I
N
FFG
E
N
M
M
R
A
DI
G
VA
TA
E
M
G
DY
L
I
H
A
GP
P
K
K
S
E
E
I
A
AR
L
FG
S
D
W
TF
Y
G
V
S
G
S
S
G
SN
R
IV
A
QA
A
VG
A
DEIA
I
IDRNCHKSL
N
H
G
L
T
L
S
Q
A
R
PVY
LK
PTRNA
W
G
L
I
G
P
IP
TG
RL
K
KA
S
I
D
AL
V
A
N
S
R
L
ASGA
V
S
Q
S
P
SY
AV
V
TN
C
TYDG
F
C
YN
V
N
D
V
V
R
H
L
GE
S
A
P
R
IHFD
E
AW
Y
A
Y
A
R
F
H
P
L
Y
Q
S
R
Y
A
M
DA
E
ET
P
---
N
R
PT
L
F
A
V
QSTHK
M
L
P
S
LS
M
AS
M
IHV
KKSD
R
A
PL
N
F
D
D
FN
D
A
F
MMH
G
TTSP
Y
Y
P
I
I
AS
I
DV
A
VS
MM
E
G
E
S
G
Y
S
L
V
Q
E
SIE
E
AI
A
FRK
A
V
V
SVK
R
QL
Q
E
QEGG
D
A
WFFD
V
L
QP
TE
V
Q
D
SDS
G
QR
Y
S
F
EE
AP
VS
LL
SHS
A
D
CW
S
L
R
S
GE
R
WHGF
ADD
D
L
V
E
T
N
S
M
LDP
V
KVT
L
TC
PG
I
G
PK
G
E
YQ
K
N
GIP
GY
L
L
T
RF
LD
D
R
R
I
E
I
A
R
TG
D
Y
T
V
L
I
LFS
V
GI
T
K
G
K
W
GT
L
I
E
S
L
L
A
FK
K
H
YD
N
D
DLAT
D
A
I
P
S
L
K
A
HS
P
H-
Y
D
T
L
T
LK
E
L
C
Q
I
M
H
E
K
M
DE
LE
L
M
S
H
I
N
D
A
V
NT
D
P
E
P
V
MTP
AE
A
Y
Q
KV
V
R
Y
K
T
E
H
I
R
L
D
D
FS
GRI
A
A
S
M
LV
PYPPG
I
P
V
LMPGE
R
M
P
Q
G
N
K
G
II
G
Y
L
R
A
L
QE
F
D
K
Q
F
PGFE
HE
I
Q
G
V
NVDE
N
G
D
F
W
V
R
A
I
fig|585035.6.peg.4603
Escherichia coli S88 (25-761/789)
L
E
EL
QT
E
L
AE
R
G
F
K
I
H
I
T
H
Q
I
S
D
G
LK
I
IE
K
S
P
Q
YS
G
I
G
F
Y
W
E
P
D
N
P
TFA
E
E
L
Q
HF
I
SIFRK
R
N
ATT
PL
II
F
S
EQ
N
----
IT
DR
IPL
D
V
L
K
-----
E
V
S
E
Y
V
Y
LFSE
S
A
A
F
T
A
N
R
LY
S
L
V
H
R
Y
ADK
L
LPP
Y
F
K
T
L
KD
F
T
E
D
G
D
Y
Y
W
DC
PGHMGG
M
A
Y
L
K
H
PVG
I
E
F
I
N
FFG
E
N
M
M
R
A
DI
G
VA
TA
E
M
G
DY
L
I
H
A
GP
P
K
K
S
E
E
I
A
AR
L
FG
S
D
W
TF
Y
G
V
S
G
S
S
G
SN
R
IV
A
QA
A
VG
A
DEIA
I
IDRNCHKSL
N
H
G
L
T
L
S
Q
A
R
PVY
LK
PTRNA
W
G
L
I
G
P
IP
TG
RL
K
KA
S
I
D
AL
V
A
N
S
R
L
ASGA
V
S
Q
S
P
SY
AV
V
TN
C
TYDG
F
C
YN
V
N
D
V
V
R
H
L
GE
S
A
P
R
IHFD
E
AW
Y
A
Y
A
R
F
H
P
L
Y
Q
S
R
Y
A
M
DA
E
ET
P
---
N
R
PT
L
F
A
V
QSTHK
M
L
P
S
LS
M
AS
M
IHV
KKSD
R
A
PL
N
F
D
D
FN
D
A
F
MMH
G
TTSP
Y
Y
P
I
I
AS
I
DV
A
VS
MM
E
G
E
S
G
Y
S
L
V
Q
E
SIE
E
AI
A
FRK
A
V
V
SVK
R
QL
Q
E
QEGG
D
A
WFFD
V
L
QP
TE
V
Q
D
SDS
G
QR
Y
S
F
EE
AP
VS
LL
SHS
A
D
CW
S
L
R
S
GE
R
WHGF
ADD
D
L
V
E
T
N
S
M
LDP
V
KVT
L
TC
PG
I
G
PK
G
E
YQ
K
N
GIP
GY
L
L
T
RF
LD
D
R
R
I
E
I
A
R
TG
D
Y
T
V
L
I
LFS
V
GI
T
K
G
K
W
GT
L
I
E
S
L
L
A
FK
K
H
YD
N
D
DLAT
D
A
I
P
S
L
K
A
HS
P
H-
Y
D
T
L
T
LK
E
L
C
Q
I
M
H
E
K
M
DE
LE
L
M
S
H
I
N
D
A
V
NT
D
P
E
P
V
MTP
AE
A
Y
Q
KV
V
R
Y
K
T
E
H
I
R
L
D
D
FS
GRI
A
A
S
M
LV
PYPPG
I
P
V
LMPGE
R
M
P
Q
G
N
K
G
II
G
Y
L
R
A
L
QE
F
D
K
Q
F
PGFE
HE
I
Q
G
V
NVDE
N
G
D
F
W
V
R
A
I
fig|749527.3.peg.1826
Escherichia coli MS 21-1 (25-761/789)
L
E
EL
QT
E
L
AE
R
G
F
K
I
H
L
T
H
Q
I
S
D
G
LK
I
IE
K
S
P
Q
YSM
I
G
F
Y
W
E
P
D
N
P
TFA
E
E
L
Q
HF
I
SIFRK
R
N
AAT
PL
II
F
S
EQ
N
----
IT
DR
IPL
D
V
L
K
-----
E
V
S
E
Y
V
Y
LFSE
S
A
A
F
T
A
N
R
LY
S
L
V
H
R
Y
ADK
L
LPP
Y
F
K
T
L
KN
F
T
E
D
G
D
Y
Y
W
DC
PGHMGG
M
A
Y
L
K
H
PVG
I
E
F
I
N
FFG
E
N
M
M
R
A
DI
G
VA
TA
E
M
G
DY
L
I
H
A
GP
P
K
K
S
E
E
I
A
AR
L
FG
S
D
W
TF
Y
G
V
S
G
S
S
G
SN
R
IV
A
QA
A
VG
A
DEIA
I
IDRNCHKSL
N
H
G
L
T
L
S
Q
A
R
PVY
LK
PTRNA
W
G
L
I
G
P
IP
TG
RL
K
KA
S
I
D
AL
V
A
N
S
R
L
APGA
V
S
Q
S
P
SY
AV
V
TN
C
TYDG
F
C
YN
V
N
D
V
V
R
H
L
GE
S
A
P
R
IHFD
E
AW
Y
A
Y
A
R
F
H
P
L
Y
Q
S
R
Y
A
M
DA
E
ET
P
---
N
R
PT
L
F
A
V
QSTHK
M
L
P
S
LS
M
AS
M
IHV
KKSD
R
A
PL
N
F
D
D
FN
D
A
F
MMH
G
TTSP
Y
Y
P
I
I
AS
I
DV
A
VS
MM
E
G
E
S
G
Y
S
L
V
Q
E
SIE
E
AI
A
FRK
A
V
V
SVK
R
QL
Q
E
QEGG
D
A
WFFD
V
L
QP
TE
V
Q
D
SDS
G
QR
Y
S
F
EE
AP
VS
LL
SHS
A
D
CW
S
L
R
S
GE
R
WHGF
ADD
D
L
V
E
T
N
S
M
LDP
V
KVT
L
TC
PG
I
G
PK
G
E
YQ
K
N
GIP
GY
L
L
T
RF
LD
D
R
R
I
E
I
A
R
TG
D
Y
T
V
L
I
LFS
V
GI
T
K
G
K
W
GT
L
I
E
S
L
L
A
FK
K
H
YD
N
D
DLAT
D
A
I
P
S
L
K
A
HS
P
H-
Y
D
T
L
T
LK
E
L
C
Q
T
M
H
E
K
M
DE
LE
L
M
S
H
I
N
D
A
V
NT
D
P
E
P
V
MTP
AE
A
Y
Q
KV
V
R
Y
K
T
E
H
I
R
L
D
D
FS
GRI
A
A
S
M
LV
PYPPG
I
P
V
LMPGE
R
M
P
Q
G
N
K
G
II
G
Y
L
R
A
L
QE
F
D
K
Q
F
PGFE
HE
I
Q
G
V
NVDE
N
G
D
F
W
V
R
A
I
fig|749545.3.peg.2421
Escherichia coli MS 182-1 (22-755/756)
V
E
R
L
AD
AL
SQ
QN
VTV
I
K
S
T
S
F
DD
GFA
I
LS
S
N
E
A
I
DCLM
F
SYQ
M
E
H
P
D
EH
Q
N
V
R
QL
IGKLHERQQ
N
V
P
VFLL
G
DR
E
KA
L
AAM
DR
---
DL
L
E
-----
L
V
D
E
F
AWI
L
ED
T
A
DF
IA
G
R
AV
A
A
M
T
R
Y
RQQ
L
LPPL
FS
AL
M
KY
S
D
I
H
E
Y
SWAA
PGH
Q
GG
VG
F
T
K
T
P
A
G
R
FYH
D
YY
G
E
N
L
F
R
T
D
M
G
I
ER
T
S
LGSLLDHTG
AF
G
E
S
E
K
Y
A
ARVFGADRS
W
S
V
VV
GTS
G
SN
RTIMQA
C
MT
D
NDV
V
VV
DRNCHKS
I
E
QG
LM
L
T
GA
K
PVY
MV
P
S
RN
R
YGI
I
G
P
I
Y
PQ
E
M
Q
PE
T
L
Q
KK
I
S
E
S
P
LTKDK
A
G
Q
K
P
SYC
V
V
TN
C
TYDG
VC
YN
AK
E
AQ
D
L
L
EK
T
S
DRL
HFD
E
AW
YG
Y
A
R
F
N
PIY
A
DH
Y
A
MSGE
--
PGDH
N
G
PTV
F
A
T
H
STHKLL
N
ALSQAS
Y
IHV
REG
-
R
G
AI
N
FS
R
FN
Q
AYMMH
A
TTSP
L
Y
A
I
C
AS
N
DV
A
VS
MM
D
GN
S
G
LS
L
TQ
E
V
I
DE
A
V
D
FR
QA
M
A
---
RL
Y
K
E
FTADGS
WFF
K
P
W
NK
EV
V
T
D
PQTGKTYDFADAPTKLLTTV
Q
D
CW
V
M
H
PGE
S
WHGF
--
KDI
P
D
N
WS
M
LDPIKV
S
IL
A
PGM
G
EDG
E
LE
E
T
G
V
PAALV
TA
W
L
GR
HGIV
PTR
T
TDFQIM
FLFS
M
G
VTRG
K
W
GT
L
VN
T
L
C
S
FKR
H
YD
A
N
TP
L
AQVM
P
E
L
V
E
QY
PD
T
Y
A
NM
G
I
H
DL
GD
T
MFAWL
KE
N
N
PG
A
RL
N
E
A
Y
SG
LP
M
A
E
I
TP
RE
A
Y
N
AI
V
D
N
N
VE
L
V
S
I
E
N
L
P
GRI
A
AN
SVI
PYPPG
I
P
M
L
LS
GE
N
F
G
D
KNS
P
QV
S
Y
L
R
S
L
Q
S
W
D
H
H
F
PGFE
HETE
G
T
EI-I
DG
I
Y
H
V
M
CV
K
fig|216592.1.peg.2418
Escherichia coli 042 (22-755/756)
V
E
R
L
AD
AL
SQ
QN
VTV
I
K
S
T
S
F
DD
GFA
I
LS
S
N
E
A
I
DCLM
F
SYQ
M
E
H
P
D
EH
Q
N
V
R
QL
IGKLHERQQ
N
V
P
VFLL
G
DR
E
KA
L
AAM
DR
---
DL
L
E
-----
L
V
D
E
F
AWI
L
ED
T
A
DF
IA
G
R
AV
A
A
M
T
R
Y
RQQ
L
LPPL
FS
AL
M
KY
S
D
I
H
E
Y
SWAA
PGH
Q
GG
VG
F
T
K
T
P
A
G
R
FYH
DF
Y
G
E
N
L
F
R
T
D
M
G
I
ER
T
S
LGSLLDHTG
AF
G
E
S
E
K
Y
A
ARVFGADRS
W
S
V
VV
GTS
G
SN
RTIMQA
C
MT
D
NDV
V
VV
DRNCHKS
I
E
QG
LM
L
T
GA
K
PVY
MV
P
S
RN
R
YGI
I
G
P
I
Y
PQ
E
M
Q
PE
T
L
Q
KK
I
S
E
S
P
LTKDK
A
G
Q
K
P
SYC
V
V
TN
C
TYDG
VC
YN
AK
E
AQ
D
L
L
EK
T
S
DRL
HFD
E
AW
YG
Y
A
R
F
N
PIY
A
DH
Y
A
M
R
GE
--
PGDH
N
G
PTV
F
A
T
H
STHKLL
N
ALSQAS
Y
IHV
REG
-
R
G
AI
N
FS
R
FN
Q
AYMMH
A
TTSP
L
Y
A
I
C
AS
N
DV
A
VS
MM
D
GN
S
G
LS
L
TQ
E
V
I
DE
A
V
D
FR
QA
M
A
---
RL
Y
K
E
FTADGS
WFF
K
P
W
NK
EV
V
T
D
PQTGKTYDFADAPTKLLTTV
Q
D
CW
V
M
H
PGE
S
WHGF
--
KDI
P
D
N
WS
M
LDPIKV
S
IL
A
PGM
G
EDG
E
LE
E
T
G
V
PAALV
TA
W
L
GR
HGIV
PTR
T
TDFQIM
FLFS
M
GI
TRG
K
W
GT
L
VN
T
L
C
S
FKR
H
YD
A
N
TP
L
AQVM
P
E
L
V
E
QY
PD
T
Y
A
NM
G
I
H
DL
GD
T
MFAWL
KE
N
N
PG
A
RL
N
E
A
Y
SG
LP
V
A
E
I
TP
RE
A
Y
N
AI
V
D
N
N
VE
L
V
S
I
E
N
L
P
GRI
A
AN
SVI
PYPPG
I
P
M
L
LS
GE
N
F
G
D
KNS
P
QV
S
Y
L
R
S
L
Q
S
W
D
H
H
F
PGFE
HETE
G
T
EI-I
DG
I
Y
H
V
M
CV
K
fig|216592.3.peg.4654
Escherichia coli 042 (22-755/756)
V
E
R
L
AD
AL
SQ
QN
VTV
I
K
S
T
S
F
DD
GFA
I
LS
S
N
E
A
I
DCLM
F
SYQ
M
E
H
P
D
EH
Q
N
V
R
QL
IGKLHERQQ
N
V
P
VFLL
G
DR
E
KA
L
AAM
DR
---
DL
L
E
-----
L
V
D
E
F
AWI
L
ED
T
A
DF
IA
G
R
AV
A
A
M
T
R
Y
RQQ
L
LPPL
FS
AL
M
KY
S
D
I
H
E
Y
SWAA
PGH
Q
GG
VG
F
T
K
T
P
A
G
R
FYH
DF
Y
G
E
N
L
F
R
T
D
M
G
I
ER
T
S
LGSLLDHTG
AF
G
E
S
E
K
Y
A
ARVFGADRS
W
S
V
VV
GTS
G
SN
RTIMQA
C
MT
D
NDV
V
VV
DRNCHKS
I
E
QG
LM
L
T
GA
K
PVY
MV
P
S
RN
R
YGI
I
G
P
I
Y
PQ
E
M
Q
PE
T
L
Q
KK
I
S
E
S
P
LTKDK
A
G
Q
K
P
SYC
V
V
TN
C
TYDG
VC
YN
AK
E
AQ
D
L
L
EK
T
S
DRL
HFD
E
AW
YG
Y
A
R
F
N
PIY
A
DH
Y
A
M
R
GE
--
PGDH
N
G
PTV
F
A
T
H
STHKLL
N
ALSQAS
Y
IHV
REG
-
R
G
AI
N
FS
R
FN
Q
AYMMH
A
TTSP
L
Y
A
I
C
AS
N
DV
A
VS
MM
D
GN
S
G
LS
L
TQ
E
V
I
DE
A
V
D
FR
QA
M
A
---
RL
Y
K
E
FTADGS
WFF
K
P
W
NK
EV
V
T
D
PQTGKTYDFADAPTKLLTTV
Q
D
CW
V
M
H
PGE
S
WHGF
--
KDI
P
D
N
WS
M
LDPIKV
S
IL
A
PGM
G
EDG
E
LE
E
T
G
V
PAALV
TA
W
L
GR
HGIV
PTR
T
TDFQIM
FLFS
M
GI
TRG
K
W
GT
L
VN
T
L
C
S
FKR
H
YD
A
N
TP
L
AQVM
P
E
L
V
E
QY
PD
T
Y
A
NM
G
I
H
DL
GD
T
MFAWL
KE
N
N
PG
A
RL
N
E
A
Y
SG
LP
V
A
E
I
TP
RE
A
Y
N
AI
V
D
N
N
VE
L
V
S
I
E
N
L
P
GRI
A
AN
SVI
PYPPG
I
P
M
L
LS
GE
N
F
G
D
KNS
P
QV
S
Y
L
R
S
L
Q
S
W
D
H
H
F
PGFE
HETE
G
T
EI-I
DG
I
Y
H
V
M
CV
K
fig|656414.3.peg.4677
Escherichia coli H736 (22-755/756)
V
E
R
L
AD
AL
SQ
QN
VTV
I
K
S
T
S
F
DD
GFA
I
LS
S
N
E
A
I
DCLM
F
SYQ
M
E
H
P
D
EH
Q
N
V
R
QL
IGKLHERQQ
N
V
P
VFLL
G
DR
E
KA
L
AAM
DR
---
DL
L
E
-----
L
V
D
E
F
AWI
L
ED
T
A
DF
IA
G
R
AV
A
A
M
T
R
Y
RQQ
L
LPPL
FS
AL
M
KY
S
D
I
H
E
Y
SWAA
PGH
Q
GG
VG
F
T
K
T
P
A
G
R
FYH
D
YY
G
E
N
L
F
R
T
D
M
G
I
ER
T
S
LGSLLDHTG
AF
G
E
S
E
K
Y
A
ARVFGADRS
W
S
V
VV
GTS
G
SN
RTIMQA
C
MT
D
NDV
V
VV
DRNCHKS
I
E
QG
LM
L
T
GA
K
PVY
MV
P
S
RN
R
YGI
I
G
P
I
Y
PQ
E
M
Q
PE
T
L
Q
KK
I
S
E
S
P
LTKDK
A
G
Q
K
P
SYC
V
V
TN
C
TYDG
VC
YN
AK
E
AQ
D
L
L
EK
T
S
DRL
HFD
E
AW
YG
Y
A
R
F
N
PIY
A
DH
Y
A
M
R
GE
--
PGDH
N
G
PTV
F
A
T
H
STHKLL
N
ALSQAS
Y
IHV
REG
-
R
G
AI
N
FS
R
FN
Q
AYMMHTTTSP
L
Y
A
I
C
AS
N
DV
A
VS
MM
D
GN
S
G
LS
L
TQ
E
V
I
DE
A
V
D
FR
QA
M
A
---
RL
Y
K
E
FTADGS
WFF
K
P
W
NK
EV
V
T
D
PQTGKTYDFADAPTKLLTTV
Q
D
CW
V
M
H
PGE
S
WHGF
--
KDI
P
D
N
WS
M
LDPIKV
S
IL
A
PGM
G
EDG
E
LE
E
T
G
V
PAALV
TA
W
L
GR
HGIV
PTR
T
TDFQIM
FLFS
M
G
VTRG
K
W
GT
L
VN
T
L
C
S
FKR
H
YD
A
N
TP
L
AQVM
P
E
L
V
E
QY
PD
T
Y
A
NM
G
I
H
DL
GD
T
MFAWL
KE
N
N
PG
A
RL
N
E
A
Y
SG
LP
V
A
E
V
TP
RE
A
Y
N
AI
V
D
N
N
VE
L
V
S
I
E
N
L
P
GRI
A
AN
SVI
PYPPG
I
P
M
L
LS
GE
N
F
G
D
KNS
P
QV
S
Y
L
R
S
L
Q
S
W
D
H
H
F
PGFE
HETE
G
T
EI-I
DG
I
Y
H
V
M
CV
K
fig|656393.3.peg.233
Escherichia coli H299 (22-755/756)
V
E
R
L
AD
AL
SQ
QN
VTV
I
K
S
T
S
F
DD
GFA
I
LS
S
N
E
A
I
DCLM
F
SYQ
M
E
H
P
D
EH
Q
N
V
R
QL
IGKLHERQQ
N
V
P
VFLL
G
DR
E
KA
L
AAM
DR
---
DL
L
E
-----
L
V
D
E
F
AWI
L
ED
T
A
DF
IA
G
R
AV
A
A
M
T
R
Y
RQQ
L
LPPL
FS
AL
M
KY
S
D
I
H
E
Y
SWAA
PGH
Q
GG
VG
F
T
K
T
P
A
G
R
FYH
D
YY
G
E
N
L
F
R
T
D
M
G
I
ER
T
S
LGSLLDHTG
AF
G
E
S
E
R
Y
A
ARVFGADRS
W
S
V
VV
GTS
G
SN
RTIMQA
C
MT
D
NDV
V
VV
DRNCHKS
I
E
QG
LM
L
T
GA
K
PVY
MV
P
S
RN
R
YGI
I
G
P
I
Y
PQ
E
M
Q
PE
T
L
Q
KK
I
S
E
S
P
LTKDK
A
G
Q
K
P
SYC
V
V
TN
C
TYDG
VC
YN
AK
E
V
Q
D
L
L
EK
T
S
DRL
HFD
E
AW
YG
Y
A
R
F
N
PIY
A
DH
Y
A
M
R
GE
--
PGDH
N
G
PTV
F
A
T
H
STHKLL
N
ALSQAS
Y
IHV
REG
-
R
G
AI
N
FS
R
FN
Q
AYMMH
A
TTSP
L
Y
A
I
C
AS
N
DV
A
VS
MM
D
GN
S
G
LS
L
TQ
E
V
I
DE
A
V
D
FR
QA
M
A
---
RL
Y
K
E
FTADGS
WFF
K
P
W
NK
EV
V
T
D
PQTGKTYDFADAPTKLLTTV
Q
D
CW
V
M
H
PGE
S
WHGF
--
KDI
P
D
N
WS
M
LDPIKV
S
IL
A
PGM
G
EDG
E
LE
E
T
G
V
PAALV
TA
W
L
GR
HGIV
PTR
T
TDFQIM
FLFS
M
G
VTRG
K
W
GT
L
VN
T
L
C
S
FKR
H
YD
A
N
TP
L
AQVM
P
E
L
V
E
QY
PD
T
Y
A
NM
G
I
H
DL
GD
T
MFAWL
KE
N
N
PG
A
RL
N
E
A
Y
SG
LP
V
A
E
I
TP
RE
A
Y
N
AI
V
D
N
N
VE
L
V
S
I
E
N
L
P
GRI
A
AN
SVI
PYPPG
I
P
M
L
LS
GE
N
F
G
D
KNS
P
QV
S
Y
L
R
S
L
Q
S
W
D
H
H
F
PGFE
HETE
G
T
EI-I
DG
I
Y
H
V
M
CV
K
fig|481805.3.peg.4200
Escherichia coli ATCC 8739 (22-755/756)
V
E
R
L
AD
AL
SQ
QN
VTV
I
K
S
T
S
F
DD
GFA
I
LS
S
N
E
A
I
DCLM
F
SYQ
M
E
H
P
D
EH
Q
N
V
R
QL
IGKLHERQQ
N
V
P
VFLL
G
DR
E
KA
L
AAM
DR
---
DL
L
E
-----
L
V
D
E
F
AWI
L
ED
T
A
DF
IA
G
R
AV
A
A
M
T
R
Y
RQQ
L
LPPL
FS
AL
M
KY
S
D
I
H
E
Y
SWAA
PGH
Q
GG
VG
F
T
K
T
P
A
G
R
FYH
D
YY
G
E
N
L
F
R
T
D
M
G
I
ER
T
S
LGSLLDHTG
AF
G
E
S
E
K
Y
A
ARVFGADRS
W
S
V
VV
GTS
G
SN
RTIMQA
C
MT
D
NDV
V
VV
DRNCHKS
I
E
QG
LM
L
T
GA
K
PVY
MV
P
S
RN
R
YGI
I
G
P
I
Y
PQ
E
M
Q
PE
SL
Q
KK
I
S
E
S
P
LTKDK
A
G
Q
K
P
SYC
V
V
TN
C
TYDG
VC
YN
AK
E
AQ
D
L
L
EK
T
S
DRL
HFD
E
AW
YG
Y
A
R
F
N
PIY
A
DH
Y
A
M
R
GE
--
PGDH
N
G
PTV
F
A
T
H
STHKLL
N
ALSQAS
Y
IHV
REG
-
R
G
AI
N
FS
R
FN
Q
AYMMH
A
TTSP
L
Y
A
I
C
AS
N
DV
A
VS
MM
D
GN
S
G
LS
L
TQ
E
V
I
DE
A
V
D
FR
QA
M
A
---
RL
Y
K
E
FTADGS
WFF
K
P
W
NK
EV
V
T
D
PQTGKTYDFADAPTKLLTTV
Q
D
CW
V
M
H
PGE
S
WHGF
--
KDI
P
D
N
WS
M
LDPIKV
S
IL
A
PGM
G
EDG
E
LE
E
T
G
V
PAALV
TA
W
L
GR
HGIV
PTR
T
TDFQIM
FLFS
M
G
VTRG
K
W
GT
L
VN
T
L
C
S
FKR
H
YD
A
N
TP
L
AQVM
P
E
L
V
E
QY
PD
T
Y
A
NM
G
I
H
DL
GD
T
MFAWL
KE
N
N
PG
A
RL
N
E
A
Y
SG
LP
V
A
E
I
TP
RE
A
Y
N
AI
V
D
N
N
VE
L
V
S
I
E
N
L
P
GRI
A
AN
SVI
PYPPG
I
P
M
L
LS
GE
N
F
G
D
KNS
P
QV
S
Y
L
R
S
L
Q
S
W
D
H
H
F
PGFE
HETE
G
T
EI-I
DG
I
Y
H
V
M
CV
K
fig|481805.6.peg.4186
Escherichia coli ATCC 8739 (22-755/756)
V
E
R
L
AD
AL
SQ
QN
VTV
I
K
S
T
S
F
DD
GFA
I
LS
S
N
E
A
I
DCLM
F
SYQ
M
E
H
P
D
EH
Q
N
V
R
QL
IGKLHERQQ
N
V
P
VFLL
G
DR
E
KA
L
AAM
DR
---
DL
L
E
-----
L
V
D
E
F
AWI
L
ED
T
A
DF
IA
G
R
AV
A
A
M
T
R
Y
RQQ
L
LPPL
FS
AL
M
KY
S
D
I
H
E
Y
SWAA
PGH
Q
GG
VG
F
T
K
T
P
A
G
R
FYH
D
YY
G
E
N
L
F
R
T
D
M
G
I
ER
T
S
LGSLLDHTG
AF
G
E
S
E
K
Y
A
ARVFGADRS
W
S
V
VV
GTS
G
SN
RTIMQA
C
MT
D
NDV
V
VV
DRNCHKS
I
E
QG
LM
L
T
GA
K
PVY
MV
P
S
RN
R
YGI
I
G
P
I
Y
PQ
E
M
Q
PE
SL
Q
KK
I
S
E
S
P
LTKDK
A
G
Q
K
P
SYC
V
V
TN
C
TYDG
VC
YN
AK
E
AQ
D
L
L
EK
T
S
DRL
HFD
E
AW
YG
Y
A
R
F
N
PIY
A
DH
Y
A
M
R
GE
--
PGDH
N
G
PTV
F
A
T
H
STHKLL
N
ALSQAS
Y
IHV
REG
-
R
G
AI
N
FS
R
FN
Q
AYMMH
A
TTSP
L
Y
A
I
C
AS
N
DV
A
VS
MM
D
GN
S
G
LS
L
TQ
E
V
I
DE
A
V
D
FR
QA
M
A
---
RL
Y
K
E
FTADGS
WFF
K
P
W
NK
EV
V
T
D
PQTGKTYDFADAPTKLLTTV
Q
D
CW
V
M
H
PGE
S
WHGF
--
KDI
P
D
N
WS
M
LDPIKV
S
IL
A
PGM
G
EDG
E
LE
E
T
G
V
PAALV
TA
W
L
GR
HGIV
PTR
T
TDFQIM
FLFS
M
G
VTRG
K
W
GT
L
VN
T
L
C
S
FKR
H
YD
A
N
TP
L
AQVM
P
E
L
V
E
QY
PD
T
Y
A
NM
G
I
H
DL
GD
T
MFAWL
KE
N
N
PG
A
RL
N
E
A
Y
SG
LP
V
A
E
I
TP
RE
A
Y
N
AI
V
D
N
N
VE
L
V
S
I
E
N
L
P
GRI
A
AN
SVI
PYPPG
I
P
M
L
LS
GE
N
F
G
D
KNS
P
QV
S
Y
L
R
S
L
Q
S
W
D
H
H
F
PGFE
HETE
G
T
EI-I
DG
I
Y
H
V
M
CV
K
fig|344601.3.peg.1149
Escherichia coli B171 (22-755/756)
V
E
R
L
AD
AL
SQ
QN
VTV
I
K
S
T
S
F
DD
GFA
I
LS
S
N
E
A
I
DCLM
F
SYQ
M
E
H
P
D
EH
Q
N
V
R
QL
IGKLHERQQ
N
V
P
VFLL
G
DR
E
KA
L
AAM
DR
---
DL
L
E
-----
L
V
D
E
F
AWI
L
ED
T
A
DF
IA
G
R
AV
A
A
M
T
R
Y
RQQ
L
LPPL
F
R
AL
M
KY
S
D
I
H
E
Y
SWAA
PGH
Q
GG
VG
F
T
K
T
P
A
G
R
FYH
D
YY
G
E
N
L
F
R
T
D
M
G
I
ER
T
S
LGSLLDHTG
AF
G
E
S
E
K
Y
A
ARVFGADRS
W
S
V
VV
GTS
G
SN
RTIMQA
C
MT
D
NDV
V
VV
DRNCHKS
I
E
QG
LM
L
T
GA
K
PVY
MV
P
S
RN
R
YGI
I
G
P
I
Y
PQ
E
M
Q
PE
T
L
Q
KK
I
S
E
S
P
LTKDK
A
G
Q
K
P
SYC
V
V
TN
C
TYDG
VC
YN
AK
E
AQ
D
L
L
EK
T
S
DRL
HFD
E
AW
YG
Y
A
R
F
N
PIY
A
DH
Y
A
M
R
GE
--
PGDH
N
G
PTV
F
A
T
H
STHKLL
N
ALSQAS
Y
IHV
REG
-
R
G
AI
N
FS
R
FN
Q
AYMMH
A
TTSP
L
Y
A
I
C
AS
N
DV
A
VS
MM
D
GN
S
G
LS
L
TQ
E
V
I
DE
A
V
D
FR
QA
M
A
---
RL
Y
K
E
FTADGS
WFF
K
P
W
NK
EV
V
T
D
PQTGKTYDFADAPTKLLTTV
Q
D
CW
V
M
H
PGE
S
WHGF
--
KDI
P
D
N
WS
M
LDPIKV
S
IL
A
PGM
G
EDG
E
LE
E
T
G
V
PAALV
TA
W
L
GR
HGIV
PTR
T
TDFQIM
FLFS
M
G
VTRG
K
W
GT
L
VN
T
L
C
S
FKR
H
YD
A
N
TP
L
AQVM
P
E
L
V
E
QY
PD
T
Y
A
NM
G
I
H
DL
GD
T
MFAWL
KE
N
N
PG
A
RL
N
E
A
Y
SG
LP
V
A
E
V
TP
RE
A
Y
N
AI
V
D
N
N
VE
L
V
S
I
E
N
L
P
GRI
A
AN
SVI
PYPPG
I
P
M
L
LS
GE
N
F
G
D
KNS
P
QV
S
Y
L
R
S
L
Q
S
W
D
H
H
F
PGFE
HETE
G
T
EI-I
DG
I
Y
H
V
M
CV
K
fig|344601.5.peg.1214
Escherichia coli B171 (22-755/756)
V
E
R
L
AD
AL
SQ
QN
VTV
I
K
S
T
S
F
DD
GFA
I
LS
S
N
E
A
I
DCLM
F
SYQ
M
E
H
P
D
EH
Q
N
V
R
QL
IGKLHERQQ
N
V
P
VFLL
G
DR
E
KA
L
AAM
DR
---
DL
L
E
-----
L
V
D
E
F
AWI
L
ED
T
A
DF
IA
G
R
AV
A
A
M
T
R
Y
RQQ
L
LPPL
F
R
AL
M
KY
S
D
I
H
E
Y
SWAA
PGH
Q
GG
VG
F
T
K
T
P
A
G
R
FYH
D
YY
G
E
N
L
F
R
T
D
M
G
I
ER
T
S
LGSLLDHTG
AF
G
E
S
E
K
Y
A
ARVFGADRS
W
S
V
VV
GTS
G
SN
RTIMQA
C
MT
D
NDV
V
VV
DRNCHKS
I
E
QG
LM
L
T
GA
K
PVY
MV
P
S
RN
R
YGI
I
G
P
I
Y
PQ
E
M
Q
PE
T
L
Q
KK
I
S
E
S
P
LTKDK
A
G
Q
K
P
SYC
V
V
TN
C
TYDG
VC
YN
AK
E
AQ
D
L
L
EK
T
S
DRL
HFD
E
AW
YG
Y
A
R
F
N
PIY
A
DH
Y
A
M
R
GE
--
PGDH
N
G
PTV
F
A
T
H
STHKLL
N
ALSQAS
Y
IHV
REG
-
R
G
AI
N
FS
R
FN
Q
AYMMH
A
TTSP
L
Y
A
I
C
AS
N
DV
A
VS
MM
D
GN
S
G
LS
L
TQ
E
V
I
DE
A
V
D
FR
QA
M
A
---
RL
Y
K
E
FTADGS
WFF
K
P
W
NK
EV
V
T
D
PQTGKTYDFADAPTKLLTTV
Q
D
CW
V
M
H
PGE
S
WHGF
--
KDI
P
D
N
WS
M
LDPIKV
S
IL
A
PGM
G
EDG
E
LE
E
T
G
V
PAALV
TA
W
L
GR
HGIV
PTR
T
TDFQIM
FLFS
M
G
VTRG
K
W
GT
L
VN
T
L
C
S
FKR
H
YD
A
N
TP
L
AQVM
P
E
L
V
E
QY
PD
T
Y
A
NM
G
I
H
DL
GD
T
MFAWL
KE
N
N
PG
A
RL
N
E
A
Y
SG
LP
V
A
E
V
TP
RE
A
Y
N
AI
V
D
N
N
VE
L
V
S
I
E
N
L
P
GRI
A
AN
SVI
PYPPG
I
P
M
L
LS
GE
N
F
G
D
KNS
P
QV
S
Y
L
R
S
L
Q
S
W
D
H
H
F
PGFE
HETE
G
T
EI-I
DG
I
Y
H
V
M
CV
K
fig|749527.3.peg.5036
Escherichia coli MS 21-1 (22-755/756)
V
E
R
L
AD
AL
SQ
QN
VTV
I
K
S
T
S
F
DD
GFA
I
LS
S
N
E
A
I
DCLM
F
SYQ
M
E
H
P
D
EH
Q
N
V
R
QL
IGKLHERQQ
N
V
P
VFLL
G
DR
E
KA
L
AAM
DR
---
DL
L
E
-----
L
V
D
E
F
AWI
L
ED
T
A
DF
IA
G
R
AV
A
A
M
T
R
Y
RQQ
L
LPPL
FS
AL
M
KY
S
D
I
H
E
Y
SWAA
PGH
Q
GG
VG
F
T
K
T
P
A
G
R
FYH
D
YY
G
E
N
L
F
R
T
D
M
G
I
ER
T
S
LGSLLDHTG
AF
G
E
S
E
K
Y
A
ARVFGADRS
W
S
V
VV
GTS
G
SN
RTIMQA
C
MT
D
NDV
V
VV
DRNCHKS
I
E
QG
LM
L
T
GA
K
PVY
MV
P
S
RN
R
YGI
I
G
P
I
Y
PQ
E
M
Q
PE
T
L
Q
KK
I
S
E
S
P
LTKDK
A
G
Q
K
P
SYC
V
V
TN
C
TYDG
VC
YN
AK
E
AQ
D
L
L
EK
T
S
DRL
HFD
E
AW
YG
Y
A
R
F
N
PIY
A
DH
Y
A
M
R
GE
--
PGDH
N
G
PTV
F
A
T
H
STHKLL
N
ALSQAS
Y
IHV
REG
-
R
G
AI
N
FS
R
FN
Q
AYMMH
A
TTSP
L
Y
A
I
C
AS
N
DV
A
VS
MM
D
GN
S
G
LS
L
TQ
E
V
I
DE
A
V
D
FR
QA
M
A
---
RL
Y
K
E
FTADGS
WFF
K
P
W
NK
EV
V
T
D
PQTGKTYDFADAPTKLLTTV
Q
D
CW
V
M
H
PGE
S
WHGF
--
KDI
P
D
N
WS
M
LDPIKV
S
IL
A
PGM
G
EDG
E
LE
E
T
G
V
PAALV
TA
W
L
GR
HGIV
PTR
T
TDFQIM
FLFS
M
G
VTRG
K
W
GT
L
VN
T
L
C
S
FKR
H
YD
A
N
TP
L
AQVM
P
E
L
V
E
QY
PD
T
Y
A
NM
G
I
H
DL
GD
T
MFAWL
KE
N
N
PG
A
RL
N
E
A
Y
SG
LP
V
A
E
I
TP
RE
A
Y
N
AI
V
D
N
N
VE
L
I
S
I
E
N
L
P
GRI
A
AN
SVI
PYPPG
I
P
M
L
LS
GE
N
F
G
D
KNS
P
QV
S
Y
L
R
S
L
Q
S
W
D
H
H
F
PGFE
HETE
G
T
EI-I
DG
I
Y
H
V
M
CV
K
fig|749531.3.peg.2380
Escherichia coli MS 69-1 (22-755/756)
V
E
R
L
AD
AL
SQ
QN
VTV
I
K
S
T
S
F
DD
GFA
I
LS
S
N
E
A
I
DCLM
F
SYQ
M
E
H
P
D
EH
Q
N
V
R
QL
IGKLHERQQ
N
V
P
VFLL
G
DR
E
KA
L
AAM
DR
---
DL
L
E
-----
L
V
D
E
F
AWI
L
ED
T
A
DF
IA
G
R
AV
A
A
M
T
R
Y
RQQ
L
LPPL
FS
AL
M
KY
S
D
I
H
E
Y
SWAA
PGH
Q
GG
VG
F
T
K
T
P
A
G
R
FYH
D
YY
G
E
N
L
F
R
T
D
M
G
I
ER
T
S
LGSLLDHTG
AF
G
E
S
E
K
Y
A
ARVFGADRS
W
S
V
VV
GTS
G
SN
RTIMQA
C
MT
D
NDV
V
VV
DRNCHKS
I
E
QG
LM
L
T
GA
K
PVY
MV
P
S
RN
R
YGI
I
G
P
I
Y
PQ
E
M
Q
PE
T
L
Q
KK
I
S
E
S
P
LTKDK
A
G
Q
K
P
SYC
V
V
TN
C
TYDG
VC
YN
AK
E
AQ
D
L
L
EK
T
S
DRL
HFD
E
AW
YG
Y
A
R
F
N
PIY
A
DH
Y
A
M
R
GE
--
PGDH
N
G
PTV
F
A
T
H
STHKLL
N
ALSQAS
Y
IHV
REG
-
R
G
AI
N
FS
R
FN
Q
AYMMH
A
TTSP
L
Y
A
I
C
AS
N
DV
A
VS
MM
D
GN
S
G
LS
L
TQ
E
V
I
DE
A
V
D
FR
QA
M
A
---
RL
Y
K
E
FTADGS
WFF
K
P
W
NK
EV
V
T
D
PQTGKTYDFADAPTKLLTTV
Q
D
CW
V
M
H
PGE
S
WHGF
--
KDI
P
D
N
WS
M
LDPIKV
S
IL
A
PGM
G
EDG
E
LE
E
T
G
V
PAALV
TA
W
L
GR
HGIV
PTR
T
TDFQIM
FLFS
M
GI
TRG
K
W
GT
L
VN
T
L
C
S
FKR
H
YD
A
N
TP
L
AQVM
P
E
L
V
E
QY
PD
T
Y
A
NM
G
I
H
DL
GD
T
MFAWL
KE
N
N
PG
A
RL
N
E
A
Y
SG
LP
V
A
E
I
TP
RE
A
Y
N
AI
V
D
N
N
VE
L
V
S
I
E
N
L
P
GRI
A
AN
SVI
PYPPG
I
P
M
L
LS
GE
N
F
G
D
KNS
P
QV
S
Y
L
R
S
L
Q
S
W
D
H
H
F
PGFE
HETE
G
T
EI-I
DG
I
Y
H
V
M
CV
K
fig|656437.3.peg.4627
Escherichia coli TA143 (22-755/756)
V
E
R
L
AD
AL
SQ
QN
VTV
I
K
S
T
S
F
DD
GFA
I
LS
S
N
E
A
I
DCLM
F
SYQ
M
E
H
P
D
EH
Q
N
V
R
QL
IGKLHERQQ
N
V
P
VFLL
G
DR
E
KA
L
AAM
DR
---
DL
L
E
-----
L
V
D
E
F
AWI
L
ED
T
A
DF
IA
G
R
AV
A
A
M
T
R
Y
RQQ
L
LPPL
FS
AL
M
KY
S
D
I
H
E
Y
SWAA
PGH
Q
GG
VG
F
T
K
T
P
A
G
R
FYH
D
YY
G
E
N
L
F
R
T
D
M
G
I
ER
T
S
LGSLLDHTG
AF
G
E
S
E
K
Y
A
ARVFGADRS
W
S
V
VV
GTS
G
SN
RTIMQA
C
MT
D
NDV
V
VV
DRNCHKS
I
E
QG
LM
L
T
GA
K
PVY
MV
P
S
RN
R
YGI
I
G
P
I
Y
PQ
E
M
Q
PE
T
L
Q
KK
I
S
E
S
P
LTKDK
A
G
Q
K
P
SYC
V
V
TN
C
TYDG
VC
YN
AK
E
AQ
D
L
L
EK
T
S
DRL
HFD
E
AW
YG
Y
A
R
F
N
PIY
A
DH
Y
A
M
R
GE
--
PGDH
N
G
PTV
F
A
T
H
STHKLL
N
ALSQAS
Y
IHV
REG
-
R
G
AI
N
FS
R
FN
Q
AYMMH
A
TTSP
L
Y
A
I
C
AS
N
DV
A
VS
MM
D
GN
S
G
LS
L
TQ
E
V
I
DE
A
V
D
FR
QA
M
A
---
RL
Y
K
E
FTADGS
WFF
K
P
W
NK
EV
V
T
D
PQTGKTYDFADAPTKLLTTV
Q
D
CW
V
M
H
PGE
S
WHGF
--
KDI
P
D
N
WS
M
LDPIKV
S
IL
A
PGM
G
EDG
E
LE
E
T
G
V
PAALV
TA
W
L
GR
HGIV
PTR
T
TDFQIM
FLFS
M
GI
TRG
K
W
GT
L
VN
T
L
C
S
FKR
H
YD
A
N
TP
L
AQVM
P
E
L
V
E
QY
PD
T
Y
A
NM
G
I
H
DL
GD
T
MFAWL
KE
N
N
PG
A
RL
N
E
A
Y
SG
LP
V
A
E
I
TP
RE
A
Y
N
AI
V
D
N
N
VE
L
V
S
I
E
N
L
P
GRI
A
AN
SVI
PYPPG
I
P
M
L
LS
GE
N
F
G
D
KNS
P
QV
S
Y
L
R
S
L
Q
S
W
D
H
H
F
PGFE
HETE
G
T
EI-I
DG
I
Y
H
V
M
CV
K
fig|656417.3.peg.5203
Escherichia coli M605 (22-755/756)
V
E
R
L
AD
AL
SQ
QN
I
TV
I
K
S
T
S
F
DD
GFA
I
LS
S
N
E
A
I
DCLM
F
SYQ
M
E
H
P
D
EH
Q
N
V
R
QL
IGKLHERQQ
N
V
P
VFLL
G
DR
E
KA
L
AAM
DR
---
DL
L
E
-----
L
V
D
E
F
AWI
L
ED
T
A
DF
IA
G
R
AV
A
A
M
T
R
Y
RQQ
L
LPPL
FS
AL
M
KY
S
D
I
H
E
Y
SWAA
PGH
Q
GG
VG
F
T
K
T
P
A
G
R
FYH
D
YY
G
E
N
L
F
R
T
D
M
G
I
ER
T
S
LGSLLDHTG
AF
G
E
S
E
K
Y
A
ARVFGADRS
W
S
V
VV
GTS
G
SN
RTIMQA
C
MT
D
NDV
V
VV
DRNCHKS
I
E
QG
LM
L
T
GA
K
PVY
MV
P
S
RN
R
YGI
I
G
P
I
Y
PQ
E
M
Q
PE
T
L
Q
KK
I
S
E
S
P
LTKDK
A
G
Q
K
P
SYC
V
V
TN
C
TYDG
VC
YN
AK
E
AQ
D
L
L
EK
T
S
DRL
HFD
E
AW
YG
Y
A
R
F
N
PIY
A
DH
Y
A
M
R
GE
--
PGDH
N
G
PTV
F
A
T
H
STHKLL
N
ALSQAS
Y
IHV
REG
-
R
G
AI
N
FS
R
FN
Q
AYMMH
A
TTSP
L
Y
A
I
C
AS
N
DV
A
VS
MM
D
GN
S
G
LS
L
TQ
E
V
I
DE
A
V
D
FR
QA
M
A
---
RL
Y
K
E
FTADGS
WFF
K
P
W
NK
EV
V
T
D
PQTGKTYDFADAPTKLLTTV
Q
D
CW
V
M
H
PGE
S
WHGF
--
KDI
P
D
N
WS
M
LDPIKV
S
IL
A
PGM
G
EDG
E
LE
E
T
G
V
PAALV
TA
W
L
GR
HGIV
PTR
T
TDFQIM
FLFS
M
G
VTRG
K
W
GT
L
VN
T
L
C
S
FKR
H
YD
A
N
TP
L
AQVM
P
E
L
V
E
QY
PD
T
Y
A
NM
G
I
H
DL
GD
T
MFAWL
KE
N
N
PG
A
RL
N
E
A
Y
SG
LP
V
A
E
I
TP
RE
A
Y
N
AI
V
D
N
N
VE
L
V
S
I
E
N
L
P
GRI
A
AN
SVI
PYPPG
I
P
M
L
LS
GE
N
F
G
D
KNS
P
QV
S
Y
L
R
S
L
Q
S
W
D
H
H
F
PGFE
HETE
G
T
EI-I
DG
I
Y
H
V
M
CV
K
fig|1040638.4.peg.1163
Escherichia coli O104:H4 str. LB226692 (22-755/756)
V
E
R
L
AD
AL
SQ
QN
VTV
I
K
S
T
S
F
DD
GFA
I
LS
S
N
E
A
I
DCLM
F
SYQ
M
E
H
P
D
EH
Q
N
V
R
QL
IGKLHERQQ
N
V
P
VFLL
G
DR
E
KA
L
AAM
DR
---
DL
L
E
-----
L
V
D
E
F
AWI
L
ED
T
A
DF
IA
G
R
AV
A
A
M
T
R
Y
RQQ
L
LPPL
FS
AL
M
KY
S
D
I
H
E
Y
SWAA
PGH
Q
GG
VG
F
T
K
T
P
A
G
R
FYH
D
YY
G
E
N
L
F
R
T
D
M
G
I
ER
T
S
LGSLLDHTG
AF
G
E
S
E
K
Y
A
ARVFGADRS
W
S
V
VV
GTS
G
SN
RTIMQA
C
MT
D
NDV
V
VV
DRNCHKS
I
E
QG
LM
L
T
GA
K
PVY
MV
P
S
RN
R
YGI
I
G
P
I
Y
PQ
E
M
Q
PE
T
L
Q
KK
I
S
E
S
P
LTKDK
A
G
Q
K
P
SYC
V
V
TN
C
TYDG
VC
YN
AK
E
AQ
D
L
L
EK
T
S
DRL
HFD
E
AW
YG
Y
A
R
F
N
PIY
A
DH
Y
A
M
R
GE
--
PGDH
N
G
PTV
F
A
T
H
STHKLL
N
ALSQAS
Y
IHV
REG
-
R
G
AI
N
FS
R
FN
Q
AYMMH
A
TTSP
L
Y
A
I
C
AS
N
DV
A
VS
MM
D
GN
S
G
LS
L
TQ
E
V
I
DE
A
V
D
FR
QA
M
A
---
RL
Y
K
E
FTADGS
WFF
K
P
W
NK
EV
V
T
D
PQTGKTYDFADAPTKLLTTV
Q
D
CW
V
M
H
PGE
S
WHGF
--
KDI
P
D
N
WS
M
LDPIKV
S
IL
A
PGM
G
EDG
E
LE
E
T
G
V
PAALV
TA
W
L
GR
HGIV
PTR
T
TDFQIM
FLFS
M
G
VTRG
K
W
GT
L
VN
T
L
C
S
FKR
H
YD
A
N
TP
L
AQVM
P
E
L
V
E
QY
PD
T
Y
A
NM
G
I
H
DL
GD
T
MFAWL
KE
N
N
PG
A
RL
N
E
A
Y
SG
LP
M
A
E
I
TP
RE
A
Y
N
AI
V
D
N
N
VE
L
V
S
I
E
N
L
P
GRI
A
AN
SVI
PYPPG
I
P
M
L
LS
GE
N
F
G
D
KNS
P
QV
S
Y
L
R
S
L
Q
S
W
D
H
H
F
PGFE
HETE
G
T
EI-I
DG
I
Y
H
V
M
CV
K
fig|6666666.5357.peg.783
Escherichia coli TY-2482 (22-755/756)
V
E
R
L
AD
AL
SQ
QN
VTV
I
K
S
T
S
F
DD
GFA
I
LS
S
N
E
A
I
DCLM
F
SYQ
M
E
H
P
D
EH
Q
N
V
R
QL
IGKLHERQQ
N
V
P
VFLL
G
DR
E
KA
L
AAM
DR
---
DL
L
E
-----
L
V
D
E
F
AWI
L
ED
T
A
DF
IA
G
R
AV
A
A
M
T
R
Y
RQQ
L
LPPL
FS
AL
M
KY
S
D
I
H
E
Y
SWAA
PGH
Q
GG
VG
F
T
K
T
P
A
G
R
FYH
D
YY
G
E
N
L
F
R
T
D
M
G
I
ER
T
S
LGSLLDHTG
AF
G
E
S
E
K
Y
A
ARVFGADRS
W
S
V
VV
GTS
G
SN
RTIMQA
C
MT
D
NDV
V
VV
DRNCHKS
I
E
QG
LM
L
T
GA
K
PVY
MV
P
S
RN
R
YGI
I
G
P
I
Y
PQ
E
M
Q
PE
T
L
Q
KK
I
S
E
S
P
LTKDK
A
G
Q
K
P
SYC
V
V
TN
C
TYDG
VC
YN
AK
E
AQ
D
L
L
EK
T
S
DRL
HFD
E
AW
YG
Y
A
R
F
N
PIY
A
DH
Y
A
M
R
GE
--
PGDH
N
G
PTV
F
A
T
H
STHKLL
N
ALSQAS
Y
IHV
REG
-
R
G
AI
N
FS
R
FN
Q
AYMMH
A
TTSP
L
Y
A
I
C
AS
N
DV
A
VS
MM
D
GN
S
G
LS
L
TQ
E
V
I
DE
A
V
D
FR
QA
M
A
---
RL
Y
K
E
FTADGS
WFF
K
P
W
NK
EV
V
T
D
PQTGKTYDFADAPTKLLTTV
Q
D
CW
V
M
H
PGE
S
WHGF
--
KDI
P
D
N
WS
M
LDPIKV
S
IL
A
PGM
G
EDG
E
LE
E
T
G
V
PAALV
TA
W
L
GR
HGIV
PTR
T
TDFQIM
FLFS
M
G
VTRG
K
W
GT
L
VN
T
L
C
S
FKR
H
YD
A
N
TP
L
AQVM
P
E
L
V
E
QY
PD
T
Y
A
NM
G
I
H
DL
GD
T
MFAWL
KE
N
N
PG
A
RL
N
E
A
Y
SG
LP
M
A
E
I
TP
RE
A
Y
N
AI
V
D
N
N
VE
L
V
S
I
E
N
L
P
GRI
A
AN
SVI
PYPPG
I
P
M
L
LS
GE
N
F
G
D
KNS
P
QV
S
Y
L
R
S
L
Q
S
W
D
H
H
F
PGFE
HETE
G
T
EI-I
DG
I
Y
H
V
M
CV
K
fig|585055.6.peg.4633
Escherichia coli 55989 (22-755/756)
V
E
R
L
AD
AL
SQ
QN
VTV
I
K
S
T
S
F
DD
GFA
I
LS
S
N
E
A
I
DCLM
F
SYQ
M
E
H
P
D
EH
Q
N
V
R
QL
IGKLHERQQ
N
V
P
VFLL
G
DR
E
KA
L
AAM
DR
---
DL
L
E
-----
L
V
D
E
F
AWI
L
ED
T
A
DF
IA
G
R
AV
A
A
M
T
R
Y
RQQ
L
LPPL
FS
AL
M
KY
S
D
I
H
E
Y
SWAA
PGH
Q
GG
VG
F
T
K
T
P
A
G
R
FYH
D
YY
G
E
N
L
F
R
T
D
M
G
I
ER
T
S
LGSLLDHTG
AF
G
E
S
E
K
Y
A
ARVFGADRS
W
S
V
VV
GTS
G
SN
RTIMQA
C
MT
D
NDV
V
VV
DRNCHKS
I
E
QG
LM
L
T
GA
K
PVY
MV
P
S
RN
R
YGI
I
G
P
I
Y
PQ
E
M
Q
PE
T
L
Q
KK
I
S
E
S
P
LTKDK
A
G
Q
K
P
SYC
V
V
TN
C
TYDG
VC
YN
AK
E
AQ
D
L
L
EK
T
S
DRL
HFD
E
AW
YG
Y
A
R
F
N
PIY
A
DH
Y
A
M
R
GE
--
PGDH
N
G
PTV
F
A
T
H
STHKLL
N
ALSQAS
Y
IHV
REG
-
R
G
AI
N
FS
R
FN
Q
AYMMH
A
TTSP
L
Y
A
I
C
AS
N
DV
A
VS
MM
D
GN
S
G
LS
L
TQ
E
V
I
DE
A
V
D
FR
QA
M
A
---
RL
Y
K
E
FTADGS
WFF
K
P
W
NK
EV
V
T
D
PQTGKTYDFADAPTKLLTTV
Q
D
CW
V
M
H
PGE
S
WHGF
--
KDI
P
D
N
WS
M
LDPIKV
S
IL
A
PGM
G
EDG
E
LE
E
T
G
V
PAALV
TA
W
L
GR
HGIV
PTR
T
TDFQIM
FLFS
M
G
VTRG
K
W
GT
L
VN
T
L
C
S
FKR
H
YD
A
N
TP
L
AQVM
P
E
L
V
E
QY
PD
T
Y
A
NM
G
I
H
DL
GD
T
MFAWL
KE
N
N
PG
A
RL
N
E
A
Y
SG
LP
M
A
E
I
TP
RE
A
Y
N
AI
V
D
N
N
VE
L
V
S
I
E
N
L
P
GRI
A
AN
SVI
PYPPG
I
P
M
L
LS
GE
N
F
G
D
KNS
P
QV
S
Y
L
R
S
L
Q
S
W
D
H
H
F
PGFE
HETE
G
T
EI-I
DG
I
Y
H
V
M
CV
K
fig|585055.8.peg.4638
Escherichia coli 55989 (22-755/756)
V
E
R
L
AD
AL
SQ
QN
VTV
I
K
S
T
S
F
DD
GFA
I
LS
S
N
E
A
I
DCLM
F
SYQ
M
E
H
P
D
EH
Q
N
V
R
QL
IGKLHERQQ
N
V
P
VFLL
G
DR
E
KA
L
AAM
DR
---
DL
L
E
-----
L
V
D
E
F
AWI
L
ED
T
A
DF
IA
G
R
AV
A
A
M
T
R
Y
RQQ
L
LPPL
FS
AL
M
KY
S
D
I
H
E
Y
SWAA
PGH
Q
GG
VG
F
T
K
T
P
A
G
R
FYH
D
YY
G
E
N
L
F
R
T
D
M
G
I
ER
T
S
LGSLLDHTG
AF
G
E
S
E
K
Y
A
ARVFGADRS
W
S
V
VV
GTS
G
SN
RTIMQA
C
MT
D
NDV
V
VV
DRNCHKS
I
E
QG
LM
L
T
GA
K
PVY
MV
P
S
RN
R
YGI
I
G
P
I
Y
PQ
E
M
Q
PE
T
L
Q
KK
I
S
E
S
P
LTKDK
A
G
Q
K
P
SYC
V
V
TN
C
TYDG
VC
YN
AK
E
AQ
D
L
L
EK
T
S
DRL
HFD
E
AW
YG
Y
A
R
F
N
PIY
A
DH
Y
A
M
R
GE
--
PGDH
N
G
PTV
F
A
T
H
STHKLL
N
ALSQAS
Y
IHV
REG
-
R
G
AI
N
FS
R
FN
Q
AYMMH
A
TTSP
L
Y
A
I
C
AS
N
DV
A
VS
MM
D
GN
S
G
LS
L
TQ
E
V
I
DE
A
V
D
FR
QA
M
A
---
RL
Y
K
E
FTADGS
WFF
K
P
W
NK
EV
V
T
D
PQTGKTYDFADAPTKLLTTV
Q
D
CW
V
M
H
PGE
S
WHGF
--
KDI
P
D
N
WS
M
LDPIKV
S
IL
A
PGM
G
EDG
E
LE
E
T
G
V
PAALV
TA
W
L
GR
HGIV
PTR
T
TDFQIM
FLFS
M
G
VTRG
K
W
GT
L
VN
T
L
C
S
FKR
H
YD
A
N
TP
L
AQVM
P
E
L
V
E
QY
PD
T
Y
A
NM
G
I
H
DL
GD
T
MFAWL
KE
N
N
PG
A
RL
N
E
A
Y
SG
LP
M
A
E
I
TP
RE
A
Y
N
AI
V
D
N
N
VE
L
V
S
I
E
N
L
P
GRI
A
AN
SVI
PYPPG
I
P
M
L
LS
GE
N
F
G
D
KNS
P
QV
S
Y
L
R
S
L
Q
S
W
D
H
H
F
PGFE
HETE
G
T
EI-I
DG
I
Y
H
V
M
CV
K
fig|550672.3.peg.4196
Escherichia coli B088 (22-755/756)
V
E
R
L
AD
AL
SQ
QN
VTV
I
K
S
T
S
F
DD
GFA
I
LS
S
N
E
A
I
DCLM
F
SYQ
M
E
H
P
D
EH
Q
N
V
R
QL
IGKLHERQQ
N
V
P
VFLL
G
DR
E
KA
L
AAM
DR
---
DL
L
E
-----
L
V
D
E
F
AWI
L
ED
T
A
DF
IA
G
R
AV
A
A
M
T
R
Y
RQQ
L
LPPL
FS
AL
M
KY
S
D
I
H
E
Y
SWAA
PGH
Q
GG
VG
F
T
K
T
P
A
G
R
FYH
D
YY
G
E
N
L
F
R
T
D
M
G
I
ER
T
S
LGSLLDHTG
AF
G
E
S
E
K
Y
A
ARVFGADRS
W
S
V
VV
GTS
G
SN
RTIMQA
C
MT
D
NDV
V
VV
DRNCHKS
I
E
QG
LM
L
T
GA
K
PVY
MV
P
S
RN
R
YGI
I
G
P
I
Y
PQ
E
M
Q
PE
T
L
Q
KK
I
S
E
S
P
LTKDK
A
G
Q
K
P
SYC
V
V
TN
C
TYDG
VC
YN
AK
E
AQ
D
L
L
EK
T
S
DRL
HFD
E
AW
YG
Y
A
R
F
N
PIY
A
DH
Y
A
M
R
GE
--
PGDH
N
G
PTV
F
A
T
H
STHKLL
N
ALSQAS
Y
IHV
REG
-
R
G
AI
N
FS
R
FN
Q
AYMMH
A
TTSP
L
Y
A
I
C
AS
N
DV
A
VS
MM
D
GN
S
G
LS
L
TQ
E
V
I
DE
A
V
D
FR
QA
M
A
---
RL
Y
K
E
FTADGS
WFF
K
P
W
NK
EV
V
T
D
PQTGKTYDFADAPTKLLTTV
Q
D
CW
V
M
H
PGE
S
WHGF
--
KDI
P
D
N
WS
M
LDPIKV
S
IL
A
PGM
G
EDG
E
LE
E
T
G
V
PAALV
TA
W
L
GR
HGIV
PTR
T
TDFQIM
FLFS
M
G
VTRG
K
W
GT
L
VN
T
L
C
S
FKR
H
YD
A
N
TP
L
AQVM
P
E
L
V
E
QY
PD
T
Y
A
NM
G
I
H
DL
GD
T
MFAWL
KE
N
N
PG
A
RL
N
E
A
Y
SG
LP
M
A
E
I
TP
RE
A
Y
N
AI
V
D
N
N
VE
L
V
S
I
E
N
L
P
GRI
A
AN
SVI
PYPPG
I
P
M
L
LS
GE
N
F
G
D
KNS
P
QV
S
Y
L
R
S
L
Q
S
W
D
H
H
F
PGFE
HETE
G
T
EI-I
DG
I
Y
H
V
M
CV
K
fig|340184.3.peg.716
Escherichia coli B7A (22-755/756)
V
E
R
L
AD
AL
SQ
QN
VTV
I
K
S
T
S
F
DD
GFA
I
LS
S
N
E
A
I
DCLM
F
SYQ
M
E
H
P
D
EH
Q
N
V
R
QL
IGKLHERQQ
N
V
P
VFLL
G
DR
E
KA
L
AAM
DR
---
DL
L
E
-----
L
V
D
E
F
AWI
L
ED
T
A
DF
IA
G
R
AV
A
A
M
T
R
Y
RQQ
L
LPPL
FS
AL
M
KY
S
D
I
H
E
Y
SWAA
PGH
Q
GG
VG
F
T
K
T
P
A
G
R
FYH
D
YY
G
E
N
L
F
R
T
D
M
G
I
ER
T
S
LGSLLDHTG
AF
G
E
S
E
K
Y
A
ARVFGADRS
W
S
V
VV
GTS
G
SN
RTIMQA
C
MT
D
NDV
V
VV
DRNCHKS
I
E
QG
LM
L
T
GA
K
PVY
MV
P
S
RN
R
YGI
I
G
P
I
Y
PQ
E
M
Q
PE
T
L
Q
KK
I
S
E
S
P
LTKDK
A
G
Q
K
P
SYC
V
V
TN
C
TYDG
VC
YN
AK
E
AQ
D
L
L
EK
T
S
DRL
HFD
E
AW
YG
Y
A
R
F
N
PIY
A
DH
Y
A
M
R
GE
--
PGDH
N
G
PTV
F
A
T
H
STHKLL
N
ALSQAS
Y
IHV
REG
-
R
G
AI
N
FS
R
FN
Q
AYMMH
A
TTSP
L
Y
A
I
C
AS
N
DV
A
VS
MM
D
GN
S
G
LS
L
TQ
E
V
I
DE
A
V
D
FR
QA
M
A
---
RL
Y
K
E
FTADGS
WFF
K
P
W
NK
EV
V
T
D
PQTGKTYDFADAPTKLLTTV
Q
D
CW
V
M
H
PGE
S
WHGF
--
KDI
P
D
N
WS
M
LDPIKV
S
IL
A
PGM
G
EDG
E
LE
E
T
G
V
PAALV
TA
W
L
GR
HGIV
PTR
T
TDFQIM
FLFS
M
G
VTRG
K
W
GT
L
VN
T
L
C
S
FKR
H
YD
A
N
TP
L
AQVM
P
E
L
V
E
QY
PD
T
Y
A
NM
G
I
H
DL
GD
T
MFAWL
KE
N
N
PG
A
RL
N
E
A
Y
SG
LP
M
A
E
I
TP
RE
A
Y
N
AI
V
D
N
N
VE
L
V
S
I
E
N
L
P
GRI
A
AN
SVI
PYPPG
I
P
M
L
LS
GE
N
F
G
D
KNS
P
QV
S
Y
L
R
S
L
Q
S
W
D
H
H
F
PGFE
HETE
G
T
EI-I
DG
I
Y
H
V
M
CV
K
fig|340184.6.peg.747
Escherichia coli B7A (22-755/756)
V
E
R
L
AD
AL
SQ
QN
VTV
I
K
S
T
S
F
DD
GFA
I
LS
S
N
E
A
I
DCLM
F
SYQ
M
E
H
P
D
EH
Q
N
V
R
QL
IGKLHERQQ
N
V
P
VFLL
G
DR
E
KA
L
AAM
DR
---
DL
L
E
-----
L
V
D
E
F
AWI
L
ED
T
A
DF
IA
G
R
AV
A
A
M
T
R
Y
RQQ
L
LPPL
FS
AL
M
KY
S
D
I
H
E
Y
SWAA
PGH
Q
GG
VG
F
T
K
T
P
A
G
R
FYH
D
YY
G
E
N
L
F
R
T
D
M
G
I
ER
T
S
LGSLLDHTG
AF
G
E
S
E
K
Y
A
ARVFGADRS
W
S
V
VV
GTS
G
SN
RTIMQA
C
MT
D
NDV
V
VV
DRNCHKS
I
E
QG
LM
L
T
GA
K
PVY
MV
P
S
RN
R
YGI
I
G
P
I
Y
PQ
E
M
Q
PE
T
L
Q
KK
I
S
E
S
P
LTKDK
A
G
Q
K
P
SYC
V
V
TN
C
TYDG
VC
YN
AK
E
AQ
D
L
L
EK
T
S
DRL
HFD
E
AW
YG
Y
A
R
F
N
PIY
A
DH
Y
A
M
R
GE
--
PGDH
N
G
PTV
F
A
T
H
STHKLL
N
ALSQAS
Y
IHV
REG
-
R
G
AI
N
FS
R
FN
Q
AYMMH
A
TTSP
L
Y
A
I
C
AS
N
DV
A
VS
MM
D
GN
S
G
LS
L
TQ
E
V
I
DE
A
V
D
FR
QA
M
A
---
RL
Y
K
E
FTADGS
WFF
K
P
W
NK
EV
V
T
D
PQTGKTYDFADAPTKLLTTV
Q
D
CW
V
M
H
PGE
S
WHGF
--
KDI
P
D
N
WS
M
LDPIKV
S
IL
A
PGM
G
EDG
E
LE
E
T
G
V
PAALV
TA
W
L
GR
HGIV
PTR
T
TDFQIM
FLFS
M
G
VTRG
K
W
GT
L
VN
T
L
C
S
FKR
H
YD
A
N
TP
L
AQVM
P
E
L
V
E
QY
PD
T
Y
A
NM
G
I
H
DL
GD
T
MFAWL
KE
N
N
PG
A
RL
N
E
A
Y
SG
LP
M
A
E
I
TP
RE
A
Y
N
AI
V
D
N
N
VE
L
V
S
I
E
N
L
P
GRI
A
AN
SVI
PYPPG
I
P
M
L
LS
GE
N
F
G
D
KNS
P
QV
S
Y
L
R
S
L
Q
S
W
D
H
H
F
PGFE
HETE
G
T
EI-I
DG
I
Y
H
V
M
CV
K
fig|340186.3.peg.1043
Escherichia coli E110019 (22-755/756)
V
E
R
L
AD
AL
SQ
QN
VTV
I
K
S
T
S
F
DD
GFA
I
LS
S
N
E
A
I
DCLM
F
SYQ
M
E
H
P
D
EH
Q
N
V
R
QL
IGKLHERQQ
N
V
P
VFLL
G
DR
E
KA
L
AAM
DR
---
DL
L
E
-----
L
V
D
E
F
AWI
L
ED
T
A
DF
IA
G
R
AV
A
A
M
T
R
Y
RQQ
L
LPPL
FS
AL
M
KY
S
D
I
H
E
Y
SWAA
PGH
Q
GG
VG
F
T
K
T
P
A
G
R
FYH
D
YY
G
E
N
L
F
R
T
D
M
G
I
ER
T
S
LGSLLDHTG
AF
G
E
S
E
K
Y
A
ARVFGADRS
W
S
V
VV
GTS
G
SN
RTIMQA
C
MT
D
NDV
V
VV
DRNCHKS
I
E
QG
LM
L
T
GA
K
PVY
MV
P
S
RN
R
YGI
I
G
P
I
Y
PQ
E
M
Q
PE
T
L
Q
KK
I
S
E
S
P
LTKDK
A
G
Q
K
P
SYC
V
V
TN
C
TYDG
VC
YN
AK
E
AQ
D
L
L
EK
T
S
DRL
HFD
E
AW
YG
Y
A
R
F
N
PIY
A
DH
Y
A
M
R
GE
--
PGDH
N
G
PTV
F
A
T
H
STHKLL
N
ALSQAS
Y
IHV
REG
-
R
G
AI
N
FS
R
FN
Q
AYMMH
A
TTSP
L
Y
A
I
C
AS
N
DV
A
VS
MM
D
GN
S
G
LS
L
TQ
E
V
I
DE
A
V
D
FR
QA
M
A
---
RL
Y
K
E
FTADGS
WFF
K
P
W
NK
EV
V
T
D
PQTGKTYDFADAPTKLLTTV
Q
D
CW
V
M
H
PGE
S
WHGF
--
KDI
P
D
N
WS
M
LDPIKV
S
IL
A
PGM
G
EDG
E
LE
E
T
G
V
PAALV
TA
W
L
GR
HGIV
PTR
T
TDFQIM
FLFS
M
G
VTRG
K
W
GT
L
VN
T
L
C
S
FKR
H
YD
A
N
TP
L
AQVM
P
E
L
V
E
QY
PD
T
Y
A
NM
G
I
H
DL
GD
T
MFAWL
KE
N
N
PG
A
RL
N
E
A
Y
SG
LP
M
A
E
I
TP
RE
A
Y
N
AI
V
D
N
N
VE
L
V
S
I
E
N
L
P
GRI
A
AN
SVI
PYPPG
I
P
M
L
LS
GE
N
F
G
D
KNS
P
QV
S
Y
L
R
S
L
Q
S
W
D
H
H
F
PGFE
HETE
G
T
EI-I
DG
I
Y
H
V
M
CV
K
fig|340186.5.peg.1084
Escherichia coli E110019 (22-755/756)
V
E
R
L
AD
AL
SQ
QN
VTV
I
K
S
T
S
F
DD
GFA
I
LS
S
N
E
A
I
DCLM
F
SYQ
M
E
H
P
D
EH
Q
N
V
R
QL
IGKLHERQQ
N
V
P
VFLL
G
DR
E
KA
L
AAM
DR
---
DL
L
E
-----
L
V
D
E
F
AWI
L
ED
T
A
DF
IA
G
R
AV
A
A
M
T
R
Y
RQQ
L
LPPL
FS
AL
M
KY
S
D
I
H
E
Y
SWAA
PGH
Q
GG
VG
F
T
K
T
P
A
G
R
FYH
D
YY
G
E
N
L
F
R
T
D
M
G
I
ER
T
S
LGSLLDHTG
AF
G
E
S
E
K
Y
A
ARVFGADRS
W
S
V
VV
GTS
G
SN
RTIMQA
C
MT
D
NDV
V
VV
DRNCHKS
I
E
QG
LM
L
T
GA
K
PVY
MV
P
S
RN
R
YGI
I
G
P
I
Y
PQ
E
M
Q
PE
T
L
Q
KK
I
S
E
S
P
LTKDK
A
G
Q
K
P
SYC
V
V
TN
C
TYDG
VC
YN
AK
E
AQ
D
L
L
EK
T
S
DRL
HFD
E
AW
YG
Y
A
R
F
N
PIY
A
DH
Y
A
M
R
GE
--
PGDH
N
G
PTV
F
A
T
H
STHKLL
N
ALSQAS
Y
IHV
REG
-
R
G
AI
N
FS
R
FN
Q
AYMMH
A
TTSP
L
Y
A
I
C
AS
N
DV
A
VS
MM
D
GN
S
G
LS
L
TQ
E
V
I
DE
A
V
D
FR
QA
M
A
---
RL
Y
K
E
FTADGS
WFF
K
P
W
NK
EV
V
T
D
PQTGKTYDFADAPTKLLTTV
Q
D
CW
V
M
H
PGE
S
WHGF
--
KDI
P
D
N
WS
M
LDPIKV
S
IL
A
PGM
G
EDG
E
LE
E
T
G
V
PAALV
TA
W
L
GR
HGIV
PTR
T
TDFQIM
FLFS
M
G
VTRG
K
W
GT
L
VN
T
L
C
S
FKR
H
YD
A
N
TP
L
AQVM
P
E
L
V
E
QY
PD
T
Y
A
NM
G
I
H
DL
GD
T
MFAWL
KE
N
N
PG
A
RL
N
E
A
Y
SG
LP
M
A
E
I
TP
RE
A
Y
N
AI
V
D
N
N
VE
L
V
S
I
E
N
L
P
GRI
A
AN
SVI
PYPPG
I
P
M
L
LS
GE
N
F
G
D
KNS
P
QV
S
Y
L
R
S
L
Q
S
W
D
H
H
F
PGFE
HETE
G
T
EI-I
DG
I
Y
H
V
M
CV
K
fig|331111.12.peg.4879
Escherichia coli E24377A (22-755/756)
V
E
R
L
AD
AL
SQ
QN
VTV
I
K
S
T
S
F
DD
GFA
I
LS
S
N
E
A
I
DCLM
F
SYQ
M
E
H
P
D
EH
Q
N
V
R
QL
IGKLHERQQ
N
V
P
VFLL
G
DR
E
KA
L
AAM
DR
---
DL
L
E
-----
L
V
D
E
F
AWI
L
ED
T
A
DF
IA
G
R
AV
A
A
M
T
R
Y
RQQ
L
LPPL
FS
AL
M
KY
S
D
I
H
E
Y
SWAA
PGH
Q
GG
VG
F
T
K
T
P
A
G
R
FYH
D
YY
G
E
N
L
F
R
T
D
M
G
I
ER
T
S
LGSLLDHTG
AF
G
E
S
E
K
Y
A
ARVFGADRS
W
S
V
VV
GTS
G
SN
RTIMQA
C
MT
D
NDV
V
VV
DRNCHKS
I
E
QG
LM
L
T
GA
K
PVY
MV
P
S
RN
R
YGI
I
G
P
I
Y
PQ
E
M
Q
PE
T
L
Q
KK
I
S
E
S
P
LTKDK
A
G
Q
K
P
SYC
V
V
TN
C
TYDG
VC
YN
AK
E
AQ
D
L
L
EK
T
S
DRL
HFD
E
AW
YG
Y
A
R
F
N
PIY
A
DH
Y
A
M
R
GE
--
PGDH
N
G
PTV
F
A
T
H
STHKLL
N
ALSQAS
Y
IHV
REG
-
R
G
AI
N
FS
R
FN
Q
AYMMH
A
TTSP
L
Y
A
I
C
AS
N
DV
A
VS
MM
D
GN
S
G
LS
L
TQ
E
V
I
DE
A
V
D
FR
QA
M
A
---
RL
Y
K
E
FTADGS
WFF
K
P
W
NK
EV
V
T
D
PQTGKTYDFADAPTKLLTTV
Q
D
CW
V
M
H
PGE
S
WHGF
--
KDI
P
D
N
WS
M
LDPIKV
S
IL
A
PGM
G
EDG
E
LE
E
T
G
V
PAALV
TA
W
L
GR
HGIV
PTR
T
TDFQIM
FLFS
M
G
VTRG
K
W
GT
L
VN
T
L
C
S
FKR
H
YD
A
N
TP
L
AQVM
P
E
L
V
E
QY
PD
T
Y
A
NM
G
I
H
DL
GD
T
MFAWL
KE
N
N
PG
A
RL
N
E
A
Y
SG
LP
M
A
E
I
TP
RE
A
Y
N
AI
V
D
N
N
VE
L
V
S
I
E
N
L
P
GRI
A
AN
SVI
PYPPG
I
P
M
L
LS
GE
N
F
G
D
KNS
P
QV
S
Y
L
R
S
L
Q
S
W
D
H
H
F
PGFE
HETE
G
T
EI-I
DG
I
Y
H
V
M
CV
K
fig|331111.3.peg.2270
Escherichia coli E24377A (22-755/756)
V
E
R
L
AD
AL
SQ
QN
VTV
I
K
S
T
S
F
DD
GFA
I
LS
S
N
E
A
I
DCLM
F
SYQ
M
E
H
P
D
EH
Q
N
V
R
QL
IGKLHERQQ
N
V
P
VFLL
G
DR
E
KA
L
AAM
DR
---
DL
L
E
-----
L
V
D
E
F
AWI
L
ED
T
A
DF
IA
G
R
AV
A
A
M
T
R
Y
RQQ
L
LPPL
FS
AL
M
KY
S
D
I
H
E
Y
SWAA
PGH
Q
GG
VG
F
T
K
T
P
A
G
R
FYH
D
YY
G
E
N
L
F
R
T
D
M
G
I
ER
T
S
LGSLLDHTG
AF
G
E
S
E
K
Y
A
ARVFGADRS
W
S
V
VV
GTS
G
SN
RTIMQA
C
MT
D
NDV
V
VV
DRNCHKS
I
E
QG
LM
L
T
GA
K
PVY
MV
P
S
RN
R
YGI
I
G
P
I
Y
PQ
E
M
Q
PE
T
L
Q
KK
I
S
E
S
P
LTKDK
A
G
Q
K
P
SYC
V
V
TN
C
TYDG
VC
YN
AK
E
AQ
D
L
L
EK
T
S
DRL
HFD
E
AW
YG
Y
A
R
F
N
PIY
A
DH
Y
A
M
R
GE
--
PGDH
N
G
PTV
F
A
T
H
STHKLL
N
ALSQAS
Y
IHV
REG
-
R
G
AI
N
FS
R
FN
Q
AYMMH
A
TTSP
L
Y
A
I
C
AS
N
DV
A
VS
MM
D
GN
S
G
LS
L
TQ
E
V
I
DE
A
V
D
FR
QA
M
A
---
RL
Y
K
E
FTADGS
WFF
K
P
W
NK
EV
V
T
D
PQTGKTYDFADAPTKLLTTV
Q
D
CW
V
M
H
PGE
S
WHGF
--
KDI
P
D
N
WS
M
LDPIKV
S
IL
A
PGM
G
EDG
E
LE
E
T
G
V
PAALV
TA
W
L
GR
HGIV
PTR
T
TDFQIM
FLFS
M
G
VTRG
K
W
GT
L
VN
T
L
C
S
FKR
H
YD
A
N
TP
L
AQVM
P
E
L
V
E
QY
PD
T
Y
A
NM
G
I
H
DL
GD
T
MFAWL
KE
N
N
PG
A
RL
N
E
A
Y
SG
LP
M
A
E
I
TP
RE
A
Y
N
AI
V
D
N
N
VE
L
V
S
I
E
N
L
P
GRI
A
AN
SVI
PYPPG
I
P
M
L
LS
GE
N
F
G
D
KNS
P
QV
S
Y
L
R
S
L
Q
S
W
D
H
H
F
PGFE
HETE
G
T
EI-I
DG
I
Y
H
V
M
CV
K
fig|562.375.peg.2961
Escherichia coli EC4100B (22-755/756)
V
E
R
L
AD
AL
SQ
QN
VTV
I
K
S
T
S
F
DD
GFA
I
LS
S
N
E
A
I
DCLM
F
SYQ
M
E
H
P
D
EH
Q
N
V
R
QL
IGKLHERQQ
N
V
P
VFLL
G
DR
E
KA
L
AAM
DR
---
DL
L
E
-----
L
V
D
E
F
AWI
L
ED
T
A
DF
IA
G
R
AV
A
A
M
T
R
Y
RQQ
L
LPPL
FS
AL
M
KY
S
D
I
H
E
Y
SWAA
PGH
Q
GG
VG
F
T
K
T
P
A
G
R
FYH
D
YY
G
E
N
L
F
R
T
D
M
G
I
ER
T
S
LGSLLDHTG
AF
G
E
S
E
K
Y
A
ARVFGADRS
W
S
V
VV
GTS
G
SN
RTIMQA
C
MT
D
NDV
V
VV
DRNCHKS
I
E
QG
LM
L
T
GA
K
PVY
MV
P
S
RN
R
YGI
I
G
P
I
Y
PQ
E
M
Q
PE
T
L
Q
KK
I
S
E
S
P
LTKDK
A
G
Q
K
P
SYC
V
V
TN
C
TYDG
VC
YN
AK
E
AQ
D
L
L
EK
T
S
DRL
HFD
E
AW
YG
Y
A
R
F
N
PIY
A
DH
Y
A
M
R
GE
--
PGDH
N
G
PTV
F
A
T
H
STHKLL
N
ALSQAS
Y
IHV
REG
-
R
G
AI
N
FS
R
FN
Q
AYMMH
A
TTSP
L
Y
A
I
C
AS
N
DV
A
VS
MM
D
GN
S
G
LS
L
TQ
E
V
I
DE
A
V
D
FR
QA
M
A
---
RL
Y
K
E
FTADGS
WFF
K
P
W
NK
EV
V
T
D
PQTGKTYDFADAPTKLLTTV
Q
D
CW
V
M
H
PGE
S
WHGF
--
KDI
P
D
N
WS
M
LDPIKV
S
IL
A
PGM
G
EDG
E
LE
E
T
G
V
PAALV
TA
W
L
GR
HGIV
PTR
T
TDFQIM
FLFS
M
G
VTRG
K
W
GT
L
VN
T
L
C
S
FKR
H
YD
A
N
TP
L
AQVM
P
E
L
V
E
QY
PD
T
Y
A
NM
G
I
H
DL
GD
T
MFAWL
KE
N
N
PG
A
RL
N
E
A
Y
SG
LP
M
A
E
I
TP
RE
A
Y
N
AI
V
D
N
N
VE
L
V
S
I
E
N
L
P
GRI
A
AN
SVI
PYPPG
I
P
M
L
LS
GE
N
F
G
D
KNS
P
QV
S
Y
L
R
S
L
Q
S
W
D
H
H
F
PGFE
HETE
G
T
EI-I
DG
I
Y
H
V
M
CV
K
fig|656408.3.peg.4614
Escherichia coli H591 (22-755/756)
V
E
R
L
AD
AL
SQ
QN
VTV
I
K
S
T
S
F
DD
GFA
I
LS
S
N
E
A
I
DCLM
F
SYQ
M
E
H
P
D
EH
Q
N
V
R
QL
IGKLHERQQ
N
V
P
VFLL
G
DR
E
KA
L
AAM
DR
---
DL
L
E
-----
L
V
D
E
F
AWI
L
ED
T
A
DF
IA
G
R
AV
A
A
M
T
R
Y
RQQ
L
LPPL
FS
AL
M
KY
S
D
I
H
E
Y
SWAA
PGH
Q
GG
VG
F
T
K
T
P
A
G
R
FYH
D
YY
G
E
N
L
F
R
T
D
M
G
I
ER
T
S
LGSLLDHTG
AF
G
E
S
E
K
Y
A
ARVFGADRS
W
S
V
VV
GTS
G
SN
RTIMQA
C
MT
D
NDV
V
VV
DRNCHKS
I
E
QG
LM
L
T
GA
K
PVY
MV
P
S
RN
R
YGI
I
G
P
I
Y
PQ
E
M
Q
PE
T
L
Q
KK
I
S
E
S
P
LTKDK
A
G
Q
K
P
SYC
V
V
TN
C
TYDG
VC
YN
AK
E
AQ
D
L
L
EK
T
S
DRL
HFD
E
AW
YG
Y
A
R
F
N
PIY
A
DH
Y
A
M
R
GE
--
PGDH
N
G
PTV
F
A
T
H
STHKLL
N
ALSQAS
Y
IHV
REG
-
R
G
AI
N
FS
R
FN
Q
AYMMH
A
TTSP
L
Y
A
I
C
AS
N
DV
A
VS
MM
D
GN
S
G
LS
L
TQ
E
V
I
DE
A
V
D
FR
QA
M
A
---
RL
Y
K
E
FTADGS
WFF
K
P
W
NK
EV
V
T
D
PQTGKTYDFADAPTKLLTTV
Q
D
CW
V
M
H
PGE
S
WHGF
--
KDI
P
D
N
WS
M
LDPIKV
S
IL
A
PGM
G
EDG
E
LE
E
T
G
V
PAALV
TA
W
L
GR
HGIV
PTR
T
TDFQIM
FLFS
M
G
VTRG
K
W
GT
L
VN
T
L
C
S
FKR
H
YD
A
N
TP
L
AQVM
P
E
L
V
E
QY
PD
T
Y
A
NM
G
I
H
DL
GD
T
MFAWL
KE
N
N
PG
A
RL
N
E
A
Y
SG
LP
M
A
E
I
TP
RE
A
Y
N
AI
V
D
N
N
VE
L
V
S
I
E
N
L
P
GRI
A
AN
SVI
PYPPG
I
P
M
L
LS
GE
N
F
G
D
KNS
P
QV
S
Y
L
R
S
L
Q
S
W
D
H
H
F
PGFE
HETE
G
T
EI-I
DG
I
Y
H
V
M
CV
K
fig|331112.3.peg.4071
Escherichia coli HS (22-755/756)
V
E
R
L
AD
AL
SQ
QN
VTV
I
K
S
T
S
F
DD
GFA
I
LS
S
N
E
A
I
DCLM
F
SYQ
M
E
H
P
D
EH
Q
N
V
R
QL
IGKLHERQQ
N
V
P
VFLL
G
DR
E
KA
L
AAM
DR
---
DL
L
E
-----
L
V
D
E
F
AWI
L
ED
T
A
DF
IA
G
R
AV
A
A
M
T
R
Y
RQQ
L
LPPL
FS
AL
M
KY
S
D
I
H
E
Y
SWAA
PGH
Q
GG
VG
F
T
K
T
P
A
G
R
FYH
D
YY
G
E
N
L
F
R
T
D
M
G
I
ER
T
S
LGSLLDHTG
AF
G
E
S
E
K
Y
A
ARVFGADRS
W
S
V
VV
GTS
G
SN
RTIMQA
C
MT
D
NDV
V
VV
DRNCHKS
I
E
QG
LM
L
T
GA
K
PVY
MV
P
S
RN
R
YGI
I
G
P
I
Y
PQ
E
M
Q
PE
T
L
Q
KK
I
S
E
S
P
LTKDK
A
G
Q
K
P
SYC
V
V
TN
C
TYDG
VC
YN
AK
E
AQ
D
L
L
EK
T
S
DRL
HFD
E
AW
YG
Y
A
R
F
N
PIY
A
DH
Y
A
M
R
GE
--
PGDH
N
G
PTV
F
A
T
H
STHKLL
N
ALSQAS
Y
IHV
REG
-
R
G
AI
N
FS
R
FN
Q
AYMMH
A
TTSP
L
Y
A
I
C
AS
N
DV
A
VS
MM
D
GN
S
G
LS
L
TQ
E
V
I
DE
A
V
D
FR
QA
M
A
---
RL
Y
K
E
FTADGS
WFF
K
P
W
NK
EV
V
T
D
PQTGKTYDFADAPTKLLTTV
Q
D
CW
V
M
H
PGE
S
WHGF
--
KDI
P
D
N
WS
M
LDPIKV
S
IL
A
PGM
G
EDG
E
LE
E
T
G
V
PAALV
TA
W
L
GR
HGIV
PTR
T
TDFQIM
FLFS
M
G
VTRG
K
W
GT
L
VN
T
L
C
S
FKR
H
YD
A
N
TP
L
AQVM
P
E
L
V
E
QY
PD
T
Y
A
NM
G
I
H
DL
GD
T
MFAWL
KE
N
N
PG
A
RL
N
E
A
Y
SG
LP
M
A
E
I
TP
RE
A
Y
N
AI
V
D
N
N
VE
L
V
S
I
E
N
L
P
GRI
A
AN
SVI
PYPPG
I
P
M
L
LS
GE
N
F
G
D
KNS
P
QV
S
Y
L
R
S
L
Q
S
W
D
H
H
F
PGFE
HETE
G
T
EI-I
DG
I
Y
H
V
M
CV
K
fig|331112.6.peg.4246
Escherichia coli HS (22-755/756)
V
E
R
L
AD
AL
SQ
QN
VTV
I
K
S
T
S
F
DD
GFA
I
LS
S
N
E
A
I
DCLM
F
SYQ
M
E
H
P
D
EH
Q
N
V
R
QL
IGKLHERQQ
N
V
P
VFLL
G
DR
E
KA
L
AAM
DR
---
DL
L
E
-----
L
V
D
E
F
AWI
L
ED
T
A
DF
IA
G
R
AV
A
A
M
T
R
Y
RQQ
L
LPPL
FS
AL
M
KY
S
D
I
H
E
Y
SWAA
PGH
Q
GG
VG
F
T
K
T
P
A
G
R
FYH
D
YY
G
E
N
L
F
R
T
D
M
G
I
ER
T
S
LGSLLDHTG
AF
G
E
S
E
K
Y
A
ARVFGADRS
W
S
V
VV
GTS
G
SN
RTIMQA
C
MT
D
NDV
V
VV
DRNCHKS
I
E
QG
LM
L
T
GA
K
PVY
MV
P
S
RN
R
YGI
I
G
P
I
Y
PQ
E
M
Q
PE
T
L
Q
KK
I
S
E
S
P
LTKDK
A
G
Q
K
P
SYC
V
V
TN
C
TYDG
VC
YN
AK
E
AQ
D
L
L
EK
T
S
DRL
HFD
E
AW
YG
Y
A
R
F
N
PIY
A
DH
Y
A
M
R
GE
--
PGDH
N
G
PTV
F
A
T
H
STHKLL
N
ALSQAS
Y
IHV
REG
-
R
G
AI
N
FS
R
FN
Q
AYMMH
A
TTSP
L
Y
A
I
C
AS
N
DV
A
VS
MM
D
GN
S
G
LS
L
TQ
E
V
I
DE
A
V
D
FR
QA
M
A
---
RL
Y
K
E
FTADGS
WFF
K
P
W
NK
EV
V
T
D
PQTGKTYDFADAPTKLLTTV
Q
D
CW
V
M
H
PGE
S
WHGF
--
KDI
P
D
N
WS
M
LDPIKV
S
IL
A
PGM
G
EDG
E
LE
E
T
G
V
PAALV
TA
W
L
GR
HGIV
PTR
T
TDFQIM
FLFS
M
G
VTRG
K
W
GT
L
VN
T
L
C
S
FKR
H
YD
A
N
TP
L
AQVM
P
E
L
V
E
QY
PD
T
Y
A
NM
G
I
H
DL
GD
T
MFAWL
KE
N
N
PG
A
RL
N
E
A
Y
SG
LP
M
A
E
I
TP
RE
A
Y
N
AI
V
D
N
N
VE
L
V
S
I
E
N
L
P
GRI
A
AN
SVI
PYPPG
I
P
M
L
LS
GE
N
F
G
D
KNS
P
QV
S
Y
L
R
S
L
Q
S
W
D
H
H
F
PGFE
HETE
G
T
EI-I
DG
I
Y
H
V
M
CV
K
fig|585034.4.peg.4225
Escherichia coli IAI1 (22-755/756)
V
E
R
L
AD
AL
SQ
QN
VTV
I
K
S
T
S
F
DD
GFA
I
LS
S
N
E
A
I
DCLM
F
SYQ
M
E
H
P
D
EH
Q
N
V
R
QL
IGKLHERQQ
N
V
P
VFLL
G
DR
E
KA
L
AAM
DR
---
DL
L
E
-----
L
V
D
E
F
AWI
L
ED
T
A
DF
IA
G
R
AV
A
A
M
T
R
Y
RQQ
L
LPPL
FS
AL
M
KY
S
D
I
H
E
Y
SWAA
PGH
Q
GG
VG
F
T
K
T
P
A
G
R
FYH
D
YY
G
E
N
L
F
R
T
D
M
G
I
ER
T
S
LGSLLDHTG
AF
G
E
S
E
K
Y
A
ARVFGADRS
W
S
V
VV
GTS
G
SN
RTIMQA
C
MT
D
NDV
V
VV
DRNCHKS
I
E
QG
LM
L
T
GA
K
PVY
MV
P
S
RN
R
YGI
I
G
P
I
Y
PQ
E
M
Q
PE
T
L
Q
KK
I
S
E
S
P
LTKDK
A
G
Q
K
P
SYC
V
V
TN
C
TYDG
VC
YN
AK
E
AQ
D
L
L
EK
T
S
DRL
HFD
E
AW
YG
Y
A
R
F
N
PIY
A
DH
Y
A
M
R
GE
--
PGDH
N
G
PTV
F
A
T
H
STHKLL
N
ALSQAS
Y
IHV
REG
-
R
G
AI
N
FS
R
FN
Q
AYMMH
A
TTSP
L
Y
A
I
C
AS
N
DV
A
VS
MM
D
GN
S
G
LS
L
TQ
E
V
I
DE
A
V
D
FR
QA
M
A
---
RL
Y
K
E
FTADGS
WFF
K
P
W
NK
EV
V
T
D
PQTGKTYDFADAPTKLLTTV
Q
D
CW
V
M
H
PGE
S
WHGF
--
KDI
P
D
N
WS
M
LDPIKV
S
IL
A
PGM
G
EDG
E
LE
E
T
G
V
PAALV
TA
W
L
GR
HGIV
PTR
T
TDFQIM
FLFS
M
G
VTRG
K
W
GT
L
VN
T
L
C
S
FKR
H
YD
A
N
TP
L
AQVM
P
E
L
V
E
QY
PD
T
Y
A
NM
G
I
H
DL
GD
T
MFAWL
KE
N
N
PG
A
RL
N
E
A
Y
SG
LP
M
A
E
I
TP
RE
A
Y
N
AI
V
D
N
N
VE
L
V
S
I
E
N
L
P
GRI
A
AN
SVI
PYPPG
I
P
M
L
LS
GE
N
F
G
D
KNS
P
QV
S
Y
L
R
S
L
Q
S
W
D
H
H
F
PGFE
HETE
G
T
EI-I
DG
I
Y
H
V
M
CV
K
fig|585034.5.peg.4220
Escherichia coli IAI1 (22-755/756)
V
E
R
L
AD
AL
SQ
QN
VTV
I
K
S
T
S
F
DD
GFA
I
LS
S
N
E
A
I
DCLM
F
SYQ
M
E
H
P
D
EH
Q
N
V
R
QL
IGKLHERQQ
N
V
P
VFLL
G
DR
E
KA
L
AAM
DR
---
DL
L
E
-----
L
V
D
E
F
AWI
L
ED
T
A
DF
IA
G
R
AV
A
A
M
T
R
Y
RQQ
L
LPPL
FS
AL
M
KY
S
D
I
H
E
Y
SWAA
PGH
Q
GG
VG
F
T
K
T
P
A
G
R
FYH
D
YY
G
E
N
L
F
R
T
D
M
G
I
ER
T
S
LGSLLDHTG
AF
G
E
S
E
K
Y
A
ARVFGADRS
W
S
V
VV
GTS
G
SN
RTIMQA
C
MT
D
NDV
V
VV
DRNCHKS
I
E
QG
LM
L
T
GA
K
PVY
MV
P
S
RN
R
YGI
I
G
P
I
Y
PQ
E
M
Q
PE
T
L
Q
KK
I
S
E
S
P
LTKDK
A
G
Q
K
P
SYC
V
V
TN
C
TYDG
VC
YN
AK
E
AQ
D
L
L
EK
T
S
DRL
HFD
E
AW
YG
Y
A
R
F
N
PIY
A
DH
Y
A
M
R
GE
--
PGDH
N
G
PTV
F
A
T
H
STHKLL
N
ALSQAS
Y
IHV
REG
-
R
G
AI
N
FS
R
FN
Q
AYMMH
A
TTSP
L
Y
A
I
C
AS
N
DV
A
VS
MM
D
GN
S
G
LS
L
TQ
E
V
I
DE
A
V
D
FR
QA
M
A
---
RL
Y
K
E
FTADGS
WFF
K
P
W
NK
EV
V
T
D
PQTGKTYDFADAPTKLLTTV
Q
D
CW
V
M
H
PGE
S
WHGF
--
KDI
P
D
N
WS
M
LDPIKV
S
IL
A
PGM
G
EDG
E
LE
E
T
G
V
PAALV
TA
W
L
GR
HGIV
PTR
T
TDFQIM
FLFS
M
G
VTRG
K
W
GT
L
VN
T
L
C
S
FKR
H
YD
A
N
TP
L
AQVM
P
E
L
V
E
QY
PD
T
Y
A
NM
G
I
H
DL
GD
T
MFAWL
KE
N
N
PG
A
RL
N
E
A
Y
SG
LP
M
A
E
I
TP
RE
A
Y
N
AI
V
D
N
N
VE
L
V
S
I
E
N
L
P
GRI
A
AN
SVI
PYPPG
I
P
M
L
LS
GE
N
F
G
D
KNS
P
QV
S
Y
L
R
S
L
Q
S
W
D
H
H
F
PGFE
HETE
G
T
EI-I
DG
I
Y
H
V
M
CV
K
fig|679207.4.peg.3005
Escherichia coli MS 107-1 (22-755/756)
V
E
R
L
AD
AL
SQ
QN
VTV
I
K
S
T
S
F
DD
GFA
I
LS
S
N
E
A
I
DCLM
F
SYQ
M
E
H
P
D
EH
Q
N
V
R
QL
IGKLHERQQ
N
V
P
VFLL
G
DR
E
KA
L
AAM
DR
---
DL
L
E
-----
L
V
D
E
F
AWI
L
ED
T
A
DF
IA
G
R
AV
A
A
M
T
R
Y
RQQ
L
LPPL
FS
AL
M
KY
S
D
I
H
E
Y
SWAA
PGH
Q
GG
VG
F
T
K
T
P
A
G
R
FYH
D
YY
G
E
N
L
F
R
T
D
M
G
I
ER
T
S
LGSLLDHTG
AF
G
E
S
E
K
Y
A
ARVFGADRS
W
S
V
VV
GTS
G
SN
RTIMQA
C
MT
D
NDV
V
VV
DRNCHKS
I
E
QG
LM
L
T
GA
K
PVY
MV
P
S
RN
R
YGI
I
G
P
I
Y
PQ
E
M
Q
PE
T
L
Q
KK
I
S
E
S
P
LTKDK
A
G
Q
K
P
SYC
V
V
TN
C
TYDG
VC
YN
AK
E
AQ
D
L
L
EK
T
S
DRL
HFD
E
AW
YG
Y
A
R
F
N
PIY
A
DH
Y
A
M
R
GE
--
PGDH
N
G
PTV
F
A
T
H
STHKLL
N
ALSQAS
Y
IHV
REG
-
R
G
AI
N
FS
R
FN
Q
AYMMH
A
TTSP
L
Y
A
I
C
AS
N
DV
A
VS
MM
D
GN
S
G
LS
L
TQ
E
V
I
DE
A
V
D
FR
QA
M
A
---
RL
Y
K
E
FTADGS
WFF
K
P
W
NK
EV
V
T
D
PQTGKTYDFADAPTKLLTTV
Q
D
CW
V
M
H
PGE
S
WHGF
--
KDI
P
D
N
WS
M
LDPIKV
S
IL
A
PGM
G
EDG
E
LE
E
T
G
V
PAALV
TA
W
L
GR
HGIV
PTR
T
TDFQIM
FLFS
M
G
VTRG
K
W
GT
L
VN
T
L
C
S
FKR
H
YD
A
N
TP
L
AQVM
P
E
L
V
E
QY
PD
T
Y
A
NM
G
I
H
DL
GD
T
MFAWL
KE
N
N
PG
A
RL
N
E
A
Y
SG
LP
M
A
E
I
TP
RE
A
Y
N
AI
V
D
N
N
VE
L
V
S
I
E
N
L
P
GRI
A
AN
SVI
PYPPG
I
P
M
L
LS
GE
N
F
G
D
KNS
P
QV
S
Y
L
R
S
L
Q
S
W
D
H
H
F
PGFE
HETE
G
T
EI-I
DG
I
Y
H
V
M
CV
K
fig|679206.4.peg.977
Escherichia coli MS 119-7 (22-755/756)
V
E
R
L
AD
AL
SQ
QN
VTV
I
K
S
T
S
F
DD
GFA
I
LS
S
N
E
A
I
DCLM
F
SYQ
M
E
H
P
D
EH
Q
N
V
R
QL
IGKLHERQQ
N
V
P
VFLL
G
DR
E
KA
L
AAM
DR
---
DL
L
E
-----
L
V
D
E
F
AWI
L
ED
T
A
DF
IA
G
R
AV
A
A
M
T
R
Y
RQQ
L
LPPL
FS
AL
M
KY
S
D
I
H
E
Y
SWAA
PGH
Q
GG
VG
F
T
K
T
P
A
G
R
FYH
D
YY
G
E
N
L
F
R
T
D
M
G
I
ER
T
S
LGSLLDHTG
AF
G
E
S
E
K
Y
A
ARVFGADRS
W
S
V
VV
GTS
G
SN
RTIMQA
C
MT
D
NDV
V
VV
DRNCHKS
I
E
QG
LM
L
T
GA
K
PVY
MV
P
S
RN
R
YGI
I
G
P
I
Y
PQ
E
M
Q
PE
T
L
Q
KK
I
S
E
S
P
LTKDK
A
G
Q
K
P
SYC
V
V
TN
C
TYDG
VC
YN
AK
E
AQ
D
L
L
EK
T
S
DRL
HFD
E
AW
YG
Y
A
R
F
N
PIY
A
DH
Y
A
M
R
GE
--
PGDH
N
G
PTV
F
A
T
H
STHKLL
N
ALSQAS
Y
IHV
REG
-
R
G
AI
N
FS
R
FN
Q
AYMMH
A
TTSP
L
Y
A
I
C
AS
N
DV
A
VS
MM
D
GN
S
G
LS
L
TQ
E
V
I
DE
A
V
D
FR
QA
M
A
---
RL
Y
K
E
FTADGS
WFF
K
P
W
NK
EV
V
T
D
PQTGKTYDFADAPTKLLTTV
Q
D
CW
V
M
H
PGE
S
WHGF
--
KDI
P
D
N
WS
M
LDPIKV
S
IL
A
PGM
G
EDG
E
LE
E
T
G
V
PAALV
TA
W
L
GR
HGIV
PTR
T
TDFQIM
FLFS
M
G
VTRG
K
W
GT
L
VN
T
L
C
S
FKR
H
YD
A
N
TP
L
AQVM
P
E
L
V
E
QY
PD
T
Y
A
NM
G
I
H
DL
GD
T
MFAWL
KE
N
N
PG
A
RL
N
E
A
Y
SG
LP
M
A
E
I
TP
RE
A
Y
N
AI
V
D
N
N
VE
L
V
S
I
E
N
L
P
GRI
A
AN
SVI
PYPPG
I
P
M
L
LS
GE
N
F
G
D
KNS
P
QV
S
Y
L
R
S
L
Q
S
W
D
H
H
F
PGFE
HETE
G
T
EI-I
DG
I
Y
H
V
M
CV
K
fig|679204.3.peg.3962
Escherichia coli MS 145-7 (22-755/756)
V
E
R
L
AD
AL
SQ
QN
VTV
I
K
S
T
S
F
DD
GFA
I
LS
S
N
E
A
I
DCLM
F
SYQ
M
E
H
P
D
EH
Q
N
V
R
QL
IGKLHERQQ
N
V
P
VFLL
G
DR
E
KA
L
AAM
DR
---
DL
L
E
-----
L
V
D
E
F
AWI
L
ED
T
A
DF
IA
G
R
AV
A
A
M
T
R
Y
RQQ
L
LPPL
FS
AL
M
KY
S
D
I
H
E
Y
SWAA
PGH
Q
GG
VG
F
T
K
T
P
A
G
R
FYH
D
YY
G
E
N
L
F
R
T
D
M
G
I
ER
T
S
LGSLLDHTG
AF
G
E
S
E
K
Y
A
ARVFGADRS
W
S
V
VV
GTS
G
SN
RTIMQA
C
MT
D
NDV
V
VV
DRNCHKS
I
E
QG
LM
L
T
GA
K
PVY
MV
P
S
RN
R
YGI
I
G
P
I
Y
PQ
E
M
Q
PE
T
L
Q
KK
I
S
E
S
P
LTKDK
A
G
Q
K
P
SYC
V
V
TN
C
TYDG
VC
YN
AK
E
AQ
D
L
L
EK
T
S
DRL
HFD
E
AW
YG
Y
A
R
F
N
PIY
A
DH
Y
A
M
R
GE
--
PGDH
N
G
PTV
F
A
T
H
STHKLL
N
ALSQAS
Y
IHV
REG
-
R
G
AI
N
FS
R
FN
Q
AYMMH
A
TTSP
L
Y
A
I
C
AS
N
DV
A
VS
MM
D
GN
S
G
LS
L
TQ
E
V
I
DE
A
V
D
FR
QA
M
A
---
RL
Y
K
E
FTADGS
WFF
K
P
W
NK
EV
V
T
D
PQTGKTYDFADAPTKLLTTV
Q
D
CW
V
M
H
PGE
S
WHGF
--
KDI
P
D
N
WS
M
LDPIKV
S
IL
A
PGM
G
EDG
E
LE
E
T
G
V
PAALV
TA
W
L
GR
HGIV
PTR
T
TDFQIM
FLFS
M
G
VTRG
K
W
GT
L
VN
T
L
C
S
FKR
H
YD
A
N
TP
L
AQVM
P
E
L
V
E
QY
PD
T
Y
A
NM
G
I
H
DL
GD
T
MFAWL
KE
N
N
PG
A
RL
N
E
A
Y
SG
LP
M
A
E
I
TP
RE
A
Y
N
AI
V
D
N
N
VE
L
V
S
I
E
N
L
P
GRI
A
AN
SVI
PYPPG
I
P
M
L
LS
GE
N
F
G
D
KNS
P
QV
S
Y
L
R
S
L
Q
S
W
D
H
H
F
PGFE
HETE
G
T
EI-I
DG
I
Y
H
V
M
CV
K
fig|749532.3.peg.4578
Escherichia coli MS 78-1 (22-755/756)
V
E
R
L
AD
AL
SQ
QN
VTV
I
K
S
T
S
F
DD
GFA
I
LS
S
N
E
A
I
DCLM
F
SYQ
M
E
H
P
D
EH
Q
N
V
R
QL
IGKLHERQQ
N
V
P
VFLL
G
DR
E
KA
L
AAM
DR
---
DL
L
E
-----
L
V
D
E
F
AWI
L
ED
T
A
DF
IA
G
R
AV
A
A
M
T
R
Y
RQQ
L
LPPL
FS
AL
M
KY
S
D
I
H
E
Y
SWAA
PGH
Q
GG
VG
F
T
K
T
P
A
G
R
FYH
D
YY
G
E
N
L
F
R
T
D
M
G
I
ER
T
S
LGSLLDHTG
AF
G
E
S
E
K
Y
A
ARVFGADRS
W
S
V
VV
GTS
G
SN
RTIMQA
C
MT
D
NDV
V
VV
DRNCHKS
I
E
QG
LM
L
T
GA
K
PVY
MV
P
S
RN
R
YGI
I
G
P
I
Y
PQ
E
M
Q
PE
T
L
Q
KK
I
S
E
S
P
LTKDK
A
G
Q
K
P
SYC
V
V
TN
C
TYDG
VC
YN
AK
E
AQ
D
L
L
EK
T
S
DRL
HFD
E
AW
YG
Y
A
R
F
N
PIY
A
DH
Y
A
M
R
GE
--
PGDH
N
G
PTV
F
A
T
H
STHKLL
N
ALSQAS
Y
IHV
REG
-
R
G
AI
N
FS
R
FN
Q
AYMMH
A
TTSP
L
Y
A
I
C
AS
N
DV
A
VS
MM
D
GN
S
G
LS
L
TQ
E
V
I
DE
A
V
D
FR
QA
M
A
---
RL
Y
K
E
FTADGS
WFF
K
P
W
NK
EV
V
T
D
PQTGKTYDFADAPTKLLTTV
Q
D
CW
V
M
H
PGE
S
WHGF
--
KDI
P
D
N
WS
M
LDPIKV
S
IL
A
PGM
G
EDG
E
LE
E
T
G
V
PAALV
TA
W
L
GR
HGIV
PTR
T
TDFQIM
FLFS
M
G
VTRG
K
W
GT
L
VN
T
L
C
S
FKR
H
YD
A
N
TP
L
AQVM
P
E
L
V
E
QY
PD
T
Y
A
NM
G
I
H
DL
GD
T
MFAWL
KE
N
N
PG
A
RL
N
E
A
Y
SG
LP
M
A
E
I
TP
RE
A
Y
N
AI
V
D
N
N
VE
L
V
S
I
E
N
L
P
GRI
A
AN
SVI
PYPPG
I
P
M
L
LS
GE
N
F
G
D
KNS
P
QV
S
Y
L
R
S
L
Q
S
W
D
H
H
F
PGFE
HETE
G
T
EI-I
DG
I
Y
H
V
M
CV
K
fig|585396.4.peg.5192
Escherichia coli O111:H- str. 11128 (22-755/756)
V
E
R
L
AD
AL
SQ
QN
VTV
I
K
S
T
S
F
DD
GFA
I
LS
S
N
E
A
I
DCLM
F
SYQ
M
E
H
P
D
EH
Q
N
V
R
QL
IGKLHERQQ
N
V
P
VFLL
G
DR
E
KA
L
AAM
DR
---
DL
L
E
-----
L
V
D
E
F
AWI
L
ED
T
A
DF
IA
G
R
AV
A
A
M
T
R
Y
RQQ
L
LPPL
FS
AL
M
KY
S
D
I
H
E
Y
SWAA
PGH
Q
GG
VG
F
T
K
T
P
A
G
R
FYH
D
YY
G
E
N
L
F
R
T
D
M
G
I
ER
T
S
LGSLLDHTG
AF
G
E
S
E
K
Y
A
ARVFGADRS
W
S
V
VV
GTS
G
SN
RTIMQA
C
MT
D
NDV
V
VV
DRNCHKS
I
E
QG
LM
L
T
GA
K
PVY
MV
P
S
RN
R
YGI
I
G
P
I
Y
PQ
E
M
Q
PE
T
L
Q
KK
I
S
E
S
P
LTKDK
A
G
Q
K
P
SYC
V
V
TN
C
TYDG
VC
YN
AK
E
AQ
D
L
L
EK
T
S
DRL
HFD
E
AW
YG
Y
A
R
F
N
PIY
A
DH
Y
A
M
R
GE
--
PGDH
N
G
PTV
F
A
T
H
STHKLL
N
ALSQAS
Y
IHV
REG
-
R
G
AI
N
FS
R
FN
Q
AYMMH
A
TTSP
L
Y
A
I
C
AS
N
DV
A
VS
MM
D
GN
S
G
LS
L
TQ
E
V
I
DE
A
V
D
FR
QA
M
A
---
RL
Y
K
E
FTADGS
WFF
K
P
W
NK
EV
V
T
D
PQTGKTYDFADAPTKLLTTV
Q
D
CW
V
M
H
PGE
S
WHGF
--
KDI
P
D
N
WS
M
LDPIKV
S
IL
A
PGM
G
EDG
E
LE
E
T
G
V
PAALV
TA
W
L
GR
HGIV
PTR
T
TDFQIM
FLFS
M
G
VTRG
K
W
GT
L
VN
T
L
C
S
FKR
H
YD
A
N
TP
L
AQVM
P
E
L
V
E
QY
PD
T
Y
A
NM
G
I
H
DL
GD
T
MFAWL
KE
N
N
PG
A
RL
N
E
A
Y
SG
LP
M
A
E
I
TP
RE
A
Y
N
AI
V
D
N
N
VE
L
V
S
I
E
N
L
P
GRI
A
AN
SVI
PYPPG
I
P
M
L
LS
GE
N
F
G
D
KNS
P
QV
S
Y
L
R
S
L
Q
S
W
D
H
H
F
PGFE
HETE
G
T
EI-I
DG
I
Y
H
V
M
CV
K
fig|573235.3.peg.5399
Escherichia coli O26:H11 str. 11368 (22-755/756)
V
E
R
L
AD
AL
SQ
QN
VTV
I
K
S
T
S
F
DD
GFA
I
LS
S
N
E
A
I
DCLM
F
SYQ
M
E
H
P
D
EH
Q
N
V
R
QL
IGKLHERQQ
N
V
P
VFLL
G
DR
E
KA
L
AAM
DR
---
DL
L
E
-----
L
V
D
E
F
AWI
L
ED
T
A
DF
IA
G
R
AV
A
A
M
T
R
Y
RQQ
L
LPPL
FS
AL
M
KY
S
D
I
H
E
Y
SWAA
PGH
Q
GG
VG
F
T
K
T
P
A
G
R
FYH
D
YY
G
E
N
L
F
R
T
D
M
G
I
ER
T
S
LGSLLDHTG
AF
G
E
S
E
K
Y
A
ARVFGADRS
W
S
V
VV
GTS
G
SN
RTIMQA
C
MT
D
NDV
V
VV
DRNCHKS
I
E
QG
LM
L
T
GA
K
PVY
MV
P
S
RN
R
YGI
I
G
P
I
Y
PQ
E
M
Q
PE
T
L
Q
KK
I
S
E
S
P
LTKDK
A
G
Q
K
P
SYC
V
V
TN
C
TYDG
VC
YN
AK
E
AQ
D
L
L
EK
T
S
DRL
HFD
E
AW
YG
Y
A
R
F
N
PIY
A
DH
Y
A
M
R
GE
--
PGDH
N
G
PTV
F
A
T
H
STHKLL
N
ALSQAS
Y
IHV
REG
-
R
G
AI
N
FS
R
FN
Q
AYMMH
A
TTSP
L
Y
A
I
C
AS
N
DV
A
VS
MM
D
GN
S
G
LS
L
TQ
E
V
I
DE
A
V
D
FR
QA
M
A
---
RL
Y
K
E
FTADGS
WFF
K
P
W
NK
EV
V
T
D
PQTGKTYDFADAPTKLLTTV
Q
D
CW
V
M
H
PGE
S
WHGF
--
KDI
P
D
N
WS
M
LDPIKV
S
IL
A
PGM
G
EDG
E
LE
E
T
G
V
PAALV
TA
W
L
GR
HGIV
PTR
T
TDFQIM
FLFS
M
G
VTRG
K
W
GT
L
VN
T
L
C
S
FKR
H
YD
A
N
TP
L
AQVM
P
E
L
V
E
QY
PD
T
Y
A
NM
G
I
H
DL
GD
T
MFAWL
KE
N
N
PG
A
RL
N
E
A
Y
SG
LP
M
A
E
I
TP
RE
A
Y
N
AI
V
D
N
N
VE
L
V
S
I
E
N
L
P
GRI
A
AN
SVI
PYPPG
I
P
M
L
LS
GE
N
F
G
D
KNS
P
QV
S
Y
L
R
S
L
Q
S
W
D
H
H
F
PGFE
HETE
G
T
EI-I
DG
I
Y
H
V
M
CV
K
fig|409438.11.peg.4597
Escherichia coli SE11 (22-755/756)
V
E
R
L
AD
AL
SQ
QN
VTV
I
K
S
T
S
F
DD
GFA
I
LS
S
N
E
A
I
DCLM
F
SYQ
M
E
H
P
D
EH
Q
N
V
R
QL
IGKLHERQQ
N
V
P
VFLL
G
DR
E
KA
L
AAM
DR
---
DL
L
E
-----
L
V
D
E
F
AWI
L
ED
T
A
DF
IA
G
R
AV
A
A
M
T
R
Y
RQQ
L
LPPL
FS
AL
M
KY
S
D
I
H
E
Y
SWAA
PGH
Q
GG
VG
F
T
K
T
P
A
G
R
FYH
D
YY
G
E
N
L
F
R
T
D
M
G
I
ER
T
S
LGSLLDHTG
AF
G
E
S
E
K
Y
A
ARVFGADRS
W
S
V
VV
GTS
G
SN
RTIMQA
C
MT
D
NDV
V
VV
DRNCHKS
I
E
QG
LM
L
T
GA
K
PVY
MV
P
S
RN
R
YGI
I
G
P
I
Y
PQ
E
M
Q
PE
T
L
Q
KK
I
S
E
S
P
LTKDK
A
G
Q
K
P
SYC
V
V
TN
C
TYDG
VC
YN
AK
E
AQ
D
L
L
EK
T
S
DRL
HFD
E
AW
YG
Y
A
R
F
N
PIY
A
DH
Y
A
M
R
GE
--
PGDH
N
G
PTV
F
A
T
H
STHKLL
N
ALSQAS
Y
IHV
REG
-
R
G
AI
N
FS
R
FN
Q
AYMMH
A
TTSP
L
Y
A
I
C
AS
N
DV
A
VS
MM
D
GN
S
G
LS
L
TQ
E
V
I
DE
A
V
D
FR
QA
M
A
---
RL
Y
K
E
FTADGS
WFF
K
P
W
NK
EV
V
T
D
PQTGKTYDFADAPTKLLTTV
Q
D
CW
V
M
H
PGE
S
WHGF
--
KDI
P
D
N
WS
M
LDPIKV
S
IL
A
PGM
G
EDG
E
LE
E
T
G
V
PAALV
TA
W
L
GR
HGIV
PTR
T
TDFQIM
FLFS
M
G
VTRG
K
W
GT
L
VN
T
L
C
S
FKR
H
YD
A
N
TP
L
AQVM
P
E
L
V
E
QY
PD
T
Y
A
NM
G
I
H
DL
GD
T
MFAWL
KE
N
N
PG
A
RL
N
E
A
Y
SG
LP
M
A
E
I
TP
RE
A
Y
N
AI
V
D
N
N
VE
L
V
S
I
E
N
L
P
GRI
A
AN
SVI
PYPPG
I
P
M
L
LS
GE
N
F
G
D
KNS
P
QV
S
Y
L
R
S
L
Q
S
W
D
H
H
F
PGFE
HETE
G
T
EI-I
DG
I
Y
H
V
M
CV
K
fig|656443.3.peg.5103
Escherichia coli TA271 (22-755/756)
V
E
R
L
AD
AL
SQ
QN
VTV
I
K
S
T
S
F
DD
GFA
I
LS
S
N
E
A
I
DCLM
F
SYQ
M
E
H
P
D
EH
Q
N
V
R
QL
IGKLHERQQ
N
V
P
VFLL
G
DR
E
KA
L
AAM
DR
---
DL
L
E
-----
L
V
D
E
F
AWI
L
ED
T
A
DF
IA
G
R
AV
A
A
M
T
R
Y
RQQ
L
LPPL
FS
AL
M
KY
S
D
I
H
E
Y
SWAA
PGH
Q
GG
VG
F
T
K
T
P
A
G
R
FYH
D
YY
G
E
N
L
F
R
T
D
M
G
I
ER
T
S
LGSLLDHTG
AF
G
E
S
E
K
Y
A
ARVFGADRS
W
S
V
VV
GTS
G
SN
RTIMQA
C
MT
D
NDV
V
VV
DRNCHKS
I
E
QG
LM
L
T
GA
K
PVY
MV
P
S
RN
R
YGI
I
G
P
I
Y
PQ
E
M
Q
PE
T
L
Q
KK
I
S
E
S
P
LTKDK
A
G
Q
K
P
SYC
V
V
TN
C
TYDG
VC
YN
AK
E
AQ
D
L
L
EK
T
S
DRL
HFD
E
AW
YG
Y
A
R
F
N
PIY
A
DH
Y
A
M
R
GE
--
PGDH
N
G
PTV
F
A
T
H
STHKLL
N
ALSQAS
Y
IHV
REG
-
R
G
AI
N
FS
R
FN
Q
AYMMH
A
TTSP
L
Y
A
I
C
AS
N
DV
A
VS
MM
D
GN
S
G
LS
L
TQ
E
V
I
DE
A
V
D
FR
QA
M
A
---
RL
Y
K
E
FTADGS
WFF
K
P
W
NK
EV
V
T
D
PQTGKTYDFADAPTKLLTTV
Q
D
CW
V
M
H
PGE
S
WHGF
--
KDI
P
D
N
WS
M
LDPIKV
S
IL
A
PGM
G
EDG
E
LE
E
T
G
V
PAALV
TA
W
L
GR
HGIV
PTR
T
TDFQIM
FLFS
M
G
VTRG
K
W
GT
L
VN
T
L
C
S
FKR
H
YD
A
N
TP
L
AQVM
P
E
L
V
E
QY
PD
T
Y
A
NM
G
I
H
DL
GD
T
MFAWL
KE
N
N
PG
A
RL
N
E
A
Y
SG
LP
M
A
E
I
TP
RE
A
Y
N
AI
V
D
N
N
VE
L
V
S
I
E
N
L
P
GRI
A
AN
SVI
PYPPG
I
P
M
L
LS
GE
N
F
G
D
KNS
P
QV
S
Y
L
R
S
L
Q
S
W
D
H
H
F
PGFE
HETE
G
T
EI-I
DG
I
Y
H
V
M
CV
K
fig|566546.3.peg.2192
Escherichia coli W (22-755/756)
V
E
R
L
AD
AL
SQ
QN
VTV
I
K
S
T
S
F
DD
GFA
I
LS
S
N
E
A
I
DCLM
F
SYQ
M
E
H
P
D
EH
Q
N
V
R
QL
IGKLHERQQ
N
V
P
VFLL
G
DR
E
KA
L
AAM
DR
---
DL
L
E
-----
L
V
D
E
F
AWI
L
ED
T
A
DF
IA
G
R
AV
A
A
M
T
R
Y
RQQ
L
LPPL
FS
AL
M
KY
S
D
I
H
E
Y
SWAA
PGH
Q
GG
VG
F
T
K
T
P
A
G
R
FYH
D
YY
G
E
N
L
F
R
T
D
M
G
I
ER
T
S
LGSLLDHTG
AF
G
E
S
E
K
Y
A
ARVFGADRS
W
S
V
VV
GTS
G
SN
RTIMQA
C
MT
D
NDV
V
VV
DRNCHKS
I
E
QG
LM
L
T
GA
K
PVY
MV
P
S
RN
R
YGI
I
G
P
I
Y
PQ
E
M
Q
PE
T
L
Q
KK
I
S
E
S
P
LTKDK
A
G
Q
K
P
SYC
V
V
TN
C
TYDG
VC
YN
AK
E
AQ
D
L
L
EK
T
S
DRL
HFD
E
AW
YG
Y
A
R
F
N
PIY
A
DH
Y
A
M
R
GE
--
PGDH
N
G
PTV
F
A
T
H
STHKLL
N
ALSQAS
Y
IHV
REG
-
R
G
AI
N
FS
R
FN
Q
AYMMH
A
TTSP
L
Y
A
I
C
AS
N
DV
A
VS
MM
D
GN
S
G
LS
L
TQ
E
V
I
DE
A
V
D
FR
QA
M
A
---
RL
Y
K
E
FTADGS
WFF
K
P
W
NK
EV
V
T
D
PQTGKTYDFADAPTKLLTTV
Q
D
CW
V
M
H
PGE
S
WHGF
--
KDI
P
D
N
WS
M
LDPIKV
S
IL
A
PGM
G
EDG
E
LE
E
T
G
V
PAALV
TA
W
L
GR
HGIV
PTR
T
TDFQIM
FLFS
M
G
VTRG
K
W
GT
L
VN
T
L
C
S
FKR
H
YD
A
N
TP
L
AQVM
P
E
L
V
E
QY
PD
T
Y
A
NM
G
I
H
DL
GD
T
MFAWL
KE
N
N
PG
A
RL
N
E
A
Y
SG
LP
M
A
E
I
TP
RE
A
Y
N
AI
V
D
N
N
VE
L
V
S
I
E
N
L
P
GRI
A
AN
SVI
PYPPG
I
P
M
L
LS
GE
N
F
G
D
KNS
P
QV
S
Y
L
R
S
L
Q
S
W
D
H
H
F
PGFE
HETE
G
T
EI-I
DG
I
Y
H
V
M
CV
K
fig|566546.4.peg.4413
Escherichia coli W (22-755/756)
V
E
R
L
AD
AL
SQ
QN
VTV
I
K
S
T
S
F
DD
GFA
I
LS
S
N
E
A
I
DCLM
F
SYQ
M
E
H
P
D
EH
Q
N
V
R
QL
IGKLHERQQ
N
V
P
VFLL
G
DR
E
KA
L
AAM
DR
---
DL
L
E
-----
L
V
D
E
F
AWI
L
ED
T
A
DF
IA
G
R
AV
A
A
M
T
R
Y
RQQ
L
LPPL
FS
AL
M
KY
S
D
I
H
E
Y
SWAA
PGH
Q
GG
VG
F
T
K
T
P
A
G
R
FYH
D
YY
G
E
N
L
F
R
T
D
M
G
I
ER
T
S
LGSLLDHTG
AF
G
E
S
E
K
Y
A
ARVFGADRS
W
S
V
VV
GTS
G
SN
RTIMQA
C
MT
D
NDV
V
VV
DRNCHKS
I
E
QG
LM
L
T
GA
K
PVY
MV
P
S
RN
R
YGI
I
G
P
I
Y
PQ
E
M
Q
PE
T
L
Q
KK
I
S
E
S
P
LTKDK
A
G
Q
K
P
SYC
V
V
TN
C
TYDG
VC
YN
AK
E
AQ
D
L
L
EK
T
S
DRL
HFD
E
AW
YG
Y
A
R
F
N
PIY
A
DH
Y
A
M
R
GE
--
PGDH
N
G
PTV
F
A
T
H
STHKLL
N
ALSQAS
Y
IHV
REG
-
R
G
AI
N
FS
R
FN
Q
AYMMH
A
TTSP
L
Y
A
I
C
AS
N
DV
A
VS
MM
D
GN
S
G
LS
L
TQ
E
V
I
DE
A
V
D
FR
QA
M
A
---
RL
Y
K
E
FTADGS
WFF
K
P
W
NK
EV
V
T
D
PQTGKTYDFADAPTKLLTTV
Q
D
CW
V
M
H
PGE
S
WHGF
--
KDI
P
D
N
WS
M
LDPIKV
S
IL
A
PGM
G
EDG
E
LE
E
T
G
V
PAALV
TA
W
L
GR
HGIV
PTR
T
TDFQIM
FLFS
M
G
VTRG
K
W
GT
L
VN
T
L
C
S
FKR
H
YD
A
N
TP
L
AQVM
P
E
L
V
E
QY
PD
T
Y
A
NM
G
I
H
DL
GD
T
MFAWL
KE
N
N
PG
A
RL
N
E
A
Y
SG
LP
M
A
E
I
TP
RE
A
Y
N
AI
V
D
N
N
VE
L
V
S
I
E
N
L
P
GRI
A
AN
SVI
PYPPG
I
P
M
L
LS
GE
N
F
G
D
KNS
P
QV
S
Y
L
R
S
L
Q
S
W
D
H
H
F
PGFE
HETE
G
T
EI-I
DG
I
Y
H
V
M
CV
K
fig|562.371.peg.3635
Escherichia coli 1044A (22-755/756)
V
E
R
L
AD
AL
SQ
QN
VTV
I
K
S
T
S
F
DD
GFA
I
LS
S
N
E
A
I
DCLM
F
SYQ
M
E
H
P
D
EH
Q
N
V
R
QL
IGKLHERQQ
N
V
P
VFLL
G
DR
E
KA
L
AAM
DR
---
DL
L
E
-----
L
V
D
E
F
AWI
L
ED
T
A
DF
IA
G
R
AV
A
A
M
T
R
Y
RQQ
L
LPPL
FS
AL
M
KY
S
D
I
H
E
Y
SWAA
PGH
Q
GG
VG
F
T
K
T
P
A
G
R
FYH
D
YY
G
E
N
L
F
R
T
D
M
G
I
ER
T
S
LGSLLDHTG
AF
G
E
S
E
K
Y
A
ARVFGADRS
W
S
V
VV
GTS
G
SN
RTIMQA
C
MT
D
NDV
V
VV
DRNCHKS
I
E
QG
LM
L
T
GA
K
PVY
MV
P
S
RN
R
YGI
I
G
P
I
Y
PQ
E
M
Q
PE
T
L
Q
KK
I
S
E
S
P
LTKDK
A
G
Q
K
P
SYC
V
V
TN
C
TYDG
VC
YN
AK
E
AQ
D
L
L
EK
T
S
DRL
HFD
E
AW
YG
Y
A
R
F
N
PIY
A
DH
Y
A
M
R
GE
--
PGDH
N
G
PTV
F
A
T
H
STHKLL
N
ALSQAS
Y
IHV
REG
-
R
G
AI
N
FS
R
FN
Q
AYMMH
A
TTSP
L
Y
A
I
C
AS
N
DV
A
VS
MM
D
GN
S
G
LS
L
TQ
E
V
I
DE
A
V
D
FR
QA
M
A
---
RL
Y
K
E
F
A
ADGS
WFF
K
P
W
NK
EV
V
T
D
PQTGKTYDFADAPTKLLTTV
Q
D
CW
V
M
H
PGE
S
WHGF
--
KDI
P
D
N
WS
M
LDPIKV
S
IL
A
PGM
G
EDG
E
LE
E
T
G
V
PAALV
TA
W
L
GR
HGIV
PTR
T
TDFQIM
FLFS
M
G
VTRG
K
W
GT
L
VN
T
L
C
S
FKR
H
YD
A
N
TP
L
AQVM
P
E
L
V
E
QY
PD
T
Y
A
NM
G
I
H
DL
GD
T
MFAWL
KE
N
N
PG
A
RL
N
E
A
Y
SG
LP
V
A
E
I
TP
RE
A
Y
N
AI
V
D
N
N
VE
L
V
S
I
E
N
L
P
GRI
A
AN
SVI
PYPPG
I
P
M
L
LS
GE
N
F
G
D
KNS
P
QV
S
Y
L
R
S
L
Q
S
W
D
H
H
F
PGFE
HETE
G
T
EI-I
DG
I
Y
H
V
M
CV
K
fig|562.373.peg.5768
Escherichia coli 1125A (22-755/756)
V
E
R
L
AD
AL
SQ
QN
VTV
I
K
S
T
S
F
DD
GFA
I
LS
S
N
E
A
I
DCLM
F
SYQ
M
E
H
P
D
EH
Q
N
V
R
QL
IGKLHERQQ
N
V
P
VFLL
G
DR
E
KA
L
AAM
DR
---
DL
L
E
-----
L
V
D
E
F
AWI
L
ED
T
A
DF
IA
G
R
AV
A
A
M
T
R
Y
RQQ
L
LPPL
FS
AL
M
KY
S
D
I
H
E
Y
SWAA
PGH
Q
GG
VG
F
T
K
T
P
A
G
R
FYH
D
YY
G
E
N
L
F
R
T
D
M
G
I
ER
T
S
LGSLLDHTG
AF
G
E
S
E
K
Y
A
ARVFGADRS
W
S
V
VV
GTS
G
SN
RTIMQA
C
MT
D
NDV
V
VV
DRNCHKS
I
E
QG
LM
L
T
GA
K
PVY
MV
P
S
RN
R
YGI
I
G
P
I
Y
PQ
E
M
Q
PE
T
L
Q
KK
I
S
E
S
P
LTKDK
A
G
Q
K
P
SYC
V
V
TN
C
TYDG
VC
YN
AK
E
AQ
D
L
L
EK
T
S
DRL
HFD
E
AW
YG
Y
A
R
F
N
PIY
A
DH
Y
A
M
R
GE
--
PGDH
N
G
PTV
F
A
T
H
STHKLL
N
ALSQAS
Y
IHV
REG
-
R
G
AI
N
FS
R
FN
Q
AYMMH
A
TTSP
L
Y
A
I
C
AS
N
DV
A
VS
MM
D
GN
S
G
LS
L
TQ
E
V
I
DE
A
V
D
FR
QA
M
A
---
RL
Y
K
E
F
A
ADGS
WFF
K
P
W
NK
EV
V
T
D
PQTGKTYDFADAPTKLLTTV
Q
D
CW
V
M
H
PGE
S
WHGF
--
KDI
P
D
N
WS
M
LDPIKV
S
IL
A
PGM
G
EDG
E
LE
E
T
G
V
PAALV
TA
W
L
GR
HGIV
PTR
T
TDFQIM
FLFS
M
G
VTRG
K
W
GT
L
VN
T
L
C
S
FKR
H
YD
A
N
TP
L
AQVM
P
E
L
V
E
QY
PD
T
Y
A
NM
G
I
H
DL
GD
T
MFAWL
KE
N
N
PG
A
RL
N
E
A
Y
SG
LP
V
A
E
I
TP
RE
A
Y
N
AI
V
D
N
N
VE
L
V
S
I
E
N
L
P
GRI
A
AN
SVI
PYPPG
I
P
M
L
LS
GE
N
F
G
D
KNS
P
QV
S
Y
L
R
S
L
Q
S
W
D
H
H
F
PGFE
HETE
G
T
EI-I
DG
I
Y
H
V
M
CV
K
fig|562.372.peg.3423
Escherichia coli 1212A (22-755/756)
V
E
R
L
AD
AL
SQ
QN
VTV
I
K
S
T
S
F
DD
GFA
I
LS
S
N
E
A
I
DCLM
F
SYQ
M
E
H
P
D
EH
Q
N
V
R
QL
IGKLHERQQ
N
V
P
VFLL
G
DR
E
KA
L
AAM
DR
---
DL
L
E
-----
L
V
D
E
F
AWI
L
ED
T
A
DF
IA
G
R
AV
A
A
M
T
R
Y
RQQ
L
LPPL
FS
AL
M
KY
S
D
I
H
E
Y
SWAA
PGH
Q
GG
VG
F
T
K
T
P
A
G
R
FYH
D
YY
G
E
N
L
F
R
T
D
M
G
I
ER
T
S
LGSLLDHTG
AF
G
E
S
E
K
Y
A
ARVFGADRS
W
S
V
VV
GTS
G
SN
RTIMQA
C
MT
D
NDV
V
VV
DRNCHKS
I
E
QG
LM
L
T
GA
K
PVY
MV
P
S
RN
R
YGI
I
G
P
I
Y
PQ
E
M
Q
PE
T
L
Q
KK
I
S
E
S
P
LTKDK
A
G
Q
K
P
SYC
V
V
TN
C
TYDG
VC
YN
AK
E
AQ
D
L
L
EK
T
S
DRL
HFD
E
AW
YG
Y
A
R
F
N
PIY
A
DH
Y
A
M
R
GE
--
PGDH
N
G
PTV
F
A
T
H
STHKLL
N
ALSQAS
Y
IHV
REG
-
R
G
AI
N
FS
R
FN
Q
AYMMH
A
TTSP
L
Y
A
I
C
AS
N
DV
A
VS
MM
D
GN
S
G
LS
L
TQ
E
V
I
DE
A
V
D
FR
QA
M
A
---
RL
Y
K
E
F
A
ADGS
WFF
K
P
W
NK
EV
V
T
D
PQTGKTYDFADAPTKLLTTV
Q
D
CW
V
M
H
PGE
S
WHGF
--
KDI
P
D
N
WS
M
LDPIKV
S
IL
A
PGM
G
EDG
E
LE
E
T
G
V
PAALV
TA
W
L
GR
HGIV
PTR
T
TDFQIM
FLFS
M
G
VTRG
K
W
GT
L
VN
T
L
C
S
FKR
H
YD
A
N
TP
L
AQVM
P
E
L
V
E
QY
PD
T
Y
A
NM
G
I
H
DL
GD
T
MFAWL
KE
N
N
PG
A
RL
N
E
A
Y
SG
LP
V
A
E
I
TP
RE
A
Y
N
AI
V
D
N
N
VE
L
V
S
I
E
N
L
P
GRI
A
AN
SVI
PYPPG
I
P
M
L
LS
GE
N
F
G
D
KNS
P
QV
S
Y
L
R
S
L
Q
S
W
D
H
H
F
PGFE
HETE
G
T
EI-I
DG
I
Y
H
V
M
CV
K
fig|562.374.peg.2758
Escherichia coli 536A (22-755/756)
V
E
R
L
AD
AL
SQ
QN
VTV
I
K
S
T
S
F
DD
GFA
I
LS
S
N
E
A
I
DCLM
F
SYQ
M
E
H
P
D
EH
Q
N
V
R
QL
IGKLHERQQ
N
V
P
VFLL
G
DR
E
KA
L
AAM
DR
---
DL
L
E
-----
L
V
D
E
F
AWI
L
ED
T
A
DF
IA
G
R
AV
A
A
M
T
R
Y
RQQ
L
LPPL
FS
AL
M
KY
S
D
I
H
E
Y
SWAA
PGH
Q
GG
VG
F
T
K
T
P
A
G
R
FYH
D
YY
G
E
N
L
F
R
T
D
M
G
I
ER
T
S
LGSLLDHTG
AF
G
E
S
E
K
Y
A
ARVFGADRS
W
S
V
VV
GTS
G
SN
RTIMQA
C
MT
D
NDV
V
VV
DRNCHKS
I
E
QG
LM
L
T
GA
K
PVY
MV
P
S
RN
R
YGI
I
G
P
I
Y
PQ
E
M
Q
PE
T
L
Q
KK
I
S
E
S
P
LTKDK
A
G
Q
K
P
SYC
V
V
TN
C
TYDG
VC
YN
AK
E
AQ
D
L
L
EK
T
S
DRL
HFD
E
AW
YG
Y
A
R
F
N
PIY
A
DH
Y
A
M
R
GE
--
PGDH
N
G
PTV
F
A
T
H
STHKLL
N
ALSQAS
Y
IHV
REG
-
R
G
AI
N
FS
R
FN
Q
AYMMH
A
TTSP
L
Y
A
I
C
AS
N
DV
A
VS
MM
D
GN
S
G
LS
L
TQ
E
V
I
DE
A
V
D
FR
QA
M
A
---
RL
Y
K
E
F
A
ADGS
WFF
K
P
W
NK
EV
V
T
D
PQTGKTYDFADAPTKLLTTV
Q
D
CW
V
M
H
PGE
S
WHGF
--
KDI
P
D
N
WS
M
LDPIKV
S
IL
A
PGM
G
EDG
E
LE
E
T
G
V
PAALV
TA
W
L
GR
HGIV
PTR
T
TDFQIM
FLFS
M
G
VTRG
K
W
GT
L
VN
T
L
C
S
FKR
H
YD
A
N
TP
L
AQVM
P
E
L
V
E
QY
PD
T
Y
A
NM
G
I
H
DL
GD
T
MFAWL
KE
N
N
PG
A
RL
N
E
A
Y
SG
LP
V
A
E
I
TP
RE
A
Y
N
AI
V
D
N
N
VE
L
V
S
I
E
N
L
P
GRI
A
AN
SVI
PYPPG
I
P
M
L
LS
GE
N
F
G
D
KNS
P
QV
S
Y
L
R
S
L
Q
S
W
D
H
H
F
PGFE
HETE
G
T
EI-I
DG
I
Y
H
V
M
CV
K
fig|550676.3.peg.4392
Escherichia coli B185 (22-755/756)
V
E
R
L
AD
AL
SQ
QN
VTV
I
K
S
T
S
F
DD
GFA
I
LS
S
N
E
A
I
DCLM
F
SYQ
M
E
H
P
D
EH
Q
N
V
R
QL
IGKLHERQQ
N
V
P
VFLL
G
DR
E
KA
L
AAM
DR
---
DL
L
E
-----
L
V
D
E
F
AWI
L
ED
T
A
DF
IA
G
R
AV
A
A
M
T
R
Y
RQQ
L
LPPL
FS
AL
M
KY
S
D
I
H
E
Y
SWAA
PGH
Q
GG
VG
F
T
K
T
P
A
G
R
FYH
D
YY
G
E
N
L
F
R
T
D
M
G
I
ER
T
S
LGSLLDHTG
AF
G
E
S
E
K
Y
A
ARVFGADRS
W
S
V
VV
GTS
G
SN
RTIMQA
C
MT
D
NDV
V
VV
DRNCHKS
I
E
QG
LM
L
T
GA
K
PVY
MV
P
S
RN
R
YGI
I
G
P
I
Y
PQ
E
M
Q
PE
T
L
Q
KK
I
S
E
S
P
LTKDK
A
G
Q
K
P
SYC
V
V
TN
C
TYDG
VC
YN
AK
E
AQ
D
L
L
EK
T
S
DRL
HFD
E
AW
YG
Y
A
R
F
N
PIY
A
DH
Y
A
M
R
GE
--
PGDH
N
G
PTV
F
A
T
H
STHKLL
N
ALSQAS
Y
IHV
REG
-
R
G
AI
N
FS
R
FN
Q
AYMMH
A
TTSP
L
Y
A
I
C
AS
N
DV
A
VS
MM
D
GN
S
G
LS
L
TQ
E
V
I
DE
A
V
D
FR
QA
M
A
---
RL
Y
K
E
FTADGS
WFF
K
P
W
NK
EV
V
T
D
PQTGKTYDFADAPTKLLTTV
Q
D
CW
V
M
H
PGE
S
WHGF
--
KDI
P
D
N
WS
M
LDPIKV
S
IL
A
PGM
G
EDG
E
LE
E
T
G
V
PAALV
TA
W
L
GR
HGIV
PTR
T
TDFQIM
FLFS
M
G
VTRG
K
W
GT
L
VN
T
L
C
S
FKR
H
YD
A
N
TP
L
AQVM
P
E
L
V
E
QY
PD
T
Y
A
NM
G
I
H
DL
GD
T
MFAWL
KE
N
N
PG
A
RL
N
E
A
Y
SG
LP
V
A
E
I
TP
RE
A
Y
N
AI
V
D
N
N
VE
L
V
S
I
E
N
L
P
GRI
A
AN
SVI
PYPPG
I
P
M
L
LS
GE
N
F
G
D
KNS
P
QV
S
Y
L
R
S
L
Q
S
W
D
H
H
F
PGFE
HETE
G
T
EI-I
DG
I
Y
H
V
M
CV
K
fig|550677.3.peg.113
Escherichia coli B354 (22-755/756)
V
E
R
L
AD
AL
SQ
QN
VTV
I
K
S
T
S
F
DD
GFA
I
LS
S
N
E
A
I
DCLM
F
SYQ
M
E
H
P
D
EH
Q
N
V
R
QL
IGKLHERQQ
N
V
P
VFLL
G
DR
E
KA
L
AAM
DR
---
DL
L
E
-----
L
V
D
E
F
AWI
L
ED
T
A
DF
IA
G
R
AV
A
A
M
T
R
Y
RQQ
L
LPPL
FS
AL
M
KY
S
D
I
H
E
Y
SWAA
PGH
Q
GG
VG
F
T
K
T
P
A
G
R
FYH
D
YY
G
E
N
L
F
R
T
D
M
G
I
ER
T
S
LGSLLDHTG
AF
G
E
S
E
K
Y
A
ARVFGADRS
W
S
V
VV
GTS
G
SN
RTIMQA
C
MT
D
NDV
V
VV
DRNCHKS
I
E
QG
LM
L
T
GA
K
PVY
MV
P
S
RN
R
YGI
I
G
P
I
Y
PQ
E
M
Q
PE
T
L
Q
KK
I
S
E
S
P
LTKDK
A
G
Q
K
P
SYC
V
V
TN
C
TYDG
VC
YN
AK
E
AQ
D
L
L
EK
T
S
DRL
HFD
E
AW
YG
Y
A
R
F
N
PIY
A
DH
Y
A
M
R
GE
--
PGDH
N
G
PTV
F
A
T
H
STHKLL
N
ALSQAS
Y
IHV
REG
-
R
G
AI
N
FS
R
FN
Q
AYMMH
A
TTSP
L
Y
A
I
C
AS
N
DV
A
VS
MM
D
GN
S
G
LS
L
TQ
E
V
I
DE
A
V
D
FR
QA
M
A
---
RL
Y
K
E
FTADGS
WFF
K
P
W
NK
EV
V
T
D
PQTGKTYDFADAPTKLLTTV
Q
D
CW
V
M
H
PGE
S
WHGF
--
KDI
P
D
N
WS
M
LDPIKV
S
IL
A
PGM
G
EDG
E
LE
E
T
G
V
PAALV
TA
W
L
GR
HGIV
PTR
T
TDFQIM
FLFS
M
G
VTRG
K
W
GT
L
VN
T
L
C
S
FKR
H
YD
A
N
TP
L
AQVM
P
E
L
V
E
QY
PD
T
Y
A
NM
G
I
H
DL
GD
T
MFAWL
KE
N
N
PG
A
RL
N
E
A
Y
SG
LP
V
A
E
I
TP
RE
A
Y
N
AI
V
D
N
N
VE
L
V
S
I
E
N
L
P
GRI
A
AN
SVI
PYPPG
I
P
M
L
LS
GE
N
F
G
D
KNS
P
QV
S
Y
L
R
S
L
Q
S
W
D
H
H
F
PGFE
HETE
G
T
EI-I
DG
I
Y
H
V
M
CV
K
fig|656379.3.peg.490
Escherichia coli FVEC1302 (22-755/756)
V
E
R
L
AD
AL
SQ
QN
VTV
I
K
S
T
S
F
DD
GFA
I
LS
S
N
E
A
I
DCLM
F
SYQ
M
E
H
P
D
EH
Q
N
V
R
QL
IGKLHERQQ
N
V
P
VFLL
G
DR
E
KA
L
AAM
DR
---
DL
L
E
-----
L
V
D
E
F
AWI
L
ED
T
A
DF
IA
G
R
AV
A
A
M
T
R
Y
RQQ
L
LPPL
FS
AL
M
KY
S
D
I
H
E
Y
SWAA
PGH
Q
GG
VG
F
T
K
T
P
A
G
R
FYH
D
YY
G
E
N
L
F
R
T
D
M
G
I
ER
T
S
LGSLLDHTG
AF
G
E
S
E
K
Y
A
ARVFGADRS
W
S
V
VV
GTS
G
SN
RTIMQA
C
MT
D
NDV
V
VV
DRNCHKS
I
E
QG
LM
L
T
GA
K
PVY
MV
P
S
RN
R
YGI
I
G
P
I
Y
PQ
E
M
Q
PE
T
L
Q
KK
I
S
E
S
P
LTKDK
A
G
Q
K
P
SYC
V
V
TN
C
TYDG
VC
YN
AK
E
AQ
D
L
L
EK
T
S
DRL
HFD
E
AW
YG
Y
A
R
F
N
PIY
A
DH
Y
A
M
R
GE
--
PGDH
N
G
PTV
F
A
T
H
STHKLL
N
ALSQAS
Y
IHV
REG
-
R
G
AI
N
FS
R
FN
Q
AYMMH
A
TTSP
L
Y
A
I
C
AS
N
DV
A
VS
MM
D
GN
S
G
LS
L
TQ
E
V
I
DE
A
V
D
FR
QA
M
A
---
RL
Y
K
E
FTADGS
WFF
K
P
W
NK
EV
V
T
D
PQTGKTYDFADAPTKLLTTV
Q
D
CW
V
M
H
PGE
S
WHGF
--
KDI
P
D
N
WS
M
LDPIKV
S
IL
A
PGM
G
EDG
E
LE
E
T
G
V
PAALV
TA
W
L
GR
HGIV
PTR
T
TDFQIM
FLFS
M
G
VTRG
K
W
GT
L
VN
T
L
C
S
FKR
H
YD
A
N
TP
L
AQVM
P
E
L
V
E
QY
PD
T
Y
A
NM
G
I
H
DL
GD
T
MFAWL
KE
N
N
PG
A
RL
N
E
A
Y
SG
LP
V
A
E
I
TP
RE
A
Y
N
AI
V
D
N
N
VE
L
V
S
I
E
N
L
P
GRI
A
AN
SVI
PYPPG
I
P
M
L
LS
GE
N
F
G
D
KNS
P
QV
S
Y
L
R
S
L
Q
S
W
D
H
H
F
PGFE
HETE
G
T
EI-I
DG
I
Y
H
V
M
CV
K
fig|656380.3.peg.482
Escherichia coli FVEC1412 (22-755/756)
V
E
R
L
AD
AL
SQ
QN
VTV
I
K
S
T
S
F
DD
GFA
I
LS
S
N
E
A
I
DCLM
F
SYQ
M
E
H
P
D
EH
Q
N
V
R
QL
IGKLHERQQ
N
V
P
VFLL
G
DR
E
KA
L
AAM
DR
---
DL
L
E
-----
L
V
D
E
F
AWI
L
ED
T
A
DF
IA
G
R
AV
A
A
M
T
R
Y
RQQ
L
LPPL
FS
AL
M
KY
S
D
I
H
E
Y
SWAA
PGH
Q
GG
VG
F
T
K
T
P
A
G
R
FYH
D
YY
G
E
N
L
F
R
T
D
M
G
I
ER
T
S
LGSLLDHTG
AF
G
E
S
E
K
Y
A
ARVFGADRS
W
S
V
VV
GTS
G
SN
RTIMQA
C
MT
D
NDV
V
VV
DRNCHKS
I
E
QG
LM
L
T
GA
K
PVY
MV
P
S
RN
R
YGI
I
G
P
I
Y
PQ
E
M
Q
PE
T
L
Q
KK
I
S
E
S
P
LTKDK
A
G
Q
K
P
SYC
V
V
TN
C
TYDG
VC
YN
AK
E
AQ
D
L
L
EK
T
S
DRL
HFD
E
AW
YG
Y
A
R
F
N
PIY
A
DH
Y
A
M
R
GE
--
PGDH
N
G
PTV
F
A
T
H
STHKLL
N
ALSQAS
Y
IHV
REG
-
R
G
AI
N
FS
R
FN
Q
AYMMH
A
TTSP
L
Y
A
I
C
AS
N
DV
A
VS
MM
D
GN
S
G
LS
L
TQ
E
V
I
DE
A
V
D
FR
QA
M
A
---
RL
Y
K
E
FTADGS
WFF
K
P
W
NK
EV
V
T
D
PQTGKTYDFADAPTKLLTTV
Q
D
CW
V
M
H
PGE
S
WHGF
--
KDI
P
D
N
WS
M
LDPIKV
S
IL
A
PGM
G
EDG
E
LE
E
T
G
V
PAALV
TA
W
L
GR
HGIV
PTR
T
TDFQIM
FLFS
M
G
VTRG
K
W
GT
L
VN
T
L
C
S
FKR
H
YD
A
N
TP
L
AQVM
P
E
L
V
E
QY
PD
T
Y
A
NM
G
I
H
DL
GD
T
MFAWL
KE
N
N
PG
A
RL
N
E
A
Y
SG
LP
V
A
E
I
TP
RE
A
Y
N
AI
V
D
N
N
VE
L
V
S
I
E
N
L
P
GRI
A
AN
SVI
PYPPG
I
P
M
L
LS
GE
N
F
G
D
KNS
P
QV
S
Y
L
R
S
L
Q
S
W
D
H
H
F
PGFE
HETE
G
T
EI-I
DG
I
Y
H
V
M
CV
K
fig|749537.3.peg.4290
Escherichia coli MS 115-1 (22-755/756)
V
E
R
L
AD
AL
SQ
QN
VTV
I
K
S
T
S
F
DD
GFA
I
LS
S
N
E
A
I
DCLM
F
SYQ
M
E
H
P
D
EH
Q
N
V
R
QL
IGKLHERQQ
N
V
P
VFLL
G
DR
E
KA
L
AAM
DR
---
DL
L
E
-----
L
V
D
E
F
AWI
L
ED
T
A
DF
IA
G
R
AV
A
A
M
T
R
Y
RQQ
L
LPPL
FS
AL
M
KY
S
D
I
H
E
Y
SWAA
PGH
Q
GG
VG
F
T
K
T
P
A
G
R
FYH
D
YY
G
E
N
L
F
R
T
D
M
G
I
ER
T
S
LGSLLDHTG
AF
G
E
S
E
K
Y
A
ARVFGADRS
W
S
V
VV
GTS
G
SN
RTIMQA
C
MT
D
NDV
V
VV
DRNCHKS
I
E
QG
LM
L
T
GA
K
PVY
MV
P
S
RN
R
YGI
I
G
P
I
Y
PQ
E
M
Q
PE
T
L
Q
KK
I
S
E
S
P
LTKDK
A
G
Q
K
P
SYC
V
V
TN
C
TYDG
VC
YN
AK
E
AQ
D
L
L
EK
T
S
DRL
HFD
E
AW
YG
Y
A
R
F
N
PIY
A
DH
Y
A
M
R
GE
--
PGDH
N
G
PTV
F
A
T
H
STHKLL
N
ALSQAS
Y
IHV
REG
-
R
G
AI
N
FS
R
FN
Q
AYMMH
A
TTSP
L
Y
A
I
C
AS
N
DV
A
VS
MM
D
GN
S
G
LS
L
TQ
E
V
I
DE
A
V
D
FR
QA
M
A
---
RL
Y
K
E
FTADGS
WFF
K
P
W
NK
EV
V
T
D
PQTGKTYDFADAPTKLLTTV
Q
D
CW
V
M
H
PGE
S
WHGF
--
KDI
P
D
N
WS
M
LDPIKV
S
IL
A
PGM
G
EDG
E
LE
E
T
G
V
PAALV
TA
W
L
GR
HGIV
PTR
T
TDFQIM
FLFS
M
G
VTRG
K
W
GT
L
VN
T
L
C
S
FKR
H
YD
A
N
TP
L
AQVM
P
E
L
V
E
QY
PD
T
Y
A
NM
G
I
H
DL
GD
T
MFAWL
KE
N
N
PG
A
RL
N
E
A
Y
SG
LP
V
A
E
I
TP
RE
A
Y
N
AI
V
D
N
N
VE
L
V
S
I
E
N
L
P
GRI
A
AN
SVI
PYPPG
I
P
M
L
LS
GE
N
F
G
D
KNS
P
QV
S
Y
L
R
S
L
Q
S
W
D
H
H
F
PGFE
HETE
G
T
EI-I
DG
I
Y
H
V
M
CV
K
fig|749549.3.peg.1647
Escherichia coli MS 198-1 (22-755/756)
V
E
R
L
AD
AL
SQ
QN
VTV
I
K
S
T
S
F
DD
GFA
I
LS
S
N
E
A
I
DCLM
F
SYQ
M
E
H
P
D
EH
Q
N
V
R
QL
IGKLHERQQ
N
V
P
VFLL
G
DR
E
KA
L
AAM
DR
---
DL
L
E
-----
L
V
D
E
F
AWI
L
ED
T
A
DF
IA
G
R
AV
A
A
M
T
R
Y
RQQ
L
LPPL
FS
AL
M
KY
S
D
I
H
E
Y
SWAA
PGH
Q
GG
VG
F
T
K
T
P
A
G
R
FYH
D
YY
G
E
N
L
F
R
T
D
M
G
I
ER
T
S
LGSLLDHTG
AF
G
E
S
E
K
Y
A
ARVFGADRS
W
S
V
VV
GTS
G
SN
RTIMQA
C
MT
D
NDV
V
VV
DRNCHKS
I
E
QG
LM
L
T
GA
K
PVY
MV
P
S
RN
R
YGI
I
G
P
I
Y
PQ
E
M
Q
PE
T
L
Q
KK
I
S
E
S
P
LTKDK
A
G
Q
K
P
SYC
V
V
TN
C
TYDG
VC
YN
AK
E
AQ
D
L
L
EK
T
S
DRL
HFD
E
AW
YG
Y
A
R
F
N
PIY
A
DH
Y
A
M
R
GE
--
PGDH
N
G
PTV
F
A
T
H
STHKLL
N
ALSQAS
Y
IHV
REG
-
R
G
AI
N
FS
R
FN
Q
AYMMH
A
TTSP
L
Y
A
I
C
AS
N
DV
A
VS
MM
D
GN
S
G
LS
L
TQ
E
V
I
DE
A
V
D
FR
QA
M
A
---
RL
Y
K
E
FTADGS
WFF
K
P
W
NK
EV
V
T
D
PQTGKTYDFADAPTKLLTTV
Q
D
CW
V
M
H
PGE
S
WHGF
--
KDI
P
D
N
WS
M
LDPIKV
S
IL
A
PGM
G
EDG
E
LE
E
T
G
V
PAALV
TA
W
L
GR
HGIV
PTR
T
TDFQIM
FLFS
M
G
VTRG
K
W
GT
L
VN
T
L
C
S
FKR
H
YD
A
N
TP
L
AQVM
P
E
L
V
E
QY
PD
T
Y
A
NM
G
I
H
DL
GD
T
MFAWL
KE
N
N
PG
A
RL
N
E
A
Y
SG
LP
V
A
E
I
TP
RE
A
Y
N
AI
V
D
N
N
VE
L
V
S
I
E
N
L
P
GRI
A
AN
SVI
PYPPG
I
P
M
L
LS
GE
N
F
G
D
KNS
P
QV
S
Y
L
R
S
L
Q
S
W
D
H
H
F
PGFE
HETE
G
T
EI-I
DG
I
Y
H
V
M
CV
K
fig|83334.1.peg.5077
Escherichia coli O157:H7 (22-755/756)
V
E
R
L
AD
AL
SQ
QN
VTV
I
K
S
T
S
F
DD
GFA
I
LS
S
N
E
A
I
DCLM
F
SYQ
M
E
H
P
D
EH
Q
N
V
R
QL
IGKLHERQQ
N
V
P
VFLL
G
DR
E
KA
L
AAM
DR
---
DL
L
E
-----
L
V
D
E
F
AWI
L
ED
T
A
DF
IA
G
R
AV
A
A
M
T
R
Y
RQQ
L
LPPL
FS
AL
M
KY
S
D
I
H
E
Y
SWAA
PGH
Q
GG
VG
F
T
K
T
P
A
G
R
FYH
D
YY
G
E
N
L
F
R
T
D
M
G
I
ER
T
S
LGSLLDHTG
AF
G
E
S
E
K
Y
A
ARVFGADRS
W
S
V
VV
GTS
G
SN
RTIMQA
C
MT
D
NDV
V
VV
DRNCHKS
I
E
QG
LM
L
T
GA
K
PVY
MV
P
S
RN
R
YGI
I
G
P
I
Y
PQ
E
M
Q
PE
T
L
Q
KK
I
S
E
S
P
LTKDK
A
G
Q
K
P
SYC
V
V
TN
C
TYDG
VC
YN
AK
E
AQ
D
L
L
EK
T
S
DRL
HFD
E
AW
YG
Y
A
R
F
N
PIY
A
DH
Y
A
M
R
GE
--
PGDH
N
G
PTV
F
A
T
H
STHKLL
N
ALSQAS
Y
IHV
REG
-
R
G
AI
N
FS
R
FN
Q
AYMMH
A
TTSP
L
Y
A
I
C
AS
N
DV
A
VS
MM
D
GN
S
G
LS
L
TQ
E
V
I
DE
A
V
D
FR
QA
M
A
---
RL
Y
K
E
F
A
ADGS
WFF
K
P
W
NK
EV
V
T
D
PQTGKTYDFADAPTKLLTTV
Q
D
CW
V
M
H
PGE
S
WHGF
--
KDI
P
D
N
WS
M
LDPIKV
S
IL
A
PGM
G
EDG
E
LE
E
T
G
V
PAALV
TA
W
L
GR
HGIV
PTR
T
TDFQIM
FLFS
M
G
VTRG
K
W
GT
L
VN
T
L
C
S
FKR
H
YD
A
N
TP
L
AQVM
P
E
L
V
E
QY
PD
T
Y
A
NM
G
I
H
DL
GD
T
MFAWL
KE
N
N
PG
A
RL
N
E
A
Y
SG
LP
V
A
E
I
TP
RE
A
Y
N
AI
V
D
N
N
VE
L
V
S
I
E
N
L
P
GRI
A
AN
SVI
PYPPG
I
P
M
L
LS
GE
N
F
G
D
KNS
P
QV
S
Y
L
R
S
L
Q
S
W
D
H
H
F
PGFE
HETE
G
T
EI-I
DG
I
Y
H
V
M
CV
K
fig|155864.1.peg.5058
Escherichia coli O157:H7 EDL933 (22-755/756)
V
E
R
L
AD
AL
SQ
QN
VTV
I
K
S
T
S
F
DD
GFA
I
LS
S
N
E
A
I
DCLM
F
SYQ
M
E
H
P
D
EH
Q
N
V
R
QL
IGKLHERQQ
N
V
P
VFLL
G
DR
E
KA
L
AAM
DR
---
DL
L
E
-----
L
V
D
E
F
AWI
L
ED
T
A
DF
IA
G
R
AV
A
A
M
T
R
Y
RQQ
L
LPPL
FS
AL
M
KY
S
D
I
H
E
Y
SWAA
PGH
Q
GG
VG
F
T
K
T
P
A
G
R
FYH
D
YY
G
E
N
L
F
R
T
D
M
G
I
ER
T
S
LGSLLDHTG
AF
G
E
S
E
K
Y
A
ARVFGADRS
W
S
V
VV
GTS
G
SN
RTIMQA
C
MT
D
NDV
V
VV
DRNCHKS
I
E
QG
LM
L
T
GA
K
PVY
MV
P
S
RN
R
YGI
I
G
P
I
Y
PQ
E
M
Q
PE
T
L
Q
KK
I
S
E
S
P
LTKDK
A
G
Q
K
P
SYC
V
V
TN
C
TYDG
VC
YN
AK
E
AQ
D
L
L
EK
T
S
DRL
HFD
E
AW
YG
Y
A
R
F
N
PIY
A
DH
Y
A
M
R
GE
--
PGDH
N
G
PTV
F
A
T
H
STHKLL
N
ALSQAS
Y
IHV
REG
-
R
G
AI
N
FS
R
FN
Q
AYMMH
A
TTSP
L
Y
A
I
C
AS
N
DV
A
VS
MM
D
GN
S
G
LS
L
TQ
E
V
I
DE
A
V
D
FR
QA
M
A
---
RL
Y
K
E
F
A
ADGS
WFF
K
P
W
NK
EV
V
T
D
PQTGKTYDFADAPTKLLTTV
Q
D
CW
V
M
H
PGE
S
WHGF
--
KDI
P
D
N
WS
M
LDPIKV
S
IL
A
PGM
G
EDG
E
LE
E
T
G
V
PAALV
TA
W
L
GR
HGIV
PTR
T
TDFQIM
FLFS
M
G
VTRG
K
W
GT
L
VN
T
L
C
S
FKR
H
YD
A
N
TP
L
AQVM
P
E
L
V
E
QY
PD
T
Y
A
NM
G
I
H
DL
GD
T
MFAWL
KE
N
N
PG
A
RL
N
E
A
Y
SG
LP
V
A
E
I
TP
RE
A
Y
N
AI
V
D
N
N
VE
L
V
S
I
E
N
L
P
GRI
A
AN
SVI
PYPPG
I
P
M
L
LS
GE
N
F
G
D
KNS
P
QV
S
Y
L
R
S
L
Q
S
W
D
H
H
F
PGFE
HETE
G
T
EI-I
DG
I
Y
H
V
M
CV
K
fig|444454.5.peg.4181
Escherichia coli O157:H7 str. EC4024 (22-755/756)
V
E
R
L
AD
AL
SQ
QN
VTV
I
K
S
T
S
F
DD
GFA
I
LS
S
N
E
A
I
DCLM
F
SYQ
M
E
H
P
D
EH
Q
N
V
R
QL
IGKLHERQQ
N
V
P
VFLL
G
DR
E
KA
L
AAM
DR
---
DL
L
E
-----
L
V
D
E
F
AWI
L
ED
T
A
DF
IA
G
R
AV
A
A
M
T
R
Y
RQQ
L
LPPL
FS
AL
M
KY
S
D
I
H
E
Y
SWAA
PGH
Q
GG
VG
F
T
K
T
P
A
G
R
FYH
D
YY
G
E
N
L
F
R
T
D
M
G
I
ER
T
S
LGSLLDHTG
AF
G
E
S
E
K
Y
A
ARVFGADRS
W
S
V
VV
GTS
G
SN
RTIMQA
C
MT
D
NDV
V
VV
DRNCHKS
I
E
QG
LM
L
T
GA
K
PVY
MV
P
S
RN
R
YGI
I
G
P
I
Y
PQ
E
M
Q
PE
T
L
Q
KK
I
S
E
S
P
LTKDK
A
G
Q
K
P
SYC
V
V
TN
C
TYDG
VC
YN
AK
E
AQ
D
L
L
EK
T
S
DRL
HFD
E
AW
YG
Y
A
R
F
N
PIY
A
DH
Y
A
M
R
GE
--
PGDH
N
G
PTV
F
A
T
H
STHKLL
N
ALSQAS
Y
IHV
REG
-
R
G
AI
N
FS
R
FN
Q
AYMMH
A
TTSP
L
Y
A
I
C
AS
N
DV
A
VS
MM
D
GN
S
G
LS
L
TQ
E
V
I
DE
A
V
D
FR
QA
M
A
---
RL
Y
K
E
F
A
ADGS
WFF
K
P
W
NK
EV
V
T
D
PQTGKTYDFADAPTKLLTTV
Q
D
CW
V
M
H
PGE
S
WHGF
--
KDI
P
D
N
WS
M
LDPIKV
S
IL
A
PGM
G
EDG
E
LE
E
T
G
V
PAALV
TA
W
L
GR
HGIV
PTR
T
TDFQIM
FLFS
M
G
VTRG
K
W
GT
L
VN
T
L
C
S
FKR
H
YD
A
N
TP
L
AQVM
P
E
L
V
E
QY
PD
T
Y
A
NM
G
I
H
DL
GD
T
MFAWL
KE
N
N
PG
A
RL
N
E
A
Y
SG
LP
V
A
E
I
TP
RE
A
Y
N
AI
V
D
N
N
VE
L
V
S
I
E
N
L
P
GRI
A
AN
SVI
PYPPG
I
P
M
L
LS
GE
N
F
G
D
KNS
P
QV
S
Y
L
R
S
L
Q
S
W
D
H
H
F
PGFE
HETE
G
T
EI-I
DG
I
Y
H
V
M
CV
K
fig|444449.5.peg.3635
Escherichia coli O157:H7 str. EC4042 (22-755/756)
V
E
R
L
AD
AL
SQ
QN
VTV
I
K
S
T
S
F
DD
GFA
I
LS
S
N
E
A
I
DCLM
F
SYQ
M
E
H
P
D
EH
Q
N
V
R
QL
IGKLHERQQ
N
V
P
VFLL
G
DR
E
KA
L
AAM
DR
---
DL
L
E
-----
L
V
D
E
F
AWI
L
ED
T
A
DF
IA
G
R
AV
A
A
M
T
R
Y
RQQ
L
LPPL
FS
AL
M
KY
S
D
I
H
E
Y
SWAA
PGH
Q
GG
VG
F
T
K
T
P
A
G
R
FYH
D
YY
G
E
N
L
F
R
T
D
M
G
I
ER
T
S
LGSLLDHTG
AF
G
E
S
E
K
Y
A
ARVFGADRS
W
S
V
VV
GTS
G
SN
RTIMQA
C
MT
D
NDV
V
VV
DRNCHKS
I
E
QG
LM
L
T
GA
K
PVY
MV
P
S
RN
R
YGI
I
G
P
I
Y
PQ
E
M
Q
PE
T
L
Q
KK
I
S
E
S
P
LTKDK
A
G
Q
K
P
SYC
V
V
TN
C
TYDG
VC
YN
AK
E
AQ
D
L
L
EK
T
S
DRL
HFD
E
AW
YG
Y
A
R
F
N
PIY
A
DH
Y
A
M
R
GE
--
PGDH
N
G
PTV
F
A
T
H
STHKLL
N
ALSQAS
Y
IHV
REG
-
R
G
AI
N
FS
R
FN
Q
AYMMH
A
TTSP
L
Y
A
I
C
AS
N
DV
A
VS
MM
D
GN
S
G
LS
L
TQ
E
V
I
DE
A
V
D
FR
QA
M
A
---
RL
Y
K
E
F
A
ADGS
WFF
K
P
W
NK
EV
V
T
D
PQTGKTYDFADAPTKLLTTV
Q
D
CW
V
M
H
PGE
S
WHGF
--
KDI
P
D
N
WS
M
LDPIKV
S
IL
A
PGM
G
EDG
E
LE
E
T
G
V
PAALV
TA
W
L
GR
HGIV
PTR
T
TDFQIM
FLFS
M
G
VTRG
K
W
GT
L
VN
T
L
C
S
FKR
H
YD
A
N
TP
L
AQVM
P
E
L
V
E
QY
PD
T
Y
A
NM
G
I
H
DL
GD
T
MFAWL
KE
N
N
PG
A
RL
N
E
A
Y
SG
LP
V
A
E
I
TP
RE
A
Y
N
AI
V
D
N
N
VE
L
V
S
I
E
N
L
P
GRI
A
AN
SVI
PYPPG
I
P
M
L
LS
GE
N
F
G
D
KNS
P
QV
S
Y
L
R
S
L
Q
S
W
D
H
H
F
PGFE
HETE
G
T
EI-I
DG
I
Y
H
V
M
CV
K
fig|444448.5.peg.2392
Escherichia coli O157:H7 str. EC4045 (21-754/755)
V
E
R
L
AD
AL
SQ
QN
VTV
I
K
S
T
S
F
DD
GFA
I
LS
S
N
E
A
I
DCLM
F
SYQ
M
E
H
P
D
EH
Q
N
V
R
QL
IGKLHERQQ
N
V
P
VFLL
G
DR
E
KA
L
AAM
DR
---
DL
L
E
-----
L
V
D
E
F
AWI
L
ED
T
A
DF
IA
G
R
AV
A
A
M
T
R
Y
RQQ
L
LPPL
FS
AL
M
KY
S
D
I
H
E
Y
SWAA
PGH
Q
GG
VG
F
T
K
T
P
A
G
R
FYH
D
YY
G
E
N
L
F
R
T
D
M
G
I
ER
T
S
LGSLLDHTG
AF
G
E
S
E
K
Y
A
ARVFGADRS
W
S
V
VV
GTS
G
SN
RTIMQA
C
MT
D
NDV
V
VV
DRNCHKS
I
E
QG
LM
L
T
GA
K
PVY
MV
P
S
RN
R
YGI
I
G
P
I
Y
PQ
E
M
Q
PE
T
L
Q
KK
I
S
E
S
P
LTKDK
A
G
Q
K
P
SYC
V
V
TN
C
TYDG
VC
YN
AK
E
AQ
D
L
L
EK
T
S
DRL
HFD
E
AW
YG
Y
A
R
F
N
PIY
A
DH
Y
A
M
R
GE
--
PGDH
N
G
PTV
F
A
T
H
STHKLL
N
ALSQAS
Y
IHV
REG
-
R
G
AI
N
FS
R
FN
Q
AYMMH
A
TTSP
L
Y
A
I
C
AS
N
DV
A
VS
MM
D
GN
S
G
LS
L
TQ
E
V
I
DE
A
V
D
FR
QA
M
A
---
RL
Y
K
E
F
A
ADGS
WFF
K
P
W
NK
EV
V
T
D
PQTGKTYDFADAPTKLLTTV
Q
D
CW
V
M
H
PGE
S
WHGF
--
KDI
P
D
N
WS
M
LDPIKV
S
IL
A
PGM
G
EDG
E
LE
E
T
G
V
PAALV
TA
W
L
GR
HGIV
PTR
T
TDFQIM
FLFS
M
G
VTRG
K
W
GT
L
VN
T
L
C
S
FKR
H
YD
A
N
TP
L
AQVM
P
E
L
V
E
QY
PD
T
Y
A
NM
G
I
H
DL
GD
T
MFAWL
KE
N
N
PG
A
RL
N
E
A
Y
SG
LP
V
A
E
I
TP
RE
A
Y
N
AI
V
D
N
N
VE
L
V
S
I
E
N
L
P
GRI
A
AN
SVI
PYPPG
I
P
M
L
LS
GE
N
F
G
D
KNS
P
QV
S
Y
L
R
S
L
Q
S
W
D
H
H
F
PGFE
HETE
G
T
EI-I
DG
I
Y
H
V
M
CV
K
fig|444453.5.peg.2029
Escherichia coli O157:H7 str. EC4076 (21-754/755)
V
E
R
L
AD
AL
SQ
QN
VTV
I
K
S
T
S
F
DD
GFA
I
LS
S
N
E
A
I
DCLM
F
SYQ
M
E
H
P
D
EH
Q
N
V
R
QL
IGKLHERQQ
N
V
P
VFLL
G
DR
E
KA
L
AAM
DR
---
DL
L
E
-----
L
V
D
E
F
AWI
L
ED
T
A
DF
IA
G
R
AV
A
A
M
T
R
Y
RQQ
L
LPPL
FS
AL
M
KY
S
D
I
H
E
Y
SWAA
PGH
Q
GG
VG
F
T
K
T
P
A
G
R
FYH
D
YY
G
E
N
L
F
R
T
D
M
G
I
ER
T
S
LGSLLDHTG
AF
G
E
S
E
K
Y
A
ARVFGADRS
W
S
V
VV
GTS
G
SN
RTIMQA
C
MT
D
NDV
V
VV
DRNCHKS
I
E
QG
LM
L
T
GA
K
PVY
MV
P
S
RN
R
YGI
I
G
P
I
Y
PQ
E
M
Q
PE
T
L
Q
KK
I
S
E
S
P
LTKDK
A
G
Q
K
P
SYC
V
V
TN
C
TYDG
VC
YN
AK
E
AQ
D
L
L
EK
T
S
DRL
HFD
E
AW
YG
Y
A
R
F
N
PIY
A
DH
Y
A
M
R
GE
--
PGDH
N
G
PTV
F
A
T
H
STHKLL
N
ALSQAS
Y
IHV
REG
-
R
G
AI
N
FS
R
FN
Q
AYMMH
A
TTSP
L
Y
A
I
C
AS
N
DV
A
VS
MM
D
GN
S
G
LS
L
TQ
E
V
I
DE
A
V
D
FR
QA
M
A
---
RL
Y
K
E
F
A
ADGS
WFF
K
P
W
NK
EV
V
T
D
PQTGKTYDFADAPTKLLTTV
Q
D
CW
V
M
H
PGE
S
WHGF
--
KDI
P
D
N
WS
M
LDPIKV
S
IL
A
PGM
G
EDG
E
LE
E
T
G
V
PAALV
TA
W
L
GR
HGIV
PTR
T
TDFQIM
FLFS
M
G
VTRG
K
W
GT
L
VN
T
L
C
S
FKR
H
YD
A
N
TP
L
AQVM
P
E
L
V
E
QY
PD
T
Y
A
NM
G
I
H
DL
GD
T
MFAWL
KE
N
N
PG
A
RL
N
E
A
Y
SG
LP
V
A
E
I
TP
RE
A
Y
N
AI
V
D
N
N
VE
L
V
S
I
E
N
L
P
GRI
A
AN
SVI
PYPPG
I
P
M
L
LS
GE
N
F
G
D
KNS
P
QV
S
Y
L
R
S
L
Q
S
W
D
H
H
F
PGFE
HETE
G
T
EI-I
DG
I
Y
H
V
M
CV
K
fig|444452.5.peg.1134
Escherichia coli O157:H7 str. EC4113 (22-755/756)
V
E
R
L
AD
AL
SQ
QN
VTV
I
K
S
T
S
F
DD
GFA
I
LS
S
N
E
A
I
DCLM
F
SYQ
M
E
H
P
D
EH
Q
N
V
R
QL
IGKLHERQQ
N
V
P
VFLL
G
DR
E
KA
L
AAM
DR
---
DL
L
E
-----
L
V
D
E
F
AWI
L
ED
T
A
DF
IA
G
R
AV
A
A
M
T
R
Y
RQQ
L
LPPL
FS
AL
M
KY
S
D
I
H
E
Y
SWAA
PGH
Q
GG
VG
F
T
K
T
P
A
G
R
FYH
D
YY
G
E
N
L
F
R
T
D
M
G
I
ER
T
S
LGSLLDHTG
AF
G
E
S
E
K
Y
A
ARVFGADRS
W
S
V
VV
GTS
G
SN
RTIMQA
C
MT
D
NDV
V
VV
DRNCHKS
I
E
QG
LM
L
T
GA
K
PVY
MV
P
S
RN
R
YGI
I
G
P
I
Y
PQ
E
M
Q
PE
T
L
Q
KK
I
S
E
S
P
LTKDK
A
G
Q
K
P
SYC
V
V
TN
C
TYDG
VC
YN
AK
E
AQ
D
L
L
EK
T
S
DRL
HFD
E
AW
YG
Y
A
R
F
N
PIY
A
DH
Y
A
M
R
GE
--
PGDH
N
G
PTV
F
A
T
H
STHKLL
N
ALSQAS
Y
IHV
REG
-
R
G
AI
N
FS
R
FN
Q
AYMMH
A
TTSP
L
Y
A
I
C
AS
N
DV
A
VS
MM
D
GN
S
G
LS
L
TQ
E
V
I
DE
A
V
D
FR
QA
M
A
---
RL
Y
K
E
F
A
ADGS
WFF
K
P
W
NK
EV
V
T
D
PQTGKTYDFADAPTKLLTTV
Q
D
CW
V
M
H
PGE
S
WHGF
--
KDI
P
D
N
WS
M
LDPIKV
S
IL
A
PGM
G
EDG
E
LE
E
T
G
V
PAALV
TA
W
L
GR
HGIV
PTR
T
TDFQIM
FLFS
M
G
VTRG
K
W
GT
L
VN
T
L
C
S
FKR
H
YD
A
N
TP
L
AQVM
P
E
L
V
E
QY
PD
T
Y
A
NM
G
I
H
DL
GD
T
MFAWL
KE
N
N
PG
A
RL
N
E
A
Y
SG
LP
V
A
E
I
TP
RE
A
Y
N
AI
V
D
N
N
VE
L
V
S
I
E
N
L
P
GRI
A
AN
SVI
PYPPG
I
P
M
L
LS
GE
N
F
G
D
KNS
P
QV
S
Y
L
R
S
L
Q
S
W
D
H
H
F
PGFE
HETE
G
T
EI-I
DG
I
Y
H
V
M
CV
K
fig|444450.8.peg.5471
Escherichia coli O157:H7 str. EC4115 (22-755/756)
V
E
R
L
AD
AL
SQ
QN
VTV
I
K
S
T
S
F
DD
GFA
I
LS
S
N
E
A
I
DCLM
F
SYQ
M
E
H
P
D
EH
Q
N
V
R
QL
IGKLHERQQ
N
V
P
VFLL
G
DR
E
KA
L
AAM
DR
---
DL
L
E
-----
L
V
D
E
F
AWI
L
ED
T
A
DF
IA
G
R
AV
A
A
M
T
R
Y
RQQ
L
LPPL
FS
AL
M
KY
S
D
I
H
E
Y
SWAA
PGH
Q
GG
VG
F
T
K
T
P
A
G
R
FYH
D
YY
G
E
N
L
F
R
T
D
M
G
I
ER
T
S
LGSLLDHTG
AF
G
E
S
E
K
Y
A
ARVFGADRS
W
S
V
VV
GTS
G
SN
RTIMQA
C
MT
D
NDV
V
VV
DRNCHKS
I
E
QG
LM
L
T
GA
K
PVY
MV
P
S
RN
R
YGI
I
G
P
I
Y
PQ
E
M
Q
PE
T
L
Q
KK
I
S
E
S
P
LTKDK
A
G
Q
K
P
SYC
V
V
TN
C
TYDG
VC
YN
AK
E
AQ
D
L
L
EK
T
S
DRL
HFD
E
AW
YG
Y
A
R
F
N
PIY
A
DH
Y
A
M
R
GE
--
PGDH
N
G
PTV
F
A
T
H
STHKLL
N
ALSQAS
Y
IHV
REG
-
R
G
AI
N
FS
R
FN
Q
AYMMH
A
TTSP
L
Y
A
I
C
AS
N
DV
A
VS
MM
D
GN
S
G
LS
L
TQ
E
V
I
DE
A
V
D
FR
QA
M
A
---
RL
Y
K
E
F
A
ADGS
WFF
K
P
W
NK
EV
V
T
D
PQTGKTYDFADAPTKLLTTV
Q
D
CW
V
M
H
PGE
S
WHGF
--
KDI
P
D
N
WS
M
LDPIKV
S
IL
A
PGM
G
EDG
E
LE
E
T
G
V
PAALV
TA
W
L
GR
HGIV
PTR
T
TDFQIM
FLFS
M
G
VTRG
K
W
GT
L
VN
T
L
C
S
FKR
H
YD
A
N
TP
L
AQVM
P
E
L
V
E
QY
PD
T
Y
A
NM
G
I
H
DL
GD
T
MFAWL
KE
N
N
PG
A
RL
N
E
A
Y
SG
LP
V
A
E
I
TP
RE
A
Y
N
AI
V
D
N
N
VE
L
V
S
I
E
N
L
P
GRI
A
AN
SVI
PYPPG
I
P
M
L
LS
GE
N
F
G
D
KNS
P
QV
S
Y
L
R
S
L
Q
S
W
D
H
H
F
PGFE
HETE
G
T
EI-I
DG
I
Y
H
V
M
CV
K
fig|444451.5.peg.2133
Escherichia coli O157:H7 str. EC4196 (22-755/756)
V
E
R
L
AD
AL
SQ
QN
VTV
I
K
S
T
S
F
DD
GFA
I
LS
S
N
E
A
I
DCLM
F
SYQ
M
E
H
P
D
EH
Q
N
V
R
QL
IGKLHERQQ
N
V
P
VFLL
G
DR
E
KA
L
AAM
DR
---
DL
L
E
-----
L
V
D
E
F
AWI
L
ED
T
A
DF
IA
G
R
AV
A
A
M
T
R
Y
RQQ
L
LPPL
FS
AL
M
KY
S
D
I
H
E
Y
SWAA
PGH
Q
GG
VG
F
T
K
T
P
A
G
R
FYH
D
YY
G
E
N
L
F
R
T
D
M
G
I
ER
T
S
LGSLLDHTG
AF
G
E
S
E
K
Y
A
ARVFGADRS
W
S
V
VV
GTS
G
SN
RTIMQA
C
MT
D
NDV
V
VV
DRNCHKS
I
E
QG
LM
L
T
GA
K
PVY
MV
P
S
RN
R
YGI
I
G
P
I
Y
PQ
E
M
Q
PE
T
L
Q
KK
I
S
E
S
P
LTKDK
A
G
Q
K
P
SYC
V
V
TN
C
TYDG
VC
YN
AK
E
AQ
D
L
L
EK
T
S
DRL
HFD
E
AW
YG
Y
A
R
F
N
PIY
A
DH
Y
A
M
R
GE
--
PGDH
N
G
PTV
F
A
T
H
STHKLL
N
ALSQAS
Y
IHV
REG
-
R
G
AI
N
FS
R
FN
Q
AYMMH
A
TTSP
L
Y
A
I
C
AS
N
DV
A
VS
MM
D
GN
S
G
LS
L
TQ
E
V
I
DE
A
V
D
FR
QA
M
A
---
RL
Y
K
E
F
A
ADGS
WFF
K
P
W
NK
EV
V
T
D
PQTGKTYDFADAPTKLLTTV
Q
D
CW
V
M
H
PGE
S
WHGF
--
KDI
P
D
N
WS
M
LDPIKV
S
IL
A
PGM
G
EDG
E
LE
E
T
G
V
PAALV
TA
W
L
GR
HGIV
PTR
T
TDFQIM
FLFS
M
G
VTRG
K
W
GT
L
VN
T
L
C
S
FKR
H
YD
A
N
TP
L
AQVM
P
E
L
V
E
QY
PD
T
Y
A
NM
G
I
H
DL
GD
T
MFAWL
KE
N
N
PG
A
RL
N
E
A
Y
SG
LP
V
A
E
I
TP
RE
A
Y
N
AI
V
D
N
N
VE
L
V
S
I
E
N
L
P
GRI
A
AN
SVI
PYPPG
I
P
M
L
LS
GE
N
F
G
D
KNS
P
QV
S
Y
L
R
S
L
Q
S
W
D
H
H
F
PGFE
HETE
G
T
EI-I
DG
I
Y
H
V
M
CV
K
fig|444447.5.peg.2558
Escherichia coli O157:H7 str. EC4206 (22-755/756)
V
E
R
L
AD
AL
SQ
QN
VTV
I
K
S
T
S
F
DD
GFA
I
LS
S
N
E
A
I
DCLM
F
SYQ
M
E
H
P
D
EH
Q
N
V
R
QL
IGKLHERQQ
N
V
P
VFLL
G
DR
E
KA
L
AAM
DR
---
DL
L
E
-----
L
V
D
E
F
AWI
L
ED
T
A
DF
IA
G
R
AV
A
A
M
T
R
Y
RQQ
L
LPPL
FS
AL
M
KY
S
D
I
H
E
Y
SWAA
PGH
Q
GG
VG
F
T
K
T
P
A
G
R
FYH
D
YY
G
E
N
L
F
R
T
D
M
G
I
ER
T
S
LGSLLDHTG
AF
G
E
S
E
K
Y
A
ARVFGADRS
W
S
V
VV
GTS
G
SN
RTIMQA
C
MT
D
NDV
V
VV
DRNCHKS
I
E
QG
LM
L
T
GA
K
PVY
MV
P
S
RN
R
YGI
I
G
P
I
Y
PQ
E
M
Q
PE
T
L
Q
KK
I
S
E
S
P
LTKDK
A
G
Q
K
P
SYC
V
V
TN
C
TYDG
VC
YN
AK
E
AQ
D
L
L
EK
T
S
DRL
HFD
E
AW
YG
Y
A
R
F
N
PIY
A
DH
Y
A
M
R
GE
--
PGDH
N
G
PTV
F
A
T
H
STHKLL
N
ALSQAS
Y
IHV
REG
-
R
G
AI
N
FS
R
FN
Q
AYMMH
A
TTSP
L
Y
A
I
C
AS
N
DV
A
VS
MM
D
GN
S
G
LS
L
TQ
E
V
I
DE
A
V
D
FR
QA
M
A
---
RL
Y
K
E
F
A
ADGS
WFF
K
P
W
NK
EV
V
T
D
PQTGKTYDFADAPTKLLTTV
Q
D
CW
V
M
H
PGE
S
WHGF
--
KDI
P
D
N
WS
M
LDPIKV
S
IL
A
PGM
G
EDG
E
LE
E
T
G
V
PAALV
TA
W
L
GR
HGIV
PTR
T
TDFQIM
FLFS
M
G
VTRG
K
W
GT
L
VN
T
L
C
S
FKR
H
YD
A
N
TP
L
AQVM
P
E
L
V
E
QY
PD
T
Y
A
NM
G
I
H
DL
GD
T
MFAWL
KE
N
N
PG
A
RL
N
E
A
Y
SG
LP
V
A
E
I
TP
RE
A
Y
N
AI
V
D
N
N
VE
L
V
S
I
E
N
L
P
GRI
A
AN
SVI
PYPPG
I
P
M
L
LS
GE
N
F
G
D
KNS
P
QV
S
Y
L
R
S
L
Q
S
W
D
H
H
F
PGFE
HETE
G
T
EI-I
DG
I
Y
H
V
M
CV
K
fig|478004.5.peg.2081
Escherichia coli O157:H7 str. EC4401 (22-755/756)
V
E
R
L
AD
AL
SQ
QN
VTV
I
K
S
T
S
F
DD
GFA
I
LS
S
N
E
A
I
DCLM
F
SYQ
M
E
H
P
D
EH
Q
N
V
R
QL
IGKLHERQQ
N
V
P
VFLL
G
DR
E
KA
L
AAM
DR
---
DL
L
E
-----
L
V
D
E
F
AWI
L
ED
T
A
DF
IA
G
R
AV
A
A
M
T
R
Y
RQQ
L
LPPL
FS
AL
M
KY
S
D
I
H
E
Y
SWAA
PGH
Q
GG
VG
F
T
K
T
P
A
G
R
FYH
D
YY
G
E
N
L
F
R
T
D
M
G
I
ER
T
S
LGSLLDHTG
AF
G
E
S
E
K
Y
A
ARVFGADRS
W
S
V
VV
GTS
G
SN
RTIMQA
C
MT
D
NDV
V
VV
DRNCHKS
I
E
QG
LM
L
T
GA
K
PVY
MV
P
S
RN
R
YGI
I
G
P
I
Y
PQ
E
M
Q
PE
T
L
Q
KK
I
S
E
S
P
LTKDK
A
G
Q
K
P
SYC
V
V
TN
C
TYDG
VC
YN
AK
E
AQ
D
L
L
EK
T
S
DRL
HFD
E
AW
YG
Y
A
R
F
N
PIY
A
DH
Y
A
M
R
GE
--
PGDH
N
G
PTV
F
A
T
H
STHKLL
N
ALSQAS
Y
IHV
REG
-
R
G
AI
N
FS
R
FN
Q
AYMMH
A
TTSP
L
Y
A
I
C
AS
N
DV
A
VS
MM
D
GN
S
G
LS
L
TQ
E
V
I
DE
A
V
D
FR
QA
M
A
---
RL
Y
K
E
F
A
ADGS
WFF
K
P
W
NK
EV
V
T
D
PQTGKTYDFADAPTKLLTTV
Q
D
CW
V
M
H
PGE
S
WHGF
--
KDI
P
D
N
WS
M
LDPIKV
S
IL
A
PGM
G
EDG
E
LE
E
T
G
V
PAALV
TA
W
L
GR
HGIV
PTR
T
TDFQIM
FLFS
M
G
VTRG
K
W
GT
L
VN
T
L
C
S
FKR
H
YD
A
N
TP
L
AQVM
P
E
L
V
E
QY
PD
T
Y
A
NM
G
I
H
DL
GD
T
MFAWL
KE
N
N
PG
A
RL
N
E
A
Y
SG
LP
V
A
E
I
TP
RE
A
Y
N
AI
V
D
N
N
VE
L
V
S
I
E
N
L
P
GRI
A
AN
SVI
PYPPG
I
P
M
L
LS
GE
N
F
G
D
KNS
P
QV
S
Y
L
R
S
L
Q
S
W
D
H
H
F
PGFE
HETE
G
T
EI-I
DG
I
Y
H
V
M
CV
K
fig|478005.5.peg.611
Escherichia coli O157:H7 str. EC4486 (22-755/756)
V
E
R
L
AD
AL
SQ
QN
VTV
I
K
S
T
S
F
DD
GFA
I
LS
S
N
E
A
I
DCLM
F
SYQ
M
E
H
P
D
EH
Q
N
V
R
QL
IGKLHERQQ
N
V
P
VFLL
G
DR
E
KA
L
AAM
DR
---
DL
L
E
-----
L
V
D
E
F
AWI
L
ED
T
A
DF
IA
G
R
AV
A
A
M
T
R
Y
RQQ
L
LPPL
FS
AL
M
KY
S
D
I
H
E
Y
SWAA
PGH
Q
GG
VG
F
T
K
T
P
A
G
R
FYH
D
YY
G
E
N
L
F
R
T
D
M
G
I
ER
T
S
LGSLLDHTG
AF
G
E
S
E
K
Y
A
ARVFGADRS
W
S
V
VV
GTS
G
SN
RTIMQA
C
MT
D
NDV
V
VV
DRNCHKS
I
E
QG
LM
L
T
GA
K
PVY
MV
P
S
RN
R
YGI
I
G
P
I
Y
PQ
E
M
Q
PE
T
L
Q
KK
I
S
E
S
P
LTKDK
A
G
Q
K
P
SYC
V
V
TN
C
TYDG
VC
YN
AK
E
AQ
D
L
L
EK
T
S
DRL
HFD
E
AW
YG
Y
A
R
F
N
PIY
A
DH
Y
A
M
R
GE
--
PGDH
N
G
PTV
F
A
T
H
STHKLL
N
ALSQAS
Y
IHV
REG
-
R
G
AI
N
FS
R
FN
Q
AYMMH
A
TTSP
L
Y
A
I
C
AS
N
DV
A
VS
MM
D
GN
S
G
LS
L
TQ
E
V
I
DE
A
V
D
FR
QA
M
A
---
RL
Y
K
E
F
A
ADGS
WFF
K
P
W
NK
EV
V
T
D
PQTGKTYDFADAPTKLLTTV
Q
D
CW
V
M
H
PGE
S
WHGF
--
KDI
P
D
N
WS
M
LDPIKV
S
IL
A
PGM
G
EDG
E
LE
E
T
G
V
PAALV
TA
W
L
GR
HGIV
PTR
T
TDFQIM
FLFS
M
G
VTRG
K
W
GT
L
VN
T
L
C
S
FKR
H
YD
A
N
TP
L
AQVM
P
E
L
V
E
QY
PD
T
Y
A
NM
G
I
H
DL
GD
T
MFAWL
KE
N
N
PG
A
RL
N
E
A
Y
SG
LP
V
A
E
I
TP
RE
A
Y
N
AI
V
D
N
N
VE
L
V
S
I
E
N
L
P
GRI
A
AN
SVI
PYPPG
I
P
M
L
LS
GE
N
F
G
D
KNS
P
QV
S
Y
L
R
S
L
Q
S
W
D
H
H
F
PGFE
HETE
G
T
EI-I
DG
I
Y
H
V
M
CV
K
fig|478006.5.peg.1495
Escherichia coli O157:H7 str. EC4501 (22-755/756)
V
E
R
L
AD
AL
SQ
QN
VTV
I
K
S
T
S
F
DD
GFA
I
LS
S
N
E
A
I
DCLM
F
SYQ
M
E
H
P
D
EH
Q
N
V
R
QL
IGKLHERQQ
N
V
P
VFLL
G
DR
E
KA
L
AAM
DR
---
DL
L
E
-----
L
V
D
E
F
AWI
L
ED
T
A
DF
IA
G
R
AV
A
A
M
T
R
Y
RQQ
L
LPPL
FS
AL
M
KY
S
D
I
H
E
Y
SWAA
PGH
Q
GG
VG
F
T
K
T
P
A
G
R
FYH
D
YY
G
E
N
L
F
R
T
D
M
G
I
ER
T
S
LGSLLDHTG
AF
G
E
S
E
K
Y
A
ARVFGADRS
W
S
V
VV
GTS
G
SN
RTIMQA
C
MT
D
NDV
V
VV
DRNCHKS
I
E
QG
LM
L
T
GA
K
PVY
MV
P
S
RN
R
YGI
I
G
P
I
Y
PQ
E
M
Q
PE
T
L
Q
KK
I
S
E
S
P
LTKDK
A
G
Q
K
P
SYC
V
V
TN
C
TYDG
VC
YN
AK
E
AQ
D
L
L
EK
T
S
DRL
HFD
E
AW
YG
Y
A
R
F
N
PIY
A
DH
Y
A
M
R
GE
--
PGDH
N
G
PTV
F
A
T
H
STHKLL
N
ALSQAS
Y
IHV
REG
-
R
G
AI
N
FS
R
FN
Q
AYMMH
A
TTSP
L
Y
A
I
C
AS
N
DV
A
VS
MM
D
GN
S
G
LS
L
TQ
E
V
I
DE
A
V
D
FR
QA
M
A
---
RL
Y
K
E
F
A
ADGS
WFF
K
P
W
NK
EV
V
T
D
PQTGKTYDFADAPTKLLTTV
Q
D
CW
V
M
H
PGE
S
WHGF
--
KDI
P
D
N
WS
M
LDPIKV
S
IL
A
PGM
G
EDG
E
LE
E
T
G
V
PAALV
TA
W
L
GR
HGIV
PTR
T
TDFQIM
FLFS
M
G
VTRG
K
W
GT
L
VN
T
L
C
S
FKR
H
YD
A
N
TP
L
AQVM
P
E
L
V
E
QY
PD
T
Y
A
NM
G
I
H
DL
GD
T
MFAWL
KE
N
N
PG
A
RL
N
E
A
Y
SG
LP
V
A
E
I
TP
RE
A
Y
N
AI
V
D
N
N
VE
L
V
S
I
E
N
L
P
GRI
A
AN
SVI
PYPPG
I
P
M
L
LS
GE
N
F
G
D
KNS
P
QV
S
Y
L
R
S
L
Q
S
W
D
H
H
F
PGFE
HETE
G
T
EI-I
DG
I
Y
H
V
M
CV
K
fig|478007.5.peg.1042
Escherichia coli O157:H7 str. EC508 (22-755/756)
V
E
R
L
AD
AL
SQ
QN
VTV
I
K
S
T
S
F
DD
GFA
I
LS
S
N
E
A
I
DCLM
F
SYQ
M
E
H
P
D
EH
Q
N
V
R
QL
IGKLHERQQ
N
V
P
VFLL
G
DR
E
KA
L
AAM
DR
---
DL
L
E
-----
L
V
D
E
F
AWI
L
ED
T
A
DF
IA
G
R
AV
A
A
M
T
R
Y
RQQ
L
LPPL
FS
AL
M
KY
S
D
I
H
E
Y
SWAA
PGH
Q
GG
VG
F
T
K
T
P
A
G
R
FYH
D
YY
G
E
N
L
F
R
T
D
M
G
I
ER
T
S
LGSLLDHTG
AF
G
E
S
E
K
Y
A
ARVFGADRS
W
S
V
VV
GTS
G
SN
RTIMQA
C
MT
D
NDV
V
VV
DRNCHKS
I
E
QG
LM
L
T
GA
K
PVY
MV
P
S
RN
R
YGI
I
G
P
I
Y
PQ
E
M
Q
PE
T
L
Q
KK
I
S
E
S
P
LTKDK
A
G
Q
K
P
SYC
V
V
TN
C
TYDG
VC
YN
AK
E
AQ
D
L
L
EK
T
S
DRL
HFD
E
AW
YG
Y
A
R
F
N
PIY
A
DH
Y
A
M
R
GE
--
PGDH
N
G
PTV
F
A
T
H
STHKLL
N
ALSQAS
Y
IHV
REG
-
R
G
AI
N
FS
R
FN
Q
AYMMH
A
TTSP
L
Y
A
I
C
AS
N
DV
A
VS
MM
D
GN
S
G
LS
L
TQ
E
V
I
DE
A
V
D
FR
QA
M
A
---
RL
Y
K
E
F
A
ADGS
WFF
K
P
W
NK
EV
V
T
D
PQTGKTYDFADAPTKLLTTV
Q
D
CW
V
M
H
PGE
S
WHGF
--
KDI
P
D
N
WS
M
LDPIKV
S
IL
A
PGM
G
EDG
E
LE
E
T
G
V
PAALV
TA
W
L
GR
HGIV
PTR
T
TDFQIM
FLFS
M
G
VTRG
K
W
GT
L
VN
T
L
C
S
FKR
H
YD
A
N
TP
L
AQVM
P
E
L
V
E
QY
PD
T
Y
A
NM
G
I
H
DL
GD
T
MFAWL
KE
N
N
PG
A
RL
N
E
A
Y
SG
LP
V
A
E
I
TP
RE
A
Y
N
AI
V
D
N
N
VE
L
V
S
I
E
N
L
P
GRI
A
AN
SVI
PYPPG
I
P
M
L
LS
GE
N
F
G
D
KNS
P
QV
S
Y
L
R
S
L
Q
S
W
D
H
H
F
PGFE
HETE
G
T
EI-I
DG
I
Y
H
V
M
CV
K
fig|478008.5.peg.144
Escherichia coli O157:H7 str. EC869 (22-755/756)
V
E
R
L
AD
AL
SQ
QN
VTV
I
K
S
T
S
F
DD
GFA
I
LS
S
N
E
A
I
DCLM
F
SYQ
M
E
H
P
D
EH
Q
N
V
R
QL
IGKLHERQQ
N
V
P
VFLL
G
DR
E
KA
L
AAM
DR
---
DL
L
E
-----
L
V
D
E
F
AWI
L
ED
T
A
DF
IA
G
R
AV
A
A
M
T
R
Y
RQQ
L
LPPL
FS
AL
M
KY
S
D
I
H
E
Y
SWAA
PGH
Q
GG
VG
F
T
K
T
P
A
G
R
FYH
D
YY
G
E
N
L
F
R
T
D
M
G
I
ER
T
S
LGSLLDHTG
AF
G
E
S
E
K
Y
A
ARVFGADRS
W
S
V
VV
GTS
G
SN
RTIMQA
C
MT
D
NDV
V
VV
DRNCHKS
I
E
QG
LM
L
T
GA
K
PVY
MV
P
S
RN
R
YGI
I
G
P
I
Y
PQ
E
M
Q
PE
T
L
Q
KK
I
S
E
S
P
LTKDK
A
G
Q
K
P
SYC
V
V
TN
C
TYDG
VC
YN
AK
E
AQ
D
L
L
EK
T
S
DRL
HFD
E
AW
YG
Y
A
R
F
N
PIY
A
DH
Y
A
M
R
GE
--
PGDH
N
G
PTV
F
A
T
H
STHKLL
N
ALSQAS
Y
IHV
REG
-
R
G
AI
N
FS
R
FN
Q
AYMMH
A
TTSP
L
Y
A
I
C
AS
N
DV
A
VS
MM
D
GN
S
G
LS
L
TQ
E
V
I
DE
A
V
D
FR
QA
M
A
---
RL
Y
K
E
F
A
ADGS
WFF
K
P
W
NK
EV
V
T
D
PQTGKTYDFADAPTKLLTTV
Q
D
CW
V
M
H
PGE
S
WHGF
--
KDI
P
D
N
WS
M
LDPIKV
S
IL
A
PGM
G
EDG
E
LE
E
T
G
V
PAALV
TA
W
L
GR
HGIV
PTR
T
TDFQIM
FLFS
M
G
VTRG
K
W
GT
L
VN
T
L
C
S
FKR
H
YD
A
N
TP
L
AQVM
P
E
L
V
E
QY
PD
T
Y
A
NM
G
I
H
DL
GD
T
MFAWL
KE
N
N
PG
A
RL
N
E
A
Y
SG
LP
V
A
E
I
TP
RE
A
Y
N
AI
V
D
N
N
VE
L
V
S
I
E
N
L
P
GRI
A
AN
SVI
PYPPG
I
P
M
L
LS
GE
N
F
G
D
KNS
P
QV
S
Y
L
R
S
L
Q
S
W
D
H
H
F
PGFE
HETE
G
T
EI-I
DG
I
Y
H
V
M
CV
K
fig|637388.3.peg.2357
Escherichia coli O157:H7 str. FRIK2000 (22-755/756)
V
E
R
L
AD
AL
SQ
QN
VTV
I
K
S
T
S
F
DD
GFA
I
LS
S
N
E
A
I
DCLM
F
SYQ
M
E
H
P
D
EH
Q
N
V
R
QL
IGKLHERQQ
N
V
P
VFLL
G
DR
E
KA
L
AAM
DR
---
DL
L
E
-----
L
V
D
E
F
AWI
L
ED
T
A
DF
IA
G
R
AV
A
A
M
T
R
Y
RQQ
L
LPPL
FS
AL
M
KY
S
D
I
H
E
Y
SWAA
PGH
Q
GG
VG
F
T
K
T
P
A
G
R
FYH
D
YY
G
E
N
L
F
R
T
D
M
G
I
ER
T
S
LGSLLDHTG
AF
G
E
S
E
K
Y
A
ARVFGADRS
W
S
V
VV
GTS
G
SN
RTIMQA
C
MT
D
NDV
V
VV
DRNCHKS
I
E
QG
LM
L
T
GA
K
PVY
MV
P
S
RN
R
YGI
I
G
P
I
Y
PQ
E
M
Q
PE
T
L
Q
KK
I
S
E
S
P
LTKDK
A
G
Q
K
P
SYC
V
V
TN
C
TYDG
VC
YN
AK
E
AQ
D
L
L
EK
T
S
DRL
HFD
E
AW
YG
Y
A
R
F
N
PIY
A
DH
Y
A
M
R
GE
--
PGDH
N
G
PTV
F
A
T
H
STHKLL
N
ALSQAS
Y
IHV
REG
-
R
G
AI
N
FS
R
FN
Q
AYMMH
A
TTSP
L
Y
A
I
C
AS
N
DV
A
VS
MM
D
GN
S
G
LS
L
TQ
E
V
I
DE
A
V
D
FR
QA
M
A
---
RL
Y
K
E
F
A
ADGS
WFF
K
P
W
NK
EV
V
T
D
PQTGKTYDFADAPTKLLTTV
Q
D
CW
V
M
H
PGE
S
WHGF
--
KDI
P
D
N
WS
M
LDPIKV
S
IL
A
PGM
G
EDG
E
LE
E
T
G
V
PAALV
TA
W
L
GR
HGIV
PTR
T
TDFQIM
FLFS
M
G
VTRG
K
W
GT
L
VN
T
L
C
S
FKR
H
YD
A
N
TP
L
AQVM
P
E
L
V
E
QY
PD
T
Y
A
NM
G
I
H
DL
GD
T
MFAWL
KE
N
N
PG
A
RL
N
E
A
Y
SG
LP
V
A
E
I
TP
RE
A
Y
N
AI
V
D
N
N
VE
L
V
S
I
E
N
L
P
GRI
A
AN
SVI
PYPPG
I
P
M
L
LS
GE
N
F
G
D
KNS
P
QV
S
Y
L
R
S
L
Q
S
W
D
H
H
F
PGFE
HETE
G
T
EI-I
DG
I
Y
H
V
M
CV
K
fig|570506.3.peg.1366
Escherichia coli O157:H7 str. FRIK966 (22-755/756)
V
E
R
L
AD
AL
SQ
QN
VTV
I
K
S
T
S
F
DD
GFA
I
LS
S
N
E
A
I
DCLM
F
SYQ
M
E
H
P
D
EH
Q
N
V
R
QL
IGKLHERQQ
N
V
P
VFLL
G
DR
E
KA
L
AAM
DR
---
DL
L
E
-----
L
V
D
E
F
AWI
L
ED
T
A
DF
IA
G
R
AV
A
A
M
T
R
Y
RQQ
L
LPPL
FS
AL
M
KY
S
D
I
H
E
Y
SWAA
PGH
Q
GG
VG
F
T
K
T
P
A
G
R
FYH
D
YY
G
E
N
L
F
R
T
D
M
G
I
ER
T
S
LGSLLDHTG
AF
G
E
S
E
K
Y
A
ARVFGADRS
W
S
V
VV
GTS
G
SN
RTIMQA
C
MT
D
NDV
V
VV
DRNCHKS
I
E
QG
LM
L
T
GA
K
PVY
MV
P
S
RN
R
YGI
I
G
P
I
Y
PQ
E
M
Q
PE
T
L
Q
KK
I
S
E
S
P
LTKDK
A
G
Q
K
P
SYC
V
V
TN
C
TYDG
VC
YN
AK
E
AQ
D
L
L
EK
T
S
DRL
HFD
E
AW
YG
Y
A
R
F
N
PIY
A
DH
Y
A
M
R
GE
--
PGDH
N
G
PTV
F
A
T
H
STHKLL
N
ALSQAS
Y
IHV
REG
-
R
G
AI
N
FS
R
FN
Q
AYMMH
A
TTSP
L
Y
A
I
C
AS
N
DV
A
VS
MM
D
GN
S
G
LS
L
TQ
E
V
I
DE
A
V
D
FR
QA
M
A
---
RL
Y
K
E
F
A
ADGS
WFF
K
P
W
NK
EV
V
T
D
PQTGKTYDFADAPTKLLTTV
Q
D
CW
V
M
H
PGE
S
WHGF
--
KDI
P
D
N
WS
M
LDPIKV
S
IL
A
PGM
G
EDG
E
LE
E
T
G
V
PAALV
TA
W
L
GR
HGIV
PTR
T
TDFQIM
FLFS
M
G
VTRG
K
W
GT
L
VN
T
L
C
S
FKR
H
YD
A
N
TP
L
AQVM
P
E
L
V
E
QY
PD
T
Y
A
NM
G
I
H
DL
GD
T
MFAWL
KE
N
N
PG
A
RL
N
E
A
Y
SG
LP
V
A
E
I
TP
RE
A
Y
N
AI
V
D
N
N
VE
L
V
S
I
E
N
L
P
GRI
A
AN
SVI
PYPPG
I
P
M
L
LS
GE
N
F
G
D
KNS
P
QV
S
Y
L
R
S
L
Q
S
W
D
H
H
F
PGFE
HETE
G
T
EI-I
DG
I
Y
H
V
M
CV
K
fig|386585.9.peg.5329
Escherichia coli O157:H7 str. Sakai (22-755/756)
V
E
R
L
AD
AL
SQ
QN
VTV
I
K
S
T
S
F
DD
GFA
I
LS
S
N
E
A
I
DCLM
F
SYQ
M
E
H
P
D
EH
Q
N
V
R
QL
IGKLHERQQ
N
V
P
VFLL
G
DR
E
KA
L
AAM
DR
---
DL
L
E
-----
L
V
D
E
F
AWI
L
ED
T
A
DF
IA
G
R
AV
A
A
M
T
R
Y
RQQ
L
LPPL
FS
AL
M
KY
S
D
I
H
E
Y
SWAA
PGH
Q
GG
VG
F
T
K
T
P
A
G
R
FYH
D
YY
G
E
N
L
F
R
T
D
M
G
I
ER
T
S
LGSLLDHTG
AF
G
E
S
E
K
Y
A
ARVFGADRS
W
S
V
VV
GTS
G
SN
RTIMQA
C
MT
D
NDV
V
VV
DRNCHKS
I
E
QG
LM
L
T
GA
K
PVY
MV
P
S
RN
R
YGI
I
G
P
I
Y
PQ
E
M
Q
PE
T
L
Q
KK
I
S
E
S
P
LTKDK
A
G
Q
K
P
SYC
V
V
TN
C
TYDG
VC
YN
AK
E
AQ
D
L
L
EK
T
S
DRL
HFD
E
AW
YG
Y
A
R
F
N
PIY
A
DH
Y
A
M
R
GE
--
PGDH
N
G
PTV
F
A
T
H
STHKLL
N
ALSQAS
Y
IHV
REG
-
R
G
AI
N
FS
R
FN
Q
AYMMH
A
TTSP
L
Y
A
I
C
AS
N
DV
A
VS
MM
D
GN
S
G
LS
L
TQ
E
V
I
DE
A
V
D
FR
QA
M
A
---
RL
Y
K
E
F
A
ADGS
WFF
K
P
W
NK
EV
V
T
D
PQTGKTYDFADAPTKLLTTV
Q
D
CW
V
M
H
PGE
S
WHGF
--
KDI
P
D
N
WS
M
LDPIKV
S
IL
A
PGM
G
EDG
E
LE
E
T
G
V
PAALV
TA
W
L
GR
HGIV
PTR
T
TDFQIM
FLFS
M
G
VTRG
K
W
GT
L
VN
T
L
C
S
FKR
H
YD
A
N
TP
L
AQVM
P
E
L
V
E
QY
PD
T
Y
A
NM
G
I
H
DL
GD
T
MFAWL
KE
N
N
PG
A
RL
N
E
A
Y
SG
LP
V
A
E
I
TP
RE
A
Y
N
AI
V
D
N
N
VE
L
V
S
I
E
N
L
P
GRI
A
AN
SVI
PYPPG
I
P
M
L
LS
GE
N
F
G
D
KNS
P
QV
S
Y
L
R
S
L
Q
S
W
D
H
H
F
PGFE
HETE
G
T
EI-I
DG
I
Y
H
V
M
CV
K
fig|544404.4.peg.5283
Escherichia coli O157:H7 str. TW14359 (22-755/756)
V
E
R
L
AD
AL
SQ
QN
VTV
I
K
S
T
S
F
DD
GFA
I
LS
S
N
E
A
I
DCLM
F
SYQ
M
E
H
P
D
EH
Q
N
V
R
QL
IGKLHERQQ
N
V
P
VFLL
G
DR
E
KA
L
AAM
DR
---
DL
L
E
-----
L
V
D
E
F
AWI
L
ED
T
A
DF
IA
G
R
AV
A
A
M
T
R
Y
RQQ
L
LPPL
FS
AL
M
KY
S
D
I
H
E
Y
SWAA
PGH
Q
GG
VG
F
T
K
T
P
A
G
R
FYH
D
YY
G
E
N
L
F
R
T
D
M
G
I
ER
T
S
LGSLLDHTG
AF
G
E
S
E
K
Y
A
ARVFGADRS
W
S
V
VV
GTS
G
SN
RTIMQA
C
MT
D
NDV
V
VV
DRNCHKS
I
E
QG
LM
L
T
GA
K
PVY
MV
P
S
RN
R
YGI
I
G
P
I
Y
PQ
E
M
Q
PE
T
L
Q
KK
I
S
E
S
P
LTKDK
A
G
Q
K
P
SYC
V
V
TN
C
TYDG
VC
YN
AK
E
AQ
D
L
L
EK
T
S
DRL
HFD
E
AW
YG
Y
A
R
F
N
PIY
A
DH
Y
A
M
R
GE
--
PGDH
N
G
PTV
F
A
T
H
STHKLL
N
ALSQAS
Y
IHV
REG
-
R
G
AI
N
FS
R
FN
Q
AYMMH
A
TTSP
L
Y
A
I
C
AS
N
DV
A
VS
MM
D
GN
S
G
LS
L
TQ
E
V
I
DE
A
V
D
FR
QA
M
A
---
RL
Y
K
E
F
A
ADGS
WFF
K
P
W
NK
EV
V
T
D
PQTGKTYDFADAPTKLLTTV
Q
D
CW
V
M
H
PGE
S
WHGF
--
KDI
P
D
N
WS
M
LDPIKV
S
IL
A
PGM
G
EDG
E
LE
E
T
G
V
PAALV
TA
W
L
GR
HGIV
PTR
T
TDFQIM
FLFS
M
G
VTRG
K
W
GT
L
VN
T
L
C
S
FKR
H
YD
A
N
TP
L
AQVM
P
E
L
V
E
QY
PD
T
Y
A
NM
G
I
H
DL
GD
T
MFAWL
KE
N
N
PG
A
RL
N
E
A
Y
SG
LP
V
A
E
I
TP
RE
A
Y
N
AI
V
D
N
N
VE
L
V
S
I
E
N
L
P
GRI
A
AN
SVI
PYPPG
I
P
M
L
LS
GE
N
F
G
D
KNS
P
QV
S
Y
L
R
S
L
Q
S
W
D
H
H
F
PGFE
HETE
G
T
EI-I
DG
I
Y
H
V
M
CV
K
fig|502346.5.peg.1540
Escherichia coli O157:H7 str. TW14588 (22-755/756)
V
E
R
L
AD
AL
SQ
QN
VTV
I
K
S
T
S
F
DD
GFA
I
LS
S
N
E
A
I
DCLM
F
SYQ
M
E
H
P
D
EH
Q
N
V
R
QL
IGKLHERQQ
N
V
P
VFLL
G
DR
E
KA
L
AAM
DR
---
DL
L
E
-----
L
V
D
E
F
AWI
L
ED
T
A
DF
IA
G
R
AV
A
A
M
T
R
Y
RQQ
L
LPPL
FS
AL
M
KY
S
D
I
H
E
Y
SWAA
PGH
Q
GG
VG
F
T
K
T
P
A
G
R
FYH
D
YY
G
E
N
L
F
R
T
D
M
G
I
ER
T
S
LGSLLDHTG
AF
G
E
S
E
K
Y
A
ARVFGADRS
W
S
V
VV
GTS
G
SN
RTIMQA
C
MT
D
NDV
V
VV
DRNCHKS
I
E
QG
LM
L
T
GA
K
PVY
MV
P
S
RN
R
YGI
I
G
P
I
Y
PQ
E
M
Q
PE
T
L
Q
KK
I
S
E
S
P
LTKDK
A
G
Q
K
P
SYC
V
V
TN
C
TYDG
VC
YN
AK
E
AQ
D
L
L
EK
T
S
DRL
HFD
E
AW
YG
Y
A
R
F
N
PIY
A
DH
Y
A
M
R
GE
--
PGDH
N
G
PTV
F
A
T
H
STHKLL
N
ALSQAS
Y
IHV
REG
-
R
G
AI
N
FS
R
FN
Q
AYMMH
A
TTSP
L
Y
A
I
C
AS
N
DV
A
VS
MM
D
GN
S
G
LS
L
TQ
E
V
I
DE
A
V
D
FR
QA
M
A
---
RL
Y
K
E
F
A
ADGS
WFF
K
P
W
NK
EV
V
T
D
PQTGKTYDFADAPTKLLTTV
Q
D
CW
V
M
H
PGE
S
WHGF
--
KDI
P
D
N
WS
M
LDPIKV
S
IL
A
PGM
G
EDG
E
LE
E
T
G
V
PAALV
TA
W
L
GR
HGIV
PTR
T
TDFQIM
FLFS
M
G
VTRG
K
W
GT
L
VN
T
L
C
S
FKR
H
YD
A
N
TP
L
AQVM
P
E
L
V
E
QY
PD
T
Y
A
NM
G
I
H
DL
GD
T
MFAWL
KE
N
N
PG
A
RL
N
E
A
Y
SG
LP
V
A
E
I
TP
RE
A
Y
N
AI
V
D
N
N
VE
L
V
S
I
E
N
L
P
GRI
A
AN
SVI
PYPPG
I
P
M
L
LS
GE
N
F
G
D
KNS
P
QV
S
Y
L
R
S
L
Q
S
W
D
H
H
F
PGFE
HETE
G
T
EI-I
DG
I
Y
H
V
M
CV
K
fig|701177.3.peg.4949
Escherichia coli O55:H7 str. CB9615 (22-755/756)
V
E
R
L
AD
AL
SQ
QN
VTV
I
K
S
T
S
F
DD
GFA
I
LS
S
N
E
A
I
DCLM
F
SYQ
M
E
H
P
D
EH
Q
N
V
R
QL
IGKLHERQQ
N
V
P
VFLL
G
DR
E
KA
L
AAM
DR
---
DL
L
E
-----
L
V
D
E
F
AWI
L
ED
T
A
DF
IA
G
R
AV
A
A
M
T
R
Y
RQQ
L
LPPL
FS
AL
M
KY
S
D
I
H
E
Y
SWAA
PGH
Q
GG
VG
F
T
K
T
P
A
G
R
FYH
D
YY
G
E
N
L
F
R
T
D
M
G
I
ER
T
S
LGSLLDHTG
AF
G
E
S
E
K
Y
A
ARVFGADRS
W
S
V
VV
GTS
G
SN
RTIMQA
C
MT
D
NDV
V
VV
DRNCHKS
I
E
QG
LM
L
T
GA
K
PVY
MV
P
S
RN
R
YGI
I
G
P
I
Y
PQ
E
M
Q
PE
T
L
Q
KK
I
S
E
S
P
LTKDK
A
G
Q
K
P
SYC
V
V
TN
C
TYDG
VC
YN
AK
E
AQ
D
L
L
EK
T
S
DRL
HFD
E
AW
YG
Y
A
R
F
N
PIY
A
DH
Y
A
M
R
GE
--
PGDH
N
G
PTV
F
A
T
H
STHKLL
N
ALSQAS
Y
IHV
REG
-
R
G
AI
N
FS
R
FN
Q
AYMMH
A
TTSP
L
Y
A
I
C
AS
N
DV
A
VS
MM
D
GN
S
G
LS
L
TQ
E
V
I
DE
A
V
D
FR
QA
M
A
---
RL
Y
K
E
F
A
ADGS
WFF
K
P
W
NK
EV
V
T
D
PQTGKTYDFADAPTKLLTTV
Q
D
CW
V
M
H
PGE
S
WHGF
--
KDI
P
D
N
WS
M
LDPIKV
S
IL
A
PGM
G
EDG
E
LE
E
T
G
V
PAALV
TA
W
L
GR
HGIV
PTR
T
TDFQIM
FLFS
M
G
VTRG
K
W
GT
L
VN
T
L
C
S
FKR
H
YD
A
N
TP
L
AQVM
P
E
L
V
E
QY
PD
T
Y
A
NM
G
I
H
DL
GD
T
MFAWL
KE
N
N
PG
A
RL
N
E
A
Y
SG
LP
V
A
E
I
TP
RE
A
Y
N
AI
V
D
N
N
VE
L
V
S
I
E
N
L
P
GRI
A
AN
SVI
PYPPG
I
P
M
L
LS
GE
N
F
G
D
KNS
P
QV
S
Y
L
R
S
L
Q
S
W
D
H
H
F
PGFE
HETE
G
T
EI-I
DG
I
Y
H
V
M
CV
K
fig|656444.3.peg.5576
Escherichia coli TA280 (22-755/756)
V
E
R
L
AD
AL
SQ
QN
VTV
I
K
S
T
S
F
DD
GFA
I
LS
S
N
E
A
I
DCLM
F
SYQ
M
E
H
P
D
EH
Q
N
V
R
QL
IGKLHERQQ
N
V
P
VFLL
G
DR
E
KA
L
AAM
DR
---
DL
L
E
-----
L
V
D
E
F
AWI
L
ED
T
A
DF
IA
G
R
AV
A
A
M
T
R
Y
RQQ
L
LPPL
FS
AL
M
KY
S
D
I
H
E
Y
SWAA
PGH
Q
GG
VG
F
T
K
T
P
A
G
R
FYH
D
YY
G
E
N
L
F
R
T
D
M
G
I
ER
T
S
LGSLLDHTG
AF
G
E
S
E
K
Y
A
ARVFGADRS
W
S
V
VV
GTS
G
SN
RTIMQA
C
MT
D
NDV
V
VV
DRNCHKS
I
E
QG
LM
L
T
GA
K
PVY
MV
P
S
RN
R
YGI
I
G
P
I
Y
PQ
E
M
Q
PE
T
L
Q
KK
I
S
E
S
P
LTKDK
A
G
Q
K
P
SYC
V
V
TN
C
TYDG
VC
YN
AK
E
AQ
D
L
L
EK
T
S
DRL
HFD
E
AW
YG
Y
A
R
F
N
PIY
A
DH
Y
A
M
R
GE
--
PGDH
N
G
PTV
F
A
T
H
STHKLL
N
ALSQAS
Y
IHV
REG
-
R
G
AI
N
FS
R
FN
Q
AYMMH
A
TTSP
L
Y
A
I
C
AS
N
DV
A
VS
MM
D
GN
S
G
LS
L
TQ
E
V
I
DE
A
V
D
FR
QA
M
A
---
RL
Y
K
E
FTADGS
WFF
K
P
W
NK
EV
V
T
D
PQTGKTYDFADAPTKLLTTV
Q
D
CW
V
M
H
PGE
S
WHGF
--
KDI
P
D
N
WS
M
LDPIKV
S
IL
A
PGM
G
EDG
E
LE
E
T
G
V
PAALV
TA
W
L
GR
HGIV
PTR
T
TDFQIM
FLFS
M
G
VTRG
K
W
GT
L
VN
T
L
C
S
FKR
H
YD
A
N
TP
L
AQVM
P
E
L
V
E
QY
PD
T
Y
A
NM
G
I
H
DL
GD
T
MFAWL
KE
N
N
PG
A
RL
N
E
A
Y
SG
LP
V
A
E
I
TP
RE
A
Y
N
AI
V
D
N
N
VE
L
V
S
I
E
N
L
P
GRI
A
AN
SVI
PYPPG
I
P
M
L
LS
GE
N
F
G
D
KNS
P
QV
S
Y
L
R
S
L
Q
S
W
D
H
H
F
PGFE
HETE
G
T
EI-I
DG
I
Y
H
V
M
CV
K
fig|585056.7.peg.4813
Escherichia coli UMN026 (22-755/756)
V
E
R
L
AD
AL
SQ
QN
VTV
I
K
S
T
S
F
DD
GFA
I
LS
S
N
E
A
I
DCLM
F
SYQ
M
E
H
P
D
EH
Q
N
V
R
QL
IGKLHERQQ
N
V
P
VFLL
G
DR
E
KA
L
AAM
DR
---
DL
L
E
-----
L
V
D
E
F
AWI
L
ED
T
A
DF
IA
G
R
AV
A
A
M
T
R
Y
RQQ
L
LPPL
FS
AL
M
KY
S
D
I
H
E
Y
SWAA
PGH
Q
GG
VG
F
T
K
T
P
A
G
R
FYH
D
YY
G
E
N
L
F
R
T
D
M
G
I
ER
T
S
LGSLLDHTG
AF
G
E
S
E
K
Y
A
ARVFGADRS
W
S
V
VV
GTS
G
SN
RTIMQA
C
MT
D
NDV
V
VV
DRNCHKS
I
E
QG
LM
L
T
GA
K
PVY
MV
P
S
RN
R
YGI
I
G
P
I
Y
PQ
E
M
Q
PE
T
L
Q
KK
I
S
E
S
P
LTKDK
A
G
Q
K
P
SYC
V
V
TN
C
TYDG
VC
YN
AK
E
AQ
D
L
L
EK
T
S
DRL
HFD
E
AW
YG
Y
A
R
F
N
PIY
A
DH
Y
A
M
R
GE
--
PGDH
N
G
PTV
F
A
T
H
STHKLL
N
ALSQAS
Y
IHV
REG
-
R
G
AI
N
FS
R
FN
Q
AYMMH
A
TTSP
L
Y
A
I
C
AS
N
DV
A
VS
MM
D
GN
S
G
LS
L
TQ
E
V
I
DE
A
V
D
FR
QA
M
A
---
RL
Y
K
E
FTADGS
WFF
K
P
W
NK
EV
V
T
D
PQTGKTYDFADAPTKLLTTV
Q
D
CW
V
M
H
PGE
S
WHGF
--
KDI
P
D
N
WS
M
LDPIKV
S
IL
A
PGM
G
EDG
E
LE
E
T
G
V
PAALV
TA
W
L
GR
HGIV
PTR
T
TDFQIM
FLFS
M
G
VTRG
K
W
GT
L
VN
T
L
C
S
FKR
H
YD
A
N
TP
L
AQVM
P
E
L
V
E
QY
PD
T
Y
A
NM
G
I
H
DL
GD
T
MFAWL
KE
N
N
PG
A
RL
N
E
A
Y
SG
LP
V
A
E
I
TP
RE
A
Y
N
AI
V
D
N
N
VE
L
V
S
I
E
N
L
P
GRI
A
AN
SVI
PYPPG
I
P
M
L
LS
GE
N
F
G
D
KNS
P
QV
S
Y
L
R
S
L
Q
S
W
D
H
H
F
PGFE
HETE
G
T
EI-I
DG
I
Y
H
V
M
CV
K
fig|656419.3.peg.5364
Escherichia coli M718 (22-755/756)
V
E
R
L
AD
AL
SQ
QN
VTV
I
K
S
T
S
F
DD
GFA
I
LS
S
N
E
A
I
DCLM
F
SYQ
M
E
H
P
D
EH
Q
N
V
R
QL
IGKLHERQQ
N
V
P
VFLL
G
DR
E
KA
L
AAM
DR
---
DL
L
E
-----
L
V
D
E
F
AWI
L
ED
T
A
DF
IA
G
R
AV
A
A
M
T
R
Y
RQQ
L
LPPL
FS
AL
M
KY
S
D
I
H
E
Y
SWAA
PGH
Q
GG
VG
F
T
K
T
P
A
G
R
FYH
D
YY
G
E
N
L
F
R
T
D
M
G
I
ER
T
S
LGSLLDHTG
AF
G
E
S
E
K
Y
A
ARVFGADRS
W
S
V
VV
GTS
G
SN
RTIMQA
C
MT
D
NDV
V
VV
DRNCHKS
I
E
QG
LM
L
T
GA
K
PVY
MV
P
S
RN
R
YGI
I
G
P
I
Y
PQ
E
I
Q
PE
T
L
Q
KK
I
S
E
S
P
LTKDK
A
G
Q
K
P
SYC
V
V
TN
C
TYDG
VC
YN
AK
E
AQ
D
L
L
EK
T
S
DRL
HFD
E
AW
YG
Y
A
R
F
N
PIY
A
DH
Y
A
M
R
GE
--
PGDH
N
G
PTV
F
A
T
H
STHKLL
N
ALSQAS
Y
IHV
REG
-
R
G
AI
N
FS
R
FN
Q
AYMMH
A
TTSP
L
Y
A
I
C
AS
N
DV
A
VS
MM
D
GN
S
G
LS
L
TQ
E
V
I
DE
A
V
D
FR
QA
M
A
---
RL
Y
K
E
FTADGS
WFF
K
P
W
NK
EV
V
T
D
PQTGKTYDFADAPTKLLTTV
Q
D
CW
V
M
H
PGE
S
WHGF
--
KDI
P
D
N
WS
M
LDPIKV
S
IL
A
PGM
G
EDG
E
LE
E
T
G
V
PAALV
TA
W
L
GR
HGIV
PTR
T
TDFQIM
FLFS
M
G
VTRG
K
W
GT
L
VN
T
L
C
S
FKR
H
YD
A
N
TP
L
AQVM
P
E
L
V
E
QY
PD
T
Y
A
NM
G
I
H
DL
GD
T
MFAWL
KE
N
N
PG
A
RL
N
E
A
Y
SG
LP
V
A
E
I
TP
RE
A
Y
N
AI
V
D
N
N
VE
L
V
S
I
E
N
L
P
GRI
A
AN
SVI
PYPPG
I
P
M
L
LS
GE
N
F
G
D
KNS
P
QV
S
Y
L
R
S
L
Q
S
W
D
H
H
F
PGFE
HETE
G
T
EI-I
DG
I
Y
H
V
M
CV
K
fig|358709.5.peg.1868
Escherichia coli 101-1 (22-755/756)
V
E
R
L
AD
AL
SQ
QN
VTV
I
K
S
T
S
F
DD
GFA
I
LS
S
N
E
A
I
DCLM
F
SYQ
M
E
H
P
D
EH
Q
N
V
R
QL
IGKLHERQQ
N
V
P
VFLL
G
DR
E
KA
L
AAM
DR
---
DL
L
E
-----
L
V
D
E
F
AWI
L
ED
T
A
DF
IA
G
R
AV
A
A
M
T
R
Y
RQQ
L
LPPL
FS
AL
M
KY
S
D
I
H
E
Y
SWAA
PGH
Q
GG
VG
F
T
K
T
P
A
G
R
FYH
D
YY
G
E
N
L
F
R
T
D
M
G
I
ER
T
S
LGSLLDHTG
AF
G
E
S
E
K
Y
A
ARVFGADRS
W
S
V
VV
GTS
G
SN
RTIMQA
C
MT
D
NDV
V
VV
DRNCHKS
I
E
QG
LM
L
T
GA
K
PVY
MV
P
S
RN
R
YGI
I
G
P
I
Y
PQ
E
M
Q
PE
T
L
Q
KK
I
S
E
S
P
LTKDK
A
G
Q
K
P
SYC
V
V
TN
C
TYDG
VC
YN
AK
E
AQ
D
L
L
EK
T
S
DRL
HFD
E
AW
YG
Y
A
R
F
N
PIY
A
DH
Y
A
M
R
GE
--
PGDH
N
G
PTV
F
A
T
H
STHKLL
N
ALSQAS
Y
IHV
REG
-
R
G
AI
N
FS
R
FN
Q
AYMMH
A
TTSP
L
Y
A
I
C
AS
N
DV
A
VS
MM
D
GN
S
G
LS
L
TQ
E
V
I
DE
A
V
D
FR
QA
M
A
---
RL
Y
K
E
FTADGS
WFF
K
P
W
NK
EV
V
T
D
PQTGKTYDFADAPTKLLTTV
Q
D
CW
V
M
H
PGE
S
WHGF
--
KDI
P
D
N
WS
M
LDPIKV
S
IL
A
PGM
G
EDG
E
LE
E
T
G
V
PAALV
TA
W
L
GR
HGIV
PTR
T
TDFQIM
FLFS
M
G
VTRG
K
W
GT
L
VN
T
L
C
S
FKR
H
YD
A
N
TP
L
AQVM
P
E
L
V
E
QY
PD
T
Y
A
NM
G
I
H
DL
GD
T
MFAWL
KE
N
N
PG
A
RL
N
E
A
Y
SG
LP
V
A
E
V
TP
RE
A
Y
N
AI
V
D
N
N
VE
L
V
S
I
E
N
L
P
GRI
A
AN
SVI
PYPPG
I
P
M
L
LS
GE
N
F
G
D
KNS
P
QV
S
Y
L
R
S
L
Q
S
W
D
H
H
F
PGFE
HETE
G
T
EI-I
DG
I
Y
H
V
M
CV
K
fig|670888.3.peg.4619
Escherichia coli 1827-70 (22-755/756)
V
E
R
L
AD
AL
SQ
QN
VTV
I
K
S
T
S
F
DD
GFA
I
LS
S
N
E
A
I
DCLM
F
SYQ
M
E
H
P
D
EH
Q
N
V
R
QL
IGKLHERQQ
N
V
P
VFLL
G
DR
E
KA
L
AAM
DR
---
DL
L
E
-----
L
V
D
E
F
AWI
L
ED
T
A
DF
IA
G
R
AV
A
A
M
T
R
Y
RQQ
L
LPPL
FS
AL
M
KY
S
D
I
H
E
Y
SWAA
PGH
Q
GG
VG
F
T
K
T
P
A
G
R
FYH
D
YY
G
E
N
L
F
R
T
D
M
G
I
ER
T
S
LGSLLDHTG
AF
G
E
S
E
K
Y
A
ARVFGADRS
W
S
V
VV
GTS
G
SN
RTIMQA
C
MT
D
NDV
V
VV
DRNCHKS
I
E
QG
LM
L
T
GA
K
PVY
MV
P
S
RN
R
YGI
I
G
P
I
Y
PQ
E
M
Q
PE
T
L
Q
KK
I
S
E
S
P
LTKDK
A
G
Q
K
P
SYC
V
V
TN
C
TYDG
VC
YN
AK
E
AQ
D
L
L
EK
T
S
DRL
HFD
E
AW
YG
Y
A
R
F
N
PIY
A
DH
Y
A
M
R
GE
--
PGDH
N
G
PTV
F
A
T
H
STHKLL
N
ALSQAS
Y
IHV
REG
-
R
G
AI
N
FS
R
FN
Q
AYMMH
A
TTSP
L
Y
A
I
C
AS
N
DV
A
VS
MM
D
GN
S
G
LS
L
TQ
E
V
I
DE
A
V
D
FR
QA
M
A
---
RL
Y
K
E
FTADGS
WFF
K
P
W
NK
EV
V
T
D
PQTGKTYDFADAPTKLLTTV
Q
D
CW
V
M
H
PGE
S
WHGF
--
KDI
P
D
N
WS
M
LDPIKV
S
IL
A
PGM
G
EDG
E
LE
E
T
G
V
PAALV
TA
W
L
GR
HGIV
PTR
T
TDFQIM
FLFS
M
G
VTRG
K
W
GT
L
VN
T
L
C
S
FKR
H
YD
A
N
TP
L
AQVM
P
E
L
V
E
QY
PD
T
Y
A
NM
G
I
H
DL
GD
T
MFAWL
KE
N
N
PG
A
RL
N
E
A
Y
SG
LP
V
A
E
V
TP
RE
A
Y
N
AI
V
D
N
N
VE
L
V
S
I
E
N
L
P
GRI
A
AN
SVI
PYPPG
I
P
M
L
LS
GE
N
F
G
D
KNS
P
QV
S
Y
L
R
S
L
Q
S
W
D
H
H
F
PGFE
HETE
G
T
EI-I
DG
I
Y
H
V
M
CV
K
fig|595496.3.peg.4192
Escherichia coli BW2952 (22-755/756)
V
E
R
L
AD
AL
SQ
QN
VTV
I
K
S
T
S
F
DD
GFA
I
LS
S
N
E
A
I
DCLM
F
SYQ
M
E
H
P
D
EH
Q
N
V
R
QL
IGKLHERQQ
N
V
P
VFLL
G
DR
E
KA
L
AAM
DR
---
DL
L
E
-----
L
V
D
E
F
AWI
L
ED
T
A
DF
IA
G
R
AV
A
A
M
T
R
Y
RQQ
L
LPPL
FS
AL
M
KY
S
D
I
H
E
Y
SWAA
PGH
Q
GG
VG
F
T
K
T
P
A
G
R
FYH
D
YY
G
E
N
L
F
R
T
D
M
G
I
ER
T
S
LGSLLDHTG
AF
G
E
S
E
K
Y
A
ARVFGADRS
W
S
V
VV
GTS
G
SN
RTIMQA
C
MT
D
NDV
V
VV
DRNCHKS
I
E
QG
LM
L
T
GA
K
PVY
MV
P
S
RN
R
YGI
I
G
P
I
Y
PQ
E
M
Q
PE
T
L
Q
KK
I
S
E
S
P
LTKDK
A
G
Q
K
P
SYC
V
V
TN
C
TYDG
VC
YN
AK
E
AQ
D
L
L
EK
T
S
DRL
HFD
E
AW
YG
Y
A
R
F
N
PIY
A
DH
Y
A
M
R
GE
--
PGDH
N
G
PTV
F
A
T
H
STHKLL
N
ALSQAS
Y
IHV
REG
-
R
G
AI
N
FS
R
FN
Q
AYMMH
A
TTSP
L
Y
A
I
C
AS
N
DV
A
VS
MM
D
GN
S
G
LS
L
TQ
E
V
I
DE
A
V
D
FR
QA
M
A
---
RL
Y
K
E
FTADGS
WFF
K
P
W
NK
EV
V
T
D
PQTGKTYDFADAPTKLLTTV
Q
D
CW
V
M
H
PGE
S
WHGF
--
KDI
P
D
N
WS
M
LDPIKV
S
IL
A
PGM
G
EDG
E
LE
E
T
G
V
PAALV
TA
W
L
GR
HGIV
PTR
T
TDFQIM
FLFS
M
G
VTRG
K
W
GT
L
VN
T
L
C
S
FKR
H
YD
A
N
TP
L
AQVM
P
E
L
V
E
QY
PD
T
Y
A
NM
G
I
H
DL
GD
T
MFAWL
KE
N
N
PG
A
RL
N
E
A
Y
SG
LP
V
A
E
V
TP
RE
A
Y
N
AI
V
D
N
N
VE
L
V
S
I
E
N
L
P
GRI
A
AN
SVI
PYPPG
I
P
M
L
LS
GE
N
F
G
D
KNS
P
QV
S
Y
L
R
S
L
Q
S
W
D
H
H
F
PGFE
HETE
G
T
EI-I
DG
I
Y
H
V
M
CV
K
fig|536056.3.peg.4114
Escherichia coli DH1 (22-755/756)
V
E
R
L
AD
AL
SQ
QN
VTV
I
K
S
T
S
F
DD
GFA
I
LS
S
N
E
A
I
DCLM
F
SYQ
M
E
H
P
D
EH
Q
N
V
R
QL
IGKLHERQQ
N
V
P
VFLL
G
DR
E
KA
L
AAM
DR
---
DL
L
E
-----
L
V
D
E
F
AWI
L
ED
T
A
DF
IA
G
R
AV
A
A
M
T
R
Y
RQQ
L
LPPL
FS
AL
M
KY
S
D
I
H
E
Y
SWAA
PGH
Q
GG
VG
F
T
K
T
P
A
G
R
FYH
D
YY
G
E
N
L
F
R
T
D
M
G
I
ER
T
S
LGSLLDHTG
AF
G
E
S
E
K
Y
A
ARVFGADRS
W
S
V
VV
GTS
G
SN
RTIMQA
C
MT
D
NDV
V
VV
DRNCHKS
I
E
QG
LM
L
T
GA
K
PVY
MV
P
S
RN
R
YGI
I
G
P
I
Y
PQ
E
M
Q
PE
T
L
Q
KK
I
S
E
S
P
LTKDK
A
G
Q
K
P
SYC
V
V
TN
C
TYDG
VC
YN
AK
E
AQ
D
L
L
EK
T
S
DRL
HFD
E
AW
YG
Y
A
R
F
N
PIY
A
DH
Y
A
M
R
GE
--
PGDH
N
G
PTV
F
A
T
H
STHKLL
N
ALSQAS
Y
IHV
REG
-
R
G
AI
N
FS
R
FN
Q
AYMMH
A
TTSP
L
Y
A
I
C
AS
N
DV
A
VS
MM
D
GN
S
G
LS
L
TQ
E
V
I
DE
A
V
D
FR
QA
M
A
---
RL
Y
K
E
FTADGS
WFF
K
P
W
NK
EV
V
T
D
PQTGKTYDFADAPTKLLTTV
Q
D
CW
V
M
H
PGE
S
WHGF
--
KDI
P
D
N
WS
M
LDPIKV
S
IL
A
PGM
G
EDG
E
LE
E
T
G
V
PAALV
TA
W
L
GR
HGIV
PTR
T
TDFQIM
FLFS
M
G
VTRG
K
W
GT
L
VN
T
L
C
S
FKR
H
YD
A
N
TP
L
AQVM
P
E
L
V
E
QY
PD
T
Y
A
NM
G
I
H
DL
GD
T
MFAWL
KE
N
N
PG
A
RL
N
E
A
Y
SG
LP
V
A
E
V
TP
RE
A
Y
N
AI
V
D
N
N
VE
L
V
S
I
E
N
L
P
GRI
A
AN
SVI
PYPPG
I
P
M
L
LS
GE
N
F
G
D
KNS
P
QV
S
Y
L
R
S
L
Q
S
W
D
H
H
F
PGFE
HETE
G
T
EI-I
DG
I
Y
H
V
M
CV
K
fig|316401.4.peg.5029
Escherichia coli ETEC H10407 (22-755/756)
V
E
R
L
AD
AL
SQ
QN
VTV
I
K
S
T
S
F
DD
GFA
I
LS
S
N
E
A
I
DCLM
F
SYQ
M
E
H
P
D
EH
Q
N
V
R
QL
IGKLHERQQ
N
V
P
VFLL
G
DR
E
KA
L
AAM
DR
---
DL
L
E
-----
L
V
D
E
F
AWI
L
ED
T
A
DF
IA
G
R
AV
A
A
M
T
R
Y
RQQ
L
LPPL
FS
AL
M
KY
S
D
I
H
E
Y
SWAA
PGH
Q
GG
VG
F
T
K
T
P
A
G
R
FYH
D
YY
G
E
N
L
F
R
T
D
M
G
I
ER
T
S
LGSLLDHTG
AF
G
E
S
E
K
Y
A
ARVFGADRS
W
S
V
VV
GTS
G
SN
RTIMQA
C
MT
D
NDV
V
VV
DRNCHKS
I
E
QG
LM
L
T
GA
K
PVY
MV
P
S
RN
R
YGI
I
G
P
I
Y
PQ
E
M
Q
PE
T
L
Q
KK
I
S
E
S
P
LTKDK
A
G
Q
K
P
SYC
V
V
TN
C
TYDG
VC
YN
AK
E
AQ
D
L
L
EK
T
S
DRL
HFD
E
AW
YG
Y
A
R
F
N
PIY
A
DH
Y
A
M
R
GE
--
PGDH
N
G
PTV
F
A
T
H
STHKLL
N
ALSQAS
Y
IHV
REG
-
R
G
AI
N
FS
R
FN
Q
AYMMH
A
TTSP
L
Y
A
I
C
AS
N
DV
A
VS
MM
D
GN
S
G
LS
L
TQ
E
V
I
DE
A
V
D
FR
QA
M
A
---
RL
Y
K
E
FTADGS
WFF
K
P
W
NK
EV
V
T
D
PQTGKTYDFADAPTKLLTTV
Q
D
CW
V
M
H
PGE
S
WHGF
--
KDI
P
D
N
WS
M
LDPIKV
S
IL
A
PGM
G
EDG
E
LE
E
T
G
V
PAALV
TA
W
L
GR
HGIV
PTR
T
TDFQIM
FLFS
M
G
VTRG
K
W
GT
L
VN
T
L
C
S
FKR
H
YD
A
N
TP
L
AQVM
P
E
L
V
E
QY
PD
T
Y
A
NM
G
I
H
DL
GD
T
MFAWL
KE
N
N
PG
A
RL
N
E
A
Y
SG
LP
V
A
E
V
TP
RE
A
Y
N
AI
V
D
N
N
VE
L
V
S
I
E
N
L
P
GRI
A
AN
SVI
PYPPG
I
P
M
L
LS
GE
N
F
G
D
KNS
P
QV
S
Y
L
R
S
L
Q
S
W
D
H
H
F
PGFE
HETE
G
T
EI-I
DG
I
Y
H
V
M
CV
K
fig|83333.1.peg.4029
Escherichia coli K12 (22-755/756)
V
E
R
L
AD
AL
SQ
QN
VTV
I
K
S
T
S
F
DD
GFA
I
LS
S
N
E
A
I
DCLM
F
SYQ
M
E
H
P
D
EH
Q
N
V
R
QL
IGKLHERQQ
N
V
P
VFLL
G
DR
E
KA
L
AAM
DR
---
DL
L
E
-----
L
V
D
E
F
AWI
L
ED
T
A
DF
IA
G
R
AV
A
A
M
T
R
Y
RQQ
L
LPPL
FS
AL
M
KY
S
D
I
H
E
Y
SWAA
PGH
Q
GG
VG
F
T
K
T
P
A
G
R
FYH
D
YY
G
E
N
L
F
R
T
D
M
G
I
ER
T
S
LGSLLDHTG
AF
G
E
S
E
K
Y
A
ARVFGADRS
W
S
V
VV
GTS
G
SN
RTIMQA
C
MT
D
NDV
V
VV
DRNCHKS
I
E
QG
LM
L
T
GA
K
PVY
MV
P
S
RN
R
YGI
I
G
P
I
Y
PQ
E
M
Q
PE
T
L
Q
KK
I
S
E
S
P
LTKDK
A
G
Q
K
P
SYC
V
V
TN
C
TYDG
VC
YN
AK
E
AQ
D
L
L
EK
T
S
DRL
HFD
E
AW
YG
Y
A
R
F
N
PIY
A
DH
Y
A
M
R
GE
--
PGDH
N
G
PTV
F
A
T
H
STHKLL
N
ALSQAS
Y
IHV
REG
-
R
G
AI
N
FS
R
FN
Q
AYMMH
A
TTSP
L
Y
A
I
C
AS
N
DV
A
VS
MM
D
GN
S
G
LS
L
TQ
E
V
I
DE
A
V
D
FR
QA
M
A
---
RL
Y
K
E
FTADGS
WFF
K
P
W
NK
EV
V
T
D
PQTGKTYDFADAPTKLLTTV
Q
D
CW
V
M
H
PGE
S
WHGF
--
KDI
P
D
N
WS
M
LDPIKV
S
IL
A
PGM
G
EDG
E
LE
E
T
G
V
PAALV
TA
W
L
GR
HGIV
PTR
T
TDFQIM
FLFS
M
G
VTRG
K
W
GT
L
VN
T
L
C
S
FKR
H
YD
A
N
TP
L
AQVM
P
E
L
V
E
QY
PD
T
Y
A
NM
G
I
H
DL
GD
T
MFAWL
KE
N
N
PG
A
RL
N
E
A
Y
SG
LP
V
A
E
V
TP
RE
A
Y
N
AI
V
D
N
N
VE
L
V
S
I
E
N
L
P
GRI
A
AN
SVI
PYPPG
I
P
M
L
LS
GE
N
F
G
D
KNS
P
QV
S
Y
L
R
S
L
Q
S
W
D
H
H
F
PGFE
HETE
G
T
EI-I
DG
I
Y
H
V
M
CV
K
fig|595495.4.peg.4122
Escherichia coli KO11 (22-755/756)
V
E
R
L
AD
AL
SQ
QN
VTV
I
K
S
T
S
F
DD
GFA
I
LS
S
N
E
A
I
DCLM
F
SYQ
M
E
H
P
D
EH
Q
N
V
R
QL
IGKLHERQQ
N
V
P
VFLL
G
DR
E
KA
L
AAM
DR
---
DL
L
E
-----
L
V
D
E
F
AWI
L
ED
T
A
DF
IA
G
R
AV
A
A
M
T
R
Y
RQQ
L
LPPL
FS
AL
M
KY
S
D
I
H
E
Y
SWAA
PGH
Q
GG
VG
F
T
K
T
P
A
G
R
FYH
D
YY
G
E
N
L
F
R
T
D
M
G
I
ER
T
S
LGSLLDHTG
AF
G
E
S
E
K
Y
A
ARVFGADRS
W
S
V
VV
GTS
G
SN
RTIMQA
C
MT
D
NDV
V
VV
DRNCHKS
I
E
QG
LM
L
T
GA
K
PVY
MV
P
S
RN
R
YGI
I
G
P
I
Y
PQ
E
M
Q
PE
T
L
Q
KK
I
S
E
S
P
LTKDK
A
G
Q
K
P
SYC
V
V
TN
C
TYDG
VC
YN
AK
E
AQ
D
L
L
EK
T
S
DRL
HFD
E
AW
YG
Y
A
R
F
N
PIY
A
DH
Y
A
M
R
GE
--
PGDH
N
G
PTV
F
A
T
H
STHKLL
N
ALSQAS
Y
IHV
REG
-
R
G
AI
N
FS
R
FN
Q
AYMMH
A
TTSP
L
Y
A
I
C
AS
N
DV
A
VS
MM
D
GN
S
G
LS
L
TQ
E
V
I
DE
A
V
D
FR
QA
M
A
---
RL
Y
K
E
FTADGS
WFF
K
P
W
NK
EV
V
T
D
PQTGKTYDFADAPTKLLTTV
Q
D
CW
V
M
H
PGE
S
WHGF
--
KDI
P
D
N
WS
M
LDPIKV
S
IL
A
PGM
G
EDG
E
LE
E
T
G
V
PAALV
TA
W
L
GR
HGIV
PTR
T
TDFQIM
FLFS
M
G
VTRG
K
W
GT
L
VN
T
L
C
S
FKR
H
YD
A
N
TP
L
AQVM
P
E
L
V
E
QY
PD
T
Y
A
NM
G
I
H
DL
GD
T
MFAWL
KE
N
N
PG
A
RL
N
E
A
Y
SG
LP
V
A
E
V
TP
RE
A
Y
N
AI
V
D
N
N
VE
L
V
S
I
E
N
L
P
GRI
A
AN
SVI
PYPPG
I
P
M
L
LS
GE
N
F
G
D
KNS
P
QV
S
Y
L
R
S
L
Q
S
W
D
H
H
F
PGFE
HETE
G
T
EI-I
DG
I
Y
H
V
M
CV
K
fig|749538.3.peg.1249
Escherichia coli MS 116-1 (22-755/756)
V
E
R
L
AD
AL
SQ
QN
VTV
I
K
S
T
S
F
DD
GFA
I
LS
S
N
E
A
I
DCLM
F
SYQ
M
E
H
P
D
EH
Q
N
V
R
QL
IGKLHERQQ
N
V
P
VFLL
G
DR
E
KA
L
AAM
DR
---
DL
L
E
-----
L
V
D
E
F
AWI
L
ED
T
A
DF
IA
G
R
AV
A
A
M
T
R
Y
RQQ
L
LPPL
FS
AL
M
KY
S
D
I
H
E
Y
SWAA
PGH
Q
GG
VG
F
T
K
T
P
A
G
R
FYH
D
YY
G
E
N
L
F
R
T
D
M
G
I
ER
T
S
LGSLLDHTG
AF
G
E
S
E
K
Y
A
ARVFGADRS
W
S
V
VV
GTS
G
SN
RTIMQA
C
MT
D
NDV
V
VV
DRNCHKS
I
E
QG
LM
L
T
GA
K
PVY
MV
P
S
RN
R
YGI
I
G
P
I
Y
PQ
E
M
Q
PE
T
L
Q
KK
I
S
E
S
P
LTKDK
A
G
Q
K
P
SYC
V
V
TN
C
TYDG
VC
YN
AK
E
AQ
D
L
L
EK
T
S
DRL
HFD
E
AW
YG
Y
A
R
F
N
PIY
A
DH
Y
A
M
R
GE
--
PGDH
N
G
PTV
F
A
T
H
STHKLL
N
ALSQAS
Y
IHV
REG
-
R
G
AI
N
FS
R
FN
Q
AYMMH
A
TTSP
L
Y
A
I
C
AS
N
DV
A
VS
MM
D
GN
S
G
LS
L
TQ
E
V
I
DE
A
V
D
FR
QA
M
A
---
RL
Y
K
E
FTADGS
WFF
K
P
W
NK
EV
V
T
D
PQTGKTYDFADAPTKLLTTV
Q
D
CW
V
M
H
PGE
S
WHGF
--
KDI
P
D
N
WS
M
LDPIKV
S
IL
A
PGM
G
EDG
E
LE
E
T
G
V
PAALV
TA
W
L
GR
HGIV
PTR
T
TDFQIM
FLFS
M
G
VTRG
K
W
GT
L
VN
T
L
C
S
FKR
H
YD
A
N
TP
L
AQVM
P
E
L
V
E
QY
PD
T
Y
A
NM
G
I
H
DL
GD
T
MFAWL
KE
N
N
PG
A
RL
N
E
A
Y
SG
LP
V
A
E
V
TP
RE
A
Y
N
AI
V
D
N
N
VE
L
V
S
I
E
N
L
P
GRI
A
AN
SVI
PYPPG
I
P
M
L
LS
GE
N
F
G
D
KNS
P
QV
S
Y
L
R
S
L
Q
S
W
D
H
H
F
PGFE
HETE
G
T
EI-I
DG
I
Y
H
V
M
CV
K
fig|749540.3.peg.1305
Escherichia coli MS 146-1 (22-755/756)
V
E
R
L
AD
AL
SQ
QN
VTV
I
K
S
T
S
F
DD
GFA
I
LS
S
N
E
A
I
DCLM
F
SYQ
M
E
H
P
D
EH
Q
N
V
R
QL
IGKLHERQQ
N
V
P
VFLL
G
DR
E
KA
L
AAM
DR
---
DL
L
E
-----
L
V
D
E
F
AWI
L
ED
T
A
DF
IA
G
R
AV
A
A
M
T
R
Y
RQQ
L
LPPL
FS
AL
M
KY
S
D
I
H
E
Y
SWAA
PGH
Q
GG
VG
F
T
K
T
P
A
G
R
FYH
D
YY
G
E
N
L
F
R
T
D
M
G
I
ER
T
S
LGSLLDHTG
AF
G
E
S
E
K
Y
A
ARVFGADRS
W
S
V
VV
GTS
G
SN
RTIMQA
C
MT
D
NDV
V
VV
DRNCHKS
I
E
QG
LM
L
T
GA
K
PVY
MV
P
S
RN
R
YGI
I
G
P
I
Y
PQ
E
M
Q
PE
T
L
Q
KK
I
S
E
S
P
LTKDK
A
G
Q
K
P
SYC
V
V
TN
C
TYDG
VC
YN
AK
E
AQ
D
L
L
EK
T
S
DRL
HFD
E
AW
YG
Y
A
R
F
N
PIY
A
DH
Y
A
M
R
GE
--
PGDH
N
G
PTV
F
A
T
H
STHKLL
N
ALSQAS
Y
IHV
REG
-
R
G
AI
N
FS
R
FN
Q
AYMMH
A
TTSP
L
Y
A
I
C
AS
N
DV
A
VS
MM
D
GN
S
G
LS
L
TQ
E
V
I
DE
A
V
D
FR
QA
M
A
---
RL
Y
K
E
FTADGS
WFF
K
P
W
NK
EV
V
T
D
PQTGKTYDFADAPTKLLTTV
Q
D
CW
V
M
H
PGE
S
WHGF
--
KDI
P
D
N
WS
M
LDPIKV
S
IL
A
PGM
G
EDG
E
LE
E
T
G
V
PAALV
TA
W
L
GR
HGIV
PTR
T
TDFQIM
FLFS
M
G
VTRG
K
W
GT
L
VN
T
L
C
S
FKR
H
YD
A
N
TP
L
AQVM
P
E
L
V
E
QY
PD
T
Y
A
NM
G
I
H
DL
GD
T
MFAWL
KE
N
N
PG
A
RL
N
E
A
Y
SG
LP
V
A
E
V
TP
RE
A
Y
N
AI
V
D
N
N
VE
L
V
S
I
E
N
L
P
GRI
A
AN
SVI
PYPPG
I
P
M
L
LS
GE
N
F
G
D
KNS
P
QV
S
Y
L
R
S
L
Q
S
W
D
H
H
F
PGFE
HETE
G
T
EI-I
DG
I
Y
H
V
M
CV
K
fig|749544.3.peg.100
Escherichia coli MS 175-1 (22-755/756)
V
E
R
L
AD
AL
SQ
QN
VTV
I
K
S
T
S
F
DD
GFA
I
LS
S
N
E
A
I
DCLM
F
SYQ
M
E
H
P
D
EH
Q
N
V
R
QL
IGKLHERQQ
N
V
P
VFLL
G
DR
E
KA
L
AAM
DR
---
DL
L
E
-----
L
V
D
E
F
AWI
L
ED
T
A
DF
IA
G
R
AV
A
A
M
T
R
Y
RQQ
L
LPPL
FS
AL
M
KY
S
D
I
H
E
Y
SWAA
PGH
Q
GG
VG
F
T
K
T
P
A
G
R
FYH
D
YY
G
E
N
L
F
R
T
D
M
G
I
ER
T
S
LGSLLDHTG
AF
G
E
S
E
K
Y
A
ARVFGADRS
W
S
V
VV
GTS
G
SN
RTIMQA
C
MT
D
NDV
V
VV
DRNCHKS
I
E
QG
LM
L
T
GA
K
PVY
MV
P
S
RN
R
YGI
I
G
P
I
Y
PQ
E
M
Q
PE
T
L
Q
KK
I
S
E
S
P
LTKDK
A
G
Q
K
P
SYC
V
V
TN
C
TYDG
VC
YN
AK
E
AQ
D
L
L
EK
T
S
DRL
HFD
E
AW
YG
Y
A
R
F
N
PIY
A
DH
Y
A
M
R
GE
--
PGDH
N
G
PTV
F
A
T
H
STHKLL
N
ALSQAS
Y
IHV
REG
-
R
G
AI
N
FS
R
FN
Q
AYMMH
A
TTSP
L
Y
A
I
C
AS
N
DV
A
VS
MM
D
GN
S
G
LS
L
TQ
E
V
I
DE
A
V
D
FR
QA
M
A
---
RL
Y
K
E
FTADGS
WFF
K
P
W
NK
EV
V
T
D
PQTGKTYDFADAPTKLLTTV
Q
D
CW
V
M
H
PGE
S
WHGF
--
KDI
P
D
N
WS
M
LDPIKV
S
IL
A
PGM
G
EDG
E
LE
E
T
G
V
PAALV
TA
W
L
GR
HGIV
PTR
T
TDFQIM
FLFS
M
G
VTRG
K
W
GT
L
VN
T
L
C
S
FKR
H
YD
A
N
TP
L
AQVM
P
E
L
V
E
QY
PD
T
Y
A
NM
G
I
H
DL
GD
T
MFAWL
KE
N
N
PG
A
RL
N
E
A
Y
SG
LP
V
A
E
V
TP
RE
A
Y
N
AI
V
D
N
N
VE
L
V
S
I
E
N
L
P
GRI
A
AN
SVI
PYPPG
I
P
M
L
LS
GE
N
F
G
D
KNS
P
QV
S
Y
L
R
S
L
Q
S
W
D
H
H
F
PGFE
HETE
G
T
EI-I
DG
I
Y
H
V
M
CV
K
fig|585395.4.peg.5113
Escherichia coli O103:H2 str. 12009 (22-755/756)
V
E
R
L
AD
AL
SQ
QN
VTV
I
K
S
T
S
F
DD
GFA
I
LS
S
N
E
A
I
DCLM
F
SYQ
M
E
H
P
D
EH
Q
N
V
R
QL
IGKLHERQQ
N
V
P
VFLL
G
DR
E
KA
L
AAM
DR
---
DL
L
E
-----
L
V
D
E
F
AWI
L
ED
T
A
DF
IA
G
R
AV
A
A
M
T
R
Y
RQQ
L
LPPL
FS
AL
M
KY
S
D
I
H
E
Y
SWAA
PGH
Q
GG
VG
F
T
K
T
P
A
G
R
FYH
D
YY
G
E
N
L
F
R
T
D
M
G
I
ER
T
S
LGSLLDHTG
AF
G
E
S
E
K
Y
A
ARVFGADRS
W
S
V
VV
GTS
G
SN
RTIMQA
C
MT
D
NDV
V
VV
DRNCHKS
I
E
QG
LM
L
T
GA
K
PVY
MV
P
S
RN
R
YGI
I
G
P
I
Y
PQ
E
M
Q
PE
T
L
Q
KK
I
S
E
S
P
LTKDK
A
G
Q
K
P
SYC
V
V
TN
C
TYDG
VC
YN
AK
E
AQ
D
L
L
EK
T
S
DRL
HFD
E
AW
YG
Y
A
R
F
N
PIY
A
DH
Y
A
M
R
GE
--
PGDH
N
G
PTV
F
A
T
H
STHKLL
N
ALSQAS
Y
IHV
REG
-
R
G
AI
N
FS
R
FN
Q
AYMMH
A
TTSP
L
Y
A
I
C
AS
N
DV
A
VS
MM
D
GN
S
G
LS
L
TQ
E
V
I
DE
A
V
D
FR
QA
M
A
---
RL
Y
K
E
FTADGS
WFF
K
P
W
NK
EV
V
T
D
PQTGKTYDFADAPTKLLTTV
Q
D
CW
V
M
H
PGE
S
WHGF
--
KDI
P
D
N
WS
M
LDPIKV
S
IL
A
PGM
G
EDG
E
LE
E
T
G
V
PAALV
TA
W
L
GR
HGIV
PTR
T
TDFQIM
FLFS
M
G
VTRG
K
W
GT
L
VN
T
L
C
S
FKR
H
YD
A
N
TP
L
AQVM
P
E
L
V
E
QY
PD
T
Y
A
NM
G
I
H
DL
GD
T
MFAWL
KE
N
N
PG
A
RL
N
E
A
Y
SG
LP
V
A
E
V
TP
RE
A
Y
N
AI
V
D
N
N
VE
L
V
S
I
E
N
L
P
GRI
A
AN
SVI
PYPPG
I
P
M
L
LS
GE
N
F
G
D
KNS
P
QV
S
Y
L
R
S
L
Q
S
W
D
H
H
F
PGFE
HETE
G
T
EI-I
DG
I
Y
H
V
M
CV
K
fig|316407.3.peg.3954
Escherichia coli W3110 (22-755/756)
V
E
R
L
AD
AL
SQ
QN
VTV
I
K
S
T
S
F
DD
GFA
I
LS
S
N
E
A
I
DCLM
F
SYQ
M
E
H
P
D
EH
Q
N
V
R
QL
IGKLHERQQ
N
V
P
VFLL
G
DR
E
KA
L
AAM
DR
---
DL
L
E
-----
L
V
D
E
F
AWI
L
ED
T
A
DF
IA
G
R
AV
A
A
M
T
R
Y
RQQ
L
LPPL
FS
AL
M
KY
S
D
I
H
E
Y
SWAA
PGH
Q
GG
VG
F
T
K
T
P
A
G
R
FYH
D
YY
G
E
N
L
F
R
T
D
M
G
I
ER
T
S
LGSLLDHTG
AF
G
E
S
E
K
Y
A
ARVFGADRS
W
S
V
VV
GTS
G
SN
RTIMQA
C
MT
D
NDV
V
VV
DRNCHKS
I
E
QG
LM
L
T
GA
K
PVY
MV
P
S
RN
R
YGI
I
G
P
I
Y
PQ
E
M
Q
PE
T
L
Q
KK
I
S
E
S
P
LTKDK
A
G
Q
K
P
SYC
V
V
TN
C
TYDG
VC
YN
AK
E
AQ
D
L
L
EK
T
S
DRL
HFD
E
AW
YG
Y
A
R
F
N
PIY
A
DH
Y
A
M
R
GE
--
PGDH
N
G
PTV
F
A
T
H
STHKLL
N
ALSQAS
Y
IHV
REG
-
R
G
AI
N
FS
R
FN
Q
AYMMH
A
TTSP
L
Y
A
I
C
AS
N
DV
A
VS
MM
D
GN
S
G
LS
L
TQ
E
V
I
DE
A
V
D
FR
QA
M
A
---
RL
Y
K
E
FTADGS
WFF
K
P
W
NK
EV
V
T
D
PQTGKTYDFADAPTKLLTTV
Q
D
CW
V
M
H
PGE
S
WHGF
--
KDI
P
D
N
WS
M
LDPIKV
S
IL
A
PGM
G
EDG
E
LE
E
T
G
V
PAALV
TA
W
L
GR
HGIV
PTR
T
TDFQIM
FLFS
M
G
VTRG
K
W
GT
L
VN
T
L
C
S
FKR
H
YD
A
N
TP
L
AQVM
P
E
L
V
E
QY
PD
T
Y
A
NM
G
I
H
DL
GD
T
MFAWL
KE
N
N
PG
A
RL
N
E
A
Y
SG
LP
V
A
E
V
TP
RE
A
Y
N
AI
V
D
N
N
VE
L
V
S
I
E
N
L
P
GRI
A
AN
SVI
PYPPG
I
P
M
L
LS
GE
N
F
G
D
KNS
P
QV
S
Y
L
R
S
L
Q
S
W
D
H
H
F
PGFE
HETE
G
T
EI-I
DG
I
Y
H
V
M
CV
K
fig|511145.12.peg.4248
Escherichia coli str. K-12 substr. MG1655 (22-755/756)
V
E
R
L
AD
AL
SQ
QN
VTV
I
K
S
T
S
F
DD
GFA
I
LS
S
N
E
A
I
DCLM
F
SYQ
M
E
H
P
D
EH
Q
N
V
R
QL
IGKLHERQQ
N
V
P
VFLL
G
DR
E
KA
L
AAM
DR
---
DL
L
E
-----
L
V
D
E
F
AWI
L
ED
T
A
DF
IA
G
R
AV
A
A
M
T
R
Y
RQQ
L
LPPL
FS
AL
M
KY
S
D
I
H
E
Y
SWAA
PGH
Q
GG
VG
F
T
K
T
P
A
G
R
FYH
D
YY
G
E
N
L
F
R
T
D
M
G
I
ER
T
S
LGSLLDHTG
AF
G
E
S
E
K
Y
A
ARVFGADRS
W
S
V
VV
GTS
G
SN
RTIMQA
C
MT
D
NDV
V
VV
DRNCHKS
I
E
QG
LM
L
T
GA
K
PVY
MV
P
S
RN
R
YGI
I
G
P
I
Y
PQ
E
M
Q
PE
T
L
Q
KK
I
S
E
S
P
LTKDK
A
G
Q
K
P
SYC
V
V
TN
C
TYDG
VC
YN
AK
E
AQ
D
L
L
EK
T
S
DRL
HFD
E
AW
YG
Y
A
R
F
N
PIY
A
DH
Y
A
M
R
GE
--
PGDH
N
G
PTV
F
A
T
H
STHKLL
N
ALSQAS
Y
IHV
REG
-
R
G
AI
N
FS
R
FN
Q
AYMMH
A
TTSP
L
Y
A
I
C
AS
N
DV
A
VS
MM
D
GN
S
G
LS
L
TQ
E
V
I
DE
A
V
D
FR
QA
M
A
---
RL
Y
K
E
FTADGS
WFF
K
P
W
NK
EV
V
T
D
PQTGKTYDFADAPTKLLTTV
Q
D
CW
V
M
H
PGE
S
WHGF
--
KDI
P
D
N
WS
M
LDPIKV
S
IL
A
PGM
G
EDG
E
LE
E
T
G
V
PAALV
TA
W
L
GR
HGIV
PTR
T
TDFQIM
FLFS
M
G
VTRG
K
W
GT
L
VN
T
L
C
S
FKR
H
YD
A
N
TP
L
AQVM
P
E
L
V
E
QY
PD
T
Y
A
NM
G
I
H
DL
GD
T
MFAWL
KE
N
N
PG
A
RL
N
E
A
Y
SG
LP
V
A
E
V
TP
RE
A
Y
N
AI
V
D
N
N
VE
L
V
S
I
E
N
L
P
GRI
A
AN
SVI
PYPPG
I
P
M
L
LS
GE
N
F
G
D
KNS
P
QV
S
Y
L
R
S
L
Q
S
W
D
H
H
F
PGFE
HETE
G
T
EI-I
DG
I
Y
H
V
M
CV
K
fig|511145.6.peg.4227
Escherichia coli str. K-12 substr. MG1655 (22-755/756)
V
E
R
L
AD
AL
SQ
QN
VTV
I
K
S
T
S
F
DD
GFA
I
LS
S
N
E
A
I
DCLM
F
SYQ
M
E
H
P
D
EH
Q
N
V
R
QL
IGKLHERQQ
N
V
P
VFLL
G
DR
E
KA
L
AAM
DR
---
DL
L
E
-----
L
V
D
E
F
AWI
L
ED
T
A
DF
IA
G
R
AV
A
A
M
T
R
Y
RQQ
L
LPPL
FS
AL
M
KY
S
D
I
H
E
Y
SWAA
PGH
Q
GG
VG
F
T
K
T
P
A
G
R
FYH
D
YY
G
E
N
L
F
R
T
D
M
G
I
ER
T
S
LGSLLDHTG
AF
G
E
S
E
K
Y
A
ARVFGADRS
W
S
V
VV
GTS
G
SN
RTIMQA
C
MT
D
NDV
V
VV
DRNCHKS
I
E
QG
LM
L
T
GA
K
PVY
MV
P
S
RN
R
YGI
I
G
P
I
Y
PQ
E
M
Q
PE
T
L
Q
KK
I
S
E
S
P
LTKDK
A
G
Q
K
P
SYC
V
V
TN
C
TYDG
VC
YN
AK
E
AQ
D
L
L
EK
T
S
DRL
HFD
E
AW
YG
Y
A
R
F
N
PIY
A
DH
Y
A
M
R
GE
--
PGDH
N
G
PTV
F
A
T
H
STHKLL
N
ALSQAS
Y
IHV
REG
-
R
G
AI
N
FS
R
FN
Q
AYMMH
A
TTSP
L
Y
A
I
C
AS
N
DV
A
VS
MM
D
GN
S
G
LS
L
TQ
E
V
I
DE
A
V
D
FR
QA
M
A
---
RL
Y
K
E
FTADGS
WFF
K
P
W
NK
EV
V
T
D
PQTGKTYDFADAPTKLLTTV
Q
D
CW
V
M
H
PGE
S
WHGF
--
KDI
P
D
N
WS
M
LDPIKV
S
IL
A
PGM
G
EDG
E
LE
E
T
G
V
PAALV
TA
W
L
GR
HGIV
PTR
T
TDFQIM
FLFS
M
G
VTRG
K
W
GT
L
VN
T
L
C
S
FKR
H
YD
A
N
TP
L
AQVM
P
E
L
V
E
QY
PD
T
Y
A
NM
G
I
H
DL
GD
T
MFAWL
KE
N
N
PG
A
RL
N
E
A
Y
SG
LP
V
A
E
V
TP
RE
A
Y
N
AI
V
D
N
N
VE
L
V
S
I
E
N
L
P
GRI
A
AN
SVI
PYPPG
I
P
M
L
LS
GE
N
F
G
D
KNS
P
QV
S
Y
L
R
S
L
Q
S
W
D
H
H
F
PGFE
HETE
G
T
EI-I
DG
I
Y
H
V
M
CV
K
fig|413997.3.peg.4207
Escherichia coli B str. REL606 (22-755/756)
V
E
R
L
AD
AL
SQ
QN
VTV
I
K
S
T
S
F
DD
GFA
I
LS
S
N
E
A
I
DCLM
F
SYQ
M
E
H
P
D
EH
Q
N
V
R
QL
IGKLHERQQ
N
V
P
VFLL
G
DR
E
KA
L
AAM
DR
---
DL
L
E
-----
L
V
D
E
F
AWI
L
ED
T
A
DF
IA
G
R
AV
A
A
M
T
R
Y
RQQ
L
LPPL
FS
AL
M
KY
S
D
I
H
E
Y
SWAA
PGH
Q
GG
VG
F
T
K
T
P
A
G
R
FYH
D
YY
G
E
N
L
F
R
T
D
M
G
I
ER
T
S
LGSLLDHTG
AF
G
E
S
E
K
Y
A
ARVFGADRS
W
S
V
VV
GTS
G
SN
RTIMQA
C
MT
D
NDV
V
VV
DRNCHKS
I
E
QG
LM
L
T
GA
K
PVY
MV
P
S
RN
R
YGI
I
G
P
I
Y
PQ
E
M
Q
PE
T
L
Q
KK
I
S
E
S
P
LTKDK
A
G
Q
K
P
SYC
V
V
TN
C
TYDG
VC
YN
AK
E
AQ
D
L
L
EK
T
S
DRL
HFD
E
AW
YG
Y
A
R
F
N
PIY
A
DH
Y
A
M
R
GE
--
PGDH
N
G
PTV
F
A
T
H
STHKLL
N
ALSQAS
Y
IHV
REG
-
R
G
AI
N
FS
R
FN
Q
AYMMH
A
TTSP
L
Y
A
I
C
AS
N
DV
A
VS
MM
D
GN
S
G
LS
L
TQ
E
V
I
DE
A
V
D
FR
QA
M
A
---
RL
Y
K
E
FTADGS
WFF
K
P
W
NK
EV
V
T
D
PQTGKTYDFADAPTKLLTTV
Q
D
CW
V
M
H
PGE
S
WHGF
--
KDI
P
D
N
WS
M
LDPIKV
S
IL
A
PGM
G
EDG
E
LE
E
T
G
V
PAALV
TA
W
L
GR
HGIV
PTR
T
TDFQIM
FLFS
M
G
VTRG
K
W
GT
L
VN
T
L
C
S
FKR
H
YD
A
N
TP
L
AQVM
P
E
L
V
E
QY
PD
T
Y
A
NM
G
I
H
DL
GD
T
MFAWL
KE
N
N
PG
A
RL
N
A
A
Y
SG
LP
V
A
E
V
TP
RE
A
Y
N
AI
V
D
N
N
VE
L
V
S
I
E
N
L
P
GRI
A
AN
SVI
PYPPG
I
P
M
L
LS
GE
N
F
G
D
KNS
P
QV
S
Y
L
R
S
L
Q
S
W
D
H
H
F
PGFE
HETE
G
T
EI-I
DG
I
Y
H
V
M
CV
K
fig|511693.5.peg.4228
Escherichia coli BL21 (22-755/756)
V
E
R
L
AD
AL
SQ
QN
VTV
I
K
S
T
S
F
DD
GFA
I
LS
S
N
E
A
I
DCLM
F
SYQ
M
E
H
P
D
EH
Q
N
V
R
QL
IGKLHERQQ
N
V
P
VFLL
G
DR
E
KA
L
AAM
DR
---
DL
L
E
-----
L
V
D
E
F
AWI
L
ED
T
A
DF
IA
G
R
AV
A
A
M
T
R
Y
RQQ
L
LPPL
FS
AL
M
KY
S
D
I
H
E
Y
SWAA
PGH
Q
GG
VG
F
T
K
T
P
A
G
R
FYH
D
YY
G
E
N
L
F
R
T
D
M
G
I
ER
T
S
LGSLLDHTG
AF
G
E
S
E
K
Y
A
ARVFGADRS
W
S
V
VV
GTS
G
SN
RTIMQA
C
MT
D
NDV
V
VV
DRNCHKS
I
E
QG
LM
L
T
GA
K
PVY
MV
P
S
RN
R
YGI
I
G
P
I
Y
PQ
E
M
Q
PE
T
L
Q
KK
I
S
E
S
P
LTKDK
A
G
Q
K
P
SYC
V
V
TN
C
TYDG
VC
YN
AK
E
AQ
D
L
L
EK
T
S
DRL
HFD
E
AW
YG
Y
A
R
F
N
PIY
A
DH
Y
A
M
R
GE
--
PGDH
N
G
PTV
F
A
T
H
STHKLL
N
ALSQAS
Y
IHV
REG
-
R
G
AI
N
FS
R
FN
Q
AYMMH
A
TTSP
L
Y
A
I
C
AS
N
DV
A
VS
MM
D
GN
S
G
LS
L
TQ
E
V
I
DE
A
V
D
FR
QA
M
A
---
RL
Y
K
E
FTADGS
WFF
K
P
W
NK
EV
V
T
D
PQTGKTYDFADAPTKLLTTV
Q
D
CW
V
M
H
PGE
S
WHGF
--
KDI
P
D
N
WS
M
LDPIKV
S
IL
A
PGM
G
EDG
E
LE
E
T
G
V
PAALV
TA
W
L
GR
HGIV
PTR
T
TDFQIM
FLFS
M
G
VTRG
K
W
GT
L
VN
T
L
C
S
FKR
H
YD
A
N
TP
L
AQVM
P
E
L
V
E
QY
PD
T
Y
A
NM
G
I
H
DL
GD
T
MFAWL
KE
N
N
PG
A
RL
N
A
A
Y
SG
LP
V
A
E
V
TP
RE
A
Y
N
AI
V
D
N
N
VE
L
V
S
I
E
N
L
P
GRI
A
AN
SVI
PYPPG
I
P
M
L
LS
GE
N
F
G
D
KNS
P
QV
S
Y
L
R
S
L
Q
S
W
D
H
H
F
PGFE
HETE
G
T
EI-I
DG
I
Y
H
V
M
CV
K
fig|469008.4.peg.4062
Escherichia coli BL21(DE3) (22-755/756)
V
E
R
L
AD
AL
SQ
QN
VTV
I
K
S
T
S
F
DD
GFA
I
LS
S
N
E
A
I
DCLM
F
SYQ
M
E
H
P
D
EH
Q
N
V
R
QL
IGKLHERQQ
N
V
P
VFLL
G
DR
E
KA
L
AAM
DR
---
DL
L
E
-----
L
V
D
E
F
AWI
L
ED
T
A
DF
IA
G
R
AV
A
A
M
T
R
Y
RQQ
L
LPPL
FS
AL
M
KY
S
D
I
H
E
Y
SWAA
PGH
Q
GG
VG
F
T
K
T
P
A
G
R
FYH
D
YY
G
E
N
L
F
R
T
D
M
G
I
ER
T
S
LGSLLDHTG
AF
G
E
S
E
K
Y
A
ARVFGADRS
W
S
V
VV
GTS
G
SN
RTIMQA
C
MT
D
NDV
V
VV
DRNCHKS
I
E
QG
LM
L
T
GA
K
PVY
MV
P
S
RN
R
YGI
I
G
P
I
Y
PQ
E
M
Q
PE
T
L
Q
KK
I
S
E
S
P
LTKDK
A
G
Q
K
P
SYC
V
V
TN
C
TYDG
VC
YN
AK
E
AQ
D
L
L
EK
T
S
DRL
HFD
E
AW
YG
Y
A
R
F
N
PIY
A
DH
Y
A
M
R
GE
--
PGDH
N
G
PTV
F
A
T
H
STHKLL
N
ALSQAS
Y
IHV
REG
-
R
G
AI
N
FS
R
FN
Q
AYMMH
A
TTSP
L
Y
A
I
C
AS
N
DV
A
VS
MM
D
GN
S
G
LS
L
TQ
E
V
I
DE
A
V
D
FR
QA
M
A
---
RL
Y
K
E
FTADGS
WFF
K
P
W
NK
EV
V
T
D
PQTGKTYDFADAPTKLLTTV
Q
D
CW
V
M
H
PGE
S
WHGF
--
KDI
P
D
N
WS
M
LDPIKV
S
IL
A
PGM
G
EDG
E
LE
E
T
G
V
PAALV
TA
W
L
GR
HGIV
PTR
T
TDFQIM
FLFS
M
G
VTRG
K
W
GT
L
VN
T
L
C
S
FKR
H
YD
A
N
TP
L
AQVM
P
E
L
V
E
QY
PD
T
Y
A
NM
G
I
H
DL
GD
T
MFAWL
KE
N
N
PG
A
RL
N
A
A
Y
SG
LP
V
A
E
V
TP
RE
A
Y
N
AI
V
D
N
N
VE
L
V
S
I
E
N
L
P
GRI
A
AN
SVI
PYPPG
I
P
M
L
LS
GE
N
F
G
D
KNS
P
QV
S
Y
L
R
S
L
Q
S
W
D
H
H
F
PGFE
HETE
G
T
EI-I
DG
I
Y
H
V
M
CV
K
fig|316385.5.peg.4262
Escherichia coli str. K-12 substr. DH10B (22-755/756)
V
E
R
L
AD
AL
SQ
QN
VTV
I
K
S
T
S
F
DD
GFA
I
LS
S
N
E
A
I
DCLM
F
SYQ
M
E
H
P
D
EH
Q
N
V
R
QL
IGKLHERQQ
N
V
P
VFLL
G
DR
E
KA
L
AAM
DR
---
DL
L
E
-----
L
V
D
E
F
AWI
L
ED
T
A
DF
IA
G
R
AV
A
A
M
T
R
Y
RQQ
L
LPPL
FS
AL
M
KY
S
D
I
H
E
Y
SWAA
PGH
Q
GG
VG
F
T
K
T
P
A
G
R
FYH
D
YY
G
E
N
L
F
R
T
D
M
G
I
ER
T
S
LGSLLDHTG
AF
G
E
S
E
K
Y
A
ARVFGADRS
W
S
V
VV
GTS
G
SN
RTIMQA
C
MT
D
NDV
V
VV
DRNCHKS
I
E
QG
LM
L
T
GA
K
PVY
MV
P
S
RN
R
YGI
I
G
P
I
Y
PQ
E
M
Q
PE
T
L
Q
KK
I
S
E
S
P
LTKDK
A
G
Q
K
P
SYC
V
V
TN
C
TYDG
VC
YN
AK
E
AQ
D
L
L
EK
T
S
DRL
HFD
E
AW
YG
Y
A
R
F
N
PIY
A
DH
Y
A
M
R
GE
--
PGDH
N
G
PTV
F
A
T
H
STHKLL
N
ALSQAS
Y
IHV
REG
-
R
G
AI
N
FS
R
FN
Q
AYMMH
A
TTSP
L
Y
A
I
C
AS
N
DV
A
VS
MM
D
GN
S
G
LS
L
TQ
E
V
I
DE
A
V
D
FR
QA
M
A
---
RL
Y
K
E
FTADGS
WFF
K
P
W
NK
EV
V
T
D
PQTGKTYDFADAPTKLLTTV
Q
D
CW
V
M
H
PGE
S
WHGF
--
KDI
P
D
N
WS
M
LDPIK
I
S
IL
A
PGM
G
EDG
E
LE
E
T
G
V
PAALV
TA
W
L
GR
HGIV
PTR
T
TDFQIM
FLFS
M
G
VTRG
K
W
GT
L
VN
T
L
C
S
FKR
H
YD
A
N
TP
L
AQVM
P
E
L
V
E
QY
PD
T
Y
A
NM
G
I
H
DL
GD
T
MFAWL
KE
N
N
PG
A
RL
N
E
A
Y
SG
LP
V
A
E
V
TP
RE
A
Y
N
AI
V
D
N
N
VE
L
V
S
I
E
N
L
P
GRI
A
AN
SVI
PYPPG
I
P
M
L
LS
GE
N
F
G
D
KNS
P
QV
S
Y
L
R
S
L
Q
S
W
D
H
H
F
PGFE
HETE
G
T
EI-I
DG
I
Y
H
V
M
CV
K
fig|316385.7.peg.4351
Escherichia coli str. K-12 substr. DH10B (22-755/756)
V
E
R
L
AD
AL
SQ
QN
VTV
I
K
S
T
S
F
DD
GFA
I
LS
S
N
E
A
I
DCLM
F
SYQ
M
E
H
P
D
EH
Q
N
V
R
QL
IGKLHERQQ
N
V
P
VFLL
G
DR
E
KA
L
AAM
DR
---
DL
L
E
-----
L
V
D
E
F
AWI
L
ED
T
A
DF
IA
G
R
AV
A
A
M
T
R
Y
RQQ
L
LPPL
FS
AL
M
KY
S
D
I
H
E
Y
SWAA
PGH
Q
GG
VG
F
T
K
T
P
A
G
R
FYH
D
YY
G
E
N
L
F
R
T
D
M
G
I
ER
T
S
LGSLLDHTG
AF
G
E
S
E
K
Y
A
ARVFGADRS
W
S
V
VV
GTS
G
SN
RTIMQA
C
MT
D
NDV
V
VV
DRNCHKS
I
E
QG
LM
L
T
GA
K
PVY
MV
P
S
RN
R
YGI
I
G
P
I
Y
PQ
E
M
Q
PE
T
L
Q
KK
I
S
E
S
P
LTKDK
A
G
Q
K
P
SYC
V
V
TN
C
TYDG
VC
YN
AK
E
AQ
D
L
L
EK
T
S
DRL
HFD
E
AW
YG
Y
A
R
F
N
PIY
A
DH
Y
A
M
R
GE
--
PGDH
N
G
PTV
F
A
T
H
STHKLL
N
ALSQAS
Y
IHV
REG
-
R
G
AI
N
FS
R
FN
Q
AYMMH
A
TTSP
L
Y
A
I
C
AS
N
DV
A
VS
MM
D
GN
S
G
LS
L
TQ
E
V
I
DE
A
V
D
FR
QA
M
A
---
RL
Y
K
E
FTADGS
WFF
K
P
W
NK
EV
V
T
D
PQTGKTYDFADAPTKLLTTV
Q
D
CW
V
M
H
PGE
S
WHGF
--
KDI
P
D
N
WS
M
LDPIK
I
S
IL
A
PGM
G
EDG
E
LE
E
T
G
V
PAALV
TA
W
L
GR
HGIV
PTR
T
TDFQIM
FLFS
M
G
VTRG
K
W
GT
L
VN
T
L
C
S
FKR
H
YD
A
N
TP
L
AQVM
P
E
L
V
E
QY
PD
T
Y
A
NM
G
I
H
DL
GD
T
MFAWL
KE
N
N
PG
A
RL
N
E
A
Y
SG
LP
V
A
E
V
TP
RE
A
Y
N
AI
V
D
N
N
VE
L
V
S
I
E
N
L
P
GRI
A
AN
SVI
PYPPG
I
P
M
L
LS
GE
N
F
G
D
KNS
P
QV
S
Y
L
R
S
L
Q
S
W
D
H
H
F
PGFE
HETE
G
T
EI-I
DG
I
Y
H
V
M
CV
K
fig|670897.3.peg.1434
Escherichia coli 2362-75 (22-755/756)
V
E
R
L
AD
AL
SQ
QN
VTV
I
K
S
T
S
F
DD
GFA
I
LS
S
N
E
A
I
DCLM
F
SYQ
M
E
H
P
D
EH
Q
N
V
R
QL
IGKLHERQQ
N
V
P
VFLL
G
DR
E
KA
L
AAM
DR
---
DL
L
E
-----
L
V
D
E
F
AWI
L
ED
T
A
DF
IA
G
R
AV
A
A
M
T
R
Y
RQQ
L
LPPL
FS
AL
M
KY
S
D
I
H
E
Y
SWAA
PGH
Q
GG
VG
F
T
K
T
P
A
G
R
FYH
D
YY
G
E
N
L
F
R
T
D
M
G
I
ER
T
S
LGSLLDHTG
AF
G
E
S
E
K
Y
A
ARVFGADRS
W
S
V
VV
GTS
G
SN
RTIMQA
C
MT
D
NDV
V
VV
DRNCHKS
I
E
QG
LM
L
T
GA
K
PVY
MV
P
S
RN
R
YGI
I
G
P
I
Y
PQ
E
M
Q
PE
T
L
Q
KK
I
N
E
S
P
LTKDK
A
G
Q
K
P
SYC
V
V
TN
C
TYDG
VC
YN
AK
E
AQ
D
L
L
EK
T
S
DRL
HFD
E
AW
YG
Y
A
R
F
N
PIY
A
DH
Y
A
M
R
GE
--
PGDH
N
G
PTV
F
A
T
H
STHKLL
N
ALSQAS
Y
IHV
REG
-
R
G
AI
N
FS
R
FN
Q
AYMMH
A
TTSP
L
Y
A
I
C
AS
N
DV
A
VS
MM
D
GN
S
G
LS
L
TQ
E
V
I
DE
A
V
D
FR
QA
M
A
---
RL
Y
K
E
FTADGS
WFF
K
P
W
NK
EV
V
T
D
PQTGKTYDFADAPTKLLTTV
Q
D
CW
V
M
H
PGE
S
WHGF
--
KDI
P
D
N
WS
M
LDPIKV
S
IL
A
PGM
G
EDG
E
LE
E
T
G
V
PAALV
TA
W
L
GR
HGIV
PTR
T
TDFQIM
FLFS
M
G
VTRG
K
W
GT
L
VN
T
L
C
S
FKR
H
YD
A
N
TP
L
AQVM
P
E
L
V
E
QY
PD
T
Y
A
NM
G
I
H
DL
GD
T
MFAWL
KE
N
N
PG
A
RL
N
E
A
Y
SG
LP
V
A
E
I
TP
RE
A
Y
N
AI
V
D
N
N
VE
L
V
S
I
E
N
L
P
GRI
A
AN
SVI
PYPPG
I
P
M
L
LS
GE
N
F
G
D
KNS
P
QV
S
Y
L
R
S
L
Q
S
W
D
H
H
F
PGFE
HETE
G
T
EI-I
DG
I
Y
H
V
M
CV
K
fig|216593.1.peg.3887
Escherichia coli E2348/69 (22-755/756)
V
E
R
L
AD
AL
SQ
QN
VTV
I
K
S
T
S
F
DD
GFA
I
LS
S
N
E
A
I
DCLM
F
SYQ
M
E
H
P
D
EH
Q
N
V
R
QL
IGKLHERQQ
N
V
P
VFLL
G
DR
E
KA
L
AAM
DR
---
DL
L
E
-----
L
V
D
E
F
AWI
L
ED
T
A
DF
IA
G
R
AV
A
A
M
T
R
Y
RQQ
L
LPPL
FS
AL
M
KY
S
D
I
H
E
Y
SWAA
PGH
Q
GG
VG
F
T
K
T
P
A
G
R
FYH
D
YY
G
E
N
L
F
R
T
D
M
G
I
ER
T
S
LGSLLDHTG
AF
G
E
S
E
K
Y
A
ARVFGADRS
W
S
V
VV
GTS
G
SN
RTIMQA
C
MT
D
NDV
V
VV
DRNCHKS
I
E
QG
LM
L
T
GA
K
PVY
MV
P
S
RN
R
YGI
I
G
P
I
Y
PQ
E
M
Q
PE
T
L
Q
KK
I
N
E
S
P
LTKDK
A
G
Q
K
P
SYC
V
V
TN
C
TYDG
VC
YN
AK
E
AQ
D
L
L
EK
T
S
DRL
HFD
E
AW
YG
Y
A
R
F
N
PIY
A
DH
Y
A
M
R
GE
--
PGDH
N
G
PTV
F
A
T
H
STHKLL
N
ALSQAS
Y
IHV
REG
-
R
G
AI
N
FS
R
FN
Q
AYMMH
A
TTSP
L
Y
A
I
C
AS
N
DV
A
VS
MM
D
GN
S
G
LS
L
TQ
E
V
I
DE
A
V
D
FR
QA
M
A
---
RL
Y
K
E
FTADGS
WFF
K
P
W
NK
EV
V
T
D
PQTGKTYDFADAPTKLLTTV
Q
D
CW
V
M
H
PGE
S
WHGF
--
KDI
P
D
N
WS
M
LDPIKV
S
IL
A
PGM
G
EDG
E
LE
E
T
G
V
PAALV
TA
W
L
GR
HGIV
PTR
T
TDFQIM
FLFS
M
G
VTRG
K
W
GT
L
VN
T
L
C
S
FKR
H
YD
A
N
TP
L
AQVM
P
E
L
V
E
QY
PD
T
Y
A
NM
G
I
H
DL
GD
T
MFAWL
KE
N
N
PG
A
RL
N
E
A
Y
SG
LP
V
A
E
I
TP
RE
A
Y
N
AI
V
D
N
N
VE
L
V
S
I
E
N
L
P
GRI
A
AN
SVI
PYPPG
I
P
M
L
LS
GE
N
F
G
D
KNS
P
QV
S
Y
L
R
S
L
Q
S
W
D
H
H
F
PGFE
HETE
G
T
EI-I
DG
I
Y
H
V
M
CV
K
fig|585057.4.peg.4681
Escherichia coli IAI39 (22-755/756)
V
E
R
L
AD
AL
SQ
QN
VTV
I
K
S
T
S
F
DD
GFA
I
LS
S
N
E
A
I
DCLM
F
SYQ
M
E
H
P
D
EH
Q
N
V
R
QL
IGKLHERQQ
N
V
P
VFLL
G
DR
E
KA
L
AAM
DR
---
DL
L
E
-----
L
V
D
E
F
AWI
L
ED
T
A
DF
IA
G
R
AV
A
A
M
T
R
Y
RQQ
L
LPPL
FS
AL
M
KY
S
D
I
H
E
Y
SWAA
PGH
Q
GG
VG
F
T
K
T
P
A
G
R
FYH
D
YY
G
E
N
L
F
R
T
D
M
G
I
ER
T
S
LGSLLDHTG
AF
G
E
S
E
K
Y
A
ARVFGADRS
W
S
V
VV
GTS
G
SN
RTIMQA
C
MT
D
NDV
V
VV
DRNCHKS
I
E
QG
LM
L
T
GA
K
PVY
MV
P
S
RN
R
YGI
I
G
P
I
Y
PQ
E
M
Q
PE
T
L
Q
KK
I
N
E
S
P
LTKDK
A
G
Q
K
P
SYC
V
V
TN
C
TYDG
VC
YN
AK
E
AQ
D
L
L
EK
T
S
DRL
HFD
E
AW
YG
Y
A
R
F
N
PIY
A
DH
Y
A
M
R
GE
--
PGDH
N
G
PTV
F
A
T
H
STHKLL
N
ALSQAS
Y
IHV
REG
-
R
G
AI
N
FS
R
FN
Q
AYMMH
A
TTSP
L
Y
A
I
C
AS
N
DV
A
VS
MM
D
GN
S
G
LS
L
TQ
E
V
I
DE
A
V
D
FR
QA
M
A
---
RL
Y
K
E
FTADGS
WFF
K
P
W
NK
EV
V
T
D
PQTGKTYDFADAPTKLLTTV
Q
D
CW
V
M
H
PGE
S
WHGF
--
KDI
P
D
N
WS
M
LDPIKV
S
IL
A
PGM
G
EDG
E
LE
E
T
G
V
PAALV
TA
W
L
GR
HGIV
PTR
T
TDFQIM
FLFS
M
G
VTRG
K
W
GT
L
VN
T
L
C
S
FKR
H
YD
A
N
TP
L
AQVM
P
E
L
V
E
QY
PD
T
Y
A
NM
G
I
H
DL
GD
T
MFAWL
KE
N
N
PG
A
RL
N
E
A
Y
SG
LP
V
A
E
I
TP
RE
A
Y
N
AI
V
D
N
N
VE
L
V
S
I
E
N
L
P
GRI
A
AN
SVI
PYPPG
I
P
M
L
LS
GE
N
F
G
D
KNS
P
QV
S
Y
L
R
S
L
Q
S
W
D
H
H
F
PGFE
HETE
G
T
EI-I
DG
I
Y
H
V
M
CV
K
fig|585057.6.peg.4690
Escherichia coli IAI39 (22-755/756)
V
E
R
L
AD
AL
SQ
QN
VTV
I
K
S
T
S
F
DD
GFA
I
LS
S
N
E
A
I
DCLM
F
SYQ
M
E
H
P
D
EH
Q
N
V
R
QL
IGKLHERQQ
N
V
P
VFLL
G
DR
E
KA
L
AAM
DR
---
DL
L
E
-----
L
V
D
E
F
AWI
L
ED
T
A
DF
IA
G
R
AV
A
A
M
T
R
Y
RQQ
L
LPPL
FS
AL
M
KY
S
D
I
H
E
Y
SWAA
PGH
Q
GG
VG
F
T
K
T
P
A
G
R
FYH
D
YY
G
E
N
L
F
R
T
D
M
G
I
ER
T
S
LGSLLDHTG
AF
G
E
S
E
K
Y
A
ARVFGADRS
W
S
V
VV
GTS
G
SN
RTIMQA
C
MT
D
NDV
V
VV
DRNCHKS
I
E
QG
LM
L
T
GA
K
PVY
MV
P
S
RN
R
YGI
I
G
P
I
Y
PQ
E
M
Q
PE
T
L
Q
KK
I
N
E
S
P
LTKDK
A
G
Q
K
P
SYC
V
V
TN
C
TYDG
VC
YN
AK
E
AQ
D
L
L
EK
T
S
DRL
HFD
E
AW
YG
Y
A
R
F
N
PIY
A
DH
Y
A
M
R
GE
--
PGDH
N
G
PTV
F
A
T
H
STHKLL
N
ALSQAS
Y
IHV
REG
-
R
G
AI
N
FS
R
FN
Q
AYMMH
A
TTSP
L
Y
A
I
C
AS
N
DV
A
VS
MM
D
GN
S
G
LS
L
TQ
E
V
I
DE
A
V
D
FR
QA
M
A
---
RL
Y
K
E
FTADGS
WFF
K
P
W
NK
EV
V
T
D
PQTGKTYDFADAPTKLLTTV
Q
D
CW
V
M
H
PGE
S
WHGF
--
KDI
P
D
N
WS
M
LDPIKV
S
IL
A
PGM
G
EDG
E
LE
E
T
G
V
PAALV
TA
W
L
GR
HGIV
PTR
T
TDFQIM
FLFS
M
G
VTRG
K
W
GT
L
VN
T
L
C
S
FKR
H
YD
A
N
TP
L
AQVM
P
E
L
V
E
QY
PD
T
Y
A
NM
G
I
H
DL
GD
T
MFAWL
KE
N
N
PG
A
RL
N
E
A
Y
SG
LP
V
A
E
I
TP
RE
A
Y
N
AI
V
D
N
N
VE
L
V
S
I
E
N
L
P
GRI
A
AN
SVI
PYPPG
I
P
M
L
LS
GE
N
F
G
D
KNS
P
QV
S
Y
L
R
S
L
Q
S
W
D
H
H
F
PGFE
HETE
G
T
EI-I
DG
I
Y
H
V
M
CV
K
fig|753642.3.peg.4017
Escherichia coli NC101 (22-755/756)
V
E
R
L
AD
AL
SQ
QN
VTV
I
K
S
T
S
F
DD
GFA
I
LS
S
N
E
A
I
DCLM
F
SYQ
M
E
H
P
D
EH
Q
N
V
R
QL
IGKLHERQQ
N
V
P
VFLL
G
DR
E
KA
L
AAM
DR
---
DL
L
E
-----
L
V
D
E
F
AWI
L
ED
T
A
DF
IA
G
R
AV
A
A
M
T
R
Y
RQQ
L
LPPL
FS
AL
M
KY
S
D
I
H
E
Y
SWAA
PGH
Q
GG
VG
F
T
K
T
P
A
G
R
FYH
D
YY
G
E
N
L
F
R
T
D
M
G
I
ER
T
S
LGSLLDHTG
AF
G
E
S
E
K
Y
A
ARVFGADRS
W
S
V
VV
GTS
G
SN
RTIMQA
C
MT
D
NDV
V
VV
DRNCHKS
I
E
QG
LM
L
T
GA
K
PVY
MV
P
S
RN
R
YGI
I
G
P
I
Y
PQ
E
M
Q
PE
T
L
Q
KK
I
N
E
S
P
LTKDK
A
G
Q
K
P
SYC
V
V
TN
C
TYDG
VC
YN
AK
E
AQ
D
L
L
EK
T
S
DRL
HFD
E
AW
YG
Y
A
R
F
N
PIY
A
DH
Y
A
M
R
GE
--
PGDH
N
G
PTV
F
A
T
H
STHKLL
N
ALSQAS
Y
IHV
REG
-
R
G
AI
N
FS
R
FN
Q
AYMMH
A
TTSP
L
Y
A
I
C
AS
N
DV
A
VS
MM
D
GN
S
G
LS
L
TQ
E
V
I
DE
A
V
D
FR
QA
M
A
---
RL
Y
K
E
FTADGS
WFF
K
P
W
NK
EV
V
T
D
PQTGKTYDFADAPTKLLTTV
Q
D
CW
V
M
H
PGE
S
WHGF
--
KDI
P
D
N
WS
M
LDPIKV
S
IL
A
PGM
G
EDG
E
LE
E
T
G
V
PAALV
TA
W
L
GR
HGIV
PTR
T
TDFQIM
FLFS
M
G
VTRG
K
W
GT
L
VN
T
L
C
S
FKR
H
YD
A
N
TP
L
AQVM
P
E
L
V
E
QY
PD
T
Y
A
NM
G
I
H
DL
GD
T
MFAWL
KE
N
N
PG
A
RL
N
E
A
Y
SG
LP
V
A
E
I
TP
RE
A
Y
N
AI
V
D
N
N
VE
L
V
S
I
E
N
L
P
GRI
A
AN
SVI
PYPPG
I
P
M
L
LS
GE
N
F
G
D
KNS
P
QV
S
Y
L
R
S
L
Q
S
W
D
H
H
F
PGFE
HETE
G
T
EI-I
DG
I
Y
H
V
M
CV
K
fig|574521.7.peg.4546
Escherichia coli O127:H6 str. E2348/69 (22-755/756)
V
E
R
L
AD
AL
SQ
QN
VTV
I
K
S
T
S
F
DD
GFA
I
LS
S
N
E
A
I
DCLM
F
SYQ
M
E
H
P
D
EH
Q
N
V
R
QL
IGKLHERQQ
N
V
P
VFLL
G
DR
E
KA
L
AAM
DR
---
DL
L
E
-----
L
V
D
E
F
AWI
L
ED
T
A
DF
IA
G
R
AV
A
A
M
T
R
Y
RQQ
L
LPPL
FS
AL
M
KY
S
D
I
H
E
Y
SWAA
PGH
Q
GG
VG
F
T
K
T
P
A
G
R
FYH
D
YY
G
E
N
L
F
R
T
D
M
G
I
ER
T
S
LGSLLDHTG
AF
G
E
S
E
K
Y
A
ARVFGADRS
W
S
V
VV
GTS
G
SN
RTIMQA
C
MT
D
NDV
V
VV
DRNCHKS
I
E
QG
LM
L
T
GA
K
PVY
MV
P
S
RN
R
YGI
I
G
P
I
Y
PQ
E
M
Q
PE
T
L
Q
KK
I
N
E
S
P
LTKDK
A
G
Q
K
P
SYC
V
V
TN
C
TYDG
VC
YN
AK
E
AQ
D
L
L
EK
T
S
DRL
HFD
E
AW
YG
Y
A
R
F
N
PIY
A
DH
Y
A
M
R
GE
--
PGDH
N
G
PTV
F
A
T
H
STHKLL
N
ALSQAS
Y
IHV
REG
-
R
G
AI
N
FS
R
FN
Q
AYMMH
A
TTSP
L
Y
A
I
C
AS
N
DV
A
VS
MM
D
GN
S
G
LS
L
TQ
E
V
I
DE
A
V
D
FR
QA
M
A
---
RL
Y
K
E
FTADGS
WFF
K
P
W
NK
EV
V
T
D
PQTGKTYDFADAPTKLLTTV
Q
D
CW
V
M
H
PGE
S
WHGF
--
KDI
P
D
N
WS
M
LDPIKV
S
IL
A
PGM
G
EDG
E
LE
E
T
G
V
PAALV
TA
W
L
GR
HGIV
PTR
T
TDFQIM
FLFS
M
G
VTRG
K
W
GT
L
VN
T
L
C
S
FKR
H
YD
A
N
TP
L
AQVM
P
E
L
V
E
QY
PD
T
Y
A
NM
G
I
H
DL
GD
T
MFAWL
KE
N
N
PG
A
RL
N
E
A
Y
SG
LP
V
A
E
I
TP
RE
A
Y
N
AI
V
D
N
N
VE
L
V
S
I
E
N
L
P
GRI
A
AN
SVI
PYPPG
I
P
M
L
LS
GE
N
F
G
D
KNS
P
QV
S
Y
L
R
S
L
Q
S
W
D
H
H
F
PGFE
HETE
G
T
EI-I
DG
I
Y
H
V
M
CV
K
fig|439855.10.peg.4695
Escherichia coli SMS-3-5 (22-755/756)
V
E
R
L
AD
AL
SQ
QN
VTV
I
K
S
T
S
F
DD
GFA
I
LS
S
N
E
A
I
DCLM
F
SYQ
M
E
H
P
D
EH
Q
N
V
R
QL
IGKLHERQQ
N
V
P
VFLL
G
DR
E
KA
L
AAM
DR
---
DL
L
E
-----
L
V
D
E
F
AWI
L
ED
T
A
DF
IA
G
R
AV
A
A
M
T
R
Y
RQQ
L
LPPL
FS
AL
M
KY
S
D
I
H
E
Y
SWAA
PGH
Q
GG
VG
F
T
K
T
P
A
G
R
FYH
D
YY
G
E
N
L
F
R
T
D
M
G
I
ER
T
S
LGSLLDHTG
AF
G
E
S
E
K
Y
A
ARVFGADRS
W
S
V
VV
GTS
G
SN
RTIMQA
C
MT
D
NDV
V
VV
DRNCHKS
I
E
QG
LM
L
T
GA
K
PVY
MV
P
S
RN
R
YGI
I
G
P
I
Y
PQ
E
M
Q
PE
T
L
Q
KK
I
N
E
S
P
LTKDK
A
G
Q
K
P
SYC
V
V
TN
C
TYDG
VC
YN
AK
E
AQ
D
L
L
EK
T
S
DRL
HFD
E
AW
YG
Y
A
R
F
N
PIY
A
DH
Y
A
M
R
GE
--
PGDH
N
G
PTV
F
A
T
H
STHKLL
N
ALSQAS
Y
IHV
REG
-
R
G
AI
N
FS
R
FN
Q
AYMMH
A
TTSP
L
Y
A
I
C
AS
N
DV
A
VS
MM
D
GN
S
G
LS
L
TQ
E
V
I
DE
A
V
D
FR
QA
M
A
---
RL
Y
K
E
FTADGS
WFF
K
P
W
NK
EV
V
T
D
PQTGKTYDFADAPTKLLTTV
Q
D
CW
V
M
H
PGE
S
WHGF
--
KDI
P
D
N
WS
M
LDPIKV
S
IL
A
PGM
G
EDG
E
LE
E
T
G
V
PAALV
TA
W
L
GR
HGIV
PTR
T
TDFQIM
FLFS
M
G
VTRG
K
W
GT
L
VN
T
L
C
S
FKR
H
YD
A
N
TP
L
AQVM
P
E
L
V
E
QY
PD
T
Y
A
NM
G
I
H
DL
GD
T
MFAWL
KE
N
N
PG
A
RL
N
E
A
Y
SG
LP
V
A
E
I
TP
RE
A
Y
N
AI
V
D
N
N
VE
L
V
S
I
E
N
L
P
GRI
A
AN
SVI
PYPPG
I
P
M
L
LS
GE
N
F
G
D
KNS
P
QV
S
Y
L
R
S
L
Q
S
W
D
H
H
F
PGFE
HETE
G
T
EI-I
DG
I
Y
H
V
M
CV
K
fig|749548.3.peg.11
Escherichia coli MS 196-1 (22-755/756)
V
E
R
L
AD
AL
SQ
QN
VTV
I
K
S
T
S
F
DD
GFA
I
LS
S
N
E
A
I
DCLM
F
SYQ
M
E
H
P
D
EH
Q
N
V
R
QL
IGKLHERQQ
N
V
P
VFLL
G
DR
E
KA
L
AAM
DR
---
DL
L
E
-----
L
V
D
E
F
AWI
L
ED
T
A
DF
IA
G
R
AV
A
A
M
T
R
Y
RQQ
L
LPPL
FS
AL
M
KY
S
D
I
H
E
Y
SWAA
PGH
Q
GG
VG
F
T
K
T
P
A
G
R
FYH
D
YY
G
E
N
L
F
R
T
D
M
G
I
ER
T
S
LGSLLDHTG
AF
G
E
S
E
K
Y
A
ARVFGADRS
W
S
V
VV
GTS
G
SN
RTIMQA
C
MT
D
NDV
V
VV
DRNCHKS
I
E
QG
LM
L
T
GA
K
PVY
MV
P
S
RN
R
YGI
I
G
P
I
Y
PQ
E
M
Q
PE
T
L
Q
KK
I
S
E
S
P
LTKDK
A
G
Q
K
P
SYC
V
V
TN
C
TYDG
VC
YN
AK
E
AQ
D
L
L
EK
T
S
DRL
HFD
E
AW
YG
Y
A
R
F
N
PIY
A
DH
Y
A
M
R
GE
--
PGDH
N
G
P
P
V
F
A
T
H
STHKLL
N
ALSQAS
Y
IHV
REG
-
R
G
AI
N
FS
R
FN
Q
AYMMH
A
TTSP
L
Y
A
I
C
AS
N
DV
A
VS
MM
D
GN
S
G
LS
L
TQ
E
V
I
DE
A
V
D
FR
QA
M
A
---
RL
Y
K
E
FTADGS
WFF
K
P
W
NK
EV
V
T
D
PQTGKTYDFADAPTKLLTTV
Q
D
CW
V
M
H
PGE
S
WHGF
--
KDI
P
D
N
WS
M
LDPIKV
S
IL
A
PGM
G
EDG
E
LE
E
T
G
V
PAALV
TA
W
L
GR
HGIV
PTR
T
TDFQIM
FLFS
M
G
VTRG
K
W
GT
L
VN
T
L
C
S
FKR
H
YD
A
N
TP
L
AQVM
P
E
L
V
E
QY
PD
T
Y
A
NM
G
I
H
DL
GD
T
MFAWL
KE
N
N
PG
A
RL
N
E
A
Y
SG
LP
V
A
E
V
TP
RE
A
Y
N
AI
V
D
N
N
VE
L
V
S
I
E
N
L
P
GRI
A
AN
SVI
PYPPG
I
P
M
L
LS
GE
N
F
G
D
KNS
P
QV
S
Y
L
R
S
L
Q
S
W
D
H
H
F
PGFE
HETE
G
T
EI-I
DG
I
Y
H
V
M
CV
K
fig|562.376.peg.1790
Escherichia coli WV_060327 (22-755/756)
V
E
R
L
AD
AL
SQ
QN
VTV
I
K
S
T
S
F
DD
GFA
I
LS
S
N
E
A
I
DCLM
F
SYQ
M
E
H
P
D
EH
Q
N
V
R
QL
IGKLHERQQ
N
V
P
VFLL
G
DR
E
KA
L
AAM
DR
---
DL
L
E
-----
L
V
D
E
F
AWI
L
ED
T
A
DF
IA
G
R
AV
A
A
M
T
R
Y
RQQ
L
LPPL
FS
AL
M
KY
S
D
I
H
E
Y
SWAA
PGH
Q
GG
VG
F
T
K
T
P
A
G
R
FYH
D
YY
G
E
N
L
F
R
T
D
M
G
I
ER
T
S
LGSLLDHTG
AF
G
E
S
E
R
Y
A
ARVFGADRS
W
S
V
VV
GTS
G
SN
RTIMQA
C
MT
D
NDV
V
VV
DRNCHKS
I
E
QG
LM
L
T
GA
K
PVY
MV
P
S
RN
R
YGI
I
G
P
I
Y
PQ
E
M
Q
PE
T
L
Q
KK
I
N
E
S
P
LTKDK
A
G
Q
K
P
SYC
V
V
TN
C
TYDG
VC
YN
AK
E
AQ
D
L
L
EK
T
S
DRL
HFD
E
AW
YG
Y
A
R
F
N
PIY
A
DH
Y
A
M
R
GE
--
PGDH
N
G
PTV
F
S
T
H
STHKLL
N
ALSQAS
Y
IHV
REG
-
R
G
AI
N
FS
R
FN
Q
AYMMH
A
TTSP
L
Y
A
I
C
AS
N
DV
A
VS
MM
D
GN
S
G
LS
L
TQ
E
V
I
DE
A
V
D
FR
QA
M
A
---
RL
Y
K
E
FTADGS
WFF
K
P
W
NK
EV
V
T
D
PQTGKTY
H
FADAPTKLLTTV
Q
D
CW
V
M
H
PGE
S
WHGF
--
KDI
P
D
N
WS
M
LDPIKV
S
IL
A
PGM
G
EDG
E
LE
E
T
G
V
PAALV
TA
W
L
GR
HGIV
PTR
T
TDFQIM
FLFS
M
G
VTRG
K
W
GT
L
VN
T
L
C
S
FKR
H
YD
A
N
TP
L
AQVM
P
E
L
V
E
QY
PD
T
Y
A
NM
G
I
H
DL
GD
T
MFAWL
KE
N
N
PG
A
RL
N
E
A
Y
SG
LP
V
A
E
I
TP
RE
A
Y
N
AI
V
D
N
N
VE
L
V
S
I
E
N
L
P
GRI
A
AN
SVI
PYPPG
I
P
M
L
LS
GE
N
F
G
D
KNS
P
QV
S
Y
L
R
S
L
Q
S
W
D
H
H
F
PGFE
HETE
G
T
EI-I
DG
I
Y
H
V
M
CV
K
fig|685038.3.peg.4219
Escherichia coli O83:H1 str. NRG 857C (22-755/756)
V
E
R
L
AD
AL
SQ
QN
VTV
I
K
S
T
S
F
DD
GFA
I
LS
S
N
E
A
I
DCLM
F
SYQ
M
E
H
P
D
EH
Q
N
V
R
QL
IGKLHERQQ
N
V
P
VFLL
G
DR
E
KA
L
AAM
DR
---
DL
L
E
-----
L
V
D
E
F
AWI
L
ED
T
A
DF
IA
G
R
AV
A
A
M
T
R
Y
RQQ
L
LPPL
FS
AL
M
KY
S
D
I
H
E
Y
SWAA
PGH
Q
GG
VG
F
T
K
T
P
A
G
R
FYH
D
YY
G
E
N
L
F
R
T
D
M
G
I
ER
T
S
LGSLLDHTG
AF
G
E
S
E
R
Y
A
ARVFGADRS
W
S
V
VV
GTS
G
SN
RTIMQA
C
MT
D
NDV
V
VV
DRNCHKS
I
E
QG
LM
L
T
GA
K
PVY
MV
P
S
RN
R
YGI
I
G
P
I
Y
PQ
E
M
Q
PE
T
L
Q
KK
I
N
E
S
P
LTKDK
A
G
Q
K
P
SYC
V
V
TN
C
TYDG
VC
YN
AK
E
AQ
D
L
L
EK
T
S
DRL
HFD
E
AW
YG
Y
A
R
F
N
PIY
A
DH
Y
A
M
R
GE
--
PGDH
N
G
PTV
F
A
T
H
STHKLL
N
ALSQAS
Y
IHV
REG
-
R
G
AI
N
FS
R
FN
Q
AYMMH
A
TTSP
L
Y
A
I
C
AS
N
DV
A
VS
MM
D
GN
S
G
LS
L
TQ
E
V
I
DE
A
V
D
FR
QA
M
A
---
RL
Y
K
E
FTADGS
WFF
K
P
W
NK
EV
V
T
D
PQTGKTYDFADAPTKLLTTV
Q
D
CW
V
M
H
PGE
S
WHGF
--
KDI
P
D
N
WS
M
LDPIKV
S
IL
A
PGM
G
EDG
E
LE
E
T
G
V
PAALV
TA
W
L
GR
HGIV
PTR
T
TDFQIM
FLFS
M
G
VTRG
K
W
GT
L
VN
T
L
C
S
FKR
H
YD
A
N
TP
L
AQVM
P
E
L
V
E
QY
PD
T
Y
A
NM
G
I
H
DL
GD
T
MFAWL
KE
N
N
PG
A
RL
N
E
A
Y
SG
LP
V
A
E
I
TP
RE
A
Y
N
AI
V
D
N
N
VE
L
V
S
I
E
N
L
P
GRI
A
AN
SVI
PYPPG
I
P
M
L
LS
GE
N
F
G
D
KNS
P
QV
S
Y
L
R
S
L
Q
S
W
D
H
H
F
PGFE
HETE
G
T
EI-I
DG
I
Y
H
V
M
CV
K
fig|525281.3.peg.1751
Escherichia coli 83972 (22-755/756)
V
E
R
L
AD
AL
SQ
QN
VTV
I
K
S
T
S
F
DD
GFA
I
LS
S
N
E
A
I
DCLM
F
SYQ
M
E
H
P
D
EH
Q
N
V
R
QL
IGKLHERQQ
N
V
P
VFLL
G
DR
E
KA
L
AAM
DR
---
DL
L
E
-----
L
V
D
E
F
AWI
L
ED
T
A
DF
IA
G
R
AV
A
A
M
T
R
Y
RQQ
L
LPPL
FS
AL
M
KY
S
D
I
H
E
Y
SWAA
PGH
Q
GG
VG
F
T
K
T
P
A
G
R
FYH
D
YY
G
E
N
L
F
R
T
D
M
G
I
ER
T
S
LGSLLDHTG
AF
G
E
S
E
K
Y
A
ARVFGADRS
W
S
V
VV
GTS
G
SN
RTIMQA
C
MT
D
NDV
V
VV
DRNCHKS
I
E
QG
LM
L
T
GA
K
PVY
MV
P
S
RN
R
YGI
I
G
P
I
Y
PQ
E
M
Q
PE
T
L
Q
KK
I
S
E
S
P
LTKDK
V
G
Q
K
P
SYC
V
V
TN
C
TYDG
VC
YN
AK
E
AQ
D
L
L
EK
T
S
DRL
HFD
E
AW
YG
Y
A
R
F
N
PIY
A
DH
Y
A
M
R
GE
--
PGDH
N
G
PTV
F
A
T
H
STHKLL
N
ALSQAS
Y
IHV
REG
-
R
G
AI
N
FS
R
FN
Q
AYMMH
A
TTSP
L
Y
A
I
C
AS
N
DV
A
VS
MM
D
GN
S
G
LS
L
TQ
E
V
I
DE
A
V
D
FR
QA
M
A
---
RL
Y
K
E
FTADGS
WFF
K
P
W
NK
EV
V
T
D
PQTGKTYDFADAPTKLLTTV
Q
D
CW
V
M
H
PGE
S
WHGF
--
KDI
P
D
N
WS
M
LDPIKV
S
IL
A
PGM
G
EDG
E
LE
E
I
G
V
PAALV
TA
W
L
GR
HGIV
PTR
T
TDFQIM
FLFS
M
G
VTRG
K
W
GT
L
VN
T
L
C
S
FKR
H
YD
A
N
TP
L
AQVM
P
E
L
V
E
QY
PD
T
Y
A
NM
G
I
H
DL
GD
T
MFAWL
KE
N
N
PG
A
RL
N
E
A
Y
SG
LP
V
A
E
I
TP
RE
A
Y
N
AI
V
D
N
N
VE
L
V
S
I
E
N
L
P
GRI
A
AN
SVI
PYPPG
I
P
M
L
LS
GE
N
F
G
D
KNS
P
QV
S
Y
L
R
S
L
Q
S
W
D
H
H
F
PGFE
HETE
G
T
EI-I
DG
I
Y
H
V
M
CV
K
fig|655817.3.peg.4866
Escherichia coli ABU 83972 (22-755/756)
V
E
R
L
AD
AL
SQ
QN
VTV
I
K
S
T
S
F
DD
GFA
I
LS
S
N
E
A
I
DCLM
F
SYQ
M
E
H
P
D
EH
Q
N
V
R
QL
IGKLHERQQ
N
V
P
VFLL
G
DR
E
KA
L
AAM
DR
---
DL
L
E
-----
L
V
D
E
F
AWI
L
ED
T
A
DF
IA
G
R
AV
A
A
M
T
R
Y
RQQ
L
LPPL
FS
AL
M
KY
S
D
I
H
E
Y
SWAA
PGH
Q
GG
VG
F
T
K
T
P
A
G
R
FYH
D
YY
G
E
N
L
F
R
T
D
M
G
I
ER
T
S
LGSLLDHTG
AF
G
E
S
E
K
Y
A
ARVFGADRS
W
S
V
VV
GTS
G
SN
RTIMQA
C
MT
D
NDV
V
VV
DRNCHKS
I
E
QG
LM
L
T
GA
K
PVY
MV
P
S
RN
R
YGI
I
G
P
I
Y
PQ
E
M
Q
PE
T
L
Q
KK
I
S
E
S
P
LTKDK
V
G
Q
K
P
SYC
V
V
TN
C
TYDG
VC
YN
AK
E
AQ
D
L
L
EK
T
S
DRL
HFD
E
AW
YG
Y
A
R
F
N
PIY
A
DH
Y
A
M
R
GE
--
PGDH
N
G
PTV
F
A
T
H
STHKLL
N
ALSQAS
Y
IHV
REG
-
R
G
AI
N
FS
R
FN
Q
AYMMH
A
TTSP
L
Y
A
I
C
AS
N
DV
A
VS
MM
D
GN
S
G
LS
L
TQ
E
V
I
DE
A
V
D
FR
QA
M
A
---
RL
Y
K
E
FTADGS
WFF
K
P
W
NK
EV
V
T
D
PQTGKTYDFADAPTKLLTTV
Q
D
CW
V
M
H
PGE
S
WHGF
--
KDI
P
D
N
WS
M
LDPIKV
S
IL
A
PGM
G
EDG
E
LE
E
I
G
V
PAALV
TA
W
L
GR
HGIV
PTR
T
TDFQIM
FLFS
M
G
VTRG
K
W
GT
L
VN
T
L
C
S
FKR
H
YD
A
N
TP
L
AQVM
P
E
L
V
E
QY
PD
T
Y
A
NM
G
I
H
DL
GD
T
MFAWL
KE
N
N
PG
A
RL
N
E
A
Y
SG
LP
V
A
E
I
TP
RE
A
Y
N
AI
V
D
N
N
VE
L
V
S
I
E
N
L
P
GRI
A
AN
SVI
PYPPG
I
P
M
L
LS
GE
N
F
G
D
KNS
P
QV
S
Y
L
R
S
L
Q
S
W
D
H
H
F
PGFE
HETE
G
T
EI-I
DG
I
Y
H
V
M
CV
K
fig|199310.1.peg.5015
Escherichia coli CFT073 (22-755/756)
V
E
R
L
AD
AL
SQ
QN
VTV
I
K
S
T
S
F
DD
GFA
I
LS
S
N
E
A
I
DCLM
F
SYQ
M
E
H
P
D
EH
Q
N
V
R
QL
IGKLHERQQ
N
V
P
VFLL
G
DR
E
KA
L
AAM
DR
---
DL
L
E
-----
L
V
D
E
F
AWI
L
ED
T
A
DF
IA
G
R
AV
A
A
M
T
R
Y
RQQ
L
LPPL
FS
AL
M
KY
S
D
I
H
E
Y
SWAA
PGH
Q
GG
VG
F
T
K
T
P
A
G
R
FYH
D
YY
G
E
N
L
F
R
T
D
M
G
I
ER
T
S
LGSLLDHTG
AF
G
E
S
E
K
Y
A
ARVFGADRS
W
S
V
VV
GTS
G
SN
RTIMQA
C
MT
D
NDV
V
VV
DRNCHKS
I
E
QG
LM
L
T
GA
K
PVY
MV
P
S
RN
R
YGI
I
G
P
I
Y
PQ
E
M
Q
PE
T
L
Q
KK
I
S
E
S
P
LTKDK
V
G
Q
K
P
SYC
V
V
TN
C
TYDG
VC
YN
AK
E
AQ
D
L
L
EK
T
S
DRL
HFD
E
AW
YG
Y
A
R
F
N
PIY
A
DH
Y
A
M
R
GE
--
PGDH
N
G
PTV
F
A
T
H
STHKLL
N
ALSQAS
Y
IHV
REG
-
R
G
AI
N
FS
R
FN
Q
AYMMH
A
TTSP
L
Y
A
I
C
AS
N
DV
A
VS
MM
D
GN
S
G
LS
L
TQ
E
V
I
DE
A
V
D
FR
QA
M
A
---
RL
Y
K
E
FTADGS
WFF
K
P
W
NK
EV
V
T
D
PQTGKTYDFADAPTKLLTTV
Q
D
CW
V
M
H
PGE
S
WHGF
--
KDI
P
D
N
WS
M
LDPIKV
S
IL
A
PGM
G
EDG
E
LE
E
I
G
V
PAALV
TA
W
L
GR
HGIV
PTR
T
TDFQIM
FLFS
M
G
VTRG
K
W
GT
L
VN
T
L
C
S
FKR
H
YD
A
N
TP
L
AQVM
P
E
L
V
E
QY
PD
T
Y
A
NM
G
I
H
DL
GD
T
MFAWL
KE
N
N
PG
A
RL
N
E
A
Y
SG
LP
V
A
E
I
TP
RE
A
Y
N
AI
V
D
N
N
VE
L
V
S
I
E
N
L
P
GRI
A
AN
SVI
PYPPG
I
P
M
L
LS
GE
N
F
G
D
KNS
P
QV
S
Y
L
R
S
L
Q
S
W
D
H
H
F
PGFE
HETE
G
T
EI-I
DG
I
Y
H
V
M
CV
K
fig|199310.4.peg.4808
Escherichia coli CFT073 (22-755/756)
V
E
R
L
AD
AL
SQ
QN
VTV
I
K
S
T
S
F
DD
GFA
I
LS
S
N
E
A
I
DCLM
F
SYQ
M
E
H
P
D
EH
Q
N
V
R
QL
IGKLHERQQ
N
V
P
VFLL
G
DR
E
KA
L
AAM
DR
---
DL
L
E
-----
L
V
D
E
F
AWI
L
ED
T
A
DF
IA
G
R
AV
A
A
M
T
R
Y
RQQ
L
LPPL
FS
AL
M
KY
S
D
I
H
E
Y
SWAA
PGH
Q
GG
VG
F
T
K
T
P
A
G
R
FYH
D
YY
G
E
N
L
F
R
T
D
M
G
I
ER
T
S
LGSLLDHTG
AF
G
E
S
E
K
Y
A
ARVFGADRS
W
S
V
VV
GTS
G
SN
RTIMQA
C
MT
D
NDV
V
VV
DRNCHKS
I
E
QG
LM
L
T
GA
K
PVY
MV
P
S
RN
R
YGI
I
G
P
I
Y
PQ
E
M
Q
PE
T
L
Q
KK
I
S
E
S
P
LTKDK
V
G
Q
K
P
SYC
V
V
TN
C
TYDG
VC
YN
AK
E
AQ
D
L
L
EK
T
S
DRL
HFD
E
AW
YG
Y
A
R
F
N
PIY
A
DH
Y
A
M
R
GE
--
PGDH
N
G
PTV
F
A
T
H
STHKLL
N
ALSQAS
Y
IHV
REG
-
R
G
AI
N
FS
R
FN
Q
AYMMH
A
TTSP
L
Y
A
I
C
AS
N
DV
A
VS
MM
D
GN
S
G
LS
L
TQ
E
V
I
DE
A
V
D
FR
QA
M
A
---
RL
Y
K
E
FTADGS
WFF
K
P
W
NK
EV
V
T
D
PQTGKTYDFADAPTKLLTTV
Q
D
CW
V
M
H
PGE
S
WHGF
--
KDI
P
D
N
WS
M
LDPIKV
S
IL
A
PGM
G
EDG
E
LE
E
I
G
V
PAALV
TA
W
L
GR
HGIV
PTR
T
TDFQIM
FLFS
M
G
VTRG
K
W
GT
L
VN
T
L
C
S
FKR
H
YD
A
N
TP
L
AQVM
P
E
L
V
E
QY
PD
T
Y
A
NM
G
I
H
DL
GD
T
MFAWL
KE
N
N
PG
A
RL
N
E
A
Y
SG
LP
V
A
E
I
TP
RE
A
Y
N
AI
V
D
N
N
VE
L
V
S
I
E
N
L
P
GRI
A
AN
SVI
PYPPG
I
P
M
L
LS
GE
N
F
G
D
KNS
P
QV
S
Y
L
R
S
L
Q
S
W
D
H
H
F
PGFE
HETE
G
T
EI-I
DG
I
Y
H
V
M
CV
K
fig|749546.3.peg.1613
Escherichia coli MS 185-1 (22-755/756)
V
E
R
L
AD
AL
SQ
QN
VTV
I
K
S
T
S
F
DD
GFA
I
LS
S
N
E
A
I
DCLM
F
SYQ
M
E
H
P
D
EH
Q
N
V
R
QL
IGKLHERQQ
N
V
P
VFLL
G
DR
E
KA
L
AAM
DR
---
DL
L
E
-----
L
V
D
E
F
AWI
L
ED
T
A
DF
IA
G
R
AV
A
A
M
T
R
Y
RQQ
L
LPPL
FS
AL
M
KY
S
D
I
H
E
Y
SWAA
PGH
Q
GG
VG
F
T
K
T
P
A
G
R
FYH
D
YY
G
E
N
L
F
R
T
D
M
G
I
ER
T
S
LGSLLDHTG
AF
G
E
S
E
K
Y
A
ARVFGADRS
W
S
V
VV
GTS
G
SN
RTIMQA
C
MT
D
NDV
V
VV
DRNCHKS
I
E
QG
LM
L
T
GA
K
PVY
MV
P
S
RN
R
YGI
I
G
P
I
Y
PQ
E
M
Q
PE
T
L
Q
KK
I
S
E
S
P
LTKDK
V
G
Q
K
P
SYC
V
V
TN
C
TYDG
VC
YN
AK
E
AQ
D
L
L
EK
T
S
DRL
HFD
E
AW
YG
Y
A
R
F
N
PIY
A
DH
Y
A
M
R
GE
--
PGDH
N
G
PTV
F
A
T
H
STHKLL
N
ALSQAS
Y
IHV
REG
-
R
G
AI
N
FS
R
FN
Q
AYMMH
A
TTSP
L
Y
A
I
C
AS
N
DV
A
VS
MM
D
GN
S
G
LS
L
TQ
E
V
I
DE
A
V
D
FR
QA
M
A
---
RL
Y
K
E
FTADGS
WFF
K
P
W
NK
EV
V
T
D
PQTGKTYDFADAPTKLLTTV
Q
D
CW
V
M
H
PGE
S
WHGF
--
KDI
P
D
N
WS
M
LDPIKV
S
IL
A
PGM
G
EDG
E
LE
E
I
G
V
PAALV
TA
W
L
GR
HGIV
PTR
T
TDFQIM
FLFS
M
G
VTRG
K
W
GT
L
VN
T
L
C
S
FKR
H
YD
A
N
TP
L
AQVM
P
E
L
V
E
QY
PD
T
Y
A
NM
G
I
H
DL
GD
T
MFAWL
KE
N
N
PG
A
RL
N
E
A
Y
SG
LP
V
A
E
I
TP
RE
A
Y
N
AI
V
D
N
N
VE
L
V
S
I
E
N
L
P
GRI
A
AN
SVI
PYPPG
I
P
M
L
LS
GE
N
F
G
D
KNS
P
QV
S
Y
L
R
S
L
Q
S
W
D
H
H
F
PGFE
HETE
G
T
EI-I
DG
I
Y
H
V
M
CV
K
fig|749528.3.peg.3740
Escherichia coli MS 45-1 (22-755/756)
V
E
R
L
AD
AL
SQ
QN
VTV
I
K
S
T
S
F
DD
GFA
I
LS
S
N
E
A
I
DCLM
F
SYQ
M
E
H
P
D
EH
Q
N
V
R
QL
IGKLHERQQ
N
V
P
VFLL
G
DR
E
KA
L
AAM
DR
---
DL
L
E
-----
L
V
D
E
F
AWI
L
ED
T
A
DF
IA
G
R
AV
A
A
M
T
R
Y
RQQ
L
LPPL
FS
AL
M
KY
S
D
I
H
E
Y
SWAA
PGH
Q
GG
VG
F
T
K
T
P
A
G
R
FYH
D
YY
G
E
N
L
F
R
T
D
M
G
I
ER
T
S
LGSLLDHTG
AF
G
E
S
E
K
Y
A
ARVFGADRS
W
S
V
VV
GTS
G
SN
RTIMQA
C
MT
D
NDV
V
VV
DRNCHKS
I
E
QG
LM
L
T
GA
K
PVY
MV
P
S
RN
R
YGI
I
G
P
I
Y
PQ
E
M
Q
PE
T
L
Q
KK
I
S
E
S
P
LTKDK
V
G
Q
K
P
SYC
V
V
TN
C
TYDG
VC
YN
AK
E
AQ
D
L
L
EK
T
S
DRL
HFD
E
AW
YG
Y
A
R
F
N
PIY
A
DH
Y
A
M
R
GE
--
PGDH
N
G
PTV
F
A
T
H
STHKLL
N
ALSQAS
Y
IHV
REG
-
R
G
AI
N
FS
R
FN
Q
AYMMH
A
TTSP
L
Y
A
I
C
AS
N
DV
A
VS
MM
D
GN
S
G
LS
L
TQ
E
V
I
DE
A
V
D
FR
QA
M
A
---
RL
Y
K
E
FTADGS
WFF
K
P
W
NK
EV
V
T
D
PQTGKTYDFADAPTKLLTTV
Q
D
CW
V
M
H
PGE
S
WHGF
--
KDI
P
D
N
WS
M
LDPIKV
S
IL
A
PGM
G
EDG
E
LE
E
I
G
V
PAALV
TA
W
L
GR
HGIV
PTR
T
TDFQIM
FLFS
M
G
VTRG
K
W
GT
L
VN
T
L
C
S
FKR
H
YD
A
N
TP
L
AQVM
P
E
L
V
E
QY
PD
T
Y
A
NM
G
I
H
DL
GD
T
MFAWL
KE
N
N
PG
A
RL
N
E
A
Y
SG
LP
V
A
E
I
TP
RE
A
Y
N
AI
V
D
N
N
VE
L
V
S
I
E
N
L
P
GRI
A
AN
SVI
PYPPG
I
P
M
L
LS
GE
N
F
G
D
KNS
P
QV
S
Y
L
R
S
L
Q
S
W
D
H
H
F
PGFE
HETE
G
T
EI-I
DG
I
Y
H
V
M
CV
K
fig|656440.3.peg.4690
Escherichia coli TA206 (22-755/756)
V
E
R
L
AD
AL
SQ
QN
VTV
I
K
S
T
S
F
DD
GFA
I
LS
S
N
E
A
I
DCLM
F
SYQ
M
E
H
P
D
EH
Q
N
V
R
QL
IGKLHERQQ
N
V
P
VFLL
G
DR
E
KA
L
AAM
DR
---
DL
L
E
-----
L
V
D
E
F
AWI
L
ED
T
A
DF
IA
G
R
AV
A
A
M
T
R
Y
RQQ
L
LPPL
FS
AL
M
KY
S
D
I
H
E
Y
SWAA
PGH
Q
GG
VG
F
T
K
T
P
A
G
R
FYH
D
YY
G
E
N
L
F
R
T
D
M
G
I
ER
T
S
LGSLLDHTG
AF
G
E
S
E
K
Y
A
ARVFGADRS
W
S
V
VV
GTS
G
SN
RTIMQA
C
MT
D
NDV
V
VV
DRNCHKS
I
E
QG
LM
L
T
GA
K
PVY
MV
P
S
RN
R
YGI
I
G
P
I
Y
PQ
E
M
Q
PE
T
L
Q
KK
I
S
E
S
P
LTKDK
V
G
Q
K
P
SYC
V
V
TN
C
TYDG
VC
YN
AK
E
AQ
D
L
L
EK
T
S
DRL
HFD
E
AW
YG
Y
A
R
F
N
PIY
A
DH
Y
A
M
R
GE
--
PGDH
N
G
PTV
F
A
T
H
STHKLL
N
ALSQAS
Y
IHV
REG
-
R
G
AI
N
FS
R
FN
Q
AYMMH
A
TTSP
L
Y
A
I
C
AS
N
DV
A
VS
MM
D
GN
S
G
LS
L
TQ
E
V
I
DE
A
V
D
FR
QA
M
A
---
RL
Y
K
E
FTADGS
WFF
K
P
W
NK
EV
V
T
D
PQTGKTYDFADAPTKLLTTV
Q
D
CW
V
M
H
PGE
S
WHGF
--
KDI
P
D
N
WS
M
LDPIKV
S
IL
A
PGM
G
EDG
E
LE
E
I
G
V
PAALV
TA
W
L
GR
HGIV
PTR
T
TDFQIM
FLFS
M
G
VTRG
K
W
GT
L
VN
T
L
C
S
FKR
H
YD
A
N
TP
L
AQVM
P
E
L
V
E
QY
PD
T
Y
A
NM
G
I
H
DL
GD
T
MFAWL
KE
N
N
PG
A
RL
N
E
A
Y
SG
LP
V
A
E
I
TP
RE
A
Y
N
AI
V
D
N
N
VE
L
V
S
I
E
N
L
P
GRI
A
AN
SVI
PYPPG
I
P
M
L
LS
GE
N
F
G
D
KNS
P
QV
S
Y
L
R
S
L
Q
S
W
D
H
H
F
PGFE
HETE
G
T
EI-I
DG
I
Y
H
V
M
CV
K
fig|431946.3.peg.4159
Escherichia coli SE15 (22-755/756)
V
E
R
L
AD
AL
SQ
QN
VTV
I
K
S
T
S
F
DD
GFA
I
LS
S
N
E
A
I
DCLM
F
SYQ
M
E
H
P
D
EH
Q
N
V
R
QL
IGKLHERQQ
N
V
P
VFLL
G
DR
E
KA
L
AAM
DR
---
DL
L
E
-----
L
V
D
E
F
AWI
L
ED
T
A
DF
IA
G
R
AV
A
A
M
T
R
Y
RQQ
L
LPPL
FS
AL
M
KY
S
D
I
H
E
Y
SWAA
PGH
Q
GG
VG
F
T
K
T
P
A
G
R
FYH
D
YY
G
E
N
L
F
R
T
D
M
G
I
ER
T
S
LGSLLDHTG
AF
G
E
S
E
K
Y
A
ARVFGADRS
W
S
V
VV
GTS
G
SN
RTIMQA
C
MT
D
NDV
V
VV
DRNCHKS
I
E
QG
LM
L
T
GA
K
PVY
MV
P
S
RN
R
YGI
I
G
P
I
Y
PQ
E
M
Q
PE
T
L
Q
KK
I
N
E
S
P
LTKDK
V
G
Q
K
P
SYC
V
V
TN
C
TYDG
VC
YN
AK
E
AQ
D
L
L
EK
T
S
DRL
HFD
E
AW
YG
Y
A
R
F
N
PIY
A
DH
Y
A
M
R
GE
--
PGDH
N
G
PTV
F
A
T
H
STHKLL
N
ALSQAS
Y
IHV
REG
-
R
G
AI
N
FS
R
FN
Q
AYMMH
A
TTSP
L
Y
A
I
C
AS
N
DV
A
VS
MM
D
GN
S
G
LS
L
TQ
E
V
I
DE
A
V
D
FR
QA
M
A
---
RL
Y
K
E
FTADGS
WFF
K
P
W
NK
EV
V
T
D
PQTGKTYDFADAPTKLLTTV
Q
D
CW
V
M
H
PGE
S
WHGF
--
KDI
P
D
N
WS
M
LDPIKV
S
IL
A
PGM
G
EDG
E
LE
E
T
G
V
PAALV
TA
W
L
GR
HGIV
PTR
T
TDFQIM
FLFS
M
G
VTRG
K
W
GT
L
VN
T
L
C
S
FKR
H
YD
A
N
TP
L
AQVM
P
E
L
V
E
QY
PD
T
Y
A
NM
G
I
H
DL
GD
T
MFAWL
KE
N
N
PG
A
RL
N
E
A
Y
SG
LP
V
A
E
I
TP
RE
A
Y
N
AI
V
D
N
N
VE
L
V
S
I
E
N
L
P
GRI
A
AN
SVI
PYPPG
I
P
M
L
LS
GE
N
F
G
D
KNS
P
QV
S
Y
L
R
S
L
Q
S
W
D
H
H
F
PGFE
HETE
G
T
EI-I
DG
I
Y
H
V
M
CV
K
fig|749547.3.peg.2665
Escherichia coli MS 187-1 (22-755/756)
V
E
R
L
AD
AL
SQ
QN
VTV
I
K
S
T
S
F
DD
GFA
I
LS
S
N
E
A
I
DCLM
F
SYQ
M
E
H
P
D
EH
Q
N
V
R
QL
IGKLHERQQ
N
V
P
VFLL
G
DR
E
KA
L
AAM
DR
---
DL
L
E
-----
L
V
D
E
F
AWI
L
ED
T
A
DF
IA
G
R
AV
A
A
M
T
R
Y
RQQ
L
LPPL
FS
AL
M
KY
S
D
I
H
E
Y
SWAA
PGH
Q
GG
VG
F
T
K
T
P
A
G
R
FYH
D
YY
G
E
N
L
F
R
T
D
M
G
I
ER
T
S
LGSLLDHTG
AF
G
E
S
E
K
Y
A
ARVFGADRS
W
S
V
VV
GTS
G
SN
RTIMQA
C
MT
D
NDV
V
VV
DRNCHKS
I
E
QG
LM
L
T
GA
K
PVY
MV
P
S
RN
R
YGI
I
G
P
I
Y
PQ
E
M
Q
PE
T
L
Q
KK
I
S
E
S
P
LTKDK
A
G
Q
K
P
SYC
V
V
TN
C
TYDG
VC
YN
AK
E
AQ
D
L
L
EK
T
S
DRL
HFD
E
AW
YG
Y
A
R
F
N
PIY
A
DH
Y
A
M
R
GE
--
PGDH
N
G
PTV
F
A
T
H
STHKLL
N
ALSQAS
Y
IHV
REG
-
R
G
AI
N
FS
R
FN
Q
AYMMH
A
TTSP
L
Y
A
I
C
AS
N
DV
A
VS
MM
D
GN
S
G
LS
L
TQ
E
V
I
DE
A
V
D
FR
QA
M
A
---
RL
Y
K
E
FTADGS
WFF
K
P
W
NK
EV
V
T
D
PQTGKTYDFADAPTKLLTTV
Q
D
CW
V
M
H
PGE
S
WHGF
--
KDI
P
D
N
WS
M
LDP
S
KV
S
IL
A
PGM
G
EDG
E
LE
E
T
G
V
PAALV
TA
W
L
GR
HGIV
PTR
T
TDFQIM
FLFS
M
G
VTRG
K
W
GT
L
VN
T
L
C
S
FKR
H
YD
A
N
TP
L
AQVM
P
E
L
V
E
QY
PD
T
Y
A
NM
G
I
H
DL
GD
T
MFAWL
KE
N
N
PG
A
RL
N
E
A
Y
SG
LP
V
A
E
V
TP
RE
A
Y
N
AI
V
D
N
N
VE
L
V
S
I
E
N
L
P
GRI
A
AN
SVI
PYPPG
I
P
M
L
LS
GE
N
F
G
D
KNS
P
QV
S
Y
L
R
S
L
Q
S
W
D
H
H
F
PGFE
HETE
G
T
EI-I
DG
I
Y
H
V
M
CV
K
fig|585397.7.peg.4838
Escherichia coli ED1a (22-755/756)
V
E
R
L
AD
AL
SQ
QN
VTV
I
K
S
T
S
F
DD
GFA
I
LS
S
N
E
A
I
DCLM
F
SYQ
M
E
H
P
D
EH
Q
N
V
R
QL
IGKLHERQQ
N
V
P
VFLL
G
DR
E
KA
L
AAM
DR
---
DL
L
E
-----
L
V
D
E
F
AWI
L
ED
T
A
DF
IA
G
R
AV
A
A
M
T
R
Y
RQQ
L
LPPL
FS
AL
M
KY
S
D
I
H
E
Y
SWAA
PGH
Q
GG
VG
F
T
K
T
P
A
G
R
FYH
D
YY
G
E
N
L
F
R
T
D
M
G
I
ER
T
S
LGSLLDHTG
AF
G
E
S
E
R
Y
A
ARVFGADRS
W
S
V
VV
GTS
G
SN
RTIMQA
C
MT
D
NDV
V
VV
DRNCHKS
I
E
QG
LM
L
T
GA
K
PVY
MV
P
S
RN
R
YGI
I
G
P
I
Y
PQ
E
M
Q
PE
T
L
Q
KK
I
S
E
S
P
LTKDK
A
G
Q
K
P
SYC
V
V
TN
C
TYDG
VC
YN
AK
E
AQ
D
L
L
EK
T
S
DRL
HFD
E
AW
YG
Y
A
R
F
N
PIY
A
DH
Y
A
M
R
GE
--
PGDH
N
G
PTV
F
A
T
H
S
P
HKLL
N
ALSQAS
Y
IHV
REG
-
R
G
AI
N
FS
R
FN
Q
AYMMH
A
TTSP
L
Y
A
I
C
AS
N
DV
A
VS
MM
D
GN
S
G
LS
L
TQ
E
V
I
DE
A
V
D
FR
QA
M
A
---
RL
Y
K
E
FTADGS
WFF
K
P
W
NK
EV
V
T
D
PQTGKTYDFADAPTKLLTTV
Q
D
CW
V
M
H
PGE
S
WHGF
--
KDI
P
D
N
WS
M
LDPIKV
S
IL
A
PGM
G
EDG
E
LE
E
T
G
V
PAALV
TA
W
L
GR
HGIV
PTR
T
TDFQIM
FLFS
M
G
VTRG
K
W
GT
L
VN
T
L
C
S
FKR
H
YD
A
N
TP
L
AQVM
P
E
L
V
E
QY
PD
T
Y
A
NM
G
I
H
DL
GD
T
MFAWL
KE
N
N
PG
A
RL
N
E
A
Y
SG
LP
V
A
E
I
TP
RE
A
Y
N
AI
V
D
N
N
VE
L
I
S
I
E
N
L
P
GRI
A
AN
SVI
PYPPG
I
P
M
L
LS
GE
N
F
G
D
KNS
P
QV
S
Y
L
R
S
L
Q
S
W
D
H
H
F
PGFE
HETE
G
T
EI-I
DG
I
Y
H
V
M
CV
K
fig|585397.9.peg.4838
Escherichia coli ED1a (22-755/756)
V
E
R
L
AD
AL
SQ
QN
VTV
I
K
S
T
S
F
DD
GFA
I
LS
S
N
E
A
I
DCLM
F
SYQ
M
E
H
P
D
EH
Q
N
V
R
QL
IGKLHERQQ
N
V
P
VFLL
G
DR
E
KA
L
AAM
DR
---
DL
L
E
-----
L
V
D
E
F
AWI
L
ED
T
A
DF
IA
G
R
AV
A
A
M
T
R
Y
RQQ
L
LPPL
FS
AL
M
KY
S
D
I
H
E
Y
SWAA
PGH
Q
GG
VG
F
T
K
T
P
A
G
R
FYH
D
YY
G
E
N
L
F
R
T
D
M
G
I
ER
T
S
LGSLLDHTG
AF
G
E
S
E
R
Y
A
ARVFGADRS
W
S
V
VV
GTS
G
SN
RTIMQA
C
MT
D
NDV
V
VV
DRNCHKS
I
E
QG
LM
L
T
GA
K
PVY
MV
P
S
RN
R
YGI
I
G
P
I
Y
PQ
E
M
Q
PE
T
L
Q
KK
I
S
E
S
P
LTKDK
A
G
Q
K
P
SYC
V
V
TN
C
TYDG
VC
YN
AK
E
AQ
D
L
L
EK
T
S
DRL
HFD
E
AW
YG
Y
A
R
F
N
PIY
A
DH
Y
A
M
R
GE
--
PGDH
N
G
PTV
F
A
T
H
S
P
HKLL
N
ALSQAS
Y
IHV
REG
-
R
G
AI
N
FS
R
FN
Q
AYMMH
A
TTSP
L
Y
A
I
C
AS
N
DV
A
VS
MM
D
GN
S
G
LS
L
TQ
E
V
I
DE
A
V
D
FR
QA
M
A
---
RL
Y
K
E
FTADGS
WFF
K
P
W
NK
EV
V
T
D
PQTGKTYDFADAPTKLLTTV
Q
D
CW
V
M
H
PGE
S
WHGF
--
KDI
P
D
N
WS
M
LDPIKV
S
IL
A
PGM
G
EDG
E
LE
E
T
G
V
PAALV
TA
W
L
GR
HGIV
PTR
T
TDFQIM
FLFS
M
G
VTRG
K
W
GT
L
VN
T
L
C
S
FKR
H
YD
A
N
TP
L
AQVM
P
E
L
V
E
QY
PD
T
Y
A
NM
G
I
H
DL
GD
T
MFAWL
KE
N
N
PG
A
RL
N
E
A
Y
SG
LP
V
A
E
I
TP
RE
A
Y
N
AI
V
D
N
N
VE
L
I
S
I
E
N
L
P
GRI
A
AN
SVI
PYPPG
I
P
M
L
LS
GE
N
F
G
D
KNS
P
QV
S
Y
L
R
S
L
Q
S
W
D
H
H
F
PGFE
HETE
G
T
EI-I
DG
I
Y
H
V
M
CV
K
fig|362663.8.peg.4394
Escherichia coli 536 (22-755/756)
V
E
R
L
AD
AL
SQ
QN
VTV
I
K
S
T
S
F
DD
GFA
I
LS
S
N
E
A
I
DCLM
F
SYQ
M
E
H
P
D
EH
Q
N
V
R
QL
IGKLHERQQ
N
V
P
VFLL
G
DR
E
KA
L
AAM
DR
---
DL
L
E
-----
L
V
D
E
F
AWI
L
ED
T
A
DF
IA
G
R
AV
A
A
M
T
R
Y
RQQ
L
LPPL
FS
AL
M
KY
S
D
I
H
E
Y
SWAA
PGH
Q
GG
VG
F
T
K
T
P
A
G
R
FYH
D
YY
G
E
N
L
F
R
T
D
M
G
I
ER
T
S
LGSLLDHTG
AF
G
E
S
E
R
Y
A
ARVFGADRS
W
S
V
VV
GTS
G
SN
RTIMQA
C
MT
D
NDV
V
VV
DRNCHKS
I
E
QG
LM
L
T
GA
K
PVY
MV
P
S
RN
R
YGI
I
G
P
I
Y
PQ
E
M
Q
PE
T
L
Q
KK
I
S
E
S
P
LTKDK
V
G
Q
K
P
SYC
V
V
TN
C
TYDG
VC
YN
AK
E
AQ
D
L
L
EK
T
S
DRL
HFD
E
AW
YG
Y
A
R
F
N
PIY
A
DH
Y
A
M
R
GE
--
PGDH
N
G
PTV
F
A
T
H
STHKLL
N
ALSQAS
Y
IHV
REG
-
R
G
AI
N
FS
R
FN
Q
AYMMH
A
TTSP
L
Y
A
I
C
AS
N
DV
A
VS
MM
D
GN
S
G
LS
L
TQ
E
V
I
DE
A
V
D
FR
QA
M
A
---
RL
Y
K
E
FTADGS
WFF
K
P
W
NK
EV
V
T
D
PQTGKTYDFADAPTKLLTTV
Q
D
CW
V
M
H
PGE
S
WHGF
--
KDI
P
D
N
WS
M
LDPIKV
S
IL
A
PGM
G
EDG
E
LE
E
T
G
V
PAALV
TA
W
L
GR
HGIV
PTR
T
TDFQIM
FLFS
M
G
VTRG
K
W
GT
L
VN
T
L
C
S
FKR
H
YD
A
N
TP
L
AQVM
P
E
L
V
E
QY
PD
T
Y
A
N
I
G
I
H
DL
GD
T
MFAWL
KE
N
N
PG
A
RL
N
E
A
Y
SG
LP
V
A
E
I
TP
RE
A
Y
N
AI
V
D
N
N
VE
L
V
S
I
E
N
L
P
GRI
A
AN
SVI
PYPPG
I
P
M
L
LS
GE
N
F
G
D
KNS
P
QV
S
Y
L
R
S
L
Q
S
W
D
H
H
F
PGFE
HETE
G
T
EI-I
DG
I
Y
H
V
M
CV
K
fig|362663.9.peg.4410
Escherichia coli 536 (22-755/756)
V
E
R
L
AD
AL
SQ
QN
VTV
I
K
S
T
S
F
DD
GFA
I
LS
S
N
E
A
I
DCLM
F
SYQ
M
E
H
P
D
EH
Q
N
V
R
QL
IGKLHERQQ
N
V
P
VFLL
G
DR
E
KA
L
AAM
DR
---
DL
L
E
-----
L
V
D
E
F
AWI
L
ED
T
A
DF
IA
G
R
AV
A
A
M
T
R
Y
RQQ
L
LPPL
FS
AL
M
KY
S
D
I
H
E
Y
SWAA
PGH
Q
GG
VG
F
T
K
T
P
A
G
R
FYH
D
YY
G
E
N
L
F
R
T
D
M
G
I
ER
T
S
LGSLLDHTG
AF
G
E
S
E
R
Y
A
ARVFGADRS
W
S
V
VV
GTS
G
SN
RTIMQA
C
MT
D
NDV
V
VV
DRNCHKS
I
E
QG
LM
L
T
GA
K
PVY
MV
P
S
RN
R
YGI
I
G
P
I
Y
PQ
E
M
Q
PE
T
L
Q
KK
I
S
E
S
P
LTKDK
V
G
Q
K
P
SYC
V
V
TN
C
TYDG
VC
YN
AK
E
AQ
D
L
L
EK
T
S
DRL
HFD
E
AW
YG
Y
A
R
F
N
PIY
A
DH
Y
A
M
R
GE
--
PGDH
N
G
PTV
F
A
T
H
STHKLL
N
ALSQAS
Y
IHV
REG
-
R
G
AI
N
FS
R
FN
Q
AYMMH
A
TTSP
L
Y
A
I
C
AS
N
DV
A
VS
MM
D
GN
S
G
LS
L
TQ
E
V
I
DE
A
V
D
FR
QA
M
A
---
RL
Y
K
E
FTADGS
WFF
K
P
W
NK
EV
V
T
D
PQTGKTYDFADAPTKLLTTV
Q
D
CW
V
M
H
PGE
S
WHGF
--
KDI
P
D
N
WS
M
LDPIKV
S
IL
A
PGM
G
EDG
E
LE
E
T
G
V
PAALV
TA
W
L
GR
HGIV
PTR
T
TDFQIM
FLFS
M
G
VTRG
K
W
GT
L
VN
T
L
C
S
FKR
H
YD
A
N
TP
L
AQVM
P
E
L
V
E
QY
PD
T
Y
A
N
I
G
I
H
DL
GD
T
MFAWL
KE
N
N
PG
A
RL
N
E
A
Y
SG
LP
V
A
E
I
TP
RE
A
Y
N
AI
V
D
N
N
VE
L
V
S
I
E
N
L
P
GRI
A
AN
SVI
PYPPG
I
P
M
L
LS
GE
N
F
G
D
KNS
P
QV
S
Y
L
R
S
L
Q
S
W
D
H
H
F
PGFE
HETE
G
T
EI-I
DG
I
Y
H
V
M
CV
K
fig|405955.13.peg.4620
Escherichia coli APEC O1 (22-755/756)
V
E
R
L
AD
AL
SQ
QN
VTV
I
K
S
T
S
F
DD
GFA
I
LS
S
N
E
A
I
DCLM
F
SYQ
M
E
H
P
D
EH
Q
N
V
R
QL
IGKLHERQQ
N
V
P
VFLL
G
DR
E
KA
L
AAM
DR
---
DL
L
E
-----
L
V
D
E
F
AWI
L
ED
T
A
DF
IA
G
R
AV
A
A
M
T
R
Y
RQQ
L
LPPL
FS
AL
M
KY
S
D
I
H
E
Y
SWAA
PGH
Q
GG
VG
F
T
K
T
P
A
G
R
FYH
D
YY
G
E
N
L
F
R
T
D
M
G
I
ER
T
S
LGSLLDHTG
AF
G
E
S
E
R
Y
A
ARVFGADRS
W
S
V
VV
GTS
G
SN
RTIMQA
C
MT
D
NDV
V
VV
DRNCHKS
I
E
QG
LM
L
T
GA
K
PVY
MV
P
S
RN
R
YGI
I
G
P
I
Y
PQ
E
M
Q
PE
T
L
Q
KK
I
S
E
S
P
LTKDK
V
G
Q
K
P
SYC
V
V
TN
C
TYDG
VC
YN
AK
E
AQ
D
L
L
EK
T
S
DRL
HFD
E
AW
YG
Y
A
R
F
N
PIY
A
DH
Y
A
M
R
GE
--
PGDH
N
G
PTV
F
A
T
H
STHKLL
N
ALSQAS
Y
IHV
REG
-
R
G
AI
N
FS
R
FN
Q
AYMMH
A
TTSP
L
Y
A
I
C
AS
N
DV
A
VS
MM
D
GN
S
G
LS
L
TQ
E
V
I
DE
A
V
D
FR
QA
M
A
---
RL
Y
K
E
FTADGS
WFF
K
P
W
NK
EV
V
T
D
PQTGKTYDFADAPTKLLTTV
Q
D
CW
V
M
H
PGE
S
WHGF
--
KDI
P
D
N
WS
M
LDPIKV
S
IL
A
PGM
G
EDG
E
LE
E
T
G
V
PAALV
TA
W
L
GR
HGIV
PTR
T
TDFQIM
FLFS
M
G
VTRG
K
W
GT
L
VN
T
L
C
S
FKR
H
YD
A
N
TP
L
AQVM
P
E
L
V
E
QY
PD
T
Y
A
N
I
G
I
H
DL
GD
T
MFAWL
KE
N
N
PG
A
RL
N
E
A
Y
SG
LP
V
A
E
I
TP
RE
A
Y
N
AI
V
D
N
N
VE
L
V
S
I
E
N
L
P
GRI
A
AN
SVI
PYPPG
I
P
M
L
LS
GE
N
F
G
D
KNS
P
QV
S
Y
L
R
S
L
Q
S
W
D
H
H
F
PGFE
HETE
G
T
EI-I
DG
I
Y
H
V
M
CV
K
fig|405955.9.peg.3906
Escherichia coli APEC O1 (22-755/756)
V
E
R
L
AD
AL
SQ
QN
VTV
I
K
S
T
S
F
DD
GFA
I
LS
S
N
E
A
I
DCLM
F
SYQ
M
E
H
P
D
EH
Q
N
V
R
QL
IGKLHERQQ
N
V
P
VFLL
G
DR
E
KA
L
AAM
DR
---
DL
L
E
-----
L
V
D
E
F
AWI
L
ED
T
A
DF
IA
G
R
AV
A
A
M
T
R
Y
RQQ
L
LPPL
FS
AL
M
KY
S
D
I
H
E
Y
SWAA
PGH
Q
GG
VG
F
T
K
T
P
A
G
R
FYH
D
YY
G
E
N
L
F
R
T
D
M
G
I
ER
T
S
LGSLLDHTG
AF
G
E
S
E
R
Y
A
ARVFGADRS
W
S
V
VV
GTS
G
SN
RTIMQA
C
MT
D
NDV
V
VV
DRNCHKS
I
E
QG
LM
L
T
GA
K
PVY
MV
P
S
RN
R
YGI
I
G
P
I
Y
PQ
E
M
Q
PE
T
L
Q
KK
I
S
E
S
P
LTKDK
V
G
Q
K
P
SYC
V
V
TN
C
TYDG
VC
YN
AK
E
AQ
D
L
L
EK
T
S
DRL
HFD
E
AW
YG
Y
A
R
F
N
PIY
A
DH
Y
A
M
R
GE
--
PGDH
N
G
PTV
F
A
T
H
STHKLL
N
ALSQAS
Y
IHV
REG
-
R
G
AI
N
FS
R
FN
Q
AYMMH
A
TTSP
L
Y
A
I
C
AS
N
DV
A
VS
MM
D
GN
S
G
LS
L
TQ
E
V
I
DE
A
V
D
FR
QA
M
A
---
RL
Y
K
E
FTADGS
WFF
K
P
W
NK
EV
V
T
D
PQTGKTYDFADAPTKLLTTV
Q
D
CW
V
M
H
PGE
S
WHGF
--
KDI
P
D
N
WS
M
LDPIKV
S
IL
A
PGM
G
EDG
E
LE
E
T
G
V
PAALV
TA
W
L
GR
HGIV
PTR
T
TDFQIM
FLFS
M
G
VTRG
K
W
GT
L
VN
T
L
C
S
FKR
H
YD
A
N
TP
L
AQVM
P
E
L
V
E
QY
PD
T
Y
A
N
I
G
I
H
DL
GD
T
MFAWL
KE
N
N
PG
A
RL
N
E
A
Y
SG
LP
V
A
E
I
TP
RE
A
Y
N
AI
V
D
N
N
VE
L
V
S
I
E
N
L
P
GRI
A
AN
SVI
PYPPG
I
P
M
L
LS
GE
N
F
G
D
KNS
P
QV
S
Y
L
R
S
L
Q
S
W
D
H
H
F
PGFE
HETE
G
T
EI-I
DG
I
Y
H
V
M
CV
K
fig|340197.3.peg.3467
Escherichia coli F11 (22-755/756)
V
E
R
L
AD
AL
SQ
QN
VTV
I
K
S
T
S
F
DD
GFA
I
LS
S
N
E
A
I
DCLM
F
SYQ
M
E
H
P
D
EH
Q
N
V
R
QL
IGKLHERQQ
N
V
P
VFLL
G
DR
E
KA
L
AAM
DR
---
DL
L
E
-----
L
V
D
E
F
AWI
L
ED
T
A
DF
IA
G
R
AV
A
A
M
T
R
Y
RQQ
L
LPPL
FS
AL
M
KY
S
D
I
H
E
Y
SWAA
PGH
Q
GG
VG
F
T
K
T
P
A
G
R
FYH
D
YY
G
E
N
L
F
R
T
D
M
G
I
ER
T
S
LGSLLDHTG
AF
G
E
S
E
R
Y
A
ARVFGADRS
W
S
V
VV
GTS
G
SN
RTIMQA
C
MT
D
NDV
V
VV
DRNCHKS
I
E
QG
LM
L
T
GA
K
PVY
MV
P
S
RN
R
YGI
I
G
P
I
Y
PQ
E
M
Q
PE
T
L
Q
KK
I
S
E
S
P
LTKDK
V
G
Q
K
P
SYC
V
V
TN
C
TYDG
VC
YN
AK
E
AQ
D
L
L
EK
T
S
DRL
HFD
E
AW
YG
Y
A
R
F
N
PIY
A
DH
Y
A
M
R
GE
--
PGDH
N
G
PTV
F
A
T
H
STHKLL
N
ALSQAS
Y
IHV
REG
-
R
G
AI
N
FS
R
FN
Q
AYMMH
A
TTSP
L
Y
A
I
C
AS
N
DV
A
VS
MM
D
GN
S
G
LS
L
TQ
E
V
I
DE
A
V
D
FR
QA
M
A
---
RL
Y
K
E
FTADGS
WFF
K
P
W
NK
EV
V
T
D
PQTGKTYDFADAPTKLLTTV
Q
D
CW
V
M
H
PGE
S
WHGF
--
KDI
P
D
N
WS
M
LDPIKV
S
IL
A
PGM
G
EDG
E
LE
E
T
G
V
PAALV
TA
W
L
GR
HGIV
PTR
T
TDFQIM
FLFS
M
G
VTRG
K
W
GT
L
VN
T
L
C
S
FKR
H
YD
A
N
TP
L
AQVM
P
E
L
V
E
QY
PD
T
Y
A
N
I
G
I
H
DL
GD
T
MFAWL
KE
N
N
PG
A
RL
N
E
A
Y
SG
LP
V
A
E
I
TP
RE
A
Y
N
AI
V
D
N
N
VE
L
V
S
I
E
N
L
P
GRI
A
AN
SVI
PYPPG
I
P
M
L
LS
GE
N
F
G
D
KNS
P
QV
S
Y
L
R
S
L
Q
S
W
D
H
H
F
PGFE
HETE
G
T
EI-I
DG
I
Y
H
V
M
CV
K
fig|340197.5.peg.3634
Escherichia coli F11 (22-755/756)
V
E
R
L
AD
AL
SQ
QN
VTV
I
K
S
T
S
F
DD
GFA
I
LS
S
N
E
A
I
DCLM
F
SYQ
M
E
H
P
D
EH
Q
N
V
R
QL
IGKLHERQQ
N
V
P
VFLL
G
DR
E
KA
L
AAM
DR
---
DL
L
E
-----
L
V
D
E
F
AWI
L
ED
T
A
DF
IA
G
R
AV
A
A
M
T
R
Y
RQQ
L
LPPL
FS
AL
M
KY
S
D
I
H
E
Y
SWAA
PGH
Q
GG
VG
F
T
K
T
P
A
G
R
FYH
D
YY
G
E
N
L
F
R
T
D
M
G
I
ER
T
S
LGSLLDHTG
AF
G
E
S
E
R
Y
A
ARVFGADRS
W
S
V
VV
GTS
G
SN
RTIMQA
C
MT
D
NDV
V
VV
DRNCHKS
I
E
QG
LM
L
T
GA
K
PVY
MV
P
S
RN
R
YGI
I
G
P
I
Y
PQ
E
M
Q
PE
T
L
Q
KK
I
S
E
S
P
LTKDK
V
G
Q
K
P
SYC
V
V
TN
C
TYDG
VC
YN
AK
E
AQ
D
L
L
EK
T
S
DRL
HFD
E
AW
YG
Y
A
R
F
N
PIY
A
DH
Y
A
M
R
GE
--
PGDH
N
G
PTV
F
A
T
H
STHKLL
N
ALSQAS
Y
IHV
REG
-
R
G
AI
N
FS
R
FN
Q
AYMMH
A
TTSP
L
Y
A
I
C
AS
N
DV
A
VS
MM
D
GN
S
G
LS
L
TQ
E
V
I
DE
A
V
D
FR
QA
M
A
---
RL
Y
K
E
FTADGS
WFF
K
P
W
NK
EV
V
T
D
PQTGKTYDFADAPTKLLTTV
Q
D
CW
V
M
H
PGE
S
WHGF
--
KDI
P
D
N
WS
M
LDPIKV
S
IL
A
PGM
G
EDG
E
LE
E
T
G
V
PAALV
TA
W
L
GR
HGIV
PTR
T
TDFQIM
FLFS
M
G
VTRG
K
W
GT
L
VN
T
L
C
S
FKR
H
YD
A
N
TP
L
AQVM
P
E
L
V
E
QY
PD
T
Y
A
N
I
G
I
H
DL
GD
T
MFAWL
KE
N
N
PG
A
RL
N
E
A
Y
SG
LP
V
A
E
I
TP
RE
A
Y
N
AI
V
D
N
N
VE
L
V
S
I
E
N
L
P
GRI
A
AN
SVI
PYPPG
I
P
M
L
LS
GE
N
F
G
D
KNS
P
QV
S
Y
L
R
S
L
Q
S
W
D
H
H
F
PGFE
HETE
G
T
EI-I
DG
I
Y
H
V
M
CV
K
fig|749550.3.peg.4437
Escherichia coli MS 200-1 (22-755/756)
V
E
R
L
AD
AL
SQ
QN
VTV
I
K
S
T
S
F
DD
GFA
I
LS
S
N
E
A
I
DCLM
F
SYQ
M
E
H
P
D
EH
Q
N
V
R
QL
IGKLHERQQ
N
V
P
VFLL
G
DR
E
KA
L
AAM
DR
---
DL
L
E
-----
L
V
D
E
F
AWI
L
ED
T
A
DF
IA
G
R
AV
A
A
M
T
R
Y
RQQ
L
LPPL
FS
AL
M
KY
S
D
I
H
E
Y
SWAA
PGH
Q
GG
VG
F
T
K
T
P
A
G
R
FYH
D
YY
G
E
N
L
F
R
T
D
M
G
I
ER
T
S
LGSLLDHTG
AF
G
E
S
E
R
Y
A
ARVFGADRS
W
S
V
VV
GTS
G
SN
RTIMQA
C
MT
D
NDV
V
VV
DRNCHKS
I
E
QG
LM
L
T
GA
K
PVY
MV
P
S
RN
R
YGI
I
G
P
I
Y
PQ
E
M
Q
PE
T
L
Q
KK
I
S
E
S
P
LTKDK
V
G
Q
K
P
SYC
V
V
TN
C
TYDG
VC
YN
AK
E
AQ
D
L
L
EK
T
S
DRL
HFD
E
AW
YG
Y
A
R
F
N
PIY
A
DH
Y
A
M
R
GE
--
PGDH
N
G
PTV
F
A
T
H
STHKLL
N
ALSQAS
Y
IHV
REG
-
R
G
AI
N
FS
R
FN
Q
AYMMH
A
TTSP
L
Y
A
I
C
AS
N
DV
A
VS
MM
D
GN
S
G
LS
L
TQ
E
V
I
DE
A
V
D
FR
QA
M
A
---
RL
Y
K
E
FTADGS
WFF
K
P
W
NK
EV
V
T
D
PQTGKTYDFADAPTKLLTTV
Q
D
CW
V
M
H
PGE
S
WHGF
--
KDI
P
D
N
WS
M
LDPIKV
S
IL
A
PGM
G
EDG
E
LE
E
T
G
V
PAALV
TA
W
L
GR
HGIV
PTR
T
TDFQIM
FLFS
M
G
VTRG
K
W
GT
L
VN
T
L
C
S
FKR
H
YD
A
N
TP
L
AQVM
P
E
L
V
E
QY
PD
T
Y
A
N
I
G
I
H
DL
GD
T
MFAWL
KE
N
N
PG
A
RL
N
E
A
Y
SG
LP
V
A
E
I
TP
RE
A
Y
N
AI
V
D
N
N
VE
L
V
S
I
E
N
L
P
GRI
A
AN
SVI
PYPPG
I
P
M
L
LS
GE
N
F
G
D
KNS
P
QV
S
Y
L
R
S
L
Q
S
W
D
H
H
F
PGFE
HETE
G
T
EI-I
DG
I
Y
H
V
M
CV
K
fig|585035.6.peg.4519
Escherichia coli S88 (22-755/756)
V
E
R
L
AD
AL
SQ
QN
VTV
I
K
S
T
S
F
DD
GFA
I
LS
S
N
E
A
I
DCLM
F
SYQ
M
E
H
P
D
EH
Q
N
V
R
QL
IGKLHERQQ
N
V
P
VFLL
G
DR
E
KA
L
AAM
DR
---
DL
L
E
-----
L
V
D
E
F
AWI
L
ED
T
A
DF
IA
G
R
AV
A
A
M
T
R
Y
RQQ
L
LPPL
FS
AL
M
KY
S
D
I
H
E
Y
SWAA
PGH
Q
GG
VG
F
T
K
T
P
A
G
R
FYH
D
YY
G
E
N
L
F
R
T
D
M
G
I
ER
T
S
LGSLLDHTG
AF
G
E
S
E
R
Y
A
ARVFGADRS
W
S
V
VV
GTS
G
SN
RTIMQA
C
MT
D
NDV
V
VV
DRNCHKS
I
E
QG
LM
L
T
GA
K
PVY
MV
P
S
RN
R
YGI
I
G
P
I
Y
PQ
E
M
Q
PE
T
L
Q
KK
I
S
E
S
P
LTKDK
V
G
Q
K
P
SYC
V
V
TN
C
TYDG
VC
YN
AK
E
AQ
D
L
L
EK
T
S
DRL
HFD
E
AW
YG
Y
A
R
F
N
PIY
A
DH
Y
A
M
R
GE
--
PGDH
N
G
PTV
F
A
T
H
STHKLL
N
ALSQAS
Y
IHV
REG
-
R
G
AI
N
FS
R
FN
Q
AYMMH
A
TTSP
L
Y
A
I
C
AS
N
DV
A
VS
MM
D
GN
S
G
LS
L
TQ
E
V
I
DE
A
V
D
FR
QA
M
A
---
RL
Y
K
E
FTADGS
WFF
K
P
W
NK
EV
V
T
D
PQTGKTYDFADAPTKLLTTV
Q
D
CW
V
M
H
PGE
S
WHGF
--
KDI
P
D
N
WS
M
LDPIKV
S
IL
A
PGM
G
EDG
E
LE
E
T
G
V
PAALV
TA
W
L
GR
HGIV
PTR
T
TDFQIM
FLFS
M
G
VTRG
K
W
GT
L
VN
T
L
C
S
FKR
H
YD
A
N
TP
L
AQVM
P
E
L
V
E
QY
PD
T
Y
A
N
I
G
I
H
DL
GD
T
MFAWL
KE
N
N
PG
A
RL
N
E
A
Y
SG
LP
V
A
E
I
TP
RE
A
Y
N
AI
V
D
N
N
VE
L
V
S
I
E
N
L
P
GRI
A
AN
SVI
PYPPG
I
P
M
L
LS
GE
N
F
G
D
KNS
P
QV
S
Y
L
R
S
L
Q
S
W
D
H
H
F
PGFE
HETE
G
T
EI-I
DG
I
Y
H
V
M
CV
K
fig|869729.3.peg.4470
Escherichia coli UM146 (22-755/756)
V
E
R
L
AD
AL
SQ
QN
VTV
I
K
S
T
S
F
DD
GFA
I
LS
S
N
E
A
I
DCLM
F
SYQ
M
E
H
P
D
EH
Q
N
V
R
QL
IGKLHERQQ
N
V
P
VFLL
G
DR
E
KA
L
AAM
DR
---
DL
L
E
-----
L
V
D
E
F
AWI
L
ED
T
A
DF
IA
G
R
AV
A
A
M
T
R
Y
RQQ
L
LPPL
FS
AL
M
KY
S
D
I
H
E
Y
SWAA
PGH
Q
GG
VG
F
T
K
T
P
A
G
R
FYH
D
YY
G
E
N
L
F
R
T
D
M
G
I
ER
T
S
LGSLLDHTG
AF
G
E
S
E
R
Y
A
ARVFGADRS
W
S
V
VV
GTS
G
SN
RTIMQA
C
MT
D
NDV
V
VV
DRNCHKS
I
E
QG
LM
L
T
GA
K
PVY
MV
P
S
RN
R
YGI
I
G
P
I
Y
PQ
E
M
Q
PE
T
L
Q
KK
I
S
E
S
P
LTKDK
V
G
Q
K
P
SYC
V
V
TN
C
TYDG
VC
YN
AK
E
AQ
D
L
L
EK
T
S
DRL
HFD
E
AW
YG
Y
A
R
F
N
PIY
A
DH
Y
A
M
R
GE
--
PGDH
N
G
PTV
F
A
T
H
STHKLL
N
ALSQAS
Y
IHV
REG
-
R
G
AI
N
FS
R
FN
Q
AYMMH
A
TTSP
L
Y
A
I
C
AS
N
DV
A
VS
MM
D
GN
S
G
LS
L
TQ
E
V
I
DE
A
V
D
FR
QA
M
A
---
RL
Y
K
E
FTADGS
WFF
K
P
W
NK
EV
V
T
D
PQTGKTYDFADAPTKLLTTV
Q
D
CW
V
M
H
PGE
S
WHGF
--
KDI
P
D
N
WS
M
LDPIKV
S
IL
A
PGM
G
EDG
E
LE
E
T
G
V
PAALV
TA
W
L
GR
HGIV
PTR
T
TDFQIM
FLFS
M
G
VTRG
K
W
GT
L
VN
T
L
C
S
FKR
H
YD
A
N
TP
L
AQVM
P
E
L
V
E
QY
PD
T
Y
A
N
I
G
I
H
DL
GD
T
MFAWL
KE
N
N
PG
A
RL
N
E
A
Y
SG
LP
V
A
E
I
TP
RE
A
Y
N
AI
V
D
N
N
VE
L
V
S
I
E
N
L
P
GRI
A
AN
SVI
PYPPG
I
P
M
L
LS
GE
N
F
G
D
KNS
P
QV
S
Y
L
R
S
L
Q
S
W
D
H
H
F
PGFE
HETE
G
T
EI-I
DG
I
Y
H
V
M
CV
K
fig|364106.7.peg.4593
Escherichia coli UTI89 (22-755/756)
V
E
R
L
AD
AL
SQ
QN
VTV
I
K
S
T
S
F
DD
GFA
I
LS
S
N
E
A
I
DCLM
F
SYQ
M
E
H
P
D
EH
Q
N
V
R
QL
IGKLHERQQ
N
V
P
VFLL
G
DR
E
KA
L
AAM
DR
---
DL
L
E
-----
L
V
D
E
F
AWI
L
ED
T
A
DF
IA
G
R
AV
A
A
M
T
R
Y
RQQ
L
LPPL
FS
AL
M
KY
S
D
I
H
E
Y
SWAA
PGH
Q
GG
VG
F
T
K
T
P
A
G
R
FYH
D
YY
G
E
N
L
F
R
T
D
M
G
I
ER
T
S
LGSLLDHTG
AF
G
E
S
E
R
Y
A
ARVFGADRS
W
S
V
VV
GTS
G
SN
RTIMQA
C
MT
D
NDV
V
VV
DRNCHKS
I
E
QG
LM
L
T
GA
K
PVY
MV
P
S
RN
R
YGI
I
G
P
I
Y
PQ
E
M
Q
PE
T
L
Q
KK
I
S
E
S
P
LTKDK
V
G
Q
K
P
SYC
V
V
TN
C
TYDG
VC
YN
AK
E
AQ
D
L
L
EK
T
S
DRL
HFD
E
AW
YG
Y
A
R
F
N
PIY
A
DH
Y
A
M
R
GE
--
PGDH
N
G
PTV
F
A
T
H
STHKLL
N
ALSQAS
Y
IHV
REG
-
R
G
AI
N
FS
R
FN
Q
AYMMH
A
TTSP
L
Y
A
I
C
AS
N
DV
A
VS
MM
D
GN
S
G
LS
L
TQ
E
V
I
DE
A
V
D
FR
QA
M
A
---
RL
Y
K
E
FTADGS
WFF
K
P
W
NK
EV
V
T
D
PQTGKTYDFADAPTKLLTTV
Q
D
CW
V
M
H
PGE
S
WHGF
--
KDI
P
D
N
WS
M
LDPIKV
S
IL
A
PGM
G
EDG
E
LE
E
T
G
V
PAALV
TA
W
L
GR
HGIV
PTR
T
TDFQIM
FLFS
M
G
VTRG
K
W
GT
L
VN
T
L
C
S
FKR
H
YD
A
N
TP
L
AQVM
P
E
L
V
E
QY
PD
T
Y
A
N
I
G
I
H
DL
GD
T
MFAWL
KE
N
N
PG
A
RL
N
E
A
Y
SG
LP
V
A
E
I
TP
RE
A
Y
N
AI
V
D
N
N
VE
L
V
S
I
E
N
L
P
GRI
A
AN
SVI
PYPPG
I
P
M
L
LS
GE
N
F
G
D
KNS
P
QV
S
Y
L
R
S
L
Q
S
W
D
H
H
F
PGFE
HETE
G
T
EI-I
DG
I
Y
H
V
M
CV
K
fig|364106.8.peg.4592
Escherichia coli UTI89 (22-755/756)
V
E
R
L
AD
AL
SQ
QN
VTV
I
K
S
T
S
F
DD
GFA
I
LS
S
N
E
A
I
DCLM
F
SYQ
M
E
H
P
D
EH
Q
N
V
R
QL
IGKLHERQQ
N
V
P
VFLL
G
DR
E
KA
L
AAM
DR
---
DL
L
E
-----
L
V
D
E
F
AWI
L
ED
T
A
DF
IA
G
R
AV
A
A
M
T
R
Y
RQQ
L
LPPL
FS
AL
M
KY
S
D
I
H
E
Y
SWAA
PGH
Q
GG
VG
F
T
K
T
P
A
G
R
FYH
D
YY
G
E
N
L
F
R
T
D
M
G
I
ER
T
S
LGSLLDHTG
AF
G
E
S
E
R
Y
A
ARVFGADRS
W
S
V
VV
GTS
G
SN
RTIMQA
C
MT
D
NDV
V
VV
DRNCHKS
I
E
QG
LM
L
T
GA
K
PVY
MV
P
S
RN
R
YGI
I
G
P
I
Y
PQ
E
M
Q
PE
T
L
Q
KK
I
S
E
S
P
LTKDK
V
G
Q
K
P
SYC
V
V
TN
C
TYDG
VC
YN
AK
E
AQ
D
L
L
EK
T
S
DRL
HFD
E
AW
YG
Y
A
R
F
N
PIY
A
DH
Y
A
M
R
GE
--
PGDH
N
G
PTV
F
A
T
H
STHKLL
N
ALSQAS
Y
IHV
REG
-
R
G
AI
N
FS
R
FN
Q
AYMMH
A
TTSP
L
Y
A
I
C
AS
N
DV
A
VS
MM
D
GN
S
G
LS
L
TQ
E
V
I
DE
A
V
D
FR
QA
M
A
---
RL
Y
K
E
FTADGS
WFF
K
P
W
NK
EV
V
T
D
PQTGKTYDFADAPTKLLTTV
Q
D
CW
V
M
H
PGE
S
WHGF
--
KDI
P
D
N
WS
M
LDPIKV
S
IL
A
PGM
G
EDG
E
LE
E
T
G
V
PAALV
TA
W
L
GR
HGIV
PTR
T
TDFQIM
FLFS
M
G
VTRG
K
W
GT
L
VN
T
L
C
S
FKR
H
YD
A
N
TP
L
AQVM
P
E
L
V
E
QY
PD
T
Y
A
N
I
G
I
H
DL
GD
T
MFAWL
KE
N
N
PG
A
RL
N
E
A
Y
SG
LP
V
A
E
I
TP
RE
A
Y
N
AI
V
D
N
N
VE
L
V
S
I
E
N
L
P
GRI
A
AN
SVI
PYPPG
I
P
M
L
LS
GE
N
F
G
D
KNS
P
QV
S
Y
L
R
S
L
Q
S
W
D
H
H
F
PGFE
HETE
G
T
EI-I
DG
I
Y
H
V
M
CV
K
fig|340185.3.peg.1410
Escherichia coli E22 (22-755/756)
V
E
R
L
AD
AL
SQ
QN
VTV
I
K
S
T
S
F
DD
GFA
I
LS
S
N
E
A
I
DCLM
F
SYQ
M
E
H
P
D
EH
Q
N
V
R
QL
IGKLHERQQ
N
V
P
VFLL
G
DR
E
KA
L
AAM
DR
---
DL
L
E
-----
L
V
D
E
F
AWI
L
ED
T
A
DF
IA
G
R
AV
A
A
M
T
R
Y
RQQ
L
LPPL
FS
AL
M
KY
S
D
I
H
E
Y
SWAA
PGH
Q
GG
VG
F
T
K
T
P
A
G
R
FYH
D
YY
G
E
N
L
F
R
T
D
M
G
I
ER
T
S
LGSLLDHTG
AF
G
E
S
E
K
Y
A
ARVFGADRS
W
S
V
VV
GTS
G
SN
RTIMQA
C
MT
D
NDV
V
VV
DRNCHKS
I
E
QG
LM
L
T
GA
K
PVY
MV
P
S
RN
R
YGI
I
G
P
I
Y
PQ
E
M
Q
PE
T
L
Q
KK
I
S
E
S
P
LTKDK
A
G
Q
K
P
SYC
V
V
TN
C
TYDG
VC
YN
AK
E
AQ
D
L
L
EK
T
S
DRL
HFD
E
AW
YG
Y
A
R
I
N
PIY
A
DH
Y
A
M
R
GE
--
PGDH
N
G
PTV
F
A
T
H
STHKLL
N
ALSQAS
Y
IHV
REG
-
R
G
AI
N
FS
R
FN
Q
AYMMH
A
TTSP
L
Y
A
I
C
AS
N
DV
A
VS
MM
D
GN
S
G
LS
L
TQ
E
V
I
DE
A
V
D
FR
QA
M
A
---
RL
Y
K
E
FTADGS
WFF
K
P
W
NK
EV
V
T
D
PQTGKTYDFADAPTKLLTTV
Q
D
CW
V
M
H
PGE
S
WHGF
--
KDI
P
D
N
WS
M
LDPIKV
S
IL
A
PGM
G
EDG
E
LE
E
T
G
V
PAALV
TA
W
L
GR
HGIV
PTR
T
TDFQIM
FLFS
M
G
VTRG
K
W
GT
L
VN
T
L
C
S
FKR
H
YD
A
N
TP
L
AQVM
P
E
L
V
E
QY
PD
T
Y
A
NM
G
I
H
DL
GD
T
MFAWL
KE
N
N
PG
A
RL
N
E
A
Y
SG
LP
V
A
E
V
TP
RE
A
Y
N
AI
V
D
N
N
VE
L
V
S
I
E
N
L
P
GRI
A
AN
SVI
PYPPG
I
P
M
L
LS
GE
N
F
G
D
KNS
P
QV
S
Y
L
R
S
L
Q
S
W
D
H
H
F
PGFE
HETE
G
T
EI-I
DG
I
Y
H
V
M
CV
K
fig|340185.4.peg.1493
Escherichia coli E22 (22-755/756)
V
E
R
L
AD
AL
SQ
QN
VTV
I
K
S
T
S
F
DD
GFA
I
LS
S
N
E
A
I
DCLM
F
SYQ
M
E
H
P
D
EH
Q
N
V
R
QL
IGKLHERQQ
N
V
P
VFLL
G
DR
E
KA
L
AAM
DR
---
DL
L
E
-----
L
V
D
E
F
AWI
L
ED
T
A
DF
IA
G
R
AV
A
A
M
T
R
Y
RQQ
L
LPPL
FS
AL
M
KY
S
D
I
H
E
Y
SWAA
PGH
Q
GG
VG
F
T
K
T
P
A
G
R
FYH
D
YY
G
E
N
L
F
R
T
D
M
G
I
ER
T
S
LGSLLDHTG
AF
G
E
S
E
K
Y
A
ARVFGADRS
W
S
V
VV
GTS
G
SN
RTIMQA
C
MT
D
NDV
V
VV
DRNCHKS
I
E
QG
LM
L
T
GA
K
PVY
MV
P
S
RN
R
YGI
I
G
P
I
Y
PQ
E
M
Q
PE
T
L
Q
KK
I
S
E
S
P
LTKDK
A
G
Q
K
P
SYC
V
V
TN
C
TYDG
VC
YN
AK
E
AQ
D
L
L
EK
T
S
DRL
HFD
E
AW
YG
Y
A
R
I
N
PIY
A
DH
Y
A
M
R
GE
--
PGDH
N
G
PTV
F
A
T
H
STHKLL
N
ALSQAS
Y
IHV
REG
-
R
G
AI
N
FS
R
FN
Q
AYMMH
A
TTSP
L
Y
A
I
C
AS
N
DV
A
VS
MM
D
GN
S
G
LS
L
TQ
E
V
I
DE
A
V
D
FR
QA
M
A
---
RL
Y
K
E
FTADGS
WFF
K
P
W
NK
EV
V
T
D
PQTGKTYDFADAPTKLLTTV
Q
D
CW
V
M
H
PGE
S
WHGF
--
KDI
P
D
N
WS
M
LDPIKV
S
IL
A
PGM
G
EDG
E
LE
E
T
G
V
PAALV
TA
W
L
GR
HGIV
PTR
T
TDFQIM
FLFS
M
G
VTRG
K
W
GT
L
VN
T
L
C
S
FKR
H
YD
A
N
TP
L
AQVM
P
E
L
V
E
QY
PD
T
Y
A
NM
G
I
H
DL
GD
T
MFAWL
KE
N
N
PG
A
RL
N
E
A
Y
SG
LP
V
A
E
V
TP
RE
A
Y
N
AI
V
D
N
N
VE
L
V
S
I
E
N
L
P
GRI
A
AN
SVI
PYPPG
I
P
M
L
LS
GE
N
F
G
D
KNS
P
QV
S
Y
L
R
S
L
Q
S
W
D
H
H
F
PGFE
HETE
G
T
EI-I
DG
I
Y
H
V
M
CV
K
fig|155864.8.peg.5041
Escherichia coli O157:H7 EDL933 (22-755/756)
V
E
R
L
AD
AL
SQ
QN
VTV
I
K
S
T
S
F
DD
GFA
I
LS
S
N
E
A
I
DCLM
F
SYQ
M
E
H
P
D
EH
Q
N
V
R
QL
IGKLHERQQ
N
V
P
VFLL
G
DR
E
KA
L
AAM
DR
---
DL
L
E
-----
L
V
D
E
F
AWI
L
ED
T
A
DF
IA
G
R
AV
A
A
M
T
R
Y
RQQ
L
LPPL
FS
AL
M
KY
S
D
I
H
E
Y
SWAA
PGH
Q
GG
VG
F
T
K
T
P
A
G
R
FYH
D
YY
G
E
N
L
F
R
T
D
M
G
I
ER
T
S
LGSLLDHTG
AF
G
E
S
E
K
Y
A
ARVFGADRS
W
S
V
VV
X
TS
G
SN
RTIMQA
C
MT
D
NDV
V
VV
DRNCHKS
I
E
QG
LM
L
T
GA
K
PVY
MV
P
S
RN
R
YGI
I
G
P
I
Y
PQ
E
M
Q
PE
T
L
Q
KK
I
S
E
S
P
LTKDK
A
G
Q
K
P
SYC
V
V
TN
C
TYDG
VC
YN
AK
E
AQ
D
L
L
EK
T
S
DRL
HFD
E
AW
YG
Y
A
R
F
N
PIY
A
DH
Y
A
M
R
GE
--
PGDH
N
G
PTV
F
A
T
H
STHKLL
N
ALSQAS
Y
IHV
REG
-
R
G
AI
N
FS
R
FN
Q
AYMMH
A
TTSP
L
Y
A
I
C
AS
N
DV
A
VS
MM
D
GN
S
G
LS
L
TQ
E
V
I
DE
A
V
D
FR
QA
M
A
---
RL
Y
K
E
F
A
ADGS
WFF
K
P
W
NK
EV
V
T
D
PQTGKTYDFADAPTKLLTTV
Q
D
CW
V
M
H
PGE
S
WHGF
--
KDI
P
D
N
WS
M
LDPIKV
S
IL
A
PGM
G
EDG
E
LE
E
T
G
V
PAALV
TA
W
L
GR
HGIV
PTR
T
TDFQIM
FLFS
M
G
VTRG
K
W
GT
L
VN
T
L
C
S
FKR
H
YD
A
N
TP
L
AQVM
P
E
L
V
E
QY
PD
T
Y
A
NM
G
I
H
DL
GD
T
MFAWL
KE
N
N
PG
A
RL
N
E
A
Y
SG
LP
V
A
E
I
TP
RE
A
Y
N
AI
V
D
N
N
VE
L
V
S
I
E
N
L
P
GRI
A
AN
SVI
PYPPG
I
P
M
L
LS
GE
N
F
G
D
KNS
P
QV
S
Y
L
R
S
L
Q
S
W
D
H
H
F
PGFE
HETE
G
T
EI-I
DG
I
Y
H
V
M
CV
K
Consen1
Primary consensus
MNvIAIlnhmGVyfKeEPireL
AL
qnfqii
p
d
dDllk
ienN
ricgviFdwd
ynldlc
ei
ql
-------
nenlPlyaf
nt
stldvs
---
Dlr
-----
i
fFeyaLg
-
AedIA
r
q
t
eY
ilPPltkALfkYv
e
kYtfctPGHmGGtafqKsPvG
lfyDffG
Nt
ksDisIsvteLGSLLDHtGph
EaEqYiARvFgAdrSy
VtnGTStsNkivgmy
ap
gstiliDRNCHKSl
hllMmsdv
Pvy
PtRNayGIlGgIp
Efq
ti
kkv
etp
-----
aqwPvhaViTNsTYDGllYNtd
ikktLdv
S
--
iHFDsAWvpYt
FsPIY
gk
gMsGerv
----
GkvifeTqSTHKlLaAlSQAS
IHv
----
kG
nee
FNeAyMMHtTTSP
Y
IvAS
etAaaMm
GN
GkrLin
sierAi
FRkei
---
RLr
E
---
sdgWFFd
Wqp
vd
--------------------
eCWpl
pge
WHGF
--
kdid
ehm
LDPiKVtiLtPGM
edG
mse
GiPAalVakyLdehGIVvekTgpynllFLFSiGidktKa
Llr
Lt
FKR
yDlNlrvknmlP
Ly
edPdfY
NMrIqdLaq
ihkli
hnlp
lm
rAf
LP
m
mTP
Afq
l
g
vE
v
le
lvGRinANmilPYPPGvPllmpGEm
teesrpvl
fL
mLcs
g
HyPGFEtdihGa
DG
Y
V
vlKMAG
Consen2
Secondary consensus
i
mgph
fy
d
v
r
lgvtvv
s
v
gfa
ls
aldclm
syq
e
peeh
v
kmigklherqqyv
vfll
dr
kamaam
ml
e
awi
ed
df
k
a
m
r
lt
ffs
mt
s
i
e
swaa
q
vgyt
t
a
fyh
yy
l
r
g
erss
s
af
s
a
t
n
eq
w
vv
ga
rtimqa
mt
ndv
vv
i
qgm
l
ga
iw
s
rl
i
p
y
mt
sl
eri
astltkdk
gtk
syc
v
c
vc
ak
aq
l
ek
drl
e
yg
a
dh
a
r
g
--
pgdh
ptvya
h
m
n
f
ireg
r
dfs
q
f
a
c
dv
vs
l
ls
tq
vvde
qa
y
ftadgs
k
nk
it
pqtgktydfadaptkllttv
d
v
sds
nnap
ws
v
sl
a
kq
led
v
si
ta
grr
ptr
tdfqim
m
vtrg
w
vn
c
f
a
tp
aqvm
v
qy
et
g
he
gd
mfawl
ndpg
rl
e
y
a
i
n
n
t
i
id
mp
v
svi
i
mvls
n
g
knstqv
y
s
qe
d
f
hete
t
cv
Consensus 1
(when a gap)
Conservative difference
Consensus 2
(when a gap)
Nonconservative diff.
Other character