fig|358709.5.peg.3852
Escherichia coli 101-1
MAR
SKT
A
QPK
HSL
RKIAVV
V
A
T
AVS
G
MSVY
AQA
-
A
V
E
PK-
--
EDT
I
T
V
T
A
A
P
---
-
APQ
E
SA
WGPA
ATIAARQSAT
GTK
TDT
P
IQ
K
V
PQS
I
S
VV
T
A
E
E
M
A
LH
Q
PK
S
V
K
EAL
S
Y
TPGV
S
---
V
G
TR
G
A
S
N
T
Y
D
H
L
I
I
-
RGF
-
AAEG
Q
SQ
N
N
Y
L
N
G
L
KL
-------
Q
G
N
FYND
A
VI
D
PYML
ER
A
E
I
M
RGP
V
S
VL
YG
K
S
S
P
G
G
L
L
NMVSK
R
PT
T
EPL
K
-
E
V
QF
KA
G
T
DSLF
Q
TGF
D
FSDA
L
D
DDG
VY
S
Y
R
L
T
G
LA
RS
A
N
A
QQ
K
GSEE
Q
RY
AI
AP
A--
F
T
WR
PDDK
T
NFT
----------
F
L
SYF
Q
N
E--
-
---
P
E
T
G
YY
G
W-
LP
KE
GT
VEPL
--
P
N
GK
-
-
-----RL
P
T
D
F
N
E
GAK
N
NTY
S
R
NEKMVGYS
F
D
H
E
FNDT
F
T
V
R
Q
N
L
R
F
A
E
N
K
T
S
Q
--
NS
V
YG
-
-
Y
GVCS
D
PANAY
S
KQ
--------
CAALAPADKGHYLA
R
KYVVD
D
EKL
Q
N
F
SV
D
T
Q
L
Q
S
K
F
A
TG
D
I
D
H
T
L
L
---------------
TGV
D
F
M
R
MR
N
DIN
A
W
--------------------
F
G
YD
DSV
P
LLN
-
LY
N
PVN
T
D
-
FDFNAKDPA
N
SG
P
YRIL----
N
KQK
QT
---G
V
Y
V
Q
D
QA
Q
WDKV
L
V
T
L
GG
-
-
--
-
-
--
RYD
W
A
D
Q
------------
ESLNRVAGT
T
D
-----
KRDD
K
QF
TW
R
G
G
VN
Y
-
L
F
DNG
V
T
P
Y
F
SY
S
E
SF
E
-----
P
---------
S
S
-QV
---
G
K
D
G
NI
-
FAP
S
KG
K
Q
YE
V
G
V
K
YVPE
D
R
PI
VV
T
G
A
V
YN
LTKT
N
NLM
--------
A
D
P
EG
S
F
FS
V
EG
G
EI
R
A
R
GVEIE
AK
---
A
A
LS
A
S
VN
V
V
G
S
YT
YTD
AE
YTTD
T
TY
K
GN
TP
AQ
--------
V
P
K
H
MAS
LW
A
D
Y
TFF
D
G
P
LS
G
LT
L
G
T
G
G
RY
T
G
--
S
S
Y---G
D
-
P
A
-
-
N
-S
F
KV
GSY
T
VVDA
LV
RY
D
L
A
R
VGMAG
S
N
V
A
L
H
VNNLFD
RE
YVAS
CFN
T
-
Y
-------
GCFW
GA
E
R
Q
V
VA
TAT
FR
F
fig|670888.3.peg.735
Escherichia coli 1827-70
MAR
SKT
A
QPK
HSL
RKIAVV
V
A
T
AVS
G
MSVY
AQA
-
A
V
E
PK-
--
EDT
I
T
V
T
A
A
P
---
-
APQ
E
SA
WGPA
ATIAARQSAT
GTK
TDT
P
IQ
K
V
PQS
I
S
VV
T
A
E
E
M
A
LH
Q
PK
S
V
K
EAL
S
Y
TPGV
S
---
V
G
TR
G
A
S
N
T
Y
D
H
L
I
I
-
RGF
-
AAEG
Q
SQ
N
N
Y
L
N
G
L
KL
-------
Q
G
N
FYND
A
VI
D
PYML
ER
A
E
I
M
RGP
V
S
VL
YG
K
S
S
P
G
G
L
L
NMVSK
R
PT
T
EPL
K
-
E
V
QF
KA
G
T
DSLF
Q
TGF
D
FSDA
L
D
DDG
VY
S
Y
R
L
T
G
LA
RS
A
N
A
QQ
K
GSEE
Q
RY
AI
AP
A--
F
T
WR
PDDK
T
NFT
----------
F
L
SYF
Q
N
E--
-
---
P
E
T
G
YY
G
W-
LP
KE
GT
VEPL
--
P
N
GK
-
-
-----RL
P
T
D
F
N
E
GAK
N
NTY
S
R
NEKMVGYS
F
D
H
E
FNDT
F
T
V
R
Q
N
L
R
F
A
E
N
K
T
S
Q
--
NS
V
YG
-
-
Y
GVCS
D
PANAY
S
KQ
--------
CAALAPADKGHYLA
R
KYVVD
D
EKL
Q
N
F
SV
D
T
Q
L
Q
S
K
F
A
TG
D
I
D
H
T
L
L
---------------
TGV
D
F
M
R
MR
N
DIN
A
W
--------------------
F
G
YD
DSV
P
LLN
-
LY
N
PVN
T
D
-
FDFNAKDPA
N
SG
P
YRIL----
N
KQK
QT
---G
V
Y
V
Q
D
QA
Q
WDKV
L
V
T
L
GG
-
-
--
-
-
--
RYD
W
A
D
Q
------------
ESLNRVAGT
T
D
-----
KRDD
K
QF
TW
R
G
G
VN
Y
-
L
F
DNG
V
T
P
Y
F
SY
S
E
SF
E
-----
P
---------
S
S
-QV
---
G
K
D
G
NI
-
FAP
S
KG
K
Q
YE
V
G
V
K
YVPE
D
R
PI
VV
T
G
A
V
YN
LTKT
N
NLM
--------
A
D
P
EG
S
F
FS
V
EG
G
EI
R
A
R
GVEIE
AK
---
A
A
LS
A
S
VN
V
V
G
S
YT
YTD
AE
YTTD
T
TY
K
GN
TP
AQ
--------
V
P
K
H
MAS
LW
A
D
Y
TFF
D
G
P
LS
G
LT
L
G
T
G
G
RY
T
G
--
S
S
Y---G
D
-
P
A
-
-
N
-S
F
KV
GSY
T
VVDA
LV
RY
D
L
A
R
VGMAG
S
N
V
A
L
H
VNNLFD
RE
YVAS
CFN
T
-
Y
-------
GCFW
GA
E
R
Q
V
VA
TAT
FR
F
fig|344610.3.peg.4055
Escherichia coli 53638
MAR
SKT
A
QPK
HSL
RKIAVV
V
A
T
AVS
G
MSVY
AQA
-
A
V
E
PK-
--
EDT
I
T
V
T
A
A
P
---
-
APQ
E
SA
WGPA
ATIAARQSAT
GTK
TDT
P
IQ
K
V
PQS
I
S
VV
T
A
E
E
M
A
LH
Q
PK
S
V
K
EAL
S
Y
TPGV
S
---
V
G
TR
G
A
S
N
T
Y
D
H
L
I
I
-
RGF
-
AAEG
Q
SQ
N
N
Y
L
N
G
L
KL
-------
Q
G
N
FYND
A
VI
D
PYML
ER
A
E
I
M
RGP
V
S
VL
YG
K
S
S
P
G
G
L
L
NMVSK
R
PT
T
EPL
K
-
E
V
QF
KA
G
T
DSLF
Q
TGF
D
FSDA
L
D
DDG
VY
S
Y
R
L
T
G
LA
RS
A
N
A
QQ
K
GSEE
Q
RY
AI
AP
A--
F
T
WR
PDDK
T
NFT
----------
F
L
SYF
Q
N
E--
-
---
P
E
T
G
YY
G
W-
LP
KE
GT
VEPL
--
P
N
GK
-
-
-----RL
P
T
D
F
N
E
GAK
N
NTY
S
R
NEKMVGYS
F
D
H
E
FNDT
F
T
V
R
Q
N
L
R
F
A
E
N
K
T
S
Q
--
NS
V
YG
-
-
Y
GVCS
D
PANAY
S
KQ
--------
CAALAPADKGHYLA
R
KYVVD
D
EKL
Q
N
F
SV
D
T
Q
L
Q
S
K
F
A
TG
D
I
D
H
T
L
L
---------------
TGV
D
F
M
R
MR
N
DIN
A
W
--------------------
F
G
YD
DSV
P
LLN
-
LY
N
PVN
T
D
-
FDFNAKDPA
N
SG
P
YRIL----
N
KQK
QT
---G
V
Y
V
Q
D
QA
Q
WDKV
L
V
T
L
GG
-
-
--
-
-
--
RYD
W
A
D
Q
------------
ESLNRVAGT
T
D
-----
KRDD
K
QF
TW
R
G
G
VN
Y
-
L
F
DNG
V
T
P
Y
F
SY
S
E
SF
E
-----
P
---------
S
S
-QV
---
G
K
D
G
NI
-
FAP
S
KG
K
Q
YE
V
G
V
K
YVPE
D
R
PI
VV
T
G
A
V
YN
LTKT
N
NLM
--------
A
D
P
EG
S
F
FS
V
EG
G
EI
R
A
R
GVEIE
AK
---
A
A
LS
A
S
VN
V
V
G
S
YT
YTD
AE
YTTD
T
TY
K
GN
TP
AQ
--------
V
P
K
H
MAS
LW
A
D
Y
TFF
D
G
P
LS
G
LT
L
G
T
G
G
RY
T
G
--
S
S
Y---G
D
-
P
A
-
-
N
-S
F
KV
GSY
T
VVDA
LV
RY
D
L
A
R
VGMAG
S
N
V
A
L
H
VNNLFD
RE
YVAS
CFN
T
-
Y
-------
GCFW
GA
E
R
Q
V
VA
TAT
FR
F
fig|481805.3.peg.3772
Escherichia coli ATCC 8739
MAR
SKT
A
QPK
HSL
RKIAVV
V
A
T
AVS
G
MSVY
AQA
-
A
V
E
PK-
--
EDT
I
T
V
T
A
A
P
---
-
APQ
E
SA
WGPA
ATIAARQSAT
GTK
TDT
P
IQ
K
V
PQS
I
S
VV
T
A
E
E
M
A
LH
Q
PK
S
V
K
EAL
S
Y
TPGV
S
---
V
G
TR
G
A
S
N
T
Y
D
H
L
I
I
-
RGF
-
AAEG
Q
SQ
N
N
Y
L
N
G
L
KL
-------
Q
G
N
FYND
A
VI
D
PYML
ER
A
E
I
M
RGP
V
S
VL
YG
K
S
S
P
G
G
L
L
NMVSK
R
PT
T
EPL
K
-
E
V
QF
KA
G
T
DSLF
Q
TGF
D
FSDA
L
D
DDG
VY
S
Y
R
L
T
G
LA
RS
A
N
A
QQ
K
GSEE
Q
RY
AI
AP
A--
F
T
WR
PDDK
T
NFT
----------
F
L
SYF
Q
N
E--
-
---
P
E
T
G
YY
G
W-
LP
KE
GT
VEPL
--
P
N
GK
-
-
-----RL
P
T
D
F
N
E
GAK
N
NTY
S
R
NEKMVGYS
F
D
H
E
FNDT
F
T
V
R
Q
N
L
R
F
A
E
N
K
T
S
Q
--
NS
V
YG
-
-
Y
GVCS
D
PANAY
S
KQ
--------
CAALAPADKGHYLA
R
KYVVD
D
EKL
Q
N
F
SV
D
T
Q
L
Q
S
K
F
A
TG
D
I
D
H
T
L
L
---------------
TGV
D
F
M
R
MR
N
DIN
A
W
--------------------
F
G
YD
DSV
P
LLN
-
LY
N
PVN
T
D
-
FDFNAKDPA
N
SG
P
YRIL----
N
KQK
QT
---G
V
Y
V
Q
D
QA
Q
WDKV
L
V
T
L
GG
-
-
--
-
-
--
RYD
W
A
D
Q
------------
ESLNRVAGT
T
D
-----
KRDD
K
QF
TW
R
G
G
VN
Y
-
L
F
DNG
V
T
P
Y
F
SY
S
E
SF
E
-----
P
---------
S
S
-QV
---
G
K
D
G
NI
-
FAP
S
KG
K
Q
YE
V
G
V
K
YVPE
D
R
PI
VV
T
G
A
V
YN
LTKT
N
NLM
--------
A
D
P
EG
S
F
FS
V
EG
G
EI
R
A
R
GVEIE
AK
---
A
A
LS
A
S
VN
V
V
G
S
YT
YTD
AE
YTTD
T
TY
K
GN
TP
AQ
--------
V
P
K
H
MAS
LW
A
D
Y
TFF
D
G
P
LS
G
LT
L
G
T
G
G
RY
T
G
--
S
S
Y---G
D
-
P
A
-
-
N
-S
F
KV
GSY
T
VVDA
LV
RY
D
L
A
R
VGMAG
S
N
V
A
L
H
VNNLFD
RE
YVAS
CFN
T
-
Y
-------
GCFW
GA
E
R
Q
V
VA
TAT
FR
F
fig|481805.6.peg.3749
Escherichia coli ATCC 8739
MAR
SKT
A
QPK
HSL
RKIAVV
V
A
T
AVS
G
MSVY
AQA
-
A
V
E
PK-
--
EDT
I
T
V
T
A
A
P
---
-
APQ
E
SA
WGPA
ATIAARQSAT
GTK
TDT
P
IQ
K
V
PQS
I
S
VV
T
A
E
E
M
A
LH
Q
PK
S
V
K
EAL
S
Y
TPGV
S
---
V
G
TR
G
A
S
N
T
Y
D
H
L
I
I
-
RGF
-
AAEG
Q
SQ
N
N
Y
L
N
G
L
KL
-------
Q
G
N
FYND
A
VI
D
PYML
ER
A
E
I
M
RGP
V
S
VL
YG
K
S
S
P
G
G
L
L
NMVSK
R
PT
T
EPL
K
-
E
V
QF
KA
G
T
DSLF
Q
TGF
D
FSDA
L
D
DDG
VY
S
Y
R
L
T
G
LA
RS
A
N
A
QQ
K
GSEE
Q
RY
AI
AP
A--
F
T
WR
PDDK
T
NFT
----------
F
L
SYF
Q
N
E--
-
---
P
E
T
G
YY
G
W-
LP
KE
GT
VEPL
--
P
N
GK
-
-
-----RL
P
T
D
F
N
E
GAK
N
NTY
S
R
NEKMVGYS
F
D
H
E
FNDT
F
T
V
R
Q
N
L
R
F
A
E
N
K
T
S
Q
--
NS
V
YG
-
-
Y
GVCS
D
PANAY
S
KQ
--------
CAALAPADKGHYLA
R
KYVVD
D
EKL
Q
N
F
SV
D
T
Q
L
Q
S
K
F
A
TG
D
I
D
H
T
L
L
---------------
TGV
D
F
M
R
MR
N
DIN
A
W
--------------------
F
G
YD
DSV
P
LLN
-
LY
N
PVN
T
D
-
FDFNAKDPA
N
SG
P
YRIL----
N
KQK
QT
---G
V
Y
V
Q
D
QA
Q
WDKV
L
V
T
L
GG
-
-
--
-
-
--
RYD
W
A
D
Q
------------
ESLNRVAGT
T
D
-----
KRDD
K
QF
TW
R
G
G
VN
Y
-
L
F
DNG
V
T
P
Y
F
SY
S
E
SF
E
-----
P
---------
S
S
-QV
---
G
K
D
G
NI
-
FAP
S
KG
K
Q
YE
V
G
V
K
YVPE
D
R
PI
VV
T
G
A
V
YN
LTKT
N
NLM
--------
A
D
P
EG
S
F
FS
V
EG
G
EI
R
A
R
GVEIE
AK
---
A
A
LS
A
S
VN
V
V
G
S
YT
YTD
AE
YTTD
T
TY
K
GN
TP
AQ
--------
V
P
K
H
MAS
LW
A
D
Y
TFF
D
G
P
LS
G
LT
L
G
T
G
G
RY
T
G
--
S
S
Y---G
D
-
P
A
-
-
N
-S
F
KV
GSY
T
VVDA
LV
RY
D
L
A
R
VGMAG
S
N
V
A
L
H
VNNLFD
RE
YVAS
CFN
T
-
Y
-------
GCFW
GA
E
R
Q
V
VA
TAT
FR
F
fig|749547.3.peg.4145
Escherichia coli MS 187-1
MAR
SKT
A
QPK
HSL
RKIAVV
V
A
T
AVS
G
MSVY
AQA
-
A
V
E
PK-
--
EDT
I
T
V
T
A
A
P
---
-
APQ
E
SA
WGPA
ATIAARQSAT
GTK
TDT
P
IQ
K
V
PQS
I
S
VV
T
A
E
E
M
A
LH
Q
PK
S
V
K
EAL
S
Y
TPGV
S
---
V
G
TR
G
A
S
N
T
Y
D
H
L
I
I
-
RGF
-
AAEG
Q
SQ
N
N
Y
L
N
G
L
KL
-------
Q
G
N
FYND
A
VI
D
PYML
ER
A
E
I
M
RGP
V
S
VL
YG
K
S
S
P
G
G
L
L
NMVSK
R
PT
T
EPL
K
-
E
V
QF
KA
G
T
DSLF
Q
TGF
D
FSDA
L
D
DDG
VY
S
Y
R
L
T
G
LA
RS
A
N
A
QQ
K
GSEE
Q
RY
AI
AP
A--
F
T
WR
PDDK
T
NFT
----------
F
L
SYF
Q
N
E--
-
---
P
E
T
G
YY
G
W-
LP
KE
GT
VEPL
--
P
N
GK
-
-
-----RL
P
T
D
F
N
E
GAK
N
NTY
S
R
NEKMVGYS
F
D
H
E
FNDT
F
T
V
R
Q
N
L
R
F
A
E
N
K
T
S
Q
--
NS
V
YG
-
-
Y
GVCS
D
PANAY
S
KQ
--------
CAALAPADKGHYLA
R
KYVVD
D
EKL
Q
N
F
SV
D
T
Q
L
Q
S
K
F
A
TG
D
I
D
H
T
L
L
---------------
TGV
D
F
M
R
MR
N
DIN
A
W
--------------------
F
G
YD
DSV
P
LLN
-
LY
N
PVN
T
D
-
FDFNAKDPA
N
SG
P
YRIL----
N
KQK
QT
---G
V
Y
V
Q
D
QA
Q
WDKV
L
V
T
L
GG
-
-
--
-
-
--
RYD
W
A
D
Q
------------
ESLNRVAGT
T
D
-----
KRDD
K
QF
TW
R
G
G
VN
Y
-
L
F
DNG
V
T
P
Y
F
SY
S
E
SF
E
-----
P
---------
S
S
-QV
---
G
K
D
G
NI
-
FAP
S
KG
K
Q
YE
V
G
V
K
YVPE
D
R
PI
VV
T
G
A
V
YN
LTKT
N
NLM
--------
A
D
P
EG
S
F
FS
V
EG
G
EI
R
A
R
GVEIE
AK
---
A
A
LS
A
S
VN
V
V
G
S
YT
YTD
AE
YTTD
T
TY
K
GN
TP
AQ
--------
V
P
K
H
MAS
LW
A
D
Y
TFF
D
G
P
LS
G
LT
L
G
T
G
G
RY
T
G
--
S
S
Y---G
D
-
P
A
-
-
N
-S
F
KV
GSY
T
VVDA
LV
RY
D
L
A
R
VGMAG
S
N
V
A
L
H
VNNLFD
RE
YVAS
CFN
T
-
Y
-------
GCFW
GA
E
R
Q
V
VA
TAT
FR
F
fig|413997.3.peg.159
Escherichia coli B str. REL606
MAR
SKT
A
QPK
HSL
RKIAVV
V
A
T
AVS
G
MSVY
AQA
-
A
V
E
PK-
--
EDT
I
T
V
T
A
A
P
---
-
APQ
E
SA
WGPA
ATIAARQSAT
GTK
TDT
P
IQ
K
V
PQS
I
S
VV
T
A
E
E
M
A
LH
Q
PK
S
V
K
EAL
S
Y
TPGV
S
---
V
G
TR
G
A
S
N
T
Y
D
H
L
I
I
-
RGF
-
AAEG
Q
SQ
N
N
Y
L
N
G
L
KL
-------
Q
G
N
FYND
A
AI
D
PYML
ER
A
E
I
M
RGP
V
S
VL
YG
K
S
S
P
G
G
L
L
NMVSK
R
PT
T
EPL
K
-
E
V
QF
KA
G
T
DSLF
Q
TGF
D
FSDA
L
D
DDG
VY
S
Y
R
L
T
G
LA
RS
A
N
A
QQ
K
GSEE
Q
RY
AI
AP
A--
F
T
WR
PDDK
T
NFT
----------
F
L
SYF
Q
N
E--
-
---
P
E
T
G
YY
G
W-
LP
KE
GT
VEPL
--
P
N
GK
-
-
-----RL
P
T
D
F
N
E
GAK
N
NTY
S
R
NEKMVGYS
F
D
H
E
FNDT
F
T
V
R
Q
N
L
R
F
A
E
N
K
T
S
Q
--
NS
V
YG
-
-
Y
GVCS
D
PANAY
S
KQ
--------
CAALAPADKGHYLA
R
KYVVD
D
EKL
Q
N
F
SV
D
T
Q
L
Q
S
K
F
A
TG
D
I
D
H
T
L
L
---------------
TGV
D
F
M
R
MR
N
DIN
A
W
--------------------
F
G
YD
DSV
P
LLN
-
LY
N
PVN
T
D
-
FDFNAKDPA
N
SG
P
YRIL----
N
KQK
QT
---G
V
Y
V
Q
D
QA
Q
WDKV
L
V
T
L
GG
-
-
--
-
-
--
RYD
W
A
D
Q
------------
ESLNRVAGT
T
D
-----
KRDD
K
QF
TW
R
G
G
VN
Y
-
L
F
DNG
V
T
P
Y
F
SY
S
E
SF
E
-----
P
---------
S
S
-QV
---
G
K
D
G
NI
-
FAP
S
KG
K
Q
YE
V
G
V
K
YVPE
D
R
PI
VV
T
G
A
V
YN
LTKT
N
NLM
--------
A
D
P
EG
S
F
FS
V
EG
G
EI
R
A
R
GVEIE
AK
---
A
A
LS
A
S
VN
V
V
G
S
YT
YTD
AE
YTTD
T
TY
K
GN
TP
AQ
--------
V
P
K
H
MAS
LW
A
D
Y
TFF
D
G
P
LS
G
LT
L
G
T
G
G
RY
T
G
--
S
S
Y---G
D
-
P
A
-
-
N
-S
F
KV
GSY
T
VVDA
LV
RY
D
L
A
R
VGMAG
S
N
V
A
L
H
VNNLFD
RE
YVAS
CFN
T
-
Y
-------
GCFW
GA
E
R
Q
V
VA
TAT
FR
F
fig|562.373.peg.2109
Escherichia coli 1125A
MAR
SKT
A
QPK
HSL
RKIAVV
V
A
T
AVS
G
MSVY
AQA
-
A
V
E
PK-
--
EDT
I
T
V
T
A
A
P
---
-
APQ
E
SA
WGPA
ATIAARQSAT
GTK
TDT
P
IQ
K
V
PQS
I
S
VV
T
A
E
E
M
A
LH
Q
PK
S
V
K
EAL
S
Y
TPGV
S
---
V
G
TR
G
A
S
N
T
Y
D
H
L
I
I
-
RGF
-
AAEG
Q
SQ
N
N
Y
L
N
G
L
KL
-------
Q
G
N
FYND
A
VI
D
PYML
ER
A
E
I
M
RGP
V
S
VL
YG
K
S
S
P
G
G
L
L
NMVSK
R
PT
T
EPL
K
-
E
V
QF
KA
G
T
DSLF
Q
TGF
D
FSDA
L
D
DDG
VY
S
Y
R
L
T
G
LA
RS
A
N
A
QQ
K
GSEE
Q
RY
AI
AP
A--
F
T
WR
PDDK
T
NFT
----------
F
L
SYF
Q
N
E--
-
---
P
E
T
G
YY
G
W-
LP
KE
GT
VEPL
--
P
N
GK
-
-
-----RL
P
T
D
F
N
E
GAK
N
NTY
S
R
NEKMVGYS
F
D
H
E
FNDT
F
T
V
R
Q
N
L
R
F
A
E
N
K
T
S
Q
--
NS
V
YG
-
-
Y
GVCS
D
PANAY
S
KQ
--------
CAALAPADKGHYLA
R
KYVVD
D
EKL
Q
N
F
SV
D
T
Q
L
Q
S
K
F
A
TG
D
I
D
H
T
L
L
---------------
TGV
D
F
M
R
MR
N
DIN
A
W
--------------------
F
G
YD
DSV
P
LLD
-
LY
N
PVN
T
D
-
FDFNAKDPA
N
SG
P
YRIL----
N
KQK
QT
---G
V
Y
V
Q
D
QA
Q
WDKV
L
V
T
L
GG
-
-
--
-
-
--
RYD
W
A
D
Q
------------
ESLNRVAGT
T
D
-----
KRDD
K
QF
TW
R
G
G
VN
Y
-
L
F
DNG
V
T
P
Y
F
SY
S
E
SF
E
-----
P
---------
S
S
-QV
---
G
K
D
G
NI
-
FAP
S
KG
K
Q
YE
V
G
V
K
YVPE
D
R
PI
VV
T
G
A
V
YN
LTKT
N
NLM
--------
A
D
P
EG
S
F
FS
V
EG
G
EI
R
A
R
GVEIE
AK
---
A
A
LS
A
S
VN
V
V
G
S
YT
YTD
AE
YTTD
T
TY
K
GN
TP
AQ
--------
V
P
K
H
MAS
LW
A
D
Y
TFF
D
G
P
LS
G
LT
L
G
T
G
G
RY
T
G
--
S
S
Y---G
D
-
P
A
-
-
N
-S
F
KV
GSY
T
VVDA
LV
RY
D
L
A
R
VGMAG
S
N
V
A
L
H
VNNLFD
RE
YVAS
CFN
T
-
Y
-------
GCFW
GA
E
R
Q
V
VA
TAT
FR
F
fig|562.372.peg.2959
Escherichia coli 1212A
MAR
SKT
A
QPK
HSL
RKIAVV
V
A
T
AVS
G
MSVY
AQA
-
A
V
E
PK-
--
EDT
I
T
V
T
A
A
P
---
-
APQ
E
SA
WGPA
ATIAARQSAT
GTK
TDT
P
IQ
K
V
PQS
I
S
VV
T
A
E
E
M
A
LH
Q
PK
S
V
K
EAL
S
Y
TPGV
S
---
V
G
TR
G
A
S
N
T
Y
D
H
L
I
I
-
RGF
-
AAEG
Q
SQ
N
N
Y
L
N
G
L
KL
-------
Q
G
N
FYND
A
VI
D
PYML
ER
A
E
I
M
RGP
V
S
VL
YG
K
S
S
P
G
G
L
L
NMVSK
R
PT
T
EPL
K
-
E
V
QF
KA
G
T
DSLF
Q
TGF
D
FSDA
L
D
DDG
VY
S
Y
R
L
T
G
LA
RS
A
N
A
QQ
K
GSEE
Q
RY
AI
AP
A--
F
T
WR
PDDK
T
NFT
----------
F
L
SYF
Q
N
E--
-
---
P
E
T
G
YY
G
W-
LP
KE
GT
VEPL
--
P
N
GK
-
-
-----RL
P
T
D
F
N
E
GAK
N
NTY
S
R
NEKMVGYS
F
D
H
E
FNDT
F
T
V
R
Q
N
L
R
F
A
E
N
K
T
S
Q
--
NS
V
YG
-
-
Y
GVCS
D
PANAY
S
KQ
--------
CAALAPADKGHYLA
R
KYVVD
D
EKL
Q
N
F
SV
D
T
Q
L
Q
S
K
F
A
TG
D
I
D
H
T
L
L
---------------
TGV
D
F
M
R
MR
N
DIN
A
W
--------------------
F
G
YD
DSV
P
LLD
-
LY
N
PVN
T
D
-
FDFNAKDPA
N
SG
P
YRIL----
N
KQK
QT
---G
V
Y
V
Q
D
QA
Q
WDKV
L
V
T
L
GG
-
-
--
-
-
--
RYD
W
A
D
Q
------------
ESLNRVAGT
T
D
-----
KRDD
K
QF
TW
R
G
G
VN
Y
-
L
F
DNG
V
T
P
Y
F
SY
S
E
SF
E
-----
P
---------
S
S
-QV
---
G
K
D
G
NI
-
FAP
S
KG
K
Q
YE
V
G
V
K
YVPE
D
R
PI
VV
T
G
A
V
YN
LTKT
N
NLM
--------
A
D
P
EG
S
F
FS
V
EG
G
EI
R
A
R
GVEIE
AK
---
A
A
LS
A
S
VN
V
V
G
S
YT
YTD
AE
YTTD
T
TY
K
GN
TP
AQ
--------
V
P
K
H
MAS
LW
A
D
Y
TFF
D
G
P
LS
G
LT
L
G
T
G
G
RY
T
G
--
S
S
Y---G
D
-
P
A
-
-
N
-S
F
KV
GSY
T
VVDA
LV
RY
D
L
A
R
VGMAG
S
N
V
A
L
H
VNNLFD
RE
YVAS
CFN
T
-
Y
-------
GCFW
GA
E
R
Q
V
VA
TAT
FR
F
fig|562.374.peg.2150
Escherichia coli 536A
MAR
SKT
A
QPK
HSL
RKIAVV
V
A
T
AVS
G
MSVY
AQA
-
A
V
E
PK-
--
EDT
I
T
V
T
A
A
P
---
-
APQ
E
SA
WGPA
ATIAARQSAT
GTK
TDT
P
IQ
K
V
PQS
I
S
VV
T
A
E
E
M
A
LH
Q
PK
S
V
K
EAL
S
Y
TPGV
S
---
V
G
TR
G
A
S
N
T
Y
D
H
L
I
I
-
RGF
-
AAEG
Q
SQ
N
N
Y
L
N
G
L
KL
-------
Q
G
N
FYND
A
VI
D
PYML
ER
A
E
I
M
RGP
V
S
VL
YG
K
S
S
P
G
G
L
L
NMVSK
R
PT
T
EPL
K
-
E
V
QF
KA
G
T
DSLF
Q
TGF
D
FSDA
L
D
DDG
VY
S
Y
R
L
T
G
LA
RS
A
N
A
QQ
K
GSEE
Q
RY
AI
AP
A--
F
T
WR
PDDK
T
NFT
----------
F
L
SYF
Q
N
E--
-
---
P
E
T
G
YY
G
W-
LP
KE
GT
VEPL
--
P
N
GK
-
-
-----RL
P
T
D
F
N
E
GAK
N
NTY
S
R
NEKMVGYS
F
D
H
E
FNDT
F
T
V
R
Q
N
L
R
F
A
E
N
K
T
S
Q
--
NS
V
YG
-
-
Y
GVCS
D
PANAY
S
KQ
--------
CAALAPADKGHYLA
R
KYVVD
D
EKL
Q
N
F
SV
D
T
Q
L
Q
S
K
F
A
TG
D
I
D
H
T
L
L
---------------
TGV
D
F
M
R
MR
N
DIN
A
W
--------------------
F
G
YD
DSV
P
LLD
-
LY
N
PVN
T
D
-
FDFNAKDPA
N
SG
P
YRIL----
N
KQK
QT
---G
V
Y
V
Q
D
QA
Q
WDKV
L
V
T
L
GG
-
-
--
-
-
--
RYD
W
A
D
Q
------------
ESLNRVAGT
T
D
-----
KRDD
K
QF
TW
R
G
G
VN
Y
-
L
F
DNG
V
T
P
Y
F
SY
S
E
SF
E
-----
P
---------
S
S
-QV
---
G
K
D
G
NI
-
FAP
S
KG
K
Q
YE
V
G
V
K
YVPE
D
R
PI
VV
T
G
A
V
YN
LTKT
N
NLM
--------
A
D
P
EG
S
F
FS
V
EG
G
EI
R
A
R
GVEIE
AK
---
A
A
LS
A
S
VN
V
V
G
S
YT
YTD
AE
YTTD
T
TY
K
GN
TP
AQ
--------
V
P
K
H
MAS
LW
A
D
Y
TFF
D
G
P
LS
G
LT
L
G
T
G
G
RY
T
G
--
S
S
Y---G
D
-
P
A
-
-
N
-S
F
KV
GSY
T
VVDA
LV
RY
D
L
A
R
VGMAG
S
N
V
A
L
H
VNNLFD
RE
YVAS
CFN
T
-
Y
-------
GCFW
GA
E
R
Q
V
VA
TAT
FR
F
fig|444449.5.peg.4069
Escherichia coli O157:H7 str. EC4042
MAR
SKT
A
QPK
HSL
RKIAVV
V
A
T
AVS
G
MSVY
AQA
-
A
V
E
PK-
--
EDT
I
T
V
T
A
A
P
---
-
APQ
E
SA
WGPA
ATIAARQSAT
GTK
TDT
P
IQ
K
V
PQS
I
S
VV
T
A
E
E
M
A
LH
Q
PK
S
V
K
EAL
S
Y
TPGV
S
---
V
G
TR
G
A
S
N
T
Y
D
H
L
I
I
-
RGF
-
AAEG
Q
SQ
N
N
Y
L
N
G
L
KL
-------
Q
G
N
FYND
A
VI
D
PYML
ER
A
E
I
M
RGP
V
S
VL
YG
K
S
S
P
G
G
L
L
NMVSK
R
PT
T
EPL
K
-
E
V
QF
KA
G
T
DSLF
Q
TGF
D
FSDA
L
D
DDG
VY
S
Y
R
L
T
G
LA
RS
A
N
A
QQ
K
GSEE
Q
RY
AI
AP
A--
F
T
WR
PDDK
T
NFT
----------
F
L
SYF
Q
N
E--
-
---
P
E
T
G
YY
G
W-
LP
KE
GT
VEPL
--
P
N
GK
-
-
-----RL
P
T
D
F
N
E
GAK
N
NTY
S
R
NEKMVGYS
F
D
H
E
FNDT
F
T
V
R
Q
N
L
R
F
A
E
N
K
T
S
Q
--
NS
V
YG
-
-
Y
GVCS
D
PANAY
S
KQ
--------
CAALAPADKGHYLA
R
KYVVD
D
EKL
Q
N
F
SV
D
T
Q
L
Q
S
K
F
A
TG
D
I
D
H
T
L
L
---------------
TGV
D
F
M
R
MR
N
DIN
A
W
--------------------
F
G
YD
DSV
P
LLD
-
LY
N
PVN
T
D
-
FDFNAKDPA
N
SG
P
YRIL----
N
KQK
QT
---G
V
Y
V
Q
D
QA
Q
WDKV
L
V
T
L
GG
-
-
--
-
-
--
RYD
W
A
D
Q
------------
ESLNRVAGT
T
D
-----
KRDD
K
QF
TW
R
G
G
VN
Y
-
L
F
DNG
V
T
P
Y
F
SY
S
E
SF
E
-----
P
---------
S
S
-QV
---
G
K
D
G
NI
-
FAP
S
KG
K
Q
YE
V
G
V
K
YVPE
D
R
PI
VV
T
G
A
V
YN
LTKT
N
NLM
--------
A
D
P
EG
S
F
FS
V
EG
G
EI
R
A
R
GVEIE
AK
---
A
A
LS
A
S
VN
V
V
G
S
YT
YTD
AE
YTTD
T
TY
K
GN
TP
AQ
--------
V
P
K
H
MAS
LW
A
D
Y
TFF
D
G
P
LS
G
LT
L
G
T
G
G
RY
T
G
--
S
S
Y---G
D
-
P
A
-
-
N
-S
F
KV
GSY
T
VVDA
LV
RY
D
L
A
R
VGMAG
S
N
V
A
L
H
VNNLFD
RE
YVAS
CFN
T
-
Y
-------
GCFW
GA
E
R
Q
V
VA
TAT
FR
F
fig|444448.5.peg.2826
Escherichia coli O157:H7 str. EC4045
MAR
SKT
A
QPK
HSL
RKIAVV
V
A
T
AVS
G
MSVY
AQA
-
A
V
E
PK-
--
EDT
I
T
V
T
A
A
P
---
-
APQ
E
SA
WGPA
ATIAARQSAT
GTK
TDT
P
IQ
K
V
PQS
I
S
VV
T
A
E
E
M
A
LH
Q
PK
S
V
K
EAL
S
Y
TPGV
S
---
V
G
TR
G
A
S
N
T
Y
D
H
L
I
I
-
RGF
-
AAEG
Q
SQ
N
N
Y
L
N
G
L
KL
-------
Q
G
N
FYND
A
VI
D
PYML
ER
A
E
I
M
RGP
V
S
VL
YG
K
S
S
P
G
G
L
L
NMVSK
R
PT
T
EPL
K
-
E
V
QF
KA
G
T
DSLF
Q
TGF
D
FSDA
L
D
DDG
VY
S
Y
R
L
T
G
LA
RS
A
N
A
QQ
K
GSEE
Q
RY
AI
AP
A--
F
T
WR
PDDK
T
NFT
----------
F
L
SYF
Q
N
E--
-
---
P
E
T
G
YY
G
W-
LP
KE
GT
VEPL
--
P
N
GK
-
-
-----RL
P
T
D
F
N
E
GAK
N
NTY
S
R
NEKMVGYS
F
D
H
E
FNDT
F
T
V
R
Q
N
L
R
F
A
E
N
K
T
S
Q
--
NS
V
YG
-
-
Y
GVCS
D
PANAY
S
KQ
--------
CAALAPADKGHYLA
R
KYVVD
D
EKL
Q
N
F
SV
D
T
Q
L
Q
S
K
F
A
TG
D
I
D
H
T
L
L
---------------
TGV
D
F
M
R
MR
N
DIN
A
W
--------------------
F
G
YD
DSV
P
LLD
-
LY
N
PVN
T
D
-
FDFNAKDPA
N
SG
P
YRIL----
N
KQK
QT
---G
V
Y
V
Q
D
QA
Q
WDKV
L
V
T
L
GG
-
-
--
-
-
--
RYD
W
A
D
Q
------------
ESLNRVAGT
T
D
-----
KRDD
K
QF
TW
R
G
G
VN
Y
-
L
F
DNG
V
T
P
Y
F
SY
S
E
SF
E
-----
P
---------
S
S
-QV
---
G
K
D
G
NI
-
FAP
S
KG
K
Q
YE
V
G
V
K
YVPE
D
R
PI
VV
T
G
A
V
YN
LTKT
N
NLM
--------
A
D
P
EG
S
F
FS
V
EG
G
EI
R
A
R
GVEIE
AK
---
A
A
LS
A
S
VN
V
V
G
S
YT
YTD
AE
YTTD
T
TY
K
GN
TP
AQ
--------
V
P
K
H
MAS
LW
A
D
Y
TFF
D
G
P
LS
G
LT
L
G
T
G
G
RY
T
G
--
S
S
Y---G
D
-
P
A
-
-
N
-S
F
KV
GSY
T
VVDA
LV
RY
D
L
A
R
VGMAG
S
N
V
A
L
H
VNNLFD
RE
YVAS
CFN
T
-
Y
-------
GCFW
GA
E
R
Q
V
VA
TAT
FR
F
fig|444453.5.peg.3429
Escherichia coli O157:H7 str. EC4076
MAR
SKT
A
QPK
HSL
RKIAVV
V
A
T
AVS
G
MSVY
AQA
-
A
V
E
PK-
--
EDT
I
T
V
T
A
A
P
---
-
APQ
E
SA
WGPA
ATIAARQSAT
GTK
TDT
P
IQ
K
V
PQS
I
S
VV
T
A
E
E
M
A
LH
Q
PK
S
V
K
EAL
S
Y
TPGV
S
---
V
G
TR
G
A
S
N
T
Y
D
H
L
I
I
-
RGF
-
AAEG
Q
SQ
N
N
Y
L
N
G
L
KL
-------
Q
G
N
FYND
A
VI
D
PYML
ER
A
E
I
M
RGP
V
S
VL
YG
K
S
S
P
G
G
L
L
NMVSK
R
PT
T
EPL
K
-
E
V
QF
KA
G
T
DSLF
Q
TGF
D
FSDA
L
D
DDG
VY
S
Y
R
L
T
G
LA
RS
A
N
A
QQ
K
GSEE
Q
RY
AI
AP
A--
F
T
WR
PDDK
T
NFT
----------
F
L
SYF
Q
N
E--
-
---
P
E
T
G
YY
G
W-
LP
KE
GT
VEPL
--
P
N
GK
-
-
-----RL
P
T
D
F
N
E
GAK
N
NTY
S
R
NEKMVGYS
F
D
H
E
FNDT
F
T
V
R
Q
N
L
R
F
A
E
N
K
T
S
Q
--
NS
V
YG
-
-
Y
GVCS
D
PANAY
S
KQ
--------
CAALAPADKGHYLA
R
KYVVD
D
EKL
Q
N
F
SV
D
T
Q
L
Q
S
K
F
A
TG
D
I
D
H
T
L
L
---------------
TGV
D
F
M
R
MR
N
DIN
A
W
--------------------
F
G
YD
DSV
P
LLD
-
LY
N
PVN
T
D
-
FDFNAKDPA
N
SG
P
YRIL----
N
KQK
QT
---G
V
Y
V
Q
D
QA
Q
WDKV
L
V
T
L
GG
-
-
--
-
-
--
RYD
W
A
D
Q
------------
ESLNRVAGT
T
D
-----
KRDD
K
QF
TW
R
G
G
VN
Y
-
L
F
DNG
V
T
P
Y
F
SY
S
E
SF
E
-----
P
---------
S
S
-QV
---
G
K
D
G
NI
-
FAP
S
KG
K
Q
YE
V
G
V
K
YVPE
D
R
PI
VV
T
G
A
V
YN
LTKT
N
NLM
--------
A
D
P
EG
S
F
FS
V
EG
G
EI
R
A
R
GVEIE
AK
---
A
A
LS
A
S
VN
V
V
G
S
YT
YTD
AE
YTTD
T
TY
K
GN
TP
AQ
--------
V
P
K
H
MAS
LW
A
D
Y
TFF
D
G
P
LS
G
LT
L
G
T
G
G
RY
T
G
--
S
S
Y---G
D
-
P
A
-
-
N
-S
F
KV
GSY
T
VVDA
LV
RY
D
L
A
R
VGMAG
S
N
V
A
L
H
VNNLFD
RE
YVAS
CFN
T
-
Y
-------
GCFW
GA
E
R
Q
V
VA
TAT
FR
F
fig|444451.5.peg.4464
Escherichia coli O157:H7 str. EC4196
MAR
SKT
A
QPK
HSL
RKIAVV
V
A
T
AVS
G
MSVY
AQA
-
A
V
E
PK-
--
EDT
I
T
V
T
A
A
P
---
-
APQ
E
SA
WGPA
ATIAARQSAT
GTK
TDT
P
IQ
K
V
PQS
I
S
VV
T
A
E
E
M
A
LH
Q
PK
S
V
K
EAL
S
Y
TPGV
S
---
V
G
TR
G
A
S
N
T
Y
D
H
L
I
I
-
RGF
-
AAEG
Q
SQ
N
N
Y
L
N
G
L
KL
-------
Q
G
N
FYND
A
VI
D
PYML
ER
A
E
I
M
RGP
V
S
VL
YG
K
S
S
P
G
G
L
L
NMVSK
R
PT
T
EPL
K
-
E
V
QF
KA
G
T
DSLF
Q
TGF
D
FSDA
L
D
DDG
VY
S
Y
R
L
T
G
LA
RS
A
N
A
QQ
K
GSEE
Q
RY
AI
AP
A--
F
T
WR
PDDK
T
NFT
----------
F
L
SYF
Q
N
E--
-
---
P
E
T
G
YY
G
W-
LP
KE
GT
VEPL
--
P
N
GK
-
-
-----RL
P
T
D
F
N
E
GAK
N
NTY
S
R
NEKMVGYS
F
D
H
E
FNDT
F
T
V
R
Q
N
L
R
F
A
E
N
K
T
S
Q
--
NS
V
YG
-
-
Y
GVCS
D
PANAY
S
KQ
--------
CAALAPADKGHYLA
R
KYVVD
D
EKL
Q
N
F
SV
D
T
Q
L
Q
S
K
F
A
TG
D
I
D
H
T
L
L
---------------
TGV
D
F
M
R
MR
N
DIN
A
W
--------------------
F
G
YD
DSV
P
LLD
-
LY
N
PVN
T
D
-
FDFNAKDPA
N
SG
P
YRIL----
N
KQK
QT
---G
V
Y
V
Q
D
QA
Q
WDKV
L
V
T
L
GG
-
-
--
-
-
--
RYD
W
A
D
Q
------------
ESLNRVAGT
T
D
-----
KRDD
K
QF
TW
R
G
G
VN
Y
-
L
F
DNG
V
T
P
Y
F
SY
S
E
SF
E
-----
P
---------
S
S
-QV
---
G
K
D
G
NI
-
FAP
S
KG
K
Q
YE
V
G
V
K
YVPE
D
R
PI
VV
T
G
A
V
YN
LTKT
N
NLM
--------
A
D
P
EG
S
F
FS
V
EG
G
EI
R
A
R
GVEIE
AK
---
A
A
LS
A
S
VN
V
V
G
S
YT
YTD
AE
YTTD
T
TY
K
GN
TP
AQ
--------
V
P
K
H
MAS
LW
A
D
Y
TFF
D
G
P
LS
G
LT
L
G
T
G
G
RY
T
G
--
S
S
Y---G
D
-
P
A
-
-
N
-S
F
KV
GSY
T
VVDA
LV
RY
D
L
A
R
VGMAG
S
N
V
A
L
H
VNNLFD
RE
YVAS
CFN
T
-
Y
-------
GCFW
GA
E
R
Q
V
VA
TAT
FR
F
fig|478005.5.peg.4180
Escherichia coli O157:H7 str. EC4486
MAR
SKT
A
QPK
HSL
RKIAVV
V
A
T
AVS
G
MSVY
AQA
-
A
V
E
PK-
--
EDT
I
T
V
T
A
A
P
---
-
APQ
E
SA
WGPA
ATIAARQSAT
GTK
TDT
P
IQ
K
V
PQS
I
S
VV
T
A
E
E
M
A
LH
Q
PK
S
V
K
EAL
S
Y
TPGV
S
---
V
G
TR
G
A
S
N
T
Y
D
H
L
I
I
-
RGF
-
AAEG
Q
SQ
N
N
Y
L
N
G
L
KL
-------
Q
G
N
FYND
A
VI
D
PYML
ER
A
E
I
M
RGP
V
S
VL
YG
K
S
S
P
G
G
L
L
NMVSK
R
PT
T
EPL
K
-
E
V
QF
KA
G
T
DSLF
Q
TGF
D
FSDA
L
D
DDG
VY
S
Y
R
L
T
G
LA
RS
A
N
A
QQ
K
GSEE
Q
RY
AI
AP
A--
F
T
WR
PDDK
T
NFT
----------
F
L
SYF
Q
N
E--
-
---
P
E
T
G
YY
G
W-
LP
KE
GT
VEPL
--
P
N
GK
-
-
-----RL
P
T
D
F
N
E
GAK
N
NTY
S
R
NEKMVGYS
F
D
H
E
FNDT
F
T
V
R
Q
N
L
R
F
A
E
N
K
T
S
Q
--
NS
V
YG
-
-
Y
GVCS
D
PANAY
S
KQ
--------
CAALAPADKGHYLA
R
KYVVD
D
EKL
Q
N
F
SV
D
T
Q
L
Q
S
K
F
A
TG
D
I
D
H
T
L
L
---------------
TGV
D
F
M
R
MR
N
DIN
A
W
--------------------
F
G
YD
DSV
P
LLD
-
LY
N
PVN
T
D
-
FDFNAKDPA
N
SG
P
YRIL----
N
KQK
QT
---G
V
Y
V
Q
D
QA
Q
WDKV
L
V
T
L
GG
-
-
--
-
-
--
RYD
W
A
D
Q
------------
ESLNRVAGT
T
D
-----
KRDD
K
QF
TW
R
G
G
VN
Y
-
L
F
DNG
V
T
P
Y
F
SY
S
E
SF
E
-----
P
---------
S
S
-QV
---
G
K
D
G
NI
-
FAP
S
KG
K
Q
YE
V
G
V
K
YVPE
D
R
PI
VV
T
G
A
V
YN
LTKT
N
NLM
--------
A
D
P
EG
S
F
FS
V
EG
G
EI
R
A
R
GVEIE
AK
---
A
A
LS
A
S
VN
V
V
G
S
YT
YTD
AE
YTTD
T
TY
K
GN
TP
AQ
--------
V
P
K
H
MAS
LW
A
D
Y
TFF
D
G
P
LS
G
LT
L
G
T
G
G
RY
T
G
--
S
S
Y---G
D
-
P
A
-
-
N
-S
F
KV
GSY
T
VVDA
LV
RY
D
L
A
R
VGMAG
S
N
V
A
L
H
VNNLFD
RE
YVAS
CFN
T
-
Y
-------
GCFW
GA
E
R
Q
V
VA
TAT
FR
F
fig|478007.5.peg.4883
Escherichia coli O157:H7 str. EC508
MAR
SKT
A
QPK
HSL
RKIAVV
V
A
T
AVS
G
MSVY
AQA
-
A
V
E
PK-
--
EDT
I
T
V
T
A
A
P
---
-
APQ
E
SA
WGPA
ATIAARQSAT
GTK
TDT
P
IQ
K
V
PQS
I
S
VV
T
A
E
E
M
A
LH
Q
PK
S
V
K
EAL
S
Y
TPGV
S
---
V
G
TR
G
A
S
N
T
Y
D
H
L
I
I
-
RGF
-
AAEG
Q
SQ
N
N
Y
L
N
G
L
KL
-------
Q
G
N
FYND
A
VI
D
PYML
ER
A
E
I
M
RGP
V
S
VL
YG
K
S
S
P
G
G
L
L
NMVSK
R
PT
T
EPL
K
-
E
V
QF
KA
G
T
DSLF
Q
TGF
D
FSDA
L
D
DDG
VY
S
Y
R
L
T
G
LA
RS
A
N
A
QQ
K
GSEE
Q
RY
AI
AP
A--
F
T
WR
PDDK
T
NFT
----------
F
L
SYF
Q
N
E--
-
---
P
E
T
G
YY
G
W-
LP
KE
GT
VEPL
--
P
N
GK
-
-
-----RL
P
T
D
F
N
E
GAK
N
NTY
S
R
NEKMVGYS
F
D
H
E
FNDT
F
T
V
R
Q
N
L
R
F
A
E
N
K
T
S
Q
--
NS
V
YG
-
-
Y
GVCS
D
PANAY
S
KQ
--------
CAALAPADKGHYLA
R
KYVVD
D
EKL
Q
N
F
SV
D
T
Q
L
Q
S
K
F
A
TG
D
I
D
H
T
L
L
---------------
TGV
D
F
M
R
MR
N
DIN
A
W
--------------------
F
G
YD
DSV
P
LLD
-
LY
N
PVN
T
D
-
FDFNAKDPA
N
SG
P
YRIL----
N
KQK
QT
---G
V
Y
V
Q
D
QA
Q
WDKV
L
V
T
L
GG
-
-
--
-
-
--
RYD
W
A
D
Q
------------
ESLNRVAGT
T
D
-----
KRDD
K
QF
TW
R
G
G
VN
Y
-
L
F
DNG
V
T
P
Y
F
SY
S
E
SF
E
-----
P
---------
S
S
-QV
---
G
K
D
G
NI
-
FAP
S
KG
K
Q
YE
V
G
V
K
YVPE
D
R
PI
VV
T
G
A
V
YN
LTKT
N
NLM
--------
A
D
P
EG
S
F
FS
V
EG
G
EI
R
A
R
GVEIE
AK
---
A
A
LS
A
S
VN
V
V
G
S
YT
YTD
AE
YTTD
T
TY
K
GN
TP
AQ
--------
V
P
K
H
MAS
LW
A
D
Y
TFF
D
G
P
LS
G
LT
L
G
T
G
G
RY
T
G
--
S
S
Y---G
D
-
P
A
-
-
N
-S
F
KV
GSY
T
VVDA
LV
RY
D
L
A
R
VGMAG
S
N
V
A
L
H
VNNLFD
RE
YVAS
CFN
T
-
Y
-------
GCFW
GA
E
R
Q
V
VA
TAT
FR
F
fig|478008.5.peg.4347
Escherichia coli O157:H7 str. EC869
MAR
SKT
A
QPK
HSL
RKIAVV
V
A
T
AVS
G
MSVY
AQA
-
A
V
E
PK-
--
EDT
I
T
V
T
A
A
P
---
-
APQ
E
SA
WGPA
ATIAARQSAT
GTK
TDT
P
IQ
K
V
PQS
I
S
VV
T
A
E
E
M
A
LH
Q
PK
S
V
K
EAL
S
Y
TPGV
S
---
V
G
TR
G
A
S
N
T
Y
D
H
L
I
I
-
RGF
-
AAEG
Q
SQ
N
N
Y
L
N
G
L
KL
-------
Q
G
N
FYND
A
VI
D
PYML
ER
A
E
I
M
RGP
V
S
VL
YG
K
S
S
P
G
G
L
L
NMVSK
R
PT
T
EPL
K
-
E
V
QF
KA
G
T
DSLF
Q
TGF
D
FSDA
L
D
DDG
VY
S
Y
R
L
T
G
LA
RS
A
N
A
QQ
K
GSEE
Q
RY
AI
AP
A--
F
T
WR
PDDK
T
NFT
----------
F
L
SYF
Q
N
E--
-
---
P
E
T
G
YY
G
W-
LP
KE
GT
VEPL
--
P
N
GK
-
-
-----RL
P
T
D
F
N
E
GAK
N
NTY
S
R
NEKMVGYS
F
D
H
E
FNDT
F
T
V
R
Q
N
L
R
F
A
E
N
K
T
S
Q
--
NS
V
YG
-
-
Y
GVCS
D
PANAY
S
KQ
--------
CAALAPADKGHYLA
R
KYVVD
D
EKL
Q
N
F
SV
D
T
Q
L
Q
S
K
F
A
TG
D
I
D
H
T
L
L
---------------
TGV
D
F
M
R
MR
N
DIN
A
W
--------------------
F
G
YD
DSV
P
LLD
-
LY
N
PVN
T
D
-
FDFNAKDPA
N
SG
P
YRIL----
N
KQK
QT
---G
V
Y
V
Q
D
QA
Q
WDKV
L
V
T
L
GG
-
-
--
-
-
--
RYD
W
A
D
Q
------------
ESLNRVAGT
T
D
-----
KRDD
K
QF
TW
R
G
G
VN
Y
-
L
F
DNG
V
T
P
Y
F
SY
S
E
SF
E
-----
P
---------
S
S
-QV
---
G
K
D
G
NI
-
FAP
S
KG
K
Q
YE
V
G
V
K
YVPE
D
R
PI
VV
T
G
A
V
YN
LTKT
N
NLM
--------
A
D
P
EG
S
F
FS
V
EG
G
EI
R
A
R
GVEIE
AK
---
A
A
LS
A
S
VN
V
V
G
S
YT
YTD
AE
YTTD
T
TY
K
GN
TP
AQ
--------
V
P
K
H
MAS
LW
A
D
Y
TFF
D
G
P
LS
G
LT
L
G
T
G
G
RY
T
G
--
S
S
Y---G
D
-
P
A
-
-
N
-S
F
KV
GSY
T
VVDA
LV
RY
D
L
A
R
VGMAG
S
N
V
A
L
H
VNNLFD
RE
YVAS
CFN
T
-
Y
-------
GCFW
GA
E
R
Q
V
VA
TAT
FR
F
fig|570506.3.peg.1157
Escherichia coli O157:H7 str. FRIK966
MAR
SKT
A
QPK
HSL
RKIAVV
V
A
T
AVS
G
MSVY
AQA
-
A
V
E
PK-
--
EDT
I
T
V
T
A
A
P
---
-
APQ
E
SA
WGPA
ATIAARQSAT
GTK
TDT
P
IQ
K
V
PQS
I
S
VV
T
A
E
E
M
A
LH
Q
PK
S
V
K
EAL
S
Y
TPGV
S
---
V
G
TR
G
A
S
N
T
Y
D
H
L
I
I
-
RGF
-
AAEG
Q
SQ
N
N
Y
L
N
G
L
KL
-------
Q
G
N
FYND
A
VI
D
PYML
ER
A
E
I
M
RGP
V
S
VL
YG
K
S
S
P
G
G
L
L
NMVSK
R
PT
T
EPL
K
-
E
V
QF
KA
G
T
DSLF
Q
TGF
D
FSDA
L
D
DDG
VY
S
Y
R
L
T
G
LA
RS
A
N
A
QQ
K
GSEE
Q
RY
AI
AP
A--
F
T
WR
PDDK
T
NFT
----------
F
L
SYF
Q
N
E--
-
---
P
E
T
G
YY
G
W-
LP
KE
GT
VEPL
--
P
N
GK
-
-
-----RL
P
T
D
F
N
E
GAK
N
NTY
S
R
NEKMVGYS
F
D
H
E
FNDT
F
T
V
R
Q
N
L
R
F
A
E
N
K
T
S
Q
--
NS
V
YG
-
-
Y
GVCS
D
PANAY
S
KQ
--------
CAALAPADKGHYLA
R
KYVVD
D
EKL
Q
N
F
SV
D
T
Q
L
Q
S
K
F
A
TG
D
I
D
H
T
L
L
---------------
TGV
D
F
M
R
MR
N
DIN
A
W
--------------------
F
G
YD
DSV
P
LLD
-
LY
N
PVN
T
D
-
FDFNAKDPA
N
SG
P
YRIL----
N
KQK
QT
---G
V
Y
V
Q
D
QA
Q
WDKV
L
V
T
L
GG
-
-
--
-
-
--
RYD
W
A
D
Q
------------
ESLNRVAGT
T
D
-----
KRDD
K
QF
TW
R
G
G
VN
Y
-
L
F
DNG
V
T
P
Y
F
SY
S
E
SF
E
-----
P
---------
S
S
-QV
---
G
K
D
G
NI
-
FAP
S
KG
K
Q
YE
V
G
V
K
YVPE
D
R
PI
VV
T
G
A
V
YN
LTKT
N
NLM
--------
A
D
P
EG
S
F
FS
V
EG
G
EI
R
A
R
GVEIE
AK
---
A
A
LS
A
S
VN
V
V
G
S
YT
YTD
AE
YTTD
T
TY
K
GN
TP
AQ
--------
V
P
K
H
MAS
LW
A
D
Y
TFF
D
G
P
LS
G
LT
L
G
T
G
G
RY
T
G
--
S
S
Y---G
D
-
P
A
-
-
N
-S
F
KV
GSY
T
VVDA
LV
RY
D
L
A
R
VGMAG
S
N
V
A
L
H
VNNLFD
RE
YVAS
CFN
T
-
Y
-------
GCFW
GA
E
R
Q
V
VA
TAT
FR
F
fig|544404.4.peg.158
Escherichia coli O157:H7 str. TW14359
MAR
SKT
A
QPK
HSL
RKIAVV
V
A
T
AVS
G
MSVY
AQA
-
A
V
E
PK-
--
EDT
I
T
V
T
A
A
P
---
-
APQ
E
SA
WGPA
ATIAARQSAT
GTK
TDT
P
IQ
K
V
PQS
I
S
VV
T
A
E
E
M
A
LH
Q
PK
S
V
K
EAL
S
Y
TPGV
S
---
V
G
TR
G
A
S
N
T
Y
D
H
L
I
I
-
RGF
-
AAEG
Q
SQ
N
N
Y
L
N
G
L
KL
-------
Q
G
N
FYND
A
VI
D
PYML
ER
A
E
I
M
RGP
V
S
VL
YG
K
S
S
P
G
G
L
L
NMVSK
R
PT
T
EPL
K
-
E
V
QF
KA
G
T
DSLF
Q
TGF
D
FSDA
L
D
DDG
VY
S
Y
R
L
T
G
LA
RS
A
N
A
QQ
K
GSEE
Q
RY
AI
AP
A--
F
T
WR
PDDK
T
NFT
----------
F
L
SYF
Q
N
E--
-
---
P
E
T
G
YY
G
W-
LP
KE
GT
VEPL
--
P
N
GK
-
-
-----RL
P
T
D
F
N
E
GAK
N
NTY
S
R
NEKMVGYS
F
D
H
E
FNDT
F
T
V
R
Q
N
L
R
F
A
E
N
K
T
S
Q
--
NS
V
YG
-
-
Y
GVCS
D
PANAY
S
KQ
--------
CAALAPADKGHYLA
R
KYVVD
D
EKL
Q
N
F
SV
D
T
Q
L
Q
S
K
F
A
TG
D
I
D
H
T
L
L
---------------
TGV
D
F
M
R
MR
N
DIN
A
W
--------------------
F
G
YD
DSV
P
LLD
-
LY
N
PVN
T
D
-
FDFNAKDPA
N
SG
P
YRIL----
N
KQK
QT
---G
V
Y
V
Q
D
QA
Q
WDKV
L
V
T
L
GG
-
-
--
-
-
--
RYD
W
A
D
Q
------------
ESLNRVAGT
T
D
-----
KRDD
K
QF
TW
R
G
G
VN
Y
-
L
F
DNG
V
T
P
Y
F
SY
S
E
SF
E
-----
P
---------
S
S
-QV
---
G
K
D
G
NI
-
FAP
S
KG
K
Q
YE
V
G
V
K
YVPE
D
R
PI
VV
T
G
A
V
YN
LTKT
N
NLM
--------
A
D
P
EG
S
F
FS
V
EG
G
EI
R
A
R
GVEIE
AK
---
A
A
LS
A
S
VN
V
V
G
S
YT
YTD
AE
YTTD
T
TY
K
GN
TP
AQ
--------
V
P
K
H
MAS
LW
A
D
Y
TFF
D
G
P
LS
G
LT
L
G
T
G
G
RY
T
G
--
S
S
Y---G
D
-
P
A
-
-
N
-S
F
KV
GSY
T
VVDA
LV
RY
D
L
A
R
VGMAG
S
N
V
A
L
H
VNNLFD
RE
YVAS
CFN
T
-
Y
-------
GCFW
GA
E
R
Q
V
VA
TAT
FR
F
fig|749537.3.peg.3254
Escherichia coli MS 115-1
MAR
SKT
A
QPK
HSL
RKIAVV
V
A
T
AVS
G
MSVY
AQA
-
A
V
E
PK-
--
EDT
I
T
V
T
A
A
P
---
-
APQ
E
SA
WGPA
ATIAARQSAT
GTK
TDT
P
IQ
K
V
PQS
I
S
VV
T
A
E
E
M
A
LH
Q
PK
S
V
K
EAL
S
Y
TPGV
S
---
V
G
TR
G
A
S
N
T
Y
D
H
L
I
I
-
RGF
-
AAEG
Q
SQ
N
N
Y
L
N
G
L
KL
-------
Q
G
N
FYND
A
VI
D
PYML
ER
A
E
I
M
RGP
V
S
VL
YG
K
S
S
P
G
G
L
L
NMVSK
R
PT
T
EPL
K
-
E
V
QF
KA
G
T
DSLF
Q
TGF
D
FSDA
L
D
DDG
VY
S
Y
R
L
T
G
LA
RS
A
N
A
QQ
K
GSEE
Q
RY
AI
AP
A--
F
T
WR
PDDK
T
NFT
----------
V
L
SYF
Q
N
E--
-
---
P
E
T
G
YY
G
W-
LP
KE
GT
VEPL
--
P
N
GK
-
-
-----RL
P
T
D
F
N
E
GAK
N
NTY
S
R
NEKMVGYS
F
D
H
E
FNDT
F
T
V
R
Q
N
L
R
F
A
E
N
K
T
S
Q
--
NS
V
YG
-
-
Y
GVCS
D
PANAY
S
KQ
--------
CAALAPADKGHYLA
R
KYVVD
D
EKL
Q
N
F
SV
D
T
Q
L
Q
S
K
F
A
TG
D
I
D
H
T
L
L
---------------
TGV
D
F
M
R
MR
N
DIN
A
W
--------------------
F
G
YD
DSV
P
LLN
-
LY
N
PVN
T
D
-
FDFNAKDPA
N
SG
P
YRIL----
N
KQK
QT
---G
V
Y
V
Q
D
QA
Q
WDKV
L
V
T
L
GG
-
-
--
-
-
--
RYD
W
A
D
Q
------------
ESLNRVAGT
T
D
-----
KRDD
K
QF
TW
R
G
G
VN
Y
-
L
F
DNG
V
T
P
Y
F
SY
S
E
SF
E
-----
P
---------
S
S
-QV
---
G
K
D
G
NI
-
FAP
S
KG
K
Q
YE
V
G
V
K
YVPE
D
R
PI
VV
T
G
A
V
YN
LTKT
N
NLM
--------
A
D
P
EG
S
F
FS
V
EG
G
EI
R
A
R
GVEIE
AK
---
A
A
LS
A
S
VN
V
V
G
S
YT
YTD
AE
YTTD
T
TY
K
GN
TP
AQ
--------
V
P
K
H
MAS
LW
A
D
Y
TFF
D
G
P
LS
G
LT
L
G
T
G
G
RY
T
G
--
S
S
Y---G
D
-
P
A
-
-
N
-S
F
KV
GSY
T
VVDA
LV
RY
D
L
A
R
VGMAG
S
N
V
A
L
H
VNNLFD
RE
YVAS
CFN
T
-
Y
-------
GCFW
GA
E
R
Q
V
VA
TAT
FR
F
fig|749531.3.peg.4461
Escherichia coli MS 69-1
MAR
SKT
A
QPK
HSL
RKIAVV
V
A
T
AVS
G
MSVY
AQA
-
A
V
E
PK-
--
EDT
I
T
V
T
A
A
P
---
-
APQ
E
SA
WGPA
ATIAARQSAT
GTK
TDT
P
IQ
K
V
PQS
I
S
VV
T
A
E
E
M
A
LH
Q
PK
S
V
K
EAL
S
Y
TPGV
S
---
V
G
TR
G
A
S
N
T
Y
D
H
L
I
I
-
RGF
-
AAEG
Q
SQ
N
N
Y
L
N
G
L
KL
-------
Q
G
N
FYND
A
VI
D
PYML
ER
A
E
I
M
RGP
V
S
VL
YG
K
S
S
P
G
G
L
L
NMVSK
R
PT
T
EPL
K
-
E
V
QF
KA
G
T
DSLF
Q
TGF
D
FSDA
L
D
DDG
VY
S
Y
R
L
T
G
LA
RS
A
N
A
QQ
K
GSEE
Q
RY
AI
AP
A--
F
T
WR
PDDK
T
NFT
----------
F
L
SYF
Q
N
E--
-
---
P
E
T
G
YY
G
W-
LP
KE
GT
VEPL
--
P
N
GK
-
-
-----RL
P
T
D
F
N
E
GAK
N
NTY
S
R
NEKMVGYS
F
D
H
E
FNDT
F
T
V
R
Q
N
L
R
F
A
E
N
K
T
S
Q
--
NS
V
YG
-
-
Y
GVCS
D
PANAY
S
KQ
--------
CAALAPADKGHYLA
R
KYVVD
D
EKL
Q
N
F
SV
D
T
Q
L
Q
S
K
F
A
TG
D
I
D
H
T
L
L
---------------
TGV
D
F
M
R
MR
N
DIN
A
W
--------------------
F
G
YD
DSV
P
LLD
-
LY
N
PVN
T
D
-
FDFNAKDPD
N
SG
P
YRIL----
N
KQK
QT
---G
V
Y
V
Q
D
QA
Q
WDKV
L
V
T
L
GG
-
-
--
-
-
--
RYD
W
A
D
Q
------------
ESLNRVAGT
T
D
-----
KRDD
K
QF
TW
R
G
G
VN
Y
-
L
F
DNG
V
T
P
Y
F
SY
S
E
SF
E
-----
P
---------
S
S
-QV
---
G
K
D
G
NI
-
FAP
S
KG
K
Q
YE
V
G
V
K
YVPE
D
R
PI
VV
T
G
A
V
YN
LTKT
N
NLM
--------
A
D
P
EG
S
F
FS
V
EG
G
EI
R
A
R
GVEIE
AK
---
A
A
LS
A
S
VN
V
V
G
S
YT
YTD
AE
YTTD
T
TY
K
GN
TP
AQ
--------
V
P
K
H
MAS
LW
A
D
Y
TFF
D
G
P
LS
G
LT
L
G
T
G
G
RY
T
G
--
S
S
Y---G
D
-
P
A
-
-
N
-S
F
KV
GSY
T
VVDA
LV
RY
D
L
A
R
VGMAG
S
N
V
A
L
H
VNNLFD
RE
YVAS
CFN
T
-
Y
-------
GCFW
GA
E
R
Q
V
VA
TAT
FR
F
fig|656444.3.peg.491
Escherichia coli TA280
MAR
SKT
A
QPK
HSL
RKIAVV
V
A
T
AVS
G
MSVY
AQA
-
A
V
E
PK-
--
EDT
I
T
V
T
A
A
P
---
-
APQ
E
SA
WGPA
ATIAARQSAT
GTK
TDT
P
IQ
K
V
PQS
I
S
VV
T
A
E
E
M
A
LH
Q
PK
S
V
K
EAL
S
Y
TPGV
S
---
V
G
TR
G
A
S
N
T
Y
D
H
L
I
I
-
RGF
-
AAEG
Q
SQ
N
N
Y
L
N
G
L
KL
-------
Q
G
N
FYND
A
VI
D
PYML
ER
A
E
I
M
RGP
V
S
VL
YG
K
S
S
P
G
G
L
L
NMVSK
R
PT
T
EPL
K
-
E
V
QF
KA
G
T
DSLF
Q
TGF
D
FSDA
L
D
DDG
VY
S
Y
R
L
T
G
LA
RS
A
N
A
QQ
K
GSEE
Q
RY
AI
AP
A--
F
S
WR
PDDK
T
NFT
----------
F
L
SYF
Q
N
E--
-
---
P
E
T
G
YY
G
W-
LP
KE
GT
VEPL
--
P
N
GK
-
-
-----RL
P
T
D
F
N
E
GAK
N
NTY
S
R
NEKMVGYS
F
D
H
E
FNDT
F
T
V
R
Q
N
L
R
F
A
E
N
K
T
S
Q
--
NS
V
YG
-
-
Y
GVCS
D
PANAY
S
KQ
--------
CAALAPADKGHYLA
R
KYVVD
D
EKL
Q
N
F
SV
D
T
Q
L
Q
S
Q
F
A
TG
D
I
D
H
T
L
L
---------------
TGV
D
F
M
R
MR
N
DIN
A
W
--------------------
F
G
YD
DS
I
P
LLD
-
LY
N
PVN
T
D
-
FDFNAKDPA
N
SG
P
YRIL----
N
KQK
QT
---G
V
Y
V
Q
D
QA
Q
WDKV
L
V
T
L
GG
-
-
--
-
-
--
RYD
W
A
D
Q
------------
ESLNRVAGT
T
D
-----
KRDD
K
QF
TW
R
G
G
VN
Y
-
L
F
DNG
V
T
P
Y
F
SY
S
E
SF
E
-----
P
---------
S
S
-QV
---
G
K
D
G
NI
-
FAP
S
KG
K
Q
YE
V
G
V
K
YVPE
D
R
PI
VV
T
G
A
V
YN
LTKT
N
NLM
--------
A
D
P
EG
S
F
FS
V
EG
G
EI
R
A
R
GVEIE
AK
---
A
A
LS
A
S
VN
V
V
G
S
YT
YTD
AE
YTTD
T
TY
K
GN
TP
AQ
--------
V
P
K
H
MAS
LW
A
D
Y
TFF
D
G
P
LS
G
LT
L
G
T
G
G
RY
T
G
--
S
S
Y---G
D
-
P
A
-
-
N
-S
F
KV
GSY
T
VVDA
LV
RY
D
L
A
R
VGMAG
S
N
V
A
L
H
VNNLFD
RE
YVAS
CFN
T
-
Y
-------
GCFW
GA
E
R
Q
V
VA
TAT
FR
F
fig|550677.3.peg.540
Escherichia coli B354
MAR
SKT
A
QPK
HSL
RKIAVV
V
A
T
AVS
G
MSVY
AQA
-
A
V
E
PK-
--
EDT
I
T
V
T
A
A
P
---
-
APQ
E
SA
WGPA
ATIAARQSAT
GTK
TDT
P
IQ
K
V
PQS
I
S
VV
T
A
E
E
M
A
LH
Q
PK
S
V
K
EAL
S
Y
TPGV
S
---
V
G
TR
G
A
S
N
T
Y
D
H
L
I
I
-
RGF
-
AAEG
Q
SQ
N
N
Y
L
N
G
L
KL
-------
Q
G
N
FYND
A
VI
D
PYML
ER
A
E
I
M
RGP
V
S
VL
YG
K
S
S
P
G
G
L
L
NMVSK
R
PT
T
EPL
K
-
E
V
QF
KA
G
T
DSLF
Q
TGF
D
FSDA
L
D
DDG
VY
S
Y
R
L
I
G
LA
RS
A
N
A
QQ
K
GSEE
Q
RY
AI
AP
A--
F
T
WR
PDDK
T
NFT
----------
F
L
SYF
Q
N
E--
-
---
P
E
T
G
YY
G
W-
LP
KE
GT
VEPL
--
P
N
GK
-
-
-----RL
P
T
D
F
N
E
GAK
N
NTY
S
R
NEKMVGYS
F
D
H
E
FNDT
F
T
V
R
Q
N
L
R
F
A
E
N
K
T
S
Q
--
NS
V
YG
-
-
Y
GVCS
D
PANAY
S
KQ
--------
CAALAPADKGHYLA
R
KYVVD
D
EKL
Q
N
F
SV
D
T
Q
L
Q
S
Q
F
A
TG
D
I
D
H
T
L
L
---------------
TGV
D
F
M
R
MR
N
DIN
A
W
--------------------
F
G
YD
DSV
P
LLD
-
LY
N
PVN
T
D
-
FDFNAKDPA
N
SG
P
YRIL----
N
KQK
QT
---G
V
Y
V
Q
D
QA
Q
WDKV
L
V
T
L
GG
-
-
--
-
-
--
RYD
W
A
D
Q
------------
ESLNRVAGT
T
D
-----
KRDD
K
QF
TW
R
G
G
VN
Y
-
L
F
DNG
V
T
P
Y
F
SY
S
E
SF
E
-----
P
---------
S
S
-QV
---
G
K
D
G
NI
-
FAP
S
KG
K
Q
YE
V
G
V
K
YVPE
D
R
PI
VV
T
G
A
V
YN
LTKT
N
NLM
--------
A
D
P
EG
S
F
FS
V
EG
G
EI
R
A
R
GVEIE
AK
---
A
A
LS
A
S
VN
V
V
G
S
YT
YTD
AE
YTTD
T
TY
K
GN
TP
AQ
--------
V
P
K
H
MAS
LW
A
D
Y
TFF
D
G
P
LS
G
LT
L
G
T
G
G
RY
T
G
--
S
S
Y---G
D
-
P
A
-
-
N
-S
F
KV
GSY
T
VVDA
LV
RY
D
L
A
R
VGMAG
S
N
V
A
L
H
VNNLFD
RE
YVAS
CFN
T
-
Y
-------
GCFW
GA
E
R
Q
V
VA
TAT
FR
F
fig|656437.3.peg.218
Escherichia coli TA143
MAR
SKT
A
QPK
HSL
RKIAVV
V
A
T
AVS
G
MSVY
AQA
-
A
V
E
PK-
--
EDT
I
T
V
T
A
A
P
---
-
APQ
E
SA
WGPA
ATIAARQSAT
GTK
TDT
P
IQ
K
V
PQS
I
S
VV
T
A
E
E
M
A
LH
Q
PK
S
V
K
EAL
S
Y
TPGV
S
---
V
G
TR
G
A
S
N
T
Y
D
H
L
I
I
-
RGF
-
AAEG
Q
SQ
N
N
Y
L
N
G
L
KL
-------
Q
G
N
FYND
A
VI
D
PYML
ER
A
E
I
M
RGP
V
S
VL
YG
K
S
S
P
G
G
L
L
NMVSK
R
PT
T
EPL
K
-
E
V
QF
KA
G
T
DSLF
Q
TGF
D
FSDA
L
D
DDG
VY
S
Y
R
L
T
G
LA
RS
A
N
A
QQ
K
GSEE
Q
RY
AI
AP
A--
F
T
WR
PDDK
T
NFT
----------
F
L
SYF
Q
N
E--
-
---
P
E
T
G
YY
G
W-
LP
KE
GT
VEPL
--
P
N
GK
-
-
-----RL
P
T
D
F
N
E
GAK
N
NTY
S
R
NEKMVGYS
F
D
H
E
FNDT
F
T
V
R
Q
N
L
R
F
A
E
N
K
T
S
Q
--
NS
V
YG
-
-
Y
GVCS
D
PANAY
S
KQ
--------
CAALAPADKGHYLA
R
KYVVD
D
EKL
Q
N
F
SV
D
T
Q
L
Q
S
K
F
A
TG
D
I
D
H
T
L
L
---------------
TGV
D
F
M
R
MR
N
DIN
A
W
--------------------
F
G
YD
DSV
P
LLD
-
LY
N
PVN
T
D
-
FDFNAKDPD
N
SG
P
YRIL----
N
KQK
QT
---G
V
Y
V
Q
D
QA
Q
WDKV
L
V
T
L
GG
-
-
--
-
-
--
RYD
W
A
D
Q
------------
ESLNRVAGT
T
D
-----
KRDD
K
QF
TW
R
G
G
VN
Y
-
L
F
DNG
V
T
P
Y
F
SY
S
E
SF
E
-----
P
---------
S
S
-QV
---
G
K
D
G
NI
-
FAP
S
KG
K
Q
YE
V
G
V
K
YVPE
D
R
PI
VV
T
G
A
V
YN
LTKT
N
NLM
--------
A
D
P
EG
S
F
FS
V
EG
G
EI
R
A
R
GVEIE
AK
---
A
A
LS
A
S
VN
V
V
G
S
YT
YTD
AE
YTTD
T
TY
K
GN
TP
AQ
--------
V
P
K
H
MAS
LW
A
D
Y
TFF
D
G
P
LS
G
LT
L
G
T
G
G
RY
T
G
--
S
S
Y---G
D
-
P
T
-
-
N
-S
F
KV
GSY
T
VVDA
LV
RY
D
L
A
R
VGMAG
S
N
V
A
L
H
VNNLFD
RE
YVAS
CFN
T
-
Y
-------
GCFW
GA
E
R
Q
V
VA
TAT
FR
F
fig|562.371.peg.892
Escherichia coli 1044A
MAR
SKT
A
QPK
HSL
RKIAVV
V
A
T
AVS
G
MSVY
AQA
-
A
V
E
LK-
--
EDT
I
T
V
T
A
A
P
---
-
APQ
E
SA
WGPA
ATIAARQSAT
GTK
TDT
P
IQ
K
V
PQS
I
S
VV
T
A
E
E
M
A
LH
Q
PK
S
V
K
EAL
S
Y
TPGV
S
---
V
G
TR
G
A
S
N
T
Y
D
H
L
I
I
-
RGF
-
AAEG
Q
SQ
N
N
Y
L
N
G
L
KL
-------
Q
G
N
FYND
A
VI
D
PYML
ER
A
E
I
M
RGP
V
S
VL
YG
K
S
S
P
G
G
L
L
NMVSK
R
PT
T
EPL
K
-
E
V
QF
KA
G
T
DSLF
Q
TGF
D
FSDA
L
D
DDG
VY
S
Y
R
L
T
G
LA
RS
A
N
A
QQ
K
GSEE
Q
RY
AI
AP
A--
F
T
WR
PDDK
T
NFT
----------
F
L
SYF
Q
N
E--
-
---
P
E
T
G
YY
G
W-
LP
KE
GT
VEPL
--
P
N
GK
-
-
-----RL
P
T
D
F
N
E
GAK
N
NTY
S
R
NEKMVGYS
F
D
H
E
FNDT
F
T
V
R
Q
N
L
R
F
A
E
N
K
T
S
Q
--
NS
V
YG
-
-
Y
GVCS
D
PANAY
S
KQ
--------
CAALAPADKGHYLA
R
KYVVD
D
EKL
Q
N
F
SV
D
T
Q
L
Q
S
K
F
A
TG
D
I
D
H
T
L
L
---------------
TGV
D
F
M
R
MR
N
DIN
A
W
--------------------
F
G
YD
DSV
P
LLD
-
LY
N
PVN
T
D
-
FDFNAKDPA
N
SG
P
YRIL----
N
KQK
QT
---G
V
Y
V
Q
D
QA
Q
WDKV
L
V
T
L
GG
-
-
--
-
-
--
RYD
W
A
D
Q
------------
ESLNRVAGT
T
D
-----
KRDD
K
QF
TW
R
G
G
VN
Y
-
L
F
DNG
V
T
P
Y
F
SY
S
E
SF
E
-----
P
---------
S
S
-QV
---
G
K
D
G
NI
-
FAP
S
KG
K
Q
YE
V
G
V
K
YVPE
D
R
PI
VV
T
G
A
V
YN
LTKT
N
NLM
--------
A
D
P
EG
S
F
FS
V
EG
G
EI
R
A
R
GVEIE
AK
---
A
A
LS
A
S
VN
V
V
G
S
YT
YTD
AE
YTTD
T
TY
K
GN
TP
AQ
--------
V
P
K
H
MAS
LW
A
D
Y
TFF
D
G
P
LS
G
LT
L
G
T
G
G
RY
T
G
--
S
S
Y---G
D
-
P
A
-
-
N
-S
F
KV
GSY
T
VVDA
LV
RY
D
L
A
R
VGMAG
S
N
V
A
L
H
VNNLFD
RE
YVAS
CFN
T
-
Y
-------
GCFW
GA
E
R
Q
V
VA
TAT
FR
F
fig|83334.1.peg.242
Escherichia coli O157:H7
MAR
SKT
A
QPK
HSL
RKIAVV
V
A
T
AVS
G
MSVY
AQA
-
A
V
E
LK-
--
EDT
I
T
V
T
A
A
P
---
-
APQ
E
SA
WGPA
ATIAARQSAT
GTK
TDT
P
IQ
K
V
PQS
I
S
VV
T
A
E
E
M
A
LH
Q
PK
S
V
K
EAL
S
Y
TPGV
S
---
V
G
TR
G
A
S
N
T
Y
D
H
L
I
I
-
RGF
-
AAEG
Q
SQ
N
N
Y
L
N
G
L
KL
-------
Q
G
N
FYND
A
VI
D
PYML
ER
A
E
I
M
RGP
V
S
VL
YG
K
S
S
P
G
G
L
L
NMVSK
R
PT
T
EPL
K
-
E
V
QF
KA
G
T
DSLF
Q
TGF
D
FSDA
L
D
DDG
VY
S
Y
R
L
T
G
LA
RS
A
N
A
QQ
K
GSEE
Q
RY
AI
AP
A--
F
T
WR
PDDK
T
NFT
----------
F
L
SYF
Q
N
E--
-
---
P
E
T
G
YY
G
W-
LP
KE
GT
VEPL
--
P
N
GK
-
-
-----RL
P
T
D
F
N
E
GAK
N
NTY
S
R
NEKMVGYS
F
D
H
E
FNDT
F
T
V
R
Q
N
L
R
F
A
E
N
K
T
S
Q
--
NS
V
YG
-
-
Y
GVCS
D
PANAY
S
KQ
--------
CAALAPADKGHYLA
R
KYVVD
D
EKL
Q
N
F
SV
D
T
Q
L
Q
S
K
F
A
TG
D
I
D
H
T
L
L
---------------
TGV
D
F
M
R
MR
N
DIN
A
W
--------------------
F
G
YD
DSV
P
LLD
-
LY
N
PVN
T
D
-
FDFNAKDPA
N
SG
P
YRIL----
N
KQK
QT
---G
V
Y
V
Q
D
QA
Q
WDKV
L
V
T
L
GG
-
-
--
-
-
--
RYD
W
A
D
Q
------------
ESLNRVAGT
T
D
-----
KRDD
K
QF
TW
R
G
G
VN
Y
-
L
F
DNG
V
T
P
Y
F
SY
S
E
SF
E
-----
P
---------
S
S
-QV
---
G
K
D
G
NI
-
FAP
S
KG
K
Q
YE
V
G
V
K
YVPE
D
R
PI
VV
T
G
A
V
YN
LTKT
N
NLM
--------
A
D
P
EG
S
F
FS
V
EG
G
EI
R
A
R
GVEIE
AK
---
A
A
LS
A
S
VN
V
V
G
S
YT
YTD
AE
YTTD
T
TY
K
GN
TP
AQ
--------
V
P
K
H
MAS
LW
A
D
Y
TFF
D
G
P
LS
G
LT
L
G
T
G
G
RY
T
G
--
S
S
Y---G
D
-
P
A
-
-
N
-S
F
KV
GSY
T
VVDA
LV
RY
D
L
A
R
VGMAG
S
N
V
A
L
H
VNNLFD
RE
YVAS
CFN
T
-
Y
-------
GCFW
GA
E
R
Q
V
VA
TAT
FR
F
fig|155864.1.peg.154
Escherichia coli O157:H7 EDL933
MAR
SKT
A
QPK
HSL
RKIAVV
V
A
T
AVS
G
MSVY
AQA
-
A
V
E
LK-
--
EDT
I
T
V
T
A
A
P
---
-
APQ
E
SA
WGPA
ATIAARQSAT
GTK
TDT
P
IQ
K
V
PQS
I
S
VV
T
A
E
E
M
A
LH
Q
PK
S
V
K
EAL
S
Y
TPGV
S
---
V
G
TR
G
A
S
N
T
Y
D
H
L
I
I
-
RGF
-
AAEG
Q
SQ
N
N
Y
L
N
G
L
KL
-------
Q
G
N
FYND
A
VI
D
PYML
ER
A
E
I
M
RGP
V
S
VL
YG
K
S
S
P
G
G
L
L
NMVSK
R
PT
T
EPL
K
-
E
V
QF
KA
G
T
DSLF
Q
TGF
D
FSDA
L
D
DDG
VY
S
Y
R
L
T
G
LA
RS
A
N
A
QQ
K
GSEE
Q
RY
AI
AP
A--
F
T
WR
PDDK
T
NFT
----------
F
L
SYF
Q
N
E--
-
---
P
E
T
G
YY
G
W-
LP
KE
GT
VEPL
--
P
N
GK
-
-
-----RL
P
T
D
F
N
E
GAK
N
NTY
S
R
NEKMVGYS
F
D
H
E
FNDT
F
T
V
R
Q
N
L
R
F
A
E
N
K
T
S
Q
--
NS
V
YG
-
-
Y
GVCS
D
PANAY
S
KQ
--------
CAALAPADKGHYLA
R
KYVVD
D
EKL
Q
N
F
SV
D
T
Q
L
Q
S
K
F
A
TG
D
I
D
H
T
L
L
---------------
TGV
D
F
M
R
MR
N
DIN
A
W
--------------------
F
G
YD
DSV
P
LLD
-
LY
N
PVN
T
D
-
FDFNAKDPA
N
SG
P
YRIL----
N
KQK
QT
---G
V
Y
V
Q
D
QA
Q
WDKV
L
V
T
L
GG
-
-
--
-
-
--
RYD
W
A
D
Q
------------
ESLNRVAGT
T
D
-----
KRDD
K
QF
TW
R
G
G
VN
Y
-
L
F
DNG
V
T
P
Y
F
SY
S
E
SF
E
-----
P
---------
S
S
-QV
---
G
K
D
G
NI
-
FAP
S
KG
K
Q
YE
V
G
V
K
YVPE
D
R
PI
VV
T
G
A
V
YN
LTKT
N
NLM
--------
A
D
P
EG
S
F
FS
V
EG
G
EI
R
A
R
GVEIE
AK
---
A
A
LS
A
S
VN
V
V
G
S
YT
YTD
AE
YTTD
T
TY
K
GN
TP
AQ
--------
V
P
K
H
MAS
LW
A
D
Y
TFF
D
G
P
LS
G
LT
L
G
T
G
G
RY
T
G
--
S
S
Y---G
D
-
P
A
-
-
N
-S
F
KV
GSY
T
VVDA
LV
RY
D
L
A
R
VGMAG
S
N
V
A
L
H
VNNLFD
RE
YVAS
CFN
T
-
Y
-------
GCFW
GA
E
R
Q
V
VA
TAT
FR
F
fig|155864.8.peg.155
Escherichia coli O157:H7 EDL933
MAR
SKT
A
QPK
HSL
RKIAVV
V
A
T
AVS
G
MSVY
AQA
-
A
V
E
LK-
--
EDT
I
T
V
T
A
A
P
---
-
APQ
E
SA
WGPA
ATIAARQSAT
GTK
TDT
P
IQ
K
V
PQS
I
S
VV
T
A
E
E
M
A
LH
Q
PK
S
V
K
EAL
S
Y
TPGV
S
---
V
G
TR
G
A
S
N
T
Y
D
H
L
I
I
-
RGF
-
AAEG
Q
SQ
N
N
Y
L
N
G
L
KL
-------
Q
G
N
FYND
A
VI
D
PYML
ER
A
E
I
M
RGP
V
S
VL
YG
K
S
S
P
G
G
L
L
NMVSK
R
PT
T
EPL
K
-
E
V
QF
KA
G
T
DSLF
Q
TGF
D
FSDA
L
D
DDG
VY
S
Y
R
L
T
G
LA
RS
A
N
A
QQ
K
GSEE
Q
RY
AI
AP
A--
F
T
WR
PDDK
T
NFT
----------
F
L
SYF
Q
N
E--
-
---
P
E
T
G
YY
G
W-
LP
KE
GT
VEPL
--
P
N
GK
-
-
-----RL
P
T
D
F
N
E
GAK
N
NTY
S
R
NEKMVGYS
F
D
H
E
FNDT
F
T
V
R
Q
N
L
R
F
A
E
N
K
T
S
Q
--
NS
V
YG
-
-
Y
GVCS
D
PANAY
S
KQ
--------
CAALAPADKGHYLA
R
KYVVD
D
EKL
Q
N
F
SV
D
T
Q
L
Q
S
K
F
A
TG
D
I
D
H
T
L
L
---------------
TGV
D
F
M
R
MR
N
DIN
A
W
--------------------
F
G
YD
DSV
P
LLD
-
LY
N
PVN
T
D
-
FDFNAKDPA
N
SG
P
YRIL----
N
KQK
QT
---G
V
Y
V
Q
D
QA
Q
WDKV
L
V
T
L
GG
-
-
--
-
-
--
RYD
W
A
D
Q
------------
ESLNRVAGT
T
D
-----
KRDD
K
QF
TW
R
G
G
VN
Y
-
L
F
DNG
V
T
P
Y
F
SY
S
E
SF
E
-----
P
---------
S
S
-QV
---
G
K
D
G
NI
-
FAP
S
KG
K
Q
YE
V
G
V
K
YVPE
D
R
PI
VV
T
G
A
V
YN
LTKT
N
NLM
--------
A
D
P
EG
S
F
FS
V
EG
G
EI
R
A
R
GVEIE
AK
---
A
A
LS
A
S
VN
V
V
G
S
YT
YTD
AE
YTTD
T
TY
K
GN
TP
AQ
--------
V
P
K
H
MAS
LW
A
D
Y
TFF
D
G
P
LS
G
LT
L
G
T
G
G
RY
T
G
--
S
S
Y---G
D
-
P
A
-
-
N
-S
F
KV
GSY
T
VVDA
LV
RY
D
L
A
R
VGMAG
S
N
V
A
L
H
VNNLFD
RE
YVAS
CFN
T
-
Y
-------
GCFW
GA
E
R
Q
V
VA
TAT
FR
F
fig|478006.5.peg.4657
Escherichia coli O157:H7 str. EC4501
MAR
SKT
A
QPK
HSL
RKIAVV
V
A
T
AVS
G
MSVY
AQA
-
A
V
E
LK-
--
EDT
I
T
V
T
A
A
P
---
-
APQ
E
SA
WGPA
ATIAARQSAT
GTK
TDT
P
IQ
K
V
PQS
I
S
VV
T
A
E
E
M
A
LH
Q
PK
S
V
K
EAL
S
Y
TPGV
S
---
V
G
TR
G
A
S
N
T
Y
D
H
L
I
I
-
RGF
-
AAEG
Q
SQ
N
N
Y
L
N
G
L
KL
-------
Q
G
N
FYND
A
VI
D
PYML
ER
A
E
I
M
RGP
V
S
VL
YG
K
S
S
P
G
G
L
L
NMVSK
R
PT
T
EPL
K
-
E
V
QF
KA
G
T
DSLF
Q
TGF
D
FSDA
L
D
DDG
VY
S
Y
R
L
T
G
LA
RS
A
N
A
QQ
K
GSEE
Q
RY
AI
AP
A--
F
T
WR
PDDK
T
NFT
----------
F
L
SYF
Q
N
E--
-
---
P
E
T
G
YY
G
W-
LP
KE
GT
VEPL
--
P
N
GK
-
-
-----RL
P
T
D
F
N
E
GAK
N
NTY
S
R
NEKMVGYS
F
D
H
E
FNDT
F
T
V
R
Q
N
L
R
F
A
E
N
K
T
S
Q
--
NS
V
YG
-
-
Y
GVCS
D
PANAY
S
KQ
--------
CAALAPADKGHYLA
R
KYVVD
D
EKL
Q
N
F
SV
D
T
Q
L
Q
S
K
F
A
TG
D
I
D
H
T
L
L
---------------
TGV
D
F
M
R
MR
N
DIN
A
W
--------------------
F
G
YD
DSV
P
LLD
-
LY
N
PVN
T
D
-
FDFNAKDPA
N
SG
P
YRIL----
N
KQK
QT
---G
V
Y
V
Q
D
QA
Q
WDKV
L
V
T
L
GG
-
-
--
-
-
--
RYD
W
A
D
Q
------------
ESLNRVAGT
T
D
-----
KRDD
K
QF
TW
R
G
G
VN
Y
-
L
F
DNG
V
T
P
Y
F
SY
S
E
SF
E
-----
P
---------
S
S
-QV
---
G
K
D
G
NI
-
FAP
S
KG
K
Q
YE
V
G
V
K
YVPE
D
R
PI
VV
T
G
A
V
YN
LTKT
N
NLM
--------
A
D
P
EG
S
F
FS
V
EG
G
EI
R
A
R
GVEIE
AK
---
A
A
LS
A
S
VN
V
V
G
S
YT
YTD
AE
YTTD
T
TY
K
GN
TP
AQ
--------
V
P
K
H
MAS
LW
A
D
Y
TFF
D
G
P
LS
G
LT
L
G
T
G
G
RY
T
G
--
S
S
Y---G
D
-
P
A
-
-
N
-S
F
KV
GSY
T
VVDA
LV
RY
D
L
A
R
VGMAG
S
N
V
A
L
H
VNNLFD
RE
YVAS
CFN
T
-
Y
-------
GCFW
GA
E
R
Q
V
VA
TAT
FR
F
fig|386585.9.peg.254
Escherichia coli O157:H7 str. Sakai
MAR
SKT
A
QPK
HSL
RKIAVV
V
A
T
AVS
G
MSVY
AQA
-
A
V
E
LK-
--
EDT
I
T
V
T
A
A
P
---
-
APQ
E
SA
WGPA
ATIAARQSAT
GTK
TDT
P
IQ
K
V
PQS
I
S
VV
T
A
E
E
M
A
LH
Q
PK
S
V
K
EAL
S
Y
TPGV
S
---
V
G
TR
G
A
S
N
T
Y
D
H
L
I
I
-
RGF
-
AAEG
Q
SQ
N
N
Y
L
N
G
L
KL
-------
Q
G
N
FYND
A
VI
D
PYML
ER
A
E
I
M
RGP
V
S
VL
YG
K
S
S
P
G
G
L
L
NMVSK
R
PT
T
EPL
K
-
E
V
QF
KA
G
T
DSLF
Q
TGF
D
FSDA
L
D
DDG
VY
S
Y
R
L
T
G
LA
RS
A
N
A
QQ
K
GSEE
Q
RY
AI
AP
A--
F
T
WR
PDDK
T
NFT
----------
F
L
SYF
Q
N
E--
-
---
P
E
T
G
YY
G
W-
LP
KE
GT
VEPL
--
P
N
GK
-
-
-----RL
P
T
D
F
N
E
GAK
N
NTY
S
R
NEKMVGYS
F
D
H
E
FNDT
F
T
V
R
Q
N
L
R
F
A
E
N
K
T
S
Q
--
NS
V
YG
-
-
Y
GVCS
D
PANAY
S
KQ
--------
CAALAPADKGHYLA
R
KYVVD
D
EKL
Q
N
F
SV
D
T
Q
L
Q
S
K
F
A
TG
D
I
D
H
T
L
L
---------------
TGV
D
F
M
R
MR
N
DIN
A
W
--------------------
F
G
YD
DSV
P
LLD
-
LY
N
PVN
T
D
-
FDFNAKDPA
N
SG
P
YRIL----
N
KQK
QT
---G
V
Y
V
Q
D
QA
Q
WDKV
L
V
T
L
GG
-
-
--
-
-
--
RYD
W
A
D
Q
------------
ESLNRVAGT
T
D
-----
KRDD
K
QF
TW
R
G
G
VN
Y
-
L
F
DNG
V
T
P
Y
F
SY
S
E
SF
E
-----
P
---------
S
S
-QV
---
G
K
D
G
NI
-
FAP
S
KG
K
Q
YE
V
G
V
K
YVPE
D
R
PI
VV
T
G
A
V
YN
LTKT
N
NLM
--------
A
D
P
EG
S
F
FS
V
EG
G
EI
R
A
R
GVEIE
AK
---
A
A
LS
A
S
VN
V
V
G
S
YT
YTD
AE
YTTD
T
TY
K
GN
TP
AQ
--------
V
P
K
H
MAS
LW
A
D
Y
TFF
D
G
P
LS
G
LT
L
G
T
G
G
RY
T
G
--
S
S
Y---G
D
-
P
A
-
-
N
-S
F
KV
GSY
T
VVDA
LV
RY
D
L
A
R
VGMAG
S
N
V
A
L
H
VNNLFD
RE
YVAS
CFN
T
-
Y
-------
GCFW
GA
E
R
Q
V
VA
TAT
FR
F
fig|502346.5.peg.1109
Escherichia coli O157:H7 str. TW14588
MAR
SKT
A
QPK
HSL
RKIAVV
V
A
T
AVS
G
MSVY
AQA
-
A
V
E
LK-
--
EDT
I
T
V
T
A
A
P
---
-
APQ
E
SA
WGPA
ATIAARQSAT
GTK
TDT
P
IQ
K
V
PQS
I
S
VV
T
A
E
E
M
A
LH
Q
PK
S
V
K
EAL
S
Y
TPGV
S
---
V
G
TR
G
A
S
N
T
Y
D
H
L
I
I
-
RGF
-
AAEG
Q
SQ
N
N
Y
L
N
G
L
KL
-------
Q
G
N
FYND
A
VI
D
PYML
ER
A
E
I
M
RGP
V
S
VL
YG
K
S
S
P
G
G
L
L
NMVSK
R
PT
T
EPL
K
-
E
V
QF
KA
G
T
DSLF
Q
TGF
D
FSDA
L
D
DDG
VY
S
Y
R
L
T
G
LA
RS
A
N
A
QQ
K
GSEE
Q
RY
AI
AP
A--
F
T
WR
PDDK
T
NFT
----------
F
L
SYF
Q
N
E--
-
---
P
E
T
G
YY
G
W-
LP
KE
GT
VEPL
--
P
N
GK
-
-
-----RL
P
T
D
F
N
E
GAK
N
NTY
S
R
NEKMVGYS
F
D
H
E
FNDT
F
T
V
R
Q
N
L
R
F
A
E
N
K
T
S
Q
--
NS
V
YG
-
-
Y
GVCS
D
PANAY
S
KQ
--------
CAALAPADKGHYLA
R
KYVVD
D
EKL
Q
N
F
SV
D
T
Q
L
Q
S
K
F
A
TG
D
I
D
H
T
L
L
---------------
TGV
D
F
M
R
MR
N
DIN
A
W
--------------------
F
G
YD
DSV
P
LLD
-
LY
N
PVN
T
D
-
FDFNAKDPA
N
SG
P
YRIL----
N
KQK
QT
---G
V
Y
V
Q
D
QA
Q
WDKV
L
V
T
L
GG
-
-
--
-
-
--
RYD
W
A
D
Q
------------
ESLNRVAGT
T
D
-----
KRDD
K
QF
TW
R
G
G
VN
Y
-
L
F
DNG
V
T
P
Y
F
SY
S
E
SF
E
-----
P
---------
S
S
-QV
---
G
K
D
G
NI
-
FAP
S
KG
K
Q
YE
V
G
V
K
YVPE
D
R
PI
VV
T
G
A
V
YN
LTKT
N
NLM
--------
A
D
P
EG
S
F
FS
V
EG
G
EI
R
A
R
GVEIE
AK
---
A
A
LS
A
S
VN
V
V
G
S
YT
YTD
AE
YTTD
T
TY
K
GN
TP
AQ
--------
V
P
K
H
MAS
LW
A
D
Y
TFF
D
G
P
LS
G
LT
L
G
T
G
G
RY
T
G
--
S
S
Y---G
D
-
P
A
-
-
N
-S
F
KV
GSY
T
VVDA
LV
RY
D
L
A
R
VGMAG
S
N
V
A
L
H
VNNLFD
RE
YVAS
CFN
T
-
Y
-------
GCFW
GA
E
R
Q
V
VA
TAT
FR
F
fig|362663.8.peg.163
Escherichia coli 536
MA
PSKT
A
QPK
HSL
RKIAVV
V
A
T
AVS
G
MSVY
AQA
-
A
V
E
PK-
--
EDT
I
T
V
T
A
A
P
---
-
APQ
E
SA
WGPA
ATIAARQSAT
GTK
TDT
P
IQ
K
V
PQS
I
S
VV
T
A
E
E
M
A
LH
Q
PK
S
V
K
EAL
S
Y
TPGV
S
---
V
G
TR
G
A
S
N
T
Y
D
H
L
I
I
-
RGF
-
AAEG
Q
SQ
N
N
Y
L
N
G
L
KL
-------
Q
G
N
FYND
A
VI
D
PYML
ER
A
E
I
M
RGP
V
S
VL
YG
K
S
S
P
G
G
L
L
NMVSK
R
PT
T
EPL
K
-
E
V
QF
KA
G
T
DSLF
Q
TGF
D
FSDA
L
D
DDG
VY
S
Y
R
L
T
G
LA
RS
A
N
A
QQ
K
GSEE
Q
RY
AI
AP
A--
F
T
WR
PDDK
T
NFT
----------
F
L
SYF
Q
N
E--
-
---
P
E
T
G
YY
G
W-
LP
KE
GT
VEPL
--
P
N
GK
-
-
-----RL
P
T
D
F
N
E
GAK
N
NTY
S
R
NEKMVGYS
F
D
H
E
FNDT
F
T
V
R
Q
N
L
R
F
A
E
N
K
T
S
Q
--
NS
V
YG
-
-
Y
GVCS
D
PANAY
S
KQ
--------
CAALAPADKGHYLA
R
KYVVD
D
EKL
Q
N
F
SV
D
T
Q
L
Q
S
K
F
A
TG
D
I
D
H
T
L
L
---------------
TGV
D
F
M
R
MR
N
DIN
A
W
--------------------
F
G
YD
DSV
P
LLD
-
LY
N
PVN
T
D
-
FDFNAKDPD
N
SG
P
YRIL----
N
KQK
QT
---G
V
Y
V
Q
D
QA
Q
WDKV
L
V
T
L
GG
-
-
--
-
-
--
RYD
W
A
D
Q
------------
ESLNRVAGT
T
D
-----
KRDD
K
QF
TW
R
G
G
VN
Y
-
L
F
DNG
V
T
P
Y
F
SY
S
E
SF
E
-----
P
---------
S
S
-QV
---
G
K
D
G
NI
-
FAP
S
KG
K
Q
YE
V
G
V
K
YVPE
D
R
PI
VV
T
G
A
V
YN
LTKT
N
NLM
--------
A
D
P
EG
S
F
FS
V
EG
G
EI
R
A
R
GVEIE
AK
---
A
A
LS
A
S
VN
V
V
G
S
YT
YTD
AE
YTTD
T
TY
K
GN
TP
AQ
--------
V
P
K
H
MAS
LW
A
D
Y
TFF
D
G
P
LS
G
LT
L
G
T
G
G
RY
T
G
--
S
S
Y---G
D
-
P
A
-
-
N
-S
F
KV
GSY
T
VVDA
LV
RY
D
L
A
R
VGMAG
S
N
V
A
L
H
VNNLFD
RE
YVAS
CFN
T
-
Y
-------
GCFW
GA
E
R
Q
V
VA
TAT
FR
F
fig|362663.9.peg.163
Escherichia coli 536
MA
PSKT
A
QPK
HSL
RKIAVV
V
A
T
AVS
G
MSVY
AQA
-
A
V
E
PK-
--
EDT
I
T
V
T
A
A
P
---
-
APQ
E
SA
WGPA
ATIAARQSAT
GTK
TDT
P
IQ
K
V
PQS
I
S
VV
T
A
E
E
M
A
LH
Q
PK
S
V
K
EAL
S
Y
TPGV
S
---
V
G
TR
G
A
S
N
T
Y
D
H
L
I
I
-
RGF
-
AAEG
Q
SQ
N
N
Y
L
N
G
L
KL
-------
Q
G
N
FYND
A
VI
D
PYML
ER
A
E
I
M
RGP
V
S
VL
YG
K
S
S
P
G
G
L
L
NMVSK
R
PT
T
EPL
K
-
E
V
QF
KA
G
T
DSLF
Q
TGF
D
FSDA
L
D
DDG
VY
S
Y
R
L
T
G
LA
RS
A
N
A
QQ
K
GSEE
Q
RY
AI
AP
A--
F
T
WR
PDDK
T
NFT
----------
F
L
SYF
Q
N
E--
-
---
P
E
T
G
YY
G
W-
LP
KE
GT
VEPL
--
P
N
GK
-
-
-----RL
P
T
D
F
N
E
GAK
N
NTY
S
R
NEKMVGYS
F
D
H
E
FNDT
F
T
V
R
Q
N
L
R
F
A
E
N
K
T
S
Q
--
NS
V
YG
-
-
Y
GVCS
D
PANAY
S
KQ
--------
CAALAPADKGHYLA
R
KYVVD
D
EKL
Q
N
F
SV
D
T
Q
L
Q
S
K
F
A
TG
D
I
D
H
T
L
L
---------------
TGV
D
F
M
R
MR
N
DIN
A
W
--------------------
F
G
YD
DSV
P
LLD
-
LY
N
PVN
T
D
-
FDFNAKDPD
N
SG
P
YRIL----
N
KQK
QT
---G
V
Y
V
Q
D
QA
Q
WDKV
L
V
T
L
GG
-
-
--
-
-
--
RYD
W
A
D
Q
------------
ESLNRVAGT
T
D
-----
KRDD
K
QF
TW
R
G
G
VN
Y
-
L
F
DNG
V
T
P
Y
F
SY
S
E
SF
E
-----
P
---------
S
S
-QV
---
G
K
D
G
NI
-
FAP
S
KG
K
Q
YE
V
G
V
K
YVPE
D
R
PI
VV
T
G
A
V
YN
LTKT
N
NLM
--------
A
D
P
EG
S
F
FS
V
EG
G
EI
R
A
R
GVEIE
AK
---
A
A
LS
A
S
VN
V
V
G
S
YT
YTD
AE
YTTD
T
TY
K
GN
TP
AQ
--------
V
P
K
H
MAS
LW
A
D
Y
TFF
D
G
P
LS
G
LT
L
G
T
G
G
RY
T
G
--
S
S
Y---G
D
-
P
A
-
-
N
-S
F
KV
GSY
T
VVDA
LV
RY
D
L
A
R
VGMAG
S
N
V
A
L
H
VNNLFD
RE
YVAS
CFN
T
-
Y
-------
GCFW
GA
E
R
Q
V
VA
TAT
FR
F
fig|405955.13.peg.163
Escherichia coli APEC O1
MA
PSKT
A
QPK
HSL
RKIAVV
V
A
T
AVS
G
MSVY
AQA
-
A
V
E
PK-
--
EDT
I
T
V
T
A
A
P
---
-
APQ
E
SA
WGPA
ATIAARQSAT
GTK
TDT
P
IQ
K
V
PQS
I
S
VV
T
A
E
E
M
A
LH
Q
PK
S
V
K
EAL
S
Y
TPGV
S
---
V
G
TR
G
A
S
N
T
Y
D
H
L
I
I
-
RGF
-
AAEG
Q
SQ
N
N
Y
L
N
G
L
KL
-------
Q
G
N
FYND
A
VI
D
PYML
ER
A
E
I
M
RGP
V
S
VL
YG
K
S
S
P
G
G
L
L
NMVSK
R
PT
T
EPL
K
-
E
V
QF
KA
G
T
DSLF
Q
TGF
D
FSDA
L
D
DDG
VY
S
Y
R
L
T
G
LA
RS
A
N
A
QQ
K
GSEE
Q
RY
AI
AP
A--
F
T
WR
PDDK
T
NFT
----------
F
L
SYF
Q
N
E--
-
---
P
E
T
G
YY
G
W-
LP
KE
GT
VEPL
--
P
N
GK
-
-
-----RL
P
T
D
F
N
E
GAK
N
NTY
S
R
NEKMVGYS
F
D
H
E
FNDT
F
T
V
R
Q
N
L
R
F
A
E
N
K
T
S
Q
--
NS
V
YG
-
-
Y
GVCS
D
PANAY
S
KQ
--------
CAALAPADKGHYLA
R
KYVVD
D
EKL
Q
N
F
SV
D
T
Q
L
Q
S
K
F
A
TG
D
I
D
H
T
L
L
---------------
TGV
D
F
M
R
MR
N
DIN
A
W
--------------------
F
G
YD
DSV
P
LLD
-
LY
N
PVN
T
D
-
FDFNAKDPD
N
SG
P
YRIL----
N
KQK
QT
---G
V
Y
V
Q
D
QA
Q
WDKV
L
V
T
L
GG
-
-
--
-
-
--
RYD
W
A
D
Q
------------
ESLNRVAGT
T
D
-----
KRDD
K
QF
TW
R
G
G
VN
Y
-
L
F
DNG
V
T
P
Y
F
SY
S
E
SF
E
-----
P
---------
S
S
-QV
---
G
K
D
G
NI
-
FAP
S
KG
K
Q
YE
V
G
V
K
YVPE
D
R
PI
VV
T
G
A
V
YN
LTKT
N
NLM
--------
A
D
P
EG
S
F
FS
V
EG
G
EI
R
A
R
GVEIE
AK
---
A
A
LS
A
S
VN
V
V
G
S
YT
YTD
AE
YTTD
T
TY
K
GN
TP
AQ
--------
V
P
K
H
MAS
LW
A
D
Y
TFF
D
G
P
LS
G
LT
L
G
T
G
G
RY
T
G
--
S
S
Y---G
D
-
P
A
-
-
N
-S
F
KV
GSY
T
VVDA
LV
RY
D
L
A
R
VGMAG
S
N
V
A
L
H
VNNLFD
RE
YVAS
CFN
T
-
Y
-------
GCFW
GA
E
R
Q
V
VA
TAT
FR
F
fig|405955.9.peg.131
Escherichia coli APEC O1
MA
PSKT
A
QPK
HSL
RKIAVV
V
A
T
AVS
G
MSVY
AQA
-
A
V
E
PK-
--
EDT
I
T
V
T
A
A
P
---
-
APQ
E
SA
WGPA
ATIAARQSAT
GTK
TDT
P
IQ
K
V
PQS
I
S
VV
T
A
E
E
M
A
LH
Q
PK
S
V
K
EAL
S
Y
TPGV
S
---
V
G
TR
G
A
S
N
T
Y
D
H
L
I
I
-
RGF
-
AAEG
Q
SQ
N
N
Y
L
N
G
L
KL
-------
Q
G
N
FYND
A
VI
D
PYML
ER
A
E
I
M
RGP
V
S
VL
YG
K
S
S
P
G
G
L
L
NMVSK
R
PT
T
EPL
K
-
E
V
QF
KA
G
T
DSLF
Q
TGF
D
FSDA
L
D
DDG
VY
S
Y
R
L
T
G
LA
RS
A
N
A
QQ
K
GSEE
Q
RY
AI
AP
A--
F
T
WR
PDDK
T
NFT
----------
F
L
SYF
Q
N
E--
-
---
P
E
T
G
YY
G
W-
LP
KE
GT
VEPL
--
P
N
GK
-
-
-----RL
P
T
D
F
N
E
GAK
N
NTY
S
R
NEKMVGYS
F
D
H
E
FNDT
F
T
V
R
Q
N
L
R
F
A
E
N
K
T
S
Q
--
NS
V
YG
-
-
Y
GVCS
D
PANAY
S
KQ
--------
CAALAPADKGHYLA
R
KYVVD
D
EKL
Q
N
F
SV
D
T
Q
L
Q
S
K
F
A
TG
D
I
D
H
T
L
L
---------------
TGV
D
F
M
R
MR
N
DIN
A
W
--------------------
F
G
YD
DSV
P
LLD
-
LY
N
PVN
T
D
-
FDFNAKDPD
N
SG
P
YRIL----
N
KQK
QT
---G
V
Y
V
Q
D
QA
Q
WDKV
L
V
T
L
GG
-
-
--
-
-
--
RYD
W
A
D
Q
------------
ESLNRVAGT
T
D
-----
KRDD
K
QF
TW
R
G
G
VN
Y
-
L
F
DNG
V
T
P
Y
F
SY
S
E
SF
E
-----
P
---------
S
S
-QV
---
G
K
D
G
NI
-
FAP
S
KG
K
Q
YE
V
G
V
K
YVPE
D
R
PI
VV
T
G
A
V
YN
LTKT
N
NLM
--------
A
D
P
EG
S
F
FS
V
EG
G
EI
R
A
R
GVEIE
AK
---
A
A
LS
A
S
VN
V
V
G
S
YT
YTD
AE
YTTD
T
TY
K
GN
TP
AQ
--------
V
P
K
H
MAS
LW
A
D
Y
TFF
D
G
P
LS
G
LT
L
G
T
G
G
RY
T
G
--
S
S
Y---G
D
-
P
A
-
-
N
-S
F
KV
GSY
T
VVDA
LV
RY
D
L
A
R
VGMAG
S
N
V
A
L
H
VNNLFD
RE
YVAS
CFN
T
-
Y
-------
GCFW
GA
E
R
Q
V
VA
TAT
FR
F
fig|340197.3.peg.2903
Escherichia coli F11
MA
PSKT
A
QPK
HSL
RKIAVV
V
A
T
AVS
G
MSVY
AQA
-
A
V
E
PK-
--
EDT
I
T
V
T
A
A
P
---
-
APQ
E
SA
WGPA
ATIAARQSAT
GTK
TDT
P
IQ
K
V
PQS
I
S
VV
T
A
E
E
M
A
LH
Q
PK
S
V
K
EAL
S
Y
TPGV
S
---
V
G
TR
G
A
S
N
T
Y
D
H
L
I
I
-
RGF
-
AAEG
Q
SQ
N
N
Y
L
N
G
L
KL
-------
Q
G
N
FYND
A
VI
D
PYML
ER
A
E
I
M
RGP
V
S
VL
YG
K
S
S
P
G
G
L
L
NMVSK
R
PT
T
EPL
K
-
E
V
QF
KA
G
T
DSLF
Q
TGF
D
FSDA
L
D
DDG
VY
S
Y
R
L
T
G
LA
RS
A
N
A
QQ
K
GSEE
Q
RY
AI
AP
A--
F
T
WR
PDDK
T
NFT
----------
F
L
SYF
Q
N
E--
-
---
P
E
T
G
YY
G
W-
LP
KE
GT
VEPL
--
P
N
GK
-
-
-----RL
P
T
D
F
N
E
GAK
N
NTY
S
R
NEKMVGYS
F
D
H
E
FNDT
F
T
V
R
Q
N
L
R
F
A
E
N
K
T
S
Q
--
NS
V
YG
-
-
Y
GVCS
D
PANAY
S
KQ
--------
CAALAPADKGHYLA
R
KYVVD
D
EKL
Q
N
F
SV
D
T
Q
L
Q
S
K
F
A
TG
D
I
D
H
T
L
L
---------------
TGV
D
F
M
R
MR
N
DIN
A
W
--------------------
F
G
YD
DSV
P
LLD
-
LY
N
PVN
T
D
-
FDFNAKDPD
N
SG
P
YRIL----
N
KQK
QT
---G
V
Y
V
Q
D
QA
Q
WDKV
L
V
T
L
GG
-
-
--
-
-
--
RYD
W
A
D
Q
------------
ESLNRVAGT
T
D
-----
KRDD
K
QF
TW
R
G
G
VN
Y
-
L
F
DNG
V
T
P
Y
F
SY
S
E
SF
E
-----
P
---------
S
S
-QV
---
G
K
D
G
NI
-
FAP
S
KG
K
Q
YE
V
G
V
K
YVPE
D
R
PI
VV
T
G
A
V
YN
LTKT
N
NLM
--------
A
D
P
EG
S
F
FS
V
EG
G
EI
R
A
R
GVEIE
AK
---
A
A
LS
A
S
VN
V
V
G
S
YT
YTD
AE
YTTD
T
TY
K
GN
TP
AQ
--------
V
P
K
H
MAS
LW
A
D
Y
TFF
D
G
P
LS
G
LT
L
G
T
G
G
RY
T
G
--
S
S
Y---G
D
-
P
A
-
-
N
-S
F
KV
GSY
T
VVDA
LV
RY
D
L
A
R
VGMAG
S
N
V
A
L
H
VNNLFD
RE
YVAS
CFN
T
-
Y
-------
GCFW
GA
E
R
Q
V
VA
TAT
FR
F
fig|340197.5.peg.3034
Escherichia coli F11
MA
PSKT
A
QPK
HSL
RKIAVV
V
A
T
AVS
G
MSVY
AQA
-
A
V
E
PK-
--
EDT
I
T
V
T
A
A
P
---
-
APQ
E
SA
WGPA
ATIAARQSAT
GTK
TDT
P
IQ
K
V
PQS
I
S
VV
T
A
E
E
M
A
LH
Q
PK
S
V
K
EAL
S
Y
TPGV
S
---
V
G
TR
G
A
S
N
T
Y
D
H
L
I
I
-
RGF
-
AAEG
Q
SQ
N
N
Y
L
N
G
L
KL
-------
Q
G
N
FYND
A
VI
D
PYML
ER
A
E
I
M
RGP
V
S
VL
YG
K
S
S
P
G
G
L
L
NMVSK
R
PT
T
EPL
K
-
E
V
QF
KA
G
T
DSLF
Q
TGF
D
FSDA
L
D
DDG
VY
S
Y
R
L
T
G
LA
RS
A
N
A
QQ
K
GSEE
Q
RY
AI
AP
A--
F
T
WR
PDDK
T
NFT
----------
F
L
SYF
Q
N
E--
-
---
P
E
T
G
YY
G
W-
LP
KE
GT
VEPL
--
P
N
GK
-
-
-----RL
P
T
D
F
N
E
GAK
N
NTY
S
R
NEKMVGYS
F
D
H
E
FNDT
F
T
V
R
Q
N
L
R
F
A
E
N
K
T
S
Q
--
NS
V
YG
-
-
Y
GVCS
D
PANAY
S
KQ
--------
CAALAPADKGHYLA
R
KYVVD
D
EKL
Q
N
F
SV
D
T
Q
L
Q
S
K
F
A
TG
D
I
D
H
T
L
L
---------------
TGV
D
F
M
R
MR
N
DIN
A
W
--------------------
F
G
YD
DSV
P
LLD
-
LY
N
PVN
T
D
-
FDFNAKDPD
N
SG
P
YRIL----
N
KQK
QT
---G
V
Y
V
Q
D
QA
Q
WDKV
L
V
T
L
GG
-
-
--
-
-
--
RYD
W
A
D
Q
------------
ESLNRVAGT
T
D
-----
KRDD
K
QF
TW
R
G
G
VN
Y
-
L
F
DNG
V
T
P
Y
F
SY
S
E
SF
E
-----
P
---------
S
S
-QV
---
G
K
D
G
NI
-
FAP
S
KG
K
Q
YE
V
G
V
K
YVPE
D
R
PI
VV
T
G
A
V
YN
LTKT
N
NLM
--------
A
D
P
EG
S
F
FS
V
EG
G
EI
R
A
R
GVEIE
AK
---
A
A
LS
A
S
VN
V
V
G
S
YT
YTD
AE
YTTD
T
TY
K
GN
TP
AQ
--------
V
P
K
H
MAS
LW
A
D
Y
TFF
D
G
P
LS
G
LT
L
G
T
G
G
RY
T
G
--
S
S
Y---G
D
-
P
A
-
-
N
-S
F
KV
GSY
T
VVDA
LV
RY
D
L
A
R
VGMAG
S
N
V
A
L
H
VNNLFD
RE
YVAS
CFN
T
-
Y
-------
GCFW
GA
E
R
Q
V
VA
TAT
FR
F
fig|714962.3.peg.160
Escherichia coli IHE3034
MA
PSKT
A
QPK
HSL
RKIAVV
V
A
T
AVS
G
MSVY
AQA
-
A
V
E
PK-
--
EDT
I
T
V
T
A
A
P
---
-
APQ
E
SA
WGPA
ATIAARQSAT
GTK
TDT
P
IQ
K
V
PQS
I
S
VV
T
A
E
E
M
A
LH
Q
PK
S
V
K
EAL
S
Y
TPGV
S
---
V
G
TR
G
A
S
N
T
Y
D
H
L
I
I
-
RGF
-
AAEG
Q
SQ
N
N
Y
L
N
G
L
KL
-------
Q
G
N
FYND
A
VI
D
PYML
ER
A
E
I
M
RGP
V
S
VL
YG
K
S
S
P
G
G
L
L
NMVSK
R
PT
T
EPL
K
-
E
V
QF
KA
G
T
DSLF
Q
TGF
D
FSDA
L
D
DDG
VY
S
Y
R
L
T
G
LA
RS
A
N
A
QQ
K
GSEE
Q
RY
AI
AP
A--
F
T
WR
PDDK
T
NFT
----------
F
L
SYF
Q
N
E--
-
---
P
E
T
G
YY
G
W-
LP
KE
GT
VEPL
--
P
N
GK
-
-
-----RL
P
T
D
F
N
E
GAK
N
NTY
S
R
NEKMVGYS
F
D
H
E
FNDT
F
T
V
R
Q
N
L
R
F
A
E
N
K
T
S
Q
--
NS
V
YG
-
-
Y
GVCS
D
PANAY
S
KQ
--------
CAALAPADKGHYLA
R
KYVVD
D
EKL
Q
N
F
SV
D
T
Q
L
Q
S
K
F
A
TG
D
I
D
H
T
L
L
---------------
TGV
D
F
M
R
MR
N
DIN
A
W
--------------------
F
G
YD
DSV
P
LLD
-
LY
N
PVN
T
D
-
FDFNAKDPD
N
SG
P
YRIL----
N
KQK
QT
---G
V
Y
V
Q
D
QA
Q
WDKV
L
V
T
L
GG
-
-
--
-
-
--
RYD
W
A
D
Q
------------
ESLNRVAGT
T
D
-----
KRDD
K
QF
TW
R
G
G
VN
Y
-
L
F
DNG
V
T
P
Y
F
SY
S
E
SF
E
-----
P
---------
S
S
-QV
---
G
K
D
G
NI
-
FAP
S
KG
K
Q
YE
V
G
V
K
YVPE
D
R
PI
VV
T
G
A
V
YN
LTKT
N
NLM
--------
A
D
P
EG
S
F
FS
V
EG
G
EI
R
A
R
GVEIE
AK
---
A
A
LS
A
S
VN
V
V
G
S
YT
YTD
AE
YTTD
T
TY
K
GN
TP
AQ
--------
V
P
K
H
MAS
LW
A
D
Y
TFF
D
G
P
LS
G
LT
L
G
T
G
G
RY
T
G
--
S
S
Y---G
D
-
P
A
-
-
N
-S
F
KV
GSY
T
VVDA
LV
RY
D
L
A
R
VGMAG
S
N
V
A
L
H
VNNLFD
RE
YVAS
CFN
T
-
Y
-------
GCFW
GA
E
R
Q
V
VA
TAT
FR
F
fig|749550.3.peg.2479
Escherichia coli MS 200-1
MA
PSKT
A
QPK
HSL
RKIAVV
V
A
T
AVS
G
MSVY
AQA
-
A
V
E
PK-
--
EDT
I
T
V
T
A
A
P
---
-
APQ
E
SA
WGPA
ATIAARQSAT
GTK
TDT
P
IQ
K
V
PQS
I
S
VV
T
A
E
E
M
A
LH
Q
PK
S
V
K
EAL
S
Y
TPGV
S
---
V
G
TR
G
A
S
N
T
Y
D
H
L
I
I
-
RGF
-
AAEG
Q
SQ
N
N
Y
L
N
G
L
KL
-------
Q
G
N
FYND
A
VI
D
PYML
ER
A
E
I
M
RGP
V
S
VL
YG
K
S
S
P
G
G
L
L
NMVSK
R
PT
T
EPL
K
-
E
V
QF
KA
G
T
DSLF
Q
TGF
D
FSDA
L
D
DDG
VY
S
Y
R
L
T
G
LA
RS
A
N
A
QQ
K
GSEE
Q
RY
AI
AP
A--
F
T
WR
PDDK
T
NFT
----------
F
L
SYF
Q
N
E--
-
---
P
E
T
G
YY
G
W-
LP
KE
GT
VEPL
--
P
N
GK
-
-
-----RL
P
T
D
F
N
E
GAK
N
NTY
S
R
NEKMVGYS
F
D
H
E
FNDT
F
T
V
R
Q
N
L
R
F
A
E
N
K
T
S
Q
--
NS
V
YG
-
-
Y
GVCS
D
PANAY
S
KQ
--------
CAALAPADKGHYLA
R
KYVVD
D
EKL
Q
N
F
SV
D
T
Q
L
Q
S
K
F
A
TG
D
I
D
H
T
L
L
---------------
TGV
D
F
M
R
MR
N
DIN
A
W
--------------------
F
G
YD
DSV
P
LLD
-
LY
N
PVN
T
D
-
FDFNAKDPD
N
SG
P
YRIL----
N
KQK
QT
---G
V
Y
V
Q
D
QA
Q
WDKV
L
V
T
L
GG
-
-
--
-
-
--
RYD
W
A
D
Q
------------
ESLNRVAGT
T
D
-----
KRDD
K
QF
TW
R
G
G
VN
Y
-
L
F
DNG
V
T
P
Y
F
SY
S
E
SF
E
-----
P
---------
S
S
-QV
---
G
K
D
G
NI
-
FAP
S
KG
K
Q
YE
V
G
V
K
YVPE
D
R
PI
VV
T
G
A
V
YN
LTKT
N
NLM
--------
A
D
P
EG
S
F
FS
V
EG
G
EI
R
A
R
GVEIE
AK
---
A
A
LS
A
S
VN
V
V
G
S
YT
YTD
AE
YTTD
T
TY
K
GN
TP
AQ
--------
V
P
K
H
MAS
LW
A
D
Y
TFF
D
G
P
LS
G
LT
L
G
T
G
G
RY
T
G
--
S
S
Y---G
D
-
P
A
-
-
N
-S
F
KV
GSY
T
VVDA
LV
RY
D
L
A
R
VGMAG
S
N
V
A
L
H
VNNLFD
RE
YVAS
CFN
T
-
Y
-------
GCFW
GA
E
R
Q
V
VA
TAT
FR
F
fig|685038.3.peg.157
Escherichia coli O83:H1 str. NRG 857C
MA
PSKT
A
QPK
HSL
RKIAVV
V
A
T
AVS
G
MSVY
AQA
-
A
V
E
PK-
--
EDT
I
T
V
T
A
A
P
---
-
APQ
E
SA
WGPA
ATIAARQSAT
GTK
TDT
P
IQ
K
V
PQS
I
S
VV
T
A
E
E
M
A
LH
Q
PK
S
V
K
EAL
S
Y
TPGV
S
---
V
G
TR
G
A
S
N
T
Y
D
H
L
I
I
-
RGF
-
AAEG
Q
SQ
N
N
Y
L
N
G
L
KL
-------
Q
G
N
FYND
A
VI
D
PYML
ER
A
E
I
M
RGP
V
S
VL
YG
K
S
S
P
G
G
L
L
NMVSK
R
PT
T
EPL
K
-
E
V
QF
KA
G
T
DSLF
Q
TGF
D
FSDA
L
D
DDG
VY
S
Y
R
L
T
G
LA
RS
A
N
A
QQ
K
GSEE
Q
RY
AI
AP
A--
F
T
WR
PDDK
T
NFT
----------
F
L
SYF
Q
N
E--
-
---
P
E
T
G
YY
G
W-
LP
KE
GT
VEPL
--
P
N
GK
-
-
-----RL
P
T
D
F
N
E
GAK
N
NTY
S
R
NEKMVGYS
F
D
H
E
FNDT
F
T
V
R
Q
N
L
R
F
A
E
N
K
T
S
Q
--
NS
V
YG
-
-
Y
GVCS
D
PANAY
S
KQ
--------
CAALAPADKGHYLA
R
KYVVD
D
EKL
Q
N
F
SV
D
T
Q
L
Q
S
K
F
A
TG
D
I
D
H
T
L
L
---------------
TGV
D
F
M
R
MR
N
DIN
A
W
--------------------
F
G
YD
DSV
P
LLD
-
LY
N
PVN
T
D
-
FDFNAKDPD
N
SG
P
YRIL----
N
KQK
QT
---G
V
Y
V
Q
D
QA
Q
WDKV
L
V
T
L
GG
-
-
--
-
-
--
RYD
W
A
D
Q
------------
ESLNRVAGT
T
D
-----
KRDD
K
QF
TW
R
G
G
VN
Y
-
L
F
DNG
V
T
P
Y
F
SY
S
E
SF
E
-----
P
---------
S
S
-QV
---
G
K
D
G
NI
-
FAP
S
KG
K
Q
YE
V
G
V
K
YVPE
D
R
PI
VV
T
G
A
V
YN
LTKT
N
NLM
--------
A
D
P
EG
S
F
FS
V
EG
G
EI
R
A
R
GVEIE
AK
---
A
A
LS
A
S
VN
V
V
G
S
YT
YTD
AE
YTTD
T
TY
K
GN
TP
AQ
--------
V
P
K
H
MAS
LW
A
D
Y
TFF
D
G
P
LS
G
LT
L
G
T
G
G
RY
T
G
--
S
S
Y---G
D
-
P
A
-
-
N
-S
F
KV
GSY
T
VVDA
LV
RY
D
L
A
R
VGMAG
S
N
V
A
L
H
VNNLFD
RE
YVAS
CFN
T
-
Y
-------
GCFW
GA
E
R
Q
V
VA
TAT
FR
F
fig|585035.6.peg.164
Escherichia coli S88
MA
PSKT
A
QPK
HSL
RKIAVV
V
A
T
AVS
G
MSVY
AQA
-
A
V
E
PK-
--
EDT
I
T
V
T
A
A
P
---
-
APQ
E
SA
WGPA
ATIAARQSAT
GTK
TDT
P
IQ
K
V
PQS
I
S
VV
T
A
E
E
M
A
LH
Q
PK
S
V
K
EAL
S
Y
TPGV
S
---
V
G
TR
G
A
S
N
T
Y
D
H
L
I
I
-
RGF
-
AAEG
Q
SQ
N
N
Y
L
N
G
L
KL
-------
Q
G
N
FYND
A
VI
D
PYML
ER
A
E
I
M
RGP
V
S
VL
YG
K
S
S
P
G
G
L
L
NMVSK
R
PT
T
EPL
K
-
E
V
QF
KA
G
T
DSLF
Q
TGF
D
FSDA
L
D
DDG
VY
S
Y
R
L
T
G
LA
RS
A
N
A
QQ
K
GSEE
Q
RY
AI
AP
A--
F
T
WR
PDDK
T
NFT
----------
F
L
SYF
Q
N
E--
-
---
P
E
T
G
YY
G
W-
LP
KE
GT
VEPL
--
P
N
GK
-
-
-----RL
P
T
D
F
N
E
GAK
N
NTY
S
R
NEKMVGYS
F
D
H
E
FNDT
F
T
V
R
Q
N
L
R
F
A
E
N
K
T
S
Q
--
NS
V
YG
-
-
Y
GVCS
D
PANAY
S
KQ
--------
CAALAPADKGHYLA
R
KYVVD
D
EKL
Q
N
F
SV
D
T
Q
L
Q
S
K
F
A
TG
D
I
D
H
T
L
L
---------------
TGV
D
F
M
R
MR
N
DIN
A
W
--------------------
F
G
YD
DSV
P
LLD
-
LY
N
PVN
T
D
-
FDFNAKDPD
N
SG
P
YRIL----
N
KQK
QT
---G
V
Y
V
Q
D
QA
Q
WDKV
L
V
T
L
GG
-
-
--
-
-
--
RYD
W
A
D
Q
------------
ESLNRVAGT
T
D
-----
KRDD
K
QF
TW
R
G
G
VN
Y
-
L
F
DNG
V
T
P
Y
F
SY
S
E
SF
E
-----
P
---------
S
S
-QV
---
G
K
D
G
NI
-
FAP
S
KG
K
Q
YE
V
G
V
K
YVPE
D
R
PI
VV
T
G
A
V
YN
LTKT
N
NLM
--------
A
D
P
EG
S
F
FS
V
EG
G
EI
R
A
R
GVEIE
AK
---
A
A
LS
A
S
VN
V
V
G
S
YT
YTD
AE
YTTD
T
TY
K
GN
TP
AQ
--------
V
P
K
H
MAS
LW
A
D
Y
TFF
D
G
P
LS
G
LT
L
G
T
G
G
RY
T
G
--
S
S
Y---G
D
-
P
A
-
-
N
-S
F
KV
GSY
T
VVDA
LV
RY
D
L
A
R
VGMAG
S
N
V
A
L
H
VNNLFD
RE
YVAS
CFN
T
-
Y
-------
GCFW
GA
E
R
Q
V
VA
TAT
FR
F
fig|869729.3.peg.5068
Escherichia coli UM146
MA
PSKT
A
QPK
HSL
RKIAVV
V
A
T
AVS
G
MSVY
AQA
-
A
V
E
PK-
--
EDT
I
T
V
T
A
A
P
---
-
APQ
E
SA
WGPA
ATIAARQSAT
GTK
TDT
P
IQ
K
V
PQS
I
S
VV
T
A
E
E
M
A
LH
Q
PK
S
V
K
EAL
S
Y
TPGV
S
---
V
G
TR
G
A
S
N
T
Y
D
H
L
I
I
-
RGF
-
AAEG
Q
SQ
N
N
Y
L
N
G
L
KL
-------
Q
G
N
FYND
A
VI
D
PYML
ER
A
E
I
M
RGP
V
S
VL
YG
K
S
S
P
G
G
L
L
NMVSK
R
PT
T
EPL
K
-
E
V
QF
KA
G
T
DSLF
Q
TGF
D
FSDA
L
D
DDG
VY
S
Y
R
L
T
G
LA
RS
A
N
A
QQ
K
GSEE
Q
RY
AI
AP
A--
F
T
WR
PDDK
T
NFT
----------
F
L
SYF
Q
N
E--
-
---
P
E
T
G
YY
G
W-
LP
KE
GT
VEPL
--
P
N
GK
-
-
-----RL
P
T
D
F
N
E
GAK
N
NTY
S
R
NEKMVGYS
F
D
H
E
FNDT
F
T
V
R
Q
N
L
R
F
A
E
N
K
T
S
Q
--
NS
V
YG
-
-
Y
GVCS
D
PANAY
S
KQ
--------
CAALAPADKGHYLA
R
KYVVD
D
EKL
Q
N
F
SV
D
T
Q
L
Q
S
K
F
A
TG
D
I
D
H
T
L
L
---------------
TGV
D
F
M
R
MR
N
DIN
A
W
--------------------
F
G
YD
DSV
P
LLD
-
LY
N
PVN
T
D
-
FDFNAKDPD
N
SG
P
YRIL----
N
KQK
QT
---G
V
Y
V
Q
D
QA
Q
WDKV
L
V
T
L
GG
-
-
--
-
-
--
RYD
W
A
D
Q
------------
ESLNRVAGT
T
D
-----
KRDD
K
QF
TW
R
G
G
VN
Y
-
L
F
DNG
V
T
P
Y
F
SY
S
E
SF
E
-----
P
---------
S
S
-QV
---
G
K
D
G
NI
-
FAP
S
KG
K
Q
YE
V
G
V
K
YVPE
D
R
PI
VV
T
G
A
V
YN
LTKT
N
NLM
--------
A
D
P
EG
S
F
FS
V
EG
G
EI
R
A
R
GVEIE
AK
---
A
A
LS
A
S
VN
V
V
G
S
YT
YTD
AE
YTTD
T
TY
K
GN
TP
AQ
--------
V
P
K
H
MAS
LW
A
D
Y
TFF
D
G
P
LS
G
LT
L
G
T
G
G
RY
T
G
--
S
S
Y---G
D
-
P
A
-
-
N
-S
F
KV
GSY
T
VVDA
LV
RY
D
L
A
R
VGMAG
S
N
V
A
L
H
VNNLFD
RE
YVAS
CFN
T
-
Y
-------
GCFW
GA
E
R
Q
V
VA
TAT
FR
F
fig|364106.8.peg.293
Escherichia coli UTI89
MA
PSKT
A
QPK
HSL
RKIAVV
V
A
T
AVS
G
MSVY
AQA
-
A
V
E
PK-
--
EDT
I
T
V
T
A
A
P
---
-
APQ
E
SA
WGPA
ATIAARQSAT
GTK
TDT
P
IQ
K
V
PQS
I
S
VV
T
A
E
E
M
A
LH
Q
PK
S
V
K
EAL
S
Y
TPGV
S
---
V
G
TR
G
A
S
N
T
Y
D
H
L
I
I
-
RGF
-
AAEG
Q
SQ
N
N
Y
L
N
G
L
KL
-------
Q
G
N
FYND
A
VI
D
PYML
ER
A
E
I
M
RGP
V
S
VL
YG
K
S
S
P
G
G
L
L
NMVSK
R
PT
T
EPL
K
-
E
V
QF
KA
G
T
DSLF
Q
TGF
D
FSDA
L
D
DDG
VY
S
Y
R
L
T
G
LA
RS
A
N
A
QQ
K
GSEE
Q
RY
AI
AP
A--
F
T
WR
PDDK
T
NFT
----------
F
L
SYF
Q
N
E--
-
---
P
E
T
G
YY
G
W-
LP
KE
GT
VEPL
--
P
N
GK
-
-
-----RL
P
T
D
F
N
E
GAK
N
NTY
S
R
NEKMVGYS
F
D
H
E
FNDT
F
T
V
R
Q
N
L
R
F
A
E
N
K
T
S
Q
--
NS
V
YG
-
-
Y
GVCS
D
PANAY
S
KQ
--------
CAALAPADKGHYLA
R
KYVVD
D
EKL
Q
N
F
SV
D
T
Q
L
Q
S
K
F
A
TG
D
I
D
H
T
L
L
---------------
TGV
D
F
M
R
MR
N
DIN
A
W
--------------------
F
G
YD
DSV
P
LLD
-
LY
N
PVN
T
D
-
FDFNAKDPD
N
SG
P
YRIL----
N
KQK
QT
---G
V
Y
V
Q
D
QA
Q
WDKV
L
V
T
L
GG
-
-
--
-
-
--
RYD
W
A
D
Q
------------
ESLNRVAGT
T
D
-----
KRDD
K
QF
TW
R
G
G
VN
Y
-
L
F
DNG
V
T
P
Y
F
SY
S
E
SF
E
-----
P
---------
S
S
-QV
---
G
K
D
G
NI
-
FAP
S
KG
K
Q
YE
V
G
V
K
YVPE
D
R
PI
VV
T
G
A
V
YN
LTKT
N
NLM
--------
A
D
P
EG
S
F
FS
V
EG
G
EI
R
A
R
GVEIE
AK
---
A
A
LS
A
S
VN
V
V
G
S
YT
YTD
AE
YTTD
T
TY
K
GN
TP
AQ
--------
V
P
K
H
MAS
LW
A
D
Y
TFF
D
G
P
LS
G
LT
L
G
T
G
G
RY
T
G
--
S
S
Y---G
D
-
P
A
-
-
N
-S
F
KV
GSY
T
VVDA
LV
RY
D
L
A
R
VGMAG
S
N
V
A
L
H
VNNLFD
RE
YVAS
CFN
T
-
Y
-------
GCFW
GA
E
R
Q
V
VA
TAT
FR
F
fig|562.376.peg.1148
Escherichia coli WV_060327
MA
PSKT
A
QPK
HSL
RKIAVV
V
A
T
AVS
G
MSVY
AQA
-
A
V
E
PK-
--
EDT
I
T
V
T
A
A
P
---
-
APQ
E
SA
WGPA
ATIAARQSAT
GTK
TDT
P
IQ
K
V
PQS
I
S
VV
T
A
E
E
M
A
LH
Q
PK
S
V
K
EAL
S
Y
TPGV
S
---
V
G
TR
G
A
S
N
T
Y
D
H
L
I
I
-
RGF
-
AAEG
Q
SQ
N
N
Y
L
N
G
L
KL
-------
Q
G
N
FYND
A
VI
D
PYML
ER
A
E
I
M
RGP
V
S
VL
YG
K
S
S
P
G
G
L
L
NMVSK
R
PT
T
EPL
K
-
E
V
QF
KA
G
T
DSLF
Q
TGF
D
FSDA
L
D
DDG
VY
S
Y
R
L
T
G
LA
RS
A
N
A
QQ
K
GSEE
Q
RY
AI
AP
A--
F
T
WR
PDDK
T
NFT
----------
F
L
SYF
Q
N
E--
-
---
P
E
T
G
YY
G
W-
LP
KE
GT
VEPL
--
P
N
GK
-
-
-----RL
P
T
D
F
N
E
GAK
N
NTY
S
R
NEKMVGYS
F
D
H
E
FNDT
F
T
V
R
Q
N
L
R
F
A
E
N
K
T
S
Q
--
NS
V
YG
-
-
Y
GVCS
D
PANAY
S
KQ
--------
CAALAPADKGHYLA
R
KYVVD
D
EKL
Q
N
F
SV
D
T
Q
L
Q
S
K
F
A
TG
D
I
D
H
T
L
L
---------------
TGV
D
F
M
R
MR
N
DIN
A
W
--------------------
F
G
YD
DSV
P
LLD
-
LY
N
PVN
T
D
-
FDFNAKDPD
N
SG
P
YRIL----
N
KQK
QT
---G
V
Y
V
Q
D
QA
Q
WDKV
L
V
T
L
GG
-
-
--
-
-
--
RYD
W
A
D
Q
------------
ESLNRVAGT
T
D
-----
KRDD
K
QF
TW
R
G
G
VN
Y
-
L
F
DNG
V
T
P
Y
F
SY
S
E
SF
E
-----
P
---------
S
S
-QV
---
G
K
D
G
NI
-
FAP
S
KG
K
Q
YE
V
G
V
K
YVPE
D
R
PI
VV
T
G
A
V
YN
LTKT
N
NLM
--------
A
D
P
EG
S
F
FS
V
EG
G
EI
R
A
R
GVEIE
AK
---
A
A
LS
A
S
VN
V
V
G
S
YT
YTD
AE
YTTD
T
TY
K
GN
TP
AQ
--------
V
P
K
H
MAS
LW
A
D
Y
TFF
D
G
P
LS
G
LT
L
G
T
G
G
RY
T
G
--
S
S
Y---G
D
-
P
A
-
-
N
-S
F
KV
GSY
T
VVDA
LV
RY
D
L
A
R
VGMAG
S
N
V
A
L
H
VNNLFD
RE
YVAS
CFN
T
-
Y
-------
GCFW
GA
E
R
Q
V
VA
TAT
FR
F
fig|1040638.4.peg.5717
Escherichia coli O104:H4 str. LB226692
MAR
SKT
A
QPK
HSL
RKIAVV
V
A
T
AVS
G
MSVY
AQA
-
A
V
E
PK-
--
EDT
I
T
V
T
A
A
P
---
-
APQ
E
SA
WGPA
ATIAARQSAT
GTK
TDT
P
IQ
K
V
PQS
I
S
VV
T
A
E
E
M
A
LH
Q
PK
S
V
K
EAL
S
Y
TPGV
S
---
V
G
TR
G
A
S
N
T
Y
D
H
L
I
I
-
RGF
-
AAEG
Q
SQ
N
N
Y
L
N
G
L
KL
-------
Q
G
N
FYND
A
VI
D
PYML
ER
A
E
I
M
RGP
V
S
VL
YG
K
S
S
P
G
G
L
L
NMVSK
R
PT
T
EPL
K
-
E
V
QF
KA
G
T
DSLF
Q
TGF
D
FSDS
L
D
DDG
VY
S
Y
R
L
T
G
LA
RS
A
N
A
QQ
K
GSEE
Q
RY
AI
AP
A--
F
T
WR
PDDK
T
NFT
----------
F
L
SYF
Q
N
E--
-
---
P
E
T
G
YY
G
W-
LP
KE
GT
VEPL
--
P
N
GK
-
-
-----RL
P
T
D
F
N
E
GAK
N
NTY
S
R
NEKMVGYS
F
D
H
E
FNDT
F
T
V
R
Q
N
L
R
F
A
E
N
K
T
S
Q
--
NS
V
YG
-
-
Y
GVCS
D
PANAY
S
KQ
--------
CAALAPADKGHYLA
R
KYVVD
D
EKL
Q
N
F
SV
D
T
Q
L
Q
S
K
F
A
TG
D
I
D
H
T
L
L
---------------
TGV
D
F
M
R
MR
N
DIN
A
W
--------------------
F
G
YD
DSV
P
LLN
-
LY
N
PVN
T
D
-
FDFNAKDPA
N
SG
P
YRIL----
N
KQK
QT
---G
V
Y
V
Q
D
QA
Q
WDKV
L
V
T
L
GG
-
-
--
-
-
--
RYD
W
A
D
Q
------------
ESLNRVAGT
T
D
-----
KRDD
K
QF
TW
R
G
G
VN
Y
-
L
F
DNG
V
T
P
Y
F
SY
S
E
SF
E
-----
P
---------
S
S
-QV
---
G
K
D
G
NI
-
FAP
S
KG
K
Q
YE
V
G
V
K
YVPE
D
R
PI
VV
T
G
A
V
YN
LTKT
N
NLM
--------
A
D
P
EG
S
F
FS
V
EG
G
EI
R
A
R
GVEIE
AK
---
A
A
LS
A
S
VN
V
V
G
S
YT
YTD
AE
YTTD
T
TY
K
GN
TP
AQ
--------
V
P
K
H
MAS
LW
A
D
Y
TFF
D
G
P
LS
G
LT
L
G
T
G
G
RY
T
G
--
S
S
Y---G
D
-
P
A
-
-
N
-S
F
KV
GSY
T
VVDA
LV
RY
D
L
A
R
VGMAG
S
N
V
A
L
H
VNNLFD
RE
YVAS
CFN
T
-
Y
-------
GCFW
GA
E
R
Q
V
VA
TAT
FR
F
fig|6666666.5357.peg.2081
Escherichia coli TY-2482
MAR
SKT
A
QPK
HSL
RKIAVV
V
A
T
AVS
G
MSVY
AQA
-
A
V
E
PK-
--
EDT
I
T
V
T
A
A
P
---
-
APQ
E
SA
WGPA
ATIAARQSAT
GTK
TDT
P
IQ
K
V
PQS
I
S
VV
T
A
E
E
M
A
LH
Q
PK
S
V
K
EAL
S
Y
TPGV
S
---
V
G
TR
G
A
S
N
T
Y
D
H
L
I
I
-
RGF
-
AAEG
Q
SQ
N
N
Y
L
N
G
L
KL
-------
Q
G
N
FYND
A
VI
D
PYML
ER
A
E
I
M
RGP
V
S
VL
YG
K
S
S
P
G
G
L
L
NMVSK
R
PT
T
EPL
K
-
E
V
QF
KA
G
T
DSLF
Q
TGF
D
FSDS
L
D
DDG
VY
S
Y
R
L
T
G
LA
RS
A
N
A
QQ
K
GSEE
Q
RY
AI
AP
A--
F
T
WR
PDDK
T
NFT
----------
F
L
SYF
Q
N
E--
-
---
P
E
T
G
YY
G
W-
LP
KE
GT
VEPL
--
P
N
GK
-
-
-----RL
P
T
D
F
N
E
GAK
N
NTY
S
R
NEKMVGYS
F
D
H
E
FNDT
F
T
V
R
Q
N
L
R
F
A
E
N
K
T
S
Q
--
NS
V
YG
-
-
Y
GVCS
D
PANAY
S
KQ
--------
CAALAPADKGHYLA
R
KYVVD
D
EKL
Q
N
F
SV
D
T
Q
L
Q
S
K
F
A
TG
D
I
D
H
T
L
L
---------------
TGV
D
F
M
R
MR
N
DIN
A
W
--------------------
F
G
YD
DSV
P
LLN
-
LY
N
PVN
T
D
-
FDFNAKDPA
N
SG
P
YRIL----
N
KQK
QT
---G
V
Y
V
Q
D
QA
Q
WDKV
L
V
T
L
GG
-
-
--
-
-
--
RYD
W
A
D
Q
------------
ESLNRVAGT
T
D
-----
KRDD
K
QF
TW
R
G
G
VN
Y
-
L
F
DNG
V
T
P
Y
F
SY
S
E
SF
E
-----
P
---------
S
S
-QV
---
G
K
D
G
NI
-
FAP
S
KG
K
Q
YE
V
G
V
K
YVPE
D
R
PI
VV
T
G
A
V
YN
LTKT
N
NLM
--------
A
D
P
EG
S
F
FS
V
EG
G
EI
R
A
R
GVEIE
AK
---
A
A
LS
A
S
VN
V
V
G
S
YT
YTD
AE
YTTD
T
TY
K
GN
TP
AQ
--------
V
P
K
H
MAS
LW
A
D
Y
TFF
D
G
P
LS
G
LT
L
G
T
G
G
RY
T
G
--
S
S
Y---G
D
-
P
A
-
-
N
-S
F
KV
GSY
T
VVDA
LV
RY
D
L
A
R
VGMAG
S
N
V
A
L
H
VNNLFD
RE
YVAS
CFN
T
-
Y
-------
GCFW
GA
E
R
Q
V
VA
TAT
FR
F
fig|550672.3.peg.4422
Escherichia coli B088
MAR
SKT
A
QPK
HSL
RKIAVV
V
A
T
AVS
G
MSVY
AQA
-
A
V
E
PK-
--
EDT
I
T
V
T
A
A
P
---
-
APQ
E
SA
WGPA
ATIAARQSAT
GTK
TDT
P
IQ
K
V
PQS
I
S
VV
T
A
E
E
M
A
LH
Q
PK
S
V
K
EAL
S
Y
TPGV
S
---
V
G
TR
G
A
S
N
T
Y
D
H
L
I
I
-
RGF
-
AAEG
Q
SQ
N
N
Y
L
N
G
L
KL
-------
Q
G
N
FYND
A
VI
D
PYML
ER
A
E
I
M
RGP
V
S
VL
YG
K
S
S
P
G
G
L
L
NMVSK
R
PT
T
EPL
K
-
E
V
QF
KA
G
T
DSLF
Q
TGF
D
FSDS
L
D
DDG
VY
S
Y
R
L
T
G
LA
RS
A
N
A
QQ
K
GSEE
Q
RY
AI
AP
A--
F
T
WR
PDDK
T
NFT
----------
F
L
SYF
Q
N
E--
-
---
P
E
T
G
YY
G
W-
LP
KE
GT
VEPL
--
P
N
GK
-
-
-----RL
P
T
D
F
N
E
GAK
N
NTY
S
R
NEKMVGYS
F
D
H
E
FNDT
F
T
V
R
Q
N
L
R
F
A
E
N
K
T
S
Q
--
NS
V
YG
-
-
Y
GVCS
D
PANAY
S
KQ
--------
CAALAPADKGHYLA
R
KYVVD
D
EKL
Q
N
F
SV
D
T
Q
L
Q
S
K
F
A
TG
D
I
D
H
T
L
L
---------------
TGV
D
F
M
R
MR
N
DIN
A
W
--------------------
F
G
YD
DSV
P
LLN
-
LY
N
PVN
T
D
-
FDFNAKDPA
N
SG
P
YRIL----
N
KQK
QT
---G
V
Y
V
Q
D
QA
Q
WDKV
L
V
T
L
GG
-
-
--
-
-
--
RYD
W
A
D
Q
------------
ESLNRVAGT
T
D
-----
KRDD
K
QF
TW
R
G
G
VN
Y
-
L
F
DNG
V
T
P
Y
F
SY
S
E
SF
E
-----
P
---------
S
S
-QV
---
G
K
D
G
NI
-
FAP
S
KG
K
Q
YE
V
G
V
K
YVPE
D
R
PI
VV
T
G
A
V
YN
LTKT
N
NLM
--------
A
D
P
EG
S
F
FS
V
EG
G
EI
R
A
R
GVEIE
AK
---
A
A
LS
A
S
VN
V
V
G
S
YT
YTD
AE
YTTD
T
TY
K
GN
TP
AQ
--------
V
P
K
H
MAS
LW
A
D
Y
TFF
D
G
P
LS
G
LT
L
G
T
G
G
RY
T
G
--
S
S
Y---G
D
-
P
A
-
-
N
-S
F
KV
GSY
T
VVDA
LV
RY
D
L
A
R
VGMAG
S
N
V
A
L
H
VNNLFD
RE
YVAS
CFN
T
-
Y
-------
GCFW
GA
E
R
Q
V
VA
TAT
FR
F
fig|344601.3.peg.2602
Escherichia coli B171
MAR
SKT
A
QPK
HSL
RKIAVV
V
A
T
AVS
G
MSVY
AQA
-
A
V
E
PK-
--
EDT
I
T
V
T
A
A
P
---
-
APQ
E
SA
WGPA
ATIAARQSAT
GTK
TDT
P
IQ
K
V
PQS
I
S
VV
T
A
E
E
M
A
LH
Q
PK
S
V
K
EAL
S
Y
TPGV
S
---
V
G
TR
G
A
S
N
T
Y
D
H
L
I
I
-
RGF
-
AAEG
Q
SQ
N
N
Y
L
N
G
L
KL
-------
Q
G
N
FYND
A
VI
D
PYML
ER
A
E
I
M
RGP
V
S
VL
YG
K
S
S
P
G
G
L
L
NMVSK
R
PT
T
EPL
K
-
E
V
QF
KA
G
T
DSLF
Q
TGF
D
FSDS
L
D
DDG
VY
S
Y
R
L
T
G
LA
RS
A
N
A
QQ
K
GSEE
Q
RY
AI
AP
A--
F
T
WR
PDDK
T
NFT
----------
F
L
SYF
Q
N
E--
-
---
P
E
T
G
YY
G
W-
LP
KE
GT
VEPL
--
P
N
GK
-
-
-----RL
P
T
D
F
N
E
GAK
N
NTY
S
R
NEKMVGYS
F
D
H
E
FNDT
F
T
V
R
Q
N
L
R
F
A
E
N
K
T
S
Q
--
NS
V
YG
-
-
Y
GVCS
D
PANAY
S
KQ
--------
CAALAPADKGHYLA
R
KYVVD
D
EKL
Q
N
F
SV
D
T
Q
L
Q
S
K
F
A
TG
D
I
D
H
T
L
L
---------------
TGV
D
F
M
R
MR
N
DIN
A
W
--------------------
F
G
YD
DSV
P
LLN
-
LY
N
PVN
T
D
-
FDFNAKDPA
N
SG
P
YRIL----
N
KQK
QT
---G
V
Y
V
Q
D
QA
Q
WDKV
L
V
T
L
GG
-
-
--
-
-
--
RYD
W
A
D
Q
------------
ESLNRVAGT
T
D
-----
KRDD
K
QF
TW
R
G
G
VN
Y
-
L
F
DNG
V
T
P
Y
F
SY
S
E
SF
E
-----
P
---------
S
S
-QV
---
G
K
D
G
NI
-
FAP
S
KG
K
Q
YE
V
G
V
K
YVPE
D
R
PI
VV
T
G
A
V
YN
LTKT
N
NLM
--------
A
D
P
EG
S
F
FS
V
EG
G
EI
R
A
R
GVEIE
AK
---
A
A
LS
A
S
VN
V
V
G
S
YT
YTD
AE
YTTD
T
TY
K
GN
TP
AQ
--------
V
P
K
H
MAS
LW
A
D
Y
TFF
D
G
P
LS
G
LT
L
G
T
G
G
RY
T
G
--
S
S
Y---G
D
-
P
A
-
-
N
-S
F
KV
GSY
T
VVDA
LV
RY
D
L
A
R
VGMAG
S
N
V
A
L
H
VNNLFD
RE
YVAS
CFN
T
-
Y
-------
GCFW
GA
E
R
Q
V
VA
TAT
FR
F
fig|340184.3.peg.1401
Escherichia coli B7A
MAR
SKT
A
QPK
HSL
RKIAVV
V
A
T
AVS
G
MSVY
AQA
-
A
V
E
PK-
--
EDT
I
T
V
T
A
A
P
---
-
APQ
E
SA
WGPA
ATIAARQSAT
GTK
TDT
P
IQ
K
V
PQS
I
S
VV
T
A
E
E
M
A
LH
Q
PK
S
V
K
EAL
S
Y
TPGV
S
---
V
G
TR
G
A
S
N
T
Y
D
H
L
I
I
-
RGF
-
AAEG
Q
SQ
N
N
Y
L
N
G
L
KL
-------
Q
G
N
FYND
A
VI
D
PYML
ER
A
E
I
M
RGP
V
S
VL
YG
K
S
S
P
G
G
L
L
NMVSK
R
PT
T
EPL
K
-
E
V
QF
KA
G
T
DSLF
Q
TGF
D
FSDS
L
D
DDG
VY
S
Y
R
L
T
G
LA
RS
A
N
A
QQ
K
GSEE
Q
RY
AI
AP
A--
F
T
WR
PDDK
T
NFT
----------
F
L
SYF
Q
N
E--
-
---
P
E
T
G
YY
G
W-
LP
KE
GT
VEPL
--
P
N
GK
-
-
-----RL
P
T
D
F
N
E
GAK
N
NTY
S
R
NEKMVGYS
F
D
H
E
FNDT
F
T
V
R
Q
N
L
R
F
A
E
N
K
T
S
Q
--
NS
V
YG
-
-
Y
GVCS
D
PANAY
S
KQ
--------
CAALAPADKGHYLA
R
KYVVD
D
EKL
Q
N
F
SV
D
T
Q
L
Q
S
K
F
A
TG
D
I
D
H
T
L
L
---------------
TGV
D
F
M
R
MR
N
DIN
A
W
--------------------
F
G
YD
DSV
P
LLN
-
LY
N
PVN
T
D
-
FDFNAKDPA
N
SG
P
YRIL----
N
KQK
QT
---G
V
Y
V
Q
D
QA
Q
WDKV
L
V
T
L
GG
-
-
--
-
-
--
RYD
W
A
D
Q
------------
ESLNRVAGT
T
D
-----
KRDD
K
QF
TW
R
G
G
VN
Y
-
L
F
DNG
V
T
P
Y
F
SY
S
E
SF
E
-----
P
---------
S
S
-QV
---
G
K
D
G
NI
-
FAP
S
KG
K
Q
YE
V
G
V
K
YVPE
D
R
PI
VV
T
G
A
V
YN
LTKT
N
NLM
--------
A
D
P
EG
S
F
FS
V
EG
G
EI
R
A
R
GVEIE
AK
---
A
A
LS
A
S
VN
V
V
G
S
YT
YTD
AE
YTTD
T
TY
K
GN
TP
AQ
--------
V
P
K
H
MAS
LW
A
D
Y
TFF
D
G
P
LS
G
LT
L
G
T
G
G
RY
T
G
--
S
S
Y---G
D
-
P
A
-
-
N
-S
F
KV
GSY
T
VVDA
LV
RY
D
L
A
R
VGMAG
S
N
V
A
L
H
VNNLFD
RE
YVAS
CFN
T
-
Y
-------
GCFW
GA
E
R
Q
V
VA
TAT
FR
F
fig|340184.6.peg.1479
Escherichia coli B7A
MAR
SKT
A
QPK
HSL
RKIAVV
V
A
T
AVS
G
MSVY
AQA
-
A
V
E
PK-
--
EDT
I
T
V
T
A
A
P
---
-
APQ
E
SA
WGPA
ATIAARQSAT
GTK
TDT
P
IQ
K
V
PQS
I
S
VV
T
A
E
E
M
A
LH
Q
PK
S
V
K
EAL
S
Y
TPGV
S
---
V
G
TR
G
A
S
N
T
Y
D
H
L
I
I
-
RGF
-
AAEG
Q
SQ
N
N
Y
L
N
G
L
KL
-------
Q
G
N
FYND
A
VI
D
PYML
ER
A
E
I
M
RGP
V
S
VL
YG
K
S
S
P
G
G
L
L
NMVSK
R
PT
T
EPL
K
-
E
V
QF
KA
G
T
DSLF
Q
TGF
D
FSDS
L
D
DDG
VY
S
Y
R
L
T
G
LA
RS
A
N
A
QQ
K
GSEE
Q
RY
AI
AP
A--
F
T
WR
PDDK
T
NFT
----------
F
L
SYF
Q
N
E--
-
---
P
E
T
G
YY
G
W-
LP
KE
GT
VEPL
--
P
N
GK
-
-
-----RL
P
T
D
F
N
E
GAK
N
NTY
S
R
NEKMVGYS
F
D
H
E
FNDT
F
T
V
R
Q
N
L
R
F
A
E
N
K
T
S
Q
--
NS
V
YG
-
-
Y
GVCS
D
PANAY
S
KQ
--------
CAALAPADKGHYLA
R
KYVVD
D
EKL
Q
N
F
SV
D
T
Q
L
Q
S
K
F
A
TG
D
I
D
H
T
L
L
---------------
TGV
D
F
M
R
MR
N
DIN
A
W
--------------------
F
G
YD
DSV
P
LLN
-
LY
N
PVN
T
D
-
FDFNAKDPA
N
SG
P
YRIL----
N
KQK
QT
---G
V
Y
V
Q
D
QA
Q
WDKV
L
V
T
L
GG
-
-
--
-
-
--
RYD
W
A
D
Q
------------
ESLNRVAGT
T
D
-----
KRDD
K
QF
TW
R
G
G
VN
Y
-
L
F
DNG
V
T
P
Y
F
SY
S
E
SF
E
-----
P
---------
S
S
-QV
---
G
K
D
G
NI
-
FAP
S
KG
K
Q
YE
V
G
V
K
YVPE
D
R
PI
VV
T
G
A
V
YN
LTKT
N
NLM
--------
A
D
P
EG
S
F
FS
V
EG
G
EI
R
A
R
GVEIE
AK
---
A
A
LS
A
S
VN
V
V
G
S
YT
YTD
AE
YTTD
T
TY
K
GN
TP
AQ
--------
V
P
K
H
MAS
LW
A
D
Y
TFF
D
G
P
LS
G
LT
L
G
T
G
G
RY
T
G
--
S
S
Y---G
D
-
P
A
-
-
N
-S
F
KV
GSY
T
VVDA
LV
RY
D
L
A
R
VGMAG
S
N
V
A
L
H
VNNLFD
RE
YVAS
CFN
T
-
Y
-------
GCFW
GA
E
R
Q
V
VA
TAT
FR
F
fig|595496.3.peg.156
Escherichia coli BW2952
MAR
SKT
A
QPK
HSL
RKIAVV
V
A
T
AVS
G
MSVY
AQA
-
A
V
E
PK-
--
EDT
I
T
V
T
A
A
P
---
-
APQ
E
SA
WGPA
ATIAARQSAT
GTK
TDT
P
IQ
K
V
PQS
I
S
VV
T
A
E
E
M
A
LH
Q
PK
S
V
K
EAL
S
Y
TPGV
S
---
V
G
TR
G
A
S
N
T
Y
D
H
L
I
I
-
RGF
-
AAEG
Q
SQ
N
N
Y
L
N
G
L
KL
-------
Q
G
N
FYND
A
VI
D
PYML
ER
A
E
I
M
RGP
V
S
VL
YG
K
S
S
P
G
G
L
L
NMVSK
R
PT
T
EPL
K
-
E
V
QF
KA
G
T
DSLF
Q
TGF
D
FSDS
L
D
DDG
VY
S
Y
R
L
T
G
LA
RS
A
N
A
QQ
K
GSEE
Q
RY
AI
AP
A--
F
T
WR
PDDK
T
NFT
----------
F
L
SYF
Q
N
E--
-
---
P
E
T
G
YY
G
W-
LP
KE
GT
VEPL
--
P
N
GK
-
-
-----RL
P
T
D
F
N
E
GAK
N
NTY
S
R
NEKMVGYS
F
D
H
E
FNDT
F
T
V
R
Q
N
L
R
F
A
E
N
K
T
S
Q
--
NS
V
YG
-
-
Y
GVCS
D
PANAY
S
KQ
--------
CAALAPADKGHYLA
R
KYVVD
D
EKL
Q
N
F
SV
D
T
Q
L
Q
S
K
F
A
TG
D
I
D
H
T
L
L
---------------
TGV
D
F
M
R
MR
N
DIN
A
W
--------------------
F
G
YD
DSV
P
LLN
-
LY
N
PVN
T
D
-
FDFNAKDPA
N
SG
P
YRIL----
N
KQK
QT
---G
V
Y
V
Q
D
QA
Q
WDKV
L
V
T
L
GG
-
-
--
-
-
--
RYD
W
A
D
Q
------------
ESLNRVAGT
T
D
-----
KRDD
K
QF
TW
R
G
G
VN
Y
-
L
F
DNG
V
T
P
Y
F
SY
S
E
SF
E
-----
P
---------
S
S
-QV
---
G
K
D
G
NI
-
FAP
S
KG
K
Q
YE
V
G
V
K
YVPE
D
R
PI
VV
T
G
A
V
YN
LTKT
N
NLM
--------
A
D
P
EG
S
F
FS
V
EG
G
EI
R
A
R
GVEIE
AK
---
A
A
LS
A
S
VN
V
V
G
S
YT
YTD
AE
YTTD
T
TY
K
GN
TP
AQ
--------
V
P
K
H
MAS
LW
A
D
Y
TFF
D
G
P
LS
G
LT
L
G
T
G
G
RY
T
G
--
S
S
Y---G
D
-
P
A
-
-
N
-S
F
KV
GSY
T
VVDA
LV
RY
D
L
A
R
VGMAG
S
N
V
A
L
H
VNNLFD
RE
YVAS
CFN
T
-
Y
-------
GCFW
GA
E
R
Q
V
VA
TAT
FR
F
fig|536056.3.peg.3647
Escherichia coli DH1
MAR
SKT
A
QPK
HSL
RKIAVV
V
A
T
AVS
G
MSVY
AQA
-
A
V
E
PK-
--
EDT
I
T
V
T
A
A
P
---
-
APQ
E
SA
WGPA
ATIAARQSAT
GTK
TDT
P
IQ
K
V
PQS
I
S
VV
T
A
E
E
M
A
LH
Q
PK
S
V
K
EAL
S
Y
TPGV
S
---
V
G
TR
G
A
S
N
T
Y
D
H
L
I
I
-
RGF
-
AAEG
Q
SQ
N
N
Y
L
N
G
L
KL
-------
Q
G
N
FYND
A
VI
D
PYML
ER
A
E
I
M
RGP
V
S
VL
YG
K
S
S
P
G
G
L
L
NMVSK
R
PT
T
EPL
K
-
E
V
QF
KA
G
T
DSLF
Q
TGF
D
FSDS
L
D
DDG
VY
S
Y
R
L
T
G
LA
RS
A
N
A
QQ
K
GSEE
Q
RY
AI
AP
A--
F
T
WR
PDDK
T
NFT
----------
F
L
SYF
Q
N
E--
-
---
P
E
T
G
YY
G
W-
LP
KE
GT
VEPL
--
P
N
GK
-
-
-----RL
P
T
D
F
N
E
GAK
N
NTY
S
R
NEKMVGYS
F
D
H
E
FNDT
F
T
V
R
Q
N
L
R
F
A
E
N
K
T
S
Q
--
NS
V
YG
-
-
Y
GVCS
D
PANAY
S
KQ
--------
CAALAPADKGHYLA
R
KYVVD
D
EKL
Q
N
F
SV
D
T
Q
L
Q
S
K
F
A
TG
D
I
D
H
T
L
L
---------------
TGV
D
F
M
R
MR
N
DIN
A
W
--------------------
F
G
YD
DSV
P
LLN
-
LY
N
PVN
T
D
-
FDFNAKDPA
N
SG
P
YRIL----
N
KQK
QT
---G
V
Y
V
Q
D
QA
Q
WDKV
L
V
T
L
GG
-
-
--
-
-
--
RYD
W
A
D
Q
------------
ESLNRVAGT
T
D
-----
KRDD
K
QF
TW
R
G
G
VN
Y
-
L
F
DNG
V
T
P
Y
F
SY
S
E
SF
E
-----
P
---------
S
S
-QV
---
G
K
D
G
NI
-
FAP
S
KG
K
Q
YE
V
G
V
K
YVPE
D
R
PI
VV
T
G
A
V
YN
LTKT
N
NLM
--------
A
D
P
EG
S
F
FS
V
EG
G
EI
R
A
R
GVEIE
AK
---
A
A
LS
A
S
VN
V
V
G
S
YT
YTD
AE
YTTD
T
TY
K
GN
TP
AQ
--------
V
P
K
H
MAS
LW
A
D
Y
TFF
D
G
P
LS
G
LT
L
G
T
G
G
RY
T
G
--
S
S
Y---G
D
-
P
A
-
-
N
-S
F
KV
GSY
T
VVDA
LV
RY
D
L
A
R
VGMAG
S
N
V
A
L
H
VNNLFD
RE
YVAS
CFN
T
-
Y
-------
GCFW
GA
E
R
Q
V
VA
TAT
FR
F
fig|340185.3.peg.1605
Escherichia coli E22
MAR
SKT
A
QPK
HSL
RKIAVV
V
A
T
AVS
G
MSVY
AQA
-
A
V
E
PK-
--
EDT
I
T
V
T
A
A
P
---
-
APQ
E
SA
WGPA
ATIAARQSAT
GTK
TDT
P
IQ
K
V
PQS
I
S
VV
T
A
E
E
M
A
LH
Q
PK
S
V
K
EAL
S
Y
TPGV
S
---
V
G
TR
G
A
S
N
T
Y
D
H
L
I
I
-
RGF
-
AAEG
Q
SQ
N
N
Y
L
N
G
L
KL
-------
Q
G
N
FYND
A
VI
D
PYML
ER
A
E
I
M
RGP
V
S
VL
YG
K
S
S
P
G
G
L
L
NMVSK
R
PT
T
EPL
K
-
E
V
QF
KA
G
T
DSLF
Q
TGF
D
FSDS
L
D
DDG
VY
S
Y
R
L
T
G
LA
RS
A
N
A
QQ
K
GSEE
Q
RY
AI
AP
A--
F
T
WR
PDDK
T
NFT
----------
F
L
SYF
Q
N
E--
-
---
P
E
T
G
YY
G
W-
LP
KE
GT
VEPL
--
P
N
GK
-
-
-----RL
P
T
D
F
N
E
GAK
N
NTY
S
R
NEKMVGYS
F
D
H
E
FNDT
F
T
V
R
Q
N
L
R
F
A
E
N
K
T
S
Q
--
NS
V
YG
-
-
Y
GVCS
D
PANAY
S
KQ
--------
CAALAPADKGHYLA
R
KYVVD
D
EKL
Q
N
F
SV
D
T
Q
L
Q
S
K
F
A
TG
D
I
D
H
T
L
L
---------------
TGV
D
F
M
R
MR
N
DIN
A
W
--------------------
F
G
YD
DSV
P
LLN
-
LY
N
PVN
T
D
-
FDFNAKDPA
N
SG
P
YRIL----
N
KQK
QT
---G
V
Y
V
Q
D
QA
Q
WDKV
L
V
T
L
GG
-
-
--
-
-
--
RYD
W
A
D
Q
------------
ESLNRVAGT
T
D
-----
KRDD
K
QF
TW
R
G
G
VN
Y
-
L
F
DNG
V
T
P
Y
F
SY
S
E
SF
E
-----
P
---------
S
S
-QV
---
G
K
D
G
NI
-
FAP
S
KG
K
Q
YE
V
G
V
K
YVPE
D
R
PI
VV
T
G
A
V
YN
LTKT
N
NLM
--------
A
D
P
EG
S
F
FS
V
EG
G
EI
R
A
R
GVEIE
AK
---
A
A
LS
A
S
VN
V
V
G
S
YT
YTD
AE
YTTD
T
TY
K
GN
TP
AQ
--------
V
P
K
H
MAS
LW
A
D
Y
TFF
D
G
P
LS
G
LT
L
G
T
G
G
RY
T
G
--
S
S
Y---G
D
-
P
A
-
-
N
-S
F
KV
GSY
T
VVDA
LV
RY
D
L
A
R
VGMAG
S
N
V
A
L
H
VNNLFD
RE
YVAS
CFN
T
-
Y
-------
GCFW
GA
E
R
Q
V
VA
TAT
FR
F
fig|331111.3.peg.2722
Escherichia coli E24377A
MAR
SKT
A
QPK
HSL
RKIAVV
V
A
T
AVS
G
MSVY
AQA
-
A
V
E
PK-
--
EDT
I
T
V
T
A
A
P
---
-
APQ
E
SA
WGPA
ATIAARQSAT
GTK
TDT
P
IQ
K
V
PQS
I
S
VV
T
A
E
E
M
A
LH
Q
PK
S
V
K
EAL
S
Y
TPGV
S
---
V
G
TR
G
A
S
N
T
Y
D
H
L
I
I
-
RGF
-
AAEG
Q
SQ
N
N
Y
L
N
G
L
KL
-------
Q
G
N
FYND
A
VI
D
PYML
ER
A
E
I
M
RGP
V
S
VL
YG
K
S
S
P
G
G
L
L
NMVSK
R
PT
T
EPL
K
-
E
V
QF
KA
G
T
DSLF
Q
TGF
D
FSDS
L
D
DDG
VY
S
Y
R
L
T
G
LA
RS
A
N
A
QQ
K
GSEE
Q
RY
AI
AP
A--
F
T
WR
PDDK
T
NFT
----------
F
L
SYF
Q
N
E--
-
---
P
E
T
G
YY
G
W-
LP
KE
GT
VEPL
--
P
N
GK
-
-
-----RL
P
T
D
F
N
E
GAK
N
NTY
S
R
NEKMVGYS
F
D
H
E
FNDT
F
T
V
R
Q
N
L
R
F
A
E
N
K
T
S
Q
--
NS
V
YG
-
-
Y
GVCS
D
PANAY
S
KQ
--------
CAALAPADKGHYLA
R
KYVVD
D
EKL
Q
N
F
SV
D
T
Q
L
Q
S
K
F
A
TG
D
I
D
H
T
L
L
---------------
TGV
D
F
M
R
MR
N
DIN
A
W
--------------------
F
G
YD
DSV
P
LLN
-
LY
N
PVN
T
D
-
FDFNAKDPA
N
SG
P
YRIL----
N
KQK
QT
---G
V
Y
V
Q
D
QA
Q
WDKV
L
V
T
L
GG
-
-
--
-
-
--
RYD
W
A
D
Q
------------
ESLNRVAGT
T
D
-----
KRDD
K
QF
TW
R
G
G
VN
Y
-
L
F
DNG
V
T
P
Y
F
SY
S
E
SF
E
-----
P
---------
S
S
-QV
---
G
K
D
G
NI
-
FAP
S
KG
K
Q
YE
V
G
V
K
YVPE
D
R
PI
VV
T
G
A
V
YN
LTKT
N
NLM
--------
A
D
P
EG
S
F
FS
V
EG
G
EI
R
A
R
GVEIE
AK
---
A
A
LS
A
S
VN
V
V
G
S
YT
YTD
AE
YTTD
T
TY
K
GN
TP
AQ
--------
V
P
K
H
MAS
LW
A
D
Y
TFF
D
G
P
LS
G
LT
L
G
T
G
G
RY
T
G
--
S
S
Y---G
D
-
P
A
-
-
N
-S
F
KV
GSY
T
VVDA
LV
RY
D
L
A
R
VGMAG
S
N
V
A
L
H
VNNLFD
RE
YVAS
CFN
T
-
Y
-------
GCFW
GA
E
R
Q
V
VA
TAT
FR
F
fig|562.375.peg.2492
Escherichia coli EC4100B
MAR
SKT
A
QPK
HSL
RKIAVV
V
A
T
AVS
G
MSVY
AQA
-
A
V
E
PK-
--
EDT
I
T
V
T
A
A
P
---
-
APQ
E
SA
WGPA
ATIAARQSAT
GTK
TDT
P
IQ
K
V
PQS
I
S
VV
T
A
E
E
M
A
LH
Q
PK
S
V
K
EAL
S
Y
TPGV
S
---
V
G
TR
G
A
S
N
T
Y
D
H
L
I
I
-
RGF
-
AAEG
Q
SQ
N
N
Y
L
N
G
L
KL
-------
Q
G
N
FYND
A
VI
D
PYML
ER
A
E
I
M
RGP
V
S
VL
YG
K
S
S
P
G
G
L
L
NMVSK
R
PT
T
EPL
K
-
E
V
QF
KA
G
T
DSLF
Q
TGF
D
FSDS
L
D
DDG
VY
S
Y
R
L
T
G
LA
RS
A
N
A
QQ
K
GSEE
Q
RY
AI
AP
A--
F
T
WR
PDDK
T
NFT
----------
F
L
SYF
Q
N
E--
-
---
P
E
T
G
YY
G
W-
LP
KE
GT
VEPL
--
P
N
GK
-
-
-----RL
P
T
D
F
N
E
GAK
N
NTY
S
R
NEKMVGYS
F
D
H
E
FNDT
F
T
V
R
Q
N
L
R
F
A
E
N
K
T
S
Q
--
NS
V
YG
-
-
Y
GVCS
D
PANAY
S
KQ
--------
CAALAPADKGHYLA
R
KYVVD
D
EKL
Q
N
F
SV
D
T
Q
L
Q
S
K
F
A
TG
D
I
D
H
T
L
L
---------------
TGV
D
F
M
R
MR
N
DIN
A
W
--------------------
F
G
YD
DSV
P
LLN
-
LY
N
PVN
T
D
-
FDFNAKDPA
N
SG
P
YRIL----
N
KQK
QT
---G
V
Y
V
Q
D
QA
Q
WDKV
L
V
T
L
GG
-
-
--
-
-
--
RYD
W
A
D
Q
------------
ESLNRVAGT
T
D
-----
KRDD
K
QF
TW
R
G
G
VN
Y
-
L
F
DNG
V
T
P
Y
F
SY
S
E
SF
E
-----
P
---------
S
S
-QV
---
G
K
D
G
NI
-
FAP
S
KG
K
Q
YE
V
G
V
K
YVPE
D
R
PI
VV
T
G
A
V
YN
LTKT
N
NLM
--------
A
D
P
EG
S
F
FS
V
EG
G
EI
R
A
R
GVEIE
AK
---
A
A
LS
A
S
VN
V
V
G
S
YT
YTD
AE
YTTD
T
TY
K
GN
TP
AQ
--------
V
P
K
H
MAS
LW
A
D
Y
TFF
D
G
P
LS
G
LT
L
G
T
G
G
RY
T
G
--
S
S
Y---G
D
-
P
A
-
-
N
-S
F
KV
GSY
T
VVDA
LV
RY
D
L
A
R
VGMAG
S
N
V
A
L
H
VNNLFD
RE
YVAS
CFN
T
-
Y
-------
GCFW
GA
E
R
Q
V
VA
TAT
FR
F
fig|316401.4.peg.164
Escherichia coli ETEC H10407
MAR
SKT
A
QPK
HSL
RKIAVV
V
A
T
AVS
G
MSVY
AQA
-
A
V
E
PK-
--
EDT
I
T
V
T
A
A
P
---
-
APQ
E
SA
WGPA
ATIAARQSAT
GTK
TDT
P
IQ
K
V
PQS
I
S
VV
T
A
E
E
M
A
LH
Q
PK
S
V
K
EAL
S
Y
TPGV
S
---
V
G
TR
G
A
S
N
T
Y
D
H
L
I
I
-
RGF
-
AAEG
Q
SQ
N
N
Y
L
N
G
L
KL
-------
Q
G
N
FYND
A
VI
D
PYML
ER
A
E
I
M
RGP
V
S
VL
YG
K
S
S
P
G
G
L
L
NMVSK
R
PT
T
EPL
K
-
E
V
QF
KA
G
T
DSLF
Q
TGF
D
FSDS
L
D
DDG
VY
S
Y
R
L
T
G
LA
RS
A
N
A
QQ
K
GSEE
Q
RY
AI
AP
A--
F
T
WR
PDDK
T
NFT
----------
F
L
SYF
Q
N
E--
-
---
P
E
T
G
YY
G
W-
LP
KE
GT
VEPL
--
P
N
GK
-
-
-----RL
P
T
D
F
N
E
GAK
N
NTY
S
R
NEKMVGYS
F
D
H
E
FNDT
F
T
V
R
Q
N
L
R
F
A
E
N
K
T
S
Q
--
NS
V
YG
-
-
Y
GVCS
D
PANAY
S
KQ
--------
CAALAPADKGHYLA
R
KYVVD
D
EKL
Q
N
F
SV
D
T
Q
L
Q
S
K
F
A
TG
D
I
D
H
T
L
L
---------------
TGV
D
F
M
R
MR
N
DIN
A
W
--------------------
F
G
YD
DSV
P
LLN
-
LY
N
PVN
T
D
-
FDFNAKDPA
N
SG
P
YRIL----
N
KQK
QT
---G
V
Y
V
Q
D
QA
Q
WDKV
L
V
T
L
GG
-
-
--
-
-
--
RYD
W
A
D
Q
------------
ESLNRVAGT
T
D
-----
KRDD
K
QF
TW
R
G
G
VN
Y
-
L
F
DNG
V
T
P
Y
F
SY
S
E
SF
E
-----
P
---------
S
S
-QV
---
G
K
D
G
NI
-
FAP
S
KG
K
Q
YE
V
G
V
K
YVPE
D
R
PI
VV
T
G
A
V
YN
LTKT
N
NLM
--------
A
D
P
EG
S
F
FS
V
EG
G
EI
R
A
R
GVEIE
AK
---
A
A
LS
A
S
VN
V
V
G
S
YT
YTD
AE
YTTD
T
TY
K
GN
TP
AQ
--------
V
P
K
H
MAS
LW
A
D
Y
TFF
D
G
P
LS
G
LT
L
G
T
G
G
RY
T
G
--
S
S
Y---G
D
-
P
A
-
-
N
-S
F
KV
GSY
T
VVDA
LV
RY
D
L
A
R
VGMAG
S
N
V
A
L
H
VNNLFD
RE
YVAS
CFN
T
-
Y
-------
GCFW
GA
E
R
Q
V
VA
TAT
FR
F
fig|656408.3.peg.5114
Escherichia coli H591
MAR
SKT
A
QPK
HSL
RKIAVV
V
A
T
AVS
G
MSVY
AQA
-
A
V
E
PK-
--
EDT
I
T
V
T
A
A
P
---
-
APQ
E
SA
WGPA
ATIAARQSAT
GTK
TDT
P
IQ
K
V
PQS
I
S
VV
T
A
E
E
M
A
LH
Q
PK
S
V
K
EAL
S
Y
TPGV
S
---
V
G
TR
G
A
S
N
T
Y
D
H
L
I
I
-
RGF
-
AAEG
Q
SQ
N
N
Y
L
N
G
L
KL
-------
Q
G
N
FYND
A
VI
D
PYML
ER
A
E
I
M
RGP
V
S
VL
YG
K
S
S
P
G
G
L
L
NMVSK
R
PT
T
EPL
K
-
E
V
QF
KA
G
T
DSLF
Q
TGF
D
FSDS
L
D
DDG
VY
S
Y
R
L
T
G
LA
RS
A
N
A
QQ
K
GSEE
Q
RY
AI
AP
A--
F
T
WR
PDDK
T
NFT
----------
F
L
SYF
Q
N
E--
-
---
P
E
T
G
YY
G
W-
LP
KE
GT
VEPL
--
P
N
GK
-
-
-----RL
P
T
D
F
N
E
GAK
N
NTY
S
R
NEKMVGYS
F
D
H
E
FNDT
F
T
V
R
Q
N
L
R
F
A
E
N
K
T
S
Q
--
NS
V
YG
-
-
Y
GVCS
D
PANAY
S
KQ
--------
CAALAPADKGHYLA
R
KYVVD
D
EKL
Q
N
F
SV
D
T
Q
L
Q
S
K
F
A
TG
D
I
D
H
T
L
L
---------------
TGV
D
F
M
R
MR
N
DIN
A
W
--------------------
F
G
YD
DSV
P
LLN
-
LY
N
PVN
T
D
-
FDFNAKDPA
N
SG
P
YRIL----
N
KQK
QT
---G
V
Y
V
Q
D
QA
Q
WDKV
L
V
T
L
GG
-
-
--
-
-
--
RYD
W
A
D
Q
------------
ESLNRVAGT
T
D
-----
KRDD
K
QF
TW
R
G
G
VN
Y
-
L
F
DNG
V
T
P
Y
F
SY
S
E
SF
E
-----
P
---------
S
S
-QV
---
G
K
D
G
NI
-
FAP
S
KG
K
Q
YE
V
G
V
K
YVPE
D
R
PI
VV
T
G
A
V
YN
LTKT
N
NLM
--------
A
D
P
EG
S
F
FS
V
EG
G
EI
R
A
R
GVEIE
AK
---
A
A
LS
A
S
VN
V
V
G
S
YT
YTD
AE
YTTD
T
TY
K
GN
TP
AQ
--------
V
P
K
H
MAS
LW
A
D
Y
TFF
D
G
P
LS
G
LT
L
G
T
G
G
RY
T
G
--
S
S
Y---G
D
-
P
A
-
-
N
-S
F
KV
GSY
T
VVDA
LV
RY
D
L
A
R
VGMAG
S
N
V
A
L
H
VNNLFD
RE
YVAS
CFN
T
-
Y
-------
GCFW
GA
E
R
Q
V
VA
TAT
FR
F
fig|585034.4.peg.155
Escherichia coli IAI1
MAR
SKT
A
QPK
HSL
RKIAVV
V
A
T
AVS
G
MSVY
AQA
-
A
V
E
PK-
--
EDT
I
T
V
T
A
A
P
---
-
APQ
E
SA
WGPA
ATIAARQSAT
GTK
TDT
P
IQ
K
V
PQS
I
S
VV
T
A
E
E
M
A
LH
Q
PK
S
V
K
EAL
S
Y
TPGV
S
---
V
G
TR
G
A
S
N
T
Y
D
H
L
I
I
-
RGF
-
AAEG
Q
SQ
N
N
Y
L
N
G
L
KL
-------
Q
G
N
FYND
A
VI
D
PYML
ER
A
E
I
M
RGP
V
S
VL
YG
K
S
S
P
G
G
L
L
NMVSK
R
PT
T
EPL
K
-
E
V
QF
KA
G
T
DSLF
Q
TGF
D
FSDS
L
D
DDG
VY
S
Y
R
L
T
G
LA
RS
A
N
A
QQ
K
GSEE
Q
RY
AI
AP
A--
F
T
WR
PDDK
T
NFT
----------
F
L
SYF
Q
N
E--
-
---
P
E
T
G
YY
G
W-
LP
KE
GT
VEPL
--
P
N
GK
-
-
-----RL
P
T
D
F
N
E
GAK
N
NTY
S
R
NEKMVGYS
F
D
H
E
FNDT
F
T
V
R
Q
N
L
R
F
A
E
N
K
T
S
Q
--
NS
V
YG
-
-
Y
GVCS
D
PANAY
S
KQ
--------
CAALAPADKGHYLA
R
KYVVD
D
EKL
Q
N
F
SV
D
T
Q
L
Q
S
K
F
A
TG
D
I
D
H
T
L
L
---------------
TGV
D
F
M
R
MR
N
DIN
A
W
--------------------
F
G
YD
DSV
P
LLN
-
LY
N
PVN
T
D
-
FDFNAKDPA
N
SG
P
YRIL----
N
KQK
QT
---G
V
Y
V
Q
D
QA
Q
WDKV
L
V
T
L
GG
-
-
--
-
-
--
RYD
W
A
D
Q
------------
ESLNRVAGT
T
D
-----
KRDD
K
QF
TW
R
G
G
VN
Y
-
L
F
DNG
V
T
P
Y
F
SY
S
E
SF
E
-----
P
---------
S
S
-QV
---
G
K
D
G
NI
-
FAP
S
KG
K
Q
YE
V
G
V
K
YVPE
D
R
PI
VV
T
G
A
V
YN
LTKT
N
NLM
--------
A
D
P
EG
S
F
FS
V
EG
G
EI
R
A
R
GVEIE
AK
---
A
A
LS
A
S
VN
V
V
G
S
YT
YTD
AE
YTTD
T
TY
K
GN
TP
AQ
--------
V
P
K
H
MAS
LW
A
D
Y
TFF
D
G
P
LS
G
LT
L
G
T
G
G
RY
T
G
--
S
S
Y---G
D
-
P
A
-
-
N
-S
F
KV
GSY
T
VVDA
LV
RY
D
L
A
R
VGMAG
S
N
V
A
L
H
VNNLFD
RE
YVAS
CFN
T
-
Y
-------
GCFW
GA
E
R
Q
V
VA
TAT
FR
F
fig|585034.5.peg.155
Escherichia coli IAI1
MAR
SKT
A
QPK
HSL
RKIAVV
V
A
T
AVS
G
MSVY
AQA
-
A
V
E
PK-
--
EDT
I
T
V
T
A
A
P
---
-
APQ
E
SA
WGPA
ATIAARQSAT
GTK
TDT
P
IQ
K
V
PQS
I
S
VV
T
A
E
E
M
A
LH
Q
PK
S
V
K
EAL
S
Y
TPGV
S
---
V
G
TR
G
A
S
N
T
Y
D
H
L
I
I
-
RGF
-
AAEG
Q
SQ
N
N
Y
L
N
G
L
KL
-------
Q
G
N
FYND
A
VI
D
PYML
ER
A
E
I
M
RGP
V
S
VL
YG
K
S
S
P
G
G
L
L
NMVSK
R
PT
T
EPL
K
-
E
V
QF
KA
G
T
DSLF
Q
TGF
D
FSDS
L
D
DDG
VY
S
Y
R
L
T
G
LA
RS
A
N
A
QQ
K
GSEE
Q
RY
AI
AP
A--
F
T
WR
PDDK
T
NFT
----------
F
L
SYF
Q
N
E--
-
---
P
E
T
G
YY
G
W-
LP
KE
GT
VEPL
--
P
N
GK
-
-
-----RL
P
T
D
F
N
E
GAK
N
NTY
S
R
NEKMVGYS
F
D
H
E
FNDT
F
T
V
R
Q
N
L
R
F
A
E
N
K
T
S
Q
--
NS
V
YG
-
-
Y
GVCS
D
PANAY
S
KQ
--------
CAALAPADKGHYLA
R
KYVVD
D
EKL
Q
N
F
SV
D
T
Q
L
Q
S
K
F
A
TG
D
I
D
H
T
L
L
---------------
TGV
D
F
M
R
MR
N
DIN
A
W
--------------------
F
G
YD
DSV
P
LLN
-
LY
N
PVN
T
D
-
FDFNAKDPA
N
SG
P
YRIL----
N
KQK
QT
---G
V
Y
V
Q
D
QA
Q
WDKV
L
V
T
L
GG
-
-
--
-
-
--
RYD
W
A
D
Q
------------
ESLNRVAGT
T
D
-----
KRDD
K
QF
TW
R
G
G
VN
Y
-
L
F
DNG
V
T
P
Y
F
SY
S
E
SF
E
-----
P
---------
S
S
-QV
---
G
K
D
G
NI
-
FAP
S
KG
K
Q
YE
V
G
V
K
YVPE
D
R
PI
VV
T
G
A
V
YN
LTKT
N
NLM
--------
A
D
P
EG
S
F
FS
V
EG
G
EI
R
A
R
GVEIE
AK
---
A
A
LS
A
S
VN
V
V
G
S
YT
YTD
AE
YTTD
T
TY
K
GN
TP
AQ
--------
V
P
K
H
MAS
LW
A
D
Y
TFF
D
G
P
LS
G
LT
L
G
T
G
G
RY
T
G
--
S
S
Y---G
D
-
P
A
-
-
N
-S
F
KV
GSY
T
VVDA
LV
RY
D
L
A
R
VGMAG
S
N
V
A
L
H
VNNLFD
RE
YVAS
CFN
T
-
Y
-------
GCFW
GA
E
R
Q
V
VA
TAT
FR
F
fig|83333.1.peg.151
Escherichia coli K12
MAR
SKT
A
QPK
HSL
RKIAVV
V
A
T
AVS
G
MSVY
AQA
-
A
V
E
PK-
--
EDT
I
T
V
T
A
A
P
---
-
APQ
E
SA
WGPA
ATIAARQSAT
GTK
TDT
P
IQ
K
V
PQS
I
S
VV
T
A
E
E
M
A
LH
Q
PK
S
V
K
EAL
S
Y
TPGV
S
---
V
G
TR
G
A
S
N
T
Y
D
H
L
I
I
-
RGF
-
AAEG
Q
SQ
N
N
Y
L
N
G
L
KL
-------
Q
G
N
FYND
A
VI
D
PYML
ER
A
E
I
M
RGP
V
S
VL
YG
K
S
S
P
G
G
L
L
NMVSK
R
PT
T
EPL
K
-
E
V
QF
KA
G
T
DSLF
Q
TGF
D
FSDS
L
D
DDG
VY
S
Y
R
L
T
G
LA
RS
A
N
A
QQ
K
GSEE
Q
RY
AI
AP
A--
F
T
WR
PDDK
T
NFT
----------
F
L
SYF
Q
N
E--
-
---
P
E
T
G
YY
G
W-
LP
KE
GT
VEPL
--
P
N
GK
-
-
-----RL
P
T
D
F
N
E
GAK
N
NTY
S
R
NEKMVGYS
F
D
H
E
FNDT
F
T
V
R
Q
N
L
R
F
A
E
N
K
T
S
Q
--
NS
V
YG
-
-
Y
GVCS
D
PANAY
S
KQ
--------
CAALAPADKGHYLA
R
KYVVD
D
EKL
Q
N
F
SV
D
T
Q
L
Q
S
K
F
A
TG
D
I
D
H
T
L
L
---------------
TGV
D
F
M
R
MR
N
DIN
A
W
--------------------
F
G
YD
DSV
P
LLN
-
LY
N
PVN
T
D
-
FDFNAKDPA
N
SG
P
YRIL----
N
KQK
QT
---G
V
Y
V
Q
D
QA
Q
WDKV
L
V
T
L
GG
-
-
--
-
-
--
RYD
W
A
D
Q
------------
ESLNRVAGT
T
D
-----
KRDD
K
QF
TW
R
G
G
VN
Y
-
L
F
DNG
V
T
P
Y
F
SY
S
E
SF
E
-----
P
---------
S
S
-QV
---
G
K
D
G
NI
-
FAP
S
KG
K
Q
YE
V
G
V
K
YVPE
D
R
PI
VV
T
G
A
V
YN
LTKT
N
NLM
--------
A
D
P
EG
S
F
FS
V
EG
G
EI
R
A
R
GVEIE
AK
---
A
A
LS
A
S
VN
V
V
G
S
YT
YTD
AE
YTTD
T
TY
K
GN
TP
AQ
--------
V
P
K
H
MAS
LW
A
D
Y
TFF
D
G
P
LS
G
LT
L
G
T
G
G
RY
T
G
--
S
S
Y---G
D
-
P
A
-
-
N
-S
F
KV
GSY
T
VVDA
LV
RY
D
L
A
R
VGMAG
S
N
V
A
L
H
VNNLFD
RE
YVAS
CFN
T
-
Y
-------
GCFW
GA
E
R
Q
V
VA
TAT
FR
F
fig|679207.4.peg.1198
Escherichia coli MS 107-1
MAR
SKT
A
QPK
HSL
RKIAVV
V
A
T
AVS
G
MSVY
AQA
-
A
V
E
PK-
--
EDT
I
T
V
T
A
A
P
---
-
APQ
E
SA
WGPA
ATIAARQSAT
GTK
TDT
P
IQ
K
V
PQS
I
S
VV
T
A
E
E
M
A
LH
Q
PK
S
V
K
EAL
S
Y
TPGV
S
---
V
G
TR
G
A
S
N
T
Y
D
H
L
I
I
-
RGF
-
AAEG
Q
SQ
N
N
Y
L
N
G
L
KL
-------
Q
G
N
FYND
A
VI
D
PYML
ER
A
E
I
M
RGP
V
S
VL
YG
K
S
S
P
G
G
L
L
NMVSK
R
PT
T
EPL
K
-
E
V
QF
KA
G
T
DSLF
Q
TGF
D
FSDS
L
D
DDG
VY
S
Y
R
L
T
G
LA
RS
A
N
A
QQ
K
GSEE
Q
RY
AI
AP
A--
F
T
WR
PDDK
T
NFT
----------
F
L
SYF
Q
N
E--
-
---
P
E
T
G
YY
G
W-
LP
KE
GT
VEPL
--
P
N
GK
-
-
-----RL
P
T
D
F
N
E
GAK
N
NTY
S
R
NEKMVGYS
F
D
H
E
FNDT
F
T
V
R
Q
N
L
R
F
A
E
N
K
T
S
Q
--
NS
V
YG
-
-
Y
GVCS
D
PANAY
S
KQ
--------
CAALAPADKGHYLA
R
KYVVD
D
EKL
Q
N
F
SV
D
T
Q
L
Q
S
K
F
A
TG
D
I
D
H
T
L
L
---------------
TGV
D
F
M
R
MR
N
DIN
A
W
--------------------
F
G
YD
DSV
P
LLN
-
LY
N
PVN
T
D
-
FDFNAKDPA
N
SG
P
YRIL----
N
KQK
QT
---G
V
Y
V
Q
D
QA
Q
WDKV
L
V
T
L
GG
-
-
--
-
-
--
RYD
W
A
D
Q
------------
ESLNRVAGT
T
D
-----
KRDD
K
QF
TW
R
G
G
VN
Y
-
L
F
DNG
V
T
P
Y
F
SY
S
E
SF
E
-----
P
---------
S
S
-QV
---
G
K
D
G
NI
-
FAP
S
KG
K
Q
YE
V
G
V
K
YVPE
D
R
PI
VV
T
G
A
V
YN
LTKT
N
NLM
--------
A
D
P
EG
S
F
FS
V
EG
G
EI
R
A
R
GVEIE
AK
---
A
A
LS
A
S
VN
V
V
G
S
YT
YTD
AE
YTTD
T
TY
K
GN
TP
AQ
--------
V
P
K
H
MAS
LW
A
D
Y
TFF
D
G
P
LS
G
LT
L
G
T
G
G
RY
T
G
--
S
S
Y---G
D
-
P
A
-
-
N
-S
F
KV
GSY
T
VVDA
LV
RY
D
L
A
R
VGMAG
S
N
V
A
L
H
VNNLFD
RE
YVAS
CFN
T
-
Y
-------
GCFW
GA
E
R
Q
V
VA
TAT
FR
F
fig|679206.4.peg.3885
Escherichia coli MS 119-7
MAR
SKT
A
QPK
HSL
RKIAVV
V
A
T
AVS
G
MSVY
AQA
-
A
V
E
PK-
--
EDT
I
T
V
T
A
A
P
---
-
APQ
E
SA
WGPA
ATIAARQSAT
GTK
TDT
P
IQ
K
V
PQS
I
S
VV
T
A
E
E
M
A
LH
Q
PK
S
V
K
EAL
S
Y
TPGV
S
---
V
G
TR
G
A
S
N
T
Y
D
H
L
I
I
-
RGF
-
AAEG
Q
SQ
N
N
Y
L
N
G
L
KL
-------
Q
G
N
FYND
A
VI
D
PYML
ER
A
E
I
M
RGP
V
S
VL
YG
K
S
S
P
G
G
L
L
NMVSK
R
PT
T
EPL
K
-
E
V
QF
KA
G
T
DSLF
Q
TGF
D
FSDS
L
D
DDG
VY
S
Y
R
L
T
G
LA
RS
A
N
A
QQ
K
GSEE
Q
RY
AI
AP
A--
F
T
WR
PDDK
T
NFT
----------
F
L
SYF
Q
N
E--
-
---
P
E
T
G
YY
G
W-
LP
KE
GT
VEPL
--
P
N
GK
-
-
-----RL
P
T
D
F
N
E
GAK
N
NTY
S
R
NEKMVGYS
F
D
H
E
FNDT
F
T
V
R
Q
N
L
R
F
A
E
N
K
T
S
Q
--
NS
V
YG
-
-
Y
GVCS
D
PANAY
S
KQ
--------
CAALAPADKGHYLA
R
KYVVD
D
EKL
Q
N
F
SV
D
T
Q
L
Q
S
K
F
A
TG
D
I
D
H
T
L
L
---------------
TGV
D
F
M
R
MR
N
DIN
A
W
--------------------
F
G
YD
DSV
P
LLN
-
LY
N
PVN
T
D
-
FDFNAKDPA
N
SG
P
YRIL----
N
KQK
QT
---G
V
Y
V
Q
D
QA
Q
WDKV
L
V
T
L
GG
-
-
--
-
-
--
RYD
W
A
D
Q
------------
ESLNRVAGT
T
D
-----
KRDD
K
QF
TW
R
G
G
VN
Y
-
L
F
DNG
V
T
P
Y
F
SY
S
E
SF
E
-----
P
---------
S
S
-QV
---
G
K
D
G
NI
-
FAP
S
KG
K
Q
YE
V
G
V
K
YVPE
D
R
PI
VV
T
G
A
V
YN
LTKT
N
NLM
--------
A
D
P
EG
S
F
FS
V
EG
G
EI
R
A
R
GVEIE
AK
---
A
A
LS
A
S
VN
V
V
G
S
YT
YTD
AE
YTTD
T
TY
K
GN
TP
AQ
--------
V
P
K
H
MAS
LW
A
D
Y
TFF
D
G
P
LS
G
LT
L
G
T
G
G
RY
T
G
--
S
S
Y---G
D
-
P
A
-
-
N
-S
F
KV
GSY
T
VVDA
LV
RY
D
L
A
R
VGMAG
S
N
V
A
L
H
VNNLFD
RE
YVAS
CFN
T
-
Y
-------
GCFW
GA
E
R
Q
V
VA
TAT
FR
F
fig|679204.3.peg.3452
Escherichia coli MS 145-7
MAR
SKT
A
QPK
HSL
RKIAVV
V
A
T
AVS
G
MSVY
AQA
-
A
V
E
PK-
--
EDT
I
T
V
T
A
A
P
---
-
APQ
E
SA
WGPA
ATIAARQSAT
GTK
TDT
P
IQ
K
V
PQS
I
S
VV
T
A
E
E
M
A
LH
Q
PK
S
V
K
EAL
S
Y
TPGV
S
---
V
G
TR
G
A
S
N
T
Y
D
H
L
I
I
-
RGF
-
AAEG
Q
SQ
N
N
Y
L
N
G
L
KL
-------
Q
G
N
FYND
A
VI
D
PYML
ER
A
E
I
M
RGP
V
S
VL
YG
K
S
S
P
G
G
L
L
NMVSK
R
PT
T
EPL
K
-
E
V
QF
KA
G
T
DSLF
Q
TGF
D
FSDS
L
D
DDG
VY
S
Y
R
L
T
G
LA
RS
A
N
A
QQ
K
GSEE
Q
RY
AI
AP
A--
F
T
WR
PDDK
T
NFT
----------
F
L
SYF
Q
N
E--
-
---
P
E
T
G
YY
G
W-
LP
KE
GT
VEPL
--
P
N
GK
-
-
-----RL
P
T
D
F
N
E
GAK
N
NTY
S
R
NEKMVGYS
F
D
H
E
FNDT
F
T
V
R
Q
N
L
R
F
A
E
N
K
T
S
Q
--
NS
V
YG
-
-
Y
GVCS
D
PANAY
S
KQ
--------
CAALAPADKGHYLA
R
KYVVD
D
EKL
Q
N
F
SV
D
T
Q
L
Q
S
K
F
A
TG
D
I
D
H
T
L
L
---------------
TGV
D
F
M
R
MR
N
DIN
A
W
--------------------
F
G
YD
DSV
P
LLN
-
LY
N
PVN
T
D
-
FDFNAKDPA
N
SG
P
YRIL----
N
KQK
QT
---G
V
Y
V
Q
D
QA
Q
WDKV
L
V
T
L
GG
-
-
--
-
-
--
RYD
W
A
D
Q
------------
ESLNRVAGT
T
D
-----
KRDD
K
QF
TW
R
G
G
VN
Y
-
L
F
DNG
V
T
P
Y
F
SY
S
E
SF
E
-----
P
---------
S
S
-QV
---
G
K
D
G
NI
-
FAP
S
KG
K
Q
YE
V
G
V
K
YVPE
D
R
PI
VV
T
G
A
V
YN
LTKT
N
NLM
--------
A
D
P
EG
S
F
FS
V
EG
G
EI
R
A
R
GVEIE
AK
---
A
A
LS
A
S
VN
V
V
G
S
YT
YTD
AE
YTTD
T
TY
K
GN
TP
AQ
--------
V
P
K
H
MAS
LW
A
D
Y
TFF
D
G
P
LS
G
LT
L
G
T
G
G
RY
T
G
--
S
S
Y---G
D
-
P
A
-
-
N
-S
F
KV
GSY
T
VVDA
LV
RY
D
L
A
R
VGMAG
S
N
V
A
L
H
VNNLFD
RE
YVAS
CFN
T
-
Y
-------
GCFW
GA
E
R
Q
V
VA
TAT
FR
F
fig|749540.3.peg.2932
Escherichia coli MS 146-1
MAR
SKT
A
QPK
HSL
RKIAVV
V
A
T
AVS
G
MSVY
AQA
-
A
V
E
PK-
--
EDT
I
T
V
T
A
A
P
---
-
APQ
E
SA
WGPA
ATIAARQSAT
GTK
TDT
P
IQ
K
V
PQS
I
S
VV
T
A
E
E
M
A
LH
Q
PK
S
V
K
EAL
S
Y
TPGV
S
---
V
G
TR
G
A
S
N
T
Y
D
H
L
I
I
-
RGF
-
AAEG
Q
SQ
N
N
Y
L
N
G
L
KL
-------
Q
G
N
FYND
A
VI
D
PYML
ER
A
E
I
M
RGP
V
S
VL
YG
K
S
S
P
G
G
L
L
NMVSK
R
PT
T
EPL
K
-
E
V
QF
KA
G
T
DSLF
Q
TGF
D
FSDS
L
D
DDG
VY
S
Y
R
L
T
G
LA
RS
A
N
A
QQ
K
GSEE
Q
RY
AI
AP
A--
F
T
WR
PDDK
T
NFT
----------
F
L
SYF
Q
N
E--
-
---
P
E
T
G
YY
G
W-
LP
KE
GT
VEPL
--
P
N
GK
-
-
-----RL
P
T
D
F
N
E
GAK
N
NTY
S
R
NEKMVGYS
F
D
H
E
FNDT
F
T
V
R
Q
N
L
R
F
A
E
N
K
T
S
Q
--
NS
V
YG
-
-
Y
GVCS
D
PANAY
S
KQ
--------
CAALAPADKGHYLA
R
KYVVD
D
EKL
Q
N
F
SV
D
T
Q
L
Q
S
K
F
A
TG
D
I
D
H
T
L
L
---------------
TGV
D
F
M
R
MR
N
DIN
A
W
--------------------
F
G
YD
DSV
P
LLN
-
LY
N
PVN
T
D
-
FDFNAKDPA
N
SG
P
YRIL----
N
KQK
QT
---G
V
Y
V
Q
D
QA
Q
WDKV
L
V
T
L
GG
-
-
--
-
-
--
RYD
W
A
D
Q
------------
ESLNRVAGT
T
D
-----
KRDD
K
QF
TW
R
G
G
VN
Y
-
L
F
DNG
V
T
P
Y
F
SY
S
E
SF
E
-----
P
---------
S
S
-QV
---
G
K
D
G
NI
-
FAP
S
KG
K
Q
YE
V
G
V
K
YVPE
D
R
PI
VV
T
G
A
V
YN
LTKT
N
NLM
--------
A
D
P
EG
S
F
FS
V
EG
G
EI
R
A
R
GVEIE
AK
---
A
A
LS
A
S
VN
V
V
G
S
YT
YTD
AE
YTTD
T
TY
K
GN
TP
AQ
--------
V
P
K
H
MAS
LW
A
D
Y
TFF
D
G
P
LS
G
LT
L
G
T
G
G
RY
T
G
--
S
S
Y---G
D
-
P
A
-
-
N
-S
F
KV
GSY
T
VVDA
LV
RY
D
L
A
R
VGMAG
S
N
V
A
L
H
VNNLFD
RE
YVAS
CFN
T
-
Y
-------
GCFW
GA
E
R
Q
V
VA
TAT
FR
F
fig|749545.3.peg.1211
Escherichia coli MS 182-1
MAR
SKT
A
QPK
HSL
RKIAVV
V
A
T
AVS
G
MSVY
AQA
-
A
V
E
PK-
--
EDT
I
T
V
T
A
A
P
---
-
APQ
E
SA
WGPA
ATIAARQSAT
GTK
TDT
P
IQ
K
V
PQS
I
S
VV
T
A
E
E
M
A
LH
Q
PK
S
V
K
EAL
S
Y
TPGV
S
---
V
G
TR
G
A
S
N
T
Y
D
H
L
I
I
-
RGF
-
AAEG
Q
SQ
N
N
Y
L
N
G
L
KL
-------
Q
G
N
FYND
A
VI
D
PYML
ER
A
E
I
M
RGP
V
S
VL
YG
K
S
S
P
G
G
L
L
NMVSK
R
PT
T
EPL
K
-
E
V
QF
KA
G
T
DSLF
Q
TGF
D
FSDS
L
D
DDG
VY
S
Y
R
L
T
G
LA
RS
A
N
A
QQ
K
GSEE
Q
RY
AI
AP
A--
F
T
WR
PDDK
T
NFT
----------
F
L
SYF
Q
N
E--
-
---
P
E
T
G
YY
G
W-
LP
KE
GT
VEPL
--
P
N
GK
-
-
-----RL
P
T
D
F
N
E
GAK
N
NTY
S
R
NEKMVGYS
F
D
H
E
FNDT
F
T
V
R
Q
N
L
R
F
A
E
N
K
T
S
Q
--
NS
V
YG
-
-
Y
GVCS
D
PANAY
S
KQ
--------
CAALAPADKGHYLA
R
KYVVD
D
EKL
Q
N
F
SV
D
T
Q
L
Q
S
K
F
A
TG
D
I
D
H
T
L
L
---------------
TGV
D
F
M
R
MR
N
DIN
A
W
--------------------
F
G
YD
DSV
P
LLN
-
LY
N
PVN
T
D
-
FDFNAKDPA
N
SG
P
YRIL----
N
KQK
QT
---G
V
Y
V
Q
D
QA
Q
WDKV
L
V
T
L
GG
-
-
--
-
-
--
RYD
W
A
D
Q
------------
ESLNRVAGT
T
D
-----
KRDD
K
QF
TW
R
G
G
VN
Y
-
L
F
DNG
V
T
P
Y
F
SY
S
E
SF
E
-----
P
---------
S
S
-QV
---
G
K
D
G
NI
-
FAP
S
KG
K
Q
YE
V
G
V
K
YVPE
D
R
PI
VV
T
G
A
V
YN
LTKT
N
NLM
--------
A
D
P
EG
S
F
FS
V
EG
G
EI
R
A
R
GVEIE
AK
---
A
A
LS
A
S
VN
V
V
G
S
YT
YTD
AE
YTTD
T
TY
K
GN
TP
AQ
--------
V
P
K
H
MAS
LW
A
D
Y
TFF
D
G
P
LS
G
LT
L
G
T
G
G
RY
T
G
--
S
S
Y---G
D
-
P
A
-
-
N
-S
F
KV
GSY
T
VVDA
LV
RY
D
L
A
R
VGMAG
S
N
V
A
L
H
VNNLFD
RE
YVAS
CFN
T
-
Y
-------
GCFW
GA
E
R
Q
V
VA
TAT
FR
F
fig|585395.4.peg.154
Escherichia coli O103:H2 str. 12009
MAR
SKT
A
QPK
HSL
RKIAVV
V
A
T
AVS
G
MSVY
AQA
-
A
V
E
PK-
--
EDT
I
T
V
T
A
A
P
---
-
APQ
E
SA
WGPA
ATIAARQSAT
GTK
TDT
P
IQ
K
V
PQS
I
S
VV
T
A
E
E
M
A
LH
Q
PK
S
V
K
EAL
S
Y
TPGV
S
---
V
G
TR
G
A
S
N
T
Y
D
H
L
I
I
-
RGF
-
AAEG
Q
SQ
N
N
Y
L
N
G
L
KL
-------
Q
G
N
FYND
A
VI
D
PYML
ER
A
E
I
M
RGP
V
S
VL
YG
K
S
S
P
G
G
L
L
NMVSK
R
PT
T
EPL
K
-
E
V
QF
KA
G
T
DSLF
Q
TGF
D
FSDS
L
D
DDG
VY
S
Y
R
L
T
G
LA
RS
A
N
A
QQ
K
GSEE
Q
RY
AI
AP
A--
F
T
WR
PDDK
T
NFT
----------
F
L
SYF
Q
N
E--
-
---
P
E
T
G
YY
G
W-
LP
KE
GT
VEPL
--
P
N
GK
-
-
-----RL
P
T
D
F
N
E
GAK
N
NTY
S
R
NEKMVGYS
F
D
H
E
FNDT
F
T
V
R
Q
N
L
R
F
A
E
N
K
T
S
Q
--
NS
V
YG
-
-
Y
GVCS
D
PANAY
S
KQ
--------
CAALAPADKGHYLA
R
KYVVD
D
EKL
Q
N
F
SV
D
T
Q
L
Q
S
K
F
A
TG
D
I
D
H
T
L
L
---------------
TGV
D
F
M
R
MR
N
DIN
A
W
--------------------
F
G
YD
DSV
P
LLN
-
LY
N
PVN
T
D
-
FDFNAKDPA
N
SG
P
YRIL----
N
KQK
QT
---G
V
Y
V
Q
D
QA
Q
WDKV
L
V
T
L
GG
-
-
--
-
-
--
RYD
W
A
D
Q
------------
ESLNRVAGT
T
D
-----
KRDD
K
QF
TW
R
G
G
VN
Y
-
L
F
DNG
V
T
P
Y
F
SY
S
E
SF
E
-----
P
---------
S
S
-QV
---
G
K
D
G
NI
-
FAP
S
KG
K
Q
YE
V
G
V
K
YVPE
D
R
PI
VV
T
G
A
V
YN
LTKT
N
NLM
--------
A
D
P
EG
S
F
FS
V
EG
G
EI
R
A
R
GVEIE
AK
---
A
A
LS
A
S
VN
V
V
G
S
YT
YTD
AE
YTTD
T
TY
K
GN
TP
AQ
--------
V
P
K
H
MAS
LW
A
D
Y
TFF
D
G
P
LS
G
LT
L
G
T
G
G
RY
T
G
--
S
S
Y---G
D
-
P
A
-
-
N
-S
F
KV
GSY
T
VVDA
LV
RY
D
L
A
R
VGMAG
S
N
V
A
L
H
VNNLFD
RE
YVAS
CFN
T
-
Y
-------
GCFW
GA
E
R
Q
V
VA
TAT
FR
F
fig|585396.4.peg.156
Escherichia coli O111:H- str. 11128
MAR
SKT
A
QPK
HSL
RKIAVV
V
A
T
AVS
G
MSVY
AQA
-
A
V
E
PK-
--
EDT
I
T
V
T
A
A
P
---
-
APQ
E
SA
WGPA
ATIAARQSAT
GTK
TDT
P
IQ
K
V
PQS
I
S
VV
T
A
E
E
M
A
LH
Q
PK
S
V
K
EAL
S
Y
TPGV
S
---
V
G
TR
G
A
S
N
T
Y
D
H
L
I
I
-
RGF
-
AAEG
Q
SQ
N
N
Y
L
N
G
L
KL
-------
Q
G
N
FYND
A
VI
D
PYML
ER
A
E
I
M
RGP
V
S
VL
YG
K
S
S
P
G
G
L
L
NMVSK
R
PT
T
EPL
K
-
E
V
QF
KA
G
T
DSLF
Q
TGF
D
FSDS
L
D
DDG
VY
S
Y
R
L
T
G
LA
RS
A
N
A
QQ
K
GSEE
Q
RY
AI
AP
A--
F
T
WR
PDDK
T
NFT
----------
F
L
SYF
Q
N
E--
-
---
P
E
T
G
YY
G
W-
LP
KE
GT
VEPL
--
P
N
GK
-
-
-----RL
P
T
D
F
N
E
GAK
N
NTY
S
R
NEKMVGYS
F
D
H
E
FNDT
F
T
V
R
Q
N
L
R
F
A
E
N
K
T
S
Q
--
NS
V
YG
-
-
Y
GVCS
D
PANAY
S
KQ
--------
CAALAPADKGHYLA
R
KYVVD
D
EKL
Q
N
F
SV
D
T
Q
L
Q
S
K
F
A
TG
D
I
D
H
T
L
L
---------------
TGV
D
F
M
R
MR
N
DIN
A
W
--------------------
F
G
YD
DSV
P
LLN
-
LY
N
PVN
T
D
-
FDFNAKDPA
N
SG
P
YRIL----
N
KQK
QT
---G
V
Y
V
Q
D
QA
Q
WDKV
L
V
T
L
GG
-
-
--
-
-
--
RYD
W
A
D
Q
------------
ESLNRVAGT
T
D
-----
KRDD
K
QF
TW
R
G
G
VN
Y
-
L
F
DNG
V
T
P
Y
F
SY
S
E
SF
E
-----
P
---------
S
S
-QV
---
G
K
D
G
NI
-
FAP
S
KG
K
Q
YE
V
G
V
K
YVPE
D
R
PI
VV
T
G
A
V
YN
LTKT
N
NLM
--------
A
D
P
EG
S
F
FS
V
EG
G
EI
R
A
R
GVEIE
AK
---
A
A
LS
A
S
VN
V
V
G
S
YT
YTD
AE
YTTD
T
TY
K
GN
TP
AQ
--------
V
P
K
H
MAS
LW
A
D
Y
TFF
D
G
P
LS
G
LT
L
G
T
G
G
RY
T
G
--
S
S
Y---G
D
-
P
A
-
-
N
-S
F
KV
GSY
T
VVDA
LV
RY
D
L
A
R
VGMAG
S
N
V
A
L
H
VNNLFD
RE
YVAS
CFN
T
-
Y
-------
GCFW
GA
E
R
Q
V
VA
TAT
FR
F
fig|656443.3.peg.295
Escherichia coli TA271
MAR
SKT
A
QPK
HSL
RKIAVV
V
A
T
AVS
G
MSVY
AQA
-
A
V
E
PK-
--
EDT
I
T
V
T
A
A
P
---
-
APQ
E
SA
WGPA
ATIAARQSAT
GTK
TDT
P
IQ
K
V
PQS
I
S
VV
T
A
E
E
M
A
LH
Q
PK
S
V
K
EAL
S
Y
TPGV
S
---
V
G
TR
G
A
S
N
T
Y
D
H
L
I
I
-
RGF
-
AAEG
Q
SQ
N
N
Y
L
N
G
L
KL
-------
Q
G
N
FYND
A
VI
D
PYML
ER
A
E
I
M
RGP
V
S
VL
YG
K
S
S
P
G
G
L
L
NMVSK
R
PT
T
EPL
K
-
E
V
QF
KA
G
T
DSLF
Q
TGF
D
FSDS
L
D
DDG
VY
S
Y
R
L
T
G
LA
RS
A
N
A
QQ
K
GSEE
Q
RY
AI
AP
A--
F
T
WR
PDDK
T
NFT
----------
F
L
SYF
Q
N
E--
-
---
P
E
T
G
YY
G
W-
LP
KE
GT
VEPL
--
P
N
GK
-
-
-----RL
P
T
D
F
N
E
GAK
N
NTY
S
R
NEKMVGYS
F
D
H
E
FNDT
F
T
V
R
Q
N
L
R
F
A
E
N
K
T
S
Q
--
NS
V
YG
-
-
Y
GVCS
D
PANAY
S
KQ
--------
CAALAPADKGHYLA
R
KYVVD
D
EKL
Q
N
F
SV
D
T
Q
L
Q
S
K
F
A
TG
D
I
D
H
T
L
L
---------------
TGV
D
F
M
R
MR
N
DIN
A
W
--------------------
F
G
YD
DSV
P
LLN
-
LY
N
PVN
T
D
-
FDFNAKDPA
N
SG
P
YRIL----
N
KQK
QT
---G
V
Y
V
Q
D
QA
Q
WDKV
L
V
T
L
GG
-
-
--
-
-
--
RYD
W
A
D
Q
------------
ESLNRVAGT
T
D
-----
KRDD
K
QF
TW
R
G
G
VN
Y
-
L
F
DNG
V
T
P
Y
F
SY
S
E
SF
E
-----
P
---------
S
S
-QV
---
G
K
D
G
NI
-
FAP
S
KG
K
Q
YE
V
G
V
K
YVPE
D
R
PI
VV
T
G
A
V
YN
LTKT
N
NLM
--------
A
D
P
EG
S
F
FS
V
EG
G
EI
R
A
R
GVEIE
AK
---
A
A
LS
A
S
VN
V
V
G
S
YT
YTD
AE
YTTD
T
TY
K
GN
TP
AQ
--------
V
P
K
H
MAS
LW
A
D
Y
TFF
D
G
P
LS
G
LT
L
G
T
G
G
RY
T
G
--
S
S
Y---G
D
-
P
A
-
-
N
-S
F
KV
GSY
T
VVDA
LV
RY
D
L
A
R
VGMAG
S
N
V
A
L
H
VNNLFD
RE
YVAS
CFN
T
-
Y
-------
GCFW
GA
E
R
Q
V
VA
TAT
FR
F
fig|316407.3.peg.147
Escherichia coli W3110
MAR
SKT
A
QPK
HSL
RKIAVV
V
A
T
AVS
G
MSVY
AQA
-
A
V
E
PK-
--
EDT
I
T
V
T
A
A
P
---
-
APQ
E
SA
WGPA
ATIAARQSAT
GTK
TDT
P
IQ
K
V
PQS
I
S
VV
T
A
E
E
M
A
LH
Q
PK
S
V
K
EAL
S
Y
TPGV
S
---
V
G
TR
G
A
S
N
T
Y
D
H
L
I
I
-
RGF
-
AAEG
Q
SQ
N
N
Y
L
N
G
L
KL
-------
Q
G
N
FYND
A
VI
D
PYML
ER
A
E
I
M
RGP
V
S
VL
YG
K
S
S
P
G
G
L
L
NMVSK
R
PT
T
EPL
K
-
E
V
QF
KA
G
T
DSLF
Q
TGF
D
FSDS
L
D
DDG
VY
S
Y
R
L
T
G
LA
RS
A
N
A
QQ
K
GSEE
Q
RY
AI
AP
A--
F
T
WR
PDDK
T
NFT
----------
F
L
SYF
Q
N
E--
-
---
P
E
T
G
YY
G
W-
LP
KE
GT
VEPL
--
P
N
GK
-
-
-----RL
P
T
D
F
N
E
GAK
N
NTY
S
R
NEKMVGYS
F
D
H
E
FNDT
F
T
V
R
Q
N
L
R
F
A
E
N
K
T
S
Q
--
NS
V
YG
-
-
Y
GVCS
D
PANAY
S
KQ
--------
CAALAPADKGHYLA
R
KYVVD
D
EKL
Q
N
F
SV
D
T
Q
L
Q
S
K
F
A
TG
D
I
D
H
T
L
L
---------------
TGV
D
F
M
R
MR
N
DIN
A
W
--------------------
F
G
YD
DSV
P
LLN
-
LY
N
PVN
T
D
-
FDFNAKDPA
N
SG
P
YRIL----
N
KQK
QT
---G
V
Y
V
Q
D
QA
Q
WDKV
L
V
T
L
GG
-
-
--
-
-
--
RYD
W
A
D
Q
------------
ESLNRVAGT
T
D
-----
KRDD
K
QF
TW
R
G
G
VN
Y
-
L
F
DNG
V
T
P
Y
F
SY
S
E
SF
E
-----
P
---------
S
S
-QV
---
G
K
D
G
NI
-
FAP
S
KG
K
Q
YE
V
G
V
K
YVPE
D
R
PI
VV
T
G
A
V
YN
LTKT
N
NLM
--------
A
D
P
EG
S
F
FS
V
EG
G
EI
R
A
R
GVEIE
AK
---
A
A
LS
A
S
VN
V
V
G
S
YT
YTD
AE
YTTD
T
TY
K
GN
TP
AQ
--------
V
P
K
H
MAS
LW
A
D
Y
TFF
D
G
P
LS
G
LT
L
G
T
G
G
RY
T
G
--
S
S
Y---G
D
-
P
A
-
-
N
-S
F
KV
GSY
T
VVDA
LV
RY
D
L
A
R
VGMAG
S
N
V
A
L
H
VNNLFD
RE
YVAS
CFN
T
-
Y
-------
GCFW
GA
E
R
Q
V
VA
TAT
FR
F
fig|511145.12.peg.156
Escherichia coli str. K-12 substr. MG1655
MAR
SKT
A
QPK
HSL
RKIAVV
V
A
T
AVS
G
MSVY
AQA
-
A
V
E
PK-
--
EDT
I
T
V
T
A
A
P
---
-
APQ
E
SA
WGPA
ATIAARQSAT
GTK
TDT
P
IQ
K
V
PQS
I
S
VV
T
A
E
E
M
A
LH
Q
PK
S
V
K
EAL
S
Y
TPGV
S
---
V
G
TR
G
A
S
N
T
Y
D
H
L
I
I
-
RGF
-
AAEG
Q
SQ
N
N
Y
L
N
G
L
KL
-------
Q
G
N
FYND
A
VI
D
PYML
ER
A
E
I
M
RGP
V
S
VL
YG
K
S
S
P
G
G
L
L
NMVSK
R
PT
T
EPL
K
-
E
V
QF
KA
G
T
DSLF
Q
TGF
D
FSDS
L
D
DDG
VY
S
Y
R
L
T
G
LA
RS
A
N
A
QQ
K
GSEE
Q
RY
AI
AP
A--
F
T
WR
PDDK
T
NFT
----------
F
L
SYF
Q
N
E--
-
---
P
E
T
G
YY
G
W-
LP
KE
GT
VEPL
--
P
N
GK
-
-
-----RL
P
T
D
F
N
E
GAK
N
NTY
S
R
NEKMVGYS
F
D
H
E
FNDT
F
T
V
R
Q
N
L
R
F
A
E
N
K
T
S
Q
--
NS
V
YG
-
-
Y
GVCS
D
PANAY
S
KQ
--------
CAALAPADKGHYLA
R
KYVVD
D
EKL
Q
N
F
SV
D
T
Q
L
Q
S
K
F
A
TG
D
I
D
H
T
L
L
---------------
TGV
D
F
M
R
MR
N
DIN
A
W
--------------------
F
G
YD
DSV
P
LLN
-
LY
N
PVN
T
D
-
FDFNAKDPA
N
SG
P
YRIL----
N
KQK
QT
---G
V
Y
V
Q
D
QA
Q
WDKV
L
V
T
L
GG
-
-
--
-
-
--
RYD
W
A
D
Q
------------
ESLNRVAGT
T
D
-----
KRDD
K
QF
TW
R
G
G
VN
Y
-
L
F
DNG
V
T
P
Y
F
SY
S
E
SF
E
-----
P
---------
S
S
-QV
---
G
K
D
G
NI
-
FAP
S
KG
K
Q
YE
V
G
V
K
YVPE
D
R
PI
VV
T
G
A
V
YN
LTKT
N
NLM
--------
A
D
P
EG
S
F
FS
V
EG
G
EI
R
A
R
GVEIE
AK
---
A
A
LS
A
S
VN
V
V
G
S
YT
YTD
AE
YTTD
T
TY
K
GN
TP
AQ
--------
V
P
K
H
MAS
LW
A
D
Y
TFF
D
G
P
LS
G
LT
L
G
T
G
G
RY
T
G
--
S
S
Y---G
D
-
P
A
-
-
N
-S
F
KV
GSY
T
VVDA
LV
RY
D
L
A
R
VGMAG
S
N
V
A
L
H
VNNLFD
RE
YVAS
CFN
T
-
Y
-------
GCFW
GA
E
R
Q
V
VA
TAT
FR
F
fig|511145.6.peg.155
Escherichia coli str. K-12 substr. MG1655
MAR
SKT
A
QPK
HSL
RKIAVV
V
A
T
AVS
G
MSVY
AQA
-
A
V
E
PK-
--
EDT
I
T
V
T
A
A
P
---
-
APQ
E
SA
WGPA
ATIAARQSAT
GTK
TDT
P
IQ
K
V
PQS
I
S
VV
T
A
E
E
M
A
LH
Q
PK
S
V
K
EAL
S
Y
TPGV
S
---
V
G
TR
G
A
S
N
T
Y
D
H
L
I
I
-
RGF
-
AAEG
Q
SQ
N
N
Y
L
N
G
L
KL
-------
Q
G
N
FYND
A
VI
D
PYML
ER
A
E
I
M
RGP
V
S
VL
YG
K
S
S
P
G
G
L
L
NMVSK
R
PT
T
EPL
K
-
E
V
QF
KA
G
T
DSLF
Q
TGF
D
FSDS
L
D
DDG
VY
S
Y
R
L
T
G
LA
RS
A
N
A
QQ
K
GSEE
Q
RY
AI
AP
A--
F
T
WR
PDDK
T
NFT
----------
F
L
SYF
Q
N
E--
-
---
P
E
T
G
YY
G
W-
LP
KE
GT
VEPL
--
P
N
GK
-
-
-----RL
P
T
D
F
N
E
GAK
N
NTY
S
R
NEKMVGYS
F
D
H
E
FNDT
F
T
V
R
Q
N
L
R
F
A
E
N
K
T
S
Q
--
NS
V
YG
-
-
Y
GVCS
D
PANAY
S
KQ
--------
CAALAPADKGHYLA
R
KYVVD
D
EKL
Q
N
F
SV
D
T
Q
L
Q
S
K
F
A
TG
D
I
D
H
T
L
L
---------------
TGV
D
F
M
R
MR
N
DIN
A
W
--------------------
F
G
YD
DSV
P
LLN
-
LY
N
PVN
T
D
-
FDFNAKDPA
N
SG
P
YRIL----
N
KQK
QT
---G
V
Y
V
Q
D
QA
Q
WDKV
L
V
T
L
GG
-
-
--
-
-
--
RYD
W
A
D
Q
------------
ESLNRVAGT
T
D
-----
KRDD
K
QF
TW
R
G
G
VN
Y
-
L
F
DNG
V
T
P
Y
F
SY
S
E
SF
E
-----
P
---------
S
S
-QV
---
G
K
D
G
NI
-
FAP
S
KG
K
Q
YE
V
G
V
K
YVPE
D
R
PI
VV
T
G
A
V
YN
LTKT
N
NLM
--------
A
D
P
EG
S
F
FS
V
EG
G
EI
R
A
R
GVEIE
AK
---
A
A
LS
A
S
VN
V
V
G
S
YT
YTD
AE
YTTD
T
TY
K
GN
TP
AQ
--------
V
P
K
H
MAS
LW
A
D
Y
TFF
D
G
P
LS
G
LT
L
G
T
G
G
RY
T
G
--
S
S
Y---G
D
-
P
A
-
-
N
-S
F
KV
GSY
T
VVDA
LV
RY
D
L
A
R
VGMAG
S
N
V
A
L
H
VNNLFD
RE
YVAS
CFN
T
-
Y
-------
GCFW
GA
E
R
Q
V
VA
TAT
FR
F
fig|595495.4.peg.3974
Escherichia coli KO11
MAR
SKT
A
QPK
HSL
RKIAVV
V
A
T
AVS
G
MSVY
AQA
-
A
V
E
PK-
--
EDT
I
T
V
T
A
A
P
---
-
APQ
E
SA
WGPA
ATIAARQSAT
GTK
TDT
P
IQ
K
V
PQS
I
S
VV
T
A
E
E
M
A
LH
Q
PK
S
V
K
EAL
S
Y
TPGV
S
---
V
G
TR
G
A
S
N
T
Y
D
H
L
I
I
-
RGF
-
AAEG
Q
SQ
N
N
Y
L
N
G
L
KL
-------
Q
G
N
FYND
A
VI
D
PYML
ER
A
E
I
M
RGP
V
S
VL
YG
K
S
S
P
G
G
L
L
NMVSK
R
PT
T
EPM
K
-
E
V
QF
KA
G
T
DSLF
Q
TGF
D
FSDS
L
D
DDG
VY
S
Y
R
L
T
G
LA
RS
A
N
A
QQ
K
GSEE
Q
RY
AI
AP
A--
F
T
WR
PDDK
T
NFT
----------
F
L
SYF
Q
N
E--
-
---
P
E
T
G
YY
G
W-
LP
KE
GT
VEPL
--
P
N
GK
-
-
-----RL
P
T
D
F
N
E
GAK
N
NTY
S
R
NEKMVGYS
F
D
H
E
FNDT
F
T
V
R
Q
N
L
R
F
A
E
N
K
T
S
Q
--
NS
V
YG
-
-
Y
GVCS
D
PANAY
S
KQ
--------
CAALAPADKGHYLA
R
KYVVD
D
EKL
Q
N
F
SV
D
T
Q
L
Q
S
K
F
A
TG
D
I
D
H
T
L
L
---------------
TGV
D
F
M
R
MR
N
DIN
A
W
--------------------
F
G
YD
DSV
P
LLN
-
LY
N
PVN
T
D
-
FDFNAKDPA
N
SG
P
YRIL----
N
KQK
QT
---G
V
Y
V
Q
D
QA
Q
WDKV
L
V
T
L
GG
-
-
--
-
-
--
RYD
W
A
D
Q
------------
ESLNRVAGT
T
D
-----
KRDD
K
QF
TW
R
G
G
VN
Y
-
L
F
DNG
V
T
P
Y
F
SY
S
E
SF
E
-----
P
---------
S
S
-QV
---
G
K
D
G
NI
-
FAP
S
KG
K
Q
YE
V
G
V
K
YVPE
D
R
PI
VV
T
G
A
V
YN
LTKT
N
NLM
--------
A
D
P
EG
S
F
FS
V
EG
G
EI
R
A
R
GVEIE
AK
---
A
A
LS
A
S
VN
V
V
G
S
YT
YTD
AE
YTTD
T
TY
K
GN
TP
AQ
--------
V
P
K
H
MAS
LW
A
D
Y
TFF
D
G
P
LS
G
LT
L
G
T
G
G
RY
T
G
--
S
S
Y---G
D
-
P
A
-
-
N
-S
F
KV
GSY
T
VVDA
LV
RY
D
L
A
R
VGMAG
S
N
V
A
L
H
VNNLFD
RE
YVAS
CFN
T
-
Y
-------
GCFW
GA
E
R
Q
V
VA
TAT
FR
F
fig|566546.3.peg.1573
Escherichia coli W
MAR
SKT
A
QPK
HSL
RKIAVV
V
A
T
AVS
G
MSVY
AQA
-
A
V
E
PK-
--
EDT
I
T
V
T
A
A
P
---
-
APQ
E
SA
WGPA
ATIAARQSAT
GTK
TDT
P
IQ
K
V
PQS
I
S
VV
T
A
E
E
M
A
LH
Q
PK
S
V
K
EAL
S
Y
TPGV
S
---
V
G
TR
G
A
S
N
T
Y
D
H
L
I
I
-
RGF
-
AAEG
Q
SQ
N
N
Y
L
N
G
L
KL
-------
Q
G
N
FYND
A
VI
D
PYML
ER
A
E
I
M
RGP
V
S
VL
YG
K
S
S
P
G
G
L
L
NMVSK
R
PT
T
EPM
K
-
E
V
QF
KA
G
T
DSLF
Q
TGF
D
FSDS
L
D
DDG
VY
S
Y
R
L
T
G
LA
RS
A
N
A
QQ
K
GSEE
Q
RY
AI
AP
A--
F
T
WR
PDDK
T
NFT
----------
F
L
SYF
Q
N
E--
-
---
P
E
T
G
YY
G
W-
LP
KE
GT
VEPL
--
P
N
GK
-
-
-----RL
P
T
D
F
N
E
GAK
N
NTY
S
R
NEKMVGYS
F
D
H
E
FNDT
F
T
V
R
Q
N
L
R
F
A
E
N
K
T
S
Q
--
NS
V
YG
-
-
Y
GVCS
D
PANAY
S
KQ
--------
CAALAPADKGHYLA
R
KYVVD
D
EKL
Q
N
F
SV
D
T
Q
L
Q
S
K
F
A
TG
D
I
D
H
T
L
L
---------------
TGV
D
F
M
R
MR
N
DIN
A
W
--------------------
F
G
YD
DSV
P
LLN
-
LY
N
PVN
T
D
-
FDFNAKDPA
N
SG
P
YRIL----
N
KQK
QT
---G
V
Y
V
Q
D
QA
Q
WDKV
L
V
T
L
GG
-
-
--
-
-
--
RYD
W
A
D
Q
------------
ESLNRVAGT
T
D
-----
KRDD
K
QF
TW
R
G
G
VN
Y
-
L
F
DNG
V
T
P
Y
F
SY
S
E
SF
E
-----
P
---------
S
S
-QV
---
G
K
D
G
NI
-
FAP
S
KG
K
Q
YE
V
G
V
K
YVPE
D
R
PI
VV
T
G
A
V
YN
LTKT
N
NLM
--------
A
D
P
EG
S
F
FS
V
EG
G
EI
R
A
R
GVEIE
AK
---
A
A
LS
A
S
VN
V
V
G
S
YT
YTD
AE
YTTD
T
TY
K
GN
TP
AQ
--------
V
P
K
H
MAS
LW
A
D
Y
TFF
D
G
P
LS
G
LT
L
G
T
G
G
RY
T
G
--
S
S
Y---G
D
-
P
A
-
-
N
-S
F
KV
GSY
T
VVDA
LV
RY
D
L
A
R
VGMAG
S
N
V
A
L
H
VNNLFD
RE
YVAS
CFN
T
-
Y
-------
GCFW
GA
E
R
Q
V
VA
TAT
FR
F
fig|566546.4.peg.150
Escherichia coli W
MAR
SKT
A
QPK
HSL
RKIAVV
V
A
T
AVS
G
MSVY
AQA
-
A
V
E
PK-
--
EDT
I
T
V
T
A
A
P
---
-
APQ
E
SA
WGPA
ATIAARQSAT
GTK
TDT
P
IQ
K
V
PQS
I
S
VV
T
A
E
E
M
A
LH
Q
PK
S
V
K
EAL
S
Y
TPGV
S
---
V
G
TR
G
A
S
N
T
Y
D
H
L
I
I
-
RGF
-
AAEG
Q
SQ
N
N
Y
L
N
G
L
KL
-------
Q
G
N
FYND
A
VI
D
PYML
ER
A
E
I
M
RGP
V
S
VL
YG
K
S
S
P
G
G
L
L
NMVSK
R
PT
T
EPM
K
-
E
V
QF
KA
G
T
DSLF
Q
TGF
D
FSDS
L
D
DDG
VY
S
Y
R
L
T
G
LA
RS
A
N
A
QQ
K
GSEE
Q
RY
AI
AP
A--
F
T
WR
PDDK
T
NFT
----------
F
L
SYF
Q
N
E--
-
---
P
E
T
G
YY
G
W-
LP
KE
GT
VEPL
--
P
N
GK
-
-
-----RL
P
T
D
F
N
E
GAK
N
NTY
S
R
NEKMVGYS
F
D
H
E
FNDT
F
T
V
R
Q
N
L
R
F
A
E
N
K
T
S
Q
--
NS
V
YG
-
-
Y
GVCS
D
PANAY
S
KQ
--------
CAALAPADKGHYLA
R
KYVVD
D
EKL
Q
N
F
SV
D
T
Q
L
Q
S
K
F
A
TG
D
I
D
H
T
L
L
---------------
TGV
D
F
M
R
MR
N
DIN
A
W
--------------------
F
G
YD
DSV
P
LLN
-
LY
N
PVN
T
D
-
FDFNAKDPA
N
SG
P
YRIL----
N
KQK
QT
---G
V
Y
V
Q
D
QA
Q
WDKV
L
V
T
L
GG
-
-
--
-
-
--
RYD
W
A
D
Q
------------
ESLNRVAGT
T
D
-----
KRDD
K
QF
TW
R
G
G
VN
Y
-
L
F
DNG
V
T
P
Y
F
SY
S
E
SF
E
-----
P
---------
S
S
-QV
---
G
K
D
G
NI
-
FAP
S
KG
K
Q
YE
V
G
V
K
YVPE
D
R
PI
VV
T
G
A
V
YN
LTKT
N
NLM
--------
A
D
P
EG
S
F
FS
V
EG
G
EI
R
A
R
GVEIE
AK
---
A
A
LS
A
S
VN
V
V
G
S
YT
YTD
AE
YTTD
T
TY
K
GN
TP
AQ
--------
V
P
K
H
MAS
LW
A
D
Y
TFF
D
G
P
LS
G
LT
L
G
T
G
G
RY
T
G
--
S
S
Y---G
D
-
P
A
-
-
N
-S
F
KV
GSY
T
VVDA
LV
RY
D
L
A
R
VGMAG
S
N
V
A
L
H
VNNLFD
RE
YVAS
CFN
T
-
Y
-------
GCFW
GA
E
R
Q
V
VA
TAT
FR
F
fig|749544.3.peg.1800
Escherichia coli MS 175-1
MAR
SKT
A
QPK
HSL
RKIAVV
V
A
T
AVS
G
MSVY
AQA
-
A
V
E
PK-
--
EDT
I
T
V
T
A
A
P
---
-
APQ
E
SA
WGPA
ATIAARQSAT
GTK
TDT
P
IQ
K
V
PQS
I
S
VV
T
A
E
E
M
A
LH
Q
PK
S
V
K
EAL
S
Y
TPGV
S
---
V
G
TR
G
A
S
N
T
Y
D
H
L
I
I
-
RGF
-
AAEG
Q
SQ
N
N
Y
L
N
G
L
KL
-------
Q
G
N
FYND
A
VI
D
PYML
ER
A
E
I
M
RGP
V
S
VL
YG
K
S
S
P
G
G
L
L
NMVSK
R
PT
T
EPL
K
-
E
V
QF
KA
G
T
DSLF
Q
TGF
D
FSDS
L
D
DDG
VY
S
Y
R
L
T
G
LA
RS
A
N
A
QQ
K
GSEE
Q
RY
AI
AP
A--
F
T
WR
PDDK
T
NFT
----------
F
L
SYF
Q
N
E--
-
---
P
E
T
G
YY
G
W-
LP
KE
GT
VEPL
--
P
N
GK
-
-
-----RL
P
T
D
F
N
E
GAK
N
NTY
S
R
NEKMVGYS
F
D
H
E
FNDT
F
T
V
R
Q
N
L
R
F
A
E
N
K
T
S
Q
--
NS
V
YG
-
-
Y
GVCS
D
PANAY
S
KQ
--------
CAALAPADKGHYLA
R
KYVVD
D
EKL
Q
N
F
SV
D
T
Q
L
Q
S
K
F
A
TG
D
I
D
H
T
L
L
---------------
TGV
D
F
M
R
MR
N
DIN
A
W
--------------------
F
G
YD
DSV
P
LLN
-
LY
N
PVN
T
D
-
FDFNAKDPA
N
SG
P
YRIL----
N
KQK
QT
---G
V
Y
V
Q
D
QA
Q
WDKV
L
V
T
L
GG
-
-
--
-
-
--
RYD
W
A
D
Q
------------
ESLNRVAGT
T
D
-----
KRDD
K
QF
TW
R
G
G
VN
Y
-
L
F
DNG
V
T
P
Y
F
SY
S
E
SF
E
-----
P
---------
S
S
-QV
---
G
K
D
G
NI
-
FAP
S
KG
K
Q
YE
V
G
V
K
YVPE
D
R
PI
VV
T
G
A
V
YN
LTKT
N
NLM
--------
A
D
P
EG
S
F
FS
V
EG
G
EI
R
A
R
GVEIE
AK
---
A
A
LS
A
S
VN
V
V
G
S
YT
YTD
AE
YTTD
T
TY
K
GN
TP
AQ
--------
V
P
K
H
MAS
LW
A
D
Y
TFF
D
G
P
LS
G
LT
L
G
T
G
G
RY
T
G
--
S
S
Y---G
D
-
P
A
-
-
N
-S
F
KV
GSY
T
VVDA
LV
RY
D
L
A
R
VGMAG
S
N
V
A
L
H
VNNLFD
RE
YVAS
CFN
T
-
Y
-------
GCFW
GA
E
R
Q
F
VA
TAT
FR
F
fig|656414.3.peg.277
Escherichia coli H736
MAR
SKT
A
QPK
HSL
RKIAVV
V
A
T
AVS
G
MSVY
AQA
-
A
V
E
PK-
--
EDT
I
T
V
T
A
A
P
---
-
APQ
E
SA
WGPA
ATIAARQSAT
GTK
TDT
P
IQ
K
V
PQS
I
S
VV
T
A
E
E
M
A
LH
Q
PK
S
V
K
EAL
S
Y
TPGV
S
---
V
G
TR
G
A
S
N
T
Y
D
H
L
I
I
-
RGF
-
AAEG
Q
SQ
N
N
Y
L
N
G
L
KL
-------
Q
G
N
FYND
A
VI
D
PYML
ER
A
E
I
M
RGP
V
S
VL
YG
K
S
S
P
G
G
L
L
NMVSK
R
PT
T
EPL
K
-
E
V
QF
KA
G
T
DSLF
Q
TGF
D
FSDS
L
D
DDG
VY
S
Y
R
L
T
G
LA
RS
A
N
A
QQ
K
GSEE
Q
RY
AI
AP
A--
F
T
WR
PDDK
T
NFT
----------
F
L
SYF
Q
N
E--
-
---
P
E
T
G
YY
G
W-
LP
KE
GT
VEPL
--
P
N
GK
-
-
-----RL
P
T
D
F
N
E
GAK
N
NTY
S
R
NEKMVGYS
F
D
H
E
FNDT
F
T
V
R
Q
N
L
R
F
A
E
N
K
T
S
Q
--
NS
V
YG
-
-
Y
GVCS
D
PANAY
S
KQ
--------
CAALAPADKGHYLA
R
KYVVD
D
EKL
Q
N
F
SV
D
T
Q
L
Q
S
K
F
A
TG
D
I
D
H
T
L
L
---------------
I
GV
D
F
M
R
MR
N
DIN
A
W
--------------------
F
G
YD
DSV
P
LLN
-
LY
N
PVN
T
D
-
FDFNAKDPA
N
SG
P
YRIL----
N
KQK
QT
---G
V
Y
V
Q
D
QA
Q
WDKV
L
V
T
L
GG
-
-
--
-
-
--
RYD
W
A
D
Q
------------
ESLNRVAGT
T
D
-----
KRDD
K
QF
TW
R
G
G
VN
Y
-
L
F
DNG
V
T
P
Y
F
SY
S
E
SF
E
-----
P
---------
S
S
-QV
---
G
K
D
G
NI
-
FAP
S
KG
K
Q
YE
V
G
V
K
YVPE
D
R
PI
VV
T
G
A
V
YN
LTKT
N
NLM
--------
A
D
P
EG
S
F
FS
V
EG
G
EI
R
A
R
GVEIE
AK
---
A
A
LS
A
S
VN
V
V
G
S
YT
YTD
AE
YTTD
T
TY
K
GN
TP
AQ
--------
V
P
K
H
MAS
LW
A
D
Y
TFF
D
G
P
LS
G
LT
L
G
T
G
G
RY
T
G
--
S
S
Y---G
D
-
P
A
-
-
N
-S
F
KV
GSY
T
VVDA
LV
RY
D
L
A
R
VGMAG
S
N
V
A
L
H
VNNLFD
RE
YVAS
CFN
T
-
Y
-------
GCFW
GA
E
R
Q
V
VA
TAT
FR
F
fig|340186.3.peg.669
Escherichia coli E110019
MAR
SKT
A
QPK
HSL
RKIAVV
V
A
T
AVS
G
MSVY
AQA
-
A
V
E
PK-
--
EDT
I
T
V
T
A
A
P
---
-
APQ
E
SA
WGPA
ATIAARQSAT
GTK
TDT
P
IQ
K
V
PQS
I
S
VV
T
A
E
E
M
A
LH
Q
PK
S
V
K
EAL
S
Y
TPGV
S
---
V
G
TR
G
A
S
N
T
Y
D
H
L
I
I
-
RGF
-
AAEG
Q
SQ
N
N
Y
L
N
G
L
KL
-------
Q
G
N
FYND
A
VI
D
PYML
ER
A
E
I
M
RGP
V
S
VL
YG
K
S
S
P
G
G
L
L
NMVSK
R
PT
T
EPL
K
-
E
V
QF
KA
G
T
DSLF
Q
TGF
D
FSDS
L
D
DDG
VY
S
Y
R
L
T
G
LA
RS
A
N
A
QQ
K
GSEE
Q
RY
AI
AP
A--
F
T
WR
PDDK
T
NFT
----------
F
L
SYF
Q
N
E--
-
---
P
E
T
G
YY
G
W-
LP
KE
GT
VEPL
--
P
N
GK
-
-
-----RL
P
T
D
F
N
E
GAK
N
NTY
S
R
NEKMVGYS
F
D
H
E
FNDT
F
T
V
R
Q
N
L
R
F
A
E
N
K
T
S
Q
--
NS
V
YG
-
-
Y
GVCS
D
PANAY
S
KQ
--------
CAALAPADKGHYLA
R
KYVVD
D
EKL
Q
N
F
SV
D
T
Q
L
Q
S
K
F
A
TG
D
I
D
H
T
L
L
---------------
TGV
D
F
M
R
MR
N
DIN
A
W
--------------------
F
G
YD
DSV
P
LLN
-
LY
N
PVN
T
D
-
FDFNAKDPA
N
SG
P
YRIL----
N
KQK
QT
---G
V
Y
V
Q
D
QA
Q
WDKV
L
V
T
L
GG
-
-
--
-
-
--
RYD
W
A
D
Q
------------
ESLNRVAGT
T
D
-----
KRDD
K
QF
TW
R
G
G
VN
Y
-
L
F
DNG
V
T
P
Y
F
SY
S
E
SF
E
-----
P
---------
S
S
-QV
---
G
K
D
G
NI
-
FAP
S
KG
K
Q
YE
V
G
V
K
YVPE
D
R
PI
VV
T
G
A
V
YN
LTKT
N
NLM
--------
A
D
P
EG
S
F
FS
V
EG
G
EI
R
A
R
GVEIE
AK
---
A
A
LS
A
S
VN
V
V
G
S
YT
YTD
AE
YTTD
T
TY
K
GN
SP
AQ
--------
V
P
K
H
MAS
LW
A
G
Y
TFF
D
G
P
LS
G
LT
L
G
T
G
G
RY
T
G
--
S
S
Y---G
D
-
P
A
-
-
N
-S
F
KV
GSY
T
VVDA
LV
RY
D
L
A
R
VGMAG
S
N
V
A
L
H
VNNLFD
RE
YVAS
CFN
T
-
Y
-------
GCFW
GA
E
R
Q
V
VA
TAT
FR
F
fig|316385.5.peg.131
Escherichia coli str. K-12 substr. DH10B
MAR
SKT
A
QPK
HSL
RKIAVV
V
A
T
AVS
G
MSVY
AQA
-
A
V
E
PK-
--
EDT
I
T
V
T
A
A
P
---
-
APQ
E
SA
WGPA
ATIAARQSAT
GTK
TDT
P
IQ
K
V
PQS
I
S
VV
T
A
E
E
M
A
LH
Q
PK
S
V
K
EAL
S
Y
TPGV
S
---
V
G
TR
G
A
S
N
T
Y
D
H
L
I
I
-
RGF
-
AAEG
Q
SQ
N
N
Y
L
N
G
L
KL
-------
Q
G
N
FYND
A
VI
D
PYML
ER
A
E
I
M
RGP
V
S
VL
YG
K
S
S
P
G
G
L
L
NMVSK
R
PT
T
EPL
K
-
E
V
QF
KA
G
T
DSLF
Q
TGF
D
FSDS
L
D
DDG
VY
S
Y
R
L
T
G
LA
RS
A
N
A
QQ
K
GSEE
Q
RY
AI
AP
A--
F
T
X
R
PDDK
T
NFT
----------
F
L
SYF
Q
N
E--
-
---
P
E
T
G
YY
G
W-
LP
KE
GT
VEPL
--
P
N
GK
-
-
-----RL
P
T
D
F
N
E
GAK
N
NTY
S
R
NEKMVGYS
F
D
H
E
FNDT
F
T
V
R
Q
N
L
R
F
A
E
N
K
T
S
Q
--
NS
V
YG
-
-
Y
GVCS
D
PANAY
S
KQ
--------
CAALAPADKGHYLA
R
KYVVD
D
EKL
Q
N
F
SV
D
T
Q
L
Q
S
K
F
A
TG
D
I
D
H
T
L
L
---------------
TGV
D
F
M
R
MR
N
DIN
A
W
--------------------
F
G
YD
DSV
P
LLN
-
LY
N
PVN
T
D
-
FDFNAKDPA
N
SG
P
YRIL----
N
KQK
QT
---G
V
Y
V
Q
D
QA
Q
WDKV
L
V
T
L
GG
-
-
--
-
-
--
RYD
W
A
D
Q
------------
ESLNRVAGT
T
D
-----
KRDD
K
QF
TW
R
G
G
VN
Y
-
L
F
DNG
V
T
P
Y
F
SY
S
E
SF
E
-----
P
---------
S
S
-QV
---
G
K
D
G
NI
-
FAP
S
KG
K
Q
YE
V
G
V
K
YVPE
D
R
PI
VV
T
G
A
V
YN
LTKT
N
NLM
--------
A
D
P
EG
S
F
FS
V
EG
G
EI
R
A
R
GVEIE
AK
---
A
A
LS
A
S
VN
V
V
G
S
YT
YTD
AE
YTTD
T
TY
K
GN
TP
AQ
--------
V
P
K
H
MAS
LW
A
D
Y
TFF
D
G
P
LS
G
LT
L
G
T
G
G
RY
T
G
--
S
S
Y---G
D
-
P
A
-
-
N
-S
F
KV
GSY
T
VVDA
LV
RY
D
L
A
R
VGMAG
S
N
V
A
L
H
VNNLFD
RE
YVAS
CFN
T
-
Y
-------
GCFW
GA
E
R
Q
V
VA
TAT
FR
F
fig|316385.7.peg.133
Escherichia coli str. K-12 substr. DH10B
MAR
SKT
A
QPK
HSL
RKIAVV
V
A
T
AVS
G
MSVY
AQA
-
A
V
E
PK-
--
EDT
I
T
V
T
A
A
P
---
-
APQ
E
SA
WGPA
ATIAARQSAT
GTK
TDT
P
IQ
K
V
PQS
I
S
VV
T
A
E
E
M
A
LH
Q
PK
S
V
K
EAL
S
Y
TPGV
S
---
V
G
TR
G
A
S
N
T
Y
D
H
L
I
I
-
RGF
-
AAEG
Q
SQ
N
N
Y
L
N
G
L
KL
-------
Q
G
N
FYND
A
VI
D
PYML
ER
A
E
I
M
RGP
V
S
VL
YG
K
S
S
P
G
G
L
L
NMVSK
R
PT
T
EPL
K
-
E
V
QF
KA
G
T
DSLF
Q
TGF
D
FSDS
L
D
DDG
VY
S
Y
R
L
T
G
LA
RS
A
N
A
QQ
K
GSEE
Q
RY
AI
AP
A--
F
T
X
R
PDDK
T
NFT
----------
F
L
SYF
Q
N
E--
-
---
P
E
T
G
YY
G
W-
LP
KE
GT
VEPL
--
P
N
GK
-
-
-----RL
P
T
D
F
N
E
GAK
N
NTY
S
R
NEKMVGYS
F
D
H
E
FNDT
F
T
V
R
Q
N
L
R
F
A
E
N
K
T
S
Q
--
NS
V
YG
-
-
Y
GVCS
D
PANAY
S
KQ
--------
CAALAPADKGHYLA
R
KYVVD
D
EKL
Q
N
F
SV
D
T
Q
L
Q
S
K
F
A
TG
D
I
D
H
T
L
L
---------------
TGV
D
F
M
R
MR
N
DIN
A
W
--------------------
F
G
YD
DSV
P
LLN
-
LY
N
PVN
T
D
-
FDFNAKDPA
N
SG
P
YRIL----
N
KQK
QT
---G
V
Y
V
Q
D
QA
Q
WDKV
L
V
T
L
GG
-
-
--
-
-
--
RYD
W
A
D
Q
------------
ESLNRVAGT
T
D
-----
KRDD
K
QF
TW
R
G
G
VN
Y
-
L
F
DNG
V
T
P
Y
F
SY
S
E
SF
E
-----
P
---------
S
S
-QV
---
G
K
D
G
NI
-
FAP
S
KG
K
Q
YE
V
G
V
K
YVPE
D
R
PI
VV
T
G
A
V
YN
LTKT
N
NLM
--------
A
D
P
EG
S
F
FS
V
EG
G
EI
R
A
R
GVEIE
AK
---
A
A
LS
A
S
VN
V
V
G
S
YT
YTD
AE
YTTD
T
TY
K
GN
TP
AQ
--------
V
P
K
H
MAS
LW
A
D
Y
TFF
D
G
P
LS
G
LT
L
G
T
G
G
RY
T
G
--
S
S
Y---G
D
-
P
A
-
-
N
-S
F
KV
GSY
T
VVDA
LV
RY
D
L
A
R
VGMAG
S
N
V
A
L
H
VNNLFD
RE
YVAS
CFN
T
-
Y
-------
GCFW
GA
E
R
Q
V
VA
TAT
FR
F
fig|749538.3.peg.3110
Escherichia coli MS 116-1
MAR
SKT
A
QPK
HSL
RKIAVV
V
A
T
AVS
G
MSVY
AQA
-
A
V
E
PK-
--
EDT
I
T
V
T
A
A
P
---
-
A
S
Q
E
SA
WGPA
ATIAARQSAT
GTK
TDT
P
IQ
K
V
PQS
I
S
VV
T
A
E
E
M
A
LH
Q
PK
S
V
K
EAL
S
Y
TPGV
S
---
V
G
TR
G
A
S
N
T
Y
D
H
L
I
I
-
RGF
-
AAEG
Q
SQ
N
N
Y
L
N
G
L
KL
-------
Q
G
N
FYND
A
VI
D
PYML
ER
A
E
I
M
RGP
V
S
VL
YG
K
S
S
P
G
G
L
L
NMVSK
R
PT
T
EPL
K
-
E
V
QF
KA
G
T
DSLF
Q
TGF
D
FSDS
L
D
DDG
VY
S
Y
R
L
T
G
LA
RS
A
N
A
QQ
K
GSEE
Q
RY
AI
A
S
A--
F
T
WR
PDDK
T
NFT
----------
F
L
SYF
Q
N
E--
-
---
P
E
T
G
YY
G
W-
LP
KE
GT
VEPL
--
P
N
GK
-
-
-----RL
P
T
D
F
N
E
GAK
N
NTY
S
R
NEKMVGYS
F
D
H
E
FNDT
F
T
V
R
Q
N
L
R
F
A
E
N
K
T
S
Q
--
NS
V
YG
-
-
Y
GVCS
D
PANAY
S
KQ
--------
CAALAPADKGHYLA
R
KYVVD
D
EKL
Q
N
F
SV
D
T
Q
L
Q
S
K
F
A
TG
D
I
D
H
T
L
L
---------------
TGV
D
F
M
R
MR
N
DIN
A
W
--------------------
F
G
YD
DSV
P
LLN
-
LY
N
PVN
T
D
-
FDFNAKDPA
N
SG
P
YRIL----
N
KQK
QT
---G
V
Y
V
Q
D
QA
Q
WDKV
L
V
T
L
GG
-
-
--
-
-
--
RYD
W
A
D
Q
------------
ESLNRVAGT
T
D
-----
KRDD
K
QF
TW
R
G
G
VN
Y
-
L
F
DNG
V
T
P
Y
F
SY
S
E
SF
E
-----
P
---------
S
S
-QV
---
G
K
D
G
NI
-
FAP
S
KG
K
Q
YE
V
G
V
K
YVPE
D
R
PI
VV
T
G
A
V
YN
LTKT
N
NLM
--------
A
D
P
EG
S
F
FS
V
EG
G
EI
R
A
R
GVEIE
AK
---
A
A
LS
A
S
VN
V
V
G
S
YT
YTD
AE
YTTD
T
TY
K
GN
TP
AQ
--------
V
P
K
H
MAS
LW
A
D
Y
TFF
D
G
P
LS
G
LT
L
G
T
G
G
RY
T
G
--
S
S
Y---G
D
-
P
A
-
-
N
-S
F
KV
GSY
T
VVDA
LV
RY
D
L
A
R
VGMAG
S
N
V
A
L
H
VNNLFD
RE
YVAS
CFN
T
-
Y
-------
GCFW
GA
E
R
Q
V
VA
TAT
FR
F
fig|216592.1.peg.4255
Escherichia coli 042
MAR
SKT
A
QPK
HSL
RKIAVV
V
A
T
AVS
G
MSVY
AQA
-
A
V
E
PK-
--
EDT
I
T
V
T
A
A
P
---
-
APQ
E
SA
WGPA
ATIAARQSAT
GTK
TDT
P
IQ
K
V
PQS
I
S
VV
T
A
E
E
M
A
LH
Q
PK
S
V
K
EAL
S
Y
TPGV
A
---
V
G
TR
G
A
S
N
T
Y
D
Y
L
I
I
-
RGF
-
AADG
Q
SQ
N
N
Y
L
N
G
L
KM
-------
Q
G
N
FYND
A
VI
D
PYML
ER
A
E
I
M
RGP
V
S
VL
YG
K
S
S
P
G
G
L
L
NMVSK
R
PT
T
EPL
K
-
E
V
QF
KA
G
T
DSLF
Q
TGF
D
FSDA
L
D
DDG
VY
S
Y
R
L
T
G
LA
RS
A
N
A
QQ
K
GAEE
Q
RY
AI
AP
A--
F
T
WR
PDDK
T
NFT
----------
F
L
SYF
Q
N
E--
-
---
P
E
T
G
YY
G
W-
LP
KE
GT
VEPL
--
P
N
GK
-
-
-----RL
P
T
D
F
N
E
GAK
N
NTY
S
R
NEKM
I
GYS
F
D
H
E
FNDT
F
T
V
R
Q
N
L
R
F
A
Q
N
K
V
S
Q
--
KS
V
YG
-
-
Y
GMCS
D
P--LY
S
SN
P
---
SSSP
CANVPQSQWGHTLT
R
QYVID
N
EKL
E
N
F
SV
D
T
Q
L
Q
S
K
F
A
TG
S
V
D
H
T
L
L
---------------
TGV
D
F
M
R
MR
N
DID
S
W
--------------------
F
G
YA
G
SV
A
PSD
-
IY
N
LDR
S
D
-
FDFGAH-PN
P
SG
P
YRVL----
L
KQK
QT
---G
LY
V
Q
D
QA
Q
WDKV
L
V
T
L
GG
-
-
--
-
-
--
RYD
W
A
D
Q
------------
SSFNRDYGN
K
S
-----
DRDD
K
QF
TW
R
G
G
VN
Y
-
L
F
DNG
V
T
P
Y
F
SY
S
E
SF
E
-----
P
---------
A
S
-QT
---
D
A
N
G
DL
-
FAP
S
KG
K
Q
YE
V
G
V
K
YVPE
D
R
PI
VV
T
G
AL
Y
Q
LTKT
N
NLM
--------
A
D
P
N
G
S
L
FS
V
EG
G
EI
R
A
R
GVE
L
E
AK
---
A
A
LS
A
S
VNL
V
G
S
YT
YTD
AE
YTTD
T
TY
K
GN
TP
AQ
--------
V
P
K
H
MAS
LW
A
D
Y
TFF
D
G
P
LS
G
LT
L
G
T
G
G
RY
T
G
--
S
S
Y---G
D
-
P
A
-
-
N
-S
F
KV
GSY
T
VVDA
LV
RY
D
L
A
R
VGMAG
S
N
V
A
L
H
VNNLFD
RE
YVAS
CFN
T
-
Y
-------
GCFW
GA
E
R
Q
V
VA
TAT
FR
F
fig|585057.4.peg.168
Escherichia coli IAI39
MAR
SKT
A
QPK
HSL
RKIAVV
V
A
T
AVS
G
MSVY
AQA
-
A
V
E
PK-
--
EDT
I
T
V
T
A
A
P
---
-
APQ
E
SA
WGPA
ATIAARQSAT
GTK
TDT
P
IQ
K
V
PQS
I
S
VV
T
A
E
E
M
A
LH
Q
PK
S
V
K
EAL
S
Y
TPGV
A
---
V
G
TR
G
A
S
N
T
Y
D
Y
L
I
I
-
RGF
-
AADG
Q
SQ
N
N
Y
L
N
G
L
KM
-------
Q
G
N
FYND
A
VI
D
PYML
ER
A
E
I
M
RGP
V
S
VL
YG
K
S
S
P
G
G
L
L
NMVSK
R
PT
T
EPL
K
-
E
V
QF
KA
G
T
DSLF
Q
TGF
D
FSDA
L
D
DDG
VY
S
Y
R
L
T
G
LA
RS
A
N
A
QQ
K
GAEE
Q
RY
AI
AP
A--
F
T
WR
PDDK
T
NFT
----------
F
L
SYF
Q
N
E--
-
---
P
E
T
G
YY
G
W-
LP
KE
GT
VEPL
--
P
N
GK
-
-
-----RL
P
T
D
F
N
E
GAK
N
NTY
S
R
NEKM
I
GYS
F
D
H
E
FNDT
F
T
V
R
Q
N
L
R
F
A
Q
N
K
V
S
Q
--
KS
V
YG
-
-
Y
GMCS
D
P--LY
S
SN
P
---
SSSP
CANVPQSQWGHTLT
R
QYVID
N
EKL
E
N
F
SV
D
T
Q
L
Q
S
K
F
A
TG
S
V
D
H
T
L
L
---------------
TGV
D
F
M
R
MR
N
DID
S
W
--------------------
F
G
YA
G
SV
A
PSD
-
IY
N
LDR
S
D
-
FDFGAH-PN
P
SG
P
YRVL----
L
KQK
QT
---G
LY
V
Q
D
QA
Q
WDKV
L
V
T
L
GG
-
-
--
-
-
--
RYD
W
A
D
Q
------------
SSFNRDYGN
K
S
-----
DRDD
K
QF
TW
R
G
G
VN
Y
-
L
F
DNG
V
T
P
Y
F
SY
S
E
SF
E
-----
P
---------
A
S
-QT
---
D
A
N
G
DL
-
FAP
S
KG
K
Q
YE
V
G
V
K
YVPE
D
R
PI
VV
T
G
AL
Y
Q
LTKT
N
NLM
--------
A
D
P
N
G
S
L
FS
V
EG
G
EI
R
A
R
GVE
L
E
AK
---
A
A
LS
A
S
VNL
V
G
S
YT
YTD
AE
YTTD
T
TY
K
GN
TP
AQ
--------
V
P
K
H
MAS
LW
A
D
Y
TFF
D
G
P
LS
G
LT
L
G
T
G
G
RY
T
G
--
S
S
Y---G
D
-
P
A
-
-
N
-S
F
KV
GSY
T
VVDA
LV
RY
D
L
A
R
VGMAG
S
N
V
A
L
H
VNNLFD
RE
YVAS
CFN
T
-
Y
-------
GCFW
GA
E
R
Q
V
VA
TAT
FR
F
fig|656417.3.peg.254
Escherichia coli M605
MAR
SKT
A
QPK
HSL
RKIAVV
V
A
T
AVS
G
MSVY
AQA
-
A
V
E
PK-
--
EDT
I
T
V
T
A
A
P
---
-
APQ
E
SA
WGPA
ATIAARQSAT
GTK
TDT
P
IQ
K
V
PQS
I
S
VV
T
A
E
E
M
A
LH
Q
PK
S
V
K
EAL
S
Y
TPGV
A
---
V
G
TR
G
A
S
N
T
Y
D
Y
L
I
I
-
RGF
-
AADG
Q
SQ
N
N
Y
L
N
G
L
KM
-------
Q
G
N
FYND
A
VI
D
PYML
ER
A
E
I
M
RGP
V
S
VL
YG
K
S
S
P
G
G
L
L
NMVSK
R
PT
T
EPL
K
-
E
V
QF
KA
G
T
DSLF
Q
TGF
D
FSDA
L
D
DDG
VY
S
Y
R
L
T
G
LA
RS
A
N
A
QQ
K
GSEE
Q
RY
AI
AP
A--
F
T
WR
PDDK
T
NFT
----------
F
L
SYF
Q
N
E--
-
---
P
E
T
G
YY
G
W-
LP
KE
GT
VEPL
--
P
N
GK
-
-
-----RL
P
T
D
F
N
E
GAK
N
NTY
S
R
NEKM
I
GYS
F
D
H
E
FNDT
F
T
V
R
Q
N
L
R
F
A
Q
N
K
V
S
Q
--
KS
V
YG
-
-
Y
GMCS
D
P--LY
S
SN
P
---
SSSP
CANVPQSQWGHTLT
R
QYVID
N
EKL
E
N
F
SV
D
T
Q
L
Q
S
K
F
A
TG
S
V
D
H
T
L
L
---------------
TGV
D
F
M
R
MR
N
DID
S
W
--------------------
F
G
YA
G
SV
A
PSD
-
IY
N
LDR
S
D
-
FDFGAH-PN
P
SG
P
YRVL----
L
KQK
QT
---G
LY
V
Q
D
QA
Q
WDKV
L
V
T
L
GG
-
-
--
-
-
--
RYD
W
A
D
Q
------------
SSFNRDYGN
K
S
-----
ERDD
K
EF
TW
R
G
G
VN
Y
-
L
F
DNG
V
T
P
Y
F
SY
S
E
SF
E
-----
P
---------
A
S
-QT
---
D
A
N
G
DL
-
FAP
S
KG
K
Q
YE
V
G
V
K
YVPE
D
R
PI
VV
T
G
AL
Y
Q
LTKT
N
NLM
--------
A
D
P
N
G
S
L
FS
V
EG
G
EI
R
A
R
GVE
L
E
AK
---
A
A
LS
A
S
VNL
V
G
S
YT
YTD
AE
YTTD
T
NY
K
GN
TP
AQ
--------
V
P
K
H
MAS
LW
A
D
Y
TFF
D
G
P
LS
G
LT
L
G
T
G
G
RY
T
G
--
S
S
Y---G
D
-
P
A
-
-
N
-S
F
KV
GSY
T
VVDA
LV
RY
D
L
A
R
VGMAG
S
N
V
A
L
H
VNNLFD
RE
YVAS
CFN
T
-
Y
-------
GCFW
GA
E
R
Q
V
VA
TAT
FR
F
fig|525281.3.peg.1111
Escherichia coli 83972
MA
PSKT
A
QPK
HSL
RKIAVV
V
A
T
AVS
G
MSVY
AQA
-
A
V
E
PK-
--
EDT
I
T
V
T
A
A
P
---
-
APQ
E
SA
WGPA
ATIAARQSAT
GTK
TDT
P
IQ
K
V
PQS
I
S
VV
T
A
E
E
M
A
LH
Q
PK
S
V
K
EAL
S
Y
TPGV
A
---
V
G
TR
G
A
S
N
T
Y
D
Y
L
I
I
-
RGF
-
AADG
Q
SQ
N
N
Y
L
N
G
L
KL
-------
Q
G
N
FYND
A
VI
D
PYML
ER
A
E
I
M
RGP
V
S
VL
YG
K
S
S
P
G
G
L
L
NMVSK
R
PT
T
EPL
K
-
E
V
QF
KA
G
T
DSLF
Q
TGF
D
FSDA
L
D
DDG
VY
S
Y
R
L
T
G
LA
RS
A
N
A
QQ
K
GSEE
Q
RY
AI
AP
A--
F
T
WR
PDDK
T
NFT
----------
F
L
SYF
Q
N
E--
-
---
P
E
T
G
YY
G
W-
LP
KE
GT
VEPL
--
P
N
GK
-
-
-----RL
P
T
D
F
N
E
GAK
N
NTY
S
R
NEKM
I
GYS
F
D
H
E
FNDT
F
T
V
R
Q
N
L
R
F
A
Q
N
K
V
S
Q
--
KS
V
YG
-
-
Y
GMCS
D
P--LY
T
KD
QEALKASP
CLSIPQSQWGHTLT
R
QYVID
N
EKL
E
N
F
SV
D
T
Q
L
Q
S
K
F
A
TG
S
V
D
H
T
L
L
---------------
TGV
D
F
M
R
MR
N
DID
S
W
--------------------
F
G
YA
G
SV
A
PSD
-
IY
N
LDR
S
D
-
FDFGAH-PN
P
SG
P
YRVL----
L
KQK
QT
---G
LY
V
Q
D
QA
Q
WDKV
L
V
T
L
GG
-
-
--
-
-
--
RYD
W
A
D
Q
------------
SSFNRDYGN
K
S
-----
ERDD
K
EF
TW
R
G
G
VN
Y
-
L
F
DNG
V
T
P
Y
F
SY
S
E
SF
E
-----
P
---------
A
S
-QT
---
D
A
N
G
DL
-
FAP
S
KG
K
Q
YE
V
G
V
K
YVPE
D
R
PI
VV
T
G
AL
Y
Q
LTKT
N
NLM
--------
A
D
P
N
G
S
L
FS
V
EG
G
EI
R
A
R
GVE
L
E
AK
---
A
A
LS
A
S
VN
V
V
G
S
YT
YTD
AE
YTTD
T
TY
K
GN
TP
AQ
--------
V
P
K
H
MAS
LW
A
D
Y
TFF
D
G
P
LS
G
LT
L
G
T
G
G
RY
T
G
--
S
S
Y---G
D
-
P
A
-
-
N
-S
F
KV
GSY
T
VVDA
LV
RY
D
L
A
R
VGMAG
S
N
V
A
L
H
VNNLFD
RE
YVAS
CFN
T
-
Y
-------
GCFW
GA
E
R
Q
V
VA
TAT
FR
F
fig|655817.3.peg.178
Escherichia coli ABU 83972
MA
PSKT
A
QPK
HSL
RKIAVV
V
A
T
AVS
G
MSVY
AQA
-
A
V
E
PK-
--
EDT
I
T
V
T
A
A
P
---
-
APQ
E
SA
WGPA
ATIAARQSAT
GTK
TDT
P
IQ
K
V
PQS
I
S
VV
T
A
E
E
M
A
LH
Q
PK
S
V
K
EAL
S
Y
TPGV
A
---
V
G
TR
G
A
S
N
T
Y
D
Y
L
I
I
-
RGF
-
AADG
Q
SQ
N
N
Y
L
N
G
L
KL
-------
Q
G
N
FYND
A
VI
D
PYML
ER
A
E
I
M
RGP
V
S
VL
YG
K
S
S
P
G
G
L
L
NMVSK
R
PT
T
EPL
K
-
E
V
QF
KA
G
T
DSLF
Q
TGF
D
FSDA
L
D
DDG
VY
S
Y
R
L
T
G
LA
RS
A
N
A
QQ
K
GSEE
Q
RY
AI
AP
A--
F
T
WR
PDDK
T
NFT
----------
F
L
SYF
Q
N
E--
-
---
P
E
T
G
YY
G
W-
LP
KE
GT
VEPL
--
P
N
GK
-
-
-----RL
P
T
D
F
N
E
GAK
N
NTY
S
R
NEKM
I
GYS
F
D
H
E
FNDT
F
T
V
R
Q
N
L
R
F
A
Q
N
K
V
S
Q
--
KS
V
YG
-
-
Y
GMCS
D
P--LY
T
KD
QEALKASP
CLSIPQSQWGHTLT
R
QYVID
N
EKL
E
N
F
SV
D
T
Q
L
Q
S
K
F
A
TG
S
V
D
H
T
L
L
---------------
TGV
D
F
M
R
MR
N
DID
S
W
--------------------
F
G
YA
G
SV
A
PSD
-
IY
N
LDR
S
D
-
FDFGAH-PN
P
SG
P
YRVL----
L
KQK
QT
---G
LY
V
Q
D
QA
Q
WDKV
L
V
T
L
GG
-
-
--
-
-
--
RYD
W
A
D
Q
------------
SSFNRDYGN
K
S
-----
ERDD
K
EF
TW
R
G
G
VN
Y
-
L
F
DNG
V
T
P
Y
F
SY
S
E
SF
E
-----
P
---------
A
S
-QT
---
D
A
N
G
DL
-
FAP
S
KG
K
Q
YE
V
G
V
K
YVPE
D
R
PI
VV
T
G
AL
Y
Q
LTKT
N
NLM
--------
A
D
P
N
G
S
L
FS
V
EG
G
EI
R
A
R
GVE
L
E
AK
---
A
A
LS
A
S
VN
V
V
G
S
YT
YTD
AE
YTTD
T
TY
K
GN
TP
AQ
--------
V
P
K
H
MAS
LW
A
D
Y
TFF
D
G
P
LS
G
LT
L
G
T
G
G
RY
T
G
--
S
S
Y---G
D
-
P
A
-
-
N
-S
F
KV
GSY
T
VVDA
LV
RY
D
L
A
R
VGMAG
S
N
V
A
L
H
VNNLFD
RE
YVAS
CFN
T
-
Y
-------
GCFW
GA
E
R
Q
V
VA
TAT
FR
F
fig|199310.1.peg.179
Escherichia coli CFT073
MA
PSKT
A
QPK
HSL
RKIAVV
V
A
T
AVS
G
MSVY
AQA
-
A
V
E
PK-
--
EDT
I
T
V
T
A
A
P
---
-
APQ
E
SA
WGPA
ATIAARQSAT
GTK
TDT
P
IQ
K
V
PQS
I
S
VV
T
A
E
E
M
A
LH
Q
PK
S
V
K
EAL
S
Y
TPGV
A
---
V
G
TR
G
A
S
N
T
Y
D
Y
L
I
I
-
RGF
-
AADG
Q
SQ
N
N
Y
L
N
G
L
KL
-------
Q
G
N
FYND
A
VI
D
PYML
ER
A
E
I
M
RGP
V
S
VL
YG
K
S
S
P
G
G
L
L
NMVSK
R
PT
T
EPL
K
-
E
V
QF
KA
G
T
DSLF
Q
TGF
D
FSDA
L
D
DDG
VY
S
Y
R
L
T
G
LA
RS
A
N
A
QQ
K
GSEE
Q
RY
AI
AP
A--
F
T
WR
PDDK
T
NFT
----------
F
L
SYF
Q
N
E--
-
---
P
E
T
G
YY
G
W-
LP
KE
GT
VEPL
--
P
N
GK
-
-
-----RL
P
T
D
F
N
E
GAK
N
NTY
S
R
NEKM
I
GYS
F
D
H
E
FNDT
F
T
V
R
Q
N
L
R
F
A
Q
N
K
V
S
Q
--
KS
V
YG
-
-
Y
GMCS
D
P--LY
T
KD
QEALKASP
CLSIPQSQWGHTLT
R
QYVID
N
EKL
E
N
F
SV
D
T
Q
L
Q
S
K
F
A
TG
S
V
D
H
T
L
L
---------------
TGV
D
F
M
R
MR
N
DID
S
W
--------------------
F
G
YA
G
SV
A
PSD
-
IY
N
LDR
S
D
-
FDFGAH-PN
P
SG
P
YRVL----
L
KQK
QT
---G
LY
V
Q
D
QA
Q
WDKV
L
V
T
L
GG
-
-
--
-
-
--
RYD
W
A
D
Q
------------
SSFNRDYGN
K
S
-----
ERDD
K
EF
TW
R
G
G
VN
Y
-
L
F
DNG
V
T
P
Y
F
SY
S
E
SF
E
-----
P
---------
A
S
-QT
---
D
A
N
G
DL
-
FAP
S
KG
K
Q
YE
V
G
V
K
YVPE
D
R
PI
VV
T
G
AL
Y
Q
LTKT
N
NLM
--------
A
D
P
N
G
S
L
FS
V
EG
G
EI
R
A
R
GVE
L
E
AK
---
A
A
LS
A
S
VN
V
V
G
S
YT
YTD
AE
YTTD
T
TY
K
GN
TP
AQ
--------
V
P
K
H
MAS
LW
A
D
Y
TFF
D
G
P
LS
G
LT
L
G
T
G
G
RY
T
G
--
S
S
Y---G
D
-
P
A
-
-
N
-S
F
KV
GSY
T
VVDA
LV
RY
D
L
A
R
VGMAG
S
N
V
A
L
H
VNNLFD
RE
YVAS
CFN
T
-
Y
-------
GCFW
GA
E
R
Q
V
VA
TAT
FR
F
fig|199310.4.peg.174
Escherichia coli CFT073
MA
PSKT
A
QPK
HSL
RKIAVV
V
A
T
AVS
G
MSVY
AQA
-
A
V
E
PK-
--
EDT
I
T
V
T
A
A
P
---
-
APQ
E
SA
WGPA
ATIAARQSAT
GTK
TDT
P
IQ
K
V
PQS
I
S
VV
T
A
E
E
M
A
LH
Q
PK
S
V
K
EAL
S
Y
TPGV
A
---
V
G
TR
G
A
S
N
T
Y
D
Y
L
I
I
-
RGF
-
AADG
Q
SQ
N
N
Y
L
N
G
L
KL
-------
Q
G
N
FYND
A
VI
D
PYML
ER
A
E
I
M
RGP
V
S
VL
YG
K
S
S
P
G
G
L
L
NMVSK
R
PT
T
EPL
K
-
E
V
QF
KA
G
T
DSLF
Q
TGF
D
FSDA
L
D
DDG
VY
S
Y
R
L
T
G
LA
RS
A
N
A
QQ
K
GSEE
Q
RY
AI
AP
A--
F
T
WR
PDDK
T
NFT
----------
F
L
SYF
Q
N
E--
-
---
P
E
T
G
YY
G
W-
LP
KE
GT
VEPL
--
P
N
GK
-
-
-----RL
P
T
D
F
N
E
GAK
N
NTY
S
R
NEKM
I
GYS
F
D
H
E
FNDT
F
T
V
R
Q
N
L
R
F
A
Q
N
K
V
S
Q
--
KS
V
YG
-
-
Y
GMCS
D
P--LY
T
KD
QEALKASP
CLSIPQSQWGHTLT
R
QYVID
N
EKL
E
N
F
SV
D
T
Q
L
Q
S
K
F
A
TG
S
V
D
H
T
L
L
---------------
TGV
D
F
M
R
MR
N
DID
S
W
--------------------
F
G
YA
G
SV
A
PSD
-
IY
N
LDR
S
D
-
FDFGAH-PN
P
SG
P
YRVL----
L
KQK
QT
---G
LY
V
Q
D
QA
Q
WDKV
L
V
T
L
GG
-
-
--
-
-
--
RYD
W
A
D
Q
------------
SSFNRDYGN
K
S
-----
ERDD
K
EF
TW
R
G
G
VN
Y
-
L
F
DNG
V
T
P
Y
F
SY
S
E
SF
E
-----
P
---------
A
S
-QT
---
D
A
N
G
DL
-
FAP
S
KG
K
Q
YE
V
G
V
K
YVPE
D
R
PI
VV
T
G
AL
Y
Q
LTKT
N
NLM
--------
A
D
P
N
G
S
L
FS
V
EG
G
EI
R
A
R
GVE
L
E
AK
---
A
A
LS
A
S
VN
V
V
G
S
YT
YTD
AE
YTTD
T
TY
K
GN
TP
AQ
--------
V
P
K
H
MAS
LW
A
D
Y
TFF
D
G
P
LS
G
LT
L
G
T
G
G
RY
T
G
--
S
S
Y---G
D
-
P
A
-
-
N
-S
F
KV
GSY
T
VVDA
LV
RY
D
L
A
R
VGMAG
S
N
V
A
L
H
VNNLFD
RE
YVAS
CFN
T
-
Y
-------
GCFW
GA
E
R
Q
V
VA
TAT
FR
F
fig|585397.7.peg.161
Escherichia coli ED1a
MA
PSKT
A
QPK
HSL
RKIAVV
V
A
T
AVS
G
MSVY
AQA
-
A
V
E
PK-
--
EDT
I
T
V
T
A
A
P
---
-
APQ
E
SA
WGPA
ATIAARQSAT
GTK
TDT
P
IQ
K
V
PQS
I
S
VV
T
A
E
E
M
A
LH
Q
PK
S
V
K
EAL
S
Y
TPGV
A
---
V
G
TR
G
A
S
N
T
Y
D
Y
L
I
I
-
RGF
-
AADG
Q
SQ
N
N
Y
L
N
G
L
KL
-------
Q
G
N
FYND
A
VI
D
PYML
ER
A
E
I
M
RGP
V
S
VL
YG
K
S
S
P
G
G
L
L
NMVSK
R
PT
T
EPL
K
-
E
V
QF
KA
G
T
DSLF
Q
TGF
D
FSDA
L
D
DDG
VY
S
Y
R
L
T
G
LA
RS
A
N
A
QQ
K
GSEE
Q
RY
AI
AP
A--
F
T
WR
PDDK
T
NFT
----------
F
L
SYF
Q
N
E--
-
---
P
E
T
G
YY
G
W-
LP
KE
GT
VEPL
--
P
N
GK
-
-
-----RL
P
T
D
F
N
E
GAK
N
NTY
S
R
NEKM
I
GYS
F
D
H
E
FNDT
F
T
V
R
Q
N
L
R
F
A
Q
N
K
V
S
Q
--
KS
V
YG
-
-
Y
GMCS
D
P--LY
T
KD
QEALKASP
CLSIPQSQWGHTLT
R
QYVID
N
EKL
E
N
F
SV
D
T
Q
L
Q
S
K
F
A
TG
S
V
D
H
T
L
L
---------------
TGV
D
F
M
R
MR
N
DID
S
W
--------------------
F
G
YA
G
SV
A
PSD
-
IY
N
LDR
S
D
-
FDFGAH-PN
P
SG
P
YRVL----
L
KQK
QT
---G
LY
V
Q
D
QA
Q
WDKV
L
V
T
L
GG
-
-
--
-
-
--
RYD
W
A
D
Q
------------
SSFNRDYGN
K
S
-----
ERDD
K
EF
TW
R
G
G
VN
Y
-
L
F
DNG
V
T
P
Y
F
SY
S
E
SF
E
-----
P
---------
A
S
-QT
---
D
A
N
G
DL
-
FAP
S
KG
K
Q
YE
V
G
V
K
YVPE
D
R
PI
VV
T
G
AL
Y
Q
LTKT
N
NLM
--------
A
D
P
N
G
S
L
FS
V
EG
G
EI
R
A
R
GVE
L
E
AK
---
A
A
LS
A
S
VN
V
V
G
S
YT
YTD
AE
YTTD
T
TY
K
GN
TP
AQ
--------
V
P
K
H
MAS
LW
A
D
Y
TFF
D
G
P
LS
G
LT
L
G
T
G
G
RY
T
G
--
S
S
Y---G
D
-
P
A
-
-
N
-S
F
KV
GSY
T
VVDA
LV
RY
D
L
A
R
VGMAG
S
N
V
A
L
H
VNNLFD
RE
YVAS
CFN
T
-
Y
-------
GCFW
GA
E
R
Q
V
VA
TAT
FR
F
fig|585397.9.peg.161
Escherichia coli ED1a
MA
PSKT
A
QPK
HSL
RKIAVV
V
A
T
AVS
G
MSVY
AQA
-
A
V
E
PK-
--
EDT
I
T
V
T
A
A
P
---
-
APQ
E
SA
WGPA
ATIAARQSAT
GTK
TDT
P
IQ
K
V
PQS
I
S
VV
T
A
E
E
M
A
LH
Q
PK
S
V
K
EAL
S
Y
TPGV
A
---
V
G
TR
G
A
S
N
T
Y
D
Y
L
I
I
-
RGF
-
AADG
Q
SQ
N
N
Y
L
N
G
L
KL
-------
Q
G
N
FYND
A
VI
D
PYML
ER
A
E
I
M
RGP
V
S
VL
YG
K
S
S
P
G
G
L
L
NMVSK
R
PT
T
EPL
K
-
E
V
QF
KA
G
T
DSLF
Q
TGF
D
FSDA
L
D
DDG
VY
S
Y
R
L
T
G
LA
RS
A
N
A
QQ
K
GSEE
Q
RY
AI
AP
A--
F
T
WR
PDDK
T
NFT
----------
F
L
SYF
Q
N
E--
-
---
P
E
T
G
YY
G
W-
LP
KE
GT
VEPL
--
P
N
GK
-
-
-----RL
P
T
D
F
N
E
GAK
N
NTY
S
R
NEKM
I
GYS
F
D
H
E
FNDT
F
T
V
R
Q
N
L
R
F
A
Q
N
K
V
S
Q
--
KS
V
YG
-
-
Y
GMCS
D
P--LY
T
KD
QEALKASP
CLSIPQSQWGHTLT
R
QYVID
N
EKL
E
N
F
SV
D
T
Q
L
Q
S
K
F
A
TG
S
V
D
H
T
L
L
---------------
TGV
D
F
M
R
MR
N
DID
S
W
--------------------
F
G
YA
G
SV
A
PSD
-
IY
N
LDR
S
D
-
FDFGAH-PN
P
SG
P
YRVL----
L
KQK
QT
---G
LY
V
Q
D
QA
Q
WDKV
L
V
T
L
GG
-
-
--
-
-
--
RYD
W
A
D
Q
------------
SSFNRDYGN
K
S
-----
ERDD
K
EF
TW
R
G
G
VN
Y
-
L
F
DNG
V
T
P
Y
F
SY
S
E
SF
E
-----
P
---------
A
S
-QT
---
D
A
N
G
DL
-
FAP
S
KG
K
Q
YE
V
G
V
K
YVPE
D
R
PI
VV
T
G
AL
Y
Q
LTKT
N
NLM
--------
A
D
P
N
G
S
L
FS
V
EG
G
EI
R
A
R
GVE
L
E
AK
---
A
A
LS
A
S
VN
V
V
G
S
YT
YTD
AE
YTTD
T
TY
K
GN
TP
AQ
--------
V
P
K
H
MAS
LW
A
D
Y
TFF
D
G
P
LS
G
LT
L
G
T
G
G
RY
T
G
--
S
S
Y---G
D
-
P
A
-
-
N
-S
F
KV
GSY
T
VVDA
LV
RY
D
L
A
R
VGMAG
S
N
V
A
L
H
VNNLFD
RE
YVAS
CFN
T
-
Y
-------
GCFW
GA
E
R
Q
V
VA
TAT
FR
F
fig|749546.3.peg.3726
Escherichia coli MS 185-1
MA
PSKT
A
QPK
HSL
RKIAVV
V
A
T
AVS
G
MSVY
AQA
-
A
V
E
PK-
--
EDT
I
T
V
T
A
A
P
---
-
APQ
E
SA
WGPA
ATIAARQSAT
GTK
TDT
P
IQ
K
V
PQS
I
S
VV
T
A
E
E
M
A
LH
Q
PK
S
V
K
EAL
S
Y
TPGV
A
---
V
G
TR
G
A
S
N
T
Y
D
Y
L
I
I
-
RGF
-
AADG
Q
SQ
N
N
Y
L
N
G
L
KL
-------
Q
G
N
FYND
A
VI
D
PYML
ER
A
E
I
M
RGP
V
S
VL
YG
K
S
S
P
G
G
L
L
NMVSK
R
PT
T
EPL
K
-
E
V
QF
KA
G
T
DSLF
Q
TGF
D
FSDA
L
D
DDG
VY
S
Y
R
L
T
G
LA
RS
A
N
A
QQ
K
GSEE
Q
RY
AI
AP
A--
F
T
WR
PDDK
T
NFT
----------
F
L
SYF
Q
N
E--
-
---
P
E
T
G
YY
G
W-
LP
KE
GT
VEPL
--
P
N
GK
-
-
-----RL
P
T
D
F
N
E
GAK
N
NTY
S
R
NEKM
I
GYS
F
D
H
E
FNDT
F
T
V
R
Q
N
L
R
F
A
Q
N
K
V
S
Q
--
KS
V
YG
-
-
Y
GMCS
D
P--LY
T
KD
QEALKASP
CLSIPQSQWGHTLT
R
QYVID
N
EKL
E
N
F
SV
D
T
Q
L
Q
S
K
F
A
TG
S
V
D
H
T
L
L
---------------
TGV
D
F
M
R
MR
N
DID
S
W
--------------------
F
G
YA
G
SV
A
PSD
-
IY
N
LDR
S
D
-
FDFGAH-PN
P
SG
P
YRVL----
L
KQK
QT
---G
LY
V
Q
D
QA
Q
WDKV
L
V
T
L
GG
-
-
--
-
-
--
RYD
W
A
D
Q
------------
SSFNRDYGN
K
S
-----
ERDD
K
EF
TW
R
G
G
VN
Y
-
L
F
DNG
V
T
P
Y
F
SY
S
E
SF
E
-----
P
---------
A
S
-QT
---
D
A
N
G
DL
-
FAP
S
KG
K
Q
YE
V
G
V
K
YVPE
D
R
PI
VV
T
G
AL
Y
Q
LTKT
N
NLM
--------
A
D
P
N
G
S
L
FS
V
EG
G
EI
R
A
R
GVE
L
E
AK
---
A
A
LS
A
S
VN
V
V
G
S
YT
YTD
AE
YTTD
T
TY
K
GN
TP
AQ
--------
V
P
K
H
MAS
LW
A
D
Y
TFF
D
G
P
LS
G
LT
L
G
T
G
G
RY
T
G
--
S
S
Y---G
D
-
P
A
-
-
N
-S
F
KV
GSY
T
VVDA
LV
RY
D
L
A
R
VGMAG
S
N
V
A
L
H
VNNLFD
RE
YVAS
CFN
T
-
Y
-------
GCFW
GA
E
R
Q
V
VA
TAT
FR
F
fig|749528.3.peg.4662
Escherichia coli MS 45-1
MA
PSKT
A
QPK
HSL
RKIAVV
V
A
T
AVS
G
MSVY
AQA
-
A
V
E
PK-
--
EDT
I
T
V
T
A
A
P
---
-
APQ
E
SA
WGPA
ATIAARQSAT
GTK
TDT
P
IQ
K
V
PQS
I
S
VV
T
A
E
E
M
A
LH
Q
PK
S
V
K
EAL
S
Y
TPGV
A
---
V
G
TR
G
A
S
N
T
Y
D
Y
L
I
I
-
RGF
-
AADG
Q
SQ
N
N
Y
L
N
G
L
KL
-------
Q
G
N
FYND
A
VI
D
PYML
ER
A
E
I
M
RGP
V
S
VL
YG
K
S
S
P
G
G
L
L
NMVSK
R
PT
T
EPL
K
-
E
V
QF
KA
G
T
DSLF
Q
TGF
D
FSDA
L
D
DDG
VY
S
Y
R
L
T
G
LA
RS
A
N
A
QQ
K
GSEE
Q
RY
AI
AP
A--
F
T
WR
PDDK
T
NFT
----------
F
L
SYF
Q
N
E--
-
---
P
E
T
G
YY
G
W-
LP
KE
GT
VEPL
--
P
N
GK
-
-
-----RL
P
T
D
F
N
E
GAK
N
NTY
S
R
NEKM
I
GYS
F
D
H
E
FNDT
F
T
V
R
Q
N
L
R
F
A
Q
N
K
V
S
Q
--
KS
V
YG
-
-
Y
GMCS
D
P--LY
T
KD
QEALKASP
CLSIPQSQWGHTLT
R
QYVID
N
EKL
E
N
F
SV
D
T
Q
L
Q
S
K
F
A
TG
S
V
D
H
T
L
L
---------------
TGV
D
F
M
R
MR
N
DID
S
W
--------------------
F
G
YA
G
SV
A
PSD
-
IY
N
LDR
S
D
-
FDFGAH-PN
P
SG
P
YRVL----
L
KQK
QT
---G
LY
V
Q
D
QA
Q
WDKV
L
V
T
L
GG
-
-
--
-
-
--
RYD
W
A
D
Q
------------
SSFNRDYGN
K
S
-----
ERDD
K
EF
TW
R
G
G
VN
Y
-
L
F
DNG
V
T
P
Y
F
SY
S
E
SF
E
-----
P
---------
A
S
-QT
---
D
A
N
G
DL
-
FAP
S
KG
K
Q
YE
V
G
V
K
YVPE
D
R
PI
VV
T
G
AL
Y
Q
LTKT
N
NLM
--------
A
D
P
N
G
S
L
FS
V
EG
G
EI
R
A
R
GVE
L
E
AK
---
A
A
LS
A
S
VN
V
V
G
S
YT
YTD
AE
YTTD
T
TY
K
GN
TP
AQ
--------
V
P
K
H
MAS
LW
A
D
Y
TFF
D
G
P
LS
G
LT
L
G
T
G
G
RY
T
G
--
S
S
Y---G
D
-
P
A
-
-
N
-S
F
KV
GSY
T
VVDA
LV
RY
D
L
A
R
VGMAG
S
N
V
A
L
H
VNNLFD
RE
YVAS
CFN
T
-
Y
-------
GCFW
GA
E
R
Q
V
VA
TAT
FR
F
fig|753642.3.peg.3470
Escherichia coli NC101
MA
PSKT
A
QPK
HSL
RKIAVV
V
A
T
AVS
G
MSVY
AQA
-
A
V
E
PK-
--
EDT
I
T
V
T
A
A
P
---
-
APQ
E
SA
WGPA
ATIAARQSAT
GTK
TDT
P
IQ
K
V
PQS
I
S
VV
T
A
E
E
M
A
LH
Q
PK
S
V
K
EAL
S
Y
TPGV
A
---
V
G
TR
G
A
S
N
T
Y
D
Y
L
I
I
-
RGF
-
AADG
Q
SQ
N
N
Y
L
N
G
L
KL
-------
Q
G
N
FYND
A
VI
D
PYML
ER
A
E
I
M
RGP
V
S
VL
YG
K
S
S
P
G
G
L
L
NMVSK
R
PT
T
EPL
K
-
E
V
QF
KA
G
T
DSLF
Q
TGF
D
FSDA
L
D
DDG
VY
S
Y
R
L
T
G
LA
RS
A
N
A
QQ
K
GSEE
Q
RY
AI
AP
A--
F
T
WR
PDDK
T
NFT
----------
F
L
SYF
Q
N
E--
-
---
P
E
T
G
YY
G
W-
LP
KE
GT
VEPL
--
P
N
GK
-
-
-----RL
P
T
D
F
N
E
GAK
N
NTY
S
R
NEKM
I
GYS
F
D
H
E
FNDT
F
T
V
R
Q
N
L
R
F
A
Q
N
K
V
S
Q
--
KS
V
YG
-
-
Y
GMCS
D
P--LY
T
KD
QEALKASP
CLSIPQSQWGHTLT
R
QYVID
N
EKL
E
N
F
SV
D
T
Q
L
Q
S
K
F
A
TG
S
V
D
H
T
L
L
---------------
TGV
D
F
M
R
MR
N
DID
S
W
--------------------
F
G
YA
G
SV
A
PSD
-
IY
N
LDR
S
D
-
FDFGAH-PN
P
SG
P
YRVL----
L
KQK
QT
---G
LY
V
Q
D
QA
Q
WDKV
L
V
T
L
GG
-
-
--
-
-
--
RYD
W
A
D
Q
------------
SSFNRDYGN
K
S
-----
ERDD
K
EF
TW
R
G
G
VN
Y
-
L
F
DNG
V
T
P
Y
F
SY
S
E
SF
E
-----
P
---------
A
S
-QT
---
D
A
N
G
DL
-
FAP
S
KG
K
Q
YE
V
G
V
K
YVPE
D
R
PI
VV
T
G
AL
Y
Q
LTKT
N
NLM
--------
A
D
P
N
G
S
L
FS
V
EG
G
EI
R
A
R
GVE
L
E
AK
---
A
A
LS
A
S
VN
V
V
G
S
YT
YTD
AE
YTTD
T
TY
K
GN
TP
AQ
--------
V
P
K
H
MAS
LW
A
D
Y
TFF
D
G
P
LS
G
LT
L
G
T
G
G
RY
T
G
--
S
S
Y---G
D
-
P
A
-
-
N
-S
F
KV
GSY
T
VVDA
LV
RY
D
L
A
R
VGMAG
S
N
V
A
L
H
VNNLFD
RE
YVAS
CFN
T
-
Y
-------
GCFW
GA
E
R
Q
V
VA
TAT
FR
F
fig|656440.3.peg.5242
Escherichia coli TA206
MA
PSKT
A
QPK
HSL
RKIAVV
V
A
T
AVS
G
MSVY
AQA
-
A
V
E
PK-
--
EDT
I
T
V
T
A
A
P
---
-
APQ
E
SA
WGPA
ATIAARQSAT
GTK
TDT
P
IQ
K
V
PQS
I
S
VV
T
A
E
E
M
A
LH
Q
PK
S
V
K
EAL
S
Y
TPGV
A
---
V
G
TR
G
A
S
N
T
Y
D
Y
L
I
I
-
RGF
-
AADG
Q
SQ
N
N
Y
L
N
G
L
KM
-------
Q
G
N
FYND
A
VI
D
PYML
ER
A
E
I
M
RGP
V
S
VL
YG
K
S
S
P
G
G
L
L
NMVSK
R
PT
T
EPL
K
-
E
V
QF
KA
G
T
DSLF
Q
TGF
D
FSDA
L
D
DDG
VY
S
Y
R
L
T
G
LA
RS
A
N
A
QQ
K
GSEE
Q
RY
AI
AP
A--
F
T
WR
PDDK
T
NFT
----------
F
L
SYF
Q
N
E--
-
---
P
E
T
G
YY
G
W-
LP
KE
GT
VEPL
--
P
N
GK
-
-
-----RL
P
T
D
F
N
E
GAK
N
NTY
S
R
NEKM
I
GYS
F
D
H
E
FNDT
F
T
V
R
Q
N
L
R
F
A
Q
N
K
V
S
Q
--
KS
V
YG
-
-
Y
GMCS
D
P--LY
T
KD
QEALKASP
CLSIPQSQWGHTLT
R
QYVID
N
EKL
E
N
F
SV
D
T
Q
L
Q
S
K
F
A
TG
S
V
G
H
T
L
L
---------------
TGV
D
F
M
R
MR
N
DID
S
W
--------------------
F
G
YA
G
SV
A
PSD
-
IY
N
LDR
S
D
-
FDFGAH-PN
P
SG
P
YRVL----
L
KQK
QT
---G
LY
V
Q
D
QA
Q
WDKV
L
V
T
L
GG
-
-
--
-
-
--
RYD
W
A
D
Q
------------
SSFNRDYGN
K
S
-----
ERDD
K
EF
TW
R
G
G
VN
Y
-
L
F
DNG
V
T
P
Y
F
SY
S
E
SF
E
-----
P
---------
A
S
-QT
---
D
A
N
G
DL
-
FAP
S
KG
K
Q
YE
V
G
V
K
YVPE
D
R
PI
VV
T
G
AL
Y
Q
LTKT
N
NLM
--------
A
D
P
N
G
S
L
FS
V
EG
G
EI
R
A
R
GVE
L
E
AK
---
A
A
LS
A
S
VN
V
V
G
S
YT
YTD
AE
YTTD
T
TY
K
GN
TP
AQ
--------
V
P
K
H
MAS
LW
A
D
Y
TFF
D
G
P
LS
G
LT
L
G
T
G
G
RY
T
G
--
S
S
Y---G
D
-
P
A
-
-
N
-S
F
KV
GSY
T
VVDA
LV
RY
D
L
A
R
VGMAG
S
N
V
A
L
H
VNNLFD
RE
YVAS
CFN
T
-
Y
-------
GCFW
GA
E
R
Q
V
VA
TAT
FR
F
fig|656379.3.peg.393
Escherichia coli FVEC1302
MAR
SKT
A
QPK
HSL
RKIAVV
V
A
T
AVS
G
MSVY
AQA
-
A
V
E
PK-
--
EDT
I
T
V
T
A
A
P
---
-
APQ
E
SA
WGPA
ATIAARQSAT
GTK
TDT
P
IQ
K
V
PQS
I
S
VV
T
A
E
E
M
A
LH
Q
PK
S
V
K
EAL
S
Y
TPGV
A
---
V
G
TR
G
A
S
N
T
Y
D
Y
L
I
I
-
RGF
-
AADG
Q
SQ
N
N
Y
L
N
G
L
KM
-------
Q
G
N
FYND
A
VI
D
PYML
ER
A
E
I
M
RGP
V
S
VL
YG
K
S
S
P
G
G
L
L
NMVSK
R
PT
T
EPL
K
-
E
I
QF
KA
G
T
DSLF
Q
TGF
D
FSDA
L
D
DDG
VY
S
Y
R
L
T
G
IA
RS
A
N
A
QQ
K
GAEE
Q
RY
AI
AP
A--
F
T
WR
PDDK
T
NFT
----------
F
L
SYF
Q
N
E--
-
---
P
E
T
G
YY
G
W-
LP
KE
GT
VEPL
--
P
N
GK
-
-
-----RL
P
T
D
F
N
E
GAK
N
NTY
S
R
NEKMVGYS
F
D
H
E
FNDT
F
T
V
R
Q
N
L
R
F
A
Q
N
K
V
S
Q
--
KS
V
YG
-
-
Y
GMCS
D
P--LY
T
KD
DDALKASP
CLSIPQSEWNHTLT
R
QYVID
N
EKL
E
N
F
SV
D
T
Q
L
Q
S
K
F
A
TG
S
V
E
H
T
L
L
---------------
TGV
D
F
M
R
MR
N
DID
S
W
--------------------
F
G
YA
G
SV
A
PSD
-
IY
N
LDR
S
D
-
FDFGAH-PD
P
SG
P
YRVL----
L
KQK
QT
---G
LY
V
Q
D
QA
Q
WDKV
L
V
T
L
GG
-
-
--
-
-
--
RYD
W
A
E
Q
------------
SSFNRDYGN
K
S
-----
DRDD
K
QF
TW
R
G
G
VN
Y
-
L
F
DNG
V
T
P
Y
F
SY
S
E
SF
E
-----
P
---------
A
S
-LT
---
D
A
N
G
DL
-
FAP
S
KG
K
Q
YE
V
G
V
K
YVPE
D
R
PI
VL
T
G
AL
Y
Q
LTKT
N
NLM
--------
A
D
P
NNPN
FS
I
EG
G
EI
R
A
R
GVE
L
E
AK
---
A
A
LS
A
S
VN
V
V
G
S
YT
YTD
AE
YTTD
T
TY
K
GN
TP
AQ
--------
V
P
K
H
MAS
LW
A
D
Y
TFF
D
G
P
LS
G
LT
L
G
T
G
G
RY
T
G
--
S
S
Y---G
D
-
P
A
-
-
N
-S
F
KV
GSY
T
VVDA
LV
RY
D
L
A
R
VGMAG
S
N
V
A
L
H
VNNLFD
RE
YVAS
CFN
T
-
Y
-------
GCFW
GA
E
R
Q
V
VA
TAT
FR
F
fig|656380.3.peg.330
Escherichia coli FVEC1412
MAR
SKT
A
QPK
HSL
RKIAVV
V
A
T
AVS
G
MSVY
AQA
-
A
V
E
PK-
--
EDT
I
T
V
T
A
A
P
---
-
APQ
E
SA
WGPA
ATIAARQSAT
GTK
TDT
P
IQ
K
V
PQS
I
S
VV
T
A
E
E
M
A
LH
Q
PK
S
V
K
EAL
S
Y
TPGV
A
---
V
G
TR
G
A
S
N
T
Y
D
Y
L
I
I
-
RGF
-
AADG
Q
SQ
N
N
Y
L
N
G
L
KM
-------
Q
G
N
FYND
A
VI
D
PYML
ER
A
E
I
M
RGP
V
S
VL
YG
K
S
S
P
G
G
L
L
NMVSK
R
PT
T
EPL
K
-
E
I
QF
KA
G
T
DSLF
Q
TGF
D
FSDA
L
D
DDG
VY
S
Y
R
L
T
G
IA
RS
A
N
A
QQ
K
GAEE
Q
RY
AI
AP
A--
F
T
WR
PDDK
T
NFT
----------
F
L
SYF
Q
N
E--
-
---
P
E
T
G
YY
G
W-
LP
KE
GT
VEPL
--
P
N
GK
-
-
-----RL
P
T
D
F
N
E
GAK
N
NTY
S
R
NEKMVGYS
F
D
H
E
FNDT
F
T
V
R
Q
N
L
R
F
A
Q
N
K
V
S
Q
--
KS
V
YG
-
-
Y
GMCS
D
P--LY
T
KD
DDALKASP
CLSIPQSEWNHTLT
R
QYVID
N
EKL
E
N
F
SV
D
T
Q
L
Q
S
K
F
A
TG
S
V
E
H
T
L
L
---------------
TGV
D
F
M
R
MR
N
DID
S
W
--------------------
F
G
YA
G
SV
A
PSD
-
IY
N
LDR
S
D
-
FDFGAH-PD
P
SG
P
YRVL----
L
KQK
QT
---G
LY
V
Q
D
QA
Q
WDKV
L
V
T
L
GG
-
-
--
-
-
--
RYD
W
A
E
Q
------------
SSFNRDYGN
K
S
-----
DRDD
K
QF
TW
R
G
G
VN
Y
-
L
F
DNG
V
T
P
Y
F
SY
S
E
SF
E
-----
P
---------
A
S
-LT
---
D
A
N
G
DL
-
FAP
S
KG
K
Q
YE
V
G
V
K
YVPE
D
R
PI
VL
T
G
AL
Y
Q
LTKT
N
NLM
--------
A
D
P
NNPN
FS
I
EG
G
EI
R
A
R
GVE
L
E
AK
---
A
A
LS
A
S
VN
V
V
G
S
YT
YTD
AE
YTTD
T
TY
K
GN
TP
AQ
--------
V
P
K
H
MAS
LW
A
D
Y
TFF
D
G
P
LS
G
LT
L
G
T
G
G
RY
T
G
--
S
S
Y---G
D
-
P
A
-
-
N
-S
F
KV
GSY
T
VVDA
LV
RY
D
L
A
R
VGMAG
S
N
V
A
L
H
VNNLFD
RE
YVAS
CFN
T
-
Y
-------
GCFW
GA
E
R
Q
V
VA
TAT
FR
F
fig|749549.3.peg.4666
Escherichia coli MS 198-1
MAR
SKT
A
QPK
HSL
RKIAVV
V
A
T
AVS
G
MSVY
AQA
-
A
V
E
PK-
--
EDT
I
T
V
T
A
A
P
---
-
APQ
E
SA
WGPA
ATIAARQSAT
GTK
TDT
P
IQ
K
V
PQS
I
S
VV
T
A
E
E
M
A
LH
Q
PK
S
V
K
EAL
S
Y
TPGV
A
---
V
G
TR
G
A
S
N
T
Y
D
Y
L
I
I
-
RGF
-
AADG
Q
SQ
N
N
Y
L
N
G
L
KM
-------
Q
G
N
FYND
A
VI
D
PYML
ER
A
E
I
M
RGP
V
S
VL
YG
K
S
S
P
G
G
L
L
NMVSK
R
PT
T
EPL
K
-
E
I
QF
KA
G
T
DSLF
Q
TGF
D
FSDA
L
D
DDG
VY
S
Y
R
L
T
G
IA
RS
A
N
A
QQ
K
GAEE
Q
RY
AI
AP
A--
F
T
WR
PDDK
T
NFT
----------
F
L
SYF
Q
N
E--
-
---
P
E
T
G
YY
G
W-
LP
KE
GT
VEPL
--
P
N
GK
-
-
-----RL
P
T
D
F
N
E
GAK
N
NTY
S
R
NEKMVGYS
F
D
H
E
FNDT
F
T
V
R
Q
N
L
R
F
A
Q
N
K
V
S
Q
--
KS
V
YG
-
-
Y
GMCS
D
P--LY
T
KD
DDALKASP
CLSIPQSEWNHTLT
R
QYVID
N
EKL
E
N
F
SV
D
T
Q
L
Q
S
K
F
A
TG
S
V
E
H
T
L
L
---------------
TGV
D
F
M
R
MR
N
DID
S
W
--------------------
F
G
YA
G
SV
A
PSD
-
IY
N
LDR
S
D
-
FDFGAH-PD
P
SG
P
YRVL----
L
KQK
QT
---G
LY
V
Q
D
QA
Q
WDKV
L
V
T
L
GG
-
-
--
-
-
--
RYD
W
A
E
Q
------------
SSFNRDYGN
K
S
-----
DRDD
K
QF
TW
R
G
G
VN
Y
-
L
F
DNG
V
T
P
Y
F
SY
S
E
SF
E
-----
P
---------
A
S
-LT
---
D
A
N
G
DL
-
FAP
S
KG
K
Q
YE
V
G
V
K
YVPE
D
R
PI
VL
T
G
AL
Y
Q
LTKT
N
NLM
--------
A
D
P
NNPN
FS
I
EG
G
EI
R
A
R
GVE
L
E
AK
---
A
A
LS
A
S
VN
V
V
G
S
YT
YTD
AE
YTTD
T
TY
K
GN
TP
AQ
--------
V
P
K
H
MAS
LW
A
D
Y
TFF
D
G
P
LS
G
LT
L
G
T
G
G
RY
T
G
--
S
S
Y---G
D
-
P
A
-
-
N
-S
F
KV
GSY
T
VVDA
LV
RY
D
L
A
R
VGMAG
S
N
V
A
L
H
VNNLFD
RE
YVAS
CFN
T
-
Y
-------
GCFW
GA
E
R
Q
V
VA
TAT
FR
F
fig|749527.3.peg.3258
Escherichia coli MS 21-1
MAR
SKT
A
QPK
HSL
RKIAVV
V
A
T
AVS
G
MSVY
AQA
-
A
V
E
PK-
--
EDT
I
T
V
T
A
A
P
---
-
APQ
E
SA
WGPA
ATIAARQSAT
GTK
TDT
P
IQ
K
V
PQS
I
S
VV
T
A
E
E
M
A
LH
Q
PK
S
V
K
EAL
S
Y
TPGV
A
---
V
G
TR
G
A
S
N
T
Y
D
Y
L
I
I
-
RGF
-
AADG
Q
SQ
N
N
Y
L
N
G
L
KM
-------
Q
G
N
FYND
A
VI
D
PYML
ER
A
E
I
M
RGP
V
S
VL
YG
K
S
S
P
G
G
L
L
NMVSK
R
PT
T
EPL
K
-
E
I
QF
KA
G
T
DSLF
Q
TGF
D
FSDA
L
D
DDG
VY
S
Y
R
L
T
G
IA
RS
A
N
A
QQ
K
GAEE
Q
RY
AI
AP
A--
F
T
WR
PDDK
T
NFT
----------
F
L
SYF
Q
N
E--
-
---
P
E
T
G
YY
G
W-
LP
KE
GT
VEPL
--
P
N
GK
-
-
-----RL
P
T
D
F
N
E
GAK
N
NTY
S
R
NEKMVGYS
F
D
H
E
FNDT
F
T
V
R
Q
N
L
R
F
A
Q
N
K
V
S
Q
--
KS
V
YG
-
-
Y
GMCS
D
P--LY
T
KD
DDALKASP
CLSIPQSEWNHTLT
R
QYVID
N
EKL
E
N
F
SV
D
T
Q
L
Q
S
K
F
A
TG
S
V
E
H
T
L
L
---------------
TGV
D
F
M
R
MR
N
DID
S
W
--------------------
F
G
YA
G
SV
A
PSD
-
IY
N
LDR
S
D
-
FDFGAH-PD
P
SG
P
YRVL----
L
KQK
QT
---G
LY
V
Q
D
QA
Q
WDKV
L
V
T
L
GG
-
-
--
-
-
--
RYD
W
A
E
Q
------------
SSFNRDYGN
K
S
-----
DRDD
K
QF
TW
R
G
G
VN
Y
-
L
F
DNG
V
T
P
Y
F
SY
S
E
SF
E
-----
P
---------
A
S
-LT
---
D
A
N
G
DL
-
FAP
S
KG
K
Q
YE
V
G
V
K
YVPE
D
R
PI
VL
T
G
AL
Y
Q
LTKT
N
NLM
--------
A
D
P
NNPN
FS
I
EG
G
EI
R
A
R
GVE
L
E
AK
---
A
A
LS
A
S
VN
V
V
G
S
YT
YTD
AE
YTTD
T
TY
K
GN
TP
AQ
--------
V
P
K
H
MAS
LW
A
D
Y
TFF
D
G
P
LS
G
LT
L
G
T
G
G
RY
T
G
--
S
S
Y---G
D
-
P
A
-
-
N
-S
F
KV
GSY
T
VVDA
LV
RY
D
L
A
R
VGMAG
S
N
V
A
L
H
VNNLFD
RE
YVAS
CFN
T
-
Y
-------
GCFW
GA
E
R
Q
V
VA
TAT
FR
F
fig|331112.3.peg.150
Escherichia coli HS
MAR
SKT
A
QPK
HSL
RKIAVV
V
A
T
AVS
G
MSVY
AQA
-
A
V
E
PK-
--
EDT
I
T
V
T
A
A
P
---
-
APQ
E
SA
WGPA
ATIAAKHSAT
A
TK
TDT
P
IE
K
T
PQS
I
S
VV
T
N
E
E
M
Q
M
H
Q
FQ
S
V
K
EAL
G
Y
TPGV
T
---
V
S
SR
G
A
S
N
T
Y
D
F
V
I
I
-
RGF
-
SSVG
L
NQ
N
N
Y
L
DG
L
KL
-------
Q
G
N
FYND
A
VI
D
PYML
ERVE
LM
RGP
T
S
VL
YG
K
S
N
P
G
G
I
I
S
MVSK
R
PT
T
EPL
K
-
E
I
QF
KM
G
T
DNLF
Q
TGF
D
FSDA
L
D
D
N
G
EF
S
Y
R
L
T
G
LA
RS
T
N
E
QQ
K
NSES
Q
RY
TI
AP
S--
F
S
WR
PDDK
T
NFT
----------
F
L
SYF
Q
N
E--
-
---
P
E
T
G
YY
G
W-
LP
KE
GT
VEPL
--
P
N
GK
-
-
-----RL
P
T
D
F
N
E
GAS
N
NTY
S
R
N
Q
KMVGYS
FEH
G
FNDT
F
T
V
R
Q
N
L
R
F
SE
M
K
T
S
Q
--
KS
V
YG
-
-
T
GIAN
D
-----
-
--
--------
---------GHTLN
R
GTVVD
N
ERL
Q
N
F
SV
D
T
Q
L
E
S
K
F
A
TG
E
V
E
H
T
L
L
---------------
TGV
D
F
M
R
MR
N
DIN
A
S
--------------------
F
G
--
-
S
A
P
SID
-
LY
N
KYH
P
E
Y
FAFG-----
N
AE
P
YQ-M----
N
ESK
QT
---G
I
Y
V
Q
D
QA
E
WNKW
V
F
T
L
GG
-
-
--
-
-
--
RYD
W
S
K
Q
------------
ATTVRENSY
T
P
TEGYI
ERND
H
QF
TW
R
G
G
VN
Y
-
L
F
DNG
I
S
P
Y
F
SY
S
Q
SF
E
-----
P
---------
S
A
FDL
---
W
S
N
P
RV
S
Y
K
P
S
KG
E
Q
YE
A
G
V
K
YVPN
D
M
P
V
VV
T
G
A
V
Y
Q
LTKT
N
NLT
--------
A
D
P
TNPL
AQ
V
PA
G
EI
R
A
R
GVE
L
E
AK
---
A
A
L
N
A
NI
NL
T
A
S
YT
YTD
AE
YTKD
T
NL
K
G
K
TP
E
Q
--------
V
PEH
MAS
LW
G
D
Y
TFN
E
G
P
LS
G
LT
L
G
T
G
G
R
F
I
G
--
S
S
Y---G
D
-
P
A
-
-
N
-T
F
KV
GS
A
A
V
M
DA
VV
K
Y
D
L
A
R
F
GMAG
S
S
L
A
V
NVNNL
L
D
RE
YVAS
CFQ
T
-
Y
-------
GCFW
GA
E
R
Q
V
VA
TAT
FR
F
fig|749533.3.peg.3179
Escherichia coli MS 84-1
MAR
SKT
A
QPK
HSL
RKIAVV
V
A
T
AVS
G
MSVY
AQA
-
A
V
E
PK-
--
EDT
I
T
V
T
A
A
P
---
-
APQ
E
SA
WGPA
ATIAAKHSAT
A
TK
TDT
P
IE
K
T
PQS
I
S
VV
T
N
E
E
M
Q
M
H
Q
FQ
S
V
K
EAL
G
Y
TPGV
T
---
V
S
SR
G
A
S
N
T
Y
D
F
V
I
I
-
RGF
-
SSVG
L
NQ
N
N
Y
L
DG
L
KL
-------
Q
G
N
FYND
A
VI
D
PYML
ERVE
LM
RGP
T
S
VL
YG
K
S
N
P
G
G
I
I
S
MVSK
R
PT
T
EPL
K
-
E
I
QF
KM
G
T
DNLF
Q
TGF
D
FSDA
L
D
D
N
G
EF
S
Y
R
L
T
G
LA
RS
T
N
E
QQ
K
NSES
Q
RY
TI
AP
S--
F
S
WR
PDDK
T
NFT
----------
F
L
SYF
Q
N
E--
-
---
P
E
T
G
YY
G
W-
LP
KE
GT
VEPL
--
P
N
GK
-
-
-----RL
P
T
D
F
N
E
GAS
N
NTY
S
R
N
Q
KMVGYS
FEH
G
FNDT
F
T
V
R
Q
N
L
R
F
SE
M
K
T
S
Q
--
KS
V
YG
-
-
T
GIAN
D
-----
-
--
--------
---------GHTLN
R
GTVVD
N
ERL
Q
N
F
SV
D
T
Q
L
E
S
K
F
A
TG
E
V
E
H
T
L
L
---------------
TGV
D
F
M
R
MR
N
DIN
A
S
--------------------
F
G
--
-
S
A
P
SID
-
LY
N
KYH
P
E
Y
FAFG-----
N
AE
P
YQ-M----
N
ESK
QT
---G
I
Y
V
Q
D
QA
E
WNKW
V
F
T
L
GG
-
-
--
-
-
--
RYD
W
S
K
Q
------------
ATTVRENSY
T
P
TEGYI
ERND
H
QF
TW
R
G
G
VN
Y
-
L
F
DNG
I
S
P
Y
F
SY
S
Q
SF
E
-----
P
---------
S
A
FDL
---
W
S
N
P
RV
S
Y
K
P
S
KG
E
Q
YE
A
G
V
K
YVPN
D
M
P
V
VV
T
G
A
V
Y
Q
LTKT
N
NLT
--------
A
D
P
TNPL
AQ
V
PA
G
EI
R
A
R
GVE
L
E
AK
---
A
A
L
N
A
NI
NL
T
A
S
YT
YTD
AE
YTKD
T
NL
K
G
K
TP
E
Q
--------
V
PEH
MAS
LW
G
D
Y
TFN
E
G
P
LS
G
LT
L
G
T
G
G
R
F
I
G
--
S
S
Y---G
D
-
P
A
-
-
N
-T
F
KV
GS
A
A
V
M
DA
VV
K
Y
D
L
A
R
F
GMAG
S
S
L
A
V
NVNNL
L
D
RE
YVAS
CFQ
T
-
Y
-------
GCFW
GA
E
R
Q
V
VA
TAT
FR
F
fig|656393.3.peg.769
Escherichia coli H299
MAR
SKT
A
QPK
HSL
RKIAVV
V
A
T
AVS
G
MSVY
AQA
-
A
V
E
PK-
--
EDT
I
T
V
T
A
A
P
---
-
APQ
E
SA
WGPA
ATIAAKHSAT
A
TK
TDT
P
IE
K
T
PQS
I
S
VV
T
N
E
E
I
Q
M
H
Q
FQ
S
V
K
EAL
G
Y
TPGV
T
---
V
S
SR
G
A
S
N
T
Y
D
F
V
I
I
-
RGF
-
SSVG
L
NQ
N
N
Y
L
DG
L
KL
-------
Q
G
N
FYND
A
VI
D
PYML
ERVE
LM
RGP
T
S
VL
YG
K
S
N
P
G
G
I
I
S
MVSK
R
PT
T
EPL
K
-
E
I
QF
KM
G
T
DNLF
Q
TGF
D
FSDA
L
D
D
N
G
EF
S
Y
R
L
T
G
LA
RS
T
N
E
QQ
K
NSES
Q
RY
TI
AP
S--
F
S
WR
PDDK
T
NFT
----------
F
L
SYF
Q
N
E--
-
---
P
E
T
G
YY
G
W-
LP
KE
GT
VEPL
--
P
N
GK
-
-
-----RL
P
T
D
F
N
E
GAS
N
NTY
S
R
N
Q
KMVGYS
FEH
G
FNDT
F
T
V
R
Q
N
L
R
F
SE
M
K
T
S
Q
--
KS
V
YG
-
-
T
GIAS
D
-----
-
--
--------
---------GHTLN
R
GTVVD
N
ERL
Q
N
F
SV
D
T
Q
L
E
S
K
F
A
TG
E
V
E
H
T
L
L
---------------
TGV
D
F
M
R
MR
N
DIN
A
S
--------------------
F
G
--
-
S
A
P
SID
-
LY
N
KYH
P
E
Y
FAFG-----
N
AE
P
YQ-M----
N
ESK
QT
---G
I
Y
V
Q
D
QA
E
WNKW
V
F
T
L
GG
-
-
--
-
-
--
RYD
W
S
K
Q
------------
ATTVRENSY
T
P
TEGYI
ERND
H
QF
TW
R
G
G
VN
Y
-
L
F
DNG
I
S
P
Y
F
SY
S
Q
SF
E
-----
P
---------
S
A
FDL
---
W
S
N
P
RV
S
Y
K
P
S
KG
E
Q
YE
A
G
V
K
YVPN
D
M
P
V
VV
T
G
A
V
Y
Q
LTKT
N
NLT
--------
A
D
P
TNPL
AQ
V
PA
G
EI
R
A
R
GVE
L
E
AK
---
A
A
L
N
A
NI
NL
T
A
S
YT
YTD
AE
YTKD
T
NL
K
G
K
TP
E
Q
--------
V
PEH
MAS
LW
G
D
Y
TFN
E
G
P
LS
G
LT
L
G
T
G
G
R
F
I
G
--
S
S
Y---G
D
-
P
A
-
-
N
-T
F
KV
GS
A
A
V
M
DA
VV
K
Y
D
L
A
R
F
GMAG
S
S
L
A
V
NVNNL
L
D
RE
YVAS
CFQ
T
-
Y
-------
GCFW
GA
E
R
Q
V
VA
TAT
FR
F
fig|574521.7.peg.165
Escherichia coli O127:H6 str. E2348/69
MAR
SKT
A
QPK
HSL
RKIAVV
V
A
T
AVS
G
MSVY
AQA
-
A
V
E
PK-
--
EDT
I
T
V
T
A
A
P
---
-
APQ
E
SA
WGPA
ATIAAKHSAT
A
TK
TDT
P
IE
K
T
PQS
I
S
VV
T
R
E
E
M
D
I
K
Q
PA
T
V
K
EAL
D
Y
TP
S
V
-
---
F
S
TR
G
S
S
T
T
Y
D
V
V
S
I
-
RGF
T
TAST
V
NT
N
Q
Y
L
DG
L
KL
-------
Q
G
DN
Y
SE
A
SI
D
PYFL
ERVE
LL
RGP
V
S
VL
YG
K
S
H
P
G
G
V
VS
MVSK
R
P
S
T
DPI
K
-
E
I
QF
KM
G
T
DNLW
Q
TGF
D
FSDA
I
D
DDG
VW
S
Y
R
L
T
G
LG
RS
Q
DA
QQ
K
YAKT
T
RY
AV
AP
S--
F
S
WR
PDDK
T
DFT
----------
F
L
SNF
Q
S
D--
-
---
P
D
A
G
YY
G
W-
LP
RQ
GT
VVPY
QD
A
N
G
S
-
-
---WHKL
P
T
D
F
N
E
GEK
D
NKM
S
R
RQQLI
GYS
F
A
H
E
FNDT
F
T
V
R
Q
N
L
R
YT
R
I
H
T
L
Y
--
DA
V
YG
-
-
N
GYIA
P
A----
-
--
--------
-----------QIS
R
AYVRS
D
EDL
N
S
F
TV
D
T
Q
L
Q
S
N
F
A
I
G
A
V
A
H
T
L
L
---------------
TGV
D
Y
L
R
MR
N
DID
A
N
--------------------
Y
G
TA
NPIS
MTD
P
QY
G
NAN
I
N
-
INF------
-
--
P
YAVI----
N
RQE
QT
---G
LY
I
Q
D
QS
E
WNKW
V
L
T
L
GG
-
-
--
-
-
--
RYD
F
A
K
T
------------
STYTRSTSS
L
D
-----
EIND
Q
QF
TW
R
G
G
IN
Y
-
L
F
DNG
I
S
P
Y
F
SY
S
E
SF
E
-----
P
---------
V
S
-GA
---
T
K
E
G
KP
-
F
D
P
S
R
G
K
Q
YE
A
G
V
K
YVPK
D
T
P
V
TV
T
A
SV
F
Q
LTKD
K
NLT
--------
A
D
P
SN
T
L
FS
V
Q
G
G
EI
R
S
R
G
F
EIE
AK
---
A
A
V
N
A
NI
N
V
T
AA
Y
S
YTD
AE
YTKD
T
LY
K
G
K
RP
A
E
--------
V
P
R
N
MAS
LW
A
D
Y
TFH
E
T
A
LS
G
L
SL
G
A
G
A
RY
F
G
DT
S
S
FYTTG
D
-
K
T
-
-
N
QT
F
NV
G
G
Y
T
L
VDA
MI
K
Y
D
L
A
R
F
GM
P
G
S
S
V
G
V
NVNNLFD
RE
YV
S
S
CYR
D
-
Y
-------
ACYW
GA
E
R
Q
V
VA
TAT
FR
F
fig|670897.3.peg.1978
Escherichia coli 2362-75
MAR
SKT
A
QPK
HSL
RKIAVV
V
A
T
AVS
G
MSVY
AQA
-
A
V
E
PK-
--
EDT
I
T
V
T
A
A
P
---
-
APQ
E
SA
WGPA
ATIAAKHSAT
A
TK
TDT
P
IE
K
T
PQS
I
S
VV
T
R
E
E
M
D
I
K
Q
PA
T
V
K
EAL
D
Y
TP
S
V
-
---
F
S
TR
G
S
S
T
T
Y
D
V
V
S
I
-
RGF
T
TAST
V
NT
N
Q
Y
L
DG
L
KL
-------
Q
G
DN
Y
SE
A
SI
D
PYFL
ERVE
LL
RGP
V
S
VL
YG
K
S
H
P
G
G
V
VS
MVSK
R
P
S
T
DPI
K
-
E
I
QF
KM
G
T
DNLW
Q
TGF
D
FSDA
I
D
DDG
VW
S
Y
R
L
T
G
LG
RS
Q
DA
QQ
K
YAKT
T
RY
AV
AP
S--
F
S
WR
PDDK
T
DFT
----------
F
L
SNF
Q
S
D--
-
---
P
D
A
G
YY
G
W-
LP
RQ
GT
VVPY
QD
A
N
G
S
-
-
---WHKL
P
T
D
F
N
E
GEK
D
NKM
S
R
RQQLI
GYS
F
A
H
E
FNDT
F
T
V
R
Q
N
L
R
YT
R
I
H
T
L
Y
--
DA
V
YG
-
-
N
GYIA
P
A----
-
--
--------
-----------QIS
R
AYVRS
D
EDL
N
S
F
TV
D
T
Q
L
Q
S
N
F
A
I
G
A
V
A
H
T
L
L
---------------
TGV
D
Y
L
R
MR
N
DID
A
N
--------------------
Y
G
TA
NPIS
MTD
P
QY
G
NAN
I
N
-
INF------
-
--
P
YAVI----
N
RQE
QT
---G
LY
I
Q
D
QS
E
WNKW
V
L
T
L
GG
-
-
--
-
-
--
RYD
F
A
K
T
------------
STYTRSTSS
L
D
-----
EIND
Q
QF
TW
R
G
G
IN
Y
-
L
F
DNG
I
S
P
Y
F
SY
S
E
SF
E
-----
P
---------
V
S
-GA
---
T
K
E
G
KP
-
F
D
P
S
R
G
K
Q
YE
A
G
V
K
YVPK
D
T
P
V
TV
T
A
SV
F
Q
LTKD
K
NLT
--------
A
D
P
SN
T
L
FS
V
Q
G
G
EI
R
S
R
G
F
EIE
AK
---
A
A
V
N
A
NI
N
V
T
AA
Y
S
YTD
AE
YTKD
T
LY
K
G
K
RP
A
E
--------
V
P
R
N
MAS
LW
A
D
Y
TFH
E
T
A
LS
G
L
SL
G
A
G
A
RY
F
G
DT
S
S
FYTTG
D
-
K
T
-
-
N
QT
F
NV
G
G
Y
T
L
VDA
MI
K
Y
D
I
A
R
F
GM
P
G
S
S
V
G
V
NVNNLFD
RE
YV
S
S
CYR
D
-
Y
-------
ACYW
GA
E
R
Q
V
VA
TAT
FR
F
fig|656419.3.peg.319
Escherichia coli M718
MAR
SKT
A
QPK
HSL
RKIAVV
V
A
T
AVS
G
MSVY
AQA
-
A
V
E
PK-
--
EDT
I
T
V
T
A
A
P
---
-
APQ
E
SA
WGPA
ATIAAKHSAT
A
TK
TDT
P
IE
K
T
PQS
I
S
VV
T
R
E
E
M
D
I
K
Q
PA
T
V
K
EAL
D
Y
TP
S
V
-
---
F
S
TR
G
S
S
T
T
Y
D
V
V
S
I
-
RGF
T
TPST
V
NT
N
Q
Y
L
DG
L
KL
-------
Q
G
DN
Y
SE
A
SI
D
PYFL
ERVE
LL
RGP
V
S
VL
YG
K
S
H
P
G
G
V
VS
MVSK
R
P
S
T
DPI
K
-
E
I
QF
KM
G
T
DNLW
Q
TGF
D
FSDA
I
D
DDG
VW
S
Y
R
L
T
G
LG
RS
Q
DA
QQ
K
YAKT
T
RY
AV
AP
S--
F
S
WR
PDDK
T
DLT
----------
F
L
SNF
Q
S
D--
-
---
P
D
A
G
YY
G
W-
LP
RQ
GT
VVPY
QD
A
N
G
S
-
-
---WHKL
P
T
D
F
N
E
GEK
D
NKM
S
R
RQQLI
GYS
F
A
H
E
FNDT
F
T
V
R
Q
N
L
R
YT
R
I
H
T
L
Y
--
DA
V
YG
-
-
N
SYIA
P
A----
-
--
--------
-----------QIS
R
AYVRS
D
EDL
N
S
F
TV
D
T
Q
L
Q
S
N
F
A
TG
A
V
A
H
T
L
L
---------------
TGV
D
Y
L
R
MR
N
DID
A
N
--------------------
Y
G
TA
D
PIS
MQD
P
QY
G
NAN
I
N
-
INF------
-
--
P
YAVI----
N
RQE
QT
---G
LY
I
Q
D
QS
E
WNKW
V
L
T
L
GG
-
-
--
-
-
--
RYD
F
A
K
T
------------
STYTRSTSS
L
D
-----
EIND
Q
QF
TW
R
G
G
IN
Y
-
L
F
DNG
I
S
P
Y
F
SY
S
E
SF
E
-----
P
---------
V
S
-GA
---
T
K
E
G
KP
-
F
D
P
S
R
G
K
Q
YE
A
G
V
K
YVPK
D
T
P
V
TV
T
A
SV
F
Q
LTKD
K
NLT
--------
A
D
P
SNIL
FS
V
Q
G
G
EI
R
S
R
G
F
EIE
AK
---
A
A
L
N
A
NI
N
V
T
AA
Y
S
YTD
AE
YTKD
T
LY
K
G
K
RP
A
E
--------
V
P
R
N
MAS
LW
A
D
Y
TFR
E
T
A
LS
G
L
S
F
G
A
G
A
RY
F
G
DT
S
S
FYTTG
E
-
K
A
-
-
N
QT
F
NV
G
G
Y
T
L
VDA
MI
K
Y
D
L
A
R
F
GM
P
G
S
S
V
G
V
NVNNLFD
RE
YV
S
S
CYR
D
-
Y
-------
ACYW
GA
E
R
Q
V
VA
TAT
FR
F
fig|749531.3.peg.1749
Escherichia coli MS 69-1 (5-760/760)
RNFPARQFHSL
----
TF
F
AG
LCI
G
ITPV
AQA
L
AAE
GQA
NAD
DTL
V
VEAS
T
PSL
Y
APQQSA
----
----------
DP
K
FSR
P
VA
D
T
TRT
MTV
I
S
E
Q
V
I
K
DQ
G
AT
NL
T
D
AL
K
N
V
PGV
G
AFF
A
G
EN
G
N
S
T
T
G
D
A
I
Y
M
-
RG
AD
TSNS
I
--
-
-
YIDGI
RD
-------
I
GS
----
V
SR
D
TFNT
E
Q
VEVI
K
GP
S
G
TD
YG
R
SAP
T
G
S
INM
I
SK
Q
P
R
N
DSG
I
-
D
A
SA
SI
GS
AWFR
R
GTL
D
VNQA
I
G
D
TT
AV
R
L
N
V
M
G
-E
K
T
H
DA
GR
D
KIKN
ERY
GV
AP
SVA
F
G
LG
TANR
L
YLN
----------
Y
L
HVT
QH
NTP
D
GGI
PT
I
G
LP
G
YS
A
P
SA
GT
AALN
--
H
SGK
V
D
THNFYGT
D
S
DY
D
D
STT
D
TAT
MR
--------
FEH
D
I
ND
N
T
T
I
R
N
T
T
RWS
R
VK
Q
D
Y
LM
TA
I
M
G
G
A
S
NITQ
P
TSDVN
S
W-
--------
-----------TWS
R
TANTK
D
VSN
K
I
L
TN
QT
N
L
T
S
T
F
Y
TG
S
I
G
H
D
V
S
---------------
TGV
E
F
T
R
--
-
ETQ
T
N
--------------------
Y
G
VN
---
P
VTL
P
AV
N
IYH
PD
-
--------N
S
IH
P
GGLTRNGA
N
ANG
QT
DTFA
I
YA
F
D
TL
Q
ITRD
F
E
L
N
GG
I
R
LD
N
Y
HTE
YD
S
AT
A
CGGSGRGAITCP
AGVAKGSPV
T
T
VDT
--
AKSG
N
LV
N
W
K
AG
AL
Y
H
L
T
E
NG
-
N
V
Y
I
N
YA
V
S
Q
Q
-----
P
PGGNNFALA
Q
S
GSG
---
N
S
A
N
RT
D
F
K
P
Q
K
A
N
T
S
EIG
T
K
WQVL
D
K
RL
LL
T
A
ALFR
TDIE
N
EVE
--------
Q
N
D
D
GTY
SQ
Y
--
G
KK
R
V
E
G
Y
EI
S
VA
---
G
N
IT
P
AWQV
I
GGYT
QQK
A
-
----
T
IK
NG
K
DV
AQ
DGSSSLPY
T
PEH
AFT
LWS
Q
Y
QAT
D
-
-
--
D
IS
VG
A
G
A
RY
I
G
---
S
MHKGS
D
-
G
A
V
GT
PA
F
TE
G
-
Y
W
V
A
DA
KL
G
Y
R
V
N
R
----
N
L
D
F
QLNV
Y
NLFD
TD
YVAS
INK
S
G
Y
-------
RFHP
G
E
PR
T
F
LL
TA
N
MH
F
fig|656444.3.peg.1356
Escherichia coli TA280 (5-760/760)
RNFPARQFHSL
----
TF
F
AG
LCI
G
ITPV
AQA
L
AAE
GQA
NAD
DTL
V
VEAS
T
PSL
Y
APQQSA
----
----------
DP
K
FSR
P
VA
D
T
TRT
MTV
I
S
E
Q
V
I
K
DQ
G
AT
NL
T
D
AL
K
N
V
PGV
G
AFF
A
G
EN
G
N
S
T
T
G
D
A
I
Y
M
-
RG
AD
TSNS
I
--
-
-
YIDGI
RD
-------
I
GS
----
V
SR
D
TFNT
E
Q
VEVI
K
GP
S
G
TD
YG
R
SAP
T
G
S
INM
I
SK
Q
P
R
N
DSG
I
-
D
A
SA
SI
GS
AWFR
R
GTL
D
VNQA
I
G
D
TT
AV
R
L
N
V
M
G
-E
K
T
H
DA
GR
D
KIKN
ERY
GV
AP
SVA
F
G
LG
TANR
L
YLN
----------
Y
L
HVT
QH
NTP
D
GGI
PT
I
G
LP
G
YS
A
P
SA
GT
VALN
--
H
SGK
V
D
THNFYGT
D
S
DY
D
D
STT
D
TAT
MR
--------
FEH
D
I
ND
N
T
T
I
R
N
T
T
RWS
R
VK
Q
D
Y
LM
TA
I
M
G
G
A
S
NITQ
P
TSDVN
S
W-
--------
-----------TWS
R
TANTK
D
VSN
K
I
L
TN
QT
N
L
T
S
T
F
Y
TG
S
I
G
H
D
V
S
---------------
TGV
E
F
T
R
--
-
ETQ
T
N
--------------------
Y
G
VN
---
P
VTL
P
AV
N
IYH
PD
-
--------S
S
IH
P
GGLTRNGA
N
ANG
QT
DTFA
I
YA
F
D
TL
Q
ITRD
F
E
L
N
GG
I
R
LD
N
Y
HTE
YD
S
AT
A
CGGSGRGAITCP
AGVAKGSPV
T
T
VDT
--
AKSG
N
LV
N
W
K
AG
AL
Y
H
L
T
E
NG
-
N
V
Y
I
N
YA
V
S
Q
Q
-----
P
PGGNNFALA
Q
S
GSG
---
N
S
A
N
RT
D
F
K
P
Q
K
A
N
T
S
EIG
T
K
WQVL
D
K
RL
LL
T
A
ALFR
TDIE
N
EVE
--------
Q
N
D
D
GTY
SQ
Y
--
G
KK
R
V
E
G
Y
EI
S
VA
---
G
N
IT
P
AWQV
I
GGYT
QQK
A
-
----
T
IK
NG
K
DV
AQ
DGSSSLPY
T
PEH
AFT
LWS
Q
Y
QAT
D
-
-
--
D
IS
VG
A
G
A
RY
I
G
---
S
MHKGS
D
-
G
A
V
GT
PA
F
TE
G
-
Y
W
V
A
DA
KL
G
Y
R
V
N
R
----
N
L
D
F
QLNV
Y
NLFD
TD
YVAS
INK
S
G
Y
-------
RYHP
G
E
PR
T
F
LL
TA
N
MH
F
fig|550677.3.peg.2074
Escherichia coli B354 (5-760/760)
RNFPARQFHSL
----
TF
F
AG
LCI
G
ITPV
AQA
L
AAE
GQA
NAD
DTL
V
VEAS
T
PSL
Y
APQQSA
----
----------
DP
K
FSR
P
VA
D
T
TRT
MTV
I
S
E
Q
V
I
K
DQ
G
AT
NL
T
D
AL
K
N
V
PGV
G
AFF
A
G
EN
G
N
S
T
T
G
D
A
I
Y
M
-
RG
AD
TSNS
I
--
-
-
YIDGI
RD
-------
I
GS
----
V
SR
D
TFNT
E
Q
VEVI
K
GP
S
G
TD
YG
R
SAP
T
G
S
INM
I
SK
Q
P
R
N
DSG
I
-
D
A
SA
SI
GS
AWFR
R
GTL
D
VNQA
I
G
D
TT
AV
R
L
N
V
M
G
-E
K
T
H
DA
GR
D
KIKN
ERY
GV
AP
SVA
F
G
LG
TANR
L
YLN
----------
Y
L
HVT
QH
NTP
D
GGI
PT
I
G
LP
G
YS
A
P
SA
GT
AALN
--
H
SGK
V
D
THNFYGT
D
S
DY
D
D
STT
D
TAT
MR
--------
FEH
D
I
ND
N
T
T
I
R
N
T
T
RWS
R
VK
Q
D
Y
LM
TA
I
M
G
G
A
S
NITQ
P
TSDVN
S
W-
--------
-----------TWS
R
TANTK
D
VSN
K
I
L
TN
QT
N
L
T
S
T
F
Y
TG
S
I
G
H
D
V
S
---------------
TGV
E
F
T
R
--
-
ETQ
T
N
--------------------
Y
G
VN
---
P
VTL
P
AV
N
IYH
PD
-
--------N
S
IH
P
GGLTRNGA
N
ANG
QT
DTFA
I
YA
F
D
TL
Q
ITRD
F
E
L
N
GG
I
R
LD
N
Y
HTE
YD
S
AT
A
CGGSGRGAITCP
AGVAKGSPV
T
T
VDT
--
AKSG
N
LV
N
W
K
AG
AL
Y
H
L
T
E
NG
-
N
V
Y
I
N
YA
V
S
Q
Q
-----
P
PGGNNFALA
Q
S
GSG
---
N
S
A
N
RT
D
F
K
P
Q
K
A
N
T
S
EIG
T
K
WQVL
D
K
RL
LL
T
A
ALFR
TDIE
N
EVE
--------
Q
N
D
D
GTY
SQ
Y
--
G
KK
R
V
E
G
Y
EI
S
VA
---
G
N
IT
P
AWQV
I
GGYT
QQK
A
-
----
T
IK
NG
K
DV
AQ
DGSSSLPY
T
PEH
AFT
LWS
Q
Y
QAT
D
-
-
--
D
IS
VG
A
G
A
RY
I
G
---
S
MHKGS
D
-
G
A
V
GT
PA
F
TE
G
-
Y
W
V
A
D
T
KL
G
Y
R
V
N
R
----
N
L
D
F
QLNV
Y
NLFD
TD
YVAS
INK
S
G
Y
-------
RYHP
G
E
PR
T
F
LL
TA
N
MH
F
fig|679204.3.peg.5067
Escherichia coli MS 145-7 (5-760/760)
RNFPARQFHSL
----
TF
F
AG
LCI
G
ITPV
AQA
L
AAE
GQT
NAD
DTL
V
VEAS
T
PSL
Y
APQQSA
----
----------
DP
K
FSR
P
VA
D
T
TRT
MTV
I
S
E
Q
V
I
K
DQ
G
AT
NL
T
D
AL
K
N
V
PGV
G
AFF
A
G
EN
G
N
S
T
T
G
D
A
I
Y
M
-
RG
AD
TSNS
I
--
-
-
YIDGI
RD
-------
I
GS
----
V
SR
D
TFNT
E
Q
VEVI
K
GP
S
G
TD
YG
R
SAP
T
G
S
INM
I
SK
Q
P
R
N
DSG
I
-
D
A
SA
SI
GS
AWFR
R
GTL
D
VNQV
I
G
D
TT
AV
R
L
N
V
M
G
-E
K
T
H
DA
RR
D
KVKN
ERY
GV
AP
SIA
F
G
LG
TANR
L
YLN
----------
Y
L
HVT
QH
NTP
D
GGI
PT
I
G
LP
G
YS
A
P
SA
GT
AALN
--
H
SGK
V
D
THNFYGT
D
S
DY
D
D
STT
D
TAT
MR
--------
FEH
D
I
ND
N
T
T
I
R
N
T
T
RWS
R
VK
Q
D
Y
LM
TA
I
M
G
G
A
S
NITQ
P
TSDVN
S
W-
--------
-----------TWS
R
TANTK
D
VSN
K
I
L
TN
QT
N
L
T
S
T
F
Y
TG
S
I
G
H
D
V
S
---------------
TGV
E
F
T
R
--
-
ETQ
T
N
--------------------
Y
G
VN
---
P
VTL
P
AV
N
IYH
PD
-
--------S
S
IH
P
GGLTRNGA
N
ANG
QT
DTFA
I
YA
F
D
TL
Q
ITRD
F
E
L
N
GG
I
R
LD
N
Y
HTE
YD
S
AT
A
CGGSGRGAITCP
AGVAKGSPV
T
T
VDT
--
AKSG
N
LV
N
W
K
AG
AL
Y
H
L
T
E
NG
-
N
V
Y
I
N
YA
V
S
Q
Q
-----
P
PGGNNFALA
Q
S
GSG
---
N
S
A
N
RT
D
F
K
P
Q
K
A
N
T
S
EIG
T
K
WQVL
D
K
RL
LL
T
A
ALFR
TDIE
N
EVE
--------
Q
N
D
D
GTY
SQ
Y
--
G
KK
R
V
E
G
Y
EI
S
VA
---
G
N
IT
P
AWQV
I
GGYT
QQK
A
-
----
T
IK
NG
K
DV
AQ
DGSSSLPY
T
PEH
AFT
LWS
Q
Y
QAT
D
-
-
--
D
IS
VG
A
G
A
RY
I
G
---
S
MHKGS
D
-
G
A
V
GT
PA
F
TE
G
-
Y
W
V
A
DA
KL
G
Y
R
V
N
R
----
N
L
D
F
QLNV
Y
NLFD
TD
YVAS
INK
S
G
Y
-------
RYHP
G
E
PR
T
F
LL
TA
N
MH
F
fig|439855.10.peg.986
Escherichia coli SMS-3-5 (5-760/760)
RNFPARQFHSL
----
TF
F
AG
LCI
G
ITPV
AQA
L
AAE
GQI
NAD
DTL
V
VEAS
T
PSL
Y
APQQSA
----
----------
DP
K
FSR
P
VA
D
T
TRT
MTV
I
S
E
Q
V
I
K
DQ
G
AT
NL
T
D
AL
K
N
V
PGV
G
AFF
A
G
EN
G
N
S
T
T
G
D
A
I
Y
M
-
RG
AD
TSNS
I
--
-
-
YIDGI
RD
-------
I
GS
----
V
SR
D
TFNT
E
Q
VEVI
K
GP
S
G
TD
YG
R
SAP
T
G
S
INM
I
SK
Q
P
R
N
DSG
I
-
D
A
SA
SI
GS
AWFR
R
GTL
D
VNQV
I
G
D
TT
AV
R
L
N
V
M
G
-E
K
T
H
DA
GR
D
KVKN
ERY
GV
AP
SVA
F
G
LG
TANR
L
YLN
----------
Y
L
HVT
QH
NTP
D
GGI
PT
I
G
LP
G
YS
A
P
SA
GT
AALN
--
H
SGK
V
D
THNFYGT
D
S
DY
D
D
STT
D
TAT
MR
--------
FEH
D
I
ND
N
T
T
I
R
N
T
T
RWS
R
VK
Q
D
Y
LM
TA
I
M
G
G
A
S
NITQ
P
TSDVN
S
W-
--------
-----------TWS
R
TANTK
D
VSN
K
I
L
TN
QT
N
L
T
S
T
F
Y
TG
A
I
G
H
D
V
S
---------------
TGV
E
F
T
R
--
-
ETQ
T
N
--------------------
Y
G
VN
---
P
VTL
P
AV
N
IYH
PD
-
--------S
S
IH
P
GGLTRNGA
N
ANG
QT
DTFA
I
YA
F
D
TL
Q
ITRD
F
E
L
N
GG
I
R
LD
N
Y
HTE
YD
S
AT
A
CGGSGRGAITCP
AGVAKGSPV
T
T
VDT
--
ARSG
N
LV
N
W
K
AG
AL
Y
H
L
T
E
NG
-
N
V
Y
I
N
YA
V
S
Q
Q
-----
P
PGGNNFALA
Q
S
GSG
---
N
S
A
N
RT
D
F
K
P
Q
K
A
N
T
S
EIG
T
K
WQVL
D
K
RL
LL
T
A
ALFR
TDIE
N
EVE
--------
Q
N
D
D
GTY
SQ
Y
--
G
KK
R
V
E
G
Y
EI
S
GA
---
G
N
IT
P
AWQV
I
GGYT
QQK
A
-
----
T
IK
NG
K
DV
AQ
DGSSSLPY
T
PEH
AFT
LWS
Q
Y
QAT
D
-
-
--
D
IS
VG
A
G
A
RY
I
G
---
S
MHKGS
D
-
G
A
V
GT
PA
F
TE
G
-
Y
W
V
A
DA
KL
G
Y
R
V
N
R
----
N
L
D
F
QLNV
Y
NLFD
TD
YVAS
INK
S
G
Y
-------
RYHP
G
E
PR
T
F
LL
TA
N
MH
F
fig|550676.3.peg.267
Escherichia coli B185 (5-760/760)
RNFPARQFHSL
----
TF
F
AG
LCI
G
ITPV
AQA
L
AAE
GQT
NAD
DTL
V
VEAS
T
PSL
Y
APQQSA
----
----------
DP
K
FSR
P
VA
D
T
TRT
MTV
I
S
E
Q
V
I
K
DQ
G
AT
NL
T
D
AL
K
N
V
PGV
G
AFF
A
G
EN
G
N
S
T
T
G
D
A
I
Y
M
-
RG
AD
TSNS
I
--
-
-
YIDGI
RD
-------
I
GS
----
V
SR
D
TFNT
E
Q
VEVI
K
GP
S
G
TD
YG
R
SAP
T
G
S
INM
I
SK
Q
P
R
N
DSG
I
-
D
A
SA
SI
GS
AWFR
R
GTL
D
VNQV
I
G
D
TT
AV
R
L
N
V
M
G
-E
K
T
H
DA
GR
D
KVKN
ERY
GI
AP
SVA
F
G
LG
TANR
L
YLN
----------
Y
L
HVT
QH
NTP
D
GGI
PT
I
G
LP
G
YS
A
P
SA
GT
ATLN
--
H
SGK
V
D
THNFYGT
D
S
DY
D
D
STT
D
TAT
MR
--------
FEH
D
I
ND
N
T
T
I
R
N
T
T
RWS
R
VK
Q
D
Y
LM
TA
I
M
G
G
A
S
NITQ
P
TSDVN
S
W-
--------
-----------TWS
R
TANTK
D
VSN
K
I
L
TN
QT
N
L
T
S
T
F
Y
TG
S
I
G
H
D
V
S
---------------
TGV
E
F
T
R
--
-
ETQ
T
N
--------------------
Y
G
VN
---
P
VTL
P
AV
N
IYH
PD
-
--------S
S
IH
P
GGLTSNGA
N
ANG
QT
DTFA
I
YA
F
D
TL
Q
ITRD
F
E
L
N
GG
I
R
LD
N
Y
HTE
YD
S
AT
A
CGGSGRGAITCP
AGVAKGSPV
T
T
VDT
--
AKSG
N
LV
N
W
K
AG
AL
Y
H
L
T
E
NG
-
N
V
Y
I
N
YA
V
S
Q
Q
-----
P
PGGNNFALA
Q
S
GSG
---
N
S
A
N
RT
D
F
K
P
Q
K
A
N
T
S
EIG
T
K
WQVL
D
K
RL
LL
T
A
ALFR
TDIE
N
EVE
--------
Q
N
D
D
GTY
SQ
Y
--
G
KK
R
V
E
G
Y
EI
S
VA
---
G
N
IT
P
AWQV
I
GGYT
QQK
A
-
----
T
IK
NG
K
DV
AQ
DGSSSLPY
T
PEH
AFT
LWS
Q
Y
QAT
D
-
-
--
D
IS
VG
A
G
A
RY
I
G
---
S
MHKGS
D
-
G
A
V
GT
PA
F
TE
G
-
Y
W
V
A
DA
KL
G
Y
R
V
N
R
----
N
L
D
F
QLNV
Y
NLFD
TD
YVAS
INK
S
G
Y
-------
RYHP
G
E
PR
T
F
LL
TA
N
MH
F
fig|216592.1.peg.3331
Escherichia coli 042 (5-760/760)
RNFPARQFHSL
----
TF
F
AG
LCI
S
ITPV
AQA
L
AAE
GQA
NAD
DTL
V
VEAS
T
PSL
Y
APQQSA
----
----------
DP
K
FSR
P
VA
D
T
TRT
MTV
I
S
E
Q
V
I
K
DQ
G
AT
NL
T
D
AL
K
N
V
PGV
G
AFF
A
G
EN
G
N
S
T
T
G
D
A
I
Y
M
-
RG
AD
TSNS
I
--
-
-
YIDGI
RD
-------
I
GS
----
V
SR
D
TFNT
E
Q
VEVI
K
GP
S
G
TD
YG
R
SAP
T
G
S
INM
I
SK
Q
P
R
N
DSG
I
-
D
A
SA
SI
GS
AWFR
R
GTL
D
VNQV
I
G
D
TT
AV
R
L
N
V
M
G
-E
K
T
H
DA
GR
D
KVKN
ERY
GV
AP
SVA
F
G
LG
TANR
L
YLN
----------
Y
L
HVT
QH
NTP
D
GGI
PT
I
G
LP
G
YS
A
P
SA
GT
AALN
--
H
SGK
V
D
THNFYGT
D
S
DY
D
D
STT
D
TAT
MR
--------
FEH
D
I
ND
N
T
T
I
R
N
T
T
RWS
R
VK
Q
D
Y
LM
TA
I
M
G
G
A
S
NITQ
P
TSDVN
S
W-
--------
-----------TWS
R
TANTK
D
VSN
K
I
L
TN
QT
N
L
T
S
T
F
Y
TG
S
I
G
H
D
V
S
---------------
TGV
E
F
T
R
--
-
ETQ
T
N
--------------------
Y
G
VN
---
P
VTL
P
AV
N
IYH
PD
-
--------S
S
IH
P
GGLTRNGA
N
ANG
QT
DTFA
I
YA
F
D
TL
Q
ITRD
F
E
L
N
GG
I
R
LD
N
Y
HTE
YD
S
AT
A
CGGSGRGAITCP
AGMAKGSPV
T
T
VDT
--
AKSG
N
LV
N
W
K
AG
AL
Y
H
L
T
E
NG
-
N
V
Y
I
N
YA
V
S
Q
Q
-----
P
PGGNNFALA
Q
S
GSG
---
N
S
A
N
RT
D
F
K
P
Q
K
A
N
T
S
EIG
T
K
WQVL
D
K
RL
LL
T
A
ALFR
TDIE
N
EVE
--------
Q
N
D
D
GTY
SQ
Y
--
G
KK
R
V
E
G
Y
EI
S
VA
---
G
N
IT
P
AWQV
I
GGYT
QQK
A
-
----
T
IK
NG
K
DV
AQ
DGSSSLPY
T
PEH
AFT
LWS
Q
Y
QAT
D
-
-
--
D
IS
VG
A
G
A
RY
I
G
---
S
MHKGS
D
-
G
A
V
GT
PA
F
TE
G
-
Y
W
V
A
DA
KL
G
Y
R
V
N
R
----
N
L
D
F
QLNV
Y
NLFD
TD
YVAS
INK
S
G
Y
-------
RYHP
G
E
PR
T
F
LL
TA
N
MH
F
fig|358709.5.peg.3083
Escherichia coli 101-1 (5-760/760)
RNFPARQFHSL
----
TF
F
AG
LCI
G
ITPV
AQA
L
AAE
GQA
NAD
DTL
V
VEAS
T
PSL
Y
APQQSA
----
----------
DP
K
FSR
P
VA
D
T
TRT
MTV
I
S
E
Q
V
I
K
DQ
G
AT
NL
T
D
AL
K
N
V
PGV
G
AFF
A
G
EN
G
N
S
T
T
G
D
A
I
Y
M
-
RG
AD
TSNS
I
--
-
-
YIDGI
RD
-------
I
GS
----
V
SR
D
TFNT
E
Q
VEVI
K
GP
S
G
TD
YG
R
SAP
T
G
S
INM
I
SK
Q
P
R
N
DSG
I
-
D
A
SA
SI
GS
AWFR
R
GTL
D
VNQV
I
G
D
TT
AV
R
L
N
V
M
G
-E
K
T
H
DA
GR
D
KVKN
ERY
GV
AP
SVA
F
G
LG
TANR
L
YLN
----------
Y
L
HVT
QH
NTP
D
GGI
PT
I
G
LP
G
YS
A
P
SA
GT
AALN
--
H
SGK
V
D
THNFYGT
D
S
DY
D
D
STT
D
TAT
MR
--------
FEH
D
I
ND
N
T
T
I
R
N
T
T
RWS
R
VK
Q
D
Y
LM
TA
I
M
G
G
A
S
NITQ
P
TSDVN
S
W-
--------
-----------TWS
R
TANTK
D
VSN
K
I
L
TN
QT
N
L
T
S
T
F
Y
TG
S
I
G
H
D
V
S
---------------
TGV
E
F
T
R
--
-
ETQ
T
N
--------------------
Y
G
VN
---
P
VTL
P
AV
N
IYH
PD
-
--------S
S
IH
P
GGLTRNGA
N
ANG
QT
DTFA
I
YA
F
D
TL
Q
ITRD
F
E
L
N
GG
I
R
LD
N
Y
HTE
YD
S
AT
A
CGGSGRGAITCP
VGVAKGSPV
T
T
VDT
--
ARSG
N
LV
N
W
K
AG
AL
Y
H
L
T
E
NG
-
N
V
Y
I
N
YA
V
S
Q
Q
-----
P
PGGNNFALA
Q
S
GSG
---
N
S
A
N
RT
D
F
K
P
Q
K
A
N
T
S
EIG
T
K
WQVL
D
K
RL
LL
T
A
ALFR
TDIE
N
EVE
--------
Q
N
D
D
GTY
SQ
Y
--
G
KK
R
V
E
G
Y
EI
S
VA
---
G
N
IT
P
AWQV
I
GGYT
QQK
A
-
----
T
IK
NG
K
DV
AQ
DGSSSLPY
T
PEH
AFT
LWS
Q
Y
QAT
D
-
-
--
D
IS
VG
A
G
A
RY
I
G
---
S
MHKGS
D
-
G
A
V
GT
PA
F
TE
G
-
Y
W
V
A
DA
KL
G
Y
R
V
N
R
----
N
L
D
F
QLNV
Y
NLFD
TD
YVAS
INK
S
G
Y
-------
RYHP
G
E
PR
T
F
LL
TA
N
MH
F
fig|413997.3.peg.815
Escherichia coli B str. REL606 (5-760/760)
RNFPARQFHSL
----
TF
F
AG
LCI
G
ITPV
AQA
L
AAE
GQA
NAD
DTL
V
VEAS
T
PSL
Y
APQQSA
----
----------
DP
K
FSR
P
VA
D
T
TRT
MTV
I
S
E
Q
V
I
K
DQ
G
AT
NL
T
D
AL
K
N
V
PGV
G
AFF
A
G
EN
G
N
S
T
T
G
D
A
I
Y
M
-
RG
AD
TSNS
I
--
-
-
YIDGI
RD
-------
I
GS
----
V
SR
D
TFNT
E
Q
VEVI
K
GP
S
G
TD
YG
R
SAP
T
G
S
INM
I
SK
Q
P
R
N
DSG
I
-
D
A
SA
SI
GS
AWFR
R
GTL
D
VNQV
I
G
D
TT
AV
R
L
N
V
M
G
-E
K
T
H
DA
GR
D
KVKN
ERY
GV
AP
SVA
F
G
LG
TANR
L
YLN
----------
Y
L
HVT
QH
NTP
D
GGI
PT
I
G
LP
G
YS
A
P
SA
GT
AALN
--
H
SGK
V
D
THNFYGT
D
S
DY
D
D
STT
D
TAT
MR
--------
FEH
D
I
ND
N
T
T
I
R
N
T
T
RWS
R
VK
Q
D
Y
LM
TA
I
M
G
G
A
S
NITQ
P
TSDVN
S
W-
--------
-----------TWS
R
TANTK
D
VSN
K
I
L
TN
QT
N
L
T
S
T
F
Y
TG
S
I
G
H
D
V
S
---------------
TGV
E
F
T
R
--
-
ETQ
T
N
--------------------
Y
G
VN
---
P
VTL
P
AV
N
IYH
PD
-
--------S
S
IH
P
GGLTRNGA
N
ANG
QT
DTFA
I
YA
F
D
TL
Q
ITRD
F
E
L
N
GG
I
R
LD
N
Y
HTE
YD
S
AT
A
CGGSGRGAITCP
VGVAKGSPV
T
T
VDT
--
ARSG
N
LV
N
W
K
AG
AL
Y
H
L
T
E
NG
-
N
V
Y
I
N
YA
V
S
Q
Q
-----
P
PGGNNFALA
Q
S
GSG
---
N
S
A
N
RT
D
F
K
P
Q
K
A
N
T
S
EIG
T
K
WQVL
D
K
RL
LL
T
A
ALFR
TDIE
N
EVE
--------
Q
N
D
D
GTY
SQ
Y
--
G
KK
R
V
E
G
Y
EI
S
VA
---
G
N
IT
P
AWQV
I
GGYT
QQK
A
-
----
T
IK
NG
K
DV
AQ
DGSSSLPY
T
PEH
AFT
LWS
Q
Y
QAT
D
-
-
--
D
IS
VG
A
G
A
RY
I
G
---
S
MHKGS
D
-
G
A
V
GT
PA
F
TE
G
-
Y
W
V
A
DA
KL
G
Y
R
V
N
R
----
N
L
D
F
QLNV
Y
NLFD
TD
YVAS
INK
S
G
Y
-------
RYHP
G
E
PR
T
F
LL
TA
N
MH
F
fig|511693.5.peg.843
Escherichia coli BL21 (5-760/760)
RNFPARQFHSL
----
TF
F
AG
LCI
G
ITPV
AQA
L
AAE
GQA
NAD
DTL
V
VEAS
T
PSL
Y
APQQSA
----
----------
DP
K
FSR
P
VA
D
T
TRT
MTV
I
S
E
Q
V
I
K
DQ
G
AT
NL
T
D
AL
K
N
V
PGV
G
AFF
A
G
EN
G
N
S
T
T
G
D
A
I
Y
M
-
RG
AD
TSNS
I
--
-
-
YIDGI
RD
-------
I
GS
----
V
SR
D
TFNT
E
Q
VEVI
K
GP
S
G
TD
YG
R
SAP
T
G
S
INM
I
SK
Q
P
R
N
DSG
I
-
D
A
SA
SI
GS
AWFR
R
GTL
D
VNQV
I
G
D
TT
AV
R
L
N
V
M
G
-E
K
T
H
DA
GR
D
KVKN
ERY
GV
AP
SVA
F
G
LG
TANR
L
YLN
----------
Y
L
HVT
QH
NTP
D
GGI
PT
I
G
LP
G
YS
A
P
SA
GT
AALN
--
H
SGK
V
D
THNFYGT
D
S
DY
D
D
STT
D
TAT
MR
--------
FEH
D
I
ND
N
T
T
I
R
N
T
T
RWS
R
VK
Q
D
Y
LM
TA
I
M
G
G
A
S
NITQ
P
TSDVN
S
W-
--------
-----------TWS
R
TANTK
D
VSN
K
I
L
TN
QT
N
L
T
S
T
F
Y
TG
S
I
G
H
D
V
S
---------------
TGV
E
F
T
R
--
-
ETQ
T
N
--------------------
Y
G
VN
---
P
VTL
P
AV
N
IYH
PD
-
--------S
S
IH
P
GGLTRNGA
N
ANG
QT
DTFA
I
YA
F
D
TL
Q
ITRD
F
E
L
N
GG
I
R
LD
N
Y
HTE
YD
S
AT
A
CGGSGRGAITCP
VGVAKGSPV
T
T
VDT
--
ARSG
N
LV
N
W
K
AG
AL
Y
H
L
T
E
NG
-
N
V
Y
I
N
YA
V
S
Q
Q
-----
P
PGGNNFALA
Q
S
GSG
---
N
S
A
N
RT
D
F
K
P
Q
K
A
N
T
S
EIG
T
K
WQVL
D
K
RL
LL
T
A
ALFR
TDIE
N
EVE
--------
Q
N
D
D
GTY
SQ
Y
--
G
KK
R
V
E
G
Y
EI
S
VA
---
G
N
IT
P
AWQV
I
GGYT
QQK
A
-
----
T
IK
NG
K
DV
AQ
DGSSSLPY
T
PEH
AFT
LWS
Q
Y
QAT
D
-
-
--
D
IS
VG
A
G
A
RY
I
G
---
S
MHKGS
D
-
G
A
V
GT
PA
F
TE
G
-
Y
W
V
A
DA
KL
G
Y
R
V
N
R
----
N
L
D
F
QLNV
Y
NLFD
TD
YVAS
INK
S
G
Y
-------
RYHP
G
E
PR
T
F
LL
TA
N
MH
F
fig|469008.4.peg.2918
Escherichia coli BL21(DE3) (5-760/760)
RNFPARQFHSL
----
TF
F
AG
LCI
G
ITPV
AQA
L
AAE
GQA
NAD
DTL
V
VEAS
T
PSL
Y
APQQSA
----
----------
DP
K
FSR
P
VA
D
T
TRT
MTV
I
S
E
Q
V
I
K
DQ
G
AT
NL
T
D
AL
K
N
V
PGV
G
AFF
A
G
EN
G
N
S
T
T
G
D
A
I
Y
M
-
RG
AD
TSNS
I
--
-
-
YIDGI
RD
-------
I
GS
----
V
SR
D
TFNT
E
Q
VEVI
K
GP
S
G
TD
YG
R
SAP
T
G
S
INM
I
SK
Q
P
R
N
DSG
I
-
D
A
SA
SI
GS
AWFR
R
GTL
D
VNQV
I
G
D
TT
AV
R
L
N
V
M
G
-E
K
T
H
DA
GR
D
KVKN
ERY
GV
AP
SVA
F
G
LG
TANR
L
YLN
----------
Y
L
HVT
QH
NTP
D
GGI
PT
I
G
LP
G
YS
A
P
SA
GT
AALN
--
H
SGK
V
D
THNFYGT
D
S
DY
D
D
STT
D
TAT
MR
--------
FEH
D
I
ND
N
T
T
I
R
N
T
T
RWS
R
VK
Q
D
Y
LM
TA
I
M
G
G
A
S
NITQ
P
TSDVN
S
W-
--------
-----------TWS
R
TANTK
D
VSN
K
I
L
TN
QT
N
L
T
S
T
F
Y
TG
S
I
G
H
D
V
S
---------------
TGV
E
F
T
R
--
-
ETQ
T
N
--------------------
Y
G
VN
---
P
VTL
P
AV
N
IYH
PD
-
--------S
S
IH
P
GGLTRNGA
N
ANG
QT
DTFA
I
YA
F
D
TL
Q
ITRD
F
E
L
N
GG
I
R
LD
N
Y
HTE
YD
S
AT
A
CGGSGRGAITCP
VGVAKGSPV
T
T
VDT
--
ARSG
N
LV
N
W
K
AG
AL
Y
H
L
T
E
NG
-
N
V
Y
I
N
YA
V
S
Q
Q
-----
P
PGGNNFALA
Q
S
GSG
---
N
S
A
N
RT
D
F
K
P
Q
K
A
N
T
S
EIG
T
K
WQVL
D
K
RL
LL
T
A
ALFR
TDIE
N
EVE
--------
Q
N
D
D
GTY
SQ
Y
--
G
KK
R
V
E
G
Y
EI
S
VA
---
G
N
IT
P
AWQV
I
GGYT
QQK
A
-
----
T
IK
NG
K
DV
AQ
DGSSSLPY
T
PEH
AFT
LWS
Q
Y
QAT
D
-
-
--
D
IS
VG
A
G
A
RY
I
G
---
S
MHKGS
D
-
G
A
V
GT
PA
F
TE
G
-
Y
W
V
A
DA
KL
G
Y
R
V
N
R
----
N
L
D
F
QLNV
Y
NLFD
TD
YVAS
INK
S
G
Y
-------
RYHP
G
E
PR
T
F
LL
TA
N
MH
F
fig|749547.3.peg.1647
Escherichia coli MS 187-1 (5-760/760)
RNFPARQFHSL
----
TF
F
AG
LCI
G
ITPV
AQA
L
AAE
GQA
NAD
DTL
V
VEAS
T
PSL
Y
APQQSA
----
----------
DP
K
FSR
P
VA
D
T
TRT
MTV
I
S
E
Q
V
I
K
DQ
G
AT
NL
T
D
AL
K
N
V
PGV
G
AFF
A
G
EN
G
N
S
T
T
G
D
A
I
Y
M
-
RG
AD
TSNS
I
--
-
-
YIDGI
RD
-------
I
GS
----
V
SR
D
TFNT
E
Q
VEVI
K
GP
S
G
TD
YG
R
SAP
T
G
S
INM
I
SK
Q
P
R
N
DSG
I
-
D
A
SA
SI
GS
AWFR
R
GTL
D
VNQV
I
G
D
TT
AV
R
L
N
V
M
G
-E
K
T
H
DA
GR
D
KVKN
ERY
GV
AP
SVA
F
G
LG
TANR
L
YLN
----------
Y
L
HVT
QH
NTP
D
GGI
PT
I
G
LP
G
YS
A
P
SA
GT
AALN
--
H
SGK
V
D
THNFYGT
D
S
DY
D
D
STT
D
TAT
MR
--------
FEH
D
I
ND
N
T
T
I
R
N
T
T
RWS
R
VK
Q
D
Y
LM
TA
I
M
G
G
A
S
NITQ
P
TSDVN
S
W-
--------
-----------TWS
R
TANTK
D
VSN
K
I
L
TN
QT
N
L
T
S
T
F
Y
TG
S
I
G
H
D
V
S
---------------
TGV
E
F
T
R
--
-
ETQ
T
N
--------------------
Y
G
VN
---
P
VTL
P
AV
N
IYH
PD
-
--------S
S
IH
P
GGLTRNGA
N
ANG
QT
DTFA
I
YA
F
D
TL
Q
ITRD
F
E
L
N
GG
I
R
LD
N
Y
HTE
YD
S
AT
A
CGGSGRGAITCP
VGVAKGSPV
T
T
VDT
--
ARSG
N
LV
N
W
K
AG
AL
Y
H
L
T
E
NG
-
N
V
Y
I
N
YA
V
S
Q
Q
-----
P
PGGNNFALA
Q
S
GSG
---
N
S
A
N
RT
D
F
K
P
Q
K
A
N
T
S
EIG
T
K
WQVL
D
K
RL
LL
T
A
ALFR
TDIE
N
EVE
--------
Q
N
D
D
GTY
SQ
Y
--
G
KK
R
V
E
G
Y
EI
S
VA
---
G
N
IT
P
AWQV
I
GGYT
QQK
A
-
----
T
IK
NG
K
DV
AQ
DGSSSLPY
T
PEH
AFT
LWS
Q
Y
QAT
D
-
-
--
D
IS
VG
A
G
A
RY
I
G
---
S
MHKGS
D
-
G
A
V
GT
PA
F
TE
G
-
Y
W
V
A
DA
KL
G
Y
R
V
N
R
----
N
L
D
F
QLNV
Y
NLFD
TD
YVAS
INK
S
G
Y
-------
RYHP
G
E
PR
T
F
LL
TA
N
MH
F
fig|637912.3.peg.1061
Escherichia coli OP50 (5-760/760)
RNFPARQFHSL
----
TF
F
AG
LCI
G
ITPV
AQA
L
AAE
GQA
NAD
DTL
V
VEAS
T
PSL
Y
APQQSA
----
----------
DP
K
FSR
P
VA
D
T
TRT
MTV
I
S
E
Q
V
I
K
DQ
G
AT
NL
T
D
AL
K
N
V
PGV
G
AFF
A
G
EN
G
N
S
T
T
G
D
A
I
Y
M
-
RG
AD
TSNS
I
--
-
-
YIDGI
RD
-------
I
GS
----
V
SR
D
TFNT
E
Q
VEVI
K
GP
S
G
TD
YG
R
SAP
T
G
S
INM
I
SK
Q
P
R
N
DSG
I
-
D
A
SA
SI
GS
AWFR
R
GTL
D
VNQV
I
G
D
TT
AV
R
L
N
V
M
G
-E
K
T
H
DA
GR
D
KVKN
ERY
GV
AP
SVA
F
G
LG
TANR
L
YLN
----------
Y
L
HVT
QH
NTP
D
GGI
PT
I
G
LP
G
YS
A
P
SA
GT
AALN
--
H
SGK
V
D
THNFYGT
D
S
DY
D
D
STT
D
TAT
MR
--------
FEH
D
I
ND
N
T
T
I
R
N
T
T
RWS
R
VK
Q
D
Y
LM
TA
I
M
G
G
A
S
NITQ
P
TSDVN
S
W-
--------
-----------TWS
R
TANTK
D
VSN
K
I
L
TN
QT
N
L
T
S
T
F
Y
TG
S
I
G
H
D
V
S
---------------
TGV
E
F
T
R
--
-
ETQ
T
N
--------------------
Y
G
VN
---
P
VTL
P
AV
N
IYH
PD
-
--------S
S
IH
P
GGLTRNGA
N
ANG
QT
DTFA
I
YA
F
D
TL
Q
ITRD
F
E
L
N
GG
I
R
LD
N
Y
HTE
YD
S
AT
A
CGGSGRGAITCP
VGVAKGSPV
T
T
VDT
--
ARSG
N
LV
N
W
K
AG
AL
Y
H
L
T
E
NG
-
N
V
Y
I
N
YA
V
S
Q
Q
-----
P
PGGNNFALA
Q
S
GSG
---
N
S
A
N
RT
D
F
K
P
Q
K
A
N
T
S
EIG
T
K
WQVL
D
K
RL
LL
T
A
ALFR
TDIE
N
EVE
--------
Q
N
D
D
GTY
SQ
Y
--
G
KK
R
V
E
G
Y
EI
S
VA
---
G
N
IT
P
AWQV
I
GGYT
QQK
A
-
----
T
IK
NG
K
DV
AQ
DGSSSLPY
T
PEH
AFT
LWS
Q
Y
QAT
D
-
-
--
D
IS
VG
A
G
A
RY
I
G
---
S
MHKGS
D
-
G
A
V
GT
PA
F
TE
G
-
Y
W
V
A
DA
KL
G
Y
R
V
N
R
----
N
L
D
F
QLNV
Y
NLFD
TD
YVAS
INK
S
G
Y
-------
RYHP
G
E
PR
T
F
LL
TA
N
MH
F
fig|344601.3.peg.2534
Escherichia coli B171 (5-760/760)
RNFPARQFHSL
----
TF
F
AG
LCI
G
ITPV
AQA
L
AAE
GQT
NAD
DTL
V
VEAS
T
PSL
Y
APQQSA
----
----------
DP
K
FSR
P
VA
D
T
TRT
MTV
I
S
E
Q
V
I
K
DQ
G
AT
NL
T
D
AL
K
N
V
PGV
G
AFF
A
G
EN
G
N
S
T
T
G
D
A
I
Y
M
-
RG
AD
TSNS
I
--
-
-
YIDGI
RD
-------
I
GS
----
V
SR
D
TFNT
E
Q
VEVI
K
GP
S
G
TD
YG
R
SAP
T
G
S
INM
I
SK
Q
P
R
N
DSG
I
-
D
A
SA
SI
GS
AWFR
R
GTL
D
VNQV
I
G
D
TT
AV
R
L
N
V
M
G
-E
K
T
H
DA
GR
D
KVKN
ERY
GV
AP
SIA
F
G
LG
TANR
L
YLN
----------
Y
L
HVT
QH
NTP
D
GGI
PT
I
G
LP
G
YS
A
P
SA
GT
AALN
--
H
SGK
V
D
THNFYGT
D
S
DY
D
D
STT
D
TAT
MR
--------
FEH
D
I
ND
N
T
T
I
R
N
T
T
RWS
R
VK
Q
D
Y
LM
TA
I
M
G
G
A
S
NITQ
P
TSDVN
S
W-
--------
-----------TWS
R
TANTK
D
VSN
K
I
L
TN
QT
N
L
T
S
T
F
Y
TG
S
I
G
H
D
V
S
---------------
TGV
E
F
T
R
--
-
ETQ
T
N
--------------------
Y
G
VN
---
P
VTL
P
AV
N
IYH
PD
-
--------S
S
IH
P
GGLTRNGA
N
ANG
QT
DTFA
I
YA
F
D
TL
Q
ITRD
F
E
L
N
GG
I
R
LD
N
Y
HTE
YD
S
AT
A
CGGSGRGAITCP
AGVAKGSPV
T
T
VDT
--
AKSG
N
LV
N
W
K
AG
AL
Y
H
L
T
E
NG
-
N
V
Y
I
N
YA
V
S
Q
Q
-----
P
PGGNNFALA
Q
S
GSG
---
N
S
A
N
RT
D
F
K
P
Q
K
A
N
T
S
EIG
T
K
WQVL
D
K
RL
LL
T
A
ALFR
TDIE
N
EVE
--------
Q
N
D
D
GTY
SQ
Y
--
G
KK
R
V
E
G
Y
EI
S
VA
---
G
N
IT
P
AWQV
I
GGYT
QQK
A
-
----
T
IK
NG
K
DV
AQ
DGSSSLPY
T
PEH
AFT
LWS
Q
Y
QAT
D
-
-
--
D
IS
VG
A
G
A
RY
I
G
---
S
MHKGS
D
-
G
A
V
GT
PA
F
TE
G
-
Y
W
V
A
DA
KL
G
Y
R
V
N
R
----
N
L
D
F
QLNV
Y
NLFD
TD
YVAS
INK
S
G
Y
-------
RYHP
G
E
PR
T
F
LL
TA
N
MH
F
fig|340185.3.peg.2852
Escherichia coli E22 (5-760/760)
RNFPARQFHSL
----
TF
F
AG
LCI
G
ITPV
AQA
L
AAE
GQT
NAD
DTL
V
VEAS
T
PSL
Y
APQQSA
----
----------
DP
K
FSR
P
VA
D
T
TRT
MTV
I
S
E
Q
V
I
K
DQ
G
AT
NL
T
D
AL
K
N
V
PGV
G
AFF
A
G
EN
G
N
S
T
T
G
D
A
I
Y
M
-
RG
AD
TSNS
I
--
-
-
YIDGI
RD
-------
I
GS
----
V
SR
D
TFNT
E
Q
VEVI
K
GP
S
G
TD
YG
R
SAP
T
G
S
INM
I
SK
Q
P
R
N
DSG
I
-
D
A
SA
SI
GS
AWFR
R
GTL
D
VNQV
I
G
D
TT
AV
R
L
N
V
M
G
-E
K
T
H
DA
GR
D
KVKN
ERY
GV
AP
SIA
F
G
LG
TANR
L
YLN
----------
Y
L
HVT
QH
NTP
D
GGI
PT
I
G
LP
G
YS
A
P
SA
GT
AALN
--
H
SGK
V
D
THNFYGT
D
S
DY
D
D
STT
D
TAT
MR
--------
FEH
D
I
ND
N
T
T
I
R
N
T
T
RWS
R
VK
Q
D
Y
LM
TA
I
M
G
G
A
S
NITQ
P
TSDVN
S
W-
--------
-----------TWS
R
TANTK
D
VSN
K
I
L
TN
QT
N
L
T
S
T
F
Y
TG
S
I
G
H
D
V
S
---------------
TGV
E
F
T
R
--
-
ETQ
T
N
--------------------
Y
G
VN
---
P
MTL
P
AV
N
IYH
PD
-
--------S
S
IH
P
GGLTRNGA
N
ANG
QT
DTFA
I
YA
F
D
TL
Q
ITRD
F
E
L
N
GG
I
R
LD
N
Y
HTE
YD
S
AT
A
CGGSGRGAITCP
AGVAKGSPV
T
T
VDT
--
AKSG
N
LV
N
W
K
AG
AL
Y
H
L
T
E
NG
-
N
V
Y
I
N
YA
V
S
Q
Q
-----
P
PGGNNFALA
Q
S
GSG
---
N
S
A
N
RT
D
F
K
P
Q
K
A
N
T
S
EIG
T
K
WQVL
D
K
RL
LL
T
A
ALFR
TDIE
N
EVE
--------
Q
N
D
D
GTY
SQ
Y
--
G
KK
R
V
E
G
Y
EI
S
VA
---
G
N
IT
P
AWQV
I
GGYT
QQK
A
-
----
T
IK
NG
K
DV
AQ
DGSSSLPY
T
PEH
AFT
LWS
Q
Y
QAT
D
-
-
--
D
IS
VG
A
G
A
RY
I
G
---
S
MHKGS
D
-
G
A
V
GT
PA
F
TE
G
-
Y
W
V
A
DA
KL
G
Y
R
V
N
R
----
N
L
D
F
QLNV
Y
NLFD
TD
YVAS
INK
S
G
Y
-------
RYHP
G
E
PR
T
F
LL
TA
N
MH
F
fig|331111.12.peg.1164
Escherichia coli E24377A (5-760/760)
RNFPARQFHSL
----
TF
F
AG
LCI
G
ITPV
AQA
L
AAE
GQT
NAD
DTL
V
VEAS
T
PSL
Y
APQQSA
----
----------
DP
K
FSR
P
VA
D
T
TRT
MTV
I
S
E
Q
V
I
K
DQ
G
AT
NL
T
D
AL
K
N
V
PGV
G
AFF
A
G
EN
G
N
S
T
T
G
D
A
I
Y
M
-
RG
AD
TSNS
I
--
-
-
YIDGI
RD
-------
I
GS
----
V
SR
D
TFNT
E
Q
VEVI
K
GP
S
G
TD
YG
R
SAP
T
G
S
INM
I
SK
Q
P
R
N
DSG
I
-
D
A
SA
SI
GS
AWFR
R
GTL
D
VNQV
I
G
D
TT
AV
R
L
N
V
M
G
-E
K
T
H
DA
GR
D
KVKN
ERY
GV
AP
SIA
F
G
LG
TANR
L
YLN
----------
Y
L
HVT
QH
NTP
D
GGI
PT
I
G
LP
G
YS
A
P
SA
GT
AALN
--
H
SGK
V
D
THNFYGT
D
S
DY
D
D
STT
D
TAT
MR
--------
FEH
D
I
ND
N
T
T
I
R
N
T
T
RWS
R
VK
Q
D
Y
LM
TA
I
M
G
G
A
S
NITQ
P
TSDVN
S
W-
--------
-----------TWS
R
TANTK
D
VSN
K
I
L
TN
QT
N
L
T
S
T
F
Y
TG
S
I
G
H
D
V
S
---------------
TGV
E
F
T
R
--
-
ETQ
T
N
--------------------
Y
G
VN
---
P
VTL
P
AV
N
IYH
PD
-
--------S
S
IH
P
GGLTRNGA
N
ANG
QT
DTFA
I
YA
F
D
TL
Q
ITRD
F
E
L
N
GG
I
R
LD
N
Y
HTE
YD
S
AT
A
CGGSGRGAITCP
AGVAKGSPV
T
T
VDT
--
AKSG
N
LV
N
W
K
AG
AL
Y
H
L
T
E
NG
-
N
V
Y
I
N
YA
V
S
Q
Q
-----
P
PGGNNFALA
Q
S
GSG
---
N
S
A
N
RT
D
F
K
P
Q
K
A
N
T
S
EIG
T
K
WQVL
D
K
RL
LL
T
A
ALFR
TDIE
N
EVE
--------
Q
N
D
D
GTY
SQ
Y
--
G
KK
R
V
E
G
Y
EI
S
VA
---
G
N
IT
P
AWQV
I
GGYT
QQK
A
-
----
T
IK
NG
K
DV
AQ
DGSSSLPY
T
PEH
AFT
LWS
Q
Y
QAT
D
-
-
--
D
IS
VG
A
G
A
RY
I
G
---
S
MHKGS
D
-
G
A
V
GT
PA
F
TE
G
-
Y
W
V
A
DA
KL
G
Y
R
V
N
R
----
N
L
D
F
QLNV
Y
NLFD
TD
YVAS
INK
S
G
Y
-------
RYHP
G
E
PR
T
F
LL
TA
N
MH
F
fig|331111.3.peg.3373
Escherichia coli E24377A (5-760/760)
RNFPARQFHSL
----
TF
F
AG
LCI
G
ITPV
AQA
L
AAE
GQT
NAD
DTL
V
VEAS
T
PSL
Y
APQQSA
----
----------
DP
K
FSR
P
VA
D
T
TRT
MTV
I
S
E
Q
V
I
K
DQ
G
AT
NL
T
D
AL
K
N
V
PGV
G
AFF
A
G
EN
G
N
S
T
T
G
D
A
I
Y
M
-
RG
AD
TSNS
I
--
-
-
YIDGI
RD
-------
I
GS
----
V
SR
D
TFNT
E
Q
VEVI
K
GP
S
G
TD
YG
R
SAP
T
G
S
INM
I
SK
Q
P
R
N
DSG
I
-
D
A
SA
SI
GS
AWFR
R
GTL
D
VNQV
I
G
D
TT
AV
R
L
N
V
M
G
-E
K
T
H
DA
GR
D
KVKN
ERY
GV
AP
SIA
F
G
LG
TANR
L
YLN
----------
Y
L
HVT
QH
NTP
D
GGI
PT
I
G
LP
G
YS
A
P
SA
GT
AALN
--
H
SGK
V
D
THNFYGT
D
S
DY
D
D
STT
D
TAT
MR
--------
FEH
D
I
ND
N
T
T
I
R
N
T
T
RWS
R
VK
Q
D
Y
LM
TA
I
M
G
G
A
S
NITQ
P
TSDVN
S
W-
--------
-----------TWS
R
TANTK
D
VSN
K
I
L
TN
QT
N
L
T
S
T
F
Y
TG
S
I
G
H
D
V
S
---------------
TGV
E
F
T
R
--
-
ETQ
T
N
--------------------
Y
G
VN
---
P
VTL
P
AV
N
IYH
PD
-
--------S
S
IH
P
GGLTRNGA
N
ANG
QT
DTFA
I
YA
F
D
TL
Q
ITRD
F
E
L
N
GG
I
R
LD
N
Y
HTE
YD
S
AT
A
CGGSGRGAITCP
AGVAKGSPV
T
T
VDT
--
AKSG
N
LV
N
W
K
AG
AL
Y
H
L
T
E
NG
-
N
V
Y
I
N
YA
V
S
Q
Q
-----
P
PGGNNFALA
Q
S
GSG
---
N
S
A
N
RT
D
F
K
P
Q
K
A
N
T
S
EIG
T
K
WQVL
D
K
RL
LL
T
A
ALFR
TDIE
N
EVE
--------
Q
N
D
D
GTY
SQ
Y
--
G
KK
R
V
E
G
Y
EI
S
VA
---
G
N
IT
P
AWQV
I
GGYT
QQK
A
-
----
T
IK
NG
K
DV
AQ
DGSSSLPY
T
PEH
AFT
LWS
Q
Y
QAT
D
-
-
--
D
IS
VG
A
G
A
RY
I
G
---
S
MHKGS
D
-
G
A
V
GT
PA
F
TE
G
-
Y
W
V
A
DA
KL
G
Y
R
V
N
R
----
N
L
D
F
QLNV
Y
NLFD
TD
YVAS
INK
S
G
Y
-------
RYHP
G
E
PR
T
F
LL
TA
N
MH
F
fig|595495.4.peg.3218
Escherichia coli KO11 (5-760/760)
RNFPARQFHSL
----
TF
F
AG
LCI
G
ITPV
AQA
L
AAE
GQT
NAD
DTL
V
VEAS
T
PSL
Y
APQQSA
----
----------
DP
K
FSR
P
VA
D
T
TRT
MTV
I
S
E
Q
V
I
K
DQ
G
AT
NL
T
D
AL
K
N
V
PGV
G
AFF
A
G
EN
G
N
S
T
T
G
D
A
I
Y
M
-
RG
AD
TSNS
I
--
-
-
YIDGI
RD
-------
I
GS
----
V
SR
D
TFNT
E
Q
VEVI
K
GP
S
G
TD
YG
R
SAP
T
G
S
INM
I
SK
Q
P
R
N
DSG
I
-
D
A
SA
SI
GS
AWFR
R
GTL
D
VNQV
I
G
D
TT
AV
R
L
N
V
M
G
-E
K
T
H
DA
GR
D
KVKN
ERY
GV
AP
SIA
F
G
LG
TANR
L
YLN
----------
Y
L
HVT
QH
NTP
D
GGI
PT
I
G
LP
G
YS
A
P
SA
GT
AALN
--
H
SGK
V
D
THNFYGT
D
S
DY
D
D
STT
D
TAT
MR
--------
FEH
D
I
ND
N
T
T
I
R
N
T
T
RWS
R
VK
Q
D
Y
LM
TA
I
M
G
G
A
S
NITQ
P
TSDVN
S
W-
--------
-----------TWS
R
TANTK
D
VSN
K
I
L
TN
QT
N
L
T
S
T
F
Y
TG
S
I
G
H
D
V
S
---------------
TGV
E
F
T
R
--
-
ETQ
T
N
--------------------
Y
G
VN
---
P
VTL
P
AV
N
IYH
PD
-
--------S
S
IH
P
GGLTRNGA
N
ANG
QT
DTFA
I
YA
F
D
TL
Q
ITRD
F
E
L
N
GG
I
R
LD
N
Y
HTE
YD
S
AT
A
CGGSGRGAITCP
AGVAKGSPV
T
T
VDT
--
AKSG
N
LV
N
W
K
AG
AL
Y
H
L
T
E
NG
-
N
V
Y
I
N
YA
V
S
Q
Q
-----
P
PGGNNFALA
Q
S
GSG
---
N
S
A
N
RT
D
F
K
P
Q
K
A
N
T
S
EIG
T
K
WQVL
D
K
RL
LL
T
A
ALFR
TDIE
N
EVE
--------
Q
N
D
D
GTY
SQ
Y
--
G
KK
R
V
E
G
Y
EI
S
VA
---
G
N
IT
P
AWQV
I
GGYT
QQK
A
-
----
T
IK
NG
K
DV
AQ
DGSSSLPY
T
PEH
AFT
LWS
Q
Y
QAT
D
-
-
--
D
IS
VG
A
G
A
RY
I
G
---
S
MHKGS
D
-
G
A
V
GT
PA
F
TE
G
-
Y
W
V
A
DA
KL
G
Y
R
V
N
R
----
N
L
D
F
QLNV
Y
NLFD
TD
YVAS
INK
S
G
Y
-------
RYHP
G
E
PR
T
F
LL
TA
N
MH
F
fig|656419.3.peg.1088
Escherichia coli M718 (5-760/760)
RNFPARQFHSL
----
TF
F
AG
LCI
G
ITPV
AQA
L
AAE
GQT
NAD
DTL
V
VEAS
T
PSL
Y
APQQSA
----
----------
DP
K
FSR
P
VA
D
T
TRT
MTV
I
S
E
Q
V
I
K
DQ
G
AT
NL
T
D
AL
K
N
V
PGV
G
AFF
A
G
EN
G
N
S
T
T
G
D
A
I
Y
M
-
RG
AD
TSNS
I
--
-
-
YIDGI
RD
-------
I
GS
----
V
SR
D
TFNT
E
Q
VEVI
K
GP
S
G
TD
YG
R
SAP
T
G
S
INM
I
SK
Q
P
R
N
DSG
I
-
D
A
SA
SI
GS
AWFR
R
GTL
D
VNQV
I
G
D
TT
AV
R
L
N
V
M
G
-E
K
T
H
DA
GR
D
KVKN
ERY
GV
AP
SVA
F
G
LG
TANR
L
YLN
----------
Y
L
HVT
QH
NTP
D
GGI
PT
I
G
LP
G
YS
A
P
SA
GT
ATLN
--
H
SGK
V
D
THNFYGT
D
S
DY
D
D
STT
D
TAT
MR
--------
FEH
D
I
ND
N
T
T
I
R
N
T
T
RWS
R
VK
Q
D
Y
LM
TA
I
M
G
G
A
S
NITQ
P
TSDVN
S
W-
--------
-----------TWS
R
TANTK
D
VSN
K
I
L
TN
QT
N
L
T
S
T
F
Y
TG
S
I
G
H
D
V
S
---------------
TGV
E
F
T
R
--
-
ETQ
T
N
--------------------
Y
G
VN
---
P
VTL
P
AV
N
IYH
PD
-
--------S
S
IH
P
GGLTRNGA
N
ANG
QT
DTFA
I
YA
F
D
TL
Q
ITRD
F
E
L
N
GG
I
R
LD
N
Y
HTE
YD
S
AT
A
CGGSGRGAITCP
AGVAKGSPV
T
T
VDT
--
AKSG
N
LV
N
W
K
AG
AL
Y
H
L
T
E
NG
-
N
V
Y
I
N
YA
V
S
Q
Q
-----
P
PGGNNFALA
Q
S
GSG
---
N
S
A
N
RT
D
F
K
P
Q
K
A
N
T
S
EIG
T
K
WQVL
D
K
RL
LL
T
A
ALFR
TDIE
N
EVE
--------
Q
N
D
D
GTY
SQ
Y
--
G
KK
R
V
E
G
Y
EI
S
VA
---
G
N
IT
P
AWQV
I
GGYT
QQK
A
-
----
T
IK
NG
K
DV
AQ
DGSSSLPY
T
PEH
AFT
LWS
Q
Y
QAT
D
-
-
--
D
IS
VG
A
G
A
RY
I
G
---
S
MHKGS
D
-
G
A
V
GT
PA
F
TE
G
-
Y
W
V
A
DA
KL
G
Y
R
V
N
R
----
N
L
D
F
QLNV
Y
NLFD
TD
YVAS
INK
S
G
Y
-------
RYHP
G
E
PR
T
F
LL
TA
N
MH
F
fig|679207.4.peg.1463
Escherichia coli MS 107-1 (5-760/760)
RNFPARQFHSL
----
TF
F
AG
LCI
G
ITPV
AQA
L
AAE
GQT
NAD
DTL
V
VEAS
T
PSL
Y
APQQSA
----
----------
DP
K
FSR
P
VA
D
T
TRT
MTV
I
S
E
Q
V
I
K
DQ
G
AT
NL
T
D
AL
K
N
V
PGV
G
AFF
A
G
EN
G
N
S
T
T
G
D
A
I
Y
M
-
RG
AD
TSNS
I
--
-
-
YIDGI
RD
-------
I
GS
----
V
SR
D
TFNT
E
Q
VEVI
K
GP
S
G
TD
YG
R
SAP
T
G
S
INM
I
SK
Q
P
R
N
DSG
I
-
D
A
SA
SI
GS
AWFR
R
GTL
D
VNQV
I
G
D
TT
AV
R
L
N
V
M
G
-E
K
T
H
DA
GR
D
KVKN
ERY
GV
AP
SIA
F
G
LG
TANR
L
YLN
----------
Y
L
HVT
QH
NTP
D
GGI
PT
I
G
LP
G
YS
A
P
SA
GT
AALN
--
H
SGK
V
D
THNFYGT
D
S
DY
D
D
STT
D
TAT
MR
--------
FEH
D
I
ND
N
T
T
I
R
N
T
T
RWS
R
VK
Q
D
Y
LM
TA
I
M
G
G
A
S
NITQ
P
TSDVN
S
W-
--------
-----------TWS
R
TANTK
D
VSN
K
I
L
TN
QT
N
L
T
S
T
F
Y
TG
S
I
G
H
D
V
S
---------------
TGV
E
F
T
R
--
-
ETQ
T
N
--------------------
Y
G
VN
---
P
VTL
P
AV
N
IYH
PD
-
--------S
S
IH
P
GGLTRNGA
N
ANG
QT
DTFA
I
YA
F
D
TL
Q
ITRD
F
E
L
N
GG
I
R
LD
N
Y
HTE
YD
S
AT
A
CGGSGRGAITCP
AGVAKGSPV
T
T
VDT
--
AKSG
N
LV
N
W
K
AG
AL
Y
H
L
T
E
NG
-
N
V
Y
I
N
YA
V
S
Q
Q
-----
P
PGGNNFALA
Q
S
GSG
---
N
S
A
N
RT
D
F
K
P
Q
K
A
N
T
S
EIG
T
K
WQVL
D
K
RL
LL
T
A
ALFR
TDIE
N
EVE
--------
Q
N
D
D
GTY
SQ
Y
--
G
KK
R
V
E
G
Y
EI
S
VA
---
G
N
IT
P
AWQV
I
GGYT
QQK
A
-
----
T
IK
NG
K
DV
AQ
DGSSSLPY
T
PEH
AFT
LWS
Q
Y
QAT
D
-
-
--
D
IS
VG
A
G
A
RY
I
G
---
S
MHKGS
D
-
G
A
V
GT
PA
F
TE
G
-
Y
W
V
A
DA
KL
G
Y
R
V
N
R
----
N
L
D
F
QLNV
Y
NLFD
TD
YVAS
INK
S
G
Y
-------
RYHP
G
E
PR
T
F
LL
TA
N
MH
F
fig|749545.3.peg.1000
Escherichia coli MS 182-1 (5-760/760)
RNFPARQFHSL
----
TF
F
AG
LCI
G
ITPV
AQA
L
AAE
GQT
NAD
DTL
V
VEAS
T
PSL
Y
APQQSA
----
----------
DP
K
FSR
P
VA
D
T
TRT
MTV
I
S
E
Q
V
I
K
DQ
G
AT
NL
T
D
AL
K
N
V
PGV
G
AFF
A
G
EN
G
N
S
T
T
G
D
A
I
Y
M
-
RG
AD
TSNS
I
--
-
-
YIDGI
RD
-------
I
GS
----
V
SR
D
TFNT
E
Q
VEVI
K
GP
S
G
TD
YG
R
SAP
T
G
S
INM
I
SK
Q
P
R
N
DSG
I
-
D
A
SA
SI
GS
AWFR
R
GTL
D
VNQV
I
G
D
TT
AV
R
L
N
V
M
G
-E
K
T
H
DA
GR
D
KVKN
ERY
GV
AP
SIA
F
G
LG
TANR
L
YLN
----------
Y
L
HVT
QH
NTP
D
GGI
PT
I
G
LP
G
YS
A
P
SA
GT
AALN
--
H
SGK
V
D
THNFYGT
D
S
DY
D
D
STT
D
TAT
MR
--------
FEH
D
I
ND
N
T
T
I
R
N
T
T
RWS
R
VK
Q
D
Y
LM
TA
I
M
G
G
A
S
NITQ
P
TSDVN
S
W-
--------
-----------TWS
R
TANTK
D
VSN
K
I
L
TN
QT
N
L
T
S
T
F
Y
TG
S
I
G
H
D
V
S
---------------
TGV
E
F
T
R
--
-
ETQ
T
N
--------------------
Y
G
VN
---
P
VTL
P
AV
N
IYH
PD
-
--------S
S
IH
P
GGLTRNGA
N
ANG
QT
DTFA
I
YA
F
D
TL
Q
ITRD
F
E
L
N
GG
I
R
LD
N
Y
HTE
YD
S
AT
A
CGGSGRGAITCP
AGVAKGSPV
T
T
VDT
--
AKSG
N
LV
N
W
K
AG
AL
Y
H
L
T
E
NG
-
N
V
Y
I
N
YA
V
S
Q
Q
-----
P
PGGNNFALA
Q
S
GSG
---
N
S
A
N
RT
D
F
K
P
Q
K
A
N
T
S
EIG
T
K
WQVL
D
K
RL
LL
T
A
ALFR
TDIE
N
EVE
--------
Q
N
D
D
GTY
SQ
Y
--
G
KK
R
V
E
G
Y
EI
S
VA
---
G
N
IT
P
AWQV
I
GGYT
QQK
A
-
----
T
IK
NG
K
DV
AQ
DGSSSLPY
T
PEH
AFT
LWS
Q
Y
QAT
D
-
-
--
D
IS
VG
A
G
A
RY
I
G
---
S
MHKGS
D
-
G
A
V
GT
PA
F
TE
G
-
Y
W
V
A
DA
KL
G
Y
R
V
N
R
----
N
L
D
F
QLNV
Y
NLFD
TD
YVAS
INK
S
G
Y
-------
RYHP
G
E
PR
T
F
LL
TA
N
MH
F
fig|749532.3.peg.2677
Escherichia coli MS 78-1 (5-760/760)
RNFPARQFHSL
----
TF
F
AG
LCI
G
ITPV
AQA
L
AAE
GQT
NAD
DTL
V
VEAS
T
PSL
Y
APQQSA
----
----------
DP
K
FSR
P
VA
D
T
TRT
MTV
I
S
E
Q
V
I
K
DQ
G
AT
NL
T
D
AL
K
N
V
PGV
G
AFF
A
G
EN
G
N
S
T
T
G
D
A
I
Y
M
-
RG
AD
TSNS
I
--
-
-
YIDGI
RD
-------
I
GS
----
V
SR
D
TFNT
E
Q
VEVI
K
GP
S
G
TD
YG
R
SAP
T
G
S
INM
I
SK
Q
P
R
N
DSG
I
-
D
A
SA
SI
GS
AWFR
R
GTL
D
VNQV
I
G
D
TT
AV
R
L
N
V
M
G
-E
K
T
H
DA
GR
D
KVKN
ERY
GV
AP
SIA
F
G
LG
TANR
L
YLN
----------
Y
L
HVT
QH
NTP
D
GGI
PT
I
G
LP
G
YS
A
P
SA
GT
AALN
--
H
SGK
V
D
THNFYGT
D
S
DY
D
D
STT
D
TAT
MR
--------
FEH
D
I
ND
N
T
T
I
R
N
T
T
RWS
R
VK
Q
D
Y
LM
TA
I
M
G
G
A
S
NITQ
P
TSDVN
S
W-
--------
-----------TWS
R
TANTK
D
VSN
K
I
L
TN
QT
N
L
T
S
T
F
Y
TG
S
I
G
H
D
V
S
---------------
TGV
E
F
T
R
--
-
ETQ
T
N
--------------------
Y
G
VN
---
P
VTL
P
AV
N
IYH
PD
-
--------S
S
IH
P
GGLTRNGA
N
ANG
QT
DTFA
I
YA
F
D
TL
Q
ITRD
F
E
L
N
GG
I
R
LD
N
Y
HTE
YD
S
AT
A
CGGSGRGAITCP
AGVAKGSPV
T
T
VDT
--
AKSG
N
LV
N
W
K
AG
AL
Y
H
L
T
E
NG
-
N
V
Y
I
N
YA
V
S
Q
Q
-----
P
PGGNNFALA
Q
S
GSG
---
N
S
A
N
RT
D
F
K
P
Q
K
A
N
T
S
EIG
T
K
WQVL
D
K
RL
LL
T
A
ALFR
TDIE
N
EVE
--------
Q
N
D
D
GTY
SQ
Y
--
G
KK
R
V
E
G
Y
EI
S
VA
---
G
N
IT
P
AWQV
I
GGYT
QQK
A
-
----
T
IK
NG
K
DV
AQ
DGSSSLPY
T
PEH
AFT
LWS
Q
Y
QAT
D
-
-
--
D
IS
VG
A
G
A
RY
I
G
---
S
MHKGS
D
-
G
A
V
GT
PA
F
TE
G
-
Y
W
V
A
DA
KL
G
Y
R
V
N
R
----
N
L
D
F
QLNV
Y
NLFD
TD
YVAS
INK
S
G
Y
-------
RYHP
G
E
PR
T
F
LL
TA
N
MH
F
fig|409438.11.peg.987
Escherichia coli SE11 (5-760/760)
RNFPARQFHSL
----
TF
F
AG
LCI
G
ITPV
AQA
L
AAE
GQT
NAD
DTL
V
VEAS
T
PSL
Y
APQQSA
----
----------
DP
K
FSR
P
VA
D
T
TRT
MTV
I
S
E
Q
V
I
K
DQ
G
AT
NL
T
D
AL
K
N
V
PGV
G
AFF
A
G
EN
G
N
S
T
T
G
D
A
I
Y
M
-
RG
AD
TSNS
I
--
-
-
YIDGI
RD
-------
I
GS
----
V
SR
D
TFNT
E
Q
VEVI
K
GP
S
G
TD
YG
R
SAP
T
G
S
INM
I
SK
Q
P
R
N
DSG
I
-
D
A
SA
SI
GS
AWFR
R
GTL
D
VNQV
I
G
D
TT
AV
R
L
N
V
M
G
-E
K
T
H
DA
GR
D
KVKN
ERY
GV
AP
SIA
F
G
LG
TANR
L
YLN
----------
Y
L
HVT
QH
NTP
D
GGI
PT
I
G
LP
G
YS
A
P
SA
GT
AALN
--
H
SGK
V
D
THNFYGT
D
S
DY
D
D
STT
D
TAT
MR
--------
FEH
D
I
ND
N
T
T
I
R
N
T
T
RWS
R
VK
Q
D
Y
LM
TA
I
M
G
G
A
S
NITQ
P
TSDVN
S
W-
--------
-----------TWS
R
TANTK
D
VSN
K
I
L
TN
QT
N
L
T
S
T
F
Y
TG
S
I
G
H
D
V
S
---------------
TGV
E
F
T
R
--
-
ETQ
T
N
--------------------
Y
G
VN
---
P
VTL
P
AV
N
IYH
PD
-
--------S
S
IH
P
GGLTRNGA
N
ANG
QT
DTFA
I
YA
F
D
TL
Q
ITRD
F
E
L
N
GG
I
R
LD
N
Y
HTE
YD
S
AT
A
CGGSGRGAITCP
AGVAKGSPV
T
T
VDT
--
AKSG
N
LV
N
W
K
AG
AL
Y
H
L
T
E
NG
-
N
V
Y
I
N
YA
V
S
Q
Q
-----
P
PGGNNFALA
Q
S
GSG
---
N
S
A
N
RT
D
F
K
P
Q
K
A
N
T
S
EIG
T
K
WQVL
D
K
RL
LL
T
A
ALFR
TDIE
N
EVE
--------
Q
N
D
D
GTY
SQ
Y
--
G
KK
R
V
E
G
Y
EI
S
VA
---
G
N
IT
P
AWQV
I
GGYT
QQK
A
-
----
T
IK
NG
K
DV
AQ
DGSSSLPY
T
PEH
AFT
LWS
Q
Y
QAT
D
-
-
--
D
IS
VG
A
G
A
RY
I
G
---
S
MHKGS
D
-
G
A
V
GT
PA
F
TE
G
-
Y
W
V
A
DA
KL
G
Y
R
V
N
R
----
N
L
D
F
QLNV
Y
NLFD
TD
YVAS
INK
S
G
Y
-------
RYHP
G
E
PR
T
F
LL
TA
N
MH
F
fig|566546.3.peg.3760
Escherichia coli W (5-760/760)
RNFPARQFHSL
----
TF
F
AG
LCI
G
ITPV
AQA
L
AAE
GQT
NAD
DTL
V
VEAS
T
PSL
Y
APQQSA
----
----------
DP
K
FSR
P
VA
D
T
TRT
MTV
I
S
E
Q
V
I
K
DQ
G
AT
NL
T
D
AL
K
N
V
PGV
G
AFF
A
G
EN
G
N
S
T
T
G
D
A
I
Y
M
-
RG
AD
TSNS
I
--
-
-
YIDGI
RD
-------
I
GS
----
V
SR
D
TFNT
E
Q
VEVI
K
GP
S
G
TD
YG
R
SAP
T
G
S
INM
I
SK
Q
P
R
N
DSG
I
-
D
A
SA
SI
GS
AWFR
R
GTL
D
VNQV
I
G
D
TT
AV
R
L
N
V
M
G
-E
K
T
H
DA
GR
D
KVKN
ERY
GV
AP
SIA
F
G
LG
TANR
L
YLN
----------
Y
L
HVT
QH
NTP
D
GGI
PT
I
G
LP
G
YS
A
P
SA
GT
AALN
--
H
SGK
V
D
THNFYGT
D
S
DY
D
D
STT
D
TAT
MR
--------
FEH
D
I
ND
N
T
T
I
R
N
T
T
RWS
R
VK
Q
D
Y
LM
TA
I
M
G
G
A
S
NITQ
P
TSDVN
S
W-
--------
-----------TWS
R
TANTK
D
VSN
K
I
L
TN
QT
N
L
T
S
T
F
Y
TG
S
I
G
H
D
V
S
---------------
TGV
E
F
T
R
--
-
ETQ
T
N
--------------------
Y
G
VN
---
P
VTL
P
AV
N
IYH
PD
-
--------S
S
IH
P
GGLTRNGA
N
ANG
QT
DTFA
I
YA
F
D
TL
Q
ITRD
F
E
L
N
GG
I
R
LD
N
Y
HTE
YD
S
AT
A
CGGSGRGAITCP
AGVAKGSPV
T
T
VDT
--
AKSG
N
LV
N
W
K
AG
AL
Y
H
L
T
E
NG
-
N
V
Y
I
N
YA
V
S
Q
Q
-----
P
PGGNNFALA
Q
S
GSG
---
N
S
A
N
RT
D
F
K
P
Q
K
A
N
T
S
EIG
T
K
WQVL
D
K
RL
LL
T
A
ALFR
TDIE
N
EVE
--------
Q
N
D
D
GTY
SQ
Y
--
G
KK
R
V
E
G
Y
EI
S
VA
---
G
N
IT
P
AWQV
I
GGYT
QQK
A
-
----
T
IK
NG
K
DV
AQ
DGSSSLPY
T
PEH
AFT
LWS
Q
Y
QAT
D
-
-
--
D
IS
VG
A
G
A
RY
I
G
---
S
MHKGS
D
-
G
A
V
GT
PA
F
TE
G
-
Y
W
V
A
DA
KL
G
Y
R
V
N
R
----
N
L
D
F
QLNV
Y
NLFD
TD
YVAS
INK
S
G
Y
-------
RYHP
G
E
PR
T
F
LL
TA
N
MH
F
fig|566546.4.peg.854
Escherichia coli W (5-760/760)
RNFPARQFHSL
----
TF
F
AG
LCI
G
ITPV
AQA
L
AAE
GQT
NAD
DTL
V
VEAS
T
PSL
Y
APQQSA
----
----------
DP
K
FSR
P
VA
D
T
TRT
MTV
I
S
E
Q
V
I
K
DQ
G
AT
NL
T
D
AL
K
N
V
PGV
G
AFF
A
G
EN
G
N
S
T
T
G
D
A
I
Y
M
-
RG
AD
TSNS
I
--
-
-
YIDGI
RD
-------
I
GS
----
V
SR
D
TFNT
E
Q
VEVI
K
GP
S
G
TD
YG
R
SAP
T
G
S
INM
I
SK
Q
P
R
N
DSG
I
-
D
A
SA
SI
GS
AWFR
R
GTL
D
VNQV
I
G
D
TT
AV
R
L
N
V
M
G
-E
K
T
H
DA
GR
D
KVKN
ERY
GV
AP
SIA
F
G
LG
TANR
L
YLN
----------
Y
L
HVT
QH
NTP
D
GGI
PT
I
G
LP
G
YS
A
P
SA
GT
AALN
--
H
SGK
V
D
THNFYGT
D
S
DY
D
D
STT
D
TAT
MR
--------
FEH
D
I
ND
N
T
T
I
R
N
T
T
RWS
R
VK
Q
D
Y
LM
TA
I
M
G
G
A
S
NITQ
P
TSDVN
S
W-
--------
-----------TWS
R
TANTK
D
VSN
K
I
L
TN
QT
N
L
T
S
T
F
Y
TG
S
I
G
H
D
V
S
---------------
TGV
E
F
T
R
--
-
ETQ
T
N
--------------------
Y
G
VN
---
P
VTL
P
AV
N
IYH
PD
-
--------S
S
IH
P
GGLTRNGA
N
ANG
QT
DTFA
I
YA
F
D
TL
Q
ITRD
F
E
L
N
GG
I
R
LD
N
Y
HTE
YD
S
AT
A
CGGSGRGAITCP
AGVAKGSPV
T
T
VDT
--
AKSG
N
LV
N
W
K
AG
AL
Y
H
L
T
E
NG
-
N
V
Y
I
N
YA
V
S
Q
Q
-----
P
PGGNNFALA
Q
S
GSG
---
N
S
A
N
RT
D
F
K
P
Q
K
A
N
T
S
EIG
T
K
WQVL
D
K
RL
LL
T
A
ALFR
TDIE
N
EVE
--------
Q
N
D
D
GTY
SQ
Y
--
G
KK
R
V
E
G
Y
EI
S
VA
---
G
N
IT
P
AWQV
I
GGYT
QQK
A
-
----
T
IK
NG
K
DV
AQ
DGSSSLPY
T
PEH
AFT
LWS
Q
Y
QAT
D
-
-
--
D
IS
VG
A
G
A
RY
I
G
---
S
MHKGS
D
-
G
A
V
GT
PA
F
TE
G
-
Y
W
V
A
DA
KL
G
Y
R
V
N
R
----
N
L
D
F
QLNV
Y
NLFD
TD
YVAS
INK
S
G
Y
-------
RYHP
G
E
PR
T
F
LL
TA
N
MH
F
fig|585057.6.peg.825
Escherichia coli IAI39 (5-760/760)
RNFPARQFHSL
----
TF
F
AG
LCI
G
ITPV
AQA
L
AAE
GQT
NAD
DTL
V
VEAS
T
PSL
Y
APQQSA
----
----------
DP
K
FSR
P
VA
D
T
TRT
MTV
I
S
E
Q
V
I
K
DQ
G
AT
NL
T
D
AL
K
N
V
PGV
G
AFF
A
G
EN
G
N
S
T
T
G
D
A
I
Y
M
-
RG
AD
TSNS
I
--
-
-
YIDGI
RD
-------
I
GS
----
V
SR
D
TFNT
E
Q
VEVI
K
GP
S
G
TD
YG
R
SAP
T
G
S
INM
I
SK
Q
P
R
N
DSG
I
-
D
A
SA
SI
GS
AWFR
R
GTL
D
VNQV
I
G
D
TT
AV
R
L
N
V
M
G
-E
K
T
H
DA
GR
D
KVKN
ERY
GV
AP
SVA
F
G
LG
TANR
L
YLN
----------
Y
L
HVT
QH
NTP
D
GGI
PT
I
G
LP
G
YS
A
P
SA
GT
AALN
--
H
SGK
V
D
THNFYGT
D
S
DY
D
D
STT
D
TAT
MR
--------
FEH
D
I
ND
N
T
T
I
R
N
T
T
RWS
R
VK
Q
D
Y
LM
TA
I
M
G
G
A
S
NITQ
P
TSDVN
S
W-
--------
-----------TWS
R
TANTK
D
VSN
K
I
L
TN
QT
N
L
T
S
T
F
Y
TG
S
I
G
H
D
V
S
---------------
TGV
E
F
T
R
--
-
ETQ
T
N
--------------------
Y
G
VN
---
P
VTL
P
AV
N
IYH
PD
-
--------S
S
IH
P
GGLTRNGA
N
ANG
QT
DTFA
I
YA
F
D
TL
Q
ITRD
F
E
L
N
GG
I
R
LD
N
Y
HTE
YD
S
AT
A
CGGSGRGAITCP
AGVAKGSPV
T
T
VDT
--
AKSG
N
LV
N
W
K
AG
AL
Y
H
L
T
E
NG
-
N
I
Y
I
N
YA
V
S
Q
Q
-----
P
PGGNNFALA
Q
S
GSG
---
N
S
A
N
RT
D
F
K
P
Q
K
A
N
T
S
EIG
T
K
WQVL
D
K
RL
LL
T
A
ALFR
TDIE
N
EVE
--------
Q
N
D
D
GTY
SQ
Y
--
G
KK
R
V
E
G
Y
EI
S
VA
---
G
N
IT
P
AWQV
I
GGYT
QQK
A
-
----
T
IK
NG
K
DV
AQ
DGSSSLPY
T
PEH
AFT
LWS
Q
Y
QAT
D
-
-
--
D
IS
VG
A
G
A
RY
I
G
---
S
MHKGS
D
-
G
A
V
GT
PA
F
TE
G
-
Y
W
V
A
DA
KL
G
Y
R
V
N
R
----
N
L
D
F
QLNV
Y
NLFD
TD
YVAS
INK
S
G
Y
-------
RYHP
G
E
PR
T
F
LL
TA
N
MH
F
fig|749527.3.peg.4375
Escherichia coli MS 21-1 (5-760/760)
RNFPARQFHSL
----
TF
F
AG
LCI
G
ITPV
AQA
L
AAE
GQT
N
V
D
DTL
V
VEAS
T
PSL
Y
APQQSA
----
----------
DP
K
FSR
P
VA
D
T
TRT
MTV
I
S
E
Q
V
I
K
DQ
G
AT
NL
T
D
AL
K
N
V
PGV
G
AFF
A
G
EN
G
N
S
T
T
G
D
A
I
Y
M
-
RG
AD
TSNS
I
--
-
-
YIDGI
RD
-------
I
GS
----
V
SR
D
TFNT
E
Q
VEVI
K
GP
S
G
TD
YG
R
SAP
T
G
S
INM
I
SK
Q
P
R
N
DSG
I
-
D
A
SA
SI
GS
AWFR
R
GTL
D
VNQV
I
G
D
TT
AV
R
L
N
V
M
G
-E
K
T
H
DA
GR
D
KVKN
ERY
GV
AP
SVA
F
G
LG
TANR
L
YLN
----------
Y
L
HVT
QH
NTP
D
GGI
PT
I
G
LP
G
YS
A
P
SA
GT
AALN
--
H
SGK
V
D
THNFYGT
D
S
DY
D
D
STT
D
TAT
MR
--------
FEH
D
I
ND
N
T
T
I
R
N
T
T
RWS
R
VK
Q
D
Y
LM
TA
I
M
G
G
A
S
NITQ
P
TSDVN
S
W-
--------
-----------TWS
R
TANTK
D
VSN
K
I
L
TN
QT
N
L
T
S
T
F
Y
TG
S
I
G
H
D
V
S
---------------
TGV
E
F
T
R
--
-
ETQ
T
N
--------------------
Y
G
VN
---
P
VTL
P
AV
N
IYH
PD
-
--------S
S
IH
P
GGLTRNGA
N
ANG
QT
DTFA
I
YA
F
D
TL
Q
ITRD
F
E
L
N
GG
I
R
LD
N
Y
HTE
YD
S
AT
A
CGGSGRGAITCP
AGVAKGSPV
T
T
VDT
--
AKSG
N
LV
N
W
K
AG
AL
Y
H
L
T
E
NG
-
N
I
Y
I
N
YA
V
S
Q
Q
-----
P
PGGNNFALA
Q
S
GSG
---
N
S
A
N
RT
D
F
K
P
Q
K
A
N
T
S
EIG
T
K
WQVL
D
K
RL
LL
T
A
ALFR
TDIE
N
EVE
--------
Q
N
D
D
GTY
SQ
Y
--
G
KK
R
V
E
G
Y
EI
S
VA
---
G
N
IT
P
AWQV
I
GGYT
QQK
A
-
----
T
IK
NG
K
DV
AQ
DGSSSLPY
T
PEH
AFT
LWS
Q
Y
QAT
D
-
-
--
D
IS
VG
A
G
A
RY
I
G
---
S
MHKGS
D
-
G
A
V
GT
PA
F
TE
G
-
Y
W
V
A
DA
KL
G
Y
R
V
N
R
----
N
L
D
F
QLNV
Y
NLFD
TD
YVAS
INK
S
G
Y
-------
RYHP
G
E
PR
T
F
LL
TA
N
MH
F
fig|656379.3.peg.1641
Escherichia coli FVEC1302 (5-760/760)
RNFPARQFHSL
----
TF
F
AG
LCI
G
ITPV
AQA
L
AAE
GQA
NAD
DTL
V
VEAS
T
PSL
Y
APQQSA
----
----------
DP
K
FSR
P
VA
D
T
TRT
MTV
I
S
E
Q
V
I
K
DQ
G
AT
NL
T
D
AL
K
N
V
PGV
G
AFF
A
G
EN
G
N
S
T
T
G
D
A
I
Y
M
-
RG
AD
TSNS
I
--
-
-
YIDGI
RD
-------
I
GS
----
V
SR
D
TFNT
E
Q
VEVI
K
GP
S
G
TD
YG
R
SAP
T
G
S
INM
I
SK
Q
P
R
N
DSG
I
-
D
A
SA
SI
GS
AWFR
R
GTL
D
VNQV
I
G
D
TT
AV
R
L
N
V
M
G
-E
K
T
H
DA
GR
D
KIKN
ERY
GV
AP
SVA
F
G
LG
TANR
L
YLN
----------
Y
L
HVT
QH
NTP
D
GGI
PT
I
G
LP
G
YS
A
P
SA
GT
AALN
--
H
SGK
V
D
THNFYGT
D
S
DY
D
D
STT
D
TAT
MR
--------
FEH
D
I
ND
N
T
T
I
R
N
T
T
RWS
R
VK
Q
D
Y
LM
TA
I
M
G
G
A
S
NITQ
P
TSDVN
S
W-
--------
-----------TWS
R
TANTK
D
VSN
K
I
L
TN
QT
N
L
T
S
T
F
Y
TG
S
I
G
H
D
V
S
---------------
TGV
E
F
T
R
--
-
ETQ
T
N
--------------------
Y
G
VN
---
P
VTL
P
AV
N
IYH
PD
-
--------S
S
IH
P
GGLTRNGA
N
ANG
QT
DTFA
I
YA
F
D
TL
Q
ITRD
F
E
L
N
GG
I
R
LD
N
Y
HTE
YD
S
AT
A
CGGSGRGAITCP
AGMAKGSPV
T
T
VDT
--
AKSG
N
LV
N
W
K
AG
AL
Y
H
L
T
E
NG
-
N
V
Y
I
N
YA
V
S
Q
Q
-----
P
PGGNNFALA
Q
S
GSG
---
N
S
A
N
RT
D
F
K
P
Q
K
A
N
T
S
EIG
T
K
WQVL
D
K
RL
LL
T
A
ALFR
TDIE
N
EVE
--------
Q
N
D
D
GTY
SQ
Y
--
G
KK
R
V
E
G
Y
EI
S
VA
---
G
N
IT
P
AWQV
I
GGYT
QQK
A
-
----
T
IK
NG
K
DV
AQ
DGSSSLPY
T
PEH
AFT
LWS
Q
Y
QAT
D
-
-
--
D
IS
VG
A
G
A
RY
I
G
---
S
MHKGS
D
-
G
A
V
GT
PA
F
TE
G
-
Y
W
V
A
DA
KL
G
Y
R
V
N
R
----
N
L
D
F
QLNV
Y
NLFD
TD
YVAS
INK
S
G
Y
-------
RYHP
G
E
PR
T
F
LL
TA
N
MH
F
fig|656380.3.peg.1469
Escherichia coli FVEC1412 (5-760/760)
RNFPARQFHSL
----
TF
F
AG
LCI
G
ITPV
AQA
L
AAE
GQA
NAD
DTL
V
VEAS
T
PSL
Y
APQQSA
----
----------
DP
K
FSR
P
VA
D
T
TRT
MTV
I
S
E
Q
V
I
K
DQ
G
AT
NL
T
D
AL
K
N
V
PGV
G
AFF
A
G
EN
G
N
S
T
T
G
D
A
I
Y
M
-
RG
AD
TSNS
I
--
-
-
YIDGI
RD
-------
I
GS
----
V
SR
D
TFNT
E
Q
VEVI
K
GP
S
G
TD
YG
R
SAP
T
G
S
INM
I
SK
Q
P
R
N
DSG
I
-
D
A
SA
SI
GS
AWFR
R
GTL
D
VNQV
I
G
D
TT
AV
R
L
N
V
M
G
-E
K
T
H
DA
GR
D
KIKN
ERY
GV
AP
SVA
F
G
LG
TANR
L
YLN
----------
Y
L
HVT
QH
NTP
D
GGI
PT
I
G
LP
G
YS
A
P
SA
GT
AALN
--
H
SGK
V
D
THNFYGT
D
S
DY
D
D
STT
D
TAT
MR
--------
FEH
D
I
ND
N
T
T
I
R
N
T
T
RWS
R
VK
Q
D
Y
LM
TA
I
M
G
G
A
S
NITQ
P
TSDVN
S
W-
--------
-----------TWS
R
TANTK
D
VSN
K
I
L
TN
QT
N
L
T
S
T
F
Y
TG
S
I
G
H
D
V
S
---------------
TGV
E
F
T
R
--
-
ETQ
T
N
--------------------
Y
G
VN
---
P
VTL
P
AV
N
IYH
PD
-
--------S
S
IH
P
GGLTRNGA
N
ANG
QT
DTFA
I
YA
F
D
TL
Q
ITRD
F
E
L
N
GG
I
R
LD
N
Y
HTE
YD
S
AT
A
CGGSGRGAITCP
AGMAKGSPV
T
T
VDT
--
AKSG
N
LV
N
W
K
AG
AL
Y
H
L
T
E
NG
-
N
V
Y
I
N
YA
V
S
Q
Q
-----
P
PGGNNFALA
Q
S
GSG
---
N
S
A
N
RT
D
F
K
P
Q
K
A
N
T
S
EIG
T
K
WQVL
D
K
RL
LL
T
A
ALFR
TDIE
N
EVE
--------
Q
N
D
D
GTY
SQ
Y
--
G
KK
R
V
E
G
Y
EI
S
VA
---
G
N
IT
P
AWQV
I
GGYT
QQK
A
-
----
T
IK
NG
K
DV
AQ
DGSSSLPY
T
PEH
AFT
LWS
Q
Y
QAT
D
-
-
--
D
IS
VG
A
G
A
RY
I
G
---
S
MHKGS
D
-
G
A
V
GT
PA
F
TE
G
-
Y
W
V
A
DA
KL
G
Y
R
V
N
R
----
N
L
D
F
QLNV
Y
NLFD
TD
YVAS
INK
S
G
Y
-------
RYHP
G
E
PR
T
F
LL
TA
N
MH
F
fig|749549.3.peg.2321
Escherichia coli MS 198-1 (5-760/760)
RNFPARQFHSL
----
TF
F
AG
LCI
G
ITPV
AQA
L
AAE
GQA
NAD
DTL
V
VEAS
T
PSL
Y
APQQSA
----
----------
DP
K
FSR
P
VA
D
T
TRT
MTV
I
S
E
Q
V
I
K
DQ
G
AT
NL
T
D
AL
K
N
V
PGV
G
AFF
A
G
EN
G
N
S
T
T
G
D
A
I
Y
M
-
RG
AD
TSNS
I
--
-
-
YIDGI
RD
-------
I
GS
----
V
SR
D
TFNT
E
Q
VEVI
K
GP
S
G
TD
YG
R
SAP
T
G
S
INM
I
SK
Q
P
R
N
DSG
I
-
D
A
SA
SI
GS
AWFR
R
GTL
D
VNQV
I
G
D
TT
AV
R
L
N
V
M
G
-E
K
T
H
DA
GR
D
KIKN
ERY
GV
AP
SVA
F
G
LG
TANR
L
YLN
----------
Y
L
HVT
QH
NTP
D
GGI
PT
I
G
LP
G
YS
A
P
SA
GT
AALN
--
H
SGK
V
D
THNFYGT
D
S
DY
D
D
STT
D
TAT
MR
--------
FEH
D
I
ND
N
T
T
I
R
N
T
T
RWS
R
VK
Q
D
Y
LM
TA
I
M
G
G
A
S
NITQ
P
TSDVN
S
W-
--------
-----------TWS
R
TANTK
D
VSN
K
I
L
TN
QT
N
L
T
S
T
F
Y
TG
S
I
G
H
D
V
S
---------------
TGV
E
F
T
R
--
-
ETQ
T
N
--------------------
Y
G
VN
---
P
VTL
P
AV
N
IYH
PD
-
--------S
S
IH
P
GGLTRNGA
N
ANG
QT
DTFA
I
YA
F
D
TL
Q
ITRD
F
E
L
N
GG
I
R
LD
N
Y
HTE
YD
S
AT
A
CGGSGRGAITCP
AGMAKGSPV
T
T
VDT
--
AKSG
N
LV
N
W
K
AG
AL
Y
H
L
T
E
NG
-
N
V
Y
I
N
YA
V
S
Q
Q
-----
P
PGGNNFALA
Q
S
GSG
---
N
S
A
N
RT
D
F
K
P
Q
K
A
N
T
S
EIG
T
K
WQVL
D
K
RL
LL
T
A
ALFR
TDIE
N
EVE
--------
Q
N
D
D
GTY
SQ
Y
--
G
KK
R
V
E
G
Y
EI
S
VA
---
G
N
IT
P
AWQV
I
GGYT
QQK
A
-
----
T
IK
NG
K
DV
AQ
DGSSSLPY
T
PEH
AFT
LWS
Q
Y
QAT
D
-
-
--
D
IS
VG
A
G
A
RY
I
G
---
S
MHKGS
D
-
G
A
V
GT
PA
F
TE
G
-
Y
W
V
A
DA
KL
G
Y
R
V
N
R
----
N
L
D
F
QLNV
Y
NLFD
TD
YVAS
INK
S
G
Y
-------
RYHP
G
E
PR
T
F
LL
TA
N
MH
F
fig|656437.3.peg.886
Escherichia coli TA143 (5-760/760)
RNFPARQFHSL
----
TF
F
AG
LCI
G
ITPV
AQA
L
AAE
GQA
NAD
DTL
V
VEAS
T
PSL
Y
APQQSA
----
----------
DP
K
FSR
P
VA
D
T
TRT
MTV
I
S
E
Q
V
I
K
DQ
G
AT
NL
T
D
AL
K
N
V
PGV
G
AFF
A
G
EN
G
N
S
T
T
G
D
A
I
Y
M
-
RG
AD
TSNS
I
--
-
-
YIDGI
RD
-------
I
GS
----
V
SR
D
TFNT
E
Q
VEVI
K
GP
S
G
TD
YG
R
SAP
T
G
S
INM
I
SK
Q
P
R
N
DSG
I
-
D
A
SA
SI
GS
AWFR
R
GTL
D
VNQV
I
G
D
TT
AV
R
L
N
V
M
G
-E
K
T
H
DA
GR
D
KIKN
ERY
GV
AP
SVA
F
G
LG
TANR
L
YLN
----------
Y
L
HVT
QH
NTP
D
GGI
PT
I
G
LP
G
YS
A
P
SA
GT
AALN
--
H
SGK
V
D
THNFYGT
D
S
DY
D
D
STT
D
TAT
MR
--------
FEH
D
I
ND
N
T
T
I
R
N
T
T
RWS
R
VK
Q
D
Y
LM
TA
I
M
G
G
A
S
NITQ
P
TSDVN
S
W-
--------
-----------TWS
R
TANTK
D
VSN
K
I
L
TN
QT
N
L
T
S
T
F
Y
TG
S
I
G
H
D
V
S
---------------
TGV
E
F
T
R
--
-
ETQ
T
N
--------------------
Y
G
VN
---
P
VTL
P
AV
N
IYH
PD
-
--------S
S
IH
P
GGLTRNGA
N
ANG
QT
DTFA
I
YA
F
D
TL
Q
ITRD
F
E
L
N
GG
I
R
LD
N
Y
HTE
YD
S
AT
A
CGGSGRGAITCP
AGMAKGSPV
T
T
VDT
--
AKSG
N
LV
N
W
K
AG
AL
Y
H
L
T
E
NG
-
N
V
Y
I
N
YA
V
S
Q
Q
-----
P
PGGNNFALA
Q
S
GSG
---
N
S
A
N
RT
D
F
K
P
Q
K
A
N
T
S
EIG
T
K
WQVL
D
K
RL
LL
T
A
ALFR
TDIE
N
EVE
--------
Q
N
D
D
GTY
SQ
Y
--
G
KK
R
V
E
G
Y
EI
S
VA
---
G
N
IT
P
AWQV
I
GGYT
QQK
A
-
----
T
IK
NG
K
DV
AQ
DGSSSLPY
T
PEH
AFT
LWS
Q
Y
QAT
D
-
-
--
D
IS
VG
A
G
A
RY
I
G
---
S
MHKGS
D
-
G
A
V
GT
PA
F
TE
G
-
Y
W
V
A
DA
KL
G
Y
R
V
N
R
----
N
L
D
F
QLNV
Y
NLFD
TD
YVAS
INK
S
G
Y
-------
RYHP
G
E
PR
T
F
LL
TA
N
MH
F
fig|585056.7.peg.1144
Escherichia coli UMN026 (5-760/760)
RNFPARQFHSL
----
TF
F
AG
LCI
G
ITPV
AQA
L
AAE
GQA
NAD
DTL
V
VEAS
T
PSL
Y
APQQSA
----
----------
DP
K
FSR
P
VA
D
T
TRT
MTV
I
S
E
Q
V
I
K
DQ
G
AT
NL
T
D
AL
K
N
V
PGV
G
AFF
A
G
EN
G
N
S
T
T
G
D
A
I
Y
M
-
RG
AD
TSNS
I
--
-
-
YIDGI
RD
-------
I
GS
----
V
SR
D
TFNT
E
Q
VEVI
K
GP
S
G
TD
YG
R
SAP
T
G
S
INM
I
SK
Q
P
R
N
DSG
I
-
D
A
SA
SI
GS
AWFR
R
GTL
D
VNQV
I
G
D
TT
AV
R
L
N
V
M
G
-E
K
T
H
DA
GR
D
KIKN
ERY
GV
AP
SVA
F
G
LG
TANR
L
YLN
----------
Y
L
HVT
QH
NTP
D
GGI
PT
I
G
LP
G
YS
A
P
SA
GT
AALN
--
H
SGK
V
D
THNFYGT
D
S
DY
D
D
STT
D
TAT
MR
--------
FEH
D
I
ND
N
T
T
I
R
N
T
T
RWS
R
VK
Q
D
Y
LM
TA
I
M
G
G
A
S
NITQ
P
TSDVN
S
W-
--------
-----------TWS
R
TANTK
D
VSN
K
I
L
TN
QT
N
L
T
S
T
F
Y
TG
S
I
G
H
D
V
S
---------------
TGV
E
F
T
R
--
-
ETQ
T
N
--------------------
Y
G
VN
---
P
VTL
P
AV
N
IYH
PD
-
--------S
S
IH
P
GGLTRNGA
N
ANG
QT
DTFA
I
YA
F
D
TL
Q
ITRD
F
E
L
N
GG
I
R
LD
N
Y
HTE
YD
S
AT
A
CGGSGRGAITCP
AGMAKGSPV
T
T
VDT
--
AKSG
N
LV
N
W
K
AG
AL
Y
H
L
T
E
NG
-
N
V
Y
I
N
YA
V
S
Q
Q
-----
P
PGGNNFALA
Q
S
GSG
---
N
S
A
N
RT
D
F
K
P
Q
K
A
N
T
S
EIG
T
K
WQVL
D
K
RL
LL
T
A
ALFR
TDIE
N
EVE
--------
Q
N
D
D
GTY
SQ
Y
--
G
KK
R
V
E
G
Y
EI
S
VA
---
G
N
IT
P
AWQV
I
GGYT
QQK
A
-
----
T
IK
NG
K
DV
AQ
DGSSSLPY
T
PEH
AFT
LWS
Q
Y
QAT
D
-
-
--
D
IS
VG
A
G
A
RY
I
G
---
S
MHKGS
D
-
G
A
V
GT
PA
F
TE
G
-
Y
W
V
A
DA
KL
G
Y
R
V
N
R
----
N
L
D
F
QLNV
Y
NLFD
TD
YVAS
INK
S
G
Y
-------
RYHP
G
E
PR
T
F
LL
TA
N
MH
F
fig|679206.4.peg.4022
Escherichia coli MS 119-7 (5-760/760)
RNFPARQFHSL
----
TF
F
AG
LCI
G
ITPV
AQA
L
AAE
GQT
NAD
DTL
V
VEAS
T
PSL
Y
APQQSA
----
----------
DP
K
FSR
P
VA
D
T
TRT
MTV
I
S
E
Q
V
I
K
DQ
G
AT
NL
T
D
AL
K
N
V
PGV
G
AFF
A
G
EN
G
N
S
T
T
G
D
A
I
Y
M
-
RG
AD
TSNS
I
--
-
-
YIDGI
RD
-------
I
GS
----
V
SR
D
TFNT
E
Q
VEVI
K
GP
S
G
TD
YG
R
SAP
T
G
S
INM
I
SK
Q
P
R
N
DSG
I
-
D
A
SA
SI
GS
AWFR
R
GTL
D
VNQV
I
G
D
TT
AV
R
L
N
V
M
G
-E
K
T
H
DA
GR
D
KVKN
ERY
GV
AP
SIA
F
G
LG
TANR
L
YLN
----------
Y
L
HVT
QH
NTP
D
GGI
PT
I
G
LP
G
YS
A
P
SA
GT
AALN
--
H
SGK
V
D
THNFYGT
D
S
DY
D
D
STT
D
TAT
MR
--------
FEH
D
I
ND
N
T
T
I
R
N
T
T
RWS
R
VK
Q
D
Y
LM
TA
I
M
G
G
A
S
NITQ
P
TSDVN
S
W-
--------
-----------TWS
R
TANTK
D
VSN
K
I
L
TN
QT
N
L
T
S
T
F
Y
TG
S
I
G
H
D
V
T
---------------
TGV
E
F
T
R
--
-
ETQ
T
N
--------------------
Y
G
VN
---
P
VTL
P
AV
N
IYH
PD
-
--------S
S
IH
P
GGLTRNGA
N
ANG
QT
DTFA
I
YA
F
D
TL
Q
ITRD
F
E
L
N
GG
I
R
LD
N
Y
HTE
YD
S
AT
A
CGGSGRGAITCP
TGVAKGSPV
T
T
VDT
--
AKSG
N
LV
N
W
K
AG
AL
Y
H
L
T
E
NG
-
N
V
Y
I
N
YA
V
S
Q
Q
-----
P
PGGNNFALA
Q
S
GSG
---
N
S
A
N
RT
D
F
K
P
Q
K
A
N
T
S
EIG
T
K
WQVL
D
K
RL
LL
T
A
ALFR
TDIE
N
EVE
--------
Q
N
D
D
GTY
SQ
Y
--
G
KK
R
V
E
G
Y
EI
S
VA
---
G
N
IT
P
AWQV
I
GGYT
QQK
A
-
----
T
IK
NG
K
DV
AQ
DGSSSLPY
T
PEH
AFT
LWS
Q
Y
QAT
D
-
-
--
D
IS
VG
A
G
A
RY
I
G
---
S
MHKGS
D
-
G
A
V
GT
PA
F
TE
G
-
Y
W
V
A
DA
KL
G
Y
R
V
N
R
----
N
L
D
F
QLNV
Y
NLFD
TD
YVAS
INK
S
G
Y
-------
RYHP
G
E
PR
T
F
LL
TA
N
MH
F
fig|525281.3.peg.2148
Escherichia coli 83972 (5-760/760)
RNFPARQFHSL
----
TF
F
AG
LCI
G
ITPV
AQA
L
AAE
GQA
NAD
DTL
V
VEAS
T
PSL
Y
APQQSA
----
----------
DP
K
FSR
P
VA
D
T
TRT
MTV
I
S
E
Q
V
I
K
DQ
G
AT
NL
T
D
AL
K
N
V
PGV
G
AFF
A
G
EN
G
N
S
T
T
G
D
A
I
Y
M
-
RG
AD
TSNS
I
--
-
-
YIDGI
RD
-------
I
GS
----
V
SR
D
TFNT
E
Q
VEVI
K
GP
S
G
TD
YG
R
SAP
T
G
S
INM
I
SK
Q
P
R
N
DSG
I
-
D
A
SA
SI
GS
AWFR
R
GTL
D
VNQV
I
G
D
TT
AV
R
L
N
V
M
G
-E
K
T
H
DA
GR
D
KVKN
ERY
GV
AP
SVA
F
G
LG
TANR
L
YLN
----------
Y
L
HVT
QH
NTP
D
GGI
PT
I
G
LP
G
YS
A
P
SA
GT
AALN
--
H
SGK
V
D
THNFYGT
D
S
DY
D
D
STT
D
TAT
MR
--------
FEH
D
I
ND
N
T
T
I
R
N
T
T
RWS
R
VK
Q
D
Y
LM
TA
I
M
G
G
A
S
NITQ
P
TSDVN
S
W-
--------
-----------TWS
R
TANTK
D
VSN
K
I
L
TN
QT
N
L
T
S
T
F
Y
TG
A
I
G
H
D
L
S
---------------
TGV
E
F
T
R
--
-
ETQ
T
N
--------------------
Y
G
VN
---
P
VTL
P
AV
N
IYH
PD
-
--------S
S
IH
P
GGLTRNGA
N
ANG
QT
DTFA
I
YA
F
D
TL
Q
ITRD
F
E
L
N
GG
I
R
LD
N
Y
HTE
YD
S
AT
A
CGGSGRGAITCP
AGVAKGSPV
T
T
VDT
--
AKSG
N
LV
N
W
K
AG
AL
Y
H
L
T
E
NG
-
N
V
Y
I
N
YA
V
S
Q
Q
-----
P
PGGNNFALA
Q
S
GSG
---
N
S
A
N
RT
D
F
K
P
Q
K
A
N
T
S
EIG
T
K
WQVL
D
K
RL
LL
T
A
ALFR
TDIE
N
EVE
--------
Q
N
D
D
GTY
SQ
Y
--
G
KK
R
V
E
G
Y
EI
S
VA
---
G
N
IT
P
AWQ
M
I
GGYT
QQK
A
-
----
T
IK
NG
K
DV
AQ
DGSSSLPY
T
PEH
AFT
LWS
Q
Y
QAT
D
-
-
--
D
IS
VG
A
G
A
RY
I
G
---
S
MHKGS
D
-
G
A
V
GT
PA
F
TE
G
-
Y
W
V
A
DA
KL
G
Y
R
V
N
R
----
N
L
D
F
QLNV
Y
NLFD
TD
YVAS
INK
S
G
Y
-------
RYHP
G
E
PR
T
F
LL
TA
N
MH
F
fig|655817.3.peg.890
Escherichia coli ABU 83972 (5-760/760)
RNFPARQFHSL
----
TF
F
AG
LCI
G
ITPV
AQA
L
AAE
GQA
NAD
DTL
V
VEAS
T
PSL
Y
APQQSA
----
----------
DP
K
FSR
P
VA
D
T
TRT
MTV
I
S
E
Q
V
I
K
DQ
G
AT
NL
T
D
AL
K
N
V
PGV
G
AFF
A
G
EN
G
N
S
T
T
G
D
A
I
Y
M
-
RG
AD
TSNS
I
--
-
-
YIDGI
RD
-------
I
GS
----
V
SR
D
TFNT
E
Q
VEVI
K
GP
S
G
TD
YG
R
SAP
T
G
S
INM
I
SK
Q
P
R
N
DSG
I
-
D
A
SA
SI
GS
AWFR
R
GTL
D
VNQV
I
G
D
TT
AV
R
L
N
V
M
G
-E
K
T
H
DA
GR
D
KVKN
ERY
GV
AP
SVA
F
G
LG
TANR
L
YLN
----------
Y
L
HVT
QH
NTP
D
GGI
PT
I
G
LP
G
YS
A
P
SA
GT
AALN
--
H
SGK
V
D
THNFYGT
D
S
DY
D
D
STT
D
TAT
MR
--------
FEH
D
I
ND
N
T
T
I
R
N
T
T
RWS
R
VK
Q
D
Y
LM
TA
I
M
G
G
A
S
NITQ
P
TSDVN
S
W-
--------
-----------TWS
R
TANTK
D
VSN
K
I
L
TN
QT
N
L
T
S
T
F
Y
TG
A
I
G
H
D
L
S
---------------
TGV
E
F
T
R
--
-
ETQ
T
N
--------------------
Y
G
VN
---
P
VTL
P
AV
N
IYH
PD
-
--------S
S
IH
P
GGLTRNGA
N
ANG
QT
DTFA
I
YA
F
D
TL
Q
ITRD
F
E
L
N
GG
I
R
LD
N
Y
HTE
YD
S
AT
A
CGGSGRGAITCP
AGVAKGSPV
T
T
VDT
--
AKSG
N
LV
N
W
K
AG
AL
Y
H
L
T
E
NG
-
N
V
Y
I
N
YA
V
S
Q
Q
-----
P
PGGNNFALA
Q
S
GSG
---
N
S
A
N
RT
D
F
K
P
Q
K
A
N
T
S
EIG
T
K
WQVL
D
K
RL
LL
T
A
ALFR
TDIE
N
EVE
--------
Q
N
D
D
GTY
SQ
Y
--
G
KK
R
V
E
G
Y
EI
S
VA
---
G
N
IT
P
AWQ
M
I
GGYT
QQK
A
-
----
T
IK
NG
K
DV
AQ
DGSSSLPY
T
PEH
AFT
LWS
Q
Y
QAT
D
-
-
--
D
IS
VG
A
G
A
RY
I
G
---
S
MHKGS
D
-
G
A
V
GT
PA
F
TE
G
-
Y
W
V
A
DA
KL
G
Y
R
V
N
R
----
N
L
D
F
QLNV
Y
NLFD
TD
YVAS
INK
S
G
Y
-------
RYHP
G
E
PR
T
F
LL
TA
N
MH
F
fig|749546.3.peg.4958
Escherichia coli MS 185-1 (5-760/760)
RNFPARQFHSL
----
TF
F
AG
LCI
G
ITPV
AQA
L
AAE
GQA
NAD
DTL
V
VEAS
T
PSL
Y
APQQSA
----
----------
DP
K
FSR
P
VA
D
T
TRT
MTV
I
S
E
Q
V
I
K
DQ
G
AT
NL
T
D
AL
K
N
V
PGV
G
AFF
A
G
EN
G
N
S
T
T
G
D
A
I
Y
M
-
RG
AD
TSNS
I
--
-
-
YIDGI
RD
-------
I
GS
----
V
SR
D
TFNT
E
Q
VEVI
K
GP
S
G
TD
YG
R
SAP
T
G
S
INM
I
SK
Q
P
R
N
DSG
I
-
D
A
SA
SI
GS
AWFR
R
GTL
D
VNQV
I
G
D
TT
AV
R
L
N
V
M
G
-E
K
T
H
DA
GR
D
KVKN
ERY
GV
AP
SVA
F
G
LG
TANR
L
YLN
----------
Y
L
HVT
QH
NTP
D
GGI
PT
I
G
LP
G
YS
A
P
SA
GT
AALN
--
H
SGK
V
D
THNFYGT
D
S
DY
D
D
STT
D
TAT
MR
--------
FEH
D
I
ND
N
T
T
I
R
N
T
T
RWS
R
VK
Q
D
Y
LM
TA
I
M
G
G
A
S
NITQ
P
TSDVN
S
W-
--------
-----------TWS
R
TANTK
D
VSN
K
I
L
TN
QT
N
L
T
S
T
F
Y
TG
A
I
G
H
D
L
S
---------------
TGV
E
F
T
R
--
-
ETQ
T
N
--------------------
Y
G
VN
---
P
VTL
P
AV
N
IYH
PD
-
--------S
S
IH
P
GGLTRNGA
N
ANG
QT
DTFA
I
YA
F
D
TL
Q
ITRD
F
E
L
N
GG
I
R
LD
N
Y
HTE
YD
S
AT
A
CGGSGRGAITCP
AGVAKGSPV
T
T
VDT
--
AKSG
N
LV
N
W
K
AG
AL
Y
H
L
T
E
NG
-
N
V
Y
I
N
YA
V
S
Q
Q
-----
P
PGGNNFALA
Q
S
GSG
---
N
S
A
N
RT
D
F
K
P
Q
K
A
N
T
S
EIG
T
K
WQVL
D
K
RL
LL
T
A
ALFR
TDIE
N
EVE
--------
Q
N
D
D
GTY
SQ
Y
--
G
KK
R
V
E
G
Y
EI
S
VA
---
G
N
IT
P
AWQ
M
I
GGYT
QQK
A
-
----
T
IK
NG
K
DV
AQ
DGSSSLPY
T
PEH
AFT
LWS
Q
Y
QAT
D
-
-
--
D
IS
VG
A
G
A
RY
I
G
---
S
MHKGS
D
-
G
A
V
GT
PA
F
TE
G
-
Y
W
V
A
DA
KL
G
Y
R
V
N
R
----
N
L
D
F
QLNV
Y
NLFD
TD
YVAS
INK
S
G
Y
-------
RYHP
G
E
PR
T
F
LL
TA
N
MH
F
fig|749528.3.peg.4543
Escherichia coli MS 45-1 (5-760/760)
RNFPARQFHSL
----
TF
F
AG
LCI
G
ITPV
AQA
L
AAE
GQA
NAD
DTL
V
VEAS
T
PSL
Y
APQQSA
----
----------
DP
K
FSR
P
VA
D
T
TRT
MTV
I
S
E
Q
V
I
K
DQ
G
AT
NL
T
D
AL
K
N
V
PGV
G
AFF
A
G
EN
G
N
S
T
T
G
D
A
I
Y
M
-
RG
AD
TSNS
I
--
-
-
YIDGI
RD
-------
I
GS
----
V
SR
D
TFNT
E
Q
VEVI
K
GP
S
G
TD
YG
R
SAP
T
G
S
INM
I
SK
Q
P
R
N
DSG
I
-
D
A
SA
SI
GS
AWFR
R
GTL
D
VNQV
I
G
D
TT
AV
R
L
N
V
M
G
-E
K
T
H
DA
GR
D
KVKN
ERY
GV
AP
SVA
F
G
LG
TANR
L
YLN
----------
Y
L
HVT
QH
NTP
D
GGI
PT
I
G
LP
G
YS
A
P
SA
GT
AALN
--
H
SGK
V
D
THNFYGT
D
S
DY
D
D
STT
D
TAT
MR
--------
FEH
D
I
ND
N
T
T
I
R
N
T
T
RWS
R
VK
Q
D
Y
LM
TA
I
M
G
G
A
S
NITQ
P
TSDVN
S
W-
--------
-----------TWS
R
TANTK
D
VSN
K
I
L
TN
QT
N
L
T
S
T
F
Y
TG
A
I
G
H
D
L
S
---------------
TGV
E
F
T
R
--
-
ETQ
T
N
--------------------
Y
G
VN
---
P
VTL
P
AV
N
IYH
PD
-
--------S
S
IH
P
GGLTRNGA
N
ANG
QT
DTFA
I
YA
F
D
TL
Q
ITRD
F
E
L
N
GG
I
R
LD
N
Y
HTE
YD
S
AT
A
CGGSGRGAITCP
AGVAKGSPV
T
T
VDT
--
AKSG
N
LV
N
W
K
AG
AL
Y
H
L
T
E
NG
-
N
V
Y
I
N
YA
V
S
Q
Q
-----
P
PGGNNFALA
Q
S
GSG
---
N
S
A
N
RT
D
F
K
P
Q
K
A
N
T
S
EIG
T
K
WQVL
D
K
RL
LL
T
A
ALFR
TDIE
N
EVE
--------
Q
N
D
D
GTY
SQ
Y
--
G
KK
R
V
E
G
Y
EI
S
VA
---
G
N
IT
P
AWQ
M
I
GGYT
QQK
A
-
----
T
IK
NG
K
DV
AQ
DGSSSLPY
T
PEH
AFT
LWS
Q
Y
QAT
D
-
-
--
D
IS
VG
A
G
A
RY
I
G
---
S
MHKGS
D
-
G
A
V
GT
PA
F
TE
G
-
Y
W
V
A
DA
KL
G
Y
R
V
N
R
----
N
L
D
F
QLNV
Y
NLFD
TD
YVAS
INK
S
G
Y
-------
RYHP
G
E
PR
T
F
LL
TA
N
MH
F
fig|670888.3.peg.1366
Escherichia coli 1827-70 (5-760/760)
RNFPARQFHSL
----
TF
F
AG
LCI
G
ITPV
AQA
L
AAE
GQT
NAD
DTL
V
VEAS
T
PSL
Y
APQQSA
----
----------
DP
K
FSR
P
VA
D
T
TRT
MTV
I
S
E
Q
V
I
K
DQ
G
AT
NL
T
D
AL
K
N
V
PGV
G
AFF
A
G
EN
G
N
S
T
T
G
D
A
I
Y
M
-
RG
AD
TSNS
I
--
-
-
YIDGI
RD
-------
I
GS
----
V
SR
D
TFNT
E
Q
VEVI
K
GP
S
G
TD
YG
R
SAP
T
G
S
INM
I
SK
Q
P
R
N
DSG
I
-
D
A
SA
SI
GS
AWFR
R
GTL
D
VNQV
I
G
D
TT
AV
R
L
N
V
M
G
-E
K
T
H
DA
GR
D
KVKN
ERY
GV
AP
SVA
F
G
LG
TANR
L
YLN
----------
Y
L
HVT
QH
NTP
D
GGI
PT
I
G
LP
G
YS
A
P
SA
GT
AALN
--
H
SGK
V
D
THNFYGT
D
S
DY
D
D
STT
D
TAT
MR
--------
FEH
D
I
ND
N
T
T
I
R
N
T
T
RWS
R
VK
Q
D
Y
LM
TA
I
M
G
G
A
S
NITQ
P
TSDVN
S
W-
--------
-----------TWS
R
TANTK
D
VSN
K
I
L
TN
QT
N
L
T
S
T
F
Y
TG
S
I
G
H
D
V
S
---------------
TGV
E
F
T
R
--
-
ETQ
T
N
--------------------
Y
G
VN
---
P
VTL
P
AV
N
IYH
PD
-
--------S
S
IH
P
GGLTRNGA
N
ANG
QT
DTFA
I
YA
F
D
TL
Q
ITRD
F
E
L
N
GG
I
R
LD
N
Y
HTE
YD
S
AT
A
CGGSGRGAITCP
TGVAKGSPV
T
T
VDT
--
AKSG
N
LM
N
W
K
AG
AL
Y
H
L
T
E
NG
-
N
V
Y
I
N
YA
V
S
Q
Q
-----
P
PGGNNFALA
Q
S
GSG
---
N
S
A
N
RT
D
F
K
P
Q
K
A
N
T
S
EIG
T
K
WQVL
D
K
RL
LL
T
A
ALFR
TDIE
N
EVE
--------
Q
N
D
D
GTY
SQ
Y
--
G
KK
R
V
E
G
Y
EI
S
VA
---
G
N
IT
P
AWQV
I
GGYT
QQK
A
-
----
T
IK
NG
K
DV
AQ
DGSSSLPY
T
PEH
AFT
LWS
Q
Y
QAT
D
-
-
--
D
IS
VG
A
G
A
RY
I
G
---
S
MHKGS
D
-
G
A
V
GT
PA
F
TE
G
-
Y
W
V
A
DA
KL
G
Y
R
V
N
R
----
N
L
D
F
QLNV
Y
NLFD
TD
YVAS
INK
S
G
Y
-------
RYHP
G
E
PR
T
F
LL
TA
N
MH
F
fig|481805.3.peg.3050
Escherichia coli ATCC 8739 (5-760/760)
RNFPARQFHSL
----
TF
F
AG
LCI
G
ITPV
AQA
L
AAE
GQT
NAD
DTL
V
VEAS
T
PSL
Y
APQQSA
----
----------
DP
K
FSR
P
VA
D
T
TRT
MTV
I
S
E
Q
V
I
K
DQ
G
AT
NL
T
D
AL
K
N
V
PGV
G
AFF
A
G
EN
G
N
S
T
T
G
D
A
I
Y
M
-
RG
AD
TSNS
I
--
-
-
YIDGI
RD
-------
I
GS
----
V
SR
D
TFNT
E
Q
VEVI
K
GP
S
G
TD
YG
R
SAP
T
G
S
INM
I
SK
Q
P
R
N
DSG
I
-
D
A
SA
SI
GS
AWFR
R
GTL
D
VNQV
I
G
D
TT
AV
R
L
N
V
M
G
-E
K
T
H
DA
GR
D
KVKN
ERY
GV
AP
SVA
F
G
LG
TANR
L
YLN
----------
Y
L
HVT
QH
NTP
D
GGI
PT
I
G
LP
G
YS
A
P
SA
GT
AALN
--
H
SGK
V
D
THNFYGT
D
S
DY
D
D
STT
D
TAT
MR
--------
FEH
D
I
ND
N
T
T
I
R
N
T
T
RWS
R
VK
Q
D
Y
LM
TA
I
M
G
G
A
S
NITQ
P
TSDVN
S
W-
--------
-----------TWS
R
TANTK
D
VSN
K
I
L
TN
QT
N
L
T
S
T
F
Y
TG
S
I
G
H
D
V
S
---------------
TGV
E
F
T
R
--
-
ETQ
T
N
--------------------
Y
G
VN
---
P
VTL
P
AV
N
IYH
PD
-
--------S
S
IH
P
GGLTRNGA
N
ANG
QT
DTFA
I
YA
F
D
TL
Q
ITRD
F
E
L
N
GG
I
R
LD
N
Y
HTE
YD
S
AT
A
CGGSGRGAITCP
TGVAKGSPV
T
T
VDT
--
AKSG
N
LM
N
W
K
AG
AL
Y
H
L
T
E
NG
-
N
V
Y
I
N
YA
V
S
Q
Q
-----
P
PGGNNFALA
Q
S
GSG
---
N
S
A
N
RT
D
F
K
P
Q
K
A
N
T
S
EIG
T
K
WQVL
D
K
RL
LL
T
A
ALFR
TDIE
N
EVE
--------
Q
N
D
D
GTY
SQ
Y
--
G
KK
R
V
E
G
Y
EI
S
VA
---
G
N
IT
P
AWQV
I
GGYT
QQK
A
-
----
T
IK
NG
K
DV
AQ
DGSSSLPY
T
PEH
AFT
LWS
Q
Y
QAT
D
-
-
--
D
IS
VG
A
G
A
RY
I
G
---
S
MHKGS
D
-
G
A
V
GT
PA
F
TE
G
-
Y
W
V
A
DA
KL
G
Y
R
V
N
R
----
N
L
D
F
QLNV
Y
NLFD
TD
YVAS
INK
S
G
Y
-------
RYHP
G
E
PR
T
F
LL
TA
N
MH
F
fig|481805.6.peg.3036
Escherichia coli ATCC 8739 (5-760/760)
RNFPARQFHSL
----
TF
F
AG
LCI
G
ITPV
AQA
L
AAE
GQT
NAD
DTL
V
VEAS
T
PSL
Y
APQQSA
----
----------
DP
K
FSR
P
VA
D
T
TRT
MTV
I
S
E
Q
V
I
K
DQ
G
AT
NL
T
D
AL
K
N
V
PGV
G
AFF
A
G
EN
G
N
S
T
T
G
D
A
I
Y
M
-
RG
AD
TSNS
I
--
-
-
YIDGI
RD
-------
I
GS
----
V
SR
D
TFNT
E
Q
VEVI
K
GP
S
G
TD
YG
R
SAP
T
G
S
INM
I
SK
Q
P
R
N
DSG
I
-
D
A
SA
SI
GS
AWFR
R
GTL
D
VNQV
I
G
D
TT
AV
R
L
N
V
M
G
-E
K
T
H
DA
GR
D
KVKN
ERY
GV
AP
SVA
F
G
LG
TANR
L
YLN
----------
Y
L
HVT
QH
NTP
D
GGI
PT
I
G
LP
G
YS
A
P
SA
GT
AALN
--
H
SGK
V
D
THNFYGT
D
S
DY
D
D
STT
D
TAT
MR
--------
FEH
D
I
ND
N
T
T
I
R
N
T
T
RWS
R
VK
Q
D
Y
LM
TA
I
M
G
G
A
S
NITQ
P
TSDVN
S
W-
--------
-----------TWS
R
TANTK
D
VSN
K
I
L
TN
QT
N
L
T
S
T
F
Y
TG
S
I
G
H
D
V
S
---------------
TGV
E
F
T
R
--
-
ETQ
T
N
--------------------
Y
G
VN
---
P
VTL
P
AV
N
IYH
PD
-
--------S
S
IH
P
GGLTRNGA
N
ANG
QT
DTFA
I
YA
F
D
TL
Q
ITRD
F
E
L
N
GG
I
R
LD
N
Y
HTE
YD
S
AT
A
CGGSGRGAITCP
TGVAKGSPV
T
T
VDT
--
AKSG
N
LM
N
W
K
AG
AL
Y
H
L
T
E
NG
-
N
V
Y
I
N
YA
V
S
Q
Q
-----
P
PGGNNFALA
Q
S
GSG
---
N
S
A
N
RT
D
F
K
P
Q
K
A
N
T
S
EIG
T
K
WQVL
D
K
RL
LL
T
A
ALFR
TDIE
N
EVE
--------
Q
N
D
D
GTY
SQ
Y
--
G
KK
R
V
E
G
Y
EI
S
VA
---
G
N
IT
P
AWQV
I
GGYT
QQK
A
-
----
T
IK
NG
K
DV
AQ
DGSSSLPY
T
PEH
AFT
LWS
Q
Y
QAT
D
-
-
--
D
IS
VG
A
G
A
RY
I
G
---
S
MHKGS
D
-
G
A
V
GT
PA
F
TE
G
-
Y
W
V
A
DA
KL
G
Y
R
V
N
R
----
N
L
D
F
QLNV
Y
NLFD
TD
YVAS
INK
S
G
Y
-------
RYHP
G
E
PR
T
F
LL
TA
N
MH
F
fig|595496.3.peg.728
Escherichia coli BW2952 (5-760/760)
RNFPARQFHSL
----
TF
F
AG
LCI
G
ITPV
AQA
L
AAE
GQT
NAD
DTL
V
VEAS
T
PSL
Y
APQQSA
----
----------
DP
K
FSR
P
VA
D
T
TRT
MTV
I
S
E
Q
V
I
K
DQ
G
AT
NL
T
D
AL
K
N
V
PGV
G
AFF
A
G
EN
G
N
S
T
T
G
D
A
I
Y
M
-
RG
AD
TSNS
I
--
-
-
YIDGI
RD
-------
I
GS
----
V
SR
D
TFNT
E
Q
VEVI
K
GP
S
G
TD
YG
R
SAP
T
G
S
INM
I
SK
Q
P
R
N
DSG
I
-
D
A
SA
SI
GS
AWFR
R
GTL
D
VNQV
I
G
D
TT
AV
R
L
N
V
M
G
-E
K
T
H
DA
GR
D
KVKN
ERY
GV
AP
SVA
F
G
LG
TANR
L
YLN
----------
Y
L
HVT
QH
NTP
D
GGI
PT
I
G
LP
G
YS
A
P
SA
GT
AALN
--
H
SGK
V
D
THNFYGT
D
S
DY
D
D
STT
D
TAT
MR
--------
FEH
D
I
ND
N
T
T
I
R
N
T
T
RWS
R
VK
Q
D
Y
LM
TA
I
M
G
G
A
S
NITQ
P
TSDVN
S
W-
--------
-----------TWS
R
TANTK
D
VSN
K
I
L
TN
QT
N
L
T
S
T
F
Y
TG
S
I
G
H
D
V
S
---------------
TGV
E
F
T
R
--
-
ETQ
T
N
--------------------
Y
G
VN
---
P
VTL
P
AV
N
IYH
PD
-
--------S
S
IH
P
GGLTRNGA
N
ANG
QT
DTFA
I
YA
F
D
TL
Q
ITRD
F
E
L
N
GG
I
R
LD
N
Y
HTE
YD
S
AT
A
CGGSGRGAITCP
TGVAKGSPV
T
T
VDT
--
AKSG
N
LM
N
W
K
AG
AL
Y
H
L
T
E
NG
-
N
V
Y
I
N
YA
V
S
Q
Q
-----
P
PGGNNFALA
Q
S
GSG
---
N
S
A
N
RT
D
F
K
P
Q
K
A
N
T
S
EIG
T
K
WQVL
D
K
RL
LL
T
A
ALFR
TDIE
N
EVE
--------
Q
N
D
D
GTY
SQ
Y
--
G
KK
R
V
E
G
Y
EI
S
VA
---
G
N
IT
P
AWQV
I
GGYT
QQK
A
-
----
T
IK
NG
K
DV
AQ
DGSSSLPY
T
PEH
AFT
LWS
Q
Y
QAT
D
-
-
--
D
IS
VG
A
G
A
RY
I
G
---
S
MHKGS
D
-
G
A
V
GT
PA
F
TE
G
-
Y
W
V
A
DA
KL
G
Y
R
V
N
R
----
N
L
D
F
QLNV
Y
NLFD
TD
YVAS
INK
S
G
Y
-------
RYHP
G
E
PR
T
F
LL
TA
N
MH
F
fig|536056.3.peg.2994
Escherichia coli DH1 (5-760/760)
RNFPARQFHSL
----
TF
F
AG
LCI
G
ITPV
AQA
L
AAE
GQT
NAD
DTL
V
VEAS
T
PSL
Y
APQQSA
----
----------
DP
K
FSR
P
VA
D
T
TRT
MTV
I
S
E
Q
V
I
K
DQ
G
AT
NL
T
D
AL
K
N
V
PGV
G
AFF
A
G
EN
G
N
S
T
T
G
D
A
I
Y
M
-
RG
AD
TSNS
I
--
-
-
YIDGI
RD
-------
I
GS
----
V
SR
D
TFNT
E
Q
VEVI
K
GP
S
G
TD
YG
R
SAP
T
G
S
INM
I
SK
Q
P
R
N
DSG
I
-
D
A
SA
SI
GS
AWFR
R
GTL
D
VNQV
I
G
D
TT
AV
R
L
N
V
M
G
-E
K
T
H
DA
GR
D
KVKN
ERY
GV
AP
SVA
F
G
LG
TANR
L
YLN
----------
Y
L
HVT
QH
NTP
D
GGI
PT
I
G
LP
G
YS
A
P
SA
GT
AALN
--
H
SGK
V
D
THNFYGT
D
S
DY
D
D
STT
D
TAT
MR
--------
FEH
D
I
ND
N
T
T
I
R
N
T
T
RWS
R
VK
Q
D
Y
LM
TA
I
M
G
G
A
S
NITQ
P
TSDVN
S
W-
--------
-----------TWS
R
TANTK
D
VSN
K
I
L
TN
QT
N
L
T
S
T
F
Y
TG
S
I
G
H
D
V
S
---------------
TGV
E
F
T
R
--
-
ETQ
T
N
--------------------
Y
G
VN
---
P
VTL
P
AV
N
IYH
PD
-
--------S
S
IH
P
GGLTRNGA
N
ANG
QT
DTFA
I
YA
F
D
TL
Q
ITRD
F
E
L
N
GG
I
R
LD
N
Y
HTE
YD
S
AT
A
CGGSGRGAITCP
TGVAKGSPV
T
T
VDT
--
AKSG
N
LM
N
W
K
AG
AL
Y
H
L
T
E
NG
-
N
V
Y
I
N
YA
V
S
Q
Q
-----
P
PGGNNFALA
Q
S
GSG
---
N
S
A
N
RT
D
F
K
P
Q
K
A
N
T
S
EIG
T
K
WQVL
D
K
RL
LL
T
A
ALFR
TDIE
N
EVE
--------
Q
N
D
D
GTY
SQ
Y
--
G
KK
R
V
E
G
Y
EI
S
VA
---
G
N
IT
P
AWQV
I
GGYT
QQK
A
-
----
T
IK
NG
K
DV
AQ
DGSSSLPY
T
PEH
AFT
LWS
Q
Y
QAT
D
-
-
--
D
IS
VG
A
G
A
RY
I
G
---
S
MHKGS
D
-
G
A
V
GT
PA
F
TE
G
-
Y
W
V
A
DA
KL
G
Y
R
V
N
R
----
N
L
D
F
QLNV
Y
NLFD
TD
YVAS
INK
S
G
Y
-------
RYHP
G
E
PR
T
F
LL
TA
N
MH
F
fig|562.375.peg.4396
Escherichia coli EC4100B (5-760/760)
RNFPARQFHSL
----
TF
F
AG
LCI
G
ITPV
AQA
L
AAE
GQT
NAD
DTL
V
VEAS
T
PSL
Y
APQQSA
----
----------
DP
K
FSR
P
VA
D
T
TRT
MTV
I
S
E
Q
V
I
K
DQ
G
AT
NL
T
D
AL
K
N
V
PGV
G
AFF
A
G
EN
G
N
S
T
T
G
D
A
I
Y
M
-
RG
AD
TSNS
I
--
-
-
YIDGI
RD
-------
I
GS
----
V
SR
D
TFNT
E
Q
VEVI
K
GP
S
G
TD
YG
R
SAP
T
G
S
INM
I
SK
Q
P
R
N
DSG
I
-
D
A
SA
SI
GS
AWFR
R
GTL
D
VNQV
I
G
D
TT
AV
R
L
N
V
M
G
-E
K
T
H
DA
GR
D
KVKN
ERY
GV
AP
SVA
F
G
LG
TANR
L
YLN
----------
Y
L
HVT
QH
NTP
D
GGI
PT
I
G
LP
G
YS
A
P
SA
GT
AALN
--
H
SGK
V
D
THNFYGT
D
S
DY
D
D
STT
D
TAT
MR
--------
FEH
D
I
ND
N
T
T
I
R
N
T
T
RWS
R
VK
Q
D
Y
LM
TA
I
M
G
G
A
S
NITQ
P
TSDVN
S
W-
--------
-----------TWS
R
TANTK
D
VSN
K
I
L
TN
QT
N
L
T
S
T
F
Y
TG
S
I
G
H
D
V
S
---------------
TGV
E
F
T
R
--
-
ETQ
T
N
--------------------
Y
G
VN
---
P
VTL
P
AV
N
IYH
PD
-
--------S
S
IH
P
GGLTRNGA
N
ANG
QT
DTFA
I
YA
F
D
TL
Q
ITRD
F
E
L
N
GG
I
R
LD
N
Y
HTE
YD
S
AT
A
CGGSGRGAITCP
TGVAKGSPV
T
T
VDT
--
AKSG
N
LM
N
W
K
AG
AL
Y
H
L
T
E
NG
-
N
V
Y
I
N
YA
V
S
Q
Q
-----
P
PGGNNFALA
Q
S
GSG
---
N
S
A
N
RT
D
F
K
P
Q
K
A
N
T
S
EIG
T
K
WQVL
D
K
RL
LL
T
A
ALFR
TDIE
N
EVE
--------
Q
N
D
D
GTY
SQ
Y
--
G
KK
R
V
E
G
Y
EI
S
VA
---
G
N
IT
P
AWQV
I
GGYT
QQK
A
-
----
T
IK
NG
K
DV
AQ
DGSSSLPY
T
PEH
AFT
LWS
Q
Y
QAT
D
-
-
--
D
IS
VG
A
G
A
RY
I
G
---
S
MHKGS
D
-
G
A
V
GT
PA
F
TE
G
-
Y
W
V
A
DA
KL
G
Y
R
V
N
R
----
N
L
D
F
QLNV
Y
NLFD
TD
YVAS
INK
S
G
Y
-------
RYHP
G
E
PR
T
F
LL
TA
N
MH
F
fig|316401.4.peg.1011
Escherichia coli ETEC H10407 (5-760/760)
RNFPARQFHSL
----
TF
F
AG
LCI
G
ITPV
AQA
L
AAE
GQT
NAD
DTL
V
VEAS
T
PSL
Y
APQQSA
----
----------
DP
K
FSR
P
VA
D
T
TRT
MTV
I
S
E
Q
V
I
K
DQ
G
AT
NL
T
D
AL
K
N
V
PGV
G
AFF
A
G
EN
G
N
S
T
T
G
D
A
I
Y
M
-
RG
AD
TSNS
I
--
-
-
YIDGI
RD
-------
I
GS
----
V
SR
D
TFNT
E
Q
VEVI
K
GP
S
G
TD
YG
R
SAP
T
G
S
INM
I
SK
Q
P
R
N
DSG
I
-
D
A
SA
SI
GS
AWFR
R
GTL
D
VNQV
I
G
D
TT
AV
R
L
N
V
M
G
-E
K
T
H
DA
GR
D
KVKN
ERY
GV
AP
SVA
F
G
LG
TANR
L
YLN
----------
Y
L
HVT
QH
NTP
D
GGI
PT
I
G
LP
G
YS
A
P
SA
GT
AALN
--
H
SGK
V
D
THNFYGT
D
S
DY
D
D
STT
D
TAT
MR
--------
FEH
D
I
ND
N
T
T
I
R
N
T
T
RWS
R
VK
Q
D
Y
LM
TA
I
M
G
G
A
S
NITQ
P
TSDVN
S
W-
--------
-----------TWS
R
TANTK
D
VSN
K
I
L
TN
QT
N
L
T
S
T
F
Y
TG
S
I
G
H
D
V
S
---------------
TGV
E
F
T
R
--
-
ETQ
T
N
--------------------
Y
G
VN
---
P
VTL
P
AV
N
IYH
PD
-
--------S
S
IH
P
GGLTRNGA
N
ANG
QT
DTFA
I
YA
F
D
TL
Q
ITRD
F
E
L
N
GG
I
R
LD
N
Y
HTE
YD
S
AT
A
CGGSGRGAITCP
TGVAKGSPV
T
T
VDT
--
AKSG
N
LM
N
W
K
AG
AL
Y
H
L
T
E
NG
-
N
V
Y
I
N
YA
V
S
Q
Q
-----
P
PGGNNFALA
Q
S
GSG
---
N
S
A
N
RT
D
F
K
P
Q
K
A
N
T
S
EIG
T
K
WQVL
D
K
RL
LL
T
A
ALFR
TDIE
N
EVE
--------
Q
N
D
D
GTY
SQ
Y
--
G
KK
R
V
E
G
Y
EI
S
VA
---
G
N
IT
P
AWQV
I
GGYT
QQK
A
-
----
T
IK
NG
K
DV
AQ
DGSSSLPY
T
PEH
AFT
LWS
Q
Y
QAT
D
-
-
--
D
IS
VG
A
G
A
RY
I
G
---
S
MHKGS
D
-
G
A
V
GT
PA
F
TE
G
-
Y
W
V
A
DA
KL
G
Y
R
V
N
R
----
N
L
D
F
QLNV
Y
NLFD
TD
YVAS
INK
S
G
Y
-------
RYHP
G
E
PR
T
F
LL
TA
N
MH
F
fig|656414.3.peg.1004
Escherichia coli H736 (5-760/760)
RNFPARQFHSL
----
TF
F
AG
LCI
G
ITPV
AQA
L
AAE
GQT
NAD
DTL
V
VEAS
T
PSL
Y
APQQSA
----
----------
DP
K
FSR
P
VA
D
T
TRT
MTV
I
S
E
Q
V
I
K
DQ
G
AT
NL
T
D
AL
K
N
V
PGV
G
AFF
A
G
EN
G
N
S
T
T
G
D
A
I
Y
M
-
RG
AD
TSNS
I
--
-
-
YIDGI
RD
-------
I
GS
----
V
SR
D
TFNT
E
Q
VEVI
K
GP
S
G
TD
YG
R
SAP
T
G
S
INM
I
SK
Q
P
R
N
DSG
I
-
D
A
SA
SI
GS
AWFR
R
GTL
D
VNQV
I
G
D
TT
AV
R
L
N
V
M
G
-E
K
T
H
DA
GR
D
KVKN
ERY
GV
AP
SVA
F
G
LG
TANR
L
YLN
----------
Y
L
HVT
QH
NTP
D
GGI
PT
I
G
LP
G
YS
A
P
SA
GT
AALN
--
H
SGK
V
D
THNFYGT
D
S
DY
D
D
STT
D
TAT
MR
--------
FEH
D
I
ND
N
T
T
I
R
N
T
T
RWS
R
VK
Q
D
Y
LM
TA
I
M
G
G
A
S
NITQ
P
TSDVN
S
W-
--------
-----------TWS
R
TANTK
D
VSN
K
I
L
TN
QT
N
L
T
S
T
F
Y
TG
S
I
G
H
D
V
S
---------------
TGV
E
F
T
R
--
-
ETQ
T
N
--------------------
Y
G
VN
---
P
VTL
P
AV
N
IYH
PD
-
--------S
S
IH
P
GGLTRNGA
N
ANG
QT
DTFA
I
YA
F
D
TL
Q
ITRD
F
E
L
N
GG
I
R
LD
N
Y
HTE
YD
S
AT
A
CGGSGRGAITCP
TGVAKGSPV
T
T
VDT
--
AKSG
N
LM
N
W
K
AG
AL
Y
H
L
T
E
NG
-
N
V
Y
I
N
YA
V
S
Q
Q
-----
P
PGGNNFALA
Q
S
GSG
---
N
S
A
N
RT
D
F
K
P
Q
K
A
N
T
S
EIG
T
K
WQVL
D
K
RL
LL
T
A
ALFR
TDIE
N
EVE
--------
Q
N
D
D
GTY
SQ
Y
--
G
KK
R
V
E
G
Y
EI
S
VA
---
G
N
IT
P
AWQV
I
GGYT
QQK
A
-
----
T
IK
NG
K
DV
AQ
DGSSSLPY
T
PEH
AFT
LWS
Q
Y
QAT
D
-
-
--
D
IS
VG
A
G
A
RY
I
G
---
S
MHKGS
D
-
G
A
V
GT
PA
F
TE
G
-
Y
W
V
A
DA
KL
G
Y
R
V
N
R
----
N
L
D
F
QLNV
Y
NLFD
TD
YVAS
INK
S
G
Y
-------
RYHP
G
E
PR
T
F
LL
TA
N
MH
F
fig|331112.3.peg.796
Escherichia coli HS (5-760/760)
RNFPARQFHSL
----
TF
F
AG
LCI
G
ITPV
AQA
L
AAE
GQT
NAD
DTL
V
VEAS
T
PSL
Y
APQQSA
----
----------
DP
K
FSR
P
VA
D
T
TRT
MTV
I
S
E
Q
V
I
K
DQ
G
AT
NL
T
D
AL
K
N
V
PGV
G
AFF
A
G
EN
G
N
S
T
T
G
D
A
I
Y
M
-
RG
AD
TSNS
I
--
-
-
YIDGI
RD
-------
I
GS
----
V
SR
D
TFNT
E
Q
VEVI
K
GP
S
G
TD
YG
R
SAP
T
G
S
INM
I
SK
Q
P
R
N
DSG
I
-
D
A
SA
SI
GS
AWFR
R
GTL
D
VNQV
I
G
D
TT
AV
R
L
N
V
M
G
-E
K
T
H
DA
GR
D
KVKN
ERY
GV
AP
SVA
F
G
LG
TANR
L
YLN
----------
Y
L
HVT
QH
NTP
D
GGI
PT
I
G
LP
G
YS
A
P
SA
GT
AALN
--
H
SGK
V
D
THNFYGT
D
S
DY
D
D
STT
D
TAT
MR
--------
FEH
D
I
ND
N
T
T
I
R
N
T
T
RWS
R
VK
Q
D
Y
LM
TA
I
M
G
G
A
S
NITQ
P
TSDVN
S
W-
--------
-----------TWS
R
TANTK
D
VSN
K
I
L
TN
QT
N
L
T
S
T
F
Y
TG
S
I
G
H
D
V
S
---------------
TGV
E
F
T
R
--
-
ETQ
T
N
--------------------
Y
G
VN
---
P
VTL
P
AV
N
IYH
PD
-
--------S
S
IH
P
GGLTRNGA
N
ANG
QT
DTFA
I
YA
F
D
TL
Q
ITRD
F
E
L
N
GG
I
R
LD
N
Y
HTE
YD
S
AT
A
CGGSGRGAITCP
TGVAKGSPV
T
T
VDT
--
AKSG
N
LM
N
W
K
AG
AL
Y
H
L
T
E
NG
-
N
V
Y
I
N
YA
V
S
Q
Q
-----
P
PGGNNFALA
Q
S
GSG
---
N
S
A
N
RT
D
F
K
P
Q
K
A
N
T
S
EIG
T
K
WQVL
D
K
RL
LL
T
A
ALFR
TDIE
N
EVE
--------
Q
N
D
D
GTY
SQ
Y
--
G
KK
R
V
E
G
Y
EI
S
VA
---
G
N
IT
P
AWQV
I
GGYT
QQK
A
-
----
T
IK
NG
K
DV
AQ
DGSSSLPY
T
PEH
AFT
LWS
Q
Y
QAT
D
-
-
--
D
IS
VG
A
G
A
RY
I
G
---
S
MHKGS
D
-
G
A
V
GT
PA
F
TE
G
-
Y
W
V
A
DA
KL
G
Y
R
V
N
R
----
N
L
D
F
QLNV
Y
NLFD
TD
YVAS
INK
S
G
Y
-------
RYHP
G
E
PR
T
F
LL
TA
N
MH
F
fig|331112.6.peg.830
Escherichia coli HS (5-760/760)
RNFPARQFHSL
----
TF
F
AG
LCI
G
ITPV
AQA
L
AAE
GQT
NAD
DTL
V
VEAS
T
PSL
Y
APQQSA
----
----------
DP
K
FSR
P
VA
D
T
TRT
MTV
I
S
E
Q
V
I
K
DQ
G
AT
NL
T
D
AL
K
N
V
PGV
G
AFF
A
G
EN
G
N
S
T
T
G
D
A
I
Y
M
-
RG
AD
TSNS
I
--
-
-
YIDGI
RD
-------
I
GS
----
V
SR
D
TFNT
E
Q
VEVI
K
GP
S
G
TD
YG
R
SAP
T
G
S
INM
I
SK
Q
P
R
N
DSG
I
-
D
A
SA
SI
GS
AWFR
R
GTL
D
VNQV
I
G
D
TT
AV
R
L
N
V
M
G
-E
K
T
H
DA
GR
D
KVKN
ERY
GV
AP
SVA
F
G
LG
TANR
L
YLN
----------
Y
L
HVT
QH
NTP
D
GGI
PT
I
G
LP
G
YS
A
P
SA
GT
AALN
--
H
SGK
V
D
THNFYGT
D
S
DY
D
D
STT
D
TAT
MR
--------
FEH
D
I
ND
N
T
T
I
R
N
T
T
RWS
R
VK
Q
D
Y
LM
TA
I
M
G
G
A
S
NITQ
P
TSDVN
S
W-
--------
-----------TWS
R
TANTK
D
VSN
K
I
L
TN
QT
N
L
T
S
T
F
Y
TG
S
I
G
H
D
V
S
---------------
TGV
E
F
T
R
--
-
ETQ
T
N
--------------------
Y
G
VN
---
P
VTL
P
AV
N
IYH
PD
-
--------S
S
IH
P
GGLTRNGA
N
ANG
QT
DTFA
I
YA
F
D
TL
Q
ITRD
F
E
L
N
GG
I
R
LD
N
Y
HTE
YD
S
AT
A
CGGSGRGAITCP
TGVAKGSPV
T
T
VDT
--
AKSG
N
LM
N
W
K
AG
AL
Y
H
L
T
E
NG
-
N
V
Y
I
N
YA
V
S
Q
Q
-----
P
PGGNNFALA
Q
S
GSG
---
N
S
A
N
RT
D
F
K
P
Q
K
A
N
T
S
EIG
T
K
WQVL
D
K
RL
LL
T
A
ALFR
TDIE
N
EVE
--------
Q
N
D
D
GTY
SQ
Y
--
G
KK
R
V
E
G
Y
EI
S
VA
---
G
N
IT
P
AWQV
I
GGYT
QQK
A
-
----
T
IK
NG
K
DV
AQ
DGSSSLPY
T
PEH
AFT
LWS
Q
Y
QAT
D
-
-
--
D
IS
VG
A
G
A
RY
I
G
---
S
MHKGS
D
-
G
A
V
GT
PA
F
TE
G
-
Y
W
V
A
DA
KL
G
Y
R
V
N
R
----
N
L
D
F
QLNV
Y
NLFD
TD
YVAS
INK
S
G
Y
-------
RYHP
G
E
PR
T
F
LL
TA
N
MH
F
fig|83333.1.peg.791
Escherichia coli K12 (5-760/760)
RNFPARQFHSL
----
TF
F
AG
LCI
G
ITPV
AQA
L
AAE
GQT
NAD
DTL
V
VEAS
T
PSL
Y
APQQSA
----
----------
DP
K
FSR
P
VA
D
T
TRT
MTV
I
S
E
Q
V
I
K
DQ
G
AT
NL
T
D
AL
K
N
V
PGV
G
AFF
A
G
EN
G
N
S
T
T
G
D
A
I
Y
M
-
RG
AD
TSNS
I
--
-
-
YIDGI
RD
-------
I
GS
----
V
SR
D
TFNT
E
Q
VEVI
K
GP
S
G
TD
YG
R
SAP
T
G
S
INM
I
SK
Q
P
R
N
DSG
I
-
D
A
SA
SI
GS
AWFR
R
GTL
D
VNQV
I
G
D
TT
AV
R
L
N
V
M
G
-E
K
T
H
DA
GR
D
KVKN
ERY
GV
AP
SVA
F
G
LG
TANR
L
YLN
----------
Y
L
HVT
QH
NTP
D
GGI
PT
I
G
LP
G
YS
A
P
SA
GT
AALN
--
H
SGK
V
D
THNFYGT
D
S
DY
D
D
STT
D
TAT
MR
--------
FEH
D
I
ND
N
T
T
I
R
N
T
T
RWS
R
VK
Q
D
Y
LM
TA
I
M
G
G
A
S
NITQ
P
TSDVN
S
W-
--------
-----------TWS
R
TANTK
D
VSN
K
I
L
TN
QT
N
L
T
S
T
F
Y
TG
S
I
G
H
D
V
S
---------------
TGV
E
F
T
R
--
-
ETQ
T
N
--------------------
Y
G
VN
---
P
VTL
P
AV
N
IYH
PD
-
--------S
S
IH
P
GGLTRNGA
N
ANG
QT
DTFA
I
YA
F
D
TL
Q
ITRD
F
E
L
N
GG
I
R
LD
N
Y
HTE
YD
S
AT
A
CGGSGRGAITCP
TGVAKGSPV
T
T
VDT
--
AKSG
N
LM
N
W
K
AG
AL
Y
H
L
T
E
NG
-
N
V
Y
I
N
YA
V
S
Q
Q
-----
P
PGGNNFALA
Q
S
GSG
---
N
S
A
N
RT
D
F
K
P
Q
K
A
N
T
S
EIG
T
K
WQVL
D
K
RL
LL
T
A
ALFR
TDIE
N
EVE
--------
Q
N
D
D
GTY
SQ
Y
--
G
KK
R
V
E
G
Y
EI
S
VA
---
G
N
IT
P
AWQV
I
GGYT
QQK
A
-
----
T
IK
NG
K
DV
AQ
DGSSSLPY
T
PEH
AFT
LWS
Q
Y
QAT
D
-
-
--
D
IS
VG
A
G
A
RY
I
G
---
S
MHKGS
D
-
G
A
V
GT
PA
F
TE
G
-
Y
W
V
A
DA
KL
G
Y
R
V
N
R
----
N
L
D
F
QLNV
Y
NLFD
TD
YVAS
INK
S
G
Y
-------
RYHP
G
E
PR
T
F
LL
TA
N
MH
F
fig|749537.3.peg.3550
Escherichia coli MS 115-1 (5-760/760)
RNFPARQFHSL
----
TF
F
AG
LCI
G
ITPV
AQA
L
AAE
GQT
NAD
DTL
V
VEAS
T
PSL
Y
APQQSA
----
----------
DP
K
FSR
P
VA
D
T
TRT
MTV
I
S
E
Q
V
I
K
DQ
G
AT
NL
T
D
AL
K
N
V
PGV
G
AFF
A
G
EN
G
N
S
T
T
G
D
A
I
Y
M
-
RG
AD
TSNS
I
--
-
-
YIDGI
RD
-------
I
GS
----
V
SR
D
TFNT
E
Q
VEVI
K
GP
S
G
TD
YG
R
SAP
T
G
S
INM
I
SK
Q
P
R
N
DSG
I
-
D
A
SA
SI
GS
AWFR
R
GTL
D
VNQV
I
G
D
TT
AV
R
L
N
V
M
G
-E
K
T
H
DA
GR
D
KVKN
ERY
GV
AP
SVA
F
G
LG
TANR
L
YLN
----------
Y
L
HVT
QH
NTP
D
GGI
PT
I
G
LP
G
YS
A
P
SA
GT
AALN
--
H
SGK
V
D
THNFYGT
D
S
DY
D
D
STT
D
TAT
MR
--------
FEH
D
I
ND
N
T
T
I
R
N
T
T
RWS
R
VK
Q
D
Y
LM
TA
I
M
G
G
A
S
NITQ
P
TSDVN
S
W-
--------
-----------TWS
R
TANTK
D
VSN
K
I
L
TN
QT
N
L
T
S
T
F
Y
TG
S
I
G
H
D
V
S
---------------
TGV
E
F
T
R
--
-
ETQ
T
N
--------------------
Y
G
VN
---
P
VTL
P
AV
N
IYH
PD
-
--------S
S
IH
P
GGLTRNGA
N
ANG
QT
DTFA
I
YA
F
D
TL
Q
ITRD
F
E
L
N
GG
I
R
LD
N
Y
HTE
YD
S
AT
A
CGGSGRGAITCP
TGVAKGSPV
T
T
VDT
--
AKSG
N
LM
N
W
K
AG
AL
Y
H
L
T
E
NG
-
N
V
Y
I
N
YA
V
S
Q
Q
-----
P
PGGNNFALA
Q
S
GSG
---
N
S
A
N
RT
D
F
K
P
Q
K
A
N
T
S
EIG
T
K
WQVL
D
K
RL
LL
T
A
ALFR
TDIE
N
EVE
--------
Q
N
D
D
GTY
SQ
Y
--
G
KK
R
V
E
G
Y
EI
S
VA
---
G
N
IT
P
AWQV
I
GGYT
QQK
A
-
----
T
IK
NG
K
DV
AQ
DGSSSLPY
T
PEH
AFT
LWS
Q
Y
QAT
D
-
-
--
D
IS
VG
A
G
A
RY
I
G
---
S
MHKGS
D
-
G
A
V
GT
PA
F
TE
G
-
Y
W
V
A
DA
KL
G
Y
R
V
N
R
----
N
L
D
F
QLNV
Y
NLFD
TD
YVAS
INK
S
G
Y
-------
RYHP
G
E
PR
T
F
LL
TA
N
MH
F
fig|749538.3.peg.727
Escherichia coli MS 116-1 (5-760/760)
RNFPARQFHSL
----
TF
F
AG
LCI
G
ITPV
AQA
L
AAE
GQT
NAD
DTL
V
VEAS
T
PSL
Y
APQQSA
----
----------
DP
K
FSR
P
VA
D
T
TRT
MTV
I
S
E
Q
V
I
K
DQ
G
AT
NL
T
D
AL
K
N
V
PGV
G
AFF
A
G
EN
G
N
S
T
T
G
D
A
I
Y
M
-
RG
AD
TSNS
I
--
-
-
YIDGI
RD
-------
I
GS
----
V
SR
D
TFNT
E
Q
VEVI
K
GP
S
G
TD
YG
R
SAP
T
G
S
INM
I
SK
Q
P
R
N
DSG
I
-
D
A
SA
SI
GS
AWFR
R
GTL
D
VNQV
I
G
D
TT
AV
R
L
N
V
M
G
-E
K
T
H
DA
GR
D
KVKN
ERY
GV
AP
SVA
F
G
LG
TANR
L
YLN
----------
Y
L
HVT
QH
NTP
D
GGI
PT
I
G
LP
G
YS
A
P
SA
GT
AALN
--
H
SGK
V
D
THNFYGT
D
S
DY
D
D
STT
D
TAT
MR
--------
FEH
D
I
ND
N
T
T
I
R
N
T
T
RWS
R
VK
Q
D
Y
LM
TA
I
M
G
G
A
S
NITQ
P
TSDVN
S
W-
--------
-----------TWS
R
TANTK
D
VSN
K
I
L
TN
QT
N
L
T
S
T
F
Y
TG
S
I
G
H
D
V
S
---------------
TGV
E
F
T
R
--
-
ETQ
T
N
--------------------
Y
G
VN
---
P
VTL
P
AV
N
IYH
PD
-
--------S
S
IH
P
GGLTRNGA
N
ANG
QT
DTFA
I
YA
F
D
TL
Q
ITRD
F
E
L
N
GG
I
R
LD
N
Y
HTE
YD
S
AT
A
CGGSGRGAITCP
TGVAKGSPV
T
T
VDT
--
AKSG
N
LM
N
W
K
AG
AL
Y
H
L
T
E
NG
-
N
V
Y
I
N
YA
V
S
Q
Q
-----
P
PGGNNFALA
Q
S
GSG
---
N
S
A
N
RT
D
F
K
P
Q
K
A
N
T
S
EIG
T
K
WQVL
D
K
RL
LL
T
A
ALFR
TDIE
N
EVE
--------
Q
N
D
D
GTY
SQ
Y
--
G
KK
R
V
E
G
Y
EI
S
VA
---
G
N
IT
P
AWQV
I
GGYT
QQK
A
-
----
T
IK
NG
K
DV
AQ
DGSSSLPY
T
PEH
AFT
LWS
Q
Y
QAT
D
-
-
--
D
IS
VG
A
G
A
RY
I
G
---
S
MHKGS
D
-
G
A
V
GT
PA
F
TE
G
-
Y
W
V
A
DA
KL
G
Y
R
V
N
R
----
N
L
D
F
QLNV
Y
NLFD
TD
YVAS
INK
S
G
Y
-------
RYHP
G
E
PR
T
F
LL
TA
N
MH
F
fig|679205.4.peg.2075
Escherichia coli MS 124-1 (5-760/760)
RNFPARQFHSL
----
TF
F
AG
LCI
G
ITPV
AQA
L
AAE
GQT
NAD
DTL
V
VEAS
T
PSL
Y
APQQSA
----
----------
DP
K
FSR
P
VA
D
T
TRT
MTV
I
S
E
Q
V
I
K
DQ
G
AT
NL
T
D
AL
K
N
V
PGV
G
AFF
A
G
EN
G
N
S
T
T
G
D
A
I
Y
M
-
RG
AD
TSNS
I
--
-
-
YIDGI
RD
-------
I
GS
----
V
SR
D
TFNT
E
Q
VEVI
K
GP
S
G
TD
YG
R
SAP
T
G
S
INM
I
SK
Q
P
R
N
DSG
I
-
D
A
SA
SI
GS
AWFR
R
GTL
D
VNQV
I
G
D
TT
AV
R
L
N
V
M
G
-E
K
T
H
DA
GR
D
KVKN
ERY
GV
AP
SVA
F
G
LG
TANR
L
YLN
----------
Y
L
HVT
QH
NTP
D
GGI
PT
I
G
LP
G
YS
A
P
SA
GT
AALN
--
H
SGK
V
D
THNFYGT
D
S
DY
D
D
STT
D
TAT
MR
--------
FEH
D
I
ND
N
T
T
I
R
N
T
T
RWS
R
VK
Q
D
Y
LM
TA
I
M
G
G
A
S
NITQ
P
TSDVN
S
W-
--------
-----------TWS
R
TANTK
D
VSN
K
I
L
TN
QT
N
L
T
S
T
F
Y
TG
S
I
G
H
D
V
S
---------------
TGV
E
F
T
R
--
-
ETQ
T
N
--------------------
Y
G
VN
---
P
VTL
P
AV
N
IYH
PD
-
--------S
S
IH
P
GGLTRNGA
N
ANG
QT
DTFA
I
YA
F
D
TL
Q
ITRD
F
E
L
N
GG
I
R
LD
N
Y
HTE
YD
S
AT
A
CGGSGRGAITCP
TGVAKGSPV
T
T
VDT
--
AKSG
N
LM
N
W
K
AG
AL
Y
H
L
T
E
NG
-
N
V
Y
I
N
YA
V
S
Q
Q
-----
P
PGGNNFALA
Q
S
GSG
---
N
S
A
N
RT
D
F
K
P
Q
K
A
N
T
S
EIG
T
K
WQVL
D
K
RL
LL
T
A
ALFR
TDIE
N
EVE
--------
Q
N
D
D
GTY
SQ
Y
--
G
KK
R
V
E
G
Y
EI
S
VA
---
G
N
IT
P
AWQV
I
GGYT
QQK
A
-
----
T
IK
NG
K
DV
AQ
DGSSSLPY
T
PEH
AFT
LWS
Q
Y
QAT
D
-
-
--
D
IS
VG
A
G
A
RY
I
G
---
S
MHKGS
D
-
G
A
V
GT
PA
F
TE
G
-
Y
W
V
A
DA
KL
G
Y
R
V
N
R
----
N
L
D
F
QLNV
Y
NLFD
TD
YVAS
INK
S
G
Y
-------
RYHP
G
E
PR
T
F
LL
TA
N
MH
F
fig|749540.3.peg.2741
Escherichia coli MS 146-1 (5-760/760)
RNFPARQFHSL
----
TF
F
AG
LCI
G
ITPV
AQA
L
AAE
GQT
NAD
DTL
V
VEAS
T
PSL
Y
APQQSA
----
----------
DP
K
FSR
P
VA
D
T
TRT
MTV
I
S
E
Q
V
I
K
DQ
G
AT
NL
T
D
AL
K
N
V
PGV
G
AFF
A
G
EN
G
N
S
T
T
G
D
A
I
Y
M
-
RG
AD
TSNS
I
--
-
-
YIDGI
RD
-------
I
GS
----
V
SR
D
TFNT
E
Q
VEVI
K
GP
S
G
TD
YG
R
SAP
T
G
S
INM
I
SK
Q
P
R
N
DSG
I
-
D
A
SA
SI
GS
AWFR
R
GTL
D
VNQV
I
G
D
TT
AV
R
L
N
V
M
G
-E
K
T
H
DA
GR
D
KVKN
ERY
GV
AP
SVA
F
G
LG
TANR
L
YLN
----------
Y
L
HVT
QH
NTP
D
GGI
PT
I
G
LP
G
YS
A
P
SA
GT
AALN
--
H
SGK
V
D
THNFYGT
D
S
DY
D
D
STT
D
TAT
MR
--------
FEH
D
I
ND
N
T
T
I
R
N
T
T
RWS
R
VK
Q
D
Y
LM
TA
I
M
G
G
A
S
NITQ
P
TSDVN
S
W-
--------
-----------TWS
R
TANTK
D
VSN
K
I
L
TN
QT
N
L
T
S
T
F
Y
TG
S
I
G
H
D
V
S
---------------
TGV
E
F
T
R
--
-
ETQ
T
N
--------------------
Y
G
VN
---
P
VTL
P
AV
N
IYH
PD
-
--------S
S
IH
P
GGLTRNGA
N
ANG
QT
DTFA
I
YA
F
D
TL
Q
ITRD
F
E
L
N
GG
I
R
LD
N
Y
HTE
YD
S
AT
A
CGGSGRGAITCP
TGVAKGSPV
T
T
VDT
--
AKSG
N
LM
N
W
K
AG
AL
Y
H
L
T
E
NG
-
N
V
Y
I
N
YA
V
S
Q
Q
-----
P
PGGNNFALA
Q
S
GSG
---
N
S
A
N
RT
D
F
K
P
Q
K
A
N
T
S
EIG
T
K
WQVL
D
K
RL
LL
T
A
ALFR
TDIE
N
EVE
--------
Q
N
D
D
GTY
SQ
Y
--
G
KK
R
V
E
G
Y
EI
S
VA
---
G
N
IT
P
AWQV
I
GGYT
QQK
A
-
----
T
IK
NG
K
DV
AQ
DGSSSLPY
T
PEH
AFT
LWS
Q
Y
QAT
D
-
-
--
D
IS
VG
A
G
A
RY
I
G
---
S
MHKGS
D
-
G
A
V
GT
PA
F
TE
G
-
Y
W
V
A
DA
KL
G
Y
R
V
N
R
----
N
L
D
F
QLNV
Y
NLFD
TD
YVAS
INK
S
G
Y
-------
RYHP
G
E
PR
T
F
LL
TA
N
MH
F
fig|749544.3.peg.2689
Escherichia coli MS 175-1 (5-760/760)
RNFPARQFHSL
----
TF
F
AG
LCI
G
ITPV
AQA
L
AAE
GQT
NAD
DTL
V
VEAS
T
PSL
Y
APQQSA
----
----------
DP
K
FSR
P
VA
D
T
TRT
MTV
I
S
E
Q
V
I
K
DQ
G
AT
NL
T
D
AL
K
N
V
PGV
G
AFF
A
G
EN
G
N
S
T
T
G
D
A
I
Y
M
-
RG
AD
TSNS
I
--
-
-
YIDGI
RD
-------
I
GS
----
V
SR
D
TFNT
E
Q
VEVI
K
GP
S
G
TD
YG
R
SAP
T
G
S
INM
I
SK
Q
P
R
N
DSG
I
-
D
A
SA
SI
GS
AWFR
R
GTL
D
VNQV
I
G
D
TT
AV
R
L
N
V
M
G
-E
K
T
H
DA
GR
D
KVKN
ERY
GV
AP
SVA
F
G
LG
TANR
L
YLN
----------
Y
L
HVT
QH
NTP
D
GGI
PT
I
G
LP
G
YS
A
P
SA
GT
AALN
--
H
SGK
V
D
THNFYGT
D
S
DY
D
D
STT
D
TAT
MR
--------
FEH
D
I
ND
N
T
T
I
R
N
T
T
RWS
R
VK
Q
D
Y
LM
TA
I
M
G
G
A
S
NITQ
P
TSDVN
S
W-
--------
-----------TWS
R
TANTK
D
VSN
K
I
L
TN
QT
N
L
T
S
T
F
Y
TG
S
I
G
H
D
V
S
---------------
TGV
E
F
T
R
--
-
ETQ
T
N
--------------------
Y
G
VN
---
P
VTL
P
AV
N
IYH
PD
-
--------S
S
IH
P
GGLTRNGA
N
ANG
QT
DTFA
I
YA
F
D
TL
Q
ITRD
F
E
L
N
GG
I
R
LD
N
Y
HTE
YD
S
AT
A
CGGSGRGAITCP
TGVAKGSPV
T
T
VDT
--
AKSG
N
LM
N
W
K
AG
AL
Y
H
L
T
E
NG
-
N
V
Y
I
N
YA
V
S
Q
Q
-----
P
PGGNNFALA
Q
S
GSG
---
N
S
A
N
RT
D
F
K
P
Q
K
A
N
T
S
EIG
T
K
WQVL
D
K
RL
LL
T
A
ALFR
TDIE
N
EVE
--------
Q
N
D
D
GTY
SQ
Y
--
G
KK
R
V
E
G
Y
EI
S
VA
---
G
N
IT
P
AWQV
I
GGYT
QQK
A
-
----
T
IK
NG
K
DV
AQ
DGSSSLPY
T
PEH
AFT
LWS
Q
Y
QAT
D
-
-
--
D
IS
VG
A
G
A
RY
I
G
---
S
MHKGS
D
-
G
A
V
GT
PA
F
TE
G
-
Y
W
V
A
DA
KL
G
Y
R
V
N
R
----
N
L
D
F
QLNV
Y
NLFD
TD
YVAS
INK
S
G
Y
-------
RYHP
G
E
PR
T
F
LL
TA
N
MH
F
fig|749533.3.peg.4816
Escherichia coli MS 84-1 (5-760/760)
RNFPARQFHSL
----
TF
F
AG
LCI
G
ITPV
AQA
L
AAE
GQT
NAD
DTL
V
VEAS
T
PSL
Y
APQQSA
----
----------
DP
K
FSR
P
VA
D
T
TRT
MTV
I
S
E
Q
V
I
K
DQ
G
AT
NL
T
D
AL
K
N
V
PGV
G
AFF
A
G
EN
G
N
S
T
T
G
D
A
I
Y
M
-
RG
AD
TSNS
I
--
-
-
YIDGI
RD
-------
I
GS
----
V
SR
D
TFNT
E
Q
VEVI
K
GP
S
G
TD
YG
R
SAP
T
G
S
INM
I
SK
Q
P
R
N
DSG
I
-
D
A
SA
SI
GS
AWFR
R
GTL
D
VNQV
I
G
D
TT
AV
R
L
N
V
M
G
-E
K
T
H
DA
GR
D
KVKN
ERY
GV
AP
SVA
F
G
LG
TANR
L
YLN
----------
Y
L
HVT
QH
NTP
D
GGI
PT
I
G
LP
G
YS
A
P
SA
GT
AALN
--
H
SGK
V
D
THNFYGT
D
S
DY
D
D
STT
D
TAT
MR
--------
FEH
D
I
ND
N
T
T
I
R
N
T
T
RWS
R
VK
Q
D
Y
LM
TA
I
M
G
G
A
S
NITQ
P
TSDVN
S
W-
--------
-----------TWS
R
TANTK
D
VSN
K
I
L
TN
QT
N
L
T
S
T
F
Y
TG
S
I
G
H
D
V
S
---------------
TGV
E
F
T
R
--
-
ETQ
T
N
--------------------
Y
G
VN
---
P
VTL
P
AV
N
IYH
PD
-
--------S
S
IH
P
GGLTRNGA
N
ANG
QT
DTFA
I
YA
F
D
TL
Q
ITRD
F
E
L
N
GG
I
R
LD
N
Y
HTE
YD
S
AT
A
CGGSGRGAITCP
TGVAKGSPV
T
T
VDT
--
AKSG
N
LM
N
W
K
AG
AL
Y
H
L
T
E
NG
-
N
V
Y
I
N
YA
V
S
Q
Q
-----
P
PGGNNFALA
Q
S
GSG
---
N
S
A
N
RT
D
F
K
P
Q
K
A
N
T
S
EIG
T
K
WQVL
D
K
RL
LL
T
A
ALFR
TDIE
N
EVE
--------
Q
N
D
D
GTY
SQ
Y
--
G
KK
R
V
E
G
Y
EI
S
VA
---
G
N
IT
P
AWQV
I
GGYT
QQK
A
-
----
T
IK
NG
K
DV
AQ
DGSSSLPY
T
PEH
AFT
LWS
Q
Y
QAT
D
-
-
--
D
IS
VG
A
G
A
RY
I
G
---
S
MHKGS
D
-
G
A
V
GT
PA
F
TE
G
-
Y
W
V
A
DA
KL
G
Y
R
V
N
R
----
N
L
D
F
QLNV
Y
NLFD
TD
YVAS
INK
S
G
Y
-------
RYHP
G
E
PR
T
F
LL
TA
N
MH
F
fig|316407.3.peg.772
Escherichia coli W3110 (5-760/760)
RNFPARQFHSL
----
TF
F
AG
LCI
G
ITPV
AQA
L
AAE
GQT
NAD
DTL
V
VEAS
T
PSL
Y
APQQSA
----
----------
DP
K
FSR
P
VA
D
T
TRT
MTV
I
S
E
Q
V
I
K
DQ
G
AT
NL
T
D
AL
K
N
V
PGV
G
AFF
A
G
EN
G
N
S
T
T
G
D
A
I
Y
M
-
RG
AD
TSNS
I
--
-
-
YIDGI
RD
-------
I
GS
----
V
SR
D
TFNT
E
Q
VEVI
K
GP
S
G
TD
YG
R
SAP
T
G
S
INM
I
SK
Q
P
R
N
DSG
I
-
D
A
SA
SI
GS
AWFR
R
GTL
D
VNQV
I
G
D
TT
AV
R
L
N
V
M
G
-E
K
T
H
DA
GR
D
KVKN
ERY
GV
AP
SVA
F
G
LG
TANR
L
YLN
----------
Y
L
HVT
QH
NTP
D
GGI
PT
I
G
LP
G
YS
A
P
SA
GT
AALN
--
H
SGK
V
D
THNFYGT
D
S
DY
D
D
STT
D
TAT
MR
--------
FEH
D
I
ND
N
T
T
I
R
N
T
T
RWS
R
VK
Q
D
Y
LM
TA
I
M
G
G
A
S
NITQ
P
TSDVN
S
W-
--------
-----------TWS
R
TANTK
D
VSN
K
I
L
TN
QT
N
L
T
S
T
F
Y
TG
S
I
G
H
D
V
S
---------------
TGV
E
F
T
R
--
-
ETQ
T
N
--------------------
Y
G
VN
---
P
VTL
P
AV
N
IYH
PD
-
--------S
S
IH
P
GGLTRNGA
N
ANG
QT
DTFA
I
YA
F
D
TL
Q
ITRD
F
E
L
N
GG
I
R
LD
N
Y
HTE
YD
S
AT
A
CGGSGRGAITCP
TGVAKGSPV
T
T
VDT
--
AKSG
N
LM
N
W
K
AG
AL
Y
H
L
T
E
NG
-
N
V
Y
I
N
YA
V
S
Q
Q
-----
P
PGGNNFALA
Q
S
GSG
---
N
S
A
N
RT
D
F
K
P
Q
K
A
N
T
S
EIG
T
K
WQVL
D
K
RL
LL
T
A
ALFR
TDIE
N
EVE
--------
Q
N
D
D
GTY
SQ
Y
--
G
KK
R
V
E
G
Y
EI
S
VA
---
G
N
IT
P
AWQV
I
GGYT
QQK
A
-
----
T
IK
NG
K
DV
AQ
DGSSSLPY
T
PEH
AFT
LWS
Q
Y
QAT
D
-
-
--
D
IS
VG
A
G
A
RY
I
G
---
S
MHKGS
D
-
G
A
V
GT
PA
F
TE
G
-
Y
W
V
A
DA
KL
G
Y
R
V
N
R
----
N
L
D
F
QLNV
Y
NLFD
TD
YVAS
INK
S
G
Y
-------
RYHP
G
E
PR
T
F
LL
TA
N
MH
F
fig|316385.7.peg.881
Escherichia coli str. K-12 substr. DH10B (5-760/760)
RNFPARQFHSL
----
TF
F
AG
LCI
G
ITPV
AQA
L
AAE
GQT
NAD
DTL
V
VEAS
T
PSL
Y
APQQSA
----
----------
DP
K
FSR
P
VA
D
T
TRT
MTV
I
S
E
Q
V
I
K
DQ
G
AT
NL
T
D
AL
K
N
V
PGV
G
AFF
A
G
EN
G
N
S
T
T
G
D
A
I
Y
M
-
RG
AD
TSNS
I
--
-
-
YIDGI
RD
-------
I
GS
----
V
SR
D
TFNT
E
Q
VEVI
K
GP
S
G
TD
YG
R
SAP
T
G
S
INM
I
SK
Q
P
R
N
DSG
I
-
D
A
SA
SI
GS
AWFR
R
GTL
D
VNQV
I
G
D
TT
AV
R
L
N
V
M
G
-E
K
T
H
DA
GR
D
KVKN
ERY
GV
AP
SVA
F
G
LG
TANR
L
YLN
----------
Y
L
HVT
QH
NTP
D
GGI
PT
I
G
LP
G
YS
A
P
SA
GT
AALN
--
H
SGK
V
D
THNFYGT
D
S
DY
D
D
STT
D
TAT
MR
--------
FEH
D
I
ND
N
T
T
I
R
N
T
T
RWS
R
VK
Q
D
Y
LM
TA
I
M
G
G
A
S
NITQ
P
TSDVN
S
W-
--------
-----------TWS
R
TANTK
D
VSN
K
I
L
TN
QT
N
L
T
S
T
F
Y
TG
S
I
G
H
D
V
S
---------------
TGV
E
F
T
R
--
-
ETQ
T
N
--------------------
Y
G
VN
---
P
VTL
P
AV
N
IYH
PD
-
--------S
S
IH
P
GGLTRNGA
N
ANG
QT
DTFA
I
YA
F
D
TL
Q
ITRD
F
E
L
N
GG
I
R
LD
N
Y
HTE
YD
S
AT
A
CGGSGRGAITCP
TGVAKGSPV
T
T
VDT
--
AKSG
N
LM
N
W
K
AG
AL
Y
H
L
T
E
NG
-
N
V
Y
I
N
YA
V
S
Q
Q
-----
P
PGGNNFALA
Q
S
GSG
---
N
S
A
N
RT
D
F
K
P
Q
K
A
N
T
S
EIG
T
K
WQVL
D
K
RL
LL
T
A
ALFR
TDIE
N
EVE
--------
Q
N
D
D
GTY
SQ
Y
--
G
KK
R
V
E
G
Y
EI
S
VA
---
G
N
IT
P
AWQV
I
GGYT
QQK
A
-
----
T
IK
NG
K
DV
AQ
DGSSSLPY
T
PEH
AFT
LWS
Q
Y
QAT
D
-
-
--
D
IS
VG
A
G
A
RY
I
G
---
S
MHKGS
D
-
G
A
V
GT
PA
F
TE
G
-
Y
W
V
A
DA
KL
G
Y
R
V
N
R
----
N
L
D
F
QLNV
Y
NLFD
TD
YVAS
INK
S
G
Y
-------
RYHP
G
E
PR
T
F
LL
TA
N
MH
F
fig|511145.12.peg.832
Escherichia coli str. K-12 substr. MG1655 (5-760/760)
RNFPARQFHSL
----
TF
F
AG
LCI
G
ITPV
AQA
L
AAE
GQT
NAD
DTL
V
VEAS
T
PSL
Y
APQQSA
----
----------
DP
K
FSR
P
VA
D
T
TRT
MTV
I
S
E
Q
V
I
K
DQ
G
AT
NL
T
D
AL
K
N
V
PGV
G
AFF
A
G
EN
G
N
S
T
T
G
D
A
I
Y
M
-
RG
AD
TSNS
I
--
-
-
YIDGI
RD
-------
I
GS
----
V
SR
D
TFNT
E
Q
VEVI
K
GP
S
G
TD
YG
R
SAP
T
G
S
INM
I
SK
Q
P
R
N
DSG
I
-
D
A
SA
SI
GS
AWFR
R
GTL
D
VNQV
I
G
D
TT
AV
R
L
N
V
M
G
-E
K
T
H
DA
GR
D
KVKN
ERY
GV
AP
SVA
F
G
LG
TANR
L
YLN
----------
Y
L
HVT
QH
NTP
D
GGI
PT
I
G
LP
G
YS
A
P
SA
GT
AALN
--
H
SGK
V
D
THNFYGT
D
S
DY
D
D
STT
D
TAT
MR
--------
FEH
D
I
ND
N
T
T
I
R
N
T
T
RWS
R
VK
Q
D
Y
LM
TA
I
M
G
G
A
S
NITQ
P
TSDVN
S
W-
--------
-----------TWS
R
TANTK
D
VSN
K
I
L
TN
QT
N
L
T
S
T
F
Y
TG
S
I
G
H
D
V
S
---------------
TGV
E
F
T
R
--
-
ETQ
T
N
--------------------
Y
G
VN
---
P
VTL
P
AV
N
IYH
PD
-
--------S
S
IH
P
GGLTRNGA
N
ANG
QT
DTFA
I
YA
F
D
TL
Q
ITRD
F
E
L
N
GG
I
R
LD
N
Y
HTE
YD
S
AT
A
CGGSGRGAITCP
TGVAKGSPV
T
T
VDT
--
AKSG
N
LM
N
W
K
AG
AL
Y
H
L
T
E
NG
-
N
V
Y
I
N
YA
V
S
Q
Q
-----
P
PGGNNFALA
Q
S
GSG
---
N
S
A
N
RT
D
F
K
P
Q
K
A
N
T
S
EIG
T
K
WQVL
D
K
RL
LL
T
A
ALFR
TDIE
N
EVE
--------
Q
N
D
D
GTY
SQ
Y
--
G
KK
R
V
E
G
Y
EI
S
VA
---
G
N
IT
P
AWQV
I
GGYT
QQK
A
-
----
T
IK
NG
K
DV
AQ
DGSSSLPY
T
PEH
AFT
LWS
Q
Y
QAT
D
-
-
--
D
IS
VG
A
G
A
RY
I
G
---
S
MHKGS
D
-
G
A
V
GT
PA
F
TE
G
-
Y
W
V
A
DA
KL
G
Y
R
V
N
R
----
N
L
D
F
QLNV
Y
NLFD
TD
YVAS
INK
S
G
Y
-------
RYHP
G
E
PR
T
F
LL
TA
N
MH
F
fig|511145.6.peg.824
Escherichia coli str. K-12 substr. MG1655 (5-760/760)
RNFPARQFHSL
----
TF
F
AG
LCI
G
ITPV
AQA
L
AAE
GQT
NAD
DTL
V
VEAS
T
PSL
Y
APQQSA
----
----------
DP
K
FSR
P
VA
D
T
TRT
MTV
I
S
E
Q
V
I
K
DQ
G
AT
NL
T
D
AL
K
N
V
PGV
G
AFF
A
G
EN
G
N
S
T
T
G
D
A
I
Y
M
-
RG
AD
TSNS
I
--
-
-
YIDGI
RD
-------
I
GS
----
V
SR
D
TFNT
E
Q
VEVI
K
GP
S
G
TD
YG
R
SAP
T
G
S
INM
I
SK
Q
P
R
N
DSG
I
-
D
A
SA
SI
GS
AWFR
R
GTL
D
VNQV
I
G
D
TT
AV
R
L
N
V
M
G
-E
K
T
H
DA
GR
D
KVKN
ERY
GV
AP
SVA
F
G
LG
TANR
L
YLN
----------
Y
L
HVT
QH
NTP
D
GGI
PT
I
G
LP
G
YS
A
P
SA
GT
AALN
--
H
SGK
V
D
THNFYGT
D
S
DY
D
D
STT
D
TAT
MR
--------
FEH
D
I
ND
N
T
T
I
R
N
T
T
RWS
R
VK
Q
D
Y
LM
TA
I
M
G
G
A
S
NITQ
P
TSDVN
S
W-
--------
-----------TWS
R
TANTK
D
VSN
K
I
L
TN
QT
N
L
T
S
T
F
Y
TG
S
I
G
H
D
V
S
---------------
TGV
E
F
T
R
--
-
ETQ
T
N
--------------------
Y
G
VN
---
P
VTL
P
AV
N
IYH
PD
-
--------S
S
IH
P
GGLTRNGA
N
ANG
QT
DTFA
I
YA
F
D
TL
Q
ITRD
F
E
L
N
GG
I
R
LD
N
Y
HTE
YD
S
AT
A
CGGSGRGAITCP
TGVAKGSPV
T
T
VDT
--
AKSG
N
LM
N
W
K
AG
AL
Y
H
L
T
E
NG
-
N
V
Y
I
N
YA
V
S
Q
Q
-----
P
PGGNNFALA
Q
S
GSG
---
N
S
A
N
RT
D
F
K
P
Q
K
A
N
T
S
EIG
T
K
WQVL
D
K
RL
LL
T
A
ALFR
TDIE
N
EVE
--------
Q
N
D
D
GTY
SQ
Y
--
G
KK
R
V
E
G
Y
EI
S
VA
---
G
N
IT
P
AWQV
I
GGYT
QQK
A
-
----
T
IK
NG
K
DV
AQ
DGSSSLPY
T
PEH
AFT
LWS
Q
Y
QAT
D
-
-
--
D
IS
VG
A
G
A
RY
I
G
---
S
MHKGS
D
-
G
A
V
GT
PA
F
TE
G
-
Y
W
V
A
DA
KL
G
Y
R
V
N
R
----
N
L
D
F
QLNV
Y
NLFD
TD
YVAS
INK
S
G
Y
-------
RYHP
G
E
PR
T
F
LL
TA
N
MH
F
fig|340184.3.peg.1201
Escherichia coli B7A (5-760/760)
RNFPARQFHSL
----
TF
F
AG
LCI
G
ITPV
AQA
L
AAE
GQT
NAD
DTL
V
VEAS
T
PSL
Y
APQQSA
----
----------
DP
K
FSR
P
VA
D
T
TRT
MTV
I
S
E
Q
V
I
K
DQ
G
AT
NL
I
D
AL
K
N
V
PGV
G
AFF
A
G
EN
G
N
S
T
T
G
D
A
I
Y
M
-
RG
AD
TSNS
I
--
-
-
YIDGI
RD
-------
I
GS
----
V
SR
D
TFNT
E
Q
VEVI
K
GP
S
G
TD
YG
R
SAP
T
G
S
INM
I
SK
Q
P
R
N
DSG
I
-
D
A
SA
SI
GS
AWFR
R
GTL
D
VNQV
I
G
D
TT
AV
R
L
N
V
M
G
-E
K
T
H
DA
GR
D
KVKN
ERY
GV
AP
SIA
F
G
LG
TANR
L
YLN
----------
Y
L
HVT
QH
NTP
D
GGI
PT
I
G
LP
G
YS
A
P
SA
GT
AALN
--
H
SGK
V
D
THNFYGT
D
S
DY
D
D
STT
D
TAT
MR
--------
FEH
D
I
ND
N
T
T
I
R
N
T
T
RWS
R
VK
Q
D
Y
LM
TA
I
M
G
G
A
S
NITQ
P
TSDVN
S
W-
--------
-----------TWS
R
TANTK
D
VSN
K
I
L
TN
QT
N
L
T
S
T
F
Y
TG
S
I
G
H
D
V
S
---------------
TGV
E
F
T
R
--
-
ETQ
T
N
--------------------
Y
G
VN
---
P
VTL
P
AV
N
IYH
PD
-
--------S
S
IH
P
GGLTRNGA
N
ANG
QT
DTFA
I
YA
F
D
TL
Q
ITRD
F
E
L
N
GG
I
R
LD
N
Y
HTE
YD
S
AT
A
CGGSGRGAITCP
AGVAKGSPV
T
T
VDT
--
AKSG
N
LV
N
W
K
AG
AL
Y
H
L
T
E
NG
-
N
V
Y
I
N
YA
V
S
Q
Q
-----
P
PGGNNFALA
Q
S
GSG
---
N
S
A
N
RT
D
F
K
P
Q
K
A
N
T
S
EIG
T
K
WQVL
D
K
RL
LL
T
A
ALFR
TDIE
N
EVE
--------
Q
N
D
D
GTY
SQ
Y
--
G
KK
R
V
E
G
Y
EI
S
VA
---
G
N
IT
P
AWQV
I
GGYT
QQK
A
-
----
T
IK
NG
K
DV
AQ
DGSSSLPY
T
PEH
AFT
LWS
Q
Y
QAT
D
-
-
--
D
IS
VG
A
G
A
RY
I
G
---
S
MHKGS
D
-
G
A
V
GT
PA
F
TE
G
-
Y
W
V
A
DA
KL
G
Y
R
V
N
R
----
N
L
D
F
QLNV
Y
NLFD
TD
YVAS
INK
S
G
Y
-------
RYHP
G
E
PR
T
F
LL
TA
N
MH
F
fig|340184.6.peg.1264
Escherichia coli B7A (5-760/760)
RNFPARQFHSL
----
TF
F
AG
LCI
G
ITPV
AQA
L
AAE
GQT
NAD
DTL
V
VEAS
T
PSL
Y
APQQSA
----
----------
DP
K
FSR
P
VA
D
T
TRT
MTV
I
S
E
Q
V
I
K
DQ
G
AT
NL
I
D
AL
K
N
V
PGV
G
AFF
A
G
EN
G
N
S
T
T
G
D
A
I
Y
M
-
RG
AD
TSNS
I
--
-
-
YIDGI
RD
-------
I
GS
----
V
SR
D
TFNT
E
Q
VEVI
K
GP
S
G
TD
YG
R
SAP
T
G
S
INM
I
SK
Q
P
R
N
DSG
I
-
D
A
SA
SI
GS
AWFR
R
GTL
D
VNQV
I
G
D
TT
AV
R
L
N
V
M
G
-E
K
T
H
DA
GR
D
KVKN
ERY
GV
AP
SIA
F
G
LG
TANR
L
YLN
----------
Y
L
HVT
QH
NTP
D
GGI
PT
I
G
LP
G
YS
A
P
SA
GT
AALN
--
H
SGK
V
D
THNFYGT
D
S
DY
D
D
STT
D
TAT
MR
--------
FEH
D
I
ND
N
T
T
I
R
N
T
T
RWS
R
VK
Q
D
Y
LM
TA
I
M
G
G
A
S
NITQ
P
TSDVN
S
W-
--------
-----------TWS
R
TANTK
D
VSN
K
I
L
TN
QT
N
L
T
S
T
F
Y
TG
S
I
G
H
D
V
S
---------------
TGV
E
F
T
R
--
-
ETQ
T
N
--------------------
Y
G
VN
---
P
VTL
P
AV
N
IYH
PD
-
--------S
S
IH
P
GGLTRNGA
N
ANG
QT
DTFA
I
YA
F
D
TL
Q
ITRD
F
E
L
N
GG
I
R
LD
N
Y
HTE
YD
S
AT
A
CGGSGRGAITCP
AGVAKGSPV
T
T
VDT
--
AKSG
N
LV
N
W
K
AG
AL
Y
H
L
T
E
NG
-
N
V
Y
I
N
YA
V
S
Q
Q
-----
P
PGGNNFALA
Q
S
GSG
---
N
S
A
N
RT
D
F
K
P
Q
K
A
N
T
S
EIG
T
K
WQVL
D
K
RL
LL
T
A
ALFR
TDIE
N
EVE
--------
Q
N
D
D
GTY
SQ
Y
--
G
KK
R
V
E
G
Y
EI
S
VA
---
G
N
IT
P
AWQV
I
GGYT
QQK
A
-
----
T
IK
NG
K
DV
AQ
DGSSSLPY
T
PEH
AFT
LWS
Q
Y
QAT
D
-
-
--
D
IS
VG
A
G
A
RY
I
G
---
S
MHKGS
D
-
G
A
V
GT
PA
F
TE
G
-
Y
W
V
A
DA
KL
G
Y
R
V
N
R
----
N
L
D
F
QLNV
Y
NLFD
TD
YVAS
INK
S
G
Y
-------
RYHP
G
E
PR
T
F
LL
TA
N
MH
F
fig|1040638.4.peg.4914
Escherichia coli O104:H4 str. LB226692 (5-760/760)
RNFPARQFHSL
----
TF
F
AG
LCI
G
ITPV
AQA
L
AAE
GQT
NAD
DTL
V
VEAS
T
PSL
Y
APQQSA
----
----------
DP
K
FSR
P
VA
D
T
TRT
MTV
I
S
E
Q
V
I
K
DQ
G
AT
NL
T
D
AL
K
N
V
PGV
G
AFF
A
G
EN
G
N
S
T
T
G
D
A
I
Y
M
-
RG
AD
TSNS
I
--
-
-
YIDGI
RD
-------
I
GS
----
V
SR
D
TFNT
E
Q
VEVI
K
GP
S
G
TD
YG
R
SAP
T
G
S
INM
I
SK
Q
P
R
N
DSG
I
-
D
A
SA
SI
GS
AWFR
R
GTL
D
VNQV
I
G
D
TT
AV
R
L
N
V
M
G
-E
K
T
H
DA
GR
D
KVKN
ERY
GV
AP
SIA
F
G
LG
TANR
L
YLN
----------
Y
L
HVT
QH
NTP
D
GGI
PT
I
G
LP
G
YS
A
P
SA
GT
AALN
--
H
SGK
V
D
THNFYGT
D
S
DY
D
D
STT
D
TAT
MR
--------
FEH
D
I
ND
N
T
T
I
R
N
T
T
RWS
R
VK
Q
D
Y
LM
TA
I
M
G
G
A
S
NITQ
P
TSDVN
S
W-
--------
-----------TWS
R
TANTK
D
VSN
K
I
L
TN
QT
N
L
T
S
T
F
Y
TG
S
I
G
H
D
V
S
---------------
TGV
E
F
T
R
--
-
ETQ
T
N
--------------------
Y
G
VN
---
P
VTL
P
AV
N
IYH
PD
-
--------S
S
IH
P
GGLTRNGA
N
ANG
QT
DTFA
I
YA
F
D
TL
Q
ITRD
F
E
L
N
GG
I
R
LD
N
Y
HTE
YD
S
AT
A
CGGSGRGAITCP
TGVAKGSPV
T
T
VDT
--
AKSG
N
LV
N
W
K
AG
AL
Y
H
L
T
E
NG
-
N
V
Y
I
N
YA
V
S
Q
Q
-----
P
PGGNNFALA
Q
S
GSG
---
N
S
A
N
RT
D
F
K
P
Q
K
A
N
T
S
EIG
T
K
WQVL
D
K
RL
LL
T
A
ALFR
TDIE
N
EVE
--------
Q
N
D
D
GTY
SQ
Y
--
G
KK
R
V
E
G
Y
EI
S
VA
---
G
N
IT
P
AWQV
I
GGYT
QQK
A
-
----
T
IK
NG
K
DV
AQ
DGSSSLPY
T
PEH
AFT
LWS
Q
Y
QAT
D
-
-
--
D
IS
VG
A
G
A
RY
I
G
---
S
MHKGS
D
-
G
A
V
GT
PA
F
TE
G
-
Y
W
V
A
DA
KL
G
Y
R
V
N
R
----
N
L
D
F
QLNV
Y
NLFD
TD
YVAS
INK
S
G
Y
-------
RYHP
G
E
PR
T
F
LL
TA
N
MH
F
fig|585055.6.peg.859
Escherichia coli 55989 (5-760/760)
RNFPARQFHSL
----
TF
F
AG
LCI
G
ITPV
AQA
L
AAE
GQT
NAD
DTL
V
VEAS
T
PSL
Y
APQQSA
----
----------
DP
K
FSR
P
VA
D
T
TRT
MTV
I
S
E
Q
V
I
K
DQ
G
AT
NL
T
D
AL
K
N
V
PGV
G
AFF
A
G
EN
G
N
S
T
T
G
D
A
I
Y
M
-
RG
AD
TSNS
I
--
-
-
YIDGI
RD
-------
I
GS
----
V
SR
D
TFNT
E
Q
VEVI
K
GP
S
G
TD
YG
R
SAP
T
G
S
INM
I
SK
Q
P
R
N
DSG
I
-
D
A
SA
SI
GS
AWFR
R
GTL
D
VNQV
I
G
D
TT
AV
R
L
N
V
M
G
-E
K
T
H
DA
GR
D
KVKN
ERY
GV
AP
SIA
F
G
LG
TANR
L
YLN
----------
Y
L
HVT
QH
NTP
D
GGI
PT
I
G
LP
G
YS
A
P
SA
GT
AALN
--
H
SGK
V
D
THNFYGT
D
S
DY
D
D
STT
D
TAT
MR
--------
FEH
D
I
ND
N
T
T
I
R
N
T
T
RWS
R
VK
Q
D
Y
LM
TA
I
M
G
G
A
S
NITQ
P
TSDVN
S
W-
--------
-----------TWS
R
TANTK
D
VSN
K
I
L
TN
QT
N
L
T
S
T
F
Y
TG
S
I
G
H
D
V
S
---------------
TGV
E
F
T
R
--
-
ETQ
T
N
--------------------
Y
G
VN
---
P
VTL
P
AV
N
IYH
PD
-
--------S
S
IH
P
GGLTRNGA
N
ANG
QT
DTFA
I
YA
F
D
TL
Q
ITRD
F
E
L
N
GG
I
R
LD
N
Y
HTE
YD
S
AT
A
CGGSGRGAITCP
TGVAKGSPV
T
T
VDT
--
AKSG
N
LV
N
W
K
AG
AL
Y
H
L
T
E
NG
-
N
V
Y
I
N
YA
V
S
Q
Q
-----
P
PGGNNFALA
Q
S
GSG
---
N
S
A
N
RT
D
F
K
P
Q
K
A
N
T
S
EIG
T
K
WQVL
D
K
RL
LL
T
A
ALFR
TDIE
N
EVE
--------
Q
N
D
D
GTY
SQ
Y
--
G
KK
R
V
E
G
Y
EI
S
VA
---
G
N
IT
P
AWQV
I
GGYT
QQK
A
-
----
T
IK
NG
K
DV
AQ
DGSSSLPY
T
PEH
AFT
LWS
Q
Y
QAT
D
-
-
--
D
IS
VG
A
G
A
RY
I
G
---
S
MHKGS
D
-
G
A
V
GT
PA
F
TE
G
-
Y
W
V
A
DA
KL
G
Y
R
V
N
R
----
N
L
D
F
QLNV
Y
NLFD
TD
YVAS
INK
S
G
Y
-------
RYHP
G
E
PR
T
F
LL
TA
N
MH
F
fig|585055.8.peg.863
Escherichia coli 55989 (5-760/760)
RNFPARQFHSL
----
TF
F
AG
LCI
G
ITPV
AQA
L
AAE
GQT
NAD
DTL
V
VEAS
T
PSL
Y
APQQSA
----
----------
DP
K
FSR
P
VA
D
T
TRT
MTV
I
S
E
Q
V
I
K
DQ
G
AT
NL
T
D
AL
K
N
V
PGV
G
AFF
A
G
EN
G
N
S
T
T
G
D
A
I
Y
M
-
RG
AD
TSNS
I
--
-
-
YIDGI
RD
-------
I
GS
----
V
SR
D
TFNT
E
Q
VEVI
K
GP
S
G
TD
YG
R
SAP
T
G
S
INM
I
SK
Q
P
R
N
DSG
I
-
D
A
SA
SI
GS
AWFR
R
GTL
D
VNQV
I
G
D
TT
AV
R
L
N
V
M
G
-E
K
T
H
DA
GR
D
KVKN
ERY
GV
AP
SIA
F
G
LG
TANR
L
YLN
----------
Y
L
HVT
QH
NTP
D
GGI
PT
I
G
LP
G
YS
A
P
SA
GT
AALN
--
H
SGK
V
D
THNFYGT
D
S
DY
D
D
STT
D
TAT
MR
--------
FEH
D
I
ND
N
T
T
I
R
N
T
T
RWS
R
VK
Q
D
Y
LM
TA
I
M
G
G
A
S
NITQ
P
TSDVN
S
W-
--------
-----------TWS
R
TANTK
D
VSN
K
I
L
TN
QT
N
L
T
S
T
F
Y
TG
S
I
G
H
D
V
S
---------------
TGV
E
F
T
R
--
-
ETQ
T
N
--------------------
Y
G
VN
---
P
VTL
P
AV
N
IYH
PD
-
--------S
S
IH
P
GGLTRNGA
N
ANG
QT
DTFA
I
YA
F
D
TL
Q
ITRD
F
E
L
N
GG
I
R
LD
N
Y
HTE
YD
S
AT
A
CGGSGRGAITCP
TGVAKGSPV
T
T
VDT
--
AKSG
N
LV
N
W
K
AG
AL
Y
H
L
T
E
NG
-
N
V
Y
I
N
YA
V
S
Q
Q
-----
P
PGGNNFALA
Q
S
GSG
---
N
S
A
N
RT
D
F
K
P
Q
K
A
N
T
S
EIG
T
K
WQVL
D
K
RL
LL
T
A
ALFR
TDIE
N
EVE
--------
Q
N
D
D
GTY
SQ
Y
--
G
KK
R
V
E
G
Y
EI
S
VA
---
G
N
IT
P
AWQV
I
GGYT
QQK
A
-
----
T
IK
NG
K
DV
AQ
DGSSSLPY
T
PEH
AFT
LWS
Q
Y
QAT
D
-
-
--
D
IS
VG
A
G
A
RY
I
G
---
S
MHKGS
D
-
G
A
V
GT
PA
F
TE
G
-
Y
W
V
A
DA
KL
G
Y
R
V
N
R
----
N
L
D
F
QLNV
Y
NLFD
TD
YVAS
INK
S
G
Y
-------
RYHP
G
E
PR
T
F
LL
TA
N
MH
F
fig|340186.3.peg.2581
Escherichia coli E110019 (5-760/760)
RNFPARQFHSL
----
TF
F
AG
LCI
G
ITPV
AQA
L
AAE
GQT
NAD
DTL
V
VEAS
T
PSL
Y
APQQSA
----
----------
DP
K
FSR
P
VA
D
T
TRT
MTV
I
S
E
Q
V
I
K
DQ
G
AT
NL
T
D
AL
K
N
V
PGV
G
AFF
A
G
EN
G
N
S
T
T
G
D
A
I
Y
M
-
RG
AD
TSNS
I
--
-
-
YIDGI
RD
-------
I
GS
----
V
SR
D
TFNT
E
Q
VEVI
K
GP
S
G
TD
YG
R
SAP
T
G
S
INM
I
SK
Q
P
R
N
DSG
I
-
D
A
SA
SI
GS
AWFR
R
GTL
D
VNQV
I
G
D
TT
AV
R
L
N
V
M
G
-E
K
T
H
DA
GR
D
KVKN
ERY
GV
AP
SIA
F
G
LG
TANR
L
YLN
----------
Y
L
HVT
QH
NTP
D
GGI
PT
I
G
LP
G
YS
A
P
SA
GT
AALN
--
H
SGK
V
D
THNFYGT
D
S
DY
D
D
STT
D
TAT
MR
--------
FEH
D
I
ND
N
T
T
I
R
N
T
T
RWS
R
VK
Q
D
Y
LM
TA
I
M
G
G
A
S
NITQ
P
TSDVN
S
W-
--------
-----------TWS
R
TANTK
D
VSN
K
I
L
TN
QT
N
L
T
S
T
F
Y
TG
S
I
G
H
D
V
S
---------------
TGV
E
F
T
R
--
-
ETQ
T
N
--------------------
Y
G
VN
---
P
VTL
P
AV
N
IYH
PD
-
--------S
S
IH
P
GGLTRNGA
N
ANG
QT
DTFA
I
YA
F
D
TL
Q
ITRD
F
E
L
N
GG
I
R
LD
N
Y
HTE
YD
S
AT
A
CGGSGRGAITCP
TGVAKGSPV
T
T
VDT
--
AKSG
N
LV
N
W
K
AG
AL
Y
H
L
T
E
NG
-
N
V
Y
I
N
YA
V
S
Q
Q
-----
P
PGGNNFALA
Q
S
GSG
---
N
S
A
N
RT
D
F
K
P
Q
K
A
N
T
S
EIG
T
K
WQVL
D
K
RL
LL
T
A
ALFR
TDIE
N
EVE
--------
Q
N
D
D
GTY
SQ
Y
--
G
KK
R
V
E
G
Y
EI
S
VA
---
G
N
IT
P
AWQV
I
GGYT
QQK
A
-
----
T
IK
NG
K
DV
AQ
DGSSSLPY
T
PEH
AFT
LWS
Q
Y
QAT
D
-
-
--
D
IS
VG
A
G
A
RY
I
G
---
S
MHKGS
D
-
G
A
V
GT
PA
F
TE
G
-
Y
W
V
A
DA
KL
G
Y
R
V
N
R
----
N
L
D
F
QLNV
Y
NLFD
TD
YVAS
INK
S
G
Y
-------
RYHP
G
E
PR
T
F
LL
TA
N
MH
F
fig|656417.3.peg.991
Escherichia coli M605 (5-760/760)
RNFPARQFHSL
----
TF
F
AG
LCI
G
ITPV
AQA
L
AAE
GQA
NAD
DTL
V
VEAS
T
PSL
Y
APQ
K
SA
----
----------
DP
K
FSR
P
VA
D
T
TRT
MTV
I
S
E
Q
V
I
K
DQ
G
AT
NL
T
D
AL
K
N
V
PGV
G
AFF
A
G
EN
G
N
S
T
T
G
D
A
I
Y
M
-
RG
AD
TSNS
I
--
-
-
YIDGI
RD
-------
I
GS
----
V
SR
D
TFNT
E
Q
VEVI
K
GP
S
G
TD
YG
R
SAP
T
G
S
INM
I
SK
Q
P
R
N
DSG
I
-
D
A
SA
SI
GS
AWFR
R
GTL
D
VNQV
I
G
D
TT
AV
R
L
N
V
M
G
-E
K
T
H
DA
GR
D
KVKN
ERY
GV
AP
SVA
F
G
LG
TANR
L
YLN
----------
Y
L
HVT
QH
NTP
D
GGI
PT
I
G
LP
G
YS
A
P
SA
GT
AALN
--
H
SGK
V
D
THNFYGT
D
S
DY
D
D
STT
D
TAT
MR
--------
FEH
D
I
ND
N
T
T
I
R
N
T
T
RWS
R
VK
Q
D
Y
LM
TA
I
M
G
G
A
S
NITQ
P
ASDVN
S
W-
--------
-----------TWS
R
TANTK
D
VSN
K
I
L
TN
QT
N
L
T
S
T
F
Y
TG
A
I
G
H
D
V
S
---------------
TGV
E
F
T
R
--
-
ETQ
T
N
--------------------
Y
G
VN
---
P
VTL
P
AV
N
IYH
PD
-
--------S
S
IH
P
GGLTRNGA
N
ANG
QT
DTFA
I
YA
F
D
TL
Q
ITRD
F
E
L
N
GG
I
R
LD
N
Y
HTE
YD
S
AT
A
CGGSGRGAITCP
AGVAKGSPV
T
T
VDT
--
AKSG
N
LV
N
W
K
AG
AL
Y
H
L
T
E
NG
-
N
V
Y
I
N
YA
V
S
Q
Q
-----
P
PGGNNFALA
Q
S
GSG
---
N
S
A
N
RT
D
F
K
P
Q
K
A
N
T
S
EIG
T
K
WQVL
D
K
RL
LL
T
A
ALFR
TDIE
N
EVE
--------
Q
N
D
D
GTY
SQ
Y
--
G
KK
R
V
E
G
Y
EI
S
VA
---
G
N
IT
P
AWQ
M
I
GGYT
QQK
A
-
----
T
IK
NG
K
DV
AQ
DGSSSLPY
T
PEH
AFT
LWS
Q
Y
QAT
D
-
-
--
D
IS
VG
A
G
A
RY
I
G
---
S
MHKGS
D
-
G
A
V
GT
PA
F
TE
G
-
Y
W
V
A
DA
KL
G
Y
R
V
N
R
----
N
L
D
F
QLNV
Y
NLFD
TD
YVAS
INK
S
G
Y
-------
RYHP
G
E
PR
T
F
LL
TA
N
MH
F
fig|685038.3.peg.731
Escherichia coli O83:H1 str. NRG 857C (5-760/760)
RNFPARQFHSL
----
TF
F
AG
LCI
G
ITPV
AQA
L
AAE
GQA
NAD
DTL
V
VEAS
T
PSL
Y
APQQSA
----
----------
DP
K
FSR
P
VA
D
T
TRT
MTV
I
S
E
Q
V
I
K
DQ
G
AT
NL
T
D
AL
K
N
V
PGV
G
AFF
A
G
EN
G
N
S
T
T
G
D
A
I
Y
M
-
RG
AD
TSNS
I
--
-
-
YIDGI
RD
-------
I
GS
----
V
SR
D
TFNT
E
Q
VEVI
K
GP
S
G
TD
YG
R
SAP
T
G
S
INM
I
SK
Q
P
R
N
DSG
I
-
D
A
SA
SI
GS
AWFR
R
GTL
D
VNQV
I
G
D
TT
AM
R
L
N
V
M
G
-E
K
T
H
DA
GR
D
KVKN
ERY
GV
AP
SVA
F
G
LG
TANR
L
YLN
----------
Y
L
HVT
QH
NTP
D
GGI
PT
I
G
LP
G
YS
A
P
SA
GT
AALN
--
H
SGK
V
D
THNFYGT
D
S
DY
D
D
SIT
D
TAT
MR
--------
FEH
D
I
ND
N
T
T
I
R
N
T
T
RWS
R
VK
Q
D
Y
LM
TA
I
M
G
G
A
S
NITQ
P
TSDVN
S
W-
--------
-----------TWS
R
TANTK
D
VSN
K
I
L
TN
QT
N
L
T
S
T
F
Y
TG
A
I
G
H
D
L
S
---------------
TGV
E
F
T
R
--
-
ETQ
T
N
--------------------
Y
G
VN
---
P
VTL
P
AV
N
IYH
PD
-
--------S
S
IH
P
GGLTRNGA
N
ANG
QT
DTFA
I
YA
F
D
TL
Q
ITRD
F
E
L
N
GG
I
R
LD
N
Y
HTE
YD
S
AT
A
CGGSGRGAITCP
AGVAKGSPV
T
T
VDT
--
AKSG
N
LV
N
W
K
AG
AL
Y
H
L
T
E
NG
-
N
V
Y
I
N
YA
V
S
Q
Q
-----
P
PGGNNFALA
Q
S
GSG
---
N
S
A
N
RT
D
F
K
P
Q
K
A
N
T
S
EIG
T
K
WQVL
D
K
RL
LL
T
A
ALFR
TDIE
N
EVE
--------
Q
N
D
D
GTY
SQ
Y
--
G
KK
R
V
E
G
Y
EI
S
VA
---
G
N
IT
P
AWQ
M
I
GGYT
QQK
A
-
----
T
IK
NG
K
DV
AQ
DGSSSLPY
T
PEH
AFT
LWS
Q
Y
QAT
D
-
-
--
D
IS
VG
A
G
A
RY
I
G
---
S
MHKGS
D
-
G
A
V
GT
PA
F
TE
G
-
Y
W
V
A
DA
KL
G
Y
R
V
N
R
----
N
L
D
F
QLNV
Y
NLFD
TD
YVAS
INK
S
G
Y
-------
RYHP
G
E
PR
T
F
LL
TA
N
MH
F
fig|585397.7.peg.778
Escherichia coli ED1a (5-760/760)
RNFPARQFHSL
----
TF
F
AG
LCI
G
ITPV
AQA
L
AAE
GQA
NAD
DTL
V
VEAS
T
PSL
Y
APQQSA
----
----------
DP
K
FSR
P
VA
D
T
TRT
MTV
I
S
E
Q
V
I
K
DQ
G
AT
NL
T
D
AL
K
N
V
PGV
G
AFF
A
G
EN
G
N
S
T
T
G
D
A
I
Y
M
-
RG
AD
TSNS
I
--
-
-
YIDGI
RD
-------
I
GS
----
V
SR
D
TFNT
E
Q
VEVI
K
GP
S
G
TD
YG
R
SAP
T
G
S
INM
I
SK
Q
P
R
N
DSG
I
-
D
A
SA
SI
GS
AWFR
R
GTL
D
VNQV
I
G
D
TT
AV
R
L
N
V
M
G
-E
K
T
H
DA
GR
D
KVKN
ERY
GV
AP
SVA
F
G
LG
TANR
L
YLN
----------
Y
L
HVT
QH
NTP
D
GGI
PT
I
G
LP
G
YS
A
P
SA
GT
AALN
--
H
SGK
V
D
THNFYGT
D
S
DY
D
D
SIT
D
TAT
MR
--------
FEH
D
I
ND
N
A
T
I
R
N
T
T
RWS
R
VK
Q
D
Y
LM
TA
I
M
G
G
A
S
NITQ
P
TSDVN
S
W-
--------
-----------TWS
R
TANTK
D
VSN
K
I
L
TN
QT
N
L
T
S
T
F
Y
TG
A
I
G
H
D
L
S
---------------
TGV
E
F
T
R
--
-
ETQ
T
N
--------------------
Y
G
VN
---
P
VTL
P
AV
N
IYH
PD
-
--------S
S
IH
P
GGLTRNGA
N
ANG
QT
DTFA
I
YA
F
D
TL
Q
ITRD
F
E
L
N
GG
I
R
LD
N
Y
HTE
YD
S
AT
A
CGGSGRGAITCP
AGVAKGSPV
T
T
VDT
--
AKSG
N
LV
N
W
K
AG
AL
Y
H
L
T
E
NG
-
N
V
Y
I
N
YA
V
S
Q
Q
-----
P
PGGNNFALA
Q
S
GSG
---
N
S
A
N
RT
D
F
K
P
Q
K
A
N
T
S
EIG
T
K
WQVL
D
K
RL
LL
T
A
ALFR
TDIE
N
EVE
--------
Q
N
D
D
GTY
SQ
Y
--
G
KK
R
V
E
G
Y
EI
S
VA
---
G
N
IT
P
AWQ
M
I
GGYT
QQK
A
-
----
T
IK
NG
K
DV
AQ
DGSSSLPY
T
PEH
AFT
LWS
Q
Y
QAT
D
-
-
--
D
IS
VG
A
G
A
RY
I
G
---
S
MHKGS
D
-
G
A
V
GT
PA
F
TE
G
-
Y
W
V
A
DA
KL
G
Y
R
V
N
R
----
N
L
D
F
QLNV
Y
NLFD
TD
YVAS
INK
S
G
Y
-------
RYHP
G
E
PR
T
F
LL
TA
N
MH
F
fig|585397.9.peg.778
Escherichia coli ED1a (5-760/760)
RNFPARQFHSL
----
TF
F
AG
LCI
G
ITPV
AQA
L
AAE
GQA
NAD
DTL
V
VEAS
T
PSL
Y
APQQSA
----
----------
DP
K
FSR
P
VA
D
T
TRT
MTV
I
S
E
Q
V
I
K
DQ
G
AT
NL
T
D
AL
K
N
V
PGV
G
AFF
A
G
EN
G
N
S
T
T
G
D
A
I
Y
M
-
RG
AD
TSNS
I
--
-
-
YIDGI
RD
-------
I
GS
----
V
SR
D
TFNT
E
Q
VEVI
K
GP
S
G
TD
YG
R
SAP
T
G
S
INM
I
SK
Q
P
R
N
DSG
I
-
D
A
SA
SI
GS
AWFR
R
GTL
D
VNQV
I
G
D
TT
AV
R
L
N
V
M
G
-E
K
T
H
DA
GR
D
KVKN
ERY
GV
AP
SVA
F
G
LG
TANR
L
YLN
----------
Y
L
HVT
QH
NTP
D
GGI
PT
I
G
LP
G
YS
A
P
SA
GT
AALN
--
H
SGK
V
D
THNFYGT
D
S
DY
D
D
SIT
D
TAT
MR
--------
FEH
D
I
ND
N
A
T
I
R
N
T
T
RWS
R
VK
Q
D
Y
LM
TA
I
M
G
G
A
S
NITQ
P
TSDVN
S
W-
--------
-----------TWS
R
TANTK
D
VSN
K
I
L
TN
QT
N
L
T
S
T
F
Y
TG
A
I
G
H
D
L
S
---------------
TGV
E
F
T
R
--
-
ETQ
T
N
--------------------
Y
G
VN
---
P
VTL
P
AV
N
IYH
PD
-
--------S
S
IH
P
GGLTRNGA
N
ANG
QT
DTFA
I
YA
F
D
TL
Q
ITRD
F
E
L
N
GG
I
R
LD
N
Y
HTE
YD
S
AT
A
CGGSGRGAITCP
AGVAKGSPV
T
T
VDT
--
AKSG
N
LV
N
W
K
AG
AL
Y
H
L
T
E
NG
-
N
V
Y
I
N
YA
V
S
Q
Q
-----
P
PGGNNFALA
Q
S
GSG
---
N
S
A
N
RT
D
F
K
P
Q
K
A
N
T
S
EIG
T
K
WQVL
D
K
RL
LL
T
A
ALFR
TDIE
N
EVE
--------
Q
N
D
D
GTY
SQ
Y
--
G
KK
R
V
E
G
Y
EI
S
VA
---
G
N
IT
P
AWQ
M
I
GGYT
QQK
A
-
----
T
IK
NG
K
DV
AQ
DGSSSLPY
T
PEH
AFT
LWS
Q
Y
QAT
D
-
-
--
D
IS
VG
A
G
A
RY
I
G
---
S
MHKGS
D
-
G
A
V
GT
PA
F
TE
G
-
Y
W
V
A
DA
KL
G
Y
R
V
N
R
----
N
L
D
F
QLNV
Y
NLFD
TD
YVAS
INK
S
G
Y
-------
RYHP
G
E
PR
T
F
LL
TA
N
MH
F
fig|753642.3.peg.860
Escherichia coli NC101 (5-760/760)
RNFPARQFHSL
----
TF
F
AG
LCI
G
ITPV
AQA
L
AAE
GQA
NAD
DTL
V
VEAS
T
PSL
Y
APQQSA
----
----------
DP
K
FSR
P
VA
D
T
TRT
MTV
I
S
E
Q
V
I
K
DQ
G
AT
NL
T
D
AL
K
N
V
PGV
G
AFF
A
G
EN
G
N
S
T
T
G
D
A
I
Y
M
-
RG
AD
TSNS
I
--
-
-
YIDGI
RD
-------
I
GS
----
V
SR
D
TFNT
E
Q
VEVI
K
GP
S
G
TD
YG
R
SAP
T
G
S
INM
I
SK
Q
P
R
N
DSG
I
-
D
A
SA
SI
GS
AWFR
R
GTL
D
VNQV
I
G
D
TT
AV
R
L
N
V
M
G
-E
K
T
H
DA
GR
D
KVKN
ERY
GV
AP
SVA
F
G
LG
TANR
L
YLN
----------
Y
L
HVT
QH
NTP
D
GGI
PT
I
G
LP
G
YS
A
P
SA
GT
AALN
--
H
SGK
V
D
THNFYGT
D
S
DY
D
D
SIT
D
TAT
MR
--------
FEH
D
I
ND
N
A
T
I
R
N
T
T
RWS
R
VK
Q
D
Y
LM
TA
I
M
G
G
A
S
NITQ
P
TSDVN
S
W-
--------
-----------TWS
R
TANTK
D
VSN
K
I
L
TN
QT
N
L
T
S
T
F
Y
TG
A
I
G
H
D
L
S
---------------
TGV
E
F
T
R
--
-
ETQ
T
N
--------------------
Y
G
VN
---
P
VTL
P
AV
N
IYH
PD
-
--------S
S
IH
P
GGLTRNGA
N
ANG
QT
DTFA
I
YA
F
D
TL
Q
ITRD
F
E
L
N
GG
I
R
LD
N
Y
HTE
YD
S
AT
A
CGGSGRGAITCP
AGVAKGSPV
T
T
VDT
--
AKSG
N
LV
N
W
K
AG
AL
Y
H
L
T
E
NG
-
N
V
Y
I
N
YA
V
S
Q
Q
-----
P
PGGNNFALA
Q
S
GSG
---
N
S
A
N
RT
D
F
K
P
Q
K
A
N
T
S
EIG
T
K
WQVL
D
K
RL
LL
T
A
ALFR
TDIE
N
EVE
--------
Q
N
D
D
GTY
SQ
Y
--
G
KK
R
V
E
G
Y
EI
S
VA
---
G
N
IT
P
AWQ
M
I
GGYT
QQK
A
-
----
T
IK
NG
K
DV
AQ
DGSSSLPY
T
PEH
AFT
LWS
Q
Y
QAT
D
-
-
--
D
IS
VG
A
G
A
RY
I
G
---
S
MHKGS
D
-
G
A
V
GT
PA
F
TE
G
-
Y
W
V
A
DA
KL
G
Y
R
V
N
R
----
N
L
D
F
QLNV
Y
NLFD
TD
YVAS
INK
S
G
Y
-------
RYHP
G
E
PR
T
F
LL
TA
N
MH
F
fig|585034.4.peg.829
Escherichia coli IAI1 (5-760/760)
RNFPARQFHSL
----
TF
F
AG
LCI
G
ITPV
AQA
L
AAE
GQT
NAD
DTL
V
VEAS
T
PSL
Y
APQQSA
----
----------
DP
K
FSR
P
VA
D
T
TRT
MTV
I
S
E
Q
V
I
K
DQ
G
AT
NL
T
D
AL
K
N
V
PGV
G
AFF
A
G
EN
G
N
S
T
T
G
D
A
I
Y
M
-
RG
AD
TSNS
I
--
-
-
YIDGI
RD
-------
I
GS
----
V
SR
D
TFNT
E
Q
VEVI
K
GP
S
G
TD
YG
R
SAP
T
G
S
INM
I
SK
Q
P
R
N
DSG
I
-
D
A
SA
SI
GS
AWFR
R
GTL
D
VNQV
I
G
D
TT
AV
R
L
N
V
M
G
-E
K
T
H
DA
GR
D
KVKN
ERY
GV
AP
SIA
F
G
LG
TANR
L
YLN
----------
Y
L
HVT
QH
NTP
D
GGI
PT
I
G
LP
G
YS
A
P
SA
GT
AALN
--
H
SGK
V
D
THNFYGT
D
S
DY
D
D
STT
D
TAT
MR
--------
FEH
D
I
ND
N
T
T
I
R
N
T
T
RWS
R
VK
Q
D
Y
LM
TA
I
M
G
G
A
S
NITQ
P
TSDVN
S
W-
--------
-----------TWS
R
TANTK
D
VSN
K
I
L
TN
QT
N
L
T
S
T
F
Y
TG
S
I
G
H
D
V
S
---------------
TGV
E
F
T
R
--
-
ETQ
T
N
--------------------
Y
G
VN
---
P
VTL
P
AV
N
IYH
PD
-
--------S
S
IH
P
GGLTRNGA
N
ANG
QT
DTFA
I
YA
F
D
TL
Q
ITRD
F
E
L
N
GG
I
R
LD
N
Y
HTE
YD
S
AT
A
CGGSGRGAITCP
AGVAKGSPV
T
T
VDT
--
AKSG
N
LV
N
W
K
AG
AL
Y
H
L
T
E
NG
-
N
V
Y
I
N
YA
V
S
Q
Q
-----
P
PGGNNFALA
Q
S
GSG
---
N
S
A
N
RT
D
F
K
P
Q
K
A
N
T
S
EIG
T
K
WQVL
D
K
RL
LL
T
A
ALFR
TDIE
N
EVE
--------
Q
N
D
D
GTY
SQ
Y
--
G
KK
R
V
E
G
Y
EI
S
VA
---
G
N
IT
P
AW
L
V
I
GGYT
QQK
A
-
----
T
IK
NG
K
DV
AQ
DGSSSLPY
T
PEH
AFT
LWS
Q
Y
QAT
D
-
-
--
D
IS
VG
A
G
A
RY
I
G
---
S
MHKGS
D
-
G
A
V
GT
PA
F
TE
G
-
Y
W
V
A
DA
KL
G
Y
R
V
N
R
----
N
L
D
F
QLNV
Y
NLFD
TD
YVAS
INK
S
G
Y
-------
RYHP
G
E
PR
T
F
LL
TA
N
MH
F
fig|585034.5.peg.825
Escherichia coli IAI1 (5-760/760)
RNFPARQFHSL
----
TF
F
AG
LCI
G
ITPV
AQA
L
AAE
GQT
NAD
DTL
V
VEAS
T
PSL
Y
APQQSA
----
----------
DP
K
FSR
P
VA
D
T
TRT
MTV
I
S
E
Q
V
I
K
DQ
G
AT
NL
T
D
AL
K
N
V
PGV
G
AFF
A
G
EN
G
N
S
T
T
G
D
A
I
Y
M
-
RG
AD
TSNS
I
--
-
-
YIDGI
RD
-------
I
GS
----
V
SR
D
TFNT
E
Q
VEVI
K
GP
S
G
TD
YG
R
SAP
T
G
S
INM
I
SK
Q
P
R
N
DSG
I
-
D
A
SA
SI
GS
AWFR
R
GTL
D
VNQV
I
G
D
TT
AV
R
L
N
V
M
G
-E
K
T
H
DA
GR
D
KVKN
ERY
GV
AP
SIA
F
G
LG
TANR
L
YLN
----------
Y
L
HVT
QH
NTP
D
GGI
PT
I
G
LP
G
YS
A
P
SA
GT
AALN
--
H
SGK
V
D
THNFYGT
D
S
DY
D
D
STT
D
TAT
MR
--------
FEH
D
I
ND
N
T
T
I
R
N
T
T
RWS
R
VK
Q
D
Y
LM
TA
I
M
G
G
A
S
NITQ
P
TSDVN
S
W-
--------
-----------TWS
R
TANTK
D
VSN
K
I
L
TN
QT
N
L
T
S
T
F
Y
TG
S
I
G
H
D
V
S
---------------
TGV
E
F
T
R
--
-
ETQ
T
N
--------------------
Y
G
VN
---
P
VTL
P
AV
N
IYH
PD
-
--------S
S
IH
P
GGLTRNGA
N
ANG
QT
DTFA
I
YA
F
D
TL
Q
ITRD
F
E
L
N
GG
I
R
LD
N
Y
HTE
YD
S
AT
A
CGGSGRGAITCP
AGVAKGSPV
T
T
VDT
--
AKSG
N
LV
N
W
K
AG
AL
Y
H
L
T
E
NG
-
N
V
Y
I
N
YA
V
S
Q
Q
-----
P
PGGNNFALA
Q
S
GSG
---
N
S
A
N
RT
D
F
K
P
Q
K
A
N
T
S
EIG
T
K
WQVL
D
K
RL
LL
T
A
ALFR
TDIE
N
EVE
--------
Q
N
D
D
GTY
SQ
Y
--
G
KK
R
V
E
G
Y
EI
S
VA
---
G
N
IT
P
AW
L
V
I
GGYT
QQK
A
-
----
T
IK
NG
K
DV
AQ
DGSSSLPY
T
PEH
AFT
LWS
Q
Y
QAT
D
-
-
--
D
IS
VG
A
G
A
RY
I
G
---
S
MHKGS
D
-
G
A
V
GT
PA
F
TE
G
-
Y
W
V
A
DA
KL
G
Y
R
V
N
R
----
N
L
D
F
QLNV
Y
NLFD
TD
YVAS
INK
S
G
Y
-------
RYHP
G
E
PR
T
F
LL
TA
N
MH
F
fig|405955.13.peg.764
Escherichia coli APEC O1 (5-760/760)
RNFPARQFHSL
----
TF
F
AG
LCI
G
ITPV
AQA
L
AAE
GQA
NAD
DTL
V
VEAS
T
PSL
Y
APQQSA
----
----------
DP
K
FSR
P
VA
D
T
TRT
MTV
I
S
E
Q
V
I
K
DQ
G
AT
NL
T
D
AL
K
N
V
PGV
G
AFF
A
G
EN
G
N
S
T
T
G
D
A
I
Y
M
-
RG
AD
TSNS
I
--
-
-
YIDGI
RD
-------
I
GS
----
V
SR
D
TFNT
E
Q
VEVI
K
GP
S
G
TD
YG
R
SAP
T
G
S
INM
I
SK
Q
P
R
N
DSG
I
-
D
A
SA
SI
GS
AWFR
R
GTL
D
VNQV
I
G
D
TT
AV
R
L
N
V
M
G
-E
K
T
H
DA
GR
D
KVKN
ERY
GV
AP
SVA
F
G
LG
TANR
L
YLN
----------
Y
L
HVT
QH
NTP
D
GGI
PT
I
G
LP
G
YS
A
P
SA
GT
AALN
--
H
SGK
V
D
THNFYGT
D
S
DY
D
D
STT
D
TAT
MR
--------
FEH
D
I
ND
N
T
T
I
R
N
T
T
RWS
R
VK
Q
D
Y
LM
TA
I
M
G
G
A
S
NITQ
P
TSDVN
S
W-
--------
-----------TWS
R
TANTK
D
VSN
K
I
L
TN
QT
N
L
T
S
T
F
Y
TG
A
I
G
H
D
V
S
---------------
TGV
E
F
T
R
--
-
ETQ
T
N
--------------------
Y
G
VN
---
P
VTL
P
AV
N
IYH
PD
-
--------S
S
IH
P
SGLTRNGA
N
ANG
QT
DTFA
I
YA
F
D
TL
Q
ITRD
F
E
L
N
GG
I
R
LD
N
Y
HTE
YD
S
AT
A
CGGSGRGAITCP
AGVAKGSPV
T
T
VDT
--
AKSG
N
LV
N
W
K
AG
AL
Y
H
L
T
E
NG
-
N
I
Y
I
N
YA
V
S
Q
Q
-----
P
PGGNNFALA
Q
S
GSG
---
N
S
A
N
RT
D
F
K
P
Q
K
A
N
T
S
EIG
T
K
WQVL
D
K
RL
LL
T
A
ALFR
TDIE
N
EVE
--------
Q
N
D
D
GTY
SQ
Y
--
G
KK
R
V
E
G
Y
EI
S
VA
---
G
N
IT
P
AWQ
M
I
GGYT
QQK
A
-
----
T
IK
NG
K
DV
AQ
DGSSSLPY
T
PEH
AFT
LWS
Q
Y
QAT
D
-
-
--
D
IS
VG
A
G
A
RY
I
G
---
S
MHKGS
D
-
G
A
V
GT
PA
F
TE
G
-
Y
W
V
A
DA
KL
G
Y
R
V
N
R
----
N
L
D
F
QLNV
Y
NLFD
TD
YVAS
INK
S
G
Y
-------
RYHP
G
E
PR
T
F
LL
TA
N
MH
F
fig|405955.9.peg.640
Escherichia coli APEC O1 (5-760/760)
RNFPARQFHSL
----
TF
F
AG
LCI
G
ITPV
AQA
L
AAE
GQA
NAD
DTL
V
VEAS
T
PSL
Y
APQQSA
----
----------
DP
K
FSR
P
VA
D
T
TRT
MTV
I
S
E
Q
V
I
K
DQ
G
AT
NL
T
D
AL
K
N
V
PGV
G
AFF
A
G
EN
G
N
S
T
T
G
D
A
I
Y
M
-
RG
AD
TSNS
I
--
-
-
YIDGI
RD
-------
I
GS
----
V
SR
D
TFNT
E
Q
VEVI
K
GP
S
G
TD
YG
R
SAP
T
G
S
INM
I
SK
Q
P
R
N
DSG
I
-
D
A
SA
SI
GS
AWFR
R
GTL
D
VNQV
I
G
D
TT
AV
R
L
N
V
M
G
-E
K
T
H
DA
GR
D
KVKN
ERY
GV
AP
SVA
F
G
LG
TANR
L
YLN
----------
Y
L
HVT
QH
NTP
D
GGI
PT
I
G
LP
G
YS
A
P
SA
GT
AALN
--
H
SGK
V
D
THNFYGT
D
S
DY
D
D
STT
D
TAT
MR
--------
FEH
D
I
ND
N
T
T
I
R
N
T
T
RWS
R
VK
Q
D
Y
LM
TA
I
M
G
G
A
S
NITQ
P
TSDVN
S
W-
--------
-----------TWS
R
TANTK
D
VSN
K
I
L
TN
QT
N
L
T
S
T
F
Y
TG
A
I
G
H
D
V
S
---------------
TGV
E
F
T
R
--
-
ETQ
T
N
--------------------
Y
G
VN
---
P
VTL
P
AV
N
IYH
PD
-
--------S
S
IH
P
SGLTRNGA
N
ANG
QT
DTFA
I
YA
F
D
TL
Q
ITRD
F
E
L
N
GG
I
R
LD
N
Y
HTE
YD
S
AT
A
CGGSGRGAITCP
AGVAKGSPV
T
T
VDT
--
AKSG
N
LV
N
W
K
AG
AL
Y
H
L
T
E
NG
-
N
I
Y
I
N
YA
V
S
Q
Q
-----
P
PGGNNFALA
Q
S
GSG
---
N
S
A
N
RT
D
F
K
P
Q
K
A
N
T
S
EIG
T
K
WQVL
D
K
RL
LL
T
A
ALFR
TDIE
N
EVE
--------
Q
N
D
D
GTY
SQ
Y
--
G
KK
R
V
E
G
Y
EI
S
VA
---
G
N
IT
P
AWQ
M
I
GGYT
QQK
A
-
----
T
IK
NG
K
DV
AQ
DGSSSLPY
T
PEH
AFT
LWS
Q
Y
QAT
D
-
-
--
D
IS
VG
A
G
A
RY
I
G
---
S
MHKGS
D
-
G
A
V
GT
PA
F
TE
G
-
Y
W
V
A
DA
KL
G
Y
R
V
N
R
----
N
L
D
F
QLNV
Y
NLFD
TD
YVAS
INK
S
G
Y
-------
RYHP
G
E
PR
T
F
LL
TA
N
MH
F
fig|199310.1.peg.863
Escherichia coli CFT073 (5-760/760)
RNFPARQFHSL
----
TF
F
AG
LCI
G
ITPV
AQA
L
AAE
GQA
NAD
DTL
V
VEAS
T
PSL
Y
APQQSA
----
----------
DP
K
FSR
P
VA
D
T
TRT
MTV
I
S
E
Q
V
I
K
DQ
G
AT
NL
T
D
AL
K
N
V
PGV
G
AFF
A
G
EN
G
N
S
T
T
G
D
A
I
Y
M
-
RG
AD
TSNS
I
--
-
-
YIDGI
RD
-------
I
GS
----
V
SR
D
TFNT
E
Q
VEVI
K
GP
S
G
TD
YG
R
SAP
T
G
S
INM
I
SK
Q
P
R
N
DSG
I
-
D
A
SA
SI
GS
AWFR
R
GTL
D
VNQV
I
G
D
TT
AV
R
L
N
V
M
G
-E
K
T
H
DA
GR
D
KVKN
ERY
GV
AP
SVV
F
G
LG
TANR
L
YLN
----------
Y
L
HVT
QH
NTP
D
GGI
PT
I
G
LP
G
YS
A
P
SA
GT
AALN
--
H
SGK
V
D
THNFYGT
D
S
DY
D
D
STT
D
TAT
MR
--------
FEH
D
I
ND
N
T
T
I
R
N
T
T
RWS
R
VK
Q
D
Y
LM
TA
I
M
G
G
A
S
NITQ
P
TSDVN
S
W-
--------
-----------TWS
R
TANTK
D
VSN
K
I
L
TN
QT
N
L
T
S
T
F
Y
TG
A
I
G
H
D
L
S
---------------
TGV
E
F
T
R
--
-
ETQ
T
N
--------------------
Y
G
VN
---
P
VTL
P
AV
N
IYH
PD
-
--------S
S
IH
P
GGLTRNGA
N
ANG
QT
DTFA
I
YA
F
D
TL
Q
ITRD
F
E
L
N
GG
I
R
LD
N
Y
HTE
YD
S
AT
A
CGGSGRGAITCP
AGVAKGSPV
T
T
VDT
--
AKSG
N
LV
N
W
K
AG
AL
Y
H
L
T
E
NG
-
N
V
Y
I
N
YA
V
S
Q
Q
-----
P
PGGNNFALA
Q
S
GSG
---
N
S
A
N
RT
D
F
K
P
Q
K
A
N
T
S
EIG
T
K
WQVL
D
K
RL
LL
T
A
ALFR
TDIE
N
EVE
--------
Q
N
D
D
GTY
SQ
Y
--
G
KK
R
V
E
G
Y
EI
S
VA
---
G
N
IT
P
AWQ
M
I
GGYT
QQK
A
-
----
T
IK
NG
K
DV
AQ
DGSSSLPY
T
PEH
AFT
LWS
Q
Y
QAT
D
-
-
--
D
IS
VG
A
G
A
RY
I
G
---
S
MHKGS
D
-
G
A
V
GT
PA
F
TE
G
-
Y
W
V
A
DA
KL
G
Y
R
V
N
R
----
N
L
D
F
QLNV
Y
NLFD
TD
YVAS
INK
S
G
Y
-------
RYHP
G
E
PR
T
F
LL
TA
N
MH
F
fig|199310.4.peg.844
Escherichia coli CFT073 (5-760/760)
RNFPARQFHSL
----
TF
F
AG
LCI
G
ITPV
AQA
L
AAE
GQA
NAD
DTL
V
VEAS
T
PSL
Y
APQQSA
----
----------
DP
K
FSR
P
VA
D
T
TRT
MTV
I
S
E
Q
V
I
K
DQ
G
AT
NL
T
D
AL
K
N
V
PGV
G
AFF
A
G
EN
G
N
S
T
T
G
D
A
I
Y
M
-
RG
AD
TSNS
I
--
-
-
YIDGI
RD
-------
I
GS
----
V
SR
D
TFNT
E
Q
VEVI
K
GP
S
G
TD
YG
R
SAP
T
G
S
INM
I
SK
Q
P
R
N
DSG
I
-
D
A
SA
SI
GS
AWFR
R
GTL
D
VNQV
I
G
D
TT
AV
R
L
N
V
M
G
-E
K
T
H
DA
GR
D
KVKN
ERY
GV
AP
SVV
F
G
LG
TANR
L
YLN
----------
Y
L
HVT
QH
NTP
D
GGI
PT
I
G
LP
G
YS
A
P
SA
GT
AALN
--
H
SGK
V
D
THNFYGT
D
S
DY
D
D
STT
D
TAT
MR
--------
FEH
D
I
ND
N
T
T
I
R
N
T
T
RWS
R
VK
Q
D
Y
LM
TA
I
M
G
G
A
S
NITQ
P
TSDVN
S
W-
--------
-----------TWS
R
TANTK
D
VSN
K
I
L
TN
QT
N
L
T
S
T
F
Y
TG
A
I
G
H
D
L
S
---------------
TGV
E
F
T
R
--
-
ETQ
T
N
--------------------
Y
G
VN
---
P
VTL
P
AV
N
IYH
PD
-
--------S
S
IH
P
GGLTRNGA
N
ANG
QT
DTFA
I
YA
F
D
TL
Q
ITRD
F
E
L
N
GG
I
R
LD
N
Y
HTE
YD
S
AT
A
CGGSGRGAITCP
AGVAKGSPV
T
T
VDT
--
AKSG
N
LV
N
W
K
AG
AL
Y
H
L
T
E
NG
-
N
V
Y
I
N
YA
V
S
Q
Q
-----
P
PGGNNFALA
Q
S
GSG
---
N
S
A
N
RT
D
F
K
P
Q
K
A
N
T
S
EIG
T
K
WQVL
D
K
RL
LL
T
A
ALFR
TDIE
N
EVE
--------
Q
N
D
D
GTY
SQ
Y
--
G
KK
R
V
E
G
Y
EI
S
VA
---
G
N
IT
P
AWQ
M
I
GGYT
QQK
A
-
----
T
IK
NG
K
DV
AQ
DGSSSLPY
T
PEH
AFT
LWS
Q
Y
QAT
D
-
-
--
D
IS
VG
A
G
A
RY
I
G
---
S
MHKGS
D
-
G
A
V
GT
PA
F
TE
G
-
Y
W
V
A
DA
KL
G
Y
R
V
N
R
----
N
L
D
F
QLNV
Y
NLFD
TD
YVAS
INK
S
G
Y
-------
RYHP
G
E
PR
T
F
LL
TA
N
MH
F
fig|714962.3.peg.812
Escherichia coli IHE3034 (5-760/760)
RNFPARQFHSL
----
TF
F
AG
LCI
G
ITPV
AQA
L
AAE
GQA
NAD
DTL
V
VEAS
T
PSL
Y
APQQSA
----
----------
DP
K
FSR
P
VA
D
T
TRT
MTV
I
S
E
Q
V
I
K
DQ
G
AT
NL
T
D
AL
K
N
V
PGV
G
AFF
A
G
EN
G
N
S
T
T
G
D
A
I
Y
M
-
RG
AD
TSNS
I
--
-
-
YIDGI
RD
-------
I
GS
----
V
SR
D
TFNT
E
Q
VEVI
K
GP
S
G
TD
YG
R
SAP
T
G
S
INM
I
SK
Q
P
R
N
DSG
I
-
D
A
SA
SI
GS
AWFR
R
GTL
D
VNQV
I
G
D
TT
AV
R
L
N
V
M
G
-E
K
T
H
DA
GR
D
KVKN
ERY
GV
AP
SVA
F
G
LG
TANR
L
YLN
----------
Y
L
HVT
QH
NTP
D
GGI
PT
I
G
LP
G
YS
A
P
SA
GT
AALN
--
H
SGK
V
D
THNFYGT
D
S
DY
D
D
STT
D
TAT
MR
--------
FEH
D
I
ND
N
T
T
I
R
N
T
T
RWS
R
VK
Q
D
Y
LM
TA
I
M
G
G
A
S
NITQ
P
TSDVN
S
W-
--------
-----------TWS
R
TANTK
D
VSN
K
I
L
TN
QT
N
L
T
S
T
F
Y
TG
A
I
G
H
D
V
S
---------------
TGV
E
F
T
R
--
-
ETQ
T
N
--------------------
Y
G
VN
---
P
VTL
P
AV
N
IYH
PD
-
--------S
S
IH
P
GGLTRNGA
N
ANG
QT
DTFA
I
YA
F
D
TL
Q
ITRD
F
E
L
N
GG
I
R
LD
N
Y
HTE
YD
S
AT
A
CGGSGRGAITCP
AGVAKGSPV
T
T
VDT
--
AKSG
N
LV
N
W
K
AG
AL
Y
H
L
T
E
NG
-
N
I
Y
I
N
YA
V
S
Q
Q
-----
P
PGGNNFALA
Q
S
GSG
---
N
S
A
N
RT
D
F
K
P
Q
K
A
N
T
S
EIG
T
K
WQVL
D
K
RL
LL
T
A
ALFR
TDIE
N
EVE
--------
Q
N
D
D
GTY
SQ
Y
--
G
KK
R
V
E
G
Y
EI
S
VA
---
G
N
IT
P
AWQ
M
I
GGYT
QQK
A
-
----
T
IK
NG
K
DV
AQ
DGSSSLPY
T
PEH
AFT
LWS
Q
Y
QAT
D
-
-
--
D
IS
VG
A
G
A
RY
I
G
---
S
MHKGS
D
-
G
A
V
GT
PA
F
TE
G
-
Y
W
V
A
DA
KL
G
Y
R
V
N
R
----
N
L
D
F
QLNV
Y
NLFD
TD
YVAS
INK
S
G
Y
-------
RYHP
G
E
PR
T
F
LL
TA
N
MH
F
fig|869729.3.peg.2908
Escherichia coli UM146 (5-760/760)
RNFPARQFHSL
----
TF
F
AG
LCI
G
ITPV
AQA
L
AAE
GQA
NAD
DTL
V
VEAS
T
PSL
Y
APQQSA
----
----------
DP
K
FSR
P
VA
D
T
TRT
MTV
I
S
E
Q
V
I
K
DQ
G
AT
NL
T
D
AL
K
N
V
PGV
G
AFF
A
G
EN
G
N
S
T
T
G
D
A
I
Y
M
-
RG
AD
TSNS
I
--
-
-
YIDGI
RD
-------
I
GS
----
V
SR
D
TFNT
E
Q
VEVI
K
GP
S
G
TD
YG
R
SAP
T
G
S
INM
I
SK
Q
P
R
N
DSG
I
-
D
A
SA
SI
GS
AWFR
R
GTL
D
VNQV
I
G
D
TT
AV
R
L
N
V
M
G
-E
K
T
H
DA
GR
D
KVKN
ERY
GV
AP
SVA
F
G
LG
TANR
L
YLN
----------
Y
L
HVT
QH
NTP
D
GGI
PT
I
G
LP
G
YS
A
P
SA
GT
AALN
--
H
SGK
V
D
THNFYGT
D
S
DY
D
D
STT
D
TAT
MR
--------
FEH
D
I
ND
N
T
T
I
R
N
T
T
RWS
R
VK
Q
D
Y
LM
TA
I
M
G
G
A
S
NITQ
P
TSDVN
S
W-
--------
-----------TWS
R
TANTK
D
VSN
K
I
L
TN
QT
N
L
T
S
T
F
Y
TG
A
I
G
H
D
V
S
---------------
TGV
E
F
T
R
--
-
ETQ
T
N
--------------------
Y
G
VN
---
P
VTL
P
AV
N
IYH
PD
-
--------S
S
IH
P
GGLTRNGA
N
ANG
QT
DTFA
I
YA
F
D
TL
Q
ITRD
F
E
L
N
GG
I
R
LD
N
Y
HTE
YD
S
AT
A
CGGSGRGAITCP
AGVAKGSPV
T
T
VDT
--
AKSG
N
LV
N
W
K
AG
AL
Y
H
L
T
E
NG
-
N
I
Y
I
N
YA
V
S
Q
Q
-----
P
PGGNNFALA
Q
S
GSG
---
N
S
A
N
RT
D
F
K
P
Q
K
A
N
T
S
EIG
T
K
WQVL
D
K
RL
LL
T
A
ALFR
TDIE
N
EVE
--------
Q
N
D
D
GTY
SQ
Y
--
G
KK
R
V
E
G
Y
EI
S
VA
---
G
N
IT
P
AWQ
M
I
GGYT
QQK
A
-
----
T
IK
NG
K
DV
AQ
DGSSSLPY
T
PEH
AFT
LWS
Q
Y
QAT
D
-
-
--
D
IS
VG
A
G
A
RY
I
G
---
S
MHKGS
D
-
G
A
V
GT
PA
F
TE
G
-
Y
W
V
A
DA
KL
G
Y
R
V
N
R
----
N
L
D
F
QLNV
Y
NLFD
TD
YVAS
INK
S
G
Y
-------
RYHP
G
E
PR
T
F
LL
TA
N
MH
F
fig|364106.7.peg.893
Escherichia coli UTI89 (5-760/760)
RNFPARQFHSL
----
TF
F
AG
LCI
G
ITPV
AQA
L
AAE
GQA
NAD
DTL
V
VEAS
T
PSL
Y
APQQSA
----
----------
DP
K
FSR
P
VA
D
T
TRT
MTV
I
S
E
Q
V
I
K
DQ
G
AT
NL
T
D
AL
K
N
V
PGV
G
AFF
A
G
EN
G
N
S
T
T
G
D
A
I
Y
M
-
RG
AD
TSNS
I
--
-
-
YIDGI
RD
-------
I
GS
----
V
SR
D
TFNT
E
Q
VEVI
K
GP
S
G
TD
YG
R
SAP
T
G
S
INM
I
SK
Q
P
R
N
DSG
I
-
D
A
SA
SI
GS
AWFR
R
GTL
D
VNQV
I
G
D
TT
AV
R
L
N
V
M
G
-E
K
T
H
DA
GR
D
KVKN
ERY
GV
AP
SVA
F
G
LG
TANR
L
YLN
----------
Y
L
HVT
QH
NTP
D
GGI
PT
I
G
LP
G
YS
A
P
SA
GT
AALN
--
H
SGK
V
D
THNFYGT
D
S
DY
D
D
STT
D
TAT
MR
--------
FEH
D
I
ND
N
T
T
I
R
N
T
T
RWS
R
VK
Q
D
Y
LM
TA
I
M
G
G
A
S
NITQ
P
TSDVN
S
W-
--------
-----------TWS
R
TANTK
D
VSN
K
I
L
TN
QT
N
L
T
S
T
F
Y
TG
A
I
G
H
D
V
S
---------------
TGV
E
F
T
R
--
-
ETQ
T
N
--------------------
Y
G
VN
---
P
VTL
P
AV
N
IYH
PD
-
--------S
S
IH
P
GGLTRNGA
N
ANG
QT
DTFA
I
YA
F
D
TL
Q
ITRD
F
E
L
N
GG
I
R
LD
N
Y
HTE
YD
S
AT
A
CGGSGRGAITCP
AGVAKGSPV
T
T
VDT
--
AKSG
N
LV
N
W
K
AG
AL
Y
H
L
T
E
NG
-
N
I
Y
I
N
YA
V
S
Q
Q
-----
P
PGGNNFALA
Q
S
GSG
---
N
S
A
N
RT
D
F
K
P
Q
K
A
N
T
S
EIG
T
K
WQVL
D
K
RL
LL
T
A
ALFR
TDIE
N
EVE
--------
Q
N
D
D
GTY
SQ
Y
--
G
KK
R
V
E
G
Y
EI
S
VA
---
G
N
IT
P
AWQ
M
I
GGYT
QQK
A
-
----
T
IK
NG
K
DV
AQ
DGSSSLPY
T
PEH
AFT
LWS
Q
Y
QAT
D
-
-
--
D
IS
VG
A
G
A
RY
I
G
---
S
MHKGS
D
-
G
A
V
GT
PA
F
TE
G
-
Y
W
V
A
DA
KL
G
Y
R
V
N
R
----
N
L
D
F
QLNV
Y
NLFD
TD
YVAS
INK
S
G
Y
-------
RYHP
G
E
PR
T
F
LL
TA
N
MH
F
fig|364106.8.peg.892
Escherichia coli UTI89 (5-760/760)
RNFPARQFHSL
----
TF
F
AG
LCI
G
ITPV
AQA
L
AAE
GQA
NAD
DTL
V
VEAS
T
PSL
Y
APQQSA
----
----------
DP
K
FSR
P
VA
D
T
TRT
MTV
I
S
E
Q
V
I
K
DQ
G
AT
NL
T
D
AL
K
N
V
PGV
G
AFF
A
G
EN
G
N
S
T
T
G
D
A
I
Y
M
-
RG
AD
TSNS
I
--
-
-
YIDGI
RD
-------
I
GS
----
V
SR
D
TFNT
E
Q
VEVI
K
GP
S
G
TD
YG
R
SAP
T
G
S
INM
I
SK
Q
P
R
N
DSG
I
-
D
A
SA
SI
GS
AWFR
R
GTL
D
VNQV
I
G
D
TT
AV
R
L
N
V
M
G
-E
K
T
H
DA
GR
D
KVKN
ERY
GV
AP
SVA
F
G
LG
TANR
L
YLN
----------
Y
L
HVT
QH
NTP
D
GGI
PT
I
G
LP
G
YS
A
P
SA
GT
AALN
--
H
SGK
V
D
THNFYGT
D
S
DY
D
D
STT
D
TAT
MR
--------
FEH
D
I
ND
N
T
T
I
R
N
T
T
RWS
R
VK
Q
D
Y
LM
TA
I
M
G
G
A
S
NITQ
P
TSDVN
S
W-
--------
-----------TWS
R
TANTK
D
VSN
K
I
L
TN
QT
N
L
T
S
T
F
Y
TG
A
I
G
H
D
V
S
---------------
TGV
E
F
T
R
--
-
ETQ
T
N
--------------------
Y
G
VN
---
P
VTL
P
AV
N
IYH
PD
-
--------S
S
IH
P
GGLTRNGA
N
ANG
QT
DTFA
I
YA
F
D
TL
Q
ITRD
F
E
L
N
GG
I
R
LD
N
Y
HTE
YD
S
AT
A
CGGSGRGAITCP
AGVAKGSPV
T
T
VDT
--
AKSG
N
LV
N
W
K
AG
AL
Y
H
L
T
E
NG
-
N
I
Y
I
N
YA
V
S
Q
Q
-----
P
PGGNNFALA
Q
S
GSG
---
N
S
A
N
RT
D
F
K
P
Q
K
A
N
T
S
EIG
T
K
WQVL
D
K
RL
LL
T
A
ALFR
TDIE
N
EVE
--------
Q
N
D
D
GTY
SQ
Y
--
G
KK
R
V
E
G
Y
EI
S
VA
---
G
N
IT
P
AWQ
M
I
GGYT
QQK
A
-
----
T
IK
NG
K
DV
AQ
DGSSSLPY
T
PEH
AFT
LWS
Q
Y
QAT
D
-
-
--
D
IS
VG
A
G
A
RY
I
G
---
S
MHKGS
D
-
G
A
V
GT
PA
F
TE
G
-
Y
W
V
A
DA
KL
G
Y
R
V
N
R
----
N
L
D
F
QLNV
Y
NLFD
TD
YVAS
INK
S
G
Y
-------
RYHP
G
E
PR
T
F
LL
TA
N
MH
F
fig|562.371.peg.2247
Escherichia coli 1044A (5-760/760)
RNFPARQFHSL
----
TF
F
AG
LCI
G
ITPV
AQA
L
AAE
GQT
NAD
DTL
V
VEAS
T
PSL
Y
APQQSA
----
----------
DP
K
FSR
P
VA
D
T
TRT
MTV
I
S
E
Q
V
I
K
DQ
G
AT
NL
T
D
AL
K
N
V
PGV
G
AFF
A
G
EN
G
N
S
T
T
G
D
A
I
Y
M
-
RG
AD
TSNS
I
--
-
-
YIDGI
RD
-------
I
GS
----
V
SR
D
TFNT
E
Q
VEVI
K
GP
S
G
TD
YG
R
SAP
T
G
S
INM
I
SK
Q
P
R
N
DSG
I
-
D
A
SA
SI
GS
AWFR
R
GTL
D
VNQV
I
G
D
TT
AV
R
L
N
V
M
G
-E
K
T
H
DA
GR
D
KVKN
ERY
GV
AP
SIA
F
G
LG
TANR
L
YLN
----------
Y
L
HVT
QH
NTP
D
GGI
PT
I
G
LP
G
YS
A
P
SA
GT
ATLN
--
H
SGK
V
D
THNFYGT
D
S
DY
D
D
STT
D
TAT
MR
--------
FEH
D
I
ND
N
T
T
I
R
N
T
T
RWS
R
VK
Q
D
Y
LM
TA
I
M
G
G
A
S
NITQ
P
TSDVN
S
W-
--------
-----------TWS
R
TANTK
D
VSN
K
I
L
TN
QT
N
L
T
S
T
F
Y
T
A
S
I
G
H
D
V
S
---------------
TGV
E
F
T
R
--
-
ETQ
T
N
--------------------
Y
G
VN
---
P
VTL
P
AV
N
IYH
PD
-
--------S
S
IH
P
GGLTRNGA
N
ANG
QT
DTFA
I
YA
F
D
TL
Q
ITRD
F
E
L
N
GG
I
R
LD
N
Y
HTE
YD
S
AT
A
CGGSGRGAITCP
AGVAKGSPV
T
T
VDT
--
AKSG
N
LV
N
W
K
AG
AL
Y
H
L
T
E
NG
-
N
V
Y
I
N
YA
V
S
Q
Q
-----
P
PGGNNFALA
Q
S
GSG
---
N
S
A
N
RT
D
F
K
P
Q
K
A
N
T
S
EIG
T
K
WQVL
D
K
RL
LL
T
A
ALFR
TDIE
N
EVE
--------
Q
N
D
D
GTY
SQ
Y
--
G
KK
R
V
E
G
Y
EI
S
VA
---
G
N
IT
P
AWQV
I
GGYT
QQK
A
-
----
T
IK
NG
K
DV
AQ
DGSSSLPY
T
PEH
AFT
LWS
Q
Y
QAT
D
-
-
--
D
IS
VG
A
G
A
RY
I
G
---
S
MHKGS
D
-
G
A
V
GT
PA
F
TE
G
-
Y
W
V
A
DA
KL
G
Y
R
V
N
R
----
N
L
D
F
QLNV
Y
NLFD
TD
YVAS
INK
S
G
Y
-------
RYHP
G
E
PR
T
F
LL
TA
N
MH
F
fig|562.373.peg.1230
Escherichia coli 1125A (5-760/760)
RNFPARQFHSL
----
TF
F
AG
LCI
G
ITPV
AQA
L
AAE
GQT
NAD
DTL
V
VEAS
T
PSL
Y
APQQSA
----
----------
DP
K
FSR
P
VA
D
T
TRT
MTV
I
S
E
Q
V
I
K
DQ
G
AT
NL
T
D
AL
K
N
V
PGV
G
AFF
A
G
EN
G
N
S
T
T
G
D
A
I
Y
M
-
RG
AD
TSNS
I
--
-
-
YIDGI
RD
-------
I
GS
----
V
SR
D
TFNT
E
Q
VEVI
K
GP
S
G
TD
YG
R
SAP
T
G
S
INM
I
SK
Q
P
R
N
DSG
I
-
D
A
SA
SI
GS
AWFR
R
GTL
D
VNQV
I
G
D
TT
AV
R
L
N
V
M
G
-E
K
T
H
DA
GR
D
KVKN
ERY
GV
AP
SIA
F
G
LG
TANR
L
YLN
----------
Y
L
HVT
QH
NTP
D
GGI
PT
I
G
LP
G
YS
A
P
SA
GT
ATLN
--
H
SGK
V
D
THNFYGT
D
S
DY
D
D
STT
D
TAT
MR
--------
FEH
D
I
ND
N
T
T
I
R
N
T
T
RWS
R
VK
Q
D
Y
LM
TA
I
M
G
G
A
S
NITQ
P
TSDVN
S
W-
--------
-----------TWS
R
TANTK
D
VSN
K
I
L
TN
QT
N
L
T
S
T
F
Y
T
A
S
I
G
H
D
V
S
---------------
TGV
E
F
T
R
--
-
ETQ
T
N
--------------------
Y
G
VN
---
P
VTL
P
AV
N
IYH
PD
-
--------S
S
IH
P
GGLTRNGA
N
ANG
QT
DTFA
I
YA
F
D
TL
Q
ITRD
F
E
L
N
GG
I
R
LD
N
Y
HTE
YD
S
AT
A
CGGSGRGAITCP
AGVAKGSPV
T
T
VDT
--
AKSG
N
LV
N
W
K
AG
AL
Y
H
L
T
E
NG
-
N
V
Y
I
N
YA
V
S
Q
Q
-----
P
PGGNNFALA
Q
S
GSG
---
N
S
A
N
RT
D
F
K
P
Q
K
A
N
T
S
EIG
T
K
WQVL
D
K
RL
LL
T
A
ALFR
TDIE
N
EVE
--------
Q
N
D
D
GTY
SQ
Y
--
G
KK
R
V
E
G
Y
EI
S
VA
---
G
N
IT
P
AWQV
I
GGYT
QQK
A
-
----
T
IK
NG
K
DV
AQ
DGSSSLPY
T
PEH
AFT
LWS
Q
Y
QAT
D
-
-
--
D
IS
VG
A
G
A
RY
I
G
---
S
MHKGS
D
-
G
A
V
GT
PA
F
TE
G
-
Y
W
V
A
DA
KL
G
Y
R
V
N
R
----
N
L
D
F
QLNV
Y
NLFD
TD
YVAS
INK
S
G
Y
-------
RYHP
G
E
PR
T
F
LL
TA
N
MH
F
fig|83334.1.peg.953
Escherichia coli O157:H7 (5-760/760)
RNFPARQFHSL
----
TF
F
AG
LCI
G
ITPV
AQA
L
AAE
GQT
NAD
DTL
V
VEAS
T
PSL
Y
APQQSA
----
----------
DP
K
FSR
P
VA
D
T
TRT
MTV
I
S
E
Q
V
I
K
DQ
G
AT
NL
T
D
AL
K
N
V
PGV
G
AFF
A
G
EN
G
N
S
T
T
G
D
A
I
Y
M
-
RG
AD
TSNS
I
--
-
-
YIDGI
RD
-------
I
GS
----
V
SR
D
TFNT
E
Q
VEVI
K
GP
S
G
TD
YG
R
SAP
T
G
S
INM
I
SK
Q
P
R
N
DSG
I
-
D
A
SA
SI
GS
AWFR
R
GTL
D
VNQV
I
G
D
TT
AV
R
L
N
V
M
G
-E
K
T
H
DA
GR
D
KVKN
ERY
GV
AP
SIA
F
G
LG
TANR
L
YLN
----------
Y
L
HVT
QH
NTP
D
GGI
PT
I
G
LP
G
YS
A
P
SA
GT
ATLN
--
H
SGK
V
D
THNFYGT
D
S
DY
D
D
STT
D
TAT
MR
--------
FEH
D
I
ND
N
T
T
I
R
N
T
T
RWS
R
VK
Q
D
Y
LM
TA
I
M
G
G
A
S
NITQ
P
TSDVN
S
W-
--------
-----------TWS
R
TANTK
D
VSN
K
I
L
TN
QT
N
L
T
S
T
F
Y
T
A
S
I
G
H
D
V
S
---------------
TGV
E
F
T
R
--
-
ETQ
T
N
--------------------
Y
G
VN
---
P
VTL
P
AV
N
IYH
PD
-
--------S
S
IH
P
GGLTRNGA
N
ANG
QT
DTFA
I
YA
F
D
TL
Q
ITRD
F
E
L
N
GG
I
R
LD
N
Y
HTE
YD
S
AT
A
CGGSGRGAITCP
AGVAKGSPV
T
T
VDT
--
AKSG
N
LV
N
W
K
AG
AL
Y
H
L
T
E
NG
-
N
V
Y
I
N
YA
V
S
Q
Q
-----
P
PGGNNFALA
Q
S
GSG
---
N
S
A
N
RT
D
F
K
P
Q
K
A
N
T
S
EIG
T
K
WQVL
D
K
RL
LL
T
A
ALFR
TDIE
N
EVE
--------
Q
N
D
D
GTY
SQ
Y
--
G
KK
R
V
E
G
Y
EI
S
VA
---
G
N
IT
P
AWQV
I
GGYT
QQK
A
-
----
T
IK
NG
K
DV
AQ
DGSSSLPY
T
PEH
AFT
LWS
Q
Y
QAT
D
-
-
--
D
IS
VG
A
G
A
RY
I
G
---
S
MHKGS
D
-
G
A
V
GT
PA
F
TE
G
-
Y
W
V
A
DA
KL
G
Y
R
V
N
R
----
N
L
D
F
QLNV
Y
NLFD
TD
YVAS
INK
S
G
Y
-------
RYHP
G
E
PR
T
F
LL
TA
N
MH
F
fig|155864.1.peg.877
Escherichia coli O157:H7 EDL933 (5-760/760)
RNFPARQFHSL
----
TF
F
AG
LCI
G
ITPV
AQA
L
AAE
GQT
NAD
DTL
V
VEAS
T
PSL
Y
APQQSA
----
----------
DP
K
FSR
P
VA
D
T
TRT
MTV
I
S
E
Q
V
I
K
DQ
G
AT
NL
T
D
AL
K
N
V
PGV
G
AFF
A
G
EN
G
N
S
T
T
G
D
A
I
Y
M
-
RG
AD
TSNS
I
--
-
-
YIDGI
RD
-------
I
GS
----
V
SR
D
TFNT
E
Q
VEVI
K
GP
S
G
TD
YG
R
SAP
T
G
S
INM
I
SK
Q
P
R
N
DSG
I
-
D
A
SA
SI
GS
AWFR
R
GTL
D
VNQV
I
G
D
TT
AV
R
L
N
V
M
G
-E
K
T
H
DA
GR
D
KVKN
ERY
GV
AP
SIA
F
G
LG
TANR
L
YLN
----------
Y
L
HVT
QH
NTP
D
GGI
PT
I
G
LP
G
YS
A
P
SA
GT
ATLN
--
H
SGK
V
D
THNFYGT
D
S
DY
D
D
STT
D
TAT
MR
--------
FEH
D
I
ND
N
T
T
I
R
N
T
T
RWS
R
VK
Q
D
Y
LM
TA
I
M
G
G
A
S
NITQ
P
TSDVN
S
W-
--------
-----------TWS
R
TANTK
D
VSN
K
I
L
TN
QT
N
L
T
S
T
F
Y
T
A
S
I
G
H
D
V
S
---------------
TGV
E
F
T
R
--
-
ETQ
T
N
--------------------
Y
G
VN
---
P
VTL
P
AV
N
IYH
PD
-
--------S
S
IH
P
GGLTRNGA
N
ANG
QT
DTFA
I
YA
F
D
TL
Q
ITRD
F
E
L
N
GG
I
R
LD
N
Y
HTE
YD
S
AT
A
CGGSGRGAITCP
AGVAKGSPV
T
T
VDT
--
AKSG
N
LV
N
W
K
AG
AL
Y
H
L
T
E
NG
-
N
V
Y
I
N
YA
V
S
Q
Q
-----
P
PGGNNFALA
Q
S
GSG
---
N
S
A
N
RT
D
F
K
P
Q
K
A
N
T
S
EIG
T
K
WQVL
D
K
RL
LL
T
A
ALFR
TDIE
N
EVE
--------
Q
N
D
D
GTY
SQ
Y
--
G
KK
R
V
E
G
Y
EI
S
VA
---
G
N
IT
P
AWQV
I
GGYT
QQK
A
-
----
T
IK
NG
K
DV
AQ
DGSSSLPY
T
PEH
AFT
LWS
Q
Y
QAT
D
-
-
--
D
IS
VG
A
G
A
RY
I
G
---
S
MHKGS
D
-
G
A
V
GT
PA
F
TE
G
-
Y
W
V
A
DA
KL
G
Y
R
V
N
R
----
N
L
D
F
QLNV
Y
NLFD
TD
YVAS
INK
S
G
Y
-------
RYHP
G
E
PR
T
F
LL
TA
N
MH
F
fig|155864.8.peg.903
Escherichia coli O157:H7 EDL933 (5-760/760)
RNFPARQFHSL
----
TF
F
AG
LCI
G
ITPV
AQA
L
AAE
GQT
NAD
DTL
V
VEAS
T
PSL
Y
APQQSA
----
----------
DP
K
FSR
P
VA
D
T
TRT
MTV
I
S
E
Q
V
I
K
DQ
G
AT
NL
T
D
AL
K
N
V
PGV
G
AFF
A
G
EN
G
N
S
T
T
G
D
A
I
Y
M
-
RG
AD
TSNS
I
--
-
-
YIDGI
RD
-------
I
GS
----
V
SR
D
TFNT
E
Q
VEVI
K
GP
S
G
TD
YG
R
SAP
T
G
S
INM
I
SK
Q
P
R
N
DSG
I
-
D
A
SA
SI
GS
AWFR
R
GTL
D
VNQV
I
G
D
TT
AV
R
L
N
V
M
G
-E
K
T
H
DA
GR
D
KVKN
ERY
GV
AP
SIA
F
G
LG
TANR
L
YLN
----------
Y
L
HVT
QH
NTP
D
GGI
PT
I
G
LP
G
YS
A
P
SA
GT
ATLN
--
H
SGK
V
D
THNFYGT
D
S
DY
D
D
STT
D
TAT
MR
--------
FEH
D
I
ND
N
T
T
I
R
N
T
T
RWS
R
VK
Q
D
Y
LM
TA
I
M
G
G
A
S
NITQ
P
TSDVN
S
W-
--------
-----------TWS
R
TANTK
D
VSN
K
I
L
TN
QT
N
L
T
S
T
F
Y
T
A
S
I
G
H
D
V
S
---------------
TGV
E
F
T
R
--
-
ETQ
T
N
--------------------
Y
G
VN
---
P
VTL
P
AV
N
IYH
PD
-
--------S
S
IH
P
GGLTRNGA
N
ANG
QT
DTFA
I
YA
F
D
TL
Q
ITRD
F
E
L
N
GG
I
R
LD
N
Y
HTE
YD
S
AT
A
CGGSGRGAITCP
AGVAKGSPV
T
T
VDT
--
AKSG
N
LV
N
W
K
AG
AL
Y
H
L
T
E
NG
-
N
V
Y
I
N
YA
V
S
Q
Q
-----
P
PGGNNFALA
Q
S
GSG
---
N
S
A
N
RT
D
F
K
P
Q
K
A
N
T
S
EIG
T
K
WQVL
D
K
RL
LL
T
A
ALFR
TDIE
N
EVE
--------
Q
N
D
D
GTY
SQ
Y
--
G
KK
R
V
E
G
Y
EI
S
VA
---
G
N
IT
P
AWQV
I
GGYT
QQK
A
-
----
T
IK
NG
K
DV
AQ
DGSSSLPY
T
PEH
AFT
LWS
Q
Y
QAT
D
-
-
--
D
IS
VG
A
G
A
RY
I
G
---
S
MHKGS
D
-
G
A
V
GT
PA
F
TE
G
-
Y
W
V
A
DA
KL
G
Y
R
V
N
R
----
N
L
D
F
QLNV
Y
NLFD
TD
YVAS
INK
S
G
Y
-------
RYHP
G
E
PR
T
F
LL
TA
N
MH
F
fig|444454.5.peg.5374
Escherichia coli O157:H7 str. EC4024 (5-760/760)
RNFPARQFHSL
----
TF
F
AG
LCI
G
ITPV
AQA
L
AAE
GQT
NAD
DTL
V
VEAS
T
PSL
Y
APQQSA
----
----------
DP
K
FSR
P
VA
D
T
TRT
MTV
I
S
E
Q
V
I
K
DQ
G
AT
NL
T
D
AL
K
N
V
PGV
G
AFF
A
G
EN
G
N
S
T
T
G
D
A
I
Y
M
-
RG
AD
TSNS
I
--
-
-
YIDGI
RD
-------
I
GS
----
V
SR
D
TFNT
E
Q
VEVI
K
GP
S
G
TD
YG
R
SAP
T
G
S
INM
I
SK
Q
P
R
N
DSG
I
-
D
A
SA
SI
GS
AWFR
R
GTL
D
VNQV
I
G
D
TT
AV
R
L
N
V
M
G
-E
K
T
H
DA
GR
D
KVKN
ERY
GV
AP
SIA
F
G
LG
TANR
L
YLN
----------
Y
L
HVT
QH
NTP
D
GGI
PT
I
G
LP
G
YS
A
P
SA
GT
ATLN
--
H
SGK
V
D
THNFYGT
D
S
DY
D
D
STT
D
TAT
MR
--------
FEH
D
I
ND
N
T
T
I
R
N
T
T
RWS
R
VK
Q
D
Y
LM
TA
I
M
G
G
A
S
NITQ
P
TSDVN
S
W-
--------
-----------TWS
R
TANTK
D
VSN
K
I
L
TN
QT
N
L
T
S
T
F
Y
T
A
S
I
G
H
D
V
S
---------------
TGV
E
F
T
R
--
-
ETQ
T
N
--------------------
Y
G
VN
---
P
VTL
P
AV
N
IYH
PD
-
--------S
S
IH
P
GGLTRNGA
N
ANG
QT
DTFA
I
YA
F
D
TL
Q
ITRD
F
E
L
N
GG
I
R
LD
N
Y
HTE
YD
S
AT
A
CGGSGRGAITCP
AGVAKGSPV
T
T
VDT
--
AKSG
N
LV
N
W
K
AG
AL
Y
H
L
T
E
NG
-
N
V
Y
I
N
YA
V
S
Q
Q
-----
P
PGGNNFALA
Q
S
GSG
---
N
S
A
N
RT
D
F
K
P
Q
K
A
N
T
S
EIG
T
K
WQVL
D
K
RL
LL
T
A
ALFR
TDIE
N
EVE
--------
Q
N
D
D
GTY
SQ
Y
--
G
KK
R
V
E
G
Y
EI
S
VA
---
G
N
IT
P
AWQV
I
GGYT
QQK
A
-
----
T
IK
NG
K
DV
AQ
DGSSSLPY
T
PEH
AFT
LWS
Q
Y
QAT
D
-
-
--
D
IS
VG
A
G
A
RY
I
G
---
S
MHKGS
D
-
G
A
V
GT
PA
F
TE
G
-
Y
W
V
A
DA
KL
G
Y
R
V
N
R
----
N
L
D
F
QLNV
Y
NLFD
TD
YVAS
INK
S
G
Y
-------
RYHP
G
E
PR
T
F
LL
TA
N
MH
F
fig|444449.5.peg.4308
Escherichia coli O157:H7 str. EC4042 (5-760/760)
RNFPARQFHSL
----
TF
F
AG
LCI
G
ITPV
AQA
L
AAE
GQT
NAD
DTL
V
VEAS
T
PSL
Y
APQQSA
----
----------
DP
K
FSR
P
VA
D
T
TRT
MTV
I
S
E
Q
V
I
K
DQ
G
AT
NL
T
D
AL
K
N
V
PGV
G
AFF
A
G
EN
G
N
S
T
T
G
D
A
I
Y
M
-
RG
AD
TSNS
I
--
-
-
YIDGI
RD
-------
I
GS
----
V
SR
D
TFNT
E
Q
VEVI
K
GP
S
G
TD
YG
R
SAP
T
G
S
INM
I
SK
Q
P
R
N
DSG
I
-
D
A
SA
SI
GS
AWFR
R
GTL
D
VNQV
I
G
D
TT
AV
R
L
N
V
M
G
-E
K
T
H
DA
GR
D
KVKN
ERY
GV
AP
SIA
F
G
LG
TANR
L
YLN
----------
Y
L
HVT
QH
NTP
D
GGI
PT
I
G
LP
G
YS
A
P
SA
GT
ATLN
--
H
SGK
V
D
THNFYGT
D
S
DY
D
D
STT
D
TAT
MR
--------
FEH
D
I
ND
N
T
T
I
R
N
T
T
RWS
R
VK
Q
D
Y
LM
TA
I
M
G
G
A
S
NITQ
P
TSDVN
S
W-
--------
-----------TWS
R
TANTK
D
VSN
K
I
L
TN
QT
N
L
T
S
T
F
Y
T
A
S
I
G
H
D
V
S
---------------
TGV
E
F
T
R
--
-
ETQ
T
N
--------------------
Y
G
VN
---
P
VTL
P
AV
N
IYH
PD
-
--------S
S
IH
P
GGLTRNGA
N
ANG
QT
DTFA
I
YA
F
D
TL
Q
ITRD
F
E
L
N
GG
I
R
LD
N
Y
HTE
YD
S
AT
A
CGGSGRGAITCP
AGVAKGSPV
T
T
VDT
--
AKSG
N
LV
N
W
K
AG
AL
Y
H
L
T
E
NG
-
N
V
Y
I
N
YA
V
S
Q
Q
-----
P
PGGNNFALA
Q
S
GSG
---
N
S
A
N
RT
D
F
K
P
Q
K
A
N
T
S
EIG
T
K
WQVL
D
K
RL
LL
T
A
ALFR
TDIE
N
EVE
--------
Q
N
D
D
GTY
SQ
Y
--
G
KK
R
V
E
G
Y
EI
S
VA
---
G
N
IT
P
AWQV
I
GGYT
QQK
A
-
----
T
IK
NG
K
DV
AQ
DGSSSLPY
T
PEH
AFT
LWS
Q
Y
QAT
D
-
-
--
D
IS
VG
A
G
A
RY
I
G
---
S
MHKGS
D
-
G
A
V
GT
PA
F
TE
G
-
Y
W
V
A
DA
KL
G
Y
R
V
N
R
----
N
L
D
F
QLNV
Y
NLFD
TD
YVAS
INK
S
G
Y
-------
RYHP
G
E
PR
T
F
LL
TA
N
MH
F
fig|444448.5.peg.3584
Escherichia coli O157:H7 str. EC4045 (5-760/760)
RNFPARQFHSL
----
TF
F
AG
LCI
G
ITPV
AQA
L
AAE
GQT
NAD
DTL
V
VEAS
T
PSL
Y
APQQSA
----
----------
DP
K
FSR
P
VA
D
T
TRT
MTV
I
S
E
Q
V
I
K
DQ
G
AT
NL
T
D
AL
K
N
V
PGV
G
AFF
A
G
EN
G
N
S
T
T
G
D
A
I
Y
M
-
RG
AD
TSNS
I
--
-
-
YIDGI
RD
-------
I
GS
----
V
SR
D
TFNT
E
Q
VEVI
K
GP
S
G
TD
YG
R
SAP
T
G
S
INM
I
SK
Q
P
R
N
DSG
I
-
D
A
SA
SI
GS
AWFR
R
GTL
D
VNQV
I
G
D
TT
AV
R
L
N
V
M
G
-E
K
T
H
DA
GR
D
KVKN
ERY
GV
AP
SIA
F
G
LG
TANR
L
YLN
----------
Y
L
HVT
QH
NTP
D
GGI
PT
I
G
LP
G
YS
A
P
SA
GT
ATLN
--
H
SGK
V
D
THNFYGT
D
S
DY
D
D
STT
D
TAT
MR
--------
FEH
D
I
ND
N
T
T
I
R
N
T
T
RWS
R
VK
Q
D
Y
LM
TA
I
M
G
G
A
S
NITQ
P
TSDVN
S
W-
--------
-----------TWS
R
TANTK
D
VSN
K
I
L
TN
QT
N
L
T
S
T
F
Y
T
A
S
I
G
H
D
V
S
---------------
TGV
E
F
T
R
--
-
ETQ
T
N
--------------------
Y
G
VN
---
P
VTL
P
AV
N
IYH
PD
-
--------S
S
IH
P
GGLTRNGA
N
ANG
QT
DTFA
I
YA
F
D
TL
Q
ITRD
F
E
L
N
GG
I
R
LD
N
Y
HTE
YD
S
AT
A
CGGSGRGAITCP
AGVAKGSPV
T
T
VDT
--
AKSG
N
LV
N
W
K
AG
AL
Y
H
L
T
E
NG
-
N
V
Y
I
N
YA
V
S
Q
Q
-----
P
PGGNNFALA
Q
S
GSG
---
N
S
A
N
RT
D
F
K
P
Q
K
A
N
T
S
EIG
T
K
WQVL
D
K
RL
LL
T
A
ALFR
TDIE
N
EVE
--------
Q
N
D
D
GTY
SQ
Y
--
G
KK
R
V
E
G
Y
EI
S
VA
---
G
N
IT
P
AWQV
I
GGYT
QQK
A
-
----
T
IK
NG
K
DV
AQ
DGSSSLPY
T
PEH
AFT
LWS
Q
Y
QAT
D
-
-
--
D
IS
VG
A
G
A
RY
I
G
---
S
MHKGS
D
-
G
A
V
GT
PA
F
TE
G
-
Y
W
V
A
DA
KL
G
Y
R
V
N
R
----
N
L
D
F
QLNV
Y
NLFD
TD
YVAS
INK
S
G
Y
-------
RYHP
G
E
PR
T
F
LL
TA
N
MH
F
fig|444453.5.peg.926
Escherichia coli O157:H7 str. EC4076 (5-760/760)
RNFPARQFHSL
----
TF
F
AG
LCI
G
ITPV
AQA
L
AAE
GQT
NAD
DTL
V
VEAS
T
PSL
Y
APQQSA
----
----------
DP
K
FSR
P
VA
D
T
TRT
MTV
I
S
E
Q
V
I
K
DQ
G
AT
NL
T
D
AL
K
N
V
PGV
G
AFF
A
G
EN
G
N
S
T
T
G
D
A
I
Y
M
-
RG
AD
TSNS
I
--
-
-
YIDGI
RD
-------
I
GS
----
V
SR
D
TFNT
E
Q
VEVI
K
GP
S
G
TD
YG
R
SAP
T
G
S
INM
I
SK
Q
P
R
N
DSG
I
-
D
A
SA
SI
GS
AWFR
R
GTL
D
VNQV
I
G
D
TT
AV
R
L
N
V
M
G
-E
K
T
H
DA
GR
D
KVKN
ERY
GV
AP
SIA
F
G
LG
TANR
L
YLN
----------
Y
L
HVT
QH
NTP
D
GGI
PT
I
G
LP
G
YS
A
P
SA
GT
ATLN
--
H
SGK
V
D
THNFYGT
D
S
DY
D
D
STT
D
TAT
MR
--------
FEH
D
I
ND
N
T
T
I
R
N
T
T
RWS
R
VK
Q
D
Y
LM
TA
I
M
G
G
A
S
NITQ
P
TSDVN
S
W-
--------
-----------TWS
R
TANTK
D
VSN
K
I
L
TN
QT
N
L
T
S
T
F
Y
T
A
S
I
G
H
D
V
S
---------------
TGV
E
F
T
R
--
-
ETQ
T
N
--------------------
Y
G
VN
---
P
VTL
P
AV
N
IYH
PD
-
--------S
S
IH
P
GGLTRNGA
N
ANG
QT
DTFA
I
YA
F
D
TL
Q
ITRD
F
E
L
N
GG
I
R
LD
N
Y
HTE
YD
S
AT
A
CGGSGRGAITCP
AGVAKGSPV
T
T
VDT
--
AKSG
N
LV
N
W
K
AG
AL
Y
H
L
T
E
NG
-
N
V
Y
I
N
YA
V
S
Q
Q
-----
P
PGGNNFALA
Q
S
GSG
---
N
S
A
N
RT
D
F
K
P
Q
K
A
N
T
S
EIG
T
K
WQVL
D
K
RL
LL
T
A
ALFR
TDIE
N
EVE
--------
Q
N
D
D
GTY
SQ
Y
--
G
KK
R
V
E
G
Y
EI
S
VA
---
G
N
IT
P
AWQV
I
GGYT
QQK
A
-
----
T
IK
NG
K
DV
AQ
DGSSSLPY
T
PEH
AFT
LWS
Q
Y
QAT
D
-
-
--
D
IS
VG
A
G
A
RY
I
G
---
S
MHKGS
D
-
G
A
V
GT
PA
F
TE
G
-
Y
W
V
A
DA
KL
G
Y
R
V
N
R
----
N
L
D
F
QLNV
Y
NLFD
TD
YVAS
INK
S
G
Y
-------
RYHP
G
E
PR
T
F
LL
TA
N
MH
F
fig|444450.8.peg.1041
Escherichia coli O157:H7 str. EC4115 (5-760/760)
RNFPARQFHSL
----
TF
F
AG
LCI
G
ITPV
AQA
L
AAE
GQT
NAD
DTL
V
VEAS
T
PSL
Y
APQQSA
----
----------
DP
K
FSR
P
VA
D
T
TRT
MTV
I
S
E
Q
V
I
K
DQ
G
AT
NL
T
D
AL
K
N
V
PGV
G
AFF
A
G
EN
G
N
S
T
T
G
D
A
I
Y
M
-
RG
AD
TSNS
I
--
-
-
YIDGI
RD
-------
I
GS
----
V
SR
D
TFNT
E
Q
VEVI
K
GP
S
G
TD
YG
R
SAP
T
G
S
INM
I
SK
Q
P
R
N
DSG
I
-
D
A
SA
SI
GS
AWFR
R
GTL
D
VNQV
I
G
D
TT
AV
R
L
N
V
M
G
-E
K
T
H
DA
GR
D
KVKN
ERY
GV
AP
SIA
F
G
LG
TANR
L
YLN
----------
Y
L
HVT
QH
NTP
D
GGI
PT
I
G
LP
G
YS
A
P
SA
GT
ATLN
--
H
SGK
V
D
THNFYGT
D
S
DY
D
D
STT
D
TAT
MR
--------
FEH
D
I
ND
N
T
T
I
R
N
T
T
RWS
R
VK
Q
D
Y
LM
TA
I
M
G
G
A
S
NITQ
P
TSDVN
S
W-
--------
-----------TWS
R
TANTK
D
VSN
K
I
L
TN
QT
N
L
T
S
T
F
Y
T
A
S
I
G
H
D
V
S
---------------
TGV
E
F
T
R
--
-
ETQ
T
N
--------------------
Y
G
VN
---
P
VTL
P
AV
N
IYH
PD
-
--------S
S
IH
P
GGLTRNGA
N
ANG
QT
DTFA
I
YA
F
D
TL
Q
ITRD
F
E
L
N
GG
I
R
LD
N
Y
HTE
YD
S
AT
A
CGGSGRGAITCP
AGVAKGSPV
T
T
VDT
--
AKSG
N
LV
N
W
K
AG
AL
Y
H
L
T
E
NG
-
N
V
Y
I
N
YA
V
S
Q
Q
-----
P
PGGNNFALA
Q
S
GSG
---
N
S
A
N
RT
D
F
K
P
Q
K
A
N
T
S
EIG
T
K
WQVL
D
K
RL
LL
T
A
ALFR
TDIE
N
EVE
--------
Q
N
D
D
GTY
SQ
Y
--
G
KK
R
V
E
G
Y
EI
S
VA
---
G
N
IT
P
AWQV
I
GGYT
QQK
A
-
----
T
IK
NG
K
DV
AQ
DGSSSLPY
T
PEH
AFT
LWS
Q
Y
QAT
D
-
-
--
D
IS
VG
A
G
A
RY
I
G
---
S
MHKGS
D
-
G
A
V
GT
PA
F
TE
G
-
Y
W
V
A
DA
KL
G
Y
R
V
N
R
----
N
L
D
F
QLNV
Y
NLFD
TD
YVAS
INK
S
G
Y
-------
RYHP
G
E
PR
T
F
LL
TA
N
MH
F
fig|444451.5.peg.4681
Escherichia coli O157:H7 str. EC4196 (5-760/760)
RNFPARQFHSL
----
TF
F
AG
LCI
G
ITPV
AQA
L
AAE
GQT
NAD
DTL
V
VEAS
T
PSL
Y
APQQSA
----
----------
DP
K
FSR
P
VA
D
T
TRT
MTV
I
S
E
Q
V
I
K
DQ
G
AT
NL
T
D
AL
K
N
V
PGV
G
AFF
A
G
EN
G
N
S
T
T
G
D
A
I
Y
M
-
RG
AD
TSNS
I
--
-
-
YIDGI
RD
-------
I
GS
----
V
SR
D
TFNT
E
Q
VEVI
K
GP
S
G
TD
YG
R
SAP
T
G
S
INM
I
SK
Q
P
R
N
DSG
I
-
D
A
SA
SI
GS
AWFR
R
GTL
D
VNQV
I
G
D
TT
AV
R
L
N
V
M
G
-E
K
T
H
DA
GR
D
KVKN
ERY
GV
AP
SIA
F
G
LG
TANR
L
YLN
----------
Y
L
HVT
QH
NTP
D
GGI
PT
I
G
LP
G
YS
A
P
SA
GT
ATLN
--
H
SGK
V
D
THNFYGT
D
S
DY
D
D
STT
D
TAT
MR
--------
FEH
D
I
ND
N
T
T
I
R
N
T
T
RWS
R
VK
Q
D
Y
LM
TA
I
M
G
G
A
S
NITQ
P
TSDVN
S
W-
--------
-----------TWS
R
TANTK
D
VSN
K
I
L
TN
QT
N
L
T
S
T
F
Y
T
A
S
I
G
H
D
V
S
---------------
TGV
E
F
T
R
--
-
ETQ
T
N
--------------------
Y
G
VN
---
P
VTL
P
AV
N
IYH
PD
-
--------S
S
IH
P
GGLTRNGA
N
ANG
QT
DTFA
I
YA
F
D
TL
Q
ITRD
F
E
L
N
GG
I
R
LD
N
Y
HTE
YD
S
AT
A
CGGSGRGAITCP
AGVAKGSPV
T
T
VDT
--
AKSG
N
LV
N
W
K
AG
AL
Y
H
L
T
E
NG
-
N
V
Y
I
N
YA
V
S
Q
Q
-----
P
PGGNNFALA
Q
S
GSG
---
N
S
A
N
RT
D
F
K
P
Q
K
A
N
T
S
EIG
T
K
WQVL
D
K
RL
LL
T
A
ALFR
TDIE
N
EVE
--------
Q
N
D
D
GTY
SQ
Y
--
G
KK
R
V
E
G
Y
EI
S
VA
---
G
N
IT
P
AWQV
I
GGYT
QQK
A
-
----
T
IK
NG
K
DV
AQ
DGSSSLPY
T
PEH
AFT
LWS
Q
Y
QAT
D
-
-
--
D
IS
VG
A
G
A
RY
I
G
---
S
MHKGS
D
-
G
A
V
GT
PA
F
TE
G
-
Y
W
V
A
DA
KL
G
Y
R
V
N
R
----
N
L
D
F
QLNV
Y
NLFD
TD
YVAS
INK
S
G
Y
-------
RYHP
G
E
PR
T
F
LL
TA
N
MH
F
fig|478004.5.peg.3303
Escherichia coli O157:H7 str. EC4401 (5-760/760)
RNFPARQFHSL
----
TF
F
AG
LCI
G
ITPV
AQA
L
AAE
GQT
NAD
DTL
V
VEAS
T
PSL
Y
APQQSA
----
----------
DP
K
FSR
P
VA
D
T
TRT
MTV
I
S
E
Q
V
I
K
DQ
G
AT
NL
T
D
AL
K
N
V
PGV
G
AFF
A
G
EN
G
N
S
T
T
G
D
A
I
Y
M
-
RG
AD
TSNS
I
--
-
-
YIDGI
RD
-------
I
GS
----
V
SR
D
TFNT
E
Q
VEVI
K
GP
S
G
TD
YG
R
SAP
T
G
S
INM
I
SK
Q
P
R
N
DSG
I
-
D
A
SA
SI
GS
AWFR
R
GTL
D
VNQV
I
G
D
TT
AV
R
L
N
V
M
G
-E
K
T
H
DA
GR
D
KVKN
ERY
GV
AP
SIA
F
G
LG
TANR
L
YLN
----------
Y
L
HVT
QH
NTP
D
GGI
PT
I
G
LP
G
YS
A
P
SA
GT
ATLN
--
H
SGK
V
D
THNFYGT
D
S
DY
D
D
STT
D
TAT
MR
--------
FEH
D
I
ND
N
T
T
I
R
N
T
T
RWS
R
VK
Q
D
Y
LM
TA
I
M
G
G
A
S
NITQ
P
TSDVN
S
W-
--------
-----------TWS
R
TANTK
D
VSN
K
I
L
TN
QT
N
L
T
S
T
F
Y
T
A
S
I
G
H
D
V
S
---------------
TGV
E
F
T
R
--
-
ETQ
T
N
--------------------
Y
G
VN
---
P
VTL
P
AV
N
IYH
PD
-
--------S
S
IH
P
GGLTRNGA
N
ANG
QT
DTFA
I
YA
F
D
TL
Q
ITRD
F
E
L
N
GG
I
R
LD
N
Y
HTE
YD
S
AT
A
CGGSGRGAITCP
AGVAKGSPV
T
T
VDT
--
AKSG
N
LV
N
W
K
AG
AL
Y
H
L
T
E
NG
-
N
V
Y
I
N
YA
V
S
Q
Q
-----
P
PGGNNFALA
Q
S
GSG
---
N
S
A
N
RT
D
F
K
P
Q
K
A
N
T
S
EIG
T
K
WQVL
D
K
RL
LL
T
A
ALFR
TDIE
N
EVE
--------
Q
N
D
D
GTY
SQ
Y
--
G
KK
R
V
E
G
Y
EI
S
VA
---
G
N
IT
P
AWQV
I
GGYT
QQK
A
-
----
T
IK
NG
K
DV
AQ
DGSSSLPY
T
PEH
AFT
LWS
Q
Y
QAT
D
-
-
--
D
IS
VG
A
G
A
RY
I
G
---
S
MHKGS
D
-
G
A
V
GT
PA
F
TE
G
-
Y
W
V
A
DA
KL
G
Y
R
V
N
R
----
N
L
D
F
QLNV
Y
NLFD
TD
YVAS
INK
S
G
Y
-------
RYHP
G
E
PR
T
F
LL
TA
N
MH
F
fig|478006.5.peg.4607
Escherichia coli O157:H7 str. EC4501 (5-760/760)
RNFPARQFHSL
----
TF
F
AG
LCI
G
ITPV
AQA
L
AAE
GQT
NAD
DTL
V
VEAS
T
PSL
Y
APQQSA
----
----------
DP
K
FSR
P
VA
D
T
TRT
MTV
I
S
E
Q
V
I
K
DQ
G
AT
NL
T
D
AL
K
N
V
PGV
G
AFF
A
G
EN
G
N
S
T
T
G
D
A
I
Y
M
-
RG
AD
TSNS
I
--
-
-
YIDGI
RD
-------
I
GS
----
V
SR
D
TFNT
E
Q
VEVI
K
GP
S
G
TD
YG
R
SAP
T
G
S
INM
I
SK
Q
P
R
N
DSG
I
-
D
A
SA
SI
GS
AWFR
R
GTL
D
VNQV
I
G
D
TT
AV
R
L
N
V
M
G
-E
K
T
H
DA
GR
D
KVKN
ERY
GV
AP
SIA
F
G
LG
TANR
L
YLN
----------
Y
L
HVT
QH
NTP
D
GGI
PT
I
G
LP
G
YS
A
P
SA
GT
ATLN
--
H
SGK
V
D
THNFYGT
D
S
DY
D
D
STT
D
TAT
MR
--------
FEH
D
I
ND
N
T
T
I
R
N
T
T
RWS
R
VK
Q
D
Y
LM
TA
I
M
G
G
A
S
NITQ
P
TSDVN
S
W-
--------
-----------TWS
R
TANTK
D
VSN
K
I
L
TN
QT
N
L
T
S
T
F
Y
T
A
S
I
G
H
D
V
S
---------------
TGV
E
F
T
R
--
-
ETQ
T
N
--------------------
Y
G
VN
---
P
VTL
P
AV
N
IYH
PD
-
--------S
S
IH
P
GGLTRNGA
N
ANG
QT
DTFA
I
YA
F
D
TL
Q
ITRD
F
E
L
N
GG
I
R
LD
N
Y
HTE
YD
S
AT
A
CGGSGRGAITCP
AGVAKGSPV
T
T
VDT
--
AKSG
N
LV
N
W
K
AG
AL
Y
H
L
T
E
NG
-
N
V
Y
I
N
YA
V
S
Q
Q
-----
P
PGGNNFALA
Q
S
GSG
---
N
S
A
N
RT
D
F
K
P
Q
K
A
N
T
S
EIG
T
K
WQVL
D
K
RL
LL
T
A
ALFR
TDIE
N
EVE
--------
Q
N
D
D
GTY
SQ
Y
--
G
KK
R
V
E
G
Y
EI
S
VA
---
G
N
IT
P
AWQV
I
GGYT
QQK
A
-
----
T
IK
NG
K
DV
AQ
DGSSSLPY
T
PEH
AFT
LWS
Q
Y
QAT
D
-
-
--
D
IS
VG
A
G
A
RY
I
G
---
S
MHKGS
D
-
G
A
V
GT
PA
F
TE
G
-
Y
W
V
A
DA
KL
G
Y
R
V
N
R
----
N
L
D
F
QLNV
Y
NLFD
TD
YVAS
INK
S
G
Y
-------
RYHP
G
E
PR
T
F
LL
TA
N
MH
F
fig|478007.5.peg.2629
Escherichia coli O157:H7 str. EC508 (5-760/760)
RNFPARQFHSL
----
TF
F
AG
LCI
G
ITPV
AQA
L
AAE
GQT
NAD
DTL
V
VEAS
T
PSL
Y
APQQSA
----
----------
DP
K
FSR
P
VA
D
T
TRT
MTV
I
S
E
Q
V
I
K
DQ
G
AT
NL
T
D
AL
K
N
V
PGV
G
AFF
A
G
EN
G
N
S
T
T
G
D
A
I
Y
M
-
RG
AD
TSNS
I
--
-
-
YIDGI
RD
-------
I
GS
----
V
SR
D
TFNT
E
Q
VEVI
K
GP
S
G
TD
YG
R
SAP
T
G
S
INM
I
SK
Q
P
R
N
DSG
I
-
D
A
SA
SI
GS
AWFR
R
GTL
D
VNQV
I
G
D
TT
AV
R
L
N
V
M
G
-E
K
T
H
DA
GR
D
KVKN
ERY
GV
AP
SIA
F
G
LG
TANR
L
YLN
----------
Y
L
HVT
QH
NTP
D
GGI
PT
I
G
LP
G
YS
A
P
SA
GT
ATLN
--
H
SGK
V
D
THNFYGT
D
S
DY
D
D
STT
D
TAT
MR
--------
FEH
D
I
ND
N
T
T
I
R
N
T
T
RWS
R
VK
Q
D
Y
LM
TA
I
M
G
G
A
S
NITQ
P
TSDVN
S
W-
--------
-----------TWS
R
TANTK
D
VSN
K
I
L
TN
QT
N
L
T
S
T
F
Y
T
A
S
I
G
H
D
V
S
---------------
TGV
E
F
T
R
--
-
ETQ
T
N
--------------------
Y
G
VN
---
P
VTL
P
AV
N
IYH
PD
-
--------S
S
IH
P
GGLTRNGA
N
ANG
QT
DTFA
I
YA
F
D
TL
Q
ITRD
F
E
L
N
GG
I
R
LD
N
Y
HTE
YD
S
AT
A
CGGSGRGAITCP
AGVAKGSPV
T
T
VDT
--
AKSG
N
LV
N
W
K
AG
AL
Y
H
L
T
E
NG
-
N
V
Y
I
N
YA
V
S
Q
Q
-----
P
PGGNNFALA
Q
S
GSG
---
N
S
A
N
RT
D
F
K
P
Q
K
A
N
T
S
EIG
T
K
WQVL
D
K
RL
LL
T
A
ALFR
TDIE
N
EVE
--------
Q
N
D
D
GTY
SQ
Y
--
G
KK
R
V
E
G
Y
EI
S
VA
---
G
N
IT
P
AWQV
I
GGYT
QQK
A
-
----
T
IK
NG
K
DV
AQ
DGSSSLPY
T
PEH
AFT
LWS
Q
Y
QAT
D
-
-
--
D
IS
VG
A
G
A
RY
I
G
---
S
MHKGS
D
-
G
A
V
GT
PA
F
TE
G
-
Y
W
V
A
DA
KL
G
Y
R
V
N
R
----
N
L
D
F
QLNV
Y
NLFD
TD
YVAS
INK
S
G
Y
-------
RYHP
G
E
PR
T
F
LL
TA
N
MH
F
fig|478008.5.peg.2275
Escherichia coli O157:H7 str. EC869 (5-760/760)
RNFPARQFHSL
----
TF
F
AG
LCI
G
ITPV
AQA
L
AAE
GQT
NAD
DTL
V
VEAS
T
PSL
Y
APQQSA
----
----------
DP
K
FSR
P
VA
D
T
TRT
MTV
I
S
E
Q
V
I
K
DQ
G
AT
NL
T
D
AL
K
N
V
PGV
G
AFF
A
G
EN
G
N
S
T
T
G
D
A
I
Y
M
-
RG
AD
TSNS
I
--
-
-
YIDGI
RD
-------
I
GS
----
V
SR
D
TFNT
E
Q
VEVI
K
GP
S
G
TD
YG
R
SAP
T
G
S
INM
I
SK
Q
P
R
N
DSG
I
-
D
A
SA
SI
GS
AWFR
R
GTL
D
VNQV
I
G
D
TT
AV
R
L
N
V
M
G
-E
K
T
H
DA
GR
D
KVKN
ERY
GV
AP
SIA
F
G
LG
TANR
L
YLN
----------
Y
L
HVT
QH
NTP
D
GGI
PT
I
G
LP
G
YS
A
P
SA
GT
ATLN
--
H
SGK
V
D
THNFYGT
D
S
DY
D
D
STT
D
TAT
MR
--------
FEH
D
I
ND
N
T
T
I
R
N
T
T
RWS
R
VK
Q
D
Y
LM
TA
I
M
G
G
A
S
NITQ
P
TSDVN
S
W-
--------
-----------TWS
R
TANTK
D
VSN
K
I
L
TN
QT
N
L
T
S
T
F
Y
T
A
S
I
G
H
D
V
S
---------------
TGV
E
F
T
R
--
-
ETQ
T
N
--------------------
Y
G
VN
---
P
VTL
P
AV
N
IYH
PD
-
--------S
S
IH
P
GGLTRNGA
N
ANG
QT
DTFA
I
YA
F
D
TL
Q
ITRD
F
E
L
N
GG
I
R
LD
N
Y
HTE
YD
S
AT
A
CGGSGRGAITCP
AGVAKGSPV
T
T
VDT
--
AKSG
N
LV
N
W
K
AG
AL
Y
H
L
T
E
NG
-
N
V
Y
I
N
YA
V
S
Q
Q
-----
P
PGGNNFALA
Q
S
GSG
---
N
S
A
N
RT
D
F
K
P
Q
K
A
N
T
S
EIG
T
K
WQVL
D
K
RL
LL
T
A
ALFR
TDIE
N
EVE
--------
Q
N
D
D
GTY
SQ
Y
--
G
KK
R
V
E
G
Y
EI
S
VA
---
G
N
IT
P
AWQV
I
GGYT
QQK
A
-
----
T
IK
NG
K
DV
AQ
DGSSSLPY
T
PEH
AFT
LWS
Q
Y
QAT
D
-
-
--
D
IS
VG
A
G
A
RY
I
G
---
S
MHKGS
D
-
G
A
V
GT
PA
F
TE
G
-
Y
W
V
A
DA
KL
G
Y
R
V
N
R
----
N
L
D
F
QLNV
Y
NLFD
TD
YVAS
INK
S
G
Y
-------
RYHP
G
E
PR
T
F
LL
TA
N
MH
F
fig|637388.3.peg.2575
Escherichia coli O157:H7 str. FRIK2000 (5-760/760)
RNFPARQFHSL
----
TF
F
AG
LCI
G
ITPV
AQA
L
AAE
GQT
NAD
DTL
V
VEAS
T
PSL
Y
APQQSA
----
----------
DP
K
FSR
P
VA
D
T
TRT
MTV
I
S
E
Q
V
I
K
DQ
G
AT
NL
T
D
AL
K
N
V
PGV
G
AFF
A
G
EN
G
N
S
T
T
G
D
A
I
Y
M
-
RG
AD
TSNS
I
--
-
-
YIDGI
RD
-------
I
GS
----
V
SR
D
TFNT
E
Q
VEVI
K
GP
S
G
TD
YG
R
SAP
T
G
S
INM
I
SK
Q
P
R
N
DSG
I
-
D
A
SA
SI
GS
AWFR
R
GTL
D
VNQV
I
G
D
TT
AV
R
L
N
V
M
G
-E
K
T
H
DA
GR
D
KVKN
ERY
GV
AP
SIA
F
G
LG
TANR
L
YLN
----------
Y
L
HVT
QH
NTP
D
GGI
PT
I
G
LP
G
YS
A
P
SA
GT
ATLN
--
H
SGK
V
D
THNFYGT
D
S
DY
D
D
STT
D
TAT
MR
--------
FEH
D
I
ND
N
T
T
I
R
N
T
T
RWS
R
VK
Q
D
Y
LM
TA
I
M
G
G
A
S
NITQ
P
TSDVN
S
W-
--------
-----------TWS
R
TANTK
D
VSN
K
I
L
TN
QT
N
L
T
S
T
F
Y
T
A
S
I
G
H
D
V
S
---------------
TGV
E
F
T
R
--
-
ETQ
T
N
--------------------
Y
G
VN
---
P
VTL
P
AV
N
IYH
PD
-
--------S
S
IH
P
GGLTRNGA
N
ANG
QT
DTFA
I
YA
F
D
TL
Q
ITRD
F
E
L
N
GG
I
R
LD
N
Y
HTE
YD
S
AT
A
CGGSGRGAITCP
AGVAKGSPV
T
T
VDT
--
AKSG
N
LV
N
W
K
AG
AL
Y
H
L
T
E
NG
-
N
V
Y
I
N
YA
V
S
Q
Q
-----
P
PGGNNFALA
Q
S
GSG
---
N
S
A
N
RT
D
F
K
P
Q
K
A
N
T
S
EIG
T
K
WQVL
D
K
RL
LL
T
A
ALFR
TDIE
N
EVE
--------
Q
N
D
D
GTY
SQ
Y
--
G
KK
R
V
E
G
Y
EI
S
VA
---
G
N
IT
P
AWQV
I
GGYT
QQK
A
-
----
T
IK
NG
K
DV
AQ
DGSSSLPY
T
PEH
AFT
LWS
Q
Y
QAT
D
-
-
--
D
IS
VG
A
G
A
RY
I
G
---
S
MHKGS
D
-
G
A
V
GT
PA
F
TE
G
-
Y
W
V
A
DA
KL
G
Y
R
V
N
R
----
N
L
D
F
QLNV
Y
NLFD
TD
YVAS
INK
S
G
Y
-------
RYHP
G
E
PR
T
F
LL
TA
N
MH
F
fig|570506.3.peg.4454
Escherichia coli O157:H7 str. FRIK966 (5-760/760)
RNFPARQFHSL
----
TF
F
AG
LCI
G
ITPV
AQA
L
AAE
GQT
NAD
DTL
V
VEAS
T
PSL
Y
APQQSA
----
----------
DP
K
FSR
P
VA
D
T
TRT
MTV
I
S
E
Q
V
I
K
DQ
G
AT
NL
T
D
AL
K
N
V
PGV
G
AFF
A
G
EN
G
N
S
T
T
G
D
A
I
Y
M
-
RG
AD
TSNS
I
--
-
-
YIDGI
RD
-------
I
GS
----
V
SR
D
TFNT
E
Q
VEVI
K
GP
S
G
TD
YG
R
SAP
T
G
S
INM
I
SK
Q
P
R
N
DSG
I
-
D
A
SA
SI
GS
AWFR
R
GTL
D
VNQV
I
G
D
TT
AV
R
L
N
V
M
G
-E
K
T
H
DA
GR
D
KVKN
ERY
GV
AP
SIA
F
G
LG
TANR
L
YLN
----------
Y
L
HVT
QH
NTP
D
GGI
PT
I
G
LP
G
YS
A
P
SA
GT
ATLN
--
H
SGK
V
D
THNFYGT
D
S
DY
D
D
STT
D
TAT
MR
--------
FEH
D
I
ND
N
T
T
I
R
N
T
T
RWS
R
VK
Q
D
Y
LM
TA
I
M
G
G
A
S
NITQ
P
TSDVN
S
W-
--------
-----------TWS
R
TANTK
D
VSN
K
I
L
TN
QT
N
L
T
S
T
F
Y
T
A
S
I
G
H
D
V
S
---------------
TGV
E
F
T
R
--
-
ETQ
T
N
--------------------
Y
G
VN
---
P
VTL
P
AV
N
IYH
PD
-
--------S
S
IH
P
GGLTRNGA
N
ANG
QT
DTFA
I
YA
F
D
TL
Q
ITRD
F
E
L
N
GG
I
R
LD
N
Y
HTE
YD
S
AT
A
CGGSGRGAITCP
AGVAKGSPV
T
T
VDT
--
AKSG
N
LV
N
W
K
AG
AL
Y
H
L
T
E
NG
-
N
V
Y
I
N
YA
V
S
Q
Q
-----
P
PGGNNFALA
Q
S
GSG
---
N
S
A
N
RT
D
F
K
P
Q
K
A
N
T
S
EIG
T
K
WQVL
D
K
RL
LL
T
A
ALFR
TDIE
N
EVE
--------
Q
N
D
D
GTY
SQ
Y
--
G
KK
R
V
E
G
Y
EI
S
VA
---
G
N
IT
P
AWQV
I
GGYT
QQK
A
-
----
T
IK
NG
K
DV
AQ
DGSSSLPY
T
PEH
AFT
LWS
Q
Y
QAT
D
-
-
--
D
IS
VG
A
G
A
RY
I
G
---
S
MHKGS
D
-
G
A
V
GT
PA
F
TE
G
-
Y
W
V
A
DA
KL
G
Y
R
V
N
R
----
N
L
D
F
QLNV
Y
NLFD
TD
YVAS
INK
S
G
Y
-------
RYHP
G
E
PR
T
F
LL
TA
N
MH
F
fig|386585.9.peg.997
Escherichia coli O157:H7 str. Sakai (5-760/760)
RNFPARQFHSL
----
TF
F
AG
LCI
G
ITPV
AQA
L
AAE
GQT
NAD
DTL
V
VEAS
T
PSL
Y
APQQSA
----
----------
DP
K
FSR
P
VA
D
T
TRT
MTV
I
S
E
Q
V
I
K
DQ
G
AT
NL
T
D
AL
K
N
V
PGV
G
AFF
A
G
EN
G
N
S
T
T
G
D
A
I
Y
M
-
RG
AD
TSNS
I
--
-
-
YIDGI
RD
-------
I
GS
----
V
SR
D
TFNT
E
Q
VEVI
K
GP
S
G
TD
YG
R
SAP
T
G
S
INM
I
SK
Q
P
R
N
DSG
I
-
D
A
SA
SI
GS
AWFR
R
GTL
D
VNQV
I
G
D
TT
AV
R
L
N
V
M
G
-E
K
T
H
DA
GR
D
KVKN
ERY
GV
AP
SIA
F
G
LG
TANR
L
YLN
----------
Y
L
HVT
QH
NTP
D
GGI
PT
I
G
LP
G
YS
A
P
SA
GT
ATLN
--
H
SGK
V
D
THNFYGT
D
S
DY
D
D
STT
D
TAT
MR
--------
FEH
D
I
ND
N
T
T
I
R
N
T
T
RWS
R
VK
Q
D
Y
LM
TA
I
M
G
G
A
S
NITQ
P
TSDVN
S
W-
--------
-----------TWS
R
TANTK
D
VSN
K
I
L
TN
QT
N
L
T
S
T
F
Y
T
A
S
I
G
H
D
V
S
---------------
TGV
E
F
T
R
--
-
ETQ
T
N
--------------------
Y
G
VN
---
P
VTL
P
AV
N
IYH
PD
-
--------S
S
IH
P
GGLTRNGA
N
ANG
QT
DTFA
I
YA
F
D
TL
Q
ITRD
F
E
L
N
GG
I
R
LD
N
Y
HTE
YD
S
AT
A
CGGSGRGAITCP
AGVAKGSPV
T
T
VDT
--
AKSG
N
LV
N
W
K
AG
AL
Y
H
L
T
E
NG
-
N
V
Y
I
N
YA
V
S
Q
Q
-----
P
PGGNNFALA
Q
S
GSG
---
N
S
A
N
RT
D
F
K
P
Q
K
A
N
T
S
EIG
T
K
WQVL
D
K
RL
LL
T
A
ALFR
TDIE
N
EVE
--------
Q
N
D
D
GTY
SQ
Y
--
G
KK
R
V
E
G
Y
EI
S
VA
---
G
N
IT
P
AWQV
I
GGYT
QQK
A
-
----
T
IK
NG
K
DV
AQ
DGSSSLPY
T
PEH
AFT
LWS
Q
Y
QAT
D
-
-
--
D
IS
VG
A
G
A
RY
I
G
---
S
MHKGS
D
-
G
A
V
GT
PA
F
TE
G
-
Y
W
V
A
DA
KL
G
Y
R
V
N
R
----
N
L
D
F
QLNV
Y
NLFD
TD
YVAS
INK
S
G
Y
-------
RYHP
G
E
PR
T
F
LL
TA
N
MH
F
fig|544404.4.peg.907
Escherichia coli O157:H7 str. TW14359 (5-760/760)
RNFPARQFHSL
----
TF
F
AG
LCI
G
ITPV
AQA
L
AAE
GQT
NAD
DTL
V
VEAS
T
PSL
Y
APQQSA
----
----------
DP
K
FSR
P
VA
D
T
TRT
MTV
I
S
E
Q
V
I
K
DQ
G
AT
NL
T
D
AL
K
N
V
PGV
G
AFF
A
G
EN
G
N
S
T
T
G
D
A
I
Y
M
-
RG
AD
TSNS
I
--
-
-
YIDGI
RD
-------
I
GS
----
V
SR
D
TFNT
E
Q
VEVI
K
GP
S
G
TD
YG
R
SAP
T
G
S
INM
I
SK
Q
P
R
N
DSG
I
-
D
A
SA
SI
GS
AWFR
R
GTL
D
VNQV
I
G
D
TT
AV
R
L
N
V
M
G
-E
K
T
H
DA
GR
D
KVKN
ERY
GV
AP
SIA
F
G
LG
TANR
L
YLN
----------
Y
L
HVT
QH
NTP
D
GGI
PT
I
G
LP
G
YS
A
P
SA
GT
ATLN
--
H
SGK
V
D
THNFYGT
D
S
DY
D
D
STT
D
TAT
MR
--------
FEH
D
I
ND
N
T
T
I
R
N
T
T
RWS
R
VK
Q
D
Y
LM
TA
I
M
G
G
A
S
NITQ
P
TSDVN
S
W-
--------
-----------TWS
R
TANTK
D
VSN
K
I
L
TN
QT
N
L
T
S
T
F
Y
T
A
S
I
G
H
D
V
S
---------------
TGV
E
F
T
R
--
-
ETQ
T
N
--------------------
Y
G
VN
---
P
VTL
P
AV
N
IYH
PD
-
--------S
S
IH
P
GGLTRNGA
N
ANG
QT
DTFA
I
YA
F
D
TL
Q
ITRD
F
E
L
N
GG
I
R
LD
N
Y
HTE
YD
S
AT
A
CGGSGRGAITCP
AGVAKGSPV
T
T
VDT
--
AKSG
N
LV
N
W
K
AG
AL
Y
H
L
T
E
NG
-
N
V
Y
I
N
YA
V
S
Q
Q
-----
P
PGGNNFALA
Q
S
GSG
---
N
S
A
N
RT
D
F
K
P
Q
K
A
N
T
S
EIG
T
K
WQVL
D
K
RL
LL
T
A
ALFR
TDIE
N
EVE
--------
Q
N
D
D
GTY
SQ
Y
--
G
KK
R
V
E
G
Y
EI
S
VA
---
G
N
IT
P
AWQV
I
GGYT
QQK
A
-
----
T
IK
NG
K
DV
AQ
DGSSSLPY
T
PEH
AFT
LWS
Q
Y
QAT
D
-
-
--
D
IS
VG
A
G
A
RY
I
G
---
S
MHKGS
D
-
G
A
V
GT
PA
F
TE
G
-
Y
W
V
A
DA
KL
G
Y
R
V
N
R
----
N
L
D
F
QLNV
Y
NLFD
TD
YVAS
INK
S
G
Y
-------
RYHP
G
E
PR
T
F
LL
TA
N
MH
F
fig|502346.5.peg.308
Escherichia coli O157:H7 str. TW14588 (5-760/760)
RNFPARQFHSL
----
TF
F
AG
LCI
G
ITPV
AQA
L
AAE
GQT
NAD
DTL
V
VEAS
T
PSL
Y
APQQSA
----
----------
DP
K
FSR
P
VA
D
T
TRT
MTV
I
S
E
Q
V
I
K
DQ
G
AT
NL
T
D
AL
K
N
V
PGV
G
AFF
A
G
EN
G
N
S
T
T
G
D
A
I
Y
M
-
RG
AD
TSNS
I
--
-
-
YIDGI
RD
-------
I
GS
----
V
SR
D
TFNT
E
Q
VEVI
K
GP
S
G
TD
YG
R
SAP
T
G
S
INM
I
SK
Q
P
R
N
DSG
I
-
D
A
SA
SI
GS
AWFR
R
GTL
D
VNQV
I
G
D
TT
AV
R
L
N
V
M
G
-E
K
T
H
DA
GR
D
KVKN
ERY
GV
AP
SIA
F
G
LG
TANR
L
YLN
----------
Y
L
HVT
QH
NTP
D
GGI
PT
I
G
LP
G
YS
A
P
SA
GT
ATLN
--
H
SGK
V
D
THNFYGT
D
S
DY
D
D
STT
D
TAT
MR
--------
FEH
D
I
ND
N
T
T
I
R
N
T
T
RWS
R
VK
Q
D
Y
LM
TA
I
M
G
G
A
S
NITQ
P
TSDVN
S
W-
--------
-----------TWS
R
TANTK
D
VSN
K
I
L
TN
QT
N
L
T
S
T
F
Y
T
A
S
I
G
H
D
V
S
---------------
TGV
E
F
T
R
--
-
ETQ
T
N
--------------------
Y
G
VN
---
P
VTL
P
AV
N
IYH
PD
-
--------S
S
IH
P
GGLTRNGA
N
ANG
QT
DTFA
I
YA
F
D
TL
Q
ITRD
F
E
L
N
GG
I
R
LD
N
Y
HTE
YD
S
AT
A
CGGSGRGAITCP
AGVAKGSPV
T
T
VDT
--
AKSG
N
LV
N
W
K
AG
AL
Y
H
L
T
E
NG
-
N
V
Y
I
N
YA
V
S
Q
Q
-----
P
PGGNNFALA
Q
S
GSG
---
N
S
A
N
RT
D
F
K
P
Q
K
A
N
T
S
EIG
T
K
WQVL
D
K
RL
LL
T
A
ALFR
TDIE
N
EVE
--------
Q
N
D
D
GTY
SQ
Y
--
G
KK
R
V
E
G
Y
EI
S
VA
---
G
N
IT
P
AWQV
I
GGYT
QQK
A
-
----
T
IK
NG
K
DV
AQ
DGSSSLPY
T
PEH
AFT
LWS
Q
Y
QAT
D
-
-
--
D
IS
VG
A
G
A
RY
I
G
---
S
MHKGS
D
-
G
A
V
GT
PA
F
TE
G
-
Y
W
V
A
DA
KL
G
Y
R
V
N
R
----
N
L
D
F
QLNV
Y
NLFD
TD
YVAS
INK
S
G
Y
-------
RYHP
G
E
PR
T
F
LL
TA
N
MH
F
fig|701177.3.peg.1015
Escherichia coli O55:H7 str. CB9615 (5-760/760)
RNFPARQFHSL
----
TF
F
AG
LCI
G
ITPV
AQA
L
AAE
GQT
NAD
DTL
V
VEAS
T
PSL
Y
APQQSA
----
----------
DP
K
FSR
P
VA
D
T
TRT
MTV
I
S
E
Q
V
I
K
DQ
G
AT
NL
T
D
AL
K
N
V
PGV
G
AFF
A
G
EN
G
N
S
T
T
G
D
A
I
Y
M
-
RG
AD
TSNS
I
--
-
-
YIDGI
RD
-------
I
GS
----
V
SR
D
TFNT
E
Q
VEVI
K
GP
S
G
TD
YG
R
SAP
T
G
S
INM
I
SK
Q
P
R
N
DSG
I
-
D
A
SA
SI
GS
AWFR
R
GTL
D
VNQV
I
G
D
TT
AV
R
L
N
V
M
G
-E
K
T
H
DA
GR
D
KVKN
ERY
GV
AP
SIA
F
G
LG
TANR
L
YLN
----------
Y
L
HVT
QH
NTP
D
GGI
PT
I
G
LP
G
YS
A
P
SA
GT
ATLN
--
H
SGK
V
D
THNFYGT
D
S
DY
D
D
STT
D
TAT
MR
--------
FEH
D
I
ND
N
T
T
I
R
N
T
T
RWS
R
VK
Q
D
Y
LM
TA
I
M
G
G
A
S
NITQ
P
TSDVN
S
W-
--------
-----------TWS
R
TANTK
D
VSN
K
I
L
TN
QT
N
L
T
S
T
F
Y
T
A
S
I
G
H
D
V
S
---------------
TGV
E
F
T
R
--
-
ETQ
T
N
--------------------
Y
G
VN
---
P
VTL
P
AV
N
IYH
PD
-
--------S
S
IH
P
GGLTRNGA
N
ANG
QT
DTFA
I
YA
F
D
TL
Q
ITRD
F
E
L
N
GG
I
R
LD
N
Y
HTE
YD
S
AT
A
CGGSGRGAITCP
AGVAKGSPV
T
T
VDT
--
AKSG
N
LV
N
W
K
AG
AL
Y
H
L
T
E
NG
-
N
V
Y
I
N
YA
V
S
Q
Q
-----
P
PGGNNFALA
Q
S
GSG
---
N
S
A
N
RT
D
F
K
P
Q
K
A
N
T
S
EIG
T
K
WQVL
D
K
RL
LL
T
A
ALFR
TDIE
N
EVE
--------
Q
N
D
D
GTY
SQ
Y
--
G
KK
R
V
E
G
Y
EI
S
VA
---
G
N
IT
P
AWQV
I
GGYT
QQK
A
-
----
T
IK
NG
K
DV
AQ
DGSSSLPY
T
PEH
AFT
LWS
Q
Y
QAT
D
-
-
--
D
IS
VG
A
G
A
RY
I
G
---
S
MHKGS
D
-
G
A
V
GT
PA
F
TE
G
-
Y
W
V
A
DA
KL
G
Y
R
V
N
R
----
N
L
D
F
QLNV
Y
NLFD
TD
YVAS
INK
S
G
Y
-------
RYHP
G
E
PR
T
F
LL
TA
N
MH
F
fig|431946.3.peg.766
Escherichia coli SE15 (5-760/760)
RNFPARQFHSL
----
TF
F
AG
LCI
G
ITPV
AQA
L
AAE
GQA
NAD
DTL
V
VEAS
T
PSL
Y
APQ
K
SA
----
----------
DP
K
FSR
P
VA
D
T
TRT
MTV
I
S
E
Q
V
I
K
DQ
G
AT
NL
T
D
AL
K
N
V
PGV
G
AFF
A
G
EN
G
N
S
T
T
G
D
A
I
Y
M
-
RG
AD
TSNS
I
--
-
-
YIDGI
RD
-------
I
GS
----
V
SR
D
TFNT
E
Q
VEVI
K
GP
S
G
TD
YG
R
SAP
T
G
S
INM
I
SK
Q
P
R
N
DSG
I
-
D
A
SA
SI
GS
AWFR
R
GTL
D
VNQV
I
G
D
TT
AV
R
L
N
V
M
G
-E
K
T
H
DA
GR
D
KVKN
ERY
GV
AP
SVA
F
G
LG
TANR
L
YLN
----------
Y
L
HVT
QH
NTP
D
GGI
PT
I
G
LP
G
FS
A
P
SA
GT
AALN
--
H
SGK
V
D
THNFYGT
D
S
DY
D
D
STT
D
TAT
MR
--------
FEH
D
I
ND
N
T
T
I
R
N
T
T
RWS
R
VK
Q
D
Y
LM
TA
I
M
G
G
A
S
NITQ
P
TSDVN
S
W-
--------
-----------TWS
R
TANTK
D
VSN
K
I
L
TN
QT
N
L
T
S
T
F
Y
TG
A
I
G
H
D
V
S
---------------
TGV
E
F
T
R
--
-
ETQ
T
N
--------------------
Y
G
VN
---
P
VTL
P
TV
N
IYH
PD
-
--------S
S
IH
P
GGLTRNGA
N
ANG
QT
DTFA
I
YA
F
D
TL
Q
ITRD
F
E
L
N
GG
I
R
LD
N
Y
HTE
YD
S
AT
A
CGGSGRGAITCP
AGVAKGSPV
T
T
VDT
--
AKSG
N
LV
N
W
K
AG
AL
Y
H
L
T
E
NG
-
N
V
Y
I
N
YA
V
S
Q
Q
-----
P
PGGNNFALA
Q
S
GSG
---
N
S
A
N
RT
D
F
K
P
Q
K
A
N
T
S
EIG
T
K
WQVL
D
K
RL
LL
T
A
ALFR
TDIE
N
EVE
--------
Q
N
D
D
GTY
SQ
Y
--
G
KK
R
V
E
G
Y
EI
S
VA
---
G
N
IT
P
AWQ
M
I
GGYT
QQK
A
-
----
T
IK
NG
K
DV
AQ
DGSSSLPY
T
PEH
AFT
LWS
Q
Y
QAT
D
-
-
--
D
IS
VG
A
G
A
RY
I
G
---
S
MHKGS
D
-
G
A
V
GT
PA
F
TE
G
-
Y
W
V
A
DA
KL
G
Y
R
V
N
R
----
N
L
D
F
QLNV
Y
NLFD
TD
YVAS
INK
S
G
Y
-------
RYHP
G
E
PR
T
F
LL
TA
N
MH
F
fig|216593.1.peg.1400
Escherichia coli E2348/69 (5-760/760)
RNFPARQFHSL
----
TF
F
AG
LCI
G
ITPV
AQA
L
AAE
GQA
NAD
DTL
V
VEAS
T
PSL
Y
APQ
K
SA
----
----------
DP
K
FSR
P
VA
D
T
TRT
MTV
I
S
E
Q
V
I
K
DQ
G
AT
NL
T
D
AL
K
N
V
PGV
G
AFF
A
G
EN
G
N
S
T
T
G
D
A
I
Y
M
-
RG
AD
TSNS
I
--
-
-
YIDGI
RD
-------
I
GS
----
V
SR
D
TFNT
E
Q
VEVI
K
GP
S
G
TD
YG
R
SAP
T
G
S
INM
I
SK
Q
P
R
N
DSG
I
-
D
A
SA
SI
GS
AWFR
R
GTL
D
VNQV
I
G
D
TT
AV
R
L
N
V
M
G
-E
K
T
H
DA
GR
N
KVKN
ERY
GV
AP
SVA
F
G
LG
TANR
L
YLN
----------
Y
L
HVT
QH
NTP
D
GGI
PT
I
G
LP
G
YS
A
P
SA
GT
AALN
--
H
SGK
V
D
THNFYGT
D
S
DY
D
D
STT
D
TAT
MR
--------
FEH
D
I
ND
N
T
T
I
R
N
T
T
RWS
R
VK
Q
D
Y
LM
TA
I
M
G
G
A
S
NITQ
P
TSDVN
S
W-
--------
-----------TWS
R
TANTK
D
VSN
K
I
L
TN
QT
N
L
T
S
T
F
Y
TG
A
I
G
H
D
V
S
---------------
TGV
E
F
T
R
--
-
ETQ
T
N
--------------------
Y
G
VN
---
P
VTL
P
AV
N
IYH
PD
-
--------S
S
IH
P
GGLTRNGA
N
ANG
QT
DTFA
I
YA
F
D
TL
Q
ITRD
F
E
L
N
GG
I
R
LD
N
Y
HTE
YD
S
AT
A
CGGSGRGAITCP
ASVAKGSPV
T
T
VDT
--
AKSG
N
LV
N
W
K
AG
AL
Y
H
L
T
E
NG
-
N
V
Y
I
N
YA
V
S
Q
Q
-----
P
PGGNNFALA
Q
S
GSG
---
N
S
A
N
RT
D
F
K
P
Q
K
A
N
T
S
EIG
T
K
WQVL
D
K
RL
LL
T
A
ALFR
TDIE
N
EVE
--------
Q
N
D
D
GTY
SQ
Y
--
G
KK
R
V
E
G
Y
EI
S
VA
---
G
N
IT
P
AWQ
M
I
GGYT
QQK
A
-
----
T
IK
NG
K
DV
AQ
DGSSSLPY
T
PEH
AFT
LWS
Q
Y
QAT
D
-
-
--
D
IS
VG
A
G
A
RY
I
G
---
S
MHKGS
D
-
G
A
V
GT
PA
F
TE
G
-
Y
W
V
A
DA
KL
G
Y
R
V
N
R
----
N
L
D
F
QLNV
Y
NLFD
TD
YVAS
INK
S
G
Y
-------
RYHP
G
E
PR
T
F
LL
TA
N
MH
F
fig|562.376.peg.4800
Escherichia coli WV_060327 (5-760/760)
RNFPARQFHSL
----
TF
F
AG
LCI
G
ITPV
AQA
L
AAE
GQA
NAD
DTL
V
VEAS
T
PSL
Y
APQQSA
----
----------
DP
K
FSR
P
VA
D
T
TRT
MTV
I
S
E
Q
V
I
K
DQ
G
AT
NL
T
D
AL
K
N
V
PGV
G
AFF
A
G
EN
G
N
S
T
T
G
D
A
I
Y
M
-
RG
AD
TSNS
I
--
-
-
YIDGI
RD
-------
I
GS
----
V
SR
D
TFNT
E
Q
VEVI
K
GP
S
G
TD
YG
R
SAP
T
G
S
INM
I
SK
Q
P
R
N
DSG
I
-
D
A
SA
SI
GS
AWFR
R
GTL
D
VNQV
I
G
D
TT
AV
R
L
N
V
M
G
-E
K
T
H
DA
GR
D
KVKN
ERY
GV
AP
SVA
F
G
LG
TANR
L
YLN
----------
Y
L
HVT
QH
NTP
D
GGI
PT
I
G
LP
G
YS
A
P
SA
GT
AALN
--
H
SGK
V
D
THNFYGT
D
S
DY
D
D
SIT
D
TAT
MR
--------
FEH
D
I
ND
N
A
T
I
R
N
T
T
RWS
R
VK
Q
D
Y
LM
TA
I
M
G
G
A
S
NITQ
P
TSDVN
S
W-
--------
-----------TWS
R
TANTK
D
VSN
K
I
L
TN
QT
N
L
T
S
T
F
Y
TG
A
I
G
H
D
V
S
---------------
TGV
E
F
T
R
--
-
ETQ
T
N
--------------------
Y
G
VN
---
P
VTL
P
AV
N
IYH
PD
-
--------S
S
IH
P
GGLTRNGA
N
ANG
QT
DTFA
I
YA
F
D
TL
Q
ITRD
F
E
L
N
GG
I
R
LD
N
Y
HTE
YD
S
AT
A
CGGSGRGAITCP
AGVAKGSPV
T
T
VDT
--
AKSG
N
LV
N
W
K
AG
AL
Y
H
L
T
E
NG
-
N
V
Y
I
N
YA
V
S
Q
Q
-----
P
PGGNNFALA
Q
S
GSG
---
N
S
A
N
RT
D
F
K
P
Q
K
A
N
T
S
EIG
T
K
WQVL
D
K
RL
LL
T
A
ALFR
TDIE
N
EVE
--------
Q
N
D
D
GTY
SQ
Y
--
G
KK
R
V
E
G
Y
EI
S
VA
---
G
N
IT
P
AWQ
M
I
GGYT
QQK
A
-
----
T
IK
NG
K
DV
AQ
DGSSSLPY
T
PEH
AFT
LWS
Q
Y
QAT
D
-
-
--
D
IS
VG
A
G
A
RY
I
G
---
S
MHKGS
D
-
G
A
V
GT
PA
F
TE
G
-
Y
W
V
A
DA
KL
G
Y
R
V
N
R
----
N
L
D
F
QLNV
Y
NLFD
TD
YVAS
INK
S
G
Y
-------
RYHP
G
E
PR
T
F
LL
TA
N
MH
F
fig|362663.8.peg.826
Escherichia coli 536 (5-760/760)
RNFPARQFHSL
----
TF
F
AG
LCI
G
ITPV
AQA
L
AAE
GQA
NAD
DTL
V
VEAS
T
PSL
Y
APQQSA
----
----------
DP
K
FSR
P
VA
D
T
TRT
MTV
I
S
E
Q
V
I
K
DQ
G
AT
NL
T
D
AL
K
N
V
PGV
G
AFF
A
G
EN
G
N
S
T
T
G
D
A
I
Y
M
-
RG
AD
TSNS
I
--
-
-
YIDGI
RD
-------
I
GS
----
V
SR
D
TFNT
E
Q
VEVI
K
GP
S
G
TD
YG
R
SAP
T
G
S
INM
I
SK
Q
P
R
N
DSG
I
-
D
A
SA
SI
GS
AWFR
R
GTL
D
VNQV
I
G
D
TT
AV
R
L
N
V
M
G
-E
K
T
H
DA
GR
D
KVKN
ERY
GV
AP
SVA
F
G
LG
TANR
L
YLN
----------
Y
L
HVT
QH
NTP
D
GGI
PT
I
G
LP
G
YS
A
P
SA
GT
AALN
--
H
SGK
V
D
THNFYGT
D
S
DY
D
D
STT
D
TAT
MR
--------
FEH
D
I
ND
N
T
T
I
R
N
T
T
RWS
R
VK
Q
D
Y
LM
TA
I
M
G
G
A
S
NITQ
P
TSDVN
S
W-
--------
-----------TWS
R
TANTK
D
VSN
K
I
L
TN
QT
N
L
T
S
T
F
Y
TG
A
I
G
H
D
V
S
---------------
TGV
E
F
T
R
--
-
ETQ
T
N
--------------------
Y
G
VN
---
P
VTL
P
AV
N
IYH
PD
-
--------S
S
IH
P
GGLTRNGA
N
ANG
QT
DTFA
I
YA
F
D
TL
Q
ITRD
F
E
L
N
GG
I
R
LD
N
Y
HTE
YD
S
AT
A
Y
GGSGRGAITCP
AGVAKGSPV
T
T
VDT
--
AKSG
N
LV
N
W
K
AG
AL
Y
H
L
T
E
NG
-
N
V
Y
I
N
YA
V
S
Q
Q
-----
P
PGGNNFALA
Q
S
GSG
---
N
S
A
N
RT
D
F
K
P
Q
K
A
N
T
S
EIG
T
K
WQVL
D
K
RL
LL
T
A
ALFR
TDIE
N
EVE
--------
Q
N
D
D
GTY
SQ
Y
--
G
KK
R
V
E
G
Y
EI
S
VA
---
G
N
IT
P
AWQ
M
I
GGYT
QQK
A
-
----
T
IK
NG
K
DV
AQ
DGSSSLPY
T
PEH
AFT
LWS
Q
Y
QAT
D
-
-
--
D
IS
VG
A
G
A
RY
I
G
---
S
MHKGS
D
-
G
A
V
GT
PA
F
TE
D
-
Y
W
V
A
DA
KL
G
Y
R
V
N
R
----
N
L
D
F
QLNV
Y
NLFD
TD
YVAS
INK
S
G
Y
-------
RYHP
G
E
PR
T
F
LL
TA
N
MH
F
fig|362663.9.peg.826
Escherichia coli 536 (5-760/760)
RNFPARQFHSL
----
TF
F
AG
LCI
G
ITPV
AQA
L
AAE
GQA
NAD
DTL
V
VEAS
T
PSL
Y
APQQSA
----
----------
DP
K
FSR
P
VA
D
T
TRT
MTV
I
S
E
Q
V
I
K
DQ
G
AT
NL
T
D
AL
K
N
V
PGV
G
AFF
A
G
EN
G
N
S
T
T
G
D
A
I
Y
M
-
RG
AD
TSNS
I
--
-
-
YIDGI
RD
-------
I
GS
----
V
SR
D
TFNT
E
Q
VEVI
K
GP
S
G
TD
YG
R
SAP
T
G
S
INM
I
SK
Q
P
R
N
DSG
I
-
D
A
SA
SI
GS
AWFR
R
GTL
D
VNQV
I
G
D
TT
AV
R
L
N
V
M
G
-E
K
T
H
DA
GR
D
KVKN
ERY
GV
AP
SVA
F
G
LG
TANR
L
YLN
----------
Y
L
HVT
QH
NTP
D
GGI
PT
I
G
LP
G
YS
A
P
SA
GT
AALN
--
H
SGK
V
D
THNFYGT
D
S
DY
D
D
STT
D
TAT
MR
--------
FEH
D
I
ND
N
T
T
I
R
N
T
T
RWS
R
VK
Q
D
Y
LM
TA
I
M
G
G
A
S
NITQ
P
TSDVN
S
W-
--------
-----------TWS
R
TANTK
D
VSN
K
I
L
TN
QT
N
L
T
S
T
F
Y
TG
A
I
G
H
D
V
S
---------------
TGV
E
F
T
R
--
-
ETQ
T
N
--------------------
Y
G
VN
---
P
VTL
P
AV
N
IYH
PD
-
--------S
S
IH
P
GGLTRNGA
N
ANG
QT
DTFA
I
YA
F
D
TL
Q
ITRD
F
E
L
N
GG
I
R
LD
N
Y
HTE
YD
S
AT
A
Y
GGSGRGAITCP
AGVAKGSPV
T
T
VDT
--
AKSG
N
LV
N
W
K
AG
AL
Y
H
L
T
E
NG
-
N
V
Y
I
N
YA
V
S
Q
Q
-----
P
PGGNNFALA
Q
S
GSG
---
N
S
A
N
RT
D
F
K
P
Q
K
A
N
T
S
EIG
T
K
WQVL
D
K
RL
LL
T
A
ALFR
TDIE
N
EVE
--------
Q
N
D
D
GTY
SQ
Y
--
G
KK
R
V
E
G
Y
EI
S
VA
---
G
N
IT
P
AWQ
M
I
GGYT
QQK
A
-
----
T
IK
NG
K
DV
AQ
DGSSSLPY
T
PEH
AFT
LWS
Q
Y
QAT
D
-
-
--
D
IS
VG
A
G
A
RY
I
G
---
S
MHKGS
D
-
G
A
V
GT
PA
F
TE
D
-
Y
W
V
A
DA
KL
G
Y
R
V
N
R
----
N
L
D
F
QLNV
Y
NLFD
TD
YVAS
INK
S
G
Y
-------
RYHP
G
E
PR
T
F
LL
TA
N
MH
F
fig|340197.3.peg.3834
Escherichia coli F11 (5-760/760)
RNFPARQFHSL
----
TF
F
AG
LCI
G
ITPV
AQA
L
AAE
GQA
NAD
DTL
V
VEAS
T
PSL
Y
APQQSA
----
----------
DP
K
FSR
P
VA
D
T
TRT
MTV
I
S
E
Q
V
I
K
DQ
G
AT
NL
T
D
AL
K
N
V
PGV
G
AFF
A
G
EN
G
N
S
T
T
G
D
A
I
Y
M
-
RG
AD
TSNS
I
--
-
-
YIDGI
RD
-------
I
GS
----
V
SR
D
TFNT
E
Q
VEVI
K
GP
S
G
TD
YG
R
SAP
T
G
S
INM
I
SK
Q
P
R
N
DSG
I
-
D
A
SA
SI
GS
AWFR
R
GTL
D
VNQV
I
G
D
TT
AV
R
L
N
V
M
G
-E
K
T
H
DA
GR
D
KVKN
ERY
GV
AP
SVA
F
G
LG
TANR
L
YLN
----------
Y
L
HVT
QH
NTP
D
GGI
PT
I
G
LP
G
YS
A
P
SA
GT
AALN
--
H
SGK
V
D
THNFYGT
D
S
DY
D
D
STT
D
TAT
MR
--------
FEH
D
I
ND
N
T
T
I
R
N
T
T
RWS
R
VK
Q
D
Y
LM
TA
I
M
G
G
A
S
NITQ
P
TSDVN
S
W-
--------
-----------TWS
R
TANTK
D
VSN
K
I
L
TN
QT
N
L
T
S
T
F
Y
TG
A
I
G
H
D
V
S
---------------
TGV
E
F
T
R
--
-
ETQ
T
N
--------------------
Y
G
VN
---
P
VTL
P
AV
N
IYH
PD
-
--------S
S
IH
P
GGLTRNGA
N
ANG
QT
DTFA
I
YA
F
D
TL
Q
ITRD
F
E
L
N
GG
I
R
LD
N
Y
HTE
YD
S
AT
A
CGGSGRGAITCP
AGVAKGSPV
T
T
VDT
--
AKSG
N
LV
N
W
K
AG
AL
Y
H
L
T
E
NG
-
N
V
Y
I
N
YA
V
S
Q
Q
-----
P
PGGNNFALA
Q
S
GSG
---
N
S
A
N
RT
D
F
K
P
Q
K
A
N
T
S
EIG
T
K
WQVL
D
K
RL
LL
T
A
ALFR
TDIE
N
EVE
--------
Q
N
D
D
GTY
SQ
Y
--
G
KK
R
V
E
G
Y
EI
S
VA
---
G
N
IT
P
AWQ
M
I
GGYT
QQK
A
-
----
T
IK
NG
K
DV
AQ
DGSSSLPY
T
PEH
AFT
LWS
Q
Y
QAT
D
-
-
--
D
IS
VG
A
G
A
RY
I
G
---
S
MHKGS
D
-
G
A
V
GT
PA
F
TE
D
-
Y
W
V
A
DA
KL
G
Y
R
V
N
R
----
N
L
D
F
QLNV
Y
NLFD
TD
YVAS
INK
S
G
Y
-------
RYHP
G
E
PR
T
F
LL
TA
N
MH
F
fig|340197.5.peg.4010
Escherichia coli F11 (5-760/760)
RNFPARQFHSL
----
TF
F
AG
LCI
G
ITPV
AQA
L
AAE
GQA
NAD
DTL
V
VEAS
T
PSL
Y
APQQSA
----
----------
DP
K
FSR
P
VA
D
T
TRT
MTV
I
S
E
Q
V
I
K
DQ
G
AT
NL
T
D
AL
K
N
V
PGV
G
AFF
A
G
EN
G
N
S
T
T
G
D
A
I
Y
M
-
RG
AD
TSNS
I
--
-
-
YIDGI
RD
-------
I
GS
----
V
SR
D
TFNT
E
Q
VEVI
K
GP
S
G
TD
YG
R
SAP
T
G
S
INM
I
SK
Q
P
R
N
DSG
I
-
D
A
SA
SI
GS
AWFR
R
GTL
D
VNQV
I
G
D
TT
AV
R
L
N
V
M
G
-E
K
T
H
DA
GR
D
KVKN
ERY
GV
AP
SVA
F
G
LG
TANR
L
YLN
----------
Y
L
HVT
QH
NTP
D
GGI
PT
I
G
LP
G
YS
A
P
SA
GT
AALN
--
H
SGK
V
D
THNFYGT
D
S
DY
D
D
STT
D
TAT
MR
--------
FEH
D
I
ND
N
T
T
I
R
N
T
T
RWS
R
VK
Q
D
Y
LM
TA
I
M
G
G
A
S
NITQ
P
TSDVN
S
W-
--------
-----------TWS
R
TANTK
D
VSN
K
I
L
TN
QT
N
L
T
S
T
F
Y
TG
A
I
G
H
D
V
S
---------------
TGV
E
F
T
R
--
-
ETQ
T
N
--------------------
Y
G
VN
---
P
VTL
P
AV
N
IYH
PD
-
--------S
S
IH
P
GGLTRNGA
N
ANG
QT
DTFA
I
YA
F
D
TL
Q
ITRD
F
E
L
N
GG
I
R
LD
N
Y
HTE
YD
S
AT
A
CGGSGRGAITCP
AGVAKGSPV
T
T
VDT
--
AKSG
N
LV
N
W
K
AG
AL
Y
H
L
T
E
NG
-
N
V
Y
I
N
YA
V
S
Q
Q
-----
P
PGGNNFALA
Q
S
GSG
---
N
S
A
N
RT
D
F
K
P
Q
K
A
N
T
S
EIG
T
K
WQVL
D
K
RL
LL
T
A
ALFR
TDIE
N
EVE
--------
Q
N
D
D
GTY
SQ
Y
--
G
KK
R
V
E
G
Y
EI
S
VA
---
G
N
IT
P
AWQ
M
I
GGYT
QQK
A
-
----
T
IK
NG
K
DV
AQ
DGSSSLPY
T
PEH
AFT
LWS
Q
Y
QAT
D
-
-
--
D
IS
VG
A
G
A
RY
I
G
---
S
MHKGS
D
-
G
A
V
GT
PA
F
TE
D
-
Y
W
V
A
DA
KL
G
Y
R
V
N
R
----
N
L
D
F
QLNV
Y
NLFD
TD
YVAS
INK
S
G
Y
-------
RYHP
G
E
PR
T
F
LL
TA
N
MH
F
fig|749550.3.peg.3764
Escherichia coli MS 200-1 (5-760/760)
RNFPARQFHSL
----
TF
F
AG
LCI
G
ITPV
AQA
L
AAE
GQA
NAD
DTL
V
VEAS
T
PSL
Y
APQQSA
----
----------
DP
K
FSR
P
VA
D
T
TRT
MTV
I
S
E
Q
V
I
K
DQ
G
AT
NL
T
D
AL
K
N
V
PGV
G
AFF
A
G
EN
G
N
S
T
T
G
D
A
I
Y
M
-
RG
AD
TSNS
I
--
-
-
YIDGI
RD
-------
I
GS
----
V
SR
D
TFNT
E
Q
VEVI
K
GP
S
G
TD
YG
R
SAP
T
G
S
INM
I
SK
Q
P
R
N
DSG
I
-
D
A
SA
SI
GS
AWFR
R
GTL
D
VNQV
I
G
D
TT
AV
R
L
N
V
M
G
-E
K
T
H
DA
GR
D
KVKN
ERY
GV
AP
SVA
F
G
LG
TANR
L
YLN
----------
Y
L
HVT
QH
NTP
D
GGI
PT
I
G
LP
G
YS
A
P
SA
GT
AALN
--
H
SGK
V
D
THNFYGT
D
S
DY
D
D
STT
D
TAT
MR
--------
FEH
D
I
ND
N
T
T
I
R
N
T
T
RWS
R
VK
Q
D
Y
LM
TA
I
M
G
G
A
S
NITQ
P
TSDVN
S
W-
--------
-----------TWS
R
TANTK
D
VSN
K
I
L
TN
QT
N
L
T
S
T
F
Y
TG
A
I
G
H
D
V
S
---------------
TGV
E
F
T
R
--
-
ETQ
T
N
--------------------
Y
G
VN
---
P
VTL
P
AV
N
IYH
PD
-
--------S
S
IH
P
GGLTRNGA
N
ANG
QT
DTFA
I
YA
F
D
TL
Q
ITRD
F
E
L
N
GG
I
R
LD
N
Y
HTE
YD
S
AT
A
CGGSGRGAITCP
AGVAKGSPV
T
T
VDT
--
AKSG
N
LV
N
W
K
AG
AL
Y
H
L
T
E
NG
-
N
V
Y
I
N
YA
V
S
Q
Q
-----
P
PGGNNFALA
Q
S
GSG
---
N
S
A
N
RT
D
F
K
P
Q
K
A
N
T
S
EIG
T
K
WQVL
D
K
RL
LL
T
A
ALFR
TDIE
N
EVE
--------
Q
N
D
D
GTY
SQ
Y
--
G
KK
R
V
E
G
Y
EI
S
VA
---
G
N
IT
P
AWQ
M
I
GGYT
QQK
A
-
----
T
IK
NG
K
DV
AQ
DGSSSLPY
T
PEH
AFT
LWS
Q
Y
QAT
D
-
-
--
D
IS
VG
A
G
A
RY
I
G
---
S
MHKGS
D
-
G
A
V
GT
PA
F
TE
D
-
Y
W
V
A
DA
KL
G
Y
R
V
N
R
----
N
L
D
F
QLNV
Y
NLFD
TD
YVAS
INK
S
G
Y
-------
RYHP
G
E
PR
T
F
LL
TA
N
MH
F
fig|562.372.peg.1095
Escherichia coli 1212A (5-760/760)
RNFPARQFHSL
----
TF
F
AG
LCI
G
ITPV
AQA
L
AAE
GQT
NAD
DTL
V
VEAS
T
PSL
Y
APQQSA
----
----------
DP
K
FSR
P
VA
D
T
TRT
MTV
I
S
E
Q
V
I
K
DQ
G
AT
NL
T
D
AL
K
N
V
PGV
G
AFF
A
G
EN
G
N
S
T
T
G
D
A
I
Y
M
-
RG
AD
TSNS
I
--
-
-
YIDGI
RD
-------
I
GS
----
V
SR
D
TFNT
E
Q
VEVI
K
GP
S
G
TD
YG
R
SAP
T
G
S
INM
I
SK
Q
P
R
N
DSG
I
-
D
A
SA
SI
GS
AWFR
R
GTL
D
VNQV
I
G
D
TT
AV
R
L
N
V
M
G
-E
K
T
H
DA
GR
D
KVKN
ERY
GV
AP
SIA
F
G
LG
TANR
L
YLN
----------
Y
L
HVT
QH
NTP
D
GGI
PT
I
G
LP
G
YS
A
P
SA
GT
ATLN
--
H
SGK
V
D
THNFYGT
D
S
DY
D
D
STT
D
TAT
MR
--------
FEH
D
I
ND
N
T
T
I
R
N
T
T
RWS
R
VK
Q
D
Y
LM
TA
I
M
G
G
A
S
NITQ
P
TSDVN
S
W-
--------
-----------TWS
R
TANTK
D
VSN
K
I
L
TN
QT
N
L
T
S
T
F
Y
T
A
S
I
G
H
D
V
S
---------------
TGV
E
F
T
R
--
-
ETQ
T
N
--------------------
Y
G
VN
---
P
VTL
P
AV
N
IYH
PD
-
--------S
S
IH
P
GGLTRNGA
N
ANG
QT
DTFA
I
YA
F
D
TL
Q
ITRD
F
E
L
N
GG
I
R
LD
N
Y
HTE
YD
S
AT
A
CGGSGRGAITCP
AGVAKGSPV
T
T
VDT
--
AKSG
N
LV
N
W
K
AG
AL
Y
H
L
T
E
NG
-
N
V
Y
I
N
YA
V
S
Q
Q
-----
P
PGGNNFALA
Q
S
GSG
---
N
S
A
N
RT
D
F
K
P
Q
K
A
N
T
S
EIG
T
K
WQVL
D
K
RL
LL
T
A
ALFR
TDIE
N
EVE
--------
Q
N
D
D
GTY
SQ
Y
--
G
KK
R
V
E
G
Y
EI
S
VA
---
G
N
IT
P
AWQV
I
GGYT
QQK
A
-
----
T
IK
NG
K
DV
AQ
DGSSSLPY
T
PEH
AFT
LWS
Q
Y
QAT
D
-
-
--
D
IS
VG
A
G
A
RY
I
G
---
S
MHKGS
D
-
G
A
V
GT
PA
F
TE
G
-
Y
W
V
A
D
V
KL
G
Y
R
V
N
R
----
N
L
D
F
QLNV
Y
NLFD
TD
YVAS
INK
S
G
Y
-------
RYHP
G
E
PR
T
F
LL
TA
N
MH
F
fig|562.374.peg.2629
Escherichia coli 536A (5-760/760)
RNFPARQFHSL
----
TF
F
AG
LCI
G
ITPV
AQA
L
AAE
GQT
NAD
DTL
V
VEAS
T
PSL
Y
APQQSA
----
----------
DP
K
FSR
P
VA
D
T
TRT
MTV
I
S
E
Q
V
I
K
DQ
G
AT
NL
T
D
AL
K
N
V
PGV
G
AFF
A
G
EN
G
N
S
T
T
G
D
A
I
Y
M
-
RG
AD
TSNS
I
--
-
-
YIDGI
RD
-------
I
GS
----
V
SR
D
TFNT
E
Q
VEVI
K
GP
S
G
TD
YG
R
SAP
T
G
S
INM
I
SK
Q
P
R
N
DSG
I
-
D
A
SA
SI
GS
AWFR
R
GTL
D
VNQV
I
G
D
TT
AV
R
L
N
V
M
G
-E
K
T
H
DA
GR
D
KVKN
ERY
GV
AP
SIA
F
G
LG
TANR
L
YLN
----------
Y
L
HVT
QH
NTP
D
GGI
PT
I
G
LP
G
YS
A
P
SA
GT
ATLN
--
H
SGK
V
D
THNFYGT
D
S
DY
D
D
STT
D
TAT
MR
--------
FEH
D
I
ND
N
T
T
I
R
N
T
T
RWS
R
VK
Q
D
Y
LM
TA
I
M
G
G
A
S
NITQ
P
TSDVN
S
W-
--------
-----------TWS
R
TANTK
D
VSN
K
I
L
TN
QT
N
L
T
S
T
F
Y
T
A
S
I
G
H
D
V
S
---------------
TGV
E
F
T
R
--
-
ETQ
T
N
--------------------
Y
G
VN
---
P
VTL
P
AV
N
IYH
PD
-
--------S
S
IH
P
GGLTRNGA
N
ANG
QT
DTFA
I
YA
F
D
TL
Q
ITRD
F
E
L
N
GG
I
R
LD
N
Y
HTE
YD
S
AT
A
CGGSGRGAITCP
AGVAKGSPV
T
T
VDT
--
AKSG
N
LV
N
W
K
AG
AL
Y
H
L
T
E
NG
-
N
V
Y
I
N
YA
V
S
Q
Q
-----
P
PGGNNFALA
Q
S
GSG
---
N
S
A
N
RT
D
F
K
P
Q
K
A
N
T
S
EIG
T
K
WQVL
D
K
RL
LL
T
A
ALFR
TDIE
N
EVE
--------
Q
N
D
D
GTY
SQ
Y
--
G
KK
R
V
E
G
Y
EI
S
VA
---
G
N
IT
P
AWQV
I
GGYT
QQK
A
-
----
T
IK
NG
K
DV
AQ
DGSSSLPY
T
PEH
AFT
LWS
Q
Y
QAT
D
-
-
--
D
IS
VG
A
G
A
RY
I
G
---
S
MHKGS
D
-
G
A
V
GT
PA
F
TE
G
-
Y
W
V
A
D
V
KL
G
Y
R
V
N
R
----
N
L
D
F
QLNV
Y
NLFD
TD
YVAS
INK
S
G
Y
-------
RYHP
G
E
PR
T
F
LL
TA
N
MH
F
fig|585035.6.peg.824
Escherichia coli S88 (5-760/760)
RNFPARQFHSL
----
TF
F
AG
LCI
G
ITPV
AQA
L
AAE
GQA
NAD
DTL
V
VEAS
T
PSL
Y
APQQSA
----
----------
DP
K
FSR
P
VA
D
T
TRT
MTV
I
S
E
Q
V
I
K
DQ
G
AT
NL
T
D
AL
K
N
V
P
A
V
G
AFF
A
G
EN
G
N
S
T
T
G
D
A
I
Y
M
-
RG
AD
TSNS
I
--
-
-
YIDGI
RD
-------
I
GS
----
V
SR
D
TFNT
E
Q
VEVI
K
GP
S
G
TD
YG
R
SAP
T
G
S
INM
I
SK
Q
P
R
N
DSG
I
-
D
A
SA
SI
GS
AWFR
R
GTL
D
VNQV
I
G
D
TT
AV
R
L
N
V
M
G
-E
K
T
H
DA
GR
D
KVKN
ERY
GV
AP
SVA
F
G
LG
TANR
L
YLN
----------
Y
L
HVT
QH
NTP
D
GGI
PT
I
G
LP
G
YS
A
P
SA
GT
AALN
--
H
SGK
V
D
THNFYGT
D
S
DY
D
D
STT
D
TAT
MR
--------
FEH
D
I
ND
N
T
T
I
R
N
T
T
RWS
R
VK
Q
D
Y
LM
TA
I
M
G
G
A
S
NITQ
P
TSDVN
S
W-
--------
-----------TWS
R
TANTK
D
VSN
K
I
L
TN
QT
N
L
T
S
T
F
Y
TG
A
I
G
H
D
V
S
---------------
TGV
E
F
T
R
--
-
ETQ
T
N
--------------------
Y
G
VN
---
P
VTL
P
AV
N
IYH
PD
-
--------S
S
IH
P
GGLTRNGA
N
ANG
QT
DTFA
I
YA
F
D
TL
Q
ITRD
F
E
L
N
GG
I
R
LD
N
Y
HTE
YD
S
AT
A
CGGSGRGAITCP
AGVAKGSPV
T
T
VDT
--
AKSG
N
LV
N
W
K
AG
AL
Y
H
L
T
E
NG
-
N
I
Y
I
N
YA
V
S
Q
Q
-----
P
PGGNNFALA
Q
S
GSG
---
N
S
A
N
RT
D
F
K
P
Q
K
A
N
T
S
EIG
T
K
WQVL
D
K
RL
LL
T
A
ALFR
TDIE
N
EVE
--------
Q
N
D
D
GTY
SQ
Y
--
G
KK
R
V
E
G
Y
EI
S
VA
---
G
N
IT
P
AWQ
M
I
GGYT
QQK
A
-
----
T
IK
NG
K
DV
AQ
DGSSSLPY
T
PEH
AFT
LWS
Q
Y
QAT
D
-
-
--
D
IS
VG
A
G
A
RY
I
G
---
S
MHKGS
D
-
G
A
V
GT
PA
F
TE
G
-
Y
W
V
A
DA
KL
G
Y
R
V
N
R
----
N
L
D
F
QLNV
Y
NLFD
TD
YVAS
INK
S
G
Y
-------
RYHP
G
E
PR
T
F
LL
TA
N
MH
F
fig|199310.1.peg.282
Escherichia coli CFT073 (8-721/721)
A
AL
L
PA
LAS
F
IPLH
A
H
A
S
S
TS
---
--
ED
E
M
I
V
TG
N
T
---
-
A
A
D
T
T
DSAAG
AGFKTNDIDV
G
P
L
GTK
S
WI
E
T
P
Y
S
S
T
T
V
T
K
E
M
I
E
N
QQ
AQ
S
V
S
E
M
L
K
Y
S
P
ST
Q
---
M
Q
AR
G
G
M
D
V
G
R
P
QS
-
-
RG
M
-
-QGS
V
VA
N
S
R
L
DG
L
NI
-------
V
S
T
----
T
AF
P
VEML
ER
MD
V
L
NSL
T
G
AL
YG
P
AS
P
A
G
Q
F
N
F
V
A
K
R
PT
E
ETL
R
-
K
V
T
L
GY
Q
S
RSAF
T
GHA
D
LGGH
F
D
E
N
K
RF
G
Y
RV
N
L
LD
Q
E
G
E
G
NV
D
DSTL
R
R
K
LV
S
V
ALD
W
N
I
Q
PGTQ
L
QLD
ASHYEFIQKG
Y
V
GSF
N
Y
G--
-
---
P
N
V
K
LP
S
AP
N
P
KD
KN
LALS
--
T
A
G
-
-
-
-------
-
-
--
ND
LTT
D
TIS
T
R
--------
L
I
H
Y
FND
D
W
S
M
N
A
G
V
G
W
Q
Q
AD
-
-
-
--
RA
M
RS
V
S
S
KILN
N
QGDI-
-
--
--------
-----------SRS
M
KDSTA
A
GRF
R
V
L
SN
TA
G
L
N
G
H
I
D
TG
S
I
G
H
D
L
S
LSTTGYVWSLYSAKG
TG
S
S
Y
-
-
--
-
---
-
S
--------------------
WG
TT
---
-
---
-
--
N
MYH
PD
-
-AIDEQGDG
K
IR
T
GGPRYRSS
V
NTQ
Q
S
VTLG
DT
V
T
F
TP
Q
WSAM
F
Y
L
-
--
-
-
--
-
-
--
SQS
W
L
Q
T
------------
KNYDKHGNQ
T
N
-----
QVDE
N
GL
S
P
N
A
A
LM
Y
K
I
T
P
N
T
-
M
A
Y
V
SYA
D
S
L
E
QGGTA
P
---------
T
D
ESV
---
K
N
A
G
QT
-
L
N
P
Y
R
S
K
Q
YE
V
G
L
K
SDIG
E
-
-
M
NL
G
A
ALFR
LERP
F
AYL
--------
-
D
T
D
NV
Y
KE
Q
--
G
NQ
V
N
N
G
L
E
L
T
AA
---
G
N
V
W
Q
GL
N
I
Y
S
G
V
T
FLD
P
-
KLKD
T
AN
AST
SN
K
Q
-----
VVG
V
P
K
V
QAN
L
L
A
E
Y
SLP
S
I
P
--
E
WVYS
A
N
V
H
Y
T
G
---
-
----K
R
-
A
A
N
D
T
NT
S
YA
S
SY
T
TW
D
L
GT
RY
-
T
T
KV
SNVP
T
T
F
RV
V
VNN
V
FD
KH
Y
W
AS
IFP
S
G
TDGDNGSP
SAFI
G
GG
R
E
V
RA
S
V
T
FD
F
fig|199310.1.peg.2449
Escherichia coli CFT073 (8-721/721)
A
AL
L
PA
LAS
F
IPLH
A
H
A
S
S
TS
---
--
ED
E
M
I
V
TG
N
T
---
-
A
A
D
T
T
DSAAG
AGFKTNDIDV
G
P
L
GTK
S
WI
E
T
P
Y
S
S
T
T
V
T
K
E
M
I
E
N
QQ
AQ
S
V
S
E
M
L
K
Y
S
P
ST
Q
---
M
Q
AR
G
G
M
D
V
G
R
P
QS
-
-
RG
M
-
-QGS
V
VA
N
S
R
L
DG
L
NI
-------
V
S
T
----
T
AF
P
VEML
ER
MD
V
L
NSL
T
G
AL
YG
P
AS
P
A
G
Q
F
N
F
V
A
K
R
PT
E
ETL
R
-
K
V
T
L
GY
Q
S
RSAF
T
GHA
D
LGGH
F
D
E
N
K
RF
G
Y
RV
N
L
LD
Q
E
G
E
G
NV
D
DSTL
R
R
K
LV
S
V
ALD
W
N
I
Q
PGTQ
L
QLD
ASHYEFIQKG
Y
V
GSF
N
Y
G--
-
---
P
N
V
K
LP
S
AP
N
P
KD
KN
LALS
--
T
A
G
-
-
-
-------
-
-
--
ND
LTT
D
TIS
T
R
--------
L
I
H
Y
FND
D
W
S
M
N
A
G
V
G
W
Q
Q
AD
-
-
-
--
RA
M
RS
V
S
S
KILN
N
QGDI-
-
--
--------
-----------SRS
M
KDSTA
A
GRF
R
V
L
SN
TA
G
L
N
G
H
I
D
TG
S
I
G
H
D
L
S
LSTTGYVWSLYSAKG
TG
S
S
Y
-
-
--
-
---
-
S
--------------------
WG
TT
---
-
---
-
--
N
MYH
PD
-
-AIDEQGDG
K
IR
T
GGPRYRSS
V
NTQ
Q
S
VTLG
DT
V
T
F
TP
Q
WSAM
F
Y
L
-
--
-
-
--
-
-
--
SQS
W
L
Q
T
------------
KNYDKHGNQ
T
N
-----
QVDE
N
GL
S
P
N
A
A
LM
Y
K
I
T
P
N
T
-
M
A
Y
V
SYA
D
S
L
E
QGGTA
P
---------
T
D
ESV
---
K
N
A
G
QT
-
L
N
P
Y
R
S
K
Q
YE
V
G
L
K
SDIG
E
-
-
M
NL
G
A
ALFR
LERP
F
AYL
--------
-
D
T
D
NV
Y
KE
Q
--
G
NQ
V
N
N
G
L
E
L
T
AA
---
G
N
V
W
Q
GL
N
I
Y
S
G
V
T
FLD
P
-
KLKD
T
AN
AST
SN
K
Q
-----
VVG
V
P
K
V
QAN
L
L
A
E
Y
SLP
S
I
P
--
E
WVYS
A
N
V
H
Y
T
G
---
-
----K
R
-
A
A
N
D
T
NT
S
YA
S
SY
T
TW
D
L
GT
RY
-
T
T
KV
SNVP
T
T
F
RV
V
VNN
V
FD
KH
Y
W
AS
IFP
S
G
TDGDNGSP
SAFI
G
GG
R
E
V
RA
S
V
T
FD
F
fig|340197.3.peg.56
Escherichia coli F11 (8-721/721)
A
AL
L
PA
LAS
F
IPLH
A
H
A
S
S
TS
---
--
ED
E
M
I
V
TG
N
T
---
-
A
A
D
T
T
DSAAG
AGFKTNDIDV
G
P
L
GTK
S
WI
E
T
P
Y
S
S
T
T
V
T
K
E
M
I
E
N
QQ
AQ
S
V
S
E
M
L
K
Y
S
P
ST
Q
---
M
Q
AR
G
G
M
D
V
G
R
P
QS
-
-
RG
M
-
-QGS
V
VA
N
S
R
L
DG
L
NI
-------
V
S
T
----
T
AF
P
VEML
ER
MD
V
L
NSL
T
G
AL
YG
P
AS
P
A
G
Q
F
N
F
V
A
K
R
PT
E
ETL
R
-
K
V
T
L
GY
Q
S
RSAF
T
GHA
D
LGGH
F
D
E
N
K
RF
G
Y
RV
N
L
LD
Q
E
G
E
G
NV
D
DSTL
R
R
K
LV
S
V
ALD
W
N
I
Q
PGTQ
L
QLD
ASHYEFIQKG
Y
V
GSF
N
Y
G--
-
---
P
N
V
K
LP
S
AP
N
P
KD
KN
LALS
--
T
A
G
-
-
-
-------
-
-
--
ND
LTT
D
TIS
T
R
--------
L
I
H
Y
FND
D
W
S
M
N
A
G
V
G
W
Q
Q
AD
-
-
-
--
RA
M
RS
V
S
S
KILN
N
QGDI-
-
--
--------
-----------SRS
M
KDSTA
A
GRF
R
V
L
SN
TA
G
L
N
G
H
I
D
TG
S
I
G
H
D
L
S
LSTTGYVWSLYSAKG
TG
S
S
Y
-
-
--
-
---
-
S
--------------------
WG
TT
---
-
---
-
--
N
MYH
PD
-
-AIDEQGDG
K
IR
T
GGPRYRSS
V
NTQ
Q
S
VTLG
DT
V
T
F
TP
Q
WSAM
F
Y
L
-
--
-
-
--
-
-
--
SQS
W
L
Q
T
------------
KNYDKHGNQ
T
N
-----
QVDE
N
GL
S
P
N
A
A
LM
Y
K
I
T
P
N
T
-
M
A
Y
V
SYA
D
S
L
E
QGGTA
P
---------
T
D
ESV
---
K
N
A
G
QT
-
L
N
P
Y
R
S
K
Q
YE
V
G
L
K
SDIG
E
-
-
M
NL
G
A
ALFR
LERP
F
AYL
--------
-
D
T
D
NV
Y
KE
Q
--
G
NQ
V
N
N
G
L
E
L
T
AA
---
G
N
V
W
Q
GL
N
I
Y
S
G
V
T
FLD
P
-
KLKD
T
AN
AST
SN
K
Q
-----
VVG
V
P
K
V
QAN
L
L
A
E
Y
SLP
S
I
P
--
E
WVYS
A
N
V
H
Y
T
G
---
-
----K
R
-
A
A
N
D
T
NT
S
YA
S
SY
T
TW
D
L
GT
RY
-
T
T
KV
SNVP
T
T
F
RV
V
VNN
V
FD
KH
Y
W
AS
IFP
S
G
TDGDNGSP
SAFI
G
GG
R
E
V
RA
S
V
T
FD
F
fig|749546.3.peg.673
Escherichia coli MS 185-1 (8-721/721)
A
AL
L
PA
LAS
F
IPLH
A
H
A
S
S
TS
---
--
ED
E
M
I
V
TG
N
T
---
-
A
A
D
T
T
DSAAG
AGFKTNDIDV
G
P
L
GTK
S
WI
E
T
P
Y
S
S
T
T
V
T
K
E
M
I
E
N
QQ
AQ
S
V
S
E
M
L
K
Y
S
P
ST
Q
---
M
Q
AR
G
G
M
D
V
G
R
P
QS
-
-
RG
M
-
-QGS
V
VA
N
S
R
L
DG
L
NI
-------
V
S
T
----
T
AF
P
VEML
ER
MD
V
L
NSL
T
G
AL
YG
P
AS
P
A
G
Q
F
N
F
V
A
K
R
PT
E
ETL
R
-
K
V
T
L
GY
Q
S
RSAF
T
GHA
D
LGGH
F
D
E
N
K
RF
G
Y
RV
N
L
LD
Q
E
G
E
G
NV
D
DSTL
R
R
K
LV
S
V
ALD
W
N
I
Q
PGTQ
L
QLD
ASHYEFIQKG
Y
V
GSF
N
Y
G--
-
---
P
N
V
K
LP
S
AP
N
P
KD
KN
LALS
--
T
A
G
-
-
-
-------
-
-
--
ND
LTT
D
TIS
T
R
--------
L
I
H
Y
FND
D
W
S
M
N
A
G
V
G
W
Q
Q
AD
-
-
-
--
RA
M
RS
V
S
S
KILN
N
QGDI-
-
--
--------
-----------SRS
M
KDSTA
A
GRF
R
V
L
SN
TA
G
L
N
G
H
I
D
TG
S
I
G
H
D
L
S
LSTTGYVWSLYSAKG
TG
S
S
Y
-
-
--
-
---
-
S
--------------------
WG
TT
---
-
---
-
--
N
MYH
PD
-
-AIDEQGDG
K
IR
T
GGPRYRSS
V
NTQ
Q
S
VTLG
DT
V
T
F
TP
Q
WSAM
F
Y
L
-
--
-
-
--
-
-
--
SQS
W
L
Q
T
------------
KNYDKHGNQ
T
N
-----
QVDE
N
GL
S
P
N
A
A
LM
Y
K
I
T
P
N
T
-
M
A
Y
V
SYA
D
S
L
E
QGGTA
P
---------
T
D
ESV
---
K
N
A
G
QT
-
L
N
P
Y
R
S
K
Q
YE
V
G
L
K
SDIG
E
-
-
M
NL
G
A
ALFR
LERP
F
AYL
--------
-
D
T
D
NV
Y
KE
Q
--
G
NQ
V
N
N
G
L
E
L
T
AA
---
G
N
V
W
Q
GL
N
I
Y
S
G
V
T
FLD
P
-
KLKD
T
AN
AST
SN
K
Q
-----
VVG
V
P
K
V
QAN
L
L
A
E
Y
SLP
S
I
P
--
E
WVYS
A
N
V
H
Y
T
G
---
-
----K
R
-
A
A
N
D
T
NT
S
YA
S
SY
T
TW
D
L
GT
RY
-
T
T
KV
SNVP
T
T
F
RV
V
VNN
V
FD
KH
Y
W
AS
IFP
S
G
TDGDNGSP
SAFI
G
GG
R
E
V
RA
S
V
T
FD
F
fig|749550.3.peg.1107
Escherichia coli MS 200-1 (8-721/721)
A
AL
L
PA
LAS
F
IPLH
A
H
A
S
S
TS
---
--
ED
E
M
I
V
TG
N
T
---
-
A
A
D
T
T
DSAAG
AGFKTNDIDV
G
P
L
GTK
S
WI
E
T
P
Y
S
S
T
T
V
T
K
E
M
I
E
N
QQ
AQ
S
V
S
E
M
L
K
Y
S
P
ST
Q
---
M
Q
AR
G
G
M
D
V
G
R
P
QS
-
-
RG
M
-
-QGS
V
VA
N
S
R
L
DG
L
NI
-------
V
S
T
----
T
AF
P
VEML
ER
MD
V
L
NSL
T
G
AL
YG
P
AS
P
A
G
Q
F
N
F
V
A
K
R
PT
E
ETL
R
-
K
V
T
L
GY
Q
S
RSAF
T
GHA
D
LGGH
F
D
E
N
K
RF
G
Y
RV
N
L
LD
Q
E
G
E
G
NV
D
DSTL
R
R
K
LV
S
V
ALD
W
N
I
Q
PGTQ
L
QLD
ASHYEFIQKG
Y
V
GSF
N
Y
G--
-
---
P
N
V
K
LP
S
AP
N
P
KD
KN
LALS
--
T
A
G
-
-
-
-------
-
-
--
ND
LTT
D
TIS
T
R
--------
L
I
H
Y
FND
D
W
S
M
N
A
G
V
G
W
Q
Q
AD
-
-
-
--
RA
M
RS
V
S
S
KILN
N
QGDI-
-
--
--------
-----------SRS
M
KDSTA
A
GRF
R
V
L
SN
TA
G
L
N
G
H
I
D
TG
S
I
G
H
D
L
S
LSTTGYVWSLYSAKG
TG
S
S
Y
-
-
--
-
---
-
S
--------------------
WG
TT
---
-
---
-
--
N
MYH
PD
-
-AIDEQGDG
K
IR
T
GGPRYRSS
V
NTQ
Q
S
VTLG
DT
V
T
F
TP
Q
WSAM
F
Y
L
-
--
-
-
--
-
-
--
SQS
W
L
Q
T
------------
KNYDKHGNQ
T
N
-----
QVDE
N
GL
S
P
N
A
A
LM
Y
K
I
T
P
N
T
-
M
A
Y
V
SYA
D
S
L
E
QGGTA
P
---------
T
D
ESV
---
K
N
A
G
QT
-
L
N
P
Y
R
S
K
Q
YE
V
G
L
K
SDIG
E
-
-
M
NL
G
A
ALFR
LERP
F
AYL
--------
-
D
T
D
NV
Y
KE
Q
--
G
NQ
V
N
N
G
L
E
L
T
AA
---
G
N
V
W
Q
GL
N
I
Y
S
G
V
T
FLD
P
-
KLKD
T
AN
AST
SN
K
Q
-----
VVG
V
P
K
V
QAN
L
L
A
E
Y
SLP
S
I
P
--
E
WVYS
A
N
V
H
Y
T
G
---
-
----K
R
-
A
A
N
D
T
NT
S
YA
S
SY
T
TW
D
L
GT
RY
-
T
T
KV
SNVP
T
T
F
RV
V
VNN
V
FD
KH
Y
W
AS
IFP
S
G
TDGDNGSP
SAFI
G
GG
R
E
V
RA
S
V
T
FD
F
fig|749528.3.peg.2289
Escherichia coli MS 45-1 (8-721/721)
A
AL
L
PA
LAS
F
IPLH
A
H
A
S
S
TS
---
--
ED
E
M
I
V
TG
N
T
---
-
A
A
D
T
T
DSAAG
AGFKTNDIDV
G
P
L
GTK
S
WI
E
T
P
Y
S
S
T
T
V
T
K
E
M
I
E
N
QQ
AQ
S
V
S
E
M
L
K
Y
S
P
ST
Q
---
M
Q
AR
G
G
M
D
V
G
R
P
QS
-
-
RG
M
-
-QGS
V
VA
N
S
R
L
DG
L
NI
-------
V
S
T
----
T
AF
P
VEML
ER
MD
V
L
NSL
T
G
AL
YG
P
AS
P
A
G
Q
F
N
F
V
A
K
R
PT
E
ETL
R
-
K
V
T
L
GY
Q
S
RSAF
T
GHA
D
LGGH
F
D
E
N
K
RF
G
Y
RV
N
L
LD
Q
E
G
E
G
NV
D
DSTL
R
R
K
LV
S
V
ALD
W
N
I
Q
PGTQ
L
QLD
ASHYEFIQKG
Y
V
GSF
N
Y
G--
-
---
P
N
V
K
LP
S
AP
N
P
KD
KN
LALS
--
T
A
G
-
-
-
-------
-
-
--
ND
LTT
D
TIS
T
R
--------
L
I
H
Y
FND
D
W
S
M
N
A
G
V
G
W
Q
Q
AD
-
-
-
--
RA
M
RS
V
S
S
KILN
N
QGDI-
-
--
--------
-----------SRS
M
KDSTA
A
GRF
R
V
L
SN
TA
G
L
N
G
H
I
D
TG
S
I
G
H
D
L
S
LSTTGYVWSLYSAKG
TG
S
S
Y
-
-
--
-
---
-
S
--------------------
WG
TT
---
-
---
-
--
N
MYH
PD
-
-AIDEQGDG
K
IR
T
GGPRYRSS
V
NTQ
Q
S
VTLG
DT
V
T
F
TP
Q
WSAM
F
Y
L
-
--
-
-
--
-
-
--
SQS
W
L
Q
T
------------
KNYDKHGNQ
T
N
-----
QVDE
N
GL
S
P
N
A
A
LM
Y
K
I
T
P
N
T
-
M
A
Y
V
SYA
D
S
L
E
QGGTA
P
---------
T
D
ESV
---
K
N
A
G
QT
-
L
N
P
Y
R
S
K
Q
YE
V
G
L
K
SDIG
E
-
-
M
NL
G
A
ALFR
LERP
F
AYL
--------
-
D
T
D
NV
Y
KE
Q
--
G
NQ
V
N
N
G
L
E
L
T
AA
---
G
N
V
W
Q
GL
N
I
Y
S
G
V
T
FLD
P
-
KLKD
T
AN
AST
SN
K
Q
-----
VVG
V
P
K
V
QAN
L
L
A
E
Y
SLP
S
I
P
--
E
WVYS
A
N
V
H
Y
T
G
---
-
----K
R
-
A
A
N
D
T
NT
S
YA
S
SY
T
TW
D
L
GT
RY
-
T
T
KV
SNVP
T
T
F
RV
V
VNN
V
FD
KH
Y
W
AS
IFP
S
G
TDGDNGSP
SAFI
G
GG
R
E
V
RA
S
V
T
FD
F
fig|562.375.peg.5050
Escherichia coli EC4100B (21-729/729)
L
AG
CIA
L
ALLP
SA
A
F
AA
P
AT-
--
E
E
T
V
I
VE
G
S
A
---
T
AP
E
D
GE
----
NDYSVTSTSA
GTK
MQM
T
QR
D
I
PQS
V
T
I
VS
Q
Q
R
M
E
DQQ
LQ
T
L
G
E
VM
E
NT
L
G
I
S
---
-
-
-K
S
Q
A
D
S
D
R
A
LY
Y
S
RGF
-
----
Q
ID
N
Y
M
V
DGI
PT
YFESRWN
L
G
D
----
A
LS
D
MALF
ERVEV
V
RG
A
T
G
LM
T
G
T
G
N
P
S
A
A
INMV
R
K
H
A
T
S
REF
K
G
DVSA
EY
GS
WNKE
R
YVA
D
LQSP
L
T
E
DG
KI
R
A
R
I
V
G
GY
Q
N
N
D
S
WL
D
RYNS
E
KT
FF
SG
IVD
A
D
LG
DLTM
L
SAG
----------
-
-
--Y
E
Y
QRI
D
VNS
PT
W
G
--
-
-G
LP
RW
N
T
DG--
--
S
S
NS
Y
D
RARSTAP
D
W
A
YND
KEI
N
KVF
M
T
--------
L
K
Q
R
F
A
DT
W
Q
A
T
L
N
A
T
H
SEV
E
F
D
S
--
KM
MY
V
D
AY
VNKA
D
GMLVG
P
YS
NYGPGFDY
VGGTGWNSGKRKVD
A
LDLFA
D
GSY
E
L
F
GR
Q
-
-
-
-
-
-
-
-
--
-
-
-
H
N
L
M
---------------
F
G
G
S
Y
S
K
QN
N
RYF
S
S
--------------------
W
A
--
---
-
---
-
--
N
IF-
PD
E
IGSFYNFNG
N
FP
Q
TDWSPQSL
A
QDD
T
T
HMKS
LYA
A
T
RV
T
LADP
L
H
L
I
L
G
A
R
YT
N
W
--
R
V
D
T
L
T
Y
------------
---------
-
-
-----
SMEK
N
HT
T
P
Y
AG
LV
F
D
I
N
DN
W
-
S
T
Y
A
SY
T
S
I
FQ
-----
P
---------
-
Q
NDR
---
D
S
S
G
KY
-
L
AP
I
T
GN
N
YE
L
G
L
K
SDWM
N
S
RL
TT
T
L
A
I
FR
IEQD
N
VAQ
STGTPIPG
S
N
G
E
T
A
Y
KA
V
--
D
GT
V
S
KGVE
F
E
LN
---
GAIT
D
N
WQ
L
T
F
G
A
T
RYI
AE
DNEG
N
AV
N
P
N
--
--
--------
L
P
R
T
TVK
MF
T
S
Y
RLP
V
M
P
--
E
LTVG
G
G
V
NW
Q
N
---
R
VYTDT
V
-
T
P
Y
GT
FR
A
EQ
GSY
A
L
VD
L
FT
RY
Q
V
T
K
----
N
F
S
L
Q
G
NVNNLFD
KT
Y
DTN
VEG
S
I
V
-------
---Y
GAPR
N
F
SI
T
G
T
YQ
F
fig|679204.3.peg.3643
Escherichia coli MS 145-7 (21-729/729)
L
AG
CIA
L
ALLP
SA
A
F
AA
P
AT-
--
E
E
T
V
I
VE
G
S
A
---
T
AP
D
D
GE
----
NDYSVTSTSA
GTK
MQM
T
QR
D
I
PQS
V
T
I
VS
Q
Q
R
M
E
DQQ
LQ
T
L
G
E
VM
E
NT
Q
G
I
S
---
-
-
-K
S
Q
A
D
S
D
R
A
LY
Y
S
RGF
-
----
Q
ID
N
Y
M
V
DGI
PT
YFESRWN
L
G
D
----
A
LS
D
MALF
ERVEV
V
RG
A
T
G
LM
T
G
T
G
N
P
S
A
A
INMV
R
K
H
A
T
S
REF
K
G
DVSA
EY
GS
WNKE
R
YVA
D
LQSP
L
T
E
DG
KI
R
A
R
I
V
G
GY
Q
N
N
D
S
WL
D
RYNS
E
KT
FF
SG
IVD
A
D
LG
DLTM
L
SAG
----------
-
-
--Y
E
Y
QRI
D
VNS
PT
W
G
--
-
-G
LP
RW
N
T
DG--
--
S
S
NS
Y
D
RARSTAP
D
W
A
YND
KEI
N
KVF
M
T
--------
L
K
Q
R
F
A
DT
W
Q
A
T
L
N
A
T
H
SEV
E
F
D
S
--
KM
MY
V
D
AY
VNKA
D
GMLVG
P
YS
NYGPGFDY
VGGTGWNSGKRKVD
A
LDLFA
D
GSY
E
L
F
GR
Q
-
-
-
-
-
-
-
-
--
-
-
-
H
N
L
M
---------------
F
G
G
S
Y
S
K
QN
N
RYF
S
S
--------------------
W
A
--
---
-
---
-
--
N
IF-
PD
E
IGSFYNFNG
N
FP
Q
TDWSPQSL
A
QDD
T
T
HMKS
LYA
A
T
RV
T
LADP
L
H
L
I
L
G
A
R
YT
N
W
--
R
V
D
T
L
T
Y
------------
---------
-
-
-----
SMEK
N
HT
T
P
Y
AG
LV
F
D
I
N
DN
W
-
S
T
Y
A
SY
T
S
I
FQ
-----
P
---------
-
Q
NDR
---
D
S
S
G
KY
-
L
AP
I
T
GN
N
YE
L
G
L
K
SDWM
N
S
RL
TT
T
L
A
I
FR
IEQD
N
VAQ
STGTPIPG
S
N
G
E
T
A
Y
KA
V
--
D
GT
V
S
KGVE
F
E
LN
---
GAIT
D
N
WQ
L
T
F
G
A
T
RYI
AE
DNEG
N
AV
N
P
N
--
--
--------
L
P
R
T
TVK
MF
T
S
Y
RLP
V
M
P
--
E
LTVG
G
G
V
NW
Q
N
---
R
VYTDT
V
-
T
P
Y
GT
FR
A
EQ
GSY
A
L
VD
L
FT
RY
Q
V
T
K
----
N
F
S
L
Q
G
NVNNLFD
KT
Y
DTN
VEG
S
I
V
-------
---Y
GAPR
N
F
SI
T
G
T
YQ
F
fig|670888.3.peg.1729
Escherichia coli 1827-70 (21-729/729)
L
AG
CIA
L
ALLP
SA
A
F
AA
P
AT-
--
E
E
T
V
I
VE
G
S
A
---
T
AP
D
D
GE
----
NDYSVTSTSA
GTK
MQM
T
QR
D
I
PQS
V
T
I
VS
Q
Q
R
M
E
DQQ
LQ
T
L
G
E
VM
E
NT
L
G
I
S
---
-
-
-K
S
Q
A
D
S
D
R
A
LY
Y
S
RGF
-
----
Q
ID
N
Y
M
V
DGI
PT
YFESRWN
L
G
D
----
A
LS
D
MALF
ERVEV
V
RG
A
T
G
LM
T
G
T
G
N
P
S
A
A
INMV
R
K
H
A
T
S
REF
K
G
DVSA
EY
GS
WNKE
R
YVA
D
LQSP
L
T
E
DG
KI
R
A
R
I
V
G
GY
Q
N
N
D
S
WL
D
RYNS
E
KT
FF
SG
IVD
A
D
LG
DLTT
L
SAG
----------
-
-
--Y
E
Y
QRN
D
VNS
PT
W
G
--
-
-G
LP
RW
N
T
DG--
--
S
S
NS
Y
D
RARSTAP
D
W
A
YND
KEI
N
KVF
M
T
--------
L
K
Q
R
F
A
DT
W
Q
A
T
L
N
A
T
H
SEV
E
F
D
S
--
KM
MY
V
D
AY
VNKA
D
GMLVG
P
YS
NY
A
PGFDY
VGGTGWNSGKRKVD
A
LDLFA
D
GSY
E
L
F
GR
Q
-
-
-
-
-
-
-
-
--
-
-
-
H
N
L
M
---------------
F
G
G
S
Y
S
K
QN
N
RYF
S
S
--------------------
W
A
--
---
-
---
-
--
N
IF-
PD
E
IGSFYNFNG
N
FP
Q
TDWSPQSL
A
QDD
T
T
HMKS
LYA
A
T
RV
T
LADP
L
H
L
I
L
G
A
R
YT
N
W
--
R
V
D
T
L
T
Y
------------
---------
-
-
-----
SMEK
N
HT
T
P
Y
AG
LV
F
D
I
N
DN
W
-
S
T
Y
A
SY
T
S
I
FQ
-----
P
---------
-
Q
NDR
---
D
S
S
G
KY
-
L
AP
I
T
GN
N
YE
L
G
L
K
SDWM
N
S
RL
TT
T
L
A
I
FR
IEQD
N
VAQ
STGTPIPG
S
N
G
E
T
A
Y
KA
V
--
D
GT
V
S
KGVE
F
E
LN
---
GAIT
D
N
WQ
L
T
F
G
A
T
RYI
AE
DNEG
N
AV
N
P
N
--
--
--------
L
P
R
T
TVK
MF
T
S
Y
RLP
V
M
P
--
E
LTVG
G
G
V
NW
Q
N
---
R
VYTNT
V
-
T
P
Y
GT
FR
A
EQ
GSY
A
L
VD
L
FT
RY
Q
V
T
K
----
N
F
S
L
Q
G
NVNNLFD
KT
Y
DTN
VEG
S
I
V
-------
---Y
G
T
PR
N
F
SI
T
S
T
YQ
F
fig|679207.4.peg.1816
Escherichia coli MS 107-1 (21-729/729)
L
AG
CIA
L
ALLP
SA
A
F
AA
P
AT-
--
E
E
T
V
I
VE
G
S
A
---
T
AP
D
D
GE
----
NDYSVTSTSA
GTK
MQM
T
QR
D
I
PQS
V
T
I
VS
Q
Q
R
M
E
DQQ
LQ
T
L
G
E
VM
E
NT
Q
G
I
S
---
-
-
-K
S
Q
A
D
S
D
R
A
LY
Y
S
RGF
-
----
Q
ID
N
Y
M
V
DGI
PT
YFESRWN
L
G
D
----
A
LS
D
MALF
ERVEV
V
RG
A
T
G
LM
T
G
T
G
N
P
S
A
A
INMV
R
K
H
A
T
S
REF
K
G
DVSA
EY
GS
WNKE
R
YVA
D
LQSP
L
T
E
DG
KI
R
A
R
I
V
G
GY
Q
N
N
D
S
WL
D
RYNS
E
KT
FF
SG
IVD
A
D
LG
DLTT
L
SAG
----------
-
-
--Y
E
Y
QRI
D
VNS
PT
W
G
--
-
-G
LP
RW
N
T
DG--
--
S
S
NS
Y
D
RARSTAP
D
W
A
YND
KEI
N
KVF
M
T
--------
L
K
Q
R
F
A
DT
W
Q
A
T
L
N
A
T
H
SEV
E
F
D
S
--
KM
MY
V
D
AY
VNKA
D
GMLVG
P
YS
NYGPGFDY
VGGTGWNSGKRKVD
A
LDLFA
D
GSY
E
L
F
GR
Q
-
-
-
-
-
-
-
-
--
-
-
-
H
N
L
M
---------------
F
G
G
S
Y
S
K
QN
N
RYF
S
S
--------------------
W
T
--
---
-
---
-
--
N
IF-
PD
E
IGSFYNFNG
N
FP
Q
TDWSPQSL
A
QDD
T
T
HMKS
LYA
A
T
RV
T
LADP
L
H
L
I
L
G
A
R
YT
N
W
--
R
V
D
T
L
T
Y
------------
---------
-
-
-----
SMEK
N
HT
T
P
Y
AG
LV
F
D
I
N
DN
W
-
S
T
Y
A
SY
T
S
I
FQ
-----
P
---------
-
Q
NDR
---
D
S
S
G
KY
-
L
AP
I
T
GN
N
YE
L
G
L
K
SDWM
N
S
RL
TT
T
L
A
I
FR
IEQD
N
VAQ
STGTPIPG
S
N
G
E
T
A
Y
KA
V
--
D
GT
V
S
KGVE
F
E
LN
---
GAIT
D
N
WQ
L
T
F
G
A
T
RYI
AE
DNEG
N
AV
N
P
N
--
--
--------
L
P
R
T
TVK
MF
T
S
Y
RLP
V
M
P
--
E
LTVG
G
G
V
NW
Q
N
---
R
VYTDT
V
-
T
P
Y
GT
FR
A
EQ
GSY
A
L
VD
L
FT
RY
Q
V
T
K
----
N
F
S
L
Q
G
NVNNLFD
KT
Y
DTN
VEG
S
I
V
-------
---Y
GAPR
N
F
SI
T
G
T
YQ
F
fig|595495.4.peg.1833
Escherichia coli KO11 (21-729/729)
L
AG
CIA
L
ALLP
SA
A
F
AA
P
AT-
--
E
E
T
V
I
VE
G
S
A
---
T
AP
D
D
GE
----
NDYSVTSTSA
GTK
MQM
T
QR
D
I
PQS
V
T
I
VS
Q
Q
R
M
E
DQQ
LQ
T
L
G
E
VM
E
NT
Q
G
I
S
---
-
-
-K
S
Q
A
D
S
D
R
A
LY
Y
S
RGF
-
----
Q
ID
N
Y
M
V
DGI
PT
YFESRWN
L
G
D
----
A
LS
D
MALF
ERVEV
V
RG
A
T
G
LM
T
G
T
G
N
P
S
A
A
INMV
R
K
H
A
T
S
REF
K
G
DVSA
EY
GS
WNKE
R
YVA
D
LQSP
L
T
E
DG
KI
R
A
R
I
V
G
GY
Q
N
N
D
S
WL
D
RYNS
E
KT
FF
SG
IVD
A
D
LG
DLTT
L
SAG
----------
-
-
--Y
E
Y
QRI
D
VNS
PT
W
G
--
-
-G
LP
RW
N
T
DG--
--
S
S
NS
Y
D
RARSTAP
D
W
A
YND
KEI
N
KVF
M
T
--------
L
K
Q
R
F
A
DT
W
Q
A
T
L
N
A
T
H
SEV
E
F
D
S
--
KM
MY
V
D
AY
VNKA
D
GMLVG
P
YS
NYGPGFDY
VGGTGWNSGKRKVD
A
LDLFA
D
GSY
E
L
F
GR
Q
-
-
-
-
-
-
-
-
--
-
-
-
H
N
L
M
---------------
F
G
G
S
Y
S
K
QN
N
RYF
S
S
--------------------
W
A
--
---
-
---
-
--
N
IF-
PD
E
IGSFYNFNG
N
FP
Q
TDWSPQSL
A
QDD
T
T
HMKS
LYA
A
T
RV
T
LADP
L
H
L
I
L
G
A
R
YT
N
W
--
R
V
D
T
L
T
Y
------------
---------
-
-
-----
SMEK
N
HT
T
P
Y
AG
LV
F
D
I
N
DN
W
-
S
T
Y
A
SY
T
S
I
FQ
-----
P
---------
-
Q
NDR
---
D
S
S
G
KY
-
L
AP
I
T
GN
N
YE
L
G
L
K
SDWM
N
S
RL
TT
T
L
A
I
FR
IEQD
N
VAQ
STGTPIPG
S
N
G
E
T
A
Y
KA
V
--
D
GT
V
S
KGVE
F
E
LN
---
GAIT
D
N
WQ
L
T
F
G
A
T
RYI
AE
DNEG
N
AV
N
P
N
--
--
--------
L
P
R
T
TVK
MF
T
S
Y
RLP
V
M
P
--
E
LTVG
G
G
V
NW
Q
N
---
R
VYTDT
V
-
T
P
Y
GT
FR
A
EQ
GSY
A
L
VD
L
FT
RY
Q
V
T
K
----
N
F
S
L
Q
G
NVNNLFD
KT
Y
DTN
VEG
S
I
V
-------
---Y
GAPR
N
F
SI
T
G
T
YQ
F
fig|679206.4.peg.890
Escherichia coli MS 119-7 (21-729/729)
L
AG
CIA
L
ALLP
SA
A
F
AA
P
AT-
--
E
E
T
V
I
VE
G
S
A
---
T
AP
D
D
GE
----
NDYSVTSTSA
GTK
MQM
T
QR
D
I
PQS
V
T
I
VS
Q
Q
R
M
E
DQQ
LQ
T
L
G
E
VM
E
NT
Q
G
I
S
---
-
-
-K
S
Q
A
D
S
D
R
A
LY
Y
S
RGF
-
----
Q
ID
N
Y
M
V
DGI
PT
YFESRWN
L
G
D
----
A
LS
D
MALF
ERVEV
V
RG
A
T
G
LM
T
G
T
G
N
P
S
A
A
INMV
R
K
H
A
T
S
REF
K
G
DVSA
EY
GS
WNKE
R
YVA
D
LQSP
L
T
E
DG
KI
R
A
R
I
V
G
GY
Q
N
N
D
S
WL
D
RYNS
E
KT
FF
SG
IVD
A
D
LG
DLTT
L
SAG
----------
-
-
--Y
E
Y
QRI
D
VNS
PT
W
G
--
-
-G
LP
RW
N
T
DG--
--
S
S
NS
Y
D
RARSTAP
D
W
A
YND
KEI
N
KVF
M
T
--------
L
K
Q
R
F
A
DT
W
Q
A
T
L
N
A
T
H
SEV
E
F
D
S
--
KM
MY
V
D
AY
VNKA
D
GMLVG
P
YS
NYGPGFDY
VGGTGWNSGKRKVD
A
LDLFA
D
GSY
E
L
F
GR
Q
-
-
-
-
-
-
-
-
--
-
-
-
H
N
L
M
---------------
F
G
G
S
Y
S
K
QN
N
RYF
S
S
--------------------
W
A
--
---
-
---
-
--
N
IF-
PD
E
IGSFYNFNG
N
FP
Q
TDWSPQSL
A
QDD
T
T
HMKS
LYA
A
T
RV
T
LADP
L
H
L
I
L
G
A
R
YT
N
W
--
R
V
D
T
L
T
Y
------------
---------
-
-
-----
SMEK
N
HT
T
P
Y
AG
LV
F
D
I
N
DN
W
-
S
T
Y
A
SY
T
S
I
FQ
-----
P
---------
-
Q
NDR
---
D
S
S
G
KY
-
L
AP
I
T
GN
N
YE
L
G
L
K
SDWM
N
S
RL
TT
T
L
A
I
FR
IEQD
N
VAQ
STGTPIPG
S
N
G
E
T
A
Y
KA
V
--
D
GT
V
S
KGVE
F
E
LN
---
GAIT
D
N
WQ
L
T
F
G
A
T
RYI
AE
DNEG
N
AV
N
P
N
--
--
--------
L
P
R
T
TVK
MF
T
S
Y
RLP
V
M
P
--
E
LTVG
G
G
V
NW
Q
N
---
R
VYTDT
V
-
T
P
Y
GT
FR
A
EQ
GSY
A
L
VD
L
FT
RY
Q
V
T
K
----
N
F
S
L
Q
G
NVNNLFD
KT
Y
DTN
VEG
S
I
V
-------
---Y
GAPR
N
F
SI
T
G
T
YQ
F
fig|749545.3.peg.819
Escherichia coli MS 182-1 (21-729/729)
L
AG
CIA
L
ALLP
SA
A
F
AA
P
AT-
--
E
E
T
V
I
VE
G
S
A
---
T
AP
D
D
GE
----
NDYSVTSTSA
GTK
MQM
T
QR
D
I
PQS
V
T
I
VS
Q
Q
R
M
E
DQQ
LQ
T
L
G
E
VM
E
NT
Q
G
I
S
---
-
-
-K
S
Q
A
D
S
D
R
A
LY
Y
S
RGF
-
----
Q
ID
N
Y
M
V
DGI
PT
YFESRWN
L
G
D
----
A
LS
D
MALF
ERVEV
V
RG
A
T
G
LM
T
G
T
G
N
P
S
A
A
INMV
R
K
H
A
T
S
REF
K
G
DVSA
EY
GS
WNKE
R
YVA
D
LQSP
L
T
E
DG
KI
R
A
R
I
V
G
GY
Q
N
N
D
S
WL
D
RYNS
E
KT
FF
SG
IVD
A
D
LG
DLTT
L
SAG
----------
-
-
--Y
E
Y
QRI
D
VNS
PT
W
G
--
-
-G
LP
RW
N
T
DG--
--
S
S
NS
Y
D
RARSTAP
D
W
A
YND
KEI
N
KVF
M
T
--------
L
K
Q
R
F
A
DT
W
Q
A
T
L
N
A
T
H
SEV
E
F
D
S
--
KM
MY
V
D
AY
VNKA
D
GMLVG
P
YS
NYGPGFDY
VGGTGWNSGKRKVD
A
LDLFA
D
GSY
E
L
F
GR
Q
-
-
-
-
-
-
-
-
--
-
-
-
H
N
L
M
---------------
F
G
G
S
Y
S
K
QN
N
RYF
S
S
--------------------
W
A
--
---
-
---
-
--
N
IF-
PD
E
IGSFYNFNG
N
FP
Q
TDWSPQSL
A
QDD
T
T
HMKS
LYA
A
T
RV
T
LADP
L
H
L
I
L
G
A
R
YT
N
W
--
R
V
D
T
L
T
Y
------------
---------
-
-
-----
SMEK
N
HT
T
P
Y
AG
LV
F
D
I
N
DN
W
-
S
T
Y
A
SY
T
S
I
FQ
-----
P
---------
-
Q
NDR
---
D
S
S
G
KY
-
L
AP
I
T
GN
N
YE
L
G
L
K
SDWM
N
S
RL
TT
T
L
A
I
FR
IEQD
N
VAQ
STGTPIPG
S
N
G
E
T
A
Y
KA
V
--
D
GT
V
S
KGVE
F
E
LN
---
GAIT
D
N
WQ
L
T
F
G
A
T
RYI
AE
DNEG
N
AV
N
P
N
--
--
--------
L
P
R
T
TVK
MF
T
S
Y
RLP
V
M
P
--
E
LTVG
G
G
V
NW
Q
N
---
R
VYTDT
V
-
T
P
Y
GT
FR
A
EQ
GSY
A
L
VD
L
FT
RY
Q
V
T
K
----
N
F
S
L
Q
G
NVNNLFD
KT
Y
DTN
VEG
S
I
V
-------
---Y
GAPR
N
F
SI
T
G
T
YQ
F
fig|749532.3.peg.3327
Escherichia coli MS 78-1 (21-729/729)
L
AG
CIA
L
ALLP
SA
A
F
AA
P
AT-
--
E
E
T
V
I
VE
G
S
A
---
T
AP
D
D
GE
----
NDYSVTSTSA
GTK
MQM
T
QR
D
I
PQS
V
T
I
VS
Q
Q
R
M
E
DQQ
LQ
T
L
G
E
VM
E
NT
Q
G
I
S
---
-
-
-K
S
Q
A
D
S
D
R
A
LY
Y
S
RGF
-
----
Q
ID
N
Y
M
V
DGI
PT
YFESRWN
L
G
D
----
A
LS
D
MALF
ERVEV
V
RG
A
T
G
LM
T
G
T
G
N
P
S
A
A
INMV
R
K
H
A
T
S
REF
K
G
DVSA
EY
GS
WNKE
R
YVA
D
LQSP
L
T
E
DG
KI
R
A
R
I
V
G
GY
Q
N
N
D
S
WL
D
RYNS
E
KT
FF
SG
IVD
A
D
LG
DLTT
L
SAG
----------
-
-
--Y
E
Y
QRI
D
VNS
PT
W
G
--
-
-G
LP
RW
N
T
DG--
--
S
S
NS
Y
D
RARSTAP
D
W
A
YND
KEI
N
KVF
M
T
--------
L
K
Q
R
F
A
DT
W
Q
A
T
L
N
A
T
H
SEV
E
F
D
S
--
KM
MY
V
D
AY
VNKA
D
GMLVG
P
YS
NYGPGFDY
VGGTGWNSGKRKVD
A
LDLFA
D
GSY
E
L
F
GR
Q
-
-
-
-
-
-
-
-
--
-
-
-
H
N
L
M
---------------
F
G
G
S
Y
S
K
QN
N
RYF
S
S
--------------------
W
A
--
---
-
---
-
--
N
IF-
PD
E
IGSFYNFNG
N
FP
Q
TDWSPQSL
A
QDD
T
T
HMKS
LYA
A
T
RV
T
LADP
L
H
L
I
L
G
A
R
YT
N
W
--
R
V
D
T
L
T
Y
------------
---------
-
-
-----
SMEK
N
HT
T
P
Y
AG
LV
F
D
I
N
DN
W
-
S
T
Y
A
SY
T
S
I
FQ
-----
P
---------
-
Q
NDR
---
D
S
S
G
KY
-
L
AP
I
T
GN
N
YE
L
G
L
K
SDWM
N
S
RL
TT
T
L
A
I
FR
IEQD
N
VAQ
STGTPIPG
S
N
G
E
T
A
Y
KA
V
--
D
GT
V
S
KGVE
F
E
LN
---
GAIT
D
N
WQ
L
T
F
G
A
T
RYI
AE
DNEG
N
AV
N
P
N
--
--
--------
L
P
R
T
TVK
MF
T
S
Y
RLP
V
M
P
--
E
LTVG
G
G
V
NW
Q
N
---
R
VYTDT
V
-
T
P
Y
GT
FR
A
EQ
GSY
A
L
VD
L
FT
RY
Q
V
T
K
----
N
F
S
L
Q
G
NVNNLFD
KT
Y
DTN
VEG
S
I
V
-------
---Y
GAPR
N
F
SI
T
G
T
YQ
F
fig|656443.3.peg.1433
Escherichia coli TA271 (21-729/729)
L
AG
CIA
L
ALLP
SA
A
F
AA
P
AT-
--
E
E
T
V
I
VE
G
S
A
---
T
AP
D
D
GE
----
NDYSVTSTSA
GTK
MQM
T
QR
D
I
PQS
V
T
I
VS
Q
Q
R
M
E
DQQ
LQ
T
L
G
E
VM
E
NT
Q
G
I
S
---
-
-
-K
S
Q
A
D
S
D
R
A
LY
Y
S
RGF
-
----
Q
ID
N
Y
M
V
DGI
PT
YFESRWN
L
G
D
----
A
LS
D
MALF
ERVEV
V
RG
A
T
G
LM
T
G
T
G
N
P
S
A
A
INMV
R
K
H
A
T
S
REF
K
G
DVSA
EY
GS
WNKE
R
YVA
D
LQSP
L
T
E
DG
KI
R
A
R
I
V
G
GY
Q
N
N
D
S
WL
D
RYNS
E
KT
FF
SG
IVD
A
D
LG
DLTT
L
SAG
----------
-
-
--Y
E
Y
QRI
D
VNS
PT
W
G
--
-
-G
LP
RW
N
T
DG--
--
S
S
NS
Y
D
RARSTAP
D
W
A
YND
KEI
N
KVF
M
T
--------
L
K
Q
R
F
A
DT
W
Q
A
T
L
N
A
T
H
SEV
E
F
D
S
--
KM
MY
V
D
AY
VNKA
D
GMLVG
P
YS
NYGPGFDY
VGGTGWNSGKRKVD
A
LDLFA
D
GSY
E
L
F
GR
Q
-
-
-
-
-
-
-
-
--
-
-
-
H
N
L
M
---------------
F
G
G
S
Y
S
K
QN
N
RYF
S
S
--------------------
W
A
--
---
-
---
-
--
N
IF-
PD
E
IGSFYNFNG
N
FP
Q
TDWSPQSL
A
QDD
T
T
HMKS
LYA
A
T
RV
T
LADP
L
H
L
I
L
G
A
R
YT
N
W
--
R
V
D
T
L
T
Y
------------
---------
-
-
-----
SMEK
N
HT
T
P
Y
AG
LV
F
D
I
N
DN
W
-
S
T
Y
A
SY
T
S
I
FQ
-----
P
---------
-
Q
NDR
---
D
S
S
G
KY
-
L
AP
I
T
GN
N
YE
L
G
L
K
SDWM
N
S
RL
TT
T
L
A
I
FR
IEQD
N
VAQ
STGTPIPG
S
N
G
E
T
A
Y
KA
V
--
D
GT
V
S
KGVE
F
E
LN
---
GAIT
D
N
WQ
L
T
F
G
A
T
RYI
AE
DNEG
N
AV
N
P
N
--
--
--------
L
P
R
T
TVK
MF
T
S
Y
RLP
V
M
P
--
E
LTVG
G
G
V
NW
Q
N
---
R
VYTDT
V
-
T
P
Y
GT
FR
A
EQ
GSY
A
L
VD
L
FT
RY
Q
V
T
K
----
N
F
S
L
Q
G
NVNNLFD
KT
Y
DTN
VEG
S
I
V
-------
---Y
GAPR
N
F
SI
T
G
T
YQ
F
fig|566546.3.peg.394
Escherichia coli W (21-729/729)
L
AG
CIA
L
ALLP
SA
A
F
AA
P
AT-
--
E
E
T
V
I
VE
G
S
A
---
T
AP
D
D
GE
----
NDYSVTSTSA
GTK
MQM
T
QR
D
I
PQS
V
T
I
VS
Q
Q
R
M
E
DQQ
LQ
T
L
G
E
VM
E
NT
Q
G
I
S
---
-
-
-K
S
Q
A
D
S
D
R
A
LY
Y
S
RGF
-
----
Q
ID
N
Y
M
V
DGI
PT
YFESRWN
L
G
D
----
A
LS
D
MALF
ERVEV
V
RG
A
T
G
LM
T
G
T
G
N
P
S
A
A
INMV
R
K
H
A
T
S
REF
K
G
DVSA
EY
GS
WNKE
R
YVA
D
LQSP
L
T
E
DG
KI
R
A
R
I
V
G
GY
Q
N
N
D
S
WL
D
RYNS
E
KT
FF
SG
IVD
A
D
LG
DLTT
L
SAG
----------
-
-
--Y
E
Y
QRI
D
VNS
PT
W
G
--
-
-G
LP
RW
N
T
DG--
--
S
S
NS
Y
D
RARSTAP
D
W
A
YND
KEI
N
KVF
M
T
--------
L
K
Q
R
F
A
DT
W
Q
A
T
L
N
A
T
H
SEV
E
F
D
S
--
KM
MY
V
D
AY
VNKA
D
GMLVG
P
YS
NYGPGFDY
VGGTGWNSGKRKVD
A
LDLFA
D
GSY
E
L
F
GR
Q
-
-
-
-
-
-
-
-
--
-
-
-
H
N
L
M
---------------
F
G
G
S
Y
S
K
QN
N
RYF
S
S
--------------------
W
A
--
---
-
---
-
--
N
IF-
PD
E
IGSFYNFNG
N
FP
Q
TDWSPQSL
A
QDD
T
T
HMKS
LYA
A
T
RV
T
LADP
L
H
L
I
L
G
A
R
YT
N
W
--
R
V
D
T
L
T
Y
------------
---------
-
-
-----
SMEK
N
HT
T
P
Y
AG
LV
F
D
I
N
DN
W
-
S
T
Y
A
SY
T
S
I
FQ
-----
P
---------
-
Q
NDR
---
D
S
S
G
KY
-
L
AP
I
T
GN
N
YE
L
G
L
K
SDWM
N
S
RL
TT
T
L
A
I
FR
IEQD
N
VAQ
STGTPIPG
S
N
G
E
T
A
Y
KA
V
--
D
GT
V
S
KGVE
F
E
LN
---
GAIT
D
N
WQ
L
T
F
G
A
T
RYI
AE
DNEG
N
AV
N
P
N
--
--
--------
L
P
R
T
TVK
MF
T
S
Y
RLP
V
M
P
--
E
LTVG
G
G
V
NW
Q
N
---
R
VYTDT
V
-
T
P
Y
GT
FR
A
EQ
GSY
A
L
VD
L
FT
RY
Q
V
T
K
----
N
F
S
L
Q
G
NVNNLFD
KT
Y
DTN
VEG
S
I
V
-------
---Y
GAPR
N
F
SI
T
G
T
YQ
F
fig|566546.4.peg.1205
Escherichia coli W (21-729/729)
L
AG
CIA
L
ALLP
SA
A
F
AA
P
AT-
--
E
E
T
V
I
VE
G
S
A
---
T
AP
D
D
GE
----
NDYSVTSTSA
GTK
MQM
T
QR
D
I
PQS
V
T
I
VS
Q
Q
R
M
E
DQQ
LQ
T
L
G
E
VM
E
NT
Q
G
I
S
---
-
-
-K
S
Q
A
D
S
D
R
A
LY
Y
S
RGF
-
----
Q
ID
N
Y
M
V
DGI
PT
YFESRWN
L
G
D
----
A
LS
D
MALF
ERVEV
V
RG
A
T
G
LM
T
G
T
G
N
P
S
A
A
INMV
R
K
H
A
T
S
REF
K
G
DVSA
EY
GS
WNKE
R
YVA
D
LQSP
L
T
E
DG
KI
R
A
R
I
V
G
GY
Q
N
N
D
S
WL
D
RYNS
E
KT
FF
SG
IVD
A
D
LG
DLTT
L
SAG
----------
-
-
--Y
E
Y
QRI
D
VNS
PT
W
G
--
-
-G
LP
RW
N
T
DG--
--
S
S
NS
Y
D
RARSTAP
D
W
A
YND
KEI
N
KVF
M
T
--------
L
K
Q
R
F
A
DT
W
Q
A
T
L
N
A
T
H
SEV
E
F
D
S
--
KM
MY
V
D
AY
VNKA
D
GMLVG
P
YS
NYGPGFDY
VGGTGWNSGKRKVD
A
LDLFA
D
GSY
E
L
F
GR
Q
-
-
-
-
-
-
-
-
--
-
-
-
H
N
L
M
---------------
F
G
G
S
Y
S
K
QN
N
RYF
S
S
--------------------
W
A
--
---
-
---
-
--
N
IF-
PD
E
IGSFYNFNG
N
FP
Q
TDWSPQSL
A
QDD
T
T
HMKS
LYA
A
T
RV
T
LADP
L
H
L
I
L
G
A
R
YT
N
W
--
R
V
D
T
L
T
Y
------------
---------
-
-
-----
SMEK
N
HT
T
P
Y
AG
LV
F
D
I
N
DN
W
-
S
T
Y
A
SY
T
S
I
FQ
-----
P
---------
-
Q
NDR
---
D
S
S
G
KY
-
L
AP
I
T
GN
N
YE
L
G
L
K
SDWM
N
S
RL
TT
T
L
A
I
FR
IEQD
N
VAQ
STGTPIPG
S
N
G
E
T
A
Y
KA
V
--
D
GT
V
S
KGVE
F
E
LN
---
GAIT
D
N
WQ
L
T
F
G
A
T
RYI
AE
DNEG
N
AV
N
P
N
--
--
--------
L
P
R
T
TVK
MF
T
S
Y
RLP
V
M
P
--
E
LTVG
G
G
V
NW
Q
N
---
R
VYTDT
V
-
T
P
Y
GT
FR
A
EQ
GSY
A
L
VD
L
FT
RY
Q
V
T
K
----
N
F
S
L
Q
G
NVNNLFD
KT
Y
DTN
VEG
S
I
V
-------
---Y
GAPR
N
F
SI
T
G
T
YQ
F
fig|656417.3.peg.1341
Escherichia coli M605 (21-729/729)
L
AG
CIA
L
ALLP
SA
A
F
AA
P
AT-
--
E
E
T
V
I
VE
G
S
A
---
T
AP
D
D
GE
----
NDYNVTSTSA
GTK
MQM
T
QR
D
I
PQS
V
T
I
VS
Q
Q
R
M
E
DQQ
LQ
T
L
G
E
VM
E
NT
L
G
I
S
---
-
-
-K
S
Q
A
D
S
D
R
A
LY
Y
S
RGF
-
----
Q
ID
N
Y
M
V
DGI
PT
YFESRWN
L
G
D
----
A
LS
D
MALF
ERVEV
V
RG
A
T
G
LM
T
G
T
G
N
P
S
A
A
INMV
R
K
H
A
T
S
REF
K
G
DVSA
EY
GS
WNKE
R
YVA
D
LQSP
L
T
E
DG
KI
R
A
R
I
V
G
GY
Q
N
N
D
S
WL
D
RYNS
E
KT
FF
SG
IVD
A
D
LG
DLTM
L
SAG
----------
-
-
--Y
E
Y
QRI
D
VNS
PT
W
G
--
-
-G
LP
RW
N
T
DG--
--
S
S
NS
Y
D
RARSTAP
D
W
A
YND
KEI
N
KVF
M
T
--------
L
K
Q
R
F
A
DT
W
Q
A
T
L
N
A
T
H
SEV
E
F
D
S
--
KM
MY
V
D
AY
VNKA
D
GMLVG
P
YS
NYGPGFDY
VGGTGWNSGKRKVD
A
LDLFA
D
GSY
E
L
F
GR
Q
-
-
-
-
-
-
-
-
--
-
-
-
H
N
L
M
---------------
F
G
G
S
Y
S
K
QN
N
RYF
S
S
--------------------
W
A
--
---
-
---
-
--
N
IF-
PD
E
IGSFYNFNG
N
FP
Q
TDRSPQSL
A
QDD
T
T
HMKS
LYA
A
T
RV
T
LADP
L
H
L
I
L
G
A
R
YT
N
W
--
R
V
D
T
L
T
Y
------------
---------
-
-
-----
SMEK
N
HT
T
P
Y
AG
LV
F
D
I
N
DN
W
-
S
T
Y
A
SY
T
S
I
FQ
-----
P
---------
-
Q
NDR
---
D
S
S
G
KY
-
L
AP
I
T
GN
N
YE
L
G
L
K
SDWM
N
S
RL
TT
T
L
A
I
FR
IEQD
N
VAQ
STGTPIPG
S
N
G
E
T
A
Y
KA
V
--
D
GT
V
S
KGVE
F
E
LN
---
GAIT
D
N
WQ
L
T
F
G
A
T
RYI
AE
DNEG
N
AV
N
P
N
--
--
--------
L
P
R
T
TVK
MF
T
S
Y
RLP
V
M
P
--
E
LTVG
G
G
V
NW
Q
N
---
R
VYTDT
V
-
T
P
Y
GT
FR
A
EQ
GSY
A
L
VD
L
FT
RY
Q
V
T
K
----
N
F
S
L
Q
G
NVNNLFD
KT
Y
DTN
VEG
S
I
V
-------
---Y
GAPR
N
L
SI
T
G
T
YQ
F
fig|409438.11.peg.1301
Escherichia coli SE11 (14-729/729)
ASTKP
S
L
L
AG
CIA
L
ALLP
SA
A
F
AA
P
AT-
--
E
E
T
V
I
VE
G
S
A
---
T
AP
D
D
GE
----
NDYSVTSTSA
GTK
MQM
T
QR
D
I
PQS
V
T
I
VS
Q
Q
R
M
E
DQQ
LQ
T
L
G
E
VM
E
NT
L
G
I
S
---
-
-
-K
S
Q
A
D
S
D
R
A
LY
Y
S
RGF
-
----
Q
ID
N
Y
M
V
DGI
PT
YFESRWN
L
G
D
----
A
LS
D
MALF
ERVEV
V
RG
A
T
G
LM
T
G
T
G
N
P
S
A
A
INMV
R
K
H
A
T
S
REF
K
G
DVSA
EY
GS
WNKE
R
YVA
D
LQSP
L
T
E
DG
KI
R
A
R
I
V
G
GY
Q
N
N
D
S
WL
D
RYNS
E
KT
FF
SG
IVD
A
D
LG
DLTT
L
SAG
----------
-
-
--Y
E
Y
QRI
D
VNS
PT
W
G
--
-
-G
LP
RW
N
T
DG--
--
S
S
NS
Y
D
RARSTAP
D
W
A
YND
KEI
N
KVF
M
T
--------
L
K
Q
R
F
A
DT
W
Q
A
T
L
N
A
T
H
SEV
E
F
D
S
--
KM
MY
V
D
AY
VNKA
D
GMLVG
P
YS
NYGPGFDY
VGGTGWNSGKRKVD
A
LDLFA
D
GSY
E
L
F
GR
Q
-
-
-
-
-
-
-
-
--
-
-
-
H
N
L
M
---------------
F
G
G
S
Y
S
K
QN
N
RYF
S
S
--------------------
W
A
--
---
-
---
-
--
N
IF-
PD
E
IGSFYNFNG
N
FP
Q
TDWSPQSL
A
QDD
T
T
HMKS
LYA
A
T
RV
T
LADP
L
H
L
I
L
G
A
R
YT
N
W
--
R
V
D
T
L
T
Y
------------
---------
-
-
-----
SMEK
N
HT
T
P
Y
AG
LV
F
D
I
N
DN
W
-
S
T
Y
A
SY
T
S
I
FQ
-----
P
---------
-
Q
NDR
---
D
S
S
G
KY
-
L
AP
I
T
GN
N
YE
L
G
L
K
SDWM
N
S
RL
TT
T
L
A
I
FR
IEQD
N
VAQ
STGTPIPG
S
N
G
E
T
A
Y
KA
V
--
D
GT
V
S
KGVE
F
E
LN
---
GAIT
D
N
WQ
L
T
F
G
A
T
RYI
AE
DNEG
N
AV
N
P
N
--
--
--------
L
P
R
T
TVK
MF
T
S
Y
RLP
V
M
P
--
E
LTVG
G
G
V
NW
Q
N
---
R
VYTDT
V
-
T
P
Y
GT
FR
A
EQ
GSY
A
L
VD
L
FT
RY
Q
V
T
K
----
N
F
S
L
Q
G
NVNNLFD
KT
Y
DTN
VEG
S
I
V
-------
---Y
GAPR
N
F
SI
T
G
T
YQ
F
fig|656408.3.peg.1177
Escherichia coli H591 (21-729/729)
L
AG
CIA
L
ALLP
SA
A
F
AA
P
AT-
--
E
E
T
V
I
VE
G
S
A
---
T
AP
D
D
GE
----
NDYSVTSTSA
GTK
MQM
T
QR
D
I
PQS
V
T
I
VS
Q
Q
R
M
E
DQQ
LQ
T
L
G
E
VM
E
NT
Q
G
I
S
---
-
-
-K
S
Q
A
D
S
D
R
A
LY
Y
S
RGF
-
----
Q
ID
N
Y
M
V
DGI
PT
YFESRWN
L
G
D
----
A
LS
D
MALF
ERVEV
V
RG
A
T
G
LM
T
G
T
G
N
P
S
A
A
INMV
R
K
H
A
T
S
REF
K
G
DVSA
EY
GS
WNKE
R
YVA
D
LQSP
L
T
E
DG
KI
R
A
R
I
V
G
GY
Q
N
N
D
S
WL
D
RYNS
E
KT
FF
SG
IVD
A
D
LG
DLTT
L
SAG
----------
-
-
--Y
E
Y
QRI
D
VNS
PT
W
G
--
-
-G
LP
RW
N
T
DG--
--
S
S
NS
Y
D
RARSTAP
D
W
A
YND
KEI
N
KVF
M
T
--------
L
K
Q
R
F
A
DT
W
Q
A
T
L
N
A
T
H
SEV
E
F
D
S
--
KM
MY
V
D
AY
VNKA
D
GMLVG
P
YS
NYGPGFDY
VGGTGWNSGKRKVD
A
LDLFA
H
GSY
E
L
F
GR
Q
-
-
-
-
-
-
-
-
--
-
-
-
H
N
L
M
---------------
F
G
G
S
Y
S
K
QN
N
RYF
S
S
--------------------
W
A
--
---
-
---
-
--
N
IF-
PD
E
IGSFYNFNG
N
FP
Q
TDWSPQSL
A
QDD
T
T
HMKS
LYA
A
T
RV
T
LADP
L
H
L
I
L
G
A
R
YT
N
W
--
R
V
D
T
L
T
Y
------------
---------
-
-
-----
SMEK
N
HT
T
P
Y
AG
LV
F
D
I
N
DN
W
-
S
T
Y
A
SY
T
S
I
FQ
-----
P
---------
-
Q
NDR
---
D
S
S
G
KY
-
L
AP
I
T
GN
N
YE
L
G
L
K
SDWM
N
S
RL
TT
T
L
A
I
FR
IEQD
N
VAQ
STGTPIPG
S
N
G
E
T
A
Y
KA
V
--
D
GT
V
S
KGVE
F
E
LN
---
GAIT
D
N
WQ
L
T
F
G
A
T
RYI
AE
DNEG
N
AV
N
P
N
--
--
--------
L
P
R
T
TVK
MF
T
S
Y
RLP
V
M
P
--
E
LTVG
G
G
V
NW
Q
N
---
R
VYTDT
V
-
T
P
Y
GT
FR
A
EQ
GSY
A
L
VD
L
FT
RY
Q
V
T
K
----
N
F
S
L
Q
G
NVNNLFD
KT
Y
DTN
VEG
S
I
V
-------
---Y
GAPR
N
F
SI
T
G
T
YQ
F
fig|585396.4.peg.1436
Escherichia coli O111:H- str. 11128 (14-729/729)
ASTKP
S
L
L
AG
CIA
L
ALLP
SA
A
F
AA
P
AT-
--
E
E
T
V
I
VE
G
S
A
---
T
AP
D
D
GE
----
NDYSVTSTSA
GTK
MQM
T
QR
D
I
PQS
V
T
I
VS
Q
Q
R
M
E
DQQ
LQ
T
L
G
E
VM
E
NT
L
G
I
S
---
-
-
-K
S
Q
A
D
S
D
R
A
LY
Y
S
RGF
-
----
Q
ID
N
Y
M
V
DGI
PT
YFESRWN
L
G
D
----
A
LS
D
MALF
ERVEV
V
RG
A
T
G
LM
T
G
T
G
N
P
S
A
A
INMV
R
K
H
A
T
S
REF
K
G
DVSA
EY
GS
WNKE
R
YVA
D
LQSP
L
T
E
DG
KI
R
A
R
I
V
G
GY
Q
N
N
D
S
WL
D
RYNS
E
KT
FF
SG
IVD
A
D
LG
DLTT
L
SAG
----------
-
-
--Y
E
Y
QHI
D
VNS
PT
W
G
--
-
-G
LP
RW
N
T
DG--
--
S
S
NS
Y
D
RARSTAP
D
W
A
YND
KEI
N
KVF
M
T
--------
L
K
Q
R
F
A
DT
W
Q
A
T
L
N
A
T
H
SEV
E
F
D
S
--
KM
MY
V
D
AY
VNKA
D
GMLIG
P
YS
NYGPGFDY
VGGTGWNSGKRKVD
A
LDLFA
D
GSY
E
L
F
GR
Q
-
-
-
-
-
-
-
-
--
-
-
-
H
N
L
M
---------------
F
G
G
S
Y
S
K
QN
N
RYF
S
S
--------------------
W
A
--
---
-
---
-
--
N
IF-
PD
E
IGSFYNFNG
N
FP
Q
TDWSPQSL
A
QDD
T
T
HMKS
LYA
A
T
RV
T
LADP
L
H
L
I
L
G
A
R
YT
N
W
--
R
V
D
T
L
T
Y
------------
---------
-
-
-----
SMEK
N
HT
T
P
Y
AG
LV
F
D
I
N
DN
W
-
S
T
Y
A
SY
T
S
I
FQ
-----
P
---------
-
Q
NDR
---
D
S
S
G
KY
-
L
AP
I
T
GN
N
YE
L
G
L
K
SDWM
N
S
RL
TT
T
L
A
I
FR
IEQD
N
VAQ
STGTPIPG
S
N
G
E
T
A
Y
KA
V
--
D
GT
V
S
KGVE
F
E
LN
---
GAIT
D
N
WQ
L
T
F
G
A
T
RYI
AE
DNEG
N
AV
N
P
N
--
--
--------
L
P
R
T
TVK
MF
T
S
Y
RLP
V
M
P
--
E
LTVG
G
G
V
NW
K
N
---
R
VYTDT
V
-
T
P
Y
GT
FR
A
EQ
GSY
A
L
VD
L
FT
RY
Q
V
T
K
----
N
F
S
L
Q
G
NVNNLFD
KT
Y
DTN
VEG
S
I
V
-------
---Y
GAPR
N
F
SI
T
G
T
YQ
F
fig|573235.3.peg.1468
Escherichia coli O26:H11 str. 11368 (14-729/729)
ASTKP
S
L
L
AG
CIA
L
ALLP
SA
A
F
AA
P
AT-
--
E
E
T
V
I
VE
G
S
A
---
T
AP
D
D
GE
----
NDYSVTSTSA
GTK
MQM
T
QR
D
I
PQS
V
T
I
VS
Q
Q
R
M
E
DQQ
LQ
T
L
G
E
VM
E
NT
L
G
I
S
---
-
-
-K
S
Q
A
D
S
D
R
A
LY
Y
S
RGF
-
----
Q
ID
N
Y
M
V
DGI
PT
YFESRWN
L
G
D
----
A
LS
D
MALF
ERVEV
V
RG
A
T
G
LM
T
G
T
G
N
P
S
A
A
INMV
R
K
H
A
T
S
REF
K
G
DVSA
EY
GS
WNKE
R
YVA
D
LQSP
L
T
E
DG
KI
R
A
R
I
V
G
GY
Q
N
N
D
S
WL
D
RYNS
E
KT
FF
SG
IVD
A
D
LG
DLTT
L
SAG
----------
-
-
--Y
E
Y
QHI
D
VNS
PT
W
G
--
-
-G
LP
RW
N
T
DG--
--
S
S
NS
Y
D
RARSTAP
D
W
A
YND
KEI
N
KVF
M
T
--------
L
K
Q
R
F
A
DT
W
Q
A
T
L
N
A
T
H
SEV
E
F
D
S
--
KM
MY
V
D
AY
VNKA
D
GMLIG
P
YS
NYGPGFDY
VGGTGWNSGKRKVD
A
LDLFA
D
GSY
E
L
F
GR
Q
-
-
-
-
-
-
-
-
--
-
-
-
H
N
L
M
---------------
F
G
G
S
Y
S
K
QN
N
RYF
S
S
--------------------
W
A
--
---
-
---
-
--
N
IF-
PD
E
IGSFYNFNG
N
FP
Q
TDWSPQSL
A
QDD
T
T
HIKS
LYA
A
T
RV
T
LADP
L
H
L
I
L
G
A
R
YT
N
W
--
R
V
D
T
L
T
Y
------------
---------
-
-
-----
SMEK
N
HT
T
P
Y
AG
LV
F
D
I
N
DN
W
-
S
T
Y
A
SY
T
S
I
FQ
-----
P
---------
-
Q
NDR
---
D
S
S
G
KY
-
L
AP
I
T
GN
N
YE
L
G
L
K
SDWM
N
S
RL
TT
T
L
A
I
FR
IEQD
N
VAQ
STGTPIPG
S
N
G
E
T
A
Y
KA
V
--
D
GT
V
S
KGVE
F
E
LN
---
GAIT
D
N
WQ
L
T
F
G
A
T
RYI
AE
DNEG
N
AV
N
P
N
--
--
--------
L
P
R
T
TVK
MF
T
S
Y
RLP
V
M
P
--
E
LTVG
G
G
V
NW
Q
N
---
R
VYTDT
V
-
T
P
Y
GT
FR
A
EQ
GSY
A
L
VD
L
FT
RY
Q
V
T
K
----
N
F
S
L
Q
G
NVNNLFD
KT
Y
DTN
VEG
S
I
V
-------
---Y
GAPR
N
F
SI
T
G
T
YQ
F
fig|562.371.peg.4071
Escherichia coli 1044A (21-729/729)
L
AG
CIA
L
ALLP
SA
A
F
AA
P
AT-
--
E
E
T
V
I
VE
G
S
A
---
T
AP
D
D
GE
----
NDYSVTSTSA
GTK
MQM
T
QR
D
I
PQS
V
T
I
VS
Q
Q
R
M
E
DQQ
LQ
T
L
G
E
VM
E
NT
L
G
I
S
---
-
-
-K
S
Q
A
D
S
D
R
A
LY
Y
S
RGF
-
----
Q
ID
N
Y
M
V
DGI
PT
YFESRWN
L
G
D
----
A
LS
D
MALF
ERVEV
V
RG
A
T
G
LM
T
G
T
G
N
P
S
A
A
INMV
R
K
H
A
T
S
REF
K
G
DVSA
EY
GS
WNKE
R
YVA
D
LQSP
L
T
E
DG
KI
R
A
R
I
V
G
GY
Q
N
N
D
S
WL
D
RYNS
E
KT
FF
SG
IVD
A
D
LG
DLTT
L
SAG
----------
-
-
--Y
E
Y
QRI
D
VNS
PT
W
G
--
-
-G
LP
RW
N
T
DG--
--
S
S
NS
Y
D
RARSTAP
D
W
A
YND
KEI
N
KVF
M
T
--------
L
K
Q
R
F
A
DT
W
Q
A
T
L
N
A
T
H
SEV
E
F
D
S
--
KM
MY
V
D
AY
VNKA
D
GMLVG
P
YS
NYGPGFDY
VGGTGWNSGKRKVD
A
LDLFA
D
GSY
E
L
F
GR
Q
-
-
-
-
-
-
-
-
--
-
-
-
H
N
L
M
---------------
F
G
G
S
Y
S
K
QN
N
RYF
S
S
--------------------
W
A
--
---
-
---
-
--
N
IF-
PD
E
IGSFYNFNG
N
FP
Q
TDWSPQSL
A
QDD
T
T
HMKS
LYA
A
T
RV
T
LADP
L
H
L
I
L
G
A
R
YT
N
W
--
R
V
D
T
L
T
Y
------------
---------
-
-
-----
SMEK
N
HT
T
P
Y
AG
LV
F
D
I
N
DN
W
-
S
T
Y
A
SY
T
S
I
FQ
-----
P
---------
-
Q
NDR
---
D
S
S
G
KY
-
L
AP
I
T
GN
N
YE
L
G
L
K
SDWM
N
S
RL
TT
T
L
A
I
FR
IEQD
N
VAQ
STGTPIPG
S
N
G
E
T
A
Y
KA
V
--
D
GT
V
S
KGVE
F
E
LN
---
GAIT
D
N
WQ
L
T
F
G
A
T
RYI
AE
DNEG
N
AV
N
P
N
--
--
--------
L
P
R
T
TVK
MF
T
S
Y
RLP
V
M
P
--
E
LTVG
G
G
V
NW
Q
N
---
R
VYTDT
V
-
T
P
Y
GT
FR
A
EQ
GSY
A
L
VD
L
FT
RY
Q
V
T
K
----
N
F
S
L
Q
G
NVNNLFD
KT
Y
DTN
VEG
S
I
V
-------
---Y
GAPR
N
F
SI
T
G
T
YQ
F
fig|562.373.peg.4844
Escherichia coli 1125A (21-729/729)
L
AG
CIA
L
ALLP
SA
A
F
AA
P
AT-
--
E
E
T
V
I
VE
G
S
A
---
T
AP
D
D
GE
----
NDYSVTSTSA
GTK
MQM
T
QR
D
I
PQS
V
T
I
VS
Q
Q
R
M
E
DQQ
LQ
T
L
G
E
VM
E
NT
L
G
I
S
---
-
-
-K
S
Q
A
D
S
D
R
A
LY
Y
S
RGF
-
----
Q
ID
N
Y
M
V
DGI
PT
YFESRWN
L
G
D
----
A
LS
D
MALF
ERVEV
V
RG
A
T
G
LM
T
G
T
G
N
P
S
A
A
INMV
R
K
H
A
T
S
REF
K
G
DVSA
EY
GS
WNKE
R
YVA
D
LQSP
L
T
E
DG
KI
R
A
R
I
V
G
GY
Q
N
N
D
S
WL
D
RYNS
E
KT
FF
SG
IVD
A
D
LG
DLTT
L
SAG
----------
-
-
--Y
E
Y
QRI
D
VNS
PT
W
G
--
-
-G
LP
RW
N
T
DG--
--
S
S
NS
Y
D
RARSTAP
D
W
A
YND
KEI
N
KVF
M
T
--------
L
K
Q
R
F
A
DT
W
Q
A
T
L
N
A
T
H
SEV
E
F
D
S
--
KM
MY
V
D
AY
VNKA
D
GMLVG
P
YS
NYGPGFDY
VGGTGWNSGKRKVD
A
LDLFA
D
GSY
E
L
F
GR
Q
-
-
-
-
-
-
-
-
--
-
-
-
H
N
L
M
---------------
F
G
G
S
Y
S
K
QN
N
RYF
S
S
--------------------
W
A
--
---
-
---
-
--
N
IF-
PD
E
IGSFYNFNG
N
FP
Q
TDWSPQSL
A
QDD
T
T
HMKS
LYA
A
T
RV
T
LADP
L
H
L
I
L
G
A
R
YT
N
W
--
R
V
D
T
L
T
Y
------------
---------
-
-
-----
SMEK
N
HT
T
P
Y
AG
LV
F
D
I
N
DN
W
-
S
T
Y
A
SY
T
S
I
FQ
-----
P
---------
-
Q
NDR
---
D
S
S
G
KY
-
L
AP
I
T
GN
N
YE
L
G
L
K
SDWM
N
S
RL
TT
T
L
A
I
FR
IEQD
N
VAQ
STGTPIPG
S
N
G
E
T
A
Y
KA
V
--
D
GT
V
S
KGVE
F
E
LN
---
GAIT
D
N
WQ
L
T
F
G
A
T
RYI
AE
DNEG
N
AV
N
P
N
--
--
--------
L
P
R
T
TVK
MF
T
S
Y
RLP
V
M
P
--
E
LTVG
G
G
V
NW
Q
N
---
R
VYTDT
V
-
T
P
Y
GT
FR
A
EQ
GSY
A
L
VD
L
FT
RY
Q
V
T
K
----
N
F
S
L
Q
G
NVNNLFD
KT
Y
DTN
VEG
S
I
V
-------
---Y
GAPR
N
F
SI
T
G
T
YQ
F
fig|562.372.peg.562
Escherichia coli 1212A (21-729/729)
L
AG
CIA
L
ALLP
SA
A
F
AA
P
AT-
--
E
E
T
V
I
VE
G
S
A
---
T
AP
D
D
GE
----
NDYSVTSTSA
GTK
MQM
T
QR
D
I
PQS
V
T
I
VS
Q
Q
R
M
E
DQQ
LQ
T
L
G
E
VM
E
NT
L
G
I
S
---
-
-
-K
S
Q
A
D
S
D
R
A
LY
Y
S
RGF
-
----
Q
ID
N
Y
M
V
DGI
PT
YFESRWN
L
G
D
----
A
LS
D
MALF
ERVEV
V
RG
A
T
G
LM
T
G
T
G
N
P
S
A
A
INMV
R
K
H
A
T
S
REF
K
G
DVSA
EY
GS
WNKE
R
YVA
D
LQSP
L
T
E
DG
KI
R
A
R
I
V
G
GY
Q
N
N
D
S
WL
D
RYNS
E
KT
FF
SG
IVD
A
D
LG
DLTT
L
SAG
----------
-
-
--Y
E
Y
QRI
D
VNS
PT
W
G
--
-
-G
LP
RW
N
T
DG--
--
S
S
NS
Y
D
RARSTAP
D
W
A
YND
KEI
N
KVF
M
T
--------
L
K
Q
R
F
A
DT
W
Q
A
T
L
N
A
T
H
SEV
E
F
D
S
--
KM
MY
V
D
AY
VNKA
D
GMLVG
P
YS
NYGPGFDY
VGGTGWNSGKRKVD
A
LDLFA
D
GSY
E
L
F
GR
Q
-
-
-
-
-
-
-
-
--
-
-
-
H
N
L
M
---------------
F
G
G
S
Y
S
K
QN
N
RYF
S
S
--------------------
W
A
--
---
-
---
-
--
N
IF-
PD
E
IGSFYNFNG
N
FP
Q
TDWSPQSL
A
QDD
T
T
HMKS
LYA
A
T
RV
T
LADP
L
H
L
I
L
G
A
R
YT
N
W
--
R
V
D
T
L
T
Y
------------
---------
-
-
-----
SMEK
N
HT
T
P
Y
AG
LV
F
D
I
N
DN
W
-
S
T
Y
A
SY
T
S
I
FQ
-----
P
---------
-
Q
NDR
---
D
S
S
G
KY
-
L
AP
I
T
GN
N
YE
L
G
L
K
SDWM
N
S
RL
TT
T
L
A
I
FR
IEQD
N
VAQ
STGTPIPG
S
N
G
E
T
A
Y
KA
V
--
D
GT
V
S
KGVE
F
E
LN
---
GAIT
D
N
WQ
L
T
F
G
A
T
RYI
AE
DNEG
N
AV
N
P
N
--
--
--------
L
P
R
T
TVK
MF
T
S
Y
RLP
V
M
P
--
E
LTVG
G
G
V
NW
Q
N
---
R
VYTDT
V
-
T
P
Y
GT
FR
A
EQ
GSY
A
L
VD
L
FT
RY
Q
V
T
K
----
N
F
S
L
Q
G
NVNNLFD
KT
Y
DTN
VEG
S
I
V
-------
---Y
GAPR
N
F
SI
T
G
T
YQ
F
fig|562.374.peg.1605
Escherichia coli 536A (21-729/729)
L
AG
CIA
L
ALLP
SA
A
F
AA
P
AT-
--
E
E
T
V
I
VE
G
S
A
---
T
AP
D
D
GE
----
NDYSVTSTSA
GTK
MQM
T
QR
D
I
PQS
V
T
I
VS
Q
Q
R
M
E
DQQ
LQ
T
L
G
E
VM
E
NT
L
G
I
S
---
-
-
-K
S
Q
A
D
S
D
R
A
LY
Y
S
RGF
-
----
Q
ID
N
Y
M
V
DGI
PT
YFESRWN
L
G
D
----
A
LS
D
MALF
ERVEV
V
RG
A
T
G
LM
T
G
T
G
N
P
S
A
A
INMV
R
K
H
A
T
S
REF
K
G
DVSA
EY
GS
WNKE
R
YVA
D
LQSP
L
T
E
DG
KI
R
A
R
I
V
G
GY
Q
N
N
D
S
WL
D
RYNS
E
KT
FF
SG
IVD
A
D
LG
DLTT
L
SAG
----------
-
-
--Y
E
Y
QRI
D
VNS
PT
W
G
--
-
-G
LP
RW
N
T
DG--
--
S
S
NS
Y
D
RARSTAP
D
W
A
YND
KEI
N
KVF
M
T
--------
L
K
Q
R
F
A
DT
W
Q
A
T
L
N
A
T
H
SEV
E
F
D
S
--
KM
MY
V
D
AY
VNKA
D
GMLVG
P
YS
NYGPGFDY
VGGTGWNSGKRKVD
A
LDLFA
D
GSY
E
L
F
GR
Q
-
-
-
-
-
-
-
-
--
-
-
-
H
N
L
M
---------------
F
G
G
S
Y
S
K
QN
N
RYF
S
S
--------------------
W
A
--
---
-
---
-
--
N
IF-
PD
E
IGSFYNFNG
N
FP
Q
TDWSPQSL
A
QDD
T
T
HMKS
LYA
A
T
RV
T
LADP
L
H
L
I
L
G
A
R
YT
N
W
--
R
V
D
T
L
T
Y
------------
---------
-
-
-----
SMEK
N
HT
T
P
Y
AG
LV
F
D
I
N
DN
W
-
S
T
Y
A
SY
T
S
I
FQ
-----
P
---------
-
Q
NDR
---
D
S
S
G
KY
-
L
AP
I
T
GN
N
YE
L
G
L
K
SDWM
N
S
RL
TT
T
L
A
I
FR
IEQD
N
VAQ
STGTPIPG
S
N
G
E
T
A
Y
KA
V
--
D
GT
V
S
KGVE
F
E
LN
---
GAIT
D
N
WQ
L
T
F
G
A
T
RYI
AE
DNEG
N
AV
N
P
N
--
--
--------
L
P
R
T
TVK
MF
T
S
Y
RLP
V
M
P
--
E
LTVG
G
G
V
NW
Q
N
---
R
VYTDT
V
-
T
P
Y
GT
FR
A
EQ
GSY
A
L
VD
L
FT
RY
Q
V
T
K
----
N
F
S
L
Q
G
NVNNLFD
KT
Y
DTN
VEG
S
I
V
-------
---Y
GAPR
N
F
SI
T
G
T
YQ
F
fig|344601.3.peg.4146
Escherichia coli B171 (21-729/729)
L
AG
CIA
L
ALLP
SA
A
F
AA
P
AT-
--
E
E
T
V
I
VE
G
S
A
---
T
AP
D
D
GE
----
NDYSVTSTSA
GTK
MQM
T
QR
D
I
PQS
V
T
I
VS
Q
Q
R
M
E
DQQ
LQ
T
L
G
E
VM
E
NT
L
G
I
S
---
-
-
-K
S
Q
A
D
S
D
R
A
LY
Y
S
RGF
-
----
Q
ID
N
Y
M
V
DGI
PT
YFESRWN
L
G
D
----
A
LS
D
MALF
ERVEV
V
RG
A
T
G
LM
T
G
T
G
N
P
S
A
A
INMV
R
K
H
A
T
S
REF
K
G
DVSA
EY
GS
WNKE
R
YVA
D
LQSP
L
T
E
DG
KI
R
A
R
I
V
G
GY
Q
N
N
D
S
WL
D
RYNS
E
KT
FF
SG
IVD
A
D
LG
DLTT
L
SAG
----------
-
-
--Y
E
Y
QRI
D
VNS
PT
W
G
--
-
-G
LP
RW
N
T
DG--
--
S
S
NS
Y
D
RARSTAP
D
W
A
YND
KEI
N
KVF
M
T
--------
L
K
Q
R
F
A
DT
W
Q
A
T
L
N
A
T
H
SEV
E
F
D
S
--
KM
MY
V
D
AY
VNKA
D
GMLVG
P
YS
NYGPGFDY
VGGTGWNSGKRKVD
A
LDLFA
D
GSY
E
L
F
GR
Q
-
-
-
-
-
-
-
-
--
-
-
-
H
N
L
M
---------------
F
G
G
S
Y
S
K
QN
N
RYF
S
S
--------------------
W
A
--
---
-
---
-
--
N
IF-
PD
E
IGSFYNFNG
N
FP
Q
TDWSPQSL
A
QDD
T
T
HMKS
LYA
A
T
RV
T
LADP
L
H
L
I
L
G
A
R
YT
N
W
--
R
V
D
T
L
T
Y
------------
---------
-
-
-----
SMEK
N
HT
T
P
Y
AG
LV
F
D
I
N
DN
W
-
S
T
Y
A
SY
T
S
I
FQ
-----
P
---------
-
Q
NDR
---
D
S
S
G
KY
-
L
AP
I
T
GN
N
YE
L
G
L
K
SDWM
N
S
RL
TT
T
L
A
I
FR
IEQD
N
VAQ
STGTPIPG
S
N
G
E
T
A
Y
KA
V
--
D
GT
V
S
KGVE
F
E
LN
---
GAIT
D
N
WQ
L
T
F
G
A
T
RYI
AE
DNEG
N
AV
N
P
N
--
--
--------
L
P
R
T
TVK
MF
T
S
Y
RLP
V
M
P
--
E
LTVG
G
G
V
NW
Q
N
---
R
VYTDT
V
-
T
P
Y
GT
FR
A
EQ
GSY
A
L
VD
L
FT
RY
Q
V
T
K
----
N
F
S
L
Q
G
NVNNLFD
KT
Y
DTN
VEG
S
I
V
-------
---Y
GAPR
N
F
SI
T
G
T
YQ
F
fig|344601.5.peg.4366
Escherichia coli B171 (21-729/729)
L
AG
CIA
L
ALLP
SA
A
F
AA
P
AT-
--
E
E
T
V
I
VE
G
S
A
---
T
AP
D
D
GE
----
NDYSVTSTSA
GTK
MQM
T
QR
D
I
PQS
V
T
I
VS
Q
Q
R
M
E
DQQ
LQ
T
L
G
E
VM
E
NT
L
G
I
S
---
-
-
-K
S
Q
A
D
S
D
R
A
LY
Y
S
RGF
-
----
Q
ID
N
Y
M
V
DGI
PT
YFESRWN
L
G
D
----
A
LS
D
MALF
ERVEV
V
RG
A
T
G
LM
T
G
T
G
N
P
S
A
A
INMV
R
K
H
A
T
S
REF
K
G
DVSA
EY
GS
WNKE
R
YVA
D
LQSP
L
T
E
DG
KI
R
A
R
I
V
G
GY
Q
N
N
D
S
WL
D
RYNS
E
KT
FF
SG
IVD
A
D
LG
DLTT
L
SAG
----------
-
-
--Y
E
Y
QRI
D
VNS
PT
W
G
--
-
-G
LP
RW
N
T
DG--
--
S
S
NS
Y
D
RARSTAP
D
W
A
YND
KEI
N
KVF
M
T
--------
L
K
Q
R
F
A
DT
W
Q
A
T
L
N
A
T
H
SEV
E
F
D
S
--
KM
MY
V
D
AY
VNKA
D
GMLVG
P
YS
NYGPGFDY
VGGTGWNSGKRKVD
A
LDLFA
D
GSY
E
L
F
GR
Q
-
-
-
-
-
-
-
-
--
-
-
-
H
N
L
M
---------------
F
G
G
S
Y
S
K
QN
N
RYF
S
S
--------------------
W
A
--
---
-
---
-
--
N
IF-
PD
E
IGSFYNFNG
N
FP
Q
TDWSPQSL
A
QDD
T
T
HMKS
LYA
A
T
RV
T
LADP
L
H
L
I
L
G
A
R
YT
N
W
--
R
V
D
T
L
T
Y
------------
---------
-
-
-----
SMEK
N
HT
T
P
Y
AG
LV
F
D
I
N
DN
W
-
S
T
Y
A
SY
T
S
I
FQ
-----
P
---------
-
Q
NDR
---
D
S
S
G
KY
-
L
AP
I
T
GN
N
YE
L
G
L
K
SDWM
N
S
RL
TT
T
L
A
I
FR
IEQD
N
VAQ
STGTPIPG
S
N
G
E
T
A
Y
KA
V
--
D
GT
V
S
KGVE
F
E
LN
---
GAIT
D
N
WQ
L
T
F
G
A
T
RYI
AE
DNEG
N
AV
N
P
N
--
--
--------
L
P
R
T
TVK
MF
T
S
Y
RLP
V
M
P
--
E
LTVG
G
G
V
NW
Q
N
---
R
VYTDT
V
-
T
P
Y
GT
FR
A
EQ
GSY
A
L
VD
L
FT
RY
Q
V
T
K
----
N
F
S
L
Q
G
NVNNLFD
KT
Y
DTN
VEG
S
I
V
-------
---Y
GAPR
N
F
SI
T
G
T
YQ
F
fig|550676.3.peg.599
Escherichia coli B185 (21-729/729)
L
AG
CIA
L
ALLP
SA
A
F
AA
P
AT-
--
E
E
T
V
I
VE
G
S
A
---
T
AP
D
D
GE
----
NDYSVTSTSA
GTK
MQM
T
QR
D
I
PQS
V
T
I
VS
Q
Q
R
M
E
DQQ
LQ
T
L
G
E
VM
E
NT
L
G
I
S
---
-
-
-K
S
Q
A
D
S
D
R
A
LY
Y
S
RGF
-
----
Q
ID
N
Y
M
V
DGI
PT
YFESRWN
L
G
D
----
A
LS
D
MALF
ERVEV
V
RG
A
T
G
LM
T
G
T
G
N
P
S
A
A
INMV
R
K
H
A
T
S
REF
K
G
DVSA
EY
GS
WNKE
R
YVA
D
LQSP
L
T
E
DG
KI
R
A
R
I
V
G
GY
Q
N
N
D
S
WL
D
RYNS
E
KT
FF
SG
IVD
A
D
LG
DLTT
L
SAG
----------
-
-
--Y
E
Y
QRI
D
VNS
PT
W
G
--
-
-G
LP
RW
N
T
DG--
--
S
S
NS
Y
D
RARSTAP
D
W
A
YND
KEI
N
KVF
M
T
--------
L
K
Q
R
F
A
DT
W
Q
A
T
L
N
A
T
H
SEV
E
F
D
S
--
KM
MY
V
D
AY
VNKA
D
GMLVG
P
YS
NYGPGFDY
VGGTGWNSGKRKVD
A
LDLFA
D
GSY
E
L
F
GR
Q
-
-
-
-
-
-
-
-
--
-
-
-
H
N
L
M
---------------
F
G
G
S
Y
S
K
QN
N
RYF
S
S
--------------------
W
A
--
---
-
---
-
--
N
IF-
PD
E
IGSFYNFNG
N
FP
Q
TDWSPQSL
A
QDD
T
T
HMKS
LYA
A
T
RV
T
LADP
L
H
L
I
L
G
A
R
YT
N
W
--
R
V
D
T
L
T
Y
------------
---------
-
-
-----
SMEK
N
HT
T
P
Y
AG
LV
F
D
I
N
DN
W
-
S
T
Y
A
SY
T
S
I
FQ
-----
P
---------
-
Q
NDR
---
D
S
S
G
KY
-
L
AP
I
T
GN
N
YE
L
G
L
K
SDWM
N
S
RL
TT
T
L
A
I
FR
IEQD
N
VAQ
STGTPIPG
S
N
G
E
T
A
Y
KA
V
--
D
GT
V
S
KGVE
F
E
LN
---
GAIT
D
N
WQ
L
T
F
G
A
T
RYI
AE
DNEG
N
AV
N
P
N
--
--
--------
L
P
R
T
TVK
MF
T
S
Y
RLP
V
M
P
--
E
LTVG
G
G
V
NW
Q
N
---
R
VYTDT
V
-
T
P
Y
GT
FR
A
EQ
GSY
A
L
VD
L
FT
RY
Q
V
T
K
----
N
F
S
L
Q
G
NVNNLFD
KT
Y
DTN
VEG
S
I
V
-------
---Y
GAPR
N
F
SI
T
G
T
YQ
F
fig|340185.3.peg.4642
Escherichia coli E22 (21-729/729)
L
AG
CIA
L
ALLP
SA
A
F
AA
P
AT-
--
E
E
T
V
I
VE
G
S
A
---
T
AP
D
D
GE
----
NDYSVTSTSA
GTK
MQM
T
QR
D
I
PQS
V
T
I
VS
Q
Q
R
M
E
DQQ
LQ
T
L
G
E
VM
E
NT
L
G
I
S
---
-
-
-K
S
Q
A
D
S
D
R
A
LY
Y
S
RGF
-
----
Q
ID
N
Y
M
V
DGI
PT
YFESRWN
L
G
D
----
A
LS
D
MALF
ERVEV
V
RG
A
T
G
LM
T
G
T
G
N
P
S
A
A
INMV
R
K
H
A
T
S
REF
K
G
DVSA
EY
GS
WNKE
R
YVA
D
LQSP
L
T
E
DG
KI
R
A
R
I
V
G
GY
Q
N
N
D
S
WL
D
RYNS
E
KT
FF
SG
IVD
A
D
LG
DLTT
L
SAG
----------
-
-
--Y
E
Y
QRI
D
VNS
PT
W
G
--
-
-G
LP
RW
N
T
DG--
--
S
S
NS
Y
D
RARSTAP
D
W
A
YND
KEI
N
KVF
M
T
--------
L
K
Q
R
F
A
DT
W
Q
A
T
L
N
A
T
H
SEV
E
F
D
S
--
KM
MY
V
D
AY
VNKA
D
GMLVG
P
YS
NYGPGFDY
VGGTGWNSGKRKVD
A
LDLFA
D
GSY
E
L
F
GR
Q
-
-
-
-
-
-
-
-
--
-
-
-
H
N
L
M
---------------
F
G
G
S
Y
S
K
QN
N
RYF
S
S
--------------------
W
A
--
---
-
---
-
--
N
IF-
PD
E
IGSFYNFNG
N
FP
Q
TDWSPQSL
A
QDD
T
T
HMKS
LYA
A
T
RV
T
LADP
L
H
L
I
L
G
A
R
YT
N
W
--
R
V
D
T
L
T
Y
------------
---------
-
-
-----
SMEK
N
HT
T
P
Y
AG
LV
F
D
I
N
DN
W
-
S
T
Y
A
SY
T
S
I
FQ
-----
P
---------
-
Q
NDR
---
D
S
S
G
KY
-
L
AP
I
T
GN
N
YE
L
G
L
K
SDWM
N
S
RL
TT
T
L
A
I
FR
IEQD
N
VAQ
STGTPIPG
S
N
G
E
T
A
Y
KA
V
--
D
GT
V
S
KGVE
F
E
LN
---
GAIT
D
N
WQ
L
T
F
G
A
T
RYI
AE
DNEG
N
AV
N
P
N
--
--
--------
L
P
R
T
TVK
MF
T
S
Y
RLP
V
M
P
--
E
LTVG
G
G
V
NW
Q
N
---
R
VYTDT
V
-
T
P
Y
GT
FR
A
EQ
GSY
A
L
VD
L
FT
RY
Q
V
T
K
----
N
F
S
L
Q
G
NVNNLFD
KT
Y
DTN
VEG
S
I
V
-------
---Y
GAPR
N
F
SI
T
G
T
YQ
F
fig|340185.4.peg.4902
Escherichia coli E22 (21-729/729)
L
AG
CIA
L
ALLP
SA
A
F
AA
P
AT-
--
E
E
T
V
I
VE
G
S
A
---
T
AP
D
D
GE
----
NDYSVTSTSA
GTK
MQM
T
QR
D
I
PQS
V
T
I
VS
Q
Q
R
M
E
DQQ
LQ
T
L
G
E
VM
E
NT
L
G
I
S
---
-
-
-K
S
Q
A
D
S
D
R
A
LY
Y
S
RGF
-
----
Q
ID
N
Y
M
V
DGI
PT
YFESRWN
L
G
D
----
A
LS
D
MALF
ERVEV
V
RG
A
T
G
LM
T
G
T
G
N
P
S
A
A
INMV
R
K
H
A
T
S
REF
K
G
DVSA
EY
GS
WNKE
R
YVA
D
LQSP
L
T
E
DG
KI
R
A
R
I
V
G
GY
Q
N
N
D
S
WL
D
RYNS
E
KT
FF
SG
IVD
A
D
LG
DLTT
L
SAG
----------
-
-
--Y
E
Y
QRI
D
VNS
PT
W
G
--
-
-G
LP
RW
N
T
DG--
--
S
S
NS
Y
D
RARSTAP
D
W
A
YND
KEI
N
KVF
M
T
--------
L
K
Q
R
F
A
DT
W
Q
A
T
L
N
A
T
H
SEV
E
F
D
S
--
KM
MY
V
D
AY
VNKA
D
GMLVG
P
YS
NYGPGFDY
VGGTGWNSGKRKVD
A
LDLFA
D
GSY
E
L
F
GR
Q
-
-
-
-
-
-
-
-
--
-
-
-
H
N
L
M
---------------
F
G
G
S
Y
S
K
QN
N
RYF
S
S
--------------------
W
A
--
---
-
---
-
--
N
IF-
PD
E
IGSFYNFNG
N
FP
Q
TDWSPQSL
A
QDD
T
T
HMKS
LYA
A
T
RV
T
LADP
L
H
L
I
L
G
A
R
YT
N
W
--
R
V
D
T
L
T
Y
------------
---------
-
-
-----
SMEK
N
HT
T
P
Y
AG
LV
F
D
I
N
DN
W
-
S
T
Y
A
SY
T
S
I
FQ
-----
P
---------
-
Q
NDR
---
D
S
S
G
KY
-
L
AP
I
T
GN
N
YE
L
G
L
K
SDWM
N
S
RL
TT
T
L
A
I
FR
IEQD
N
VAQ
STGTPIPG
S
N
G
E
T
A
Y
KA
V
--
D
GT
V
S
KGVE
F
E
LN
---
GAIT
D
N
WQ
L
T
F
G
A
T
RYI
AE
DNEG
N
AV
N
P
N
--
--
--------
L
P
R
T
TVK
MF
T
S
Y
RLP
V
M
P
--
E
LTVG
G
G
V
NW
Q
N
---
R
VYTDT
V
-
T
P
Y
GT
FR
A
EQ
GSY
A
L
VD
L
FT
RY
Q
V
T
K
----
N
F
S
L
Q
G
NVNNLFD
KT
Y
DTN
VEG
S
I
V
-------
---Y
GAPR
N
F
SI
T
G
T
YQ
F
fig|331111.12.peg.1512
Escherichia coli E24377A (21-729/729)
L
AG
CIA
L
ALLP
SA
A
F
AA
P
AT-
--
E
E
T
V
I
VE
G
S
A
---
T
AP
D
D
GE
----
NDYSVTSTSA
GTK
MQM
T
QR
D
I
PQS
V
T
I
VS
Q
Q
R
M
E
DQQ
LQ
T
L
G
E
VM
E
NT
L
G
I
S
---
-
-
-K
S
Q
A
D
S
D
R
A
LY
Y
S
RGF
-
----
Q
ID
N
Y
M
V
DGI
PT
YFESRWN
L
G
D
----
A
LS
D
MALF
ERVEV
V
RG
A
T
G
LM
T
G
T
G
N
P
S
A
A
INMV
R
K
H
A
T
S
REF
K
G
DVSA
EY
GS
WNKE
R
YVA
D
LQSP
L
T
E
DG
KI
R
A
R
I
V
G
GY
Q
N
N
D
S
WL
D
RYNS
E
KT
FF
SG
IVD
A
D
LG
DLTT
L
SAG
----------
-
-
--Y
E
Y
QRI
D
VNS
PT
W
G
--
-
-G
LP
RW
N
T
DG--
--
S
S
NS
Y
D
RARSTAP
D
W
A
YND
KEI
N
KVF
M
T
--------
L
K
Q
R
F
A
DT
W
Q
A
T
L
N
A
T
H
SEV
E
F
D
S
--
KM
MY
V
D
AY
VNKA
D
GMLVG
P
YS
NYGPGFDY
VGGTGWNSGKRKVD
A
LDLFA
D
GSY
E
L
F
GR
Q
-
-
-
-
-
-
-
-
--
-
-
-
H
N
L
M
---------------
F
G
G
S
Y
S
K
QN
N
RYF
S
S
--------------------
W
A
--
---
-
---
-
--
N
IF-
PD
E
IGSFYNFNG
N
FP
Q
TDWSPQSL
A
QDD
T
T
HMKS
LYA
A
T
RV
T
LADP
L
H
L
I
L
G
A
R
YT
N
W
--
R
V
D
T
L
T
Y
------------
---------
-
-
-----
SMEK
N
HT
T
P
Y
AG
LV
F
D
I
N
DN
W
-
S
T
Y
A
SY
T
S
I
FQ
-----
P
---------
-
Q
NDR
---
D
S
S
G
KY
-
L
AP
I
T
GN
N
YE
L
G
L
K
SDWM
N
S
RL
TT
T
L
A
I
FR
IEQD
N
VAQ
STGTPIPG
S
N
G
E
T
A
Y
KA
V
--
D
GT
V
S
KGVE
F
E
LN
---
GAIT
D
N
WQ
L
T
F
G
A
T
RYI
AE
DNEG
N
AV
N
P
N
--
--
--------
L
P
R
T
TVK
MF
T
S
Y
RLP
V
M
P
--
E
LTVG
G
G
V
NW
Q
N
---
R
VYTDT
V
-
T
P
Y
GT
FR
A
EQ
GSY
A
L
VD
L
FT
RY
Q
V
T
K
----
N
F
S
L
Q
G
NVNNLFD
KT
Y
DTN
VEG
S
I
V
-------
---Y
GAPR
N
F
SI
T
G
T
YQ
F
fig|331111.3.peg.3699
Escherichia coli E24377A (21-729/729)
L
AG
CIA
L
ALLP
SA
A
F
AA
P
AT-
--
E
E
T
V
I
VE
G
S
A
---
T
AP
D
D
GE
----
NDYSVTSTSA
GTK
MQM
T
QR
D
I
PQS
V
T
I
VS
Q
Q
R
M
E
DQQ
LQ
T
L
G
E
VM
E
NT
L
G
I
S
---
-
-
-K
S
Q
A
D
S
D
R
A
LY
Y
S
RGF
-
----
Q
ID
N
Y
M
V
DGI
PT
YFESRWN
L
G
D
----
A
LS
D
MALF
ERVEV
V
RG
A
T
G
LM
T
G
T
G
N
P
S
A
A
INMV
R
K
H
A
T
S
REF
K
G
DVSA
EY
GS
WNKE
R
YVA
D
LQSP
L
T
E
DG
KI
R
A
R
I
V
G
GY
Q
N
N
D
S
WL
D
RYNS
E
KT
FF
SG
IVD
A
D
LG
DLTT
L
SAG
----------
-
-
--Y
E
Y
QRI
D
VNS
PT
W
G
--
-
-G
LP
RW
N
T
DG--
--
S
S
NS
Y
D
RARSTAP
D
W
A
YND
KEI
N
KVF
M
T
--------
L
K
Q
R
F
A
DT
W
Q
A
T
L
N
A
T
H
SEV
E
F
D
S
--
KM
MY
V
D
AY
VNKA
D
GMLVG
P
YS
NYGPGFDY
VGGTGWNSGKRKVD
A
LDLFA
D
GSY
E
L
F
GR
Q
-
-
-
-
-
-
-
-
--
-
-
-
H
N
L
M
---------------
F
G
G
S
Y
S
K
QN
N
RYF
S
S
--------------------
W
A
--
---
-
---
-
--
N
IF-
PD
E
IGSFYNFNG
N
FP
Q
TDWSPQSL
A
QDD
T
T
HMKS
LYA
A
T
RV
T
LADP
L
H
L
I
L
G
A
R
YT
N
W
--
R
V
D
T
L
T
Y
------------
---------
-
-
-----
SMEK
N
HT
T
P
Y
AG
LV
F
D
I
N
DN
W
-
S
T
Y
A
SY
T
S
I
FQ
-----
P
---------
-
Q
NDR
---
D
S
S
G
KY
-
L
AP
I
T
GN
N
YE
L
G
L
K
SDWM
N
S
RL
TT
T
L
A
I
FR
IEQD
N
VAQ
STGTPIPG
S
N
G
E
T
A
Y
KA
V
--
D
GT
V
S
KGVE
F
E
LN
---
GAIT
D
N
WQ
L
T
F
G
A
T
RYI
AE
DNEG
N
AV
N
P
N
--
--
--------
L
P
R
T
TVK
MF
T
S
Y
RLP
V
M
P
--
E
LTVG
G
G
V
NW
Q
N
---
R
VYTDT
V
-
T
P
Y
GT
FR
A
EQ
GSY
A
L
VD
L
FT
RY
Q
V
T
K
----
N
F
S
L
Q
G
NVNNLFD
KT
Y
DTN
VEG
S
I
V
-------
---Y
GAPR
N
F
SI
T
G
T
YQ
F
fig|656419.3.peg.1446
Escherichia coli M718 (21-729/729)
L
AG
CIA
L
ALLP
SA
A
F
AA
P
AT-
--
E
E
T
V
I
VE
G
S
A
---
T
AP
D
D
GE
----
NDYSVTSTSA
GTK
MQM
T
QR
D
I
PQS
V
T
I
VS
Q
Q
R
M
E
DQQ
LQ
T
L
G
E
VM
E
NT
L
G
I
S
---
-
-
-K
S
Q
A
D
S
D
R
A
LY
Y
S
RGF
-
----
Q
ID
N
Y
M
V
DGI
PT
YFESRWN
L
G
D
----
A
LS
D
MALF
ERVEV
V
RG
A
T
G
LM
T
G
T
G
N
P
S
A
A
INMV
R
K
H
A
T
S
REF
K
G
DVSA
EY
GS
WNKE
R
YVA
D
LQSP
L
T
E
DG
KI
R
A
R
I
V
G
GY
Q
N
N
D
S
WL
D
RYNS
E
KT
FF
SG
IVD
A
D
LG
DLTT
L
SAG
----------
-
-
--Y
E
Y
QRI
D
VNS
PT
W
G
--
-
-G
LP
RW
N
T
DG--
--
S
S
NS
Y
D
RARSTAP
D
W
A
YND
KEI
N
KVF
M
T
--------
L
K
Q
R
F
A
DT
W
Q
A
T
L
N
A
T
H
SEV
E
F
D
S
--
KM
MY
V
D
AY
VNKA
D
GMLVG
P
YS
NYGPGFDY
VGGTGWNSGKRKVD
A
LDLFA
D
GSY
E
L
F
GR
Q
-
-
-
-
-
-
-
-
--
-
-
-
H
N
L
M
---------------
F
G
G
S
Y
S
K
QN
N
RYF
S
S
--------------------
W
A
--
---
-
---
-
--
N
IF-
PD
E
IGSFYNFNG
N
FP
Q
TDWSPQSL
A
QDD
T
T
HMKS
LYA
A
T
RV
T
LADP
L
H
L
I
L
G
A
R
YT
N
W
--
R
V
D
T
L
T
Y
------------
---------
-
-
-----
SMEK
N
HT
T
P
Y
AG
LV
F
D
I
N
DN
W
-
S
T
Y
A
SY
T
S
I
FQ
-----
P
---------
-
Q
NDR
---
D
S
S
G
KY
-
L
AP
I
T
GN
N
YE
L
G
L
K
SDWM
N
S
RL
TT
T
L
A
I
FR
IEQD
N
VAQ
STGTPIPG
S
N
G
E
T
A
Y
KA
V
--
D
GT
V
S
KGVE
F
E
LN
---
GAIT
D
N
WQ
L
T
F
G
A
T
RYI
AE
DNEG
N
AV
N
P
N
--
--
--------
L
P
R
T
TVK
MF
T
S
Y
RLP
V
M
P
--
E
LTVG
G
G
V
NW
Q
N
---
R
VYTDT
V
-
T
P
Y
GT
FR
A
EQ
GSY
A
L
VD
L
FT
RY
Q
V
T
K
----
N
F
S
L
Q
G
NVNNLFD
KT
Y
DTN
VEG
S
I
V
-------
---Y
GAPR
N
F
SI
T
G
T
YQ
F
fig|585395.4.peg.1208
Escherichia coli O103:H2 str. 12009 (21-729/729)
L
AG
CIA
L
ALLP
SA
A
F
AA
P
AT-
--
E
E
T
V
I
VE
G
S
A
---
T
AP
D
D
GE
----
NDYSVTSTSA
GTK
MQM
T
QR
D
I
PQS
V
T
I
VS
Q
Q
R
M
E
DQQ
LQ
T
L
G
E
VM
E
NT
L
G
I
S
---
-
-
-K
S
Q
A
D
S
D
R
A
LY
Y
S
RGF
-
----
Q
ID
N
Y
M
V
DGI
PT
YFESRWN
L
G
D
----
A
LS
D
MALF
ERVEV
V
RG
A
T
G
LM
T
G
T
G
N
P
S
A
A
INMV
R
K
H
A
T
S
REF
K
G
DVSA
EY
GS
WNKE
R
YVA
D
LQSP
L
T
E
DG
KI
R
A
R
I
V
G
GY
Q
N
N
D
S
WL
D
RYNS
E
KT
FF
SG
IVD
A
D
LG
DLTT
L
SAG
----------
-
-
--Y
E
Y
QRI
D
VNS
PT
W
G
--
-
-G
LP
RW
N
T
DG--
--
S
S
NS
Y
D
RARSTAP
D
W
A
YND
KEI
N
KVF
M
T
--------
L
K
Q
R
F
A
DT
W
Q
A
T
L
N
A
T
H
SEV
E
F
D
S
--
KM
MY
V
D
AY
VNKA
D
GMLVG
P
YS
NYGPGFDY
VGGTGWNSGKRKVD
A
LDLFA
D
GSY
E
L
F
GR
Q
-
-
-
-
-
-
-
-
--
-
-
-
H
N
L
M
---------------
F
G
G
S
Y
S
K
QN
N
RYF
S
S
--------------------
W
A
--
---
-
---
-
--
N
IF-
PD
E
IGSFYNFNG
N
FP
Q
TDWSPQSL
A
QDD
T
T
HMKS
LYA
A
T
RV
T
LADP
L
H
L
I
L
G
A
R
YT
N
W
--
R
V
D
T
L
T
Y
------------
---------
-
-
-----
SMEK
N
HT
T
P
Y
AG
LV
F
D
I
N
DN
W
-
S
T
Y
A
SY
T
S
I
FQ
-----
P
---------
-
Q
NDR
---
D
S
S
G
KY
-
L
AP
I
T
GN
N
YE
L
G
L
K
SDWM
N
S
RL
TT
T
L
A
I
FR
IEQD
N
VAQ
STGTPIPG
S
N
G
E
T
A
Y
KA
V
--
D
GT
V
S
KGVE
F
E
LN
---
GAIT
D
N
WQ
L
T
F
G
A
T
RYI
AE
DNEG
N
AV
N
P
N
--
--
--------
L
P
R
T
TVK
MF
T
S
Y
RLP
V
M
P
--
E
LTVG
G
G
V
NW
Q
N
---
R
VYTDT
V
-
T
P
Y
GT
FR
A
EQ
GSY
A
L
VD
L
FT
RY
Q
V
T
K
----
N
F
S
L
Q
G
NVNNLFD
KT
Y
DTN
VEG
S
I
V
-------
---Y
GAPR
N
F
SI
T
G
T
YQ
F
fig|83334.1.peg.1528
Escherichia coli O157:H7 (21-729/729)
L
AG
CIA
L
ALLP
SA
A
F
AA
P
AT-
--
E
E
T
V
I
VE
G
S
A
---
T
AP
D
D
GE
----
NDYSVTSTSA
GTK
MQM
T
QR
D
I
PQS
V
T
I
VS
Q
Q
R
M
E
DQQ
LQ
T
L
G
E
VM
E
NT
L
G
I
S
---
-
-
-K
S
Q
A
D
S
D
R
A
LY
Y
S
RGF
-
----
Q
ID
N
Y
M
V
DGI
PT
YFESRWN
L
G
D
----
A
LS
D
MALF
ERVEV
V
RG
A
T
G
LM
T
G
T
G
N
P
S
A
A
INMV
R
K
H
A
T
S
REF
K
G
DVSA
EY
GS
WNKE
R
YVA
D
LQSP
L
T
E
DG
KI
R
A
R
I
V
G
GY
Q
N
N
D
S
WL
D
RYNS
E
KT
FF
SG
IVD
A
D
LG
DLTT
L
SAG
----------
-
-
--Y
E
Y
QRI
D
VNS
PT
W
G
--
-
-G
LP
RW
N
T
DG--
--
S
S
NS
Y
D
RARSTAP
D
W
A
YND
KEI
N
KVF
M
T
--------
L
K
Q
R
F
A
DT
W
Q
A
T
L
N
A
T
H
SEV
E
F
D
S
--
KM
MY
V
D
AY
VNKA
D
GMLVG
P
YS
NYGPGFDY
VGGTGWNSGKRKVD
A
LDLFA
D
GSY
E
L
F
GR
Q
-
-
-
-
-
-
-
-
--
-
-
-
H
N
L
M
---------------
F
G
G
S
Y
S
K
QN
N
RYF
S
S
--------------------
W
A
--
---
-
---
-
--
N
IF-
PD
E
IGSFYNFNG
N
FP
Q
TDWSPQSL
A
QDD
T
T
HMKS
LYA
A
T
RV
T
LADP
L
H
L
I
L
G
A
R
YT
N
W
--
R
V
D
T
L
T
Y
------------
---------
-
-
-----
SMEK
N
HT
T
P
Y
AG
LV
F
D
I
N
DN
W
-
S
T
Y
A
SY
T
S
I
FQ
-----
P
---------
-
Q
NDR
---
D
S
S
G
KY
-
L
AP
I
T
GN
N
YE
L
G
L
K
SDWM
N
S
RL
TT
T
L
A
I
FR
IEQD
N
VAQ
STGTPIPG
S
N
G
E
T
A
Y
KA
V
--
D
GT
V
S
KGVE
F
E
LN
---
GAIT
D
N
WQ
L
T
F
G
A
T
RYI
AE
DNEG
N
AV
N
P
N
--
--
--------
L
P
R
T
TVK
MF
T
S
Y
RLP
V
M
P
--
E
LTVG
G
G
V
NW
Q
N
---
R
VYTDT
V
-
T
P
Y
GT
FR
A
EQ
GSY
A
L
VD
L
FT
RY
Q
V
T
K
----
N
F
S
L
Q
G
NVNNLFD
KT
Y
DTN
VEG
S
I
V
-------
---Y
GAPR
N
F
SI
T
G
T
YQ
F
fig|444454.5.peg.5969
Escherichia coli O157:H7 str. EC4024 (21-729/729)
L
AG
CIA
L
ALLP
SA
A
F
AA
P
AT-
--
E
E
T
V
I
VE
G
S
A
---
T
AP
D
D
GE
----
NDYSVTSTSA
GTK
MQM
T
QR
D
I
PQS
V
T
I
VS
Q
Q
R
M
E
DQQ
LQ
T
L
G
E
VM
E
NT
L
G
I
S
---
-
-
-K
S
Q
A
D
S
D
R
A
LY
Y
S
RGF
-
----
Q
ID
N
Y
M
V
DGI
PT
YFESRWN
L
G
D
----
A
LS
D
MALF
ERVEV
V
RG
A
T
G
LM
T
G
T
G
N
P
S
A
A
INMV
R
K
H
A
T
S
REF
K
G
DVSA
EY
GS
WNKE
R
YVA
D
LQSP
L
T
E
DG
KI
R
A
R
I
V
G
GY
Q
N
N
D
S
WL
D
RYNS
E
KT
FF
SG
IVD
A
D
LG
DLTT
L
SAG
----------
-
-
--Y
E
Y
QRI
D
VNS
PT
W
G
--
-
-G
LP
RW
N
T
DG--
--
S
S
NS
Y
D
RARSTAP
D
W
A
YND
KEI
N
KVF
M
T
--------
L
K
Q
R
F
A
DT
W
Q
A
T
L
N
A
T
H
SEV
E
F
D
S
--
KM
MY
V
D
AY
VNKA
D
GMLVG
P
YS
NYGPGFDY
VGGTGWNSGKRKVD
A
LDLFA
D
GSY
E
L
F
GR
Q
-
-
-
-
-
-
-
-
--
-
-
-
H
N
L
M
---------------
F
G
G
S
Y
S
K
QN
N
RYF
S
S
--------------------
W
A
--
---
-
---
-
--
N
IF-
PD
E
IGSFYNFNG
N
FP
Q
TDWSPQSL
A
QDD
T
T
HMKS
LYA
A
T
RV
T
LADP
L
H
L
I
L
G
A
R
YT
N
W
--
R
V
D
T
L
T
Y
------------
---------
-
-
-----
SMEK
N
HT
T
P
Y
AG
LV
F
D
I
N
DN
W
-
S
T
Y
A
SY
T
S
I
FQ
-----
P
---------
-
Q
NDR
---
D
S
S
G
KY
-
L
AP
I
T
GN
N
YE
L
G
L
K
SDWM
N
S
RL
TT
T
L
A
I
FR
IEQD
N
VAQ
STGTPIPG
S
N
G
E
T
A
Y
KA
V
--
D
GT
V
S
KGVE
F
E
LN
---
GAIT
D
N
WQ
L
T
F
G
A
T
RYI
AE
DNEG
N
AV
N
P
N
--
--
--------
L
P
R
T
TVK
MF
T
S
Y
RLP
V
M
P
--
E
LTVG
G
G
V
NW
Q
N
---
R
VYTDT
V
-
T
P
Y
GT
FR
A
EQ
GSY
A
L
VD
L
FT
RY
Q
V
T
K
----
N
F
S
L
Q
G
NVNNLFD
KT
Y
DTN
VEG
S
I
V
-------
---Y
GAPR
N
F
SI
T
G
T
YQ
F
fig|444449.5.peg.4827
Escherichia coli O157:H7 str. EC4042 (21-729/729)
L
AG
CIA
L
ALLP
SA
A
F
AA
P
AT-
--
E
E
T
V
I
VE
G
S
A
---
T
AP
D
D
GE
----
NDYSVTSTSA
GTK
MQM
T
QR
D
I
PQS
V
T
I
VS
Q
Q
R
M
E
DQQ
LQ
T
L
G
E
VM
E
NT
L
G
I
S
---
-
-
-K
S
Q
A
D
S
D
R
A
LY
Y
S
RGF
-
----
Q
ID
N
Y
M
V
DGI
PT
YFESRWN
L
G
D
----
A
LS
D
MALF
ERVEV
V
RG
A
T
G
LM
T
G
T
G
N
P
S
A
A
INMV
R
K
H
A
T
S
REF
K
G
DVSA
EY
GS
WNKE
R
YVA
D
LQSP
L
T
E
DG
KI
R
A
R
I
V
G
GY
Q
N
N
D
S
WL
D
RYNS
E
KT
FF
SG
IVD
A
D
LG
DLTT
L
SAG
----------
-
-
--Y
E
Y
QRI
D
VNS
PT
W
G
--
-
-G
LP
RW
N
T
DG--
--
S
S
NS
Y
D
RARSTAP
D
W
A
YND
KEI
N
KVF
M
T
--------
L
K
Q
R
F
A
DT
W
Q
A
T
L
N
A
T
H
SEV
E
F
D
S
--
KM
MY
V
D
AY
VNKA
D
GMLVG
P
YS
NYGPGFDY
VGGTGWNSGKRKVD
A
LDLFA
D
GSY
E
L
F
GR
Q
-
-
-
-
-
-
-
-
--
-
-
-
H
N
L
M
---------------
F
G
G
S
Y
S
K
QN
N
RYF
S
S
--------------------
W
A
--
---
-
---
-
--
N
IF-
PD
E
IGSFYNFNG
N
FP
Q
TDWSPQSL
A
QDD
T
T
HMKS
LYA
A
T
RV
T
LADP
L
H
L
I
L
G
A
R
YT
N
W
--
R
V
D
T
L
T
Y
------------
---------
-
-
-----
SMEK
N
HT
T
P
Y
AG
LV
F
D
I
N
DN
W
-
S
T
Y
A
SY
T
S
I
FQ
-----
P
---------
-
Q
NDR
---
D
S
S
G
KY
-
L
AP
I
T
GN
N
YE
L
G
L
K
SDWM
N
S
RL
TT
T
L
A
I
FR
IEQD
N
VAQ
STGTPIPG
S
N
G
E
T
A
Y
KA
V
--
D
GT
V
S
KGVE
F
E
LN
---
GAIT
D
N
WQ
L
T
F
G
A
T
RYI
AE
DNEG
N
AV
N
P
N
--
--
--------
L
P
R
T
TVK
MF
T
S
Y
RLP
V
M
P
--
E
LTVG
G
G
V
NW
Q
N
---
R
VYTDT
V
-
T
P
Y
GT
FR
A
EQ
GSY
A
L
VD
L
FT
RY
Q
V
T
K
----
N
F
S
L
Q
G
NVNNLFD
KT
Y
DTN
VEG
S
I
V
-------
---Y
GAPR
N
F
SI
T
G
T
YQ
F
fig|444448.5.peg.4090
Escherichia coli O157:H7 str. EC4045 (21-729/729)
L
AG
CIA
L
ALLP
SA
A
F
AA
P
AT-
--
E
E
T
V
I
VE
G
S
A
---
T
AP
D
D
GE
----
NDYSVTSTSA
GTK
MQM
T
QR
D
I
PQS
V
T
I
VS
Q
Q
R
M
E
DQQ
LQ
T
L
G
E
VM
E
NT
L
G
I
S
---
-
-
-K
S
Q
A
D
S
D
R
A
LY
Y
S
RGF
-
----
Q
ID
N
Y
M
V
DGI
PT
YFESRWN
L
G
D
----
A
LS
D
MALF
ERVEV
V
RG
A
T
G
LM
T
G
T
G
N
P
S
A
A
INMV
R
K
H
A
T
S
REF
K
G
DVSA
EY
GS
WNKE
R
YVA
D
LQSP
L
T
E
DG
KI
R
A
R
I
V
G
GY
Q
N
N
D
S
WL
D
RYNS
E
KT
FF
SG
IVD
A
D
LG
DLTT
L
SAG
----------
-
-
--Y
E
Y
QRI
D
VNS
PT
W
G
--
-
-G
LP
RW
N
T
DG--
--
S
S
NS
Y
D
RARSTAP
D
W
A
YND
KEI
N
KVF
M
T
--------
L
K
Q
R
F
A
DT
W
Q
A
T
L
N
A
T
H
SEV
E
F
D
S
--
KM
MY
V
D
AY
VNKA
D
GMLVG
P
YS
NYGPGFDY
VGGTGWNSGKRKVD
A
LDLFA
D
GSY
E
L
F
GR
Q
-
-
-
-
-
-
-
-
--
-
-
-
H
N
L
M
---------------
F
G
G
S
Y
S
K
QN
N
RYF
S
S
--------------------
W
A
--
---
-
---
-
--
N
IF-
PD
E
IGSFYNFNG
N
FP
Q
TDWSPQSL
A
QDD
T
T
HMKS
LYA
A
T
RV
T
LADP
L
H
L
I
L
G
A
R
YT
N
W
--
R
V
D
T
L
T
Y
------------
---------
-
-
-----
SMEK
N
HT
T
P
Y
AG
LV
F
D
I
N
DN
W
-
S
T
Y
A
SY
T
S
I
FQ
-----
P
---------
-
Q
NDR
---
D
S
S
G
KY
-
L
AP
I
T
GN
N
YE
L
G
L
K
SDWM
N
S
RL
TT
T
L
A
I
FR
IEQD
N
VAQ
STGTPIPG
S
N
G
E
T
A
Y
KA
V
--
D
GT
V
S
KGVE
F
E
LN
---
GAIT
D
N
WQ
L
T
F
G
A
T
RYI
AE
DNEG
N
AV
N
P
N
--
--
--------
L
P
R
T
TVK
MF
T
S
Y
RLP
V
M
P
--
E
LTVG
G
G
V
NW
Q
N
---
R
VYTDT
V
-
T
P
Y
GT
FR
A
EQ
GSY
A
L
VD
L
FT
RY
Q
V
T
K
----
N
F
S
L
Q
G
NVNNLFD
KT
Y
DTN
VEG
S
I
V
-------
---Y
GAPR
N
F
SI
T
G
T
YQ
F
fig|444453.5.peg.4751
Escherichia coli O157:H7 str. EC4076 (21-729/729)
L
AG
CIA
L
ALLP
SA
A
F
AA
P
AT-
--
E
E
T
V
I
VE
G
S
A
---
T
AP
D
D
GE
----
NDYSVTSTSA
GTK
MQM
T
QR
D
I
PQS
V
T
I
VS
Q
Q
R
M
E
DQQ
LQ
T
L
G
E
VM
E
NT
L
G
I
S
---
-
-
-K
S
Q
A
D
S
D
R
A
LY
Y
S
RGF
-
----
Q
ID
N
Y
M
V
DGI
PT
YFESRWN
L
G
D
----
A
LS
D
MALF
ERVEV
V
RG
A
T
G
LM
T
G
T
G
N
P
S
A
A
INMV
R
K
H
A
T
S
REF
K
G
DVSA
EY
GS
WNKE
R
YVA
D
LQSP
L
T
E
DG
KI
R
A
R
I
V
G
GY
Q
N
N
D
S
WL
D
RYNS
E
KT
FF
SG
IVD
A
D
LG
DLTT
L
SAG
----------
-
-
--Y
E
Y
QRI
D
VNS
PT
W
G
--
-
-G
LP
RW
N
T
DG--
--
S
S
NS
Y
D
RARSTAP
D
W
A
YND
KEI
N
KVF
M
T
--------
L
K
Q
R
F
A
DT
W
Q
A
T
L
N
A
T
H
SEV
E
F
D
S
--
KM
MY
V
D
AY
VNKA
D
GMLVG
P
YS
NYGPGFDY
VGGTGWNSGKRKVD
A
LDLFA
D
GSY
E
L
F
GR
Q
-
-
-
-
-
-
-
-
--
-
-
-
H
N
L
M
---------------
F
G
G
S
Y
S
K
QN
N
RYF
S
S
--------------------
W
A
--
---
-
---
-
--
N
IF-
PD
E
IGSFYNFNG
N
FP
Q
TDWSPQSL
A
QDD
T
T
HMKS
LYA
A
T
RV
T
LADP
L
H
L
I
L
G
A
R
YT
N
W
--
R
V
D
T
L
T
Y
------------
---------
-
-
-----
SMEK
N
HT
T
P
Y
AG
LV
F
D
I
N
DN
W
-
S
T
Y
A
SY
T
S
I
FQ
-----
P
---------
-
Q
NDR
---
D
S
S
G
KY
-
L
AP
I
T
GN
N
YE
L
G
L
K
SDWM
N
S
RL
TT
T
L
A
I
FR
IEQD
N
VAQ
STGTPIPG
S
N
G
E
T
A
Y
KA
V
--
D
GT
V
S
KGVE
F
E
LN
---
GAIT
D
N
WQ
L
T
F
G
A
T
RYI
AE
DNEG
N
AV
N
P
N
--
--
--------
L
P
R
T
TVK
MF
T
S
Y
RLP
V
M
P
--
E
LTVG
G
G
V
NW
Q
N
---
R
VYTDT
V
-
T
P
Y
GT
FR
A
EQ
GSY
A
L
VD
L
FT
RY
Q
V
T
K
----
N
F
S
L
Q
G
NVNNLFD
KT
Y
DTN
VEG
S
I
V
-------
---Y
GAPR
N
F
SI
T
G
T
YQ
F
fig|444452.5.peg.4255
Escherichia coli O157:H7 str. EC4113 (21-729/729)
L
AG
CIA
L
ALLP
SA
A
F
AA
P
AT-
--
E
E
T
V
I
VE
G
S
A
---
T
AP
D
D
GE
----
NDYSVTSTSA
GTK
MQM
T
QR
D
I
PQS
V
T
I
VS
Q
Q
R
M
E
DQQ
LQ
T
L
G
E
VM
E
NT
L
G
I
S
---
-
-
-K
S
Q
A
D
S
D
R
A
LY
Y
S
RGF
-
----
Q
ID
N
Y
M
V
DGI
PT
YFESRWN
L
G
D
----
A
LS
D
MALF
ERVEV
V
RG
A
T
G
LM
T
G
T
G
N
P
S
A
A
INMV
R
K
H
A
T
S
REF
K
G
DVSA
EY
GS
WNKE
R
YVA
D
LQSP
L
T
E
DG
KI
R
A
R
I
V
G
GY
Q
N
N
D
S
WL
D
RYNS
E
KT
FF
SG
IVD
A
D
LG
DLTT
L
SAG
----------
-
-
--Y
E
Y
QRI
D
VNS
PT
W
G
--
-
-G
LP
RW
N
T
DG--
--
S
S
NS
Y
D
RARSTAP
D
W
A
YND
KEI
N
KVF
M
T
--------
L
K
Q
R
F
A
DT
W
Q
A
T
L
N
A
T
H
SEV
E
F
D
S
--
KM
MY
V
D
AY
VNKA
D
GMLVG
P
YS
NYGPGFDY
VGGTGWNSGKRKVD
A
LDLFA
D
GSY
E
L
F
GR
Q
-
-
-
-
-
-
-
-
--
-
-
-
H
N
L
M
---------------
F
G
G
S
Y
S
K
QN
N
RYF
S
S
--------------------
W
A
--
---
-
---
-
--
N
IF-
PD
E
IGSFYNFNG
N
FP
Q
TDWSPQSL
A
QDD
T
T
HMKS
LYA
A
T
RV
T
LADP
L
H
L
I
L
G
A
R
YT
N
W
--
R
V
D
T
L
T
Y
------------
---------
-
-
-----
SMEK
N
HT
T
P
Y
AG
LV
F
D
I
N
DN
W
-
S
T
Y
A
SY
T
S
I
FQ
-----
P
---------
-
Q
NDR
---
D
S
S
G
KY
-
L
AP
I
T
GN
N
YE
L
G
L
K
SDWM
N
S
RL
TT
T
L
A
I
FR
IEQD
N
VAQ
STGTPIPG
S
N
G
E
T
A
Y
KA
V
--
D
GT
V
S
KGVE
F
E
LN
---
GAIT
D
N
WQ
L
T
F
G
A
T
RYI
AE
DNEG
N
AV
N
P
N
--
--
--------
L
P
R
T
TVK
MF
T
S
Y
RLP
V
M
P
--
E
LTVG
G
G
V
NW
Q
N
---
R
VYTDT
V
-
T
P
Y
GT
FR
A
EQ
GSY
A
L
VD
L
FT
RY
Q
V
T
K
----
N
F
S
L
Q
G
NVNNLFD
KT
Y
DTN
VEG
S
I
V
-------
---Y
GAPR
N
F
SI
T
G
T
YQ
F
fig|444450.8.peg.1551
Escherichia coli O157:H7 str. EC4115 (21-729/729)
L
AG
CIA
L
ALLP
SA
A
F
AA
P
AT-
--
E
E
T
V
I
VE
G
S
A
---
T
AP
D
D
GE
----
NDYSVTSTSA
GTK
MQM
T
QR
D
I
PQS
V
T
I
VS
Q
Q
R
M
E
DQQ
LQ
T
L
G
E
VM
E
NT
L
G
I
S
---
-
-
-K
S
Q
A
D
S
D
R
A
LY
Y
S
RGF
-
----
Q
ID
N
Y
M
V
DGI
PT
YFESRWN
L
G
D
----
A
LS
D
MALF
ERVEV
V
RG
A
T
G
LM
T
G
T
G
N
P
S
A
A
INMV
R
K
H
A
T
S
REF
K
G
DVSA
EY
GS
WNKE
R
YVA
D
LQSP
L
T
E
DG
KI
R
A
R
I
V
G
GY
Q
N
N
D
S
WL
D
RYNS
E
KT
FF
SG
IVD
A
D
LG
DLTT
L
SAG
----------
-
-
--Y
E
Y
QRI
D
VNS
PT
W
G
--
-
-G
LP
RW
N
T
DG--
--
S
S
NS
Y
D
RARSTAP
D
W
A
YND
KEI
N
KVF
M
T
--------
L
K
Q
R
F
A
DT
W
Q
A
T
L
N
A
T
H
SEV
E
F
D
S
--
KM
MY
V
D
AY
VNKA
D
GMLVG
P
YS
NYGPGFDY
VGGTGWNSGKRKVD
A
LDLFA
D
GSY
E
L
F
GR
Q
-
-
-
-
-
-
-
-
--
-
-
-
H
N
L
M
---------------
F
G
G
S
Y
S
K
QN
N
RYF
S
S
--------------------
W
A
--
---
-
---
-
--
N
IF-
PD
E
IGSFYNFNG
N
FP
Q
TDWSPQSL
A
QDD
T
T
HMKS
LYA
A
T
RV
T
LADP
L
H
L
I
L
G
A
R
YT
N
W
--
R
V
D
T
L
T
Y
------------
---------
-
-
-----
SMEK
N
HT
T
P
Y
AG
LV
F
D
I
N
DN
W
-
S
T
Y
A
SY
T
S
I
FQ
-----
P
---------
-
Q
NDR
---
D
S
S
G
KY
-
L
AP
I
T
GN
N
YE
L
G
L
K
SDWM
N
S
RL
TT
T
L
A
I
FR
IEQD
N
VAQ
STGTPIPG
S
N
G
E
T
A
Y
KA
V
--
D
GT
V
S
KGVE
F
E
LN
---
GAIT
D
N
WQ
L
T
F
G
A
T
RYI
AE
DNEG
N
AV
N
P
N
--
--
--------
L
P
R
T
TVK
MF
T
S
Y
RLP
V
M
P
--
E
LTVG
G
G
V
NW
Q
N
---
R
VYTDT
V
-
T
P
Y
GT
FR
A
EQ
GSY
A
L
VD
L
FT
RY
Q
V
T
K
----
N
F
S
L
Q
G
NVNNLFD
KT
Y
DTN
VEG
S
I
V
-------
---Y
GAPR
N
F
SI
T
G
T
YQ
F
fig|444451.5.peg.4288
Escherichia coli O157:H7 str. EC4196 (21-729/729)
L
AG
CIA
L
ALLP
SA
A
F
AA
P
AT-
--
E
E
T
V
I
VE
G
S
A
---
T
AP
D
D
GE
----
NDYSVTSTSA
GTK
MQM
T
QR
D
I
PQS
V
T
I
VS
Q
Q
R
M
E
DQQ
LQ
T
L
G
E
VM
E
NT
L
G
I
S
---
-
-
-K
S
Q
A
D
S
D
R
A
LY
Y
S
RGF
-
----
Q
ID
N
Y
M
V
DGI
PT
YFESRWN
L
G
D
----
A
LS
D
MALF
ERVEV
V
RG
A
T
G
LM
T
G
T
G
N
P
S
A
A
INMV
R
K
H
A
T
S
REF
K
G
DVSA
EY
GS
WNKE
R
YVA
D
LQSP
L
T
E
DG
KI
R
A
R
I
V
G
GY
Q
N
N
D
S
WL
D
RYNS
E
KT
FF
SG
IVD
A
D
LG
DLTT
L
SAG
----------
-
-
--Y
E
Y
QRI
D
VNS
PT
W
G
--
-
-G
LP
RW
N
T
DG--
--
S
S
NS
Y
D
RARSTAP
D
W
A
YND
KEI
N
KVF
M
T
--------
L
K
Q
R
F
A
DT
W
Q
A
T
L
N
A
T
H
SEV
E
F
D
S
--
KM
MY
V
D
AY
VNKA
D
GMLVG
P
YS
NYGPGFDY
VGGTGWNSGKRKVD
A
LDLFA
D
GSY
E
L
F
GR
Q
-
-
-
-
-
-
-
-
--
-
-
-
H
N
L
M
---------------
F
G
G
S
Y
S
K
QN
N
RYF
S
S
--------------------
W
A
--
---
-
---
-
--
N
IF-
PD
E
IGSFYNFNG
N
FP
Q
TDWSPQSL
A
QDD
T
T
HMKS
LYA
A
T
RV
T
LADP
L
H
L
I
L
G
A
R
YT
N
W
--
R
V
D
T
L
T
Y
------------
---------
-
-
-----
SMEK
N
HT
T
P
Y
AG
LV
F
D
I
N
DN
W
-
S
T
Y
A
SY
T
S
I
FQ
-----
P
---------
-
Q
NDR
---
D
S
S
G
KY
-
L
AP
I
T
GN
N
YE
L
G
L
K
SDWM
N
S
RL
TT
T
L
A
I
FR
IEQD
N
VAQ
STGTPIPG
S
N
G
E
T
A
Y
KA
V
--
D
GT
V
S
KGVE
F
E
LN
---
GAIT
D
N
WQ
L
T
F
G
A
T
RYI
AE
DNEG
N
AV
N
P
N
--
--
--------
L
P
R
T
TVK
MF
T
S
Y
RLP
V
M
P
--
E
LTVG
G
G
V
NW
Q
N
---
R
VYTDT
V
-
T
P
Y
GT
FR
A
EQ
GSY
A
L
VD
L
FT
RY
Q
V
T
K
----
N
F
S
L
Q
G
NVNNLFD
KT
Y
DTN
VEG
S
I
V
-------
---Y
GAPR
N
F
SI
T
G
T
YQ
F
fig|444447.5.peg.4329
Escherichia coli O157:H7 str. EC4206 (21-729/729)
L
AG
CIA
L
ALLP
SA
A
F
AA
P
AT-
--
E
E
T
V
I
VE
G
S
A
---
T
AP
D
D
GE
----
NDYSVTSTSA
GTK
MQM
T
QR
D
I
PQS
V
T
I
VS
Q
Q
R
M
E
DQQ
LQ
T
L
G
E
VM
E
NT
L
G
I
S
---
-
-
-K
S
Q
A
D
S
D
R
A
LY
Y
S
RGF
-
----
Q
ID
N
Y
M
V
DGI
PT
YFESRWN
L
G
D
----
A
LS
D
MALF
ERVEV
V
RG
A
T
G
LM
T
G
T
G
N
P
S
A
A
INMV
R
K
H
A
T
S
REF
K
G
DVSA
EY
GS
WNKE
R
YVA
D
LQSP
L
T
E
DG
KI
R
A
R
I
V
G
GY
Q
N
N
D
S
WL
D
RYNS
E
KT
FF
SG
IVD
A
D
LG
DLTT
L
SAG
----------
-
-
--Y
E
Y
QRI
D
VNS
PT
W
G
--
-
-G
LP
RW
N
T
DG--
--
S
S
NS
Y
D
RARSTAP
D
W
A
YND
KEI
N
KVF
M
T
--------
L
K
Q
R
F
A
DT
W
Q
A
T
L
N
A
T
H
SEV
E
F
D
S
--
KM
MY
V
D
AY
VNKA
D
GMLVG
P
YS
NYGPGFDY
VGGTGWNSGKRKVD
A
LDLFA
D
GSY
E
L
F
GR
Q
-
-
-
-
-
-
-
-
--
-
-
-
H
N
L
M
---------------
F
G
G
S
Y
S
K
QN
N
RYF
S
S
--------------------
W
A
--
---
-
---
-
--
N
IF-
PD
E
IGSFYNFNG
N
FP
Q
TDWSPQSL
A
QDD
T
T
HMKS
LYA
A
T
RV
T
LADP
L
H
L
I
L
G
A
R
YT
N
W
--
R
V
D
T
L
T
Y
------------
---------
-
-
-----
SMEK
N
HT
T
P
Y
AG
LV
F
D
I
N
DN
W
-
S
T
Y
A
SY
T
S
I
FQ
-----
P
---------
-
Q
NDR
---
D
S
S
G
KY
-
L
AP
I
T
GN
N
YE
L
G
L
K
SDWM
N
S
RL
TT
T
L
A
I
FR
IEQD
N
VAQ
STGTPIPG
S
N
G
E
T
A
Y
KA
V
--
D
GT
V
S
KGVE
F
E
LN
---
GAIT
D
N
WQ
L
T
F
G
A
T
RYI
AE
DNEG
N
AV
N
P
N
--
--
--------
L
P
R
T
TVK
MF
T
S
Y
RLP
V
M
P
--
E
LTVG
G
G
V
NW
Q
N
---
R
VYTDT
V
-
T
P
Y
GT
FR
A
EQ
GSY
A
L
VD
L
FT
RY
Q
V
T
K
----
N
F
S
L
Q
G
NVNNLFD
KT
Y
DTN
VEG
S
I
V
-------
---Y
GAPR
N
F
SI
T
G
T
YQ
F
fig|478004.5.peg.4429
Escherichia coli O157:H7 str. EC4401 (21-729/729)
L
AG
CIA
L
ALLP
SA
A
F
AA
P
AT-
--
E
E
T
V
I
VE
G
S
A
---
T
AP
D
D
GE
----
NDYSVTSTSA
GTK
MQM
T
QR
D
I
PQS
V
T
I
VS
Q
Q
R
M
E
DQQ
LQ
T
L
G
E
VM
E
NT
L
G
I
S
---
-
-
-K
S
Q
A
D
S
D
R
A
LY
Y
S
RGF
-
----
Q
ID
N
Y
M
V
DGI
PT
YFESRWN
L
G
D
----
A
LS
D
MALF
ERVEV
V
RG
A
T
G
LM
T
G
T
G
N
P
S
A
A
INMV
R
K
H
A
T
S
REF
K
G
DVSA
EY
GS
WNKE
R
YVA
D
LQSP
L
T
E
DG
KI
R
A
R
I
V
G
GY
Q
N
N
D
S
WL
D
RYNS
E
KT
FF
SG
IVD
A
D
LG
DLTT
L
SAG
----------
-
-
--Y
E
Y
QRI
D
VNS
PT
W
G
--
-
-G
LP
RW
N
T
DG--
--
S
S
NS
Y
D
RARSTAP
D
W
A
YND
KEI
N
KVF
M
T
--------
L
K
Q
R
F
A
DT
W
Q
A
T
L
N
A
T
H
SEV
E
F
D
S
--
KM
MY
V
D
AY
VNKA
D
GMLVG
P
YS
NYGPGFDY
VGGTGWNSGKRKVD
A
LDLFA
D
GSY
E
L
F
GR
Q
-
-
-
-
-
-
-
-
--
-
-
-
H
N
L
M
---------------
F
G
G
S
Y
S
K
QN
N
RYF
S
S
--------------------
W
A
--
---
-
---
-
--
N
IF-
PD
E
IGSFYNFNG
N
FP
Q
TDWSPQSL
A
QDD
T
T
HMKS
LYA
A
T
RV
T
LADP
L
H
L
I
L
G
A
R
YT
N
W
--
R
V
D
T
L
T
Y
------------
---------
-
-
-----
SMEK
N
HT
T
P
Y
AG
LV
F
D
I
N
DN
W
-
S
T
Y
A
SY
T
S
I
FQ
-----
P
---------
-
Q
NDR
---
D
S
S
G
KY
-
L
AP
I
T
GN
N
YE
L
G
L
K
SDWM
N
S
RL
TT
T
L
A
I
FR
IEQD
N
VAQ
STGTPIPG
S
N
G
E
T
A
Y
KA
V
--
D
GT
V
S
KGVE
F
E
LN
---
GAIT
D
N
WQ
L
T
F
G
A
T
RYI
AE
DNEG
N
AV
N
P
N
--
--
--------
L
P
R
T
TVK
MF
T
S
Y
RLP
V
M
P
--
E
LTVG
G
G
V
NW
Q
N
---
R
VYTDT
V
-
T
P
Y
GT
FR
A
EQ
GSY
A
L
VD
L
FT
RY
Q
V
T
K
----
N
F
S
L
Q
G
NVNNLFD
KT
Y
DTN
VEG
S
I
V
-------
---Y
GAPR
N
F
SI
T
G
T
YQ
F
fig|478006.5.peg.5174
Escherichia coli O157:H7 str. EC4501 (21-729/729)
L
AG
CIA
L
ALLP
SA
A
F
AA
P
AT-
--
E
E
T
V
I
VE
G
S
A
---
T
AP
D
D
GE
----
NDYSVTSTSA
GTK
MQM
T
QR
D
I
PQS
V
T
I
VS
Q
Q
R
M
E
DQQ
LQ
T
L
G
E
VM
E
NT
L
G
I
S
---
-
-
-K
S
Q
A
D
S
D
R
A
LY
Y
S
RGF
-
----
Q
ID
N
Y
M
V
DGI
PT
YFESRWN
L
G
D
----
A
LS
D
MALF
ERVEV
V
RG
A
T
G
LM
T
G
T
G
N
P
S
A
A
INMV
R
K
H
A
T
S
REF
K
G
DVSA
EY
GS
WNKE
R
YVA
D
LQSP
L
T
E
DG
KI
R
A
R
I
V
G
GY
Q
N
N
D
S
WL
D
RYNS
E
KT
FF
SG
IVD
A
D
LG
DLTT
L
SAG
----------
-
-
--Y
E
Y
QRI
D
VNS
PT
W
G
--
-
-G
LP
RW
N
T
DG--
--
S
S
NS
Y
D
RARSTAP
D
W
A
YND
KEI
N
KVF
M
T
--------
L
K
Q
R
F
A
DT
W
Q
A
T
L
N
A
T
H
SEV
E
F
D
S
--
KM
MY
V
D
AY
VNKA
D
GMLVG
P
YS
NYGPGFDY
VGGTGWNSGKRKVD
A
LDLFA
D
GSY
E
L
F
GR
Q
-
-
-
-
-
-
-
-
--
-
-
-
H
N
L
M
---------------
F
G
G
S
Y
S
K
QN
N
RYF
S
S
--------------------
W
A
--
---
-
---
-
--
N
IF-
PD
E
IGSFYNFNG
N
FP
Q
TDWSPQSL
A
QDD
T
T
HMKS
LYA
A
T
RV
T
LADP
L
H
L
I
L
G
A
R
YT
N
W
--
R
V
D
T
L
T
Y
------------
---------
-
-
-----
SMEK
N
HT
T
P
Y
AG
LV
F
D
I
N
DN
W
-
S
T
Y
A
SY
T
S
I
FQ
-----
P
---------
-
Q
NDR
---
D
S
S
G
KY
-
L
AP
I
T
GN
N
YE
L
G
L
K
SDWM
N
S
RL
TT
T
L
A
I
FR
IEQD
N
VAQ
STGTPIPG
S
N
G
E
T
A
Y
KA
V
--
D
GT
V
S
KGVE
F
E
LN
---
GAIT
D
N
WQ
L
T
F
G
A
T
RYI
AE
DNEG
N
AV
N
P
N
--
--
--------
L
P
R
T
TVK
MF
T
S
Y
RLP
V
M
P
--
E
LTVG
G
G
V
NW
Q
N
---
R
VYTDT
V
-
T
P
Y
GT
FR
A
EQ
GSY
A
L
VD
L
FT
RY
Q
V
T
K
----
N
F
S
L
Q
G
NVNNLFD
KT
Y
DTN
VEG
S
I
V
-------
---Y
GAPR
N
F
SI
T
G
T
YQ
F
fig|478007.5.peg.5093
Escherichia coli O157:H7 str. EC508 (21-729/729)
L
AG
CIA
L
ALLP
SA
A
F
AA
P
AT-
--
E
E
T
V
I
VE
G
S
A
---
T
AP
D
D
GE
----
NDYSVTSTSA
GTK
MQM
T
QR
D
I
PQS
V
T
I
VS
Q
Q
R
M
E
DQQ
LQ
T
L
G
E
VM
E
NT
L
G
I
S
---
-
-
-K
S
Q
A
D
S
D
R
A
LY
Y
S
RGF
-
----
Q
ID
N
Y
M
V
DGI
PT
YFESRWN
L
G
D
----
A
LS
D
MALF
ERVEV
V
RG
A
T
G
LM
T
G
T
G
N
P
S
A
A
INMV
R
K
H
A
T
S
REF
K
G
DVSA
EY
GS
WNKE
R
YVA
D
LQSP
L
T
E
DG
KI
R
A
R
I
V
G
GY
Q
N
N
D
S
WL
D
RYNS
E
KT
FF
SG
IVD
A
D
LG
DLTT
L
SAG
----------
-
-
--Y
E
Y
QRI
D
VNS
PT
W
G
--
-
-G
LP
RW
N
T
DG--
--
S
S
NS
Y
D
RARSTAP
D
W
A
YND
KEI
N
KVF
M
T
--------
L
K
Q
R
F
A
DT
W
Q
A
T
L
N
A
T
H
SEV
E
F
D
S
--
KM
MY
V
D
AY
VNKA
D
GMLVG
P
YS
NYGPGFDY
VGGTGWNSGKRKVD
A
LDLFA
D
GSY
E
L
F
GR
Q
-
-
-
-
-
-
-
-
--
-
-
-
H
N
L
M
---------------
F
G
G
S
Y
S
K
QN
N
RYF
S
S
--------------------
W
A
--
---
-
---
-
--
N
IF-
PD
E
IGSFYNFNG
N
FP
Q
TDWSPQSL
A
QDD
T
T
HMKS
LYA
A
T
RV
T
LADP
L
H
L
I
L
G
A
R
YT
N
W
--
R
V
D
T
L
T
Y
------------
---------
-
-
-----
SMEK
N
HT
T
P
Y
AG
LV
F
D
I
N
DN
W
-
S
T
Y
A
SY
T
S
I
FQ
-----
P
---------
-
Q
NDR
---
D
S
S
G
KY
-
L
AP
I
T
GN
N
YE
L
G
L
K
SDWM
N
S
RL
TT
T
L
A
I
FR
IEQD
N
VAQ
STGTPIPG
S
N
G
E
T
A
Y
KA
V
--
D
GT
V
S
KGVE
F
E
LN
---
GAIT
D
N
WQ
L
T
F
G
A
T
RYI
AE
DNEG
N
AV
N
P
N
--
--
--------
L
P
R
T
TVK
MF
T
S
Y
RLP
V
M
P
--
E
LTVG
G
G
V
NW
Q
N
---
R
VYTDT
V
-
T
P
Y
GT
FR
A
EQ
GSY
A
L
VD
L
FT
RY
Q
V
T
K
----
N
F
S
L
Q
G
NVNNLFD
KT
Y
DTN
VEG
S
I
V
-------
---Y
GAPR
N
F
SI
T
G
T
YQ
F
fig|478008.5.peg.5110
Escherichia coli O157:H7 str. EC869 (21-729/729)
L
AG
CIA
L
ALLP
SA
A
F
AA
P
AT-
--
E
E
T
V
I
VE
G
S
A
---
T
AP
D
D
GE
----
NDYSVTSTSA
GTK
MQM
T
QR
D
I
PQS
V
T
I
VS
Q
Q
R
M
E
DQQ
LQ
T
L
G
E
VM
E
NT
L
G
I
S
---
-
-
-K
S
Q
A
D
S
D
R
A
LY
Y
S
RGF
-
----
Q
ID
N
Y
M
V
DGI
PT
YFESRWN
L
G
D
----
A
LS
D
MALF
ERVEV
V
RG
A
T
G
LM
T
G
T
G
N
P
S
A
A
INMV
R
K
H
A
T
S
REF
K
G
DVSA
EY
GS
WNKE
R
YVA
D
LQSP
L
T
E
DG
KI
R
A
R
I
V
G
GY
Q
N
N
D
S
WL
D
RYNS
E
KT
FF
SG
IVD
A
D
LG
DLTT
L
SAG
----------
-
-
--Y
E
Y
QRI
D
VNS
PT
W
G
--
-
-G
LP
RW
N
T
DG--
--
S
S
NS
Y
D
RARSTAP
D
W
A
YND
KEI
N
KVF
M
T
--------
L
K
Q
R
F
A
DT
W
Q
A
T
L
N
A
T
H
SEV
E
F
D
S
--
KM
MY
V
D
AY
VNKA
D
GMLVG
P
YS
NYGPGFDY
VGGTGWNSGKRKVD
A
LDLFA
D
GSY
E
L
F
GR
Q
-
-
-
-
-
-
-
-
--
-
-
-
H
N
L
M
---------------
F
G
G
S
Y
S
K
QN
N
RYF
S
S
--------------------
W
A
--
---
-
---
-
--
N
IF-
PD
E
IGSFYNFNG
N
FP
Q
TDWSPQSL
A
QDD
T
T
HMKS
LYA
A
T
RV
T
LADP
L
H
L
I
L
G
A
R
YT
N
W
--
R
V
D
T
L
T
Y
------------
---------
-
-
-----
SMEK
N
HT
T
P
Y
AG
LV
F
D
I
N
DN
W
-
S
T
Y
A
SY
T
S
I
FQ
-----
P
---------
-
Q
NDR
---
D
S
S
G
KY
-
L
AP
I
T
GN
N
YE
L
G
L
K
SDWM
N
S
RL
TT
T
L
A
I
FR
IEQD
N
VAQ
STGTPIPG
S
N
G
E
T
A
Y
KA
V
--
D
GT
V
S
KGVE
F
E
LN
---
GAIT
D
N
WQ
L
T
F
G
A
T
RYI
AE
DNEG
N
AV
N
P
N
--
--
--------
L
P
R
T
TVK
MF
T
S
Y
RLP
V
M
P
--
E
LTVG
G
G
V
NW
Q
N
---
R
VYTDT
V
-
T
P
Y
GT
FR
A
EQ
GSY
A
L
VD
L
FT
RY
Q
V
T
K
----
N
F
S
L
Q
G
NVNNLFD
KT
Y
DTN
VEG
S
I
V
-------
---Y
GAPR
N
F
SI
T
G
T
YQ
F
fig|637388.3.peg.4079
Escherichia coli O157:H7 str. FRIK2000 (21-729/729)
L
AG
CIA
L
ALLP
SA
A
F
AA
P
AT-
--
E
E
T
V
I
VE
G
S
A
---
T
AP
D
D
GE
----
NDYSVTSTSA
GTK
MQM
T
QR
D
I
PQS
V
T
I
VS
Q
Q
R
M
E
DQQ
LQ
T
L
G
E
VM
E
NT
L
G
I
S
---
-
-
-K
S
Q
A
D
S
D
R
A
LY
Y
S
RGF
-
----
Q
ID
N
Y
M
V
DGI
PT
YFESRWN
L
G
D
----
A
LS
D
MALF
ERVEV
V
RG
A
T
G
LM
T
G
T
G
N
P
S
A
A
INMV
R
K
H
A
T
S
REF
K
G
DVSA
EY
GS
WNKE
R
YVA
D
LQSP
L
T
E
DG
KI
R
A
R
I
V
G
GY
Q
N
N
D
S
WL
D
RYNS
E
KT
FF
SG
IVD
A
D
LG
DLTT
L
SAG
----------
-
-
--Y
E
Y
QRI
D
VNS
PT
W
G
--
-
-G
LP
RW
N
T
DG--
--
S
S
NS
Y
D
RARSTAP
D
W
A
YND
KEI
N
KVF
M
T
--------
L
K
Q
R
F
A
DT
W
Q
A
T
L
N
A
T
H
SEV
E
F
D
S
--
KM
MY
V
D
AY
VNKA
D
GMLVG
P
YS
NYGPGFDY
VGGTGWNSGKRKVD
A
LDLFA
D
GSY
E
L
F
GR
Q
-
-
-
-
-
-
-
-
--
-
-
-
H
N
L
M
---------------
F
G
G
S
Y
S
K
QN
N
RYF
S
S
--------------------
W
A
--
---
-
---
-
--
N
IF-
PD
E
IGSFYNFNG
N
FP
Q
TDWSPQSL
A
QDD
T
T
HMKS
LYA
A
T
RV
T
LADP
L
H
L
I
L
G
A
R
YT
N
W
--
R
V
D
T
L
T
Y
------------
---------
-
-
-----
SMEK
N
HT
T
P
Y
AG
LV
F
D
I
N
DN
W
-
S
T
Y
A
SY
T
S
I
FQ
-----
P
---------
-
Q
NDR
---
D
S
S
G
KY
-
L
AP
I
T
GN
N
YE
L
G
L
K
SDWM
N
S
RL
TT
T
L
A
I
FR
IEQD
N
VAQ
STGTPIPG
S
N
G
E
T
A
Y
KA
V
--
D
GT
V
S
KGVE
F
E
LN
---
GAIT
D
N
WQ
L
T
F
G
A
T
RYI
AE
DNEG
N
AV
N
P
N
--
--
--------
L
P
R
T
TVK
MF
T
S
Y
RLP
V
M
P
--
E
LTVG
G
G
V
NW
Q
N
---
R
VYTDT
V
-
T
P
Y
GT
FR
A
EQ
GSY
A
L
VD
L
FT
RY
Q
V
T
K
----
N
F
S
L
Q
G
NVNNLFD
KT
Y
DTN
VEG
S
I
V
-------
---Y
GAPR
N
F
SI
T
G
T
YQ
F
fig|570506.3.peg.2082
Escherichia coli O157:H7 str. FRIK966 (21-729/729)
L
AG
CIA
L
ALLP
SA
A
F
AA
P
AT-
--
E
E
T
V
I
VE
G
S
A
---
T
AP
D
D
GE
----
NDYSVTSTSA
GTK
MQM
T
QR
D
I
PQS
V
T
I
VS
Q
Q
R
M
E
DQQ
LQ
T
L
G
E
VM
E
NT
L
G
I
S
---
-
-
-K
S
Q
A
D
S
D
R
A
LY
Y
S
RGF
-
----
Q
ID
N
Y
M
V
DGI
PT
YFESRWN
L
G
D
----
A
LS
D
MALF
ERVEV
V
RG
A
T
G
LM
T
G
T
G
N
P
S
A
A
INMV
R
K
H
A
T
S
REF
K
G
DVSA
EY
GS
WNKE
R
YVA
D
LQSP
L
T
E
DG
KI
R
A
R
I
V
G
GY
Q
N
N
D
S
WL
D
RYNS
E
KT
FF
SG
IVD
A
D
LG
DLTT
L
SAG
----------
-
-
--Y
E
Y
QRI
D
VNS
PT
W
G
--
-
-G
LP
RW
N
T
DG--
--
S
S
NS
Y
D
RARSTAP
D
W
A
YND
KEI
N
KVF
M
T
--------
L
K
Q
R
F
A
DT
W
Q
A
T
L
N
A
T
H
SEV
E
F
D
S
--
KM
MY
V
D
AY
VNKA
D
GMLVG
P
YS
NYGPGFDY
VGGTGWNSGKRKVD
A
LDLFA
D
GSY
E
L
F
GR
Q
-
-
-
-
-
-
-
-
--
-
-
-
H
N
L
M
---------------
F
G
G
S
Y
S
K
QN
N
RYF
S
S
--------------------
W
A
--
---
-
---
-
--
N
IF-
PD
E
IGSFYNFNG
N
FP
Q
TDWSPQSL
A
QDD
T
T
HMKS
LYA
A
T
RV
T
LADP
L
H
L
I
L
G
A
R
YT
N
W
--
R
V
D
T
L
T
Y
------------
---------
-
-
-----
SMEK
N
HT
T
P
Y
AG
LV
F
D
I
N
DN
W
-
S
T
Y
A
SY
T
S
I
FQ
-----
P
---------
-
Q
NDR
---
D
S
S
G
KY
-
L
AP
I
T
GN
N
YE
L
G
L
K
SDWM
N
S
RL
TT
T
L
A
I
FR
IEQD
N
VAQ
STGTPIPG
S
N
G
E
T
A
Y
KA
V
--
D
GT
V
S
KGVE
F
E
LN
---
GAIT
D
N
WQ
L
T
F
G
A
T
RYI
AE
DNEG
N
AV
N
P
N
--
--
--------
L
P
R
T
TVK
MF
T
S
Y
RLP
V
M
P
--
E
LTVG
G
G
V
NW
Q
N
---
R
VYTDT
V
-
T
P
Y
GT
FR
A
EQ
GSY
A
L
VD
L
FT
RY
Q
V
T
K
----
N
F
S
L
Q
G
NVNNLFD
KT
Y
DTN
VEG
S
I
V
-------
---Y
GAPR
N
F
SI
T
G
T
YQ
F
fig|386585.9.peg.1580
Escherichia coli O157:H7 str. Sakai (21-729/729)
L
AG
CIA
L
ALLP
SA
A
F
AA
P
AT-
--
E
E
T
V
I
VE
G
S
A
---
T
AP
D
D
GE
----
NDYSVTSTSA
GTK
MQM
T
QR
D
I
PQS
V
T
I
VS
Q
Q
R
M
E
DQQ
LQ
T
L
G
E
VM
E
NT
L
G
I
S
---
-
-
-K
S
Q
A
D
S
D
R
A
LY
Y
S
RGF
-
----
Q
ID
N
Y
M
V
DGI
PT
YFESRWN
L
G
D
----
A
LS
D
MALF
ERVEV
V
RG
A
T
G
LM
T
G
T
G
N
P
S
A
A
INMV
R
K
H
A
T
S
REF
K
G
DVSA
EY
GS
WNKE
R
YVA
D
LQSP
L
T
E
DG
KI
R
A
R
I
V
G
GY
Q
N
N
D
S
WL
D
RYNS
E
KT
FF
SG
IVD
A
D
LG
DLTT
L
SAG
----------
-
-
--Y
E
Y
QRI
D
VNS
PT
W
G
--
-
-G
LP
RW
N
T
DG--
--
S
S
NS
Y
D
RARSTAP
D
W
A
YND
KEI
N
KVF
M
T
--------
L
K
Q
R
F
A
DT
W
Q
A
T
L
N
A
T
H
SEV
E
F
D
S
--
KM
MY
V
D
AY
VNKA
D
GMLVG
P
YS
NYGPGFDY
VGGTGWNSGKRKVD
A
LDLFA
D
GSY
E
L
F
GR
Q
-
-
-
-
-
-
-
-
--
-
-
-
H
N
L
M
---------------
F
G
G
S
Y
S
K
QN
N
RYF
S
S
--------------------
W
A
--
---
-
---
-
--
N
IF-
PD
E
IGSFYNFNG
N
FP
Q
TDWSPQSL
A
QDD
T
T
HMKS
LYA
A
T
RV
T
LADP
L
H
L
I
L
G
A
R
YT
N
W
--
R
V
D
T
L
T
Y
------------
---------
-
-
-----
SMEK
N
HT
T
P
Y
AG
LV
F
D
I
N
DN
W
-
S
T
Y
A
SY
T
S
I
FQ
-----
P
---------
-
Q
NDR
---
D
S
S
G
KY
-
L
AP
I
T
GN
N
YE
L
G
L
K
SDWM
N
S
RL
TT
T
L
A
I
FR
IEQD
N
VAQ
STGTPIPG
S
N
G
E
T
A
Y
KA
V
--
D
GT
V
S
KGVE
F
E
LN
---
GAIT
D
N
WQ
L
T
F
G
A
T
RYI
AE
DNEG
N
AV
N
P
N
--
--
--------
L
P
R
T
TVK
MF
T
S
Y
RLP
V
M
P
--
E
LTVG
G
G
V
NW
Q
N
---
R
VYTDT
V
-
T
P
Y
GT
FR
A
EQ
GSY
A
L
VD
L
FT
RY
Q
V
T
K
----
N
F
S
L
Q
G
NVNNLFD
KT
Y
DTN
VEG
S
I
V
-------
---Y
GAPR
N
F
SI
T
G
T
YQ
F
fig|544404.4.peg.1414
Escherichia coli O157:H7 str. TW14359 (21-729/729)
L
AG
CIA
L
ALLP
SA
A
F
AA
P
AT-
--
E
E
T
V
I
VE
G
S
A
---
T
AP
D
D
GE
----
NDYSVTSTSA
GTK
MQM
T
QR
D
I
PQS
V
T
I
VS
Q
Q
R
M
E
DQQ
LQ
T
L
G
E
VM
E
NT
L
G
I
S
---
-
-
-K
S
Q
A
D
S
D
R
A
LY
Y
S
RGF
-
----
Q
ID
N
Y
M
V
DGI
PT
YFESRWN
L
G
D
----
A
LS
D
MALF
ERVEV
V
RG
A
T
G
LM
T
G
T
G
N
P
S
A
A
INMV
R
K
H
A
T
S
REF
K
G
DVSA
EY
GS
WNKE
R
YVA
D
LQSP
L
T
E
DG
KI
R
A
R
I
V
G
GY
Q
N
N
D
S
WL
D
RYNS
E
KT
FF
SG
IVD
A
D
LG
DLTT
L
SAG
----------
-
-
--Y
E
Y
QRI
D
VNS
PT
W
G
--
-
-G
LP
RW
N
T
DG--
--
S
S
NS
Y
D
RARSTAP
D
W
A
YND
KEI
N
KVF
M
T
--------
L
K
Q
R
F
A
DT
W
Q
A
T
L
N
A
T
H
SEV
E
F
D
S
--
KM
MY
V
D
AY
VNKA
D
GMLVG
P
YS
NYGPGFDY
VGGTGWNSGKRKVD
A
LDLFA
D
GSY
E
L
F
GR
Q
-
-
-
-
-
-
-
-
--
-
-
-
H
N
L
M
---------------
F
G
G
S
Y
S
K
QN
N
RYF
S
S
--------------------
W
A
--
---
-
---
-
--
N
IF-
PD
E
IGSFYNFNG
N
FP
Q
TDWSPQSL
A
QDD
T
T
HMKS
LYA
A
T
RV
T
LADP
L
H
L
I
L
G
A
R
YT
N
W
--
R
V
D
T
L
T
Y
------------
---------
-
-
-----
SMEK
N
HT
T
P
Y
AG
LV
F
D
I
N
DN
W
-
S
T
Y
A
SY
T
S
I
FQ
-----
P
---------
-
Q
NDR
---
D
S
S
G
KY
-
L
AP
I
T
GN
N
YE
L
G
L
K
SDWM
N
S
RL
TT
T
L
A
I
FR
IEQD
N
VAQ
STGTPIPG
S
N
G
E
T
A
Y
KA
V
--
D
GT
V
S
KGVE
F
E
LN
---
GAIT
D
N
WQ
L
T
F
G
A
T
RYI
AE
DNEG
N
AV
N
P
N
--
--
--------
L
P
R
T
TVK
MF
T
S
Y
RLP
V
M
P
--
E
LTVG
G
G
V
NW
Q
N
---
R
VYTDT
V
-
T
P
Y
GT
FR
A
EQ
GSY
A
L
VD
L
FT
RY
Q
V
T
K
----
N
F
S
L
Q
G
NVNNLFD
KT
Y
DTN
VEG
S
I
V
-------
---Y
GAPR
N
F
SI
T
G
T
YQ
F
fig|502346.5.peg.2805
Escherichia coli O157:H7 str. TW14588 (21-729/729)
L
AG
CIA
L
ALLP
SA
A
F
AA
P
AT-
--
E
E
T
V
I
VE
G
S
A
---
T
AP
D
D
GE
----
NDYSVTSTSA
GTK
MQM
T
QR
D
I
PQS
V
T
I
VS
Q
Q
R
M
E
DQQ
LQ
T
L
G
E
VM
E
NT
L
G
I
S
---
-
-
-K
S
Q
A
D
S
D
R
A
LY
Y
S
RGF
-
----
Q
ID
N
Y
M
V
DGI
PT
YFESRWN
L
G
D
----
A
LS
D
MALF
ERVEV
V
RG
A
T
G
LM
T
G
T
G
N
P
S
A
A
INMV
R
K
H
A
T
S
REF
K
G
DVSA
EY
GS
WNKE
R
YVA
D
LQSP
L
T
E
DG
KI
R
A
R
I
V
G
GY
Q
N
N
D
S
WL
D
RYNS
E
KT
FF
SG
IVD
A
D
LG
DLTT
L
SAG
----------
-
-
--Y
E
Y
QRI
D
VNS
PT
W
G
--
-
-G
LP
RW
N
T
DG--
--
S
S
NS
Y
D
RARSTAP
D
W
A
YND
KEI
N
KVF
M
T
--------
L
K
Q
R
F
A
DT
W
Q
A
T
L
N
A
T
H
SEV
E
F
D
S
--
KM
MY
V
D
AY
VNKA
D
GMLVG
P
YS
NYGPGFDY
VGGTGWNSGKRKVD
A
LDLFA
D
GSY
E
L
F
GR
Q
-
-
-
-
-
-
-
-
--
-
-
-
H
N
L
M
---------------
F
G
G
S
Y
S
K
QN
N
RYF
S
S
--------------------
W
A
--
---
-
---
-
--
N
IF-
PD
E
IGSFYNFNG
N
FP
Q
TDWSPQSL
A
QDD
T
T
HMKS
LYA
A
T
RV
T
LADP
L
H
L
I
L
G
A
R
YT
N
W
--
R
V
D
T
L
T
Y
------------
---------
-
-
-----
SMEK
N
HT
T
P
Y
AG
LV
F
D
I
N
DN
W
-
S
T
Y
A
SY
T
S
I
FQ
-----
P
---------
-
Q
NDR
---
D
S
S
G
KY
-
L
AP
I
T
GN
N
YE
L
G
L
K
SDWM
N
S
RL
TT
T
L
A
I
FR
IEQD
N
VAQ
STGTPIPG
S
N
G
E
T
A
Y
KA
V
--
D
GT
V
S
KGVE
F
E
LN
---
GAIT
D
N
WQ
L
T
F
G
A
T
RYI
AE
DNEG
N
AV
N
P
N
--
--
--------
L
P
R
T
TVK
MF
T
S
Y
RLP
V
M
P
--
E
LTVG
G
G
V
NW
Q
N
---
R
VYTDT
V
-
T
P
Y
GT
FR
A
EQ
GSY
A
L
VD
L
FT
RY
Q
V
T
K
----
N
F
S
L
Q
G
NVNNLFD
KT
Y
DTN
VEG
S
I
V
-------
---Y
GAPR
N
F
SI
T
G
T
YQ
F
fig|340184.3.peg.3693
Escherichia coli B7A (21-729/729)
L
AG
CIA
L
ALLP
SA
A
F
AA
P
AT-
--
E
E
T
V
I
VE
G
S
A
---
T
AP
D
D
GE
----
NDYSVTSTSA
GTK
MQM
T
QR
D
I
PQS
V
T
I
VS
Q
Q
R
M
E
DQQ
LQ
T
L
G
E
VM
E
NT
Q
G
I
S
---
-
-
-K
S
Q
A
D
S
D
R
A
LY
Y
S
RGF
-
----
Q
ID
N
Y
M
V
DGI
PT
YFESRWN
L
G
D
----
A
LS
D
MALF
ERVEV
V
RG
A
T
G
LM
T
G
T
G
N
P
S
A
A
INMV
R
K
H
A
T
S
REF
K
G
DVSA
EY
GS
WNKE
R
YVA
D
LQSP
L
T
E
DG
KI
R
A
R
I
V
G
GY
Q
N
N
D
S
WL
D
RYNS
E
KT
FF
SG
IVD
A
D
LG
DLTT
L
SAG
----------
-
-
--Y
E
Y
QRI
D
VNS
PT
W
G
--
-
-G
LP
RW
N
T
DG--
--
S
S
NS
Y
D
RARSTAP
D
W
A
YND
KEI
N
KVF
M
T
--------
L
K
Q
R
F
A
DT
W
Q
A
T
L
N
A
T
H
SEV
E
F
D
S
--
KM
MY
V
D
AY
VNKA
D
GMLVG
P
YS
NYGPGFDY
VGGTGWNSGKRKVD
A
LDLFA
D
GIY
E
L
F
GR
Q
-
-
-
-
-
-
-
-
--
-
-
-
H
N
L
M
---------------
F
G
G
S
Y
S
K
QN
N
RYF
S
S
--------------------
W
A
--
---
-
---
-
--
N
IF-
PD
E
IGSFYNFNG
N
FP
Q
TDWSPQSL
A
QDD
T
T
HMKS
LYA
A
T
RV
T
LADP
L
H
L
I
L
G
A
R
YT
N
W
--
R
V
D
T
L
T
Y
------------
---------
-
-
-----
SMEK
N
HT
T
P
Y
AG
LV
F
D
I
N
DN
W
-
S
T
Y
A
SY
T
S
I
FQ
-----
P
---------
-
Q
NDR
---
D
S
S
G
KY
-
L
AP
I
T
GN
N
YE
L
G
L
K
SDWM
N
S
RL
TT
T
L
A
I
FR
IEQD
N
VAQ
STGTPIPG
S
N
G
E
T
A
Y
KA
V
--
D
GT
V
S
KGVE
F
E
LN
---
GAIT
D
N
WQ
L
T
F
G
A
T
RYI
AE
DNEG
N
AV
N
P
N
--
--
--------
L
P
R
T
TVK
MF
T
S
Y
RLP
V
M
P
--
E
LTVG
G
G
V
NW
Q
N
---
R
VYTDT
V
-
T
P
Y
GT
FR
A
EQ
GSY
A
L
VD
L
FT
RY
Q
V
T
K
----
N
F
S
L
Q
G
NVNNLFD
KT
Y
DTN
VEG
S
I
V
-------
---Y
GAPR
N
F
SI
T
G
T
YQ
F
fig|340184.6.peg.3857
Escherichia coli B7A (21-729/729)
L
AG
CIA
L
ALLP
SA
A
F
AA
P
AT-
--
E
E
T
V
I
VE
G
S
A
---
T
AP
D
D
GE
----
NDYSVTSTSA
GTK
MQM
T
QR
D
I
PQS
V
T
I
VS
Q
Q
R
M
E
DQQ
LQ
T
L
G
E
VM
E
NT
Q
G
I
S
---
-
-
-K
S
Q
A
D
S
D
R
A
LY
Y
S
RGF
-
----
Q
ID
N
Y
M
V
DGI
PT
YFESRWN
L
G
D
----
A
LS
D
MALF
ERVEV
V
RG
A
T
G
LM
T
G
T
G
N
P
S
A
A
INMV
R
K
H
A
T
S
REF
K
G
DVSA
EY
GS
WNKE
R
YVA
D
LQSP
L
T
E
DG
KI
R
A
R
I
V
G
GY
Q
N
N
D
S
WL
D
RYNS
E
KT
FF
SG
IVD
A
D
LG
DLTT
L
SAG
----------
-
-
--Y
E
Y
QRI
D
VNS
PT
W
G
--
-
-G
LP
RW
N
T
DG--
--
S
S
NS
Y
D
RARSTAP
D
W
A
YND
KEI
N
KVF
M
T
--------
L
K
Q
R
F
A
DT
W
Q
A
T
L
N
A
T
H
SEV
E
F
D
S
--
KM
MY
V
D
AY
VNKA
D
GMLVG
P
YS
NYGPGFDY
VGGTGWNSGKRKVD
A
LDLFA
D
GIY
E
L
F
GR
Q
-
-
-
-
-
-
-
-
--
-
-
-
H
N
L
M
---------------
F
G
G
S
Y
S
K
QN
N
RYF
S
S
--------------------
W
A
--
---
-
---
-
--
N
IF-
PD
E
IGSFYNFNG
N
FP
Q
TDWSPQSL
A
QDD
T
T
HMKS
LYA
A
T
RV
T
LADP
L
H
L
I
L
G
A
R
YT
N
W
--
R
V
D
T
L
T
Y
------------
---------
-
-
-----
SMEK
N
HT
T
P
Y
AG
LV
F
D
I
N
DN
W
-
S
T
Y
A
SY
T
S
I
FQ
-----
P
---------
-
Q
NDR
---
D
S
S
G
KY
-
L
AP
I
T
GN
N
YE
L
G
L
K
SDWM
N
S
RL
TT
T
L
A
I
FR
IEQD
N
VAQ
STGTPIPG
S
N
G
E
T
A
Y
KA
V
--
D
GT
V
S
KGVE
F
E
LN
---
GAIT
D
N
WQ
L
T
F
G
A
T
RYI
AE
DNEG
N
AV
N
P
N
--
--
--------
L
P
R
T
TVK
MF
T
S
Y
RLP
V
M
P
--
E
LTVG
G
G
V
NW
Q
N
---
R
VYTDT
V
-
T
P
Y
GT
FR
A
EQ
GSY
A
L
VD
L
FT
RY
Q
V
T
K
----
N
F
S
L
Q
G
NVNNLFD
KT
Y
DTN
VEG
S
I
V
-------
---Y
GAPR
N
F
SI
T
G
T
YQ
F
fig|595496.3.peg.1046
Escherichia coli BW2952 (21-729/729)
L
AG
CIA
L
ALLP
SA
A
F
AA
P
AT-
--
E
E
T
V
I
VE
G
S
A
---
T
AP
D
D
GE
----
NDYSVTSTSA
GTK
MQM
T
QR
D
I
PQS
V
T
I
VS
Q
Q
R
M
E
DQQ
LQ
T
L
G
E
VM
E
NT
L
G
I
S
---
-
-
-K
S
Q
A
D
S
D
R
A
LY
Y
S
RGF
-
----
Q
ID
N
Y
M
V
DGI
PT
YFESRWN
L
G
D
----
A
LS
D
MALF
ERVEV
V
RG
A
T
G
LM
T
G
T
G
N
P
S
A
A
INMV
R
K
H
A
T
S
REF
K
G
DVSA
EY
GS
WNKE
R
YVA
D
LQSP
L
T
E
DG
KI
R
A
R
I
V
G
GY
Q
N
N
D
S
WL
D
RYNS
E
KT
FF
SG
IVD
A
D
LG
DLTT
L
SAG
----------
-
-
--Y
E
Y
QRI
D
VNS
PT
W
G
--
-
-G
LP
RW
N
T
DG--
--
S
S
NS
Y
D
RARSTAP
D
W
A
YND
KEI
N
KVF
M
T
--------
L
K
Q
Q
F
A
DT
W
Q
A
T
L
N
A
T
H
SEV
E
F
D
S
--
KM
MY
V
D
AY
VNKA
D
GMLVG
P
YS
NYGPGFDY
VGGTGWNSGKRKVD
A
LDLFA
D
GSY
E
L
F
GR
Q
-
-
-
-
-
-
-
-
--
-
-
-
H
N
L
M
---------------
F
G
G
S
Y
S
K
QN
N
RYF
S
S
--------------------
W
A
--
---
-
---
-
--
N
IF-
PD
E
IGSFYNFNG
N
FP
Q
TDWSPQSL
A
QDD
T
T
HMKS
LYA
A
T
RV
T
LADP
L
H
L
I
L
G
A
R
YT
N
W
--
R
V
D
T
L
T
Y
------------
---------
-
-
-----
SMEK
N
HT
T
P
Y
AG
LV
F
D
I
N
DN
W
-
S
T
Y
A
SY
T
S
I
FQ
-----
P
---------
-
Q
NDR
---
D
S
S
G
KY
-
L
AP
I
T
GN
N
YE
L
G
L
K
SDWM
N
S
RL
TT
T
L
A
I
FR
IEQD
N
VAQ
STGTPIPG
S
N
G
E
T
A
Y
KA
V
--
D
GT
V
S
KGVE
F
E
LN
---
GAIT
D
N
WQ
L
T
F
G
A
T
RYI
AE
DNEG
N
AV
N
P
N
--
--
--------
L
P
R
T
TVK
MF
T
S
Y
RLP
V
M
P
--
E
LTVG
G
G
V
NW
Q
N
---
R
VYTDT
V
-
T
P
Y
GT
FR
A
EQ
GSY
A
L
VD
L
FT
RY
Q
V
T
K
----
N
F
S
L
Q
G
NVNNLFD
KT
Y
DTN
VEG
S
I
V
-------
---Y
G
T
PR
N
F
SI
T
G
T
YQ
F
fig|536056.3.peg.2680
Escherichia coli DH1 (21-729/729)
L
AG
CIA
L
ALLP
SA
A
F
AA
P
AT-
--
E
E
T
V
I
VE
G
S
A
---
T
AP
D
D
GE
----
NDYSVTSTSA
GTK
MQM
T
QR
D
I
PQS
V
T
I
VS
Q
Q
R
M
E
DQQ
LQ
T
L
G
E
VM
E
NT
L
G
I
S
---
-
-
-K
S
Q
A
D
S
D
R
A
LY
Y
S
RGF
-
----
Q
ID
N
Y
M
V
DGI
PT
YFESRWN
L
G
D
----
A
LS
D
MALF
ERVEV
V
RG
A
T
G
LM
T
G
T
G
N
P
S
A
A
INMV
R
K
H
A
T
S
REF
K
G
DVSA
EY
GS
WNKE
R
YVA
D
LQSP
L
T
E
DG
KI
R
A
R
I
V
G
GY
Q
N
N
D
S
WL
D
RYNS
E
KT
FF
SG
IVD
A
D
LG
DLTT
L
SAG
----------
-
-
--Y
E
Y
QRI
D
VNS
PT
W
G
--
-
-G
LP
RW
N
T
DG--
--
S
S
NS
Y
D
RARSTAP
D
W
A
YND
KEI
N
KVF
M
T
--------
L
K
Q
Q
F
A
DT
W
Q
A
T
L
N
A
T
H
SEV
E
F
D
S
--
KM
MY
V
D
AY
VNKA
D
GMLVG
P
YS
NYGPGFDY
VGGTGWNSGKRKVD
A
LDLFA
D
GSY
E
L
F
GR
Q
-
-
-
-
-
-
-
-
--
-
-
-
H
N
L
M
---------------
F
G
G
S
Y
S
K
QN
N
RYF
S
S
--------------------
W
A
--
---
-
---
-
--
N
IF-
PD
E
IGSFYNFNG
N
FP
Q
TDWSPQSL
A
QDD
T
T
HMKS
LYA
A
T
RV
T
LADP
L
H
L
I
L
G
A
R
YT
N
W
--
R
V
D
T
L
T
Y
------------
---------
-
-
-----
SMEK
N
HT
T
P
Y
AG
LV
F
D
I
N
DN
W
-
S
T
Y
A
SY
T
S
I
FQ
-----
P
---------
-
Q
NDR
---
D
S
S
G
KY
-
L
AP
I
T
GN
N
YE
L
G
L
K
SDWM
N
S
RL
TT
T
L
A
I
FR
IEQD
N
VAQ
STGTPIPG
S
N
G
E
T
A
Y
KA
V
--
D
GT
V
S
KGVE
F
E
LN
---
GAIT
D
N
WQ
L
T
F
G
A
T
RYI
AE
DNEG
N
AV
N
P
N
--
--
--------
L
P
R
T
TVK
MF
T
S
Y
RLP
V
M
P
--
E
LTVG
G
G
V
NW
Q
N
---
R
VYTDT
V
-
T
P
Y
GT
FR
A
EQ
GSY
A
L
VD
L
FT
RY
Q
V
T
K
----
N
F
S
L
Q
G
NVNNLFD
KT
Y
DTN
VEG
S
I
V
-------
---Y
G
T
PR
N
F
SI
T
G
T
YQ
F
fig|316401.4.peg.1346
Escherichia coli ETEC H10407 (21-729/729)
L
AG
CIA
L
ALLP
SA
A
F
AA
P
AT-
--
E
E
T
V
I
VE
G
S
A
---
T
AP
D
D
GE
----
NDYSVTSTSA
GTK
MQM
T
QR
D
I
PQS
V
T
I
VS
Q
Q
R
M
E
DQQ
LQ
T
L
G
E
VM
E
NT
L
G
I
S
---
-
-
-K
S
Q
A
D
S
D
R
A
LY
Y
S
RGF
-
----
Q
ID
N
Y
M
V
DGI
PT
YFESRWN
L
G
D
----
A
LS
D
MALF
ERVEV
V
RG
A
T
G
LM
T
G
T
G
N
P
S
A
A
INMV
R
K
H
A
T
S
REF
K
G
DVSA
EY
GS
WNKE
R
YVA
D
LQSP
L
T
E
DG
KI
R
A
R
I
V
G
GY
Q
N
N
D
S
WL
D
RYNS
E
KT
FF
SG
IVD
A
D
LG
DLTT
L
SAG
----------
-
-
--Y
E
Y
QRI
D
VNS
PT
W
G
--
-
-G
LP
RW
N
T
DG--
--
S
S
NS
Y
D
RARSTAP
D
W
A
YND
KEI
N
KVF
M
T
--------
L
K
Q
Q
F
A
DT
W
Q
A
T
L
N
A
T
H
SEV
E
F
D
S
--
KM
MY
V
D
AY
VNKA
D
GMLVG
P
YS
NYGPGFDY
VGGTGWNSGKRKVD
A
LDLFA
D
GSY
E
L
F
GR
Q
-
-
-
-
-
-
-
-
--
-
-
-
H
N
L
M
---------------
F
G
G
S
Y
S
K
QN
N
RYF
S
S
--------------------
W
A
--
---
-
---
-
--
N
IF-
PD
E
IGSFYNFNG
N
FP
Q
TDWSPQSL
A
QDD
T
T
HMKS
LYA
A
T
RV
T
LADP
L
H
L
I
L
G
A
R
YT
N
W
--
R
V
D
T
L
T
Y
------------
---------
-
-
-----
SMEK
N
HT
T
P
Y
AG
LV
F
D
I
N
DN
W
-
S
T
Y
A
SY
T
S
I
FQ
-----
P
---------
-
Q
NDR
---
D
S
S
G
KY
-
L
AP
I
T
GN
N
YE
L
G
L
K
SDWM
N
S
RL
TT
T
L
A
I
FR
IEQD
N
VAQ
STGTPIPG
S
N
G
E
T
A
Y
KA
V
--
D
GT
V
S
KGVE
F
E
LN
---
GAIT
D
N
WQ
L
T
F
G
A
T
RYI
AE
DNEG
N
AV
N
P
N
--
--
--------
L
P
R
T
TVK
MF
T
S
Y
RLP
V
M
P
--
E
LTVG
G
G
V
NW
Q
N
---
R
VYTDT
V
-
T
P
Y
GT
FR
A
EQ
GSY
A
L
VD
L
FT
RY
Q
V
T
K
----
N
F
S
L
Q
G
NVNNLFD
KT
Y
DTN
VEG
S
I
V
-------
---Y
G
T
PR
N
F
SI
T
G
T
YQ
F
fig|656414.3.peg.1344
Escherichia coli H736 (21-729/729)
L
AG
CIA
L
ALLP
SA
A
F
AA
P
AT-
--
E
E
T
V
I
VE
G
S
A
---
T
AP
D
D
GE
----
NDYSVTSTSA
GTK
MQM
T
QR
D
I
PQS
V
T
I
VS
Q
Q
R
M
E
DQQ
LQ
T
L
G
E
VM
E
NT
L
G
I
S
---
-
-
-K
S
Q
A
D
S
D
R
A
LY
Y
S
RGF
-
----
Q
ID
N
Y
M
V
DGI
PT
YFESRWN
L
G
D
----
A
LS
D
MALF
ERVEV
V
RG
A
T
G
LM
T
G
T
G
N
P
S
A
A
INMV
R
K
H
A
T
S
REF
K
G
DVSA
EY
GS
WNKE
R
YVA
D
LQSP
L
T
E
DG
KI
R
A
R
I
V
G
GY
Q
N
N
D
S
WL
D
RYNS
E
KT
FF
SG
IVD
A
D
LG
DLTT
L
SAG
----------
-
-
--Y
E
Y
QRI
D
VNS
PT
W
G
--
-
-G
LP
RW
N
T
DG--
--
S
S
NS
Y
D
RARSTAP
D
W
A
YND
KEI
N
KVF
M
T
--------
L
K
Q
Q
F
A
DT
W
Q
A
T
L
N
A
T
H
SEV
E
F
D
S
--
KM
MY
V
D
AY
VNKA
D
GMLVG
P
YS
NYGPGFDY
VGGTGWNSGKRKVD
A
LDLFA
D
GSY
E
L
F
GR
Q
-
-
-
-
-
-
-
-
--
-
-
-
H
N
L
M
---------------
F
G
G
S
Y
S
K
QN
N
RYF
S
S
--------------------
W
A
--
---
-
---
-
--
N
IF-
PD
E
IGSFYNFNG
N
FP
Q
TDWSPQSL
A
QDD
T
T
HMKS
LYA
A
T
RV
T
LADP
L
H
L
I
L
G
A
R
YT
N
W
--
R
V
D
T
L
T
Y
------------
---------
-
-
-----
SMEK
N
HT
T
P
Y
AG
LV
F
D
I
N
DN
W
-
S
T
Y
A
SY
T
S
I
FQ
-----
P
---------
-
Q
NDR
---
D
S
S
G
KY
-
L
AP
I
T
GN
N
YE
L
G
L
K
SDWM
N
S
RL
TT
T
L
A
I
FR
IEQD
N
VAQ
STGTPIPG
S
N
G
E
T
A
Y
KA
V
--
D
GT
V
S
KGVE
F
E
LN
---
GAIT
D
N
WQ
L
T
F
G
A
T
RYI
AE
DNEG
N
AV
N
P
N
--
--
--------
L
P
R
T
TVK
MF
T
S
Y
RLP
V
M
P
--
E
LTVG
G
G
V
NW
Q
N
---
R
VYTDT
V
-
T
P
Y
GT
FR
A
EQ
GSY
A
L
VD
L
FT
RY
Q
V
T
K
----
N
F
S
L
Q
G
NVNNLFD
KT
Y
DTN
VEG
S
I
V
-------
---Y
G
T
PR
N
F
SI
T
G
T
YQ
F
fig|83333.1.peg.1087
Escherichia coli K12 (21-729/729)
L
AG
CIA
L
ALLP
SA
A
F
AA
P
AT-
--
E
E
T
V
I
VE
G
S
A
---
T
AP
D
D
GE
----
NDYSVTSTSA
GTK
MQM
T
QR
D
I
PQS
V
T
I
VS
Q
Q
R
M
E
DQQ
LQ
T
L
G
E
VM
E
NT
L
G
I
S
---
-
-
-K
S
Q
A
D
S
D
R
A
LY
Y
S
RGF
-
----
Q
ID
N
Y
M
V
DGI
PT
YFESRWN
L
G
D
----
A
LS
D
MALF
ERVEV
V
RG
A
T
G
LM
T
G
T
G
N
P
S
A
A
INMV
R
K
H
A
T
S
REF
K
G
DVSA
EY
GS
WNKE
R
YVA
D
LQSP
L
T
E
DG
KI
R
A
R
I
V
G
GY
Q
N
N
D
S
WL
D
RYNS
E
KT
FF
SG
IVD
A
D
LG
DLTT
L
SAG
----------
-
-
--Y
E
Y
QRI
D
VNS
PT
W
G
--
-
-G
LP
RW
N
T
DG--
--
S
S
NS
Y
D
RARSTAP
D
W
A
YND
KEI
N
KVF
M
T
--------
L
K
Q
Q
F
A
DT
W
Q
A
T
L
N
A
T
H
SEV
E
F
D
S
--
KM
MY
V
D
AY
VNKA
D
GMLVG
P
YS
NYGPGFDY
VGGTGWNSGKRKVD
A
LDLFA
D
GSY
E
L
F
GR
Q
-
-
-
-
-
-
-
-
--
-
-
-
H
N
L
M
---------------
F
G
G
S
Y
S
K
QN
N
RYF
S
S
--------------------
W
A
--
---
-
---
-
--
N
IF-
PD
E
IGSFYNFNG
N
FP
Q
TDWSPQSL
A
QDD
T
T
HMKS
LYA
A
T
RV
T
LADP
L
H
L
I
L
G
A
R
YT
N
W
--
R
V
D
T
L
T
Y
------------
---------
-
-
-----
SMEK
N
HT
T
P
Y
AG
LV
F
D
I
N
DN
W
-
S
T
Y
A
SY
T
S
I
FQ
-----
P
---------
-
Q
NDR
---
D
S
S
G
KY
-
L
AP
I
T
GN
N
YE
L
G
L
K
SDWM
N
S
RL
TT
T
L
A
I
FR
IEQD
N
VAQ
STGTPIPG
S
N
G
E
T
A
Y
KA
V
--
D
GT
V
S
KGVE
F
E
LN
---
GAIT
D
N
WQ
L
T
F
G
A
T
RYI
AE
DNEG
N
AV
N
P
N
--
--
--------
L
P
R
T
TVK
MF
T
S
Y
RLP
V
M
P
--
E
LTVG
G
G
V
NW
Q
N
---
R
VYTDT
V
-
T
P
Y
GT
FR
A
EQ
GSY
A
L
VD
L
FT
RY
Q
V
T
K
----
N
F
S
L
Q
G
NVNNLFD
KT
Y
DTN
VEG
S
I
V
-------
---Y
G
T
PR
N
F
SI
T
G
T
YQ
F
fig|749538.3.peg.2092
Escherichia coli MS 116-1 (21-729/729)
L
AG
CIA
L
ALLP
SA
A
F
AA
P
AT-
--
E
E
T
V
I
VE
G
S
A
---
T
AP
D
D
GE
----
NDYSVTSTSA
GTK
MQM
T
QR
D
I
PQS
V
T
I
VS
Q
Q
R
M
E
DQQ
LQ
T
L
G
E
VM
E
NT
L
G
I
S
---
-
-
-K
S
Q
A
D
S
D
R
A
LY
Y
S
RGF
-
----
Q
ID
N
Y
M
V
DGI
PT
YFESRWN
L
G
D
----
A
LS
D
MALF
ERVEV
V
RG
A
T
G
LM
T
G
T
G
N
P
S
A
A
INMV
R
K
H
A
T
S
REF
K
G
DVSA
EY
GS
WNKE
R
YVA
D
LQSP
L
T
E
DG
KI
R
A
R
I
V
G
GY
Q
N
N
D
S
WL
D
RYNS
E
KT
FF
SG
IVD
A
D
LG
DLTT
L
SAG
----------
-
-
--Y
E
Y
QRI
D
VNS
PT
W
G
--
-
-G
LP
RW
N
T
DG--
--
S
S
NS
Y
D
RARSTAP
D
W
A
YND
KEI
N
KVF
M
T
--------
L
K
Q
Q
F
A
DT
W
Q
A
T
L
N
A
T
H
SEV
E
F
D
S
--
KM
MY
V
D
AY
VNKA
D
GMLVG
P
YS
NYGPGFDY
VGGTGWNSGKRKVD
A
LDLFA
D
GSY
E
L
F
GR
Q
-
-
-
-
-
-
-
-
--
-
-
-
H
N
L
M
---------------
F
G
G
S
Y
S
K
QN
N
RYF
S
S
--------------------
W
A
--
---
-
---
-
--
N
IF-
PD
E
IGSFYNFNG
N
FP
Q
TDWSPQSL
A
QDD
T
T
HMKS
LYA
A
T
RV
T
LADP
L
H
L
I
L
G
A
R
YT
N
W
--
R
V
D
T
L
T
Y
------------
---------
-
-
-----
SMEK
N
HT
T
P
Y
AG
LV
F
D
I
N
DN
W
-
S
T
Y
A
SY
T
S
I
FQ
-----
P
---------
-
Q
NDR
---
D
S
S
G
KY
-
L
AP
I
T
GN
N
YE
L
G
L
K
SDWM
N
S
RL
TT
T
L
A
I
FR
IEQD
N
VAQ
STGTPIPG
S
N
G
E
T
A
Y
KA
V
--
D
GT
V
S
KGVE
F
E
LN
---
GAIT
D
N
WQ
L
T
F
G
A
T
RYI
AE
DNEG
N
AV
N
P
N
--
--
--------
L
P
R
T
TVK
MF
T
S
Y
RLP
V
M
P
--
E
LTVG
G
G
V
NW
Q
N
---
R
VYTDT
V
-
T
P
Y
GT
FR
A
EQ
GSY
A
L
VD
L
FT
RY
Q
V
T
K
----
N
F
S
L
Q
G
NVNNLFD
KT
Y
DTN
VEG
S
I
V
-------
---Y
G
T
PR
N
F
SI
T
G
T
YQ
F
fig|749540.3.peg.1127
Escherichia coli MS 146-1 (21-729/729)
L
AG
CIA
L
ALLP
SA
A
F
AA
P
AT-
--
E
E
T
V
I
VE
G
S
A
---
T
AP
D
D
GE
----
NDYSVTSTSA
GTK
MQM
T
QR
D
I
PQS
V
T
I
VS
Q
Q
R
M
E
DQQ
LQ
T
L
G
E
VM
E
NT
L
G
I
S
---
-
-
-K
S
Q
A
D
S
D
R
A
LY
Y
S
RGF
-
----
Q
ID
N
Y
M
V
DGI
PT
YFESRWN
L
G
D
----
A
LS
D
MALF
ERVEV
V
RG
A
T
G
LM
T
G
T
G
N
P
S
A
A
INMV
R
K
H
A
T
S
REF
K
G
DVSA
EY
GS
WNKE
R
YVA
D
LQSP
L
T
E
DG
KI
R
A
R
I
V
G
GY
Q
N
N
D
S
WL
D
RYNS
E
KT
FF
SG
IVD
A
D
LG
DLTT
L
SAG
----------
-
-
--Y
E
Y
QRI
D
VNS
PT
W
G
--
-
-G
LP
RW
N
T
DG--
--
S
S
NS
Y
D
RARSTAP
D
W
A
YND
KEI
N
KVF
M
T
--------
L
K
Q
Q
F
A
DT
W
Q
A
T
L
N
A
T
H
SEV
E
F
D
S
--
KM
MY
V
D
AY
VNKA
D
GMLVG
P
YS
NYGPGFDY
VGGTGWNSGKRKVD
A
LDLFA
D
GSY
E
L
F
GR
Q
-
-
-
-
-
-
-
-
--
-
-
-
H
N
L
M
---------------
F
G
G
S
Y
S
K
QN
N
RYF
S
S
--------------------
W
A
--
---
-
---
-
--
N
IF-
PD
E
IGSFYNFNG
N
FP
Q
TDWSPQSL
A
QDD
T
T
HMKS
LYA
A
T
RV
T
LADP
L
H
L
I
L
G
A
R
YT
N
W
--
R
V
D
T
L
T
Y
------------
---------
-
-
-----
SMEK
N
HT
T
P
Y
AG
LV
F
D
I
N
DN
W
-
S
T
Y
A
SY
T
S
I
FQ
-----
P
---------
-
Q
NDR
---
D
S
S
G
KY
-
L
AP
I
T
GN
N
YE
L
G
L
K
SDWM
N
S
RL
TT
T
L
A
I
FR
IEQD
N
VAQ
STGTPIPG
S
N
G
E
T
A
Y
KA
V
--
D
GT
V
S
KGVE
F
E
LN
---
GAIT
D
N
WQ
L
T
F
G
A
T
RYI
AE
DNEG
N
AV
N
P
N
--
--
--------
L
P
R
T
TVK
MF
T
S
Y
RLP
V
M
P
--
E
LTVG
G
G
V
NW
Q
N
---
R
VYTDT
V
-
T
P
Y
GT
FR
A
EQ
GSY
A
L
VD
L
FT
RY
Q
V
T
K
----
N
F
S
L
Q
G
NVNNLFD
KT
Y
DTN
VEG
S
I
V
-------
---Y
G
T
PR
N
F
SI
T
G
T
YQ
F
fig|749548.3.peg.5050
Escherichia coli MS 196-1 (21-729/729)
L
AG
CIA
L
ALLP
SA
A
F
AA
P
AT-
--
E
E
T
V
I
VE
G
S
A
---
T
AP
D
D
GE
----
NDYSVTSTSA
GTK
MQM
T
QR
D
I
PQS
V
T
I
VS
Q
Q
R
M
E
DQQ
LQ
T
L
G
E
VM
E
NT
L
G
I
S
---
-
-
-K
S
Q
A
D
S
D
R
A
LY
Y
S
RGF
-
----
Q
ID
N
Y
M
V
DGI
PT
YFESRWN
L
G
D
----
A
LS
D
MALF
ERVEV
V
RG
A
T
G
LM
T
G
T
G
N
P
S
A
A
INMV
R
K
H
A
T
S
REF
K
G
DVSA
EY
GS
WNKE
R
YVA
D
LQSP
L
T
E
DG
KI
R
A
R
I
V
G
GY
Q
N
N
D
S
WL
D
RYNS
E
KT
FF
SG
IVD
A
D
LG
DLTT
L
SAG
----------
-
-
--Y
E
Y
QRI
D
VNS
PT
W
G
--
-
-G
LP
RW
N
T
DG--
--
S
S
NS
Y
D
RARSTAP
D
W
A
YND
KEI
N
KVF
M
T
--------
L
K
Q
Q
F
A
DT
W
Q
A
T
L
N
A
T
H
SEV
E
F
D
S
--
KM
MY
V
D
AY
VNKA
D
GMLVG
P
YS
NYGPGFDY
VGGTGWNSGKRKVD
A
LDLFA
D
GSY
E
L
F
GR
Q
-
-
-
-
-
-
-
-
--
-
-
-
H
N
L
M
---------------
F
G
G
S
Y
S
K
QN
N
RYF
S
S
--------------------
W
A
--
---
-
---
-
--
N
IF-
PD
E
IGSFYNFNG
N
FP
Q
TDWSPQSL
A
QDD
T
T
HMKS
LYA
A
T
RV
T
LADP
L
H
L
I
L
G
A
R
YT
N
W
--
R
V
D
T
L
T
Y
------------
---------
-
-
-----
SMEK
N
HT
T
P
Y
AG
LV
F
D
I
N
DN
W
-
S
T
Y
A
SY
T
S
I
FQ
-----
P
---------
-
Q
NDR
---
D
S
S
G
KY
-
L
AP
I
T
GN
N
YE
L
G
L
K
SDWM
N
S
RL
TT
T
L
A
I
FR
IEQD
N
VAQ
STGTPIPG
S
N
G
E
T
A
Y
KA
V
--
D
GT
V
S
KGVE
F
E
LN
---
GAIT
D
N
WQ
L
T
F
G
A
T
RYI
AE
DNEG
N
AV
N
P
N
--
--
--------
L
P
R
T
TVK
MF
T
S
Y
RLP
V
M
P
--
E
LTVG
G
G
V
NW
Q
N
---
R
VYTDT
V
-
T
P
Y
GT
FR
A
EQ
GSY
A
L
VD
L
FT
RY
Q
V
T
K
----
N
F
S
L
Q
G
NVNNLFD
KT
Y
DTN
VEG
S
I
V
-------
---Y
G
T
PR
N
F
SI
T
G
T
YQ
F
fig|316407.3.peg.1064
Escherichia coli W3110 (21-729/729)
L
AG
CIA
L
ALLP
SA
A
F
AA
P
AT-
--
E
E
T
V
I
VE
G
S
A
---
T
AP
D
D
GE
----
NDYSVTSTSA
GTK
MQM
T
QR
D
I
PQS
V
T
I
VS
Q
Q
R
M
E
DQQ
LQ
T
L
G
E
VM
E
NT
L
G
I
S
---
-
-
-K
S
Q
A
D
S
D
R
A
LY
Y
S
RGF
-
----
Q
ID
N
Y
M
V
DGI
PT
YFESRWN
L
G
D
----
A
LS
D
MALF
ERVEV
V
RG
A
T
G
LM
T
G
T
G
N
P
S
A
A
INMV
R
K
H
A
T
S
REF
K
G
DVSA
EY
GS
WNKE
R
YVA
D
LQSP
L
T
E
DG
KI
R
A
R
I
V
G
GY
Q
N
N
D
S
WL
D
RYNS
E
KT
FF
SG
IVD
A
D
LG
DLTT
L
SAG
----------
-
-
--Y
E
Y
QRI
D
VNS
PT
W
G
--
-
-G
LP
RW
N
T
DG--
--
S
S
NS
Y
D
RARSTAP
D
W
A
YND
KEI
N
KVF
M
T
--------
L
K
Q
Q
F
A
DT
W
Q
A
T
L
N
A
T
H
SEV
E
F
D
S
--
KM
MY
V
D
AY
VNKA
D
GMLVG
P
YS
NYGPGFDY
VGGTGWNSGKRKVD
A
LDLFA
D
GSY
E
L
F
GR
Q
-
-
-
-
-
-
-
-
--
-
-
-
H
N
L
M
---------------
F
G
G
S
Y
S
K
QN
N
RYF
S
S
--------------------
W
A
--
---
-
---
-
--
N
IF-
PD
E
IGSFYNFNG
N
FP
Q
TDWSPQSL
A
QDD
T
T
HMKS
LYA
A
T
RV
T
LADP
L
H
L
I
L
G
A
R
YT
N
W
--
R
V
D
T
L
T
Y
------------
---------
-
-
-----
SMEK
N
HT
T
P
Y
AG
LV
F
D
I
N
DN
W
-
S
T
Y
A
SY
T
S
I
FQ
-----
P
---------
-
Q
NDR
---
D
S
S
G
KY
-
L
AP
I
T
GN
N
YE
L
G
L
K
SDWM
N
S
RL
TT
T
L
A
I
FR
IEQD
N
VAQ
STGTPIPG
S
N
G
E
T
A
Y
KA
V
--
D
GT
V
S
KGVE
F
E
LN
---
GAIT
D
N
WQ
L
T
F
G
A
T
RYI
AE
DNEG
N
AV
N
P
N
--
--
--------
L
P
R
T
TVK
MF
T
S
Y
RLP
V
M
P
--
E
LTVG
G
G
V
NW
Q
N
---
R
VYTDT
V
-
T
P
Y
GT
FR
A
EQ
GSY
A
L
VD
L
FT
RY
Q
V
T
K
----
N
F
S
L
Q
G
NVNNLFD
KT
Y
DTN
VEG
S
I
V
-------
---Y
G
T
PR
N
F
SI
T
G
T
YQ
F
fig|316385.5.peg.1178
Escherichia coli str. K-12 substr. DH10B (21-729/729)
L
AG
CIA
L
ALLP
SA
A
F
AA
P
AT-
--
E
E
T
V
I
VE
G
S
A
---
T
AP
D
D
GE
----
NDYSVTSTSA
GTK
MQM
T
QR
D
I
PQS
V
T
I
VS
Q
Q
R
M
E
DQQ
LQ
T
L
G
E
VM
E
NT
L
G
I
S
---
-
-
-K
S
Q
A
D
S
D
R
A
LY
Y
S
RGF
-
----
Q
ID
N
Y
M
V
DGI
PT
YFESRWN
L
G
D
----
A
LS
D
MALF
ERVEV
V
RG
A
T
G
LM
T
G
T
G
N
P
S
A
A
INMV
R
K
H
A
T
S
REF
K
G
DVSA
EY
GS
WNKE
R
YVA
D
LQSP
L
T
E
DG
KI
R
A
R
I
V
G
GY
Q
N
N
D
S
WL
D
RYNS
E
KT
FF
SG
IVD
A
D
LG
DLTT
L
SAG
----------
-
-
--Y
E
Y
QRI
D
VNS
PT
W
G
--
-
-G
LP
RW
N
T
DG--
--
S
S
NS
Y
D
RARSTAP
D
W
A
YND
KEI
N
KVF
M
T
--------
L
K
Q
Q
F
A
DT
W
Q
A
T
L
N
A
T
H
SEV
E
F
D
S
--
KM
MY
V
D
AY
VNKA
D
GMLVG
P
YS
NYGPGFDY
VGGTGWNSGKRKVD
A
LDLFA
D
GSY
E
L
F
GR
Q
-
-
-
-
-
-
-
-
--
-
-
-
H
N
L
M
---------------
F
G
G
S
Y
S
K
QN
N
RYF
S
S
--------------------
W
A
--
---
-
---
-
--
N
IF-
PD
E
IGSFYNFNG
N
FP
Q
TDWSPQSL
A
QDD
T
T
HMKS
LYA
A
T
RV
T
LADP
L
H
L
I
L
G
A
R
YT
N
W
--
R
V
D
T
L
T
Y
------------
---------
-
-
-----
SMEK
N
HT
T
P
Y
AG
LV
F
D
I
N
DN
W
-
S
T
Y
A
SY
T
S
I
FQ
-----
P
---------
-
Q
NDR
---
D
S
S
G
KY
-
L
AP
I
T
GN
N
YE
L
G
L
K
SDWM
N
S
RL
TT
T
L
A
I
FR
IEQD
N
VAQ
STGTPIPG
S
N
G
E
T
A
Y
KA
V
--
D
GT
V
S
KGVE
F
E
LN
---
GAIT
D
N
WQ
L
T
F
G
A
T
RYI
AE
DNEG
N
AV
N
P
N
--
--
--------
L
P
R
T
TVK
MF
T
S
Y
RLP
V
M
P
--
E
LTVG
G
G
V
NW
Q
N
---
R
VYTDT
V
-
T
P
Y
GT
FR
A
EQ
GSY
A
L
VD
L
FT
RY
Q
V
T
K
----
N
F
S
L
Q
G
NVNNLFD
KT
Y
DTN
VEG
S
I
V
-------
---Y
G
T
PR
N
F
SI
T
G
T
YQ
F
fig|316385.7.peg.1198
Escherichia coli str. K-12 substr. DH10B (21-729/729)
L
AG
CIA
L
ALLP
SA
A
F
AA
P
AT-
--
E
E
T
V
I
VE
G
S
A
---
T
AP
D
D
GE
----
NDYSVTSTSA
GTK
MQM
T
QR
D
I
PQS
V
T
I
VS
Q
Q
R
M
E
DQQ
LQ
T
L
G
E
VM
E
NT
L
G
I
S
---
-
-
-K
S
Q
A
D
S
D
R
A
LY
Y
S
RGF
-
----
Q
ID
N
Y
M
V
DGI
PT
YFESRWN
L
G
D
----
A
LS
D
MALF
ERVEV
V
RG
A
T
G
LM
T
G
T
G
N
P
S
A
A
INMV
R
K
H
A
T
S
REF
K
G
DVSA
EY
GS
WNKE
R
YVA
D
LQSP
L
T
E
DG
KI
R
A
R
I
V
G
GY
Q
N
N
D
S
WL
D
RYNS
E
KT
FF
SG
IVD
A
D
LG
DLTT
L
SAG
----------
-
-
--Y
E
Y
QRI
D
VNS
PT
W
G
--
-
-G
LP
RW
N
T
DG--
--
S
S
NS
Y
D
RARSTAP
D
W
A
YND
KEI
N
KVF
M
T
--------
L
K
Q
Q
F
A
DT
W
Q
A
T
L
N
A
T
H
SEV
E
F
D
S
--
KM
MY
V
D
AY
VNKA
D
GMLVG
P
YS
NYGPGFDY
VGGTGWNSGKRKVD
A
LDLFA
D
GSY
E
L
F
GR
Q
-
-
-
-
-
-
-
-
--
-
-
-
H
N
L
M
---------------
F
G
G
S
Y
S
K
QN
N
RYF
S
S
--------------------
W
A
--
---
-
---
-
--
N
IF-
PD
E
IGSFYNFNG
N
FP
Q
TDWSPQSL
A
QDD
T
T
HMKS
LYA
A
T
RV
T
LADP
L
H
L
I
L
G
A
R
YT
N
W
--
R
V
D
T
L
T
Y
------------
---------
-
-
-----
SMEK
N
HT
T
P
Y
AG
LV
F
D
I
N
DN
W
-
S
T
Y
A
SY
T
S
I
FQ
-----
P
---------
-
Q
NDR
---
D
S
S
G
KY
-
L
AP
I
T
GN
N
YE
L
G
L
K
SDWM
N
S
RL
TT
T
L
A
I
FR
IEQD
N
VAQ
STGTPIPG
S
N
G
E
T
A
Y
KA
V
--
D
GT
V
S
KGVE
F
E
LN
---
GAIT
D
N
WQ
L
T
F
G
A
T
RYI
AE
DNEG
N
AV
N
P
N
--
--
--------
L
P
R
T
TVK
MF
T
S
Y
RLP
V
M
P
--
E
LTVG
G
G
V
NW
Q
N
---
R
VYTDT
V
-
T
P
Y
GT
FR
A
EQ
GSY
A
L
VD
L
FT
RY
Q
V
T
K
----
N
F
S
L
Q
G
NVNNLFD
KT
Y
DTN
VEG
S
I
V
-------
---Y
G
T
PR
N
F
SI
T
G
T
YQ
F
fig|511145.12.peg.1145
Escherichia coli str. K-12 substr. MG1655 (21-729/729)
L
AG
CIA
L
ALLP
SA
A
F
AA
P
AT-
--
E
E
T
V
I
VE
G
S
A
---
T
AP
D
D
GE
----
NDYSVTSTSA
GTK
MQM
T
QR
D
I
PQS
V
T
I
VS
Q
Q
R
M
E
DQQ
LQ
T
L
G
E
VM
E
NT
L
G
I
S
---
-
-
-K
S
Q
A
D
S
D
R
A
LY
Y
S
RGF
-
----
Q
ID
N
Y
M
V
DGI
PT
YFESRWN
L
G
D
----
A
LS
D
MALF
ERVEV
V
RG
A
T
G
LM
T
G
T
G
N
P
S
A
A
INMV
R
K
H
A
T
S
REF
K
G
DVSA
EY
GS
WNKE
R
YVA
D
LQSP
L
T
E
DG
KI
R
A
R
I
V
G
GY
Q
N
N
D
S
WL
D
RYNS
E
KT
FF
SG
IVD
A
D
LG
DLTT
L
SAG
----------
-
-
--Y
E
Y
QRI
D
VNS
PT
W
G
--
-
-G
LP
RW
N
T
DG--
--
S
S
NS
Y
D
RARSTAP
D
W
A
YND
KEI
N
KVF
M
T
--------
L
K
Q
Q
F
A
DT
W
Q
A
T
L
N
A
T
H
SEV
E
F
D
S
--
KM
MY
V
D
AY
VNKA
D
GMLVG
P
YS
NYGPGFDY
VGGTGWNSGKRKVD
A
LDLFA
D
GSY
E
L
F
GR
Q
-
-
-
-
-
-
-
-
--
-
-
-
H
N
L
M
---------------
F
G
G
S
Y
S
K
QN
N
RYF
S
S
--------------------
W
A
--
---
-
---
-
--
N
IF-
PD
E
IGSFYNFNG
N
FP
Q
TDWSPQSL
A
QDD
T
T
HMKS
LYA
A
T
RV
T
LADP
L
H
L
I
L
G
A
R
YT
N
W
--
R
V
D
T
L
T
Y
------------
---------
-
-
-----
SMEK
N
HT
T
P
Y
AG
LV
F
D
I
N
DN
W
-
S
T
Y
A
SY
T
S
I
FQ
-----
P
---------
-
Q
NDR
---
D
S
S
G
KY
-
L
AP
I
T
GN
N
YE
L
G
L
K
SDWM
N
S
RL
TT
T
L
A
I
FR
IEQD
N
VAQ
STGTPIPG
S
N
G
E
T
A
Y
KA
V
--
D
GT
V
S
KGVE
F
E
LN
---
GAIT
D
N
WQ
L
T
F
G
A
T
RYI
AE
DNEG
N
AV
N
P
N
--
--
--------
L
P
R
T
TVK
MF
T
S
Y
RLP
V
M
P
--
E
LTVG
G
G
V
NW
Q
N
---
R
VYTDT
V
-
T
P
Y
GT
FR
A
EQ
GSY
A
L
VD
L
FT
RY
Q
V
T
K
----
N
F
S
L
Q
G
NVNNLFD
KT
Y
DTN
VEG
S
I
V
-------
---Y
G
T
PR
N
F
SI
T
G
T
YQ
F
fig|511145.6.peg.1137
Escherichia coli str. K-12 substr. MG1655 (21-729/729)
L
AG
CIA
L
ALLP
SA
A
F
AA
P
AT-
--
E
E
T
V
I
VE
G
S
A
---
T
AP
D
D
GE
----
NDYSVTSTSA
GTK
MQM
T
QR
D
I
PQS
V
T
I
VS
Q
Q
R
M
E
DQQ
LQ
T
L
G
E
VM
E
NT
L
G
I
S
---
-
-
-K
S
Q
A
D
S
D
R
A
LY
Y
S
RGF
-
----
Q
ID
N
Y
M
V
DGI
PT
YFESRWN
L
G
D
----
A
LS
D
MALF
ERVEV
V
RG
A
T
G
LM
T
G
T
G
N
P
S
A
A
INMV
R
K
H
A
T
S
REF
K
G
DVSA
EY
GS
WNKE
R
YVA
D
LQSP
L
T
E
DG
KI
R
A
R
I
V
G
GY
Q
N
N
D
S
WL
D
RYNS
E
KT
FF
SG
IVD
A
D
LG
DLTT
L
SAG
----------
-
-
--Y
E
Y
QRI
D
VNS
PT
W
G
--
-
-G
LP
RW
N
T
DG--
--
S
S
NS
Y
D
RARSTAP
D
W
A
YND
KEI
N
KVF
M
T
--------
L
K
Q
Q
F
A
DT
W
Q
A
T
L
N
A
T
H
SEV
E
F
D
S
--
KM
MY
V
D
AY
VNKA
D
GMLVG
P
YS
NYGPGFDY
VGGTGWNSGKRKVD
A
LDLFA
D
GSY
E
L
F
GR
Q
-
-
-
-
-
-
-
-
--
-
-
-
H
N
L
M
---------------
F
G
G
S
Y
S
K
QN
N
RYF
S
S
--------------------
W
A
--
---
-
---
-
--
N
IF-
PD
E
IGSFYNFNG
N
FP
Q
TDWSPQSL
A
QDD
T
T
HMKS
LYA
A
T
RV
T
LADP
L
H
L
I
L
G
A
R
YT
N
W
--
R
V
D
T
L
T
Y
------------
---------
-
-
-----
SMEK
N
HT
T
P
Y
AG
LV
F
D
I
N
DN
W
-
S
T
Y
A
SY
T
S
I
FQ
-----
P
---------
-
Q
NDR
---
D
S
S
G
KY
-
L
AP
I
T
GN
N
YE
L
G
L
K
SDWM
N
S
RL
TT
T
L
A
I
FR
IEQD
N
VAQ
STGTPIPG
S
N
G
E
T
A
Y
KA
V
--
D
GT
V
S
KGVE
F
E
LN
---
GAIT
D
N
WQ
L
T
F
G
A
T
RYI
AE
DNEG
N
AV
N
P
N
--
--
--------
L
P
R
T
TVK
MF
T
S
Y
RLP
V
M
P
--
E
LTVG
G
G
V
NW
Q
N
---
R
VYTDT
V
-
T
P
Y
GT
FR
A
EQ
GSY
A
L
VD
L
FT
RY
Q
V
T
K
----
N
F
S
L
Q
G
NVNNLFD
KT
Y
DTN
VEG
S
I
V
-------
---Y
G
T
PR
N
F
SI
T
G
T
YQ
F
fig|358709.5.peg.4466
Escherichia coli 101-1 (21-729/729)
L
AG
CIA
L
ALLP
SA
A
F
AA
P
AT-
--
E
E
T
V
I
VE
G
S
A
---
T
AP
D
D
GE
----
NDYSVTSTSA
GTK
MQM
T
QR
D
I
PQS
V
T
I
VS
Q
Q
R
M
E
DQQ
LQ
T
L
G
E
VM
E
NT
L
G
I
S
---
-
-
-K
S
Q
A
D
S
D
R
A
LY
Y
S
RGF
-
----
Q
ID
N
Y
M
V
DGI
PT
YFESRWN
L
G
D
----
A
LS
D
MALF
ERVEV
V
RG
A
T
G
LM
T
G
T
G
N
P
S
A
A
INMV
R
K
H
A
T
S
REF
K
G
DVSA
EY
GS
WNKE
R
YVA
D
LQSP
L
T
E
DG
KI
R
A
R
I
V
G
GY
Q
N
N
D
S
WL
D
RYNS
E
KT
FF
SG
IVD
A
D
LG
DLTT
L
SAG
----------
-
-
--Y
E
Y
QRI
D
VNS
PT
W
G
--
-
-G
LP
RW
N
T
DG--
--
S
S
NS
Y
D
RARSTAP
D
W
A
YND
KEI
N
KVF
M
T
--------
L
K
Q
R
F
A
DT
W
Q
A
T
L
N
A
T
H
SEV
E
F
D
S
--
KM
MY
V
D
AY
VNKA
D
GMLVG
P
YS
NYGPGFDY
VGGTGWNSGKRKVD
A
LDLFA
D
GIY
E
L
F
GR
Q
-
-
-
-
-
-
-
-
--
-
-
-
H
N
L
M
---------------
F
G
G
S
Y
S
K
QN
N
RYF
S
S
--------------------
W
A
--
---
-
---
-
--
N
IF-
PD
E
IGSFYNFNG
N
FP
Q
TDWSPQSL
A
QDD
T
T
HMKS
LYA
A
T
RV
T
LADP
L
H
L
I
L
G
A
R
YT
N
W
--
R
V
D
T
L
T
Y
------------
---------
-
-
-----
SMEK
N
HT
T
P
Y
AG
LV
F
D
I
N
DN
W
-
S
T
Y
A
SY
T
S
I
FQ
-----
P
---------
-
Q
NDR
---
D
S
S
G
KY
-
L
AP
I
T
GN
N
YE
L
G
L
K
SDWM
N
S
RL
TT
T
L
A
I
FR
IEQD
N
VAQ
STGTPIPG
S
N
G
E
T
A
Y
KA
V
--
D
GT
V
S
KGVE
F
E
LN
---
GAIT
D
N
WQ
L
T
F
G
A
T
RYI
AE
DNEG
N
AV
N
P
N
--
--
--------
L
P
R
T
TVK
MF
T
S
Y
RLP
V
M
P
--
E
LTVG
G
G
V
NW
Q
N
---
R
VYTDT
V
-
T
P
Y
GT
FR
A
EQ
GSY
A
L
VD
L
FT
RY
Q
V
T
K
----
N
F
S
L
Q
G
NVNNLFD
KT
Y
DTN
VEG
S
I
V
-------
---Y
GAPR
N
F
SI
T
G
T
YQ
F
fig|344610.3.peg.4616
Escherichia coli 53638 (21-729/729)
L
AG
CIA
L
ALLP
SA
A
F
AA
P
AT-
--
E
E
T
V
I
VE
G
S
A
---
T
AP
D
D
GE
----
NDYSVTSTSA
GTK
MQM
T
QR
D
I
PQS
V
T
I
VS
Q
Q
R
M
E
DQQ
LQ
T
L
G
E
VM
E
NT
L
G
I
S
---
-
-
-K
S
Q
A
D
S
D
R
A
LY
Y
S
RGF
-
----
Q
ID
N
Y
M
V
DGI
PT
YFESRWN
L
G
D
----
A
LS
D
MALF
ERVEV
V
RG
A
T
G
LM
T
G
T
G
N
P
S
A
A
INMV
R
K
H
A
T
S
REF
K
G
DVSA
EY
GS
WNKE
R
YVA
D
LQSP
L
T
E
DG
KI
R
A
R
I
V
G
GY
Q
N
N
D
S
WL
D
RYNS
E
KT
FF
SG
IVD
A
D
LG
DLTT
L
SAG
----------
-
-
--Y
E
Y
QRI
D
VNS
PT
W
G
--
-
-G
LP
RW
N
T
DG--
--
S
S
NS
Y
D
RARSTAP
D
W
A
YND
KEI
N
KVF
M
T
--------
L
K
Q
R
F
A
DT
W
Q
A
T
L
N
A
T
H
SEV
E
F
D
S
--
KM
MY
V
D
AY
VNKA
D
GMLVG
P
YS
NYGPGFDY
VGGTGWNSGKRKVD
A
LDLFA
D
GIY
E
L
F
GR
Q
-
-
-
-
-
-
-
-
--
-
-
-
H
N
L
M
---------------
F
G
G
S
Y
S
K
QN
N
RYF
S
S
--------------------
W
A
--
---
-
---
-
--
N
IF-
PD
E
IGSFYNFNG
N
FP
Q
TDWSPQSL
A
QDD
T
T
HMKS
LYA
A
T
RV
T
LADP
L
H
L
I
L
G
A
R
YT
N
W
--
R
V
D
T
L
T
Y
------------
---------
-
-
-----
SMEK
N
HT
T
P
Y
AG
LV
F
D
I
N
DN
W
-
S
T
Y
A
SY
T
S
I
FQ
-----
P
---------
-
Q
NDR
---
D
S
S
G
KY
-
L
AP
I
T
GN
N
YE
L
G
L
K
SDWM
N
S
RL
TT
T
L
A
I
FR
IEQD
N
VAQ
STGTPIPG
S
N
G
E
T
A
Y
KA
V
--
D
GT
V
S
KGVE
F
E
LN
---
GAIT
D
N
WQ
L
T
F
G
A
T
RYI
AE
DNEG
N
AV
N
P
N
--
--
--------
L
P
R
T
TVK
MF
T
S
Y
RLP
V
M
P
--
E
LTVG
G
G
V
NW
Q
N
---
R
VYTDT
V
-
T
P
Y
GT
FR
A
EQ
GSY
A
L
VD
L
FT
RY
Q
V
T
K
----
N
F
S
L
Q
G
NVNNLFD
KT
Y
DTN
VEG
S
I
V
-------
---Y
GAPR
N
F
SI
T
G
T
YQ
F
fig|344610.7.peg.542
Escherichia coli 53638 (21-729/729)
L
AG
CIA
L
ALLP
SA
A
F
AA
P
AT-
--
E
E
T
V
I
VE
G
S
A
---
T
AP
D
D
GE
----
NDYSVTSTSA
GTK
MQM
T
QR
D
I
PQS
V
T
I
VS
Q
Q
R
M
E
DQQ
LQ
T
L
G
E
VM
E
NT
L
G
I
S
---
-
-
-K
S
Q
A
D
S
D
R
A
LY
Y
S
RGF
-
----
Q
ID
N
Y
M
V
DGI
PT
YFESRWN
L
G
D
----
A
LS
D
MALF
ERVEV
V
RG
A
T
G
LM
T
G
T
G
N
P
S
A
A
INMV
R
K
H
A
T
S
REF
K
G
DVSA
EY
GS
WNKE
R
YVA
D
LQSP
L
T
E
DG
KI
R
A
R
I
V
G
GY
Q
N
N
D
S
WL
D
RYNS
E
KT
FF
SG
IVD
A
D
LG
DLTT
L
SAG
----------
-
-
--Y
E
Y
QRI
D
VNS
PT
W
G
--
-
-G
LP
RW
N
T
DG--
--
S
S
NS
Y
D
RARSTAP
D
W
A
YND
KEI
N
KVF
M
T
--------
L
K
Q
R
F
A
DT
W
Q
A
T
L
N
A
T
H
SEV
E
F
D
S
--
KM
MY
V
D
AY
VNKA
D
GMLVG
P
YS
NYGPGFDY
VGGTGWNSGKRKVD
A
LDLFA
D
GIY
E
L
F
GR
Q
-
-
-
-
-
-
-
-
--
-
-
-
H
N
L
M
---------------
F
G
G
S
Y
S
K
QN
N
RYF
S
S
--------------------
W
A
--
---
-
---
-
--
N
IF-
PD
E
IGSFYNFNG
N
FP
Q
TDWSPQSL
A
QDD
T
T
HMKS
LYA
A
T
RV
T
LADP
L
H
L
I
L
G
A
R
YT
N
W
--
R
V
D
T
L
T
Y
------------
---------
-
-
-----
SMEK
N
HT
T
P
Y
AG
LV
F
D
I
N
DN
W
-
S
T
Y
A
SY
T
S
I
FQ
-----
P
---------
-
Q
NDR
---
D
S
S
G
KY
-
L
AP
I
T
GN
N
YE
L
G
L
K
SDWM
N
S
RL
TT
T
L
A
I
FR
IEQD
N
VAQ
STGTPIPG
S
N
G
E
T
A
Y
KA
V
--
D
GT
V
S
KGVE
F
E
LN
---
GAIT
D
N
WQ
L
T
F
G
A
T
RYI
AE
DNEG
N
AV
N
P
N
--
--
--------
L
P
R
T
TVK
MF
T
S
Y
RLP
V
M
P
--
E
LTVG
G
G
V
NW
Q
N
---
R
VYTDT
V
-
T
P
Y
GT
FR
A
EQ
GSY
A
L
VD
L
FT
RY
Q
V
T
K
----
N
F
S
L
Q
G
NVNNLFD
KT
Y
DTN
VEG
S
I
V
-------
---Y
GAPR
N
F
SI
T
G
T
YQ
F
fig|481805.3.peg.2685
Escherichia coli ATCC 8739 (21-729/729)
L
AG
CIA
L
ALLP
SA
A
F
AA
P
AT-
--
E
E
T
V
I
VE
G
S
A
---
T
AP
D
D
GE
----
NDYSVTSTSA
GTK
MQM
T
QR
D
I
PQS
V
T
I
VS
Q
Q
R
M
E
DQQ
LQ
T
L
G
E
VM
E
NT
L
G
I
S
---
-
-
-K
S
Q
A
D
S
D
R
A
LY
Y
S
RGF
-
----
Q
ID
N
Y
M
V
DGI
PT
YFESRWN
L
G
D
----
A
LS
D
MALF
ERVEV
V
RG
A
T
G
LM
T
G
T
G
N
P
S
A
A
INMV
R
K
H
A
T
S
REF
K
G
DVSA
EY
GS
WNKE
R
YVA
D
LQSP
L
T
E
DG
KI
R
A
R
I
V
G
GY
Q
N
N
D
S
WL
D
RYNS
E
KT
FF
SG
IVD
A
D
LG
DLTT
L
SAG
----------
-
-
--Y
E
Y
QRI
D
VNS
PT
W
G
--
-
-G
LP
RW
N
T
DG--
--
S
S
NS
Y
D
RARSTAP
D
W
A
YND
KEI
N
KVF
M
T
--------
L
K
Q
R
F
A
DT
W
Q
A
T
L
N
A
T
H
SEV
E
F
D
S
--
KM
MY
V
D
AY
VNKA
D
GMLVG
P
YS
NYGPGFDY
VGGTGWNSGKRKVD
A
LDLFA
D
GIY
E
L
F
GR
Q
-
-
-
-
-
-
-
-
--
-
-
-
H
N
L
M
---------------
F
G
G
S
Y
S
K
QN
N
RYF
S
S
--------------------
W
A
--
---
-
---
-
--
N
IF-
PD
E
IGSFYNFNG
N
FP
Q
TDWSPQSL
A
QDD
T
T
HMKS
LYA
A
T
RV
T
LADP
L
H
L
I
L
G
A
R
YT
N
W
--
R
V
D
T
L
T
Y
------------
---------
-
-
-----
SMEK
N
HT
T
P
Y
AG
LV
F
D
I
N
DN
W
-
S
T
Y
A
SY
T
S
I
FQ
-----
P
---------
-
Q
NDR
---
D
S
S
G
KY
-
L
AP
I
T
GN
N
YE
L
G
L
K
SDWM
N
S
RL
TT
T
L
A
I
FR
IEQD
N
VAQ
STGTPIPG
S
N
G
E
T
A
Y
KA
V
--
D
GT
V
S
KGVE
F
E
LN
---
GAIT
D
N
WQ
L
T
F
G
A
T
RYI
AE
DNEG
N
AV
N
P
N
--
--
--------
L
P
R
T
TVK
MF
T
S
Y
RLP
V
M
P
--
E
LTVG
G
G
V
NW
Q
N
---
R
VYTDT
V
-
T
P
Y
GT
FR
A
EQ
GSY
A
L
VD
L
FT
RY
Q
V
T
K
----
N
F
S
L
Q
G
NVNNLFD
KT
Y
DTN
VEG
S
I
V
-------
---Y
GAPR
N
F
SI
T
G
T
YQ
F
fig|481805.6.peg.2672
Escherichia coli ATCC 8739 (21-729/729)
L
AG
CIA
L
ALLP
SA
A
F
AA
P
AT-
--
E
E
T
V
I
VE
G
S
A
---
T
AP
D
D
GE
----
NDYSVTSTSA
GTK
MQM
T
QR
D
I
PQS
V
T
I
VS
Q
Q
R
M
E
DQQ
LQ
T
L
G
E
VM
E
NT
L
G
I
S
---
-
-
-K
S
Q
A
D
S
D
R
A
LY
Y
S
RGF
-
----
Q
ID
N
Y
M
V
DGI
PT
YFESRWN
L
G
D
----
A
LS
D
MALF
ERVEV
V
RG
A
T
G
LM
T
G
T
G
N
P
S
A
A
INMV
R
K
H
A
T
S
REF
K
G
DVSA
EY
GS
WNKE
R
YVA
D
LQSP
L
T
E
DG
KI
R
A
R
I
V
G
GY
Q
N
N
D
S
WL
D
RYNS
E
KT
FF
SG
IVD
A
D
LG
DLTT
L
SAG
----------
-
-
--Y
E
Y
QRI
D
VNS
PT
W
G
--
-
-G
LP
RW
N
T
DG--
--
S
S
NS
Y
D
RARSTAP
D
W
A
YND
KEI
N
KVF
M
T
--------
L
K
Q
R
F
A
DT
W
Q
A
T
L
N
A
T
H
SEV
E
F
D
S
--
KM
MY
V
D
AY
VNKA
D
GMLVG
P
YS
NYGPGFDY
VGGTGWNSGKRKVD
A
LDLFA
D
GIY
E
L
F
GR
Q
-
-
-
-
-
-
-
-
--
-
-
-
H
N
L
M
---------------
F
G
G
S
Y
S
K
QN
N
RYF
S
S
--------------------
W
A
--
---
-
---
-
--
N
IF-
PD
E
IGSFYNFNG
N
FP
Q
TDWSPQSL
A
QDD
T
T
HMKS
LYA
A
T
RV
T
LADP
L
H
L
I
L
G
A
R
YT
N
W
--
R
V
D
T
L
T
Y
------------
---------
-
-
-----
SMEK
N
HT
T
P
Y
AG
LV
F
D
I
N
DN
W
-
S
T
Y
A
SY
T
S
I
FQ
-----
P
---------
-
Q
NDR
---
D
S
S
G
KY
-
L
AP
I
T
GN
N
YE
L
G
L
K
SDWM
N
S
RL
TT
T
L
A
I
FR
IEQD
N
VAQ
STGTPIPG
S
N
G
E
T
A
Y
KA
V
--
D
GT
V
S
KGVE
F
E
LN
---
GAIT
D
N
WQ
L
T
F
G
A
T
RYI
AE
DNEG
N
AV
N
P
N
--
--
--------
L
P
R
T
TVK
MF
T
S
Y
RLP
V
M
P
--
E
LTVG
G
G
V
NW
Q
N
---
R
VYTDT
V
-
T
P
Y
GT
FR
A
EQ
GSY
A
L
VD
L
FT
RY
Q
V
T
K
----
N
F
S
L
Q
G
NVNNLFD
KT
Y
DTN
VEG
S
I
V
-------
---Y
GAPR
N
F
SI
T
G
T
YQ
F
fig|413997.3.peg.1156
Escherichia coli B str. REL606 (21-729/729)
L
AG
CIA
L
ALLP
SA
A
F
AA
P
AT-
--
E
E
T
V
I
VE
G
S
A
---
T
AP
D
D
GE
----
NDYSVTSTSA
GTK
MQM
T
QR
D
I
PQS
V
T
I
VS
Q
Q
R
M
E
DQQ
LQ
T
L
G
E
VM
E
NT
L
G
I
S
---
-
-
-K
S
Q
A
D
S
D
R
A
LY
Y
S
RGF
-
----
Q
ID
N
Y
M
V
DGI
PT
YFESRWN
L
G
D
----
A
LS
D
MALF
ERVEV
V
RG
A
T
G
LM
T
G
T
G
N
P
S
A
A
INMV
R
K
H
A
T
S
REF
K
G
DVSA
EY
GS
WNKE
R
YVA
D
LQSP
L
T
E
DG
KI
R
A
R
I
V
G
GY
Q
N
N
D
S
WL
D
RYNS
E
KT
FF
SG
IVD
A
D
LG
DLTT
L
SAG
----------
-
-
--Y
E
Y
QRI
D
VNS
PT
W
G
--
-
-G
LP
RW
N
T
DG--
--
S
S
NS
Y
D
RARSTAP
D
W
A
YND
KEI
N
KVF
M
T
--------
L
K
Q
R
F
A
DT
W
Q
A
T
L
N
A
T
H
SEV
E
F
D
S
--
KM
MY
V
D
AY
VNKA
D
GMLVG
P
YS
NYGPGFDY
VGGTGWNSGKRKVD
A
LDLFA
D
GIY
E
L
F
GR
Q
-
-
-
-
-
-
-
-
--
-
-
-
H
N
L
M
---------------
F
G
G
S
Y
S
K
QN
N
RYF
S
S
--------------------
W
A
--
---
-
---
-
--
N
IF-
PD
E
IGSFYNFNG
N
FP
Q
TDWSPQSL
A
QDD
T
T
HMKS
LYA
A
T
RV
T
LADP
L
H
L
I
L
G
A
R
YT
N
W
--
R
V
D
T
L
T
Y
------------
---------
-
-
-----
SMEK
N
HT
T
P
Y
AG
LV
F
D
I
N
DN
W
-
S
T
Y
A
SY
T
S
I
FQ
-----
P
---------
-
Q
NDR
---
D
S
S
G
KY
-
L
AP
I
T
GN
N
YE
L
G
L
K
SDWM
N
S
RL
TT
T
L
A
I
FR
IEQD
N
VAQ
STGTPIPG
S
N
G
E
T
A
Y
KA
V
--
D
GT
V
S
KGVE
F
E
LN
---
GAIT
D
N
WQ
L
T
F
G
A
T
RYI
AE
DNEG
N
AV
N
P
N
--
--
--------
L
P
R
T
TVK
MF
T
S
Y
RLP
V
M
P
--
E
LTVG
G
G
V
NW
Q
N
---
R
VYTDT
V
-
T
P
Y
GT
FR
A
EQ
GSY
A
L
VD
L
FT
RY
Q
V
T
K
----
N
F
S
L
Q
G
NVNNLFD
KT
Y
DTN
VEG
S
I
V
-------
---Y
GAPR
N
F
SI
T
G
T
YQ
F
fig|511693.5.peg.1185
Escherichia coli BL21 (21-729/729)
L
AG
CIA
L
ALLP
SA
A
F
AA
P
AT-
--
E
E
T
V
I
VE
G
S
A
---
T
AP
D
D
GE
----
NDYSVTSTSA
GTK
MQM
T
QR
D
I
PQS
V
T
I
VS
Q
Q
R
M
E
DQQ
LQ
T
L
G
E
VM
E
NT
L
G
I
S
---
-
-
-K
S
Q
A
D
S
D
R
A
LY
Y
S
RGF
-
----
Q
ID
N
Y
M
V
DGI
PT
YFESRWN
L
G
D
----
A
LS
D
MALF
ERVEV
V
RG
A
T
G
LM
T
G
T
G
N
P
S
A
A
INMV
R
K
H
A
T
S
REF
K
G
DVSA
EY
GS
WNKE
R
YVA
D
LQSP
L
T
E
DG
KI
R
A
R
I
V
G
GY
Q
N
N
D
S
WL
D
RYNS
E
KT
FF
SG
IVD
A
D
LG
DLTT
L
SAG
----------
-
-
--Y
E
Y
QRI
D
VNS
PT
W
G
--
-
-G
LP
RW
N
T
DG--
--
S
S
NS
Y
D
RARSTAP
D
W
A
YND
KEI
N
KVF
M
T
--------
L
K
Q
R
F
A
DT
W
Q
A
T
L
N
A
T
H
SEV
E
F
D
S
--
KM
MY
V
D
AY
VNKA
D
GMLVG
P
YS
NYGPGFDY
VGGTGWNSGKRKVD
A
LDLFA
D
GIY
E
L
F
GR
Q
-
-
-
-
-
-
-
-
--
-
-
-
H
N
L
M
---------------
F
G
G
S
Y
S
K
QN
N
RYF
S
S
--------------------
W
A
--
---
-
---
-
--
N
IF-
PD
E
IGSFYNFNG
N
FP
Q
TDWSPQSL
A
QDD
T
T
HMKS
LYA
A
T
RV
T
LADP
L
H
L
I
L
G
A
R
YT
N
W
--
R
V
D
T
L
T
Y
------------
---------
-
-
-----
SMEK
N
HT
T
P
Y
AG
LV
F
D
I
N
DN
W
-
S
T
Y
A
SY
T
S
I
FQ
-----
P
---------
-
Q
NDR
---
D
S
S
G
KY
-
L
AP
I
T
GN
N
YE
L
G
L
K
SDWM
N
S
RL
TT
T
L
A
I
FR
IEQD
N
VAQ
STGTPIPG
S
N
G
E
T
A
Y
KA
V
--
D
GT
V
S
KGVE
F
E
LN
---
GAIT
D
N
WQ
L
T
F
G
A
T
RYI
AE
DNEG
N
AV
N
P
N
--
--
--------
L
P
R
T
TVK
MF
T
S
Y
RLP
V
M
P
--
E
LTVG
G
G
V
NW
Q
N
---
R
VYTDT
V
-
T
P
Y
GT
FR
A
EQ
GSY
A
L
VD
L
FT
RY
Q
V
T
K
----
N
F
S
L
Q
G
NVNNLFD
KT
Y
DTN
VEG
S
I
V
-------
---Y
GAPR
N
F
SI
T
G
T
YQ
F
fig|469008.4.peg.2580
Escherichia coli BL21(DE3) (21-729/729)
L
AG
CIA
L
ALLP
SA
A
F
AA
P
AT-
--
E
E
T
V
I
VE
G
S
A
---
T
AP
D
D
GE
----
NDYSVTSTSA
GTK
MQM
T
QR
D
I
PQS
V
T
I
VS
Q
Q
R
M
E
DQQ
LQ
T
L
G
E
VM
E
NT
L
G
I
S
---
-
-
-K
S
Q
A
D
S
D
R
A
LY
Y
S
RGF
-
----
Q
ID
N
Y
M
V
DGI
PT
YFESRWN
L
G
D
----
A
LS
D
MALF
ERVEV
V
RG
A
T
G
LM
T
G
T
G
N
P
S
A
A
INMV
R
K
H
A
T
S
REF
K
G
DVSA
EY
GS
WNKE
R
YVA
D
LQSP
L
T
E
DG
KI
R
A
R
I
V
G
GY
Q
N
N
D
S
WL
D
RYNS
E
KT
FF
SG
IVD
A
D
LG
DLTT
L
SAG
----------
-
-
--Y
E
Y
QRI
D
VNS
PT
W
G
--
-
-G
LP
RW
N
T
DG--
--
S
S
NS
Y
D
RARSTAP
D
W
A
YND
KEI
N
KVF
M
T
--------
L
K
Q
R
F
A
DT
W
Q
A
T
L
N
A
T
H
SEV
E
F
D
S
--
KM
MY
V
D
AY
VNKA
D
GMLVG
P
YS
NYGPGFDY
VGGTGWNSGKRKVD
A
LDLFA
D
GIY
E
L
F
GR
Q
-
-
-
-
-
-
-
-
--
-
-
-
H
N
L
M
---------------
F
G
G
S
Y
S
K
QN
N
RYF
S
S
--------------------
W
A
--
---
-
---
-
--
N
IF-
PD
E
IGSFYNFNG
N
FP
Q
TDWSPQSL
A
QDD
T
T
HMKS
LYA
A
T
RV
T
LADP
L
H
L
I
L
G
A
R
YT
N
W
--
R
V
D
T
L
T
Y
------------
---------
-
-
-----
SMEK
N
HT
T
P
Y
AG
LV
F
D
I
N
DN
W
-
S
T
Y
A
SY
T
S
I
FQ
-----
P
---------
-
Q
NDR
---
D
S
S
G
KY
-
L
AP
I
T
GN
N
YE
L
G
L
K
SDWM
N
S
RL
TT
T
L
A
I
FR
IEQD
N
VAQ
STGTPIPG
S
N
G
E
T
A
Y
KA
V
--
D
GT
V
S
KGVE
F
E
LN
---
GAIT
D
N
WQ
L
T
F
G
A
T
RYI
AE
DNEG
N
AV
N
P
N
--
--
--------
L
P
R
T
TVK
MF
T
S
Y
RLP
V
M
P
--
E
LTVG
G
G
V
NW
Q
N
---
R
VYTDT
V
-
T
P
Y
GT
FR
A
EQ
GSY
A
L
VD
L
FT
RY
Q
V
T
K
----
N
F
S
L
Q
G
NVNNLFD
KT
Y
DTN
VEG
S
I
V
-------
---Y
GAPR
N
F
SI
T
G
T
YQ
F
fig|331112.3.peg.1141
Escherichia coli HS (21-729/729)
L
AG
CIA
L
ALLP
SA
A
F
AA
P
AT-
--
E
E
T
V
I
VE
G
S
A
---
T
AP
D
D
GE
----
NDYSVTSTSA
GTK
MQM
T
QR
D
I
PQS
V
T
I
VS
Q
Q
R
M
E
DQQ
LQ
T
L
G
E
VM
E
NT
L
G
I
S
---
-
-
-K
S
Q
A
D
S
D
R
A
LY
Y
S
RGF
-
----
Q
ID
N
Y
M
V
DGI
PT
YFESRWN
L
G
D
----
A
LS
D
MALF
ERVEV
V
RG
A
T
G
LM
T
G
T
G
N
P
S
A
A
INMV
R
K
H
A
T
S
REF
K
G
DVSA
EY
GS
WNKE
R
YVA
D
LQSP
L
T
E
DG
KI
R
A
R
I
V
G
GY
Q
N
N
D
S
WL
D
RYNS
E
KT
FF
SG
IVD
A
D
LG
DLTT
L
SAG
----------
-
-
--Y
E
Y
QRI
D
VNS
PT
W
G
--
-
-G
LP
RW
N
T
DG--
--
S
S
NS
Y
D
RARSTAP
D
W
A
YND
KEI
N
KVF
M
T
--------
L
K
Q
R
F
A
DT
W
Q
A
T
L
N
A
T
H
SEV
E
F
D
S
--
KM
MY
V
D
AY
VNKA
D
GMLVG
P
YS
NYGPGFDY
VGGTGWNSGKRKVD
A
LDLFA
D
GIY
E
L
F
GR
Q
-
-
-
-
-
-
-
-
--
-
-
-
H
N
L
M
---------------
F
G
G
S
Y
S
K
QN
N
RYF
S
S
--------------------
W
A
--
---
-
---
-
--
N
IF-
PD
E
IGSFYNFNG
N
FP
Q
TDWSPQSL
A
QDD
T
T
HMKS
LYA
A
T
RV
T
LADP
L
H
L
I
L
G
A
R
YT
N
W
--
R
V
D
T
L
T
Y
------------
---------
-
-
-----
SMEK
N
HT
T
P
Y
AG
LV
F
D
I
N
DN
W
-
S
T
Y
A
SY
T
S
I
FQ
-----
P
---------
-
Q
NDR
---
D
S
S
G
KY
-
L
AP
I
T
GN
N
YE
L
G
L
K
SDWM
N
S
RL
TT
T
L
A
I
FR
IEQD
N
VAQ
STGTPIPG
S
N
G
E
T
A
Y
KA
V
--
D
GT
V
S
KGVE
F
E
LN
---
GAIT
D
N
WQ
L
T
F
G
A
T
RYI
AE
DNEG
N
AV
N
P
N
--
--
--------
L
P
R
T
TVK
MF
T
S
Y
RLP
V
M
P
--
E
LTVG
G
G
V
NW
Q
N
---
R
VYTDT
V
-
T
P
Y
GT
FR
A
EQ
GSY
A
L
VD
L
FT
RY
Q
V
T
K
----
N
F
S
L
Q
G
NVNNLFD
KT
Y
DTN
VEG
S
I
V
-------
---Y
GAPR
N
F
SI
T
G
T
YQ
F
fig|331112.6.peg.1190
Escherichia coli HS (21-729/729)
L
AG
CIA
L
ALLP
SA
A
F
AA
P
AT-
--
E
E
T
V
I
VE
G
S
A
---
T
AP
D
D
GE
----
NDYSVTSTSA
GTK
MQM
T
QR
D
I
PQS
V
T
I
VS
Q
Q
R
M
E
DQQ
LQ
T
L
G
E
VM
E
NT
L
G
I
S
---
-
-
-K
S
Q
A
D
S
D
R
A
LY
Y
S
RGF
-
----
Q
ID
N
Y
M
V
DGI
PT
YFESRWN
L
G
D
----
A
LS
D
MALF
ERVEV
V
RG
A
T
G
LM
T
G
T
G
N
P
S
A
A
INMV
R
K
H
A
T
S
REF
K
G
DVSA
EY
GS
WNKE
R
YVA
D
LQSP
L
T
E
DG
KI
R
A
R
I
V
G
GY
Q
N
N
D
S
WL
D
RYNS
E
KT
FF
SG
IVD
A
D
LG
DLTT
L
SAG
----------
-
-
--Y
E
Y
QRI
D
VNS
PT
W
G
--
-
-G
LP
RW
N
T
DG--
--
S
S
NS
Y
D
RARSTAP
D
W
A
YND
KEI
N
KVF
M
T
--------
L
K
Q
R
F
A
DT
W
Q
A
T
L
N
A
T
H
SEV
E
F
D
S
--
KM
MY
V
D
AY
VNKA
D
GMLVG
P
YS
NYGPGFDY
VGGTGWNSGKRKVD
A
LDLFA
D
GIY
E
L
F
GR
Q
-
-
-
-
-
-
-
-
--
-
-
-
H
N
L
M
---------------
F
G
G
S
Y
S
K
QN
N
RYF
S
S
--------------------
W
A
--
---
-
---
-
--
N
IF-
PD
E
IGSFYNFNG
N
FP
Q
TDWSPQSL
A
QDD
T
T
HMKS
LYA
A
T
RV
T
LADP
L
H
L
I
L
G
A
R
YT
N
W
--
R
V
D
T
L
T
Y
------------
---------
-
-
-----
SMEK
N
HT
T
P
Y
AG
LV
F
D
I
N
DN
W
-
S
T
Y
A
SY
T
S
I
FQ
-----
P
---------
-
Q
NDR
---
D
S
S
G
KY
-
L
AP
I
T
GN
N
YE
L
G
L
K
SDWM
N
S
RL
TT
T
L
A
I
FR
IEQD
N
VAQ
STGTPIPG
S
N
G
E
T
A
Y
KA
V
--
D
GT
V
S
KGVE
F
E
LN
---
GAIT
D
N
WQ
L
T
F
G
A
T
RYI
AE
DNEG
N
AV
N
P
N
--
--
--------
L
P
R
T
TVK
MF
T
S
Y
RLP
V
M
P
--
E
LTVG
G
G
V
NW
Q
N
---
R
VYTDT
V
-
T
P
Y
GT
FR
A
EQ
GSY
A
L
VD
L
FT
RY
Q
V
T
K
----
N
F
S
L
Q
G
NVNNLFD
KT
Y
DTN
VEG
S
I
V
-------
---Y
GAPR
N
F
SI
T
G
T
YQ
F
fig|749537.3.peg.2362
Escherichia coli MS 115-1 (21-729/729)
L
AG
CIA
L
ALLP
SA
A
F
AA
P
AT-
--
E
E
T
V
I
VE
G
S
A
---
T
AP
D
D
GE
----
NDYSVTSTSA
GTK
MQM
T
QR
D
I
PQS
V
T
I
VS
Q
Q
R
M
E
DQQ
LQ
T
L
G
E
VM
E
NT
L
G
I
S
---
-
-
-K
S
Q
A
D
S
D
R
A
LY
Y
S
RGF
-
----
Q
ID
N
Y
M
V
DGI
PT
YFESRWN
L
G
D
----
A
LS
D
MALF
ERVEV
V
RG
A
T
G
LM
T
G
T
G
N
P
S
A
A
INMV
R
K
H
A
T
S
REF
K
G
DVSA
EY
GS
WNKE
R
YVA
D
LQSP
L
T
E
DG
KI
R
A
R
I
V
G
GY
Q
N
N
D
S
WL
D
RYNS
E
KT
FF
SG
IVD
A
D
LG
DLTT
L
SAG
----------
-
-
--Y
E
Y
QRI
D
VNS
PT
W
G
--
-
-G
LP
RW
N
T
DG--
--
S
S
NS
Y
D
RARSTAP
D
W
A
YND
KEI
N
KVF
M
T
--------
L
K
Q
R
F
A
DT
W
Q
A
T
L
N
A
T
H
SEV
E
F
D
S
--
KM
MY
V
D
AY
VNKA
D
GMLVG
P
YS
NYGPGFDY
VGGTGWNSGKRKVD
A
LDLFA
D
GIY
E
L
F
GR
Q
-
-
-
-
-
-
-
-
--
-
-
-
H
N
L
M
---------------
F
G
G
S
Y
S
K
QN
N
RYF
S
S
--------------------
W
A
--
---
-
---
-
--
N
IF-
PD
E
IGSFYNFNG
N
FP
Q
TDWSPQSL
A
QDD
T
T
HMKS
LYA
A
T
RV
T
LADP
L
H
L
I
L
G
A
R
YT
N
W
--
R
V
D
T
L
T
Y
------------
---------
-
-
-----
SMEK
N
HT
T
P
Y
AG
LV
F
D
I
N
DN
W
-
S
T
Y
A
SY
T
S
I
FQ
-----
P
---------
-
Q
NDR
---
D
S
S
G
KY
-
L
AP
I
T
GN
N
YE
L
G
L
K
SDWM
N
S
RL
TT
T
L
A
I
FR
IEQD
N
VAQ
STGTPIPG
S
N
G
E
T
A
Y
KA
V
--
D
GT
V
S
KGVE
F
E
LN
---
GAIT
D
N
WQ
L
T
F
G
A
T
RYI
AE
DNEG
N
AV
N
P
N
--
--
--------
L
P
R
T
TVK
MF
T
S
Y
RLP
V
M
P
--
E
LTVG
G
G
V
NW
Q
N
---
R
VYTDT
V
-
T
P
Y
GT
FR
A
EQ
GSY
A
L
VD
L
FT
RY
Q
V
T
K
----
N
F
S
L
Q
G
NVNNLFD
KT
Y
DTN
VEG
S
I
V
-------
---Y
GAPR
N
F
SI
T
G
T
YQ
F
fig|679205.4.peg.4129
Escherichia coli MS 124-1 (21-729/729)
L
AG
CIA
L
ALLP
SA
A
F
AA
P
AT-
--
E
E
T
V
I
VE
G
S
A
---
T
AP
D
D
GE
----
NDYSVTSTSA
GTK
MQM
T
QR
D
I
PQS
V
T
I
VS
Q
Q
R
M
E
DQQ
LQ
T
L
G
E
VM
E
NT
L
G
I
S
---
-
-
-K
S
Q
A
D
S
D
R
A
LY
Y
S
RGF
-
----
Q
ID
N
Y
M
V
DGI
PT
YFESRWN
L
G
D
----
A
LS
D
MALF
ERVEV
V
RG
A
T
G
LM
T
G
T
G
N
P
S
A
A
INMV
R
K
H
A
T
S
REF
K
G
DVSA
EY
GS
WNKE
R
YVA
D
LQSP
L
T
E
DG
KI
R
A
R
I
V
G
GY
Q
N
N
D
S
WL
D
RYNS
E
KT
FF
SG
IVD
A
D
LG
DLTT
L
SAG
----------
-
-
--Y
E
Y
QRI
D
VNS
PT
W
G
--
-
-G
LP
RW
N
T
DG--
--
S
S
NS
Y
D
RARSTAP
D
W
A
YND
KEI
N
KVF
M
T
--------
L
K
Q
R
F
A
DT
W
Q
A
T
L
N
A
T
H
SEV
E
F
D
S
--
KM
MY
V
D
AY
VNKA
D
GMLVG
P
YS
NYGPGFDY
VGGTGWNSGKRKVD
A
LDLFA
D
GIY
E
L
F
GR
Q
-
-
-
-
-
-
-
-
--
-
-
-
H
N
L
M
---------------
F
G
G
S
Y
S
K
QN
N
RYF
S
S
--------------------
W
A
--
---
-
---
-
--
N
IF-
PD
E
IGSFYNFNG
N
FP
Q
TDWSPQSL
A
QDD
T
T
HMKS
LYA
A
T
RV
T
LADP
L
H
L
I
L
G
A
R
YT
N
W
--
R
V
D
T
L
T
Y
------------
---------
-
-
-----
SMEK
N
HT
T
P
Y
AG
LV
F
D
I
N
DN
W
-
S
T
Y
A
SY
T
S
I
FQ
-----
P
---------
-
Q
NDR
---
D
S
S
G
KY
-
L
AP
I
T
GN
N
YE
L
G
L
K
SDWM
N
S
RL
TT
T
L
A
I
FR
IEQD
N
VAQ
STGTPIPG
S
N
G
E
T
A
Y
KA
V
--
D
GT
V
S
KGVE
F
E
LN
---
GAIT
D
N
WQ
L
T
F
G
A
T
RYI
AE
DNEG
N
AV
N
P
N
--
--
--------
L
P
R
T
TVK
MF
T
S
Y
RLP
V
M
P
--
E
LTVG
G
G
V
NW
Q
N
---
R
VYTDT
V
-
T
P
Y
GT
FR
A
EQ
GSY
A
L
VD
L
FT
RY
Q
V
T
K
----
N
F
S
L
Q
G
NVNNLFD
KT
Y
DTN
VEG
S
I
V
-------
---Y
GAPR
N
F
SI
T
G
T
YQ
F
fig|749533.3.peg.630
Escherichia coli MS 84-1 (21-729/729)
L
AG
CIA
L
ALLP
SA
A
F
AA
P
AT-
--
E
E
T
V
I
VE
G
S
A
---
T
AP
D
D
GE
----
NDYSVTSTSA
GTK
MQM
T
QR
D
I
PQS
V
T
I
VS
Q
Q
R
M
E
DQQ
LQ
T
L
G
E
VM
E
NT
L
G
I
S
---
-
-
-K
S
Q
A
D
S
D
R
A
LY
Y
S
RGF
-
----
Q
ID
N
Y
M
V
DGI
PT
YFESRWN
L
G
D
----
A
LS
D
MALF
ERVEV
V
RG
A
T
G
LM
T
G
T
G
N
P
S
A
A
INMV
R
K
H
A
T
S
REF
K
G
DVSA
EY
GS
WNKE
R
YVA
D
LQSP
L
T
E
DG
KI
R
A
R
I
V
G
GY
Q
N
N
D
S
WL
D
RYNS
E
KT
FF
SG
IVD
A
D
LG
DLTT
L
SAG
----------
-
-
--Y
E
Y
QRI
D
VNS
PT
W
G
--
-
-G
LP
RW
N
T
DG--
--
S
S
NS
Y
D
RARSTAP
D
W
A
YND
KEI
N
KVF
M
T
--------
L
K
Q
R
F
A
DT
W
Q
A
T
L
N
A
T
H
SEV
E
F
D
S
--
KM
MY
V
D
AY
VNKA
D
GMLVG
P
YS
NYGPGFDY
VGGTGWNSGKRKVD
A
LDLFA
D
GIY
E
L
F
GR
Q
-
-
-
-
-
-
-
-
--
-
-
-
H
N
L
M
---------------
F
G
G
S
Y
S
K
QN
N
RYF
S
S
--------------------
W
A
--
---
-
---
-
--
N
IF-
PD
E
IGSFYNFNG
N
FP
Q
TDWSPQSL
A
QDD
T
T
HMKS
LYA
A
T
RV
T
LADP
L
H
L
I
L
G
A
R
YT
N
W
--
R
V
D
T
L
T
Y
------------
---------
-
-
-----
SMEK
N
HT
T
P
Y
AG
LV
F
D
I
N
DN
W
-
S
T
Y
A
SY
T
S
I
FQ
-----
P
---------
-
Q
NDR
---
D
S
S
G
KY
-
L
AP
I
T
GN
N
YE
L
G
L
K
SDWM
N
S
RL
TT
T
L
A
I
FR
IEQD
N
VAQ
STGTPIPG
S
N
G
E
T
A
Y
KA
V
--
D
GT
V
S
KGVE
F
E
LN
---
GAIT
D
N
WQ
L
T
F
G
A
T
RYI
AE
DNEG
N
AV
N
P
N
--
--
--------
L
P
R
T
TVK
MF
T
S
Y
RLP
V
M
P
--
E
LTVG
G
G
V
NW
Q
N
---
R
VYTDT
V
-
T
P
Y
GT
FR
A
EQ
GSY
A
L
VD
L
FT
RY
Q
V
T
K
----
N
F
S
L
Q
G
NVNNLFD
KT
Y
DTN
VEG
S
I
V
-------
---Y
GAPR
N
F
SI
T
G
T
YQ
F
fig|753642.3.peg.2210
Escherichia coli NC101 (21-729/729)
L
AG
CIA
L
ALLP
SA
A
F
AA
P
AT-
--
E
E
T
V
I
VE
G
S
A
---
T
AP
D
D
GE
----
NDYNVTSTSA
GTK
MQM
T
QR
D
I
PQS
V
T
I
VS
Q
Q
R
M
E
DQQ
LQ
T
L
G
E
VM
E
NT
L
G
I
S
---
-
-
-K
S
Q
A
D
S
D
R
A
LY
Y
S
RGF
-
----
Q
ID
N
Y
M
V
DGI
PT
YFESRWN
L
G
D
----
A
LS
D
MALF
ERVEV
V
RG
A
T
G
LM
T
G
T
G
N
P
S
A
A
INMV
R
K
H
A
T
S
REF
K
G
DVSA
EY
GS
WNKE
R
YVA
D
LQSP
L
T
E
DG
KI
R
A
R
I
V
G
GY
Q
N
N
D
S
WL
D
RYNS
E
KT
FF
SG
IVD
A
D
LG
DLTM
L
SAG
----------
-
-
--Y
E
Y
QRI
D
VNS
PT
W
G
--
-
-G
LP
RW
N
T
DG--
--
S
S
NS
Y
D
RARSTAP
D
W
A
YND
KEI
N
KVF
M
T
--------
L
K
Q
R
F
A
DT
W
Q
A
T
L
N
A
T
H
SEV
E
F
D
S
--
KM
MY
V
D
AY
VNKA
D
GMLVG
P
YS
NYGPGFDY
VGGTGWNSGKRKVD
A
LDLFA
D
GSY
E
L
F
GR
Q
-
-
-
-
-
-
-
-
--
-
-
-
H
N
L
M
---------------
F
G
G
S
Y
S
K
QN
N
RYF
S
S
--------------------
W
A
--
---
-
---
-
--
N
IF-
PD
E
IGSFYNFNG
N
FP
Q
TDWSPQSL
A
QDD
T
T
HMKS
LYA
A
T
RV
T
LADP
L
H
L
I
L
G
A
R
YT
N
W
--
R
V
D
T
L
T
Y
------------
---------
-
-
-----
SMEK
N
HT
T
P
Y
AG
LV
F
D
I
N
DN
W
-
S
T
Y
A
SY
T
S
I
FQ
-----
P
---------
-
Q
NDR
---
D
S
S
G
KY
-
L
T
P
I
T
GN
N
YE
L
G
L
K
SDWM
N
S
RL
TT
T
L
A
I
FR
IEQD
N
VAQ
STGTPIPG
S
N
G
E
T
A
Y
KA
V
--
D
GT
V
S
KGVE
F
E
LN
---
GAIT
D
N
WQ
L
T
F
G
A
T
RYI
AE
DNEG
N
AV
N
P
N
--
--
--------
L
P
R
T
TVK
MF
T
S
Y
RLP
V
M
P
--
E
LTVG
G
G
V
NW
Q
N
---
R
VYTDT
V
-
T
P
Y
GT
FR
A
EQ
GSY
A
L
VD
L
FT
RY
Q
V
T
K
----
N
F
S
L
Q
G
NVNNLFD
KT
Y
DTN
VEG
S
I
V
-------
---Y
GAPR
N
F
SI
T
G
T
YQ
F
fig|656440.3.peg.1016
Escherichia coli TA206 (21-729/729)
L
AG
CIA
L
ALLP
SA
A
F
AA
P
AT-
--
E
E
T
V
I
VE
G
S
A
---
T
AP
D
D
GE
----
NDYNVTSTSA
GTK
MQM
T
QR
D
I
PQS
V
T
I
VS
Q
Q
R
M
E
DQQ
LQ
T
L
G
E
VM
E
NT
L
G
I
S
---
-
-
-K
S
Q
A
D
S
D
R
A
LY
Y
S
RGF
-
----
Q
ID
N
Y
M
V
DGI
PT
YFESRWN
L
G
D
----
A
LS
D
MALF
ERVEV
V
RG
A
T
G
LM
T
G
T
G
N
P
S
A
A
INMV
R
K
H
A
T
S
REF
K
G
DVSA
EY
GS
WNKE
R
YVA
D
LQSP
L
T
E
DG
KI
R
A
R
I
V
G
GY
Q
N
N
D
S
WL
D
RYNS
E
KT
FF
SG
IVD
A
D
LG
DLTM
L
SAG
----------
-
-
--Y
E
Y
QRI
D
VNS
PT
W
G
--
-
-G
LP
RW
N
T
DG--
--
S
S
NS
Y
D
RARSTAP
D
W
A
YND
KEI
N
KVF
M
T
--------
L
K
Q
R
F
A
DT
W
Q
A
T
L
N
A
T
H
SEV
E
F
D
S
--
KM
MY
V
D
AY
VNKA
D
GMLVG
P
YS
NYGPGFDY
VGGTGWNSGKRKVD
A
LDLFA
D
GSY
E
L
F
GR
Q
-
-
-
-
-
-
-
-
--
-
-
-
H
N
L
M
---------------
F
G
G
S
Y
S
K
QN
N
RYF
S
S
--------------------
W
A
--
---
-
---
-
--
N
IF-
PD
E
IGSFYNFNG
N
FP
Q
TDWSPQSL
A
QDD
T
T
HMKS
LYA
A
T
RV
T
LADP
L
H
L
I
L
G
A
R
YT
N
W
--
R
V
D
T
L
T
Y
------------
---------
-
-
-----
SMEK
N
HT
T
P
Y
AG
LV
F
D
I
N
DN
W
-
S
T
Y
A
SY
T
S
I
FQ
-----
P
---------
-
Q
NDR
---
D
S
S
G
KY
-
L
T
P
I
T
GN
N
YE
L
G
L
K
SDWM
N
S
RL
TT
T
L
A
I
FR
IEQD
N
VAQ
STGTPIPG
S
N
G
E
T
A
Y
KA
V
--
D
GT
V
S
KGVE
F
E
LN
---
GAIT
D
N
WQ
L
T
F
G
A
T
RYI
AE
DNEG
N
AV
N
P
N
--
--
--------
L
P
R
T
TVK
MF
T
S
Y
RLP
V
M
P
--
E
LTVG
G
G
V
NW
Q
N
---
R
VYTDT
V
-
T
P
Y
GT
FR
A
EQ
GSY
A
L
VD
L
FT
RY
Q
V
T
K
----
N
F
S
L
Q
G
NVNNLFD
KT
Y
DTN
VEG
S
I
V
-------
---Y
GAPR
N
F
SI
T
G
T
YQ
F
fig|585397.7.peg.1256
Escherichia coli ED1a (21-729/729)
L
AG
CIA
L
ALLP
SA
A
F
AA
P
VT-
--
E
E
T
V
I
VE
G
S
A
---
T
AP
D
D
GE
----
NDYNVTSTSA
GTK
MQM
T
QR
D
I
PQS
V
T
I
VS
Q
Q
R
M
E
DQQ
LQ
T
L
G
E
VM
E
NT
L
G
I
S
---
-
-
-K
S
Q
A
D
S
D
R
A
LY
Y
S
RGF
-
----
Q
ID
N
Y
M
V
DGI
PT
YFESRWN
L
G
D
----
A
LS
D
MALF
ERVEV
V
RG
A
T
G
LM
T
G
T
G
N
P
S
A
A
INMV
R
K
H
A
T
S
REF
K
G
DVSA
EY
GS
WNKE
R
YVA
D
LQSP
L
T
E
DG
KI
R
A
R
I
V
G
GY
Q
N
N
D
S
WL
D
RYNS
E
K
A
FF
SG
IVD
A
D
LG
DLTM
L
SAG
----------
-
-
--Y
E
Y
QRI
D
VNS
PT
W
G
--
-
-G
LP
RW
N
T
DG--
--
S
S
NS
Y
D
RARSTAP
D
W
A
YND
KEI
N
KVF
M
T
--------
L
K
Q
R
F
A
DT
W
Q
A
T
L
N
A
T
H
SEV
E
F
D
S
--
KM
MY
V
D
AY
VNKA
D
GMLVG
P
YS
NYGPGFDY
VGGTGWNSGKRKVD
A
LDLFA
D
GSY
E
L
F
GR
Q
-
-
-
-
-
-
-
-
--
-
-
-
H
N
L
M
---------------
F
G
G
S
Y
S
K
QN
N
RYF
S
S
--------------------
W
A
--
---
-
---
-
--
N
IF-
PD
E
IGSFYNFNG
N
FP
Q
TDWSPQSL
A
QDD
T
T
HMKS
LYA
A
T
RV
T
LADP
L
H
L
I
L
G
A
R
YT
N
W
--
R
V
D
T
L
T
Y
------------
---------
-
-
-----
SMEK
N
HT
T
P
Y
AG
LV
F
D
I
N
DN
W
-
S
T
Y
A
SY
T
S
I
FQ
-----
P
---------
-
Q
NDR
---
D
S
S
G
KY
-
L
T
P
I
T
GN
N
YE
L
G
L
K
SDWM
N
S
RL
TT
T
L
A
I
FR
IEQD
N
VAQ
STGTPIPG
S
N
G
E
T
A
Y
KA
V
--
D
GT
V
S
KGVE
F
E
LN
---
GAIT
D
N
WQ
L
T
F
G
A
T
RYI
AE
DNEG
N
AV
N
P
N
--
--
--------
L
P
R
T
TVK
MF
T
S
Y
RLP
V
M
P
--
E
LTVG
G
G
V
NW
Q
N
---
R
VYTDT
V
-
T
P
Y
GT
FR
A
EQ
GSY
A
L
VD
L
FT
RY
Q
V
T
K
----
N
F
S
L
Q
G
NVNNLFD
KT
Y
DTN
VEG
S
I
V
-------
---Y
GAPR
N
F
SI
T
G
T
YQ
F
fig|585397.9.peg.1252
Escherichia coli ED1a (21-729/729)
L
AG
CIA
L
ALLP
SA
A
F
AA
P
VT-
--
E
E
T
V
I
VE
G
S
A
---
T
AP
D
D
GE
----
NDYNVTSTSA
GTK
MQM
T
QR
D
I
PQS
V
T
I
VS
Q
Q
R
M
E
DQQ
LQ
T
L
G
E
VM
E
NT
L
G
I
S
---
-
-
-K
S
Q
A
D
S
D
R
A
LY
Y
S
RGF
-
----
Q
ID
N
Y
M
V
DGI
PT
YFESRWN
L
G
D
----
A
LS
D
MALF
ERVEV
V
RG
A
T
G
LM
T
G
T
G
N
P
S
A
A
INMV
R
K
H
A
T
S
REF
K
G
DVSA
EY
GS
WNKE
R
YVA
D
LQSP
L
T
E
DG
KI
R
A
R
I
V
G
GY
Q
N
N
D
S
WL
D
RYNS
E
K
A
FF
SG
IVD
A
D
LG
DLTM
L
SAG
----------
-
-
--Y
E
Y
QRI
D
VNS
PT
W
G
--
-
-G
LP
RW
N
T
DG--
--
S
S
NS
Y
D
RARSTAP
D
W
A
YND
KEI
N
KVF
M
T
--------
L
K
Q
R
F
A
DT
W
Q
A
T
L
N
A
T
H
SEV
E
F
D
S
--
KM
MY
V
D
AY
VNKA
D
GMLVG
P
YS
NYGPGFDY
VGGTGWNSGKRKVD
A
LDLFA
D
GSY
E
L
F
GR
Q
-
-
-
-
-
-
-
-
--
-
-
-
H
N
L
M
---------------
F
G
G
S
Y
S
K
QN
N
RYF
S
S
--------------------
W
A
--
---
-
---
-
--
N
IF-
PD
E
IGSFYNFNG
N
FP
Q
TDWSPQSL
A
QDD
T
T
HMKS
LYA
A
T
RV
T
LADP
L
H
L
I
L
G
A
R
YT
N
W
--
R
V
D
T
L
T
Y
------------
---------
-
-
-----
SMEK
N
HT
T
P
Y
AG
LV
F
D
I
N
DN
W
-
S
T
Y
A
SY
T
S
I
FQ
-----
P
---------
-
Q
NDR
---
D
S
S
G
KY
-
L
T
P
I
T
GN
N
YE
L
G
L
K
SDWM
N
S
RL
TT
T
L
A
I
FR
IEQD
N
VAQ
STGTPIPG
S
N
G
E
T
A
Y
KA
V
--
D
GT
V
S
KGVE
F
E
LN
---
GAIT
D
N
WQ
L
T
F
G
A
T
RYI
AE
DNEG
N
AV
N
P
N
--
--
--------
L
P
R
T
TVK
MF
T
S
Y
RLP
V
M
P
--
E
LTVG
G
G
V
NW
Q
N
---
R
VYTDT
V
-
T
P
Y
GT
FR
A
EQ
GSY
A
L
VD
L
FT
RY
Q
V
T
K
----
N
F
S
L
Q
G
NVNNLFD
KT
Y
DTN
VEG
S
I
V
-------
---Y
GAPR
N
F
SI
T
G
T
YQ
F
fig|585057.4.peg.2140
Escherichia coli IAI39 (21-729/729)
L
AG
CIA
L
ALLP
SA
A
F
AA
P
AT-
--
E
E
T
V
I
VE
G
S
A
---
T
AP
D
N
GE
----
NDYNVTSTSA
GTK
MQM
T
QR
D
I
PQS
V
T
I
VS
Q
Q
R
M
E
DQQ
LQ
T
L
G
E
VM
E
NT
L
G
I
S
---
-
-
-K
S
Q
A
D
S
D
R
A
LY
Y
S
RGF
-
----
Q
ID
N
Y
M
V
DGI
PT
YFESRWN
L
G
D
----
A
LS
D
MALF
ERVEV
V
RG
A
T
G
LM
T
G
T
G
N
P
S
A
A
INM
IR
K
H
A
T
S
REF
K
G
DVSA
EY
GS
WNKE
R
YVA
D
LQSP
L
T
E
DG
KI
R
A
R
I
V
G
GY
Q
N
N
D
S
WL
D
RYNS
E
KT
FF
SG
IVD
A
D
LG
DLTT
L
SAG
----------
-
-
--Y
E
Y
QRI
D
VNS
PT
R
G
--
-
-G
LP
RW
N
T
DG--
--
S
S
NS
Y
D
RARSTAP
D
W
A
YND
KEI
N
KVF
M
T
--------
L
K
Q
R
F
A
DT
W
Q
A
T
L
N
A
T
H
SEV
E
F
D
S
--
KM
MY
V
D
AY
VNKA
D
GMLVG
P
YS
NYGPGFDY
VGGTGWNSGKRKVD
A
LDLFA
D
GSY
E
L
F
GR
Q
-
-
-
-
-
-
-
-
--
-
-
-
H
N
L
M
---------------
F
G
G
S
Y
S
K
QN
N
RYI
S
S
--------------------
W
A
--
---
-
---
-
--
N
IF-
PD
E
IGSFYNFNG
N
FP
Q
TDWSPQSL
A
QDD
T
T
HMKS
LYA
A
T
RV
T
LADP
L
H
L
I
L
G
A
R
YT
N
W
--
R
V
D
T
L
T
Y
------------
---------
-
-
-----
SMEK
N
HT
T
P
Y
AG
LV
F
D
I
N
DN
W
-
S
T
Y
A
SY
T
S
I
FQ
-----
P
---------
-
Q
NDR
---
D
S
S
G
KY
-
L
AP
I
T
GN
N
YE
L
G
L
K
SDWM
N
S
RL
TT
T
L
A
I
FR
IEQD
N
VAQ
STGTPIPG
S
N
G
E
T
A
Y
KA
V
--
D
GT
V
S
KGVE
F
E
LN
---
GAIT
D
N
W
X
L
T
F
G
A
T
RYI
AE
DNEG
N
AV
N
P
N
--
--
--------
L
P
R
T
TVK
MF
T
S
Y
RLP
V
M
P
--
E
LTVG
G
G
V
NW
Q
N
---
R
VYTDT
V
-
T
P
Y
GT
FR
A
EQ
GSY
A
L
VD
L
FT
RY
Q
V
T
K
----
N
F
S
L
Q
G
NVNNLFD
KT
Y
DTN
VEG
S
I
V
-------
---Y
GAPR
N
F
SI
T
G
T
YQ
F
fig|550672.3.peg.1380
Escherichia coli B088 (14-729/729)
ASTKP
S
L
L
AG
CIA
L
ALLP
SA
A
F
AA
P
AT-
--
E
E
T
V
I
VE
G
S
A
---
T
AP
D
D
GE
----
NDYSVTSTSA
GTK
MQM
T
QR
D
I
PQS
V
T
I
VS
Q
Q
R
M
E
DQQ
LQ
T
L
G
E
VM
E
NT
L
G
I
S
---
-
-
-K
S
Q
A
D
S
D
R
A
LY
Y
S
RGF
-
----
Q
ID
N
Y
M
V
DGI
PT
YFESRWN
L
G
D
----
A
LS
D
MALF
ERVEV
V
RG
A
T
G
LM
T
G
T
G
N
P
S
A
A
INMV
R
K
H
A
T
S
REF
K
G
DVSA
EY
GS
WNKE
R
YVA
D
LQSP
L
T
E
DG
KI
R
A
R
I
V
G
GY
Q
N
N
D
S
WL
D
RYNS
E
KT
FF
SG
IVD
A
D
LG
DLTT
L
SAG
----------
-
-
--Y
E
Y
QRI
D
VNS
PT
W
G
--
-
-G
LP
RW
N
T
DG--
--
S
S
NS
Y
D
RARSTAP
D
W
A
YND
KEI
N
KVF
M
T
--------
L
K
Q
R
F
A
DT
W
Q
A
T
L
N
A
T
H
SEV
E
F
D
S
--
KM
MY
V
D
AY
VNKA
D
GMLVG
P
YS
NYGPGFDY
VGGTGWNSGKRKVD
A
LDLFA
D
GIY
E
L
F
GR
Q
-
-
-
-
-
-
-
-
--
-
-
-
H
N
L
M
---------------
F
G
G
S
Y
S
K
QN
N
RYF
S
S
--------------------
W
A
--
---
-
---
-
--
N
IF-
PD
E
IGSFYNFNG
N
FP
Q
TDWSPQSL
A
QDD
T
T
HMKS
LYA
A
T
RV
T
LADP
L
H
L
I
L
G
A
R
YT
N
W
--
R
V
D
T
L
T
Y
------------
---------
-
-
-----
SMEK
N
HT
T
P
Y
AG
LV
F
D
I
N
DN
W
-
S
T
Y
A
SY
T
S
I
FQ
-----
P
---------
-
Q
NDR
---
D
S
S
G
KY
-
L
AP
I
T
GN
N
YE
L
G
L
K
SDWM
N
S
RL
TT
T
L
A
I
FR
IEQD
N
VAQ
STGTPIPG
S
N
G
E
T
A
Y
KA
V
--
D
GT
V
S
KGVE
F
E
LN
---
GAIT
D
N
WQ
L
T
F
G
A
T
RYI
AE
DNEG
N
AV
N
P
N
--
--
--------
L
P
R
T
TVK
MF
T
S
Y
RLP
V
M
P
--
E
LTVG
G
G
V
NW
Q
N
---
R
VYTDT
V
-
T
P
Y
GT
FR
A
EQ
GSY
A
L
VD
L
FT
RY
Q
V
T
K
----
N
F
S
L
Q
G
NVNNLFD
KT
Y
DTN
VEG
S
I
V
-------
---Y
G
T
PR
N
F
SI
T
G
T
YQ
F
fig|431946.3.peg.1050
Escherichia coli SE15 (21-729/729)
L
AG
CIA
L
ALLP
SA
A
F
AA
P
AT-
--
E
E
T
V
I
VE
G
S
A
---
T
AP
D
D
GE
----
NDYNVTSTSA
GTK
MQM
T
QR
D
I
PQS
V
T
I
VS
Q
Q
R
M
E
DQQ
LQ
T
L
G
E
VM
E
NT
L
G
I
S
---
-
-
-K
S
Q
A
D
S
D
R
A
LY
Y
S
RGF
-
----
Q
ID
N
Y
M
V
DGI
PT
YFESRWN
L
G
D
----
A
LS
D
MALF
ERVEV
V
RG
A
T
G
LM
T
G
T
G
N
P
S
A
A
INMV
R
K
H
A
T
S
REF
K
G
DVSA
EY
GS
WNKE
R
YVA
D
LQSP
L
T
E
DG
KI
R
A
R
I
V
G
GY
Q
N
N
D
S
WL
D
RYNS
E
KT
FF
SG
IVD
A
D
LG
DLTM
L
SAG
----------
-
-
--Y
E
Y
QRI
D
VNS
PT
W
G
--
-
-G
LP
RW
N
T
DG--
--
S
S
NS
Y
D
RARSTAP
D
W
A
YND
KEI
N
KVF
M
T
--------
L
K
Q
R
F
A
DT
W
Q
A
T
L
N
A
T
H
SEV
E
F
D
S
--
KM
MY
V
D
AY
VNKA
D
GMLVG
P
YS
NYGPGFDY
VGGTGWNSGKRKVD
A
LDLFA
D
GSY
E
L
F
GR
Q
-
-
-
-
-
-
-
-
--
-
-
-
H
N
L
M
---------------
F
G
G
S
Y
S
K
QN
N
RYF
S
S
--------------------
W
A
--
---
-
---
-
--
N
IF-
PD
E
IGSFYNFNG
N
FP
Q
TDRSPQSL
A
QDD
T
T
HMKS
LYA
A
T
RV
T
LADP
L
H
L
I
L
G
A
R
YT
K
W
--
R
V
D
T
L
T
Y
------------
---------
-
-
-----
SMEK
N
HT
T
P
Y
AG
LV
F
D
I
N
DN
W
-
S
T
Y
A
SY
T
S
I
FQ
-----
P
---------
-
Q
NDR
---
D
S
S
G
KY
-
L
AP
I
T
GN
N
YE
L
G
L
K
SDWM
N
S
RL
TT
T
L
A
I
FR
IEQD
N
VAQ
STGTPIPG
S
N
G
E
T
A
Y
KA
V
--
D
GT
V
S
KGVE
F
E
LN
---
GAIT
D
N
WQ
L
T
F
G
A
T
RYI
AE
DNEG
N
AV
N
P
N
--
--
--------
L
P
R
T
TVK
MF
T
S
Y
RLP
V
M
P
--
E
LTVG
G
G
V
NW
Q
N
---
R
VYTDT
V
-
T
P
Y
GT
FR
A
EQ
GSY
A
L
VD
L
FT
RY
Q
V
T
K
----
N
F
S
L
Q
G
NVNNLFD
KT
Y
DTN
VEG
S
I
V
-------
---Y
GAPR
N
L
SI
T
G
M
YQ
F
fig|362663.8.peg.1114
Escherichia coli 536 (21-729/729)
L
AG
CIA
L
ALLP
SA
A
F
AA
P
AT-
--
E
E
T
V
I
VE
G
S
A
---
T
AP
D
D
GE
----
NDYNVTSTSA
GTK
MQM
T
QR
D
I
PQS
V
T
I
VS
Q
Q
R
M
E
DQQ
LQ
T
L
G
E
VM
E
NT
L
G
I
S
---
-
-
-K
S
Q
A
D
S
D
R
A
LY
Y
S
RGF
-
----
Q
ID
N
Y
M
V
DGI
PT
YFESRWN
L
G
D
----
A
LS
D
MALF
ERVEV
V
RG
A
T
G
LM
T
G
T
G
N
P
S
A
A
INMV
R
K
H
A
T
S
REF
K
G
DVSA
EY
GS
WNKE
R
YVA
D
LQSP
L
T
E
DG
KI
R
A
R
I
V
G
GY
Q
N
N
D
S
WL
D
RYNS
E
KT
FF
SG
IVD
A
D
LG
DLTM
L
SAG
----------
-
-
--Y
E
Y
QRI
D
VNS
PT
W
G
--
-
-G
LP
RW
N
T
DG--
--
S
S
NS
Y
D
RARSTAP
D
W
A
YND
KEI
N
KVF
M
T
--------
L
K
Q
R
F
A
DT
W
Q
A
T
L
N
A
T
H
SEV
E
F
D
S
--
KM
MY
V
D
AY
VNKA
D
GMLVG
P
YS
NYGPGFDY
VGGTGWNSGKRKVD
A
LDLFA
D
GSY
E
L
F
GR
Q
-
-
-
-
-
-
-
-
--
-
-
-
H
N
L
M
---------------
F
G
G
S
Y
S
K
QN
N
RYF
S
S
--------------------
W
A
--
---
-
---
-
--
N
IF-
PD
E
IGSFYNFNG
N
FP
Q
TDWSPQSL
A
QND
T
T
HMKS
LYA
A
T
RV
T
LADP
L
H
L
I
L
G
A
R
YT
N
W
--
R
V
D
T
L
T
Y
------------
---------
-
-
-----
SMEK
N
HT
T
P
Y
AG
LV
F
D
I
N
DN
W
-
S
T
Y
A
SY
T
S
I
FQ
-----
P
---------
-
Q
NDR
---
D
S
S
G
KY
-
L
T
P
I
T
GN
N
YE
L
G
L
K
SDWM
N
S
RL
TT
T
L
A
I
FR
IEQD
N
VAQ
STGTPIPG
S
N
G
E
T
A
Y
KA
V
--
D
GT
V
S
KGVE
F
E
LN
---
GAIT
D
N
WQ
L
T
F
G
A
T
RYI
AE
DNEG
N
AV
N
P
N
--
--
--------
L
P
R
T
TFK
MF
T
S
Y
RLP
V
M
P
--
E
LTVG
G
G
V
NW
Q
N
---
R
VYTDT
V
-
T
P
Y
GT
FR
A
EQ
GSY
A
L
VD
L
FT
RY
Q
V
T
K
----
N
F
S
L
Q
G
NVNNLFD
KT
Y
DTN
VEG
S
I
V
-------
---Y
GAPR
N
F
SI
T
G
T
YQ
F
fig|362663.9.peg.1114
Escherichia coli 536 (21-729/729)
L
AG
CIA
L
ALLP
SA
A
F
AA
P
AT-
--
E
E
T
V
I
VE
G
S
A
---
T
AP
D
D
GE
----
NDYNVTSTSA
GTK
MQM
T
QR
D
I
PQS
V
T
I
VS
Q
Q
R
M
E
DQQ
LQ
T
L
G
E
VM
E
NT
L
G
I
S
---
-
-
-K
S
Q
A
D
S
D
R
A
LY
Y
S
RGF
-
----
Q
ID
N
Y
M
V
DGI
PT
YFESRWN
L
G
D
----
A
LS
D
MALF
ERVEV
V
RG
A
T
G
LM
T
G
T
G
N
P
S
A
A
INMV
R
K
H
A
T
S
REF
K
G
DVSA
EY
GS
WNKE
R
YVA
D
LQSP
L
T
E
DG
KI
R
A
R
I
V
G
GY
Q
N
N
D
S
WL
D
RYNS
E
KT
FF
SG
IVD
A
D
LG
DLTM
L
SAG
----------
-
-
--Y
E
Y
QRI
D
VNS
PT
W
G
--
-
-G
LP
RW
N
T
DG--
--
S
S
NS
Y
D
RARSTAP
D
W
A
YND
KEI
N
KVF
M
T
--------
L
K
Q
R
F
A
DT
W
Q
A
T
L
N
A
T
H
SEV
E
F
D
S
--
KM
MY
V
D
AY
VNKA
D
GMLVG
P
YS
NYGPGFDY
VGGTGWNSGKRKVD
A
LDLFA
D
GSY
E
L
F
GR
Q
-
-
-
-
-
-
-
-
--
-
-
-
H
N
L
M
---------------
F
G
G
S
Y
S
K
QN
N
RYF
S
S
--------------------
W
A
--
---
-
---
-
--
N
IF-
PD
E
IGSFYNFNG
N
FP
Q
TDWSPQSL
A
QND
T
T
HMKS
LYA
A
T
RV
T
LADP
L
H
L
I
L
G
A
R
YT
N
W
--
R
V
D
T
L
T
Y
------------
---------
-
-
-----
SMEK
N
HT
T
P
Y
AG
LV
F
D
I
N
DN
W
-
S
T
Y
A
SY
T
S
I
FQ
-----
P
---------
-
Q
NDR
---
D
S
S
G
KY
-
L
T
P
I
T
GN
N
YE
L
G
L
K
SDWM
N
S
RL
TT
T
L
A
I
FR
IEQD
N
VAQ
STGTPIPG
S
N
G
E
T
A
Y
KA
V
--
D
GT
V
S
KGVE
F
E
LN
---
GAIT
D
N
WQ
L
T
F
G
A
T
RYI
AE
DNEG
N
AV
N
P
N
--
--
--------
L
P
R
T
TFK
MF
T
S
Y
RLP
V
M
P
--
E
LTVG
G
G
V
NW
Q
N
---
R
VYTDT
V
-
T
P
Y
GT
FR
A
EQ
GSY
A
L
VD
L
FT
RY
Q
V
T
K
----
N
F
S
L
Q
G
NVNNLFD
KT
Y
DTN
VEG
S
I
V
-------
---Y
GAPR
N
F
SI
T
G
T
YQ
F
fig|1040638.4.peg.4427
Escherichia coli O104:H4 str. LB226692 (21-729/729)
L
AG
CIA
L
ALLP
SA
A
F
AA
P
AT-
--
E
E
T
V
I
VE
G
S
A
---
T
AP
D
D
GE
----
NDYSVTSTSA
GTK
MQM
T
QR
D
I
PQS
V
T
I
VS
Q
Q
R
M
E
DQQ
LQ
T
L
G
E
VM
E
NT
L
G
I
S
---
-
-
-K
S
Q
A
D
S
D
R
A
LY
Y
S
RGF
-
----
Q
ID
N
Y
M
V
DGI
PT
YFESRWN
L
G
D
----
A
LS
D
MALF
ERVEV
V
RG
A
T
G
LM
T
G
T
G
N
P
S
A
A
INMV
R
K
H
A
T
S
REF
K
G
DVSA
EY
GS
WNKE
R
YVA
D
LQSP
L
T
E
DG
KI
R
A
R
I
V
G
GY
Q
N
N
D
S
WL
D
RYNS
E
KT
FF
SG
IVD
A
D
LG
DLTT
L
SAG
----------
-
-
--Y
E
Y
QRI
D
VNS
PT
W
G
--
-
-G
LP
RW
N
T
DG--
--
S
S
NS
Y
D
RARSTAP
D
W
A
YND
KEI
N
KVF
M
T
--------
L
K
Q
R
F
A
DT
W
Q
A
T
L
N
A
T
H
SEV
E
F
D
S
--
KM
MY
V
D
AY
VNKA
D
GMLVG
P
YS
NYGPGFDY
VGGTGWNSGKRKVD
A
LDLFA
D
GIY
E
L
F
GR
Q
-
-
-
-
-
-
-
-
--
-
-
-
H
N
L
M
---------------
F
G
G
S
Y
S
K
QN
N
RYF
S
S
--------------------
W
A
--
---
-
---
-
--
N
IF-
PD
E
IGSFYNFNG
N
FP
Q
TDWSPQSL
A
QDD
T
T
HMKS
LYA
A
T
RV
T
LADP
L
H
L
I
L
G
A
R
YT
N
W
--
R
V
D
T
L
T
Y
------------
---------
-
-
-----
SMEK
N
HT
T
P
Y
AG
LV
F
D
I
N
DN
W
-
S
T
Y
A
SY
T
S
I
FQ
-----
P
---------
-
Q
NDR
---
D
S
S
G
KY
-
L
AP
I
T
GN
N
YE
L
G
L
K
SDWM
N
S
RL
TT
T
L
A
I
FR
IEQD
N
VAQ
STGTPIPG
S
N
G
E
T
A
Y
KA
V
--
D
GT
V
S
KGVE
F
E
LN
---
GAIT
D
N
WQ
L
T
F
G
A
T
RYI
AE
DNEG
N
AV
N
P
N
--
--
--------
L
P
R
T
TVK
MF
T
S
Y
RLP
V
M
P
--
E
LTVG
G
G
V
NW
Q
N
---
R
VYTDT
V
-
T
P
Y
GT
FR
A
EQ
GSY
A
L
VD
L
FT
RY
Q
V
T
K
----
N
F
S
L
Q
G
NVNNLFD
KT
Y
DTN
VEG
S
I
V
-------
---Y
G
T
PR
N
F
SI
T
G
T
YQ
F
fig|6666666.5357.peg.1304
Escherichia coli TY-2482 (21-729/729)
L
AG
CIA
L
ALLP
SA
A
F
AA
P
AT-
--
E
E
T
V
I
VE
G
S
A
---
T
AP
D
D
GE
----
NDYSVTSTSA
GTK
MQM
T
QR
D
I
PQS
V
T
I
VS
Q
Q
R
M
E
DQQ
LQ
T
L
G
E
VM
E
NT
L
G
I
S
---
-
-
-K
S
Q
A
D
S
D
R
A
LY
Y
S
RGF
-
----
Q
ID
N
Y
M
V
DGI
PT
YFESRWN
L
G
D
----
A
LS
D
MALF
ERVEV
V
RG
A
T
G
LM
T
G
T
G
N
P
S
A
A
INMV
R
K
H
A
T
S
REF
K
G
DVSA
EY
GS
WNKE
R
YVA
D
LQSP
L
T
E
DG
KI
R
A
R
I
V
G
GY
Q
N
N
D
S
WL
D
RYNS
E
KT
FF
SG
IVD
A
D
LG
DLTT
L
SAG
----------
-
-
--Y
E
Y
QRI
D
VNS
PT
W
G
--
-
-G
LP
RW
N
T
DG--
--
S
S
NS
Y
D
RARSTAP
D
W
A
YND
KEI
N
KVF
M
T
--------
L
K
Q
R
F
A
DT
W
Q
A
T
L
N
A
T
H
SEV
E
F
D
S
--
KM
MY
V
D
AY
VNKA
D
GMLVG
P
YS
NYGPGFDY
VGGTGWNSGKRKVD
A
LDLFA
D
GIY
E
L
F
GR
Q
-
-
-
-
-
-
-
-
--
-
-
-
H
N
L
M
---------------
F
G
G
S
Y
S
K
QN
N
RYF
S
S
--------------------
W
A
--
---
-
---
-
--
N
IF-
PD
E
IGSFYNFNG
N
FP
Q
TDWSPQSL
A
QDD
T
T
HMKS
LYA
A
T
RV
T
LADP
L
H
L
I
L
G
A
R
YT
N
W
--
R
V
D
T
L
T
Y
------------
---------
-
-
-----
SMEK
N
HT
T
P
Y
AG
LV
F
D
I
N
DN
W
-
S
T
Y
A
SY
T
S
I
FQ
-----
P
---------
-
Q
NDR
---
D
S
S
G
KY
-
L
AP
I
T
GN
N
YE
L
G
L
K
SDWM
N
S
RL
TT
T
L
A
I
FR
IEQD
N
VAQ
STGTPIPG
S
N
G
E
T
A
Y
KA
V
--
D
GT
V
S
KGVE
F
E
LN
---
GAIT
D
N
WQ
L
T
F
G
A
T
RYI
AE
DNEG
N
AV
N
P
N
--
--
--------
L
P
R
T
TVK
MF
T
S
Y
RLP
V
M
P
--
E
LTVG
G
G
V
NW
Q
N
---
R
VYTDT
V
-
T
P
Y
GT
FR
A
EQ
GSY
A
L
VD
L
FT
RY
Q
V
T
K
----
N
F
S
L
Q
G
NVNNLFD
KT
Y
DTN
VEG
S
I
V
-------
---Y
G
T
PR
N
F
SI
T
G
T
YQ
F
fig|585055.6.peg.1245
Escherichia coli 55989 (21-729/729)
L
AG
CIA
L
ALLP
SA
A
F
AA
P
AT-
--
E
E
T
V
I
VE
G
S
A
---
T
AP
D
D
GE
----
NDYSVTSTSA
GTK
MQM
T
QR
D
I
PQS
V
T
I
VS
Q
Q
R
M
E
DQQ
LQ
T
L
G
E
VM
E
NT
L
G
I
S
---
-
-
-K
S
Q
A
D
S
D
R
A
LY
Y
S
RGF
-
----
Q
ID
N
Y
M
V
DGI
PT
YFESRWN
L
G
D
----
A
LS
D
MALF
ERVEV
V
RG
A
T
G
LM
T
G
T
G
N
P
S
A
A
INMV
R
K
H
A
T
S
REF
K
G
DVSA
EY
GS
WNKE
R
YVA
D
LQSP
L
T
E
DG
KI
R
A
R
I
V
G
GY
Q
N
N
D
S
WL
D
RYNS
E
KT
FF
SG
IVD
A
D
LG
DLTT
L
SAG
----------
-
-
--Y
E
Y
QRI
D
VNS
PT
W
G
--
-
-G
LP
RW
N
T
DG--
--
S
S
NS
Y
D
RARSTAP
D
W
A
YND
KEI
N
KVF
M
T
--------
L
K
Q
R
F
A
DT
W
Q
A
T
L
N
A
T
H
SEV
E
F
D
S
--
KM
MY
V
D
AY
VNKA
D
GMLVG
P
YS
NYGPGFDY
VGGTGWNSGKRKVD
A
LDLFA
D
GIY
E
L
F
GR
Q
-
-
-
-
-
-
-
-
--
-
-
-
H
N
L
M
---------------
F
G
G
S
Y
S
K
QN
N
RYF
S
S
--------------------
W
A
--
---
-
---
-
--
N
IF-
PD
E
IGSFYNFNG
N
FP
Q
TDWSPQSL
A
QDD
T
T
HMKS
LYA
A
T
RV
T
LADP
L
H
L
I
L
G
A
R
YT
N
W
--
R
V
D
T
L
T
Y
------------
---------
-
-
-----
SMEK
N
HT
T
P
Y
AG
LV
F
D
I
N
DN
W
-
S
T
Y
A
SY
T
S
I
FQ
-----
P
---------
-
Q
NDR
---
D
S
S
G
KY
-
L
AP
I
T
GN
N
YE
L
G
L
K
SDWM
N
S
RL
TT
T
L
A
I
FR
IEQD
N
VAQ
STGTPIPG
S
N
G
E
T
A
Y
KA
V
--
D
GT
V
S
KGVE
F
E
LN
---
GAIT
D
N
WQ
L
T
F
G
A
T
RYI
AE
DNEG
N
AV
N
P
N
--
--
--------
L
P
R
T
TVK
MF
T
S
Y
RLP
V
M
P
--
E
LTVG
G
G
V
NW
Q
N
---
R
VYTDT
V
-
T
P
Y
GT
FR
A
EQ
GSY
A
L
VD
L
FT
RY
Q
V
T
K
----
N
F
S
L
Q
G
NVNNLFD
KT
Y
DTN
VEG
S
I
V
-------
---Y
G
T
PR
N
F
SI
T
G
T
YQ
F
fig|585055.8.peg.1244
Escherichia coli 55989 (21-729/729)
L
AG
CIA
L
ALLP
SA
A
F
AA
P
AT-
--
E
E
T
V
I
VE
G
S
A
---
T
AP
D
D
GE
----
NDYSVTSTSA
GTK
MQM
T
QR
D
I
PQS
V
T
I
VS
Q
Q
R
M
E
DQQ
LQ
T
L
G
E
VM
E
NT
L
G
I
S
---
-
-
-K
S
Q
A
D
S
D
R
A
LY
Y
S
RGF
-
----
Q
ID
N
Y
M
V
DGI
PT
YFESRWN
L
G
D
----
A
LS
D
MALF
ERVEV
V
RG
A
T
G
LM
T
G
T
G
N
P
S
A
A
INMV
R
K
H
A
T
S
REF
K
G
DVSA
EY
GS
WNKE
R
YVA
D
LQSP
L
T
E
DG
KI
R
A
R
I
V
G
GY
Q
N
N
D
S
WL
D
RYNS
E
KT
FF
SG
IVD
A
D
LG
DLTT
L
SAG
----------
-
-
--Y
E
Y
QRI
D
VNS
PT
W
G
--
-
-G
LP
RW
N
T
DG--
--
S
S
NS
Y
D
RARSTAP
D
W
A
YND
KEI
N
KVF
M
T
--------
L
K
Q
R
F
A
DT
W
Q
A
T
L
N
A
T
H
SEV
E
F
D
S
--
KM
MY
V
D
AY
VNKA
D
GMLVG
P
YS
NYGPGFDY
VGGTGWNSGKRKVD
A
LDLFA
D
GIY
E
L
F
GR
Q
-
-
-
-
-
-
-
-
--
-
-
-
H
N
L
M
---------------
F
G
G
S
Y
S
K
QN
N
RYF
S
S
--------------------
W
A
--
---
-
---
-
--
N
IF-
PD
E
IGSFYNFNG
N
FP
Q
TDWSPQSL
A
QDD
T
T
HMKS
LYA
A
T
RV
T
LADP
L
H
L
I
L
G
A
R
YT
N
W
--
R
V
D
T
L
T
Y
------------
---------
-
-
-----
SMEK
N
HT
T
P
Y
AG
LV
F
D
I
N
DN
W
-
S
T
Y
A
SY
T
S
I
FQ
-----
P
---------
-
Q
NDR
---
D
S
S
G
KY
-
L
AP
I
T
GN
N
YE
L
G
L
K
SDWM
N
S
RL
TT
T
L
A
I
FR
IEQD
N
VAQ
STGTPIPG
S
N
G
E
T
A
Y
KA
V
--
D
GT
V
S
KGVE
F
E
LN
---
GAIT
D
N
WQ
L
T
F
G
A
T
RYI
AE
DNEG
N
AV
N
P
N
--
--
--------
L
P
R
T
TVK
MF
T
S
Y
RLP
V
M
P
--
E
LTVG
G
G
V
NW
Q
N
---
R
VYTDT
V
-
T
P
Y
GT
FR
A
EQ
GSY
A
L
VD
L
FT
RY
Q
V
T
K
----
N
F
S
L
Q
G
NVNNLFD
KT
Y
DTN
VEG
S
I
V
-------
---Y
G
T
PR
N
F
SI
T
G
T
YQ
F
fig|749544.3.peg.1992
Escherichia coli MS 175-1 (21-729/729)
L
AG
CIA
L
ALLP
SA
A
F
AA
P
AT-
--
E
E
T
V
I
VE
G
S
A
---
T
AP
D
D
GE
----
NDYSVTSTSA
GTK
MQM
T
QR
D
I
PQS
V
T
I
VS
Q
Q
R
M
E
DQQ
LQ
T
L
G
E
VM
E
NT
L
G
I
S
---
-
-
-K
S
Q
A
D
S
D
R
A
LY
Y
S
RGF
-
----
Q
ID
N
Y
M
V
DGI
PT
YFESRWN
L
G
D
----
A
LS
D
MALF
ERVEV
V
RG
A
T
G
LM
T
G
T
G
N
P
S
A
A
INMV
R
K
H
A
T
S
REF
K
G
DVSA
EY
GS
WNKE
R
YVA
D
LQSP
L
T
E
DG
KI
R
A
R
I
V
G
GY
Q
N
N
D
S
WL
D
RYNS
E
KT
FF
SG
IVD
A
D
LG
DLTT
L
SAG
----------
-
-
--Y
E
Y
QRI
D
VNS
PT
W
G
--
-
-G
LP
RW
N
T
DG--
--
S
S
NS
Y
D
RARSTAP
D
W
A
YND
KEI
N
KVF
M
T
--------
L
K
Q
Q
F
A
D
I
W
Q
A
T
L
N
A
T
H
SEV
E
F
D
S
--
KM
MY
V
D
AY
VNKA
D
GMLVG
P
YS
NYGPGFDY
VGGTGWNSGKRKVD
A
LDLFA
D
GSY
E
L
F
GR
Q
-
-
-
-
-
-
-
-
--
-
-
-
H
N
L
M
---------------
F
G
G
S
Y
S
K
QN
N
RYF
S
S
--------------------
W
A
--
---
-
---
-
--
N
IF-
PD
E
IGSFYNFNG
N
FP
Q
TDWSPQSL
A
QDD
T
T
HMKS
LYA
A
T
RV
T
LADP
L
H
L
I
L
G
A
R
YT
N
W
--
R
V
D
T
L
T
Y
------------
---------
-
-
-----
SMEK
N
HT
T
P
Y
AG
LV
F
D
I
N
DN
W
-
S
T
Y
A
SY
T
S
I
FQ
-----
P
---------
-
Q
NDR
---
D
S
S
G
KY
-
L
AP
I
T
GN
N
YE
L
G
L
K
SDWM
N
S
RL
TT
T
L
A
I
FR
IEQD
N
VAQ
STGTPIPG
S
N
G
E
T
A
Y
KA
V
--
D
GT
V
S
KGVE
F
E
LN
---
GAIT
D
N
WQ
L
T
F
G
A
T
RYI
AE
DNEG
N
AV
N
P
N
--
--
--------
L
P
R
T
TVK
MF
T
S
Y
RLP
V
M
P
--
E
LTVG
G
G
V
NW
Q
N
---
R
VYTDT
V
-
T
P
Y
GT
FR
A
EQ
GSY
A
L
VD
L
FT
RY
Q
V
T
K
----
N
F
S
L
Q
G
NVNNLFD
KT
Y
DTN
VEG
S
I
V
-------
---Y
G
T
PR
N
F
SI
T
G
T
YQ
F
fig|685038.3.peg.1070
Escherichia coli O83:H1 str. NRG 857C (21-729/729)
L
AG
CIA
L
ALLP
SA
A
F
AA
P
VT-
--
E
E
T
V
I
VE
G
S
A
---
T
AP
D
D
GE
----
NDYNVTSTSA
GTK
MQM
T
QR
D
I
PQS
V
T
I
VS
Q
Q
R
M
E
DQQ
LQ
T
L
G
E
VM
E
NT
L
G
I
S
---
-
-
-K
S
Q
A
D
S
D
R
A
LY
Y
S
RGF
-
----
Q
ID
N
Y
M
V
DGI
PT
YFESRWN
L
G
D
----
A
LS
D
MALF
ERVEV
V
RG
A
T
G
LM
T
G
T
G
N
P
S
A
A
INMV
R
K
H
A
T
S
REF
K
G
DVSA
EY
GS
WNKE
R
YVA
D
LQSP
L
T
E
DG
KI
R
A
R
I
V
G
GY
Q
N
N
D
S
WL
D
RYNS
E
KT
FF
SG
IVD
A
D
LG
DLTM
L
SAG
----------
-
-
--Y
E
Y
QRI
D
VNS
PT
W
G
--
-
-G
LP
RW
N
T
DG--
--
S
S
NS
Y
D
RARSTAP
D
W
A
YND
KEI
N
KVF
M
T
--------
L
K
Q
R
F
A
DT
W
Q
A
T
L
N
A
T
H
SEV
E
F
D
S
--
KM
MY
V
D
AY
VNKA
D
GMLVG
P
YS
NYGPGFDY
VGGTGWNSGKRKVD
A
LDLFA
D
GSY
E
L
F
GR
Q
-
-
-
-
-
-
-
-
--
-
-
-
H
N
L
M
---------------
F
G
G
S
Y
S
K
QN
N
RYF
S
S
--------------------
W
A
--
---
-
---
-
--
N
IF-
PD
E
IGSFYNFNG
N
FP
Q
TDWSPQSL
A
QND
T
T
HMKS
LYA
A
T
RV
T
LADP
L
H
L
I
L
G
A
R
YT
N
W
--
R
V
D
T
L
T
Y
------------
---------
-
-
-----
SMEK
N
HT
T
P
Y
AG
LV
F
D
I
N
DN
W
-
S
T
Y
A
SY
T
S
I
FQ
-----
P
---------
-
Q
NDR
---
D
S
S
G
KY
-
L
T
P
I
T
GN
N
YE
L
G
L
K
SDWM
N
S
RL
TT
T
L
A
I
FR
IEQD
N
VAQ
STGTPIPG
S
N
G
E
T
A
Y
KA
V
--
D
GT
V
S
KGVE
F
E
LN
---
GAIT
D
N
WQ
L
T
F
G
A
T
RYI
AE
DNEG
N
AV
N
P
N
--
--
--------
L
P
R
T
TVK
MF
T
S
Y
RLP
V
M
P
--
E
LTVG
G
G
V
NW
Q
N
---
R
VYTDT
V
-
T
P
Y
GT
FR
A
EQ
GSY
A
L
VD
L
FT
RY
Q
V
T
K
----
N
F
S
L
Q
G
NVNNLFD
KT
Y
DTN
VEG
S
I
V
-------
---Y
GAPR
N
F
SI
T
G
T
YQ
F
fig|525281.3.peg.374
Escherichia coli 83972 (21-729/729)
L
AG
CIA
L
ALLP
SA
A
F
AA
P
VT-
--
E
E
T
V
I
VE
G
S
A
---
T
AP
D
D
GE
----
NDYNVTSTSA
GTK
MQM
T
QR
D
I
PQS
V
T
I
VS
Q
Q
R
M
E
DQQ
LQ
T
L
G
E
VM
E
NT
L
G
I
S
---
-
-
-K
S
Q
A
D
S
D
R
A
LY
Y
S
RGF
-
----
Q
ID
N
Y
M
V
DGI
PT
YFESRWN
L
G
D
----
A
LS
D
MALF
ERVEV
V
RG
A
T
G
LM
T
G
T
G
N
P
S
A
A
INMV
R
K
H
A
T
S
REF
K
G
DVSA
EY
GS
WNKE
R
YVA
D
LQSP
L
T
E
DG
KI
R
A
R
I
V
G
GY
Q
N
N
D
S
WL
D
RYNS
E
KT
FF
SG
IVD
A
D
LG
DLTM
L
SAG
----------
-
-
--Y
E
Y
QRI
D
VNS
PT
W
G
--
-
-G
LP
RW
N
T
DG--
--
S
S
NS
Y
D
RARSTAP
D
W
A
YND
KEI
N
KVF
M
T
--------
L
K
Q
R
F
A
DT
W
Q
A
T
L
N
A
T
H
SEV
E
F
D
S
--
KM
MY
V
D
AY
VNKA
D
GMLVG
P
YS
NYGPGFDY
VGGTGWNSGKRKVD
A
LDLFA
D
GSY
E
L
F
GR
Q
-
-
-
-
-
-
-
-
--
-
-
-
H
N
L
M
---------------
F
G
G
S
Y
S
K
QN
N
RYF
S
S
--------------------
W
A
--
---
-
---
-
--
N
IF-
PD
E
IGSFYNFNG
N
FP
Q
TDWSPQSL
A
QDD
T
T
HMKS
LYA
A
T
RV
T
LADP
L
H
L
I
L
G
A
R
YT
N
W
--
R
V
D
T
L
T
Y
------------
---------
-
-
-----
SMEK
N
HT
T
P
Y
AG
LV
F
D
I
N
DN
W
-
S
T
Y
A
SY
T
S
I
FQ
-----
P
---------
-
Q
NDR
---
D
S
S
G
KY
-
L
T
P
I
T
GN
N
YE
L
G
L
K
SDWM
N
S
RL
TT
T
L
A
I
FR
IEQD
N
VAQ
STGTPIPG
S
N
G
E
T
A
Y
KA
V
--
D
GT
V
S
KGVE
F
E
LN
---
GAIT
D
N
WQ
L
T
F
G
A
T
RYI
AE
DNEG
N
AV
N
P
N
--
--
--------
L
P
R
T
TVK
MF
T
S
Y
RLP
V
M
P
--
E
LTVG
G
G
V
NW
Q
N
---
R
VYTDT
V
-
T
P
Y
GT
FR
A
EQ
GSY
A
L
VD
L
FT
RY
Q
V
T
K
----
N
F
S
L
Q
G
NVNNLFD
KT
Y
DTN
VEG
S
I
V
-------
---Y
GAPR
N
F
SI
T
G
T
YQ
F
fig|655817.3.peg.1389
Escherichia coli ABU 83972 (21-729/729)
L
AG
CIA
L
ALLP
SA
A
F
AA
P
VT-
--
E
E
T
V
I
VE
G
S
A
---
T
AP
D
D
GE
----
NDYNVTSTSA
GTK
MQM
T
QR
D
I
PQS
V
T
I
VS
Q
Q
R
M
E
DQQ
LQ
T
L
G
E
VM
E
NT
L
G
I
S
---
-
-
-K
S
Q
A
D
S
D
R
A
LY
Y
S
RGF
-
----
Q
ID
N
Y
M
V
DGI
PT
YFESRWN
L
G
D
----
A
LS
D
MALF
ERVEV
V
RG
A
T
G
LM
T
G
T
G
N
P
S
A
A
INMV
R
K
H
A
T
S
REF
K
G
DVSA
EY
GS
WNKE
R
YVA
D
LQSP
L
T
E
DG
KI
R
A
R
I
V
G
GY
Q
N
N
D
S
WL
D
RYNS
E
KT
FF
SG
IVD
A
D
LG
DLTM
L
SAG
----------
-
-
--Y
E
Y
QRI
D
VNS
PT
W
G
--
-
-G
LP
RW
N
T
DG--
--
S
S
NS
Y
D
RARSTAP
D
W
A
YND
KEI
N
KVF
M
T
--------
L
K
Q
R
F
A
DT
W
Q
A
T
L
N
A
T
H
SEV
E
F
D
S
--
KM
MY
V
D
AY
VNKA
D
GMLVG
P
YS
NYGPGFDY
VGGTGWNSGKRKVD
A
LDLFA
D
GSY
E
L
F
GR
Q
-
-
-
-
-
-
-
-
--
-
-
-
H
N
L
M
---------------
F
G
G
S
Y
S
K
QN
N
RYF
S
S
--------------------
W
A
--
---
-
---
-
--
N
IF-
PD
E
IGSFYNFNG
N
FP
Q
TDWSPQSL
A
QDD
T
T
HMKS
LYA
A
T
RV
T
LADP
L
H
L
I
L
G
A
R
YT
N
W
--
R
V
D
T
L
T
Y
------------
---------
-
-
-----
SMEK
N
HT
T
P
Y
AG
LV
F
D
I
N
DN
W
-
S
T
Y
A
SY
T
S
I
FQ
-----
P
---------
-
Q
NDR
---
D
S
S
G
KY
-
L
T
P
I
T
GN
N
YE
L
G
L
K
SDWM
N
S
RL
TT
T
L
A
I
FR
IEQD
N
VAQ
STGTPIPG
S
N
G
E
T
A
Y
KA
V
--
D
GT
V
S
KGVE
F
E
LN
---
GAIT
D
N
WQ
L
T
F
G
A
T
RYI
AE
DNEG
N
AV
N
P
N
--
--
--------
L
P
R
T
TVK
MF
T
S
Y
RLP
V
M
P
--
E
LTVG
G
G
V
NW
Q
N
---
R
VYTDT
V
-
T
P
Y
GT
FR
A
EQ
GSY
A
L
VD
L
FT
RY
Q
V
T
K
----
N
F
S
L
Q
G
NVNNLFD
KT
Y
DTN
VEG
S
I
V
-------
---Y
GAPR
N
F
SI
T
G
T
YQ
F
fig|405955.13.peg.1105
Escherichia coli APEC O1 (21-729/729)
L
AG
CIA
L
ALLP
SA
A
F
AA
P
VT-
--
E
E
T
V
I
VE
G
S
A
---
T
AP
D
D
GE
----
NDYNVTSTSA
GTK
MQM
T
QR
D
I
PQS
V
T
I
VS
Q
Q
R
M
E
DQQ
LQ
T
L
G
E
VM
E
NT
L
G
I
S
---
-
-
-K
S
Q
A
D
S
D
R
A
LY
Y
S
RGF
-
----
Q
ID
N
Y
M
V
DGI
PT
YFESRWN
L
G
D
----
A
LS
D
MALF
ERVEV
V
RG
A
T
G
LM
T
G
T
G
N
P
S
A
A
INMV
R
K
H
A
T
S
REF
K
G
DVSA
EY
GS
WNKE
R
YVA
D
LQSP
L
T
E
DG
KI
R
A
R
I
V
G
GY
Q
N
N
D
S
WL
D
RYNS
E
KT
FF
SG
IVD
A
D
LG
DLTM
L
SAG
----------
-
-
--Y
E
Y
QRI
D
VNS
PT
W
G
--
-
-G
LP
RW
N
T
DG--
--
S
S
NS
Y
D
RARSTAP
D
W
A
YND
KEI
N
KVF
M
T
--------
L
K
Q
R
F
A
DT
W
Q
A
T
L
N
A
T
H
SEV
E
F
D
S
--
KM
MY
V
D
AY
VNKA
D
GMLVG
P
YS
NYGPGFDY
VGGTGWNSGKRKVD
A
LDLFA
D
GSY
E
L
F
GR
Q
-
-
-
-
-
-
-
-
--
-
-
-
H
N
L
M
---------------
F
G
G
S
Y
S
K
QN
N
RYF
S
S
--------------------
W
A
--
---
-
---
-
--
N
IF-
PD
E
IGSFYNFNG
N
FP
Q
TDWSPQSL
A
QDD
T
T
HMKS
LYA
A
T
RV
T
LADP
L
H
L
I
L
G
A
R
YT
N
W
--
R
V
D
T
L
T
Y
------------
---------
-
-
-----
SMEK
N
HT
T
P
Y
AG
LV
F
D
I
N
DN
W
-
S
T
Y
A
SY
T
S
I
FQ
-----
P
---------
-
Q
NDR
---
D
S
S
G
KY
-
L
T
P
I
T
GN
N
YE
L
G
L
K
SDWM
N
S
RL
TT
T
L
A
I
FR
IEQD
N
VAQ
STGTPIPG
S
N
G
E
T
A
Y
KA
V
--
D
GT
V
S
KGVE
F
E
LN
---
GAIT
D
N
WQ
L
T
F
G
A
T
RYI
AE
DNEG
N
AV
N
P
N
--
--
--------
L
P
R
T
TVK
MF
T
S
Y
RLP
V
M
P
--
E
LTVG
G
G
V
NW
Q
N
---
R
VYTDT
V
-
T
P
Y
GT
FR
A
EQ
GSY
A
L
VD
L
FT
RY
Q
V
T
K
----
N
F
S
L
Q
G
NVNNLFD
KT
Y
DTN
VEG
S
I
V
-------
---Y
GAPR
N
F
SI
T
G
T
YQ
F
fig|405955.9.peg.929
Escherichia coli APEC O1 (21-729/729)
L
AG
CIA
L
ALLP
SA
A
F
AA
P
VT-
--
E
E
T
V
I
VE
G
S
A
---
T
AP
D
D
GE
----
NDYNVTSTSA
GTK
MQM
T
QR
D
I
PQS
V
T
I
VS
Q
Q
R
M
E
DQQ
LQ
T
L
G
E
VM
E
NT
L
G
I
S
---
-
-
-K
S
Q
A
D
S
D
R
A
LY
Y
S
RGF
-
----
Q
ID
N
Y
M
V
DGI
PT
YFESRWN
L
G
D
----
A
LS
D
MALF
ERVEV
V
RG
A
T
G
LM
T
G
T
G
N
P
S
A
A
INMV
R
K
H
A
T
S
REF
K
G
DVSA
EY
GS
WNKE
R
YVA
D
LQSP
L
T
E
DG
KI
R
A
R
I
V
G
GY
Q
N
N
D
S
WL
D
RYNS
E
KT
FF
SG
IVD
A
D
LG
DLTM
L
SAG
----------
-
-
--Y
E
Y
QRI
D
VNS
PT
W
G
--
-
-G
LP
RW
N
T
DG--
--
S
S
NS
Y
D
RARSTAP
D
W
A
YND
KEI
N
KVF
M
T
--------
L
K
Q
R
F
A
DT
W
Q
A
T
L
N
A
T
H
SEV
E
F
D
S
--
KM
MY
V
D
AY
VNKA
D
GMLVG
P
YS
NYGPGFDY
VGGTGWNSGKRKVD
A
LDLFA
D
GSY
E
L
F
GR
Q
-
-
-
-
-
-
-
-
--
-
-
-
H
N
L
M
---------------
F
G
G
S
Y
S
K
QN
N
RYF
S
S
--------------------
W
A
--
---
-
---
-
--
N
IF-
PD
E
IGSFYNFNG
N
FP
Q
TDWSPQSL
A
QDD
T
T
HMKS
LYA
A
T
RV
T
LADP
L
H
L
I
L
G
A
R
YT
N
W
--
R
V
D
T
L
T
Y
------------
---------
-
-
-----
SMEK
N
HT
T
P
Y
AG
LV
F
D
I
N
DN
W
-
S
T
Y
A
SY
T
S
I
FQ
-----
P
---------
-
Q
NDR
---
D
S
S
G
KY
-
L
T
P
I
T
GN
N
YE
L
G
L
K
SDWM
N
S
RL
TT
T
L
A
I
FR
IEQD
N
VAQ
STGTPIPG
S
N
G
E
T
A
Y
KA
V
--
D
GT
V
S
KGVE
F
E
LN
---
GAIT
D
N
WQ
L
T
F
G
A
T
RYI
AE
DNEG
N
AV
N
P
N
--
--
--------
L
P
R
T
TVK
MF
T
S
Y
RLP
V
M
P
--
E
LTVG
G
G
V
NW
Q
N
---
R
VYTDT
V
-
T
P
Y
GT
FR
A
EQ
GSY
A
L
VD
L
FT
RY
Q
V
T
K
----
N
F
S
L
Q
G
NVNNLFD
KT
Y
DTN
VEG
S
I
V
-------
---Y
GAPR
N
F
SI
T
G
T
YQ
F
fig|199310.1.peg.1327
Escherichia coli CFT073 (21-729/729)
L
AG
CIA
L
ALLP
SA
A
F
AA
P
VT-
--
E
E
T
V
I
VE
G
S
A
---
T
AP
D
D
GE
----
NDYNVTSTSA
GTK
MQM
T
QR
D
I
PQS
V
T
I
VS
Q
Q
R
M
E
DQQ
LQ
T
L
G
E
VM
E
NT
L
G
I
S
---
-
-
-K
S
Q
A
D
S
D
R
A
LY
Y
S
RGF
-
----
Q
ID
N
Y
M
V
DGI
PT
YFESRWN
L
G
D
----
A
LS
D
MALF
ERVEV
V
RG
A
T
G
LM
T
G
T
G
N
P
S
A
A
INMV
R
K
H
A
T
S
REF
K
G
DVSA
EY
GS
WNKE
R
YVA
D
LQSP
L
T
E
DG
KI
R
A
R
I
V
G
GY
Q
N
N
D
S
WL
D
RYNS
E
KT
FF
SG
IVD
A
D
LG
DLTM
L
SAG
----------
-
-
--Y
E
Y
QRI
D
VNS
PT
W
G
--
-
-G
LP
RW
N
T
DG--
--
S
S
NS
Y
D
RARSTAP
D
W
A
YND
KEI
N
KVF
M
T
--------
L
K
Q
R
F
A
DT
W
Q
A
T
L
N
A
T
H
SEV
E
F
D
S
--
KM
MY
V
D
AY
VNKA
D
GMLVG
P
YS
NYGPGFDY
VGGTGWNSGKRKVD
A
LDLFA
D
GSY
E
L
F
GR
Q
-
-
-
-
-
-
-
-
--
-
-
-
H
N
L
M
---------------
F
G
G
S
Y
S
K
QN
N
RYF
S
S
--------------------
W
A
--
---
-
---
-
--
N
IF-
PD
E
IGSFYNFNG
N
FP
Q
TDWSPQSL
A
QDD
T
T
HMKS
LYA
A
T
RV
T
LADP
L
H
L
I
L
G
A
R
YT
N
W
--
R
V
D
T
L
T
Y
------------
---------
-
-
-----
SMEK
N
HT
T
P
Y
AG
LV
F
D
I
N
DN
W
-
S
T
Y
A
SY
T
S
I
FQ
-----
P
---------
-
Q
NDR
---
D
S
S
G
KY
-
L
T
P
I
T
GN
N
YE
L
G
L
K
SDWM
N
S
RL
TT
T
L
A
I
FR
IEQD
N
VAQ
STGTPIPG
S
N
G
E
T
A
Y
KA
V
--
D
GT
V
S
KGVE
F
E
LN
---
GAIT
D
N
WQ
L
T
F
G
A
T
RYI
AE
DNEG
N
AV
N
P
N
--
--
--------
L
P
R
T
TVK
MF
T
S
Y
RLP
V
M
P
--
E
LTVG
G
G
V
NW
Q
N
---
R
VYTDT
V
-
T
P
Y
GT
FR
A
EQ
GSY
A
L
VD
L
FT
RY
Q
V
T
K
----
N
F
S
L
Q
G
NVNNLFD
KT
Y
DTN
VEG
S
I
V
-------
---Y
GAPR
N
F
SI
T
G
T
YQ
F
fig|199310.4.peg.1303
Escherichia coli CFT073 (21-729/729)
L
AG
CIA
L
ALLP
SA
A
F
AA
P
VT-
--
E
E
T
V
I
VE
G
S
A
---
T
AP
D
D
GE
----
NDYNVTSTSA
GTK
MQM
T
QR
D
I
PQS
V
T
I
VS
Q
Q
R
M
E
DQQ
LQ
T
L
G
E
VM
E
NT
L
G
I
S
---
-
-
-K
S
Q
A
D
S
D
R
A
LY
Y
S
RGF
-
----
Q
ID
N
Y
M
V
DGI
PT
YFESRWN
L
G
D
----
A
LS
D
MALF
ERVEV
V
RG
A
T
G
LM
T
G
T
G
N
P
S
A
A
INMV
R
K
H
A
T
S
REF
K
G
DVSA
EY
GS
WNKE
R
YVA
D
LQSP
L
T
E
DG
KI
R
A
R
I
V
G
GY
Q
N
N
D
S
WL
D
RYNS
E
KT
FF
SG
IVD
A
D
LG
DLTM
L
SAG
----------
-
-
--Y
E
Y
QRI
D
VNS
PT
W
G
--
-
-G
LP
RW
N
T
DG--
--
S
S
NS
Y
D
RARSTAP
D
W
A
YND
KEI
N
KVF
M
T
--------
L
K
Q
R
F
A
DT
W
Q
A
T
L
N
A
T
H
SEV
E
F
D
S
--
KM
MY
V
D
AY
VNKA
D
GMLVG
P
YS
NYGPGFDY
VGGTGWNSGKRKVD
A
LDLFA
D
GSY
E
L
F
GR
Q
-
-
-
-
-
-
-
-
--
-
-
-
H
N
L
M
---------------
F
G
G
S
Y
S
K
QN
N
RYF
S
S
--------------------
W
A
--
---
-
---
-
--
N
IF-
PD
E
IGSFYNFNG
N
FP
Q
TDWSPQSL
A
QDD
T
T
HMKS
LYA
A
T
RV
T
LADP
L
H
L
I
L
G
A
R
YT
N
W
--
R
V
D
T
L
T
Y
------------
---------
-
-
-----
SMEK
N
HT
T
P
Y
AG
LV
F
D
I
N
DN
W
-
S
T
Y
A
SY
T
S
I
FQ
-----
P
---------
-
Q
NDR
---
D
S
S
G
KY
-
L
T
P
I
T
GN
N
YE
L
G
L
K
SDWM
N
S
RL
TT
T
L
A
I
FR
IEQD
N
VAQ
STGTPIPG
S
N
G
E
T
A
Y
KA
V
--
D
GT
V
S
KGVE
F
E
LN
---
GAIT
D
N
WQ
L
T
F
G
A
T
RYI
AE
DNEG
N
AV
N
P
N
--
--
--------
L
P
R
T
TVK
MF
T
S
Y
RLP
V
M
P
--
E
LTVG
G
G
V
NW
Q
N
---
R
VYTDT
V
-
T
P
Y
GT
FR
A
EQ
GSY
A
L
VD
L
FT
RY
Q
V
T
K
----
N
F
S
L
Q
G
NVNNLFD
KT
Y
DTN
VEG
S
I
V
-------
---Y
GAPR
N
F
SI
T
G
T
YQ
F
fig|714962.3.peg.1232
Escherichia coli IHE3034 (21-729/729)
L
AG
CIA
L
ALLP
SA
A
F
AA
P
VT-
--
E
E
T
V
I
VE
G
S
A
---
T
AP
D
D
GE
----
NDYNVTSTSA
GTK
MQM
T
QR
D
I
PQS
V
T
I
VS
Q
Q
R
M
E
DQQ
LQ
T
L
G
E
VM
E
NT
L
G
I
S
---
-
-
-K
S
Q
A
D
S
D
R
A
LY
Y
S
RGF
-
----
Q
ID
N
Y
M
V
DGI
PT
YFESRWN
L
G
D
----
A
LS
D
MALF
ERVEV
V
RG
A
T
G
LM
T
G
T
G
N
P
S
A
A
INMV
R
K
H
A
T
S
REF
K
G
DVSA
EY
GS
WNKE
R
YVA
D
LQSP
L
T
E
DG
KI
R
A
R
I
V
G
GY
Q
N
N
D
S
WL
D
RYNS
E
KT
FF
SG
IVD
A
D
LG
DLTM
L
SAG
----------
-
-
--Y
E
Y
QRI
D
VNS
PT
W
G
--
-
-G
LP
RW
N
T
DG--
--
S
S
NS
Y
D
RARSTAP
D
W
A
YND
KEI
N
KVF
M
T
--------
L
K
Q
R
F
A
DT
W
Q
A
T
L
N
A
T
H
SEV
E
F
D
S
--
KM
MY
V
D
AY
VNKA
D
GMLVG
P
YS
NYGPGFDY
VGGTGWNSGKRKVD
A
LDLFA
D
GSY
E
L
F
GR
Q
-
-
-
-
-
-
-
-
--
-
-
-
H
N
L
M
---------------
F
G
G
S
Y
S
K
QN
N
RYF
S
S
--------------------
W
A
--
---
-
---
-
--
N
IF-
PD
E
IGSFYNFNG
N
FP
Q
TDWSPQSL
A
QDD
T
T
HMKS
LYA
A
T
RV
T
LADP
L
H
L
I
L
G
A
R
YT
N
W
--
R
V
D
T
L
T
Y
------------
---------
-
-
-----
SMEK
N
HT
T
P
Y
AG
LV
F
D
I
N
DN
W
-
S
T
Y
A
SY
T
S
I
FQ
-----
P
---------
-
Q
NDR
---
D
S
S
G
KY
-
L
T
P
I
T
GN
N
YE
L
G
L
K
SDWM
N
S
RL
TT
T
L
A
I
FR
IEQD
N
VAQ
STGTPIPG
S
N
G
E
T
A
Y
KA
V
--
D
GT
V
S
KGVE
F
E
LN
---
GAIT
D
N
WQ
L
T
F
G
A
T
RYI
AE
DNEG
N
AV
N
P
N
--
--
--------
L
P
R
T
TVK
MF
T
S
Y
RLP
V
M
P
--
E
LTVG
G
G
V
NW
Q
N
---
R
VYTDT
V
-
T
P
Y
GT
FR
A
EQ
GSY
A
L
VD
L
FT
RY
Q
V
T
K
----
N
F
S
L
Q
G
NVNNLFD
KT
Y
DTN
VEG
S
I
V
-------
---Y
GAPR
N
F
SI
T
G
T
YQ
F
fig|749546.3.peg.4794
Escherichia coli MS 185-1 (21-729/729)
L
AG
CIA
L
ALLP
SA
A
F
AA
P
VT-
--
E
E
T
V
I
VE
G
S
A
---
T
AP
D
D
GE
----
NDYNVTSTSA
GTK
MQM
T
QR
D
I
PQS
V
T
I
VS
Q
Q
R
M
E
DQQ
LQ
T
L
G
E
VM
E
NT
L
G
I
S
---
-
-
-K
S
Q
A
D
S
D
R
A
LY
Y
S
RGF
-
----
Q
ID
N
Y
M
V
DGI
PT
YFESRWN
L
G
D
----
A
LS
D
MALF
ERVEV
V
RG
A
T
G
LM
T
G
T
G
N
P
S
A
A
INMV
R
K
H
A
T
S
REF
K
G
DVSA
EY
GS
WNKE
R
YVA
D
LQSP
L
T
E
DG
KI
R
A
R
I
V
G
GY
Q
N
N
D
S
WL
D
RYNS
E
KT
FF
SG
IVD
A
D
LG
DLTM
L
SAG
----------
-
-
--Y
E
Y
QRI
D
VNS
PT
W
G
--
-
-G
LP
RW
N
T
DG--
--
S
S
NS
Y
D
RARSTAP
D
W
A
YND
KEI
N
KVF
M
T
--------
L
K
Q
R
F
A
DT
W
Q
A
T
L
N
A
T
H
SEV
E
F
D
S
--
KM
MY
V
D
AY
VNKA
D
GMLVG
P
YS
NYGPGFDY
VGGTGWNSGKRKVD
A
LDLFA
D
GSY
E
L
F
GR
Q
-
-
-
-
-
-
-
-
--
-
-
-
H
N
L
M
---------------
F
G
G
S
Y
S
K
QN
N
RYF
S
S
--------------------
W
A
--
---
-
---
-
--
N
IF-
PD
E
IGSFYNFNG
N
FP
Q
TDWSPQSL
A
QDD
T
T
HMKS
LYA
A
T
RV
T
LADP
L
H
L
I
L
G
A
R
YT
N
W
--
R
V
D
T
L
T
Y
------------
---------
-
-
-----
SMEK
N
HT
T
P
Y
AG
LV
F
D
I
N
DN
W
-
S
T
Y
A
SY
T
S
I
FQ
-----
P
---------
-
Q
NDR
---
D
S
S
G
KY
-
L
T
P
I
T
GN
N
YE
L
G
L
K
SDWM
N
S
RL
TT
T
L
A
I
FR
IEQD
N
VAQ
STGTPIPG
S
N
G
E
T
A
Y
KA
V
--
D
GT
V
S
KGVE
F
E
LN
---
GAIT
D
N
WQ
L
T
F
G
A
T
RYI
AE
DNEG
N
AV
N
P
N
--
--
--------
L
P
R
T
TVK
MF
T
S
Y
RLP
V
M
P
--
E
LTVG
G
G
V
NW
Q
N
---
R
VYTDT
V
-
T
P
Y
GT
FR
A
EQ
GSY
A
L
VD
L
FT
RY
Q
V
T
K
----
N
F
S
L
Q
G
NVNNLFD
KT
Y
DTN
VEG
S
I
V
-------
---Y
GAPR
N
F
SI
T
G
T
YQ
F
fig|749528.3.peg.745
Escherichia coli MS 45-1 (21-729/729)
L
AG
CIA
L
ALLP
SA
A
F
AA
P
VT-
--
E
E
T
V
I
VE
G
S
A
---
T
AP
D
D
GE
----
NDYNVTSTSA
GTK
MQM
T
QR
D
I
PQS
V
T
I
VS
Q
Q
R
M
E
DQQ
LQ
T
L
G
E
VM
E
NT
L
G
I
S
---
-
-
-K
S
Q
A
D
S
D
R
A
LY
Y
S
RGF
-
----
Q
ID
N
Y
M
V
DGI
PT
YFESRWN
L
G
D
----
A
LS
D
MALF
ERVEV
V
RG
A
T
G
LM
T
G
T
G
N
P
S
A
A
INMV
R
K
H
A
T
S
REF
K
G
DVSA
EY
GS
WNKE
R
YVA
D
LQSP
L
T
E
DG
KI
R
A
R
I
V
G
GY
Q
N
N
D
S
WL
D
RYNS
E
KT
FF
SG
IVD
A
D
LG
DLTM
L
SAG
----------
-
-
--Y
E
Y
QRI
D
VNS
PT
W
G
--
-
-G
LP
RW
N
T
DG--
--
S
S
NS
Y
D
RARSTAP
D
W
A
YND
KEI
N
KVF
M
T
--------
L
K
Q
R
F
A
DT
W
Q
A
T
L
N
A
T
H
SEV
E
F
D
S
--
KM
MY
V
D
AY
VNKA
D
GMLVG
P
YS
NYGPGFDY
VGGTGWNSGKRKVD
A
LDLFA
D
GSY
E
L
F
GR
Q
-
-
-
-
-
-
-
-
--
-
-
-
H
N
L
M
---------------
F
G
G
S
Y
S
K
QN
N
RYF
S
S
--------------------
W
A
--
---
-
---
-
--
N
IF-
PD
E
IGSFYNFNG
N
FP
Q
TDWSPQSL
A
QDD
T
T
HMKS
LYA
A
T
RV
T
LADP
L
H
L
I
L
G
A
R
YT
N
W
--
R
V
D
T
L
T
Y
------------
---------
-
-
-----
SMEK
N
HT
T
P
Y
AG
LV
F
D
I
N
DN
W
-
S
T
Y
A
SY
T
S
I
FQ
-----
P
---------
-
Q
NDR
---
D
S
S
G
KY
-
L
T
P
I
T
GN
N
YE
L
G
L
K
SDWM
N
S
RL
TT
T
L
A
I
FR
IEQD
N
VAQ
STGTPIPG
S
N
G
E
T
A
Y
KA
V
--
D
GT
V
S
KGVE
F
E
LN
---
GAIT
D
N
WQ
L
T
F
G
A
T
RYI
AE
DNEG
N
AV
N
P
N
--
--
--------
L
P
R
T
TVK
MF
T
S
Y
RLP
V
M
P
--
E
LTVG
G
G
V
NW
Q
N
---
R
VYTDT
V
-
T
P
Y
GT
FR
A
EQ
GSY
A
L
VD
L
FT
RY
Q
V
T
K
----
N
F
S
L
Q
G
NVNNLFD
KT
Y
DTN
VEG
S
I
V
-------
---Y
GAPR
N
F
SI
T
G
T
YQ
F
fig|585035.6.peg.1122
Escherichia coli S88 (21-729/729)
L
AG
CIA
L
ALLP
SA
A
F
AA
P
VT-
--
E
E
T
V
I
VE
G
S
A
---
T
AP
D
D
GE
----
NDYNVTSTSA
GTK
MQM
T
QR
D
I
PQS
V
T
I
VS
Q
Q
R
M
E
DQQ
LQ
T
L
G
E
VM
E
NT
L
G
I
S
---
-
-
-K
S
Q
A
D
S
D
R
A
LY
Y
S
RGF
-
----
Q
ID
N
Y
M
V
DGI
PT
YFESRWN
L
G
D
----
A
LS
D
MALF
ERVEV
V
RG
A
T
G
LM
T
G
T
G
N
P
S
A
A
INMV
R
K
H
A
T
S
REF
K
G
DVSA
EY
GS
WNKE
R
YVA
D
LQSP
L
T
E
DG
KI
R
A
R
I
V
G
GY
Q
N
N
D
S
WL
D
RYNS
E
KT
FF
SG
IVD
A
D
LG
DLTM
L
SAG
----------
-
-
--Y
E
Y
QRI
D
VNS
PT
W
G
--
-
-G
LP
RW
N
T
DG--
--
S
S
NS
Y
D
RARSTAP
D
W
A
YND
KEI
N
KVF
M
T
--------
L
K
Q
R
F
A
DT
W
Q
A
T
L
N
A
T
H
SEV
E
F
D
S
--
KM
MY
V
D
AY
VNKA
D
GMLVG
P
YS
NYGPGFDY
VGGTGWNSGKRKVD
A
LDLFA
D
GSY
E
L
F
GR
Q
-
-
-
-
-
-
-
-
--
-
-
-
H
N
L
M
---------------
F
G
G
S
Y
S
K
QN
N
RYF
S
S
--------------------
W
A
--
---
-
---
-
--
N
IF-
PD
E
IGSFYNFNG
N
FP
Q
TDWSPQSL
A
QDD
T
T
HMKS
LYA
A
T
RV
T
LADP
L
H
L
I
L
G
A
R
YT
N
W
--
R
V
D
T
L
T
Y
------------
---------
-
-
-----
SMEK
N
HT
T
P
Y
AG
LV
F
D
I
N
DN
W
-
S
T
Y
A
SY
T
S
I
FQ
-----
P
---------
-
Q
NDR
---
D
S
S
G
KY
-
L
T
P
I
T
GN
N
YE
L
G
L
K
SDWM
N
S
RL
TT
T
L
A
I
FR
IEQD
N
VAQ
STGTPIPG
S
N
G
E
T
A
Y
KA
V
--
D
GT
V
S
KGVE
F
E
LN
---
GAIT
D
N
WQ
L
T
F
G
A
T
RYI
AE
DNEG
N
AV
N
P
N
--
--
--------
L
P
R
T
TVK
MF
T
S
Y
RLP
V
M
P
--
E
LTVG
G
G
V
NW
Q
N
---
R
VYTDT
V
-
T
P
Y
GT
FR
A
EQ
GSY
A
L
VD
L
FT
RY
Q
V
T
K
----
N
F
S
L
Q
G
NVNNLFD
KT
Y
DTN
VEG
S
I
V
-------
---Y
GAPR
N
F
SI
T
G
T
YQ
F
fig|869729.3.peg.2519
Escherichia coli UM146 (21-729/729)
L
AG
CIA
L
ALLP
SA
A
F
AA
P
VT-
--
E
E
T
V
I
VE
G
S
A
---
T
AP
D
D
GE
----
NDYNVTSTSA
GTK
MQM
T
QR
D
I
PQS
V
T
I
VS
Q
Q
R
M
E
DQQ
LQ
T
L
G
E
VM
E
NT
L
G
I
S
---
-
-
-K
S
Q
A
D
S
D
R
A
LY
Y
S
RGF
-
----
Q
ID
N
Y
M
V
DGI
PT
YFESRWN
L
G
D
----
A
LS
D
MALF
ERVEV
V
RG
A
T
G
LM
T
G
T
G
N
P
S
A
A
INMV
R
K
H
A
T
S
REF
K
G
DVSA
EY
GS
WNKE
R
YVA
D
LQSP
L
T
E
DG
KI
R
A
R
I
V
G
GY
Q
N
N
D
S
WL
D
RYNS
E
KT
FF
SG
IVD
A
D
LG
DLTM
L
SAG
----------
-
-
--Y
E
Y
QRI
D
VNS
PT
W
G
--
-
-G
LP
RW
N
T
DG--
--
S
S
NS
Y
D
RARSTAP
D
W
A
YND
KEI
N
KVF
M
T
--------
L
K
Q
R
F
A
DT
W
Q
A
T
L
N
A
T
H
SEV
E
F
D
S
--
KM
MY
V
D
AY
VNKA
D
GMLVG
P
YS
NYGPGFDY
VGGTGWNSGKRKVD
A
LDLFA
D
GSY
E
L
F
GR
Q
-
-
-
-
-
-
-
-
--
-
-
-
H
N
L
M
---------------
F
G
G
S
Y
S
K
QN
N
RYF
S
S
--------------------
W
A
--
---
-
---
-
--
N
IF-
PD
E
IGSFYNFNG
N
FP
Q
TDWSPQSL
A
QDD
T
T
HMKS
LYA
A
T
RV
T
LADP
L
H
L
I
L
G
A
R
YT
N
W
--
R
V
D
T
L
T
Y
------------
---------
-
-
-----
SMEK
N
HT
T
P
Y
AG
LV
F
D
I
N
DN
W
-
S
T
Y
A
SY
T
S
I
FQ
-----
P
---------
-
Q
NDR
---
D
S
S
G
KY
-
L
T
P
I
T
GN
N
YE
L
G
L
K
SDWM
N
S
RL
TT
T
L
A
I
FR
IEQD
N
VAQ
STGTPIPG
S
N
G
E
T
A
Y
KA
V
--
D
GT
V
S
KGVE
F
E
LN
---
GAIT
D
N
WQ
L
T
F
G
A
T
RYI
AE
DNEG
N
AV
N
P
N
--
--
--------
L
P
R
T
TVK
MF
T
S
Y
RLP
V
M
P
--
E
LTVG
G
G
V
NW
Q
N
---
R
VYTDT
V
-
T
P
Y
GT
FR
A
EQ
GSY
A
L
VD
L
FT
RY
Q
V
T
K
----
N
F
S
L
Q
G
NVNNLFD
KT
Y
DTN
VEG
S
I
V
-------
---Y
GAPR
N
F
SI
T
G
T
YQ
F
fig|364106.7.peg.1305
Escherichia coli UTI89 (21-729/729)
L
AG
CIA
L
ALLP
SA
A
F
AA
P
VT-
--
E
E
T
V
I
VE
G
S
A
---
T
AP
D
D
GE
----
NDYNVTSTSA
GTK
MQM
T
QR
D
I
PQS
V
T
I
VS
Q
Q
R
M
E
DQQ
LQ
T
L
G
E
VM
E
NT
L
G
I
S
---
-
-
-K
S
Q
A
D
S
D
R
A
LY
Y
S
RGF
-
----
Q
ID
N
Y
M
V
DGI
PT
YFESRWN
L
G
D
----
A
LS
D
MALF
ERVEV
V
RG
A
T
G
LM
T
G
T
G
N
P
S
A
A
INMV
R
K
H
A
T
S
REF
K
G
DVSA
EY
GS
WNKE
R
YVA
D
LQSP
L
T
E
DG
KI
R
A
R
I
V
G
GY
Q
N
N
D
S
WL
D
RYNS
E
KT
FF
SG
IVD
A
D
LG
DLTM
L
SAG
----------
-
-
--Y
E
Y
QRI
D
VNS
PT
W
G
--
-
-G
LP
RW
N
T
DG--
--
S
S
NS
Y
D
RARSTAP
D
W
A
YND
KEI
N
KVF
M
T
--------
L
K
Q
R
F
A
DT
W
Q
A
T
L
N
A
T
H
SEV
E
F
D
S
--
KM
MY
V
D
AY
VNKA
D
GMLVG
P
YS
NYGPGFDY
VGGTGWNSGKRKVD
A
LDLFA
D
GSY
E
L
F
GR
Q
-
-
-
-
-
-
-
-
--
-
-
-
H
N
L
M
---------------
F
G
G
S
Y
S
K
QN
N
RYF
S
S
--------------------
W
A
--
---
-
---
-
--
N
IF-
PD
E
IGSFYNFNG
N
FP
Q
TDWSPQSL
A
QDD
T
T
HMKS
LYA
A
T
RV
T
LADP
L
H
L
I
L
G
A
R
YT
N
W
--
R
V
D
T
L
T
Y
------------
---------
-
-
-----
SMEK
N
HT
T
P
Y
AG
LV
F
D
I
N
DN
W
-
S
T
Y
A
SY
T
S
I
FQ
-----
P
---------
-
Q
NDR
---
D
S
S
G
KY
-
L
T
P
I
T
GN
N
YE
L
G
L
K
SDWM
N
S
RL
TT
T
L
A
I
FR
IEQD
N
VAQ
STGTPIPG
S
N
G
E
T
A
Y
KA
V
--
D
GT
V
S
KGVE
F
E
LN
---
GAIT
D
N
WQ
L
T
F
G
A
T
RYI
AE
DNEG
N
AV
N
P
N
--
--
--------
L
P
R
T
TVK
MF
T
S
Y
RLP
V
M
P
--
E
LTVG
G
G
V
NW
Q
N
---
R
VYTDT
V
-
T
P
Y
GT
FR
A
EQ
GSY
A
L
VD
L
FT
RY
Q
V
T
K
----
N
F
S
L
Q
G
NVNNLFD
KT
Y
DTN
VEG
S
I
V
-------
---Y
GAPR
N
F
SI
T
G
T
YQ
F
fig|364106.8.peg.1304
Escherichia coli UTI89 (21-729/729)
L
AG
CIA
L
ALLP
SA
A
F
AA
P
VT-
--
E
E
T
V
I
VE
G
S
A
---
T
AP
D
D
GE
----
NDYNVTSTSA
GTK
MQM
T
QR
D
I
PQS
V
T
I
VS
Q
Q
R
M
E
DQQ
LQ
T
L
G
E
VM
E
NT
L
G
I
S
---
-
-
-K
S
Q
A
D
S
D
R
A
LY
Y
S
RGF
-
----
Q
ID
N
Y
M
V
DGI
PT
YFESRWN
L
G
D
----
A
LS
D
MALF
ERVEV
V
RG
A
T
G
LM
T
G
T
G
N
P
S
A
A
INMV
R
K
H
A
T
S
REF
K
G
DVSA
EY
GS
WNKE
R
YVA
D
LQSP
L
T
E
DG
KI
R
A
R
I
V
G
GY
Q
N
N
D
S
WL
D
RYNS
E
KT
FF
SG
IVD
A
D
LG
DLTM
L
SAG
----------
-
-
--Y
E
Y
QRI
D
VNS
PT
W
G
--
-
-G
LP
RW
N
T
DG--
--
S
S
NS
Y
D
RARSTAP
D
W
A
YND
KEI
N
KVF
M
T
--------
L
K
Q
R
F
A
DT
W
Q
A
T
L
N
A
T
H
SEV
E
F
D
S
--
KM
MY
V
D
AY
VNKA
D
GMLVG
P
YS
NYGPGFDY
VGGTGWNSGKRKVD
A
LDLFA
D
GSY
E
L
F
GR
Q
-
-
-
-
-
-
-
-
--
-
-
-
H
N
L
M
---------------
F
G
G
S
Y
S
K
QN
N
RYF
S
S
--------------------
W
A
--
---
-
---
-
--
N
IF-
PD
E
IGSFYNFNG
N
FP
Q
TDWSPQSL
A
QDD
T
T
HMKS
LYA
A
T
RV
T
LADP
L
H
L
I
L
G
A
R
YT
N
W
--
R
V
D
T
L
T
Y
------------
---------
-
-
-----
SMEK
N
HT
T
P
Y
AG
LV
F
D
I
N
DN
W
-
S
T
Y
A
SY
T
S
I
FQ
-----
P
---------
-
Q
NDR
---
D
S
S
G
KY
-
L
T
P
I
T
GN
N
YE
L
G
L
K
SDWM
N
S
RL
TT
T
L
A
I
FR
IEQD
N
VAQ
STGTPIPG
S
N
G
E
T
A
Y
KA
V
--
D
GT
V
S
KGVE
F
E
LN
---
GAIT
D
N
WQ
L
T
F
G
A
T
RYI
AE
DNEG
N
AV
N
P
N
--
--
--------
L
P
R
T
TVK
MF
T
S
Y
RLP
V
M
P
--
E
LTVG
G
G
V
NW
Q
N
---
R
VYTDT
V
-
T
P
Y
GT
FR
A
EQ
GSY
A
L
VD
L
FT
RY
Q
V
T
K
----
N
F
S
L
Q
G
NVNNLFD
KT
Y
DTN
VEG
S
I
V
-------
---Y
GAPR
N
F
SI
T
G
T
YQ
F
fig|562.376.peg.89
Escherichia coli WV_060327 (21-729/729)
L
AG
CIA
L
ALLP
SA
A
F
AA
P
VT-
--
E
E
T
V
I
VE
G
S
A
---
T
AP
D
D
GE
----
NDYNVTSTSA
GTK
MQM
T
QR
D
I
PQS
V
T
I
VS
Q
Q
R
M
E
DQQ
LQ
T
L
G
E
VM
E
NT
L
G
I
S
---
-
-
-K
S
Q
A
D
S
D
R
A
LY
Y
S
RGF
-
----
Q
ID
N
Y
M
V
DGI
PT
YFESRWN
L
G
D
----
A
LS
D
MALF
ERVEV
V
RG
A
T
G
LM
T
G
T
G
N
P
S
A
A
INMV
R
K
H
A
T
S
REF
K
G
DVSA
EY
GS
WNKE
R
YVA
D
LQSP
L
T
E
DG
KI
R
A
R
I
V
G
GY
Q
N
N
D
S
WL
D
RYNS
E
KT
FF
SG
IVD
A
D
LG
DLTM
L
SAG
----------
-
-
--Y
E
Y
QRI
D
VNS
PT
W
G
--
-
-G
LP
RW
N
T
DG--
--
S
S
NS
Y
D
RARSTAP
D
W
A
YND
KEI
N
KVF
M
T
--------
L
K
Q
R
F
A
DT
W
Q
A
T
L
N
A
T
H
SEV
E
F
D
S
--
KM
MY
V
D
AY
VNKA
D
GMLVG
P
YS
NYGPGFDY
VGGTGWNSGKRKVD
A
LDLFA
D
GSY
E
L
F
GR
Q
-
-
-
-
-
-
-
-
--
-
-
-
H
N
L
M
---------------
F
G
G
S
Y
S
K
QN
N
RYF
S
S
--------------------
W
A
--
---
-
---
-
--
N
IF-
PD
E
IGSFYNFNG
N
FP
Q
TDWSPQSL
A
QDD
T
T
HMKS
LYA
A
T
RV
T
LADP
L
H
L
I
L
G
A
R
YT
N
W
--
R
V
D
T
L
T
Y
------------
---------
-
-
-----
SMEK
N
HT
T
P
Y
AG
LV
F
D
I
N
DN
W
-
S
T
Y
A
SY
T
S
I
FQ
-----
P
---------
-
Q
NDR
---
D
S
S
G
KY
-
L
T
P
I
T
GN
N
YE
L
G
L
K
SDWM
N
S
RL
TT
T
L
A
I
FR
IEQD
N
VAQ
STGTPIPG
S
N
G
E
T
A
Y
KA
V
--
D
GT
V
S
KGVE
F
E
LN
---
GAIT
D
N
WQ
L
T
F
G
A
T
RYI
AE
DNEG
N
AV
N
P
N
--
--
--------
L
P
R
T
TVK
MF
T
S
Y
RLP
V
M
P
--
E
LTVG
G
G
V
NW
Q
N
---
R
VYTDT
V
-
T
P
Y
GT
FR
A
EQ
GSY
A
L
VD
L
FT
RY
Q
V
T
K
----
N
F
S
L
Q
G
NVNNLFD
KT
Y
DTN
VEG
S
I
V
-------
---Y
GAPR
N
F
SI
T
G
T
YQ
F
fig|670897.3.peg.1083
Escherichia coli 2362-75 (2-627/627)
I
K
K
ASLL
T
A
C
SVT
A
FSAW
AQ
D
T
S
--
---
--
P
DTL
V
V
T
A
N
R
---
-
------
----
----------
---
FQQ
P
VN
T
V
LAPTD
I
V
T
R
E
D
I
Q
RW
Q
SK
D
L
N
DVM
S
H
L
PGV
N
---
I
S
QT
G
G
M
G
T
S
S
S
LY
V
-
RG
TE
SRHV
L
V-
-
-
L
IDG
V
PM
---
A
R
AG
I
D
N
AIDI
S
QF
P
VSLV
Q
RVE
Y
IRGP
R
S
AV
YG
S
G
A
I
G
G
V
V
N
I
I
T
M
S
NDE
KA-
-
-
Q
IN
A
GM
G
T
NGYQ
A
YDG
V
INKR
F
G
D
T
M
VT
A
-
--
A
G
AY
QT
T
KG
--
-
----
---
--
--
---
F
N
I
Q
PGSP
-
---
----------
-
-
---
--
---
-
---
--
-
-
--
-
--
--
--
--
----
--
Y
SG
D
S
D
R------
-
-
---
D
GYR
N
KLF
WG
-------
G
L
Q
H
K
FND
N
F
S
G
F
F
R
G
YSYTAN
N
D
Y
DQ
GS
MYG
-
-
-
----
-
-----
-
--
--------
--------------
-
-SATG
N
EEA
Q
N
Y
NQ
SW
D
T
G
L
R
Y
N
S
G
I
Y
S
S
Q
L
I
---------------
--A
N
Y
Q
R
LK
N
YNY
T
N
NLGRYAGDATLDDMEQRYIQ
WG
--
---
-
---
-
--
N
SIE
VGH
GAISGGIDW
K
QE
K
LTSSSITK
S
DDY
E
R
DTTG
LY
L
T
G
QQ
Q
ISNV
T
L
E
A
S
G
-
-
--
-
-
--
R
E
D
H
DE
Q
F
G
WH
G
-------
---------
-
-
-----
----
-
--
TW
Q
TA
AG
W
E
F
I
D
GY
-
Q
A
T
L
SY
G
T
SF
L
----
S
P
SL
G
QQYGA
A
R
F
ASI
YGP
G
I
A
A
NP
N
LK
P
E
E
S
K
Q
W
EIG
I
E
G--V
T
G
T
L
DW
R
L
S
G
Y
R
YEIQ
N
LID
-----
YKS
I
N
N
VNQ
Y
IN
V
--
K
SA
T
I
KG
L
E
WT
GN
ITT
G
P
V
E
H
RLT
L
-
---Q
YVD
PR
DDET
D
KV
LYR
RA
K
Q
--------
-
---
---
-QV
K
Y
ELT
G
Q
AY
-
G
FEWD
V
S
Y
Q
Y
I
G
--
Q
R
YDNAY
D
E
T
S
G
S
S
HT
V
KL
G
GV
S
L
W
D
L
AV
A
Y
P
V
T
S
----
H
L
T
V
R
G
K
I
A
NLFD
KD
Y
E
T
V
---
-
-
-
-------
YGYQ
T
A
G
R
E
Y
TL
S
G
S
YT
F
fig|656419.3.peg.5085
Escherichia coli M718 (2-627/627)
I
K
K
ASLL
T
A
C
SVT
A
FSAW
AQ
D
T
S
--
---
--
P
DTL
V
V
T
A
N
R
---
-
------
----
----------
---
FQQ
P
VN
T
V
LAPTD
I
V
T
R
E
D
I
Q
RW
Q
SK
D
L
N
DVM
S
H
L
PGV
N
---
I
S
QT
G
G
M
G
T
S
S
S
LY
V
-
RG
TE
SRHV
L
V-
-
-
L
IDG
V
PM
---
A
R
AG
I
D
N
AIDI
S
QF
P
VSLV
Q
RVE
Y
IRGP
R
S
AV
YG
S
G
A
I
G
G
V
V
N
I
I
T
M
S
NDE
KA-
-
-
Q
IN
A
GM
G
T
NGYQ
A
YDG
V
INKR
F
G
D
T
M
VT
A
-
--
A
G
AY
QT
T
KG
--
-
----
---
--
--
---
F
N
I
Q
PGSP
-
---
----------
-
-
---
--
---
-
---
--
-
-
--
-
--
--
--
--
----
--
Y
SG
D
S
D
R------
-
-
---
D
GYR
N
KLF
WG
-------
G
L
Q
H
K
FND
N
F
S
G
F
F
R
G
YSYTAN
N
D
Y
DQ
GS
MYG
-
-
-
----
-
-----
-
--
--------
--------------
-
-SATG
N
EEA
Q
N
Y
NQ
SW
D
T
G
L
R
Y
N
S
G
I
Y
S
S
Q
L
I
---------------
--A
N
Y
Q
R
LK
N
YNY
T
N
NLGRYAGDATLDDMEQRYIQ
WG
--
---
-
---
-
--
N
SIE
VGH
GAISGGIDW
K
QE
K
LTSSSITK
S
DDY
E
R
DTTG
LY
L
T
G
QQ
Q
ISNV
T
L
E
A
S
G
-
-
--
-
-
--
R
E
D
H
DE
Q
F
G
WH
G
-------
---------
-
-
-----
----
-
--
TW
Q
TA
AG
W
E
F
I
D
GY
-
Q
A
T
L
SY
G
T
SF
L
----
S
P
SL
G
QQYGA
A
R
F
ASI
YGP
G
I
A
A
NP
N
LK
P
E
E
S
K
Q
W
EIG
I
E
G--V
T
G
T
L
DW
R
L
S
G
Y
R
YEIQ
N
LID
-----
YKS
I
N
N
VNQ
Y
IN
V
--
K
SA
T
I
KG
L
E
WT
GN
ITT
G
P
V
E
H
RLT
L
-
---Q
YVD
PR
DDET
D
KV
LYR
RA
K
Q
--------
-
---
---
-QV
K
Y
ELT
G
Q
AY
-
G
FEWD
V
S
Y
Q
Y
I
G
--
Q
R
YDNAY
D
E
T
S
G
S
S
HT
V
KL
G
GV
S
L
W
D
L
AV
A
Y
P
V
T
S
----
H
L
T
V
R
G
K
I
A
NLFD
KD
Y
E
T
V
---
-
-
-
-------
YGYQ
T
A
G
R
E
Y
TL
S
G
S
YT
F
fig|216593.1.peg.4815
Escherichia coli E2348/69 (17-642/642)
I
K
K
ASLL
T
A
C
SVT
A
FSAW
AQ
D
T
S
--
---
--
P
DTL
V
V
T
A
N
R
---
-
------
----
----------
---
FQQ
P
VN
T
V
LAPTD
I
V
T
R
E
D
I
Q
RW
Q
SK
D
L
N
DVM
S
H
L
PGV
N
---
I
S
QT
G
G
M
G
T
S
S
S
LY
V
-
RG
TE
SRHV
L
V-
-
-
L
IDG
V
PM
---
A
R
AG
I
D
N
AIDI
S
QF
P
VSLV
Q
RVE
Y
IRGP
R
S
AV
YG
S
G
A
I
G
G
V
V
N
I
I
T
M
S
NDE
KA-
-
-
Q
IN
A
GM
G
T
NGYQ
A
YDG
V
INKR
F
G
D
T
M
VT
A
-
--
A
G
AY
QT
T
KG
--
-
----
---
--
--
---
F
N
I
Q
PGSP
-
---
----------
-
-
---
--
---
-
---
--
-
-
--
-
--
--
--
--
----
--
Y
SG
D
S
D
R------
-
-
---
D
GYR
N
KLF
WG
-------
G
L
Q
H
K
FND
N
F
S
G
F
F
R
G
YSYTAN
N
D
Y
DQ
GS
MYG
-
-
-
----
-
-----
-
--
--------
--------------
-
-SATG
N
EEA
Q
N
Y
NQ
SW
D
T
G
L
R
Y
N
S
G
I
Y
S
S
Q
L
I
---------------
--A
N
Y
Q
R
LK
N
YNY
T
N
NLGRYAGDATLDDMEQRYIQ
WG
--
---
-
---
-
--
N
SIE
VGH
GAISGGIDW
K
QE
K
LTSSSITK
S
DDY
E
R
DTTG
LY
L
T
G
QQ
Q
ISNV
T
L
E
A
S
G
-
-
--
-
-
--
R
E
D
H
DE
Q
F
G
WH
G
-------
---------
-
-
-----
----
-
--
TW
Q
TA
AG
W
E
F
I
D
GY
-
Q
A
T
L
SY
G
T
SF
L
----
S
P
SL
G
QQYGA
A
R
F
ASI
YGP
G
I
A
A
NP
N
LK
P
E
E
S
K
Q
W
EIG
I
E
G--V
T
G
T
L
DW
R
L
S
G
Y
R
YEIQ
N
LID
-----
YKS
I
N
N
VNQ
Y
IN
V
--
K
SA
T
I
KG
L
E
WT
GN
ITT
G
P
V
E
H
RLT
L
-
---Q
YVD
PR
DDET
D
KV
LYR
RA
K
Q
--------
-
---
---
-QV
K
Y
ELT
G
Q
AY
-
G
FEWD
V
S
Y
Q
Y
I
G
--
Q
R
YDNAY
D
E
T
S
G
S
S
HT
V
KL
G
GV
S
L
W
E
L
AV
A
Y
P
V
T
S
----
H
L
T
V
R
G
K
I
A
NLFD
KD
Y
E
T
V
---
-
-
-
-------
YGYQ
T
A
G
R
E
Y
TL
S
G
S
YT
F
fig|574521.7.peg.4380
Escherichia coli O127:H6 str. E2348/69 (2-627/627)
I
K
K
ASLL
T
A
C
SVT
A
FSAW
AQ
D
T
S
--
---
--
P
DTL
V
V
T
A
N
R
---
-
------
----
----------
---
FQQ
P
VN
T
V
LAPTD
I
V
T
R
E
D
I
Q
RW
Q
SK
D
L
N
DVM
S
H
L
PGV
N
---
I
S
QT
G
G
M
G
T
S
S
S
LY
V
-
RG
TE
SRHV
L
V-
-
-
L
IDG
V
PM
---
A
R
AG
I
D
N
AIDI
S
QF
P
VSLV
Q
RVE
Y
IRGP
R
S
AV
YG
S
G
A
I
G
G
V
V
N
I
I
T
M
S
NDE
KA-
-
-
Q
IN
A
GM
G
T
NGYQ
A
YDG
V
INKR
F
G
D
T
M
VT
A
-
--
A
G
AY
QT
T
KG
--
-
----
---
--
--
---
F
N
I
Q
PGSP
-
---
----------
-
-
---
--
---
-
---
--
-
-
--
-
--
--
--
--
----
--
Y
SG
D
S
D
R------
-
-
---
D
GYR
N
KLF
WG
-------
G
L
Q
H
K
FND
N
F
S
G
F
F
R
G
YSYTAN
N
D
Y
DQ
GS
MYG
-
-
-
----
-
-----
-
--
--------
--------------
-
-SATG
N
EEA
Q
N
Y
NQ
SW
D
T
G
L
R
Y
N
S
G
I
Y
S
S
Q
L
I
---------------
--A
N
Y
Q
R
LK
N
YNY
T
N
NLGRYAGDATLDDMEQRYIQ
WG
--
---
-
---
-
--
N
SIE
VGH
GAISGGIDW
K
QE
K
LTSSSITK
S
DDY
E
R
DTTG
LY
L
T
G
QQ
Q
ISNV
T
L
E
A
S
G
-
-
--
-
-
--
R
E
D
H
DE
Q
F
G
WH
G
-------
---------
-
-
-----
----
-
--
TW
Q
TA
AG
W
E
F
I
D
GY
-
Q
A
T
L
SY
G
T
SF
L
----
S
P
SL
G
QQYGA
A
R
F
ASI
YGP
G
I
A
A
NP
N
LK
P
E
E
S
K
Q
W
EIG
I
E
G--V
T
G
T
L
DW
R
L
S
G
Y
R
YEIQ
N
LID
-----
YKS
I
N
N
VNQ
Y
IN
V
--
K
SA
T
I
KG
L
E
WT
GN
ITT
G
P
V
E
H
RLT
L
-
---Q
YVD
PR
DDET
D
KV
LYR
RA
K
Q
--------
-
---
---
-QV
K
Y
ELT
G
Q
AY
-
G
FEWD
V
S
Y
Q
Y
I
G
--
Q
R
YDNAY
D
E
T
S
G
S
S
HT
V
KL
G
GV
S
L
W
E
L
AV
A
Y
P
V
T
S
----
H
L
T
V
R
G
K
I
A
NLFD
KD
Y
E
T
V
---
-
-
-
-------
YGYQ
T
A
G
R
E
Y
TL
S
G
S
YT
F
fig|550677.3.peg.4550
Escherichia coli B354 (2-612/612)
I
K
K
ASLL
T
A
C
SVT
A
FSAW
AQ
D
T
S
--
---
--
P
DTL
V
V
T
A
N
R
---
-
------
----
----------
---
FQQ
P
IN
T
V
LAPTD
I
V
T
R
E
D
I
E
RW
Q
SR
T
V
L
DVM
R
RL
PGV
D
---
V
A
QY
G
G
M
G
Q
S
S
S
L
F
I
-
RG
TE
SKHV
L
V-
-
-
L
V
DGI
PV
---
A
R
PG
I
S
N
SSDID
QI
P
VSLV
Q
R
I
E
Y
IRGP
R
S
AV
YG
S
G
A
I
G
G
V
V
N
I
I
T
M
T
NEE
RS-
-
-
Q
INS
SI
GS
KGYQ
Q
YDG
T
YRQR
F
G
D
T
V
VT
A
-
--
A
G
AY
QT
T
KG
--
-
----
---
--
--
---
F
N
V
Q
PHSS
-
---
----------
-
-
---
--
---
-
---
--
-
-
--
-
--
--
--
--
----
--
Y
SG
D
G
D
R------
-
-
---
D
GYR
N
KLF
WG
-------
GI
EH
K
FND
Q
F
D
G
Y
F
R
G
YGYASN
A
D
Y
DQ
GN
-
W
G
-
-
-
----
-
-----
-
--
--------
--------------
-
-YDGG
N
DEH
Q
N
Y
TQ
SW
D
T
G
L
R
F
N
S
G
V
Y
S
S
Q
L
V
---------------
--
V
N
Y
Q
R
IK
D
YNY
S
S
LTGRYASGYTLDDMEQRYIQ
WG
--
---
-
---
-
--
N
NVI
VGH
GAISAGADW
K
QE
K
LMSFGANG
T
DNY
K
R
NNTG
LY
L
T
G
QQ
Q
IDNI
T
L
E
A
S
G
-
-
--
-
-
--
R
E
D
H
DG
Q
L
G
WH
G
-------
---------
-
-
-----
----
-
--
TW
Q
TA
AG
W
Q
F
V
D
GY
-
K
V
T
L
SY
G
T
G
F
L
----
A
P
SL
G
QQ
F
GAE
R
F
---
---
G
I
A
S
NP
N
LK
P
E
E
S
K
Q
W
E
A
G
L
E
G--L
T
G
P
V
DW
R
L
S
T
Y
R
YKIQ
N
LID
-----
Y
--
-
-
N
NN
TY
FN
V
--
K
SA
T
I
KG
L
E
WT
GN
FTT
G
P
I
D
H
RLT
L
-
---Q
YVD
PR
DDET
D
QQ
LYR
RA
K
Q
--------
-
---
---
-QV
K
Y
ELS
G
E
IY
-
E
L
GWD
V
T
Y
Q
Y
I
G
--
E
R
YDYDY
D
-
-
-
-
S
T
RK
V
KM
G
GL
S
V
W
D
I
GL
S
Y
P
V
T
S
----
H
L
T
V
R
G
K
I
A
NLFD
KD
Y
E
T
V
---
-
-
-
-------
YGYQ
T
A
G
R
E
Y
TL
S
G
S
YT
F
fig|585397.7.peg.4668
Escherichia coli ED1a (2-612/612)
I
K
K
ASLL
T
A
C
SVT
A
FSAW
AQ
D
T
S
--
---
--
P
DTL
V
V
T
A
N
R
---
-
------
----
----------
---
FQQ
P
IN
T
V
LAPTD
I
V
T
R
E
D
I
E
RW
Q
SR
T
V
L
DVM
R
RL
PGV
D
---
V
A
QY
G
G
M
G
Q
S
S
S
L
F
I
-
RG
TE
SKHV
L
V-
-
-
L
V
DGI
PV
---
A
R
PG
I
S
N
SSDID
QI
P
VSLV
Q
R
I
E
Y
IRGP
R
S
AV
YG
S
G
A
I
G
G
V
V
N
I
I
T
M
T
NKE
RS-
-
-
Q
INS
SI
GS
KGYQ
Q
YDG
T
YRQR
F
G
D
T
V
VT
A
-
--
A
G
AY
QT
T
KG
--
-
----
---
--
--
---
F
N
V
Q
PHSS
-
---
----------
-
-
---
--
---
-
---
--
-
-
--
-
--
--
--
--
----
--
Y
SG
D
G
D
R------
-
-
---
D
GYR
N
KLF
WG
-------
GI
EH
K
FND
Q
F
D
G
Y
F
R
G
YGYASN
A
D
Y
DQ
GN
-
W
G
-
-
-
----
-
-----
-
--
--------
--------------
-
-YDGG
N
DEH
Q
N
Y
TQ
SW
D
T
G
L
R
F
N
S
G
V
Y
S
S
Q
L
V
---------------
--
V
N
Y
Q
R
IK
D
YNY
S
S
LTGRYASGYTLDDMEQRYIQ
WG
--
---
-
---
-
--
N
NVI
VGH
GAISAGADW
K
QE
K
LMSFGANG
T
DNY
K
R
NNTG
LY
L
T
G
QQ
Q
IDNI
T
L
E
A
S
G
-
-
--
-
-
--
R
E
D
H
DG
Q
L
G
WH
G
-------
---------
-
-
-----
----
-
--
TW
Q
TA
AG
W
Q
F
V
D
GY
-
K
V
T
L
SY
G
T
G
F
L
----
A
P
SL
G
QQ
F
GAE
R
F
---
---
G
I
A
S
NP
N
LK
P
E
E
S
K
Q
W
E
A
G
L
E
G--L
T
G
P
V
DW
R
L
S
T
Y
R
YKIQ
N
LID
-----
Y
--
-
-
N
NN
TY
FN
V
--
K
SA
T
I
KG
L
E
WT
GN
FTT
G
P
I
D
H
RLT
L
-
---Q
YVD
PR
DDET
D
QQ
LYR
RA
K
Q
--------
-
---
---
-QV
K
Y
ELS
G
E
VY
-
E
L
GWD
V
T
Y
Q
Y
I
G
--
E
R
YDYDY
D
-
-
-
-
S
T
RK
V
KM
G
GL
S
V
W
D
I
GL
S
Y
P
V
T
S
----
H
L
T
V
R
G
K
I
A
NLFD
KD
Y
E
T
V
---
-
-
-
-------
YGYQ
T
A
G
R
E
Y
TL
S
G
S
YT
F
fig|585397.9.peg.4666
Escherichia coli ED1a (2-612/612)
I
K
K
ASLL
T
A
C
SVT
A
FSAW
AQ
D
T
S
--
---
--
P
DTL
V
V
T
A
N
R
---
-
------
----
----------
---
FQQ
P
IN
T
V
LAPTD
I
V
T
R
E
D
I
E
RW
Q
SR
T
V
L
DVM
R
RL
PGV
D
---
V
A
QY
G
G
M
G
Q
S
S
S
L
F
I
-
RG
TE
SKHV
L
V-
-
-
L
V
DGI
PV
---
A
R
PG
I
S
N
SSDID
QI
P
VSLV
Q
R
I
E
Y
IRGP
R
S
AV
YG
S
G
A
I
G
G
V
V
N
I
I
T
M
T
NKE
RS-
-
-
Q
INS
SI
GS
KGYQ
Q
YDG
T
YRQR
F
G
D
T
V
VT
A
-
--
A
G
AY
QT
T
KG
--
-
----
---
--
--
---
F
N
V
Q
PHSS
-
---
----------
-
-
---
--
---
-
---
--
-
-
--
-
--
--
--
--
----
--
Y
SG
D
G
D
R------
-
-
---
D
GYR
N
KLF
WG
-------
GI
EH
K
FND
Q
F
D
G
Y
F
R
G
YGYASN
A
D
Y
DQ
GN
-
W
G
-
-
-
----
-
-----
-
--
--------
--------------
-
-YDGG
N
DEH
Q
N
Y
TQ
SW
D
T
G
L
R
F
N
S
G
V
Y
S
S
Q
L
V
---------------
--
V
N
Y
Q
R
IK
D
YNY
S
S
LTGRYASGYTLDDMEQRYIQ
WG
--
---
-
---
-
--
N
NVI
VGH
GAISAGADW
K
QE
K
LMSFGANG
T
DNY
K
R
NNTG
LY
L
T
G
QQ
Q
IDNI
T
L
E
A
S
G
-
-
--
-
-
--
R
E
D
H
DG
Q
L
G
WH
G
-------
---------
-
-
-----
----
-
--
TW
Q
TA
AG
W
Q
F
V
D
GY
-
K
V
T
L
SY
G
T
G
F
L
----
A
P
SL
G
QQ
F
GAE
R
F
---
---
G
I
A
S
NP
N
LK
P
E
E
S
K
Q
W
E
A
G
L
E
G--L
T
G
P
V
DW
R
L
S
T
Y
R
YKIQ
N
LID
-----
Y
--
-
-
N
NN
TY
FN
V
--
K
SA
T
I
KG
L
E
WT
GN
FTT
G
P
I
D
H
RLT
L
-
---Q
YVD
PR
DDET
D
QQ
LYR
RA
K
Q
--------
-
---
---
-QV
K
Y
ELS
G
E
VY
-
E
L
GWD
V
T
Y
Q
Y
I
G
--
E
R
YDYDY
D
-
-
-
-
S
T
RK
V
KM
G
GL
S
V
W
D
I
GL
S
Y
P
V
T
S
----
H
L
T
V
R
G
K
I
A
NLFD
KD
Y
E
T
V
---
-
-
-
-------
YGYQ
T
A
G
R
E
Y
TL
S
G
S
YT
F
Consen1
Primary consensus
MArnfpArqfHSL
----
tf
Ag
g
aqA
Aae
--
edTl
Veas
---
APqqsa
----
gtK
p
d
pqsmtvvs
q
m
dqq
nl
eal
ntpGv
---
g
g
s
t
d
ly
-
RGf
-
q
n
yidGi
-------
Gs
----
a
D
ErvEvirGp
g
yG
saP
g
iNMvsK
ptn
k
-
dvsa
Gs
r
D
l
ddg
r
rv
G
qt
da
d
ery
ap
f
lg
l
----------
l
qh
d
Pt
G
g
lP
gT
--
sgk
d
d
dynd
n
mr
--------
feh
fnDt
t
r
n
rwsevk
d
--
myg
ay
d
s
--------
r
d
e
f
qt
l
s
f
tg
i
H
l
---------------
tGv
f
r
n
s
--------------------
wg
---
p
-
N
pD
-
n
p
n
qT
lYa
d
q
l
l
gG
r
n
--
ryD
at
------------
t
-----
n
tw
aG
y
l
dNg
-
n
Y
sYa
sfq
-----
P
---------
s
---
s
g
-
faP
kgn
yEiG
K
d
rl
T
Alfr
N
--------
n
egty
v
--
g
r
kGvEie
---
gait
awqv
ggyT
Ae
t
ngn
aq
--------
Peh
lws
Y
d
p
--
ltvG
G
ry
g
---
s
d
-
a
gt
f
GsY
vvDa
rY
v
r
----
n
d
qlnVnNLFD
Yvas
s
y
-------
GapR
f
Tat
F
Consen2
Secondary consensus
pskt
qpk
rkiavv
t
l
sa
vp
nade
tga
psl
d
gewgpa
dp
t
k
trt
siit
e
i
lhg
v
dvm
yvl
i
aff
-
s
a
s
r
ii
s
ad
i
-
m
n
l
yfesrwn
fyndv
qa
i
k
a
s
t
g
a
l
ir
ar
igeaqf
t
q
i
ett
s
n
ns
k
qkt
sg
a
wr
t
-
e
-
e
-
a
n
nns
-
p
afde
d
stnekmvgysl
q
ia
n
q
t
t
t
arne
s
lm
mv
-
s
p
p
nygpgfdy
a
n
l
d
-
-
-
-
--
-
v
f
g
y
k
-
a
dsv
-
p
t
e
s
q
a
t
v
t
t
f
t
l
-
-
htev
ld
cggsgrgaitcp
-
vdt
k
np
g
f
i
e
wv
n
iqe
pggnnfala
q
k
n
dlk
tak
s
n
pi
yn
stgtpipg
d
dt
f
yegd
v
y
fs
anls
vnl
fsa
-
n
kpk
--
dgssslpy
t
mf
v
-
ls
isl
nw
n
sr
v
p
-
n
a
-
la
l
g
l
kvgmag
agh
y
dtn
t
v
ee
v
gn
Consensus 1
(when a gap)
Conservative difference
Consensus 2
(when a gap)
Nonconservative diff.
Other character