┌── Escherichia coli B354   
                                                          ┌─┴── Escherichia coli TA280   
                                                       ┌──┴─┬── Escherichia coli 042 (1)  
                                 ┌─────────────────────┤    └─ Escherichia coli FVEC1302 (5)  
                    ┌────────────┤                     └───────────── Escherichia coli M605 (1)  
               ┌────┤            └── Escherichia coli (1-148/159) 1827-70 (2)  
               │    └┬── Escherichia coli DH1   
          ┌────┤     └─ Escherichia coli K12 (11)  
        ┌─┤    └─ Escherichia coli 53638 (2)  
        │ └────────────────────────┬───────── Escherichia coli (1-159/160) 1044A (25)  
   ┌────┤                          └─ Escherichia coli B185 (1)  
   │    └─┬── Escherichia coli HS (1)  
┌──┤      └┬── Escherichia coli EC4100B (4)  
│  │       └─ fig|1040638.4.peg.5708 O104:H4 str. LB226692 (33)  
┤  └────── Escherichia coli IAI39 (2)  
│                          ┌─ Escherichia coli 2362-75 (7)  
└─────────────────────────┬┴───── Escherichia coli MS 21-1   
                          └─┬── Escherichia coli WV_060327   
                            └┬─ Escherichia coli 83972 (10)  
                             └┬── Escherichia coli APEC O1 (6)  
                              └── Escherichia coli H299   
  

  
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (EC 2.7.6.3)
 (20)
  
 Others 
(1)