fig|1040638.4.peg.5676
Escherichia coli O104:H4 str. LB226692
MTAGDKYIEVMMSTEIKTQV
V
V
L
G
A
GPAGY
S
AA
F
R
C
AD
L
GL
ET
VI
V
------
ERY
N
TLGG
V
CLNVGCIPSKALLH
V
A
KV
I
E
E
AKAL
A
E
-
HG
IVFGE
P
KT
D
I
D
K
I
R
TW
K
E
K
VINQL
-
T
G
G
LA
G
MA
KG
R
K
-
VKV
V
N
GL
GK
F
T
G
A
N
----
TL
E
VE
-
G
EN
G
KT
VI
N
FDN
A
I
IA
A
GSRP
I
--
QLP
F
I
PHE
DPRIWDST
D
AL
E
L
KE
VPERLLV
M
G
G
G
I
IGLE
M
G
T
V
Y
HA
LGS
QI
D
V
VEM
F
D
QV
I
PA
A
D
KD
I
V
-K
V
FTK
R
IS
KK
FN
L
M
L
E
T
K
V
T
AVE
AK
E
---
DG
I
Y
V
T
-
ME
GKK
AP
A
E
PQ
R
Y
--
D
A
V
LVAIGRVPN
G
KN
LD
A
GKA
GVE
V
DDRG
F
I
R
VD
KQL
RTN
V
PHI
F
AIGD
I
VGQPMLAHK
G
VH
EG
H
VAAE
V
I
--
AG
K
K
H
YF
DP
---
KV
IPS
I
A
YT
E
PEVAWVG
L
TE
KE
AK
E
K
GI
S
YE
T
A
T
FP
W
A
AS
GRA
I
A
S
D
CAD
G
MT
KLIFDKES
H
RVIGGAIVG
TN
G
GEL
L
G
EI
G
LAIE
M
---
G
C
D
A
EDIA
L
TIHAHPTL
H
E
SVG
LAAEVFEGSITDLPNPKAKKK
fig|6666666.5357.peg.369
Escherichia coli TY-2482
MTAGDKYIEVMMSTEIKTQV
V
V
L
G
A
GPAGY
S
AA
F
R
C
AD
L
GL
ET
VI
V
------
ERY
N
TLGG
V
CLNVGCIPSKALLH
V
A
KV
I
E
E
AKAL
A
E
-
HG
IVFGE
P
KT
D
I
D
K
I
R
TW
K
E
K
VINQL
-
T
G
G
LA
G
MA
KG
R
K
-
VKV
V
N
GL
GK
F
T
G
A
N
----
TL
E
VE
-
G
EN
G
KT
VI
N
FDN
A
I
IA
A
GSRP
I
--
QLP
F
I
PHE
DPRIWDST
D
AL
E
L
KE
VPERLLV
M
G
G
G
I
IGLE
M
G
T
V
Y
HA
LGS
QI
D
V
VEM
F
D
QV
I
PA
A
D
KD
I
V
-K
V
FTK
R
IS
KK
FN
L
M
L
E
T
K
V
T
AVE
AK
E
---
DG
I
Y
V
T
-
ME
GKK
AP
A
E
PQ
R
Y
--
D
A
V
LVAIGRVPN
G
KN
LD
A
GKA
GVE
V
DDRG
F
I
R
VD
KQL
RTN
V
PHI
F
AIGD
I
VGQPMLAHK
G
VH
EG
H
VAAE
V
I
--
AG
K
K
H
YF
DP
---
KV
IPS
I
A
YT
E
PEVAWVG
L
TE
KE
AK
E
K
GI
S
YE
T
A
T
FP
W
A
AS
GRA
I
A
S
D
CAD
G
MT
KLIFDKES
H
RVIGGAIVG
TN
G
GEL
L
G
EI
G
LAIE
M
---
G
C
D
A
EDIA
L
TIHAHPTL
H
E
SVG
LAAEVFEGSITDLPNPKAKKK
fig|358709.5.peg.4906
Escherichia coli 101-1
MTAGDKYIEVMMSTEIKTQV
V
V
L
G
A
GPAGY
S
AA
F
R
C
AD
L
GL
ET
VI
V
------
ERY
N
TLGG
V
CLNVGCIPSKALLH
V
A
KV
I
E
E
AKAL
A
E
-
HG
IVFGE
P
KT
D
I
D
K
I
R
TW
K
E
K
VINQL
-
T
G
G
LA
G
MA
KG
R
K
-
VKV
V
N
GL
GK
F
T
G
A
N
----
TL
E
VE
-
G
EN
G
KT
VI
N
FDN
A
I
IA
A
GSRP
I
--
QLP
F
I
PHE
DPRIWDST
D
AL
E
L
KE
VPERLLV
M
G
G
G
I
IGLE
M
G
T
V
Y
HA
LGS
QI
D
V
VEM
F
D
QV
I
PA
A
D
KD
I
V
-K
V
FTK
R
IS
KK
FN
L
M
L
E
T
K
V
T
AVE
AK
E
---
DG
I
Y
V
T
-
ME
GKK
AP
A
E
PQ
R
Y
--
D
A
V
LVAIGRVPN
G
KN
LD
A
GKA
GVE
V
DDRG
F
I
R
VD
KQL
RTN
V
PHI
F
AIGD
I
VGQPMLAHK
G
VH
EG
H
VAAE
V
I
--
AG
K
K
H
YF
DP
---
KV
IPS
I
A
YT
E
PEVAWVG
L
TE
KE
AK
E
K
GI
S
YE
T
A
T
FP
W
A
AS
GRA
I
A
S
D
CAD
G
MT
KLIFDKES
H
RVIGGAIVG
TN
G
GEL
L
G
EI
G
LAIE
M
---
G
C
D
A
EDIA
L
TIHAHPTL
H
E
SVG
LAAEVFEGSITDLPNPKAKKK
fig|670888.3.peg.697
Escherichia coli 1827-70
MTAGDKYIEVMMSTEIKTQV
V
V
L
G
A
GPAGY
S
AA
F
R
C
AD
L
GL
ET
VI
V
------
ERY
N
TLGG
V
CLNVGCIPSKALLH
V
A
KV
I
E
E
AKAL
A
E
-
HG
IVFGE
P
KT
D
I
D
K
I
R
TW
K
E
K
VINQL
-
T
G
G
LA
G
MA
KG
R
K
-
VKV
V
N
GL
GK
F
T
G
A
N
----
TL
E
VE
-
G
EN
G
KT
VI
N
FDN
A
I
IA
A
GSRP
I
--
QLP
F
I
PHE
DPRIWDST
D
AL
E
L
KE
VPERLLV
M
G
G
G
I
IGLE
M
G
T
V
Y
HA
LGS
QI
D
V
VEM
F
D
QV
I
PA
A
D
KD
I
V
-K
V
FTK
R
IS
KK
FN
L
M
L
E
T
K
V
T
AVE
AK
E
---
DG
I
Y
V
T
-
ME
GKK
AP
A
E
PQ
R
Y
--
D
A
V
LVAIGRVPN
G
KN
LD
A
GKA
GVE
V
DDRG
F
I
R
VD
KQL
RTN
V
PHI
F
AIGD
I
VGQPMLAHK
G
VH
EG
H
VAAE
V
I
--
AG
K
K
H
YF
DP
---
KV
IPS
I
A
YT
E
PEVAWVG
L
TE
KE
AK
E
K
GI
S
YE
T
A
T
FP
W
A
AS
GRA
I
A
S
D
CAD
G
MT
KLIFDKES
H
RVIGGAIVG
TN
G
GEL
L
G
EI
G
LAIE
M
---
G
C
D
A
EDIA
L
TIHAHPTL
H
E
SVG
LAAEVFEGSITDLPNPKAKKK
fig|585055.6.peg.117
Escherichia coli 55989
MTAGDKYIEVMMSTEIKTQV
V
V
L
G
A
GPAGY
S
AA
F
R
C
AD
L
GL
ET
VI
V
------
ERY
N
TLGG
V
CLNVGCIPSKALLH
V
A
KV
I
E
E
AKAL
A
E
-
HG
IVFGE
P
KT
D
I
D
K
I
R
TW
K
E
K
VINQL
-
T
G
G
LA
G
MA
KG
R
K
-
VKV
V
N
GL
GK
F
T
G
A
N
----
TL
E
VE
-
G
EN
G
KT
VI
N
FDN
A
I
IA
A
GSRP
I
--
QLP
F
I
PHE
DPRIWDST
D
AL
E
L
KE
VPERLLV
M
G
G
G
I
IGLE
M
G
T
V
Y
HA
LGS
QI
D
V
VEM
F
D
QV
I
PA
A
D
KD
I
V
-K
V
FTK
R
IS
KK
FN
L
M
L
E
T
K
V
T
AVE
AK
E
---
DG
I
Y
V
T
-
ME
GKK
AP
A
E
PQ
R
Y
--
D
A
V
LVAIGRVPN
G
KN
LD
A
GKA
GVE
V
DDRG
F
I
R
VD
KQL
RTN
V
PHI
F
AIGD
I
VGQPMLAHK
G
VH
EG
H
VAAE
V
I
--
AG
K
K
H
YF
DP
---
KV
IPS
I
A
YT
E
PEVAWVG
L
TE
KE
AK
E
K
GI
S
YE
T
A
T
FP
W
A
AS
GRA
I
A
S
D
CAD
G
MT
KLIFDKES
H
RVIGGAIVG
TN
G
GEL
L
G
EI
G
LAIE
M
---
G
C
D
A
EDIA
L
TIHAHPTL
H
E
SVG
LAAEVFEGSITDLPNPKAKKK
fig|585055.8.peg.117
Escherichia coli 55989
MTAGDKYIEVMMSTEIKTQV
V
V
L
G
A
GPAGY
S
AA
F
R
C
AD
L
GL
ET
VI
V
------
ERY
N
TLGG
V
CLNVGCIPSKALLH
V
A
KV
I
E
E
AKAL
A
E
-
HG
IVFGE
P
KT
D
I
D
K
I
R
TW
K
E
K
VINQL
-
T
G
G
LA
G
MA
KG
R
K
-
VKV
V
N
GL
GK
F
T
G
A
N
----
TL
E
VE
-
G
EN
G
KT
VI
N
FDN
A
I
IA
A
GSRP
I
--
QLP
F
I
PHE
DPRIWDST
D
AL
E
L
KE
VPERLLV
M
G
G
G
I
IGLE
M
G
T
V
Y
HA
LGS
QI
D
V
VEM
F
D
QV
I
PA
A
D
KD
I
V
-K
V
FTK
R
IS
KK
FN
L
M
L
E
T
K
V
T
AVE
AK
E
---
DG
I
Y
V
T
-
ME
GKK
AP
A
E
PQ
R
Y
--
D
A
V
LVAIGRVPN
G
KN
LD
A
GKA
GVE
V
DDRG
F
I
R
VD
KQL
RTN
V
PHI
F
AIGD
I
VGQPMLAHK
G
VH
EG
H
VAAE
V
I
--
AG
K
K
H
YF
DP
---
KV
IPS
I
A
YT
E
PEVAWVG
L
TE
KE
AK
E
K
GI
S
YE
T
A
T
FP
W
A
AS
GRA
I
A
S
D
CAD
G
MT
KLIFDKES
H
RVIGGAIVG
TN
G
GEL
L
G
EI
G
LAIE
M
---
G
C
D
A
EDIA
L
TIHAHPTL
H
E
SVG
LAAEVFEGSITDLPNPKAKKK
fig|413997.3.peg.121
Escherichia coli B str. REL606
MTAGDKYIEVMMSTEIKTQV
V
V
L
G
A
GPAGY
S
AA
F
R
C
AD
L
GL
ET
VI
V
------
ERY
N
TLGG
V
CLNVGCIPSKALLH
V
A
KV
I
E
E
AKAL
A
E
-
HG
IVFGE
P
KT
D
I
D
K
I
R
TW
K
E
K
VINQL
-
T
G
G
LA
G
MA
KG
R
K
-
VKV
V
N
GL
GK
F
T
G
A
N
----
TL
E
VE
-
G
EN
G
KT
VI
N
FDN
A
I
IA
A
GSRP
I
--
QLP
F
I
PHE
DPRIWDST
D
AL
E
L
KE
VPERLLV
M
G
G
G
I
IGLE
M
G
T
V
Y
HA
LGS
QI
D
V
VEM
F
D
QV
I
PA
A
D
KD
I
V
-K
V
FTK
R
IS
KK
FN
L
M
L
E
T
K
V
T
AVE
AK
E
---
DG
I
Y
V
T
-
ME
GKK
AP
A
E
PQ
R
Y
--
D
A
V
LVAIGRVPN
G
KN
LD
A
GKA
GVE
V
DDRG
F
I
R
VD
KQL
RTN
V
PHI
F
AIGD
I
VGQPMLAHK
G
VH
EG
H
VAAE
V
I
--
AG
K
K
H
YF
DP
---
KV
IPS
I
A
YT
E
PEVAWVG
L
TE
KE
AK
E
K
GI
S
YE
T
A
T
FP
W
A
AS
GRA
I
A
S
D
CAD
G
MT
KLIFDKES
H
RVIGGAIVG
TN
G
GEL
L
G
EI
G
LAIE
M
---
G
C
D
A
EDIA
L
TIHAHPTL
H
E
SVG
LAAEVFEGSITDLPNPKAKKK
fig|344601.5.peg.2669
Escherichia coli B171
MTAGDKYIEVMMSTEIKTQV
V
V
L
G
A
GPAGY
S
AA
F
R
C
AD
L
GL
ET
VI
V
------
ERY
N
TLGG
V
CLNVGCIPSKALLH
V
A
KV
I
E
E
AKAL
A
E
-
HG
IVFGE
P
KT
D
I
D
K
I
R
TW
K
E
K
VINQL
-
T
G
G
LA
G
MA
KG
R
K
-
VKV
V
N
GL
GK
F
T
G
A
N
----
TL
E
VE
-
G
EN
G
KT
VI
N
FDN
A
I
IA
A
GSRP
I
--
QLP
F
I
PHE
DPRIWDST
D
AL
E
L
KE
VPERLLV
M
G
G
G
I
IGLE
M
G
T
V
Y
HA
LGS
QI
D
V
VEM
F
D
QV
I
PA
A
D
KD
I
V
-K
V
FTK
R
IS
KK
FN
L
M
L
E
T
K
V
T
AVE
AK
E
---
DG
I
Y
V
T
-
ME
GKK
AP
A
E
PQ
R
Y
--
D
A
V
LVAIGRVPN
G
KN
LD
A
GKA
GVE
V
DDRG
F
I
R
VD
KQL
RTN
V
PHI
F
AIGD
I
VGQPMLAHK
G
VH
EG
H
VAAE
V
I
--
AG
K
K
H
YF
DP
---
KV
IPS
I
A
YT
E
PEVAWVG
L
TE
KE
AK
E
K
GI
S
YE
T
A
T
FP
W
A
AS
GRA
I
A
S
D
CAD
G
MT
KLIFDKES
H
RVIGGAIVG
TN
G
GEL
L
G
EI
G
LAIE
M
---
G
C
D
A
EDIA
L
TIHAHPTL
H
E
SVG
LAAEVFEGSITDLPNPKAKKK
fig|550677.3.peg.504
Escherichia coli B354
MTAGDKYIEVMMSTEIKTQV
V
V
L
G
A
GPAGY
S
AA
F
R
C
AD
L
GL
ET
VI
V
------
ERY
N
TLGG
V
CLNVGCIPSKALLH
V
A
KV
I
E
E
AKAL
A
E
-
HG
IVFGE
P
KT
D
I
D
K
I
R
TW
K
E
K
VINQL
-
T
G
G
LA
G
MA
KG
R
K
-
VKV
V
N
GL
GK
F
T
G
A
N
----
TL
E
VE
-
G
EN
G
KT
VI
N
FDN
A
I
IA
A
GSRP
I
--
QLP
F
I
PHE
DPRIWDST
D
AL
E
L
KE
VPERLLV
M
G
G
G
I
IGLE
M
G
T
V
Y
HA
LGS
QI
D
V
VEM
F
D
QV
I
PA
A
D
KD
I
V
-K
V
FTK
R
IS
KK
FN
L
M
L
E
T
K
V
T
AVE
AK
E
---
DG
I
Y
V
T
-
ME
GKK
AP
A
E
PQ
R
Y
--
D
A
V
LVAIGRVPN
G
KN
LD
A
GKA
GVE
V
DDRG
F
I
R
VD
KQL
RTN
V
PHI
F
AIGD
I
VGQPMLAHK
G
VH
EG
H
VAAE
V
I
--
AG
K
K
H
YF
DP
---
KV
IPS
I
A
YT
E
PEVAWVG
L
TE
KE
AK
E
K
GI
S
YE
T
A
T
FP
W
A
AS
GRA
I
A
S
D
CAD
G
MT
KLIFDKES
H
RVIGGAIVG
TN
G
GEL
L
G
EI
G
LAIE
M
---
G
C
D
A
EDIA
L
TIHAHPTL
H
E
SVG
LAAEVFEGSITDLPNPKAKKK
fig|340184.6.peg.1519
Escherichia coli B7A
MTAGDKYIEVMMSTEIKTQV
V
V
L
G
A
GPAGY
S
AA
F
R
C
AD
L
GL
ET
VI
V
------
ERY
N
TLGG
V
CLNVGCIPSKALLH
V
A
KV
I
E
E
AKAL
A
E
-
HG
IVFGE
P
KT
D
I
D
K
I
R
TW
K
E
K
VINQL
-
T
G
G
LA
G
MA
KG
R
K
-
VKV
V
N
GL
GK
F
T
G
A
N
----
TL
E
VE
-
G
EN
G
KT
VI
N
FDN
A
I
IA
A
GSRP
I
--
QLP
F
I
PHE
DPRIWDST
D
AL
E
L
KE
VPERLLV
M
G
G
G
I
IGLE
M
G
T
V
Y
HA
LGS
QI
D
V
VEM
F
D
QV
I
PA
A
D
KD
I
V
-K
V
FTK
R
IS
KK
FN
L
M
L
E
T
K
V
T
AVE
AK
E
---
DG
I
Y
V
T
-
ME
GKK
AP
A
E
PQ
R
Y
--
D
A
V
LVAIGRVPN
G
KN
LD
A
GKA
GVE
V
DDRG
F
I
R
VD
KQL
RTN
V
PHI
F
AIGD
I
VGQPMLAHK
G
VH
EG
H
VAAE
V
I
--
AG
K
K
H
YF
DP
---
KV
IPS
I
A
YT
E
PEVAWVG
L
TE
KE
AK
E
K
GI
S
YE
T
A
T
FP
W
A
AS
GRA
I
A
S
D
CAD
G
MT
KLIFDKES
H
RVIGGAIVG
TN
G
GEL
L
G
EI
G
LAIE
M
---
G
C
D
A
EDIA
L
TIHAHPTL
H
E
SVG
LAAEVFEGSITDLPNPKAKKK
fig|469008.4.peg.3623
Escherichia coli BL21(DE3)
MTAGDKYIEVMMSTEIKTQV
V
V
L
G
A
GPAGY
S
AA
F
R
C
AD
L
GL
ET
VI
V
------
ERY
N
TLGG
V
CLNVGCIPSKALLH
V
A
KV
I
E
E
AKAL
A
E
-
HG
IVFGE
P
KT
D
I
D
K
I
R
TW
K
E
K
VINQL
-
T
G
G
LA
G
MA
KG
R
K
-
VKV
V
N
GL
GK
F
T
G
A
N
----
TL
E
VE
-
G
EN
G
KT
VI
N
FDN
A
I
IA
A
GSRP
I
--
QLP
F
I
PHE
DPRIWDST
D
AL
E
L
KE
VPERLLV
M
G
G
G
I
IGLE
M
G
T
V
Y
HA
LGS
QI
D
V
VEM
F
D
QV
I
PA
A
D
KD
I
V
-K
V
FTK
R
IS
KK
FN
L
M
L
E
T
K
V
T
AVE
AK
E
---
DG
I
Y
V
T
-
ME
GKK
AP
A
E
PQ
R
Y
--
D
A
V
LVAIGRVPN
G
KN
LD
A
GKA
GVE
V
DDRG
F
I
R
VD
KQL
RTN
V
PHI
F
AIGD
I
VGQPMLAHK
G
VH
EG
H
VAAE
V
I
--
AG
K
K
H
YF
DP
---
KV
IPS
I
A
YT
E
PEVAWVG
L
TE
KE
AK
E
K
GI
S
YE
T
A
T
FP
W
A
AS
GRA
I
A
S
D
CAD
G
MT
KLIFDKES
H
RVIGGAIVG
TN
G
GEL
L
G
EI
G
LAIE
M
---
G
C
D
A
EDIA
L
TIHAHPTL
H
E
SVG
LAAEVFEGSITDLPNPKAKKK
fig|595496.3.peg.119
Escherichia coli BW2952
MTAGDKYIEVMMSTEIKTQV
V
V
L
G
A
GPAGY
S
AA
F
R
C
AD
L
GL
ET
VI
V
------
ERY
N
TLGG
V
CLNVGCIPSKALLH
V
A
KV
I
E
E
AKAL
A
E
-
HG
IVFGE
P
KT
D
I
D
K
I
R
TW
K
E
K
VINQL
-
T
G
G
LA
G
MA
KG
R
K
-
VKV
V
N
GL
GK
F
T
G
A
N
----
TL
E
VE
-
G
EN
G
KT
VI
N
FDN
A
I
IA
A
GSRP
I
--
QLP
F
I
PHE
DPRIWDST
D
AL
E
L
KE
VPERLLV
M
G
G
G
I
IGLE
M
G
T
V
Y
HA
LGS
QI
D
V
VEM
F
D
QV
I
PA
A
D
KD
I
V
-K
V
FTK
R
IS
KK
FN
L
M
L
E
T
K
V
T
AVE
AK
E
---
DG
I
Y
V
T
-
ME
GKK
AP
A
E
PQ
R
Y
--
D
A
V
LVAIGRVPN
G
KN
LD
A
GKA
GVE
V
DDRG
F
I
R
VD
KQL
RTN
V
PHI
F
AIGD
I
VGQPMLAHK
G
VH
EG
H
VAAE
V
I
--
AG
K
K
H
YF
DP
---
KV
IPS
I
A
YT
E
PEVAWVG
L
TE
KE
AK
E
K
GI
S
YE
T
A
T
FP
W
A
AS
GRA
I
A
S
D
CAD
G
MT
KLIFDKES
H
RVIGGAIVG
TN
G
GEL
L
G
EI
G
LAIE
M
---
G
C
D
A
EDIA
L
TIHAHPTL
H
E
SVG
LAAEVFEGSITDLPNPKAKKK
fig|536056.3.peg.3684
Escherichia coli DH1
MTAGDKYIEVMMSTEIKTQV
V
V
L
G
A
GPAGY
S
AA
F
R
C
AD
L
GL
ET
VI
V
------
ERY
N
TLGG
V
CLNVGCIPSKALLH
V
A
KV
I
E
E
AKAL
A
E
-
HG
IVFGE
P
KT
D
I
D
K
I
R
TW
K
E
K
VINQL
-
T
G
G
LA
G
MA
KG
R
K
-
VKV
V
N
GL
GK
F
T
G
A
N
----
TL
E
VE
-
G
EN
G
KT
VI
N
FDN
A
I
IA
A
GSRP
I
--
QLP
F
I
PHE
DPRIWDST
D
AL
E
L
KE
VPERLLV
M
G
G
G
I
IGLE
M
G
T
V
Y
HA
LGS
QI
D
V
VEM
F
D
QV
I
PA
A
D
KD
I
V
-K
V
FTK
R
IS
KK
FN
L
M
L
E
T
K
V
T
AVE
AK
E
---
DG
I
Y
V
T
-
ME
GKK
AP
A
E
PQ
R
Y
--
D
A
V
LVAIGRVPN
G
KN
LD
A
GKA
GVE
V
DDRG
F
I
R
VD
KQL
RTN
V
PHI
F
AIGD
I
VGQPMLAHK
G
VH
EG
H
VAAE
V
I
--
AG
K
K
H
YF
DP
---
KV
IPS
I
A
YT
E
PEVAWVG
L
TE
KE
AK
E
K
GI
S
YE
T
A
T
FP
W
A
AS
GRA
I
A
S
D
CAD
G
MT
KLIFDKES
H
RVIGGAIVG
TN
G
GEL
L
G
EI
G
LAIE
M
---
G
C
D
A
EDIA
L
TIHAHPTL
H
E
SVG
LAAEVFEGSITDLPNPKAKKK
fig|340186.5.peg.4687
Escherichia coli E110019
MTAGDKYIEVMMSTEIKTQV
V
V
L
G
A
GPAGY
S
AA
F
R
C
AD
L
GL
ET
VI
V
------
ERY
N
TLGG
V
CLNVGCIPSKALLH
V
A
KV
I
E
E
AKAL
A
E
-
HG
IVFGE
P
KT
D
I
D
K
I
R
TW
K
E
K
VINQL
-
T
G
G
LA
G
MA
KG
R
K
-
VKV
V
N
GL
GK
F
T
G
A
N
----
TL
E
VE
-
G
EN
G
KT
VI
N
FDN
A
I
IA
A
GSRP
I
--
QLP
F
I
PHE
DPRIWDST
D
AL
E
L
KE
VPERLLV
M
G
G
G
I
IGLE
M
G
T
V
Y
HA
LGS
QI
D
V
VEM
F
D
QV
I
PA
A
D
KD
I
V
-K
V
FTK
R
IS
KK
FN
L
M
L
E
T
K
V
T
AVE
AK
E
---
DG
I
Y
V
T
-
ME
GKK
AP
A
E
PQ
R
Y
--
D
A
V
LVAIGRVPN
G
KN
LD
A
GKA
GVE
V
DDRG
F
I
R
VD
KQL
RTN
V
PHI
F
AIGD
I
VGQPMLAHK
G
VH
EG
H
VAAE
V
I
--
AG
K
K
H
YF
DP
---
KV
IPS
I
A
YT
E
PEVAWVG
L
TE
KE
AK
E
K
GI
S
YE
T
A
T
FP
W
A
AS
GRA
I
A
S
D
CAD
G
MT
KLIFDKES
H
RVIGGAIVG
TN
G
GEL
L
G
EI
G
LAIE
M
---
G
C
D
A
EDIA
L
TIHAHPTL
H
E
SVG
LAAEVFEGSITDLPNPKAKKK
fig|340185.4.peg.1731
Escherichia coli E22
MTAGDKYIEVMMSTEIKTQV
V
V
L
G
A
GPAGY
S
AA
F
R
C
AD
L
GL
ET
VI
V
------
ERY
N
TLGG
V
CLNVGCIPSKALLH
V
A
KV
I
E
E
AKAL
A
E
-
HG
IVFGE
P
KT
D
I
D
K
I
R
TW
K
E
K
VINQL
-
T
G
G
LA
G
MA
KG
R
K
-
VKV
V
N
GL
GK
F
T
G
A
N
----
TL
E
VE
-
G
EN
G
KT
VI
N
FDN
A
I
IA
A
GSRP
I
--
QLP
F
I
PHE
DPRIWDST
D
AL
E
L
KE
VPERLLV
M
G
G
G
I
IGLE
M
G
T
V
Y
HA
LGS
QI
D
V
VEM
F
D
QV
I
PA
A
D
KD
I
V
-K
V
FTK
R
IS
KK
FN
L
M
L
E
T
K
V
T
AVE
AK
E
---
DG
I
Y
V
T
-
ME
GKK
AP
A
E
PQ
R
Y
--
D
A
V
LVAIGRVPN
G
KN
LD
A
GKA
GVE
V
DDRG
F
I
R
VD
KQL
RTN
V
PHI
F
AIGD
I
VGQPMLAHK
G
VH
EG
H
VAAE
V
I
--
AG
K
K
H
YF
DP
---
KV
IPS
I
A
YT
E
PEVAWVG
L
TE
KE
AK
E
K
GI
S
YE
T
A
T
FP
W
A
AS
GRA
I
A
S
D
CAD
G
MT
KLIFDKES
H
RVIGGAIVG
TN
G
GEL
L
G
EI
G
LAIE
M
---
G
C
D
A
EDIA
L
TIHAHPTL
H
E
SVG
LAAEVFEGSITDLPNPKAKKK
fig|331111.12.peg.448
Escherichia coli E24377A
MTAGDKYIEVMMSTEIKTQV
V
V
L
G
A
GPAGY
S
AA
F
R
C
AD
L
GL
ET
VI
V
------
ERY
N
TLGG
V
CLNVGCIPSKALLH
V
A
KV
I
E
E
AKAL
A
E
-
HG
IVFGE
P
KT
D
I
D
K
I
R
TW
K
E
K
VINQL
-
T
G
G
LA
G
MA
KG
R
K
-
VKV
V
N
GL
GK
F
T
G
A
N
----
TL
E
VE
-
G
EN
G
KT
VI
N
FDN
A
I
IA
A
GSRP
I
--
QLP
F
I
PHE
DPRIWDST
D
AL
E
L
KE
VPERLLV
M
G
G
G
I
IGLE
M
G
T
V
Y
HA
LGS
QI
D
V
VEM
F
D
QV
I
PA
A
D
KD
I
V
-K
V
FTK
R
IS
KK
FN
L
M
L
E
T
K
V
T
AVE
AK
E
---
DG
I
Y
V
T
-
ME
GKK
AP
A
E
PQ
R
Y
--
D
A
V
LVAIGRVPN
G
KN
LD
A
GKA
GVE
V
DDRG
F
I
R
VD
KQL
RTN
V
PHI
F
AIGD
I
VGQPMLAHK
G
VH
EG
H
VAAE
V
I
--
AG
K
K
H
YF
DP
---
KV
IPS
I
A
YT
E
PEVAWVG
L
TE
KE
AK
E
K
GI
S
YE
T
A
T
FP
W
A
AS
GRA
I
A
S
D
CAD
G
MT
KLIFDKES
H
RVIGGAIVG
TN
G
GEL
L
G
EI
G
LAIE
M
---
G
C
D
A
EDIA
L
TIHAHPTL
H
E
SVG
LAAEVFEGSITDLPNPKAKKK
fig|562.375.peg.2532
Escherichia coli EC4100B
MTAGDKYIEVMMSTEIKTQV
V
V
L
G
A
GPAGY
S
AA
F
R
C
AD
L
GL
ET
VI
V
------
ERY
N
TLGG
V
CLNVGCIPSKALLH
V
A
KV
I
E
E
AKAL
A
E
-
HG
IVFGE
P
KT
D
I
D
K
I
R
TW
K
E
K
VINQL
-
T
G
G
LA
G
MA
KG
R
K
-
VKV
V
N
GL
GK
F
T
G
A
N
----
TL
E
VE
-
G
EN
G
KT
VI
N
FDN
A
I
IA
A
GSRP
I
--
QLP
F
I
PHE
DPRIWDST
D
AL
E
L
KE
VPERLLV
M
G
G
G
I
IGLE
M
G
T
V
Y
HA
LGS
QI
D
V
VEM
F
D
QV
I
PA
A
D
KD
I
V
-K
V
FTK
R
IS
KK
FN
L
M
L
E
T
K
V
T
AVE
AK
E
---
DG
I
Y
V
T
-
ME
GKK
AP
A
E
PQ
R
Y
--
D
A
V
LVAIGRVPN
G
KN
LD
A
GKA
GVE
V
DDRG
F
I
R
VD
KQL
RTN
V
PHI
F
AIGD
I
VGQPMLAHK
G
VH
EG
H
VAAE
V
I
--
AG
K
K
H
YF
DP
---
KV
IPS
I
A
YT
E
PEVAWVG
L
TE
KE
AK
E
K
GI
S
YE
T
A
T
FP
W
A
AS
GRA
I
A
S
D
CAD
G
MT
KLIFDKES
H
RVIGGAIVG
TN
G
GEL
L
G
EI
G
LAIE
M
---
G
C
D
A
EDIA
L
TIHAHPTL
H
E
SVG
LAAEVFEGSITDLPNPKAKKK
fig|316401.4.peg.127
Escherichia coli ETEC H10407
MTAGDKYIEVMMSTEIKTQV
V
V
L
G
A
GPAGY
S
AA
F
R
C
AD
L
GL
ET
VI
V
------
ERY
N
TLGG
V
CLNVGCIPSKALLH
V
A
KV
I
E
E
AKAL
A
E
-
HG
IVFGE
P
KT
D
I
D
K
I
R
TW
K
E
K
VINQL
-
T
G
G
LA
G
MA
KG
R
K
-
VKV
V
N
GL
GK
F
T
G
A
N
----
TL
E
VE
-
G
EN
G
KT
VI
N
FDN
A
I
IA
A
GSRP
I
--
QLP
F
I
PHE
DPRIWDST
D
AL
E
L
KE
VPERLLV
M
G
G
G
I
IGLE
M
G
T
V
Y
HA
LGS
QI
D
V
VEM
F
D
QV
I
PA
A
D
KD
I
V
-K
V
FTK
R
IS
KK
FN
L
M
L
E
T
K
V
T
AVE
AK
E
---
DG
I
Y
V
T
-
ME
GKK
AP
A
E
PQ
R
Y
--
D
A
V
LVAIGRVPN
G
KN
LD
A
GKA
GVE
V
DDRG
F
I
R
VD
KQL
RTN
V
PHI
F
AIGD
I
VGQPMLAHK
G
VH
EG
H
VAAE
V
I
--
AG
K
K
H
YF
DP
---
KV
IPS
I
A
YT
E
PEVAWVG
L
TE
KE
AK
E
K
GI
S
YE
T
A
T
FP
W
A
AS
GRA
I
A
S
D
CAD
G
MT
KLIFDKES
H
RVIGGAIVG
TN
G
GEL
L
G
EI
G
LAIE
M
---
G
C
D
A
EDIA
L
TIHAHPTL
H
E
SVG
LAAEVFEGSITDLPNPKAKKK
fig|656408.3.peg.5072
Escherichia coli H591
MTAGDKYIEVMMSTEIKTQV
V
V
L
G
A
GPAGY
S
AA
F
R
C
AD
L
GL
ET
VI
V
------
ERY
N
TLGG
V
CLNVGCIPSKALLH
V
A
KV
I
E
E
AKAL
A
E
-
HG
IVFGE
P
KT
D
I
D
K
I
R
TW
K
E
K
VINQL
-
T
G
G
LA
G
MA
KG
R
K
-
VKV
V
N
GL
GK
F
T
G
A
N
----
TL
E
VE
-
G
EN
G
KT
VI
N
FDN
A
I
IA
A
GSRP
I
--
QLP
F
I
PHE
DPRIWDST
D
AL
E
L
KE
VPERLLV
M
G
G
G
I
IGLE
M
G
T
V
Y
HA
LGS
QI
D
V
VEM
F
D
QV
I
PA
A
D
KD
I
V
-K
V
FTK
R
IS
KK
FN
L
M
L
E
T
K
V
T
AVE
AK
E
---
DG
I
Y
V
T
-
ME
GKK
AP
A
E
PQ
R
Y
--
D
A
V
LVAIGRVPN
G
KN
LD
A
GKA
GVE
V
DDRG
F
I
R
VD
KQL
RTN
V
PHI
F
AIGD
I
VGQPMLAHK
G
VH
EG
H
VAAE
V
I
--
AG
K
K
H
YF
DP
---
KV
IPS
I
A
YT
E
PEVAWVG
L
TE
KE
AK
E
K
GI
S
YE
T
A
T
FP
W
A
AS
GRA
I
A
S
D
CAD
G
MT
KLIFDKES
H
RVIGGAIVG
TN
G
GEL
L
G
EI
G
LAIE
M
---
G
C
D
A
EDIA
L
TIHAHPTL
H
E
SVG
LAAEVFEGSITDLPNPKAKKK
fig|656414.3.peg.239
Escherichia coli H736
MTAGDKYIEVMMSTEIKTQV
V
V
L
G
A
GPAGY
S
AA
F
R
C
AD
L
GL
ET
VI
V
------
ERY
N
TLGG
V
CLNVGCIPSKALLH
V
A
KV
I
E
E
AKAL
A
E
-
HG
IVFGE
P
KT
D
I
D
K
I
R
TW
K
E
K
VINQL
-
T
G
G
LA
G
MA
KG
R
K
-
VKV
V
N
GL
GK
F
T
G
A
N
----
TL
E
VE
-
G
EN
G
KT
VI
N
FDN
A
I
IA
A
GSRP
I
--
QLP
F
I
PHE
DPRIWDST
D
AL
E
L
KE
VPERLLV
M
G
G
G
I
IGLE
M
G
T
V
Y
HA
LGS
QI
D
V
VEM
F
D
QV
I
PA
A
D
KD
I
V
-K
V
FTK
R
IS
KK
FN
L
M
L
E
T
K
V
T
AVE
AK
E
---
DG
I
Y
V
T
-
ME
GKK
AP
A
E
PQ
R
Y
--
D
A
V
LVAIGRVPN
G
KN
LD
A
GKA
GVE
V
DDRG
F
I
R
VD
KQL
RTN
V
PHI
F
AIGD
I
VGQPMLAHK
G
VH
EG
H
VAAE
V
I
--
AG
K
K
H
YF
DP
---
KV
IPS
I
A
YT
E
PEVAWVG
L
TE
KE
AK
E
K
GI
S
YE
T
A
T
FP
W
A
AS
GRA
I
A
S
D
CAD
G
MT
KLIFDKES
H
RVIGGAIVG
TN
G
GEL
L
G
EI
G
LAIE
M
---
G
C
D
A
EDIA
L
TIHAHPTL
H
E
SVG
LAAEVFEGSITDLPNPKAKKK
fig|331112.6.peg.120
Escherichia coli HS
MTAGDKYIEVMMSTEIKTQV
V
V
L
G
A
GPAGY
S
AA
F
R
C
AD
L
GL
ET
VI
V
------
ERY
N
TLGG
V
CLNVGCIPSKALLH
V
A
KV
I
E
E
AKAL
A
E
-
HG
IVFGE
P
KT
D
I
D
K
I
R
TW
K
E
K
VINQL
-
T
G
G
LA
G
MA
KG
R
K
-
VKV
V
N
GL
GK
F
T
G
A
N
----
TL
E
VE
-
G
EN
G
KT
VI
N
FDN
A
I
IA
A
GSRP
I
--
QLP
F
I
PHE
DPRIWDST
D
AL
E
L
KE
VPERLLV
M
G
G
G
I
IGLE
M
G
T
V
Y
HA
LGS
QI
D
V
VEM
F
D
QV
I
PA
A
D
KD
I
V
-K
V
FTK
R
IS
KK
FN
L
M
L
E
T
K
V
T
AVE
AK
E
---
DG
I
Y
V
T
-
ME
GKK
AP
A
E
PQ
R
Y
--
D
A
V
LVAIGRVPN
G
KN
LD
A
GKA
GVE
V
DDRG
F
I
R
VD
KQL
RTN
V
PHI
F
AIGD
I
VGQPMLAHK
G
VH
EG
H
VAAE
V
I
--
AG
K
K
H
YF
DP
---
KV
IPS
I
A
YT
E
PEVAWVG
L
TE
KE
AK
E
K
GI
S
YE
T
A
T
FP
W
A
AS
GRA
I
A
S
D
CAD
G
MT
KLIFDKES
H
RVIGGAIVG
TN
G
GEL
L
G
EI
G
LAIE
M
---
G
C
D
A
EDIA
L
TIHAHPTL
H
E
SVG
LAAEVFEGSITDLPNPKAKKK
fig|585034.4.peg.116
Escherichia coli IAI1
MTAGDKYIEVMMSTEIKTQV
V
V
L
G
A
GPAGY
S
AA
F
R
C
AD
L
GL
ET
VI
V
------
ERY
N
TLGG
V
CLNVGCIPSKALLH
V
A
KV
I
E
E
AKAL
A
E
-
HG
IVFGE
P
KT
D
I
D
K
I
R
TW
K
E
K
VINQL
-
T
G
G
LA
G
MA
KG
R
K
-
VKV
V
N
GL
GK
F
T
G
A
N
----
TL
E
VE
-
G
EN
G
KT
VI
N
FDN
A
I
IA
A
GSRP
I
--
QLP
F
I
PHE
DPRIWDST
D
AL
E
L
KE
VPERLLV
M
G
G
G
I
IGLE
M
G
T
V
Y
HA
LGS
QI
D
V
VEM
F
D
QV
I
PA
A
D
KD
I
V
-K
V
FTK
R
IS
KK
FN
L
M
L
E
T
K
V
T
AVE
AK
E
---
DG
I
Y
V
T
-
ME
GKK
AP
A
E
PQ
R
Y
--
D
A
V
LVAIGRVPN
G
KN
LD
A
GKA
GVE
V
DDRG
F
I
R
VD
KQL
RTN
V
PHI
F
AIGD
I
VGQPMLAHK
G
VH
EG
H
VAAE
V
I
--
AG
K
K
H
YF
DP
---
KV
IPS
I
A
YT
E
PEVAWVG
L
TE
KE
AK
E
K
GI
S
YE
T
A
T
FP
W
A
AS
GRA
I
A
S
D
CAD
G
MT
KLIFDKES
H
RVIGGAIVG
TN
G
GEL
L
G
EI
G
LAIE
M
---
G
C
D
A
EDIA
L
TIHAHPTL
H
E
SVG
LAAEVFEGSITDLPNPKAKKK
fig|585034.5.peg.116
Escherichia coli IAI1
MTAGDKYIEVMMSTEIKTQV
V
V
L
G
A
GPAGY
S
AA
F
R
C
AD
L
GL
ET
VI
V
------
ERY
N
TLGG
V
CLNVGCIPSKALLH
V
A
KV
I
E
E
AKAL
A
E
-
HG
IVFGE
P
KT
D
I
D
K
I
R
TW
K
E
K
VINQL
-
T
G
G
LA
G
MA
KG
R
K
-
VKV
V
N
GL
GK
F
T
G
A
N
----
TL
E
VE
-
G
EN
G
KT
VI
N
FDN
A
I
IA
A
GSRP
I
--
QLP
F
I
PHE
DPRIWDST
D
AL
E
L
KE
VPERLLV
M
G
G
G
I
IGLE
M
G
T
V
Y
HA
LGS
QI
D
V
VEM
F
D
QV
I
PA
A
D
KD
I
V
-K
V
FTK
R
IS
KK
FN
L
M
L
E
T
K
V
T
AVE
AK
E
---
DG
I
Y
V
T
-
ME
GKK
AP
A
E
PQ
R
Y
--
D
A
V
LVAIGRVPN
G
KN
LD
A
GKA
GVE
V
DDRG
F
I
R
VD
KQL
RTN
V
PHI
F
AIGD
I
VGQPMLAHK
G
VH
EG
H
VAAE
V
I
--
AG
K
K
H
YF
DP
---
KV
IPS
I
A
YT
E
PEVAWVG
L
TE
KE
AK
E
K
GI
S
YE
T
A
T
FP
W
A
AS
GRA
I
A
S
D
CAD
G
MT
KLIFDKES
H
RVIGGAIVG
TN
G
GEL
L
G
EI
G
LAIE
M
---
G
C
D
A
EDIA
L
TIHAHPTL
H
E
SVG
LAAEVFEGSITDLPNPKAKKK
fig|595495.4.peg.1603
Escherichia coli KO11
MTAGDKYIEVMMSTEIKTQV
V
V
L
G
A
GPAGY
S
AA
F
R
C
AD
L
GL
ET
VI
V
------
ERY
N
TLGG
V
CLNVGCIPSKALLH
V
A
KV
I
E
E
AKAL
A
E
-
HG
IVFGE
P
KT
D
I
D
K
I
R
TW
K
E
K
VINQL
-
T
G
G
LA
G
MA
KG
R
K
-
VKV
V
N
GL
GK
F
T
G
A
N
----
TL
E
VE
-
G
EN
G
KT
VI
N
FDN
A
I
IA
A
GSRP
I
--
QLP
F
I
PHE
DPRIWDST
D
AL
E
L
KE
VPERLLV
M
G
G
G
I
IGLE
M
G
T
V
Y
HA
LGS
QI
D
V
VEM
F
D
QV
I
PA
A
D
KD
I
V
-K
V
FTK
R
IS
KK
FN
L
M
L
E
T
K
V
T
AVE
AK
E
---
DG
I
Y
V
T
-
ME
GKK
AP
A
E
PQ
R
Y
--
D
A
V
LVAIGRVPN
G
KN
LD
A
GKA
GVE
V
DDRG
F
I
R
VD
KQL
RTN
V
PHI
F
AIGD
I
VGQPMLAHK
G
VH
EG
H
VAAE
V
I
--
AG
K
K
H
YF
DP
---
KV
IPS
I
A
YT
E
PEVAWVG
L
TE
KE
AK
E
K
GI
S
YE
T
A
T
FP
W
A
AS
GRA
I
A
S
D
CAD
G
MT
KLIFDKES
H
RVIGGAIVG
TN
G
GEL
L
G
EI
G
LAIE
M
---
G
C
D
A
EDIA
L
TIHAHPTL
H
E
SVG
LAAEVFEGSITDLPNPKAKKK
fig|679207.4.peg.1160
Escherichia coli MS 107-1
MTAGDKYIEVMMSTEIKTQV
V
V
L
G
A
GPAGY
S
AA
F
R
C
AD
L
GL
ET
VI
V
------
ERY
N
TLGG
V
CLNVGCIPSKALLH
V
A
KV
I
E
E
AKAL
A
E
-
HG
IVFGE
P
KT
D
I
D
K
I
R
TW
K
E
K
VINQL
-
T
G
G
LA
G
MA
KG
R
K
-
VKV
V
N
GL
GK
F
T
G
A
N
----
TL
E
VE
-
G
EN
G
KT
VI
N
FDN
A
I
IA
A
GSRP
I
--
QLP
F
I
PHE
DPRIWDST
D
AL
E
L
KE
VPERLLV
M
G
G
G
I
IGLE
M
G
T
V
Y
HA
LGS
QI
D
V
VEM
F
D
QV
I
PA
A
D
KD
I
V
-K
V
FTK
R
IS
KK
FN
L
M
L
E
T
K
V
T
AVE
AK
E
---
DG
I
Y
V
T
-
ME
GKK
AP
A
E
PQ
R
Y
--
D
A
V
LVAIGRVPN
G
KN
LD
A
GKA
GVE
V
DDRG
F
I
R
VD
KQL
RTN
V
PHI
F
AIGD
I
VGQPMLAHK
G
VH
EG
H
VAAE
V
I
--
AG
K
K
H
YF
DP
---
KV
IPS
I
A
YT
E
PEVAWVG
L
TE
KE
AK
E
K
GI
S
YE
T
A
T
FP
W
A
AS
GRA
I
A
S
D
CAD
G
MT
KLIFDKES
H
RVIGGAIVG
TN
G
GEL
L
G
EI
G
LAIE
M
---
G
C
D
A
EDIA
L
TIHAHPTL
H
E
SVG
LAAEVFEGSITDLPNPKAKKK
fig|749538.3.peg.3146
Escherichia coli MS 116-1
MTAGDKYIEVMMSTEIKTQV
V
V
L
G
A
GPAGY
S
AA
F
R
C
AD
L
GL
ET
VI
V
------
ERY
N
TLGG
V
CLNVGCIPSKALLH
V
A
KV
I
E
E
AKAL
A
E
-
HG
IVFGE
P
KT
D
I
D
K
I
R
TW
K
E
K
VINQL
-
T
G
G
LA
G
MA
KG
R
K
-
VKV
V
N
GL
GK
F
T
G
A
N
----
TL
E
VE
-
G
EN
G
KT
VI
N
FDN
A
I
IA
A
GSRP
I
--
QLP
F
I
PHE
DPRIWDST
D
AL
E
L
KE
VPERLLV
M
G
G
G
I
IGLE
M
G
T
V
Y
HA
LGS
QI
D
V
VEM
F
D
QV
I
PA
A
D
KD
I
V
-K
V
FTK
R
IS
KK
FN
L
M
L
E
T
K
V
T
AVE
AK
E
---
DG
I
Y
V
T
-
ME
GKK
AP
A
E
PQ
R
Y
--
D
A
V
LVAIGRVPN
G
KN
LD
A
GKA
GVE
V
DDRG
F
I
R
VD
KQL
RTN
V
PHI
F
AIGD
I
VGQPMLAHK
G
VH
EG
H
VAAE
V
I
--
AG
K
K
H
YF
DP
---
KV
IPS
I
A
YT
E
PEVAWVG
L
TE
KE
AK
E
K
GI
S
YE
T
A
T
FP
W
A
AS
GRA
I
A
S
D
CAD
G
MT
KLIFDKES
H
RVIGGAIVG
TN
G
GEL
L
G
EI
G
LAIE
M
---
G
C
D
A
EDIA
L
TIHAHPTL
H
E
SVG
LAAEVFEGSITDLPNPKAKKK
fig|679206.4.peg.1649
Escherichia coli MS 119-7
MTAGDKYIEVMMSTEIKTQV
V
V
L
G
A
GPAGY
S
AA
F
R
C
AD
L
GL
ET
VI
V
------
ERY
N
TLGG
V
CLNVGCIPSKALLH
V
A
KV
I
E
E
AKAL
A
E
-
HG
IVFGE
P
KT
D
I
D
K
I
R
TW
K
E
K
VINQL
-
T
G
G
LA
G
MA
KG
R
K
-
VKV
V
N
GL
GK
F
T
G
A
N
----
TL
E
VE
-
G
EN
G
KT
VI
N
FDN
A
I
IA
A
GSRP
I
--
QLP
F
I
PHE
DPRIWDST
D
AL
E
L
KE
VPERLLV
M
G
G
G
I
IGLE
M
G
T
V
Y
HA
LGS
QI
D
V
VEM
F
D
QV
I
PA
A
D
KD
I
V
-K
V
FTK
R
IS
KK
FN
L
M
L
E
T
K
V
T
AVE
AK
E
---
DG
I
Y
V
T
-
ME
GKK
AP
A
E
PQ
R
Y
--
D
A
V
LVAIGRVPN
G
KN
LD
A
GKA
GVE
V
DDRG
F
I
R
VD
KQL
RTN
V
PHI
F
AIGD
I
VGQPMLAHK
G
VH
EG
H
VAAE
V
I
--
AG
K
K
H
YF
DP
---
KV
IPS
I
A
YT
E
PEVAWVG
L
TE
KE
AK
E
K
GI
S
YE
T
A
T
FP
W
A
AS
GRA
I
A
S
D
CAD
G
MT
KLIFDKES
H
RVIGGAIVG
TN
G
GEL
L
G
EI
G
LAIE
M
---
G
C
D
A
EDIA
L
TIHAHPTL
H
E
SVG
LAAEVFEGSITDLPNPKAKKK
fig|679204.3.peg.3237
Escherichia coli MS 145-7
MTAGDKYIEVMMSTEIKTQV
V
V
L
G
A
GPAGY
S
AA
F
R
C
AD
L
GL
ET
VI
V
------
ERY
N
TLGG
V
CLNVGCIPSKALLH
V
A
KV
I
E
E
AKAL
A
E
-
HG
IVFGE
P
KT
D
I
D
K
I
R
TW
K
E
K
VINQL
-
T
G
G
LA
G
MA
KG
R
K
-
VKV
V
N
GL
GK
F
T
G
A
N
----
TL
E
VE
-
G
EN
G
KT
VI
N
FDN
A
I
IA
A
GSRP
I
--
QLP
F
I
PHE
DPRIWDST
D
AL
E
L
KE
VPERLLV
M
G
G
G
I
IGLE
M
G
T
V
Y
HA
LGS
QI
D
V
VEM
F
D
QV
I
PA
A
D
KD
I
V
-K
V
FTK
R
IS
KK
FN
L
M
L
E
T
K
V
T
AVE
AK
E
---
DG
I
Y
V
T
-
ME
GKK
AP
A
E
PQ
R
Y
--
D
A
V
LVAIGRVPN
G
KN
LD
A
GKA
GVE
V
DDRG
F
I
R
VD
KQL
RTN
V
PHI
F
AIGD
I
VGQPMLAHK
G
VH
EG
H
VAAE
V
I
--
AG
K
K
H
YF
DP
---
KV
IPS
I
A
YT
E
PEVAWVG
L
TE
KE
AK
E
K
GI
S
YE
T
A
T
FP
W
A
AS
GRA
I
A
S
D
CAD
G
MT
KLIFDKES
H
RVIGGAIVG
TN
G
GEL
L
G
EI
G
LAIE
M
---
G
C
D
A
EDIA
L
TIHAHPTL
H
E
SVG
LAAEVFEGSITDLPNPKAKKK
fig|749540.3.peg.2895
Escherichia coli MS 146-1
MTAGDKYIEVMMSTEIKTQV
V
V
L
G
A
GPAGY
S
AA
F
R
C
AD
L
GL
ET
VI
V
------
ERY
N
TLGG
V
CLNVGCIPSKALLH
V
A
KV
I
E
E
AKAL
A
E
-
HG
IVFGE
P
KT
D
I
D
K
I
R
TW
K
E
K
VINQL
-
T
G
G
LA
G
MA
KG
R
K
-
VKV
V
N
GL
GK
F
T
G
A
N
----
TL
E
VE
-
G
EN
G
KT
VI
N
FDN
A
I
IA
A
GSRP
I
--
QLP
F
I
PHE
DPRIWDST
D
AL
E
L
KE
VPERLLV
M
G
G
G
I
IGLE
M
G
T
V
Y
HA
LGS
QI
D
V
VEM
F
D
QV
I
PA
A
D
KD
I
V
-K
V
FTK
R
IS
KK
FN
L
M
L
E
T
K
V
T
AVE
AK
E
---
DG
I
Y
V
T
-
ME
GKK
AP
A
E
PQ
R
Y
--
D
A
V
LVAIGRVPN
G
KN
LD
A
GKA
GVE
V
DDRG
F
I
R
VD
KQL
RTN
V
PHI
F
AIGD
I
VGQPMLAHK
G
VH
EG
H
VAAE
V
I
--
AG
K
K
H
YF
DP
---
KV
IPS
I
A
YT
E
PEVAWVG
L
TE
KE
AK
E
K
GI
S
YE
T
A
T
FP
W
A
AS
GRA
I
A
S
D
CAD
G
MT
KLIFDKES
H
RVIGGAIVG
TN
G
GEL
L
G
EI
G
LAIE
M
---
G
C
D
A
EDIA
L
TIHAHPTL
H
E
SVG
LAAEVFEGSITDLPNPKAKKK
fig|749544.3.peg.1757
Escherichia coli MS 175-1
MTAGDKYIEVMMSTEIKTQV
V
V
L
G
A
GPAGY
S
AA
F
R
C
AD
L
GL
ET
VI
V
------
ERY
N
TLGG
V
CLNVGCIPSKALLH
V
A
KV
I
E
E
AKAL
A
E
-
HG
IVFGE
P
KT
D
I
D
K
I
R
TW
K
E
K
VINQL
-
T
G
G
LA
G
MA
KG
R
K
-
VKV
V
N
GL
GK
F
T
G
A
N
----
TL
E
VE
-
G
EN
G
KT
VI
N
FDN
A
I
IA
A
GSRP
I
--
QLP
F
I
PHE
DPRIWDST
D
AL
E
L
KE
VPERLLV
M
G
G
G
I
IGLE
M
G
T
V
Y
HA
LGS
QI
D
V
VEM
F
D
QV
I
PA
A
D
KD
I
V
-K
V
FTK
R
IS
KK
FN
L
M
L
E
T
K
V
T
AVE
AK
E
---
DG
I
Y
V
T
-
ME
GKK
AP
A
E
PQ
R
Y
--
D
A
V
LVAIGRVPN
G
KN
LD
A
GKA
GVE
V
DDRG
F
I
R
VD
KQL
RTN
V
PHI
F
AIGD
I
VGQPMLAHK
G
VH
EG
H
VAAE
V
I
--
AG
K
K
H
YF
DP
---
KV
IPS
I
A
YT
E
PEVAWVG
L
TE
KE
AK
E
K
GI
S
YE
T
A
T
FP
W
A
AS
GRA
I
A
S
D
CAD
G
MT
KLIFDKES
H
RVIGGAIVG
TN
G
GEL
L
G
EI
G
LAIE
M
---
G
C
D
A
EDIA
L
TIHAHPTL
H
E
SVG
LAAEVFEGSITDLPNPKAKKK
fig|749545.3.peg.1265
Escherichia coli MS 182-1
MTAGDKYIEVMMSTEIKTQV
V
V
L
G
A
GPAGY
S
AA
F
R
C
AD
L
GL
ET
VI
V
------
ERY
N
TLGG
V
CLNVGCIPSKALLH
V
A
KV
I
E
E
AKAL
A
E
-
HG
IVFGE
P
KT
D
I
D
K
I
R
TW
K
E
K
VINQL
-
T
G
G
LA
G
MA
KG
R
K
-
VKV
V
N
GL
GK
F
T
G
A
N
----
TL
E
VE
-
G
EN
G
KT
VI
N
FDN
A
I
IA
A
GSRP
I
--
QLP
F
I
PHE
DPRIWDST
D
AL
E
L
KE
VPERLLV
M
G
G
G
I
IGLE
M
G
T
V
Y
HA
LGS
QI
D
V
VEM
F
D
QV
I
PA
A
D
KD
I
V
-K
V
FTK
R
IS
KK
FN
L
M
L
E
T
K
V
T
AVE
AK
E
---
DG
I
Y
V
T
-
ME
GKK
AP
A
E
PQ
R
Y
--
D
A
V
LVAIGRVPN
G
KN
LD
A
GKA
GVE
V
DDRG
F
I
R
VD
KQL
RTN
V
PHI
F
AIGD
I
VGQPMLAHK
G
VH
EG
H
VAAE
V
I
--
AG
K
K
H
YF
DP
---
KV
IPS
I
A
YT
E
PEVAWVG
L
TE
KE
AK
E
K
GI
S
YE
T
A
T
FP
W
A
AS
GRA
I
A
S
D
CAD
G
MT
KLIFDKES
H
RVIGGAIVG
TN
G
GEL
L
G
EI
G
LAIE
M
---
G
C
D
A
EDIA
L
TIHAHPTL
H
E
SVG
LAAEVFEGSITDLPNPKAKKK
fig|749547.3.peg.3821
Escherichia coli MS 187-1
MTAGDKYIEVMMSTEIKTQV
V
V
L
G
A
GPAGY
S
AA
F
R
C
AD
L
GL
ET
VI
V
------
ERY
N
TLGG
V
CLNVGCIPSKALLH
V
A
KV
I
E
E
AKAL
A
E
-
HG
IVFGE
P
KT
D
I
D
K
I
R
TW
K
E
K
VINQL
-
T
G
G
LA
G
MA
KG
R
K
-
VKV
V
N
GL
GK
F
T
G
A
N
----
TL
E
VE
-
G
EN
G
KT
VI
N
FDN
A
I
IA
A
GSRP
I
--
QLP
F
I
PHE
DPRIWDST
D
AL
E
L
KE
VPERLLV
M
G
G
G
I
IGLE
M
G
T
V
Y
HA
LGS
QI
D
V
VEM
F
D
QV
I
PA
A
D
KD
I
V
-K
V
FTK
R
IS
KK
FN
L
M
L
E
T
K
V
T
AVE
AK
E
---
DG
I
Y
V
T
-
ME
GKK
AP
A
E
PQ
R
Y
--
D
A
V
LVAIGRVPN
G
KN
LD
A
GKA
GVE
V
DDRG
F
I
R
VD
KQL
RTN
V
PHI
F
AIGD
I
VGQPMLAHK
G
VH
EG
H
VAAE
V
I
--
AG
K
K
H
YF
DP
---
KV
IPS
I
A
YT
E
PEVAWVG
L
TE
KE
AK
E
K
GI
S
YE
T
A
T
FP
W
A
AS
GRA
I
A
S
D
CAD
G
MT
KLIFDKES
H
RVIGGAIVG
TN
G
GEL
L
G
EI
G
LAIE
M
---
G
C
D
A
EDIA
L
TIHAHPTL
H
E
SVG
LAAEVFEGSITDLPNPKAKKK
fig|749548.3.peg.4288
Escherichia coli MS 196-1
MTAGDKYIEVMMSTEIKTQV
V
V
L
G
A
GPAGY
S
AA
F
R
C
AD
L
GL
ET
VI
V
------
ERY
N
TLGG
V
CLNVGCIPSKALLH
V
A
KV
I
E
E
AKAL
A
E
-
HG
IVFGE
P
KT
D
I
D
K
I
R
TW
K
E
K
VINQL
-
T
G
G
LA
G
MA
KG
R
K
-
VKV
V
N
GL
GK
F
T
G
A
N
----
TL
E
VE
-
G
EN
G
KT
VI
N
FDN
A
I
IA
A
GSRP
I
--
QLP
F
I
PHE
DPRIWDST
D
AL
E
L
KE
VPERLLV
M
G
G
G
I
IGLE
M
G
T
V
Y
HA
LGS
QI
D
V
VEM
F
D
QV
I
PA
A
D
KD
I
V
-K
V
FTK
R
IS
KK
FN
L
M
L
E
T
K
V
T
AVE
AK
E
---
DG
I
Y
V
T
-
ME
GKK
AP
A
E
PQ
R
Y
--
D
A
V
LVAIGRVPN
G
KN
LD
A
GKA
GVE
V
DDRG
F
I
R
VD
KQL
RTN
V
PHI
F
AIGD
I
VGQPMLAHK
G
VH
EG
H
VAAE
V
I
--
AG
K
K
H
YF
DP
---
KV
IPS
I
A
YT
E
PEVAWVG
L
TE
KE
AK
E
K
GI
S
YE
T
A
T
FP
W
A
AS
GRA
I
A
S
D
CAD
G
MT
KLIFDKES
H
RVIGGAIVG
TN
G
GEL
L
G
EI
G
LAIE
M
---
G
C
D
A
EDIA
L
TIHAHPTL
H
E
SVG
LAAEVFEGSITDLPNPKAKKK
fig|749531.3.peg.4496
Escherichia coli MS 69-1
MTAGDKYIEVMMSTEIKTQV
V
V
L
G
A
GPAGY
S
AA
F
R
C
AD
L
GL
ET
VI
V
------
ERY
N
TLGG
V
CLNVGCIPSKALLH
V
A
KV
I
E
E
AKAL
A
E
-
HG
IVFGE
P
KT
D
I
D
K
I
R
TW
K
E
K
VINQL
-
T
G
G
LA
G
MA
KG
R
K
-
VKV
V
N
GL
GK
F
T
G
A
N
----
TL
E
VE
-
G
EN
G
KT
VI
N
FDN
A
I
IA
A
GSRP
I
--
QLP
F
I
PHE
DPRIWDST
D
AL
E
L
KE
VPERLLV
M
G
G
G
I
IGLE
M
G
T
V
Y
HA
LGS
QI
D
V
VEM
F
D
QV
I
PA
A
D
KD
I
V
-K
V
FTK
R
IS
KK
FN
L
M
L
E
T
K
V
T
AVE
AK
E
---
DG
I
Y
V
T
-
ME
GKK
AP
A
E
PQ
R
Y
--
D
A
V
LVAIGRVPN
G
KN
LD
A
GKA
GVE
V
DDRG
F
I
R
VD
KQL
RTN
V
PHI
F
AIGD
I
VGQPMLAHK
G
VH
EG
H
VAAE
V
I
--
AG
K
K
H
YF
DP
---
KV
IPS
I
A
YT
E
PEVAWVG
L
TE
KE
AK
E
K
GI
S
YE
T
A
T
FP
W
A
AS
GRA
I
A
S
D
CAD
G
MT
KLIFDKES
H
RVIGGAIVG
TN
G
GEL
L
G
EI
G
LAIE
M
---
G
C
D
A
EDIA
L
TIHAHPTL
H
E
SVG
LAAEVFEGSITDLPNPKAKKK
fig|749532.3.peg.4403
Escherichia coli MS 78-1
MTAGDKYIEVMMSTEIKTQV
V
V
L
G
A
GPAGY
S
AA
F
R
C
AD
L
GL
ET
VI
V
------
ERY
N
TLGG
V
CLNVGCIPSKALLH
V
A
KV
I
E
E
AKAL
A
E
-
HG
IVFGE
P
KT
D
I
D
K
I
R
TW
K
E
K
VINQL
-
T
G
G
LA
G
MA
KG
R
K
-
VKV
V
N
GL
GK
F
T
G
A
N
----
TL
E
VE
-
G
EN
G
KT
VI
N
FDN
A
I
IA
A
GSRP
I
--
QLP
F
I
PHE
DPRIWDST
D
AL
E
L
KE
VPERLLV
M
G
G
G
I
IGLE
M
G
T
V
Y
HA
LGS
QI
D
V
VEM
F
D
QV
I
PA
A
D
KD
I
V
-K
V
FTK
R
IS
KK
FN
L
M
L
E
T
K
V
T
AVE
AK
E
---
DG
I
Y
V
T
-
ME
GKK
AP
A
E
PQ
R
Y
--
D
A
V
LVAIGRVPN
G
KN
LD
A
GKA
GVE
V
DDRG
F
I
R
VD
KQL
RTN
V
PHI
F
AIGD
I
VGQPMLAHK
G
VH
EG
H
VAAE
V
I
--
AG
K
K
H
YF
DP
---
KV
IPS
I
A
YT
E
PEVAWVG
L
TE
KE
AK
E
K
GI
S
YE
T
A
T
FP
W
A
AS
GRA
I
A
S
D
CAD
G
MT
KLIFDKES
H
RVIGGAIVG
TN
G
GEL
L
G
EI
G
LAIE
M
---
G
C
D
A
EDIA
L
TIHAHPTL
H
E
SVG
LAAEVFEGSITDLPNPKAKKK
fig|585395.4.peg.116
Escherichia coli O103:H2 str. 12009
MTAGDKYIEVMMSTEIKTQV
V
V
L
G
A
GPAGY
S
AA
F
R
C
AD
L
GL
ET
VI
V
------
ERY
N
TLGG
V
CLNVGCIPSKALLH
V
A
KV
I
E
E
AKAL
A
E
-
HG
IVFGE
P
KT
D
I
D
K
I
R
TW
K
E
K
VINQL
-
T
G
G
LA
G
MA
KG
R
K
-
VKV
V
N
GL
GK
F
T
G
A
N
----
TL
E
VE
-
G
EN
G
KT
VI
N
FDN
A
I
IA
A
GSRP
I
--
QLP
F
I
PHE
DPRIWDST
D
AL
E
L
KE
VPERLLV
M
G
G
G
I
IGLE
M
G
T
V
Y
HA
LGS
QI
D
V
VEM
F
D
QV
I
PA
A
D
KD
I
V
-K
V
FTK
R
IS
KK
FN
L
M
L
E
T
K
V
T
AVE
AK
E
---
DG
I
Y
V
T
-
ME
GKK
AP
A
E
PQ
R
Y
--
D
A
V
LVAIGRVPN
G
KN
LD
A
GKA
GVE
V
DDRG
F
I
R
VD
KQL
RTN
V
PHI
F
AIGD
I
VGQPMLAHK
G
VH
EG
H
VAAE
V
I
--
AG
K
K
H
YF
DP
---
KV
IPS
I
A
YT
E
PEVAWVG
L
TE
KE
AK
E
K
GI
S
YE
T
A
T
FP
W
A
AS
GRA
I
A
S
D
CAD
G
MT
KLIFDKES
H
RVIGGAIVG
TN
G
GEL
L
G
EI
G
LAIE
M
---
G
C
D
A
EDIA
L
TIHAHPTL
H
E
SVG
LAAEVFEGSITDLPNPKAKKK
fig|585396.4.peg.117
Escherichia coli O111:H- str. 11128
MTAGDKYIEVMMSTEIKTQV
V
V
L
G
A
GPAGY
S
AA
F
R
C
AD
L
GL
ET
VI
V
------
ERY
N
TLGG
V
CLNVGCIPSKALLH
V
A
KV
I
E
E
AKAL
A
E
-
HG
IVFGE
P
KT
D
I
D
K
I
R
TW
K
E
K
VINQL
-
T
G
G
LA
G
MA
KG
R
K
-
VKV
V
N
GL
GK
F
T
G
A
N
----
TL
E
VE
-
G
EN
G
KT
VI
N
FDN
A
I
IA
A
GSRP
I
--
QLP
F
I
PHE
DPRIWDST
D
AL
E
L
KE
VPERLLV
M
G
G
G
I
IGLE
M
G
T
V
Y
HA
LGS
QI
D
V
VEM
F
D
QV
I
PA
A
D
KD
I
V
-K
V
FTK
R
IS
KK
FN
L
M
L
E
T
K
V
T
AVE
AK
E
---
DG
I
Y
V
T
-
ME
GKK
AP
A
E
PQ
R
Y
--
D
A
V
LVAIGRVPN
G
KN
LD
A
GKA
GVE
V
DDRG
F
I
R
VD
KQL
RTN
V
PHI
F
AIGD
I
VGQPMLAHK
G
VH
EG
H
VAAE
V
I
--
AG
K
K
H
YF
DP
---
KV
IPS
I
A
YT
E
PEVAWVG
L
TE
KE
AK
E
K
GI
S
YE
T
A
T
FP
W
A
AS
GRA
I
A
S
D
CAD
G
MT
KLIFDKES
H
RVIGGAIVG
TN
G
GEL
L
G
EI
G
LAIE
M
---
G
C
D
A
EDIA
L
TIHAHPTL
H
E
SVG
LAAEVFEGSITDLPNPKAKKK
fig|573235.3.peg.120
Escherichia coli O26:H11 str. 11368
MTAGDKYIEVMMSTEIKTQV
V
V
L
G
A
GPAGY
S
AA
F
R
C
AD
L
GL
ET
VI
V
------
ERY
N
TLGG
V
CLNVGCIPSKALLH
V
A
KV
I
E
E
AKAL
A
E
-
HG
IVFGE
P
KT
D
I
D
K
I
R
TW
K
E
K
VINQL
-
T
G
G
LA
G
MA
KG
R
K
-
VKV
V
N
GL
GK
F
T
G
A
N
----
TL
E
VE
-
G
EN
G
KT
VI
N
FDN
A
I
IA
A
GSRP
I
--
QLP
F
I
PHE
DPRIWDST
D
AL
E
L
KE
VPERLLV
M
G
G
G
I
IGLE
M
G
T
V
Y
HA
LGS
QI
D
V
VEM
F
D
QV
I
PA
A
D
KD
I
V
-K
V
FTK
R
IS
KK
FN
L
M
L
E
T
K
V
T
AVE
AK
E
---
DG
I
Y
V
T
-
ME
GKK
AP
A
E
PQ
R
Y
--
D
A
V
LVAIGRVPN
G
KN
LD
A
GKA
GVE
V
DDRG
F
I
R
VD
KQL
RTN
V
PHI
F
AIGD
I
VGQPMLAHK
G
VH
EG
H
VAAE
V
I
--
AG
K
K
H
YF
DP
---
KV
IPS
I
A
YT
E
PEVAWVG
L
TE
KE
AK
E
K
GI
S
YE
T
A
T
FP
W
A
AS
GRA
I
A
S
D
CAD
G
MT
KLIFDKES
H
RVIGGAIVG
TN
G
GEL
L
G
EI
G
LAIE
M
---
G
C
D
A
EDIA
L
TIHAHPTL
H
E
SVG
LAAEVFEGSITDLPNPKAKKK
fig|409438.11.peg.233
Escherichia coli SE11
MTAGDKYIEVMMSTEIKTQV
V
V
L
G
A
GPAGY
S
AA
F
R
C
AD
L
GL
ET
VI
V
------
ERY
N
TLGG
V
CLNVGCIPSKALLH
V
A
KV
I
E
E
AKAL
A
E
-
HG
IVFGE
P
KT
D
I
D
K
I
R
TW
K
E
K
VINQL
-
T
G
G
LA
G
MA
KG
R
K
-
VKV
V
N
GL
GK
F
T
G
A
N
----
TL
E
VE
-
G
EN
G
KT
VI
N
FDN
A
I
IA
A
GSRP
I
--
QLP
F
I
PHE
DPRIWDST
D
AL
E
L
KE
VPERLLV
M
G
G
G
I
IGLE
M
G
T
V
Y
HA
LGS
QI
D
V
VEM
F
D
QV
I
PA
A
D
KD
I
V
-K
V
FTK
R
IS
KK
FN
L
M
L
E
T
K
V
T
AVE
AK
E
---
DG
I
Y
V
T
-
ME
GKK
AP
A
E
PQ
R
Y
--
D
A
V
LVAIGRVPN
G
KN
LD
A
GKA
GVE
V
DDRG
F
I
R
VD
KQL
RTN
V
PHI
F
AIGD
I
VGQPMLAHK
G
VH
EG
H
VAAE
V
I
--
AG
K
K
H
YF
DP
---
KV
IPS
I
A
YT
E
PEVAWVG
L
TE
KE
AK
E
K
GI
S
YE
T
A
T
FP
W
A
AS
GRA
I
A
S
D
CAD
G
MT
KLIFDKES
H
RVIGGAIVG
TN
G
GEL
L
G
EI
G
LAIE
M
---
G
C
D
A
EDIA
L
TIHAHPTL
H
E
SVG
LAAEVFEGSITDLPNPKAKKK
fig|656443.3.peg.251
Escherichia coli TA271
MTAGDKYIEVMMSTEIKTQV
V
V
L
G
A
GPAGY
S
AA
F
R
C
AD
L
GL
ET
VI
V
------
ERY
N
TLGG
V
CLNVGCIPSKALLH
V
A
KV
I
E
E
AKAL
A
E
-
HG
IVFGE
P
KT
D
I
D
K
I
R
TW
K
E
K
VINQL
-
T
G
G
LA
G
MA
KG
R
K
-
VKV
V
N
GL
GK
F
T
G
A
N
----
TL
E
VE
-
G
EN
G
KT
VI
N
FDN
A
I
IA
A
GSRP
I
--
QLP
F
I
PHE
DPRIWDST
D
AL
E
L
KE
VPERLLV
M
G
G
G
I
IGLE
M
G
T
V
Y
HA
LGS
QI
D
V
VEM
F
D
QV
I
PA
A
D
KD
I
V
-K
V
FTK
R
IS
KK
FN
L
M
L
E
T
K
V
T
AVE
AK
E
---
DG
I
Y
V
T
-
ME
GKK
AP
A
E
PQ
R
Y
--
D
A
V
LVAIGRVPN
G
KN
LD
A
GKA
GVE
V
DDRG
F
I
R
VD
KQL
RTN
V
PHI
F
AIGD
I
VGQPMLAHK
G
VH
EG
H
VAAE
V
I
--
AG
K
K
H
YF
DP
---
KV
IPS
I
A
YT
E
PEVAWVG
L
TE
KE
AK
E
K
GI
S
YE
T
A
T
FP
W
A
AS
GRA
I
A
S
D
CAD
G
MT
KLIFDKES
H
RVIGGAIVG
TN
G
GEL
L
G
EI
G
LAIE
M
---
G
C
D
A
EDIA
L
TIHAHPTL
H
E
SVG
LAAEVFEGSITDLPNPKAKKK
fig|656444.3.peg.455
Escherichia coli TA280
MTAGDKYIEVMMSTEIKTQV
V
V
L
G
A
GPAGY
S
AA
F
R
C
AD
L
GL
ET
VI
V
------
ERY
N
TLGG
V
CLNVGCIPSKALLH
V
A
KV
I
E
E
AKAL
A
E
-
HG
IVFGE
P
KT
D
I
D
K
I
R
TW
K
E
K
VINQL
-
T
G
G
LA
G
MA
KG
R
K
-
VKV
V
N
GL
GK
F
T
G
A
N
----
TL
E
VE
-
G
EN
G
KT
VI
N
FDN
A
I
IA
A
GSRP
I
--
QLP
F
I
PHE
DPRIWDST
D
AL
E
L
KE
VPERLLV
M
G
G
G
I
IGLE
M
G
T
V
Y
HA
LGS
QI
D
V
VEM
F
D
QV
I
PA
A
D
KD
I
V
-K
V
FTK
R
IS
KK
FN
L
M
L
E
T
K
V
T
AVE
AK
E
---
DG
I
Y
V
T
-
ME
GKK
AP
A
E
PQ
R
Y
--
D
A
V
LVAIGRVPN
G
KN
LD
A
GKA
GVE
V
DDRG
F
I
R
VD
KQL
RTN
V
PHI
F
AIGD
I
VGQPMLAHK
G
VH
EG
H
VAAE
V
I
--
AG
K
K
H
YF
DP
---
KV
IPS
I
A
YT
E
PEVAWVG
L
TE
KE
AK
E
K
GI
S
YE
T
A
T
FP
W
A
AS
GRA
I
A
S
D
CAD
G
MT
KLIFDKES
H
RVIGGAIVG
TN
G
GEL
L
G
EI
G
LAIE
M
---
G
C
D
A
EDIA
L
TIHAHPTL
H
E
SVG
LAAEVFEGSITDLPNPKAKKK
fig|566546.3.peg.1611
Escherichia coli W
MTAGDKYIEVMMSTEIKTQV
V
V
L
G
A
GPAGY
S
AA
F
R
C
AD
L
GL
ET
VI
V
------
ERY
N
TLGG
V
CLNVGCIPSKALLH
V
A
KV
I
E
E
AKAL
A
E
-
HG
IVFGE
P
KT
D
I
D
K
I
R
TW
K
E
K
VINQL
-
T
G
G
LA
G
MA
KG
R
K
-
VKV
V
N
GL
GK
F
T
G
A
N
----
TL
E
VE
-
G
EN
G
KT
VI
N
FDN
A
I
IA
A
GSRP
I
--
QLP
F
I
PHE
DPRIWDST
D
AL
E
L
KE
VPERLLV
M
G
G
G
I
IGLE
M
G
T
V
Y
HA
LGS
QI
D
V
VEM
F
D
QV
I
PA
A
D
KD
I
V
-K
V
FTK
R
IS
KK
FN
L
M
L
E
T
K
V
T
AVE
AK
E
---
DG
I
Y
V
T
-
ME
GKK
AP
A
E
PQ
R
Y
--
D
A
V
LVAIGRVPN
G
KN
LD
A
GKA
GVE
V
DDRG
F
I
R
VD
KQL
RTN
V
PHI
F
AIGD
I
VGQPMLAHK
G
VH
EG
H
VAAE
V
I
--
AG
K
K
H
YF
DP
---
KV
IPS
I
A
YT
E
PEVAWVG
L
TE
KE
AK
E
K
GI
S
YE
T
A
T
FP
W
A
AS
GRA
I
A
S
D
CAD
G
MT
KLIFDKES
H
RVIGGAIVG
TN
G
GEL
L
G
EI
G
LAIE
M
---
G
C
D
A
EDIA
L
TIHAHPTL
H
E
SVG
LAAEVFEGSITDLPNPKAKKK
fig|566546.4.peg.112
Escherichia coli W
MTAGDKYIEVMMSTEIKTQV
V
V
L
G
A
GPAGY
S
AA
F
R
C
AD
L
GL
ET
VI
V
------
ERY
N
TLGG
V
CLNVGCIPSKALLH
V
A
KV
I
E
E
AKAL
A
E
-
HG
IVFGE
P
KT
D
I
D
K
I
R
TW
K
E
K
VINQL
-
T
G
G
LA
G
MA
KG
R
K
-
VKV
V
N
GL
GK
F
T
G
A
N
----
TL
E
VE
-
G
EN
G
KT
VI
N
FDN
A
I
IA
A
GSRP
I
--
QLP
F
I
PHE
DPRIWDST
D
AL
E
L
KE
VPERLLV
M
G
G
G
I
IGLE
M
G
T
V
Y
HA
LGS
QI
D
V
VEM
F
D
QV
I
PA
A
D
KD
I
V
-K
V
FTK
R
IS
KK
FN
L
M
L
E
T
K
V
T
AVE
AK
E
---
DG
I
Y
V
T
-
ME
GKK
AP
A
E
PQ
R
Y
--
D
A
V
LVAIGRVPN
G
KN
LD
A
GKA
GVE
V
DDRG
F
I
R
VD
KQL
RTN
V
PHI
F
AIGD
I
VGQPMLAHK
G
VH
EG
H
VAAE
V
I
--
AG
K
K
H
YF
DP
---
KV
IPS
I
A
YT
E
PEVAWVG
L
TE
KE
AK
E
K
GI
S
YE
T
A
T
FP
W
A
AS
GRA
I
A
S
D
CAD
G
MT
KLIFDKES
H
RVIGGAIVG
TN
G
GEL
L
G
EI
G
LAIE
M
---
G
C
D
A
EDIA
L
TIHAHPTL
H
E
SVG
LAAEVFEGSITDLPNPKAKKK
fig|562.376.peg.1187
Escherichia coli WV_060327
MTAGDKYIEVMMSTEIKTQV
V
V
L
G
A
GPAGY
S
AA
F
R
C
AD
L
GL
ET
VI
V
------
ERY
N
TLGG
V
CLNVGCIPSKALLH
V
A
KV
I
E
E
AKAL
A
E
-
HG
IVFGE
P
KT
D
I
D
K
I
R
TW
K
E
K
VINQL
-
T
G
G
LA
G
MA
KG
R
K
-
VKV
V
N
GL
GK
F
T
G
A
N
----
TL
E
VE
-
G
EN
G
KT
VI
N
FDN
A
I
IA
A
GSRP
I
--
QLP
F
I
PHE
DPRIWDST
D
AL
E
L
KE
VPERLLV
M
G
G
G
I
IGLE
M
G
T
V
Y
HA
LGS
QI
D
V
VEM
F
D
QV
I
PA
A
D
KD
I
V
-K
V
FTK
R
IS
KK
FN
L
M
L
E
T
K
V
T
AVE
AK
E
---
DG
I
Y
V
T
-
ME
GKK
AP
A
E
PQ
R
Y
--
D
A
V
LVAIGRVPN
G
KN
LD
A
GKA
GVE
V
DDRG
F
I
R
VD
KQL
RTN
V
PHI
F
AIGD
I
VGQPMLAHK
G
VH
EG
H
VAAE
V
I
--
AG
K
K
H
YF
DP
---
KV
IPS
I
A
YT
E
PEVAWVG
L
TE
KE
AK
E
K
GI
S
YE
T
A
T
FP
W
A
AS
GRA
I
A
S
D
CAD
G
MT
KLIFDKES
H
RVIGGAIVG
TN
G
GEL
L
G
EI
G
LAIE
M
---
G
C
D
A
EDIA
L
TIHAHPTL
H
E
SVG
LAAEVFEGSITDLPNPKAKKK
fig|316385.7.peg.96
Escherichia coli str. K-12 substr. DH10B
MTAGDKYIEVMMSTEIKTQV
V
V
L
G
A
GPAGY
S
AA
F
R
C
AD
L
GL
ET
VI
V
------
ERY
N
TLGG
V
CLNVGCIPSKALLH
V
A
KV
I
E
E
AKAL
A
E
-
HG
IVFGE
P
KT
D
I
D
K
I
R
TW
K
E
K
VINQL
-
T
G
G
LA
G
MA
KG
R
K
-
VKV
V
N
GL
GK
F
T
G
A
N
----
TL
E
VE
-
G
EN
G
KT
VI
N
FDN
A
I
IA
A
GSRP
I
--
QLP
F
I
PHE
DPRIWDST
D
AL
E
L
KE
VPERLLV
M
G
G
G
I
IGLE
M
G
T
V
Y
HA
LGS
QI
D
V
VEM
F
D
QV
I
PA
A
D
KD
I
V
-K
V
FTK
R
IS
KK
FN
L
M
L
E
T
K
V
T
AVE
AK
E
---
DG
I
Y
V
T
-
ME
GKK
AP
A
E
PQ
R
Y
--
D
A
V
LVAIGRVPN
G
KN
LD
A
GKA
GVE
V
DDRG
F
I
R
VD
KQL
RTN
V
PHI
F
AIGD
I
VGQPMLAHK
G
VH
EG
H
VAAE
V
I
--
AG
K
K
H
YF
DP
---
KV
IPS
I
A
YT
E
PEVAWVG
L
TE
KE
AK
E
K
GI
S
YE
T
A
T
FP
W
A
AS
GRA
I
A
S
D
CAD
G
MT
KLIFDKES
H
RVIGGAIVG
TN
G
GEL
L
G
EI
G
LAIE
M
---
G
C
D
A
EDIA
L
TIHAHPTL
H
E
SVG
LAAEVFEGSITDLPNPKAKKK
fig|511145.12.peg.118
Escherichia coli str. K-12 substr. MG1655
MTAGDKYIEVMMSTEIKTQV
V
V
L
G
A
GPAGY
S
AA
F
R
C
AD
L
GL
ET
VI
V
------
ERY
N
TLGG
V
CLNVGCIPSKALLH
V
A
KV
I
E
E
AKAL
A
E
-
HG
IVFGE
P
KT
D
I
D
K
I
R
TW
K
E
K
VINQL
-
T
G
G
LA
G
MA
KG
R
K
-
VKV
V
N
GL
GK
F
T
G
A
N
----
TL
E
VE
-
G
EN
G
KT
VI
N
FDN
A
I
IA
A
GSRP
I
--
QLP
F
I
PHE
DPRIWDST
D
AL
E
L
KE
VPERLLV
M
G
G
G
I
IGLE
M
G
T
V
Y
HA
LGS
QI
D
V
VEM
F
D
QV
I
PA
A
D
KD
I
V
-K
V
FTK
R
IS
KK
FN
L
M
L
E
T
K
V
T
AVE
AK
E
---
DG
I
Y
V
T
-
ME
GKK
AP
A
E
PQ
R
Y
--
D
A
V
LVAIGRVPN
G
KN
LD
A
GKA
GVE
V
DDRG
F
I
R
VD
KQL
RTN
V
PHI
F
AIGD
I
VGQPMLAHK
G
VH
EG
H
VAAE
V
I
--
AG
K
K
H
YF
DP
---
KV
IPS
I
A
YT
E
PEVAWVG
L
TE
KE
AK
E
K
GI
S
YE
T
A
T
FP
W
A
AS
GRA
I
A
S
D
CAD
G
MT
KLIFDKES
H
RVIGGAIVG
TN
G
GEL
L
G
EI
G
LAIE
M
---
G
C
D
A
EDIA
L
TIHAHPTL
H
E
SVG
LAAEVFEGSITDLPNPKAKKK
fig|511145.6.peg.118
Escherichia coli str. K-12 substr. MG1655
MTAGDKYIEVMMSTEIKTQV
V
V
L
G
A
GPAGY
S
AA
F
R
C
AD
L
GL
ET
VI
V
------
ERY
N
TLGG
V
CLNVGCIPSKALLH
V
A
KV
I
E
E
AKAL
A
E
-
HG
IVFGE
P
KT
D
I
D
K
I
R
TW
K
E
K
VINQL
-
T
G
G
LA
G
MA
KG
R
K
-
VKV
V
N
GL
GK
F
T
G
A
N
----
TL
E
VE
-
G
EN
G
KT
VI
N
FDN
A
I
IA
A
GSRP
I
--
QLP
F
I
PHE
DPRIWDST
D
AL
E
L
KE
VPERLLV
M
G
G
G
I
IGLE
M
G
T
V
Y
HA
LGS
QI
D
V
VEM
F
D
QV
I
PA
A
D
KD
I
V
-K
V
FTK
R
IS
KK
FN
L
M
L
E
T
K
V
T
AVE
AK
E
---
DG
I
Y
V
T
-
ME
GKK
AP
A
E
PQ
R
Y
--
D
A
V
LVAIGRVPN
G
KN
LD
A
GKA
GVE
V
DDRG
F
I
R
VD
KQL
RTN
V
PHI
F
AIGD
I
VGQPMLAHK
G
VH
EG
H
VAAE
V
I
--
AG
K
K
H
YF
DP
---
KV
IPS
I
A
YT
E
PEVAWVG
L
TE
KE
AK
E
K
GI
S
YE
T
A
T
FP
W
A
AS
GRA
I
A
S
D
CAD
G
MT
KLIFDKES
H
RVIGGAIVG
TN
G
GEL
L
G
EI
G
LAIE
M
---
G
C
D
A
EDIA
L
TIHAHPTL
H
E
SVG
LAAEVFEGSITDLPNPKAKKK
fig|344610.7.peg.1623
Escherichia coli 53638
MTAGDKYIEVMMSTEIKTQV
V
V
L
G
A
GPAGY
S
AA
F
R
C
AD
L
GL
ET
VI
V
------
ERY
N
TLGG
V
CLNVGCIPSKALLH
V
A
KV
I
E
E
AKAL
A
E
-
HG
IVFGE
P
KT
D
I
D
K
I
R
TW
K
E
K
VINQL
-
T
G
G
LA
G
MA
KG
R
K
-
VKV
V
N
GL
GK
F
T
G
A
N
----
TL
E
VE
-
G
EN
G
KT
VI
N
FDN
A
I
IA
A
GSRP
I
--
QLP
F
I
PHE
DPRIWDST
D
AL
E
L
KE
VPERLLV
M
G
G
G
I
IGLE
M
G
T
V
Y
HA
LGS
QI
D
V
VEM
F
D
QV
I
PA
A
D
KD
I
V
-K
V
FTK
R
IS
KK
FN
L
M
L
E
T
K
V
T
AVE
AK
E
---
DG
I
Y
V
T
-
ME
GKK
AP
A
E
PQ
R
Y
--
D
A
V
LVAIGRVPN
G
KN
LD
A
GKA
GVE
V
DDRG
F
I
R
VD
KQL
RTN
V
PHI
F
AIGD
I
VGQPMLAHK
G
VH
EG
H
VAAE
V
I
--
AG
K
K
H
YF
DP
---
KV
IPS
I
A
YT
E
PEVAWVG
L
TE
KE
AK
E
K
GI
S
F
E
T
A
T
FP
W
A
AS
GRA
I
A
S
D
CAD
G
MT
KLIFDKES
H
RVIGGAIVG
TN
G
GEL
L
G
EI
G
LAIE
M
---
G
C
D
A
EDIA
L
TIHAHPTL
H
E
SVG
LAAEVFEGSITDLPNPKAKKK
fig|481805.3.peg.3807
Escherichia coli ATCC 8739
MTAGDKYIEVMMSTEIKTQV
V
V
L
G
A
GPAGY
S
AA
F
R
C
AD
L
GL
ET
VI
V
------
ERY
N
TLGG
V
CLNVGCIPSKALLH
V
A
KV
I
E
E
AKAL
A
E
-
HG
IVFGE
P
KT
D
I
D
K
I
R
TW
K
E
K
VINQL
-
T
G
G
LA
G
MA
KG
R
K
-
VKV
V
N
GL
GK
F
T
G
A
N
----
TL
E
VE
-
G
EN
G
KT
VI
N
FDN
A
I
IA
A
GSRP
I
--
QLP
F
I
PHE
DPRIWDST
D
AL
E
L
KE
VPERLLV
M
G
G
G
I
IGLE
M
G
T
V
Y
HA
LGS
QI
D
V
VEM
F
D
QV
I
PA
A
D
KD
I
V
-K
V
FTK
R
IS
KK
FN
L
M
L
E
T
K
V
T
AVE
AK
E
---
DG
I
Y
V
T
-
ME
GKK
AP
A
E
PQ
R
Y
--
D
A
V
LVAIGRVPN
G
KN
LD
A
GKA
GVE
V
DDRG
F
I
R
VD
KQL
RTN
V
PHI
F
AIGD
I
VGQPMLAHK
G
VH
EG
H
VAAE
V
I
--
AG
K
K
H
YF
DP
---
KV
IPS
I
A
YT
E
PEVAWVG
L
TE
KE
AK
E
K
GI
S
F
E
T
A
T
FP
W
A
AS
GRA
I
A
S
D
CAD
G
MT
KLIFDKES
H
RVIGGAIVG
TN
G
GEL
L
G
EI
G
LAIE
M
---
G
C
D
A
EDIA
L
TIHAHPTL
H
E
SVG
LAAEVFEGSITDLPNPKAKKK
fig|481805.6.peg.3786
Escherichia coli ATCC 8739
MTAGDKYIEVMMSTEIKTQV
V
V
L
G
A
GPAGY
S
AA
F
R
C
AD
L
GL
ET
VI
V
------
ERY
N
TLGG
V
CLNVGCIPSKALLH
V
A
KV
I
E
E
AKAL
A
E
-
HG
IVFGE
P
KT
D
I
D
K
I
R
TW
K
E
K
VINQL
-
T
G
G
LA
G
MA
KG
R
K
-
VKV
V
N
GL
GK
F
T
G
A
N
----
TL
E
VE
-
G
EN
G
KT
VI
N
FDN
A
I
IA
A
GSRP
I
--
QLP
F
I
PHE
DPRIWDST
D
AL
E
L
KE
VPERLLV
M
G
G
G
I
IGLE
M
G
T
V
Y
HA
LGS
QI
D
V
VEM
F
D
QV
I
PA
A
D
KD
I
V
-K
V
FTK
R
IS
KK
FN
L
M
L
E
T
K
V
T
AVE
AK
E
---
DG
I
Y
V
T
-
ME
GKK
AP
A
E
PQ
R
Y
--
D
A
V
LVAIGRVPN
G
KN
LD
A
GKA
GVE
V
DDRG
F
I
R
VD
KQL
RTN
V
PHI
F
AIGD
I
VGQPMLAHK
G
VH
EG
H
VAAE
V
I
--
AG
K
K
H
YF
DP
---
KV
IPS
I
A
YT
E
PEVAWVG
L
TE
KE
AK
E
K
GI
S
F
E
T
A
T
FP
W
A
AS
GRA
I
A
S
D
CAD
G
MT
KLIFDKES
H
RVIGGAIVG
TN
G
GEL
L
G
EI
G
LAIE
M
---
G
C
D
A
EDIA
L
TIHAHPTL
H
E
SVG
LAAEVFEGSITDLPNPKAKKK
fig|656393.3.peg.733
Escherichia coli H299
MTAGDKYIEVMMSTEIKTQV
V
V
L
G
A
GPAGY
S
AA
F
R
C
AD
L
GL
ET
VI
V
------
ERY
A
TLGG
V
CLNVGCIPSKALLH
V
A
KV
I
E
E
AKAL
A
E
-
HG
IVFGE
P
KT
D
I
D
K
I
R
TW
K
E
K
VINQL
-
T
G
G
LA
G
MA
KG
R
K
-
VKV
V
N
GL
GK
F
T
G
A
N
----
TL
E
VE
-
G
EN
G
KT
VI
N
FDN
A
I
IA
A
GSRP
I
--
QLP
F
I
PHE
DPRIWDST
D
AL
E
L
KE
VPERLLV
M
G
G
G
I
IGLE
M
G
T
V
Y
HA
LGS
QI
D
V
VEM
F
D
QV
I
PA
A
D
KD
I
V
-K
V
FTK
R
IS
KK
FN
L
M
L
E
T
K
V
T
AVE
AK
E
---
DG
I
Y
V
T
-
ME
GKK
AP
A
E
PQ
R
Y
--
D
A
V
LVAIGRVPN
G
KN
LD
A
GKA
GVE
V
DDRG
F
I
R
VD
KQL
RTN
V
PHI
F
AIGD
I
VGQPMLAHK
G
VH
EG
H
VAAE
V
I
--
AG
K
K
H
YF
DP
---
KV
IPS
I
A
YT
E
PEVAWVG
L
TE
KE
AK
E
K
GI
S
YE
T
A
T
FP
W
A
AS
GRA
I
A
S
D
CAD
G
MT
KLIFDKES
H
RVIGGAIVG
TN
G
GEL
L
G
EI
G
LAIE
M
---
G
C
D
A
EDIA
L
TIHAHPTL
H
E
SVG
LAAEVFEGSITDLPNPKAKKK
fig|216592.1.peg.4292
Escherichia coli 042 (13-495/495)
AGDKYIEVMMSTEIKTQV
V
V
L
G
A
GPAGY
S
AA
F
R
C
AD
L
GL
ET
VI
V
------
ERY
N
TLGG
V
CLNVGCIPSKALLH
V
A
KV
I
E
E
AKAL
A
E
-
HG
IVFGE
P
KT
D
I
D
K
I
R
TW
K
E
K
VINQL
-
T
G
G
LA
G
MA
KG
R
K
-
VKV
V
N
GL
GK
F
T
G
A
N
----
TL
E
VE
-
G
EN
G
KT
VI
N
FDN
A
I
IA
A
GSRP
I
--
QLP
F
I
PHE
DPRIWDST
D
AL
E
L
KE
VPERLLV
M
G
G
G
I
IGLE
M
G
T
V
Y
HA
LGS
QI
D
V
VEM
F
D
QV
I
PA
A
D
KD
I
V
-K
V
FTK
R
IS
KK
FN
L
M
L
E
T
K
V
T
AVE
AK
E
---
DG
I
Y
V
T
-
ME
GKK
AP
A
E
PQ
R
Y
--
D
A
V
LVAIGRVPN
G
KN
LD
A
GKA
GVE
V
DDRG
F
I
R
VD
KQL
RTN
V
PHI
F
AIGD
I
VGQPMLAHK
G
VH
EG
H
VAAE
V
I
--
AG
K
K
H
YF
DP
---
KV
IPS
I
A
YT
E
PEVAWVG
L
TE
KE
AK
E
K
GI
S
YE
T
A
T
FP
W
A
AS
GRA
I
A
S
D
CAD
G
MT
KLIFDKES
H
RVIGGAIVG
TN
G
GEL
L
G
EI
G
LAIE
M
---
G
C
D
A
EDIA
L
TIHAHPTL
H
E
SVG
LAAEVFEGSITDLPNPKAKKK
fig|562.371.peg.4059
Escherichia coli 1044A (13-495/495)
AGDKYIEVMMSTEIKTQV
V
V
L
G
A
GPAGY
S
AA
F
R
C
AD
L
GL
ET
VI
V
------
ERY
N
TLGG
V
CLNVGCIPSKALLH
V
A
KV
I
E
E
AKAL
A
E
-
HG
IVFGE
P
KT
D
I
D
K
I
R
TW
K
E
K
VINQL
-
T
G
G
LA
G
MA
KG
R
K
-
VKV
V
N
GL
GK
F
T
G
A
N
----
TL
E
VE
-
G
EN
G
KT
VI
N
FDN
A
I
IA
A
GSRP
I
--
QLP
F
I
PHE
DPRIWDST
D
AL
E
L
KE
VPERLLV
M
G
G
G
I
IGLE
M
G
T
V
Y
HA
LGS
QI
D
V
VEM
F
D
QV
I
PA
A
D
KD
I
V
-K
V
FTK
R
IS
KK
FN
L
M
L
E
T
K
V
T
AVE
AK
E
---
DG
I
Y
V
T
-
ME
GKK
AP
A
E
PQ
R
Y
--
D
A
V
LVAIGRVPN
G
KN
LD
A
GKA
GVE
V
DDRG
F
I
R
VD
KQL
RTN
V
PHI
F
AIGD
I
VGQPMLAHK
G
VH
EG
H
VAAE
V
I
--
AG
K
K
H
YF
DP
---
KV
IPS
I
A
YT
E
PEVAWVG
L
TE
KE
AK
E
K
GI
S
YE
T
A
T
FP
W
A
AS
GRA
I
A
S
D
CAD
G
MT
KLIFDKES
H
RVIGGAIVG
TN
G
GEL
L
G
EI
G
LAIE
M
---
G
C
D
A
EDIA
L
TIHAHPTL
H
E
SVG
LAAEVFEGSITDLPNPKAKKK
fig|562.373.peg.2146
Escherichia coli 1125A (13-495/495)
AGDKYIEVMMSTEIKTQV
V
V
L
G
A
GPAGY
S
AA
F
R
C
AD
L
GL
ET
VI
V
------
ERY
N
TLGG
V
CLNVGCIPSKALLH
V
A
KV
I
E
E
AKAL
A
E
-
HG
IVFGE
P
KT
D
I
D
K
I
R
TW
K
E
K
VINQL
-
T
G
G
LA
G
MA
KG
R
K
-
VKV
V
N
GL
GK
F
T
G
A
N
----
TL
E
VE
-
G
EN
G
KT
VI
N
FDN
A
I
IA
A
GSRP
I
--
QLP
F
I
PHE
DPRIWDST
D
AL
E
L
KE
VPERLLV
M
G
G
G
I
IGLE
M
G
T
V
Y
HA
LGS
QI
D
V
VEM
F
D
QV
I
PA
A
D
KD
I
V
-K
V
FTK
R
IS
KK
FN
L
M
L
E
T
K
V
T
AVE
AK
E
---
DG
I
Y
V
T
-
ME
GKK
AP
A
E
PQ
R
Y
--
D
A
V
LVAIGRVPN
G
KN
LD
A
GKA
GVE
V
DDRG
F
I
R
VD
KQL
RTN
V
PHI
F
AIGD
I
VGQPMLAHK
G
VH
EG
H
VAAE
V
I
--
AG
K
K
H
YF
DP
---
KV
IPS
I
A
YT
E
PEVAWVG
L
TE
KE
AK
E
K
GI
S
YE
T
A
T
FP
W
A
AS
GRA
I
A
S
D
CAD
G
MT
KLIFDKES
H
RVIGGAIVG
TN
G
GEL
L
G
EI
G
LAIE
M
---
G
C
D
A
EDIA
L
TIHAHPTL
H
E
SVG
LAAEVFEGSITDLPNPKAKKK
fig|562.372.peg.2996
Escherichia coli 1212A (13-495/495)
AGDKYIEVMMSTEIKTQV
V
V
L
G
A
GPAGY
S
AA
F
R
C
AD
L
GL
ET
VI
V
------
ERY
N
TLGG
V
CLNVGCIPSKALLH
V
A
KV
I
E
E
AKAL
A
E
-
HG
IVFGE
P
KT
D
I
D
K
I
R
TW
K
E
K
VINQL
-
T
G
G
LA
G
MA
KG
R
K
-
VKV
V
N
GL
GK
F
T
G
A
N
----
TL
E
VE
-
G
EN
G
KT
VI
N
FDN
A
I
IA
A
GSRP
I
--
QLP
F
I
PHE
DPRIWDST
D
AL
E
L
KE
VPERLLV
M
G
G
G
I
IGLE
M
G
T
V
Y
HA
LGS
QI
D
V
VEM
F
D
QV
I
PA
A
D
KD
I
V
-K
V
FTK
R
IS
KK
FN
L
M
L
E
T
K
V
T
AVE
AK
E
---
DG
I
Y
V
T
-
ME
GKK
AP
A
E
PQ
R
Y
--
D
A
V
LVAIGRVPN
G
KN
LD
A
GKA
GVE
V
DDRG
F
I
R
VD
KQL
RTN
V
PHI
F
AIGD
I
VGQPMLAHK
G
VH
EG
H
VAAE
V
I
--
AG
K
K
H
YF
DP
---
KV
IPS
I
A
YT
E
PEVAWVG
L
TE
KE
AK
E
K
GI
S
YE
T
A
T
FP
W
A
AS
GRA
I
A
S
D
CAD
G
MT
KLIFDKES
H
RVIGGAIVG
TN
G
GEL
L
G
EI
G
LAIE
M
---
G
C
D
A
EDIA
L
TIHAHPTL
H
E
SVG
LAAEVFEGSITDLPNPKAKKK
fig|362663.8.peg.126
Escherichia coli 536 (13-495/495)
AGDKYIEVMMSTEIKTQV
V
V
L
G
A
GPAGY
S
AA
F
R
C
AD
L
GL
ET
VI
V
------
ERY
N
TLGG
V
CLNVGCIPSKALLH
V
A
KV
I
E
E
AKAL
A
E
-
HG
IVFGE
P
KT
D
I
D
K
I
R
TW
K
E
K
VINQL
-
T
G
G
LA
G
MA
KG
R
K
-
VKV
V
N
GL
GK
F
T
G
A
N
----
TL
E
VE
-
G
EN
G
KT
VI
N
FDN
A
I
IA
A
GSRP
I
--
QLP
F
I
PHE
DPRIWDST
D
AL
E
L
KE
VPERLLV
M
G
G
G
I
IGLE
M
G
T
V
Y
HA
LGS
QI
D
V
VEM
F
D
QV
I
PA
A
D
KD
I
V
-K
V
FTK
R
IS
KK
FN
L
M
L
E
T
K
V
T
AVE
AK
E
---
DG
I
Y
V
T
-
ME
GKK
AP
A
E
PQ
R
Y
--
D
A
V
LVAIGRVPN
G
KN
LD
A
GKA
GVE
V
DDRG
F
I
R
VD
KQL
RTN
V
PHI
F
AIGD
I
VGQPMLAHK
G
VH
EG
H
VAAE
V
I
--
AG
K
K
H
YF
DP
---
KV
IPS
I
A
YT
E
PEVAWVG
L
TE
KE
AK
E
K
GI
S
YE
T
A
T
FP
W
A
AS
GRA
I
A
S
D
CAD
G
MT
KLIFDKES
H
RVIGGAIVG
TN
G
GEL
L
G
EI
G
LAIE
M
---
G
C
D
A
EDIA
L
TIHAHPTL
H
E
SVG
LAAEVFEGSITDLPNPKAKKK
fig|362663.9.peg.126
Escherichia coli 536 (13-495/495)
AGDKYIEVMMSTEIKTQV
V
V
L
G
A
GPAGY
S
AA
F
R
C
AD
L
GL
ET
VI
V
------
ERY
N
TLGG
V
CLNVGCIPSKALLH
V
A
KV
I
E
E
AKAL
A
E
-
HG
IVFGE
P
KT
D
I
D
K
I
R
TW
K
E
K
VINQL
-
T
G
G
LA
G
MA
KG
R
K
-
VKV
V
N
GL
GK
F
T
G
A
N
----
TL
E
VE
-
G
EN
G
KT
VI
N
FDN
A
I
IA
A
GSRP
I
--
QLP
F
I
PHE
DPRIWDST
D
AL
E
L
KE
VPERLLV
M
G
G
G
I
IGLE
M
G
T
V
Y
HA
LGS
QI
D
V
VEM
F
D
QV
I
PA
A
D
KD
I
V
-K
V
FTK
R
IS
KK
FN
L
M
L
E
T
K
V
T
AVE
AK
E
---
DG
I
Y
V
T
-
ME
GKK
AP
A
E
PQ
R
Y
--
D
A
V
LVAIGRVPN
G
KN
LD
A
GKA
GVE
V
DDRG
F
I
R
VD
KQL
RTN
V
PHI
F
AIGD
I
VGQPMLAHK
G
VH
EG
H
VAAE
V
I
--
AG
K
K
H
YF
DP
---
KV
IPS
I
A
YT
E
PEVAWVG
L
TE
KE
AK
E
K
GI
S
YE
T
A
T
FP
W
A
AS
GRA
I
A
S
D
CAD
G
MT
KLIFDKES
H
RVIGGAIVG
TN
G
GEL
L
G
EI
G
LAIE
M
---
G
C
D
A
EDIA
L
TIHAHPTL
H
E
SVG
LAAEVFEGSITDLPNPKAKKK
fig|562.374.peg.2187
Escherichia coli 536A (13-495/495)
AGDKYIEVMMSTEIKTQV
V
V
L
G
A
GPAGY
S
AA
F
R
C
AD
L
GL
ET
VI
V
------
ERY
N
TLGG
V
CLNVGCIPSKALLH
V
A
KV
I
E
E
AKAL
A
E
-
HG
IVFGE
P
KT
D
I
D
K
I
R
TW
K
E
K
VINQL
-
T
G
G
LA
G
MA
KG
R
K
-
VKV
V
N
GL
GK
F
T
G
A
N
----
TL
E
VE
-
G
EN
G
KT
VI
N
FDN
A
I
IA
A
GSRP
I
--
QLP
F
I
PHE
DPRIWDST
D
AL
E
L
KE
VPERLLV
M
G
G
G
I
IGLE
M
G
T
V
Y
HA
LGS
QI
D
V
VEM
F
D
QV
I
PA
A
D
KD
I
V
-K
V
FTK
R
IS
KK
FN
L
M
L
E
T
K
V
T
AVE
AK
E
---
DG
I
Y
V
T
-
ME
GKK
AP
A
E
PQ
R
Y
--
D
A
V
LVAIGRVPN
G
KN
LD
A
GKA
GVE
V
DDRG
F
I
R
VD
KQL
RTN
V
PHI
F
AIGD
I
VGQPMLAHK
G
VH
EG
H
VAAE
V
I
--
AG
K
K
H
YF
DP
---
KV
IPS
I
A
YT
E
PEVAWVG
L
TE
KE
AK
E
K
GI
S
YE
T
A
T
FP
W
A
AS
GRA
I
A
S
D
CAD
G
MT
KLIFDKES
H
RVIGGAIVG
TN
G
GEL
L
G
EI
G
LAIE
M
---
G
C
D
A
EDIA
L
TIHAHPTL
H
E
SVG
LAAEVFEGSITDLPNPKAKKK
fig|525281.3.peg.1148
Escherichia coli 83972 (13-495/495)
AGDKYIEVMMSTEIKTQV
V
V
L
G
A
GPAGY
S
AA
F
R
C
AD
L
GL
ET
VI
V
------
ERY
N
TLGG
V
CLNVGCIPSKALLH
V
A
KV
I
E
E
AKAL
A
E
-
HG
IVFGE
P
KT
D
I
D
K
I
R
TW
K
E
K
VINQL
-
T
G
G
LA
G
MA
KG
R
K
-
VKV
V
N
GL
GK
F
T
G
A
N
----
TL
E
VE
-
G
EN
G
KT
VI
N
FDN
A
I
IA
A
GSRP
I
--
QLP
F
I
PHE
DPRIWDST
D
AL
E
L
KE
VPERLLV
M
G
G
G
I
IGLE
M
G
T
V
Y
HA
LGS
QI
D
V
VEM
F
D
QV
I
PA
A
D
KD
I
V
-K
V
FTK
R
IS
KK
FN
L
M
L
E
T
K
V
T
AVE
AK
E
---
DG
I
Y
V
T
-
ME
GKK
AP
A
E
PQ
R
Y
--
D
A
V
LVAIGRVPN
G
KN
LD
A
GKA
GVE
V
DDRG
F
I
R
VD
KQL
RTN
V
PHI
F
AIGD
I
VGQPMLAHK
G
VH
EG
H
VAAE
V
I
--
AG
K
K
H
YF
DP
---
KV
IPS
I
A
YT
E
PEVAWVG
L
TE
KE
AK
E
K
GI
S
YE
T
A
T
FP
W
A
AS
GRA
I
A
S
D
CAD
G
MT
KLIFDKES
H
RVIGGAIVG
TN
G
GEL
L
G
EI
G
LAIE
M
---
G
C
D
A
EDIA
L
TIHAHPTL
H
E
SVG
LAAEVFEGSITDLPNPKAKKK
fig|655817.3.peg.139
Escherichia coli ABU 83972 (13-495/495)
AGDKYIEVMMSTEIKTQV
V
V
L
G
A
GPAGY
S
AA
F
R
C
AD
L
GL
ET
VI
V
------
ERY
N
TLGG
V
CLNVGCIPSKALLH
V
A
KV
I
E
E
AKAL
A
E
-
HG
IVFGE
P
KT
D
I
D
K
I
R
TW
K
E
K
VINQL
-
T
G
G
LA
G
MA
KG
R
K
-
VKV
V
N
GL
GK
F
T
G
A
N
----
TL
E
VE
-
G
EN
G
KT
VI
N
FDN
A
I
IA
A
GSRP
I
--
QLP
F
I
PHE
DPRIWDST
D
AL
E
L
KE
VPERLLV
M
G
G
G
I
IGLE
M
G
T
V
Y
HA
LGS
QI
D
V
VEM
F
D
QV
I
PA
A
D
KD
I
V
-K
V
FTK
R
IS
KK
FN
L
M
L
E
T
K
V
T
AVE
AK
E
---
DG
I
Y
V
T
-
ME
GKK
AP
A
E
PQ
R
Y
--
D
A
V
LVAIGRVPN
G
KN
LD
A
GKA
GVE
V
DDRG
F
I
R
VD
KQL
RTN
V
PHI
F
AIGD
I
VGQPMLAHK
G
VH
EG
H
VAAE
V
I
--
AG
K
K
H
YF
DP
---
KV
IPS
I
A
YT
E
PEVAWVG
L
TE
KE
AK
E
K
GI
S
YE
T
A
T
FP
W
A
AS
GRA
I
A
S
D
CAD
G
MT
KLIFDKES
H
RVIGGAIVG
TN
G
GEL
L
G
EI
G
LAIE
M
---
G
C
D
A
EDIA
L
TIHAHPTL
H
E
SVG
LAAEVFEGSITDLPNPKAKKK
fig|550676.3.peg.4783
Escherichia coli B185 (13-495/495)
AGDKYIEVMMSTEIKTQV
V
V
L
G
A
GPAGY
S
AA
F
R
C
AD
L
GL
ET
VI
V
------
ERY
N
TLGG
V
CLNVGCIPSKALLH
V
A
KV
I
E
E
AKAL
A
E
-
HG
IVFGE
P
KT
D
I
D
K
I
R
TW
K
E
K
VINQL
-
T
G
G
LA
G
MA
KG
R
K
-
VKV
V
N
GL
GK
F
T
G
A
N
----
TL
E
VE
-
G
EN
G
KT
VI
N
FDN
A
I
IA
A
GSRP
I
--
QLP
F
I
PHE
DPRIWDST
D
AL
E
L
KE
VPERLLV
M
G
G
G
I
IGLE
M
G
T
V
Y
HA
LGS
QI
D
V
VEM
F
D
QV
I
PA
A
D
KD
I
V
-K
V
FTK
R
IS
KK
FN
L
M
L
E
T
K
V
T
AVE
AK
E
---
DG
I
Y
V
T
-
ME
GKK
AP
A
E
PQ
R
Y
--
D
A
V
LVAIGRVPN
G
KN
LD
A
GKA
GVE
V
DDRG
F
I
R
VD
KQL
RTN
V
PHI
F
AIGD
I
VGQPMLAHK
G
VH
EG
H
VAAE
V
I
--
AG
K
K
H
YF
DP
---
KV
IPS
I
A
YT
E
PEVAWVG
L
TE
KE
AK
E
K
GI
S
YE
T
A
T
FP
W
A
AS
GRA
I
A
S
D
CAD
G
MT
KLIFDKES
H
RVIGGAIVG
TN
G
GEL
L
G
EI
G
LAIE
M
---
G
C
D
A
EDIA
L
TIHAHPTL
H
E
SVG
LAAEVFEGSITDLPNPKAKKK
fig|199310.1.peg.139
Escherichia coli CFT073 (13-495/495)
AGDKYIEVMMSTEIKTQV
V
V
L
G
A
GPAGY
S
AA
F
R
C
AD
L
GL
ET
VI
V
------
ERY
N
TLGG
V
CLNVGCIPSKALLH
V
A
KV
I
E
E
AKAL
A
E
-
HG
IVFGE
P
KT
D
I
D
K
I
R
TW
K
E
K
VINQL
-
T
G
G
LA
G
MA
KG
R
K
-
VKV
V
N
GL
GK
F
T
G
A
N
----
TL
E
VE
-
G
EN
G
KT
VI
N
FDN
A
I
IA
A
GSRP
I
--
QLP
F
I
PHE
DPRIWDST
D
AL
E
L
KE
VPERLLV
M
G
G
G
I
IGLE
M
G
T
V
Y
HA
LGS
QI
D
V
VEM
F
D
QV
I
PA
A
D
KD
I
V
-K
V
FTK
R
IS
KK
FN
L
M
L
E
T
K
V
T
AVE
AK
E
---
DG
I
Y
V
T
-
ME
GKK
AP
A
E
PQ
R
Y
--
D
A
V
LVAIGRVPN
G
KN
LD
A
GKA
GVE
V
DDRG
F
I
R
VD
KQL
RTN
V
PHI
F
AIGD
I
VGQPMLAHK
G
VH
EG
H
VAAE
V
I
--
AG
K
K
H
YF
DP
---
KV
IPS
I
A
YT
E
PEVAWVG
L
TE
KE
AK
E
K
GI
S
YE
T
A
T
FP
W
A
AS
GRA
I
A
S
D
CAD
G
MT
KLIFDKES
H
RVIGGAIVG
TN
G
GEL
L
G
EI
G
LAIE
M
---
G
C
D
A
EDIA
L
TIHAHPTL
H
E
SVG
LAAEVFEGSITDLPNPKAKKK
fig|199310.4.peg.138
Escherichia coli CFT073 (13-495/495)
AGDKYIEVMMSTEIKTQV
V
V
L
G
A
GPAGY
S
AA
F
R
C
AD
L
GL
ET
VI
V
------
ERY
N
TLGG
V
CLNVGCIPSKALLH
V
A
KV
I
E
E
AKAL
A
E
-
HG
IVFGE
P
KT
D
I
D
K
I
R
TW
K
E
K
VINQL
-
T
G
G
LA
G
MA
KG
R
K
-
VKV
V
N
GL
GK
F
T
G
A
N
----
TL
E
VE
-
G
EN
G
KT
VI
N
FDN
A
I
IA
A
GSRP
I
--
QLP
F
I
PHE
DPRIWDST
D
AL
E
L
KE
VPERLLV
M
G
G
G
I
IGLE
M
G
T
V
Y
HA
LGS
QI
D
V
VEM
F
D
QV
I
PA
A
D
KD
I
V
-K
V
FTK
R
IS
KK
FN
L
M
L
E
T
K
V
T
AVE
AK
E
---
DG
I
Y
V
T
-
ME
GKK
AP
A
E
PQ
R
Y
--
D
A
V
LVAIGRVPN
G
KN
LD
A
GKA
GVE
V
DDRG
F
I
R
VD
KQL
RTN
V
PHI
F
AIGD
I
VGQPMLAHK
G
VH
EG
H
VAAE
V
I
--
AG
K
K
H
YF
DP
---
KV
IPS
I
A
YT
E
PEVAWVG
L
TE
KE
AK
E
K
GI
S
YE
T
A
T
FP
W
A
AS
GRA
I
A
S
D
CAD
G
MT
KLIFDKES
H
RVIGGAIVG
TN
G
GEL
L
G
EI
G
LAIE
M
---
G
C
D
A
EDIA
L
TIHAHPTL
H
E
SVG
LAAEVFEGSITDLPNPKAKKK
fig|216593.1.peg.3457
Escherichia coli E2348/69 (13-495/495)
AGDKYIEVMMSTEIKTQV
V
V
L
G
A
GPAGY
S
AA
F
R
C
AD
L
GL
ET
VI
V
------
ERY
N
TLGG
V
CLNVGCIPSKALLH
V
A
KV
I
E
E
AKAL
A
E
-
HG
IVFGE
P
KT
D
I
D
K
I
R
TW
K
E
K
VINQL
-
T
G
G
LA
G
MA
KG
R
K
-
VKV
V
N
GL
GK
F
T
G
A
N
----
TL
E
VE
-
G
EN
G
KT
VI
N
FDN
A
I
IA
A
GSRP
I
--
QLP
F
I
PHE
DPRIWDST
D
AL
E
L
KE
VPERLLV
M
G
G
G
I
IGLE
M
G
T
V
Y
HA
LGS
QI
D
V
VEM
F
D
QV
I
PA
A
D
KD
I
V
-K
V
FTK
R
IS
KK
FN
L
M
L
E
T
K
V
T
AVE
AK
E
---
DG
I
Y
V
T
-
ME
GKK
AP
A
E
PQ
R
Y
--
D
A
V
LVAIGRVPN
G
KN
LD
A
GKA
GVE
V
DDRG
F
I
R
VD
KQL
RTN
V
PHI
F
AIGD
I
VGQPMLAHK
G
VH
EG
H
VAAE
V
I
--
AG
K
K
H
YF
DP
---
KV
IPS
I
A
YT
E
PEVAWVG
L
TE
KE
AK
E
K
GI
S
YE
T
A
T
FP
W
A
AS
GRA
I
A
S
D
CAD
G
MT
KLIFDKES
H
RVIGGAIVG
TN
G
GEL
L
G
EI
G
LAIE
M
---
G
C
D
A
EDIA
L
TIHAHPTL
H
E
SVG
LAAEVFEGSITDLPNPKAKKK
fig|585397.7.peg.126
Escherichia coli ED1a (13-495/495)
AGDKYIEVMMSTEIKTQV
V
V
L
G
A
GPAGY
S
AA
F
R
C
AD
L
GL
ET
VI
V
------
ERY
N
TLGG
V
CLNVGCIPSKALLH
V
A
KV
I
E
E
AKAL
A
E
-
HG
IVFGE
P
KT
D
I
D
K
I
R
TW
K
E
K
VINQL
-
T
G
G
LA
G
MA
KG
R
K
-
VKV
V
N
GL
GK
F
T
G
A
N
----
TL
E
VE
-
G
EN
G
KT
VI
N
FDN
A
I
IA
A
GSRP
I
--
QLP
F
I
PHE
DPRIWDST
D
AL
E
L
KE
VPERLLV
M
G
G
G
I
IGLE
M
G
T
V
Y
HA
LGS
QI
D
V
VEM
F
D
QV
I
PA
A
D
KD
I
V
-K
V
FTK
R
IS
KK
FN
L
M
L
E
T
K
V
T
AVE
AK
E
---
DG
I
Y
V
T
-
ME
GKK
AP
A
E
PQ
R
Y
--
D
A
V
LVAIGRVPN
G
KN
LD
A
GKA
GVE
V
DDRG
F
I
R
VD
KQL
RTN
V
PHI
F
AIGD
I
VGQPMLAHK
G
VH
EG
H
VAAE
V
I
--
AG
K
K
H
YF
DP
---
KV
IPS
I
A
YT
E
PEVAWVG
L
TE
KE
AK
E
K
GI
S
YE
T
A
T
FP
W
A
AS
GRA
I
A
S
D
CAD
G
MT
KLIFDKES
H
RVIGGAIVG
TN
G
GEL
L
G
EI
G
LAIE
M
---
G
C
D
A
EDIA
L
TIHAHPTL
H
E
SVG
LAAEVFEGSITDLPNPKAKKK
fig|585397.9.peg.126
Escherichia coli ED1a (13-495/495)
AGDKYIEVMMSTEIKTQV
V
V
L
G
A
GPAGY
S
AA
F
R
C
AD
L
GL
ET
VI
V
------
ERY
N
TLGG
V
CLNVGCIPSKALLH
V
A
KV
I
E
E
AKAL
A
E
-
HG
IVFGE
P
KT
D
I
D
K
I
R
TW
K
E
K
VINQL
-
T
G
G
LA
G
MA
KG
R
K
-
VKV
V
N
GL
GK
F
T
G
A
N
----
TL
E
VE
-
G
EN
G
KT
VI
N
FDN
A
I
IA
A
GSRP
I
--
QLP
F
I
PHE
DPRIWDST
D
AL
E
L
KE
VPERLLV
M
G
G
G
I
IGLE
M
G
T
V
Y
HA
LGS
QI
D
V
VEM
F
D
QV
I
PA
A
D
KD
I
V
-K
V
FTK
R
IS
KK
FN
L
M
L
E
T
K
V
T
AVE
AK
E
---
DG
I
Y
V
T
-
ME
GKK
AP
A
E
PQ
R
Y
--
D
A
V
LVAIGRVPN
G
KN
LD
A
GKA
GVE
V
DDRG
F
I
R
VD
KQL
RTN
V
PHI
F
AIGD
I
VGQPMLAHK
G
VH
EG
H
VAAE
V
I
--
AG
K
K
H
YF
DP
---
KV
IPS
I
A
YT
E
PEVAWVG
L
TE
KE
AK
E
K
GI
S
YE
T
A
T
FP
W
A
AS
GRA
I
A
S
D
CAD
G
MT
KLIFDKES
H
RVIGGAIVG
TN
G
GEL
L
G
EI
G
LAIE
M
---
G
C
D
A
EDIA
L
TIHAHPTL
H
E
SVG
LAAEVFEGSITDLPNPKAKKK
fig|340197.5.peg.4575
Escherichia coli F11 (13-495/495)
AGDKYIEVMMSTEIKTQV
V
V
L
G
A
GPAGY
S
AA
F
R
C
AD
L
GL
ET
VI
V
------
ERY
N
TLGG
V
CLNVGCIPSKALLH
V
A
KV
I
E
E
AKAL
A
E
-
HG
IVFGE
P
KT
D
I
D
K
I
R
TW
K
E
K
VINQL
-
T
G
G
LA
G
MA
KG
R
K
-
VKV
V
N
GL
GK
F
T
G
A
N
----
TL
E
VE
-
G
EN
G
KT
VI
N
FDN
A
I
IA
A
GSRP
I
--
QLP
F
I
PHE
DPRIWDST
D
AL
E
L
KE
VPERLLV
M
G
G
G
I
IGLE
M
G
T
V
Y
HA
LGS
QI
D
V
VEM
F
D
QV
I
PA
A
D
KD
I
V
-K
V
FTK
R
IS
KK
FN
L
M
L
E
T
K
V
T
AVE
AK
E
---
DG
I
Y
V
T
-
ME
GKK
AP
A
E
PQ
R
Y
--
D
A
V
LVAIGRVPN
G
KN
LD
A
GKA
GVE
V
DDRG
F
I
R
VD
KQL
RTN
V
PHI
F
AIGD
I
VGQPMLAHK
G
VH
EG
H
VAAE
V
I
--
AG
K
K
H
YF
DP
---
KV
IPS
I
A
YT
E
PEVAWVG
L
TE
KE
AK
E
K
GI
S
YE
T
A
T
FP
W
A
AS
GRA
I
A
S
D
CAD
G
MT
KLIFDKES
H
RVIGGAIVG
TN
G
GEL
L
G
EI
G
LAIE
M
---
G
C
D
A
EDIA
L
TIHAHPTL
H
E
SVG
LAAEVFEGSITDLPNPKAKKK
fig|714962.3.peg.125
Escherichia coli IHE3034 (13-495/495)
AGDKYIEVMMSTEIKTQV
V
V
L
G
A
GPAGY
S
AA
F
R
C
AD
L
GL
ET
VI
V
------
ERY
N
TLGG
V
CLNVGCIPSKALLH
V
A
KV
I
E
E
AKAL
A
E
-
HG
IVFGE
P
KT
D
I
D
K
I
R
TW
K
E
K
VINQL
-
T
G
G
LA
G
MA
KG
R
K
-
VKV
V
N
GL
GK
F
T
G
A
N
----
TL
E
VE
-
G
EN
G
KT
VI
N
FDN
A
I
IA
A
GSRP
I
--
QLP
F
I
PHE
DPRIWDST
D
AL
E
L
KE
VPERLLV
M
G
G
G
I
IGLE
M
G
T
V
Y
HA
LGS
QI
D
V
VEM
F
D
QV
I
PA
A
D
KD
I
V
-K
V
FTK
R
IS
KK
FN
L
M
L
E
T
K
V
T
AVE
AK
E
---
DG
I
Y
V
T
-
ME
GKK
AP
A
E
PQ
R
Y
--
D
A
V
LVAIGRVPN
G
KN
LD
A
GKA
GVE
V
DDRG
F
I
R
VD
KQL
RTN
V
PHI
F
AIGD
I
VGQPMLAHK
G
VH
EG
H
VAAE
V
I
--
AG
K
K
H
YF
DP
---
KV
IPS
I
A
YT
E
PEVAWVG
L
TE
KE
AK
E
K
GI
S
YE
T
A
T
FP
W
A
AS
GRA
I
A
S
D
CAD
G
MT
KLIFDKES
H
RVIGGAIVG
TN
G
GEL
L
G
EI
G
LAIE
M
---
G
C
D
A
EDIA
L
TIHAHPTL
H
E
SVG
LAAEVFEGSITDLPNPKAKKK
fig|656417.3.peg.189
Escherichia coli M605 (13-495/495)
AGDKYIEVMMSTEIKTQV
V
V
L
G
A
GPAGY
S
AA
F
R
C
AD
L
GL
ET
VI
V
------
ERY
N
TLGG
V
CLNVGCIPSKALLH
V
A
KV
I
E
E
AKAL
A
E
-
HG
IVFGE
P
KT
D
I
D
K
I
R
TW
K
E
K
VINQL
-
T
G
G
LA
G
MA
KG
R
K
-
VKV
V
N
GL
GK
F
T
G
A
N
----
TL
E
VE
-
G
EN
G
KT
VI
N
FDN
A
I
IA
A
GSRP
I
--
QLP
F
I
PHE
DPRIWDST
D
AL
E
L
KE
VPERLLV
M
G
G
G
I
IGLE
M
G
T
V
Y
HA
LGS
QI
D
V
VEM
F
D
QV
I
PA
A
D
KD
I
V
-K
V
FTK
R
IS
KK
FN
L
M
L
E
T
K
V
T
AVE
AK
E
---
DG
I
Y
V
T
-
ME
GKK
AP
A
E
PQ
R
Y
--
D
A
V
LVAIGRVPN
G
KN
LD
A
GKA
GVE
V
DDRG
F
I
R
VD
KQL
RTN
V
PHI
F
AIGD
I
VGQPMLAHK
G
VH
EG
H
VAAE
V
I
--
AG
K
K
H
YF
DP
---
KV
IPS
I
A
YT
E
PEVAWVG
L
TE
KE
AK
E
K
GI
S
YE
T
A
T
FP
W
A
AS
GRA
I
A
S
D
CAD
G
MT
KLIFDKES
H
RVIGGAIVG
TN
G
GEL
L
G
EI
G
LAIE
M
---
G
C
D
A
EDIA
L
TIHAHPTL
H
E
SVG
LAAEVFEGSITDLPNPKAKKK
fig|656419.3.peg.281
Escherichia coli M718 (13-495/495)
AGDKYIEVMMSTEIKTQV
V
V
L
G
A
GPAGY
S
AA
F
R
C
AD
L
GL
ET
VI
V
------
ERY
N
TLGG
V
CLNVGCIPSKALLH
V
A
KV
I
E
E
AKAL
A
E
-
HG
IVFGE
P
KT
D
I
D
K
I
R
TW
K
E
K
VINQL
-
T
G
G
LA
G
MA
KG
R
K
-
VKV
V
N
GL
GK
F
T
G
A
N
----
TL
E
VE
-
G
EN
G
KT
VI
N
FDN
A
I
IA
A
GSRP
I
--
QLP
F
I
PHE
DPRIWDST
D
AL
E
L
KE
VPERLLV
M
G
G
G
I
IGLE
M
G
T
V
Y
HA
LGS
QI
D
V
VEM
F
D
QV
I
PA
A
D
KD
I
V
-K
V
FTK
R
IS
KK
FN
L
M
L
E
T
K
V
T
AVE
AK
E
---
DG
I
Y
V
T
-
ME
GKK
AP
A
E
PQ
R
Y
--
D
A
V
LVAIGRVPN
G
KN
LD
A
GKA
GVE
V
DDRG
F
I
R
VD
KQL
RTN
V
PHI
F
AIGD
I
VGQPMLAHK
G
VH
EG
H
VAAE
V
I
--
AG
K
K
H
YF
DP
---
KV
IPS
I
A
YT
E
PEVAWVG
L
TE
KE
AK
E
K
GI
S
YE
T
A
T
FP
W
A
AS
GRA
I
A
S
D
CAD
G
MT
KLIFDKES
H
RVIGGAIVG
TN
G
GEL
L
G
EI
G
LAIE
M
---
G
C
D
A
EDIA
L
TIHAHPTL
H
E
SVG
LAAEVFEGSITDLPNPKAKKK
fig|679205.4.peg.2295
Escherichia coli MS 124-1 (13-495/495)
AGDKYIEVMMSTEIKTQV
V
V
L
G
A
GPAGY
S
AA
F
R
C
AD
L
GL
ET
VI
V
------
ERY
N
TLGG
V
CLNVGCIPSKALLH
V
A
KV
I
E
E
AKAL
A
E
-
HG
IVFGE
P
KT
D
I
D
K
I
R
TW
K
E
K
VINQL
-
T
G
G
LA
G
MA
KG
R
K
-
VKV
V
N
GL
GK
F
T
G
A
N
----
TL
E
VE
-
G
EN
G
KT
VI
N
FDN
A
I
IA
A
GSRP
I
--
QLP
F
I
PHE
DPRIWDST
D
AL
E
L
KE
VPERLLV
M
G
G
G
I
IGLE
M
G
T
V
Y
HA
LGS
QI
D
V
VEM
F
D
QV
I
PA
A
D
KD
I
V
-K
V
FTK
R
IS
KK
FN
L
M
L
E
T
K
V
T
AVE
AK
E
---
DG
I
Y
V
T
-
ME
GKK
AP
A
E
PQ
R
Y
--
D
A
V
LVAIGRVPN
G
KN
LD
A
GKA
GVE
V
DDRG
F
I
R
VD
KQL
RTN
V
PHI
F
AIGD
I
VGQPMLAHK
G
VH
EG
H
VAAE
V
I
--
AG
K
K
H
YF
DP
---
KV
IPS
I
A
YT
E
PEVAWVG
L
TE
KE
AK
E
K
GI
S
YE
T
A
T
FP
W
A
AS
GRA
I
A
S
D
CAD
G
MT
KLIFDKES
H
RVIGGAIVG
TN
G
GEL
L
G
EI
G
LAIE
M
---
G
C
D
A
EDIA
L
TIHAHPTL
H
E
SVG
LAAEVFEGSITDLPNPKAKKK
fig|749546.3.peg.3676
Escherichia coli MS 185-1 (13-495/495)
AGDKYIEVMMSTEIKTQV
V
V
L
G
A
GPAGY
S
AA
F
R
C
AD
L
GL
ET
VI
V
------
ERY
N
TLGG
V
CLNVGCIPSKALLH
V
A
KV
I
E
E
AKAL
A
E
-
HG
IVFGE
P
KT
D
I
D
K
I
R
TW
K
E
K
VINQL
-
T
G
G
LA
G
MA
KG
R
K
-
VKV
V
N
GL
GK
F
T
G
A
N
----
TL
E
VE
-
G
EN
G
KT
VI
N
FDN
A
I
IA
A
GSRP
I
--
QLP
F
I
PHE
DPRIWDST
D
AL
E
L
KE
VPERLLV
M
G
G
G
I
IGLE
M
G
T
V
Y
HA
LGS
QI
D
V
VEM
F
D
QV
I
PA
A
D
KD
I
V
-K
V
FTK
R
IS
KK
FN
L
M
L
E
T
K
V
T
AVE
AK
E
---
DG
I
Y
V
T
-
ME
GKK
AP
A
E
PQ
R
Y
--
D
A
V
LVAIGRVPN
G
KN
LD
A
GKA
GVE
V
DDRG
F
I
R
VD
KQL
RTN
V
PHI
F
AIGD
I
VGQPMLAHK
G
VH
EG
H
VAAE
V
I
--
AG
K
K
H
YF
DP
---
KV
IPS
I
A
YT
E
PEVAWVG
L
TE
KE
AK
E
K
GI
S
YE
T
A
T
FP
W
A
AS
GRA
I
A
S
D
CAD
G
MT
KLIFDKES
H
RVIGGAIVG
TN
G
GEL
L
G
EI
G
LAIE
M
---
G
C
D
A
EDIA
L
TIHAHPTL
H
E
SVG
LAAEVFEGSITDLPNPKAKKK
fig|749549.3.peg.4701
Escherichia coli MS 198-1 (13-495/495)
AGDKYIEVMMSTEIKTQV
V
V
L
G
A
GPAGY
S
AA
F
R
C
AD
L
GL
ET
VI
V
------
ERY
N
TLGG
V
CLNVGCIPSKALLH
V
A
KV
I
E
E
AKAL
A
E
-
HG
IVFGE
P
KT
D
I
D
K
I
R
TW
K
E
K
VINQL
-
T
G
G
LA
G
MA
KG
R
K
-
VKV
V
N
GL
GK
F
T
G
A
N
----
TL
E
VE
-
G
EN
G
KT
VI
N
FDN
A
I
IA
A
GSRP
I
--
QLP
F
I
PHE
DPRIWDST
D
AL
E
L
KE
VPERLLV
M
G
G
G
I
IGLE
M
G
T
V
Y
HA
LGS
QI
D
V
VEM
F
D
QV
I
PA
A
D
KD
I
V
-K
V
FTK
R
IS
KK
FN
L
M
L
E
T
K
V
T
AVE
AK
E
---
DG
I
Y
V
T
-
ME
GKK
AP
A
E
PQ
R
Y
--
D
A
V
LVAIGRVPN
G
KN
LD
A
GKA
GVE
V
DDRG
F
I
R
VD
KQL
RTN
V
PHI
F
AIGD
I
VGQPMLAHK
G
VH
EG
H
VAAE
V
I
--
AG
K
K
H
YF
DP
---
KV
IPS
I
A
YT
E
PEVAWVG
L
TE
KE
AK
E
K
GI
S
YE
T
A
T
FP
W
A
AS
GRA
I
A
S
D
CAD
G
MT
KLIFDKES
H
RVIGGAIVG
TN
G
GEL
L
G
EI
G
LAIE
M
---
G
C
D
A
EDIA
L
TIHAHPTL
H
E
SVG
LAAEVFEGSITDLPNPKAKKK
fig|749550.3.peg.2640
Escherichia coli MS 200-1 (13-495/495)
AGDKYIEVMMSTEIKTQV
V
V
L
G
A
GPAGY
S
AA
F
R
C
AD
L
GL
ET
VI
V
------
ERY
N
TLGG
V
CLNVGCIPSKALLH
V
A
KV
I
E
E
AKAL
A
E
-
HG
IVFGE
P
KT
D
I
D
K
I
R
TW
K
E
K
VINQL
-
T
G
G
LA
G
MA
KG
R
K
-
VKV
V
N
GL
GK
F
T
G
A
N
----
TL
E
VE
-
G
EN
G
KT
VI
N
FDN
A
I
IA
A
GSRP
I
--
QLP
F
I
PHE
DPRIWDST
D
AL
E
L
KE
VPERLLV
M
G
G
G
I
IGLE
M
G
T
V
Y
HA
LGS
QI
D
V
VEM
F
D
QV
I
PA
A
D
KD
I
V
-K
V
FTK
R
IS
KK
FN
L
M
L
E
T
K
V
T
AVE
AK
E
---
DG
I
Y
V
T
-
ME
GKK
AP
A
E
PQ
R
Y
--
D
A
V
LVAIGRVPN
G
KN
LD
A
GKA
GVE
V
DDRG
F
I
R
VD
KQL
RTN
V
PHI
F
AIGD
I
VGQPMLAHK
G
VH
EG
H
VAAE
V
I
--
AG
K
K
H
YF
DP
---
KV
IPS
I
A
YT
E
PEVAWVG
L
TE
KE
AK
E
K
GI
S
YE
T
A
T
FP
W
A
AS
GRA
I
A
S
D
CAD
G
MT
KLIFDKES
H
RVIGGAIVG
TN
G
GEL
L
G
EI
G
LAIE
M
---
G
C
D
A
EDIA
L
TIHAHPTL
H
E
SVG
LAAEVFEGSITDLPNPKAKKK
fig|749527.3.peg.3221
Escherichia coli MS 21-1 (13-495/495)
AGDKYIEVMMSTEIKTQV
V
V
L
G
A
GPAGY
S
AA
F
R
C
AD
L
GL
ET
VI
V
------
ERY
N
TLGG
V
CLNVGCIPSKALLH
V
A
KV
I
E
E
AKAL
A
E
-
HG
IVFGE
P
KT
D
I
D
K
I
R
TW
K
E
K
VINQL
-
T
G
G
LA
G
MA
KG
R
K
-
VKV
V
N
GL
GK
F
T
G
A
N
----
TL
E
VE
-
G
EN
G
KT
VI
N
FDN
A
I
IA
A
GSRP
I
--
QLP
F
I
PHE
DPRIWDST
D
AL
E
L
KE
VPERLLV
M
G
G
G
I
IGLE
M
G
T
V
Y
HA
LGS
QI
D
V
VEM
F
D
QV
I
PA
A
D
KD
I
V
-K
V
FTK
R
IS
KK
FN
L
M
L
E
T
K
V
T
AVE
AK
E
---
DG
I
Y
V
T
-
ME
GKK
AP
A
E
PQ
R
Y
--
D
A
V
LVAIGRVPN
G
KN
LD
A
GKA
GVE
V
DDRG
F
I
R
VD
KQL
RTN
V
PHI
F
AIGD
I
VGQPMLAHK
G
VH
EG
H
VAAE
V
I
--
AG
K
K
H
YF
DP
---
KV
IPS
I
A
YT
E
PEVAWVG
L
TE
KE
AK
E
K
GI
S
YE
T
A
T
FP
W
A
AS
GRA
I
A
S
D
CAD
G
MT
KLIFDKES
H
RVIGGAIVG
TN
G
GEL
L
G
EI
G
LAIE
M
---
G
C
D
A
EDIA
L
TIHAHPTL
H
E
SVG
LAAEVFEGSITDLPNPKAKKK
fig|749528.3.peg.4701
Escherichia coli MS 45-1 (13-495/495)
AGDKYIEVMMSTEIKTQV
V
V
L
G
A
GPAGY
S
AA
F
R
C
AD
L
GL
ET
VI
V
------
ERY
N
TLGG
V
CLNVGCIPSKALLH
V
A
KV
I
E
E
AKAL
A
E
-
HG
IVFGE
P
KT
D
I
D
K
I
R
TW
K
E
K
VINQL
-
T
G
G
LA
G
MA
KG
R
K
-
VKV
V
N
GL
GK
F
T
G
A
N
----
TL
E
VE
-
G
EN
G
KT
VI
N
FDN
A
I
IA
A
GSRP
I
--
QLP
F
I
PHE
DPRIWDST
D
AL
E
L
KE
VPERLLV
M
G
G
G
I
IGLE
M
G
T
V
Y
HA
LGS
QI
D
V
VEM
F
D
QV
I
PA
A
D
KD
I
V
-K
V
FTK
R
IS
KK
FN
L
M
L
E
T
K
V
T
AVE
AK
E
---
DG
I
Y
V
T
-
ME
GKK
AP
A
E
PQ
R
Y
--
D
A
V
LVAIGRVPN
G
KN
LD
A
GKA
GVE
V
DDRG
F
I
R
VD
KQL
RTN
V
PHI
F
AIGD
I
VGQPMLAHK
G
VH
EG
H
VAAE
V
I
--
AG
K
K
H
YF
DP
---
KV
IPS
I
A
YT
E
PEVAWVG
L
TE
KE
AK
E
K
GI
S
YE
T
A
T
FP
W
A
AS
GRA
I
A
S
D
CAD
G
MT
KLIFDKES
H
RVIGGAIVG
TN
G
GEL
L
G
EI
G
LAIE
M
---
G
C
D
A
EDIA
L
TIHAHPTL
H
E
SVG
LAAEVFEGSITDLPNPKAKKK
fig|749533.3.peg.3141
Escherichia coli MS 84-1 (13-495/495)
AGDKYIEVMMSTEIKTQV
V
V
L
G
A
GPAGY
S
AA
F
R
C
AD
L
GL
ET
VI
V
------
ERY
N
TLGG
V
CLNVGCIPSKALLH
V
A
KV
I
E
E
AKAL
A
E
-
HG
IVFGE
P
KT
D
I
D
K
I
R
TW
K
E
K
VINQL
-
T
G
G
LA
G
MA
KG
R
K
-
VKV
V
N
GL
GK
F
T
G
A
N
----
TL
E
VE
-
G
EN
G
KT
VI
N
FDN
A
I
IA
A
GSRP
I
--
QLP
F
I
PHE
DPRIWDST
D
AL
E
L
KE
VPERLLV
M
G
G
G
I
IGLE
M
G
T
V
Y
HA
LGS
QI
D
V
VEM
F
D
QV
I
PA
A
D
KD
I
V
-K
V
FTK
R
IS
KK
FN
L
M
L
E
T
K
V
T
AVE
AK
E
---
DG
I
Y
V
T
-
ME
GKK
AP
A
E
PQ
R
Y
--
D
A
V
LVAIGRVPN
G
KN
LD
A
GKA
GVE
V
DDRG
F
I
R
VD
KQL
RTN
V
PHI
F
AIGD
I
VGQPMLAHK
G
VH
EG
H
VAAE
V
I
--
AG
K
K
H
YF
DP
---
KV
IPS
I
A
YT
E
PEVAWVG
L
TE
KE
AK
E
K
GI
S
YE
T
A
T
FP
W
A
AS
GRA
I
A
S
D
CAD
G
MT
KLIFDKES
H
RVIGGAIVG
TN
G
GEL
L
G
EI
G
LAIE
M
---
G
C
D
A
EDIA
L
TIHAHPTL
H
E
SVG
LAAEVFEGSITDLPNPKAKKK
fig|753642.3.peg.3508
Escherichia coli NC101 (13-495/495)
AGDKYIEVMMSTEIKTQV
V
V
L
G
A
GPAGY
S
AA
F
R
C
AD
L
GL
ET
VI
V
------
ERY
N
TLGG
V
CLNVGCIPSKALLH
V
A
KV
I
E
E
AKAL
A
E
-
HG
IVFGE
P
KT
D
I
D
K
I
R
TW
K
E
K
VINQL
-
T
G
G
LA
G
MA
KG
R
K
-
VKV
V
N
GL
GK
F
T
G
A
N
----
TL
E
VE
-
G
EN
G
KT
VI
N
FDN
A
I
IA
A
GSRP
I
--
QLP
F
I
PHE
DPRIWDST
D
AL
E
L
KE
VPERLLV
M
G
G
G
I
IGLE
M
G
T
V
Y
HA
LGS
QI
D
V
VEM
F
D
QV
I
PA
A
D
KD
I
V
-K
V
FTK
R
IS
KK
FN
L
M
L
E
T
K
V
T
AVE
AK
E
---
DG
I
Y
V
T
-
ME
GKK
AP
A
E
PQ
R
Y
--
D
A
V
LVAIGRVPN
G
KN
LD
A
GKA
GVE
V
DDRG
F
I
R
VD
KQL
RTN
V
PHI
F
AIGD
I
VGQPMLAHK
G
VH
EG
H
VAAE
V
I
--
AG
K
K
H
YF
DP
---
KV
IPS
I
A
YT
E
PEVAWVG
L
TE
KE
AK
E
K
GI
S
YE
T
A
T
FP
W
A
AS
GRA
I
A
S
D
CAD
G
MT
KLIFDKES
H
RVIGGAIVG
TN
G
GEL
L
G
EI
G
LAIE
M
---
G
C
D
A
EDIA
L
TIHAHPTL
H
E
SVG
LAAEVFEGSITDLPNPKAKKK
fig|155864.8.peg.119
Escherichia coli O157:H7 EDL933 (13-495/495)
AGDKYIEVMMSTEIKTQV
V
V
L
G
A
GPAGY
S
AA
F
R
C
AD
L
GL
ET
VI
V
------
ERY
N
TLGG
V
CLNVGCIPSKALLH
V
A
KV
I
E
E
AKAL
A
E
-
HG
IVFGE
P
KT
D
I
D
K
I
R
TW
K
E
K
VINQL
-
T
G
G
LA
G
MA
KG
R
K
-
VKV
V
N
GL
GK
F
T
G
A
N
----
TL
E
VE
-
G
EN
G
KT
VI
N
FDN
A
I
IA
A
GSRP
I
--
QLP
F
I
PHE
DPRIWDST
D
AL
E
L
KE
VPERLLV
M
G
G
G
I
IGLE
M
G
T
V
Y
HA
LGS
QI
D
V
VEM
F
D
QV
I
PA
A
D
KD
I
V
-K
V
FTK
R
IS
KK
FN
L
M
L
E
T
K
V
T
AVE
AK
E
---
DG
I
Y
V
T
-
ME
GKK
AP
A
E
PQ
R
Y
--
D
A
V
LVAIGRVPN
G
KN
LD
A
GKA
GVE
V
DDRG
F
I
R
VD
KQL
RTN
V
PHI
F
AIGD
I
VGQPMLAHK
G
VH
EG
H
VAAE
V
I
--
AG
K
K
H
YF
DP
---
KV
IPS
I
A
YT
E
PEVAWVG
L
TE
KE
AK
E
K
GI
S
YE
T
A
T
FP
W
A
AS
GRA
I
A
S
D
CAD
G
MT
KLIFDKES
H
RVIGGAIVG
TN
G
GEL
L
G
EI
G
LAIE
M
---
G
C
D
A
EDIA
L
TIHAHPTL
H
E
SVG
LAAEVFEGSITDLPNPKAKKK
fig|444454.5.peg.4582
Escherichia coli O157:H7 str. EC4024 (13-495/495)
AGDKYIEVMMSTEIKTQV
V
V
L
G
A
GPAGY
S
AA
F
R
C
AD
L
GL
ET
VI
V
------
ERY
N
TLGG
V
CLNVGCIPSKALLH
V
A
KV
I
E
E
AKAL
A
E
-
HG
IVFGE
P
KT
D
I
D
K
I
R
TW
K
E
K
VINQL
-
T
G
G
LA
G
MA
KG
R
K
-
VKV
V
N
GL
GK
F
T
G
A
N
----
TL
E
VE
-
G
EN
G
KT
VI
N
FDN
A
I
IA
A
GSRP
I
--
QLP
F
I
PHE
DPRIWDST
D
AL
E
L
KE
VPERLLV
M
G
G
G
I
IGLE
M
G
T
V
Y
HA
LGS
QI
D
V
VEM
F
D
QV
I
PA
A
D
KD
I
V
-K
V
FTK
R
IS
KK
FN
L
M
L
E
T
K
V
T
AVE
AK
E
---
DG
I
Y
V
T
-
ME
GKK
AP
A
E
PQ
R
Y
--
D
A
V
LVAIGRVPN
G
KN
LD
A
GKA
GVE
V
DDRG
F
I
R
VD
KQL
RTN
V
PHI
F
AIGD
I
VGQPMLAHK
G
VH
EG
H
VAAE
V
I
--
AG
K
K
H
YF
DP
---
KV
IPS
I
A
YT
E
PEVAWVG
L
TE
KE
AK
E
K
GI
S
YE
T
A
T
FP
W
A
AS
GRA
I
A
S
D
CAD
G
MT
KLIFDKES
H
RVIGGAIVG
TN
G
GEL
L
G
EI
G
LAIE
M
---
G
C
D
A
EDIA
L
TIHAHPTL
H
E
SVG
LAAEVFEGSITDLPNPKAKKK
fig|444449.5.peg.4033
Escherichia coli O157:H7 str. EC4042 (13-495/495)
AGDKYIEVMMSTEIKTQV
V
V
L
G
A
GPAGY
S
AA
F
R
C
AD
L
GL
ET
VI
V
------
ERY
N
TLGG
V
CLNVGCIPSKALLH
V
A
KV
I
E
E
AKAL
A
E
-
HG
IVFGE
P
KT
D
I
D
K
I
R
TW
K
E
K
VINQL
-
T
G
G
LA
G
MA
KG
R
K
-
VKV
V
N
GL
GK
F
T
G
A
N
----
TL
E
VE
-
G
EN
G
KT
VI
N
FDN
A
I
IA
A
GSRP
I
--
QLP
F
I
PHE
DPRIWDST
D
AL
E
L
KE
VPERLLV
M
G
G
G
I
IGLE
M
G
T
V
Y
HA
LGS
QI
D
V
VEM
F
D
QV
I
PA
A
D
KD
I
V
-K
V
FTK
R
IS
KK
FN
L
M
L
E
T
K
V
T
AVE
AK
E
---
DG
I
Y
V
T
-
ME
GKK
AP
A
E
PQ
R
Y
--
D
A
V
LVAIGRVPN
G
KN
LD
A
GKA
GVE
V
DDRG
F
I
R
VD
KQL
RTN
V
PHI
F
AIGD
I
VGQPMLAHK
G
VH
EG
H
VAAE
V
I
--
AG
K
K
H
YF
DP
---
KV
IPS
I
A
YT
E
PEVAWVG
L
TE
KE
AK
E
K
GI
S
YE
T
A
T
FP
W
A
AS
GRA
I
A
S
D
CAD
G
MT
KLIFDKES
H
RVIGGAIVG
TN
G
GEL
L
G
EI
G
LAIE
M
---
G
C
D
A
EDIA
L
TIHAHPTL
H
E
SVG
LAAEVFEGSITDLPNPKAKKK
fig|444448.5.peg.2790
Escherichia coli O157:H7 str. EC4045 (13-495/495)
AGDKYIEVMMSTEIKTQV
V
V
L
G
A
GPAGY
S
AA
F
R
C
AD
L
GL
ET
VI
V
------
ERY
N
TLGG
V
CLNVGCIPSKALLH
V
A
KV
I
E
E
AKAL
A
E
-
HG
IVFGE
P
KT
D
I
D
K
I
R
TW
K
E
K
VINQL
-
T
G
G
LA
G
MA
KG
R
K
-
VKV
V
N
GL
GK
F
T
G
A
N
----
TL
E
VE
-
G
EN
G
KT
VI
N
FDN
A
I
IA
A
GSRP
I
--
QLP
F
I
PHE
DPRIWDST
D
AL
E
L
KE
VPERLLV
M
G
G
G
I
IGLE
M
G
T
V
Y
HA
LGS
QI
D
V
VEM
F
D
QV
I
PA
A
D
KD
I
V
-K
V
FTK
R
IS
KK
FN
L
M
L
E
T
K
V
T
AVE
AK
E
---
DG
I
Y
V
T
-
ME
GKK
AP
A
E
PQ
R
Y
--
D
A
V
LVAIGRVPN
G
KN
LD
A
GKA
GVE
V
DDRG
F
I
R
VD
KQL
RTN
V
PHI
F
AIGD
I
VGQPMLAHK
G
VH
EG
H
VAAE
V
I
--
AG
K
K
H
YF
DP
---
KV
IPS
I
A
YT
E
PEVAWVG
L
TE
KE
AK
E
K
GI
S
YE
T
A
T
FP
W
A
AS
GRA
I
A
S
D
CAD
G
MT
KLIFDKES
H
RVIGGAIVG
TN
G
GEL
L
G
EI
G
LAIE
M
---
G
C
D
A
EDIA
L
TIHAHPTL
H
E
SVG
LAAEVFEGSITDLPNPKAKKK
fig|444453.5.peg.3393
Escherichia coli O157:H7 str. EC4076 (13-495/495)
AGDKYIEVMMSTEIKTQV
V
V
L
G
A
GPAGY
S
AA
F
R
C
AD
L
GL
ET
VI
V
------
ERY
N
TLGG
V
CLNVGCIPSKALLH
V
A
KV
I
E
E
AKAL
A
E
-
HG
IVFGE
P
KT
D
I
D
K
I
R
TW
K
E
K
VINQL
-
T
G
G
LA
G
MA
KG
R
K
-
VKV
V
N
GL
GK
F
T
G
A
N
----
TL
E
VE
-
G
EN
G
KT
VI
N
FDN
A
I
IA
A
GSRP
I
--
QLP
F
I
PHE
DPRIWDST
D
AL
E
L
KE
VPERLLV
M
G
G
G
I
IGLE
M
G
T
V
Y
HA
LGS
QI
D
V
VEM
F
D
QV
I
PA
A
D
KD
I
V
-K
V
FTK
R
IS
KK
FN
L
M
L
E
T
K
V
T
AVE
AK
E
---
DG
I
Y
V
T
-
ME
GKK
AP
A
E
PQ
R
Y
--
D
A
V
LVAIGRVPN
G
KN
LD
A
GKA
GVE
V
DDRG
F
I
R
VD
KQL
RTN
V
PHI
F
AIGD
I
VGQPMLAHK
G
VH
EG
H
VAAE
V
I
--
AG
K
K
H
YF
DP
---
KV
IPS
I
A
YT
E
PEVAWVG
L
TE
KE
AK
E
K
GI
S
YE
T
A
T
FP
W
A
AS
GRA
I
A
S
D
CAD
G
MT
KLIFDKES
H
RVIGGAIVG
TN
G
GEL
L
G
EI
G
LAIE
M
---
G
C
D
A
EDIA
L
TIHAHPTL
H
E
SVG
LAAEVFEGSITDLPNPKAKKK
fig|444452.5.peg.5406
Escherichia coli O157:H7 str. EC4113 (13-495/495)
AGDKYIEVMMSTEIKTQV
V
V
L
G
A
GPAGY
S
AA
F
R
C
AD
L
GL
ET
VI
V
------
ERY
N
TLGG
V
CLNVGCIPSKALLH
V
A
KV
I
E
E
AKAL
A
E
-
HG
IVFGE
P
KT
D
I
D
K
I
R
TW
K
E
K
VINQL
-
T
G
G
LA
G
MA
KG
R
K
-
VKV
V
N
GL
GK
F
T
G
A
N
----
TL
E
VE
-
G
EN
G
KT
VI
N
FDN
A
I
IA
A
GSRP
I
--
QLP
F
I
PHE
DPRIWDST
D
AL
E
L
KE
VPERLLV
M
G
G
G
I
IGLE
M
G
T
V
Y
HA
LGS
QI
D
V
VEM
F
D
QV
I
PA
A
D
KD
I
V
-K
V
FTK
R
IS
KK
FN
L
M
L
E
T
K
V
T
AVE
AK
E
---
DG
I
Y
V
T
-
ME
GKK
AP
A
E
PQ
R
Y
--
D
A
V
LVAIGRVPN
G
KN
LD
A
GKA
GVE
V
DDRG
F
I
R
VD
KQL
RTN
V
PHI
F
AIGD
I
VGQPMLAHK
G
VH
EG
H
VAAE
V
I
--
AG
K
K
H
YF
DP
---
KV
IPS
I
A
YT
E
PEVAWVG
L
TE
KE
AK
E
K
GI
S
YE
T
A
T
FP
W
A
AS
GRA
I
A
S
D
CAD
G
MT
KLIFDKES
H
RVIGGAIVG
TN
G
GEL
L
G
EI
G
LAIE
M
---
G
C
D
A
EDIA
L
TIHAHPTL
H
E
SVG
LAAEVFEGSITDLPNPKAKKK
fig|444450.8.peg.260
Escherichia coli O157:H7 str. EC4115 (13-495/495)
AGDKYIEVMMSTEIKTQV
V
V
L
G
A
GPAGY
S
AA
F
R
C
AD
L
GL
ET
VI
V
------
ERY
N
TLGG
V
CLNVGCIPSKALLH
V
A
KV
I
E
E
AKAL
A
E
-
HG
IVFGE
P
KT
D
I
D
K
I
R
TW
K
E
K
VINQL
-
T
G
G
LA
G
MA
KG
R
K
-
VKV
V
N
GL
GK
F
T
G
A
N
----
TL
E
VE
-
G
EN
G
KT
VI
N
FDN
A
I
IA
A
GSRP
I
--
QLP
F
I
PHE
DPRIWDST
D
AL
E
L
KE
VPERLLV
M
G
G
G
I
IGLE
M
G
T
V
Y
HA
LGS
QI
D
V
VEM
F
D
QV
I
PA
A
D
KD
I
V
-K
V
FTK
R
IS
KK
FN
L
M
L
E
T
K
V
T
AVE
AK
E
---
DG
I
Y
V
T
-
ME
GKK
AP
A
E
PQ
R
Y
--
D
A
V
LVAIGRVPN
G
KN
LD
A
GKA
GVE
V
DDRG
F
I
R
VD
KQL
RTN
V
PHI
F
AIGD
I
VGQPMLAHK
G
VH
EG
H
VAAE
V
I
--
AG
K
K
H
YF
DP
---
KV
IPS
I
A
YT
E
PEVAWVG
L
TE
KE
AK
E
K
GI
S
YE
T
A
T
FP
W
A
AS
GRA
I
A
S
D
CAD
G
MT
KLIFDKES
H
RVIGGAIVG
TN
G
GEL
L
G
EI
G
LAIE
M
---
G
C
D
A
EDIA
L
TIHAHPTL
H
E
SVG
LAAEVFEGSITDLPNPKAKKK
fig|444451.5.peg.4306
Escherichia coli O157:H7 str. EC4196 (13-495/495)
AGDKYIEVMMSTEIKTQV
V
V
L
G
A
GPAGY
S
AA
F
R
C
AD
L
GL
ET
VI
V
------
ERY
N
TLGG
V
CLNVGCIPSKALLH
V
A
KV
I
E
E
AKAL
A
E
-
HG
IVFGE
P
KT
D
I
D
K
I
R
TW
K
E
K
VINQL
-
T
G
G
LA
G
MA
KG
R
K
-
VKV
V
N
GL
GK
F
T
G
A
N
----
TL
E
VE
-
G
EN
G
KT
VI
N
FDN
A
I
IA
A
GSRP
I
--
QLP
F
I
PHE
DPRIWDST
D
AL
E
L
KE
VPERLLV
M
G
G
G
I
IGLE
M
G
T
V
Y
HA
LGS
QI
D
V
VEM
F
D
QV
I
PA
A
D
KD
I
V
-K
V
FTK
R
IS
KK
FN
L
M
L
E
T
K
V
T
AVE
AK
E
---
DG
I
Y
V
T
-
ME
GKK
AP
A
E
PQ
R
Y
--
D
A
V
LVAIGRVPN
G
KN
LD
A
GKA
GVE
V
DDRG
F
I
R
VD
KQL
RTN
V
PHI
F
AIGD
I
VGQPMLAHK
G
VH
EG
H
VAAE
V
I
--
AG
K
K
H
YF
DP
---
KV
IPS
I
A
YT
E
PEVAWVG
L
TE
KE
AK
E
K
GI
S
YE
T
A
T
FP
W
A
AS
GRA
I
A
S
D
CAD
G
MT
KLIFDKES
H
RVIGGAIVG
TN
G
GEL
L
G
EI
G
LAIE
M
---
G
C
D
A
EDIA
L
TIHAHPTL
H
E
SVG
LAAEVFEGSITDLPNPKAKKK
fig|444447.5.peg.2962
Escherichia coli O157:H7 str. EC4206 (13-495/495)
AGDKYIEVMMSTEIKTQV
V
V
L
G
A
GPAGY
S
AA
F
R
C
AD
L
GL
ET
VI
V
------
ERY
N
TLGG
V
CLNVGCIPSKALLH
V
A
KV
I
E
E
AKAL
A
E
-
HG
IVFGE
P
KT
D
I
D
K
I
R
TW
K
E
K
VINQL
-
T
G
G
LA
G
MA
KG
R
K
-
VKV
V
N
GL
GK
F
T
G
A
N
----
TL
E
VE
-
G
EN
G
KT
VI
N
FDN
A
I
IA
A
GSRP
I
--
QLP
F
I
PHE
DPRIWDST
D
AL
E
L
KE
VPERLLV
M
G
G
G
I
IGLE
M
G
T
V
Y
HA
LGS
QI
D
V
VEM
F
D
QV
I
PA
A
D
KD
I
V
-K
V
FTK
R
IS
KK
FN
L
M
L
E
T
K
V
T
AVE
AK
E
---
DG
I
Y
V
T
-
ME
GKK
AP
A
E
PQ
R
Y
--
D
A
V
LVAIGRVPN
G
KN
LD
A
GKA
GVE
V
DDRG
F
I
R
VD
KQL
RTN
V
PHI
F
AIGD
I
VGQPMLAHK
G
VH
EG
H
VAAE
V
I
--
AG
K
K
H
YF
DP
---
KV
IPS
I
A
YT
E
PEVAWVG
L
TE
KE
AK
E
K
GI
S
YE
T
A
T
FP
W
A
AS
GRA
I
A
S
D
CAD
G
MT
KLIFDKES
H
RVIGGAIVG
TN
G
GEL
L
G
EI
G
LAIE
M
---
G
C
D
A
EDIA
L
TIHAHPTL
H
E
SVG
LAAEVFEGSITDLPNPKAKKK
fig|478004.5.peg.2492
Escherichia coli O157:H7 str. EC4401 (13-495/495)
AGDKYIEVMMSTEIKTQV
V
V
L
G
A
GPAGY
S
AA
F
R
C
AD
L
GL
ET
VI
V
------
ERY
N
TLGG
V
CLNVGCIPSKALLH
V
A
KV
I
E
E
AKAL
A
E
-
HG
IVFGE
P
KT
D
I
D
K
I
R
TW
K
E
K
VINQL
-
T
G
G
LA
G
MA
KG
R
K
-
VKV
V
N
GL
GK
F
T
G
A
N
----
TL
E
VE
-
G
EN
G
KT
VI
N
FDN
A
I
IA
A
GSRP
I
--
QLP
F
I
PHE
DPRIWDST
D
AL
E
L
KE
VPERLLV
M
G
G
G
I
IGLE
M
G
T
V
Y
HA
LGS
QI
D
V
VEM
F
D
QV
I
PA
A
D
KD
I
V
-K
V
FTK
R
IS
KK
FN
L
M
L
E
T
K
V
T
AVE
AK
E
---
DG
I
Y
V
T
-
ME
GKK
AP
A
E
PQ
R
Y
--
D
A
V
LVAIGRVPN
G
KN
LD
A
GKA
GVE
V
DDRG
F
I
R
VD
KQL
RTN
V
PHI
F
AIGD
I
VGQPMLAHK
G
VH
EG
H
VAAE
V
I
--
AG
K
K
H
YF
DP
---
KV
IPS
I
A
YT
E
PEVAWVG
L
TE
KE
AK
E
K
GI
S
YE
T
A
T
FP
W
A
AS
GRA
I
A
S
D
CAD
G
MT
KLIFDKES
H
RVIGGAIVG
TN
G
GEL
L
G
EI
G
LAIE
M
---
G
C
D
A
EDIA
L
TIHAHPTL
H
E
SVG
LAAEVFEGSITDLPNPKAKKK
fig|478006.5.peg.5128
Escherichia coli O157:H7 str. EC4501 (13-495/495)
AGDKYIEVMMSTEIKTQV
V
V
L
G
A
GPAGY
S
AA
F
R
C
AD
L
GL
ET
VI
V
------
ERY
N
TLGG
V
CLNVGCIPSKALLH
V
A
KV
I
E
E
AKAL
A
E
-
HG
IVFGE
P
KT
D
I
D
K
I
R
TW
K
E
K
VINQL
-
T
G
G
LA
G
MA
KG
R
K
-
VKV
V
N
GL
GK
F
T
G
A
N
----
TL
E
VE
-
G
EN
G
KT
VI
N
FDN
A
I
IA
A
GSRP
I
--
QLP
F
I
PHE
DPRIWDST
D
AL
E
L
KE
VPERLLV
M
G
G
G
I
IGLE
M
G
T
V
Y
HA
LGS
QI
D
V
VEM
F
D
QV
I
PA
A
D
KD
I
V
-K
V
FTK
R
IS
KK
FN
L
M
L
E
T
K
V
T
AVE
AK
E
---
DG
I
Y
V
T
-
ME
GKK
AP
A
E
PQ
R
Y
--
D
A
V
LVAIGRVPN
G
KN
LD
A
GKA
GVE
V
DDRG
F
I
R
VD
KQL
RTN
V
PHI
F
AIGD
I
VGQPMLAHK
G
VH
EG
H
VAAE
V
I
--
AG
K
K
H
YF
DP
---
KV
IPS
I
A
YT
E
PEVAWVG
L
TE
KE
AK
E
K
GI
S
YE
T
A
T
FP
W
A
AS
GRA
I
A
S
D
CAD
G
MT
KLIFDKES
H
RVIGGAIVG
TN
G
GEL
L
G
EI
G
LAIE
M
---
G
C
D
A
EDIA
L
TIHAHPTL
H
E
SVG
LAAEVFEGSITDLPNPKAKKK
fig|478007.5.peg.4060
Escherichia coli O157:H7 str. EC508 (13-495/495)
AGDKYIEVMMSTEIKTQV
V
V
L
G
A
GPAGY
S
AA
F
R
C
AD
L
GL
ET
VI
V
------
ERY
N
TLGG
V
CLNVGCIPSKALLH
V
A
KV
I
E
E
AKAL
A
E
-
HG
IVFGE
P
KT
D
I
D
K
I
R
TW
K
E
K
VINQL
-
T
G
G
LA
G
MA
KG
R
K
-
VKV
V
N
GL
GK
F
T
G
A
N
----
TL
E
VE
-
G
EN
G
KT
VI
N
FDN
A
I
IA
A
GSRP
I
--
QLP
F
I
PHE
DPRIWDST
D
AL
E
L
KE
VPERLLV
M
G
G
G
I
IGLE
M
G
T
V
Y
HA
LGS
QI
D
V
VEM
F
D
QV
I
PA
A
D
KD
I
V
-K
V
FTK
R
IS
KK
FN
L
M
L
E
T
K
V
T
AVE
AK
E
---
DG
I
Y
V
T
-
ME
GKK
AP
A
E
PQ
R
Y
--
D
A
V
LVAIGRVPN
G
KN
LD
A
GKA
GVE
V
DDRG
F
I
R
VD
KQL
RTN
V
PHI
F
AIGD
I
VGQPMLAHK
G
VH
EG
H
VAAE
V
I
--
AG
K
K
H
YF
DP
---
KV
IPS
I
A
YT
E
PEVAWVG
L
TE
KE
AK
E
K
GI
S
YE
T
A
T
FP
W
A
AS
GRA
I
A
S
D
CAD
G
MT
KLIFDKES
H
RVIGGAIVG
TN
G
GEL
L
G
EI
G
LAIE
M
---
G
C
D
A
EDIA
L
TIHAHPTL
H
E
SVG
LAAEVFEGSITDLPNPKAKKK
fig|478008.5.peg.4705
Escherichia coli O157:H7 str. EC869 (13-495/495)
AGDKYIEVMMSTEIKTQV
V
V
L
G
A
GPAGY
S
AA
F
R
C
AD
L
GL
ET
VI
V
------
ERY
N
TLGG
V
CLNVGCIPSKALLH
V
A
KV
I
E
E
AKAL
A
E
-
HG
IVFGE
P
KT
D
I
D
K
I
R
TW
K
E
K
VINQL
-
T
G
G
LA
G
MA
KG
R
K
-
VKV
V
N
GL
GK
F
T
G
A
N
----
TL
E
VE
-
G
EN
G
KT
VI
N
FDN
A
I
IA
A
GSRP
I
--
QLP
F
I
PHE
DPRIWDST
D
AL
E
L
KE
VPERLLV
M
G
G
G
I
IGLE
M
G
T
V
Y
HA
LGS
QI
D
V
VEM
F
D
QV
I
PA
A
D
KD
I
V
-K
V
FTK
R
IS
KK
FN
L
M
L
E
T
K
V
T
AVE
AK
E
---
DG
I
Y
V
T
-
ME
GKK
AP
A
E
PQ
R
Y
--
D
A
V
LVAIGRVPN
G
KN
LD
A
GKA
GVE
V
DDRG
F
I
R
VD
KQL
RTN
V
PHI
F
AIGD
I
VGQPMLAHK
G
VH
EG
H
VAAE
V
I
--
AG
K
K
H
YF
DP
---
KV
IPS
I
A
YT
E
PEVAWVG
L
TE
KE
AK
E
K
GI
S
YE
T
A
T
FP
W
A
AS
GRA
I
A
S
D
CAD
G
MT
KLIFDKES
H
RVIGGAIVG
TN
G
GEL
L
G
EI
G
LAIE
M
---
G
C
D
A
EDIA
L
TIHAHPTL
H
E
SVG
LAAEVFEGSITDLPNPKAKKK
fig|637388.3.peg.3957
Escherichia coli O157:H7 str. FRIK2000 (13-495/495)
AGDKYIEVMMSTEIKTQV
V
V
L
G
A
GPAGY
S
AA
F
R
C
AD
L
GL
ET
VI
V
------
ERY
N
TLGG
V
CLNVGCIPSKALLH
V
A
KV
I
E
E
AKAL
A
E
-
HG
IVFGE
P
KT
D
I
D
K
I
R
TW
K
E
K
VINQL
-
T
G
G
LA
G
MA
KG
R
K
-
VKV
V
N
GL
GK
F
T
G
A
N
----
TL
E
VE
-
G
EN
G
KT
VI
N
FDN
A
I
IA
A
GSRP
I
--
QLP
F
I
PHE
DPRIWDST
D
AL
E
L
KE
VPERLLV
M
G
G
G
I
IGLE
M
G
T
V
Y
HA
LGS
QI
D
V
VEM
F
D
QV
I
PA
A
D
KD
I
V
-K
V
FTK
R
IS
KK
FN
L
M
L
E
T
K
V
T
AVE
AK
E
---
DG
I
Y
V
T
-
ME
GKK
AP
A
E
PQ
R
Y
--
D
A
V
LVAIGRVPN
G
KN
LD
A
GKA
GVE
V
DDRG
F
I
R
VD
KQL
RTN
V
PHI
F
AIGD
I
VGQPMLAHK
G
VH
EG
H
VAAE
V
I
--
AG
K
K
H
YF
DP
---
KV
IPS
I
A
YT
E
PEVAWVG
L
TE
KE
AK
E
K
GI
S
YE
T
A
T
FP
W
A
AS
GRA
I
A
S
D
CAD
G
MT
KLIFDKES
H
RVIGGAIVG
TN
G
GEL
L
G
EI
G
LAIE
M
---
G
C
D
A
EDIA
L
TIHAHPTL
H
E
SVG
LAAEVFEGSITDLPNPKAKKK
fig|570506.3.peg.1121
Escherichia coli O157:H7 str. FRIK966 (13-495/495)
AGDKYIEVMMSTEIKTQV
V
V
L
G
A
GPAGY
S
AA
F
R
C
AD
L
GL
ET
VI
V
------
ERY
N
TLGG
V
CLNVGCIPSKALLH
V
A
KV
I
E
E
AKAL
A
E
-
HG
IVFGE
P
KT
D
I
D
K
I
R
TW
K
E
K
VINQL
-
T
G
G
LA
G
MA
KG
R
K
-
VKV
V
N
GL
GK
F
T
G
A
N
----
TL
E
VE
-
G
EN
G
KT
VI
N
FDN
A
I
IA
A
GSRP
I
--
QLP
F
I
PHE
DPRIWDST
D
AL
E
L
KE
VPERLLV
M
G
G
G
I
IGLE
M
G
T
V
Y
HA
LGS
QI
D
V
VEM
F
D
QV
I
PA
A
D
KD
I
V
-K
V
FTK
R
IS
KK
FN
L
M
L
E
T
K
V
T
AVE
AK
E
---
DG
I
Y
V
T
-
ME
GKK
AP
A
E
PQ
R
Y
--
D
A
V
LVAIGRVPN
G
KN
LD
A
GKA
GVE
V
DDRG
F
I
R
VD
KQL
RTN
V
PHI
F
AIGD
I
VGQPMLAHK
G
VH
EG
H
VAAE
V
I
--
AG
K
K
H
YF
DP
---
KV
IPS
I
A
YT
E
PEVAWVG
L
TE
KE
AK
E
K
GI
S
YE
T
A
T
FP
W
A
AS
GRA
I
A
S
D
CAD
G
MT
KLIFDKES
H
RVIGGAIVG
TN
G
GEL
L
G
EI
G
LAIE
M
---
G
C
D
A
EDIA
L
TIHAHPTL
H
E
SVG
LAAEVFEGSITDLPNPKAKKK
fig|386585.9.peg.218
Escherichia coli O157:H7 str. Sakai (13-495/495)
AGDKYIEVMMSTEIKTQV
V
V
L
G
A
GPAGY
S
AA
F
R
C
AD
L
GL
ET
VI
V
------
ERY
N
TLGG
V
CLNVGCIPSKALLH
V
A
KV
I
E
E
AKAL
A
E
-
HG
IVFGE
P
KT
D
I
D
K
I
R
TW
K
E
K
VINQL
-
T
G
G
LA
G
MA
KG
R
K
-
VKV
V
N
GL
GK
F
T
G
A
N
----
TL
E
VE
-
G
EN
G
KT
VI
N
FDN
A
I
IA
A
GSRP
I
--
QLP
F
I
PHE
DPRIWDST
D
AL
E
L
KE
VPERLLV
M
G
G
G
I
IGLE
M
G
T
V
Y
HA
LGS
QI
D
V
VEM
F
D
QV
I
PA
A
D
KD
I
V
-K
V
FTK
R
IS
KK
FN
L
M
L
E
T
K
V
T
AVE
AK
E
---
DG
I
Y
V
T
-
ME
GKK
AP
A
E
PQ
R
Y
--
D
A
V
LVAIGRVPN
G
KN
LD
A
GKA
GVE
V
DDRG
F
I
R
VD
KQL
RTN
V
PHI
F
AIGD
I
VGQPMLAHK
G
VH
EG
H
VAAE
V
I
--
AG
K
K
H
YF
DP
---
KV
IPS
I
A
YT
E
PEVAWVG
L
TE
KE
AK
E
K
GI
S
YE
T
A
T
FP
W
A
AS
GRA
I
A
S
D
CAD
G
MT
KLIFDKES
H
RVIGGAIVG
TN
G
GEL
L
G
EI
G
LAIE
M
---
G
C
D
A
EDIA
L
TIHAHPTL
H
E
SVG
LAAEVFEGSITDLPNPKAKKK
fig|544404.4.peg.122
Escherichia coli O157:H7 str. TW14359 (13-495/495)
AGDKYIEVMMSTEIKTQV
V
V
L
G
A
GPAGY
S
AA
F
R
C
AD
L
GL
ET
VI
V
------
ERY
N
TLGG
V
CLNVGCIPSKALLH
V
A
KV
I
E
E
AKAL
A
E
-
HG
IVFGE
P
KT
D
I
D
K
I
R
TW
K
E
K
VINQL
-
T
G
G
LA
G
MA
KG
R
K
-
VKV
V
N
GL
GK
F
T
G
A
N
----
TL
E
VE
-
G
EN
G
KT
VI
N
FDN
A
I
IA
A
GSRP
I
--
QLP
F
I
PHE
DPRIWDST
D
AL
E
L
KE
VPERLLV
M
G
G
G
I
IGLE
M
G
T
V
Y
HA
LGS
QI
D
V
VEM
F
D
QV
I
PA
A
D
KD
I
V
-K
V
FTK
R
IS
KK
FN
L
M
L
E
T
K
V
T
AVE
AK
E
---
DG
I
Y
V
T
-
ME
GKK
AP
A
E
PQ
R
Y
--
D
A
V
LVAIGRVPN
G
KN
LD
A
GKA
GVE
V
DDRG
F
I
R
VD
KQL
RTN
V
PHI
F
AIGD
I
VGQPMLAHK
G
VH
EG
H
VAAE
V
I
--
AG
K
K
H
YF
DP
---
KV
IPS
I
A
YT
E
PEVAWVG
L
TE
KE
AK
E
K
GI
S
YE
T
A
T
FP
W
A
AS
GRA
I
A
S
D
CAD
G
MT
KLIFDKES
H
RVIGGAIVG
TN
G
GEL
L
G
EI
G
LAIE
M
---
G
C
D
A
EDIA
L
TIHAHPTL
H
E
SVG
LAAEVFEGSITDLPNPKAKKK
fig|502346.5.peg.1145
Escherichia coli O157:H7 str. TW14588 (13-495/495)
AGDKYIEVMMSTEIKTQV
V
V
L
G
A
GPAGY
S
AA
F
R
C
AD
L
GL
ET
VI
V
------
ERY
N
TLGG
V
CLNVGCIPSKALLH
V
A
KV
I
E
E
AKAL
A
E
-
HG
IVFGE
P
KT
D
I
D
K
I
R
TW
K
E
K
VINQL
-
T
G
G
LA
G
MA
KG
R
K
-
VKV
V
N
GL
GK
F
T
G
A
N
----
TL
E
VE
-
G
EN
G
KT
VI
N
FDN
A
I
IA
A
GSRP
I
--
QLP
F
I
PHE
DPRIWDST
D
AL
E
L
KE
VPERLLV
M
G
G
G
I
IGLE
M
G
T
V
Y
HA
LGS
QI
D
V
VEM
F
D
QV
I
PA
A
D
KD
I
V
-K
V
FTK
R
IS
KK
FN
L
M
L
E
T
K
V
T
AVE
AK
E
---
DG
I
Y
V
T
-
ME
GKK
AP
A
E
PQ
R
Y
--
D
A
V
LVAIGRVPN
G
KN
LD
A
GKA
GVE
V
DDRG
F
I
R
VD
KQL
RTN
V
PHI
F
AIGD
I
VGQPMLAHK
G
VH
EG
H
VAAE
V
I
--
AG
K
K
H
YF
DP
---
KV
IPS
I
A
YT
E
PEVAWVG
L
TE
KE
AK
E
K
GI
S
YE
T
A
T
FP
W
A
AS
GRA
I
A
S
D
CAD
G
MT
KLIFDKES
H
RVIGGAIVG
TN
G
GEL
L
G
EI
G
LAIE
M
---
G
C
D
A
EDIA
L
TIHAHPTL
H
E
SVG
LAAEVFEGSITDLPNPKAKKK
fig|701177.3.peg.120
Escherichia coli O55:H7 str. CB9615 (13-495/495)
AGDKYIEVMMSTEIKTQV
V
V
L
G
A
GPAGY
S
AA
F
R
C
AD
L
GL
ET
VI
V
------
ERY
N
TLGG
V
CLNVGCIPSKALLH
V
A
KV
I
E
E
AKAL
A
E
-
HG
IVFGE
P
KT
D
I
D
K
I
R
TW
K
E
K
VINQL
-
T
G
G
LA
G
MA
KG
R
K
-
VKV
V
N
GL
GK
F
T
G
A
N
----
TL
E
VE
-
G
EN
G
KT
VI
N
FDN
A
I
IA
A
GSRP
I
--
QLP
F
I
PHE
DPRIWDST
D
AL
E
L
KE
VPERLLV
M
G
G
G
I
IGLE
M
G
T
V
Y
HA
LGS
QI
D
V
VEM
F
D
QV
I
PA
A
D
KD
I
V
-K
V
FTK
R
IS
KK
FN
L
M
L
E
T
K
V
T
AVE
AK
E
---
DG
I
Y
V
T
-
ME
GKK
AP
A
E
PQ
R
Y
--
D
A
V
LVAIGRVPN
G
KN
LD
A
GKA
GVE
V
DDRG
F
I
R
VD
KQL
RTN
V
PHI
F
AIGD
I
VGQPMLAHK
G
VH
EG
H
VAAE
V
I
--
AG
K
K
H
YF
DP
---
KV
IPS
I
A
YT
E
PEVAWVG
L
TE
KE
AK
E
K
GI
S
YE
T
A
T
FP
W
A
AS
GRA
I
A
S
D
CAD
G
MT
KLIFDKES
H
RVIGGAIVG
TN
G
GEL
L
G
EI
G
LAIE
M
---
G
C
D
A
EDIA
L
TIHAHPTL
H
E
SVG
LAAEVFEGSITDLPNPKAKKK
fig|685038.3.peg.120
Escherichia coli O83:H1 str. NRG 857C (13-495/495)
AGDKYIEVMMSTEIKTQV
V
V
L
G
A
GPAGY
S
AA
F
R
C
AD
L
GL
ET
VI
V
------
ERY
N
TLGG
V
CLNVGCIPSKALLH
V
A
KV
I
E
E
AKAL
A
E
-
HG
IVFGE
P
KT
D
I
D
K
I
R
TW
K
E
K
VINQL
-
T
G
G
LA
G
MA
KG
R
K
-
VKV
V
N
GL
GK
F
T
G
A
N
----
TL
E
VE
-
G
EN
G
KT
VI
N
FDN
A
I
IA
A
GSRP
I
--
QLP
F
I
PHE
DPRIWDST
D
AL
E
L
KE
VPERLLV
M
G
G
G
I
IGLE
M
G
T
V
Y
HA
LGS
QI
D
V
VEM
F
D
QV
I
PA
A
D
KD
I
V
-K
V
FTK
R
IS
KK
FN
L
M
L
E
T
K
V
T
AVE
AK
E
---
DG
I
Y
V
T
-
ME
GKK
AP
A
E
PQ
R
Y
--
D
A
V
LVAIGRVPN
G
KN
LD
A
GKA
GVE
V
DDRG
F
I
R
VD
KQL
RTN
V
PHI
F
AIGD
I
VGQPMLAHK
G
VH
EG
H
VAAE
V
I
--
AG
K
K
H
YF
DP
---
KV
IPS
I
A
YT
E
PEVAWVG
L
TE
KE
AK
E
K
GI
S
YE
T
A
T
FP
W
A
AS
GRA
I
A
S
D
CAD
G
MT
KLIFDKES
H
RVIGGAIVG
TN
G
GEL
L
G
EI
G
LAIE
M
---
G
C
D
A
EDIA
L
TIHAHPTL
H
E
SVG
LAAEVFEGSITDLPNPKAKKK
fig|431946.3.peg.130
Escherichia coli SE15 (13-495/495)
AGDKYIEVMMSTEIKTQV
V
V
L
G
A
GPAGY
S
AA
F
R
C
AD
L
GL
ET
VI
V
------
ERY
N
TLGG
V
CLNVGCIPSKALLH
V
A
KV
I
E
E
AKAL
A
E
-
HG
IVFGE
P
KT
D
I
D
K
I
R
TW
K
E
K
VINQL
-
T
G
G
LA
G
MA
KG
R
K
-
VKV
V
N
GL
GK
F
T
G
A
N
----
TL
E
VE
-
G
EN
G
KT
VI
N
FDN
A
I
IA
A
GSRP
I
--
QLP
F
I
PHE
DPRIWDST
D
AL
E
L
KE
VPERLLV
M
G
G
G
I
IGLE
M
G
T
V
Y
HA
LGS
QI
D
V
VEM
F
D
QV
I
PA
A
D
KD
I
V
-K
V
FTK
R
IS
KK
FN
L
M
L
E
T
K
V
T
AVE
AK
E
---
DG
I
Y
V
T
-
ME
GKK
AP
A
E
PQ
R
Y
--
D
A
V
LVAIGRVPN
G
KN
LD
A
GKA
GVE
V
DDRG
F
I
R
VD
KQL
RTN
V
PHI
F
AIGD
I
VGQPMLAHK
G
VH
EG
H
VAAE
V
I
--
AG
K
K
H
YF
DP
---
KV
IPS
I
A
YT
E
PEVAWVG
L
TE
KE
AK
E
K
GI
S
YE
T
A
T
FP
W
A
AS
GRA
I
A
S
D
CAD
G
MT
KLIFDKES
H
RVIGGAIVG
TN
G
GEL
L
G
EI
G
LAIE
M
---
G
C
D
A
EDIA
L
TIHAHPTL
H
E
SVG
LAAEVFEGSITDLPNPKAKKK
fig|656440.3.peg.5185
Escherichia coli TA206 (13-495/495)
AGDKYIEVMMSTEIKTQV
V
V
L
G
A
GPAGY
S
AA
F
R
C
AD
L
GL
ET
VI
V
------
ERY
N
TLGG
V
CLNVGCIPSKALLH
V
A
KV
I
E
E
AKAL
A
E
-
HG
IVFGE
P
KT
D
I
D
K
I
R
TW
K
E
K
VINQL
-
T
G
G
LA
G
MA
KG
R
K
-
VKV
V
N
GL
GK
F
T
G
A
N
----
TL
E
VE
-
G
EN
G
KT
VI
N
FDN
A
I
IA
A
GSRP
I
--
QLP
F
I
PHE
DPRIWDST
D
AL
E
L
KE
VPERLLV
M
G
G
G
I
IGLE
M
G
T
V
Y
HA
LGS
QI
D
V
VEM
F
D
QV
I
PA
A
D
KD
I
V
-K
V
FTK
R
IS
KK
FN
L
M
L
E
T
K
V
T
AVE
AK
E
---
DG
I
Y
V
T
-
ME
GKK
AP
A
E
PQ
R
Y
--
D
A
V
LVAIGRVPN
G
KN
LD
A
GKA
GVE
V
DDRG
F
I
R
VD
KQL
RTN
V
PHI
F
AIGD
I
VGQPMLAHK
G
VH
EG
H
VAAE
V
I
--
AG
K
K
H
YF
DP
---
KV
IPS
I
A
YT
E
PEVAWVG
L
TE
KE
AK
E
K
GI
S
YE
T
A
T
FP
W
A
AS
GRA
I
A
S
D
CAD
G
MT
KLIFDKES
H
RVIGGAIVG
TN
G
GEL
L
G
EI
G
LAIE
M
---
G
C
D
A
EDIA
L
TIHAHPTL
H
E
SVG
LAAEVFEGSITDLPNPKAKKK
fig|869729.3.peg.5031
Escherichia coli UM146 (13-495/495)
AGDKYIEVMMSTEIKTQV
V
V
L
G
A
GPAGY
S
AA
F
R
C
AD
L
GL
ET
VI
V
------
ERY
N
TLGG
V
CLNVGCIPSKALLH
V
A
KV
I
E
E
AKAL
A
E
-
HG
IVFGE
P
KT
D
I
D
K
I
R
TW
K
E
K
VINQL
-
T
G
G
LA
G
MA
KG
R
K
-
VKV
V
N
GL
GK
F
T
G
A
N
----
TL
E
VE
-
G
EN
G
KT
VI
N
FDN
A
I
IA
A
GSRP
I
--
QLP
F
I
PHE
DPRIWDST
D
AL
E
L
KE
VPERLLV
M
G
G
G
I
IGLE
M
G
T
V
Y
HA
LGS
QI
D
V
VEM
F
D
QV
I
PA
A
D
KD
I
V
-K
V
FTK
R
IS
KK
FN
L
M
L
E
T
K
V
T
AVE
AK
E
---
DG
I
Y
V
T
-
ME
GKK
AP
A
E
PQ
R
Y
--
D
A
V
LVAIGRVPN
G
KN
LD
A
GKA
GVE
V
DDRG
F
I
R
VD
KQL
RTN
V
PHI
F
AIGD
I
VGQPMLAHK
G
VH
EG
H
VAAE
V
I
--
AG
K
K
H
YF
DP
---
KV
IPS
I
A
YT
E
PEVAWVG
L
TE
KE
AK
E
K
GI
S
YE
T
A
T
FP
W
A
AS
GRA
I
A
S
D
CAD
G
MT
KLIFDKES
H
RVIGGAIVG
TN
G
GEL
L
G
EI
G
LAIE
M
---
G
C
D
A
EDIA
L
TIHAHPTL
H
E
SVG
LAAEVFEGSITDLPNPKAKKK
fig|364106.7.peg.258
Escherichia coli UTI89 (13-495/495)
AGDKYIEVMMSTEIKTQV
V
V
L
G
A
GPAGY
S
AA
F
R
C
AD
L
GL
ET
VI
V
------
ERY
N
TLGG
V
CLNVGCIPSKALLH
V
A
KV
I
E
E
AKAL
A
E
-
HG
IVFGE
P
KT
D
I
D
K
I
R
TW
K
E
K
VINQL
-
T
G
G
LA
G
MA
KG
R
K
-
VKV
V
N
GL
GK
F
T
G
A
N
----
TL
E
VE
-
G
EN
G
KT
VI
N
FDN
A
I
IA
A
GSRP
I
--
QLP
F
I
PHE
DPRIWDST
D
AL
E
L
KE
VPERLLV
M
G
G
G
I
IGLE
M
G
T
V
Y
HA
LGS
QI
D
V
VEM
F
D
QV
I
PA
A
D
KD
I
V
-K
V
FTK
R
IS
KK
FN
L
M
L
E
T
K
V
T
AVE
AK
E
---
DG
I
Y
V
T
-
ME
GKK
AP
A
E
PQ
R
Y
--
D
A
V
LVAIGRVPN
G
KN
LD
A
GKA
GVE
V
DDRG
F
I
R
VD
KQL
RTN
V
PHI
F
AIGD
I
VGQPMLAHK
G
VH
EG
H
VAAE
V
I
--
AG
K
K
H
YF
DP
---
KV
IPS
I
A
YT
E
PEVAWVG
L
TE
KE
AK
E
K
GI
S
YE
T
A
T
FP
W
A
AS
GRA
I
A
S
D
CAD
G
MT
KLIFDKES
H
RVIGGAIVG
TN
G
GEL
L
G
EI
G
LAIE
M
---
G
C
D
A
EDIA
L
TIHAHPTL
H
E
SVG
LAAEVFEGSITDLPNPKAKKK
fig|364106.8.peg.257
Escherichia coli UTI89 (13-495/495)
AGDKYIEVMMSTEIKTQV
V
V
L
G
A
GPAGY
S
AA
F
R
C
AD
L
GL
ET
VI
V
------
ERY
N
TLGG
V
CLNVGCIPSKALLH
V
A
KV
I
E
E
AKAL
A
E
-
HG
IVFGE
P
KT
D
I
D
K
I
R
TW
K
E
K
VINQL
-
T
G
G
LA
G
MA
KG
R
K
-
VKV
V
N
GL
GK
F
T
G
A
N
----
TL
E
VE
-
G
EN
G
KT
VI
N
FDN
A
I
IA
A
GSRP
I
--
QLP
F
I
PHE
DPRIWDST
D
AL
E
L
KE
VPERLLV
M
G
G
G
I
IGLE
M
G
T
V
Y
HA
LGS
QI
D
V
VEM
F
D
QV
I
PA
A
D
KD
I
V
-K
V
FTK
R
IS
KK
FN
L
M
L
E
T
K
V
T
AVE
AK
E
---
DG
I
Y
V
T
-
ME
GKK
AP
A
E
PQ
R
Y
--
D
A
V
LVAIGRVPN
G
KN
LD
A
GKA
GVE
V
DDRG
F
I
R
VD
KQL
RTN
V
PHI
F
AIGD
I
VGQPMLAHK
G
VH
EG
H
VAAE
V
I
--
AG
K
K
H
YF
DP
---
KV
IPS
I
A
YT
E
PEVAWVG
L
TE
KE
AK
E
K
GI
S
YE
T
A
T
FP
W
A
AS
GRA
I
A
S
D
CAD
G
MT
KLIFDKES
H
RVIGGAIVG
TN
G
GEL
L
G
EI
G
LAIE
M
---
G
C
D
A
EDIA
L
TIHAHPTL
H
E
SVG
LAAEVFEGSITDLPNPKAKKK
fig|405955.9.peg.101
Escherichia coli APEC O1
MMSTEIKTQV
V
V
L
G
A
GPAGY
S
AA
F
R
C
AD
L
GL
ET
VI
V
------
ERY
N
TLGG
V
CLNVGCIPSKALLH
V
A
KV
I
E
E
AKAL
A
E
-
HG
IVFGE
P
KT
D
I
D
K
I
R
TW
K
E
K
VINQL
-
T
G
G
LA
G
MA
KG
R
K
-
VKV
V
N
GL
GK
F
T
G
A
N
----
TL
E
VE
-
G
EN
G
KT
VI
N
FDN
A
I
IA
A
GSRP
I
--
QLP
F
I
PHE
DPRIWDST
D
AL
E
L
KE
VPERLLV
M
G
G
G
I
IGLE
M
G
T
V
Y
HA
LGS
QI
D
V
VEM
F
D
QV
I
PA
A
D
KD
I
V
-K
V
FTK
R
IS
KK
FN
L
M
L
E
T
K
V
T
AVE
AK
E
---
DG
I
Y
V
T
-
ME
GKK
AP
A
E
PQ
R
Y
--
D
A
V
LVAIGRVPN
G
KN
LD
A
GKA
GVE
V
DDRG
F
I
R
VD
KQL
RTN
V
PHI
F
AIGD
I
VGQPMLAHK
G
VH
EG
H
VAAE
V
I
--
AG
K
K
H
YF
DP
---
KV
IPS
I
A
YT
E
PEVAWVG
L
TE
KE
AK
E
K
GI
S
YE
T
A
T
FP
W
A
AS
GRA
I
A
S
D
CAD
G
MT
KLIFDKES
H
RVIGGAIVG
TN
G
GEL
L
G
EI
G
LAIE
M
---
G
C
D
A
EDIA
L
TIHAHPTL
H
E
SVG
LAAEVFEGSITDLPNPKAKKK
fig|216592.3.peg.125
Escherichia coli 042
MSTEIKTQV
V
V
L
G
A
GPAGY
S
AA
F
R
C
AD
L
GL
ET
VI
V
------
ERY
N
TLGG
V
CLNVGCIPSKALLH
V
A
KV
I
E
E
AKAL
A
E
-
HG
IVFGE
P
KT
D
I
D
K
I
R
TW
K
E
K
VINQL
-
T
G
G
LA
G
MA
KG
R
K
-
VKV
V
N
GL
GK
F
T
G
A
N
----
TL
E
VE
-
G
EN
G
KT
VI
N
FDN
A
I
IA
A
GSRP
I
--
QLP
F
I
PHE
DPRIWDST
D
AL
E
L
KE
VPERLLV
M
G
G
G
I
IGLE
M
G
T
V
Y
HA
LGS
QI
D
V
VEM
F
D
QV
I
PA
A
D
KD
I
V
-K
V
FTK
R
IS
KK
FN
L
M
L
E
T
K
V
T
AVE
AK
E
---
DG
I
Y
V
T
-
ME
GKK
AP
A
E
PQ
R
Y
--
D
A
V
LVAIGRVPN
G
KN
LD
A
GKA
GVE
V
DDRG
F
I
R
VD
KQL
RTN
V
PHI
F
AIGD
I
VGQPMLAHK
G
VH
EG
H
VAAE
V
I
--
AG
K
K
H
YF
DP
---
KV
IPS
I
A
YT
E
PEVAWVG
L
TE
KE
AK
E
K
GI
S
YE
T
A
T
FP
W
A
AS
GRA
I
A
S
D
CAD
G
MT
KLIFDKES
H
RVIGGAIVG
TN
G
GEL
L
G
EI
G
LAIE
M
---
G
C
D
A
EDIA
L
TIHAHPTL
H
E
SVG
LAAEVFEGSITDLPNPKAKKK
fig|670897.3.peg.1935
Escherichia coli 2362-75
MSTEIKTQV
V
V
L
G
A
GPAGY
S
AA
F
R
C
AD
L
GL
ET
VI
V
------
ERY
N
TLGG
V
CLNVGCIPSKALLH
V
A
KV
I
E
E
AKAL
A
E
-
HG
IVFGE
P
KT
D
I
D
K
I
R
TW
K
E
K
VINQL
-
T
G
G
LA
G
MA
KG
R
K
-
VKV
V
N
GL
GK
F
T
G
A
N
----
TL
E
VE
-
G
EN
G
KT
VI
N
FDN
A
I
IA
A
GSRP
I
--
QLP
F
I
PHE
DPRIWDST
D
AL
E
L
KE
VPERLLV
M
G
G
G
I
IGLE
M
G
T
V
Y
HA
LGS
QI
D
V
VEM
F
D
QV
I
PA
A
D
KD
I
V
-K
V
FTK
R
IS
KK
FN
L
M
L
E
T
K
V
T
AVE
AK
E
---
DG
I
Y
V
T
-
ME
GKK
AP
A
E
PQ
R
Y
--
D
A
V
LVAIGRVPN
G
KN
LD
A
GKA
GVE
V
DDRG
F
I
R
VD
KQL
RTN
V
PHI
F
AIGD
I
VGQPMLAHK
G
VH
EG
H
VAAE
V
I
--
AG
K
K
H
YF
DP
---
KV
IPS
I
A
YT
E
PEVAWVG
L
TE
KE
AK
E
K
GI
S
YE
T
A
T
FP
W
A
AS
GRA
I
A
S
D
CAD
G
MT
KLIFDKES
H
RVIGGAIVG
TN
G
GEL
L
G
EI
G
LAIE
M
---
G
C
D
A
EDIA
L
TIHAHPTL
H
E
SVG
LAAEVFEGSITDLPNPKAKKK
fig|405955.13.peg.127
Escherichia coli APEC O1
MSTEIKTQV
V
V
L
G
A
GPAGY
S
AA
F
R
C
AD
L
GL
ET
VI
V
------
ERY
N
TLGG
V
CLNVGCIPSKALLH
V
A
KV
I
E
E
AKAL
A
E
-
HG
IVFGE
P
KT
D
I
D
K
I
R
TW
K
E
K
VINQL
-
T
G
G
LA
G
MA
KG
R
K
-
VKV
V
N
GL
GK
F
T
G
A
N
----
TL
E
VE
-
G
EN
G
KT
VI
N
FDN
A
I
IA
A
GSRP
I
--
QLP
F
I
PHE
DPRIWDST
D
AL
E
L
KE
VPERLLV
M
G
G
G
I
IGLE
M
G
T
V
Y
HA
LGS
QI
D
V
VEM
F
D
QV
I
PA
A
D
KD
I
V
-K
V
FTK
R
IS
KK
FN
L
M
L
E
T
K
V
T
AVE
AK
E
---
DG
I
Y
V
T
-
ME
GKK
AP
A
E
PQ
R
Y
--
D
A
V
LVAIGRVPN
G
KN
LD
A
GKA
GVE
V
DDRG
F
I
R
VD
KQL
RTN
V
PHI
F
AIGD
I
VGQPMLAHK
G
VH
EG
H
VAAE
V
I
--
AG
K
K
H
YF
DP
---
KV
IPS
I
A
YT
E
PEVAWVG
L
TE
KE
AK
E
K
GI
S
YE
T
A
T
FP
W
A
AS
GRA
I
A
S
D
CAD
G
MT
KLIFDKES
H
RVIGGAIVG
TN
G
GEL
L
G
EI
G
LAIE
M
---
G
C
D
A
EDIA
L
TIHAHPTL
H
E
SVG
LAAEVFEGSITDLPNPKAKKK
fig|550672.3.peg.4387
Escherichia coli B088
MSTEIKTQV
V
V
L
G
A
GPAGY
S
AA
F
R
C
AD
L
GL
ET
VI
V
------
ERY
N
TLGG
V
CLNVGCIPSKALLH
V
A
KV
I
E
E
AKAL
A
E
-
HG
IVFGE
P
KT
D
I
D
K
I
R
TW
K
E
K
VINQL
-
T
G
G
LA
G
MA
KG
R
K
-
VKV
V
N
GL
GK
F
T
G
A
N
----
TL
E
VE
-
G
EN
G
KT
VI
N
FDN
A
I
IA
A
GSRP
I
--
QLP
F
I
PHE
DPRIWDST
D
AL
E
L
KE
VPERLLV
M
G
G
G
I
IGLE
M
G
T
V
Y
HA
LGS
QI
D
V
VEM
F
D
QV
I
PA
A
D
KD
I
V
-K
V
FTK
R
IS
KK
FN
L
M
L
E
T
K
V
T
AVE
AK
E
---
DG
I
Y
V
T
-
ME
GKK
AP
A
E
PQ
R
Y
--
D
A
V
LVAIGRVPN
G
KN
LD
A
GKA
GVE
V
DDRG
F
I
R
VD
KQL
RTN
V
PHI
F
AIGD
I
VGQPMLAHK
G
VH
EG
H
VAAE
V
I
--
AG
K
K
H
YF
DP
---
KV
IPS
I
A
YT
E
PEVAWVG
L
TE
KE
AK
E
K
GI
S
YE
T
A
T
FP
W
A
AS
GRA
I
A
S
D
CAD
G
MT
KLIFDKES
H
RVIGGAIVG
TN
G
GEL
L
G
EI
G
LAIE
M
---
G
C
D
A
EDIA
L
TIHAHPTL
H
E
SVG
LAAEVFEGSITDLPNPKAKKK
fig|344601.3.peg.2566
Escherichia coli B171
MSTEIKTQV
V
V
L
G
A
GPAGY
S
AA
F
R
C
AD
L
GL
ET
VI
V
------
ERY
N
TLGG
V
CLNVGCIPSKALLH
V
A
KV
I
E
E
AKAL
A
E
-
HG
IVFGE
P
KT
D
I
D
K
I
R
TW
K
E
K
VINQL
-
T
G
G
LA
G
MA
KG
R
K
-
VKV
V
N
GL
GK
F
T
G
A
N
----
TL
E
VE
-
G
EN
G
KT
VI
N
FDN
A
I
IA
A
GSRP
I
--
QLP
F
I
PHE
DPRIWDST
D
AL
E
L
KE
VPERLLV
M
G
G
G
I
IGLE
M
G
T
V
Y
HA
LGS
QI
D
V
VEM
F
D
QV
I
PA
A
D
KD
I
V
-K
V
FTK
R
IS
KK
FN
L
M
L
E
T
K
V
T
AVE
AK
E
---
DG
I
Y
V
T
-
ME
GKK
AP
A
E
PQ
R
Y
--
D
A
V
LVAIGRVPN
G
KN
LD
A
GKA
GVE
V
DDRG
F
I
R
VD
KQL
RTN
V
PHI
F
AIGD
I
VGQPMLAHK
G
VH
EG
H
VAAE
V
I
--
AG
K
K
H
YF
DP
---
KV
IPS
I
A
YT
E
PEVAWVG
L
TE
KE
AK
E
K
GI
S
YE
T
A
T
FP
W
A
AS
GRA
I
A
S
D
CAD
G
MT
KLIFDKES
H
RVIGGAIVG
TN
G
GEL
L
G
EI
G
LAIE
M
---
G
C
D
A
EDIA
L
TIHAHPTL
H
E
SVG
LAAEVFEGSITDLPNPKAKKK
fig|340184.3.peg.1439
Escherichia coli B7A
MSTEIKTQV
V
V
L
G
A
GPAGY
S
AA
F
R
C
AD
L
GL
ET
VI
V
------
ERY
N
TLGG
V
CLNVGCIPSKALLH
V
A
KV
I
E
E
AKAL
A
E
-
HG
IVFGE
P
KT
D
I
D
K
I
R
TW
K
E
K
VINQL
-
T
G
G
LA
G
MA
KG
R
K
-
VKV
V
N
GL
GK
F
T
G
A
N
----
TL
E
VE
-
G
EN
G
KT
VI
N
FDN
A
I
IA
A
GSRP
I
--
QLP
F
I
PHE
DPRIWDST
D
AL
E
L
KE
VPERLLV
M
G
G
G
I
IGLE
M
G
T
V
Y
HA
LGS
QI
D
V
VEM
F
D
QV
I
PA
A
D
KD
I
V
-K
V
FTK
R
IS
KK
FN
L
M
L
E
T
K
V
T
AVE
AK
E
---
DG
I
Y
V
T
-
ME
GKK
AP
A
E
PQ
R
Y
--
D
A
V
LVAIGRVPN
G
KN
LD
A
GKA
GVE
V
DDRG
F
I
R
VD
KQL
RTN
V
PHI
F
AIGD
I
VGQPMLAHK
G
VH
EG
H
VAAE
V
I
--
AG
K
K
H
YF
DP
---
KV
IPS
I
A
YT
E
PEVAWVG
L
TE
KE
AK
E
K
GI
S
YE
T
A
T
FP
W
A
AS
GRA
I
A
S
D
CAD
G
MT
KLIFDKES
H
RVIGGAIVG
TN
G
GEL
L
G
EI
G
LAIE
M
---
G
C
D
A
EDIA
L
TIHAHPTL
H
E
SVG
LAAEVFEGSITDLPNPKAKKK
fig|340186.3.peg.4461
Escherichia coli E110019
MSTEIKTQV
V
V
L
G
A
GPAGY
S
AA
F
R
C
AD
L
GL
ET
VI
V
------
ERY
N
TLGG
V
CLNVGCIPSKALLH
V
A
KV
I
E
E
AKAL
A
E
-
HG
IVFGE
P
KT
D
I
D
K
I
R
TW
K
E
K
VINQL
-
T
G
G
LA
G
MA
KG
R
K
-
VKV
V
N
GL
GK
F
T
G
A
N
----
TL
E
VE
-
G
EN
G
KT
VI
N
FDN
A
I
IA
A
GSRP
I
--
QLP
F
I
PHE
DPRIWDST
D
AL
E
L
KE
VPERLLV
M
G
G
G
I
IGLE
M
G
T
V
Y
HA
LGS
QI
D
V
VEM
F
D
QV
I
PA
A
D
KD
I
V
-K
V
FTK
R
IS
KK
FN
L
M
L
E
T
K
V
T
AVE
AK
E
---
DG
I
Y
V
T
-
ME
GKK
AP
A
E
PQ
R
Y
--
D
A
V
LVAIGRVPN
G
KN
LD
A
GKA
GVE
V
DDRG
F
I
R
VD
KQL
RTN
V
PHI
F
AIGD
I
VGQPMLAHK
G
VH
EG
H
VAAE
V
I
--
AG
K
K
H
YF
DP
---
KV
IPS
I
A
YT
E
PEVAWVG
L
TE
KE
AK
E
K
GI
S
YE
T
A
T
FP
W
A
AS
GRA
I
A
S
D
CAD
G
MT
KLIFDKES
H
RVIGGAIVG
TN
G
GEL
L
G
EI
G
LAIE
M
---
G
C
D
A
EDIA
L
TIHAHPTL
H
E
SVG
LAAEVFEGSITDLPNPKAKKK
fig|340185.3.peg.1642
Escherichia coli E22
MSTEIKTQV
V
V
L
G
A
GPAGY
S
AA
F
R
C
AD
L
GL
ET
VI
V
------
ERY
N
TLGG
V
CLNVGCIPSKALLH
V
A
KV
I
E
E
AKAL
A
E
-
HG
IVFGE
P
KT
D
I
D
K
I
R
TW
K
E
K
VINQL
-
T
G
G
LA
G
MA
KG
R
K
-
VKV
V
N
GL
GK
F
T
G
A
N
----
TL
E
VE
-
G
EN
G
KT
VI
N
FDN
A
I
IA
A
GSRP
I
--
QLP
F
I
PHE
DPRIWDST
D
AL
E
L
KE
VPERLLV
M
G
G
G
I
IGLE
M
G
T
V
Y
HA
LGS
QI
D
V
VEM
F
D
QV
I
PA
A
D
KD
I
V
-K
V
FTK
R
IS
KK
FN
L
M
L
E
T
K
V
T
AVE
AK
E
---
DG
I
Y
V
T
-
ME
GKK
AP
A
E
PQ
R
Y
--
D
A
V
LVAIGRVPN
G
KN
LD
A
GKA
GVE
V
DDRG
F
I
R
VD
KQL
RTN
V
PHI
F
AIGD
I
VGQPMLAHK
G
VH
EG
H
VAAE
V
I
--
AG
K
K
H
YF
DP
---
KV
IPS
I
A
YT
E
PEVAWVG
L
TE
KE
AK
E
K
GI
S
YE
T
A
T
FP
W
A
AS
GRA
I
A
S
D
CAD
G
MT
KLIFDKES
H
RVIGGAIVG
TN
G
GEL
L
G
EI
G
LAIE
M
---
G
C
D
A
EDIA
L
TIHAHPTL
H
E
SVG
LAAEVFEGSITDLPNPKAKKK
fig|331111.3.peg.2687
Escherichia coli E24377A
MSTEIKTQV
V
V
L
G
A
GPAGY
S
AA
F
R
C
AD
L
GL
ET
VI
V
------
ERY
N
TLGG
V
CLNVGCIPSKALLH
V
A
KV
I
E
E
AKAL
A
E
-
HG
IVFGE
P
KT
D
I
D
K
I
R
TW
K
E
K
VINQL
-
T
G
G
LA
G
MA
KG
R
K
-
VKV
V
N
GL
GK
F
T
G
A
N
----
TL
E
VE
-
G
EN
G
KT
VI
N
FDN
A
I
IA
A
GSRP
I
--
QLP
F
I
PHE
DPRIWDST
D
AL
E
L
KE
VPERLLV
M
G
G
G
I
IGLE
M
G
T
V
Y
HA
LGS
QI
D
V
VEM
F
D
QV
I
PA
A
D
KD
I
V
-K
V
FTK
R
IS
KK
FN
L
M
L
E
T
K
V
T
AVE
AK
E
---
DG
I
Y
V
T
-
ME
GKK
AP
A
E
PQ
R
Y
--
D
A
V
LVAIGRVPN
G
KN
LD
A
GKA
GVE
V
DDRG
F
I
R
VD
KQL
RTN
V
PHI
F
AIGD
I
VGQPMLAHK
G
VH
EG
H
VAAE
V
I
--
AG
K
K
H
YF
DP
---
KV
IPS
I
A
YT
E
PEVAWVG
L
TE
KE
AK
E
K
GI
S
YE
T
A
T
FP
W
A
AS
GRA
I
A
S
D
CAD
G
MT
KLIFDKES
H
RVIGGAIVG
TN
G
GEL
L
G
EI
G
LAIE
M
---
G
C
D
A
EDIA
L
TIHAHPTL
H
E
SVG
LAAEVFEGSITDLPNPKAKKK
fig|340197.3.peg.4376
Escherichia coli F11
MSTEIKTQV
V
V
L
G
A
GPAGY
S
AA
F
R
C
AD
L
GL
ET
VI
V
------
ERY
N
TLGG
V
CLNVGCIPSKALLH
V
A
KV
I
E
E
AKAL
A
E
-
HG
IVFGE
P
KT
D
I
D
K
I
R
TW
K
E
K
VINQL
-
T
G
G
LA
G
MA
KG
R
K
-
VKV
V
N
GL
GK
F
T
G
A
N
----
TL
E
VE
-
G
EN
G
KT
VI
N
FDN
A
I
IA
A
GSRP
I
--
QLP
F
I
PHE
DPRIWDST
D
AL
E
L
KE
VPERLLV
M
G
G
G
I
IGLE
M
G
T
V
Y
HA
LGS
QI
D
V
VEM
F
D
QV
I
PA
A
D
KD
I
V
-K
V
FTK
R
IS
KK
FN
L
M
L
E
T
K
V
T
AVE
AK
E
---
DG
I
Y
V
T
-
ME
GKK
AP
A
E
PQ
R
Y
--
D
A
V
LVAIGRVPN
G
KN
LD
A
GKA
GVE
V
DDRG
F
I
R
VD
KQL
RTN
V
PHI
F
AIGD
I
VGQPMLAHK
G
VH
EG
H
VAAE
V
I
--
AG
K
K
H
YF
DP
---
KV
IPS
I
A
YT
E
PEVAWVG
L
TE
KE
AK
E
K
GI
S
YE
T
A
T
FP
W
A
AS
GRA
I
A
S
D
CAD
G
MT
KLIFDKES
H
RVIGGAIVG
TN
G
GEL
L
G
EI
G
LAIE
M
---
G
C
D
A
EDIA
L
TIHAHPTL
H
E
SVG
LAAEVFEGSITDLPNPKAKKK
fig|656379.3.peg.358
Escherichia coli FVEC1302
MSTEIKTQV
V
V
L
G
A
GPAGY
S
AA
F
R
C
AD
L
GL
ET
VI
V
------
ERY
N
TLGG
V
CLNVGCIPSKALLH
V
A
KV
I
E
E
AKAL
A
E
-
HG
IVFGE
P
KT
D
I
D
K
I
R
TW
K
E
K
VINQL
-
T
G
G
LA
G
MA
KG
R
K
-
VKV
V
N
GL
GK
F
T
G
A
N
----
TL
E
VE
-
G
EN
G
KT
VI
N
FDN
A
I
IA
A
GSRP
I
--
QLP
F
I
PHE
DPRIWDST
D
AL
E
L
KE
VPERLLV
M
G
G
G
I
IGLE
M
G
T
V
Y
HA
LGS
QI
D
V
VEM
F
D
QV
I
PA
A
D
KD
I
V
-K
V
FTK
R
IS
KK
FN
L
M
L
E
T
K
V
T
AVE
AK
E
---
DG
I
Y
V
T
-
ME
GKK
AP
A
E
PQ
R
Y
--
D
A
V
LVAIGRVPN
G
KN
LD
A
GKA
GVE
V
DDRG
F
I
R
VD
KQL
RTN
V
PHI
F
AIGD
I
VGQPMLAHK
G
VH
EG
H
VAAE
V
I
--
AG
K
K
H
YF
DP
---
KV
IPS
I
A
YT
E
PEVAWVG
L
TE
KE
AK
E
K
GI
S
YE
T
A
T
FP
W
A
AS
GRA
I
A
S
D
CAD
G
MT
KLIFDKES
H
RVIGGAIVG
TN
G
GEL
L
G
EI
G
LAIE
M
---
G
C
D
A
EDIA
L
TIHAHPTL
H
E
SVG
LAAEVFEGSITDLPNPKAKKK
fig|656380.3.peg.294
Escherichia coli FVEC1412
MSTEIKTQV
V
V
L
G
A
GPAGY
S
AA
F
R
C
AD
L
GL
ET
VI
V
------
ERY
N
TLGG
V
CLNVGCIPSKALLH
V
A
KV
I
E
E
AKAL
A
E
-
HG
IVFGE
P
KT
D
I
D
K
I
R
TW
K
E
K
VINQL
-
T
G
G
LA
G
MA
KG
R
K
-
VKV
V
N
GL
GK
F
T
G
A
N
----
TL
E
VE
-
G
EN
G
KT
VI
N
FDN
A
I
IA
A
GSRP
I
--
QLP
F
I
PHE
DPRIWDST
D
AL
E
L
KE
VPERLLV
M
G
G
G
I
IGLE
M
G
T
V
Y
HA
LGS
QI
D
V
VEM
F
D
QV
I
PA
A
D
KD
I
V
-K
V
FTK
R
IS
KK
FN
L
M
L
E
T
K
V
T
AVE
AK
E
---
DG
I
Y
V
T
-
ME
GKK
AP
A
E
PQ
R
Y
--
D
A
V
LVAIGRVPN
G
KN
LD
A
GKA
GVE
V
DDRG
F
I
R
VD
KQL
RTN
V
PHI
F
AIGD
I
VGQPMLAHK
G
VH
EG
H
VAAE
V
I
--
AG
K
K
H
YF
DP
---
KV
IPS
I
A
YT
E
PEVAWVG
L
TE
KE
AK
E
K
GI
S
YE
T
A
T
FP
W
A
AS
GRA
I
A
S
D
CAD
G
MT
KLIFDKES
H
RVIGGAIVG
TN
G
GEL
L
G
EI
G
LAIE
M
---
G
C
D
A
EDIA
L
TIHAHPTL
H
E
SVG
LAAEVFEGSITDLPNPKAKKK
fig|331112.3.peg.115
Escherichia coli HS
MSTEIKTQV
V
V
L
G
A
GPAGY
S
AA
F
R
C
AD
L
GL
ET
VI
V
------
ERY
N
TLGG
V
CLNVGCIPSKALLH
V
A
KV
I
E
E
AKAL
A
E
-
HG
IVFGE
P
KT
D
I
D
K
I
R
TW
K
E
K
VINQL
-
T
G
G
LA
G
MA
KG
R
K
-
VKV
V
N
GL
GK
F
T
G
A
N
----
TL
E
VE
-
G
EN
G
KT
VI
N
FDN
A
I
IA
A
GSRP
I
--
QLP
F
I
PHE
DPRIWDST
D
AL
E
L
KE
VPERLLV
M
G
G
G
I
IGLE
M
G
T
V
Y
HA
LGS
QI
D
V
VEM
F
D
QV
I
PA
A
D
KD
I
V
-K
V
FTK
R
IS
KK
FN
L
M
L
E
T
K
V
T
AVE
AK
E
---
DG
I
Y
V
T
-
ME
GKK
AP
A
E
PQ
R
Y
--
D
A
V
LVAIGRVPN
G
KN
LD
A
GKA
GVE
V
DDRG
F
I
R
VD
KQL
RTN
V
PHI
F
AIGD
I
VGQPMLAHK
G
VH
EG
H
VAAE
V
I
--
AG
K
K
H
YF
DP
---
KV
IPS
I
A
YT
E
PEVAWVG
L
TE
KE
AK
E
K
GI
S
YE
T
A
T
FP
W
A
AS
GRA
I
A
S
D
CAD
G
MT
KLIFDKES
H
RVIGGAIVG
TN
G
GEL
L
G
EI
G
LAIE
M
---
G
C
D
A
EDIA
L
TIHAHPTL
H
E
SVG
LAAEVFEGSITDLPNPKAKKK
fig|585057.4.peg.127
Escherichia coli IAI39
MSTEIKTQV
V
V
L
G
A
GPAGY
S
AA
F
R
C
AD
L
GL
ET
VI
V
------
ERY
N
TLGG
V
CLNVGCIPSKALLH
V
A
KV
I
E
E
AKAL
A
E
-
HG
IVFGE
P
KT
D
I
D
K
I
R
TW
K
E
K
VINQL
-
T
G
G
LA
G
MA
KG
R
K
-
VKV
V
N
GL
GK
F
T
G
A
N
----
TL
E
VE
-
G
EN
G
KT
VI
N
FDN
A
I
IA
A
GSRP
I
--
QLP
F
I
PHE
DPRIWDST
D
AL
E
L
KE
VPERLLV
M
G
G
G
I
IGLE
M
G
T
V
Y
HA
LGS
QI
D
V
VEM
F
D
QV
I
PA
A
D
KD
I
V
-K
V
FTK
R
IS
KK
FN
L
M
L
E
T
K
V
T
AVE
AK
E
---
DG
I
Y
V
T
-
ME
GKK
AP
A
E
PQ
R
Y
--
D
A
V
LVAIGRVPN
G
KN
LD
A
GKA
GVE
V
DDRG
F
I
R
VD
KQL
RTN
V
PHI
F
AIGD
I
VGQPMLAHK
G
VH
EG
H
VAAE
V
I
--
AG
K
K
H
YF
DP
---
KV
IPS
I
A
YT
E
PEVAWVG
L
TE
KE
AK
E
K
GI
S
YE
T
A
T
FP
W
A
AS
GRA
I
A
S
D
CAD
G
MT
KLIFDKES
H
RVIGGAIVG
TN
G
GEL
L
G
EI
G
LAIE
M
---
G
C
D
A
EDIA
L
TIHAHPTL
H
E
SVG
LAAEVFEGSITDLPNPKAKKK
fig|585057.6.peg.126
Escherichia coli IAI39
MSTEIKTQV
V
V
L
G
A
GPAGY
S
AA
F
R
C
AD
L
GL
ET
VI
V
------
ERY
N
TLGG
V
CLNVGCIPSKALLH
V
A
KV
I
E
E
AKAL
A
E
-
HG
IVFGE
P
KT
D
I
D
K
I
R
TW
K
E
K
VINQL
-
T
G
G
LA
G
MA
KG
R
K
-
VKV
V
N
GL
GK
F
T
G
A
N
----
TL
E
VE
-
G
EN
G
KT
VI
N
FDN
A
I
IA
A
GSRP
I
--
QLP
F
I
PHE
DPRIWDST
D
AL
E
L
KE
VPERLLV
M
G
G
G
I
IGLE
M
G
T
V
Y
HA
LGS
QI
D
V
VEM
F
D
QV
I
PA
A
D
KD
I
V
-K
V
FTK
R
IS
KK
FN
L
M
L
E
T
K
V
T
AVE
AK
E
---
DG
I
Y
V
T
-
ME
GKK
AP
A
E
PQ
R
Y
--
D
A
V
LVAIGRVPN
G
KN
LD
A
GKA
GVE
V
DDRG
F
I
R
VD
KQL
RTN
V
PHI
F
AIGD
I
VGQPMLAHK
G
VH
EG
H
VAAE
V
I
--
AG
K
K
H
YF
DP
---
KV
IPS
I
A
YT
E
PEVAWVG
L
TE
KE
AK
E
K
GI
S
YE
T
A
T
FP
W
A
AS
GRA
I
A
S
D
CAD
G
MT
KLIFDKES
H
RVIGGAIVG
TN
G
GEL
L
G
EI
G
LAIE
M
---
G
C
D
A
EDIA
L
TIHAHPTL
H
E
SVG
LAAEVFEGSITDLPNPKAKKK
fig|83333.1.peg.116
Escherichia coli K12
MSTEIKTQV
V
V
L
G
A
GPAGY
S
AA
F
R
C
AD
L
GL
ET
VI
V
------
ERY
N
TLGG
V
CLNVGCIPSKALLH
V
A
KV
I
E
E
AKAL
A
E
-
HG
IVFGE
P
KT
D
I
D
K
I
R
TW
K
E
K
VINQL
-
T
G
G
LA
G
MA
KG
R
K
-
VKV
V
N
GL
GK
F
T
G
A
N
----
TL
E
VE
-
G
EN
G
KT
VI
N
FDN
A
I
IA
A
GSRP
I
--
QLP
F
I
PHE
DPRIWDST
D
AL
E
L
KE
VPERLLV
M
G
G
G
I
IGLE
M
G
T
V
Y
HA
LGS
QI
D
V
VEM
F
D
QV
I
PA
A
D
KD
I
V
-K
V
FTK
R
IS
KK
FN
L
M
L
E
T
K
V
T
AVE
AK
E
---
DG
I
Y
V
T
-
ME
GKK
AP
A
E
PQ
R
Y
--
D
A
V
LVAIGRVPN
G
KN
LD
A
GKA
GVE
V
DDRG
F
I
R
VD
KQL
RTN
V
PHI
F
AIGD
I
VGQPMLAHK
G
VH
EG
H
VAAE
V
I
--
AG
K
K
H
YF
DP
---
KV
IPS
I
A
YT
E
PEVAWVG
L
TE
KE
AK
E
K
GI
S
YE
T
A
T
FP
W
A
AS
GRA
I
A
S
D
CAD
G
MT
KLIFDKES
H
RVIGGAIVG
TN
G
GEL
L
G
EI
G
LAIE
M
---
G
C
D
A
EDIA
L
TIHAHPTL
H
E
SVG
LAAEVFEGSITDLPNPKAKKK
fig|749537.3.peg.3214
Escherichia coli MS 115-1
MSTEIKTQV
V
V
L
G
A
GPAGY
S
AA
F
R
C
AD
L
GL
ET
VI
V
------
ERY
N
TLGG
V
CLNVGCIPSKALLH
V
A
KV
I
E
E
AKAL
A
E
-
HG
IVFGE
P
KT
D
I
D
K
I
R
TW
K
E
K
VINQL
-
T
G
G
LA
G
MA
KG
R
K
-
VKV
V
N
GL
GK
F
T
G
A
N
----
TL
E
VE
-
G
EN
G
KT
VI
N
FDN
A
I
IA
A
GSRP
I
--
QLP
F
I
PHE
DPRIWDST
D
AL
E
L
KE
VPERLLV
M
G
G
G
I
IGLE
M
G
T
V
Y
HA
LGS
QI
D
V
VEM
F
D
QV
I
PA
A
D
KD
I
V
-K
V
FTK
R
IS
KK
FN
L
M
L
E
T
K
V
T
AVE
AK
E
---
DG
I
Y
V
T
-
ME
GKK
AP
A
E
PQ
R
Y
--
D
A
V
LVAIGRVPN
G
KN
LD
A
GKA
GVE
V
DDRG
F
I
R
VD
KQL
RTN
V
PHI
F
AIGD
I
VGQPMLAHK
G
VH
EG
H
VAAE
V
I
--
AG
K
K
H
YF
DP
---
KV
IPS
I
A
YT
E
PEVAWVG
L
TE
KE
AK
E
K
GI
S
YE
T
A
T
FP
W
A
AS
GRA
I
A
S
D
CAD
G
MT
KLIFDKES
H
RVIGGAIVG
TN
G
GEL
L
G
EI
G
LAIE
M
---
G
C
D
A
EDIA
L
TIHAHPTL
H
E
SVG
LAAEVFEGSITDLPNPKAKKK
fig|574521.7.peg.123
Escherichia coli O127:H6 str. E2348/69
MSTEIKTQV
V
V
L
G
A
GPAGY
S
AA
F
R
C
AD
L
GL
ET
VI
V
------
ERY
N
TLGG
V
CLNVGCIPSKALLH
V
A
KV
I
E
E
AKAL
A
E
-
HG
IVFGE
P
KT
D
I
D
K
I
R
TW
K
E
K
VINQL
-
T
G
G
LA
G
MA
KG
R
K
-
VKV
V
N
GL
GK
F
T
G
A
N
----
TL
E
VE
-
G
EN
G
KT
VI
N
FDN
A
I
IA
A
GSRP
I
--
QLP
F
I
PHE
DPRIWDST
D
AL
E
L
KE
VPERLLV
M
G
G
G
I
IGLE
M
G
T
V
Y
HA
LGS
QI
D
V
VEM
F
D
QV
I
PA
A
D
KD
I
V
-K
V
FTK
R
IS
KK
FN
L
M
L
E
T
K
V
T
AVE
AK
E
---
DG
I
Y
V
T
-
ME
GKK
AP
A
E
PQ
R
Y
--
D
A
V
LVAIGRVPN
G
KN
LD
A
GKA
GVE
V
DDRG
F
I
R
VD
KQL
RTN
V
PHI
F
AIGD
I
VGQPMLAHK
G
VH
EG
H
VAAE
V
I
--
AG
K
K
H
YF
DP
---
KV
IPS
I
A
YT
E
PEVAWVG
L
TE
KE
AK
E
K
GI
S
YE
T
A
T
FP
W
A
AS
GRA
I
A
S
D
CAD
G
MT
KLIFDKES
H
RVIGGAIVG
TN
G
GEL
L
G
EI
G
LAIE
M
---
G
C
D
A
EDIA
L
TIHAHPTL
H
E
SVG
LAAEVFEGSITDLPNPKAKKK
fig|83334.1.peg.207
Escherichia coli O157:H7
MSTEIKTQV
V
V
L
G
A
GPAGY
S
AA
F
R
C
AD
L
GL
ET
VI
V
------
ERY
N
TLGG
V
CLNVGCIPSKALLH
V
A
KV
I
E
E
AKAL
A
E
-
HG
IVFGE
P
KT
D
I
D
K
I
R
TW
K
E
K
VINQL
-
T
G
G
LA
G
MA
KG
R
K
-
VKV
V
N
GL
GK
F
T
G
A
N
----
TL
E
VE
-
G
EN
G
KT
VI
N
FDN
A
I
IA
A
GSRP
I
--
QLP
F
I
PHE
DPRIWDST
D
AL
E
L
KE
VPERLLV
M
G
G
G
I
IGLE
M
G
T
V
Y
HA
LGS
QI
D
V
VEM
F
D
QV
I
PA
A
D
KD
I
V
-K
V
FTK
R
IS
KK
FN
L
M
L
E
T
K
V
T
AVE
AK
E
---
DG
I
Y
V
T
-
ME
GKK
AP
A
E
PQ
R
Y
--
D
A
V
LVAIGRVPN
G
KN
LD
A
GKA
GVE
V
DDRG
F
I
R
VD
KQL
RTN
V
PHI
F
AIGD
I
VGQPMLAHK
G
VH
EG
H
VAAE
V
I
--
AG
K
K
H
YF
DP
---
KV
IPS
I
A
YT
E
PEVAWVG
L
TE
KE
AK
E
K
GI
S
YE
T
A
T
FP
W
A
AS
GRA
I
A
S
D
CAD
G
MT
KLIFDKES
H
RVIGGAIVG
TN
G
GEL
L
G
EI
G
LAIE
M
---
G
C
D
A
EDIA
L
TIHAHPTL
H
E
SVG
LAAEVFEGSITDLPNPKAKKK
fig|155864.1.peg.120
Escherichia coli O157:H7 EDL933
MSTEIKTQV
V
V
L
G
A
GPAGY
S
AA
F
R
C
AD
L
GL
ET
VI
V
------
ERY
N
TLGG
V
CLNVGCIPSKALLH
V
A
KV
I
E
E
AKAL
A
E
-
HG
IVFGE
P
KT
D
I
D
K
I
R
TW
K
E
K
VINQL
-
T
G
G
LA
G
MA
KG
R
K
-
VKV
V
N
GL
GK
F
T
G
A
N
----
TL
E
VE
-
G
EN
G
KT
VI
N
FDN
A
I
IA
A
GSRP
I
--
QLP
F
I
PHE
DPRIWDST
D
AL
E
L
KE
VPERLLV
M
G
G
G
I
IGLE
M
G
T
V
Y
HA
LGS
QI
D
V
VEM
F
D
QV
I
PA
A
D
KD
I
V
-K
V
FTK
R
IS
KK
FN
L
M
L
E
T
K
V
T
AVE
AK
E
---
DG
I
Y
V
T
-
ME
GKK
AP
A
E
PQ
R
Y
--
D
A
V
LVAIGRVPN
G
KN
LD
A
GKA
GVE
V
DDRG
F
I
R
VD
KQL
RTN
V
PHI
F
AIGD
I
VGQPMLAHK
G
VH
EG
H
VAAE
V
I
--
AG
K
K
H
YF
DP
---
KV
IPS
I
A
YT
E
PEVAWVG
L
TE
KE
AK
E
K
GI
S
YE
T
A
T
FP
W
A
AS
GRA
I
A
S
D
CAD
G
MT
KLIFDKES
H
RVIGGAIVG
TN
G
GEL
L
G
EI
G
LAIE
M
---
G
C
D
A
EDIA
L
TIHAHPTL
H
E
SVG
LAAEVFEGSITDLPNPKAKKK
fig|478005.5.peg.4214
Escherichia coli O157:H7 str. EC4486
MSTEIKTQV
V
V
L
G
A
GPAGY
S
AA
F
R
C
AD
L
GL
ET
VI
V
------
ERY
N
TLGG
V
CLNVGCIPSKALLH
V
A
KV
I
E
E
AKAL
A
E
-
HG
IVFGE
P
KT
D
I
D
K
I
R
TW
K
E
K
VINQL
-
T
G
G
LA
G
MA
KG
R
K
-
VKV
V
N
GL
GK
F
T
G
A
N
----
TL
E
VE
-
G
EN
G
KT
VI
N
FDN
A
I
IA
A
GSRP
I
--
QLP
F
I
PHE
DPRIWDST
D
AL
E
L
KE
VPERLLV
M
G
G
G
I
IGLE
M
G
T
V
Y
HA
LGS
QI
D
V
VEM
F
D
QV
I
PA
A
D
KD
I
V
-K
V
FTK
R
IS
KK
FN
L
M
L
E
T
K
V
T
AVE
AK
E
---
DG
I
Y
V
T
-
ME
GKK
AP
A
E
PQ
R
Y
--
D
A
V
LVAIGRVPN
G
KN
LD
A
GKA
GVE
V
DDRG
F
I
R
VD
KQL
RTN
V
PHI
F
AIGD
I
VGQPMLAHK
G
VH
EG
H
VAAE
V
I
--
AG
K
K
H
YF
DP
---
KV
IPS
I
A
YT
E
PEVAWVG
L
TE
KE
AK
E
K
GI
S
YE
T
A
T
FP
W
A
AS
GRA
I
A
S
D
CAD
G
MT
KLIFDKES
H
RVIGGAIVG
TN
G
GEL
L
G
EI
G
LAIE
M
---
G
C
D
A
EDIA
L
TIHAHPTL
H
E
SVG
LAAEVFEGSITDLPNPKAKKK
fig|585035.6.peg.129
Escherichia coli S88
MSTEIKTQV
V
V
L
G
A
GPAGY
S
AA
F
R
C
AD
L
GL
ET
VI
V
------
ERY
N
TLGG
V
CLNVGCIPSKALLH
V
A
KV
I
E
E
AKAL
A
E
-
HG
IVFGE
P
KT
D
I
D
K
I
R
TW
K
E
K
VINQL
-
T
G
G
LA
G
MA
KG
R
K
-
VKV
V
N
GL
GK
F
T
G
A
N
----
TL
E
VE
-
G
EN
G
KT
VI
N
FDN
A
I
IA
A
GSRP
I
--
QLP
F
I
PHE
DPRIWDST
D
AL
E
L
KE
VPERLLV
M
G
G
G
I
IGLE
M
G
T
V
Y
HA
LGS
QI
D
V
VEM
F
D
QV
I
PA
A
D
KD
I
V
-K
V
FTK
R
IS
KK
FN
L
M
L
E
T
K
V
T
AVE
AK
E
---
DG
I
Y
V
T
-
ME
GKK
AP
A
E
PQ
R
Y
--
D
A
V
LVAIGRVPN
G
KN
LD
A
GKA
GVE
V
DDRG
F
I
R
VD
KQL
RTN
V
PHI
F
AIGD
I
VGQPMLAHK
G
VH
EG
H
VAAE
V
I
--
AG
K
K
H
YF
DP
---
KV
IPS
I
A
YT
E
PEVAWVG
L
TE
KE
AK
E
K
GI
S
YE
T
A
T
FP
W
A
AS
GRA
I
A
S
D
CAD
G
MT
KLIFDKES
H
RVIGGAIVG
TN
G
GEL
L
G
EI
G
LAIE
M
---
G
C
D
A
EDIA
L
TIHAHPTL
H
E
SVG
LAAEVFEGSITDLPNPKAKKK
fig|439855.10.peg.299
Escherichia coli SMS-3-5
MSTEIKTQV
V
V
L
G
A
GPAGY
S
AA
F
R
C
AD
L
GL
ET
VI
V
------
ERY
N
TLGG
V
CLNVGCIPSKALLH
V
A
KV
I
E
E
AKAL
A
E
-
HG
IVFGE
P
KT
D
I
D
K
I
R
TW
K
E
K
VINQL
-
T
G
G
LA
G
MA
KG
R
K
-
VKV
V
N
GL
GK
F
T
G
A
N
----
TL
E
VE
-
G
EN
G
KT
VI
N
FDN
A
I
IA
A
GSRP
I
--
QLP
F
I
PHE
DPRIWDST
D
AL
E
L
KE
VPERLLV
M
G
G
G
I
IGLE
M
G
T
V
Y
HA
LGS
QI
D
V
VEM
F
D
QV
I
PA
A
D
KD
I
V
-K
V
FTK
R
IS
KK
FN
L
M
L
E
T
K
V
T
AVE
AK
E
---
DG
I
Y
V
T
-
ME
GKK
AP
A
E
PQ
R
Y
--
D
A
V
LVAIGRVPN
G
KN
LD
A
GKA
GVE
V
DDRG
F
I
R
VD
KQL
RTN
V
PHI
F
AIGD
I
VGQPMLAHK
G
VH
EG
H
VAAE
V
I
--
AG
K
K
H
YF
DP
---
KV
IPS
I
A
YT
E
PEVAWVG
L
TE
KE
AK
E
K
GI
S
YE
T
A
T
FP
W
A
AS
GRA
I
A
S
D
CAD
G
MT
KLIFDKES
H
RVIGGAIVG
TN
G
GEL
L
G
EI
G
LAIE
M
---
G
C
D
A
EDIA
L
TIHAHPTL
H
E
SVG
LAAEVFEGSITDLPNPKAKKK
fig|656437.3.peg.181
Escherichia coli TA143
MSTEIKTQV
V
V
L
G
A
GPAGY
S
AA
F
R
C
AD
L
GL
ET
VI
V
------
ERY
N
TLGG
V
CLNVGCIPSKALLH
V
A
KV
I
E
E
AKAL
A
E
-
HG
IVFGE
P
KT
D
I
D
K
I
R
TW
K
E
K
VINQL
-
T
G
G
LA
G
MA
KG
R
K
-
VKV
V
N
GL
GK
F
T
G
A
N
----
TL
E
VE
-
G
EN
G
KT
VI
N
FDN
A
I
IA
A
GSRP
I
--
QLP
F
I
PHE
DPRIWDST
D
AL
E
L
KE
VPERLLV
M
G
G
G
I
IGLE
M
G
T
V
Y
HA
LGS
QI
D
V
VEM
F
D
QV
I
PA
A
D
KD
I
V
-K
V
FTK
R
IS
KK
FN
L
M
L
E
T
K
V
T
AVE
AK
E
---
DG
I
Y
V
T
-
ME
GKK
AP
A
E
PQ
R
Y
--
D
A
V
LVAIGRVPN
G
KN
LD
A
GKA
GVE
V
DDRG
F
I
R
VD
KQL
RTN
V
PHI
F
AIGD
I
VGQPMLAHK
G
VH
EG
H
VAAE
V
I
--
AG
K
K
H
YF
DP
---
KV
IPS
I
A
YT
E
PEVAWVG
L
TE
KE
AK
E
K
GI
S
YE
T
A
T
FP
W
A
AS
GRA
I
A
S
D
CAD
G
MT
KLIFDKES
H
RVIGGAIVG
TN
G
GEL
L
G
EI
G
LAIE
M
---
G
C
D
A
EDIA
L
TIHAHPTL
H
E
SVG
LAAEVFEGSITDLPNPKAKKK
fig|585056.7.peg.305
Escherichia coli UMN026
MSTEIKTQV
V
V
L
G
A
GPAGY
S
AA
F
R
C
AD
L
GL
ET
VI
V
------
ERY
N
TLGG
V
CLNVGCIPSKALLH
V
A
KV
I
E
E
AKAL
A
E
-
HG
IVFGE
P
KT
D
I
D
K
I
R
TW
K
E
K
VINQL
-
T
G
G
LA
G
MA
KG
R
K
-
VKV
V
N
GL
GK
F
T
G
A
N
----
TL
E
VE
-
G
EN
G
KT
VI
N
FDN
A
I
IA
A
GSRP
I
--
QLP
F
I
PHE
DPRIWDST
D
AL
E
L
KE
VPERLLV
M
G
G
G
I
IGLE
M
G
T
V
Y
HA
LGS
QI
D
V
VEM
F
D
QV
I
PA
A
D
KD
I
V
-K
V
FTK
R
IS
KK
FN
L
M
L
E
T
K
V
T
AVE
AK
E
---
DG
I
Y
V
T
-
ME
GKK
AP
A
E
PQ
R
Y
--
D
A
V
LVAIGRVPN
G
KN
LD
A
GKA
GVE
V
DDRG
F
I
R
VD
KQL
RTN
V
PHI
F
AIGD
I
VGQPMLAHK
G
VH
EG
H
VAAE
V
I
--
AG
K
K
H
YF
DP
---
KV
IPS
I
A
YT
E
PEVAWVG
L
TE
KE
AK
E
K
GI
S
YE
T
A
T
FP
W
A
AS
GRA
I
A
S
D
CAD
G
MT
KLIFDKES
H
RVIGGAIVG
TN
G
GEL
L
G
EI
G
LAIE
M
---
G
C
D
A
EDIA
L
TIHAHPTL
H
E
SVG
LAAEVFEGSITDLPNPKAKKK
fig|316407.3.peg.113
Escherichia coli W3110
MSTEIKTQV
V
V
L
G
A
GPAGY
S
AA
F
R
C
AD
L
GL
ET
VI
V
------
ERY
N
TLGG
V
CLNVGCIPSKALLH
V
A
KV
I
E
E
AKAL
A
E
-
HG
IVFGE
P
KT
D
I
D
K
I
R
TW
K
E
K
VINQL
-
T
G
G
LA
G
MA
KG
R
K
-
VKV
V
N
GL
GK
F
T
G
A
N
----
TL
E
VE
-
G
EN
G
KT
VI
N
FDN
A
I
IA
A
GSRP
I
--
QLP
F
I
PHE
DPRIWDST
D
AL
E
L
KE
VPERLLV
M
G
G
G
I
IGLE
M
G
T
V
Y
HA
LGS
QI
D
V
VEM
F
D
QV
I
PA
A
D
KD
I
V
-K
V
FTK
R
IS
KK
FN
L
M
L
E
T
K
V
T
AVE
AK
E
---
DG
I
Y
V
T
-
ME
GKK
AP
A
E
PQ
R
Y
--
D
A
V
LVAIGRVPN
G
KN
LD
A
GKA
GVE
V
DDRG
F
I
R
VD
KQL
RTN
V
PHI
F
AIGD
I
VGQPMLAHK
G
VH
EG
H
VAAE
V
I
--
AG
K
K
H
YF
DP
---
KV
IPS
I
A
YT
E
PEVAWVG
L
TE
KE
AK
E
K
GI
S
YE
T
A
T
FP
W
A
AS
GRA
I
A
S
D
CAD
G
MT
KLIFDKES
H
RVIGGAIVG
TN
G
GEL
L
G
EI
G
LAIE
M
---
G
C
D
A
EDIA
L
TIHAHPTL
H
E
SVG
LAAEVFEGSITDLPNPKAKKK
fig|316385.5.peg.96
Escherichia coli str. K-12 substr. DH10B
MSTEIKTQV
V
V
L
G
A
GPAGY
S
AA
F
R
C
AD
L
GL
ET
VI
V
------
ERY
N
TLGG
V
CLNVGCIPSKALLH
V
A
KV
I
E
E
AKAL
A
E
-
HG
IVFGE
P
KT
D
I
D
K
I
R
TW
K
E
K
VINQL
-
T
G
G
LA
G
MA
KG
R
K
-
VKV
V
N
GL
GK
F
T
G
A
N
----
TL
E
VE
-
G
EN
G
KT
VI
N
FDN
A
I
IA
A
GSRP
I
--
QLP
F
I
PHE
DPRIWDST
D
AL
E
L
KE
VPERLLV
M
G
G
G
I
IGLE
M
G
T
V
Y
HA
LGS
QI
D
V
VEM
F
D
QV
I
PA
A
D
KD
I
V
-K
V
FTK
R
IS
KK
FN
L
M
L
E
T
K
V
T
AVE
AK
E
---
DG
I
Y
V
T
-
ME
GKK
AP
A
E
PQ
R
Y
--
D
A
V
LVAIGRVPN
G
KN
LD
A
GKA
GVE
V
DDRG
F
I
R
VD
KQL
RTN
V
PHI
F
AIGD
I
VGQPMLAHK
G
VH
EG
H
VAAE
V
I
--
AG
K
K
H
YF
DP
---
KV
IPS
I
A
YT
E
PEVAWVG
L
TE
KE
AK
E
K
GI
S
YE
T
A
T
FP
W
A
AS
GRA
I
A
S
D
CAD
G
MT
KLIFDKES
H
RVIGGAIVG
TN
G
GEL
L
G
EI
G
LAIE
M
---
G
C
D
A
EDIA
L
TIHAHPTL
H
E
SVG
LAAEVFEGSITDLPNPKAKKK
fig|344610.3.peg.4018
Escherichia coli 53638
MSTEIKTQV
V
V
L
G
A
GPAGY
S
AA
F
R
C
AD
L
GL
ET
VI
V
------
ERY
N
TLGG
V
CLNVGCIPSKALLH
V
A
KV
I
E
E
AKAL
A
E
-
HG
IVFGE
P
KT
D
I
D
K
I
R
TW
K
E
K
VINQL
-
T
G
G
LA
G
MA
KG
R
K
-
VKV
V
N
GL
GK
F
T
G
A
N
----
TL
E
VE
-
G
EN
G
KT
VI
N
FDN
A
I
IA
A
GSRP
I
--
QLP
F
I
PHE
DPRIWDST
D
AL
E
L
KE
VPERLLV
M
G
G
G
I
IGLE
M
G
T
V
Y
HA
LGS
QI
D
V
VEM
F
D
QV
I
PA
A
D
KD
I
V
-K
V
FTK
R
IS
KK
FN
L
M
L
E
T
K
V
T
AVE
AK
E
---
DG
I
Y
V
T
-
ME
GKK
AP
A
E
PQ
R
Y
--
D
A
V
LVAIGRVPN
G
KN
LD
A
GKA
GVE
V
DDRG
F
I
R
VD
KQL
RTN
V
PHI
F
AIGD
I
VGQPMLAHK
G
VH
EG
H
VAAE
V
I
--
AG
K
K
H
YF
DP
---
KV
IPS
I
A
YT
E
PEVAWVG
L
TE
KE
AK
E
K
GI
S
F
E
T
A
T
FP
W
A
AS
GRA
I
A
S
D
CAD
G
MT
KLIFDKES
H
RVIGGAIVG
TN
G
GEL
L
G
EI
G
LAIE
M
---
G
C
D
A
EDIA
L
TIHAHPTL
H
E
SVG
LAAEVFEGSITDLPNPKAKKK
fig|405955.13.peg.4537
Escherichia coli APEC O1 (7-462/472)
V
A
V
M
G
G
GP
G
GY
V
AA
L
R
A
A
QN
GL
S
VV
C
I
DDG
VNA
QGE
P
S
P
GG
T
CLNVGCIPSK
S
LL
Q
SS
EL
Y
A
Q
VQHE
A
S
I
HG
VNVEG
V
SF
N
A
A
A
M
I
QR
KD
A
IVSR
L
-
T
M
G
IS
L
LF
K
K
NK
-
VK
H
L
C
GLA
TL
E
R
A
Q
DEIW
Q
L
R
V
N
-
D
QH-
--
-
I
H
A
R
N
V
VIA
T
GS
Q
P
R
--
QLP
G
V
TID
N
QQ
I
L
D
N
R
G
AL
A
L
SE
VP
P
RL
G
V
I
GAGVIGLE
L
GSV
W
NR
V
GS
D
V
T
L
L
EM
A
P
TF
LPAL
E
AR
L
S
NE
V
RKA
M
I
A
SG
MK
M
Q
L
A
V
E
I
EA
I
E
QR
D
---
DGV
H
V
R
W
RQ
G
E
K
--
R
E
ES
R
F
--
D
K
L
IL
AIGRVP
RL
SG
V
DL
VQL
G
L
E
A
D
N
RG
G
I
A
VD
NLC
RT
G
K
A
G
LW
AIGDVV
R
G
PMLAHKA
MA
EG
V
V
V
A
D
Q
I
--
AG
LA-
-V
E
P
I
NF
AL
IPS
V
IYT
Q
PEVAWVG
E
N
E
AS
L
KA
A
G
R
V
FN
K
G
N
SL
FA
GN
GRA
L
A
L
G
QEG
G
RC
T
L
Y
S
DK
HT
D
RV
L
GGAIVG
PQ
A
S
ELI
N
EI
A
LA
MT
F
---
S
A
S
G
EDIA
C
A
IHAHPTL
S
E
VIH
E
AA
fig|405955.9.peg.3828
Escherichia coli APEC O1 (7-462/472)
V
A
V
M
G
G
GP
G
GY
V
AA
L
R
A
A
QN
GL
S
VV
C
I
DDG
VNA
QGE
P
S
P
GG
T
CLNVGCIPSK
S
LL
Q
SS
EL
Y
A
Q
VQHE
A
S
I
HG
VNVEG
V
SF
N
A
A
A
M
I
QR
KD
A
IVSR
L
-
T
M
G
IS
L
LF
K
K
NK
-
VK
H
L
C
GLA
TL
E
R
A
Q
DEIW
Q
L
R
V
N
-
D
QH-
--
-
I
H
A
R
N
V
VIA
T
GS
Q
P
R
--
QLP
G
V
TID
N
QQ
I
L
D
N
R
G
AL
A
L
SE
VP
P
RL
G
V
I
GAGVIGLE
L
GSV
W
NR
V
GS
D
V
T
L
L
EM
A
P
TF
LPAL
E
AR
L
S
NE
V
RKA
M
I
A
SG
MK
M
Q
L
A
V
E
I
EA
I
E
QR
D
---
DGV
H
V
R
W
RQ
G
E
K
--
R
E
ES
R
F
--
D
K
L
IL
AIGRVP
RL
SG
V
DL
VQL
G
L
E
A
D
N
RG
G
I
A
VD
NLC
RT
G
K
A
G
LW
AIGDVV
R
G
PMLAHKA
MA
EG
V
V
V
A
D
Q
I
--
AG
LA-
-V
E
P
I
NF
AL
IPS
V
IYT
Q
PEVAWVG
E
N
E
AS
L
KA
A
G
R
V
FN
K
G
N
SL
FA
GN
GRA
L
A
L
G
QEG
G
RC
T
L
Y
S
DK
HT
D
RV
L
GGAIVG
PQ
A
S
ELI
N
EI
A
LA
MT
F
---
S
A
S
G
EDIA
C
A
IHAHPTL
S
E
VIH
E
AA
fig|714962.3.peg.4575
Escherichia coli IHE3034 (7-462/472)
V
A
V
M
G
G
GP
G
GY
V
AA
L
R
A
A
QN
GL
S
VV
C
I
DDG
VNA
QGE
P
S
P
GG
T
CLNVGCIPSK
S
LL
Q
SS
EL
Y
A
Q
VQHE
A
S
I
HG
VNVEG
V
SF
N
A
A
A
M
I
QR
KD
A
IVSR
L
-
T
M
G
IS
L
LF
K
K
NK
-
VK
H
L
C
GLA
TL
E
R
A
Q
DEIW
Q
L
R
V
N
-
D
QH-
--
-
I
H
A
R
N
V
VIA
T
GS
Q
P
R
--
QLP
G
V
TID
N
QQ
I
L
D
N
R
G
AL
A
L
SE
VP
P
RL
G
V
I
GAGVIGLE
L
GSV
W
NR
V
GS
D
V
T
L
L
EM
A
P
TF
LPAL
E
AR
L
S
NE
V
RKA
M
I
A
SG
MK
M
Q
L
A
V
E
I
EA
I
E
QR
D
---
DGV
H
V
R
W
RQ
G
E
K
--
R
E
ES
R
F
--
D
K
L
IL
AIGRVP
RL
SG
V
DL
VQL
G
L
E
A
D
N
RG
G
I
A
VD
NLC
RT
G
K
A
G
LW
AIGDVV
R
G
PMLAHKA
MA
EG
V
V
V
A
D
Q
I
--
AG
LA-
-V
E
P
I
NF
AL
IPS
V
IYT
Q
PEVAWVG
E
N
E
AS
L
KA
A
G
R
V
FN
K
G
N
SL
FA
GN
GRA
L
A
L
G
QEG
G
RC
T
L
Y
S
DK
HT
D
RV
L
GGAIVG
PQ
A
S
ELI
N
EI
A
LA
MT
F
---
S
A
S
G
EDIA
C
A
IHAHPTL
S
E
VIH
E
AA
fig|585035.6.peg.4435
Escherichia coli S88 (7-462/472)
V
A
V
M
G
G
GP
G
GY
V
AA
L
R
A
A
QN
GL
S
VV
C
I
DDG
VNA
QGE
P
S
P
GG
T
CLNVGCIPSK
S
LL
Q
SS
EL
Y
A
Q
VQHE
A
S
I
HG
VNVEG
V
SF
N
A
A
A
M
I
QR
KD
A
IVSR
L
-
T
M
G
IS
L
LF
K
K
NK
-
VK
H
L
C
GLA
TL
E
R
A
Q
DEIW
Q
L
R
V
N
-
D
QH-
--
-
I
H
A
R
N
V
VIA
T
GS
Q
P
R
--
QLP
G
V
TID
N
QQ
I
L
D
N
R
G
AL
A
L
SE
VP
P
RL
G
V
I
GAGVIGLE
L
GSV
W
NR
V
GS
D
V
T
L
L
EM
A
P
TF
LPAL
E
AR
L
S
NE
V
RKA
M
I
A
SG
MK
M
Q
L
A
V
E
I
EA
I
E
QR
D
---
DGV
H
V
R
W
RQ
G
E
K
--
R
E
ES
R
F
--
D
K
L
IL
AIGRVP
RL
SG
V
DL
VQL
G
L
E
A
D
N
RG
G
I
A
VD
NLC
RT
G
K
A
G
LW
AIGDVV
R
G
PMLAHKA
MA
EG
V
V
V
A
D
Q
I
--
AG
LA-
-V
E
P
I
NF
AL
IPS
V
IYT
Q
PEVAWVG
E
N
E
AS
L
KA
A
G
R
V
FN
K
G
N
SL
FA
GN
GRA
L
A
L
G
QEG
G
RC
T
L
Y
S
DK
HT
D
RV
L
GGAIVG
PQ
A
S
ELI
N
EI
A
LA
MT
F
---
S
A
S
G
EDIA
C
A
IHAHPTL
S
E
VIH
E
AA
fig|869729.3.peg.4386
Escherichia coli UM146 (7-462/472)
V
A
V
M
G
G
GP
G
GY
V
AA
L
R
A
A
QN
GL
S
VV
C
I
DDG
VNA
QGE
P
S
P
GG
T
CLNVGCIPSK
S
LL
Q
SS
EL
Y
A
Q
VQHE
A
S
I
HG
VNVEG
V
SF
N
A
A
A
M
I
QR
KD
A
IVSR
L
-
T
M
G
IS
L
LF
K
K
NK
-
VK
H
L
C
GLA
TL
E
R
A
Q
DEIW
Q
L
R
V
N
-
D
QH-
--
-
I
H
A
R
N
V
VIA
T
GS
Q
P
R
--
QLP
G
V
TID
N
QQ
I
L
D
N
R
G
AL
A
L
SE
VP
P
RL
G
V
I
GAGVIGLE
L
GSV
W
NR
V
GS
D
V
T
L
L
EM
A
P
TF
LPAL
E
AR
L
S
NE
V
RKA
M
I
A
SG
MK
M
Q
L
A
V
E
I
EA
I
E
QR
D
---
DGV
H
V
R
W
RQ
G
E
K
--
R
E
ES
R
F
--
D
K
L
IL
AIGRVP
RL
SG
V
DL
VQL
G
L
E
A
D
N
RG
G
I
A
VD
NLC
RT
G
K
A
G
LW
AIGDVV
R
G
PMLAHKA
MA
EG
V
V
V
A
D
Q
I
--
AG
LA-
-V
E
P
I
NF
AL
IPS
V
IYT
Q
PEVAWVG
E
N
E
AS
L
KA
A
G
R
V
FN
K
G
N
SL
FA
GN
GRA
L
A
L
G
QEG
G
RC
T
L
Y
S
DK
HT
D
RV
L
GGAIVG
PQ
A
S
ELI
N
EI
A
LA
MT
F
---
S
A
S
G
EDIA
C
A
IHAHPTL
S
E
VIH
E
AA
fig|364106.7.peg.4511
Escherichia coli UTI89 (7-462/472)
V
A
V
M
G
G
GP
G
GY
V
AA
L
R
A
A
QN
GL
S
VV
C
I
DDG
VNA
QGE
P
S
P
GG
T
CLNVGCIPSK
S
LL
Q
SS
EL
Y
A
Q
VQHE
A
S
I
HG
VNVEG
V
SF
N
A
A
A
M
I
QR
KD
A
IVSR
L
-
T
M
G
IS
L
LF
K
K
NK
-
VK
H
L
C
GLA
TL
E
R
A
Q
DEIW
Q
L
R
V
N
-
D
QH-
--
-
I
H
A
R
N
V
VIA
T
GS
Q
P
R
--
QLP
G
V
TID
N
QQ
I
L
D
N
R
G
AL
A
L
SE
VP
P
RL
G
V
I
GAGVIGLE
L
GSV
W
NR
V
GS
D
V
T
L
L
EM
A
P
TF
LPAL
E
AR
L
S
NE
V
RKA
M
I
A
SG
MK
M
Q
L
A
V
E
I
EA
I
E
QR
D
---
DGV
H
V
R
W
RQ
G
E
K
--
R
E
ES
R
F
--
D
K
L
IL
AIGRVP
RL
SG
V
DL
VQL
G
L
E
A
D
N
RG
G
I
A
VD
NLC
RT
G
K
A
G
LW
AIGDVV
R
G
PMLAHKA
MA
EG
V
V
V
A
D
Q
I
--
AG
LA-
-V
E
P
I
NF
AL
IPS
V
IYT
Q
PEVAWVG
E
N
E
AS
L
KA
A
G
R
V
FN
K
G
N
SL
FA
GN
GRA
L
A
L
G
QEG
G
RC
T
L
Y
S
DK
HT
D
RV
L
GGAIVG
PQ
A
S
ELI
N
EI
A
LA
MT
F
---
S
A
S
G
EDIA
C
A
IHAHPTL
S
E
VIH
E
AA
fig|364106.8.peg.4510
Escherichia coli UTI89 (7-462/472)
V
A
V
M
G
G
GP
G
GY
V
AA
L
R
A
A
QN
GL
S
VV
C
I
DDG
VNA
QGE
P
S
P
GG
T
CLNVGCIPSK
S
LL
Q
SS
EL
Y
A
Q
VQHE
A
S
I
HG
VNVEG
V
SF
N
A
A
A
M
I
QR
KD
A
IVSR
L
-
T
M
G
IS
L
LF
K
K
NK
-
VK
H
L
C
GLA
TL
E
R
A
Q
DEIW
Q
L
R
V
N
-
D
QH-
--
-
I
H
A
R
N
V
VIA
T
GS
Q
P
R
--
QLP
G
V
TID
N
QQ
I
L
D
N
R
G
AL
A
L
SE
VP
P
RL
G
V
I
GAGVIGLE
L
GSV
W
NR
V
GS
D
V
T
L
L
EM
A
P
TF
LPAL
E
AR
L
S
NE
V
RKA
M
I
A
SG
MK
M
Q
L
A
V
E
I
EA
I
E
QR
D
---
DGV
H
V
R
W
RQ
G
E
K
--
R
E
ES
R
F
--
D
K
L
IL
AIGRVP
RL
SG
V
DL
VQL
G
L
E
A
D
N
RG
G
I
A
VD
NLC
RT
G
K
A
G
LW
AIGDVV
R
G
PMLAHKA
MA
EG
V
V
V
A
D
Q
I
--
AG
LA-
-V
E
P
I
NF
AL
IPS
V
IYT
Q
PEVAWVG
E
N
E
AS
L
KA
A
G
R
V
FN
K
G
N
SL
FA
GN
GRA
L
A
L
G
QEG
G
RC
T
L
Y
S
DK
HT
D
RV
L
GGAIVG
PQ
A
S
ELI
N
EI
A
LA
MT
F
---
S
A
S
G
EDIA
C
A
IHAHPTL
S
E
VIH
E
AA
fig|431946.3.peg.4078
Escherichia coli SE15 (7-462/472)
V
A
V
M
G
G
GP
G
GY
V
AA
L
R
A
A
QN
GL
S
VV
C
I
DDG
VNA
QGE
P
S
P
GG
T
CLNVGCIPSK
S
LL
Q
SS
EL
Y
A
Q
VQHE
A
S
I
HG
VNVDG
V
SF
N
A
A
A
M
I
QR
KD
A
IVSR
L
-
T
M
G
IS
L
LF
K
K
NK
-
VK
H
L
C
GLA
TL
E
C
A
Q
DEIW
Q
L
R
V
N
-
D
QH-
--
-
L
H
A
R
N
V
VIA
T
GS
Q
P
R
--
QLP
G
V
TID
N
QQ
I
L
D
N
R
G
AL
A
L
SE
VP
P
RL
G
V
I
GAGVIGLE
L
GSV
W
NR
V
GS
D
V
T
L
L
EM
A
P
TF
LPAL
E
AR
L
S
NE
V
RKA
M
I
A
SG
MK
M
Q
L
A
V
E
I
EA
I
E
QR
D
---
DGV
H
V
R
W
RQ
G
E
K
--
R
E
ES
R
F
--
D
K
L
IL
AIGRVP
RL
SG
V
DL
VQL
G
L
E
A
D
N
RG
G
I
A
VD
NLC
RT
G
K
A
G
LW
AIGDVV
R
G
PMLAHKA
MA
EG
V
V
V
A
D
Q
I
--
AG
LV-
-V
E
P
I
NF
AL
IPS
V
IYT
Q
PEVAWVG
E
N
E
AS
L
KA
A
G
R
V
FN
K
G
N
SL
FA
GN
GRA
L
A
L
G
QEG
G
RC
T
L
Y
S
DK
HT
D
RV
L
GGAIVG
PQ
A
S
ELI
N
EI
A
LA
MT
F
---
S
A
S
G
EDIA
C
A
IHAHPTL
S
E
VIH
E
AA
fig|525281.3.peg.1834
Escherichia coli 83972 (7-462/472)
V
A
V
M
G
G
GP
G
GY
V
AA
L
R
A
A
QN
GL
S
VV
C
I
DDG
VNA
QGE
P
S
P
GG
T
CLNVGCIPSK
S
LL
Q
SS
EL
Y
A
Q
VQHE
A
S
I
HG
VNVDG
V
SF
N
A
A
A
M
I
QR
KD
A
IVSR
L
-
T
M
G
IG
L
LF
K
K
NK
-
VK
Y
L
C
GLA
TL
E
H
A
R
DEIW
Q
L
R
V
N
-
D
QQ-
--
-
I
R
A
R
N
V
VIA
T
GS
Q
P
R
--
QLP
G
V
TID
N
QQ
I
L
D
N
R
G
AL
A
L
TA
VP
P
RL
G
V
I
GAGVIGLE
L
GSV
W
NR
V
GS
D
V
T
L
L
EM
A
P
TF
LPAL
E
AR
L
S
NE
V
RKA
M
I
A
SG
MK
M
Q
L
A
V
E
I
EA
I
E
QR
D
---
DGV
H
V
R
W
RQ
G
E
K
--
R
E
ES
R
F
--
D
K
L
IL
AIGRVP
RL
SG
V
DL
VQL
G
L
E
A
D
N
RG
G
I
A
VD
NLC
RT
G
K
A
G
LW
AIGDVV
R
G
PMLAHKA
MA
EG
V
V
V
A
D
Q
I
--
AG
LA-
-V
E
P
I
NF
AL
IPS
V
IYT
Q
PEVAWVG
E
N
E
AS
L
KA
A
G
R
V
FN
K
G
N
SL
FA
GN
GRA
L
A
L
G
QEG
G
RC
T
L
Y
S
DK
HT
D
RV
L
GGAIVG
PQ
A
S
ELI
N
EI
A
LA
MT
F
---
S
A
S
G
EDIA
C
A
IHAHPTL
S
E
VIH
E
AA
fig|655817.3.peg.4780
Escherichia coli ABU 83972 (7-462/472)
V
A
V
M
G
G
GP
G
GY
V
AA
L
R
A
A
QN
GL
S
VV
C
I
DDG
VNA
QGE
P
S
P
GG
T
CLNVGCIPSK
S
LL
Q
SS
EL
Y
A
Q
VQHE
A
S
I
HG
VNVDG
V
SF
N
A
A
A
M
I
QR
KD
A
IVSR
L
-
T
M
G
IG
L
LF
K
K
NK
-
VK
Y
L
C
GLA
TL
E
H
A
R
DEIW
Q
L
R
V
N
-
D
QQ-
--
-
I
R
A
R
N
V
VIA
T
GS
Q
P
R
--
QLP
G
V
TID
N
QQ
I
L
D
N
R
G
AL
A
L
TA
VP
P
RL
G
V
I
GAGVIGLE
L
GSV
W
NR
V
GS
D
V
T
L
L
EM
A
P
TF
LPAL
E
AR
L
S
NE
V
RKA
M
I
A
SG
MK
M
Q
L
A
V
E
I
EA
I
E
QR
D
---
DGV
H
V
R
W
RQ
G
E
K
--
R
E
ES
R
F
--
D
K
L
IL
AIGRVP
RL
SG
V
DL
VQL
G
L
E
A
D
N
RG
G
I
A
VD
NLC
RT
G
K
A
G
LW
AIGDVV
R
G
PMLAHKA
MA
EG
V
V
V
A
D
Q
I
--
AG
LA-
-V
E
P
I
NF
AL
IPS
V
IYT
Q
PEVAWVG
E
N
E
AS
L
KA
A
G
R
V
FN
K
G
N
SL
FA
GN
GRA
L
A
L
G
QEG
G
RC
T
L
Y
S
DK
HT
D
RV
L
GGAIVG
PQ
A
S
ELI
N
EI
A
LA
MT
F
---
S
A
S
G
EDIA
C
A
IHAHPTL
S
E
VIH
E
AA
fig|199310.1.peg.4930
Escherichia coli CFT073 (7-462/472)
V
A
V
M
G
G
GP
G
GY
V
AA
L
R
A
A
QN
GL
S
VV
C
I
DDG
VNA
QGE
P
S
P
GG
T
CLNVGCIPSK
S
LL
Q
SS
EL
Y
A
Q
VQHE
A
S
I
HG
VNVDG
V
SF
N
A
A
A
M
I
QR
KD
A
IVSR
L
-
T
M
G
IG
L
LF
K
K
NK
-
VK
Y
L
C
GLA
TL
E
H
A
R
DEIW
Q
L
R
V
N
-
D
QQ-
--
-
I
R
A
R
N
V
VIA
T
GS
Q
P
R
--
QLP
G
V
TID
N
QQ
I
L
D
N
R
G
AL
A
L
TA
VP
P
RL
G
V
I
GAGVIGLE
L
GSV
W
NR
V
GS
D
V
T
L
L
EM
A
P
TF
LPAL
E
AR
L
S
NE
V
RKA
M
I
A
SG
MK
M
Q
L
A
V
E
I
EA
I
E
QR
D
---
DGV
H
V
R
W
RQ
G
E
K
--
R
E
ES
R
F
--
D
K
L
IL
AIGRVP
RL
SG
V
DL
VQL
G
L
E
A
D
N
RG
G
I
A
VD
NLC
RT
G
K
A
G
LW
AIGDVV
R
G
PMLAHKA
MA
EG
V
V
V
A
D
Q
I
--
AG
LA-
-V
E
P
I
NF
AL
IPS
V
IYT
Q
PEVAWVG
E
N
E
AS
L
KA
A
G
R
V
FN
K
G
N
SL
FA
GN
GRA
L
A
L
G
QEG
G
RC
T
L
Y
S
DK
HT
D
RV
L
GGAIVG
PQ
A
S
ELI
N
EI
A
LA
MT
F
---
S
A
S
G
EDIA
C
A
IHAHPTL
S
E
VIH
E
AA
fig|199310.4.peg.4726
Escherichia coli CFT073 (7-462/472)
V
A
V
M
G
G
GP
G
GY
V
AA
L
R
A
A
QN
GL
S
VV
C
I
DDG
VNA
QGE
P
S
P
GG
T
CLNVGCIPSK
S
LL
Q
SS
EL
Y
A
Q
VQHE
A
S
I
HG
VNVDG
V
SF
N
A
A
A
M
I
QR
KD
A
IVSR
L
-
T
M
G
IG
L
LF
K
K
NK
-
VK
Y
L
C
GLA
TL
E
H
A
R
DEIW
Q
L
R
V
N
-
D
QQ-
--
-
I
R
A
R
N
V
VIA
T
GS
Q
P
R
--
QLP
G
V
TID
N
QQ
I
L
D
N
R
G
AL
A
L
TA
VP
P
RL
G
V
I
GAGVIGLE
L
GSV
W
NR
V
GS
D
V
T
L
L
EM
A
P
TF
LPAL
E
AR
L
S
NE
V
RKA
M
I
A
SG
MK
M
Q
L
A
V
E
I
EA
I
E
QR
D
---
DGV
H
V
R
W
RQ
G
E
K
--
R
E
ES
R
F
--
D
K
L
IL
AIGRVP
RL
SG
V
DL
VQL
G
L
E
A
D
N
RG
G
I
A
VD
NLC
RT
G
K
A
G
LW
AIGDVV
R
G
PMLAHKA
MA
EG
V
V
V
A
D
Q
I
--
AG
LA-
-V
E
P
I
NF
AL
IPS
V
IYT
Q
PEVAWVG
E
N
E
AS
L
KA
A
G
R
V
FN
K
G
N
SL
FA
GN
GRA
L
A
L
G
QEG
G
RC
T
L
Y
S
DK
HT
D
RV
L
GGAIVG
PQ
A
S
ELI
N
EI
A
LA
MT
F
---
S
A
S
G
EDIA
C
A
IHAHPTL
S
E
VIH
E
AA
fig|749546.3.peg.1020
Escherichia coli MS 185-1 (7-462/472)
V
A
V
M
G
G
GP
G
GY
V
AA
L
R
A
A
QN
GL
S
VV
C
I
DDG
VNA
QGE
P
S
P
GG
T
CLNVGCIPSK
S
LL
Q
SS
EL
Y
A
Q
VQHE
A
S
I
HG
VNVDG
V
SF
N
A
A
A
M
I
QR
KD
A
IVSR
L
-
T
M
G
IG
L
LF
K
K
NK
-
VK
Y
L
C
GLA
TL
E
H
A
R
DEIW
Q
L
R
V
N
-
D
QQ-
--
-
I
R
A
R
N
V
VIA
T
GS
Q
P
R
--
QLP
G
V
TID
N
QQ
I
L
D
N
R
G
AL
A
L
TA
VP
P
RL
G
V
I
GAGVIGLE
L
GSV
W
NR
V
GS
D
V
T
L
L
EM
A
P
TF
LPAL
E
AR
L
S
NE
V
RKA
M
I
A
SG
MK
M
Q
L
A
V
E
I
EA
I
E
QR
D
---
DGV
H
V
R
W
RQ
G
E
K
--
R
E
ES
R
F
--
D
K
L
IL
AIGRVP
RL
SG
V
DL
VQL
G
L
E
A
D
N
RG
G
I
A
VD
NLC
RT
G
K
A
G
LW
AIGDVV
R
G
PMLAHKA
MA
EG
V
V
V
A
D
Q
I
--
AG
LA-
-V
E
P
I
NF
AL
IPS
V
IYT
Q
PEVAWVG
E
N
E
AS
L
KA
A
G
R
V
FN
K
G
N
SL
FA
GN
GRA
L
A
L
G
QEG
G
RC
T
L
Y
S
DK
HT
D
RV
L
GGAIVG
PQ
A
S
ELI
N
EI
A
LA
MT
F
---
S
A
S
G
EDIA
C
A
IHAHPTL
S
E
VIH
E
AA
fig|749528.3.peg.4438
Escherichia coli MS 45-1 (7-462/472)
V
A
V
M
G
G
GP
G
GY
V
AA
L
R
A
A
QN
GL
S
VV
C
I
DDG
VNA
QGE
P
S
P
GG
T
CLNVGCIPSK
S
LL
Q
SS
EL
Y
A
Q
VQHE
A
S
I
HG
VNVDG
V
SF
N
A
A
A
M
I
QR
KD
A
IVSR
L
-
T
M
G
IG
L
LF
K
K
NK
-
VK
Y
L
C
GLA
TL
E
H
A
R
DEIW
Q
L
R
V
N
-
D
QQ-
--
-
I
R
A
R
N
V
VIA
T
GS
Q
P
R
--
QLP
G
V
TID
N
QQ
I
L
D
N
R
G
AL
A
L
TA
VP
P
RL
G
V
I
GAGVIGLE
L
GSV
W
NR
V
GS
D
V
T
L
L
EM
A
P
TF
LPAL
E
AR
L
S
NE
V
RKA
M
I
A
SG
MK
M
Q
L
A
V
E
I
EA
I
E
QR
D
---
DGV
H
V
R
W
RQ
G
E
K
--
R
E
ES
R
F
--
D
K
L
IL
AIGRVP
RL
SG
V
DL
VQL
G
L
E
A
D
N
RG
G
I
A
VD
NLC
RT
G
K
A
G
LW
AIGDVV
R
G
PMLAHKA
MA
EG
V
V
V
A
D
Q
I
--
AG
LA-
-V
E
P
I
NF
AL
IPS
V
IYT
Q
PEVAWVG
E
N
E
AS
L
KA
A
G
R
V
FN
K
G
N
SL
FA
GN
GRA
L
A
L
G
QEG
G
RC
T
L
Y
S
DK
HT
D
RV
L
GGAIVG
PQ
A
S
ELI
N
EI
A
LA
MT
F
---
S
A
S
G
EDIA
C
A
IHAHPTL
S
E
VIH
E
AA
fig|753642.3.peg.4106
Escherichia coli NC101 (7-462/472)
V
A
V
M
G
G
GP
G
GY
V
AA
L
R
A
A
QN
GL
S
VV
C
I
DDG
VNA
QGE
P
S
P
GG
T
CLNVGCIPSK
S
LL
Q
SS
EL
Y
A
Q
VQHE
A
S
I
HG
VNVDG
V
SF
N
A
A
A
M
I
QR
KD
A
IVSR
L
-
T
M
G
IG
L
LF
K
K
NK
-
VK
Y
L
C
GLA
TL
E
H
A
R
DEIW
Q
L
R
V
N
-
D
QQ-
--
-
I
R
A
R
N
V
VIA
T
GS
Q
P
R
--
QLP
G
V
TID
N
QQ
I
L
D
N
R
G
AL
A
L
TA
VP
P
RL
G
V
I
GAGVIGLE
L
GSV
W
NR
V
GS
D
V
T
L
L
EM
A
P
TF
LPAL
E
AR
L
S
NE
V
RKA
M
I
A
SG
MK
M
Q
L
A
V
E
I
EA
I
E
QR
D
---
DGV
H
V
R
W
RQ
G
E
K
--
R
E
ES
R
F
--
D
K
L
IL
AIGRVP
RL
SG
V
DL
VQL
G
L
E
A
D
N
RG
G
I
A
VD
NLC
RT
G
K
A
G
LW
AIGDVV
R
G
PMLAHKA
MA
EG
V
V
V
A
D
Q
I
--
AG
LA-
-V
E
P
I
NF
AL
IPS
V
IYT
Q
PEVAWVG
E
N
E
AS
L
KA
A
G
R
V
FN
K
G
N
SL
FA
GN
GRA
L
A
L
G
QEG
G
RC
T
L
Y
S
DK
HT
D
RV
L
GGAIVG
PQ
A
S
ELI
N
EI
A
LA
MT
F
---
S
A
S
G
EDIA
C
A
IHAHPTL
S
E
VIH
E
AA
fig|685038.3.peg.4136
Escherichia coli O83:H1 str. NRG 857C (7-462/472)
V
A
V
M
G
G
GP
G
GY
V
AA
L
R
A
A
QN
GL
S
VV
C
I
DDG
VNA
QGE
P
S
P
GG
T
CLNVGCIPSK
S
LL
Q
SS
EL
Y
A
Q
VQHE
A
S
I
HG
VNVDG
V
SF
N
A
A
A
M
I
QR
KD
A
IVSR
L
-
T
M
G
IG
L
LF
K
K
NK
-
VK
Y
L
C
GLA
TL
E
H
A
R
DEIW
Q
L
R
V
N
-
D
QQ-
--
-
I
R
A
R
N
V
VIA
T
GS
Q
P
R
--
QLP
G
V
TID
N
QQ
I
L
D
N
R
G
AL
A
L
TA
VP
P
RL
G
V
I
GAGVIGLE
L
GSV
W
NR
V
GS
D
V
T
L
L
EM
A
P
TF
LPAL
E
AR
L
S
NE
V
RKA
M
I
A
SG
MK
M
Q
L
A
V
E
I
EA
I
E
QR
D
---
DGV
H
V
R
W
RQ
G
E
K
--
R
E
ES
R
F
--
D
K
L
IL
AIGRVP
RL
SG
V
DL
VQL
G
L
E
A
D
N
RG
G
I
A
VD
NLC
RT
G
K
A
G
LW
AIGDVV
R
G
PMLAHKA
MA
EG
V
V
V
A
D
Q
I
--
AG
LA-
-V
E
P
I
NF
AL
IPS
V
IYT
Q
PEVAWVG
E
N
E
AS
L
KA
A
G
R
V
FN
K
G
N
SL
FA
GN
GRA
L
A
L
G
QEG
G
RC
T
L
Y
S
DK
HT
D
RV
L
GGAIVG
PQ
A
S
ELI
N
EI
A
LA
MT
F
---
S
A
S
G
EDIA
C
A
IHAHPTL
S
E
VIH
E
AA
fig|656440.3.peg.4616
Escherichia coli TA206 (7-462/472)
V
A
V
M
G
G
GP
G
GY
V
AA
L
R
A
A
QN
GL
S
VV
C
I
DDG
VNA
QGE
P
S
P
GG
T
CLNVGCIPSK
S
LL
Q
SS
EL
Y
A
Q
VQHE
A
S
I
HG
VNVDG
V
SF
N
A
A
A
M
I
QR
KD
A
IVSR
L
-
T
M
G
IG
L
LF
K
K
NK
-
VK
Y
L
C
GLA
TL
E
H
A
R
DEIW
Q
L
R
V
N
-
D
QQ-
--
-
I
R
A
R
N
V
VIA
T
GS
Q
P
R
--
QLP
G
V
TID
N
QQ
I
L
D
N
R
G
AL
A
L
TA
VP
P
RL
G
V
I
GAGVIGLE
L
GSV
W
NR
V
GS
D
V
T
L
L
EM
A
P
TF
LPAL
E
AR
L
S
NE
V
RKA
M
I
A
SG
MK
M
Q
L
A
V
E
I
EA
I
E
QR
D
---
DGV
H
V
R
W
RQ
G
E
K
--
R
E
ES
R
F
--
D
K
L
IL
AIGRVP
RL
SG
V
DL
VQL
G
L
E
A
D
N
RG
G
I
A
VD
NLC
RT
G
K
A
G
LW
AIGDVV
R
G
PMLAHKA
MA
EG
V
V
V
A
D
Q
I
--
AG
LA-
-V
E
P
I
NF
AL
IPS
V
IYT
Q
PEVAWVG
E
N
E
AS
L
KA
A
G
R
V
FN
K
G
N
SL
FA
GN
GRA
L
A
L
G
QEG
G
RC
T
L
Y
S
DK
HT
D
RV
L
GGAIVG
PQ
A
S
ELI
N
EI
A
LA
MT
F
---
S
A
S
G
EDIA
C
A
IHAHPTL
S
E
VIH
E
AA
fig|562.376.peg.1702
Escherichia coli WV_060327 (7-462/472)
V
A
V
M
G
G
GP
G
GY
V
AA
L
R
A
A
QN
GL
S
VV
C
I
DDG
VNA
QGE
P
S
P
GG
T
CLNVGCIPSK
S
LL
Q
SS
EL
Y
A
Q
VQHE
A
S
I
HG
VNVDG
V
SF
N
A
A
A
M
I
QR
KD
A
IVSR
L
-
T
M
G
IG
L
LF
K
K
NK
-
VK
Y
L
C
GLA
TL
E
H
A
R
DEIW
Q
L
R
V
N
-
D
QQ-
--
-
I
R
A
R
N
V
VIA
T
GS
Q
P
R
--
QLP
G
V
TID
N
QQ
I
L
D
N
R
G
AL
A
L
TA
VP
P
RL
G
V
I
GAGVIGLE
L
GSV
W
NR
V
GS
D
V
T
L
L
EM
A
P
TF
LPAL
E
AR
L
S
NE
V
RKA
M
I
A
SG
MK
M
Q
L
A
V
E
I
EA
I
E
QR
D
---
DGV
H
V
R
W
RQ
G
E
K
--
R
E
ES
R
F
--
D
K
L
IL
AIGRVP
RL
SG
V
DL
VQL
G
L
E
A
D
N
RG
G
I
A
VD
NLC
RT
G
K
A
G
LW
AIGDVV
R
G
PMLAHKA
MA
EG
V
V
V
A
D
Q
I
--
AG
LA-
-V
E
P
I
NF
AL
IPS
V
IYT
Q
PEVAWVG
E
N
E
AS
L
KA
A
G
R
V
FN
K
G
N
SL
FA
GN
GRA
L
A
L
G
QEG
G
RC
T
L
Y
S
DK
HT
D
RV
L
GGAIVG
PQ
A
S
ELI
N
EI
A
LA
MT
F
---
S
A
S
G
EDIA
C
A
IHAHPTL
S
E
VIH
E
AA
fig|656417.3.peg.5122
Escherichia coli M605 (7-462/472)
V
A
V
M
G
G
GP
G
GY
V
AA
L
R
A
A
QN
GL
S
VV
C
I
DDG
VNA
QGE
P
S
P
GG
T
CLNVGCIPSK
S
LL
Q
SS
EL
Y
A
Q
VQHE
A
S
I
HG
VNVDG
V
SF
N
A
A
A
M
I
QR
KD
A
IVSR
L
-
T
M
G
IG
L
LF
K
K
NK
-
VK
H
L
C
GLA
TL
E
H
A
Q
DEIW
Q
L
R
V
N
-
D
QQ-
--
-
I
R
A
R
N
V
VIA
T
GS
Q
P
R
--
QLP
G
V
TID
N
QQ
I
L
D
N
R
G
AL
A
L
SE
VP
P
RL
G
V
I
GAGVIGLE
L
GSV
W
NR
V
GS
D
V
T
L
L
EM
A
P
TF
LPAL
E
AR
L
S
NE
V
RKA
M
I
A
SG
MK
M
Q
L
A
V
E
I
EA
I
E
QR
D
---
DGV
H
V
R
W
RQ
G
E
K
--
R
E
ES
R
F
--
D
K
L
IL
AIGRVP
RL
SG
V
DL
VQL
G
L
E
A
D
N
RG
G
I
A
VD
NLC
RT
G
K
A
G
LW
AIGDVV
R
G
PMLAHKA
MA
EG
V
V
V
A
D
Q
I
--
AG
LA-
-V
E
P
I
NF
AL
IPS
V
IY
I
Q
PEVAWVG
E
N
E
AS
L
KA
A
G
R
V
FN
K
G
N
SL
FA
GN
GRA
L
A
L
G
QEG
G
RC
T
L
Y
S
DK
HT
D
RV
L
GGAIVG
PQ
A
S
ELI
N
EI
A
LA
MT
F
---
S
A
S
G
EDIA
C
A
IHAHPTL
S
E
VIH
E
AA
fig|362663.8.peg.4309
Escherichia coli 536 (7-462/472)
V
A
V
M
G
G
GP
G
GY
V
AA
L
R
A
A
QN
GL
S
VV
C
I
DDG
VNA
QGE
P
S
P
GG
T
CLNVGCIPSK
S
LL
Q
SS
EL
Y
A
Q
VQHE
A
S
I
HG
VNVDG
V
SF
N
A
A
A
M
I
QR
KD
A
IVSR
L
-
T
M
G
IG
L
LF
K
K
NK
-
VK
H
L
C
GLA
TL
E
H
A
Q
DEIW
Q
L
R
V
N
-
D
QQ-
--
-
I
R
A
R
N
V
VIA
T
GS
Q
P
R
--
QLP
G
V
TID
N
QQ
I
L
D
N
R
G
AL
A
L
TA
VP
P
RL
G
V
I
GAGVIGLE
L
GSV
W
NR
V
GS
D
V
T
L
L
EM
A
P
TF
LPAL
E
AR
L
S
NE
V
RKA
M
I
A
SG
MK
M
Q
L
A
V
E
I
EA
I
E
QR
D
---
DGV
H
V
R
W
RQ
G
E
K
--
R
E
ES
R
F
--
D
K
L
IL
AIGRVP
RL
SG
V
DL
VQL
G
L
E
A
D
N
RG
G
I
A
VD
NLC
RT
G
K
A
G
LW
AIGDVV
R
G
PMLAHKA
MA
EG
V
V
V
A
D
Q
I
--
AG
LA-
-V
E
P
I
NF
AL
IPS
V
IYT
Q
PEVAWVG
E
N
E
AS
L
KA
A
G
R
V
FN
K
G
N
SL
FA
GN
GRA
L
A
L
G
QEG
G
RC
T
L
Y
S
DK
HT
D
RV
L
GGAIVG
PQ
A
S
ELI
N
EI
A
LA
MT
F
---
S
A
S
G
EDIA
C
A
IHAHPTL
S
E
VIH
E
AA
fig|362663.9.peg.4325
Escherichia coli 536 (7-462/472)
V
A
V
M
G
G
GP
G
GY
V
AA
L
R
A
A
QN
GL
S
VV
C
I
DDG
VNA
QGE
P
S
P
GG
T
CLNVGCIPSK
S
LL
Q
SS
EL
Y
A
Q
VQHE
A
S
I
HG
VNVDG
V
SF
N
A
A
A
M
I
QR
KD
A
IVSR
L
-
T
M
G
IG
L
LF
K
K
NK
-
VK
H
L
C
GLA
TL
E
H
A
Q
DEIW
Q
L
R
V
N
-
D
QQ-
--
-
I
R
A
R
N
V
VIA
T
GS
Q
P
R
--
QLP
G
V
TID
N
QQ
I
L
D
N
R
G
AL
A
L
TA
VP
P
RL
G
V
I
GAGVIGLE
L
GSV
W
NR
V
GS
D
V
T
L
L
EM
A
P
TF
LPAL
E
AR
L
S
NE
V
RKA
M
I
A
SG
MK
M
Q
L
A
V
E
I
EA
I
E
QR
D
---
DGV
H
V
R
W
RQ
G
E
K
--
R
E
ES
R
F
--
D
K
L
IL
AIGRVP
RL
SG
V
DL
VQL
G
L
E
A
D
N
RG
G
I
A
VD
NLC
RT
G
K
A
G
LW
AIGDVV
R
G
PMLAHKA
MA
EG
V
V
V
A
D
Q
I
--
AG
LA-
-V
E
P
I
NF
AL
IPS
V
IYT
Q
PEVAWVG
E
N
E
AS
L
KA
A
G
R
V
FN
K
G
N
SL
FA
GN
GRA
L
A
L
G
QEG
G
RC
T
L
Y
S
DK
HT
D
RV
L
GGAIVG
PQ
A
S
ELI
N
EI
A
LA
MT
F
---
S
A
S
G
EDIA
C
A
IHAHPTL
S
E
VIH
E
AA
fig|340197.3.peg.2060
Escherichia coli F11 (7-462/472)
V
A
V
M
G
G
GP
G
GY
V
AA
L
R
A
A
QN
GL
S
VV
C
I
DDG
VNA
QGE
P
S
P
GG
T
CLNVGCIPSK
S
LL
Q
SS
EL
Y
A
Q
VQHE
A
S
I
HG
VNVDG
V
SF
N
A
A
A
M
I
QR
KD
A
IVSR
L
-
T
M
G
IG
L
LF
K
K
NK
-
VK
H
L
C
GLA
TL
E
H
A
Q
DEIW
Q
L
R
V
N
-
D
QQ-
--
-
I
R
A
R
N
V
VIA
T
GS
Q
P
R
--
QLP
G
V
TID
N
QQ
I
L
D
N
R
G
AL
A
L
TA
VP
P
RL
G
V
I
GAGVIGLE
L
GSV
W
NR
V
GS
D
V
T
L
L
EM
A
P
TF
LPAL
E
AR
L
S
NE
V
RKA
M
I
A
SG
MK
M
Q
L
A
V
E
I
EA
I
E
QR
D
---
DGV
H
V
R
W
RQ
G
E
K
--
R
E
ES
R
F
--
D
K
L
IL
AIGRVP
RL
SG
V
DL
VQL
G
L
E
A
D
N
RG
G
I
A
VD
NLC
RT
G
K
A
G
LW
AIGDVV
R
G
PMLAHKA
MA
EG
V
V
V
A
D
Q
I
--
AG
LA-
-V
E
P
I
NF
AL
IPS
V
IYT
Q
PEVAWVG
E
N
E
AS
L
KA
A
G
R
V
FN
K
G
N
SL
FA
GN
GRA
L
A
L
G
QEG
G
RC
T
L
Y
S
DK
HT
D
RV
L
GGAIVG
PQ
A
S
ELI
N
EI
A
LA
MT
F
---
S
A
S
G
EDIA
C
A
IHAHPTL
S
E
VIH
E
AA
fig|340197.5.peg.2172
Escherichia coli F11 (7-462/472)
V
A
V
M
G
G
GP
G
GY
V
AA
L
R
A
A
QN
GL
S
VV
C
I
DDG
VNA
QGE
P
S
P
GG
T
CLNVGCIPSK
S
LL
Q
SS
EL
Y
A
Q
VQHE
A
S
I
HG
VNVDG
V
SF
N
A
A
A
M
I
QR
KD
A
IVSR
L
-
T
M
G
IG
L
LF
K
K
NK
-
VK
H
L
C
GLA
TL
E
H
A
Q
DEIW
Q
L
R
V
N
-
D
QQ-
--
-
I
R
A
R
N
V
VIA
T
GS
Q
P
R
--
QLP
G
V
TID
N
QQ
I
L
D
N
R
G
AL
A
L
TA
VP
P
RL
G
V
I
GAGVIGLE
L
GSV
W
NR
V
GS
D
V
T
L
L
EM
A
P
TF
LPAL
E
AR
L
S
NE
V
RKA
M
I
A
SG
MK
M
Q
L
A
V
E
I
EA
I
E
QR
D
---
DGV
H
V
R
W
RQ
G
E
K
--
R
E
ES
R
F
--
D
K
L
IL
AIGRVP
RL
SG
V
DL
VQL
G
L
E
A
D
N
RG
G
I
A
VD
NLC
RT
G
K
A
G
LW
AIGDVV
R
G
PMLAHKA
MA
EG
V
V
V
A
D
Q
I
--
AG
LA-
-V
E
P
I
NF
AL
IPS
V
IYT
Q
PEVAWVG
E
N
E
AS
L
KA
A
G
R
V
FN
K
G
N
SL
FA
GN
GRA
L
A
L
G
QEG
G
RC
T
L
Y
S
DK
HT
D
RV
L
GGAIVG
PQ
A
S
ELI
N
EI
A
LA
MT
F
---
S
A
S
G
EDIA
C
A
IHAHPTL
S
E
VIH
E
AA
fig|749550.3.peg.1454
Escherichia coli MS 200-1 (7-462/472)
V
A
V
M
G
G
GP
G
GY
V
AA
L
R
A
A
QN
GL
S
VV
C
I
DDG
VNA
QGE
P
S
P
GG
T
CLNVGCIPSK
S
LL
Q
SS
EL
Y
A
Q
VQHE
A
S
I
HG
VNVDG
V
SF
N
A
A
A
M
I
QR
KD
A
IVSR
L
-
T
M
G
IG
L
LF
K
K
NK
-
VK
H
L
C
GLA
TL
E
H
A
Q
DEIW
Q
L
R
V
N
-
D
QQ-
--
-
I
R
A
R
N
V
VIA
T
GS
Q
P
R
--
QLP
G
V
TID
N
QQ
I
L
D
N
R
G
AL
A
L
TA
VP
P
RL
G
V
I
GAGVIGLE
L
GSV
W
NR
V
GS
D
V
T
L
L
EM
A
P
TF
LPAL
E
AR
L
S
NE
V
RKA
M
I
A
SG
MK
M
Q
L
A
V
E
I
EA
I
E
QR
D
---
DGV
H
V
R
W
RQ
G
E
K
--
R
E
ES
R
F
--
D
K
L
IL
AIGRVP
RL
SG
V
DL
VQL
G
L
E
A
D
N
RG
G
I
A
VD
NLC
RT
G
K
A
G
LW
AIGDVV
R
G
PMLAHKA
MA
EG
V
V
V
A
D
Q
I
--
AG
LA-
-V
E
P
I
NF
AL
IPS
V
IYT
Q
PEVAWVG
E
N
E
AS
L
KA
A
G
R
V
FN
K
G
N
SL
FA
GN
GRA
L
A
L
G
QEG
G
RC
T
L
Y
S
DK
HT
D
RV
L
GGAIVG
PQ
A
S
ELI
N
EI
A
LA
MT
F
---
S
A
S
G
EDIA
C
A
IHAHPTL
S
E
VIH
E
AA
fig|670897.3.peg.1353
Escherichia coli 2362-75 (7-462/472)
V
A
V
M
G
G
GP
G
GY
V
AA
L
R
A
A
QN
GL
S
VV
C
I
DDG
VNA
QGE
P
S
P
GG
T
CLNVGCIPSK
S
LL
Q
SS
EL
Y
A
Q
VQHE
A
S
I
HG
VNVDG
V
SF
N
A
A
A
M
I
QR
KD
A
IVSR
L
-
T
M
G
IG
L
LF
K
K
NK
-
VK
H
L
C
GLA
TL
E
H
A
Q
DEIW
Q
L
R
V
N
-
D
QQ-
--
-
I
R
A
R
N
V
VIA
T
GS
Q
P
R
--
QLP
G
V
TID
N
QQ
I
L
D
N
R
G
AL
A
L
TA
VP
P
RL
G
V
I
GAGVIGLE
L
GSV
W
NR
V
GS
D
V
T
L
L
EM
A
P
TF
LPAL
E
AR
L
S
NE
V
RKA
M
I
A
SG
MK
M
Q
L
A
V
E
I
EA
I
E
QR
D
---
DGV
H
V
R
W
RQ
G
E
K
--
R
E
ES
R
F
--
D
K
L
IL
AIGRVP
RL
SG
V
DL
VQL
G
L
E
A
D
N
RG
G
I
A
VD
NLC
RT
G
K
A
G
LW
AIGDVV
R
G
PMLAHKA
MA
EG
V
V
V
A
D
Q
I
--
AG
LA-
-V
E
P
I
NF
AL
IPS
V
IYT
Q
PEVAWVG
E
N
E
AS
L
KA
A
G
R
V
FN
K
G
N
SL
FA
GN
GRA
L
A
L
G
QEG
G
RC
T
L
Y
S
DK
HT
D
RV
L
GGAIVG
PQ
A
S
ELI
N
EI
A
LA
MT
F
---
S
A
S
G
EDI
V
C
A
IHAHPTL
S
E
VIH
E
AA
fig|216593.1.peg.3967
Escherichia coli E2348/69 (7-462/472)
V
A
V
M
G
G
GP
G
GY
V
AA
L
R
A
A
QN
GL
S
VV
C
I
DDG
VNA
QGE
P
S
P
GG
T
CLNVGCIPSK
S
LL
Q
SS
EL
Y
A
Q
VQHE
A
S
I
HG
VNVDG
V
SF
N
A
A
A
M
I
QR
KD
A
IVSR
L
-
T
M
G
IG
L
LF
K
K
NK
-
VK
H
L
C
GLA
TL
E
H
A
Q
DEIW
Q
L
R
V
N
-
D
QQ-
--
-
I
R
A
R
N
V
VIA
T
GS
Q
P
R
--
QLP
G
V
TID
N
QQ
I
L
D
N
R
G
AL
A
L
TA
VP
P
RL
G
V
I
GAGVIGLE
L
GSV
W
NR
V
GS
D
V
T
L
L
EM
A
P
TF
LPAL
E
AR
L
S
NE
V
RKA
M
I
A
SG
MK
M
Q
L
A
V
E
I
EA
I
E
QR
D
---
DGV
H
V
R
W
RQ
G
E
K
--
R
E
ES
R
F
--
D
K
L
IL
AIGRVP
RL
SG
V
DL
VQL
G
L
E
A
D
N
RG
G
I
A
VD
NLC
RT
G
K
A
G
LW
AIGDVV
R
G
PMLAHKA
MA
EG
V
V
V
A
D
Q
I
--
AG
LA-
-V
E
P
I
NF
AL
IPS
V
IYT
Q
PEVAWVG
E
N
E
AS
L
KA
A
G
R
V
FN
K
G
N
SL
FA
GN
GRA
L
A
L
G
QEG
G
RC
T
L
Y
S
DK
HT
D
RV
L
GGAIVG
PQ
A
S
ELI
N
EI
A
LA
MT
F
---
S
A
S
G
EDI
V
C
A
IHAHPTL
S
E
VIH
E
AA
fig|574521.7.peg.4471
Escherichia coli O127:H6 str. E2348/69 (7-462/472)
V
A
V
M
G
G
GP
G
GY
V
AA
L
R
A
A
QN
GL
S
VV
C
I
DDG
VNA
QGE
P
S
P
GG
T
CLNVGCIPSK
S
LL
Q
SS
EL
Y
A
Q
VQHE
A
S
I
HG
VNVDG
V
SF
N
A
A
A
M
I
QR
KD
A
IVSR
L
-
T
M
G
IG
L
LF
K
K
NK
-
VK
H
L
C
GLA
TL
E
H
A
Q
DEIW
Q
L
R
V
N
-
D
QQ-
--
-
I
R
A
R
N
V
VIA
T
GS
Q
P
R
--
QLP
G
V
TID
N
QQ
I
L
D
N
R
G
AL
A
L
TA
VP
P
RL
G
V
I
GAGVIGLE
L
GSV
W
NR
V
GS
D
V
T
L
L
EM
A
P
TF
LPAL
E
AR
L
S
NE
V
RKA
M
I
A
SG
MK
M
Q
L
A
V
E
I
EA
I
E
QR
D
---
DGV
H
V
R
W
RQ
G
E
K
--
R
E
ES
R
F
--
D
K
L
IL
AIGRVP
RL
SG
V
DL
VQL
G
L
E
A
D
N
RG
G
I
A
VD
NLC
RT
G
K
A
G
LW
AIGDVV
R
G
PMLAHKA
MA
EG
V
V
V
A
D
Q
I
--
AG
LA-
-V
E
P
I
NF
AL
IPS
V
IYT
Q
PEVAWVG
E
N
E
AS
L
KA
A
G
R
V
FN
K
G
N
SL
FA
GN
GRA
L
A
L
G
QEG
G
RC
T
L
Y
S
DK
HT
D
RV
L
GGAIVG
PQ
A
S
ELI
N
EI
A
LA
MT
F
---
S
A
S
G
EDI
V
C
A
IHAHPTL
S
E
VIH
E
AA
fig|749545.3.peg.4864
Escherichia coli MS 182-1 (100-556/561)
QV
A
VIGSG
G
A
AM
A
AA
L
K
A
V
E
QG
A
Q
V
T
L
I
ER
G
---
---
-
T
I
GG
T
C
V
NVGC
V
PSK
I
MI
R
AA
HI
A
H
L
RRES
P
F
DG
G
MPPTP
P
TI
L
R
E
R
L
L
AQ
Q
Q
A
R
V
E
E
L
RH
A
K
YE
G
IL
D
GN
SA
I
T
VL
H
G
E
ARF
K
D
D
Q
----
S
L
I
V
SL
N
E
GG
ER
V
V
M
FD
R
C
LV
A
T
G
A
S
P
A
MPP
I
P
G
L
--K
E
SPY
W
T
ST
E
AL
V
S
DT
I
PERL
A
V
I
G
S
S
V
V
A
LE
L
A
QA
F
AR
LGS
Q
V
T
IL
AR
N
T
LF
F-RD
D
PS
I
G
EA
V
TAA
F
R
A
E
G
IK
V
L
E
H
T
Q
A
SQ
V
A
HV
N
---
-
G
E
F
V
L
-
--
---
-
T
T
G
HG
E
V
R
A
D
K
LLVA
T
GR
T
PNT
RS
L
A
L
DAA
GV
T
V
N
A
Q
G
A
I
V
I
D
KGM
RT
S
T
PHIYA
A
GD
CTD
QP
QFV
Y
V
A
AA
A
G
T
R
AA
I
N
M
--
T
GG
D
A
AI
N
L
---
TA
M
P
A
V
VF
T
D
P
Q
VA
T
VG
Y
S
E
AE
A
HH
D
GI
E
T
D
S
R
T
LT
LD
NV
P
RA
L
A
N
F
DTR
G
FI
KL
V
I
EE
G
S
G
R
L
IG
VQ
V
V
A
PE
AGELI
Q
TA
V
LAI
R
N
---
R
M
T
V
QEL
A
D
Q
L
F
P
Y
L
T
M
V
E
GLK
LAA
QT
F
T
KDVKQ
L
fig|585397.7.peg.4662
Escherichia coli ED1a (10-458/466)
I
VIGSGP
G
G
E
G
AA
M
G
L
V
K
QG
A
RV
A
V
I
------
ERY
Q
N
V
GG
G
C
THW
G
T
IPSKAL
R
HA
V
SR
I
I
E
FNQN
P
L
-
YS
DHSRL
L
RS
S
F
A
D
IL
NH
A
D
N
VINQ
Q
-
T
R
M
RQ
G
FY
ER
N
H
-
CEI
L
Q
G
N
ARF
V
D
E
H
----
TL
A
L
D
C
P
DG
S
VE
TL
T
AEK
F
VIA
C
GSRP
Y
--
HPT
D
V
DFT
H
PRI
Y
DS
N
S
I
L
S
M
HH
E
P
R
HV
L
I
Y
GAGVIG
C
E
Y
A
S
I
F
RG
MDV
KVDL
I
NT
R
D
RL
L
AF
LD
QE
M
S
DS
L
SYH
F
W
N
SG
VV
I
R
H
N
E
E
Y
E
KI
E
GC
D
---
DGV
I
M
H
L
KS
GKK
--
-
-
--
-
L
KA
D
C
LL
Y
A
N
GR
TG
NT
DS
L
A
L
QNI
G
L
E
T
D
S
RG
Q
L
K
V
N
SMY
Q
T
A
Q
PH
V
YA
V
GDV
I
G
Y
P
S
LA
SA
A
YD
Q
G
R
I
AA
Q
A
L
--
VK
G
E
A
NA
H
LI
--
ED
IP
T
G
IYT
I
PE
ISS
VG
K
TE
QQ
LT
A
M
KV
P
YE
V
G
R
AQ
F
K
HL
A
RA
Q
I
V
G
MNV
G
TL
K
I
L
F
HR
E
T
K
EIL
G
IHCF
G
ER
A
A
E
I
I
H
IG
Q
AIM
E
Q
KGG
G
N
T
I
E
YFV
N
T
TFNY
PT
M
A
E
AYR
V
AA
fig|585397.9.peg.4660
Escherichia coli ED1a (10-458/466)
I
VIGSGP
G
G
E
G
AA
M
G
L
V
K
QG
A
RV
A
V
I
------
ERY
Q
N
V
GG
G
C
THW
G
T
IPSKAL
R
HA
V
SR
I
I
E
FNQN
P
L
-
YS
DHSRL
L
RS
S
F
A
D
IL
NH
A
D
N
VINQ
Q
-
T
R
M
RQ
G
FY
ER
N
H
-
CEI
L
Q
G
N
ARF
V
D
E
H
----
TL
A
L
D
C
P
DG
S
VE
TL
T
AEK
F
VIA
C
GSRP
Y
--
HPT
D
V
DFT
H
PRI
Y
DS
N
S
I
L
S
M
HH
E
P
R
HV
L
I
Y
GAGVIG
C
E
Y
A
S
I
F
RG
MDV
KVDL
I
NT
R
D
RL
L
AF
LD
QE
M
S
DS
L
SYH
F
W
N
SG
VV
I
R
H
N
E
E
Y
E
KI
E
GC
D
---
DGV
I
M
H
L
KS
GKK
--
-
-
--
-
L
KA
D
C
LL
Y
A
N
GR
TG
NT
DS
L
A
L
QNI
G
L
E
T
D
S
RG
Q
L
K
V
N
SMY
Q
T
A
Q
PH
V
YA
V
GDV
I
G
Y
P
S
LA
SA
A
YD
Q
G
R
I
AA
Q
A
L
--
VK
G
E
A
NA
H
LI
--
ED
IP
T
G
IYT
I
PE
ISS
VG
K
TE
QQ
LT
A
M
KV
P
YE
V
G
R
AQ
F
K
HL
A
RA
Q
I
V
G
MNV
G
TL
K
I
L
F
HR
E
T
K
EIL
G
IHCF
G
ER
A
A
E
I
I
H
IG
Q
AIM
E
Q
KGG
G
N
T
I
E
YFV
N
T
TFNY
PT
M
A
E
AYR
V
AA
fig|340186.3.peg.1271
Escherichia coli E110019 (10-458/466)
I
VIGSGP
G
G
E
G
AA
M
G
L
V
K
QG
A
RV
A
V
I
------
ERY
Q
N
V
GG
G
C
THW
G
T
IPSKAL
R
HA
V
SR
I
I
E
FNQN
P
L
-
YS
DHSRL
L
RS
S
F
A
D
IL
NH
A
D
N
VINQ
Q
-
T
R
M
RQ
G
FY
ER
N
H
-
CEI
L
Q
G
N
ARF
V
D
E
H
----
TL
A
L
D
C
P
DG
S
VE
TL
T
AEK
F
VIA
C
GSRP
Y
--
HPT
D
V
DFT
H
PRI
Y
DS
D
S
I
L
S
M
HH
E
P
R
HV
L
I
Y
GAGVIG
C
E
Y
A
S
I
F
RG
MDV
KVDL
I
NT
R
D
RL
L
AF
LD
QE
M
S
DS
L
SYH
F
W
N
SG
VV
I
R
H
N
E
E
Y
E
KI
E
GC
D
---
DGV
I
M
H
L
KS
GKK
--
-
-
--
-
L
KA
D
C
LL
Y
A
N
GR
TG
NT
DS
L
A
L
QNI
G
L
E
T
D
S
RG
Q
L
K
V
N
SMY
Q
T
A
Q
PH
V
YA
V
GDV
I
G
Y
P
S
LA
SA
A
YD
Q
G
R
I
AA
Q
A
L
--
VK
G
E
A
TA
H
LI
--
ED
IP
T
G
IYT
I
PE
ISS
VG
K
TE
QQ
LT
A
M
KV
P
YE
V
G
R
AQ
F
K
HL
A
RA
Q
I
V
G
MNV
G
TL
K
I
L
F
HR
E
T
K
EIL
G
IHCF
G
ER
A
A
E
I
I
H
IG
Q
AIM
E
Q
K
D
G
G
N
T
I
E
YFV
N
T
TFNY
PT
M
A
E
AYR
V
AA
fig|340186.5.peg.1318
Escherichia coli E110019 (10-458/466)
I
VIGSGP
G
G
E
G
AA
M
G
L
V
K
QG
A
RV
A
V
I
------
ERY
Q
N
V
GG
G
C
THW
G
T
IPSKAL
R
HA
V
SR
I
I
E
FNQN
P
L
-
YS
DHSRL
L
RS
S
F
A
D
IL
NH
A
D
N
VINQ
Q
-
T
R
M
RQ
G
FY
ER
N
H
-
CEI
L
Q
G
N
ARF
V
D
E
H
----
TL
A
L
D
C
P
DG
S
VE
TL
T
AEK
F
VIA
C
GSRP
Y
--
HPT
D
V
DFT
H
PRI
Y
DS
D
S
I
L
S
M
HH
E
P
R
HV
L
I
Y
GAGVIG
C
E
Y
A
S
I
F
RG
MDV
KVDL
I
NT
R
D
RL
L
AF
LD
QE
M
S
DS
L
SYH
F
W
N
SG
VV
I
R
H
N
E
E
Y
E
KI
E
GC
D
---
DGV
I
M
H
L
KS
GKK
--
-
-
--
-
L
KA
D
C
LL
Y
A
N
GR
TG
NT
DS
L
A
L
QNI
G
L
E
T
D
S
RG
Q
L
K
V
N
SMY
Q
T
A
Q
PH
V
YA
V
GDV
I
G
Y
P
S
LA
SA
A
YD
Q
G
R
I
AA
Q
A
L
--
VK
G
E
A
TA
H
LI
--
ED
IP
T
G
IYT
I
PE
ISS
VG
K
TE
QQ
LT
A
M
KV
P
YE
V
G
R
AQ
F
K
HL
A
RA
Q
I
V
G
MNV
G
TL
K
I
L
F
HR
E
T
K
EIL
G
IHCF
G
ER
A
A
E
I
I
H
IG
Q
AIM
E
Q
K
D
G
G
N
T
I
E
YFV
N
T
TFNY
PT
M
A
E
AYR
V
AA
fig|525281.3.peg.3320
Escherichia coli 83972 (10-458/466)
I
VIGSGP
G
G
E
G
AA
M
G
L
V
K
QG
A
RV
A
V
I
------
ERY
Q
N
V
GG
G
C
THW
G
T
IPSKAL
R
HA
V
SR
I
I
E
FNQN
P
L
-
YS
DHSRL
L
RS
S
F
A
D
IL
NH
A
D
N
VINQ
Q
-
T
R
M
RQ
G
FY
ER
N
H
-
CEI
L
Q
G
N
ARF
V
D
E
H
----
TL
A
L
D
C
P
DG
S
VE
TL
T
AEK
F
VIA
C
GSRP
Y
--
HPT
D
V
DFT
H
PRI
Y
DS
D
S
I
L
S
M
HH
E
P
R
HV
L
I
Y
GAGVIG
C
E
Y
A
S
I
F
RG
MDV
KVDL
I
NT
R
D
RL
L
AF
LD
QE
M
S
DS
L
SYH
F
W
N
SG
VV
I
R
H
N
E
E
Y
E
KI
E
GC
D
---
DGV
I
M
H
L
KS
GKK
--
-
-
--
-
L
KA
D
C
LL
Y
A
N
GR
TG
NT
DS
L
A
L
QNI
G
L
E
T
D
S
RG
Q
L
K
V
N
SMY
Q
T
A
Q
PH
V
YA
V
GDV
I
G
Y
P
S
LA
SA
A
YD
Q
G
R
I
AA
Q
A
L
--
VK
G
E
A
NA
H
LI
--
ED
IP
T
G
IYT
I
PE
ISS
VG
K
TE
QQ
LT
A
M
KV
P
YE
V
G
R
AQ
F
K
HL
A
RA
Q
I
V
G
MNV
G
TL
K
I
L
F
HR
E
T
K
EIL
G
IHCF
G
ER
A
A
E
I
I
H
IG
Q
AIM
E
Q
KGG
G
N
T
I
E
YFV
N
T
TFNY
PT
M
A
E
AYR
V
AA
fig|655817.3.peg.4673
Escherichia coli ABU 83972 (10-458/466)
I
VIGSGP
G
G
E
G
AA
M
G
L
V
K
QG
A
RV
A
V
I
------
ERY
Q
N
V
GG
G
C
THW
G
T
IPSKAL
R
HA
V
SR
I
I
E
FNQN
P
L
-
YS
DHSRL
L
RS
S
F
A
D
IL
NH
A
D
N
VINQ
Q
-
T
R
M
RQ
G
FY
ER
N
H
-
CEI
L
Q
G
N
ARF
V
D
E
H
----
TL
A
L
D
C
P
DG
S
VE
TL
T
AEK
F
VIA
C
GSRP
Y
--
HPT
D
V
DFT
H
PRI
Y
DS
D
S
I
L
S
M
HH
E
P
R
HV
L
I
Y
GAGVIG
C
E
Y
A
S
I
F
RG
MDV
KVDL
I
NT
R
D
RL
L
AF
LD
QE
M
S
DS
L
SYH
F
W
N
SG
VV
I
R
H
N
E
E
Y
E
KI
E
GC
D
---
DGV
I
M
H
L
KS
GKK
--
-
-
--
-
L
KA
D
C
LL
Y
A
N
GR
TG
NT
DS
L
A
L
QNI
G
L
E
T
D
S
RG
Q
L
K
V
N
SMY
Q
T
A
Q
PH
V
YA
V
GDV
I
G
Y
P
S
LA
SA
A
YD
Q
G
R
I
AA
Q
A
L
--
VK
G
E
A
NA
H
LI
--
ED
IP
T
G
IYT
I
PE
ISS
VG
K
TE
QQ
LT
A
M
KV
P
YE
V
G
R
AQ
F
K
HL
A
RA
Q
I
V
G
MNV
G
TL
K
I
L
F
HR
E
T
K
EIL
G
IHCF
G
ER
A
A
E
I
I
H
IG
Q
AIM
E
Q
KGG
G
N
T
I
E
YFV
N
T
TFNY
PT
M
A
E
AYR
V
AA
fig|199310.1.peg.4820
Escherichia coli CFT073 (10-458/466)
I
VIGSGP
G
G
E
G
AA
M
G
L
V
K
QG
A
RV
A
V
I
------
ERY
Q
N
V
GG
G
C
THW
G
T
IPSKAL
R
HA
V
SR
I
I
E
FNQN
P
L
-
YS
DHSRL
L
RS
S
F
A
D
IL
NH
A
D
N
VINQ
Q
-
T
R
M
RQ
G
FY
ER
N
H
-
CEI
L
Q
G
N
ARF
V
D
E
H
----
TL
A
L
D
C
P
DG
S
VE
TL
T
AEK
F
VIA
C
GSRP
Y
--
HPT
D
V
DFT
H
PRI
Y
DS
D
S
I
L
S
M
HH
E
P
R
HV
L
I
Y
GAGVIG
C
E
Y
A
S
I
F
RG
MDV
KVDL
I
NT
R
D
RL
L
AF
LD
QE
M
S
DS
L
SYH
F
W
N
SG
VV
I
R
H
N
E
E
Y
E
KI
E
GC
D
---
DGV
I
M
H
L
KS
GKK
--
-
-
--
-
L
KA
D
C
LL
Y
A
N
GR
TG
NT
DS
L
A
L
QNI
G
L
E
T
D
S
RG
Q
L
K
V
N
SMY
Q
T
A
Q
PH
V
YA
V
GDV
I
G
Y
P
S
LA
SA
A
YD
Q
G
R
I
AA
Q
A
L
--
VK
G
E
A
NA
H
LI
--
ED
IP
T
G
IYT
I
PE
ISS
VG
K
TE
QQ
LT
A
M
KV
P
YE
V
G
R
AQ
F
K
HL
A
RA
Q
I
V
G
MNV
G
TL
K
I
L
F
HR
E
T
K
EIL
G
IHCF
G
ER
A
A
E
I
I
H
IG
Q
AIM
E
Q
KGG
G
N
T
I
E
YFV
N
T
TFNY
PT
M
A
E
AYR
V
AA
fig|199310.4.peg.4623
Escherichia coli CFT073 (10-458/466)
I
VIGSGP
G
G
E
G
AA
M
G
L
V
K
QG
A
RV
A
V
I
------
ERY
Q
N
V
GG
G
C
THW
G
T
IPSKAL
R
HA
V
SR
I
I
E
FNQN
P
L
-
YS
DHSRL
L
RS
S
F
A
D
IL
NH
A
D
N
VINQ
Q
-
T
R
M
RQ
G
FY
ER
N
H
-
CEI
L
Q
G
N
ARF
V
D
E
H
----
TL
A
L
D
C
P
DG
S
VE
TL
T
AEK
F
VIA
C
GSRP
Y
--
HPT
D
V
DFT
H
PRI
Y
DS
D
S
I
L
S
M
HH
E
P
R
HV
L
I
Y
GAGVIG
C
E
Y
A
S
I
F
RG
MDV
KVDL
I
NT
R
D
RL
L
AF
LD
QE
M
S
DS
L
SYH
F
W
N
SG
VV
I
R
H
N
E
E
Y
E
KI
E
GC
D
---
DGV
I
M
H
L
KS
GKK
--
-
-
--
-
L
KA
D
C
LL
Y
A
N
GR
TG
NT
DS
L
A
L
QNI
G
L
E
T
D
S
RG
Q
L
K
V
N
SMY
Q
T
A
Q
PH
V
YA
V
GDV
I
G
Y
P
S
LA
SA
A
YD
Q
G
R
I
AA
Q
A
L
--
VK
G
E
A
NA
H
LI
--
ED
IP
T
G
IYT
I
PE
ISS
VG
K
TE
QQ
LT
A
M
KV
P
YE
V
G
R
AQ
F
K
HL
A
RA
Q
I
V
G
MNV
G
TL
K
I
L
F
HR
E
T
K
EIL
G
IHCF
G
ER
A
A
E
I
I
H
IG
Q
AIM
E
Q
KGG
G
N
T
I
E
YFV
N
T
TFNY
PT
M
A
E
AYR
V
AA
fig|749546.3.peg.2500
Escherichia coli MS 185-1 (10-458/466)
I
VIGSGP
G
G
E
G
AA
M
G
L
V
K
QG
A
RV
A
V
I
------
ERY
Q
N
V
GG
G
C
THW
G
T
IPSKAL
R
HA
V
SR
I
I
E
FNQN
P
L
-
YS
DHSRL
L
RS
S
F
A
D
IL
NH
A
D
N
VINQ
Q
-
T
R
M
RQ
G
FY
ER
N
H
-
CEI
L
Q
G
N
ARF
V
D
E
H
----
TL
A
L
D
C
P
DG
S
VE
TL
T
AEK
F
VIA
C
GSRP
Y
--
HPT
D
V
DFT
H
PRI
Y
DS
D
S
I
L
S
M
HH
E
P
R
HV
L
I
Y
GAGVIG
C
E
Y
A
S
I
F
RG
MDV
KVDL
I
NT
R
D
RL
L
AF
LD
QE
M
S
DS
L
SYH
F
W
N
SG
VV
I
R
H
N
E
E
Y
E
KI
E
GC
D
---
DGV
I
M
H
L
KS
GKK
--
-
-
--
-
L
KA
D
C
LL
Y
A
N
GR
TG
NT
DS
L
A
L
QNI
G
L
E
T
D
S
RG
Q
L
K
V
N
SMY
Q
T
A
Q
PH
V
YA
V
GDV
I
G
Y
P
S
LA
SA
A
YD
Q
G
R
I
AA
Q
A
L
--
VK
G
E
A
NA
H
LI
--
ED
IP
T
G
IYT
I
PE
ISS
VG
K
TE
QQ
LT
A
M
KV
P
YE
V
G
R
AQ
F
K
HL
A
RA
Q
I
V
G
MNV
G
TL
K
I
L
F
HR
E
T
K
EIL
G
IHCF
G
ER
A
A
E
I
I
H
IG
Q
AIM
E
Q
KGG
G
N
T
I
E
YFV
N
T
TFNY
PT
M
A
E
AYR
V
AA
fig|749528.3.peg.1128
Escherichia coli MS 45-1 (10-458/466)
I
VIGSGP
G
G
E
G
AA
M
G
L
V
K
QG
A
RV
A
V
I
------
ERY
Q
N
V
GG
G
C
THW
G
T
IPSKAL
R
HA
V
SR
I
I
E
FNQN
P
L
-
YS
DHSRL
L
RS
S
F
A
D
IL
NH
A
D
N
VINQ
Q
-
T
R
M
RQ
G
FY
ER
N
H
-
CEI
L
Q
G
N
ARF
V
D
E
H
----
TL
A
L
D
C
P
DG
S
VE
TL
T
AEK
F
VIA
C
GSRP
Y
--
HPT
D
V
DFT
H
PRI
Y
DS
D
S
I
L
S
M
HH
E
P
R
HV
L
I
Y
GAGVIG
C
E
Y
A
S
I
F
RG
MDV
KVDL
I
NT
R
D
RL
L
AF
LD
QE
M
S
DS
L
SYH
F
W
N
SG
VV
I
R
H
N
E
E
Y
E
KI
E
GC
D
---
DGV
I
M
H
L
KS
GKK
--
-
-
--
-
L
KA
D
C
LL
Y
A
N
GR
TG
NT
DS
L
A
L
QNI
G
L
E
T
D
S
RG
Q
L
K
V
N
SMY
Q
T
A
Q
PH
V
YA
V
GDV
I
G
Y
P
S
LA
SA
A
YD
Q
G
R
I
AA
Q
A
L
--
VK
G
E
A
NA
H
LI
--
ED
IP
T
G
IYT
I
PE
ISS
VG
K
TE
QQ
LT
A
M
KV
P
YE
V
G
R
AQ
F
K
HL
A
RA
Q
I
V
G
MNV
G
TL
K
I
L
F
HR
E
T
K
EIL
G
IHCF
G
ER
A
A
E
I
I
H
IG
Q
AIM
E
Q
KGG
G
N
T
I
E
YFV
N
T
TFNY
PT
M
A
E
AYR
V
AA
fig|753642.3.peg.1910
Escherichia coli NC101 (10-458/466)
I
VIGSGP
G
G
E
G
AA
M
G
L
V
K
QG
A
RV
A
V
I
------
ERY
Q
N
V
GG
G
C
THW
G
T
IPSKAL
R
HA
V
SR
I
I
E
FNQN
P
L
-
YS
DHSRL
L
RS
S
F
A
D
IL
NH
A
D
N
VINQ
Q
-
T
R
M
RQ
G
FY
ER
N
H
-
CEI
L
Q
G
N
ARF
V
D
E
H
----
TL
A
L
D
C
P
DG
S
VE
TL
T
AEK
F
VIA
C
GSRP
Y
--
HPT
D
V
DFT
H
PRI
Y
DS
D
S
I
L
S
M
HH
E
P
R
HV
L
I
Y
GAGVIG
C
E
Y
A
S
I
F
RG
MDV
KVDL
I
NT
R
D
RL
L
AF
LD
QE
M
S
DS
L
SYH
F
W
N
SG
VV
I
R
H
N
E
E
Y
E
KI
E
GC
D
---
DGV
I
M
H
L
KS
GKK
--
-
-
--
-
L
KA
D
C
LL
Y
A
N
GR
TG
NT
DS
L
A
L
QNI
G
L
E
T
D
S
RG
Q
L
K
V
N
SMY
Q
T
A
Q
PH
V
YA
V
GDV
I
G
Y
P
S
LA
SA
A
YD
Q
G
R
I
AA
Q
A
L
--
VK
G
E
A
NA
H
LI
--
ED
IP
T
G
IYT
I
PE
ISS
VG
K
TE
QQ
LT
A
M
KV
P
YE
V
G
R
AQ
F
K
HL
A
RA
Q
I
V
G
MNV
G
TL
K
I
L
F
HR
E
T
K
EIL
G
IHCF
G
ER
A
A
E
I
I
H
IG
Q
AIM
E
Q
KGG
G
N
T
I
E
YFV
N
T
TFNY
PT
M
A
E
AYR
V
AA
fig|685038.3.peg.4041
Escherichia coli O83:H1 str. NRG 857C (10-458/466)
I
VIGSGP
G
G
E
G
AA
M
G
L
V
K
QG
A
RV
A
V
I
------
ERY
Q
N
V
GG
G
C
THW
G
T
IPSKAL
R
HA
V
SR
I
I
E
FNQN
P
L
-
YS
DHSRL
L
RS
S
F
A
D
IL
NH
A
D
N
VINQ
Q
-
T
R
M
RQ
G
FY
ER
N
H
-
CEI
L
Q
G
N
ARF
V
D
E
H
----
TL
A
L
D
C
P
DG
S
VE
TL
T
AEK
F
VIA
C
GSRP
Y
--
HPT
D
V
DFT
H
PRI
Y
DS
D
S
I
L
S
M
HH
E
P
R
HV
L
I
Y
GAGVIG
C
E
Y
A
S
I
F
RG
MDV
KVDL
I
NT
R
D
RL
L
AF
LD
QE
M
S
DS
L
SYH
F
W
N
SG
VV
I
R
H
N
E
E
Y
E
KI
E
GC
D
---
DGV
I
M
H
L
KS
GKK
--
-
-
--
-
L
KA
D
C
LL
Y
A
N
GR
TG
NT
DS
L
A
L
QNI
G
L
E
T
D
S
RG
Q
L
K
V
N
SMY
Q
T
A
Q
PH
V
YA
V
GDV
I
G
Y
P
S
LA
SA
A
YD
Q
G
R
I
AA
Q
A
L
--
VK
G
E
A
NA
H
LI
--
ED
IP
T
G
IYT
I
PE
ISS
VG
K
TE
QQ
LT
A
M
KV
P
YE
V
G
R
AQ
F
K
HL
A
RA
Q
I
V
G
MNV
G
TL
K
I
L
F
HR
E
T
K
EIL
G
IHCF
G
ER
A
A
E
I
I
H
IG
Q
AIM
E
Q
KGG
G
N
T
I
E
YFV
N
T
TFNY
PT
M
A
E
AYR
V
AA
fig|670888.3.peg.2252
Escherichia coli 1827-70 (10-458/466)
I
VIGSGP
G
G
E
G
AA
M
G
L
V
K
QG
A
RV
A
V
I
------
ERY
Q
N
V
GG
G
C
THW
G
T
IPSKAL
R
HA
V
SR
I
I
E
FNQN
P
L
-
YS
DHSRL
L
RS
S
F
A
D
IL
NH
A
D
N
VINQ
Q
-
T
R
M
RQ
G
FY
ER
N
H
-
CEI
L
Q
G
N
ARF
V
D
E
H
----
TL
A
L
D
C
P
DG
S
VE
TL
T
AEK
F
I
IA
C
GSRP
Y
--
HPT
D
V
DFT
H
PRI
Y
DS
D
S
I
L
S
M
HH
E
P
R
HV
L
I
Y
GAGVIG
C
E
Y
A
S
I
F
RG
MDV
KVDL
I
NT
R
D
RL
L
AF
LD
QE
M
S
DS
L
SYH
F
W
N
SG
VV
I
R
H
N
E
E
Y
E
KI
E
GC
D
---
DGV
I
M
H
L
KS
GKK
--
-
-
--
-
L
KA
D
C
LL
Y
A
N
GR
TG
NT
DS
L
A
L
QNI
G
L
E
T
D
S
RG
Q
L
K
V
N
SMY
Q
T
A
Q
PH
V
YA
V
GDV
I
G
Y
P
S
LA
SA
A
YD
Q
G
R
I
AA
Q
A
L
--
VK
G
E
A
TA
H
LI
--
ED
IP
T
G
IYT
I
PE
ISS
VG
K
TE
QQ
LT
A
M
KV
P
YE
V
G
R
AQ
F
K
HL
A
RA
Q
I
V
G
MNV
G
TL
K
I
L
F
HR
E
T
K
EIL
G
IHCF
G
ER
A
A
E
I
I
H
IG
Q
AIM
E
Q
KGG
G
N
T
I
E
YFV
N
T
TFNY
PT
M
A
E
AYR
V
AA
fig|481805.3.peg.4362
Escherichia coli ATCC 8739 (10-458/466)
I
VIGSGP
G
G
E
G
AA
M
G
L
V
K
QG
A
RV
A
V
I
------
ERY
Q
N
V
GG
G
C
THW
G
T
IPSKAL
R
HA
V
SR
I
I
E
FNQN
P
L
-
YS
DHSRL
L
RS
S
F
A
D
IL
NH
A
D
N
VINQ
Q
-
T
R
M
RQ
G
FY
ER
N
H
-
CEI
L
Q
G
N
ARF
V
D
E
H
----
TL
A
L
D
C
P
DG
S
VE
TL
T
AEK
F
I
IA
C
GSRP
Y
--
HPT
D
V
DFT
H
PRI
Y
DS
D
S
I
L
S
M
HH
E
P
R
HV
L
I
Y
GAGVIG
C
E
Y
A
S
I
F
RG
MDV
KVDL
I
NT
R
D
RL
L
AF
LD
QE
M
S
DS
L
SYH
F
W
N
SG
VV
I
R
H
N
E
E
Y
E
KI
E
GC
D
---
DGV
I
M
H
L
KS
GKK
--
-
-
--
-
L
KA
D
C
LL
Y
A
N
GR
TG
NT
DS
L
A
L
QNI
G
L
E
T
D
S
RG
Q
L
K
V
N
SMY
Q
T
A
Q
PH
V
YA
V
GDV
I
G
Y
P
S
LA
SA
A
YD
Q
G
R
I
AA
Q
A
L
--
VK
G
E
A
TA
H
LI
--
ED
IP
T
G
IYT
I
PE
ISS
VG
K
TE
QQ
LT
A
M
KV
P
YE
V
G
R
AQ
F
K
HL
A
RA
Q
I
V
G
MNV
G
TL
K
I
L
F
HR
E
T
K
EIL
G
IHCF
G
ER
A
A
E
I
I
H
IG
Q
AIM
E
Q
KGG
G
N
T
I
E
YFV
N
T
TFNY
PT
M
A
E
AYR
V
AA
fig|481805.6.peg.4343
Escherichia coli ATCC 8739 (10-458/466)
I
VIGSGP
G
G
E
G
AA
M
G
L
V
K
QG
A
RV
A
V
I
------
ERY
Q
N
V
GG
G
C
THW
G
T
IPSKAL
R
HA
V
SR
I
I
E
FNQN
P
L
-
YS
DHSRL
L
RS
S
F
A
D
IL
NH
A
D
N
VINQ
Q
-
T
R
M
RQ
G
FY
ER
N
H
-
CEI
L
Q
G
N
ARF
V
D
E
H
----
TL
A
L
D
C
P
DG
S
VE
TL
T
AEK
F
I
IA
C
GSRP
Y
--
HPT
D
V
DFT
H
PRI
Y
DS
D
S
I
L
S
M
HH
E
P
R
HV
L
I
Y
GAGVIG
C
E
Y
A
S
I
F
RG
MDV
KVDL
I
NT
R
D
RL
L
AF
LD
QE
M
S
DS
L
SYH
F
W
N
SG
VV
I
R
H
N
E
E
Y
E
KI
E
GC
D
---
DGV
I
M
H
L
KS
GKK
--
-
-
--
-
L
KA
D
C
LL
Y
A
N
GR
TG
NT
DS
L
A
L
QNI
G
L
E
T
D
S
RG
Q
L
K
V
N
SMY
Q
T
A
Q
PH
V
YA
V
GDV
I
G
Y
P
S
LA
SA
A
YD
Q
G
R
I
AA
Q
A
L
--
VK
G
E
A
TA
H
LI
--
ED
IP
T
G
IYT
I
PE
ISS
VG
K
TE
QQ
LT
A
M
KV
P
YE
V
G
R
AQ
F
K
HL
A
RA
Q
I
V
G
MNV
G
TL
K
I
L
F
HR
E
T
K
EIL
G
IHCF
G
ER
A
A
E
I
I
H
IG
Q
AIM
E
Q
KGG
G
N
T
I
E
YFV
N
T
TFNY
PT
M
A
E
AYR
V
AA
fig|331112.3.peg.3919
Escherichia coli HS (10-458/466)
I
VIGSGP
G
G
E
G
AA
M
G
L
V
K
QG
A
RV
A
V
I
------
ERY
Q
N
V
GG
G
C
THW
G
T
IPSKAL
R
HA
V
SR
I
I
E
FNQN
P
L
-
YS
DHSRL
L
RS
S
F
A
D
IL
NH
A
D
N
VINQ
Q
-
T
R
M
RQ
G
FY
ER
N
H
-
CEI
L
Q
G
N
ARF
V
D
E
H
----
TL
A
L
D
C
P
DG
S
VE
TL
T
AEK
F
I
IA
C
GSRP
Y
--
HPT
D
V
DFT
H
PRI
Y
DS
D
S
I
L
S
M
HH
E
P
R
HV
L
I
Y
GAGVIG
C
E
Y
A
S
I
F
RG
MDV
KVDL
I
NT
R
D
RL
L
AF
LD
QE
M
S
DS
L
SYH
F
W
N
SG
VV
I
R
H
N
E
E
Y
E
KI
E
GC
D
---
DGV
I
M
H
L
KS
GKK
--
-
-
--
-
L
KA
D
C
LL
Y
A
N
GR
TG
NT
DS
L
A
L
QNI
G
L
E
T
D
S
RG
Q
L
K
V
N
SMY
Q
T
A
Q
PH
V
YA
V
GDV
I
G
Y
P
S
LA
SA
A
YD
Q
G
R
I
AA
Q
A
L
--
VK
G
E
A
TA
H
LI
--
ED
IP
T
G
IYT
I
PE
ISS
VG
K
TE
QQ
LT
A
M
KV
P
YE
V
G
R
AQ
F
K
HL
A
RA
Q
I
V
G
MNV
G
TL
K
I
L
F
HR
E
T
K
EIL
G
IHCF
G
ER
A
A
E
I
I
H
IG
Q
AIM
E
Q
KGG
G
N
T
I
E
YFV
N
T
TFNY
PT
M
A
E
AYR
V
AA
fig|331112.6.peg.4088
Escherichia coli HS (10-458/466)
I
VIGSGP
G
G
E
G
AA
M
G
L
V
K
QG
A
RV
A
V
I
------
ERY
Q
N
V
GG
G
C
THW
G
T
IPSKAL
R
HA
V
SR
I
I
E
FNQN
P
L
-
YS
DHSRL
L
RS
S
F
A
D
IL
NH
A
D
N
VINQ
Q
-
T
R
M
RQ
G
FY
ER
N
H
-
CEI
L
Q
G
N
ARF
V
D
E
H
----
TL
A
L
D
C
P
DG
S
VE
TL
T
AEK
F
I
IA
C
GSRP
Y
--
HPT
D
V
DFT
H
PRI
Y
DS
D
S
I
L
S
M
HH
E
P
R
HV
L
I
Y
GAGVIG
C
E
Y
A
S
I
F
RG
MDV
KVDL
I
NT
R
D
RL
L
AF
LD
QE
M
S
DS
L
SYH
F
W
N
SG
VV
I
R
H
N
E
E
Y
E
KI
E
GC
D
---
DGV
I
M
H
L
KS
GKK
--
-
-
--
-
L
KA
D
C
LL
Y
A
N
GR
TG
NT
DS
L
A
L
QNI
G
L
E
T
D
S
RG
Q
L
K
V
N
SMY
Q
T
A
Q
PH
V
YA
V
GDV
I
G
Y
P
S
LA
SA
A
YD
Q
G
R
I
AA
Q
A
L
--
VK
G
E
A
TA
H
LI
--
ED
IP
T
G
IYT
I
PE
ISS
VG
K
TE
QQ
LT
A
M
KV
P
YE
V
G
R
AQ
F
K
HL
A
RA
Q
I
V
G
MNV
G
TL
K
I
L
F
HR
E
T
K
EIL
G
IHCF
G
ER
A
A
E
I
I
H
IG
Q
AIM
E
Q
KGG
G
N
T
I
E
YFV
N
T
TFNY
PT
M
A
E
AYR
V
AA
fig|1040638.4.peg.995
Escherichia coli O104:H4 str. LB226692 (10-458/466)
I
VIGSGP
G
G
E
G
AA
M
G
L
V
K
QG
A
RV
A
V
I
------
ERY
Q
N
V
GG
G
C
THW
G
T
IPSKAL
R
HA
V
SR
I
I
E
FNQN
P
L
-
YS
DHSRL
L
RS
S
F
A
D
IL
NH
A
D
N
VINQ
Q
-
T
R
M
RQ
G
FY
ER
N
H
-
CEI
L
Q
G
N
ARF
V
D
E
H
----
TL
A
L
D
C
P
DG
S
VE
TL
T
AEK
F
VIA
C
GSRP
Y
--
HPT
D
V
DFT
H
PRI
Y
DS
D
S
I
L
S
M
HH
E
P
R
HV
L
I
Y
GAGVIG
C
E
Y
A
S
I
F
RG
MDV
KVDL
I
NT
R
D
RL
L
AF
LD
QE
M
S
DS
L
SYH
F
W
N
SG
VV
I
R
H
N
E
E
Y
E
KI
E
GC
D
---
DGV
I
M
H
L
KS
GKK
--
-
-
--
-
L
KA
D
C
LL
Y
A
N
GR
TG
NT
DS
L
A
L
QNI
G
L
E
T
D
S
RG
Q
L
K
V
N
SMY
Q
T
A
Q
PH
V
YA
V
GDV
I
G
Y
P
S
LA
SA
A
YD
Q
G
R
I
AA
Q
A
L
--
VK
G
E
A
TA
H
LI
--
ED
IP
T
G
IYT
I
PE
ISS
VG
K
TE
QQ
LT
A
M
KV
P
YE
V
G
R
AQ
F
K
HL
A
RA
Q
I
V
G
MNV
G
TL
K
I
L
F
HR
E
T
K
EIL
G
IHCF
G
ER
A
A
E
I
I
H
IG
Q
AIM
E
Q
KGG
G
N
T
I
E
YFV
N
T
TFNY
PT
M
A
E
AYR
V
AA
fig|6666666.5357.peg.3574
Escherichia coli TY-2482 (10-458/466)
I
VIGSGP
G
G
E
G
AA
M
G
L
V
K
QG
A
RV
A
V
I
------
ERY
Q
N
V
GG
G
C
THW
G
T
IPSKAL
R
HA
V
SR
I
I
E
FNQN
P
L
-
YS
DHSRL
L
RS
S
F
A
D
IL
NH
A
D
N
VINQ
Q
-
T
R
M
RQ
G
FY
ER
N
H
-
CEI
L
Q
G
N
ARF
V
D
E
H
----
TL
A
L
D
C
P
DG
S
VE
TL
T
AEK
F
VIA
C
GSRP
Y
--
HPT
D
V
DFT
H
PRI
Y
DS
D
S
I
L
S
M
HH
E
P
R
HV
L
I
Y
GAGVIG
C
E
Y
A
S
I
F
RG
MDV
KVDL
I
NT
R
D
RL
L
AF
LD
QE
M
S
DS
L
SYH
F
W
N
SG
VV
I
R
H
N
E
E
Y
E
KI
E
GC
D
---
DGV
I
M
H
L
KS
GKK
--
-
-
--
-
L
KA
D
C
LL
Y
A
N
GR
TG
NT
DS
L
A
L
QNI
G
L
E
T
D
S
RG
Q
L
K
V
N
SMY
Q
T
A
Q
PH
V
YA
V
GDV
I
G
Y
P
S
LA
SA
A
YD
Q
G
R
I
AA
Q
A
L
--
VK
G
E
A
TA
H
LI
--
ED
IP
T
G
IYT
I
PE
ISS
VG
K
TE
QQ
LT
A
M
KV
P
YE
V
G
R
AQ
F
K
HL
A
RA
Q
I
V
G
MNV
G
TL
K
I
L
F
HR
E
T
K
EIL
G
IHCF
G
ER
A
A
E
I
I
H
IG
Q
AIM
E
Q
KGG
G
N
T
I
E
YFV
N
T
TFNY
PT
M
A
E
AYR
V
AA
fig|216592.1.peg.4540
Escherichia coli 042 (10-458/466)
I
VIGSGP
G
G
E
G
AA
M
G
L
V
K
QG
A
RV
A
V
I
------
ERY
Q
N
V
GG
G
C
THW
G
T
IPSKAL
R
HA
V
SR
I
I
E
FNQN
P
L
-
YS
DHSRL
L
RS
S
F
A
D
IL
NH
A
D
N
VINQ
Q
-
T
R
M
RQ
G
FY
ER
N
H
-
CEI
L
Q
G
N
ARF
V
D
E
H
----
TL
A
L
D
C
P
DG
S
VE
TL
T
AEK
F
VIA
C
GSRP
Y
--
HPT
D
V
DFT
H
PRI
Y
DS
D
S
I
L
S
M
HH
E
P
R
HV
L
I
Y
GAGVIG
C
E
Y
A
S
I
F
RG
MDV
KVDL
I
NT
R
D
RL
L
AF
LD
QE
M
S
DS
L
SYH
F
W
N
SG
VV
I
R
H
N
E
E
Y
E
KI
E
GC
D
---
DGV
I
M
H
L
KS
GKK
--
-
-
--
-
L
KA
D
C
LL
Y
A
N
GR
TG
NT
DS
L
A
L
QNI
G
L
E
T
D
S
RG
Q
L
K
V
N
SMY
Q
T
A
Q
PH
V
YA
V
GDV
I
G
Y
P
S
LA
SA
A
YD
Q
G
R
I
AA
Q
A
L
--
VK
G
E
A
TA
H
LI
--
ED
IP
T
G
IYT
I
PE
ISS
VG
K
TE
QQ
LT
A
M
KV
P
YE
V
G
R
AQ
F
K
HL
A
RA
Q
I
V
G
MNV
G
TL
K
I
L
F
HR
E
T
K
EIL
G
IHCF
G
ER
A
A
E
I
I
H
IG
Q
AIM
E
Q
KGG
G
N
T
I
E
YFV
N
T
TFNY
PT
M
A
E
AYR
V
AA
fig|562.373.peg.2656
Escherichia coli 1125A (10-458/466)
I
VIGSGP
G
G
E
G
AA
M
G
L
V
K
QG
A
RV
A
V
I
------
ERY
Q
N
V
GG
G
C
THW
G
T
IPSKAL
R
HA
V
SR
I
I
E
FNQN
P
L
-
YS
DHSRL
L
RS
S
F
A
D
IL
NH
A
D
N
VINQ
Q
-
T
R
M
RQ
G
FY
ER
N
H
-
CEI
L
Q
G
N
ARF
V
D
E
H
----
TL
A
L
D
C
P
DG
S
VE
TL
T
AEK
F
VIA
C
GSRP
Y
--
HPT
D
V
DFT
H
PRI
Y
DS
D
S
I
L
S
M
HH
E
P
R
HV
L
I
Y
GAGVIG
C
E
Y
A
S
I
F
RG
MDV
KVDL
I
NT
R
D
RL
L
AF
LD
QE
M
S
DS
L
SYH
F
W
N
SG
VV
I
R
H
N
E
E
Y
E
KI
E
GC
D
---
DGV
I
M
H
L
KS
GKK
--
-
-
--
-
L
KA
D
C
LL
Y
A
N
GR
TG
NT
DS
L
A
L
QNI
G
L
E
T
D
S
RG
Q
L
K
V
N
SMY
Q
T
A
Q
PH
V
YA
V
GDV
I
G
Y
P
S
LA
SA
A
YD
Q
G
R
I
AA
Q
A
L
--
VK
G
E
A
TA
H
LI
--
ED
IP
T
G
IYT
I
PE
ISS
VG
K
TE
QQ
LT
A
M
KV
P
YE
V
G
R
AQ
F
K
HL
A
RA
Q
I
V
G
MNV
G
TL
K
I
L
F
HR
E
T
K
EIL
G
IHCF
G
ER
A
A
E
I
I
H
IG
Q
AIM
E
Q
KGG
G
N
T
I
E
YFV
N
T
TFNY
PT
M
A
E
AYR
V
AA
fig|562.372.peg.3620
Escherichia coli 1212A (10-458/466)
I
VIGSGP
G
G
E
G
AA
M
G
L
V
K
QG
A
RV
A
V
I
------
ERY
Q
N
V
GG
G
C
THW
G
T
IPSKAL
R
HA
V
SR
I
I
E
FNQN
P
L
-
YS
DHSRL
L
RS
S
F
A
D
IL
NH
A
D
N
VINQ
Q
-
T
R
M
RQ
G
FY
ER
N
H
-
CEI
L
Q
G
N
ARF
V
D
E
H
----
TL
A
L
D
C
P
DG
S
VE
TL
T
AEK
F
VIA
C
GSRP
Y
--
HPT
D
V
DFT
H
PRI
Y
DS
D
S
I
L
S
M
HH
E
P
R
HV
L
I
Y
GAGVIG
C
E
Y
A
S
I
F
RG
MDV
KVDL
I
NT
R
D
RL
L
AF
LD
QE
M
S
DS
L
SYH
F
W
N
SG
VV
I
R
H
N
E
E
Y
E
KI
E
GC
D
---
DGV
I
M
H
L
KS
GKK
--
-
-
--
-
L
KA
D
C
LL
Y
A
N
GR
TG
NT
DS
L
A
L
QNI
G
L
E
T
D
S
RG
Q
L
K
V
N
SMY
Q
T
A
Q
PH
V
YA
V
GDV
I
G
Y
P
S
LA
SA
A
YD
Q
G
R
I
AA
Q
A
L
--
VK
G
E
A
TA
H
LI
--
ED
IP
T
G
IYT
I
PE
ISS
VG
K
TE
QQ
LT
A
M
KV
P
YE
V
G
R
AQ
F
K
HL
A
RA
Q
I
V
G
MNV
G
TL
K
I
L
F
HR
E
T
K
EIL
G
IHCF
G
ER
A
A
E
I
I
H
IG
Q
AIM
E
Q
KGG
G
N
T
I
E
YFV
N
T
TFNY
PT
M
A
E
AYR
V
AA
fig|362663.8.peg.4211
Escherichia coli 536 (10-458/466)
I
VIGSGP
G
G
E
G
AA
M
G
L
V
K
QG
A
RV
A
V
I
------
ERY
Q
N
V
GG
G
C
THW
G
T
IPSKAL
R
HA
V
SR
I
I
E
FNQN
P
L
-
YS
DHSRL
L
RS
S
F
A
D
IL
NH
A
D
N
VINQ
Q
-
T
R
M
RQ
G
FY
ER
N
H
-
CEI
L
Q
G
N
ARF
V
D
E
H
----
TL
A
L
D
C
P
DG
S
VE
TL
T
AEK
F
VIA
C
GSRP
Y
--
HPT
D
V
DFT
H
PRI
Y
DS
D
S
I
L
S
M
HH
E
P
R
HV
L
I
Y
GAGVIG
C
E
Y
A
S
I
F
RG
MDV
KVDL
I
NT
R
D
RL
L
AF
LD
QE
M
S
DS
L
SYH
F
W
N
SG
VV
I
R
H
N
E
E
Y
E
KI
E
GC
D
---
DGV
I
M
H
L
KS
GKK
--
-
-
--
-
L
KA
D
C
LL
Y
A
N
GR
TG
NT
DS
L
A
L
QNI
G
L
E
T
D
S
RG
Q
L
K
V
N
SMY
Q
T
A
Q
PH
V
YA
V
GDV
I
G
Y
P
S
LA
SA
A
YD
Q
G
R
I
AA
Q
A
L
--
VK
G
E
A
TA
H
LI
--
ED
IP
T
G
IYT
I
PE
ISS
VG
K
TE
QQ
LT
T
M
KV
P
YE
V
G
R
AQ
F
K
HL
A
RA
Q
I
V
G
MNV
G
TL
K
I
L
F
HR
E
T
K
EIL
G
IHCF
G
ER
A
A
E
I
I
H
IG
Q
AIM
E
Q
KGG
G
N
T
I
E
YFV
N
T
TFNY
PT
M
A
E
AYR
V
AA
fig|362663.9.peg.4227
Escherichia coli 536 (10-458/466)
I
VIGSGP
G
G
E
G
AA
M
G
L
V
K
QG
A
RV
A
V
I
------
ERY
Q
N
V
GG
G
C
THW
G
T
IPSKAL
R
HA
V
SR
I
I
E
FNQN
P
L
-
YS
DHSRL
L
RS
S
F
A
D
IL
NH
A
D
N
VINQ
Q
-
T
R
M
RQ
G
FY
ER
N
H
-
CEI
L
Q
G
N
ARF
V
D
E
H
----
TL
A
L
D
C
P
DG
S
VE
TL
T
AEK
F
VIA
C
GSRP
Y
--
HPT
D
V
DFT
H
PRI
Y
DS
D
S
I
L
S
M
HH
E
P
R
HV
L
I
Y
GAGVIG
C
E
Y
A
S
I
F
RG
MDV
KVDL
I
NT
R
D
RL
L
AF
LD
QE
M
S
DS
L
SYH
F
W
N
SG
VV
I
R
H
N
E
E
Y
E
KI
E
GC
D
---
DGV
I
M
H
L
KS
GKK
--
-
-
--
-
L
KA
D
C
LL
Y
A
N
GR
TG
NT
DS
L
A
L
QNI
G
L
E
T
D
S
RG
Q
L
K
V
N
SMY
Q
T
A
Q
PH
V
YA
V
GDV
I
G
Y
P
S
LA
SA
A
YD
Q
G
R
I
AA
Q
A
L
--
VK
G
E
A
TA
H
LI
--
ED
IP
T
G
IYT
I
PE
ISS
VG
K
TE
QQ
LT
T
M
KV
P
YE
V
G
R
AQ
F
K
HL
A
RA
Q
I
V
G
MNV
G
TL
K
I
L
F
HR
E
T
K
EIL
G
IHCF
G
ER
A
A
E
I
I
H
IG
Q
AIM
E
Q
KGG
G
N
T
I
E
YFV
N
T
TFNY
PT
M
A
E
AYR
V
AA
fig|562.374.peg.3645
Escherichia coli 536A (10-458/466)
I
VIGSGP
G
G
E
G
AA
M
G
L
V
K
QG
A
RV
A
V
I
------
ERY
Q
N
V
GG
G
C
THW
G
T
IPSKAL
R
HA
V
SR
I
I
E
FNQN
P
L
-
YS
DHSRL
L
RS
S
F
A
D
IL
NH
A
D
N
VINQ
Q
-
T
R
M
RQ
G
FY
ER
N
H
-
CEI
L
Q
G
N
ARF
V
D
E
H
----
TL
A
L
D
C
P
DG
S
VE
TL
T
AEK
F
VIA
C
GSRP
Y
--
HPT
D
V
DFT
H
PRI
Y
DS
D
S
I
L
S
M
HH
E
P
R
HV
L
I
Y
GAGVIG
C
E
Y
A
S
I
F
RG
MDV
KVDL
I
NT
R
D
RL
L
AF
LD
QE
M
S
DS
L
SYH
F
W
N
SG
VV
I
R
H
N
E
E
Y
E
KI
E
GC
D
---
DGV
I
M
H
L
KS
GKK
--
-
-
--
-
L
KA
D
C
LL
Y
A
N
GR
TG
NT
DS
L
A
L
QNI
G
L
E
T
D
S
RG
Q
L
K
V
N
SMY
Q
T
A
Q
PH
V
YA
V
GDV
I
G
Y
P
S
LA
SA
A
YD
Q
G
R
I
AA
Q
A
L
--
VK
G
E
A
TA
H
LI
--
ED
IP
T
G
IYT
I
PE
ISS
VG
K
TE
QQ
LT
A
M
KV
P
YE
V
G
R
AQ
F
K
HL
A
RA
Q
I
V
G
MNV
G
TL
K
I
L
F
HR
E
T
K
EIL
G
IHCF
G
ER
A
A
E
I
I
H
IG
Q
AIM
E
Q
KGG
G
N
T
I
E
YFV
N
T
TFNY
PT
M
A
E
AYR
V
AA
fig|585055.6.peg.4478
Escherichia coli 55989 (10-458/466)
I
VIGSGP
G
G
E
G
AA
M
G
L
V
K
QG
A
RV
A
V
I
------
ERY
Q
N
V
GG
G
C
THW
G
T
IPSKAL
R
HA
V
SR
I
I
E
FNQN
P
L
-
YS
DHSRL
L
RS
S
F
A
D
IL
NH
A
D
N
VINQ
Q
-
T
R
M
RQ
G
FY
ER
N
H
-
CEI
L
Q
G
N
ARF
V
D
E
H
----
TL
A
L
D
C
P
DG
S
VE
TL
T
AEK
F
VIA
C
GSRP
Y
--
HPT
D
V
DFT
H
PRI
Y
DS
D
S
I
L
S
M
HH
E
P
R
HV
L
I
Y
GAGVIG
C
E
Y
A
S
I
F
RG
MDV
KVDL
I
NT
R
D
RL
L
AF
LD
QE
M
S
DS
L
SYH
F
W
N
SG
VV
I
R
H
N
E
E
Y
E
KI
E
GC
D
---
DGV
I
M
H
L
KS
GKK
--
-
-
--
-
L
KA
D
C
LL
Y
A
N
GR
TG
NT
DS
L
A
L
QNI
G
L
E
T
D
S
RG
Q
L
K
V
N
SMY
Q
T
A
Q
PH
V
YA
V
GDV
I
G
Y
P
S
LA
SA
A
YD
Q
G
R
I
AA
Q
A
L
--
VK
G
E
A
TA
H
LI
--
ED
IP
T
G
IYT
I
PE
ISS
VG
K
TE
QQ
LT
A
M
KV
P
YE
V
G
R
AQ
F
K
HL
A
RA
Q
I
V
G
MNV
G
TL
K
I
L
F
HR
E
T
K
EIL
G
IHCF
G
ER
A
A
E
I
I
H
IG
Q
AIM
E
Q
KGG
G
N
T
I
E
YFV
N
T
TFNY
PT
M
A
E
AYR
V
AA
fig|585055.8.peg.4482
Escherichia coli 55989 (10-458/466)
I
VIGSGP
G
G
E
G
AA
M
G
L
V
K
QG
A
RV
A
V
I
------
ERY
Q
N
V
GG
G
C
THW
G
T
IPSKAL
R
HA
V
SR
I
I
E
FNQN
P
L
-
YS
DHSRL
L
RS
S
F
A
D
IL
NH
A
D
N
VINQ
Q
-
T
R
M
RQ
G
FY
ER
N
H
-
CEI
L
Q
G
N
ARF
V
D
E
H
----
TL
A
L
D
C
P
DG
S
VE
TL
T
AEK
F
VIA
C
GSRP
Y
--
HPT
D
V
DFT
H
PRI
Y
DS
D
S
I
L
S
M
HH
E
P
R
HV
L
I
Y
GAGVIG
C
E
Y
A
S
I
F
RG
MDV
KVDL
I
NT
R
D
RL
L
AF
LD
QE
M
S
DS
L
SYH
F
W
N
SG
VV
I
R
H
N
E
E
Y
E
KI
E
GC
D
---
DGV
I
M
H
L
KS
GKK
--
-
-
--
-
L
KA
D
C
LL
Y
A
N
GR
TG
NT
DS
L
A
L
QNI
G
L
E
T
D
S
RG
Q
L
K
V
N
SMY
Q
T
A
Q
PH
V
YA
V
GDV
I
G
Y
P
S
LA
SA
A
YD
Q
G
R
I
AA
Q
A
L
--
VK
G
E
A
TA
H
LI
--
ED
IP
T
G
IYT
I
PE
ISS
VG
K
TE
QQ
LT
A
M
KV
P
YE
V
G
R
AQ
F
K
HL
A
RA
Q
I
V
G
MNV
G
TL
K
I
L
F
HR
E
T
K
EIL
G
IHCF
G
ER
A
A
E
I
I
H
IG
Q
AIM
E
Q
KGG
G
N
T
I
E
YFV
N
T
TFNY
PT
M
A
E
AYR
V
AA
fig|405955.13.peg.4437
Escherichia coli APEC O1 (10-458/466)
I
VIGSGP
G
G
E
G
AA
M
G
L
V
K
QG
A
RV
A
V
I
------
ERY
Q
N
V
GG
G
C
THW
G
T
IPSKAL
R
HA
V
SR
I
I
E
FNQN
P
L
-
YS
DHSRL
L
RS
S
F
A
D
IL
NH
A
D
N
VINQ
Q
-
T
R
M
RQ
G
FY
ER
N
H
-
CEI
L
Q
G
N
ARF
V
D
E
H
----
TL
A
L
D
C
P
DG
S
VE
TL
T
AEK
F
VIA
C
GSRP
Y
--
HPT
D
V
DFT
H
PRI
Y
DS
D
S
I
L
S
M
HH
E
P
R
HV
L
I
Y
GAGVIG
C
E
Y
A
S
I
F
RG
MDV
KVDL
I
NT
R
D
RL
L
AF
LD
QE
M
S
DS
L
SYH
F
W
N
SG
VV
I
R
H
N
E
E
Y
E
KI
E
GC
D
---
DGV
I
M
H
L
KS
GKK
--
-
-
--
-
L
KA
D
C
LL
Y
A
N
GR
TG
NT
DS
L
A
L
QNI
G
L
E
T
D
S
RG
Q
L
K
V
N
SMY
Q
T
A
Q
PH
V
YA
V
GDV
I
G
Y
P
S
LA
SA
A
YD
Q
G
R
I
AA
Q
A
L
--
VK
G
E
A
TA
H
LI
--
ED
IP
T
G
IYT
I
PE
ISS
VG
K
TE
QQ
LT
A
M
KV
P
YE
V
G
R
AQ
F
K
HL
A
RA
Q
I
V
G
MNV
G
TL
K
I
L
F
HR
E
T
K
EIL
G
IHCF
G
ER
A
A
E
I
I
H
IG
Q
AIM
E
Q
KGG
G
N
T
I
E
YFV
N
T
TFNY
PT
M
A
E
AYR
V
AA
fig|405955.9.peg.3736
Escherichia coli APEC O1 (10-458/466)
I
VIGSGP
G
G
E
G
AA
M
G
L
V
K
QG
A
RV
A
V
I
------
ERY
Q
N
V
GG
G
C
THW
G
T
IPSKAL
R
HA
V
SR
I
I
E
FNQN
P
L
-
YS
DHSRL
L
RS
S
F
A
D
IL
NH
A
D
N
VINQ
Q
-
T
R
M
RQ
G
FY
ER
N
H
-
CEI
L
Q
G
N
ARF
V
D
E
H
----
TL
A
L
D
C
P
DG
S
VE
TL
T
AEK
F
VIA
C
GSRP
Y
--
HPT
D
V
DFT
H
PRI
Y
DS
D
S
I
L
S
M
HH
E
P
R
HV
L
I
Y
GAGVIG
C
E
Y
A
S
I
F
RG
MDV
KVDL
I
NT
R
D
RL
L
AF
LD
QE
M
S
DS
L
SYH
F
W
N
SG
VV
I
R
H
N
E
E
Y
E
KI
E
GC
D
---
DGV
I
M
H
L
KS
GKK
--
-
-
--
-
L
KA
D
C
LL
Y
A
N
GR
TG
NT
DS
L
A
L
QNI
G
L
E
T
D
S
RG
Q
L
K
V
N
SMY
Q
T
A
Q
PH
V
YA
V
GDV
I
G
Y
P
S
LA
SA
A
YD
Q
G
R
I
AA
Q
A
L
--
VK
G
E
A
TA
H
LI
--
ED
IP
T
G
IYT
I
PE
ISS
VG
K
TE
QQ
LT
A
M
KV
P
YE
V
G
R
AQ
F
K
HL
A
RA
Q
I
V
G
MNV
G
TL
K
I
L
F
HR
E
T
K
EIL
G
IHCF
G
ER
A
A
E
I
I
H
IG
Q
AIM
E
Q
KGG
G
N
T
I
E
YFV
N
T
TFNY
PT
M
A
E
AYR
V
AA
fig|344601.3.peg.3729
Escherichia coli B171 (10-458/466)
I
VIGSGP
G
G
E
G
AA
M
G
L
V
K
QG
A
RV
A
V
I
------
ERY
Q
N
V
GG
G
C
THW
G
T
IPSKAL
R
HA
V
SR
I
I
E
FNQN
P
L
-
YS
DHSRL
L
RS
S
F
A
D
IL
NH
A
D
N
VINQ
Q
-
T
R
M
RQ
G
FY
ER
N
H
-
CEI
L
Q
G
N
ARF
V
D
E
H
----
TL
A
L
D
C
P
DG
S
VE
TL
T
AEK
F
VIA
C
GSRP
Y
--
HPT
D
V
DFT
H
PRI
Y
DS
D
S
I
L
S
M
HH
E
P
R
HV
L
I
Y
GAGVIG
C
E
Y
A
S
I
F
RG
MDV
KVDL
I
NT
R
D
RL
L
AF
LD
QE
M
S
DS
L
SYH
F
W
N
SG
VV
I
R
H
N
E
E
Y
E
KI
E
GC
D
---
DGV
I
M
H
L
KS
GKK
--
-
-
--
-
L
KA
D
C
LL
Y
A
N
GR
TG
NT
DS
L
A
L
QNI
G
L
E
T
D
S
RG
Q
L
K
V
N
SMY
Q
T
A
Q
PH
V
YA
V
GDV
I
G
Y
P
S
LA
SA
A
YD
Q
G
R
I
AA
Q
A
L
--
VK
G
E
A
TA
H
LI
--
ED
IP
T
G
IYT
I
PE
ISS
VG
K
TE
QQ
LT
A
M
KV
P
YE
V
G
R
AQ
F
K
HL
A
RA
Q
I
V
G
MNV
G
TL
K
I
L
F
HR
E
T
K
EIL
G
IHCF
G
ER
A
A
E
I
I
H
IG
Q
AIM
E
Q
KGG
G
N
T
I
E
YFV
N
T
TFNY
PT
M
A
E
AYR
V
AA
fig|344601.5.peg.3899
Escherichia coli B171 (10-458/466)
I
VIGSGP
G
G
E
G
AA
M
G
L
V
K
QG
A
RV
A
V
I
------
ERY
Q
N
V
GG
G
C
THW
G
T
IPSKAL
R
HA
V
SR
I
I
E
FNQN
P
L
-
YS
DHSRL
L
RS
S
F
A
D
IL
NH
A
D
N
VINQ
Q
-
T
R
M
RQ
G
FY
ER
N
H
-
CEI
L
Q
G
N
ARF
V
D
E
H
----
TL
A
L
D
C
P
DG
S
VE
TL
T
AEK
F
VIA
C
GSRP
Y
--
HPT
D
V
DFT
H
PRI
Y
DS
D
S
I
L
S
M
HH
E
P
R
HV
L
I
Y
GAGVIG
C
E
Y
A
S
I
F
RG
MDV
KVDL
I
NT
R
D
RL
L
AF
LD
QE
M
S
DS
L
SYH
F
W
N
SG
VV
I
R
H
N
E
E
Y
E
KI
E
GC
D
---
DGV
I
M
H
L
KS
GKK
--
-
-
--
-
L
KA
D
C
LL
Y
A
N
GR
TG
NT
DS
L
A
L
QNI
G
L
E
T
D
S
RG
Q
L
K
V
N
SMY
Q
T
A
Q
PH
V
YA
V
GDV
I
G
Y
P
S
LA
SA
A
YD
Q
G
R
I
AA
Q
A
L
--
VK
G
E
A
TA
H
LI
--
ED
IP
T
G
IYT
I
PE
ISS
VG
K
TE
QQ
LT
A
M
KV
P
YE
V
G
R
AQ
F
K
HL
A
RA
Q
I
V
G
MNV
G
TL
K
I
L
F
HR
E
T
K
EIL
G
IHCF
G
ER
A
A
E
I
I
H
IG
Q
AIM
E
Q
KGG
G
N
T
I
E
YFV
N
T
TFNY
PT
M
A
E
AYR
V
AA
fig|550676.3.peg.4224
Escherichia coli B185 (10-458/466)
I
VIGSGP
G
G
E
G
AA
M
G
L
V
K
QG
A
RV
A
V
I
------
ERY
Q
N
V
GG
G
C
THW
G
T
IPSKAL
R
HA
V
SR
I
I
E
FNQN
P
L
-
YS
DHSRL
L
RS
S
F
A
D
IL
NH
A
D
N
VINQ
Q
-
T
R
M
RQ
G
FY
ER
N
H
-
CEI
L
Q
G
N
ARF
V
D
E
H
----
TL
A
L
D
C
P
DG
S
VE
TL
T
AEK
F
VIA
C
GSRP
Y
--
HPT
D
V
DFT
H
PRI
Y
DS
D
S
I
L
S
M
HH
E
P
R
HV
L
I
Y
GAGVIG
C
E
Y
A
S
I
F
RG
MDV
KVDL
I
NT
R
D
RL
L
AF
LD
QE
M
S
DS
L
SYH
F
W
N
SG
VV
I
R
H
N
E
E
Y
E
KI
E
GC
D
---
DGV
I
M
H
L
KS
GKK
--
-
-
--
-
L
KA
D
C
LL
Y
A
N
GR
TG
NT
DS
L
A
L
QNI
G
L
E
T
D
S
RG
Q
L
K
V
N
SMY
Q
T
A
Q
PH
V
YA
V
GDV
I
G
Y
P
S
LA
SA
A
YD
Q
G
R
I
AA
Q
A
L
--
VK
G
E
A
TA
H
LI
--
ED
IP
T
G
IYT
I
PE
ISS
VG
K
TE
QQ
LT
A
M
KV
P
YE
V
G
R
AQ
F
K
HL
A
RA
Q
I
V
G
MNV
G
TL
K
I
L
F
HR
E
T
K
EIL
G
IHCF
G
ER
A
A
E
I
I
H
IG
Q
AIM
E
Q
KGG
G
N
T
I
E
YFV
N
T
TFNY
PT
M
A
E
AYR
V
AA
fig|340184.3.peg.4669
Escherichia coli B7A (10-458/466)
I
VIGSGP
G
G
E
G
AA
M
G
L
V
K
QG
A
RV
A
V
I
------
ERY
Q
N
V
GG
G
C
THW
G
T
IPSKAL
R
HA
V
SR
I
I
E
FNQN
P
L
-
YS
DHSRL
L
RS
S
F
A
D
IL
NH
A
D
N
VINQ
Q
-
T
R
M
RQ
G
FY
ER
N
H
-
CEI
L
Q
G
N
ARF
V
D
E
H
----
TL
A
L
D
C
P
DG
S
VE
TL
T
AEK
F
VIA
C
GSRP
Y
--
HPT
D
V
DFT
H
PRI
Y
DS
D
S
I
L
S
M
HH
E
P
R
HV
L
I
Y
GAGVIG
C
E
Y
A
S
I
F
RG
MDV
KVDL
I
NT
R
D
RL
L
AF
LD
QE
M
S
DS
L
SYH
F
W
N
SG
VV
I
R
H
N
E
E
Y
E
KI
E
GC
D
---
DGV
I
M
H
L
KS
GKK
--
-
-
--
-
L
KA
D
C
LL
Y
A
N
GR
TG
NT
DS
L
A
L
QNI
G
L
E
T
D
S
RG
Q
L
K
V
N
SMY
Q
T
A
Q
PH
V
YA
V
GDV
I
G
Y
P
S
LA
SA
A
YD
Q
G
R
I
AA
Q
A
L
--
VK
G
E
A
TA
H
LI
--
ED
IP
T
G
IYT
I
PE
ISS
VG
K
TE
QQ
LT
A
M
KV
P
YE
V
G
R
AQ
F
K
HL
A
RA
Q
I
V
G
MNV
G
TL
K
I
L
F
HR
E
T
K
EIL
G
IHCF
G
ER
A
A
E
I
I
H
IG
Q
AIM
E
Q
KGG
G
N
T
I
E
YFV
N
T
TFNY
PT
M
A
E
AYR
V
AA
fig|595496.3.peg.3967
Escherichia coli BW2952 (10-458/466)
I
VIGSGP
G
G
E
G
AA
M
G
L
V
K
QG
A
RV
A
V
I
------
ERY
Q
N
V
GG
G
C
THW
G
T
IPSKAL
R
HA
V
SR
I
I
E
FNQN
P
L
-
YS
DHSRL
L
RS
S
F
A
D
IL
NH
A
D
N
VINQ
Q
-
T
R
M
RQ
G
FY
ER
N
H
-
CEI
L
Q
G
N
ARF
V
D
E
H
----
TL
A
L
D
C
P
DG
S
VE
TL
T
AEK
F
VIA
C
GSRP
Y
--
HPT
D
V
DFT
H
PRI
Y
DS
D
S
I
L
S
M
HH
E
P
R
HV
L
I
Y
GAGVIG
C
E
Y
A
S
I
F
RG
MDV
KVDL
I
NT
R
D
RL
L
AF
LD
QE
M
S
DS
L
SYH
F
W
N
SG
VV
I
R
H
N
E
E
Y
E
KI
E
GC
D
---
DGV
I
M
H
L
KS
GKK
--
-
-
--
-
L
KA
D
C
LL
Y
A
N
GR
TG
NT
DS
L
A
L
QNI
G
L
E
T
D
S
RG
Q
L
K
V
N
SMY
Q
T
A
Q
PH
V
YA
V
GDV
I
G
Y
P
S
LA
SA
A
YD
Q
G
R
I
AA
Q
A
L
--
VK
G
E
A
TA
H
LI
--
ED
IP
T
G
IYT
I
PE
ISS
VG
K
TE
QQ
LT
A
M
KV
P
YE
V
G
R
AQ
F
K
HL
A
RA
Q
I
V
G
MNV
G
TL
K
I
L
F
HR
E
T
K
EIL
G
IHCF
G
ER
A
A
E
I
I
H
IG
Q
AIM
E
Q
KGG
G
N
T
I
E
YFV
N
T
TFNY
PT
M
A
E
AYR
V
AA
fig|536056.3.peg.4277
Escherichia coli DH1 (10-458/466)
I
VIGSGP
G
G
E
G
AA
M
G
L
V
K
QG
A
RV
A
V
I
------
ERY
Q
N
V
GG
G
C
THW
G
T
IPSKAL
R
HA
V
SR
I
I
E
FNQN
P
L
-
YS
DHSRL
L
RS
S
F
A
D
IL
NH
A
D
N
VINQ
Q
-
T
R
M
RQ
G
FY
ER
N
H
-
CEI
L
Q
G
N
ARF
V
D
E
H
----
TL
A
L
D
C
P
DG
S
VE
TL
T
AEK
F
VIA
C
GSRP
Y
--
HPT
D
V
DFT
H
PRI
Y
DS
D
S
I
L
S
M
HH
E
P
R
HV
L
I
Y
GAGVIG
C
E
Y
A
S
I
F
RG
MDV
KVDL
I
NT
R
D
RL
L
AF
LD
QE
M
S
DS
L
SYH
F
W
N
SG
VV
I
R
H
N
E
E
Y
E
KI
E
GC
D
---
DGV
I
M
H
L
KS
GKK
--
-
-
--
-
L
KA
D
C
LL
Y
A
N
GR
TG
NT
DS
L
A
L
QNI
G
L
E
T
D
S
RG
Q
L
K
V
N
SMY
Q
T
A
Q
PH
V
YA
V
GDV
I
G
Y
P
S
LA
SA
A
YD
Q
G
R
I
AA
Q
A
L
--
VK
G
E
A
TA
H
LI
--
ED
IP
T
G
IYT
I
PE
ISS
VG
K
TE
QQ
LT
A
M
KV
P
YE
V
G
R
AQ
F
K
HL
A
RA
Q
I
V
G
MNV
G
TL
K
I
L
F
HR
E
T
K
EIL
G
IHCF
G
ER
A
A
E
I
I
H
IG
Q
AIM
E
Q
KGG
G
N
T
I
E
YFV
N
T
TFNY
PT
M
A
E
AYR
V
AA
fig|340185.3.peg.2242
Escherichia coli E22 (10-458/466)
I
VIGSGP
G
G
E
G
AA
M
G
L
V
K
QG
A
RV
A
V
I
------
ERY
Q
N
V
GG
G
C
THW
G
T
IPSKAL
R
HA
V
SR
I
I
E
FNQN
P
L
-
YS
DHSRL
L
RS
S
F
A
D
IL
NH
A
D
N
VINQ
Q
-
T
R
M
RQ
G
FY
ER
N
H
-
CEI
L
Q
G
N
ARF
V
D
E
H
----
TL
A
L
D
C
P
DG
S
VE
TL
T
AEK
F
VIA
C
GSRP
Y
--
HPT
D
V
DFT
H
PRI
Y
DS
D
S
I
L
S
M
HH
E
P
R
HV
L
I
Y
GAGVIG
C
E
Y
A
S
I
F
RG
MDV
KVDL
I
NT
R
D
RL
L
AF
LD
QE
M
S
DS
L
SYH
F
W
N
SG
VV
I
R
H
N
E
E
Y
E
KI
E
GC
D
---
DGV
I
M
H
L
KS
GKK
--
-
-
--
-
L
KA
D
C
LL
Y
A
N
GR
TG
NT
DS
L
A
L
QNI
G
L
E
T
D
S
RG
Q
L
K
V
N
SMY
Q
T
A
Q
PH
V
YA
V
GDV
I
G
Y
P
S
LA
SA
A
YD
Q
G
R
I
AA
Q
A
L
--
VK
G
E
A
TA
H
LI
--
ED
IP
T
G
IYT
I
PE
ISS
VG
K
TE
QQ
LT
A
M
KV
P
YE
V
G
R
AQ
F
K
HL
A
RA
Q
I
V
G
MNV
G
TL
K
I
L
F
HR
E
T
K
EIL
G
IHCF
G
ER
A
A
E
I
I
H
IG
Q
AIM
E
Q
KGG
G
N
T
I
E
YFV
N
T
TFNY
PT
M
A
E
AYR
V
AA
fig|340185.4.peg.2371
Escherichia coli E22 (10-458/466)
I
VIGSGP
G
G
E
G
AA
M
G
L
V
K
QG
A
RV
A
V
I
------
ERY
Q
N
V
GG
G
C
THW
G
T
IPSKAL
R
HA
V
SR
I
I
E
FNQN
P
L
-
YS
DHSRL
L
RS
S
F
A
D
IL
NH
A
D
N
VINQ
Q
-
T
R
M
RQ
G
FY
ER
N
H
-
CEI
L
Q
G
N
ARF
V
D
E
H
----
TL
A
L
D
C
P
DG
S
VE
TL
T
AEK
F
VIA
C
GSRP
Y
--
HPT
D
V
DFT
H
PRI
Y
DS
D
S
I
L
S
M
HH
E
P
R
HV
L
I
Y
GAGVIG
C
E
Y
A
S
I
F
RG
MDV
KVDL
I
NT
R
D
RL
L
AF
LD
QE
M
S
DS
L
SYH
F
W
N
SG
VV
I
R
H
N
E
E
Y
E
KI
E
GC
D
---
DGV
I
M
H
L
KS
GKK
--
-
-
--
-
L
KA
D
C
LL
Y
A
N
GR
TG
NT
DS
L
A
L
QNI
G
L
E
T
D
S
RG
Q
L
K
V
N
SMY
Q
T
A
Q
PH
V
YA
V
GDV
I
G
Y
P
S
LA
SA
A
YD
Q
G
R
I
AA
Q
A
L
--
VK
G
E
A
TA
H
LI
--
ED
IP
T
G
IYT
I
PE
ISS
VG
K
TE
QQ
LT
A
M
KV
P
YE
V
G
R
AQ
F
K
HL
A
RA
Q
I
V
G
MNV
G
TL
K
I
L
F
HR
E
T
K
EIL
G
IHCF
G
ER
A
A
E
I
I
H
IG
Q
AIM
E
Q
KGG
G
N
T
I
E
YFV
N
T
TFNY
PT
M
A
E
AYR
V
AA
fig|331111.12.peg.4724
Escherichia coli E24377A (10-458/466)
I
VIGSGP
G
G
E
G
AA
M
G
L
V
K
QG
A
RV
A
V
I
------
ERY
Q
N
V
GG
G
C
THW
G
T
IPSKAL
R
HA
V
SR
I
I
E
FNQN
P
L
-
YS
DHSRL
L
RS
S
F
A
D
IL
NH
A
D
N
VINQ
Q
-
T
R
M
RQ
G
FY
ER
N
H
-
CEI
L
Q
G
N
ARF
V
D
E
H
----
TL
A
L
D
C
P
DG
S
VE
TL
T
AEK
F
VIA
C
GSRP
Y
--
HPT
D
V
DFT
H
PRI
Y
DS
D
S
I
L
S
M
HH
E
P
R
HV
L
I
Y
GAGVIG
C
E
Y
A
S
I
F
RG
MDV
KVDL
I
NT
R
D
RL
L
AF
LD
QE
M
S
DS
L
SYH
F
W
N
SG
VV
I
R
H
N
E
E
Y
E
KI
E
GC
D
---
DGV
I
M
H
L
KS
GKK
--
-
-
--
-
L
KA
D
C
LL
Y
A
N
GR
TG
NT
DS
L
A
L
QNI
G
L
E
T
D
S
RG
Q
L
K
V
N
SMY
Q
T
A
Q
PH
V
YA
V
GDV
I
G
Y
P
S
LA
SA
A
YD
Q
G
R
I
AA
Q
A
L
--
VK
G
E
A
TA
H
LI
--
ED
IP
T
G
IYT
I
PE
ISS
VG
K
TE
QQ
LT
A
M
KV
P
YE
V
G
R
AQ
F
K
HL
A
RA
Q
I
V
G
MNV
G
TL
K
I
L
F
HR
E
T
K
EIL
G
IHCF
G
ER
A
A
E
I
I
H
IG
Q
AIM
E
Q
KGG
G
N
T
I
E
YFV
N
T
TFNY
PT
M
A
E
AYR
V
AA
fig|331111.3.peg.2117
Escherichia coli E24377A (10-458/466)
I
VIGSGP
G
G
E
G
AA
M
G
L
V
K
QG
A
RV
A
V
I
------
ERY
Q
N
V
GG
G
C
THW
G
T
IPSKAL
R
HA
V
SR
I
I
E
FNQN
P
L
-
YS
DHSRL
L
RS
S
F
A
D
IL
NH
A
D
N
VINQ
Q
-
T
R
M
RQ
G
FY
ER
N
H
-
CEI
L
Q
G
N
ARF
V
D
E
H
----
TL
A
L
D
C
P
DG
S
VE
TL
T
AEK
F
VIA
C
GSRP
Y
--
HPT
D
V
DFT
H
PRI
Y
DS
D
S
I
L
S
M
HH
E
P
R
HV
L
I
Y
GAGVIG
C
E
Y
A
S
I
F
RG
MDV
KVDL
I
NT
R
D
RL
L
AF
LD
QE
M
S
DS
L
SYH
F
W
N
SG
VV
I
R
H
N
E
E
Y
E
KI
E
GC
D
---
DGV
I
M
H
L
KS
GKK
--
-
-
--
-
L
KA
D
C
LL
Y
A
N
GR
TG
NT
DS
L
A
L
QNI
G
L
E
T
D
S
RG
Q
L
K
V
N
SMY
Q
T
A
Q
PH
V
YA
V
GDV
I
G
Y
P
S
LA
SA
A
YD
Q
G
R
I
AA
Q
A
L
--
VK
G
E
A
TA
H
LI
--
ED
IP
T
G
IYT
I
PE
ISS
VG
K
TE
QQ
LT
A
M
KV
P
YE
V
G
R
AQ
F
K
HL
A
RA
Q
I
V
G
MNV
G
TL
K
I
L
F
HR
E
T
K
EIL
G
IHCF
G
ER
A
A
E
I
I
H
IG
Q
AIM
E
Q
KGG
G
N
T
I
E
YFV
N
T
TFNY
PT
M
A
E
AYR
V
AA
fig|562.375.peg.7
Escherichia coli EC4100B (10-458/466)
I
VIGSGP
G
G
E
G
AA
M
G
L
V
K
QG
A
RV
A
V
I
------
ERY
Q
N
V
GG
G
C
THW
G
T
IPSKAL
R
HA
V
SR
I
I
E
FNQN
P
L
-
YS
DHSRL
L
RS
S
F
A
D
IL
NH
A
D
N
VINQ
Q
-
T
R
M
RQ
G
FY
ER
N
H
-
CEI
L
Q
G
N
ARF
V
D
E
H
----
TL
A
L
D
C
P
DG
S
VE
TL
T
AEK
F
VIA
C
GSRP
Y
--
HPT
D
V
DFT
H
PRI
Y
DS
D
S
I
L
S
M
HH
E
P
R
HV
L
I
Y
GAGVIG
C
E
Y
A
S
I
F
RG
MDV
KVDL
I
NT
R
D
RL
L
AF
LD
QE
M
S
DS
L
SYH
F
W
N
SG
VV
I
R
H
N
E
E
Y
E
KI
E
GC
D
---
DGV
I
M
H
L
KS
GKK
--
-
-
--
-
L
KA
D
C
LL
Y
A
N
GR
TG
NT
DS
L
A
L
QNI
G
L
E
T
D
S
RG
Q
L
K
V
N
SMY
Q
T
A
Q
PH
V
YA
V
GDV
I
G
Y
P
S
LA
SA
A
YD
Q
G
R
I
AA
Q
A
L
--
VK
G
E
A
TA
H
LI
--
ED
IP
T
G
IYT
I
PE
ISS
VG
K
TE
QQ
LT
A
M
KV
P
YE
V
G
R
AQ
F
K
HL
A
RA
Q
I
V
G
MNV
G
TL
K
I
L
F
HR
E
T
K
EIL
G
IHCF
G
ER
A
A
E
I
I
H
IG
Q
AIM
E
Q
KGG
G
N
T
I
E
YFV
N
T
TFNY
PT
M
A
E
AYR
V
AA
fig|316401.4.peg.4801
Escherichia coli ETEC H10407 (10-458/466)
I
VIGSGP
G
G
E
G
AA
M
G
L
V
K
QG
A
RV
A
V
I
------
ERY
Q
N
V
GG
G
C
THW
G
T
IPSKAL
R
HA
V
SR
I
I
E
FNQN
P
L
-
YS
DHSRL
L
RS
S
F
A
D
IL
NH
A
D
N
VINQ
Q
-
T
R
M
RQ
G
FY
ER
N
H
-
CEI
L
Q
G
N
ARF
V
D
E
H
----
TL
A
L
D
C
P
DG
S
VE
TL
T
AEK
F
VIA
C
GSRP
Y
--
HPT
D
V
DFT
H
PRI
Y
DS
D
S
I
L
S
M
HH
E
P
R
HV
L
I
Y
GAGVIG
C
E
Y
A
S
I
F
RG
MDV
KVDL
I
NT
R
D
RL
L
AF
LD
QE
M
S
DS
L
SYH
F
W
N
SG
VV
I
R
H
N
E
E
Y
E
KI
E
GC
D
---
DGV
I
M
H
L
KS
GKK
--
-
-
--
-
L
KA
D
C
LL
Y
A
N
GR
TG
NT
DS
L
A
L
QNI
G
L
E
T
D
S
RG
Q
L
K
V
N
SMY
Q
T
A
Q
PH
V
YA
V
GDV
I
G
Y
P
S
LA
SA
A
YD
Q
G
R
I
AA
Q
A
L
--
VK
G
E
A
TA
H
LI
--
ED
IP
T
G
IYT
I
PE
ISS
VG
K
TE
QQ
LT
A
M
KV
P
YE
V
G
R
AQ
F
K
HL
A
RA
Q
I
V
G
MNV
G
TL
K
I
L
F
HR
E
T
K
EIL
G
IHCF
G
ER
A
A
E
I
I
H
IG
Q
AIM
E
Q
KGG
G
N
T
I
E
YFV
N
T
TFNY
PT
M
A
E
AYR
V
AA
fig|340197.3.peg.2845
Escherichia coli F11 (10-458/466)
I
VIGSGP
G
G
E
G
AA
M
G
L
V
K
QG
A
RV
A
V
I
------
ERY
Q
N
V
GG
G
C
THW
G
T
IPSKAL
R
HA
V
SR
I
I
E
FNQN
P
L
-
YS
DHSRL
L
RS
S
F
A
D
IL
NH
A
D
N
VINQ
Q
-
T
R
M
RQ
G
FY
ER
N
H
-
CEI
L
Q
G
N
ARF
V
D
E
H
----
TL
A
L
D
C
P
DG
S
VE
TL
T
AEK
F
VIA
C
GSRP
Y
--
HPT
D
V
DFT
H
PRI
Y
DS
D
S
I
L
S
M
HH
E
P
R
HV
L
I
Y
GAGVIG
C
E
Y
A
S
I
F
RG
MDV
KVDL
I
NT
R
D
RL
L
AF
LD
QE
M
S
DS
L
SYH
F
W
N
SG
VV
I
R
H
N
E
E
Y
E
KI
E
GC
D
---
DGV
I
M
H
L
KS
GKK
--
-
-
--
-
L
KA
D
C
LL
Y
A
N
GR
TG
NT
DS
L
A
L
QNI
G
L
E
T
D
S
RG
Q
L
K
V
N
SMY
Q
T
A
Q
PH
V
YA
V
GDV
I
G
Y
P
S
LA
SA
A
YD
Q
G
R
I
AA
Q
A
L
--
VK
G
E
A
TA
H
LI
--
ED
IP
T
G
IYT
I
PE
ISS
VG
K
TE
QQ
LT
T
M
KV
P
YE
V
G
R
AQ
F
K
HL
A
RA
Q
I
V
G
MNV
G
TL
K
I
L
F
HR
E
T
K
EIL
G
IHCF
G
ER
A
A
E
I
I
H
IG
Q
AIM
E
Q
KGG
G
N
T
I
E
YFV
N
T
TFNY
PT
M
A
E
AYR
V
AA
fig|340197.5.peg.2975
Escherichia coli F11 (10-458/466)
I
VIGSGP
G
G
E
G
AA
M
G
L
V
K
QG
A
RV
A
V
I
------
ERY
Q
N
V
GG
G
C
THW
G
T
IPSKAL
R
HA
V
SR
I
I
E
FNQN
P
L
-
YS
DHSRL
L
RS
S
F
A
D
IL
NH
A
D
N
VINQ
Q
-
T
R
M
RQ
G
FY
ER
N
H
-
CEI
L
Q
G
N
ARF
V
D
E
H
----
TL
A
L
D
C
P
DG
S
VE
TL
T
AEK
F
VIA
C
GSRP
Y
--
HPT
D
V
DFT
H
PRI
Y
DS
D
S
I
L
S
M
HH
E
P
R
HV
L
I
Y
GAGVIG
C
E
Y
A
S
I
F
RG
MDV
KVDL
I
NT
R
D
RL
L
AF
LD
QE
M
S
DS
L
SYH
F
W
N
SG
VV
I
R
H
N
E
E
Y
E
KI
E
GC
D
---
DGV
I
M
H
L
KS
GKK
--
-
-
--
-
L
KA
D
C
LL
Y
A
N
GR
TG
NT
DS
L
A
L
QNI
G
L
E
T
D
S
RG
Q
L
K
V
N
SMY
Q
T
A
Q
PH
V
YA
V
GDV
I
G
Y
P
S
LA
SA
A
YD
Q
G
R
I
AA
Q
A
L
--
VK
G
E
A
TA
H
LI
--
ED
IP
T
G
IYT
I
PE
ISS
VG
K
TE
QQ
LT
T
M
KV
P
YE
V
G
R
AQ
F
K
HL
A
RA
Q
I
V
G
MNV
G
TL
K
I
L
F
HR
E
T
K
EIL
G
IHCF
G
ER
A
A
E
I
I
H
IG
Q
AIM
E
Q
KGG
G
N
T
I
E
YFV
N
T
TFNY
PT
M
A
E
AYR
V
AA
fig|656379.3.peg.5212
Escherichia coli FVEC1302 (10-458/466)
I
VIGSGP
G
G
E
G
AA
M
G
L
V
K
QG
A
RV
A
V
I
------
ERY
Q
N
V
GG
G
C
THW
G
T
IPSKAL
R
HA
V
SR
I
I
E
FNQN
P
L
-
YS
DHSRL
L
RS
S
F
A
D
IL
NH
A
D
N
VINQ
Q
-
T
R
M
RQ
G
FY
ER
N
H
-
CEI
L
Q
G
N
ARF
V
D
E
H
----
TL
A
L
D
C
P
DG
S
VE
TL
T
AEK
F
VIA
C
GSRP
Y
--
HPT
D
V
DFT
H
PRI
Y
DS
D
S
I
L
S
M
HH
E
P
R
HV
L
I
Y
GAGVIG
C
E
Y
A
S
I
F
RG
MDV
KVDL
I
NT
R
D
RL
L
AF
LD
QE
M
S
DS
L
SYH
F
W
N
SG
VV
I
R
H
N
E
E
Y
E
KI
E
GC
D
---
DGV
I
M
H
L
KS
GKK
--
-
-
--
-
L
KA
D
C
LL
Y
A
N
GR
TG
NT
DS
L
A
L
QNI
G
L
E
T
D
S
RG
Q
L
K
V
N
SMY
Q
T
A
Q
PH
V
YA
V
GDV
I
G
Y
P
S
LA
SA
A
YD
Q
G
R
I
AA
Q
A
L
--
VK
G
E
A
TA
H
LI
--
ED
IP
T
G
IYT
I
PE
ISS
VG
K
TE
QQ
LT
A
M
KV
P
YE
V
G
R
AQ
F
K
HL
A
RA
Q
I
V
G
MNV
G
TL
K
I
L
F
HR
E
T
K
EIL
G
IHCF
G
ER
A
A
E
I
I
H
IG
Q
AIM
E
Q
KGG
G
N
T
I
E
YFV
N
T
TFNY
PT
M
A
E
AYR
V
AA
fig|656380.3.peg.5104
Escherichia coli FVEC1412 (10-458/466)
I
VIGSGP
G
G
E
G
AA
M
G
L
V
K
QG
A
RV
A
V
I
------
ERY
Q
N
V
GG
G
C
THW
G
T
IPSKAL
R
HA
V
SR
I
I
E
FNQN
P
L
-
YS
DHSRL
L
RS
S
F
A
D
IL
NH
A
D
N
VINQ
Q
-
T
R
M
RQ
G
FY
ER
N
H
-
CEI
L
Q
G
N
ARF
V
D
E
H
----
TL
A
L
D
C
P
DG
S
VE
TL
T
AEK
F
VIA
C
GSRP
Y
--
HPT
D
V
DFT
H
PRI
Y
DS
D
S
I
L
S
M
HH
E
P
R
HV
L
I
Y
GAGVIG
C
E
Y
A
S
I
F
RG
MDV
KVDL
I
NT
R
D
RL
L
AF
LD
QE
M
S
DS
L
SYH
F
W
N
SG
VV
I
R
H
N
E
E
Y
E
KI
E
GC
D
---
DGV
I
M
H
L
KS
GKK
--
-
-
--
-
L
KA
D
C
LL
Y
A
N
GR
TG
NT
DS
L
A
L
QNI
G
L
E
T
D
S
RG
Q
L
K
V
N
SMY
Q
T
A
Q
PH
V
YA
V
GDV
I
G
Y
P
S
LA
SA
A
YD
Q
G
R
I
AA
Q
A
L
--
VK
G
E
A
TA
H
LI
--
ED
IP
T
G
IYT
I
PE
ISS
VG
K
TE
QQ
LT
A
M
KV
P
YE
V
G
R
AQ
F
K
HL
A
RA
Q
I
V
G
MNV
G
TL
K
I
L
F
HR
E
T
K
EIL
G
IHCF
G
ER
A
A
E
I
I
H
IG
Q
AIM
E
Q
KGG
G
N
T
I
E
YFV
N
T
TFNY
PT
M
A
E
AYR
V
AA
fig|656393.3.peg.5168
Escherichia coli H299 (10-458/466)
I
VIGSGP
G
G
E
G
AA
M
G
L
V
K
QG
A
RV
A
V
I
------
ERY
Q
N
V
GG
G
C
THW
G
T
IPSKAL
R
HA
V
SR
I
I
E
FNQN
P
L
-
YS
DHSRL
L
RS
S
F
A
D
IL
NH
A
D
N
VINQ
Q
-
T
R
M
RQ
G
FY
ER
N
H
-
CEI
L
Q
G
N
ARF
V
D
E
H
----
TL
A
L
D
C
P
DG
S
VE
TL
T
AEK
F
VIA
C
GSRP
Y
--
HPT
D
V
DFT
H
PRI
Y
DS
D
S
I
L
S
M
HH
E
P
R
HV
L
I
Y
GAGVIG
C
E
Y
A
S
I
F
RG
MDV
KVDL
I
NT
R
D
RL
L
AF
LD
QE
M
S
DS
L
SYH
F
W
N
SG
VV
I
R
H
N
E
E
Y
E
KI
E
GC
D
---
DGV
I
M
H
L
KS
GKK
--
-
-
--
-
L
KA
D
C
LL
Y
A
N
GR
TG
NT
DS
L
A
L
QNI
G
L
E
T
D
S
RG
Q
L
K
V
N
SMY
Q
T
A
Q
PH
V
YA
V
GDV
I
G
Y
P
S
LA
SA
A
YD
Q
G
R
I
AA
Q
A
L
--
VK
G
E
A
TA
H
LI
--
ED
IP
T
G
IYT
I
PE
ISS
VG
K
TE
QQ
LT
A
M
KV
P
YE
V
G
R
AQ
F
K
HL
A
RA
Q
I
V
G
MNV
G
TL
K
I
L
F
HR
E
T
K
EIL
G
IHCF
G
ER
A
A
E
I
I
H
IG
Q
AIM
E
Q
KGG
G
N
T
I
E
YFV
N
T
TFNY
PT
M
A
E
AYR
V
AA
fig|656408.3.peg.4454
Escherichia coli H591 (10-458/466)
I
VIGSGP
G
G
E
G
AA
M
G
L
V
K
QG
A
RV
A
V
I
------
ERY
Q
N
V
GG
G
C
THW
G
T
IPSKAL
R
HA
V
SR
I
I
E
FNQN
P
L
-
YS
DHSRL
L
RS
S
F
A
D
IL
NH
A
D
N
VINQ
Q
-
T
R
M
RQ
G
FY
ER
N
H
-
CEI
L
Q
G
N
ARF
V
D
E
H
----
TL
A
L
D
C
P
DG
S
VE
TL
T
AEK
F
VIA
C
GSRP
Y
--
HPT
D
V
DFT
H
PRI
Y
DS
D
S
I
L
S
M
HH
E
P
R
HV
L
I
Y
GAGVIG
C
E
Y
A
S
I
F
RG
MDV
KVDL
I
NT
R
D
RL
L
AF
LD
QE
M
S
DS
L
SYH
F
W
N
SG
VV
I
R
H
N
E
E
Y
E
KI
E
GC
D
---
DGV
I
M
H
L
KS
GKK
--
-
-
--
-
L
KA
D
C
LL
Y
A
N
GR
TG
NT
DS
L
A
L
QNI
G
L
E
T
D
S
RG
Q
L
K
V
N
SMY
Q
T
A
Q
PH
V
YA
V
GDV
I
G
Y
P
S
LA
SA
A
YD
Q
G
R
I
AA
Q
A
L
--
VK
G
E
A
TA
H
LI
--
ED
IP
T
G
IYT
I
PE
ISS
VG
K
TE
QQ
LT
A
M
KV
P
YE
V
G
R
AQ
F
K
HL
A
RA
Q
I
V
G
MNV
G
TL
K
I
L
F
HR
E
T
K
EIL
G
IHCF
G
ER
A
A
E
I
I
H
IG
Q
AIM
E
Q
KGG
G
N
T
I
E
YFV
N
T
TFNY
PT
M
A
E
AYR
V
AA
fig|656414.3.peg.4507
Escherichia coli H736 (10-458/466)
I
VIGSGP
G
G
E
G
AA
M
G
L
V
K
QG
A
RV
A
V
I
------
ERY
Q
N
V
GG
G
C
THW
G
T
IPSKAL
R
HA
V
SR
I
I
E
FNQN
P
L
-
YS
DHSRL
L
RS
S
F
A
D
IL
NH
A
D
N
VINQ
Q
-
T
R
M
RQ
G
FY
ER
N
H
-
CEI
L
Q
G
N
ARF
V
D
E
H
----
TL
A
L
D
C
P
DG
S
VE
TL
T
AEK
F
VIA
C
GSRP
Y
--
HPT
D
V
DFT
H
PRI
Y
DS
D
S
I
L
S
M
HH
E
P
R
HV
L
I
Y
GAGVIG
C
E
Y
A
S
I
F
RG
MDV
KVDL
I
NT
R
D
RL
L
AF
LD
QE
M
S
DS
L
SYH
F
W
N
SG
VV
I
R
H
N
E
E
Y
E
KI
E
GC
D
---
DGV
I
M
H
L
KS
GKK
--
-
-
--
-
L
KA
D
C
LL
Y
A
N
GR
TG
NT
DS
L
A
L
QNI
G
L
E
T
D
S
RG
Q
L
K
V
N
SMY
Q
T
A
Q
PH
V
YA
V
GDV
I
G
Y
P
S
LA
SA
A
YD
Q
G
R
I
AA
Q
A
L
--
VK
G
E
A
TA
H
LI
--
ED
IP
T
G
IYT
I
PE
ISS
VG
K
TE
QQ
LT
A
M
KV
P
YE
V
G
R
AQ
F
K
HL
A
RA
Q
I
V
G
MNV
G
TL
K
I
L
F
HR
E
T
K
EIL
G
IHCF
G
ER
A
A
E
I
I
H
IG
Q
AIM
E
Q
KGG
G
N
T
I
E
YFV
N
T
TFNY
PT
M
A
E
AYR
V
AA
fig|585034.4.peg.4069
Escherichia coli IAI1 (10-458/466)
I
VIGSGP
G
G
E
G
AA
M
G
L
V
K
QG
A
RV
A
V
I
------
ERY
Q
N
V
GG
G
C
THW
G
T
IPSKAL
R
HA
V
SR
I
I
E
FNQN
P
L
-
YS
DHSRL
L
RS
S
F
A
D
IL
NH
A
D
N
VINQ
Q
-
T
R
M
RQ
G
FY
ER
N
H
-
CEI
L
Q
G
N
ARF
V
D
E
H
----
TL
A
L
D
C
P
DG
S
VE
TL
T
AEK
F
VIA
C
GSRP
Y
--
HPT
D
V
DFT
H
PRI
Y
DS
D
S
I
L
S
M
HH
E
P
R
HV
L
I
Y
GAGVIG
C
E
Y
A
S
I
F
RG
MDV
KVDL
I
NT
R
D
RL
L
AF
LD
QE
M
S
DS
L
SYH
F
W
N
SG
VV
I
R
H
N
E
E
Y
E
KI
E
GC
D
---
DGV
I
M
H
L
KS
GKK
--
-
-
--
-
L
KA
D
C
LL
Y
A
N
GR
TG
NT
DS
L
A
L
QNI
G
L
E
T
D
S
RG
Q
L
K
V
N
SMY
Q
T
A
Q
PH
V
YA
V
GDV
I
G
Y
P
S
LA
SA
A
YD
Q
G
R
I
AA
Q
A
L
--
VK
G
E
A
TA
H
LI
--
ED
IP
T
G
IYT
I
PE
ISS
VG
K
TE
QQ
LT
A
M
KV
P
YE
V
G
R
AQ
F
K
HL
A
RA
Q
I
V
G
MNV
G
TL
K
I
L
F
HR
E
T
K
EIL
G
IHCF
G
ER
A
A
E
I
I
H
IG
Q
AIM
E
Q
KGG
G
N
T
I
E
YFV
N
T
TFNY
PT
M
A
E
AYR
V
AA
fig|585034.5.peg.4065
Escherichia coli IAI1 (10-458/466)
I
VIGSGP
G
G
E
G
AA
M
G
L
V
K
QG
A
RV
A
V
I
------
ERY
Q
N
V
GG
G
C
THW
G
T
IPSKAL
R
HA
V
SR
I
I
E
FNQN
P
L
-
YS
DHSRL
L
RS
S
F
A
D
IL
NH
A
D
N
VINQ
Q
-
T
R
M
RQ
G
FY
ER
N
H
-
CEI
L
Q
G
N
ARF
V
D
E
H
----
TL
A
L
D
C
P
DG
S
VE
TL
T
AEK
F
VIA
C
GSRP
Y
--
HPT
D
V
DFT
H
PRI
Y
DS
D
S
I
L
S
M
HH
E
P
R
HV
L
I
Y
GAGVIG
C
E
Y
A
S
I
F
RG
MDV
KVDL
I
NT
R
D
RL
L
AF
LD
QE
M
S
DS
L
SYH
F
W
N
SG
VV
I
R
H
N
E
E
Y
E
KI
E
GC
D
---
DGV
I
M
H
L
KS
GKK
--
-
-
--
-
L
KA
D
C
LL
Y
A
N
GR
TG
NT
DS
L
A
L
QNI
G
L
E
T
D
S
RG
Q
L
K
V
N
SMY
Q
T
A
Q
PH
V
YA
V
GDV
I
G
Y
P
S
LA
SA
A
YD
Q
G
R
I
AA
Q
A
L
--
VK
G
E
A
TA
H
LI
--
ED
IP
T
G
IYT
I
PE
ISS
VG
K
TE
QQ
LT
A
M
KV
P
YE
V
G
R
AQ
F
K
HL
A
RA
Q
I
V
G
MNV
G
TL
K
I
L
F
HR
E
T
K
EIL
G
IHCF
G
ER
A
A
E
I
I
H
IG
Q
AIM
E
Q
KGG
G
N
T
I
E
YFV
N
T
TFNY
PT
M
A
E
AYR
V
AA
fig|585057.4.peg.3133
Escherichia coli IAI39 (10-458/466)
I
VIGSGP
G
G
E
G
AA
M
G
L
V
K
QG
A
RV
A
V
I
------
ERY
Q
N
V
GG
G
C
THW
G
T
IPSKAL
R
HA
V
SR
I
I
E
FNQN
P
L
-
YS
DHSRL
L
RS
S
F
A
D
IL
NH
A
D
N
VINQ
Q
-
T
R
M
RQ
G
FY
ER
N
H
-
CEI
L
Q
G
N
ARF
V
D
E
H
----
TL
A
L
D
C
P
DG
S
VE
TL
T
AEK
F
VIA
C
GSRP
Y
--
HPT
D
V
DFT
H
PRI
Y
DS
D
S
I
L
S
M
HH
E
P
R
HV
L
I
Y
GAGVIG
C
E
Y
A
S
I
F
RG
MDV
KVDL
I
NT
R
D
RL
L
AF
LD
QE
M
S
DS
L
SYH
F
W
N
SG
VV
I
R
H
N
E
E
Y
E
KI
E
GC
D
---
DGV
I
M
H
L
KS
GKK
--
-
-
--
-
L
KA
D
C
LL
Y
A
N
GR
TG
NT
DS
L
A
L
QNI
G
L
E
T
D
S
RG
Q
L
K
V
N
SMY
Q
T
A
Q
PH
V
YA
V
GDV
I
G
Y
P
S
LA
SA
A
YD
Q
G
R
I
AA
Q
A
L
--
VK
G
E
A
TA
H
LI
--
ED
IP
T
G
IYT
I
PE
ISS
VG
K
TE
QQ
LT
A
M
KV
P
YE
V
G
R
AQ
F
K
HL
A
RA
Q
I
V
G
MNV
G
TL
K
I
L
F
HR
E
T
K
EIL
G
IHCF
G
ER
A
A
E
I
I
H
IG
Q
AIM
E
Q
KGG
G
N
T
I
E
YFV
N
T
TFNY
PT
M
A
E
AYR
V
AA
fig|585057.6.peg.3139
Escherichia coli IAI39 (10-458/466)
I
VIGSGP
G
G
E
G
AA
M
G
L
V
K
QG
A
RV
A
V
I
------
ERY
Q
N
V
GG
G
C
THW
G
T
IPSKAL
R
HA
V
SR
I
I
E
FNQN
P
L
-
YS
DHSRL
L
RS
S
F
A
D
IL
NH
A
D
N
VINQ
Q
-
T
R
M
RQ
G
FY
ER
N
H
-
CEI
L
Q
G
N
ARF
V
D
E
H
----
TL
A
L
D
C
P
DG
S
VE
TL
T
AEK
F
VIA
C
GSRP
Y
--
HPT
D
V
DFT
H
PRI
Y
DS
D
S
I
L
S
M
HH
E
P
R
HV
L
I
Y
GAGVIG
C
E
Y
A
S
I
F
RG
MDV
KVDL
I
NT
R
D
RL
L
AF
LD
QE
M
S
DS
L
SYH
F
W
N
SG
VV
I
R
H
N
E
E
Y
E
KI
E
GC
D
---
DGV
I
M
H
L
KS
GKK
--
-
-
--
-
L
KA
D
C
LL
Y
A
N
GR
TG
NT
DS
L
A
L
QNI
G
L
E
T
D
S
RG
Q
L
K
V
N
SMY
Q
T
A
Q
PH
V
YA
V
GDV
I
G
Y
P
S
LA
SA
A
YD
Q
G
R
I
AA
Q
A
L
--
VK
G
E
A
TA
H
LI
--
ED
IP
T
G
IYT
I
PE
ISS
VG
K
TE
QQ
LT
A
M
KV
P
YE
V
G
R
AQ
F
K
HL
A
RA
Q
I
V
G
MNV
G
TL
K
I
L
F
HR
E
T
K
EIL
G
IHCF
G
ER
A
A
E
I
I
H
IG
Q
AIM
E
Q
KGG
G
N
T
I
E
YFV
N
T
TFNY
PT
M
A
E
AYR
V
AA
fig|714962.3.peg.4473
Escherichia coli IHE3034 (10-458/466)
I
VIGSGP
G
G
E
G
AA
M
G
L
V
K
QG
A
RV
A
V
I
------
ERY
Q
N
V
GG
G
C
THW
G
T
IPSKAL
R
HA
V
SR
I
I
E
FNQN
P
L
-
YS
DHSRL
L
RS
S
F
A
D
IL
NH
A
D
N
VINQ
Q
-
T
R
M
RQ
G
FY
ER
N
H
-
CEI
L
Q
G
N
ARF
V
D
E
H
----
TL
A
L
D
C
P
DG
S
VE
TL
T
AEK
F
VIA
C
GSRP
Y
--
HPT
D
V
DFT
H
PRI
Y
DS
D
S
I
L
S
M
HH
E
P
R
HV
L
I
Y
GAGVIG
C
E
Y
A
S
I
F
RG
MDV
KVDL
I
NT
R
D
RL
L
AF
LD
QE
M
S
DS
L
SYH
F
W
N
SG
VV
I
R
H
N
E
E
Y
E
KI
E
GC
D
---
DGV
I
M
H
L
KS
GKK
--
-
-
--
-
L
KA
D
C
LL
Y
A
N
GR
TG
NT
DS
L
A
L
QNI
G
L
E
T
D
S
RG
Q
L
K
V
N
SMY
Q
T
A
Q
PH
V
YA
V
GDV
I
G
Y
P
S
LA
SA
A
YD
Q
G
R
I
AA
Q
A
L
--
VK
G
E
A
TA
H
LI
--
ED
IP
T
G
IYT
I
PE
ISS
VG
K
TE
QQ
LT
A
M
KV
P
YE
V
G
R
AQ
F
K
HL
A
RA
Q
I
V
G
MNV
G
TL
K
I
L
F
HR
E
T
K
EIL
G
IHCF
G
ER
A
A
E
I
I
H
IG
Q
AIM
E
Q
KGG
G
N
T
I
E
YFV
N
T
TFNY
PT
M
A
E
AYR
V
AA
fig|595495.4.peg.4492
Escherichia coli KO11 (10-458/466)
I
VIGSGP
G
G
E
G
AA
M
G
L
V
K
QG
A
RV
A
V
I
------
ERY
Q
N
V
GG
G
C
THW
G
T
IPSKAL
R
HA
V
SR
I
I
E
FNQN
P
L
-
YS
DHSRL
L
RS
S
F
A
D
IL
NH
A
D
N
VINQ
Q
-
T
R
M
RQ
G
FY
ER
N
H
-
CEI
L
Q
G
N
ARF
V
D
E
H
----
TL
A
L
D
C
P
DG
S
VE
TL
T
AEK
F
VIA
C
GSRP
Y
--
HPT
D
V
DFT
H
PRI
Y
DS
D
S
I
L
S
M
HH
E
P
R
HV
L
I
Y
GAGVIG
C
E
Y
A
S
I
F
RG
MDV
KVDL
I
NT
R
D
RL
L
AF
LD
QE
M
S
DS
L
SYH
F
W
N
SG
VV
I
R
H
N
E
E
Y
E
KI
E
GC
D
---
DGV
I
M
H
L
KS
GKK
--
-
-
--
-
L
KA
D
C
LL
Y
A
N
GR
TG
NT
DS
L
A
L
QNI
G
L
E
T
D
S
RG
Q
L
K
V
N
SMY
Q
T
A
Q
PH
V
YA
V
GDV
I
G
Y
P
S
LA
SA
A
YD
Q
G
R
I
AA
Q
A
L
--
VK
G
E
A
TA
H
LI
--
ED
IP
T
G
IYT
I
PE
ISS
VG
K
TE
QQ
LT
A
M
KV
P
YE
V
G
R
AQ
F
K
HL
A
RA
Q
I
V
G
MNV
G
TL
K
I
L
F
HR
E
T
K
EIL
G
IHCF
G
ER
A
A
E
I
I
H
IG
Q
AIM
E
Q
KGG
G
N
T
I
E
YFV
N
T
TFNY
PT
M
A
E
AYR
V
AA
fig|656417.3.peg.4882
Escherichia coli M605 (10-458/466)
I
VIGSGP
G
G
E
G
AA
M
G
L
V
K
QG
A
RV
A
V
I
------
ERY
Q
N
V
GG
G
C
THW
G
T
IPSKAL
R
HA
V
SR
I
I
E
FNQN
P
L
-
YS
DHSRL
L
RS
S
F
A
D
IL
NH
A
D
N
VINQ
Q
-
T
R
M
RQ
G
FY
ER
N
H
-
CEI
L
Q
G
N
ARF
V
D
E
H
----
TL
A
L
D
C
P
DG
S
VE
TL
T
AEK
F
VIA
C
GSRP
Y
--
HPT
D
V
DFT
H
PRI
Y
DS
D
S
I
L
S
M
HH
E
P
R
HV
L
I
Y
GAGVIG
C
E
Y
A
S
I
F
RG
MDV
KVDL
I
NT
R
D
RL
L
AF
LD
QE
M
S
DS
L
SYH
F
W
N
SG
VV
I
R
H
N
E
E
Y
E
KI
E
GC
D
---
DGV
I
M
H
L
KS
GKK
--
-
-
--
-
L
KA
D
C
LL
Y
A
N
GR
TG
NT
DS
L
A
L
QNI
G
L
E
T
D
S
RG
Q
L
K
V
N
SMY
Q
T
A
Q
PH
V
YA
V
GDV
I
G
Y
P
S
LA
SA
A
YD
Q
G
R
I
AA
Q
A
L
--
VK
G
E
A
TA
H
LI
--
ED
IP
T
G
IYT
I
PE
ISS
VG
K
TE
QQ
LT
A
M
KV
P
YE
V
G
R
AQ
F
K
HL
A
RA
Q
I
V
G
MNV
G
TL
K
I
L
F
HR
E
T
K
EIL
G
IHCF
G
ER
A
A
E
I
I
H
IG
Q
AIM
E
Q
KGG
G
N
T
I
E
YFV
N
T
TFNY
PT
M
A
E
AYR
V
AA
fig|656419.3.peg.5079
Escherichia coli M718 (10-458/466)
I
VIGSGP
G
G
E
G
AA
M
G
L
V
K
QG
A
RV
A
V
I
------
ERY
Q
N
V
GG
G
C
THW
G
T
IPSKAL
R
HA
V
SR
I
I
E
FNQN
P
L
-
YS
DHSRL
L
RS
S
F
A
D
IL
NH
A
D
N
VINQ
Q
-
T
R
M
RQ
G
FY
ER
N
H
-
CEI
L
Q
G
N
ARF
V
D
E
H
----
TL
A
L
D
C
P
DG
S
VE
TL
T
AEK
F
VIA
C
GSRP
Y
--
HPT
D
V
DFT
H
PRI
Y
DS
D
S
I
L
S
M
HH
E
P
R
HV
L
I
Y
GAGVIG
C
E
Y
A
S
I
F
RG
MDV
KVDL
I
NT
R
D
RL
L
AF
LD
QE
M
S
DS
L
SYH
F
W
N
SG
VV
I
R
H
N
E
E
Y
E
KI
E
GC
D
---
DGV
I
M
H
L
KS
GKK
--
-
-
--
-
L
KA
D
C
LL
Y
A
N
GR
TG
NT
DS
L
A
L
QNI
G
L
E
T
D
S
RG
Q
L
K
V
N
SMY
Q
T
A
Q
PH
V
YA
V
GDV
I
G
Y
P
S
LA
SA
A
YD
Q
G
R
I
AA
Q
A
L
--
VK
G
E
A
TA
H
LI
--
ED
IP
T
G
IYT
I
PE
ISS
VG
K
TE
QQ
LT
A
M
KV
P
YE
V
G
R
AQ
F
K
HL
A
RA
Q
I
V
G
MNV
G
TL
K
I
L
F
HR
E
T
K
EIL
G
IHCF
G
ER
A
A
E
I
I
H
IG
Q
AIM
E
Q
KGG
G
N
T
I
E
YFV
N
T
TFNY
PT
M
A
E
AYR
V
AA
fig|679207.4.peg.4326
Escherichia coli MS 107-1 (10-458/466)
I
VIGSGP
G
G
E
G
AA
M
G
L
V
K
QG
A
RV
A
V
I
------
ERY
Q
N
V
GG
G
C
THW
G
T
IPSKAL
R
HA
V
SR
I
I
E
FNQN
P
L
-
YS
DHSRL
L
RS
S
F
A
D
IL
NH
A
D
N
VINQ
Q
-
T
R
M
RQ
G
FY
ER
N
H
-
CEI
L
Q
G
N
ARF
V
D
E
H
----
TL
A
L
D
C
P
DG
S
VE
TL
T
AEK
F
VIA
C
GSRP
Y
--
HPT
D
V
DFT
H
PRI
Y
DS
D
S
I
L
S
M
HH
E
P
R
HV
L
I
Y
GAGVIG
C
E
Y
A
S
I
F
RG
MDV
KVDL
I
NT
R
D
RL
L
AF
LD
QE
M
S
DS
L
SYH
F
W
N
SG
VV
I
R
H
N
E
E
Y
E
KI
E
GC
D
---
DGV
I
M
H
L
KS
GKK
--
-
-
--
-
L
KA
D
C
LL
Y
A
N
GR
TG
NT
DS
L
A
L
QNI
G
L
E
T
D
S
RG
Q
L
K
V
N
SMY
Q
T
A
Q
PH
V
YA
V
GDV
I
G
Y
P
S
LA
SA
A
YD
Q
G
R
I
AA
Q
A
L
--
VK
G
E
A
TA
H
LI
--
ED
IP
T
G
IYT
I
PE
ISS
VG
K
TE
QQ
LT
A
M
KV
P
YE
V
G
R
AQ
F
K
HL
A
RA
Q
I
V
G
MNV
G
TL
K
I
L
F
HR
E
T
K
EIL
G
IHCF
G
ER
A
A
E
I
I
H
IG
Q
AIM
E
Q
KGG
G
N
T
I
E
YFV
N
T
TFNY
PT
M
A
E
AYR
V
AA
fig|749537.3.peg.798
Escherichia coli MS 115-1 (10-458/466)
I
VIGSGP
G
G
E
G
AA
M
G
L
V
K
QG
A
RV
A
V
I
------
ERY
Q
N
V
GG
G
C
THW
G
T
IPSKAL
R
HA
V
SR
I
I
E
FNQN
P
L
-
YS
DHSRL
L
RS
S
F
A
D
IL
NH
A
D
N
VINQ
Q
-
T
R
M
RQ
G
FY
ER
N
H
-
CEI
L
Q
G
N
ARF
V
D
E
H
----
TL
A
L
D
C
P
DG
S
VE
TL
T
AEK
F
VIA
C
GSRP
Y
--
HPT
D
V
DFT
H
PRI
Y
DS
D
S
I
L
S
M
HH
E
P
R
HV
L
I
Y
GAGVIG
C
E
Y
A
S
I
F
RG
MDV
KVDL
I
NT
R
D
RL
L
AF
LD
QE
M
S
DS
L
SYH
F
W
N
SG
VV
I
R
H
N
E
E
Y
E
KI
E
GC
D
---
DGV
I
M
H
L
KS
GKK
--
-
-
--
-
L
KA
D
C
LL
Y
A
N
GR
TG
NT
DS
L
A
L
QNI
G
L
E
T
D
S
RG
Q
L
K
V
N
SMY
Q
T
A
Q
PH
V
YA
V
GDV
I
G
Y
P
S
LA
SA
A
YD
Q
G
R
I
AA
Q
A
L
--
VK
G
E
A
TA
H
LI
--
ED
IP
T
G
IYT
I
PE
ISS
VG
K
TE
QQ
LT
A
M
KV
P
YE
V
G
R
AQ
F
K
HL
A
RA
Q
I
V
G
MNV
G
TL
K
I
L
F
HR
E
T
K
EIL
G
IHCF
G
ER
A
A
E
I
I
H
IG
Q
AIM
E
Q
KGG
G
N
T
I
E
YFV
N
T
TFNY
PT
M
A
E
AYR
V
AA
fig|679206.4.peg.4117
Escherichia coli MS 119-7 (10-458/466)
I
VIGSGP
G
G
E
G
AA
M
G
L
V
K
QG
A
RV
A
V
I
------
ERY
Q
N
V
GG
G
C
THW
G
T
IPSKAL
R
HA
V
SR
I
I
E
FNQN
P
L
-
YS
DHSRL
L
RS
S
F
A
D
IL
NH
A
D
N
VINQ
Q
-
T
R
M
RQ
G
FY
ER
N
H
-
CEI
L
Q
G
N
ARF
V
D
E
H
----
TL
A
L
D
C
P
DG
S
VE
TL
T
AEK
F
VIA
C
GSRP
Y
--
HPT
D
V
DFT
H
PRI
Y
DS
D
S
I
L
S
M
HH
E
P
R
HV
L
I
Y
GAGVIG
C
E
Y
A
S
I
F
RG
MDV
KVDL
I
NT
R
D
RL
L
AF
LD
QE
M
S
DS
L
SYH
F
W
N
SG
VV
I
R
H
N
E
E
Y
E
KI
E
GC
D
---
DGV
I
M
H
L
KS
GKK
--
-
-
--
-
L
KA
D
C
LL
Y
A
N
GR
TG
NT
DS
L
A
L
QNI
G
L
E
T
D
S
RG
Q
L
K
V
N
SMY
Q
T
A
Q
PH
V
YA
V
GDV
I
G
Y
P
S
LA
SA
A
YD
Q
G
R
I
AA
Q
A
L
--
VK
G
E
A
TA
H
LI
--
ED
IP
T
G
IYT
I
PE
ISS
VG
K
TE
QQ
LT
A
M
KV
P
YE
V
G
R
AQ
F
K
HL
A
RA
Q
I
V
G
MNV
G
TL
K
I
L
F
HR
E
T
K
EIL
G
IHCF
G
ER
A
A
E
I
I
H
IG
Q
AIM
E
Q
KGG
G
N
T
I
E
YFV
N
T
TFNY
PT
M
A
E
AYR
V
AA
fig|679205.4.peg.5436
Escherichia coli MS 124-1 (10-458/466)
I
VIGSGP
G
G
E
G
AA
M
G
L
V
K
QG
A
RV
A
V
I
------
ERY
Q
N
V
GG
G
C
THW
G
T
IPSKAL
R
HA
V
SR
I
I
E
FNQN
P
L
-
YS
DHSRL
L
RS
S
F
A
D
IL
NH
A
D
N
VINQ
Q
-
T
R
M
RQ
G
FY
ER
N
H
-
CEI
L
Q
G
N
ARF
V
D
E
H
----
TL
A
L
D
C
P
DG
S
VE
TL
T
AEK
F
VIA
C
GSRP
Y
--
HPT
D
V
DFT
H
PRI
Y
DS
D
S
I
L
S
M
HH
E
P
R
HV
L
I
Y
GAGVIG
C
E
Y
A
S
I
F
RG
MDV
KVDL
I
NT
R
D
RL
L
AF
LD
QE
M
S
DS
L
SYH
F
W
N
SG
VV
I
R
H
N
E
E
Y
E
KI
E
GC
D
---
DGV
I
M
H
L
KS
GKK
--
-
-
--
-
L
KA
D
C
LL
Y
A
N
GR
TG
NT
DS
L
A
L
QNI
G
L
E
T
D
S
RG
Q
L
K
V
N
SMY
Q
T
A
Q
PH
V
YA
V
GDV
I
G
Y
P
S
LA
SA
A
YD
Q
G
R
I
AA
Q
A
L
--
VK
G
E
A
TA
H
LI
--
ED
IP
T
G
IYT
I
PE
ISS
VG
K
TE
QQ
LT
A
M
KV
P
YE
V
G
R
AQ
F
K
HL
A
RA
Q
I
V
G
MNV
G
TL
K
I
L
F
HR
E
T
K
EIL
G
IHCF
G
ER
A
A
E
I
I
H
IG
Q
AIM
E
Q
KGG
G
N
T
I
E
YFV
N
T
TFNY
PT
M
A
E
AYR
V
AA
fig|679204.3.peg.4226
Escherichia coli MS 145-7 (10-458/466)
I
VIGSGP
G
G
E
G
AA
M
G
L
V
K
QG
A
RV
A
V
I
------
ERY
Q
N
V
GG
G
C
THW
G
T
IPSKAL
R
HA
V
SR
I
I
E
FNQN
P
L
-
YS
DHSRL
L
RS
S
F
A
D
IL
NH
A
D
N
VINQ
Q
-
T
R
M
RQ
G
FY
ER
N
H
-
CEI
L
Q
G
N
ARF
V
D
E
H
----
TL
A
L
D
C
P
DG
S
VE
TL
T
AEK
F
VIA
C
GSRP
Y
--
HPT
D
V
DFT
H
PRI
Y
DS
D
S
I
L
S
M
HH
E
P
R
HV
L
I
Y
GAGVIG
C
E
Y
A
S
I
F
RG
MDV
KVDL
I
NT
R
D
RL
L
AF
LD
QE
M
S
DS
L
SYH
F
W
N
SG
VV
I
R
H
N
E
E
Y
E
KI
E
GC
D
---
DGV
I
M
H
L
KS
GKK
--
-
-
--
-
L
KA
D
C
LL
Y
A
N
GR
TG
NT
DS
L
A
L
QNI
G
L
E
T
D
S
RG
Q
L
K
V
N
SMY
Q
T
A
Q
PH
V
YA
V
GDV
I
G
Y
P
S
LA
SA
A
YD
Q
G
R
I
AA
Q
A
L
--
VK
G
E
A
TA
H
LI
--
ED
IP
T
G
IYT
I
PE
ISS
VG
K
TE
QQ
LT
A
M
KV
P
YE
V
G
R
AQ
F
K
HL
A
RA
Q
I
V
G
MNV
G
TL
K
I
L
F
HR
E
T
K
EIL
G
IHCF
G
ER
A
A
E
I
I
H
IG
Q
AIM
E
Q
KGG
G
N
T
I
E
YFV
N
T
TFNY
PT
M
A
E
AYR
V
AA
fig|749545.3.peg.4008
Escherichia coli MS 182-1 (10-458/466)
I
VIGSGP
G
G
E
G
AA
M
G
L
V
K
QG
A
RV
A
V
I
------
ERY
Q
N
V
GG
G
C
THW
G
T
IPSKAL
R
HA
V
SR
I
I
E
FNQN
P
L
-
YS
DHSRL
L
RS
S
F
A
D
IL
NH
A
D
N
VINQ
Q
-
T
R
M
RQ
G
FY
ER
N
H
-
CEI
L
Q
G
N
ARF
V
D
E
H
----
TL
A
L
D
C
P
DG
S
VE
TL
T
AEK
F
VIA
C
GSRP
Y
--
HPT
D
V
DFT
H
PRI
Y
DS
D
S
I
L
S
M
HH
E
P
R
HV
L
I
Y
GAGVIG
C
E
Y
A
S
I
F
RG
MDV
KVDL
I
NT
R
D
RL
L
AF
LD
QE
M
S
DS
L
SYH
F
W
N
SG
VV
I
R
H
N
E
E
Y
E
KI
E
GC
D
---
DGV
I
M
H
L
KS
GKK
--
-
-
--
-
L
KA
D
C
LL
Y
A
N
GR
TG
NT
DS
L
A
L
QNI
G
L
E
T
D
S
RG
Q
L
K
V
N
SMY
Q
T
A
Q
PH
V
YA
V
GDV
I
G
Y
P
S
LA
SA
A
YD
Q
G
R
I
AA
Q
A
L
--
VK
G
E
A
TA
H
LI
--
ED
IP
T
G
IYT
I
PE
ISS
VG
K
TE
QQ
LT
A
M
KV
P
YE
V
G
R
AQ
F
K
HL
A
RA
Q
I
V
G
MNV
G
TL
K
I
L
F
HR
E
T
K
EIL
G
IHCF
G
ER
A
A
E
I
I
H
IG
Q
AIM
E
Q
KGG
G
N
T
I
E
YFV
N
T
TFNY
PT
M
A
E
AYR
V
AA
fig|749549.3.peg.766
Escherichia coli MS 198-1 (10-458/466)
I
VIGSGP
G
G
E
G
AA
M
G
L
V
K
QG
A
RV
A
V
I
------
ERY
Q
N
V
GG
G
C
THW
G
T
IPSKAL
R
HA
V
SR
I
I
E
FNQN
P
L
-
YS
DHSRL
L
RS
S
F
A
D
IL
NH
A
D
N
VINQ
Q
-
T
R
M
RQ
G
FY
ER
N
H
-
CEI
L
Q
G
N
ARF
V
D
E
H
----
TL
A
L
D
C
P
DG
S
VE
TL
T
AEK
F
VIA
C
GSRP
Y
--
HPT
D
V
DFT
H
PRI
Y
DS
D
S
I
L
S
M
HH
E
P
R
HV
L
I
Y
GAGVIG
C
E
Y
A
S
I
F
RG
MDV
KVDL
I
NT
R
D
RL
L
AF
LD
QE
M
S
DS
L
SYH
F
W
N
SG
VV
I
R
H
N
E
E
Y
E
KI
E
GC
D
---
DGV
I
M
H
L
KS
GKK
--
-
-
--
-
L
KA
D
C
LL
Y
A
N
GR
TG
NT
DS
L
A
L
QNI
G
L
E
T
D
S
RG
Q
L
K
V
N
SMY
Q
T
A
Q
PH
V
YA
V
GDV
I
G
Y
P
S
LA
SA
A
YD
Q
G
R
I
AA
Q
A
L
--
VK
G
E
A
TA
H
LI
--
ED
IP
T
G
IYT
I
PE
ISS
VG
K
TE
QQ
LT
A
M
KV
P
YE
V
G
R
AQ
F
K
HL
A
RA
Q
I
V
G
MNV
G
TL
K
I
L
F
HR
E
T
K
EIL
G
IHCF
G
ER
A
A
E
I
I
H
IG
Q
AIM
E
Q
KGG
G
N
T
I
E
YFV
N
T
TFNY
PT
M
A
E
AYR
V
AA
fig|749550.3.peg.2728
Escherichia coli MS 200-1 (10-458/466)
I
VIGSGP
G
G
E
G
AA
M
G
L
V
K
QG
A
RV
A
V
I
------
ERY
Q
N
V
GG
G
C
THW
G
T
IPSKAL
R
HA
V
SR
I
I
E
FNQN
P
L
-
YS
DHSRL
L
RS
S
F
A
D
IL
NH
A
D
N
VINQ
Q
-
T
R
M
RQ
G
FY
ER
N
H
-
CEI
L
Q
G
N
ARF
V
D
E
H
----
TL
A
L
D
C
P
DG
S
VE
TL
T
AEK
F
VIA
C
GSRP
Y
--
HPT
D
V
DFT
H
PRI
Y
DS
D
S
I
L
S
M
HH
E
P
R
HV
L
I
Y
GAGVIG
C
E
Y
A
S
I
F
RG
MDV
KVDL
I
NT
R
D
RL
L
AF
LD
QE
M
S
DS
L
SYH
F
W
N
SG
VV
I
R
H
N
E
E
Y
E
KI
E
GC
D
---
DGV
I
M
H
L
KS
GKK
--
-
-
--
-
L
KA
D
C
LL
Y
A
N
GR
TG
NT
DS
L
A
L
QNI
G
L
E
T
D
S
RG
Q
L
K
V
N
SMY
Q
T
A
Q
PH
V
YA
V
GDV
I
G
Y
P
S
LA
SA
A
YD
Q
G
R
I
AA
Q
A
L
--
VK
G
E
A
TA
H
LI
--
ED
IP
T
G
IYT
I
PE
ISS
VG
K
TE
QQ
LT
T
M
KV
P
YE
V
G
R
AQ
F
K
HL
A
RA
Q
I
V
G
MNV
G
TL
K
I
L
F
HR
E
T
K
EIL
G
IHCF
G
ER
A
A
E
I
I
H
IG
Q
AIM
E
Q
KGG
G
N
T
I
E
YFV
N
T
TFNY
PT
M
A
E
AYR
V
AA
fig|749527.3.peg.1959
Escherichia coli MS 21-1 (10-458/466)
I
VIGSGP
G
G
E
G
AA
M
G
L
V
K
QG
A
RV
A
V
I
------
ERY
Q
N
V
GG
G
C
THW
G
T
IPSKAL
R
HA
V
SR
I
I
E
FNQN
P
L
-
YS
DHSRL
L
RS
S
F
A
D
IL
NH
A
D
N
VINQ
Q
-
T
R
M
RQ
G
FY
ER
N
H
-
CEI
L
Q
G
N
ARF
V
D
E
H
----
TL
A
L
D
C
P
DG
S
VE
TL
T
AEK
F
VIA
C
GSRP
Y
--
HPT
D
V
DFT
H
PRI
Y
DS
D
S
I
L
S
M
HH
E
P
R
HV
L
I
Y
GAGVIG
C
E
Y
A
S
I
F
RG
MDV
KVDL
I
NT
R
D
RL
L
AF
LD
QE
M
S
DS
L
SYH
F
W
N
SG
VV
I
R
H
N
E
E
Y
E
KI
E
GC
D
---
DGV
I
M
H
L
KS
GKK
--
-
-
--
-
L
KA
D
C
LL
Y
A
N
GR
TG
NT
DS
L
A
L
QNI
G
L
E
T
D
S
RG
Q
L
K
V
N
SMY
Q
T
A
Q
PH
V
YA
V
GDV
I
G
Y
P
S
LA
SA
A
YD
Q
G
R
I
AA
Q
A
L
--
VK
G
E
A
TA
H
LI
--
ED
IP
T
G
IYT
I
PE
ISS
VG
K
TE
QQ
LT
A
M
KV
P
YE
V
G
R
AQ
F
K
HL
A
RA
Q
I
V
G
MNV
G
TL
K
I
L
F
HR
E
T
K
EIL
G
IHCF
G
ER
A
A
E
I
I
H
IG
Q
AIM
E
Q
KGG
G
N
T
I
E
YFV
N
T
TFNY
PT
M
A
E
AYR
V
AA
fig|749531.3.peg.3343
Escherichia coli MS 69-1 (10-458/466)
I
VIGSGP
G
G
E
G
AA
M
G
L
V
K
QG
A
H
V
A
V
I
------
ERY
Q
N
V
GG
G
C
THW
G
T
IPSKAL
R
HA
V
SR
I
I
E
FNQN
P
L
-
YS
DHSRL
L
RS
S
F
A
D
IL
NH
A
D
N
VINQ
Q
-
T
R
M
RQ
G
FY
ER
N
H
-
CEI
L
Q
G
N
ARF
V
D
E
H
----
TL
A
L
D
C
P
DG
S
VE
TL
T
AEK
F
VIA
C
GSRP
Y
--
HPT
D
V
DFT
H
PRI
Y
DS
D
S
I
L
S
M
HH
E
P
R
HV
L
I
Y
GAGVIG
C
E
Y
A
S
I
F
RG
MDV
KVDL
I
NT
R
D
RL
L
AF
LD
QE
M
S
DS
L
SYH
F
W
N
SG
VV
I
R
H
N
E
E
Y
E
KI
E
GC
D
---
DGV
I
M
H
L
KS
GKK
--
-
-
--
-
L
KA
D
C
LL
Y
A
N
GR
TG
NT
DS
L
A
L
QNI
G
L
E
T
D
S
RG
Q
L
K
V
N
SMY
Q
T
A
Q
PH
V
YA
V
GDV
I
G
Y
P
S
LA
SA
A
YD
Q
G
R
I
AA
Q
A
L
--
VK
G
E
A
TA
H
LI
--
ED
IP
T
G
IYT
I
PE
ISS
VG
K
TE
QQ
LT
A
M
KV
P
YE
V
G
R
AQ
F
K
HL
A
RA
Q
I
V
G
MNV
G
TL
K
I
L
F
HR
E
T
K
EIL
G
IHCF
G
ER
A
A
E
I
I
H
IG
Q
AIM
E
Q
KGG
G
N
T
I
E
YFV
N
T
TFNY
PT
M
A
E
AYR
V
AA
fig|749532.3.peg.44
Escherichia coli MS 78-1 (10-458/466)
I
VIGSGP
G
G
E
G
AA
M
G
L
V
K
QG
A
RV
A
V
I
------
ERY
Q
N
V
GG
G
C
THW
G
T
IPSKAL
R
HA
V
SR
I
I
E
FNQN
P
L
-
YS
DHSRL
L
RS
S
F
A
D
IL
NH
A
D
N
VINQ
Q
-
T
R
M
RQ
G
FY
ER
N
H
-
CEI
L
Q
G
N
ARF
V
D
E
H
----
TL
A
L
D
C
P
DG
S
VE
TL
T
AEK
F
VIA
C
GSRP
Y
--
HPT
D
V
DFT
H
PRI
Y
DS
D
S
I
L
S
M
HH
E
P
R
HV
L
I
Y
GAGVIG
C
E
Y
A
S
I
F
RG
MDV
KVDL
I
NT
R
D
RL
L
AF
LD
QE
M
S
DS
L
SYH
F
W
N
SG
VV
I
R
H
N
E
E
Y
E
KI
E
GC
D
---
DGV
I
M
H
L
KS
GKK
--
-
-
--
-
L
KA
D
C
LL
Y
A
N
GR
TG
NT
DS
L
A
L
QNI
G
L
E
T
D
S
RG
Q
L
K
V
N
SMY
Q
T
A
Q
PH
V
YA
V
GDV
I
G
Y
P
S
LA
SA
A
YD
Q
G
R
I
AA
Q
A
L
--
VK
G
E
A
TA
H
LI
--
ED
IP
T
G
IYT
I
PE
ISS
VG
K
TE
QQ
LT
A
M
KV
P
YE
V
G
R
AQ
F
K
HL
A
RA
Q
I
V
G
MNV
G
TL
K
I
L
F
HR
E
T
K
EIL
G
IHCF
G
ER
A
A
E
I
I
H
IG
Q
AIM
E
Q
KGG
G
N
T
I
E
YFV
N
T
TFNY
PT
M
A
E
AYR
V
AA
fig|749533.3.peg.723
Escherichia coli MS 84-1 (10-458/466)
I
VIGSGP
G
G
E
G
AA
M
G
L
V
K
QG
A
RV
A
V
I
------
ERY
Q
N
V
GG
G
C
THW
G
T
IPSKAL
R
HA
V
SR
I
I
E
FNQN
P
L
-
YS
DHSRL
L
RS
S
F
A
D
IL
NH
A
D
N
VINQ
Q
-
T
R
M
RQ
G
FY
ER
N
H
-
CEI
L
Q
G
N
ARF
V
D
E
H
----
TL
A
L
D
C
P
DG
S
VE
TL
T
AEK
F
VIA
C
GSRP
Y
--
HPT
D
V
DFT
H
PRI
Y
DS
D
S
I
L
S
M
HH
E
P
R
HV
L
I
Y
GAGVIG
C
E
Y
A
S
I
F
RG
MDV
KVDL
I
NT
R
D
RL
L
AF
LD
QE
M
S
DS
L
SYH
F
W
N
SG
VV
I
R
H
N
E
E
Y
E
KI
E
GC
D
---
DGV
I
M
H
L
KS
GKK
--
-
-
--
-
L
KA
D
C
LL
Y
A
N
GR
TG
NT
DS
L
A
L
QNI
G
L
E
T
D
S
RG
Q
L
K
V
N
SMY
Q
T
A
Q
PH
V
YA
V
GDV
I
G
Y
P
S
LA
SA
A
YD
Q
G
R
I
AA
Q
A
L
--
VK
G
E
A
TA
H
LI
--
ED
IP
T
G
IYT
I
PE
ISS
VG
K
TE
QQ
LT
A
M
KV
P
YE
V
G
R
AQ
F
K
HL
A
RA
Q
I
V
G
MNV
G
TL
K
I
L
F
HR
E
T
K
EIL
G
IHCF
G
ER
A
A
E
I
I
H
IG
Q
AIM
E
Q
KGG
G
N
T
I
E
YFV
N
T
TFNY
PT
M
A
E
AYR
V
AA
fig|585395.4.peg.4946
Escherichia coli O103:H2 str. 12009 (10-458/466)
I
VIGSGP
G
G
E
G
AA
M
G
L
V
K
QG
A
RV
A
V
I
------
ERY
Q
N
V
GG
G
C
THW
G
T
IPSKAL
R
HA
V
SR
I
I
E
FNQN
P
L
-
YS
DHSRL
L
RS
S
F
A
D
IL
NH
A
D
N
VINQ
Q
-
T
R
M
RQ
G
FY
ER
N
H
-
CEI
L
Q
G
N
ARF
V
D
E
H
----
TL
A
L
D
C
P
DG
S
VE
TL
T
AEK
F
VIA
C
GSRP
Y
--
HPT
D
V
DFT
H
PRI
Y
DS
D
S
I
L
S
M
HH
E
P
R
HV
L
I
Y
GAGVIG
C
E
Y
A
S
I
F
RG
MDV
KVDL
I
NT
R
D
RL
L
AF
LD
QE
M
S
DS
L
SYH
F
W
N
SG
VV
I
R
H
N
E
E
Y
E
KI
E
GC
D
---
DGV
I
M
H
L
KS
GKK
--
-
-
--
-
L
KA
D
C
LL
Y
A
N
GR
TG
NT
DS
L
A
L
QNI
G
L
E
T
D
S
RG
Q
L
K
V
N
SMY
Q
T
A
Q
PH
V
YA
V
GDV
I
G
Y
P
S
LA
SA
A
YD
Q
G
R
I
AA
Q
A
L
--
VK
G
E
A
TA
H
LI
--
ED
IP
T
G
IYT
I
PE
ISS
VG
K
TE
QQ
LT
A
M
KV
P
YE
V
G
R
AQ
F
K
HL
A
RA
Q
I
V
G
MNV
G
TL
K
I
L
F
HR
E
T
K
EIL
G
IHCF
G
ER
A
A
E
I
I
H
IG
Q
AIM
E
Q
KGG
G
N
T
I
E
YFV
N
T
TFNY
PT
M
A
E
AYR
V
AA
fig|585396.4.peg.4965
Escherichia coli O111:H- str. 11128 (10-458/466)
I
VIGSGP
G
G
E
G
AA
M
G
L
V
K
QG
A
RV
A
V
I
------
ERY
Q
N
V
GG
G
C
THW
G
T
IPSKAL
R
HA
V
SR
I
I
E
FNQN
P
L
-
YS
DHSRL
L
RS
S
F
A
D
IL
NH
A
D
N
VINQ
Q
-
T
R
M
RQ
G
FY
ER
N
H
-
CEI
L
Q
G
N
ARF
V
D
E
H
----
TL
A
L
D
C
P
DG
S
VE
TL
T
AEK
F
VIA
C
GSRP
Y
--
HPT
D
V
DFT
H
PRI
Y
DS
D
S
I
L
S
M
HH
E
P
R
HV
L
I
Y
GAGVIG
C
E
Y
A
S
I
F
RG
MDV
KVDL
I
NT
R
D
RL
L
AF
LD
QE
M
S
DS
L
SYH
F
W
N
SG
VV
I
R
H
N
E
E
Y
E
KI
E
GC
D
---
DGV
I
M
H
L
KS
GKK
--
-
-
--
-
L
KA
D
C
LL
Y
A
N
GR
TG
NT
DS
L
A
L
QNI
G
L
E
T
D
S
RG
Q
L
K
V
N
SMY
Q
T
A
Q
PH
V
YA
V
GDV
I
G
Y
P
S
LA
SA
A
YD
Q
G
R
I
AA
Q
A
L
--
VK
G
E
A
TA
H
LI
--
ED
IP
T
G
IYT
I
PE
ISS
VG
K
TE
QQ
LT
A
M
KV
P
YE
V
G
R
AQ
F
K
HL
A
RA
Q
I
V
G
MNV
G
TL
K
I
L
F
HR
E
T
K
EIL
G
IHCF
G
ER
A
A
E
I
I
H
IG
Q
AIM
E
Q
KGG
G
N
T
I
E
YFV
N
T
TFNY
PT
M
A
E
AYR
V
AA
fig|444454.5.peg.3999
Escherichia coli O157:H7 str. EC4024 (10-458/466)
I
VIGSGP
G
G
E
G
AA
M
G
L
V
K
QG
A
RV
A
V
I
------
ERY
Q
N
V
GG
G
C
THW
G
T
IPSKAL
R
HA
V
SR
I
I
E
FNQN
P
L
-
YS
DHSRL
L
RS
S
F
A
D
IL
NH
A
D
N
VINQ
Q
-
T
R
M
RQ
G
FY
ER
N
H
-
CEI
L
Q
G
N
ARF
V
D
E
H
----
TL
A
L
D
C
P
DG
S
VE
TL
T
AEK
F
VIA
C
GSRP
Y
--
HPT
D
V
DFT
H
PRI
Y
DS
D
S
I
L
S
M
HH
E
P
R
HV
L
I
Y
GAGVIG
C
E
Y
A
S
I
F
RG
MDV
KVDL
I
NT
R
D
RL
L
AF
LD
QE
M
S
DS
L
SYH
F
W
N
SG
VV
I
R
H
N
E
E
Y
E
KI
E
GC
D
---
DGV
I
M
H
L
KS
GKK
--
-
-
--
-
L
KA
D
C
LL
Y
A
N
GR
TG
NT
DS
L
A
L
QNI
G
L
E
T
D
S
RG
Q
L
K
V
N
SMY
Q
T
A
Q
PH
V
YA
V
GDV
I
G
Y
P
S
LA
SA
A
YD
Q
G
R
I
AA
Q
A
L
--
VK
G
E
A
TA
H
LI
--
ED
IP
T
G
IYT
I
PE
ISS
VG
K
TE
QQ
LT
A
M
KV
P
YE
V
G
R
AQ
F
K
HL
A
RA
Q
I
V
G
MNV
G
TL
K
I
L
F
HR
E
T
K
EIL
G
IHCF
G
ER
A
A
E
I
I
H
IG
Q
AIM
E
Q
KGG
G
N
T
I
E
YFV
N
T
TFNY
PT
M
A
E
AYR
V
AA
fig|444449.5.peg.3453
Escherichia coli O157:H7 str. EC4042 (10-458/466)
I
VIGSGP
G
G
E
G
AA
M
G
L
V
K
QG
A
RV
A
V
I
------
ERY
Q
N
V
GG
G
C
THW
G
T
IPSKAL
R
HA
V
SR
I
I
E
FNQN
P
L
-
YS
DHSRL
L
RS
S
F
A
D
IL
NH
A
D
N
VINQ
Q
-
T
R
M
RQ
G
FY
ER
N
H
-
CEI
L
Q
G
N
ARF
V
D
E
H
----
TL
A
L
D
C
P
DG
S
VE
TL
T
AEK
F
VIA
C
GSRP
Y
--
HPT
D
V
DFT
H
PRI
Y
DS
D
S
I
L
S
M
HH
E
P
R
HV
L
I
Y
GAGVIG
C
E
Y
A
S
I
F
RG
MDV
KVDL
I
NT
R
D
RL
L
AF
LD
QE
M
S
DS
L
SYH
F
W
N
SG
VV
I
R
H
N
E
E
Y
E
KI
E
GC
D
---
DGV
I
M
H
L
KS
GKK
--
-
-
--
-
L
KA
D
C
LL
Y
A
N
GR
TG
NT
DS
L
A
L
QNI
G
L
E
T
D
S
RG
Q
L
K
V
N
SMY
Q
T
A
Q
PH
V
YA
V
GDV
I
G
Y
P
S
LA
SA
A
YD
Q
G
R
I
AA
Q
A
L
--
VK
G
E
A
TA
H
LI
--
ED
IP
T
G
IYT
I
PE
ISS
VG
K
TE
QQ
LT
A
M
KV
P
YE
V
G
R
AQ
F
K
HL
A
RA
Q
I
V
G
MNV
G
TL
K
I
L
F
HR
E
T
K
EIL
G
IHCF
G
ER
A
A
E
I
I
H
IG
Q
AIM
E
Q
KGG
G
N
T
I
E
YFV
N
T
TFNY
PT
M
A
E
AYR
V
AA
fig|444448.5.peg.2209
Escherichia coli O157:H7 str. EC4045 (10-458/466)
I
VIGSGP
G
G
E
G
AA
M
G
L
V
K
QG
A
RV
A
V
I
------
ERY
Q
N
V
GG
G
C
THW
G
T
IPSKAL
R
HA
V
SR
I
I
E
FNQN
P
L
-
YS
DHSRL
L
RS
S
F
A
D
IL
NH
A
D
N
VINQ
Q
-
T
R
M
RQ
G
FY
ER
N
H
-
CEI
L
Q
G
N
ARF
V
D
E
H
----
TL
A
L
D
C
P
DG
S
VE
TL
T
AEK
F
VIA
C
GSRP
Y
--
HPT
D
V
DFT
H
PRI
Y
DS
D
S
I
L
S
M
HH
E
P
R
HV
L
I
Y
GAGVIG
C
E
Y
A
S
I
F
RG
MDV
KVDL
I
NT
R
D
RL
L
AF
LD
QE
M
S
DS
L
SYH
F
W
N
SG
VV
I
R
H
N
E
E
Y
E
KI
E
GC
D
---
DGV
I
M
H
L
KS
GKK
--
-
-
--
-
L
KA
D
C
LL
Y
A
N
GR
TG
NT
DS
L
A
L
QNI
G
L
E
T
D
S
RG
Q
L
K
V
N
SMY
Q
T
A
Q
PH
V
YA
V
GDV
I
G
Y
P
S
LA
SA
A
YD
Q
G
R
I
AA
Q
A
L
--
VK
G
E
A
TA
H
LI
--
ED
IP
T
G
IYT
I
PE
ISS
VG
K
TE
QQ
LT
A
M
KV
P
YE
V
G
R
AQ
F
K
HL
A
RA
Q
I
V
G
MNV
G
TL
K
I
L
F
HR
E
T
K
EIL
G
IHCF
G
ER
A
A
E
I
I
H
IG
Q
AIM
E
Q
KGG
G
N
T
I
E
YFV
N
T
TFNY
PT
M
A
E
AYR
V
AA
fig|444453.5.peg.2351
Escherichia coli O157:H7 str. EC4076 (10-458/466)
I
VIGSGP
G
G
E
G
AA
M
G
L
V
K
QG
A
RV
A
V
I
------
ERY
Q
N
V
GG
G
C
THW
G
T
IPSKAL
R
HA
V
SR
I
I
E
FNQN
P
L
-
YS
DHSRL
L
RS
S
F
A
D
IL
NH
A
D
N
VINQ
Q
-
T
R
M
RQ
G
FY
ER
N
H
-
CEI
L
Q
G
N
ARF
V
D
E
H
----
TL
A
L
D
C
P
DG
S
VE
TL
T
AEK
F
VIA
C
GSRP
Y
--
HPT
D
V
DFT
H
PRI
Y
DS
D
S
I
L
S
M
HH
E
P
R
HV
L
I
Y
GAGVIG
C
E
Y
A
S
I
F
RG
MDV
KVDL
I
NT
R
D
RL
L
AF
LD
QE
M
S
DS
L
SYH
F
W
N
SG
VV
I
R
H
N
E
E
Y
E
KI
E
GC
D
---
DGV
I
M
H
L
KS
GKK
--
-
-
--
-
L
KA
D
C
LL
Y
A
N
GR
TG
NT
DS
L
A
L
QNI
G
L
E
T
D
S
RG
Q
L
K
V
N
SMY
Q
T
A
Q
PH
V
YA
V
GDV
I
G
Y
P
S
LA
SA
A
YD
Q
G
R
I
AA
Q
A
L
--
VK
G
E
A
TA
H
LI
--
ED
IP
T
G
IYT
I
PE
ISS
VG
K
TE
QQ
LT
A
M
KV
P
YE
V
G
R
AQ
F
K
HL
A
RA
Q
I
V
G
MNV
G
TL
K
I
L
F
HR
E
T
K
EIL
G
IHCF
G
ER
A
A
E
I
I
H
IG
Q
AIM
E
Q
KGG
G
N
T
I
E
YFV
N
T
TFNY
PT
M
A
E
AYR
V
AA
fig|444452.5.peg.1762
Escherichia coli O157:H7 str. EC4113 (10-458/466)
I
VIGSGP
G
G
E
G
AA
M
G
L
V
K
QG
A
RV
A
V
I
------
ERY
Q
N
V
GG
G
C
THW
G
T
IPSKAL
R
HA
V
SR
I
I
E
FNQN
P
L
-
YS
DHSRL
L
RS
S
F
A
D
IL
NH
A
D
N
VINQ
Q
-
T
R
M
RQ
G
FY
ER
N
H
-
CEI
L
Q
G
N
ARF
V
D
E
H
----
TL
A
L
D
C
P
DG
S
VE
TL
T
AEK
F
VIA
C
GSRP
Y
--
HPT
D
V
DFT
H
PRI
Y
DS
D
S
I
L
S
M
HH
E
P
R
HV
L
I
Y
GAGVIG
C
E
Y
A
S
I
F
RG
MDV
KVDL
I
NT
R
D
RL
L
AF
LD
QE
M
S
DS
L
SYH
F
W
N
SG
VV
I
R
H
N
E
E
Y
E
KI
E
GC
D
---
DGV
I
M
H
L
KS
GKK
--
-
-
--
-
L
KA
D
C
LL
Y
A
N
GR
TG
NT
DS
L
A
L
QNI
G
L
E
T
D
S
RG
Q
L
K
V
N
SMY
Q
T
A
Q
PH
V
YA
V
GDV
I
G
Y
P
S
LA
SA
A
YD
Q
G
R
I
AA
Q
A
L
--
VK
G
E
A
TA
H
LI
--
ED
IP
T
G
IYT
I
PE
ISS
VG
K
TE
QQ
LT
A
M
KV
P
YE
V
G
R
AQ
F
K
HL
A
RA
Q
I
V
G
MNV
G
TL
K
I
L
F
HR
E
T
K
EIL
G
IHCF
G
ER
A
A
E
I
I
H
IG
Q
AIM
E
Q
KGG
G
N
T
I
E
YFV
N
T
TFNY
PT
M
A
E
AYR
V
AA
fig|444450.8.peg.5290
Escherichia coli O157:H7 str. EC4115 (10-458/466)
I
VIGSGP
G
G
E
G
AA
M
G
L
V
K
QG
A
RV
A
V
I
------
ERY
Q
N
V
GG
G
C
THW
G
T
IPSKAL
R
HA
V
SR
I
I
E
FNQN
P
L
-
YS
DHSRL
L
RS
S
F
A
D
IL
NH
A
D
N
VINQ
Q
-
T
R
M
RQ
G
FY
ER
N
H
-
CEI
L
Q
G
N
ARF
V
D
E
H
----
TL
A
L
D
C
P
DG
S
VE
TL
T
AEK
F
VIA
C
GSRP
Y
--
HPT
D
V
DFT
H
PRI
Y
DS
D
S
I
L
S
M
HH
E
P
R
HV
L
I
Y
GAGVIG
C
E
Y
A
S
I
F
RG
MDV
KVDL
I
NT
R
D
RL
L
AF
LD
QE
M
S
DS
L
SYH
F
W
N
SG
VV
I
R
H
N
E
E
Y
E
KI
E
GC
D
---
DGV
I
M
H
L
KS
GKK
--
-
-
--
-
L
KA
D
C
LL
Y
A
N
GR
TG
NT
DS
L
A
L
QNI
G
L
E
T
D
S
RG
Q
L
K
V
N
SMY
Q
T
A
Q
PH
V
YA
V
GDV
I
G
Y
P
S
LA
SA
A
YD
Q
G
R
I
AA
Q
A
L
--
VK
G
E
A
TA
H
LI
--
ED
IP
T
G
IYT
I
PE
ISS
VG
K
TE
QQ
LT
A
M
KV
P
YE
V
G
R
AQ
F
K
HL
A
RA
Q
I
V
G
MNV
G
TL
K
I
L
F
HR
E
T
K
EIL
G
IHCF
G
ER
A
A
E
I
I
H
IG
Q
AIM
E
Q
KGG
G
N
T
I
E
YFV
N
T
TFNY
PT
M
A
E
AYR
V
AA
fig|444451.5.peg.2808
Escherichia coli O157:H7 str. EC4196 (10-458/466)
I
VIGSGP
G
G
E
G
AA
M
G
L
V
K
QG
A
RV
A
V
I
------
ERY
Q
N
V
GG
G
C
THW
G
T
IPSKAL
R
HA
V
SR
I
I
E
FNQN
P
L
-
YS
DHSRL
L
RS
S
F
A
D
IL
NH
A
D
N
VINQ
Q
-
T
R
M
RQ
G
FY
ER
N
H
-
CEI
L
Q
G
N
ARF
V
D
E
H
----
TL
A
L
D
C
P
DG
S
VE
TL
T
AEK
F
VIA
C
GSRP
Y
--
HPT
D
V
DFT
H
PRI
Y
DS
D
S
I
L
S
M
HH
E
P
R
HV
L
I
Y
GAGVIG
C
E
Y
A
S
I
F
RG
MDV
KVDL
I
NT
R
D
RL
L
AF
LD
QE
M
S
DS
L
SYH
F
W
N
SG
VV
I
R
H
N
E
E
Y
E
KI
E
GC
D
---
DGV
I
M
H
L
KS
GKK
--
-
-
--
-
L
KA
D
C
LL
Y
A
N
GR
TG
NT
DS
L
A
L
QNI
G
L
E
T
D
S
RG
Q
L
K
V
N
SMY
Q
T
A
Q
PH
V
YA
V
GDV
I
G
Y
P
S
LA
SA
A
YD
Q
G
R
I
AA
Q
A
L
--
VK
G
E
A
TA
H
LI
--
ED
IP
T
G
IYT
I
PE
ISS
VG
K
TE
QQ
LT
A
M
KV
P
YE
V
G
R
AQ
F
K
HL
A
RA
Q
I
V
G
MNV
G
TL
K
I
L
F
HR
E
T
K
EIL
G
IHCF
G
ER
A
A
E
I
I
H
IG
Q
AIM
E
Q
KGG
G
N
T
I
E
YFV
N
T
TFNY
PT
M
A
E
AYR
V
AA
fig|444447.5.peg.2374
Escherichia coli O157:H7 str. EC4206 (10-458/466)
I
VIGSGP
G
G
E
G
AA
M
G
L
V
K
QG
A
RV
A
V
I
------
ERY
Q
N
V
GG
G
C
THW
G
T
IPSKAL
R
HA
V
SR
I
I
E
FNQN
P
L
-
YS
DHSRL
L
RS
S
F
A
D
IL
NH
A
D
N
VINQ
Q
-
T
R
M
RQ
G
FY
ER
N
H
-
CEI
L
Q
G
N
ARF
V
D
E
H
----
TL
A
L
D
C
P
DG
S
VE
TL
T
AEK
F
VIA
C
GSRP
Y
--
HPT
D
V
DFT
H
PRI
Y
DS
D
S
I
L
S
M
HH
E
P
R
HV
L
I
Y
GAGVIG
C
E
Y
A
S
I
F
RG
MDV
KVDL
I
NT
R
D
RL
L
AF
LD
QE
M
S
DS
L
SYH
F
W
N
SG
VV
I
R
H
N
E
E
Y
E
KI
E
GC
D
---
DGV
I
M
H
L
KS
GKK
--
-
-
--
-
L
KA
D
C
LL
Y
A
N
GR
TG
NT
DS
L
A
L
QNI
G
L
E
T
D
S
RG
Q
L
K
V
N
SMY
Q
T
A
Q
PH
V
YA
V
GDV
I
G
Y
P
S
LA
SA
A
YD
Q
G
R
I
AA
Q
A
L
--
VK
G
E
A
TA
H
LI
--
ED
IP
T
G
IYT
I
PE
ISS
VG
K
TE
QQ
LT
A
M
KV
P
YE
V
G
R
AQ
F
K
HL
A
RA
Q
I
V
G
MNV
G
TL
K
I
L
F
HR
E
T
K
EIL
G
IHCF
G
ER
A
A
E
I
I
H
IG
Q
AIM
E
Q
KGG
G
N
T
I
E
YFV
N
T
TFNY
PT
M
A
E
AYR
V
AA
fig|478004.5.peg.2425
Escherichia coli O157:H7 str. EC4401 (10-458/466)
I
VIGSGP
G
G
E
G
AA
M
G
L
V
K
QG
A
RV
A
V
I
------
ERY
Q
N
V
GG
G
C
THW
G
T
IPSKAL
R
HA
V
SR
I
I
E
FNQN
P
L
-
YS
DHSRL
L
RS
S
F
A
D
IL
NH
A
D
N
VINQ
Q
-
T
R
M
RQ
G
FY
ER
N
H
-
CEI
L
Q
G
N
ARF
V
D
E
H
----
TL
A
L
D
C
P
DG
S
VE
TL
T
AEK
F
VIA
C
GSRP
Y
--
HPT
D
V
DFT
H
PRI
Y
DS
D
S
I
L
S
M
HH
E
P
R
HV
L
I
Y
GAGVIG
C
E
Y
A
S
I
F
RG
MDV
KVDL
I
NT
R
D
RL
L
AF
LD
QE
M
S
DS
L
SYH
F
W
N
SG
VV
I
R
H
N
E
E
Y
E
KI
E
GC
D
---
DGV
I
M
H
L
KS
GKK
--
-
-
--
-
L
KA
D
C
LL
Y
A
N
GR
TG
NT
DS
L
A
L
QNI
G
L
E
T
D
S
RG
Q
L
K
V
N
SMY
Q
T
A
Q
PH
V
YA
V
GDV
I
G
Y
P
S
LA
SA
A
YD
Q
G
R
I
AA
Q
A
L
--
VK
G
E
A
TA
H
LI
--
ED
IP
T
G
IYT
I
PE
ISS
VG
K
TE
QQ
LT
A
M
KV
P
YE
V
G
R
AQ
F
K
HL
A
RA
Q
I
V
G
MNV
G
TL
K
I
L
F
HR
E
T
K
EIL
G
IHCF
G
ER
A
A
E
I
I
H
IG
Q
AIM
E
Q
KGG
G
N
T
I
E
YFV
N
T
TFNY
PT
M
A
E
AYR
V
AA
fig|478007.5.peg.2191
Escherichia coli O157:H7 str. EC508 (10-458/466)
I
VIGSGP
G
G
E
G
AA
M
G
L
V
K
QG
A
RV
A
V
I
------
ERY
Q
N
V
GG
G
C
THW
G
T
IPSKAL
R
HA
V
SR
I
I
E
FNQN
P
L
-
YS
DHSRL
L
RS
S
F
A
D
IL
NH
A
D
N
VINQ
Q
-
T
R
M
RQ
G
FY
ER
N
H
-
CEI
L
Q
G
N
ARF
V
D
E
H
----
TL
A
L
D
C
P
DG
S
VE
TL
T
AEK
F
VIA
C
GSRP
Y
--
HPT
D
V
DFT
H
PRI
Y
DS
D
S
I
L
S
M
HH
E
P
R
HV
L
I
Y
GAGVIG
C
E
Y
A
S
I
F
RG
MDV
KVDL
I
NT
R
D
RL
L
AF
LD
QE
M
S
DS
L
SYH
F
W
N
SG
VV
I
R
H
N
E
E
Y
E
KI
E
GC
D
---
DGV
I
M
H
L
KS
GKK
--
-
-
--
-
L
KA
D
C
LL
Y
A
N
GR
TG
NT
DS
L
A
L
QNI
G
L
E
T
D
S
RG
Q
L
K
V
N
SMY
Q
T
A
Q
PH
V
YA
V
GDV
I
G
Y
P
S
LA
SA
A
YD
Q
G
R
I
AA
Q
A
L
--
VK
G
E
A
TA
H
LI
--
ED
IP
T
G
IYT
I
PE
ISS
VG
K
TE
QQ
LT
A
M
KV
P
YE
V
G
R
AQ
F
K
HL
A
RA
Q
I
V
G
MNV
G
TL
K
I
L
F
HR
E
T
K
EIL
G
IHCF
G
ER
A
A
E
I
I
H
IG
Q
AIM
E
Q
KGG
G
N
T
I
E
YFV
N
T
TFNY
PT
M
A
E
AYR
V
AA
fig|478008.5.peg.2098
Escherichia coli O157:H7 str. EC869 (10-458/466)
I
VIGSGP
G
G
E
G
AA
M
G
L
V
K
QG
A
RV
A
V
I
------
ERY
Q
N
V
GG
G
C
THW
G
T
IPSKAL
R
HA
V
SR
I
I
E
FNQN
P
L
-
YS
DHSRL
L
RS
S
F
A
D
IL
NH
A
D
N
VINQ
Q
-
T
R
M
RQ
G
FY
ER
N
H
-
CEI
L
Q
G
N
ARF
V
D
E
H
----
TL
A
L
D
C
P
DG
S
VE
TL
T
AEK
F
VIA
C
GSRP
Y
--
HPT
D
V
DFT
H
PRI
Y
DS
D
S
I
L
S
M
HH
E
P
R
HV
L
I
Y
GAGVIG
C
E
Y
A
S
I
F
RG
MDV
KVDL
I
NT
R
D
RL
L
AF
LD
QE
M
S
DS
L
SYH
F
W
N
SG
VV
I
R
H
N
E
E
Y
E
KI
E
GC
D
---
DGV
I
M
H
L
KS
GKK
--
-
-
--
-
L
KA
D
C
LL
Y
A
N
GR
TG
NT
DS
L
A
L
QNI
G
L
E
T
D
S
RG
Q
L
K
V
N
SMY
Q
T
A
Q
PH
V
YA
V
GDV
I
G
Y
P
S
LA
SA
A
YD
Q
G
R
I
AA
Q
A
L
--
VK
G
E
A
TA
H
LI
--
ED
IP
T
G
IYT
I
PE
ISS
VG
K
TE
QQ
LT
A
M
KV
P
YE
V
G
R
AQ
F
K
HL
A
RA
Q
I
V
G
MNV
G
TL
K
I
L
F
HR
E
T
K
EIL
G
IHCF
G
ER
A
A
E
I
I
H
IG
Q
AIM
E
Q
KGG
G
N
T
I
E
YFV
N
T
TFNY
PT
M
A
E
AYR
V
AA
fig|637388.3.peg.3504
Escherichia coli O157:H7 str. FRIK2000 (10-458/466)
I
VIGSGP
G
G
E
G
AA
M
G
L
V
K
QG
A
RV
A
V
I
------
ERY
Q
N
V
GG
G
C
THW
G
T
IPSKAL
R
HA
V
SR
I
I
E
FNQN
P
L
-
YS
DHSRL
L
RS
S
F
A
D
IL
NH
A
D
N
VINQ
Q
-
T
R
M
RQ
G
FY
ER
N
H
-
CEI
L
Q
G
N
ARF
V
D
E
H
----
TL
A
L
D
C
P
DG
S
VE
TL
T
AEK
F
VIA
C
GSRP
Y
--
HPT
D
V
DFT
H
PRI
Y
DS
D
S
I
L
S
M
HH
E
P
R
HV
L
I
Y
GAGVIG
C
E
Y
A
S
I
F
RG
MDV
KVDL
I
NT
R
D
RL
L
AF
LD
QE
M
S
DS
L
SYH
F
W
N
SG
VV
I
R
H
N
E
E
Y
E
KI
E
GC
D
---
DGV
I
M
H
L
KS
GKK
--
-
-
--
-
L
KA
D
C
LL
Y
A
N
GR
TG
NT
DS
L
A
L
QNI
G
L
E
T
D
S
RG
Q
L
K
V
N
SMY
Q
T
A
Q
PH
V
YA
V
GDV
I
G
Y
P
S
LA
SA
A
YD
Q
G
R
I
AA
Q
A
L
--
VK
G
E
A
TA
H
LI
--
ED
IP
T
G
IYT
I
PE
ISS
VG
K
TE
QQ
LT
A
M
KV
P
YE
V
G
R
AQ
F
K
HL
A
RA
Q
I
V
G
MNV
G
TL
K
I
L
F
HR
E
T
K
EIL
G
IHCF
G
ER
A
A
E
I
I
H
IG
Q
AIM
E
Q
KGG
G
N
T
I
E
YFV
N
T
TFNY
PT
M
A
E
AYR
V
AA
fig|570506.3.peg.2693
Escherichia coli O157:H7 str. FRIK966 (10-458/466)
I
VIGSGP
G
G
E
G
AA
M
G
L
V
K
QG
A
RV
A
V
I
------
ERY
Q
N
V
GG
G
C
THW
G
T
IPSKAL
R
HA
V
SR
I
I
E
FNQN
P
L
-
YS
DHSRL
L
RS
S
F
A
D
IL
NH
A
D
N
VINQ
Q
-
T
R
M
RQ
G
FY
ER
N
H
-
CEI
L
Q
G
N
ARF
V
D
E
H
----
TL
A
L
D
C
P
DG
S
VE
TL
T
AEK
F
VIA
C
GSRP
Y
--
HPT
D
V
DFT
H
PRI
Y
DS
D
S
I
L
S
M
HH
E
P
R
HV
L
I
Y
GAGVIG
C
E
Y
A
S
I
F
RG
MDV
KVDL
I
NT
R
D
RL
L
AF
LD
QE
M
S
DS
L
SYH
F
W
N
SG
VV
I
R
H
N
E
E
Y
E
KI
E
GC
D
---
DGV
I
M
H
L
KS
GKK
--
-
-
--
-
L
KA
D
C
LL
Y
A
N
GR
TG
NT
DS
L
A
L
QNI
G
L
E
T
D
S
RG
Q
L
K
V
N
SMY
Q
T
A
Q
PH
V
YA
V
GDV
I
G
Y
P
S
LA
SA
A
YD
Q
G
R
I
AA
Q
A
L
--
VK
G
E
A
TA
H
LI
--
ED
IP
T
G
IYT
I
PE
ISS
VG
K
TE
QQ
LT
A
M
KV
P
YE
V
G
R
AQ
F
K
HL
A
RA
Q
I
V
G
MNV
G
TL
K
I
L
F
HR
E
T
K
EIL
G
IHCF
G
ER
A
A
E
I
I
H
IG
Q
AIM
E
Q
KGG
G
N
T
I
E
YFV
N
T
TFNY
PT
M
A
E
AYR
V
AA
fig|544404.4.peg.5100
Escherichia coli O157:H7 str. TW14359 (10-458/466)
I
VIGSGP
G
G
E
G
AA
M
G
L
V
K
QG
A
RV
A
V
I
------
ERY
Q
N
V
GG
G
C
THW
G
T
IPSKAL
R
HA
V
SR
I
I
E
FNQN
P
L
-
YS
DHSRL
L
RS
S
F
A
D
IL
NH
A
D
N
VINQ
Q
-
T
R
M
RQ
G
FY
ER
N
H
-
CEI
L
Q
G
N
ARF
V
D
E
H
----
TL
A
L
D
C
P
DG
S
VE
TL
T
AEK
F
VIA
C
GSRP
Y
--
HPT
D
V
DFT
H
PRI
Y
DS
D
S
I
L
S
M
HH
E
P
R
HV
L
I
Y
GAGVIG
C
E
Y
A
S
I
F
RG
MDV
KVDL
I
NT
R
D
RL
L
AF
LD
QE
M
S
DS
L
SYH
F
W
N
SG
VV
I
R
H
N
E
E
Y
E
KI
E
GC
D
---
DGV
I
M
H
L
KS
GKK
--
-
-
--
-
L
KA
D
C
LL
Y
A
N
GR
TG
NT
DS
L
A
L
QNI
G
L
E
T
D
S
RG
Q
L
K
V
N
SMY
Q
T
A
Q
PH
V
YA
V
GDV
I
G
Y
P
S
LA
SA
A
YD
Q
G
R
I
AA
Q
A
L
--
VK
G
E
A
TA
H
LI
--
ED
IP
T
G
IYT
I
PE
ISS
VG
K
TE
QQ
LT
A
M
KV
P
YE
V
G
R
AQ
F
K
HL
A
RA
Q
I
V
G
MNV
G
TL
K
I
L
F
HR
E
T
K
EIL
G
IHCF
G
ER
A
A
E
I
I
H
IG
Q
AIM
E
Q
KGG
G
N
T
I
E
YFV
N
T
TFNY
PT
M
A
E
AYR
V
AA
fig|573235.3.peg.5232
Escherichia coli O26:H11 str. 11368 (10-458/466)
I
VIGSGP
G
G
E
G
AA
M
G
L
V
K
QG
A
RV
A
V
I
------
ERY
Q
N
V
GG
G
C
THW
G
T
IPSKAL
R
HA
V
SR
I
I
E
FNQN
P
L
-
YS
DHSRL
L
RS
S
F
A
D
IL
NH
A
D
N
VINQ
Q
-
T
R
M
RQ
G
FY
ER
N
H
-
CEI
L
Q
G
N
ARF
V
D
E
H
----
TL
A
L
D
C
P
DG
S
VE
TL
T
AEK
F
VIA
C
GSRP
Y
--
HPT
D
V
DFT
H
PRI
Y
DS
D
S
I
L
S
M
HH
E
P
R
HV
L
I
Y
GAGVIG
C
E
Y
A
S
I
F
RG
MDV
KVDL
I
NT
R
D
RL
L
AF
LD
QE
M
S
DS
L
SYH
F
W
N
SG
VV
I
R
H
N
E
E
Y
E
KI
E
GC
D
---
DGV
I
M
H
L
KS
GKK
--
-
-
--
-
L
KA
D
C
LL
Y
A
N
GR
TG
NT
DS
L
A
L
QNI
G
L
E
T
D
S
RG
Q
L
K
V
N
SMY
Q
T
A
Q
PH
V
YA
V
GDV
I
G
Y
P
S
LA
SA
A
YD
Q
G
R
I
AA
Q
A
L
--
VK
G
E
A
TA
H
LI
--
ED
IP
T
G
IYT
I
PE
ISS
VG
K
TE
QQ
LT
A
M
KV
P
YE
V
G
R
AQ
F
K
HL
A
RA
Q
I
V
G
MNV
G
TL
K
I
L
F
HR
E
T
K
EIL
G
IHCF
G
ER
A
A
E
I
I
H
IG
Q
AIM
E
Q
KGG
G
N
T
I
E
YFV
N
T
TFNY
PT
M
A
E
AYR
V
AA
fig|701177.3.peg.4783
Escherichia coli O55:H7 str. CB9615 (10-458/466)
I
VIGSGP
G
G
E
G
AA
M
G
L
V
K
QG
A
RV
A
V
I
------
ERY
Q
N
V
GG
G
C
THW
G
T
IPSKAL
R
HA
V
SR
I
I
E
FNQN
P
L
-
YS
DHSRL
L
RS
S
F
A
D
IL
NH
A
D
N
VINQ
Q
-
T
R
M
RQ
G
FY
ER
N
H
-
CEI
L
Q
G
N
ARF
V
D
E
H
----
TL
A
L
D
C
P
DG
S
VE
TL
T
AEK
F
VIA
C
GSRP
Y
--
HPT
D
V
DFT
H
PRI
Y
DS
D
S
I
L
S
M
HH
E
P
R
HV
L
I
Y
GAGVIG
C
E
Y
A
S
I
F
RG
MDV
KVDL
I
NT
R
D
RL
L
AF
LD
QE
M
S
DS
L
SYH
F
W
N
SG
VV
I
R
H
N
E
E
Y
E
KI
E
GC
D
---
DGV
I
M
H
L
KS
GKK
--
-
-
--
-
L
KA
D
C
LL
Y
A
N
GR
TG
NT
DS
L
A
L
QNI
G
L
E
T
D
S
RG
Q
L
K
V
N
SMY
Q
T
A
Q
PH
V
YA
V
GDV
I
G
Y
P
S
LA
SA
A
YD
Q
G
R
I
AA
Q
A
L
--
VK
G
E
A
TA
H
LI
--
ED
IP
T
G
IYT
I
PE
ISS
VG
K
TE
QQ
LT
A
M
KV
P
YE
V
G
R
AQ
F
K
HL
A
RA
Q
I
V
G
MNV
G
TL
K
I
L
F
HR
E
T
K
EIL
G
IHCF
G
ER
A
A
E
I
I
H
IG
Q
AIM
E
Q
KGG
G
N
T
I
E
YFV
N
T
TFNY
PT
M
A
E
AYR
V
AA
fig|585035.6.peg.4336
Escherichia coli S88 (10-458/466)
I
VIGSGP
G
G
E
G
AA
M
G
L
V
K
QG
A
RV
A
V
I
------
ERY
Q
N
V
GG
G
C
THW
G
T
IPSKAL
R
HA
V
SR
I
I
E
FNQN
P
L
-
YS
DHSRL
L
RS
S
F
A
D
IL
NH
A
D
N
VINQ
Q
-
T
R
M
RQ
G
FY
ER
N
H
-
CEI
L
Q
G
N
ARF
V
D
E
H
----
TL
A
L
D
C
P
DG
S
VE
TL
T
AEK
F
VIA
C
GSRP
Y
--
HPT
D
V
DFT
H
PRI
Y
DS
D
S
I
L
S
M
HH
E
P
R
HV
L
I
Y
GAGVIG
C
E
Y
A
S
I
F
RG
MDV
KVDL
I
NT
R
D
RL
L
AF
LD
QE
M
S
DS
L
SYH
F
W
N
SG
VV
I
R
H
N
E
E
Y
E
KI
E
GC
D
---
DGV
I
M
H
L
KS
GKK
--
-
-
--
-
L
KA
D
C
LL
Y
A
N
GR
TG
NT
DS
L
A
L
QNI
G
L
E
T
D
S
RG
Q
L
K
V
N
SMY
Q
T
A
Q
PH
V
YA
V
GDV
I
G
Y
P
S
LA
SA
A
YD
Q
G
R
I
AA
Q
A
L
--
VK
G
E
A
TA
H
LI
--
ED
IP
T
G
IYT
I
PE
ISS
VG
K
TE
QQ
LT
A
M
KV
P
YE
V
G
R
AQ
F
K
HL
A
RA
Q
I
V
G
MNV
G
TL
K
I
L
F
HR
E
T
K
EIL
G
IHCF
G
ER
A
A
E
I
I
H
IG
Q
AIM
E
Q
KGG
G
N
T
I
E
YFV
N
T
TFNY
PT
M
A
E
AYR
V
AA
fig|409438.11.peg.4436
Escherichia coli SE11 (10-458/466)
I
VIGSGP
G
G
E
G
AA
M
G
L
V
K
QG
A
RV
A
V
I
------
ERY
Q
N
V
GG
G
C
THW
G
T
IPSKAL
R
HA
V
SR
I
I
E
FNQN
P
L
-
YS
DHSRL
L
RS
S
F
A
D
IL
NH
A
D
N
VINQ
Q
-
T
R
M
RQ
G
FY
ER
N
H
-
CEI
L
Q
G
N
ARF
V
D
E
H
----
TL
A
L
D
C
P
DG
S
VE
TL
T
AEK
F
VIA
C
GSRP
Y
--
HPT
D
V
DFT
H
PRI
Y
DS
D
S
I
L
S
M
HH
E
P
R
HV
L
I
Y
GAGVIG
C
E
Y
A
S
I
F
RG
MDV
KVDL
I
NT
R
D
RL
L
AF
LD
QE
M
S
DS
L
SYH
F
W
N
SG
VV
I
R
H
N
E
E
Y
E
KI
E
GC
D
---
DGV
I
M
H
L
KS
GKK
--
-
-
--
-
L
KA
D
C
LL
Y
A
N
GR
TG
NT
DS
L
A
L
QNI
G
L
E
T
D
S
RG
Q
L
K
V
N
SMY
Q
T
A
Q
PH
V
YA
V
GDV
I
G
Y
P
S
LA
SA
A
YD
Q
G
R
I
AA
Q
A
L
--
VK
G
E
A
TA
H
LI
--
ED
IP
T
G
IYT
I
PE
ISS
VG
K
TE
QQ
LT
A
M
KV
P
YE
V
G
R
AQ
F
K
HL
A
RA
Q
I
V
G
MNV
G
TL
K
I
L
F
HR
E
T
K
EIL
G
IHCF
G
ER
A
A
E
I
I
H
IG
Q
AIM
E
Q
KGG
G
N
T
I
E
YFV
N
T
TFNY
PT
M
A
E
AYR
V
AA
fig|431946.3.peg.3979
Escherichia coli SE15 (10-458/466)
I
VIGSGP
G
G
E
G
AA
M
G
L
V
K
QG
A
RV
A
V
I
------
ERY
Q
N
V
GG
G
C
THW
G
T
IPSKAL
R
HA
V
SR
I
I
E
FNQN
P
L
-
YS
DHSRL
L
RS
S
F
A
D
IL
NH
A
D
N
VINQ
Q
-
T
R
M
RQ
G
FY
ER
N
H
-
CEI
L
Q
G
N
ARF
V
D
E
H
----
TL
A
L
D
C
P
DG
S
VE
TL
T
AEK
F
VIA
C
GSRP
Y
--
HPT
D
V
DFT
H
PRI
Y
DS
D
S
I
L
S
M
HH
E
P
R
HV
L
I
Y
GAGVIG
C
E
Y
A
S
I
F
RG
MDV
KVDL
I
NT
R
D
RL
L
AF
LD
QE
M
S
DS
L
SYH
F
W
N
SG
VV
I
R
H
N
E
E
Y
E
KI
E
GC
D
---
DGV
I
M
H
L
KS
GKK
--
-
-
--
-
L
KA
D
C
LL
Y
A
N
GR
TG
NT
DS
L
A
L
QNI
G
L
E
T
D
S
RG
Q
L
K
V
N
SMY
Q
T
A
Q
PH
V
YA
V
GDV
I
G
Y
P
S
LA
SA
A
YD
Q
G
R
I
AA
Q
A
L
--
VK
G
E
A
TA
H
LI
--
ED
IP
T
G
IYT
I
PE
ISS
VG
K
TE
QQ
LT
A
M
KV
P
YE
V
G
R
AQ
F
K
HL
A
RA
Q
I
V
G
MNV
G
TL
K
I
L
F
HR
E
T
K
EIL
G
IHCF
G
ER
A
A
E
I
I
H
IG
Q
AIM
E
Q
KGG
G
N
T
I
E
YFV
N
T
TFNY
PT
M
A
E
AYR
V
AA
fig|656437.3.peg.4458
Escherichia coli TA143 (10-458/466)
I
VIGSGP
G
G
E
G
AA
M
G
L
V
K
QG
A
RV
A
V
I
------
ERY
Q
N
V
GG
G
C
THW
G
T
IPSKAL
R
HA
V
SR
I
I
E
FNQN
P
L
-
YS
DHSRL
L
RS
S
F
A
D
IL
NH
A
D
N
VINQ
Q
-
T
R
M
RQ
G
FY
ER
N
H
-
CEI
L
Q
G
N
ARF
V
D
E
H
----
TL
A
L
D
C
P
DG
S
VE
TL
T
AEK
F
VIA
C
GSRP
Y
--
HPT
D
V
DFT
H
PRI
Y
DS
D
S
I
L
S
M
HH
E
P
R
HV
L
I
Y
GAGVIG
C
E
Y
A
S
I
F
RG
MDV
KVDL
I
NT
R
D
RL
L
AF
LD
QE
M
S
DS
L
SYH
F
W
N
SG
VV
I
R
H
N
E
E
Y
E
KI
E
GC
D
---
DGV
I
M
H
L
KS
GKK
--
-
-
--
-
L
KA
D
C
LL
Y
A
N
GR
TG
NT
DS
L
A
L
QNI
G
L
E
T
D
S
RG
Q
L
K
V
N
SMY
Q
T
A
Q
PH
V
YA
V
GDV
I
G
Y
P
S
LA
SA
A
YD
Q
G
R
I
AA
Q
A
L
--
VK
G
E
A
TA
H
LI
--
ED
IP
T
G
IYT
I
PE
ISS
VG
K
TE
QQ
LT
A
M
KV
P
YE
V
G
R
AQ
F
K
HL
A
RA
Q
I
V
G
MNV
G
TL
K
I
L
F
HR
E
T
K
EIL
G
IHCF
G
ER
A
A
E
I
I
H
IG
Q
AIM
E
Q
KGG
G
N
T
I
E
YFV
N
T
TFNY
PT
M
A
E
AYR
V
AA
fig|656440.3.peg.4518
Escherichia coli TA206 (10-458/466)
I
VIGSGP
G
G
E
G
AA
M
G
L
V
K
QG
A
RV
A
V
I
------
ERY
Q
N
V
GG
G
C
THW
G
T
IPSKAL
R
HA
V
SR
I
I
E
FNQN
P
L
-
YS
DHSRL
L
RS
S
F
A
D
IL
NH
A
D
N
VINQ
Q
-
T
R
M
RQ
G
FY
ER
N
H
-
CEI
L
Q
G
N
ARF
V
D
E
H
----
TL
A
L
D
C
P
DG
S
VE
TL
T
AEK
F
VIA
C
GSRP
Y
--
HPT
D
V
DFT
H
PRI
Y
DS
D
S
I
L
S
M
HH
E
P
R
HV
L
I
Y
GAGVIG
C
E
Y
A
S
I
F
RG
MDV
KVDL
I
NT
R
D
RL
L
AF
LD
QE
M
S
DS
L
SYH
F
W
N
SG
VV
I
R
H
N
E
E
Y
E
KI
E
GC
D
---
DGV
I
M
H
L
KS
GKK
--
-
-
--
-
L
KA
D
C
LL
Y
A
N
GR
TG
NT
DS
L
A
L
QNI
G
L
E
T
D
S
RG
Q
L
K
V
N
SMY
Q
T
A
Q
PH
V
YA
V
GDV
I
G
Y
P
S
LA
SA
A
YD
Q
G
R
I
AA
Q
A
L
--
VK
G
E
A
TA
H
LI
--
ED
IP
T
G
IYT
I
PE
ISS
VG
K
TE
QQ
LT
A
M
KV
P
YE
V
G
R
AQ
F
K
HL
A
RA
Q
I
V
G
MNV
G
TL
K
I
L
F
HR
E
T
K
EIL
G
IHCF
G
ER
A
A
E
I
I
H
IG
Q
AIM
E
Q
KGG
G
N
T
I
E
YFV
N
T
TFNY
PT
M
A
E
AYR
V
AA
fig|656443.3.peg.4938
Escherichia coli TA271 (10-458/466)
I
VIGSGP
G
G
E
G
AA
M
G
L
V
K
QG
A
RV
A
V
I
------
ERY
Q
N
V
GG
G
C
THW
G
T
IPSKAL
R
HA
V
SR
I
I
E
FNQN
P
L
-
YS
DHSRL
L
RS
S
F
A
D
IL
NH
A
D
N
VINQ
Q
-
T
R
M
RQ
G
FY
ER
N
H
-
CEI
L
Q
G
N
ARF
V
D
E
H
----
TL
A
L
D
C
P
DG
S
VE
TL
T
AEK
F
VIA
C
GSRP
Y
--
HPT
D
V
DFT
H
PRI
Y
DS
D
S
I
L
S
M
HH
E
P
R
HV
L
I
Y
GAGVIG
C
E
Y
A
S
I
F
RG
MDV
KVDL
I
NT
R
D
RL
L
AF
LD
QE
M
S
DS
L
SYH
F
W
N
SG
VV
I
R
H
N
E
E
Y
E
KI
E
GC
D
---
DGV
I
M
H
L
KS
GKK
--
-
-
--
-
L
KA
D
C
LL
Y
A
N
GR
TG
NT
DS
L
A
L
QNI
G
L
E
T
D
S
RG
Q
L
K
V
N
SMY
Q
T
A
Q
PH
V
YA
V
GDV
I
G
Y
P
S
LA
SA
A
YD
Q
G
R
I
AA
Q
A
L
--
VK
G
E
A
TA
H
LI
--
ED
IP
T
G
IYT
I
PE
ISS
VG
K
TE
QQ
LT
A
M
KV
P
YE
V
G
R
AQ
F
K
HL
A
RA
Q
I
V
G
MNV
G
TL
K
I
L
F
HR
E
T
K
EIL
G
IHCF
G
ER
A
A
E
I
I
H
IG
Q
AIM
E
Q
KGG
G
N
T
I
E
YFV
N
T
TFNY
PT
M
A
E
AYR
V
AA
fig|656444.3.peg.5353
Escherichia coli TA280 (10-458/466)
I
VIGSGP
G
G
E
G
AA
M
G
L
V
K
QG
A
RV
A
V
I
------
ERY
Q
N
V
GG
G
C
THW
G
T
IPSKAL
R
HA
V
SR
I
I
E
FNQN
P
L
-
YS
DHSRL
L
RS
S
F
A
D
IL
NH
A
D
N
VINQ
Q
-
T
R
M
RQ
G
FY
ER
N
H
-
CEI
L
Q
G
N
ARF
V
D
E
H
----
TL
A
L
D
C
P
DG
S
VE
TL
T
AEK
F
VIA
C
GSRP
Y
--
HPT
D
V
DFT
H
PRI
Y
DS
D
S
I
L
S
M
HH
E
P
R
HV
L
I
Y
GAGVIG
C
E
Y
A
S
I
F
RG
MDV
KVDL
I
NT
R
D
RL
L
AF
LD
QE
M
S
DS
L
SYH
F
W
N
SG
VV
I
R
H
N
E
E
Y
E
KI
E
GC
D
---
DGV
I
M
H
L
KS
GKK
--
-
-
--
-
L
KA
D
C
LL
Y
A
N
GR
TG
NT
DS
L
A
L
QNI
G
L
E
T
D
S
RG
Q
L
K
V
N
SMY
Q
T
A
Q
PH
V
YA
V
GDV
I
G
Y
P
S
LA
SA
A
YD
Q
G
R
I
AA
Q
A
L
--
VK
G
E
A
TA
H
LI
--
ED
IP
T
G
IYT
I
PE
ISS
VG
K
TE
QQ
LT
A
M
KV
P
YE
V
G
R
AQ
F
K
HL
A
RA
Q
I
V
G
MNV
G
TL
K
I
L
F
HR
E
T
K
EIL
G
IHCF
G
ER
A
A
E
I
I
H
IG
Q
AIM
E
Q
KGG
G
N
T
I
E
YFV
N
T
TFNY
PT
M
A
E
AYR
V
AA
fig|869729.3.peg.4314
Escherichia coli UM146 (10-458/466)
I
VIGSGP
G
G
E
G
AA
M
G
L
V
K
QG
A
RV
A
V
I
------
ERY
Q
N
V
GG
G
C
THW
G
T
IPSKAL
R
HA
V
SR
I
I
E
FNQN
P
L
-
YS
DHSRL
L
RS
S
F
A
D
IL
NH
A
D
N
VINQ
Q
-
T
R
M
RQ
G
FY
ER
N
H
-
CEI
L
Q
G
N
ARF
V
D
E
H
----
TL
A
L
D
C
P
DG
S
VE
TL
T
AEK
F
VIA
C
GSRP
Y
--
HPT
D
V
DFT
H
PRI
Y
DS
D
S
I
L
S
M
HH
E
P
R
HV
L
I
Y
GAGVIG
C
E
Y
A
S
I
F
RG
MDV
KVDL
I
NT
R
D
RL
L
AF
LD
QE
M
S
DS
L
SYH
F
W
N
SG
VV
I
R
H
N
E
E
Y
E
KI
E
GC
D
---
DGV
I
M
H
L
KS
GKK
--
-
-
--
-
L
KA
D
C
LL
Y
A
N
GR
TG
NT
DS
L
A
L
QNI
G
L
E
T
D
S
RG
Q
L
K
V
N
SMY
Q
T
A
Q
PH
V
YA
V
GDV
I
G
Y
P
S
LA
SA
A
YD
Q
G
R
I
AA
Q
A
L
--
VK
G
E
A
TA
H
LI
--
ED
IP
T
G
IYT
I
PE
ISS
VG
K
TE
QQ
LT
A
M
KV
P
YE
V
G
R
AQ
F
K
HL
A
RA
Q
I
V
G
MNV
G
TL
K
I
L
F
HR
E
T
K
EIL
G
IHCF
G
ER
A
A
E
I
I
H
IG
Q
AIM
E
Q
KGG
G
N
T
I
E
YFV
N
T
TFNY
PT
M
A
E
AYR
V
AA
fig|585056.7.peg.4663
Escherichia coli UMN026 (10-458/466)
I
VIGSGP
G
G
E
G
AA
M
G
L
V
K
QG
A
RV
A
V
I
------
ERY
Q
N
V
GG
G
C
THW
G
T
IPSKAL
R
HA
V
SR
I
I
E
FNQN
P
L
-
YS
DHSRL
L
RS
S
F
A
D
IL
NH
A
D
N
VINQ
Q
-
T
R
M
RQ
G
FY
ER
N
H
-
CEI
L
Q
G
N
ARF
V
D
E
H
----
TL
A
L
D
C
P
DG
S
VE
TL
T
AEK
F
VIA
C
GSRP
Y
--
HPT
D
V
DFT
H
PRI
Y
DS
D
S
I
L
S
M
HH
E
P
R
HV
L
I
Y
GAGVIG
C
E
Y
A
S
I
F
RG
MDV
KVDL
I
NT
R
D
RL
L
AF
LD
QE
M
S
DS
L
SYH
F
W
N
SG
VV
I
R
H
N
E
E
Y
E
KI
E
GC
D
---
DGV
I
M
H
L
KS
GKK
--
-
-
--
-
L
KA
D
C
LL
Y
A
N
GR
TG
NT
DS
L
A
L
QNI
G
L
E
T
D
S
RG
Q
L
K
V
N
SMY
Q
T
A
Q
PH
V
YA
V
GDV
I
G
Y
P
S
LA
SA
A
YD
Q
G
R
I
AA
Q
A
L
--
VK
G
E
A
TA
H
LI
--
ED
IP
T
G
IYT
I
PE
ISS
VG
K
TE
QQ
LT
A
M
KV
P
YE
V
G
R
AQ
F
K
HL
A
RA
Q
I
V
G
MNV
G
TL
K
I
L
F
HR
E
T
K
EIL
G
IHCF
G
ER
A
A
E
I
I
H
IG
Q
AIM
E
Q
KGG
G
N
T
I
E
YFV
N
T
TFNY
PT
M
A
E
AYR
V
AA
fig|364106.7.peg.4442
Escherichia coli UTI89 (10-458/466)
I
VIGSGP
G
G
E
G
AA
M
G
L
V
K
QG
A
RV
A
V
I
------
ERY
Q
N
V
GG
G
C
THW
G
T
IPSKAL
R
HA
V
SR
I
I
E
FNQN
P
L
-
YS
DHSRL
L
RS
S
F
A
D
IL
NH
A
D
N
VINQ
Q
-
T
R
M
RQ
G
FY
ER
N
H
-
CEI
L
Q
G
N
ARF
V
D
E
H
----
TL
A
L
D
C
P
DG
S
VE
TL
T
AEK
F
VIA
C
GSRP
Y
--
HPT
D
V
DFT
H
PRI
Y
DS
D
S
I
L
S
M
HH
E
P
R
HV
L
I
Y
GAGVIG
C
E
Y
A
S
I
F
RG
MDV
KVDL
I
NT
R
D
RL
L
AF
LD
QE
M
S
DS
L
SYH
F
W
N
SG
VV
I
R
H
N
E
E
Y
E
KI
E
GC
D
---
DGV
I
M
H
L
KS
GKK
--
-
-
--
-
L
KA
D
C
LL
Y
A
N
GR
TG
NT
DS
L
A
L
QNI
G
L
E
T
D
S
RG
Q
L
K
V
N
SMY
Q
T
A
Q
PH
V
YA
V
GDV
I
G
Y
P
S
LA
SA
A
YD
Q
G
R
I
AA
Q
A
L
--
VK
G
E
A
TA
H
LI
--
ED
IP
T
G
IYT
I
PE
ISS
VG
K
TE
QQ
LT
A
M
KV
P
YE
V
G
R
AQ
F
K
HL
A
RA
Q
I
V
G
MNV
G
TL
K
I
L
F
HR
E
T
K
EIL
G
IHCF
G
ER
A
A
E
I
I
H
IG
Q
AIM
E
Q
KGG
G
N
T
I
E
YFV
N
T
TFNY
PT
M
A
E
AYR
V
AA
fig|364106.8.peg.4443
Escherichia coli UTI89 (10-458/466)
I
VIGSGP
G
G
E
G
AA
M
G
L
V
K
QG
A
RV
A
V
I
------
ERY
Q
N
V
GG
G
C
THW
G
T
IPSKAL
R
HA
V
SR
I
I
E
FNQN
P
L
-
YS
DHSRL
L
RS
S
F
A
D
IL
NH
A
D
N
VINQ
Q
-
T
R
M
RQ
G
FY
ER
N
H
-
CEI
L
Q
G
N
ARF
V
D
E
H
----
TL
A
L
D
C
P
DG
S
VE
TL
T
AEK
F
VIA
C
GSRP
Y
--
HPT
D
V
DFT
H
PRI
Y
DS
D
S
I
L
S
M
HH
E
P
R
HV
L
I
Y
GAGVIG
C
E
Y
A
S
I
F
RG
MDV
KVDL
I
NT
R
D
RL
L
AF
LD
QE
M
S
DS
L
SYH
F
W
N
SG
VV
I
R
H
N
E
E
Y
E
KI
E
GC
D
---
DGV
I
M
H
L
KS
GKK
--
-
-
--
-
L
KA
D
C
LL
Y
A
N
GR
TG
NT
DS
L
A
L
QNI
G
L
E
T
D
S
RG
Q
L
K
V
N
SMY
Q
T
A
Q
PH
V
YA
V
GDV
I
G
Y
P
S
LA
SA
A
YD
Q
G
R
I
AA
Q
A
L
--
VK
G
E
A
TA
H
LI
--
ED
IP
T
G
IYT
I
PE
ISS
VG
K
TE
QQ
LT
A
M
KV
P
YE
V
G
R
AQ
F
K
HL
A
RA
Q
I
V
G
MNV
G
TL
K
I
L
F
HR
E
T
K
EIL
G
IHCF
G
ER
A
A
E
I
I
H
IG
Q
AIM
E
Q
KGG
G
N
T
I
E
YFV
N
T
TFNY
PT
M
A
E
AYR
V
AA
fig|566546.3.peg.4490
Escherichia coli W (10-458/466)
I
VIGSGP
G
G
E
G
AA
M
G
L
V
K
QG
A
RV
A
V
I
------
ERY
Q
N
V
GG
G
C
THW
G
T
IPSKAL
R
HA
V
SR
I
I
E
FNQN
P
L
-
YS
DHSRL
L
RS
S
F
A
D
IL
NH
A
D
N
VINQ
Q
-
T
R
M
RQ
G
FY
ER
N
H
-
CEI
L
Q
G
N
ARF
V
D
E
H
----
TL
A
L
D
C
P
DG
S
VE
TL
T
AEK
F
VIA
C
GSRP
Y
--
HPT
D
V
DFT
H
PRI
Y
DS
D
S
I
L
S
M
HH
E
P
R
HV
L
I
Y
GAGVIG
C
E
Y
A
S
I
F
RG
MDV
KVDL
I
NT
R
D
RL
L
AF
LD
QE
M
S
DS
L
SYH
F
W
N
SG
VV
I
R
H
N
E
E
Y
E
KI
E
GC
D
---
DGV
I
M
H
L
KS
GKK
--
-
-
--
-
L
KA
D
C
LL
Y
A
N
GR
TG
NT
DS
L
A
L
QNI
G
L
E
T
D
S
RG
Q
L
K
V
N
SMY
Q
T
A
Q
PH
V
YA
V
GDV
I
G
Y
P
S
LA
SA
A
YD
Q
G
R
I
AA
Q
A
L
--
VK
G
E
A
TA
H
LI
--
ED
IP
T
G
IYT
I
PE
ISS
VG
K
TE
QQ
LT
A
M
KV
P
YE
V
G
R
AQ
F
K
HL
A
RA
Q
I
V
G
MNV
G
TL
K
I
L
F
HR
E
T
K
EIL
G
IHCF
G
ER
A
A
E
I
I
H
IG
Q
AIM
E
Q
KGG
G
N
T
I
E
YFV
N
T
TFNY
PT
M
A
E
AYR
V
AA
fig|566546.4.peg.4260
Escherichia coli W (10-458/466)
I
VIGSGP
G
G
E
G
AA
M
G
L
V
K
QG
A
RV
A
V
I
------
ERY
Q
N
V
GG
G
C
THW
G
T
IPSKAL
R
HA
V
SR
I
I
E
FNQN
P
L
-
YS
DHSRL
L
RS
S
F
A
D
IL
NH
A
D
N
VINQ
Q
-
T
R
M
RQ
G
FY
ER
N
H
-
CEI
L
Q
G
N
ARF
V
D
E
H
----
TL
A
L
D
C
P
DG
S
VE
TL
T
AEK
F
VIA
C
GSRP
Y
--
HPT
D
V
DFT
H
PRI
Y
DS
D
S
I
L
S
M
HH
E
P
R
HV
L
I
Y
GAGVIG
C
E
Y
A
S
I
F
RG
MDV
KVDL
I
NT
R
D
RL
L
AF
LD
QE
M
S
DS
L
SYH
F
W
N
SG
VV
I
R
H
N
E
E
Y
E
KI
E
GC
D
---
DGV
I
M
H
L
KS
GKK
--
-
-
--
-
L
KA
D
C
LL
Y
A
N
GR
TG
NT
DS
L
A
L
QNI
G
L
E
T
D
S
RG
Q
L
K
V
N
SMY
Q
T
A
Q
PH
V
YA
V
GDV
I
G
Y
P
S
LA
SA
A
YD
Q
G
R
I
AA
Q
A
L
--
VK
G
E
A
TA
H
LI
--
ED
IP
T
G
IYT
I
PE
ISS
VG
K
TE
QQ
LT
A
M
KV
P
YE
V
G
R
AQ
F
K
HL
A
RA
Q
I
V
G
MNV
G
TL
K
I
L
F
HR
E
T
K
EIL
G
IHCF
G
ER
A
A
E
I
I
H
IG
Q
AIM
E
Q
KGG
G
N
T
I
E
YFV
N
T
TFNY
PT
M
A
E
AYR
V
AA
fig|316407.3.peg.3184
Escherichia coli W3110 (10-458/466)
I
VIGSGP
G
G
E
G
AA
M
G
L
V
K
QG
A
RV
A
V
I
------
ERY
Q
N
V
GG
G
C
THW
G
T
IPSKAL
R
HA
V
SR
I
I
E
FNQN
P
L
-
YS
DHSRL
L
RS
S
F
A
D
IL
NH
A
D
N
VINQ
Q
-
T
R
M
RQ
G
FY
ER
N
H
-
CEI
L
Q
G
N
ARF
V
D
E
H
----
TL
A
L
D
C
P
DG
S
VE
TL
T
AEK
F
VIA
C
GSRP
Y
--
HPT
D
V
DFT
H
PRI
Y
DS
D
S
I
L
S
M
HH
E
P
R
HV
L
I
Y
GAGVIG
C
E
Y
A
S
I
F
RG
MDV
KVDL
I
NT
R
D
RL
L
AF
LD
QE
M
S
DS
L
SYH
F
W
N
SG
VV
I
R
H
N
E
E
Y
E
KI
E
GC
D
---
DGV
I
M
H
L
KS
GKK
--
-
-
--
-
L
KA
D
C
LL
Y
A
N
GR
TG
NT
DS
L
A
L
QNI
G
L
E
T
D
S
RG
Q
L
K
V
N
SMY
Q
T
A
Q
PH
V
YA
V
GDV
I
G
Y
P
S
LA
SA
A
YD
Q
G
R
I
AA
Q
A
L
--
VK
G
E
A
TA
H
LI
--
ED
IP
T
G
IYT
I
PE
ISS
VG
K
TE
QQ
LT
A
M
KV
P
YE
V
G
R
AQ
F
K
HL
A
RA
Q
I
V
G
MNV
G
TL
K
I
L
F
HR
E
T
K
EIL
G
IHCF
G
ER
A
A
E
I
I
H
IG
Q
AIM
E
Q
KGG
G
N
T
I
E
YFV
N
T
TFNY
PT
M
A
E
AYR
V
AA
fig|562.376.peg.1316
Escherichia coli WV_060327 (10-458/466)
I
VIGSGP
G
G
E
G
AA
M
G
L
V
K
QG
A
RV
A
V
I
------
ERY
Q
N
V
GG
G
C
THW
G
T
IPSKAL
R
HA
V
SR
I
I
E
FNQN
P
L
-
YS
DHSRL
L
RS
S
F
A
D
IL
NH
A
D
N
VINQ
Q
-
T
R
M
RQ
G
FY
ER
N
H
-
CEI
L
Q
G
N
ARF
V
D
E
H
----
TL
A
L
D
C
P
DG
S
VE
TL
T
AEK
F
VIA
C
GSRP
Y
--
HPT
D
V
DFT
H
PRI
Y
DS
D
S
I
L
S
M
HH
E
P
R
HV
L
I
Y
GAGVIG
C
E
Y
A
S
I
F
RG
MDV
KVDL
I
NT
R
D
RL
L
AF
LD
QE
M
S
DS
L
SYH
F
W
N
SG
VV
I
R
H
N
E
E
Y
E
KI
E
GC
D
---
DGV
I
M
H
L
KS
GKK
--
-
-
--
-
L
KA
D
C
LL
Y
A
N
GR
TG
NT
DS
L
A
L
QNI
G
L
E
T
D
S
RG
Q
L
K
V
N
SMY
Q
T
A
Q
PH
V
YA
V
GDV
I
G
Y
P
S
LA
SA
A
YD
Q
G
R
I
AA
Q
A
L
--
VK
G
E
A
TA
H
LI
--
ED
IP
T
G
IYT
I
PE
ISS
VG
K
TE
QQ
LT
A
M
KV
P
YE
V
G
R
AQ
F
K
HL
A
RA
Q
I
V
G
MNV
G
TL
K
I
L
F
HR
E
T
K
EIL
G
IHCF
G
ER
A
A
E
I
I
H
IG
Q
AIM
E
Q
KGG
G
N
T
I
E
YFV
N
T
TFNY
PT
M
A
E
AYR
V
AA
fig|316385.7.peg.4186
Escherichia coli str. K-12 substr. DH10B (10-458/466)
I
VIGSGP
G
G
E
G
AA
M
G
L
V
K
QG
A
RV
A
V
I
------
ERY
Q
N
V
GG
G
C
THW
G
T
IPSKAL
R
HA
V
SR
I
I
E
FNQN
P
L
-
YS
DHSRL
L
RS
S
F
A
D
IL
NH
A
D
N
VINQ
Q
-
T
R
M
RQ
G
FY
ER
N
H
-
CEI
L
Q
G
N
ARF
V
D
E
H
----
TL
A
L
D
C
P
DG
S
VE
TL
T
AEK
F
VIA
C
GSRP
Y
--
HPT
D
V
DFT
H
PRI
Y
DS
D
S
I
L
S
M
HH
E
P
R
HV
L
I
Y
GAGVIG
C
E
Y
A
S
I
F
RG
MDV
KVDL
I
NT
R
D
RL
L
AF
LD
QE
M
S
DS
L
SYH
F
W
N
SG
VV
I
R
H
N
E
E
Y
E
KI
E
GC
D
---
DGV
I
M
H
L
KS
GKK
--
-
-
--
-
L
KA
D
C
LL
Y
A
N
GR
TG
NT
DS
L
A
L
QNI
G
L
E
T
D
S
RG
Q
L
K
V
N
SMY
Q
T
A
Q
PH
V
YA
V
GDV
I
G
Y
P
S
LA
SA
A
YD
Q
G
R
I
AA
Q
A
L
--
VK
G
E
A
TA
H
LI
--
ED
IP
T
G
IYT
I
PE
ISS
VG
K
TE
QQ
LT
A
M
KV
P
YE
V
G
R
AQ
F
K
HL
A
RA
Q
I
V
G
MNV
G
TL
K
I
L
F
HR
E
T
K
EIL
G
IHCF
G
ER
A
A
E
I
I
H
IG
Q
AIM
E
Q
KGG
G
N
T
I
E
YFV
N
T
TFNY
PT
M
A
E
AYR
V
AA
fig|511145.12.peg.4083
Escherichia coli str. K-12 substr. MG1655 (10-458/466)
I
VIGSGP
G
G
E
G
AA
M
G
L
V
K
QG
A
RV
A
V
I
------
ERY
Q
N
V
GG
G
C
THW
G
T
IPSKAL
R
HA
V
SR
I
I
E
FNQN
P
L
-
YS
DHSRL
L
RS
S
F
A
D
IL
NH
A
D
N
VINQ
Q
-
T
R
M
RQ
G
FY
ER
N
H
-
CEI
L
Q
G
N
ARF
V
D
E
H
----
TL
A
L
D
C
P
DG
S
VE
TL
T
AEK
F
VIA
C
GSRP
Y
--
HPT
D
V
DFT
H
PRI
Y
DS
D
S
I
L
S
M
HH
E
P
R
HV
L
I
Y
GAGVIG
C
E
Y
A
S
I
F
RG
MDV
KVDL
I
NT
R
D
RL
L
AF
LD
QE
M
S
DS
L
SYH
F
W
N
SG
VV
I
R
H
N
E
E
Y
E
KI
E
GC
D
---
DGV
I
M
H
L
KS
GKK
--
-
-
--
-
L
KA
D
C
LL
Y
A
N
GR
TG
NT
DS
L
A
L
QNI
G
L
E
T
D
S
RG
Q
L
K
V
N
SMY
Q
T
A
Q
PH
V
YA
V
GDV
I
G
Y
P
S
LA
SA
A
YD
Q
G
R
I
AA
Q
A
L
--
VK
G
E
A
TA
H
LI
--
ED
IP
T
G
IYT
I
PE
ISS
VG
K
TE
QQ
LT
A
M
KV
P
YE
V
G
R
AQ
F
K
HL
A
RA
Q
I
V
G
MNV
G
TL
K
I
L
F
HR
E
T
K
EIL
G
IHCF
G
ER
A
A
E
I
I
H
IG
Q
AIM
E
Q
KGG
G
N
T
I
E
YFV
N
T
TFNY
PT
M
A
E
AYR
V
AA
fig|511145.6.peg.4065
Escherichia coli str. K-12 substr. MG1655 (10-458/466)
I
VIGSGP
G
G
E
G
AA
M
G
L
V
K
QG
A
RV
A
V
I
------
ERY
Q
N
V
GG
G
C
THW
G
T
IPSKAL
R
HA
V
SR
I
I
E
FNQN
P
L
-
YS
DHSRL
L
RS
S
F
A
D
IL
NH
A
D
N
VINQ
Q
-
T
R
M
RQ
G
FY
ER
N
H
-
CEI
L
Q
G
N
ARF
V
D
E
H
----
TL
A
L
D
C
P
DG
S
VE
TL
T
AEK
F
VIA
C
GSRP
Y
--
HPT
D
V
DFT
H
PRI
Y
DS
D
S
I
L
S
M
HH
E
P
R
HV
L
I
Y
GAGVIG
C
E
Y
A
S
I
F
RG
MDV
KVDL
I
NT
R
D
RL
L
AF
LD
QE
M
S
DS
L
SYH
F
W
N
SG
VV
I
R
H
N
E
E
Y
E
KI
E
GC
D
---
DGV
I
M
H
L
KS
GKK
--
-
-
--
-
L
KA
D
C
LL
Y
A
N
GR
TG
NT
DS
L
A
L
QNI
G
L
E
T
D
S
RG
Q
L
K
V
N
SMY
Q
T
A
Q
PH
V
YA
V
GDV
I
G
Y
P
S
LA
SA
A
YD
Q
G
R
I
AA
Q
A
L
--
VK
G
E
A
TA
H
LI
--
ED
IP
T
G
IYT
I
PE
ISS
VG
K
TE
QQ
LT
A
M
KV
P
YE
V
G
R
AQ
F
K
HL
A
RA
Q
I
V
G
MNV
G
TL
K
I
L
F
HR
E
T
K
EIL
G
IHCF
G
ER
A
A
E
I
I
H
IG
Q
AIM
E
Q
KGG
G
N
T
I
E
YFV
N
T
TFNY
PT
M
A
E
AYR
V
AA
fig|670897.3.peg.1089
Escherichia coli 2362-75 (10-458/466)
I
VIGSGP
G
G
E
G
AA
M
G
L
V
K
QG
A
RV
A
V
I
------
ERY
Q
N
V
GG
G
C
THW
G
T
IPSKAL
R
HA
V
SR
I
I
E
FNQN
P
L
-
YS
DHSRL
L
RS
S
F
A
D
IL
NH
A
D
N
VINQ
Q
-
T
R
M
RQ
G
FY
ER
N
H
-
CEI
L
Q
G
N
ARF
V
D
E
H
----
TL
A
L
D
C
P
DG
S
VE
TL
T
AEK
F
VIA
C
GSRP
Y
--
HPT
D
V
DFP
H
PRI
Y
DS
D
S
I
L
S
M
HH
E
P
R
HV
L
I
Y
GAGVIG
C
E
Y
A
S
I
F
RG
MDV
KVDL
I
NT
R
D
RL
L
AF
LD
QE
M
S
DS
L
SYH
F
W
N
SG
VV
I
R
H
N
E
E
Y
E
KI
E
GC
D
---
DGV
I
M
H
L
KS
GKK
--
-
-
--
-
L
KA
D
C
LL
Y
A
N
GR
TG
NT
DS
L
A
L
QNI
G
L
E
T
D
S
RG
Q
L
K
V
N
SMY
Q
T
A
Q
PH
V
YA
V
GDV
I
G
Y
P
S
LA
SA
A
YD
Q
G
R
I
AA
Q
A
L
--
VK
G
E
A
TA
H
LI
--
ED
IP
T
G
IYT
I
PE
ISS
VG
K
TE
QQ
LT
A
M
KV
P
YE
V
G
R
AQ
F
K
HL
A
RA
Q
I
V
G
MNV
G
TL
K
I
L
F
HR
E
T
K
EIL
G
IHCF
G
ER
A
A
E
I
I
H
IG
Q
AIM
E
Q
KGG
G
N
T
I
E
YFV
N
T
TFNY
PT
M
A
E
AYR
V
AA
fig|216593.1.peg.4809
Escherichia coli E2348/69 (10-458/466)
I
VIGSGP
G
G
E
G
AA
M
G
L
V
K
QG
A
RV
A
V
I
------
ERY
Q
N
V
GG
G
C
THW
G
T
IPSKAL
R
HA
V
SR
I
I
E
FNQN
P
L
-
YS
DHSRL
L
RS
S
F
A
D
IL
NH
A
D
N
VINQ
Q
-
T
R
M
RQ
G
FY
ER
N
H
-
CEI
L
Q
G
N
ARF
V
D
E
H
----
TL
A
L
D
C
P
DG
S
VE
TL
T
AEK
F
VIA
C
GSRP
Y
--
HPT
D
V
DFP
H
PRI
Y
DS
D
S
I
L
S
M
HH
E
P
R
HV
L
I
Y
GAGVIG
C
E
Y
A
S
I
F
RG
MDV
KVDL
I
NT
R
D
RL
L
AF
LD
QE
M
S
DS
L
SYH
F
W
N
SG
VV
I
R
H
N
E
E
Y
E
KI
E
GC
D
---
DGV
I
M
H
L
KS
GKK
--
-
-
--
-
L
KA
D
C
LL
Y
A
N
GR
TG
NT
DS
L
A
L
QNI
G
L
E
T
D
S
RG
Q
L
K
V
N
SMY
Q
T
A
Q
PH
V
YA
V
GDV
I
G
Y
P
S
LA
SA
A
YD
Q
G
R
I
AA
Q
A
L
--
VK
G
E
A
TA
H
LI
--
ED
IP
T
G
IYT
I
PE
ISS
VG
K
TE
QQ
LT
A
M
KV
P
YE
V
G
R
AQ
F
K
HL
A
RA
Q
I
V
G
MNV
G
TL
K
I
L
F
HR
E
T
K
EIL
G
IHCF
G
ER
A
A
E
I
I
H
IG
Q
AIM
E
Q
KGG
G
N
T
I
E
YFV
N
T
TFNY
PT
M
A
E
AYR
V
AA
fig|358709.5.peg.2943
Escherichia coli 101-1 (10-458/466)
I
VIGSGP
G
G
E
G
AA
M
G
L
V
K
QG
A
RV
A
V
I
------
ERY
Q
N
V
GG
G
C
THW
G
T
IPSKAL
R
HA
V
SR
I
I
E
FNQN
P
L
-
YS
DHSRL
L
RS
S
F
A
D
IL
NH
A
D
N
VINQ
Q
-
T
R
M
RQ
G
FY
ER
N
H
-
CEI
L
Q
G
N
ARF
V
D
E
H
----
TL
A
L
D
C
L
DG
S
VE
TL
T
AEK
F
VIA
C
GSRP
Y
--
HPT
D
V
DFT
H
PRI
Y
DS
D
S
I
L
S
M
HH
E
P
R
HV
L
I
Y
GAGVIG
C
E
Y
A
S
I
F
RG
MDV
KVDL
I
NT
R
D
RL
L
AF
LD
QE
M
S
DS
L
SYH
F
W
N
SG
VV
I
R
H
N
E
E
Y
E
KI
E
GC
D
---
DGV
I
M
H
L
KS
GKK
--
-
-
--
-
L
KA
D
C
LL
Y
A
N
GR
TG
NT
DS
L
A
L
QNI
G
L
E
T
D
S
RG
Q
L
K
V
N
SMY
Q
T
A
Q
PH
V
YA
V
GDV
I
G
Y
P
S
LA
SA
A
YD
Q
G
R
I
AA
Q
A
L
--
VK
G
E
A
TA
H
LI
--
ED
IP
T
G
IYT
I
PE
ISS
VG
K
TE
QQ
LT
A
M
KV
P
YE
V
G
R
AQ
F
K
HL
A
RA
Q
I
V
G
MNV
G
TL
K
I
L
F
HR
E
T
K
EIL
G
IHCF
G
ER
A
A
E
I
I
H
IG
Q
AIM
E
Q
KGG
G
N
T
I
E
YFV
N
T
TFNY
PT
M
A
E
AYR
V
AA
fig|413997.3.peg.4044
Escherichia coli B str. REL606 (10-458/466)
I
VIGSGP
G
G
E
G
AA
M
G
L
V
K
QG
A
RV
A
V
I
------
ERY
Q
N
V
GG
G
C
THW
G
T
IPSKAL
R
HA
V
SR
I
I
E
FNQN
P
L
-
YS
DHSRL
L
RS
S
F
A
D
IL
NH
A
D
N
VINQ
Q
-
T
R
M
RQ
G
FY
ER
N
H
-
CEI
L
Q
G
N
ARF
V
D
E
H
----
TL
A
L
D
C
L
DG
S
VE
TL
T
AEK
F
VIA
C
GSRP
Y
--
HPT
D
V
DFT
H
PRI
Y
DS
D
S
I
L
S
M
HH
E
P
R
HV
L
I
Y
GAGVIG
C
E
Y
A
S
I
F
RG
MDV
KVDL
I
NT
R
D
RL
L
AF
LD
QE
M
S
DS
L
SYH
F
W
N
SG
VV
I
R
H
N
E
E
Y
E
KI
E
GC
D
---
DGV
I
M
H
L
KS
GKK
--
-
-
--
-
L
KA
D
C
LL
Y
A
N
GR
TG
NT
DS
L
A
L
QNI
G
L
E
T
D
S
RG
Q
L
K
V
N
SMY
Q
T
A
Q
PH
V
YA
V
GDV
I
G
Y
P
S
LA
SA
A
YD
Q
G
R
I
AA
Q
A
L
--
VK
G
E
A
TA
H
LI
--
ED
IP
T
G
IYT
I
PE
ISS
VG
K
TE
QQ
LT
A
M
KV
P
YE
V
G
R
AQ
F
K
HL
A
RA
Q
I
V
G
MNV
G
TL
K
I
L
F
HR
E
T
K
EIL
G
IHCF
G
ER
A
A
E
I
I
H
IG
Q
AIM
E
Q
KGG
G
N
T
I
E
YFV
N
T
TFNY
PT
M
A
E
AYR
V
AA
fig|511693.5.peg.4063
Escherichia coli BL21 (10-458/466)
I
VIGSGP
G
G
E
G
AA
M
G
L
V
K
QG
A
RV
A
V
I
------
ERY
Q
N
V
GG
G
C
THW
G
T
IPSKAL
R
HA
V
SR
I
I
E
FNQN
P
L
-
YS
DHSRL
L
RS
S
F
A
D
IL
NH
A
D
N
VINQ
Q
-
T
R
M
RQ
G
FY
ER
N
H
-
CEI
L
Q
G
N
ARF
V
D
E
H
----
TL
A
L
D
C
L
DG
S
VE
TL
T
AEK
F
VIA
C
GSRP
Y
--
HPT
D
V
DFT
H
PRI
Y
DS
D
S
I
L
S
M
HH
E
P
R
HV
L
I
Y
GAGVIG
C
E
Y
A
S
I
F
RG
MDV
KVDL
I
NT
R
D
RL
L
AF
LD
QE
M
S
DS
L
SYH
F
W
N
SG
VV
I
R
H
N
E
E
Y
E
KI
E
GC
D
---
DGV
I
M
H
L
KS
GKK
--
-
-
--
-
L
KA
D
C
LL
Y
A
N
GR
TG
NT
DS
L
A
L
QNI
G
L
E
T
D
S
RG
Q
L
K
V
N
SMY
Q
T
A
Q
PH
V
YA
V
GDV
I
G
Y
P
S
LA
SA
A
YD
Q
G
R
I
AA
Q
A
L
--
VK
G
E
A
TA
H
LI
--
ED
IP
T
G
IYT
I
PE
ISS
VG
K
TE
QQ
LT
A
M
KV
P
YE
V
G
R
AQ
F
K
HL
A
RA
Q
I
V
G
MNV
G
TL
K
I
L
F
HR
E
T
K
EIL
G
IHCF
G
ER
A
A
E
I
I
H
IG
Q
AIM
E
Q
KGG
G
N
T
I
E
YFV
N
T
TFNY
PT
M
A
E
AYR
V
AA
fig|469008.4.peg.4224
Escherichia coli BL21(DE3) (10-458/466)
I
VIGSGP
G
G
E
G
AA
M
G
L
V
K
QG
A
RV
A
V
I
------
ERY
Q
N
V
GG
G
C
THW
G
T
IPSKAL
R
HA
V
SR
I
I
E
FNQN
P
L
-
YS
DHSRL
L
RS
S
F
A
D
IL
NH
A
D
N
VINQ
Q
-
T
R
M
RQ
G
FY
ER
N
H
-
CEI
L
Q
G
N
ARF
V
D
E
H
----
TL
A
L
D
C
L
DG
S
VE
TL
T
AEK
F
VIA
C
GSRP
Y
--
HPT
D
V
DFT
H
PRI
Y
DS
D
S
I
L
S
M
HH
E
P
R
HV
L
I
Y
GAGVIG
C
E
Y
A
S
I
F
RG
MDV
KVDL
I
NT
R
D
RL
L
AF
LD
QE
M
S
DS
L
SYH
F
W
N
SG
VV
I
R
H
N
E
E
Y
E
KI
E
GC
D
---
DGV
I
M
H
L
KS
GKK
--
-
-
--
-
L
KA
D
C
LL
Y
A
N
GR
TG
NT
DS
L
A
L
QNI
G
L
E
T
D
S
RG
Q
L
K
V
N
SMY
Q
T
A
Q
PH
V
YA
V
GDV
I
G
Y
P
S
LA
SA
A
YD
Q
G
R
I
AA
Q
A
L
--
VK
G
E
A
TA
H
LI
--
ED
IP
T
G
IYT
I
PE
ISS
VG
K
TE
QQ
LT
A
M
KV
P
YE
V
G
R
AQ
F
K
HL
A
RA
Q
I
V
G
MNV
G
TL
K
I
L
F
HR
E
T
K
EIL
G
IHCF
G
ER
A
A
E
I
I
H
IG
Q
AIM
E
Q
KGG
G
N
T
I
E
YFV
N
T
TFNY
PT
M
A
E
AYR
V
AA
fig|749547.3.peg.1063
Escherichia coli MS 187-1 (10-458/466)
I
VIGSGP
G
G
E
G
AA
M
G
L
V
K
QG
A
RV
A
V
I
------
ERY
Q
N
V
GG
G
C
THW
G
T
IPSKAL
R
HA
V
SR
I
I
E
FNQN
P
L
-
YS
DHSRL
L
RS
S
F
A
D
IL
NH
A
D
N
VINQ
Q
-
T
R
M
RQ
G
FY
ER
N
H
-
CEI
L
Q
G
N
ARF
V
D
E
H
----
TL
A
L
D
C
L
DG
S
VE
TL
T
AEK
F
VIA
C
GSRP
Y
--
HPT
D
V
DFT
H
PRI
Y
DS
D
S
I
L
S
M
HH
E
P
R
HV
L
I
Y
GAGVIG
C
E
Y
A
S
I
F
RG
MDV
KVDL
I
NT
R
D
RL
L
AF
LD
QE
M
S
DS
L
SYH
F
W
N
SG
VV
I
R
H
N
E
E
Y
E
KI
E
GC
D
---
DGV
I
M
H
L
KS
GKK
--
-
-
--
-
L
KA
D
C
LL
Y
A
N
GR
TG
NT
DS
L
A
L
QNI
G
L
E
T
D
S
RG
Q
L
K
V
N
SMY
Q
T
A
Q
PH
V
YA
V
GDV
I
G
Y
P
S
LA
SA
A
YD
Q
G
R
I
AA
Q
A
L
--
VK
G
E
A
TA
H
LI
--
ED
IP
T
G
IYT
I
PE
ISS
VG
K
TE
QQ
LT
A
M
KV
P
YE
V
G
R
AQ
F
K
HL
A
RA
Q
I
V
G
MNV
G
TL
K
I
L
F
HR
E
T
K
EIL
G
IHCF
G
ER
A
A
E
I
I
H
IG
Q
AIM
E
Q
KGG
G
N
T
I
E
YFV
N
T
TFNY
PT
M
A
E
AYR
V
AA
fig|1040638.4.peg.142
Escherichia coli O104:H4 str. LB226692 (99-559/564)
HI
A
VIGSG
G
A
AM
A
AA
L
K
A
V
E
QG
A
RV
T
L
I
ER
G
---
---
-
T
I
GG
T
C
V
NVGC
V
PSK
I
MI
R
AA
HI
A
H
L
RRES
P
F
DG
G
IAATT
P
TI
Q
R
T
A
L
L
AQ
Q
Q
A
R
V
DE
L
RH
A
K
YE
G
IL
E
GN
PA
I
T
VL
H
G
S
ARF
K
D
N
R
----
N
L
I
V
Q
L
N
DGG
ER
V
V
A
FD
R
C
L
IA
T
G
A
S
P
A
VPP
I
P
G
L
--K
D
TPY
W
T
ST
E
AL
V
S
ET
I
P
K
RL
A
V
I
G
S
S
V
V
A
LE
L
A
QA
F
AR
LG
A
KV
T
IL
AR
S
T
LF
F-RE
D
PA
I
G
EA
V
TAA
F
RME
G
IE
V
R
E
H
T
Q
A
SQ
V
A
YI
N
GEG
DG
E
F
V
L
-
--
---
-
T
T
A
HG
E
L
R
A
D
K
LLVA
T
GR
A
PNT
RK
L
A
L
DAT
GV
T
L
TP
Q
G
A
I
V
I
D
PGM
RT
S
V
E
HIYA
A
GD
CTD
QP
QFV
Y
V
A
AA
A
G
T
R
AA
I
N
M
--
T
GG
D
A
AL
N
L
---
TA
M
P
A
V
VF
T
D
P
Q
VA
T
VG
Y
S
E
AE
A
HH
D
GI
K
T
D
S
R
T
LT
LD
NV
P
RA
L
A
N
F
DTR
G
FI
KL
V
V
EE
G
S
G
R
L
IG
VQA
V
A
PE
AGELI
Q
TA
A
LAI
R
N
---
R
M
T
V
QEL
A
D
Q
L
F
P
Y
L
T
M
V
E
GLK
LAA
QT
F
NKDVKQ
L
fig|6666666.5357.peg.3086
Escherichia coli TY-2482 (99-559/564)
HI
A
VIGSG
G
A
AM
A
AA
L
K
A
V
E
QG
A
RV
T
L
I
ER
G
---
---
-
T
I
GG
T
C
V
NVGC
V
PSK
I
MI
R
AA
HI
A
H
L
RRES
P
F
DG
G
IAATT
P
TI
Q
R
T
A
L
L
AQ
Q
Q
A
R
V
DE
L
RH
A
K
YE
G
IL
E
GN
PA
I
T
VL
H
G
S
ARF
K
D
N
R
----
N
L
I
V
Q
L
N
DGG
ER
V
V
A
FD
R
C
L
IA
T
G
A
S
P
A
VPP
I
P
G
L
--K
D
TPY
W
T
ST
E
AL
V
S
ET
I
P
K
RL
A
V
I
G
S
S
V
V
A
LE
L
A
QA
F
AR
LG
A
KV
T
IL
AR
S
T
LF
F-RE
D
PA
I
G
EA
V
TAA
F
RME
G
IE
V
R
E
H
T
Q
A
SQ
V
A
YI
N
GEG
DG
E
F
V
L
-
--
---
-
T
T
A
HG
E
L
R
A
D
K
LLVA
T
GR
A
PNT
RK
L
A
L
DAT
GV
T
L
TP
Q
G
A
I
V
I
D
PGM
RT
S
V
E
HIYA
A
GD
CTD
QP
QFV
Y
V
A
AA
A
G
T
R
AA
I
N
M
--
T
GG
D
A
AL
N
L
---
TA
M
P
A
V
VF
T
D
P
Q
VA
T
VG
Y
S
E
AE
A
HH
D
GI
K
T
D
S
R
T
LT
LD
NV
P
RA
L
A
N
F
DTR
G
FI
KL
V
V
EE
G
S
G
R
L
IG
VQA
V
A
PE
AGELI
Q
TA
A
LAI
R
N
---
R
M
T
V
QEL
A
D
Q
L
F
P
Y
L
T
M
V
E
GLK
LAA
QT
F
NKDVKQ
L
fig|216592.1.peg.1099
Escherichia coli 042 (99-559/564)
HI
A
VIGSG
G
A
AM
A
AA
L
K
A
V
E
QG
A
RV
T
L
I
ER
G
---
---
-
T
I
GG
T
C
V
NVGC
V
PSK
I
MI
R
AA
HI
A
H
L
RRES
P
F
DG
G
IAATT
P
TI
Q
R
T
A
L
L
AQ
Q
Q
A
R
V
DE
L
RH
A
K
YE
G
IL
E
GN
PA
I
T
VL
H
G
S
ARF
K
D
N
R
----
N
L
I
V
Q
L
N
DGG
ER
V
V
A
FD
R
C
L
IA
T
G
A
S
P
A
VPP
I
P
G
L
--K
D
TPY
W
T
ST
E
AL
V
S
ET
I
P
K
RL
A
V
I
G
S
S
V
V
A
LE
L
A
QA
F
AR
LG
A
KV
T
IL
AR
S
T
LF
F-RE
D
PA
I
G
EA
V
TAA
F
RME
G
IE
V
R
E
H
T
Q
A
SQ
V
A
YI
N
GEG
DG
E
F
V
L
-
--
---
-
T
T
A
HG
E
L
R
A
D
K
LLVA
T
GR
A
PNT
RK
L
A
L
DAT
GV
T
L
TP
Q
G
A
I
V
I
D
PGM
RT
S
V
E
HIYA
A
GD
CTD
QP
QFV
Y
V
A
AA
A
G
T
R
AA
I
N
M
--
T
GG
D
A
AL
N
L
---
TA
M
P
A
V
VF
T
D
P
Q
VA
T
VG
Y
S
E
AE
A
HH
D
GI
K
T
D
S
R
T
LT
LD
NV
P
RA
L
A
N
F
DTR
G
FI
KL
V
V
EE
G
S
G
R
L
IG
VQA
V
A
PE
AGELI
Q
TA
A
LAI
R
N
---
R
M
T
V
QEL
A
D
Q
L
F
P
Y
L
T
M
V
E
GLK
LAA
QT
F
NKDVKQ
L
fig|344601.3.peg.4874
Escherichia coli B171 (99-559/564)
HI
A
VIGSG
G
A
AM
A
AA
L
K
A
V
E
QG
A
RV
T
L
I
ER
G
---
---
-
T
I
GG
T
C
V
NVGC
V
PSK
I
MI
R
AA
HI
A
H
L
RRES
P
F
DG
G
IAATT
P
TI
Q
R
T
A
L
L
AQ
Q
Q
A
R
V
DE
L
RH
A
K
YE
G
IL
E
GN
PA
I
T
VL
H
G
S
ARF
K
D
N
R
----
N
L
I
V
Q
L
N
DGG
ER
V
V
A
FD
R
C
L
IA
T
G
A
S
P
A
VPP
I
P
G
L
--K
D
TPY
W
T
ST
E
AL
V
S
ET
I
P
K
RL
A
V
I
G
S
S
V
V
A
LE
L
A
QA
F
AR
LG
A
KV
T
IL
AR
S
T
LF
F-RE
D
PA
I
G
EA
V
TAA
F
RME
G
IE
V
R
E
H
T
Q
A
SQ
V
A
YI
N
GEG
DG
E
F
V
L
-
--
---
-
T
T
A
HG
E
L
R
A
D
K
LLVA
T
GR
A
PNT
RK
L
A
L
DAT
GV
T
L
TP
Q
G
A
I
V
I
D
PGM
RT
S
V
E
HIYA
A
GD
CTD
QP
QFV
Y
V
A
AA
A
G
T
R
AA
I
N
M
--
T
GG
D
A
AL
N
L
---
TA
M
P
A
V
VF
T
D
P
Q
VA
T
VG
Y
S
E
AE
A
HH
D
GI
K
T
D
S
R
T
LT
LD
NV
P
RA
L
A
N
F
DTR
G
FI
KL
V
V
EE
G
S
G
R
L
IG
VQA
V
A
PE
AGELI
Q
TA
A
LAI
R
N
---
R
M
T
V
QEL
A
D
Q
L
F
P
Y
L
T
M
V
E
GLK
LAA
QT
F
NKDVKQ
L
fig|216592.3.peg.4256
Escherichia coli 042 (75-535/540)
HI
A
VIGSG
G
A
AM
A
AA
L
K
A
V
E
QG
A
RV
T
L
I
ER
G
---
---
-
T
I
GG
T
C
V
NVGC
V
PSK
I
MI
R
AA
HI
A
H
L
RRES
P
F
DG
G
IAATT
P
TI
Q
R
T
A
L
L
AQ
Q
Q
A
R
V
DE
L
RH
A
K
YE
G
IL
E
GN
PA
I
T
VL
H
G
S
ARF
K
D
N
R
----
N
L
I
V
Q
L
N
DGG
ER
V
V
A
FD
R
C
L
IA
T
G
A
S
P
A
VPP
I
P
G
L
--K
D
TPY
W
T
ST
E
AL
V
S
ET
I
P
K
RL
A
V
I
G
S
S
V
V
A
LE
L
A
QA
F
AR
LG
A
KV
T
IL
AR
S
T
LF
F-RE
D
PA
I
G
EA
V
TAA
F
RME
G
IE
V
R
E
H
T
Q
A
SQ
V
A
YI
N
GEG
DG
E
F
V
L
-
--
---
-
T
T
A
HG
E
L
R
A
D
K
LLVA
T
GR
A
PNT
RK
L
A
L
DAT
GV
T
L
TP
Q
G
A
I
V
I
D
PGM
RT
S
V
E
HIYA
A
GD
CTD
QP
QFV
Y
V
A
AA
A
G
T
R
AA
I
N
M
--
T
GG
D
A
AL
N
L
---
TA
M
P
A
V
VF
T
D
P
Q
VA
T
VG
Y
S
E
AE
A
HH
D
GI
K
T
D
S
R
T
LT
LD
NV
P
RA
L
A
N
F
DTR
G
FI
KL
V
V
EE
G
S
G
R
L
IG
VQA
V
A
PE
AGELI
Q
TA
A
LAI
R
N
---
R
M
T
V
QEL
A
D
Q
L
F
P
Y
L
T
M
V
E
GLK
LAA
QT
F
NKDVKQ
L
fig|358709.5.peg.4618
Escherichia coli 101-1 (75-535/540)
HI
A
VIGSG
G
A
AM
A
AA
L
K
A
V
E
QG
A
RV
T
L
I
ER
G
---
---
-
T
I
GG
T
C
V
NVGC
V
PSK
I
MI
R
AA
HI
A
H
L
RRES
P
F
DG
G
IAATT
P
TI
Q
R
T
A
L
L
AQ
Q
Q
A
R
V
DE
L
RH
A
K
YE
G
IL
E
GN
PA
I
T
VL
H
G
S
ARF
K
D
N
R
----
N
L
I
V
Q
L
N
DGG
ER
V
V
A
FD
R
C
L
IA
T
G
A
S
P
A
VPP
I
P
G
L
--K
D
TPY
W
T
ST
E
AL
V
S
ET
I
P
K
RL
A
V
I
G
S
S
V
V
A
LE
L
A
QA
F
AR
LG
A
KV
T
IL
AR
S
T
LF
F-RE
D
PA
I
G
EA
V
TAA
F
RME
G
IE
V
R
E
H
T
Q
A
SQ
V
A
YI
N
GEG
DG
E
F
V
L
-
--
---
-
T
T
A
HG
E
L
R
A
D
K
LLVA
T
GR
A
PNT
RK
L
A
L
DAT
GV
T
L
TP
Q
G
A
I
V
I
D
PGM
RT
S
V
E
HIYA
A
GD
CTD
QP
QFV
Y
V
A
AA
A
G
T
R
AA
I
N
M
--
T
GG
D
A
AL
N
L
---
TA
M
P
A
V
VF
T
D
P
Q
VA
T
VG
Y
S
E
AE
A
HH
D
GI
K
T
D
S
R
T
LT
LD
NV
P
RA
L
A
N
F
DTR
G
FI
KL
V
V
EE
G
S
G
R
L
IG
VQA
V
A
PE
AGELI
Q
TA
A
LAI
R
N
---
R
M
T
V
QEL
A
D
Q
L
F
P
Y
L
T
M
V
E
GLK
LAA
QT
F
NKDVKQ
L
fig|344601.5.peg.5176
Escherichia coli B171 (75-535/540)
HI
A
VIGSG
G
A
AM
A
AA
L
K
A
V
E
QG
A
RV
T
L
I
ER
G
---
---
-
T
I
GG
T
C
V
NVGC
V
PSK
I
MI
R
AA
HI
A
H
L
RRES
P
F
DG
G
IAATT
P
TI
Q
R
T
A
L
L
AQ
Q
Q
A
R
V
DE
L
RH
A
K
YE
G
IL
E
GN
PA
I
T
VL
H
G
S
ARF
K
D
N
R
----
N
L
I
V
Q
L
N
DGG
ER
V
V
A
FD
R
C
L
IA
T
G
A
S
P
A
VPP
I
P
G
L
--K
D
TPY
W
T
ST
E
AL
V
S
ET
I
P
K
RL
A
V
I
G
S
S
V
V
A
LE
L
A
QA
F
AR
LG
A
KV
T
IL
AR
S
T
LF
F-RE
D
PA
I
G
EA
V
TAA
F
RME
G
IE
V
R
E
H
T
Q
A
SQ
V
A
YI
N
GEG
DG
E
F
V
L
-
--
---
-
T
T
A
HG
E
L
R
A
D
K
LLVA
T
GR
A
PNT
RK
L
A
L
DAT
GV
T
L
TP
Q
G
A
I
V
I
D
PGM
RT
S
V
E
HIYA
A
GD
CTD
QP
QFV
Y
V
A
AA
A
G
T
R
AA
I
N
M
--
T
GG
D
A
AL
N
L
---
TA
M
P
A
V
VF
T
D
P
Q
VA
T
VG
Y
S
E
AE
A
HH
D
GI
K
T
D
S
R
T
LT
LD
NV
P
RA
L
A
N
F
DTR
G
FI
KL
V
V
EE
G
S
G
R
L
IG
VQA
V
A
PE
AGELI
Q
TA
A
LAI
R
N
---
R
M
T
V
QEL
A
D
Q
L
F
P
Y
L
T
M
V
E
GLK
LAA
QT
F
NKDVKQ
L
fig|656380.3.peg.1967
Escherichia coli FVEC1412 (75-535/540)
HI
A
VIGSG
G
A
AM
A
AA
L
K
A
V
E
QG
A
RV
T
L
I
ER
G
---
---
-
T
I
GG
T
C
V
NVGC
V
PSK
I
MI
R
AA
HI
A
H
L
RRES
P
F
DG
G
IAATT
P
TI
Q
R
T
A
L
L
AQ
Q
Q
A
R
V
DE
L
RH
A
K
YE
G
IL
E
GN
PA
I
T
VL
H
G
S
ARF
K
D
N
R
----
N
L
I
V
Q
L
N
DGG
ER
V
V
A
FD
R
C
L
IA
T
G
A
S
P
A
VPP
I
P
G
L
--K
D
TPY
W
T
ST
E
AL
V
S
ET
I
P
K
RL
A
V
I
G
S
S
V
V
A
LE
L
A
QA
F
AR
LG
A
KV
T
IL
AR
S
T
LF
F-RE
D
PA
I
G
EA
V
TAA
F
RME
G
IE
V
R
E
H
T
Q
A
SQ
V
A
YI
N
GEG
DG
E
F
V
L
-
--
---
-
T
T
A
HG
E
L
R
A
D
K
LLVA
T
GR
A
PNT
RK
L
A
L
DAT
GV
T
L
TP
Q
G
A
I
V
I
D
PGM
RT
S
V
E
HIYA
A
GD
CTD
QP
QFV
Y
V
A
AA
A
G
T
R
AA
I
N
M
--
T
GG
D
A
AL
N
L
---
TA
M
P
A
V
VF
T
D
P
Q
VA
T
VG
Y
S
E
AE
A
HH
D
GI
K
T
D
S
R
T
LT
LD
NV
P
RA
L
A
N
F
DTR
G
FI
KL
V
V
EE
G
S
G
R
L
IG
VQA
V
A
PE
AGELI
Q
TA
A
LAI
R
N
---
R
M
T
V
QEL
A
D
Q
L
F
P
Y
L
T
M
V
E
GLK
LAA
QT
F
NKDVKQ
L
fig|656393.3.peg.127
Escherichia coli H299 (75-535/540)
HI
A
VIGSG
G
A
AM
A
AA
L
K
A
V
E
QG
A
RV
T
L
I
ER
G
---
---
-
T
I
GG
T
C
V
NVGC
V
PSK
I
MI
R
AA
HI
A
H
L
RRES
P
F
DG
G
IAATT
P
TI
Q
R
T
A
L
L
AQ
Q
Q
A
R
V
DE
L
RH
A
K
YE
G
IL
E
GN
PA
I
T
VL
H
G
S
ARF
K
D
N
R
----
N
L
I
V
Q
L
N
DGG
ER
V
V
A
FD
R
C
L
IA
T
G
A
S
P
A
VPP
I
P
G
L
--K
D
TPY
W
T
ST
E
AL
V
S
ET
I
P
K
RL
A
V
I
G
S
S
V
V
A
LE
L
A
QA
F
AR
LG
A
KV
T
IL
AR
S
T
LF
F-RE
D
PA
I
G
EA
V
TAA
F
RME
G
IE
V
R
E
H
T
Q
A
SQ
V
A
YI
N
GEG
DG
E
F
V
L
-
--
---
-
T
T
A
HG
E
L
R
A
D
K
LLVA
T
GR
A
PNT
RK
L
A
L
DAT
GV
T
L
TP
Q
G
A
I
V
I
D
PGM
RT
S
V
E
HIYA
A
GD
CTD
QP
QFV
Y
V
A
AA
A
G
T
R
AA
I
N
M
--
T
GG
D
A
AL
N
L
---
TA
M
P
A
V
VF
T
D
P
Q
VA
T
VG
Y
S
E
AE
A
HH
D
GI
K
T
D
S
R
T
LT
LD
NV
P
RA
L
A
N
F
DTR
G
FI
KL
V
V
EE
G
S
G
R
L
IG
VQA
V
A
PE
AGELI
Q
TA
A
LAI
R
N
---
R
M
T
V
QEL
A
D
Q
L
F
P
Y
L
T
M
V
E
GLK
LAA
QT
F
NKDVKQ
L
fig|679205.4.peg.5420
Escherichia coli MS 124-1 (75-535/540)
HI
A
VIGSG
G
A
AM
A
AA
L
K
A
V
E
QG
A
RV
T
L
I
ER
G
---
---
-
T
I
GG
T
C
V
NVGC
V
PSK
I
MI
R
AA
HI
A
H
L
RRES
P
F
DG
G
IAATT
P
TI
Q
R
T
A
L
L
AQ
Q
Q
A
R
V
DE
L
RH
A
K
YE
G
IL
E
GN
PA
I
T
VL
H
G
S
ARF
K
D
N
R
----
N
L
I
V
Q
L
N
DGG
ER
V
V
A
FD
R
C
L
IA
T
G
A
S
P
A
VPP
I
P
G
L
--K
D
TPY
W
T
ST
E
AL
V
S
ET
I
P
K
RL
A
V
I
G
S
S
V
V
A
LE
L
A
QA
F
AR
LG
A
KV
T
IL
AR
S
T
LF
F-RE
D
PA
I
G
EA
V
TAA
F
RME
G
IE
V
R
E
H
T
Q
A
SQ
V
A
YI
N
GEG
DG
E
F
V
L
-
--
---
-
T
T
A
HG
E
L
R
A
D
K
LLVA
T
GR
A
PNT
RK
L
A
L
DAT
GV
T
L
TP
Q
G
A
I
V
I
D
PGM
RT
S
V
E
HIYA
A
GD
CTD
QP
QFV
Y
V
A
AA
A
G
T
R
AA
I
N
M
--
T
GG
D
A
AL
N
L
---
TA
M
P
A
V
VF
T
D
P
Q
VA
T
VG
Y
S
E
AE
A
HH
D
GI
K
T
D
S
R
T
LT
LD
NV
P
RA
L
A
N
F
DTR
G
FI
KL
V
V
EE
G
S
G
R
L
IG
VQA
V
A
PE
AGELI
Q
TA
A
LAI
R
N
---
R
M
T
V
QEL
A
D
Q
L
F
P
Y
L
T
M
V
E
GLK
LAA
QT
F
NKDVKQ
L
fig|749548.3.peg.4371
Escherichia coli MS 196-1 (75-535/540)
HI
A
VIGSG
G
A
AM
A
AA
L
K
A
V
E
QG
A
RV
T
L
I
ER
G
---
---
-
T
I
GG
T
C
V
NVGC
V
PSK
I
MI
R
AA
HI
A
H
L
RRES
P
F
DG
G
IAATT
P
TI
Q
R
T
A
L
L
AQ
Q
Q
A
R
V
DE
L
RH
A
K
YE
G
IL
E
GN
PA
I
T
VL
H
G
S
ARF
K
D
N
R
----
N
L
I
V
Q
L
N
DGG
ER
V
V
A
FD
R
C
L
IA
T
G
A
S
P
A
VPP
I
P
G
L
--K
D
TPY
W
T
ST
E
AL
V
S
ET
I
P
K
RL
A
V
I
G
S
S
V
V
A
LE
L
A
QA
F
AR
LG
A
KV
T
IL
AR
S
T
LF
F-RE
D
PA
I
G
EA
V
TAA
F
RME
G
IE
V
R
E
H
T
Q
A
SQ
V
A
YI
N
GEG
DG
E
F
V
L
-
--
---
-
T
T
A
HG
E
L
R
A
D
K
LLVA
T
GR
A
PNT
RK
L
A
L
DAT
GV
T
L
TP
Q
G
A
I
V
I
D
PGM
RT
S
V
E
HIYA
A
GD
CTD
QP
QFV
Y
V
A
AA
A
G
T
R
AA
I
N
M
--
T
GG
D
A
AL
N
L
---
TA
M
P
A
V
VF
T
D
P
Q
VA
T
VG
Y
S
E
AE
A
HH
D
GI
K
T
D
S
R
T
LT
LD
NV
P
RA
L
A
N
F
DTR
G
FI
KL
V
V
EE
G
S
G
R
L
IG
VQA
V
A
PE
AGELI
Q
TA
A
LAI
R
N
---
R
M
T
V
QEL
A
D
Q
L
F
P
Y
L
T
M
V
E
GLK
LAA
QT
F
NKDVKQ
L
fig|749549.3.peg.179
Escherichia coli MS 198-1 (75-535/540)
HI
A
VIGSG
G
A
AM
A
AA
L
K
A
V
E
QG
A
RV
T
L
I
ER
G
---
---
-
T
I
GG
T
C
V
NVGC
V
PSK
I
MI
R
AA
HI
A
H
L
RRES
P
F
DG
G
IAATT
P
TI
Q
R
T
A
L
L
AQ
Q
Q
A
R
V
DE
L
RH
A
K
YE
G
IL
E
GN
PA
I
T
VL
H
G
S
ARF
K
D
N
R
----
N
L
I
V
Q
L
N
DGG
ER
V
V
A
FD
R
C
L
IA
T
G
A
S
P
A
VPP
I
P
G
L
--K
D
TPY
W
T
ST
E
AL
V
S
ET
I
P
K
RL
A
V
I
G
S
S
V
V
A
LE
L
A
QA
F
AR
LG
A
KV
T
IL
AR
S
T
LF
F-RE
D
PA
I
G
EA
V
TAA
F
RME
G
IE
V
R
E
H
T
Q
A
SQ
V
A
YI
N
GEG
DG
E
F
V
L
-
--
---
-
T
T
A
HG
E
L
R
A
D
K
LLVA
T
GR
A
PNT
RK
L
A
L
DAT
GV
T
L
TP
Q
G
A
I
V
I
D
PGM
RT
S
V
E
HIYA
A
GD
CTD
QP
QFV
Y
V
A
AA
A
G
T
R
AA
I
N
M
--
T
GG
D
A
AL
N
L
---
TA
M
P
A
V
VF
T
D
P
Q
VA
T
VG
Y
S
E
AE
A
HH
D
GI
K
T
D
S
R
T
LT
LD
NV
P
RA
L
A
N
F
DTR
G
FI
KL
V
V
EE
G
S
G
R
L
IG
VQA
V
A
PE
AGELI
Q
TA
A
LAI
R
N
---
R
M
T
V
QEL
A
D
Q
L
F
P
Y
L
T
M
V
E
GLK
LAA
QT
F
NKDVKQ
L
fig|749532.3.peg.3767
Escherichia coli MS 78-1 (75-535/540)
HI
A
VIGSG
G
A
AM
A
AA
L
K
A
V
E
QG
A
RV
T
L
I
ER
G
---
---
-
T
I
GG
T
C
V
NVGC
V
PSK
I
MI
R
AA
HI
A
H
L
RRES
P
F
DG
G
IAATT
P
TI
Q
R
T
A
L
L
AQ
Q
Q
A
R
V
DE
L
RH
A
K
YE
G
IL
E
GN
PA
I
T
VL
H
G
S
ARF
K
D
N
R
----
N
L
I
V
Q
L
N
DGG
ER
V
V
A
FD
R
C
L
IA
T
G
A
S
P
A
VPP
I
P
G
L
--K
D
TPY
W
T
ST
E
AL
V
S
ET
I
P
K
RL
A
V
I
G
S
S
V
V
A
LE
L
A
QA
F
AR
LG
A
KV
T
IL
AR
S
T
LF
F-RE
D
PA
I
G
EA
V
TAA
F
RME
G
IE
V
R
E
H
T
Q
A
SQ
V
A
YI
N
GEG
DG
E
F
V
L
-
--
---
-
T
T
A
HG
E
L
R
A
D
K
LLVA
T
GR
A
PNT
RK
L
A
L
DAT
GV
T
L
TP
Q
G
A
I
V
I
D
PGM
RT
S
V
E
HIYA
A
GD
CTD
QP
QFV
Y
V
A
AA
A
G
T
R
AA
I
N
M
--
T
GG
D
A
AL
N
L
---
TA
M
P
A
V
VF
T
D
P
Q
VA
T
VG
Y
S
E
AE
A
HH
D
GI
K
T
D
S
R
T
LT
LD
NV
P
RA
L
A
N
F
DTR
G
FI
KL
V
V
EE
G
S
G
R
L
IG
VQA
V
A
PE
AGELI
Q
TA
A
LAI
R
N
---
R
M
T
V
QEL
A
D
Q
L
F
P
Y
L
T
M
V
E
GLK
LAA
QT
F
NKDVKQ
L
fig|749533.3.peg.234
Escherichia coli MS 84-1 (75-535/540)
HI
A
VIGSG
G
A
AM
A
AA
L
K
A
V
E
QG
A
RV
T
L
I
ER
G
---
---
-
T
I
GG
T
C
V
NVGC
V
PSK
I
MI
R
AA
HI
A
H
L
RRES
P
F
DG
G
IAATT
P
TI
Q
R
T
A
L
L
AQ
Q
Q
A
R
V
DE
L
RH
A
K
YE
G
IL
E
GN
PA
I
T
VL
H
G
S
ARF
K
D
N
R
----
N
L
I
V
Q
L
N
DGG
ER
V
V
A
FD
R
C
L
IA
T
G
A
S
P
A
VPP
I
P
G
L
--K
D
TPY
W
T
ST
E
AL
V
S
ET
I
P
K
RL
A
V
I
G
S
S
V
V
A
LE
L
A
QA
F
AR
LG
A
KV
T
IL
AR
S
T
LF
F-RE
D
PA
I
G
EA
V
TAA
F
RME
G
IE
V
R
E
H
T
Q
A
SQ
V
A
YI
N
GEG
DG
E
F
V
L
-
--
---
-
T
T
A
HG
E
L
R
A
D
K
LLVA
T
GR
A
PNT
RK
L
A
L
DAT
GV
T
L
TP
Q
G
A
I
V
I
D
PGM
RT
S
V
E
HIYA
A
GD
CTD
QP
QFV
Y
V
A
AA
A
G
T
R
AA
I
N
M
--
T
GG
D
A
AL
N
L
---
TA
M
P
A
V
VF
T
D
P
Q
VA
T
VG
Y
S
E
AE
A
HH
D
GI
K
T
D
S
R
T
LT
LD
NV
P
RA
L
A
N
F
DTR
G
FI
KL
V
V
EE
G
S
G
R
L
IG
VQA
V
A
PE
AGELI
Q
TA
A
LAI
R
N
---
R
M
T
V
QEL
A
D
Q
L
F
P
Y
L
T
M
V
E
GLK
LAA
QT
F
NKDVKQ
L
fig|585396.4.peg.5587
Escherichia coli O111:H- str. 11128 (75-535/540)
HI
A
VIGSG
G
A
AM
A
AA
L
K
A
V
E
QG
A
RV
T
L
I
ER
G
---
---
-
T
I
GG
T
C
V
NVGC
V
PSK
I
MI
R
AA
HI
A
H
L
RRES
P
F
DG
G
IAATT
P
TI
Q
R
T
A
L
L
AQ
Q
Q
A
R
V
DE
L
RH
A
K
YE
G
IL
E
GN
PA
I
T
VL
H
G
S
ARF
K
D
N
R
----
N
L
I
V
Q
L
N
DGG
ER
V
V
A
FD
R
C
L
IA
T
G
A
S
P
A
VPP
I
P
G
L
--K
D
TPY
W
T
ST
E
AL
V
S
ET
I
P
K
RL
A
V
I
G
S
S
V
V
A
LE
L
A
QA
F
AR
LG
A
KV
T
IL
AR
S
T
LF
F-RE
D
PA
I
G
EA
V
TAA
F
RME
G
IE
V
R
E
H
T
Q
A
SQ
V
A
YI
N
GEG
DG
E
F
V
L
-
--
---
-
T
T
A
HG
E
L
R
A
D
K
LLVA
T
GR
A
PNT
RK
L
A
L
DAT
GV
T
L
TP
Q
G
A
I
V
I
D
PGM
RT
S
V
E
HIYA
A
GD
CTD
QP
QFV
Y
V
A
AA
A
G
T
R
AA
I
N
M
--
T
GG
D
A
AL
N
L
---
TA
M
P
A
V
VF
T
D
P
Q
VA
T
VG
Y
S
E
AE
A
HH
D
GI
K
T
D
S
R
T
LT
LD
NV
P
RA
L
A
N
F
DTR
G
FI
KL
V
V
EE
G
S
G
R
L
IG
VQA
V
A
PE
AGELI
Q
TA
A
LAI
R
N
---
R
M
T
V
QEL
A
D
Q
L
F
P
Y
L
T
M
V
E
GLK
LAA
QT
F
NKDVKQ
L
fig|685038.3.peg.4614
Escherichia coli O83:H1 str. NRG 857C (75-535/540)
HI
A
VIGSG
G
A
AM
A
AA
L
K
A
V
E
QG
A
RV
T
L
I
ER
G
---
---
-
T
I
GG
T
C
V
NVGC
V
PSK
I
MI
R
AA
HI
A
H
L
RRES
P
F
DG
G
IAATT
P
TI
Q
R
T
A
L
L
AQ
Q
Q
A
R
V
DE
L
RH
A
K
YE
G
IL
E
GN
PA
I
T
VL
H
G
S
ARF
K
D
N
R
----
N
L
I
V
Q
L
N
DGG
ER
V
V
A
FD
R
C
L
IA
T
G
A
S
P
A
VPP
I
P
G
L
--K
D
TPY
W
T
ST
E
AL
V
S
ET
I
P
K
RL
A
V
I
G
S
S
V
V
A
LE
L
A
QA
F
AR
LG
A
KV
T
IL
AR
S
T
LF
F-RE
D
PA
I
G
EA
V
TAA
F
RME
G
IE
V
R
E
H
T
Q
A
SQ
V
A
YI
N
GEG
DG
E
F
V
L
-
--
---
-
T
T
A
HG
E
L
R
A
D
K
LLVA
T
GR
A
PNT
RK
L
A
L
DAT
GV
T
L
TP
Q
G
A
I
V
I
D
PGM
RT
S
V
E
HIYA
A
GD
CTD
QP
QFV
Y
V
A
AA
A
G
T
R
AA
I
N
M
--
T
GG
D
A
AL
N
L
---
TA
M
P
A
V
VF
T
D
P
Q
VA
T
VG
Y
S
E
AE
A
HH
D
GI
K
T
D
S
R
T
LT
LD
NV
P
RA
L
A
N
F
DTR
G
FI
KL
V
V
EE
G
S
G
R
L
IG
VQA
V
A
PE
AGELI
Q
TA
A
LAI
R
N
---
R
M
T
V
QEL
A
D
Q
L
F
P
Y
L
T
M
V
E
GLK
LAA
QT
F
NKDVKQ
L
fig|344610.3.peg.2157
Escherichia coli 53638 (10-458/466)
I
VIGSGP
G
G
E
G
AA
M
G
L
V
K
QG
A
RV
A
V
I
------
ERY
Q
N
V
GG
G
C
THW
G
T
IPSKAL
R
HA
V
SR
I
I
E
FNQN
P
L
-
YS
DHSRL
L
RS
S
F
A
D
IL
NH
A
D
N
VINQ
Q
-
T
R
M
RQ
G
FY
ER
N
H
-
CEI
L
Q
G
N
ARF
V
D
E
H
----
TL
A
L
D
C
P
DG
S
VE
TL
T
AEK
F
VIA
C
GSRP
Y
--
HPT
D
V
DFT
H
PRI
Y
DS
D
S
I
L
S
M
HH
E
P
R
HV
L
I
Y
GAGVIG
C
E
Y
A
S
I
F
RG
MDV
KVDL
I
NT
R
D
RL
L
AF
LD
QE
M
S
DS
L
SYH
F
W
N
SG
VV
I
R
H
N
E
E
Y
E
KI
E
GC
D
---
DGV
I
M
H
L
KS
GKK
--
-
-
--
-
L
KA
D
C
LL
Y
A
N
GR
TG
NT
DS
L
A
L
QNI
G
L
E
T
D
S
RG
Q
L
K
V
N
IMY
Q
T
A
Q
PH
V
YA
V
GDV
I
G
Y
P
S
LA
SA
A
YD
Q
G
R
I
AA
Q
A
L
--
VK
G
E
A
TA
H
LI
--
ED
IP
T
G
IYT
I
PE
ISS
VG
K
TE
QQ
LT
A
M
KV
P
YE
V
G
R
AQ
F
K
HL
A
RA
Q
I
V
G
MNV
G
TL
K
I
L
F
HR
E
T
K
EIL
G
IHCF
G
ER
A
A
E
I
I
H
IG
Q
AIM
E
Q
KGG
G
N
T
I
E
YFV
N
T
TFNY
PT
M
A
E
AYR
V
AA
fig|344610.7.peg.2178
Escherichia coli 53638 (10-458/466)
I
VIGSGP
G
G
E
G
AA
M
G
L
V
K
QG
A
RV
A
V
I
------
ERY
Q
N
V
GG
G
C
THW
G
T
IPSKAL
R
HA
V
SR
I
I
E
FNQN
P
L
-
YS
DHSRL
L
RS
S
F
A
D
IL
NH
A
D
N
VINQ
Q
-
T
R
M
RQ
G
FY
ER
N
H
-
CEI
L
Q
G
N
ARF
V
D
E
H
----
TL
A
L
D
C
P
DG
S
VE
TL
T
AEK
F
VIA
C
GSRP
Y
--
HPT
D
V
DFT
H
PRI
Y
DS
D
S
I
L
S
M
HH
E
P
R
HV
L
I
Y
GAGVIG
C
E
Y
A
S
I
F
RG
MDV
KVDL
I
NT
R
D
RL
L
AF
LD
QE
M
S
DS
L
SYH
F
W
N
SG
VV
I
R
H
N
E
E
Y
E
KI
E
GC
D
---
DGV
I
M
H
L
KS
GKK
--
-
-
--
-
L
KA
D
C
LL
Y
A
N
GR
TG
NT
DS
L
A
L
QNI
G
L
E
T
D
S
RG
Q
L
K
V
N
IMY
Q
T
A
Q
PH
V
YA
V
GDV
I
G
Y
P
S
LA
SA
A
YD
Q
G
R
I
AA
Q
A
L
--
VK
G
E
A
TA
H
LI
--
ED
IP
T
G
IYT
I
PE
ISS
VG
K
TE
QQ
LT
A
M
KV
P
YE
V
G
R
AQ
F
K
HL
A
RA
Q
I
V
G
MNV
G
TL
K
I
L
F
HR
E
T
K
EIL
G
IHCF
G
ER
A
A
E
I
I
H
IG
Q
AIM
E
Q
KGG
G
N
T
I
E
YFV
N
T
TFNY
PT
M
A
E
AYR
V
AA
fig|749540.3.peg.1719
Escherichia coli MS 146-1 (10-458/466)
I
VIGSGP
G
G
E
G
AA
M
G
L
V
K
QG
A
RV
A
V
I
------
ERY
Q
N
V
GG
G
C
THW
G
T
IPSKAL
R
HA
V
SR
I
I
E
FNQN
P
L
-
YS
DHSRL
L
RS
S
F
A
D
IL
NH
A
D
N
VINQ
Q
-
T
R
M
RQ
G
FY
ER
N
H
-
CEI
L
Q
G
N
ARF
V
D
E
H
----
TL
A
L
D
C
P
DG
S
VE
TL
T
AEK
F
VIA
C
GSRP
Y
--
HPT
D
V
DFT
H
PRI
Y
DS
D
S
I
L
S
M
HH
E
P
R
HV
L
I
Y
GAGVIG
C
E
Y
A
S
I
F
RG
MDV
KVDL
I
NT
R
D
RL
L
AF
LD
QE
M
S
DS
L
SYH
F
W
N
SG
VV
I
R
H
N
E
E
Y
E
KI
E
GC
D
---
DGV
I
M
H
L
KS
GKK
--
-
-
--
-
L
KA
D
C
LL
Y
A
N
GR
TG
NT
DS
L
A
L
QNI
G
L
E
T
D
S
RG
Q
L
K
V
N
SMY
Q
T
A
Q
PH
V
YA
V
GDV
I
G
Y
P
S
LA
SA
A
YD
Q
G
R
I
AA
Q
A
L
--
VK
G
E
A
TA
H
LI
--
ED
IP
T
G
IYT
I
PE
ISS
VG
K
TE
QQ
LT
A
M
KV
P
YE
V
G
R
AQ
F
K
HL
A
RA
Q
I
V
G
MNV
G
TL
K
I
L
F
HR
E
T
K
EIL
G
IHCF
G
ER
A
A
E
I
I
H
IG
Q
AIM
E
Q
KGG
G
N
T
I
E
YFV
N
T
TFN
S
PT
M
A
E
AYR
V
AA
fig|562.371.peg.1837
Escherichia coli 1044A (10-458/466)
I
VIGSGP
G
G
E
G
AA
M
G
L
V
K
QG
A
RV
A
V
I
------
ERY
Q
N
V
GG
G
C
THW
G
T
IPSKAL
R
HA
V
SR
I
I
E
FNQN
P
L
-
YS
DHSRL
L
RS
S
F
A
D
IL
NH
A
D
N
VINQ
Q
-
T
R
M
RQ
G
FY
ER
N
H
-
CEI
L
Q
G
N
ARF
V
D
E
H
----
TL
A
L
D
C
P
DG
S
VE
TL
T
AEK
F
VIA
C
GSRP
Y
--
HPT
D
V
DFT
H
PRI
Y
DS
D
S
I
L
S
M
HH
E
P
R
HV
L
I
Y
GAGVIG
C
E
Y
A
S
I
F
RG
MDV
KVDL
I
NT
R
D
RL
L
AF
LD
QE
M
S
DS
L
SYH
F
W
N
SG
VV
I
R
H
N
E
E
Y
E
KI
E
GC
D
---
DGV
I
M
H
L
KS
GKK
--
-
-
--
-
L
KA
D
C
LL
Y
A
N
GR
TG
NT
DS
L
A
L
QNI
G
L
E
T
D
S
RG
Q
L
K
V
N
SMY
Q
T
A
Q
PH
V
YA
V
GDV
I
G
Y
P
S
LA
SA
A
YD
Q
G
R
I
AA
Q
A
L
--
VK
G
E
A
TA
H
LI
--
ED
IP
T
G
IYT
I
PE
ISS
VG
K
TE
QL
LT
A
M
KV
P
YE
V
G
R
AQ
F
K
HL
A
RA
Q
I
V
G
MNV
G
TL
K
I
L
F
HR
E
T
K
EIL
G
IHCF
G
ER
A
A
E
I
I
H
IG
Q
AIM
E
Q
KGG
G
N
T
I
E
YFV
N
T
TFNY
PT
M
A
E
AYR
V
AA
fig|155864.8.peg.4877
Escherichia coli O157:H7 EDL933 (10-458/466)
I
VIGSGP
G
G
E
G
AA
M
G
L
V
K
QG
A
RV
A
V
I
------
ERY
Q
N
V
GG
G
C
THW
G
T
IPSKAL
R
HA
V
SR
I
I
E
FNQN
P
L
-
YS
DHSRL
L
RS
S
F
A
D
IL
NH
A
D
N
VINQ
Q
-
T
R
M
RQ
G
FY
ER
N
H
-
CEI
L
Q
G
N
ARF
V
D
E
H
----
TL
A
L
D
C
P
DG
S
VE
TL
T
AEK
F
VIA
C
GSRP
Y
--
HPT
D
V
DFT
H
PRI
Y
DS
D
S
I
L
S
M
HH
E
P
R
HV
L
I
Y
GAGVIG
C
E
Y
A
S
I
F
RG
MDV
KVDL
I
NT
R
D
RL
L
AF
LD
QE
M
S
DS
L
SYH
F
W
N
SG
VV
I
R
H
N
E
E
Y
E
KI
E
GC
D
---
DGV
I
M
H
L
KS
GKK
--
-
-
--
-
L
KA
D
C
LL
Y
A
N
GR
TG
NT
DS
L
A
L
QNI
G
L
E
T
D
S
RG
Q
L
K
V
N
SMY
Q
T
A
Q
PH
V
YA
V
GDV
I
G
Y
P
S
LA
SA
A
YD
Q
G
R
I
AA
Q
A
L
--
VK
G
E
A
TA
H
LI
--
ED
IP
T
G
IYT
I
PE
ISS
VG
K
TE
QL
LT
A
M
KV
P
YE
V
G
R
AQ
F
K
HL
A
RA
Q
I
V
G
MNV
G
TL
K
I
L
F
HR
E
T
K
EIL
G
IHCF
G
ER
A
A
E
I
I
H
IG
Q
AIM
E
Q
KGG
G
N
T
I
E
YFV
N
T
TFNY
PT
M
A
E
AYR
V
AA
fig|478006.5.peg.2134
Escherichia coli O157:H7 str. EC4501 (10-458/466)
I
VIGSGP
G
G
E
G
AA
M
G
L
V
K
QG
A
RV
A
V
I
------
ERY
Q
N
V
GG
G
C
THW
G
T
IPSKAL
R
HA
V
SR
I
I
E
FNQN
P
L
-
YS
DHSRL
L
RS
S
F
A
D
IL
NH
A
D
N
VINQ
Q
-
T
R
M
RQ
G
FY
ER
N
H
-
CEI
L
Q
G
N
ARF
V
D
E
H
----
TL
A
L
D
C
P
DG
S
VE
TL
T
AEK
F
VIA
C
GSRP
Y
--
HPT
D
V
DFT
H
PRI
Y
DS
D
S
I
L
S
M
HH
E
P
R
HV
L
I
Y
GAGVIG
C
E
Y
A
S
I
F
RG
MDV
KVDL
I
NT
R
D
RL
L
AF
LD
QE
M
S
DS
L
SYH
F
W
N
SG
VV
I
R
H
N
E
E
Y
E
KI
E
GC
D
---
DGV
I
M
H
L
KS
GKK
--
-
-
--
-
L
KA
D
C
LL
Y
A
N
GR
TG
NT
DS
L
A
L
QNI
G
L
E
T
D
S
RG
Q
L
K
V
N
SMY
Q
T
A
Q
PH
V
YA
V
GDV
I
G
Y
P
S
LA
SA
A
YD
Q
G
R
I
AA
Q
A
L
--
VK
G
E
A
TA
H
LI
--
ED
IP
T
G
IYT
I
PE
ISS
VG
K
TE
QL
LT
A
M
KV
P
YE
V
G
R
AQ
F
K
HL
A
RA
Q
I
V
G
MNV
G
TL
K
I
L
F
HR
E
T
K
EIL
G
IHCF
G
ER
A
A
E
I
I
H
IG
Q
AIM
E
Q
KGG
G
N
T
I
E
YFV
N
T
TFNY
PT
M
A
E
AYR
V
AA
fig|386585.9.peg.5115
Escherichia coli O157:H7 str. Sakai (10-458/466)
I
VIGSGP
G
G
E
G
AA
M
G
L
V
K
QG
A
RV
A
V
I
------
ERY
Q
N
V
GG
G
C
THW
G
T
IPSKAL
R
HA
V
SR
I
I
E
FNQN
P
L
-
YS
DHSRL
L
RS
S
F
A
D
IL
NH
A
D
N
VINQ
Q
-
T
R
M
RQ
G
FY
ER
N
H
-
CEI
L
Q
G
N
ARF
V
D
E
H
----
TL
A
L
D
C
P
DG
S
VE
TL
T
AEK
F
VIA
C
GSRP
Y
--
HPT
D
V
DFT
H
PRI
Y
DS
D
S
I
L
S
M
HH
E
P
R
HV
L
I
Y
GAGVIG
C
E
Y
A
S
I
F
RG
MDV
KVDL
I
NT
R
D
RL
L
AF
LD
QE
M
S
DS
L
SYH
F
W
N
SG
VV
I
R
H
N
E
E
Y
E
KI
E
GC
D
---
DGV
I
M
H
L
KS
GKK
--
-
-
--
-
L
KA
D
C
LL
Y
A
N
GR
TG
NT
DS
L
A
L
QNI
G
L
E
T
D
S
RG
Q
L
K
V
N
SMY
Q
T
A
Q
PH
V
YA
V
GDV
I
G
Y
P
S
LA
SA
A
YD
Q
G
R
I
AA
Q
A
L
--
VK
G
E
A
TA
H
LI
--
ED
IP
T
G
IYT
I
PE
ISS
VG
K
TE
QL
LT
A
M
KV
P
YE
V
G
R
AQ
F
K
HL
A
RA
Q
I
V
G
MNV
G
TL
K
I
L
F
HR
E
T
K
EIL
G
IHCF
G
ER
A
A
E
I
I
H
IG
Q
AIM
E
Q
KGG
G
N
T
I
E
YFV
N
T
TFNY
PT
M
A
E
AYR
V
AA
fig|502346.5.peg.1704
Escherichia coli O157:H7 str. TW14588 (10-458/466)
I
VIGSGP
G
G
E
G
AA
M
G
L
V
K
QG
A
RV
A
V
I
------
ERY
Q
N
V
GG
G
C
THW
G
T
IPSKAL
R
HA
V
SR
I
I
E
FNQN
P
L
-
YS
DHSRL
L
RS
S
F
A
D
IL
NH
A
D
N
VINQ
Q
-
T
R
M
RQ
G
FY
ER
N
H
-
CEI
L
Q
G
N
ARF
V
D
E
H
----
TL
A
L
D
C
P
DG
S
VE
TL
T
AEK
F
VIA
C
GSRP
Y
--
HPT
D
V
DFT
H
PRI
Y
DS
D
S
I
L
S
M
HH
E
P
R
HV
L
I
Y
GAGVIG
C
E
Y
A
S
I
F
RG
MDV
KVDL
I
NT
R
D
RL
L
AF
LD
QE
M
S
DS
L
SYH
F
W
N
SG
VV
I
R
H
N
E
E
Y
E
KI
E
GC
D
---
DGV
I
M
H
L
KS
GKK
--
-
-
--
-
L
KA
D
C
LL
Y
A
N
GR
TG
NT
DS
L
A
L
QNI
G
L
E
T
D
S
RG
Q
L
K
V
N
SMY
Q
T
A
Q
PH
V
YA
V
GDV
I
G
Y
P
S
LA
SA
A
YD
Q
G
R
I
AA
Q
A
L
--
VK
G
E
A
TA
H
LI
--
ED
IP
T
G
IYT
I
PE
ISS
VG
K
TE
QL
LT
A
M
KV
P
YE
V
G
R
AQ
F
K
HL
A
RA
Q
I
V
G
MNV
G
TL
K
I
L
F
HR
E
T
K
EIL
G
IHCF
G
ER
A
A
E
I
I
H
IG
Q
AIM
E
Q
KGG
G
N
T
I
E
YFV
N
T
TFNY
PT
M
A
E
AYR
V
AA
fig|656414.3.peg.490
Escherichia coli H736 (3-435/441)
K
Y
Q
A
V
I
IG
F
G
K
AG
K
T
L
A
V
T
L
A
KA
G
W
RV
A
L
I
E
-----
Q
SN
A
MY
GG
T
C
I
N
I
GCIP
T
K
T
L
V
H
D
A
QQ
-
-
-
----
-
-
-
H
-
-----
-
-T
D
F
V
R
A
I
QR
K
N
E
V
V
N
F
L
RN
K
N
FH
N
LA
DMPN
-
I
D
V
I
D
G
Q
A
E
F
I
N
N
H
----
S
L
R
V
H
-
R
PE
G
NL
E
I
H
G
EK
I
F
I
N
T
G
A
Q
T
V
VPP
I
P
G
I
T-T
T
P
G
V
Y
DST
G
L
L
N
L
KE
L
P
G
H
L
GI
L
G
G
G
Y
IG
V
E
F
A
S
M
F
AN
F
GSKV
T
IL
E
A
A
S
LF
LP
RE
D
RD
I
A
DN
I
ATI
LRDQ
G
VD
I
I
L
N
AH
V
E
R
I
S
HH
E
---
N
Q
V
Q
V
H
-
--
---
--
S
E
HA
Q
L
AV
D
A
LL
I
A
S
GR
Q
P
A
T
AS
L
HP
ENA
G
I
A
V
NE
RG
A
I
V
VD
KRL
H
T
T
A
D
N
I
W
A
M
GDV
T
G
GLQFT
Y
I
S
LD
D
Y
R
I
VR
D
E
L
LGE
G
K
RS
TD
D
R
---
KN
V
P
Y
S
VF
M
T
P
P
L
S
R
VG
M
TE
EQ
A
R
E
S
G
A
D
I
Q
V
V
T
LP
V
A
AI
P
RA
R
V
M
N
DTR
G
VL
K
A
I
V
D
N
K
T
Q
R
M
L
G
A
SLL
C
VD
S
H
E
M
I
N
I
V
K
M
V
M
D
A
---
G
L
P
Y
SI
L
R
D
Q
I
F
T
HP
S
M
S
E
SLN
V
fig|749540.3.peg.249
Escherichia coli MS 146-1 (3-435/441)
K
Y
Q
A
V
I
IG
F
G
K
AG
K
T
L
A
V
T
L
A
KA
G
W
RV
A
L
I
E
-----
Q
SN
A
MY
GG
T
C
I
N
I
GCIP
T
K
T
L
V
H
D
A
QQ
-
-
-
----
-
-
-
H
-
-----
-
-T
D
F
V
R
A
I
QR
K
N
E
V
V
N
F
L
RN
K
N
FH
N
LA
DMPN
-
I
D
V
I
D
G
Q
A
E
F
I
N
N
H
----
S
L
R
V
H
-
R
PE
G
NL
E
I
H
G
EK
I
F
I
N
T
G
A
Q
T
V
VPP
I
P
G
I
T-T
T
P
G
V
Y
DST
G
L
L
N
L
KE
L
P
G
H
L
GI
L
G
G
G
Y
IG
V
E
F
A
S
M
F
AN
F
GSKV
T
IL
E
A
A
S
LF
LP
RE
D
RD
I
A
DN
I
ATI
LRDQ
G
VD
I
I
L
N
AH
V
E
R
I
S
HH
E
---
N
Q
V
Q
V
H
-
--
---
--
S
E
HA
Q
L
AV
D
A
LL
I
A
S
GR
Q
P
A
T
AS
L
HP
ENA
G
I
A
V
NE
RG
A
I
V
VD
KRL
H
T
T
A
D
N
I
W
A
M
GDV
T
G
GLQFT
Y
I
S
LD
D
Y
R
I
VR
D
E
L
LGE
G
K
RS
TD
D
R
---
KN
V
P
Y
S
VF
M
T
P
P
L
S
R
VG
M
TE
EQ
A
R
E
S
G
A
D
I
Q
V
V
T
LP
V
A
AI
P
RA
R
V
M
N
DTR
G
VL
K
A
I
V
D
N
K
T
Q
R
M
L
G
A
SLL
C
VD
S
H
E
M
I
N
I
V
K
M
V
M
D
A
---
G
L
P
Y
SI
L
R
D
Q
I
F
T
HP
S
M
S
E
SLN
V
Consen1
Primary consensus
MTAGDKYIEVMMSTEIKTqv
ViGsGPaGy
AA
r
adqGlrvvii
------
ery
tlGG
ClnvGcIPSKaLlhaa
i
e
a
-
hg
p
d
a
il
kd
vinql
-
T
g
G
kgnk
-
vkvl
GlarF
da
----
tL
ve
-
dgg
vi
fdn
vIA
GSrP
--
qlp
v
dprIwDSt
aL
l
vPerllv
GaGvIGlE
gsvf
lgskvdlvem
d
lpalD
is
v
fissg
l
l
te
eavE
d
---
DGv
v
-
GkK
--
e
rl
--
D
lLvAiGRvpNt
Ldl
GvE
DdRG
i
Vd
rTn
pHiyAiGDvvgqPmLAhka
eG
vAAe
i
--
aggka
dp
---
IPs
iYT
PEvawVG
tE
aka
gi
ye
gt
fa
gRA
a
g
G
Klifdkes
rviGgaivG
agEli
ei
laie
---
g
t
Edia
tihahPTl
E
lAAevFegsitdLPNPKAKKK
Consen2
Secondary consensus
hi
l
a
g
e
g
v
l
aeta
vddg
qge
n
thw
t
s
rqvv
y
q
p
iys
l
d
mr
ae
ivsrq
m
errh
ceiv
ngk
ge
q
l
c
ens
tl
aek
i
q
hpt
i
qq
y
d
i
m
e
hvgi
g
i
c
atiy
mdvqitv
nt
p
iafa
mv
l
rw
kk
h
ek
tki
e
i
m
l
e
ap
-
-
yka
v
y
n
tg
g
aa
l
l
n
q
a
vf
v
iiry
s
sag
q
i
l
vkk
h
li
t
a
iss
n
lte
kv
fn
ar
wk
a
i
d
i
shrht
eil
ihcf
ga
il
ig
aimt
kggs
d
yfv
atfny
m
v
qt
nkdvkq
Consensus 1
(when a gap)
Conservative difference
Consensus 2
(when a gap)
Nonconservative diff.
Other character