fig|1040638.4.peg.5638
Escherichia coli O104:H4 str. LB226692
MV
V
RS
L
IDQ
GV
KQ
V
F
G
YP
G
GA
V
LD
I
Y
D
A
L
HTV
-
G
G
I
D
H
V
LV
RHEQ
A
A
VHM
A
D
G
L
A
RAT
G
E
V
GV
--
V
LVT
SGPG
A
TN
A
ITG
I
A
T
A
YM
D
SI
PL
V
V
L
SG
QVATSL
IG
--
Y
D
A
FQE
C
D
MV
--------
GISRPVV
K
HSF
LV
KQT
ED
I
P
QV
L
KK
A
FWL
A
A
S
-
GRPG
P
V
V
VDLP
K
D
I
LNPANKLP
YVW
PESVSMRSYNPT-
-
-TTGHKGQ
I
KR
A
LQT
L
VA
A
KK
P
V
V
YV
G
G
G
AIM
A
G
C
HQQ
L
K
E
TVEALNL
P
VVSS
L
M
GLG
AF
P
AT
H
R
QAL
GM
L
GM
H
G
TYEANMT
M
H
NAD
V
I
FA
VG
V
RF
DD
R
TTNNLAK
Y
C
P
-
NA
TV
L
HIDIDP
T
S
I
SKTVTAD
I
P
IVGD
ARQV
L
EQ
M
L
EL
L
SQESAHQ
PL
D
EI
RD
W
W
Q
QIEQW
R
ARQCLKYD--THS
E
----------------------------
K
-
IKPQAVIET
L
WR
----
LTKGDAYV
T
S
DVG
QH
QM
F
AA
LY
-
YPFDK
PR
RW
I
N
S
G
--------
GL
G
T
MG
F
GLP
A
A
L
G
V
KM
A
L
P
EET
VVC
VT
GDG
SIQ
M
NIQ
E
LS
T
AL
Q
YE
LPV
L
V
V
NL
NN
RY
LG
M
V
K
-
QWQD
M
IYSGRHSQSYMQSL
-----------
PD
F
VR
LA
E
A
Y
G
HV
G
IQ
I
SHPH
E
LES
K
L
SEALEQ
V
C
N
NR
L
VF
V
D
V
T
V
D
GS
--------
E
HVY
P
M
Q
IR
G
G
G
M
D
EMWLSKTERT
fig|6666666.5357.peg.1772
Escherichia coli TY-2482 (9-574/574)
MV
V
RS
L
IDQ
GV
KQ
V
F
G
YP
G
GA
V
LD
I
Y
D
A
L
HTV
-
G
G
I
D
H
V
LV
RHEQ
A
A
VHM
A
D
G
L
A
RAT
G
E
V
GV
--
V
LVT
SGPG
A
TN
A
ITG
I
A
T
A
YM
D
SI
PL
V
V
L
SG
QVATSL
IG
--
Y
D
A
FQE
C
D
MV
--------
GISRPVV
K
HSF
LV
KQT
ED
I
P
QV
L
KK
A
FWL
A
A
S
-
GRPG
P
V
V
VDLP
K
D
I
LNPANKLP
YVW
PESVSMRSYNPT-
-
-TTGHKGQ
I
KR
A
LQT
L
VA
A
KK
P
V
V
YV
G
G
G
AIM
A
G
C
HQQ
L
K
E
TVEALNL
P
VVSS
L
M
GLG
AF
P
AT
H
R
QAL
GM
L
GM
H
G
TYEANMT
M
H
NAD
V
I
FA
VG
V
RF
DD
R
TTNNLAK
Y
C
P
-
NA
TV
L
HIDIDP
T
S
I
SKTVTAD
I
P
IVGD
ARQV
L
EQ
M
L
EL
L
SQESAHQ
PL
D
EI
RD
W
W
Q
QIEQW
R
ARQCLKYD--THS
E
----------------------------
K
-
IKPQAVIET
L
WR
----
LTKGDAYV
T
S
DVG
QH
QM
F
AA
LY
-
YPFDK
PR
RW
I
N
S
G
--------
GL
G
T
MG
F
GLP
A
A
L
G
V
KM
A
L
P
EET
VVC
VT
GDG
SIQ
M
NIQ
E
LS
T
AL
Q
YE
LPV
L
V
V
NL
NN
RY
LG
M
V
K
-
QWQD
M
IYSGRHSQSYMQSL
-----------
PD
F
VR
LA
E
A
Y
G
HV
G
IQ
I
SHPH
E
LES
K
L
SEALEQ
V
C
N
NR
L
VF
V
D
V
T
V
D
GS
--------
E
HVY
P
M
Q
IR
G
G
G
M
D
EMWLSKTERT
fig|585055.6.peg.80
Escherichia coli 55989
MV
V
RS
L
IDQ
GV
KQ
V
F
G
YP
G
GA
V
LD
I
Y
D
A
L
HTV
-
G
G
I
D
H
V
LV
RHEQ
A
A
VHM
A
D
G
L
A
RAT
G
E
V
GV
--
V
LVT
SGPG
A
TN
A
ITG
I
A
T
A
YM
D
SI
PL
V
V
L
SG
QVATSL
IG
--
Y
D
A
FQE
C
D
MV
--------
GISRPVV
K
HSF
LV
KQT
ED
I
P
QV
L
KK
A
FWL
A
A
S
-
GRPG
P
V
V
VDLP
K
D
I
LNPANKLP
YVW
PESVSMRSYNPT-
-
-TTGHKGQ
I
KR
A
LQT
L
VA
A
KK
P
V
V
YV
G
G
G
AIM
A
G
C
HQQ
L
K
E
TVEALNL
P
VVSS
L
M
GLG
AF
P
AT
H
R
QAL
GM
L
GM
H
G
TYEANMT
M
H
NAD
V
I
FA
VG
V
RF
DD
R
TTNNLAK
Y
C
P
-
NA
TV
L
HIDIDP
T
S
I
SKTVTAD
I
P
IVGD
ARQV
L
EQ
M
L
EL
L
SQESAHQ
PL
D
EI
RD
W
W
Q
QIEQW
R
ARQCLKYD--THS
E
----------------------------
K
-
IKPQAVIET
L
WR
----
LTKGDAYV
T
S
DVG
QH
QM
F
AA
LY
-
YPFDK
PR
RW
I
N
S
G
--------
GL
G
T
MG
F
GLP
A
A
L
G
V
KM
A
L
P
EET
VVC
VT
GDG
SIQ
M
NIQ
E
LS
T
AL
Q
YE
LPV
L
V
V
NL
NN
RY
LG
M
V
K
-
QWQD
M
IYSGRHSQSYMQSL
-----------
PD
F
VR
LA
E
A
Y
G
HV
G
IQ
I
SHPH
E
LES
K
L
SEALEQ
V
C
N
NR
L
VF
V
D
V
T
V
D
GS
--------
E
HVY
P
M
Q
IR
G
G
G
M
D
EMWLSKTERT
fig|585055.8.peg.80
Escherichia coli 55989
MV
V
RS
L
IDQ
GV
KQ
V
F
G
YP
G
GA
V
LD
I
Y
D
A
L
HTV
-
G
G
I
D
H
V
LV
RHEQ
A
A
VHM
A
D
G
L
A
RAT
G
E
V
GV
--
V
LVT
SGPG
A
TN
A
ITG
I
A
T
A
YM
D
SI
PL
V
V
L
SG
QVATSL
IG
--
Y
D
A
FQE
C
D
MV
--------
GISRPVV
K
HSF
LV
KQT
ED
I
P
QV
L
KK
A
FWL
A
A
S
-
GRPG
P
V
V
VDLP
K
D
I
LNPANKLP
YVW
PESVSMRSYNPT-
-
-TTGHKGQ
I
KR
A
LQT
L
VA
A
KK
P
V
V
YV
G
G
G
AIM
A
G
C
HQQ
L
K
E
TVEALNL
P
VVSS
L
M
GLG
AF
P
AT
H
R
QAL
GM
L
GM
H
G
TYEANMT
M
H
NAD
V
I
FA
VG
V
RF
DD
R
TTNNLAK
Y
C
P
-
NA
TV
L
HIDIDP
T
S
I
SKTVTAD
I
P
IVGD
ARQV
L
EQ
M
L
EL
L
SQESAHQ
PL
D
EI
RD
W
W
Q
QIEQW
R
ARQCLKYD--THS
E
----------------------------
K
-
IKPQAVIET
L
WR
----
LTKGDAYV
T
S
DVG
QH
QM
F
AA
LY
-
YPFDK
PR
RW
I
N
S
G
--------
GL
G
T
MG
F
GLP
A
A
L
G
V
KM
A
L
P
EET
VVC
VT
GDG
SIQ
M
NIQ
E
LS
T
AL
Q
YE
LPV
L
V
V
NL
NN
RY
LG
M
V
K
-
QWQD
M
IYSGRHSQSYMQSL
-----------
PD
F
VR
LA
E
A
Y
G
HV
G
IQ
I
SHPH
E
LES
K
L
SEALEQ
V
C
N
NR
L
VF
V
D
V
T
V
D
GS
--------
E
HVY
P
M
Q
IR
G
G
G
M
D
EMWLSKTERT
fig|340185.3.peg.4255
Escherichia coli E22 (37-602/602)
MV
V
RS
L
IDQ
GV
KQ
V
F
G
YP
G
GA
V
LD
I
Y
D
A
L
HTV
-
G
G
I
D
H
V
LV
RHEQ
A
A
VHM
A
D
G
L
A
RAT
G
E
V
GV
--
V
LVT
SGPG
A
TN
A
ITG
I
A
T
A
YM
D
SI
PL
V
V
L
SG
QVATSL
IG
--
Y
D
A
FQE
C
D
MV
--------
GISRPVV
K
HSF
LV
KQT
ED
I
P
QV
L
KK
A
FWL
A
A
S
-
GRPG
P
V
V
VDLP
K
D
I
LNPANKLP
YVW
PESVSMRSYNPT-
-
-TTGHKGQ
I
KR
A
LQT
L
VA
A
KK
P
V
V
YV
G
G
G
AIM
A
G
C
HQQ
L
K
E
TVEALNL
P
VVSS
L
M
GLG
AF
P
AT
H
R
QAL
GM
L
GM
H
G
TYEANMT
M
H
NAD
V
I
FA
VG
V
RF
DD
R
TTNNLAK
Y
C
P
-
NA
TV
L
HIDIDP
T
S
I
SKTVTAD
I
P
IVGD
ARQV
L
EQ
M
L
EL
L
SQESAHQ
PL
D
EI
RD
W
W
Q
QIEQW
R
ARQCLKYD--THS
E
----------------------------
K
-
IKPQAVIET
L
WR
----
LTKGDAYV
T
S
DVG
QH
QM
F
AA
LY
-
YPFDK
PR
RW
I
N
S
G
--------
GL
G
T
MG
F
GLP
A
A
L
G
V
KM
A
L
P
EET
VVC
VT
GDG
SIQ
M
NIQ
E
LS
T
AL
Q
YE
LPV
L
V
V
NL
NN
RY
LG
M
V
K
-
QWQD
M
IYSGRHSQSYMQSL
-----------
PD
F
VR
LA
E
A
Y
G
HV
G
IQ
I
SHPH
E
LES
K
L
SEALEQ
V
C
N
NR
L
VF
V
D
V
T
V
D
GS
--------
E
HVY
P
M
Q
IR
G
G
G
M
D
EMWLSKTERT
fig|340185.4.peg.4488
Escherichia coli E22
MV
V
RS
L
IDQ
GV
KQ
V
F
G
YP
G
GA
V
LD
I
Y
D
A
L
HTV
-
G
G
I
D
H
V
LV
RHEQ
A
A
VHM
A
D
G
L
A
RAT
G
E
V
GV
--
V
LVT
SGPG
A
TN
A
ITG
I
A
T
A
YM
D
SI
PL
V
V
L
SG
QVATSL
IG
--
Y
D
A
FQE
C
D
MV
--------
GISRPVV
K
HSF
LV
KQT
ED
I
P
QV
L
KK
A
FWL
A
A
S
-
GRPG
P
V
V
VDLP
K
D
I
LNPANKLP
YVW
PESVSMRSYNPT-
-
-TTGHKGQ
I
KR
A
LQT
L
VA
A
KK
P
V
V
YV
G
G
G
AIM
A
G
C
HQQ
L
K
E
TVEALNL
P
VVSS
L
M
GLG
AF
P
AT
H
R
QAL
GM
L
GM
H
G
TYEANMT
M
H
NAD
V
I
FA
VG
V
RF
DD
R
TTNNLAK
Y
C
P
-
NA
TV
L
HIDIDP
T
S
I
SKTVTAD
I
P
IVGD
ARQV
L
EQ
M
L
EL
L
SQESAHQ
PL
D
EI
RD
W
W
Q
QIEQW
R
ARQCLKYD--THS
E
----------------------------
K
-
IKPQAVIET
L
WR
----
LTKGDAYV
T
S
DVG
QH
QM
F
AA
LY
-
YPFDK
PR
RW
I
N
S
G
--------
GL
G
T
MG
F
GLP
A
A
L
G
V
KM
A
L
P
EET
VVC
VT
GDG
SIQ
M
NIQ
E
LS
T
AL
Q
YE
LPV
L
V
V
NL
NN
RY
LG
M
V
K
-
QWQD
M
IYSGRHSQSYMQSL
-----------
PD
F
VR
LA
E
A
Y
G
HV
G
IQ
I
SHPH
E
LES
K
L
SEALEQ
V
C
N
NR
L
VF
V
D
V
T
V
D
GS
--------
E
HVY
P
M
Q
IR
G
G
G
M
D
EMWLSKTERT
fig|562.375.peg.2575
Escherichia coli EC4100B
MV
V
RS
L
IDQ
GV
KQ
V
F
G
YP
G
GA
V
LD
I
Y
D
A
L
HTV
-
G
G
I
D
H
V
LV
RHEQ
A
A
VHM
A
D
G
L
A
RAT
G
E
V
GV
--
V
LVT
SGPG
A
TN
A
ITG
I
A
T
A
YM
D
SI
PL
V
V
L
SG
QVATSL
IG
--
Y
D
A
FQE
C
D
MV
--------
GISRPVV
K
HSF
LV
KQT
ED
I
P
QV
L
KK
A
FWL
A
A
S
-
GRPG
P
V
V
VDLP
K
D
I
LNPANKLP
YVW
PESVSMRSYNPT-
-
-TTGHKGQ
I
KR
A
LQT
L
VA
A
KK
P
V
V
YV
G
G
G
AIM
A
G
C
HQQ
L
K
E
TVEALNL
P
VVSS
L
M
GLG
AF
P
AT
H
R
QAL
GM
L
GM
H
G
TYEANMT
M
H
NAD
V
I
FA
VG
V
RF
DD
R
TTNNLAK
Y
C
P
-
NA
TV
L
HIDIDP
T
S
I
SKTVTAD
I
P
IVGD
ARQV
L
EQ
M
L
EL
L
SQESAHQ
PL
D
EI
RD
W
W
Q
QIEQW
R
ARQCLKYD--THS
E
----------------------------
K
-
IKPQAVIET
L
WR
----
LTKGDAYV
T
S
DVG
QH
QM
F
AA
LY
-
YPFDK
PR
RW
I
N
S
G
--------
GL
G
T
MG
F
GLP
A
A
L
G
V
KM
A
L
P
EET
VVC
VT
GDG
SIQ
M
NIQ
E
LS
T
AL
Q
YE
LPV
L
V
V
NL
NN
RY
LG
M
V
K
-
QWQD
M
IYSGRHSQSYMQSL
-----------
PD
F
VR
LA
E
A
Y
G
HV
G
IQ
I
SHPH
E
LES
K
L
SEALEQ
V
C
N
NR
L
VF
V
D
V
T
V
D
GS
--------
E
HVY
P
M
Q
IR
G
G
G
M
D
EMWLSKTERT
fig|331112.3.peg.78
Escherichia coli HS (37-602/602)
MV
V
RS
L
IDQ
GV
KQ
V
F
G
YP
G
GA
V
LD
I
Y
D
A
L
HTV
-
G
G
I
D
H
V
LV
RHEQ
A
A
VHM
A
D
G
L
A
RAT
G
E
V
GV
--
V
LVT
SGPG
A
TN
A
ITG
I
A
T
A
YM
D
SI
PL
V
V
L
SG
QVATSL
IG
--
Y
D
A
FQE
C
D
MV
--------
GISRPVV
K
HSF
LV
KQT
ED
I
P
QV
L
KK
A
FWL
A
A
S
-
GRPG
P
V
V
VDLP
K
D
I
LNPANKLP
YVW
PESVSMRSYNPT-
-
-TTGHKGQ
I
KR
A
LQT
L
VA
A
KK
P
V
V
YV
G
G
G
AIM
A
G
C
HQQ
L
K
E
TVEALNL
P
VVSS
L
M
GLG
AF
P
AT
H
R
QAL
GM
L
GM
H
G
TYEANMT
M
H
NAD
V
I
FA
VG
V
RF
DD
R
TTNNLAK
Y
C
P
-
NA
TV
L
HIDIDP
T
S
I
SKTVTAD
I
P
IVGD
ARQV
L
EQ
M
L
EL
L
SQESAHQ
PL
D
EI
RD
W
W
Q
QIEQW
R
ARQCLKYD--THS
E
----------------------------
K
-
IKPQAVIET
L
WR
----
LTKGDAYV
T
S
DVG
QH
QM
F
AA
LY
-
YPFDK
PR
RW
I
N
S
G
--------
GL
G
T
MG
F
GLP
A
A
L
G
V
KM
A
L
P
EET
VVC
VT
GDG
SIQ
M
NIQ
E
LS
T
AL
Q
YE
LPV
L
V
V
NL
NN
RY
LG
M
V
K
-
QWQD
M
IYSGRHSQSYMQSL
-----------
PD
F
VR
LA
E
A
Y
G
HV
G
IQ
I
SHPH
E
LES
K
L
SEALEQ
V
C
N
NR
L
VF
V
D
V
T
V
D
GS
--------
E
HVY
P
M
Q
IR
G
G
G
M
D
EMWLSKTERT
fig|331112.6.peg.83
Escherichia coli HS
MV
V
RS
L
IDQ
GV
KQ
V
F
G
YP
G
GA
V
LD
I
Y
D
A
L
HTV
-
G
G
I
D
H
V
LV
RHEQ
A
A
VHM
A
D
G
L
A
RAT
G
E
V
GV
--
V
LVT
SGPG
A
TN
A
ITG
I
A
T
A
YM
D
SI
PL
V
V
L
SG
QVATSL
IG
--
Y
D
A
FQE
C
D
MV
--------
GISRPVV
K
HSF
LV
KQT
ED
I
P
QV
L
KK
A
FWL
A
A
S
-
GRPG
P
V
V
VDLP
K
D
I
LNPANKLP
YVW
PESVSMRSYNPT-
-
-TTGHKGQ
I
KR
A
LQT
L
VA
A
KK
P
V
V
YV
G
G
G
AIM
A
G
C
HQQ
L
K
E
TVEALNL
P
VVSS
L
M
GLG
AF
P
AT
H
R
QAL
GM
L
GM
H
G
TYEANMT
M
H
NAD
V
I
FA
VG
V
RF
DD
R
TTNNLAK
Y
C
P
-
NA
TV
L
HIDIDP
T
S
I
SKTVTAD
I
P
IVGD
ARQV
L
EQ
M
L
EL
L
SQESAHQ
PL
D
EI
RD
W
W
Q
QIEQW
R
ARQCLKYD--THS
E
----------------------------
K
-
IKPQAVIET
L
WR
----
LTKGDAYV
T
S
DVG
QH
QM
F
AA
LY
-
YPFDK
PR
RW
I
N
S
G
--------
GL
G
T
MG
F
GLP
A
A
L
G
V
KM
A
L
P
EET
VVC
VT
GDG
SIQ
M
NIQ
E
LS
T
AL
Q
YE
LPV
L
V
V
NL
NN
RY
LG
M
V
K
-
QWQD
M
IYSGRHSQSYMQSL
-----------
PD
F
VR
LA
E
A
Y
G
HV
G
IQ
I
SHPH
E
LES
K
L
SEALEQ
V
C
N
NR
L
VF
V
D
V
T
V
D
GS
--------
E
HVY
P
M
Q
IR
G
G
G
M
D
EMWLSKTERT
fig|679205.4.peg.2337
Escherichia coli MS 124-1
MV
V
RS
L
IDQ
GV
KQ
V
F
G
YP
G
GA
V
LD
I
Y
D
A
L
HTV
-
G
G
I
D
H
V
LV
RHEQ
A
A
VHM
A
D
G
L
A
RAT
G
E
V
GV
--
V
LVT
SGPG
A
TN
A
ITG
I
A
T
A
YM
D
SI
PL
V
V
L
SG
QVATSL
IG
--
Y
D
A
FQE
C
D
MV
--------
GISRPVV
K
HSF
LV
KQT
ED
I
P
QV
L
KK
A
FWL
A
A
S
-
GRPG
P
V
V
VDLP
K
D
I
LNPANKLP
YVW
PESVSMRSYNPT-
-
-TTGHKGQ
I
KR
A
LQT
L
VA
A
KK
P
V
V
YV
G
G
G
AIM
A
G
C
HQQ
L
K
E
TVEALNL
P
VVSS
L
M
GLG
AF
P
AT
H
R
QAL
GM
L
GM
H
G
TYEANMT
M
H
NAD
V
I
FA
VG
V
RF
DD
R
TTNNLAK
Y
C
P
-
NA
TV
L
HIDIDP
T
S
I
SKTVTAD
I
P
IVGD
ARQV
L
EQ
M
L
EL
L
SQESAHQ
PL
D
EI
RD
W
W
Q
QIEQW
R
ARQCLKYD--THS
E
----------------------------
K
-
IKPQAVIET
L
WR
----
LTKGDAYV
T
S
DVG
QH
QM
F
AA
LY
-
YPFDK
PR
RW
I
N
S
G
--------
GL
G
T
MG
F
GLP
A
A
L
G
V
KM
A
L
P
EET
VVC
VT
GDG
SIQ
M
NIQ
E
LS
T
AL
Q
YE
LPV
L
V
V
NL
NN
RY
LG
M
V
K
-
QWQD
M
IYSGRHSQSYMQSL
-----------
PD
F
VR
LA
E
A
Y
G
HV
G
IQ
I
SHPH
E
LES
K
L
SEALEQ
V
C
N
NR
L
VF
V
D
V
T
V
D
GS
--------
E
HVY
P
M
Q
IR
G
G
G
M
D
EMWLSKTERT
fig|749533.3.peg.3361
Escherichia coli MS 84-1
MV
V
RS
L
IDQ
GV
KQ
V
F
G
YP
G
GA
V
LD
I
Y
D
A
L
HTV
-
G
G
I
D
H
V
LV
RHEQ
A
A
VHM
A
D
G
L
A
RAT
G
E
V
GV
--
V
LVT
SGPG
A
TN
A
ITG
I
A
T
A
YM
D
SI
PL
V
V
L
SG
QVATSL
IG
--
Y
D
A
FQE
C
D
MV
--------
GISRPVV
K
HSF
LV
KQT
ED
I
P
QV
L
KK
A
FWL
A
A
S
-
GRPG
P
V
V
VDLP
K
D
I
LNPANKLP
YVW
PESVSMRSYNPT-
-
-TTGHKGQ
I
KR
A
LQT
L
VA
A
KK
P
V
V
YV
G
G
G
AIM
A
G
C
HQQ
L
K
E
TVEALNL
P
VVSS
L
M
GLG
AF
P
AT
H
R
QAL
GM
L
GM
H
G
TYEANMT
M
H
NAD
V
I
FA
VG
V
RF
DD
R
TTNNLAK
Y
C
P
-
NA
TV
L
HIDIDP
T
S
I
SKTVTAD
I
P
IVGD
ARQV
L
EQ
M
L
EL
L
SQESAHQ
PL
D
EI
RD
W
W
Q
QIEQW
R
ARQCLKYD--THS
E
----------------------------
K
-
IKPQAVIET
L
WR
----
LTKGDAYV
T
S
DVG
QH
QM
F
AA
LY
-
YPFDK
PR
RW
I
N
S
G
--------
GL
G
T
MG
F
GLP
A
A
L
G
V
KM
A
L
P
EET
VVC
VT
GDG
SIQ
M
NIQ
E
LS
T
AL
Q
YE
LPV
L
V
V
NL
NN
RY
LG
M
V
K
-
QWQD
M
IYSGRHSQSYMQSL
-----------
PD
F
VR
LA
E
A
Y
G
HV
G
IQ
I
SHPH
E
LES
K
L
SEALEQ
V
C
N
NR
L
VF
V
D
V
T
V
D
GS
--------
E
HVY
P
M
Q
IR
G
G
G
M
D
EMWLSKTERT
fig|585395.4.peg.79
Escherichia coli O103:H2 str. 12009
MV
V
RS
L
IDQ
GV
KQ
V
F
G
YP
G
GA
V
LD
I
Y
D
A
L
HTV
-
G
G
I
D
H
V
LV
RHEQ
A
A
VHM
A
D
G
L
A
RAT
G
E
V
GV
--
V
LVT
SGPG
A
TN
A
ITG
I
A
T
A
YM
D
SI
PL
V
V
L
SG
QVATSL
IG
--
Y
D
A
FQE
C
D
MV
--------
GISRPVV
K
HSF
LV
KQT
ED
I
P
QV
L
KK
A
FWL
A
A
S
-
GRPG
P
V
V
VDLP
K
D
I
LNPANKLP
YVW
PESVSMRSYNPT-
-
-TTGHKGQ
I
KR
A
LQT
L
VA
A
KK
P
V
V
YV
G
G
G
AIM
A
G
C
HQQ
L
K
E
TVEALNL
P
VVSS
L
M
GLG
AF
P
AT
H
R
QAL
GM
L
GM
H
G
TYEANMT
M
H
NAD
V
I
FA
VG
V
RF
DD
R
TTNNLAK
Y
C
P
-
NA
TV
L
HIDIDP
T
S
I
SKTVTAD
I
P
IVGD
ARQV
L
EQ
M
L
EL
L
SQESAHQ
PL
D
EI
RD
W
W
Q
QIEQW
R
ARQCLKYD--THS
E
----------------------------
K
-
IKPQAVIET
L
WR
----
LTKGDAYV
T
S
DVG
QH
QM
F
AA
LY
-
YPFDK
PR
RW
I
N
S
G
--------
GL
G
T
MG
F
GLP
A
A
L
G
V
KM
A
L
P
EET
VVC
VT
GDG
SIQ
M
NIQ
E
LS
T
AL
Q
YE
LPV
L
V
V
NL
NN
RY
LG
M
V
K
-
QWQD
M
IYSGRHSQSYMQSL
-----------
PD
F
VR
LA
E
A
Y
G
HV
G
IQ
I
SHPH
E
LES
K
L
SEALEQ
V
C
N
NR
L
VF
V
D
V
T
V
D
GS
--------
E
HVY
P
M
Q
IR
G
G
G
M
D
EMWLSKTERT
fig|585396.4.peg.80
Escherichia coli O111:H- str. 11128 (9-574/574)
MV
V
RS
L
IDQ
GV
KQ
V
F
G
YP
G
GA
V
LD
I
Y
D
A
L
HTV
-
G
G
I
D
H
V
LV
RHEQ
A
A
VHM
A
D
G
L
A
RAT
G
E
V
GV
--
V
LVT
SGPG
A
TN
A
ITG
I
A
T
A
YM
D
SI
PL
V
V
L
SG
QVATSL
IG
--
Y
D
A
FQE
C
D
MV
--------
GISRPVV
K
HSF
LV
KQT
ED
I
P
QV
L
KK
A
FWL
A
A
S
-
GRPG
P
V
V
VDLP
K
D
I
LNPANKLP
YVW
PESVSMRSYNPT-
-
-TTGHKGQ
I
KR
A
LQT
L
VA
A
KK
P
V
V
YV
G
G
G
AIM
A
G
C
HQQ
L
K
E
TVEALNL
P
VVSS
L
M
GLG
AF
P
AT
H
R
QAL
GM
L
GM
H
G
TYEANMT
M
H
NAD
V
I
FA
VG
V
RF
DD
R
TTNNLAK
Y
C
P
-
NA
TV
L
HIDIDP
T
S
I
SKTVTAD
I
P
IVGD
ARQV
L
EQ
M
L
EL
L
SQESAHQ
PL
D
EI
RD
W
W
Q
QIEQW
R
ARQCLKYD--THS
E
----------------------------
K
-
IKPQAVIET
L
WR
----
LTKGDAYV
T
S
DVG
QH
QM
F
AA
LY
-
YPFDK
PR
RW
I
N
S
G
--------
GL
G
T
MG
F
GLP
A
A
L
G
V
KM
A
L
P
EET
VVC
VT
GDG
SIQ
M
NIQ
E
LS
T
AL
Q
YE
LPV
L
V
V
NL
NN
RY
LG
M
V
K
-
QWQD
M
IYSGRHSQSYMQSL
-----------
PD
F
VR
LA
E
A
Y
G
HV
G
IQ
I
SHPH
E
LES
K
L
SEALEQ
V
C
N
NR
L
VF
V
D
V
T
V
D
GS
--------
E
HVY
P
M
Q
IR
G
G
G
M
D
EMWLSKTERT
fig|573235.3.peg.82
Escherichia coli O26:H11 str. 11368
MV
V
RS
L
IDQ
GV
KQ
V
F
G
YP
G
GA
V
LD
I
Y
D
A
L
HTV
-
G
G
I
D
H
V
LV
RHEQ
A
A
VHM
A
D
G
L
A
RAT
G
E
V
GV
--
V
LVT
SGPG
A
TN
A
ITG
I
A
T
A
YM
D
SI
PL
V
V
L
SG
QVATSL
IG
--
Y
D
A
FQE
C
D
MV
--------
GISRPVV
K
HSF
LV
KQT
ED
I
P
QV
L
KK
A
FWL
A
A
S
-
GRPG
P
V
V
VDLP
K
D
I
LNPANKLP
YVW
PESVSMRSYNPT-
-
-TTGHKGQ
I
KR
A
LQT
L
VA
A
KK
P
V
V
YV
G
G
G
AIM
A
G
C
HQQ
L
K
E
TVEALNL
P
VVSS
L
M
GLG
AF
P
AT
H
R
QAL
GM
L
GM
H
G
TYEANMT
M
H
NAD
V
I
FA
VG
V
RF
DD
R
TTNNLAK
Y
C
P
-
NA
TV
L
HIDIDP
T
S
I
SKTVTAD
I
P
IVGD
ARQV
L
EQ
M
L
EL
L
SQESAHQ
PL
D
EI
RD
W
W
Q
QIEQW
R
ARQCLKYD--THS
E
----------------------------
K
-
IKPQAVIET
L
WR
----
LTKGDAYV
T
S
DVG
QH
QM
F
AA
LY
-
YPFDK
PR
RW
I
N
S
G
--------
GL
G
T
MG
F
GLP
A
A
L
G
V
KM
A
L
P
EET
VVC
VT
GDG
SIQ
M
NIQ
E
LS
T
AL
Q
YE
LPV
L
V
V
NL
NN
RY
LG
M
V
K
-
QWQD
M
IYSGRHSQSYMQSL
-----------
PD
F
VR
LA
E
A
Y
G
HV
G
IQ
I
SHPH
E
LES
K
L
SEALEQ
V
C
N
NR
L
VF
V
D
V
T
V
D
GS
--------
E
HVY
P
M
Q
IR
G
G
G
M
D
EMWLSKTERT
fig|550672.3.peg.4349
Escherichia coli B088
MV
V
RS
L
IDQ
GV
KQ
V
F
G
YP
G
GA
V
LD
I
Y
D
A
L
HTV
-
G
G
I
D
H
V
LV
RHEQ
A
A
VHM
A
D
G
L
A
RAT
G
E
V
GV
--
V
LVT
SGPG
A
TN
A
ITG
I
A
T
A
YM
D
SI
PL
V
V
L
SG
QVATSL
IG
--
Y
D
A
FQE
C
D
MV
--------
GISRPVV
K
HSF
LV
KQT
ED
I
P
QV
L
KK
A
FWL
A
A
S
-
GRPG
P
V
V
VDLP
K
D
I
LNPANKLP
YVW
PESVSMRSYNPT-
-
-TTGHKGQ
I
KR
A
LQT
L
VA
A
KK
P
V
V
YV
G
G
G
AIM
A
G
C
HQQ
L
K
E
TVEALNL
P
VVSS
L
M
GLG
AF
P
AT
H
R
QAL
GM
L
GM
H
G
TYEANMT
M
H
NAD
V
I
FA
VG
V
RF
DD
R
TTNNLAK
Y
C
P
-
NA
TV
L
HIDIDP
T
S
I
SKTVTAD
I
P
IVGD
ARQV
L
EQ
M
L
EL
L
SQESAHQ
PL
D
EI
RD
W
W
Q
QIEQW
R
ARQCLKYD--THS
E
----------------------------
K
-
IKPQAVIET
L
WR
----
LTKGDAYV
T
S
DVG
QH
QM
F
AA
LY
-
YPFDK
PR
RW
I
N
S
G
--------
GL
G
T
MG
F
GLP
A
A
L
G
V
KM
A
L
P
EET
VVC
VT
GDG
SIQ
M
NIQ
E
LS
T
AL
Q
YE
LPV
L
V
V
NL
NN
RY
LG
M
V
K
-
QWQD
M
IYSGRHSQSYMQSL
-----------
PD
F
VR
LA
E
A
Y
G
HV
G
IQ
I
SHPH
E
LES
K
L
SEALEQ
VRN
NR
L
VF
V
D
V
T
V
D
GS
--------
E
HVY
P
M
Q
IR
G
G
G
M
D
EMWLSKTERT
fig|340186.3.peg.4047
Escherichia coli E110019 (37-602/602)
MV
V
RS
L
IDQ
GV
KQ
V
F
G
YP
G
GA
V
LD
I
Y
D
A
L
HTV
-
G
G
I
D
H
V
LV
RHEQ
A
A
VHM
A
D
G
L
A
RAT
G
E
V
GV
--
V
LVT
SGPG
A
TN
A
ITG
I
A
T
A
YM
D
SI
PL
V
V
L
SG
QVATSL
IG
--
Y
D
A
FQE
C
D
MV
--------
GISRPVV
K
HSF
LV
KQT
ED
I
P
QV
L
KK
A
FWL
A
A
S
-
GRPG
P
V
V
VDLP
K
D
I
LNPANKLP
YVW
PESVSMRSYNPT-
-
-TTGHKGQ
I
KR
A
LQT
L
VA
A
KK
P
V
V
YV
G
G
G
AIM
A
G
C
HQQ
L
K
E
TVEALNL
P
VVSS
L
M
GLG
AF
P
AT
H
R
QAL
GM
L
GM
H
G
TYEANMT
M
H
NAD
V
I
FA
VG
V
RF
DD
R
TTNNLAK
Y
C
P
-
NA
TV
L
HIDIDP
T
S
I
SKTVTAD
I
P
IVGD
ARQV
L
EQ
M
L
EL
L
SQESAHQ
PL
D
EI
RD
W
W
Q
QIEQW
R
ARQCLKYD--THS
E
----------------------------
K
-
IKPQAVIET
L
WR
----
LTKGDAYV
T
S
DVG
QH
QM
F
AA
LY
-
YPFDK
PR
RW
I
N
S
G
--------
GL
G
T
MG
F
GLP
A
A
L
G
V
KM
A
L
P
EET
VVC
VT
GDG
SIQ
M
NIQ
E
LS
T
AL
Q
YE
LPV
L
V
V
NL
NN
RY
LG
M
V
K
-
QWQD
M
IYSGRHSQSYMQSL
-----------
PD
F
VR
LA
E
A
Y
G
HV
G
IQ
I
SHPH
E
LES
K
L
SEALEQ
VRN
NR
L
VF
V
D
V
T
V
D
GS
--------
E
HVY
P
M
Q
IR
G
G
G
M
D
EMWLSKTERT
fig|340186.5.peg.4254
Escherichia coli E110019 (9-574/574)
MV
V
RS
L
IDQ
GV
KQ
V
F
G
YP
G
GA
V
LD
I
Y
D
A
L
HTV
-
G
G
I
D
H
V
LV
RHEQ
A
A
VHM
A
D
G
L
A
RAT
G
E
V
GV
--
V
LVT
SGPG
A
TN
A
ITG
I
A
T
A
YM
D
SI
PL
V
V
L
SG
QVATSL
IG
--
Y
D
A
FQE
C
D
MV
--------
GISRPVV
K
HSF
LV
KQT
ED
I
P
QV
L
KK
A
FWL
A
A
S
-
GRPG
P
V
V
VDLP
K
D
I
LNPANKLP
YVW
PESVSMRSYNPT-
-
-TTGHKGQ
I
KR
A
LQT
L
VA
A
KK
P
V
V
YV
G
G
G
AIM
A
G
C
HQQ
L
K
E
TVEALNL
P
VVSS
L
M
GLG
AF
P
AT
H
R
QAL
GM
L
GM
H
G
TYEANMT
M
H
NAD
V
I
FA
VG
V
RF
DD
R
TTNNLAK
Y
C
P
-
NA
TV
L
HIDIDP
T
S
I
SKTVTAD
I
P
IVGD
ARQV
L
EQ
M
L
EL
L
SQESAHQ
PL
D
EI
RD
W
W
Q
QIEQW
R
ARQCLKYD--THS
E
----------------------------
K
-
IKPQAVIET
L
WR
----
LTKGDAYV
T
S
DVG
QH
QM
F
AA
LY
-
YPFDK
PR
RW
I
N
S
G
--------
GL
G
T
MG
F
GLP
A
A
L
G
V
KM
A
L
P
EET
VVC
VT
GDG
SIQ
M
NIQ
E
LS
T
AL
Q
YE
LPV
L
V
V
NL
NN
RY
LG
M
V
K
-
QWQD
M
IYSGRHSQSYMQSL
-----------
PD
F
VR
LA
E
A
Y
G
HV
G
IQ
I
SHPH
E
LES
K
L
SEALEQ
VRN
NR
L
VF
V
D
V
T
V
D
GS
--------
E
HVY
P
M
Q
IR
G
G
G
M
D
EMWLSKTERT
fig|585034.4.peg.79
Escherichia coli IAI1
MV
V
RS
L
IDQ
GV
KQ
V
F
G
YP
G
GA
V
LD
I
Y
D
A
L
HTV
-
G
G
I
D
H
V
LV
RHEQ
A
A
VHM
A
D
G
L
A
RAT
G
E
V
GV
--
V
LVT
SGPG
A
TN
A
ITG
I
A
T
A
YM
D
SI
PL
V
V
L
SG
QVATSL
IG
--
Y
D
A
FQE
C
D
MV
--------
GISRPVV
K
HSF
LV
KQT
ED
I
P
QV
L
KK
A
FWL
A
A
S
-
GRPG
P
V
V
VDLP
K
D
I
LNPANKLP
YVW
PESVSMRSYNPT-
-
-TTGHKGQ
I
KR
A
LQT
L
VA
A
KK
P
V
V
YV
G
G
G
AIM
A
G
C
HQQ
L
K
E
TVEALNL
P
VVSS
L
M
GLG
AF
P
AT
H
R
QAL
GM
L
GM
H
G
TYEANMT
M
H
NAD
V
I
FA
VG
V
RF
DD
R
TTNNLAK
Y
C
P
-
NA
TV
L
HIDIDP
T
S
I
SKTVTAD
I
P
IVGD
ARQV
L
EQ
M
L
EL
L
SQESAHQ
PL
D
EI
RD
W
W
Q
QIEQW
R
ARQCLKYD--THS
E
----------------------------
K
-
IKPQAVIET
L
WR
----
LTKGDAYV
T
S
DVG
QH
QM
F
AA
LY
-
YPFDK
PR
RW
I
N
S
G
--------
GL
G
T
MG
F
GLP
A
A
L
G
V
KM
A
L
P
EET
VVC
VT
GDG
SIQ
M
NIQ
E
LS
T
AL
Q
YE
LPV
L
V
V
NL
NN
RY
LG
M
V
K
-
QWQD
M
IYSGRHSQSYMQSL
-----------
PD
F
VR
LA
E
A
Y
G
HV
G
IQ
I
SHPH
E
LES
K
L
SEALEQ
VRN
NR
L
VF
V
D
V
T
V
D
GS
--------
E
HVY
P
M
Q
IR
G
G
G
M
D
EMWLSKTERT
fig|585034.5.peg.79
Escherichia coli IAI1
MV
V
RS
L
IDQ
GV
KQ
V
F
G
YP
G
GA
V
LD
I
Y
D
A
L
HTV
-
G
G
I
D
H
V
LV
RHEQ
A
A
VHM
A
D
G
L
A
RAT
G
E
V
GV
--
V
LVT
SGPG
A
TN
A
ITG
I
A
T
A
YM
D
SI
PL
V
V
L
SG
QVATSL
IG
--
Y
D
A
FQE
C
D
MV
--------
GISRPVV
K
HSF
LV
KQT
ED
I
P
QV
L
KK
A
FWL
A
A
S
-
GRPG
P
V
V
VDLP
K
D
I
LNPANKLP
YVW
PESVSMRSYNPT-
-
-TTGHKGQ
I
KR
A
LQT
L
VA
A
KK
P
V
V
YV
G
G
G
AIM
A
G
C
HQQ
L
K
E
TVEALNL
P
VVSS
L
M
GLG
AF
P
AT
H
R
QAL
GM
L
GM
H
G
TYEANMT
M
H
NAD
V
I
FA
VG
V
RF
DD
R
TTNNLAK
Y
C
P
-
NA
TV
L
HIDIDP
T
S
I
SKTVTAD
I
P
IVGD
ARQV
L
EQ
M
L
EL
L
SQESAHQ
PL
D
EI
RD
W
W
Q
QIEQW
R
ARQCLKYD--THS
E
----------------------------
K
-
IKPQAVIET
L
WR
----
LTKGDAYV
T
S
DVG
QH
QM
F
AA
LY
-
YPFDK
PR
RW
I
N
S
G
--------
GL
G
T
MG
F
GLP
A
A
L
G
V
KM
A
L
P
EET
VVC
VT
GDG
SIQ
M
NIQ
E
LS
T
AL
Q
YE
LPV
L
V
V
NL
NN
RY
LG
M
V
K
-
QWQD
M
IYSGRHSQSYMQSL
-----------
PD
F
VR
LA
E
A
Y
G
HV
G
IQ
I
SHPH
E
LES
K
L
SEALEQ
VRN
NR
L
VF
V
D
V
T
V
D
GS
--------
E
HVY
P
M
Q
IR
G
G
G
M
D
EMWLSKTERT
fig|409438.11.peg.196
Escherichia coli SE11
MV
V
RS
L
IDQ
GV
KQ
V
F
G
YP
G
GA
V
LD
I
Y
D
A
L
HTV
-
G
G
I
D
H
V
LV
RHEQ
A
A
VHM
A
D
G
L
A
RAT
G
E
V
GV
--
V
LVT
SGPG
A
TN
A
ITG
I
A
T
A
YM
D
SI
PL
V
V
L
SG
QVATSL
IG
--
Y
D
A
FQE
C
D
MV
--------
GISRPVV
K
HSF
LV
KQT
ED
I
P
QV
L
KK
A
FWL
A
A
S
-
GRPG
P
V
V
VDLP
K
D
I
LNPANKLP
YVW
PESVSMRSYNPT-
-
-TTGHKGQ
I
KR
A
LQT
L
VA
A
KK
P
V
V
YV
G
G
G
AIM
A
G
C
HQQ
L
K
E
TVEALNL
P
VVSS
L
M
GLG
AF
P
AT
H
R
QAL
GM
L
GM
H
G
TYEANMT
M
H
NAD
V
I
FA
VG
V
RF
DD
R
TTNNLAK
Y
C
P
-
NA
TV
L
HIDIDP
T
S
I
SKTVTAD
I
P
IVGD
ARQV
L
EQ
M
L
EL
L
SQESAHQ
PL
D
EI
RD
W
W
Q
QIEQW
R
ARQCLKYD--THS
E
----------------------------
K
-
IKPQAVIET
L
WR
----
LTKGDAYV
T
S
DVG
QH
QM
F
AA
LY
-
YPFDK
PR
RW
I
N
S
G
--------
GL
G
T
MG
F
GLP
A
A
L
G
V
KM
A
L
P
EET
VVC
VT
GDG
SIQ
M
NIQ
E
LS
T
AL
Q
YE
LPV
L
V
V
NL
NN
RY
LG
M
V
K
-
QWQD
M
IYSGRHSQSYMQSL
-----------
PD
F
VR
LA
E
A
Y
G
HV
G
IQ
I
SHPH
E
LES
K
L
SEALEQ
VRN
NR
L
VF
V
D
V
T
V
D
GS
--------
E
HVY
P
M
Q
IR
G
G
G
M
D
EMWLSKTERT
fig|216592.1.peg.4331
Escherichia coli 042 (37-602/602)
MV
V
RS
L
IDQ
GV
KQ
V
F
G
YP
G
GA
V
LD
I
Y
D
A
L
HTV
-
G
G
I
D
H
V
LV
RHEQ
A
A
VHM
A
D
G
L
A
RAT
G
E
V
GV
--
V
LVT
SGPG
A
TN
A
ITG
I
A
T
A
YM
D
SI
PL
V
V
L
SG
QVATSL
IG
--
Y
D
A
FQE
C
D
MV
--------
GISRPVV
K
HSF
LV
KQT
ED
I
P
QV
L
KK
A
FWL
A
A
S
-
GRPG
P
V
V
VDLP
K
D
I
LNPANKLP
YVW
PESVSMRSYNPT-
-
-TTGHKGQ
I
KR
A
LQT
L
VA
A
KK
P
V
V
YV
G
G
G
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
VVSS
L
M
GLG
AF
P
AT
H
R
QAL
GM
L
GM
H
G
TYEANMT
M
H
NAD
V
I
FA
VG
V
RF
DD
R
TTNNLAK
Y
C
P
-
NA
TV
L
HIDIDP
T
S
I
SKTVTAD
I
P
IVGD
ARQV
L
EQ
M
L
EL
L
SQESAHQ
PL
D
EI
RD
W
W
Q
QIEQW
R
ARQCLKYD--THS
E
----------------------------
K
-
IKPQAVIET
L
WR
----
LTKGDAYV
T
S
DVG
QH
QM
F
AA
LY
-
YPFDK
PR
RW
I
N
S
G
--------
GL
G
T
MG
F
GLP
A
A
L
G
V
KM
A
L
P
EET
VVC
VT
GDG
SIQ
M
NIQ
E
LS
T
AL
Q
YE
LPV
L
V
V
NL
NN
RY
LG
M
V
K
-
QWQD
M
IYSGRHSQSYMQSL
-----------
PD
F
VR
LA
E
A
Y
G
HV
G
IQ
I
SHPH
E
LES
K
L
SEALEQ
VRN
NR
L
VF
V
D
V
T
V
D
GS
--------
E
HVY
P
M
Q
IR
G
G
G
M
D
EMWLSKTERT
fig|216592.3.peg.88
Escherichia coli 042
MV
V
RS
L
IDQ
GV
KQ
V
F
G
YP
G
GA
V
LD
I
Y
D
A
L
HTV
-
G
G
I
D
H
V
LV
RHEQ
A
A
VHM
A
D
G
L
A
RAT
G
E
V
GV
--
V
LVT
SGPG
A
TN
A
ITG
I
A
T
A
YM
D
SI
PL
V
V
L
SG
QVATSL
IG
--
Y
D
A
FQE
C
D
MV
--------
GISRPVV
K
HSF
LV
KQT
ED
I
P
QV
L
KK
A
FWL
A
A
S
-
GRPG
P
V
V
VDLP
K
D
I
LNPANKLP
YVW
PESVSMRSYNPT-
-
-TTGHKGQ
I
KR
A
LQT
L
VA
A
KK
P
V
V
YV
G
G
G
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
VVSS
L
M
GLG
AF
P
AT
H
R
QAL
GM
L
GM
H
G
TYEANMT
M
H
NAD
V
I
FA
VG
V
RF
DD
R
TTNNLAK
Y
C
P
-
NA
TV
L
HIDIDP
T
S
I
SKTVTAD
I
P
IVGD
ARQV
L
EQ
M
L
EL
L
SQESAHQ
PL
D
EI
RD
W
W
Q
QIEQW
R
ARQCLKYD--THS
E
----------------------------
K
-
IKPQAVIET
L
WR
----
LTKGDAYV
T
S
DVG
QH
QM
F
AA
LY
-
YPFDK
PR
RW
I
N
S
G
--------
GL
G
T
MG
F
GLP
A
A
L
G
V
KM
A
L
P
EET
VVC
VT
GDG
SIQ
M
NIQ
E
LS
T
AL
Q
YE
LPV
L
V
V
NL
NN
RY
LG
M
V
K
-
QWQD
M
IYSGRHSQSYMQSL
-----------
PD
F
VR
LA
E
A
Y
G
HV
G
IQ
I
SHPH
E
LES
K
L
SEALEQ
VRN
NR
L
VF
V
D
V
T
V
D
GS
--------
E
HVY
P
M
Q
IR
G
G
G
M
D
EMWLSKTERT
fig|550676.3.peg.4746
Escherichia coli B185
MV
V
RS
L
IDQ
GV
KQ
V
F
G
YP
G
GA
V
LD
I
Y
D
A
L
HTV
-
G
G
I
D
H
V
LV
RHEQ
A
A
VHM
A
D
G
L
A
RAT
G
E
V
GV
--
V
LVT
SGPG
A
TN
A
ITG
I
A
T
A
YM
D
SI
PL
V
V
L
SG
QVATSL
IG
--
Y
D
A
FQE
C
D
MV
--------
GISRPVV
K
HSF
LV
KQT
ED
I
P
QV
L
KK
A
FWL
A
A
S
-
GRPG
P
V
V
VDLP
K
D
I
LNPANKLP
YVW
PESVSMRSYNPT-
-
-TTGHKGQ
I
KR
A
LQT
L
VA
A
KK
P
V
V
YV
G
G
G
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
VVSS
L
M
GLG
AF
P
AT
H
R
QAL
GM
L
GM
H
G
TYEANMT
M
H
NAD
V
I
FA
VG
V
RF
DD
R
TTNNLAK
Y
C
P
-
NA
TV
L
HIDIDP
T
S
I
SKTVTAD
I
P
IVGD
ARQV
L
EQ
M
L
EL
L
SQESAHQ
PL
D
EI
RD
W
W
Q
QIEQW
R
ARQCLKYD--THS
E
----------------------------
K
-
IKPQAVIET
L
WR
----
LTKGDAYV
T
S
DVG
QH
QM
F
AA
LY
-
YPFDK
PR
RW
I
N
S
G
--------
GL
G
T
MG
F
GLP
A
A
L
G
V
KM
A
L
P
EET
VVC
VT
GDG
SIQ
M
NIQ
E
LS
T
AL
Q
YE
LPV
L
V
V
NL
NN
RY
LG
M
V
K
-
QWQD
M
IYSGRHSQSYMQSL
-----------
PD
F
VR
LA
E
A
Y
G
HV
G
IQ
I
SHPH
E
LES
K
L
SEALEQ
VRN
NR
L
VF
V
D
V
T
V
D
GS
--------
E
HVY
P
M
Q
IR
G
G
G
M
D
EMWLSKTERT
fig|340184.3.peg.2847
Escherichia coli B7A (37-602/602)
MV
V
RS
L
IDQ
GV
KQ
V
F
G
YP
G
GA
V
LD
I
Y
D
A
L
HTV
-
G
G
I
D
H
V
LV
RHEQ
A
A
VHM
A
D
G
L
A
RAT
G
E
V
GV
--
V
LVT
SGPG
A
TN
A
ITG
I
A
T
A
YM
D
SI
PL
V
V
L
SG
QVATSL
IG
--
Y
D
A
FQE
C
D
MV
--------
GISRPVV
K
HSF
LV
KQT
ED
I
P
QV
L
KK
A
FWL
A
A
S
-
GRPG
P
V
V
VDLP
K
D
I
LNPANKLP
YVW
PESVSMRSYNPT-
-
-TTGHKGQ
I
KR
A
LQT
L
VA
A
KK
P
V
V
YV
G
G
G
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
VVSS
L
M
GLG
AF
P
AT
H
R
QAL
GM
L
GM
H
G
TYEANMT
M
H
NAD
V
I
FA
VG
V
RF
DD
R
TTNNLAK
Y
C
P
-
NA
TV
L
HIDIDP
T
S
I
SKTVTAD
I
P
IVGD
ARQV
L
EQ
M
L
EL
L
SQESAHQ
PL
D
EI
RD
W
W
Q
QIEQW
R
ARQCLKYD--THS
E
----------------------------
K
-
IKPQAVIET
L
WR
----
LTKGDAYV
T
S
DVG
QH
QM
F
AA
LY
-
YPFDK
PR
RW
I
N
S
G
--------
GL
G
T
MG
F
GLP
A
A
L
G
V
KM
A
L
P
EET
VVC
VT
GDG
SIQ
M
NIQ
E
LS
T
AL
Q
YE
LPV
L
V
V
NL
NN
RY
LG
M
V
K
-
QWQD
M
IYSGRHSQSYMQSL
-----------
PD
F
VR
LA
E
A
Y
G
HV
G
IQ
I
SHPH
E
LES
K
L
SEALEQ
VRN
NR
L
VF
V
D
V
T
V
D
GS
--------
E
HVY
P
M
Q
IR
G
G
G
M
D
EMWLSKTERT
fig|340184.6.peg.2978
Escherichia coli B7A
MV
V
RS
L
IDQ
GV
KQ
V
F
G
YP
G
GA
V
LD
I
Y
D
A
L
HTV
-
G
G
I
D
H
V
LV
RHEQ
A
A
VHM
A
D
G
L
A
RAT
G
E
V
GV
--
V
LVT
SGPG
A
TN
A
ITG
I
A
T
A
YM
D
SI
PL
V
V
L
SG
QVATSL
IG
--
Y
D
A
FQE
C
D
MV
--------
GISRPVV
K
HSF
LV
KQT
ED
I
P
QV
L
KK
A
FWL
A
A
S
-
GRPG
P
V
V
VDLP
K
D
I
LNPANKLP
YVW
PESVSMRSYNPT-
-
-TTGHKGQ
I
KR
A
LQT
L
VA
A
KK
P
V
V
YV
G
G
G
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
VVSS
L
M
GLG
AF
P
AT
H
R
QAL
GM
L
GM
H
G
TYEANMT
M
H
NAD
V
I
FA
VG
V
RF
DD
R
TTNNLAK
Y
C
P
-
NA
TV
L
HIDIDP
T
S
I
SKTVTAD
I
P
IVGD
ARQV
L
EQ
M
L
EL
L
SQESAHQ
PL
D
EI
RD
W
W
Q
QIEQW
R
ARQCLKYD--THS
E
----------------------------
K
-
IKPQAVIET
L
WR
----
LTKGDAYV
T
S
DVG
QH
QM
F
AA
LY
-
YPFDK
PR
RW
I
N
S
G
--------
GL
G
T
MG
F
GLP
A
A
L
G
V
KM
A
L
P
EET
VVC
VT
GDG
SIQ
M
NIQ
E
LS
T
AL
Q
YE
LPV
L
V
V
NL
NN
RY
LG
M
V
K
-
QWQD
M
IYSGRHSQSYMQSL
-----------
PD
F
VR
LA
E
A
Y
G
HV
G
IQ
I
SHPH
E
LES
K
L
SEALEQ
VRN
NR
L
VF
V
D
V
T
V
D
GS
--------
E
HVY
P
M
Q
IR
G
G
G
M
D
EMWLSKTERT
fig|331111.12.peg.410
Escherichia coli E24377A
MV
V
RS
L
IDQ
GV
KQ
V
F
G
YP
G
GA
V
LD
I
Y
D
A
L
HTV
-
G
G
I
D
H
V
LV
RHEQ
A
A
VHM
A
D
G
L
A
RAT
G
E
V
GV
--
V
LVT
SGPG
A
TN
A
ITG
I
A
T
A
YM
D
SI
PL
V
V
L
SG
QVATSL
IG
--
Y
D
A
FQE
C
D
MV
--------
GISRPVV
K
HSF
LV
KQT
ED
I
P
QV
L
KK
A
FWL
A
A
S
-
GRPG
P
V
V
VDLP
K
D
I
LNPANKLP
YVW
PESVSMRSYNPT-
-
-TTGHKGQ
I
KR
A
LQT
L
VA
A
KK
P
V
V
YV
G
G
G
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
VVSS
L
M
GLG
AF
P
AT
H
R
QAL
GM
L
GM
H
G
TYEANMT
M
H
NAD
V
I
FA
VG
V
RF
DD
R
TTNNLAK
Y
C
P
-
NA
TV
L
HIDIDP
T
S
I
SKTVTAD
I
P
IVGD
ARQV
L
EQ
M
L
EL
L
SQESAHQ
PL
D
EI
RD
W
W
Q
QIEQW
R
ARQCLKYD--THS
E
----------------------------
K
-
IKPQAVIET
L
WR
----
LTKGDAYV
T
S
DVG
QH
QM
F
AA
LY
-
YPFDK
PR
RW
I
N
S
G
--------
GL
G
T
MG
F
GLP
A
A
L
G
V
KM
A
L
P
EET
VVC
VT
GDG
SIQ
M
NIQ
E
LS
T
AL
Q
YE
LPV
L
V
V
NL
NN
RY
LG
M
V
K
-
QWQD
M
IYSGRHSQSYMQSL
-----------
PD
F
VR
LA
E
A
Y
G
HV
G
IQ
I
SHPH
E
LES
K
L
SEALEQ
VRN
NR
L
VF
V
D
V
T
V
D
GS
--------
E
HVY
P
M
Q
IR
G
G
G
M
D
EMWLSKTERT
fig|331111.3.peg.2649
Escherichia coli E24377A (37-602/602)
MV
V
RS
L
IDQ
GV
KQ
V
F
G
YP
G
GA
V
LD
I
Y
D
A
L
HTV
-
G
G
I
D
H
V
LV
RHEQ
A
A
VHM
A
D
G
L
A
RAT
G
E
V
GV
--
V
LVT
SGPG
A
TN
A
ITG
I
A
T
A
YM
D
SI
PL
V
V
L
SG
QVATSL
IG
--
Y
D
A
FQE
C
D
MV
--------
GISRPVV
K
HSF
LV
KQT
ED
I
P
QV
L
KK
A
FWL
A
A
S
-
GRPG
P
V
V
VDLP
K
D
I
LNPANKLP
YVW
PESVSMRSYNPT-
-
-TTGHKGQ
I
KR
A
LQT
L
VA
A
KK
P
V
V
YV
G
G
G
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
VVSS
L
M
GLG
AF
P
AT
H
R
QAL
GM
L
GM
H
G
TYEANMT
M
H
NAD
V
I
FA
VG
V
RF
DD
R
TTNNLAK
Y
C
P
-
NA
TV
L
HIDIDP
T
S
I
SKTVTAD
I
P
IVGD
ARQV
L
EQ
M
L
EL
L
SQESAHQ
PL
D
EI
RD
W
W
Q
QIEQW
R
ARQCLKYD--THS
E
----------------------------
K
-
IKPQAVIET
L
WR
----
LTKGDAYV
T
S
DVG
QH
QM
F
AA
LY
-
YPFDK
PR
RW
I
N
S
G
--------
GL
G
T
MG
F
GLP
A
A
L
G
V
KM
A
L
P
EET
VVC
VT
GDG
SIQ
M
NIQ
E
LS
T
AL
Q
YE
LPV
L
V
V
NL
NN
RY
LG
M
V
K
-
QWQD
M
IYSGRHSQSYMQSL
-----------
PD
F
VR
LA
E
A
Y
G
HV
G
IQ
I
SHPH
E
LES
K
L
SEALEQ
VRN
NR
L
VF
V
D
V
T
V
D
GS
--------
E
HVY
P
M
Q
IR
G
G
G
M
D
EMWLSKTERT
fig|656408.3.peg.5031
Escherichia coli H591
MV
V
RS
L
IDQ
GV
KQ
V
F
G
YP
G
GA
V
LD
I
Y
D
A
L
HTV
-
G
G
I
D
H
V
LV
RHEQ
A
A
VHM
A
D
G
L
A
RAT
G
E
V
GV
--
V
LVT
SGPG
A
TN
A
ITG
I
A
T
A
YM
D
SI
PL
V
V
L
SG
QVATSL
IG
--
Y
D
A
FQE
C
D
MV
--------
GISRPVV
K
HSF
LV
KQT
ED
I
P
QV
L
KK
A
FWL
A
A
S
-
GRPG
P
V
V
VDLP
K
D
I
LNPANKLP
YVW
PESVSMRSYNPT-
-
-TTGHKGQ
I
KR
A
LQT
L
VA
A
KK
P
V
V
YV
G
G
G
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
VVSS
L
M
GLG
AF
P
AT
H
R
QAL
GM
L
GM
H
G
TYEANMT
M
H
NAD
V
I
FA
VG
V
RF
DD
R
TTNNLAK
Y
C
P
-
NA
TV
L
HIDIDP
T
S
I
SKTVTAD
I
P
IVGD
ARQV
L
EQ
M
L
EL
L
SQESAHQ
PL
D
EI
RD
W
W
Q
QIEQW
R
ARQCLKYD--THS
E
----------------------------
K
-
IKPQAVIET
L
WR
----
LTKGDAYV
T
S
DVG
QH
QM
F
AA
LY
-
YPFDK
PR
RW
I
N
S
G
--------
GL
G
T
MG
F
GLP
A
A
L
G
V
KM
A
L
P
EET
VVC
VT
GDG
SIQ
M
NIQ
E
LS
T
AL
Q
YE
LPV
L
V
V
NL
NN
RY
LG
M
V
K
-
QWQD
M
IYSGRHSQSYMQSL
-----------
PD
F
VR
LA
E
A
Y
G
HV
G
IQ
I
SHPH
E
LES
K
L
SEALEQ
VRN
NR
L
VF
V
D
V
T
V
D
GS
--------
E
HVY
P
M
Q
IR
G
G
G
M
D
EMWLSKTERT
fig|595495.4.peg.1647
Escherichia coli KO11
MV
V
RS
L
IDQ
GV
KQ
V
F
G
YP
G
GA
V
LD
I
Y
D
A
L
HTV
-
G
G
I
D
H
V
LV
RHEQ
A
A
VHM
A
D
G
L
A
RAT
G
E
V
GV
--
V
LVT
SGPG
A
TN
A
ITG
I
A
T
A
YM
D
SI
PL
V
V
L
SG
QVATSL
IG
--
Y
D
A
FQE
C
D
MV
--------
GISRPVV
K
HSF
LV
KQT
ED
I
P
QV
L
KK
A
FWL
A
A
S
-
GRPG
P
V
V
VDLP
K
D
I
LNPANKLP
YVW
PESVSMRSYNPT-
-
-TTGHKGQ
I
KR
A
LQT
L
VA
A
KK
P
V
V
YV
G
G
G
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
VVSS
L
M
GLG
AF
P
AT
H
R
QAL
GM
L
GM
H
G
TYEANMT
M
H
NAD
V
I
FA
VG
V
RF
DD
R
TTNNLAK
Y
C
P
-
NA
TV
L
HIDIDP
T
S
I
SKTVTAD
I
P
IVGD
ARQV
L
EQ
M
L
EL
L
SQESAHQ
PL
D
EI
RD
W
W
Q
QIEQW
R
ARQCLKYD--THS
E
----------------------------
K
-
IKPQAVIET
L
WR
----
LTKGDAYV
T
S
DVG
QH
QM
F
AA
LY
-
YPFDK
PR
RW
I
N
S
G
--------
GL
G
T
MG
F
GLP
A
A
L
G
V
KM
A
L
P
EET
VVC
VT
GDG
SIQ
M
NIQ
E
LS
T
AL
Q
YE
LPV
L
V
V
NL
NN
RY
LG
M
V
K
-
QWQD
M
IYSGRHSQSYMQSL
-----------
PD
F
VR
LA
E
A
Y
G
HV
G
IQ
I
SHPH
E
LES
K
L
SEALEQ
VRN
NR
L
VF
V
D
V
T
V
D
GS
--------
E
HVY
P
M
Q
IR
G
G
G
M
D
EMWLSKTERT
fig|679206.4.peg.1693
Escherichia coli MS 119-7
MV
V
RS
L
IDQ
GV
KQ
V
F
G
YP
G
GA
V
LD
I
Y
D
A
L
HTV
-
G
G
I
D
H
V
LV
RHEQ
A
A
VHM
A
D
G
L
A
RAT
G
E
V
GV
--
V
LVT
SGPG
A
TN
A
ITG
I
A
T
A
YM
D
SI
PL
V
V
L
SG
QVATSL
IG
--
Y
D
A
FQE
C
D
MV
--------
GISRPVV
K
HSF
LV
KQT
ED
I
P
QV
L
KK
A
FWL
A
A
S
-
GRPG
P
V
V
VDLP
K
D
I
LNPANKLP
YVW
PESVSMRSYNPT-
-
-TTGHKGQ
I
KR
A
LQT
L
VA
A
KK
P
V
V
YV
G
G
G
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
VVSS
L
M
GLG
AF
P
AT
H
R
QAL
GM
L
GM
H
G
TYEANMT
M
H
NAD
V
I
FA
VG
V
RF
DD
R
TTNNLAK
Y
C
P
-
NA
TV
L
HIDIDP
T
S
I
SKTVTAD
I
P
IVGD
ARQV
L
EQ
M
L
EL
L
SQESAHQ
PL
D
EI
RD
W
W
Q
QIEQW
R
ARQCLKYD--THS
E
----------------------------
K
-
IKPQAVIET
L
WR
----
LTKGDAYV
T
S
DVG
QH
QM
F
AA
LY
-
YPFDK
PR
RW
I
N
S
G
--------
GL
G
T
MG
F
GLP
A
A
L
G
V
KM
A
L
P
EET
VVC
VT
GDG
SIQ
M
NIQ
E
LS
T
AL
Q
YE
LPV
L
V
V
NL
NN
RY
LG
M
V
K
-
QWQD
M
IYSGRHSQSYMQSL
-----------
PD
F
VR
LA
E
A
Y
G
HV
G
IQ
I
SHPH
E
LES
K
L
SEALEQ
VRN
NR
L
VF
V
D
V
T
V
D
GS
--------
E
HVY
P
M
Q
IR
G
G
G
M
D
EMWLSKTERT
fig|679204.3.peg.3195
Escherichia coli MS 145-7 (9-574/574)
MV
V
RS
L
IDQ
GV
KQ
V
F
G
YP
G
GA
V
LD
I
Y
D
A
L
HTV
-
G
G
I
D
H
V
LV
RHEQ
A
A
VHM
A
D
G
L
A
RAT
G
E
V
GV
--
V
LVT
SGPG
A
TN
A
ITG
I
A
T
A
YM
D
SI
PL
V
V
L
SG
QVATSL
IG
--
Y
D
A
FQE
C
D
MV
--------
GISRPVV
K
HSF
LV
KQT
ED
I
P
QV
L
KK
A
FWL
A
A
S
-
GRPG
P
V
V
VDLP
K
D
I
LNPANKLP
YVW
PESVSMRSYNPT-
-
-TTGHKGQ
I
KR
A
LQT
L
VA
A
KK
P
V
V
YV
G
G
G
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
VVSS
L
M
GLG
AF
P
AT
H
R
QAL
GM
L
GM
H
G
TYEANMT
M
H
NAD
V
I
FA
VG
V
RF
DD
R
TTNNLAK
Y
C
P
-
NA
TV
L
HIDIDP
T
S
I
SKTVTAD
I
P
IVGD
ARQV
L
EQ
M
L
EL
L
SQESAHQ
PL
D
EI
RD
W
W
Q
QIEQW
R
ARQCLKYD--THS
E
----------------------------
K
-
IKPQAVIET
L
WR
----
LTKGDAYV
T
S
DVG
QH
QM
F
AA
LY
-
YPFDK
PR
RW
I
N
S
G
--------
GL
G
T
MG
F
GLP
A
A
L
G
V
KM
A
L
P
EET
VVC
VT
GDG
SIQ
M
NIQ
E
LS
T
AL
Q
YE
LPV
L
V
V
NL
NN
RY
LG
M
V
K
-
QWQD
M
IYSGRHSQSYMQSL
-----------
PD
F
VR
LA
E
A
Y
G
HV
G
IQ
I
SHPH
E
LES
K
L
SEALEQ
VRN
NR
L
VF
V
D
V
T
V
D
GS
--------
E
HVY
P
M
Q
IR
G
G
G
M
D
EMWLSKTERT
fig|749545.3.peg.1304
Escherichia coli MS 182-1 (9-574/574)
MV
V
RS
L
IDQ
GV
KQ
V
F
G
YP
G
GA
V
LD
I
Y
D
A
L
HTV
-
G
G
I
D
H
V
LV
RHEQ
A
A
VHM
A
D
G
L
A
RAT
G
E
V
GV
--
V
LVT
SGPG
A
TN
A
ITG
I
A
T
A
YM
D
SI
PL
V
V
L
SG
QVATSL
IG
--
Y
D
A
FQE
C
D
MV
--------
GISRPVV
K
HSF
LV
KQT
ED
I
P
QV
L
KK
A
FWL
A
A
S
-
GRPG
P
V
V
VDLP
K
D
I
LNPANKLP
YVW
PESVSMRSYNPT-
-
-TTGHKGQ
I
KR
A
LQT
L
VA
A
KK
P
V
V
YV
G
G
G
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
VVSS
L
M
GLG
AF
P
AT
H
R
QAL
GM
L
GM
H
G
TYEANMT
M
H
NAD
V
I
FA
VG
V
RF
DD
R
TTNNLAK
Y
C
P
-
NA
TV
L
HIDIDP
T
S
I
SKTVTAD
I
P
IVGD
ARQV
L
EQ
M
L
EL
L
SQESAHQ
PL
D
EI
RD
W
W
Q
QIEQW
R
ARQCLKYD--THS
E
----------------------------
K
-
IKPQAVIET
L
WR
----
LTKGDAYV
T
S
DVG
QH
QM
F
AA
LY
-
YPFDK
PR
RW
I
N
S
G
--------
GL
G
T
MG
F
GLP
A
A
L
G
V
KM
A
L
P
EET
VVC
VT
GDG
SIQ
M
NIQ
E
LS
T
AL
Q
YE
LPV
L
V
V
NL
NN
RY
LG
M
V
K
-
QWQD
M
IYSGRHSQSYMQSL
-----------
PD
F
VR
LA
E
A
Y
G
HV
G
IQ
I
SHPH
E
LES
K
L
SEALEQ
VRN
NR
L
VF
V
D
V
T
V
D
GS
--------
E
HVY
P
M
Q
IR
G
G
G
M
D
EMWLSKTERT
fig|749532.3.peg.4187
Escherichia coli MS 78-1
MV
V
RS
L
IDQ
GV
KQ
V
F
G
YP
G
GA
V
LD
I
Y
D
A
L
HTV
-
G
G
I
D
H
V
LV
RHEQ
A
A
VHM
A
D
G
L
A
RAT
G
E
V
GV
--
V
LVT
SGPG
A
TN
A
ITG
I
A
T
A
YM
D
SI
PL
V
V
L
SG
QVATSL
IG
--
Y
D
A
FQE
C
D
MV
--------
GISRPVV
K
HSF
LV
KQT
ED
I
P
QV
L
KK
A
FWL
A
A
S
-
GRPG
P
V
V
VDLP
K
D
I
LNPANKLP
YVW
PESVSMRSYNPT-
-
-TTGHKGQ
I
KR
A
LQT
L
VA
A
KK
P
V
V
YV
G
G
G
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
VVSS
L
M
GLG
AF
P
AT
H
R
QAL
GM
L
GM
H
G
TYEANMT
M
H
NAD
V
I
FA
VG
V
RF
DD
R
TTNNLAK
Y
C
P
-
NA
TV
L
HIDIDP
T
S
I
SKTVTAD
I
P
IVGD
ARQV
L
EQ
M
L
EL
L
SQESAHQ
PL
D
EI
RD
W
W
Q
QIEQW
R
ARQCLKYD--THS
E
----------------------------
K
-
IKPQAVIET
L
WR
----
LTKGDAYV
T
S
DVG
QH
QM
F
AA
LY
-
YPFDK
PR
RW
I
N
S
G
--------
GL
G
T
MG
F
GLP
A
A
L
G
V
KM
A
L
P
EET
VVC
VT
GDG
SIQ
M
NIQ
E
LS
T
AL
Q
YE
LPV
L
V
V
NL
NN
RY
LG
M
V
K
-
QWQD
M
IYSGRHSQSYMQSL
-----------
PD
F
VR
LA
E
A
Y
G
HV
G
IQ
I
SHPH
E
LES
K
L
SEALEQ
VRN
NR
L
VF
V
D
V
T
V
D
GS
--------
E
HVY
P
M
Q
IR
G
G
G
M
D
EMWLSKTERT
fig|656443.3.peg.209
Escherichia coli TA271
MV
V
RS
L
IDQ
GV
KQ
V
F
G
YP
G
GA
V
LD
I
Y
D
A
L
HTV
-
G
G
I
D
H
V
LV
RHEQ
A
A
VHM
A
D
G
L
A
RAT
G
E
V
GV
--
V
LVT
SGPG
A
TN
A
ITG
I
A
T
A
YM
D
SI
PL
V
V
L
SG
QVATSL
IG
--
Y
D
A
FQE
C
D
MV
--------
GISRPVV
K
HSF
LV
KQT
ED
I
P
QV
L
KK
A
FWL
A
A
S
-
GRPG
P
V
V
VDLP
K
D
I
LNPANKLP
YVW
PESVSMRSYNPT-
-
-TTGHKGQ
I
KR
A
LQT
L
VA
A
KK
P
V
V
YV
G
G
G
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
VVSS
L
M
GLG
AF
P
AT
H
R
QAL
GM
L
GM
H
G
TYEANMT
M
H
NAD
V
I
FA
VG
V
RF
DD
R
TTNNLAK
Y
C
P
-
NA
TV
L
HIDIDP
T
S
I
SKTVTAD
I
P
IVGD
ARQV
L
EQ
M
L
EL
L
SQESAHQ
PL
D
EI
RD
W
W
Q
QIEQW
R
ARQCLKYD--THS
E
----------------------------
K
-
IKPQAVIET
L
WR
----
LTKGDAYV
T
S
DVG
QH
QM
F
AA
LY
-
YPFDK
PR
RW
I
N
S
G
--------
GL
G
T
MG
F
GLP
A
A
L
G
V
KM
A
L
P
EET
VVC
VT
GDG
SIQ
M
NIQ
E
LS
T
AL
Q
YE
LPV
L
V
V
NL
NN
RY
LG
M
V
K
-
QWQD
M
IYSGRHSQSYMQSL
-----------
PD
F
VR
LA
E
A
Y
G
HV
G
IQ
I
SHPH
E
LES
K
L
SEALEQ
VRN
NR
L
VF
V
D
V
T
V
D
GS
--------
E
HVY
P
M
Q
IR
G
G
G
M
D
EMWLSKTERT
fig|566546.3.peg.1653
Escherichia coli W
MV
V
RS
L
IDQ
GV
KQ
V
F
G
YP
G
GA
V
LD
I
Y
D
A
L
HTV
-
G
G
I
D
H
V
LV
RHEQ
A
A
VHM
A
D
G
L
A
RAT
G
E
V
GV
--
V
LVT
SGPG
A
TN
A
ITG
I
A
T
A
YM
D
SI
PL
V
V
L
SG
QVATSL
IG
--
Y
D
A
FQE
C
D
MV
--------
GISRPVV
K
HSF
LV
KQT
ED
I
P
QV
L
KK
A
FWL
A
A
S
-
GRPG
P
V
V
VDLP
K
D
I
LNPANKLP
YVW
PESVSMRSYNPT-
-
-TTGHKGQ
I
KR
A
LQT
L
VA
A
KK
P
V
V
YV
G
G
G
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
VVSS
L
M
GLG
AF
P
AT
H
R
QAL
GM
L
GM
H
G
TYEANMT
M
H
NAD
V
I
FA
VG
V
RF
DD
R
TTNNLAK
Y
C
P
-
NA
TV
L
HIDIDP
T
S
I
SKTVTAD
I
P
IVGD
ARQV
L
EQ
M
L
EL
L
SQESAHQ
PL
D
EI
RD
W
W
Q
QIEQW
R
ARQCLKYD--THS
E
----------------------------
K
-
IKPQAVIET
L
WR
----
LTKGDAYV
T
S
DVG
QH
QM
F
AA
LY
-
YPFDK
PR
RW
I
N
S
G
--------
GL
G
T
MG
F
GLP
A
A
L
G
V
KM
A
L
P
EET
VVC
VT
GDG
SIQ
M
NIQ
E
LS
T
AL
Q
YE
LPV
L
V
V
NL
NN
RY
LG
M
V
K
-
QWQD
M
IYSGRHSQSYMQSL
-----------
PD
F
VR
LA
E
A
Y
G
HV
G
IQ
I
SHPH
E
LES
K
L
SEALEQ
VRN
NR
L
VF
V
D
V
T
V
D
GS
--------
E
HVY
P
M
Q
IR
G
G
G
M
D
EMWLSKTERT
fig|566546.4.peg.76
Escherichia coli W
MV
V
RS
L
IDQ
GV
KQ
V
F
G
YP
G
GA
V
LD
I
Y
D
A
L
HTV
-
G
G
I
D
H
V
LV
RHEQ
A
A
VHM
A
D
G
L
A
RAT
G
E
V
GV
--
V
LVT
SGPG
A
TN
A
ITG
I
A
T
A
YM
D
SI
PL
V
V
L
SG
QVATSL
IG
--
Y
D
A
FQE
C
D
MV
--------
GISRPVV
K
HSF
LV
KQT
ED
I
P
QV
L
KK
A
FWL
A
A
S
-
GRPG
P
V
V
VDLP
K
D
I
LNPANKLP
YVW
PESVSMRSYNPT-
-
-TTGHKGQ
I
KR
A
LQT
L
VA
A
KK
P
V
V
YV
G
G
G
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
VVSS
L
M
GLG
AF
P
AT
H
R
QAL
GM
L
GM
H
G
TYEANMT
M
H
NAD
V
I
FA
VG
V
RF
DD
R
TTNNLAK
Y
C
P
-
NA
TV
L
HIDIDP
T
S
I
SKTVTAD
I
P
IVGD
ARQV
L
EQ
M
L
EL
L
SQESAHQ
PL
D
EI
RD
W
W
Q
QIEQW
R
ARQCLKYD--THS
E
----------------------------
K
-
IKPQAVIET
L
WR
----
LTKGDAYV
T
S
DVG
QH
QM
F
AA
LY
-
YPFDK
PR
RW
I
N
S
G
--------
GL
G
T
MG
F
GLP
A
A
L
G
V
KM
A
L
P
EET
VVC
VT
GDG
SIQ
M
NIQ
E
LS
T
AL
Q
YE
LPV
L
V
V
NL
NN
RY
LG
M
V
K
-
QWQD
M
IYSGRHSQSYMQSL
-----------
PD
F
VR
LA
E
A
Y
G
HV
G
IQ
I
SHPH
E
LES
K
L
SEALEQ
VRN
NR
L
VF
V
D
V
T
V
D
GS
--------
E
HVY
P
M
Q
IR
G
G
G
M
D
EMWLSKTERT
fig|670888.3.peg.657
Escherichia coli 1827-70
MV
V
RS
L
IDQ
GV
KQ
V
F
G
YP
G
GA
V
LD
I
Y
D
A
L
HTV
-
G
G
I
D
H
V
LV
RHEQ
A
A
VHM
A
D
G
L
A
RAT
G
E
V
GV
--
V
LVT
SGPG
A
TN
A
ITG
I
A
T
A
YM
D
SI
PL
V
V
L
SG
QVATSL
IG
--
Y
D
A
FQE
C
D
MV
--------
GISRPVV
K
HSF
LV
KQT
ED
I
P
QV
L
KK
A
FWL
A
A
S
-
GRPG
P
V
V
VDLP
K
D
I
LNPANKLP
YVW
PESVSMRSYNPT-
-
-TTGHKGQ
I
KR
A
LQT
L
VA
A
KK
P
V
V
YV
G
G
G
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
VVCS
L
M
GLG
AF
P
AT
H
R
QAL
GM
L
GM
H
G
TYEANMT
M
H
NAD
V
I
FA
VG
V
RF
DD
R
TTNNLAK
Y
C
P
-
NA
TV
L
HIDIDP
T
S
I
SKTVTAD
I
P
IVGD
ARQV
L
EQ
M
L
EL
L
SQESAHQ
PL
D
EI
RD
W
W
Q
QIEQW
R
ARQCLKYD--THS
E
----------------------------
K
-
IKPQAVIET
L
WR
----
LTKGDAYV
T
S
DVG
QH
QM
F
AA
LY
-
YPFDK
PR
RW
I
N
S
G
--------
GL
G
T
MG
F
GLP
A
A
L
G
V
KM
A
L
P
EET
VVC
VT
GDG
SIQ
M
NIQ
E
LS
T
AL
Q
YE
LPV
L
V
V
NL
NN
RY
LG
M
V
K
-
QWQD
M
IYSGRHSQSYMQSL
-----------
PD
F
VR
LA
E
A
Y
G
HV
G
IQ
I
SHPH
E
LES
K
L
SEALEQ
VRN
NR
L
VF
V
D
V
T
V
D
GS
--------
E
HVY
P
M
Q
IR
G
G
G
M
D
EMWLSKTERT
fig|344610.3.peg.4312
Escherichia coli 53638 (37-602/602)
MV
V
RS
L
IDQ
GV
KQ
V
F
G
YP
G
GA
V
LD
I
Y
D
A
L
HTV
-
G
G
I
D
H
V
LV
RHEQ
A
A
VHM
A
D
G
L
A
RAT
G
E
V
GV
--
V
LVT
SGPG
A
TN
A
ITG
I
A
T
A
YM
D
SI
PL
V
V
L
SG
QVATSL
IG
--
Y
D
A
FQE
C
D
MV
--------
GISRPVV
K
HSF
LV
KQT
ED
I
P
QV
L
KK
A
FWL
A
A
S
-
GRPG
P
V
V
VDLP
K
D
I
LNPANKLP
YVW
PESVSMRSYNPT-
-
-TTGHKGQ
I
KR
A
LQT
L
VA
A
KK
P
V
V
YV
G
G
G
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
VVCS
L
M
GLG
AF
P
AT
H
R
QAL
GM
L
GM
H
G
TYEANMT
M
H
NAD
V
I
FA
VG
V
RF
DD
R
TTNNLAK
Y
C
P
-
NA
TV
L
HIDIDP
T
S
I
SKTVTAD
I
P
IVGD
ARQV
L
EQ
M
L
EL
L
SQESAHQ
PL
D
EI
RD
W
W
Q
QIEQW
R
ARQCLKYD--THS
E
----------------------------
K
-
IKPQAVIET
L
WR
----
LTKGDAYV
T
S
DVG
QH
QM
F
AA
LY
-
YPFDK
PR
RW
I
N
S
G
--------
GL
G
T
MG
F
GLP
A
A
L
G
V
KM
A
L
P
EET
VVC
VT
GDG
SIQ
M
NIQ
E
LS
T
AL
Q
YE
LPV
L
V
V
NL
NN
RY
LG
M
V
K
-
QWQD
M
IYSGRHSQSYMQSL
-----------
PD
F
VR
LA
E
A
Y
G
HV
G
IQ
I
SHPH
E
LES
K
L
SEALEQ
VRN
NR
L
VF
V
D
V
T
V
D
GS
--------
E
HVY
P
M
Q
IR
G
G
G
M
D
EMWLSKTERT
fig|344610.7.peg.1660
Escherichia coli 53638
MV
V
RS
L
IDQ
GV
KQ
V
F
G
YP
G
GA
V
LD
I
Y
D
A
L
HTV
-
G
G
I
D
H
V
LV
RHEQ
A
A
VHM
A
D
G
L
A
RAT
G
E
V
GV
--
V
LVT
SGPG
A
TN
A
ITG
I
A
T
A
YM
D
SI
PL
V
V
L
SG
QVATSL
IG
--
Y
D
A
FQE
C
D
MV
--------
GISRPVV
K
HSF
LV
KQT
ED
I
P
QV
L
KK
A
FWL
A
A
S
-
GRPG
P
V
V
VDLP
K
D
I
LNPANKLP
YVW
PESVSMRSYNPT-
-
-TTGHKGQ
I
KR
A
LQT
L
VA
A
KK
P
V
V
YV
G
G
G
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
VVCS
L
M
GLG
AF
P
AT
H
R
QAL
GM
L
GM
H
G
TYEANMT
M
H
NAD
V
I
FA
VG
V
RF
DD
R
TTNNLAK
Y
C
P
-
NA
TV
L
HIDIDP
T
S
I
SKTVTAD
I
P
IVGD
ARQV
L
EQ
M
L
EL
L
SQESAHQ
PL
D
EI
RD
W
W
Q
QIEQW
R
ARQCLKYD--THS
E
----------------------------
K
-
IKPQAVIET
L
WR
----
LTKGDAYV
T
S
DVG
QH
QM
F
AA
LY
-
YPFDK
PR
RW
I
N
S
G
--------
GL
G
T
MG
F
GLP
A
A
L
G
V
KM
A
L
P
EET
VVC
VT
GDG
SIQ
M
NIQ
E
LS
T
AL
Q
YE
LPV
L
V
V
NL
NN
RY
LG
M
V
K
-
QWQD
M
IYSGRHSQSYMQSL
-----------
PD
F
VR
LA
E
A
Y
G
HV
G
IQ
I
SHPH
E
LES
K
L
SEALEQ
VRN
NR
L
VF
V
D
V
T
V
D
GS
--------
E
HVY
P
M
Q
IR
G
G
G
M
D
EMWLSKTERT
fig|481805.3.peg.3844
Escherichia coli ATCC 8739 (37-602/602)
MV
V
RS
L
IDQ
GV
KQ
V
F
G
YP
G
GA
V
LD
I
Y
D
A
L
HTV
-
G
G
I
D
H
V
LV
RHEQ
A
A
VHM
A
D
G
L
A
RAT
G
E
V
GV
--
V
LVT
SGPG
A
TN
A
ITG
I
A
T
A
YM
D
SI
PL
V
V
L
SG
QVATSL
IG
--
Y
D
A
FQE
C
D
MV
--------
GISRPVV
K
HSF
LV
KQT
ED
I
P
QV
L
KK
A
FWL
A
A
S
-
GRPG
P
V
V
VDLP
K
D
I
LNPANKLP
YVW
PESVSMRSYNPT-
-
-TTGHKGQ
I
KR
A
LQT
L
VA
A
KK
P
V
V
YV
G
G
G
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
VVCS
L
M
GLG
AF
P
AT
H
R
QAL
GM
L
GM
H
G
TYEANMT
M
H
NAD
V
I
FA
VG
V
RF
DD
R
TTNNLAK
Y
C
P
-
NA
TV
L
HIDIDP
T
S
I
SKTVTAD
I
P
IVGD
ARQV
L
EQ
M
L
EL
L
SQESAHQ
PL
D
EI
RD
W
W
Q
QIEQW
R
ARQCLKYD--THS
E
----------------------------
K
-
IKPQAVIET
L
WR
----
LTKGDAYV
T
S
DVG
QH
QM
F
AA
LY
-
YPFDK
PR
RW
I
N
S
G
--------
GL
G
T
MG
F
GLP
A
A
L
G
V
KM
A
L
P
EET
VVC
VT
GDG
SIQ
M
NIQ
E
LS
T
AL
Q
YE
LPV
L
V
V
NL
NN
RY
LG
M
V
K
-
QWQD
M
IYSGRHSQSYMQSL
-----------
PD
F
VR
LA
E
A
Y
G
HV
G
IQ
I
SHPH
E
LES
K
L
SEALEQ
VRN
NR
L
VF
V
D
V
T
V
D
GS
--------
E
HVY
P
M
Q
IR
G
G
G
M
D
EMWLSKTERT
fig|481805.6.peg.3823
Escherichia coli ATCC 8739
MV
V
RS
L
IDQ
GV
KQ
V
F
G
YP
G
GA
V
LD
I
Y
D
A
L
HTV
-
G
G
I
D
H
V
LV
RHEQ
A
A
VHM
A
D
G
L
A
RAT
G
E
V
GV
--
V
LVT
SGPG
A
TN
A
ITG
I
A
T
A
YM
D
SI
PL
V
V
L
SG
QVATSL
IG
--
Y
D
A
FQE
C
D
MV
--------
GISRPVV
K
HSF
LV
KQT
ED
I
P
QV
L
KK
A
FWL
A
A
S
-
GRPG
P
V
V
VDLP
K
D
I
LNPANKLP
YVW
PESVSMRSYNPT-
-
-TTGHKGQ
I
KR
A
LQT
L
VA
A
KK
P
V
V
YV
G
G
G
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
VVCS
L
M
GLG
AF
P
AT
H
R
QAL
GM
L
GM
H
G
TYEANMT
M
H
NAD
V
I
FA
VG
V
RF
DD
R
TTNNLAK
Y
C
P
-
NA
TV
L
HIDIDP
T
S
I
SKTVTAD
I
P
IVGD
ARQV
L
EQ
M
L
EL
L
SQESAHQ
PL
D
EI
RD
W
W
Q
QIEQW
R
ARQCLKYD--THS
E
----------------------------
K
-
IKPQAVIET
L
WR
----
LTKGDAYV
T
S
DVG
QH
QM
F
AA
LY
-
YPFDK
PR
RW
I
N
S
G
--------
GL
G
T
MG
F
GLP
A
A
L
G
V
KM
A
L
P
EET
VVC
VT
GDG
SIQ
M
NIQ
E
LS
T
AL
Q
YE
LPV
L
V
V
NL
NN
RY
LG
M
V
K
-
QWQD
M
IYSGRHSQSYMQSL
-----------
PD
F
VR
LA
E
A
Y
G
HV
G
IQ
I
SHPH
E
LES
K
L
SEALEQ
VRN
NR
L
VF
V
D
V
T
V
D
GS
--------
E
HVY
P
M
Q
IR
G
G
G
M
D
EMWLSKTERT
fig|536056.3.peg.3723
Escherichia coli DH1
MV
V
RS
L
IDQ
GV
KQ
V
F
G
YP
G
GA
V
LD
I
Y
D
A
L
HTV
-
G
G
I
D
H
V
LV
RHEQ
A
A
VHM
A
D
G
L
A
RAT
G
E
V
GV
--
V
LVT
SGPG
A
TN
A
ITG
I
A
T
A
YM
D
SI
PL
V
V
L
SG
QVATSL
IG
--
Y
D
A
FQE
C
D
MV
--------
GISRPVV
K
HSF
LV
KQT
ED
I
P
QV
L
KK
A
FWL
A
A
S
-
GRPG
P
V
V
VDLP
K
D
I
LNPANKLP
YVW
PESVSMRSYNPT-
-
-TTGHKGQ
I
KR
A
LQT
L
VA
A
KK
P
V
V
YV
G
G
G
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
VVCS
L
M
GLG
AF
P
AT
H
R
QAL
GM
L
GM
H
G
TYEANMT
M
H
NAD
V
I
FA
VG
V
RF
DD
R
TTNNLAK
Y
C
P
-
NA
TV
L
HIDIDP
T
S
I
SKTVTAD
I
P
IVGD
ARQV
L
EQ
M
L
EL
L
SQESAHQ
PL
D
EI
RD
W
W
Q
QIEQW
R
ARQCLKYD--THS
E
----------------------------
K
-
IKPQAVIET
L
WR
----
LTKGDAYV
T
S
DVG
QH
QM
F
AA
LY
-
YPFDK
PR
RW
I
N
S
G
--------
GL
G
T
MG
F
GLP
A
A
L
G
V
KM
A
L
P
EET
VVC
VT
GDG
SIQ
M
NIQ
E
LS
T
AL
Q
YE
LPV
L
V
V
NL
NN
RY
LG
M
V
K
-
QWQD
M
IYSGRHSQSYMQSL
-----------
PD
F
VR
LA
E
A
Y
G
HV
G
IQ
I
SHPH
E
LES
K
L
SEALEQ
VRN
NR
L
VF
V
D
V
T
V
D
GS
--------
E
HVY
P
M
Q
IR
G
G
G
M
D
EMWLSKTERT
fig|316401.4.peg.86
Escherichia coli ETEC H10407
MV
V
RS
L
IDQ
GV
KQ
V
F
G
YP
G
GA
V
LD
I
Y
D
A
L
HTV
-
G
G
I
D
H
V
LV
RHEQ
A
A
VHM
A
D
G
L
A
RAT
G
E
V
GV
--
V
LVT
SGPG
A
TN
A
ITG
I
A
T
A
YM
D
SI
PL
V
V
L
SG
QVATSL
IG
--
Y
D
A
FQE
C
D
MV
--------
GISRPVV
K
HSF
LV
KQT
ED
I
P
QV
L
KK
A
FWL
A
A
S
-
GRPG
P
V
V
VDLP
K
D
I
LNPANKLP
YVW
PESVSMRSYNPT-
-
-TTGHKGQ
I
KR
A
LQT
L
VA
A
KK
P
V
V
YV
G
G
G
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
VVCS
L
M
GLG
AF
P
AT
H
R
QAL
GM
L
GM
H
G
TYEANMT
M
H
NAD
V
I
FA
VG
V
RF
DD
R
TTNNLAK
Y
C
P
-
NA
TV
L
HIDIDP
T
S
I
SKTVTAD
I
P
IVGD
ARQV
L
EQ
M
L
EL
L
SQESAHQ
PL
D
EI
RD
W
W
Q
QIEQW
R
ARQCLKYD--THS
E
----------------------------
K
-
IKPQAVIET
L
WR
----
LTKGDAYV
T
S
DVG
QH
QM
F
AA
LY
-
YPFDK
PR
RW
I
N
S
G
--------
GL
G
T
MG
F
GLP
A
A
L
G
V
KM
A
L
P
EET
VVC
VT
GDG
SIQ
M
NIQ
E
LS
T
AL
Q
YE
LPV
L
V
V
NL
NN
RY
LG
M
V
K
-
QWQD
M
IYSGRHSQSYMQSL
-----------
PD
F
VR
LA
E
A
Y
G
HV
G
IQ
I
SHPH
E
LES
K
L
SEALEQ
VRN
NR
L
VF
V
D
V
T
V
D
GS
--------
E
HVY
P
M
Q
IR
G
G
G
M
D
EMWLSKTERT
fig|83333.1.peg.78
Escherichia coli K12 (9-574/574)
MV
V
RS
L
IDQ
GV
KQ
V
F
G
YP
G
GA
V
LD
I
Y
D
A
L
HTV
-
G
G
I
D
H
V
LV
RHEQ
A
A
VHM
A
D
G
L
A
RAT
G
E
V
GV
--
V
LVT
SGPG
A
TN
A
ITG
I
A
T
A
YM
D
SI
PL
V
V
L
SG
QVATSL
IG
--
Y
D
A
FQE
C
D
MV
--------
GISRPVV
K
HSF
LV
KQT
ED
I
P
QV
L
KK
A
FWL
A
A
S
-
GRPG
P
V
V
VDLP
K
D
I
LNPANKLP
YVW
PESVSMRSYNPT-
-
-TTGHKGQ
I
KR
A
LQT
L
VA
A
KK
P
V
V
YV
G
G
G
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
VVCS
L
M
GLG
AF
P
AT
H
R
QAL
GM
L
GM
H
G
TYEANMT
M
H
NAD
V
I
FA
VG
V
RF
DD
R
TTNNLAK
Y
C
P
-
NA
TV
L
HIDIDP
T
S
I
SKTVTAD
I
P
IVGD
ARQV
L
EQ
M
L
EL
L
SQESAHQ
PL
D
EI
RD
W
W
Q
QIEQW
R
ARQCLKYD--THS
E
----------------------------
K
-
IKPQAVIET
L
WR
----
LTKGDAYV
T
S
DVG
QH
QM
F
AA
LY
-
YPFDK
PR
RW
I
N
S
G
--------
GL
G
T
MG
F
GLP
A
A
L
G
V
KM
A
L
P
EET
VVC
VT
GDG
SIQ
M
NIQ
E
LS
T
AL
Q
YE
LPV
L
V
V
NL
NN
RY
LG
M
V
K
-
QWQD
M
IYSGRHSQSYMQSL
-----------
PD
F
VR
LA
E
A
Y
G
HV
G
IQ
I
SHPH
E
LES
K
L
SEALEQ
VRN
NR
L
VF
V
D
V
T
V
D
GS
--------
E
HVY
P
M
Q
IR
G
G
G
M
D
EMWLSKTERT
fig|749537.3.peg.3174
Escherichia coli MS 115-1
MV
V
RS
L
IDQ
GV
KQ
V
F
G
YP
G
GA
V
LD
I
Y
D
A
L
HTV
-
G
G
I
D
H
V
LV
RHEQ
A
A
VHM
A
D
G
L
A
RAT
G
E
V
GV
--
V
LVT
SGPG
A
TN
A
ITG
I
A
T
A
YM
D
SI
PL
V
V
L
SG
QVATSL
IG
--
Y
D
A
FQE
C
D
MV
--------
GISRPVV
K
HSF
LV
KQT
ED
I
P
QV
L
KK
A
FWL
A
A
S
-
GRPG
P
V
V
VDLP
K
D
I
LNPANKLP
YVW
PESVSMRSYNPT-
-
-TTGHKGQ
I
KR
A
LQT
L
VA
A
KK
P
V
V
YV
G
G
G
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
VVCS
L
M
GLG
AF
P
AT
H
R
QAL
GM
L
GM
H
G
TYEANMT
M
H
NAD
V
I
FA
VG
V
RF
DD
R
TTNNLAK
Y
C
P
-
NA
TV
L
HIDIDP
T
S
I
SKTVTAD
I
P
IVGD
ARQV
L
EQ
M
L
EL
L
SQESAHQ
PL
D
EI
RD
W
W
Q
QIEQW
R
ARQCLKYD--THS
E
----------------------------
K
-
IKPQAVIET
L
WR
----
LTKGDAYV
T
S
DVG
QH
QM
F
AA
LY
-
YPFDK
PR
RW
I
N
S
G
--------
GL
G
T
MG
F
GLP
A
A
L
G
V
KM
A
L
P
EET
VVC
VT
GDG
SIQ
M
NIQ
E
LS
T
AL
Q
YE
LPV
L
V
V
NL
NN
RY
LG
M
V
K
-
QWQD
M
IYSGRHSQSYMQSL
-----------
PD
F
VR
LA
E
A
Y
G
HV
G
IQ
I
SHPH
E
LES
K
L
SEALEQ
VRN
NR
L
VF
V
D
V
T
V
D
GS
--------
E
HVY
P
M
Q
IR
G
G
G
M
D
EMWLSKTERT
fig|749538.3.peg.3058
Escherichia coli MS 116-1 (9-574/574)
MV
V
RS
L
IDQ
GV
KQ
V
F
G
YP
G
GA
V
LD
I
Y
D
A
L
HTV
-
G
G
I
D
H
V
LV
RHEQ
A
A
VHM
A
D
G
L
A
RAT
G
E
V
GV
--
V
LVT
SGPG
A
TN
A
ITG
I
A
T
A
YM
D
SI
PL
V
V
L
SG
QVATSL
IG
--
Y
D
A
FQE
C
D
MV
--------
GISRPVV
K
HSF
LV
KQT
ED
I
P
QV
L
KK
A
FWL
A
A
S
-
GRPG
P
V
V
VDLP
K
D
I
LNPANKLP
YVW
PESVSMRSYNPT-
-
-TTGHKGQ
I
KR
A
LQT
L
VA
A
KK
P
V
V
YV
G
G
G
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
VVCS
L
M
GLG
AF
P
AT
H
R
QAL
GM
L
GM
H
G
TYEANMT
M
H
NAD
V
I
FA
VG
V
RF
DD
R
TTNNLAK
Y
C
P
-
NA
TV
L
HIDIDP
T
S
I
SKTVTAD
I
P
IVGD
ARQV
L
EQ
M
L
EL
L
SQESAHQ
PL
D
EI
RD
W
W
Q
QIEQW
R
ARQCLKYD--THS
E
----------------------------
K
-
IKPQAVIET
L
WR
----
LTKGDAYV
T
S
DVG
QH
QM
F
AA
LY
-
YPFDK
PR
RW
I
N
S
G
--------
GL
G
T
MG
F
GLP
A
A
L
G
V
KM
A
L
P
EET
VVC
VT
GDG
SIQ
M
NIQ
E
LS
T
AL
Q
YE
LPV
L
V
V
NL
NN
RY
LG
M
V
K
-
QWQD
M
IYSGRHSQSYMQSL
-----------
PD
F
VR
LA
E
A
Y
G
HV
G
IQ
I
SHPH
E
LES
K
L
SEALEQ
VRN
NR
L
VF
V
D
V
T
V
D
GS
--------
E
HVY
P
M
Q
IR
G
G
G
M
D
EMWLSKTERT
fig|749540.3.peg.2853
Escherichia coli MS 146-1
MV
V
RS
L
IDQ
GV
KQ
V
F
G
YP
G
GA
V
LD
I
Y
D
A
L
HTV
-
G
G
I
D
H
V
LV
RHEQ
A
A
VHM
A
D
G
L
A
RAT
G
E
V
GV
--
V
LVT
SGPG
A
TN
A
ITG
I
A
T
A
YM
D
SI
PL
V
V
L
SG
QVATSL
IG
--
Y
D
A
FQE
C
D
MV
--------
GISRPVV
K
HSF
LV
KQT
ED
I
P
QV
L
KK
A
FWL
A
A
S
-
GRPG
P
V
V
VDLP
K
D
I
LNPANKLP
YVW
PESVSMRSYNPT-
-
-TTGHKGQ
I
KR
A
LQT
L
VA
A
KK
P
V
V
YV
G
G
G
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
VVCS
L
M
GLG
AF
P
AT
H
R
QAL
GM
L
GM
H
G
TYEANMT
M
H
NAD
V
I
FA
VG
V
RF
DD
R
TTNNLAK
Y
C
P
-
NA
TV
L
HIDIDP
T
S
I
SKTVTAD
I
P
IVGD
ARQV
L
EQ
M
L
EL
L
SQESAHQ
PL
D
EI
RD
W
W
Q
QIEQW
R
ARQCLKYD--THS
E
----------------------------
K
-
IKPQAVIET
L
WR
----
LTKGDAYV
T
S
DVG
QH
QM
F
AA
LY
-
YPFDK
PR
RW
I
N
S
G
--------
GL
G
T
MG
F
GLP
A
A
L
G
V
KM
A
L
P
EET
VVC
VT
GDG
SIQ
M
NIQ
E
LS
T
AL
Q
YE
LPV
L
V
V
NL
NN
RY
LG
M
V
K
-
QWQD
M
IYSGRHSQSYMQSL
-----------
PD
F
VR
LA
E
A
Y
G
HV
G
IQ
I
SHPH
E
LES
K
L
SEALEQ
VRN
NR
L
VF
V
D
V
T
V
D
GS
--------
E
HVY
P
M
Q
IR
G
G
G
M
D
EMWLSKTERT
fig|749544.3.peg.1715
Escherichia coli MS 175-1
MV
V
RS
L
IDQ
GV
KQ
V
F
G
YP
G
GA
V
LD
I
Y
D
A
L
HTV
-
G
G
I
D
H
V
LV
RHEQ
A
A
VHM
A
D
G
L
A
RAT
G
E
V
GV
--
V
LVT
SGPG
A
TN
A
ITG
I
A
T
A
YM
D
SI
PL
V
V
L
SG
QVATSL
IG
--
Y
D
A
FQE
C
D
MV
--------
GISRPVV
K
HSF
LV
KQT
ED
I
P
QV
L
KK
A
FWL
A
A
S
-
GRPG
P
V
V
VDLP
K
D
I
LNPANKLP
YVW
PESVSMRSYNPT-
-
-TTGHKGQ
I
KR
A
LQT
L
VA
A
KK
P
V
V
YV
G
G
G
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
VVCS
L
M
GLG
AF
P
AT
H
R
QAL
GM
L
GM
H
G
TYEANMT
M
H
NAD
V
I
FA
VG
V
RF
DD
R
TTNNLAK
Y
C
P
-
NA
TV
L
HIDIDP
T
S
I
SKTVTAD
I
P
IVGD
ARQV
L
EQ
M
L
EL
L
SQESAHQ
PL
D
EI
RD
W
W
Q
QIEQW
R
ARQCLKYD--THS
E
----------------------------
K
-
IKPQAVIET
L
WR
----
LTKGDAYV
T
S
DVG
QH
QM
F
AA
LY
-
YPFDK
PR
RW
I
N
S
G
--------
GL
G
T
MG
F
GLP
A
A
L
G
V
KM
A
L
P
EET
VVC
VT
GDG
SIQ
M
NIQ
E
LS
T
AL
Q
YE
LPV
L
V
V
NL
NN
RY
LG
M
V
K
-
QWQD
M
IYSGRHSQSYMQSL
-----------
PD
F
VR
LA
E
A
Y
G
HV
G
IQ
I
SHPH
E
LES
K
L
SEALEQ
VRN
NR
L
VF
V
D
V
T
V
D
GS
--------
E
HVY
P
M
Q
IR
G
G
G
M
D
EMWLSKTERT
fig|749548.3.peg.4247
Escherichia coli MS 196-1
MV
V
RS
L
IDQ
GV
KQ
V
F
G
YP
G
GA
V
LD
I
Y
D
A
L
HTV
-
G
G
I
D
H
V
LV
RHEQ
A
A
VHM
A
D
G
L
A
RAT
G
E
V
GV
--
V
LVT
SGPG
A
TN
A
ITG
I
A
T
A
YM
D
SI
PL
V
V
L
SG
QVATSL
IG
--
Y
D
A
FQE
C
D
MV
--------
GISRPVV
K
HSF
LV
KQT
ED
I
P
QV
L
KK
A
FWL
A
A
S
-
GRPG
P
V
V
VDLP
K
D
I
LNPANKLP
YVW
PESVSMRSYNPT-
-
-TTGHKGQ
I
KR
A
LQT
L
VA
A
KK
P
V
V
YV
G
G
G
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
VVCS
L
M
GLG
AF
P
AT
H
R
QAL
GM
L
GM
H
G
TYEANMT
M
H
NAD
V
I
FA
VG
V
RF
DD
R
TTNNLAK
Y
C
P
-
NA
TV
L
HIDIDP
T
S
I
SKTVTAD
I
P
IVGD
ARQV
L
EQ
M
L
EL
L
SQESAHQ
PL
D
EI
RD
W
W
Q
QIEQW
R
ARQCLKYD--THS
E
----------------------------
K
-
IKPQAVIET
L
WR
----
LTKGDAYV
T
S
DVG
QH
QM
F
AA
LY
-
YPFDK
PR
RW
I
N
S
G
--------
GL
G
T
MG
F
GLP
A
A
L
G
V
KM
A
L
P
EET
VVC
VT
GDG
SIQ
M
NIQ
E
LS
T
AL
Q
YE
LPV
L
V
V
NL
NN
RY
LG
M
V
K
-
QWQD
M
IYSGRHSQSYMQSL
-----------
PD
F
VR
LA
E
A
Y
G
HV
G
IQ
I
SHPH
E
LES
K
L
SEALEQ
VRN
NR
L
VF
V
D
V
T
V
D
GS
--------
E
HVY
P
M
Q
IR
G
G
G
M
D
EMWLSKTERT
fig|316407.3.peg.77
Escherichia coli W3110 (9-574/574)
MV
V
RS
L
IDQ
GV
KQ
V
F
G
YP
G
GA
V
LD
I
Y
D
A
L
HTV
-
G
G
I
D
H
V
LV
RHEQ
A
A
VHM
A
D
G
L
A
RAT
G
E
V
GV
--
V
LVT
SGPG
A
TN
A
ITG
I
A
T
A
YM
D
SI
PL
V
V
L
SG
QVATSL
IG
--
Y
D
A
FQE
C
D
MV
--------
GISRPVV
K
HSF
LV
KQT
ED
I
P
QV
L
KK
A
FWL
A
A
S
-
GRPG
P
V
V
VDLP
K
D
I
LNPANKLP
YVW
PESVSMRSYNPT-
-
-TTGHKGQ
I
KR
A
LQT
L
VA
A
KK
P
V
V
YV
G
G
G
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
VVCS
L
M
GLG
AF
P
AT
H
R
QAL
GM
L
GM
H
G
TYEANMT
M
H
NAD
V
I
FA
VG
V
RF
DD
R
TTNNLAK
Y
C
P
-
NA
TV
L
HIDIDP
T
S
I
SKTVTAD
I
P
IVGD
ARQV
L
EQ
M
L
EL
L
SQESAHQ
PL
D
EI
RD
W
W
Q
QIEQW
R
ARQCLKYD--THS
E
----------------------------
K
-
IKPQAVIET
L
WR
----
LTKGDAYV
T
S
DVG
QH
QM
F
AA
LY
-
YPFDK
PR
RW
I
N
S
G
--------
GL
G
T
MG
F
GLP
A
A
L
G
V
KM
A
L
P
EET
VVC
VT
GDG
SIQ
M
NIQ
E
LS
T
AL
Q
YE
LPV
L
V
V
NL
NN
RY
LG
M
V
K
-
QWQD
M
IYSGRHSQSYMQSL
-----------
PD
F
VR
LA
E
A
Y
G
HV
G
IQ
I
SHPH
E
LES
K
L
SEALEQ
VRN
NR
L
VF
V
D
V
T
V
D
GS
--------
E
HVY
P
M
Q
IR
G
G
G
M
D
EMWLSKTERT
fig|511145.12.peg.80
Escherichia coli str. K-12 substr. MG1655
MV
V
RS
L
IDQ
GV
KQ
V
F
G
YP
G
GA
V
LD
I
Y
D
A
L
HTV
-
G
G
I
D
H
V
LV
RHEQ
A
A
VHM
A
D
G
L
A
RAT
G
E
V
GV
--
V
LVT
SGPG
A
TN
A
ITG
I
A
T
A
YM
D
SI
PL
V
V
L
SG
QVATSL
IG
--
Y
D
A
FQE
C
D
MV
--------
GISRPVV
K
HSF
LV
KQT
ED
I
P
QV
L
KK
A
FWL
A
A
S
-
GRPG
P
V
V
VDLP
K
D
I
LNPANKLP
YVW
PESVSMRSYNPT-
-
-TTGHKGQ
I
KR
A
LQT
L
VA
A
KK
P
V
V
YV
G
G
G
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
VVCS
L
M
GLG
AF
P
AT
H
R
QAL
GM
L
GM
H
G
TYEANMT
M
H
NAD
V
I
FA
VG
V
RF
DD
R
TTNNLAK
Y
C
P
-
NA
TV
L
HIDIDP
T
S
I
SKTVTAD
I
P
IVGD
ARQV
L
EQ
M
L
EL
L
SQESAHQ
PL
D
EI
RD
W
W
Q
QIEQW
R
ARQCLKYD--THS
E
----------------------------
K
-
IKPQAVIET
L
WR
----
LTKGDAYV
T
S
DVG
QH
QM
F
AA
LY
-
YPFDK
PR
RW
I
N
S
G
--------
GL
G
T
MG
F
GLP
A
A
L
G
V
KM
A
L
P
EET
VVC
VT
GDG
SIQ
M
NIQ
E
LS
T
AL
Q
YE
LPV
L
V
V
NL
NN
RY
LG
M
V
K
-
QWQD
M
IYSGRHSQSYMQSL
-----------
PD
F
VR
LA
E
A
Y
G
HV
G
IQ
I
SHPH
E
LES
K
L
SEALEQ
VRN
NR
L
VF
V
D
V
T
V
D
GS
--------
E
HVY
P
M
Q
IR
G
G
G
M
D
EMWLSKTERT
fig|511145.6.peg.81
Escherichia coli str. K-12 substr. MG1655
MV
V
RS
L
IDQ
GV
KQ
V
F
G
YP
G
GA
V
LD
I
Y
D
A
L
HTV
-
G
G
I
D
H
V
LV
RHEQ
A
A
VHM
A
D
G
L
A
RAT
G
E
V
GV
--
V
LVT
SGPG
A
TN
A
ITG
I
A
T
A
YM
D
SI
PL
V
V
L
SG
QVATSL
IG
--
Y
D
A
FQE
C
D
MV
--------
GISRPVV
K
HSF
LV
KQT
ED
I
P
QV
L
KK
A
FWL
A
A
S
-
GRPG
P
V
V
VDLP
K
D
I
LNPANKLP
YVW
PESVSMRSYNPT-
-
-TTGHKGQ
I
KR
A
LQT
L
VA
A
KK
P
V
V
YV
G
G
G
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
VVCS
L
M
GLG
AF
P
AT
H
R
QAL
GM
L
GM
H
G
TYEANMT
M
H
NAD
V
I
FA
VG
V
RF
DD
R
TTNNLAK
Y
C
P
-
NA
TV
L
HIDIDP
T
S
I
SKTVTAD
I
P
IVGD
ARQV
L
EQ
M
L
EL
L
SQESAHQ
PL
D
EI
RD
W
W
Q
QIEQW
R
ARQCLKYD--THS
E
----------------------------
K
-
IKPQAVIET
L
WR
----
LTKGDAYV
T
S
DVG
QH
QM
F
AA
LY
-
YPFDK
PR
RW
I
N
S
G
--------
GL
G
T
MG
F
GLP
A
A
L
G
V
KM
A
L
P
EET
VVC
VT
GDG
SIQ
M
NIQ
E
LS
T
AL
Q
YE
LPV
L
V
V
NL
NN
RY
LG
M
V
K
-
QWQD
M
IYSGRHSQSYMQSL
-----------
PD
F
VR
LA
E
A
Y
G
HV
G
IQ
I
SHPH
E
LES
K
L
SEALEQ
VRN
NR
L
VF
V
D
V
T
V
D
GS
--------
E
HVY
P
M
Q
IR
G
G
G
M
D
EMWLSKTERT
fig|358709.5.peg.4139
Escherichia coli 101-1
MV
V
RS
L
IDQ
GV
KQ
V
F
G
YP
G
GA
V
LD
I
Y
D
A
L
HTV
-
G
G
I
D
H
V
LV
RHEQ
A
A
VHM
A
D
G
L
A
RAT
G
E
V
GV
--
V
LVT
SGPG
A
TN
A
ITG
I
A
T
A
YM
D
SI
PL
V
V
L
SG
QVATSL
IG
--
Y
D
A
FQE
C
D
MV
--------
GISRPVV
K
HSF
LV
KQT
ED
I
P
QV
L
KK
A
FWL
A
A
S
-
GRPG
P
V
V
VDLP
K
D
I
LNPANKLP
YVW
PESVSMRSYNPT-
-
-TTGHKGQ
I
KR
A
LQT
L
VA
A
KK
P
V
V
YV
G
G
G
AIT
A
G
C
HQQ
L
K
E
MVEALNL
P
VVSS
L
M
GLG
AF
P
AT
H
R
QAL
GM
L
GM
H
G
TYEANMT
M
H
NAD
V
I
FA
VG
V
RF
DD
R
TTNNLAK
Y
C
P
-
NA
TV
L
HIDIDP
T
S
I
SKTVTAD
I
P
IVGD
ARQV
L
EQ
M
L
EL
L
SQESAHQ
PL
D
EI
RD
W
W
Q
QIEQW
R
ARQCLKYD--THS
E
----------------------------
K
-
IKPQAVIET
L
WR
----
LTKGDAYV
T
S
DVG
QH
QM
F
AA
LY
-
YPFDK
PR
RW
I
N
S
G
--------
GL
G
T
MG
F
GLP
A
A
L
G
V
KM
A
L
P
EET
VVC
VT
GDG
SIQ
M
NIQ
E
LS
T
AL
Q
YE
LPV
L
V
V
NL
NN
RY
LG
M
V
K
-
QWQD
M
IYSGRHSQSYMQSL
-----------
PD
F
VR
LA
E
A
Y
G
HV
G
IQ
I
SHPH
E
LES
K
L
SEALEQ
VRN
NR
L
VF
V
D
V
T
V
D
GS
--------
E
HVY
P
M
Q
IR
G
G
G
M
D
EMWLSKTERT
fig|413997.3.peg.84
Escherichia coli B str. REL606
MV
V
RS
L
IDQ
GV
KQ
V
F
G
YP
G
GA
V
LD
I
Y
D
A
L
HTV
-
G
G
I
D
H
V
LV
RHEQ
A
A
VHM
A
D
G
L
A
RAT
G
E
V
GV
--
V
LVT
SGPG
A
TN
A
ITG
I
A
T
A
YM
D
SI
PL
V
V
L
SG
QVATSL
IG
--
Y
D
A
FQE
C
D
MV
--------
GISRPVV
K
HSF
LV
KQT
ED
I
P
QV
L
KK
A
FWL
A
A
S
-
GRPG
P
V
V
VDLP
K
D
I
LNPANKLP
YVW
PESVSMRSYNPT-
-
-TTGHKGQ
I
KR
A
LQT
L
VA
A
KK
P
V
V
YV
G
G
G
AIT
A
G
C
HQQ
L
K
E
MVEALNL
P
VVSS
L
M
GLG
AF
P
AT
H
R
QAL
GM
L
GM
H
G
TYEANMT
M
H
NAD
V
I
FA
VG
V
RF
DD
R
TTNNLAK
Y
C
P
-
NA
TV
L
HIDIDP
T
S
I
SKTVTAD
I
P
IVGD
ARQV
L
EQ
M
L
EL
L
SQESAHQ
PL
D
EI
RD
W
W
Q
QIEQW
R
ARQCLKYD--THS
E
----------------------------
K
-
IKPQAVIET
L
WR
----
LTKGDAYV
T
S
DVG
QH
QM
F
AA
LY
-
YPFDK
PR
RW
I
N
S
G
--------
GL
G
T
MG
F
GLP
A
A
L
G
V
KM
A
L
P
EET
VVC
VT
GDG
SIQ
M
NIQ
E
LS
T
AL
Q
YE
LPV
L
V
V
NL
NN
RY
LG
M
V
K
-
QWQD
M
IYSGRHSQSYMQSL
-----------
PD
F
VR
LA
E
A
Y
G
HV
G
IQ
I
SHPH
E
LES
K
L
SEALEQ
VRN
NR
L
VF
V
D
V
T
V
D
GS
--------
E
HVY
P
M
Q
IR
G
G
G
M
D
EMWLSKTERT
fig|511693.5.peg.85
Escherichia coli BL21
MV
V
RS
L
IDQ
GV
KQ
V
F
G
YP
G
GA
V
LD
I
Y
D
A
L
HTV
-
G
G
I
D
H
V
LV
RHEQ
A
A
VHM
A
D
G
L
A
RAT
G
E
V
GV
--
V
LVT
SGPG
A
TN
A
ITG
I
A
T
A
YM
D
SI
PL
V
V
L
SG
QVATSL
IG
--
Y
D
A
FQE
C
D
MV
--------
GISRPVV
K
HSF
LV
KQT
ED
I
P
QV
L
KK
A
FWL
A
A
S
-
GRPG
P
V
V
VDLP
K
D
I
LNPANKLP
YVW
PESVSMRSYNPT-
-
-TTGHKGQ
I
KR
A
LQT
L
VA
A
KK
P
V
V
YV
G
G
G
AIT
A
G
C
HQQ
L
K
E
MVEALNL
P
VVSS
L
M
GLG
AF
P
AT
H
R
QAL
GM
L
GM
H
G
TYEANMT
M
H
NAD
V
I
FA
VG
V
RF
DD
R
TTNNLAK
Y
C
P
-
NA
TV
L
HIDIDP
T
S
I
SKTVTAD
I
P
IVGD
ARQV
L
EQ
M
L
EL
L
SQESAHQ
PL
D
EI
RD
W
W
Q
QIEQW
R
ARQCLKYD--THS
E
----------------------------
K
-
IKPQAVIET
L
WR
----
LTKGDAYV
T
S
DVG
QH
QM
F
AA
LY
-
YPFDK
PR
RW
I
N
S
G
--------
GL
G
T
MG
F
GLP
A
A
L
G
V
KM
A
L
P
EET
VVC
VT
GDG
SIQ
M
NIQ
E
LS
T
AL
Q
YE
LPV
L
V
V
NL
NN
RY
LG
M
V
K
-
QWQD
M
IYSGRHSQSYMQSL
-----------
PD
F
VR
LA
E
A
Y
G
HV
G
IQ
I
SHPH
E
LES
K
L
SEALEQ
VRN
NR
L
VF
V
D
V
T
V
D
GS
--------
E
HVY
P
M
Q
IR
G
G
G
M
D
EMWLSKTERT
fig|469008.4.peg.3660
Escherichia coli BL21(DE3)
MV
V
RS
L
IDQ
GV
KQ
V
F
G
YP
G
GA
V
LD
I
Y
D
A
L
HTV
-
G
G
I
D
H
V
LV
RHEQ
A
A
VHM
A
D
G
L
A
RAT
G
E
V
GV
--
V
LVT
SGPG
A
TN
A
ITG
I
A
T
A
YM
D
SI
PL
V
V
L
SG
QVATSL
IG
--
Y
D
A
FQE
C
D
MV
--------
GISRPVV
K
HSF
LV
KQT
ED
I
P
QV
L
KK
A
FWL
A
A
S
-
GRPG
P
V
V
VDLP
K
D
I
LNPANKLP
YVW
PESVSMRSYNPT-
-
-TTGHKGQ
I
KR
A
LQT
L
VA
A
KK
P
V
V
YV
G
G
G
AIT
A
G
C
HQQ
L
K
E
MVEALNL
P
VVSS
L
M
GLG
AF
P
AT
H
R
QAL
GM
L
GM
H
G
TYEANMT
M
H
NAD
V
I
FA
VG
V
RF
DD
R
TTNNLAK
Y
C
P
-
NA
TV
L
HIDIDP
T
S
I
SKTVTAD
I
P
IVGD
ARQV
L
EQ
M
L
EL
L
SQESAHQ
PL
D
EI
RD
W
W
Q
QIEQW
R
ARQCLKYD--THS
E
----------------------------
K
-
IKPQAVIET
L
WR
----
LTKGDAYV
T
S
DVG
QH
QM
F
AA
LY
-
YPFDK
PR
RW
I
N
S
G
--------
GL
G
T
MG
F
GLP
A
A
L
G
V
KM
A
L
P
EET
VVC
VT
GDG
SIQ
M
NIQ
E
LS
T
AL
Q
YE
LPV
L
V
V
NL
NN
RY
LG
M
V
K
-
QWQD
M
IYSGRHSQSYMQSL
-----------
PD
F
VR
LA
E
A
Y
G
HV
G
IQ
I
SHPH
E
LES
K
L
SEALEQ
VRN
NR
L
VF
V
D
V
T
V
D
GS
--------
E
HVY
P
M
Q
IR
G
G
G
M
D
EMWLSKTERT
fig|595496.3.peg.82
Escherichia coli BW2952
MV
V
RS
L
IDQ
GV
KQ
V
F
G
YP
G
GA
V
LD
I
Y
D
A
L
HTV
-
G
G
I
D
H
V
LV
RHEQ
A
A
VHM
A
D
G
L
A
RAT
G
E
V
GV
--
V
LVT
SGPG
A
TN
A
ITG
I
A
T
A
YM
D
SI
PL
V
V
L
SG
QVATSL
IG
--
Y
D
A
FQE
C
D
MV
--------
GISRPVV
K
HSF
LV
KQT
ED
I
P
QV
L
KK
A
FWL
A
A
S
-
GRPG
P
V
V
VDLP
K
D
I
LNPANKLP
YVW
PESVSMRSYNPT-
-
-TTGHKGQ
I
KR
A
LQT
L
VA
A
KK
P
V
V
YV
G
G
G
AIT
A
G
C
HQQ
L
K
E
MVEALNL
P
VVSS
L
M
GLG
AF
P
AT
H
R
QAL
GM
L
GM
H
G
TYEANMT
M
H
NAD
V
I
FA
VG
V
RF
DD
R
TTNNLAK
Y
C
P
-
NA
TV
L
HIDIDP
T
S
I
SKTVTAD
I
P
IVGD
ARQV
L
EQ
M
L
EL
L
SQESAHQ
PL
D
EI
RD
W
W
Q
QIEQW
R
ARQCLKYD--THS
E
----------------------------
K
-
IKPQAVIET
L
WR
----
LTKGDAYV
T
S
DVG
QH
QM
F
AA
LY
-
YPFDK
PR
RW
I
N
S
G
--------
GL
G
T
MG
F
GLP
A
A
L
G
V
KM
A
L
P
EET
VVC
VT
GDG
SIQ
M
NIQ
E
LS
T
AL
Q
YE
LPV
L
V
V
NL
NN
RY
LG
M
V
K
-
QWQD
M
IYSGRHSQSYMQSL
-----------
PD
F
VR
LA
E
A
Y
G
HV
G
IQ
I
SHPH
E
LES
K
L
SEALEQ
VRN
NR
L
VF
V
D
V
T
V
D
GS
--------
E
HVY
P
M
Q
IR
G
G
G
M
D
EMWLSKTERT
fig|749547.3.peg.3862
Escherichia coli MS 187-1
MV
V
RS
L
IDQ
GV
KQ
V
F
G
YP
G
GA
V
LD
I
Y
D
A
L
HTV
-
G
G
I
D
H
V
LV
RHEQ
A
A
VHM
A
D
G
L
A
RAT
G
E
V
GV
--
V
LVT
SGPG
A
TN
A
ITG
I
A
T
A
YM
D
SI
PL
V
V
L
SG
QVATSL
IG
--
Y
D
A
FQE
C
D
MV
--------
GISRPVV
K
HSF
LV
KQT
ED
I
P
QV
L
KK
A
FWL
A
A
S
-
GRPG
P
V
V
VDLP
K
D
I
LNPANKLP
YVW
PESVSMRSYNPT-
-
-TTGHKGQ
I
KR
A
LQT
L
VA
A
KK
P
V
V
YV
G
G
G
AIT
A
G
C
HQQ
L
K
E
MVEALNL
P
VVSS
L
M
GLG
AF
P
AT
H
R
QAL
GM
L
GM
H
G
TYEANMT
M
H
NAD
V
I
FA
VG
V
RF
DD
R
TTNNLAK
Y
C
P
-
NA
TV
L
HIDIDP
T
S
I
SKTVTAD
I
P
IVGD
ARQV
L
EQ
M
L
EL
L
SQESAHQ
PL
D
EI
RD
W
W
Q
QIEQW
R
ARQCLKYD--THS
E
----------------------------
K
-
IKPQAVIET
L
WR
----
LTKGDAYV
T
S
DVG
QH
QM
F
AA
LY
-
YPFDK
PR
RW
I
N
S
G
--------
GL
G
T
MG
F
GLP
A
A
L
G
V
KM
A
L
P
EET
VVC
VT
GDG
SIQ
M
NIQ
E
LS
T
AL
Q
YE
LPV
L
V
V
NL
NN
RY
LG
M
V
K
-
QWQD
M
IYSGRHSQSYMQSL
-----------
PD
F
VR
LA
E
A
Y
G
HV
G
IQ
I
SHPH
E
LES
K
L
SEALEQ
VRN
NR
L
VF
V
D
V
T
V
D
GS
--------
E
HVY
P
M
Q
IR
G
G
G
M
D
EMWLSKTERT
fig|679207.4.peg.1118
Escherichia coli MS 107-1
MV
V
RS
L
IDQ
GV
KQ
V
F
G
YP
G
GA
V
LD
I
Y
D
A
L
HTV
-
G
G
I
D
H
V
LV
RHEQ
A
A
VHM
A
D
G
L
A
RAT
G
E
V
GV
--
V
LVT
SGPG
A
TN
A
ITG
I
A
T
A
YM
D
SI
PL
V
V
L
SG
QVATSL
IG
--
Y
D
A
FQE
C
D
MV
--------
GISRPVV
K
HSF
LV
KQT
ED
I
P
QV
L
KK
A
FWL
A
A
S
-
GRPG
P
V
V
VDLP
K
D
I
LNPANKLP
YVW
PESVSMRSYNPT-
-
-TTGHKGQ
I
KR
A
LQT
L
VA
A
KK
P
V
V
YV
G
G
G
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
VVSS
L
M
GLG
AF
P
AT
H
R
QAL
GM
L
GM
H
G
TYEANMT
M
H
NAD
V
I
FA
VG
V
RF
DD
R
TTNNLAK
Y
C
P
-
NA
TV
L
HIDIDP
T
S
I
SKTVTAD
I
P
IVGD
ARQV
L
EQ
M
L
EL
L
SQESAHQ
PL
D
EI
CD
W
W
Q
QIEQW
R
ARQCLKYD--THS
E
----------------------------
K
-
IKPQAVIET
L
WR
----
LTKGDAYV
T
S
DVG
QH
QM
F
AA
LY
-
YPFDK
PR
RW
I
N
S
G
--------
GL
G
T
MG
F
GLP
A
A
L
G
V
KM
A
L
P
EET
VVC
VT
GDG
SIQ
M
NIQ
E
LS
T
AL
Q
YE
LPV
L
V
V
NL
NN
RY
LG
M
V
K
-
QWQD
M
IYSGRHSQSYMQSL
-----------
PD
F
VR
LA
E
A
Y
G
HV
G
IQ
I
SHPH
E
LES
K
L
SEALEQ
VRN
NR
L
VF
V
D
V
T
V
D
GS
--------
E
HVY
P
M
Q
IR
G
G
G
M
D
EMWLSKTERT
fig|656414.3.peg.198
Escherichia coli H736
MV
V
RS
L
IDQ
GV
KQ
V
F
G
YP
G
GA
V
LD
I
Y
D
A
L
HTV
-
G
G
I
D
H
V
LV
RHEQ
A
A
VHM
A
D
G
L
A
RAT
G
E
V
GV
--
V
LVT
SGPG
A
TN
A
ITG
I
A
T
A
YM
D
SI
PL
V
V
L
SG
QVATSL
IG
--
Y
D
A
FQE
C
D
MV
--------
GISRPVV
K
HSF
LV
KQT
ED
I
P
QV
L
KK
A
FWL
A
A
S
-
GRPG
P
V
V
VDLP
K
D
I
LNPANKLP
YVW
PESVSMRSYNPT-
-
-TTGHKGQ
I
KR
A
LQT
L
VA
A
KK
P
V
V
YV
G
G
G
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
VVCS
L
M
GLG
AF
P
AT
H
R
QAL
GM
L
GM
H
G
TYEANMT
M
H
NAD
V
I
FA
VG
V
RF
DD
R
TTNNLAK
Y
C
P
-
NA
TV
L
HIDIDP
T
S
I
SKTVTAD
I
P
IVGD
ARQV
L
EQ
M
L
EL
L
SQESAHQ
PL
D
EI
RD
W
W
Q
QIEQW
R
ARQCLKYD--THS
E
----------------------------
K
-
IKPQAVIET
L
WQ
----
LTKGDAYV
T
S
DVG
QH
QM
F
AA
LY
-
YPFDK
PR
RW
I
N
S
G
--------
GL
G
T
MG
F
GLP
A
A
L
G
V
KM
A
L
P
EET
VVC
VT
GDG
SIQ
M
NIQ
E
LS
T
AL
Q
YE
LPV
L
V
V
NL
NN
RY
LG
M
V
K
-
QWQD
M
IYSGRHSQSYMQSL
-----------
PD
F
VR
LA
E
A
Y
G
HV
G
IQ
I
SHPH
E
LES
K
L
SEALEQ
VRN
NR
L
VF
V
D
V
T
V
D
GS
--------
E
HVY
P
M
Q
IR
G
G
G
M
D
EMWLSKTERT
fig|656417.3.peg.141
Escherichia coli M605
MV
V
RS
L
IDQ
GV
KQ
V
F
G
YP
G
GA
V
LD
I
Y
D
A
L
HTV
-
G
G
I
D
H
V
LV
RHEQ
A
A
VHM
A
D
G
L
A
RAT
G
E
V
GV
--
V
LVT
SGPG
A
TN
A
ITG
I
A
T
A
YM
D
SI
PL
V
V
L
SG
QVATSL
IG
--
Y
D
A
FQE
C
D
MV
--------
GISRPVV
K
HSF
LV
KQT
ED
I
P
QV
L
KK
A
FWL
A
A
S
-
GRPG
P
V
V
VDLP
K
D
I
LNPANKLP
YVW
PESVSMRSYNPT-
-
-TTGHKGQ
I
KR
A
LQT
L
VA
A
KK
P
V
V
YV
G
G
G
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
VVSS
L
M
GLG
AF
P
AT
H
R
QAL
GM
L
GM
H
G
TYEANMT
M
H
NAD
V
I
FA
VG
V
RF
DD
R
TTNNLAK
Y
C
P
-
NA
TV
L
HIDIDP
T
S
I
SKTVTAD
I
P
IVGD
ARQV
L
EQ
M
L
EL
L
SQESVHQ
PL
D
EI
RD
W
W
Q
QIEQW
R
ARQCLKYD--SHS
E
----------------------------
K
-
IKPQAVIET
L
WR
----
LTKGDAYV
T
S
DVG
QH
QM
F
AA
LY
-
YPFDK
PR
RW
I
N
S
G
--------
GL
G
T
MG
F
GLP
A
A
L
G
V
KM
A
L
P
EET
VVC
VT
GDG
SIQ
M
NIQ
E
LS
T
AL
Q
YE
LPV
L
V
V
NL
NN
RY
LG
M
V
K
-
QWQD
M
IYSGRHSQSYMQSL
-----------
PD
F
VR
LA
E
A
Y
G
HV
G
IQ
I
SHPQ
E
LES
K
L
SEALEQ
VRN
NR
L
VF
V
D
V
T
V
D
GS
--------
E
HVY
P
M
Q
IR
G
G
G
M
D
EMWLSKTERT
fig|585057.4.peg.90
Escherichia coli IAI39
MV
V
RS
L
IDQ
GV
KQ
V
F
G
YP
G
GA
V
LD
I
Y
D
A
L
HTV
-
G
G
I
D
H
V
LV
RHEQ
A
A
VHM
A
D
G
L
A
RAT
G
E
V
GV
--
V
LVT
SGPG
A
TN
A
ITG
I
A
T
A
YM
D
SI
PL
V
V
L
SG
QVATSL
IG
--
Y
D
A
FQE
C
D
MV
--------
GISRPVV
K
HSF
LV
KQT
ED
I
P
QV
L
KK
A
FWL
A
A
S
-
GRPG
P
V
V
VDLP
K
D
I
LNPANKLP
YVW
PESVSMRSYNPT-
-
-TSGHKGQ
I
KR
A
LQT
L
VA
A
KK
P
V
V
YV
G
G
G
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
VVSS
L
M
GLG
AF
P
AT
H
R
QAL
GM
L
GM
H
G
TYEANMT
M
H
NAD
V
I
FA
VG
V
RF
DD
R
TTNNLAK
Y
C
P
-
NA
TV
L
HIDIDP
T
S
I
SKTVTAD
I
P
IVGD
ARQV
L
EQ
M
L
EL
L
SQESVHQ
PL
D
EI
RD
W
W
Q
QIEQW
R
ARQCLKYD--SHS
E
----------------------------
K
-
IKPQAVIET
L
WR
----
LTKGDAYV
T
S
DVG
QH
QM
F
AA
LY
-
YPFDK
PR
RW
I
N
S
G
--------
GL
G
T
MG
F
GLP
A
A
L
G
V
KM
A
L
P
EET
VVC
VT
GDG
SIQ
M
NIQ
E
LS
T
AL
Q
YE
LPV
L
V
V
NL
NN
RY
LG
M
V
K
-
QWQD
M
IYSGRHSQSYMQSL
-----------
PD
F
VR
LA
E
A
Y
G
HV
G
IQ
I
SHPQ
E
LES
K
L
SEALEQ
VRN
NR
L
VF
V
D
V
T
V
D
GS
--------
E
HVY
P
M
Q
IR
G
G
G
M
D
EMWLSKTERT
fig|585057.6.peg.89
Escherichia coli IAI39
MV
V
RS
L
IDQ
GV
KQ
V
F
G
YP
G
GA
V
LD
I
Y
D
A
L
HTV
-
G
G
I
D
H
V
LV
RHEQ
A
A
VHM
A
D
G
L
A
RAT
G
E
V
GV
--
V
LVT
SGPG
A
TN
A
ITG
I
A
T
A
YM
D
SI
PL
V
V
L
SG
QVATSL
IG
--
Y
D
A
FQE
C
D
MV
--------
GISRPVV
K
HSF
LV
KQT
ED
I
P
QV
L
KK
A
FWL
A
A
S
-
GRPG
P
V
V
VDLP
K
D
I
LNPANKLP
YVW
PESVSMRSYNPT-
-
-TSGHKGQ
I
KR
A
LQT
L
VA
A
KK
P
V
V
YV
G
G
G
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
VVSS
L
M
GLG
AF
P
AT
H
R
QAL
GM
L
GM
H
G
TYEANMT
M
H
NAD
V
I
FA
VG
V
RF
DD
R
TTNNLAK
Y
C
P
-
NA
TV
L
HIDIDP
T
S
I
SKTVTAD
I
P
IVGD
ARQV
L
EQ
M
L
EL
L
SQESVHQ
PL
D
EI
RD
W
W
Q
QIEQW
R
ARQCLKYD--SHS
E
----------------------------
K
-
IKPQAVIET
L
WR
----
LTKGDAYV
T
S
DVG
QH
QM
F
AA
LY
-
YPFDK
PR
RW
I
N
S
G
--------
GL
G
T
MG
F
GLP
A
A
L
G
V
KM
A
L
P
EET
VVC
VT
GDG
SIQ
M
NIQ
E
LS
T
AL
Q
YE
LPV
L
V
V
NL
NN
RY
LG
M
V
K
-
QWQD
M
IYSGRHSQSYMQSL
-----------
PD
F
VR
LA
E
A
Y
G
HV
G
IQ
I
SHPQ
E
LES
K
L
SEALEQ
VRN
NR
L
VF
V
D
V
T
V
D
GS
--------
E
HVY
P
M
Q
IR
G
G
G
M
D
EMWLSKTERT
fig|749531.3.peg.4536
Escherichia coli MS 69-1
MV
V
RS
L
IDQ
GV
KQ
V
F
G
YP
G
GA
V
LD
I
Y
D
A
L
HTV
-
G
G
I
D
H
V
LV
RHEQ
A
A
VHM
A
D
G
L
A
RAT
G
E
V
GV
--
V
LVT
SGPG
A
TN
A
ITG
I
A
T
A
YM
D
SI
PL
V
V
L
SG
QVATSL
IG
--
Y
D
A
FQE
C
D
MV
--------
GISRPVV
K
HSF
LV
KQT
ED
I
P
QV
L
KK
A
FWL
A
A
S
-
GRPG
P
V
V
VDLP
K
D
I
LNPANKLP
YVW
PESVSMRSYNPT-
-
-TSGHKGQ
I
KR
A
LQT
L
AA
A
KK
P
V
V
YV
G
G
G
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
VVSS
L
M
GLG
AF
P
AT
H
R
QAL
GM
L
GM
H
G
TYEANMT
M
H
NAD
V
I
FA
VG
V
RF
DD
R
TTNNLAK
Y
C
P
-
NA
TV
L
HIDIDP
T
S
I
SKTVTAD
I
P
IVGD
ARQV
L
EQ
M
L
EL
L
SQESVHQ
PL
D
EI
RD
W
W
Q
QIEQW
R
ARQCLKYD--THS
E
----------------------------
K
-
IKPQAVIET
L
WR
----
LTKGDAYV
T
S
DVG
QH
QM
F
AA
LY
-
YPFDK
PR
RW
I
N
S
G
--------
GL
G
T
MG
F
GLP
A
A
L
G
V
KM
A
L
P
EET
VVC
VT
GDG
SIQ
M
NIQ
E
LS
T
AL
Q
YE
LPV
L
V
V
NL
NN
RY
LG
M
V
K
-
QWQD
M
IYSGRHSQSYMQSL
-----------
PD
F
VR
LA
E
A
Y
G
HV
G
IQ
I
SHPQ
E
LES
K
L
SEALEQ
VRN
NR
L
VF
V
D
V
T
V
D
GS
--------
E
HVY
P
M
Q
IR
G
G
G
M
D
EMWLSKTERT
fig|670897.3.peg.1897
Escherichia coli 2362-75
MV
V
RS
L
IDQ
GV
KQ
V
F
G
YP
G
GA
V
LD
I
Y
D
A
L
HTV
-
G
G
I
D
H
V
LV
RHEQ
A
A
VHM
A
D
G
L
A
RAT
G
E
V
GV
--
V
LVT
SGPG
A
TN
A
ITG
I
A
T
A
YM
D
SI
PL
V
V
L
SG
QVATSL
IG
--
Y
D
A
FQE
C
D
MV
--------
GISRPVV
K
HSF
LV
KQT
ED
I
P
QV
L
KK
A
FWL
A
A
S
-
GRPG
P
V
V
VDLP
K
D
I
LNPANKLP
YVW
PESVSMRSYNPT-
-
-TSGHKGQ
I
KR
A
LQT
L
VA
A
KK
P
V
V
YV
G
G
G
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
VVSS
L
M
GLG
AF
P
AT
H
R
QAL
GM
L
GM
H
G
TYEANMT
M
H
NAD
V
I
FA
VG
V
RF
DD
R
TTNNLAK
Y
C
P
-
NA
TV
L
HIDIDP
T
S
I
SKTVTAD
I
P
IVGD
ARQV
L
EQ
M
L
EL
L
SQESVHQ
PL
D
EI
RD
W
W
Q
QIEQW
R
ARQCLKYD--THS
E
----------------------------
K
-
IKPQAVIET
L
WR
----
LTNGDAYV
T
S
DVG
QH
QM
F
AA
LY
-
YPFDK
PR
RW
I
N
S
G
--------
GL
G
T
MG
F
GLP
A
A
L
G
V
KM
A
L
P
EET
VVC
VT
GDG
SIQ
M
NIQ
E
LS
T
AL
Q
YE
LPV
L
V
V
NL
NN
RY
LG
M
V
K
-
QWQD
M
IYSGRHSQSYMQSL
-----------
PD
F
VR
LA
E
A
Y
G
HV
G
IQ
I
SHPQ
E
LES
K
L
SEALEQ
VRN
NR
L
VF
V
D
V
T
V
D
GS
--------
E
HVY
P
M
Q
IR
G
G
G
M
D
EMWLSKTERT
fig|216593.1.peg.3495
Escherichia coli E2348/69 (39-604/604)
MV
V
RS
L
IDQ
GV
KQ
V
F
G
YP
G
GA
V
LD
I
Y
D
A
L
HTV
-
G
G
I
D
H
V
LV
RHEQ
A
A
VHM
A
D
G
L
A
RAT
G
E
V
GV
--
V
LVT
SGPG
A
TN
A
ITG
I
A
T
A
YM
D
SI
PL
V
V
L
SG
QVATSL
IG
--
Y
D
A
FQE
C
D
MV
--------
GISRPVV
K
HSF
LV
KQT
ED
I
P
QV
L
KK
A
FWL
A
A
S
-
GRPG
P
V
V
VDLP
K
D
I
LNPANKLP
YVW
PESVSMRSYNPT-
-
-TSGHKGQ
I
KR
A
LQT
L
VA
A
KK
P
V
V
YV
G
G
G
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
VVSS
L
M
GLG
AF
P
AT
H
R
QAL
GM
L
GM
H
G
TYEANMT
M
H
NAD
V
I
FA
VG
V
RF
DD
R
TTNNLAK
Y
C
P
-
NA
TV
L
HIDIDP
T
S
I
SKTVTAD
I
P
IVGD
ARQV
L
EQ
M
L
EL
L
SQESVHQ
PL
D
EI
RD
W
W
Q
QIEQW
R
ARQCLKYD--THS
E
----------------------------
K
-
IKPQAVIET
L
WR
----
LTNGDAYV
T
S
DVG
QH
QM
F
AA
LY
-
YPFDK
PR
RW
I
N
S
G
--------
GL
G
T
MG
F
GLP
A
A
L
G
V
KM
A
L
P
EET
VVC
VT
GDG
SIQ
M
NIQ
E
LS
T
AL
Q
YE
LPV
L
V
V
NL
NN
RY
LG
M
V
K
-
QWQD
M
IYSGRHSQSYMQSL
-----------
PD
F
VR
LA
E
A
Y
G
HV
G
IQ
I
SHPQ
E
LES
K
L
SEALEQ
VRN
NR
L
VF
V
D
V
T
V
D
GS
--------
E
HVY
P
M
Q
IR
G
G
G
M
D
EMWLSKTERT
fig|656393.3.peg.693
Escherichia coli H299
MV
V
RS
L
IDQ
GV
KQ
V
F
G
YP
G
GA
V
LD
I
Y
D
A
L
HTV
-
G
G
I
D
H
V
LV
RHEQ
A
A
VHM
A
D
G
L
A
RAT
G
E
V
GV
--
V
LVT
SGPG
A
TN
A
ITG
I
A
T
A
YM
D
SI
PL
V
V
L
SG
QVATSL
IG
--
Y
D
A
FQE
C
D
MV
--------
GISRPVV
K
HSF
LV
KQT
ED
I
P
QV
L
KK
A
FWL
A
A
S
-
GRPG
P
V
V
VDLP
K
D
I
LNPANKLP
YVW
PESVSMRSYNPT-
-
-TSGHKGQ
I
KR
A
LQT
L
VA
A
KK
P
V
V
YV
G
G
G
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
VVSS
L
M
GLG
AF
P
AT
H
R
QAL
GM
L
GM
H
G
TYEANMT
M
H
NAD
V
I
FA
VG
V
RF
DD
R
TTNNLAK
Y
C
P
-
NA
TV
L
HIDIDP
T
S
I
SKTVTAD
I
P
IVGD
ARQV
L
EQ
M
L
EL
L
SQESVHQ
PL
D
EI
RD
W
W
Q
QIEQW
R
ARQCLKYD--THS
E
----------------------------
K
-
IKPQAVIET
L
WR
----
LTNGDAYV
T
S
DVG
QH
QM
F
AA
LY
-
YPFDK
PR
RW
I
N
S
G
--------
GL
G
T
MG
F
GLP
A
A
L
G
V
KM
A
L
P
EET
VVC
VT
GDG
SIQ
M
NIQ
E
LS
T
AL
Q
YE
LPV
L
V
V
NL
NN
RY
LG
M
V
K
-
QWQD
M
IYSGRHSQSYMQSL
-----------
PD
F
VR
LA
E
A
Y
G
HV
G
IQ
I
SHPQ
E
LES
K
L
SEALEQ
VRN
NR
L
VF
V
D
V
T
V
D
GS
--------
E
HVY
P
M
Q
IR
G
G
G
M
D
EMWLSKTERT
fig|574521.7.peg.85
Escherichia coli O127:H6 str. E2348/69 (9-574/574)
MV
V
RS
L
IDQ
GV
KQ
V
F
G
YP
G
GA
V
LD
I
Y
D
A
L
HTV
-
G
G
I
D
H
V
LV
RHEQ
A
A
VHM
A
D
G
L
A
RAT
G
E
V
GV
--
V
LVT
SGPG
A
TN
A
ITG
I
A
T
A
YM
D
SI
PL
V
V
L
SG
QVATSL
IG
--
Y
D
A
FQE
C
D
MV
--------
GISRPVV
K
HSF
LV
KQT
ED
I
P
QV
L
KK
A
FWL
A
A
S
-
GRPG
P
V
V
VDLP
K
D
I
LNPANKLP
YVW
PESVSMRSYNPT-
-
-TSGHKGQ
I
KR
A
LQT
L
VA
A
KK
P
V
V
YV
G
G
G
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
VVSS
L
M
GLG
AF
P
AT
H
R
QAL
GM
L
GM
H
G
TYEANMT
M
H
NAD
V
I
FA
VG
V
RF
DD
R
TTNNLAK
Y
C
P
-
NA
TV
L
HIDIDP
T
S
I
SKTVTAD
I
P
IVGD
ARQV
L
EQ
M
L
EL
L
SQESVHQ
PL
D
EI
RD
W
W
Q
QIEQW
R
ARQCLKYD--THS
E
----------------------------
K
-
IKPQAVIET
L
WR
----
LTNGDAYV
T
S
DVG
QH
QM
F
AA
LY
-
YPFDK
PR
RW
I
N
S
G
--------
GL
G
T
MG
F
GLP
A
A
L
G
V
KM
A
L
P
EET
VVC
VT
GDG
SIQ
M
NIQ
E
LS
T
AL
Q
YE
LPV
L
V
V
NL
NN
RY
LG
M
V
K
-
QWQD
M
IYSGRHSQSYMQSL
-----------
PD
F
VR
LA
E
A
Y
G
HV
G
IQ
I
SHPQ
E
LES
K
L
SEALEQ
VRN
NR
L
VF
V
D
V
T
V
D
GS
--------
E
HVY
P
M
Q
IR
G
G
G
M
D
EMWLSKTERT
fig|439855.10.peg.258
Escherichia coli SMS-3-5
MV
V
RS
L
IDQ
GV
KQ
V
F
G
YP
G
GA
V
LD
I
Y
D
A
L
HTV
-
G
G
I
D
H
V
LV
RHEQ
A
A
VHM
A
D
G
L
A
RAT
G
E
V
GV
--
V
LVT
SGPG
A
TN
A
ITG
I
A
T
A
YM
D
SI
PL
V
V
L
SG
QVATSL
IG
--
Y
D
A
FQE
C
D
MV
--------
GISRPVV
K
HSF
LV
KQT
ED
I
P
QV
L
KK
A
FWL
A
A
S
-
GRPG
P
V
V
VDLP
K
D
I
LNPANKLP
YVW
PESVSMRSYNPT-
-
-TSGHKGQ
I
KR
A
LQT
L
VA
A
KK
P
V
V
YV
G
G
G
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
VVSS
L
M
GLG
AF
P
AT
H
R
QAL
GM
L
GM
H
G
TYEANMT
M
H
NAD
V
I
FA
VG
V
RF
DD
R
TTNNLAK
Y
C
P
-
NA
TV
L
HIDIDP
T
S
I
SKTVTAD
I
P
IVGD
ARQV
L
EQ
M
F
EL
L
SQESVHQ
PL
D
EI
RD
W
W
Q
QIEQW
R
ARQCLKYD--SHS
E
----------------------------
K
-
IKPQAVIET
L
WR
----
LTKGDAYV
T
S
DVG
QH
QM
F
AA
LY
-
YPFDK
PR
RW
I
N
S
G
--------
GL
G
T
MG
F
GLP
A
A
L
G
V
KM
A
L
P
EET
VVC
VT
GDG
SIQ
M
NIQ
E
LS
T
AL
Q
YE
LPV
L
V
V
NL
NN
RY
LG
M
V
K
-
QWQD
M
IYSGRHSQSYMQSL
-----------
PD
F
VR
LA
E
A
Y
G
HV
G
IQ
I
SHPQ
E
LES
K
L
SEALEQ
VRN
NR
L
VF
V
D
V
T
V
D
GS
--------
E
HVY
P
M
Q
IR
G
G
G
M
D
EMWLSKTERT
fig|562.371.peg.4017
Escherichia coli 1044A (9-574/574)
MV
V
RS
L
IDQ
GV
KQ
V
F
G
YP
G
GA
V
LD
I
Y
D
A
L
HTV
-
G
G
I
G
H
V
LV
RHEQ
A
A
VHM
A
D
G
L
A
RAT
G
E
V
GV
--
V
LVT
SGPG
A
TN
A
ITG
I
A
T
A
YM
D
SI
PL
V
V
L
SG
QVATSL
IG
--
Y
D
A
FQE
C
D
MV
--------
GISRPVV
K
HSF
LV
KQT
ED
I
P
QV
L
KK
A
FWL
A
A
S
-
GRPG
P
V
V
VDLP
K
D
I
LNPANKLP
YVW
PESVSMRSYNPT-
-
-TTGHKGQ
I
KR
A
LQT
L
VA
A
KK
P
V
V
YV
G
G
G
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
VVSS
L
M
GLG
AF
P
AT
H
R
QAL
GM
L
GM
H
G
TYEANMT
M
H
NAD
V
I
FA
VG
V
RF
DD
R
TTNNLAK
Y
C
P
-
NA
TV
L
HIDIDP
T
S
I
SKTVTAD
I
P
IVGD
ARQV
L
EQ
M
L
EL
L
SQESAHQ
PL
D
EI
RD
W
W
Q
QIEQW
R
ARQCLKYD--THS
E
----------------------------
K
-
IKPQAVIET
L
WR
----
LTKGGAYV
T
S
DVG
QH
QM
F
AA
LY
-
YPFDK
PR
RW
I
N
S
G
--------
GL
G
T
MG
F
GLP
A
A
L
G
V
KM
A
L
P
EET
VVC
VT
GDG
SIQ
M
NIQ
E
LS
T
AL
Q
YE
LPV
L
V
V
NL
NN
RY
LG
M
V
K
-
QWQD
M
IYSGRHSQSYMQSL
-----------
PD
F
VR
LA
E
A
Y
G
HV
G
IQ
I
SHPQ
E
LES
K
L
SEALEQ
VRN
NR
L
VF
V
D
V
T
V
D
GS
--------
E
HVY
P
M
Q
IR
G
G
G
M
D
EMWLSKTERT
fig|562.373.peg.2188
Escherichia coli 1125A (9-574/574)
MV
V
RS
L
IDQ
GV
KQ
V
F
G
YP
G
GA
V
LD
I
Y
D
A
L
HTV
-
G
G
I
G
H
V
LV
RHEQ
A
A
VHM
A
D
G
L
A
RAT
G
E
V
GV
--
V
LVT
SGPG
A
TN
A
ITG
I
A
T
A
YM
D
SI
PL
V
V
L
SG
QVATSL
IG
--
Y
D
A
FQE
C
D
MV
--------
GISRPVV
K
HSF
LV
KQT
ED
I
P
QV
L
KK
A
FWL
A
A
S
-
GRPG
P
V
V
VDLP
K
D
I
LNPANKLP
YVW
PESVSMRSYNPT-
-
-TTGHKGQ
I
KR
A
LQT
L
VA
A
KK
P
V
V
YV
G
G
G
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
VVSS
L
M
GLG
AF
P
AT
H
R
QAL
GM
L
GM
H
G
TYEANMT
M
H
NAD
V
I
FA
VG
V
RF
DD
R
TTNNLAK
Y
C
P
-
NA
TV
L
HIDIDP
T
S
I
SKTVTAD
I
P
IVGD
ARQV
L
EQ
M
L
EL
L
SQESAHQ
PL
D
EI
RD
W
W
Q
QIEQW
R
ARQCLKYD--THS
E
----------------------------
K
-
IKPQAVIET
L
WR
----
LTKGGAYV
T
S
DVG
QH
QM
F
AA
LY
-
YPFDK
PR
RW
I
N
S
G
--------
GL
G
T
MG
F
GLP
A
A
L
G
V
KM
A
L
P
EET
VVC
VT
GDG
SIQ
M
NIQ
E
LS
T
AL
Q
YE
LPV
L
V
V
NL
NN
RY
LG
M
V
K
-
QWQD
M
IYSGRHSQSYMQSL
-----------
PD
F
VR
LA
E
A
Y
G
HV
G
IQ
I
SHPQ
E
LES
K
L
SEALEQ
VRN
NR
L
VF
V
D
V
T
V
D
GS
--------
E
HVY
P
M
Q
IR
G
G
G
M
D
EMWLSKTERT
fig|562.372.peg.3039
Escherichia coli 1212A (9-574/574)
MV
V
RS
L
IDQ
GV
KQ
V
F
G
YP
G
GA
V
LD
I
Y
D
A
L
HTV
-
G
G
I
G
H
V
LV
RHEQ
A
A
VHM
A
D
G
L
A
RAT
G
E
V
GV
--
V
LVT
SGPG
A
TN
A
ITG
I
A
T
A
YM
D
SI
PL
V
V
L
SG
QVATSL
IG
--
Y
D
A
FQE
C
D
MV
--------
GISRPVV
K
HSF
LV
KQT
ED
I
P
QV
L
KK
A
FWL
A
A
S
-
GRPG
P
V
V
VDLP
K
D
I
LNPANKLP
YVW
PESVSMRSYNPT-
-
-TTGHKGQ
I
KR
A
LQT
L
VA
A
KK
P
V
V
YV
G
G
G
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
VVSS
L
M
GLG
AF
P
AT
H
R
QAL
GM
L
GM
H
G
TYEANMT
M
H
NAD
V
I
FA
VG
V
RF
DD
R
TTNNLAK
Y
C
P
-
NA
TV
L
HIDIDP
T
S
I
SKTVTAD
I
P
IVGD
ARQV
L
EQ
M
L
EL
L
SQESAHQ
PL
D
EI
RD
W
W
Q
QIEQW
R
ARQCLKYD--THS
E
----------------------------
K
-
IKPQAVIET
L
WR
----
LTKGGAYV
T
S
DVG
QH
QM
F
AA
LY
-
YPFDK
PR
RW
I
N
S
G
--------
GL
G
T
MG
F
GLP
A
A
L
G
V
KM
A
L
P
EET
VVC
VT
GDG
SIQ
M
NIQ
E
LS
T
AL
Q
YE
LPV
L
V
V
NL
NN
RY
LG
M
V
K
-
QWQD
M
IYSGRHSQSYMQSL
-----------
PD
F
VR
LA
E
A
Y
G
HV
G
IQ
I
SHPQ
E
LES
K
L
SEALEQ
VRN
NR
L
VF
V
D
V
T
V
D
GS
--------
E
HVY
P
M
Q
IR
G
G
G
M
D
EMWLSKTERT
fig|562.374.peg.2230
Escherichia coli 536A (9-574/574)
MV
V
RS
L
IDQ
GV
KQ
V
F
G
YP
G
GA
V
LD
I
Y
D
A
L
HTV
-
G
G
I
G
H
V
LV
RHEQ
A
A
VHM
A
D
G
L
A
RAT
G
E
V
GV
--
V
LVT
SGPG
A
TN
A
ITG
I
A
T
A
YM
D
SI
PL
V
V
L
SG
QVATSL
IG
--
Y
D
A
FQE
C
D
MV
--------
GISRPVV
K
HSF
LV
KQT
ED
I
P
QV
L
KK
A
FWL
A
A
S
-
GRPG
P
V
V
VDLP
K
D
I
LNPANKLP
YVW
PESVSMRSYNPT-
-
-TTGHKGQ
I
KR
A
LQT
L
VA
A
KK
P
V
V
YV
G
G
G
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
VVSS
L
M
GLG
AF
P
AT
H
R
QAL
GM
L
GM
H
G
TYEANMT
M
H
NAD
V
I
FA
VG
V
RF
DD
R
TTNNLAK
Y
C
P
-
NA
TV
L
HIDIDP
T
S
I
SKTVTAD
I
P
IVGD
ARQV
L
EQ
M
L
EL
L
SQESAHQ
PL
D
EI
RD
W
W
Q
QIEQW
R
ARQCLKYD--THS
E
----------------------------
K
-
IKPQAVIET
L
WR
----
LTKGGAYV
T
S
DVG
QH
QM
F
AA
LY
-
YPFDK
PR
RW
I
N
S
G
--------
GL
G
T
MG
F
GLP
A
A
L
G
V
KM
A
L
P
EET
VVC
VT
GDG
SIQ
M
NIQ
E
LS
T
AL
Q
YE
LPV
L
V
V
NL
NN
RY
LG
M
V
K
-
QWQD
M
IYSGRHSQSYMQSL
-----------
PD
F
VR
LA
E
A
Y
G
HV
G
IQ
I
SHPQ
E
LES
K
L
SEALEQ
VRN
NR
L
VF
V
D
V
T
V
D
GS
--------
E
HVY
P
M
Q
IR
G
G
G
M
D
EMWLSKTERT
fig|83334.1.peg.169
Escherichia coli O157:H7 (9-574/574)
MV
V
RS
L
IDQ
GV
KQ
V
F
G
YP
G
GA
V
LD
I
Y
D
A
L
HTV
-
G
G
I
G
H
V
LV
RHEQ
A
A
VHM
A
D
G
L
A
RAT
G
E
V
GV
--
V
LVT
SGPG
A
TN
A
ITG
I
A
T
A
YM
D
SI
PL
V
V
L
SG
QVATSL
IG
--
Y
D
A
FQE
C
D
MV
--------
GISRPVV
K
HSF
LV
KQT
ED
I
P
QV
L
KK
A
FWL
A
A
S
-
GRPG
P
V
V
VDLP
K
D
I
LNPANKLP
YVW
PESVSMRSYNPT-
-
-TTGHKGQ
I
KR
A
LQT
L
VA
A
KK
P
V
V
YV
G
G
G
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
VVSS
L
M
GLG
AF
P
AT
H
R
QAL
GM
L
GM
H
G
TYEANMT
M
H
NAD
V
I
FA
VG
V
RF
DD
R
TTNNLAK
Y
C
P
-
NA
TV
L
HIDIDP
T
S
I
SKTVTAD
I
P
IVGD
ARQV
L
EQ
M
L
EL
L
SQESAHQ
PL
D
EI
RD
W
W
Q
QIEQW
R
ARQCLKYD--THS
E
----------------------------
K
-
IKPQAVIET
L
WR
----
LTKGGAYV
T
S
DVG
QH
QM
F
AA
LY
-
YPFDK
PR
RW
I
N
S
G
--------
GL
G
T
MG
F
GLP
A
A
L
G
V
KM
A
L
P
EET
VVC
VT
GDG
SIQ
M
NIQ
E
LS
T
AL
Q
YE
LPV
L
V
V
NL
NN
RY
LG
M
V
K
-
QWQD
M
IYSGRHSQSYMQSL
-----------
PD
F
VR
LA
E
A
Y
G
HV
G
IQ
I
SHPQ
E
LES
K
L
SEALEQ
VRN
NR
L
VF
V
D
V
T
V
D
GS
--------
E
HVY
P
M
Q
IR
G
G
G
M
D
EMWLSKTERT
fig|155864.1.peg.81
Escherichia coli O157:H7 EDL933 (37-602/602)
MV
V
RS
L
IDQ
GV
KQ
V
F
G
YP
G
GA
V
LD
I
Y
D
A
L
HTV
-
G
G
I
G
H
V
LV
RHEQ
A
A
VHM
A
D
G
L
A
RAT
G
E
V
GV
--
V
LVT
SGPG
A
TN
A
ITG
I
A
T
A
YM
D
SI
PL
V
V
L
SG
QVATSL
IG
--
Y
D
A
FQE
C
D
MV
--------
GISRPVV
K
HSF
LV
KQT
ED
I
P
QV
L
KK
A
FWL
A
A
S
-
GRPG
P
V
V
VDLP
K
D
I
LNPANKLP
YVW
PESVSMRSYNPT-
-
-TTGHKGQ
I
KR
A
LQT
L
VA
A
KK
P
V
V
YV
G
G
G
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
VVSS
L
M
GLG
AF
P
AT
H
R
QAL
GM
L
GM
H
G
TYEANMT
M
H
NAD
V
I
FA
VG
V
RF
DD
R
TTNNLAK
Y
C
P
-
NA
TV
L
HIDIDP
T
S
I
SKTVTAD
I
P
IVGD
ARQV
L
EQ
M
L
EL
L
SQESAHQ
PL
D
EI
RD
W
W
Q
QIEQW
R
ARQCLKYD--THS
E
----------------------------
K
-
IKPQAVIET
L
WR
----
LTKGGAYV
T
S
DVG
QH
QM
F
AA
LY
-
YPFDK
PR
RW
I
N
S
G
--------
GL
G
T
MG
F
GLP
A
A
L
G
V
KM
A
L
P
EET
VVC
VT
GDG
SIQ
M
NIQ
E
LS
T
AL
Q
YE
LPV
L
V
V
NL
NN
RY
LG
M
V
K
-
QWQD
M
IYSGRHSQSYMQSL
-----------
PD
F
VR
LA
E
A
Y
G
HV
G
IQ
I
SHPQ
E
LES
K
L
SEALEQ
VRN
NR
L
VF
V
D
V
T
V
D
GS
--------
E
HVY
P
M
Q
IR
G
G
G
M
D
EMWLSKTERT
fig|155864.8.peg.82
Escherichia coli O157:H7 EDL933 (9-574/574)
MV
V
RS
L
IDQ
GV
KQ
V
F
G
YP
G
GA
V
LD
I
Y
D
A
L
HTV
-
G
G
I
G
H
V
LV
RHEQ
A
A
VHM
A
D
G
L
A
RAT
G
E
V
GV
--
V
LVT
SGPG
A
TN
A
ITG
I
A
T
A
YM
D
SI
PL
V
V
L
SG
QVATSL
IG
--
Y
D
A
FQE
C
D
MV
--------
GISRPVV
K
HSF
LV
KQT
ED
I
P
QV
L
KK
A
FWL
A
A
S
-
GRPG
P
V
V
VDLP
K
D
I
LNPANKLP
YVW
PESVSMRSYNPT-
-
-TTGHKGQ
I
KR
A
LQT
L
VA
A
KK
P
V
V
YV
G
G
G
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
VVSS
L
M
GLG
AF
P
AT
H
R
QAL
GM
L
GM
H
G
TYEANMT
M
H
NAD
V
I
FA
VG
V
RF
DD
R
TTNNLAK
Y
C
P
-
NA
TV
L
HIDIDP
T
S
I
SKTVTAD
I
P
IVGD
ARQV
L
EQ
M
L
EL
L
SQESAHQ
PL
D
EI
RD
W
W
Q
QIEQW
R
ARQCLKYD--THS
E
----------------------------
K
-
IKPQAVIET
L
WR
----
LTKGGAYV
T
S
DVG
QH
QM
F
AA
LY
-
YPFDK
PR
RW
I
N
S
G
--------
GL
G
T
MG
F
GLP
A
A
L
G
V
KM
A
L
P
EET
VVC
VT
GDG
SIQ
M
NIQ
E
LS
T
AL
Q
YE
LPV
L
V
V
NL
NN
RY
LG
M
V
K
-
QWQD
M
IYSGRHSQSYMQSL
-----------
PD
F
VR
LA
E
A
Y
G
HV
G
IQ
I
SHPQ
E
LES
K
L
SEALEQ
VRN
NR
L
VF
V
D
V
T
V
D
GS
--------
E
HVY
P
M
Q
IR
G
G
G
M
D
EMWLSKTERT
fig|444454.5.peg.4545
Escherichia coli O157:H7 str. EC4024 (9-574/574)
MV
V
RS
L
IDQ
GV
KQ
V
F
G
YP
G
GA
V
LD
I
Y
D
A
L
HTV
-
G
G
I
G
H
V
LV
RHEQ
A
A
VHM
A
D
G
L
A
RAT
G
E
V
GV
--
V
LVT
SGPG
A
TN
A
ITG
I
A
T
A
YM
D
SI
PL
V
V
L
SG
QVATSL
IG
--
Y
D
A
FQE
C
D
MV
--------
GISRPVV
K
HSF
LV
KQT
ED
I
P
QV
L
KK
A
FWL
A
A
S
-
GRPG
P
V
V
VDLP
K
D
I
LNPANKLP
YVW
PESVSMRSYNPT-
-
-TTGHKGQ
I
KR
A
LQT
L
VA
A
KK
P
V
V
YV
G
G
G
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
VVSS
L
M
GLG
AF
P
AT
H
R
QAL
GM
L
GM
H
G
TYEANMT
M
H
NAD
V
I
FA
VG
V
RF
DD
R
TTNNLAK
Y
C
P
-
NA
TV
L
HIDIDP
T
S
I
SKTVTAD
I
P
IVGD
ARQV
L
EQ
M
L
EL
L
SQESAHQ
PL
D
EI
RD
W
W
Q
QIEQW
R
ARQCLKYD--THS
E
----------------------------
K
-
IKPQAVIET
L
WR
----
LTKGGAYV
T
S
DVG
QH
QM
F
AA
LY
-
YPFDK
PR
RW
I
N
S
G
--------
GL
G
T
MG
F
GLP
A
A
L
G
V
KM
A
L
P
EET
VVC
VT
GDG
SIQ
M
NIQ
E
LS
T
AL
Q
YE
LPV
L
V
V
NL
NN
RY
LG
M
V
K
-
QWQD
M
IYSGRHSQSYMQSL
-----------
PD
F
VR
LA
E
A
Y
G
HV
G
IQ
I
SHPQ
E
LES
K
L
SEALEQ
VRN
NR
L
VF
V
D
V
T
V
D
GS
--------
E
HVY
P
M
Q
IR
G
G
G
M
D
EMWLSKTERT
fig|444449.5.peg.3994
Escherichia coli O157:H7 str. EC4042 (9-574/574)
MV
V
RS
L
IDQ
GV
KQ
V
F
G
YP
G
GA
V
LD
I
Y
D
A
L
HTV
-
G
G
I
G
H
V
LV
RHEQ
A
A
VHM
A
D
G
L
A
RAT
G
E
V
GV
--
V
LVT
SGPG
A
TN
A
ITG
I
A
T
A
YM
D
SI
PL
V
V
L
SG
QVATSL
IG
--
Y
D
A
FQE
C
D
MV
--------
GISRPVV
K
HSF
LV
KQT
ED
I
P
QV
L
KK
A
FWL
A
A
S
-
GRPG
P
V
V
VDLP
K
D
I
LNPANKLP
YVW
PESVSMRSYNPT-
-
-TTGHKGQ
I
KR
A
LQT
L
VA
A
KK
P
V
V
YV
G
G
G
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
VVSS
L
M
GLG
AF
P
AT
H
R
QAL
GM
L
GM
H
G
TYEANMT
M
H
NAD
V
I
FA
VG
V
RF
DD
R
TTNNLAK
Y
C
P
-
NA
TV
L
HIDIDP
T
S
I
SKTVTAD
I
P
IVGD
ARQV
L
EQ
M
L
EL
L
SQESAHQ
PL
D
EI
RD
W
W
Q
QIEQW
R
ARQCLKYD--THS
E
----------------------------
K
-
IKPQAVIET
L
WR
----
LTKGGAYV
T
S
DVG
QH
QM
F
AA
LY
-
YPFDK
PR
RW
I
N
S
G
--------
GL
G
T
MG
F
GLP
A
A
L
G
V
KM
A
L
P
EET
VVC
VT
GDG
SIQ
M
NIQ
E
LS
T
AL
Q
YE
LPV
L
V
V
NL
NN
RY
LG
M
V
K
-
QWQD
M
IYSGRHSQSYMQSL
-----------
PD
F
VR
LA
E
A
Y
G
HV
G
IQ
I
SHPQ
E
LES
K
L
SEALEQ
VRN
NR
L
VF
V
D
V
T
V
D
GS
--------
E
HVY
P
M
Q
IR
G
G
G
M
D
EMWLSKTERT
fig|444448.5.peg.2753
Escherichia coli O157:H7 str. EC4045 (9-574/574)
MV
V
RS
L
IDQ
GV
KQ
V
F
G
YP
G
GA
V
LD
I
Y
D
A
L
HTV
-
G
G
I
G
H
V
LV
RHEQ
A
A
VHM
A
D
G
L
A
RAT
G
E
V
GV
--
V
LVT
SGPG
A
TN
A
ITG
I
A
T
A
YM
D
SI
PL
V
V
L
SG
QVATSL
IG
--
Y
D
A
FQE
C
D
MV
--------
GISRPVV
K
HSF
LV
KQT
ED
I
P
QV
L
KK
A
FWL
A
A
S
-
GRPG
P
V
V
VDLP
K
D
I
LNPANKLP
YVW
PESVSMRSYNPT-
-
-TTGHKGQ
I
KR
A
LQT
L
VA
A
KK
P
V
V
YV
G
G
G
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
VVSS
L
M
GLG
AF
P
AT
H
R
QAL
GM
L
GM
H
G
TYEANMT
M
H
NAD
V
I
FA
VG
V
RF
DD
R
TTNNLAK
Y
C
P
-
NA
TV
L
HIDIDP
T
S
I
SKTVTAD
I
P
IVGD
ARQV
L
EQ
M
L
EL
L
SQESAHQ
PL
D
EI
RD
W
W
Q
QIEQW
R
ARQCLKYD--THS
E
----------------------------
K
-
IKPQAVIET
L
WR
----
LTKGGAYV
T
S
DVG
QH
QM
F
AA
LY
-
YPFDK
PR
RW
I
N
S
G
--------
GL
G
T
MG
F
GLP
A
A
L
G
V
KM
A
L
P
EET
VVC
VT
GDG
SIQ
M
NIQ
E
LS
T
AL
Q
YE
LPV
L
V
V
NL
NN
RY
LG
M
V
K
-
QWQD
M
IYSGRHSQSYMQSL
-----------
PD
F
VR
LA
E
A
Y
G
HV
G
IQ
I
SHPQ
E
LES
K
L
SEALEQ
VRN
NR
L
VF
V
D
V
T
V
D
GS
--------
E
HVY
P
M
Q
IR
G
G
G
M
D
EMWLSKTERT
fig|444453.5.peg.3356
Escherichia coli O157:H7 str. EC4076 (9-574/574)
MV
V
RS
L
IDQ
GV
KQ
V
F
G
YP
G
GA
V
LD
I
Y
D
A
L
HTV
-
G
G
I
G
H
V
LV
RHEQ
A
A
VHM
A
D
G
L
A
RAT
G
E
V
GV
--
V
LVT
SGPG
A
TN
A
ITG
I
A
T
A
YM
D
SI
PL
V
V
L
SG
QVATSL
IG
--
Y
D
A
FQE
C
D
MV
--------
GISRPVV
K
HSF
LV
KQT
ED
I
P
QV
L
KK
A
FWL
A
A
S
-
GRPG
P
V
V
VDLP
K
D
I
LNPANKLP
YVW
PESVSMRSYNPT-
-
-TTGHKGQ
I
KR
A
LQT
L
VA
A
KK
P
V
V
YV
G
G
G
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
VVSS
L
M
GLG
AF
P
AT
H
R
QAL
GM
L
GM
H
G
TYEANMT
M
H
NAD
V
I
FA
VG
V
RF
DD
R
TTNNLAK
Y
C
P
-
NA
TV
L
HIDIDP
T
S
I
SKTVTAD
I
P
IVGD
ARQV
L
EQ
M
L
EL
L
SQESAHQ
PL
D
EI
RD
W
W
Q
QIEQW
R
ARQCLKYD--THS
E
----------------------------
K
-
IKPQAVIET
L
WR
----
LTKGGAYV
T
S
DVG
QH
QM
F
AA
LY
-
YPFDK
PR
RW
I
N
S
G
--------
GL
G
T
MG
F
GLP
A
A
L
G
V
KM
A
L
P
EET
VVC
VT
GDG
SIQ
M
NIQ
E
LS
T
AL
Q
YE
LPV
L
V
V
NL
NN
RY
LG
M
V
K
-
QWQD
M
IYSGRHSQSYMQSL
-----------
PD
F
VR
LA
E
A
Y
G
HV
G
IQ
I
SHPQ
E
LES
K
L
SEALEQ
VRN
NR
L
VF
V
D
V
T
V
D
GS
--------
E
HVY
P
M
Q
IR
G
G
G
M
D
EMWLSKTERT
fig|444452.5.peg.4320
Escherichia coli O157:H7 str. EC4113 (9-574/574)
MV
V
RS
L
IDQ
GV
KQ
V
F
G
YP
G
GA
V
LD
I
Y
D
A
L
HTV
-
G
G
I
G
H
V
LV
RHEQ
A
A
VHM
A
D
G
L
A
RAT
G
E
V
GV
--
V
LVT
SGPG
A
TN
A
ITG
I
A
T
A
YM
D
SI
PL
V
V
L
SG
QVATSL
IG
--
Y
D
A
FQE
C
D
MV
--------
GISRPVV
K
HSF
LV
KQT
ED
I
P
QV
L
KK
A
FWL
A
A
S
-
GRPG
P
V
V
VDLP
K
D
I
LNPANKLP
YVW
PESVSMRSYNPT-
-
-TTGHKGQ
I
KR
A
LQT
L
VA
A
KK
P
V
V
YV
G
G
G
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
VVSS
L
M
GLG
AF
P
AT
H
R
QAL
GM
L
GM
H
G
TYEANMT
M
H
NAD
V
I
FA
VG
V
RF
DD
R
TTNNLAK
Y
C
P
-
NA
TV
L
HIDIDP
T
S
I
SKTVTAD
I
P
IVGD
ARQV
L
EQ
M
L
EL
L
SQESAHQ
PL
D
EI
RD
W
W
Q
QIEQW
R
ARQCLKYD--THS
E
----------------------------
K
-
IKPQAVIET
L
WR
----
LTKGGAYV
T
S
DVG
QH
QM
F
AA
LY
-
YPFDK
PR
RW
I
N
S
G
--------
GL
G
T
MG
F
GLP
A
A
L
G
V
KM
A
L
P
EET
VVC
VT
GDG
SIQ
M
NIQ
E
LS
T
AL
Q
YE
LPV
L
V
V
NL
NN
RY
LG
M
V
K
-
QWQD
M
IYSGRHSQSYMQSL
-----------
PD
F
VR
LA
E
A
Y
G
HV
G
IQ
I
SHPQ
E
LES
K
L
SEALEQ
VRN
NR
L
VF
V
D
V
T
V
D
GS
--------
E
HVY
P
M
Q
IR
G
G
G
M
D
EMWLSKTERT
fig|444450.8.peg.223
Escherichia coli O157:H7 str. EC4115 (9-574/574)
MV
V
RS
L
IDQ
GV
KQ
V
F
G
YP
G
GA
V
LD
I
Y
D
A
L
HTV
-
G
G
I
G
H
V
LV
RHEQ
A
A
VHM
A
D
G
L
A
RAT
G
E
V
GV
--
V
LVT
SGPG
A
TN
A
ITG
I
A
T
A
YM
D
SI
PL
V
V
L
SG
QVATSL
IG
--
Y
D
A
FQE
C
D
MV
--------
GISRPVV
K
HSF
LV
KQT
ED
I
P
QV
L
KK
A
FWL
A
A
S
-
GRPG
P
V
V
VDLP
K
D
I
LNPANKLP
YVW
PESVSMRSYNPT-
-
-TTGHKGQ
I
KR
A
LQT
L
VA
A
KK
P
V
V
YV
G
G
G
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
VVSS
L
M
GLG
AF
P
AT
H
R
QAL
GM
L
GM
H
G
TYEANMT
M
H
NAD
V
I
FA
VG
V
RF
DD
R
TTNNLAK
Y
C
P
-
NA
TV
L
HIDIDP
T
S
I
SKTVTAD
I
P
IVGD
ARQV
L
EQ
M
L
EL
L
SQESAHQ
PL
D
EI
RD
W
W
Q
QIEQW
R
ARQCLKYD--THS
E
----------------------------
K
-
IKPQAVIET
L
WR
----
LTKGGAYV
T
S
DVG
QH
QM
F
AA
LY
-
YPFDK
PR
RW
I
N
S
G
--------
GL
G
T
MG
F
GLP
A
A
L
G
V
KM
A
L
P
EET
VVC
VT
GDG
SIQ
M
NIQ
E
LS
T
AL
Q
YE
LPV
L
V
V
NL
NN
RY
LG
M
V
K
-
QWQD
M
IYSGRHSQSYMQSL
-----------
PD
F
VR
LA
E
A
Y
G
HV
G
IQ
I
SHPQ
E
LES
K
L
SEALEQ
VRN
NR
L
VF
V
D
V
T
V
D
GS
--------
E
HVY
P
M
Q
IR
G
G
G
M
D
EMWLSKTERT
fig|444451.5.peg.4397
Escherichia coli O157:H7 str. EC4196 (9-574/574)
MV
V
RS
L
IDQ
GV
KQ
V
F
G
YP
G
GA
V
LD
I
Y
D
A
L
HTV
-
G
G
I
G
H
V
LV
RHEQ
A
A
VHM
A
D
G
L
A
RAT
G
E
V
GV
--
V
LVT
SGPG
A
TN
A
ITG
I
A
T
A
YM
D
SI
PL
V
V
L
SG
QVATSL
IG
--
Y
D
A
FQE
C
D
MV
--------
GISRPVV
K
HSF
LV
KQT
ED
I
P
QV
L
KK
A
FWL
A
A
S
-
GRPG
P
V
V
VDLP
K
D
I
LNPANKLP
YVW
PESVSMRSYNPT-
-
-TTGHKGQ
I
KR
A
LQT
L
VA
A
KK
P
V
V
YV
G
G
G
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
VVSS
L
M
GLG
AF
P
AT
H
R
QAL
GM
L
GM
H
G
TYEANMT
M
H
NAD
V
I
FA
VG
V
RF
DD
R
TTNNLAK
Y
C
P
-
NA
TV
L
HIDIDP
T
S
I
SKTVTAD
I
P
IVGD
ARQV
L
EQ
M
L
EL
L
SQESAHQ
PL
D
EI
RD
W
W
Q
QIEQW
R
ARQCLKYD--THS
E
----------------------------
K
-
IKPQAVIET
L
WR
----
LTKGGAYV
T
S
DVG
QH
QM
F
AA
LY
-
YPFDK
PR
RW
I
N
S
G
--------
GL
G
T
MG
F
GLP
A
A
L
G
V
KM
A
L
P
EET
VVC
VT
GDG
SIQ
M
NIQ
E
LS
T
AL
Q
YE
LPV
L
V
V
NL
NN
RY
LG
M
V
K
-
QWQD
M
IYSGRHSQSYMQSL
-----------
PD
F
VR
LA
E
A
Y
G
HV
G
IQ
I
SHPQ
E
LES
K
L
SEALEQ
VRN
NR
L
VF
V
D
V
T
V
D
GS
--------
E
HVY
P
M
Q
IR
G
G
G
M
D
EMWLSKTERT
fig|444447.5.peg.2921
Escherichia coli O157:H7 str. EC4206 (9-574/574)
MV
V
RS
L
IDQ
GV
KQ
V
F
G
YP
G
GA
V
LD
I
Y
D
A
L
HTV
-
G
G
I
G
H
V
LV
RHEQ
A
A
VHM
A
D
G
L
A
RAT
G
E
V
GV
--
V
LVT
SGPG
A
TN
A
ITG
I
A
T
A
YM
D
SI
PL
V
V
L
SG
QVATSL
IG
--
Y
D
A
FQE
C
D
MV
--------
GISRPVV
K
HSF
LV
KQT
ED
I
P
QV
L
KK
A
FWL
A
A
S
-
GRPG
P
V
V
VDLP
K
D
I
LNPANKLP
YVW
PESVSMRSYNPT-
-
-TTGHKGQ
I
KR
A
LQT
L
VA
A
KK
P
V
V
YV
G
G
G
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
VVSS
L
M
GLG
AF
P
AT
H
R
QAL
GM
L
GM
H
G
TYEANMT
M
H
NAD
V
I
FA
VG
V
RF
DD
R
TTNNLAK
Y
C
P
-
NA
TV
L
HIDIDP
T
S
I
SKTVTAD
I
P
IVGD
ARQV
L
EQ
M
L
EL
L
SQESAHQ
PL
D
EI
RD
W
W
Q
QIEQW
R
ARQCLKYD--THS
E
----------------------------
K
-
IKPQAVIET
L
WR
----
LTKGGAYV
T
S
DVG
QH
QM
F
AA
LY
-
YPFDK
PR
RW
I
N
S
G
--------
GL
G
T
MG
F
GLP
A
A
L
G
V
KM
A
L
P
EET
VVC
VT
GDG
SIQ
M
NIQ
E
LS
T
AL
Q
YE
LPV
L
V
V
NL
NN
RY
LG
M
V
K
-
QWQD
M
IYSGRHSQSYMQSL
-----------
PD
F
VR
LA
E
A
Y
G
HV
G
IQ
I
SHPQ
E
LES
K
L
SEALEQ
VRN
NR
L
VF
V
D
V
T
V
D
GS
--------
E
HVY
P
M
Q
IR
G
G
G
M
D
EMWLSKTERT
fig|478004.5.peg.2453
Escherichia coli O157:H7 str. EC4401 (9-574/574)
MV
V
RS
L
IDQ
GV
KQ
V
F
G
YP
G
GA
V
LD
I
Y
D
A
L
HTV
-
G
G
I
G
H
V
LV
RHEQ
A
A
VHM
A
D
G
L
A
RAT
G
E
V
GV
--
V
LVT
SGPG
A
TN
A
ITG
I
A
T
A
YM
D
SI
PL
V
V
L
SG
QVATSL
IG
--
Y
D
A
FQE
C
D
MV
--------
GISRPVV
K
HSF
LV
KQT
ED
I
P
QV
L
KK
A
FWL
A
A
S
-
GRPG
P
V
V
VDLP
K
D
I
LNPANKLP
YVW
PESVSMRSYNPT-
-
-TTGHKGQ
I
KR
A
LQT
L
VA
A
KK
P
V
V
YV
G
G
G
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
VVSS
L
M
GLG
AF
P
AT
H
R
QAL
GM
L
GM
H
G
TYEANMT
M
H
NAD
V
I
FA
VG
V
RF
DD
R
TTNNLAK
Y
C
P
-
NA
TV
L
HIDIDP
T
S
I
SKTVTAD
I
P
IVGD
ARQV
L
EQ
M
L
EL
L
SQESAHQ
PL
D
EI
RD
W
W
Q
QIEQW
R
ARQCLKYD--THS
E
----------------------------
K
-
IKPQAVIET
L
WR
----
LTKGGAYV
T
S
DVG
QH
QM
F
AA
LY
-
YPFDK
PR
RW
I
N
S
G
--------
GL
G
T
MG
F
GLP
A
A
L
G
V
KM
A
L
P
EET
VVC
VT
GDG
SIQ
M
NIQ
E
LS
T
AL
Q
YE
LPV
L
V
V
NL
NN
RY
LG
M
V
K
-
QWQD
M
IYSGRHSQSYMQSL
-----------
PD
F
VR
LA
E
A
Y
G
HV
G
IQ
I
SHPQ
E
LES
K
L
SEALEQ
VRN
NR
L
VF
V
D
V
T
V
D
GS
--------
E
HVY
P
M
Q
IR
G
G
G
M
D
EMWLSKTERT
fig|478005.5.peg.4949
Escherichia coli O157:H7 str. EC4486 (37-602/602)
MV
V
RS
L
IDQ
GV
KQ
V
F
G
YP
G
GA
V
LD
I
Y
D
A
L
HTV
-
G
G
I
G
H
V
LV
RHEQ
A
A
VHM
A
D
G
L
A
RAT
G
E
V
GV
--
V
LVT
SGPG
A
TN
A
ITG
I
A
T
A
YM
D
SI
PL
V
V
L
SG
QVATSL
IG
--
Y
D
A
FQE
C
D
MV
--------
GISRPVV
K
HSF
LV
KQT
ED
I
P
QV
L
KK
A
FWL
A
A
S
-
GRPG
P
V
V
VDLP
K
D
I
LNPANKLP
YVW
PESVSMRSYNPT-
-
-TTGHKGQ
I
KR
A
LQT
L
VA
A
KK
P
V
V
YV
G
G
G
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
VVSS
L
M
GLG
AF
P
AT
H
R
QAL
GM
L
GM
H
G
TYEANMT
M
H
NAD
V
I
FA
VG
V
RF
DD
R
TTNNLAK
Y
C
P
-
NA
TV
L
HIDIDP
T
S
I
SKTVTAD
I
P
IVGD
ARQV
L
EQ
M
L
EL
L
SQESAHQ
PL
D
EI
RD
W
W
Q
QIEQW
R
ARQCLKYD--THS
E
----------------------------
K
-
IKPQAVIET
L
WR
----
LTKGGAYV
T
S
DVG
QH
QM
F
AA
LY
-
YPFDK
PR
RW
I
N
S
G
--------
GL
G
T
MG
F
GLP
A
A
L
G
V
KM
A
L
P
EET
VVC
VT
GDG
SIQ
M
NIQ
E
LS
T
AL
Q
YE
LPV
L
V
V
NL
NN
RY
LG
M
V
K
-
QWQD
M
IYSGRHSQSYMQSL
-----------
PD
F
VR
LA
E
A
Y
G
HV
G
IQ
I
SHPQ
E
LES
K
L
SEALEQ
VRN
NR
L
VF
V
D
V
T
V
D
GS
--------
E
HVY
P
M
Q
IR
G
G
G
M
D
EMWLSKTERT
fig|478006.5.peg.4389
Escherichia coli O157:H7 str. EC4501 (9-574/574)
MV
V
RS
L
IDQ
GV
KQ
V
F
G
YP
G
GA
V
LD
I
Y
D
A
L
HTV
-
G
G
I
G
H
V
LV
RHEQ
A
A
VHM
A
D
G
L
A
RAT
G
E
V
GV
--
V
LVT
SGPG
A
TN
A
ITG
I
A
T
A
YM
D
SI
PL
V
V
L
SG
QVATSL
IG
--
Y
D
A
FQE
C
D
MV
--------
GISRPVV
K
HSF
LV
KQT
ED
I
P
QV
L
KK
A
FWL
A
A
S
-
GRPG
P
V
V
VDLP
K
D
I
LNPANKLP
YVW
PESVSMRSYNPT-
-
-TTGHKGQ
I
KR
A
LQT
L
VA
A
KK
P
V
V
YV
G
G
G
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
VVSS
L
M
GLG
AF
P
AT
H
R
QAL
GM
L
GM
H
G
TYEANMT
M
H
NAD
V
I
FA
VG
V
RF
DD
R
TTNNLAK
Y
C
P
-
NA
TV
L
HIDIDP
T
S
I
SKTVTAD
I
P
IVGD
ARQV
L
EQ
M
L
EL
L
SQESAHQ
PL
D
EI
RD
W
W
Q
QIEQW
R
ARQCLKYD--THS
E
----------------------------
K
-
IKPQAVIET
L
WR
----
LTKGGAYV
T
S
DVG
QH
QM
F
AA
LY
-
YPFDK
PR
RW
I
N
S
G
--------
GL
G
T
MG
F
GLP
A
A
L
G
V
KM
A
L
P
EET
VVC
VT
GDG
SIQ
M
NIQ
E
LS
T
AL
Q
YE
LPV
L
V
V
NL
NN
RY
LG
M
V
K
-
QWQD
M
IYSGRHSQSYMQSL
-----------
PD
F
VR
LA
E
A
Y
G
HV
G
IQ
I
SHPQ
E
LES
K
L
SEALEQ
VRN
NR
L
VF
V
D
V
T
V
D
GS
--------
E
HVY
P
M
Q
IR
G
G
G
M
D
EMWLSKTERT
fig|478007.5.peg.4111
Escherichia coli O157:H7 str. EC508 (9-574/574)
MV
V
RS
L
IDQ
GV
KQ
V
F
G
YP
G
GA
V
LD
I
Y
D
A
L
HTV
-
G
G
I
G
H
V
LV
RHEQ
A
A
VHM
A
D
G
L
A
RAT
G
E
V
GV
--
V
LVT
SGPG
A
TN
A
ITG
I
A
T
A
YM
D
SI
PL
V
V
L
SG
QVATSL
IG
--
Y
D
A
FQE
C
D
MV
--------
GISRPVV
K
HSF
LV
KQT
ED
I
P
QV
L
KK
A
FWL
A
A
S
-
GRPG
P
V
V
VDLP
K
D
I
LNPANKLP
YVW
PESVSMRSYNPT-
-
-TTGHKGQ
I
KR
A
LQT
L
VA
A
KK
P
V
V
YV
G
G
G
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
VVSS
L
M
GLG
AF
P
AT
H
R
QAL
GM
L
GM
H
G
TYEANMT
M
H
NAD
V
I
FA
VG
V
RF
DD
R
TTNNLAK
Y
C
P
-
NA
TV
L
HIDIDP
T
S
I
SKTVTAD
I
P
IVGD
ARQV
L
EQ
M
L
EL
L
SQESAHQ
PL
D
EI
RD
W
W
Q
QIEQW
R
ARQCLKYD--THS
E
----------------------------
K
-
IKPQAVIET
L
WR
----
LTKGGAYV
T
S
DVG
QH
QM
F
AA
LY
-
YPFDK
PR
RW
I
N
S
G
--------
GL
G
T
MG
F
GLP
A
A
L
G
V
KM
A
L
P
EET
VVC
VT
GDG
SIQ
M
NIQ
E
LS
T
AL
Q
YE
LPV
L
V
V
NL
NN
RY
LG
M
V
K
-
QWQD
M
IYSGRHSQSYMQSL
-----------
PD
F
VR
LA
E
A
Y
G
HV
G
IQ
I
SHPQ
E
LES
K
L
SEALEQ
VRN
NR
L
VF
V
D
V
T
V
D
GS
--------
E
HVY
P
M
Q
IR
G
G
G
M
D
EMWLSKTERT
fig|478008.5.peg.4668
Escherichia coli O157:H7 str. EC869 (9-574/574)
MV
V
RS
L
IDQ
GV
KQ
V
F
G
YP
G
GA
V
LD
I
Y
D
A
L
HTV
-
G
G
I
G
H
V
LV
RHEQ
A
A
VHM
A
D
G
L
A
RAT
G
E
V
GV
--
V
LVT
SGPG
A
TN
A
ITG
I
A
T
A
YM
D
SI
PL
V
V
L
SG
QVATSL
IG
--
Y
D
A
FQE
C
D
MV
--------
GISRPVV
K
HSF
LV
KQT
ED
I
P
QV
L
KK
A
FWL
A
A
S
-
GRPG
P
V
V
VDLP
K
D
I
LNPANKLP
YVW
PESVSMRSYNPT-
-
-TTGHKGQ
I
KR
A
LQT
L
VA
A
KK
P
V
V
YV
G
G
G
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
VVSS
L
M
GLG
AF
P
AT
H
R
QAL
GM
L
GM
H
G
TYEANMT
M
H
NAD
V
I
FA
VG
V
RF
DD
R
TTNNLAK
Y
C
P
-
NA
TV
L
HIDIDP
T
S
I
SKTVTAD
I
P
IVGD
ARQV
L
EQ
M
L
EL
L
SQESAHQ
PL
D
EI
RD
W
W
Q
QIEQW
R
ARQCLKYD--THS
E
----------------------------
K
-
IKPQAVIET
L
WR
----
LTKGGAYV
T
S
DVG
QH
QM
F
AA
LY
-
YPFDK
PR
RW
I
N
S
G
--------
GL
G
T
MG
F
GLP
A
A
L
G
V
KM
A
L
P
EET
VVC
VT
GDG
SIQ
M
NIQ
E
LS
T
AL
Q
YE
LPV
L
V
V
NL
NN
RY
LG
M
V
K
-
QWQD
M
IYSGRHSQSYMQSL
-----------
PD
F
VR
LA
E
A
Y
G
HV
G
IQ
I
SHPQ
E
LES
K
L
SEALEQ
VRN
NR
L
VF
V
D
V
T
V
D
GS
--------
E
HVY
P
M
Q
IR
G
G
G
M
D
EMWLSKTERT
fig|637388.3.peg.3920
Escherichia coli O157:H7 str. FRIK2000 (9-574/574)
MV
V
RS
L
IDQ
GV
KQ
V
F
G
YP
G
GA
V
LD
I
Y
D
A
L
HTV
-
G
G
I
G
H
V
LV
RHEQ
A
A
VHM
A
D
G
L
A
RAT
G
E
V
GV
--
V
LVT
SGPG
A
TN
A
ITG
I
A
T
A
YM
D
SI
PL
V
V
L
SG
QVATSL
IG
--
Y
D
A
FQE
C
D
MV
--------
GISRPVV
K
HSF
LV
KQT
ED
I
P
QV
L
KK
A
FWL
A
A
S
-
GRPG
P
V
V
VDLP
K
D
I
LNPANKLP
YVW
PESVSMRSYNPT-
-
-TTGHKGQ
I
KR
A
LQT
L
VA
A
KK
P
V
V
YV
G
G
G
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
VVSS
L
M
GLG
AF
P
AT
H
R
QAL
GM
L
GM
H
G
TYEANMT
M
H
NAD
V
I
FA
VG
V
RF
DD
R
TTNNLAK
Y
C
P
-
NA
TV
L
HIDIDP
T
S
I
SKTVTAD
I
P
IVGD
ARQV
L
EQ
M
L
EL
L
SQESAHQ
PL
D
EI
RD
W
W
Q
QIEQW
R
ARQCLKYD--THS
E
----------------------------
K
-
IKPQAVIET
L
WR
----
LTKGGAYV
T
S
DVG
QH
QM
F
AA
LY
-
YPFDK
PR
RW
I
N
S
G
--------
GL
G
T
MG
F
GLP
A
A
L
G
V
KM
A
L
P
EET
VVC
VT
GDG
SIQ
M
NIQ
E
LS
T
AL
Q
YE
LPV
L
V
V
NL
NN
RY
LG
M
V
K
-
QWQD
M
IYSGRHSQSYMQSL
-----------
PD
F
VR
LA
E
A
Y
G
HV
G
IQ
I
SHPQ
E
LES
K
L
SEALEQ
VRN
NR
L
VF
V
D
V
T
V
D
GS
--------
E
HVY
P
M
Q
IR
G
G
G
M
D
EMWLSKTERT
fig|570506.3.peg.1084
Escherichia coli O157:H7 str. FRIK966 (9-574/574)
MV
V
RS
L
IDQ
GV
KQ
V
F
G
YP
G
GA
V
LD
I
Y
D
A
L
HTV
-
G
G
I
G
H
V
LV
RHEQ
A
A
VHM
A
D
G
L
A
RAT
G
E
V
GV
--
V
LVT
SGPG
A
TN
A
ITG
I
A
T
A
YM
D
SI
PL
V
V
L
SG
QVATSL
IG
--
Y
D
A
FQE
C
D
MV
--------
GISRPVV
K
HSF
LV
KQT
ED
I
P
QV
L
KK
A
FWL
A
A
S
-
GRPG
P
V
V
VDLP
K
D
I
LNPANKLP
YVW
PESVSMRSYNPT-
-
-TTGHKGQ
I
KR
A
LQT
L
VA
A
KK
P
V
V
YV
G
G
G
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
VVSS
L
M
GLG
AF
P
AT
H
R
QAL
GM
L
GM
H
G
TYEANMT
M
H
NAD
V
I
FA
VG
V
RF
DD
R
TTNNLAK
Y
C
P
-
NA
TV
L
HIDIDP
T
S
I
SKTVTAD
I
P
IVGD
ARQV
L
EQ
M
L
EL
L
SQESAHQ
PL
D
EI
RD
W
W
Q
QIEQW
R
ARQCLKYD--THS
E
----------------------------
K
-
IKPQAVIET
L
WR
----
LTKGGAYV
T
S
DVG
QH
QM
F
AA
LY
-
YPFDK
PR
RW
I
N
S
G
--------
GL
G
T
MG
F
GLP
A
A
L
G
V
KM
A
L
P
EET
VVC
VT
GDG
SIQ
M
NIQ
E
LS
T
AL
Q
YE
LPV
L
V
V
NL
NN
RY
LG
M
V
K
-
QWQD
M
IYSGRHSQSYMQSL
-----------
PD
F
VR
LA
E
A
Y
G
HV
G
IQ
I
SHPQ
E
LES
K
L
SEALEQ
VRN
NR
L
VF
V
D
V
T
V
D
GS
--------
E
HVY
P
M
Q
IR
G
G
G
M
D
EMWLSKTERT
fig|386585.9.peg.181
Escherichia coli O157:H7 str. Sakai (9-574/574)
MV
V
RS
L
IDQ
GV
KQ
V
F
G
YP
G
GA
V
LD
I
Y
D
A
L
HTV
-
G
G
I
G
H
V
LV
RHEQ
A
A
VHM
A
D
G
L
A
RAT
G
E
V
GV
--
V
LVT
SGPG
A
TN
A
ITG
I
A
T
A
YM
D
SI
PL
V
V
L
SG
QVATSL
IG
--
Y
D
A
FQE
C
D
MV
--------
GISRPVV
K
HSF
LV
KQT
ED
I
P
QV
L
KK
A
FWL
A
A
S
-
GRPG
P
V
V
VDLP
K
D
I
LNPANKLP
YVW
PESVSMRSYNPT-
-
-TTGHKGQ
I
KR
A
LQT
L
VA
A
KK
P
V
V
YV
G
G
G
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
VVSS
L
M
GLG
AF
P
AT
H
R
QAL
GM
L
GM
H
G
TYEANMT
M
H
NAD
V
I
FA
VG
V
RF
DD
R
TTNNLAK
Y
C
P
-
NA
TV
L
HIDIDP
T
S
I
SKTVTAD
I
P
IVGD
ARQV
L
EQ
M
L
EL
L
SQESAHQ
PL
D
EI
RD
W
W
Q
QIEQW
R
ARQCLKYD--THS
E
----------------------------
K
-
IKPQAVIET
L
WR
----
LTKGGAYV
T
S
DVG
QH
QM
F
AA
LY
-
YPFDK
PR
RW
I
N
S
G
--------
GL
G
T
MG
F
GLP
A
A
L
G
V
KM
A
L
P
EET
VVC
VT
GDG
SIQ
M
NIQ
E
LS
T
AL
Q
YE
LPV
L
V
V
NL
NN
RY
LG
M
V
K
-
QWQD
M
IYSGRHSQSYMQSL
-----------
PD
F
VR
LA
E
A
Y
G
HV
G
IQ
I
SHPQ
E
LES
K
L
SEALEQ
VRN
NR
L
VF
V
D
V
T
V
D
GS
--------
E
HVY
P
M
Q
IR
G
G
G
M
D
EMWLSKTERT
fig|544404.4.peg.85
Escherichia coli O157:H7 str. TW14359 (9-574/574)
MV
V
RS
L
IDQ
GV
KQ
V
F
G
YP
G
GA
V
LD
I
Y
D
A
L
HTV
-
G
G
I
G
H
V
LV
RHEQ
A
A
VHM
A
D
G
L
A
RAT
G
E
V
GV
--
V
LVT
SGPG
A
TN
A
ITG
I
A
T
A
YM
D
SI
PL
V
V
L
SG
QVATSL
IG
--
Y
D
A
FQE
C
D
MV
--------
GISRPVV
K
HSF
LV
KQT
ED
I
P
QV
L
KK
A
FWL
A
A
S
-
GRPG
P
V
V
VDLP
K
D
I
LNPANKLP
YVW
PESVSMRSYNPT-
-
-TTGHKGQ
I
KR
A
LQT
L
VA
A
KK
P
V
V
YV
G
G
G
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
VVSS
L
M
GLG
AF
P
AT
H
R
QAL
GM
L
GM
H
G
TYEANMT
M
H
NAD
V
I
FA
VG
V
RF
DD
R
TTNNLAK
Y
C
P
-
NA
TV
L
HIDIDP
T
S
I
SKTVTAD
I
P
IVGD
ARQV
L
EQ
M
L
EL
L
SQESAHQ
PL
D
EI
RD
W
W
Q
QIEQW
R
ARQCLKYD--THS
E
----------------------------
K
-
IKPQAVIET
L
WR
----
LTKGGAYV
T
S
DVG
QH
QM
F
AA
LY
-
YPFDK
PR
RW
I
N
S
G
--------
GL
G
T
MG
F
GLP
A
A
L
G
V
KM
A
L
P
EET
VVC
VT
GDG
SIQ
M
NIQ
E
LS
T
AL
Q
YE
LPV
L
V
V
NL
NN
RY
LG
M
V
K
-
QWQD
M
IYSGRHSQSYMQSL
-----------
PD
F
VR
LA
E
A
Y
G
HV
G
IQ
I
SHPQ
E
LES
K
L
SEALEQ
VRN
NR
L
VF
V
D
V
T
V
D
GS
--------
E
HVY
P
M
Q
IR
G
G
G
M
D
EMWLSKTERT
fig|502346.5.peg.1182
Escherichia coli O157:H7 str. TW14588 (9-574/574)
MV
V
RS
L
IDQ
GV
KQ
V
F
G
YP
G
GA
V
LD
I
Y
D
A
L
HTV
-
G
G
I
G
H
V
LV
RHEQ
A
A
VHM
A
D
G
L
A
RAT
G
E
V
GV
--
V
LVT
SGPG
A
TN
A
ITG
I
A
T
A
YM
D
SI
PL
V
V
L
SG
QVATSL
IG
--
Y
D
A
FQE
C
D
MV
--------
GISRPVV
K
HSF
LV
KQT
ED
I
P
QV
L
KK
A
FWL
A
A
S
-
GRPG
P
V
V
VDLP
K
D
I
LNPANKLP
YVW
PESVSMRSYNPT-
-
-TTGHKGQ
I
KR
A
LQT
L
VA
A
KK
P
V
V
YV
G
G
G
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
VVSS
L
M
GLG
AF
P
AT
H
R
QAL
GM
L
GM
H
G
TYEANMT
M
H
NAD
V
I
FA
VG
V
RF
DD
R
TTNNLAK
Y
C
P
-
NA
TV
L
HIDIDP
T
S
I
SKTVTAD
I
P
IVGD
ARQV
L
EQ
M
L
EL
L
SQESAHQ
PL
D
EI
RD
W
W
Q
QIEQW
R
ARQCLKYD--THS
E
----------------------------
K
-
IKPQAVIET
L
WR
----
LTKGGAYV
T
S
DVG
QH
QM
F
AA
LY
-
YPFDK
PR
RW
I
N
S
G
--------
GL
G
T
MG
F
GLP
A
A
L
G
V
KM
A
L
P
EET
VVC
VT
GDG
SIQ
M
NIQ
E
LS
T
AL
Q
YE
LPV
L
V
V
NL
NN
RY
LG
M
V
K
-
QWQD
M
IYSGRHSQSYMQSL
-----------
PD
F
VR
LA
E
A
Y
G
HV
G
IQ
I
SHPQ
E
LES
K
L
SEALEQ
VRN
NR
L
VF
V
D
V
T
V
D
GS
--------
E
HVY
P
M
Q
IR
G
G
G
M
D
EMWLSKTERT
fig|701177.3.peg.82
Escherichia coli O55:H7 str. CB9615 (9-574/574)
MV
V
RS
L
IDQ
GV
KQ
V
F
G
YP
G
GA
V
LD
I
Y
D
A
L
HTV
-
G
G
I
G
H
V
LV
RHEQ
A
A
VHM
A
D
G
L
A
RAT
G
E
V
GV
--
V
LVT
SGPG
A
TN
A
ITG
I
A
T
A
YM
D
SI
PL
V
V
L
SG
QVATSL
IG
--
Y
D
A
FQE
C
D
MV
--------
GISRPVV
K
HSF
LV
KQT
ED
I
P
QV
L
KK
A
FWL
A
A
S
-
GRPG
P
V
V
VDLP
K
D
I
LNPANKLP
YVW
PESVSMRSYNPT-
-
-TTGHKGQ
I
KR
A
LQT
L
VA
A
KK
P
V
V
YV
G
G
G
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
VVSS
L
M
GLG
AF
P
AT
H
R
QAL
GM
L
GM
H
G
TYEANMT
M
H
NAD
V
I
FA
VG
V
RF
DD
R
TTNNLAK
Y
C
P
-
NA
TV
L
HIDIDP
T
S
I
SKTVTAD
I
P
IVGD
ARQV
L
EQ
M
L
EL
L
SQESAHQ
PL
D
EI
RD
W
W
Q
QIEQW
R
ARQCLKYD--THS
E
----------------------------
K
-
IKPQAVIET
L
WR
----
LTKGGAYV
T
S
DVG
QH
QM
F
AA
LY
-
YPFDK
PR
RW
I
N
S
G
--------
GL
G
T
MG
F
GLP
A
A
L
G
V
KM
A
L
P
EET
VVC
VT
GDG
SIQ
M
NIQ
E
LS
T
AL
Q
YE
LPV
L
V
V
NL
NN
RY
LG
M
V
K
-
QWQD
M
IYSGRHSQSYMQSL
-----------
PD
F
VR
LA
E
A
Y
G
HV
G
IQ
I
SHPQ
E
LES
K
L
SEALEQ
VRN
NR
L
VF
V
D
V
T
V
D
GS
--------
E
HVY
P
M
Q
IR
G
G
G
M
D
EMWLSKTERT
fig|656379.3.peg.319
Escherichia coli FVEC1302 (9-574/574)
MV
V
RS
L
IDQ
GV
KQ
V
F
G
YP
G
GA
V
LD
I
Y
D
A
L
HTV
-
G
G
I
D
H
V
LV
RHEQ
A
A
VHM
A
D
G
L
A
RAT
G
E
V
GV
--
V
LVT
SGPG
A
TN
A
ITG
I
A
T
A
YM
D
SI
PL
V
V
L
SG
QVATSL
IG
--
Y
D
A
FQE
C
D
MV
--------
GISRPVV
K
HSF
LV
KQT
ED
I
P
QV
L
KK
A
FWL
A
A
S
-
GRPG
P
V
V
VDLP
K
D
I
LNPANKLP
Y
I
W
PESVSMRSYNPT-
-
-TSGHKGQ
I
KR
A
LQT
L
VA
A
KK
P
V
V
YV
G
G
G
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
VVSS
L
M
GLG
AF
P
AT
H
R
QAL
GM
L
GM
H
G
TYEANMT
M
H
NAD
V
I
FA
VG
V
RF
DD
R
TTNNLAK
Y
C
P
-
NA
TV
L
HIDIDP
T
S
I
SKTVTAD
I
P
IVGD
ARQV
L
EQ
M
L
EL
L
SQESVHQ
PL
D
EI
RD
W
W
Q
QIEQW
R
ARQCLKYD--SHS
E
----------------------------
K
-
IKPQAVIET
L
WR
----
LTKGDAYV
T
S
DVG
QH
QM
F
AA
LY
-
YPFDK
PR
RW
I
N
S
G
--------
GL
G
T
MG
F
GLP
A
A
L
G
V
KM
A
L
P
EET
VVC
VT
GDG
SIQ
M
NIQ
E
LS
T
AL
Q
YE
LPV
L
V
V
NL
NN
RY
LG
M
V
K
-
QWQD
M
IYSGRHSQSYMQSL
-----------
PD
F
VR
LA
E
A
Y
G
HV
G
IQ
I
AHPQ
E
LES
K
L
SEALEQ
VRN
NR
L
VF
V
D
V
T
V
D
GS
--------
E
HVY
P
M
Q
IR
G
G
G
M
D
EMWLSKTERT
fig|656380.3.peg.257
Escherichia coli FVEC1412
MV
V
RS
L
IDQ
GV
KQ
V
F
G
YP
G
GA
V
LD
I
Y
D
A
L
HTV
-
G
G
I
D
H
V
LV
RHEQ
A
A
VHM
A
D
G
L
A
RAT
G
E
V
GV
--
V
LVT
SGPG
A
TN
A
ITG
I
A
T
A
YM
D
SI
PL
V
V
L
SG
QVATSL
IG
--
Y
D
A
FQE
C
D
MV
--------
GISRPVV
K
HSF
LV
KQT
ED
I
P
QV
L
KK
A
FWL
A
A
S
-
GRPG
P
V
V
VDLP
K
D
I
LNPANKLP
Y
I
W
PESVSMRSYNPT-
-
-TSGHKGQ
I
KR
A
LQT
L
VA
A
KK
P
V
V
YV
G
G
G
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
VVSS
L
M
GLG
AF
P
AT
H
R
QAL
GM
L
GM
H
G
TYEANMT
M
H
NAD
V
I
FA
VG
V
RF
DD
R
TTNNLAK
Y
C
P
-
NA
TV
L
HIDIDP
T
S
I
SKTVTAD
I
P
IVGD
ARQV
L
EQ
M
L
EL
L
SQESVHQ
PL
D
EI
RD
W
W
Q
QIEQW
R
ARQCLKYD--SHS
E
----------------------------
K
-
IKPQAVIET
L
WR
----
LTKGDAYV
T
S
DVG
QH
QM
F
AA
LY
-
YPFDK
PR
RW
I
N
S
G
--------
GL
G
T
MG
F
GLP
A
A
L
G
V
KM
A
L
P
EET
VVC
VT
GDG
SIQ
M
NIQ
E
LS
T
AL
Q
YE
LPV
L
V
V
NL
NN
RY
LG
M
V
K
-
QWQD
M
IYSGRHSQSYMQSL
-----------
PD
F
VR
LA
E
A
Y
G
HV
G
IQ
I
AHPQ
E
LES
K
L
SEALEQ
VRN
NR
L
VF
V
D
V
T
V
D
GS
--------
E
HVY
P
M
Q
IR
G
G
G
M
D
EMWLSKTERT
fig|749549.3.peg.4572
Escherichia coli MS 198-1
MV
V
RS
L
IDQ
GV
KQ
V
F
G
YP
G
GA
V
LD
I
Y
D
A
L
HTV
-
G
G
I
D
H
V
LV
RHEQ
A
A
VHM
A
D
G
L
A
RAT
G
E
V
GV
--
V
LVT
SGPG
A
TN
A
ITG
I
A
T
A
YM
D
SI
PL
V
V
L
SG
QVATSL
IG
--
Y
D
A
FQE
C
D
MV
--------
GISRPVV
K
HSF
LV
KQT
ED
I
P
QV
L
KK
A
FWL
A
A
S
-
GRPG
P
V
V
VDLP
K
D
I
LNPANKLP
Y
I
W
PESVSMRSYNPT-
-
-TSGHKGQ
I
KR
A
LQT
L
VA
A
KK
P
V
V
YV
G
G
G
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
VVSS
L
M
GLG
AF
P
AT
H
R
QAL
GM
L
GM
H
G
TYEANMT
M
H
NAD
V
I
FA
VG
V
RF
DD
R
TTNNLAK
Y
C
P
-
NA
TV
L
HIDIDP
T
S
I
SKTVTAD
I
P
IVGD
ARQV
L
EQ
M
L
EL
L
SQESVHQ
PL
D
EI
RD
W
W
Q
QIEQW
R
ARQCLKYD--SHS
E
----------------------------
K
-
IKPQAVIET
L
WR
----
LTKGDAYV
T
S
DVG
QH
QM
F
AA
LY
-
YPFDK
PR
RW
I
N
S
G
--------
GL
G
T
MG
F
GLP
A
A
L
G
V
KM
A
L
P
EET
VVC
VT
GDG
SIQ
M
NIQ
E
LS
T
AL
Q
YE
LPV
L
V
V
NL
NN
RY
LG
M
V
K
-
QWQD
M
IYSGRHSQSYMQSL
-----------
PD
F
VR
LA
E
A
Y
G
HV
G
IQ
I
AHPQ
E
LES
K
L
SEALEQ
VRN
NR
L
VF
V
D
V
T
V
D
GS
--------
E
HVY
P
M
Q
IR
G
G
G
M
D
EMWLSKTERT
fig|585056.7.peg.268
Escherichia coli UMN026
MV
V
RS
L
IDQ
GV
KQ
V
F
G
YP
G
GA
V
LD
I
Y
D
A
L
HTV
-
G
G
I
D
H
V
LV
RHEQ
A
A
VHM
A
D
G
L
A
RAT
G
E
V
GV
--
V
LVT
SGPG
A
TN
A
ITG
I
A
T
A
YM
D
SI
PL
V
V
L
SG
QVATSL
IG
--
Y
D
A
FQE
C
D
MV
--------
GISRPVV
K
HSF
LV
KQT
ED
I
P
QV
L
KK
A
FWL
A
A
S
-
GRPG
P
V
V
VDLP
K
D
I
LNPANKLP
Y
I
W
PESVSMRSYNPT-
-
-TSGHKGQ
I
KR
A
LQT
L
VA
A
KK
P
V
V
YV
G
G
G
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
VVSS
L
M
GLG
AF
P
AT
H
R
QAL
GM
L
GM
H
G
TYEANMT
M
H
NAD
V
I
FA
VG
V
RF
DD
R
TTNNLAK
Y
C
P
-
NA
TV
L
HIDIDP
T
S
I
SKTVTAD
I
P
IVGD
ARQV
L
EQ
M
L
EL
L
SQESVHQ
PL
D
EI
RD
W
W
Q
QIEQW
R
ARQCLKYD--SHS
E
----------------------------
K
-
IKPQAVIET
L
WR
----
LTKGDAYV
T
S
DVG
QH
QM
F
AA
LY
-
YPFDK
PR
RW
I
N
S
G
--------
GL
G
T
MG
F
GLP
A
A
L
G
V
KM
A
L
P
EET
VVC
VT
GDG
SIQ
M
NIQ
E
LS
T
AL
Q
YE
LPV
L
V
V
NL
NN
RY
LG
M
V
K
-
QWQD
M
IYSGRHSQSYMQSL
-----------
PD
F
VR
LA
E
A
Y
G
HV
G
IQ
I
AHPQ
E
LES
K
L
SEALEQ
VRN
NR
L
VF
V
D
V
T
V
D
GS
--------
E
HVY
P
M
Q
IR
G
G
G
M
D
EMWLSKTERT
fig|749527.3.peg.3177
Escherichia coli MS 21-1 (9-574/574)
MV
V
RS
L
IDQ
GV
KQ
V
F
G
YP
G
GA
V
LD
I
Y
D
A
L
HTV
-
G
G
I
D
H
V
LV
RHEQ
A
A
VHM
A
D
G
L
A
RAT
G
E
V
GV
--
V
LVT
SGPG
A
TN
A
ITG
I
A
T
A
YM
D
SI
PL
V
V
L
SG
QVATSL
IG
--
Y
D
A
FQE
C
D
MV
--------
GISRPVV
K
HSF
LV
KQT
ED
I
P
QV
L
KK
A
FWL
A
A
S
-
GRPG
P
V
V
VDLP
K
D
I
LNPANKLP
YVW
PESVSMRSYNPT-
-
-TSGHKGQ
I
KR
A
LQT
L
VA
A
KK
P
V
V
YV
G
G
G
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
VVSS
L
M
GLG
AF
P
AT
H
R
QAL
GM
L
GM
H
G
TYEANMT
M
H
NAD
V
I
FA
VG
V
RF
DD
R
TTNNLAK
Y
C
P
-
NA
TV
L
HIDIDP
T
S
I
SKTVTAD
I
P
IVGD
ARQV
L
EQ
M
L
EL
L
SQESVHQ
PL
D
EI
RD
W
W
Q
QIEQW
R
VRQCLKYD--SHS
E
----------------------------
K
-
IKPQAVIET
L
WR
----
LTKGDAYV
T
S
DVG
QH
QM
F
AA
LY
-
YPFDK
PR
RW
I
N
S
G
--------
GL
G
T
MG
F
GLP
A
A
L
G
V
KM
A
L
P
EET
VVC
VT
GDG
SIQ
M
NIQ
E
LS
T
AL
Q
YE
LPV
L
V
V
NL
NN
RY
LG
M
V
K
-
QWQD
M
IYSGRHSQSYMQSL
-----------
PD
F
VR
LA
E
A
Y
G
HV
G
IQ
I
SHPQ
E
LES
K
L
SEALEQ
VRN
NR
L
VF
V
D
V
T
V
D
GS
--------
E
HVY
P
M
Q
IR
G
G
G
M
D
EMWLSKTERT
fig|656444.3.peg.414
Escherichia coli TA280
MV
V
RS
L
IDQ
GV
KQ
V
F
G
YP
G
GA
V
LD
I
Y
D
A
L
HTV
-
G
G
I
D
H
V
LV
RHEQ
A
A
VHM
A
D
G
L
A
RAT
G
E
V
GV
--
V
LVT
SGPG
A
TN
A
ITG
I
A
T
A
YM
D
SI
PL
V
V
L
SG
QVATSL
IG
--
Y
D
A
FQE
C
D
MV
--------
GISRPVV
K
HSF
LV
KQT
ED
I
P
QV
L
KK
A
FWL
A
A
S
-
GRPG
P
V
V
VDLP
K
D
I
LNPANKLP
YVW
PESVSMRSYNPT-
-
-TSGHKGQ
I
KR
A
LQT
L
VA
A
KK
P
V
V
YV
G
G
G
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
VVSS
L
M
GLG
VF
P
AT
H
R
QAL
GM
L
GM
H
G
TYEANMT
M
H
NAD
V
I
FA
VG
V
RF
DD
R
TTNNLAK
Y
C
P
-
NA
TV
L
HIDIDP
T
S
I
SKTVTAD
I
P
IVGD
ARQV
L
EQ
M
L
EL
L
SQESVHQ
PL
D
EI
RD
W
W
Q
QIEQW
R
ARQCLKYD--SHS
E
----------------------------
K
-
IKPQAVIET
L
WR
----
LTKGDAYV
T
S
DVG
QH
QM
F
AA
LY
-
YPFDK
PR
RW
I
N
S
G
--------
GL
G
T
MG
F
GLP
A
A
L
G
V
KM
A
L
P
EET
VVC
VT
GDG
SIQ
M
NIQ
E
LS
T
AL
Q
YE
LPV
L
V
V
NL
NN
RY
LG
M
V
K
-
QWQD
M
IYSGRHSQSYMQSL
-----------
PD
F
VR
LA
E
A
Y
G
HV
G
IQ
I
SHPQ
E
LES
K
L
SEALEQ
VRN
NR
L
VF
V
D
V
T
V
D
GS
--------
E
HVY
P
M
Q
IR
G
G
G
M
D
EMWLSKTERT
fig|550677.3.peg.467
Escherichia coli B354 (9-574/574)
MV
V
RS
L
IDQ
GV
KQ
V
F
G
YP
G
GA
V
LD
I
Y
D
A
L
HTV
-
G
G
I
D
H
V
LV
RHEQ
A
A
VHM
A
D
G
L
A
RAT
G
E
V
GV
--
V
LVT
SGPG
A
TN
A
ITG
I
A
T
A
YM
D
SI
PL
V
V
L
SG
QVATSL
IG
--
Y
D
A
FQE
C
D
MV
--------
GISRPVV
K
HSF
LV
KQT
ED
I
P
QV
L
KK
A
FWL
A
A
S
-
GRPG
P
V
V
VDLP
K
D
I
LNPANKLP
YVW
PESVSMRSYNPT-
-
-TSGHKGQ
I
KR
A
LQT
L
VA
A
KK
P
V
V
YV
G
G
G
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
VVSS
L
M
GLG
AF
P
AT
H
R
QAL
GM
L
GM
H
G
TYEANMT
M
H
NAD
V
I
FA
VG
V
RF
DD
R
TTNNLAK
Y
C
P
-
NA
TV
L
HIDIDP
T
S
I
SKTVTAD
I
P
IVGD
ARQV
L
EQ
M
L
EL
L
SQESVHQ
PL
D
EI
RD
W
W
Q
QIEQW
R
ARQCLKYD--SYS
E
----------------------------
K
-
IKPQAVIET
L
WR
----
LTKGDAYV
T
S
DVG
QH
QM
F
AA
LY
-
YPFDK
PR
RW
I
N
S
G
--------
GL
G
T
MG
F
GLP
A
A
L
G
V
KM
A
L
P
EET
VVC
VT
GDG
SIQ
M
NIQ
E
LS
T
AL
Q
YE
LPV
L
V
V
NL
NN
RY
LG
M
V
K
-
QWQD
M
IYSGRHSQSYMQSL
-----------
PD
F
VR
LA
E
A
Y
G
HV
G
IQ
I
SHPQ
E
LES
K
L
SEALEQ
VRN
NR
L
VF
V
D
V
T
V
D
GS
--------
E
HVY
P
M
Q
IR
G
G
G
M
D
EMWLSKTERT
fig|656437.3.peg.140
Escherichia coli TA143
MV
V
RS
L
IDQ
GV
KQ
V
F
G
YP
G
GA
V
LD
I
Y
D
A
L
HTV
-
G
G
I
D
H
V
LV
RHEQ
A
A
VHM
A
D
G
L
A
RAT
G
E
V
GV
--
V
LVT
SGPG
A
TN
A
ITG
I
A
T
A
YM
D
SI
PL
V
V
L
SG
QVATSL
IG
--
Y
D
A
FQE
C
D
MV
--------
GISRPVV
K
HSF
LV
KQT
ED
I
P
QV
L
KK
A
FWL
A
A
S
-
GRPG
P
V
V
VDLP
K
D
I
LNPANKLP
Y
I
W
PESVSMRSYNPT-
-
-TSGHKGQ
I
KR
A
LQT
L
VA
A
KK
P
V
V
YV
G
G
G
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
VVSS
L
M
GLG
AF
P
AT
H
R
QAL
GM
L
GM
H
G
TYEANMT
M
H
NAD
V
I
FA
VG
V
RF
DD
R
TTNNLAK
Y
C
P
-
NA
TV
L
HIDIDP
T
S
I
SKTVTAD
I
P
IVGD
ARQV
L
EQ
M
L
EL
L
SQESVHQ
PL
D
EI
RD
W
W
Q
QIEQW
R
ARQCLKYD--SYS
E
----------------------------
K
-
IKPQAVIET
L
WR
----
LTKGDAYV
T
S
DVG
QH
QM
F
AA
LY
-
YPFDK
PR
RW
I
N
S
G
--------
GL
G
T
MG
F
GLP
A
A
L
G
V
KM
A
L
P
EET
VVC
VT
GDG
SIQ
M
NIQ
E
LS
T
AL
Q
YE
LPV
L
V
V
NL
NN
RY
LG
M
V
K
-
QWQD
M
IYSGRHSQSYMQSL
-----------
PD
F
VR
LA
E
A
Y
G
HV
G
IQ
I
SHPQ
E
LES
K
L
SEALEQ
VRN
NR
L
VF
V
D
V
T
V
D
GS
--------
E
HVY
P
M
Q
IR
G
G
G
M
D
EMWLSKTERT
fig|362663.8.peg.85
Escherichia coli 536
MV
V
RS
L
IDQ
GV
KQ
V
F
G
YP
G
GA
V
LD
I
Y
D
A
L
HTV
-
G
G
I
D
H
V
LV
RHEQ
A
A
VHM
A
D
G
L
A
RAT
G
E
V
GV
--
V
LVT
SGPG
A
TN
A
ITG
I
A
T
A
YM
D
SI
PL
V
V
L
SG
QVATSL
IG
--
Y
D
A
FQE
C
D
MV
--------
GISRPVV
K
HSF
LV
KQT
ED
I
P
QV
L
KK
A
FWL
A
A
S
-
GRPG
P
V
V
VDLP
K
D
I
LNPANKLP
YVW
PESVSMRSYNPT-
-
-TSGHKGQ
I
KR
A
LQT
L
VA
A
KK
P
V
V
YV
G
G
G
AIT
A
G
C
HLQ
L
K
E
AVEALNL
P
VVSS
L
M
GLG
AF
P
AT
H
R
QAL
GM
L
GM
H
G
TYEANMT
M
H
NAD
V
I
FA
VG
V
RF
DD
R
TTNNLAK
Y
C
P
-
NA
TV
L
HIDIDP
T
S
I
SKTVTAD
I
P
IVGD
ARQV
L
EQ
M
L
EL
L
SQESAHQ
PL
D
EI
RD
W
W
Q
QIEQW
R
ARQCLKYD--THS
E
----------------------------
K
-
IKPQAVIET
L
WR
----
LTNGDAYV
T
S
DVG
QH
QM
F
AA
LY
-
YPFDK
PR
RW
I
N
S
G
--------
GL
G
T
MG
F
GLP
A
A
L
G
V
KM
A
L
P
EET
VVC
VT
GDG
SIQ
M
NIQ
E
LS
T
AL
Q
YE
LPV
L
V
V
NL
NN
RY
LG
M
V
K
-
QWQD
M
IYSGRHSQSYMQSL
-----------
PD
F
VR
LA
E
A
Y
G
HV
G
IQ
I
SHPQ
E
LES
K
L
SEALEQ
VRN
NR
L
VF
V
D
V
T
V
D
GS
--------
E
HVY
P
M
Q
IR
G
G
G
M
D
EMWLSKTERT
fig|362663.9.peg.85
Escherichia coli 536
MV
V
RS
L
IDQ
GV
KQ
V
F
G
YP
G
GA
V
LD
I
Y
D
A
L
HTV
-
G
G
I
D
H
V
LV
RHEQ
A
A
VHM
A
D
G
L
A
RAT
G
E
V
GV
--
V
LVT
SGPG
A
TN
A
ITG
I
A
T
A
YM
D
SI
PL
V
V
L
SG
QVATSL
IG
--
Y
D
A
FQE
C
D
MV
--------
GISRPVV
K
HSF
LV
KQT
ED
I
P
QV
L
KK
A
FWL
A
A
S
-
GRPG
P
V
V
VDLP
K
D
I
LNPANKLP
YVW
PESVSMRSYNPT-
-
-TSGHKGQ
I
KR
A
LQT
L
VA
A
KK
P
V
V
YV
G
G
G
AIT
A
G
C
HLQ
L
K
E
AVEALNL
P
VVSS
L
M
GLG
AF
P
AT
H
R
QAL
GM
L
GM
H
G
TYEANMT
M
H
NAD
V
I
FA
VG
V
RF
DD
R
TTNNLAK
Y
C
P
-
NA
TV
L
HIDIDP
T
S
I
SKTVTAD
I
P
IVGD
ARQV
L
EQ
M
L
EL
L
SQESAHQ
PL
D
EI
RD
W
W
Q
QIEQW
R
ARQCLKYD--THS
E
----------------------------
K
-
IKPQAVIET
L
WR
----
LTNGDAYV
T
S
DVG
QH
QM
F
AA
LY
-
YPFDK
PR
RW
I
N
S
G
--------
GL
G
T
MG
F
GLP
A
A
L
G
V
KM
A
L
P
EET
VVC
VT
GDG
SIQ
M
NIQ
E
LS
T
AL
Q
YE
LPV
L
V
V
NL
NN
RY
LG
M
V
K
-
QWQD
M
IYSGRHSQSYMQSL
-----------
PD
F
VR
LA
E
A
Y
G
HV
G
IQ
I
SHPQ
E
LES
K
L
SEALEQ
VRN
NR
L
VF
V
D
V
T
V
D
GS
--------
E
HVY
P
M
Q
IR
G
G
G
M
D
EMWLSKTERT
fig|340197.3.peg.4332
Escherichia coli F11 (37-602/602)
MV
V
RS
L
IDQ
GV
KQ
V
F
G
YP
G
GA
V
LD
I
Y
D
A
L
HTV
-
G
G
I
D
H
V
LV
RHEQ
A
A
VHM
A
D
G
L
A
RAT
G
E
V
GV
--
V
LVT
SGPG
A
TN
A
ITG
I
A
T
A
YM
D
SI
PL
V
V
L
SG
QVATSL
IG
--
Y
D
A
FQE
C
D
MV
--------
GISRPVV
K
HSF
LV
KQT
ED
I
P
QV
L
KK
A
FWL
A
A
S
-
GRPG
P
V
V
VDLP
K
D
I
LNPANKLP
YVW
PESVSMRSYNPT-
-
-TSGHKGQ
I
KR
A
LQT
L
VA
A
KK
P
V
V
YV
G
G
G
AIT
A
G
C
HLQ
L
K
E
AVEALNL
P
VVSS
L
M
GLG
AF
P
AT
H
R
QAL
GM
L
GM
H
G
TYEANMT
M
H
NAD
V
I
FA
VG
V
RF
DD
R
TTNNLAK
Y
C
P
-
NA
TV
L
HIDIDP
T
S
I
SKTVTAD
I
P
IVGD
ARQV
L
EQ
M
L
EL
L
SQESAHQ
PL
D
EI
RD
W
W
Q
QIEQW
R
ARQCLKYD--THS
E
----------------------------
K
-
IKPQAVIET
L
WR
----
LTNGDAYV
T
S
DVG
QH
QM
F
AA
LY
-
YPFDK
PR
RW
I
N
S
G
--------
GL
G
T
MG
F
GLP
A
A
L
G
V
KM
A
L
P
EET
VVC
VT
GDG
SIQ
M
NIQ
E
LS
T
AL
Q
YE
LPV
L
V
V
NL
NN
RY
LG
M
V
K
-
QWQD
M
IYSGRHSQSYMQSL
-----------
PD
F
VR
LA
E
A
Y
G
HV
G
IQ
I
SHPQ
E
LES
K
L
SEALEQ
VRN
NR
L
VF
V
D
V
T
V
D
GS
--------
E
HVY
P
M
Q
IR
G
G
G
M
D
EMWLSKTERT
fig|340197.5.peg.4525
Escherichia coli F11
MV
V
RS
L
IDQ
GV
KQ
V
F
G
YP
G
GA
V
LD
I
Y
D
A
L
HTV
-
G
G
I
D
H
V
LV
RHEQ
A
A
VHM
A
D
G
L
A
RAT
G
E
V
GV
--
V
LVT
SGPG
A
TN
A
ITG
I
A
T
A
YM
D
SI
PL
V
V
L
SG
QVATSL
IG
--
Y
D
A
FQE
C
D
MV
--------
GISRPVV
K
HSF
LV
KQT
ED
I
P
QV
L
KK
A
FWL
A
A
S
-
GRPG
P
V
V
VDLP
K
D
I
LNPANKLP
YVW
PESVSMRSYNPT-
-
-TSGHKGQ
I
KR
A
LQT
L
VA
A
KK
P
V
V
YV
G
G
G
AIT
A
G
C
HLQ
L
K
E
AVEALNL
P
VVSS
L
M
GLG
AF
P
AT
H
R
QAL
GM
L
GM
H
G
TYEANMT
M
H
NAD
V
I
FA
VG
V
RF
DD
R
TTNNLAK
Y
C
P
-
NA
TV
L
HIDIDP
T
S
I
SKTVTAD
I
P
IVGD
ARQV
L
EQ
M
L
EL
L
SQESAHQ
PL
D
EI
RD
W
W
Q
QIEQW
R
ARQCLKYD--THS
E
----------------------------
K
-
IKPQAVIET
L
WR
----
LTNGDAYV
T
S
DVG
QH
QM
F
AA
LY
-
YPFDK
PR
RW
I
N
S
G
--------
GL
G
T
MG
F
GLP
A
A
L
G
V
KM
A
L
P
EET
VVC
VT
GDG
SIQ
M
NIQ
E
LS
T
AL
Q
YE
LPV
L
V
V
NL
NN
RY
LG
M
V
K
-
QWQD
M
IYSGRHSQSYMQSL
-----------
PD
F
VR
LA
E
A
Y
G
HV
G
IQ
I
SHPQ
E
LES
K
L
SEALEQ
VRN
NR
L
VF
V
D
V
T
V
D
GS
--------
E
HVY
P
M
Q
IR
G
G
G
M
D
EMWLSKTERT
fig|749550.3.peg.2596
Escherichia coli MS 200-1
MV
V
RS
L
IDQ
GV
KQ
V
F
G
YP
G
GA
V
LD
I
Y
D
A
L
HTV
-
G
G
I
D
H
V
LV
RHEQ
A
A
VHM
A
D
G
L
A
RAT
G
E
V
GV
--
V
LVT
SGPG
A
TN
A
ITG
I
A
T
A
YM
D
SI
PL
V
V
L
SG
QVATSL
IG
--
Y
D
A
FQE
C
D
MV
--------
GISRPVV
K
HSF
LV
KQT
ED
I
P
QV
L
KK
A
FWL
A
A
S
-
GRPG
P
V
V
VDLP
K
D
I
LNPANKLP
YVW
PESVSMRSYNPT-
-
-TSGHKGQ
I
KR
A
LQT
L
VA
A
KK
P
V
V
YV
G
G
G
AIT
A
G
C
HLQ
L
K
E
AVEALNL
P
VVSS
L
M
GLG
AF
P
AT
H
R
QAL
GM
L
GM
H
G
TYEANMT
M
H
NAD
V
I
FA
VG
V
RF
DD
R
TTNNLAK
Y
C
P
-
NA
TV
L
HIDIDP
T
S
I
SKTVTAD
I
P
IVGD
ARQV
L
EQ
M
L
EL
L
SQESAHQ
PL
D
EI
RD
W
W
Q
QIEQW
R
ARQCLKYD--THS
E
----------------------------
K
-
IKPQAVIET
L
WR
----
LTNGDAYV
T
S
DVG
QH
QM
F
AA
LY
-
YPFDK
PR
RW
I
N
S
G
--------
GL
G
T
MG
F
GLP
A
A
L
G
V
KM
A
L
P
EET
VVC
VT
GDG
SIQ
M
NIQ
E
LS
T
AL
Q
YE
LPV
L
V
V
NL
NN
RY
LG
M
V
K
-
QWQD
M
IYSGRHSQSYMQSL
-----------
PD
F
VR
LA
E
A
Y
G
HV
G
IQ
I
SHPQ
E
LES
K
L
SEALEQ
VRN
NR
L
VF
V
D
V
T
V
D
GS
--------
E
HVY
P
M
Q
IR
G
G
G
M
D
EMWLSKTERT
fig|525281.3.peg.1190
Escherichia coli 83972
MV
V
RS
L
IDQ
GV
KQ
V
F
G
YP
G
GA
V
LD
I
Y
D
A
L
HTV
-
G
G
I
D
H
V
LV
RHEQ
A
A
VHM
A
D
G
L
A
RAT
G
E
V
GV
--
V
LVT
SGPG
A
TN
A
ITG
I
A
T
A
YM
D
SI
PL
V
V
L
SG
QVATSL
IG
--
Y
D
A
FQE
C
D
MV
--------
GISRPVV
K
HSF
LV
KQT
ED
I
P
QV
L
KK
A
FWL
A
A
S
-
GRPG
P
V
V
VDLP
K
D
I
LNPANKLP
YVW
PESVSMRSYNPT-
-
-TSGHKGQ
I
KR
A
LQT
L
VA
A
KK
P
V
V
YV
G
G
G
AIT
A
G
C
HLQ
L
K
E
AVEVLNL
P
VVSS
L
M
GLG
AF
P
AT
H
R
QAL
GM
L
GM
H
G
TYEANMT
M
H
NAD
V
I
FA
VG
V
RF
DD
R
TTNNLAK
Y
C
P
-
NA
TV
L
HIDIDP
T
S
I
SKTVTAD
I
P
IVGD
ARQV
L
EQ
M
L
EL
L
SQESAHQ
PL
D
EI
RD
W
W
Q
QIEQW
R
ARQCLKYD--THS
E
----------------------------
K
-
IKPQAVIET
L
WR
----
LTNGDAYV
T
S
DVG
QH
QM
F
AA
LY
-
YPFDK
PR
RW
I
N
S
G
--------
GL
G
T
MG
F
GLP
A
A
L
G
V
KM
A
L
P
EET
VVC
VT
GDG
SIQ
M
NIQ
E
LS
T
AL
Q
YE
LPV
L
V
V
NL
NN
RY
LG
M
V
K
-
QWQD
M
IYSGRHSQSYMQSL
-----------
PD
F
VR
LA
E
A
Y
G
HV
G
IQ
I
SHPQ
E
LES
K
L
SEALEQ
VRN
NR
L
VF
V
D
V
T
V
D
GS
--------
E
HVY
P
M
Q
IR
G
G
G
M
D
EMWLSKTERT
fig|655817.3.peg.89
Escherichia coli ABU 83972
MV
V
RS
L
IDQ
GV
KQ
V
F
G
YP
G
GA
V
LD
I
Y
D
A
L
HTV
-
G
G
I
D
H
V
LV
RHEQ
A
A
VHM
A
D
G
L
A
RAT
G
E
V
GV
--
V
LVT
SGPG
A
TN
A
ITG
I
A
T
A
YM
D
SI
PL
V
V
L
SG
QVATSL
IG
--
Y
D
A
FQE
C
D
MV
--------
GISRPVV
K
HSF
LV
KQT
ED
I
P
QV
L
KK
A
FWL
A
A
S
-
GRPG
P
V
V
VDLP
K
D
I
LNPANKLP
YVW
PESVSMRSYNPT-
-
-TSGHKGQ
I
KR
A
LQT
L
VA
A
KK
P
V
V
YV
G
G
G
AIT
A
G
C
HLQ
L
K
E
AVEVLNL
P
VVSS
L
M
GLG
AF
P
AT
H
R
QAL
GM
L
GM
H
G
TYEANMT
M
H
NAD
V
I
FA
VG
V
RF
DD
R
TTNNLAK
Y
C
P
-
NA
TV
L
HIDIDP
T
S
I
SKTVTAD
I
P
IVGD
ARQV
L
EQ
M
L
EL
L
SQESAHQ
PL
D
EI
RD
W
W
Q
QIEQW
R
ARQCLKYD--THS
E
----------------------------
K
-
IKPQAVIET
L
WR
----
LTNGDAYV
T
S
DVG
QH
QM
F
AA
LY
-
YPFDK
PR
RW
I
N
S
G
--------
GL
G
T
MG
F
GLP
A
A
L
G
V
KM
A
L
P
EET
VVC
VT
GDG
SIQ
M
NIQ
E
LS
T
AL
Q
YE
LPV
L
V
V
NL
NN
RY
LG
M
V
K
-
QWQD
M
IYSGRHSQSYMQSL
-----------
PD
F
VR
LA
E
A
Y
G
HV
G
IQ
I
SHPQ
E
LES
K
L
SEALEQ
VRN
NR
L
VF
V
D
V
T
V
D
GS
--------
E
HVY
P
M
Q
IR
G
G
G
M
D
EMWLSKTERT
fig|199310.1.peg.92
Escherichia coli CFT073 (39-604/604)
MV
V
RS
L
IDQ
GV
KQ
V
F
G
YP
G
GA
V
LD
I
Y
D
A
L
HTV
-
G
G
I
D
H
V
LV
RHEQ
A
A
VHM
A
D
G
L
A
RAT
G
E
V
GV
--
V
LVT
SGPG
A
TN
A
ITG
I
A
T
A
YM
D
SI
PL
V
V
L
SG
QVATSL
IG
--
Y
D
A
FQE
C
D
MV
--------
GISRPVV
K
HSF
LV
KQT
ED
I
P
QV
L
KK
A
FWL
A
A
S
-
GRPG
P
V
V
VDLP
K
D
I
LNPANKLP
YVW
PESVSMRSYNPT-
-
-TSGHKGQ
I
KR
A
LQT
L
VA
A
KK
P
V
V
YV
G
G
G
AIT
A
G
C
HLQ
L
K
E
AVEVLNL
P
VVSS
L
M
GLG
AF
P
AT
H
R
QAL
GM
L
GM
H
G
TYEANMT
M
H
NAD
V
I
FA
VG
V
RF
DD
R
TTNNLAK
Y
C
P
-
NA
TV
L
HIDIDP
T
S
I
SKTVTAD
I
P
IVGD
ARQV
L
EQ
M
L
EL
L
SQESAHQ
PL
D
EI
RD
W
W
Q
QIEQW
R
ARQCLKYD--THS
E
----------------------------
K
-
IKPQAVIET
L
WR
----
LTNGDAYV
T
S
DVG
QH
QM
F
AA
LY
-
YPFDK
PR
RW
I
N
S
G
--------
GL
G
T
MG
F
GLP
A
A
L
G
V
KM
A
L
P
EET
VVC
VT
GDG
SIQ
M
NIQ
E
LS
T
AL
Q
YE
LPV
L
V
V
NL
NN
RY
LG
M
V
K
-
QWQD
M
IYSGRHSQSYMQSL
-----------
PD
F
VR
LA
E
A
Y
G
HV
G
IQ
I
SHPQ
E
LES
K
L
SEALEQ
VRN
NR
L
VF
V
D
V
T
V
D
GS
--------
E
HVY
P
M
Q
IR
G
G
G
M
D
EMWLSKTERT
fig|199310.4.peg.89
Escherichia coli CFT073
MV
V
RS
L
IDQ
GV
KQ
V
F
G
YP
G
GA
V
LD
I
Y
D
A
L
HTV
-
G
G
I
D
H
V
LV
RHEQ
A
A
VHM
A
D
G
L
A
RAT
G
E
V
GV
--
V
LVT
SGPG
A
TN
A
ITG
I
A
T
A
YM
D
SI
PL
V
V
L
SG
QVATSL
IG
--
Y
D
A
FQE
C
D
MV
--------
GISRPVV
K
HSF
LV
KQT
ED
I
P
QV
L
KK
A
FWL
A
A
S
-
GRPG
P
V
V
VDLP
K
D
I
LNPANKLP
YVW
PESVSMRSYNPT-
-
-TSGHKGQ
I
KR
A
LQT
L
VA
A
KK
P
V
V
YV
G
G
G
AIT
A
G
C
HLQ
L
K
E
AVEVLNL
P
VVSS
L
M
GLG
AF
P
AT
H
R
QAL
GM
L
GM
H
G
TYEANMT
M
H
NAD
V
I
FA
VG
V
RF
DD
R
TTNNLAK
Y
C
P
-
NA
TV
L
HIDIDP
T
S
I
SKTVTAD
I
P
IVGD
ARQV
L
EQ
M
L
EL
L
SQESAHQ
PL
D
EI
RD
W
W
Q
QIEQW
R
ARQCLKYD--THS
E
----------------------------
K
-
IKPQAVIET
L
WR
----
LTNGDAYV
T
S
DVG
QH
QM
F
AA
LY
-
YPFDK
PR
RW
I
N
S
G
--------
GL
G
T
MG
F
GLP
A
A
L
G
V
KM
A
L
P
EET
VVC
VT
GDG
SIQ
M
NIQ
E
LS
T
AL
Q
YE
LPV
L
V
V
NL
NN
RY
LG
M
V
K
-
QWQD
M
IYSGRHSQSYMQSL
-----------
PD
F
VR
LA
E
A
Y
G
HV
G
IQ
I
SHPQ
E
LES
K
L
SEALEQ
VRN
NR
L
VF
V
D
V
T
V
D
GS
--------
E
HVY
P
M
Q
IR
G
G
G
M
D
EMWLSKTERT
fig|585397.7.peg.85
Escherichia coli ED1a
MV
V
RS
L
IDQ
GV
KQ
V
F
G
YP
G
GA
V
LD
I
Y
D
A
L
HTV
-
G
G
I
D
H
V
LV
RHEQ
A
A
VHM
A
D
G
L
A
RAT
G
E
V
GV
--
V
LVT
SGPG
A
TN
A
ITG
I
A
T
A
YM
D
SI
PL
V
V
L
SG
QVATSL
IG
--
Y
D
A
FQE
C
D
MV
--------
GISRPVV
K
HSF
LV
KQT
ED
I
P
QV
L
KK
A
FWL
A
A
S
-
GRPG
P
V
V
VDLP
K
D
I
LNPANKLP
YVW
PESVSMRSYNPT-
-
-TSGHKGQ
I
KR
A
LQT
L
VA
A
KK
P
V
V
YV
G
G
G
AIT
A
G
C
HLQ
L
K
E
AVEVLNL
P
VVSS
L
M
GLG
AF
P
AT
H
R
QAL
GM
L
GM
H
G
TYEANMT
M
H
NAD
V
I
FA
VG
V
RF
DD
R
TTNNLAK
Y
C
P
-
NA
TV
L
HIDIDP
T
S
I
SKTVTAD
I
P
IVGD
ARQV
L
EQ
M
L
EL
L
SQESAHQ
PL
D
EI
RD
W
W
Q
QIEQW
R
ARQCLKYD--THS
E
----------------------------
K
-
IKPQAVIET
L
WR
----
LTNGDAYV
T
S
DVG
QH
QM
F
AA
LY
-
YPFDK
PR
RW
I
N
S
G
--------
GL
G
T
MG
F
GLP
A
A
L
G
V
KM
A
L
P
EET
VVC
VT
GDG
SIQ
M
NIQ
E
LS
T
AL
Q
YE
LPV
L
V
V
NL
NN
RY
LG
M
V
K
-
QWQD
M
IYSGRHSQSYMQSL
-----------
PD
F
VR
LA
E
A
Y
G
HV
G
IQ
I
SHPQ
E
LES
K
L
SEALEQ
VRN
NR
L
VF
V
D
V
T
V
D
GS
--------
E
HVY
P
M
Q
IR
G
G
G
M
D
EMWLSKTERT
fig|585397.9.peg.85
Escherichia coli ED1a
MV
V
RS
L
IDQ
GV
KQ
V
F
G
YP
G
GA
V
LD
I
Y
D
A
L
HTV
-
G
G
I
D
H
V
LV
RHEQ
A
A
VHM
A
D
G
L
A
RAT
G
E
V
GV
--
V
LVT
SGPG
A
TN
A
ITG
I
A
T
A
YM
D
SI
PL
V
V
L
SG
QVATSL
IG
--
Y
D
A
FQE
C
D
MV
--------
GISRPVV
K
HSF
LV
KQT
ED
I
P
QV
L
KK
A
FWL
A
A
S
-
GRPG
P
V
V
VDLP
K
D
I
LNPANKLP
YVW
PESVSMRSYNPT-
-
-TSGHKGQ
I
KR
A
LQT
L
VA
A
KK
P
V
V
YV
G
G
G
AIT
A
G
C
HLQ
L
K
E
AVEVLNL
P
VVSS
L
M
GLG
AF
P
AT
H
R
QAL
GM
L
GM
H
G
TYEANMT
M
H
NAD
V
I
FA
VG
V
RF
DD
R
TTNNLAK
Y
C
P
-
NA
TV
L
HIDIDP
T
S
I
SKTVTAD
I
P
IVGD
ARQV
L
EQ
M
L
EL
L
SQESAHQ
PL
D
EI
RD
W
W
Q
QIEQW
R
ARQCLKYD--THS
E
----------------------------
K
-
IKPQAVIET
L
WR
----
LTNGDAYV
T
S
DVG
QH
QM
F
AA
LY
-
YPFDK
PR
RW
I
N
S
G
--------
GL
G
T
MG
F
GLP
A
A
L
G
V
KM
A
L
P
EET
VVC
VT
GDG
SIQ
M
NIQ
E
LS
T
AL
Q
YE
LPV
L
V
V
NL
NN
RY
LG
M
V
K
-
QWQD
M
IYSGRHSQSYMQSL
-----------
PD
F
VR
LA
E
A
Y
G
HV
G
IQ
I
SHPQ
E
LES
K
L
SEALEQ
VRN
NR
L
VF
V
D
V
T
V
D
GS
--------
E
HVY
P
M
Q
IR
G
G
G
M
D
EMWLSKTERT
fig|749546.3.peg.2386
Escherichia coli MS 185-1
MV
V
RS
L
IDQ
GV
KQ
V
F
G
YP
G
GA
V
LD
I
Y
D
A
L
HTV
-
G
G
I
D
H
V
LV
RHEQ
A
A
VHM
A
D
G
L
A
RAT
G
E
V
GV
--
V
LVT
SGPG
A
TN
A
ITG
I
A
T
A
YM
D
SI
PL
V
V
L
SG
QVATSL
IG
--
Y
D
A
FQE
C
D
MV
--------
GISRPVV
K
HSF
LV
KQT
ED
I
P
QV
L
KK
A
FWL
A
A
S
-
GRPG
P
V
V
VDLP
K
D
I
LNPANKLP
YVW
PESVSMRSYNPT-
-
-TSGHKGQ
I
KR
A
LQT
L
VA
A
KK
P
V
V
YV
G
G
G
AIT
A
G
C
HLQ
L
K
E
AVEVLNL
P
VVSS
L
M
GLG
AF
P
AT
H
R
QAL
GM
L
GM
H
G
TYEANMT
M
H
NAD
V
I
FA
VG
V
RF
DD
R
TTNNLAK
Y
C
P
-
NA
TV
L
HIDIDP
T
S
I
SKTVTAD
I
P
IVGD
ARQV
L
EQ
M
L
EL
L
SQESAHQ
PL
D
EI
RD
W
W
Q
QIEQW
R
ARQCLKYD--THS
E
----------------------------
K
-
IKPQAVIET
L
WR
----
LTNGDAYV
T
S
DVG
QH
QM
F
AA
LY
-
YPFDK
PR
RW
I
N
S
G
--------
GL
G
T
MG
F
GLP
A
A
L
G
V
KM
A
L
P
EET
VVC
VT
GDG
SIQ
M
NIQ
E
LS
T
AL
Q
YE
LPV
L
V
V
NL
NN
RY
LG
M
V
K
-
QWQD
M
IYSGRHSQSYMQSL
-----------
PD
F
VR
LA
E
A
Y
G
HV
G
IQ
I
SHPQ
E
LES
K
L
SEALEQ
VRN
NR
L
VF
V
D
V
T
V
D
GS
--------
E
HVY
P
M
Q
IR
G
G
G
M
D
EMWLSKTERT
fig|749528.3.peg.2231
Escherichia coli MS 45-1 (9-574/574)
MV
V
RS
L
IDQ
GV
KQ
V
F
G
YP
G
GA
V
LD
I
Y
D
A
L
HTV
-
G
G
I
D
H
V
LV
RHEQ
A
A
VHM
A
D
G
L
A
RAT
G
E
V
GV
--
V
LVT
SGPG
A
TN
A
ITG
I
A
T
A
YM
D
SI
PL
V
V
L
SG
QVATSL
IG
--
Y
D
A
FQE
C
D
MV
--------
GISRPVV
K
HSF
LV
KQT
ED
I
P
QV
L
KK
A
FWL
A
A
S
-
GRPG
P
V
V
VDLP
K
D
I
LNPANKLP
YVW
PESVSMRSYNPT-
-
-TSGHKGQ
I
KR
A
LQT
L
VA
A
KK
P
V
V
YV
G
G
G
AIT
A
G
C
HLQ
L
K
E
AVEVLNL
P
VVSS
L
M
GLG
AF
P
AT
H
R
QAL
GM
L
GM
H
G
TYEANMT
M
H
NAD
V
I
FA
VG
V
RF
DD
R
TTNNLAK
Y
C
P
-
NA
TV
L
HIDIDP
T
S
I
SKTVTAD
I
P
IVGD
ARQV
L
EQ
M
L
EL
L
SQESAHQ
PL
D
EI
RD
W
W
Q
QIEQW
R
ARQCLKYD--THS
E
----------------------------
K
-
IKPQAVIET
L
WR
----
LTNGDAYV
T
S
DVG
QH
QM
F
AA
LY
-
YPFDK
PR
RW
I
N
S
G
--------
GL
G
T
MG
F
GLP
A
A
L
G
V
KM
A
L
P
EET
VVC
VT
GDG
SIQ
M
NIQ
E
LS
T
AL
Q
YE
LPV
L
V
V
NL
NN
RY
LG
M
V
K
-
QWQD
M
IYSGRHSQSYMQSL
-----------
PD
F
VR
LA
E
A
Y
G
HV
G
IQ
I
SHPQ
E
LES
K
L
SEALEQ
VRN
NR
L
VF
V
D
V
T
V
D
GS
--------
E
HVY
P
M
Q
IR
G
G
G
M
D
EMWLSKTERT
fig|431946.3.peg.87
Escherichia coli SE15
MV
V
RS
L
IDQ
GV
KQ
V
F
G
YP
G
GA
V
LD
I
Y
D
A
L
HTV
-
G
G
I
D
H
V
LV
RHEQ
A
A
VHM
A
D
G
L
A
RAT
G
E
V
GV
--
V
LVT
SGPG
A
TN
A
ITG
I
A
T
A
YM
D
SI
PL
V
V
L
SG
QVATSL
IG
--
Y
D
A
FQE
C
D
MV
--------
GISRPVV
K
HSF
LV
KQT
ED
I
P
QV
L
KK
A
FWL
A
A
S
-
GRPG
P
V
V
VDLP
K
D
I
LNPANKLP
YVW
PESVSMRSYNPT-
-
-TSGHKGQ
I
KR
A
LQT
L
VA
A
KK
P
V
V
YV
G
G
G
AIT
A
G
C
HLQ
L
K
E
AVEVLNL
P
VVSS
L
M
GLG
AF
P
AT
H
R
QAL
GM
L
GM
H
G
TYEANMT
M
H
NAD
V
I
FA
VG
V
RF
DD
R
TTNNLAK
Y
C
P
-
NA
TV
L
HIDIDP
T
S
I
SKTVTAD
I
P
IVGD
ARQV
L
EQ
M
L
EL
L
SQESAHQ
PL
D
EI
RD
W
W
Q
QIEQW
R
ARQCLKYD--THS
E
----------------------------
K
-
IKPQAVIET
L
WR
----
LTNGDAYV
T
S
DVG
QH
QM
F
AA
LY
-
YPFDK
PR
RW
I
N
S
G
--------
GL
G
T
MG
F
GLP
A
A
L
G
V
KM
A
L
P
EET
VVC
VT
GDG
SIQ
M
NIQ
E
LS
T
AL
Q
YE
LPV
L
V
V
NL
NN
RY
LG
M
V
K
-
QWQD
M
IYSGRHSQSYMQSL
-----------
PD
F
VR
LA
E
A
Y
G
HV
G
IQ
I
SHPQ
E
LES
K
L
SEALEQ
VRN
NR
L
VF
V
D
V
T
V
D
GS
--------
E
HVY
P
M
Q
IR
G
G
G
M
D
EMWLSKTERT
fig|656440.3.peg.5138
Escherichia coli TA206
MV
V
RS
L
IDQ
GV
KQ
V
F
G
YP
G
GA
V
LD
I
Y
D
A
L
HTV
-
G
G
I
D
H
V
LV
RHEQ
A
A
VHM
A
D
G
L
A
RAT
G
E
V
GV
--
V
LVT
SGPG
A
TN
A
ITG
I
A
T
A
YM
D
SI
PL
V
V
L
SG
QVATSL
IG
--
Y
D
A
FQE
C
D
MV
--------
GISRPVV
K
HSF
LV
KQT
ED
I
P
QV
L
KK
A
FWL
A
A
S
-
GRPG
P
V
V
VDLP
K
D
I
LNPANKLP
YVW
PESVSMRSYNPT-
-
-TSGHKGQ
I
KR
A
LQT
L
VA
A
KK
P
V
V
YV
G
G
G
AIT
A
G
C
HLQ
L
K
E
AVEVLNL
P
VVSS
L
M
GLG
AF
P
AT
H
R
QAL
GM
L
GM
H
G
TYEANMT
M
H
NAD
V
I
FA
VG
V
RF
DD
R
TTNNLAK
Y
C
P
-
NA
TV
L
HIDIDP
T
S
I
SKTVTAD
I
P
IVGD
ARQV
L
EQ
M
L
EL
L
SQESAHQ
PL
D
EI
RD
W
W
Q
QIEQW
R
ARQCLKYD--THS
E
----------------------------
K
-
IKPQAVIET
L
WR
----
LTNGDAYV
T
S
DVG
QH
QM
F
AA
LY
-
YPFDK
PR
RW
I
N
S
G
--------
GL
G
T
MG
F
GLP
A
A
L
G
V
KM
A
L
P
EET
VVC
VT
GDG
SIQ
M
NIQ
E
LS
T
AL
Q
YE
LPV
L
V
V
NL
NN
RY
LG
M
V
K
-
QWQD
M
IYSGRHSQSYMQSL
-----------
PD
F
VR
LA
E
A
Y
G
HV
G
IQ
I
SHPQ
E
LES
K
L
SEALEQ
VRN
NR
L
VF
V
D
V
T
V
D
GS
--------
E
HVY
P
M
Q
IR
G
G
G
M
D
EMWLSKTERT
fig|562.376.peg.1230
Escherichia coli WV_060327 (9-574/574)
MV
V
RS
L
IDQ
GV
KQ
V
F
G
YP
G
GA
V
LD
I
Y
D
A
L
HTV
-
G
G
I
D
H
V
LV
RHEQ
A
A
VHM
A
D
G
L
A
RAT
G
E
V
GV
--
V
LVT
SGPG
A
TN
A
ITG
I
A
T
A
YM
D
SI
PL
V
V
L
SG
QVATSL
IG
--
Y
D
A
FQE
C
D
MV
--------
GISRPVV
K
HSF
LV
KQT
ED
I
P
QV
L
KK
A
FWL
A
A
S
-
GRPG
P
V
V
VDLP
K
D
I
LNPANKLP
YVW
PESVSMRSYNPT-
-
-TSGHKGQ
I
KR
A
LQT
L
VA
A
KK
P
V
V
YV
G
G
G
AIT
A
G
C
HLQ
L
K
E
AVEVLNL
P
VVSS
L
M
GLG
AF
P
AT
H
R
QAL
GM
L
GM
H
G
TYEANMT
M
H
NAD
V
I
FA
VG
V
RF
DD
R
TTNNLAK
Y
C
P
-
NA
TV
L
HIDIDP
T
S
I
SKTVTAD
I
P
IVGD
ARQV
L
EQ
M
L
EL
L
SQESAHQ
PL
D
EI
RD
W
W
Q
QIEQW
R
ARQCLKYD--THS
E
----------------------------
K
-
IKPQAVIET
L
WR
----
LTNGDAYV
T
S
DVG
QH
QM
F
AA
LY
-
YPFDK
PR
RW
I
N
S
G
--------
GL
G
T
MG
F
GLP
A
A
L
G
V
KM
A
L
P
EET
VVC
VT
GDG
SIQ
M
NIQ
E
LS
T
AL
Q
YE
LPV
L
V
V
NL
NN
RY
LG
M
V
K
-
QWQD
M
IYSGRHSQSYMQSL
-----------
PD
F
VR
LA
E
A
Y
G
HV
G
IQ
I
SHPQ
E
LES
K
L
SEALEQ
VRN
NR
L
VF
V
D
V
T
V
D
GS
--------
E
HVY
P
M
Q
IR
G
G
G
M
D
EMWLSKTERT
fig|405955.13.peg.86
Escherichia coli APEC O1
MV
V
RS
L
IDQ
GV
KQ
V
F
G
YP
G
GA
V
LD
I
Y
D
A
L
HTV
-
G
G
I
D
H
V
LV
RHEQ
A
A
VHM
A
D
G
L
A
RAT
G
E
V
GV
--
V
LVT
SGPG
A
TN
A
ITG
I
A
T
A
YM
D
SI
PL
V
V
L
SG
QVATSL
IG
--
Y
D
A
FQE
C
D
MV
--------
GISRPVV
K
HSF
LV
KQT
ED
I
P
QV
L
KK
A
FWL
A
A
S
-
GRPG
P
V
V
VDLP
K
D
I
LNPANKLP
YVW
PESVSMRSYNPT-
-
-TSGHKGQ
I
KR
A
LQT
L
VA
A
KK
P
V
V
YV
G
G
G
AIT
A
G
C
HLQ
L
K
E
AVEVLNL
P
VVSS
L
M
GLG
AF
P
AT
H
R
QAL
GM
L
GM
H
G
TYEANMT
M
H
NAD
V
I
FA
VG
V
RF
DD
R
TTNNLAK
Y
C
P
-
NA
TV
L
HIDIDP
T
S
I
SKTVTAD
I
P
IVGD
ARQV
L
EQ
M
L
EL
L
SQESAHQ
PL
D
EI
RD
W
W
Q
QIEQW
R
ARQCLKYD--THS
E
----------------------------
K
-
IKPQAVIET
L
WR
----
LTHGDAYV
T
S
DVG
QH
QM
F
AA
LY
-
YPFDK
PR
RW
I
N
S
G
--------
GL
G
T
MG
F
GLP
A
A
L
G
V
KM
A
L
P
EET
VVC
VT
GDG
SIQ
M
NIQ
E
LS
T
AL
Q
YE
LPV
L
V
V
NL
NN
RY
LG
M
V
K
-
QWQD
M
IYSGRHSQSYMQSL
-----------
PD
F
VR
LA
E
A
Y
G
HV
G
IQ
I
SHPQ
E
LES
K
L
SEALEQ
VRN
NR
L
VF
V
D
V
T
V
D
GS
--------
E
HVY
P
M
Q
IR
G
G
G
M
D
EMWLSKTERT
fig|405955.9.peg.66
Escherichia coli APEC O1 (39-604/604)
MV
V
RS
L
IDQ
GV
KQ
V
F
G
YP
G
GA
V
LD
I
Y
D
A
L
HTV
-
G
G
I
D
H
V
LV
RHEQ
A
A
VHM
A
D
G
L
A
RAT
G
E
V
GV
--
V
LVT
SGPG
A
TN
A
ITG
I
A
T
A
YM
D
SI
PL
V
V
L
SG
QVATSL
IG
--
Y
D
A
FQE
C
D
MV
--------
GISRPVV
K
HSF
LV
KQT
ED
I
P
QV
L
KK
A
FWL
A
A
S
-
GRPG
P
V
V
VDLP
K
D
I
LNPANKLP
YVW
PESVSMRSYNPT-
-
-TSGHKGQ
I
KR
A
LQT
L
VA
A
KK
P
V
V
YV
G
G
G
AIT
A
G
C
HLQ
L
K
E
AVEVLNL
P
VVSS
L
M
GLG
AF
P
AT
H
R
QAL
GM
L
GM
H
G
TYEANMT
M
H
NAD
V
I
FA
VG
V
RF
DD
R
TTNNLAK
Y
C
P
-
NA
TV
L
HIDIDP
T
S
I
SKTVTAD
I
P
IVGD
ARQV
L
EQ
M
L
EL
L
SQESAHQ
PL
D
EI
RD
W
W
Q
QIEQW
R
ARQCLKYD--THS
E
----------------------------
K
-
IKPQAVIET
L
WR
----
LTHGDAYV
T
S
DVG
QH
QM
F
AA
LY
-
YPFDK
PR
RW
I
N
S
G
--------
GL
G
T
MG
F
GLP
A
A
L
G
V
KM
A
L
P
EET
VVC
VT
GDG
SIQ
M
NIQ
E
LS
T
AL
Q
YE
LPV
L
V
V
NL
NN
RY
LG
M
V
K
-
QWQD
M
IYSGRHSQSYMQSL
-----------
PD
F
VR
LA
E
A
Y
G
HV
G
IQ
I
SHPQ
E
LES
K
L
SEALEQ
VRN
NR
L
VF
V
D
V
T
V
D
GS
--------
E
HVY
P
M
Q
IR
G
G
G
M
D
EMWLSKTERT
fig|714962.3.peg.84
Escherichia coli IHE3034
MV
V
RS
L
IDQ
GV
KQ
V
F
G
YP
G
GA
V
LD
I
Y
D
A
L
HTV
-
G
G
I
D
H
V
LV
RHEQ
A
A
VHM
A
D
G
L
A
RAT
G
E
V
GV
--
V
LVT
SGPG
A
TN
A
ITG
I
A
T
A
YM
D
SI
PL
V
V
L
SG
QVATSL
IG
--
Y
D
A
FQE
C
D
MV
--------
GISRPVV
K
HSF
LV
KQT
ED
I
P
QV
L
KK
A
FWL
A
A
S
-
GRPG
P
V
V
VDLP
K
D
I
LNPANKLP
YVW
PESVSMRSYNPT-
-
-TSGHKGQ
I
KR
A
LQT
L
VA
A
KK
P
V
V
YV
G
G
G
AIT
A
G
C
HLQ
L
K
E
AVEVLNL
P
VVSS
L
M
GLG
AF
P
AT
H
R
QAL
GM
L
GM
H
G
TYEANMT
M
H
NAD
V
I
FA
VG
V
RF
DD
R
TTNNLAK
Y
C
P
-
NA
TV
L
HIDIDP
T
S
I
SKTVTAD
I
P
IVGD
ARQV
L
EQ
M
L
EL
L
SQESAHQ
PL
D
EI
RD
W
W
Q
QIEQW
R
ARQCLKYD--THS
E
----------------------------
K
-
IKPQAVIET
L
WR
----
LTHGDAYV
T
S
DVG
QH
QM
F
AA
LY
-
YPFDK
PR
RW
I
N
S
G
--------
GL
G
T
MG
F
GLP
A
A
L
G
V
KM
A
L
P
EET
VVC
VT
GDG
SIQ
M
NIQ
E
LS
T
AL
Q
YE
LPV
L
V
V
NL
NN
RY
LG
M
V
K
-
QWQD
M
IYSGRHSQSYMQSL
-----------
PD
F
VR
LA
E
A
Y
G
HV
G
IQ
I
SHPQ
E
LES
K
L
SEALEQ
VRN
NR
L
VF
V
D
V
T
V
D
GS
--------
E
HVY
P
M
Q
IR
G
G
G
M
D
EMWLSKTERT
fig|753642.3.peg.3555
Escherichia coli NC101
MV
V
RS
L
IDQ
GV
KQ
V
F
G
YP
G
GA
V
LD
I
Y
D
A
L
HTV
-
G
G
I
D
H
V
LV
RHEQ
A
A
VHM
A
D
G
L
A
RAT
G
E
V
GV
--
V
LVT
SGPG
A
TN
A
ITG
I
A
T
A
YM
D
SI
PL
V
V
L
SG
QVATSL
IG
--
Y
D
A
FQE
C
D
MV
--------
GISRPVV
K
HSF
LV
KQT
ED
I
P
QV
L
KK
A
FWL
A
A
S
-
GRPG
P
V
V
VDLP
K
D
I
LNPANKLP
YVW
PESVSMRSYNPT-
-
-TSGHKGQ
I
KR
A
LQT
L
VA
A
KK
P
V
V
YV
G
G
G
AIT
A
G
C
HLQ
L
K
E
AVEVLNL
P
VVSS
L
M
GLG
AF
P
AT
H
R
QAL
GM
L
GM
H
G
TYEANMT
M
H
NAD
V
I
FA
VG
V
RF
DD
R
TTNNLAK
Y
C
P
-
NA
TV
L
HIDIDP
T
S
I
SKTVTAD
I
P
IVGD
ARQV
L
EQ
M
L
EL
L
SQESAHQ
PL
D
EI
RD
W
W
Q
QIEQW
R
ARQCLKYD--THS
E
----------------------------
K
-
IKPQAVIET
L
WR
----
LTHGDAYV
T
S
DVG
QH
QM
F
AA
LY
-
YPFDK
PR
RW
I
N
S
G
--------
GL
G
T
MG
F
GLP
A
A
L
G
V
KM
A
L
P
EET
VVC
VT
GDG
SIQ
M
NIQ
E
LS
T
AL
Q
YE
LPV
L
V
V
NL
NN
RY
LG
M
V
K
-
QWQD
M
IYSGRHSQSYMQSL
-----------
PD
F
VR
LA
E
A
Y
G
HV
G
IQ
I
SHPQ
E
LES
K
L
SEALEQ
VRN
NR
L
VF
V
D
V
T
V
D
GS
--------
E
HVY
P
M
Q
IR
G
G
G
M
D
EMWLSKTERT
fig|685038.3.peg.79
Escherichia coli O83:H1 str. NRG 857C
MV
V
RS
L
IDQ
GV
KQ
V
F
G
YP
G
GA
V
LD
I
Y
D
A
L
HTV
-
G
G
I
D
H
V
LV
RHEQ
A
A
VHM
A
D
G
L
A
RAT
G
E
V
GV
--
V
LVT
SGPG
A
TN
A
ITG
I
A
T
A
YM
D
SI
PL
V
V
L
SG
QVATSL
IG
--
Y
D
A
FQE
C
D
MV
--------
GISRPVV
K
HSF
LV
KQT
ED
I
P
QV
L
KK
A
FWL
A
A
S
-
GRPG
P
V
V
VDLP
K
D
I
LNPANKLP
YVW
PESVSMRSYNPT-
-
-TSGHKGQ
I
KR
A
LQT
L
VA
A
KK
P
V
V
YV
G
G
G
AIT
A
G
C
HLQ
L
K
E
AVEVLNL
P
VVSS
L
M
GLG
AF
P
AT
H
R
QAL
GM
L
GM
H
G
TYEANMT
M
H
NAD
V
I
FA
VG
V
RF
DD
R
TTNNLAK
Y
C
P
-
NA
TV
L
HIDIDP
T
S
I
SKTVTAD
I
P
IVGD
ARQV
L
EQ
M
L
EL
L
SQESAHQ
PL
D
EI
RD
W
W
Q
QIEQW
R
ARQCLKYD--THS
E
----------------------------
K
-
IKPQAVIET
L
WR
----
LTHGDAYV
T
S
DVG
QH
QM
F
AA
LY
-
YPFDK
PR
RW
I
N
S
G
--------
GL
G
T
MG
F
GLP
A
A
L
G
V
KM
A
L
P
EET
VVC
VT
GDG
SIQ
M
NIQ
E
LS
T
AL
Q
YE
LPV
L
V
V
NL
NN
RY
LG
M
V
K
-
QWQD
M
IYSGRHSQSYMQSL
-----------
PD
F
VR
LA
E
A
Y
G
HV
G
IQ
I
SHPQ
E
LES
K
L
SEALEQ
VRN
NR
L
VF
V
D
V
T
V
D
GS
--------
E
HVY
P
M
Q
IR
G
G
G
M
D
EMWLSKTERT
fig|585035.6.peg.88
Escherichia coli S88
MV
V
RS
L
IDQ
GV
KQ
V
F
G
YP
G
GA
V
LD
I
Y
D
A
L
HTV
-
G
G
I
D
H
V
LV
RHEQ
A
A
VHM
A
D
G
L
A
RAT
G
E
V
GV
--
V
LVT
SGPG
A
TN
A
ITG
I
A
T
A
YM
D
SI
PL
V
V
L
SG
QVATSL
IG
--
Y
D
A
FQE
C
D
MV
--------
GISRPVV
K
HSF
LV
KQT
ED
I
P
QV
L
KK
A
FWL
A
A
S
-
GRPG
P
V
V
VDLP
K
D
I
LNPANKLP
YVW
PESVSMRSYNPT-
-
-TSGHKGQ
I
KR
A
LQT
L
VA
A
KK
P
V
V
YV
G
G
G
AIT
A
G
C
HLQ
L
K
E
AVEVLNL
P
VVSS
L
M
GLG
AF
P
AT
H
R
QAL
GM
L
GM
H
G
TYEANMT
M
H
NAD
V
I
FA
VG
V
RF
DD
R
TTNNLAK
Y
C
P
-
NA
TV
L
HIDIDP
T
S
I
SKTVTAD
I
P
IVGD
ARQV
L
EQ
M
L
EL
L
SQESAHQ
PL
D
EI
RD
W
W
Q
QIEQW
R
ARQCLKYD--THS
E
----------------------------
K
-
IKPQAVIET
L
WR
----
LTHGDAYV
T
S
DVG
QH
QM
F
AA
LY
-
YPFDK
PR
RW
I
N
S
G
--------
GL
G
T
MG
F
GLP
A
A
L
G
V
KM
A
L
P
EET
VVC
VT
GDG
SIQ
M
NIQ
E
LS
T
AL
Q
YE
LPV
L
V
V
NL
NN
RY
LG
M
V
K
-
QWQD
M
IYSGRHSQSYMQSL
-----------
PD
F
VR
LA
E
A
Y
G
HV
G
IQ
I
SHPQ
E
LES
K
L
SEALEQ
VRN
NR
L
VF
V
D
V
T
V
D
GS
--------
E
HVY
P
M
Q
IR
G
G
G
M
D
EMWLSKTERT
fig|869729.3.peg.4986
Escherichia coli UM146 (9-574/574)
MV
V
RS
L
IDQ
GV
KQ
V
F
G
YP
G
GA
V
LD
I
Y
D
A
L
HTV
-
G
G
I
D
H
V
LV
RHEQ
A
A
VHM
A
D
G
L
A
RAT
G
E
V
GV
--
V
LVT
SGPG
A
TN
A
ITG
I
A
T
A
YM
D
SI
PL
V
V
L
SG
QVATSL
IG
--
Y
D
A
FQE
C
D
MV
--------
GISRPVV
K
HSF
LV
KQT
ED
I
P
QV
L
KK
A
FWL
A
A
S
-
GRPG
P
V
V
VDLP
K
D
I
LNPANKLP
YVW
PESVSMRSYNPT-
-
-TSGHKGQ
I
KR
A
LQT
L
VA
A
KK
P
V
V
YV
G
G
G
AIT
A
G
C
HLQ
L
K
E
AVEVLNL
P
VVSS
L
M
GLG
AF
P
AT
H
R
QAL
GM
L
GM
H
G
TYEANMT
M
H
NAD
V
I
FA
VG
V
RF
DD
R
TTNNLAK
Y
C
P
-
NA
TV
L
HIDIDP
T
S
I
SKTVTAD
I
P
IVGD
ARQV
L
EQ
M
L
EL
L
SQESAHQ
PL
D
EI
RD
W
W
Q
QIEQW
R
ARQCLKYD--THS
E
----------------------------
K
-
IKPQAVIET
L
WR
----
LTHGDAYV
T
S
DVG
QH
QM
F
AA
LY
-
YPFDK
PR
RW
I
N
S
G
--------
GL
G
T
MG
F
GLP
A
A
L
G
V
KM
A
L
P
EET
VVC
VT
GDG
SIQ
M
NIQ
E
LS
T
AL
Q
YE
LPV
L
V
V
NL
NN
RY
LG
M
V
K
-
QWQD
M
IYSGRHSQSYMQSL
-----------
PD
F
VR
LA
E
A
Y
G
HV
G
IQ
I
SHPQ
E
LES
K
L
SEALEQ
VRN
NR
L
VF
V
D
V
T
V
D
GS
--------
E
HVY
P
M
Q
IR
G
G
G
M
D
EMWLSKTERT
fig|364106.7.peg.217
Escherichia coli UTI89 (9-574/574)
MV
V
RS
L
IDQ
GV
KQ
V
F
G
YP
G
GA
V
LD
I
Y
D
A
L
HTV
-
G
G
I
D
H
V
LV
RHEQ
A
A
VHM
A
D
G
L
A
RAT
G
E
V
GV
--
V
LVT
SGPG
A
TN
A
ITG
I
A
T
A
YM
D
SI
PL
V
V
L
SG
QVATSL
IG
--
Y
D
A
FQE
C
D
MV
--------
GISRPVV
K
HSF
LV
KQT
ED
I
P
QV
L
KK
A
FWL
A
A
S
-
GRPG
P
V
V
VDLP
K
D
I
LNPANKLP
YVW
PESVSMRSYNPT-
-
-TSGHKGQ
I
KR
A
LQT
L
VA
A
KK
P
V
V
YV
G
G
G
AIT
A
G
C
HLQ
L
K
E
AVEVLNL
P
VVSS
L
M
GLG
AF
P
AT
H
R
QAL
GM
L
GM
H
G
TYEANMT
M
H
NAD
V
I
FA
VG
V
RF
DD
R
TTNNLAK
Y
C
P
-
NA
TV
L
HIDIDP
T
S
I
SKTVTAD
I
P
IVGD
ARQV
L
EQ
M
L
EL
L
SQESAHQ
PL
D
EI
RD
W
W
Q
QIEQW
R
ARQCLKYD--THS
E
----------------------------
K
-
IKPQAVIET
L
WR
----
LTHGDAYV
T
S
DVG
QH
QM
F
AA
LY
-
YPFDK
PR
RW
I
N
S
G
--------
GL
G
T
MG
F
GLP
A
A
L
G
V
KM
A
L
P
EET
VVC
VT
GDG
SIQ
M
NIQ
E
LS
T
AL
Q
YE
LPV
L
V
V
NL
NN
RY
LG
M
V
K
-
QWQD
M
IYSGRHSQSYMQSL
-----------
PD
F
VR
LA
E
A
Y
G
HV
G
IQ
I
SHPQ
E
LES
K
L
SEALEQ
VRN
NR
L
VF
V
D
V
T
V
D
GS
--------
E
HVY
P
M
Q
IR
G
G
G
M
D
EMWLSKTERT
fig|364106.8.peg.216
Escherichia coli UTI89 (9-574/574)
MV
V
RS
L
IDQ
GV
KQ
V
F
G
YP
G
GA
V
LD
I
Y
D
A
L
HTV
-
G
G
I
D
H
V
LV
RHEQ
A
A
VHM
A
D
G
L
A
RAT
G
E
V
GV
--
V
LVT
SGPG
A
TN
A
ITG
I
A
T
A
YM
D
SI
PL
V
V
L
SG
QVATSL
IG
--
Y
D
A
FQE
C
D
MV
--------
GISRPVV
K
HSF
LV
KQT
ED
I
P
QV
L
KK
A
FWL
A
A
S
-
GRPG
P
V
V
VDLP
K
D
I
LNPANKLP
YVW
PESVSMRSYNPT-
-
-TSGHKGQ
I
KR
A
LQT
L
VA
A
KK
P
V
V
YV
G
G
G
AIT
A
G
C
HLQ
L
K
E
AVEVLNL
P
VVSS
L
M
GLG
AF
P
AT
H
R
QAL
GM
L
GM
H
G
TYEANMT
M
H
NAD
V
I
FA
VG
V
RF
DD
R
TTNNLAK
Y
C
P
-
NA
TV
L
HIDIDP
T
S
I
SKTVTAD
I
P
IVGD
ARQV
L
EQ
M
L
EL
L
SQESAHQ
PL
D
EI
RD
W
W
Q
QIEQW
R
ARQCLKYD--THS
E
----------------------------
K
-
IKPQAVIET
L
WR
----
LTHGDAYV
T
S
DVG
QH
QM
F
AA
LY
-
YPFDK
PR
RW
I
N
S
G
--------
GL
G
T
MG
F
GLP
A
A
L
G
V
KM
A
L
P
EET
VVC
VT
GDG
SIQ
M
NIQ
E
LS
T
AL
Q
YE
LPV
L
V
V
NL
NN
RY
LG
M
V
K
-
QWQD
M
IYSGRHSQSYMQSL
-----------
PD
F
VR
LA
E
A
Y
G
HV
G
IQ
I
SHPQ
E
LES
K
L
SEALEQ
VRN
NR
L
VF
V
D
V
T
V
D
GS
--------
E
HVY
P
M
Q
IR
G
G
G
M
D
EMWLSKTERT
fig|362663.8.peg.3989
Escherichia coli 536 (7-543/548)
V
V
HA
L
RAQ
GV
NT
V
F
G
YP
G
GA
I
MP
V
Y
D
A
L
YDG
-
G
-
V
E
H
L
LC
RHEQ
G
A
AMA
A
I
G
Y
A
RAT
GK
T
GV
--
C
IAT
SGPG
A
TN
L
ITGLA
D
A
LL
D
SI
P
VV
A
I
T
G
QVSAPF
IG
--
T
D
A
FQE
V
D
IL
--------
GLSLACT
K
HSF
LV
QSL
E
E
LP
RI
M
AE
A
FDV
A
S
S
-
GRPG
P
V
L
VD
I
P
K
D
I
QLASGDLE
---
PWFTTVENEV---
-
-TFSHA-E
V
EQ
A
RQM
L
AK
A
QK
P
M
L
YV
G
G
G
VGM
A
Q
A
VSA
L
R
E
FLAATKM
P
ATCT
L
K
GLG
AV
E
AD
Y
P
YYL
GM
L
GM
H
G
TKAANFA
V
Q
EC
D
L
L
IA
VG
A
RF
DD
R
VTGKLNT
F
A
P
-
H
A
SV
IH
M
DIDP
A
E
M
NKLRQAH
VA
L
Q
GD
----
L
NA
LL
PA
L
Q-----Q
PL
N
-
I
DD
W
Q
Q
HCAQL
R
DEHAWRYD--HPG
D
----------------------------
A
-
IYAPLLLKQ
L
SD
----
RKSADCIV
T
T
DVG
QH
QM
W
AA
QH
-
IVHTR
P
E
NF
I
T
S
S
--------
GL
G
T
MG
F
GLP
A
A
V
GA
QV
A
R
P
NDT
VVC
IS
GDG
SFM
M
NVQ
E
LG
T
VK
R
KQ
LP
L
K
IV
LL
D
N
QR
LG
M
V
R
-
QWQQ
L
FFQERYSETTLTDN
-----------
PD
F
LM
LA
S
A
F
G
IP
G
QH
I
THKD
Q
VEA
AL
DTMLNS
---
DG
P
YL
L
HV
S
ID
EL
--------
E
NVW
P
L
V
PP
GA
S
N
S
EM
fig|362663.9.peg.4005
Escherichia coli 536 (7-543/548)
V
V
HA
L
RAQ
GV
NT
V
F
G
YP
G
GA
I
MP
V
Y
D
A
L
YDG
-
G
-
V
E
H
L
LC
RHEQ
G
A
AMA
A
I
G
Y
A
RAT
GK
T
GV
--
C
IAT
SGPG
A
TN
L
ITGLA
D
A
LL
D
SI
P
VV
A
I
T
G
QVSAPF
IG
--
T
D
A
FQE
V
D
IL
--------
GLSLACT
K
HSF
LV
QSL
E
E
LP
RI
M
AE
A
FDV
A
S
S
-
GRPG
P
V
L
VD
I
P
K
D
I
QLASGDLE
---
PWFTTVENEV---
-
-TFSHA-E
V
EQ
A
RQM
L
AK
A
QK
P
M
L
YV
G
G
G
VGM
A
Q
A
VSA
L
R
E
FLAATKM
P
ATCT
L
K
GLG
AV
E
AD
Y
P
YYL
GM
L
GM
H
G
TKAANFA
V
Q
EC
D
L
L
IA
VG
A
RF
DD
R
VTGKLNT
F
A
P
-
H
A
SV
IH
M
DIDP
A
E
M
NKLRQAH
VA
L
Q
GD
----
L
NA
LL
PA
L
Q-----Q
PL
N
-
I
DD
W
Q
Q
HCAQL
R
DEHAWRYD--HPG
D
----------------------------
A
-
IYAPLLLKQ
L
SD
----
RKSADCIV
T
T
DVG
QH
QM
W
AA
QH
-
IVHTR
P
E
NF
I
T
S
S
--------
GL
G
T
MG
F
GLP
A
A
V
GA
QV
A
R
P
NDT
VVC
IS
GDG
SFM
M
NVQ
E
LG
T
VK
R
KQ
LP
L
K
IV
LL
D
N
QR
LG
M
V
R
-
QWQQ
L
FFQERYSETTLTDN
-----------
PD
F
LM
LA
S
A
F
G
IP
G
QH
I
THKD
Q
VEA
AL
DTMLNS
---
DG
P
YL
L
HV
S
ID
EL
--------
E
NVW
P
L
V
PP
GA
S
N
S
EM
fig|405955.9.peg.3533
Escherichia coli APEC O1 (7-543/548)
V
V
HA
L
RAQ
GV
NT
V
F
G
YP
G
GA
I
MP
V
Y
D
A
L
YDG
-
G
-
V
E
H
L
LC
RHEQ
G
A
AMA
A
I
G
Y
A
RAT
GK
T
GV
--
C
IAT
SGPG
A
TN
L
ITGLA
D
A
LL
D
SI
P
VV
A
I
T
G
QVSAPF
IG
--
T
D
A
FQE
V
D
IL
--------
GLSLACT
K
HSF
LV
QSL
E
E
LP
RI
M
AE
A
FDV
A
S
S
-
GRPG
P
V
L
VD
I
P
K
D
I
QLASGDLE
---
PWFTTVENEV---
-
-TFSHA-E
V
EQ
A
RQM
L
AK
A
QK
P
M
L
YV
G
G
G
VGM
A
Q
A
VSA
L
R
E
FLAATKM
P
ATCT
L
K
GLG
AV
E
AD
Y
P
YYL
GM
L
GM
H
G
TKAANFA
V
Q
EC
D
L
L
IA
VG
A
RF
DD
R
VTGKLNT
F
A
P
-
H
A
SV
IH
M
DIDP
A
E
M
NKLRQAH
VA
L
Q
GD
----
L
NA
LL
PA
L
Q-----Q
PL
N
-
I
DD
W
Q
Q
HCAQL
R
DEHAWRYD--HPG
D
----------------------------
A
-
IYAPLLLKQ
L
SD
----
RKSADCIV
T
T
DVG
QH
QM
W
AA
QH
-
IVHTR
P
E
NF
I
T
S
S
--------
GL
G
T
MG
F
GLP
A
A
V
GA
QV
A
R
P
NDT
VVC
IS
GDG
SFM
M
NVQ
E
LG
T
VK
R
KQ
LP
L
K
IV
LL
D
N
QR
LG
M
V
R
-
QWQQ
L
FFQERYSETTLTDN
-----------
PD
F
LM
LA
S
A
F
G
IP
G
QH
I
THKD
Q
VEA
AL
DTMLNS
---
DG
P
YL
L
HV
S
ID
EL
--------
E
NVW
P
L
V
PP
GA
S
N
S
EM
fig|585397.9.peg.4443
Escherichia coli ED1a (7-543/548)
V
V
HA
L
RAQ
GV
NT
V
F
G
YP
G
GA
I
MP
V
Y
D
A
L
YDG
-
G
-
V
E
H
L
LC
RHEQ
G
A
AMA
A
I
G
Y
A
RAT
GK
T
GV
--
C
IAT
SGPG
A
TN
L
ITGLA
D
A
LL
D
SI
P
VV
A
I
T
G
QVSAPF
IG
--
T
D
A
FQE
V
D
IL
--------
GLSLACT
K
HSF
LV
QSL
E
E
LP
RI
M
AE
A
FDV
A
S
S
-
GRPG
P
V
L
VD
I
P
K
D
I
QLASGDLE
---
PWFTTVENEV---
-
-TFSHA-E
V
EQ
A
RQM
L
AK
A
QK
P
M
L
YV
G
G
G
VGM
A
Q
A
VSA
L
R
E
FLAATKM
P
ATCT
L
K
GLG
AV
E
AD
Y
P
YYL
GM
L
GM
H
G
TKAANFA
V
Q
EC
D
L
L
IA
VG
A
RF
DD
R
VTGKLNT
F
A
P
-
H
A
SV
IH
M
DIDP
A
E
M
NKLRQAH
VA
L
Q
GD
----
L
NA
LL
PA
L
Q-----Q
PL
N
-
I
DD
W
Q
Q
HCAQL
R
DEHAWRYD--HPG
D
----------------------------
A
-
IYAPLLLKQ
L
SD
----
RKSADCIV
T
T
DVG
QH
QM
W
AA
QH
-
IVHTR
P
E
NF
I
T
S
S
--------
GL
G
T
MG
F
GLP
A
A
V
GA
QV
A
R
P
NDT
VVC
IS
GDG
SFM
M
NVQ
E
LG
T
VK
R
KQ
LP
L
K
IV
LL
D
N
QR
LG
M
V
R
-
QWQQ
L
FFQERYSETTLTDN
-----------
PD
F
LM
LA
S
A
F
G
IP
G
QH
I
THKD
Q
VEA
AL
DTMLNS
---
DG
P
YL
L
HV
S
ID
EL
--------
E
NVW
P
L
V
PP
GA
S
N
S
EM
fig|340197.3.peg.4488
Escherichia coli F11 (7-543/548)
V
V
HA
L
RAQ
GV
NT
V
F
G
YP
G
GA
I
MP
V
Y
D
A
L
YDG
-
G
-
V
E
H
L
LC
RHEQ
G
A
AMA
A
I
G
Y
A
RAT
GK
T
GV
--
C
IAT
SGPG
A
TN
L
ITGLA
D
A
LL
D
SI
P
VV
A
I
T
G
QVSAPF
IG
--
T
D
A
FQE
V
D
IL
--------
GLSLACT
K
HSF
LV
QSL
E
E
LP
RI
M
AE
A
FDV
A
S
S
-
GRPG
P
V
L
VD
I
P
K
D
I
QLASGDLE
---
PWFTTVENEV---
-
-TFSHA-E
V
EQ
A
RQM
L
AK
A
QK
P
M
L
YV
G
G
G
VGM
A
Q
A
VSA
L
R
E
FLAATKM
P
ATCT
L
K
GLG
AV
E
AD
Y
P
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GM
L
GM
H
G
TKAANFA
V
Q
EC
D
L
L
IA
VG
A
RF
DD
R
VTGKLNT
F
A
P
-
H
A
SV
IH
M
DIDP
A
E
M
NKLRQAH
VA
L
Q
GD
----
L
NA
LL
PA
L
Q-----Q
PL
N
-
I
DD
W
Q
Q
HCAQL
R
DEHAWRYD--HPG
D
----------------------------
A
-
IYAPLLLKQ
L
SD
----
RKSADCIV
T
T
DVG
QH
QM
W
AA
QH
-
IVHTR
P
E
NF
I
T
S
S
--------
GL
G
T
MG
F
GLP
A
A
V
GA
QV
A
R
P
NDT
VVC
IS
GDG
SFM
M
NVQ
E
LG
T
VK
R
KQ
LP
L
K
IV
LL
D
N
QR
LG
M
V
R
-
QWQQ
L
FFQERYSETTLTDN
-----------
PD
F
LM
LA
S
A
F
G
IP
G
QH
I
THKD
Q
VEA
AL
DTMLNS
---
DG
P
YL
L
HV
S
ID
EL
--------
E
NVW
P
L
V
PP
GA
S
N
S
EM
fig|340197.5.peg.4693
Escherichia coli F11 (7-543/548)
V
V
HA
L
RAQ
GV
NT
V
F
G
YP
G
GA
I
MP
V
Y
D
A
L
YDG
-
G
-
V
E
H
L
LC
RHEQ
G
A
AMA
A
I
G
Y
A
RAT
GK
T
GV
--
C
IAT
SGPG
A
TN
L
ITGLA
D
A
LL
D
SI
P
VV
A
I
T
G
QVSAPF
IG
--
T
D
A
FQE
V
D
IL
--------
GLSLACT
K
HSF
LV
QSL
E
E
LP
RI
M
AE
A
FDV
A
S
S
-
GRPG
P
V
L
VD
I
P
K
D
I
QLASGDLE
---
PWFTTVENEV---
-
-TFSHA-E
V
EQ
A
RQM
L
AK
A
QK
P
M
L
YV
G
G
G
VGM
A
Q
A
VSA
L
R
E
FLAATKM
P
ATCT
L
K
GLG
AV
E
AD
Y
P
YYL
GM
L
GM
H
G
TKAANFA
V
Q
EC
D
L
L
IA
VG
A
RF
DD
R
VTGKLNT
F
A
P
-
H
A
SV
IH
M
DIDP
A
E
M
NKLRQAH
VA
L
Q
GD
----
L
NA
LL
PA
L
Q-----Q
PL
N
-
I
DD
W
Q
Q
HCAQL
R
DEHAWRYD--HPG
D
----------------------------
A
-
IYAPLLLKQ
L
SD
----
RKSADCIV
T
T
DVG
QH
QM
W
AA
QH
-
IVHTR
P
E
NF
I
T
S
S
--------
GL
G
T
MG
F
GLP
A
A
V
GA
QV
A
R
P
NDT
VVC
IS
GDG
SFM
M
NVQ
E
LG
T
VK
R
KQ
LP
L
K
IV
LL
D
N
QR
LG
M
V
R
-
QWQQ
L
FFQERYSETTLTDN
-----------
PD
F
LM
LA
S
A
F
G
IP
G
QH
I
THKD
Q
VEA
AL
DTMLNS
---
DG
P
YL
L
HV
S
ID
EL
--------
E
NVW
P
L
V
PP
GA
S
N
S
EM
fig|714962.3.peg.4253
Escherichia coli IHE3034 (7-543/548)
V
V
HA
L
RAQ
GV
NT
V
F
G
YP
G
GA
I
MP
V
Y
D
A
L
YDG
-
G
-
V
E
H
L
LC
RHEQ
G
A
AMA
A
I
G
Y
A
RAT
GK
T
GV
--
C
IAT
SGPG
A
TN
L
ITGLA
D
A
LL
D
SI
P
VV
A
I
T
G
QVSAPF
IG
--
T
D
A
FQE
V
D
IL
--------
GLSLACT
K
HSF
LV
QSL
E
E
LP
RI
M
AE
A
FDV
A
S
S
-
GRPG
P
V
L
VD
I
P
K
D
I
QLASGDLE
---
PWFTTVENEV---
-
-TFSHA-E
V
EQ
A
RQM
L
AK
A
QK
P
M
L
YV
G
G
G
VGM
A
Q
A
VSA
L
R
E
FLAATKM
P
ATCT
L
K
GLG
AV
E
AD
Y
P
YYL
GM
L
GM
H
G
TKAANFA
V
Q
EC
D
L
L
IA
VG
A
RF
DD
R
VTGKLNT
F
A
P
-
H
A
SV
IH
M
DIDP
A
E
M
NKLRQAH
VA
L
Q
GD
----
L
NA
LL
PA
L
Q-----Q
PL
N
-
I
DD
W
Q
Q
HCAQL
R
DEHAWRYD--HPG
D
----------------------------
A
-
IYAPLLLKQ
L
SD
----
RKSADCIV
T
T
DVG
QH
QM
W
AA
QH
-
IVHTR
P
E
NF
I
T
S
S
--------
GL
G
T
MG
F
GLP
A
A
V
GA
QV
A
R
P
NDT
VVC
IS
GDG
SFM
M
NVQ
E
LG
T
VK
R
KQ
LP
L
K
IV
LL
D
N
QR
LG
M
V
R
-
QWQQ
L
FFQERYSETTLTDN
-----------
PD
F
LM
LA
S
A
F
G
IP
G
QH
I
THKD
Q
VEA
AL
DTMLNS
---
DG
P
YL
L
HV
S
ID
EL
--------
E
NVW
P
L
V
PP
GA
S
N
S
EM
fig|749550.3.peg.1183
Escherichia coli MS 200-1 (7-543/548)
V
V
HA
L
RAQ
GV
NT
V
F
G
YP
G
GA
I
MP
V
Y
D
A
L
YDG
-
G
-
V
E
H
L
LC
RHEQ
G
A
AMA
A
I
G
Y
A
RAT
GK
T
GV
--
C
IAT
SGPG
A
TN
L
ITGLA
D
A
LL
D
SI
P
VV
A
I
T
G
QVSAPF
IG
--
T
D
A
FQE
V
D
IL
--------
GLSLACT
K
HSF
LV
QSL
E
E
LP
RI
M
AE
A
FDV
A
S
S
-
GRPG
P
V
L
VD
I
P
K
D
I
QLASGDLE
---
PWFTTVENEV---
-
-TFSHA-E
V
EQ
A
RQM
L
AK
A
QK
P
M
L
YV
G
G
G
VGM
A
Q
A
VSA
L
R
E
FLAATKM
P
ATCT
L
K
GLG
AV
E
AD
Y
P
YYL
GM
L
GM
H
G
TKAANFA
V
Q
EC
D
L
L
IA
VG
A
RF
DD
R
VTGKLNT
F
A
P
-
H
A
SV
IH
M
DIDP
A
E
M
NKLRQAH
VA
L
Q
GD
----
L
NA
LL
PA
L
Q-----Q
PL
N
-
I
DD
W
Q
Q
HCAQL
R
DEHAWRYD--HPG
D
----------------------------
A
-
IYAPLLLKQ
L
SD
----
RKSADCIV
T
T
DVG
QH
QM
W
AA
QH
-
IVHTR
P
E
NF
I
T
S
S
--------
GL
G
T
MG
F
GLP
A
A
V
GA
QV
A
R
P
NDT
VVC
IS
GDG
SFM
M
NVQ
E
LG
T
VK
R
KQ
LP
L
K
IV
LL
D
N
QR
LG
M
V
R
-
QWQQ
L
FFQERYSETTLTDN
-----------
PD
F
LM
LA
S
A
F
G
IP
G
QH
I
THKD
Q
VEA
AL
DTMLNS
---
DG
P
YL
L
HV
S
ID
EL
--------
E
NVW
P
L
V
PP
GA
S
N
S
EM
fig|869729.3.peg.4073
Escherichia coli UM146 (7-543/548)
V
V
HA
L
RAQ
GV
NT
V
F
G
YP
G
GA
I
MP
V
Y
D
A
L
YDG
-
G
-
V
E
H
L
LC
RHEQ
G
A
AMA
A
I
G
Y
A
RAT
GK
T
GV
--
C
IAT
SGPG
A
TN
L
ITGLA
D
A
LL
D
SI
P
VV
A
I
T
G
QVSAPF
IG
--
T
D
A
FQE
V
D
IL
--------
GLSLACT
K
HSF
LV
QSL
E
E
LP
RI
M
AE
A
FDV
A
S
S
-
GRPG
P
V
L
VD
I
P
K
D
I
QLASGDLE
---
PWFTTVENEV---
-
-TFSHA-E
V
EQ
A
RQM
L
AK
A
QK
P
M
L
YV
G
G
G
VGM
A
Q
A
VSA
L
R
E
FLAATKM
P
ATCT
L
K
GLG
AV
E
AD
Y
P
YYL
GM
L
GM
H
G
TKAANFA
V
Q
EC
D
L
L
IA
VG
A
RF
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R
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F
A
P
-
H
A
SV
IH
M
DIDP
A
E
M
NKLRQAH
VA
L
Q
GD
----
L
NA
LL
PA
L
Q-----Q
PL
N
-
I
DD
W
Q
Q
HCAQL
R
DEHAWRYD--HPG
D
----------------------------
A
-
IYAPLLLKQ
L
SD
----
RKSADCIV
T
T
DVG
QH
QM
W
AA
QH
-
IVHTR
P
E
NF
I
T
S
S
--------
GL
G
T
MG
F
GLP
A
A
V
GA
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A
R
P
NDT
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IS
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M
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E
LG
T
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R
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LP
L
K
IV
LL
D
N
QR
LG
M
V
R
-
QWQQ
L
FFQERYSETTLTDN
-----------
PD
F
LM
LA
S
A
F
G
IP
G
QH
I
THKD
Q
VEA
AL
DTMLNS
---
DG
P
YL
L
HV
S
ID
EL
--------
E
NVW
P
L
V
PP
GA
S
N
S
EM
fig|364106.7.peg.4219
Escherichia coli UTI89 (7-543/548)
V
V
HA
L
RAQ
GV
NT
V
F
G
YP
G
GA
I
MP
V
Y
D
A
L
YDG
-
G
-
V
E
H
L
LC
RHEQ
G
A
AMA
A
I
G
Y
A
RAT
GK
T
GV
--
C
IAT
SGPG
A
TN
L
ITGLA
D
A
LL
D
SI
P
VV
A
I
T
G
QVSAPF
IG
--
T
D
A
FQE
V
D
IL
--------
GLSLACT
K
HSF
LV
QSL
E
E
LP
RI
M
AE
A
FDV
A
S
S
-
GRPG
P
V
L
VD
I
P
K
D
I
QLASGDLE
---
PWFTTVENEV---
-
-TFSHA-E
V
EQ
A
RQM
L
AK
A
QK
P
M
L
YV
G
G
G
VGM
A
Q
A
VSA
L
R
E
FLAATKM
P
ATCT
L
K
GLG
AV
E
AD
Y
P
YYL
GM
L
GM
H
G
TKAANFA
V
Q
EC
D
L
L
IA
VG
A
RF
DD
R
VTGKLNT
F
A
P
-
H
A
SV
IH
M
DIDP
A
E
M
NKLRQAH
VA
L
Q
GD
----
L
NA
LL
PA
L
Q-----Q
PL
N
-
I
DD
W
Q
Q
HCAQL
R
DEHAWRYD--HPG
D
----------------------------
A
-
IYAPLLLKQ
L
SD
----
RKSADCIV
T
T
DVG
QH
QM
W
AA
QH
-
IVHTR
P
E
NF
I
T
S
S
--------
GL
G
T
MG
F
GLP
A
A
V
GA
QV
A
R
P
NDT
VVC
IS
GDG
SFM
M
NVQ
E
LG
T
VK
R
KQ
LP
L
K
IV
LL
D
N
QR
LG
M
V
R
-
QWQQ
L
FFQERYSETTLTDN
-----------
PD
F
LM
LA
S
A
F
G
IP
G
QH
I
THKD
Q
VEA
AL
DTMLNS
---
DG
P
YL
L
HV
S
ID
EL
--------
E
NVW
P
L
V
PP
GA
S
N
S
EM
fig|364106.8.peg.4221
Escherichia coli UTI89 (7-543/548)
V
V
HA
L
RAQ
GV
NT
V
F
G
YP
G
GA
I
MP
V
Y
D
A
L
YDG
-
G
-
V
E
H
L
LC
RHEQ
G
A
AMA
A
I
G
Y
A
RAT
GK
T
GV
--
C
IAT
SGPG
A
TN
L
ITGLA
D
A
LL
D
SI
P
VV
A
I
T
G
QVSAPF
IG
--
T
D
A
FQE
V
D
IL
--------
GLSLACT
K
HSF
LV
QSL
E
E
LP
RI
M
AE
A
FDV
A
S
S
-
GRPG
P
V
L
VD
I
P
K
D
I
QLASGDLE
---
PWFTTVENEV---
-
-TFSHA-E
V
EQ
A
RQM
L
AK
A
QK
P
M
L
YV
G
G
G
VGM
A
Q
A
VSA
L
R
E
FLAATKM
P
ATCT
L
K
GLG
AV
E
AD
Y
P
YYL
GM
L
GM
H
G
TKAANFA
V
Q
EC
D
L
L
IA
VG
A
RF
DD
R
VTGKLNT
F
A
P
-
H
A
SV
IH
M
DIDP
A
E
M
NKLRQAH
VA
L
Q
GD
----
L
NA
LL
PA
L
Q-----Q
PL
N
-
I
DD
W
Q
Q
HCAQL
R
DEHAWRYD--HPG
D
----------------------------
A
-
IYAPLLLKQ
L
SD
----
RKSADCIV
T
T
DVG
QH
QM
W
AA
QH
-
IVHTR
P
E
NF
I
T
S
S
--------
GL
G
T
MG
F
GLP
A
A
V
GA
QV
A
R
P
NDT
VVC
IS
GDG
SFM
M
NVQ
E
LG
T
VK
R
KQ
LP
L
K
IV
LL
D
N
QR
LG
M
V
R
-
QWQQ
L
FFQERYSETTLTDN
-----------
PD
F
LM
LA
S
A
F
G
IP
G
QH
I
THKD
Q
VEA
AL
DTMLNS
---
DG
P
YL
L
HV
S
ID
EL
--------
E
NVW
P
L
V
PP
GA
S
N
S
EM
fig|656417.3.peg.4652
Escherichia coli M605 (7-543/548)
V
V
HA
L
RAQ
GV
NT
V
F
G
YP
G
GA
I
MP
V
Y
D
A
L
YDG
-
G
-
V
E
H
L
LC
RHEQ
G
A
AMA
A
I
G
Y
A
RAT
GK
T
GV
--
C
IAT
SGPG
A
TN
L
ITGLA
D
A
LL
D
SI
P
VV
A
I
T
G
QVSAAF
IG
--
T
D
A
FQE
V
D
IL
--------
GLSLACT
K
HSF
LV
QSL
E
E
LP
RI
M
AE
A
FDV
A
S
S
-
GRPG
P
V
L
VD
I
P
K
D
I
QLASGDLE
---
PWFTTVENEV---
-
-TFPHA-E
V
EQ
A
RQM
L
AK
A
QK
P
M
L
YV
G
G
G
VGM
A
Q
A
VSA
L
R
E
FLAATKM
P
ATCT
L
K
GLG
AV
E
AD
Y
P
YYL
GM
L
GM
H
G
TKAANFA
V
Q
EC
D
L
L
IA
VG
A
RF
DD
R
VTGKLNT
F
A
P
-
H
A
SV
IH
M
DIDP
A
E
M
NKLRQAH
VA
L
Q
GD
----
L
NA
LL
PA
L
Q-----Q
PL
N
-
I
DD
W
Q
Q
HCAQL
R
DEHAWRYD--HPG
D
----------------------------
A
-
IYAPLLLKQ
L
SD
----
RKPADCIV
T
T
DVG
QH
QM
W
AA
QH
-
IVHTR
P
E
NF
I
T
S
S
--------
GL
G
T
MG
F
GLP
A
A
V
GA
QV
A
R
P
NDT
VVC
IS
GDG
SFM
M
NVQ
E
LG
T
VK
R
KQ
LP
L
K
IV
LL
D
N
QR
LG
M
V
R
-
QWQQ
L
FFQERYSETTLTDN
-----------
PD
F
LM
LA
S
A
F
G
IP
G
QH
I
THKD
Q
VEA
AL
DTMLNS
---
DG
P
YL
L
HV
S
ID
EL
--------
E
NVW
P
L
V
PP
GA
S
N
S
EM
fig|431946.3.peg.3755
Escherichia coli SE15 (7-543/548)
V
V
HA
L
RAQ
GV
NT
V
F
G
YP
G
GA
I
MP
V
Y
D
A
L
YDG
-
G
-
V
E
H
L
LC
RHEQ
G
A
AMA
A
I
G
Y
A
RAT
GK
T
GV
--
C
IAT
SGPG
A
TN
L
ITGLA
D
A
LL
D
SI
P
VV
A
I
T
G
QVSAAF
IG
--
T
D
A
FQE
V
D
IL
--------
GLSLACT
K
HSF
LV
QSL
E
E
LP
RI
M
AE
A
FDV
A
S
S
-
GRPG
P
V
L
VD
I
P
K
D
I
QLASGDLE
---
PWFTTVENEV---
-
-TFPHA-E
V
EQ
A
RQM
L
AK
A
QK
P
M
L
YV
G
G
G
VGM
A
Q
A
VSA
L
R
E
FLAATKM
P
ATCT
L
K
GLG
AV
E
AD
Y
P
YYL
GM
L
GM
H
G
TKAANFA
V
Q
EC
D
L
L
IA
VG
A
RF
DD
R
VTGKLNT
F
A
P
-
H
A
SV
IH
M
DIDP
A
E
M
NKLRQAH
VA
L
Q
GD
----
L
NA
LL
PA
L
Q-----Q
PL
N
-
I
DD
W
Q
Q
HCAQL
R
DEHAWRYD--HPG
D
----------------------------
A
-
IYAPLLLKQ
L
SD
----
RKPADCIV
T
T
DVG
QH
QM
W
AA
QH
-
IVHTR
P
E
NF
I
T
S
S
--------
GL
G
T
MG
F
GLP
A
A
V
GA
QV
A
R
P
NDT
VVC
IS
GDG
SFM
M
NVQ
E
LG
T
VK
R
KQ
LP
L
K
IV
LL
D
N
QR
LG
M
V
R
-
QWQQ
L
FFQERYSETTLTDN
-----------
PD
F
LM
LA
S
A
F
G
IP
G
QH
I
THKD
Q
VEA
AL
DTMLNS
---
DG
P
YL
L
HV
S
ID
EL
--------
E
NVW
P
L
V
PP
GA
S
N
S
EM
fig|525281.3.peg.4910
Escherichia coli 83972 (7-543/548)
V
V
HA
L
RAQ
GV
NT
V
F
G
YP
G
GA
I
MP
V
Y
D
A
L
YDG
-
G
-
V
E
H
L
LC
RHEQ
G
A
AMA
A
I
G
Y
A
RAT
GK
T
GV
--
C
IAT
SGPG
A
TN
L
ITGLA
D
A
LL
D
SI
P
VV
A
I
T
G
QVSAPF
IG
--
T
D
A
FQE
V
D
IL
--------
GLSLACT
K
HSF
LV
QSL
E
E
LP
RI
M
AE
A
FDV
A
S
S
-
GRPG
P
V
L
VD
I
P
K
D
I
QLASGDLE
---
PWFTTVENEV---
-
-TFSHA-E
V
EQ
A
RQM
L
AK
A
QK
P
M
L
YV
G
G
G
VGM
A
Q
A
VSA
L
R
E
FLAATKM
P
ATCT
L
K
GLG
AV
E
AD
Y
P
YYL
GM
L
GM
H
G
TKAANFA
V
Q
EC
D
L
L
IA
VG
A
RF
DD
R
VTGKLNT
F
A
P
-
H
A
SV
IH
M
DIDP
A
E
M
NKLRQAH
VA
L
Q
GD
----
L
NA
LL
PA
L
Q-----Q
PL
N
-
I
DD
W
Q
Q
HCAQL
R
DEHAWRYD--HPG
D
----------------------------
A
-
IYAPLLLKQ
L
SD
----
RKPADCIV
T
T
DVG
QH
QM
W
AA
QH
-
IVHTR
P
E
NF
I
T
S
S
--------
GL
G
T
MG
F
GLP
A
A
V
GA
QV
A
R
P
NDT
VVC
IS
GDG
SFM
M
NVQ
E
LG
T
VK
R
KQ
LP
L
K
IV
LL
D
N
QR
LG
M
V
R
-
QWQQ
L
FFQERYSETTLTDN
-----------
PD
F
LM
LA
S
A
F
G
IP
G
QH
I
THKD
Q
VEA
AL
DTMLNS
---
DG
P
YL
L
HV
S
ID
EL
--------
E
NVW
P
L
V
PP
GA
S
N
S
EM
fig|655817.3.peg.4437
Escherichia coli ABU 83972 (7-543/548)
V
V
HA
L
RAQ
GV
NT
V
F
G
YP
G
GA
I
MP
V
Y
D
A
L
YDG
-
G
-
V
E
H
L
LC
RHEQ
G
A
AMA
A
I
G
Y
A
RAT
GK
T
GV
--
C
IAT
SGPG
A
TN
L
ITGLA
D
A
LL
D
SI
P
VV
A
I
T
G
QVSAPF
IG
--
T
D
A
FQE
V
D
IL
--------
GLSLACT
K
HSF
LV
QSL
E
E
LP
RI
M
AE
A
FDV
A
S
S
-
GRPG
P
V
L
VD
I
P
K
D
I
QLASGDLE
---
PWFTTVENEV---
-
-TFSHA-E
V
EQ
A
RQM
L
AK
A
QK
P
M
L
YV
G
G
G
VGM
A
Q
A
VSA
L
R
E
FLAATKM
P
ATCT
L
K
GLG
AV
E
AD
Y
P
YYL
GM
L
GM
H
G
TKAANFA
V
Q
EC
D
L
L
IA
VG
A
RF
DD
R
VTGKLNT
F
A
P
-
H
A
SV
IH
M
DIDP
A
E
M
NKLRQAH
VA
L
Q
GD
----
L
NA
LL
PA
L
Q-----Q
PL
N
-
I
DD
W
Q
Q
HCAQL
R
DEHAWRYD--HPG
D
----------------------------
A
-
IYAPLLLKQ
L
SD
----
RKPADCIV
T
T
DVG
QH
QM
W
AA
QH
-
IVHTR
P
E
NF
I
T
S
S
--------
GL
G
T
MG
F
GLP
A
A
V
GA
QV
A
R
P
NDT
VVC
IS
GDG
SFM
M
NVQ
E
LG
T
VK
R
KQ
LP
L
K
IV
LL
D
N
QR
LG
M
V
R
-
QWQQ
L
FFQERYSETTLTDN
-----------
PD
F
LM
LA
S
A
F
G
IP
G
QH
I
THKD
Q
VEA
AL
DTMLNS
---
DG
P
YL
L
HV
S
ID
EL
--------
E
NVW
P
L
V
PP
GA
S
N
S
EM
fig|199310.1.peg.4591
Escherichia coli CFT073 (7-543/548)
V
V
HA
L
RAQ
GV
NT
V
F
G
YP
G
GA
I
MP
V
Y
D
A
L
YDG
-
G
-
V
E
H
L
LC
RHEQ
G
A
AMA
A
I
G
Y
A
RAT
GK
T
GV
--
C
IAT
SGPG
A
TN
L
ITGLA
D
A
LL
D
SI
P
VV
A
I
T
G
QVSAPF
IG
--
T
D
A
FQE
V
D
IL
--------
GLSLACT
K
HSF
LV
QSL
E
E
LP
RI
M
AE
A
FDV
A
S
S
-
GRPG
P
V
L
VD
I
P
K
D
I
QLASGDLE
---
PWFTTVENEV---
-
-TFSHA-E
V
EQ
A
RQM
L
AK
A
QK
P
M
L
YV
G
G
G
VGM
A
Q
A
VSA
L
R
E
FLAATKM
P
ATCT
L
K
GLG
AV
E
AD
Y
P
YYL
GM
L
GM
H
G
TKAANFA
V
Q
EC
D
L
L
IA
VG
A
RF
DD
R
VTGKLNT
F
A
P
-
H
A
SV
IH
M
DIDP
A
E
M
NKLRQAH
VA
L
Q
GD
----
L
NA
LL
PA
L
Q-----Q
PL
N
-
I
DD
W
Q
Q
HCAQL
R
DEHAWRYD--HPG
D
----------------------------
A
-
IYAPLLLKQ
L
SD
----
RKPADCIV
T
T
DVG
QH
QM
W
AA
QH
-
IVHTR
P
E
NF
I
T
S
S
--------
GL
G
T
MG
F
GLP
A
A
V
GA
QV
A
R
P
NDT
VVC
IS
GDG
SFM
M
NVQ
E
LG
T
VK
R
KQ
LP
L
K
IV
LL
D
N
QR
LG
M
V
R
-
QWQQ
L
FFQERYSETTLTDN
-----------
PD
F
LM
LA
S
A
F
G
IP
G
QH
I
THKD
Q
VEA
AL
DTMLNS
---
DG
P
YL
L
HV
S
ID
EL
--------
E
NVW
P
L
V
PP
GA
S
N
S
EM
fig|199310.4.peg.4401
Escherichia coli CFT073 (7-543/548)
V
V
HA
L
RAQ
GV
NT
V
F
G
YP
G
GA
I
MP
V
Y
D
A
L
YDG
-
G
-
V
E
H
L
LC
RHEQ
G
A
AMA
A
I
G
Y
A
RAT
GK
T
GV
--
C
IAT
SGPG
A
TN
L
ITGLA
D
A
LL
D
SI
P
VV
A
I
T
G
QVSAPF
IG
--
T
D
A
FQE
V
D
IL
--------
GLSLACT
K
HSF
LV
QSL
E
E
LP
RI
M
AE
A
FDV
A
S
S
-
GRPG
P
V
L
VD
I
P
K
D
I
QLASGDLE
---
PWFTTVENEV---
-
-TFSHA-E
V
EQ
A
RQM
L
AK
A
QK
P
M
L
YV
G
G
G
VGM
A
Q
A
VSA
L
R
E
FLAATKM
P
ATCT
L
K
GLG
AV
E
AD
Y
P
YYL
GM
L
GM
H
G
TKAANFA
V
Q
EC
D
L
L
IA
VG
A
RF
DD
R
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F
A
P
-
H
A
SV
IH
M
DIDP
A
E
M
NKLRQAH
VA
L
Q
GD
----
L
NA
LL
PA
L
Q-----Q
PL
N
-
I
DD
W
Q
Q
HCAQL
R
DEHAWRYD--HPG
D
----------------------------
A
-
IYAPLLLKQ
L
SD
----
RKPADCIV
T
T
DVG
QH
QM
W
AA
QH
-
IVHTR
P
E
NF
I
T
S
S
--------
GL
G
T
MG
F
GLP
A
A
V
GA
QV
A
R
P
NDT
VVC
IS
GDG
SFM
M
NVQ
E
LG
T
VK
R
KQ
LP
L
K
IV
LL
D
N
QR
LG
M
V
R
-
QWQQ
L
FFQERYSETTLTDN
-----------
PD
F
LM
LA
S
A
F
G
IP
G
QH
I
THKD
Q
VEA
AL
DTMLNS
---
DG
P
YL
L
HV
S
ID
EL
--------
E
NVW
P
L
V
PP
GA
S
N
S
EM
fig|749546.3.peg.1324
Escherichia coli MS 185-1 (7-543/548)
V
V
HA
L
RAQ
GV
NT
V
F
G
YP
G
GA
I
MP
V
Y
D
A
L
YDG
-
G
-
V
E
H
L
LC
RHEQ
G
A
AMA
A
I
G
Y
A
RAT
GK
T
GV
--
C
IAT
SGPG
A
TN
L
ITGLA
D
A
LL
D
SI
P
VV
A
I
T
G
QVSAPF
IG
--
T
D
A
FQE
V
D
IL
--------
GLSLACT
K
HSF
LV
QSL
E
E
LP
RI
M
AE
A
FDV
A
S
S
-
GRPG
P
V
L
VD
I
P
K
D
I
QLASGDLE
---
PWFTTVENEV---
-
-TFSHA-E
V
EQ
A
RQM
L
AK
A
QK
P
M
L
YV
G
G
G
VGM
A
Q
A
VSA
L
R
E
FLAATKM
P
ATCT
L
K
GLG
AV
E
AD
Y
P
YYL
GM
L
GM
H
G
TKAANFA
V
Q
EC
D
L
L
IA
VG
A
RF
DD
R
VTGKLNT
F
A
P
-
H
A
SV
IH
M
DIDP
A
E
M
NKLRQAH
VA
L
Q
GD
----
L
NA
LL
PA
L
Q-----Q
PL
N
-
I
DD
W
Q
Q
HCAQL
R
DEHAWRYD--HPG
D
----------------------------
A
-
IYAPLLLKQ
L
SD
----
RKPADCIV
T
T
DVG
QH
QM
W
AA
QH
-
IVHTR
P
E
NF
I
T
S
S
--------
GL
G
T
MG
F
GLP
A
A
V
GA
QV
A
R
P
NDT
VVC
IS
GDG
SFM
M
NVQ
E
LG
T
VK
R
KQ
LP
L
K
IV
LL
D
N
QR
LG
M
V
R
-
QWQQ
L
FFQERYSETTLTDN
-----------
PD
F
LM
LA
S
A
F
G
IP
G
QH
I
THKD
Q
VEA
AL
DTMLNS
---
DG
P
YL
L
HV
S
ID
EL
--------
E
NVW
P
L
V
PP
GA
S
N
S
EM
fig|749528.3.peg.3278
Escherichia coli MS 45-1 (7-543/548)
V
V
HA
L
RAQ
GV
NT
V
F
G
YP
G
GA
I
MP
V
Y
D
A
L
YDG
-
G
-
V
E
H
L
LC
RHEQ
G
A
AMA
A
I
G
Y
A
RAT
GK
T
GV
--
C
IAT
SGPG
A
TN
L
ITGLA
D
A
LL
D
SI
P
VV
A
I
T
G
QVSAPF
IG
--
T
D
A
FQE
V
D
IL
--------
GLSLACT
K
HSF
LV
QSL
E
E
LP
RI
M
AE
A
FDV
A
S
S
-
GRPG
P
V
L
VD
I
P
K
D
I
QLASGDLE
---
PWFTTVENEV---
-
-TFSHA-E
V
EQ
A
RQM
L
AK
A
QK
P
M
L
YV
G
G
G
VGM
A
Q
A
VSA
L
R
E
FLAATKM
P
ATCT
L
K
GLG
AV
E
AD
Y
P
YYL
GM
L
GM
H
G
TKAANFA
V
Q
EC
D
L
L
IA
VG
A
RF
DD
R
VTGKLNT
F
A
P
-
H
A
SV
IH
M
DIDP
A
E
M
NKLRQAH
VA
L
Q
GD
----
L
NA
LL
PA
L
Q-----Q
PL
N
-
I
DD
W
Q
Q
HCAQL
R
DEHAWRYD--HPG
D
----------------------------
A
-
IYAPLLLKQ
L
SD
----
RKPADCIV
T
T
DVG
QH
QM
W
AA
QH
-
IVHTR
P
E
NF
I
T
S
S
--------
GL
G
T
MG
F
GLP
A
A
V
GA
QV
A
R
P
NDT
VVC
IS
GDG
SFM
M
NVQ
E
LG
T
VK
R
KQ
LP
L
K
IV
LL
D
N
QR
LG
M
V
R
-
QWQQ
L
FFQERYSETTLTDN
-----------
PD
F
LM
LA
S
A
F
G
IP
G
QH
I
THKD
Q
VEA
AL
DTMLNS
---
DG
P
YL
L
HV
S
ID
EL
--------
E
NVW
P
L
V
PP
GA
S
N
S
EM
fig|562.376.peg.728
Escherichia coli WV_060327 (7-543/548)
V
V
HA
L
RAQ
GV
NT
V
F
G
YP
G
GA
I
MP
V
Y
D
A
L
YDG
-
G
-
V
E
H
L
LC
RHEQ
G
A
AMA
A
I
G
Y
A
RAT
GK
T
GV
--
C
IAT
SGPG
A
TN
L
ITGLA
D
A
LL
D
SI
P
VV
A
I
T
G
QVSAPF
IG
--
T
D
A
FQE
V
D
IL
--------
GLSLACT
K
HSF
LV
QSL
E
E
LP
RI
M
AE
A
FDV
A
S
S
-
GRPG
P
V
L
VD
I
P
K
D
I
QLASGDLE
---
PWFTTVENEV---
-
-TFSHA-E
V
EQ
A
RQM
L
AK
A
QK
P
M
L
YV
G
G
G
VGM
A
Q
A
VSA
L
R
E
FLAATKM
P
ATCT
L
K
GLG
AV
E
AD
Y
P
YYL
GM
L
GM
H
G
TKAANFA
V
Q
EC
D
L
L
IA
VG
A
RF
DD
R
VTGKLNT
F
A
P
-
H
A
SV
IH
M
DIDP
A
E
M
NKLRQAH
VA
L
Q
GD
----
L
NA
LL
PA
L
Q-----Q
PL
N
-
I
DD
W
Q
Q
HCAQL
R
DEHAWRYD--HPG
D
----------------------------
A
-
IYAPLLLKQ
L
SD
----
RKPADCIV
T
T
DVG
QH
QM
W
AA
QH
-
IVHTR
P
E
NF
I
T
S
S
--------
GL
G
T
MG
F
GLP
A
A
V
GA
QV
A
R
P
NDT
VVC
IS
GDG
SFM
M
NVQ
E
LG
T
VK
R
KQ
LP
L
K
IV
LL
D
N
QR
LG
M
V
R
-
QWQQ
L
FFQERYSETTLTDN
-----------
PD
F
LM
LA
S
A
F
G
IP
G
QH
I
THKD
Q
VEA
AL
DTMLNS
---
DG
P
YL
L
HV
S
ID
EL
--------
E
NVW
P
L
V
PP
GA
S
N
S
EM
fig|405955.13.peg.4216
Escherichia coli APEC O1 (1-537/542)
M
V
HA
L
RAQ
GV
NT
V
F
G
YP
G
GA
I
MP
V
Y
D
A
L
YDG
-
G
-
V
E
H
L
LC
RHEQ
G
A
AMA
A
I
G
Y
A
RAT
GK
T
GV
--
C
IAT
SGPG
A
TN
L
ITGLA
D
A
LL
D
SI
P
VV
A
I
T
G
QVSAPF
IG
--
T
D
A
FQE
V
D
IL
--------
GLSLACT
K
HSF
LV
QSL
E
E
LP
RI
M
AE
A
FDV
A
S
S
-
GRPG
P
V
L
VD
I
P
K
D
I
QLASGDLE
---
PWFTTVENEV---
-
-TFSHA-E
V
EQ
A
RQM
L
AK
A
QK
P
M
L
YV
G
G
G
VGM
A
Q
A
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L
R
E
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P
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K
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AV
E
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Y
P
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L
GM
H
G
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V
Q
EC
D
L
L
IA
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A
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R
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A
P
-
H
A
SV
IH
M
DIDP
A
E
M
NKLRQAH
VA
L
Q
GD
----
L
NA
LL
PA
L
Q-----Q
PL
N
-
I
DD
W
Q
Q
HCAQL
R
DEHAWRYD--HPG
D
----------------------------
A
-
IYAPLLLKQ
L
SD
----
RKSADCIV
T
T
DVG
QH
QM
W
AA
QH
-
IVHTR
P
E
NF
I
T
S
S
--------
GL
G
T
MG
F
GLP
A
A
V
GA
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A
R
P
NDT
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IS
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M
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E
LG
T
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R
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LP
L
K
IV
LL
D
N
QR
LG
M
V
R
-
QWQQ
L
FFQERYSETTLTDN
-----------
PD
F
LM
LA
S
A
F
G
IP
G
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I
THKD
Q
VEA
AL
DTMLNS
---
DG
P
YL
L
HV
S
ID
EL
--------
E
NVW
P
L
V
PP
GA
S
N
S
EM
fig|585397.7.peg.4446
Escherichia coli ED1a (1-537/542)
M
V
HA
L
RAQ
GV
NT
V
F
G
YP
G
GA
I
MP
V
Y
D
A
L
YDG
-
G
-
V
E
H
L
LC
RHEQ
G
A
AMA
A
I
G
Y
A
RAT
GK
T
GV
--
C
IAT
SGPG
A
TN
L
ITGLA
D
A
LL
D
SI
P
VV
A
I
T
G
QVSAPF
IG
--
T
D
A
FQE
V
D
IL
--------
GLSLACT
K
HSF
LV
QSL
E
E
LP
RI
M
AE
A
FDV
A
S
S
-
GRPG
P
V
L
VD
I
P
K
D
I
QLASGDLE
---
PWFTTVENEV---
-
-TFSHA-E
V
EQ
A
RQM
L
AK
A
QK
P
M
L
YV
G
G
G
VGM
A
Q
A
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L
R
E
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P
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L
K
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AV
E
AD
Y
P
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L
GM
H
G
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V
Q
EC
D
L
L
IA
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A
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P
-
H
A
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IH
M
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A
E
M
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L
Q
GD
----
L
NA
LL
PA
L
Q-----Q
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N
-
I
DD
W
Q
Q
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R
DEHAWRYD--HPG
D
----------------------------
A
-
IYAPLLLKQ
L
SD
----
RKSADCIV
T
T
DVG
QH
QM
W
AA
QH
-
IVHTR
P
E
NF
I
T
S
S
--------
GL
G
T
MG
F
GLP
A
A
V
GA
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A
R
P
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IS
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M
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R
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LP
L
K
IV
LL
D
N
QR
LG
M
V
R
-
QWQQ
L
FFQERYSETTLTDN
-----------
PD
F
LM
LA
S
A
F
G
IP
G
QH
I
THKD
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VEA
AL
DTMLNS
---
DG
P
YL
L
HV
S
ID
EL
--------
E
NVW
P
L
V
PP
GA
S
N
S
EM
fig|585035.6.peg.4113
Escherichia coli S88 (1-537/542)
M
V
HA
L
RAQ
GV
NT
V
F
G
YP
G
GA
I
MP
V
Y
D
A
L
YDG
-
G
-
V
E
H
L
LC
RHEQ
G
A
AMA
A
I
G
Y
A
RAT
GK
T
GV
--
C
IAT
SGPG
A
TN
L
ITGLA
D
A
LL
D
SI
P
VV
A
I
T
G
QVSAPF
IG
--
T
D
A
FQE
V
D
IL
--------
GLSLACT
K
HSF
LV
QSL
E
E
LP
RI
M
AE
A
FDV
A
S
S
-
GRPG
P
V
L
VD
I
P
K
D
I
QLASGDLE
---
PWFTTVENEV---
-
-TFSHA-E
V
EQ
A
RQM
L
AK
A
QK
P
M
L
YV
G
G
G
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A
Q
A
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L
R
E
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P
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L
K
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AV
E
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Y
P
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L
GM
H
G
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Q
EC
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L
L
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H
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M
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M
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L
Q
GD
----
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NA
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L
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Q
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R
DEHAWRYD--HPG
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----------------------------
A
-
IYAPLLLKQ
L
SD
----
RKSADCIV
T
T
DVG
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W
AA
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P
E
NF
I
T
S
S
--------
GL
G
T
MG
F
GLP
A
A
V
GA
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A
R
P
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M
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L
K
IV
LL
D
N
QR
LG
M
V
R
-
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FFQERYSETTLTDN
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PD
F
LM
LA
S
A
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I
THKD
Q
VEA
AL
DTMLNS
---
DG
P
YL
L
HV
S
ID
EL
--------
E
NVW
P
L
V
PP
GA
S
N
S
EM
fig|753642.3.peg.3413
Escherichia coli NC101 (7-543/548)
V
V
HA
L
RAQ
GV
NT
V
F
G
YP
G
GA
I
MP
V
Y
D
A
L
YDG
-
G
-
V
E
H
L
LC
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G
A
AMA
A
I
G
Y
A
RAT
GK
T
GV
--
C
IAT
SGPG
A
TN
L
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A
LL
D
SI
P
VV
A
I
T
G
QVSAPF
IG
--
T
D
A
FQE
V
D
VL
--------
GLSLACT
K
HSF
LV
QSL
E
E
LP
RI
M
AE
A
FDV
A
S
S
-
GRPG
P
V
L
VD
I
P
K
D
I
QLASGDLE
---
PWFTTVENEV---
-
-TFPHA-E
V
EQ
A
RQM
L
AK
A
QK
P
M
L
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G
G
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A
Q
A
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L
R
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K
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L
GM
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V
Q
EC
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L
L
IA
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H
A
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M
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M
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L
Q
GD
----
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NA
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PA
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Q-----Q
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-
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R
DEHTWRYD--HPG
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----------------------------
A
-
IYAPLLLKQ
L
SD
----
RKPADCVV
T
T
DVG
QH
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W
AA
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-
IAHTR
P
E
NF
I
T
S
S
--------
GL
G
T
MG
F
GLP
A
A
V
GA
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A
R
P
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L
K
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LL
D
N
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LG
M
V
R
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L
FFQERYSETTLTDN
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PD
F
LM
LA
S
A
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G
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---
DG
P
YL
L
HV
S
ID
EL
--------
E
NVW
P
L
V
PP
GA
S
N
S
EM
fig|656440.3.peg.4078
Escherichia coli TA206 (7-543/548)
V
V
HA
L
RAQ
GV
NT
V
F
G
YP
G
GA
I
MP
V
Y
D
A
L
YDG
-
G
-
V
E
H
L
LC
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G
A
AMA
A
I
G
Y
A
RAT
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T
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--
C
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TN
L
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A
LL
D
SI
P
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A
I
T
G
QVSAPF
IG
--
T
D
A
FQE
V
D
IL
--------
GLSLACT
K
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LV
QSL
E
E
LP
RI
M
AE
A
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A
S
S
-
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P
V
L
VD
I
P
K
D
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QLASGDLE
---
PWFTTVENEV---
-
-TFSHA-E
V
EQ
A
RQM
L
AK
A
QK
P
M
L
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G
G
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Q
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R
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P
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L
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V
Q
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L
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IA
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M
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A
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M
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L
Q
GD
----
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NA
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PA
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Q-----Q
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-
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R
DEHTWRYD--HPG
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----------------------------
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-
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SD
----
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T
T
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W
AA
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-
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P
E
NF
I
T
S
S
--------
GL
G
T
MG
F
GLP
A
A
V
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A
R
P
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L
K
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D
N
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LG
M
V
R
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L
FFQERYSETTLTDN
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F
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LA
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A
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G
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---
DG
P
YL
L
HV
S
ID
EL
--------
E
NVW
P
L
V
PP
GA
S
N
S
EM
fig|670897.3.peg.5145
Escherichia coli 2362-75 (7-543/548)
V
V
HA
L
RAQ
GV
NT
V
F
G
YP
G
GA
I
MP
V
Y
D
A
L
YDG
-
G
-
V
E
H
L
LC
RHEQ
G
A
AMA
A
I
G
Y
A
RAT
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T
GV
--
C
IAT
SGPG
A
TN
L
ITGLA
D
A
LL
D
SI
P
VV
A
I
T
G
QVSAPF
IG
--
T
D
A
FQE
V
D
IL
--------
GLSLACT
K
HSF
LV
QSL
E
E
LP
RI
M
AE
A
FDV
A
S
S
-
GRPG
P
V
L
VD
I
P
K
D
I
QLASGDLE
---
PWFTTVENEV---
-
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V
EQ
A
RQM
L
AK
A
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P
M
L
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G
G
G
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A
Q
A
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L
R
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FLAATKM
P
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L
K
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AV
E
AD
Y
P
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GM
L
GM
H
G
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V
Q
EC
D
L
L
IA
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A
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H
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IH
M
DIDP
A
E
M
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L
Q
GD
----
L
NA
LL
PA
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Q-----Q
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N
-
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ND
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Q
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R
DEHTWRYD--HPG
D
----------------------------
A
-
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L
SD
----
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T
T
DVG
QH
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W
AA
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-
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P
E
NF
I
T
S
S
--------
GL
G
T
MG
F
GLP
A
A
V
GA
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A
R
P
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IS
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M
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E
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T
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LP
L
K
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LL
D
N
QR
LG
M
V
R
-
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L
FFQERYSETTLTDN
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PD
F
LM
LA
S
A
F
G
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G
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I
TRKD
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AL
DTMLNS
---
DG
P
YL
L
HV
S
ID
EL
--------
E
NVW
P
L
V
PP
GA
S
N
S
EM
fig|216593.1.peg.4575
Escherichia coli E2348/69 (7-543/548)
V
V
HA
L
RAQ
GV
NT
V
F
G
YP
G
GA
I
MP
V
Y
D
A
L
YDG
-
G
-
V
E
H
L
LC
RHEQ
G
A
AMA
A
I
G
Y
A
RAT
GK
T
GV
--
C
IAT
SGPG
A
TN
L
ITGLA
D
A
LL
D
SI
P
VV
A
I
T
G
QVSAPF
IG
--
T
D
A
FQE
V
D
IL
--------
GLSLACT
K
HSF
LV
QSL
E
E
LP
RI
M
AE
A
FDV
A
S
S
-
GRPG
P
V
L
VD
I
P
K
D
I
QLASGDLE
---
PWFTTVENEV---
-
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V
EQ
A
RQM
L
AK
A
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P
M
L
YV
G
G
G
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A
Q
A
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L
R
E
FLAATKM
P
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L
K
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AV
E
AD
Y
P
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GM
L
GM
H
G
TKAANFA
V
Q
EC
D
L
L
IA
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A
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A
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-
H
A
SV
IH
M
DIDP
A
E
M
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L
Q
GD
----
L
NA
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PA
L
Q-----Q
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N
-
I
ND
W
Q
Q
YCAQL
R
DEHTWRYD--HPG
D
----------------------------
A
-
IYAPLLLKQ
L
SD
----
RKPADCVV
T
T
DVG
QH
QM
W
AA
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-
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P
E
NF
I
T
S
S
--------
GL
G
T
MG
F
GLP
A
A
V
GA
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A
R
P
NDT
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IS
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M
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E
LG
T
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R
KQ
LP
L
K
IV
LL
D
N
QR
LG
M
V
R
-
QWQQ
L
FFQERYSETTLTDN
-----------
PD
F
LM
LA
S
A
F
G
IP
G
QH
I
TRKD
Q
VEA
AL
DTMLNS
---
DG
P
YL
L
HV
S
ID
EL
--------
E
NVW
P
L
V
PP
GA
S
N
S
EM
fig|574521.7.peg.4149
Escherichia coli O127:H6 str. E2348/69 (7-543/548)
V
V
HA
L
RAQ
GV
NT
V
F
G
YP
G
GA
I
MP
V
Y
D
A
L
YDG
-
G
-
V
E
H
L
LC
RHEQ
G
A
AMA
A
I
G
Y
A
RAT
GK
T
GV
--
C
IAT
SGPG
A
TN
L
ITGLA
D
A
LL
D
SI
P
VV
A
I
T
G
QVSAPF
IG
--
T
D
A
FQE
V
D
IL
--------
GLSLACT
K
HSF
LV
QSL
E
E
LP
RI
M
AE
A
FDV
A
S
S
-
GRPG
P
V
L
VD
I
P
K
D
I
QLASGDLE
---
PWFTTVENEV---
-
-TFPHA-E
V
EQ
A
RQM
L
AK
A
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P
M
L
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G
G
G
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A
Q
A
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L
R
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FLAATKM
P
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K
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AV
E
AD
Y
P
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GM
L
GM
H
G
TKAANFA
V
Q
EC
D
L
L
IA
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P
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H
A
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M
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A
E
M
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L
Q
GD
----
L
NA
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PA
L
Q-----Q
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N
-
I
ND
W
Q
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R
DEHTWRYD--HPG
D
----------------------------
A
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IYAPLLLKQ
L
SD
----
RKPADCVV
T
T
DVG
QH
QM
W
AA
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-
IAHTR
P
E
NF
I
T
S
S
--------
GL
G
T
MG
F
GLP
A
A
V
GA
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A
R
P
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M
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E
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T
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R
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LP
L
K
IV
LL
D
N
QR
LG
M
V
R
-
QWQQ
L
FFQERYSETTLTDN
-----------
PD
F
LM
LA
S
A
F
G
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G
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I
TRKD
Q
VEA
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---
DG
P
YL
L
HV
S
ID
EL
--------
E
NVW
P
L
V
PP
GA
S
N
S
EM
fig|685038.3.peg.3823
Escherichia coli O83:H1 str. NRG 857C (7-543/548)
V
V
HA
L
RAQ
GV
NT
V
F
G
YP
G
GA
I
MP
V
Y
D
A
L
YDG
-
G
-
V
E
H
L
LC
RHEQ
G
A
AMA
A
I
G
Y
A
RAT
GK
T
GV
--
C
IAT
SGPG
A
TN
L
ITGLA
D
A
LL
D
SI
P
VV
A
I
T
G
QVSAPF
IG
--
T
D
A
FQE
V
D
IL
--------
GLSLACT
K
HSF
LV
QSL
E
E
LP
RI
M
AE
A
FDV
A
S
S
-
GRPG
P
V
L
VD
I
P
K
D
I
QLASGDLE
---
PWFTTVENEV---
-
-TFPHA-E
V
EQ
A
RQM
L
AK
A
QK
P
M
L
YV
G
G
G
VGM
A
Q
A
VSA
L
R
E
FLAATKM
P
ATCT
L
K
GLG
AV
E
AD
Y
P
YYL
GM
L
GM
H
G
TKAANFA
V
Q
EC
D
L
L
IA
VG
A
RF
DD
R
VTGKLNT
F
A
P
-
H
A
SV
IH
M
DIDP
A
E
M
NKLRQAH
VA
L
Q
GD
----
L
NA
LL
PA
L
Q-----Q
PL
N
-
I
ND
W
Q
Q
YCAQL
R
DEHTRRYD--HPG
D
----------------------------
A
-
IYAPLLLKQ
L
SD
----
RKPADCVV
T
T
DVG
QH
QM
W
AA
QH
-
IAHTR
P
E
NF
I
T
S
S
--------
GL
G
T
MG
F
GLP
A
A
V
GA
QV
A
R
P
NDT
VVC
IS
GDG
SFM
M
NVQ
E
LG
T
VK
R
KQ
LP
L
K
IV
LL
D
N
QR
LG
M
V
R
-
QWQQ
L
FFQERYSETTLTDN
-----------
PD
F
LM
LA
S
A
F
G
IP
G
QH
I
TRKD
Q
VEA
AL
DTMLNS
---
DG
P
YL
L
HV
S
ID
EL
--------
E
NVW
P
L
V
PP
GA
S
N
S
EM
fig|562.371.peg.5547
Escherichia coli 1044A (7-543/548)
V
V
HA
L
RAQ
GV
NT
V
F
G
YP
G
GA
I
MP
V
Y
D
A
L
YDG
-
G
-
V
E
H
L
LC
RHEQ
G
A
AMA
A
I
G
Y
A
RAT
GK
T
GV
--
C
IAT
SGPG
A
TN
L
ITGLA
D
A
LL
D
SI
P
VV
A
I
T
G
QVSAPF
IG
--
T
D
A
FQE
V
D
VL
--------
GLSLACT
K
HSF
LV
QSL
E
E
LP
RI
M
AE
A
FDV
A
S
S
-
GRPG
P
V
L
VD
I
P
K
D
I
QLASGDLE
---
PWFTTVENEV---
-
-TFPHA-E
V
EQ
A
RQM
L
AK
A
QK
P
M
L
YV
G
G
G
VGM
A
Q
A
VPA
L
R
E
FLATTKM
P
ATCT
L
K
GLG
AV
E
AD
Y
P
YYL
GM
L
GM
H
G
TKAANFA
V
Q
EC
D
L
L
IA
VG
A
RF
DD
R
VTGKLNT
F
A
P
-
H
A
SV
IH
M
DIDP
A
E
M
NKLRQAH
VA
L
Q
GD
----
L
NA
LL
PA
L
Q-----Q
PL
N
-
I
ND
W
Q
Q
YCAQL
R
DEHAWRYD--HPG
D
----------------------------
A
-
IYAPLLLKQ
L
SD
----
RKPADCVV
T
T
DVG
QH
QM
W
AA
QH
-
IAHTR
P
E
NF
I
T
S
S
--------
GL
G
T
MG
F
GLP
A
A
V
GA
QV
A
R
P
NDT
VVC
IS
GDG
SFM
M
NVQ
E
LG
T
VK
R
KQ
LP
L
K
IV
LL
D
N
QR
LG
M
V
R
-
QWQQ
L
FFQERYSETTLTDN
-----------
PD
F
LK
LA
S
A
F
G
IP
G
QH
I
TRKD
Q
VEA
AL
DTMLNS
---
DG
P
YL
L
HV
S
ID
EL
--------
E
NVW
P
L
V
PP
GA
S
N
S
EM
fig|562.373.peg.5933
Escherichia coli 1125A (7-543/548)
V
V
HA
L
RAQ
GV
NT
V
F
G
YP
G
GA
I
MP
V
Y
D
A
L
YDG
-
G
-
V
E
H
L
LC
RHEQ
G
A
AMA
A
I
G
Y
A
RAT
GK
T
GV
--
C
IAT
SGPG
A
TN
L
ITGLA
D
A
LL
D
SI
P
VV
A
I
T
G
QVSAPF
IG
--
T
D
A
FQE
V
D
VL
--------
GLSLACT
K
HSF
LV
QSL
E
E
LP
RI
M
AE
A
FDV
A
S
S
-
GRPG
P
V
L
VD
I
P
K
D
I
QLASGDLE
---
PWFTTVENEV---
-
-TFPHA-E
V
EQ
A
RQM
L
AK
A
QK
P
M
L
YV
G
G
G
VGM
A
Q
A
VPA
L
R
E
FLATTKM
P
ATCT
L
K
GLG
AV
E
AD
Y
P
YYL
GM
L
GM
H
G
TKAANFA
V
Q
EC
D
L
L
IA
VG
A
RF
DD
R
VTGKLNT
F
A
P
-
H
A
SV
IH
M
DIDP
A
E
M
NKLRQAH
VA
L
Q
GD
----
L
NA
LL
PA
L
Q-----Q
PL
N
-
I
ND
W
Q
Q
YCAQL
R
DEHAWRYD--HPG
D
----------------------------
A
-
IYAPLLLKQ
L
SD
----
RKPADCVV
T
T
DVG
QH
QM
W
AA
QH
-
IAHTR
P
E
NF
I
T
S
S
--------
GL
G
T
MG
F
GLP
A
A
V
GA
QV
A
R
P
NDT
VVC
IS
GDG
SFM
M
NVQ
E
LG
T
VK
R
KQ
LP
L
K
IV
LL
D
N
QR
LG
M
V
R
-
QWQQ
L
FFQERYSETTLTDN
-----------
PD
F
LK
LA
S
A
F
G
IP
G
QH
I
TRKD
Q
VEA
AL
DTMLNS
---
DG
P
YL
L
HV
S
ID
EL
--------
E
NVW
P
L
V
PP
GA
S
N
S
EM
fig|562.372.peg.3844
Escherichia coli 1212A (7-543/548)
V
V
HA
L
RAQ
GV
NT
V
F
G
YP
G
GA
I
MP
V
Y
D
A
L
YDG
-
G
-
V
E
H
L
LC
RHEQ
G
A
AMA
A
I
G
Y
A
RAT
GK
T
GV
--
C
IAT
SGPG
A
TN
L
ITGLA
D
A
LL
D
SI
P
VV
A
I
T
G
QVSAPF
IG
--
T
D
A
FQE
V
D
VL
--------
GLSLACT
K
HSF
LV
QSL
E
E
LP
RI
M
AE
A
FDV
A
S
S
-
GRPG
P
V
L
VD
I
P
K
D
I
QLASGDLE
---
PWFTTVENEV---
-
-TFPHA-E
V
EQ
A
RQM
L
AK
A
QK
P
M
L
YV
G
G
G
VGM
A
Q
A
VPA
L
R
E
FLATTKM
P
ATCT
L
K
GLG
AV
E
AD
Y
P
YYL
GM
L
GM
H
G
TKAANFA
V
Q
EC
D
L
L
IA
VG
A
RF
DD
R
VTGKLNT
F
A
P
-
H
A
SV
IH
M
DIDP
A
E
M
NKLRQAH
VA
L
Q
GD
----
L
NA
LL
PA
L
Q-----Q
PL
N
-
I
ND
W
Q
Q
YCAQL
R
DEHAWRYD--HPG
D
----------------------------
A
-
IYAPLLLKQ
L
SD
----
RKPADCVV
T
T
DVG
QH
QM
W
AA
QH
-
IAHTR
P
E
NF
I
T
S
S
--------
GL
G
T
MG
F
GLP
A
A
V
GA
QV
A
R
P
NDT
VVC
IS
GDG
SFM
M
NVQ
E
LG
T
VK
R
KQ
LP
L
K
IV
LL
D
N
QR
LG
M
V
R
-
QWQQ
L
FFQERYSETTLTDN
-----------
PD
F
LK
LA
S
A
F
G
IP
G
QH
I
TRKD
Q
VEA
AL
DTMLNS
---
DG
P
YL
L
HV
S
ID
EL
--------
E
NVW
P
L
V
PP
GA
S
N
S
EM
fig|562.374.peg.708
Escherichia coli 536A (7-543/548)
V
V
HA
L
RAQ
GV
NT
V
F
G
YP
G
GA
I
MP
V
Y
D
A
L
YDG
-
G
-
V
E
H
L
LC
RHEQ
G
A
AMA
A
I
G
Y
A
RAT
GK
T
GV
--
C
IAT
SGPG
A
TN
L
ITGLA
D
A
LL
D
SI
P
VV
A
I
T
G
QVSAPF
IG
--
T
D
A
FQE
V
D
VL
--------
GLSLACT
K
HSF
LV
QSL
E
E
LP
RI
M
AE
A
FDV
A
S
S
-
GRPG
P
V
L
VD
I
P
K
D
I
QLASGDLE
---
PWFTTVENEV---
-
-TFPHA-E
V
EQ
A
RQM
L
AK
A
QK
P
M
L
YV
G
G
G
VGM
A
Q
A
VPA
L
R
E
FLATTKM
P
ATCT
L
K
GLG
AV
E
AD
Y
P
YYL
GM
L
GM
H
G
TKAANFA
V
Q
EC
D
L
L
IA
VG
A
RF
DD
R
VTGKLNT
F
A
P
-
H
A
SV
IH
M
DIDP
A
E
M
NKLRQAH
VA
L
Q
GD
----
L
NA
LL
PA
L
Q-----Q
PL
N
-
I
ND
W
Q
Q
YCAQL
R
DEHAWRYD--HPG
D
----------------------------
A
-
IYAPLLLKQ
L
SD
----
RKPADCVV
T
T
DVG
QH
QM
W
AA
QH
-
IAHTR
P
E
NF
I
T
S
S
--------
GL
G
T
MG
F
GLP
A
A
V
GA
QV
A
R
P
NDT
VVC
IS
GDG
SFM
M
NVQ
E
LG
T
VK
R
KQ
LP
L
K
IV
LL
D
N
QR
LG
M
V
R
-
QWQQ
L
FFQERYSETTLTDN
-----------
PD
F
LK
LA
S
A
F
G
IP
G
QH
I
TRKD
Q
VEA
AL
DTMLNS
---
DG
P
YL
L
HV
S
ID
EL
--------
E
NVW
P
L
V
PP
GA
S
N
S
EM
fig|83334.1.peg.4673
Escherichia coli O157:H7 (7-543/548)
V
V
HA
L
RAQ
GV
NT
V
F
G
YP
G
GA
I
MP
V
Y
D
A
L
YDG
-
G
-
V
E
H
L
LC
RHEQ
G
A
AMA
A
I
G
Y
A
RAT
GK
T
GV
--
C
IAT
SGPG
A
TN
L
ITGLA
D
A
LL
D
SI
P
VV
A
I
T
G
QVSAPF
IG
--
T
D
A
FQE
V
D
VL
--------
GLSLACT
K
HSF
LV
QSL
E
E
LP
RI
M
AE
A
FDV
A
S
S
-
GRPG
P
V
L
VD
I
P
K
D
I
QLASGDLE
---
PWFTTVENEV---
-
-TFPHA-E
V
EQ
A
RQM
L
AK
A
QK
P
M
L
YV
G
G
G
VGM
A
Q
A
VPA
L
R
E
FLATTKM
P
ATCT
L
K
GLG
AV
E
AD
Y
P
YYL
GM
L
GM
H
G
TKAANFA
V
Q
EC
D
L
L
IA
VG
A
RF
DD
R
VTGKLNT
F
A
P
-
H
A
SV
IH
M
DIDP
A
E
M
NKLRQAH
VA
L
Q
GD
----
L
NA
LL
PA
L
Q-----Q
PL
N
-
I
ND
W
Q
Q
YCAQL
R
DEHAWRYD--HPG
D
----------------------------
A
-
IYAPLLLKQ
L
SD
----
RKPADCVV
T
T
DVG
QH
QM
W
AA
QH
-
IAHTR
P
E
NF
I
T
S
S
--------
GL
G
T
MG
F
GLP
A
A
V
GA
QV
A
R
P
NDT
VVC
IS
GDG
SFM
M
NVQ
E
LG
T
VK
R
KQ
LP
L
K
IV
LL
D
N
QR
LG
M
V
R
-
QWQQ
L
FFQERYSETTLTDN
-----------
PD
F
LK
LA
S
A
F
G
IP
G
QH
I
TRKD
Q
VEA
AL
DTMLNS
---
DG
P
YL
L
HV
S
ID
EL
--------
E
NVW
P
L
V
PP
GA
S
N
S
EM
fig|155864.1.peg.4707
Escherichia coli O157:H7 EDL933 (7-543/548)
V
V
HA
L
RAQ
GV
NT
V
F
G
YP
G
GA
I
MP
V
Y
D
A
L
YDG
-
G
-
V
E
H
L
LC
RHEQ
G
A
AMA
A
I
G
Y
A
RAT
GK
T
GV
--
C
IAT
SGPG
A
TN
L
ITGLA
D
A
LL
D
SI
P
VV
A
I
T
G
QVSAPF
IG
--
T
D
A
FQE
V
D
VL
--------
GLSLACT
K
HSF
LV
QSL
E
E
LP
RI
M
AE
A
FDV
A
S
S
-
GRPG
P
V
L
VD
I
P
K
D
I
QLASGDLE
---
PWFTTVENEV---
-
-TFPHA-E
V
EQ
A
RQM
L
AK
A
QK
P
M
L
YV
G
G
G
VGM
A
Q
A
VPA
L
R
E
FLATTKM
P
ATCT
L
K
GLG
AV
E
AD
Y
P
YYL
GM
L
GM
H
G
TKAANFA
V
Q
EC
D
L
L
IA
VG
A
RF
DD
R
VTGKLNT
F
A
P
-
H
A
SV
IH
M
DIDP
A
E
M
NKLRQAH
VA
L
Q
GD
----
L
NA
LL
PA
L
Q-----Q
PL
N
-
I
ND
W
Q
Q
YCAQL
R
DEHAWRYD--HPG
D
----------------------------
A
-
IYAPLLLKQ
L
SD
----
RKPADCVV
T
T
DVG
QH
QM
W
AA
QH
-
IAHTR
P
E
NF
I
T
S
S
--------
GL
G
T
MG
F
GLP
A
A
V
GA
QV
A
R
P
NDT
VVC
IS
GDG
SFM
M
NVQ
E
LG
T
VK
R
KQ
LP
L
K
IV
LL
D
N
QR
LG
M
V
R
-
QWQQ
L
FFQERYSETTLTDN
-----------
PD
F
LK
LA
S
A
F
G
IP
G
QH
I
TRKD
Q
VEA
AL
DTMLNS
---
DG
P
YL
L
HV
S
ID
EL
--------
E
NVW
P
L
V
PP
GA
S
N
S
EM
fig|155864.8.peg.4665
Escherichia coli O157:H7 EDL933 (7-543/548)
V
V
HA
L
RAQ
GV
NT
V
F
G
YP
G
GA
I
MP
V
Y
D
A
L
YDG
-
G
-
V
E
H
L
LC
RHEQ
G
A
AMA
A
I
G
Y
A
RAT
GK
T
GV
--
C
IAT
SGPG
A
TN
L
ITGLA
D
A
LL
D
SI
P
VV
A
I
T
G
QVSAPF
IG
--
T
D
A
FQE
V
D
VL
--------
GLSLACT
K
HSF
LV
QSL
E
E
LP
RI
M
AE
A
FDV
A
S
S
-
GRPG
P
V
L
VD
I
P
K
D
I
QLASGDLE
---
PWFTTVENEV---
-
-TFPHA-E
V
EQ
A
RQM
L
AK
A
QK
P
M
L
YV
G
G
G
VGM
A
Q
A
VPA
L
R
E
FLATTKM
P
ATCT
L
K
GLG
AV
E
AD
Y
P
YYL
GM
L
GM
H
G
TKAANFA
V
Q
EC
D
L
L
IA
VG
A
RF
DD
R
VTGKLNT
F
A
P
-
H
A
SV
IH
M
DIDP
A
E
M
NKLRQAH
VA
L
Q
GD
----
L
NA
LL
PA
L
Q-----Q
PL
N
-
I
ND
W
Q
Q
YCAQL
R
DEHAWRYD--HPG
D
----------------------------
A
-
IYAPLLLKQ
L
SD
----
RKPADCVV
T
T
DVG
QH
QM
W
AA
QH
-
IAHTR
P
E
NF
I
T
S
S
--------
GL
G
T
MG
F
GLP
A
A
V
GA
QV
A
R
P
NDT
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IS
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M
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E
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T
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R
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LP
L
K
IV
LL
D
N
QR
LG
M
V
R
-
QWQQ
L
FFQERYSETTLTDN
-----------
PD
F
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S
A
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G
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G
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I
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AL
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---
DG
P
YL
L
HV
S
ID
EL
--------
E
NVW
P
L
V
PP
GA
S
N
S
EM
fig|444454.5.peg.3790
Escherichia coli O157:H7 str. EC4024 (7-543/548)
V
V
HA
L
RAQ
GV
NT
V
F
G
YP
G
GA
I
MP
V
Y
D
A
L
YDG
-
G
-
V
E
H
L
LC
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G
A
AMA
A
I
G
Y
A
RAT
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T
GV
--
C
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SGPG
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TN
L
ITGLA
D
A
LL
D
SI
P
VV
A
I
T
G
QVSAPF
IG
--
T
D
A
FQE
V
D
VL
--------
GLSLACT
K
HSF
LV
QSL
E
E
LP
RI
M
AE
A
FDV
A
S
S
-
GRPG
P
V
L
VD
I
P
K
D
I
QLASGDLE
---
PWFTTVENEV---
-
-TFPHA-E
V
EQ
A
RQM
L
AK
A
QK
P
M
L
YV
G
G
G
VGM
A
Q
A
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L
R
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P
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K
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Y
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L
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L
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M
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----
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R
DEHAWRYD--HPG
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----------------------------
A
-
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----
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T
T
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W
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-
IAHTR
P
E
NF
I
T
S
S
--------
GL
G
T
MG
F
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A
A
V
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R
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IS
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M
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T
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L
K
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LL
D
N
QR
LG
M
V
R
-
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L
FFQERYSETTLTDN
-----------
PD
F
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A
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G
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G
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AL
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---
DG
P
YL
L
HV
S
ID
EL
--------
E
NVW
P
L
V
PP
GA
S
N
S
EM
fig|444449.5.peg.3245
Escherichia coli O157:H7 str. EC4042 (7-543/548)
V
V
HA
L
RAQ
GV
NT
V
F
G
YP
G
GA
I
MP
V
Y
D
A
L
YDG
-
G
-
V
E
H
L
LC
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G
A
AMA
A
I
G
Y
A
RAT
GK
T
GV
--
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SGPG
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TN
L
ITGLA
D
A
LL
D
SI
P
VV
A
I
T
G
QVSAPF
IG
--
T
D
A
FQE
V
D
VL
--------
GLSLACT
K
HSF
LV
QSL
E
E
LP
RI
M
AE
A
FDV
A
S
S
-
GRPG
P
V
L
VD
I
P
K
D
I
QLASGDLE
---
PWFTTVENEV---
-
-TFPHA-E
V
EQ
A
RQM
L
AK
A
QK
P
M
L
YV
G
G
G
VGM
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Q
A
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L
R
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L
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----
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DEHAWRYD--HPG
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----------------------------
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-
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----
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W
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P
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NF
I
T
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S
--------
GL
G
T
MG
F
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A
A
V
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R
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M
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T
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L
K
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D
N
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LG
M
V
R
-
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L
FFQERYSETTLTDN
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F
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A
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G
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---
DG
P
YL
L
HV
S
ID
EL
--------
E
NVW
P
L
V
PP
GA
S
N
S
EM
fig|444448.5.peg.2000
Escherichia coli O157:H7 str. EC4045 (7-543/548)
V
V
HA
L
RAQ
GV
NT
V
F
G
YP
G
GA
I
MP
V
Y
D
A
L
YDG
-
G
-
V
E
H
L
LC
RHEQ
G
A
AMA
A
I
G
Y
A
RAT
GK
T
GV
--
C
IAT
SGPG
A
TN
L
ITGLA
D
A
LL
D
SI
P
VV
A
I
T
G
QVSAPF
IG
--
T
D
A
FQE
V
D
VL
--------
GLSLACT
K
HSF
LV
QSL
E
E
LP
RI
M
AE
A
FDV
A
S
S
-
GRPG
P
V
L
VD
I
P
K
D
I
QLASGDLE
---
PWFTTVENEV---
-
-TFPHA-E
V
EQ
A
RQM
L
AK
A
QK
P
M
L
YV
G
G
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A
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R
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L
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H
G
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L
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GD
----
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R
DEHAWRYD--HPG
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----------------------------
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-
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----
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T
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W
AA
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-
IAHTR
P
E
NF
I
T
S
S
--------
GL
G
T
MG
F
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A
A
V
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A
R
P
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IS
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M
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T
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L
K
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LL
D
N
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LG
M
V
R
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L
FFQERYSETTLTDN
-----------
PD
F
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LA
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A
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G
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G
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AL
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---
DG
P
YL
L
HV
S
ID
EL
--------
E
NVW
P
L
V
PP
GA
S
N
S
EM
fig|444453.5.peg.2141
Escherichia coli O157:H7 str. EC4076 (7-543/548)
V
V
HA
L
RAQ
GV
NT
V
F
G
YP
G
GA
I
MP
V
Y
D
A
L
YDG
-
G
-
V
E
H
L
LC
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G
A
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A
I
G
Y
A
RAT
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T
GV
--
C
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TN
L
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A
LL
D
SI
P
VV
A
I
T
G
QVSAPF
IG
--
T
D
A
FQE
V
D
VL
--------
GLSLACT
K
HSF
LV
QSL
E
E
LP
RI
M
AE
A
FDV
A
S
S
-
GRPG
P
V
L
VD
I
P
K
D
I
QLASGDLE
---
PWFTTVENEV---
-
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V
EQ
A
RQM
L
AK
A
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M
L
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G
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----
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----------------------------
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----
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W
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P
E
NF
I
T
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--------
GL
G
T
MG
F
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A
A
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LG
M
V
R
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---
DG
P
YL
L
HV
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ID
EL
--------
E
NVW
P
L
V
PP
GA
S
N
S
EM
fig|444452.5.peg.4616
Escherichia coli O157:H7 str. EC4113 (7-543/548)
V
V
HA
L
RAQ
GV
NT
V
F
G
YP
G
GA
I
MP
V
Y
D
A
L
YDG
-
G
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V
E
H
L
LC
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A
I
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Y
A
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T
GV
--
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TN
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LL
D
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P
VV
A
I
T
G
QVSAPF
IG
--
T
D
A
FQE
V
D
VL
--------
GLSLACT
K
HSF
LV
QSL
E
E
LP
RI
M
AE
A
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A
S
S
-
GRPG
P
V
L
VD
I
P
K
D
I
QLASGDLE
---
PWFTTVENEV---
-
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V
EQ
A
RQM
L
AK
A
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P
M
L
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G
G
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L
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----
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----
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W
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P
E
NF
I
T
S
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--------
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G
T
MG
F
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A
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M
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---
DG
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YL
L
HV
S
ID
EL
--------
E
NVW
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L
V
PP
GA
S
N
S
EM
fig|444450.8.peg.5082
Escherichia coli O157:H7 str. EC4115 (7-543/548)
V
V
HA
L
RAQ
GV
NT
V
F
G
YP
G
GA
I
MP
V
Y
D
A
L
YDG
-
G
-
V
E
H
L
LC
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G
A
AMA
A
I
G
Y
A
RAT
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T
GV
--
C
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A
TN
L
ITGLA
D
A
LL
D
SI
P
VV
A
I
T
G
QVSAPF
IG
--
T
D
A
FQE
V
D
VL
--------
GLSLACT
K
HSF
LV
QSL
E
E
LP
RI
M
AE
A
FDV
A
S
S
-
GRPG
P
V
L
VD
I
P
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D
I
QLASGDLE
---
PWFTTVENEV---
-
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V
EQ
A
RQM
L
AK
A
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P
M
L
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G
G
G
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A
Q
A
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R
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P
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L
K
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Y
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L
GM
H
G
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Q
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L
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IA
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M
DIDP
A
E
M
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L
Q
GD
----
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NA
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PA
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-
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R
DEHAWRYD--HPG
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----------------------------
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-
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SD
----
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T
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W
AA
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-
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P
E
NF
I
T
S
S
--------
GL
G
T
MG
F
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A
A
V
GA
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A
R
P
NDT
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IS
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SFM
M
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E
LG
T
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R
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LP
L
K
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LL
D
N
QR
LG
M
V
R
-
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L
FFQERYSETTLTDN
-----------
PD
F
LK
LA
S
A
F
G
IP
G
QH
I
TRKD
Q
VEA
AL
DTMLNS
---
DG
P
YL
L
HV
S
ID
EL
--------
E
NVW
P
L
V
PP
GA
S
N
S
EM
fig|444451.5.peg.3241
Escherichia coli O157:H7 str. EC4196 (7-543/548)
V
V
HA
L
RAQ
GV
NT
V
F
G
YP
G
GA
I
MP
V
Y
D
A
L
YDG
-
G
-
V
E
H
L
LC
RHEQ
G
A
AMA
A
I
G
Y
A
RAT
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T
GV
--
C
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SGPG
A
TN
L
ITGLA
D
A
LL
D
SI
P
VV
A
I
T
G
QVSAPF
IG
--
T
D
A
FQE
V
D
VL
--------
GLSLACT
K
HSF
LV
QSL
E
E
LP
RI
M
AE
A
FDV
A
S
S
-
GRPG
P
V
L
VD
I
P
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D
I
QLASGDLE
---
PWFTTVENEV---
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V
EQ
A
RQM
L
AK
A
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M
L
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G
G
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L
R
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P
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K
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AV
E
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GM
L
GM
H
G
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V
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EC
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L
L
IA
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R
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A
P
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H
A
SV
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M
DIDP
A
E
M
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L
Q
GD
----
L
NA
LL
PA
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Q-----Q
PL
N
-
I
ND
W
Q
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YCAQL
R
DEHAWRYD--HPG
D
----------------------------
A
-
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L
SD
----
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T
T
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W
AA
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-
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P
E
NF
I
T
S
S
--------
GL
G
T
MG
F
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A
A
V
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A
R
P
NDT
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IS
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M
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E
LG
T
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R
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LP
L
K
IV
LL
D
N
QR
LG
M
V
R
-
QWQQ
L
FFQERYSETTLTDN
-----------
PD
F
LK
LA
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A
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G
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G
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I
TRKD
Q
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AL
DTMLNS
---
DG
P
YL
L
HV
S
ID
EL
--------
E
NVW
P
L
V
PP
GA
S
N
S
EM
fig|444447.5.peg.2164
Escherichia coli O157:H7 str. EC4206 (7-543/548)
V
V
HA
L
RAQ
GV
NT
V
F
G
YP
G
GA
I
MP
V
Y
D
A
L
YDG
-
G
-
V
E
H
L
LC
RHEQ
G
A
AMA
A
I
G
Y
A
RAT
GK
T
GV
--
C
IAT
SGPG
A
TN
L
ITGLA
D
A
LL
D
SI
P
VV
A
I
T
G
QVSAPF
IG
--
T
D
A
FQE
V
D
VL
--------
GLSLACT
K
HSF
LV
QSL
E
E
LP
RI
M
AE
A
FDV
A
S
S
-
GRPG
P
V
L
VD
I
P
K
D
I
QLASGDLE
---
PWFTTVENEV---
-
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V
EQ
A
RQM
L
AK
A
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P
M
L
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G
G
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A
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P
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H
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V
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M
NKLRQAH
VA
L
Q
GD
----
L
NA
LL
PA
L
Q-----Q
PL
N
-
I
ND
W
Q
Q
YCAQL
R
DEHAWRYD--HPG
D
----------------------------
A
-
IYAPLLLKQ
L
SD
----
RKPADCVV
T
T
DVG
QH
QM
W
AA
QH
-
IAHTR
P
E
NF
I
T
S
S
--------
GL
G
T
MG
F
GLP
A
A
V
GA
QV
A
R
P
NDT
VVC
IS
GDG
SFM
M
NVQ
E
LG
T
VK
R
KQ
LP
L
K
IV
LL
D
N
QR
LG
M
V
R
-
QWQQ
L
FFQERYSETTLTDN
-----------
PD
F
LK
LA
S
A
F
G
IP
G
QH
I
TRKD
Q
VEA
AL
DTMLNS
---
DG
P
YL
L
HV
S
ID
EL
--------
E
NVW
P
L
V
PP
GA
S
N
S
EM
fig|478004.5.peg.557
Escherichia coli O157:H7 str. EC4401 (7-543/548)
V
V
HA
L
RAQ
GV
NT
V
F
G
YP
G
GA
I
MP
V
Y
D
A
L
YDG
-
G
-
V
E
H
L
LC
RHEQ
G
A
AMA
A
I
G
Y
A
RAT
GK
T
GV
--
C
IAT
SGPG
A
TN
L
ITGLA
D
A
LL
D
SI
P
VV
A
I
T
G
QVSAPF
IG
--
T
D
A
FQE
V
D
VL
--------
GLSLACT
K
HSF
LV
QSL
E
E
LP
RI
M
AE
A
FDV
A
S
S
-
GRPG
P
V
L
VD
I
P
K
D
I
QLASGDLE
---
PWFTTVENEV---
-
-TFPHA-E
V
EQ
A
RQM
L
AK
A
QK
P
M
L
YV
G
G
G
VGM
A
Q
A
VPA
L
R
E
FLATTKM
P
ATCT
L
K
GLG
AV
E
AD
Y
P
YYL
GM
L
GM
H
G
TKAANFA
V
Q
EC
D
L
L
IA
VG
A
RF
DD
R
VTGKLNT
F
A
P
-
H
A
SV
IH
M
DIDP
A
E
M
NKLRQAH
VA
L
Q
GD
----
L
NA
LL
PA
L
Q-----Q
PL
N
-
I
ND
W
Q
Q
YCAQL
R
DEHAWRYD--HPG
D
----------------------------
A
-
IYAPLLLKQ
L
SD
----
RKPADCVV
T
T
DVG
QH
QM
W
AA
QH
-
IAHTR
P
E
NF
I
T
S
S
--------
GL
G
T
MG
F
GLP
A
A
V
GA
QV
A
R
P
NDT
VVC
IS
GDG
SFM
M
NVQ
E
LG
T
VK
R
KQ
LP
L
K
IV
LL
D
N
QR
LG
M
V
R
-
QWQQ
L
FFQERYSETTLTDN
-----------
PD
F
LK
LA
S
A
F
G
IP
G
QH
I
TRKD
Q
VEA
AL
DTMLNS
---
DG
P
YL
L
HV
S
ID
EL
--------
E
NVW
P
L
V
PP
GA
S
N
S
EM
fig|478005.5.peg.2069
Escherichia coli O157:H7 str. EC4486 (7-543/548)
V
V
HA
L
RAQ
GV
NT
V
F
G
YP
G
GA
I
MP
V
Y
D
A
L
YDG
-
G
-
V
E
H
L
LC
RHEQ
G
A
AMA
A
I
G
Y
A
RAT
GK
T
GV
--
C
IAT
SGPG
A
TN
L
ITGLA
D
A
LL
D
SI
P
VV
A
I
T
G
QVSAPF
IG
--
T
D
A
FQE
V
D
VL
--------
GLSLACT
K
HSF
LV
QSL
E
E
LP
RI
M
AE
A
FDV
A
S
S
-
GRPG
P
V
L
VD
I
P
K
D
I
QLASGDLE
---
PWFTTVENEV---
-
-TFPHA-E
V
EQ
A
RQM
L
AK
A
QK
P
M
L
YV
G
G
G
VGM
A
Q
A
VPA
L
R
E
FLATTKM
P
ATCT
L
K
GLG
AV
E
AD
Y
P
YYL
GM
L
GM
H
G
TKAANFA
V
Q
EC
D
L
L
IA
VG
A
RF
DD
R
VTGKLNT
F
A
P
-
H
A
SV
IH
M
DIDP
A
E
M
NKLRQAH
VA
L
Q
GD
----
L
NA
LL
PA
L
Q-----Q
PL
N
-
I
ND
W
Q
Q
YCAQL
R
DEHAWRYD--HPG
D
----------------------------
A
-
IYAPLLLKQ
L
SD
----
RKPADCVV
T
T
DVG
QH
QM
W
AA
QH
-
IAHTR
P
E
NF
I
T
S
S
--------
GL
G
T
MG
F
GLP
A
A
V
GA
QV
A
R
P
NDT
VVC
IS
GDG
SFM
M
NVQ
E
LG
T
VK
R
KQ
LP
L
K
IV
LL
D
N
QR
LG
M
V
R
-
QWQQ
L
FFQERYSETTLTDN
-----------
PD
F
LK
LA
S
A
F
G
IP
G
QH
I
TRKD
Q
VEA
AL
DTMLNS
---
DG
P
YL
L
HV
S
ID
EL
--------
E
NVW
P
L
V
PP
GA
S
N
S
EM
fig|478006.5.peg.4494
Escherichia coli O157:H7 str. EC4501 (7-543/548)
V
V
HA
L
RAQ
GV
NT
V
F
G
YP
G
GA
I
MP
V
Y
D
A
L
YDG
-
G
-
V
E
H
L
LC
RHEQ
G
A
AMA
A
I
G
Y
A
RAT
GK
T
GV
--
C
IAT
SGPG
A
TN
L
ITGLA
D
A
LL
D
SI
P
VV
A
I
T
G
QVSAPF
IG
--
T
D
A
FQE
V
D
VL
--------
GLSLACT
K
HSF
LV
QSL
E
E
LP
RI
M
AE
A
FDV
A
S
S
-
GRPG
P
V
L
VD
I
P
K
D
I
QLASGDLE
---
PWFTTVENEV---
-
-TFPHA-E
V
EQ
A
RQM
L
AK
A
QK
P
M
L
YV
G
G
G
VGM
A
Q
A
VPA
L
R
E
FLATTKM
P
ATCT
L
K
GLG
AV
E
AD
Y
P
YYL
GM
L
GM
H
G
TKAANFA
V
Q
EC
D
L
L
IA
VG
A
RF
DD
R
VTGKLNT
F
A
P
-
H
A
SV
IH
M
DIDP
A
E
M
NKLRQAH
VA
L
Q
GD
----
L
NA
LL
PA
L
Q-----Q
PL
N
-
I
ND
W
Q
Q
YCAQL
R
DEHAWRYD--HPG
D
----------------------------
A
-
IYAPLLLKQ
L
SD
----
RKPADCVV
T
T
DVG
QH
QM
W
AA
QH
-
IAHTR
P
E
NF
I
T
S
S
--------
GL
G
T
MG
F
GLP
A
A
V
GA
QV
A
R
P
NDT
VVC
IS
GDG
SFM
M
NVQ
E
LG
T
VK
R
KQ
LP
L
K
IV
LL
D
N
QR
LG
M
V
R
-
QWQQ
L
FFQERYSETTLTDN
-----------
PD
F
LK
LA
S
A
F
G
IP
G
QH
I
TRKD
Q
VEA
AL
DTMLNS
---
DG
P
YL
L
HV
S
ID
EL
--------
E
NVW
P
L
V
PP
GA
S
N
S
EM
fig|478007.5.peg.3635
Escherichia coli O157:H7 str. EC508 (7-543/548)
V
V
HA
L
RAQ
GV
NT
V
F
G
YP
G
GA
I
MP
V
Y
D
A
L
YDG
-
G
-
V
E
H
L
LC
RHEQ
G
A
AMA
A
I
G
Y
A
RAT
GK
T
GV
--
C
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SGPG
A
TN
L
ITGLA
D
A
LL
D
SI
P
VV
A
I
T
G
QVSAPF
IG
--
T
D
A
FQE
V
D
VL
--------
GLSLACT
K
HSF
LV
QSL
E
E
LP
RI
M
AE
A
FDV
A
S
S
-
GRPG
P
V
L
VD
I
P
K
D
I
QLASGDLE
---
PWFTTVENEV---
-
-TFPHA-E
V
EQ
A
RQM
L
AK
A
QK
P
M
L
YV
G
G
G
VGM
A
Q
A
VPA
L
R
E
FLATTKM
P
ATCT
L
K
GLG
AV
E
AD
Y
P
YYL
GM
L
GM
H
G
TKAANFA
V
Q
EC
D
L
L
IA
VG
A
RF
DD
R
VTGKLNT
F
A
P
-
H
A
SV
IH
M
DIDP
A
E
M
NKLRQAH
VA
L
Q
GD
----
L
NA
LL
PA
L
Q-----Q
PL
N
-
I
ND
W
Q
Q
YCAQL
R
DEHAWRYD--HPG
D
----------------------------
A
-
IYAPLLLKQ
L
SD
----
RKPADCVV
T
T
DVG
QH
QM
W
AA
QH
-
IAHTR
P
E
NF
I
T
S
S
--------
GL
G
T
MG
F
GLP
A
A
V
GA
QV
A
R
P
NDT
VVC
IS
GDG
SFM
M
NVQ
E
LG
T
VK
R
KQ
LP
L
K
IV
LL
D
N
QR
LG
M
V
R
-
QWQQ
L
FFQERYSETTLTDN
-----------
PD
F
LK
LA
S
A
F
G
IP
G
QH
I
TRKD
Q
VEA
AL
DTMLNS
---
DG
P
YL
L
HV
S
ID
EL
--------
E
NVW
P
L
V
PP
GA
S
N
S
EM
fig|478008.5.peg.1883
Escherichia coli O157:H7 str. EC869 (7-543/548)
V
V
HA
L
RAQ
GV
NT
V
F
G
YP
G
GA
I
MP
V
Y
D
A
L
YDG
-
G
-
V
E
H
L
LC
RHEQ
G
A
AMA
A
I
G
Y
A
RAT
GK
T
GV
--
C
IAT
SGPG
A
TN
L
ITGLA
D
A
LL
D
SI
P
VV
A
I
T
G
QVSAPF
IG
--
T
D
A
FQE
V
D
VL
--------
GLSLACT
K
HSF
LV
QSL
E
E
LP
RI
M
AE
A
FDV
A
S
S
-
GRPG
P
V
L
VD
I
P
K
D
I
QLASGDLE
---
PWFTTVENEV---
-
-TFPHA-E
V
EQ
A
RQM
L
AK
A
QK
P
M
L
YV
G
G
G
VGM
A
Q
A
VPA
L
R
E
FLATTKM
P
ATCT
L
K
GLG
AV
E
AD
Y
P
YYL
GM
L
GM
H
G
TKAANFA
V
Q
EC
D
L
L
IA
VG
A
RF
DD
R
VTGKLNT
F
A
P
-
H
A
SV
IH
M
DIDP
A
E
M
NKLRQAH
VA
L
Q
GD
----
L
NA
LL
PA
L
Q-----Q
PL
N
-
I
ND
W
Q
Q
YCAQL
R
DEHAWRYD--HPG
D
----------------------------
A
-
IYAPLLLKQ
L
SD
----
RKPADCVV
T
T
DVG
QH
QM
W
AA
QH
-
IAHTR
P
E
NF
I
T
S
S
--------
GL
G
T
MG
F
GLP
A
A
V
GA
QV
A
R
P
NDT
VVC
IS
GDG
SFM
M
NVQ
E
LG
T
VK
R
KQ
LP
L
K
IV
LL
D
N
QR
LG
M
V
R
-
QWQQ
L
FFQERYSETTLTDN
-----------
PD
F
LK
LA
S
A
F
G
IP
G
QH
I
TRKD
Q
VEA
AL
DTMLNS
---
DG
P
YL
L
HV
S
ID
EL
--------
E
NVW
P
L
V
PP
GA
S
N
S
EM
fig|637388.3.peg.2667
Escherichia coli O157:H7 str. FRIK2000 (7-543/548)
V
V
HA
L
RAQ
GV
NT
V
F
G
YP
G
GA
I
MP
V
Y
D
A
L
YDG
-
G
-
V
E
H
L
LC
RHEQ
G
A
AMA
A
I
G
Y
A
RAT
GK
T
GV
--
C
IAT
SGPG
A
TN
L
ITGLA
D
A
LL
D
SI
P
VV
A
I
T
G
QVSAPF
IG
--
T
D
A
FQE
V
D
VL
--------
GLSLACT
K
HSF
LV
QSL
E
E
LP
RI
M
AE
A
FDV
A
S
S
-
GRPG
P
V
L
VD
I
P
K
D
I
QLASGDLE
---
PWFTTVENEV---
-
-TFPHA-E
V
EQ
A
RQM
L
AK
A
QK
P
M
L
YV
G
G
G
VGM
A
Q
A
VPA
L
R
E
FLATTKM
P
ATCT
L
K
GLG
AV
E
AD
Y
P
YYL
GM
L
GM
H
G
TKAANFA
V
Q
EC
D
L
L
IA
VG
A
RF
DD
R
VTGKLNT
F
A
P
-
H
A
SV
IH
M
DIDP
A
E
M
NKLRQAH
VA
L
Q
GD
----
L
NA
LL
PA
L
Q-----Q
PL
N
-
I
ND
W
Q
Q
YCAQL
R
DEHAWRYD--HPG
D
----------------------------
A
-
IYAPLLLKQ
L
SD
----
RKPADCVV
T
T
DVG
QH
QM
W
AA
QH
-
IAHTR
P
E
NF
I
T
S
S
--------
GL
G
T
MG
F
GLP
A
A
V
GA
QV
A
R
P
NDT
VVC
IS
GDG
SFM
M
NVQ
E
LG
T
VK
R
KQ
LP
L
K
IV
LL
D
N
QR
LG
M
V
R
-
QWQQ
L
FFQERYSETTLTDN
-----------
PD
F
LK
LA
S
A
F
G
IP
G
QH
I
TRKD
Q
VEA
AL
DTMLNS
---
DG
P
YL
L
HV
S
ID
EL
--------
E
NVW
P
L
V
PP
GA
S
N
S
EM
fig|570506.3.peg.1448
Escherichia coli O157:H7 str. FRIK966 (7-543/548)
V
V
HA
L
RAQ
GV
NT
V
F
G
YP
G
GA
I
MP
V
Y
D
A
L
YDG
-
G
-
V
E
H
L
LC
RHEQ
G
A
AMA
A
I
G
Y
A
RAT
GK
T
GV
--
C
IAT
SGPG
A
TN
L
ITGLA
D
A
LL
D
SI
P
VV
A
I
T
G
QVSAPF
IG
--
T
D
A
FQE
V
D
VL
--------
GLSLACT
K
HSF
LV
QSL
E
E
LP
RI
M
AE
A
FDV
A
S
S
-
GRPG
P
V
L
VD
I
P
K
D
I
QLASGDLE
---
PWFTTVENEV---
-
-TFPHA-E
V
EQ
A
RQM
L
AK
A
QK
P
M
L
YV
G
G
G
VGM
A
Q
A
VPA
L
R
E
FLATTKM
P
ATCT
L
K
GLG
AV
E
AD
Y
P
YYL
GM
L
GM
H
G
TKAANFA
V
Q
EC
D
L
L
IA
VG
A
RF
DD
R
VTGKLNT
F
A
P
-
H
A
SV
IH
M
DIDP
A
E
M
NKLRQAH
VA
L
Q
GD
----
L
NA
LL
PA
L
Q-----Q
PL
N
-
I
ND
W
Q
Q
YCAQL
R
DEHAWRYD--HPG
D
----------------------------
A
-
IYAPLLLKQ
L
SD
----
RKPADCVV
T
T
DVG
QH
QM
W
AA
QH
-
IAHTR
P
E
NF
I
T
S
S
--------
GL
G
T
MG
F
GLP
A
A
V
GA
QV
A
R
P
NDT
VVC
IS
GDG
SFM
M
NVQ
E
LG
T
VK
R
KQ
LP
L
K
IV
LL
D
N
QR
LG
M
V
R
-
QWQQ
L
FFQERYSETTLTDN
-----------
PD
F
LK
LA
S
A
F
G
IP
G
QH
I
TRKD
Q
VEA
AL
DTMLNS
---
DG
P
YL
L
HV
S
ID
EL
--------
E
NVW
P
L
V
PP
GA
S
N
S
EM
fig|386585.9.peg.4907
Escherichia coli O157:H7 str. Sakai (7-543/548)
V
V
HA
L
RAQ
GV
NT
V
F
G
YP
G
GA
I
MP
V
Y
D
A
L
YDG
-
G
-
V
E
H
L
LC
RHEQ
G
A
AMA
A
I
G
Y
A
RAT
GK
T
GV
--
C
IAT
SGPG
A
TN
L
ITGLA
D
A
LL
D
SI
P
VV
A
I
T
G
QVSAPF
IG
--
T
D
A
FQE
V
D
VL
--------
GLSLACT
K
HSF
LV
QSL
E
E
LP
RI
M
AE
A
FDV
A
S
S
-
GRPG
P
V
L
VD
I
P
K
D
I
QLASGDLE
---
PWFTTVENEV---
-
-TFPHA-E
V
EQ
A
RQM
L
AK
A
QK
P
M
L
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G
G
G
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Q
A
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L
R
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L
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GM
L
GM
H
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V
Q
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L
IA
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A
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H
A
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M
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A
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M
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L
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GD
----
L
NA
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L
Q-----Q
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N
-
I
ND
W
Q
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YCAQL
R
DEHAWRYD--HPG
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----------------------------
A
-
IYAPLLLKQ
L
SD
----
RKPADCVV
T
T
DVG
QH
QM
W
AA
QH
-
IAHTR
P
E
NF
I
T
S
S
--------
GL
G
T
MG
F
GLP
A
A
V
GA
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A
R
P
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IS
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M
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E
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T
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R
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LP
L
K
IV
LL
D
N
QR
LG
M
V
R
-
QWQQ
L
FFQERYSETTLTDN
-----------
PD
F
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S
A
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G
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G
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I
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AL
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---
DG
P
YL
L
HV
S
ID
EL
--------
E
NVW
P
L
V
PP
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S
N
S
EM
fig|502346.5.peg.1915
Escherichia coli O157:H7 str. TW14588 (7-543/548)
V
V
HA
L
RAQ
GV
NT
V
F
G
YP
G
GA
I
MP
V
Y
D
A
L
YDG
-
G
-
V
E
H
L
LC
RHEQ
G
A
AMA
A
I
G
Y
A
RAT
GK
T
GV
--
C
IAT
SGPG
A
TN
L
ITGLA
D
A
LL
D
SI
P
VV
A
I
T
G
QVSAPF
IG
--
T
D
A
FQE
V
D
VL
--------
GLSLACT
K
HSF
LV
QSL
E
E
LP
RI
M
AE
A
FDV
A
S
S
-
GRPG
P
V
L
VD
I
P
K
D
I
QLASGDLE
---
PWFTTVENEV---
-
-TFPHA-E
V
EQ
A
RQM
L
AK
A
QK
P
M
L
YV
G
G
G
VGM
A
Q
A
VPA
L
R
E
FLATTKM
P
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L
K
GLG
AV
E
AD
Y
P
YYL
GM
L
GM
H
G
TKAANFA
V
Q
EC
D
L
L
IA
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A
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R
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P
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H
A
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M
DIDP
A
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M
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L
Q
GD
----
L
NA
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PA
L
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N
-
I
ND
W
Q
Q
YCAQL
R
DEHAWRYD--HPG
D
----------------------------
A
-
IYAPLLLKQ
L
SD
----
RKPADCVV
T
T
DVG
QH
QM
W
AA
QH
-
IAHTR
P
E
NF
I
T
S
S
--------
GL
G
T
MG
F
GLP
A
A
V
GA
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A
R
P
NDT
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IS
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M
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E
LG
T
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R
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LP
L
K
IV
LL
D
N
QR
LG
M
V
R
-
QWQQ
L
FFQERYSETTLTDN
-----------
PD
F
LK
LA
S
A
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G
IP
G
QH
I
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VEA
AL
DTMLNS
---
DG
P
YL
L
HV
S
ID
EL
--------
E
NVW
P
L
V
PP
GA
S
N
S
EM
fig|701177.3.peg.4576
Escherichia coli O55:H7 str. CB9615 (7-543/548)
V
V
HA
L
RAQ
GV
NT
V
F
G
YP
G
GA
I
MP
V
Y
D
A
L
YDG
-
G
-
V
E
H
L
LC
RHEQ
G
A
AMA
A
I
G
Y
A
RAT
GK
T
GV
--
C
IAT
SGPG
A
TN
L
ITGLA
D
A
LL
D
SI
P
VV
A
I
T
G
QVSAPF
IG
--
T
D
A
FQE
V
D
VL
--------
GLSLACT
K
HSF
LV
QSL
E
E
LP
RI
M
AE
A
FDV
A
S
S
-
GRPG
P
V
L
VD
I
P
K
D
I
QLASGDLE
---
PWFTTVENEV---
-
-TFPHA-E
V
EQ
A
RQM
L
AK
A
QK
P
M
L
YV
G
G
G
VGM
A
Q
A
VPA
L
R
E
FLATTKM
P
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L
K
GLG
AV
E
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Y
P
YYL
GM
L
GM
H
G
TKAANFA
V
Q
EC
D
L
L
IA
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A
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DD
R
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F
A
P
-
H
A
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IH
M
DIDP
A
E
M
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L
Q
GD
----
L
NA
LL
PA
L
Q-----Q
PL
N
-
I
ND
W
Q
Q
YCAQL
R
DEHAWRYD--HPG
D
----------------------------
A
-
IYAPLLLKQ
L
SD
----
RKPADCVV
T
T
DVG
QH
QM
W
AA
QH
-
IAHTR
P
E
NF
I
T
S
S
--------
GL
G
T
MG
F
GLP
A
A
V
GA
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A
R
P
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M
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LG
T
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LP
L
K
IV
LL
D
N
QR
LG
M
V
R
-
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L
FFQERYSETTLTDN
-----------
PD
F
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LA
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A
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G
IP
G
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I
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AL
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---
DG
P
YL
L
HV
S
ID
EL
--------
E
NVW
P
L
V
PP
GA
S
N
S
EM
fig|656414.3.peg.4298
Escherichia coli H736 (7-543/548)
V
V
HA
L
RAQ
GV
NT
V
F
G
YP
G
GA
I
MP
V
Y
D
A
L
YDG
-
G
-
V
E
H
L
LC
RHEQ
G
A
AMA
A
I
G
Y
A
RAT
GK
T
GV
--
C
IAT
SGPG
A
TN
L
ITGLA
D
A
LL
D
SI
P
VV
A
I
T
G
QVSAPF
IG
--
T
D
A
FQE
V
D
VL
--------
GLSLACT
K
HSF
LV
QSL
E
E
LP
RI
M
AE
A
FDV
A
C
S
-
GRPG
P
V
L
VD
I
P
K
D
I
QLASGDLE
---
PWFTTVENEV---
-
-TFPHA-E
V
EQ
A
RQM
L
AK
A
QK
P
M
L
YV
G
G
G
VGM
A
Q
A
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L
R
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K
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AD
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GM
L
GM
H
G
TKAANFA
V
Q
EC
D
L
L
IA
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A
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A
P
-
H
A
SV
IH
M
DIDP
A
E
M
NKLRQAH
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L
Q
GD
----
L
NA
LL
PA
L
Q-----Q
PL
N
-
I
ND
W
Q
Q
HCAQL
R
DEHSWRYD--HPG
D
----------------------------
A
-
IYAPLLLKQ
L
SD
----
RKPADCVV
T
T
DVG
QH
QM
W
AA
QH
-
IAHTR
P
E
NF
I
T
S
S
--------
GL
G
T
MG
F
GLP
A
A
V
GA
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A
R
P
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M
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T
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LP
L
K
IV
LL
D
N
QR
LG
M
V
R
-
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L
FFQERYSETTLTDN
-----------
PD
F
LM
LA
S
A
F
G
IH
G
QH
I
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AL
DTMLNS
---
DG
P
YL
L
HV
S
ID
EL
--------
E
NVW
P
L
V
PP
GA
S
N
S
EM
fig|749538.3.peg.931
Escherichia coli MS 116-1 (7-543/548)
V
V
HA
L
RAQ
GV
NT
V
F
G
YP
G
GA
I
MP
V
Y
D
A
L
YDG
-
G
-
V
E
H
L
LC
RHEQ
G
A
AMA
A
I
G
Y
A
RAT
GK
T
GV
--
C
IAT
SGPG
A
TN
L
ITGLA
D
A
LL
D
SI
P
VV
A
I
T
G
QVSAPF
IG
--
T
D
A
FQE
V
D
VL
--------
GLSLACT
K
HSF
LV
QSL
E
E
LP
RI
M
AE
A
FDV
A
C
S
-
GRPG
P
V
L
VD
I
P
K
D
I
QLASGDLE
---
PWFTTVENEV---
-
-TFPHA-E
V
EQ
A
RQM
L
AK
A
QK
P
M
L
YV
G
G
G
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A
Q
A
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L
R
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P
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K
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AV
E
AD
Y
P
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GM
L
GM
H
G
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V
Q
EC
D
L
L
IA
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A
P
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H
A
SV
IH
M
DIDP
A
E
M
NKLRQAH
VA
L
Q
GD
----
L
NA
LL
PA
L
Q-----Q
PL
N
-
I
ND
W
Q
Q
HCAQL
R
DEHSWRYD--HPG
D
----------------------------
A
-
IYAPLLLKQ
L
SD
----
RKPADCVV
T
T
DVG
QH
QM
W
AA
QH
-
IAHTR
P
E
NF
I
T
S
S
--------
GL
G
T
MG
F
GLP
A
A
V
GA
QV
A
R
P
NDT
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IS
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M
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E
LG
T
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R
KQ
LP
L
K
IV
LL
D
N
QR
LG
M
V
R
-
QWQQ
L
FFQERYSETTLTDN
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PD
F
LM
LA
S
A
F
G
IH
G
QH
I
TRKD
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VEA
AL
DTMLNS
---
DG
P
YL
L
HV
S
ID
EL
--------
E
NVW
P
L
V
PP
GA
S
N
S
EM
fig|749540.3.peg.2651
Escherichia coli MS 146-1 (7-543/548)
V
V
HA
L
RAQ
GV
NT
V
F
G
YP
G
GA
I
MP
V
Y
D
A
L
YDG
-
G
-
V
E
H
L
LC
RHEQ
G
A
AMA
A
I
G
Y
A
RAT
GK
T
GV
--
C
IAT
SGPG
A
TN
L
ITGLA
D
A
LL
D
SI
P
VV
A
I
T
G
QVSAPF
IG
--
T
D
A
FQE
V
D
VL
--------
GLSLACT
K
HSF
LV
QSL
E
E
LP
RI
M
AE
A
FDV
A
C
S
-
GRPG
P
V
L
VD
I
P
K
D
I
QLASGDLE
---
PWFTTVENEV---
-
-TFPHA-E
V
EQ
A
RQM
L
AK
A
QK
P
M
L
YV
G
G
G
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A
Q
A
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L
R
E
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P
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L
K
GLG
AV
E
AD
Y
P
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GM
L
GM
H
G
TKAANFA
V
Q
EC
D
L
L
IA
VG
A
RF
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R
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F
A
P
-
H
A
SV
IH
M
DIDP
A
E
M
NKLRQAH
VA
L
Q
GD
----
L
NA
LL
PA
L
Q-----Q
PL
N
-
I
ND
W
Q
Q
HCAQL
R
DEHSWRYD--HPG
D
----------------------------
A
-
IYAPLLLKQ
L
SD
----
RKPADCVV
T
T
DVG
QH
QM
W
AA
QH
-
IAHTR
P
E
NF
I
T
S
S
--------
GL
G
T
MG
F
GLP
A
A
V
GA
QV
A
R
P
NDT
VVC
IS
GDG
SFM
M
NVQ
E
LG
T
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R
KQ
LP
L
K
IV
LL
D
N
QR
LG
M
V
R
-
QWQQ
L
FFQERYSETTLTDN
-----------
PD
F
LM
LA
S
A
F
G
IH
G
QH
I
TRKD
Q
VEA
AL
DTMLNS
---
DG
P
YL
L
HV
S
ID
EL
--------
E
NVW
P
L
V
PP
GA
S
N
S
EM
fig|749544.3.peg.1078
Escherichia coli MS 175-1 (7-543/548)
V
V
HA
L
RAQ
GV
NT
V
F
G
YP
G
GA
I
MP
V
Y
D
A
L
YDG
-
G
-
V
E
H
L
LC
RHEQ
G
A
AMA
A
I
G
Y
A
RAT
GK
T
GV
--
C
IAT
SGPG
A
TN
L
ITGLA
D
A
LL
D
SI
P
VV
A
I
T
G
QVSAPF
IG
--
T
D
A
FQE
V
D
VL
--------
GLSLACT
K
HSF
LV
QSL
E
E
LP
RI
M
AE
A
FDV
A
C
S
-
GRPG
P
V
L
VD
I
P
K
D
I
QLASGDLE
---
PWFTTVENEV---
-
-TFPHA-E
V
EQ
A
RQM
L
AK
A
QK
P
M
L
YV
G
G
G
VGM
A
Q
A
VPA
L
R
E
FLAATKM
P
ATCT
L
K
GLG
AV
E
AD
Y
P
YYL
GM
L
GM
H
G
TKAANFA
V
Q
EC
D
L
L
IA
VG
A
RF
DD
R
VTGKLNT
F
A
P
-
H
A
SV
IH
M
DIDP
A
E
M
NKLRQAH
VA
L
Q
GD
----
L
NA
LL
PA
L
Q-----Q
PL
N
-
I
ND
W
Q
Q
HCAQL
R
DEHSWRYD--HPG
D
----------------------------
A
-
IYAPLLLKQ
L
SD
----
RKPADCVV
T
T
DVG
QH
QM
W
AA
QH
-
IAHTR
P
E
NF
I
T
S
S
--------
GL
G
T
MG
F
GLP
A
A
V
GA
QV
A
R
P
NDT
VVC
IS
GDG
SFM
M
NVQ
E
LG
T
VK
R
KQ
LP
L
K
IV
LL
D
N
QR
LG
M
V
R
-
QWQQ
L
FFQERYSETTLTDN
-----------
PD
F
LM
LA
S
A
F
G
IH
G
QH
I
TRKD
Q
VEA
AL
DTMLNS
---
DG
P
YL
L
HV
S
ID
EL
--------
E
NVW
P
L
V
PP
GA
S
N
S
EM
fig|749548.3.peg.4575
Escherichia coli MS 196-1 (7-543/548)
V
V
HA
L
RAQ
GV
NT
V
F
G
YP
G
GA
I
MP
V
Y
D
A
L
YDG
-
G
-
V
E
H
L
LC
RHEQ
G
A
AMA
A
I
G
Y
A
RAT
GK
T
GV
--
C
IAT
SGPG
A
TN
L
ITGLA
D
A
LL
D
SI
P
VV
A
I
T
G
QVSAPF
IG
--
T
D
A
FQE
V
D
VL
--------
GLSLACT
K
HSF
LV
QSL
E
E
LP
RI
M
AE
A
FDV
A
C
S
-
GRPG
P
V
L
VD
I
P
K
D
I
QLASGDLE
---
PWFTTVENEV---
-
-TFPHA-E
V
EQ
A
RQM
L
AK
A
QK
P
M
L
YV
G
G
G
VGM
A
Q
A
VPA
L
R
E
FLAATKM
P
ATCT
L
K
GLG
AV
E
AD
Y
P
YYL
GM
L
GM
H
G
TKAANFA
V
Q
EC
D
L
L
IA
VG
A
RF
DD
R
VTGKLNT
F
A
P
-
H
A
SV
IH
M
DIDP
A
E
M
NKLRQAH
VA
L
Q
GD
----
L
NA
LL
PA
L
Q-----Q
PL
N
-
I
ND
W
Q
Q
HCAQL
R
DEHSWRYD--HPG
D
----------------------------
A
-
IYAPLLLKQ
L
SD
----
RKPADCVV
T
T
DVG
QH
QM
W
AA
QH
-
IAHTR
P
E
NF
I
T
S
S
--------
GL
G
T
MG
F
GLP
A
A
V
GA
QV
A
R
P
NDT
VVC
IS
GDG
SFM
M
NVQ
E
LG
T
VK
R
KQ
LP
L
K
IV
LL
D
N
QR
LG
M
V
R
-
QWQQ
L
FFQERYSETTLTDN
-----------
PD
F
LM
LA
S
A
F
G
IH
G
QH
I
TRKD
Q
VEA
AL
DTMLNS
---
DG
P
YL
L
HV
S
ID
EL
--------
E
NVW
P
L
V
PP
GA
S
N
S
EM
fig|670888.3.peg.2458
Escherichia coli 1827-70 (7-543/548)
V
V
HA
L
RAQ
GV
NT
V
F
G
YP
G
GA
I
MP
V
Y
D
A
L
YDG
-
G
-
V
E
H
L
LC
RHEQ
G
A
AMA
A
I
G
Y
A
RAT
GK
T
GV
--
C
IAT
SGPG
A
TN
L
ITGLA
D
A
LL
D
SI
P
VV
A
I
T
G
QVSAPF
IG
--
T
D
A
FQE
V
D
VL
--------
GLSLACT
K
HSF
LV
QSL
E
E
LP
RI
M
AE
A
FDV
A
S
S
-
GRPG
P
V
L
VD
I
P
K
D
I
QLASGDLE
---
PWFTTVENEV---
-
-TFPHA-E
V
EQ
A
RQM
L
AK
A
QK
P
M
L
YV
G
G
G
VGM
A
Q
A
VPA
L
R
E
FLATTKM
P
ATCT
L
K
GLG
AV
E
AD
Y
P
YYL
GM
L
GM
H
G
TKAANFA
V
Q
EC
D
L
L
IA
VG
A
RF
DD
R
VTGKLNT
F
A
P
-
H
A
SV
IH
M
DIDP
A
E
M
NKLRQAH
VA
L
Q
GD
----
L
NA
LL
PA
L
Q-----Q
PL
N
-
I
ND
W
Q
Q
HCAQL
R
DEHAWRYD--HPG
D
----------------------------
A
-
IYAPLLLKQ
L
SD
----
RKPADCVV
T
T
DVG
QH
QM
W
AA
QH
-
IAHTR
P
E
NF
I
T
S
S
--------
GL
G
T
MG
F
GLP
A
A
V
GA
QV
A
R
P
NDT
VVC
IS
GDG
SFM
M
NVQ
E
LG
T
VK
R
KQ
LP
L
K
IV
LL
D
N
QR
LG
M
V
R
-
QWQQ
L
FFQERYSETTLTDN
-----------
PD
F
LM
LA
S
A
F
G
IP
G
QH
I
TRKD
Q
VEA
AL
NTMLNS
---
DG
P
YL
L
HV
S
ID
EL
--------
E
NVW
P
L
V
PP
GA
S
N
S
EM
fig|344610.3.peg.3487
Escherichia coli 53638 (7-543/548)
V
V
HA
L
RAQ
GV
NT
V
F
G
YP
G
GA
I
MP
V
Y
D
A
L
YDG
-
G
-
V
E
H
L
LC
RHEQ
G
A
AMA
A
I
G
Y
A
RAT
GK
T
GV
--
C
IAT
SGPG
A
TN
L
ITGLA
D
A
LL
D
SI
P
VV
A
I
T
G
QVSAPF
IG
--
T
D
A
FQE
V
D
VL
--------
GLSLACT
K
HSF
LV
QSL
E
E
LP
RI
M
AE
A
FDV
A
S
S
-
GRPG
P
V
L
VD
I
P
K
D
I
QLASGDLE
---
PWFTTVENEV---
-
-TFPHA-E
V
EQ
A
RQM
L
AK
A
QK
P
M
L
YV
G
G
G
VGM
A
Q
A
VPA
L
R
E
FLATTKM
P
ATCT
L
K
GLG
AV
E
AD
Y
P
YYL
GM
L
GM
H
G
TKAANFA
V
Q
EC
D
L
L
IA
VG
A
RF
DD
R
VTGKLNT
F
A
P
-
H
A
SV
IH
M
DIDP
A
E
M
NKLRQAH
VA
L
Q
GD
----
L
NA
LL
PA
L
Q-----Q
PL
N
-
I
ND
W
Q
Q
HCAQL
R
DEHAWRYD--HPG
D
----------------------------
A
-
IYAPLLLKQ
L
SD
----
RKPADCVV
T
T
DVG
QH
QM
W
AA
QH
-
IAHTR
P
E
NF
I
T
S
S
--------
GL
G
T
MG
F
GLP
A
A
V
GA
QV
A
R
P
NDT
VVC
IS
GDG
SFM
M
NVQ
E
LG
T
VK
R
KQ
LP
L
K
IV
LL
D
N
QR
LG
M
V
R
-
QWQQ
L
FFQERYSETTLTDN
-----------
PD
F
LM
LA
S
A
F
G
IP
G
QH
I
TRKD
Q
VEA
AL
NTMLNS
---
DG
P
YL
L
HV
S
ID
EL
--------
E
NVW
P
L
V
PP
GA
S
N
S
EM
fig|344610.7.peg.2427
Escherichia coli 53638 (7-543/548)
V
V
HA
L
RAQ
GV
NT
V
F
G
YP
G
GA
I
MP
V
Y
D
A
L
YDG
-
G
-
V
E
H
L
LC
RHEQ
G
A
AMA
A
I
G
Y
A
RAT
GK
T
GV
--
C
IAT
SGPG
A
TN
L
ITGLA
D
A
LL
D
SI
P
VV
A
I
T
G
QVSAPF
IG
--
T
D
A
FQE
V
D
VL
--------
GLSLACT
K
HSF
LV
QSL
E
E
LP
RI
M
AE
A
FDV
A
S
S
-
GRPG
P
V
L
VD
I
P
K
D
I
QLASGDLE
---
PWFTTVENEV---
-
-TFPHA-E
V
EQ
A
RQM
L
AK
A
QK
P
M
L
YV
G
G
G
VGM
A
Q
A
VPA
L
R
E
FLATTKM
P
ATCT
L
K
GLG
AV
E
AD
Y
P
YYL
GM
L
GM
H
G
TKAANFA
V
Q
EC
D
L
L
IA
VG
A
RF
DD
R
VTGKLNT
F
A
P
-
H
A
SV
IH
M
DIDP
A
E
M
NKLRQAH
VA
L
Q
GD
----
L
NA
LL
PA
L
Q-----Q
PL
N
-
I
ND
W
Q
Q
HCAQL
R
DEHAWRYD--HPG
D
----------------------------
A
-
IYAPLLLKQ
L
SD
----
RKPADCVV
T
T
DVG
QH
QM
W
AA
QH
-
IAHTR
P
E
NF
I
T
S
S
--------
GL
G
T
MG
F
GLP
A
A
V
GA
QV
A
R
P
NDT
VVC
IS
GDG
SFM
M
NVQ
E
LG
T
VK
R
KQ
LP
L
K
IV
LL
D
N
QR
LG
M
V
R
-
QWQQ
L
FFQERYSETTLTDN
-----------
PD
F
LM
LA
S
A
F
G
IP
G
QH
I
TRKD
Q
VEA
AL
NTMLNS
---
DG
P
YL
L
HV
S
ID
EL
--------
E
NVW
P
L
V
PP
GA
S
N
S
EM
fig|481805.3.peg.4560
Escherichia coli ATCC 8739 (7-543/548)
V
V
HA
L
RAQ
GV
NT
V
F
G
YP
G
GA
I
MP
V
Y
D
A
L
YDG
-
G
-
V
E
H
L
LC
RHEQ
G
A
AMA
A
I
G
Y
A
RAT
GK
T
GV
--
C
IAT
SGPG
A
TN
L
ITGLA
D
A
LL
D
SI
P
VV
A
I
T
G
QVSAPF
IG
--
T
D
A
FQE
V
D
VL
--------
GLSLACT
K
HSF
LV
QSL
E
E
LP
RI
M
AE
A
FDV
A
S
S
-
GRPG
P
V
L
VD
I
P
K
D
I
QLASGDLE
---
PWFTTVENEV---
-
-TFPHA-E
V
EQ
A
RQM
L
AK
A
QK
P
M
L
YV
G
G
G
VGM
A
Q
A
VPA
L
R
E
FLATTKM
P
ATCT
L
K
GLG
AV
E
AD
Y
P
YYL
GM
L
GM
H
G
TKAANFA
V
Q
EC
D
L
L
IA
VG
A
RF
DD
R
VTGKLNT
F
A
P
-
H
A
SV
IH
M
DIDP
A
E
M
NKLRQAH
VA
L
Q
GD
----
L
NA
LL
PA
L
Q-----Q
PL
N
-
I
ND
W
Q
Q
HCAQL
R
DEHAWRYD--HPG
D
----------------------------
A
-
IYAPLLLKQ
L
SD
----
RKPADCVV
T
T
DVG
QH
QM
W
AA
QH
-
IAHTR
P
E
NF
I
T
S
S
--------
GL
G
T
MG
F
GLP
A
A
V
GA
QV
A
R
P
NDT
VVC
IS
GDG
SFM
M
NVQ
E
LG
T
VK
R
KQ
LP
L
K
IV
LL
D
N
QR
LG
M
V
R
-
QWQQ
L
FFQERYSETTLTDN
-----------
PD
F
LM
LA
S
A
F
G
IP
G
QH
I
TRKD
Q
VEA
AL
NTMLNS
---
DG
P
YL
L
HV
S
ID
EL
--------
E
NVW
P
L
V
PP
GA
S
N
S
EM
fig|481805.6.peg.4539
Escherichia coli ATCC 8739 (7-543/548)
V
V
HA
L
RAQ
GV
NT
V
F
G
YP
G
GA
I
MP
V
Y
D
A
L
YDG
-
G
-
V
E
H
L
LC
RHEQ
G
A
AMA
A
I
G
Y
A
RAT
GK
T
GV
--
C
IAT
SGPG
A
TN
L
ITGLA
D
A
LL
D
SI
P
VV
A
I
T
G
QVSAPF
IG
--
T
D
A
FQE
V
D
VL
--------
GLSLACT
K
HSF
LV
QSL
E
E
LP
RI
M
AE
A
FDV
A
S
S
-
GRPG
P
V
L
VD
I
P
K
D
I
QLASGDLE
---
PWFTTVENEV---
-
-TFPHA-E
V
EQ
A
RQM
L
AK
A
QK
P
M
L
YV
G
G
G
VGM
A
Q
A
VPA
L
R
E
FLATTKM
P
ATCT
L
K
GLG
AV
E
AD
Y
P
YYL
GM
L
GM
H
G
TKAANFA
V
Q
EC
D
L
L
IA
VG
A
RF
DD
R
VTGKLNT
F
A
P
-
H
A
SV
IH
M
DIDP
A
E
M
NKLRQAH
VA
L
Q
GD
----
L
NA
LL
PA
L
Q-----Q
PL
N
-
I
ND
W
Q
Q
HCAQL
R
DEHAWRYD--HPG
D
----------------------------
A
-
IYAPLLLKQ
L
SD
----
RKPADCVV
T
T
DVG
QH
QM
W
AA
QH
-
IAHTR
P
E
NF
I
T
S
S
--------
GL
G
T
MG
F
GLP
A
A
V
GA
QV
A
R
P
NDT
VVC
IS
GDG
SFM
M
NVQ
E
LG
T
VK
R
KQ
LP
L
K
IV
LL
D
N
QR
LG
M
V
R
-
QWQQ
L
FFQERYSETTLTDN
-----------
PD
F
LM
LA
S
A
F
G
IP
G
QH
I
TRKD
Q
VEA
AL
NTMLNS
---
DG
P
YL
L
HV
S
ID
EL
--------
E
NVW
P
L
V
PP
GA
S
N
S
EM
fig|331112.3.peg.3730
Escherichia coli HS (7-543/548)
V
V
HA
L
RAQ
GV
NT
V
F
G
YP
G
GA
I
MP
V
Y
D
A
L
YDG
-
G
-
V
E
H
L
LC
RHEQ
G
A
AMA
A
I
G
Y
A
RAT
GK
T
GV
--
C
IAT
SGPG
A
TN
L
ITGLA
D
A
LL
D
SI
P
VV
A
I
T
G
QVSAPF
IG
--
T
D
A
FQE
V
D
VL
--------
GLSLACT
K
HSF
LV
QSL
E
E
LP
RI
M
AE
A
FDV
A
S
S
-
GRPG
P
V
L
VD
I
P
K
D
I
QLASGDLE
---
PWFTTVENEV---
-
-TFPHA-E
V
EQ
A
RQM
L
AK
A
QK
P
M
L
YV
G
G
G
VGM
A
Q
A
VPA
L
R
E
FLATTKM
P
ATCT
L
K
GLG
AV
E
AD
Y
P
YYL
GM
L
GM
H
G
TKAANFA
V
Q
EC
D
L
L
IA
VG
A
RF
DD
R
VTGKLNT
F
A
P
-
H
A
SV
IH
M
DIDP
A
E
M
NKLRQAH
VA
L
Q
GD
----
L
NA
LL
PA
L
Q-----Q
PL
N
-
I
ND
W
Q
Q
HCAQL
R
DEHAWRYD--HPG
D
----------------------------
A
-
IYAPLLLKQ
L
SD
----
RKPADCVV
T
T
DVG
QH
QM
W
AA
QH
-
IAHTR
P
E
NF
I
T
S
S
--------
GL
G
T
MG
F
GLP
A
A
V
GA
QV
A
R
P
NDT
VVC
IS
GDG
SFM
M
NVQ
E
LG
T
VK
R
KQ
LP
L
K
IV
LL
D
N
QR
LG
M
V
R
-
QWQQ
L
FFQERYSETTLTDN
-----------
PD
F
LM
LA
S
A
F
G
IP
G
QH
I
TRKD
Q
VEA
AL
NTMLNS
---
DG
P
YL
L
HV
S
ID
EL
--------
E
NVW
P
L
V
PP
GA
S
N
S
EM
fig|331112.6.peg.3887
Escherichia coli HS (7-543/548)
V
V
HA
L
RAQ
GV
NT
V
F
G
YP
G
GA
I
MP
V
Y
D
A
L
YDG
-
G
-
V
E
H
L
LC
RHEQ
G
A
AMA
A
I
G
Y
A
RAT
GK
T
GV
--
C
IAT
SGPG
A
TN
L
ITGLA
D
A
LL
D
SI
P
VV
A
I
T
G
QVSAPF
IG
--
T
D
A
FQE
V
D
VL
--------
GLSLACT
K
HSF
LV
QSL
E
E
LP
RI
M
AE
A
FDV
A
S
S
-
GRPG
P
V
L
VD
I
P
K
D
I
QLASGDLE
---
PWFTTVENEV---
-
-TFPHA-E
V
EQ
A
RQM
L
AK
A
QK
P
M
L
YV
G
G
G
VGM
A
Q
A
VPA
L
R
E
FLATTKM
P
ATCT
L
K
GLG
AV
E
AD
Y
P
YYL
GM
L
GM
H
G
TKAANFA
V
Q
EC
D
L
L
IA
VG
A
RF
DD
R
VTGKLNT
F
A
P
-
H
A
SV
IH
M
DIDP
A
E
M
NKLRQAH
VA
L
Q
GD
----
L
NA
LL
PA
L
Q-----Q
PL
N
-
I
ND
W
Q
Q
HCAQL
R
DEHAWRYD--HPG
D
----------------------------
A
-
IYAPLLLKQ
L
SD
----
RKPADCVV
T
T
DVG
QH
QM
W
AA
QH
-
IAHTR
P
E
NF
I
T
S
S
--------
GL
G
T
MG
F
GLP
A
A
V
GA
QV
A
R
P
NDT
VVC
IS
GDG
SFM
M
NVQ
E
LG
T
VK
R
KQ
LP
L
K
IV
LL
D
N
QR
LG
M
V
R
-
QWQQ
L
FFQERYSETTLTDN
-----------
PD
F
LM
LA
S
A
F
G
IP
G
QH
I
TRKD
Q
VEA
AL
NTMLNS
---
DG
P
YL
L
HV
S
ID
EL
--------
E
NVW
P
L
V
PP
GA
S
N
S
EM
fig|749537.3.peg.4880
Escherichia coli MS 115-1 (7-543/548)
V
V
HA
L
RAQ
GV
NT
V
F
G
YP
G
GA
I
MP
V
Y
D
A
L
YDG
-
G
-
V
E
H
L
LC
RHEQ
G
A
AMA
A
I
G
Y
A
RAT
GK
T
GV
--
C
IAT
SGPG
A
TN
L
ITGLA
D
A
LL
D
SI
P
VV
A
I
T
G
QVSAPF
IG
--
T
D
A
FQE
V
D
VL
--------
GLSLACT
K
HSF
LV
QSL
E
E
LP
RI
M
AA
A
FEV
A
S
S
-
GRPG
P
V
L
VD
I
P
K
D
I
QLASGDLE
---
PWFTTVENEV---
-
-TFPHA-E
V
EQ
A
RQM
L
AK
A
QK
P
M
L
YV
G
G
G
VGM
A
Q
A
VPA
L
R
E
FLATTKM
P
ATCT
L
K
GLG
AV
E
AD
Y
P
YYL
GM
L
GM
H
G
TKAANFA
V
Q
EC
D
L
L
IA
VG
A
RF
DD
R
VTGKLNT
F
A
P
-
H
A
SV
IH
M
DIDP
A
E
M
NKLRQAH
VA
L
Q
GD
----
L
NA
LL
PA
L
Q-----Q
PL
N
-
I
ND
W
Q
Q
HCAQL
R
DEHAWRYD--HPG
D
----------------------------
A
-
IYAPLLLKQ
L
SD
----
RKPADCVV
T
T
DVG
QH
QM
W
AA
QH
-
IAHTR
P
E
NF
I
T
S
S
--------
GL
G
T
MG
F
GLP
A
A
V
GA
QV
A
R
P
NDT
VVC
IS
GDG
SFM
M
NVQ
E
LG
T
VK
R
KQ
LP
L
K
IV
LL
D
N
QR
LG
M
V
R
-
QWQQ
L
FFQERYSETTLTDN
-----------
PD
F
LM
LA
S
A
F
G
IP
G
QH
I
TRKD
Q
VEA
AL
DTMLNS
---
DG
P
YL
L
HV
S
ID
EL
--------
E
NVW
P
L
V
PP
GA
S
N
S
EM
fig|550672.3.peg.3841
Escherichia coli B088 (7-543/548)
V
V
HA
L
RAQ
GV
NT
V
F
G
YP
G
GA
I
MP
V
Y
D
A
L
YDG
-
G
-
V
E
H
L
LC
RHEQ
G
A
AMA
A
I
G
Y
A
RAT
GK
T
GV
--
C
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SGPG
A
TN
L
ITGLA
D
A
LL
D
SI
P
VV
A
I
T
G
QVSAPF
IG
--
T
D
A
FQE
V
D
VL
--------
GLSLACT
K
HSF
LV
QSL
E
E
LP
RI
M
AE
A
FDV
A
S
S
-
GRPG
P
V
L
VD
I
P
K
D
I
QLASGDLE
---
PWFTTVENEV---
-
-TFPHA-E
V
EQ
A
RQM
L
AK
A
QK
P
M
L
YV
G
G
G
VGM
A
Q
A
VPA
L
R
E
FLATTKM
P
ATCT
L
K
GLG
AV
E
AD
Y
P
YYL
GM
L
GM
H
G
TKAANFA
V
Q
EC
D
L
L
IA
VG
A
RF
DD
R
VTGKLNT
F
A
P
-
H
A
SV
IH
M
DIDP
A
E
M
NKLRQAH
VA
L
Q
GD
----
L
NA
LL
PA
L
Q-----Q
PL
N
-
I
ND
W
Q
Q
HCAQL
R
DEHSWRYD--HPG
D
----------------------------
A
-
IYAPLLLKQ
L
SD
----
RKPADCVV
T
T
DVG
QH
QM
W
AA
QH
-
IAHTR
P
E
NF
I
T
S
S
--------
GL
G
T
MG
F
GLP
A
A
V
GA
QV
A
R
P
NDT
VVC
IS
GDG
SFM
M
NVQ
E
LG
T
VK
R
KQ
LP
L
K
IV
LL
D
N
QR
LG
M
V
R
-
QWQQ
L
FFQERYSETTLTDN
-----------
PD
F
LM
LA
S
A
F
G
IP
G
QH
I
TRKD
Q
VEA
AL
DTMLNS
---
DG
P
YL
L
HV
S
ID
EL
--------
E
NVW
P
L
V
PP
GA
S
N
S
EM
fig|585034.4.peg.3858
Escherichia coli IAI1 (7-543/548)
V
V
HA
L
RAQ
GV
NT
V
F
G
YP
G
GA
I
MP
V
Y
D
A
L
YDG
-
G
-
V
E
H
L
LC
RHEQ
G
A
AMA
A
I
G
Y
A
RAT
GK
T
GV
--
C
IAT
SGPG
A
TN
L
ITGLA
D
A
LL
D
SI
P
VV
A
I
T
G
QVSAPF
IG
--
T
D
A
FQE
V
D
VL
--------
GLSLACT
K
HSF
LV
QSL
E
E
LP
RI
M
AE
A
FDV
A
S
S
-
GRPG
P
V
L
VD
I
P
K
D
I
QLASGDLE
---
PWFTTVENEV---
-
-TFPHA-E
V
EQ
A
RQM
L
AK
A
QK
P
M
L
YV
G
G
G
VGM
A
Q
A
VPA
L
R
E
FLATTKM
P
ATCT
L
K
GLG
AV
E
AD
Y
P
YYL
GM
L
GM
H
G
TKAANFA
V
Q
EC
D
L
L
IA
VG
A
RF
DD
R
VTGKLNT
F
A
P
-
H
A
SV
IH
M
DIDP
A
E
M
NKLRQAH
VA
L
Q
GD
----
L
NA
LL
PA
L
Q-----Q
PL
N
-
I
ND
W
Q
Q
HCAQL
R
DEHSWRYD--HPG
D
----------------------------
A
-
IYAPLLLKQ
L
SD
----
RKPADCVV
T
T
DVG
QH
QM
W
AA
QH
-
IAHTR
P
E
NF
I
T
S
S
--------
GL
G
T
MG
F
GLP
A
A
V
GA
QV
A
R
P
NDT
VVC
IS
GDG
SFM
M
NVQ
E
LG
T
VK
R
KQ
LP
L
K
IV
LL
D
N
QR
LG
M
V
R
-
QWQQ
L
FFQERYSETTLTDN
-----------
PD
F
LM
LA
S
A
F
G
IP
G
QH
I
TRKD
Q
VEA
AL
DTMLNS
---
DG
P
YL
L
HV
S
ID
EL
--------
E
NVW
P
L
V
PP
GA
S
N
S
EM
fig|585034.5.peg.3855
Escherichia coli IAI1 (7-543/548)
V
V
HA
L
RAQ
GV
NT
V
F
G
YP
G
GA
I
MP
V
Y
D
A
L
YDG
-
G
-
V
E
H
L
LC
RHEQ
G
A
AMA
A
I
G
Y
A
RAT
GK
T
GV
--
C
IAT
SGPG
A
TN
L
ITGLA
D
A
LL
D
SI
P
VV
A
I
T
G
QVSAPF
IG
--
T
D
A
FQE
V
D
VL
--------
GLSLACT
K
HSF
LV
QSL
E
E
LP
RI
M
AE
A
FDV
A
S
S
-
GRPG
P
V
L
VD
I
P
K
D
I
QLASGDLE
---
PWFTTVENEV---
-
-TFPHA-E
V
EQ
A
RQM
L
AK
A
QK
P
M
L
YV
G
G
G
VGM
A
Q
A
VPA
L
R
E
FLATTKM
P
ATCT
L
K
GLG
AV
E
AD
Y
P
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GM
L
GM
H
G
TKAANFA
V
Q
EC
D
L
L
IA
VG
A
RF
DD
R
VTGKLNT
F
A
P
-
H
A
SV
IH
M
DIDP
A
E
M
NKLRQAH
VA
L
Q
GD
----
L
NA
LL
PA
L
Q-----Q
PL
N
-
I
ND
W
Q
Q
HCAQL
R
DEHSWRYD--HPG
D
----------------------------
A
-
IYAPLLLKQ
L
SD
----
RKPADCVV
T
T
DVG
QH
QM
W
AA
QH
-
IAHTR
P
E
NF
I
T
S
S
--------
GL
G
T
MG
F
GLP
A
A
V
GA
QV
A
R
P
NDT
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IS
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M
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E
LG
T
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R
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LP
L
K
IV
LL
D
N
QR
LG
M
V
R
-
QWQQ
L
FFQERYSETTLTDN
-----------
PD
F
LM
LA
S
A
F
G
IP
G
QH
I
TRKD
Q
VEA
AL
DTMLNS
---
DG
P
YL
L
HV
S
ID
EL
--------
E
NVW
P
L
V
PP
GA
S
N
S
EM
fig|656393.3.peg.4937
Escherichia coli H299 (7-543/548)
V
V
HA
L
RAQ
GV
NT
V
F
G
YP
G
GA
I
MP
V
Y
D
A
L
YDG
-
G
-
M
E
H
L
LC
RHEQ
G
A
AMA
A
I
G
Y
A
RAT
GK
T
GV
--
C
IAT
SGPG
A
TN
L
ITGLA
D
A
LL
D
SI
P
VV
A
I
T
G
QVSAPF
IG
--
T
D
A
FQE
V
D
IL
--------
GLSLACT
K
HSF
LV
QSL
E
E
LP
RI
M
AE
A
FDV
A
S
S
-
GRPG
P
V
L
VD
I
P
K
D
I
QLASGDLE
---
PWFTTVENEV---
-
-TFPHA-E
V
EQ
A
RQM
L
AK
A
QK
P
M
L
YV
G
G
G
VGM
A
Q
A
VSA
L
R
E
FLATTKM
P
ATCT
L
K
GLG
AV
E
AD
Y
P
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GM
L
GM
H
G
TKAANFA
V
Q
EC
D
L
L
IA
VG
A
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A
P
-
H
A
SV
IH
M
DIDP
A
E
M
NKLRQAH
VA
L
Q
D
D
----
L
NA
LL
PA
L
Q-----Q
PL
N
-
I
DD
W
Q
Q
HCAQL
R
DEHAWRYD--HPG
D
----------------------------
A
-
IYAPLLLKQ
L
SD
----
RKSADCIV
T
T
DVG
QH
QM
W
AA
QH
-
IVHTR
P
E
NF
I
T
S
S
--------
GL
G
T
MG
F
GLP
A
A
V
GA
QV
A
R
P
NDT
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IS
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M
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E
LG
T
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R
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LP
L
K
IV
LL
D
N
QR
LG
M
V
R
-
QWQQ
L
FFQERYSETTLTDN
-----------
PD
F
LM
LA
S
A
F
G
IP
G
QH
I
THKD
Q
VEA
AL
DTMLNS
---
DG
P
YL
L
HV
S
ID
EF
--------
E
NVW
P
L
V
PP
GA
S
N
S
EM
fig|83333.1.peg.3698
Escherichia coli K12 (7-543/548)
V
V
HA
L
RAQ
GV
NT
V
F
G
YP
G
GA
I
MP
V
Y
D
A
L
YDG
-
G
-
V
E
H
L
LC
RHEQ
G
A
AMA
A
I
G
Y
A
RAT
GK
T
GV
--
C
IAT
SGPG
A
TN
L
ITGLA
D
A
LL
D
SI
P
VV
A
I
T
G
QVSAPF
IG
--
T
D
A
FQE
V
D
VL
--------
GLSLACT
K
HSF
LV
QSL
E
E
LP
RI
M
AE
A
FDV
A
C
S
-
GRPG
P
V
L
VD
I
P
K
D
I
QLASGDLE
---
PWFTTVENEV---
-
-TFPHA-E
V
EQ
A
RQM
L
AK
A
QK
P
M
L
YV
G
G
G
VGM
A
Q
A
VPA
L
R
E
FLAATKM
P
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L
K
GLG
AV
E
AD
Y
P
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GM
L
GM
H
G
TKAANFA
V
Q
EC
D
L
L
IA
VG
A
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A
P
-
H
A
SV
IH
M
DIDP
A
E
M
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L
Q
GD
----
L
NA
LL
PA
L
Q-----Q
PL
N
-
Q
ND
W
Q
Q
HCAQL
R
DEHSWRYD--HPG
D
----------------------------
A
-
IYAPLLLKQ
L
SD
----
RKPADCVV
T
T
DVG
QH
QM
W
AA
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-
IAHTR
P
E
NF
I
T
S
S
--------
GL
G
T
MG
F
GLP
A
A
V
GA
QV
A
R
P
NDT
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IS
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M
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E
LG
T
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R
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LP
L
K
IV
LL
D
N
QR
LG
M
V
R
-
QWQQ
L
FFQERYSETTLTDN
-----------
PD
F
LM
LA
S
A
F
G
IH
G
QH
I
TRKD
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AL
DTMLNS
---
DG
P
YL
L
HV
S
ID
EL
--------
E
NVW
P
L
V
PP
GA
S
N
S
EM
fig|544404.4.peg.4892
Escherichia coli O157:H7 str. TW14359 (1-537/542)
M
V
HA
L
RAQ
GV
NT
V
F
G
YP
G
GA
I
MP
V
Y
D
A
L
YDG
-
G
-
V
E
H
L
LC
RHEQ
G
A
AMA
A
I
G
Y
A
RAT
GK
T
GV
--
C
IAT
SGPG
A
TN
L
ITGLA
D
A
LL
D
SI
P
VV
A
I
T
G
QVSAPF
IG
--
T
D
A
FQE
V
D
VL
--------
GLSLACT
K
HSF
LV
QSL
E
E
LP
RI
M
AE
A
FDV
A
S
S
-
GRPG
P
V
L
VD
I
P
K
D
I
QLASGDLE
---
PWFTTVENEV---
-
-TFPHA-E
V
EQ
A
RQM
L
AK
A
QK
P
M
L
YV
G
G
G
VGM
A
Q
A
VPA
L
R
E
FLATTKM
P
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L
K
GLG
AV
E
AD
Y
P
YYL
GM
L
GM
H
G
TKAANFA
V
Q
EC
D
L
L
IA
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A
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DD
R
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F
A
P
-
H
A
SV
IH
M
DIDP
A
E
M
NKLRQAH
VA
L
Q
GD
----
L
NA
LL
PA
L
Q-----Q
PL
N
-
I
ND
W
Q
Q
YCAQL
R
DEHAWRYD--HPG
D
----------------------------
A
-
IYAPLLLKQ
L
SD
----
RKPADCVV
T
T
DVG
QH
QM
W
AA
QH
-
IAHTR
P
E
NF
I
T
S
S
--------
GL
G
T
MG
F
GLP
A
A
V
GA
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A
R
P
NDT
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IS
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SFM
M
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E
LG
T
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R
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LP
L
K
IV
LL
D
N
QR
LG
M
V
R
-
QWQQ
L
FFQERYSETTLTDN
-----------
PD
F
LK
LA
S
A
F
G
IP
G
QH
I
TRKD
Q
VEA
AL
DTMLNS
---
DG
P
YL
L
HV
S
ID
EL
--------
E
NVW
P
L
V
PP
GA
S
N
S
EM
fig|340186.3.peg.4258
Escherichia coli E110019 (7-543/548)
V
V
HA
L
RAQ
GV
NT
V
F
G
YP
G
GA
I
MP
V
Y
D
A
L
YDG
-
G
-
V
E
H
L
LC
RHEQ
G
A
AMA
A
I
G
Y
A
RAT
GK
T
GV
--
C
IAT
SGPG
A
TN
L
ITGLA
D
A
LL
D
SI
P
VV
A
I
T
G
QVSAPF
IG
--
T
D
A
FQE
V
D
VL
--------
GLSLACT
K
HSF
LV
QSL
E
E
LP
RI
M
AA
A
FDV
A
S
S
-
GRPG
P
V
L
VD
I
P
K
D
I
QLASGDLE
---
PWFTTVENEV---
-
-TFPHA-E
V
EQ
A
RQM
L
AK
A
QK
P
M
L
YV
G
G
G
VGM
A
Q
A
VPA
L
R
E
FLATTKM
P
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L
K
GLG
AV
E
AD
Y
P
YYL
GM
L
GM
H
G
TKAANFA
V
Q
EC
D
L
L
IA
VG
A
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DD
R
VTGKLNT
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A
P
-
H
A
SV
IH
M
DIDP
A
E
M
NKLRQAH
VA
L
Q
GD
----
L
NA
LL
PA
L
Q-----Q
PL
N
-
I
ND
W
Q
Q
HCAQL
R
DEHSWRYD--HPG
D
----------------------------
A
-
IYAPLLLKQ
L
SD
----
RKPADCVV
T
T
DVG
QH
QM
W
AA
QH
-
IAHTR
P
E
NF
I
T
S
S
--------
GL
G
T
MG
F
GLP
A
A
V
GA
QV
A
R
P
NDT
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IS
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SFM
M
NVQ
E
LG
T
VK
R
KQ
LP
L
K
IV
LL
D
N
QR
LG
M
V
R
-
QWQQ
L
FFQERYSETTLTDN
-----------
PD
F
LM
LA
S
A
F
G
IP
G
QH
I
TRKD
Q
VEA
AL
DTMLNS
---
DG
P
YL
L
HV
S
ID
EL
--------
E
NVW
P
L
V
PP
GA
S
N
S
EM
fig|340186.5.peg.4478
Escherichia coli E110019 (7-543/548)
V
V
HA
L
RAQ
GV
NT
V
F
G
YP
G
GA
I
MP
V
Y
D
A
L
YDG
-
G
-
V
E
H
L
LC
RHEQ
G
A
AMA
A
I
G
Y
A
RAT
GK
T
GV
--
C
IAT
SGPG
A
TN
L
ITGLA
D
A
LL
D
SI
P
VV
A
I
T
G
QVSAPF
IG
--
T
D
A
FQE
V
D
VL
--------
GLSLACT
K
HSF
LV
QSL
E
E
LP
RI
M
AA
A
FDV
A
S
S
-
GRPG
P
V
L
VD
I
P
K
D
I
QLASGDLE
---
PWFTTVENEV---
-
-TFPHA-E
V
EQ
A
RQM
L
AK
A
QK
P
M
L
YV
G
G
G
VGM
A
Q
A
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L
R
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FLATTKM
P
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L
K
GLG
AV
E
AD
Y
P
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GM
L
GM
H
G
TKAANFA
V
Q
EC
D
L
L
IA
VG
A
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A
P
-
H
A
SV
IH
M
DIDP
A
E
M
NKLRQAH
VA
L
Q
GD
----
L
NA
LL
PA
L
Q-----Q
PL
N
-
I
ND
W
Q
Q
HCAQL
R
DEHSWRYD--HPG
D
----------------------------
A
-
IYAPLLLKQ
L
SD
----
RKPADCVV
T
T
DVG
QH
QM
W
AA
QH
-
IAHTR
P
E
NF
I
T
S
S
--------
GL
G
T
MG
F
GLP
A
A
V
GA
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A
R
P
NDT
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IS
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M
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L
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D
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QWQQ
L
FFQERYSETTLTDN
-----------
PD
F
LM
LA
S
A
F
G
IP
G
QH
I
TRKD
Q
VEA
AL
DTMLNS
---
DG
P
YL
L
HV
S
ID
EL
--------
E
NVW
P
L
V
PP
GA
S
N
S
EM
fig|656444.3.peg.5104
Escherichia coli TA280 (7-543/548)
V
V
HA
L
RAQ
GV
NT
V
F
G
YP
G
GA
I
MP
V
Y
D
A
L
YDG
-
G
-
V
E
H
L
LC
RHEQ
G
A
AMA
A
I
G
Y
A
RAT
GK
T
GV
--
C
IAT
SGPG
A
TN
L
ITGLA
D
A
LL
D
SI
P
VV
A
I
T
G
QVSAPF
IG
--
T
D
A
FQE
V
D
VL
--------
GLSLACT
K
HSF
LV
QSL
E
E
LP
RI
M
AE
A
FNV
A
S
S
-
GRPG
P
V
L
VD
I
P
K
D
I
QLASGDLE
---
PWFTTVENEV---
-
-NFPHA-E
V
EQ
A
RQM
L
AK
A
QK
P
M
L
YV
G
G
G
VGM
A
Q
A
VPA
L
R
E
FLAATKM
P
VTCT
L
K
GLG
AV
E
AD
Y
P
YYL
GM
L
GM
H
G
TKAANFA
V
Q
EC
D
L
L
IA
VG
A
RF
DD
R
VTGKLNT
F
A
P
-
H
A
SV
IH
M
DIDP
A
E
M
NKLRQVH
VA
L
Q
GD
----
L
NA
LL
PA
L
Q-----Q
PL
N
-
I
ND
W
Q
Q
YCAQL
R
DEHAWRYD--HPG
D
----------------------------
A
-
IYAPLLLKQ
L
SD
----
RKPADCVV
T
T
DVG
QH
QM
W
AA
QH
-
IAHTR
P
E
NF
I
T
S
S
--------
GL
G
T
MG
F
GLP
A
A
V
GA
QV
A
R
P
NDT
VVC
IS
GDG
SFM
M
NVQ
E
LG
T
VK
R
KQ
LP
L
K
IV
LL
D
N
QR
LG
M
V
R
-
QWQQ
L
FFQERYSETTLTDN
-----------
PD
F
LM
LA
S
A
F
G
IP
G
QH
I
TRKD
Q
VEA
AL
DTMLNS
---
DG
P
YL
L
HV
S
ID
EL
--------
E
NVW
P
L
V
PP
GA
S
N
S
EM
fig|585057.4.peg.3124
Escherichia coli IAI39 (7-543/548)
V
V
HA
L
RAQ
GV
NT
V
F
G
YP
G
GA
I
MP
V
Y
D
A
L
YDG
-
G
-
M
E
H
L
LC
RHEQ
G
A
AMA
A
I
G
Y
A
RAT
GK
T
GV
--
C
IAT
SGPG
A
TN
L
ITGLA
D
A
LL
D
SI
P
VV
A
I
T
G
QVSAPF
IG
--
T
D
A
FQE
V
D
IL
--------
GLSLACT
K
HSF
LV
QSL
E
E
LP
RI
M
AE
A
FDV
A
S
S
-
GRPG
P
V
L
VD
I
P
K
D
I
QLASGDLE
---
PWFTTVENEV---
-
-TFPHA-E
V
EQ
A
RQM
L
AK
A
QK
P
M
L
YV
G
G
G
VGM
A
Q
A
VSA
L
R
E
FLAATKM
P
ATCT
L
K
GLG
AV
E
AD
Y
P
YYL
GM
L
GM
H
G
TKAANFA
V
Q
EC
D
L
L
IA
VG
A
RF
DD
R
VTGKLNT
F
A
P
-
L
A
SV
IH
M
DIDP
A
E
M
NKLRQAH
VA
L
Q
GD
----
L
NA
LL
PA
L
Q-----Q
PL
N
-
I
ND
W
Q
Q
YCAQL
R
DEHTWRYD--HPG
D
----------------------------
A
-
IYAPLLLKK
L
SD
----
RKPADCVV
T
T
DVG
QH
QM
W
AA
QH
-
IAHTR
P
E
NF
I
T
S
S
--------
GL
G
T
MG
F
GLP
A
A
V
GA
QV
A
R
P
NDT
VVC
IS
GDG
SFM
M
NVQ
E
LG
T
VK
R
KQ
LP
L
K
IV
LL
D
N
QR
LG
M
V
R
-
QWQQ
L
FFQERYSETTLTDN
-----------
PD
F
LM
LA
S
A
F
G
IP
G
QH
I
TRKD
Q
VEA
AL
DTMLNS
---
DG
P
YL
L
HV
S
ID
EL
--------
E
NVW
P
L
V
PP
GA
S
N
S
EM
fig|585057.6.peg.3130
Escherichia coli IAI39 (7-543/548)
V
V
HA
L
RAQ
GV
NT
V
F
G
YP
G
GA
I
MP
V
Y
D
A
L
YDG
-
G
-
M
E
H
L
LC
RHEQ
G
A
AMA
A
I
G
Y
A
RAT
GK
T
GV
--
C
IAT
SGPG
A
TN
L
ITGLA
D
A
LL
D
SI
P
VV
A
I
T
G
QVSAPF
IG
--
T
D
A
FQE
V
D
IL
--------
GLSLACT
K
HSF
LV
QSL
E
E
LP
RI
M
AE
A
FDV
A
S
S
-
GRPG
P
V
L
VD
I
P
K
D
I
QLASGDLE
---
PWFTTVENEV---
-
-TFPHA-E
V
EQ
A
RQM
L
AK
A
QK
P
M
L
YV
G
G
G
VGM
A
Q
A
VSA
L
R
E
FLAATKM
P
ATCT
L
K
GLG
AV
E
AD
Y
P
YYL
GM
L
GM
H
G
TKAANFA
V
Q
EC
D
L
L
IA
VG
A
RF
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R
VTGKLNT
F
A
P
-
L
A
SV
IH
M
DIDP
A
E
M
NKLRQAH
VA
L
Q
GD
----
L
NA
LL
PA
L
Q-----Q
PL
N
-
I
ND
W
Q
Q
YCAQL
R
DEHTWRYD--HPG
D
----------------------------
A
-
IYAPLLLKK
L
SD
----
RKPADCVV
T
T
DVG
QH
QM
W
AA
QH
-
IAHTR
P
E
NF
I
T
S
S
--------
GL
G
T
MG
F
GLP
A
A
V
GA
QV
A
R
P
NDT
VVC
IS
GDG
SFM
M
NVQ
E
LG
T
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R
KQ
LP
L
K
IV
LL
D
N
QR
LG
M
V
R
-
QWQQ
L
FFQERYSETTLTDN
-----------
PD
F
LM
LA
S
A
F
G
IP
G
QH
I
TRKD
Q
VEA
AL
DTMLNS
---
DG
P
YL
L
HV
S
ID
EL
--------
E
NVW
P
L
V
PP
GA
S
N
S
EM
fig|585396.4.peg.4756
Escherichia coli O111:H- str. 11128 (7-543/548)
V
V
HA
L
RAQ
GV
NT
V
F
G
YP
G
GA
I
MP
V
Y
D
A
L
YDG
-
G
-
V
E
H
L
LC
RHEQ
G
A
AMA
A
I
G
Y
A
RAT
GK
T
GV
--
C
IAT
SGPG
A
TN
L
ITGLA
D
A
LL
D
SI
P
VV
A
I
T
G
QVSAPF
IG
--
T
D
A
FQE
V
D
VL
--------
GLSLACT
K
HSF
LV
QSL
E
E
LP
RI
M
AE
A
FDV
A
S
S
-
GRPG
P
V
L
VD
I
P
K
D
I
QLASGDLE
---
PWFTTVENEV---
-
-TFPHA-E
V
EQ
A
RQM
L
AK
A
QK
P
M
L
YV
G
G
G
VGM
A
Q
A
VPA
L
R
E
FLATTKM
P
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L
K
GLG
AV
E
AD
Y
P
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GM
L
GM
H
G
TKAANFA
V
Q
EC
D
L
L
IA
VG
A
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R
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F
A
P
-
H
A
SV
IH
M
DIDP
A
E
M
NKLRQAH
VA
L
Q
GD
----
L
NA
LL
PA
L
Q-----Q
PL
N
-
I
ND
W
Q
Q
YCAQL
R
DEHTWRYD--HPG
D
----------------------------
A
-
IYAPLLLKQ
L
SD
----
RKPADCVV
T
T
DVG
QH
QM
W
AA
QH
-
IAHTR
P
E
NF
I
T
S
S
--------
GL
G
T
MG
F
GLP
A
A
V
GA
QV
A
R
P
NDT
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IS
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SFM
M
NVQ
E
LG
T
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R
KQ
LP
L
K
IV
LL
D
N
QR
LG
M
V
R
-
QWQQ
L
FFQERYSETTLTDN
-----------
PD
F
LM
LA
S
A
F
G
IP
G
QH
I
TRKD
Q
VEA
AL
DTMLNS
---
DG
P
YL
L
HV
S
ID
EL
--------
E
NVW
P
L
V
PP
GA
S
N
S
EM
fig|573235.3.peg.4963
Escherichia coli O26:H11 str. 11368 (7-543/548)
V
V
HA
L
RAQ
GV
NT
V
F
G
YP
G
GA
I
MP
V
Y
D
A
L
YDG
-
G
-
V
E
H
L
LC
RHEQ
G
A
AMA
A
I
G
Y
A
RAT
GK
T
GV
--
C
IAT
SGPG
A
TN
L
ITGLA
D
A
LL
D
SI
P
VV
A
I
T
G
QVSAPF
IG
--
T
D
A
FQE
V
D
VL
--------
GLSLACT
K
HSF
LV
QSL
E
E
LP
RI
M
AE
A
FDV
A
S
S
-
GRPG
P
V
L
VD
I
P
K
D
I
QLASGDLE
---
PWFTTVENEV---
-
-TFPHA-E
V
EQ
A
RQM
L
AK
A
QK
P
M
L
YV
G
G
G
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A
Q
A
VPA
L
R
E
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P
ATCT
L
K
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AV
E
AD
Y
P
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GM
L
GM
H
G
TKAANFA
V
Q
EC
D
L
L
IA
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A
RF
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R
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A
P
-
H
A
SV
IH
M
DIDP
A
E
M
NKLRQAH
VA
L
Q
GD
----
L
NA
LL
PA
L
Q-----Q
PL
N
-
I
ND
W
Q
Q
YCAQL
R
DEHTWRYD--HPG
D
----------------------------
A
-
IYAPLLLKQ
L
SD
----
RKPADCVV
T
T
DVG
QH
QM
W
AA
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-
IAHTR
P
E
NF
I
T
S
S
--------
GL
G
T
MG
F
GLP
A
A
V
GA
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A
R
P
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IS
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SFM
M
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LG
T
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R
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LP
L
K
IV
LL
D
N
QR
LG
M
V
R
-
QWQQ
L
FFQERYSETTLTDN
-----------
PD
F
LM
LA
S
A
F
G
IP
G
QH
I
TRKD
Q
VEA
AL
DTMLNS
---
DG
P
YL
L
HV
S
ID
EL
--------
E
NVW
P
L
V
PP
GA
S
N
S
EM
fig|344601.3.peg.4114
Escherichia coli B171 (7-543/548)
V
V
HA
L
RAQ
GV
NT
V
F
G
YP
G
GA
I
MP
V
Y
D
A
L
YDG
-
G
-
V
E
H
L
LC
RHEQ
G
A
AMA
A
I
G
Y
A
RAT
GK
T
GV
--
C
IAT
SGPG
A
TN
L
ITGLA
D
A
LL
D
SI
P
VV
A
I
T
G
QVSAPF
IG
--
T
D
A
FQE
V
D
VL
--------
GLSLACT
K
HSF
LV
QSL
E
E
LP
RI
M
AE
A
FDV
A
S
S
-
GRPG
P
V
L
VD
I
P
K
D
I
QLASGDLE
---
PWFTTVENEV---
-
-TFPHA-E
V
EQ
A
RQM
L
AK
A
QK
P
M
L
YV
G
G
G
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A
Q
A
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L
R
E
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P
ATCT
L
K
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AV
E
AD
Y
P
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GM
L
GM
H
G
TKAANFA
V
Q
EC
D
L
L
IA
VG
A
RF
DD
R
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F
A
P
-
H
A
SV
IH
M
DIDP
T
E
M
NKLRQAH
VA
L
Q
GD
----
L
NA
LL
PA
L
Q-----Q
PL
N
-
I
ND
W
Q
L
HCAQL
R
DEHAWRYD--HPG
D
----------------------------
A
-
IYAPLLLKQ
L
SD
----
RKPADCVV
T
T
DVG
QH
QM
W
AA
QH
-
IAHTR
P
E
NF
I
T
S
S
--------
GL
G
T
MG
F
GLP
A
A
V
GA
QV
A
R
P
NDT
VVC
IS
GDG
SFM
M
NVQ
E
LG
T
VK
R
KQ
LP
L
K
IV
LL
D
N
QR
LG
M
V
R
-
QWQQ
L
FFQERYSETTLTDN
-----------
PD
F
LM
LA
S
A
F
G
IP
G
QH
I
TRKD
Q
VEA
AL
DTMLNS
---
DG
P
YL
L
HV
S
ID
EL
--------
E
NVW
P
L
V
PP
GA
S
N
S
EM
fig|344601.5.peg.4332
Escherichia coli B171 (7-543/548)
V
V
HA
L
RAQ
GV
NT
V
F
G
YP
G
GA
I
MP
V
Y
D
A
L
YDG
-
G
-
V
E
H
L
LC
RHEQ
G
A
AMA
A
I
G
Y
A
RAT
GK
T
GV
--
C
IAT
SGPG
A
TN
L
ITGLA
D
A
LL
D
SI
P
VV
A
I
T
G
QVSAPF
IG
--
T
D
A
FQE
V
D
VL
--------
GLSLACT
K
HSF
LV
QSL
E
E
LP
RI
M
AE
A
FDV
A
S
S
-
GRPG
P
V
L
VD
I
P
K
D
I
QLASGDLE
---
PWFTTVENEV---
-
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V
EQ
A
RQM
L
AK
A
QK
P
M
L
YV
G
G
G
VGM
A
Q
A
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L
R
E
FLATTKM
P
ATCT
L
K
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AV
E
AD
Y
P
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GM
L
GM
H
G
TKAANFA
V
Q
EC
D
L
L
IA
VG
A
RF
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R
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F
A
P
-
H
A
SV
IH
M
DIDP
T
E
M
NKLRQAH
VA
L
Q
GD
----
L
NA
LL
PA
L
Q-----Q
PL
N
-
I
ND
W
Q
L
HCAQL
R
DEHAWRYD--HPG
D
----------------------------
A
-
IYAPLLLKQ
L
SD
----
RKPADCVV
T
T
DVG
QH
QM
W
AA
QH
-
IAHTR
P
E
NF
I
T
S
S
--------
GL
G
T
MG
F
GLP
A
A
V
GA
QV
A
R
P
NDT
VVC
IS
GDG
SFM
M
NVQ
E
LG
T
VK
R
KQ
LP
L
K
IV
LL
D
N
QR
LG
M
V
R
-
QWQQ
L
FFQERYSETTLTDN
-----------
PD
F
LM
LA
S
A
F
G
IP
G
QH
I
TRKD
Q
VEA
AL
DTMLNS
---
DG
P
YL
L
HV
S
ID
EL
--------
E
NVW
P
L
V
PP
GA
S
N
S
EM
fig|216592.1.peg.1144
Escherichia coli 042 (7-543/548)
V
V
HA
L
RAQ
GV
NT
V
F
G
YP
G
GA
I
MP
V
Y
D
A
L
YDG
-
G
-
V
E
H
L
LC
RHEQ
G
A
AMA
A
I
G
Y
A
RAT
GK
T
GV
--
C
IAT
SGPG
A
TN
L
ITGLA
D
A
LL
D
SI
P
VV
A
I
T
G
QVSAPF
IG
--
T
D
A
FQE
V
D
VL
--------
GLSLACT
K
HSF
LV
QSL
E
E
LP
RI
M
AE
A
FDV
A
G
S
-
GRPG
P
V
L
VD
I
P
K
D
I
QLASGDLE
---
PWFTTVENEV---
-
-NFPHA-E
V
EQ
A
RQM
L
AK
A
QK
P
M
L
YV
G
G
G
VGM
A
Q
A
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L
R
E
FLAATKM
P
VTCT
L
K
GLG
AV
E
AD
Y
P
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GM
L
GM
H
G
TKAANFA
V
Q
EC
D
L
L
IA
VG
A
RF
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R
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F
A
P
-
L
A
SV
IH
M
DIDP
A
E
M
NKLRQAH
VA
L
Q
GD
----
L
NA
LL
PA
L
Q-----Q
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N
-
I
ND
W
Q
Q
YCAQL
R
DEHTWRYD--HPG
D
----------------------------
A
-
IYAPLLLKQ
L
SD
----
RKPADCVV
T
T
DVG
QH
QM
W
AA
QH
-
IAHTR
P
E
NF
I
T
S
S
--------
GL
G
T
MG
F
GLP
A
A
V
GA
QV
A
R
P
NDT
VVC
IS
GDG
SFM
M
NVQ
E
LG
T
VK
R
KQ
LP
L
K
IV
LL
D
N
QR
LG
M
V
R
-
QWQQ
L
FFQERYSETTLTDN
-----------
PD
F
LM
LA
S
A
F
G
IP
G
QH
I
TRKD
Q
VEA
AL
DTMLNS
---
DG
P
YL
L
HV
S
ID
EL
--------
E
NVW
P
L
V
PP
GA
S
N
S
EM
fig|216592.3.peg.4297
Escherichia coli 042 (7-543/548)
V
V
HA
L
RAQ
GV
NT
V
F
G
YP
G
GA
I
MP
V
Y
D
A
L
YDG
-
G
-
V
E
H
L
LC
RHEQ
G
A
AMA
A
I
G
Y
A
RAT
GK
T
GV
--
C
IAT
SGPG
A
TN
L
ITGLA
D
A
LL
D
SI
P
VV
A
I
T
G
QVSAPF
IG
--
T
D
A
FQE
V
D
VL
--------
GLSLACT
K
HSF
LV
QSL
E
E
LP
RI
M
AE
A
FDV
A
G
S
-
GRPG
P
V
L
VD
I
P
K
D
I
QLASGDLE
---
PWFTTVENEV---
-
-NFPHA-E
V
EQ
A
RQM
L
AK
A
QK
P
M
L
YV
G
G
G
VGM
A
Q
A
VPA
L
R
E
FLAATKM
P
VTCT
L
K
GLG
AV
E
AD
Y
P
YYL
GM
L
GM
H
G
TKAANFA
V
Q
EC
D
L
L
IA
VG
A
RF
DD
R
VTGKLNT
F
A
P
-
L
A
SV
IH
M
DIDP
A
E
M
NKLRQAH
VA
L
Q
GD
----
L
NA
LL
PA
L
Q-----Q
PL
N
-
I
ND
W
Q
Q
YCAQL
R
DEHTWRYD--HPG
D
----------------------------
A
-
IYAPLLLKQ
L
SD
----
RKPADCVV
T
T
DVG
QH
QM
W
AA
QH
-
IAHTR
P
E
NF
I
T
S
S
--------
GL
G
T
MG
F
GLP
A
A
V
GA
QV
A
R
P
NDT
VVC
IS
GDG
SFM
M
NVQ
E
LG
T
VK
R
KQ
LP
L
K
IV
LL
D
N
QR
LG
M
V
R
-
QWQQ
L
FFQERYSETTLTDN
-----------
PD
F
LM
LA
S
A
F
G
IP
G
QH
I
TRKD
Q
VEA
AL
DTMLNS
---
DG
P
YL
L
HV
S
ID
EL
--------
E
NVW
P
L
V
PP
GA
S
N
S
EM
fig|656379.3.peg.5002
Escherichia coli FVEC1302 (7-543/548)
V
V
HA
L
RAQ
GV
NT
V
F
G
YP
G
GA
I
MP
V
Y
D
A
L
YDG
-
G
-
V
E
H
L
LC
RHEQ
G
A
AMA
A
I
G
Y
A
RAT
GK
T
GV
--
C
IAT
SGPG
A
TN
L
ITGLA
D
A
LL
D
SI
P
VV
A
I
T
G
QVSAPF
IG
--
T
D
A
FQE
V
D
VL
--------
GLSLACT
K
HSF
LV
QSL
E
E
LP
RI
M
AE
A
FDV
A
G
S
-
GRPG
P
V
L
VD
I
P
K
D
I
QLASGDLE
---
PWFTTVENEV---
-
-NFPHA-E
V
EQ
A
RQM
L
AK
A
QK
P
M
L
YV
G
G
G
VGM
A
Q
A
VPA
L
R
E
FLAATKM
P
VTCT
L
K
GLG
AV
E
AD
Y
P
YYL
GM
L
GM
H
G
TKAANFA
V
Q
EC
D
L
L
IA
VG
A
RF
DD
R
VTGKLNT
F
A
P
-
L
A
SV
IH
M
DIDP
A
E
M
NKLRQAH
VA
L
Q
GD
----
L
NA
LL
PA
L
Q-----Q
PL
N
-
I
ND
W
Q
Q
YCAQL
R
DEHTWRYD--HPG
D
----------------------------
A
-
IYAPLLLKQ
L
SD
----
RKPADCVV
T
T
DVG
QH
QM
W
AA
QH
-
IAHTR
P
E
NF
I
T
S
S
--------
GL
G
T
MG
F
GLP
A
A
V
GA
QV
A
R
P
NDT
VVC
IS
GDG
SFM
M
NVQ
E
LG
T
VK
R
KQ
LP
L
K
IV
LL
D
N
QR
LG
M
V
R
-
QWQQ
L
FFQERYSETTLTDN
-----------
PD
F
LM
LA
S
A
F
G
IP
G
QH
I
TRKD
Q
VEA
AL
DTMLNS
---
DG
P
YL
L
HV
S
ID
EL
--------
E
NVW
P
L
V
PP
GA
S
N
S
EM
fig|656380.3.peg.4901
Escherichia coli FVEC1412 (7-543/548)
V
V
HA
L
RAQ
GV
NT
V
F
G
YP
G
GA
I
MP
V
Y
D
A
L
YDG
-
G
-
V
E
H
L
LC
RHEQ
G
A
AMA
A
I
G
Y
A
RAT
GK
T
GV
--
C
IAT
SGPG
A
TN
L
ITGLA
D
A
LL
D
SI
P
VV
A
I
T
G
QVSAPF
IG
--
T
D
A
FQE
V
D
VL
--------
GLSLACT
K
HSF
LV
QSL
E
E
LP
RI
M
AE
A
FDV
A
G
S
-
GRPG
P
V
L
VD
I
P
K
D
I
QLASGDLE
---
PWFTTVENEV---
-
-NFPHA-E
V
EQ
A
RQM
L
AK
A
QK
P
M
L
YV
G
G
G
VGM
A
Q
A
VPA
L
R
E
FLAATKM
P
VTCT
L
K
GLG
AV
E
AD
Y
P
YYL
GM
L
GM
H
G
TKAANFA
V
Q
EC
D
L
L
IA
VG
A
RF
DD
R
VTGKLNT
F
A
P
-
L
A
SV
IH
M
DIDP
A
E
M
NKLRQAH
VA
L
Q
GD
----
L
NA
LL
PA
L
Q-----Q
PL
N
-
I
ND
W
Q
Q
YCAQL
R
DEHTWRYD--HPG
D
----------------------------
A
-
IYAPLLLKQ
L
SD
----
RKPADCVV
T
T
DVG
QH
QM
W
AA
QH
-
IAHTR
P
E
NF
I
T
S
S
--------
GL
G
T
MG
F
GLP
A
A
V
GA
QV
A
R
P
NDT
VVC
IS
GDG
SFM
M
NVQ
E
LG
T
VK
R
KQ
LP
L
K
IV
LL
D
N
QR
LG
M
V
R
-
QWQQ
L
FFQERYSETTLTDN
-----------
PD
F
LM
LA
S
A
F
G
IP
G
QH
I
TRKD
Q
VEA
AL
DTMLNS
---
DG
P
YL
L
HV
S
ID
EL
--------
E
NVW
P
L
V
PP
GA
S
N
S
EM
fig|679207.4.peg.3711
Escherichia coli MS 107-1 (7-543/548)
V
V
HA
L
RAQ
GV
NT
V
F
G
YP
G
GA
I
MP
V
Y
D
A
L
YDG
-
G
-
V
E
H
L
LC
RHEQ
G
A
AMA
A
I
G
Y
A
RAT
GK
T
GV
--
C
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SGPG
A
TN
L
ITGLA
D
A
LL
D
SI
P
VV
A
I
T
G
QVSAPF
IG
--
T
D
A
FQE
V
D
VL
--------
GLSLACT
K
HSF
LV
QSL
E
E
LP
RI
M
AA
A
FDV
A
S
S
-
GRPG
P
V
L
VD
I
P
K
D
I
QLASGDLE
---
PWFTTVENEV---
-
-TFPHA-E
V
EQ
A
RQM
L
AK
A
QK
P
M
L
YV
G
G
G
VGM
A
Q
A
VPA
L
R
E
FLATTKM
P
ATCT
L
K
GLG
AV
E
AD
Y
P
YYL
GM
L
GM
H
G
TKAANFA
V
Q
EC
D
L
L
IA
VG
A
RF
DD
R
VTGKLNT
F
A
P
-
H
A
SV
IH
M
DIDP
A
E
M
NKLRQAH
VA
L
Q
GD
----
L
NA
LL
PA
L
Q-----Q
PL
N
-
I
ND
W
Q
Q
YCAQL
R
DEHTWRYD--HPG
D
----------------------------
A
-
IYAPLLLKQ
L
SD
----
RKPADCVV
T
T
DVG
QH
QM
W
AA
QH
-
IAHTR
P
E
NF
I
T
S
S
--------
GL
G
T
MG
F
GLP
A
A
V
GA
QV
A
R
P
NDT
VVC
IS
GDG
SFM
M
NVQ
E
LG
T
VK
R
KQ
LP
L
K
IV
LL
D
N
QR
LG
M
V
R
-
QWQQ
L
FFQERYSETTLTDN
-----------
PD
F
LM
LA
S
A
F
G
IP
G
QH
I
TRKD
Q
VEA
AL
DTMLNS
---
DG
P
YL
L
HV
S
ID
EF
--------
E
NVW
P
L
V
PP
GA
S
N
S
EM
fig|749549.3.peg.4402
Escherichia coli MS 198-1 (7-543/548)
V
V
HA
L
RAQ
GV
NT
V
F
G
YP
G
GA
I
MP
V
Y
D
A
L
YDG
-
G
-
V
E
H
L
LC
RHEQ
G
A
AMA
A
I
G
Y
A
RAT
GK
T
GV
--
C
IAT
SGPG
A
TN
L
ITGLA
D
A
LL
D
SI
P
VV
A
I
T
G
QVSAPF
IG
--
T
D
A
FQE
V
D
VL
--------
GLSLACT
K
HSF
LV
QSL
E
E
LP
RI
M
AE
A
FDV
A
G
S
-
GRPG
P
V
L
VD
I
P
K
D
I
QLASGDLE
---
PWFTTVENEV---
-
-NFPHA-E
V
EQ
A
RQM
L
AK
A
QK
P
M
L
YV
G
G
G
VGM
A
Q
A
VPA
L
R
E
FLAATKM
P
VTCT
L
K
GLG
AV
E
AD
Y
P
YYL
GM
L
GM
H
G
TKAANFA
V
Q
EC
D
L
L
IA
VG
A
RF
DD
R
VTGKLNT
F
A
P
-
L
A
SV
IH
M
DIDP
A
E
M
NKLRQAH
VA
L
Q
GD
----
L
NA
LL
PA
L
Q-----Q
PL
N
-
I
ND
W
Q
Q
YCAQL
R
DEHTWRYD--HPG
D
----------------------------
A
-
IYAPLLLKQ
L
SD
----
RKPADCVV
T
T
DVG
QH
QM
W
AA
QH
-
IAHTR
P
E
NF
I
T
S
S
--------
GL
G
T
MG
F
GLP
A
A
V
GA
QV
A
R
P
NDT
VVC
IS
GDG
SFM
M
NVQ
E
LG
T
VK
R
KQ
LP
L
K
IV
LL
D
N
QR
LG
M
V
R
-
QWQQ
L
FFQERYSETTLTDN
-----------
PD
F
LM
LA
S
A
F
G
IP
G
QH
I
TRKD
Q
VEA
AL
DTMLNS
---
DG
P
YL
L
HV
S
ID
EL
--------
E
NVW
P
L
V
PP
GA
S
N
S
EM
fig|585056.7.peg.4461
Escherichia coli UMN026 (7-543/548)
V
V
HA
L
RAQ
GV
NT
V
F
G
YP
G
GA
I
MP
V
Y
D
A
L
YDG
-
G
-
V
E
H
L
LC
RHEQ
G
A
AMA
A
I
G
Y
A
RAT
GK
T
GV
--
C
IAT
SGPG
A
TN
L
ITGLA
D
A
LL
D
SI
P
VV
A
I
T
G
QVSAPF
IG
--
T
D
A
FQE
V
D
VL
--------
GLSLACT
K
HSF
LV
QSL
E
E
LP
RI
M
AE
A
FDV
A
G
S
-
GRPG
P
V
L
VD
I
P
K
D
I
QLASGDLE
---
PWFTTVENEV---
-
-NFPHA-E
V
EQ
A
RQM
L
AK
A
QK
P
M
L
YV
G
G
G
VGM
A
Q
A
VPA
L
R
E
FLAATKM
P
VTCT
L
K
GLG
AV
E
AD
Y
P
YYL
GM
L
GM
H
G
TKAANFA
V
Q
EC
D
L
L
IA
VG
A
RF
DD
R
VTGKLNT
F
A
P
-
L
A
SV
IH
M
DIDP
A
E
M
NKLRQAH
VA
L
Q
GD
----
L
NA
LL
PA
L
Q-----Q
PL
N
-
I
ND
W
Q
Q
YCAQL
R
DEHTWRYD--HPG
D
----------------------------
A
-
IYAPLLLKQ
L
SD
----
RKPADCVV
T
T
DVG
QH
QM
W
AA
QH
-
IAHTR
P
E
NF
I
T
S
S
--------
GL
G
T
MG
F
GLP
A
A
V
GA
QV
A
R
P
NDT
VVC
IS
GDG
SFM
M
NVQ
E
LG
T
VK
R
KQ
LP
L
K
IV
LL
D
N
QR
LG
M
V
R
-
QWQQ
L
FFQERYSETTLTDN
-----------
PD
F
LM
LA
S
A
F
G
IP
G
QH
I
TRKD
Q
VEA
AL
DTMLNS
---
DG
P
YL
L
HV
S
ID
EL
--------
E
NVW
P
L
V
PP
GA
S
N
S
EM
fig|1040638.4.peg.1387
Escherichia coli O104:H4 str. LB226692 (7-543/548)
V
V
HA
L
RAQ
GV
NT
V
F
G
YP
G
GA
I
MP
V
Y
D
A
L
YDG
-
G
-
V
E
H
L
LC
RHEQ
G
A
AMA
A
I
G
Y
A
RAT
GK
T
GV
--
C
IAT
SGPG
A
TN
L
ITGLA
D
A
LL
D
SI
P
VV
A
I
T
G
QVSAPF
IG
--
T
D
A
FQE
V
D
VL
--------
GLSLACT
K
HSF
LV
QSL
E
E
LP
RI
M
AA
A
FDV
A
S
S
-
GRPG
P
V
L
VD
I
P
K
D
I
QLASGDLE
---
PWFTTVENEV---
-
-TFPHA-E
V
EQ
A
RQM
L
AK
A
QK
P
M
L
YV
G
G
G
VGM
A
Q
A
VPA
L
R
E
FLATTKM
P
ATCT
L
K
GLG
AV
E
AD
Y
P
YYL
GM
L
GM
H
G
TKAANFA
V
Q
EC
D
L
L
IA
VG
A
RF
DD
R
VTGKLNT
F
A
P
-
H
A
SV
IH
M
DIDP
A
E
M
NKLRQAH
VA
L
Q
GD
----
L
NA
LL
PA
L
Q-----Q
PL
N
-
I
ND
W
Q
Q
YCAQL
R
DEHTWRYD--HPG
D
----------------------------
A
-
IYAPLLLKQ
L
SD
----
RKPADCVV
T
T
DVG
QH
QM
W
AA
QH
-
IAHTR
P
E
NF
I
T
S
S
--------
GL
G
T
MG
F
GLP
A
A
V
GA
QV
A
R
P
NDT
VVC
IS
GDG
SFM
M
NVQ
E
LG
T
VK
R
KQ
LP
L
K
IV
LL
D
N
QR
LG
M
V
R
-
QWQQ
L
FFQERYSETTLTDN
-----------
PD
F
LM
LA
S
A
F
G
IP
G
QH
I
TRKD
Q
VEA
AL
DTMLNS
---
DG
P
YL
L
HV
S
ID
EL
--------
E
NVW
P
L
V
PP
GA
S
N
S
EM
fig|6666666.5357.peg.1120
Escherichia coli TY-2482 (7-543/548)
V
V
HA
L
RAQ
GV
NT
V
F
G
YP
G
GA
I
MP
V
Y
D
A
L
YDG
-
G
-
V
E
H
L
LC
RHEQ
G
A
AMA
A
I
G
Y
A
RAT
GK
T
GV
--
C
IAT
SGPG
A
TN
L
ITGLA
D
A
LL
D
SI
P
VV
A
I
T
G
QVSAPF
IG
--
T
D
A
FQE
V
D
VL
--------
GLSLACT
K
HSF
LV
QSL
E
E
LP
RI
M
AA
A
FDV
A
S
S
-
GRPG
P
V
L
VD
I
P
K
D
I
QLASGDLE
---
PWFTTVENEV---
-
-TFPHA-E
V
EQ
A
RQM
L
AK
A
QK
P
M
L
YV
G
G
G
VGM
A
Q
A
VPA
L
R
E
FLATTKM
P
ATCT
L
K
GLG
AV
E
AD
Y
P
YYL
GM
L
GM
H
G
TKAANFA
V
Q
EC
D
L
L
IA
VG
A
RF
DD
R
VTGKLNT
F
A
P
-
H
A
SV
IH
M
DIDP
A
E
M
NKLRQAH
VA
L
Q
GD
----
L
NA
LL
PA
L
Q-----Q
PL
N
-
I
ND
W
Q
Q
YCAQL
R
DEHTWRYD--HPG
D
----------------------------
A
-
IYAPLLLKQ
L
SD
----
RKPADCVV
T
T
DVG
QH
QM
W
AA
QH
-
IAHTR
P
E
NF
I
T
S
S
--------
GL
G
T
MG
F
GLP
A
A
V
GA
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A
R
P
NDT
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IS
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M
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E
LG
T
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R
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L
K
IV
LL
D
N
QR
LG
M
V
R
-
QWQQ
L
FFQERYSETTLTDN
-----------
PD
F
LM
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S
A
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G
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G
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VEA
AL
DTMLNS
---
DG
P
YL
L
HV
S
ID
EL
--------
E
NVW
P
L
V
PP
GA
S
N
S
EM
fig|585055.6.peg.4268
Escherichia coli 55989 (7-543/548)
V
V
HA
L
RAQ
GV
NT
V
F
G
YP
G
GA
I
MP
V
Y
D
A
L
YDG
-
G
-
V
E
H
L
LC
RHEQ
G
A
AMA
A
I
G
Y
A
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GK
T
GV
--
C
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SGPG
A
TN
L
ITGLA
D
A
LL
D
SI
P
VV
A
I
T
G
QVSAPF
IG
--
T
D
A
FQE
V
D
VL
--------
GLSLACT
K
HSF
LV
QSL
E
E
LP
RI
M
AA
A
FDV
A
S
S
-
GRPG
P
V
L
VD
I
P
K
D
I
QLASGDLE
---
PWFTTVENEV---
-
-TFPHA-E
V
EQ
A
RQM
L
AK
A
QK
P
M
L
YV
G
G
G
VGM
A
Q
A
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L
R
E
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P
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L
K
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AV
E
AD
Y
P
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GM
L
GM
H
G
TKAANFA
V
Q
EC
D
L
L
IA
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A
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R
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F
A
P
-
H
A
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IH
M
DIDP
A
E
M
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L
Q
GD
----
L
NA
LL
PA
L
Q-----Q
PL
N
-
I
ND
W
Q
Q
YCAQL
R
DEHTWRYD--HPG
D
----------------------------
A
-
IYAPLLLKQ
L
SD
----
RKPADCVV
T
T
DVG
QH
QM
W
AA
QH
-
IAHTR
P
E
NF
I
T
S
S
--------
GL
G
T
MG
F
GLP
A
A
V
GA
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A
R
P
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IS
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M
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E
LG
T
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R
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LP
L
K
IV
LL
D
N
QR
LG
M
V
R
-
QWQQ
L
FFQERYSETTLTDN
-----------
PD
F
LM
LA
S
A
F
G
IP
G
QH
I
TRKD
Q
VEA
AL
DTMLNS
---
DG
P
YL
L
HV
S
ID
EL
--------
E
NVW
P
L
V
PP
GA
S
N
S
EM
fig|585055.8.peg.4271
Escherichia coli 55989 (7-543/548)
V
V
HA
L
RAQ
GV
NT
V
F
G
YP
G
GA
I
MP
V
Y
D
A
L
YDG
-
G
-
V
E
H
L
LC
RHEQ
G
A
AMA
A
I
G
Y
A
RAT
GK
T
GV
--
C
IAT
SGPG
A
TN
L
ITGLA
D
A
LL
D
SI
P
VV
A
I
T
G
QVSAPF
IG
--
T
D
A
FQE
V
D
VL
--------
GLSLACT
K
HSF
LV
QSL
E
E
LP
RI
M
AA
A
FDV
A
S
S
-
GRPG
P
V
L
VD
I
P
K
D
I
QLASGDLE
---
PWFTTVENEV---
-
-TFPHA-E
V
EQ
A
RQM
L
AK
A
QK
P
M
L
YV
G
G
G
VGM
A
Q
A
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L
R
E
FLATTKM
P
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L
K
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AV
E
AD
Y
P
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L
GM
H
G
TKAANFA
V
Q
EC
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L
L
IA
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A
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A
P
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H
A
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IH
M
DIDP
A
E
M
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L
Q
GD
----
L
NA
LL
PA
L
Q-----Q
PL
N
-
I
ND
W
Q
Q
YCAQL
R
DEHTWRYD--HPG
D
----------------------------
A
-
IYAPLLLKQ
L
SD
----
RKPADCVV
T
T
DVG
QH
QM
W
AA
QH
-
IAHTR
P
E
NF
I
T
S
S
--------
GL
G
T
MG
F
GLP
A
A
V
GA
QV
A
R
P
NDT
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IS
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M
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E
LG
T
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R
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LP
L
K
IV
LL
D
N
QR
LG
M
V
R
-
QWQQ
L
FFQERYSETTLTDN
-----------
PD
F
LM
LA
S
A
F
G
IP
G
QH
I
TRKD
Q
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AL
DTMLNS
---
DG
P
YL
L
HV
S
ID
EL
--------
E
NVW
P
L
V
PP
GA
S
N
S
EM
fig|656437.3.peg.4248
Escherichia coli TA143 (7-543/548)
V
V
HA
L
RAQ
GV
NT
V
F
G
YP
G
GA
I
MP
V
Y
D
A
L
YDG
-
G
-
V
E
H
L
LC
RHEQ
G
A
AMA
A
I
G
Y
A
RAT
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T
GV
--
C
IAT
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TN
L
ITGLA
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A
LL
D
SI
P
VV
A
I
T
G
QVSAPF
IG
--
T
D
A
FQE
V
D
IL
--------
GLSLACT
K
HSF
LV
QSL
E
E
LP
RI
M
AE
A
FDV
A
S
S
-
GRPG
P
V
L
VD
I
P
K
D
I
QLASGDLE
---
PWFTTVENEV---
-
-NFPHA-E
V
EQ
A
RQM
L
AK
A
QK
P
M
L
YV
G
G
G
VGM
A
Q
A
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L
R
E
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K
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AD
Y
P
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GM
L
GM
H
G
TKAANFA
V
Q
EC
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L
L
IA
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A
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A
P
-
L
A
SV
IH
M
DIDP
A
E
M
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VA
L
Q
GD
----
L
NA
LL
PA
L
Q-----Q
PL
N
-
I
ND
W
Q
Q
YCAQL
R
DEHTWRYD--HPG
D
----------------------------
A
-
IYAPLLLKQ
L
SD
----
RKPADCVV
T
T
DVG
QH
QM
W
AA
QH
-
IVHTR
P
E
NF
I
T
S
S
--------
GL
G
T
MG
F
GLP
A
A
V
GA
QV
A
R
P
NDT
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IS
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M
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E
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T
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R
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LP
L
K
IV
LL
D
N
QR
LG
M
V
R
-
QWQQ
L
FFQERYSETTLTDN
-----------
PD
F
LM
LA
S
A
F
G
IP
G
QH
I
TRKD
Q
VEA
AL
DTMLNS
---
DG
P
YL
L
HV
S
ID
EL
--------
E
NVW
P
L
V
PP
GA
S
N
S
EM
fig|358709.5.peg.3385
Escherichia coli 101-1 (7-543/548)
V
V
HA
L
RAQ
GV
NT
V
F
G
YP
G
GA
I
MP
V
Y
D
A
L
YDG
-
G
-
V
E
H
L
LC
RHEQ
G
A
AMA
A
I
G
Y
A
RAT
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T
GV
--
C
IAT
SGPG
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TN
L
ITGLA
D
A
LL
D
SI
P
VV
A
I
T
G
QVSAPF
IG
--
T
D
A
FQE
V
D
VL
--------
GLSLACT
K
HSF
LV
QSL
E
E
LP
RI
M
AE
A
FDV
A
C
S
-
GRPG
P
V
L
VD
I
P
K
D
I
QLASGDLE
---
PWFTTVENEV---
-
-TFPHA-E
V
EQ
A
RQM
L
AK
A
QK
P
M
L
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G
G
G
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A
Q
A
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L
R
E
FLAATKM
P
ATCT
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K
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AV
E
AD
Y
P
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GM
L
GM
H
G
TKAANFA
V
Q
EC
D
L
L
IA
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A
P
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H
A
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IH
M
DIDP
A
E
M
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L
Q
GD
----
L
NA
LL
PA
L
Q-----Q
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N
-
I
ND
W
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L
HCAQL
R
DEHAWRYD--HPG
D
----------------------------
A
-
IYAPLLLKQ
L
SD
----
RKPADCVV
T
T
DVG
QH
QM
W
AA
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-
IAHTR
P
E
NF
I
T
S
S
--------
GL
G
T
MG
F
GLP
A
A
V
GA
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A
R
P
NDT
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IS
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M
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E
LG
T
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R
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LP
L
K
IV
LL
D
N
QR
LG
M
V
R
-
QWQQ
L
FFQERYSETTLTDN
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PD
F
LM
LA
S
A
F
G
IP
G
QH
I
TRKD
Q
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AL
DTMLNS
---
DG
P
YL
L
HV
S
ID
EL
--------
E
NVW
P
L
V
PP
GA
S
N
S
EM
fig|511693.5.peg.3844
Escherichia coli BL21 (7-543/548)
V
V
HA
L
RAQ
GV
NT
V
F
G
YP
G
GA
I
MP
V
Y
D
A
L
YDG
-
G
-
V
E
H
L
LC
RHEQ
G
A
AMA
A
I
G
Y
A
RAT
GK
T
GV
--
C
IAT
SGPG
A
TN
L
ITGLA
D
A
LL
D
SI
P
VV
A
I
T
G
QVSAPF
IG
--
T
D
A
FQE
V
D
VL
--------
GLSLACT
K
HSF
LV
QSL
E
E
LP
RI
M
AE
A
FDV
A
C
S
-
GRPG
P
V
L
VD
I
P
K
D
I
QLASGDLE
---
PWFTTVENEV---
-
-TFPHA-E
V
EQ
A
RQM
L
AK
A
QK
P
M
L
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G
G
G
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A
Q
A
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L
R
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P
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K
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AV
E
AD
Y
P
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GM
L
GM
H
G
TKAANFA
V
Q
EC
D
L
L
IA
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A
RF
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A
P
-
H
A
SV
IH
M
DIDP
A
E
M
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L
Q
GD
----
L
NA
LL
PA
L
Q-----Q
PL
N
-
I
ND
W
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L
HCAQL
R
DEHAWRYD--HPG
D
----------------------------
A
-
IYAPLLLKQ
L
SD
----
RKPADCVV
T
T
DVG
QH
QM
W
AA
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-
IAHTR
P
E
NF
I
T
S
S
--------
GL
G
T
MG
F
GLP
A
A
V
GA
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A
R
P
NDT
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IS
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SFM
M
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E
LG
T
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R
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LP
L
K
IV
LL
D
N
QR
LG
M
V
R
-
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L
FFQERYSETTLTDN
-----------
PD
F
LM
LA
S
A
F
G
IP
G
QH
I
TRKD
Q
VEA
AL
DTMLNS
---
DG
P
YL
L
HV
S
ID
EL
--------
E
NVW
P
L
V
PP
GA
S
N
S
EM
fig|469008.4.peg.4443
Escherichia coli BL21(DE3) (7-543/548)
V
V
HA
L
RAQ
GV
NT
V
F
G
YP
G
GA
I
MP
V
Y
D
A
L
YDG
-
G
-
V
E
H
L
LC
RHEQ
G
A
AMA
A
I
G
Y
A
RAT
GK
T
GV
--
C
IAT
SGPG
A
TN
L
ITGLA
D
A
LL
D
SI
P
VV
A
I
T
G
QVSAPF
IG
--
T
D
A
FQE
V
D
VL
--------
GLSLACT
K
HSF
LV
QSL
E
E
LP
RI
M
AE
A
FDV
A
C
S
-
GRPG
P
V
L
VD
I
P
K
D
I
QLASGDLE
---
PWFTTVENEV---
-
-TFPHA-E
V
EQ
A
RQM
L
AK
A
QK
P
M
L
YV
G
G
G
VGM
A
Q
A
VPA
L
R
E
FLAATKM
P
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L
K
GLG
AV
E
AD
Y
P
YYL
GM
L
GM
H
G
TKAANFA
V
Q
EC
D
L
L
IA
VG
A
RF
DD
R
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F
A
P
-
H
A
SV
IH
M
DIDP
A
E
M
NKLRQAH
VA
L
Q
GD
----
L
NA
LL
PA
L
Q-----Q
PL
N
-
I
ND
W
Q
L
HCAQL
R
DEHAWRYD--HPG
D
----------------------------
A
-
IYAPLLLKQ
L
SD
----
RKPADCVV
T
T
DVG
QH
QM
W
AA
QH
-
IAHTR
P
E
NF
I
T
S
S
--------
GL
G
T
MG
F
GLP
A
A
V
GA
QV
A
R
P
NDT
VVC
IS
GDG
SFM
M
NVQ
E
LG
T
VK
R
KQ
LP
L
K
IV
LL
D
N
QR
LG
M
V
R
-
QWQQ
L
FFQERYSETTLTDN
-----------
PD
F
LM
LA
S
A
F
G
IP
G
QH
I
TRKD
Q
VEA
AL
DTMLNS
---
DG
P
YL
L
HV
S
ID
EL
--------
E
NVW
P
L
V
PP
GA
S
N
S
EM
fig|749547.3.peg.2294
Escherichia coli MS 187-1 (7-543/548)
V
V
HA
L
RAQ
GV
NT
V
F
G
YP
G
GA
I
MP
V
Y
D
A
L
YDG
-
G
-
V
E
H
L
LC
RHEQ
G
A
AMA
A
I
G
Y
A
RAT
GK
T
GV
--
C
IAT
SGPG
A
TN
L
ITGLA
D
A
LL
D
SI
P
VV
A
I
T
G
QVSAPF
IG
--
T
D
A
FQE
V
D
VL
--------
GLSLACT
K
HSF
LV
QSL
E
E
LP
RI
M
AE
A
FDV
A
C
S
-
GRPG
P
V
L
VD
I
P
K
D
I
QLASGDLE
---
PWFTTVENEV---
-
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V
EQ
A
RQM
L
AK
A
QK
P
M
L
YV
G
G
G
VGM
A
Q
A
VPA
L
R
E
FLAATKM
P
ATCT
L
K
GLG
AV
E
AD
Y
P
YYL
GM
L
GM
H
G
TKAANFA
V
Q
EC
D
L
L
IA
VG
A
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DD
R
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F
A
P
-
H
A
SV
IH
M
DIDP
A
E
M
NKLRQAH
VA
L
Q
GD
----
L
NA
LL
PA
L
Q-----Q
PL
N
-
I
ND
W
Q
L
HCAQL
R
DEHAWRYD--HPG
D
----------------------------
A
-
IYAPLLLKQ
L
SD
----
RKPADCVV
T
T
DVG
QH
QM
W
AA
QH
-
IAHTR
P
E
NF
I
T
S
S
--------
GL
G
T
MG
F
GLP
A
A
V
GA
QV
A
R
P
NDT
VVC
IS
GDG
SFM
M
NVQ
E
LG
T
VK
R
KQ
LP
L
K
IV
LL
D
N
QR
LG
M
V
R
-
QWQQ
L
FFQERYSETTLTDN
-----------
PD
F
LM
LA
S
A
F
G
IP
G
QH
I
TRKD
Q
VEA
AL
DTMLNS
---
DG
P
YL
L
HV
S
ID
EL
--------
E
NVW
P
L
V
PP
GA
S
N
S
EM
fig|749527.3.peg.4539
Escherichia coli MS 21-1 (7-543/548)
V
V
HA
L
RAQ
GV
NT
V
F
G
YP
G
GA
I
MP
V
Y
D
A
L
YDG
-
G
-
M
E
H
L
LC
RHEQ
G
A
AMA
A
I
G
Y
A
RAT
GK
T
GV
--
C
IAT
SGPG
A
TN
L
ITGLA
D
A
LL
D
SI
P
VV
A
I
T
G
QVSAPF
IG
--
T
D
A
FQE
V
D
IL
--------
GLSLACT
K
HSF
LV
QSL
E
E
LP
RI
M
AE
A
FDV
A
S
S
-
GRPG
P
V
L
VD
I
P
K
D
I
QLASGDLE
---
PWFTTVENEV---
-
-TFPHA-E
V
EQ
A
RQM
L
AK
A
QK
P
M
L
YV
G
G
G
VGM
A
Q
A
VSA
L
R
E
FLATTKM
P
ATCT
L
K
GLG
AV
E
AD
Y
P
YYL
GM
L
GM
H
G
TKAANFA
V
Q
EC
D
L
L
IA
VG
A
RF
DD
R
VTGKLNT
F
A
P
-
H
A
SV
IH
M
DIDP
A
E
M
NKLRQAH
A
A
L
Q
GD
----
L
NA
LL
PA
L
Q-----Q
PL
N
-
I
DD
W
Q
Q
HCAQL
R
DEHAWRYD--HPG
D
----------------------------
A
-
IYAPLLLKQ
L
SD
----
RKPADCIV
T
T
DVG
QH
QM
W
AA
QH
-
IVHTR
P
E
NF
I
T
S
S
--------
GL
G
T
MG
F
GLP
A
A
V
GA
QV
A
R
P
NDT
VVC
IS
GDG
SFM
M
NVQ
E
LG
T
VK
R
KQ
LP
L
K
IV
LL
D
N
QR
LG
M
V
R
-
QWQQ
L
FFQERYSETTLTDN
-----------
PD
F
LM
LA
S
A
F
G
IP
G
QH
I
TRKD
Q
VEA
AL
DTMLNS
---
DG
P
YL
L
HV
S
ID
EL
--------
E
NVW
P
L
V
PP
GA
S
N
S
EM
fig|550676.3.peg.3975
Escherichia coli B185 (7-543/548)
V
V
HA
L
RAQ
GV
NT
V
F
G
YP
G
GA
I
MP
V
Y
D
A
L
YDG
-
G
-
V
E
H
L
LC
RHEQ
G
A
AMA
A
I
G
Y
A
RAT
GK
T
GV
--
C
IAT
SGPG
A
TN
L
ITGLA
D
A
LL
D
SI
P
VV
A
I
T
G
QVSAPF
IG
--
T
D
A
FQE
V
D
VL
--------
GLSLACT
K
HSF
LV
QSL
E
E
LP
RI
M
AE
A
FDV
A
S
S
-
GRPG
P
V
L
VD
I
P
K
D
I
QLASGDLE
---
PWFTTVENEV---
-
-TFPHA-E
V
EQ
A
RQM
L
AK
A
QK
P
M
L
YV
G
G
G
VGM
A
Q
A
VPA
L
R
E
FLSTTKM
P
ATCT
L
K
GLG
AV
E
AD
Y
P
YYL
GM
L
GM
H
G
TKAANFA
V
Q
EC
D
L
L
IA
VG
A
RF
DD
R
VTGKLNT
F
A
P
-
H
A
SV
IH
M
DIDP
A
E
M
NKLRQAH
VA
L
Q
GD
----
L
NA
LL
PA
L
Q-----Q
PL
N
-
I
ND
W
Q
L
HCAQL
R
DEHAWRYD--HPG
D
----------------------------
A
-
IYAPLLLKQ
L
SD
----
RKPADCVV
T
T
DVG
QH
QM
W
AA
QH
-
IAHTR
P
E
NF
I
T
S
S
--------
GL
G
T
MG
F
GLP
A
A
V
GA
QV
A
R
P
NDT
VVC
IS
GDG
SFM
M
NVQ
E
LG
T
VK
R
KQ
LP
L
K
IV
LL
D
N
QR
LG
M
V
R
-
QWQQ
L
FFQERYSETTLTDN
-----------
PD
F
LM
LA
S
A
F
G
IP
G
QH
I
TRKD
Q
VEA
AL
DTMLNS
---
DG
P
YL
L
HV
S
ID
EL
--------
E
NVW
P
L
V
PP
GA
S
N
S
EM
fig|409438.11.peg.4223
Escherichia coli SE11 (1-537/542)
M
V
HA
L
RAQ
GV
NT
V
F
G
YP
G
GA
I
MP
V
Y
D
A
L
YDG
-
G
-
V
E
H
L
LC
RHEQ
G
A
AMA
A
I
G
Y
A
RAT
GK
T
GV
--
C
IAT
SGPG
A
TN
L
ITGLA
D
A
LL
D
SI
P
VV
A
I
T
G
QVSAPF
IG
--
T
D
A
FQE
V
D
VL
--------
GLSLACT
K
HSF
LV
QSL
E
E
LP
RI
M
AA
A
FDV
A
S
S
-
GRPG
P
V
L
VD
I
P
K
D
I
QLASGDLE
---
PWFTTVENEV---
-
-TFPHA-E
V
EQ
A
RQM
L
AK
A
QK
P
M
L
YV
G
G
G
VGM
A
Q
A
VPA
L
R
E
FLATTKM
P
ATCT
L
K
GLG
AV
E
AD
Y
P
YYL
GM
L
GM
H
G
TKAANFA
V
Q
EC
D
L
L
IA
VG
A
RF
DD
R
VTGKLNT
F
A
P
-
H
A
SV
IH
M
DIDP
A
E
M
NKLRQAH
VA
L
Q
GD
----
L
NA
LL
PA
L
Q-----Q
PL
N
-
I
ND
W
Q
Q
YCAQL
R
DEHTWRYD--HPG
D
----------------------------
A
-
IYAPLLLKQ
L
SD
----
RKPADCVV
T
T
DVG
QH
QM
W
AA
QH
-
IAHTR
P
E
NF
I
T
S
S
--------
GL
G
T
MG
F
GLP
A
A
V
GA
QV
A
R
P
NDT
VVC
IS
GDG
SFM
M
NVQ
E
LG
T
VK
R
KQ
LP
L
K
IV
LL
D
N
QR
LG
M
V
R
-
QWQQ
L
FFQERYSETTLTDN
-----------
PD
F
LM
LA
S
A
F
G
IP
G
QH
I
TRKD
Q
VEA
AL
DTMLNS
---
DG
P
YL
L
HV
S
ID
EL
--------
E
NVW
P
L
V
PP
GA
S
N
S
EM
fig|340184.3.peg.1106
Escherichia coli B7A (7-543/548)
V
V
HA
L
RAQ
GV
NT
V
F
G
YP
G
GA
I
MP
V
Y
D
A
L
YDG
-
G
-
V
E
H
L
LC
RHEQ
G
A
AMA
A
I
G
Y
A
RAT
GK
T
GV
--
C
IAT
SGPG
A
TN
L
ITGLA
D
A
LL
D
SI
P
VV
A
I
T
G
QVSAPF
IG
--
T
D
A
FQE
V
D
VL
--------
GLSLACT
K
HSF
LV
QSL
E
E
LP
RI
M
AE
A
FDV
A
S
S
-
GRPG
P
V
L
VD
I
P
K
D
I
QLASGDLE
---
PWFTTVENEV---
-
-TFPHA-E
V
EQ
A
RQM
L
AK
A
QK
P
M
L
YV
G
G
G
VGM
A
Q
A
VPA
L
R
E
FLATTKM
P
ATCT
L
K
GLG
AV
E
AD
Y
P
YYL
GM
L
GM
H
G
TKAANFA
V
Q
EC
D
L
L
IA
VG
A
RF
DD
R
VTGKLNT
F
A
P
-
H
A
SV
IH
M
DIDP
A
E
M
NKLRQAH
VA
L
Q
GD
----
L
NA
LL
PA
L
Q-----Q
PL
N
-
I
ND
W
Q
L
HCAQL
R
DEHAWRYD--HPG
D
----------------------------
A
-
IYAPLLLKQ
L
SD
----
RKPADCVV
T
T
DVG
QH
QM
W
AA
QH
-
IAHTR
P
E
NF
I
T
S
S
--------
GL
G
T
MG
F
GLP
A
A
V
GA
QV
A
R
P
NDT
VVC
IS
GDG
SFM
M
NVQ
E
LG
T
VK
R
KQ
LP
L
K
IV
LL
D
N
QR
LG
M
V
R
-
QWQQ
L
FFQERYSETTLTDN
-----------
PD
F
LM
LA
S
A
F
G
IP
G
QH
I
TRKD
Q
VEA
AL
DTMLNS
---
DG
P
YL
L
HV
S
ID
EL
--------
E
NVW
P
L
V
PP
GA
S
N
S
EM
fig|340184.6.peg.1166
Escherichia coli B7A (7-543/548)
V
V
HA
L
RAQ
GV
NT
V
F
G
YP
G
GA
I
MP
V
Y
D
A
L
YDG
-
G
-
V
E
H
L
LC
RHEQ
G
A
AMA
A
I
G
Y
A
RAT
GK
T
GV
--
C
IAT
SGPG
A
TN
L
ITGLA
D
A
LL
D
SI
P
VV
A
I
T
G
QVSAPF
IG
--
T
D
A
FQE
V
D
VL
--------
GLSLACT
K
HSF
LV
QSL
E
E
LP
RI
M
AE
A
FDV
A
S
S
-
GRPG
P
V
L
VD
I
P
K
D
I
QLASGDLE
---
PWFTTVENEV---
-
-TFPHA-E
V
EQ
A
RQM
L
AK
A
QK
P
M
L
YV
G
G
G
VGM
A
Q
A
VPA
L
R
E
FLATTKM
P
ATCT
L
K
GLG
AV
E
AD
Y
P
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GM
L
GM
H
G
TKAANFA
V
Q
EC
D
L
L
IA
VG
A
RF
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R
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F
A
P
-
H
A
SV
IH
M
DIDP
A
E
M
NKLRQAH
VA
L
Q
GD
----
L
NA
LL
PA
L
Q-----Q
PL
N
-
I
ND
W
Q
L
HCAQL
R
DEHAWRYD--HPG
D
----------------------------
A
-
IYAPLLLKQ
L
SD
----
RKPADCVV
T
T
DVG
QH
QM
W
AA
QH
-
IAHTR
P
E
NF
I
T
S
S
--------
GL
G
T
MG
F
GLP
A
A
V
GA
QV
A
R
P
NDT
VVC
IS
GDG
SFM
M
NVQ
E
LG
T
VK
R
KQ
LP
L
K
IV
LL
D
N
QR
LG
M
V
R
-
QWQQ
L
FFQERYSETTLTDN
-----------
PD
F
LM
LA
S
A
F
G
IP
G
QH
I
TRKD
Q
VEA
AL
DTMLNS
---
DG
P
YL
L
HV
S
ID
EL
--------
E
NVW
P
L
V
PP
GA
S
N
S
EM
fig|340185.3.peg.4500
Escherichia coli E22 (7-543/548)
V
V
HA
L
RAQ
GV
NT
V
F
G
YP
G
GA
I
MP
V
Y
D
A
L
YDG
-
G
-
V
E
H
L
LC
RHEQ
G
A
AMA
A
I
G
Y
A
RAT
GK
T
GV
--
C
IAT
SGPG
A
TN
L
ITGLA
D
A
LL
D
SI
P
VV
A
I
T
G
QVSAPF
IG
--
T
D
A
FQE
V
D
VL
--------
GLSLACT
K
HSF
LV
QSL
E
E
LP
RI
M
AE
A
FDV
A
S
S
-
GRPG
P
V
L
VD
I
P
K
D
I
QLASGDLE
---
PWFTTVENEV---
-
-TFPHA-E
V
EQ
A
RQM
L
AK
A
QK
P
M
L
YV
G
G
G
VGM
A
Q
A
VPA
L
R
E
FLATTKM
P
ATCT
L
K
GLG
AV
E
AD
Y
P
YYL
GM
L
GM
H
G
TKAANFA
V
Q
EC
D
L
L
IA
VG
A
RF
DD
R
VTGKLNT
F
A
P
-
H
A
SV
IH
M
DIDP
A
E
M
NKLRQAH
VA
L
Q
GD
----
L
NA
LL
PA
L
Q-----Q
PL
N
-
I
ND
W
Q
L
HCAQL
R
DEHAWRYD--HPG
D
----------------------------
A
-
IYAPLLLKQ
L
SD
----
RKPADCVV
T
T
DVG
QH
QM
W
AA
QH
-
IAHTR
P
E
NF
I
T
S
S
--------
GL
G
T
MG
F
GLP
A
A
V
GA
QV
A
R
P
NDT
VVC
IS
GDG
SFM
M
NVQ
E
LG
T
VK
R
KQ
LP
L
K
IV
LL
D
N
QR
LG
M
V
R
-
QWQQ
L
FFQERYSETTLTDN
-----------
PD
F
LM
LA
S
A
F
G
IP
G
QH
I
TRKD
Q
VEA
AL
DTMLNS
---
DG
P
YL
L
HV
S
ID
EL
--------
E
NVW
P
L
V
PP
GA
S
N
S
EM
fig|340185.4.peg.4746
Escherichia coli E22 (7-543/548)
V
V
HA
L
RAQ
GV
NT
V
F
G
YP
G
GA
I
MP
V
Y
D
A
L
YDG
-
G
-
V
E
H
L
LC
RHEQ
G
A
AMA
A
I
G
Y
A
RAT
GK
T
GV
--
C
IAT
SGPG
A
TN
L
ITGLA
D
A
LL
D
SI
P
VV
A
I
T
G
QVSAPF
IG
--
T
D
A
FQE
V
D
VL
--------
GLSLACT
K
HSF
LV
QSL
E
E
LP
RI
M
AE
A
FDV
A
S
S
-
GRPG
P
V
L
VD
I
P
K
D
I
QLASGDLE
---
PWFTTVENEV---
-
-TFPHA-E
V
EQ
A
RQM
L
AK
A
QK
P
M
L
YV
G
G
G
VGM
A
Q
A
VPA
L
R
E
FLATTKM
P
ATCT
L
K
GLG
AV
E
AD
Y
P
YYL
GM
L
GM
H
G
TKAANFA
V
Q
EC
D
L
L
IA
VG
A
RF
DD
R
VTGKLNT
F
A
P
-
H
A
SV
IH
M
DIDP
A
E
M
NKLRQAH
VA
L
Q
GD
----
L
NA
LL
PA
L
Q-----Q
PL
N
-
I
ND
W
Q
L
HCAQL
R
DEHAWRYD--HPG
D
----------------------------
A
-
IYAPLLLKQ
L
SD
----
RKPADCVV
T
T
DVG
QH
QM
W
AA
QH
-
IAHTR
P
E
NF
I
T
S
S
--------
GL
G
T
MG
F
GLP
A
A
V
GA
QV
A
R
P
NDT
VVC
IS
GDG
SFM
M
NVQ
E
LG
T
VK
R
KQ
LP
L
K
IV
LL
D
N
QR
LG
M
V
R
-
QWQQ
L
FFQERYSETTLTDN
-----------
PD
F
LM
LA
S
A
F
G
IP
G
QH
I
TRKD
Q
VEA
AL
DTMLNS
---
DG
P
YL
L
HV
S
ID
EL
--------
E
NVW
P
L
V
PP
GA
S
N
S
EM
fig|595495.4.peg.3112
Escherichia coli KO11 (7-543/548)
V
V
HA
L
RAQ
GV
NT
V
F
G
YP
G
GA
I
MP
V
Y
D
A
L
YDG
-
G
-
V
E
H
L
LC
RHEQ
G
A
AMA
A
I
G
Y
A
RAT
GK
T
GV
--
C
IAT
SGPG
A
TN
L
ITGLA
D
A
LL
D
SI
P
VV
A
I
T
G
QVSAPF
IG
--
T
D
A
FQE
V
D
VL
--------
GLSLACT
K
HSF
LV
QSL
E
E
LP
RI
M
AE
A
FDV
A
S
S
-
GRPG
P
V
L
VD
I
P
K
D
I
QLASGDLE
---
PWFTTVENEV---
-
-TFPHA-E
V
EQ
A
RQM
L
AK
A
QK
P
M
L
YV
G
G
G
VGM
A
Q
A
VPA
L
R
E
FLATTKM
P
ATCT
L
K
GLG
AV
E
AD
Y
P
YYL
GM
L
GM
H
G
TKAANFA
V
Q
EC
D
L
L
IA
VG
A
RF
DD
R
VTGKLNT
F
A
P
-
H
A
SV
IH
M
DIDP
A
E
M
NKLRQAH
VA
L
Q
GD
----
L
NA
LL
PA
L
Q-----Q
PL
N
-
I
ND
W
Q
L
HCAQL
R
DEHAWRYD--HPG
D
----------------------------
A
-
IYAPLLLKQ
L
SD
----
RKPADCVV
T
T
DVG
QH
QM
W
AA
QH
-
IAHTR
P
E
NF
I
T
S
S
--------
GL
G
T
MG
F
GLP
A
A
V
GA
QV
A
R
P
NDT
VVC
IS
GDG
SFM
M
NVQ
E
LG
T
VK
R
KQ
LP
L
K
IV
LL
D
N
QR
LG
M
V
R
-
QWQQ
L
FFQERYSETTLTDN
-----------
PD
F
LM
LA
S
A
F
G
IP
G
QH
I
TRKD
Q
VEA
AL
DTMLNS
---
DG
P
YL
L
HV
S
ID
EL
--------
E
NVW
P
L
V
PP
GA
S
N
S
EM
fig|656419.3.peg.4857
Escherichia coli M718 (7-543/548)
V
V
HA
L
RAQ
GV
NT
V
F
G
YP
G
GA
I
MP
V
Y
D
A
L
YDG
-
G
-
V
E
H
L
LC
RHEQ
G
A
AMA
A
I
G
Y
A
RAT
GK
T
GV
--
C
IAT
SGPG
A
TN
L
ITGLA
D
A
LL
D
SI
P
VV
A
I
T
G
QVSAPF
IG
--
T
D
A
FQE
V
D
VL
--------
GLSLACT
K
HSF
LV
QSL
E
E
LP
RI
M
AE
A
FDV
A
S
S
-
GRPG
P
V
L
VD
I
P
K
D
I
QLASGDLE
---
PWFTTVENEV---
-
-TFPHA-E
V
EQ
A
RQM
L
AK
A
QK
P
M
L
YV
G
G
G
VGM
A
Q
A
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L
R
E
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P
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L
K
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AV
E
AD
Y
P
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GM
L
GM
H
G
TKAANFA
V
Q
EC
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L
L
IA
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A
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R
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A
P
-
H
A
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M
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A
E
M
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L
Q
GD
----
L
NA
LL
PA
L
Q-----Q
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N
-
I
ND
W
Q
L
HCAQL
R
DEHAWRYD--HPG
D
----------------------------
A
-
IYAPLLLKQ
L
SD
----
RKPADCVV
T
T
DVG
QH
QM
W
AA
QH
-
IAHTR
P
E
NF
I
T
S
S
--------
GL
G
T
MG
F
GLP
A
A
V
GA
QV
A
R
P
NDT
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IS
GDG
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M
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E
LG
T
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R
KQ
LP
L
K
IV
LL
D
N
QR
LG
M
V
R
-
QWQQ
L
FFQERYSETTLTDN
-----------
PD
F
LM
LA
S
A
F
G
IP
G
QH
I
TRKD
Q
VEA
AL
DTMLNS
---
DG
P
YL
L
HV
S
ID
EL
--------
E
NVW
P
L
V
PP
GA
S
N
S
EM
fig|679205.4.peg.2175
Escherichia coli MS 124-1 (7-543/548)
V
V
HA
L
RAQ
GV
NT
V
F
G
YP
G
GA
I
MP
V
Y
D
A
L
YDG
-
G
-
V
E
H
L
LC
RHEQ
G
A
AMA
A
I
G
Y
A
RAT
GK
T
GV
--
C
IAT
SGPG
A
TN
L
ITGLA
D
A
LL
D
SI
P
VV
A
I
T
G
QVSAPF
IG
--
T
D
A
FQE
V
D
VL
--------
GLSLACT
K
HSF
LV
QSL
E
E
LP
RI
M
AE
A
FDV
A
S
S
-
GRPG
P
V
L
VD
I
P
K
D
I
QLASGDLE
---
PWFTTVENEV---
-
-TFPHA-E
V
EQ
A
RQM
L
AK
A
QK
P
M
L
YV
G
G
G
VGM
A
Q
A
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L
R
E
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P
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L
K
GLG
AV
E
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Y
P
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GM
L
GM
H
G
TKAANFA
V
Q
EC
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L
L
IA
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A
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A
P
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H
A
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M
DIDP
A
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M
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L
Q
GD
----
L
NA
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PA
L
Q-----Q
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N
-
I
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W
Q
L
HCAQL
R
DEHAWRYD--HPG
D
----------------------------
A
-
IYAPLLLKQ
L
SD
----
RKPADCVV
T
T
DVG
QH
QM
W
AA
QH
-
IAHTR
P
E
NF
I
T
S
S
--------
GL
G
T
MG
F
GLP
A
A
V
GA
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A
R
P
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IS
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M
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E
LG
T
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R
KQ
LP
L
K
IV
LL
D
N
QR
LG
M
V
R
-
QWQQ
L
FFQERYSETTLTDN
-----------
PD
F
LM
LA
S
A
F
G
IP
G
QH
I
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VEA
AL
DTMLNS
---
DG
P
YL
L
HV
S
ID
EL
--------
E
NVW
P
L
V
PP
GA
S
N
S
EM
fig|679204.3.peg.3414
Escherichia coli MS 145-7 (7-543/548)
V
V
HA
L
RAQ
GV
NT
V
F
G
YP
G
GA
I
MP
V
Y
D
A
L
YDG
-
G
-
V
E
H
L
LC
RHEQ
G
A
AMA
A
I
G
Y
A
RAT
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T
GV
--
C
IAT
SGPG
A
TN
L
ITGLA
D
A
LL
D
SI
P
VV
A
I
T
G
QVSAPF
IG
--
T
D
A
FQE
V
D
VL
--------
GLSLACT
K
HSF
LV
QSL
E
E
LP
RI
M
AE
A
FDV
A
S
S
-
GRPG
P
V
L
VD
I
P
K
D
I
QLASGDLE
---
PWFTTVENEV---
-
-TFPHA-E
V
EQ
A
RQM
L
AK
A
QK
P
M
L
YV
G
G
G
VGM
A
Q
A
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L
R
E
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P
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L
K
GLG
AV
E
AD
Y
P
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L
GM
H
G
TKAANFA
V
Q
EC
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L
L
IA
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A
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A
P
-
H
A
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IH
M
DIDP
A
E
M
NKLRQAH
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L
Q
GD
----
L
NA
LL
PA
L
Q-----Q
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N
-
I
ND
W
Q
L
HCAQL
R
DEHAWRYD--HPG
D
----------------------------
A
-
IYAPLLLKQ
L
SD
----
RKPADCVV
T
T
DVG
QH
QM
W
AA
QH
-
IAHTR
P
E
NF
I
T
S
S
--------
GL
G
T
MG
F
GLP
A
A
V
GA
QV
A
R
P
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IS
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M
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E
LG
T
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R
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LP
L
K
IV
LL
D
N
QR
LG
M
V
R
-
QWQQ
L
FFQERYSETTLTDN
-----------
PD
F
LM
LA
S
A
F
G
IP
G
QH
I
TRKD
Q
VEA
AL
DTMLNS
---
DG
P
YL
L
HV
S
ID
EL
--------
E
NVW
P
L
V
PP
GA
S
N
S
EM
fig|749533.3.peg.2014
Escherichia coli MS 84-1 (7-543/548)
V
V
HA
L
RAQ
GV
NT
V
F
G
YP
G
GA
I
MP
V
Y
D
A
L
YDG
-
G
-
V
E
H
L
LC
RHEQ
G
A
AMA
A
I
G
Y
A
RAT
GK
T
GV
--
C
IAT
SGPG
A
TN
L
ITGLA
D
A
LL
D
SI
P
VV
A
I
T
G
QVSAPF
IG
--
T
D
A
FQE
V
D
VL
--------
GLSLACT
K
HSF
LV
QSL
E
E
LP
RI
M
AE
A
FDV
A
S
S
-
GRPG
P
V
L
VD
I
P
K
D
I
QLASGDLE
---
PWFTTVENEV---
-
-TFPHA-E
V
EQ
A
RQM
L
AK
A
QK
P
M
L
YV
G
G
G
VGM
A
Q
A
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L
R
E
FLATTKM
P
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L
K
GLG
AV
E
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Y
P
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GM
L
GM
H
G
TKAANFA
V
Q
EC
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L
L
IA
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A
P
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H
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M
DIDP
A
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M
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L
Q
GD
----
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NA
LL
PA
L
Q-----Q
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N
-
I
ND
W
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L
HCAQL
R
DEHAWRYD--HPG
D
----------------------------
A
-
IYAPLLLKQ
L
SD
----
RKPADCVV
T
T
DVG
QH
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W
AA
QH
-
IAHTR
P
E
NF
I
T
S
S
--------
GL
G
T
MG
F
GLP
A
A
V
GA
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A
R
P
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M
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T
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R
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LP
L
K
IV
LL
D
N
QR
LG
M
V
R
-
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L
FFQERYSETTLTDN
-----------
PD
F
LM
LA
S
A
F
G
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G
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I
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AL
DTMLNS
---
DG
P
YL
L
HV
S
ID
EL
--------
E
NVW
P
L
V
PP
GA
S
N
S
EM
fig|585395.4.peg.4602
Escherichia coli O103:H2 str. 12009 (7-543/548)
V
V
HA
L
RAQ
GV
NT
V
F
G
YP
G
GA
I
MP
V
Y
D
A
L
YDG
-
G
-
V
E
H
L
LC
RHEQ
G
A
AMA
A
I
G
Y
A
RAT
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T
GV
--
C
IAT
SGPG
A
TN
L
ITGLA
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A
LL
D
SI
P
VV
A
I
T
G
QVSAPF
IG
--
T
D
A
FQE
V
D
VL
--------
GLSLACT
K
HSF
LV
QSL
E
E
LP
RI
M
AE
A
FDV
A
S
S
-
GRPG
P
V
L
VD
I
P
K
D
I
QLASGDLE
---
PWFTTVENEV---
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-TFPHA-E
V
EQ
A
RQM
L
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A
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P
M
L
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G
G
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R
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L
K
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Y
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L
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H
G
TKAANFA
V
Q
EC
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L
L
IA
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M
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M
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L
Q
GD
----
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NA
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PA
L
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N
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W
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L
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R
DEHAWRYD--HPG
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----------------------------
A
-
IYAPLLLKQ
L
SD
----
RKPADCVV
T
T
DVG
QH
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W
AA
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P
E
NF
I
T
S
S
--------
GL
G
T
MG
F
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A
A
V
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A
R
P
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M
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T
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L
K
IV
LL
D
N
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LG
M
V
R
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L
FFQERYSETTLTDN
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F
LM
LA
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A
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G
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I
TRKD
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AL
DTMLNS
---
DG
P
YL
L
HV
S
ID
EL
--------
E
NVW
P
L
V
PP
GA
S
N
S
EM
fig|566546.3.peg.3653
Escherichia coli W (7-543/548)
V
V
HA
L
RAQ
GV
NT
V
F
G
YP
G
GA
I
MP
V
Y
D
A
L
YDG
-
G
-
V
E
H
L
LC
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G
A
AMA
A
I
G
Y
A
RAT
GK
T
GV
--
C
IAT
SGPG
A
TN
L
ITGLA
D
A
LL
D
SI
P
VV
A
I
T
G
QVSAPF
IG
--
T
D
A
FQE
V
D
VL
--------
GLSLACT
K
HSF
LV
QSL
E
E
LP
RI
M
AE
A
FDV
A
S
S
-
GRPG
P
V
L
VD
I
P
K
D
I
QLASGDLE
---
PWFTTVENEV---
-
-TFPHA-E
V
EQ
A
RQM
L
AK
A
QK
P
M
L
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G
G
G
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A
Q
A
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L
R
E
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P
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L
K
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AV
E
AD
Y
P
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GM
L
GM
H
G
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V
Q
EC
D
L
L
IA
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A
RF
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R
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A
P
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H
A
SV
IH
M
DIDP
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E
M
NKLRQAH
VA
L
Q
GD
----
L
NA
LL
PA
L
Q-----Q
PL
N
-
I
ND
W
Q
L
HCAQL
R
DEHAWRYD--HPG
D
----------------------------
A
-
IYAPLLLKQ
L
SD
----
RKPADCVV
T
T
DVG
QH
QM
W
AA
QH
-
IAHTR
P
E
NF
I
T
S
S
--------
GL
G
T
MG
F
GLP
A
A
V
GA
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A
R
P
NDT
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IS
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M
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E
LG
T
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R
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LP
L
K
IV
LL
D
N
QR
LG
M
V
R
-
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L
FFQERYSETTLTDN
-----------
PD
F
LM
LA
S
A
F
G
IP
G
QH
I
TRKD
Q
VEA
AL
DTMLNS
---
DG
P
YL
L
HV
S
ID
EL
--------
E
NVW
P
L
V
PP
GA
S
N
S
EM
fig|566546.4.peg.4016
Escherichia coli W (7-543/548)
V
V
HA
L
RAQ
GV
NT
V
F
G
YP
G
GA
I
MP
V
Y
D
A
L
YDG
-
G
-
V
E
H
L
LC
RHEQ
G
A
AMA
A
I
G
Y
A
RAT
GK
T
GV
--
C
IAT
SGPG
A
TN
L
ITGLA
D
A
LL
D
SI
P
VV
A
I
T
G
QVSAPF
IG
--
T
D
A
FQE
V
D
VL
--------
GLSLACT
K
HSF
LV
QSL
E
E
LP
RI
M
AE
A
FDV
A
S
S
-
GRPG
P
V
L
VD
I
P
K
D
I
QLASGDLE
---
PWFTTVENEV---
-
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V
EQ
A
RQM
L
AK
A
QK
P
M
L
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G
G
G
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A
Q
A
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L
R
E
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P
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L
K
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AV
E
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Y
P
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GM
L
GM
H
G
TKAANFA
V
Q
EC
D
L
L
IA
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A
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A
P
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H
A
SV
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M
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E
M
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VA
L
Q
GD
----
L
NA
LL
PA
L
Q-----Q
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N
-
I
ND
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Q
L
HCAQL
R
DEHAWRYD--HPG
D
----------------------------
A
-
IYAPLLLKQ
L
SD
----
RKPADCVV
T
T
DVG
QH
QM
W
AA
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-
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P
E
NF
I
T
S
S
--------
GL
G
T
MG
F
GLP
A
A
V
GA
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A
R
P
NDT
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IS
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M
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LG
T
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R
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LP
L
K
IV
LL
D
N
QR
LG
M
V
R
-
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L
FFQERYSETTLTDN
-----------
PD
F
LM
LA
S
A
F
G
IP
G
QH
I
TRKD
Q
VEA
AL
DTMLNS
---
DG
P
YL
L
HV
S
ID
EL
--------
E
NVW
P
L
V
PP
GA
S
N
S
EM
fig|413997.3.peg.3826
Escherichia coli B str. REL606 (1-537/542)
M
V
HA
L
RAQ
GV
NT
V
F
G
YP
G
GA
I
MP
V
Y
D
A
L
YDG
-
G
-
V
E
H
L
LC
RHEQ
G
A
AMA
A
I
G
Y
A
RAT
GK
T
GV
--
C
IAT
SGPG
A
TN
L
ITGLA
D
A
LL
D
SI
P
VV
A
I
T
G
QVSAPF
IG
--
T
D
A
FQE
V
D
VL
--------
GLSLACT
K
HSF
LV
QSL
E
E
LP
RI
M
AE
A
FDV
A
C
S
-
GRPG
P
V
L
VD
I
P
K
D
I
QLASGDLE
---
PWFTTVENEV---
-
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V
EQ
A
RQM
L
AK
A
QK
P
M
L
YV
G
G
G
VGM
A
Q
A
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L
R
E
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P
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L
K
GLG
AV
E
AD
Y
P
YYL
GM
L
GM
H
G
TKAANFA
V
Q
EC
D
L
L
IA
VG
A
RF
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A
P
-
H
A
SV
IH
M
DIDP
A
E
M
NKLRQAH
VA
L
Q
GD
----
L
NA
LL
PA
L
Q-----Q
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N
-
I
ND
W
Q
L
HCAQL
R
DEHAWRYD--HPG
D
----------------------------
A
-
IYAPLLLKQ
L
SD
----
RKPADCVV
T
T
DVG
QH
QM
W
AA
QH
-
IAHTR
P
E
NF
I
T
S
S
--------
GL
G
T
MG
F
GLP
A
A
V
GA
QV
A
R
P
NDT
VVC
IS
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SFM
M
NVQ
E
LG
T
VK
R
KQ
LP
L
K
IV
LL
D
N
QR
LG
M
V
R
-
QWQQ
L
FFQERYSETTLTDN
-----------
PD
F
LM
LA
S
A
F
G
IP
G
QH
I
TRKD
Q
VEA
AL
DTMLNS
---
DG
P
YL
L
HV
S
ID
EL
--------
E
NVW
P
L
V
PP
GA
S
N
S
EM
fig|562.375.peg.225
Escherichia coli EC4100B (7-543/548)
V
V
HA
L
RAQ
GV
NT
V
F
G
YP
G
GA
I
MP
V
Y
D
A
L
YDG
-
G
-
V
E
H
L
LC
RHEQ
G
A
AMA
A
I
G
Y
A
RAT
GK
T
GV
--
C
IAT
SGPG
A
TN
L
ITGLA
D
A
LL
D
SI
P
VV
A
I
T
G
QVSAPF
IG
--
T
D
A
FQE
V
D
VL
--------
GLSLACT
K
HSF
LV
QSL
E
E
LP
RI
M
AA
A
FDV
A
S
S
-
GRPG
P
V
L
VD
I
P
K
D
I
QLASGDLE
---
PWFTTVENEV---
-
-TFPHA-E
V
EQ
A
RQM
L
AK
A
QK
P
M
L
YV
G
G
G
VGM
A
Q
A
VPA
L
R
E
FLATTKM
P
ATCT
L
K
GLG
AV
E
AD
Y
P
YYL
GM
L
GM
H
G
TKAANFA
V
Q
EC
D
L
L
IA
VG
A
RF
DD
R
VTGKLNT
F
A
P
-
H
A
SV
IH
M
DIDP
A
E
M
NKLRQAH
VA
L
Q
GD
----
L
NA
LL
PA
L
Q-----Q
PL
N
-
I
ND
W
Q
Q
YCAQL
R
DEHTWCYD--HPG
D
----------------------------
A
-
IYAPLLLKQ
L
SD
----
RKPADCVV
T
T
DVG
QH
QM
W
AA
QH
-
IAHTR
P
E
NF
I
T
S
S
--------
GL
G
T
MG
F
GLP
A
A
V
GA
QV
A
R
P
NDT
VVC
IS
GDG
SFM
M
NVQ
E
LG
T
VK
R
KQ
LP
L
K
IV
LL
D
N
QR
LG
M
V
R
-
QWQQ
L
FFQERYSETTLTDN
-----------
PD
F
LM
LA
S
A
F
G
IP
G
QH
I
TRKD
Q
VEA
AL
DTMLNS
---
DG
P
YL
L
HV
S
ID
EL
--------
E
NVW
P
L
V
PP
GA
S
N
S
EM
fig|439855.10.peg.4270
Escherichia coli SMS-3-5 (7-543/548)
V
V
HA
L
RAQ
GV
NT
V
F
G
YP
G
GA
I
MP
V
Y
D
A
L
YDG
-
G
-
M
E
H
L
LC
RHEQ
G
A
AMA
A
I
G
Y
A
RAT
GK
T
GV
--
C
IAT
SGPG
A
TN
L
ITGLA
D
A
LL
D
SI
P
VV
A
I
T
G
QVSAPF
IG
--
T
D
A
FQE
V
D
IL
--------
GLSLACT
K
HSF
LV
QSL
E
E
LP
RI
M
AE
A
FDV
A
S
S
-
GRPG
P
V
L
VD
I
P
K
D
I
QLASGDLE
---
PWFTTVENEV---
-
-TFPHA-E
V
EQ
A
RQM
L
AK
A
QK
P
M
L
YV
G
G
G
VGM
A
Q
A
VPA
L
R
E
FLATTKM
P
ATCT
L
K
GLG
AV
E
AD
Y
P
YYL
GM
L
GM
H
G
TKAANFA
V
Q
EC
D
L
L
IA
VG
A
RF
DD
R
VTGKLNT
F
A
P
-
H
A
SV
IH
M
DIDP
A
E
M
NKLRQAH
A
A
L
Q
GD
----
L
NA
LL
PA
L
Q-----Q
PL
N
-
I
DD
W
Q
Q
HCAQL
R
DEHAWRYD--HPG
D
----------------------------
A
-
IYAPLLLKQ
L
SD
----
RKPADCIV
T
T
DVG
QH
QM
W
S
A
QH
-
IVHTR
P
E
NF
I
T
S
S
--------
GL
G
T
MG
F
GLP
A
A
V
GA
QV
A
R
P
NDT
VVC
IS
GDG
SFM
M
NVQ
E
LG
T
VK
R
KQ
LP
L
K
IV
LL
D
N
QR
LG
M
V
R
-
QWQQ
L
FFQERYSETTLTDN
-----------
PD
F
LM
LA
S
A
F
G
IP
G
QH
I
TRKD
Q
VEA
AL
DTMLNS
---
DG
P
YL
L
HV
S
ID
EL
--------
E
NVW
P
L
V
PP
GA
S
N
S
EM
fig|331111.3.peg.1914
Escherichia coli E24377A (7-543/548)
V
V
HA
L
RAQ
GV
NT
V
F
G
YP
G
GA
I
MP
V
Y
D
A
L
YDG
-
G
-
V
E
H
L
LC
RHEQ
G
A
AMA
A
I
G
Y
A
RAT
GK
T
GV
--
C
IAT
SGPG
A
TN
L
ITGLA
D
A
LL
D
SI
P
VV
A
I
T
G
QVSAPF
IG
--
T
D
A
FQE
V
D
VL
--------
GLSLACT
K
HSF
LV
QSL
E
E
LP
RI
M
AE
A
FDV
A
S
S
-
GRPG
P
V
L
VD
I
P
K
D
I
QLASGDLE
---
PWFTTVENEV---
-
-TFPHA-E
V
EQ
V
RQM
L
AK
A
QK
P
M
L
YV
G
G
G
VGM
A
Q
A
VPA
L
R
E
FLATTKM
P
ATCT
L
K
GLG
AV
E
AD
Y
P
YYL
GM
L
GM
H
G
TKAANFA
V
Q
EC
D
L
L
IA
VG
A
RF
DD
R
VTGKLNT
F
A
P
-
H
A
SV
IH
M
DIDP
A
E
M
NKLRQAH
VA
L
Q
GD
----
L
NA
LL
PA
L
Q-----Q
PL
N
-
I
ND
W
Q
L
HCAQL
R
DEHAWRYD--HPG
D
----------------------------
A
-
IYAPLLLKQ
L
SD
----
RKPADCVV
T
T
DVG
QH
QM
W
AA
QH
-
IAHTR
P
E
NF
I
T
S
S
--------
GL
G
T
MG
F
GLP
A
A
V
GA
QV
A
R
P
NDT
VVC
IS
GDG
SFM
M
NVQ
E
LG
T
VK
R
KQ
LP
L
K
IV
LL
D
N
QR
LG
M
V
R
-
QWQQ
L
FFQERYSETTLTDN
-----------
PD
F
LM
LA
S
A
F
G
IP
G
QH
I
TRKD
Q
VEA
AL
DTMLNS
---
DG
P
YL
L
HV
S
ID
EL
--------
E
NVW
P
L
V
PP
GA
S
N
S
EM
fig|656408.3.peg.4230
Escherichia coli H591 (7-543/548)
V
V
HA
L
RAQ
GV
NT
V
F
G
YP
G
GA
I
MP
V
Y
D
A
L
YDG
-
G
-
V
E
H
L
LC
RHEQ
G
A
AMA
A
I
G
Y
A
RAT
GK
T
GV
--
C
IAT
SGPG
A
TN
L
ITGLA
D
A
LL
D
SI
P
VV
A
I
T
G
QVSAPF
IG
--
T
D
A
FQE
V
D
VL
--------
GLSLACT
K
HSF
LV
QSL
E
E
LP
RI
M
AE
A
FDV
A
S
S
-
GRPG
P
V
L
VD
I
P
K
D
I
QLASGDLE
---
PWFTTVENEV---
-
-TFPHA-E
V
EQ
V
RQM
L
AK
A
QK
P
M
L
YV
G
G
G
VGM
A
Q
A
VPA
L
R
E
FLATTKM
P
ATCT
L
K
GLG
AV
E
AD
Y
P
YYL
GM
L
GM
H
G
TKAANFA
V
Q
EC
D
L
L
IA
VG
A
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R
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F
A
P
-
H
A
SV
IH
M
DIDP
A
E
M
NKLRQAH
VA
L
Q
GD
----
L
NA
LL
PA
L
Q-----Q
PL
N
-
I
ND
W
Q
L
HCAQL
R
DEHAWRYD--HPG
D
----------------------------
A
-
IYAPLLLKQ
L
SD
----
RKPADCVV
T
T
DVG
QH
QM
W
AA
QH
-
IAHTR
P
E
NF
I
T
S
S
--------
GL
G
T
MG
F
GLP
A
A
V
GA
QV
A
R
P
NDT
VVC
IS
GDG
SFM
M
NVQ
E
LG
T
VK
R
KQ
LP
L
K
IV
LL
D
N
QR
LG
M
V
R
-
QWQQ
L
FFQERYSETTLTDN
-----------
PD
F
LM
LA
S
A
F
G
IP
G
QH
I
TRKD
Q
VEA
AL
DTMLNS
---
DG
P
YL
L
HV
S
ID
EL
--------
E
NVW
P
L
V
PP
GA
S
N
S
EM
fig|679206.4.peg.4972
Escherichia coli MS 119-7 (7-543/548)
V
V
HA
L
RAQ
GV
NT
V
F
G
YP
G
GA
I
MP
V
Y
D
A
L
YDG
-
G
-
V
E
H
L
LC
RHEQ
G
A
AMA
A
I
G
Y
A
RAT
GK
T
GV
--
C
IAT
SGPG
A
TN
L
ITGLA
D
A
LL
D
SI
P
VV
A
I
T
G
QVSAPF
IG
--
T
D
A
FQE
V
D
VL
--------
GLSLACT
K
HSF
LV
QSL
E
E
LP
RI
M
AE
A
FDV
A
S
S
-
GRPG
P
V
L
VD
I
P
K
D
I
QLASGDLE
---
PWFTTVENEV---
-
-TFPHA-E
V
EQ
V
RQM
L
AK
A
QK
P
M
L
YV
G
G
G
VGM
A
Q
A
VPA
L
R
E
FLATTKM
P
ATCT
L
K
GLG
AV
E
AD
Y
P
YYL
GM
L
GM
H
G
TKAANFA
V
Q
EC
D
L
L
IA
VG
A
RF
DD
R
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F
A
P
-
H
A
SV
IH
M
DIDP
A
E
M
NKLRQAH
VA
L
Q
GD
----
L
NA
LL
PA
L
Q-----Q
PL
N
-
I
ND
W
Q
L
HCAQL
R
DEHAWRYD--HPG
D
----------------------------
A
-
IYAPLLLKQ
L
SD
----
RKPADCVV
T
T
DVG
QH
QM
W
AA
QH
-
IAHTR
P
E
NF
I
T
S
S
--------
GL
G
T
MG
F
GLP
A
A
V
GA
QV
A
R
P
NDT
VVC
IS
GDG
SFM
M
NVQ
E
LG
T
VK
R
KQ
LP
L
K
IV
LL
D
N
QR
LG
M
V
R
-
QWQQ
L
FFQERYSETTLTDN
-----------
PD
F
LM
LA
S
A
F
G
IP
G
QH
I
TRKD
Q
VEA
AL
DTMLNS
---
DG
P
YL
L
HV
S
ID
EL
--------
E
NVW
P
L
V
PP
GA
S
N
S
EM
fig|749545.3.peg.1400
Escherichia coli MS 182-1 (7-543/548)
V
V
HA
L
RAQ
GV
NT
V
F
G
YP
G
GA
I
MP
V
Y
D
A
L
YDG
-
G
-
V
E
H
L
LC
RHEQ
G
A
AMA
A
I
G
Y
A
RAT
GK
T
GV
--
C
IAT
SGPG
A
TN
L
ITGLA
D
A
LL
D
SI
P
VV
A
I
T
G
QVSAPF
IG
--
T
D
A
FQE
V
D
VL
--------
GLSLACT
K
HSF
LV
QSL
E
E
LP
RI
M
AE
A
FDV
A
S
S
-
GRPG
P
V
L
VD
I
P
K
D
I
QLASGDLE
---
PWFTTVENEV---
-
-TFPHA-E
V
EQ
V
RQM
L
AK
A
QK
P
M
L
YV
G
G
G
VGM
A
Q
A
VPA
L
R
E
FLATTKM
P
ATCT
L
K
GLG
AV
E
AD
Y
P
YYL
GM
L
GM
H
G
TKAANFA
V
Q
EC
D
L
L
IA
VG
A
RF
DD
R
VTGKLNT
F
A
P
-
H
A
SV
IH
M
DIDP
A
E
M
NKLRQAH
VA
L
Q
GD
----
L
NA
LL
PA
L
Q-----Q
PL
N
-
I
ND
W
Q
L
HCAQL
R
DEHAWRYD--HPG
D
----------------------------
A
-
IYAPLLLKQ
L
SD
----
RKPADCVV
T
T
DVG
QH
QM
W
AA
QH
-
IAHTR
P
E
NF
I
T
S
S
--------
GL
G
T
MG
F
GLP
A
A
V
GA
QV
A
R
P
NDT
VVC
IS
GDG
SFM
M
NVQ
E
LG
T
VK
R
KQ
LP
L
K
IV
LL
D
N
QR
LG
M
V
R
-
QWQQ
L
FFQERYSETTLTDN
-----------
PD
F
LM
LA
S
A
F
G
IP
G
QH
I
TRKD
Q
VEA
AL
DTMLNS
---
DG
P
YL
L
HV
S
ID
EL
--------
E
NVW
P
L
V
PP
GA
S
N
S
EM
fig|749532.3.peg.496
Escherichia coli MS 78-1 (7-543/548)
V
V
HA
L
RAQ
GV
NT
V
F
G
YP
G
GA
I
MP
V
Y
D
A
L
YDG
-
G
-
V
E
H
L
LC
RHEQ
G
A
AMA
A
I
G
Y
A
RAT
GK
T
GV
--
C
IAT
SGPG
A
TN
L
ITGLA
D
A
LL
D
SI
P
VV
A
I
T
G
QVSAPF
IG
--
T
D
A
FQE
V
D
VL
--------
GLSLACT
K
HSF
LV
QSL
E
E
LP
RI
M
AE
A
FDV
A
S
S
-
GRPG
P
V
L
VD
I
P
K
D
I
QLASGDLE
---
PWFTTVENEV---
-
-TFPHA-E
V
EQ
V
RQM
L
AK
A
QK
P
M
L
YV
G
G
G
VGM
A
Q
A
VPA
L
R
E
FLATTKM
P
ATCT
L
K
GLG
AV
E
AD
Y
P
YYL
GM
L
GM
H
G
TKAANFA
V
Q
EC
D
L
L
IA
VG
A
RF
DD
R
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F
A
P
-
H
A
SV
IH
M
DIDP
A
E
M
NKLRQAH
VA
L
Q
GD
----
L
NA
LL
PA
L
Q-----Q
PL
N
-
I
ND
W
Q
L
HCAQL
R
DEHAWRYD--HPG
D
----------------------------
A
-
IYAPLLLKQ
L
SD
----
RKPADCVV
T
T
DVG
QH
QM
W
AA
QH
-
IAHTR
P
E
NF
I
T
S
S
--------
GL
G
T
MG
F
GLP
A
A
V
GA
QV
A
R
P
NDT
VVC
IS
GDG
SFM
M
NVQ
E
LG
T
VK
R
KQ
LP
L
K
IV
LL
D
N
QR
LG
M
V
R
-
QWQQ
L
FFQERYSETTLTDN
-----------
PD
F
LM
LA
S
A
F
G
IP
G
QH
I
TRKD
Q
VEA
AL
DTMLNS
---
DG
P
YL
L
HV
S
ID
EL
--------
E
NVW
P
L
V
PP
GA
S
N
S
EM
fig|656443.3.peg.4709
Escherichia coli TA271 (7-543/548)
V
V
HA
L
RAQ
GV
NT
V
F
G
YP
G
GA
I
MP
V
Y
D
A
L
YDG
-
G
-
V
E
H
L
LC
RHEQ
G
A
AMA
A
I
G
Y
A
RAT
GK
T
GV
--
C
IAT
SGPG
A
TN
L
ITGLA
D
A
LL
D
SI
P
VV
A
I
T
G
QVSAPF
IG
--
T
D
A
FQE
V
D
VL
--------
GLSLACT
K
HSF
LV
QSL
E
E
LP
RI
M
AE
A
FDV
A
S
S
-
GRPG
P
V
L
VD
I
P
K
D
I
QLASGDLE
---
PWFTTVENEV---
-
-TFPHA-E
V
EQ
V
RQM
L
AK
A
QK
P
M
L
YV
G
G
G
VGM
A
Q
A
VPA
L
R
E
FLATTKM
P
ATCT
L
K
GLG
AV
E
AD
Y
P
YYL
GM
L
GM
H
G
TKAANFA
V
Q
EC
D
L
L
IA
VG
A
RF
DD
R
VTGKLNT
F
A
P
-
H
A
SV
IH
M
DIDP
A
E
M
NKLRQAH
VA
L
Q
GD
----
L
NA
LL
PA
L
Q-----Q
PL
N
-
I
ND
W
Q
L
HCAQL
R
DEHAWRYD--HPG
D
----------------------------
A
-
IYAPLLLKQ
L
SD
----
RKPADCVV
T
T
DVG
QH
QM
W
AA
QH
-
IAHTR
P
E
NF
I
T
S
S
--------
GL
G
T
MG
F
GLP
A
A
V
GA
QV
A
R
P
NDT
VVC
IS
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SFM
M
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E
LG
T
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R
KQ
LP
L
K
IV
LL
D
N
QR
LG
M
V
R
-
QWQQ
L
FFQERYSETTLTDN
-----------
PD
F
LM
LA
S
A
F
G
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G
QH
I
TRKD
Q
VEA
AL
DTMLNS
---
DG
P
YL
L
HV
S
ID
EL
--------
E
NVW
P
L
V
PP
GA
S
N
S
EM
fig|331111.12.peg.4513
Escherichia coli E24377A (1-537/542)
M
V
HA
L
RAQ
GV
NT
V
F
G
YP
G
GA
I
MP
V
Y
D
A
L
YDG
-
G
-
V
E
H
L
LC
RHEQ
G
A
AMA
A
I
G
Y
A
RAT
GK
T
GV
--
C
IAT
SGPG
A
TN
L
ITGLA
D
A
LL
D
SI
P
VV
A
I
T
G
QVSAPF
IG
--
T
D
A
FQE
V
D
VL
--------
GLSLACT
K
HSF
LV
QSL
E
E
LP
RI
M
AE
A
FDV
A
S
S
-
GRPG
P
V
L
VD
I
P
K
D
I
QLASGDLE
---
PWFTTVENEV---
-
-TFPHA-E
V
EQ
V
RQM
L
AK
A
QK
P
M
L
YV
G
G
G
VGM
A
Q
A
VPA
L
R
E
FLATTKM
P
ATCT
L
K
GLG
AV
E
AD
Y
P
YYL
GM
L
GM
H
G
TKAANFA
V
Q
EC
D
L
L
IA
VG
A
RF
DD
R
VTGKLNT
F
A
P
-
H
A
SV
IH
M
DIDP
A
E
M
NKLRQAH
VA
L
Q
GD
----
L
NA
LL
PA
L
Q-----Q
PL
N
-
I
ND
W
Q
L
HCAQL
R
DEHAWRYD--HPG
D
----------------------------
A
-
IYAPLLLKQ
L
SD
----
RKPADCVV
T
T
DVG
QH
QM
W
AA
QH
-
IAHTR
P
E
NF
I
T
S
S
--------
GL
G
T
MG
F
GLP
A
A
V
GA
QV
A
R
P
NDT
VVC
IS
GDG
SFM
M
NVQ
E
LG
T
VK
R
KQ
LP
L
K
IV
LL
D
N
QR
LG
M
V
R
-
QWQQ
L
FFQERYSETTLTDN
-----------
PD
F
LM
LA
S
A
F
G
IP
G
QH
I
TRKD
Q
VEA
AL
DTMLNS
---
DG
P
YL
L
HV
S
ID
EL
--------
E
NVW
P
L
V
PP
GA
S
N
S
EM
fig|550677.3.peg.4346
Escherichia coli B354 (7-543/548)
V
V
HA
L
RAQ
GV
NT
V
F
G
YP
G
GA
I
MP
V
Y
D
A
L
YDG
-
G
-
V
E
H
L
LC
RHEQ
G
A
AMA
A
I
G
Y
A
RAT
GK
T
GV
--
C
IAT
SGPG
A
TN
L
ITGLA
D
A
LL
D
SI
P
VV
A
I
T
G
QVSAPF
IG
--
T
D
A
FQE
V
D
VL
--------
GLSLACT
K
HSF
LV
QSL
E
E
LP
RI
M
AE
A
FDV
A
S
S
-
GRPG
P
V
L
VD
I
P
K
D
I
QLASGDLE
---
PWFTTVENEV---
-
-NFPHA-E
V
EQ
A
RQM
L
AK
A
QK
P
M
L
YV
G
G
G
VGM
A
Q
A
VPA
L
R
E
FLATAKM
P
ATCT
L
K
GLG
AV
E
AD
Y
P
YYL
GM
L
GM
H
G
TKAANFA
V
Q
EC
D
L
L
IA
VG
A
RF
DD
R
VTGKLNT
F
A
P
-
L
A
SV
IH
M
DIDP
A
E
M
NKLRQAH
VA
L
Q
G
N
----
L
NA
LL
PA
L
Q-----Q
PL
N
-
I
ND
W
Q
Q
YCAQL
R
DEHTWRYD--HPG
D
----------------------------
A
-
IYAPLLLKQ
L
SD
----
RKPADCVV
T
T
DVG
QH
QM
W
AA
QH
-
IAHTR
P
E
NF
I
T
S
S
--------
GL
G
T
MG
F
GLP
A
A
V
GA
QV
A
R
P
NDT
VVC
IS
GDG
SFM
M
NVQ
E
LG
T
VK
R
KQ
LP
L
K
IV
LL
D
N
QR
LG
M
V
R
-
QWQQ
L
FFQERYSETTLTDN
-----------
PD
F
LM
LA
S
A
F
G
IP
G
QH
I
TRKD
Q
VEA
AL
DTMLNS
---
DG
P
YL
L
HV
S
ID
EL
--------
E
NVW
P
L
V
PP
GA
S
N
S
EM
fig|749531.3.peg.2227
Escherichia coli MS 69-1 (7-543/548)
V
V
HA
L
RAQ
GV
NT
V
F
G
YP
G
GA
I
MP
V
Y
D
A
L
YDG
-
G
-
V
E
H
L
LC
RHEQ
G
A
AMA
A
I
G
Y
A
RAT
GK
T
GV
--
C
IAT
SGPG
A
TN
L
ITGLA
D
A
LL
D
SI
P
VV
A
I
T
G
QVSAPF
IG
--
T
D
A
FQE
V
D
VL
--------
GLSLACT
K
HSF
LV
QSL
E
E
LP
RI
M
AE
A
FDV
A
S
S
-
GRPG
P
V
L
VD
I
P
K
D
I
QLASGDLE
---
PWFTTVENEV---
-
-TFPHA-E
V
EQ
A
RQM
L
AK
A
QK
P
M
L
YV
G
G
G
VGM
A
Q
A
VSA
L
R
E
FLAATKM
P
ATCT
L
K
GLG
AV
E
AD
Y
P
YYL
GM
L
GM
H
G
TKAANFA
V
Q
EC
D
L
L
IA
VG
A
RF
DD
R
VTGKLNT
F
A
P
-
H
A
SV
IH
M
DIDP
A
E
M
NKLRQAH
VA
L
Q
GD
----
L
NA
LL
PA
L
L-----Q
PL
N
-
I
DD
W
Q
Q
HCAQL
R
DEHAWRYD--HPG
D
----------------------------
A
-
IYAPLLLKQ
L
SD
----
RKPADCIV
T
T
DVG
QH
QM
W
AA
QH
-
IVHTR
P
E
NF
I
T
S
S
--------
GL
G
T
MG
F
GLP
A
A
V
GA
QV
A
R
P
NDT
VVC
IS
GDG
SFM
M
NVQ
E
LG
T
VK
R
KQ
LP
L
K
IV
LL
D
N
QR
LG
M
V
R
-
QWQQ
L
FFQERYSETTLTDN
-----------
PD
F
LM
LA
S
A
F
G
IP
G
QH
I
TRKD
Q
VEA
AL
DTMLNS
---
DG
P
YL
L
HV
S
ID
EL
--------
E
NVW
P
L
V
PP
GA
S
N
S
EM
fig|316401.4.peg.4595
Escherichia coli ETEC H10407 (7-543/548)
V
V
HA
L
RAQ
GV
NT
V
F
G
YP
G
GA
I
MP
V
Y
D
A
L
YDG
-
G
-
V
E
H
L
LC
RHEQ
G
A
AIA
A
I
G
Y
A
RAT
GK
T
GV
--
C
IAT
SGPG
A
TN
L
ITGLA
D
A
LL
D
SI
P
VV
A
I
T
G
QVSAPF
IG
--
T
D
A
FQE
V
D
VL
--------
GLSLACT
K
HSF
LV
QSL
E
E
LP
RI
M
AE
A
FDV
A
C
S
-
GRPG
P
V
L
VD
I
P
K
D
I
QLASGDLE
---
PWFTTVENEV---
-
-TFPHA-E
V
EQ
A
RQM
L
AK
A
QK
P
M
L
YV
G
G
G
VGM
A
Q
A
VPA
L
R
E
FLAATKM
P
ATCT
L
K
GLG
AV
E
AD
Y
P
YYL
GM
L
GM
H
G
TKAANFA
V
Q
EC
D
L
L
IA
VG
A
RF
DD
R
VTGKLNT
F
A
P
-
H
A
SV
IH
M
DIDP
A
E
M
NKLRQAH
VA
L
Q
GD
----
L
NA
LL
PA
L
Q-----Q
PL
N
-
I
ND
W
Q
Q
HCAQL
R
DEHSWRYD--HPG
D
----------------------------
A
-
IYAPLLLKQ
L
SD
----
RKPADCVV
T
T
DVG
QH
QM
W
AA
QH
-
IAHTR
P
E
NF
I
T
S
S
--------
GL
G
T
MG
F
GLP
A
A
V
GA
QV
A
R
P
NDT
VVC
IS
GDG
SFM
M
NVQ
E
LG
T
VK
R
KQ
LP
L
K
IV
LL
D
N
QR
LG
M
V
R
-
QWQQ
L
FFQERYSETTLTDN
-----------
PD
F
LM
LA
S
A
F
G
IP
G
QH
I
TRKD
Q
VEA
AL
DTMLNS
---
DG
P
YL
L
HV
S
ID
EL
--------
E
NVW
P
L
V
PP
GA
S
N
S
EM
fig|216592.1.peg.1018
Escherichia coli 042 (19-559/562)
IV
HF
L
EQQ
G
I
KI
V
T
G
IP
G
GS
I
LP
V
Y
D
A
L
SQS
-
T
Q
I
R
HI
LA
RHEQ
G
A
GFI
A
Q
G
M
A
RTD
GK
P
A
V
--
C
MAC
SGPG
A
TN
L
V
T
AI
A
D
A
RL
D
SI
PLI
C
I
T
G
QVPASM
IG
--
T
D
A
FQE
V
D
TY
--------
GISIPIT
K
HNY
LV
RHI
E
E
LP
QV
M
SD
A
FRI
A
Q
S
-
GRPG
P
V
W
I
D
I
P
K
DV
QTAVFEIE
---
AQPAVAEKAVAP-
-
-AFSEE-S
I
RD
A
AAM
I
NA
A
KR
P
V
L
YL
G
G
G
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
TTMT
L
M
A
LG
ML
P
KA
HP
LSL
GM
L
GM
H
G
VRSTNYI
L
Q
E
AD
L
L
IV
L
G
A
RF
DD
R
AIGKTEQ
F
C
P
-
NA
KI
IH
V
DID
R
A
E
L
GKIKQPH
VAI
QA
D
VDDV
L
TQ
L
I
PL
V
EA----Q
P
R
A
--
-E
W
H
Q
LVADL
Q
REFPCPIP--KAC
D
----------------------------
P
-
LTHYGLINA
V
AA
----
CVDDSAII
T
T
DVG
QH
QM
W
T
A
QA
-
YPLNR
PR
QW
L
T
S
G
--------
GL
G
T
MG
F
GLP
A
AIGA
AL
A
N
P
DRK
V
L
C
FS
GDG
SLM
M
NIQ
E
MA
T
AS
E
NQ
L
D
V
K
I
I
LM
NN
EA
LG
L
V
H
-
QQQS
L
FYKQGVFAATYPGK
-----------
IN
F
MQ
I
A
A
G
F
G
LE
T
CD
L
NNEV
D
PQA
AL
QEIINR
---
PG
P
AL
IHV
R
ID
AE
--------
E
KVY
P
M
V
PP
GA
A
N
T
EM
fig|216592.3.peg.4179
Escherichia coli 042 (19-559/562)
IV
HF
L
EQQ
G
I
KI
V
T
G
IP
G
GS
I
LP
V
Y
D
A
L
SQS
-
T
Q
I
R
HI
LA
RHEQ
G
A
GFI
A
Q
G
M
A
RTD
GK
P
A
V
--
C
MAC
SGPG
A
TN
L
V
T
AI
A
D
A
RL
D
SI
PLI
C
I
T
G
QVPASM
IG
--
T
D
A
FQE
V
D
TY
--------
GISIPIT
K
HNY
LV
RHI
E
E
LP
QV
M
SD
A
FRI
A
Q
S
-
GRPG
P
V
W
I
D
I
P
K
DV
QTAVFEIE
---
AQPAVAEKAVAP-
-
-AFSEE-S
I
RD
A
AAM
I
NA
A
KR
P
V
L
YL
G
G
G
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
TTMT
L
M
A
LG
ML
P
KA
HP
LSL
GM
L
GM
H
G
VRSTNYI
L
Q
E
AD
L
L
IV
L
G
A
RF
DD
R
AIGKTEQ
F
C
P
-
NA
KI
IH
V
DID
R
A
E
L
GKIKQPH
VAI
QA
D
VDDV
L
TQ
L
I
PL
V
EA----Q
P
R
A
--
-E
W
H
Q
LVADL
Q
REFPCPIP--KAC
D
----------------------------
P
-
LTHYGLINA
V
AA
----
CVDDSAII
T
T
DVG
QH
QM
W
T
A
QA
-
YPLNR
PR
QW
L
T
S
G
--------
GL
G
T
MG
F
GLP
A
AIGA
AL
A
N
P
DRK
V
L
C
FS
GDG
SLM
M
NIQ
E
MA
T
AS
E
NQ
L
D
V
K
I
I
LM
NN
EA
LG
L
V
H
-
QQQS
L
FYKQGVFAATYPGK
-----------
IN
F
MQ
I
A
A
G
F
G
LE
T
CD
L
NNEV
D
PQA
AL
QEIINR
---
PG
P
AL
IHV
R
ID
AE
--------
E
KVY
P
M
V
PP
GA
A
N
T
EM
fig|562.371.peg.3055
Escherichia coli 1044A (19-559/562)
IV
HF
L
EQQ
G
I
KI
V
T
G
IP
G
GS
I
LP
V
Y
D
A
L
SQS
-
T
Q
I
R
HI
LA
RHEQ
G
A
GFI
A
Q
G
M
A
RTD
GK
P
A
V
--
C
MAC
SGPG
A
TN
L
V
T
AI
A
D
A
RL
D
SI
PLI
C
I
T
G
QVPASM
IG
--
T
D
A
FQE
V
D
TY
--------
GISIPIT
K
HNY
LV
RHI
E
E
LP
QV
M
SD
A
FRI
A
Q
S
-
GRPG
P
V
W
I
D
I
P
K
DV
QTAVFEIE
---
AQPAVAEKAVAP-
-
-AFSEE-S
I
RD
A
AAM
I
NA
A
KR
P
V
L
YL
G
G
G
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
TTMT
L
M
A
LG
ML
P
KA
HP
LSL
GM
L
GM
H
G
VRSTNYI
L
Q
E
AD
L
L
IV
L
G
A
RF
DD
R
AIGKTEQ
F
C
P
-
NA
KI
IH
V
DID
R
A
E
L
GKIKQPH
VAI
QA
D
VDDV
L
AQ
L
I
PQ
V
EA----Q
P
R
A
--
-E
W
H
Q
LVADL
Q
REFPCPIP--KAC
D
----------------------------
P
-
LSHYGLINA
V
AA
----
CVDDNAII
T
T
DVG
QH
QM
W
T
A
QA
-
YPLNR
PR
QW
L
T
S
G
--------
GL
G
T
MG
F
GLP
A
AIGA
AL
A
N
P
DRK
V
L
C
FS
GDG
SLM
M
NIQ
E
MA
T
AS
E
NQ
L
D
V
K
I
I
LM
NN
EA
LG
L
V
H
-
QQQS
L
FYKQGVFAATYPGK
-----------
IN
F
MQ
I
A
A
G
F
G
LE
T
CD
L
NNEA
D
PQA
AL
QEIINR
---
PG
P
AL
IHV
R
ID
AE
--------
E
KVY
P
M
V
PP
GA
A
N
T
EM
fig|562.373.peg.983
Escherichia coli 1125A (19-559/562)
IV
HF
L
EQQ
G
I
KI
V
T
G
IP
G
GS
I
LP
V
Y
D
A
L
SQS
-
T
Q
I
R
HI
LA
RHEQ
G
A
GFI
A
Q
G
M
A
RTD
GK
P
A
V
--
C
MAC
SGPG
A
TN
L
V
T
AI
A
D
A
RL
D
SI
PLI
C
I
T
G
QVPASM
IG
--
T
D
A
FQE
V
D
TY
--------
GISIPIT
K
HNY
LV
RHI
E
E
LP
QV
M
SD
A
FRI
A
Q
S
-
GRPG
P
V
W
I
D
I
P
K
DV
QTAVFEIE
---
AQPAVAEKAVAP-
-
-AFSEE-S
I
RD
A
AAM
I
NA
A
KR
P
V
L
YL
G
G
G
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
TTMT
L
M
A
LG
ML
P
KA
HP
LSL
GM
L
GM
H
G
VRSTNYI
L
Q
E
AD
L
L
IV
L
G
A
RF
DD
R
AIGKTEQ
F
C
P
-
NA
KI
IH
V
DID
R
A
E
L
GKIKQPH
VAI
QA
D
VDDV
L
AQ
L
I
PQ
V
EA----Q
P
R
A
--
-E
W
H
Q
LVADL
Q
REFPCPIP--KAC
D
----------------------------
P
-
LSHYGLINA
V
AA
----
CVDDNAII
T
T
DVG
QH
QM
W
T
A
QA
-
YPLNR
PR
QW
L
T
S
G
--------
GL
G
T
MG
F
GLP
A
AIGA
AL
A
N
P
DRK
V
L
C
FS
GDG
SLM
M
NIQ
E
MA
T
AS
E
NQ
L
D
V
K
I
I
LM
NN
EA
LG
L
V
H
-
QQQS
L
FYKQGVFAATYPGK
-----------
IN
F
MQ
I
A
A
G
F
G
LE
T
CD
L
NNEA
D
PQA
AL
QEIINR
---
PG
P
AL
IHV
R
ID
AE
--------
E
KVY
P
M
V
PP
GA
A
N
T
EM
fig|562.372.peg.3941
Escherichia coli 1212A (19-559/562)
IV
HF
L
EQQ
G
I
KI
V
T
G
IP
G
GS
I
LP
V
Y
D
A
L
SQS
-
T
Q
I
R
HI
LA
RHEQ
G
A
GFI
A
Q
G
M
A
RTD
GK
P
A
V
--
C
MAC
SGPG
A
TN
L
V
T
AI
A
D
A
RL
D
SI
PLI
C
I
T
G
QVPASM
IG
--
T
D
A
FQE
V
D
TY
--------
GISIPIT
K
HNY
LV
RHI
E
E
LP
QV
M
SD
A
FRI
A
Q
S
-
GRPG
P
V
W
I
D
I
P
K
DV
QTAVFEIE
---
AQPAVAEKAVAP-
-
-AFSEE-S
I
RD
A
AAM
I
NA
A
KR
P
V
L
YL
G
G
G
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
TTMT
L
M
A
LG
ML
P
KA
HP
LSL
GM
L
GM
H
G
VRSTNYI
L
Q
E
AD
L
L
IV
L
G
A
RF
DD
R
AIGKTEQ
F
C
P
-
NA
KI
IH
V
DID
R
A
E
L
GKIKQPH
VAI
QA
D
VDDV
L
AQ
L
I
PQ
V
EA----Q
P
R
A
--
-E
W
H
Q
LVADL
Q
REFPCPIP--KAC
D
----------------------------
P
-
LSHYGLINA
V
AA
----
CVDDNAII
T
T
DVG
QH
QM
W
T
A
QA
-
YPLNR
PR
QW
L
T
S
G
--------
GL
G
T
MG
F
GLP
A
AIGA
AL
A
N
P
DRK
V
L
C
FS
GDG
SLM
M
NIQ
E
MA
T
AS
E
NQ
L
D
V
K
I
I
LM
NN
EA
LG
L
V
H
-
QQQS
L
FYKQGVFAATYPGK
-----------
IN
F
MQ
I
A
A
G
F
G
LE
T
CD
L
NNEA
D
PQA
AL
QEIINR
---
PG
P
AL
IHV
R
ID
AE
--------
E
KVY
P
M
V
PP
GA
A
N
T
EM
fig|562.374.peg.2031
Escherichia coli 536A (19-559/562)
IV
HF
L
EQQ
G
I
KI
V
T
G
IP
G
GS
I
LP
V
Y
D
A
L
SQS
-
T
Q
I
R
HI
LA
RHEQ
G
A
GFI
A
Q
G
M
A
RTD
GK
P
A
V
--
C
MAC
SGPG
A
TN
L
V
T
AI
A
D
A
RL
D
SI
PLI
C
I
T
G
QVPASM
IG
--
T
D
A
FQE
V
D
TY
--------
GISIPIT
K
HNY
LV
RHI
E
E
LP
QV
M
SD
A
FRI
A
Q
S
-
GRPG
P
V
W
I
D
I
P
K
DV
QTAVFEIE
---
AQPAVAEKAVAP-
-
-AFSEE-S
I
RD
A
AAM
I
NA
A
KR
P
V
L
YL
G
G
G
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
TTMT
L
M
A
LG
ML
P
KA
HP
LSL
GM
L
GM
H
G
VRSTNYI
L
Q
E
AD
L
L
IV
L
G
A
RF
DD
R
AIGKTEQ
F
C
P
-
NA
KI
IH
V
DID
R
A
E
L
GKIKQPH
VAI
QA
D
VDDV
L
AQ
L
I
PQ
V
EA----Q
P
R
A
--
-E
W
H
Q
LVADL
Q
REFPCPIP--KAC
D
----------------------------
P
-
LSHYGLINA
V
AA
----
CVDDNAII
T
T
DVG
QH
QM
W
T
A
QA
-
YPLNR
PR
QW
L
T
S
G
--------
GL
G
T
MG
F
GLP
A
AIGA
AL
A
N
P
DRK
V
L
C
FS
GDG
SLM
M
NIQ
E
MA
T
AS
E
NQ
L
D
V
K
I
I
LM
NN
EA
LG
L
V
H
-
QQQS
L
FYKQGVFAATYPGK
-----------
IN
F
MQ
I
A
A
G
F
G
LE
T
CD
L
NNEA
D
PQA
AL
QEIINR
---
PG
P
AL
IHV
R
ID
AE
--------
E
KVY
P
M
V
PP
GA
A
N
T
EM
fig|749531.3.peg.334
Escherichia coli MS 69-1 (19-559/562)
IV
HF
L
EQQ
G
I
KI
V
T
G
IP
G
GS
I
LP
V
Y
D
A
L
SQS
-
T
Q
I
R
HI
LA
RHEQ
G
A
GFI
A
Q
G
M
A
RTD
GK
P
A
V
--
C
MAC
SGPG
A
TN
L
V
T
AI
A
D
A
RL
D
SI
PLI
C
I
T
G
QVPASM
IG
--
T
D
A
FQE
V
D
TY
--------
GISIPIT
K
HNY
LV
RHI
E
E
LP
QV
M
SD
A
FRI
A
Q
S
-
GRPG
P
V
W
I
D
I
P
K
DV
QTAVFEIE
---
AQPAVAEKAVAP-
-
-AFSEE-S
I
RD
A
AAM
I
NA
A
KR
P
V
L
YL
G
G
G
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
TTMT
L
M
A
LG
ML
P
KA
HP
LSL
GM
L
GM
H
G
VRSTNYI
L
Q
E
AD
L
L
IV
L
G
A
RF
DD
R
AIGKTEQ
F
C
P
-
NA
KI
IH
V
DID
R
A
E
L
GKIKQPH
VAI
QA
D
VDDV
L
AQ
L
I
PQ
V
EA----Q
P
R
A
--
-E
W
H
Q
LVADL
Q
REFPCPIP--KAC
D
----------------------------
P
-
LSHYGLINA
V
AA
----
CVDDNAII
T
T
DVG
QH
QM
W
T
A
QA
-
YPLNR
PR
QW
L
T
S
G
--------
GL
G
T
MG
F
GLP
A
AIGA
AL
A
N
P
DRK
V
L
C
FS
GDG
SLM
M
NIQ
E
MA
T
AS
E
NQ
L
D
V
K
I
I
LM
NN
EA
LG
L
V
H
-
QQQS
L
FYKQGVFAATYPGK
-----------
IN
F
MQ
I
A
A
G
F
G
LE
T
CD
L
NNEA
D
PQA
AL
QEIINR
---
PG
P
AL
IHV
R
ID
AE
--------
E
KVY
P
M
V
PP
GA
A
N
T
EM
fig|83334.1.peg.4582
Escherichia coli O157:H7 (19-559/562)
IV
HF
L
EQQ
G
I
KI
V
T
G
IP
G
GS
I
LP
V
Y
D
A
L
SQS
-
T
Q
I
R
HI
LA
RHEQ
G
A
GFI
A
Q
G
M
A
RTD
GK
P
A
V
--
C
MAC
SGPG
A
TN
L
V
T
AI
A
D
A
RL
D
SI
PLI
C
I
T
G
QVPASM
IG
--
T
D
A
FQE
V
D
TY
--------
GISIPIT
K
HNY
LV
RHI
E
E
LP
QV
M
SD
A
FRI
A
Q
S
-
GRPG
P
V
W
I
D
I
P
K
DV
QTAVFEIE
---
AQPAVAEKAVAP-
-
-AFSEE-S
I
RD
A
AAM
I
NA
A
KR
P
V
L
YL
G
G
G
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
TTMT
L
M
A
LG
ML
P
KA
HP
LSL
GM
L
GM
H
G
VRSTNYI
L
Q
E
AD
L
L
IV
L
G
A
RF
DD
R
AIGKTEQ
F
C
P
-
NA
KI
IH
V
DID
R
A
E
L
GKIKQPH
VAI
QA
D
VDDV
L
AQ
L
I
PQ
V
EA----Q
P
R
A
--
-E
W
H
Q
LVADL
Q
REFPCPIP--KAC
D
----------------------------
P
-
LSHYGLINA
V
AA
----
CVDDNAII
T
T
DVG
QH
QM
W
T
A
QA
-
YPLNR
PR
QW
L
T
S
G
--------
GL
G
T
MG
F
GLP
A
AIGA
AL
A
N
P
DRK
V
L
C
FS
GDG
SLM
M
NIQ
E
MA
T
AS
E
NQ
L
D
V
K
I
I
LM
NN
EA
LG
L
V
H
-
QQQS
L
FYKQGVFAATYPGK
-----------
IN
F
MQ
I
A
A
G
F
G
LE
T
CD
L
NNEA
D
PQA
AL
QEIINR
---
PG
P
AL
IHV
R
ID
AE
--------
E
KVY
P
M
V
PP
GA
A
N
T
EM
fig|444454.5.peg.3702
Escherichia coli O157:H7 str. EC4024 (19-559/562)
IV
HF
L
EQQ
G
I
KI
V
T
G
IP
G
GS
I
LP
V
Y
D
A
L
SQS
-
T
Q
I
R
HI
LA
RHEQ
G
A
GFI
A
Q
G
M
A
RTD
GK
P
A
V
--
C
MAC
SGPG
A
TN
L
V
T
AI
A
D
A
RL
D
SI
PLI
C
I
T
G
QVPASM
IG
--
T
D
A
FQE
V
D
TY
--------
GISIPIT
K
HNY
LV
RHI
E
E
LP
QV
M
SD
A
FRI
A
Q
S
-
GRPG
P
V
W
I
D
I
P
K
DV
QTAVFEIE
---
AQPAVAEKAVAP-
-
-AFSEE-S
I
RD
A
AAM
I
NA
A
KR
P
V
L
YL
G
G
G
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
TTMT
L
M
A
LG
ML
P
KA
HP
LSL
GM
L
GM
H
G
VRSTNYI
L
Q
E
AD
L
L
IV
L
G
A
RF
DD
R
AIGKTEQ
F
C
P
-
NA
KI
IH
V
DID
R
A
E
L
GKIKQPH
VAI
QA
D
VDDV
L
AQ
L
I
PQ
V
EA----Q
P
R
A
--
-E
W
H
Q
LVADL
Q
REFPCPIP--KAC
D
----------------------------
P
-
LSHYGLINA
V
AA
----
CVDDNAII
T
T
DVG
QH
QM
W
T
A
QA
-
YPLNR
PR
QW
L
T
S
G
--------
GL
G
T
MG
F
GLP
A
AIGA
AL
A
N
P
DRK
V
L
C
FS
GDG
SLM
M
NIQ
E
MA
T
AS
E
NQ
L
D
V
K
I
I
LM
NN
EA
LG
L
V
H
-
QQQS
L
FYKQGVFAATYPGK
-----------
IN
F
MQ
I
A
A
G
F
G
LE
T
CD
L
NNEA
D
PQA
AL
QEIINR
---
PG
P
AL
IHV
R
ID
AE
--------
E
KVY
P
M
V
PP
GA
A
N
T
EM
fig|444449.5.peg.3157
Escherichia coli O157:H7 str. EC4042 (19-559/562)
IV
HF
L
EQQ
G
I
KI
V
T
G
IP
G
GS
I
LP
V
Y
D
A
L
SQS
-
T
Q
I
R
HI
LA
RHEQ
G
A
GFI
A
Q
G
M
A
RTD
GK
P
A
V
--
C
MAC
SGPG
A
TN
L
V
T
AI
A
D
A
RL
D
SI
PLI
C
I
T
G
QVPASM
IG
--
T
D
A
FQE
V
D
TY
--------
GISIPIT
K
HNY
LV
RHI
E
E
LP
QV
M
SD
A
FRI
A
Q
S
-
GRPG
P
V
W
I
D
I
P
K
DV
QTAVFEIE
---
AQPAVAEKAVAP-
-
-AFSEE-S
I
RD
A
AAM
I
NA
A
KR
P
V
L
YL
G
G
G
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
TTMT
L
M
A
LG
ML
P
KA
HP
LSL
GM
L
GM
H
G
VRSTNYI
L
Q
E
AD
L
L
IV
L
G
A
RF
DD
R
AIGKTEQ
F
C
P
-
NA
KI
IH
V
DID
R
A
E
L
GKIKQPH
VAI
QA
D
VDDV
L
AQ
L
I
PQ
V
EA----Q
P
R
A
--
-E
W
H
Q
LVADL
Q
REFPCPIP--KAC
D
----------------------------
P
-
LSHYGLINA
V
AA
----
CVDDNAII
T
T
DVG
QH
QM
W
T
A
QA
-
YPLNR
PR
QW
L
T
S
G
--------
GL
G
T
MG
F
GLP
A
AIGA
AL
A
N
P
DRK
V
L
C
FS
GDG
SLM
M
NIQ
E
MA
T
AS
E
NQ
L
D
V
K
I
I
LM
NN
EA
LG
L
V
H
-
QQQS
L
FYKQGVFAATYPGK
-----------
IN
F
MQ
I
A
A
G
F
G
LE
T
CD
L
NNEA
D
PQA
AL
QEIINR
---
PG
P
AL
IHV
R
ID
AE
--------
E
KVY
P
M
V
PP
GA
A
N
T
EM
fig|444448.5.peg.1913
Escherichia coli O157:H7 str. EC4045 (19-559/562)
IV
HF
L
EQQ
G
I
KI
V
T
G
IP
G
GS
I
LP
V
Y
D
A
L
SQS
-
T
Q
I
R
HI
LA
RHEQ
G
A
GFI
A
Q
G
M
A
RTD
GK
P
A
V
--
C
MAC
SGPG
A
TN
L
V
T
AI
A
D
A
RL
D
SI
PLI
C
I
T
G
QVPASM
IG
--
T
D
A
FQE
V
D
TY
--------
GISIPIT
K
HNY
LV
RHI
E
E
LP
QV
M
SD
A
FRI
A
Q
S
-
GRPG
P
V
W
I
D
I
P
K
DV
QTAVFEIE
---
AQPAVAEKAVAP-
-
-AFSEE-S
I
RD
A
AAM
I
NA
A
KR
P
V
L
YL
G
G
G
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
TTMT
L
M
A
LG
ML
P
KA
HP
LSL
GM
L
GM
H
G
VRSTNYI
L
Q
E
AD
L
L
IV
L
G
A
RF
DD
R
AIGKTEQ
F
C
P
-
NA
KI
IH
V
DID
R
A
E
L
GKIKQPH
VAI
QA
D
VDDV
L
AQ
L
I
PQ
V
EA----Q
P
R
A
--
-E
W
H
Q
LVADL
Q
REFPCPIP--KAC
D
----------------------------
P
-
LSHYGLINA
V
AA
----
CVDDNAII
T
T
DVG
QH
QM
W
T
A
QA
-
YPLNR
PR
QW
L
T
S
G
--------
GL
G
T
MG
F
GLP
A
AIGA
AL
A
N
P
DRK
V
L
C
FS
GDG
SLM
M
NIQ
E
MA
T
AS
E
NQ
L
D
V
K
I
I
LM
NN
EA
LG
L
V
H
-
QQQS
L
FYKQGVFAATYPGK
-----------
IN
F
MQ
I
A
A
G
F
G
LE
T
CD
L
NNEA
D
PQA
AL
QEIINR
---
PG
P
AL
IHV
R
ID
AE
--------
E
KVY
P
M
V
PP
GA
A
N
T
EM
fig|444453.5.peg.1442
Escherichia coli O157:H7 str. EC4076 (19-559/562)
IV
HF
L
EQQ
G
I
KI
V
T
G
IP
G
GS
I
LP
V
Y
D
A
L
SQS
-
T
Q
I
R
HI
LA
RHEQ
G
A
GFI
A
Q
G
M
A
RTD
GK
P
A
V
--
C
MAC
SGPG
A
TN
L
V
T
AI
A
D
A
RL
D
SI
PLI
C
I
T
G
QVPASM
IG
--
T
D
A
FQE
V
D
TY
--------
GISIPIT
K
HNY
LV
RHI
E
E
LP
QV
M
SD
A
FRI
A
Q
S
-
GRPG
P
V
W
I
D
I
P
K
DV
QTAVFEIE
---
AQPAVAEKAVAP-
-
-AFSEE-S
I
RD
A
AAM
I
NA
A
KR
P
V
L
YL
G
G
G
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
TTMT
L
M
A
LG
ML
P
KA
HP
LSL
GM
L
GM
H
G
VRSTNYI
L
Q
E
AD
L
L
IV
L
G
A
RF
DD
R
AIGKTEQ
F
C
P
-
NA
KI
IH
V
DID
R
A
E
L
GKIKQPH
VAI
QA
D
VDDV
L
AQ
L
I
PQ
V
EA----Q
P
R
A
--
-E
W
H
Q
LVADL
Q
REFPCPIP--KAC
D
----------------------------
P
-
LSHYGLINA
V
AA
----
CVDDNAII
T
T
DVG
QH
QM
W
T
A
QA
-
YPLNR
PR
QW
L
T
S
G
--------
GL
G
T
MG
F
GLP
A
AIGA
AL
A
N
P
DRK
V
L
C
FS
GDG
SLM
M
NIQ
E
MA
T
AS
E
NQ
L
D
V
K
I
I
LM
NN
EA
LG
L
V
H
-
QQQS
L
FYKQGVFAATYPGK
-----------
IN
F
MQ
I
A
A
G
F
G
LE
T
CD
L
NNEA
D
PQA
AL
QEIINR
---
PG
P
AL
IHV
R
ID
AE
--------
E
KVY
P
M
V
PP
GA
A
N
T
EM
fig|444452.5.peg.1656
Escherichia coli O157:H7 str. EC4113 (19-559/562)
IV
HF
L
EQQ
G
I
KI
V
T
G
IP
G
GS
I
LP
V
Y
D
A
L
SQS
-
T
Q
I
R
HI
LA
RHEQ
G
A
GFI
A
Q
G
M
A
RTD
GK
P
A
V
--
C
MAC
SGPG
A
TN
L
V
T
AI
A
D
A
RL
D
SI
PLI
C
I
T
G
QVPASM
IG
--
T
D
A
FQE
V
D
TY
--------
GISIPIT
K
HNY
LV
RHI
E
E
LP
QV
M
SD
A
FRI
A
Q
S
-
GRPG
P
V
W
I
D
I
P
K
DV
QTAVFEIE
---
AQPAVAEKAVAP-
-
-AFSEE-S
I
RD
A
AAM
I
NA
A
KR
P
V
L
YL
G
G
G
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
TTMT
L
M
A
LG
ML
P
KA
HP
LSL
GM
L
GM
H
G
VRSTNYI
L
Q
E
AD
L
L
IV
L
G
A
RF
DD
R
AIGKTEQ
F
C
P
-
NA
KI
IH
V
DID
R
A
E
L
GKIKQPH
VAI
QA
D
VDDV
L
AQ
L
I
PQ
V
EA----Q
P
R
A
--
-E
W
H
Q
LVADL
Q
REFPCPIP--KAC
D
----------------------------
P
-
LSHYGLINA
V
AA
----
CVDDNAII
T
T
DVG
QH
QM
W
T
A
QA
-
YPLNR
PR
QW
L
T
S
G
--------
GL
G
T
MG
F
GLP
A
AIGA
AL
A
N
P
DRK
V
L
C
FS
GDG
SLM
M
NIQ
E
MA
T
AS
E
NQ
L
D
V
K
I
I
LM
NN
EA
LG
L
V
H
-
QQQS
L
FYKQGVFAATYPGK
-----------
IN
F
MQ
I
A
A
G
F
G
LE
T
CD
L
NNEA
D
PQA
AL
QEIINR
---
PG
P
AL
IHV
R
ID
AE
--------
E
KVY
P
M
V
PP
GA
A
N
T
EM
fig|444450.8.peg.4994
Escherichia coli O157:H7 str. EC4115 (19-559/562)
IV
HF
L
EQQ
G
I
KI
V
T
G
IP
G
GS
I
LP
V
Y
D
A
L
SQS
-
T
Q
I
R
HI
LA
RHEQ
G
A
GFI
A
Q
G
M
A
RTD
GK
P
A
V
--
C
MAC
SGPG
A
TN
L
V
T
AI
A
D
A
RL
D
SI
PLI
C
I
T
G
QVPASM
IG
--
T
D
A
FQE
V
D
TY
--------
GISIPIT
K
HNY
LV
RHI
E
E
LP
QV
M
SD
A
FRI
A
Q
S
-
GRPG
P
V
W
I
D
I
P
K
DV
QTAVFEIE
---
AQPAVAEKAVAP-
-
-AFSEE-S
I
RD
A
AAM
I
NA
A
KR
P
V
L
YL
G
G
G
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
TTMT
L
M
A
LG
ML
P
KA
HP
LSL
GM
L
GM
H
G
VRSTNYI
L
Q
E
AD
L
L
IV
L
G
A
RF
DD
R
AIGKTEQ
F
C
P
-
NA
KI
IH
V
DID
R
A
E
L
GKIKQPH
VAI
QA
D
VDDV
L
AQ
L
I
PQ
V
EA----Q
P
R
A
--
-E
W
H
Q
LVADL
Q
REFPCPIP--KAC
D
----------------------------
P
-
LSHYGLINA
V
AA
----
CVDDNAII
T
T
DVG
QH
QM
W
T
A
QA
-
YPLNR
PR
QW
L
T
S
G
--------
GL
G
T
MG
F
GLP
A
AIGA
AL
A
N
P
DRK
V
L
C
FS
GDG
SLM
M
NIQ
E
MA
T
AS
E
NQ
L
D
V
K
I
I
LM
NN
EA
LG
L
V
H
-
QQQS
L
FYKQGVFAATYPGK
-----------
IN
F
MQ
I
A
A
G
F
G
LE
T
CD
L
NNEA
D
PQA
AL
QEIINR
---
PG
P
AL
IHV
R
ID
AE
--------
E
KVY
P
M
V
PP
GA
A
N
T
EM
fig|444451.5.peg.72
Escherichia coli O157:H7 str. EC4196 (19-559/562)
IV
HF
L
EQQ
G
I
KI
V
T
G
IP
G
GS
I
LP
V
Y
D
A
L
SQS
-
T
Q
I
R
HI
LA
RHEQ
G
A
GFI
A
Q
G
M
A
RTD
GK
P
A
V
--
C
MAC
SGPG
A
TN
L
V
T
AI
A
D
A
RL
D
SI
PLI
C
I
T
G
QVPASM
IG
--
T
D
A
FQE
V
D
TY
--------
GISIPIT
K
HNY
LV
RHI
E
E
LP
QV
M
SD
A
FRI
A
Q
S
-
GRPG
P
V
W
I
D
I
P
K
DV
QTAVFEIE
---
AQPAVAEKAVAP-
-
-AFSEE-S
I
RD
A
AAM
I
NA
A
KR
P
V
L
YL
G
G
G
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
TTMT
L
M
A
LG
ML
P
KA
HP
LSL
GM
L
GM
H
G
VRSTNYI
L
Q
E
AD
L
L
IV
L
G
A
RF
DD
R
AIGKTEQ
F
C
P
-
NA
KI
IH
V
DID
R
A
E
L
GKIKQPH
VAI
QA
D
VDDV
L
AQ
L
I
PQ
V
EA----Q
P
R
A
--
-E
W
H
Q
LVADL
Q
REFPCPIP--KAC
D
----------------------------
P
-
LSHYGLINA
V
AA
----
CVDDNAII
T
T
DVG
QH
QM
W
T
A
QA
-
YPLNR
PR
QW
L
T
S
G
--------
GL
G
T
MG
F
GLP
A
AIGA
AL
A
N
P
DRK
V
L
C
FS
GDG
SLM
M
NIQ
E
MA
T
AS
E
NQ
L
D
V
K
I
I
LM
NN
EA
LG
L
V
H
-
QQQS
L
FYKQGVFAATYPGK
-----------
IN
F
MQ
I
A
A
G
F
G
LE
T
CD
L
NNEA
D
PQA
AL
QEIINR
---
PG
P
AL
IHV
R
ID
AE
--------
E
KVY
P
M
V
PP
GA
A
N
T
EM
fig|444447.5.peg.2076
Escherichia coli O157:H7 str. EC4206 (19-559/562)
IV
HF
L
EQQ
G
I
KI
V
T
G
IP
G
GS
I
LP
V
Y
D
A
L
SQS
-
T
Q
I
R
HI
LA
RHEQ
G
A
GFI
A
Q
G
M
A
RTD
GK
P
A
V
--
C
MAC
SGPG
A
TN
L
V
T
AI
A
D
A
RL
D
SI
PLI
C
I
T
G
QVPASM
IG
--
T
D
A
FQE
V
D
TY
--------
GISIPIT
K
HNY
LV
RHI
E
E
LP
QV
M
SD
A
FRI
A
Q
S
-
GRPG
P
V
W
I
D
I
P
K
DV
QTAVFEIE
---
AQPAVAEKAVAP-
-
-AFSEE-S
I
RD
A
AAM
I
NA
A
KR
P
V
L
YL
G
G
G
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
TTMT
L
M
A
LG
ML
P
KA
HP
LSL
GM
L
GM
H
G
VRSTNYI
L
Q
E
AD
L
L
IV
L
G
A
RF
DD
R
AIGKTEQ
F
C
P
-
NA
KI
IH
V
DID
R
A
E
L
GKIKQPH
VAI
QA
D
VDDV
L
AQ
L
I
PQ
V
EA----Q
P
R
A
--
-E
W
H
Q
LVADL
Q
REFPCPIP--KAC
D
----------------------------
P
-
LSHYGLINA
V
AA
----
CVDDNAII
T
T
DVG
QH
QM
W
T
A
QA
-
YPLNR
PR
QW
L
T
S
G
--------
GL
G
T
MG
F
GLP
A
AIGA
AL
A
N
P
DRK
V
L
C
FS
GDG
SLM
M
NIQ
E
MA
T
AS
E
NQ
L
D
V
K
I
I
LM
NN
EA
LG
L
V
H
-
QQQS
L
FYKQGVFAATYPGK
-----------
IN
F
MQ
I
A
A
G
F
G
LE
T
CD
L
NNEA
D
PQA
AL
QEIINR
---
PG
P
AL
IHV
R
ID
AE
--------
E
KVY
P
M
V
PP
GA
A
N
T
EM
fig|478004.5.peg.469
Escherichia coli O157:H7 str. EC4401 (19-559/562)
IV
HF
L
EQQ
G
I
KI
V
T
G
IP
G
GS
I
LP
V
Y
D
A
L
SQS
-
T
Q
I
R
HI
LA
RHEQ
G
A
GFI
A
Q
G
M
A
RTD
GK
P
A
V
--
C
MAC
SGPG
A
TN
L
V
T
AI
A
D
A
RL
D
SI
PLI
C
I
T
G
QVPASM
IG
--
T
D
A
FQE
V
D
TY
--------
GISIPIT
K
HNY
LV
RHI
E
E
LP
QV
M
SD
A
FRI
A
Q
S
-
GRPG
P
V
W
I
D
I
P
K
DV
QTAVFEIE
---
AQPAVAEKAVAP-
-
-AFSEE-S
I
RD
A
AAM
I
NA
A
KR
P
V
L
YL
G
G
G
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
TTMT
L
M
A
LG
ML
P
KA
HP
LSL
GM
L
GM
H
G
VRSTNYI
L
Q
E
AD
L
L
IV
L
G
A
RF
DD
R
AIGKTEQ
F
C
P
-
NA
KI
IH
V
DID
R
A
E
L
GKIKQPH
VAI
QA
D
VDDV
L
AQ
L
I
PQ
V
EA----Q
P
R
A
--
-E
W
H
Q
LVADL
Q
REFPCPIP--KAC
D
----------------------------
P
-
LSHYGLINA
V
AA
----
CVDDNAII
T
T
DVG
QH
QM
W
T
A
QA
-
YPLNR
PR
QW
L
T
S
G
--------
GL
G
T
MG
F
GLP
A
AIGA
AL
A
N
P
DRK
V
L
C
FS
GDG
SLM
M
NIQ
E
MA
T
AS
E
NQ
L
D
V
K
I
I
LM
NN
EA
LG
L
V
H
-
QQQS
L
FYKQGVFAATYPGK
-----------
IN
F
MQ
I
A
A
G
F
G
LE
T
CD
L
NNEA
D
PQA
AL
QEIINR
---
PG
P
AL
IHV
R
ID
AE
--------
E
KVY
P
M
V
PP
GA
A
N
T
EM
fig|478005.5.peg.404
Escherichia coli O157:H7 str. EC4486 (19-559/562)
IV
HF
L
EQQ
G
I
KI
V
T
G
IP
G
GS
I
LP
V
Y
D
A
L
SQS
-
T
Q
I
R
HI
LA
RHEQ
G
A
GFI
A
Q
G
M
A
RTD
GK
P
A
V
--
C
MAC
SGPG
A
TN
L
V
T
AI
A
D
A
RL
D
SI
PLI
C
I
T
G
QVPASM
IG
--
T
D
A
FQE
V
D
TY
--------
GISIPIT
K
HNY
LV
RHI
E
E
LP
QV
M
SD
A
FRI
A
Q
S
-
GRPG
P
V
W
I
D
I
P
K
DV
QTAVFEIE
---
AQPAVAEKAVAP-
-
-AFSEE-S
I
RD
A
AAM
I
NA
A
KR
P
V
L
YL
G
G
G
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
TTMT
L
M
A
LG
ML
P
KA
HP
LSL
GM
L
GM
H
G
VRSTNYI
L
Q
E
AD
L
L
IV
L
G
A
RF
DD
R
AIGKTEQ
F
C
P
-
NA
KI
IH
V
DID
R
A
E
L
GKIKQPH
VAI
QA
D
VDDV
L
AQ
L
I
PQ
V
EA----Q
P
R
A
--
-E
W
H
Q
LVADL
Q
REFPCPIP--KAC
D
----------------------------
P
-
LSHYGLINA
V
AA
----
CVDDNAII
T
T
DVG
QH
QM
W
T
A
QA
-
YPLNR
PR
QW
L
T
S
G
--------
GL
G
T
MG
F
GLP
A
AIGA
AL
A
N
P
DRK
V
L
C
FS
GDG
SLM
M
NIQ
E
MA
T
AS
E
NQ
L
D
V
K
I
I
LM
NN
EA
LG
L
V
H
-
QQQS
L
FYKQGVFAATYPGK
-----------
IN
F
MQ
I
A
A
G
F
G
LE
T
CD
L
NNEA
D
PQA
AL
QEIINR
---
PG
P
AL
IHV
R
ID
AE
--------
E
KVY
P
M
V
PP
GA
A
N
T
EM
fig|478006.5.peg.454
Escherichia coli O157:H7 str. EC4501 (19-559/562)
IV
HF
L
EQQ
G
I
KI
V
T
G
IP
G
GS
I
LP
V
Y
D
A
L
SQS
-
T
Q
I
R
HI
LA
RHEQ
G
A
GFI
A
Q
G
M
A
RTD
GK
P
A
V
--
C
MAC
SGPG
A
TN
L
V
T
AI
A
D
A
RL
D
SI
PLI
C
I
T
G
QVPASM
IG
--
T
D
A
FQE
V
D
TY
--------
GISIPIT
K
HNY
LV
RHI
E
E
LP
QV
M
SD
A
FRI
A
Q
S
-
GRPG
P
V
W
I
D
I
P
K
DV
QTAVFEIE
---
AQPAVAEKAVAP-
-
-AFSEE-S
I
RD
A
AAM
I
NA
A
KR
P
V
L
YL
G
G
G
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
TTMT
L
M
A
LG
ML
P
KA
HP
LSL
GM
L
GM
H
G
VRSTNYI
L
Q
E
AD
L
L
IV
L
G
A
RF
DD
R
AIGKTEQ
F
C
P
-
NA
KI
IH
V
DID
R
A
E
L
GKIKQPH
VAI
QA
D
VDDV
L
AQ
L
I
PQ
V
EA----Q
P
R
A
--
-E
W
H
Q
LVADL
Q
REFPCPIP--KAC
D
----------------------------
P
-
LSHYGLINA
V
AA
----
CVDDNAII
T
T
DVG
QH
QM
W
T
A
QA
-
YPLNR
PR
QW
L
T
S
G
--------
GL
G
T
MG
F
GLP
A
AIGA
AL
A
N
P
DRK
V
L
C
FS
GDG
SLM
M
NIQ
E
MA
T
AS
E
NQ
L
D
V
K
I
I
LM
NN
EA
LG
L
V
H
-
QQQS
L
FYKQGVFAATYPGK
-----------
IN
F
MQ
I
A
A
G
F
G
LE
T
CD
L
NNEA
D
PQA
AL
QEIINR
---
PG
P
AL
IHV
R
ID
AE
--------
E
KVY
P
M
V
PP
GA
A
N
T
EM
fig|478007.5.peg.1513
Escherichia coli O157:H7 str. EC508 (19-559/562)
IV
HF
L
EQQ
G
I
KI
V
T
G
IP
G
GS
I
LP
V
Y
D
A
L
SQS
-
T
Q
I
R
HI
LA
RHEQ
G
A
GFI
A
Q
G
M
A
RTD
GK
P
A
V
--
C
MAC
SGPG
A
TN
L
V
T
AI
A
D
A
RL
D
SI
PLI
C
I
T
G
QVPASM
IG
--
T
D
A
FQE
V
D
TY
--------
GISIPIT
K
HNY
LV
RHI
E
E
LP
QV
M
SD
A
FRI
A
Q
S
-
GRPG
P
V
W
I
D
I
P
K
DV
QTAVFEIE
---
AQPAVAEKAVAP-
-
-AFSEE-S
I
RD
A
AAM
I
NA
A
KR
P
V
L
YL
G
G
G
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
TTMT
L
M
A
LG
ML
P
KA
HP
LSL
GM
L
GM
H
G
VRSTNYI
L
Q
E
AD
L
L
IV
L
G
A
RF
DD
R
AIGKTEQ
F
C
P
-
NA
KI
IH
V
DID
R
A
E
L
GKIKQPH
VAI
QA
D
VDDV
L
AQ
L
I
PQ
V
EA----Q
P
R
A
--
-E
W
H
Q
LVADL
Q
REFPCPIP--KAC
D
----------------------------
P
-
LSHYGLINA
V
AA
----
CVDDNAII
T
T
DVG
QH
QM
W
T
A
QA
-
YPLNR
PR
QW
L
T
S
G
--------
GL
G
T
MG
F
GLP
A
AIGA
AL
A
N
P
DRK
V
L
C
FS
GDG
SLM
M
NIQ
E
MA
T
AS
E
NQ
L
D
V
K
I
I
LM
NN
EA
LG
L
V
H
-
QQQS
L
FYKQGVFAATYPGK
-----------
IN
F
MQ
I
A
A
G
F
G
LE
T
CD
L
NNEA
D
PQA
AL
QEIINR
---
PG
P
AL
IHV
R
ID
AE
--------
E
KVY
P
M
V
PP
GA
A
N
T
EM
fig|478008.5.peg.976
Escherichia coli O157:H7 str. EC869 (19-559/562)
IV
HF
L
EQQ
G
I
KI
V
T
G
IP
G
GS
I
LP
V
Y
D
A
L
SQS
-
T
Q
I
R
HI
LA
RHEQ
G
A
GFI
A
Q
G
M
A
RTD
GK
P
A
V
--
C
MAC
SGPG
A
TN
L
V
T
AI
A
D
A
RL
D
SI
PLI
C
I
T
G
QVPASM
IG
--
T
D
A
FQE
V
D
TY
--------
GISIPIT
K
HNY
LV
RHI
E
E
LP
QV
M
SD
A
FRI
A
Q
S
-
GRPG
P
V
W
I
D
I
P
K
DV
QTAVFEIE
---
AQPAVAEKAVAP-
-
-AFSEE-S
I
RD
A
AAM
I
NA
A
KR
P
V
L
YL
G
G
G
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
TTMT
L
M
A
LG
ML
P
KA
HP
LSL
GM
L
GM
H
G
VRSTNYI
L
Q
E
AD
L
L
IV
L
G
A
RF
DD
R
AIGKTEQ
F
C
P
-
NA
KI
IH
V
DID
R
A
E
L
GKIKQPH
VAI
QA
D
VDDV
L
AQ
L
I
PQ
V
EA----Q
P
R
A
--
-E
W
H
Q
LVADL
Q
REFPCPIP--KAC
D
----------------------------
P
-
LSHYGLINA
V
AA
----
CVDDNAII
T
T
DVG
QH
QM
W
T
A
QA
-
YPLNR
PR
QW
L
T
S
G
--------
GL
G
T
MG
F
GLP
A
AIGA
AL
A
N
P
DRK
V
L
C
FS
GDG
SLM
M
NIQ
E
MA
T
AS
E
NQ
L
D
V
K
I
I
LM
NN
EA
LG
L
V
H
-
QQQS
L
FYKQGVFAATYPGK
-----------
IN
F
MQ
I
A
A
G
F
G
LE
T
CD
L
NNEA
D
PQA
AL
QEIINR
---
PG
P
AL
IHV
R
ID
AE
--------
E
KVY
P
M
V
PP
GA
A
N
T
EM
fig|637388.3.peg.2932
Escherichia coli O157:H7 str. FRIK2000 (19-559/562)
IV
HF
L
EQQ
G
I
KI
V
T
G
IP
G
GS
I
LP
V
Y
D
A
L
SQS
-
T
Q
I
R
HI
LA
RHEQ
G
A
GFI
A
Q
G
M
A
RTD
GK
P
A
V
--
C
MAC
SGPG
A
TN
L
V
T
AI
A
D
A
RL
D
SI
PLI
C
I
T
G
QVPASM
IG
--
T
D
A
FQE
V
D
TY
--------
GISIPIT
K
HNY
LV
RHI
E
E
LP
QV
M
SD
A
FRI
A
Q
S
-
GRPG
P
V
W
I
D
I
P
K
DV
QTAVFEIE
---
AQPAVAEKAVAP-
-
-AFSEE-S
I
RD
A
AAM
I
NA
A
KR
P
V
L
YL
G
G
G
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
TTMT
L
M
A
LG
ML
P
KA
HP
LSL
GM
L
GM
H
G
VRSTNYI
L
Q
E
AD
L
L
IV
L
G
A
RF
DD
R
AIGKTEQ
F
C
P
-
NA
KI
IH
V
DID
R
A
E
L
GKIKQPH
VAI
QA
D
VDDV
L
AQ
L
I
PQ
V
EA----Q
P
R
A
--
-E
W
H
Q
LVADL
Q
REFPCPIP--KAC
D
----------------------------
P
-
LSHYGLINA
V
AA
----
CVDDNAII
T
T
DVG
QH
QM
W
T
A
QA
-
YPLNR
PR
QW
L
T
S
G
--------
GL
G
T
MG
F
GLP
A
AIGA
AL
A
N
P
DRK
V
L
C
FS
GDG
SLM
M
NIQ
E
MA
T
AS
E
NQ
L
D
V
K
I
I
LM
NN
EA
LG
L
V
H
-
QQQS
L
FYKQGVFAATYPGK
-----------
IN
F
MQ
I
A
A
G
F
G
LE
T
CD
L
NNEA
D
PQA
AL
QEIINR
---
PG
P
AL
IHV
R
ID
AE
--------
E
KVY
P
M
V
PP
GA
A
N
T
EM
fig|570506.3.peg.4725
Escherichia coli O157:H7 str. FRIK966 (19-559/562)
IV
HF
L
EQQ
G
I
KI
V
T
G
IP
G
GS
I
LP
V
Y
D
A
L
SQS
-
T
Q
I
R
HI
LA
RHEQ
G
A
GFI
A
Q
G
M
A
RTD
GK
P
A
V
--
C
MAC
SGPG
A
TN
L
V
T
AI
A
D
A
RL
D
SI
PLI
C
I
T
G
QVPASM
IG
--
T
D
A
FQE
V
D
TY
--------
GISIPIT
K
HNY
LV
RHI
E
E
LP
QV
M
SD
A
FRI
A
Q
S
-
GRPG
P
V
W
I
D
I
P
K
DV
QTAVFEIE
---
AQPAVAEKAVAP-
-
-AFSEE-S
I
RD
A
AAM
I
NA
A
KR
P
V
L
YL
G
G
G
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
TTMT
L
M
A
LG
ML
P
KA
HP
LSL
GM
L
GM
H
G
VRSTNYI
L
Q
E
AD
L
L
IV
L
G
A
RF
DD
R
AIGKTEQ
F
C
P
-
NA
KI
IH
V
DID
R
A
E
L
GKIKQPH
VAI
QA
D
VDDV
L
AQ
L
I
PQ
V
EA----Q
P
R
A
--
-E
W
H
Q
LVADL
Q
REFPCPIP--KAC
D
----------------------------
P
-
LSHYGLINA
V
AA
----
CVDDNAII
T
T
DVG
QH
QM
W
T
A
QA
-
YPLNR
PR
QW
L
T
S
G
--------
GL
G
T
MG
F
GLP
A
AIGA
AL
A
N
P
DRK
V
L
C
FS
GDG
SLM
M
NIQ
E
MA
T
AS
E
NQ
L
D
V
K
I
I
LM
NN
EA
LG
L
V
H
-
QQQS
L
FYKQGVFAATYPGK
-----------
IN
F
MQ
I
A
A
G
F
G
LE
T
CD
L
NNEA
D
PQA
AL
QEIINR
---
PG
P
AL
IHV
R
ID
AE
--------
E
KVY
P
M
V
PP
GA
A
N
T
EM
fig|386585.9.peg.4819
Escherichia coli O157:H7 str. Sakai (19-559/562)
IV
HF
L
EQQ
G
I
KI
V
T
G
IP
G
GS
I
LP
V
Y
D
A
L
SQS
-
T
Q
I
R
HI
LA
RHEQ
G
A
GFI
A
Q
G
M
A
RTD
GK
P
A
V
--
C
MAC
SGPG
A
TN
L
V
T
AI
A
D
A
RL
D
SI
PLI
C
I
T
G
QVPASM
IG
--
T
D
A
FQE
V
D
TY
--------
GISIPIT
K
HNY
LV
RHI
E
E
LP
QV
M
SD
A
FRI
A
Q
S
-
GRPG
P
V
W
I
D
I
P
K
DV
QTAVFEIE
---
AQPAVAEKAVAP-
-
-AFSEE-S
I
RD
A
AAM
I
NA
A
KR
P
V
L
YL
G
G
G
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
TTMT
L
M
A
LG
ML
P
KA
HP
LSL
GM
L
GM
H
G
VRSTNYI
L
Q
E
AD
L
L
IV
L
G
A
RF
DD
R
AIGKTEQ
F
C
P
-
NA
KI
IH
V
DID
R
A
E
L
GKIKQPH
VAI
QA
D
VDDV
L
AQ
L
I
PQ
V
EA----Q
P
R
A
--
-E
W
H
Q
LVADL
Q
REFPCPIP--KAC
D
----------------------------
P
-
LSHYGLINA
V
AA
----
CVDDNAII
T
T
DVG
QH
QM
W
T
A
QA
-
YPLNR
PR
QW
L
T
S
G
--------
GL
G
T
MG
F
GLP
A
AIGA
AL
A
N
P
DRK
V
L
C
FS
GDG
SLM
M
NIQ
E
MA
T
AS
E
NQ
L
D
V
K
I
I
LM
NN
EA
LG
L
V
H
-
QQQS
L
FYKQGVFAATYPGK
-----------
IN
F
MQ
I
A
A
G
F
G
LE
T
CD
L
NNEA
D
PQA
AL
QEIINR
---
PG
P
AL
IHV
R
ID
AE
--------
E
KVY
P
M
V
PP
GA
A
N
T
EM
fig|544404.4.peg.4805
Escherichia coli O157:H7 str. TW14359 (19-559/562)
IV
HF
L
EQQ
G
I
KI
V
T
G
IP
G
GS
I
LP
V
Y
D
A
L
SQS
-
T
Q
I
R
HI
LA
RHEQ
G
A
GFI
A
Q
G
M
A
RTD
GK
P
A
V
--
C
MAC
SGPG
A
TN
L
V
T
AI
A
D
A
RL
D
SI
PLI
C
I
T
G
QVPASM
IG
--
T
D
A
FQE
V
D
TY
--------
GISIPIT
K
HNY
LV
RHI
E
E
LP
QV
M
SD
A
FRI
A
Q
S
-
GRPG
P
V
W
I
D
I
P
K
DV
QTAVFEIE
---
AQPAVAEKAVAP-
-
-AFSEE-S
I
RD
A
AAM
I
NA
A
KR
P
V
L
YL
G
G
G
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
TTMT
L
M
A
LG
ML
P
KA
HP
LSL
GM
L
GM
H
G
VRSTNYI
L
Q
E
AD
L
L
IV
L
G
A
RF
DD
R
AIGKTEQ
F
C
P
-
NA
KI
IH
V
DID
R
A
E
L
GKIKQPH
VAI
QA
D
VDDV
L
AQ
L
I
PQ
V
EA----Q
P
R
A
--
-E
W
H
Q
LVADL
Q
REFPCPIP--KAC
D
----------------------------
P
-
LSHYGLINA
V
AA
----
CVDDNAII
T
T
DVG
QH
QM
W
T
A
QA
-
YPLNR
PR
QW
L
T
S
G
--------
GL
G
T
MG
F
GLP
A
AIGA
AL
A
N
P
DRK
V
L
C
FS
GDG
SLM
M
NIQ
E
MA
T
AS
E
NQ
L
D
V
K
I
I
LM
NN
EA
LG
L
V
H
-
QQQS
L
FYKQGVFAATYPGK
-----------
IN
F
MQ
I
A
A
G
F
G
LE
T
CD
L
NNEA
D
PQA
AL
QEIINR
---
PG
P
AL
IHV
R
ID
AE
--------
E
KVY
P
M
V
PP
GA
A
N
T
EM
fig|502346.5.peg.2002
Escherichia coli O157:H7 str. TW14588 (19-559/562)
IV
HF
L
EQQ
G
I
KI
V
T
G
IP
G
GS
I
LP
V
Y
D
A
L
SQS
-
T
Q
I
R
HI
LA
RHEQ
G
A
GFI
A
Q
G
M
A
RTD
GK
P
A
V
--
C
MAC
SGPG
A
TN
L
V
T
AI
A
D
A
RL
D
SI
PLI
C
I
T
G
QVPASM
IG
--
T
D
A
FQE
V
D
TY
--------
GISIPIT
K
HNY
LV
RHI
E
E
LP
QV
M
SD
A
FRI
A
Q
S
-
GRPG
P
V
W
I
D
I
P
K
DV
QTAVFEIE
---
AQPAVAEKAVAP-
-
-AFSEE-S
I
RD
A
AAM
I
NA
A
KR
P
V
L
YL
G
G
G
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
TTMT
L
M
A
LG
ML
P
KA
HP
LSL
GM
L
GM
H
G
VRSTNYI
L
Q
E
AD
L
L
IV
L
G
A
RF
DD
R
AIGKTEQ
F
C
P
-
NA
KI
IH
V
DID
R
A
E
L
GKIKQPH
VAI
QA
D
VDDV
L
AQ
L
I
PQ
V
EA----Q
P
R
A
--
-E
W
H
Q
LVADL
Q
REFPCPIP--KAC
D
----------------------------
P
-
LSHYGLINA
V
AA
----
CVDDNAII
T
T
DVG
QH
QM
W
T
A
QA
-
YPLNR
PR
QW
L
T
S
G
--------
GL
G
T
MG
F
GLP
A
AIGA
AL
A
N
P
DRK
V
L
C
FS
GDG
SLM
M
NIQ
E
MA
T
AS
E
NQ
L
D
V
K
I
I
LM
NN
EA
LG
L
V
H
-
QQQS
L
FYKQGVFAATYPGK
-----------
IN
F
MQ
I
A
A
G
F
G
LE
T
CD
L
NNEA
D
PQA
AL
QEIINR
---
PG
P
AL
IHV
R
ID
AE
--------
E
KVY
P
M
V
PP
GA
A
N
T
EM
fig|701177.3.peg.4488
Escherichia coli O55:H7 str. CB9615 (19-559/562)
IV
HF
L
EQQ
G
I
KI
V
T
G
IP
G
GS
I
LP
V
Y
D
A
L
SQS
-
T
Q
I
R
HI
LA
RHEQ
G
A
GFI
A
Q
G
M
A
RTD
GK
P
A
V
--
C
MAC
SGPG
A
TN
L
V
T
AI
A
D
A
RL
D
SI
PLI
C
I
T
G
QVPASM
IG
--
T
D
A
FQE
V
D
TY
--------
GISIPIT
K
HNY
LV
RHI
E
E
LP
QV
M
SD
A
FRI
A
Q
S
-
GRPG
P
V
W
I
D
I
P
K
DV
QTAVFEIE
---
AQPAVAEKAVAP-
-
-AFSEE-S
I
RD
A
AAM
I
NA
A
KR
P
V
L
YL
G
G
G
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
TTMT
L
M
A
LG
ML
P
KA
HP
LSL
GM
L
GM
H
G
VRSTNYI
L
Q
E
AD
L
L
IV
L
G
A
RF
DD
R
AIGKTEQ
F
C
P
-
NA
KI
IH
V
DID
R
A
E
L
GKIKQPH
VAI
QA
D
VDDV
L
AQ
L
I
PQ
V
EA----Q
P
R
A
--
-E
W
H
Q
LVADL
Q
REFPCPIP--KAC
D
----------------------------
P
-
LSHYGLINA
V
AA
----
CVDDNAII
T
T
DVG
QH
QM
W
T
A
QA
-
YPLNR
PR
QW
L
T
S
G
--------
GL
G
T
MG
F
GLP
A
AIGA
AL
A
N
P
DRK
V
L
C
FS
GDG
SLM
M
NIQ
E
MA
T
AS
E
NQ
L
D
V
K
I
I
LM
NN
EA
LG
L
V
H
-
QQQS
L
FYKQGVFAATYPGK
-----------
IN
F
MQ
I
A
A
G
F
G
LE
T
CD
L
NNEA
D
PQA
AL
QEIINR
---
PG
P
AL
IHV
R
ID
AE
--------
E
KVY
P
M
V
PP
GA
A
N
T
EM
fig|656444.3.peg.5010
Escherichia coli TA280 (19-559/562)
IV
HF
L
EQQ
G
I
KI
V
T
G
IP
G
GS
I
LP
V
Y
D
A
L
SQS
-
T
Q
I
R
HI
LA
RHEQ
G
A
GFI
A
Q
G
M
A
RTD
GK
P
A
V
--
C
MAC
SGPG
A
TN
L
V
T
AI
A
D
A
RL
D
SI
PLI
C
I
T
G
QVPASM
IG
--
T
D
A
FQE
V
D
TY
--------
GISIPIT
K
HNY
LV
RHI
E
E
LP
QV
M
SD
A
FRI
A
Q
S
-
GRPG
P
V
W
I
D
I
P
K
DV
QTAVFEIE
---
AQPAVAEKAVAP-
-
-AFSEE-S
I
RD
A
AAM
I
NA
A
KR
P
V
L
YL
G
G
G
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
TTMT
L
M
A
LG
ML
P
KA
HP
LSL
GM
L
GM
H
G
VRSTNYI
L
Q
E
AD
L
L
IV
L
G
A
RF
DD
R
AIGKTEQ
F
C
P
-
NA
KI
IH
V
DID
R
A
E
L
GKIKQPH
VAI
QA
D
VDDV
L
AQ
L
I
PQ
V
EA----Q
P
R
A
--
-E
W
H
Q
LVADL
Q
REFPCPIP--KAC
D
----------------------------
P
-
LSHYGLINA
V
AA
----
CVDDNAII
T
T
DVG
QH
QM
W
T
A
QA
-
YPLNR
PR
QW
L
T
S
G
--------
GL
G
T
MG
F
GLP
A
AIGA
AL
A
N
P
DRK
V
L
C
FS
GDG
SLM
M
NIQ
E
MA
T
AS
E
NQ
L
D
V
K
I
I
LM
NN
EA
LG
L
V
H
-
QQQS
L
FYKQGVFAATYPGK
-----------
IN
F
MQ
I
A
A
G
F
G
LE
T
CD
L
NNEA
D
PQA
AL
QEIINR
---
PG
P
AL
IHV
R
ID
AE
--------
E
KVY
P
M
V
PP
GA
A
N
T
EM
fig|656379.3.peg.4529
Escherichia coli FVEC1302 (19-559/562)
IV
HF
L
EQQ
G
I
KI
V
T
G
IP
G
GS
I
LP
V
Y
D
A
L
SQS
-
T
Q
I
R
HI
LA
RHEQ
G
A
GFI
A
Q
G
M
A
RTD
GK
P
A
V
--
C
MAC
SGPG
A
TN
L
V
T
AI
A
D
A
RL
D
SI
PLI
C
I
T
G
QVPASM
IG
--
T
D
A
FQE
V
D
TY
--------
GISIPIT
K
HNY
LV
RHI
E
E
LP
QV
M
SD
A
FRI
A
Q
S
-
GRPG
P
V
W
I
D
I
P
K
DV
QTAVFEIE
---
AQPAVAEKAVAP-
-
-AFSEE-S
I
RD
A
AAM
I
NA
A
KR
P
V
L
YL
G
G
G
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
TTMT
L
M
A
LG
ML
P
KA
HP
LSL
GM
L
GM
H
G
VRSTNYI
L
Q
E
AD
L
L
IV
L
G
A
RF
DD
R
AIGKTEQ
F
C
P
-
NA
KI
IH
V
DID
R
A
E
L
GKIKQPH
VAI
QA
D
VDDV
L
AQ
L
I
PL
V
EA----Q
P
R
A
--
-E
W
H
Q
LVADL
Q
REFPCPIP--KAC
D
----------------------------
P
-
LSHYGLINA
V
AA
----
CVDDSAII
T
T
DVG
QH
QM
W
T
A
QA
-
YPLNR
PR
QW
L
T
S
G
--------
GL
G
T
MG
F
GLP
T
AIGA
AL
A
N
P
DRK
V
L
C
FS
GDG
SLM
M
NIQ
E
MA
T
AS
E
NQ
L
D
V
K
I
I
LM
NN
EA
LG
L
V
H
-
QQQS
L
FYKQGVFAATYPGK
-----------
IN
F
MQ
I
A
A
G
F
G
LE
T
CD
L
NNEA
D
PQA
AL
QEIINR
---
PG
P
AL
IHV
R
ID
AE
--------
E
KVY
P
M
V
PP
GA
A
N
T
EM
fig|656380.3.peg.4813
Escherichia coli FVEC1412 (19-559/562)
IV
HF
L
EQQ
G
I
KI
V
T
G
IP
G
GS
I
LP
V
Y
D
A
L
SQS
-
T
Q
I
R
HI
LA
RHEQ
G
A
GFI
A
Q
G
M
A
RTD
GK
P
A
V
--
C
MAC
SGPG
A
TN
L
V
T
AI
A
D
A
RL
D
SI
PLI
C
I
T
G
QVPASM
IG
--
T
D
A
FQE
V
D
TY
--------
GISIPIT
K
HNY
LV
RHI
E
E
LP
QV
M
SD
A
FRI
A
Q
S
-
GRPG
P
V
W
I
D
I
P
K
DV
QTAVFEIE
---
AQPAVAEKAVAP-
-
-AFSEE-S
I
RD
A
AAM
I
NA
A
KR
P
V
L
YL
G
G
G
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
TTMT
L
M
A
LG
ML
P
KA
HP
LSL
GM
L
GM
H
G
VRSTNYI
L
Q
E
AD
L
L
IV
L
G
A
RF
DD
R
AIGKTEQ
F
C
P
-
NA
KI
IH
V
DID
R
A
E
L
GKIKQPH
VAI
QA
D
VDDV
L
AQ
L
I
PL
V
EA----Q
P
R
A
--
-E
W
H
Q
LVADL
Q
REFPCPIP--KAC
D
----------------------------
P
-
LSHYGLINA
V
AA
----
CVDDSAII
T
T
DVG
QH
QM
W
T
A
QA
-
YPLNR
PR
QW
L
T
S
G
--------
GL
G
T
MG
F
GLP
T
AIGA
AL
A
N
P
DRK
V
L
C
FS
GDG
SLM
M
NIQ
E
MA
T
AS
E
NQ
L
D
V
K
I
I
LM
NN
EA
LG
L
V
H
-
QQQS
L
FYKQGVFAATYPGK
-----------
IN
F
MQ
I
A
A
G
F
G
LE
T
CD
L
NNEA
D
PQA
AL
QEIINR
---
PG
P
AL
IHV
R
ID
AE
--------
E
KVY
P
M
V
PP
GA
A
N
T
EM
fig|749549.3.peg.1355
Escherichia coli MS 198-1 (19-559/562)
IV
HF
L
EQQ
G
I
KI
V
T
G
IP
G
GS
I
LP
V
Y
D
A
L
SQS
-
T
Q
I
R
HI
LA
RHEQ
G
A
GFI
A
Q
G
M
A
RTD
GK
P
A
V
--
C
MAC
SGPG
A
TN
L
V
T
AI
A
D
A
RL
D
SI
PLI
C
I
T
G
QVPASM
IG
--
T
D
A
FQE
V
D
TY
--------
GISIPIT
K
HNY
LV
RHI
E
E
LP
QV
M
SD
A
FRI
A
Q
S
-
GRPG
P
V
W
I
D
I
P
K
DV
QTAVFEIE
---
AQPAVAEKAVAP-
-
-AFSEE-S
I
RD
A
AAM
I
NA
A
KR
P
V
L
YL
G
G
G
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
TTMT
L
M
A
LG
ML
P
KA
HP
LSL
GM
L
GM
H
G
VRSTNYI
L
Q
E
AD
L
L
IV
L
G
A
RF
DD
R
AIGKTEQ
F
C
P
-
NA
KI
IH
V
DID
R
A
E
L
GKIKQPH
VAI
QA
D
VDDV
L
AQ
L
I
PL
V
EA----Q
P
R
A
--
-E
W
H
Q
LVADL
Q
REFPCPIP--KAC
D
----------------------------
P
-
LSHYGLINA
V
AA
----
CVDDSAII
T
T
DVG
QH
QM
W
T
A
QA
-
YPLNR
PR
QW
L
T
S
G
--------
GL
G
T
MG
F
GLP
T
AIGA
AL
A
N
P
DRK
V
L
C
FS
GDG
SLM
M
NIQ
E
MA
T
AS
E
NQ
L
D
V
K
I
I
LM
NN
EA
LG
L
V
H
-
QQQS
L
FYKQGVFAATYPGK
-----------
IN
F
MQ
I
A
A
G
F
G
LE
T
CD
L
NNEA
D
PQA
AL
QEIINR
---
PG
P
AL
IHV
R
ID
AE
--------
E
KVY
P
M
V
PP
GA
A
N
T
EM
fig|585056.7.peg.4374
Escherichia coli UMN026 (19-559/562)
IV
HF
L
EQQ
G
I
KI
V
T
G
IP
G
GS
I
LP
V
Y
D
A
L
SQS
-
T
Q
I
R
HI
LA
RHEQ
G
A
GFI
A
Q
G
M
A
RTD
GK
P
A
V
--
C
MAC
SGPG
A
TN
L
V
T
AI
A
D
A
RL
D
SI
PLI
C
I
T
G
QVPASM
IG
--
T
D
A
FQE
V
D
TY
--------
GISIPIT
K
HNY
LV
RHI
E
E
LP
QV
M
SD
A
FRI
A
Q
S
-
GRPG
P
V
W
I
D
I
P
K
DV
QTAVFEIE
---
AQPAVAEKAVAP-
-
-AFSEE-S
I
RD
A
AAM
I
NA
A
KR
P
V
L
YL
G
G
G
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
TTMT
L
M
A
LG
ML
P
KA
HP
LSL
GM
L
GM
H
G
VRSTNYI
L
Q
E
AD
L
L
IV
L
G
A
RF
DD
R
AIGKTEQ
F
C
P
-
NA
KI
IH
V
DID
R
A
E
L
GKIKQPH
VAI
QA
D
VDDV
L
AQ
L
I
PL
V
EA----Q
P
R
A
--
-E
W
H
Q
LVADL
Q
REFPCPIP--KAC
D
----------------------------
P
-
LSHYGLINA
V
AA
----
CVDDSAII
T
T
DVG
QH
QM
W
T
A
QA
-
YPLNR
PR
QW
L
T
S
G
--------
GL
G
T
MG
F
GLP
T
AIGA
AL
A
N
P
DRK
V
L
C
FS
GDG
SLM
M
NIQ
E
MA
T
AS
E
NQ
L
D
V
K
I
I
LM
NN
EA
LG
L
V
H
-
QQQS
L
FYKQGVFAATYPGK
-----------
IN
F
MQ
I
A
A
G
F
G
LE
T
CD
L
NNEA
D
PQA
AL
QEIINR
---
PG
P
AL
IHV
R
ID
AE
--------
E
KVY
P
M
V
PP
GA
A
N
T
EM
fig|155864.1.peg.4618
Escherichia coli O157:H7 EDL933 (19-559/562)
IV
HF
L
EQQ
G
I
KI
V
T
G
IP
G
GS
I
LP
V
Y
D
A
L
SQS
-
T
Q
I
R
HI
LA
RHEQ
G
A
GFI
A
Q
G
M
A
RTD
GK
P
A
V
--
C
MAC
SGPG
A
TN
L
V
T
AI
A
D
A
RL
D
SI
PLI
C
I
T
G
QVPASM
IG
--
T
D
A
FQE
V
D
TY
--------
GISIPIT
K
HNY
LV
RHI
E
E
LP
QV
M
SD
A
FRI
A
Q
S
-
GRPG
P
V
W
I
D
I
P
K
DV
QTAVFEIE
---
AQPAVAEKAVAP-
-
-AFSEE-S
I
RD
A
AAM
I
NA
A
KR
P
V
L
YL
G
G
G
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
TTMT
L
M
A
LG
ML
P
KA
HP
LSL
GM
L
GM
H
G
VRSTNYI
L
Q
E
AD
L
L
IV
L
G
A
RF
DD
R
AIGKTEQ
F
C
P
-
NA
KI
IH
V
DID
R
A
E
L
GKIKQPH
VAI
QA
D
VDDV
L
AQ
L
I
PQ
V
EA----Q
P
R
A
--
-E
W
H
Q
LVADX
Q
REFPCPIP--KAC
D
----------------------------
P
-
LSHYGLINA
V
AA
----
CVDDNAII
T
T
DVG
QH
QM
W
T
A
QA
-
YPLNR
PR
QW
L
T
S
G
--------
GL
G
T
MG
F
GLP
A
AIGA
AL
A
N
P
DRK
V
L
C
FS
GDG
SLM
M
NIQ
E
MA
T
AS
E
NQ
L
D
V
K
I
I
LM
NN
EA
LG
L
V
H
-
QQQS
L
FYKQGVFAATYPGK
-----------
IN
F
MQ
I
A
A
G
F
G
LE
T
CD
L
NNEA
D
PQA
AL
QEIINR
---
PG
P
AL
IHV
R
ID
AE
--------
E
KVY
P
M
V
PP
GA
A
N
T
EM
fig|155864.8.peg.4577
Escherichia coli O157:H7 EDL933 (19-559/562)
IV
HF
L
EQQ
G
I
KI
V
T
G
IP
G
GS
I
LP
V
Y
D
A
L
SQS
-
T
Q
I
R
HI
LA
RHEQ
G
A
GFI
A
Q
G
M
A
RTD
GK
P
A
V
--
C
MAC
SGPG
A
TN
L
V
T
AI
A
D
A
RL
D
SI
PLI
C
I
T
G
QVPASM
IG
--
T
D
A
FQE
V
D
TY
--------
GISIPIT
K
HNY
LV
RHI
E
E
LP
QV
M
SD
A
FRI
A
Q
S
-
GRPG
P
V
W
I
D
I
P
K
DV
QTAVFEIE
---
AQPAVAEKAVAP-
-
-AFSEE-S
I
RD
A
AAM
I
NA
A
KR
P
V
L
YL
G
G
G
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
TTMT
L
M
A
LG
ML
P
KA
HP
LSL
GM
L
GM
H
G
VRSTNYI
L
Q
E
AD
L
L
IV
L
G
A
RF
DD
R
AIGKTEQ
F
C
P
-
NA
KI
IH
V
DID
R
A
E
L
GKIKQPH
VAI
QA
D
VDDV
L
AQ
L
I
PQ
V
EA----Q
P
R
A
--
-E
W
H
Q
LVADX
Q
REFPCPIP--KAC
D
----------------------------
P
-
LSHYGLINA
V
AA
----
CVDDNAII
T
T
DVG
QH
QM
W
T
A
QA
-
YPLNR
PR
QW
L
T
S
G
--------
GL
G
T
MG
F
GLP
A
AIGA
AL
A
N
P
DRK
V
L
C
FS
GDG
SLM
M
NIQ
E
MA
T
AS
E
NQ
L
D
V
K
I
I
LM
NN
EA
LG
L
V
H
-
QQQS
L
FYKQGVFAATYPGK
-----------
IN
F
MQ
I
A
A
G
F
G
LE
T
CD
L
NNEA
D
PQA
AL
QEIINR
---
PG
P
AL
IHV
R
ID
AE
--------
E
KVY
P
M
V
PP
GA
A
N
T
EM
fig|656437.3.peg.4151
Escherichia coli TA143 (19-559/562)
IV
HF
L
EQQ
G
I
KI
V
T
G
IP
G
GS
I
LP
V
Y
D
A
L
SQS
-
T
Q
I
R
HI
LA
RHEQ
G
A
GFI
A
Q
G
M
A
RTD
GK
P
A
V
--
C
MAC
SGPG
A
TN
L
V
T
AI
A
D
A
RL
D
SI
PLI
C
I
T
G
QVPASM
IG
--
T
D
A
FQE
V
D
TY
--------
GISIPIT
K
HNY
LV
RHI
E
E
LP
QV
M
SD
A
FRI
A
Q
S
-
GRPG
P
V
W
I
D
I
P
K
DV
QTAVFEIE
---
AQPAVAEKAVAP-
-
-AFSEE-S
I
RD
A
AAM
I
NA
A
KR
P
V
L
YL
G
G
G
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
TTMT
L
M
A
LG
ML
P
KA
HP
LSL
GM
L
GM
H
G
VRSTNYI
L
Q
E
AD
L
L
IV
L
G
A
RF
DD
R
AIGKTEQ
F
C
P
-
NA
KI
IH
V
DID
R
A
E
L
GKIKQPH
VAI
QA
D
VDDV
L
AQ
L
I
PQ
V
EA----Q
P
R
A
--
-E
W
H
Q
LVADL
Q
REFPCPIP--KAC
D
----------------------------
P
-
LSHYGLINA
V
AA
----
CVDDNAII
T
T
DVG
QH
QM
W
T
A
QA
-
YPLNR
PR
QW
L
T
S
G
--------
GL
G
T
MG
F
GLP
A
AIGA
AL
A
N
P
DRK
V
L
C
FS
GDG
SLM
M
NIQ
E
MA
T
AS
E
NQ
L
D
V
K
I
I
LM
NN
EA
LG
L
V
H
-
QQQS
L
FYKQGVFAATYPGK
-----------
IN
F
MQ
I
A
A
G
F
G
LE
T
CD
L
NDEA
D
PQA
AL
QEIINR
---
PG
P
AL
IHV
R
ID
AE
--------
E
KVY
P
M
V
PP
GA
A
N
T
EM
fig|550677.3.peg.4260
Escherichia coli B354 (19-559/562)
IV
HF
L
EQQ
G
I
KI
V
T
G
IP
G
GS
I
LP
V
Y
D
A
L
SQS
-
T
Q
I
R
HI
LA
RHEQ
G
A
GFI
A
Q
G
M
A
RTD
GK
P
A
V
--
C
MAC
SGPG
A
TN
L
V
T
AI
A
D
A
RL
D
SI
PLI
C
I
T
G
QVPASM
IG
--
T
D
A
FQE
V
D
TY
--------
GISIPIT
K
HNY
LV
RHI
E
E
LP
QV
M
SD
A
FRI
A
Q
S
-
GRPG
P
V
W
I
D
I
P
K
DV
QTAVFEIE
---
AQPAVAEKAVAP-
-
-AFSEE-S
I
HD
A
AAM
I
NA
A
KR
P
V
L
YL
G
G
G
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
TTMT
L
M
A
LG
ML
P
KA
HP
LSL
GM
L
GM
H
G
VRSTNYI
L
Q
E
AD
L
L
IV
L
G
A
RF
DD
R
AIGKTEQ
F
C
P
-
NA
KI
IH
V
DID
R
A
E
L
GKIKQPH
VAI
QA
D
VDDV
L
AQ
L
I
PQ
V
EA----Q
P
R
A
--
-E
W
H
Q
LVADL
Q
REFPCPIP--KAC
D
----------------------------
P
-
LSHYGLINA
V
AA
----
CVDDNAII
T
T
DVG
QH
QM
W
T
A
QA
-
YPLNR
PR
QW
L
T
S
G
--------
GL
G
T
MG
F
GLP
A
AIGA
AL
A
N
P
DRK
V
L
C
FS
GDG
SLM
M
NIQ
E
MA
T
AS
E
NQ
L
D
V
K
I
I
LM
NN
EA
LG
L
V
H
-
QQQS
L
FYKQGVFAATYPGK
-----------
IN
F
MQ
I
A
A
G
F
G
LE
T
CD
L
NNEA
D
PQA
AL
QEIINR
---
PG
P
AL
IHV
R
ID
AE
--------
E
KVY
P
M
V
PP
GA
A
N
T
EM
fig|362663.8.peg.3903
Escherichia coli 536 (19-559/562)
IV
HF
L
EQQ
G
I
KI
V
T
G
IP
G
GS
I
LP
V
Y
D
A
L
SQS
-
T
Q
I
R
HI
LA
RHEQ
G
A
GFI
A
Q
G
M
A
RTD
GK
P
A
V
--
C
MAC
SGPG
A
TN
L
V
T
AI
A
D
A
RL
D
SI
PLI
C
I
T
G
QVSASM
IG
--
T
D
A
FQE
V
D
TY
--------
GISIPIT
K
HNY
LV
RHI
E
E
LP
QV
M
SD
A
FRI
A
Q
S
-
GRPG
P
V
W
I
D
I
P
K
DV
QTAVFEIE
---
TQPAMAEKAAAP-
-
-AFSEE-S
I
RD
A
AAM
I
NA
A
KR
P
V
L
YL
G
G
G
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
TTMT
L
M
A
LG
ML
P
KA
HP
LSL
GM
L
GM
H
G
VRSTNYI
L
Q
E
AD
L
L
IV
L
G
A
RF
DD
R
AIGKTEQ
F
C
P
-
NA
KI
IH
V
DID
R
A
E
L
GKIKQPH
VAI
QA
D
VDDV
L
AQ
L
I
PL
V
EA----Q
P
R
A
--
-E
W
H
Q
LVADL
Q
REFPCPIP--KAC
D
----------------------------
P
-
LSHYGLINA
V
AA
----
CVDDNAII
T
T
DVG
QH
QM
W
T
A
QA
-
YPLNR
PR
QW
L
T
S
G
--------
GL
G
T
MG
F
GLP
A
AIGA
AL
A
N
P
DRK
V
L
C
FS
GDG
SLM
M
NIQ
E
MA
T
AS
E
NQ
L
D
V
K
I
I
LM
NN
EA
LG
L
V
H
-
QQQS
L
FYKQGVFAATYPGK
-----------
IN
F
MQ
I
A
A
G
F
G
LE
T
CD
L
NNEA
D
PQA
AL
QEIINR
---
PG
P
AL
IHV
R
ID
AE
--------
E
KVY
P
M
V
PP
GA
A
N
T
EM
fig|362663.9.peg.3918
Escherichia coli 536 (19-559/562)
IV
HF
L
EQQ
G
I
KI
V
T
G
IP
G
GS
I
LP
V
Y
D
A
L
SQS
-
T
Q
I
R
HI
LA
RHEQ
G
A
GFI
A
Q
G
M
A
RTD
GK
P
A
V
--
C
MAC
SGPG
A
TN
L
V
T
AI
A
D
A
RL
D
SI
PLI
C
I
T
G
QVSASM
IG
--
T
D
A
FQE
V
D
TY
--------
GISIPIT
K
HNY
LV
RHI
E
E
LP
QV
M
SD
A
FRI
A
Q
S
-
GRPG
P
V
W
I
D
I
P
K
DV
QTAVFEIE
---
TQPAMAEKAAAP-
-
-AFSEE-S
I
RD
A
AAM
I
NA
A
KR
P
V
L
YL
G
G
G
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
TTMT
L
M
A
LG
ML
P
KA
HP
LSL
GM
L
GM
H
G
VRSTNYI
L
Q
E
AD
L
L
IV
L
G
A
RF
DD
R
AIGKTEQ
F
C
P
-
NA
KI
IH
V
DID
R
A
E
L
GKIKQPH
VAI
QA
D
VDDV
L
AQ
L
I
PL
V
EA----Q
P
R
A
--
-E
W
H
Q
LVADL
Q
REFPCPIP--KAC
D
----------------------------
P
-
LSHYGLINA
V
AA
----
CVDDNAII
T
T
DVG
QH
QM
W
T
A
QA
-
YPLNR
PR
QW
L
T
S
G
--------
GL
G
T
MG
F
GLP
A
AIGA
AL
A
N
P
DRK
V
L
C
FS
GDG
SLM
M
NIQ
E
MA
T
AS
E
NQ
L
D
V
K
I
I
LM
NN
EA
LG
L
V
H
-
QQQS
L
FYKQGVFAATYPGK
-----------
IN
F
MQ
I
A
A
G
F
G
LE
T
CD
L
NNEA
D
PQA
AL
QEIINR
---
PG
P
AL
IHV
R
ID
AE
--------
E
KVY
P
M
V
PP
GA
A
N
T
EM
fig|670897.3.peg.3588
Escherichia coli 2362-75 (19-559/562)
IV
HF
L
EQQ
G
I
KI
V
T
G
IP
G
GS
I
LP
V
Y
D
A
L
SQS
-
T
Q
I
R
HI
LA
RHEQ
G
A
GFI
A
Q
G
M
A
RTD
GK
P
A
V
--
C
MAC
SGPG
A
TN
L
V
T
AI
A
D
A
RL
D
SI
PLI
C
I
T
G
QVSASM
IG
--
T
D
A
FQE
V
D
TY
--------
GISIPIT
K
HNY
LV
RHI
E
E
LP
QV
M
SD
A
FRI
A
Q
S
-
GRPG
P
V
W
I
D
I
P
K
DV
QTAVFEIE
---
TQPAMAEKAAAP-
-
-AFSEE-S
I
RD
A
AAM
I
NA
A
KR
P
V
L
YL
G
G
G
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
TTMT
L
M
A
LG
ML
P
KA
HP
LSL
GM
L
GM
H
G
VRSTNYI
L
Q
E
AD
L
L
IV
L
G
A
RF
DD
R
AIGKTEQ
F
C
P
-
NA
KI
IH
V
DID
R
A
E
L
GKIKQPH
VAI
QA
D
VDDV
L
AQ
L
I
PL
V
EA----Q
P
R
A
--
-E
W
H
Q
LVADL
Q
REFPCPIP--KAC
D
----------------------------
P
-
LSHYGLINA
V
AA
----
CVDDNAII
T
T
DVG
QH
QM
W
T
A
QA
-
YPLNR
PR
QW
L
T
S
G
--------
GL
G
T
MG
F
GLP
A
AIGA
AL
A
N
P
DRR
V
L
C
FS
GDG
SLM
M
NIQ
E
MA
T
AS
E
NQ
L
D
V
K
I
I
LM
NN
EA
LG
L
V
H
-
QQQS
L
FYKQGVFAATYPGK
-----------
IN
F
MQ
I
A
A
G
F
G
LE
T
CD
L
NNET
D
PQA
AL
QEIINR
---
PG
P
AL
IHV
R
ID
AE
--------
E
KVY
P
M
V
PP
GA
A
N
T
EM
fig|216593.1.peg.4481
Escherichia coli E2348/69 (19-559/562)
IV
HF
L
EQQ
G
I
KI
V
T
G
IP
G
GS
I
LP
V
Y
D
A
L
SQS
-
T
Q
I
R
HI
LA
RHEQ
G
A
GFI
A
Q
G
M
A
RTD
GK
P
A
V
--
C
MAC
SGPG
A
TN
L
V
T
AI
A
D
A
RL
D
SI
PLI
C
I
T
G
QVSASM
IG
--
T
D
A
FQE
V
D
TY
--------
GISIPIT
K
HNY
LV
RHI
E
E
LP
QV
M
SD
A
FRI
A
Q
S
-
GRPG
P
V
W
I
D
I
P
K
DV
QTAVFEIE
---
TQPAMAEKAAAP-
-
-AFSEE-S
I
RD
A
AAM
I
NA
A
KR
P
V
L
YL
G
G
G
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
TTMT
L
M
A
LG
ML
P
KA
HP
LSL
GM
L
GM
H
G
VRSTNYI
L
Q
E
AD
L
L
IV
L
G
A
RF
DD
R
AIGKTEQ
F
C
P
-
NA
KI
IH
V
DID
R
A
E
L
GKIKQPH
VAI
QA
D
VDDV
L
AQ
L
I
PL
V
EA----Q
P
R
A
--
-E
W
H
Q
LVADL
Q
REFPCPIP--KAC
D
----------------------------
P
-
LSHYGLINA
V
AA
----
CVDDNAII
T
T
DVG
QH
QM
W
T
A
QA
-
YPLNR
PR
QW
L
T
S
G
--------
GL
G
T
MG
F
GLP
A
AIGA
AL
A
N
P
DRR
V
L
C
FS
GDG
SLM
M
NIQ
E
MA
T
AS
E
NQ
L
D
V
K
I
I
LM
NN
EA
LG
L
V
H
-
QQQS
L
FYKQGVFAATYPGK
-----------
IN
F
MQ
I
A
A
G
F
G
LE
T
CD
L
NNET
D
PQA
AL
QEIINR
---
PG
P
AL
IHV
R
ID
AE
--------
E
KVY
P
M
V
PP
GA
A
N
T
EM
fig|574521.7.peg.4062
Escherichia coli O127:H6 str. E2348/69 (19-559/562)
IV
HF
L
EQQ
G
I
KI
V
T
G
IP
G
GS
I
LP
V
Y
D
A
L
SQS
-
T
Q
I
R
HI
LA
RHEQ
G
A
GFI
A
Q
G
M
A
RTD
GK
P
A
V
--
C
MAC
SGPG
A
TN
L
V
T
AI
A
D
A
RL
D
SI
PLI
C
I
T
G
QVSASM
IG
--
T
D
A
FQE
V
D
TY
--------
GISIPIT
K
HNY
LV
RHI
E
E
LP
QV
M
SD
A
FRI
A
Q
S
-
GRPG
P
V
W
I
D
I
P
K
DV
QTAVFEIE
---
TQPAMAEKAAAP-
-
-AFSEE-S
I
RD
A
AAM
I
NA
A
KR
P
V
L
YL
G
G
G
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
TTMT
L
M
A
LG
ML
P
KA
HP
LSL
GM
L
GM
H
G
VRSTNYI
L
Q
E
AD
L
L
IV
L
G
A
RF
DD
R
AIGKTEQ
F
C
P
-
NA
KI
IH
V
DID
R
A
E
L
GKIKQPH
VAI
QA
D
VDDV
L
AQ
L
I
PL
V
EA----Q
P
R
A
--
-E
W
H
Q
LVADL
Q
REFPCPIP--KAC
D
----------------------------
P
-
LSHYGLINA
V
AA
----
CVDDNAII
T
T
DVG
QH
QM
W
T
A
QA
-
YPLNR
PR
QW
L
T
S
G
--------
GL
G
T
MG
F
GLP
A
AIGA
AL
A
N
P
DRR
V
L
C
FS
GDG
SLM
M
NIQ
E
MA
T
AS
E
NQ
L
D
V
K
I
I
LM
NN
EA
LG
L
V
H
-
QQQS
L
FYKQGVFAATYPGK
-----------
IN
F
MQ
I
A
A
G
F
G
LE
T
CD
L
NNET
D
PQA
AL
QEIINR
---
PG
P
AL
IHV
R
ID
AE
--------
E
KVY
P
M
V
PP
GA
A
N
T
EM
fig|656417.3.peg.4558
Escherichia coli M605 (19-559/562)
IV
HF
L
EQQ
G
I
KI
V
T
G
IP
G
GS
I
LP
V
Y
D
A
L
SQS
-
T
Q
I
R
HI
LA
RHEQ
G
A
GFI
A
Q
G
M
A
RTD
GK
P
A
V
--
C
MAC
SGPG
A
TN
L
V
T
AI
A
D
A
RL
D
SI
PLI
C
I
T
G
QVSASM
IG
--
T
D
A
FQE
V
D
TY
--------
GISIPIT
K
HNY
LV
RHI
E
E
LP
QV
M
SD
A
FRI
A
Q
S
-
GRPG
P
V
W
I
D
I
P
K
DV
QTAVFDIE
---
TQPAMAEKAAAP-
-
-AFSEE-S
I
RD
A
AAM
I
NA
A
KR
P
V
L
YL
G
G
G
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
TTMT
L
M
A
LG
ML
P
KA
HP
LSL
GM
L
GM
H
G
VRSTNYI
L
Q
E
AD
L
L
IV
L
G
A
RF
DD
R
AIGKTEQ
F
C
P
-
NA
KI
IH
V
DID
R
A
E
L
GKIKQPH
VAI
QA
D
VDDV
L
AQ
L
I
PL
V
EA----Q
P
R
A
--
-E
W
H
Q
LVADL
Q
REFPCPIP--KAC
D
----------------------------
P
-
LSHYGLINA
V
AA
----
CVDDNAII
T
T
DVG
QH
QM
W
T
A
QA
-
YPLNR
PR
QW
L
T
S
G
--------
GL
G
T
MG
F
GLP
A
AIGA
AL
A
N
P
DRK
V
L
C
FS
GDG
SLM
M
NIQ
E
MA
T
AS
E
NQ
L
D
V
K
I
I
LM
NN
EA
LG
L
V
H
-
QQQS
L
FYKQGVFAATYPGK
-----------
IN
F
MQ
I
A
A
G
F
G
LE
T
CD
L
NNEA
D
PQA
AL
QEIINR
---
PG
P
AL
IHV
R
ID
AE
--------
E
KVY
P
M
V
PP
GA
A
N
T
EM
fig|585057.4.peg.4410
Escherichia coli IAI39 (19-559/562)
IV
HF
L
EQQ
G
I
KI
V
T
G
IP
G
GS
I
LP
V
Y
D
A
L
SQS
-
T
Q
I
R
HI
LA
RHEQ
G
A
GFI
A
Q
G
M
A
RTD
GK
P
A
V
--
C
MAC
SGPG
A
TN
L
V
T
AI
A
D
A
RL
D
SI
PLI
C
I
T
G
QVPASM
IG
--
T
D
A
FQE
V
D
TY
--------
GISIPIT
K
YNY
LV
RHI
E
E
LP
QV
M
SD
A
FRI
A
Q
S
-
GRPG
P
V
W
I
D
I
P
K
DV
QTAVFEIE
---
EQPGMTEKAAAP-
-
-AFSEE-S
I
RD
A
AAM
I
NA
A
KR
P
V
L
YL
G
G
G
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
TTMT
L
M
A
LG
ML
P
KA
HP
LSL
GM
L
GM
H
G
VRSTNYI
L
Q
E
AD
L
L
IV
L
G
A
RF
DD
R
AIGKTEQ
F
C
P
-
NA
KI
IH
V
DID
R
A
E
L
GKIKQPH
VAI
QA
D
VDDV
L
AQ
L
I
PQ
V
EA----Q
P
R
A
--
-E
W
H
Q
LVADL
Q
REFPCPIP--KAC
D
----------------------------
P
-
LTHYGLINA
V
AA
----
CVDDNAII
T
T
DVG
QH
QM
W
T
A
QA
-
YPLNR
PR
QW
L
T
S
G
--------
GL
G
T
MG
F
GLP
A
AIGA
AL
A
N
P
DRK
V
L
C
FS
GDG
SLM
M
NIQ
E
MA
T
AS
E
NQ
L
D
V
K
I
I
LM
NN
EA
LG
L
V
H
-
QQQS
L
FYKQGVFAATYPGK
-----------
IN
F
MQ
I
A
A
G
F
G
LE
T
CD
L
NNET
D
PQA
AL
QEIINR
---
PG
P
AL
IHV
R
ID
AE
--------
E
KVY
P
M
V
PP
GA
A
N
T
EM
fig|585057.6.peg.4420
Escherichia coli IAI39 (19-559/562)
IV
HF
L
EQQ
G
I
KI
V
T
G
IP
G
GS
I
LP
V
Y
D
A
L
SQS
-
T
Q
I
R
HI
LA
RHEQ
G
A
GFI
A
Q
G
M
A
RTD
GK
P
A
V
--
C
MAC
SGPG
A
TN
L
V
T
AI
A
D
A
RL
D
SI
PLI
C
I
T
G
QVPASM
IG
--
T
D
A
FQE
V
D
TY
--------
GISIPIT
K
YNY
LV
RHI
E
E
LP
QV
M
SD
A
FRI
A
Q
S
-
GRPG
P
V
W
I
D
I
P
K
DV
QTAVFEIE
---
EQPGMTEKAAAP-
-
-AFSEE-S
I
RD
A
AAM
I
NA
A
KR
P
V
L
YL
G
G
G
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
TTMT
L
M
A
LG
ML
P
KA
HP
LSL
GM
L
GM
H
G
VRSTNYI
L
Q
E
AD
L
L
IV
L
G
A
RF
DD
R
AIGKTEQ
F
C
P
-
NA
KI
IH
V
DID
R
A
E
L
GKIKQPH
VAI
QA
D
VDDV
L
AQ
L
I
PQ
V
EA----Q
P
R
A
--
-E
W
H
Q
LVADL
Q
REFPCPIP--KAC
D
----------------------------
P
-
LTHYGLINA
V
AA
----
CVDDNAII
T
T
DVG
QH
QM
W
T
A
QA
-
YPLNR
PR
QW
L
T
S
G
--------
GL
G
T
MG
F
GLP
A
AIGA
AL
A
N
P
DRK
V
L
C
FS
GDG
SLM
M
NIQ
E
MA
T
AS
E
NQ
L
D
V
K
I
I
LM
NN
EA
LG
L
V
H
-
QQQS
L
FYKQGVFAATYPGK
-----------
IN
F
MQ
I
A
A
G
F
G
LE
T
CD
L
NNET
D
PQA
AL
QEIINR
---
PG
P
AL
IHV
R
ID
AE
--------
E
KVY
P
M
V
PP
GA
A
N
T
EM
fig|525281.3.peg.3174
Escherichia coli 83972 (19-559/562)
IV
HF
L
EQQ
G
I
KI
V
T
G
IP
G
GS
I
LP
V
Y
D
A
L
SQS
-
T
Q
I
R
HI
LA
RHEQ
G
A
GFI
A
Q
G
M
A
RTD
GK
P
A
V
--
C
MAC
SGPG
A
TN
L
V
T
AI
A
D
A
RL
D
SI
PLI
C
I
T
G
QVPASM
IG
--
T
D
A
FQE
V
D
TY
--------
GISIPIT
K
HNY
LV
RHI
E
E
LP
QV
M
SD
A
FRI
A
Q
S
-
GRPG
P
V
W
I
D
I
P
K
DV
QTAVFEIE
---
TQPAMAEKAAAP-
-
-AFSEE-S
I
RD
A
AAM
I
NA
A
KR
P
V
L
YL
G
G
G
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
TTMT
L
M
A
LG
ML
P
KA
HP
LSL
GM
L
GM
H
G
VRSTNYI
L
Q
E
AD
L
L
IV
L
G
A
RF
DD
R
AIGKTEQ
F
C
P
-
NA
KI
IH
V
DID
R
A
E
L
GKIKQPH
VAI
QA
D
VDDV
L
AQ
L
I
PL
V
EA----Q
P
R
A
--
-E
W
H
Q
LVADL
Q
REFPCPIP--KAC
D
----------------------------
P
-
LSHYGLINA
V
AA
----
CVDDNAII
T
T
DVG
QH
QM
W
T
A
QA
-
YPLNR
PR
QW
L
T
S
G
--------
GL
G
T
MG
F
GLP
A
AIGA
AL
A
N
P
DRK
V
L
C
FS
GDG
SLM
M
NIQ
E
MA
T
AS
E
NQ
L
D
V
K
I
I
LM
NN
EA
LG
L
V
H
-
QQQS
L
FYKQGVFAATYPGK
-----------
IN
F
MQ
I
A
A
G
F
G
LE
T
CD
L
NNEA
D
PQA
AL
QEIINR
---
PG
P
AL
IHV
R
ID
AE
--------
E
KVY
P
M
V
PP
GA
A
N
T
EM
fig|655817.3.peg.4346
Escherichia coli ABU 83972 (19-559/562)
IV
HF
L
EQQ
G
I
KI
V
T
G
IP
G
GS
I
LP
V
Y
D
A
L
SQS
-
T
Q
I
R
HI
LA
RHEQ
G
A
GFI
A
Q
G
M
A
RTD
GK
P
A
V
--
C
MAC
SGPG
A
TN
L
V
T
AI
A
D
A
RL
D
SI
PLI
C
I
T
G
QVPASM
IG
--
T
D
A
FQE
V
D
TY
--------
GISIPIT
K
HNY
LV
RHI
E
E
LP
QV
M
SD
A
FRI
A
Q
S
-
GRPG
P
V
W
I
D
I
P
K
DV
QTAVFEIE
---
TQPAMAEKAAAP-
-
-AFSEE-S
I
RD
A
AAM
I
NA
A
KR
P
V
L
YL
G
G
G
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
TTMT
L
M
A
LG
ML
P
KA
HP
LSL
GM
L
GM
H
G
VRSTNYI
L
Q
E
AD
L
L
IV
L
G
A
RF
DD
R
AIGKTEQ
F
C
P
-
NA
KI
IH
V
DID
R
A
E
L
GKIKQPH
VAI
QA
D
VDDV
L
AQ
L
I
PL
V
EA----Q
P
R
A
--
-E
W
H
Q
LVADL
Q
REFPCPIP--KAC
D
----------------------------
P
-
LSHYGLINA
V
AA
----
CVDDNAII
T
T
DVG
QH
QM
W
T
A
QA
-
YPLNR
PR
QW
L
T
S
G
--------
GL
G
T
MG
F
GLP
A
AIGA
AL
A
N
P
DRK
V
L
C
FS
GDG
SLM
M
NIQ
E
MA
T
AS
E
NQ
L
D
V
K
I
I
LM
NN
EA
LG
L
V
H
-
QQQS
L
FYKQGVFAATYPGK
-----------
IN
F
MQ
I
A
A
G
F
G
LE
T
CD
L
NNEA
D
PQA
AL
QEIINR
---
PG
P
AL
IHV
R
ID
AE
--------
E
KVY
P
M
V
PP
GA
A
N
T
EM
fig|199310.1.peg.4499
Escherichia coli CFT073 (19-559/562)
IV
HF
L
EQQ
G
I
KI
V
T
G
IP
G
GS
I
LP
V
Y
D
A
L
SQS
-
T
Q
I
R
HI
LA
RHEQ
G
A
GFI
A
Q
G
M
A
RTD
GK
P
A
V
--
C
MAC
SGPG
A
TN
L
V
T
AI
A
D
A
RL
D
SI
PLI
C
I
T
G
QVPASM
IG
--
T
D
A
FQE
V
D
TY
--------
GISIPIT
K
HNY
LV
RHI
E
E
LP
QV
M
SD
A
FRI
A
Q
S
-
GRPG
P
V
W
I
D
I
P
K
DV
QTAVFEIE
---
TQPAMAEKAAAP-
-
-AFSEE-S
I
RD
A
AAM
I
NA
A
KR
P
V
L
YL
G
G
G
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
TTMT
L
M
A
LG
ML
P
KA
HP
LSL
GM
L
GM
H
G
VRSTNYI
L
Q
E
AD
L
L
IV
L
G
A
RF
DD
R
AIGKTEQ
F
C
P
-
NA
KI
IH
V
DID
R
A
E
L
GKIKQPH
VAI
QA
D
VDDV
L
AQ
L
I
PL
V
EA----Q
P
R
A
--
-E
W
H
Q
LVADL
Q
REFPCPIP--KAC
D
----------------------------
P
-
LSHYGLINA
V
AA
----
CVDDNAII
T
T
DVG
QH
QM
W
T
A
QA
-
YPLNR
PR
QW
L
T
S
G
--------
GL
G
T
MG
F
GLP
A
AIGA
AL
A
N
P
DRK
V
L
C
FS
GDG
SLM
M
NIQ
E
MA
T
AS
E
NQ
L
D
V
K
I
I
LM
NN
EA
LG
L
V
H
-
QQQS
L
FYKQGVFAATYPGK
-----------
IN
F
MQ
I
A
A
G
F
G
LE
T
CD
L
NNEA
D
PQA
AL
QEIINR
---
PG
P
AL
IHV
R
ID
AE
--------
E
KVY
P
M
V
PP
GA
A
N
T
EM
fig|199310.4.peg.4313
Escherichia coli CFT073 (19-559/562)
IV
HF
L
EQQ
G
I
KI
V
T
G
IP
G
GS
I
LP
V
Y
D
A
L
SQS
-
T
Q
I
R
HI
LA
RHEQ
G
A
GFI
A
Q
G
M
A
RTD
GK
P
A
V
--
C
MAC
SGPG
A
TN
L
V
T
AI
A
D
A
RL
D
SI
PLI
C
I
T
G
QVPASM
IG
--
T
D
A
FQE
V
D
TY
--------
GISIPIT
K
HNY
LV
RHI
E
E
LP
QV
M
SD
A
FRI
A
Q
S
-
GRPG
P
V
W
I
D
I
P
K
DV
QTAVFEIE
---
TQPAMAEKAAAP-
-
-AFSEE-S
I
RD
A
AAM
I
NA
A
KR
P
V
L
YL
G
G
G
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
TTMT
L
M
A
LG
ML
P
KA
HP
LSL
GM
L
GM
H
G
VRSTNYI
L
Q
E
AD
L
L
IV
L
G
A
RF
DD
R
AIGKTEQ
F
C
P
-
NA
KI
IH
V
DID
R
A
E
L
GKIKQPH
VAI
QA
D
VDDV
L
AQ
L
I
PL
V
EA----Q
P
R
A
--
-E
W
H
Q
LVADL
Q
REFPCPIP--KAC
D
----------------------------
P
-
LSHYGLINA
V
AA
----
CVDDNAII
T
T
DVG
QH
QM
W
T
A
QA
-
YPLNR
PR
QW
L
T
S
G
--------
GL
G
T
MG
F
GLP
A
AIGA
AL
A
N
P
DRK
V
L
C
FS
GDG
SLM
M
NIQ
E
MA
T
AS
E
NQ
L
D
V
K
I
I
LM
NN
EA
LG
L
V
H
-
QQQS
L
FYKQGVFAATYPGK
-----------
IN
F
MQ
I
A
A
G
F
G
LE
T
CD
L
NNEA
D
PQA
AL
QEIINR
---
PG
P
AL
IHV
R
ID
AE
--------
E
KVY
P
M
V
PP
GA
A
N
T
EM
fig|656393.3.peg.4841
Escherichia coli H299 (19-559/562)
IV
HF
L
EQQ
G
I
KI
V
T
G
IP
G
GS
I
LP
V
Y
D
A
L
SQS
-
T
Q
I
R
HI
LA
RHEQ
G
A
GFI
A
Q
G
M
A
RTD
GK
P
A
V
--
C
MAC
SGPG
A
TN
L
V
T
AI
A
D
A
RL
D
SI
PLI
C
I
T
G
QVPASM
IG
--
T
D
A
FQE
V
D
TY
--------
GISIPIT
K
HNY
LV
RHI
E
E
LP
QV
M
SD
A
FRI
A
Q
S
-
GRPG
P
V
W
I
D
I
P
K
DV
QTAVFEIE
---
TQPAMAEKAAAP-
-
-AFSEE-S
I
RD
A
AAM
I
NA
A
KR
P
V
L
YL
G
G
G
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
TTMT
L
M
A
LG
ML
P
KA
HP
LSL
GM
L
GM
H
G
VRSTNYI
L
Q
E
AD
L
L
IV
L
G
A
RF
DD
R
AIGKTEQ
F
C
P
-
NA
KI
IH
V
DID
R
A
E
L
GKIKQPH
VAI
QA
D
VDDV
L
AQ
L
I
PL
V
EA----Q
P
R
A
--
-E
W
H
Q
LVADL
Q
REFPCPIP--KAC
D
----------------------------
P
-
LSHYGLINA
V
AA
----
CVDDNAII
T
T
DVG
QH
QM
W
T
A
QA
-
YPLNR
PR
QW
L
T
S
G
--------
GL
G
T
MG
F
GLP
A
AIGA
AL
A
N
P
DRK
V
L
C
FS
GDG
SLM
M
NIQ
E
MA
T
AS
E
NQ
L
D
V
K
I
I
LM
NN
EA
LG
L
V
H
-
QQQS
L
FYKQGVFAATYPGK
-----------
IN
F
MQ
I
A
A
G
F
G
LE
T
CD
L
NNEA
D
PQA
AL
QEIINR
---
PG
P
AL
IHV
R
ID
AE
--------
E
KVY
P
M
V
PP
GA
A
N
T
EM
fig|749546.3.peg.1453
Escherichia coli MS 185-1 (19-559/562)
IV
HF
L
EQQ
G
I
KI
V
T
G
IP
G
GS
I
LP
V
Y
D
A
L
SQS
-
T
Q
I
R
HI
LA
RHEQ
G
A
GFI
A
Q
G
M
A
RTD
GK
P
A
V
--
C
MAC
SGPG
A
TN
L
V
T
AI
A
D
A
RL
D
SI
PLI
C
I
T
G
QVPASM
IG
--
T
D
A
FQE
V
D
TY
--------
GISIPIT
K
HNY
LV
RHI
E
E
LP
QV
M
SD
A
FRI
A
Q
S
-
GRPG
P
V
W
I
D
I
P
K
DV
QTAVFEIE
---
TQPAMAEKAAAP-
-
-AFSEE-S
I
RD
A
AAM
I
NA
A
KR
P
V
L
YL
G
G
G
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
TTMT
L
M
A
LG
ML
P
KA
HP
LSL
GM
L
GM
H
G
VRSTNYI
L
Q
E
AD
L
L
IV
L
G
A
RF
DD
R
AIGKTEQ
F
C
P
-
NA
KI
IH
V
DID
R
A
E
L
GKIKQPH
VAI
QA
D
VDDV
L
AQ
L
I
PL
V
EA----Q
P
R
A
--
-E
W
H
Q
LVADL
Q
REFPCPIP--KAC
D
----------------------------
P
-
LSHYGLINA
V
AA
----
CVDDNAII
T
T
DVG
QH
QM
W
T
A
QA
-
YPLNR
PR
QW
L
T
S
G
--------
GL
G
T
MG
F
GLP
A
AIGA
AL
A
N
P
DRK
V
L
C
FS
GDG
SLM
M
NIQ
E
MA
T
AS
E
NQ
L
D
V
K
I
I
LM
NN
EA
LG
L
V
H
-
QQQS
L
FYKQGVFAATYPGK
-----------
IN
F
MQ
I
A
A
G
F
G
LE
T
CD
L
NNEA
D
PQA
AL
QEIINR
---
PG
P
AL
IHV
R
ID
AE
--------
E
KVY
P
M
V
PP
GA
A
N
T
EM
fig|749528.3.peg.2892
Escherichia coli MS 45-1 (19-559/562)
IV
HF
L
EQQ
G
I
KI
V
T
G
IP
G
GS
I
LP
V
Y
D
A
L
SQS
-
T
Q
I
R
HI
LA
RHEQ
G
A
GFI
A
Q
G
M
A
RTD
GK
P
A
V
--
C
MAC
SGPG
A
TN
L
V
T
AI
A
D
A
RL
D
SI
PLI
C
I
T
G
QVPASM
IG
--
T
D
A
FQE
V
D
TY
--------
GISIPIT
K
HNY
LV
RHI
E
E
LP
QV
M
SD
A
FRI
A
Q
S
-
GRPG
P
V
W
I
D
I
P
K
DV
QTAVFEIE
---
TQPAMAEKAAAP-
-
-AFSEE-S
I
RD
A
AAM
I
NA
A
KR
P
V
L
YL
G
G
G
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
TTMT
L
M
A
LG
ML
P
KA
HP
LSL
GM
L
GM
H
G
VRSTNYI
L
Q
E
AD
L
L
IV
L
G
A
RF
DD
R
AIGKTEQ
F
C
P
-
NA
KI
IH
V
DID
R
A
E
L
GKIKQPH
VAI
QA
D
VDDV
L
AQ
L
I
PL
V
EA----Q
P
R
A
--
-E
W
H
Q
LVADL
Q
REFPCPIP--KAC
D
----------------------------
P
-
LSHYGLINA
V
AA
----
CVDDNAII
T
T
DVG
QH
QM
W
T
A
QA
-
YPLNR
PR
QW
L
T
S
G
--------
GL
G
T
MG
F
GLP
A
AIGA
AL
A
N
P
DRK
V
L
C
FS
GDG
SLM
M
NIQ
E
MA
T
AS
E
NQ
L
D
V
K
I
I
LM
NN
EA
LG
L
V
H
-
QQQS
L
FYKQGVFAATYPGK
-----------
IN
F
MQ
I
A
A
G
F
G
LE
T
CD
L
NNEA
D
PQA
AL
QEIINR
---
PG
P
AL
IHV
R
ID
AE
--------
E
KVY
P
M
V
PP
GA
A
N
T
EM
fig|753642.3.peg.4249
Escherichia coli NC101 (19-559/562)
IV
HF
L
EQQ
G
I
KI
V
T
G
IP
G
GS
I
LP
V
Y
D
A
L
SQS
-
T
Q
I
R
HI
LA
RHEQ
G
A
GFI
A
Q
G
M
A
RTD
GK
P
A
V
--
C
MAC
SGPG
A
TN
L
V
T
AI
A
D
A
RL
D
SI
PLI
C
I
T
G
QVPASM
IG
--
T
D
A
FQE
V
D
TY
--------
GISIPIT
K
HNY
LV
RHI
E
E
LP
QV
M
SD
A
FRI
A
Q
S
-
GRPG
P
V
W
I
D
I
P
K
DV
QTAVFEIE
---
TQPAMAEKAAAP-
-
-AFSEE-S
I
RD
A
AAM
I
NA
A
KR
P
V
L
YL
G
G
G
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
TTMT
L
M
A
LG
ML
P
KA
HP
LSL
GM
L
GM
H
G
VRSTNYI
L
Q
E
AD
L
L
IV
L
G
A
RF
DD
R
AIGKTEQ
F
C
P
-
NA
KI
IH
V
DID
R
A
E
L
GKIKQPH
VAI
QA
D
VDDV
L
AQ
L
I
PL
V
EA----Q
P
R
A
--
-E
W
H
Q
LVADL
Q
REFPCPIP--KAC
D
----------------------------
P
-
LSHYGLINA
V
AA
----
CVDDNAII
T
T
DVG
QH
QM
W
T
A
QA
-
YPLNR
PR
QW
L
T
S
G
--------
GL
G
T
MG
F
GLP
A
AIGA
AL
A
N
P
DRK
V
L
C
FS
GDG
SLM
M
NIQ
E
MA
T
AS
E
NQ
L
D
V
K
I
I
LM
NN
EA
LG
L
V
H
-
QQQS
L
FYKQGVFAATYPGK
-----------
IN
F
MQ
I
A
A
G
F
G
LE
T
CD
L
NNEA
D
PQA
AL
QEIINR
---
PG
P
AL
IHV
R
ID
AE
--------
E
KVY
P
M
V
PP
GA
A
N
T
EM
fig|685038.3.peg.3741
Escherichia coli O83:H1 str. NRG 857C (19-559/562)
IV
HF
L
EQQ
G
I
KI
V
T
G
IP
G
GS
I
LP
V
Y
D
A
L
SQS
-
T
Q
I
R
HI
LA
RHEQ
G
A
GFI
A
Q
G
M
A
RTD
GK
P
A
V
--
C
MAC
SGPG
A
TN
L
V
T
AI
A
D
A
RL
D
SI
PLI
C
I
T
G
QVPASM
IG
--
T
D
A
FQE
V
D
TY
--------
GISIPIT
K
HNY
LV
RHI
E
E
LP
QV
M
SD
A
FRI
A
Q
S
-
GRPG
P
V
W
I
D
I
P
K
DV
QTAVFEIE
---
TQPAMAEKAAAP-
-
-AFSEE-S
I
RD
A
AAM
I
NA
A
KR
P
V
L
YL
G
G
G
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
TTMT
L
M
A
LG
ML
P
KA
HP
LSL
GM
L
GM
H
G
VRSTNYI
L
Q
E
AD
L
L
IV
L
G
A
RF
DD
R
AIGKTEQ
F
C
P
-
NA
KI
IH
V
DID
R
A
E
L
GKIKQPH
VAI
QA
D
VDDV
L
AQ
L
I
PL
V
EA----Q
P
R
A
--
-E
W
H
Q
LVADL
Q
REFPCPIP--KAC
D
----------------------------
P
-
LSHYGLINA
V
AA
----
CVDDNAII
T
T
DVG
QH
QM
W
T
A
QA
-
YPLNR
PR
QW
L
T
S
G
--------
GL
G
T
MG
F
GLP
A
AIGA
AL
A
N
P
DRK
V
L
C
FS
GDG
SLM
M
NIQ
E
MA
T
AS
E
NQ
L
D
V
K
I
I
LM
NN
EA
LG
L
V
H
-
QQQS
L
FYKQGVFAATYPGK
-----------
IN
F
MQ
I
A
A
G
F
G
LE
T
CD
L
NNEA
D
PQA
AL
QEIINR
---
PG
P
AL
IHV
R
ID
AE
--------
E
KVY
P
M
V
PP
GA
A
N
T
EM
fig|656440.3.peg.3986
Escherichia coli TA206 (19-559/562)
IV
HF
L
EQQ
G
I
KI
V
T
G
IP
G
GS
I
LP
V
Y
D
A
L
SQS
-
T
Q
I
R
HI
LA
RHEQ
G
A
GFI
A
Q
G
M
A
RTD
GK
P
A
V
--
C
MAC
SGPG
A
TN
L
V
T
AI
A
D
A
RL
D
SI
PLI
C
I
T
G
QVPASM
IG
--
T
D
A
FQE
V
D
TY
--------
GISIPIT
K
HNY
LV
RHI
E
E
LP
QV
M
SD
A
FRI
A
Q
S
-
GRPG
P
V
W
I
D
I
P
K
DV
QTAVFEIE
---
TQPAMAEKAAAP-
-
-AFSEE-S
I
RD
A
AAM
I
NA
A
KR
P
V
L
YL
G
G
G
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
TTMT
L
M
A
LG
ML
P
KA
HP
LSL
GM
L
GM
H
G
VRSTNYI
L
Q
E
AD
L
L
IV
L
G
A
RF
DD
R
AIGKTEQ
F
C
P
-
NA
KI
IH
V
DID
R
A
E
L
GKIKQPH
VAI
QA
D
VDDV
L
AQ
L
I
PL
V
EA----Q
P
R
A
--
-E
W
H
Q
LVADL
Q
REFPCPIP--KAC
D
----------------------------
P
-
LSHYGLINA
V
AA
----
CVDDNAII
T
T
DVG
QH
QM
W
T
A
QA
-
YPLNR
PR
QW
L
T
S
G
--------
GL
G
T
MG
F
GLP
A
AIGA
AL
A
N
P
DRK
V
L
C
FS
GDG
SLM
M
NIQ
E
MA
T
AS
E
NQ
L
D
V
K
I
I
LM
NN
EA
LG
L
V
H
-
QQQS
L
FYKQGVFAATYPGK
-----------
IN
F
MQ
I
A
A
G
F
G
LE
T
CD
L
NNEA
D
PQA
AL
QEIINR
---
PG
P
AL
IHV
R
ID
AE
--------
E
KVY
P
M
V
PP
GA
A
N
T
EM
fig|481805.3.peg.30
Escherichia coli ATCC 8739 (19-559/562)
IV
HF
L
EQQ
G
I
KI
V
T
G
IP
G
GS
I
LP
V
Y
D
A
L
SQS
-
T
Q
I
R
HI
LA
RHEQ
G
A
GFI
A
Q
G
M
A
RTD
GK
P
A
V
--
C
MAC
SGPG
A
TN
L
V
T
AI
A
D
A
RL
D
SI
PLI
C
I
T
G
QVPASM
IG
--
T
D
A
FQE
V
D
TY
--------
GISIPIT
K
HNY
LV
RHI
E
E
LP
QV
M
SD
A
FRI
A
Q
S
-
GRPG
P
V
W
I
D
I
P
K
DV
QTAVFEIE
---
AQPAVAEKAAAP-
-
-AFSEE-S
I
RD
A
ATM
I
NA
A
KR
P
V
L
YL
G
G
G
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
TTMT
L
M
A
LG
ML
P
KA
HP
LSL
GM
L
GM
H
G
VRSTNYI
L
Q
E
AD
L
L
IV
L
G
A
RF
DD
R
AIGKTEQ
F
C
P
-
NA
KI
IH
V
DID
R
A
E
L
GKIKQPH
VAI
QA
D
VDDV
L
AQ
L
I
PL
V
EA----Q
P
R
A
--
-E
W
H
Q
LVADL
Q
REFPCPIP--KAC
D
----------------------------
P
-
LSHYGLINA
V
AA
----
CVDDNAII
T
T
DVG
QH
QM
W
T
A
QA
-
YPLNR
PR
QW
L
T
S
G
--------
GL
G
T
MG
F
GLP
A
AIGA
AL
A
N
P
DRK
V
L
C
FS
GDG
SLM
M
NIQ
E
MA
T
AS
E
NQ
L
D
V
K
I
I
LM
NN
EA
LG
L
V
H
-
QQQS
L
FYEQGVFAATYPGK
-----------
IN
F
MQ
I
A
A
G
F
G
LE
T
CD
L
NNEA
D
PQA
AL
QEIINR
---
PG
P
AL
IHV
R
ID
AE
--------
E
KVY
P
M
V
PP
GA
A
N
T
EM
fig|481805.6.peg.30
Escherichia coli ATCC 8739 (19-559/562)
IV
HF
L
EQQ
G
I
KI
V
T
G
IP
G
GS
I
LP
V
Y
D
A
L
SQS
-
T
Q
I
R
HI
LA
RHEQ
G
A
GFI
A
Q
G
M
A
RTD
GK
P
A
V
--
C
MAC
SGPG
A
TN
L
V
T
AI
A
D
A
RL
D
SI
PLI
C
I
T
G
QVPASM
IG
--
T
D
A
FQE
V
D
TY
--------
GISIPIT
K
HNY
LV
RHI
E
E
LP
QV
M
SD
A
FRI
A
Q
S
-
GRPG
P
V
W
I
D
I
P
K
DV
QTAVFEIE
---
AQPAVAEKAAAP-
-
-AFSEE-S
I
RD
A
ATM
I
NA
A
KR
P
V
L
YL
G
G
G
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
TTMT
L
M
A
LG
ML
P
KA
HP
LSL
GM
L
GM
H
G
VRSTNYI
L
Q
E
AD
L
L
IV
L
G
A
RF
DD
R
AIGKTEQ
F
C
P
-
NA
KI
IH
V
DID
R
A
E
L
GKIKQPH
VAI
QA
D
VDDV
L
AQ
L
I
PL
V
EA----Q
P
R
A
--
-E
W
H
Q
LVADL
Q
REFPCPIP--KAC
D
----------------------------
P
-
LSHYGLINA
V
AA
----
CVDDNAII
T
T
DVG
QH
QM
W
T
A
QA
-
YPLNR
PR
QW
L
T
S
G
--------
GL
G
T
MG
F
GLP
A
AIGA
AL
A
N
P
DRK
V
L
C
FS
GDG
SLM
M
NIQ
E
MA
T
AS
E
NQ
L
D
V
K
I
I
LM
NN
EA
LG
L
V
H
-
QQQS
L
FYEQGVFAATYPGK
-----------
IN
F
MQ
I
A
A
G
F
G
LE
T
CD
L
NNEA
D
PQA
AL
QEIINR
---
PG
P
AL
IHV
R
ID
AE
--------
E
KVY
P
M
V
PP
GA
A
N
T
EM
fig|331112.3.peg.3642
Escherichia coli HS (19-559/562)
IV
HF
L
EQQ
G
I
KI
V
T
G
IP
G
GS
I
LP
V
Y
D
A
L
SQS
-
T
Q
I
R
HI
LA
RHEQ
G
A
GFI
A
Q
G
M
A
RTD
GK
P
A
V
--
C
MAC
SGPG
A
TN
L
V
T
AI
A
D
A
RL
D
SI
PLI
C
I
T
G
QVPASM
IG
--
T
D
A
FQE
V
D
TY
--------
GISIPIT
K
HNY
LV
RHI
E
E
LP
QV
M
SD
A
FRI
A
Q
S
-
GRPG
P
V
W
I
D
I
P
K
DV
QTAVFEIE
---
AQPAVAEKAAAP-
-
-AFSEE-S
I
RD
A
ATM
I
NA
A
KR
P
V
L
YL
G
G
G
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
TTMT
L
M
A
LG
ML
P
KA
HP
LSL
GM
L
GM
H
G
VRSTNYI
L
Q
E
AD
L
L
IV
L
G
A
RF
DD
R
AIGKTEQ
F
C
P
-
NA
KI
IH
V
DID
R
A
E
L
GKIKQPH
VAI
QA
D
VDDV
L
AQ
L
I
PL
V
EA----Q
P
R
A
--
-E
W
H
Q
LVADL
Q
REFPCPIP--KAC
D
----------------------------
P
-
LSHYGLINA
V
AA
----
CVDDNAII
T
T
DVG
QH
QM
W
T
A
QA
-
YPLNR
PR
QW
L
T
S
G
--------
GL
G
T
MG
F
GLP
A
AIGA
AL
A
N
P
DRK
V
L
C
FS
GDG
SLM
M
NIQ
E
MA
T
AS
E
NQ
L
D
V
K
I
I
LM
NN
EA
LG
L
V
H
-
QQQS
L
FYEQGVFAATYPGK
-----------
IN
F
MQ
I
A
A
G
F
G
LE
T
CD
L
NNEA
D
PQA
AL
QEIINR
---
PG
P
AL
IHV
R
ID
AE
--------
E
KVY
P
M
V
PP
GA
A
N
T
EM
fig|331112.6.peg.3796
Escherichia coli HS (19-559/562)
IV
HF
L
EQQ
G
I
KI
V
T
G
IP
G
GS
I
LP
V
Y
D
A
L
SQS
-
T
Q
I
R
HI
LA
RHEQ
G
A
GFI
A
Q
G
M
A
RTD
GK
P
A
V
--
C
MAC
SGPG
A
TN
L
V
T
AI
A
D
A
RL
D
SI
PLI
C
I
T
G
QVPASM
IG
--
T
D
A
FQE
V
D
TY
--------
GISIPIT
K
HNY
LV
RHI
E
E
LP
QV
M
SD
A
FRI
A
Q
S
-
GRPG
P
V
W
I
D
I
P
K
DV
QTAVFEIE
---
AQPAVAEKAAAP-
-
-AFSEE-S
I
RD
A
ATM
I
NA
A
KR
P
V
L
YL
G
G
G
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
TTMT
L
M
A
LG
ML
P
KA
HP
LSL
GM
L
GM
H
G
VRSTNYI
L
Q
E
AD
L
L
IV
L
G
A
RF
DD
R
AIGKTEQ
F
C
P
-
NA
KI
IH
V
DID
R
A
E
L
GKIKQPH
VAI
QA
D
VDDV
L
AQ
L
I
PL
V
EA----Q
P
R
A
--
-E
W
H
Q
LVADL
Q
REFPCPIP--KAC
D
----------------------------
P
-
LSHYGLINA
V
AA
----
CVDDNAII
T
T
DVG
QH
QM
W
T
A
QA
-
YPLNR
PR
QW
L
T
S
G
--------
GL
G
T
MG
F
GLP
A
AIGA
AL
A
N
P
DRK
V
L
C
FS
GDG
SLM
M
NIQ
E
MA
T
AS
E
NQ
L
D
V
K
I
I
LM
NN
EA
LG
L
V
H
-
QQQS
L
FYEQGVFAATYPGK
-----------
IN
F
MQ
I
A
A
G
F
G
LE
T
CD
L
NNEA
D
PQA
AL
QEIINR
---
PG
P
AL
IHV
R
ID
AE
--------
E
KVY
P
M
V
PP
GA
A
N
T
EM
fig|656419.3.peg.4728
Escherichia coli M718 (19-559/562)
IV
HF
L
EQQ
G
I
KI
V
T
G
IP
G
GS
I
LP
V
Y
D
A
L
SQS
-
T
Q
I
R
HI
LA
RHEQ
G
A
GFI
A
Q
G
M
A
RTD
GK
P
A
V
--
C
MAC
SGPG
A
TN
L
V
T
AI
A
D
A
RL
D
SI
PLI
C
I
T
G
QVPASM
IG
--
T
D
A
FQE
V
D
TY
--------
GISIPIT
K
HNY
LV
RHI
E
E
LP
QV
M
SD
A
FRI
A
Q
S
-
GRPG
P
V
W
I
D
I
P
K
DV
QTAVFEIE
---
AQPAVAEKAAAP-
-
-AFSEE-S
I
RD
A
ATM
I
NA
A
KR
P
V
L
YL
G
G
G
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
TTMT
L
M
A
LG
ML
P
KA
HP
LSL
GM
L
GM
H
G
VRSTNYI
L
Q
E
AD
L
L
IV
L
G
A
RF
DD
R
AIGKTEQ
F
C
P
-
NA
KI
IH
V
DID
R
A
E
L
GKIKQPH
VAI
QA
D
VDDV
L
AQ
L
I
PL
V
EA----Q
P
R
A
--
-E
W
H
Q
LVADL
Q
REFPCPIP--KAC
D
----------------------------
P
-
LSHYGLINA
V
AA
----
CVDDNAII
T
T
DVG
QH
QM
W
T
A
QA
-
YPLNR
PR
QW
L
T
S
G
--------
GL
G
T
MG
F
GLP
A
AIGA
AL
A
N
P
DRK
V
L
C
FS
GDG
SLM
M
NIQ
E
MA
T
AS
E
NQ
L
D
V
K
I
I
LM
NN
EA
LG
L
V
H
-
QQQS
L
FYEQGVFAATYPGK
-----------
IN
F
MQ
I
A
A
G
F
G
LE
T
CD
L
NNEA
D
PQA
AL
QEIINR
---
PG
P
AL
IHV
R
ID
AE
--------
E
KVY
P
M
V
PP
GA
A
N
T
EM
fig|550676.3.peg.3887
Escherichia coli B185 (19-559/562)
IV
HF
L
EQQ
G
I
KI
V
T
G
IP
G
GS
I
LP
V
Y
D
A
L
SQS
-
T
Q
I
R
HI
LA
RHEQ
G
A
GFI
A
Q
G
M
A
RTD
GK
P
A
V
--
C
MAC
SGPG
A
TN
L
V
T
AI
A
D
A
RL
D
SI
PLI
C
I
T
G
QVPASM
IG
--
T
D
A
FQE
V
D
TY
--------
GISIPIT
K
HNY
LV
RHI
E
E
LP
QV
M
SD
A
FRI
A
Q
S
-
GRPG
P
V
W
I
D
I
P
K
DV
QTAVFEIE
---
AQPAVAEKAAAP-
-
-AFSEE-S
I
RD
A
AAM
I
NA
A
KR
P
V
L
YL
G
G
G
VIN
A
P
V
--R
V
R
E
LAEKAQL
P
TTMT
L
M
A
LG
ML
P
KA
HP
LSL
GM
L
GM
H
G
VRSTNYI
L
Q
E
AD
L
L
IV
L
G
A
RF
DD
R
AIGKTEQ
F
C
P
-
NA
KI
IH
V
DID
R
A
E
L
GKIKQPH
VAI
QA
D
VDDV
L
AQ
L
I
PL
V
EA----Q
P
R
A
--
-E
W
H
Q
LVADL
Q
REFPCPIP--KAC
D
----------------------------
P
-
LSHYGLINA
V
AA
----
CVDDNAII
T
T
DVG
QH
QM
W
T
A
QA
-
YPLNR
PR
QW
L
T
S
G
--------
GL
G
T
MG
F
GLP
A
AIGA
AL
A
N
P
DRK
V
L
C
FS
GDG
SLM
M
NIQ
E
MA
T
AS
E
NQ
L
D
V
K
I
I
LM
NN
EA
LG
L
V
H
-
QQQS
L
FYKQGVFAATYPGK
-----------
IN
F
MQ
I
A
A
G
F
G
LE
T
CD
L
NNEA
D
PQA
AL
QEIINR
---
PG
P
AL
IHV
R
ID
AE
--------
E
KVY
P
M
V
PP
GA
A
N
T
EM
fig|358709.5.peg.89
Escherichia coli 101-1 (19-559/562)
IV
HF
L
EQQ
G
I
KI
V
T
G
IP
G
GS
I
LP
V
Y
D
A
L
SQS
-
T
Q
I
R
HI
LA
RHEQ
G
A
GFI
A
Q
G
M
A
RTD
GK
P
A
V
--
C
MAC
SGPG
A
TN
L
V
T
AI
A
D
A
RL
D
SI
PLI
C
I
T
G
QVPASM
IG
--
T
D
A
FQE
V
D
TY
--------
GISIPIT
K
HNY
LV
RHI
E
E
LP
QV
M
SD
A
FRI
A
Q
S
-
GRPG
P
V
W
I
D
I
P
K
DV
QTAVFEIE
---
TQPAMAEKAAAP-
-
-AFSEE-S
I
RD
A
AAM
I
NA
A
KR
P
V
L
YL
G
G
G
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
TTMT
L
M
A
LG
ML
P
KA
HP
LSL
GM
L
GM
H
G
VRSTNYI
L
Q
E
AD
L
L
IV
L
G
A
RF
DD
R
AIGKTEQ
F
C
P
-
NA
KI
IH
V
DID
R
A
E
L
GKIKQPH
VAI
QA
D
VDDV
L
AQ
L
I
PL
V
EA----Q
P
R
A
--
-E
W
H
Q
LVADL
Q
REFPCPIP--KAC
D
----------------------------
P
-
LSHYGLINA
V
AA
----
CVDDNAII
T
T
DVG
QH
QM
W
T
A
QA
-
YPLNR
PR
QW
L
T
S
G
--------
GL
G
T
MG
F
GLP
A
AIGA
AL
A
N
P
DRK
V
L
C
FS
GDG
SLM
M
NIQ
E
MA
T
AS
E
NQ
L
D
V
K
I
I
LM
NN
EA
LG
L
V
H
-
QQQS
L
FYEQGVFAATYPGK
-----------
IN
F
MQ
I
A
A
G
F
G
LE
T
CD
L
NNEA
D
PQA
S
L
QEIINR
---
PG
P
AL
IHV
R
ID
AE
--------
E
KVY
P
M
V
PP
GA
A
N
T
EM
fig|344610.3.peg.1893
Escherichia coli 53638 (19-559/562)
IV
HF
L
EQQ
G
I
KI
V
T
G
IP
G
GS
I
LP
V
Y
D
A
L
SQS
-
T
Q
I
R
HI
LA
RHEQ
G
A
GFI
A
Q
G
M
A
RTD
GK
P
A
V
--
C
MAC
SGPG
A
TN
L
V
T
AI
A
D
A
RL
D
SI
PLI
C
I
T
G
QVPASM
IG
--
T
D
A
FQE
V
D
TY
--------
GISIPIT
K
HNY
LV
RHI
E
E
LP
QV
M
SD
A
FRI
A
Q
S
-
GRPG
P
V
W
I
D
I
P
K
DV
QTAVFEIE
---
TQPAMAEKAAAP-
-
-AFSEE-S
I
RD
A
AAM
I
NA
A
KR
P
V
L
YL
G
G
G
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
TTMT
L
M
A
LG
ML
P
KA
HP
LSL
GM
L
GM
H
G
VRSTNYI
L
Q
E
AD
L
L
IV
L
G
A
RF
DD
R
AIGKTEQ
F
C
P
-
NA
KI
IH
V
DID
R
A
E
L
GKIKQPH
VAI
QA
D
VDDV
L
AQ
L
I
PL
V
EA----Q
P
R
A
--
-E
W
H
Q
LVADL
Q
REFPCPIP--KAC
D
----------------------------
P
-
LSHYGLINA
V
AA
----
CVDDNAII
T
T
DVG
QH
QM
W
T
A
QA
-
YPLNR
PR
QW
L
T
S
G
--------
GL
G
T
MG
F
GLP
A
AIGA
AL
A
N
P
DRK
V
L
C
FS
GDG
SLM
M
NIQ
E
MA
T
AS
E
NQ
L
D
V
K
I
I
LM
NN
EA
LG
L
V
H
-
QQQS
L
FYEQGVFAATYPGK
-----------
IN
F
MQ
I
A
A
G
F
G
LE
T
CD
L
NNEA
D
PQA
S
L
QEIINR
---
PG
P
AL
IHV
R
ID
AE
--------
E
KVY
P
M
V
PP
GA
A
N
T
EM
fig|344610.7.peg.2527
Escherichia coli 53638 (19-559/562)
IV
HF
L
EQQ
G
I
KI
V
T
G
IP
G
GS
I
LP
V
Y
D
A
L
SQS
-
T
Q
I
R
HI
LA
RHEQ
G
A
GFI
A
Q
G
M
A
RTD
GK
P
A
V
--
C
MAC
SGPG
A
TN
L
V
T
AI
A
D
A
RL
D
SI
PLI
C
I
T
G
QVPASM
IG
--
T
D
A
FQE
V
D
TY
--------
GISIPIT
K
HNY
LV
RHI
E
E
LP
QV
M
SD
A
FRI
A
Q
S
-
GRPG
P
V
W
I
D
I
P
K
DV
QTAVFEIE
---
TQPAMAEKAAAP-
-
-AFSEE-S
I
RD
A
AAM
I
NA
A
KR
P
V
L
YL
G
G
G
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
TTMT
L
M
A
LG
ML
P
KA
HP
LSL
GM
L
GM
H
G
VRSTNYI
L
Q
E
AD
L
L
IV
L
G
A
RF
DD
R
AIGKTEQ
F
C
P
-
NA
KI
IH
V
DID
R
A
E
L
GKIKQPH
VAI
QA
D
VDDV
L
AQ
L
I
PL
V
EA----Q
P
R
A
--
-E
W
H
Q
LVADL
Q
REFPCPIP--KAC
D
----------------------------
P
-
LSHYGLINA
V
AA
----
CVDDNAII
T
T
DVG
QH
QM
W
T
A
QA
-
YPLNR
PR
QW
L
T
S
G
--------
GL
G
T
MG
F
GLP
A
AIGA
AL
A
N
P
DRK
V
L
C
FS
GDG
SLM
M
NIQ
E
MA
T
AS
E
NQ
L
D
V
K
I
I
LM
NN
EA
LG
L
V
H
-
QQQS
L
FYEQGVFAATYPGK
-----------
IN
F
MQ
I
A
A
G
F
G
LE
T
CD
L
NNEA
D
PQA
S
L
QEIINR
---
PG
P
AL
IHV
R
ID
AE
--------
E
KVY
P
M
V
PP
GA
A
N
T
EM
fig|413997.3.peg.3732
Escherichia coli B str. REL606 (19-559/562)
IV
HF
L
EQQ
G
I
KI
V
T
G
IP
G
GS
I
LP
V
Y
D
A
L
SQS
-
T
Q
I
R
HI
LA
RHEQ
G
A
GFI
A
Q
G
M
A
RTD
GK
P
A
V
--
C
MAC
SGPG
A
TN
L
V
T
AI
A
D
A
RL
D
SI
PLI
C
I
T
G
QVPASM
IG
--
T
D
A
FQE
V
D
TY
--------
GISIPIT
K
HNY
LV
RHI
E
E
LP
QV
M
SD
A
FRI
A
Q
S
-
GRPG
P
V
W
I
D
I
P
K
DV
QTAVFEIE
---
TQPAMAEKAAAP-
-
-AFSEE-S
I
RD
A
AAM
I
NA
A
KR
P
V
L
YL
G
G
G
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
TTMT
L
M
A
LG
ML
P
KA
HP
LSL
GM
L
GM
H
G
VRSTNYI
L
Q
E
AD
L
L
IV
L
G
A
RF
DD
R
AIGKTEQ
F
C
P
-
NA
KI
IH
V
DID
R
A
E
L
GKIKQPH
VAI
QA
D
VDDV
L
AQ
L
I
PL
V
EA----Q
P
R
A
--
-E
W
H
Q
LVADL
Q
REFPCPIP--KAC
D
----------------------------
P
-
LSHYGLINA
V
AA
----
CVDDNAII
T
T
DVG
QH
QM
W
T
A
QA
-
YPLNR
PR
QW
L
T
S
G
--------
GL
G
T
MG
F
GLP
A
AIGA
AL
A
N
P
DRK
V
L
C
FS
GDG
SLM
M
NIQ
E
MA
T
AS
E
NQ
L
D
V
K
I
I
LM
NN
EA
LG
L
V
H
-
QQQS
L
FYEQGVFAATYPGK
-----------
IN
F
MQ
I
A
A
G
F
G
LE
T
CD
L
NNEA
D
PQA
S
L
QEIINR
---
PG
P
AL
IHV
R
ID
AE
--------
E
KVY
P
M
V
PP
GA
A
N
T
EM
fig|511693.5.peg.3751
Escherichia coli BL21 (19-559/562)
IV
HF
L
EQQ
G
I
KI
V
T
G
IP
G
GS
I
LP
V
Y
D
A
L
SQS
-
T
Q
I
R
HI
LA
RHEQ
G
A
GFI
A
Q
G
M
A
RTD
GK
P
A
V
--
C
MAC
SGPG
A
TN
L
V
T
AI
A
D
A
RL
D
SI
PLI
C
I
T
G
QVPASM
IG
--
T
D
A
FQE
V
D
TY
--------
GISIPIT
K
HNY
LV
RHI
E
E
LP
QV
M
SD
A
FRI
A
Q
S
-
GRPG
P
V
W
I
D
I
P
K
DV
QTAVFEIE
---
TQPAMAEKAAAP-
-
-AFSEE-S
I
RD
A
AAM
I
NA
A
KR
P
V
L
YL
G
G
G
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
TTMT
L
M
A
LG
ML
P
KA
HP
LSL
GM
L
GM
H
G
VRSTNYI
L
Q
E
AD
L
L
IV
L
G
A
RF
DD
R
AIGKTEQ
F
C
P
-
NA
KI
IH
V
DID
R
A
E
L
GKIKQPH
VAI
QA
D
VDDV
L
AQ
L
I
PL
V
EA----Q
P
R
A
--
-E
W
H
Q
LVADL
Q
REFPCPIP--KAC
D
----------------------------
P
-
LSHYGLINA
V
AA
----
CVDDNAII
T
T
DVG
QH
QM
W
T
A
QA
-
YPLNR
PR
QW
L
T
S
G
--------
GL
G
T
MG
F
GLP
A
AIGA
AL
A
N
P
DRK
V
L
C
FS
GDG
SLM
M
NIQ
E
MA
T
AS
E
NQ
L
D
V
K
I
I
LM
NN
EA
LG
L
V
H
-
QQQS
L
FYEQGVFAATYPGK
-----------
IN
F
MQ
I
A
A
G
F
G
LE
T
CD
L
NNEA
D
PQA
S
L
QEIINR
---
PG
P
AL
IHV
R
ID
AE
--------
E
KVY
P
M
V
PP
GA
A
N
T
EM
fig|469008.4.peg.34
Escherichia coli BL21(DE3) (19-559/562)
IV
HF
L
EQQ
G
I
KI
V
T
G
IP
G
GS
I
LP
V
Y
D
A
L
SQS
-
T
Q
I
R
HI
LA
RHEQ
G
A
GFI
A
Q
G
M
A
RTD
GK
P
A
V
--
C
MAC
SGPG
A
TN
L
V
T
AI
A
D
A
RL
D
SI
PLI
C
I
T
G
QVPASM
IG
--
T
D
A
FQE
V
D
TY
--------
GISIPIT
K
HNY
LV
RHI
E
E
LP
QV
M
SD
A
FRI
A
Q
S
-
GRPG
P
V
W
I
D
I
P
K
DV
QTAVFEIE
---
TQPAMAEKAAAP-
-
-AFSEE-S
I
RD
A
AAM
I
NA
A
KR
P
V
L
YL
G
G
G
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
TTMT
L
M
A
LG
ML
P
KA
HP
LSL
GM
L
GM
H
G
VRSTNYI
L
Q
E
AD
L
L
IV
L
G
A
RF
DD
R
AIGKTEQ
F
C
P
-
NA
KI
IH
V
DID
R
A
E
L
GKIKQPH
VAI
QA
D
VDDV
L
AQ
L
I
PL
V
EA----Q
P
R
A
--
-E
W
H
Q
LVADL
Q
REFPCPIP--KAC
D
----------------------------
P
-
LSHYGLINA
V
AA
----
CVDDNAII
T
T
DVG
QH
QM
W
T
A
QA
-
YPLNR
PR
QW
L
T
S
G
--------
GL
G
T
MG
F
GLP
A
AIGA
AL
A
N
P
DRK
V
L
C
FS
GDG
SLM
M
NIQ
E
MA
T
AS
E
NQ
L
D
V
K
I
I
LM
NN
EA
LG
L
V
H
-
QQQS
L
FYEQGVFAATYPGK
-----------
IN
F
MQ
I
A
A
G
F
G
LE
T
CD
L
NNEA
D
PQA
S
L
QEIINR
---
PG
P
AL
IHV
R
ID
AE
--------
E
KVY
P
M
V
PP
GA
A
N
T
EM
fig|595496.3.peg.3675
Escherichia coli BW2952 (19-559/562)
IV
HF
L
EQQ
G
I
KI
V
T
G
IP
G
GS
I
LP
V
Y
D
A
L
SQS
-
T
Q
I
R
HI
LA
RHEQ
G
A
GFI
A
Q
G
M
A
RTD
GK
P
A
V
--
C
MAC
SGPG
A
TN
L
V
T
AI
A
D
A
RL
D
SI
PLI
C
I
T
G
QVPASM
IG
--
T
D
A
FQE
V
D
TY
--------
GISIPIT
K
HNY
LV
RHI
E
E
LP
QV
M
SD
A
FRI
A
Q
S
-
GRPG
P
V
W
I
D
I
P
K
DV
QTAVFEIE
---
TQPAMAEKAAAP-
-
-AFSEE-S
I
RD
A
AAM
I
NA
A
KR
P
V
L
YL
G
G
G
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
TTMT
L
M
A
LG
ML
P
KA
HP
LSL
GM
L
GM
H
G
VRSTNYI
L
Q
E
AD
L
L
IV
L
G
A
RF
DD
R
AIGKTEQ
F
C
P
-
NA
KI
IH
V
DID
R
A
E
L
GKIKQPH
VAI
QA
D
VDDV
L
AQ
L
I
PL
V
EA----Q
P
R
A
--
-E
W
H
Q
LVADL
Q
REFPCPIP--KAC
D
----------------------------
P
-
LSHYGLINA
V
AA
----
CVDDNAII
T
T
DVG
QH
QM
W
T
A
QA
-
YPLNR
PR
QW
L
T
S
G
--------
GL
G
T
MG
F
GLP
A
AIGA
AL
A
N
P
DRK
V
L
C
FS
GDG
SLM
M
NIQ
E
MA
T
AS
E
NQ
L
D
V
K
I
I
LM
NN
EA
LG
L
V
H
-
QQQS
L
FYEQGVFAATYPGK
-----------
IN
F
MQ
I
A
A
G
F
G
LE
T
CD
L
NNEA
D
PQA
S
L
QEIINR
---
PG
P
AL
IHV
R
ID
AE
--------
E
KVY
P
M
V
PP
GA
A
N
T
EM
fig|536056.3.peg.34
Escherichia coli DH1 (19-559/562)
IV
HF
L
EQQ
G
I
KI
V
T
G
IP
G
GS
I
LP
V
Y
D
A
L
SQS
-
T
Q
I
R
HI
LA
RHEQ
G
A
GFI
A
Q
G
M
A
RTD
GK
P
A
V
--
C
MAC
SGPG
A
TN
L
V
T
AI
A
D
A
RL
D
SI
PLI
C
I
T
G
QVPASM
IG
--
T
D
A
FQE
V
D
TY
--------
GISIPIT
K
HNY
LV
RHI
E
E
LP
QV
M
SD
A
FRI
A
Q
S
-
GRPG
P
V
W
I
D
I
P
K
DV
QTAVFEIE
---
TQPAMAEKAAAP-
-
-AFSEE-S
I
RD
A
AAM
I
NA
A
KR
P
V
L
YL
G
G
G
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
TTMT
L
M
A
LG
ML
P
KA
HP
LSL
GM
L
GM
H
G
VRSTNYI
L
Q
E
AD
L
L
IV
L
G
A
RF
DD
R
AIGKTEQ
F
C
P
-
NA
KI
IH
V
DID
R
A
E
L
GKIKQPH
VAI
QA
D
VDDV
L
AQ
L
I
PL
V
EA----Q
P
R
A
--
-E
W
H
Q
LVADL
Q
REFPCPIP--KAC
D
----------------------------
P
-
LSHYGLINA
V
AA
----
CVDDNAII
T
T
DVG
QH
QM
W
T
A
QA
-
YPLNR
PR
QW
L
T
S
G
--------
GL
G
T
MG
F
GLP
A
AIGA
AL
A
N
P
DRK
V
L
C
FS
GDG
SLM
M
NIQ
E
MA
T
AS
E
NQ
L
D
V
K
I
I
LM
NN
EA
LG
L
V
H
-
QQQS
L
FYEQGVFAATYPGK
-----------
IN
F
MQ
I
A
A
G
F
G
LE
T
CD
L
NNEA
D
PQA
S
L
QEIINR
---
PG
P
AL
IHV
R
ID
AE
--------
E
KVY
P
M
V
PP
GA
A
N
T
EM
fig|316401.4.peg.4497
Escherichia coli ETEC H10407 (19-559/562)
IV
HF
L
EQQ
G
I
KI
V
T
G
IP
G
GS
I
LP
V
Y
D
A
L
SQS
-
T
Q
I
R
HI
LA
RHEQ
G
A
GFI
A
Q
G
M
A
RTD
GK
P
A
V
--
C
MAC
SGPG
A
TN
L
V
T
AI
A
D
A
RL
D
SI
PLI
C
I
T
G
QVPASM
IG
--
T
D
A
FQE
V
D
TY
--------
GISIPIT
K
HNY
LV
RHI
E
E
LP
QV
M
SD
A
FRI
A
Q
S
-
GRPG
P
V
W
I
D
I
P
K
DV
QTAVFEIE
---
TQPAMAEKAAAP-
-
-AFSEE-S
I
RD
A
AAM
I
NA
A
KR
P
V
L
YL
G
G
G
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
TTMT
L
M
A
LG
ML
P
KA
HP
LSL
GM
L
GM
H
G
VRSTNYI
L
Q
E
AD
L
L
IV
L
G
A
RF
DD
R
AIGKTEQ
F
C
P
-
NA
KI
IH
V
DID
R
A
E
L
GKIKQPH
VAI
QA
D
VDDV
L
AQ
L
I
PL
V
EA----Q
P
R
A
--
-E
W
H
Q
LVADL
Q
REFPCPIP--KAC
D
----------------------------
P
-
LSHYGLINA
V
AA
----
CVDDNAII
T
T
DVG
QH
QM
W
T
A
QA
-
YPLNR
PR
QW
L
T
S
G
--------
GL
G
T
MG
F
GLP
A
AIGA
AL
A
N
P
DRK
V
L
C
FS
GDG
SLM
M
NIQ
E
MA
T
AS
E
NQ
L
D
V
K
I
I
LM
NN
EA
LG
L
V
H
-
QQQS
L
FYEQGVFAATYPGK
-----------
IN
F
MQ
I
A
A
G
F
G
LE
T
CD
L
NNEA
D
PQA
S
L
QEIINR
---
PG
P
AL
IHV
R
ID
AE
--------
E
KVY
P
M
V
PP
GA
A
N
T
EM
fig|656414.3.peg.4194
Escherichia coli H736 (19-559/562)
IV
HF
L
EQQ
G
I
KI
V
T
G
IP
G
GS
I
LP
V
Y
D
A
L
SQS
-
T
Q
I
R
HI
LA
RHEQ
G
A
GFI
A
Q
G
M
A
RTD
GK
P
A
V
--
C
MAC
SGPG
A
TN
L
V
T
AI
A
D
A
RL
D
SI
PLI
C
I
T
G
QVPASM
IG
--
T
D
A
FQE
V
D
TY
--------
GISIPIT
K
HNY
LV
RHI
E
E
LP
QV
M
SD
A
FRI
A
Q
S
-
GRPG
P
V
W
I
D
I
P
K
DV
QTAVFEIE
---
TQPAMAEKAAAP-
-
-AFSEE-S
I
RD
A
AAM
I
NA
A
KR
P
V
L
YL
G
G
G
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
TTMT
L
M
A
LG
ML
P
KA
HP
LSL
GM
L
GM
H
G
VRSTNYI
L
Q
E
AD
L
L
IV
L
G
A
RF
DD
R
AIGKTEQ
F
C
P
-
NA
KI
IH
V
DID
R
A
E
L
GKIKQPH
VAI
QA
D
VDDV
L
AQ
L
I
PL
V
EA----Q
P
R
A
--
-E
W
H
Q
LVADL
Q
REFPCPIP--KAC
D
----------------------------
P
-
LSHYGLINA
V
AA
----
CVDDNAII
T
T
DVG
QH
QM
W
T
A
QA
-
YPLNR
PR
QW
L
T
S
G
--------
GL
G
T
MG
F
GLP
A
AIGA
AL
A
N
P
DRK
V
L
C
FS
GDG
SLM
M
NIQ
E
MA
T
AS
E
NQ
L
D
V
K
I
I
LM
NN
EA
LG
L
V
H
-
QQQS
L
FYEQGVFAATYPGK
-----------
IN
F
MQ
I
A
A
G
F
G
LE
T
CD
L
NNEA
D
PQA
S
L
QEIINR
---
PG
P
AL
IHV
R
ID
AE
--------
E
KVY
P
M
V
PP
GA
A
N
T
EM
fig|83333.1.peg.3608
Escherichia coli K12 (19-559/562)
IV
HF
L
EQQ
G
I
KI
V
T
G
IP
G
GS
I
LP
V
Y
D
A
L
SQS
-
T
Q
I
R
HI
LA
RHEQ
G
A
GFI
A
Q
G
M
A
RTD
GK
P
A
V
--
C
MAC
SGPG
A
TN
L
V
T
AI
A
D
A
RL
D
SI
PLI
C
I
T
G
QVPASM
IG
--
T
D
A
FQE
V
D
TY
--------
GISIPIT
K
HNY
LV
RHI
E
E
LP
QV
M
SD
A
FRI
A
Q
S
-
GRPG
P
V
W
I
D
I
P
K
DV
QTAVFEIE
---
TQPAMAEKAAAP-
-
-AFSEE-S
I
RD
A
AAM
I
NA
A
KR
P
V
L
YL
G
G
G
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
TTMT
L
M
A
LG
ML
P
KA
HP
LSL
GM
L
GM
H
G
VRSTNYI
L
Q
E
AD
L
L
IV
L
G
A
RF
DD
R
AIGKTEQ
F
C
P
-
NA
KI
IH
V
DID
R
A
E
L
GKIKQPH
VAI
QA
D
VDDV
L
AQ
L
I
PL
V
EA----Q
P
R
A
--
-E
W
H
Q
LVADL
Q
REFPCPIP--KAC
D
----------------------------
P
-
LSHYGLINA
V
AA
----
CVDDNAII
T
T
DVG
QH
QM
W
T
A
QA
-
YPLNR
PR
QW
L
T
S
G
--------
GL
G
T
MG
F
GLP
A
AIGA
AL
A
N
P
DRK
V
L
C
FS
GDG
SLM
M
NIQ
E
MA
T
AS
E
NQ
L
D
V
K
I
I
LM
NN
EA
LG
L
V
H
-
QQQS
L
FYEQGVFAATYPGK
-----------
IN
F
MQ
I
A
A
G
F
G
LE
T
CD
L
NNEA
D
PQA
S
L
QEIINR
---
PG
P
AL
IHV
R
ID
AE
--------
E
KVY
P
M
V
PP
GA
A
N
T
EM
fig|749538.3.peg.3194
Escherichia coli MS 116-1 (19-559/562)
IV
HF
L
EQQ
G
I
KI
V
T
G
IP
G
GS
I
LP
V
Y
D
A
L
SQS
-
T
Q
I
R
HI
LA
RHEQ
G
A
GFI
A
Q
G
M
A
RTD
GK
P
A
V
--
C
MAC
SGPG
A
TN
L
V
T
AI
A
D
A
RL
D
SI
PLI
C
I
T
G
QVPASM
IG
--
T
D
A
FQE
V
D
TY
--------
GISIPIT
K
HNY
LV
RHI
E
E
LP
QV
M
SD
A
FRI
A
Q
S
-
GRPG
P
V
W
I
D
I
P
K
DV
QTAVFEIE
---
TQPAMAEKAAAP-
-
-AFSEE-S
I
RD
A
AAM
I
NA
A
KR
P
V
L
YL
G
G
G
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
TTMT
L
M
A
LG
ML
P
KA
HP
LSL
GM
L
GM
H
G
VRSTNYI
L
Q
E
AD
L
L
IV
L
G
A
RF
DD
R
AIGKTEQ
F
C
P
-
NA
KI
IH
V
DID
R
A
E
L
GKIKQPH
VAI
QA
D
VDDV
L
AQ
L
I
PL
V
EA----Q
P
R
A
--
-E
W
H
Q
LVADL
Q
REFPCPIP--KAC
D
----------------------------
P
-
LSHYGLINA
V
AA
----
CVDDNAII
T
T
DVG
QH
QM
W
T
A
QA
-
YPLNR
PR
QW
L
T
S
G
--------
GL
G
T
MG
F
GLP
A
AIGA
AL
A
N
P
DRK
V
L
C
FS
GDG
SLM
M
NIQ
E
MA
T
AS
E
NQ
L
D
V
K
I
I
LM
NN
EA
LG
L
V
H
-
QQQS
L
FYEQGVFAATYPGK
-----------
IN
F
MQ
I
A
A
G
F
G
LE
T
CD
L
NNEA
D
PQA
S
L
QEIINR
---
PG
P
AL
IHV
R
ID
AE
--------
E
KVY
P
M
V
PP
GA
A
N
T
EM
fig|749540.3.peg.959
Escherichia coli MS 146-1 (19-559/562)
IV
HF
L
EQQ
G
I
KI
V
T
G
IP
G
GS
I
LP
V
Y
D
A
L
SQS
-
T
Q
I
R
HI
LA
RHEQ
G
A
GFI
A
Q
G
M
A
RTD
GK
P
A
V
--
C
MAC
SGPG
A
TN
L
V
T
AI
A
D
A
RL
D
SI
PLI
C
I
T
G
QVPASM
IG
--
T
D
A
FQE
V
D
TY
--------
GISIPIT
K
HNY
LV
RHI
E
E
LP
QV
M
SD
A
FRI
A
Q
S
-
GRPG
P
V
W
I
D
I
P
K
DV
QTAVFEIE
---
TQPAMAEKAAAP-
-
-AFSEE-S
I
RD
A
AAM
I
NA
A
KR
P
V
L
YL
G
G
G
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
TTMT
L
M
A
LG
ML
P
KA
HP
LSL
GM
L
GM
H
G
VRSTNYI
L
Q
E
AD
L
L
IV
L
G
A
RF
DD
R
AIGKTEQ
F
C
P
-
NA
KI
IH
V
DID
R
A
E
L
GKIKQPH
VAI
QA
D
VDDV
L
AQ
L
I
PL
V
EA----Q
P
R
A
--
-E
W
H
Q
LVADL
Q
REFPCPIP--KAC
D
----------------------------
P
-
LSHYGLINA
V
AA
----
CVDDNAII
T
T
DVG
QH
QM
W
T
A
QA
-
YPLNR
PR
QW
L
T
S
G
--------
GL
G
T
MG
F
GLP
A
AIGA
AL
A
N
P
DRK
V
L
C
FS
GDG
SLM
M
NIQ
E
MA
T
AS
E
NQ
L
D
V
K
I
I
LM
NN
EA
LG
L
V
H
-
QQQS
L
FYEQGVFAATYPGK
-----------
IN
F
MQ
I
A
A
G
F
G
LE
T
CD
L
NNEA
D
PQA
S
L
QEIINR
---
PG
P
AL
IHV
R
ID
AE
--------
E
KVY
P
M
V
PP
GA
A
N
T
EM
fig|749544.3.peg.1165
Escherichia coli MS 175-1 (19-559/562)
IV
HF
L
EQQ
G
I
KI
V
T
G
IP
G
GS
I
LP
V
Y
D
A
L
SQS
-
T
Q
I
R
HI
LA
RHEQ
G
A
GFI
A
Q
G
M
A
RTD
GK
P
A
V
--
C
MAC
SGPG
A
TN
L
V
T
AI
A
D
A
RL
D
SI
PLI
C
I
T
G
QVPASM
IG
--
T
D
A
FQE
V
D
TY
--------
GISIPIT
K
HNY
LV
RHI
E
E
LP
QV
M
SD
A
FRI
A
Q
S
-
GRPG
P
V
W
I
D
I
P
K
DV
QTAVFEIE
---
TQPAMAEKAAAP-
-
-AFSEE-S
I
RD
A
AAM
I
NA
A
KR
P
V
L
YL
G
G
G
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
TTMT
L
M
A
LG
ML
P
KA
HP
LSL
GM
L
GM
H
G
VRSTNYI
L
Q
E
AD
L
L
IV
L
G
A
RF
DD
R
AIGKTEQ
F
C
P
-
NA
KI
IH
V
DID
R
A
E
L
GKIKQPH
VAI
QA
D
VDDV
L
AQ
L
I
PL
V
EA----Q
P
R
A
--
-E
W
H
Q
LVADL
Q
REFPCPIP--KAC
D
----------------------------
P
-
LSHYGLINA
V
AA
----
CVDDNAII
T
T
DVG
QH
QM
W
T
A
QA
-
YPLNR
PR
QW
L
T
S
G
--------
GL
G
T
MG
F
GLP
A
AIGA
AL
A
N
P
DRK
V
L
C
FS
GDG
SLM
M
NIQ
E
MA
T
AS
E
NQ
L
D
V
K
I
I
LM
NN
EA
LG
L
V
H
-
QQQS
L
FYEQGVFAATYPGK
-----------
IN
F
MQ
I
A
A
G
F
G
LE
T
CD
L
NNEA
D
PQA
S
L
QEIINR
---
PG
P
AL
IHV
R
ID
AE
--------
E
KVY
P
M
V
PP
GA
A
N
T
EM
fig|749547.3.peg.4317
Escherichia coli MS 187-1 (19-559/562)
IV
HF
L
EQQ
G
I
KI
V
T
G
IP
G
GS
I
LP
V
Y
D
A
L
SQS
-
T
Q
I
R
HI
LA
RHEQ
G
A
GFI
A
Q
G
M
A
RTD
GK
P
A
V
--
C
MAC
SGPG
A
TN
L
V
T
AI
A
D
A
RL
D
SI
PLI
C
I
T
G
QVPASM
IG
--
T
D
A
FQE
V
D
TY
--------
GISIPIT
K
HNY
LV
RHI
E
E
LP
QV
M
SD
A
FRI
A
Q
S
-
GRPG
P
V
W
I
D
I
P
K
DV
QTAVFEIE
---
TQPAMAEKAAAP-
-
-AFSEE-S
I
RD
A
AAM
I
NA
A
KR
P
V
L
YL
G
G
G
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
TTMT
L
M
A
LG
ML
P
KA
HP
LSL
GM
L
GM
H
G
VRSTNYI
L
Q
E
AD
L
L
IV
L
G
A
RF
DD
R
AIGKTEQ
F
C
P
-
NA
KI
IH
V
DID
R
A
E
L
GKIKQPH
VAI
QA
D
VDDV
L
AQ
L
I
PL
V
EA----Q
P
R
A
--
-E
W
H
Q
LVADL
Q
REFPCPIP--KAC
D
----------------------------
P
-
LSHYGLINA
V
AA
----
CVDDNAII
T
T
DVG
QH
QM
W
T
A
QA
-
YPLNR
PR
QW
L
T
S
G
--------
GL
G
T
MG
F
GLP
A
AIGA
AL
A
N
P
DRK
V
L
C
FS
GDG
SLM
M
NIQ
E
MA
T
AS
E
NQ
L
D
V
K
I
I
LM
NN
EA
LG
L
V
H
-
QQQS
L
FYEQGVFAATYPGK
-----------
IN
F
MQ
I
A
A
G
F
G
LE
T
CD
L
NNEA
D
PQA
S
L
QEIINR
---
PG
P
AL
IHV
R
ID
AE
--------
E
KVY
P
M
V
PP
GA
A
N
T
EM
fig|749548.3.peg.4135
Escherichia coli MS 196-1 (19-559/562)
IV
HF
L
EQQ
G
I
KI
V
T
G
IP
G
GS
I
LP
V
Y
D
A
L
SQS
-
T
Q
I
R
HI
LA
RHEQ
G
A
GFI
A
Q
G
M
A
RTD
GK
P
A
V
--
C
MAC
SGPG
A
TN
L
V
T
AI
A
D
A
RL
D
SI
PLI
C
I
T
G
QVPASM
IG
--
T
D
A
FQE
V
D
TY
--------
GISIPIT
K
HNY
LV
RHI
E
E
LP
QV
M
SD
A
FRI
A
Q
S
-
GRPG
P
V
W
I
D
I
P
K
DV
QTAVFEIE
---
TQPAMAEKAAAP-
-
-AFSEE-S
I
RD
A
AAM
I
NA
A
KR
P
V
L
YL
G
G
G
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
TTMT
L
M
A
LG
ML
P
KA
HP
LSL
GM
L
GM
H
G
VRSTNYI
L
Q
E
AD
L
L
IV
L
G
A
RF
DD
R
AIGKTEQ
F
C
P
-
NA
KI
IH
V
DID
R
A
E
L
GKIKQPH
VAI
QA
D
VDDV
L
AQ
L
I
PL
V
EA----Q
P
R
A
--
-E
W
H
Q
LVADL
Q
REFPCPIP--KAC
D
----------------------------
P
-
LSHYGLINA
V
AA
----
CVDDNAII
T
T
DVG
QH
QM
W
T
A
QA
-
YPLNR
PR
QW
L
T
S
G
--------
GL
G
T
MG
F
GLP
A
AIGA
AL
A
N
P
DRK
V
L
C
FS
GDG
SLM
M
NIQ
E
MA
T
AS
E
NQ
L
D
V
K
I
I
LM
NN
EA
LG
L
V
H
-
QQQS
L
FYEQGVFAATYPGK
-----------
IN
F
MQ
I
A
A
G
F
G
LE
T
CD
L
NNEA
D
PQA
S
L
QEIINR
---
PG
P
AL
IHV
R
ID
AE
--------
E
KVY
P
M
V
PP
GA
A
N
T
EM
fig|316407.3.peg.3457
Escherichia coli W3110 (19-559/562)
IV
HF
L
EQQ
G
I
KI
V
T
G
IP
G
GS
I
LP
V
Y
D
A
L
SQS
-
T
Q
I
R
HI
LA
RHEQ
G
A
GFI
A
Q
G
M
A
RTD
GK
P
A
V
--
C
MAC
SGPG
A
TN
L
V
T
AI
A
D
A
RL
D
SI
PLI
C
I
T
G
QVPASM
IG
--
T
D
A
FQE
V
D
TY
--------
GISIPIT
K
HNY
LV
RHI
E
E
LP
QV
M
SD
A
FRI
A
Q
S
-
GRPG
P
V
W
I
D
I
P
K
DV
QTAVFEIE
---
TQPAMAEKAAAP-
-
-AFSEE-S
I
RD
A
AAM
I
NA
A
KR
P
V
L
YL
G
G
G
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
TTMT
L
M
A
LG
ML
P
KA
HP
LSL
GM
L
GM
H
G
VRSTNYI
L
Q
E
AD
L
L
IV
L
G
A
RF
DD
R
AIGKTEQ
F
C
P
-
NA
KI
IH
V
DID
R
A
E
L
GKIKQPH
VAI
QA
D
VDDV
L
AQ
L
I
PL
V
EA----Q
P
R
A
--
-E
W
H
Q
LVADL
Q
REFPCPIP--KAC
D
----------------------------
P
-
LSHYGLINA
V
AA
----
CVDDNAII
T
T
DVG
QH
QM
W
T
A
QA
-
YPLNR
PR
QW
L
T
S
G
--------
GL
G
T
MG
F
GLP
A
AIGA
AL
A
N
P
DRK
V
L
C
FS
GDG
SLM
M
NIQ
E
MA
T
AS
E
NQ
L
D
V
K
I
I
LM
NN
EA
LG
L
V
H
-
QQQS
L
FYEQGVFAATYPGK
-----------
IN
F
MQ
I
A
A
G
F
G
LE
T
CD
L
NNEA
D
PQA
S
L
QEIINR
---
PG
P
AL
IHV
R
ID
AE
--------
E
KVY
P
M
V
PP
GA
A
N
T
EM
fig|316385.5.peg.3806
Escherichia coli str. K-12 substr. DH10B (19-559/562)
IV
HF
L
EQQ
G
I
KI
V
T
G
IP
G
GS
I
LP
V
Y
D
A
L
SQS
-
T
Q
I
R
HI
LA
RHEQ
G
A
GFI
A
Q
G
M
A
RTD
GK
P
A
V
--
C
MAC
SGPG
A
TN
L
V
T
AI
A
D
A
RL
D
SI
PLI
C
I
T
G
QVPASM
IG
--
T
D
A
FQE
V
D
TY
--------
GISIPIT
K
HNY
LV
RHI
E
E
LP
QV
M
SD
A
FRI
A
Q
S
-
GRPG
P
V
W
I
D
I
P
K
DV
QTAVFEIE
---
TQPAMAEKAAAP-
-
-AFSEE-S
I
RD
A
AAM
I
NA
A
KR
P
V
L
YL
G
G
G
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
TTMT
L
M
A
LG
ML
P
KA
HP
LSL
GM
L
GM
H
G
VRSTNYI
L
Q
E
AD
L
L
IV
L
G
A
RF
DD
R
AIGKTEQ
F
C
P
-
NA
KI
IH
V
DID
R
A
E
L
GKIKQPH
VAI
QA
D
VDDV
L
AQ
L
I
PL
V
EA----Q
P
R
A
--
-E
W
H
Q
LVADL
Q
REFPCPIP--KAC
D
----------------------------
P
-
LSHYGLINA
V
AA
----
CVDDNAII
T
T
DVG
QH
QM
W
T
A
QA
-
YPLNR
PR
QW
L
T
S
G
--------
GL
G
T
MG
F
GLP
A
AIGA
AL
A
N
P
DRK
V
L
C
FS
GDG
SLM
M
NIQ
E
MA
T
AS
E
NQ
L
D
V
K
I
I
LM
NN
EA
LG
L
V
H
-
QQQS
L
FYEQGVFAATYPGK
-----------
IN
F
MQ
I
A
A
G
F
G
LE
T
CD
L
NNEA
D
PQA
S
L
QEIINR
---
PG
P
AL
IHV
R
ID
AE
--------
E
KVY
P
M
V
PP
GA
A
N
T
EM
fig|316385.7.peg.3892
Escherichia coli str. K-12 substr. DH10B (19-559/562)
IV
HF
L
EQQ
G
I
KI
V
T
G
IP
G
GS
I
LP
V
Y
D
A
L
SQS
-
T
Q
I
R
HI
LA
RHEQ
G
A
GFI
A
Q
G
M
A
RTD
GK
P
A
V
--
C
MAC
SGPG
A
TN
L
V
T
AI
A
D
A
RL
D
SI
PLI
C
I
T
G
QVPASM
IG
--
T
D
A
FQE
V
D
TY
--------
GISIPIT
K
HNY
LV
RHI
E
E
LP
QV
M
SD
A
FRI
A
Q
S
-
GRPG
P
V
W
I
D
I
P
K
DV
QTAVFEIE
---
TQPAMAEKAAAP-
-
-AFSEE-S
I
RD
A
AAM
I
NA
A
KR
P
V
L
YL
G
G
G
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
TTMT
L
M
A
LG
ML
P
KA
HP
LSL
GM
L
GM
H
G
VRSTNYI
L
Q
E
AD
L
L
IV
L
G
A
RF
DD
R
AIGKTEQ
F
C
P
-
NA
KI
IH
V
DID
R
A
E
L
GKIKQPH
VAI
QA
D
VDDV
L
AQ
L
I
PL
V
EA----Q
P
R
A
--
-E
W
H
Q
LVADL
Q
REFPCPIP--KAC
D
----------------------------
P
-
LSHYGLINA
V
AA
----
CVDDNAII
T
T
DVG
QH
QM
W
T
A
QA
-
YPLNR
PR
QW
L
T
S
G
--------
GL
G
T
MG
F
GLP
A
AIGA
AL
A
N
P
DRK
V
L
C
FS
GDG
SLM
M
NIQ
E
MA
T
AS
E
NQ
L
D
V
K
I
I
LM
NN
EA
LG
L
V
H
-
QQQS
L
FYEQGVFAATYPGK
-----------
IN
F
MQ
I
A
A
G
F
G
LE
T
CD
L
NNEA
D
PQA
S
L
QEIINR
---
PG
P
AL
IHV
R
ID
AE
--------
E
KVY
P
M
V
PP
GA
A
N
T
EM
fig|511145.12.peg.3793
Escherichia coli str. K-12 substr. MG1655 (19-559/562)
IV
HF
L
EQQ
G
I
KI
V
T
G
IP
G
GS
I
LP
V
Y
D
A
L
SQS
-
T
Q
I
R
HI
LA
RHEQ
G
A
GFI
A
Q
G
M
A
RTD
GK
P
A
V
--
C
MAC
SGPG
A
TN
L
V
T
AI
A
D
A
RL
D
SI
PLI
C
I
T
G
QVPASM
IG
--
T
D
A
FQE
V
D
TY
--------
GISIPIT
K
HNY
LV
RHI
E
E
LP
QV
M
SD
A
FRI
A
Q
S
-
GRPG
P
V
W
I
D
I
P
K
DV
QTAVFEIE
---
TQPAMAEKAAAP-
-
-AFSEE-S
I
RD
A
AAM
I
NA
A
KR
P
V
L
YL
G
G
G
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
TTMT
L
M
A
LG
ML
P
KA
HP
LSL
GM
L
GM
H
G
VRSTNYI
L
Q
E
AD
L
L
IV
L
G
A
RF
DD
R
AIGKTEQ
F
C
P
-
NA
KI
IH
V
DID
R
A
E
L
GKIKQPH
VAI
QA
D
VDDV
L
AQ
L
I
PL
V
EA----Q
P
R
A
--
-E
W
H
Q
LVADL
Q
REFPCPIP--KAC
D
----------------------------
P
-
LSHYGLINA
V
AA
----
CVDDNAII
T
T
DVG
QH
QM
W
T
A
QA
-
YPLNR
PR
QW
L
T
S
G
--------
GL
G
T
MG
F
GLP
A
AIGA
AL
A
N
P
DRK
V
L
C
FS
GDG
SLM
M
NIQ
E
MA
T
AS
E
NQ
L
D
V
K
I
I
LM
NN
EA
LG
L
V
H
-
QQQS
L
FYEQGVFAATYPGK
-----------
IN
F
MQ
I
A
A
G
F
G
LE
T
CD
L
NNEA
D
PQA
S
L
QEIINR
---
PG
P
AL
IHV
R
ID
AE
--------
E
KVY
P
M
V
PP
GA
A
N
T
EM
fig|511145.6.peg.3775
Escherichia coli str. K-12 substr. MG1655 (19-559/562)
IV
HF
L
EQQ
G
I
KI
V
T
G
IP
G
GS
I
LP
V
Y
D
A
L
SQS
-
T
Q
I
R
HI
LA
RHEQ
G
A
GFI
A
Q
G
M
A
RTD
GK
P
A
V
--
C
MAC
SGPG
A
TN
L
V
T
AI
A
D
A
RL
D
SI
PLI
C
I
T
G
QVPASM
IG
--
T
D
A
FQE
V
D
TY
--------
GISIPIT
K
HNY
LV
RHI
E
E
LP
QV
M
SD
A
FRI
A
Q
S
-
GRPG
P
V
W
I
D
I
P
K
DV
QTAVFEIE
---
TQPAMAEKAAAP-
-
-AFSEE-S
I
RD
A
AAM
I
NA
A
KR
P
V
L
YL
G
G
G
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
TTMT
L
M
A
LG
ML
P
KA
HP
LSL
GM
L
GM
H
G
VRSTNYI
L
Q
E
AD
L
L
IV
L
G
A
RF
DD
R
AIGKTEQ
F
C
P
-
NA
KI
IH
V
DID
R
A
E
L
GKIKQPH
VAI
QA
D
VDDV
L
AQ
L
I
PL
V
EA----Q
P
R
A
--
-E
W
H
Q
LVADL
Q
REFPCPIP--KAC
D
----------------------------
P
-
LSHYGLINA
V
AA
----
CVDDNAII
T
T
DVG
QH
QM
W
T
A
QA
-
YPLNR
PR
QW
L
T
S
G
--------
GL
G
T
MG
F
GLP
A
AIGA
AL
A
N
P
DRK
V
L
C
FS
GDG
SLM
M
NIQ
E
MA
T
AS
E
NQ
L
D
V
K
I
I
LM
NN
EA
LG
L
V
H
-
QQQS
L
FYEQGVFAATYPGK
-----------
IN
F
MQ
I
A
A
G
F
G
LE
T
CD
L
NNEA
D
PQA
S
L
QEIINR
---
PG
P
AL
IHV
R
ID
AE
--------
E
KVY
P
M
V
PP
GA
A
N
T
EM
fig|670888.3.peg.2545
Escherichia coli 1827-70 (19-559/562)
IV
HF
L
EQQ
G
I
KI
V
T
G
IP
G
GS
I
LP
V
Y
D
A
L
SQS
-
T
Q
I
R
HI
LA
RHEQ
G
A
GFI
A
Q
G
M
A
RTD
GK
P
A
V
--
C
MAC
SGPG
A
TN
L
V
T
AI
A
D
A
RL
D
SI
PLI
C
I
T
G
QVPASM
IG
--
T
D
A
FQE
V
D
TY
--------
GISIPIT
K
HNY
LV
RHI
E
E
LP
QV
M
SD
A
FRI
A
Q
S
-
GRPG
P
V
W
I
D
I
P
K
DV
QTAVFEIE
---
TQPAMAEKAAAP-
-
-AFSEE-S
I
RD
A
AAM
I
NA
A
KR
P
V
L
YL
G
G
G
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
TTMT
L
M
A
LG
ML
P
KA
HP
LSL
GM
L
GM
H
G
VRSTNYI
L
Q
E
AD
L
L
IV
L
G
A
RF
DD
R
AIGKTEQ
F
C
P
-
NA
KI
IH
V
DID
R
A
E
L
GKIKQPH
VAI
QA
D
VDDV
L
AQ
L
I
PL
V
EA----Q
P
R
A
--
-E
W
H
Q
LVADL
Q
REFPCPIP--KAC
D
----------------------------
P
-
LSHYGLINA
V
SA
----
CVDDNAII
T
T
DVG
QH
QM
W
T
A
QA
-
YPLNR
PR
QW
L
T
S
G
--------
GL
G
T
MG
F
GLP
A
AIGA
AL
A
N
P
DRK
V
L
C
FS
GDG
SLM
M
NIQ
E
MA
T
AS
E
NQ
L
D
V
K
I
I
LM
NN
EA
LG
L
V
H
-
QQQS
L
FYEQGVFAATYPGK
-----------
IN
F
MQ
I
A
A
G
F
G
LE
T
CD
L
NNEA
D
PQA
S
L
QEIINR
---
PG
P
AL
IHV
R
ID
AE
--------
E
KVY
P
M
V
PP
GA
A
N
T
EM
fig|340197.3.peg.475
Escherichia coli F11 (19-559/562)
IV
HF
L
EQQ
G
I
KI
V
T
G
IP
G
GS
I
LP
V
Y
D
A
L
SQS
-
T
Q
I
R
HI
LA
RHEQ
G
A
GFI
A
Q
G
M
A
RTD
GK
P
A
V
--
C
MAC
SGPG
A
TN
L
V
T
AI
A
D
A
RL
D
SI
PLI
C
I
T
G
QVSASM
IG
--
T
D
A
FQE
V
D
TY
--------
GISIPIT
K
HNY
LV
RHI
E
E
LP
QV
M
SD
A
FRI
A
Q
S
-
GRPG
P
V
W
I
D
I
P
K
DV
QTAVFEIE
---
TQPAMAEKAAAP-
-
-AFSEE-S
I
RD
A
AAM
I
NA
A
KH
P
V
L
YL
G
G
G
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
TTMT
L
M
A
LG
ML
P
KA
HP
LSL
GM
L
GM
H
G
VRSTNYI
L
Q
E
AD
L
L
IV
L
G
A
RF
DD
R
AIGKTEQ
F
C
P
-
NA
KI
IH
V
DID
R
A
E
L
GKIKQPH
VAI
QA
D
VDDV
L
AQ
L
I
PL
V
EA----Q
P
R
A
--
-E
W
H
Q
LVADL
Q
REFPCPIP--KAC
D
----------------------------
P
-
LSHYGLINA
V
AA
----
CVDDNAII
T
T
DVG
QH
QM
W
T
A
QA
-
YPLNR
PR
QW
L
T
S
G
--------
GL
G
T
MG
F
GLP
A
AIGA
AL
A
N
P
DRK
V
L
C
FS
GDG
SLM
M
NIQ
E
MA
T
AS
E
NQ
L
D
V
K
I
I
LM
NN
EA
LG
L
V
H
-
QQQS
L
FYKQGVFAATYPGK
-----------
IN
F
MQ
I
A
A
G
F
G
LE
T
CD
L
NNEA
D
PQA
AL
QEIINR
---
PG
P
AL
IHV
R
ID
AE
--------
E
KVY
P
M
V
PP
GA
A
N
T
EM
fig|340197.5.peg.491
Escherichia coli F11 (19-559/562)
IV
HF
L
EQQ
G
I
KI
V
T
G
IP
G
GS
I
LP
V
Y
D
A
L
SQS
-
T
Q
I
R
HI
LA
RHEQ
G
A
GFI
A
Q
G
M
A
RTD
GK
P
A
V
--
C
MAC
SGPG
A
TN
L
V
T
AI
A
D
A
RL
D
SI
PLI
C
I
T
G
QVSASM
IG
--
T
D
A
FQE
V
D
TY
--------
GISIPIT
K
HNY
LV
RHI
E
E
LP
QV
M
SD
A
FRI
A
Q
S
-
GRPG
P
V
W
I
D
I
P
K
DV
QTAVFEIE
---
TQPAMAEKAAAP-
-
-AFSEE-S
I
RD
A
AAM
I
NA
A
KH
P
V
L
YL
G
G
G
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
TTMT
L
M
A
LG
ML
P
KA
HP
LSL
GM
L
GM
H
G
VRSTNYI
L
Q
E
AD
L
L
IV
L
G
A
RF
DD
R
AIGKTEQ
F
C
P
-
NA
KI
IH
V
DID
R
A
E
L
GKIKQPH
VAI
QA
D
VDDV
L
AQ
L
I
PL
V
EA----Q
P
R
A
--
-E
W
H
Q
LVADL
Q
REFPCPIP--KAC
D
----------------------------
P
-
LSHYGLINA
V
AA
----
CVDDNAII
T
T
DVG
QH
QM
W
T
A
QA
-
YPLNR
PR
QW
L
T
S
G
--------
GL
G
T
MG
F
GLP
A
AIGA
AL
A
N
P
DRK
V
L
C
FS
GDG
SLM
M
NIQ
E
MA
T
AS
E
NQ
L
D
V
K
I
I
LM
NN
EA
LG
L
V
H
-
QQQS
L
FYKQGVFAATYPGK
-----------
IN
F
MQ
I
A
A
G
F
G
LE
T
CD
L
NNEA
D
PQA
AL
QEIINR
---
PG
P
AL
IHV
R
ID
AE
--------
E
KVY
P
M
V
PP
GA
A
N
T
EM
fig|749550.3.peg.3399
Escherichia coli MS 200-1 (19-559/562)
IV
HF
L
EQQ
G
I
KI
V
T
G
IP
G
GS
I
LP
V
Y
D
A
L
SQS
-
T
Q
I
R
HI
LA
RHEQ
G
A
GFI
A
Q
G
M
A
RTD
GK
P
A
V
--
C
MAC
SGPG
A
TN
L
V
T
AI
A
D
A
RL
D
SI
PLI
C
I
T
G
QVSASM
IG
--
T
D
A
FQE
V
D
TY
--------
GISIPIT
K
HNY
LV
RHI
E
E
LP
QV
M
SD
A
FRI
A
Q
S
-
GRPG
P
V
W
I
D
I
P
K
DV
QTAVFEIE
---
TQPAMAEKAAAP-
-
-AFSEE-S
I
RD
A
AAM
I
NA
A
KH
P
V
L
YL
G
G
G
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
TTMT
L
M
A
LG
ML
P
KA
HP
LSL
GM
L
GM
H
G
VRSTNYI
L
Q
E
AD
L
L
IV
L
G
A
RF
DD
R
AIGKTEQ
F
C
P
-
NA
KI
IH
V
DID
R
A
E
L
GKIKQPH
VAI
QA
D
VDDV
L
AQ
L
I
PL
V
EA----Q
P
R
A
--
-E
W
H
Q
LVADL
Q
REFPCPIP--KAC
D
----------------------------
P
-
LSHYGLINA
V
AA
----
CVDDNAII
T
T
DVG
QH
QM
W
T
A
QA
-
YPLNR
PR
QW
L
T
S
G
--------
GL
G
T
MG
F
GLP
A
AIGA
AL
A
N
P
DRK
V
L
C
FS
GDG
SLM
M
NIQ
E
MA
T
AS
E
NQ
L
D
V
K
I
I
LM
NN
EA
LG
L
V
H
-
QQQS
L
FYKQGVFAATYPGK
-----------
IN
F
MQ
I
A
A
G
F
G
LE
T
CD
L
NNEA
D
PQA
AL
QEIINR
---
PG
P
AL
IHV
R
ID
AE
--------
E
KVY
P
M
V
PP
GA
A
N
T
EM
fig|431946.3.peg.3666
Escherichia coli SE15 (19-559/562)
IV
HF
L
EQQ
G
I
KI
V
T
G
IP
G
GS
I
LP
V
Y
D
A
L
SQS
-
T
Q
I
R
HI
LA
RHEQ
G
A
GFI
A
Q
G
M
A
RTD
GK
P
A
V
--
C
MAC
SGPG
A
TN
L
V
T
AI
A
D
A
RL
D
SI
PLI
C
I
T
G
QVSASM
IG
--
T
D
A
FQE
V
D
TY
--------
GISIPIT
K
HNY
LV
RHI
E
E
LP
QV
M
SD
A
FSI
A
Q
S
-
GRPG
P
V
W
I
D
I
P
K
DV
QTAVFEIE
---
TQPAMAEKAAAP-
-
-AFSEE-S
I
RD
A
AAM
I
NA
A
KH
P
V
L
YL
G
G
G
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
TTMT
L
M
A
LG
ML
P
KA
HP
LSL
GM
L
GM
H
G
VRSTNYI
L
Q
E
AD
L
L
IV
L
G
A
RF
DD
R
AIGKTEQ
F
C
P
-
NA
KI
IH
V
DID
R
A
E
L
GKIKQPH
VAI
QA
D
VDDV
L
AQ
L
I
PL
V
EA----Q
P
R
A
--
-E
W
H
Q
LVADL
Q
REFPCPIP--KAC
D
----------------------------
P
-
LSHYGLINA
V
AA
----
CVDDNAII
T
T
DVG
QH
QM
W
T
A
QA
-
YPLNR
PR
QW
L
T
S
G
--------
GL
G
T
MG
F
GLP
A
AIGA
AL
A
N
P
DRK
V
L
C
FS
GDG
SLM
M
NIQ
E
MA
T
AS
E
NQ
L
D
V
K
I
I
LM
NN
EA
LG
L
V
H
-
QQQS
L
FYKQGVFAATYPGK
-----------
IN
F
MQ
I
A
A
G
F
G
LE
T
CD
L
NNEA
D
PQA
AL
QEIINR
---
PG
P
AL
IHV
R
ID
AE
--------
E
KVY
P
M
V
PP
GA
A
N
T
EM
fig|749537.3.peg.1264
Escherichia coli MS 115-1 (19-559/562)
IV
HF
L
EQQ
G
I
KI
V
T
G
IP
G
GS
I
LP
V
Y
D
A
L
SQS
-
T
Q
I
R
HI
LA
RHEQ
G
A
GFI
A
Q
G
M
A
RTD
GK
P
A
V
--
C
MAC
SGPG
A
TN
L
V
T
AI
A
D
A
RL
D
SI
PLI
C
I
T
G
QVPASM
IG
--
T
D
A
FQE
V
D
TY
--------
GISIPIT
K
HNY
LV
RHI
E
E
LP
QV
M
SD
A
FRI
A
Q
S
-
GRPG
P
V
W
I
D
I
P
K
DV
QTAVFEIE
---
AQPAVAEKAAAP-
-
-AFSEE-S
I
RD
A
AAM
I
NA
A
KR
P
V
L
YL
G
G
G
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
TTMT
L
M
A
LG
ML
P
KA
HP
LSL
GM
L
GM
H
G
VRSTNYI
L
Q
E
AD
L
L
IV
L
G
A
RF
DD
R
AIGKTEQ
F
C
P
-
NA
KI
IH
V
DID
R
A
E
L
GKIKQPH
VAI
QA
D
VDDV
L
AQ
L
I
PL
V
EA----Q
P
R
A
--
-E
W
H
Q
LVVDL
Q
REFPCPIP--KAC
D
----------------------------
P
-
LSHYGLINA
V
AA
----
CVDDNAII
T
T
DVG
QH
QM
W
T
A
QA
-
YPLNR
PR
QW
L
T
S
G
--------
GL
G
T
MG
F
GLP
A
AIGA
AL
A
N
P
DRK
V
L
C
FS
GDG
SLM
M
NIQ
E
MA
T
AS
E
NQ
L
D
V
K
I
I
LM
NN
EA
LG
L
V
H
-
QQQS
L
FYEQGVFAATYPGK
-----------
IN
F
MQ
I
A
A
G
F
G
LE
T
CD
L
NNEA
D
PQA
AL
QEIINR
---
PG
P
AL
IHV
R
ID
AE
--------
E
KVY
P
M
V
PP
GA
A
N
T
EM
fig|405955.13.peg.4130
Escherichia coli APEC O1 (19-559/562)
IV
HF
L
EQQ
G
I
KI
V
T
G
IP
G
GS
I
LP
V
Y
D
A
L
SQS
-
T
Q
I
R
HI
LA
RHEQ
G
A
GFI
A
Q
G
M
A
RTD
GK
P
A
V
--
C
MAC
SGPG
A
TN
L
V
T
AI
A
D
A
RL
D
SI
PLI
C
I
T
G
QVPASM
IG
--
T
D
A
FQE
V
D
TY
--------
GISIPIT
K
HNY
LV
RHI
E
E
LP
QV
M
SD
A
FRI
A
Q
S
-
GRPG
P
V
W
I
D
I
P
K
DV
QTAVFEIE
---
TQPAMAEKAAAP-
-
-AFSEE-S
I
RD
A
AAM
I
NA
A
KH
P
V
L
YL
G
G
G
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
TTMT
L
M
A
LG
ML
P
KA
HP
LSL
GM
L
GM
H
G
VRSTNYI
L
Q
E
AD
L
L
IV
L
G
A
RF
DD
R
AIGKTEQ
F
C
P
-
NA
KI
IH
V
DID
R
A
E
L
GKIKQPH
VAI
QA
D
VDDV
L
AQ
L
I
PL
V
EA----Q
P
R
A
--
-E
W
H
Q
LVADL
Q
REFPCPIP--KAC
D
----------------------------
P
-
LSHYGLINA
V
AA
----
CVDDNAII
T
T
DVG
QH
QM
W
T
A
QA
-
YPLNR
PR
QW
L
T
S
G
--------
GL
G
T
MG
F
GLP
A
AIGA
AL
A
N
P
DRK
V
L
C
FS
GDG
SLM
M
NIQ
E
MA
T
AS
E
NQ
L
D
V
K
I
I
LM
NN
EA
LG
L
V
H
-
QQQS
L
FYKQGVFAATYPGK
-----------
IN
F
MQ
I
A
A
G
F
G
LE
T
CD
L
NNEA
D
PQA
AL
QEIINR
---
PG
P
AL
IHV
R
ID
AE
--------
E
KVY
P
M
V
PP
GA
A
N
T
EM
fig|405955.9.peg.3457
Escherichia coli APEC O1 (19-559/562)
IV
HF
L
EQQ
G
I
KI
V
T
G
IP
G
GS
I
LP
V
Y
D
A
L
SQS
-
T
Q
I
R
HI
LA
RHEQ
G
A
GFI
A
Q
G
M
A
RTD
GK
P
A
V
--
C
MAC
SGPG
A
TN
L
V
T
AI
A
D
A
RL
D
SI
PLI
C
I
T
G
QVPASM
IG
--
T
D
A
FQE
V
D
TY
--------
GISIPIT
K
HNY
LV
RHI
E
E
LP
QV
M
SD
A
FRI
A
Q
S
-
GRPG
P
V
W
I
D
I
P
K
DV
QTAVFEIE
---
TQPAMAEKAAAP-
-
-AFSEE-S
I
RD
A
AAM
I
NA
A
KH
P
V
L
YL
G
G
G
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
TTMT
L
M
A
LG
ML
P
KA
HP
LSL
GM
L
GM
H
G
VRSTNYI
L
Q
E
AD
L
L
IV
L
G
A
RF
DD
R
AIGKTEQ
F
C
P
-
NA
KI
IH
V
DID
R
A
E
L
GKIKQPH
VAI
QA
D
VDDV
L
AQ
L
I
PL
V
EA----Q
P
R
A
--
-E
W
H
Q
LVADL
Q
REFPCPIP--KAC
D
----------------------------
P
-
LSHYGLINA
V
AA
----
CVDDNAII
T
T
DVG
QH
QM
W
T
A
QA
-
YPLNR
PR
QW
L
T
S
G
--------
GL
G
T
MG
F
GLP
A
AIGA
AL
A
N
P
DRK
V
L
C
FS
GDG
SLM
M
NIQ
E
MA
T
AS
E
NQ
L
D
V
K
I
I
LM
NN
EA
LG
L
V
H
-
QQQS
L
FYKQGVFAATYPGK
-----------
IN
F
MQ
I
A
A
G
F
G
LE
T
CD
L
NNEA
D
PQA
AL
QEIINR
---
PG
P
AL
IHV
R
ID
AE
--------
E
KVY
P
M
V
PP
GA
A
N
T
EM
fig|714962.3.peg.4164
Escherichia coli IHE3034 (19-559/562)
IV
HF
L
EQQ
G
I
KI
V
T
G
IP
G
GS
I
LP
V
Y
D
A
L
SQS
-
T
Q
I
R
HI
LA
RHEQ
G
A
GFI
A
Q
G
M
A
RTD
GK
P
A
V
--
C
MAC
SGPG
A
TN
L
V
T
AI
A
D
A
RL
D
SI
PLI
C
I
T
G
QVPASM
IG
--
T
D
A
FQE
V
D
TY
--------
GISIPIT
K
HNY
LV
RHI
E
E
LP
QV
M
SD
A
FRI
A
Q
S
-
GRPG
P
V
W
I
D
I
P
K
DV
QTAVFEIE
---
TQPAMAEKAAAP-
-
-AFSEE-S
I
RD
A
AAM
I
NA
A
KH
P
V
L
YL
G
G
G
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
TTMT
L
M
A
LG
ML
P
KA
HP
LSL
GM
L
GM
H
G
VRSTNYI
L
Q
E
AD
L
L
IV
L
G
A
RF
DD
R
AIGKTEQ
F
C
P
-
NA
KI
IH
V
DID
R
A
E
L
GKIKQPH
VAI
QA
D
VDDV
L
AQ
L
I
PL
V
EA----Q
P
R
A
--
-E
W
H
Q
LVADL
Q
REFPCPIP--KAC
D
----------------------------
P
-
LSHYGLINA
V
AA
----
CVDDNAII
T
T
DVG
QH
QM
W
T
A
QA
-
YPLNR
PR
QW
L
T
S
G
--------
GL
G
T
MG
F
GLP
A
AIGA
AL
A
N
P
DRK
V
L
C
FS
GDG
SLM
M
NIQ
E
MA
T
AS
E
NQ
L
D
V
K
I
I
LM
NN
EA
LG
L
V
H
-
QQQS
L
FYKQGVFAATYPGK
-----------
IN
F
MQ
I
A
A
G
F
G
LE
T
CD
L
NNEA
D
PQA
AL
QEIINR
---
PG
P
AL
IHV
R
ID
AE
--------
E
KVY
P
M
V
PP
GA
A
N
T
EM
fig|585035.6.peg.4025
Escherichia coli S88 (19-559/562)
IV
HF
L
EQQ
G
I
KI
V
T
G
IP
G
GS
I
LP
V
Y
D
A
L
SQS
-
T
Q
I
R
HI
LA
RHEQ
G
A
GFI
A
Q
G
M
A
RTD
GK
P
A
V
--
C
MAC
SGPG
A
TN
L
V
T
AI
A
D
A
RL
D
SI
PLI
C
I
T
G
QVPASM
IG
--
T
D
A
FQE
V
D
TY
--------
GISIPIT
K
HNY
LV
RHI
E
E
LP
QV
M
SD
A
FRI
A
Q
S
-
GRPG
P
V
W
I
D
I
P
K
DV
QTAVFEIE
---
TQPAMAEKAAAP-
-
-AFSEE-S
I
RD
A
AAM
I
NA
A
KH
P
V
L
YL
G
G
G
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
TTMT
L
M
A
LG
ML
P
KA
HP
LSL
GM
L
GM
H
G
VRSTNYI
L
Q
E
AD
L
L
IV
L
G
A
RF
DD
R
AIGKTEQ
F
C
P
-
NA
KI
IH
V
DID
R
A
E
L
GKIKQPH
VAI
QA
D
VDDV
L
AQ
L
I
PL
V
EA----Q
P
R
A
--
-E
W
H
Q
LVADL
Q
REFPCPIP--KAC
D
----------------------------
P
-
LSHYGLINA
V
AA
----
CVDDNAII
T
T
DVG
QH
QM
W
T
A
QA
-
YPLNR
PR
QW
L
T
S
G
--------
GL
G
T
MG
F
GLP
A
AIGA
AL
A
N
P
DRK
V
L
C
FS
GDG
SLM
M
NIQ
E
MA
T
AS
E
NQ
L
D
V
K
I
I
LM
NN
EA
LG
L
V
H
-
QQQS
L
FYKQGVFAATYPGK
-----------
IN
F
MQ
I
A
A
G
F
G
LE
T
CD
L
NNEA
D
PQA
AL
QEIINR
---
PG
P
AL
IHV
R
ID
AE
--------
E
KVY
P
M
V
PP
GA
A
N
T
EM
fig|869729.3.peg.3980
Escherichia coli UM146 (19-559/562)
IV
HF
L
EQQ
G
I
KI
V
T
G
IP
G
GS
I
LP
V
Y
D
A
L
SQS
-
T
Q
I
R
HI
LA
RHEQ
G
A
GFI
A
Q
G
M
A
RTD
GK
P
A
V
--
C
MAC
SGPG
A
TN
L
V
T
AI
A
D
A
RL
D
SI
PLI
C
I
T
G
QVPASM
IG
--
T
D
A
FQE
V
D
TY
--------
GISIPIT
K
HNY
LV
RHI
E
E
LP
QV
M
SD
A
FRI
A
Q
S
-
GRPG
P
V
W
I
D
I
P
K
DV
QTAVFEIE
---
TQPAMAEKAAAP-
-
-AFSEE-S
I
RD
A
AAM
I
NA
A
KH
P
V
L
YL
G
G
G
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
TTMT
L
M
A
LG
ML
P
KA
HP
LSL
GM
L
GM
H
G
VRSTNYI
L
Q
E
AD
L
L
IV
L
G
A
RF
DD
R
AIGKTEQ
F
C
P
-
NA
KI
IH
V
DID
R
A
E
L
GKIKQPH
VAI
QA
D
VDDV
L
AQ
L
I
PL
V
EA----Q
P
R
A
--
-E
W
H
Q
LVADL
Q
REFPCPIP--KAC
D
----------------------------
P
-
LSHYGLINA
V
AA
----
CVDDNAII
T
T
DVG
QH
QM
W
T
A
QA
-
YPLNR
PR
QW
L
T
S
G
--------
GL
G
T
MG
F
GLP
A
AIGA
AL
A
N
P
DRK
V
L
C
FS
GDG
SLM
M
NIQ
E
MA
T
AS
E
NQ
L
D
V
K
I
I
LM
NN
EA
LG
L
V
H
-
QQQS
L
FYKQGVFAATYPGK
-----------
IN
F
MQ
I
A
A
G
F
G
LE
T
CD
L
NNEA
D
PQA
AL
QEIINR
---
PG
P
AL
IHV
R
ID
AE
--------
E
KVY
P
M
V
PP
GA
A
N
T
EM
fig|364106.7.peg.4131
Escherichia coli UTI89 (19-559/562)
IV
HF
L
EQQ
G
I
KI
V
T
G
IP
G
GS
I
LP
V
Y
D
A
L
SQS
-
T
Q
I
R
HI
LA
RHEQ
G
A
GFI
A
Q
G
M
A
RTD
GK
P
A
V
--
C
MAC
SGPG
A
TN
L
V
T
AI
A
D
A
RL
D
SI
PLI
C
I
T
G
QVPASM
IG
--
T
D
A
FQE
V
D
TY
--------
GISIPIT
K
HNY
LV
RHI
E
E
LP
QV
M
SD
A
FRI
A
Q
S
-
GRPG
P
V
W
I
D
I
P
K
DV
QTAVFEIE
---
TQPAMAEKAAAP-
-
-AFSEE-S
I
RD
A
AAM
I
NA
A
KH
P
V
L
YL
G
G
G
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
TTMT
L
M
A
LG
ML
P
KA
HP
LSL
GM
L
GM
H
G
VRSTNYI
L
Q
E
AD
L
L
IV
L
G
A
RF
DD
R
AIGKTEQ
F
C
P
-
NA
KI
IH
V
DID
R
A
E
L
GKIKQPH
VAI
QA
D
VDDV
L
AQ
L
I
PL
V
EA----Q
P
R
A
--
-E
W
H
Q
LVADL
Q
REFPCPIP--KAC
D
----------------------------
P
-
LSHYGLINA
V
AA
----
CVDDNAII
T
T
DVG
QH
QM
W
T
A
QA
-
YPLNR
PR
QW
L
T
S
G
--------
GL
G
T
MG
F
GLP
A
AIGA
AL
A
N
P
DRK
V
L
C
FS
GDG
SLM
M
NIQ
E
MA
T
AS
E
NQ
L
D
V
K
I
I
LM
NN
EA
LG
L
V
H
-
QQQS
L
FYKQGVFAATYPGK
-----------
IN
F
MQ
I
A
A
G
F
G
LE
T
CD
L
NNEA
D
PQA
AL
QEIINR
---
PG
P
AL
IHV
R
ID
AE
--------
E
KVY
P
M
V
PP
GA
A
N
T
EM
fig|364106.8.peg.4133
Escherichia coli UTI89 (19-559/562)
IV
HF
L
EQQ
G
I
KI
V
T
G
IP
G
GS
I
LP
V
Y
D
A
L
SQS
-
T
Q
I
R
HI
LA
RHEQ
G
A
GFI
A
Q
G
M
A
RTD
GK
P
A
V
--
C
MAC
SGPG
A
TN
L
V
T
AI
A
D
A
RL
D
SI
PLI
C
I
T
G
QVPASM
IG
--
T
D
A
FQE
V
D
TY
--------
GISIPIT
K
HNY
LV
RHI
E
E
LP
QV
M
SD
A
FRI
A
Q
S
-
GRPG
P
V
W
I
D
I
P
K
DV
QTAVFEIE
---
TQPAMAEKAAAP-
-
-AFSEE-S
I
RD
A
AAM
I
NA
A
KH
P
V
L
YL
G
G
G
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
TTMT
L
M
A
LG
ML
P
KA
HP
LSL
GM
L
GM
H
G
VRSTNYI
L
Q
E
AD
L
L
IV
L
G
A
RF
DD
R
AIGKTEQ
F
C
P
-
NA
KI
IH
V
DID
R
A
E
L
GKIKQPH
VAI
QA
D
VDDV
L
AQ
L
I
PL
V
EA----Q
P
R
A
--
-E
W
H
Q
LVADL
Q
REFPCPIP--KAC
D
----------------------------
P
-
LSHYGLINA
V
AA
----
CVDDNAII
T
T
DVG
QH
QM
W
T
A
QA
-
YPLNR
PR
QW
L
T
S
G
--------
GL
G
T
MG
F
GLP
A
AIGA
AL
A
N
P
DRK
V
L
C
FS
GDG
SLM
M
NIQ
E
MA
T
AS
E
NQ
L
D
V
K
I
I
LM
NN
EA
LG
L
V
H
-
QQQS
L
FYKQGVFAATYPGK
-----------
IN
F
MQ
I
A
A
G
F
G
LE
T
CD
L
NNEA
D
PQA
AL
QEIINR
---
PG
P
AL
IHV
R
ID
AE
--------
E
KVY
P
M
V
PP
GA
A
N
T
EM
fig|656408.3.peg.4127
Escherichia coli H591 (19-559/562)
IV
HF
L
EQQ
G
I
KI
V
T
G
IP
G
GS
I
LP
V
Y
D
A
L
SQS
-
T
Q
I
R
HI
LA
RHEQ
G
A
GFI
A
Q
G
M
A
RTD
GK
P
A
V
--
C
MAC
SGPG
A
TN
L
V
T
AI
A
D
A
RL
D
SI
PLI
C
I
T
G
QVPASM
IG
--
T
D
A
FQE
V
D
TY
--------
GISIPIT
K
HNY
LV
RHI
E
E
LP
QV
M
SD
A
FRI
A
Q
S
-
GRPG
P
V
W
I
D
I
P
K
DV
QTAVFEIE
---
TQPAMAEKAAAP-
-
-AFSEE-S
I
RD
A
AAM
I
NA
A
KR
P
V
L
YL
G
G
G
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
TTMT
L
M
A
LG
ML
P
KA
HP
LSL
GM
L
GM
H
G
VRSTNYI
L
Q
E
AD
L
L
IV
L
G
A
RF
DD
R
AIGKTEQ
F
C
P
-
NA
KI
IH
V
DID
R
A
E
L
GKIKQPH
VAI
QA
D
VDDV
L
AQ
L
I
PQ
V
EA----Q
P
R
A
--
-E
W
H
Q
LVADL
Q
REFPCPIP--KAC
D
----------------------------
P
-
LSHYGLINA
V
AA
----
CVDDNAII
T
T
DVG
QH
QM
W
T
A
QA
-
YPLNR
PR
QW
L
T
S
G
--------
GL
G
T
MG
F
GLP
A
AIGA
AL
A
N
P
DRK
V
L
C
FS
GDG
SLM
M
NIQ
E
MA
T
AS
E
NQ
L
D
V
K
I
I
LM
NN
EA
LG
L
V
H
-
QQQS
L
FYEQGVFAATYPGK
-----------
IN
F
MQ
I
A
A
G
F
G
LE
T
CD
L
NNEA
D
PQA
AL
QEIINR
---
PG
P
AL
IHV
R
ID
AE
--------
E
KVY
P
M
V
SP
GA
A
N
T
EM
fig|439855.10.peg.4178
Escherichia coli SMS-3-5 (19-559/562)
IV
HF
L
EQQ
G
I
KI
V
T
G
IP
G
GS
I
LP
V
Y
D
A
L
SQS
-
T
Q
I
R
HI
LA
RHEQ
G
A
GFI
A
Q
G
M
A
RTD
GK
P
A
V
--
C
MAC
SGPG
A
TN
L
V
T
AI
A
D
A
RL
D
SI
PLI
C
I
T
G
QVPASM
IG
--
T
D
A
FQE
V
D
TY
--------
GISIPIT
K
HNY
LV
RHI
E
E
LP
QV
M
SD
A
FRI
A
Q
S
-
GRPG
P
V
W
I
D
I
P
K
DV
QTAVFEIE
---
AQAAMAEKAAAP-
-
-AFSEE-S
I
RD
A
AAM
I
NA
A
KR
P
V
L
YL
G
G
G
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
TTMT
L
M
A
LG
ML
P
KA
HP
LSL
GM
L
GM
H
G
VRSTNYI
L
Q
E
AD
L
L
IV
L
G
A
RF
DD
R
AIGKTEQ
F
C
P
-
NA
KI
IH
V
DID
R
A
E
L
GKIKQPH
VAI
QA
D
VDDV
L
AQ
L
I
PQ
V
EA----Q
P
R
A
--
-E
W
H
Q
LVADL
Q
REFPYPIP--KAC
D
----------------------------
P
-
LTHYGLINA
V
AA
----
CVDDNAII
T
T
DVG
QH
QM
W
T
A
QA
-
YPLNR
PR
QW
L
T
S
G
--------
GL
G
T
MG
F
GLP
A
AIGA
AL
A
N
P
DRK
V
L
C
FS
GDG
SLM
M
NIQ
E
MA
T
AS
E
NQ
L
D
V
K
I
I
LM
NN
EA
LG
L
V
H
-
QQQS
L
FYKQGVFAATYPGK
-----------
IN
F
MQ
I
A
A
G
F
G
LE
T
CD
L
NNET
D
PQA
AL
QEIINR
---
PG
P
AL
IHV
R
ID
AE
--------
E
KVY
P
M
V
PP
GA
A
N
T
EM
fig|1040638.4.peg.1555
Escherichia coli O104:H4 str. LB226692 (19-559/562)
IV
HF
L
EQQ
G
I
KI
V
T
G
IP
G
GS
I
LP
V
Y
D
A
L
SQS
-
T
Q
I
R
HI
LA
RHEQ
G
A
GFI
A
Q
G
M
A
RTD
GK
P
A
V
--
C
MAC
SGPG
A
TN
L
V
T
AI
A
D
A
RL
D
SI
PLI
C
I
T
G
QVPASM
IG
--
T
D
A
FQE
V
D
TY
--------
GISIPIT
K
HNY
LV
RHI
E
E
LP
QV
M
SD
A
FRI
A
Q
S
-
GRPG
P
V
W
I
D
I
P
K
DV
QTAVFEIE
---
TQPAMAEKAAAP-
-
-AFSEE-S
I
RD
A
AAM
I
NA
A
KR
P
V
L
YL
G
G
G
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
TTMT
L
M
A
LG
ML
P
KA
HP
LSL
GM
L
GM
H
G
VRSTNYI
L
Q
E
AD
L
L
IV
L
G
A
RF
DD
R
AIGKTEQ
F
C
P
-
NA
KI
IH
V
DID
R
A
E
L
GKIKQPH
VAI
QA
D
VDDV
L
AQ
L
I
PQ
V
EA----Q
P
R
A
--
-E
W
H
Q
LVADL
Q
REFPCPIP--KAC
D
----------------------------
P
-
LSHYGLINA
V
AA
----
CVDDNAII
T
T
DVG
QH
QM
W
T
A
QA
-
YPLNR
PR
QW
L
T
S
G
--------
GL
G
T
MG
F
GLP
A
AIGA
AL
A
N
P
DRK
V
L
C
FS
GDG
SLM
M
NIQ
E
MA
T
AS
E
NQ
L
D
V
K
I
I
LM
NN
EA
LG
L
V
H
-
QQQS
L
FYEQGVFAATYPGK
-----------
IN
F
MQ
I
A
A
G
F
G
LE
T
CD
L
NNEA
D
PQA
AL
QEIINR
---
PG
P
AL
IHV
R
ID
AE
--------
E
KVY
P
M
V
PP
GA
A
N
T
EM
fig|6666666.5357.peg.677
Escherichia coli TY-2482 (19-559/562)
IV
HF
L
EQQ
G
I
KI
V
T
G
IP
G
GS
I
LP
V
Y
D
A
L
SQS
-
T
Q
I
R
HI
LA
RHEQ
G
A
GFI
A
Q
G
M
A
RTD
GK
P
A
V
--
C
MAC
SGPG
A
TN
L
V
T
AI
A
D
A
RL
D
SI
PLI
C
I
T
G
QVPASM
IG
--
T
D
A
FQE
V
D
TY
--------
GISIPIT
K
HNY
LV
RHI
E
E
LP
QV
M
SD
A
FRI
A
Q
S
-
GRPG
P
V
W
I
D
I
P
K
DV
QTAVFEIE
---
TQPAMAEKAAAP-
-
-AFSEE-S
I
RD
A
AAM
I
NA
A
KR
P
V
L
YL
G
G
G
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
TTMT
L
M
A
LG
ML
P
KA
HP
LSL
GM
L
GM
H
G
VRSTNYI
L
Q
E
AD
L
L
IV
L
G
A
RF
DD
R
AIGKTEQ
F
C
P
-
NA
KI
IH
V
DID
R
A
E
L
GKIKQPH
VAI
QA
D
VDDV
L
AQ
L
I
PQ
V
EA----Q
P
R
A
--
-E
W
H
Q
LVADL
Q
REFPCPIP--KAC
D
----------------------------
P
-
LSHYGLINA
V
AA
----
CVDDNAII
T
T
DVG
QH
QM
W
T
A
QA
-
YPLNR
PR
QW
L
T
S
G
--------
GL
G
T
MG
F
GLP
A
AIGA
AL
A
N
P
DRK
V
L
C
FS
GDG
SLM
M
NIQ
E
MA
T
AS
E
NQ
L
D
V
K
I
I
LM
NN
EA
LG
L
V
H
-
QQQS
L
FYEQGVFAATYPGK
-----------
IN
F
MQ
I
A
A
G
F
G
LE
T
CD
L
NNEA
D
PQA
AL
QEIINR
---
PG
P
AL
IHV
R
ID
AE
--------
E
KVY
P
M
V
PP
GA
A
N
T
EM
fig|585055.6.peg.4171
Escherichia coli 55989 (19-559/562)
IV
HF
L
EQQ
G
I
KI
V
T
G
IP
G
GS
I
LP
V
Y
D
A
L
SQS
-
T
Q
I
R
HI
LA
RHEQ
G
A
GFI
A
Q
G
M
A
RTD
GK
P
A
V
--
C
MAC
SGPG
A
TN
L
V
T
AI
A
D
A
RL
D
SI
PLI
C
I
T
G
QVPASM
IG
--
T
D
A
FQE
V
D
TY
--------
GISIPIT
K
HNY
LV
RHI
E
E
LP
QV
M
SD
A
FRI
A
Q
S
-
GRPG
P
V
W
I
D
I
P
K
DV
QTAVFEIE
---
TQPAMAEKAAAP-
-
-AFSEE-S
I
RD
A
AAM
I
NA
A
KR
P
V
L
YL
G
G
G
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
TTMT
L
M
A
LG
ML
P
KA
HP
LSL
GM
L
GM
H
G
VRSTNYI
L
Q
E
AD
L
L
IV
L
G
A
RF
DD
R
AIGKTEQ
F
C
P
-
NA
KI
IH
V
DID
R
A
E
L
GKIKQPH
VAI
QA
D
VDDV
L
AQ
L
I
PQ
V
EA----Q
P
R
A
--
-E
W
H
Q
LVADL
Q
REFPCPIP--KAC
D
----------------------------
P
-
LSHYGLINA
V
AA
----
CVDDNAII
T
T
DVG
QH
QM
W
T
A
QA
-
YPLNR
PR
QW
L
T
S
G
--------
GL
G
T
MG
F
GLP
A
AIGA
AL
A
N
P
DRK
V
L
C
FS
GDG
SLM
M
NIQ
E
MA
T
AS
E
NQ
L
D
V
K
I
I
LM
NN
EA
LG
L
V
H
-
QQQS
L
FYEQGVFAATYPGK
-----------
IN
F
MQ
I
A
A
G
F
G
LE
T
CD
L
NNEA
D
PQA
AL
QEIINR
---
PG
P
AL
IHV
R
ID
AE
--------
E
KVY
P
M
V
PP
GA
A
N
T
EM
fig|585055.8.peg.4174
Escherichia coli 55989 (19-559/562)
IV
HF
L
EQQ
G
I
KI
V
T
G
IP
G
GS
I
LP
V
Y
D
A
L
SQS
-
T
Q
I
R
HI
LA
RHEQ
G
A
GFI
A
Q
G
M
A
RTD
GK
P
A
V
--
C
MAC
SGPG
A
TN
L
V
T
AI
A
D
A
RL
D
SI
PLI
C
I
T
G
QVPASM
IG
--
T
D
A
FQE
V
D
TY
--------
GISIPIT
K
HNY
LV
RHI
E
E
LP
QV
M
SD
A
FRI
A
Q
S
-
GRPG
P
V
W
I
D
I
P
K
DV
QTAVFEIE
---
TQPAMAEKAAAP-
-
-AFSEE-S
I
RD
A
AAM
I
NA
A
KR
P
V
L
YL
G
G
G
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
TTMT
L
M
A
LG
ML
P
KA
HP
LSL
GM
L
GM
H
G
VRSTNYI
L
Q
E
AD
L
L
IV
L
G
A
RF
DD
R
AIGKTEQ
F
C
P
-
NA
KI
IH
V
DID
R
A
E
L
GKIKQPH
VAI
QA
D
VDDV
L
AQ
L
I
PQ
V
EA----Q
P
R
A
--
-E
W
H
Q
LVADL
Q
REFPCPIP--KAC
D
----------------------------
P
-
LSHYGLINA
V
AA
----
CVDDNAII
T
T
DVG
QH
QM
W
T
A
QA
-
YPLNR
PR
QW
L
T
S
G
--------
GL
G
T
MG
F
GLP
A
AIGA
AL
A
N
P
DRK
V
L
C
FS
GDG
SLM
M
NIQ
E
MA
T
AS
E
NQ
L
D
V
K
I
I
LM
NN
EA
LG
L
V
H
-
QQQS
L
FYEQGVFAATYPGK
-----------
IN
F
MQ
I
A
A
G
F
G
LE
T
CD
L
NNEA
D
PQA
AL
QEIINR
---
PG
P
AL
IHV
R
ID
AE
--------
E
KVY
P
M
V
PP
GA
A
N
T
EM
fig|550672.3.peg.3741
Escherichia coli B088 (19-559/562)
IV
HF
L
EQQ
G
I
KI
V
T
G
IP
G
GS
I
LP
V
Y
D
A
L
SQS
-
T
Q
I
R
HI
LA
RHEQ
G
A
GFI
A
Q
G
M
A
RTD
GK
P
A
V
--
C
MAC
SGPG
A
TN
L
V
T
AI
A
D
A
RL
D
SI
PLI
C
I
T
G
QVPASM
IG
--
T
D
A
FQE
V
D
TY
--------
GISIPIT
K
HNY
LV
RHI
E
E
LP
QV
M
SD
A
FRI
A
Q
S
-
GRPG
P
V
W
I
D
I
P
K
DV
QTAVFEIE
---
TQPAMAEKAAAP-
-
-AFSEE-S
I
RD
A
AAM
I
NA
A
KR
P
V
L
YL
G
G
G
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
TTMT
L
M
A
LG
ML
P
KA
HP
LSL
GM
L
GM
H
G
VRSTNYI
L
Q
E
AD
L
L
IV
L
G
A
RF
DD
R
AIGKTEQ
F
C
P
-
NA
KI
IH
V
DID
R
A
E
L
GKIKQPH
VAI
QA
D
VDDV
L
AQ
L
I
PQ
V
EA----Q
P
R
A
--
-E
W
H
Q
LVADL
Q
REFPCPIP--KAC
D
----------------------------
P
-
LSHYGLINA
V
AA
----
CVDDNAII
T
T
DVG
QH
QM
W
T
A
QA
-
YPLNR
PR
QW
L
T
S
G
--------
GL
G
T
MG
F
GLP
A
AIGA
AL
A
N
P
DRK
V
L
C
FS
GDG
SLM
M
NIQ
E
MA
T
AS
E
NQ
L
D
V
K
I
I
LM
NN
EA
LG
L
V
H
-
QQQS
L
FYEQGVFAATYPGK
-----------
IN
F
MQ
I
A
A
G
F
G
LE
T
CD
L
NNEA
D
PQA
AL
QEIINR
---
PG
P
AL
IHV
R
ID
AE
--------
E
KVY
P
M
V
PP
GA
A
N
T
EM
fig|344601.3.peg.2441
Escherichia coli B171 (19-559/562)
IV
HF
L
EQQ
G
I
KI
V
T
G
IP
G
GS
I
LP
V
Y
D
A
L
SQS
-
T
Q
I
R
HI
LA
RHEQ
G
A
GFI
A
Q
G
M
A
RTD
GK
P
A
V
--
C
MAC
SGPG
A
TN
L
V
T
AI
A
D
A
RL
D
SI
PLI
C
I
T
G
QVPASM
IG
--
T
D
A
FQE
V
D
TY
--------
GISIPIT
K
HNY
LV
RHI
E
E
LP
QV
M
SD
A
FRI
A
Q
S
-
GRPG
P
V
W
I
D
I
P
K
DV
QTAVFEIE
---
TQPAMAEKAAAP-
-
-AFSEE-S
I
RD
A
AAM
I
NA
A
KR
P
V
L
YL
G
G
G
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
TTMT
L
M
A
LG
ML
P
KA
HP
LSL
GM
L
GM
H
G
VRSTNYI
L
Q
E
AD
L
L
IV
L
G
A
RF
DD
R
AIGKTEQ
F
C
P
-
NA
KI
IH
V
DID
R
A
E
L
GKIKQPH
VAI
QA
D
VDDV
L
AQ
L
I
PQ
V
EA----Q
P
R
A
--
-E
W
H
Q
LVADL
Q
REFPCPIP--KAC
D
----------------------------
P
-
LSHYGLINA
V
AA
----
CVDDNAII
T
T
DVG
QH
QM
W
T
A
QA
-
YPLNR
PR
QW
L
T
S
G
--------
GL
G
T
MG
F
GLP
A
AIGA
AL
A
N
P
DRK
V
L
C
FS
GDG
SLM
M
NIQ
E
MA
T
AS
E
NQ
L
D
V
K
I
I
LM
NN
EA
LG
L
V
H
-
QQQS
L
FYEQGVFAATYPGK
-----------
IN
F
MQ
I
A
A
G
F
G
LE
T
CD
L
NNEA
D
PQA
AL
QEIINR
---
PG
P
AL
IHV
R
ID
AE
--------
E
KVY
P
M
V
PP
GA
A
N
T
EM
fig|344601.5.peg.2544
Escherichia coli B171 (19-559/562)
IV
HF
L
EQQ
G
I
KI
V
T
G
IP
G
GS
I
LP
V
Y
D
A
L
SQS
-
T
Q
I
R
HI
LA
RHEQ
G
A
GFI
A
Q
G
M
A
RTD
GK
P
A
V
--
C
MAC
SGPG
A
TN
L
V
T
AI
A
D
A
RL
D
SI
PLI
C
I
T
G
QVPASM
IG
--
T
D
A
FQE
V
D
TY
--------
GISIPIT
K
HNY
LV
RHI
E
E
LP
QV
M
SD
A
FRI
A
Q
S
-
GRPG
P
V
W
I
D
I
P
K
DV
QTAVFEIE
---
TQPAMAEKAAAP-
-
-AFSEE-S
I
RD
A
AAM
I
NA
A
KR
P
V
L
YL
G
G
G
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
TTMT
L
M
A
LG
ML
P
KA
HP
LSL
GM
L
GM
H
G
VRSTNYI
L
Q
E
AD
L
L
IV
L
G
A
RF
DD
R
AIGKTEQ
F
C
P
-
NA
KI
IH
V
DID
R
A
E
L
GKIKQPH
VAI
QA
D
VDDV
L
AQ
L
I
PQ
V
EA----Q
P
R
A
--
-E
W
H
Q
LVADL
Q
REFPCPIP--KAC
D
----------------------------
P
-
LSHYGLINA
V
AA
----
CVDDNAII
T
T
DVG
QH
QM
W
T
A
QA
-
YPLNR
PR
QW
L
T
S
G
--------
GL
G
T
MG
F
GLP
A
AIGA
AL
A
N
P
DRK
V
L
C
FS
GDG
SLM
M
NIQ
E
MA
T
AS
E
NQ
L
D
V
K
I
I
LM
NN
EA
LG
L
V
H
-
QQQS
L
FYEQGVFAATYPGK
-----------
IN
F
MQ
I
A
A
G
F
G
LE
T
CD
L
NNEA
D
PQA
AL
QEIINR
---
PG
P
AL
IHV
R
ID
AE
--------
E
KVY
P
M
V
PP
GA
A
N
T
EM
fig|340184.3.peg.898
Escherichia coli B7A (19-559/562)
IV
HF
L
EQQ
G
I
KI
V
T
G
IP
G
GS
I
LP
V
Y
D
A
L
SQS
-
T
Q
I
R
HI
LA
RHEQ
G
A
GFI
A
Q
G
M
A
RTD
GK
P
A
V
--
C
MAC
SGPG
A
TN
L
V
T
AI
A
D
A
RL
D
SI
PLI
C
I
T
G
QVPASM
IG
--
T
D
A
FQE
V
D
TY
--------
GISIPIT
K
HNY
LV
RHI
E
E
LP
QV
M
SD
A
FRI
A
Q
S
-
GRPG
P
V
W
I
D
I
P
K
DV
QTAVFEIE
---
TQPAMAEKAAAP-
-
-AFSEE-S
I
RD
A
AAM
I
NA
A
KR
P
V
L
YL
G
G
G
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
TTMT
L
M
A
LG
ML
P
KA
HP
LSL
GM
L
GM
H
G
VRSTNYI
L
Q
E
AD
L
L
IV
L
G
A
RF
DD
R
AIGKTEQ
F
C
P
-
NA
KI
IH
V
DID
R
A
E
L
GKIKQPH
VAI
QA
D
VDDV
L
AQ
L
I
PQ
V
EA----Q
P
R
A
--
-E
W
H
Q
LVADL
Q
REFPCPIP--KAC
D
----------------------------
P
-
LSHYGLINA
V
AA
----
CVDDNAII
T
T
DVG
QH
QM
W
T
A
QA
-
YPLNR
PR
QW
L
T
S
G
--------
GL
G
T
MG
F
GLP
A
AIGA
AL
A
N
P
DRK
V
L
C
FS
GDG
SLM
M
NIQ
E
MA
T
AS
E
NQ
L
D
V
K
I
I
LM
NN
EA
LG
L
V
H
-
QQQS
L
FYEQGVFAATYPGK
-----------
IN
F
MQ
I
A
A
G
F
G
LE
T
CD
L
NNEA
D
PQA
AL
QEIINR
---
PG
P
AL
IHV
R
ID
AE
--------
E
KVY
P
M
V
PP
GA
A
N
T
EM
fig|340184.6.peg.933
Escherichia coli B7A (19-559/562)
IV
HF
L
EQQ
G
I
KI
V
T
G
IP
G
GS
I
LP
V
Y
D
A
L
SQS
-
T
Q
I
R
HI
LA
RHEQ
G
A
GFI
A
Q
G
M
A
RTD
GK
P
A
V
--
C
MAC
SGPG
A
TN
L
V
T
AI
A
D
A
RL
D
SI
PLI
C
I
T
G
QVPASM
IG
--
T
D
A
FQE
V
D
TY
--------
GISIPIT
K
HNY
LV
RHI
E
E
LP
QV
M
SD
A
FRI
A
Q
S
-
GRPG
P
V
W
I
D
I
P
K
DV
QTAVFEIE
---
TQPAMAEKAAAP-
-
-AFSEE-S
I
RD
A
AAM
I
NA
A
KR
P
V
L
YL
G
G
G
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
TTMT
L
M
A
LG
ML
P
KA
HP
LSL
GM
L
GM
H
G
VRSTNYI
L
Q
E
AD
L
L
IV
L
G
A
RF
DD
R
AIGKTEQ
F
C
P
-
NA
KI
IH
V
DID
R
A
E
L
GKIKQPH
VAI
QA
D
VDDV
L
AQ
L
I
PQ
V
EA----Q
P
R
A
--
-E
W
H
Q
LVADL
Q
REFPCPIP--KAC
D
----------------------------
P
-
LSHYGLINA
V
AA
----
CVDDNAII
T
T
DVG
QH
QM
W
T
A
QA
-
YPLNR
PR
QW
L
T
S
G
--------
GL
G
T
MG
F
GLP
A
AIGA
AL
A
N
P
DRK
V
L
C
FS
GDG
SLM
M
NIQ
E
MA
T
AS
E
NQ
L
D
V
K
I
I
LM
NN
EA
LG
L
V
H
-
QQQS
L
FYEQGVFAATYPGK
-----------
IN
F
MQ
I
A
A
G
F
G
LE
T
CD
L
NNEA
D
PQA
AL
QEIINR
---
PG
P
AL
IHV
R
ID
AE
--------
E
KVY
P
M
V
PP
GA
A
N
T
EM
fig|340185.3.peg.2148
Escherichia coli E22 (19-559/562)
IV
HF
L
EQQ
G
I
KI
V
T
G
IP
G
GS
I
LP
V
Y
D
A
L
SQS
-
T
Q
I
R
HI
LA
RHEQ
G
A
GFI
A
Q
G
M
A
RTD
GK
P
A
V
--
C
MAC
SGPG
A
TN
L
V
T
AI
A
D
A
RL
D
SI
PLI
C
I
T
G
QVPASM
IG
--
T
D
A
FQE
V
D
TY
--------
GISIPIT
K
HNY
LV
RHI
E
E
LP
QV
M
SD
A
FRI
A
Q
S
-
GRPG
P
V
W
I
D
I
P
K
DV
QTAVFEIE
---
TQPAMAEKAAAP-
-
-AFSEE-S
I
RD
A
AAM
I
NA
A
KR
P
V
L
YL
G
G
G
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
TTMT
L
M
A
LG
ML
P
KA
HP
LSL
GM
L
GM
H
G
VRSTNYI
L
Q
E
AD
L
L
IV
L
G
A
RF
DD
R
AIGKTEQ
F
C
P
-
NA
KI
IH
V
DID
R
A
E
L
GKIKQPH
VAI
QA
D
VDDV
L
AQ
L
I
PQ
V
EA----Q
P
R
A
--
-E
W
H
Q
LVADL
Q
REFPCPIP--KAC
D
----------------------------
P
-
LSHYGLINA
V
AA
----
CVDDNAII
T
T
DVG
QH
QM
W
T
A
QA
-
YPLNR
PR
QW
L
T
S
G
--------
GL
G
T
MG
F
GLP
A
AIGA
AL
A
N
P
DRK
V
L
C
FS
GDG
SLM
M
NIQ
E
MA
T
AS
E
NQ
L
D
V
K
I
I
LM
NN
EA
LG
L
V
H
-
QQQS
L
FYEQGVFAATYPGK
-----------
IN
F
MQ
I
A
A
G
F
G
LE
T
CD
L
NNEA
D
PQA
AL
QEIINR
---
PG
P
AL
IHV
R
ID
AE
--------
E
KVY
P
M
V
PP
GA
A
N
T
EM
fig|340185.4.peg.2277
Escherichia coli E22 (19-559/562)
IV
HF
L
EQQ
G
I
KI
V
T
G
IP
G
GS
I
LP
V
Y
D
A
L
SQS
-
T
Q
I
R
HI
LA
RHEQ
G
A
GFI
A
Q
G
M
A
RTD
GK
P
A
V
--
C
MAC
SGPG
A
TN
L
V
T
AI
A
D
A
RL
D
SI
PLI
C
I
T
G
QVPASM
IG
--
T
D
A
FQE
V
D
TY
--------
GISIPIT
K
HNY
LV
RHI
E
E
LP
QV
M
SD
A
FRI
A
Q
S
-
GRPG
P
V
W
I
D
I
P
K
DV
QTAVFEIE
---
TQPAMAEKAAAP-
-
-AFSEE-S
I
RD
A
AAM
I
NA
A
KR
P
V
L
YL
G
G
G
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
TTMT
L
M
A
LG
ML
P
KA
HP
LSL
GM
L
GM
H
G
VRSTNYI
L
Q
E
AD
L
L
IV
L
G
A
RF
DD
R
AIGKTEQ
F
C
P
-
NA
KI
IH
V
DID
R
A
E
L
GKIKQPH
VAI
QA
D
VDDV
L
AQ
L
I
PQ
V
EA----Q
P
R
A
--
-E
W
H
Q
LVADL
Q
REFPCPIP--KAC
D
----------------------------
P
-
LSHYGLINA
V
AA
----
CVDDNAII
T
T
DVG
QH
QM
W
T
A
QA
-
YPLNR
PR
QW
L
T
S
G
--------
GL
G
T
MG
F
GLP
A
AIGA
AL
A
N
P
DRK
V
L
C
FS
GDG
SLM
M
NIQ
E
MA
T
AS
E
NQ
L
D
V
K
I
I
LM
NN
EA
LG
L
V
H
-
QQQS
L
FYEQGVFAATYPGK
-----------
IN
F
MQ
I
A
A
G
F
G
LE
T
CD
L
NNEA
D
PQA
AL
QEIINR
---
PG
P
AL
IHV
R
ID
AE
--------
E
KVY
P
M
V
PP
GA
A
N
T
EM
fig|331111.12.peg.4417
Escherichia coli E24377A (19-559/562)
IV
HF
L
EQQ
G
I
KI
V
T
G
IP
G
GS
I
LP
V
Y
D
A
L
SQS
-
T
Q
I
R
HI
LA
RHEQ
G
A
GFI
A
Q
G
M
A
RTD
GK
P
A
V
--
C
MAC
SGPG
A
TN
L
V
T
AI
A
D
A
RL
D
SI
PLI
C
I
T
G
QVPASM
IG
--
T
D
A
FQE
V
D
TY
--------
GISIPIT
K
HNY
LV
RHI
E
E
LP
QV
M
SD
A
FRI
A
Q
S
-
GRPG
P
V
W
I
D
I
P
K
DV
QTAVFEIE
---
TQPAMAEKAAAP-
-
-AFSEE-S
I
RD
A
AAM
I
NA
A
KR
P
V
L
YL
G
G
G
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
TTMT
L
M
A
LG
ML
P
KA
HP
LSL
GM
L
GM
H
G
VRSTNYI
L
Q
E
AD
L
L
IV
L
G
A
RF
DD
R
AIGKTEQ
F
C
P
-
NA
KI
IH
V
DID
R
A
E
L
GKIKQPH
VAI
QA
D
VDDV
L
AQ
L
I
PQ
V
EA----Q
P
R
A
--
-E
W
H
Q
LVADL
Q
REFPCPIP--KAC
D
----------------------------
P
-
LSHYGLINA
V
AA
----
CVDDNAII
T
T
DVG
QH
QM
W
T
A
QA
-
YPLNR
PR
QW
L
T
S
G
--------
GL
G
T
MG
F
GLP
A
AIGA
AL
A
N
P
DRK
V
L
C
FS
GDG
SLM
M
NIQ
E
MA
T
AS
E
NQ
L
D
V
K
I
I
LM
NN
EA
LG
L
V
H
-
QQQS
L
FYKQGVFAATYPGK
-----------
IN
F
MQ
I
A
A
G
F
G
LE
T
CD
L
NNEA
D
PQA
AL
QEIINR
---
PG
P
AL
IHV
R
ID
AE
--------
E
KVY
P
M
V
PP
GA
A
N
T
EM
fig|331111.3.peg.1819
Escherichia coli E24377A (19-559/562)
IV
HF
L
EQQ
G
I
KI
V
T
G
IP
G
GS
I
LP
V
Y
D
A
L
SQS
-
T
Q
I
R
HI
LA
RHEQ
G
A
GFI
A
Q
G
M
A
RTD
GK
P
A
V
--
C
MAC
SGPG
A
TN
L
V
T
AI
A
D
A
RL
D
SI
PLI
C
I
T
G
QVPASM
IG
--
T
D
A
FQE
V
D
TY
--------
GISIPIT
K
HNY
LV
RHI
E
E
LP
QV
M
SD
A
FRI
A
Q
S
-
GRPG
P
V
W
I
D
I
P
K
DV
QTAVFEIE
---
TQPAMAEKAAAP-
-
-AFSEE-S
I
RD
A
AAM
I
NA
A
KR
P
V
L
YL
G
G
G
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
TTMT
L
M
A
LG
ML
P
KA
HP
LSL
GM
L
GM
H
G
VRSTNYI
L
Q
E
AD
L
L
IV
L
G
A
RF
DD
R
AIGKTEQ
F
C
P
-
NA
KI
IH
V
DID
R
A
E
L
GKIKQPH
VAI
QA
D
VDDV
L
AQ
L
I
PQ
V
EA----Q
P
R
A
--
-E
W
H
Q
LVADL
Q
REFPCPIP--KAC
D
----------------------------
P
-
LSHYGLINA
V
AA
----
CVDDNAII
T
T
DVG
QH
QM
W
T
A
QA
-
YPLNR
PR
QW
L
T
S
G
--------
GL
G
T
MG
F
GLP
A
AIGA
AL
A
N
P
DRK
V
L
C
FS
GDG
SLM
M
NIQ
E
MA
T
AS
E
NQ
L
D
V
K
I
I
LM
NN
EA
LG
L
V
H
-
QQQS
L
FYKQGVFAATYPGK
-----------
IN
F
MQ
I
A
A
G
F
G
LE
T
CD
L
NNEA
D
PQA
AL
QEIINR
---
PG
P
AL
IHV
R
ID
AE
--------
E
KVY
P
M
V
PP
GA
A
N
T
EM
fig|562.375.peg.327
Escherichia coli EC4100B (19-559/562)
IV
HF
L
EQQ
G
I
KI
V
T
G
IP
G
GS
I
LP
V
Y
D
A
L
SQS
-
T
Q
I
R
HI
LA
RHEQ
G
A
GFI
A
Q
G
M
A
RTD
GK
P
A
V
--
C
MAC
SGPG
A
TN
L
V
T
AI
A
D
A
RL
D
SI
PLI
C
I
T
G
QVPASM
IG
--
T
D
A
FQE
V
D
TY
--------
GISIPIT
K
HNY
LV
RHI
E
E
LP
QV
M
SD
A
FRI
A
Q
S
-
GRPG
P
V
W
I
D
I
P
K
DV
QTAVFEIE
---
TQPAMAEKAAAP-
-
-AFSEE-S
I
RD
A
AAM
I
NA
A
KR
P
V
L
YL
G
G
G
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
TTMT
L
M
A
LG
ML
P
KA
HP
LSL
GM
L
GM
H
G
VRSTNYI
L
Q
E
AD
L
L
IV
L
G
A
RF
DD
R
AIGKTEQ
F
C
P
-
NA
KI
IH
V
DID
R
A
E
L
GKIKQPH
VAI
QA
D
VDDV
L
AQ
L
I
PQ
V
EA----Q
P
R
A
--
-E
W
H
Q
LVADL
Q
REFPCPIP--KAC
D
----------------------------
P
-
LSHYGLINA
V
AA
----
CVDDNAII
T
T
DVG
QH
QM
W
T
A
QA
-
YPLNR
PR
QW
L
T
S
G
--------
GL
G
T
MG
F
GLP
A
AIGA
AL
A
N
P
DRK
V
L
C
FS
GDG
SLM
M
NIQ
E
MA
T
AS
E
NQ
L
D
V
K
I
I
LM
NN
EA
LG
L
V
H
-
QQQS
L
FYEQGVFAATYPGK
-----------
IN
F
MQ
I
A
A
G
F
G
LE
T
CD
L
NNEA
D
PQA
AL
QEIINR
---
PG
P
AL
IHV
R
ID
AE
--------
E
KVY
P
M
V
PP
GA
A
N
T
EM
fig|585034.4.peg.3764
Escherichia coli IAI1 (19-559/562)
IV
HF
L
EQQ
G
I
KI
V
T
G
IP
G
GS
I
LP
V
Y
D
A
L
SQS
-
T
Q
I
R
HI
LA
RHEQ
G
A
GFI
A
Q
G
M
A
RTD
GK
P
A
V
--
C
MAC
SGPG
A
TN
L
V
T
AI
A
D
A
RL
D
SI
PLI
C
I
T
G
QVPASM
IG
--
T
D
A
FQE
V
D
TY
--------
GISIPIT
K
HNY
LV
RHI
E
E
LP
QV
M
SD
A
FRI
A
Q
S
-
GRPG
P
V
W
I
D
I
P
K
DV
QTAVFEIE
---
TQPAMAEKAAAP-
-
-AFSEE-S
I
RD
A
AAM
I
NA
A
KR
P
V
L
YL
G
G
G
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
TTMT
L
M
A
LG
ML
P
KA
HP
LSL
GM
L
GM
H
G
VRSTNYI
L
Q
E
AD
L
L
IV
L
G
A
RF
DD
R
AIGKTEQ
F
C
P
-
NA
KI
IH
V
DID
R
A
E
L
GKIKQPH
VAI
QA
D
VDDV
L
AQ
L
I
PQ
V
EA----Q
P
R
A
--
-E
W
H
Q
LVADL
Q
REFPCPIP--KAC
D
----------------------------
P
-
LSHYGLINA
V
AA
----
CVDDNAII
T
T
DVG
QH
QM
W
T
A
QA
-
YPLNR
PR
QW
L
T
S
G
--------
GL
G
T
MG
F
GLP
A
AIGA
AL
A
N
P
DRK
V
L
C
FS
GDG
SLM
M
NIQ
E
MA
T
AS
E
NQ
L
D
V
K
I
I
LM
NN
EA
LG
L
V
H
-
QQQS
L
FYEQGVFAATYPGK
-----------
IN
F
MQ
I
A
A
G
F
G
LE
T
CD
L
NNEA
D
PQA
AL
QEIINR
---
PG
P
AL
IHV
R
ID
AE
--------
E
KVY
P
M
V
PP
GA
A
N
T
EM
fig|585034.5.peg.3761
Escherichia coli IAI1 (19-559/562)
IV
HF
L
EQQ
G
I
KI
V
T
G
IP
G
GS
I
LP
V
Y
D
A
L
SQS
-
T
Q
I
R
HI
LA
RHEQ
G
A
GFI
A
Q
G
M
A
RTD
GK
P
A
V
--
C
MAC
SGPG
A
TN
L
V
T
AI
A
D
A
RL
D
SI
PLI
C
I
T
G
QVPASM
IG
--
T
D
A
FQE
V
D
TY
--------
GISIPIT
K
HNY
LV
RHI
E
E
LP
QV
M
SD
A
FRI
A
Q
S
-
GRPG
P
V
W
I
D
I
P
K
DV
QTAVFEIE
---
TQPAMAEKAAAP-
-
-AFSEE-S
I
RD
A
AAM
I
NA
A
KR
P
V
L
YL
G
G
G
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
TTMT
L
M
A
LG
ML
P
KA
HP
LSL
GM
L
GM
H
G
VRSTNYI
L
Q
E
AD
L
L
IV
L
G
A
RF
DD
R
AIGKTEQ
F
C
P
-
NA
KI
IH
V
DID
R
A
E
L
GKIKQPH
VAI
QA
D
VDDV
L
AQ
L
I
PQ
V
EA----Q
P
R
A
--
-E
W
H
Q
LVADL
Q
REFPCPIP--KAC
D
----------------------------
P
-
LSHYGLINA
V
AA
----
CVDDNAII
T
T
DVG
QH
QM
W
T
A
QA
-
YPLNR
PR
QW
L
T
S
G
--------
GL
G
T
MG
F
GLP
A
AIGA
AL
A
N
P
DRK
V
L
C
FS
GDG
SLM
M
NIQ
E
MA
T
AS
E
NQ
L
D
V
K
I
I
LM
NN
EA
LG
L
V
H
-
QQQS
L
FYEQGVFAATYPGK
-----------
IN
F
MQ
I
A
A
G
F
G
LE
T
CD
L
NNEA
D
PQA
AL
QEIINR
---
PG
P
AL
IHV
R
ID
AE
--------
E
KVY
P
M
V
PP
GA
A
N
T
EM
fig|595495.4.peg.2787
Escherichia coli KO11 (19-559/562)
IV
HF
L
EQQ
G
I
KI
V
T
G
IP
G
GS
I
LP
V
Y
D
A
L
SQS
-
T
Q
I
R
HI
LA
RHEQ
G
A
GFI
A
Q
G
M
A
RTD
GK
P
A
V
--
C
MAC
SGPG
A
TN
L
V
T
AI
A
D
A
RL
D
SI
PLI
C
I
T
G
QVPASM
IG
--
T
D
A
FQE
V
D
TY
--------
GISIPIT
K
HNY
LV
RHI
E
E
LP
QV
M
SD
A
FRI
A
Q
S
-
GRPG
P
V
W
I
D
I
P
K
DV
QTAVFEIE
---
TQPAMAEKAAAP-
-
-AFSEE-S
I
RD
A
AAM
I
NA
A
KR
P
V
L
YL
G
G
G
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
TTMT
L
M
A
LG
ML
P
KA
HP
LSL
GM
L
GM
H
G
VRSTNYI
L
Q
E
AD
L
L
IV
L
G
A
RF
DD
R
AIGKTEQ
F
C
P
-
NA
KI
IH
V
DID
R
A
E
L
GKIKQPH
VAI
QA
D
VDDV
L
AQ
L
I
PQ
V
EA----Q
P
R
A
--
-E
W
H
Q
LVADL
Q
REFPCPIP--KAC
D
----------------------------
P
-
LSHYGLINA
V
AA
----
CVDDNAII
T
T
DVG
QH
QM
W
T
A
QA
-
YPLNR
PR
QW
L
T
S
G
--------
GL
G
T
MG
F
GLP
A
AIGA
AL
A
N
P
DRK
V
L
C
FS
GDG
SLM
M
NIQ
E
MA
T
AS
E
NQ
L
D
V
K
I
I
LM
NN
EA
LG
L
V
H
-
QQQS
L
FYEQGVFAATYPGK
-----------
IN
F
MQ
I
A
A
G
F
G
LE
T
CD
L
NNEA
D
PQA
AL
QEIINR
---
PG
P
AL
IHV
R
ID
AE
--------
E
KVY
P
M
V
PP
GA
A
N
T
EM
fig|679207.4.peg.100
Escherichia coli MS 107-1 (19-559/562)
IV
HF
L
EQQ
G
I
KI
V
T
G
IP
G
GS
I
LP
V
Y
D
A
L
SQS
-
T
Q
I
R
HI
LA
RHEQ
G
A
GFI
A
Q
G
M
A
RTD
GK
P
A
V
--
C
MAC
SGPG
A
TN
L
V
T
AI
A
D
A
RL
D
SI
PLI
C
I
T
G
QVPASM
IG
--
T
D
A
FQE
V
D
TY
--------
GISIPIT
K
HNY
LV
RHI
E
E
LP
QV
M
SD
A
FRI
A
Q
S
-
GRPG
P
V
W
I
D
I
P
K
DV
QTAVFEIE
---
TQPAMAEKAAAP-
-
-AFSEE-S
I
RD
A
AAM
I
NA
A
KR
P
V
L
YL
G
G
G
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
TTMT
L
M
A
LG
ML
P
KA
HP
LSL
GM
L
GM
H
G
VRSTNYI
L
Q
E
AD
L
L
IV
L
G
A
RF
DD
R
AIGKTEQ
F
C
P
-
NA
KI
IH
V
DID
R
A
E
L
GKIKQPH
VAI
QA
D
VDDV
L
AQ
L
I
PQ
V
EA----Q
P
R
A
--
-E
W
H
Q
LVADL
Q
REFPCPIP--KAC
D
----------------------------
P
-
LSHYGLINA
V
AA
----
CVDDNAII
T
T
DVG
QH
QM
W
T
A
QA
-
YPLNR
PR
QW
L
T
S
G
--------
GL
G
T
MG
F
GLP
A
AIGA
AL
A
N
P
DRK
V
L
C
FS
GDG
SLM
M
NIQ
E
MA
T
AS
E
NQ
L
D
V
K
I
I
LM
NN
EA
LG
L
V
H
-
QQQS
L
FYEQGVFAATYPGK
-----------
IN
F
MQ
I
A
A
G
F
G
LE
T
CD
L
NNEA
D
PQA
AL
QEIINR
---
PG
P
AL
IHV
R
ID
AE
--------
E
KVY
P
M
V
PP
GA
A
N
T
EM
fig|679206.4.peg.2219
Escherichia coli MS 119-7 (19-559/562)
IV
HF
L
EQQ
G
I
KI
V
T
G
IP
G
GS
I
LP
V
Y
D
A
L
SQS
-
T
Q
I
R
HI
LA
RHEQ
G
A
GFI
A
Q
G
M
A
RTD
GK
P
A
V
--
C
MAC
SGPG
A
TN
L
V
T
AI
A
D
A
RL
D
SI
PLI
C
I
T
G
QVPASM
IG
--
T
D
A
FQE
V
D
TY
--------
GISIPIT
K
HNY
LV
RHI
E
E
LP
QV
M
SD
A
FRI
A
Q
S
-
GRPG
P
V
W
I
D
I
P
K
DV
QTAVFEIE
---
TQPAMAEKAAAP-
-
-AFSEE-S
I
RD
A
AAM
I
NA
A
KR
P
V
L
YL
G
G
G
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
TTMT
L
M
A
LG
ML
P
KA
HP
LSL
GM
L
GM
H
G
VRSTNYI
L
Q
E
AD
L
L
IV
L
G
A
RF
DD
R
AIGKTEQ
F
C
P
-
NA
KI
IH
V
DID
R
A
E
L
GKIKQPH
VAI
QA
D
VDDV
L
AQ
L
I
PQ
V
EA----Q
P
R
A
--
-E
W
H
Q
LVADL
Q
REFPCPIP--KAC
D
----------------------------
P
-
LSHYGLINA
V
AA
----
CVDDNAII
T
T
DVG
QH
QM
W
T
A
QA
-
YPLNR
PR
QW
L
T
S
G
--------
GL
G
T
MG
F
GLP
A
AIGA
AL
A
N
P
DRK
V
L
C
FS
GDG
SLM
M
NIQ
E
MA
T
AS
E
NQ
L
D
V
K
I
I
LM
NN
EA
LG
L
V
H
-
QQQS
L
FYEQGVFAATYPGK
-----------
IN
F
MQ
I
A
A
G
F
G
LE
T
CD
L
NNEA
D
PQA
AL
QEIINR
---
PG
P
AL
IHV
R
ID
AE
--------
E
KVY
P
M
V
PP
GA
A
N
T
EM
fig|679205.4.peg.4732
Escherichia coli MS 124-1 (19-559/562)
IV
HF
L
EQQ
G
I
KI
V
T
G
IP
G
GS
I
LP
V
Y
D
A
L
SQS
-
T
Q
I
R
HI
LA
RHEQ
G
A
GFI
A
Q
G
M
A
RTD
GK
P
A
V
--
C
MAC
SGPG
A
TN
L
V
T
AI
A
D
A
RL
D
SI
PLI
C
I
T
G
QVPASM
IG
--
T
D
A
FQE
V
D
TY
--------
GISIPIT
K
HNY
LV
RHI
E
E
LP
QV
M
SD
A
FRI
A
Q
S
-
GRPG
P
V
W
I
D
I
P
K
DV
QTAVFEIE
---
TQPAMAEKAAAP-
-
-AFSEE-S
I
RD
A
AAM
I
NA
A
KR
P
V
L
YL
G
G
G
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
TTMT
L
M
A
LG
ML
P
KA
HP
LSL
GM
L
GM
H
G
VRSTNYI
L
Q
E
AD
L
L
IV
L
G
A
RF
DD
R
AIGKTEQ
F
C
P
-
NA
KI
IH
V
DID
R
A
E
L
GKIKQPH
VAI
QA
D
VDDV
L
AQ
L
I
PQ
V
EA----Q
P
R
A
--
-E
W
H
Q
LVADL
Q
REFPCPIP--KAC
D
----------------------------
P
-
LSHYGLINA
V
AA
----
CVDDNAII
T
T
DVG
QH
QM
W
T
A
QA
-
YPLNR
PR
QW
L
T
S
G
--------
GL
G
T
MG
F
GLP
A
AIGA
AL
A
N
P
DRK
V
L
C
FS
GDG
SLM
M
NIQ
E
MA
T
AS
E
NQ
L
D
V
K
I
I
LM
NN
EA
LG
L
V
H
-
QQQS
L
FYEQGVFAATYPGK
-----------
IN
F
MQ
I
A
A
G
F
G
LE
T
CD
L
NNEA
D
PQA
AL
QEIINR
---
PG
P
AL
IHV
R
ID
AE
--------
E
KVY
P
M
V
PP
GA
A
N
T
EM
fig|679204.3.peg.2916
Escherichia coli MS 145-7 (19-559/562)
IV
HF
L
EQQ
G
I
KI
V
T
G
IP
G
GS
I
LP
V
Y
D
A
L
SQS
-
T
Q
I
R
HI
LA
RHEQ
G
A
GFI
A
Q
G
M
A
RTD
GK
P
A
V
--
C
MAC
SGPG
A
TN
L
V
T
AI
A
D
A
RL
D
SI
PLI
C
I
T
G
QVPASM
IG
--
T
D
A
FQE
V
D
TY
--------
GISIPIT
K
HNY
LV
RHI
E
E
LP
QV
M
SD
A
FRI
A
Q
S
-
GRPG
P
V
W
I
D
I
P
K
DV
QTAVFEIE
---
TQPAMAEKAAAP-
-
-AFSEE-S
I
RD
A
AAM
I
NA
A
KR
P
V
L
YL
G
G
G
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
TTMT
L
M
A
LG
ML
P
KA
HP
LSL
GM
L
GM
H
G
VRSTNYI
L
Q
E
AD
L
L
IV
L
G
A
RF
DD
R
AIGKTEQ
F
C
P
-
NA
KI
IH
V
DID
R
A
E
L
GKIKQPH
VAI
QA
D
VDDV
L
AQ
L
I
PQ
V
EA----Q
P
R
A
--
-E
W
H
Q
LVADL
Q
REFPCPIP--KAC
D
----------------------------
P
-
LSHYGLINA
V
AA
----
CVDDNAII
T
T
DVG
QH
QM
W
T
A
QA
-
YPLNR
PR
QW
L
T
S
G
--------
GL
G
T
MG
F
GLP
A
AIGA
AL
A
N
P
DRK
V
L
C
FS
GDG
SLM
M
NIQ
E
MA
T
AS
E
NQ
L
D
V
K
I
I
LM
NN
EA
LG
L
V
H
-
QQQS
L
FYEQGVFAATYPGK
-----------
IN
F
MQ
I
A
A
G
F
G
LE
T
CD
L
NNEA
D
PQA
AL
QEIINR
---
PG
P
AL
IHV
R
ID
AE
--------
E
KVY
P
M
V
PP
GA
A
N
T
EM
fig|749545.3.peg.3403
Escherichia coli MS 182-1 (19-559/562)
IV
HF
L
EQQ
G
I
KI
V
T
G
IP
G
GS
I
LP
V
Y
D
A
L
SQS
-
T
Q
I
R
HI
LA
RHEQ
G
A
GFI
A
Q
G
M
A
RTD
GK
P
A
V
--
C
MAC
SGPG
A
TN
L
V
T
AI
A
D
A
RL
D
SI
PLI
C
I
T
G
QVPASM
IG
--
T
D
A
FQE
V
D
TY
--------
GISIPIT
K
HNY
LV
RHI
E
E
LP
QV
M
SD
A
FRI
A
Q
S
-
GRPG
P
V
W
I
D
I
P
K
DV
QTAVFEIE
---
TQPAMAEKAAAP-
-
-AFSEE-S
I
RD
A
AAM
I
NA
A
KR
P
V
L
YL
G
G
G
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
TTMT
L
M
A
LG
ML
P
KA
HP
LSL
GM
L
GM
H
G
VRSTNYI
L
Q
E
AD
L
L
IV
L
G
A
RF
DD
R
AIGKTEQ
F
C
P
-
NA
KI
IH
V
DID
R
A
E
L
GKIKQPH
VAI
QA
D
VDDV
L
AQ
L
I
PQ
V
EA----Q
P
R
A
--
-E
W
H
Q
LVADL
Q
REFPCPIP--KAC
D
----------------------------
P
-
LSHYGLINA
V
AA
----
CVDDNAII
T
T
DVG
QH
QM
W
T
A
QA
-
YPLNR
PR
QW
L
T
S
G
--------
GL
G
T
MG
F
GLP
A
AIGA
AL
A
N
P
DRK
V
L
C
FS
GDG
SLM
M
NIQ
E
MA
T
AS
E
NQ
L
D
V
K
I
I
LM
NN
EA
LG
L
V
H
-
QQQS
L
FYEQGVFAATYPGK
-----------
IN
F
MQ
I
A
A
G
F
G
LE
T
CD
L
NNEA
D
PQA
AL
QEIINR
---
PG
P
AL
IHV
R
ID
AE
--------
E
KVY
P
M
V
PP
GA
A
N
T
EM
fig|749532.3.peg.429
Escherichia coli MS 78-1 (19-559/562)
IV
HF
L
EQQ
G
I
KI
V
T
G
IP
G
GS
I
LP
V
Y
D
A
L
SQS
-
T
Q
I
R
HI
LA
RHEQ
G
A
GFI
A
Q
G
M
A
RTD
GK
P
A
V
--
C
MAC
SGPG
A
TN
L
V
T
AI
A
D
A
RL
D
SI
PLI
C
I
T
G
QVPASM
IG
--
T
D
A
FQE
V
D
TY
--------
GISIPIT
K
HNY
LV
RHI
E
E
LP
QV
M
SD
A
FRI
A
Q
S
-
GRPG
P
V
W
I
D
I
P
K
DV
QTAVFEIE
---
TQPAMAEKAAAP-
-
-AFSEE-S
I
RD
A
AAM
I
NA
A
KR
P
V
L
YL
G
G
G
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
TTMT
L
M
A
LG
ML
P
KA
HP
LSL
GM
L
GM
H
G
VRSTNYI
L
Q
E
AD
L
L
IV
L
G
A
RF
DD
R
AIGKTEQ
F
C
P
-
NA
KI
IH
V
DID
R
A
E
L
GKIKQPH
VAI
QA
D
VDDV
L
AQ
L
I
PQ
V
EA----Q
P
R
A
--
-E
W
H
Q
LVADL
Q
REFPCPIP--KAC
D
----------------------------
P
-
LSHYGLINA
V
AA
----
CVDDNAII
T
T
DVG
QH
QM
W
T
A
QA
-
YPLNR
PR
QW
L
T
S
G
--------
GL
G
T
MG
F
GLP
A
AIGA
AL
A
N
P
DRK
V
L
C
FS
GDG
SLM
M
NIQ
E
MA
T
AS
E
NQ
L
D
V
K
I
I
LM
NN
EA
LG
L
V
H
-
QQQS
L
FYEQGVFAATYPGK
-----------
IN
F
MQ
I
A
A
G
F
G
LE
T
CD
L
NNEA
D
PQA
AL
QEIINR
---
PG
P
AL
IHV
R
ID
AE
--------
E
KVY
P
M
V
PP
GA
A
N
T
EM
fig|749533.3.peg.1134
Escherichia coli MS 84-1 (19-559/562)
IV
HF
L
EQQ
G
I
KI
V
T
G
IP
G
GS
I
LP
V
Y
D
A
L
SQS
-
T
Q
I
R
HI
LA
RHEQ
G
A
GFI
A
Q
G
M
A
RTD
GK
P
A
V
--
C
MAC
SGPG
A
TN
L
V
T
AI
A
D
A
RL
D
SI
PLI
C
I
T
G
QVPASM
IG
--
T
D
A
FQE
V
D
TY
--------
GISIPIT
K
HNY
LV
RHI
E
E
LP
QV
M
SD
A
FRI
A
Q
S
-
GRPG
P
V
W
I
D
I
P
K
DV
QTAVFEIE
---
TQPAMAEKAAAP-
-
-AFSEE-S
I
RD
A
AAM
I
NA
A
KR
P
V
L
YL
G
G
G
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
TTMT
L
M
A
LG
ML
P
KA
HP
LSL
GM
L
GM
H
G
VRSTNYI
L
Q
E
AD
L
L
IV
L
G
A
RF
DD
R
AIGKTEQ
F
C
P
-
NA
KI
IH
V
DID
R
A
E
L
GKIKQPH
VAI
QA
D
VDDV
L
AQ
L
I
PQ
V
EA----Q
P
R
A
--
-E
W
H
Q
LVADL
Q
REFPCPIP--KAC
D
----------------------------
P
-
LSHYGLINA
V
AA
----
CVDDNAII
T
T
DVG
QH
QM
W
T
A
QA
-
YPLNR
PR
QW
L
T
S
G
--------
GL
G
T
MG
F
GLP
A
AIGA
AL
A
N
P
DRK
V
L
C
FS
GDG
SLM
M
NIQ
E
MA
T
AS
E
NQ
L
D
V
K
I
I
LM
NN
EA
LG
L
V
H
-
QQQS
L
FYEQGVFAATYPGK
-----------
IN
F
MQ
I
A
A
G
F
G
LE
T
CD
L
NNEA
D
PQA
AL
QEIINR
---
PG
P
AL
IHV
R
ID
AE
--------
E
KVY
P
M
V
PP
GA
A
N
T
EM
fig|585395.4.peg.4694
Escherichia coli O103:H2 str. 12009 (19-559/562)
IV
HF
L
EQQ
G
I
KI
V
T
G
IP
G
GS
I
LP
V
Y
D
A
L
SQS
-
T
Q
I
R
HI
LA
RHEQ
G
A
GFI
A
Q
G
M
A
RTD
GK
P
A
V
--
C
MAC
SGPG
A
TN
L
V
T
AI
A
D
A
RL
D
SI
PLI
C
I
T
G
QVPASM
IG
--
T
D
A
FQE
V
D
TY
--------
GISIPIT
K
HNY
LV
RHI
E
E
LP
QV
M
SD
A
FRI
A
Q
S
-
GRPG
P
V
W
I
D
I
P
K
DV
QTAVFEIE
---
TQPAMAEKAAAP-
-
-AFSEE-S
I
RD
A
AAM
I
NA
A
KR
P
V
L
YL
G
G
G
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
TTMT
L
M
A
LG
ML
P
KA
HP
LSL
GM
L
GM
H
G
VRSTNYI
L
Q
E
AD
L
L
IV
L
G
A
RF
DD
R
AIGKTEQ
F
C
P
-
NA
KI
IH
V
DID
R
A
E
L
GKIKQPH
VAI
QA
D
VDDV
L
AQ
L
I
PQ
V
EA----Q
P
R
A
--
-E
W
H
Q
LVADL
Q
REFPCPIP--KAC
D
----------------------------
P
-
LSHYGLINA
V
AA
----
CVDDNAII
T
T
DVG
QH
QM
W
T
A
QA
-
YPLNR
PR
QW
L
T
S
G
--------
GL
G
T
MG
F
GLP
A
AIGA
AL
A
N
P
DRK
V
L
C
FS
GDG
SLM
M
NIQ
E
MA
T
AS
E
NQ
L
D
V
K
I
I
LM
NN
EA
LG
L
V
H
-
QQQS
L
FYEQGVFAATYPGK
-----------
IN
F
MQ
I
A
A
G
F
G
LE
T
CD
L
NNEA
D
PQA
AL
QEIINR
---
PG
P
AL
IHV
R
ID
AE
--------
E
KVY
P
M
V
PP
GA
A
N
T
EM
fig|585396.4.peg.4656
Escherichia coli O111:H- str. 11128 (19-559/562)
IV
HF
L
EQQ
G
I
KI
V
T
G
IP
G
GS
I
LP
V
Y
D
A
L
SQS
-
T
Q
I
R
HI
LA
RHEQ
G
A
GFI
A
Q
G
M
A
RTD
GK
P
A
V
--
C
MAC
SGPG
A
TN
L
V
T
AI
A
D
A
RL
D
SI
PLI
C
I
T
G
QVPASM
IG
--
T
D
A
FQE
V
D
TY
--------
GISIPIT
K
HNY
LV
RHI
E
E
LP
QV
M
SD
A
FRI
A
Q
S
-
GRPG
P
V
W
I
D
I
P
K
DV
QTAVFEIE
---
TQPAMAEKAAAP-
-
-AFSEE-S
I
RD
A
AAM
I
NA
A
KR
P
V
L
YL
G
G
G
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
TTMT
L
M
A
LG
ML
P
KA
HP
LSL
GM
L
GM
H
G
VRSTNYI
L
Q
E
AD
L
L
IV
L
G
A
RF
DD
R
AIGKTEQ
F
C
P
-
NA
KI
IH
V
DID
R
A
E
L
GKIKQPH
VAI
QA
D
VDDV
L
AQ
L
I
PQ
V
EA----Q
P
R
A
--
-E
W
H
Q
LVADL
Q
REFPCPIP--KAC
D
----------------------------
P
-
LSHYGLINA
V
AA
----
CVDDNAII
T
T
DVG
QH
QM
W
T
A
QA
-
YPLNR
PR
QW
L
T
S
G
--------
GL
G
T
MG
F
GLP
A
AIGA
AL
A
N
P
DRK
V
L
C
FS
GDG
SLM
M
NIQ
E
MA
T
AS
E
NQ
L
D
V
K
I
I
LM
NN
EA
LG
L
V
H
-
QQQS
L
FYEQGVFAATYPGK
-----------
IN
F
MQ
I
A
A
G
F
G
LE
T
CD
L
NNEA
D
PQA
AL
QEIINR
---
PG
P
AL
IHV
R
ID
AE
--------
E
KVY
P
M
V
PP
GA
A
N
T
EM
fig|409438.11.peg.4129
Escherichia coli SE11 (19-559/562)
IV
HF
L
EQQ
G
I
KI
V
T
G
IP
G
GS
I
LP
V
Y
D
A
L
SQS
-
T
Q
I
R
HI
LA
RHEQ
G
A
GFI
A
Q
G
M
A
RTD
GK
P
A
V
--
C
MAC
SGPG
A
TN
L
V
T
AI
A
D
A
RL
D
SI
PLI
C
I
T
G
QVPASM
IG
--
T
D
A
FQE
V
D
TY
--------
GISIPIT
K
HNY
LV
RHI
E
E
LP
QV
M
SD
A
FRI
A
Q
S
-
GRPG
P
V
W
I
D
I
P
K
DV
QTAVFEIE
---
TQPAMAEKAAAP-
-
-AFSEE-S
I
RD
A
AAM
I
NA
A
KR
P
V
L
YL
G
G
G
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
TTMT
L
M
A
LG
ML
P
KA
HP
LSL
GM
L
GM
H
G
VRSTNYI
L
Q
E
AD
L
L
IV
L
G
A
RF
DD
R
AIGKTEQ
F
C
P
-
NA
KI
IH
V
DID
R
A
E
L
GKIKQPH
VAI
QA
D
VDDV
L
AQ
L
I
PQ
V
EA----Q
P
R
A
--
-E
W
H
Q
LVADL
Q
REFPCPIP--KAC
D
----------------------------
P
-
LSHYGLINA
V
AA
----
CVDDNAII
T
T
DVG
QH
QM
W
T
A
QA
-
YPLNR
PR
QW
L
T
S
G
--------
GL
G
T
MG
F
GLP
A
AIGA
AL
A
N
P
DRK
V
L
C
FS
GDG
SLM
M
NIQ
E
MA
T
AS
E
NQ
L
D
V
K
I
I
LM
NN
EA
LG
L
V
H
-
QQQS
L
FYEQGVFAATYPGK
-----------
IN
F
MQ
I
A
A
G
F
G
LE
T
CD
L
NNEA
D
PQA
AL
QEIINR
---
PG
P
AL
IHV
R
ID
AE
--------
E
KVY
P
M
V
PP
GA
A
N
T
EM
fig|656443.3.peg.4607
Escherichia coli TA271 (19-559/562)
IV
HF
L
EQQ
G
I
KI
V
T
G
IP
G
GS
I
LP
V
Y
D
A
L
SQS
-
T
Q
I
R
HI
LA
RHEQ
G
A
GFI
A
Q
G
M
A
RTD
GK
P
A
V
--
C
MAC
SGPG
A
TN
L
V
T
AI
A
D
A
RL
D
SI
PLI
C
I
T
G
QVPASM
IG
--
T
D
A
FQE
V
D
TY
--------
GISIPIT
K
HNY
LV
RHI
E
E
LP
QV
M
SD
A
FRI
A
Q
S
-
GRPG
P
V
W
I
D
I
P
K
DV
QTAVFEIE
---
TQPAMAEKAAAP-
-
-AFSEE-S
I
RD
A
AAM
I
NA
A
KR
P
V
L
YL
G
G
G
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
TTMT
L
M
A
LG
ML
P
KA
HP
LSL
GM
L
GM
H
G
VRSTNYI
L
Q
E
AD
L
L
IV
L
G
A
RF
DD
R
AIGKTEQ
F
C
P
-
NA
KI
IH
V
DID
R
A
E
L
GKIKQPH
VAI
QA
D
VDDV
L
AQ
L
I
PQ
V
EA----Q
P
R
A
--
-E
W
H
Q
LVADL
Q
REFPCPIP--KAC
D
----------------------------
P
-
LSHYGLINA
V
AA
----
CVDDNAII
T
T
DVG
QH
QM
W
T
A
QA
-
YPLNR
PR
QW
L
T
S
G
--------
GL
G
T
MG
F
GLP
A
AIGA
AL
A
N
P
DRK
V
L
C
FS
GDG
SLM
M
NIQ
E
MA
T
AS
E
NQ
L
D
V
K
I
I
LM
NN
EA
LG
L
V
H
-
QQQS
L
FYEQGVFAATYPGK
-----------
IN
F
MQ
I
A
A
G
F
G
LE
T
CD
L
NNEA
D
PQA
AL
QEIINR
---
PG
P
AL
IHV
R
ID
AE
--------
E
KVY
P
M
V
PP
GA
A
N
T
EM
fig|566546.3.peg.3326
Escherichia coli W (19-559/562)
IV
HF
L
EQQ
G
I
KI
V
T
G
IP
G
GS
I
LP
V
Y
D
A
L
SQS
-
T
Q
I
R
HI
LA
RHEQ
G
A
GFI
A
Q
G
M
A
RTD
GK
P
A
V
--
C
MAC
SGPG
A
TN
L
V
T
AI
A
D
A
RL
D
SI
PLI
C
I
T
G
QVPASM
IG
--
T
D
A
FQE
V
D
TY
--------
GISIPIT
K
HNY
LV
RHI
E
E
LP
QV
M
SD
A
FRI
A
Q
S
-
GRPG
P
V
W
I
D
I
P
K
DV
QTAVFEIE
---
TQPAMAEKAAAP-
-
-AFSEE-S
I
RD
A
AAM
I
NA
A
KR
P
V
L
YL
G
G
G
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
TTMT
L
M
A
LG
ML
P
KA
HP
LSL
GM
L
GM
H
G
VRSTNYI
L
Q
E
AD
L
L
IV
L
G
A
RF
DD
R
AIGKTEQ
F
C
P
-
NA
KI
IH
V
DID
R
A
E
L
GKIKQPH
VAI
QA
D
VDDV
L
AQ
L
I
PQ
V
EA----Q
P
R
A
--
-E
W
H
Q
LVADL
Q
REFPCPIP--KAC
D
----------------------------
P
-
LSHYGLINA
V
AA
----
CVDDNAII
T
T
DVG
QH
QM
W
T
A
QA
-
YPLNR
PR
QW
L
T
S
G
--------
GL
G
T
MG
F
GLP
A
AIGA
AL
A
N
P
DRK
V
L
C
FS
GDG
SLM
M
NIQ
E
MA
T
AS
E
NQ
L
D
V
K
I
I
LM
NN
EA
LG
L
V
H
-
QQQS
L
FYEQGVFAATYPGK
-----------
IN
F
MQ
I
A
A
G
F
G
LE
T
CD
L
NNEA
D
PQA
AL
QEIINR
---
PG
P
AL
IHV
R
ID
AE
--------
E
KVY
P
M
V
PP
GA
A
N
T
EM
fig|566546.4.peg.3928
Escherichia coli W (19-559/562)
IV
HF
L
EQQ
G
I
KI
V
T
G
IP
G
GS
I
LP
V
Y
D
A
L
SQS
-
T
Q
I
R
HI
LA
RHEQ
G
A
GFI
A
Q
G
M
A
RTD
GK
P
A
V
--
C
MAC
SGPG
A
TN
L
V
T
AI
A
D
A
RL
D
SI
PLI
C
I
T
G
QVPASM
IG
--
T
D
A
FQE
V
D
TY
--------
GISIPIT
K
HNY
LV
RHI
E
E
LP
QV
M
SD
A
FRI
A
Q
S
-
GRPG
P
V
W
I
D
I
P
K
DV
QTAVFEIE
---
TQPAMAEKAAAP-
-
-AFSEE-S
I
RD
A
AAM
I
NA
A
KR
P
V
L
YL
G
G
G
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
TTMT
L
M
A
LG
ML
P
KA
HP
LSL
GM
L
GM
H
G
VRSTNYI
L
Q
E
AD
L
L
IV
L
G
A
RF
DD
R
AIGKTEQ
F
C
P
-
NA
KI
IH
V
DID
R
A
E
L
GKIKQPH
VAI
QA
D
VDDV
L
AQ
L
I
PQ
V
EA----Q
P
R
A
--
-E
W
H
Q
LVADL
Q
REFPCPIP--KAC
D
----------------------------
P
-
LSHYGLINA
V
AA
----
CVDDNAII
T
T
DVG
QH
QM
W
T
A
QA
-
YPLNR
PR
QW
L
T
S
G
--------
GL
G
T
MG
F
GLP
A
AIGA
AL
A
N
P
DRK
V
L
C
FS
GDG
SLM
M
NIQ
E
MA
T
AS
E
NQ
L
D
V
K
I
I
LM
NN
EA
LG
L
V
H
-
QQQS
L
FYEQGVFAATYPGK
-----------
IN
F
MQ
I
A
A
G
F
G
LE
T
CD
L
NNEA
D
PQA
AL
QEIINR
---
PG
P
AL
IHV
R
ID
AE
--------
E
KVY
P
M
V
PP
GA
A
N
T
EM
fig|340186.3.peg.2344
Escherichia coli E110019 (19-559/562)
IV
HF
L
EQQ
G
I
KI
V
T
G
IP
G
GS
I
LP
V
Y
D
A
L
SQS
-
T
Q
I
R
HI
LA
RHEQ
G
A
GFI
A
Q
G
M
A
RTD
GK
P
A
V
--
C
MAC
SGPG
A
TN
L
V
T
AI
A
D
A
RL
D
SI
PLI
C
I
T
G
QVPASM
IG
--
T
D
A
FQE
V
D
TY
--------
GISIPIT
K
HNY
LV
RHI
E
E
LP
QV
M
SD
A
FRI
A
Q
S
-
GRPG
P
V
W
I
D
I
P
K
DV
QTAVFEIE
---
AQPAVAEKAAAP-
-
-AFSEE-S
I
RD
A
ATM
I
NA
A
KR
P
V
L
YL
G
G
G
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
TTMT
L
M
A
LG
ML
P
KA
HP
LSL
GM
L
GM
H
G
VRSTNYI
L
Q
E
AD
L
L
IV
L
G
A
RF
DD
R
AIGKTEQ
F
C
P
-
NA
KI
IH
V
DID
R
A
E
L
GKIKQPH
VAI
QA
D
VDDV
L
AQ
L
I
PQ
V
EA----Q
P
R
A
--
-E
W
H
Q
LVADL
Q
REFPCPIP--KAC
D
----------------------------
P
-
LSHYGLINA
V
AA
----
CVDDNAII
T
T
DVG
QH
QM
W
T
A
QA
-
YPLNR
PR
QW
L
T
S
G
--------
GL
G
T
MG
F
GLP
A
AIGA
AL
A
N
P
DRK
V
L
C
FS
GDG
SLM
M
NIQ
E
MA
T
AS
E
NQ
L
D
V
K
I
I
LM
NN
EA
LG
L
V
H
-
QQQS
L
FYEQGVFAATYPGK
-----------
IN
F
MQ
I
A
A
G
F
G
LE
T
CD
L
NNEA
D
PQA
AL
QEIINR
---
PG
P
AL
IHV
R
ID
AE
--------
E
KVY
P
M
V
PP
GA
A
N
T
EM
fig|340186.5.peg.2421
Escherichia coli E110019 (19-559/562)
IV
HF
L
EQQ
G
I
KI
V
T
G
IP
G
GS
I
LP
V
Y
D
A
L
SQS
-
T
Q
I
R
HI
LA
RHEQ
G
A
GFI
A
Q
G
M
A
RTD
GK
P
A
V
--
C
MAC
SGPG
A
TN
L
V
T
AI
A
D
A
RL
D
SI
PLI
C
I
T
G
QVPASM
IG
--
T
D
A
FQE
V
D
TY
--------
GISIPIT
K
HNY
LV
RHI
E
E
LP
QV
M
SD
A
FRI
A
Q
S
-
GRPG
P
V
W
I
D
I
P
K
DV
QTAVFEIE
---
AQPAVAEKAAAP-
-
-AFSEE-S
I
RD
A
ATM
I
NA
A
KR
P
V
L
YL
G
G
G
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
TTMT
L
M
A
LG
ML
P
KA
HP
LSL
GM
L
GM
H
G
VRSTNYI
L
Q
E
AD
L
L
IV
L
G
A
RF
DD
R
AIGKTEQ
F
C
P
-
NA
KI
IH
V
DID
R
A
E
L
GKIKQPH
VAI
QA
D
VDDV
L
AQ
L
I
PQ
V
EA----Q
P
R
A
--
-E
W
H
Q
LVADL
Q
REFPCPIP--KAC
D
----------------------------
P
-
LSHYGLINA
V
AA
----
CVDDNAII
T
T
DVG
QH
QM
W
T
A
QA
-
YPLNR
PR
QW
L
T
S
G
--------
GL
G
T
MG
F
GLP
A
AIGA
AL
A
N
P
DRK
V
L
C
FS
GDG
SLM
M
NIQ
E
MA
T
AS
E
NQ
L
D
V
K
I
I
LM
NN
EA
LG
L
V
H
-
QQQS
L
FYEQGVFAATYPGK
-----------
IN
F
MQ
I
A
A
G
F
G
LE
T
CD
L
NNEA
D
PQA
AL
QEIINR
---
PG
P
AL
IHV
R
ID
AE
--------
E
KVY
P
M
V
PP
GA
A
N
T
EM
fig|585397.7.peg.4361
Escherichia coli ED1a (19-559/562)
IV
HF
L
EQQ
G
I
KI
V
T
G
IP
G
GS
I
LP
V
Y
D
A
L
SQS
-
T
Q
I
R
HI
LA
RHEQ
G
A
GFI
A
Q
G
M
A
RTD
GK
P
A
V
--
C
MAC
SGPG
A
TN
L
V
T
AI
A
D
A
RL
D
SI
PLI
C
I
T
G
QVPASM
IG
--
T
D
A
FQE
V
D
TY
--------
GISIPIT
K
YNY
LV
RHI
E
E
LP
QV
M
SD
A
FRI
A
Q
S
-
GRPG
P
V
W
I
D
I
P
K
DV
QTAVFEIE
---
TQPAMAEKAAAP-
-
-AFSEE-S
I
RD
A
AAM
I
NA
A
KR
P
V
L
YL
G
G
G
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
TTMT
L
M
A
LG
ML
P
KA
HP
LSL
GM
L
GM
H
G
VRSTNYI
L
Q
E
AD
L
L
IV
L
G
A
RF
DD
R
AIGKTEQ
F
C
P
-
NA
KI
IH
V
DID
R
A
E
L
GKIKQPH
VAI
QA
D
VDDV
L
AQ
L
I
PL
V
EA----Q
P
R
A
--
-E
W
H
Q
LVADL
Q
REFPCPIP--KAC
D
----------------------------
P
-
LSHYGLINA
V
AA
----
CVDDNAII
T
T
DVG
QH
QM
W
T
A
QA
-
YPLNR
PR
QW
L
T
S
G
--------
GL
G
T
MG
F
GLP
A
AIGA
AL
A
N
P
DRK
V
L
C
FS
GDG
SLM
M
NIQ
E
MA
T
AS
E
NQ
L
D
V
K
I
I
LM
NN
EA
LG
L
V
H
-
QQQS
L
FYKQGVFAATYPGK
-----------
IN
F
MQ
I
A
A
G
F
G
LE
T
CD
L
NNEA
D
PQA
AL
QEIINR
---
PG
P
AL
IHV
R
ID
AE
--------
E
KVY
P
M
V
PP
GA
A
N
T
EM
fig|585397.9.peg.4358
Escherichia coli ED1a (19-559/562)
IV
HF
L
EQQ
G
I
KI
V
T
G
IP
G
GS
I
LP
V
Y
D
A
L
SQS
-
T
Q
I
R
HI
LA
RHEQ
G
A
GFI
A
Q
G
M
A
RTD
GK
P
A
V
--
C
MAC
SGPG
A
TN
L
V
T
AI
A
D
A
RL
D
SI
PLI
C
I
T
G
QVPASM
IG
--
T
D
A
FQE
V
D
TY
--------
GISIPIT
K
YNY
LV
RHI
E
E
LP
QV
M
SD
A
FRI
A
Q
S
-
GRPG
P
V
W
I
D
I
P
K
DV
QTAVFEIE
---
TQPAMAEKAAAP-
-
-AFSEE-S
I
RD
A
AAM
I
NA
A
KR
P
V
L
YL
G
G
G
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
TTMT
L
M
A
LG
ML
P
KA
HP
LSL
GM
L
GM
H
G
VRSTNYI
L
Q
E
AD
L
L
IV
L
G
A
RF
DD
R
AIGKTEQ
F
C
P
-
NA
KI
IH
V
DID
R
A
E
L
GKIKQPH
VAI
QA
D
VDDV
L
AQ
L
I
PL
V
EA----Q
P
R
A
--
-E
W
H
Q
LVADL
Q
REFPCPIP--KAC
D
----------------------------
P
-
LSHYGLINA
V
AA
----
CVDDNAII
T
T
DVG
QH
QM
W
T
A
QA
-
YPLNR
PR
QW
L
T
S
G
--------
GL
G
T
MG
F
GLP
A
AIGA
AL
A
N
P
DRK
V
L
C
FS
GDG
SLM
M
NIQ
E
MA
T
AS
E
NQ
L
D
V
K
I
I
LM
NN
EA
LG
L
V
H
-
QQQS
L
FYKQGVFAATYPGK
-----------
IN
F
MQ
I
A
A
G
F
G
LE
T
CD
L
NNEA
D
PQA
AL
QEIINR
---
PG
P
AL
IHV
R
ID
AE
--------
E
KVY
P
M
V
PP
GA
A
N
T
EM
fig|562.376.peg.2506
Escherichia coli WV_060327 (19-559/562)
IV
HF
L
EQQ
G
I
KI
V
T
G
IP
G
GS
I
LP
V
Y
D
A
L
SQS
-
T
Q
I
R
HI
LA
RHEQ
G
A
GFI
A
Q
G
M
A
RTD
GK
P
A
V
--
C
MAC
SGPG
A
TN
L
V
T
AI
A
D
A
RL
D
SI
PLI
C
I
T
G
QVSASM
IG
--
T
D
A
FQE
V
D
TY
--------
GISIPIT
K
HNY
LV
RHI
E
E
L
S
QV
M
SD
A
FRI
A
Q
S
-
GRPG
P
V
W
I
D
I
P
K
DV
QTAVFEIE
---
TQPAMAEKAAAP-
-
-AFSEE-S
I
RD
A
AAM
I
NA
A
KR
P
V
L
YL
G
G
G
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
TTMT
L
M
A
LG
ML
P
KA
HP
LSL
GM
L
GM
H
G
VRSTNYI
L
Q
E
AD
L
L
IV
L
G
A
RF
DD
R
AIGKTEQ
F
C
P
-
NA
KI
IH
V
DID
R
A
E
L
GKIKQPH
VAI
QA
D
VDDV
L
AQ
L
I
PL
V
EA----Q
P
R
A
--
-E
W
H
Q
LVADL
Q
REFPCPIP--KAC
D
----------------------------
P
-
LSHYGLINA
V
AA
----
CVDDNAII
T
T
DVG
QH
QM
W
T
A
QA
-
YPLNR
PR
QW
L
T
S
G
--------
GL
G
T
MG
F
GLP
A
AIGA
AL
A
N
P
DRK
V
L
C
FS
GDG
SLM
M
NIQ
E
MA
T
AS
E
NQ
L
D
V
K
I
I
LM
NN
EA
LG
L
V
H
-
QQQS
L
FYKQGVFAATYPGK
-----------
IN
F
MQ
I
A
A
G
F
G
LE
T
CD
L
NNEA
D
PQA
AL
QEIINR
---
PG
P
AL
IHV
R
ID
AE
--------
E
KVY
P
M
V
PP
GA
A
N
T
EM
fig|749527.3.peg.3417
Escherichia coli MS 21-1 (19-559/562)
IV
HF
L
EQQ
G
I
KI
V
T
G
IP
G
GS
I
LP
V
Y
D
A
L
SQS
-
T
Q
I
R
HI
LA
RHEQ
G
A
GFI
A
Q
G
M
A
RTD
GK
P
A
V
--
C
MAC
SGPG
A
TN
L
V
T
AI
A
D
A
RL
D
SI
PLI
C
I
T
G
QVPASM
IG
--
T
D
A
FQE
V
D
TY
--------
GISIPIT
K
HNY
LV
RHI
E
E
LP
QV
M
SD
A
FRI
A
Q
S
-
GRPG
P
V
W
I
D
I
P
K
DV
QTAVFEIE
---
AQAAMAEKAAAP-
-
-AFSEE-S
I
RD
A
AAM
I
NA
A
KR
P
V
L
YL
G
G
G
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
TTMT
L
M
A
LG
ML
P
KA
HP
LSL
GM
L
GM
H
G
VRSTNYI
L
Q
E
AD
L
L
IV
L
G
A
RF
DD
R
AIGKTEQ
F
C
P
-
NA
KI
IH
V
DID
R
A
E
L
GKIKQPH
VAI
QA
D
VDDV
L
AQ
L
I
PQ
V
EA----Q
P
R
A
--
-E
W
H
Q
LVADL
Q
REFPCPIP--KAC
D
----------------------------
P
-
LSHYGLINA
V
AA
----
CVDDSAII
T
T
DVG
QH
QM
W
T
A
QA
-
YPLNR
PR
QW
L
T
S
G
--------
GL
G
T
MG
F
GLP
A
AIGA
AL
A
N
P
DRK
V
L
C
FS
GDG
SLM
M
NIQ
E
MA
T
AS
E
NQ
L
D
V
K
I
I
LM
NN
EA
LG
L
V
H
-
QQQS
L
FYKQGVFAATYPGK
-----------
IN
F
MQ
I
A
A
G
F
G
LE
T
CD
L
NNET
D
PQA
AL
QEIINR
---
PG
P
AL
IHV
R
ID
AE
--------
E
KVY
P
M
V
PP
GA
A
N
T
EM
fig|573235.3.peg.5058
Escherichia coli O26:H11 str. 11368 (19-559/562)
IV
HF
L
EQQ
G
I
KI
V
T
G
IP
G
GS
I
LP
V
Y
D
A
L
SQS
-
T
Q
I
R
HI
LA
RHEQ
G
A
GFI
A
Q
G
M
A
RTD
GK
P
A
V
--
C
MAC
SGPG
A
TN
L
V
T
AI
A
D
A
RL
D
SI
PLI
C
I
T
G
QVPASM
IG
--
T
D
V
FQE
V
D
TY
--------
GISIPIT
K
HNY
LV
RHI
E
E
LP
QV
M
SD
A
FRI
A
Q
S
-
GRPG
P
V
W
I
D
I
P
K
DV
QTAVFEIE
---
TQPAMAEKAAAP-
-
-AFSEE-S
I
RD
A
AAM
I
NA
A
KR
P
V
L
YL
G
G
G
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
TTMT
L
M
A
LG
ML
P
KA
HP
LSL
GM
L
GM
H
G
VRSTNYI
L
Q
E
AD
L
L
IV
L
G
A
RF
DD
R
AIGKTEQ
F
C
P
-
NA
KI
IH
V
DID
R
A
E
L
GKIKQPH
VAI
QA
D
VDDV
L
AQ
L
I
PQ
V
EA----Q
P
R
A
--
-E
W
H
Q
LVADL
Q
REFPCPIP--KAC
D
----------------------------
P
-
LSHYGLINA
V
AA
----
CVDDNAII
T
T
DVG
QH
QM
W
T
A
QA
-
YPLNR
PR
QW
L
T
S
G
--------
GL
G
T
MG
F
GLP
A
AIGA
AL
A
N
P
DRK
V
L
C
FS
GDG
SLM
M
NIQ
E
MA
T
AS
E
NQ
L
D
V
K
I
I
LM
NN
EA
LG
L
V
H
-
QQQS
L
FYEQGVFAATYPGK
-----------
IN
F
MQ
I
A
A
G
F
G
LE
T
CD
L
NNEA
D
PQA
AL
QEIINR
---
PG
P
AL
IHV
R
ID
AE
--------
E
KVY
P
M
V
PP
GA
A
N
T
EM
fig|656414.3.peg.1077
Escherichia coli H736 (9-539/572)
I
A
KT
L
ESA
GV
KR
I
W
G
VT
G
DS
L
NG
L
S
D
S
L
NRM
-
G
T
I
E
W
M
ST
RHE
E
V
A
AFA
A
G
A
E
A
QLS
G
E
L
A
V
--
C
AGS
C
GPG
N
LH
L
I
N
GL
F
D
C
HR
N
HV
P
VL
A
I
A
A
HIPSSE
IG
--
S
G
Y
FQE
T
H
PQ
--------
ELFRECS
H
YCE
LV
SSP
E
Q
I
P
QV
L
AI
A
MRK
A
V
L
-
N
R
-
G
V
S
V
V
V
LP
G
DV
ALKPA---
---
PEGATMHWYHAPQ
P
VVTPEEEE
L
RK
L
AQL
L
RY
S
SN
I
A
L
MC
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
IVHA
L
R
G
KE
HV
E
YD
N
P
YDV
GM
T
G
L
I
G
FSSGFHT
M
M
NAD
T
L
VL
L
G
T
Q
F
PY
R
A------
F
Y
P
T
D
A
KI
I
Q
IDI
N
P
A
S
I
GAHSKVD
M
A
L
VGD
IKST
L
RA
LL
PL
V
EEKADRK
F
L
D
--
--
-
-
K
ALEDY
R
DARKGLDDLAKPS
E
----------------------------
K
A
IHPQYLAQQ
I
SH
----
FAADDAIF
T
C
DVG
TP
T
V
W
AA
RY
-
LKMNG
K
R
RL
L
G
S
F
--------
NH
G
S
M
A
N
AM
P
Q
A
L
GA
QA
T
E
P
ERQ
VV
A
MC
GDG
GFS
M
LMG
D
FL
S
VV
Q
MK
LPV
K
IV
VF
NN
SV
LG
F
V
A
-
--ME
M
KAGGYLTDGTKLHD
-----------
TN
F
AR
I
A
E
A
C
G
IT
G
IR
V
EKAS
E
VDE
AL
QRAFSI
---
DG
P
VL
V
D
V
V
VA
KE
--------
E
LAI
P
P
Q
IK
fig|749540.3.peg.2813
Escherichia coli MS 146-1 (9-539/572)
I
A
KT
L
ESA
GV
KR
I
W
G
VT
G
DS
L
NG
L
S
D
S
L
NRM
-
G
T
I
E
W
M
ST
RHE
E
V
A
AFA
A
G
A
E
A
QLS
G
E
L
A
V
--
C
AGS
C
GPG
N
LH
L
I
N
GL
F
D
C
HR
N
HV
P
VL
A
I
A
A
HIPSSE
IG
--
S
G
Y
FQE
T
H
PQ
--------
ELFRECS
H
YCE
LV
SSP
E
Q
I
P
QV
L
AI
A
MRK
A
V
L
-
N
R
-
G
V
S
V
V
V
LP
G
DV
ALKPA---
---
PEGATMHWYHAPQ
P
VVTPEEEE
L
RK
L
AQL
L
RY
S
SN
I
A
L
MC
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
IVHA
L
R
G
KE
HV
E
YD
N
P
YDV
GM
T
G
L
I
G
FSSGFHT
M
M
NAD
T
L
VL
L
G
T
Q
F
PY
R
A------
F
Y
P
T
D
A
KI
I
Q
IDI
N
P
A
S
I
GAHSKVD
M
A
L
VGD
IKST
L
RA
LL
PL
V
EEKADRK
F
L
D
--
--
-
-
K
ALEDY
R
DARKGLDDLAKPS
E
----------------------------
K
A
IHPQYLAQQ
I
SH
----
FAADDAIF
T
C
DVG
TP
T
V
W
AA
RY
-
LKMNG
K
R
RL
L
G
S
F
--------
NH
G
S
M
A
N
AM
P
Q
A
L
GA
QA
T
E
P
ERQ
VV
A
MC
GDG
GFS
M
LMG
D
FL
S
VV
Q
MK
LPV
K
IV
VF
NN
SV
LG
F
V
A
-
--ME
M
KAGGYLTDGTKLHD
-----------
TN
F
AR
I
A
E
A
C
G
IT
G
IR
V
EKAS
E
VDE
AL
QRAFSI
---
DG
P
VL
V
D
V
V
VA
KE
--------
E
LAI
P
P
Q
IK
fig|670888.3.peg.1484
Escherichia coli 1827-70 (9-539/572)
I
A
KT
L
ESA
GV
KR
I
W
G
VT
G
DS
L
NG
L
S
D
S
L
NRM
-
G
T
I
E
W
M
ST
RHE
E
V
A
AFA
A
G
A
E
A
QLS
G
E
L
A
V
--
C
AGS
C
GPG
N
LH
L
I
N
GL
F
D
C
HR
N
HV
P
VL
A
I
A
A
HIPSSE
IG
--
S
G
Y
FQE
T
H
PQ
--------
ELFRECS
H
YCE
LV
SSP
E
Q
I
P
QV
L
AI
A
MRK
A
V
L
-
N
R
-
G
V
S
V
V
V
LP
G
DV
ALKPA---
---
PEGATMHWYHAPQ
P
VVTPEEEE
L
RK
L
AQL
L
RY
S
SN
I
A
L
MC
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
IVHA
L
R
G
KE
HV
E
YD
N
P
YDV
GM
T
G
L
I
G
FSSGFHT
M
M
NAD
T
L
VL
L
G
T
Q
F
PY
R
A------
F
Y
P
T
D
A
KI
I
Q
IDI
N
P
A
S
I
GAHSKVD
M
A
L
VGD
IKST
L
RA
LL
PL
V
EEKADRK
F
L
D
--
--
-
-
K
ALEDY
R
DARKGLDDLAKPS
E
----------------------------
K
A
IHPQYLAQQ
I
SH
----
FAADDAIF
T
C
DVG
TP
T
V
W
AA
RY
-
LKMNG
K
R
RL
L
G
S
F
--------
NH
G
S
M
A
N
AM
P
Q
A
L
GA
QA
T
E
P
ERQ
VV
A
MC
GDG
GFS
M
LMG
D
FL
S
VV
Q
MK
LPV
K
IV
VF
NN
SV
LG
F
V
A
-
--ME
M
KAGGYLTDGTELHD
-----------
TN
F
AR
I
A
E
A
C
G
IT
G
IR
V
EKAS
E
VDE
AL
QRAFSI
---
DG
P
VL
V
D
V
V
VA
KE
--------
E
LAI
P
P
Q
IK
fig|481805.3.peg.2929
Escherichia coli ATCC 8739 (9-539/572)
I
A
KT
L
ESA
GV
KR
I
W
G
VT
G
DS
L
NG
L
S
D
S
L
NRM
-
G
T
I
E
W
M
ST
RHE
E
V
A
AFA
A
G
A
E
A
QLS
G
E
L
A
V
--
C
AGS
C
GPG
N
LH
L
I
N
GL
F
D
C
HR
N
HV
P
VL
A
I
A
A
HIPSSE
IG
--
S
G
Y
FQE
T
H
PQ
--------
ELFRECS
H
YCE
LV
SSP
E
Q
I
P
QV
L
AI
A
MRK
A
V
L
-
N
R
-
G
V
S
V
V
V
LP
G
DV
ALKPA---
---
PEGATMHWYHAPQ
P
VVTPEEEE
L
RK
L
AQL
L
RY
S
SN
I
A
L
MC
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
IVHA
L
R
G
KE
HV
E
YD
N
P
YDV
GM
T
G
L
I
G
FSSGFHT
M
M
NAD
T
L
VL
L
G
T
Q
F
PY
R
A------
F
Y
P
T
D
A
KI
I
Q
IDI
N
P
A
S
I
GAHSKVD
M
A
L
VGD
IKST
L
RA
LL
PL
V
EEKADRK
F
L
D
--
--
-
-
K
ALEDY
R
DARKGLDDLAKPS
E
----------------------------
K
A
IHPQYLAQQ
I
SH
----
FAADDAIF
T
C
DVG
TP
T
V
W
AA
RY
-
LKMNG
K
R
RL
L
G
S
F
--------
NH
G
S
M
A
N
AM
P
Q
A
L
GA
QA
T
E
P
ERQ
VV
A
MC
GDG
GFS
M
LMG
D
FL
S
VV
Q
MK
LPV
K
IV
VF
NN
SV
LG
F
V
A
-
--ME
M
KAGGYLTDGTELHD
-----------
TN
F
AR
I
A
E
A
C
G
IT
G
IR
V
EKAS
E
VDE
AL
QRAFSI
---
DG
P
VL
V
D
V
V
VA
KE
--------
E
LAI
P
P
Q
IK
fig|481805.6.peg.2919
Escherichia coli ATCC 8739 (9-539/572)
I
A
KT
L
ESA
GV
KR
I
W
G
VT
G
DS
L
NG
L
S
D
S
L
NRM
-
G
T
I
E
W
M
ST
RHE
E
V
A
AFA
A
G
A
E
A
QLS
G
E
L
A
V
--
C
AGS
C
GPG
N
LH
L
I
N
GL
F
D
C
HR
N
HV
P
VL
A
I
A
A
HIPSSE
IG
--
S
G
Y
FQE
T
H
PQ
--------
ELFRECS
H
YCE
LV
SSP
E
Q
I
P
QV
L
AI
A
MRK
A
V
L
-
N
R
-
G
V
S
V
V
V
LP
G
DV
ALKPA---
---
PEGATMHWYHAPQ
P
VVTPEEEE
L
RK
L
AQL
L
RY
S
SN
I
A
L
MC
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
IVHA
L
R
G
KE
HV
E
YD
N
P
YDV
GM
T
G
L
I
G
FSSGFHT
M
M
NAD
T
L
VL
L
G
T
Q
F
PY
R
A------
F
Y
P
T
D
A
KI
I
Q
IDI
N
P
A
S
I
GAHSKVD
M
A
L
VGD
IKST
L
RA
LL
PL
V
EEKADRK
F
L
D
--
--
-
-
K
ALEDY
R
DARKGLDDLAKPS
E
----------------------------
K
A
IHPQYLAQQ
I
SH
----
FAADDAIF
T
C
DVG
TP
T
V
W
AA
RY
-
LKMNG
K
R
RL
L
G
S
F
--------
NH
G
S
M
A
N
AM
P
Q
A
L
GA
QA
T
E
P
ERQ
VV
A
MC
GDG
GFS
M
LMG
D
FL
S
VV
Q
MK
LPV
K
IV
VF
NN
SV
LG
F
V
A
-
--ME
M
KAGGYLTDGTELHD
-----------
TN
F
AR
I
A
E
A
C
G
IT
G
IR
V
EKAS
E
VDE
AL
QRAFSI
---
DG
P
VL
V
D
V
V
VA
KE
--------
E
LAI
P
P
Q
IK
fig|595496.3.peg.798
Escherichia coli BW2952 (9-539/572)
I
A
KT
L
ESA
GV
KR
I
W
G
VT
G
DS
L
NG
L
S
D
S
L
NRM
-
G
T
I
E
W
M
ST
RHE
E
V
A
AFA
A
G
A
E
A
QLS
G
E
L
A
V
--
C
AGS
C
GPG
N
LH
L
I
N
GL
F
D
C
HR
N
HV
P
VL
A
I
A
A
HIPSSE
IG
--
S
G
Y
FQE
T
H
PQ
--------
ELFRECS
H
YCE
LV
SSP
E
Q
I
P
QV
L
AI
A
MRK
A
V
L
-
N
R
-
G
V
S
V
V
V
LP
G
DV
ALKPA---
---
PEGATMHWYHAPQ
P
VVTPEEEE
L
RK
L
AQL
L
RY
S
SN
I
A
L
MC
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
IVHA
L
R
G
KE
HV
E
YD
N
P
YDV
GM
T
G
L
I
G
FSSGFHT
M
M
NAD
T
L
VL
L
G
T
Q
F
PY
R
A------
F
Y
P
T
D
A
KI
I
Q
IDI
N
P
A
S
I
GAHSKVD
M
A
L
VGD
IKST
L
RA
LL
PL
V
EEKADRK
F
L
D
--
--
-
-
K
ALEDY
R
DARKGLDDLAKPS
E
----------------------------
K
A
IHPQYLAQQ
I
SH
----
FAADDAIF
T
C
DVG
TP
T
V
W
AA
RY
-
LKMNG
K
R
RL
L
G
S
F
--------
NH
G
S
M
A
N
AM
P
Q
A
L
GA
QA
T
E
P
ERQ
VV
A
MC
GDG
GFS
M
LMG
D
FL
S
VV
Q
MK
LPV
K
IV
VF
NN
SV
LG
F
V
A
-
--ME
M
KAGGYLTDGTELHD
-----------
TN
F
AR
I
A
E
A
C
G
IT
G
IR
V
EKAS
E
VDE
AL
QRAFSI
---
DG
P
VL
V
D
V
V
VA
KE
--------
E
LAI
P
P
Q
IK
fig|536056.3.peg.2925
Escherichia coli DH1 (9-539/572)
I
A
KT
L
ESA
GV
KR
I
W
G
VT
G
DS
L
NG
L
S
D
S
L
NRM
-
G
T
I
E
W
M
ST
RHE
E
V
A
AFA
A
G
A
E
A
QLS
G
E
L
A
V
--
C
AGS
C
GPG
N
LH
L
I
N
GL
F
D
C
HR
N
HV
P
VL
A
I
A
A
HIPSSE
IG
--
S
G
Y
FQE
T
H
PQ
--------
ELFRECS
H
YCE
LV
SSP
E
Q
I
P
QV
L
AI
A
MRK
A
V
L
-
N
R
-
G
V
S
V
V
V
LP
G
DV
ALKPA---
---
PEGATMHWYHAPQ
P
VVTPEEEE
L
RK
L
AQL
L
RY
S
SN
I
A
L
MC
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
IVHA
L
R
G
KE
HV
E
YD
N
P
YDV
GM
T
G
L
I
G
FSSGFHT
M
M
NAD
T
L
VL
L
G
T
Q
F
PY
R
A------
F
Y
P
T
D
A
KI
I
Q
IDI
N
P
A
S
I
GAHSKVD
M
A
L
VGD
IKST
L
RA
LL
PL
V
EEKADRK
F
L
D
--
--
-
-
K
ALEDY
R
DARKGLDDLAKPS
E
----------------------------
K
A
IHPQYLAQQ
I
SH
----
FAADDAIF
T
C
DVG
TP
T
V
W
AA
RY
-
LKMNG
K
R
RL
L
G
S
F
--------
NH
G
S
M
A
N
AM
P
Q
A
L
GA
QA
T
E
P
ERQ
VV
A
MC
GDG
GFS
M
LMG
D
FL
S
VV
Q
MK
LPV
K
IV
VF
NN
SV
LG
F
V
A
-
--ME
M
KAGGYLTDGTELHD
-----------
TN
F
AR
I
A
E
A
C
G
IT
G
IR
V
EKAS
E
VDE
AL
QRAFSI
---
DG
P
VL
V
D
V
V
VA
KE
--------
E
LAI
P
P
Q
IK
fig|83333.1.peg.857
Escherichia coli K12 (9-539/572)
I
A
KT
L
ESA
GV
KR
I
W
G
VT
G
DS
L
NG
L
S
D
S
L
NRM
-
G
T
I
E
W
M
ST
RHE
E
V
A
AFA
A
G
A
E
A
QLS
G
E
L
A
V
--
C
AGS
C
GPG
N
LH
L
I
N
GL
F
D
C
HR
N
HV
P
VL
A
I
A
A
HIPSSE
IG
--
S
G
Y
FQE
T
H
PQ
--------
ELFRECS
H
YCE
LV
SSP
E
Q
I
P
QV
L
AI
A
MRK
A
V
L
-
N
R
-
G
V
S
V
V
V
LP
G
DV
ALKPA---
---
PEGATMHWYHAPQ
P
VVTPEEEE
L
RK
L
AQL
L
RY
S
SN
I
A
L
MC
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
IVHA
L
R
G
KE
HV
E
YD
N
P
YDV
GM
T
G
L
I
G
FSSGFHT
M
M
NAD
T
L
VL
L
G
T
Q
F
PY
R
A------
F
Y
P
T
D
A
KI
I
Q
IDI
N
P
A
S
I
GAHSKVD
M
A
L
VGD
IKST
L
RA
LL
PL
V
EEKADRK
F
L
D
--
--
-
-
K
ALEDY
R
DARKGLDDLAKPS
E
----------------------------
K
A
IHPQYLAQQ
I
SH
----
FAADDAIF
T
C
DVG
TP
T
V
W
AA
RY
-
LKMNG
K
R
RL
L
G
S
F
--------
NH
G
S
M
A
N
AM
P
Q
A
L
GA
QA
T
E
P
ERQ
VV
A
MC
GDG
GFS
M
LMG
D
FL
S
VV
Q
MK
LPV
K
IV
VF
NN
SV
LG
F
V
A
-
--ME
M
KAGGYLTDGTELHD
-----------
TN
F
AR
I
A
E
A
C
G
IT
G
IR
V
EKAS
E
VDE
AL
QRAFSI
---
DG
P
VL
V
D
V
V
VA
KE
--------
E
LAI
P
P
Q
IK
fig|749538.3.peg.612
Escherichia coli MS 116-1 (9-539/572)
I
A
KT
L
ESA
GV
KR
I
W
G
VT
G
DS
L
NG
L
S
D
S
L
NRM
-
G
T
I
E
W
M
ST
RHE
E
V
A
AFA
A
G
A
E
A
QLS
G
E
L
A
V
--
C
AGS
C
GPG
N
LH
L
I
N
GL
F
D
C
HR
N
HV
P
VL
A
I
A
A
HIPSSE
IG
--
S
G
Y
FQE
T
H
PQ
--------
ELFRECS
H
YCE
LV
SSP
E
Q
I
P
QV
L
AI
A
MRK
A
V
L
-
N
R
-
G
V
S
V
V
V
LP
G
DV
ALKPA---
---
PEGATMHWYHAPQ
P
VVTPEEEE
L
RK
L
AQL
L
RY
S
SN
I
A
L
MC
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
IVHA
L
R
G
KE
HV
E
YD
N
P
YDV
GM
T
G
L
I
G
FSSGFHT
M
M
NAD
T
L
VL
L
G
T
Q
F
PY
R
A------
F
Y
P
T
D
A
KI
I
Q
IDI
N
P
A
S
I
GAHSKVD
M
A
L
VGD
IKST
L
RA
LL
PL
V
EEKADRK
F
L
D
--
--
-
-
K
ALEDY
R
DARKGLDDLAKPS
E
----------------------------
K
A
IHPQYLAQQ
I
SH
----
FAADDAIF
T
C
DVG
TP
T
V
W
AA
RY
-
LKMNG
K
R
RL
L
G
S
F
--------
NH
G
S
M
A
N
AM
P
Q
A
L
GA
QA
T
E
P
ERQ
VV
A
MC
GDG
GFS
M
LMG
D
FL
S
VV
Q
MK
LPV
K
IV
VF
NN
SV
LG
F
V
A
-
--ME
M
KAGGYLTDGTELHD
-----------
TN
F
AR
I
A
E
A
C
G
IT
G
IR
V
EKAS
E
VDE
AL
QRAFSI
---
DG
P
VL
V
D
V
V
VA
KE
--------
E
LAI
P
P
Q
IK
fig|749544.3.peg.2759
Escherichia coli MS 175-1 (9-539/572)
I
A
KT
L
ESA
GV
KR
I
W
G
VT
G
DS
L
NG
L
S
D
S
L
NRM
-
G
T
I
E
W
M
ST
RHE
E
V
A
AFA
A
G
A
E
A
QLS
G
E
L
A
V
--
C
AGS
C
GPG
N
LH
L
I
N
GL
F
D
C
HR
N
HV
P
VL
A
I
A
A
HIPSSE
IG
--
S
G
Y
FQE
T
H
PQ
--------
ELFRECS
H
YCE
LV
SSP
E
Q
I
P
QV
L
AI
A
MRK
A
V
L
-
N
R
-
G
V
S
V
V
V
LP
G
DV
ALKPA---
---
PEGATMHWYHAPQ
P
VVTPEEEE
L
RK
L
AQL
L
RY
S
SN
I
A
L
MC
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
IVHA
L
R
G
KE
HV
E
YD
N
P
YDV
GM
T
G
L
I
G
FSSGFHT
M
M
NAD
T
L
VL
L
G
T
Q
F
PY
R
A------
F
Y
P
T
D
A
KI
I
Q
IDI
N
P
A
S
I
GAHSKVD
M
A
L
VGD
IKST
L
RA
LL
PL
V
EEKADRK
F
L
D
--
--
-
-
K
ALEDY
R
DARKGLDDLAKPS
E
----------------------------
K
A
IHPQYLAQQ
I
SH
----
FAADDAIF
T
C
DVG
TP
T
V
W
AA
RY
-
LKMNG
K
R
RL
L
G
S
F
--------
NH
G
S
M
A
N
AM
P
Q
A
L
GA
QA
T
E
P
ERQ
VV
A
MC
GDG
GFS
M
LMG
D
FL
S
VV
Q
MK
LPV
K
IV
VF
NN
SV
LG
F
V
A
-
--ME
M
KAGGYLTDGTELHD
-----------
TN
F
AR
I
A
E
A
C
G
IT
G
IR
V
EKAS
E
VDE
AL
QRAFSI
---
DG
P
VL
V
D
V
V
VA
KE
--------
E
LAI
P
P
Q
IK
fig|749548.3.peg.3363
Escherichia coli MS 196-1 (9-539/572)
I
A
KT
L
ESA
GV
KR
I
W
G
VT
G
DS
L
NG
L
S
D
S
L
NRM
-
G
T
I
E
W
M
ST
RHE
E
V
A
AFA
A
G
A
E
A
QLS
G
E
L
A
V
--
C
AGS
C
GPG
N
LH
L
I
N
GL
F
D
C
HR
N
HV
P
VL
A
I
A
A
HIPSSE
IG
--
S
G
Y
FQE
T
H
PQ
--------
ELFRECS
H
YCE
LV
SSP
E
Q
I
P
QV
L
AI
A
MRK
A
V
L
-
N
R
-
G
V
S
V
V
V
LP
G
DV
ALKPA---
---
PEGATMHWYHAPQ
P
VVTPEEEE
L
RK
L
AQL
L
RY
S
SN
I
A
L
MC
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
IVHA
L
R
G
KE
HV
E
YD
N
P
YDV
GM
T
G
L
I
G
FSSGFHT
M
M
NAD
T
L
VL
L
G
T
Q
F
PY
R
A------
F
Y
P
T
D
A
KI
I
Q
IDI
N
P
A
S
I
GAHSKVD
M
A
L
VGD
IKST
L
RA
LL
PL
V
EEKADRK
F
L
D
--
--
-
-
K
ALEDY
R
DARKGLDDLAKPS
E
----------------------------
K
A
IHPQYLAQQ
I
SH
----
FAADDAIF
T
C
DVG
TP
T
V
W
AA
RY
-
LKMNG
K
R
RL
L
G
S
F
--------
NH
G
S
M
A
N
AM
P
Q
A
L
GA
QA
T
E
P
ERQ
VV
A
MC
GDG
GFS
M
LMG
D
FL
S
VV
Q
MK
LPV
K
IV
VF
NN
SV
LG
F
V
A
-
--ME
M
KAGGYLTDGTELHD
-----------
TN
F
AR
I
A
E
A
C
G
IT
G
IR
V
EKAS
E
VDE
AL
QRAFSI
---
DG
P
VL
V
D
V
V
VA
KE
--------
E
LAI
P
P
Q
IK
fig|316407.3.peg.838
Escherichia coli W3110 (9-539/572)
I
A
KT
L
ESA
GV
KR
I
W
G
VT
G
DS
L
NG
L
S
D
S
L
NRM
-
G
T
I
E
W
M
ST
RHE
E
V
A
AFA
A
G
A
E
A
QLS
G
E
L
A
V
--
C
AGS
C
GPG
N
LH
L
I
N
GL
F
D
C
HR
N
HV
P
VL
A
I
A
A
HIPSSE
IG
--
S
G
Y
FQE
T
H
PQ
--------
ELFRECS
H
YCE
LV
SSP
E
Q
I
P
QV
L
AI
A
MRK
A
V
L
-
N
R
-
G
V
S
V
V
V
LP
G
DV
ALKPA---
---
PEGATMHWYHAPQ
P
VVTPEEEE
L
RK
L
AQL
L
RY
S
SN
I
A
L
MC
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
IVHA
L
R
G
KE
HV
E
YD
N
P
YDV
GM
T
G
L
I
G
FSSGFHT
M
M
NAD
T
L
VL
L
G
T
Q
F
PY
R
A------
F
Y
P
T
D
A
KI
I
Q
IDI
N
P
A
S
I
GAHSKVD
M
A
L
VGD
IKST
L
RA
LL
PL
V
EEKADRK
F
L
D
--
--
-
-
K
ALEDY
R
DARKGLDDLAKPS
E
----------------------------
K
A
IHPQYLAQQ
I
SH
----
FAADDAIF
T
C
DVG
TP
T
V
W
AA
RY
-
LKMNG
K
R
RL
L
G
S
F
--------
NH
G
S
M
A
N
AM
P
Q
A
L
GA
QA
T
E
P
ERQ
VV
A
MC
GDG
GFS
M
LMG
D
FL
S
VV
Q
MK
LPV
K
IV
VF
NN
SV
LG
F
V
A
-
--ME
M
KAGGYLTDGTELHD
-----------
TN
F
AR
I
A
E
A
C
G
IT
G
IR
V
EKAS
E
VDE
AL
QRAFSI
---
DG
P
VL
V
D
V
V
VA
KE
--------
E
LAI
P
P
Q
IK
fig|316385.7.peg.951
Escherichia coli str. K-12 substr. DH10B (9-539/572)
I
A
KT
L
ESA
GV
KR
I
W
G
VT
G
DS
L
NG
L
S
D
S
L
NRM
-
G
T
I
E
W
M
ST
RHE
E
V
A
AFA
A
G
A
E
A
QLS
G
E
L
A
V
--
C
AGS
C
GPG
N
LH
L
I
N
GL
F
D
C
HR
N
HV
P
VL
A
I
A
A
HIPSSE
IG
--
S
G
Y
FQE
T
H
PQ
--------
ELFRECS
H
YCE
LV
SSP
E
Q
I
P
QV
L
AI
A
MRK
A
V
L
-
N
R
-
G
V
S
V
V
V
LP
G
DV
ALKPA---
---
PEGATMHWYHAPQ
P
VVTPEEEE
L
RK
L
AQL
L
RY
S
SN
I
A
L
MC
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
IVHA
L
R
G
KE
HV
E
YD
N
P
YDV
GM
T
G
L
I
G
FSSGFHT
M
M
NAD
T
L
VL
L
G
T
Q
F
PY
R
A------
F
Y
P
T
D
A
KI
I
Q
IDI
N
P
A
S
I
GAHSKVD
M
A
L
VGD
IKST
L
RA
LL
PL
V
EEKADRK
F
L
D
--
--
-
-
K
ALEDY
R
DARKGLDDLAKPS
E
----------------------------
K
A
IHPQYLAQQ
I
SH
----
FAADDAIF
T
C
DVG
TP
T
V
W
AA
RY
-
LKMNG
K
R
RL
L
G
S
F
--------
NH
G
S
M
A
N
AM
P
Q
A
L
GA
QA
T
E
P
ERQ
VV
A
MC
GDG
GFS
M
LMG
D
FL
S
VV
Q
MK
LPV
K
IV
VF
NN
SV
LG
F
V
A
-
--ME
M
KAGGYLTDGTELHD
-----------
TN
F
AR
I
A
E
A
C
G
IT
G
IR
V
EKAS
E
VDE
AL
QRAFSI
---
DG
P
VL
V
D
V
V
VA
KE
--------
E
LAI
P
P
Q
IK
fig|511145.12.peg.900
Escherichia coli str. K-12 substr. MG1655 (9-539/572)
I
A
KT
L
ESA
GV
KR
I
W
G
VT
G
DS
L
NG
L
S
D
S
L
NRM
-
G
T
I
E
W
M
ST
RHE
E
V
A
AFA
A
G
A
E
A
QLS
G
E
L
A
V
--
C
AGS
C
GPG
N
LH
L
I
N
GL
F
D
C
HR
N
HV
P
VL
A
I
A
A
HIPSSE
IG
--
S
G
Y
FQE
T
H
PQ
--------
ELFRECS
H
YCE
LV
SSP
E
Q
I
P
QV
L
AI
A
MRK
A
V
L
-
N
R
-
G
V
S
V
V
V
LP
G
DV
ALKPA---
---
PEGATMHWYHAPQ
P
VVTPEEEE
L
RK
L
AQL
L
RY
S
SN
I
A
L
MC
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
IVHA
L
R
G
KE
HV
E
YD
N
P
YDV
GM
T
G
L
I
G
FSSGFHT
M
M
NAD
T
L
VL
L
G
T
Q
F
PY
R
A------
F
Y
P
T
D
A
KI
I
Q
IDI
N
P
A
S
I
GAHSKVD
M
A
L
VGD
IKST
L
RA
LL
PL
V
EEKADRK
F
L
D
--
--
-
-
K
ALEDY
R
DARKGLDDLAKPS
E
----------------------------
K
A
IHPQYLAQQ
I
SH
----
FAADDAIF
T
C
DVG
TP
T
V
W
AA
RY
-
LKMNG
K
R
RL
L
G
S
F
--------
NH
G
S
M
A
N
AM
P
Q
A
L
GA
QA
T
E
P
ERQ
VV
A
MC
GDG
GFS
M
LMG
D
FL
S
VV
Q
MK
LPV
K
IV
VF
NN
SV
LG
F
V
A
-
--ME
M
KAGGYLTDGTELHD
-----------
TN
F
AR
I
A
E
A
C
G
IT
G
IR
V
EKAS
E
VDE
AL
QRAFSI
---
DG
P
VL
V
D
V
V
VA
KE
--------
E
LAI
P
P
Q
IK
fig|511145.6.peg.893
Escherichia coli str. K-12 substr. MG1655 (9-539/572)
I
A
KT
L
ESA
GV
KR
I
W
G
VT
G
DS
L
NG
L
S
D
S
L
NRM
-
G
T
I
E
W
M
ST
RHE
E
V
A
AFA
A
G
A
E
A
QLS
G
E
L
A
V
--
C
AGS
C
GPG
N
LH
L
I
N
GL
F
D
C
HR
N
HV
P
VL
A
I
A
A
HIPSSE
IG
--
S
G
Y
FQE
T
H
PQ
--------
ELFRECS
H
YCE
LV
SSP
E
Q
I
P
QV
L
AI
A
MRK
A
V
L
-
N
R
-
G
V
S
V
V
V
LP
G
DV
ALKPA---
---
PEGATMHWYHAPQ
P
VVTPEEEE
L
RK
L
AQL
L
RY
S
SN
I
A
L
MC
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
IVHA
L
R
G
KE
HV
E
YD
N
P
YDV
GM
T
G
L
I
G
FSSGFHT
M
M
NAD
T
L
VL
L
G
T
Q
F
PY
R
A------
F
Y
P
T
D
A
KI
I
Q
IDI
N
P
A
S
I
GAHSKVD
M
A
L
VGD
IKST
L
RA
LL
PL
V
EEKADRK
F
L
D
--
--
-
-
K
ALEDY
R
DARKGLDDLAKPS
E
----------------------------
K
A
IHPQYLAQQ
I
SH
----
FAADDAIF
T
C
DVG
TP
T
V
W
AA
RY
-
LKMNG
K
R
RL
L
G
S
F
--------
NH
G
S
M
A
N
AM
P
Q
A
L
GA
QA
T
E
P
ERQ
VV
A
MC
GDG
GFS
M
LMG
D
FL
S
VV
Q
MK
LPV
K
IV
VF
NN
SV
LG
F
V
A
-
--ME
M
KAGGYLTDGTELHD
-----------
TN
F
AR
I
A
E
A
C
G
IT
G
IR
V
EKAS
E
VDE
AL
QRAFSI
---
DG
P
VL
V
D
V
V
VA
KE
--------
E
LAI
P
P
Q
IK
fig|358709.5.peg.3171
Escherichia coli 101-1 (9-539/572)
I
A
KT
L
ESA
GV
KR
I
W
G
VT
G
DS
L
NG
L
S
D
S
L
NRM
-
G
T
I
E
W
M
ST
RHE
E
V
A
AFA
A
G
A
E
A
QLS
G
E
L
A
V
--
C
AGS
C
GPG
N
LH
L
I
N
GL
F
D
C
HR
N
HV
P
VL
A
I
A
A
HIPSSE
IG
--
S
G
Y
FQE
T
H
PQ
--------
ELFRECS
H
YCE
LV
SSP
E
Q
I
P
QV
L
AI
A
MRK
A
V
L
-
N
R
-
G
V
S
I
V
V
LP
G
DV
ALKPA---
---
PEGATMHWYHAPQ
P
VVTPEEEE
L
RK
L
AQL
L
RY
S
SN
I
A
L
MC
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
IVHA
L
R
G
KE
HV
E
YD
N
P
YDV
GM
T
G
L
I
G
FSSGFHT
M
M
NAD
T
L
VL
L
G
T
Q
F
PY
R
A------
F
Y
P
T
D
A
KI
I
Q
IDI
N
P
A
S
I
GAHSKVD
M
A
L
VGD
IKST
L
RA
LL
PL
V
EEKADRK
F
L
D
--
--
-
-
K
ALEDY
R
DARKGLDDLAKPS
E
----------------------------
K
A
IHPQYLAQQ
I
SH
----
FAADDAIF
T
C
DVG
TP
T
V
W
AA
RY
-
LKMNG
K
R
RL
L
G
S
F
--------
NH
G
S
M
A
N
AM
P
Q
A
L
GA
QA
T
E
P
ERQ
VV
A
MC
GDG
GFS
M
LMG
D
FL
S
VV
Q
MK
LPV
K
IV
VF
NN
SV
LG
F
V
A
-
--ME
M
KAGGYLTDGTELHD
-----------
TN
F
AR
I
A
E
A
C
G
IT
G
IR
V
EKAS
E
VDE
AL
QRAFSI
---
DG
P
VL
V
D
V
V
VA
KE
--------
E
LAI
P
P
Q
IK
fig|344610.3.peg.3310
Escherichia coli 53638 (9-539/572)
I
A
KT
L
ESA
GV
KR
I
W
G
VT
G
DS
L
NG
L
S
D
S
L
NRM
-
G
T
I
E
W
M
ST
RHE
E
V
A
AFA
A
G
A
E
A
QLS
G
E
L
A
V
--
C
AGS
C
GPG
N
LH
L
I
N
GL
F
D
C
HR
N
HV
P
VL
A
I
A
A
HIPSSE
IG
--
S
G
Y
FQE
T
H
PQ
--------
ELFRECS
H
YCE
LV
SSP
E
Q
I
P
QV
L
AI
A
MRK
A
V
L
-
N
R
-
G
V
S
I
V
V
LP
G
DV
ALKPA---
---
PEGATMHWYHAPQ
P
VVTPEEEE
L
RK
L
AQL
L
RY
S
SN
I
A
L
MC
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
IVHA
L
R
G
KE
HV
E
YD
N
P
YDV
GM
T
G
L
I
G
FSSGFHT
M
M
NAD
T
L
VL
L
G
T
Q
F
PY
R
A------
F
Y
P
T
D
A
KI
I
Q
IDI
N
P
A
S
I
GAHSKVD
M
A
L
VGD
IKST
L
RA
LL
PL
V
EEKADRK
F
L
D
--
--
-
-
K
ALEDY
R
DARKGLDDLAKPS
E
----------------------------
K
A
IHPQYLAQQ
I
SH
----
FAADDAIF
T
C
DVG
TP
T
V
W
AA
RY
-
LKMNG
K
R
RL
L
G
S
F
--------
NH
G
S
M
A
N
AM
P
Q
A
L
GA
QA
T
E
P
ERQ
VV
A
MC
GDG
GFS
M
LMG
D
FL
S
VV
Q
MK
LPV
K
IV
VF
NN
SV
LG
F
V
A
-
--ME
M
KAGGYLTDGTELHD
-----------
TN
F
AR
I
A
E
A
C
G
IT
G
IR
V
EKAS
E
VDE
AL
QRAFSI
---
DG
P
VL
V
D
V
V
VA
KE
--------
E
LAI
P
P
Q
IK
fig|344610.7.peg.808
Escherichia coli 53638 (9-539/572)
I
A
KT
L
ESA
GV
KR
I
W
G
VT
G
DS
L
NG
L
S
D
S
L
NRM
-
G
T
I
E
W
M
ST
RHE
E
V
A
AFA
A
G
A
E
A
QLS
G
E
L
A
V
--
C
AGS
C
GPG
N
LH
L
I
N
GL
F
D
C
HR
N
HV
P
VL
A
I
A
A
HIPSSE
IG
--
S
G
Y
FQE
T
H
PQ
--------
ELFRECS
H
YCE
LV
SSP
E
Q
I
P
QV
L
AI
A
MRK
A
V
L
-
N
R
-
G
V
S
I
V
V
LP
G
DV
ALKPA---
---
PEGATMHWYHAPQ
P
VVTPEEEE
L
RK
L
AQL
L
RY
S
SN
I
A
L
MC
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
IVHA
L
R
G
KE
HV
E
YD
N
P
YDV
GM
T
G
L
I
G
FSSGFHT
M
M
NAD
T
L
VL
L
G
T
Q
F
PY
R
A------
F
Y
P
T
D
A
KI
I
Q
IDI
N
P
A
S
I
GAHSKVD
M
A
L
VGD
IKST
L
RA
LL
PL
V
EEKADRK
F
L
D
--
--
-
-
K
ALEDY
R
DARKGLDDLAKPS
E
----------------------------
K
A
IHPQYLAQQ
I
SH
----
FAADDAIF
T
C
DVG
TP
T
V
W
AA
RY
-
LKMNG
K
R
RL
L
G
S
F
--------
NH
G
S
M
A
N
AM
P
Q
A
L
GA
QA
T
E
P
ERQ
VV
A
MC
GDG
GFS
M
LMG
D
FL
S
VV
Q
MK
LPV
K
IV
VF
NN
SV
LG
F
V
A
-
--ME
M
KAGGYLTDGTELHD
-----------
TN
F
AR
I
A
E
A
C
G
IT
G
IR
V
EKAS
E
VDE
AL
QRAFSI
---
DG
P
VL
V
D
V
V
VA
KE
--------
E
LAI
P
P
Q
IK
fig|413997.3.peg.917
Escherichia coli B str. REL606 (9-539/572)
I
A
KT
L
ESA
GV
KR
I
W
G
VT
G
DS
L
NG
L
S
D
S
L
NRM
-
G
T
I
E
W
M
ST
RHE
E
V
A
AFA
A
G
A
E
A
QLS
G
E
L
A
V
--
C
AGS
C
GPG
N
LH
L
I
N
GL
F
D
C
HR
N
HV
P
VL
A
I
A
A
HIPSSE
IG
--
S
G
Y
FQE
T
H
PQ
--------
ELFRECS
H
YCE
LV
SSP
E
Q
I
P
QV
L
AI
A
MRK
A
V
L
-
N
R
-
G
V
S
I
V
V
LP
G
DV
ALKPA---
---
PEGATMHWYHAPQ
P
VVTPEEEE
L
RK
L
AQL
L
RY
S
SN
I
A
L
MC
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
IVHA
L
R
G
KE
HV
E
YD
N
P
YDV
GM
T
G
L
I
G
FSSGFHT
M
M
NAD
T
L
VL
L
G
T
Q
F
PY
R
A------
F
Y
P
T
D
A
KI
I
Q
IDI
N
P
A
S
I
GAHSKVD
M
A
L
VGD
IKST
L
RA
LL
PL
V
EEKADRK
F
L
D
--
--
-
-
K
ALEDY
R
DARKGLDDLAKPS
E
----------------------------
K
A
IHPQYLAQQ
I
SH
----
FAADDAIF
T
C
DVG
TP
T
V
W
AA
RY
-
LKMNG
K
R
RL
L
G
S
F
--------
NH
G
S
M
A
N
AM
P
Q
A
L
GA
QA
T
E
P
ERQ
VV
A
MC
GDG
GFS
M
LMG
D
FL
S
VV
Q
MK
LPV
K
IV
VF
NN
SV
LG
F
V
A
-
--ME
M
KAGGYLTDGTELHD
-----------
TN
F
AR
I
A
E
A
C
G
IT
G
IR
V
EKAS
E
VDE
AL
QRAFSI
---
DG
P
VL
V
D
V
V
VA
KE
--------
E
LAI
P
P
Q
IK
fig|511693.5.peg.942
Escherichia coli BL21 (9-539/572)
I
A
KT
L
ESA
GV
KR
I
W
G
VT
G
DS
L
NG
L
S
D
S
L
NRM
-
G
T
I
E
W
M
ST
RHE
E
V
A
AFA
A
G
A
E
A
QLS
G
E
L
A
V
--
C
AGS
C
GPG
N
LH
L
I
N
GL
F
D
C
HR
N
HV
P
VL
A
I
A
A
HIPSSE
IG
--
S
G
Y
FQE
T
H
PQ
--------
ELFRECS
H
YCE
LV
SSP
E
Q
I
P
QV
L
AI
A
MRK
A
V
L
-
N
R
-
G
V
S
I
V
V
LP
G
DV
ALKPA---
---
PEGATMHWYHAPQ
P
VVTPEEEE
L
RK
L
AQL
L
RY
S
SN
I
A
L
MC
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
IVHA
L
R
G
KE
HV
E
YD
N
P
YDV
GM
T
G
L
I
G
FSSGFHT
M
M
NAD
T
L
VL
L
G
T
Q
F
PY
R
A------
F
Y
P
T
D
A
KI
I
Q
IDI
N
P
A
S
I
GAHSKVD
M
A
L
VGD
IKST
L
RA
LL
PL
V
EEKADRK
F
L
D
--
--
-
-
K
ALEDY
R
DARKGLDDLAKPS
E
----------------------------
K
A
IHPQYLAQQ
I
SH
----
FAADDAIF
T
C
DVG
TP
T
V
W
AA
RY
-
LKMNG
K
R
RL
L
G
S
F
--------
NH
G
S
M
A
N
AM
P
Q
A
L
GA
QA
T
E
P
ERQ
VV
A
MC
GDG
GFS
M
LMG
D
FL
S
VV
Q
MK
LPV
K
IV
VF
NN
SV
LG
F
V
A
-
--ME
M
KAGGYLTDGTELHD
-----------
TN
F
AR
I
A
E
A
C
G
IT
G
IR
V
EKAS
E
VDE
AL
QRAFSI
---
DG
P
VL
V
D
V
V
VA
KE
--------
E
LAI
P
P
Q
IK
fig|469008.4.peg.2821
Escherichia coli BL21(DE3) (9-539/572)
I
A
KT
L
ESA
GV
KR
I
W
G
VT
G
DS
L
NG
L
S
D
S
L
NRM
-
G
T
I
E
W
M
ST
RHE
E
V
A
AFA
A
G
A
E
A
QLS
G
E
L
A
V
--
C
AGS
C
GPG
N
LH
L
I
N
GL
F
D
C
HR
N
HV
P
VL
A
I
A
A
HIPSSE
IG
--
S
G
Y
FQE
T
H
PQ
--------
ELFRECS
H
YCE
LV
SSP
E
Q
I
P
QV
L
AI
A
MRK
A
V
L
-
N
R
-
G
V
S
I
V
V
LP
G
DV
ALKPA---
---
PEGATMHWYHAPQ
P
VVTPEEEE
L
RK
L
AQL
L
RY
S
SN
I
A
L
MC
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
IVHA
L
R
G
KE
HV
E
YD
N
P
YDV
GM
T
G
L
I
G
FSSGFHT
M
M
NAD
T
L
VL
L
G
T
Q
F
PY
R
A------
F
Y
P
T
D
A
KI
I
Q
IDI
N
P
A
S
I
GAHSKVD
M
A
L
VGD
IKST
L
RA
LL
PL
V
EEKADRK
F
L
D
--
--
-
-
K
ALEDY
R
DARKGLDDLAKPS
E
----------------------------
K
A
IHPQYLAQQ
I
SH
----
FAADDAIF
T
C
DVG
TP
T
V
W
AA
RY
-
LKMNG
K
R
RL
L
G
S
F
--------
NH
G
S
M
A
N
AM
P
Q
A
L
GA
QA
T
E
P
ERQ
VV
A
MC
GDG
GFS
M
LMG
D
FL
S
VV
Q
MK
LPV
K
IV
VF
NN
SV
LG
F
V
A
-
--ME
M
KAGGYLTDGTELHD
-----------
TN
F
AR
I
A
E
A
C
G
IT
G
IR
V
EKAS
E
VDE
AL
QRAFSI
---
DG
P
VL
V
D
V
V
VA
KE
--------
E
LAI
P
P
Q
IK
fig|749547.3.peg.1573
Escherichia coli MS 187-1 (9-539/572)
I
A
KT
L
ESA
GV
KR
I
W
G
VT
G
DS
L
NG
L
S
D
S
L
NRM
-
G
T
I
E
W
M
ST
RHE
E
V
A
AFA
A
G
A
E
A
QLS
G
E
L
A
V
--
C
AGS
C
GPG
N
LH
L
I
N
GL
F
D
C
HR
N
HV
P
VL
A
I
A
A
HIPSSE
IG
--
S
G
Y
FQE
T
H
PQ
--------
ELFRECS
H
YCE
LV
SSP
E
Q
I
P
QV
L
AI
A
MRK
A
V
L
-
N
R
-
G
V
S
I
V
V
LP
G
DV
ALKPA---
---
PEGATMHWYHAPQ
P
VVTPEEEE
L
RK
L
AQL
L
RY
S
SN
I
A
L
MC
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
IVHA
L
R
G
KE
HV
E
YD
N
P
YDV
GM
T
G
L
I
G
FSSGFHT
M
M
NAD
T
L
VL
L
G
T
Q
F
PY
R
A------
F
Y
P
T
D
A
KI
I
Q
IDI
N
P
A
S
I
GAHSKVD
M
A
L
VGD
IKST
L
RA
LL
PL
V
EEKADRK
F
L
D
--
--
-
-
K
ALEDY
R
DARKGLDDLAKPS
E
----------------------------
K
A
IHPQYLAQQ
I
SH
----
FAADDAIF
T
C
DVG
TP
T
V
W
AA
RY
-
LKMNG
K
R
RL
L
G
S
F
--------
NH
G
S
M
A
N
AM
P
Q
A
L
GA
QA
T
E
P
ERQ
VV
A
MC
GDG
GFS
M
LMG
D
FL
S
VV
Q
MK
LPV
K
IV
VF
NN
SV
LG
F
V
A
-
--ME
M
KAGGYLTDGTELHD
-----------
TN
F
AR
I
A
E
A
C
G
IT
G
IR
V
EKAS
E
VDE
AL
QRAFSI
---
DG
P
VL
V
D
V
V
VA
KE
--------
E
LAI
P
P
Q
IK
fig|344601.3.peg.2463
Escherichia coli B171 (9-539/572)
I
A
KT
L
ESA
GV
KR
I
W
G
VT
G
DS
L
NG
L
S
D
S
L
NRM
-
G
T
I
E
W
M
ST
RHE
E
V
A
AFA
A
G
A
E
A
QLS
G
E
L
A
V
--
C
AGS
C
GPG
N
LH
L
I
N
GL
F
D
C
HR
N
HV
P
VL
A
I
A
A
HIPSSE
IG
--
S
G
Y
FQE
T
H
PQ
--------
ELFRECS
H
YCE
LV
SSP
E
Q
I
P
QV
L
AI
A
MRK
A
V
L
-
N
R
-
G
V
S
V
V
V
LP
G
DV
ALKPA---
---
PEGATTHWYHAPQ
P
VVTPEEEE
L
RK
L
AQL
L
RY
S
SN
I
A
L
MC
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
IVHA
L
R
G
KE
HV
E
YD
N
P
YDV
GM
T
G
L
I
G
FSSGFHT
M
M
NAD
T
L
VL
L
G
T
Q
F
PY
R
A------
F
Y
P
T
D
A
KI
I
Q
IDI
N
P
A
S
I
GAHSKVD
M
A
L
VGD
IKST
L
RA
LL
PL
V
EEKADRK
F
L
D
--
--
-
-
K
ALEDY
R
DARKGLDDLAKPS
E
----------------------------
K
A
IHPQYLAQQ
I
SH
----
FAADDAIF
T
C
DVG
TP
T
V
W
AA
RY
-
LKMNG
K
R
RL
L
G
S
F
--------
NH
G
S
M
A
N
AM
P
Q
A
L
GA
QA
T
E
P
ERQ
VV
A
MC
GDG
GFS
M
LMG
D
FL
S
VV
Q
MK
LPV
K
IV
VF
NN
SV
LG
F
V
A
-
--ME
M
KAGGYLTDGTELHD
-----------
TN
F
AR
I
A
E
A
W
G
IT
G
IR
V
EKAS
E
VDE
AL
QRAFSI
---
DG
P
VL
V
D
V
V
VA
KE
--------
E
LAI
P
P
Q
IK
fig|344601.5.peg.2566
Escherichia coli B171 (9-539/572)
I
A
KT
L
ESA
GV
KR
I
W
G
VT
G
DS
L
NG
L
S
D
S
L
NRM
-
G
T
I
E
W
M
ST
RHE
E
V
A
AFA
A
G
A
E
A
QLS
G
E
L
A
V
--
C
AGS
C
GPG
N
LH
L
I
N
GL
F
D
C
HR
N
HV
P
VL
A
I
A
A
HIPSSE
IG
--
S
G
Y
FQE
T
H
PQ
--------
ELFRECS
H
YCE
LV
SSP
E
Q
I
P
QV
L
AI
A
MRK
A
V
L
-
N
R
-
G
V
S
V
V
V
LP
G
DV
ALKPA---
---
PEGATTHWYHAPQ
P
VVTPEEEE
L
RK
L
AQL
L
RY
S
SN
I
A
L
MC
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
IVHA
L
R
G
KE
HV
E
YD
N
P
YDV
GM
T
G
L
I
G
FSSGFHT
M
M
NAD
T
L
VL
L
G
T
Q
F
PY
R
A------
F
Y
P
T
D
A
KI
I
Q
IDI
N
P
A
S
I
GAHSKVD
M
A
L
VGD
IKST
L
RA
LL
PL
V
EEKADRK
F
L
D
--
--
-
-
K
ALEDY
R
DARKGLDDLAKPS
E
----------------------------
K
A
IHPQYLAQQ
I
SH
----
FAADDAIF
T
C
DVG
TP
T
V
W
AA
RY
-
LKMNG
K
R
RL
L
G
S
F
--------
NH
G
S
M
A
N
AM
P
Q
A
L
GA
QA
T
E
P
ERQ
VV
A
MC
GDG
GFS
M
LMG
D
FL
S
VV
Q
MK
LPV
K
IV
VF
NN
SV
LG
F
V
A
-
--ME
M
KAGGYLTDGTELHD
-----------
TN
F
AR
I
A
E
A
W
G
IT
G
IR
V
EKAS
E
VDE
AL
QRAFSI
---
DG
P
VL
V
D
V
V
VA
KE
--------
E
LAI
P
P
Q
IK
fig|656417.3.peg.1109
Escherichia coli M605 (9-539/572)
I
A
KT
L
ESA
GV
KR
I
W
G
VT
G
DS
L
NG
L
S
D
S
L
NRM
-
G
T
I
E
W
M
ST
RHE
E
V
A
AFA
A
G
A
E
A
QLS
G
E
L
A
V
--
C
AGS
C
GPG
N
LH
L
I
N
GL
F
D
C
HR
N
HV
P
VL
A
I
A
A
HIPSSE
IG
--
S
G
Y
FQE
T
H
PQ
--------
ELFRECS
H
YCE
LV
SSP
E
Q
I
P
QV
L
AI
A
MRK
A
V
L
-
N
R
-
G
V
S
V
V
V
LP
G
DV
ALKPA---
---
PEGATTHWYHAPQ
P
VVTPEEEE
L
RK
L
AQL
L
RY
S
SN
I
A
L
MC
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
IVHA
L
R
G
KE
HV
E
YD
N
P
YDV
GM
T
G
L
I
G
FSSGFHT
M
M
NAD
T
L
VL
L
G
T
Q
F
PY
R
A------
F
Y
P
T
D
A
KI
I
Q
IDI
N
P
A
S
I
GAHSKVD
M
A
L
VGD
IKST
L
RA
LL
PL
V
EEKTERK
F
L
D
--
--
-
-
K
AREDY
R
DARKGLDDLAKPS
E
----------------------------
K
A
IHPQYLAQQ
I
SH
----
FAADDAIF
T
C
DVG
TP
T
V
W
AA
RY
-
LKMNG
K
R
RL
L
G
S
F
--------
NH
G
S
M
A
N
AM
P
Q
A
L
GA
QA
T
E
P
ERQ
VV
A
MC
GDG
GFS
M
LMG
D
FL
S
VV
Q
MK
LPV
K
I
I
VF
NN
SV
LG
F
V
A
-
--ME
M
KAGGYLTDGTELHD
-----------
TN
F
AR
I
A
E
A
C
G
IT
G
IR
V
EKAS
E
IDE
AL
QRAFSI
---
DG
P
VL
V
D
V
V
VA
KE
--------
E
LAI
P
P
Q
IK
fig|585397.7.peg.846
Escherichia coli ED1a (9-539/572)
I
A
KT
L
ESA
GV
KR
I
W
G
VT
G
DS
L
NG
L
S
D
S
L
NRM
-
G
T
I
E
W
V
ST
RHE
E
V
A
AFA
A
G
A
E
A
QLS
G
E
L
A
V
--
C
AGS
C
GPG
N
LH
L
I
N
GL
F
D
C
HR
N
HV
P
VL
A
I
A
A
HIPSSE
IG
--
S
G
Y
FQE
T
H
PQ
--------
ELFRECS
H
YCE
LV
SSP
E
Q
I
P
QV
L
AI
A
MRK
A
V
L
-
N
R
-
G
V
S
V
V
V
LP
G
DV
ALKPA---
---
PEGATTHWYHAPQ
P
VVTPEEEE
L
RK
L
AQL
L
RY
S
SN
I
A
L
MC
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
IVHA
L
R
G
KE
HV
E
YD
N
P
YDV
GM
T
G
L
I
G
FSSGFHT
M
M
NAD
T
L
VL
L
G
T
Q
F
PY
R
A------
F
Y
P
T
D
A
KI
I
Q
IDI
N
P
A
S
I
GAHSKVD
M
A
L
VGD
IKST
L
RA
LL
PL
V
EEKTDRK
F
L
D
--
--
-
-
K
ALEDY
R
DARKGLDDLAKPS
E
----------------------------
K
A
IHPQYLAQQ
I
SH
----
FAADDAIF
T
C
DVG
TP
T
V
W
AA
RY
-
LKMNG
K
R
RL
L
G
S
F
--------
NH
G
S
M
A
N
AM
P
Q
A
L
GA
QA
T
E
P
ERQ
VV
A
MC
GDG
GFS
M
LMG
D
FL
S
VV
Q
MK
LPV
K
I
I
VF
NN
SV
LG
F
V
A
-
--ME
M
KAGGYLTDGTELHD
-----------
TN
F
AR
I
A
E
A
C
G
IT
G
IR
V
EKAS
E
IDE
AL
QRAFSI
---
DG
P
VL
V
D
V
V
VA
KE
--------
E
LAI
P
P
Q
IK
fig|585397.9.peg.846
Escherichia coli ED1a (9-539/572)
I
A
KT
L
ESA
GV
KR
I
W
G
VT
G
DS
L
NG
L
S
D
S
L
NRM
-
G
T
I
E
W
V
ST
RHE
E
V
A
AFA
A
G
A
E
A
QLS
G
E
L
A
V
--
C
AGS
C
GPG
N
LH
L
I
N
GL
F
D
C
HR
N
HV
P
VL
A
I
A
A
HIPSSE
IG
--
S
G
Y
FQE
T
H
PQ
--------
ELFRECS
H
YCE
LV
SSP
E
Q
I
P
QV
L
AI
A
MRK
A
V
L
-
N
R
-
G
V
S
V
V
V
LP
G
DV
ALKPA---
---
PEGATTHWYHAPQ
P
VVTPEEEE
L
RK
L
AQL
L
RY
S
SN
I
A
L
MC
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
IVHA
L
R
G
KE
HV
E
YD
N
P
YDV
GM
T
G
L
I
G
FSSGFHT
M
M
NAD
T
L
VL
L
G
T
Q
F
PY
R
A------
F
Y
P
T
D
A
KI
I
Q
IDI
N
P
A
S
I
GAHSKVD
M
A
L
VGD
IKST
L
RA
LL
PL
V
EEKTDRK
F
L
D
--
--
-
-
K
ALEDY
R
DARKGLDDLAKPS
E
----------------------------
K
A
IHPQYLAQQ
I
SH
----
FAADDAIF
T
C
DVG
TP
T
V
W
AA
RY
-
LKMNG
K
R
RL
L
G
S
F
--------
NH
G
S
M
A
N
AM
P
Q
A
L
GA
QA
T
E
P
ERQ
VV
A
MC
GDG
GFS
M
LMG
D
FL
S
VV
Q
MK
LPV
K
I
I
VF
NN
SV
LG
F
V
A
-
--ME
M
KAGGYLTDGTELHD
-----------
TN
F
AR
I
A
E
A
C
G
IT
G
IR
V
EKAS
E
IDE
AL
QRAFSI
---
DG
P
VL
V
D
V
V
VA
KE
--------
E
LAI
P
P
Q
IK
fig|656440.3.peg.780
Escherichia coli TA206 (9-539/572)
I
A
KT
L
ESA
GV
KR
I
W
G
VT
G
DS
L
NG
L
S
D
S
L
NRM
-
G
T
I
E
W
V
ST
RHE
E
V
A
AFA
A
G
A
E
A
QLS
G
E
L
A
V
--
C
AGS
C
GPG
N
LH
L
I
N
GL
F
D
C
HR
N
HV
P
VL
A
I
A
A
HIPSSE
IG
--
S
G
Y
FQE
T
H
PQ
--------
ELFRECS
H
YCE
LV
SSP
E
Q
I
P
QV
L
AI
A
MRK
A
V
L
-
N
R
-
G
V
S
V
V
V
LP
G
DV
ALKPA---
---
PEGATTHWYHAPQ
P
VVTPEEEE
L
RK
L
AQL
L
RY
S
SN
I
A
L
MC
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
IVHA
L
R
G
KE
HV
E
YD
N
P
YDV
GM
T
G
L
I
G
FSSGFHT
M
M
NAD
T
L
VL
L
G
T
Q
F
PY
R
A------
F
Y
P
T
D
A
KI
I
Q
IDI
N
P
A
S
I
GAHSKVD
M
A
L
VGD
IKST
L
RA
LL
PL
V
EEKTDRK
F
L
D
--
--
-
-
K
ALEDY
R
DARKGLDDLAKPS
E
----------------------------
K
A
IHPQYLAQQ
I
SH
----
FAADDAIF
T
C
DVG
TP
T
V
W
AA
RY
-
LKMNG
K
R
RL
L
G
S
F
--------
NH
G
S
M
A
N
AM
P
Q
A
L
GA
QA
T
E
P
ERQ
VV
A
MC
GDG
GFS
M
LMG
D
FL
S
VV
Q
MK
LPV
K
I
I
VF
NN
SV
LG
F
V
A
-
--ME
M
KAGGYLTDGTELHD
-----------
TN
F
AR
I
A
E
A
C
G
IT
G
IR
V
EKAS
E
IDE
AL
QRAFSI
---
DG
P
VL
V
D
V
V
VA
KE
--------
E
LAI
P
P
Q
IK
fig|525281.3.peg.2081
Escherichia coli 83972 (9-539/572)
I
A
KT
L
ESA
GV
KR
I
W
G
VT
G
DS
L
NG
L
S
D
S
L
NRM
-
G
T
I
E
W
M
ST
RHE
E
V
A
AFA
A
G
A
E
A
QLS
G
E
L
A
V
--
C
AGS
C
GPG
N
LH
L
I
N
GL
F
D
C
HR
N
HV
P
VL
A
I
A
A
HIPSSE
IG
--
S
G
Y
FQE
T
H
PQ
--------
ELFRECS
H
YCE
LV
SSP
E
Q
I
P
QV
L
AI
A
MRK
A
V
L
-
N
R
-
G
V
S
V
V
V
LP
G
DV
ALKPA---
---
PEGATTHWYHAPQ
P
VVTPEEEE
L
RK
L
AQL
L
RY
S
SN
I
A
L
MC
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
IVHA
L
R
G
KE
HV
E
YD
N
P
YDV
GM
T
G
L
I
G
FSSGFHT
M
M
NAD
T
L
VL
L
G
T
Q
F
PY
R
A------
F
Y
P
T
D
A
KI
I
Q
IDI
N
P
A
S
I
GAHSKVD
M
A
L
VGD
IKST
L
RA
LL
PL
V
EEKTDRK
F
L
D
--
--
-
-
K
ALEDY
R
DARKGLDDLAKPS
E
----------------------------
K
A
IHPQYLAQQ
I
SH
----
FAADDAIF
T
C
DVG
TP
T
V
W
AA
RY
-
LKMNG
K
R
RL
L
G
S
F
--------
NH
G
S
M
A
N
AM
P
Q
A
L
GA
QA
T
E
P
ERQ
VV
A
MC
GDG
GFS
M
LMG
D
FL
S
VM
Q
MK
LPV
K
I
I
VF
NN
SV
LG
F
V
A
-
--ME
M
KAGGYLTDGTELHD
-----------
TN
F
AR
I
A
E
A
C
G
IT
G
IR
V
EKAS
E
IDE
AL
QRAFSI
---
DG
P
VL
V
D
V
V
VA
KE
--------
E
LAI
P
P
Q
IK
fig|655817.3.peg.960
Escherichia coli ABU 83972 (9-539/572)
I
A
KT
L
ESA
GV
KR
I
W
G
VT
G
DS
L
NG
L
S
D
S
L
NRM
-
G
T
I
E
W
M
ST
RHE
E
V
A
AFA
A
G
A
E
A
QLS
G
E
L
A
V
--
C
AGS
C
GPG
N
LH
L
I
N
GL
F
D
C
HR
N
HV
P
VL
A
I
A
A
HIPSSE
IG
--
S
G
Y
FQE
T
H
PQ
--------
ELFRECS
H
YCE
LV
SSP
E
Q
I
P
QV
L
AI
A
MRK
A
V
L
-
N
R
-
G
V
S
V
V
V
LP
G
DV
ALKPA---
---
PEGATTHWYHAPQ
P
VVTPEEEE
L
RK
L
AQL
L
RY
S
SN
I
A
L
MC
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
IVHA
L
R
G
KE
HV
E
YD
N
P
YDV
GM
T
G
L
I
G
FSSGFHT
M
M
NAD
T
L
VL
L
G
T
Q
F
PY
R
A------
F
Y
P
T
D
A
KI
I
Q
IDI
N
P
A
S
I
GAHSKVD
M
A
L
VGD
IKST
L
RA
LL
PL
V
EEKTDRK
F
L
D
--
--
-
-
K
ALEDY
R
DARKGLDDLAKPS
E
----------------------------
K
A
IHPQYLAQQ
I
SH
----
FAADDAIF
T
C
DVG
TP
T
V
W
AA
RY
-
LKMNG
K
R
RL
L
G
S
F
--------
NH
G
S
M
A
N
AM
P
Q
A
L
GA
QA
T
E
P
ERQ
VV
A
MC
GDG
GFS
M
LMG
D
FL
S
VM
Q
MK
LPV
K
I
I
VF
NN
SV
LG
F
V
A
-
--ME
M
KAGGYLTDGTELHD
-----------
TN
F
AR
I
A
E
A
C
G
IT
G
IR
V
EKAS
E
IDE
AL
QRAFSI
---
DG
P
VL
V
D
V
V
VA
KE
--------
E
LAI
P
P
Q
IK
fig|199310.1.peg.977
Escherichia coli CFT073 (9-539/572)
I
A
KT
L
ESA
GV
KR
I
W
G
VT
G
DS
L
NG
L
S
D
S
L
NRM
-
G
T
I
E
W
M
ST
RHE
E
V
A
AFA
A
G
A
E
A
QLS
G
E
L
A
V
--
C
AGS
C
GPG
N
LH
L
I
N
GL
F
D
C
HR
N
HV
P
VL
A
I
A
A
HIPSSE
IG
--
S
G
Y
FQE
T
H
PQ
--------
ELFRECS
H
YCE
LV
SSP
E
Q
I
P
QV
L
AI
A
MRK
A
V
L
-
N
R
-
G
V
S
V
V
V
LP
G
DV
ALKPA---
---
PEGATTHWYHAPQ
P
VVTPEEEE
L
RK
L
AQL
L
RY
S
SN
I
A
L
MC
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
IVHA
L
R
G
KE
HV
E
YD
N
P
YDV
GM
T
G
L
I
G
FSSGFHT
M
M
NAD
T
L
VL
L
G
T
Q
F
PY
R
A------
F
Y
P
T
D
A
KI
I
Q
IDI
N
P
A
S
I
GAHSKVD
M
A
L
VGD
IKST
L
RA
LL
PL
V
EEKTDRK
F
L
D
--
--
-
-
K
ALEDY
R
DARKGLDDLAKPS
E
----------------------------
K
A
IHPQYLAQQ
I
SH
----
FAADDAIF
T
C
DVG
TP
T
V
W
AA
RY
-
LKMNG
K
R
RL
L
G
S
F
--------
NH
G
S
M
A
N
AM
P
Q
A
L
GA
QA
T
E
P
ERQ
VV
A
MC
GDG
GFS
M
LMG
D
FL
S
VM
Q
MK
LPV
K
I
I
VF
NN
SV
LG
F
V
A
-
--ME
M
KAGGYLTDGTELHD
-----------
TN
F
AR
I
A
E
A
C
G
IT
G
IR
V
EKAS
E
IDE
AL
QRAFSI
---
DG
P
VL
V
D
V
V
VA
KE
--------
E
LAI
P
P
Q
IK
fig|199310.4.peg.957
Escherichia coli CFT073 (9-539/572)
I
A
KT
L
ESA
GV
KR
I
W
G
VT
G
DS
L
NG
L
S
D
S
L
NRM
-
G
T
I
E
W
M
ST
RHE
E
V
A
AFA
A
G
A
E
A
QLS
G
E
L
A
V
--
C
AGS
C
GPG
N
LH
L
I
N
GL
F
D
C
HR
N
HV
P
VL
A
I
A
A
HIPSSE
IG
--
S
G
Y
FQE
T
H
PQ
--------
ELFRECS
H
YCE
LV
SSP
E
Q
I
P
QV
L
AI
A
MRK
A
V
L
-
N
R
-
G
V
S
V
V
V
LP
G
DV
ALKPA---
---
PEGATTHWYHAPQ
P
VVTPEEEE
L
RK
L
AQL
L
RY
S
SN
I
A
L
MC
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
IVHA
L
R
G
KE
HV
E
YD
N
P
YDV
GM
T
G
L
I
G
FSSGFHT
M
M
NAD
T
L
VL
L
G
T
Q
F
PY
R
A------
F
Y
P
T
D
A
KI
I
Q
IDI
N
P
A
S
I
GAHSKVD
M
A
L
VGD
IKST
L
RA
LL
PL
V
EEKTDRK
F
L
D
--
--
-
-
K
ALEDY
R
DARKGLDDLAKPS
E
----------------------------
K
A
IHPQYLAQQ
I
SH
----
FAADDAIF
T
C
DVG
TP
T
V
W
AA
RY
-
LKMNG
K
R
RL
L
G
S
F
--------
NH
G
S
M
A
N
AM
P
Q
A
L
GA
QA
T
E
P
ERQ
VV
A
MC
GDG
GFS
M
LMG
D
FL
S
VM
Q
MK
LPV
K
I
I
VF
NN
SV
LG
F
V
A
-
--ME
M
KAGGYLTDGTELHD
-----------
TN
F
AR
I
A
E
A
C
G
IT
G
IR
V
EKAS
E
IDE
AL
QRAFSI
---
DG
P
VL
V
D
V
V
VA
KE
--------
E
LAI
P
P
Q
IK
fig|749546.3.peg.4887
Escherichia coli MS 185-1 (9-539/572)
I
A
KT
L
ESA
GV
KR
I
W
G
VT
G
DS
L
NG
L
S
D
S
L
NRM
-
G
T
I
E
W
M
ST
RHE
E
V
A
AFA
A
G
A
E
A
QLS
G
E
L
A
V
--
C
AGS
C
GPG
N
LH
L
I
N
GL
F
D
C
HR
N
HV
P
VL
A
I
A
A
HIPSSE
IG
--
S
G
Y
FQE
T
H
PQ
--------
ELFRECS
H
YCE
LV
SSP
E
Q
I
P
QV
L
AI
A
MRK
A
V
L
-
N
R
-
G
V
S
V
V
V
LP
G
DV
ALKPA---
---
PEGATTHWYHAPQ
P
VVTPEEEE
L
RK
L
AQL
L
RY
S
SN
I
A
L
MC
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
IVHA
L
R
G
KE
HV
E
YD
N
P
YDV
GM
T
G
L
I
G
FSSGFHT
M
M
NAD
T
L
VL
L
G
T
Q
F
PY
R
A------
F
Y
P
T
D
A
KI
I
Q
IDI
N
P
A
S
I
GAHSKVD
M
A
L
VGD
IKST
L
RA
LL
PL
V
EEKTDRK
F
L
D
--
--
-
-
K
ALEDY
R
DARKGLDDLAKPS
E
----------------------------
K
A
IHPQYLAQQ
I
SH
----
FAADDAIF
T
C
DVG
TP
T
V
W
AA
RY
-
LKMNG
K
R
RL
L
G
S
F
--------
NH
G
S
M
A
N
AM
P
Q
A
L
GA
QA
T
E
P
ERQ
VV
A
MC
GDG
GFS
M
LMG
D
FL
S
VM
Q
MK
LPV
K
I
I
VF
NN
SV
LG
F
V
A
-
--ME
M
KAGGYLTDGTELHD
-----------
TN
F
AR
I
A
E
A
C
G
IT
G
IR
V
EKAS
E
IDE
AL
QRAFSI
---
DG
P
VL
V
D
V
V
VA
KE
--------
E
LAI
P
P
Q
IK
fig|749528.3.peg.4613
Escherichia coli MS 45-1 (9-539/572)
I
A
KT
L
ESA
GV
KR
I
W
G
VT
G
DS
L
NG
L
S
D
S
L
NRM
-
G
T
I
E
W
M
ST
RHE
E
V
A
AFA
A
G
A
E
A
QLS
G
E
L
A
V
--
C
AGS
C
GPG
N
LH
L
I
N
GL
F
D
C
HR
N
HV
P
VL
A
I
A
A
HIPSSE
IG
--
S
G
Y
FQE
T
H
PQ
--------
ELFRECS
H
YCE
LV
SSP
E
Q
I
P
QV
L
AI
A
MRK
A
V
L
-
N
R
-
G
V
S
V
V
V
LP
G
DV
ALKPA---
---
PEGATTHWYHAPQ
P
VVTPEEEE
L
RK
L
AQL
L
RY
S
SN
I
A
L
MC
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
IVHA
L
R
G
KE
HV
E
YD
N
P
YDV
GM
T
G
L
I
G
FSSGFHT
M
M
NAD
T
L
VL
L
G
T
Q
F
PY
R
A------
F
Y
P
T
D
A
KI
I
Q
IDI
N
P
A
S
I
GAHSKVD
M
A
L
VGD
IKST
L
RA
LL
PL
V
EEKTDRK
F
L
D
--
--
-
-
K
ALEDY
R
DARKGLDDLAKPS
E
----------------------------
K
A
IHPQYLAQQ
I
SH
----
FAADDAIF
T
C
DVG
TP
T
V
W
AA
RY
-
LKMNG
K
R
RL
L
G
S
F
--------
NH
G
S
M
A
N
AM
P
Q
A
L
GA
QA
T
E
P
ERQ
VV
A
MC
GDG
GFS
M
LMG
D
FL
S
VM
Q
MK
LPV
K
I
I
VF
NN
SV
LG
F
V
A
-
--ME
M
KAGGYLTDGTELHD
-----------
TN
F
AR
I
A
E
A
C
G
IT
G
IR
V
EKAS
E
IDE
AL
QRAFSI
---
DG
P
VL
V
D
V
V
VA
KE
--------
E
LAI
P
P
Q
IK
fig|362663.8.peg.894
Escherichia coli 536 (9-539/572)
I
A
KT
L
ESA
GV
KR
I
W
G
VT
G
DS
L
NG
L
S
D
S
L
NRM
-
G
T
I
E
W
M
ST
RHE
E
V
A
AFA
A
G
A
E
A
QLS
G
E
L
A
V
--
C
AGS
C
GPG
N
LH
L
I
N
GL
F
D
C
HR
N
HV
P
VL
A
I
A
A
HIPSSE
IG
--
S
G
Y
FQE
T
H
PQ
--------
ELFRECS
H
YCE
LV
SSP
E
Q
I
P
QV
L
AI
A
MRK
A
V
L
-
N
R
-
G
V
S
V
V
V
LP
G
DV
ALKPA---
---
PEGATTHWYHAPQ
P
VVTPEEEE
L
RK
L
AQL
L
RY
S
SN
I
A
L
MC
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
IVHA
L
R
G
KE
HV
E
YD
N
P
YDV
GM
T
G
L
I
G
FSSGFHT
M
M
NAD
T
L
VL
L
G
T
Q
F
PY
R
A------
F
Y
P
T
D
A
KI
I
Q
IDI
N
P
A
S
I
GAHSKVD
M
A
L
VGD
IKST
L
RA
LL
PL
V
EEKTERK
F
L
D
--
--
-
-
K
ALEDY
R
DARKGLDDLAKPS
E
----------------------------
K
A
IHPQYLAQQ
I
SH
----
FAADDAIF
T
C
DVG
TP
T
V
W
AA
RY
-
LKMNG
K
R
RL
L
G
S
F
--------
NH
G
S
M
A
N
AM
P
Q
A
L
GA
QA
T
E
P
ERQ
VV
A
MC
GDG
GFS
M
LMG
D
FL
S
VV
Q
MK
LPV
K
I
I
VF
NN
SV
LG
F
V
A
-
--ME
M
KAGGYLTDGTELHD
-----------
TN
F
AR
I
A
E
A
C
G
IT
G
IR
V
EKAS
E
IDE
AL
QRAFSI
---
DG
P
VL
V
D
V
V
VA
KE
--------
E
LAI
P
P
Q
IK
fig|362663.9.peg.894
Escherichia coli 536 (9-539/572)
I
A
KT
L
ESA
GV
KR
I
W
G
VT
G
DS
L
NG
L
S
D
S
L
NRM
-
G
T
I
E
W
M
ST
RHE
E
V
A
AFA
A
G
A
E
A
QLS
G
E
L
A
V
--
C
AGS
C
GPG
N
LH
L
I
N
GL
F
D
C
HR
N
HV
P
VL
A
I
A
A
HIPSSE
IG
--
S
G
Y
FQE
T
H
PQ
--------
ELFRECS
H
YCE
LV
SSP
E
Q
I
P
QV
L
AI
A
MRK
A
V
L
-
N
R
-
G
V
S
V
V
V
LP
G
DV
ALKPA---
---
PEGATTHWYHAPQ
P
VVTPEEEE
L
RK
L
AQL
L
RY
S
SN
I
A
L
MC
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
IVHA
L
R
G
KE
HV
E
YD
N
P
YDV
GM
T
G
L
I
G
FSSGFHT
M
M
NAD
T
L
VL
L
G
T
Q
F
PY
R
A------
F
Y
P
T
D
A
KI
I
Q
IDI
N
P
A
S
I
GAHSKVD
M
A
L
VGD
IKST
L
RA
LL
PL
V
EEKTERK
F
L
D
--
--
-
-
K
ALEDY
R
DARKGLDDLAKPS
E
----------------------------
K
A
IHPQYLAQQ
I
SH
----
FAADDAIF
T
C
DVG
TP
T
V
W
AA
RY
-
LKMNG
K
R
RL
L
G
S
F
--------
NH
G
S
M
A
N
AM
P
Q
A
L
GA
QA
T
E
P
ERQ
VV
A
MC
GDG
GFS
M
LMG
D
FL
S
VV
Q
MK
LPV
K
I
I
VF
NN
SV
LG
F
V
A
-
--ME
M
KAGGYLTDGTELHD
-----------
TN
F
AR
I
A
E
A
C
G
IT
G
IR
V
EKAS
E
IDE
AL
QRAFSI
---
DG
P
VL
V
D
V
V
VA
KE
--------
E
LAI
P
P
Q
IK
fig|340197.3.peg.2162
Escherichia coli F11 (9-539/572)
I
A
KT
L
ESA
GV
KR
I
W
G
VT
G
DS
L
NG
L
S
D
S
L
NRM
-
G
T
I
E
W
M
ST
RHE
E
V
A
AFA
A
G
A
E
A
QLS
G
E
L
A
V
--
C
AGS
C
GPG
N
LH
L
I
N
GL
F
D
C
HR
N
HV
P
VL
A
I
A
A
HIPSSE
IG
--
S
G
Y
FQE
T
H
PQ
--------
ELFRECS
H
YCE
LV
SSP
E
Q
I
P
QV
L
AI
A
MRK
A
V
L
-
N
R
-
G
V
S
V
V
V
LP
G
DV
ALKPA---
---
PEGATTHWYHAPQ
P
VVTPEEEE
L
RK
L
AQL
L
RY
S
SN
I
A
L
MC
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
IVHA
L
R
G
KE
HV
E
YD
N
P
YDV
GM
T
G
L
I
G
FSSGFHT
M
M
NAD
T
L
VL
L
G
T
Q
F
PY
R
A------
F
Y
P
T
D
A
KI
I
Q
IDI
N
P
A
S
I
GAHSKVD
M
A
L
VGD
IKST
L
RA
LL
PL
V
EEKTERK
F
L
D
--
--
-
-
K
ALEDY
R
DARKGLDDLAKPS
E
----------------------------
K
A
IHPQYLAQQ
I
SH
----
FAADDAIF
T
C
DVG
TP
T
V
W
AA
RY
-
LKMNG
K
R
RL
L
G
S
F
--------
NH
G
S
M
A
N
AM
P
Q
A
L
GA
QA
T
E
P
ERQ
VV
A
MC
GDG
GFS
M
LMG
D
FL
S
VV
Q
MK
LPV
K
I
I
VF
NN
SV
LG
F
V
A
-
--ME
M
KAGGYLTDGTELHD
-----------
TN
F
AR
I
A
E
A
C
G
IT
G
IR
V
EKAS
E
IDE
AL
QRAFSI
---
DG
P
VL
V
D
V
V
VA
KE
--------
E
LAI
P
P
Q
IK
fig|340197.5.peg.2276
Escherichia coli F11 (9-539/572)
I
A
KT
L
ESA
GV
KR
I
W
G
VT
G
DS
L
NG
L
S
D
S
L
NRM
-
G
T
I
E
W
M
ST
RHE
E
V
A
AFA
A
G
A
E
A
QLS
G
E
L
A
V
--
C
AGS
C
GPG
N
LH
L
I
N
GL
F
D
C
HR
N
HV
P
VL
A
I
A
A
HIPSSE
IG
--
S
G
Y
FQE
T
H
PQ
--------
ELFRECS
H
YCE
LV
SSP
E
Q
I
P
QV
L
AI
A
MRK
A
V
L
-
N
R
-
G
V
S
V
V
V
LP
G
DV
ALKPA---
---
PEGATTHWYHAPQ
P
VVTPEEEE
L
RK
L
AQL
L
RY
S
SN
I
A
L
MC
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
IVHA
L
R
G
KE
HV
E
YD
N
P
YDV
GM
T
G
L
I
G
FSSGFHT
M
M
NAD
T
L
VL
L
G
T
Q
F
PY
R
A------
F
Y
P
T
D
A
KI
I
Q
IDI
N
P
A
S
I
GAHSKVD
M
A
L
VGD
IKST
L
RA
LL
PL
V
EEKTERK
F
L
D
--
--
-
-
K
ALEDY
R
DARKGLDDLAKPS
E
----------------------------
K
A
IHPQYLAQQ
I
SH
----
FAADDAIF
T
C
DVG
TP
T
V
W
AA
RY
-
LKMNG
K
R
RL
L
G
S
F
--------
NH
G
S
M
A
N
AM
P
Q
A
L
GA
QA
T
E
P
ERQ
VV
A
MC
GDG
GFS
M
LMG
D
FL
S
VV
Q
MK
LPV
K
I
I
VF
NN
SV
LG
F
V
A
-
--ME
M
KAGGYLTDGTELHD
-----------
TN
F
AR
I
A
E
A
C
G
IT
G
IR
V
EKAS
E
IDE
AL
QRAFSI
---
DG
P
VL
V
D
V
V
VA
KE
--------
E
LAI
P
P
Q
IK
fig|749550.3.peg.3695
Escherichia coli MS 200-1 (9-539/572)
I
A
KT
L
ESA
GV
KR
I
W
G
VT
G
DS
L
NG
L
S
D
S
L
NRM
-
G
T
I
E
W
M
ST
RHE
E
V
A
AFA
A
G
A
E
A
QLS
G
E
L
A
V
--
C
AGS
C
GPG
N
LH
L
I
N
GL
F
D
C
HR
N
HV
P
VL
A
I
A
A
HIPSSE
IG
--
S
G
Y
FQE
T
H
PQ
--------
ELFRECS
H
YCE
LV
SSP
E
Q
I
P
QV
L
AI
A
MRK
A
V
L
-
N
R
-
G
V
S
V
V
V
LP
G
DV
ALKPA---
---
PEGATTHWYHAPQ
P
VVTPEEEE
L
RK
L
AQL
L
RY
S
SN
I
A
L
MC
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
IVHA
L
R
G
KE
HV
E
YD
N
P
YDV
GM
T
G
L
I
G
FSSGFHT
M
M
NAD
T
L
VL
L
G
T
Q
F
PY
R
A------
F
Y
P
T
D
A
KI
I
Q
IDI
N
P
A
S
I
GAHSKVD
M
A
L
VGD
IKST
L
RA
LL
PL
V
EEKTERK
F
L
D
--
--
-
-
K
ALEDY
R
DARKGLDDLAKPS
E
----------------------------
K
A
IHPQYLAQQ
I
SH
----
FAADDAIF
T
C
DVG
TP
T
V
W
AA
RY
-
LKMNG
K
R
RL
L
G
S
F
--------
NH
G
S
M
A
N
AM
P
Q
A
L
GA
QA
T
E
P
ERQ
VV
A
MC
GDG
GFS
M
LMG
D
FL
S
VV
Q
MK
LPV
K
I
I
VF
NN
SV
LG
F
V
A
-
--ME
M
KAGGYLTDGTELHD
-----------
TN
F
AR
I
A
E
A
C
G
IT
G
IR
V
EKAS
E
IDE
AL
QRAFSI
---
DG
P
VL
V
D
V
V
VA
KE
--------
E
LAI
P
P
Q
IK
fig|585057.4.peg.902
Escherichia coli IAI39 (9-539/572)
I
A
KT
L
ESA
GV
KR
I
W
G
VT
G
DS
L
NG
L
S
D
S
L
NRM
-
G
T
I
E
W
M
ST
RHE
E
V
A
AFA
A
G
A
E
A
QLS
G
E
L
A
V
--
C
AGS
C
GPG
N
LH
L
I
N
GL
F
D
C
HR
N
HV
P
VL
A
I
A
A
HIPSSE
IG
--
S
G
Y
FQE
T
H
PQ
--------
ELFRECS
H
YCE
LV
SSP
E
Q
I
P
QV
L
AI
A
MRK
A
V
L
-
N
R
-
G
V
S
V
V
V
LP
G
DV
ALKPA---
---
PEGATTHWYHAPQ
P
VVTPEEEE
L
RK
L
AQL
L
RY
S
SN
I
A
L
MC
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
IVHA
L
R
G
KE
HV
E
YD
N
P
YDV
GM
T
G
L
I
G
FSSGFHT
M
M
NAD
T
L
VL
L
G
T
Q
F
PY
R
A------
F
Y
P
T
D
A
KI
I
Q
IDI
N
P
A
S
I
GAHSKVD
M
A
L
VGD
IKST
L
RA
LL
PL
V
EEKTDRK
F
L
D
--
--
-
-
K
ALEDY
R
DARKGLDDLAKPS
E
----------------------------
K
A
IHPQYLAQQ
I
SH
----
FAADDAIF
T
C
DVG
TP
T
V
W
AA
RY
-
LKMNG
K
R
RL
L
G
S
F
--------
NH
G
S
M
A
N
AM
P
Q
A
L
GA
QA
T
E
P
ERQ
VV
A
MC
GDG
GFS
M
LMG
D
FL
S
VM
Q
MK
LPV
K
I
I
VF
NN
SV
LG
F
V
A
-
--ME
M
KAGGYLTDGTELHD
-----------
TN
F
AR
I
A
E
A
C
G
IT
G
IR
V
EKAS
E
VDE
AL
QRAFSI
---
DG
P
VL
V
D
V
V
VA
KE
--------
E
LAI
P
P
Q
IK
fig|585057.6.peg.899
Escherichia coli IAI39 (9-539/572)
I
A
KT
L
ESA
GV
KR
I
W
G
VT
G
DS
L
NG
L
S
D
S
L
NRM
-
G
T
I
E
W
M
ST
RHE
E
V
A
AFA
A
G
A
E
A
QLS
G
E
L
A
V
--
C
AGS
C
GPG
N
LH
L
I
N
GL
F
D
C
HR
N
HV
P
VL
A
I
A
A
HIPSSE
IG
--
S
G
Y
FQE
T
H
PQ
--------
ELFRECS
H
YCE
LV
SSP
E
Q
I
P
QV
L
AI
A
MRK
A
V
L
-
N
R
-
G
V
S
V
V
V
LP
G
DV
ALKPA---
---
PEGATTHWYHAPQ
P
VVTPEEEE
L
RK
L
AQL
L
RY
S
SN
I
A
L
MC
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
IVHA
L
R
G
KE
HV
E
YD
N
P
YDV
GM
T
G
L
I
G
FSSGFHT
M
M
NAD
T
L
VL
L
G
T
Q
F
PY
R
A------
F
Y
P
T
D
A
KI
I
Q
IDI
N
P
A
S
I
GAHSKVD
M
A
L
VGD
IKST
L
RA
LL
PL
V
EEKTDRK
F
L
D
--
--
-
-
K
ALEDY
R
DARKGLDDLAKPS
E
----------------------------
K
A
IHPQYLAQQ
I
SH
----
FAADDAIF
T
C
DVG
TP
T
V
W
AA
RY
-
LKMNG
K
R
RL
L
G
S
F
--------
NH
G
S
M
A
N
AM
P
Q
A
L
GA
QA
T
E
P
ERQ
VV
A
MC
GDG
GFS
M
LMG
D
FL
S
VM
Q
MK
LPV
K
I
I
VF
NN
SV
LG
F
V
A
-
--ME
M
KAGGYLTDGTELHD
-----------
TN
F
AR
I
A
E
A
C
G
IT
G
IR
V
EKAS
E
VDE
AL
QRAFSI
---
DG
P
VL
V
D
V
V
VA
KE
--------
E
LAI
P
P
Q
IK
fig|749527.3.peg.105
Escherichia coli MS 21-1 (9-539/572)
I
A
KT
L
ESA
GV
KR
I
W
G
VT
G
DS
L
NG
L
S
D
S
L
NRM
-
G
T
I
E
W
M
ST
RHE
E
V
A
AFA
A
G
A
E
A
QLS
G
E
L
A
V
--
C
AGS
C
GPG
N
LH
L
I
N
GL
F
D
C
HR
N
HV
P
VL
A
I
A
A
HIPSSE
IG
--
S
G
Y
FQE
T
H
PQ
--------
ELFRECS
H
YCE
LV
SSP
E
Q
I
P
QV
L
AI
A
MRK
A
V
L
-
N
R
-
G
V
S
V
V
V
LP
G
DV
ALKPA---
---
PEGATTHWYHAPQ
P
VVTPEEEE
L
RK
L
AQL
L
RY
S
SN
I
A
L
MC
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
IVHA
L
R
G
KE
HV
E
YD
N
P
YDV
GM
T
G
L
I
G
FSSGFHT
M
M
NAD
T
L
VL
L
G
T
Q
F
PY
R
A------
F
Y
P
T
D
A
KI
I
Q
IDI
N
P
A
S
I
GAHSKVD
M
A
L
VGD
IKST
L
RA
LL
PL
V
EEKTDRK
F
L
D
--
--
-
-
K
ALEDY
R
DARKGLDDLAKPS
E
----------------------------
K
A
IHPQYLAQQ
I
SH
----
FAADDAIF
T
C
DVG
TP
T
V
W
AA
RY
-
LKMNG
K
R
RL
L
G
S
F
--------
NH
G
S
M
A
N
AM
P
Q
A
L
GA
QA
T
E
P
ERQ
VV
A
MC
GDG
GFS
M
LMG
D
FL
S
VM
Q
MK
LPV
K
I
I
VF
NN
SV
LG
F
V
A
-
--ME
M
KAGGYLTDGTELHD
-----------
TN
F
AR
I
A
E
A
C
G
IT
G
IR
V
EKAS
E
VDE
AL
QRAFSI
---
DG
P
VL
V
D
V
V
VA
KE
--------
E
LAI
P
P
Q
IK
fig|439855.10.peg.1057
Escherichia coli SMS-3-5 (9-539/572)
I
A
KT
L
ESA
GV
KR
I
W
G
VT
G
DS
L
NG
L
S
D
S
L
NRM
-
G
T
I
E
W
M
ST
RHE
E
V
A
AFA
A
G
A
E
A
QLS
G
E
L
A
V
--
C
AGS
C
GPG
N
LH
L
I
N
GL
F
D
C
HR
N
HV
P
VL
A
I
A
A
HIPSSE
IG
--
S
G
Y
FQE
T
H
PQ
--------
ELFRECS
H
YCE
LV
SSP
E
Q
I
P
QV
L
AI
A
MRK
A
V
L
-
N
R
-
G
V
S
V
V
V
LP
G
DV
ALKPA---
---
PEGATTHWYHAPQ
P
VVTPEEEE
L
RK
L
AQL
L
RY
S
SN
I
A
L
MC
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
IVHA
L
R
G
KE
HV
E
YD
N
P
YDV
GM
T
G
L
I
G
FSSGFHT
M
M
NAD
T
L
VL
L
G
T
Q
F
PY
R
A------
F
Y
P
T
D
A
KI
I
Q
IDI
N
P
A
S
I
GAHSKVD
M
A
L
VGD
IKST
L
RA
LL
PL
V
EEKTDRK
F
L
D
--
--
-
-
K
ALEDY
R
DARKGLDDLAKPS
E
----------------------------
K
A
IHPQYLAQQ
I
SH
----
FAADDAIF
T
C
DVG
TP
T
V
W
AA
RY
-
LKMNG
K
R
RL
L
G
S
F
--------
NH
G
S
M
A
N
AM
P
Q
A
L
GA
QA
T
E
P
ERQ
VV
A
MC
GDG
GFS
M
LMG
D
FL
S
VM
Q
MK
LPV
K
I
I
VF
NN
SV
LG
F
V
A
-
--ME
M
KAGGYLTDGTELHD
-----------
TN
F
AR
I
A
E
A
C
G
IT
G
IR
V
EKAS
E
VDE
AL
QRAFSI
---
DG
P
VL
V
D
V
V
VA
KE
--------
E
LAI
P
P
Q
IK
fig|340186.3.peg.2513
Escherichia coli E110019 (9-539/572)
I
A
KT
L
ESA
GV
KR
I
W
G
VT
G
DS
L
NG
L
S
D
S
L
NRM
-
G
T
I
E
W
M
ST
RHE
E
V
A
AFA
A
G
A
E
A
QLS
G
E
L
A
V
--
C
AGS
C
GPG
N
LH
L
I
N
GL
F
D
C
HR
N
HV
P
VL
A
I
A
A
HIPSSE
IG
--
S
G
Y
FQE
T
H
PQ
--------
ELFRECS
H
YCE
LV
SSP
E
Q
I
P
QV
L
AI
A
MRK
A
V
L
-
N
R
-
G
V
S
V
V
V
LP
G
DV
ALKPA---
---
PEGATTHWYHAPQ
P
VVTPEEEE
L
RK
L
AQL
L
RY
S
SN
I
A
L
MC
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
IVHA
L
R
G
KE
HV
E
YD
N
P
YDV
GM
T
G
L
I
G
FSSGFHT
M
M
NAD
T
L
VL
L
G
T
Q
F
PY
R
A------
F
Y
P
T
D
A
KI
I
Q
IDI
N
P
A
S
I
GAHSKVD
M
A
L
VGD
IKST
L
RA
LL
PL
V
EEKADRK
F
L
D
--
--
-
-
K
ALEDY
R
DARKGLDDLAKPS
E
----------------------------
K
A
IHPQYLAQQ
I
SH
----
FAADDAIF
T
C
DVG
TP
T
V
W
AA
RY
-
LKMNG
K
R
RL
L
G
S
F
--------
NH
G
S
M
A
N
AM
P
Q
A
L
GA
QA
T
E
P
ERQ
VV
A
MC
GDG
GFS
M
LMG
D
FL
S
VV
Q
MK
LPV
K
IV
VF
NN
SV
LG
F
V
A
-
--ME
M
KAGGYLTDGTELHD
-----------
TN
F
AR
I
A
E
A
C
G
IT
G
IR
V
EKAS
E
VDE
AL
QRAFSI
---
DG
P
VL
V
D
V
V
VA
KE
--------
E
LAI
P
P
Q
IK
fig|340186.5.peg.2597
Escherichia coli E110019 (9-539/572)
I
A
KT
L
ESA
GV
KR
I
W
G
VT
G
DS
L
NG
L
S
D
S
L
NRM
-
G
T
I
E
W
M
ST
RHE
E
V
A
AFA
A
G
A
E
A
QLS
G
E
L
A
V
--
C
AGS
C
GPG
N
LH
L
I
N
GL
F
D
C
HR
N
HV
P
VL
A
I
A
A
HIPSSE
IG
--
S
G
Y
FQE
T
H
PQ
--------
ELFRECS
H
YCE
LV
SSP
E
Q
I
P
QV
L
AI
A
MRK
A
V
L
-
N
R
-
G
V
S
V
V
V
LP
G
DV
ALKPA---
---
PEGATTHWYHAPQ
P
VVTPEEEE
L
RK
L
AQL
L
RY
S
SN
I
A
L
MC
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
IVHA
L
R
G
KE
HV
E
YD
N
P
YDV
GM
T
G
L
I
G
FSSGFHT
M
M
NAD
T
L
VL
L
G
T
Q
F
PY
R
A------
F
Y
P
T
D
A
KI
I
Q
IDI
N
P
A
S
I
GAHSKVD
M
A
L
VGD
IKST
L
RA
LL
PL
V
EEKADRK
F
L
D
--
--
-
-
K
ALEDY
R
DARKGLDDLAKPS
E
----------------------------
K
A
IHPQYLAQQ
I
SH
----
FAADDAIF
T
C
DVG
TP
T
V
W
AA
RY
-
LKMNG
K
R
RL
L
G
S
F
--------
NH
G
S
M
A
N
AM
P
Q
A
L
GA
QA
T
E
P
ERQ
VV
A
MC
GDG
GFS
M
LMG
D
FL
S
VV
Q
MK
LPV
K
IV
VF
NN
SV
LG
F
V
A
-
--ME
M
KAGGYLTDGTELHD
-----------
TN
F
AR
I
A
E
A
C
G
IT
G
IR
V
EKAS
E
VDE
AL
QRAFSI
---
DG
P
VL
V
D
V
V
VA
KE
--------
E
LAI
P
P
Q
IK
fig|340185.3.peg.2782
Escherichia coli E22 (9-539/572)
I
A
KT
L
ESA
GV
KR
I
W
G
VT
G
DS
L
NG
L
S
D
S
L
NRM
-
G
T
I
E
W
M
ST
RHE
E
V
A
AFA
A
G
A
E
A
QLS
G
E
L
A
V
--
C
AGS
C
GPG
N
LH
L
I
N
GL
F
D
C
HR
N
HV
P
VL
A
I
A
A
HIPSSE
IG
--
S
G
Y
FQE
T
H
PQ
--------
ELFRECS
H
YCE
LV
SSP
E
Q
I
P
QV
L
AI
A
MRK
A
V
L
-
N
R
-
G
V
S
V
V
V
LP
G
DV
ALKPA---
---
PEGATTHWYHAPQ
P
VVTPEEEE
L
RK
L
AQL
L
RY
S
SN
I
A
L
MC
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
IVHA
L
R
G
KE
HV
E
YD
N
P
YDV
GM
T
G
L
I
G
FSSGFHT
M
M
NAD
T
L
VL
L
G
T
Q
F
PY
R
A------
F
Y
P
T
D
A
KI
I
Q
IDI
N
P
A
S
I
GAHSKVD
M
A
L
VGD
IKST
L
RA
LL
PL
V
EEKADRK
F
L
D
--
--
-
-
K
ALEDY
R
DARKGLDDLAKPS
E
----------------------------
K
A
IHPQYLAQQ
I
SH
----
FAADDAIF
T
C
DVG
TP
T
V
W
AA
RY
-
LKMNG
K
R
RL
L
G
S
F
--------
NH
G
S
M
A
N
AM
P
Q
A
L
GA
QA
T
E
P
ERQ
VV
A
MC
GDG
GFS
M
LMG
D
FL
S
VV
Q
MK
LPV
K
IV
VF
NN
SV
LG
F
V
A
-
--ME
M
KAGGYLTDGTELHD
-----------
TN
F
AR
I
A
E
A
C
G
IT
G
IR
V
EKAS
E
VDE
AL
QRAFSI
---
DG
P
VL
V
D
V
V
VA
KE
--------
E
LAI
P
P
Q
IK
fig|340185.4.peg.2932
Escherichia coli E22 (9-539/572)
I
A
KT
L
ESA
GV
KR
I
W
G
VT
G
DS
L
NG
L
S
D
S
L
NRM
-
G
T
I
E
W
M
ST
RHE
E
V
A
AFA
A
G
A
E
A
QLS
G
E
L
A
V
--
C
AGS
C
GPG
N
LH
L
I
N
GL
F
D
C
HR
N
HV
P
VL
A
I
A
A
HIPSSE
IG
--
S
G
Y
FQE
T
H
PQ
--------
ELFRECS
H
YCE
LV
SSP
E
Q
I
P
QV
L
AI
A
MRK
A
V
L
-
N
R
-
G
V
S
V
V
V
LP
G
DV
ALKPA---
---
PEGATTHWYHAPQ
P
VVTPEEEE
L
RK
L
AQL
L
RY
S
SN
I
A
L
MC
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
IVHA
L
R
G
KE
HV
E
YD
N
P
YDV
GM
T
G
L
I
G
FSSGFHT
M
M
NAD
T
L
VL
L
G
T
Q
F
PY
R
A------
F
Y
P
T
D
A
KI
I
Q
IDI
N
P
A
S
I
GAHSKVD
M
A
L
VGD
IKST
L
RA
LL
PL
V
EEKADRK
F
L
D
--
--
-
-
K
ALEDY
R
DARKGLDDLAKPS
E
----------------------------
K
A
IHPQYLAQQ
I
SH
----
FAADDAIF
T
C
DVG
TP
T
V
W
AA
RY
-
LKMNG
K
R
RL
L
G
S
F
--------
NH
G
S
M
A
N
AM
P
Q
A
L
GA
QA
T
E
P
ERQ
VV
A
MC
GDG
GFS
M
LMG
D
FL
S
VV
Q
MK
LPV
K
IV
VF
NN
SV
LG
F
V
A
-
--ME
M
KAGGYLTDGTELHD
-----------
TN
F
AR
I
A
E
A
C
G
IT
G
IR
V
EKAS
E
VDE
AL
QRAFSI
---
DG
P
VL
V
D
V
V
VA
KE
--------
E
LAI
P
P
Q
IK
fig|562.375.peg.4520
Escherichia coli EC4100B (9-539/572)
I
A
KT
L
ESA
GV
KR
I
W
G
VT
G
DS
L
NG
L
S
D
S
L
NRM
-
G
T
I
E
W
M
ST
RHE
E
V
A
AFA
A
G
A
E
A
QLS
G
E
L
A
V
--
C
AGS
C
GPG
N
LH
L
I
N
GL
F
D
C
HR
N
HV
P
VL
A
I
A
A
HIPSSE
IG
--
S
G
Y
FQE
T
H
PQ
--------
ELFRECS
H
YCE
LV
SSP
E
Q
I
P
QV
L
AI
A
MRK
A
V
L
-
N
R
-
G
V
S
V
V
V
LP
G
DV
ALKPA---
---
PEGATTHWYHAPQ
P
VVTPEEEE
L
RK
L
AQL
L
RY
S
SN
I
A
L
MC
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
IVHA
L
R
G
KE
HV
E
YD
N
P
YDV
GM
T
G
L
I
G
FSSGFHT
M
M
NAD
T
L
VL
L
G
T
Q
F
PY
R
A------
F
Y
P
T
D
A
KI
I
Q
IDI
N
P
A
S
I
GAHSKVD
M
A
L
VGD
IKST
L
RA
LL
PL
V
EEKADRK
F
L
D
--
--
-
-
K
ALEDY
R
DARKGLDDLAKPS
E
----------------------------
K
A
IHPQYLAQQ
I
SH
----
FAADDAIF
T
C
DVG
TP
T
V
W
AA
RY
-
LKMNG
K
R
RL
L
G
S
F
--------
NH
G
S
M
A
N
AM
P
Q
A
L
GA
QA
T
E
P
ERQ
VV
A
MC
GDG
GFS
M
LMG
D
FL
S
VV
Q
MK
LPV
K
IV
VF
NN
SV
LG
F
V
A
-
--ME
M
KAGGYLTDGTELHD
-----------
TN
F
AR
I
A
E
A
C
G
IT
G
IR
V
EKAS
E
VDE
AL
QRAFSI
---
DG
P
VL
V
D
V
V
VA
KE
--------
E
LAI
P
P
Q
IK
fig|316401.4.peg.1083
Escherichia coli ETEC H10407 (9-539/572)
I
A
KT
L
ESA
GV
KR
I
W
G
VT
G
DS
L
NG
L
S
D
S
L
NRM
-
G
T
I
E
W
M
ST
RHE
E
V
A
AFA
A
G
A
E
A
QLS
G
E
L
A
V
--
C
AGS
C
GPG
N
LH
L
I
N
GL
F
D
C
HR
N
HV
P
VL
A
I
A
A
HIPSSE
IG
--
S
G
Y
FQE
T
H
PQ
--------
ELFRECS
H
YCE
LV
SSP
E
Q
I
P
QV
L
AI
A
MRK
A
V
L
-
N
R
-
G
V
S
V
V
V
LP
G
DV
ALKPA---
---
PEGATTHWYHAPQ
P
VVTPEEEE
L
RK
L
AQL
L
RY
S
SN
I
A
L
MC
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
IVHA
L
R
G
KE
HV
E
YD
N
P
YDV
GM
T
G
L
I
G
FSSGFHT
M
M
NAD
T
L
VL
L
G
T
Q
F
PY
R
A------
F
Y
P
T
D
A
KI
I
Q
IDI
N
P
A
S
I
GAHSKVD
M
A
L
VGD
IKST
L
RA
LL
PL
V
EEKADRK
F
L
D
--
--
-
-
K
ALEDY
R
DARKGLDDLAKPS
E
----------------------------
K
A
IHPQYLAQQ
I
SH
----
FAADDAIF
T
C
DVG
TP
T
V
W
AA
RY
-
LKMNG
K
R
RL
L
G
S
F
--------
NH
G
S
M
A
N
AM
P
Q
A
L
GA
QA
T
E
P
ERQ
VV
A
MC
GDG
GFS
M
LMG
D
FL
S
VV
Q
MK
LPV
K
IV
VF
NN
SV
LG
F
V
A
-
--ME
M
KAGGYLTDGTELHD
-----------
TN
F
AR
I
A
E
A
C
G
IT
G
IR
V
EKAS
E
VDE
AL
QRAFSI
---
DG
P
VL
V
D
V
V
VA
KE
--------
E
LAI
P
P
Q
IK
fig|331112.3.peg.904
Escherichia coli HS (9-539/572)
I
A
KT
L
ESA
GV
KR
I
W
G
VT
G
DS
L
NG
L
S
D
S
L
NRM
-
G
T
I
E
W
M
ST
RHE
E
V
A
AFA
A
G
A
E
A
QLS
G
E
L
A
V
--
C
AGS
C
GPG
N
LH
L
I
N
GL
F
D
C
HR
N
HV
P
VL
A
I
A
A
HIPSSE
IG
--
S
G
Y
FQE
T
H
PQ
--------
ELFRECS
H
YCE
LV
SSP
E
Q
I
P
QV
L
AI
A
MRK
A
V
L
-
N
R
-
G
V
S
V
V
V
LP
G
DV
ALKPA---
---
PEGATTHWYHAPQ
P
VVTPEEEE
L
RK
L
AQL
L
RY
S
SN
I
A
L
MC
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
IVHA
L
R
G
KE
HV
E
YD
N
P
YDV
GM
T
G
L
I
G
FSSGFHT
M
M
NAD
T
L
VL
L
G
T
Q
F
PY
R
A------
F
Y
P
T
D
A
KI
I
Q
IDI
N
P
A
S
I
GAHSKVD
M
A
L
VGD
IKST
L
RA
LL
PL
V
EEKADRK
F
L
D
--
--
-
-
K
ALEDY
R
DARKGLDDLAKPS
E
----------------------------
K
A
IHPQYLAQQ
I
SH
----
FAADDAIF
T
C
DVG
TP
T
V
W
AA
RY
-
LKMNG
K
R
RL
L
G
S
F
--------
NH
G
S
M
A
N
AM
P
Q
A
L
GA
QA
T
E
P
ERQ
VV
A
MC
GDG
GFS
M
LMG
D
FL
S
VV
Q
MK
LPV
K
IV
VF
NN
SV
LG
F
V
A
-
--ME
M
KAGGYLTDGTELHD
-----------
TN
F
AR
I
A
E
A
C
G
IT
G
IR
V
EKAS
E
VDE
AL
QRAFSI
---
DG
P
VL
V
D
V
V
VA
KE
--------
E
LAI
P
P
Q
IK
fig|331112.6.peg.943
Escherichia coli HS (9-539/572)
I
A
KT
L
ESA
GV
KR
I
W
G
VT
G
DS
L
NG
L
S
D
S
L
NRM
-
G
T
I
E
W
M
ST
RHE
E
V
A
AFA
A
G
A
E
A
QLS
G
E
L
A
V
--
C
AGS
C
GPG
N
LH
L
I
N
GL
F
D
C
HR
N
HV
P
VL
A
I
A
A
HIPSSE
IG
--
S
G
Y
FQE
T
H
PQ
--------
ELFRECS
H
YCE
LV
SSP
E
Q
I
P
QV
L
AI
A
MRK
A
V
L
-
N
R
-
G
V
S
V
V
V
LP
G
DV
ALKPA---
---
PEGATTHWYHAPQ
P
VVTPEEEE
L
RK
L
AQL
L
RY
S
SN
I
A
L
MC
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
IVHA
L
R
G
KE
HV
E
YD
N
P
YDV
GM
T
G
L
I
G
FSSGFHT
M
M
NAD
T
L
VL
L
G
T
Q
F
PY
R
A------
F
Y
P
T
D
A
KI
I
Q
IDI
N
P
A
S
I
GAHSKVD
M
A
L
VGD
IKST
L
RA
LL
PL
V
EEKADRK
F
L
D
--
--
-
-
K
ALEDY
R
DARKGLDDLAKPS
E
----------------------------
K
A
IHPQYLAQQ
I
SH
----
FAADDAIF
T
C
DVG
TP
T
V
W
AA
RY
-
LKMNG
K
R
RL
L
G
S
F
--------
NH
G
S
M
A
N
AM
P
Q
A
L
GA
QA
T
E
P
ERQ
VV
A
MC
GDG
GFS
M
LMG
D
FL
S
VV
Q
MK
LPV
K
IV
VF
NN
SV
LG
F
V
A
-
--ME
M
KAGGYLTDGTELHD
-----------
TN
F
AR
I
A
E
A
C
G
IT
G
IR
V
EKAS
E
VDE
AL
QRAFSI
---
DG
P
VL
V
D
V
V
VA
KE
--------
E
LAI
P
P
Q
IK
fig|749537.3.peg.4363
Escherichia coli MS 115-1 (9-539/572)
I
A
KT
L
ESA
GV
KR
I
W
G
VT
G
DS
L
NG
L
S
D
S
L
NRM
-
G
T
I
E
W
M
ST
RHE
E
V
A
AFA
A
G
A
E
A
QLS
G
E
L
A
V
--
C
AGS
C
GPG
N
LH
L
I
N
GL
F
D
C
HR
N
HV
P
VL
A
I
A
A
HIPSSE
IG
--
S
G
Y
FQE
T
H
PQ
--------
ELFRECS
H
YCE
LV
SSP
E
Q
I
P
QV
L
AI
A
MRK
A
V
L
-
N
R
-
G
V
S
V
V
V
LP
G
DV
ALKPA---
---
PEGATTHWYHAPQ
P
VVTPEEEE
L
RK
L
AQL
L
RY
S
SN
I
A
L
MC
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
IVHA
L
R
G
KE
HV
E
YD
N
P
YDV
GM
T
G
L
I
G
FSSGFHT
M
M
NAD
T
L
VL
L
G
T
Q
F
PY
R
A------
F
Y
P
T
D
A
KI
I
Q
IDI
N
P
A
S
I
GAHSKVD
M
A
L
VGD
IKST
L
RA
LL
PL
V
EEKADRK
F
L
D
--
--
-
-
K
ALEDY
R
DARKGLDDLAKPS
E
----------------------------
K
A
IHPQYLAQQ
I
SH
----
FAADDAIF
T
C
DVG
TP
T
V
W
AA
RY
-
LKMNG
K
R
RL
L
G
S
F
--------
NH
G
S
M
A
N
AM
P
Q
A
L
GA
QA
T
E
P
ERQ
VV
A
MC
GDG
GFS
M
LMG
D
FL
S
VV
Q
MK
LPV
K
IV
VF
NN
SV
LG
F
V
A
-
--ME
M
KAGGYLTDGTELHD
-----------
TN
F
AR
I
A
E
A
C
G
IT
G
IR
V
EKAS
E
VDE
AL
QRAFSI
---
DG
P
VL
V
D
V
V
VA
KE
--------
E
LAI
P
P
Q
IK
fig|679205.4.peg.3836
Escherichia coli MS 124-1 (9-539/572)
I
A
KT
L
ESA
GV
KR
I
W
G
VT
G
DS
L
NG
L
S
D
S
L
NRM
-
G
T
I
E
W
M
ST
RHE
E
V
A
AFA
A
G
A
E
A
QLS
G
E
L
A
V
--
C
AGS
C
GPG
N
LH
L
I
N
GL
F
D
C
HR
N
HV
P
VL
A
I
A
A
HIPSSE
IG
--
S
G
Y
FQE
T
H
PQ
--------
ELFRECS
H
YCE
LV
SSP
E
Q
I
P
QV
L
AI
A
MRK
A
V
L
-
N
R
-
G
V
S
V
V
V
LP
G
DV
ALKPA---
---
PEGATTHWYHAPQ
P
VVTPEEEE
L
RK
L
AQL
L
RY
S
SN
I
A
L
MC
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
IVHA
L
R
G
KE
HV
E
YD
N
P
YDV
GM
T
G
L
I
G
FSSGFHT
M
M
NAD
T
L
VL
L
G
T
Q
F
PY
R
A------
F
Y
P
T
D
A
KI
I
Q
IDI
N
P
A
S
I
GAHSKVD
M
A
L
VGD
IKST
L
RA
LL
PL
V
EEKADRK
F
L
D
--
--
-
-
K
ALEDY
R
DARKGLDDLAKPS
E
----------------------------
K
A
IHPQYLAQQ
I
SH
----
FAADDAIF
T
C
DVG
TP
T
V
W
AA
RY
-
LKMNG
K
R
RL
L
G
S
F
--------
NH
G
S
M
A
N
AM
P
Q
A
L
GA
QA
T
E
P
ERQ
VV
A
MC
GDG
GFS
M
LMG
D
FL
S
VV
Q
MK
LPV
K
IV
VF
NN
SV
LG
F
V
A
-
--ME
M
KAGGYLTDGTELHD
-----------
TN
F
AR
I
A
E
A
C
G
IT
G
IR
V
EKAS
E
VDE
AL
QRAFSI
---
DG
P
VL
V
D
V
V
VA
KE
--------
E
LAI
P
P
Q
IK
fig|749533.3.peg.540
Escherichia coli MS 84-1 (9-539/572)
I
A
KT
L
ESA
GV
KR
I
W
G
VT
G
DS
L
NG
L
S
D
S
L
NRM
-
G
T
I
E
W
M
ST
RHE
E
V
A
AFA
A
G
A
E
A
QLS
G
E
L
A
V
--
C
AGS
C
GPG
N
LH
L
I
N
GL
F
D
C
HR
N
HV
P
VL
A
I
A
A
HIPSSE
IG
--
S
G
Y
FQE
T
H
PQ
--------
ELFRECS
H
YCE
LV
SSP
E
Q
I
P
QV
L
AI
A
MRK
A
V
L
-
N
R
-
G
V
S
V
V
V
LP
G
DV
ALKPA---
---
PEGATTHWYHAPQ
P
VVTPEEEE
L
RK
L
AQL
L
RY
S
SN
I
A
L
MC
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
IVHA
L
R
G
KE
HV
E
YD
N
P
YDV
GM
T
G
L
I
G
FSSGFHT
M
M
NAD
T
L
VL
L
G
T
Q
F
PY
R
A------
F
Y
P
T
D
A
KI
I
Q
IDI
N
P
A
S
I
GAHSKVD
M
A
L
VGD
IKST
L
RA
LL
PL
V
EEKADRK
F
L
D
--
--
-
-
K
ALEDY
R
DARKGLDDLAKPS
E
----------------------------
K
A
IHPQYLAQQ
I
SH
----
FAADDAIF
T
C
DVG
TP
T
V
W
AA
RY
-
LKMNG
K
R
RL
L
G
S
F
--------
NH
G
S
M
A
N
AM
P
Q
A
L
GA
QA
T
E
P
ERQ
VV
A
MC
GDG
GFS
M
LMG
D
FL
S
VV
Q
MK
LPV
K
IV
VF
NN
SV
LG
F
V
A
-
--ME
M
KAGGYLTDGTELHD
-----------
TN
F
AR
I
A
E
A
C
G
IT
G
IR
V
EKAS
E
VDE
AL
QRAFSI
---
DG
P
VL
V
D
V
V
VA
KE
--------
E
LAI
P
P
Q
IK
fig|585395.4.peg.964
Escherichia coli O103:H2 str. 12009 (9-539/572)
I
A
KT
L
ESA
GV
KR
I
W
G
VT
G
DS
L
NG
L
S
D
S
L
NRM
-
G
T
I
E
W
M
ST
RHE
E
V
A
AFA
A
G
A
E
A
QLS
G
E
L
A
V
--
C
AGS
C
GPG
N
LH
L
I
N
GL
F
D
C
HR
N
HV
P
VL
A
I
A
A
HIPSSE
IG
--
S
G
Y
FQE
T
H
PQ
--------
ELFRECS
H
YCE
LV
SSP
E
Q
I
P
QV
L
AI
A
MRK
A
V
L
-
N
R
-
G
V
S
V
V
V
LP
G
DV
ALKPA---
---
PEGATTHWYHAPQ
P
VVTPEEEE
L
RK
L
AQL
L
RY
S
SN
I
A
L
MC
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
IVHA
L
R
G
KE
HV
E
YD
N
P
YDV
GM
T
G
L
I
G
FSSGFHT
M
M
NAD
T
L
VL
L
G
T
Q
F
PY
R
A------
F
Y
P
T
D
A
KI
I
Q
IDI
N
P
A
S
I
GAHSKVD
M
A
L
VGD
IKST
L
RA
LL
PL
V
EEKADRK
F
L
D
--
--
-
-
K
ALEDY
R
DARKGLDDLAKPS
E
----------------------------
K
A
IHPQYLAQQ
I
SH
----
FAADDAIF
T
C
DVG
TP
T
V
W
AA
RY
-
LKMNG
K
R
RL
L
G
S
F
--------
NH
G
S
M
A
N
AM
P
Q
A
L
GA
QA
T
E
P
ERQ
VV
A
MC
GDG
GFS
M
LMG
D
FL
S
VV
Q
MK
LPV
K
IV
VF
NN
SV
LG
F
V
A
-
--ME
M
KAGGYLTDGTELHD
-----------
TN
F
AR
I
A
E
A
C
G
IT
G
IR
V
EKAS
E
VDE
AL
QRAFSI
---
DG
P
VL
V
D
V
V
VA
KE
--------
E
LAI
P
P
Q
IK
fig|573235.3.peg.1019
Escherichia coli O26:H11 str. 11368 (9-539/572)
I
A
KT
L
ESA
GV
KR
I
W
G
VT
G
DS
L
NG
L
S
D
S
L
NRM
-
G
T
I
E
W
M
ST
RHE
E
V
A
AFA
A
G
A
E
A
QLS
G
E
L
A
V
--
C
AGS
C
GPG
N
LH
L
I
N
GL
F
D
C
HR
N
HV
P
VL
A
I
A
A
HIPSSE
IG
--
S
G
Y
FQE
T
H
PQ
--------
ELFRECS
H
YCE
LV
SSP
E
Q
I
P
QV
L
AI
A
MRK
A
V
L
-
N
R
-
G
V
S
V
V
V
LP
G
DV
ALKPA---
---
PEGATTHWYHAPQ
P
VVTPEEEE
L
RK
L
AQL
L
RY
S
SN
I
A
L
MC
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
IVHA
L
R
G
KE
HV
E
YD
N
P
YDV
GM
T
G
L
I
G
FSSGFHT
M
M
NAD
T
L
VL
L
G
T
Q
F
PY
R
A------
F
Y
P
T
D
A
KI
I
Q
IDI
N
P
A
S
I
GAHSKVD
M
A
L
VGD
IKST
L
RA
LL
PL
V
EEKADRK
F
L
D
--
--
-
-
K
ALEDY
R
DARKGLDDLAKPS
E
----------------------------
K
A
IHPQYLAQQ
I
SH
----
FAADDAIF
T
C
DVG
TP
T
V
W
AA
RY
-
LKMNG
K
R
RL
L
G
S
F
--------
NH
G
S
M
A
N
AM
P
Q
A
L
GA
QA
T
E
P
ERQ
VV
A
MC
GDG
GFS
M
LMG
D
FL
S
VV
Q
MK
LPV
K
IV
VF
NN
SV
LG
F
V
A
-
--ME
M
KAGGYLTDGTELHD
-----------
TN
F
AR
I
A
E
A
C
G
IT
G
IR
V
EKAS
E
VDE
AL
QRAFSI
---
DG
P
VL
V
D
V
V
VA
KE
--------
E
LAI
P
P
Q
IK
fig|409438.11.peg.1059
Escherichia coli SE11 (9-539/572)
I
A
KT
L
ESA
GV
KR
I
W
G
VT
G
DS
L
NG
L
S
D
S
L
NRM
-
G
T
I
E
W
M
ST
RHE
E
V
A
AFA
A
G
A
E
A
QLS
G
E
L
A
V
--
C
AGS
C
GPG
N
LH
L
I
N
GL
F
D
C
HR
N
HV
P
VL
A
I
A
A
HIPSSE
IG
--
S
G
Y
FQE
T
H
PQ
--------
ELFRECS
H
YCE
LV
SSP
E
Q
I
P
QV
L
AI
A
MRK
A
V
L
-
N
R
-
G
V
S
V
V
V
LP
G
DV
ALKPA---
---
PEGATTHWYHAPQ
P
VVTPEEEE
L
RK
L
AQL
L
RY
S
SN
I
A
L
MC
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
IVHA
L
R
G
KE
HV
E
YD
N
P
YDV
GM
T
G
L
I
G
FSSGFHT
M
M
NAD
T
L
VL
L
G
T
Q
F
PY
R
A------
F
Y
P
T
D
A
KI
I
Q
IDI
N
P
A
S
I
GAHSKVD
M
A
L
VGD
IKST
L
RA
LL
PL
V
EEKADRK
F
L
D
--
--
-
-
K
ALEDY
R
DARKGLDDLAKPS
E
----------------------------
K
A
IHPQYLAQQ
I
SH
----
FAADDAIF
T
C
DVG
TP
T
V
W
AA
RY
-
LKMNG
K
R
RL
L
G
S
F
--------
NH
G
S
M
A
N
AM
P
Q
A
L
GA
QA
T
E
P
ERQ
VV
A
MC
GDG
GFS
M
LMG
D
FL
S
VV
Q
MK
LPV
K
IV
VF
NN
SV
LG
F
V
A
-
--ME
M
KAGGYLTDGTELHD
-----------
TN
F
AR
I
A
E
A
C
G
IT
G
IR
V
EKAS
E
VDE
AL
QRAFSI
---
DG
P
VL
V
D
V
V
VA
KE
--------
E
LAI
P
P
Q
IK
fig|585396.4.peg.977
Escherichia coli O111:H- str. 11128 (9-539/572)
I
A
KT
L
ESA
GV
KR
I
W
G
VT
G
DS
L
NG
L
S
D
S
L
NRM
-
G
T
I
E
W
M
ST
RHE
E
V
A
AFA
A
G
A
E
A
QLS
G
E
L
A
V
--
C
AGS
C
GPG
N
LH
L
I
N
GL
F
D
C
HR
N
HV
P
VL
A
I
A
A
HIPSSE
IG
--
S
G
Y
FQE
T
H
PQ
--------
ELFRECS
H
YCE
LV
SSP
E
Q
I
P
QV
L
AI
A
MRK
A
V
L
-
N
R
-
G
V
S
V
V
V
LP
G
DV
ALKPA---
---
PEGATTHWYHTPQ
P
VVTPEEEE
L
RK
L
AQL
L
RY
S
SN
I
A
L
MC
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
IVHA
L
R
G
KE
HV
E
YD
N
P
YDV
GM
T
G
L
I
G
FSSGFHT
M
M
NAD
T
L
VL
L
G
T
Q
F
PY
R
A------
F
Y
P
T
D
A
KI
I
Q
IDI
N
P
A
S
I
GAHSKVD
M
A
L
VGD
IKST
L
RA
LL
PL
V
EEKADRK
F
L
D
--
--
-
-
K
ALEDY
R
DARKGLDDLAKPS
E
----------------------------
K
A
IHPQYLAQQ
I
SH
----
FAADDAIF
T
C
DVG
TP
T
V
W
AA
RY
-
LKMNG
K
R
RL
L
G
S
F
--------
NH
G
S
M
A
N
AM
P
Q
A
L
GA
QA
T
E
P
ERQ
VV
A
MC
GDG
GFS
M
LMG
D
FL
S
VV
Q
MK
LPV
K
IV
VF
NN
SV
LG
F
V
A
-
--ME
M
KAGGYLTDGTELHD
-----------
TN
F
AR
I
A
E
A
C
G
IT
G
IR
V
EKAS
E
VDE
AL
QRAFSI
---
DG
P
VL
V
D
V
V
VA
KE
--------
E
LAI
P
P
Q
IK
fig|562.371.peg.2167
Escherichia coli 1044A (9-539/572)
I
A
KT
L
ESA
GV
KR
I
W
G
VT
G
DS
L
NG
L
S
D
S
L
NRM
-
G
T
I
E
W
M
ST
RHE
E
V
A
AFA
A
G
A
E
A
QLS
G
E
L
A
V
--
C
AGS
C
GPG
N
LH
L
I
N
GL
F
D
C
HR
N
HV
P
VL
A
I
A
A
HIPSSE
IG
--
S
G
Y
FQE
T
H
PQ
--------
ELFRECS
H
YCE
LV
SSP
E
Q
I
P
QV
L
AI
A
MRK
A
V
L
-
N
R
-
G
V
S
V
V
V
LP
G
DV
ALKPA---
---
PEGATTHWYHAPQ
P
VVTPEEEE
L
RK
L
AQL
L
RY
S
SN
I
A
L
MC
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
IVHA
L
R
G
KE
HV
E
YD
N
P
YDV
GM
T
G
L
I
G
FSSGFHT
M
M
NAD
T
L
VL
L
G
T
Q
F
PY
R
A------
F
Y
P
T
D
A
KI
I
Q
IDI
N
P
A
S
I
GAHSKVD
M
A
L
VGD
IKST
L
RA
LL
PL
V
EEKADRK
F
L
D
--
--
-
-
K
ALEDY
R
DARKGLDDLAKPS
E
----------------------------
K
A
IHPQYLAQQ
I
SH
----
FAADDAIF
T
C
DVG
TP
T
V
W
AA
RY
-
LKMNG
K
R
RL
L
G
S
F
--------
NH
G
S
M
A
N
AM
P
Q
A
L
GA
QA
T
E
P
ERQ
VV
A
MC
GDG
GFS
M
LMG
D
FL
S
VV
Q
MK
LPV
K
I
I
VF
NN
SV
LG
F
V
A
-
--ME
M
KAGGYLTDGTELHD
-----------
TN
F
AR
I
A
E
A
C
G
IT
G
IR
V
EKAS
E
IDE
AL
QRAFSI
---
DG
P
VL
V
D
V
V
VA
KE
--------
E
LAI
P
P
Q
IK
fig|562.373.peg.1150
Escherichia coli 1125A (9-539/572)
I
A
KT
L
ESA
GV
KR
I
W
G
VT
G
DS
L
NG
L
S
D
S
L
NRM
-
G
T
I
E
W
M
ST
RHE
E
V
A
AFA
A
G
A
E
A
QLS
G
E
L
A
V
--
C
AGS
C
GPG
N
LH
L
I
N
GL
F
D
C
HR
N
HV
P
VL
A
I
A
A
HIPSSE
IG
--
S
G
Y
FQE
T
H
PQ
--------
ELFRECS
H
YCE
LV
SSP
E
Q
I
P
QV
L
AI
A
MRK
A
V
L
-
N
R
-
G
V
S
V
V
V
LP
G
DV
ALKPA---
---
PEGATTHWYHAPQ
P
VVTPEEEE
L
RK
L
AQL
L
RY
S
SN
I
A
L
MC
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
IVHA
L
R
G
KE
HV
E
YD
N
P
YDV
GM
T
G
L
I
G
FSSGFHT
M
M
NAD
T
L
VL
L
G
T
Q
F
PY
R
A------
F
Y
P
T
D
A
KI
I
Q
IDI
N
P
A
S
I
GAHSKVD
M
A
L
VGD
IKST
L
RA
LL
PL
V
EEKADRK
F
L
D
--
--
-
-
K
ALEDY
R
DARKGLDDLAKPS
E
----------------------------
K
A
IHPQYLAQQ
I
SH
----
FAADDAIF
T
C
DVG
TP
T
V
W
AA
RY
-
LKMNG
K
R
RL
L
G
S
F
--------
NH
G
S
M
A
N
AM
P
Q
A
L
GA
QA
T
E
P
ERQ
VV
A
MC
GDG
GFS
M
LMG
D
FL
S
VV
Q
MK
LPV
K
I
I
VF
NN
SV
LG
F
V
A
-
--ME
M
KAGGYLTDGTELHD
-----------
TN
F
AR
I
A
E
A
C
G
IT
G
IR
V
EKAS
E
IDE
AL
QRAFSI
---
DG
P
VL
V
D
V
V
VA
KE
--------
E
LAI
P
P
Q
IK
fig|562.372.peg.1015
Escherichia coli 1212A (9-539/572)
I
A
KT
L
ESA
GV
KR
I
W
G
VT
G
DS
L
NG
L
S
D
S
L
NRM
-
G
T
I
E
W
M
ST
RHE
E
V
A
AFA
A
G
A
E
A
QLS
G
E
L
A
V
--
C
AGS
C
GPG
N
LH
L
I
N
GL
F
D
C
HR
N
HV
P
VL
A
I
A
A
HIPSSE
IG
--
S
G
Y
FQE
T
H
PQ
--------
ELFRECS
H
YCE
LV
SSP
E
Q
I
P
QV
L
AI
A
MRK
A
V
L
-
N
R
-
G
V
S
V
V
V
LP
G
DV
ALKPA---
---
PEGATTHWYHAPQ
P
VVTPEEEE
L
RK
L
AQL
L
RY
S
SN
I
A
L
MC
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
IVHA
L
R
G
KE
HV
E
YD
N
P
YDV
GM
T
G
L
I
G
FSSGFHT
M
M
NAD
T
L
VL
L
G
T
Q
F
PY
R
A------
F
Y
P
T
D
A
KI
I
Q
IDI
N
P
A
S
I
GAHSKVD
M
A
L
VGD
IKST
L
RA
LL
PL
V
EEKADRK
F
L
D
--
--
-
-
K
ALEDY
R
DARKGLDDLAKPS
E
----------------------------
K
A
IHPQYLAQQ
I
SH
----
FAADDAIF
T
C
DVG
TP
T
V
W
AA
RY
-
LKMNG
K
R
RL
L
G
S
F
--------
NH
G
S
M
A
N
AM
P
Q
A
L
GA
QA
T
E
P
ERQ
VV
A
MC
GDG
GFS
M
LMG
D
FL
S
VV
Q
MK
LPV
K
I
I
VF
NN
SV
LG
F
V
A
-
--ME
M
KAGGYLTDGTELHD
-----------
TN
F
AR
I
A
E
A
C
G
IT
G
IR
V
EKAS
E
IDE
AL
QRAFSI
---
DG
P
VL
V
D
V
V
VA
KE
--------
E
LAI
P
P
Q
IK
fig|562.374.peg.2549
Escherichia coli 536A (9-539/572)
I
A
KT
L
ESA
GV
KR
I
W
G
VT
G
DS
L
NG
L
S
D
S
L
NRM
-
G
T
I
E
W
M
ST
RHE
E
V
A
AFA
A
G
A
E
A
QLS
G
E
L
A
V
--
C
AGS
C
GPG
N
LH
L
I
N
GL
F
D
C
HR
N
HV
P
VL
A
I
A
A
HIPSSE
IG
--
S
G
Y
FQE
T
H
PQ
--------
ELFRECS
H
YCE
LV
SSP
E
Q
I
P
QV
L
AI
A
MRK
A
V
L
-
N
R
-
G
V
S
V
V
V
LP
G
DV
ALKPA---
---
PEGATTHWYHAPQ
P
VVTPEEEE
L
RK
L
AQL
L
RY
S
SN
I
A
L
MC
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
IVHA
L
R
G
KE
HV
E
YD
N
P
YDV
GM
T
G
L
I
G
FSSGFHT
M
M
NAD
T
L
VL
L
G
T
Q
F
PY
R
A------
F
Y
P
T
D
A
KI
I
Q
IDI
N
P
A
S
I
GAHSKVD
M
A
L
VGD
IKST
L
RA
LL
PL
V
EEKADRK
F
L
D
--
--
-
-
K
ALEDY
R
DARKGLDDLAKPS
E
----------------------------
K
A
IHPQYLAQQ
I
SH
----
FAADDAIF
T
C
DVG
TP
T
V
W
AA
RY
-
LKMNG
K
R
RL
L
G
S
F
--------
NH
G
S
M
A
N
AM
P
Q
A
L
GA
QA
T
E
P
ERQ
VV
A
MC
GDG
GFS
M
LMG
D
FL
S
VV
Q
MK
LPV
K
I
I
VF
NN
SV
LG
F
V
A
-
--ME
M
KAGGYLTDGTELHD
-----------
TN
F
AR
I
A
E
A
C
G
IT
G
IR
V
EKAS
E
IDE
AL
QRAFSI
---
DG
P
VL
V
D
V
V
VA
KE
--------
E
LAI
P
P
Q
IK
fig|656419.3.peg.1165
Escherichia coli M718 (9-539/572)
I
A
KT
L
ESA
GV
KR
I
W
G
VT
G
DS
L
NG
L
S
D
S
L
NRM
-
G
T
I
E
W
M
ST
RHE
E
V
A
AFA
A
G
A
E
A
QLS
G
E
L
A
V
--
C
AGS
C
GPG
N
LH
L
I
N
GL
F
D
C
HR
N
HV
P
VL
A
I
A
A
HIPSSE
IG
--
S
G
Y
FQE
T
H
PQ
--------
ELFRECS
H
YCE
LV
SSP
E
Q
I
P
QV
L
AI
A
MRK
A
V
L
-
N
R
-
G
V
S
V
V
V
LP
G
DV
ALKPA---
---
PEGATTHWYHAPQ
P
VVTPEEEE
L
RK
L
AQL
L
RY
S
SN
I
A
L
MC
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
IVHA
L
R
G
KE
HV
E
YD
N
P
YDV
GM
T
G
L
I
G
FSSGFHT
M
M
NAD
T
L
VL
L
G
T
Q
F
PY
R
A------
F
Y
P
T
D
A
KI
I
Q
IDI
N
P
A
S
I
GAHSKVD
M
A
L
VGD
IKST
L
RA
LL
PL
V
EEKADRK
F
L
D
--
--
-
-
K
ALEDY
R
DARKGLDDLAKPS
E
----------------------------
K
A
IHPQYLAQQ
I
SH
----
FAADDAIF
T
C
DVG
TP
T
V
W
AA
RY
-
LKMNG
K
R
RL
L
G
S
F
--------
NH
G
S
M
A
N
AM
P
Q
A
L
GA
QA
T
E
P
ERQ
VV
A
MC
GDG
GFS
M
LMG
D
FL
S
VV
Q
MK
LPV
K
I
I
VF
NN
SV
LG
F
V
A
-
--ME
M
KAGGYLTDGTELHD
-----------
TN
F
AR
I
A
E
A
C
G
IT
G
IR
V
EKAS
E
IDE
AL
QRAFSI
---
DG
P
VL
V
D
V
V
VA
KE
--------
E
LAI
P
P
Q
IK
fig|83334.1.peg.1025
Escherichia coli O157:H7 (9-539/572)
I
A
KT
L
ESA
GV
KR
I
W
G
VT
G
DS
L
NG
L
S
D
S
L
NRM
-
G
T
I
E
W
M
ST
RHE
E
V
A
AFA
A
G
A
E
A
QLS
G
E
L
A
V
--
C
AGS
C
GPG
N
LH
L
I
N
GL
F
D
C
HR
N
HV
P
VL
A
I
A
A
HIPSSE
IG
--
S
G
Y
FQE
T
H
PQ
--------
ELFRECS
H
YCE
LV
SSP
E
Q
I
P
QV
L
AI
A
MRK
A
V
L
-
N
R
-
G
V
S
V
V
V
LP
G
DV
ALKPA---
---
PEGATTHWYHAPQ
P
VVTPEEEE
L
RK
L
AQL
L
RY
S
SN
I
A
L
MC
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
IVHA
L
R
G
KE
HV
E
YD
N
P
YDV
GM
T
G
L
I
G
FSSGFHT
M
M
NAD
T
L
VL
L
G
T
Q
F
PY
R
A------
F
Y
P
T
D
A
KI
I
Q
IDI
N
P
A
S
I
GAHSKVD
M
A
L
VGD
IKST
L
RA
LL
PL
V
EEKADRK
F
L
D
--
--
-
-
K
ALEDY
R
DARKGLDDLAKPS
E
----------------------------
K
A
IHPQYLAQQ
I
SH
----
FAADDAIF
T
C
DVG
TP
T
V
W
AA
RY
-
LKMNG
K
R
RL
L
G
S
F
--------
NH
G
S
M
A
N
AM
P
Q
A
L
GA
QA
T
E
P
ERQ
VV
A
MC
GDG
GFS
M
LMG
D
FL
S
VV
Q
MK
LPV
K
I
I
VF
NN
SV
LG
F
V
A
-
--ME
M
KAGGYLTDGTELHD
-----------
TN
F
AR
I
A
E
A
C
G
IT
G
IR
V
EKAS
E
IDE
AL
QRAFSI
---
DG
P
VL
V
D
V
V
VA
KE
--------
E
LAI
P
P
Q
IK
fig|155864.1.peg.951
Escherichia coli O157:H7 EDL933 (9-539/572)
I
A
KT
L
ESA
GV
KR
I
W
G
VT
G
DS
L
NG
L
S
D
S
L
NRM
-
G
T
I
E
W
M
ST
RHE
E
V
A
AFA
A
G
A
E
A
QLS
G
E
L
A
V
--
C
AGS
C
GPG
N
LH
L
I
N
GL
F
D
C
HR
N
HV
P
VL
A
I
A
A
HIPSSE
IG
--
S
G
Y
FQE
T
H
PQ
--------
ELFRECS
H
YCE
LV
SSP
E
Q
I
P
QV
L
AI
A
MRK
A
V
L
-
N
R
-
G
V
S
V
V
V
LP
G
DV
ALKPA---
---
PEGATTHWYHAPQ
P
VVTPEEEE
L
RK
L
AQL
L
RY
S
SN
I
A
L
MC
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
IVHA
L
R
G
KE
HV
E
YD
N
P
YDV
GM
T
G
L
I
G
FSSGFHT
M
M
NAD
T
L
VL
L
G
T
Q
F
PY
R
A------
F
Y
P
T
D
A
KI
I
Q
IDI
N
P
A
S
I
GAHSKVD
M
A
L
VGD
IKST
L
RA
LL
PL
V
EEKADRK
F
L
D
--
--
-
-
K
ALEDY
R
DARKGLDDLAKPS
E
----------------------------
K
A
IHPQYLAQQ
I
SH
----
FAADDAIF
T
C
DVG
TP
T
V
W
AA
RY
-
LKMNG
K
R
RL
L
G
S
F
--------
NH
G
S
M
A
N
AM
P
Q
A
L
GA
QA
T
E
P
ERQ
VV
A
MC
GDG
GFS
M
LMG
D
FL
S
VV
Q
MK
LPV
K
I
I
VF
NN
SV
LG
F
V
A
-
--ME
M
KAGGYLTDGTELHD
-----------
TN
F
AR
I
A
E
A
C
G
IT
G
IR
V
EKAS
E
IDE
AL
QRAFSI
---
DG
P
VL
V
D
V
V
VA
KE
--------
E
LAI
P
P
Q
IK
fig|444454.5.peg.5451
Escherichia coli O157:H7 str. EC4024 (9-539/572)
I
A
KT
L
ESA
GV
KR
I
W
G
VT
G
DS
L
NG
L
S
D
S
L
NRM
-
G
T
I
E
W
M
ST
RHE
E
V
A
AFA
A
G
A
E
A
QLS
G
E
L
A
V
--
C
AGS
C
GPG
N
LH
L
I
N
GL
F
D
C
HR
N
HV
P
VL
A
I
A
A
HIPSSE
IG
--
S
G
Y
FQE
T
H
PQ
--------
ELFRECS
H
YCE
LV
SSP
E
Q
I
P
QV
L
AI
A
MRK
A
V
L
-
N
R
-
G
V
S
V
V
V
LP
G
DV
ALKPA---
---
PEGATTHWYHAPQ
P
VVTPEEEE
L
RK
L
AQL
L
RY
S
SN
I
A
L
MC
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
IVHA
L
R
G
KE
HV
E
YD
N
P
YDV
GM
T
G
L
I
G
FSSGFHT
M
M
NAD
T
L
VL
L
G
T
Q
F
PY
R
A------
F
Y
P
T
D
A
KI
I
Q
IDI
N
P
A
S
I
GAHSKVD
M
A
L
VGD
IKST
L
RA
LL
PL
V
EEKADRK
F
L
D
--
--
-
-
K
ALEDY
R
DARKGLDDLAKPS
E
----------------------------
K
A
IHPQYLAQQ
I
SH
----
FAADDAIF
T
C
DVG
TP
T
V
W
AA
RY
-
LKMNG
K
R
RL
L
G
S
F
--------
NH
G
S
M
A
N
AM
P
Q
A
L
GA
QA
T
E
P
ERQ
VV
A
MC
GDG
GFS
M
LMG
D
FL
S
VV
Q
MK
LPV
K
I
I
VF
NN
SV
LG
F
V
A
-
--ME
M
KAGGYLTDGTELHD
-----------
TN
F
AR
I
A
E
A
C
G
IT
G
IR
V
EKAS
E
IDE
AL
QRAFSI
---
DG
P
VL
V
D
V
V
VA
KE
--------
E
LAI
P
P
Q
IK
fig|444449.5.peg.4384
Escherichia coli O157:H7 str. EC4042 (9-539/572)
I
A
KT
L
ESA
GV
KR
I
W
G
VT
G
DS
L
NG
L
S
D
S
L
NRM
-
G
T
I
E
W
M
ST
RHE
E
V
A
AFA
A
G
A
E
A
QLS
G
E
L
A
V
--
C
AGS
C
GPG
N
LH
L
I
N
GL
F
D
C
HR
N
HV
P
VL
A
I
A
A
HIPSSE
IG
--
S
G
Y
FQE
T
H
PQ
--------
ELFRECS
H
YCE
LV
SSP
E
Q
I
P
QV
L
AI
A
MRK
A
V
L
-
N
R
-
G
V
S
V
V
V
LP
G
DV
ALKPA---
---
PEGATTHWYHAPQ
P
VVTPEEEE
L
RK
L
AQL
L
RY
S
SN
I
A
L
MC
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
IVHA
L
R
G
KE
HV
E
YD
N
P
YDV
GM
T
G
L
I
G
FSSGFHT
M
M
NAD
T
L
VL
L
G
T
Q
F
PY
R
A------
F
Y
P
T
D
A
KI
I
Q
IDI
N
P
A
S
I
GAHSKVD
M
A
L
VGD
IKST
L
RA
LL
PL
V
EEKADRK
F
L
D
--
--
-
-
K
ALEDY
R
DARKGLDDLAKPS
E
----------------------------
K
A
IHPQYLAQQ
I
SH
----
FAADDAIF
T
C
DVG
TP
T
V
W
AA
RY
-
LKMNG
K
R
RL
L
G
S
F
--------
NH
G
S
M
A
N
AM
P
Q
A
L
GA
QA
T
E
P
ERQ
VV
A
MC
GDG
GFS
M
LMG
D
FL
S
VV
Q
MK
LPV
K
I
I
VF
NN
SV
LG
F
V
A
-
--ME
M
KAGGYLTDGTELHD
-----------
TN
F
AR
I
A
E
A
C
G
IT
G
IR
V
EKAS
E
IDE
AL
QRAFSI
---
DG
P
VL
V
D
V
V
VA
KE
--------
E
LAI
P
P
Q
IK
fig|444448.5.peg.3661
Escherichia coli O157:H7 str. EC4045 (9-539/572)
I
A
KT
L
ESA
GV
KR
I
W
G
VT
G
DS
L
NG
L
S
D
S
L
NRM
-
G
T
I
E
W
M
ST
RHE
E
V
A
AFA
A
G
A
E
A
QLS
G
E
L
A
V
--
C
AGS
C
GPG
N
LH
L
I
N
GL
F
D
C
HR
N
HV
P
VL
A
I
A
A
HIPSSE
IG
--
S
G
Y
FQE
T
H
PQ
--------
ELFRECS
H
YCE
LV
SSP
E
Q
I
P
QV
L
AI
A
MRK
A
V
L
-
N
R
-
G
V
S
V
V
V
LP
G
DV
ALKPA---
---
PEGATTHWYHAPQ
P
VVTPEEEE
L
RK
L
AQL
L
RY
S
SN
I
A
L
MC
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
IVHA
L
R
G
KE
HV
E
YD
N
P
YDV
GM
T
G
L
I
G
FSSGFHT
M
M
NAD
T
L
VL
L
G
T
Q
F
PY
R
A------
F
Y
P
T
D
A
KI
I
Q
IDI
N
P
A
S
I
GAHSKVD
M
A
L
VGD
IKST
L
RA
LL
PL
V
EEKADRK
F
L
D
--
--
-
-
K
ALEDY
R
DARKGLDDLAKPS
E
----------------------------
K
A
IHPQYLAQQ
I
SH
----
FAADDAIF
T
C
DVG
TP
T
V
W
AA
RY
-
LKMNG
K
R
RL
L
G
S
F
--------
NH
G
S
M
A
N
AM
P
Q
A
L
GA
QA
T
E
P
ERQ
VV
A
MC
GDG
GFS
M
LMG
D
FL
S
VV
Q
MK
LPV
K
I
I
VF
NN
SV
LG
F
V
A
-
--ME
M
KAGGYLTDGTELHD
-----------
TN
F
AR
I
A
E
A
C
G
IT
G
IR
V
EKAS
E
IDE
AL
QRAFSI
---
DG
P
VL
V
D
V
V
VA
KE
--------
E
LAI
P
P
Q
IK
fig|444453.5.peg.1001
Escherichia coli O157:H7 str. EC4076 (9-539/572)
I
A
KT
L
ESA
GV
KR
I
W
G
VT
G
DS
L
NG
L
S
D
S
L
NRM
-
G
T
I
E
W
M
ST
RHE
E
V
A
AFA
A
G
A
E
A
QLS
G
E
L
A
V
--
C
AGS
C
GPG
N
LH
L
I
N
GL
F
D
C
HR
N
HV
P
VL
A
I
A
A
HIPSSE
IG
--
S
G
Y
FQE
T
H
PQ
--------
ELFRECS
H
YCE
LV
SSP
E
Q
I
P
QV
L
AI
A
MRK
A
V
L
-
N
R
-
G
V
S
V
V
V
LP
G
DV
ALKPA---
---
PEGATTHWYHAPQ
P
VVTPEEEE
L
RK
L
AQL
L
RY
S
SN
I
A
L
MC
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
IVHA
L
R
G
KE
HV
E
YD
N
P
YDV
GM
T
G
L
I
G
FSSGFHT
M
M
NAD
T
L
VL
L
G
T
Q
F
PY
R
A------
F
Y
P
T
D
A
KI
I
Q
IDI
N
P
A
S
I
GAHSKVD
M
A
L
VGD
IKST
L
RA
LL
PL
V
EEKADRK
F
L
D
--
--
-
-
K
ALEDY
R
DARKGLDDLAKPS
E
----------------------------
K
A
IHPQYLAQQ
I
SH
----
FAADDAIF
T
C
DVG
TP
T
V
W
AA
RY
-
LKMNG
K
R
RL
L
G
S
F
--------
NH
G
S
M
A
N
AM
P
Q
A
L
GA
QA
T
E
P
ERQ
VV
A
MC
GDG
GFS
M
LMG
D
FL
S
VV
Q
MK
LPV
K
I
I
VF
NN
SV
LG
F
V
A
-
--ME
M
KAGGYLTDGTELHD
-----------
TN
F
AR
I
A
E
A
C
G
IT
G
IR
V
EKAS
E
IDE
AL
QRAFSI
---
DG
P
VL
V
D
V
V
VA
KE
--------
E
LAI
P
P
Q
IK
fig|444452.5.peg.3046
Escherichia coli O157:H7 str. EC4113 (9-539/572)
I
A
KT
L
ESA
GV
KR
I
W
G
VT
G
DS
L
NG
L
S
D
S
L
NRM
-
G
T
I
E
W
M
ST
RHE
E
V
A
AFA
A
G
A
E
A
QLS
G
E
L
A
V
--
C
AGS
C
GPG
N
LH
L
I
N
GL
F
D
C
HR
N
HV
P
VL
A
I
A
A
HIPSSE
IG
--
S
G
Y
FQE
T
H
PQ
--------
ELFRECS
H
YCE
LV
SSP
E
Q
I
P
QV
L
AI
A
MRK
A
V
L
-
N
R
-
G
V
S
V
V
V
LP
G
DV
ALKPA---
---
PEGATTHWYHAPQ
P
VVTPEEEE
L
RK
L
AQL
L
RY
S
SN
I
A
L
MC
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
IVHA
L
R
G
KE
HV
E
YD
N
P
YDV
GM
T
G
L
I
G
FSSGFHT
M
M
NAD
T
L
VL
L
G
T
Q
F
PY
R
A------
F
Y
P
T
D
A
KI
I
Q
IDI
N
P
A
S
I
GAHSKVD
M
A
L
VGD
IKST
L
RA
LL
PL
V
EEKADRK
F
L
D
--
--
-
-
K
ALEDY
R
DARKGLDDLAKPS
E
----------------------------
K
A
IHPQYLAQQ
I
SH
----
FAADDAIF
T
C
DVG
TP
T
V
W
AA
RY
-
LKMNG
K
R
RL
L
G
S
F
--------
NH
G
S
M
A
N
AM
P
Q
A
L
GA
QA
T
E
P
ERQ
VV
A
MC
GDG
GFS
M
LMG
D
FL
S
VV
Q
MK
LPV
K
I
I
VF
NN
SV
LG
F
V
A
-
--ME
M
KAGGYLTDGTELHD
-----------
TN
F
AR
I
A
E
A
C
G
IT
G
IR
V
EKAS
E
IDE
AL
QRAFSI
---
DG
P
VL
V
D
V
V
VA
KE
--------
E
LAI
P
P
Q
IK
fig|444450.8.peg.1118
Escherichia coli O157:H7 str. EC4115 (9-539/572)
I
A
KT
L
ESA
GV
KR
I
W
G
VT
G
DS
L
NG
L
S
D
S
L
NRM
-
G
T
I
E
W
M
ST
RHE
E
V
A
AFA
A
G
A
E
A
QLS
G
E
L
A
V
--
C
AGS
C
GPG
N
LH
L
I
N
GL
F
D
C
HR
N
HV
P
VL
A
I
A
A
HIPSSE
IG
--
S
G
Y
FQE
T
H
PQ
--------
ELFRECS
H
YCE
LV
SSP
E
Q
I
P
QV
L
AI
A
MRK
A
V
L
-
N
R
-
G
V
S
V
V
V
LP
G
DV
ALKPA---
---
PEGATTHWYHAPQ
P
VVTPEEEE
L
RK
L
AQL
L
RY
S
SN
I
A
L
MC
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
IVHA
L
R
G
KE
HV
E
YD
N
P
YDV
GM
T
G
L
I
G
FSSGFHT
M
M
NAD
T
L
VL
L
G
T
Q
F
PY
R
A------
F
Y
P
T
D
A
KI
I
Q
IDI
N
P
A
S
I
GAHSKVD
M
A
L
VGD
IKST
L
RA
LL
PL
V
EEKADRK
F
L
D
--
--
-
-
K
ALEDY
R
DARKGLDDLAKPS
E
----------------------------
K
A
IHPQYLAQQ
I
SH
----
FAADDAIF
T
C
DVG
TP
T
V
W
AA
RY
-
LKMNG
K
R
RL
L
G
S
F
--------
NH
G
S
M
A
N
AM
P
Q
A
L
GA
QA
T
E
P
ERQ
VV
A
MC
GDG
GFS
M
LMG
D
FL
S
VV
Q
MK
LPV
K
I
I
VF
NN
SV
LG
F
V
A
-
--ME
M
KAGGYLTDGTELHD
-----------
TN
F
AR
I
A
E
A
C
G
IT
G
IR
V
EKAS
E
IDE
AL
QRAFSI
---
DG
P
VL
V
D
V
V
VA
KE
--------
E
LAI
P
P
Q
IK
fig|444451.5.peg.3931
Escherichia coli O157:H7 str. EC4196 (9-539/572)
I
A
KT
L
ESA
GV
KR
I
W
G
VT
G
DS
L
NG
L
S
D
S
L
NRM
-
G
T
I
E
W
M
ST
RHE
E
V
A
AFA
A
G
A
E
A
QLS
G
E
L
A
V
--
C
AGS
C
GPG
N
LH
L
I
N
GL
F
D
C
HR
N
HV
P
VL
A
I
A
A
HIPSSE
IG
--
S
G
Y
FQE
T
H
PQ
--------
ELFRECS
H
YCE
LV
SSP
E
Q
I
P
QV
L
AI
A
MRK
A
V
L
-
N
R
-
G
V
S
V
V
V
LP
G
DV
ALKPA---
---
PEGATTHWYHAPQ
P
VVTPEEEE
L
RK
L
AQL
L
RY
S
SN
I
A
L
MC
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
IVHA
L
R
G
KE
HV
E
YD
N
P
YDV
GM
T
G
L
I
G
FSSGFHT
M
M
NAD
T
L
VL
L
G
T
Q
F
PY
R
A------
F
Y
P
T
D
A
KI
I
Q
IDI
N
P
A
S
I
GAHSKVD
M
A
L
VGD
IKST
L
RA
LL
PL
V
EEKADRK
F
L
D
--
--
-
-
K
ALEDY
R
DARKGLDDLAKPS
E
----------------------------
K
A
IHPQYLAQQ
I
SH
----
FAADDAIF
T
C
DVG
TP
T
V
W
AA
RY
-
LKMNG
K
R
RL
L
G
S
F
--------
NH
G
S
M
A
N
AM
P
Q
A
L
GA
QA
T
E
P
ERQ
VV
A
MC
GDG
GFS
M
LMG
D
FL
S
VV
Q
MK
LPV
K
I
I
VF
NN
SV
LG
F
V
A
-
--ME
M
KAGGYLTDGTELHD
-----------
TN
F
AR
I
A
E
A
C
G
IT
G
IR
V
EKAS
E
IDE
AL
QRAFSI
---
DG
P
VL
V
D
V
V
VA
KE
--------
E
LAI
P
P
Q
IK
fig|444447.5.peg.3857
Escherichia coli O157:H7 str. EC4206 (9-539/572)
I
A
KT
L
ESA
GV
KR
I
W
G
VT
G
DS
L
NG
L
S
D
S
L
NRM
-
G
T
I
E
W
M
ST
RHE
E
V
A
AFA
A
G
A
E
A
QLS
G
E
L
A
V
--
C
AGS
C
GPG
N
LH
L
I
N
GL
F
D
C
HR
N
HV
P
VL
A
I
A
A
HIPSSE
IG
--
S
G
Y
FQE
T
H
PQ
--------
ELFRECS
H
YCE
LV
SSP
E
Q
I
P
QV
L
AI
A
MRK
A
V
L
-
N
R
-
G
V
S
V
V
V
LP
G
DV
ALKPA---
---
PEGATTHWYHAPQ
P
VVTPEEEE
L
RK
L
AQL
L
RY
S
SN
I
A
L
MC
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
IVHA
L
R
G
KE
HV
E
YD
N
P
YDV
GM
T
G
L
I
G
FSSGFHT
M
M
NAD
T
L
VL
L
G
T
Q
F
PY
R
A------
F
Y
P
T
D
A
KI
I
Q
IDI
N
P
A
S
I
GAHSKVD
M
A
L
VGD
IKST
L
RA
LL
PL
V
EEKADRK
F
L
D
--
--
-
-
K
ALEDY
R
DARKGLDDLAKPS
E
----------------------------
K
A
IHPQYLAQQ
I
SH
----
FAADDAIF
T
C
DVG
TP
T
V
W
AA
RY
-
LKMNG
K
R
RL
L
G
S
F
--------
NH
G
S
M
A
N
AM
P
Q
A
L
GA
QA
T
E
P
ERQ
VV
A
MC
GDG
GFS
M
LMG
D
FL
S
VV
Q
MK
LPV
K
I
I
VF
NN
SV
LG
F
V
A
-
--ME
M
KAGGYLTDGTELHD
-----------
TN
F
AR
I
A
E
A
C
G
IT
G
IR
V
EKAS
E
IDE
AL
QRAFSI
---
DG
P
VL
V
D
V
V
VA
KE
--------
E
LAI
P
P
Q
IK
fig|478004.5.peg.3378
Escherichia coli O157:H7 str. EC4401 (9-539/572)
I
A
KT
L
ESA
GV
KR
I
W
G
VT
G
DS
L
NG
L
S
D
S
L
NRM
-
G
T
I
E
W
M
ST
RHE
E
V
A
AFA
A
G
A
E
A
QLS
G
E
L
A
V
--
C
AGS
C
GPG
N
LH
L
I
N
GL
F
D
C
HR
N
HV
P
VL
A
I
A
A
HIPSSE
IG
--
S
G
Y
FQE
T
H
PQ
--------
ELFRECS
H
YCE
LV
SSP
E
Q
I
P
QV
L
AI
A
MRK
A
V
L
-
N
R
-
G
V
S
V
V
V
LP
G
DV
ALKPA---
---
PEGATTHWYHAPQ
P
VVTPEEEE
L
RK
L
AQL
L
RY
S
SN
I
A
L
MC
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
IVHA
L
R
G
KE
HV
E
YD
N
P
YDV
GM
T
G
L
I
G
FSSGFHT
M
M
NAD
T
L
VL
L
G
T
Q
F
PY
R
A------
F
Y
P
T
D
A
KI
I
Q
IDI
N
P
A
S
I
GAHSKVD
M
A
L
VGD
IKST
L
RA
LL
PL
V
EEKADRK
F
L
D
--
--
-
-
K
ALEDY
R
DARKGLDDLAKPS
E
----------------------------
K
A
IHPQYLAQQ
I
SH
----
FAADDAIF
T
C
DVG
TP
T
V
W
AA
RY
-
LKMNG
K
R
RL
L
G
S
F
--------
NH
G
S
M
A
N
AM
P
Q
A
L
GA
QA
T
E
P
ERQ
VV
A
MC
GDG
GFS
M
LMG
D
FL
S
VV
Q
MK
LPV
K
I
I
VF
NN
SV
LG
F
V
A
-
--ME
M
KAGGYLTDGTELHD
-----------
TN
F
AR
I
A
E
A
C
G
IT
G
IR
V
EKAS
E
IDE
AL
QRAFSI
---
DG
P
VL
V
D
V
V
VA
KE
--------
E
LAI
P
P
Q
IK
fig|478005.5.peg.1500
Escherichia coli O157:H7 str. EC4486 (9-539/572)
I
A
KT
L
ESA
GV
KR
I
W
G
VT
G
DS
L
NG
L
S
D
S
L
NRM
-
G
T
I
E
W
M
ST
RHE
E
V
A
AFA
A
G
A
E
A
QLS
G
E
L
A
V
--
C
AGS
C
GPG
N
LH
L
I
N
GL
F
D
C
HR
N
HV
P
VL
A
I
A
A
HIPSSE
IG
--
S
G
Y
FQE
T
H
PQ
--------
ELFRECS
H
YCE
LV
SSP
E
Q
I
P
QV
L
AI
A
MRK
A
V
L
-
N
R
-
G
V
S
V
V
V
LP
G
DV
ALKPA---
---
PEGATTHWYHAPQ
P
VVTPEEEE
L
RK
L
AQL
L
RY
S
SN
I
A
L
MC
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
IVHA
L
R
G
KE
HV
E
YD
N
P
YDV
GM
T
G
L
I
G
FSSGFHT
M
M
NAD
T
L
VL
L
G
T
Q
F
PY
R
A------
F
Y
P
T
D
A
KI
I
Q
IDI
N
P
A
S
I
GAHSKVD
M
A
L
VGD
IKST
L
RA
LL
PL
V
EEKADRK
F
L
D
--
--
-
-
K
ALEDY
R
DARKGLDDLAKPS
E
----------------------------
K
A
IHPQYLAQQ
I
SH
----
FAADDAIF
T
C
DVG
TP
T
V
W
AA
RY
-
LKMNG
K
R
RL
L
G
S
F
--------
NH
G
S
M
A
N
AM
P
Q
A
L
GA
QA
T
E
P
ERQ
VV
A
MC
GDG
GFS
M
LMG
D
FL
S
VV
Q
MK
LPV
K
I
I
VF
NN
SV
LG
F
V
A
-
--ME
M
KAGGYLTDGTELHD
-----------
TN
F
AR
I
A
E
A
C
G
IT
G
IR
V
EKAS
E
IDE
AL
QRAFSI
---
DG
P
VL
V
D
V
V
VA
KE
--------
E
LAI
P
P
Q
IK
fig|478006.5.peg.3673
Escherichia coli O157:H7 str. EC4501 (9-539/572)
I
A
KT
L
ESA
GV
KR
I
W
G
VT
G
DS
L
NG
L
S
D
S
L
NRM
-
G
T
I
E
W
M
ST
RHE
E
V
A
AFA
A
G
A
E
A
QLS
G
E
L
A
V
--
C
AGS
C
GPG
N
LH
L
I
N
GL
F
D
C
HR
N
HV
P
VL
A
I
A
A
HIPSSE
IG
--
S
G
Y
FQE
T
H
PQ
--------
ELFRECS
H
YCE
LV
SSP
E
Q
I
P
QV
L
AI
A
MRK
A
V
L
-
N
R
-
G
V
S
V
V
V
LP
G
DV
ALKPA---
---
PEGATTHWYHAPQ
P
VVTPEEEE
L
RK
L
AQL
L
RY
S
SN
I
A
L
MC
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
IVHA
L
R
G
KE
HV
E
YD
N
P
YDV
GM
T
G
L
I
G
FSSGFHT
M
M
NAD
T
L
VL
L
G
T
Q
F
PY
R
A------
F
Y
P
T
D
A
KI
I
Q
IDI
N
P
A
S
I
GAHSKVD
M
A
L
VGD
IKST
L
RA
LL
PL
V
EEKADRK
F
L
D
--
--
-
-
K
ALEDY
R
DARKGLDDLAKPS
E
----------------------------
K
A
IHPQYLAQQ
I
SH
----
FAADDAIF
T
C
DVG
TP
T
V
W
AA
RY
-
LKMNG
K
R
RL
L
G
S
F
--------
NH
G
S
M
A
N
AM
P
Q
A
L
GA
QA
T
E
P
ERQ
VV
A
MC
GDG
GFS
M
LMG
D
FL
S
VV
Q
MK
LPV
K
I
I
VF
NN
SV
LG
F
V
A
-
--ME
M
KAGGYLTDGTELHD
-----------
TN
F
AR
I
A
E
A
C
G
IT
G
IR
V
EKAS
E
IDE
AL
QRAFSI
---
DG
P
VL
V
D
V
V
VA
KE
--------
E
LAI
P
P
Q
IK
fig|478007.5.peg.2553
Escherichia coli O157:H7 str. EC508 (9-539/572)
I
A
KT
L
ESA
GV
KR
I
W
G
VT
G
DS
L
NG
L
S
D
S
L
NRM
-
G
T
I
E
W
M
ST
RHE
E
V
A
AFA
A
G
A
E
A
QLS
G
E
L
A
V
--
C
AGS
C
GPG
N
LH
L
I
N
GL
F
D
C
HR
N
HV
P
VL
A
I
A
A
HIPSSE
IG
--
S
G
Y
FQE
T
H
PQ
--------
ELFRECS
H
YCE
LV
SSP
E
Q
I
P
QV
L
AI
A
MRK
A
V
L
-
N
R
-
G
V
S
V
V
V
LP
G
DV
ALKPA---
---
PEGATTHWYHAPQ
P
VVTPEEEE
L
RK
L
AQL
L
RY
S
SN
I
A
L
MC
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
IVHA
L
R
G
KE
HV
E
YD
N
P
YDV
GM
T
G
L
I
G
FSSGFHT
M
M
NAD
T
L
VL
L
G
T
Q
F
PY
R
A------
F
Y
P
T
D
A
KI
I
Q
IDI
N
P
A
S
I
GAHSKVD
M
A
L
VGD
IKST
L
RA
LL
PL
V
EEKADRK
F
L
D
--
--
-
-
K
ALEDY
R
DARKGLDDLAKPS
E
----------------------------
K
A
IHPQYLAQQ
I
SH
----
FAADDAIF
T
C
DVG
TP
T
V
W
AA
RY
-
LKMNG
K
R
RL
L
G
S
F
--------
NH
G
S
M
A
N
AM
P
Q
A
L
GA
QA
T
E
P
ERQ
VV
A
MC
GDG
GFS
M
LMG
D
FL
S
VV
Q
MK
LPV
K
I
I
VF
NN
SV
LG
F
V
A
-
--ME
M
KAGGYLTDGTELHD
-----------
TN
F
AR
I
A
E
A
C
G
IT
G
IR
V
EKAS
E
IDE
AL
QRAFSI
---
DG
P
VL
V
D
V
V
VA
KE
--------
E
LAI
P
P
Q
IK
fig|478008.5.peg.2352
Escherichia coli O157:H7 str. EC869 (9-539/572)
I
A
KT
L
ESA
GV
KR
I
W
G
VT
G
DS
L
NG
L
S
D
S
L
NRM
-
G
T
I
E
W
M
ST
RHE
E
V
A
AFA
A
G
A
E
A
QLS
G
E
L
A
V
--
C
AGS
C
GPG
N
LH
L
I
N
GL
F
D
C
HR
N
HV
P
VL
A
I
A
A
HIPSSE
IG
--
S
G
Y
FQE
T
H
PQ
--------
ELFRECS
H
YCE
LV
SSP
E
Q
I
P
QV
L
AI
A
MRK
A
V
L
-
N
R
-
G
V
S
V
V
V
LP
G
DV
ALKPA---
---
PEGATTHWYHAPQ
P
VVTPEEEE
L
RK
L
AQL
L
RY
S
SN
I
A
L
MC
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
IVHA
L
R
G
KE
HV
E
YD
N
P
YDV
GM
T
G
L
I
G
FSSGFHT
M
M
NAD
T
L
VL
L
G
T
Q
F
PY
R
A------
F
Y
P
T
D
A
KI
I
Q
IDI
N
P
A
S
I
GAHSKVD
M
A
L
VGD
IKST
L
RA
LL
PL
V
EEKADRK
F
L
D
--
--
-
-
K
ALEDY
R
DARKGLDDLAKPS
E
----------------------------
K
A
IHPQYLAQQ
I
SH
----
FAADDAIF
T
C
DVG
TP
T
V
W
AA
RY
-
LKMNG
K
R
RL
L
G
S
F
--------
NH
G
S
M
A
N
AM
P
Q
A
L
GA
QA
T
E
P
ERQ
VV
A
MC
GDG
GFS
M
LMG
D
FL
S
VV
Q
MK
LPV
K
I
I
VF
NN
SV
LG
F
V
A
-
--ME
M
KAGGYLTDGTELHD
-----------
TN
F
AR
I
A
E
A
C
G
IT
G
IR
V
EKAS
E
IDE
AL
QRAFSI
---
DG
P
VL
V
D
V
V
VA
KE
--------
E
LAI
P
P
Q
IK
fig|637388.3.peg.2650
Escherichia coli O157:H7 str. FRIK2000 (9-539/572)
I
A
KT
L
ESA
GV
KR
I
W
G
VT
G
DS
L
NG
L
S
D
S
L
NRM
-
G
T
I
E
W
M
ST
RHE
E
V
A
AFA
A
G
A
E
A
QLS
G
E
L
A
V
--
C
AGS
C
GPG
N
LH
L
I
N
GL
F
D
C
HR
N
HV
P
VL
A
I
A
A
HIPSSE
IG
--
S
G
Y
FQE
T
H
PQ
--------
ELFRECS
H
YCE
LV
SSP
E
Q
I
P
QV
L
AI
A
MRK
A
V
L
-
N
R
-
G
V
S
V
V
V
LP
G
DV
ALKPA---
---
PEGATTHWYHAPQ
P
VVTPEEEE
L
RK
L
AQL
L
RY
S
SN
I
A
L
MC
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
IVHA
L
R
G
KE
HV
E
YD
N
P
YDV
GM
T
G
L
I
G
FSSGFHT
M
M
NAD
T
L
VL
L
G
T
Q
F
PY
R
A------
F
Y
P
T
D
A
KI
I
Q
IDI
N
P
A
S
I
GAHSKVD
M
A
L
VGD
IKST
L
RA
LL
PL
V
EEKADRK
F
L
D
--
--
-
-
K
ALEDY
R
DARKGLDDLAKPS
E
----------------------------
K
A
IHPQYLAQQ
I
SH
----
FAADDAIF
T
C
DVG
TP
T
V
W
AA
RY
-
LKMNG
K
R
RL
L
G
S
F
--------
NH
G
S
M
A
N
AM
P
Q
A
L
GA
QA
T
E
P
ERQ
VV
A
MC
GDG
GFS
M
LMG
D
FL
S
VV
Q
MK
LPV
K
I
I
VF
NN
SV
LG
F
V
A
-
--ME
M
KAGGYLTDGTELHD
-----------
TN
F
AR
I
A
E
A
C
G
IT
G
IR
V
EKAS
E
IDE
AL
QRAFSI
---
DG
P
VL
V
D
V
V
VA
KE
--------
E
LAI
P
P
Q
IK
fig|570506.3.peg.4379
Escherichia coli O157:H7 str. FRIK966 (9-539/572)
I
A
KT
L
ESA
GV
KR
I
W
G
VT
G
DS
L
NG
L
S
D
S
L
NRM
-
G
T
I
E
W
M
ST
RHE
E
V
A
AFA
A
G
A
E
A
QLS
G
E
L
A
V
--
C
AGS
C
GPG
N
LH
L
I
N
GL
F
D
C
HR
N
HV
P
VL
A
I
A
A
HIPSSE
IG
--
S
G
Y
FQE
T
H
PQ
--------
ELFRECS
H
YCE
LV
SSP
E
Q
I
P
QV
L
AI
A
MRK
A
V
L
-
N
R
-
G
V
S
V
V
V
LP
G
DV
ALKPA---
---
PEGATTHWYHAPQ
P
VVTPEEEE
L
RK
L
AQL
L
RY
S
SN
I
A
L
MC
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
IVHA
L
R
G
KE
HV
E
YD
N
P
YDV
GM
T
G
L
I
G
FSSGFHT
M
M
NAD
T
L
VL
L
G
T
Q
F
PY
R
A------
F
Y
P
T
D
A
KI
I
Q
IDI
N
P
A
S
I
GAHSKVD
M
A
L
VGD
IKST
L
RA
LL
PL
V
EEKADRK
F
L
D
--
--
-
-
K
ALEDY
R
DARKGLDDLAKPS
E
----------------------------
K
A
IHPQYLAQQ
I
SH
----
FAADDAIF
T
C
DVG
TP
T
V
W
AA
RY
-
LKMNG
K
R
RL
L
G
S
F
--------
NH
G
S
M
A
N
AM
P
Q
A
L
GA
QA
T
E
P
ERQ
VV
A
MC
GDG
GFS
M
LMG
D
FL
S
VV
Q
MK
LPV
K
I
I
VF
NN
SV
LG
F
V
A
-
--ME
M
KAGGYLTDGTELHD
-----------
TN
F
AR
I
A
E
A
C
G
IT
G
IR
V
EKAS
E
IDE
AL
QRAFSI
---
DG
P
VL
V
D
V
V
VA
KE
--------
E
LAI
P
P
Q
IK
fig|386585.9.peg.1073
Escherichia coli O157:H7 str. Sakai (9-539/572)
I
A
KT
L
ESA
GV
KR
I
W
G
VT
G
DS
L
NG
L
S
D
S
L
NRM
-
G
T
I
E
W
M
ST
RHE
E
V
A
AFA
A
G
A
E
A
QLS
G
E
L
A
V
--
C
AGS
C
GPG
N
LH
L
I
N
GL
F
D
C
HR
N
HV
P
VL
A
I
A
A
HIPSSE
IG
--
S
G
Y
FQE
T
H
PQ
--------
ELFRECS
H
YCE
LV
SSP
E
Q
I
P
QV
L
AI
A
MRK
A
V
L
-
N
R
-
G
V
S
V
V
V
LP
G
DV
ALKPA---
---
PEGATTHWYHAPQ
P
VVTPEEEE
L
RK
L
AQL
L
RY
S
SN
I
A
L
MC
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
IVHA
L
R
G
KE
HV
E
YD
N
P
YDV
GM
T
G
L
I
G
FSSGFHT
M
M
NAD
T
L
VL
L
G
T
Q
F
PY
R
A------
F
Y
P
T
D
A
KI
I
Q
IDI
N
P
A
S
I
GAHSKVD
M
A
L
VGD
IKST
L
RA
LL
PL
V
EEKADRK
F
L
D
--
--
-
-
K
ALEDY
R
DARKGLDDLAKPS
E
----------------------------
K
A
IHPQYLAQQ
I
SH
----
FAADDAIF
T
C
DVG
TP
T
V
W
AA
RY
-
LKMNG
K
R
RL
L
G
S
F
--------
NH
G
S
M
A
N
AM
P
Q
A
L
GA
QA
T
E
P
ERQ
VV
A
MC
GDG
GFS
M
LMG
D
FL
S
VV
Q
MK
LPV
K
I
I
VF
NN
SV
LG
F
V
A
-
--ME
M
KAGGYLTDGTELHD
-----------
TN
F
AR
I
A
E
A
C
G
IT
G
IR
V
EKAS
E
IDE
AL
QRAFSI
---
DG
P
VL
V
D
V
V
VA
KE
--------
E
LAI
P
P
Q
IK
fig|544404.4.peg.984
Escherichia coli O157:H7 str. TW14359 (9-539/572)
I
A
KT
L
ESA
GV
KR
I
W
G
VT
G
DS
L
NG
L
S
D
S
L
NRM
-
G
T
I
E
W
M
ST
RHE
E
V
A
AFA
A
G
A
E
A
QLS
G
E
L
A
V
--
C
AGS
C
GPG
N
LH
L
I
N
GL
F
D
C
HR
N
HV
P
VL
A
I
A
A
HIPSSE
IG
--
S
G
Y
FQE
T
H
PQ
--------
ELFRECS
H
YCE
LV
SSP
E
Q
I
P
QV
L
AI
A
MRK
A
V
L
-
N
R
-
G
V
S
V
V
V
LP
G
DV
ALKPA---
---
PEGATTHWYHAPQ
P
VVTPEEEE
L
RK
L
AQL
L
RY
S
SN
I
A
L
MC
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
IVHA
L
R
G
KE
HV
E
YD
N
P
YDV
GM
T
G
L
I
G
FSSGFHT
M
M
NAD
T
L
VL
L
G
T
Q
F
PY
R
A------
F
Y
P
T
D
A
KI
I
Q
IDI
N
P
A
S
I
GAHSKVD
M
A
L
VGD
IKST
L
RA
LL
PL
V
EEKADRK
F
L
D
--
--
-
-
K
ALEDY
R
DARKGLDDLAKPS
E
----------------------------
K
A
IHPQYLAQQ
I
SH
----
FAADDAIF
T
C
DVG
TP
T
V
W
AA
RY
-
LKMNG
K
R
RL
L
G
S
F
--------
NH
G
S
M
A
N
AM
P
Q
A
L
GA
QA
T
E
P
ERQ
VV
A
MC
GDG
GFS
M
LMG
D
FL
S
VV
Q
MK
LPV
K
I
I
VF
NN
SV
LG
F
V
A
-
--ME
M
KAGGYLTDGTELHD
-----------
TN
F
AR
I
A
E
A
C
G
IT
G
IR
V
EKAS
E
IDE
AL
QRAFSI
---
DG
P
VL
V
D
V
V
VA
KE
--------
E
LAI
P
P
Q
IK
fig|502346.5.peg.232
Escherichia coli O157:H7 str. TW14588 (9-539/572)
I
A
KT
L
ESA
GV
KR
I
W
G
VT
G
DS
L
NG
L
S
D
S
L
NRM
-
G
T
I
E
W
M
ST
RHE
E
V
A
AFA
A
G
A
E
A
QLS
G
E
L
A
V
--
C
AGS
C
GPG
N
LH
L
I
N
GL
F
D
C
HR
N
HV
P
VL
A
I
A
A
HIPSSE
IG
--
S
G
Y
FQE
T
H
PQ
--------
ELFRECS
H
YCE
LV
SSP
E
Q
I
P
QV
L
AI
A
MRK
A
V
L
-
N
R
-
G
V
S
V
V
V
LP
G
DV
ALKPA---
---
PEGATTHWYHAPQ
P
VVTPEEEE
L
RK
L
AQL
L
RY
S
SN
I
A
L
MC
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
IVHA
L
R
G
KE
HV
E
YD
N
P
YDV
GM
T
G
L
I
G
FSSGFHT
M
M
NAD
T
L
VL
L
G
T
Q
F
PY
R
A------
F
Y
P
T
D
A
KI
I
Q
IDI
N
P
A
S
I
GAHSKVD
M
A
L
VGD
IKST
L
RA
LL
PL
V
EEKADRK
F
L
D
--
--
-
-
K
ALEDY
R
DARKGLDDLAKPS
E
----------------------------
K
A
IHPQYLAQQ
I
SH
----
FAADDAIF
T
C
DVG
TP
T
V
W
AA
RY
-
LKMNG
K
R
RL
L
G
S
F
--------
NH
G
S
M
A
N
AM
P
Q
A
L
GA
QA
T
E
P
ERQ
VV
A
MC
GDG
GFS
M
LMG
D
FL
S
VV
Q
MK
LPV
K
I
I
VF
NN
SV
LG
F
V
A
-
--ME
M
KAGGYLTDGTELHD
-----------
TN
F
AR
I
A
E
A
C
G
IT
G
IR
V
EKAS
E
IDE
AL
QRAFSI
---
DG
P
VL
V
D
V
V
VA
KE
--------
E
LAI
P
P
Q
IK
fig|701177.3.peg.1089
Escherichia coli O55:H7 str. CB9615 (9-539/572)
I
A
KT
L
ESA
GV
KR
I
W
G
VT
G
DS
L
NG
L
S
D
S
L
NRM
-
G
T
I
E
W
M
ST
RHE
E
V
A
AFA
A
G
A
E
A
QLS
G
E
L
A
V
--
C
AGS
C
GPG
N
LH
L
I
N
GL
F
D
C
HR
N
HV
P
VL
A
I
A
A
HIPSSE
IG
--
S
G
Y
FQE
T
H
PQ
--------
ELFRECS
H
YCE
LV
SSP
E
Q
I
P
QV
L
AI
A
MRK
A
V
L
-
N
R
-
G
V
S
V
V
V
LP
G
DV
ALKPA---
---
PEGATTHWYHAPQ
P
VVTPEEEE
L
RK
L
AQL
L
RY
S
SN
I
A
L
MC
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
IVHA
L
R
G
KE
HV
E
YD
N
P
YDV
GM
T
G
L
I
G
FSSGFHT
M
M
NAD
T
L
VL
L
G
T
Q
F
PY
R
A------
F
Y
P
T
D
A
KI
I
Q
IDI
N
P
A
S
I
GAHSKVD
M
A
L
VGD
IKST
L
RA
LL
PL
V
EEKADRK
F
L
D
--
--
-
-
K
ALEDY
R
DARKGLDDLAKPS
E
----------------------------
K
A
IHPQYLAQQ
I
SH
----
FAADDAIF
T
C
DVG
TP
T
V
W
AA
RY
-
LKMNG
K
R
RL
L
G
S
F
--------
NH
G
S
M
A
N
AM
P
Q
A
L
GA
QA
T
E
P
ERQ
VV
A
MC
GDG
GFS
M
LMG
D
FL
S
VV
Q
MK
LPV
K
I
I
VF
NN
SV
LG
F
V
A
-
--ME
M
KAGGYLTDGTELHD
-----------
TN
F
AR
I
A
E
A
C
G
IT
G
IR
V
EKAS
E
IDE
AL
QRAFSI
---
DG
P
VL
V
D
V
V
VA
KE
--------
E
LAI
P
P
Q
IK
fig|340184.3.peg.1276
Escherichia coli B7A (9-539/572)
I
A
KT
L
ESA
GV
KR
I
W
G
VT
G
DS
L
NG
L
S
D
S
L
NRM
-
G
T
I
E
W
M
ST
RHE
E
V
A
AFA
A
G
A
E
A
QLS
G
E
L
A
V
--
C
AGS
C
GPG
N
LH
L
I
N
GL
F
D
C
HR
N
HV
P
VL
A
I
A
A
HIPSSE
IG
--
S
G
Y
FQE
T
H
PQ
--------
ELFRECS
H
YCE
LV
SSP
E
Q
I
P
QV
L
AI
A
MRK
A
V
L
-
N
R
-
G
V
S
V
V
V
LP
G
DV
ALKPA---
---
PEGATTHWYHAPQ
P
IVTPEEEE
L
RK
L
AQL
L
RY
S
SN
I
A
L
MC
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
IVHA
L
R
G
KE
HV
E
YD
N
P
YDV
GM
T
G
L
I
G
FSSGFHT
M
M
NAD
T
L
VL
L
G
T
Q
F
PY
R
A------
F
Y
P
T
D
A
KI
I
Q
IDI
N
P
A
S
I
GAHSKVD
M
A
L
VGD
IKST
L
RA
LL
PL
V
EEKTDRK
F
L
D
--
--
-
-
K
ALEDY
R
DARKGLDDLAKPS
E
----------------------------
K
A
IHPQYLAQQ
I
SH
----
FAADDAIF
T
C
DVG
TP
T
V
W
AA
RY
-
LKMNG
K
R
RL
L
G
S
F
--------
NH
G
S
M
A
N
AM
P
Q
A
L
GA
QA
T
E
P
ERQ
VV
A
MC
GDG
GFS
M
LMG
D
FL
S
VV
Q
MK
LPV
K
IV
VF
NN
SV
LG
F
V
A
-
--ME
M
KAGGYLTDGTELHD
-----------
TN
F
AR
I
A
E
A
C
G
IT
G
IR
V
EKAS
E
VDE
AL
QRAFSI
---
DG
P
VL
V
D
V
V
VA
KE
--------
E
LAI
P
P
Q
IK
fig|340184.6.peg.1342
Escherichia coli B7A (9-539/572)
I
A
KT
L
ESA
GV
KR
I
W
G
VT
G
DS
L
NG
L
S
D
S
L
NRM
-
G
T
I
E
W
M
ST
RHE
E
V
A
AFA
A
G
A
E
A
QLS
G
E
L
A
V
--
C
AGS
C
GPG
N
LH
L
I
N
GL
F
D
C
HR
N
HV
P
VL
A
I
A
A
HIPSSE
IG
--
S
G
Y
FQE
T
H
PQ
--------
ELFRECS
H
YCE
LV
SSP
E
Q
I
P
QV
L
AI
A
MRK
A
V
L
-
N
R
-
G
V
S
V
V
V
LP
G
DV
ALKPA---
---
PEGATTHWYHAPQ
P
IVTPEEEE
L
RK
L
AQL
L
RY
S
SN
I
A
L
MC
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
IVHA
L
R
G
KE
HV
E
YD
N
P
YDV
GM
T
G
L
I
G
FSSGFHT
M
M
NAD
T
L
VL
L
G
T
Q
F
PY
R
A------
F
Y
P
T
D
A
KI
I
Q
IDI
N
P
A
S
I
GAHSKVD
M
A
L
VGD
IKST
L
RA
LL
PL
V
EEKTDRK
F
L
D
--
--
-
-
K
ALEDY
R
DARKGLDDLAKPS
E
----------------------------
K
A
IHPQYLAQQ
I
SH
----
FAADDAIF
T
C
DVG
TP
T
V
W
AA
RY
-
LKMNG
K
R
RL
L
G
S
F
--------
NH
G
S
M
A
N
AM
P
Q
A
L
GA
QA
T
E
P
ERQ
VV
A
MC
GDG
GFS
M
LMG
D
FL
S
VV
Q
MK
LPV
K
IV
VF
NN
SV
LG
F
V
A
-
--ME
M
KAGGYLTDGTELHD
-----------
TN
F
AR
I
A
E
A
C
G
IT
G
IR
V
EKAS
E
VDE
AL
QRAFSI
---
DG
P
VL
V
D
V
V
VA
KE
--------
E
LAI
P
P
Q
IK
fig|656408.3.peg.928
Escherichia coli H591 (9-539/572)
I
A
KT
L
ESA
GV
KR
I
W
G
VT
G
DS
L
NG
L
S
D
S
L
NRM
-
G
T
I
E
W
M
ST
RHE
E
V
A
AFA
A
G
A
E
A
QLS
G
E
L
A
V
--
C
AGS
C
GPG
N
LH
L
I
N
GL
F
D
C
HR
N
HV
P
VL
A
I
A
A
HIPSSE
IG
--
S
G
Y
FQE
T
H
PQ
--------
ELFRECS
H
YCE
LV
SSP
E
Q
I
P
QV
L
AI
A
MRK
A
V
L
-
N
R
-
G
V
S
V
V
V
LP
G
DV
ALKPA---
---
PEGATTHWYHAPQ
P
IVTPEEEE
L
RK
L
AQL
L
RY
S
SN
I
A
L
MC
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
IVHA
L
R
G
KE
HV
E
YD
N
P
YDV
GM
T
G
L
I
G
FSSGFHT
M
M
NAD
T
L
VL
L
G
T
Q
F
PY
R
A------
F
Y
P
T
D
A
KI
I
Q
IDI
N
P
A
S
I
GAHSKVD
M
A
L
VGD
IKST
L
RA
LL
PL
V
EEKTDRK
F
L
D
--
--
-
-
K
ALEDY
R
DARKGLDDLAKPS
E
----------------------------
K
A
IHPQYLAQQ
I
SH
----
FAADDAIF
T
C
DVG
TP
T
V
W
AA
RY
-
LKMNG
K
R
RL
L
G
S
F
--------
NH
G
S
M
A
N
AM
P
Q
A
L
GA
QA
T
E
P
ERQ
VV
A
MC
GDG
GFS
M
LMG
D
FL
S
VV
Q
MK
LPV
K
IV
VF
NN
SV
LG
F
V
A
-
--ME
M
KAGGYLTDGTELHD
-----------
TN
F
AR
I
A
E
A
C
G
IT
G
IR
V
EKAS
E
VDE
AL
QRAFSI
---
DG
P
VL
V
D
V
V
VA
KE
--------
E
LAI
P
P
Q
IK
fig|585034.4.peg.900
Escherichia coli IAI1 (9-539/572)
I
A
KT
L
ESA
GV
KR
I
W
G
VT
G
DS
L
NG
L
S
D
S
L
NRM
-
G
T
I
E
W
M
ST
RHE
E
V
A
AFA
A
G
A
E
A
QLS
G
E
L
A
V
--
C
AGS
C
GPG
N
LH
L
I
N
GL
F
D
C
HR
N
HV
P
VL
A
I
A
A
HIPSSE
IG
--
S
G
Y
FQE
T
H
PQ
--------
ELFRECS
H
YCE
LV
SSP
E
Q
I
P
QV
L
AI
A
MRK
A
V
L
-
N
R
-
G
V
S
V
V
V
LP
G
DV
ALKPA---
---
PEGATTHWYHAPQ
P
IVTPEEEE
L
RK
L
AQL
L
RY
S
SN
I
A
L
MC
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
IVHA
L
R
G
KE
HV
E
YD
N
P
YDV
GM
T
G
L
I
G
FSSGFHT
M
M
NAD
T
L
VL
L
G
T
Q
F
PY
R
A------
F
Y
P
T
D
A
KI
I
Q
IDI
N
P
A
S
I
GAHSKVD
M
A
L
VGD
IKST
L
RA
LL
PL
V
EEKTDRK
F
L
D
--
--
-
-
K
ALEDY
R
DARKGLDDLAKPS
E
----------------------------
K
A
IHPQYLAQQ
I
SH
----
FAADDAIF
T
C
DVG
TP
T
V
W
AA
RY
-
LKMNG
K
R
RL
L
G
S
F
--------
NH
G
S
M
A
N
AM
P
Q
A
L
GA
QA
T
E
P
ERQ
VV
A
MC
GDG
GFS
M
LMG
D
FL
S
VV
Q
MK
LPV
K
IV
VF
NN
SV
LG
F
V
A
-
--ME
M
KAGGYLTDGTELHD
-----------
TN
F
AR
I
A
E
A
C
G
IT
G
IR
V
EKAS
E
VDE
AL
QRAFSI
---
DG
P
VL
V
D
V
V
VA
KE
--------
E
LAI
P
P
Q
IK
fig|585034.5.peg.896
Escherichia coli IAI1 (9-539/572)
I
A
KT
L
ESA
GV
KR
I
W
G
VT
G
DS
L
NG
L
S
D
S
L
NRM
-
G
T
I
E
W
M
ST
RHE
E
V
A
AFA
A
G
A
E
A
QLS
G
E
L
A
V
--
C
AGS
C
GPG
N
LH
L
I
N
GL
F
D
C
HR
N
HV
P
VL
A
I
A
A
HIPSSE
IG
--
S
G
Y
FQE
T
H
PQ
--------
ELFRECS
H
YCE
LV
SSP
E
Q
I
P
QV
L
AI
A
MRK
A
V
L
-
N
R
-
G
V
S
V
V
V
LP
G
DV
ALKPA---
---
PEGATTHWYHAPQ
P
IVTPEEEE
L
RK
L
AQL
L
RY
S
SN
I
A
L
MC
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
IVHA
L
R
G
KE
HV
E
YD
N
P
YDV
GM
T
G
L
I
G
FSSGFHT
M
M
NAD
T
L
VL
L
G
T
Q
F
PY
R
A------
F
Y
P
T
D
A
KI
I
Q
IDI
N
P
A
S
I
GAHSKVD
M
A
L
VGD
IKST
L
RA
LL
PL
V
EEKTDRK
F
L
D
--
--
-
-
K
ALEDY
R
DARKGLDDLAKPS
E
----------------------------
K
A
IHPQYLAQQ
I
SH
----
FAADDAIF
T
C
DVG
TP
T
V
W
AA
RY
-
LKMNG
K
R
RL
L
G
S
F
--------
NH
G
S
M
A
N
AM
P
Q
A
L
GA
QA
T
E
P
ERQ
VV
A
MC
GDG
GFS
M
LMG
D
FL
S
VV
Q
MK
LPV
K
IV
VF
NN
SV
LG
F
V
A
-
--ME
M
KAGGYLTDGTELHD
-----------
TN
F
AR
I
A
E
A
C
G
IT
G
IR
V
EKAS
E
VDE
AL
QRAFSI
---
DG
P
VL
V
D
V
V
VA
KE
--------
E
LAI
P
P
Q
IK
fig|595495.4.peg.3381
Escherichia coli KO11 (9-539/572)
I
A
KT
L
ESA
GV
KR
I
W
G
VT
G
DS
L
NG
L
S
D
S
L
NRM
-
G
T
I
E
W
M
ST
RHE
E
V
A
AFA
A
G
A
E
A
QLS
G
E
L
A
V
--
C
AGS
C
GPG
N
LH
L
I
N
GL
F
D
C
HR
N
HV
P
VL
A
I
A
A
HIPSSE
IG
--
S
G
Y
FQE
T
H
PQ
--------
ELFRECS
H
YCE
LV
SSP
E
Q
I
P
QV
L
AI
A
MRK
A
V
L
-
N
R
-
G
V
S
V
V
V
LP
G
DV
ALKPA---
---
PEGATTHWYHAPQ
P
IVTPEEEE
L
RK
L
AQL
L
RY
S
SN
I
A
L
MC
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
IVHA
L
R
G
KE
HV
E
YD
N
P
YDV
GM
T
G
L
I
G
FSSGFHT
M
M
NAD
T
L
VL
L
G
T
Q
F
PY
R
A------
F
Y
P
T
D
A
KI
I
Q
IDI
N
P
A
S
I
GAHSKVD
M
A
L
VGD
IKST
L
RA
LL
PL
V
EEKTDRK
F
L
D
--
--
-
-
K
ALEDY
R
DARKGLDDLAKPS
E
----------------------------
K
A
IHPQYLAQQ
I
SH
----
FAADDAIF
T
C
DVG
TP
T
V
W
AA
RY
-
LKMNG
K
R
RL
L
G
S
F
--------
NH
G
S
M
A
N
AM
P
Q
A
L
GA
QA
T
E
P
ERQ
VV
A
MC
GDG
GFS
M
LMG
D
FL
S
VV
Q
MK
LPV
K
IV
VF
NN
SV
LG
F
V
A
-
--ME
M
KAGGYLTDGTELHD
-----------
TN
F
AR
I
A
E
A
C
G
IT
G
IR
V
EKAS
E
VDE
AL
QRAFSI
---
DG
P
VL
V
D
V
V
VA
KE
--------
E
LAI
P
P
Q
IK
fig|679207.4.peg.2035
Escherichia coli MS 107-1 (9-539/572)
I
A
KT
L
ESA
GV
KR
I
W
G
VT
G
DS
L
NG
L
S
D
S
L
NRM
-
G
T
I
E
W
M
ST
RHE
E
V
A
AFA
A
G
A
E
A
QLS
G
E
L
A
V
--
C
AGS
C
GPG
N
LH
L
I
N
GL
F
D
C
HR
N
HV
P
VL
A
I
A
A
HIPSSE
IG
--
S
G
Y
FQE
T
H
PQ
--------
ELFRECS
H
YCE
LV
SSP
E
Q
I
P
QV
L
AI
A
MRK
A
V
L
-
N
R
-
G
V
S
V
V
V
LP
G
DV
ALKPA---
---
PEGATTHWYHAPQ
P
IVTPEEEE
L
RK
L
AQL
L
RY
S
SN
I
A
L
MC
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
IVHA
L
R
G
KE
HV
E
YD
N
P
YDV
GM
T
G
L
I
G
FSSGFHT
M
M
NAD
T
L
VL
L
G
T
Q
F
PY
R
A------
F
Y
P
T
D
A
KI
I
Q
IDI
N
P
A
S
I
GAHSKVD
M
A
L
VGD
IKST
L
RA
LL
PL
V
EEKTDRK
F
L
D
--
--
-
-
K
ALEDY
R
DARKGLDDLAKPS
E
----------------------------
K
A
IHPQYLAQQ
I
SH
----
FAADDAIF
T
C
DVG
TP
T
V
W
AA
RY
-
LKMNG
K
R
RL
L
G
S
F
--------
NH
G
S
M
A
N
AM
P
Q
A
L
GA
QA
T
E
P
ERQ
VV
A
MC
GDG
GFS
M
LMG
D
FL
S
VV
Q
MK
LPV
K
IV
VF
NN
SV
LG
F
V
A
-
--ME
M
KAGGYLTDGTELHD
-----------
TN
F
AR
I
A
E
A
C
G
IT
G
IR
V
EKAS
E
VDE
AL
QRAFSI
---
DG
P
VL
V
D
V
V
VA
KE
--------
E
LAI
P
P
Q
IK
fig|679206.4.peg.3777
Escherichia coli MS 119-7 (9-539/572)
I
A
KT
L
ESA
GV
KR
I
W
G
VT
G
DS
L
NG
L
S
D
S
L
NRM
-
G
T
I
E
W
M
ST
RHE
E
V
A
AFA
A
G
A
E
A
QLS
G
E
L
A
V
--
C
AGS
C
GPG
N
LH
L
I
N
GL
F
D
C
HR
N
HV
P
VL
A
I
A
A
HIPSSE
IG
--
S
G
Y
FQE
T
H
PQ
--------
ELFRECS
H
YCE
LV
SSP
E
Q
I
P
QV
L
AI
A
MRK
A
V
L
-
N
R
-
G
V
S
V
V
V
LP
G
DV
ALKPA---
---
PEGATTHWYHAPQ
P
IVTPEEEE
L
RK
L
AQL
L
RY
S
SN
I
A
L
MC
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
IVHA
L
R
G
KE
HV
E
YD
N
P
YDV
GM
T
G
L
I
G
FSSGFHT
M
M
NAD
T
L
VL
L
G
T
Q
F
PY
R
A------
F
Y
P
T
D
A
KI
I
Q
IDI
N
P
A
S
I
GAHSKVD
M
A
L
VGD
IKST
L
RA
LL
PL
V
EEKTDRK
F
L
D
--
--
-
-
K
ALEDY
R
DARKGLDDLAKPS
E
----------------------------
K
A
IHPQYLAQQ
I
SH
----
FAADDAIF
T
C
DVG
TP
T
V
W
AA
RY
-
LKMNG
K
R
RL
L
G
S
F
--------
NH
G
S
M
A
N
AM
P
Q
A
L
GA
QA
T
E
P
ERQ
VV
A
MC
GDG
GFS
M
LMG
D
FL
S
VV
Q
MK
LPV
K
IV
VF
NN
SV
LG
F
V
A
-
--ME
M
KAGGYLTDGTELHD
-----------
TN
F
AR
I
A
E
A
C
G
IT
G
IR
V
EKAS
E
VDE
AL
QRAFSI
---
DG
P
VL
V
D
V
V
VA
KE
--------
E
LAI
P
P
Q
IK
fig|679204.3.peg.2467
Escherichia coli MS 145-7 (9-539/572)
I
A
KT
L
ESA
GV
KR
I
W
G
VT
G
DS
L
NG
L
S
D
S
L
NRM
-
G
T
I
E
W
M
ST
RHE
E
V
A
AFA
A
G
A
E
A
QLS
G
E
L
A
V
--
C
AGS
C
GPG
N
LH
L
I
N
GL
F
D
C
HR
N
HV
P
VL
A
I
A
A
HIPSSE
IG
--
S
G
Y
FQE
T
H
PQ
--------
ELFRECS
H
YCE
LV
SSP
E
Q
I
P
QV
L
AI
A
MRK
A
V
L
-
N
R
-
G
V
S
V
V
V
LP
G
DV
ALKPA---
---
PEGATTHWYHAPQ
P
IVTPEEEE
L
RK
L
AQL
L
RY
S
SN
I
A
L
MC
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
IVHA
L
R
G
KE
HV
E
YD
N
P
YDV
GM
T
G
L
I
G
FSSGFHT
M
M
NAD
T
L
VL
L
G
T
Q
F
PY
R
A------
F
Y
P
T
D
A
KI
I
Q
IDI
N
P
A
S
I
GAHSKVD
M
A
L
VGD
IKST
L
RA
LL
PL
V
EEKTDRK
F
L
D
--
--
-
-
K
ALEDY
R
DARKGLDDLAKPS
E
----------------------------
K
A
IHPQYLAQQ
I
SH
----
FAADDAIF
T
C
DVG
TP
T
V
W
AA
RY
-
LKMNG
K
R
RL
L
G
S
F
--------
NH
G
S
M
A
N
AM
P
Q
A
L
GA
QA
T
E
P
ERQ
VV
A
MC
GDG
GFS
M
LMG
D
FL
S
VV
Q
MK
LPV
K
IV
VF
NN
SV
LG
F
V
A
-
--ME
M
KAGGYLTDGTELHD
-----------
TN
F
AR
I
A
E
A
C
G
IT
G
IR
V
EKAS
E
VDE
AL
QRAFSI
---
DG
P
VL
V
D
V
V
VA
KE
--------
E
LAI
P
P
Q
IK
fig|656443.3.peg.1154
Escherichia coli TA271 (9-539/572)
I
A
KT
L
ESA
GV
KR
I
W
G
VT
G
DS
L
NG
L
S
D
S
L
NRM
-
G
T
I
E
W
M
ST
RHE
E
V
A
AFA
A
G
A
E
A
QLS
G
E
L
A
V
--
C
AGS
C
GPG
N
LH
L
I
N
GL
F
D
C
HR
N
HV
P
VL
A
I
A
A
HIPSSE
IG
--
S
G
Y
FQE
T
H
PQ
--------
ELFRECS
H
YCE
LV
SSP
E
Q
I
P
QV
L
AI
A
MRK
A
V
L
-
N
R
-
G
V
S
V
V
V
LP
G
DV
ALKPA---
---
PEGATTHWYHAPQ
P
IVTPEEEE
L
RK
L
AQL
L
RY
S
SN
I
A
L
MC
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
IVHA
L
R
G
KE
HV
E
YD
N
P
YDV
GM
T
G
L
I
G
FSSGFHT
M
M
NAD
T
L
VL
L
G
T
Q
F
PY
R
A------
F
Y
P
T
D
A
KI
I
Q
IDI
N
P
A
S
I
GAHSKVD
M
A
L
VGD
IKST
L
RA
LL
PL
V
EEKTDRK
F
L
D
--
--
-
-
K
ALEDY
R
DARKGLDDLAKPS
E
----------------------------
K
A
IHPQYLAQQ
I
SH
----
FAADDAIF
T
C
DVG
TP
T
V
W
AA
RY
-
LKMNG
K
R
RL
L
G
S
F
--------
NH
G
S
M
A
N
AM
P
Q
A
L
GA
QA
T
E
P
ERQ
VV
A
MC
GDG
GFS
M
LMG
D
FL
S
VV
Q
MK
LPV
K
IV
VF
NN
SV
LG
F
V
A
-
--ME
M
KAGGYLTDGTELHD
-----------
TN
F
AR
I
A
E
A
C
G
IT
G
IR
V
EKAS
E
VDE
AL
QRAFSI
---
DG
P
VL
V
D
V
V
VA
KE
--------
E
LAI
P
P
Q
IK
fig|566546.3.peg.1907
Escherichia coli W (9-539/572)
I
A
KT
L
ESA
GV
KR
I
W
G
VT
G
DS
L
NG
L
S
D
S
L
NRM
-
G
T
I
E
W
M
ST
RHE
E
V
A
AFA
A
G
A
E
A
QLS
G
E
L
A
V
--
C
AGS
C
GPG
N
LH
L
I
N
GL
F
D
C
HR
N
HV
P
VL
A
I
A
A
HIPSSE
IG
--
S
G
Y
FQE
T
H
PQ
--------
ELFRECS
H
YCE
LV
SSP
E
Q
I
P
QV
L
AI
A
MRK
A
V
L
-
N
R
-
G
V
S
V
V
V
LP
G
DV
ALKPA---
---
PEGATTHWYHAPQ
P
IVTPEEEE
L
RK
L
AQL
L
RY
S
SN
I
A
L
MC
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
IVHA
L
R
G
KE
HV
E
YD
N
P
YDV
GM
T
G
L
I
G
FSSGFHT
M
M
NAD
T
L
VL
L
G
T
Q
F
PY
R
A------
F
Y
P
T
D
A
KI
I
Q
IDI
N
P
A
S
I
GAHSKVD
M
A
L
VGD
IKST
L
RA
LL
PL
V
EEKTDRK
F
L
D
--
--
-
-
K
ALEDY
R
DARKGLDDLAKPS
E
----------------------------
K
A
IHPQYLAQQ
I
SH
----
FAADDAIF
T
C
DVG
TP
T
V
W
AA
RY
-
LKMNG
K
R
RL
L
G
S
F
--------
NH
G
S
M
A
N
AM
P
Q
A
L
GA
QA
T
E
P
ERQ
VV
A
MC
GDG
GFS
M
LMG
D
FL
S
VV
Q
MK
LPV
K
IV
VF
NN
SV
LG
F
V
A
-
--ME
M
KAGGYLTDGTELHD
-----------
TN
F
AR
I
A
E
A
C
G
IT
G
IR
V
EKAS
E
VDE
AL
QRAFSI
---
DG
P
VL
V
D
V
V
VA
KE
--------
E
LAI
P
P
Q
IK
fig|566546.4.peg.969
Escherichia coli W (9-539/572)
I
A
KT
L
ESA
GV
KR
I
W
G
VT
G
DS
L
NG
L
S
D
S
L
NRM
-
G
T
I
E
W
M
ST
RHE
E
V
A
AFA
A
G
A
E
A
QLS
G
E
L
A
V
--
C
AGS
C
GPG
N
LH
L
I
N
GL
F
D
C
HR
N
HV
P
VL
A
I
A
A
HIPSSE
IG
--
S
G
Y
FQE
T
H
PQ
--------
ELFRECS
H
YCE
LV
SSP
E
Q
I
P
QV
L
AI
A
MRK
A
V
L
-
N
R
-
G
V
S
V
V
V
LP
G
DV
ALKPA---
---
PEGATTHWYHAPQ
P
IVTPEEEE
L
RK
L
AQL
L
RY
S
SN
I
A
L
MC
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
IVHA
L
R
G
KE
HV
E
YD
N
P
YDV
GM
T
G
L
I
G
FSSGFHT
M
M
NAD
T
L
VL
L
G
T
Q
F
PY
R
A------
F
Y
P
T
D
A
KI
I
Q
IDI
N
P
A
S
I
GAHSKVD
M
A
L
VGD
IKST
L
RA
LL
PL
V
EEKTDRK
F
L
D
--
--
-
-
K
ALEDY
R
DARKGLDDLAKPS
E
----------------------------
K
A
IHPQYLAQQ
I
SH
----
FAADDAIF
T
C
DVG
TP
T
V
W
AA
RY
-
LKMNG
K
R
RL
L
G
S
F
--------
NH
G
S
M
A
N
AM
P
Q
A
L
GA
QA
T
E
P
ERQ
VV
A
MC
GDG
GFS
M
LMG
D
FL
S
VV
Q
MK
LPV
K
IV
VF
NN
SV
LG
F
V
A
-
--ME
M
KAGGYLTDGTELHD
-----------
TN
F
AR
I
A
E
A
C
G
IT
G
IR
V
EKAS
E
VDE
AL
QRAFSI
---
DG
P
VL
V
D
V
V
VA
KE
--------
E
LAI
P
P
Q
IK
fig|685038.3.peg.797
Escherichia coli O83:H1 str. NRG 857C (9-539/572)
I
A
KT
L
ESA
GV
KR
I
W
G
VT
G
DS
L
NG
L
S
D
S
L
NRM
-
G
T
I
E
W
M
ST
RHE
E
V
A
AFA
A
G
A
E
A
QLS
G
E
L
A
V
--
C
AGS
C
GPG
N
LH
L
I
N
GL
F
D
C
HR
N
HV
P
VL
A
I
A
A
HIPSSE
IG
--
S
G
Y
FQE
T
H
PQ
--------
ELFRECS
H
YCE
LV
SSP
E
Q
I
P
QV
L
AI
A
MRK
A
V
L
-
N
R
-
G
V
S
V
V
V
LP
G
DV
ALKPA---
---
PEGATTHWYHAPQ
P
VVTPEEEE
L
RK
L
AQL
L
RY
S
SN
I
A
L
MC
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
IVHA
L
R
G
KE
HV
E
YD
N
P
YDV
GM
T
G
L
I
G
FSSGFHT
M
M
NAD
T
L
VL
L
G
T
Q
F
PY
R
A------
F
Y
P
T
D
A
KI
I
Q
IDI
N
P
A
S
I
GAHSKVD
M
A
L
VGD
IKST
L
RA
LL
PL
V
EEKTERN
F
L
D
--
--
-
-
K
ALEDY
R
DARKGLDDLAKPS
E
----------------------------
K
A
IHPQYLAQQ
I
SH
----
FAADDAIF
T
C
DVG
TP
T
V
W
AA
RY
-
LKMNG
K
R
RL
L
G
S
F
--------
NH
G
S
M
A
N
AM
P
Q
A
L
GA
QA
T
E
P
ERQ
VV
A
MC
GDG
GFS
M
LMG
D
FL
S
VV
Q
MK
LPV
K
I
I
VF
NN
SV
LG
F
V
A
-
--ME
M
KAGGYLTDGTELHD
-----------
TN
F
AR
I
A
E
A
C
G
IT
G
IR
V
EKAS
E
IDE
AL
QRAFSI
---
DG
P
VL
V
D
V
V
VA
KE
--------
E
LAI
P
P
Q
IK
fig|6666666.5357.peg.3854
Escherichia coli TY-2482 (9-539/572)
I
A
KT
L
ESA
GV
KR
I
W
G
VT
G
DS
L
NG
L
S
D
S
L
NRM
-
G
T
I
E
W
M
ST
RHE
E
V
A
AFA
A
G
A
E
A
QLS
G
E
L
A
V
--
C
AGS
C
GPG
N
LH
L
I
N
GL
F
D
C
HR
N
HV
P
VL
A
I
A
A
HIPSSE
IG
--
S
G
Y
FQE
T
H
PQ
--------
ELFRECS
H
YCE
LV
SSP
E
Q
I
P
QV
L
AI
A
MRK
A
V
L
-
N
R
-
G
V
S
V
V
V
LP
G
DV
ALKPA---
---
PEGATTHWYHAPQ
P
VVTPEEEE
L
RK
L
AQL
L
RY
S
SN
I
A
L
MC
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
IVHA
L
R
G
KE
HA
E
YD
N
P
YDV
GM
T
G
L
I
G
FSSGFHT
M
M
NAD
T
L
VL
L
G
T
Q
F
PY
R
A------
F
Y
P
T
D
A
KI
I
Q
IDI
N
P
A
S
I
GAHSKVD
M
A
L
VGD
IKST
L
RA
LL
PL
V
EEKTDRK
F
L
D
--
--
-
-
K
ALEDY
R
DARKGLDDLAKPS
E
----------------------------
K
A
IHPQYLAQQ
I
SH
----
FAADDAIF
T
C
DVG
TP
T
V
W
AA
RY
-
LKMNG
K
R
RL
L
G
S
F
--------
NH
G
S
M
A
N
AM
P
Q
A
L
GA
QA
T
E
P
ERQ
VV
A
MC
GDG
GFS
M
LMG
D
FL
S
VV
Q
MK
LPV
K
IV
VF
NN
SV
LG
F
V
A
-
--ME
M
KAGGYLTDGTELHD
-----------
TN
F
AR
I
A
E
A
C
G
IT
G
IR
V
EKAS
E
VDE
AL
QRAFSI
---
DG
P
VL
V
D
V
V
VA
KE
--------
E
LAI
P
P
Q
IK
fig|585055.6.peg.930
Escherichia coli 55989 (9-539/572)
I
A
KT
L
ESA
GV
KR
I
W
G
VT
G
DS
L
NG
L
S
D
S
L
NRM
-
G
T
I
E
W
M
ST
RHE
E
V
A
AFA
A
G
A
E
A
QLS
G
E
L
A
V
--
C
AGS
C
GPG
N
LH
L
I
N
GL
F
D
C
HR
N
HV
P
VL
A
I
A
A
HIPSSE
IG
--
S
G
Y
FQE
T
H
PQ
--------
ELFRECS
H
YCE
LV
SSP
E
Q
I
P
QV
L
AI
A
MRK
A
V
L
-
N
R
-
G
V
S
V
V
V
LP
G
DV
ALKPA---
---
PEGATTHWYHAPQ
P
VVTPEEEE
L
RK
L
AQL
L
RY
S
SN
I
A
L
MC
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
IVHA
L
R
G
KE
HA
E
YD
N
P
YDV
GM
T
G
L
I
G
FSSGFHT
M
M
NAD
T
L
VL
L
G
T
Q
F
PY
R
A------
F
Y
P
T
D
A
KI
I
Q
IDI
N
P
A
S
I
GAHSKVD
M
A
L
VGD
IKST
L
RA
LL
PL
V
EEKTDRK
F
L
D
--
--
-
-
K
ALEDY
R
DARKGLDDLAKPS
E
----------------------------
K
A
IHPQYLAQQ
I
SH
----
FAADDAIF
T
C
DVG
TP
T
V
W
AA
RY
-
LKMNG
K
R
RL
L
G
S
F
--------
NH
G
S
M
A
N
AM
P
Q
A
L
GA
QA
T
E
P
ERQ
VV
A
MC
GDG
GFS
M
LMG
D
FL
S
VV
Q
MK
LPV
K
IV
VF
NN
SV
LG
F
V
A
-
--ME
M
KAGGYLTDGTELHD
-----------
TN
F
AR
I
A
E
A
C
G
IT
G
IR
V
EKAS
E
VDE
AL
QRAFSI
---
DG
P
VL
V
D
V
V
VA
KE
--------
E
LAI
P
P
Q
IK
fig|585055.8.peg.933
Escherichia coli 55989 (9-539/572)
I
A
KT
L
ESA
GV
KR
I
W
G
VT
G
DS
L
NG
L
S
D
S
L
NRM
-
G
T
I
E
W
M
ST
RHE
E
V
A
AFA
A
G
A
E
A
QLS
G
E
L
A
V
--
C
AGS
C
GPG
N
LH
L
I
N
GL
F
D
C
HR
N
HV
P
VL
A
I
A
A
HIPSSE
IG
--
S
G
Y
FQE
T
H
PQ
--------
ELFRECS
H
YCE
LV
SSP
E
Q
I
P
QV
L
AI
A
MRK
A
V
L
-
N
R
-
G
V
S
V
V
V
LP
G
DV
ALKPA---
---
PEGATTHWYHAPQ
P
VVTPEEEE
L
RK
L
AQL
L
RY
S
SN
I
A
L
MC
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
IVHA
L
R
G
KE
HA
E
YD
N
P
YDV
GM
T
G
L
I
G
FSSGFHT
M
M
NAD
T
L
VL
L
G
T
Q
F
PY
R
A------
F
Y
P
T
D
A
KI
I
Q
IDI
N
P
A
S
I
GAHSKVD
M
A
L
VGD
IKST
L
RA
LL
PL
V
EEKTDRK
F
L
D
--
--
-
-
K
ALEDY
R
DARKGLDDLAKPS
E
----------------------------
K
A
IHPQYLAQQ
I
SH
----
FAADDAIF
T
C
DVG
TP
T
V
W
AA
RY
-
LKMNG
K
R
RL
L
G
S
F
--------
NH
G
S
M
A
N
AM
P
Q
A
L
GA
QA
T
E
P
ERQ
VV
A
MC
GDG
GFS
M
LMG
D
FL
S
VV
Q
MK
LPV
K
IV
VF
NN
SV
LG
F
V
A
-
--ME
M
KAGGYLTDGTELHD
-----------
TN
F
AR
I
A
E
A
C
G
IT
G
IR
V
EKAS
E
VDE
AL
QRAFSI
---
DG
P
VL
V
D
V
V
VA
KE
--------
E
LAI
P
P
Q
IK
fig|216592.1.peg.5117
Escherichia coli 042 (9-539/572)
I
A
KT
L
ESA
GV
KR
I
W
G
VT
G
DS
L
NG
L
S
D
S
L
NRM
-
G
T
I
E
W
M
ST
RHE
E
V
A
AFA
A
G
A
E
A
QLS
G
E
L
A
V
--
C
AGS
C
GPG
N
LH
L
I
N
GL
F
D
C
HR
N
HV
P
VL
A
I
A
A
HIPSSE
IG
--
S
G
Y
FQE
T
H
PQ
--------
ELFRECS
H
YCE
LV
SSP
E
Q
I
P
QV
L
AI
A
MRK
A
V
L
-
N
R
-
G
V
S
V
V
V
LP
G
DV
ALKPA---
---
PEGATSHWYHAPQ
P
VVTPEEEE
L
RK
L
AQL
L
RY
S
SN
I
A
L
MC
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
IVHA
L
R
G
KE
HV
E
YD
N
P
YDV
GM
T
G
L
I
G
FSSGFHT
M
M
NAD
T
L
VL
L
G
T
Q
F
PY
R
A------
F
Y
P
T
D
A
KI
I
Q
IDI
N
P
A
S
I
GAHSKVD
M
A
L
VGD
IKST
L
RA
LL
PL
V
EEKTDRK
F
L
D
--
--
-
-
K
ALEDY
R
DARKGLDDLAKPS
E
----------------------------
K
A
IHPQYLAQQ
I
SH
----
FAADDAIF
T
C
DVG
TP
T
V
W
AA
RY
-
LKMNG
K
R
RL
L
G
S
F
--------
NH
G
S
M
A
N
AM
P
Q
A
L
GA
QA
T
E
P
ERQ
VV
A
MC
GDG
GFS
M
LMG
D
FL
S
VV
Q
MK
LPV
K
I
I
VF
NN
SV
LG
F
V
A
-
--ME
M
KAGGYLTDGTELHD
-----------
TN
F
AR
I
A
E
A
C
G
IT
G
IR
V
EKAS
E
IDE
AL
QRAFSI
---
DG
P
VL
V
D
V
V
VA
KE
--------
E
LAI
P
P
Q
IK
fig|216592.3.peg.994
Escherichia coli 042 (9-539/572)
I
A
KT
L
ESA
GV
KR
I
W
G
VT
G
DS
L
NG
L
S
D
S
L
NRM
-
G
T
I
E
W
M
ST
RHE
E
V
A
AFA
A
G
A
E
A
QLS
G
E
L
A
V
--
C
AGS
C
GPG
N
LH
L
I
N
GL
F
D
C
HR
N
HV
P
VL
A
I
A
A
HIPSSE
IG
--
S
G
Y
FQE
T
H
PQ
--------
ELFRECS
H
YCE
LV
SSP
E
Q
I
P
QV
L
AI
A
MRK
A
V
L
-
N
R
-
G
V
S
V
V
V
LP
G
DV
ALKPA---
---
PEGATSHWYHAPQ
P
VVTPEEEE
L
RK
L
AQL
L
RY
S
SN
I
A
L
MC
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
IVHA
L
R
G
KE
HV
E
YD
N
P
YDV
GM
T
G
L
I
G
FSSGFHT
M
M
NAD
T
L
VL
L
G
T
Q
F
PY
R
A------
F
Y
P
T
D
A
KI
I
Q
IDI
N
P
A
S
I
GAHSKVD
M
A
L
VGD
IKST
L
RA
LL
PL
V
EEKTDRK
F
L
D
--
--
-
-
K
ALEDY
R
DARKGLDDLAKPS
E
----------------------------
K
A
IHPQYLAQQ
I
SH
----
FAADDAIF
T
C
DVG
TP
T
V
W
AA
RY
-
LKMNG
K
R
RL
L
G
S
F
--------
NH
G
S
M
A
N
AM
P
Q
A
L
GA
QA
T
E
P
ERQ
VV
A
MC
GDG
GFS
M
LMG
D
FL
S
VV
Q
MK
LPV
K
I
I
VF
NN
SV
LG
F
V
A
-
--ME
M
KAGGYLTDGTELHD
-----------
TN
F
AR
I
A
E
A
C
G
IT
G
IR
V
EKAS
E
IDE
AL
QRAFSI
---
DG
P
VL
V
D
V
V
VA
KE
--------
E
LAI
P
P
Q
IK
fig|656379.3.peg.1720
Escherichia coli FVEC1302 (9-539/572)
I
A
KT
L
ESA
GV
KR
I
W
G
VT
G
DS
L
NG
L
S
D
S
L
NRM
-
G
T
I
E
W
M
ST
RHE
E
V
A
AFA
A
G
A
E
A
QLS
G
E
L
A
V
--
C
AGS
C
GPG
N
LH
L
I
N
GL
F
D
C
HR
N
HV
P
VL
A
I
A
A
HIPSSE
IG
--
S
G
Y
FQE
T
H
PQ
--------
ELFRECS
H
YCE
LV
SSP
E
Q
I
P
QV
L
AI
A
MRK
A
V
L
-
N
R
-
G
V
S
V
V
V
LP
G
DV
ALKPA---
---
PEGATTHWYHAPQ
P
VVTPEEEE
L
RK
L
AQL
L
RY
S
SN
I
A
L
MC
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
IVHA
L
R
G
KE
HV
E
YD
N
P
YDV
GM
T
G
L
I
G
FSSGFHT
M
M
NAD
T
L
VL
L
G
T
Q
F
PY
R
A------
F
Y
P
T
D
A
KI
I
Q
IDI
N
P
A
S
I
GAHSKVD
M
A
L
VGD
IKST
L
RA
LL
PL
V
EEKADRK
F
L
D
--
--
-
-
K
ALEDY
R
DARKGLDDLAKPS
E
----------------------------
K
A
IHPQYLAQQ
I
SH
----
FAADDAIF
T
C
DVG
TP
T
V
W
AA
RY
-
LKMNG
K
R
RL
L
G
S
F
--------
NH
G
S
M
A
N
AM
P
Q
A
L
GA
QA
T
E
P
ERQ
VV
A
MC
GDG
GFS
M
LMG
D
FL
S
VV
Q
MK
LPV
K
I
I
VF
NN
SV
LG
F
V
A
-
--ME
M
KAGGYLTDGTELHD
-----------
TN
F
AR
I
A
E
A
C
G
IT
G
IR
V
EKAS
E
VDE
AL
QRAFSI
---
DG
P
VL
V
D
V
V
VA
KE
--------
E
LAI
P
P
Q
IK
fig|656380.3.peg.1547
Escherichia coli FVEC1412 (9-539/572)
I
A
KT
L
ESA
GV
KR
I
W
G
VT
G
DS
L
NG
L
S
D
S
L
NRM
-
G
T
I
E
W
M
ST
RHE
E
V
A
AFA
A
G
A
E
A
QLS
G
E
L
A
V
--
C
AGS
C
GPG
N
LH
L
I
N
GL
F
D
C
HR
N
HV
P
VL
A
I
A
A
HIPSSE
IG
--
S
G
Y
FQE
T
H
PQ
--------
ELFRECS
H
YCE
LV
SSP
E
Q
I
P
QV
L
AI
A
MRK
A
V
L
-
N
R
-
G
V
S
V
V
V
LP
G
DV
ALKPA---
---
PEGATTHWYHAPQ
P
VVTPEEEE
L
RK
L
AQL
L
RY
S
SN
I
A
L
MC
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
IVHA
L
R
G
KE
HV
E
YD
N
P
YDV
GM
T
G
L
I
G
FSSGFHT
M
M
NAD
T
L
VL
L
G
T
Q
F
PY
R
A------
F
Y
P
T
D
A
KI
I
Q
IDI
N
P
A
S
I
GAHSKVD
M
A
L
VGD
IKST
L
RA
LL
PL
V
EEKADRK
F
L
D
--
--
-
-
K
ALEDY
R
DARKGLDDLAKPS
E
----------------------------
K
A
IHPQYLAQQ
I
SH
----
FAADDAIF
T
C
DVG
TP
T
V
W
AA
RY
-
LKMNG
K
R
RL
L
G
S
F
--------
NH
G
S
M
A
N
AM
P
Q
A
L
GA
QA
T
E
P
ERQ
VV
A
MC
GDG
GFS
M
LMG
D
FL
S
VV
Q
MK
LPV
K
I
I
VF
NN
SV
LG
F
V
A
-
--ME
M
KAGGYLTDGTELHD
-----------
TN
F
AR
I
A
E
A
C
G
IT
G
IR
V
EKAS
E
VDE
AL
QRAFSI
---
DG
P
VL
V
D
V
V
VA
KE
--------
E
LAI
P
P
Q
IK
fig|749549.3.peg.4954
Escherichia coli MS 198-1 (9-539/572)
I
A
KT
L
ESA
GV
KR
I
W
G
VT
G
DS
L
NG
L
S
D
S
L
NRM
-
G
T
I
E
W
M
ST
RHE
E
V
A
AFA
A
G
A
E
A
QLS
G
E
L
A
V
--
C
AGS
C
GPG
N
LH
L
I
N
GL
F
D
C
HR
N
HV
P
VL
A
I
A
A
HIPSSE
IG
--
S
G
Y
FQE
T
H
PQ
--------
ELFRECS
H
YCE
LV
SSP
E
Q
I
P
QV
L
AI
A
MRK
A
V
L
-
N
R
-
G
V
S
V
V
V
LP
G
DV
ALKPA---
---
PEGATTHWYHAPQ
P
VVTPEEEE
L
RK
L
AQL
L
RY
S
SN
I
A
L
MC
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
IVHA
L
R
G
KE
HV
E
YD
N
P
YDV
GM
T
G
L
I
G
FSSGFHT
M
M
NAD
T
L
VL
L
G
T
Q
F
PY
R
A------
F
Y
P
T
D
A
KI
I
Q
IDI
N
P
A
S
I
GAHSKVD
M
A
L
VGD
IKST
L
RA
LL
PL
V
EEKADRK
F
L
D
--
--
-
-
K
ALEDY
R
DARKGLDDLAKPS
E
----------------------------
K
A
IHPQYLAQQ
I
SH
----
FAADDAIF
T
C
DVG
TP
T
V
W
AA
RY
-
LKMNG
K
R
RL
L
G
S
F
--------
NH
G
S
M
A
N
AM
P
Q
A
L
GA
QA
T
E
P
ERQ
VV
A
MC
GDG
GFS
M
LMG
D
FL
S
VV
Q
MK
LPV
K
I
I
VF
NN
SV
LG
F
V
A
-
--ME
M
KAGGYLTDGTELHD
-----------
TN
F
AR
I
A
E
A
C
G
IT
G
IR
V
EKAS
E
VDE
AL
QRAFSI
---
DG
P
VL
V
D
V
V
VA
KE
--------
E
LAI
P
P
Q
IK
fig|585056.7.peg.1259
Escherichia coli UMN026 (9-539/572)
I
A
KT
L
ESA
GV
KR
I
W
G
VT
G
DS
L
NG
L
S
D
S
L
NRM
-
G
T
I
E
W
M
ST
RHE
E
V
A
AFA
A
G
A
E
A
QLS
G
E
L
A
V
--
C
AGS
C
GPG
N
LH
L
I
N
GL
F
D
C
HR
N
HV
P
VL
A
I
A
A
HIPSSE
IG
--
S
G
Y
FQE
T
H
PQ
--------
ELFRECS
H
YCE
LV
SSP
E
Q
I
P
QV
L
AI
A
MRK
A
V
L
-
N
R
-
G
V
S
V
V
V
LP
G
DV
ALKPA---
---
PEGATTHWYHAPQ
P
VVTPEEEE
L
RK
L
AQL
L
RY
S
SN
I
A
L
MC
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
IVHA
L
R
G
KE
HV
E
YD
N
P
YDV
GM
T
G
L
I
G
FSSGFHT
M
M
NAD
T
L
VL
L
G
T
Q
F
PY
R
A------
F
Y
P
T
D
A
KI
I
Q
IDI
N
P
A
S
I
GAHSKVD
M
A
L
VGD
IKST
L
RA
LL
PL
V
EEKADRK
F
L
D
--
--
-
-
K
ALEDY
R
DARKGLDDLAKPS
E
----------------------------
K
A
IHPQYLAQQ
I
SH
----
FAADDAIF
T
C
DVG
TP
T
V
W
AA
RY
-
LKMNG
K
R
RL
L
G
S
F
--------
NH
G
S
M
A
N
AM
P
Q
A
L
GA
QA
T
E
P
ERQ
VV
A
MC
GDG
GFS
M
LMG
D
FL
S
VV
Q
MK
LPV
K
I
I
VF
NN
SV
LG
F
V
A
-
--ME
M
KAGGYLTDGTELHD
-----------
TN
F
AR
I
A
E
A
C
G
IT
G
IR
V
EKAS
E
VDE
AL
QRAFSI
---
DG
P
VL
V
D
V
V
VA
KE
--------
E
LAI
P
P
Q
IK
fig|656393.3.peg.1631
Escherichia coli H299 (9-539/572)
I
A
KT
L
ESA
GV
KR
I
W
G
VT
G
DS
L
NG
L
S
D
S
L
NRM
-
G
T
I
E
W
M
ST
RHE
E
V
A
AFA
A
G
A
E
A
QLS
G
E
L
A
V
--
C
AGS
C
GPG
N
LH
L
I
N
GL
F
D
C
HR
N
HV
P
VL
A
I
A
A
HIPSSE
IG
--
S
G
Y
FQE
T
H
PQ
--------
ELFRECS
H
YCE
LV
SSP
E
Q
I
P
QV
L
AI
A
MRK
A
V
L
-
N
R
-
G
V
S
V
V
V
LP
G
DV
ALKPA---
---
PEGATTHWYHAPQ
P
VVTPEEEE
L
RK
L
AQL
L
RY
S
SN
I
A
L
MC
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
IVHA
L
R
G
KE
HV
E
YD
N
P
YDV
GM
T
G
L
I
G
FSSGFHT
M
M
NAD
T
L
VL
L
G
T
Q
F
PY
R
A------
F
Y
P
T
D
A
KI
I
Q
IDI
N
P
A
S
I
GAHSKVD
M
A
L
VGD
IKST
L
RA
LL
PL
V
EEKADRK
F
L
D
--
--
-
-
K
ALEDY
R
DARKGLDDLAKPS
E
----------------------------
K
A
IHPQYLAQQ
I
SH
----
FAADDAIF
T
C
DVG
TP
T
V
W
AA
RY
-
LKMNG
K
R
RL
L
G
S
F
--------
NH
G
S
M
A
N
AM
P
Q
A
L
GA
QA
T
E
P
ERQ
VV
A
MC
GDG
GFS
M
LMG
D
FL
S
VV
Q
MK
LPV
K
I
I
VF
NN
SV
LG
F
V
A
-
--ME
M
KAGGYLTDGTELHD
-----------
TN
F
AR
I
A
E
A
C
G
IT
G
IR
V
EKAS
E
VDE
AL
QRAFSI
---
DG
P
VM
V
D
V
V
VA
KE
--------
E
LAI
P
P
Q
IK
fig|670897.3.peg.4715
Escherichia coli 2362-75 (9-539/572)
I
A
KT
L
ESA
GV
KR
I
W
G
VT
G
DS
L
NG
L
S
D
S
L
NRM
-
G
T
I
E
W
M
ST
RHE
E
V
A
AFA
A
G
A
E
A
QLS
G
E
L
A
V
--
C
AGS
C
GPG
N
LH
L
I
N
GL
F
D
C
HR
N
HV
P
VL
A
I
A
A
HIPSSE
IG
--
S
G
Y
FQE
T
H
PQ
--------
ELFRECS
H
YCE
LV
SSP
E
Q
I
P
QV
L
AI
A
MRK
A
V
L
-
N
R
-
G
V
S
V
V
V
LP
G
DV
ALKPA---
---
PEGATTHWYHAPQ
P
VVTPEEEE
L
RK
L
AQL
L
RY
S
SN
I
A
L
MC
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
IVHA
L
R
G
KE
HV
E
YD
N
P
YDV
GM
T
G
L
I
G
FSSGFHT
M
M
NAD
T
L
VL
L
G
T
Q
F
PY
R
V------
F
Y
P
T
D
A
KI
I
Q
IDI
N
P
A
S
I
GTHSKVD
M
A
L
VGD
IKST
L
RA
LL
PL
V
EEKTERK
F
L
D
--
--
-
-
K
ALEDY
R
DARKGLDDLAKPS
E
----------------------------
K
A
IHPQYLAQQ
I
SH
----
FAADDAIF
T
C
DVG
TP
T
V
W
AA
RY
-
LKMNG
K
R
RL
L
G
S
F
--------
NH
G
S
M
A
N
AM
P
Q
A
L
GA
QA
T
E
P
ERQ
VV
A
MC
GDG
GFS
M
LMG
D
FL
S
VV
Q
MK
LPV
K
IV
VF
NN
SV
LG
F
V
A
-
--ME
M
KAGGYLTDGTELHD
-----------
TN
F
AR
I
A
E
A
C
G
IT
G
IR
V
EKAS
E
VDE
AL
QRAFSI
---
DG
P
VL
V
D
V
V
VA
KE
--------
E
LAI
P
P
Q
IK
fig|550677.3.peg.2144
Escherichia coli B354 (9-539/572)
I
A
KT
L
ESA
GV
KR
I
W
G
VT
G
DS
L
NG
L
S
D
S
L
NRM
-
G
T
I
E
W
M
ST
RHE
E
V
A
AFA
A
G
A
E
A
QLS
G
E
L
A
V
--
C
AGS
C
GPG
N
LH
L
I
N
GL
F
D
C
HR
N
HV
P
VL
A
I
A
A
HIPSSE
IG
--
S
G
Y
FQE
T
H
PQ
--------
ELFRECS
H
YCE
LV
SSP
E
Q
I
P
QV
L
AI
A
MRK
A
V
L
-
N
R
-
G
V
S
V
V
V
LP
G
DV
ALKPA---
---
PEGATSHWYHAPQ
P
VVTPEEEE
L
RK
L
AQL
L
RY
S
SN
I
A
L
MC
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
IVHA
L
R
G
KE
HV
E
YD
N
P
YDV
GM
T
G
L
I
G
FSSGFHT
M
M
NAD
T
L
VL
L
G
T
Q
F
PY
R
A------
F
Y
P
T
D
A
KI
I
Q
IDI
N
P
A
S
I
GAHSKVD
M
A
L
VGD
IKST
L
RA
LL
PL
V
EEKTDRK
F
L
D
--
--
-
-
K
ALEDY
R
DARKGLDDLAKPS
E
----------------------------
K
A
IHPQYLAQQ
I
SH
----
FAADDAIF
T
C
DVG
TP
T
V
W
AA
RY
-
LKMNG
K
R
RL
L
G
S
F
--------
NH
G
S
M
A
N
AM
P
Q
A
L
GA
QA
T
E
P
ERQ
VV
A
MC
GDG
GFS
M
LMG
D
FL
S
VV
Q
MK
LPV
K
I
I
VF
NN
SV
LG
F
V
A
-
--ME
M
KAGGYLTDGTELHD
-----------
TN
F
AR
I
A
E
A
C
G
IT
G
IR
V
EKAS
E
VDE
AL
QRAFSI
---
DG
P
VL
V
D
V
V
VA
KE
--------
E
LAI
P
P
Q
IK
fig|216593.1.peg.1517
Escherichia coli E2348/69 (9-539/572)
I
A
KT
L
ESA
GV
KR
I
W
G
VT
G
DS
L
NG
L
S
D
S
L
NRM
-
G
T
I
E
W
M
ST
RHE
E
V
A
AFA
A
G
A
E
A
QLS
G
E
L
A
V
--
C
AGS
C
GPG
N
LH
L
I
N
GL
F
D
C
HR
N
HV
P
VL
A
I
A
A
HIPSSE
IG
--
S
G
Y
FQE
T
H
PQ
--------
ELFRECS
H
YCE
LV
SSP
E
Q
I
P
QV
L
AI
A
MRK
A
V
L
-
N
R
-
G
V
S
V
V
V
LP
G
DV
ALKPA---
---
PEGATTHWYHAPQ
P
VVTPEEEE
L
RK
L
AQL
L
RY
S
SN
I
A
L
MC
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
IVHA
L
R
G
KE
HV
E
YD
N
P
YDV
GM
T
G
L
I
G
FSSGFHT
M
M
NAD
T
L
VL
L
G
T
Q
F
PY
R
V------
F
Y
P
T
D
A
KI
I
Q
IDI
N
P
A
S
I
GAHSKVD
M
A
L
VGD
IKST
L
RA
LL
PL
V
EEKTERK
F
L
D
--
--
-
-
K
ALEDY
R
DARKGLDDLAKPS
E
----------------------------
K
A
IHPQYLAQQ
I
SH
----
FAADDAIF
T
C
DVG
TP
T
V
W
AA
RY
-
LKMNG
K
R
RL
L
G
S
F
--------
NH
G
S
M
A
N
AM
P
Q
A
L
GA
QA
T
E
P
ERQ
VV
A
MC
GDG
GFS
M
LMG
D
FL
S
VV
Q
MK
LPV
K
IV
VF
NN
SV
LG
F
V
A
-
--ME
M
KAGGYLTDGTELHD
-----------
TN
F
AR
I
A
E
A
C
G
IT
G
IR
V
EKAS
E
VDE
AL
QRAFSI
---
DG
P
VL
V
D
V
V
VA
KE
--------
E
LAI
P
P
Q
IK
fig|656437.3.peg.1006
Escherichia coli TA143 (9-539/572)
I
A
KT
L
ESA
GV
KR
I
W
G
VT
G
DS
L
NG
L
S
D
S
L
NRM
-
G
T
I
E
W
M
ST
RHE
E
V
A
AFA
A
G
A
E
A
QLS
G
E
L
A
V
--
C
AGS
C
GPG
N
LH
L
I
N
GL
F
D
C
HR
N
HV
P
VL
A
I
A
A
HIPSSE
IG
--
S
G
Y
FQE
T
H
PQ
--------
ELFRECS
H
YCE
LV
SSP
E
Q
I
P
QV
L
AI
A
MRK
A
V
L
-
N
R
-
G
V
S
V
V
V
LP
G
DV
ALKPA---
---
PEGATSHWYHAPQ
P
VVTPEEEE
L
RK
L
AQL
L
RY
S
SN
I
A
L
MC
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
IVHA
L
R
G
KE
HV
E
YD
N
P
YDV
GM
T
G
L
I
G
FSSGFHT
M
M
NAD
T
L
VL
L
G
T
Q
F
PY
R
A------
F
Y
P
T
D
A
KI
I
Q
IDI
N
P
A
S
I
GAHSKVD
M
A
L
VGD
IKST
L
RA
LL
PL
V
EEKADRK
F
L
D
--
--
-
-
K
ALEDY
R
DARKGLDDLAKPS
E
----------------------------
K
A
IHPQYLAQQ
I
SH
----
FAADDAIF
T
C
DVG
TP
T
V
W
AA
RY
-
LKMNG
K
R
RL
L
G
S
F
--------
NH
G
S
M
A
N
AM
P
Q
A
L
GA
QA
T
E
P
ERQ
VV
A
MC
GDG
GFS
M
LMG
D
FL
S
VV
Q
MK
LPV
K
I
I
VF
NN
SV
LG
F
V
A
-
--ME
M
KAGGYLTDGTELHD
-----------
TN
F
AR
I
A
E
A
C
G
IT
G
IR
V
EKAS
E
VDE
AL
QRAFSI
---
DG
P
VL
V
D
V
V
VA
KE
--------
E
LAI
P
P
Q
IK
fig|405955.13.peg.834
Escherichia coli APEC O1 (9-539/572)
I
A
KT
L
ESA
GV
KR
I
W
G
VT
G
DS
L
NG
L
S
D
S
L
NRM
-
G
T
I
E
W
M
ST
RHE
E
V
A
AFA
A
G
A
E
A
QLS
G
E
L
A
V
--
C
AGS
C
GPG
N
LH
L
I
N
GL
F
D
C
HR
N
HV
P
VL
A
I
A
A
HIPSSE
IG
--
S
G
Y
FQE
T
H
PQ
--------
ELFRECS
H
YCE
LV
SSP
E
Q
I
P
QV
L
AI
A
MRK
A
V
L
-
N
R
-
G
V
S
V
V
V
LP
G
DV
ALKPA---
---
PEGATTHWYHAPQ
P
VVTPEEEE
L
RK
L
AQL
L
RY
S
SN
I
A
L
MC
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
IVHA
L
R
G
KE
HV
E
YD
N
P
YDV
GM
T
G
L
I
G
FSSGFHT
M
M
NAD
T
L
VL
L
G
T
Q
F
PY
R
V------
F
Y
P
T
D
A
KI
I
Q
IDI
N
P
A
S
I
GAHSKVD
M
A
L
VGD
IKST
L
RA
LL
PL
V
EEKTERK
F
L
D
--
--
-
-
K
ALEDY
R
DARKGLDDLAKPS
E
----------------------------
K
A
IHPQYLAQQ
I
SH
----
FAADDAIF
T
C
DVG
TP
T
V
W
AA
RY
-
LKMNG
K
R
RL
L
G
S
F
--------
NH
G
S
M
A
N
AM
P
Q
A
L
GA
QA
T
E
P
ERQ
VV
A
MC
GDG
GFS
M
LMG
D
FL
S
VV
Q
MK
LPV
K
I
I
VF
NN
SV
LG
F
V
A
-
--ME
M
KAGGYLTDGTELHD
-----------
TN
F
AR
I
A
E
A
C
G
IT
G
IR
V
EKAS
E
IDE
AL
QRAFSI
---
DG
P
VL
V
D
V
V
VA
KE
--------
E
LAI
P
P
Q
IK
fig|405955.9.peg.702
Escherichia coli APEC O1 (9-539/572)
I
A
KT
L
ESA
GV
KR
I
W
G
VT
G
DS
L
NG
L
S
D
S
L
NRM
-
G
T
I
E
W
M
ST
RHE
E
V
A
AFA
A
G
A
E
A
QLS
G
E
L
A
V
--
C
AGS
C
GPG
N
LH
L
I
N
GL
F
D
C
HR
N
HV
P
VL
A
I
A
A
HIPSSE
IG
--
S
G
Y
FQE
T
H
PQ
--------
ELFRECS
H
YCE
LV
SSP
E
Q
I
P
QV
L
AI
A
MRK
A
V
L
-
N
R
-
G
V
S
V
V
V
LP
G
DV
ALKPA---
---
PEGATTHWYHAPQ
P
VVTPEEEE
L
RK
L
AQL
L
RY
S
SN
I
A
L
MC
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
IVHA
L
R
G
KE
HV
E
YD
N
P
YDV
GM
T
G
L
I
G
FSSGFHT
M
M
NAD
T
L
VL
L
G
T
Q
F
PY
R
V------
F
Y
P
T
D
A
KI
I
Q
IDI
N
P
A
S
I
GAHSKVD
M
A
L
VGD
IKST
L
RA
LL
PL
V
EEKTERK
F
L
D
--
--
-
-
K
ALEDY
R
DARKGLDDLAKPS
E
----------------------------
K
A
IHPQYLAQQ
I
SH
----
FAADDAIF
T
C
DVG
TP
T
V
W
AA
RY
-
LKMNG
K
R
RL
L
G
S
F
--------
NH
G
S
M
A
N
AM
P
Q
A
L
GA
QA
T
E
P
ERQ
VV
A
MC
GDG
GFS
M
LMG
D
FL
S
VV
Q
MK
LPV
K
I
I
VF
NN
SV
LG
F
V
A
-
--ME
M
KAGGYLTDGTELHD
-----------
TN
F
AR
I
A
E
A
C
G
IT
G
IR
V
EKAS
E
IDE
AL
QRAFSI
---
DG
P
VL
V
D
V
V
VA
KE
--------
E
LAI
P
P
Q
IK
fig|331111.12.peg.1235
Escherichia coli E24377A (9-539/572)
I
A
KT
L
ESA
GV
KR
I
W
G
VT
G
DS
L
NG
L
S
D
S
L
NRM
-
G
T
I
E
W
M
ST
RHE
E
V
A
AFA
A
G
A
E
A
QLS
G
E
L
A
V
--
C
AGS
C
GPG
N
LH
L
I
N
GL
F
D
C
HR
N
HV
P
VL
A
I
A
A
HIPSSE
IG
--
S
G
Y
FQE
T
H
PQ
--------
ELFRECS
H
YCE
LV
SSP
E
Q
I
P
QV
L
AI
A
MRK
A
V
L
-
N
R
-
G
V
S
V
V
V
LP
G
DV
ALKPA---
---
PEGATTHWYHAPQ
P
IVTPEEEE
L
RK
L
AQL
L
RY
S
SN
I
A
L
MC
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
IVHA
L
R
G
KE
HV
E
YD
N
P
YDV
GM
T
G
L
I
G
FSSGFHT
M
M
NAD
T
L
VL
L
G
T
Q
F
PY
R
A------
F
Y
P
T
D
A
KI
I
Q
IDI
N
P
A
S
I
GAHSKVD
M
A
L
VGD
IKST
L
RA
LL
PL
V
EEKTDRK
F
L
D
--
--
-
-
T
ALEDY
R
DARKGLDDLAKPS
E
----------------------------
K
A
IHPQYLAQQ
I
SH
----
FAADDAIF
T
C
DVG
TP
T
V
W
AA
RY
-
LKMNG
K
R
RL
L
G
S
F
--------
NH
G
S
M
A
N
AM
P
Q
A
L
GA
QA
T
E
P
ERQ
VV
A
MC
GDG
GFS
M
LMG
D
FL
S
VV
Q
MK
LPV
K
IV
VF
NN
SV
LG
F
V
A
-
--ME
M
KAGGYLTDGTELHD
-----------
TN
F
AR
I
A
E
A
C
G
IT
G
IR
V
EKAS
E
VDE
AL
QRAFSI
---
DG
P
VL
V
D
V
V
VA
KE
--------
E
LAI
P
P
Q
IK
fig|331111.3.peg.3441
Escherichia coli E24377A (9-539/572)
I
A
KT
L
ESA
GV
KR
I
W
G
VT
G
DS
L
NG
L
S
D
S
L
NRM
-
G
T
I
E
W
M
ST
RHE
E
V
A
AFA
A
G
A
E
A
QLS
G
E
L
A
V
--
C
AGS
C
GPG
N
LH
L
I
N
GL
F
D
C
HR
N
HV
P
VL
A
I
A
A
HIPSSE
IG
--
S
G
Y
FQE
T
H
PQ
--------
ELFRECS
H
YCE
LV
SSP
E
Q
I
P
QV
L
AI
A
MRK
A
V
L
-
N
R
-
G
V
S
V
V
V
LP
G
DV
ALKPA---
---
PEGATTHWYHAPQ
P
IVTPEEEE
L
RK
L
AQL
L
RY
S
SN
I
A
L
MC
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
IVHA
L
R
G
KE
HV
E
YD
N
P
YDV
GM
T
G
L
I
G
FSSGFHT
M
M
NAD
T
L
VL
L
G
T
Q
F
PY
R
A------
F
Y
P
T
D
A
KI
I
Q
IDI
N
P
A
S
I
GAHSKVD
M
A
L
VGD
IKST
L
RA
LL
PL
V
EEKTDRK
F
L
D
--
--
-
-
T
ALEDY
R
DARKGLDDLAKPS
E
----------------------------
K
A
IHPQYLAQQ
I
SH
----
FAADDAIF
T
C
DVG
TP
T
V
W
AA
RY
-
LKMNG
K
R
RL
L
G
S
F
--------
NH
G
S
M
A
N
AM
P
Q
A
L
GA
QA
T
E
P
ERQ
VV
A
MC
GDG
GFS
M
LMG
D
FL
S
VV
Q
MK
LPV
K
IV
VF
NN
SV
LG
F
V
A
-
--ME
M
KAGGYLTDGTELHD
-----------
TN
F
AR
I
A
E
A
C
G
IT
G
IR
V
EKAS
E
VDE
AL
QRAFSI
---
DG
P
VL
V
D
V
V
VA
KE
--------
E
LAI
P
P
Q
IK
fig|714962.3.peg.880
Escherichia coli IHE3034 (9-539/572)
I
A
KT
L
ESA
GV
KR
I
W
G
VT
G
DS
L
NG
L
S
D
S
L
NRM
-
G
T
I
E
W
M
ST
RHE
E
V
A
AFA
A
G
A
E
A
QLS
G
E
L
A
V
--
C
AGS
C
GPG
N
LH
L
I
N
GL
F
D
C
HR
N
HV
P
VL
A
I
A
A
HIPSSE
IG
--
S
G
Y
FQE
T
H
PQ
--------
ELFRECS
H
YCE
LV
SSP
E
Q
I
P
QV
L
AI
A
MRK
A
V
L
-
N
R
-
G
V
S
V
V
V
LP
G
DV
ALKPA---
---
PEGATTHWYHAPQ
P
VVTPEEEE
L
RK
L
AQL
L
RY
S
SN
I
A
L
MC
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
IVHA
L
R
G
KE
HV
E
YD
N
P
YDV
GM
T
G
L
I
G
FSSGFHT
M
M
NAD
T
L
VL
L
G
T
Q
F
PY
R
V------
F
Y
P
T
D
A
KI
I
Q
IDI
N
P
A
S
I
GAHSKVD
M
A
L
VGD
IKST
L
RA
LL
PL
V
EEKTERK
F
L
D
--
--
-
-
K
ALEDY
R
DARKGLDDLAKPS
E
----------------------------
K
A
IHPQYLAQQ
I
SH
----
FAADDAIF
T
C
DVG
TP
T
V
W
AA
RY
-
LKMNG
K
R
RL
L
G
S
F
--------
NH
G
S
M
A
N
AM
P
Q
A
L
GA
QA
T
E
P
ERQ
VV
A
MC
GDG
GFS
M
LMG
D
FL
S
VV
Q
MK
LPV
K
I
I
VF
NN
SV
LG
F
V
A
-
--ME
M
KAGGYLTDGTELHD
-----------
TN
F
AR
I
A
E
A
C
G
IT
G
IR
V
EKAS
E
IDE
AL
QRAFSI
---
DG
P
VL
V
D
V
V
VA
KE
--------
E
LAI
P
P
Q
IK
fig|749545.3.peg.2513
Escherichia coli MS 182-1 (9-539/572)
I
A
KT
L
ESA
GV
KR
I
W
G
VT
G
DS
L
NG
L
S
D
S
L
NRM
-
G
T
I
E
W
M
ST
RHE
E
V
A
AFA
A
G
A
E
A
QLS
G
E
L
A
V
--
C
AGS
C
GPG
N
LH
L
I
N
GL
F
D
C
HR
N
HV
P
VL
A
I
A
A
HIPSSE
IG
--
S
G
Y
FQE
T
H
PQ
--------
ELFRECS
H
YCE
LV
SSP
E
Q
I
P
QV
L
AI
A
MRK
A
V
L
-
N
R
-
G
V
S
V
V
V
LP
G
DV
ALKPA---
---
PEGATTHWYHAPQ
P
IVTPEEEE
L
RK
L
AQL
L
RY
S
SN
I
A
L
MC
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
IVHA
L
R
G
KE
HV
E
YD
N
P
YDV
GM
T
G
L
I
G
FSSGFHT
M
M
NAD
T
L
VL
L
G
T
Q
F
PY
R
A------
F
Y
P
T
D
A
KI
I
Q
IDI
N
P
A
S
I
GAHSKVD
M
A
L
VGD
IKST
L
RA
LL
PL
V
EEKTDRK
F
L
D
--
--
-
-
T
ALEDY
R
DARKGLDDLAKPS
E
----------------------------
K
A
IHPQYLAQQ
I
SH
----
FAADDAIF
T
C
DVG
TP
T
V
W
AA
RY
-
LKMNG
K
R
RL
L
G
S
F
--------
NH
G
S
M
A
N
AM
P
Q
A
L
GA
QA
T
E
P
ERQ
VV
A
MC
GDG
GFS
M
LMG
D
FL
S
VV
Q
MK
LPV
K
IV
VF
NN
SV
LG
F
V
A
-
--ME
M
KAGGYLTDGTELHD
-----------
TN
F
AR
I
A
E
A
C
G
IT
G
IR
V
EKAS
E
VDE
AL
QRAFSI
---
DG
P
VL
V
D
V
V
VA
KE
--------
E
LAI
P
P
Q
IK
fig|749532.3.peg.867
Escherichia coli MS 78-1 (9-539/572)
I
A
KT
L
ESA
GV
KR
I
W
G
VT
G
DS
L
NG
L
S
D
S
L
NRM
-
G
T
I
E
W
M
ST
RHE
E
V
A
AFA
A
G
A
E
A
QLS
G
E
L
A
V
--
C
AGS
C
GPG
N
LH
L
I
N
GL
F
D
C
HR
N
HV
P
VL
A
I
A
A
HIPSSE
IG
--
S
G
Y
FQE
T
H
PQ
--------
ELFRECS
H
YCE
LV
SSP
E
Q
I
P
QV
L
AI
A
MRK
A
V
L
-
N
R
-
G
V
S
V
V
V
LP
G
DV
ALKPA---
---
PEGATTHWYHAPQ
P
IVTPEEEE
L
RK
L
AQL
L
RY
S
SN
I
A
L
MC
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
IVHA
L
R
G
KE
HV
E
YD
N
P
YDV
GM
T
G
L
I
G
FSSGFHT
M
M
NAD
T
L
VL
L
G
T
Q
F
PY
R
A------
F
Y
P
T
D
A
KI
I
Q
IDI
N
P
A
S
I
GAHSKVD
M
A
L
VGD
IKST
L
RA
LL
PL
V
EEKTDRK
F
L
D
--
--
-
-
T
ALEDY
R
DARKGLDDLAKPS
E
----------------------------
K
A
IHPQYLAQQ
I
SH
----
FAADDAIF
T
C
DVG
TP
T
V
W
AA
RY
-
LKMNG
K
R
RL
L
G
S
F
--------
NH
G
S
M
A
N
AM
P
Q
A
L
GA
QA
T
E
P
ERQ
VV
A
MC
GDG
GFS
M
LMG
D
FL
S
VV
Q
MK
LPV
K
IV
VF
NN
SV
LG
F
V
A
-
--ME
M
KAGGYLTDGTELHD
-----------
TN
F
AR
I
A
E
A
C
G
IT
G
IR
V
EKAS
E
VDE
AL
QRAFSI
---
DG
P
VL
V
D
V
V
VA
KE
--------
E
LAI
P
P
Q
IK
fig|753642.3.peg.742
Escherichia coli NC101 (9-539/572)
I
A
KT
L
ESA
GV
KR
I
W
G
VT
G
DS
L
NG
L
S
D
S
L
NRM
-
G
T
I
E
W
M
ST
RHE
E
V
A
AFA
A
G
A
E
A
QLS
G
E
L
A
V
--
C
AGS
C
GPG
N
LH
L
I
N
GL
F
D
C
HR
N
HV
P
VL
A
I
A
A
HIPSSE
IG
--
S
G
Y
FQE
T
H
PQ
--------
ELFRECS
H
YCE
LV
SSP
E
Q
I
P
QV
L
AI
A
MRK
A
V
L
-
N
R
-
G
V
S
V
V
V
LP
G
DV
ALKPA---
---
PEGATTHWYHAPQ
P
VVTPEEEE
L
RK
L
AQL
L
RY
S
SN
I
A
L
MC
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
IVHA
L
R
G
KE
HV
E
YD
N
P
YDV
GM
T
G
L
I
G
FSSGFHT
M
M
NAD
T
L
VL
L
G
T
Q
F
PY
R
V------
F
Y
P
T
D
A
KI
I
Q
IDI
N
P
A
S
I
GAHSKVD
M
A
L
VGD
IKST
L
RA
LL
PL
V
EEKTERK
F
L
D
--
--
-
-
K
ALEDY
R
DARKGLDDLAKPS
E
----------------------------
K
A
IHPQYLAQQ
I
SH
----
FAADDAIF
T
C
DVG
TP
T
V
W
AA
RY
-
LKMNG
K
R
RL
L
G
S
F
--------
NH
G
S
M
A
N
AM
P
Q
A
L
GA
QA
T
E
P
ERQ
VV
A
MC
GDG
GFS
M
LMG
D
FL
S
VV
Q
MK
LPV
K
I
I
VF
NN
SV
LG
F
V
A
-
--ME
M
KAGGYLTDGTELHD
-----------
TN
F
AR
I
A
E
A
C
G
IT
G
IR
V
EKAS
E
IDE
AL
QRAFSI
---
DG
P
VL
V
D
V
V
VA
KE
--------
E
LAI
P
P
Q
IK
fig|585035.6.peg.893
Escherichia coli S88 (9-539/572)
I
A
KT
L
ESA
GV
KR
I
W
G
VT
G
DS
L
NG
L
S
D
S
L
NRM
-
G
T
I
E
W
M
ST
RHE
E
V
A
AFA
A
G
A
E
A
QLS
G
E
L
A
V
--
C
AGS
C
GPG
N
LH
L
I
N
GL
F
D
C
HR
N
HV
P
VL
A
I
A
A
HIPSSE
IG
--
S
G
Y
FQE
T
H
PQ
--------
ELFRECS
H
YCE
LV
SSP
E
Q
I
P
QV
L
AI
A
MRK
A
V
L
-
N
R
-
G
V
S
V
V
V
LP
G
DV
ALKPA---
---
PEGATTHWYHAPQ
P
VVTPEEEE
L
RK
L
AQL
L
RY
S
SN
I
A
L
MC
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
IVHA
L
R
G
KE
HV
E
YD
N
P
YDV
GM
T
G
L
I
G
FSSGFHT
M
M
NAD
T
L
VL
L
G
T
Q
F
PY
R
V------
F
Y
P
T
D
A
KI
I
Q
IDI
N
P
A
S
I
GAHSKVD
M
A
L
VGD
IKST
L
RA
LL
PL
V
EEKTERK
F
L
D
--
--
-
-
K
ALEDY
R
DARKGLDDLAKPS
E
----------------------------
K
A
IHPQYLAQQ
I
SH
----
FAADDAIF
T
C
DVG
TP
T
V
W
AA
RY
-
LKMNG
K
R
RL
L
G
S
F
--------
NH
G
S
M
A
N
AM
P
Q
A
L
GA
QA
T
E
P
ERQ
VV
A
MC
GDG
GFS
M
LMG
D
FL
S
VV
Q
MK
LPV
K
I
I
VF
NN
SV
LG
F
V
A
-
--ME
M
KAGGYLTDGTELHD
-----------
TN
F
AR
I
A
E
A
C
G
IT
G
IR
V
EKAS
E
IDE
AL
QRAFSI
---
DG
P
VL
V
D
V
V
VA
KE
--------
E
LAI
P
P
Q
IK
fig|431946.3.peg.834
Escherichia coli SE15 (9-539/572)
I
A
KT
L
ESA
GV
KR
I
W
G
VT
G
DS
L
NG
L
S
D
S
L
NRM
-
G
T
I
E
W
M
ST
RHE
E
V
A
AFA
A
G
A
E
A
QLS
G
E
L
A
V
--
C
AGS
C
GPG
N
LH
L
I
N
GL
F
D
C
HR
N
HV
P
VL
A
I
A
A
HIPSSE
IG
--
S
G
Y
FQE
T
H
PQ
--------
ELFRECS
H
YCE
LV
SSP
E
Q
I
P
QV
L
AI
A
MRK
A
V
L
-
N
R
-
G
V
S
V
V
V
LP
G
DV
ALKPA---
---
PEGATTHWYHAPQ
P
VVTPEEEE
L
RK
L
AQL
L
RY
S
SN
I
A
L
MC
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
IVHA
L
R
G
KE
HV
E
YD
N
P
YDV
GM
T
G
L
I
G
FSSGFHT
M
M
NAD
T
L
VL
L
G
T
Q
F
PY
R
V------
F
Y
P
T
D
A
KI
I
Q
IDI
N
P
A
S
I
GAHSKVD
M
A
L
VGD
IKST
L
RA
LL
PL
V
EEKTERK
F
L
D
--
--
-
-
K
ALEDY
R
DARKGLDDLAKPS
E
----------------------------
K
A
IHPQYLAQQ
I
SH
----
FAADDAIF
T
C
DVG
TP
T
V
W
AA
RY
-
LKMNG
K
R
RL
L
G
S
F
--------
NH
G
S
M
A
N
AM
P
Q
A
L
GA
QA
T
E
P
ERQ
VV
A
MC
GDG
GFS
M
LMG
D
FL
S
VV
Q
MK
LPV
K
I
I
VF
NN
SV
LG
F
V
A
-
--ME
M
KAGGYLTDGTELHD
-----------
TN
F
AR
I
A
E
A
C
G
IT
G
IR
V
EKAS
E
IDE
AL
QRAFSI
---
DG
P
VL
V
D
V
V
VA
KE
--------
E
LAI
P
P
Q
IK
fig|869729.3.peg.2839
Escherichia coli UM146 (9-539/572)
I
A
KT
L
ESA
GV
KR
I
W
G
VT
G
DS
L
NG
L
S
D
S
L
NRM
-
G
T
I
E
W
M
ST
RHE
E
V
A
AFA
A
G
A
E
A
QLS
G
E
L
A
V
--
C
AGS
C
GPG
N
LH
L
I
N
GL
F
D
C
HR
N
HV
P
VL
A
I
A
A
HIPSSE
IG
--
S
G
Y
FQE
T
H
PQ
--------
ELFRECS
H
YCE
LV
SSP
E
Q
I
P
QV
L
AI
A
MRK
A
V
L
-
N
R
-
G
V
S
V
V
V
LP
G
DV
ALKPA---
---
PEGATTHWYHAPQ
P
VVTPEEEE
L
RK
L
AQL
L
RY
S
SN
I
A
L
MC
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
IVHA
L
R
G
KE
HV
E
YD
N
P
YDV
GM
T
G
L
I
G
FSSGFHT
M
M
NAD
T
L
VL
L
G
T
Q
F
PY
R
V------
F
Y
P
T
D
A
KI
I
Q
IDI
N
P
A
S
I
GAHSKVD
M
A
L
VGD
IKST
L
RA
LL
PL
V
EEKTERK
F
L
D
--
--
-
-
K
ALEDY
R
DARKGLDDLAKPS
E
----------------------------
K
A
IHPQYLAQQ
I
SH
----
FAADDAIF
T
C
DVG
TP
T
V
W
AA
RY
-
LKMNG
K
R
RL
L
G
S
F
--------
NH
G
S
M
A
N
AM
P
Q
A
L
GA
QA
T
E
P
ERQ
VV
A
MC
GDG
GFS
M
LMG
D
FL
S
VV
Q
MK
LPV
K
I
I
VF
NN
SV
LG
F
V
A
-
--ME
M
KAGGYLTDGTELHD
-----------
TN
F
AR
I
A
E
A
C
G
IT
G
IR
V
EKAS
E
IDE
AL
QRAFSI
---
DG
P
VL
V
D
V
V
VA
KE
--------
E
LAI
P
P
Q
IK
fig|364106.7.peg.961
Escherichia coli UTI89 (9-539/572)
I
A
KT
L
ESA
GV
KR
I
W
G
VT
G
DS
L
NG
L
S
D
S
L
NRM
-
G
T
I
E
W
M
ST
RHE
E
V
A
AFA
A
G
A
E
A
QLS
G
E
L
A
V
--
C
AGS
C
GPG
N
LH
L
I
N
GL
F
D
C
HR
N
HV
P
VL
A
I
A
A
HIPSSE
IG
--
S
G
Y
FQE
T
H
PQ
--------
ELFRECS
H
YCE
LV
SSP
E
Q
I
P
QV
L
AI
A
MRK
A
V
L
-
N
R
-
G
V
S
V
V
V
LP
G
DV
ALKPA---
---
PEGATTHWYHAPQ
P
VVTPEEEE
L
RK
L
AQL
L
RY
S
SN
I
A
L
MC
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
IVHA
L
R
G
KE
HV
E
YD
N
P
YDV
GM
T
G
L
I
G
FSSGFHT
M
M
NAD
T
L
VL
L
G
T
Q
F
PY
R
V------
F
Y
P
T
D
A
KI
I
Q
IDI
N
P
A
S
I
GAHSKVD
M
A
L
VGD
IKST
L
RA
LL
PL
V
EEKTERK
F
L
D
--
--
-
-
K
ALEDY
R
DARKGLDDLAKPS
E
----------------------------
K
A
IHPQYLAQQ
I
SH
----
FAADDAIF
T
C
DVG
TP
T
V
W
AA
RY
-
LKMNG
K
R
RL
L
G
S
F
--------
NH
G
S
M
A
N
AM
P
Q
A
L
GA
QA
T
E
P
ERQ
VV
A
MC
GDG
GFS
M
LMG
D
FL
S
VV
Q
MK
LPV
K
I
I
VF
NN
SV
LG
F
V
A
-
--ME
M
KAGGYLTDGTELHD
-----------
TN
F
AR
I
A
E
A
C
G
IT
G
IR
V
EKAS
E
IDE
AL
QRAFSI
---
DG
P
VL
V
D
V
V
VA
KE
--------
E
LAI
P
P
Q
IK
fig|364106.8.peg.960
Escherichia coli UTI89 (9-539/572)
I
A
KT
L
ESA
GV
KR
I
W
G
VT
G
DS
L
NG
L
S
D
S
L
NRM
-
G
T
I
E
W
M
ST
RHE
E
V
A
AFA
A
G
A
E
A
QLS
G
E
L
A
V
--
C
AGS
C
GPG
N
LH
L
I
N
GL
F
D
C
HR
N
HV
P
VL
A
I
A
A
HIPSSE
IG
--
S
G
Y
FQE
T
H
PQ
--------
ELFRECS
H
YCE
LV
SSP
E
Q
I
P
QV
L
AI
A
MRK
A
V
L
-
N
R
-
G
V
S
V
V
V
LP
G
DV
ALKPA---
---
PEGATTHWYHAPQ
P
VVTPEEEE
L
RK
L
AQL
L
RY
S
SN
I
A
L
MC
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
IVHA
L
R
G
KE
HV
E
YD
N
P
YDV
GM
T
G
L
I
G
FSSGFHT
M
M
NAD
T
L
VL
L
G
T
Q
F
PY
R
V------
F
Y
P
T
D
A
KI
I
Q
IDI
N
P
A
S
I
GAHSKVD
M
A
L
VGD
IKST
L
RA
LL
PL
V
EEKTERK
F
L
D
--
--
-
-
K
ALEDY
R
DARKGLDDLAKPS
E
----------------------------
K
A
IHPQYLAQQ
I
SH
----
FAADDAIF
T
C
DVG
TP
T
V
W
AA
RY
-
LKMNG
K
R
RL
L
G
S
F
--------
NH
G
S
M
A
N
AM
P
Q
A
L
GA
QA
T
E
P
ERQ
VV
A
MC
GDG
GFS
M
LMG
D
FL
S
VV
Q
MK
LPV
K
I
I
VF
NN
SV
LG
F
V
A
-
--ME
M
KAGGYLTDGTELHD
-----------
TN
F
AR
I
A
E
A
C
G
IT
G
IR
V
EKAS
E
IDE
AL
QRAFSI
---
DG
P
VL
V
D
V
V
VA
KE
--------
E
LAI
P
P
Q
IK
fig|562.376.peg.4731
Escherichia coli WV_060327 (9-539/572)
I
A
KT
L
ESA
GV
KR
I
W
G
VT
G
DS
L
NG
L
S
D
S
L
NRM
-
G
T
I
E
W
M
ST
RHE
E
V
A
AFA
A
G
A
E
A
QLS
G
E
L
A
V
--
C
AGS
C
GPG
N
LH
L
I
N
GL
F
D
C
HR
N
HV
P
VL
A
I
A
A
HIPSSE
IG
--
S
G
Y
FQE
T
H
PQ
--------
ELFRECS
H
YCE
LV
SSP
E
Q
I
P
QV
L
AI
A
MRK
A
V
L
-
N
R
-
G
V
S
V
V
V
LP
G
DV
ALKPA---
---
PEGATTHWYHAPQ
P
VVTPEEEE
L
RK
L
AQL
L
RY
S
SN
I
A
L
MC
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
IVHA
L
R
G
KE
HV
E
YD
N
P
YDV
GM
T
G
L
I
G
FSSGFHT
M
M
NAD
T
L
VL
L
G
T
Q
F
PY
R
V------
F
Y
P
T
D
A
KI
I
Q
IDI
N
P
A
S
I
GAHSKVD
M
A
L
VGD
IKST
L
RA
LL
PL
V
EEKTERK
F
L
D
--
--
-
-
K
ALEDY
R
DARKGLDDLAKPS
E
----------------------------
K
A
IHPQYLAQQ
I
SH
----
FAADDAIF
T
C
DVG
TP
T
V
W
AA
RY
-
LKMNG
K
R
RL
L
G
S
F
--------
NH
G
S
M
A
N
AM
P
Q
A
L
GA
QA
T
E
P
ERQ
VV
A
MC
GDG
GFS
M
LMG
D
FL
S
VV
Q
MK
LPV
K
I
I
VF
NN
SV
LG
F
V
A
-
--ME
M
KAGGYLTDGTELHD
-----------
TN
F
AR
I
A
E
A
C
G
IT
G
IR
V
EKAS
E
IDE
AL
QRAFSI
---
DG
P
VL
V
D
V
V
VA
KE
--------
E
LAI
P
P
Q
IK
fig|749531.3.peg.1672
Escherichia coli MS 69-1 (9-539/572)
I
A
KT
L
ESA
GV
KR
I
W
G
VT
G
DS
L
NG
L
S
D
S
L
NRM
-
G
T
I
E
W
M
ST
RHE
E
V
A
AFA
A
G
A
E
A
QLS
G
E
L
A
V
--
C
AGS
C
GPG
N
LH
L
I
N
GL
F
D
C
HR
N
HV
P
VL
A
I
A
A
HIPSSE
IG
--
S
G
Y
FQE
T
H
PQ
--------
ELFRECS
H
YCE
LV
SSP
E
Q
I
P
QV
L
AI
A
MRK
A
V
L
-
N
R
-
G
V
S
V
V
V
LP
G
DV
ALKPA---
---
PEGATSHWYHAPQ
P
VVTPEEEE
L
RK
L
AQL
L
RY
S
SN
I
A
L
MC
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
IVHA
L
R
G
KE
HV
E
YD
N
P
YDV
GM
T
G
L
I
G
FSSGFHT
M
M
NAD
T
L
VL
L
G
T
Q
F
PY
R
A------
F
Y
P
T
D
A
KI
I
Q
IDI
N
P
A
S
I
GAHSKVD
M
A
L
VGD
IKST
L
RA
LL
PL
V
EEKNDRK
F
L
D
--
--
-
-
K
ALEDY
R
DARKGLDDLAKPS
E
----------------------------
K
A
IHPQYLAQQ
I
SH
----
FAADDAIF
T
C
DVG
TP
T
V
W
AA
RY
-
LKMNG
K
R
RL
L
G
S
F
--------
NH
G
S
M
A
N
AM
P
Q
A
L
GA
QA
T
E
P
ERQ
VV
A
MC
GDG
GFS
M
LMG
D
FL
S
VV
Q
MK
LPV
K
I
I
VF
NN
SV
LG
F
V
A
-
--ME
M
KAGGYLTDGTELHD
-----------
TN
F
AR
I
A
E
A
C
G
IT
G
IR
V
EKAS
E
VDE
AL
QRAFSI
---
DG
P
VL
V
D
V
V
VA
KE
--------
E
LAI
P
P
Q
IK
fig|155864.8.peg.979
Escherichia coli O157:H7 EDL933 (9-539/572)
I
A
KT
L
ESA
GV
KR
I
W
G
VT
G
DS
L
NG
L
S
D
S
L
NRM
-
G
T
I
X
W
M
ST
RHE
E
V
A
AFA
A
G
A
E
A
QLS
G
E
L
A
V
--
C
AGS
C
GPG
N
LH
L
I
N
GL
F
D
C
HR
N
HV
P
VL
A
I
A
A
HIPSSE
IG
--
S
G
Y
FQE
T
H
PQ
--------
ELFRECS
H
YCE
LV
SSP
E
Q
I
P
QV
L
AI
A
MRK
A
V
L
-
N
R
-
G
V
S
V
V
V
LP
G
DV
ALKPA---
---
PEGATTHWYHAPQ
P
VVTPEEEE
L
RK
L
AQL
L
RY
S
SN
I
A
L
MC
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
IVHA
L
R
G
KE
HV
E
YD
N
P
YDV
GM
T
G
L
I
G
FSSGFHT
M
M
NAD
T
L
VL
L
G
T
Q
F
PY
R
A------
F
Y
P
T
D
A
KI
I
Q
IDI
N
P
A
S
I
GAHSKVD
M
A
L
VGD
IKST
L
RA
LL
PL
V
EEKADRK
F
L
D
--
--
-
-
K
ALEDY
R
DARKGLDDLAKPS
E
----------------------------
K
A
IHPQYLAQQ
I
SH
----
FAADDAIF
T
C
DVG
TP
T
V
W
AA
RY
-
LKMNG
K
R
RL
L
G
S
F
--------
NH
G
S
M
A
N
AM
P
Q
A
L
GA
QA
T
E
P
ERQ
VV
A
MC
GDG
GFS
M
LMG
D
FL
S
VV
Q
MK
LPV
K
I
I
VF
NN
SV
LG
F
V
A
-
--ME
M
KAGGYLTDGTELHD
-----------
TN
F
AR
I
A
E
A
C
G
IT
G
IR
V
EKAS
E
IDE
AL
QRAFSI
---
DG
P
VL
V
D
V
V
VA
KE
--------
E
LAI
P
P
Q
IK
fig|550676.3.peg.339
Escherichia coli B185 (9-539/572)
I
A
KT
L
ESA
GV
KR
I
W
G
VT
G
DS
L
NG
L
S
D
S
L
NRM
-
G
T
I
E
W
M
ST
RHE
E
V
A
AFA
A
G
A
E
A
QLS
G
E
L
A
V
--
C
AGS
C
GPG
N
LH
L
I
N
GL
F
D
C
HR
N
HV
P
VL
A
I
A
A
HIPSSE
IG
--
S
G
Y
FQE
T
H
PQ
--------
ELFRECS
H
YCE
LV
SSP
E
Q
I
P
QV
L
AI
A
MRK
A
V
L
-
N
R
-
G
V
S
V
V
V
LP
G
DV
ALKPA---
---
PEGATTHWYHAPQ
P
VVTPEEEE
L
RK
L
AQL
L
RY
S
SN
I
A
L
MC
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
IVHA
L
R
G
KE
HV
E
YD
N
P
YDV
GM
T
G
L
I
G
FSSGFHT
M
M
NAD
T
L
VL
L
G
T
Q
F
PY
R
A------
F
Y
P
T
D
A
KI
I
Q
IDI
N
P
A
S
I
GAHSKVD
M
A
L
VGD
IKST
L
RA
LL
PL
V
EEKADRK
F
L
D
--
--
-
-
K
ALEDY
R
DARKGLDDLAKPS
E
----------------------------
K
A
IHPQYLAQQ
I
SH
----
FAADDAIF
T
C
DVG
TP
T
V
W
AA
RY
-
LKMNG
K
R
RL
L
G
S
F
--------
NH
G
S
M
A
N
AM
P
Q
A
L
GA
QA
T
E
P
ERQ
VV
A
MC
GDG
GFS
M
LMG
D
FL
S
VV
Q
MK
LPV
K
I
I
VS
NN
SV
LG
F
V
A
-
--ME
M
KAGGYLTDGTELHD
-----------
TN
F
AR
I
A
E
A
C
G
IT
G
IR
V
EKAS
E
VDE
AL
QRAFSI
---
DG
P
VL
V
D
V
V
VA
KE
--------
E
LAI
P
P
Q
IK
fig|656444.3.peg.1482
Escherichia coli TA280 (9-539/572)
I
A
KT
L
ESA
GV
KR
I
W
G
VT
G
DS
L
NG
L
S
D
S
L
NRM
-
G
T
I
E
W
M
ST
RHE
E
V
A
AFA
A
G
A
E
A
QLS
G
E
L
A
V
--
C
AGS
C
GPG
N
LH
L
I
N
GL
F
D
C
HR
N
HV
P
VL
A
I
A
A
HIPSSE
IG
--
S
G
Y
FQE
T
H
PQ
--------
ELFRECS
H
YCE
LV
SSP
E
Q
I
P
QV
L
AI
A
MRK
A
V
L
-
N
R
-
G
V
S
V
V
V
LP
G
DV
ALKPA---
---
PEGATTHWYHAPQ
P
VVTPEEEE
L
RK
L
AQL
L
RY
S
SN
I
A
L
MC
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
IVHA
L
R
G
KE
HV
E
YD
N
P
YDV
GM
T
G
L
I
G
FSSGFHS
M
M
NAD
T
L
VL
L
G
T
Q
F
PY
R
A------
F
Y
P
T
D
A
KI
I
Q
IDI
N
P
A
S
I
GAHSKVD
M
A
L
VGD
IKST
L
RA
L
F
PL
V
EEKADRK
F
L
D
--
--
-
-
K
ALEDY
R
DARKGLDDLAKPS
E
----------------------------
K
A
IHPQYLAQQ
I
SH
----
FAADDAIF
T
C
DVG
TP
T
V
W
AA
RY
-
LKMNG
K
R
RL
L
G
S
F
--------
NH
G
S
M
A
N
AM
P
Q
A
L
GA
QA
T
E
P
ERQ
VV
A
MC
GDG
GFS
M
LMG
D
FL
S
VV
Q
MK
LPV
K
I
I
VF
NN
SV
LG
F
V
A
-
--ME
M
KAGGYLTDGTELHD
-----------
TN
F
AR
I
A
E
A
C
G
IT
G
IR
V
EKAS
E
IDE
AL
QRAFSI
---
DG
P
VL
V
D
V
V
VA
KE
--------
E
LAI
P
P
Q
IK
fig|550677.3.peg.1962
Escherichia coli B354 (13-563/564)
IIV
EA
L
KQN
D
I
DT
I
Y
G
VV
G
IP
V
TD
M
A
R
H
A
QAE
-
G
-
I
R
Y
I
GF
RHEQ
S
A
GYA
A
A
A
S
G
FLT
Q
K
P
G
I
--
C
LTV
S
A
PG
F
L
N
G
L
T
A
LA
N
A
TV
N
GF
P
M
I
M
ISG
SSDRAI
VDLQ
Q
G
D
YE
E
L
D
QM
--------
NAAKPYA
K
AAF
R
V
NQP
Q
DL
G
IA
L
AR
A
IRV
S
V
S
-
GRPG
G
V
Y
L
DLP
A
N
V
LAATMEKD
---
EALTTIVKVENPS
P
ALLPCPKS
V
TS
A
ISL
L
AK
A
ER
P
L
V
IL
G
K
G
AAY
S
Q
A
DEQ
L
R
E
FIESAQI
P
FLPM
S
M
AK
G
IL
E
DT
HP
---
--
-
-
L
S
A
ATARSFA
L
A
NAD
V
V
ML
VG
A
R
L
NW
L
LAHGKKG
W
A
A
-
D
T
QF
I
Q
L
DI
E
P
Q
EI
DSNRPIA
V
P
V
VGD
IASS
M
QD
M
L
AE
L
KQNTFTT
PL
V
--
--
W
R
D
ILNIH
K
QQNAQKMHEKLST
D
----------------------------
T
-
-QPLNYFNA
L
SA
VRDV
LRENQDIY
L
V
NE
G
AN
T
L
D
N
A
RN
I
IDMYK
PR
RR
L
D
C
G
--------
TW
G
V
MG
I
G
MG
Y
AIGA
SV
T
S
G
S-P
VV
A
IE
GD
S
AFG
F
SGM
E
IE
T
IC
R
YN
LPV
T
IV
IF
NN
G-
-
G
I
Y
R
G
DGVD
L
SGAGAPSPTDLLHH
-----------
AR
Y
DK
L
M
D
A
F
R
GV
G
YN
V
TTTD
E
LRH
AL
TTGIQS
---
RK
P
TI
I
N
V
V
ID
PA
AGTESGHIT
KLN
P
K
Q
VA
G
fig|439855.10.peg.2685
Escherichia coli SMS-3-5 (13-563/564)
IIV
EA
L
KQN
NI
DT
I
Y
G
VV
G
IP
V
TD
M
A
R
H
A
QAE
-
G
-
I
R
Y
I
GF
RHEQ
S
A
GYA
A
A
A
S
G
FLT
Q
K
P
G
I
--
C
LTV
S
A
PG
F
L
N
G
L
T
A
LA
N
A
TV
N
GF
P
M
I
M
ISG
SSDRAI
VDLQ
Q
G
D
YE
E
L
D
QM
--------
NAAKPYA
K
AAF
R
V
NQP
Q
DL
G
IA
L
AR
A
IRV
S
V
S
-
GRPG
G
V
Y
L
DLP
A
N
V
LAATMEKD
---
EALTTIVKVENPS
P
ALLPCPKS
V
AS
A
ISL
L
AK
A
ER
P
L
V
IL
G
K
G
AAY
S
Q
A
DEQ
L
R
E
FIESAQI
P
FLPM
S
M
AK
G
IL
E
DT
HP
---
--
-
-
L
S
A
ATARSFA
L
A
NAD
V
V
ML
VG
A
R
L
NW
L
LAHGKKG
W
A
A
-
D
T
QF
I
Q
L
DI
E
P
Q
EI
DSNRPIA
V
P
V
VGD
IASS
M
QG
M
L
AE
L
KQNTFTT
PL
V
--
--
W
R
D
ILNIH
K
QQNAQKMHEKLST
D
----------------------------
T
-
-QPLNYFNA
L
SA
VRDV
LRENQDIY
L
V
NE
G
AN
T
L
D
N
A
RN
I
IDMYK
PR
RR
L
D
C
G
--------
TW
G
V
MG
I
G
MG
Y
AIGA
SV
T
S
G
S-P
VV
A
IE
GD
S
AFG
F
SGM
E
IE
T
IC
R
YN
LPV
T
IV
IF
NN
G-
-
G
I
Y
R
G
DGVD
L
SGAGAPSPTDLLHH
-----------
AR
Y
DK
L
M
D
A
F
R
GV
G
YN
V
TTTD
E
LRH
AL
TTGIQS
---
RK
P
TI
I
N
V
V
ID
PA
AGTESGHIT
KLN
P
K
Q
VA
G
fig|656379.3.peg.2958
Escherichia coli FVEC1302 (13-563/564)
IIV
EA
L
KQN
D
I
DT
I
Y
G
VV
G
IP
V
TD
M
A
R
H
A
QAE
-
G
-
I
R
Y
I
GF
RHEQ
S
A
GYA
A
A
A
S
G
FLT
Q
K
P
G
I
--
C
LTV
S
A
PG
F
L
N
G
L
T
A
LA
N
A
TV
N
GF
P
M
I
M
ISG
SSDRAI
VDLQ
Q
G
D
YE
E
L
D
QM
--------
NAAKPYA
K
AAF
R
V
NQP
Q
DL
G
IA
L
AR
A
IRV
S
V
S
-
GRPG
G
V
Y
L
DLP
A
N
V
LAATMEKD
---
EALTTIVKVENPS
P
ALLPCPKS
V
AS
A
ISL
L
AK
A
ER
P
L
V
IL
G
K
G
AAY
S
Q
A
DEQ
L
R
E
FIESAQI
P
FLPM
S
M
AK
G
IL
E
DT
HP
---
--
-
-
L
S
A
ATARSFA
L
A
NAD
V
V
ML
VG
A
R
L
NW
L
LAHGKKG
W
A
A
-
D
T
QF
I
Q
L
DI
E
P
Q
EI
DSNRPIA
V
P
V
VGD
IASS
M
QG
M
L
AE
L
KQNTFTT
PL
V
--
--
W
R
D
ILNIH
K
QQNAQKMHEKLST
D
----------------------------
T
-
-QPLNYFNA
L
SA
VRDV
LRENQDIY
L
V
NE
G
AN
T
L
D
N
A
RN
I
IDMYK
PR
RR
L
D
C
G
--------
TW
G
V
MG
I
G
MG
Y
AIGA
SV
T
S
G
S-P
VV
A
IE
GD
S
AFG
F
SGM
E
IE
T
IC
R
YN
LPV
T
IV
IF
NN
G-
-
G
I
Y
R
G
DGVD
L
SGAGAPSPTDLLHH
-----------
AR
Y
DK
L
M
D
A
F
R
GV
G
YN
V
TTTD
E
LRH
AL
TTGIQS
---
RK
P
TI
I
N
V
V
ID
PA
AGTESGHIT
KLN
P
K
Q
VA
G
fig|656380.3.peg.2461
Escherichia coli FVEC1412 (13-563/564)
IIV
EA
L
KQN
D
I
DT
I
Y
G
VV
G
IP
V
TD
M
A
R
H
A
QAE
-
G
-
I
R
Y
I
GF
RHEQ
S
A
GYA
A
A
A
S
G
FLT
Q
K
P
G
I
--
C
LTV
S
A
PG
F
L
N
G
L
T
A
LA
N
A
TV
N
GF
P
M
I
M
ISG
SSDRAI
VDLQ
Q
G
D
YE
E
L
D
QM
--------
NAAKPYA
K
AAF
R
V
NQP
Q
DL
G
IA
L
AR
A
IRV
S
V
S
-
GRPG
G
V
Y
L
DLP
A
N
V
LAATMEKD
---
EALTTIVKVENPS
P
ALLPCPKS
V
AS
A
ISL
L
AK
A
ER
P
L
V
IL
G
K
G
AAY
S
Q
A
DEQ
L
R
E
FIESAQI
P
FLPM
S
M
AK
G
IL
E
DT
HP
---
--
-
-
L
S
A
ATARSFA
L
A
NAD
V
V
ML
VG
A
R
L
NW
L
LAHGKKG
W
A
A
-
D
T
QF
I
Q
L
DI
E
P
Q
EI
DSNRPIA
V
P
V
VGD
IASS
M
QG
M
L
AE
L
KQNTFTT
PL
V
--
--
W
R
D
ILNIH
K
QQNAQKMHEKLST
D
----------------------------
T
-
-QPLNYFNA
L
SA
VRDV
LRENQDIY
L
V
NE
G
AN
T
L
D
N
A
RN
I
IDMYK
PR
RR
L
D
C
G
--------
TW
G
V
MG
I
G
MG
Y
AIGA
SV
T
S
G
S-P
VV
A
IE
GD
S
AFG
F
SGM
E
IE
T
IC
R
YN
LPV
T
IV
IF
NN
G-
-
G
I
Y
R
G
DGVD
L
SGAGAPSPTDLLHH
-----------
AR
Y
DK
L
M
D
A
F
R
GV
G
YN
V
TTTD
E
LRH
AL
TTGIQS
---
RK
P
TI
I
N
V
V
ID
PA
AGTESGHIT
KLN
P
K
Q
VA
G
fig|749549.3.peg.5039
Escherichia coli MS 198-1 (13-563/564)
IIV
EA
L
KQN
D
I
DT
I
Y
G
VV
G
IP
V
TD
M
A
R
H
A
QAE
-
G
-
I
R
Y
I
GF
RHEQ
S
A
GYA
A
A
A
S
G
FLT
Q
K
P
G
I
--
C
LTV
S
A
PG
F
L
N
G
L
T
A
LA
N
A
TV
N
GF
P
M
I
M
ISG
SSDRAI
VDLQ
Q
G
D
YE
E
L
D
QM
--------
NAAKPYA
K
AAF
R
V
NQP
Q
DL
G
IA
L
AR
A
IRV
S
V
S
-
GRPG
G
V
Y
L
DLP
A
N
V
LAATMEKD
---
EALTTIVKVENPS
P
ALLPCPKS
V
AS
A
ISL
L
AK
A
ER
P
L
V
IL
G
K
G
AAY
S
Q
A
DEQ
L
R
E
FIESAQI
P
FLPM
S
M
AK
G
IL
E
DT
HP
---
--
-
-
L
S
A
ATARSFA
L
A
NAD
V
V
ML
VG
A
R
L
NW
L
LAHGKKG
W
A
A
-
D
T
QF
I
Q
L
DI
E
P
Q
EI
DSNRPIA
V
P
V
VGD
IASS
M
QG
M
L
AE
L
KQNTFTT
PL
V
--
--
W
R
D
ILNIH
K
QQNAQKMHEKLST
D
----------------------------
T
-
-QPLNYFNA
L
SA
VRDV
LRENQDIY
L
V
NE
G
AN
T
L
D
N
A
RN
I
IDMYK
PR
RR
L
D
C
G
--------
TW
G
V
MG
I
G
MG
Y
AIGA
SV
T
S
G
S-P
VV
A
IE
GD
S
AFG
F
SGM
E
IE
T
IC
R
YN
LPV
T
IV
IF
NN
G-
-
G
I
Y
R
G
DGVD
L
SGAGAPSPTDLLHH
-----------
AR
Y
DK
L
M
D
A
F
R
GV
G
YN
V
TTTD
E
LRH
AL
TTGIQS
---
RK
P
TI
I
N
V
V
ID
PA
AGTESGHIT
KLN
P
K
Q
VA
G
fig|585056.7.peg.2884
Escherichia coli UMN026 (13-563/564)
IIV
EA
L
KQN
D
I
DT
I
Y
G
VV
G
IP
V
TD
M
A
R
H
A
QAE
-
G
-
I
R
Y
I
GF
RHEQ
S
A
GYA
A
A
A
S
G
FLT
Q
K
P
G
I
--
C
LTV
S
A
PG
F
L
N
G
L
T
A
LA
N
A
TV
N
GF
P
M
I
M
ISG
SSDRAI
VDLQ
Q
G
D
YE
E
L
D
QM
--------
NAAKPYA
K
AAF
R
V
NQP
Q
DL
G
IA
L
AR
A
IRV
S
V
S
-
GRPG
G
V
Y
L
DLP
A
N
V
LAATMEKD
---
EALTTIVKVENPS
P
ALLPCPKS
V
AS
A
ISL
L
AK
A
ER
P
L
V
IL
G
K
G
AAY
S
Q
A
DEQ
L
R
E
FIESAQI
P
FLPM
S
M
AK
G
IL
E
DT
HP
---
--
-
-
L
S
A
ATARSFA
L
A
NAD
V
V
ML
VG
A
R
L
NW
L
LAHGKKG
W
A
A
-
D
T
QF
I
Q
L
DI
E
P
Q
EI
DSNRPIA
V
P
V
VGD
IASS
M
QG
M
L
AE
L
KQNTFTT
PL
V
--
--
W
R
D
ILNIH
K
QQNAQKMHEKLST
D
----------------------------
T
-
-QPLNYFNA
L
SA
VRDV
LRENQDIY
L
V
NE
G
AN
T
L
D
N
A
RN
I
IDMYK
PR
RR
L
D
C
G
--------
TW
G
V
MG
I
G
MG
Y
AIGA
SV
T
S
G
S-P
VV
A
IE
GD
S
AFG
F
SGM
E
IE
T
IC
R
YN
LPV
T
IV
IF
NN
G-
-
G
I
Y
R
G
DGVD
L
SGAGAPSPTDLLHH
-----------
AR
Y
DK
L
M
D
A
F
R
GV
G
YN
V
TTTD
E
LRH
AL
TTGIQS
---
RK
P
TI
I
N
V
V
ID
PA
AGTESGHIT
KLN
P
K
Q
VA
G
fig|749531.3.peg.3288
Escherichia coli MS 69-1 (13-563/564)
IIV
EA
L
KQN
D
I
DT
I
Y
G
VV
G
IP
V
TD
M
A
R
H
A
QAE
-
G
-
I
R
Y
I
GF
RHEQ
S
A
GYA
A
A
A
S
G
FLT
Q
K
P
G
I
--
C
LTV
S
A
PG
F
L
N
G
L
T
A
LA
N
A
TV
N
GF
P
M
I
M
ISG
SSDRAI
VDLQ
Q
G
D
YE
E
L
D
QM
--------
NAAKPYA
K
AAF
R
V
NQP
Q
DL
G
IA
L
AR
A
IRV
S
V
S
-
GRPG
G
V
Y
L
DLP
A
N
V
LAATMEKD
---
EALTTIVKVENPS
P
ALLPCPKS
V
TS
A
ISL
L
AK
A
ER
P
L
V
IL
G
K
G
AAY
S
Q
A
DEQ
L
R
E
FIESAQI
P
FLPM
S
M
AK
G
IL
E
DT
HP
---
--
-
-
L
S
A
ATARSFA
L
A
NAD
V
V
ML
VG
A
R
L
NW
L
LAHGKKG
W
A
A
-
D
T
QF
I
Q
L
DI
E
P
Q
EI
DSNRPIA
V
P
V
VGD
IASS
M
QG
M
L
AE
L
KQNTFTT
PL
V
--
--
W
R
D
ILNIH
K
QQNAQKMHEKLST
D
----------------------------
T
-
-QPLNYFNA
L
SA
VRDV
LRENQDIY
L
V
NE
G
AN
T
L
D
N
A
RN
I
IDMYK
PR
RR
L
D
C
G
--------
TW
G
V
MG
I
G
MG
Y
AIGA
SV
T
S
G
S-P
VV
A
IE
GD
S
AFG
F
SGM
E
IE
T
IC
R
YN
LPV
T
IV
IF
NN
G-
-
G
I
Y
R
G
DGVD
L
SGAGAPSPTDLLHH
-----------
AR
Y
DK
L
M
D
A
F
R
GV
G
YN
V
TTTD
E
LRH
AL
TTGIQS
---
RK
P
TI
I
N
V
V
ID
PA
AGTESGHIT
KLN
P
K
Q
VA
G
fig|656444.3.peg.3372
Escherichia coli TA280 (13-563/564)
IIV
EA
L
KQN
D
I
DT
I
Y
G
VV
G
IP
V
TD
M
A
R
H
A
QAE
-
G
-
I
R
Y
I
GF
RHEQ
S
A
GYA
A
A
A
S
G
FLT
Q
K
P
G
I
--
C
LTV
S
A
PG
F
L
N
G
L
T
A
LA
N
A
TV
N
GF
P
M
I
M
ISG
SSDRAI
VDLQ
Q
G
D
YE
E
L
D
QM
--------
NAAKPYA
K
AAF
R
V
NQP
Q
DL
G
IA
L
AR
A
IRV
S
V
S
-
GRPG
G
V
Y
L
DLP
A
N
V
LAATMEKD
---
EALTTIVKVENPS
P
ALLPCPKS
V
TS
A
ISL
L
AK
A
ER
P
L
I
IL
G
K
G
AAY
S
Q
A
DEQ
L
R
E
FIESAQI
P
FLPM
S
M
AK
G
IL
E
DT
HP
---
--
-
-
L
S
A
ATARSFA
L
A
NAD
V
V
ML
VG
A
R
L
NW
L
LAHGKKG
W
A
A
-
D
T
QF
I
Q
L
DI
E
P
Q
EI
DSNRPIA
V
P
V
VGD
IASS
M
QG
M
L
AE
L
KQNTFTT
PL
V
--
--
W
R
D
ILNIH
K
QQNAQKMHEKLST
D
----------------------------
T
-
-QPLNYFNA
L
SA
VRDV
LRENQDIY
L
V
NE
G
AN
T
L
D
N
A
RN
I
IDMYK
PR
RR
L
D
C
G
--------
TW
G
V
MG
I
G
MG
Y
AIGA
SV
T
S
G
S-P
VV
A
IE
GD
S
AFG
F
SGM
E
IE
T
IC
R
YN
LPV
T
IV
IF
NN
G-
-
G
I
Y
R
G
DGVD
L
SGAGAPSPTDLLHH
-----------
AR
Y
DK
L
M
D
A
F
R
GV
G
YN
V
TTTD
E
LRH
AL
TTGIQS
---
RK
P
TI
I
N
V
V
ID
PA
AGTESGHIT
KLN
P
K
Q
VA
G
fig|656393.3.peg.3397
Escherichia coli H299 (13-563/564)
IIV
EA
L
KQN
G
I
DT
I
Y
G
VV
G
IP
V
TD
M
A
R
H
A
QAE
-
G
-
I
R
Y
I
GF
RHEQ
S
A
GYA
A
A
A
S
G
FLT
Q
K
P
G
I
--
C
LTV
S
A
PG
F
L
N
G
L
T
A
LA
N
A
TV
N
GF
P
M
I
M
ISG
SSDRAI
VDLQ
Q
G
D
YE
E
L
D
QM
--------
NAAKPYA
K
AAF
R
V
NQP
Q
DL
G
IA
L
AR
A
IRV
S
V
S
-
GRPG
G
V
Y
L
DLP
A
N
V
LAATMEKD
---
EALTTIVKVENPS
P
ALLPCPKS
V
AS
A
ISL
L
AK
A
ER
P
L
I
IL
G
K
G
AAY
S
Q
A
DEQ
L
R
E
FIESAQI
P
FLPM
S
M
AK
G
IL
E
DT
HP
---
--
-
-
L
S
A
AAARSFA
L
A
NAD
V
V
ML
VG
A
R
L
NW
L
LAHGKKG
W
A
A
-
D
T
QF
I
Q
L
DI
E
P
Q
EI
DSNRPIA
V
P
V
VGD
IASS
M
QG
M
L
AE
L
KQNTFTT
PL
V
--
--
W
R
D
ILNIH
K
QQNAQKMHEKLST
D
----------------------------
T
-
-QPLNYFNA
L
SA
VRDV
LRENQDIY
L
V
NE
G
AN
T
L
D
N
A
RN
I
IDMYK
PR
RR
L
D
C
G
--------
TW
G
V
MG
I
G
MG
Y
AIGA
SV
T
S
G
S-P
VV
A
IE
GD
S
AFG
F
SGM
E
IE
T
IC
R
YN
LPV
T
IV
IF
NN
G-
-
G
I
Y
R
G
DGVD
L
SGAGAPSPTDLLHH
-----------
AR
Y
DK
L
M
D
A
F
R
GV
G
YN
V
TTTD
E
LRH
AL
TTGIQS
---
RK
P
TI
I
N
V
V
ID
PA
AGTESGHIT
KLN
P
K
Q
VA
G
fig|670888.3.peg.3910
Escherichia coli 1827-70 (13-563/564)
IIV
EA
L
KQN
NI
DT
I
Y
G
VV
G
IP
V
TD
M
A
R
H
A
QAE
-
G
-
I
R
Y
I
GF
RHEQ
S
A
GYA
A
A
A
S
G
FLT
Q
K
P
G
I
--
C
LTV
S
A
PG
F
L
N
G
L
T
A
LA
N
A
TV
N
GF
P
M
I
M
ISG
SSDRAI
VDLQ
Q
G
D
YE
E
L
D
QM
--------
NAAKPYA
K
AAF
R
V
NQP
Q
DL
G
IA
L
AR
A
IRV
S
V
S
-
GRPG
G
V
Y
L
DLP
A
N
V
LAATMEKD
---
EALTTIVKVENPS
P
ALLPCPKS
V
TS
A
ISL
L
AK
A
ER
P
L
I
IL
G
K
G
AAY
S
Q
A
DEQ
L
R
E
FIESTQI
P
FLPM
S
M
AK
G
IL
E
DT
HP
---
--
-
-
L
S
A
AAARSFA
L
A
NAD
V
V
ML
VG
A
R
L
NW
L
LAHGKKG
W
A
A
-
D
T
QF
I
Q
L
DI
E
P
Q
EI
DSNRPIA
V
P
V
VGD
IASS
M
QG
M
L
AE
L
KQNTFTT
PL
V
--
--
W
R
D
ILNIH
K
QQNAQKMHEKLST
D
----------------------------
T
-
-QPLNYFNA
L
SA
VRDV
LRENQDIY
L
V
NE
G
AN
T
L
D
N
A
RN
I
IDMYK
PR
RR
L
D
C
G
--------
TW
G
V
MG
I
G
MG
Y
AIGA
SV
T
S
G
S-P
VV
A
IE
GD
S
AFG
F
SGM
E
IE
T
IC
R
YN
LPV
T
IV
IF
NN
G-
-
G
I
Y
R
G
DGVD
L
SGAGAPSPTDLMHH
-----------
AR
Y
DK
L
M
D
A
F
R
GV
G
YN
V
TTTD
E
LRH
AL
TTGIQS
---
RK
P
TI
I
N
V
V
ID
PA
AGTESGHIT
QLN
P
K
Q
VA
G
fig|344610.3.peg.321
Escherichia coli 53638 (13-563/564)
IIV
EA
L
KQN
NI
DT
I
Y
G
VV
G
IP
V
TD
M
A
R
H
A
QAE
-
G
-
I
R
Y
I
GF
RHEQ
S
A
GYA
A
A
A
S
G
FLT
Q
K
P
G
I
--
C
LTV
S
A
PG
F
L
N
G
L
T
A
LA
N
A
TV
N
GF
P
M
I
M
ISG
SSDRAI
VDLQ
Q
G
D
YE
E
L
D
QM
--------
NAAKPYA
K
AAF
R
V
NQP
Q
DL
G
IA
L
AR
A
IRV
S
V
S
-
GRPG
G
V
Y
L
DLP
A
N
V
LAATMEKD
---
EALTTIVKVENPS
P
ALLPCPKS
V
TS
A
ISL
L
AK
A
ER
P
L
I
IL
G
K
G
AAY
S
Q
A
DEQ
L
R
E
FIESTQI
P
FLPM
S
M
AK
G
IL
E
DT
HP
---
--
-
-
L
S
A
AAARSFA
L
A
NAD
V
V
ML
VG
A
R
L
NW
L
LAHGKKG
W
A
A
-
D
T
QF
I
Q
L
DI
E
P
Q
EI
DSNRPIA
V
P
V
VGD
IASS
M
QG
M
L
AE
L
KQNTFTT
PL
V
--
--
W
R
D
ILNIH
K
QQNAQKMHEKLST
D
----------------------------
T
-
-QPLNYFNA
L
SA
VRDV
LRENQDIY
L
V
NE
G
AN
T
L
D
N
A
RN
I
IDMYK
PR
RR
L
D
C
G
--------
TW
G
V
MG
I
G
MG
Y
AIGA
SV
T
S
G
S-P
VV
A
IE
GD
S
AFG
F
SGM
E
IE
T
IC
R
YN
LPV
T
IV
IF
NN
G-
-
G
I
Y
R
G
DGVD
L
SGAGAPSPTDLMHH
-----------
AR
Y
DK
L
M
D
A
F
R
GV
G
YN
V
TTTD
E
LRH
AL
TTGIQS
---
RK
P
TI
I
N
V
V
ID
PA
AGTESGHIT
KLN
P
K
Q
VA
G
fig|344610.7.peg.3961
Escherichia coli 53638 (13-563/564)
IIV
EA
L
KQN
NI
DT
I
Y
G
VV
G
IP
V
TD
M
A
R
H
A
QAE
-
G
-
I
R
Y
I
GF
RHEQ
S
A
GYA
A
A
A
S
G
FLT
Q
K
P
G
I
--
C
LTV
S
A
PG
F
L
N
G
L
T
A
LA
N
A
TV
N
GF
P
M
I
M
ISG
SSDRAI
VDLQ
Q
G
D
YE
E
L
D
QM
--------
NAAKPYA
K
AAF
R
V
NQP
Q
DL
G
IA
L
AR
A
IRV
S
V
S
-
GRPG
G
V
Y
L
DLP
A
N
V
LAATMEKD
---
EALTTIVKVENPS
P
ALLPCPKS
V
TS
A
ISL
L
AK
A
ER
P
L
I
IL
G
K
G
AAY
S
Q
A
DEQ
L
R
E
FIESTQI
P
FLPM
S
M
AK
G
IL
E
DT
HP
---
--
-
-
L
S
A
AAARSFA
L
A
NAD
V
V
ML
VG
A
R
L
NW
L
LAHGKKG
W
A
A
-
D
T
QF
I
Q
L
DI
E
P
Q
EI
DSNRPIA
V
P
V
VGD
IASS
M
QG
M
L
AE
L
KQNTFTT
PL
V
--
--
W
R
D
ILNIH
K
QQNAQKMHEKLST
D
----------------------------
T
-
-QPLNYFNA
L
SA
VRDV
LRENQDIY
L
V
NE
G
AN
T
L
D
N
A
RN
I
IDMYK
PR
RR
L
D
C
G
--------
TW
G
V
MG
I
G
MG
Y
AIGA
SV
T
S
G
S-P
VV
A
IE
GD
S
AFG
F
SGM
E
IE
T
IC
R
YN
LPV
T
IV
IF
NN
G-
-
G
I
Y
R
G
DGVD
L
SGAGAPSPTDLMHH
-----------
AR
Y
DK
L
M
D
A
F
R
GV
G
YN
V
TTTD
E
LRH
AL
TTGIQS
---
RK
P
TI
I
N
V
V
ID
PA
AGTESGHIT
KLN
P
K
Q
VA
G
fig|481805.3.peg.1386
Escherichia coli ATCC 8739 (13-563/564)
IIV
EA
L
KQN
NI
DT
I
Y
G
VV
G
IP
V
TD
M
A
R
H
A
QAE
-
G
-
I
R
Y
I
GF
RHEQ
S
A
GYA
A
A
A
S
G
FLT
Q
K
P
G
I
--
C
LTV
S
A
PG
F
L
N
G
L
T
A
LA
N
A
TV
N
GF
P
M
I
M
ISG
SSDRAI
VDLQ
Q
G
D
YE
E
L
D
QM
--------
NAAKPYA
K
AAF
R
V
NQP
Q
DL
G
IA
L
AR
A
IRV
S
V
S
-
GRPG
G
V
Y
L
DLP
A
N
V
LAATMEKD
---
EALTTIVKVENPS
P
ALLPCPKS
V
TS
A
ISL
L
AK
A
ER
P
L
I
IL
G
K
G
AAY
S
Q
A
DEQ
L
R
E
FIESTQI
P
FLPM
S
M
AK
G
IL
E
DT
HP
---
--
-
-
L
S
A
AAARSFA
L
A
NAD
V
V
ML
VG
A
R
L
NW
L
LAHGKKG
W
A
A
-
D
T
QF
I
Q
L
DI
E
P
Q
EI
DSNRPIA
V
P
V
VGD
IASS
M
QG
M
L
AE
L
KQNTFTT
PL
V
--
--
W
R
D
ILNIH
K
QQNAQKMHEKLST
D
----------------------------
T
-
-QPLNYFNA
L
SA
VRDV
LRENQDIY
L
V
NE
G
AN
T
L
D
N
A
RN
I
IDMYK
PR
RR
L
D
C
G
--------
TW
G
V
MG
I
G
MG
Y
AIGA
SV
T
S
G
S-P
VV
A
IE
GD
S
AFG
F
SGM
E
IE
T
IC
R
YN
LPV
T
IV
IF
NN
G-
-
G
I
Y
R
G
DGVD
L
SGAGAPSPTDLMHH
-----------
AR
Y
DK
L
M
D
A
F
R
GV
G
YN
V
TTTD
E
LRH
AL
TTGIQS
---
RK
P
TI
I
N
V
V
ID
PA
AGTESGHIT
KLN
P
K
Q
VA
G
fig|481805.6.peg.1386
Escherichia coli ATCC 8739 (13-563/564)
IIV
EA
L
KQN
NI
DT
I
Y
G
VV
G
IP
V
TD
M
A
R
H
A
QAE
-
G
-
I
R
Y
I
GF
RHEQ
S
A
GYA
A
A
A
S
G
FLT
Q
K
P
G
I
--
C
LTV
S
A
PG
F
L
N
G
L
T
A
LA
N
A
TV
N
GF
P
M
I
M
ISG
SSDRAI
VDLQ
Q
G
D
YE
E
L
D
QM
--------
NAAKPYA
K
AAF
R
V
NQP
Q
DL
G
IA
L
AR
A
IRV
S
V
S
-
GRPG
G
V
Y
L
DLP
A
N
V
LAATMEKD
---
EALTTIVKVENPS
P
ALLPCPKS
V
TS
A
ISL
L
AK
A
ER
P
L
I
IL
G
K
G
AAY
S
Q
A
DEQ
L
R
E
FIESTQI
P
FLPM
S
M
AK
G
IL
E
DT
HP
---
--
-
-
L
S
A
AAARSFA
L
A
NAD
V
V
ML
VG
A
R
L
NW
L
LAHGKKG
W
A
A
-
D
T
QF
I
Q
L
DI
E
P
Q
EI
DSNRPIA
V
P
V
VGD
IASS
M
QG
M
L
AE
L
KQNTFTT
PL
V
--
--
W
R
D
ILNIH
K
QQNAQKMHEKLST
D
----------------------------
T
-
-QPLNYFNA
L
SA
VRDV
LRENQDIY
L
V
NE
G
AN
T
L
D
N
A
RN
I
IDMYK
PR
RR
L
D
C
G
--------
TW
G
V
MG
I
G
MG
Y
AIGA
SV
T
S
G
S-P
VV
A
IE
GD
S
AFG
F
SGM
E
IE
T
IC
R
YN
LPV
T
IV
IF
NN
G-
-
G
I
Y
R
G
DGVD
L
SGAGAPSPTDLMHH
-----------
AR
Y
DK
L
M
D
A
F
R
GV
G
YN
V
TTTD
E
LRH
AL
TTGIQS
---
RK
P
TI
I
N
V
V
ID
PA
AGTESGHIT
KLN
P
K
Q
VA
G
fig|550676.3.peg.1582
Escherichia coli B185 (13-563/564)
IIV
EA
L
KQN
NI
DT
I
Y
G
VV
G
IP
V
TD
M
A
R
H
A
QAE
-
G
-
I
R
Y
I
GF
RHEQ
S
A
GYA
A
A
A
S
G
FLT
Q
K
P
G
I
--
C
LTV
S
A
PG
F
L
N
G
L
T
A
LA
N
A
TV
N
GF
P
M
I
M
ISG
SSDRAI
VDLQ
Q
G
D
YE
E
L
D
QM
--------
NAAKPYA
K
AAF
R
V
NQP
Q
DL
G
IA
L
AR
A
IRV
S
V
S
-
GRPG
G
V
Y
L
DLP
A
N
V
LAATMEKD
---
EALTTIVKVENPS
P
ALLPCPKS
V
AS
A
ISL
L
AK
A
ER
P
L
V
IL
G
K
G
AAY
S
Q
A
DEQ
L
R
E
FIESAQI
P
FLPM
S
M
AK
G
IL
E
DT
HP
---
--
-
-
L
S
A
AAARSFA
L
A
NAD
V
V
ML
VG
A
R
L
NW
L
LAHGKKG
W
A
A
-
D
T
QF
I
Q
L
DI
E
P
Q
EI
DSNRPIA
V
P
V
VGD
IASS
M
QG
M
L
AE
L
KQNTFTT
PL
V
--
--
W
R
D
ILNIH
K
QQNAQKMHEKLST
D
----------------------------
T
-
-QPLNYFNA
L
SA
VRDV
LRENQDIY
L
V
NE
G
AN
T
L
D
N
A
RN
I
IDMYK
PR
RR
L
D
C
G
--------
TW
G
V
MG
I
G
MG
Y
AIGA
SV
T
S
G
S-P
VV
A
IE
GD
S
AFG
F
SGM
E
IE
T
IC
R
YN
LPV
T
IV
IF
NN
G-
-
G
I
Y
R
G
DGVD
L
SGAGAPSPTDLLHH
-----------
AR
Y
DK
L
M
D
A
F
R
GV
G
YN
V
TTTD
E
LRH
AL
TTGIQS
---
RK
P
TI
I
N
V
V
ID
PA
AGTESGHIT
KLN
P
K
Q
VA
G
fig|585057.4.peg.2617
Escherichia coli IAI39 (13-563/564)
IIV
EA
L
KQN
NI
DT
I
Y
G
VV
G
IP
V
TD
M
A
R
H
A
QAE
-
G
-
I
R
Y
I
GF
RHEQ
S
A
GYA
A
A
A
S
G
FLT
Q
K
P
G
I
--
C
LTV
S
A
PG
F
L
N
G
L
T
A
LA
N
A
TV
N
GF
P
M
I
M
ISG
SSDRAI
VDLQ
Q
G
D
YE
E
L
D
QM
--------
NAAKPYA
K
AAF
R
V
NQP
Q
DL
G
IA
L
AR
A
IRV
S
V
S
-
GRPG
G
V
Y
L
DLP
A
N
V
LAATMEKD
---
EALTTIVKVENPS
P
ALLPCPKS
V
AS
A
ISL
L
AK
A
ER
P
L
V
IL
G
K
G
AAY
S
Q
A
DEQ
L
R
E
FIESAQI
P
FLPM
S
M
AK
G
IL
E
DT
HP
---
--
-
-
L
S
A
AAARSFA
L
A
NAD
V
V
ML
VG
A
R
L
NW
L
LAHGKKG
W
A
A
-
D
T
QF
I
Q
L
DI
E
P
Q
EI
DSNRPIA
V
P
V
VGD
IASS
M
QG
M
L
AE
L
KQNTFTT
PL
V
--
--
W
R
D
ILNIH
K
QQNAQKMHEKLST
D
----------------------------
T
-
-QPLNYFNA
L
SA
VRDV
LRENQDIY
L
V
NE
G
AN
T
L
D
N
A
RN
I
IDMYK
PR
RR
L
D
C
G
--------
TW
G
V
MG
I
G
MG
Y
AIGA
SV
T
S
G
S-P
VV
A
IE
GD
S
AFG
F
SGM
E
IE
T
IC
R
YN
LPV
T
IV
IF
NN
G-
-
G
I
Y
R
G
DGVD
L
SGAGAPSPTDLLHH
-----------
AR
Y
DK
L
M
D
A
F
R
GV
G
YN
V
TTTD
E
LRH
AL
TTGIQS
---
RK
P
TI
I
N
V
V
ID
PA
AGTESGHIT
KLN
P
K
Q
VA
G
fig|585057.6.peg.2620
Escherichia coli IAI39 (13-563/564)
IIV
EA
L
KQN
NI
DT
I
Y
G
VV
G
IP
V
TD
M
A
R
H
A
QAE
-
G
-
I
R
Y
I
GF
RHEQ
S
A
GYA
A
A
A
S
G
FLT
Q
K
P
G
I
--
C
LTV
S
A
PG
F
L
N
G
L
T
A
LA
N
A
TV
N
GF
P
M
I
M
ISG
SSDRAI
VDLQ
Q
G
D
YE
E
L
D
QM
--------
NAAKPYA
K
AAF
R
V
NQP
Q
DL
G
IA
L
AR
A
IRV
S
V
S
-
GRPG
G
V
Y
L
DLP
A
N
V
LAATMEKD
---
EALTTIVKVENPS
P
ALLPCPKS
V
AS
A
ISL
L
AK
A
ER
P
L
V
IL
G
K
G
AAY
S
Q
A
DEQ
L
R
E
FIESAQI
P
FLPM
S
M
AK
G
IL
E
DT
HP
---
--
-
-
L
S
A
AAARSFA
L
A
NAD
V
V
ML
VG
A
R
L
NW
L
LAHGKKG
W
A
A
-
D
T
QF
I
Q
L
DI
E
P
Q
EI
DSNRPIA
V
P
V
VGD
IASS
M
QG
M
L
AE
L
KQNTFTT
PL
V
--
--
W
R
D
ILNIH
K
QQNAQKMHEKLST
D
----------------------------
T
-
-QPLNYFNA
L
SA
VRDV
LRENQDIY
L
V
NE
G
AN
T
L
D
N
A
RN
I
IDMYK
PR
RR
L
D
C
G
--------
TW
G
V
MG
I
G
MG
Y
AIGA
SV
T
S
G
S-P
VV
A
IE
GD
S
AFG
F
SGM
E
IE
T
IC
R
YN
LPV
T
IV
IF
NN
G-
-
G
I
Y
R
G
DGVD
L
SGAGAPSPTDLLHH
-----------
AR
Y
DK
L
M
D
A
F
R
GV
G
YN
V
TTTD
E
LRH
AL
TTGIQS
---
RK
P
TI
I
N
V
V
ID
PA
AGTESGHIT
KLN
P
K
Q
VA
G
fig|670897.3.peg.3340
Escherichia coli 2362-75 (13-563/564)
IIV
EA
L
KQN
NI
DT
I
Y
G
VV
G
IP
V
TD
M
A
R
H
A
QAE
-
G
-
I
R
Y
I
GF
RHEQ
S
A
GYA
A
A
A
S
G
FLT
Q
K
P
G
I
--
C
LTV
S
A
PG
F
L
N
G
L
T
A
LA
N
A
TV
N
GF
P
M
I
M
ISG
SSDRAI
VDLQ
Q
G
D
YE
E
L
D
QM
--------
NAAKPYA
K
AAF
R
V
NQP
Q
DL
G
IA
L
AR
A
IRV
S
V
S
-
GRPG
G
V
Y
L
DLP
A
N
V
LAATMEKD
---
EALTTIVKVENPS
P
ALLPCPKS
V
AS
A
ISL
L
AK
A
ER
P
L
V
IL
G
K
G
AAY
S
Q
S
DEQ
L
R
E
FIESAQI
P
FLPM
S
M
AK
G
IL
E
DT
HP
---
--
-
-
L
S
A
AAARSFA
L
A
NAD
V
V
ML
VG
A
R
L
NW
L
LAHGKKG
W
A
A
-
D
T
QF
I
Q
L
DI
E
P
Q
EI
DSNRPIA
V
P
V
VGD
IASS
M
QG
M
L
AE
L
KQNTFTT
PL
V
--
--
W
R
D
ILNIH
K
QQNAQKMHEKLST
D
----------------------------
T
-
-QPLNYFNA
L
SA
VRDV
LRENQDIY
L
V
NE
G
AN
T
L
D
N
A
RN
I
IDMYK
PR
RR
L
D
C
G
--------
TW
G
V
MG
I
G
MG
Y
AIGA
SV
T
S
G
S-P
VV
A
IE
GD
S
AFG
F
SGM
E
IE
T
IC
R
YN
LPV
T
IV
IF
NN
G-
-
G
I
Y
R
G
DGVD
L
SGAGAPSPTDLLHH
-----------
AR
Y
DK
L
M
D
A
F
R
GV
G
YN
V
TTTD
E
LRH
AL
TTGIQS
---
RK
P
TI
I
N
V
V
ID
PA
AGTESGHIT
KLN
P
K
Q
VA
G
fig|216593.1.peg.833
Escherichia coli E2348/69 (13-563/564)
IIV
EA
L
KQN
NI
DT
I
Y
G
VV
G
IP
V
TD
M
A
R
H
A
QAE
-
G
-
I
R
Y
I
GF
RHEQ
S
A
GYA
A
A
A
S
G
FLT
Q
K
P
G
I
--
C
LTV
S
A
PG
F
L
N
G
L
T
A
LA
N
A
TV
N
GF
P
M
I
M
ISG
SSDRAI
VDLQ
Q
G
D
YE
E
L
D
QM
--------
NAAKPYA
K
AAF
R
V
NQP
Q
DL
G
IA
L
AR
A
IRV
S
V
S
-
GRPG
G
V
Y
L
DLP
A
N
V
LAATMEKD
---
EALTTIVKVENPS
P
ALLPCPKS
V
AS
A
ISL
L
AK
A
ER
P
L
V
IL
G
K
G
AAY
S
Q
S
DEQ
L
R
E
FIESAQI
P
FLPM
S
M
AK
G
IL
E
DT
HP
---
--
-
-
L
S
A
AAARSFA
L
A
NAD
V
V
ML
VG
A
R
L
NW
L
LAHGKKG
W
A
A
-
D
T
QF
I
Q
L
DI
E
P
Q
EI
DSNRPIA
V
P
V
VGD
IASS
M
QG
M
L
AE
L
KQNTFTT
PL
V
--
--
W
R
D
ILNIH
K
QQNAQKMHEKLST
D
----------------------------
T
-
-QPLNYFNA
L
SA
VRDV
LRENQDIY
L
V
NE
G
AN
T
L
D
N
A
RN
I
IDMYK
PR
RR
L
D
C
G
--------
TW
G
V
MG
I
G
MG
Y
AIGA
SV
T
S
G
S-P
VV
A
IE
GD
S
AFG
F
SGM
E
IE
T
IC
R
YN
LPV
T
IV
IF
NN
G-
-
G
I
Y
R
G
DGVD
L
SGAGAPSPTDLLHH
-----------
AR
Y
DK
L
M
D
A
F
R
GV
G
YN
V
TTTD
E
LRH
AL
TTGIQS
---
RK
P
TI
I
N
V
V
ID
PA
AGTESGHIT
KLN
P
K
Q
VA
G
fig|574521.7.peg.2609
Escherichia coli O127:H6 str. E2348/69 (13-563/564)
IIV
EA
L
KQN
NI
DT
I
Y
G
VV
G
IP
V
TD
M
A
R
H
A
QAE
-
G
-
I
R
Y
I
GF
RHEQ
S
A
GYA
A
A
A
S
G
FLT
Q
K
P
G
I
--
C
LTV
S
A
PG
F
L
N
G
L
T
A
LA
N
A
TV
N
GF
P
M
I
M
ISG
SSDRAI
VDLQ
Q
G
D
YE
E
L
D
QM
--------
NAAKPYA
K
AAF
R
V
NQP
Q
DL
G
IA
L
AR
A
IRV
S
V
S
-
GRPG
G
V
Y
L
DLP
A
N
V
LAATMEKD
---
EALTTIVKVENPS
P
ALLPCPKS
V
AS
A
ISL
L
AK
A
ER
P
L
V
IL
G
K
G
AAY
S
Q
S
DEQ
L
R
E
FIESAQI
P
FLPM
S
M
AK
G
IL
E
DT
HP
---
--
-
-
L
S
A
AAARSFA
L
A
NAD
V
V
ML
VG
A
R
L
NW
L
LAHGKKG
W
A
A
-
D
T
QF
I
Q
L
DI
E
P
Q
EI
DSNRPIA
V
P
V
VGD
IASS
M
QG
M
L
AE
L
KQNTFTT
PL
V
--
--
W
R
D
ILNIH
K
QQNAQKMHEKLST
D
----------------------------
T
-
-QPLNYFNA
L
SA
VRDV
LRENQDIY
L
V
NE
G
AN
T
L
D
N
A
RN
I
IDMYK
PR
RR
L
D
C
G
--------
TW
G
V
MG
I
G
MG
Y
AIGA
SV
T
S
G
S-P
VV
A
IE
GD
S
AFG
F
SGM
E
IE
T
IC
R
YN
LPV
T
IV
IF
NN
G-
-
G
I
Y
R
G
DGVD
L
SGAGAPSPTDLLHH
-----------
AR
Y
DK
L
M
D
A
F
R
GV
G
YN
V
TTTD
E
LRH
AL
TTGIQS
---
RK
P
TI
I
N
V
V
ID
PA
AGTESGHIT
KLN
P
K
Q
VA
G
fig|550672.3.peg.2107
Escherichia coli B088 (13-563/564)
IIV
EA
L
KQN
NI
DT
I
Y
G
VV
G
IP
V
TD
M
A
R
H
A
QAE
-
G
-
I
R
Y
I
GF
RHEQ
S
A
GYA
A
A
A
S
G
FLT
Q
K
P
G
I
--
C
LTV
S
A
PG
F
L
N
G
L
T
A
LA
N
A
TV
N
GF
P
M
I
M
ISG
SSDRAI
VDLQ
Q
G
D
YE
E
L
D
QM
--------
NAAKPYA
K
AAF
R
V
NQP
Q
DL
G
IA
L
AR
A
IRV
S
V
S
-
GRPG
G
V
Y
L
DLP
A
N
V
LAATMEKD
---
EALTTIVKVENPS
P
ALLPCPKS
V
TS
A
ISL
L
AK
A
ER
P
L
I
IL
G
K
G
AAY
S
Q
A
DEQ
L
R
E
FIESTQI
P
FLPM
S
M
AK
G
IL
E
DT
HP
---
--
-
-
L
S
A
AAARSFA
L
A
NAD
V
V
ML
VG
A
R
L
NW
L
LAHGKKG
W
A
A
-
D
T
QF
I
Q
L
DI
E
P
Q
EI
DSNRPIA
V
P
V
VGD
IASS
M
QG
M
L
AE
L
KQNTFTT
PL
V
--
--
W
R
D
ILNIH
K
QQNAQKMHEKLST
D
----------------------------
T
-
-QPLNYFNA
L
SA
VRDV
LRENQDIY
L
V
NE
G
AN
T
L
D
N
A
RN
I
IDMYK
PR
RR
L
D
C
G
--------
TW
G
V
MG
I
G
MG
Y
AIGA
SV
T
S
G
S-P
VV
A
IE
GD
S
AFG
F
SGM
E
IE
T
IC
R
YN
LPV
T
IV
IF
NN
G-
-
G
I
Y
R
G
DGVD
L
SGAGAPSPTDLLHH
-----------
AR
Y
DK
L
M
D
A
F
R
GV
G
YN
V
TTTD
E
LRH
AL
TTGIQS
---
RK
P
TI
I
N
V
V
ID
PA
AGTESGHIT
KLN
P
K
Q
VA
G
fig|344601.3.peg.2947
Escherichia coli B171 (13-563/564)
IIV
EA
L
KQN
NI
DT
I
Y
G
VV
G
IP
V
TD
M
A
R
H
A
QAE
-
G
-
I
R
Y
I
GF
RHEQ
S
A
GYA
A
A
A
S
G
FLT
Q
K
P
G
I
--
C
LTV
S
A
PG
F
L
N
G
L
T
A
LA
N
A
TV
N
GF
P
M
I
M
ISG
SSDRAI
VDLQ
Q
G
D
YE
E
L
D
QM
--------
NAAKPYA
K
AAF
R
V
NQP
Q
DL
G
IA
L
AR
A
IRV
S
V
S
-
GRPG
G
V
Y
L
DLP
A
N
V
LAATMEKD
---
EALTTIVKVENPS
P
ALLPCPKS
V
TS
A
ISL
L
AK
A
ER
P
L
I
IL
G
K
G
AAY
S
Q
A
DEQ
L
R
E
FIESTQI
P
FLPM
S
M
AK
G
IL
E
DT
HP
---
--
-
-
L
S
A
AAARSFA
L
A
NAD
V
V
ML
VG
A
R
L
NW
L
LAHGKKG
W
A
A
-
D
T
QF
I
Q
L
DI
E
P
Q
EI
DSNRPIA
V
P
V
VGD
IASS
M
QG
M
L
AE
L
KQNTFTT
PL
V
--
--
W
R
D
ILNIH
K
QQNAQKMHEKLST
D
----------------------------
T
-
-QPLNYFNA
L
SA
VRDV
LRENQDIY
L
V
NE
G
AN
T
L
D
N
A
RN
I
IDMYK
PR
RR
L
D
C
G
--------
TW
G
V
MG
I
G
MG
Y
AIGA
SV
T
S
G
S-P
VV
A
IE
GD
S
AFG
F
SGM
E
IE
T
IC
R
YN
LPV
T
IV
IF
NN
G-
-
G
I
Y
R
G
DGVD
L
SGAGAPSPTDLLHH
-----------
AR
Y
DK
L
M
D
A
F
R
GV
G
YN
V
TTTD
E
LRH
AL
TTGIQS
---
RK
P
TI
I
N
V
V
ID
PA
AGTESGHIT
KLN
P
K
Q
VA
G
fig|344601.5.peg.3071
Escherichia coli B171 (13-563/564)
IIV
EA
L
KQN
NI
DT
I
Y
G
VV
G
IP
V
TD
M
A
R
H
A
QAE
-
G
-
I
R
Y
I
GF
RHEQ
S
A
GYA
A
A
A
S
G
FLT
Q
K
P
G
I
--
C
LTV
S
A
PG
F
L
N
G
L
T
A
LA
N
A
TV
N
GF
P
M
I
M
ISG
SSDRAI
VDLQ
Q
G
D
YE
E
L
D
QM
--------
NAAKPYA
K
AAF
R
V
NQP
Q
DL
G
IA
L
AR
A
IRV
S
V
S
-
GRPG
G
V
Y
L
DLP
A
N
V
LAATMEKD
---
EALTTIVKVENPS
P
ALLPCPKS
V
TS
A
ISL
L
AK
A
ER
P
L
I
IL
G
K
G
AAY
S
Q
A
DEQ
L
R
E
FIESTQI
P
FLPM
S
M
AK
G
IL
E
DT
HP
---
--
-
-
L
S
A
AAARSFA
L
A
NAD
V
V
ML
VG
A
R
L
NW
L
LAHGKKG
W
A
A
-
D
T
QF
I
Q
L
DI
E
P
Q
EI
DSNRPIA
V
P
V
VGD
IASS
M
QG
M
L
AE
L
KQNTFTT
PL
V
--
--
W
R
D
ILNIH
K
QQNAQKMHEKLST
D
----------------------------
T
-
-QPLNYFNA
L
SA
VRDV
LRENQDIY
L
V
NE
G
AN
T
L
D
N
A
RN
I
IDMYK
PR
RR
L
D
C
G
--------
TW
G
V
MG
I
G
MG
Y
AIGA
SV
T
S
G
S-P
VV
A
IE
GD
S
AFG
F
SGM
E
IE
T
IC
R
YN
LPV
T
IV
IF
NN
G-
-
G
I
Y
R
G
DGVD
L
SGAGAPSPTDLLHH
-----------
AR
Y
DK
L
M
D
A
F
R
GV
G
YN
V
TTTD
E
LRH
AL
TTGIQS
---
RK
P
TI
I
N
V
V
ID
PA
AGTESGHIT
KLN
P
K
Q
VA
G
fig|340184.3.peg.521
Escherichia coli B7A (13-563/564)
IIV
EA
L
KQN
NI
DT
I
Y
G
VV
G
IP
V
TD
M
A
R
H
A
QAE
-
G
-
I
R
Y
I
GF
RHEQ
S
A
GYA
A
A
A
S
G
FLT
Q
K
P
G
I
--
C
LTV
S
A
PG
F
L
N
G
L
T
A
LA
N
A
TV
N
GF
P
M
I
M
ISG
SSDRAI
VDLQ
Q
G
D
YE
E
L
D
QM
--------
NAAKPYA
K
AAF
R
V
NQP
Q
DL
G
IA
L
AR
A
IRV
S
V
S
-
GRPG
G
V
Y
L
DLP
A
N
V
LAATMEKD
---
EALTTIVKVENPS
P
ALLPCPKS
V
TS
A
ISL
L
AK
A
ER
P
L
I
IL
G
K
G
AAY
S
Q
A
DEQ
L
R
E
FIESTQI
P
FLPM
S
M
AK
G
IL
E
DT
HP
---
--
-
-
L
S
A
AAARSFA
L
A
NAD
V
V
ML
VG
A
R
L
NW
L
LAHGKKG
W
A
A
-
D
T
QF
I
Q
L
DI
E
P
Q
EI
DSNRPIA
V
P
V
VGD
IASS
M
QG
M
L
AE
L
KQNTFTT
PL
V
--
--
W
R
D
ILNIH
K
QQNAQKMHEKLST
D
----------------------------
T
-
-QPLNYFNA
L
SA
VRDV
LRENQDIY
L
V
NE
G
AN
T
L
D
N
A
RN
I
IDMYK
PR
RR
L
D
C
G
--------
TW
G
V
MG
I
G
MG
Y
AIGA
SV
T
S
G
S-P
VV
A
IE
GD
S
AFG
F
SGM
E
IE
T
IC
R
YN
LPV
T
IV
IF
NN
G-
-
G
I
Y
R
G
DGVD
L
SGAGAPSPTDLLHH
-----------
AR
Y
DK
L
M
D
A
F
R
GV
G
YN
V
TTTD
E
LRH
AL
TTGIQS
---
RK
P
TI
I
N
V
V
ID
PA
AGTESGHIT
KLN
P
K
Q
VA
G
fig|340184.6.peg.543
Escherichia coli B7A (13-563/564)
IIV
EA
L
KQN
NI
DT
I
Y
G
VV
G
IP
V
TD
M
A
R
H
A
QAE
-
G
-
I
R
Y
I
GF
RHEQ
S
A
GYA
A
A
A
S
G
FLT
Q
K
P
G
I
--
C
LTV
S
A
PG
F
L
N
G
L
T
A
LA
N
A
TV
N
GF
P
M
I
M
ISG
SSDRAI
VDLQ
Q
G
D
YE
E
L
D
QM
--------
NAAKPYA
K
AAF
R
V
NQP
Q
DL
G
IA
L
AR
A
IRV
S
V
S
-
GRPG
G
V
Y
L
DLP
A
N
V
LAATMEKD
---
EALTTIVKVENPS
P
ALLPCPKS
V
TS
A
ISL
L
AK
A
ER
P
L
I
IL
G
K
G
AAY
S
Q
A
DEQ
L
R
E
FIESTQI
P
FLPM
S
M
AK
G
IL
E
DT
HP
---
--
-
-
L
S
A
AAARSFA
L
A
NAD
V
V
ML
VG
A
R
L
NW
L
LAHGKKG
W
A
A
-
D
T
QF
I
Q
L
DI
E
P
Q
EI
DSNRPIA
V
P
V
VGD
IASS
M
QG
M
L
AE
L
KQNTFTT
PL
V
--
--
W
R
D
ILNIH
K
QQNAQKMHEKLST
D
----------------------------
T
-
-QPLNYFNA
L
SA
VRDV
LRENQDIY
L
V
NE
G
AN
T
L
D
N
A
RN
I
IDMYK
PR
RR
L
D
C
G
--------
TW
G
V
MG
I
G
MG
Y
AIGA
SV
T
S
G
S-P
VV
A
IE
GD
S
AFG
F
SGM
E
IE
T
IC
R
YN
LPV
T
IV
IF
NN
G-
-
G
I
Y
R
G
DGVD
L
SGAGAPSPTDLLHH
-----------
AR
Y
DK
L
M
D
A
F
R
GV
G
YN
V
TTTD
E
LRH
AL
TTGIQS
---
RK
P
TI
I
N
V
V
ID
PA
AGTESGHIT
KLN
P
K
Q
VA
G
fig|340185.3.peg.789
Escherichia coli E22 (13-563/564)
IIV
EA
L
KQN
NI
DT
I
Y
G
VV
G
IP
V
TD
M
A
R
H
A
QAE
-
G
-
I
R
Y
I
GF
RHEQ
S
A
GYA
A
A
A
S
G
FLT
Q
K
P
G
I
--
C
LTV
S
A
PG
F
L
N
G
L
T
A
LA
N
A
TV
N
GF
P
M
I
M
ISG
SSDRAI
VDLQ
Q
G
D
YE
E
L
D
QM
--------
NAAKPYA
K
AAF
R
V
NQP
Q
DL
G
IA
L
AR
A
IRV
S
V
S
-
GRPG
G
V
Y
L
DLP
A
N
V
LAATMEKD
---
EALTTIVKVENPS
P
ALLPCPKS
V
TS
A
ISL
L
AK
A
ER
P
L
I
IL
G
K
G
AAY
S
Q
A
DEQ
L
R
E
FIESTQI
P
FLPM
S
M
AK
G
IL
E
DT
HP
---
--
-
-
L
S
A
AAARSFA
L
A
NAD
V
V
ML
VG
A
R
L
NW
L
LAHGKKG
W
A
A
-
D
T
QF
I
Q
L
DI
E
P
Q
EI
DSNRPIA
V
P
V
VGD
IASS
M
QG
M
L
AE
L
KQNTFTT
PL
V
--
--
W
R
D
ILNIH
K
QQNAQKMHEKLST
D
----------------------------
T
-
-QPLNYFNA
L
SA
VRDV
LRENQDIY
L
V
NE
G
AN
T
L
D
N
A
RN
I
IDMYK
PR
RR
L
D
C
G
--------
TW
G
V
MG
I
G
MG
Y
AIGA
SV
T
S
G
S-P
VV
A
IE
GD
S
AFG
F
SGM
E
IE
T
IC
R
YN
LPV
T
IV
IF
NN
G-
-
G
I
Y
R
G
DGVD
L
SGAGAPSPTDLLHH
-----------
AR
Y
DK
L
M
D
A
F
R
GV
G
YN
V
TTTD
E
LRH
AL
TTGIQS
---
RK
P
TI
I
N
V
V
ID
PA
AGTESGHIT
KLN
P
K
Q
VA
G
fig|340185.4.peg.831
Escherichia coli E22 (13-563/564)
IIV
EA
L
KQN
NI
DT
I
Y
G
VV
G
IP
V
TD
M
A
R
H
A
QAE
-
G
-
I
R
Y
I
GF
RHEQ
S
A
GYA
A
A
A
S
G
FLT
Q
K
P
G
I
--
C
LTV
S
A
PG
F
L
N
G
L
T
A
LA
N
A
TV
N
GF
P
M
I
M
ISG
SSDRAI
VDLQ
Q
G
D
YE
E
L
D
QM
--------
NAAKPYA
K
AAF
R
V
NQP
Q
DL
G
IA
L
AR
A
IRV
S
V
S
-
GRPG
G
V
Y
L
DLP
A
N
V
LAATMEKD
---
EALTTIVKVENPS
P
ALLPCPKS
V
TS
A
ISL
L
AK
A
ER
P
L
I
IL
G
K
G
AAY
S
Q
A
DEQ
L
R
E
FIESTQI
P
FLPM
S
M
AK
G
IL
E
DT
HP
---
--
-
-
L
S
A
AAARSFA
L
A
NAD
V
V
ML
VG
A
R
L
NW
L
LAHGKKG
W
A
A
-
D
T
QF
I
Q
L
DI
E
P
Q
EI
DSNRPIA
V
P
V
VGD
IASS
M
QG
M
L
AE
L
KQNTFTT
PL
V
--
--
W
R
D
ILNIH
K
QQNAQKMHEKLST
D
----------------------------
T
-
-QPLNYFNA
L
SA
VRDV
LRENQDIY
L
V
NE
G
AN
T
L
D
N
A
RN
I
IDMYK
PR
RR
L
D
C
G
--------
TW
G
V
MG
I
G
MG
Y
AIGA
SV
T
S
G
S-P
VV
A
IE
GD
S
AFG
F
SGM
E
IE
T
IC
R
YN
LPV
T
IV
IF
NN
G-
-
G
I
Y
R
G
DGVD
L
SGAGAPSPTDLLHH
-----------
AR
Y
DK
L
M
D
A
F
R
GV
G
YN
V
TTTD
E
LRH
AL
TTGIQS
---
RK
P
TI
I
N
V
V
ID
PA
AGTESGHIT
KLN
P
K
Q
VA
G
fig|562.375.peg.3357
Escherichia coli EC4100B (13-563/564)
IIV
EA
L
KQN
NI
DT
I
Y
G
VV
G
IP
V
TD
M
A
R
H
A
QAE
-
G
-
I
R
Y
I
GF
RHEQ
S
A
GYA
A
A
A
S
G
FLT
Q
K
P
G
I
--
C
LTV
S
A
PG
F
L
N
G
L
T
A
LA
N
A
TV
N
GF
P
M
I
M
ISG
SSDRAI
VDLQ
Q
G
D
YE
E
L
D
QM
--------
NAAKPYA
K
AAF
R
V
NQP
Q
DL
G
IA
L
AR
A
IRV
S
V
S
-
GRPG
G
V
Y
L
DLP
A
N
V
LAATMEKD
---
EALTTIVKVENPS
P
ALLPCPKS
V
TS
A
ISL
L
AK
A
ER
P
L
I
IL
G
K
G
AAY
S
Q
A
DEQ
L
R
E
FIESTQI
P
FLPM
S
M
AK
G
IL
E
DT
HP
---
--
-
-
L
S
A
AAARSFA
L
A
NAD
V
V
ML
VG
A
R
L
NW
L
LAHGKKG
W
A
A
-
D
T
QF
I
Q
L
DI
E
P
Q
EI
DSNRPIA
V
P
V
VGD
IASS
M
QG
M
L
AE
L
KQNTFTT
PL
V
--
--
W
R
D
ILNIH
K
QQNAQKMHEKLST
D
----------------------------
T
-
-QPLNYFNA
L
SA
VRDV
LRENQDIY
L
V
NE
G
AN
T
L
D
N
A
RN
I
IDMYK
PR
RR
L
D
C
G
--------
TW
G
V
MG
I
G
MG
Y
AIGA
SV
T
S
G
S-P
VV
A
IE
GD
S
AFG
F
SGM
E
IE
T
IC
R
YN
LPV
T
IV
IF
NN
G-
-
G
I
Y
R
G
DGVD
L
SGAGAPSPTDLLHH
-----------
AR
Y
DK
L
M
D
A
F
R
GV
G
YN
V
TTTD
E
LRH
AL
TTGIQS
---
RK
P
TI
I
N
V
V
ID
PA
AGTESGHIT
KLN
P
K
Q
VA
G
fig|656408.3.peg.2662
Escherichia coli H591 (13-563/564)
IIV
EA
L
KQN
NI
DT
I
Y
G
VV
G
IP
V
TD
M
A
R
H
A
QAE
-
G
-
I
R
Y
I
GF
RHEQ
S
A
GYA
A
A
A
S
G
FLT
Q
K
P
G
I
--
C
LTV
S
A
PG
F
L
N
G
L
T
A
LA
N
A
TV
N
GF
P
M
I
M
ISG
SSDRAI
VDLQ
Q
G
D
YE
E
L
D
QM
--------
NAAKPYA
K
AAF
R
V
NQP
Q
DL
G
IA
L
AR
A
IRV
S
V
S
-
GRPG
G
V
Y
L
DLP
A
N
V
LAATMEKD
---
EALTTIVKVENPS
P
ALLPCPKS
V
TS
A
ISL
L
AK
A
ER
P
L
I
IL
G
K
G
AAY
S
Q
A
DEQ
L
R
E
FIESTQI
P
FLPM
S
M
AK
G
IL
E
DT
HP
---
--
-
-
L
S
A
AAARSFA
L
A
NAD
V
V
ML
VG
A
R
L
NW
L
LAHGKKG
W
A
A
-
D
T
QF
I
Q
L
DI
E
P
Q
EI
DSNRPIA
V
P
V
VGD
IASS
M
QG
M
L
AE
L
KQNTFTT
PL
V
--
--
W
R
D
ILNIH
K
QQNAQKMHEKLST
D
----------------------------
T
-
-QPLNYFNA
L
SA
VRDV
LRENQDIY
L
V
NE
G
AN
T
L
D
N
A
RN
I
IDMYK
PR
RR
L
D
C
G
--------
TW
G
V
MG
I
G
MG
Y
AIGA
SV
T
S
G
S-P
VV
A
IE
GD
S
AFG
F
SGM
E
IE
T
IC
R
YN
LPV
T
IV
IF
NN
G-
-
G
I
Y
R
G
DGVD
L
SGAGAPSPTDLLHH
-----------
AR
Y
DK
L
M
D
A
F
R
GV
G
YN
V
TTTD
E
LRH
AL
TTGIQS
---
RK
P
TI
I
N
V
V
ID
PA
AGTESGHIT
KLN
P
K
Q
VA
G
fig|585034.4.peg.2405
Escherichia coli IAI1 (13-563/564)
IIV
EA
L
KQN
NI
DT
I
Y
G
VV
G
IP
V
TD
M
A
R
H
A
QAE
-
G
-
I
R
Y
I
GF
RHEQ
S
A
GYA
A
A
A
S
G
FLT
Q
K
P
G
I
--
C
LTV
S
A
PG
F
L
N
G
L
T
A
LA
N
A
TV
N
GF
P
M
I
M
ISG
SSDRAI
VDLQ
Q
G
D
YE
E
L
D
QM
--------
NAAKPYA
K
AAF
R
V
NQP
Q
DL
G
IA
L
AR
A
IRV
S
V
S
-
GRPG
G
V
Y
L
DLP
A
N
V
LAATMEKD
---
EALTTIVKVENPS
P
ALLPCPKS
V
TS
A
ISL
L
AK
A
ER
P
L
I
IL
G
K
G
AAY
S
Q
A
DEQ
L
R
E
FIESTQI
P
FLPM
S
M
AK
G
IL
E
DT
HP
---
--
-
-
L
S
A
AAARSFA
L
A
NAD
V
V
ML
VG
A
R
L
NW
L
LAHGKKG
W
A
A
-
D
T
QF
I
Q
L
DI
E
P
Q
EI
DSNRPIA
V
P
V
VGD
IASS
M
QG
M
L
AE
L
KQNTFTT
PL
V
--
--
W
R
D
ILNIH
K
QQNAQKMHEKLST
D
----------------------------
T
-
-QPLNYFNA
L
SA
VRDV
LRENQDIY
L
V
NE
G
AN
T
L
D
N
A
RN
I
IDMYK
PR
RR
L
D
C
G
--------
TW
G
V
MG
I
G
MG
Y
AIGA
SV
T
S
G
S-P
VV
A
IE
GD
S
AFG
F
SGM
E
IE
T
IC
R
YN
LPV
T
IV
IF
NN
G-
-
G
I
Y
R
G
DGVD
L
SGAGAPSPTDLLHH
-----------
AR
Y
DK
L
M
D
A
F
R
GV
G
YN
V
TTTD
E
LRH
AL
TTGIQS
---
RK
P
TI
I
N
V
V
ID
PA
AGTESGHIT
KLN
P
K
Q
VA
G
fig|585034.5.peg.2403
Escherichia coli IAI1 (13-563/564)
IIV
EA
L
KQN
NI
DT
I
Y
G
VV
G
IP
V
TD
M
A
R
H
A
QAE
-
G
-
I
R
Y
I
GF
RHEQ
S
A
GYA
A
A
A
S
G
FLT
Q
K
P
G
I
--
C
LTV
S
A
PG
F
L
N
G
L
T
A
LA
N
A
TV
N
GF
P
M
I
M
ISG
SSDRAI
VDLQ
Q
G
D
YE
E
L
D
QM
--------
NAAKPYA
K
AAF
R
V
NQP
Q
DL
G
IA
L
AR
A
IRV
S
V
S
-
GRPG
G
V
Y
L
DLP
A
N
V
LAATMEKD
---
EALTTIVKVENPS
P
ALLPCPKS
V
TS
A
ISL
L
AK
A
ER
P
L
I
IL
G
K
G
AAY
S
Q
A
DEQ
L
R
E
FIESTQI
P
FLPM
S
M
AK
G
IL
E
DT
HP
---
--
-
-
L
S
A
AAARSFA
L
A
NAD
V
V
ML
VG
A
R
L
NW
L
LAHGKKG
W
A
A
-
D
T
QF
I
Q
L
DI
E
P
Q
EI
DSNRPIA
V
P
V
VGD
IASS
M
QG
M
L
AE
L
KQNTFTT
PL
V
--
--
W
R
D
ILNIH
K
QQNAQKMHEKLST
D
----------------------------
T
-
-QPLNYFNA
L
SA
VRDV
LRENQDIY
L
V
NE
G
AN
T
L
D
N
A
RN
I
IDMYK
PR
RR
L
D
C
G
--------
TW
G
V
MG
I
G
MG
Y
AIGA
SV
T
S
G
S-P
VV
A
IE
GD
S
AFG
F
SGM
E
IE
T
IC
R
YN
LPV
T
IV
IF
NN
G-
-
G
I
Y
R
G
DGVD
L
SGAGAPSPTDLLHH
-----------
AR
Y
DK
L
M
D
A
F
R
GV
G
YN
V
TTTD
E
LRH
AL
TTGIQS
---
RK
P
TI
I
N
V
V
ID
PA
AGTESGHIT
KLN
P
K
Q
VA
G
fig|679207.4.peg.2388
Escherichia coli MS 107-1 (13-563/564)
IIV
EA
L
KQN
NI
DT
I
Y
G
VV
G
IP
V
TD
M
A
R
H
A
QAE
-
G
-
I
R
Y
I
GF
RHEQ
S
A
GYA
A
A
A
S
G
FLT
Q
K
P
G
I
--
C
LTV
S
A
PG
F
L
N
G
L
T
A
LA
N
A
TV
N
GF
P
M
I
M
ISG
SSDRAI
VDLQ
Q
G
D
YE
E
L
D
QM
--------
NAAKPYA
K
AAF
R
V
NQP
Q
DL
G
IA
L
AR
A
IRV
S
V
S
-
GRPG
G
V
Y
L
DLP
A
N
V
LAATMEKD
---
EALTTIVKVENPS
P
ALLPCPKS
V
TS
A
ISL
L
AK
A
ER
P
L
I
IL
G
K
G
AAY
S
Q
A
DEQ
L
R
E
FIESTQI
P
FLPM
S
M
AK
G
IL
E
DT
HP
---
--
-
-
L
S
A
AAARSFA
L
A
NAD
V
V
ML
VG
A
R
L
NW
L
LAHGKKG
W
A
A
-
D
T
QF
I
Q
L
DI
E
P
Q
EI
DSNRPIA
V
P
V
VGD
IASS
M
QG
M
L
AE
L
KQNTFTT
PL
V
--
--
W
R
D
ILNIH
K
QQNAQKMHEKLST
D
----------------------------
T
-
-QPLNYFNA
L
SA
VRDV
LRENQDIY
L
V
NE
G
AN
T
L
D
N
A
RN
I
IDMYK
PR
RR
L
D
C
G
--------
TW
G
V
MG
I
G
MG
Y
AIGA
SV
T
S
G
S-P
VV
A
IE
GD
S
AFG
F
SGM
E
IE
T
IC
R
YN
LPV
T
IV
IF
NN
G-
-
G
I
Y
R
G
DGVD
L
SGAGAPSPTDLLHH
-----------
AR
Y
DK
L
M
D
A
F
R
GV
G
YN
V
TTTD
E
LRH
AL
TTGIQS
---
RK
P
TI
I
N
V
V
ID
PA
AGTESGHIT
KLN
P
K
Q
VA
G
fig|749538.3.peg.1907
Escherichia coli MS 116-1 (13-563/564)
IIV
EA
L
KQN
NI
DT
I
Y
G
VV
G
IP
V
TD
M
A
R
H
A
QAE
-
G
-
I
R
Y
I
GF
RHEQ
S
A
GYA
A
A
A
S
G
FLT
Q
K
P
G
I
--
C
LTV
S
A
PG
F
L
N
G
L
T
A
LA
N
A
TV
N
GF
P
M
I
M
ISG
SSDRAI
VDLQ
Q
G
D
YE
E
L
D
QM
--------
NAAKPYA
K
AAF
R
V
NQP
Q
DL
G
IA
L
AR
A
IRV
S
V
S
-
GRPG
G
V
Y
L
DLP
A
N
V
LAATMEKD
---
EALTTIVKVENPS
P
ALLPCPKS
V
TS
A
ISL
L
AK
A
ER
P
L
I
IL
G
K
G
AAY
S
Q
A
DEQ
L
R
E
FIESTQI
P
FLPM
S
M
AK
G
IL
E
DT
HP
---
--
-
-
L
S
A
AAARSFA
L
A
NAD
V
V
ML
VG
A
R
L
NW
L
LAHGKKG
W
A
A
-
D
T
QF
I
Q
L
DI
E
P
Q
EI
DSNRPIA
V
P
V
VGD
IASS
M
QG
M
L
AE
L
KQNTFTT
PL
V
--
--
W
R
D
ILNIH
K
QQNAQKMHEKLST
D
----------------------------
T
-
-QPLNYFNA
L
SA
VRDV
LRENQDIY
L
V
NE
G
AN
T
L
D
N
A
RN
I
IDMYK
PR
RR
L
D
C
G
--------
TW
G
V
MG
I
G
MG
Y
AIGA
SV
T
S
G
S-P
VV
A
IE
GD
S
AFG
F
SGM
E
IE
T
IC
R
YN
LPV
T
IV
IF
NN
G-
-
G
I
Y
R
G
DGVD
L
SGAGAPSPTDLLHH
-----------
AR
Y
DK
L
M
D
A
F
R
GV
G
YN
V
TTTD
E
LRH
AL
TTGIQS
---
RK
P
TI
I
N
V
V
ID
PA
AGTESGHIT
KLN
P
K
Q
VA
G
fig|679205.4.peg.3218
Escherichia coli MS 124-1 (13-563/564)
IIV
EA
L
KQN
NI
DT
I
Y
G
VV
G
IP
V
TD
M
A
R
H
A
QAE
-
G
-
I
R
Y
I
GF
RHEQ
S
A
GYA
A
A
A
S
G
FLT
Q
K
P
G
I
--
C
LTV
S
A
PG
F
L
N
G
L
T
A
LA
N
A
TV
N
GF
P
M
I
M
ISG
SSDRAI
VDLQ
Q
G
D
YE
E
L
D
QM
--------
NAAKPYA
K
AAF
R
V
NQP
Q
DL
G
IA
L
AR
A
IRV
S
V
S
-
GRPG
G
V
Y
L
DLP
A
N
V
LAATMEKD
---
EALTTIVKVENPS
P
ALLPCPKS
V
TS
A
ISL
L
AK
A
ER
P
L
I
IL
G
K
G
AAY
S
Q
A
DEQ
L
R
E
FIESTQI
P
FLPM
S
M
AK
G
IL
E
DT
HP
---
--
-
-
L
S
A
AAARSFA
L
A
NAD
V
V
ML
VG
A
R
L
NW
L
LAHGKKG
W
A
A
-
D
T
QF
I
Q
L
DI
E
P
Q
EI
DSNRPIA
V
P
V
VGD
IASS
M
QG
M
L
AE
L
KQNTFTT
PL
V
--
--
W
R
D
ILNIH
K
QQNAQKMHEKLST
D
----------------------------
T
-
-QPLNYFNA
L
SA
VRDV
LRENQDIY
L
V
NE
G
AN
T
L
D
N
A
RN
I
IDMYK
PR
RR
L
D
C
G
--------
TW
G
V
MG
I
G
MG
Y
AIGA
SV
T
S
G
S-P
VV
A
IE
GD
S
AFG
F
SGM
E
IE
T
IC
R
YN
LPV
T
IV
IF
NN
G-
-
G
I
Y
R
G
DGVD
L
SGAGAPSPTDLLHH
-----------
AR
Y
DK
L
M
D
A
F
R
GV
G
YN
V
TTTD
E
LRH
AL
TTGIQS
---
RK
P
TI
I
N
V
V
ID
PA
AGTESGHIT
KLN
P
K
Q
VA
G
fig|679204.3.peg.3912
Escherichia coli MS 145-7 (13-563/564)
IIV
EA
L
KQN
NI
DT
I
Y
G
VV
G
IP
V
TD
M
A
R
H
A
QAE
-
G
-
I
R
Y
I
GF
RHEQ
S
A
GYA
A
A
A
S
G
FLT
Q
K
P
G
I
--
C
LTV
S
A
PG
F
L
N
G
L
T
A
LA
N
A
TV
N
GF
P
M
I
M
ISG
SSDRAI
VDLQ
Q
G
D
YE
E
L
D
QM
--------
NAAKPYA
K
AAF
R
V
NQP
Q
DL
G
IA
L
AR
A
IRV
S
V
S
-
GRPG
G
V
Y
L
DLP
A
N
V
LAATMEKD
---
EALTTIVKVENPS
P
ALLPCPKS
V
TS
A
ISL
L
AK
A
ER
P
L
I
IL
G
K
G
AAY
S
Q
A
DEQ
L
R
E
FIESTQI
P
FLPM
S
M
AK
G
IL
E
DT
HP
---
--
-
-
L
S
A
AAARSFA
L
A
NAD
V
V
ML
VG
A
R
L
NW
L
LAHGKKG
W
A
A
-
D
T
QF
I
Q
L
DI
E
P
Q
EI
DSNRPIA
V
P
V
VGD
IASS
M
QG
M
L
AE
L
KQNTFTT
PL
V
--
--
W
R
D
ILNIH
K
QQNAQKMHEKLST
D
----------------------------
T
-
-QPLNYFNA
L
SA
VRDV
LRENQDIY
L
V
NE
G
AN
T
L
D
N
A
RN
I
IDMYK
PR
RR
L
D
C
G
--------
TW
G
V
MG
I
G
MG
Y
AIGA
SV
T
S
G
S-P
VV
A
IE
GD
S
AFG
F
SGM
E
IE
T
IC
R
YN
LPV
T
IV
IF
NN
G-
-
G
I
Y
R
G
DGVD
L
SGAGAPSPTDLLHH
-----------
AR
Y
DK
L
M
D
A
F
R
GV
G
YN
V
TTTD
E
LRH
AL
TTGIQS
---
RK
P
TI
I
N
V
V
ID
PA
AGTESGHIT
KLN
P
K
Q
VA
G
fig|749544.3.peg.2105
Escherichia coli MS 175-1 (13-563/564)
IIV
EA
L
KQN
NI
DT
I
Y
G
VV
G
IP
V
TD
M
A
R
H
A
QAE
-
G
-
I
R
Y
I
GF
RHEQ
S
A
GYA
A
A
A
S
G
FLT
Q
K
P
G
I
--
C
LTV
S
A
PG
F
L
N
G
L
T
A
LA
N
A
TV
N
GF
P
M
I
M
ISG
SSDRAI
VDLQ
Q
G
D
YE
E
L
D
QM
--------
NAAKPYA
K
AAF
R
V
NQP
Q
DL
G
IA
L
AR
A
IRV
S
V
S
-
GRPG
G
V
Y
L
DLP
A
N
V
LAATMEKD
---
EALTTIVKVENPS
P
ALLPCPKS
V
TS
A
ISL
L
AK
A
ER
P
L
I
IL
G
K
G
AAY
S
Q
A
DEQ
L
R
E
FIESTQI
P
FLPM
S
M
AK
G
IL
E
DT
HP
---
--
-
-
L
S
A
AAARSFA
L
A
NAD
V
V
ML
VG
A
R
L
NW
L
LAHGKKG
W
A
A
-
D
T
QF
I
Q
L
DI
E
P
Q
EI
DSNRPIA
V
P
V
VGD
IASS
M
QG
M
L
AE
L
KQNTFTT
PL
V
--
--
W
R
D
ILNIH
K
QQNAQKMHEKLST
D
----------------------------
T
-
-QPLNYFNA
L
SA
VRDV
LRENQDIY
L
V
NE
G
AN
T
L
D
N
A
RN
I
IDMYK
PR
RR
L
D
C
G
--------
TW
G
V
MG
I
G
MG
Y
AIGA
SV
T
S
G
S-P
VV
A
IE
GD
S
AFG
F
SGM
E
IE
T
IC
R
YN
LPV
T
IV
IF
NN
G-
-
G
I
Y
R
G
DGVD
L
SGAGAPSPTDLLHH
-----------
AR
Y
DK
L
M
D
A
F
R
GV
G
YN
V
TTTD
E
LRH
AL
TTGIQS
---
RK
P
TI
I
N
V
V
ID
PA
AGTESGHIT
KLN
P
K
Q
VA
G
fig|749545.3.peg.279
Escherichia coli MS 182-1 (13-563/564)
IIV
EA
L
KQN
NI
DT
I
Y
G
VV
G
IP
V
TD
M
A
R
H
A
QAE
-
G
-
I
R
Y
I
GF
RHEQ
S
A
GYA
A
A
A
S
G
FLT
Q
K
P
G
I
--
C
LTV
S
A
PG
F
L
N
G
L
T
A
LA
N
A
TV
N
GF
P
M
I
M
ISG
SSDRAI
VDLQ
Q
G
D
YE
E
L
D
QM
--------
NAAKPYA
K
AAF
R
V
NQP
Q
DL
G
IA
L
AR
A
IRV
S
V
S
-
GRPG
G
V
Y
L
DLP
A
N
V
LAATMEKD
---
EALTTIVKVENPS
P
ALLPCPKS
V
TS
A
ISL
L
AK
A
ER
P
L
I
IL
G
K
G
AAY
S
Q
A
DEQ
L
R
E
FIESTQI
P
FLPM
S
M
AK
G
IL
E
DT
HP
---
--
-
-
L
S
A
AAARSFA
L
A
NAD
V
V
ML
VG
A
R
L
NW
L
LAHGKKG
W
A
A
-
D
T
QF
I
Q
L
DI
E
P
Q
EI
DSNRPIA
V
P
V
VGD
IASS
M
QG
M
L
AE
L
KQNTFTT
PL
V
--
--
W
R
D
ILNIH
K
QQNAQKMHEKLST
D
----------------------------
T
-
-QPLNYFNA
L
SA
VRDV
LRENQDIY
L
V
NE
G
AN
T
L
D
N
A
RN
I
IDMYK
PR
RR
L
D
C
G
--------
TW
G
V
MG
I
G
MG
Y
AIGA
SV
T
S
G
S-P
VV
A
IE
GD
S
AFG
F
SGM
E
IE
T
IC
R
YN
LPV
T
IV
IF
NN
G-
-
G
I
Y
R
G
DGVD
L
SGAGAPSPTDLLHH
-----------
AR
Y
DK
L
M
D
A
F
R
GV
G
YN
V
TTTD
E
LRH
AL
TTGIQS
---
RK
P
TI
I
N
V
V
ID
PA
AGTESGHIT
KLN
P
K
Q
VA
G
fig|749532.3.peg.3136
Escherichia coli MS 78-1 (13-563/564)
IIV
EA
L
KQN
NI
DT
I
Y
G
VV
G
IP
V
TD
M
A
R
H
A
QAE
-
G
-
I
R
Y
I
GF
RHEQ
S
A
GYA
A
A
A
S
G
FLT
Q
K
P
G
I
--
C
LTV
S
A
PG
F
L
N
G
L
T
A
LA
N
A
TV
N
GF
P
M
I
M
ISG
SSDRAI
VDLQ
Q
G
D
YE
E
L
D
QM
--------
NAAKPYA
K
AAF
R
V
NQP
Q
DL
G
IA
L
AR
A
IRV
S
V
S
-
GRPG
G
V
Y
L
DLP
A
N
V
LAATMEKD
---
EALTTIVKVENPS
P
ALLPCPKS
V
TS
A
ISL
L
AK
A
ER
P
L
I
IL
G
K
G
AAY
S
Q
A
DEQ
L
R
E
FIESTQI
P
FLPM
S
M
AK
G
IL
E
DT
HP
---
--
-
-
L
S
A
AAARSFA
L
A
NAD
V
V
ML
VG
A
R
L
NW
L
LAHGKKG
W
A
A
-
D
T
QF
I
Q
L
DI
E
P
Q
EI
DSNRPIA
V
P
V
VGD
IASS
M
QG
M
L
AE
L
KQNTFTT
PL
V
--
--
W
R
D
ILNIH
K
QQNAQKMHEKLST
D
----------------------------
T
-
-QPLNYFNA
L
SA
VRDV
LRENQDIY
L
V
NE
G
AN
T
L
D
N
A
RN
I
IDMYK
PR
RR
L
D
C
G
--------
TW
G
V
MG
I
G
MG
Y
AIGA
SV
T
S
G
S-P
VV
A
IE
GD
S
AFG
F
SGM
E
IE
T
IC
R
YN
LPV
T
IV
IF
NN
G-
-
G
I
Y
R
G
DGVD
L
SGAGAPSPTDLLHH
-----------
AR
Y
DK
L
M
D
A
F
R
GV
G
YN
V
TTTD
E
LRH
AL
TTGIQS
---
RK
P
TI
I
N
V
V
ID
PA
AGTESGHIT
KLN
P
K
Q
VA
G
fig|749533.3.peg.1172
Escherichia coli MS 84-1 (13-563/564)
IIV
EA
L
KQN
NI
DT
I
Y
G
VV
G
IP
V
TD
M
A
R
H
A
QAE
-
G
-
I
R
Y
I
GF
RHEQ
S
A
GYA
A
A
A
S
G
FLT
Q
K
P
G
I
--
C
LTV
S
A
PG
F
L
N
G
L
T
A
LA
N
A
TV
N
GF
P
M
I
M
ISG
SSDRAI
VDLQ
Q
G
D
YE
E
L
D
QM
--------
NAAKPYA
K
AAF
R
V
NQP
Q
DL
G
IA
L
AR
A
IRV
S
V
S
-
GRPG
G
V
Y
L
DLP
A
N
V
LAATMEKD
---
EALTTIVKVENPS
P
ALLPCPKS
V
TS
A
ISL
L
AK
A
ER
P
L
I
IL
G
K
G
AAY
S
Q
A
DEQ
L
R
E
FIESTQI
P
FLPM
S
M
AK
G
IL
E
DT
HP
---
--
-
-
L
S
A
AAARSFA
L
A
NAD
V
V
ML
VG
A
R
L
NW
L
LAHGKKG
W
A
A
-
D
T
QF
I
Q
L
DI
E
P
Q
EI
DSNRPIA
V
P
V
VGD
IASS
M
QG
M
L
AE
L
KQNTFTT
PL
V
--
--
W
R
D
ILNIH
K
QQNAQKMHEKLST
D
----------------------------
T
-
-QPLNYFNA
L
SA
VRDV
LRENQDIY
L
V
NE
G
AN
T
L
D
N
A
RN
I
IDMYK
PR
RR
L
D
C
G
--------
TW
G
V
MG
I
G
MG
Y
AIGA
SV
T
S
G
S-P
VV
A
IE
GD
S
AFG
F
SGM
E
IE
T
IC
R
YN
LPV
T
IV
IF
NN
G-
-
G
I
Y
R
G
DGVD
L
SGAGAPSPTDLLHH
-----------
AR
Y
DK
L
M
D
A
F
R
GV
G
YN
V
TTTD
E
LRH
AL
TTGIQS
---
RK
P
TI
I
N
V
V
ID
PA
AGTESGHIT
KLN
P
K
Q
VA
G
fig|585395.4.peg.3033
Escherichia coli O103:H2 str. 12009 (13-563/564)
IIV
EA
L
KQN
NI
DT
I
Y
G
VV
G
IP
V
TD
M
A
R
H
A
QAE
-
G
-
I
R
Y
I
GF
RHEQ
S
A
GYA
A
A
A
S
G
FLT
Q
K
P
G
I
--
C
LTV
S
A
PG
F
L
N
G
L
T
A
LA
N
A
TV
N
GF
P
M
I
M
ISG
SSDRAI
VDLQ
Q
G
D
YE
E
L
D
QM
--------
NAAKPYA
K
AAF
R
V
NQP
Q
DL
G
IA
L
AR
A
IRV
S
V
S
-
GRPG
G
V
Y
L
DLP
A
N
V
LAATMEKD
---
EALTTIVKVENPS
P
ALLPCPKS
V
TS
A
ISL
L
AK
A
ER
P
L
I
IL
G
K
G
AAY
S
Q
A
DEQ
L
R
E
FIESTQI
P
FLPM
S
M
AK
G
IL
E
DT
HP
---
--
-
-
L
S
A
AAARSFA
L
A
NAD
V
V
ML
VG
A
R
L
NW
L
LAHGKKG
W
A
A
-
D
T
QF
I
Q
L
DI
E
P
Q
EI
DSNRPIA
V
P
V
VGD
IASS
M
QG
M
L
AE
L
KQNTFTT
PL
V
--
--
W
R
D
ILNIH
K
QQNAQKMHEKLST
D
----------------------------
T
-
-QPLNYFNA
L
SA
VRDV
LRENQDIY
L
V
NE
G
AN
T
L
D
N
A
RN
I
IDMYK
PR
RR
L
D
C
G
--------
TW
G
V
MG
I
G
MG
Y
AIGA
SV
T
S
G
S-P
VV
A
IE
GD
S
AFG
F
SGM
E
IE
T
IC
R
YN
LPV
T
IV
IF
NN
G-
-
G
I
Y
R
G
DGVD
L
SGAGAPSPTDLLHH
-----------
AR
Y
DK
L
M
D
A
F
R
GV
G
YN
V
TTTD
E
LRH
AL
TTGIQS
---
RK
P
TI
I
N
V
V
ID
PA
AGTESGHIT
KLN
P
K
Q
VA
G
fig|585396.4.peg.3204
Escherichia coli O111:H- str. 11128 (13-563/564)
IIV
EA
L
KQN
NI
DT
I
Y
G
VV
G
IP
V
TD
M
A
R
H
A
QAE
-
G
-
I
R
Y
I
GF
RHEQ
S
A
GYA
A
A
A
S
G
FLT
Q
K
P
G
I
--
C
LTV
S
A
PG
F
L
N
G
L
T
A
LA
N
A
TV
N
GF
P
M
I
M
ISG
SSDRAI
VDLQ
Q
G
D
YE
E
L
D
QM
--------
NAAKPYA
K
AAF
R
V
NQP
Q
DL
G
IA
L
AR
A
IRV
S
V
S
-
GRPG
G
V
Y
L
DLP
A
N
V
LAATMEKD
---
EALTTIVKVENPS
P
ALLPCPKS
V
TS
A
ISL
L
AK
A
ER
P
L
I
IL
G
K
G
AAY
S
Q
A
DEQ
L
R
E
FIESTQI
P
FLPM
S
M
AK
G
IL
E
DT
HP
---
--
-
-
L
S
A
AAARSFA
L
A
NAD
V
V
ML
VG
A
R
L
NW
L
LAHGKKG
W
A
A
-
D
T
QF
I
Q
L
DI
E
P
Q
EI
DSNRPIA
V
P
V
VGD
IASS
M
QG
M
L
AE
L
KQNTFTT
PL
V
--
--
W
R
D
ILNIH
K
QQNAQKMHEKLST
D
----------------------------
T
-
-QPLNYFNA
L
SA
VRDV
LRENQDIY
L
V
NE
G
AN
T
L
D
N
A
RN
I
IDMYK
PR
RR
L
D
C
G
--------
TW
G
V
MG
I
G
MG
Y
AIGA
SV
T
S
G
S-P
VV
A
IE
GD
S
AFG
F
SGM
E
IE
T
IC
R
YN
LPV
T
IV
IF
NN
G-
-
G
I
Y
R
G
DGVD
L
SGAGAPSPTDLLHH
-----------
AR
Y
DK
L
M
D
A
F
R
GV
G
YN
V
TTTD
E
LRH
AL
TTGIQS
---
RK
P
TI
I
N
V
V
ID
PA
AGTESGHIT
KLN
P
K
Q
VA
G
fig|573235.3.peg.3495
Escherichia coli O26:H11 str. 11368 (13-563/564)
IIV
EA
L
KQN
NI
DT
I
Y
G
VV
G
IP
V
TD
M
A
R
H
A
QAE
-
G
-
I
R
Y
I
GF
RHEQ
S
A
GYA
A
A
A
S
G
FLT
Q
K
P
G
I
--
C
LTV
S
A
PG
F
L
N
G
L
T
A
LA
N
A
TV
N
GF
P
M
I
M
ISG
SSDRAI
VDLQ
Q
G
D
YE
E
L
D
QM
--------
NAAKPYA
K
AAF
R
V
NQP
Q
DL
G
IA
L
AR
A
IRV
S
V
S
-
GRPG
G
V
Y
L
DLP
A
N
V
LAATMEKD
---
EALTTIVKVENPS
P
ALLPCPKS
V
TS
A
ISL
L
AK
A
ER
P
L
I
IL
G
K
G
AAY
S
Q
A
DEQ
L
R
E
FIESTQI
P
FLPM
S
M
AK
G
IL
E
DT
HP
---
--
-
-
L
S
A
AAARSFA
L
A
NAD
V
V
ML
VG
A
R
L
NW
L
LAHGKKG
W
A
A
-
D
T
QF
I
Q
L
DI
E
P
Q
EI
DSNRPIA
V
P
V
VGD
IASS
M
QG
M
L
AE
L
KQNTFTT
PL
V
--
--
W
R
D
ILNIH
K
QQNAQKMHEKLST
D
----------------------------
T
-
-QPLNYFNA
L
SA
VRDV
LRENQDIY
L
V
NE
G
AN
T
L
D
N
A
RN
I
IDMYK
PR
RR
L
D
C
G
--------
TW
G
V
MG
I
G
MG
Y
AIGA
SV
T
S
G
S-P
VV
A
IE
GD
S
AFG
F
SGM
E
IE
T
IC
R
YN
LPV
T
IV
IF
NN
G-
-
G
I
Y
R
G
DGVD
L
SGAGAPSPTDLLHH
-----------
AR
Y
DK
L
M
D
A
F
R
GV
G
YN
V
TTTD
E
LRH
AL
TTGIQS
---
RK
P
TI
I
N
V
V
ID
PA
AGTESGHIT
KLN
P
K
Q
VA
G
fig|409438.11.peg.2833
Escherichia coli SE11 (13-563/564)
IIV
EA
L
KQN
NI
DT
I
Y
G
VV
G
IP
V
TD
M
A
R
H
A
QAE
-
G
-
I
R
Y
I
GF
RHEQ
S
A
GYA
A
A
A
S
G
FLT
Q
K
P
G
I
--
C
LTV
S
A
PG
F
L
N
G
L
T
A
LA
N
A
TV
N
GF
P
M
I
M
ISG
SSDRAI
VDLQ
Q
G
D
YE
E
L
D
QM
--------
NAAKPYA
K
AAF
R
V
NQP
Q
DL
G
IA
L
AR
A
IRV
S
V
S
-
GRPG
G
V
Y
L
DLP
A
N
V
LAATMEKD
---
EALTTIVKVENPS
P
ALLPCPKS
V
TS
A
ISL
L
AK
A
ER
P
L
I
IL
G
K
G
AAY
S
Q
A
DEQ
L
R
E
FIESTQI
P
FLPM
S
M
AK
G
IL
E
DT
HP
---
--
-
-
L
S
A
AAARSFA
L
A
NAD
V
V
ML
VG
A
R
L
NW
L
LAHGKKG
W
A
A
-
D
T
QF
I
Q
L
DI
E
P
Q
EI
DSNRPIA
V
P
V
VGD
IASS
M
QG
M
L
AE
L
KQNTFTT
PL
V
--
--
W
R
D
ILNIH
K
QQNAQKMHEKLST
D
----------------------------
T
-
-QPLNYFNA
L
SA
VRDV
LRENQDIY
L
V
NE
G
AN
T
L
D
N
A
RN
I
IDMYK
PR
RR
L
D
C
G
--------
TW
G
V
MG
I
G
MG
Y
AIGA
SV
T
S
G
S-P
VV
A
IE
GD
S
AFG
F
SGM
E
IE
T
IC
R
YN
LPV
T
IV
IF
NN
G-
-
G
I
Y
R
G
DGVD
L
SGAGAPSPTDLLHH
-----------
AR
Y
DK
L
M
D
A
F
R
GV
G
YN
V
TTTD
E
LRH
AL
TTGIQS
---
RK
P
TI
I
N
V
V
ID
PA
AGTESGHIT
KLN
P
K
Q
VA
G
fig|656443.3.peg.3125
Escherichia coli TA271 (13-563/564)
IIV
EA
L
KQN
NI
DT
I
Y
G
VV
G
IP
V
TD
M
A
R
H
A
QAE
-
G
-
I
R
Y
I
GF
RHEQ
S
A
GYA
A
A
A
S
G
FLT
Q
K
P
G
I
--
C
LTV
S
A
PG
F
L
N
G
L
T
A
LA
N
A
TV
N
GF
P
M
I
M
ISG
SSDRAI
VDLQ
Q
G
D
YE
E
L
D
QM
--------
NAAKPYA
K
AAF
R
V
NQP
Q
DL
G
IA
L
AR
A
IRV
S
V
S
-
GRPG
G
V
Y
L
DLP
A
N
V
LAATMEKD
---
EALTTIVKVENPS
P
ALLPCPKS
V
TS
A
ISL
L
AK
A
ER
P
L
I
IL
G
K
G
AAY
S
Q
A
DEQ
L
R
E
FIESTQI
P
FLPM
S
M
AK
G
IL
E
DT
HP
---
--
-
-
L
S
A
AAARSFA
L
A
NAD
V
V
ML
VG
A
R
L
NW
L
LAHGKKG
W
A
A
-
D
T
QF
I
Q
L
DI
E
P
Q
EI
DSNRPIA
V
P
V
VGD
IASS
M
QG
M
L
AE
L
KQNTFTT
PL
V
--
--
W
R
D
ILNIH
K
QQNAQKMHEKLST
D
----------------------------
T
-
-QPLNYFNA
L
SA
VRDV
LRENQDIY
L
V
NE
G
AN
T
L
D
N
A
RN
I
IDMYK
PR
RR
L
D
C
G
--------
TW
G
V
MG
I
G
MG
Y
AIGA
SV
T
S
G
S-P
VV
A
IE
GD
S
AFG
F
SGM
E
IE
T
IC
R
YN
LPV
T
IV
IF
NN
G-
-
G
I
Y
R
G
DGVD
L
SGAGAPSPTDLLHH
-----------
AR
Y
DK
L
M
D
A
F
R
GV
G
YN
V
TTTD
E
LRH
AL
TTGIQS
---
RK
P
TI
I
N
V
V
ID
PA
AGTESGHIT
KLN
P
K
Q
VA
G
fig|679206.4.peg.736
Escherichia coli MS 119-7 (3-553/554)
IIV
EA
L
KQN
NI
DT
I
Y
G
VV
G
IP
V
TD
M
A
R
H
A
QAE
-
G
-
I
R
Y
I
GF
RHEQ
S
A
GYA
A
A
A
S
G
FLT
Q
K
P
G
I
--
C
LTV
S
A
PG
F
L
N
G
L
T
A
LA
N
A
TV
N
GF
P
M
I
M
ISG
SSDRAI
VDLQ
Q
G
D
YE
E
L
D
QM
--------
NAAKPYA
K
AAF
R
V
NQP
Q
DL
G
IA
L
AR
A
IRV
S
V
S
-
GRPG
G
V
Y
L
DLP
A
N
V
LAATMEKD
---
EALTTIVKVENPS
P
ALLPCPKS
V
TS
A
ISL
L
AK
A
ER
P
L
I
IL
G
K
G
AAY
S
Q
A
DEQ
L
R
E
FIESTQI
P
FLPM
S
M
AK
G
IL
E
DT
HP
---
--
-
-
L
S
A
AAARSFA
L
A
NAD
V
V
ML
VG
A
R
L
NW
L
LAHGKKG
W
A
A
-
D
T
QF
I
Q
L
DI
E
P
Q
EI
DSNRPIA
V
P
V
VGD
IASS
M
QG
M
L
AE
L
KQNTFTT
PL
V
--
--
W
R
D
ILNIH
K
QQNAQKMHEKLST
D
----------------------------
T
-
-QPLNYFNA
L
SA
VRDV
LRENQDIY
L
V
NE
G
AN
T
L
D
N
A
RN
I
IDMYK
PR
RR
L
D
C
G
--------
TW
G
V
MG
I
G
MG
Y
AIGA
SV
T
S
G
S-P
VV
A
IE
GD
S
AFG
F
SGM
E
IE
T
IC
R
YN
LPV
T
IV
IF
NN
G-
-
G
I
Y
R
G
DGVD
L
SGAGAPSPTDLLHH
-----------
AR
Y
DK
L
M
D
A
F
R
GV
G
YN
V
TTTD
E
LRH
AL
TTGIQS
---
RK
P
TI
I
N
V
V
ID
PA
AGTESGHIT
KLN
P
K
Q
VA
G
fig|358709.5.peg.866
Escherichia coli 101-1 (13-563/564)
IIV
EA
L
KQN
NI
DT
I
Y
G
VV
G
IP
V
TD
M
A
R
H
A
QAE
-
G
-
I
R
Y
I
GF
RHEQ
S
A
GYA
A
A
A
S
G
FLT
Q
K
P
G
I
--
C
LTV
S
A
PG
F
L
N
G
L
T
A
LA
N
A
TV
N
GF
P
M
I
M
ISG
SSDRAI
VDLQ
Q
G
D
YE
E
L
D
QM
--------
NAAKPYA
K
AAF
R
V
NQP
Q
DL
G
IA
L
AR
A
IRV
S
V
S
-
GRPG
G
V
Y
L
DLP
A
N
V
LAATMEKD
---
EALTTIVKVENPS
P
ALLPCPKS
V
TS
A
ISL
L
AK
A
ER
P
L
I
IL
G
K
G
AAY
S
Q
A
DEQ
L
R
E
FIESAQI
P
FLPM
S
M
AK
G
IL
E
DT
HP
---
--
-
-
L
S
A
AAARSFA
L
A
NAD
V
V
ML
VG
A
R
L
NW
L
LAHGKKG
W
A
A
-
D
T
QF
I
Q
L
DI
E
P
Q
EI
DSNRPIA
V
P
V
VGD
IASS
M
QG
M
L
AE
L
KQNTFTT
PL
V
--
--
W
R
D
ILNIH
K
QQNAQKMHEKLST
D
----------------------------
T
-
-QPLNYFNA
L
SA
VRDV
LRENQDIY
L
V
NE
G
AN
T
L
D
N
A
RN
I
IDMYK
PR
RR
L
D
C
G
--------
TW
G
V
MG
I
G
MG
Y
AIGA
SV
T
S
G
S-P
VV
A
IE
GD
S
AFG
F
SGM
E
IE
T
IC
R
YN
LPV
T
IV
IF
NN
G-
-
G
I
Y
R
G
DGVD
L
SGAGAPSPTDLLHH
-----------
AR
Y
DK
L
M
D
A
F
R
GV
G
YN
V
TTTD
E
LRH
AL
TTGIQS
---
RK
P
TI
I
N
V
V
ID
PA
AGTESGHIT
KLN
P
K
Q
VA
G
fig|562.371.peg.5244
Escherichia coli 1044A (13-563/564)
IIV
EA
L
KQN
NI
DT
I
Y
G
VV
G
IP
V
TD
M
A
R
H
A
QAE
-
G
-
I
R
Y
I
GF
RHEQ
S
A
GYA
A
A
A
S
G
FLT
Q
K
P
G
I
--
C
LTV
S
A
PG
F
L
N
G
L
T
A
LA
N
A
TV
N
GF
P
M
I
M
ISG
SSDRAI
VDLQ
Q
G
D
YE
E
L
D
QM
--------
NAAKPYA
K
AAF
R
V
NQP
Q
DL
G
IA
L
AR
A
IRV
S
V
S
-
GRPG
G
V
Y
L
DLP
A
N
V
LAATMEKD
---
EALTTIVKVENPS
P
ALLPCPKS
V
TS
A
ISL
L
AK
A
ER
P
L
I
IL
G
K
G
AAY
S
Q
A
DEQ
L
R
E
FIESAQI
P
FLPM
S
M
AK
G
IL
E
DT
HP
---
--
-
-
L
S
A
AAARSFA
L
A
NAD
V
V
ML
VG
A
R
L
NW
L
LAHGKKG
W
A
A
-
D
T
QF
I
Q
L
DI
E
P
Q
EI
DSNRPIA
V
P
V
VGD
IASS
M
QG
M
L
AE
L
KQNTFTT
PL
V
--
--
W
R
D
ILNIH
K
QQNAQKMHEKLST
D
----------------------------
T
-
-QPLNYFNA
L
SA
VRDV
LRENQDIY
L
V
NE
G
AN
T
L
D
N
A
RN
I
IDMYK
PR
RR
L
D
C
G
--------
TW
G
V
MG
I
G
MG
Y
AIGA
SV
T
S
G
S-P
VV
A
IE
GD
S
AFG
F
SGM
E
IE
T
IC
R
YN
LPV
T
IV
IF
NN
G-
-
G
I
Y
R
G
DGVD
L
SGAGAPSPTDLLHH
-----------
AR
Y
DK
L
M
D
A
F
R
GV
G
YN
V
TTTD
E
LRH
AL
TTGIQS
---
RK
P
TI
I
N
V
V
ID
PA
AGTESGHIT
KLN
P
K
Q
VA
G
fig|562.373.peg.3570
Escherichia coli 1125A (13-563/564)
IIV
EA
L
KQN
NI
DT
I
Y
G
VV
G
IP
V
TD
M
A
R
H
A
QAE
-
G
-
I
R
Y
I
GF
RHEQ
S
A
GYA
A
A
A
S
G
FLT
Q
K
P
G
I
--
C
LTV
S
A
PG
F
L
N
G
L
T
A
LA
N
A
TV
N
GF
P
M
I
M
ISG
SSDRAI
VDLQ
Q
G
D
YE
E
L
D
QM
--------
NAAKPYA
K
AAF
R
V
NQP
Q
DL
G
IA
L
AR
A
IRV
S
V
S
-
GRPG
G
V
Y
L
DLP
A
N
V
LAATMEKD
---
EALTTIVKVENPS
P
ALLPCPKS
V
TS
A
ISL
L
AK
A
ER
P
L
I
IL
G
K
G
AAY
S
Q
A
DEQ
L
R
E
FIESAQI
P
FLPM
S
M
AK
G
IL
E
DT
HP
---
--
-
-
L
S
A
AAARSFA
L
A
NAD
V
V
ML
VG
A
R
L
NW
L
LAHGKKG
W
A
A
-
D
T
QF
I
Q
L
DI
E
P
Q
EI
DSNRPIA
V
P
V
VGD
IASS
M
QG
M
L
AE
L
KQNTFTT
PL
V
--
--
W
R
D
ILNIH
K
QQNAQKMHEKLST
D
----------------------------
T
-
-QPLNYFNA
L
SA
VRDV
LRENQDIY
L
V
NE
G
AN
T
L
D
N
A
RN
I
IDMYK
PR
RR
L
D
C
G
--------
TW
G
V
MG
I
G
MG
Y
AIGA
SV
T
S
G
S-P
VV
A
IE
GD
S
AFG
F
SGM
E
IE
T
IC
R
YN
LPV
T
IV
IF
NN
G-
-
G
I
Y
R
G
DGVD
L
SGAGAPSPTDLLHH
-----------
AR
Y
DK
L
M
D
A
F
R
GV
G
YN
V
TTTD
E
LRH
AL
TTGIQS
---
RK
P
TI
I
N
V
V
ID
PA
AGTESGHIT
KLN
P
K
Q
VA
G
fig|562.372.peg.5381
Escherichia coli 1212A (13-563/564)
IIV
EA
L
KQN
NI
DT
I
Y
G
VV
G
IP
V
TD
M
A
R
H
A
QAE
-
G
-
I
R
Y
I
GF
RHEQ
S
A
GYA
A
A
A
S
G
FLT
Q
K
P
G
I
--
C
LTV
S
A
PG
F
L
N
G
L
T
A
LA
N
A
TV
N
GF
P
M
I
M
ISG
SSDRAI
VDLQ
Q
G
D
YE
E
L
D
QM
--------
NAAKPYA
K
AAF
R
V
NQP
Q
DL
G
IA
L
AR
A
IRV
S
V
S
-
GRPG
G
V
Y
L
DLP
A
N
V
LAATMEKD
---
EALTTIVKVENPS
P
ALLPCPKS
V
TS
A
ISL
L
AK
A
ER
P
L
I
IL
G
K
G
AAY
S
Q
A
DEQ
L
R
E
FIESAQI
P
FLPM
S
M
AK
G
IL
E
DT
HP
---
--
-
-
L
S
A
AAARSFA
L
A
NAD
V
V
ML
VG
A
R
L
NW
L
LAHGKKG
W
A
A
-
D
T
QF
I
Q
L
DI
E
P
Q
EI
DSNRPIA
V
P
V
VGD
IASS
M
QG
M
L
AE
L
KQNTFTT
PL
V
--
--
W
R
D
ILNIH
K
QQNAQKMHEKLST
D
----------------------------
T
-
-QPLNYFNA
L
SA
VRDV
LRENQDIY
L
V
NE
G
AN
T
L
D
N
A
RN
I
IDMYK
PR
RR
L
D
C
G
--------
TW
G
V
MG
I
G
MG
Y
AIGA
SV
T
S
G
S-P
VV
A
IE
GD
S
AFG
F
SGM
E
IE
T
IC
R
YN
LPV
T
IV
IF
NN
G-
-
G
I
Y
R
G
DGVD
L
SGAGAPSPTDLLHH
-----------
AR
Y
DK
L
M
D
A
F
R
GV
G
YN
V
TTTD
E
LRH
AL
TTGIQS
---
RK
P
TI
I
N
V
V
ID
PA
AGTESGHIT
KLN
P
K
Q
VA
G
fig|562.374.peg.837
Escherichia coli 536A (13-563/564)
IIV
EA
L
KQN
NI
DT
I
Y
G
VV
G
IP
V
TD
M
A
R
H
A
QAE
-
G
-
I
R
Y
I
GF
RHEQ
S
A
GYA
A
A
A
S
G
FLT
Q
K
P
G
I
--
C
LTV
S
A
PG
F
L
N
G
L
T
A
LA
N
A
TV
N
GF
P
M
I
M
ISG
SSDRAI
VDLQ
Q
G
D
YE
E
L
D
QM
--------
NAAKPYA
K
AAF
R
V
NQP
Q
DL
G
IA
L
AR
A
IRV
S
V
S
-
GRPG
G
V
Y
L
DLP
A
N
V
LAATMEKD
---
EALTTIVKVENPS
P
ALLPCPKS
V
TS
A
ISL
L
AK
A
ER
P
L
I
IL
G
K
G
AAY
S
Q
A
DEQ
L
R
E
FIESAQI
P
FLPM
S
M
AK
G
IL
E
DT
HP
---
--
-
-
L
S
A
AAARSFA
L
A
NAD
V
V
ML
VG
A
R
L
NW
L
LAHGKKG
W
A
A
-
D
T
QF
I
Q
L
DI
E
P
Q
EI
DSNRPIA
V
P
V
VGD
IASS
M
QG
M
L
AE
L
KQNTFTT
PL
V
--
--
W
R
D
ILNIH
K
QQNAQKMHEKLST
D
----------------------------
T
-
-QPLNYFNA
L
SA
VRDV
LRENQDIY
L
V
NE
G
AN
T
L
D
N
A
RN
I
IDMYK
PR
RR
L
D
C
G
--------
TW
G
V
MG
I
G
MG
Y
AIGA
SV
T
S
G
S-P
VV
A
IE
GD
S
AFG
F
SGM
E
IE
T
IC
R
YN
LPV
T
IV
IF
NN
G-
-
G
I
Y
R
G
DGVD
L
SGAGAPSPTDLLHH
-----------
AR
Y
DK
L
M
D
A
F
R
GV
G
YN
V
TTTD
E
LRH
AL
TTGIQS
---
RK
P
TI
I
N
V
V
ID
PA
AGTESGHIT
KLN
P
K
Q
VA
G
fig|413997.3.peg.2387
Escherichia coli B str. REL606 (13-563/564)
IIV
EA
L
KQN
NI
DT
I
Y
G
VV
G
IP
V
TD
M
A
R
H
A
QAE
-
G
-
I
R
Y
I
GF
RHEQ
S
A
GYA
A
A
A
S
G
FLT
Q
K
P
G
I
--
C
LTV
S
A
PG
F
L
N
G
L
T
A
LA
N
A
TV
N
GF
P
M
I
M
ISG
SSDRAI
VDLQ
Q
G
D
YE
E
L
D
QM
--------
NAAKPYA
K
AAF
R
V
NQP
Q
DL
G
IA
L
AR
A
IRV
S
V
S
-
GRPG
G
V
Y
L
DLP
A
N
V
LAATMEKD
---
EALTTIVKVENPS
P
ALLPCPKS
V
TS
A
ISL
L
AK
A
ER
P
L
I
IL
G
K
G
AAY
S
Q
A
DEQ
L
R
E
FIESAQI
P
FLPM
S
M
AK
G
IL
E
DT
HP
---
--
-
-
L
S
A
AAARSFA
L
A
NAD
V
V
ML
VG
A
R
L
NW
L
LAHGKKG
W
A
A
-
D
T
QF
I
Q
L
DI
E
P
Q
EI
DSNRPIA
V
P
V
VGD
IASS
M
QG
M
L
AE
L
KQNTFTT
PL
V
--
--
W
R
D
ILNIH
K
QQNAQKMHEKLST
D
----------------------------
T
-
-QPLNYFNA
L
SA
VRDV
LRENQDIY
L
V
NE
G
AN
T
L
D
N
A
RN
I
IDMYK
PR
RR
L
D
C
G
--------
TW
G
V
MG
I
G
MG
Y
AIGA
SV
T
S
G
S-P
VV
A
IE
GD
S
AFG
F
SGM
E
IE
T
IC
R
YN
LPV
T
IV
IF
NN
G-
-
G
I
Y
R
G
DGVD
L
SGAGAPSPTDLLHH
-----------
AR
Y
DK
L
M
D
A
F
R
GV
G
YN
V
TTTD
E
LRH
AL
TTGIQS
---
RK
P
TI
I
N
V
V
ID
PA
AGTESGHIT
KLN
P
K
Q
VA
G
fig|469008.4.peg.1336
Escherichia coli BL21(DE3) (13-563/564)
IIV
EA
L
KQN
NI
DT
I
Y
G
VV
G
IP
V
TD
M
A
R
H
A
QAE
-
G
-
I
R
Y
I
GF
RHEQ
S
A
GYA
A
A
A
S
G
FLT
Q
K
P
G
I
--
C
LTV
S
A
PG
F
L
N
G
L
T
A
LA
N
A
TV
N
GF
P
M
I
M
ISG
SSDRAI
VDLQ
Q
G
D
YE
E
L
D
QM
--------
NAAKPYA
K
AAF
R
V
NQP
Q
DL
G
IA
L
AR
A
IRV
S
V
S
-
GRPG
G
V
Y
L
DLP
A
N
V
LAATMEKD
---
EALTTIVKVENPS
P
ALLPCPKS
V
TS
A
ISL
L
AK
A
ER
P
L
I
IL
G
K
G
AAY
S
Q
A
DEQ
L
R
E
FIESAQI
P
FLPM
S
M
AK
G
IL
E
DT
HP
---
--
-
-
L
S
A
AAARSFA
L
A
NAD
V
V
ML
VG
A
R
L
NW
L
LAHGKKG
W
A
A
-
D
T
QF
I
Q
L
DI
E
P
Q
EI
DSNRPIA
V
P
V
VGD
IASS
M
QG
M
L
AE
L
KQNTFTT
PL
V
--
--
W
R
D
ILNIH
K
QQNAQKMHEKLST
D
----------------------------
T
-
-QPLNYFNA
L
SA
VRDV
LRENQDIY
L
V
NE
G
AN
T
L
D
N
A
RN
I
IDMYK
PR
RR
L
D
C
G
--------
TW
G
V
MG
I
G
MG
Y
AIGA
SV
T
S
G
S-P
VV
A
IE
GD
S
AFG
F
SGM
E
IE
T
IC
R
YN
LPV
T
IV
IF
NN
G-
-
G
I
Y
R
G
DGVD
L
SGAGAPSPTDLLHH
-----------
AR
Y
DK
L
M
D
A
F
R
GV
G
YN
V
TTTD
E
LRH
AL
TTGIQS
---
RK
P
TI
I
N
V
V
ID
PA
AGTESGHIT
KLN
P
K
Q
VA
G
fig|595496.3.peg.2352
Escherichia coli BW2952 (13-563/564)
IIV
EA
L
KQN
NI
DT
I
Y
G
VV
G
IP
V
TD
M
A
R
H
A
QAE
-
G
-
I
R
Y
I
GF
RHEQ
S
A
GYA
A
A
A
S
G
FLT
Q
K
P
G
I
--
C
LTV
S
A
PG
F
L
N
G
L
T
A
LA
N
A
TV
N
GF
P
M
I
M
ISG
SSDRAI
VDLQ
Q
G
D
YE
E
L
D
QM
--------
NAAKPYA
K
AAF
R
V
NQP
Q
DL
G
IA
L
AR
A
IRV
S
V
S
-
GRPG
G
V
Y
L
DLP
A
N
V
LAATMEKD
---
EALTTIVKVENPS
P
ALLPCPKS
V
TS
A
ISL
L
AK
A
ER
P
L
I
IL
G
K
G
AAY
S
Q
A
DEQ
L
R
E
FIESAQI
P
FLPM
S
M
AK
G
IL
E
DT
HP
---
--
-
-
L
S
A
AAARSFA
L
A
NAD
V
V
ML
VG
A
R
L
NW
L
LAHGKKG
W
A
A
-
D
T
QF
I
Q
L
DI
E
P
Q
EI
DSNRPIA
V
P
V
VGD
IASS
M
QG
M
L
AE
L
KQNTFTT
PL
V
--
--
W
R
D
ILNIH
K
QQNAQKMHEKLST
D
----------------------------
T
-
-QPLNYFNA
L
SA
VRDV
LRENQDIY
L
V
NE
G
AN
T
L
D
N
A
RN
I
IDMYK
PR
RR
L
D
C
G
--------
TW
G
V
MG
I
G
MG
Y
AIGA
SV
T
S
G
S-P
VV
A
IE
GD
S
AFG
F
SGM
E
IE
T
IC
R
YN
LPV
T
IV
IF
NN
G-
-
G
I
Y
R
G
DGVD
L
SGAGAPSPTDLLHH
-----------
AR
Y
DK
L
M
D
A
F
R
GV
G
YN
V
TTTD
E
LRH
AL
TTGIQS
---
RK
P
TI
I
N
V
V
ID
PA
AGTESGHIT
KLN
P
K
Q
VA
G
fig|536056.3.peg.1349
Escherichia coli DH1 (13-563/564)
IIV
EA
L
KQN
NI
DT
I
Y
G
VV
G
IP
V
TD
M
A
R
H
A
QAE
-
G
-
I
R
Y
I
GF
RHEQ
S
A
GYA
A
A
A
S
G
FLT
Q
K
P
G
I
--
C
LTV
S
A
PG
F
L
N
G
L
T
A
LA
N
A
TV
N
GF
P
M
I
M
ISG
SSDRAI
VDLQ
Q
G
D
YE
E
L
D
QM
--------
NAAKPYA
K
AAF
R
V
NQP
Q
DL
G
IA
L
AR
A
IRV
S
V
S
-
GRPG
G
V
Y
L
DLP
A
N
V
LAATMEKD
---
EALTTIVKVENPS
P
ALLPCPKS
V
TS
A
ISL
L
AK
A
ER
P
L
I
IL
G
K
G
AAY
S
Q
A
DEQ
L
R
E
FIESAQI
P
FLPM
S
M
AK
G
IL
E
DT
HP
---
--
-
-
L
S
A
AAARSFA
L
A
NAD
V
V
ML
VG
A
R
L
NW
L
LAHGKKG
W
A
A
-
D
T
QF
I
Q
L
DI
E
P
Q
EI
DSNRPIA
V
P
V
VGD
IASS
M
QG
M
L
AE
L
KQNTFTT
PL
V
--
--
W
R
D
ILNIH
K
QQNAQKMHEKLST
D
----------------------------
T
-
-QPLNYFNA
L
SA
VRDV
LRENQDIY
L
V
NE
G
AN
T
L
D
N
A
RN
I
IDMYK
PR
RR
L
D
C
G
--------
TW
G
V
MG
I
G
MG
Y
AIGA
SV
T
S
G
S-P
VV
A
IE
GD
S
AFG
F
SGM
E
IE
T
IC
R
YN
LPV
T
IV
IF
NN
G-
-
G
I
Y
R
G
DGVD
L
SGAGAPSPTDLLHH
-----------
AR
Y
DK
L
M
D
A
F
R
GV
G
YN
V
TTTD
E
LRH
AL
TTGIQS
---
RK
P
TI
I
N
V
V
ID
PA
AGTESGHIT
KLN
P
K
Q
VA
G
fig|316401.4.peg.2847
Escherichia coli ETEC H10407 (13-563/564)
IIV
EA
L
KQN
NI
DT
I
Y
G
VV
G
IP
V
TD
M
A
R
H
A
QAE
-
G
-
I
R
Y
I
GF
RHEQ
S
A
GYA
A
A
A
S
G
FLT
Q
K
P
G
I
--
C
LTV
S
A
PG
F
L
N
G
L
T
A
LA
N
A
TV
N
GF
P
M
I
M
ISG
SSDRAI
VDLQ
Q
G
D
YE
E
L
D
QM
--------
NAAKPYA
K
AAF
R
V
NQP
Q
DL
G
IA
L
AR
A
IRV
S
V
S
-
GRPG
G
V
Y
L
DLP
A
N
V
LAATMEKD
---
EALTTIVKVENPS
P
ALLPCPKS
V
TS
A
ISL
L
AK
A
ER
P
L
I
IL
G
K
G
AAY
S
Q
A
DEQ
L
R
E
FIESAQI
P
FLPM
S
M
AK
G
IL
E
DT
HP
---
--
-
-
L
S
A
AAARSFA
L
A
NAD
V
V
ML
VG
A
R
L
NW
L
LAHGKKG
W
A
A
-
D
T
QF
I
Q
L
DI
E
P
Q
EI
DSNRPIA
V
P
V
VGD
IASS
M
QG
M
L
AE
L
KQNTFTT
PL
V
--
--
W
R
D
ILNIH
K
QQNAQKMHEKLST
D
----------------------------
T
-
-QPLNYFNA
L
SA
VRDV
LRENQDIY
L
V
NE
G
AN
T
L
D
N
A
RN
I
IDMYK
PR
RR
L
D
C
G
--------
TW
G
V
MG
I
G
MG
Y
AIGA
SV
T
S
G
S-P
VV
A
IE
GD
S
AFG
F
SGM
E
IE
T
IC
R
YN
LPV
T
IV
IF
NN
G-
-
G
I
Y
R
G
DGVD
L
SGAGAPSPTDLLHH
-----------
AR
Y
DK
L
M
D
A
F
R
GV
G
YN
V
TTTD
E
LRH
AL
TTGIQS
---
RK
P
TI
I
N
V
V
ID
PA
AGTESGHIT
KLN
P
K
Q
VA
G
fig|656414.3.peg.2746
Escherichia coli H736 (13-563/564)
IIV
EA
L
KQN
NI
DT
I
Y
G
VV
G
IP
V
TD
M
A
R
H
A
QAE
-
G
-
I
R
Y
I
GF
RHEQ
S
A
GYA
A
A
A
S
G
FLT
Q
K
P
G
I
--
C
LTV
S
A
PG
F
L
N
G
L
T
A
LA
N
A
TV
N
GF
P
M
I
M
ISG
SSDRAI
VDLQ
Q
G
D
YE
E
L
D
QM
--------
NAAKPYA
K
AAF
R
V
NQP
Q
DL
G
IA
L
AR
A
IRV
S
V
S
-
GRPG
G
V
Y
L
DLP
A
N
V
LAATMEKD
---
EALTTIVKVENPS
P
ALLPCPKS
V
TS
A
ISL
L
AK
A
ER
P
L
I
IL
G
K
G
AAY
S
Q
A
DEQ
L
R
E
FIESAQI
P
FLPM
S
M
AK
G
IL
E
DT
HP
---
--
-
-
L
S
A
AAARSFA
L
A
NAD
V
V
ML
VG
A
R
L
NW
L
LAHGKKG
W
A
A
-
D
T
QF
I
Q
L
DI
E
P
Q
EI
DSNRPIA
V
P
V
VGD
IASS
M
QG
M
L
AE
L
KQNTFTT
PL
V
--
--
W
R
D
ILNIH
K
QQNAQKMHEKLST
D
----------------------------
T
-
-QPLNYFNA
L
SA
VRDV
LRENQDIY
L
V
NE
G
AN
T
L
D
N
A
RN
I
IDMYK
PR
RR
L
D
C
G
--------
TW
G
V
MG
I
G
MG
Y
AIGA
SV
T
S
G
S-P
VV
A
IE
GD
S
AFG
F
SGM
E
IE
T
IC
R
YN
LPV
T
IV
IF
NN
G-
-
G
I
Y
R
G
DGVD
L
SGAGAPSPTDLLHH
-----------
AR
Y
DK
L
M
D
A
F
R
GV
G
YN
V
TTTD
E
LRH
AL
TTGIQS
---
RK
P
TI
I
N
V
V
ID
PA
AGTESGHIT
KLN
P
K
Q
VA
G
fig|331112.3.peg.2356
Escherichia coli HS (13-563/564)
IIV
EA
L
KQN
NI
DT
I
Y
G
VV
G
IP
V
TD
M
A
R
H
A
QAE
-
G
-
I
R
Y
I
GF
RHEQ
S
A
GYA
A
A
A
S
G
FLT
Q
K
P
G
I
--
C
LTV
S
A
PG
F
L
N
G
L
T
A
LA
N
A
TV
N
GF
P
M
I
M
ISG
SSDRAI
VDLQ
Q
G
D
YE
E
L
D
QM
--------
NAAKPYA
K
AAF
R
V
NQP
Q
DL
G
IA
L
AR
A
IRV
S
V
S
-
GRPG
G
V
Y
L
DLP
A
N
V
LAATMEKD
---
EALTTIVKVENPS
P
ALLPCPKS
V
TS
A
ISL
L
AK
A
ER
P
L
I
IL
G
K
G
AAY
S
Q
A
DEQ
L
R
E
FIESAQI
P
FLPM
S
M
AK
G
IL
E
DT
HP
---
--
-
-
L
S
A
AAARSFA
L
A
NAD
V
V
ML
VG
A
R
L
NW
L
LAHGKKG
W
A
A
-
D
T
QF
I
Q
L
DI
E
P
Q
EI
DSNRPIA
V
P
V
VGD
IASS
M
QG
M
L
AE
L
KQNTFTT
PL
V
--
--
W
R
D
ILNIH
K
QQNAQKMHEKLST
D
----------------------------
T
-
-QPLNYFNA
L
SA
VRDV
LRENQDIY
L
V
NE
G
AN
T
L
D
N
A
RN
I
IDMYK
PR
RR
L
D
C
G
--------
TW
G
V
MG
I
G
MG
Y
AIGA
SV
T
S
G
S-P
VV
A
IE
GD
S
AFG
F
SGM
E
IE
T
IC
R
YN
LPV
T
IV
IF
NN
G-
-
G
I
Y
R
G
DGVD
L
SGAGAPSPTDLLHH
-----------
AR
Y
DK
L
M
D
A
F
R
GV
G
YN
V
TTTD
E
LRH
AL
TTGIQS
---
RK
P
TI
I
N
V
V
ID
PA
AGTESGHIT
KLN
P
K
Q
VA
G
fig|331112.6.peg.2460
Escherichia coli HS (13-563/564)
IIV
EA
L
KQN
NI
DT
I
Y
G
VV
G
IP
V
TD
M
A
R
H
A
QAE
-
G
-
I
R
Y
I
GF
RHEQ
S
A
GYA
A
A
A
S
G
FLT
Q
K
P
G
I
--
C
LTV
S
A
PG
F
L
N
G
L
T
A
LA
N
A
TV
N
GF
P
M
I
M
ISG
SSDRAI
VDLQ
Q
G
D
YE
E
L
D
QM
--------
NAAKPYA
K
AAF
R
V
NQP
Q
DL
G
IA
L
AR
A
IRV
S
V
S
-
GRPG
G
V
Y
L
DLP
A
N
V
LAATMEKD
---
EALTTIVKVENPS
P
ALLPCPKS
V
TS
A
ISL
L
AK
A
ER
P
L
I
IL
G
K
G
AAY
S
Q
A
DEQ
L
R
E
FIESAQI
P
FLPM
S
M
AK
G
IL
E
DT
HP
---
--
-
-
L
S
A
AAARSFA
L
A
NAD
V
V
ML
VG
A
R
L
NW
L
LAHGKKG
W
A
A
-
D
T
QF
I
Q
L
DI
E
P
Q
EI
DSNRPIA
V
P
V
VGD
IASS
M
QG
M
L
AE
L
KQNTFTT
PL
V
--
--
W
R
D
ILNIH
K
QQNAQKMHEKLST
D
----------------------------
T
-
-QPLNYFNA
L
SA
VRDV
LRENQDIY
L
V
NE
G
AN
T
L
D
N
A
RN
I
IDMYK
PR
RR
L
D
C
G
--------
TW
G
V
MG
I
G
MG
Y
AIGA
SV
T
S
G
S-P
VV
A
IE
GD
S
AFG
F
SGM
E
IE
T
IC
R
YN
LPV
T
IV
IF
NN
G-
-
G
I
Y
R
G
DGVD
L
SGAGAPSPTDLLHH
-----------
AR
Y
DK
L
M
D
A
F
R
GV
G
YN
V
TTTD
E
LRH
AL
TTGIQS
---
RK
P
TI
I
N
V
V
ID
PA
AGTESGHIT
KLN
P
K
Q
VA
G
fig|83333.1.peg.2346
Escherichia coli K12 (13-563/564)
IIV
EA
L
KQN
NI
DT
I
Y
G
VV
G
IP
V
TD
M
A
R
H
A
QAE
-
G
-
I
R
Y
I
GF
RHEQ
S
A
GYA
A
A
A
S
G
FLT
Q
K
P
G
I
--
C
LTV
S
A
PG
F
L
N
G
L
T
A
LA
N
A
TV
N
GF
P
M
I
M
ISG
SSDRAI
VDLQ
Q
G
D
YE
E
L
D
QM
--------
NAAKPYA
K
AAF
R
V
NQP
Q
DL
G
IA
L
AR
A
IRV
S
V
S
-
GRPG
G
V
Y
L
DLP
A
N
V
LAATMEKD
---
EALTTIVKVENPS
P
ALLPCPKS
V
TS
A
ISL
L
AK
A
ER
P
L
I
IL
G
K
G
AAY
S
Q
A
DEQ
L
R
E
FIESAQI
P
FLPM
S
M
AK
G
IL
E
DT
HP
---
--
-
-
L
S
A
AAARSFA
L
A
NAD
V
V
ML
VG
A
R
L
NW
L
LAHGKKG
W
A
A
-
D
T
QF
I
Q
L
DI
E
P
Q
EI
DSNRPIA
V
P
V
VGD
IASS
M
QG
M
L
AE
L
KQNTFTT
PL
V
--
--
W
R
D
ILNIH
K
QQNAQKMHEKLST
D
----------------------------
T
-
-QPLNYFNA
L
SA
VRDV
LRENQDIY
L
V
NE
G
AN
T
L
D
N
A
RN
I
IDMYK
PR
RR
L
D
C
G
--------
TW
G
V
MG
I
G
MG
Y
AIGA
SV
T
S
G
S-P
VV
A
IE
GD
S
AFG
F
SGM
E
IE
T
IC
R
YN
LPV
T
IV
IF
NN
G-
-
G
I
Y
R
G
DGVD
L
SGAGAPSPTDLLHH
-----------
AR
Y
DK
L
M
D
A
F
R
GV
G
YN
V
TTTD
E
LRH
AL
TTGIQS
---
RK
P
TI
I
N
V
V
ID
PA
AGTESGHIT
KLN
P
K
Q
VA
G
fig|595495.4.peg.24
Escherichia coli KO11 (13-563/564)
IIV
EA
L
KQN
NI
DT
I
Y
G
VV
G
IP
V
TD
M
A
R
H
A
QAE
-
G
-
I
R
Y
I
GF
RHEQ
S
A
GYA
A
A
A
S
G
FLT
Q
K
P
G
I
--
C
LTV
S
A
PG
F
L
N
G
L
T
A
LA
N
A
TV
N
GF
P
M
I
M
ISG
SSDRAI
VDLQ
Q
G
D
YE
E
L
D
QM
--------
NAAKPYA
K
AAF
R
V
NQP
Q
DL
G
IA
L
AR
A
IRV
S
V
S
-
GRPG
G
V
Y
L
DLP
A
N
V
LAATMEKD
---
EALTTIVKVENPS
P
ALLPCPKS
V
TS
A
ISL
L
AK
A
ER
P
L
I
IL
G
K
G
AAY
S
Q
A
DEQ
L
R
E
FIESAQI
P
FLPM
S
M
AK
G
IL
E
DT
HP
---
--
-
-
L
S
A
AAARSFA
L
A
NAD
V
V
ML
VG
A
R
L
NW
L
LAHGKKG
W
A
A
-
D
T
QF
I
Q
L
DI
E
P
Q
EI
DSNRPIA
V
P
V
VGD
IASS
M
QG
M
L
AE
L
KQNTFTT
PL
V
--
--
W
R
D
ILNIH
K
QQNAQKMHEKLST
D
----------------------------
T
-
-QPLNYFNA
L
SA
VRDV
LRENQDIY
L
V
NE
G
AN
T
L
D
N
A
RN
I
IDMYK
PR
RR
L
D
C
G
--------
TW
G
V
MG
I
G
MG
Y
AIGA
SV
T
S
G
S-P
VV
A
IE
GD
S
AFG
F
SGM
E
IE
T
IC
R
YN
LPV
T
IV
IF
NN
G-
-
G
I
Y
R
G
DGVD
L
SGAGAPSPTDLLHH
-----------
AR
Y
DK
L
M
D
A
F
R
GV
G
YN
V
TTTD
E
LRH
AL
TTGIQS
---
RK
P
TI
I
N
V
V
ID
PA
AGTESGHIT
KLN
P
K
Q
VA
G
fig|749540.3.peg.3879
Escherichia coli MS 146-1 (13-563/564)
IIV
EA
L
KQN
NI
DT
I
Y
G
VV
G
IP
V
TD
M
A
R
H
A
QAE
-
G
-
I
R
Y
I
GF
RHEQ
S
A
GYA
A
A
A
S
G
FLT
Q
K
P
G
I
--
C
LTV
S
A
PG
F
L
N
G
L
T
A
LA
N
A
TV
N
GF
P
M
I
M
ISG
SSDRAI
VDLQ
Q
G
D
YE
E
L
D
QM
--------
NAAKPYA
K
AAF
R
V
NQP
Q
DL
G
IA
L
AR
A
IRV
S
V
S
-
GRPG
G
V
Y
L
DLP
A
N
V
LAATMEKD
---
EALTTIVKVENPS
P
ALLPCPKS
V
TS
A
ISL
L
AK
A
ER
P
L
I
IL
G
K
G
AAY
S
Q
A
DEQ
L
R
E
FIESAQI
P
FLPM
S
M
AK
G
IL
E
DT
HP
---
--
-
-
L
S
A
AAARSFA
L
A
NAD
V
V
ML
VG
A
R
L
NW
L
LAHGKKG
W
A
A
-
D
T
QF
I
Q
L
DI
E
P
Q
EI
DSNRPIA
V
P
V
VGD
IASS
M
QG
M
L
AE
L
KQNTFTT
PL
V
--
--
W
R
D
ILNIH
K
QQNAQKMHEKLST
D
----------------------------
T
-
-QPLNYFNA
L
SA
VRDV
LRENQDIY
L
V
NE
G
AN
T
L
D
N
A
RN
I
IDMYK
PR
RR
L
D
C
G
--------
TW
G
V
MG
I
G
MG
Y
AIGA
SV
T
S
G
S-P
VV
A
IE
GD
S
AFG
F
SGM
E
IE
T
IC
R
YN
LPV
T
IV
IF
NN
G-
-
G
I
Y
R
G
DGVD
L
SGAGAPSPTDLLHH
-----------
AR
Y
DK
L
M
D
A
F
R
GV
G
YN
V
TTTD
E
LRH
AL
TTGIQS
---
RK
P
TI
I
N
V
V
ID
PA
AGTESGHIT
KLN
P
K
Q
VA
G
fig|749547.3.peg.868
Escherichia coli MS 187-1 (13-563/564)
IIV
EA
L
KQN
NI
DT
I
Y
G
VV
G
IP
V
TD
M
A
R
H
A
QAE
-
G
-
I
R
Y
I
GF
RHEQ
S
A
GYA
A
A
A
S
G
FLT
Q
K
P
G
I
--
C
LTV
S
A
PG
F
L
N
G
L
T
A
LA
N
A
TV
N
GF
P
M
I
M
ISG
SSDRAI
VDLQ
Q
G
D
YE
E
L
D
QM
--------
NAAKPYA
K
AAF
R
V
NQP
Q
DL
G
IA
L
AR
A
IRV
S
V
S
-
GRPG
G
V
Y
L
DLP
A
N
V
LAATMEKD
---
EALTTIVKVENPS
P
ALLPCPKS
V
TS
A
ISL
L
AK
A
ER
P
L
I
IL
G
K
G
AAY
S
Q
A
DEQ
L
R
E
FIESAQI
P
FLPM
S
M
AK
G
IL
E
DT
HP
---
--
-
-
L
S
A
AAARSFA
L
A
NAD
V
V
ML
VG
A
R
L
NW
L
LAHGKKG
W
A
A
-
D
T
QF
I
Q
L
DI
E
P
Q
EI
DSNRPIA
V
P
V
VGD
IASS
M
QG
M
L
AE
L
KQNTFTT
PL
V
--
--
W
R
D
ILNIH
K
QQNAQKMHEKLST
D
----------------------------
T
-
-QPLNYFNA
L
SA
VRDV
LRENQDIY
L
V
NE
G
AN
T
L
D
N
A
RN
I
IDMYK
PR
RR
L
D
C
G
--------
TW
G
V
MG
I
G
MG
Y
AIGA
SV
T
S
G
S-P
VV
A
IE
GD
S
AFG
F
SGM
E
IE
T
IC
R
YN
LPV
T
IV
IF
NN
G-
-
G
I
Y
R
G
DGVD
L
SGAGAPSPTDLLHH
-----------
AR
Y
DK
L
M
D
A
F
R
GV
G
YN
V
TTTD
E
LRH
AL
TTGIQS
---
RK
P
TI
I
N
V
V
ID
PA
AGTESGHIT
KLN
P
K
Q
VA
G
fig|749548.3.peg.1903
Escherichia coli MS 196-1 (13-563/564)
IIV
EA
L
KQN
NI
DT
I
Y
G
VV
G
IP
V
TD
M
A
R
H
A
QAE
-
G
-
I
R
Y
I
GF
RHEQ
S
A
GYA
A
A
A
S
G
FLT
Q
K
P
G
I
--
C
LTV
S
A
PG
F
L
N
G
L
T
A
LA
N
A
TV
N
GF
P
M
I
M
ISG
SSDRAI
VDLQ
Q
G
D
YE
E
L
D
QM
--------
NAAKPYA
K
AAF
R
V
NQP
Q
DL
G
IA
L
AR
A
IRV
S
V
S
-
GRPG
G
V
Y
L
DLP
A
N
V
LAATMEKD
---
EALTTIVKVENPS
P
ALLPCPKS
V
TS
A
ISL
L
AK
A
ER
P
L
I
IL
G
K
G
AAY
S
Q
A
DEQ
L
R
E
FIESAQI
P
FLPM
S
M
AK
G
IL
E
DT
HP
---
--
-
-
L
S
A
AAARSFA
L
A
NAD
V
V
ML
VG
A
R
L
NW
L
LAHGKKG
W
A
A
-
D
T
QF
I
Q
L
DI
E
P
Q
EI
DSNRPIA
V
P
V
VGD
IASS
M
QG
M
L
AE
L
KQNTFTT
PL
V
--
--
W
R
D
ILNIH
K
QQNAQKMHEKLST
D
----------------------------
T
-
-QPLNYFNA
L
SA
VRDV
LRENQDIY
L
V
NE
G
AN
T
L
D
N
A
RN
I
IDMYK
PR
RR
L
D
C
G
--------
TW
G
V
MG
I
G
MG
Y
AIGA
SV
T
S
G
S-P
VV
A
IE
GD
S
AFG
F
SGM
E
IE
T
IC
R
YN
LPV
T
IV
IF
NN
G-
-
G
I
Y
R
G
DGVD
L
SGAGAPSPTDLLHH
-----------
AR
Y
DK
L
M
D
A
F
R
GV
G
YN
V
TTTD
E
LRH
AL
TTGIQS
---
RK
P
TI
I
N
V
V
ID
PA
AGTESGHIT
KLN
P
K
Q
VA
G
fig|83334.1.peg.3249
Escherichia coli O157:H7 (13-563/564)
IIV
EA
L
KQN
NI
DT
I
Y
G
VV
G
IP
V
TD
M
A
R
H
A
QAE
-
G
-
I
R
Y
I
GF
RHEQ
S
A
GYA
A
A
A
S
G
FLT
Q
K
P
G
I
--
C
LTV
S
A
PG
F
L
N
G
L
T
A
LA
N
A
TV
N
GF
P
M
I
M
ISG
SSDRAI
VDLQ
Q
G
D
YE
E
L
D
QM
--------
NAAKPYA
K
AAF
R
V
NQP
Q
DL
G
IA
L
AR
A
IRV
S
V
S
-
GRPG
G
V
Y
L
DLP
A
N
V
LAATMEKD
---
EALTTIVKVENPS
P
ALLPCPKS
V
TS
A
ISL
L
AK
A
ER
P
L
I
IL
G
K
G
AAY
S
Q
A
DEQ
L
R
E
FIESAQI
P
FLPM
S
M
AK
G
IL
E
DT
HP
---
--
-
-
L
S
A
AAARSFA
L
A
NAD
V
V
ML
VG
A
R
L
NW
L
LAHGKKG
W
A
A
-
D
T
QF
I
Q
L
DI
E
P
Q
EI
DSNRPIA
V
P
V
VGD
IASS
M
QG
M
L
AE
L
KQNTFTT
PL
V
--
--
W
R
D
ILNIH
K
QQNAQKMHEKLST
D
----------------------------
T
-
-QPLNYFNA
L
SA
VRDV
LRENQDIY
L
V
NE
G
AN
T
L
D
N
A
RN
I
IDMYK
PR
RR
L
D
C
G
--------
TW
G
V
MG
I
G
MG
Y
AIGA
SV
T
S
G
S-P
VV
A
IE
GD
S
AFG
F
SGM
E
IE
T
IC
R
YN
LPV
T
IV
IF
NN
G-
-
G
I
Y
R
G
DGVD
L
SGAGAPSPTDLLHH
-----------
AR
Y
DK
L
M
D
A
F
R
GV
G
YN
V
TTTD
E
LRH
AL
TTGIQS
---
RK
P
TI
I
N
V
V
ID
PA
AGTESGHIT
KLN
P
K
Q
VA
G
fig|155864.1.peg.3251
Escherichia coli O157:H7 EDL933 (13-563/564)
IIV
EA
L
KQN
NI
DT
I
Y
G
VV
G
IP
V
TD
M
A
R
H
A
QAE
-
G
-
I
R
Y
I
GF
RHEQ
S
A
GYA
A
A
A
S
G
FLT
Q
K
P
G
I
--
C
LTV
S
A
PG
F
L
N
G
L
T
A
LA
N
A
TV
N
GF
P
M
I
M
ISG
SSDRAI
VDLQ
Q
G
D
YE
E
L
D
QM
--------
NAAKPYA
K
AAF
R
V
NQP
Q
DL
G
IA
L
AR
A
IRV
S
V
S
-
GRPG
G
V
Y
L
DLP
A
N
V
LAATMEKD
---
EALTTIVKVENPS
P
ALLPCPKS
V
TS
A
ISL
L
AK
A
ER
P
L
I
IL
G
K
G
AAY
S
Q
A
DEQ
L
R
E
FIESAQI
P
FLPM
S
M
AK
G
IL
E
DT
HP
---
--
-
-
L
S
A
AAARSFA
L
A
NAD
V
V
ML
VG
A
R
L
NW
L
LAHGKKG
W
A
A
-
D
T
QF
I
Q
L
DI
E
P
Q
EI
DSNRPIA
V
P
V
VGD
IASS
M
QG
M
L
AE
L
KQNTFTT
PL
V
--
--
W
R
D
ILNIH
K
QQNAQKMHEKLST
D
----------------------------
T
-
-QPLNYFNA
L
SA
VRDV
LRENQDIY
L
V
NE
G
AN
T
L
D
N
A
RN
I
IDMYK
PR
RR
L
D
C
G
--------
TW
G
V
MG
I
G
MG
Y
AIGA
SV
T
S
G
S-P
VV
A
IE
GD
S
AFG
F
SGM
E
IE
T
IC
R
YN
LPV
T
IV
IF
NN
G-
-
G
I
Y
R
G
DGVD
L
SGAGAPSPTDLLHH
-----------
AR
Y
DK
L
M
D
A
F
R
GV
G
YN
V
TTTD
E
LRH
AL
TTGIQS
---
RK
P
TI
I
N
V
V
ID
PA
AGTESGHIT
KLN
P
K
Q
VA
G
fig|155864.8.peg.3153
Escherichia coli O157:H7 EDL933 (13-563/564)
IIV
EA
L
KQN
NI
DT
I
Y
G
VV
G
IP
V
TD
M
A
R
H
A
QAE
-
G
-
I
R
Y
I
GF
RHEQ
S
A
GYA
A
A
A
S
G
FLT
Q
K
P
G
I
--
C
LTV
S
A
PG
F
L
N
G
L
T
A
LA
N
A
TV
N
GF
P
M
I
M
ISG
SSDRAI
VDLQ
Q
G
D
YE
E
L
D
QM
--------
NAAKPYA
K
AAF
R
V
NQP
Q
DL
G
IA
L
AR
A
IRV
S
V
S
-
GRPG
G
V
Y
L
DLP
A
N
V
LAATMEKD
---
EALTTIVKVENPS
P
ALLPCPKS
V
TS
A
ISL
L
AK
A
ER
P
L
I
IL
G
K
G
AAY
S
Q
A
DEQ
L
R
E
FIESAQI
P
FLPM
S
M
AK
G
IL
E
DT
HP
---
--
-
-
L
S
A
AAARSFA
L
A
NAD
V
V
ML
VG
A
R
L
NW
L
LAHGKKG
W
A
A
-
D
T
QF
I
Q
L
DI
E
P
Q
EI
DSNRPIA
V
P
V
VGD
IASS
M
QG
M
L
AE
L
KQNTFTT
PL
V
--
--
W
R
D
ILNIH
K
QQNAQKMHEKLST
D
----------------------------
T
-
-QPLNYFNA
L
SA
VRDV
LRENQDIY
L
V
NE
G
AN
T
L
D
N
A
RN
I
IDMYK
PR
RR
L
D
C
G
--------
TW
G
V
MG
I
G
MG
Y
AIGA
SV
T
S
G
S-P
VV
A
IE
GD
S
AFG
F
SGM
E
IE
T
IC
R
YN
LPV
T
IV
IF
NN
G-
-
G
I
Y
R
G
DGVD
L
SGAGAPSPTDLLHH
-----------
AR
Y
DK
L
M
D
A
F
R
GV
G
YN
V
TTTD
E
LRH
AL
TTGIQS
---
RK
P
TI
I
N
V
V
ID
PA
AGTESGHIT
KLN
P
K
Q
VA
G
fig|444454.5.peg.2268
Escherichia coli O157:H7 str. EC4024 (13-563/564)
IIV
EA
L
KQN
NI
DT
I
Y
G
VV
G
IP
V
TD
M
A
R
H
A
QAE
-
G
-
I
R
Y
I
GF
RHEQ
S
A
GYA
A
A
A
S
G
FLT
Q
K
P
G
I
--
C
LTV
S
A
PG
F
L
N
G
L
T
A
LA
N
A
TV
N
GF
P
M
I
M
ISG
SSDRAI
VDLQ
Q
G
D
YE
E
L
D
QM
--------
NAAKPYA
K
AAF
R
V
NQP
Q
DL
G
IA
L
AR
A
IRV
S
V
S
-
GRPG
G
V
Y
L
DLP
A
N
V
LAATMEKD
---
EALTTIVKVENPS
P
ALLPCPKS
V
TS
A
ISL
L
AK
A
ER
P
L
I
IL
G
K
G
AAY
S
Q
A
DEQ
L
R
E
FIESAQI
P
FLPM
S
M
AK
G
IL
E
DT
HP
---
--
-
-
L
S
A
AAARSFA
L
A
NAD
V
V
ML
VG
A
R
L
NW
L
LAHGKKG
W
A
A
-
D
T
QF
I
Q
L
DI
E
P
Q
EI
DSNRPIA
V
P
V
VGD
IASS
M
QG
M
L
AE
L
KQNTFTT
PL
V
--
--
W
R
D
ILNIH
K
QQNAQKMHEKLST
D
----------------------------
T
-
-QPLNYFNA
L
SA
VRDV
LRENQDIY
L
V
NE
G
AN
T
L
D
N
A
RN
I
IDMYK
PR
RR
L
D
C
G
--------
TW
G
V
MG
I
G
MG
Y
AIGA
SV
T
S
G
S-P
VV
A
IE
GD
S
AFG
F
SGM
E
IE
T
IC
R
YN
LPV
T
IV
IF
NN
G-
-
G
I
Y
R
G
DGVD
L
SGAGAPSPTDLLHH
-----------
AR
Y
DK
L
M
D
A
F
R
GV
G
YN
V
TTTD
E
LRH
AL
TTGIQS
---
RK
P
TI
I
N
V
V
ID
PA
AGTESGHIT
KLN
P
K
Q
VA
G
fig|444449.5.peg.1735
Escherichia coli O157:H7 str. EC4042 (13-563/564)
IIV
EA
L
KQN
NI
DT
I
Y
G
VV
G
IP
V
TD
M
A
R
H
A
QAE
-
G
-
I
R
Y
I
GF
RHEQ
S
A
GYA
A
A
A
S
G
FLT
Q
K
P
G
I
--
C
LTV
S
A
PG
F
L
N
G
L
T
A
LA
N
A
TV
N
GF
P
M
I
M
ISG
SSDRAI
VDLQ
Q
G
D
YE
E
L
D
QM
--------
NAAKPYA
K
AAF
R
V
NQP
Q
DL
G
IA
L
AR
A
IRV
S
V
S
-
GRPG
G
V
Y
L
DLP
A
N
V
LAATMEKD
---
EALTTIVKVENPS
P
ALLPCPKS
V
TS
A
ISL
L
AK
A
ER
P
L
I
IL
G
K
G
AAY
S
Q
A
DEQ
L
R
E
FIESAQI
P
FLPM
S
M
AK
G
IL
E
DT
HP
---
--
-
-
L
S
A
AAARSFA
L
A
NAD
V
V
ML
VG
A
R
L
NW
L
LAHGKKG
W
A
A
-
D
T
QF
I
Q
L
DI
E
P
Q
EI
DSNRPIA
V
P
V
VGD
IASS
M
QG
M
L
AE
L
KQNTFTT
PL
V
--
--
W
R
D
ILNIH
K
QQNAQKMHEKLST
D
----------------------------
T
-
-QPLNYFNA
L
SA
VRDV
LRENQDIY
L
V
NE
G
AN
T
L
D
N
A
RN
I
IDMYK
PR
RR
L
D
C
G
--------
TW
G
V
MG
I
G
MG
Y
AIGA
SV
T
S
G
S-P
VV
A
IE
GD
S
AFG
F
SGM
E
IE
T
IC
R
YN
LPV
T
IV
IF
NN
G-
-
G
I
Y
R
G
DGVD
L
SGAGAPSPTDLLHH
-----------
AR
Y
DK
L
M
D
A
F
R
GV
G
YN
V
TTTD
E
LRH
AL
TTGIQS
---
RK
P
TI
I
N
V
V
ID
PA
AGTESGHIT
KLN
P
K
Q
VA
G
fig|444448.5.peg.489
Escherichia coli O157:H7 str. EC4045 (13-563/564)
IIV
EA
L
KQN
NI
DT
I
Y
G
VV
G
IP
V
TD
M
A
R
H
A
QAE
-
G
-
I
R
Y
I
GF
RHEQ
S
A
GYA
A
A
A
S
G
FLT
Q
K
P
G
I
--
C
LTV
S
A
PG
F
L
N
G
L
T
A
LA
N
A
TV
N
GF
P
M
I
M
ISG
SSDRAI
VDLQ
Q
G
D
YE
E
L
D
QM
--------
NAAKPYA
K
AAF
R
V
NQP
Q
DL
G
IA
L
AR
A
IRV
S
V
S
-
GRPG
G
V
Y
L
DLP
A
N
V
LAATMEKD
---
EALTTIVKVENPS
P
ALLPCPKS
V
TS
A
ISL
L
AK
A
ER
P
L
I
IL
G
K
G
AAY
S
Q
A
DEQ
L
R
E
FIESAQI
P
FLPM
S
M
AK
G
IL
E
DT
HP
---
--
-
-
L
S
A
AAARSFA
L
A
NAD
V
V
ML
VG
A
R
L
NW
L
LAHGKKG
W
A
A
-
D
T
QF
I
Q
L
DI
E
P
Q
EI
DSNRPIA
V
P
V
VGD
IASS
M
QG
M
L
AE
L
KQNTFTT
PL
V
--
--
W
R
D
ILNIH
K
QQNAQKMHEKLST
D
----------------------------
T
-
-QPLNYFNA
L
SA
VRDV
LRENQDIY
L
V
NE
G
AN
T
L
D
N
A
RN
I
IDMYK
PR
RR
L
D
C
G
--------
TW
G
V
MG
I
G
MG
Y
AIGA
SV
T
S
G
S-P
VV
A
IE
GD
S
AFG
F
SGM
E
IE
T
IC
R
YN
LPV
T
IV
IF
NN
G-
-
G
I
Y
R
G
DGVD
L
SGAGAPSPTDLLHH
-----------
AR
Y
DK
L
M
D
A
F
R
GV
G
YN
V
TTTD
E
LRH
AL
TTGIQS
---
RK
P
TI
I
N
V
V
ID
PA
AGTESGHIT
KLN
P
K
Q
VA
G
fig|444453.5.peg.1838
Escherichia coli O157:H7 str. EC4076 (13-563/564)
IIV
EA
L
KQN
NI
DT
I
Y
G
VV
G
IP
V
TD
M
A
R
H
A
QAE
-
G
-
I
R
Y
I
GF
RHEQ
S
A
GYA
A
A
A
S
G
FLT
Q
K
P
G
I
--
C
LTV
S
A
PG
F
L
N
G
L
T
A
LA
N
A
TV
N
GF
P
M
I
M
ISG
SSDRAI
VDLQ
Q
G
D
YE
E
L
D
QM
--------
NAAKPYA
K
AAF
R
V
NQP
Q
DL
G
IA
L
AR
A
IRV
S
V
S
-
GRPG
G
V
Y
L
DLP
A
N
V
LAATMEKD
---
EALTTIVKVENPS
P
ALLPCPKS
V
TS
A
ISL
L
AK
A
ER
P
L
I
IL
G
K
G
AAY
S
Q
A
DEQ
L
R
E
FIESAQI
P
FLPM
S
M
AK
G
IL
E
DT
HP
---
--
-
-
L
S
A
AAARSFA
L
A
NAD
V
V
ML
VG
A
R
L
NW
L
LAHGKKG
W
A
A
-
D
T
QF
I
Q
L
DI
E
P
Q
EI
DSNRPIA
V
P
V
VGD
IASS
M
QG
M
L
AE
L
KQNTFTT
PL
V
--
--
W
R
D
ILNIH
K
QQNAQKMHEKLST
D
----------------------------
T
-
-QPLNYFNA
L
SA
VRDV
LRENQDIY
L
V
NE
G
AN
T
L
D
N
A
RN
I
IDMYK
PR
RR
L
D
C
G
--------
TW
G
V
MG
I
G
MG
Y
AIGA
SV
T
S
G
S-P
VV
A
IE
GD
S
AFG
F
SGM
E
IE
T
IC
R
YN
LPV
T
IV
IF
NN
G-
-
G
I
Y
R
G
DGVD
L
SGAGAPSPTDLLHH
-----------
AR
Y
DK
L
M
D
A
F
R
GV
G
YN
V
TTTD
E
LRH
AL
TTGIQS
---
RK
P
TI
I
N
V
V
ID
PA
AGTESGHIT
KLN
P
K
Q
VA
G
fig|444452.5.peg.1402
Escherichia coli O157:H7 str. EC4113 (13-563/564)
IIV
EA
L
KQN
NI
DT
I
Y
G
VV
G
IP
V
TD
M
A
R
H
A
QAE
-
G
-
I
R
Y
I
GF
RHEQ
S
A
GYA
A
A
A
S
G
FLT
Q
K
P
G
I
--
C
LTV
S
A
PG
F
L
N
G
L
T
A
LA
N
A
TV
N
GF
P
M
I
M
ISG
SSDRAI
VDLQ
Q
G
D
YE
E
L
D
QM
--------
NAAKPYA
K
AAF
R
V
NQP
Q
DL
G
IA
L
AR
A
IRV
S
V
S
-
GRPG
G
V
Y
L
DLP
A
N
V
LAATMEKD
---
EALTTIVKVENPS
P
ALLPCPKS
V
TS
A
ISL
L
AK
A
ER
P
L
I
IL
G
K
G
AAY
S
Q
A
DEQ
L
R
E
FIESAQI
P
FLPM
S
M
AK
G
IL
E
DT
HP
---
--
-
-
L
S
A
AAARSFA
L
A
NAD
V
V
ML
VG
A
R
L
NW
L
LAHGKKG
W
A
A
-
D
T
QF
I
Q
L
DI
E
P
Q
EI
DSNRPIA
V
P
V
VGD
IASS
M
QG
M
L
AE
L
KQNTFTT
PL
V
--
--
W
R
D
ILNIH
K
QQNAQKMHEKLST
D
----------------------------
T
-
-QPLNYFNA
L
SA
VRDV
LRENQDIY
L
V
NE
G
AN
T
L
D
N
A
RN
I
IDMYK
PR
RR
L
D
C
G
--------
TW
G
V
MG
I
G
MG
Y
AIGA
SV
T
S
G
S-P
VV
A
IE
GD
S
AFG
F
SGM
E
IE
T
IC
R
YN
LPV
T
IV
IF
NN
G-
-
G
I
Y
R
G
DGVD
L
SGAGAPSPTDLLHH
-----------
AR
Y
DK
L
M
D
A
F
R
GV
G
YN
V
TTTD
E
LRH
AL
TTGIQS
---
RK
P
TI
I
N
V
V
ID
PA
AGTESGHIT
KLN
P
K
Q
VA
G
fig|444450.8.peg.3578
Escherichia coli O157:H7 str. EC4115 (13-563/564)
IIV
EA
L
KQN
NI
DT
I
Y
G
VV
G
IP
V
TD
M
A
R
H
A
QAE
-
G
-
I
R
Y
I
GF
RHEQ
S
A
GYA
A
A
A
S
G
FLT
Q
K
P
G
I
--
C
LTV
S
A
PG
F
L
N
G
L
T
A
LA
N
A
TV
N
GF
P
M
I
M
ISG
SSDRAI
VDLQ
Q
G
D
YE
E
L
D
QM
--------
NAAKPYA
K
AAF
R
V
NQP
Q
DL
G
IA
L
AR
A
IRV
S
V
S
-
GRPG
G
V
Y
L
DLP
A
N
V
LAATMEKD
---
EALTTIVKVENPS
P
ALLPCPKS
V
TS
A
ISL
L
AK
A
ER
P
L
I
IL
G
K
G
AAY
S
Q
A
DEQ
L
R
E
FIESAQI
P
FLPM
S
M
AK
G
IL
E
DT
HP
---
--
-
-
L
S
A
AAARSFA
L
A
NAD
V
V
ML
VG
A
R
L
NW
L
LAHGKKG
W
A
A
-
D
T
QF
I
Q
L
DI
E
P
Q
EI
DSNRPIA
V
P
V
VGD
IASS
M
QG
M
L
AE
L
KQNTFTT
PL
V
--
--
W
R
D
ILNIH
K
QQNAQKMHEKLST
D
----------------------------
T
-
-QPLNYFNA
L
SA
VRDV
LRENQDIY
L
V
NE
G
AN
T
L
D
N
A
RN
I
IDMYK
PR
RR
L
D
C
G
--------
TW
G
V
MG
I
G
MG
Y
AIGA
SV
T
S
G
S-P
VV
A
IE
GD
S
AFG
F
SGM
E
IE
T
IC
R
YN
LPV
T
IV
IF
NN
G-
-
G
I
Y
R
G
DGVD
L
SGAGAPSPTDLLHH
-----------
AR
Y
DK
L
M
D
A
F
R
GV
G
YN
V
TTTD
E
LRH
AL
TTGIQS
---
RK
P
TI
I
N
V
V
ID
PA
AGTESGHIT
KLN
P
K
Q
VA
G
fig|444451.5.peg.543
Escherichia coli O157:H7 str. EC4196 (13-563/564)
IIV
EA
L
KQN
NI
DT
I
Y
G
VV
G
IP
V
TD
M
A
R
H
A
QAE
-
G
-
I
R
Y
I
GF
RHEQ
S
A
GYA
A
A
A
S
G
FLT
Q
K
P
G
I
--
C
LTV
S
A
PG
F
L
N
G
L
T
A
LA
N
A
TV
N
GF
P
M
I
M
ISG
SSDRAI
VDLQ
Q
G
D
YE
E
L
D
QM
--------
NAAKPYA
K
AAF
R
V
NQP
Q
DL
G
IA
L
AR
A
IRV
S
V
S
-
GRPG
G
V
Y
L
DLP
A
N
V
LAATMEKD
---
EALTTIVKVENPS
P
ALLPCPKS
V
TS
A
ISL
L
AK
A
ER
P
L
I
IL
G
K
G
AAY
S
Q
A
DEQ
L
R
E
FIESAQI
P
FLPM
S
M
AK
G
IL
E
DT
HP
---
--
-
-
L
S
A
AAARSFA
L
A
NAD
V
V
ML
VG
A
R
L
NW
L
LAHGKKG
W
A
A
-
D
T
QF
I
Q
L
DI
E
P
Q
EI
DSNRPIA
V
P
V
VGD
IASS
M
QG
M
L
AE
L
KQNTFTT
PL
V
--
--
W
R
D
ILNIH
K
QQNAQKMHEKLST
D
----------------------------
T
-
-QPLNYFNA
L
SA
VRDV
LRENQDIY
L
V
NE
G
AN
T
L
D
N
A
RN
I
IDMYK
PR
RR
L
D
C
G
--------
TW
G
V
MG
I
G
MG
Y
AIGA
SV
T
S
G
S-P
VV
A
IE
GD
S
AFG
F
SGM
E
IE
T
IC
R
YN
LPV
T
IV
IF
NN
G-
-
G
I
Y
R
G
DGVD
L
SGAGAPSPTDLLHH
-----------
AR
Y
DK
L
M
D
A
F
R
GV
G
YN
V
TTTD
E
LRH
AL
TTGIQS
---
RK
P
TI
I
N
V
V
ID
PA
AGTESGHIT
KLN
P
K
Q
VA
G
fig|444447.5.peg.625
Escherichia coli O157:H7 str. EC4206 (13-563/564)
IIV
EA
L
KQN
NI
DT
I
Y
G
VV
G
IP
V
TD
M
A
R
H
A
QAE
-
G
-
I
R
Y
I
GF
RHEQ
S
A
GYA
A
A
A
S
G
FLT
Q
K
P
G
I
--
C
LTV
S
A
PG
F
L
N
G
L
T
A
LA
N
A
TV
N
GF
P
M
I
M
ISG
SSDRAI
VDLQ
Q
G
D
YE
E
L
D
QM
--------
NAAKPYA
K
AAF
R
V
NQP
Q
DL
G
IA
L
AR
A
IRV
S
V
S
-
GRPG
G
V
Y
L
DLP
A
N
V
LAATMEKD
---
EALTTIVKVENPS
P
ALLPCPKS
V
TS
A
ISL
L
AK
A
ER
P
L
I
IL
G
K
G
AAY
S
Q
A
DEQ
L
R
E
FIESAQI
P
FLPM
S
M
AK
G
IL
E
DT
HP
---
--
-
-
L
S
A
AAARSFA
L
A
NAD
V
V
ML
VG
A
R
L
NW
L
LAHGKKG
W
A
A
-
D
T
QF
I
Q
L
DI
E
P
Q
EI
DSNRPIA
V
P
V
VGD
IASS
M
QG
M
L
AE
L
KQNTFTT
PL
V
--
--
W
R
D
ILNIH
K
QQNAQKMHEKLST
D
----------------------------
T
-
-QPLNYFNA
L
SA
VRDV
LRENQDIY
L
V
NE
G
AN
T
L
D
N
A
RN
I
IDMYK
PR
RR
L
D
C
G
--------
TW
G
V
MG
I
G
MG
Y
AIGA
SV
T
S
G
S-P
VV
A
IE
GD
S
AFG
F
SGM
E
IE
T
IC
R
YN
LPV
T
IV
IF
NN
G-
-
G
I
Y
R
G
DGVD
L
SGAGAPSPTDLLHH
-----------
AR
Y
DK
L
M
D
A
F
R
GV
G
YN
V
TTTD
E
LRH
AL
TTGIQS
---
RK
P
TI
I
N
V
V
ID
PA
AGTESGHIT
KLN
P
K
Q
VA
G
fig|478004.5.peg.4073
Escherichia coli O157:H7 str. EC4401 (13-563/564)
IIV
EA
L
KQN
NI
DT
I
Y
G
VV
G
IP
V
TD
M
A
R
H
A
QAE
-
G
-
I
R
Y
I
GF
RHEQ
S
A
GYA
A
A
A
S
G
FLT
Q
K
P
G
I
--
C
LTV
S
A
PG
F
L
N
G
L
T
A
LA
N
A
TV
N
GF
P
M
I
M
ISG
SSDRAI
VDLQ
Q
G
D
YE
E
L
D
QM
--------
NAAKPYA
K
AAF
R
V
NQP
Q
DL
G
IA
L
AR
A
IRV
S
V
S
-
GRPG
G
V
Y
L
DLP
A
N
V
LAATMEKD
---
EALTTIVKVENPS
P
ALLPCPKS
V
TS
A
ISL
L
AK
A
ER
P
L
I
IL
G
K
G
AAY
S
Q
A
DEQ
L
R
E
FIESAQI
P
FLPM
S
M
AK
G
IL
E
DT
HP
---
--
-
-
L
S
A
AAARSFA
L
A
NAD
V
V
ML
VG
A
R
L
NW
L
LAHGKKG
W
A
A
-
D
T
QF
I
Q
L
DI
E
P
Q
EI
DSNRPIA
V
P
V
VGD
IASS
M
QG
M
L
AE
L
KQNTFTT
PL
V
--
--
W
R
D
ILNIH
K
QQNAQKMHEKLST
D
----------------------------
T
-
-QPLNYFNA
L
SA
VRDV
LRENQDIY
L
V
NE
G
AN
T
L
D
N
A
RN
I
IDMYK
PR
RR
L
D
C
G
--------
TW
G
V
MG
I
G
MG
Y
AIGA
SV
T
S
G
S-P
VV
A
IE
GD
S
AFG
F
SGM
E
IE
T
IC
R
YN
LPV
T
IV
IF
NN
G-
-
G
I
Y
R
G
DGVD
L
SGAGAPSPTDLLHH
-----------
AR
Y
DK
L
M
D
A
F
R
GV
G
YN
V
TTTD
E
LRH
AL
TTGIQS
---
RK
P
TI
I
N
V
V
ID
PA
AGTESGHIT
KLN
P
K
Q
VA
G
fig|478005.5.peg.4630
Escherichia coli O157:H7 str. EC4486 (13-563/564)
IIV
EA
L
KQN
NI
DT
I
Y
G
VV
G
IP
V
TD
M
A
R
H
A
QAE
-
G
-
I
R
Y
I
GF
RHEQ
S
A
GYA
A
A
A
S
G
FLT
Q
K
P
G
I
--
C
LTV
S
A
PG
F
L
N
G
L
T
A
LA
N
A
TV
N
GF
P
M
I
M
ISG
SSDRAI
VDLQ
Q
G
D
YE
E
L
D
QM
--------
NAAKPYA
K
AAF
R
V
NQP
Q
DL
G
IA
L
AR
A
IRV
S
V
S
-
GRPG
G
V
Y
L
DLP
A
N
V
LAATMEKD
---
EALTTIVKVENPS
P
ALLPCPKS
V
TS
A
ISL
L
AK
A
ER
P
L
I
IL
G
K
G
AAY
S
Q
A
DEQ
L
R
E
FIESAQI
P
FLPM
S
M
AK
G
IL
E
DT
HP
---
--
-
-
L
S
A
AAARSFA
L
A
NAD
V
V
ML
VG
A
R
L
NW
L
LAHGKKG
W
A
A
-
D
T
QF
I
Q
L
DI
E
P
Q
EI
DSNRPIA
V
P
V
VGD
IASS
M
QG
M
L
AE
L
KQNTFTT
PL
V
--
--
W
R
D
ILNIH
K
QQNAQKMHEKLST
D
----------------------------
T
-
-QPLNYFNA
L
SA
VRDV
LRENQDIY
L
V
NE
G
AN
T
L
D
N
A
RN
I
IDMYK
PR
RR
L
D
C
G
--------
TW
G
V
MG
I
G
MG
Y
AIGA
SV
T
S
G
S-P
VV
A
IE
GD
S
AFG
F
SGM
E
IE
T
IC
R
YN
LPV
T
IV
IF
NN
G-
-
G
I
Y
R
G
DGVD
L
SGAGAPSPTDLLHH
-----------
AR
Y
DK
L
M
D
A
F
R
GV
G
YN
V
TTTD
E
LRH
AL
TTGIQS
---
RK
P
TI
I
N
V
V
ID
PA
AGTESGHIT
KLN
P
K
Q
VA
G
fig|478006.5.peg.3938
Escherichia coli O157:H7 str. EC4501 (13-563/564)
IIV
EA
L
KQN
NI
DT
I
Y
G
VV
G
IP
V
TD
M
A
R
H
A
QAE
-
G
-
I
R
Y
I
GF
RHEQ
S
A
GYA
A
A
A
S
G
FLT
Q
K
P
G
I
--
C
LTV
S
A
PG
F
L
N
G
L
T
A
LA
N
A
TV
N
GF
P
M
I
M
ISG
SSDRAI
VDLQ
Q
G
D
YE
E
L
D
QM
--------
NAAKPYA
K
AAF
R
V
NQP
Q
DL
G
IA
L
AR
A
IRV
S
V
S
-
GRPG
G
V
Y
L
DLP
A
N
V
LAATMEKD
---
EALTTIVKVENPS
P
ALLPCPKS
V
TS
A
ISL
L
AK
A
ER
P
L
I
IL
G
K
G
AAY
S
Q
A
DEQ
L
R
E
FIESAQI
P
FLPM
S
M
AK
G
IL
E
DT
HP
---
--
-
-
L
S
A
AAARSFA
L
A
NAD
V
V
ML
VG
A
R
L
NW
L
LAHGKKG
W
A
A
-
D
T
QF
I
Q
L
DI
E
P
Q
EI
DSNRPIA
V
P
V
VGD
IASS
M
QG
M
L
AE
L
KQNTFTT
PL
V
--
--
W
R
D
ILNIH
K
QQNAQKMHEKLST
D
----------------------------
T
-
-QPLNYFNA
L
SA
VRDV
LRENQDIY
L
V
NE
G
AN
T
L
D
N
A
RN
I
IDMYK
PR
RR
L
D
C
G
--------
TW
G
V
MG
I
G
MG
Y
AIGA
SV
T
S
G
S-P
VV
A
IE
GD
S
AFG
F
SGM
E
IE
T
IC
R
YN
LPV
T
IV
IF
NN
G-
-
G
I
Y
R
G
DGVD
L
SGAGAPSPTDLLHH
-----------
AR
Y
DK
L
M
D
A
F
R
GV
G
YN
V
TTTD
E
LRH
AL
TTGIQS
---
RK
P
TI
I
N
V
V
ID
PA
AGTESGHIT
KLN
P
K
Q
VA
G
fig|478007.5.peg.3383
Escherichia coli O157:H7 str. EC508 (13-563/564)
IIV
EA
L
KQN
NI
DT
I
Y
G
VV
G
IP
V
TD
M
A
R
H
A
QAE
-
G
-
I
R
Y
I
GF
RHEQ
S
A
GYA
A
A
A
S
G
FLT
Q
K
P
G
I
--
C
LTV
S
A
PG
F
L
N
G
L
T
A
LA
N
A
TV
N
GF
P
M
I
M
ISG
SSDRAI
VDLQ
Q
G
D
YE
E
L
D
QM
--------
NAAKPYA
K
AAF
R
V
NQP
Q
DL
G
IA
L
AR
A
IRV
S
V
S
-
GRPG
G
V
Y
L
DLP
A
N
V
LAATMEKD
---
EALTTIVKVENPS
P
ALLPCPKS
V
TS
A
ISL
L
AK
A
ER
P
L
I
IL
G
K
G
AAY
S
Q
A
DEQ
L
R
E
FIESAQI
P
FLPM
S
M
AK
G
IL
E
DT
HP
---
--
-
-
L
S
A
AAARSFA
L
A
NAD
V
V
ML
VG
A
R
L
NW
L
LAHGKKG
W
A
A
-
D
T
QF
I
Q
L
DI
E
P
Q
EI
DSNRPIA
V
P
V
VGD
IASS
M
QG
M
L
AE
L
KQNTFTT
PL
V
--
--
W
R
D
ILNIH
K
QQNAQKMHEKLST
D
----------------------------
T
-
-QPLNYFNA
L
SA
VRDV
LRENQDIY
L
V
NE
G
AN
T
L
D
N
A
RN
I
IDMYK
PR
RR
L
D
C
G
--------
TW
G
V
MG
I
G
MG
Y
AIGA
SV
T
S
G
S-P
VV
A
IE
GD
S
AFG
F
SGM
E
IE
T
IC
R
YN
LPV
T
IV
IF
NN
G-
-
G
I
Y
R
G
DGVD
L
SGAGAPSPTDLLHH
-----------
AR
Y
DK
L
M
D
A
F
R
GV
G
YN
V
TTTD
E
LRH
AL
TTGIQS
---
RK
P
TI
I
N
V
V
ID
PA
AGTESGHIT
KLN
P
K
Q
VA
G
fig|478008.5.peg.2531
Escherichia coli O157:H7 str. EC869 (13-563/564)
IIV
EA
L
KQN
NI
DT
I
Y
G
VV
G
IP
V
TD
M
A
R
H
A
QAE
-
G
-
I
R
Y
I
GF
RHEQ
S
A
GYA
A
A
A
S
G
FLT
Q
K
P
G
I
--
C
LTV
S
A
PG
F
L
N
G
L
T
A
LA
N
A
TV
N
GF
P
M
I
M
ISG
SSDRAI
VDLQ
Q
G
D
YE
E
L
D
QM
--------
NAAKPYA
K
AAF
R
V
NQP
Q
DL
G
IA
L
AR
A
IRV
S
V
S
-
GRPG
G
V
Y
L
DLP
A
N
V
LAATMEKD
---
EALTTIVKVENPS
P
ALLPCPKS
V
TS
A
ISL
L
AK
A
ER
P
L
I
IL
G
K
G
AAY
S
Q
A
DEQ
L
R
E
FIESAQI
P
FLPM
S
M
AK
G
IL
E
DT
HP
---
--
-
-
L
S
A
AAARSFA
L
A
NAD
V
V
ML
VG
A
R
L
NW
L
LAHGKKG
W
A
A
-
D
T
QF
I
Q
L
DI
E
P
Q
EI
DSNRPIA
V
P
V
VGD
IASS
M
QG
M
L
AE
L
KQNTFTT
PL
V
--
--
W
R
D
ILNIH
K
QQNAQKMHEKLST
D
----------------------------
T
-
-QPLNYFNA
L
SA
VRDV
LRENQDIY
L
V
NE
G
AN
T
L
D
N
A
RN
I
IDMYK
PR
RR
L
D
C
G
--------
TW
G
V
MG
I
G
MG
Y
AIGA
SV
T
S
G
S-P
VV
A
IE
GD
S
AFG
F
SGM
E
IE
T
IC
R
YN
LPV
T
IV
IF
NN
G-
-
G
I
Y
R
G
DGVD
L
SGAGAPSPTDLLHH
-----------
AR
Y
DK
L
M
D
A
F
R
GV
G
YN
V
TTTD
E
LRH
AL
TTGIQS
---
RK
P
TI
I
N
V
V
ID
PA
AGTESGHIT
KLN
P
K
Q
VA
G
fig|637388.3.peg.212
Escherichia coli O157:H7 str. FRIK2000 (13-563/564)
IIV
EA
L
KQN
NI
DT
I
Y
G
VV
G
IP
V
TD
M
A
R
H
A
QAE
-
G
-
I
R
Y
I
GF
RHEQ
S
A
GYA
A
A
A
S
G
FLT
Q
K
P
G
I
--
C
LTV
S
A
PG
F
L
N
G
L
T
A
LA
N
A
TV
N
GF
P
M
I
M
ISG
SSDRAI
VDLQ
Q
G
D
YE
E
L
D
QM
--------
NAAKPYA
K
AAF
R
V
NQP
Q
DL
G
IA
L
AR
A
IRV
S
V
S
-
GRPG
G
V
Y
L
DLP
A
N
V
LAATMEKD
---
EALTTIVKVENPS
P
ALLPCPKS
V
TS
A
ISL
L
AK
A
ER
P
L
I
IL
G
K
G
AAY
S
Q
A
DEQ
L
R
E
FIESAQI
P
FLPM
S
M
AK
G
IL
E
DT
HP
---
--
-
-
L
S
A
AAARSFA
L
A
NAD
V
V
ML
VG
A
R
L
NW
L
LAHGKKG
W
A
A
-
D
T
QF
I
Q
L
DI
E
P
Q
EI
DSNRPIA
V
P
V
VGD
IASS
M
QG
M
L
AE
L
KQNTFTT
PL
V
--
--
W
R
D
ILNIH
K
QQNAQKMHEKLST
D
----------------------------
T
-
-QPLNYFNA
L
SA
VRDV
LRENQDIY
L
V
NE
G
AN
T
L
D
N
A
RN
I
IDMYK
PR
RR
L
D
C
G
--------
TW
G
V
MG
I
G
MG
Y
AIGA
SV
T
S
G
S-P
VV
A
IE
GD
S
AFG
F
SGM
E
IE
T
IC
R
YN
LPV
T
IV
IF
NN
G-
-
G
I
Y
R
G
DGVD
L
SGAGAPSPTDLLHH
-----------
AR
Y
DK
L
M
D
A
F
R
GV
G
YN
V
TTTD
E
LRH
AL
TTGIQS
---
RK
P
TI
I
N
V
V
ID
PA
AGTESGHIT
KLN
P
K
Q
VA
G
fig|386585.9.peg.3397
Escherichia coli O157:H7 str. Sakai (13-563/564)
IIV
EA
L
KQN
NI
DT
I
Y
G
VV
G
IP
V
TD
M
A
R
H
A
QAE
-
G
-
I
R
Y
I
GF
RHEQ
S
A
GYA
A
A
A
S
G
FLT
Q
K
P
G
I
--
C
LTV
S
A
PG
F
L
N
G
L
T
A
LA
N
A
TV
N
GF
P
M
I
M
ISG
SSDRAI
VDLQ
Q
G
D
YE
E
L
D
QM
--------
NAAKPYA
K
AAF
R
V
NQP
Q
DL
G
IA
L
AR
A
IRV
S
V
S
-
GRPG
G
V
Y
L
DLP
A
N
V
LAATMEKD
---
EALTTIVKVENPS
P
ALLPCPKS
V
TS
A
ISL
L
AK
A
ER
P
L
I
IL
G
K
G
AAY
S
Q
A
DEQ
L
R
E
FIESAQI
P
FLPM
S
M
AK
G
IL
E
DT
HP
---
--
-
-
L
S
A
AAARSFA
L
A
NAD
V
V
ML
VG
A
R
L
NW
L
LAHGKKG
W
A
A
-
D
T
QF
I
Q
L
DI
E
P
Q
EI
DSNRPIA
V
P
V
VGD
IASS
M
QG
M
L
AE
L
KQNTFTT
PL
V
--
--
W
R
D
ILNIH
K
QQNAQKMHEKLST
D
----------------------------
T
-
-QPLNYFNA
L
SA
VRDV
LRENQDIY
L
V
NE
G
AN
T
L
D
N
A
RN
I
IDMYK
PR
RR
L
D
C
G
--------
TW
G
V
MG
I
G
MG
Y
AIGA
SV
T
S
G
S-P
VV
A
IE
GD
S
AFG
F
SGM
E
IE
T
IC
R
YN
LPV
T
IV
IF
NN
G-
-
G
I
Y
R
G
DGVD
L
SGAGAPSPTDLLHH
-----------
AR
Y
DK
L
M
D
A
F
R
GV
G
YN
V
TTTD
E
LRH
AL
TTGIQS
---
RK
P
TI
I
N
V
V
ID
PA
AGTESGHIT
KLN
P
K
Q
VA
G
fig|544404.4.peg.3381
Escherichia coli O157:H7 str. TW14359 (13-563/564)
IIV
EA
L
KQN
NI
DT
I
Y
G
VV
G
IP
V
TD
M
A
R
H
A
QAE
-
G
-
I
R
Y
I
GF
RHEQ
S
A
GYA
A
A
A
S
G
FLT
Q
K
P
G
I
--
C
LTV
S
A
PG
F
L
N
G
L
T
A
LA
N
A
TV
N
GF
P
M
I
M
ISG
SSDRAI
VDLQ
Q
G
D
YE
E
L
D
QM
--------
NAAKPYA
K
AAF
R
V
NQP
Q
DL
G
IA
L
AR
A
IRV
S
V
S
-
GRPG
G
V
Y
L
DLP
A
N
V
LAATMEKD
---
EALTTIVKVENPS
P
ALLPCPKS
V
TS
A
ISL
L
AK
A
ER
P
L
I
IL
G
K
G
AAY
S
Q
A
DEQ
L
R
E
FIESAQI
P
FLPM
S
M
AK
G
IL
E
DT
HP
---
--
-
-
L
S
A
AAARSFA
L
A
NAD
V
V
ML
VG
A
R
L
NW
L
LAHGKKG
W
A
A
-
D
T
QF
I
Q
L
DI
E
P
Q
EI
DSNRPIA
V
P
V
VGD
IASS
M
QG
M
L
AE
L
KQNTFTT
PL
V
--
--
W
R
D
ILNIH
K
QQNAQKMHEKLST
D
----------------------------
T
-
-QPLNYFNA
L
SA
VRDV
LRENQDIY
L
V
NE
G
AN
T
L
D
N
A
RN
I
IDMYK
PR
RR
L
D
C
G
--------
TW
G
V
MG
I
G
MG
Y
AIGA
SV
T
S
G
S-P
VV
A
IE
GD
S
AFG
F
SGM
E
IE
T
IC
R
YN
LPV
T
IV
IF
NN
G-
-
G
I
Y
R
G
DGVD
L
SGAGAPSPTDLLHH
-----------
AR
Y
DK
L
M
D
A
F
R
GV
G
YN
V
TTTD
E
LRH
AL
TTGIQS
---
RK
P
TI
I
N
V
V
ID
PA
AGTESGHIT
KLN
P
K
Q
VA
G
fig|502346.5.peg.4037
Escherichia coli O157:H7 str. TW14588 (13-563/564)
IIV
EA
L
KQN
NI
DT
I
Y
G
VV
G
IP
V
TD
M
A
R
H
A
QAE
-
G
-
I
R
Y
I
GF
RHEQ
S
A
GYA
A
A
A
S
G
FLT
Q
K
P
G
I
--
C
LTV
S
A
PG
F
L
N
G
L
T
A
LA
N
A
TV
N
GF
P
M
I
M
ISG
SSDRAI
VDLQ
Q
G
D
YE
E
L
D
QM
--------
NAAKPYA
K
AAF
R
V
NQP
Q
DL
G
IA
L
AR
A
IRV
S
V
S
-
GRPG
G
V
Y
L
DLP
A
N
V
LAATMEKD
---
EALTTIVKVENPS
P
ALLPCPKS
V
TS
A
ISL
L
AK
A
ER
P
L
I
IL
G
K
G
AAY
S
Q
A
DEQ
L
R
E
FIESAQI
P
FLPM
S
M
AK
G
IL
E
DT
HP
---
--
-
-
L
S
A
AAARSFA
L
A
NAD
V
V
ML
VG
A
R
L
NW
L
LAHGKKG
W
A
A
-
D
T
QF
I
Q
L
DI
E
P
Q
EI
DSNRPIA
V
P
V
VGD
IASS
M
QG
M
L
AE
L
KQNTFTT
PL
V
--
--
W
R
D
ILNIH
K
QQNAQKMHEKLST
D
----------------------------
T
-
-QPLNYFNA
L
SA
VRDV
LRENQDIY
L
V
NE
G
AN
T
L
D
N
A
RN
I
IDMYK
PR
RR
L
D
C
G
--------
TW
G
V
MG
I
G
MG
Y
AIGA
SV
T
S
G
S-P
VV
A
IE
GD
S
AFG
F
SGM
E
IE
T
IC
R
YN
LPV
T
IV
IF
NN
G-
-
G
I
Y
R
G
DGVD
L
SGAGAPSPTDLLHH
-----------
AR
Y
DK
L
M
D
A
F
R
GV
G
YN
V
TTTD
E
LRH
AL
TTGIQS
---
RK
P
TI
I
N
V
V
ID
PA
AGTESGHIT
KLN
P
K
Q
VA
G
fig|701177.3.peg.2942
Escherichia coli O55:H7 str. CB9615 (13-563/564)
IIV
EA
L
KQN
NI
DT
I
Y
G
VV
G
IP
V
TD
M
A
R
H
A
QAE
-
G
-
I
R
Y
I
GF
RHEQ
S
A
GYA
A
A
A
S
G
FLT
Q
K
P
G
I
--
C
LTV
S
A
PG
F
L
N
G
L
T
A
LA
N
A
TV
N
GF
P
M
I
M
ISG
SSDRAI
VDLQ
Q
G
D
YE
E
L
D
QM
--------
NAAKPYA
K
AAF
R
V
NQP
Q
DL
G
IA
L
AR
A
IRV
S
V
S
-
GRPG
G
V
Y
L
DLP
A
N
V
LAATMEKD
---
EALTTIVKVENPS
P
ALLPCPKS
V
TS
A
ISL
L
AK
A
ER
P
L
I
IL
G
K
G
AAY
S
Q
A
DEQ
L
R
E
FIESAQI
P
FLPM
S
M
AK
G
IL
E
DT
HP
---
--
-
-
L
S
A
AAARSFA
L
A
NAD
V
V
ML
VG
A
R
L
NW
L
LAHGKKG
W
A
A
-
D
T
QF
I
Q
L
DI
E
P
Q
EI
DSNRPIA
V
P
V
VGD
IASS
M
QG
M
L
AE
L
KQNTFTT
PL
V
--
--
W
R
D
ILNIH
K
QQNAQKMHEKLST
D
----------------------------
T
-
-QPLNYFNA
L
SA
VRDV
LRENQDIY
L
V
NE
G
AN
T
L
D
N
A
RN
I
IDMYK
PR
RR
L
D
C
G
--------
TW
G
V
MG
I
G
MG
Y
AIGA
SV
T
S
G
S-P
VV
A
IE
GD
S
AFG
F
SGM
E
IE
T
IC
R
YN
LPV
T
IV
IF
NN
G-
-
G
I
Y
R
G
DGVD
L
SGAGAPSPTDLLHH
-----------
AR
Y
DK
L
M
D
A
F
R
GV
G
YN
V
TTTD
E
LRH
AL
TTGIQS
---
RK
P
TI
I
N
V
V
ID
PA
AGTESGHIT
KLN
P
K
Q
VA
G
fig|566546.3.peg.1222
Escherichia coli W (13-563/564)
IIV
EA
L
KQN
NI
DT
I
Y
G
VV
G
IP
V
TD
M
A
R
H
A
QAE
-
G
-
I
R
Y
I
GF
RHEQ
S
A
GYA
A
A
A
S
G
FLT
Q
K
P
G
I
--
C
LTV
S
A
PG
F
L
N
G
L
T
A
LA
N
A
TV
N
GF
P
M
I
M
ISG
SSDRAI
VDLQ
Q
G
D
YE
E
L
D
QM
--------
NAAKPYA
K
AAF
R
V
NQP
Q
DL
G
IA
L
AR
A
IRV
S
V
S
-
GRPG
G
V
Y
L
DLP
A
N
V
LAATMEKD
---
EALTTIVKVENPS
P
ALLPCPKS
V
TS
A
ISL
L
AK
A
ER
P
L
I
IL
G
K
G
AAY
S
Q
A
DEQ
L
R
E
FIESAQI
P
FLPM
S
M
AK
G
IL
E
DT
HP
---
--
-
-
L
S
A
AAARSFA
L
A
NAD
V
V
ML
VG
A
R
L
NW
L
LAHGKKG
W
A
A
-
D
T
QF
I
Q
L
DI
E
P
Q
EI
DSNRPIA
V
P
V
VGD
IASS
M
QG
M
L
AE
L
KQNTFTT
PL
V
--
--
W
R
D
ILNIH
K
QQNAQKMHEKLST
D
----------------------------
T
-
-QPLNYFNA
L
SA
VRDV
LRENQDIY
L
V
NE
G
AN
T
L
D
N
A
RN
I
IDMYK
PR
RR
L
D
C
G
--------
TW
G
V
MG
I
G
MG
Y
AIGA
SV
T
S
G
S-P
VV
A
IE
GD
S
AFG
F
SGM
E
IE
T
IC
R
YN
LPV
T
IV
IF
NN
G-
-
G
I
Y
R
G
DGVD
L
SGAGAPSPTDLLHH
-----------
AR
Y
DK
L
M
D
A
F
R
GV
G
YN
V
TTTD
E
LRH
AL
TTGIQS
---
RK
P
TI
I
N
V
V
ID
PA
AGTESGHIT
KLN
P
K
Q
VA
G
fig|566546.4.peg.2583
Escherichia coli W (13-563/564)
IIV
EA
L
KQN
NI
DT
I
Y
G
VV
G
IP
V
TD
M
A
R
H
A
QAE
-
G
-
I
R
Y
I
GF
RHEQ
S
A
GYA
A
A
A
S
G
FLT
Q
K
P
G
I
--
C
LTV
S
A
PG
F
L
N
G
L
T
A
LA
N
A
TV
N
GF
P
M
I
M
ISG
SSDRAI
VDLQ
Q
G
D
YE
E
L
D
QM
--------
NAAKPYA
K
AAF
R
V
NQP
Q
DL
G
IA
L
AR
A
IRV
S
V
S
-
GRPG
G
V
Y
L
DLP
A
N
V
LAATMEKD
---
EALTTIVKVENPS
P
ALLPCPKS
V
TS
A
ISL
L
AK
A
ER
P
L
I
IL
G
K
G
AAY
S
Q
A
DEQ
L
R
E
FIESAQI
P
FLPM
S
M
AK
G
IL
E
DT
HP
---
--
-
-
L
S
A
AAARSFA
L
A
NAD
V
V
ML
VG
A
R
L
NW
L
LAHGKKG
W
A
A
-
D
T
QF
I
Q
L
DI
E
P
Q
EI
DSNRPIA
V
P
V
VGD
IASS
M
QG
M
L
AE
L
KQNTFTT
PL
V
--
--
W
R
D
ILNIH
K
QQNAQKMHEKLST
D
----------------------------
T
-
-QPLNYFNA
L
SA
VRDV
LRENQDIY
L
V
NE
G
AN
T
L
D
N
A
RN
I
IDMYK
PR
RR
L
D
C
G
--------
TW
G
V
MG
I
G
MG
Y
AIGA
SV
T
S
G
S-P
VV
A
IE
GD
S
AFG
F
SGM
E
IE
T
IC
R
YN
LPV
T
IV
IF
NN
G-
-
G
I
Y
R
G
DGVD
L
SGAGAPSPTDLLHH
-----------
AR
Y
DK
L
M
D
A
F
R
GV
G
YN
V
TTTD
E
LRH
AL
TTGIQS
---
RK
P
TI
I
N
V
V
ID
PA
AGTESGHIT
KLN
P
K
Q
VA
G
fig|316407.3.peg.2309
Escherichia coli W3110 (13-563/564)
IIV
EA
L
KQN
NI
DT
I
Y
G
VV
G
IP
V
TD
M
A
R
H
A
QAE
-
G
-
I
R
Y
I
GF
RHEQ
S
A
GYA
A
A
A
S
G
FLT
Q
K
P
G
I
--
C
LTV
S
A
PG
F
L
N
G
L
T
A
LA
N
A
TV
N
GF
P
M
I
M
ISG
SSDRAI
VDLQ
Q
G
D
YE
E
L
D
QM
--------
NAAKPYA
K
AAF
R
V
NQP
Q
DL
G
IA
L
AR
A
IRV
S
V
S
-
GRPG
G
V
Y
L
DLP
A
N
V
LAATMEKD
---
EALTTIVKVENPS
P
ALLPCPKS
V
TS
A
ISL
L
AK
A
ER
P
L
I
IL
G
K
G
AAY
S
Q
A
DEQ
L
R
E
FIESAQI
P
FLPM
S
M
AK
G
IL
E
DT
HP
---
--
-
-
L
S
A
AAARSFA
L
A
NAD
V
V
ML
VG
A
R
L
NW
L
LAHGKKG
W
A
A
-
D
T
QF
I
Q
L
DI
E
P
Q
EI
DSNRPIA
V
P
V
VGD
IASS
M
QG
M
L
AE
L
KQNTFTT
PL
V
--
--
W
R
D
ILNIH
K
QQNAQKMHEKLST
D
----------------------------
T
-
-QPLNYFNA
L
SA
VRDV
LRENQDIY
L
V
NE
G
AN
T
L
D
N
A
RN
I
IDMYK
PR
RR
L
D
C
G
--------
TW
G
V
MG
I
G
MG
Y
AIGA
SV
T
S
G
S-P
VV
A
IE
GD
S
AFG
F
SGM
E
IE
T
IC
R
YN
LPV
T
IV
IF
NN
G-
-
G
I
Y
R
G
DGVD
L
SGAGAPSPTDLLHH
-----------
AR
Y
DK
L
M
D
A
F
R
GV
G
YN
V
TTTD
E
LRH
AL
TTGIQS
---
RK
P
TI
I
N
V
V
ID
PA
AGTESGHIT
KLN
P
K
Q
VA
G
fig|316385.5.peg.2504
Escherichia coli str. K-12 substr. DH10B (13-563/564)
IIV
EA
L
KQN
NI
DT
I
Y
G
VV
G
IP
V
TD
M
A
R
H
A
QAE
-
G
-
I
R
Y
I
GF
RHEQ
S
A
GYA
A
A
A
S
G
FLT
Q
K
P
G
I
--
C
LTV
S
A
PG
F
L
N
G
L
T
A
LA
N
A
TV
N
GF
P
M
I
M
ISG
SSDRAI
VDLQ
Q
G
D
YE
E
L
D
QM
--------
NAAKPYA
K
AAF
R
V
NQP
Q
DL
G
IA
L
AR
A
IRV
S
V
S
-
GRPG
G
V
Y
L
DLP
A
N
V
LAATMEKD
---
EALTTIVKVENPS
P
ALLPCPKS
V
TS
A
ISL
L
AK
A
ER
P
L
I
IL
G
K
G
AAY
S
Q
A
DEQ
L
R
E
FIESAQI
P
FLPM
S
M
AK
G
IL
E
DT
HP
---
--
-
-
L
S
A
AAARSFA
L
A
NAD
V
V
ML
VG
A
R
L
NW
L
LAHGKKG
W
A
A
-
D
T
QF
I
Q
L
DI
E
P
Q
EI
DSNRPIA
V
P
V
VGD
IASS
M
QG
M
L
AE
L
KQNTFTT
PL
V
--
--
W
R
D
ILNIH
K
QQNAQKMHEKLST
D
----------------------------
T
-
-QPLNYFNA
L
SA
VRDV
LRENQDIY
L
V
NE
G
AN
T
L
D
N
A
RN
I
IDMYK
PR
RR
L
D
C
G
--------
TW
G
V
MG
I
G
MG
Y
AIGA
SV
T
S
G
S-P
VV
A
IE
GD
S
AFG
F
SGM
E
IE
T
IC
R
YN
LPV
T
IV
IF
NN
G-
-
G
I
Y
R
G
DGVD
L
SGAGAPSPTDLLHH
-----------
AR
Y
DK
L
M
D
A
F
R
GV
G
YN
V
TTTD
E
LRH
AL
TTGIQS
---
RK
P
TI
I
N
V
V
ID
PA
AGTESGHIT
KLN
P
K
Q
VA
G
fig|511145.12.peg.2471
Escherichia coli str. K-12 substr. MG1655 (13-563/564)
IIV
EA
L
KQN
NI
DT
I
Y
G
VV
G
IP
V
TD
M
A
R
H
A
QAE
-
G
-
I
R
Y
I
GF
RHEQ
S
A
GYA
A
A
A
S
G
FLT
Q
K
P
G
I
--
C
LTV
S
A
PG
F
L
N
G
L
T
A
LA
N
A
TV
N
GF
P
M
I
M
ISG
SSDRAI
VDLQ
Q
G
D
YE
E
L
D
QM
--------
NAAKPYA
K
AAF
R
V
NQP
Q
DL
G
IA
L
AR
A
IRV
S
V
S
-
GRPG
G
V
Y
L
DLP
A
N
V
LAATMEKD
---
EALTTIVKVENPS
P
ALLPCPKS
V
TS
A
ISL
L
AK
A
ER
P
L
I
IL
G
K
G
AAY
S
Q
A
DEQ
L
R
E
FIESAQI
P
FLPM
S
M
AK
G
IL
E
DT
HP
---
--
-
-
L
S
A
AAARSFA
L
A
NAD
V
V
ML
VG
A
R
L
NW
L
LAHGKKG
W
A
A
-
D
T
QF
I
Q
L
DI
E
P
Q
EI
DSNRPIA
V
P
V
VGD
IASS
M
QG
M
L
AE
L
KQNTFTT
PL
V
--
--
W
R
D
ILNIH
K
QQNAQKMHEKLST
D
----------------------------
T
-
-QPLNYFNA
L
SA
VRDV
LRENQDIY
L
V
NE
G
AN
T
L
D
N
A
RN
I
IDMYK
PR
RR
L
D
C
G
--------
TW
G
V
MG
I
G
MG
Y
AIGA
SV
T
S
G
S-P
VV
A
IE
GD
S
AFG
F
SGM
E
IE
T
IC
R
YN
LPV
T
IV
IF
NN
G-
-
G
I
Y
R
G
DGVD
L
SGAGAPSPTDLLHH
-----------
AR
Y
DK
L
M
D
A
F
R
GV
G
YN
V
TTTD
E
LRH
AL
TTGIQS
---
RK
P
TI
I
N
V
V
ID
PA
AGTESGHIT
KLN
P
K
Q
VA
G
fig|511145.6.peg.2455
Escherichia coli str. K-12 substr. MG1655 (13-563/564)
IIV
EA
L
KQN
NI
DT
I
Y
G
VV
G
IP
V
TD
M
A
R
H
A
QAE
-
G
-
I
R
Y
I
GF
RHEQ
S
A
GYA
A
A
A
S
G
FLT
Q
K
P
G
I
--
C
LTV
S
A
PG
F
L
N
G
L
T
A
LA
N
A
TV
N
GF
P
M
I
M
ISG
SSDRAI
VDLQ
Q
G
D
YE
E
L
D
QM
--------
NAAKPYA
K
AAF
R
V
NQP
Q
DL
G
IA
L
AR
A
IRV
S
V
S
-
GRPG
G
V
Y
L
DLP
A
N
V
LAATMEKD
---
EALTTIVKVENPS
P
ALLPCPKS
V
TS
A
ISL
L
AK
A
ER
P
L
I
IL
G
K
G
AAY
S
Q
A
DEQ
L
R
E
FIESAQI
P
FLPM
S
M
AK
G
IL
E
DT
HP
---
--
-
-
L
S
A
AAARSFA
L
A
NAD
V
V
ML
VG
A
R
L
NW
L
LAHGKKG
W
A
A
-
D
T
QF
I
Q
L
DI
E
P
Q
EI
DSNRPIA
V
P
V
VGD
IASS
M
QG
M
L
AE
L
KQNTFTT
PL
V
--
--
W
R
D
ILNIH
K
QQNAQKMHEKLST
D
----------------------------
T
-
-QPLNYFNA
L
SA
VRDV
LRENQDIY
L
V
NE
G
AN
T
L
D
N
A
RN
I
IDMYK
PR
RR
L
D
C
G
--------
TW
G
V
MG
I
G
MG
Y
AIGA
SV
T
S
G
S-P
VV
A
IE
GD
S
AFG
F
SGM
E
IE
T
IC
R
YN
LPV
T
IV
IF
NN
G-
-
G
I
Y
R
G
DGVD
L
SGAGAPSPTDLLHH
-----------
AR
Y
DK
L
M
D
A
F
R
GV
G
YN
V
TTTD
E
LRH
AL
TTGIQS
---
RK
P
TI
I
N
V
V
ID
PA
AGTESGHIT
KLN
P
K
Q
VA
G
fig|316385.7.peg.2562
Escherichia coli str. K-12 substr. DH10B (7-557/558)
IIV
EA
L
KQN
NI
DT
I
Y
G
VV
G
IP
V
TD
M
A
R
H
A
QAE
-
G
-
I
R
Y
I
GF
RHEQ
S
A
GYA
A
A
A
S
G
FLT
Q
K
P
G
I
--
C
LTV
S
A
PG
F
L
N
G
L
T
A
LA
N
A
TV
N
GF
P
M
I
M
ISG
SSDRAI
VDLQ
Q
G
D
YE
E
L
D
QM
--------
NAAKPYA
K
AAF
R
V
NQP
Q
DL
G
IA
L
AR
A
IRV
S
V
S
-
GRPG
G
V
Y
L
DLP
A
N
V
LAATMEKD
---
EALTTIVKVENPS
P
ALLPCPKS
V
TS
A
ISL
L
AK
A
ER
P
L
I
IL
G
K
G
AAY
S
Q
A
DEQ
L
R
E
FIESAQI
P
FLPM
S
M
AK
G
IL
E
DT
HP
---
--
-
-
L
S
A
AAARSFA
L
A
NAD
V
V
ML
VG
A
R
L
NW
L
LAHGKKG
W
A
A
-
D
T
QF
I
Q
L
DI
E
P
Q
EI
DSNRPIA
V
P
V
VGD
IASS
M
QG
M
L
AE
L
KQNTFTT
PL
V
--
--
W
R
D
ILNIH
K
QQNAQKMHEKLST
D
----------------------------
T
-
-QPLNYFNA
L
SA
VRDV
LRENQDIY
L
V
NE
G
AN
T
L
D
N
A
RN
I
IDMYK
PR
RR
L
D
C
G
--------
TW
G
V
MG
I
G
MG
Y
AIGA
SV
T
S
G
S-P
VV
A
IE
GD
S
AFG
F
SGM
E
IE
T
IC
R
YN
LPV
T
IV
IF
NN
G-
-
G
I
Y
R
G
DGVD
L
SGAGAPSPTDLLHH
-----------
AR
Y
DK
L
M
D
A
F
R
GV
G
YN
V
TTTD
E
LRH
AL
TTGIQS
---
RK
P
TI
I
N
V
V
ID
PA
AGTESGHIT
KLN
P
K
Q
VA
G
fig|511693.5.peg.2399
Escherichia coli BL21 (3-553/554)
IIV
EA
L
KQN
NI
DT
I
Y
G
VV
G
IP
V
TD
M
A
R
H
A
QAE
-
G
-
I
R
Y
I
GF
RHEQ
S
A
GYA
A
A
A
S
G
FLT
Q
K
P
G
I
--
C
LTV
S
A
PG
F
L
N
G
L
T
A
LA
N
A
TV
N
GF
P
M
I
M
ISG
SSDRAI
VDLQ
Q
G
D
YE
E
L
D
QM
--------
NAAKPYA
K
AAF
R
V
NQP
Q
DL
G
IA
L
AR
A
IRV
S
V
S
-
GRPG
G
V
Y
L
DLP
A
N
V
LAATMEKD
---
EALTTIVKVENPS
P
ALLPCPKS
V
TS
A
ISL
L
AK
A
ER
P
L
I
IL
G
K
G
AAY
S
Q
A
DEQ
L
R
E
FIESAQI
P
FLPM
S
M
AK
G
IL
E
DT
HP
---
--
-
-
L
S
A
AAARSFA
L
A
NAD
V
V
ML
VG
A
R
L
NW
L
LAHGKKG
W
A
A
-
D
T
QF
I
Q
L
DI
E
P
Q
EI
DSNRPIA
V
P
V
VGD
IASS
M
QG
M
L
AE
L
KQNTFTT
PL
V
--
--
W
R
D
ILNIH
K
QQNAQKMHEKLST
D
----------------------------
T
-
-QPLNYFNA
L
SA
VRDV
LRENQDIY
L
V
NE
G
AN
T
L
D
N
A
RN
I
IDMYK
PR
RR
L
D
C
G
--------
TW
G
V
MG
I
G
MG
Y
AIGA
SV
T
S
G
S-P
VV
A
IE
GD
S
AFG
F
SGM
E
IE
T
IC
R
YN
LPV
T
IV
IF
NN
G-
-
G
I
Y
R
G
DGVD
L
SGAGAPSPTDLLHH
-----------
AR
Y
DK
L
M
D
A
F
R
GV
G
YN
V
TTTD
E
LRH
AL
TTGIQS
---
RK
P
TI
I
N
V
V
ID
PA
AGTESGHIT
KLN
P
K
Q
VA
G
fig|570506.3.peg.5122
Escherichia coli O157:H7 str. FRIK966 (3-553/554)
IIV
EA
L
KQN
NI
DT
I
Y
G
VV
G
IP
V
TD
M
A
R
H
A
QAE
-
G
-
I
R
Y
I
GF
RHEQ
S
A
GYA
A
A
A
S
G
FLT
Q
K
P
G
I
--
C
LTV
S
A
PG
F
L
N
G
L
T
A
LA
N
A
TV
N
GF
P
M
I
M
ISG
SSDRAI
VDLQ
Q
G
D
YE
E
L
D
QM
--------
NAAKPYA
K
AAF
R
V
NQP
Q
DL
G
IA
L
AR
A
IRV
S
V
S
-
GRPG
G
V
Y
L
DLP
A
N
V
LAATMEKD
---
EALTTIVKVENPS
P
ALLPCPKS
V
TS
A
ISL
L
AK
A
ER
P
L
I
IL
G
K
G
AAY
S
Q
A
DEQ
L
R
E
FIESAQI
P
FLPM
S
M
AK
G
IL
E
DT
HP
---
--
-
-
L
S
A
AAARSFA
L
A
NAD
V
V
ML
VG
A
R
L
NW
L
LAHGKKG
W
A
A
-
D
T
QF
I
Q
L
DI
E
P
Q
EI
DSNRPIA
V
P
V
VGD
IASS
M
QG
M
L
AE
L
KQNTFTT
PL
V
--
--
W
R
D
ILNIH
K
QQNAQKMHEKLST
D
----------------------------
T
-
-QPLNYFNA
L
SA
VRDV
LRENQDIY
L
V
NE
G
AN
T
L
D
N
A
RN
I
IDMYK
PR
RR
L
D
C
G
--------
TW
G
V
MG
I
G
MG
Y
AIGA
SV
T
S
G
S-P
VV
A
IE
GD
S
AFG
F
SGM
E
IE
T
IC
R
YN
LPV
T
IV
IF
NN
G-
-
G
I
Y
R
G
DGVD
L
SGAGAPSPTDLLHH
-----------
AR
Y
DK
L
M
D
A
F
R
GV
G
YN
V
TTTD
E
LRH
AL
TTGIQS
---
RK
P
TI
I
N
V
V
ID
PA
AGTESGHIT
KLN
P
K
Q
VA
G
fig|1040638.4.peg.2788
Escherichia coli O104:H4 str. LB226692 (13-563/564)
IIV
EA
L
KQN
NI
DT
I
Y
G
VV
G
IP
V
TD
M
A
R
H
A
QAE
-
G
-
I
R
Y
I
GF
RHEQ
S
A
GYA
A
A
A
S
G
FLT
Q
K
P
G
I
--
C
LTV
S
A
PG
F
L
N
G
L
T
A
LA
N
A
TV
N
GF
P
M
I
M
ISG
SSDRAI
VDLQ
Q
G
D
YE
E
L
D
QM
--------
NAAKPYA
K
AAF
R
V
NQP
Q
DL
G
IA
L
AR
A
IRV
S
V
S
-
GRPG
G
V
Y
L
DLP
A
N
V
LAATMEKD
---
EALTTIVKVENPS
P
ALLPCPKS
V
TS
A
ISL
L
AK
A
ER
P
L
I
IL
G
K
G
AAY
S
Q
A
DEQ
L
R
E
FIESTQI
P
FLPM
S
M
AK
G
IL
E
DT
HP
---
--
-
-
L
S
A
AAARSFA
L
A
NAD
V
V
ML
VG
A
R
L
NW
L
LAHGKKG
W
S
A
-
D
T
QF
I
Q
L
DI
E
P
Q
EI
DSNRPIA
V
P
V
VGD
IASS
M
QG
M
L
AE
L
KQNTFTT
PL
V
--
--
W
R
D
ILNIH
K
QQNAQKMHEKLST
D
----------------------------
T
-
-QPLNYFNA
L
SA
VRDV
LRENQDIY
L
V
NE
G
AN
T
L
D
N
A
RN
I
IDMYK
PR
RR
L
D
C
G
--------
TW
G
V
MG
I
G
MG
Y
AIGA
SV
T
S
G
S-P
VV
A
IE
GD
S
AFG
F
SGM
E
IE
T
IC
R
YN
LPV
T
IV
IF
NN
G-
-
G
I
Y
R
G
DGVD
L
SGAGAPSPTDLLHH
-----------
AR
Y
DK
L
M
D
A
F
R
GV
G
YN
V
TTTD
E
LRH
AL
TTGIQS
---
RK
P
TI
I
N
V
V
ID
PA
AGTESGHIT
KLN
P
K
Q
VA
G
fig|6666666.5357.peg.2390
Escherichia coli TY-2482 (13-563/564)
IIV
EA
L
KQN
NI
DT
I
Y
G
VV
G
IP
V
TD
M
A
R
H
A
QAE
-
G
-
I
R
Y
I
GF
RHEQ
S
A
GYA
A
A
A
S
G
FLT
Q
K
P
G
I
--
C
LTV
S
A
PG
F
L
N
G
L
T
A
LA
N
A
TV
N
GF
P
M
I
M
ISG
SSDRAI
VDLQ
Q
G
D
YE
E
L
D
QM
--------
NAAKPYA
K
AAF
R
V
NQP
Q
DL
G
IA
L
AR
A
IRV
S
V
S
-
GRPG
G
V
Y
L
DLP
A
N
V
LAATMEKD
---
EALTTIVKVENPS
P
ALLPCPKS
V
TS
A
ISL
L
AK
A
ER
P
L
I
IL
G
K
G
AAY
S
Q
A
DEQ
L
R
E
FIESTQI
P
FLPM
S
M
AK
G
IL
E
DT
HP
---
--
-
-
L
S
A
AAARSFA
L
A
NAD
V
V
ML
VG
A
R
L
NW
L
LAHGKKG
W
S
A
-
D
T
QF
I
Q
L
DI
E
P
Q
EI
DSNRPIA
V
P
V
VGD
IASS
M
QG
M
L
AE
L
KQNTFTT
PL
V
--
--
W
R
D
ILNIH
K
QQNAQKMHEKLST
D
----------------------------
T
-
-QPLNYFNA
L
SA
VRDV
LRENQDIY
L
V
NE
G
AN
T
L
D
N
A
RN
I
IDMYK
PR
RR
L
D
C
G
--------
TW
G
V
MG
I
G
MG
Y
AIGA
SV
T
S
G
S-P
VV
A
IE
GD
S
AFG
F
SGM
E
IE
T
IC
R
YN
LPV
T
IV
IF
NN
G-
-
G
I
Y
R
G
DGVD
L
SGAGAPSPTDLLHH
-----------
AR
Y
DK
L
M
D
A
F
R
GV
G
YN
V
TTTD
E
LRH
AL
TTGIQS
---
RK
P
TI
I
N
V
V
ID
PA
AGTESGHIT
KLN
P
K
Q
VA
G
fig|585055.6.peg.2697
Escherichia coli 55989 (13-563/564)
IIV
EA
L
KQN
NI
DT
I
Y
G
VV
G
IP
V
TD
M
A
R
H
A
QAE
-
G
-
I
R
Y
I
GF
RHEQ
S
A
GYA
A
A
A
S
G
FLT
Q
K
P
G
I
--
C
LTV
S
A
PG
F
L
N
G
L
T
A
LA
N
A
TV
N
GF
P
M
I
M
ISG
SSDRAI
VDLQ
Q
G
D
YE
E
L
D
QM
--------
NAAKPYA
K
AAF
R
V
NQP
Q
DL
G
IA
L
AR
A
IRV
S
V
S
-
GRPG
G
V
Y
L
DLP
A
N
V
LAATMEKD
---
EALTTIVKVENPS
P
ALLPCPKS
V
TS
A
ISL
L
AK
A
ER
P
L
I
IL
G
K
G
AAY
S
Q
A
DEQ
L
R
E
FIESTQI
P
FLPM
S
M
AK
G
IL
E
DT
HP
---
--
-
-
L
S
A
AAARSFA
L
A
NAD
V
V
ML
VG
A
R
L
NW
L
LAHGKKG
W
S
A
-
D
T
QF
I
Q
L
DI
E
P
Q
EI
DSNRPIA
V
P
V
VGD
IASS
M
QG
M
L
AE
L
KQNTFTT
PL
V
--
--
W
R
D
ILNIH
K
QQNAQKMHEKLST
D
----------------------------
T
-
-QPLNYFNA
L
SA
VRDV
LRENQDIY
L
V
NE
G
AN
T
L
D
N
A
RN
I
IDMYK
PR
RR
L
D
C
G
--------
TW
G
V
MG
I
G
MG
Y
AIGA
SV
T
S
G
S-P
VV
A
IE
GD
S
AFG
F
SGM
E
IE
T
IC
R
YN
LPV
T
IV
IF
NN
G-
-
G
I
Y
R
G
DGVD
L
SGAGAPSPTDLLHH
-----------
AR
Y
DK
L
M
D
A
F
R
GV
G
YN
V
TTTD
E
LRH
AL
TTGIQS
---
RK
P
TI
I
N
V
V
ID
PA
AGTESGHIT
KLN
P
K
Q
VA
G
fig|585055.8.peg.2702
Escherichia coli 55989 (13-563/564)
IIV
EA
L
KQN
NI
DT
I
Y
G
VV
G
IP
V
TD
M
A
R
H
A
QAE
-
G
-
I
R
Y
I
GF
RHEQ
S
A
GYA
A
A
A
S
G
FLT
Q
K
P
G
I
--
C
LTV
S
A
PG
F
L
N
G
L
T
A
LA
N
A
TV
N
GF
P
M
I
M
ISG
SSDRAI
VDLQ
Q
G
D
YE
E
L
D
QM
--------
NAAKPYA
K
AAF
R
V
NQP
Q
DL
G
IA
L
AR
A
IRV
S
V
S
-
GRPG
G
V
Y
L
DLP
A
N
V
LAATMEKD
---
EALTTIVKVENPS
P
ALLPCPKS
V
TS
A
ISL
L
AK
A
ER
P
L
I
IL
G
K
G
AAY
S
Q
A
DEQ
L
R
E
FIESTQI
P
FLPM
S
M
AK
G
IL
E
DT
HP
---
--
-
-
L
S
A
AAARSFA
L
A
NAD
V
V
ML
VG
A
R
L
NW
L
LAHGKKG
W
S
A
-
D
T
QF
I
Q
L
DI
E
P
Q
EI
DSNRPIA
V
P
V
VGD
IASS
M
QG
M
L
AE
L
KQNTFTT
PL
V
--
--
W
R
D
ILNIH
K
QQNAQKMHEKLST
D
----------------------------
T
-
-QPLNYFNA
L
SA
VRDV
LRENQDIY
L
V
NE
G
AN
T
L
D
N
A
RN
I
IDMYK
PR
RR
L
D
C
G
--------
TW
G
V
MG
I
G
MG
Y
AIGA
SV
T
S
G
S-P
VV
A
IE
GD
S
AFG
F
SGM
E
IE
T
IC
R
YN
LPV
T
IV
IF
NN
G-
-
G
I
Y
R
G
DGVD
L
SGAGAPSPTDLLHH
-----------
AR
Y
DK
L
M
D
A
F
R
GV
G
YN
V
TTTD
E
LRH
AL
TTGIQS
---
RK
P
TI
I
N
V
V
ID
PA
AGTESGHIT
KLN
P
K
Q
VA
G
fig|749537.3.peg.4201
Escherichia coli MS 115-1 (13-563/564)
IIV
EA
L
KQN
NI
DT
I
Y
G
VV
G
IP
V
TD
M
A
R
H
A
QAE
-
G
-
I
R
Y
I
GF
RHEQ
S
A
GYA
A
A
A
S
G
FLT
Q
K
P
G
I
--
C
LTV
S
A
PG
F
L
N
G
L
T
A
LA
N
A
TV
N
GF
P
M
I
M
ISG
SSDRAI
VDLQ
Q
G
D
YE
E
L
D
QM
--------
NAAKPYA
K
AAF
R
V
NQP
Q
DL
G
IA
L
AR
A
IRV
S
V
S
-
GRPG
G
V
Y
L
DLP
A
N
V
LAATMEKD
---
EALTTIVKVENPS
P
ALLPCPKS
V
TS
A
ISL
L
AK
A
ER
P
L
I
IL
G
K
G
AAY
S
Q
A
DEQ
L
R
E
FIESAQI
P
FLPM
S
M
AK
G
IL
E
DT
HP
---
--
-
-
L
S
A
AAARSFA
L
A
NAD
V
V
IL
VG
A
R
L
NW
L
LAHGKKG
W
A
A
-
D
T
QF
I
Q
L
DI
E
P
Q
EI
DSNRPIA
V
P
V
VGD
IASS
M
QG
M
L
AE
L
KQNTFTT
PL
V
--
--
W
R
D
ILNIH
K
QQNAQKMHEKLST
D
----------------------------
T
-
-QPLNYFNA
L
SA
VRDV
LRENQDIY
L
V
NE
G
AN
T
L
D
N
A
RN
I
IDMYK
PR
RR
L
D
C
G
--------
TW
G
V
MG
I
G
MG
Y
AIGA
SV
T
S
G
S-P
VV
A
IE
GD
S
AFG
F
SGM
E
IE
T
IC
R
YN
LPV
T
IV
IF
NN
G-
-
G
I
Y
R
G
DGVD
L
SGAGAPSPTDLLHH
-----------
AR
Y
DK
L
M
D
A
F
R
GV
G
YN
V
TTTD
E
LRH
AL
TTGIQS
---
RK
P
TI
I
N
V
V
ID
PA
AGTESGHIT
KLN
P
K
Q
VA
G
fig|431946.3.peg.2344
Escherichia coli SE15 (13-563/564)
IIV
EA
L
KQN
NI
DT
I
Y
G
VV
G
IP
V
TD
M
A
R
H
A
QAE
-
G
-
I
R
Y
I
GF
RHEQ
S
A
GYA
A
A
A
S
G
FLT
Q
K
P
G
I
--
C
LTV
S
A
PG
F
L
N
G
L
T
A
LA
N
A
TV
N
GF
P
M
I
M
ISG
SSDRAI
VDLQ
Q
G
D
YE
E
L
D
QM
--------
NAAKPYA
K
AAF
R
V
NQP
Q
DL
G
IA
L
AR
A
IRV
S
V
S
-
GRPG
G
V
Y
L
DLP
A
N
V
LAATMEKD
---
EALTTIVKVENPS
P
ALLPCPKS
V
TS
A
ISL
L
AK
A
ER
P
L
I
IL
G
K
G
AAY
S
Q
S
DEQ
L
R
E
FIESAQI
P
FLPM
S
M
AK
G
IL
E
DT
HP
---
--
-
-
L
S
A
AAARSFA
L
A
NAD
V
V
ML
VG
A
R
L
NW
L
LAHGKKG
W
A
A
-
D
T
QF
I
Q
L
DI
E
P
Q
EI
DSNRPIA
V
P
V
VGD
IASS
M
QG
M
L
AE
L
KQNTFTT
PL
V
--
--
W
R
D
ILNIH
K
QQNAQKMHEKLST
D
----------------------------
T
-
-QPLNYFNA
L
SA
VRDV
LRENQDIY
L
V
NE
G
AN
T
L
D
N
A
RN
I
IDMYK
PR
RR
L
D
C
G
--------
TW
G
V
MG
I
G
MG
Y
AIGA
SV
T
S
G
S-P
VV
A
IE
GD
S
AFG
F
SGM
E
IE
T
IC
R
YN
LPV
T
IV
IF
NN
G-
-
G
I
Y
R
G
DGVD
L
SGAGAPSPTDLLHH
-----------
AR
Y
DK
L
M
D
A
F
R
GV
G
YN
V
TTTD
E
LRH
AL
TTGIQS
---
RK
P
TI
I
N
V
V
ID
PA
AGTESGHIT
KLN
P
K
Q
VA
G
fig|656417.3.peg.3058
Escherichia coli M605 (3-553/554)
IIV
EA
L
KQN
NI
DT
I
Y
G
VV
G
IP
V
TD
M
A
R
H
A
QAE
-
G
-
I
R
Y
I
GF
RHEQ
S
A
GYA
A
A
A
S
G
FLT
Q
K
P
G
I
--
C
LTV
S
A
PG
F
L
N
G
L
T
A
LA
N
A
TV
N
GF
P
M
I
M
ISG
SSDRAI
VDLQ
Q
G
D
YE
E
L
D
QM
--------
NAAKPYA
K
AAF
R
V
NQP
Q
DL
G
IA
L
AR
A
IRV
S
V
S
-
GRPG
G
V
Y
L
DLP
A
N
V
LAATMEKD
---
EALTTIVKVENPS
P
ALLPCPKS
V
TS
A
ISL
L
AK
A
ER
P
L
I
IL
G
K
G
AAY
S
Q
S
DEQ
L
R
E
FIESAQI
P
FLPM
S
M
AK
G
IL
E
DT
HP
---
--
-
-
L
S
A
AAARSFA
L
A
NAD
V
V
ML
VG
A
R
L
NW
L
LAHGKKG
W
A
A
-
D
T
QF
I
Q
L
DI
E
P
Q
EI
DSNRPIA
V
P
V
VGD
IASS
M
QG
M
L
AE
L
KQNTFTT
PL
V
--
--
W
R
D
ILNIH
K
QQNAQKMHEKLST
D
----------------------------
T
-
-QPLNYFNA
L
SA
VRDV
LRENQDIY
L
V
NE
G
AN
T
L
D
N
A
RN
I
IDMYK
PR
RR
L
D
C
G
--------
TW
G
V
MG
I
G
MG
Y
AIGA
SV
T
S
G
S-P
VV
A
IE
GD
S
AFG
F
SGM
E
IE
T
IC
R
YN
LPV
T
IV
IF
NN
G-
-
G
I
Y
R
G
DGVD
L
SGAGAPSPTDLLHH
-----------
AR
Y
DK
L
M
D
A
F
R
GV
G
YN
V
TTTD
E
LRH
AL
TTGIQS
---
RK
P
TI
I
N
V
V
ID
PA
AGTESGHIT
KLN
P
K
Q
VA
G
fig|331111.12.peg.2939
Escherichia coli E24377A (13-563/564)
IIV
EA
L
KQN
NI
DT
I
Y
G
VV
G
IP
V
TD
M
A
R
H
A
QAE
-
G
-
I
R
Y
I
GF
RHEQ
S
A
GYA
A
A
A
S
G
FLT
Q
K
P
G
I
--
C
LTV
S
A
PG
F
L
N
G
L
T
A
LA
N
A
TV
N
GF
P
M
I
M
ISG
SSDRAI
VDLQ
Q
G
D
YE
E
L
D
QM
--------
NAAKPYA
K
VAF
R
V
NQP
Q
DL
G
IA
L
AR
A
IRV
S
V
S
-
GRPG
G
V
Y
L
DLP
A
N
V
LAATMEKD
---
EALTTIVKVENPS
P
ALLPCPKS
V
TS
A
ISL
L
AK
A
ER
P
L
I
IL
G
K
G
AAY
S
Q
A
DEQ
L
R
E
FIESTQI
P
FLPM
S
M
AK
G
IL
E
DT
HP
---
--
-
-
L
S
A
AAARSFA
L
A
NAD
V
V
ML
VG
A
R
L
NW
L
LAHGKKG
W
A
A
-
D
T
QF
I
Q
L
DI
E
P
Q
EI
DSNRPIA
V
P
V
VGD
IASS
M
QG
M
L
AE
L
KQNTFTT
PL
V
--
--
W
R
D
ILNIH
K
QQNAQKMHEKLST
D
----------------------------
T
-
-QPLNYFNA
L
SA
VRDV
LRENQDIY
L
V
NE
G
AN
T
L
D
N
A
RN
I
IDMYK
PR
RR
L
D
C
G
--------
TW
G
V
MG
I
G
MG
Y
AIGA
SV
T
S
G
S-P
VV
A
IE
GD
S
AFG
F
SGM
E
IE
T
IC
R
YN
LPV
T
IV
IF
NN
G-
-
G
I
Y
R
G
DGVD
L
SGAGAPSPTDLLHH
-----------
AR
Y
DK
L
M
D
A
F
R
GV
G
YN
V
TTTD
E
LRH
AL
TTGIQS
---
RK
P
TI
I
N
V
V
ID
PA
AGTESGHIT
KLN
P
K
Q
VA
G
fig|331111.3.peg.392
Escherichia coli E24377A (13-563/564)
IIV
EA
L
KQN
NI
DT
I
Y
G
VV
G
IP
V
TD
M
A
R
H
A
QAE
-
G
-
I
R
Y
I
GF
RHEQ
S
A
GYA
A
A
A
S
G
FLT
Q
K
P
G
I
--
C
LTV
S
A
PG
F
L
N
G
L
T
A
LA
N
A
TV
N
GF
P
M
I
M
ISG
SSDRAI
VDLQ
Q
G
D
YE
E
L
D
QM
--------
NAAKPYA
K
VAF
R
V
NQP
Q
DL
G
IA
L
AR
A
IRV
S
V
S
-
GRPG
G
V
Y
L
DLP
A
N
V
LAATMEKD
---
EALTTIVKVENPS
P
ALLPCPKS
V
TS
A
ISL
L
AK
A
ER
P
L
I
IL
G
K
G
AAY
S
Q
A
DEQ
L
R
E
FIESTQI
P
FLPM
S
M
AK
G
IL
E
DT
HP
---
--
-
-
L
S
A
AAARSFA
L
A
NAD
V
V
ML
VG
A
R
L
NW
L
LAHGKKG
W
A
A
-
D
T
QF
I
Q
L
DI
E
P
Q
EI
DSNRPIA
V
P
V
VGD
IASS
M
QG
M
L
AE
L
KQNTFTT
PL
V
--
--
W
R
D
ILNIH
K
QQNAQKMHEKLST
D
----------------------------
T
-
-QPLNYFNA
L
SA
VRDV
LRENQDIY
L
V
NE
G
AN
T
L
D
N
A
RN
I
IDMYK
PR
RR
L
D
C
G
--------
TW
G
V
MG
I
G
MG
Y
AIGA
SV
T
S
G
S-P
VV
A
IE
GD
S
AFG
F
SGM
E
IE
T
IC
R
YN
LPV
T
IV
IF
NN
G-
-
G
I
Y
R
G
DGVD
L
SGAGAPSPTDLLHH
-----------
AR
Y
DK
L
M
D
A
F
R
GV
G
YN
V
TTTD
E
LRH
AL
TTGIQS
---
RK
P
TI
I
N
V
V
ID
PA
AGTESGHIT
KLN
P
K
Q
VA
G
fig|655817.3.peg.2813
Escherichia coli ABU 83972 (13-563/564)
IIV
EA
L
KQN
NI
DT
I
Y
G
VV
G
IP
V
TD
M
A
R
H
A
QAE
-
G
-
I
R
Y
I
GF
RHEQ
S
A
GYA
A
A
A
S
G
FLT
Q
K
P
G
I
--
C
LTV
S
A
PG
F
L
N
G
L
T
A
LA
N
A
TV
N
GF
P
M
I
M
ISG
SSDRAI
VDLQ
Q
G
D
YE
E
L
D
QM
--------
NAAKPYA
K
AAF
R
V
NQP
Q
DL
G
IA
L
AR
A
IRV
S
V
S
-
GRPG
G
V
Y
L
DLP
A
N
V
LAATMEKD
---
EALTTIVKVENPS
P
ALLPCPKS
V
TS
A
ISL
L
AK
A
ER
P
L
I
IL
G
K
G
AAY
S
Q
S
DEQ
L
R
E
FIESAQI
P
FLPM
S
M
AK
G
IL
E
DT
HP
---
--
-
-
L
S
A
AAARSFA
L
A
NAD
V
V
ML
VG
A
R
L
NW
L
LAHGKKG
W
A
A
-
D
T
QF
I
Q
L
DI
E
P
Q
EI
DSNRPIA
V
P
V
VGD
IASS
M
QG
M
L
AE
L
KQNTFTT
PL
V
--
--
W
R
D
ILNIH
K
QQNAQKMHEKLST
D
----------------------------
T
-
-QPLNYFNA
L
GA
VRDV
LRENQDIY
L
V
NE
G
AN
T
L
D
N
A
RN
I
IDMYK
PR
RR
L
D
C
G
--------
TW
G
V
MG
I
G
MG
Y
AIGA
SV
T
S
G
S-P
VV
A
IE
GD
S
AFG
F
SGM
E
IE
T
IC
R
YN
LPV
T
IV
IF
NN
G-
-
G
I
Y
R
G
DGVD
L
SGAGAPSPTDLLHH
-----------
AR
Y
DK
L
M
D
A
F
R
GV
G
YN
V
TTTD
E
LRH
AL
TTGIQS
---
RK
P
TI
I
N
V
V
ID
PA
AGTESGHIT
KLN
P
K
Q
VA
G
fig|199310.1.peg.2834
Escherichia coli CFT073 (13-563/564)
IIV
EA
L
KQN
NI
DT
I
Y
G
VV
G
IP
V
TD
M
A
R
H
A
QAE
-
G
-
I
R
Y
I
GF
RHEQ
S
A
GYA
A
A
A
S
G
FLT
Q
K
P
G
I
--
C
LTV
S
A
PG
F
L
N
G
L
T
A
LA
N
A
TV
N
GF
P
M
I
M
ISG
SSDRAI
VDLQ
Q
G
D
YE
E
L
D
QM
--------
NAAKPYA
K
AAF
R
V
NQP
Q
DL
G
IA
L
AR
A
IRV
S
V
S
-
GRPG
G
V
Y
L
DLP
A
N
V
LAATMEKD
---
EALTTIVKVENPS
P
ALLPCPKS
V
TS
A
ISL
L
AK
A
ER
P
L
I
IL
G
K
G
AAY
S
Q
S
DEQ
L
R
E
FIESAQI
P
FLPM
S
M
AK
G
IL
E
DT
HP
---
--
-
-
L
S
A
AAARSFA
L
A
NAD
V
V
ML
VG
A
R
L
NW
L
LAHGKKG
W
A
A
-
D
T
QF
I
Q
L
DI
E
P
Q
EI
DSNRPIA
V
P
V
VGD
IASS
M
QG
M
L
AE
L
KQNTFTT
PL
V
--
--
W
R
D
ILNIH
K
QQNAQKMHEKLST
D
----------------------------
T
-
-QPLNYFNA
L
GA
VRDV
LRENQDIY
L
V
NE
G
AN
T
L
D
N
A
RN
I
IDMYK
PR
RR
L
D
C
G
--------
TW
G
V
MG
I
G
MG
Y
AIGA
SV
T
S
G
S-P
VV
A
IE
GD
S
AFG
F
SGM
E
IE
T
IC
R
YN
LPV
T
IV
IF
NN
G-
-
G
I
Y
R
G
DGVD
L
SGAGAPSPTDLLHH
-----------
AR
Y
DK
L
M
D
A
F
R
GV
G
YN
V
TTTD
E
LRH
AL
TTGIQS
---
RK
P
TI
I
N
V
V
ID
PA
AGTESGHIT
KLN
P
K
Q
VA
G
fig|656440.3.peg.2432
Escherichia coli TA206 (13-563/564)
IIV
EA
L
KQN
NI
DT
I
Y
G
VV
G
IP
V
TD
M
A
R
H
A
QAE
-
G
-
I
R
Y
I
GF
RHEQ
S
A
GYA
A
A
A
S
G
FLT
Q
K
P
G
I
--
C
LTV
S
A
PG
F
L
N
G
L
T
A
LA
N
A
TV
N
GF
P
M
I
M
ISG
SSDRAI
VDLQ
Q
G
D
YE
E
L
D
QM
--------
NAAKPYA
K
AAF
R
V
NQP
Q
DL
G
IA
L
AR
A
IRV
S
V
S
-
GRPG
G
V
Y
L
DLP
A
N
V
LAATMEKD
---
EALTTIVKVENPS
P
ALLPCPKS
V
TS
A
ISL
L
AK
A
ER
P
L
I
IL
G
K
G
AAY
S
Q
S
DEQ
L
R
E
FIESAQI
P
FLPM
S
M
AK
G
IL
E
DT
HP
---
--
-
-
L
S
A
AAARSFA
L
A
NAD
V
V
ML
VG
A
R
L
NW
L
LAHGKKG
W
A
A
-
D
T
QF
I
Q
L
DI
E
P
Q
EI
DSNRPIA
V
P
V
VGD
IASS
M
QG
M
L
AE
L
KQNTFTT
PL
V
--
--
W
R
D
ILNIH
K
QQNAQKMHEKLST
D
----------------------------
T
-
-QPLNYFNA
L
GA
VRDV
LRENQDIY
L
V
NE
G
AN
T
L
D
N
A
RN
I
IDMYK
PR
RR
L
D
C
G
--------
TW
G
V
MG
I
G
MG
Y
AIGA
SV
T
S
G
S-P
VV
A
IE
GD
S
AFG
F
SGM
E
IE
T
IC
R
YN
LPV
T
IV
IF
NN
G-
-
G
I
Y
R
G
DGVD
L
SGAGAPSPTDLLHH
-----------
AR
Y
DK
L
M
D
A
F
R
GV
G
YN
V
TTTD
E
LRH
AL
TTGIQS
---
RK
P
TI
I
N
V
V
ID
PA
AGTESGHIT
KLN
P
K
Q
VA
G
fig|525281.3.peg.4168
Escherichia coli 83972 (3-553/554)
IIV
EA
L
KQN
NI
DT
I
Y
G
VV
G
IP
V
TD
M
A
R
H
A
QAE
-
G
-
I
R
Y
I
GF
RHEQ
S
A
GYA
A
A
A
S
G
FLT
Q
K
P
G
I
--
C
LTV
S
A
PG
F
L
N
G
L
T
A
LA
N
A
TV
N
GF
P
M
I
M
ISG
SSDRAI
VDLQ
Q
G
D
YE
E
L
D
QM
--------
NAAKPYA
K
AAF
R
V
NQP
Q
DL
G
IA
L
AR
A
IRV
S
V
S
-
GRPG
G
V
Y
L
DLP
A
N
V
LAATMEKD
---
EALTTIVKVENPS
P
ALLPCPKS
V
TS
A
ISL
L
AK
A
ER
P
L
I
IL
G
K
G
AAY
S
Q
S
DEQ
L
R
E
FIESAQI
P
FLPM
S
M
AK
G
IL
E
DT
HP
---
--
-
-
L
S
A
AAARSFA
L
A
NAD
V
V
ML
VG
A
R
L
NW
L
LAHGKKG
W
A
A
-
D
T
QF
I
Q
L
DI
E
P
Q
EI
DSNRPIA
V
P
V
VGD
IASS
M
QG
M
L
AE
L
KQNTFTT
PL
V
--
--
W
R
D
ILNIH
K
QQNAQKMHEKLST
D
----------------------------
T
-
-QPLNYFNA
L
GA
VRDV
LRENQDIY
L
V
NE
G
AN
T
L
D
N
A
RN
I
IDMYK
PR
RR
L
D
C
G
--------
TW
G
V
MG
I
G
MG
Y
AIGA
SV
T
S
G
S-P
VV
A
IE
GD
S
AFG
F
SGM
E
IE
T
IC
R
YN
LPV
T
IV
IF
NN
G-
-
G
I
Y
R
G
DGVD
L
SGAGAPSPTDLLHH
-----------
AR
Y
DK
L
M
D
A
F
R
GV
G
YN
V
TTTD
E
LRH
AL
TTGIQS
---
RK
P
TI
I
N
V
V
ID
PA
AGTESGHIT
KLN
P
K
Q
VA
G
fig|199310.4.peg.2743
Escherichia coli CFT073 (3-553/554)
IIV
EA
L
KQN
NI
DT
I
Y
G
VV
G
IP
V
TD
M
A
R
H
A
QAE
-
G
-
I
R
Y
I
GF
RHEQ
S
A
GYA
A
A
A
S
G
FLT
Q
K
P
G
I
--
C
LTV
S
A
PG
F
L
N
G
L
T
A
LA
N
A
TV
N
GF
P
M
I
M
ISG
SSDRAI
VDLQ
Q
G
D
YE
E
L
D
QM
--------
NAAKPYA
K
AAF
R
V
NQP
Q
DL
G
IA
L
AR
A
IRV
S
V
S
-
GRPG
G
V
Y
L
DLP
A
N
V
LAATMEKD
---
EALTTIVKVENPS
P
ALLPCPKS
V
TS
A
ISL
L
AK
A
ER
P
L
I
IL
G
K
G
AAY
S
Q
S
DEQ
L
R
E
FIESAQI
P
FLPM
S
M
AK
G
IL
E
DT
HP
---
--
-
-
L
S
A
AAARSFA
L
A
NAD
V
V
ML
VG
A
R
L
NW
L
LAHGKKG
W
A
A
-
D
T
QF
I
Q
L
DI
E
P
Q
EI
DSNRPIA
V
P
V
VGD
IASS
M
QG
M
L
AE
L
KQNTFTT
PL
V
--
--
W
R
D
ILNIH
K
QQNAQKMHEKLST
D
----------------------------
T
-
-QPLNYFNA
L
GA
VRDV
LRENQDIY
L
V
NE
G
AN
T
L
D
N
A
RN
I
IDMYK
PR
RR
L
D
C
G
--------
TW
G
V
MG
I
G
MG
Y
AIGA
SV
T
S
G
S-P
VV
A
IE
GD
S
AFG
F
SGM
E
IE
T
IC
R
YN
LPV
T
IV
IF
NN
G-
-
G
I
Y
R
G
DGVD
L
SGAGAPSPTDLLHH
-----------
AR
Y
DK
L
M
D
A
F
R
GV
G
YN
V
TTTD
E
LRH
AL
TTGIQS
---
RK
P
TI
I
N
V
V
ID
PA
AGTESGHIT
KLN
P
K
Q
VA
G
fig|749546.3.peg.2796
Escherichia coli MS 185-1 (3-553/554)
IIV
EA
L
KQN
NI
DT
I
Y
G
VV
G
IP
V
TD
M
A
R
H
A
QAE
-
G
-
I
R
Y
I
GF
RHEQ
S
A
GYA
A
A
A
S
G
FLT
Q
K
P
G
I
--
C
LTV
S
A
PG
F
L
N
G
L
T
A
LA
N
A
TV
N
GF
P
M
I
M
ISG
SSDRAI
VDLQ
Q
G
D
YE
E
L
D
QM
--------
NAAKPYA
K
AAF
R
V
NQP
Q
DL
G
IA
L
AR
A
IRV
S
V
S
-
GRPG
G
V
Y
L
DLP
A
N
V
LAATMEKD
---
EALTTIVKVENPS
P
ALLPCPKS
V
TS
A
ISL
L
AK
A
ER
P
L
I
IL
G
K
G
AAY
S
Q
S
DEQ
L
R
E
FIESAQI
P
FLPM
S
M
AK
G
IL
E
DT
HP
---
--
-
-
L
S
A
AAARSFA
L
A
NAD
V
V
ML
VG
A
R
L
NW
L
LAHGKKG
W
A
A
-
D
T
QF
I
Q
L
DI
E
P
Q
EI
DSNRPIA
V
P
V
VGD
IASS
M
QG
M
L
AE
L
KQNTFTT
PL
V
--
--
W
R
D
ILNIH
K
QQNAQKMHEKLST
D
----------------------------
T
-
-QPLNYFNA
L
GA
VRDV
LRENQDIY
L
V
NE
G
AN
T
L
D
N
A
RN
I
IDMYK
PR
RR
L
D
C
G
--------
TW
G
V
MG
I
G
MG
Y
AIGA
SV
T
S
G
S-P
VV
A
IE
GD
S
AFG
F
SGM
E
IE
T
IC
R
YN
LPV
T
IV
IF
NN
G-
-
G
I
Y
R
G
DGVD
L
SGAGAPSPTDLLHH
-----------
AR
Y
DK
L
M
D
A
F
R
GV
G
YN
V
TTTD
E
LRH
AL
TTGIQS
---
RK
P
TI
I
N
V
V
ID
PA
AGTESGHIT
KLN
P
K
Q
VA
G
fig|749528.3.peg.2708
Escherichia coli MS 45-1 (3-553/554)
IIV
EA
L
KQN
NI
DT
I
Y
G
VV
G
IP
V
TD
M
A
R
H
A
QAE
-
G
-
I
R
Y
I
GF
RHEQ
S
A
GYA
A
A
A
S
G
FLT
Q
K
P
G
I
--
C
LTV
S
A
PG
F
L
N
G
L
T
A
LA
N
A
TV
N
GF
P
M
I
M
ISG
SSDRAI
VDLQ
Q
G
D
YE
E
L
D
QM
--------
NAAKPYA
K
AAF
R
V
NQP
Q
DL
G
IA
L
AR
A
IRV
S
V
S
-
GRPG
G
V
Y
L
DLP
A
N
V
LAATMEKD
---
EALTTIVKVENPS
P
ALLPCPKS
V
TS
A
ISL
L
AK
A
ER
P
L
I
IL
G
K
G
AAY
S
Q
S
DEQ
L
R
E
FIESAQI
P
FLPM
S
M
AK
G
IL
E
DT
HP
---
--
-
-
L
S
A
AAARSFA
L
A
NAD
V
V
ML
VG
A
R
L
NW
L
LAHGKKG
W
A
A
-
D
T
QF
I
Q
L
DI
E
P
Q
EI
DSNRPIA
V
P
V
VGD
IASS
M
QG
M
L
AE
L
KQNTFTT
PL
V
--
--
W
R
D
ILNIH
K
QQNAQKMHEKLST
D
----------------------------
T
-
-QPLNYFNA
L
GA
VRDV
LRENQDIY
L
V
NE
G
AN
T
L
D
N
A
RN
I
IDMYK
PR
RR
L
D
C
G
--------
TW
G
V
MG
I
G
MG
Y
AIGA
SV
T
S
G
S-P
VV
A
IE
GD
S
AFG
F
SGM
E
IE
T
IC
R
YN
LPV
T
IV
IF
NN
G-
-
G
I
Y
R
G
DGVD
L
SGAGAPSPTDLLHH
-----------
AR
Y
DK
L
M
D
A
F
R
GV
G
YN
V
TTTD
E
LRH
AL
TTGIQS
---
RK
P
TI
I
N
V
V
ID
PA
AGTESGHIT
KLN
P
K
Q
VA
G
fig|685038.3.peg.2421
Escherichia coli O83:H1 str. NRG 857C (3-553/554)
IIV
EA
L
KQN
NI
DT
I
Y
G
VV
G
IP
V
TD
M
A
R
H
A
QAE
-
G
-
I
R
Y
I
GF
RHEQ
S
A
GYA
A
A
A
S
G
FLT
Q
K
P
G
I
--
C
LTV
S
A
PG
F
L
N
G
L
T
A
LA
N
A
TV
N
GF
P
M
I
M
ISG
SSDRAI
VDLQ
Q
G
D
YE
E
L
D
QM
--------
NAAKPYA
K
AAF
R
V
NQP
Q
DL
G
IA
L
AR
A
IRV
S
V
S
-
GRPG
G
V
Y
L
DLP
A
N
V
LAATMEKD
---
EALTTIVKVENPS
P
ALLPCPKS
V
TS
A
ISL
L
AK
A
ER
P
L
I
IL
G
K
G
AAY
S
Q
S
DEQ
L
R
E
FIESAQI
P
FLPM
S
M
AK
G
IL
E
DT
HP
---
--
-
-
L
S
A
AAARSFA
L
A
NAD
V
V
ML
VG
A
R
L
NW
L
LAHGKKG
W
A
A
-
D
T
QF
I
Q
L
DI
E
P
Q
EI
DSNRPIA
V
P
V
VGD
IASS
M
QG
M
L
AE
L
KQNTFTT
PL
V
--
--
W
R
D
ILNIH
K
QQNAQKMHEKLST
D
----------------------------
T
-
-QPLNYFNA
L
GA
VRDV
LRENQDIY
L
V
NE
G
AN
T
L
D
N
A
RN
I
IDMYK
PR
RR
L
D
C
G
--------
TW
G
V
MG
I
G
MG
Y
AIGA
SV
T
S
G
S-P
VV
A
IE
GD
S
AFG
F
SGM
E
IE
T
IC
R
YN
LPV
T
IV
IF
NN
G-
-
G
I
Y
R
G
DGVD
L
SGAGAPSPTDLLHH
-----------
AR
Y
DK
L
M
D
A
F
R
GV
G
YN
V
TTTD
E
LRH
AL
TTGIQS
---
RK
P
TI
I
N
V
V
ID
PA
AGTESGHIT
KLN
P
K
Q
VA
G
fig|749527.3.peg.1701
Escherichia coli MS 21-1 (13-563/564)
IIV
EA
L
KQN
NI
DT
I
Y
G
VV
G
IP
V
TD
M
A
R
H
A
QAE
-
G
-
I
R
Y
I
GF
RHEQ
S
A
GYA
A
A
A
S
G
FLT
Q
K
P
G
I
--
C
LTV
S
A
PG
F
L
N
G
L
T
A
LA
N
A
TV
N
GF
P
M
I
M
ISG
SSDRAI
VDLQ
Q
G
D
YE
E
L
D
QM
--------
NAAKPYA
K
AAF
R
V
NQP
Q
DL
G
IA
L
AR
A
IRV
S
V
S
-
GRPG
G
V
Y
L
DLP
A
N
V
LAATMEKD
---
EALTTIVKVENPS
P
ALLPCPKS
V
TS
A
ISL
L
AK
A
ER
P
L
I
IL
G
K
G
AAY
S
Q
S
DEQ
L
R
E
FIESAQI
P
FLPM
S
M
AK
G
IL
E
DT
HP
---
--
-
-
L
S
A
AAARSFA
L
A
NAD
V
V
ML
VG
A
R
L
NW
L
LAHGKKG
W
A
A
-
D
T
QF
I
Q
L
DI
E
P
Q
EI
DSNRPIA
V
P
V
VGD
IASS
M
QG
M
L
AE
L
KQNTFTT
PL
V
--
--
W
R
D
ILNIH
K
QQNAQKMHEKLST
D
----------------------------
T
-
-QPLNYFNA
L
SA
M
RDV
LRENQDIY
L
V
NE
G
AN
T
L
D
N
A
RN
I
IDMYK
PR
RR
L
D
C
G
--------
TW
G
V
MG
I
G
MG
Y
AIGA
SV
T
S
G
S-P
VV
A
IE
GD
S
AFG
F
SGM
E
IE
T
IC
R
YN
LPV
T
IV
IF
NN
G-
-
G
I
Y
R
G
DGVD
L
SGAGAPSPTDLLHH
-----------
AR
Y
DK
L
M
D
A
F
R
GV
G
YN
V
TTTD
E
LRH
AL
TTGIQS
---
RK
P
TI
I
N
V
V
ID
PA
AGTESGHIT
KLN
P
K
Q
VA
G
fig|585397.7.peg.2828
Escherichia coli ED1a (13-563/564)
IIV
EA
L
KQN
NI
DT
I
Y
G
VV
G
IP
V
TD
M
A
R
H
A
QAE
-
G
-
I
R
Y
I
GF
RHEQ
S
A
GYA
A
A
A
S
G
FLT
Q
K
P
G
I
--
C
LTV
S
A
PG
F
L
N
G
L
T
A
LA
N
A
TV
N
GF
P
M
I
M
ISG
SSDRAI
VDLQ
Q
G
D
YE
E
L
D
QM
--------
NAAKPYA
K
AAF
R
V
NQP
Q
DL
G
IA
L
AR
A
IRV
S
V
S
-
GRPG
G
V
Y
L
DLP
A
N
V
LAATMEKD
---
EALTTIVKVENPS
P
ALLPCPKS
V
TS
A
ISL
L
AK
A
ER
P
L
I
IL
G
K
G
AAY
S
Q
S
DEQ
L
R
E
FIESAQI
P
FLPM
S
M
AK
G
IL
E
DT
HP
---
--
-
-
L
S
A
AAARSFA
L
A
NAD
V
V
ML
VG
A
R
L
NW
L
LAHGKKG
W
A
A
-
E
T
QF
I
Q
L
DI
E
P
Q
EI
DSNRPIA
V
P
V
VGD
IASS
M
QG
M
L
AE
L
KQNTFTT
PL
V
--
--
W
R
D
ILNIH
K
QQNAQKMHEKLST
D
----------------------------
T
-
-QPLNYFNA
L
SA
VRDV
LRENQDIY
L
V
NE
G
AN
T
L
D
N
A
RN
I
IDMYK
PR
RR
L
D
C
G
--------
TW
G
V
MG
I
G
MG
Y
AIGA
SV
T
S
G
S-P
VV
A
IE
GD
S
AFG
F
SGM
E
IE
T
IC
R
YN
LPV
T
IV
IF
NN
G-
-
G
I
Y
R
G
DGVD
L
SGAGAPSPTDLLHH
-----------
AR
Y
DK
L
M
D
A
F
R
GV
G
YN
V
TTTD
E
LRH
AL
TTGIQS
---
RK
P
TI
I
N
V
V
ID
PA
AGTESGHIT
KLN
P
K
Q
VA
G
fig|585397.9.peg.2825
Escherichia coli ED1a (13-563/564)
IIV
EA
L
KQN
NI
DT
I
Y
G
VV
G
IP
V
TD
M
A
R
H
A
QAE
-
G
-
I
R
Y
I
GF
RHEQ
S
A
GYA
A
A
A
S
G
FLT
Q
K
P
G
I
--
C
LTV
S
A
PG
F
L
N
G
L
T
A
LA
N
A
TV
N
GF
P
M
I
M
ISG
SSDRAI
VDLQ
Q
G
D
YE
E
L
D
QM
--------
NAAKPYA
K
AAF
R
V
NQP
Q
DL
G
IA
L
AR
A
IRV
S
V
S
-
GRPG
G
V
Y
L
DLP
A
N
V
LAATMEKD
---
EALTTIVKVENPS
P
ALLPCPKS
V
TS
A
ISL
L
AK
A
ER
P
L
I
IL
G
K
G
AAY
S
Q
S
DEQ
L
R
E
FIESAQI
P
FLPM
S
M
AK
G
IL
E
DT
HP
---
--
-
-
L
S
A
AAARSFA
L
A
NAD
V
V
ML
VG
A
R
L
NW
L
LAHGKKG
W
A
A
-
E
T
QF
I
Q
L
DI
E
P
Q
EI
DSNRPIA
V
P
V
VGD
IASS
M
QG
M
L
AE
L
KQNTFTT
PL
V
--
--
W
R
D
ILNIH
K
QQNAQKMHEKLST
D
----------------------------
T
-
-QPLNYFNA
L
SA
VRDV
LRENQDIY
L
V
NE
G
AN
T
L
D
N
A
RN
I
IDMYK
PR
RR
L
D
C
G
--------
TW
G
V
MG
I
G
MG
Y
AIGA
SV
T
S
G
S-P
VV
A
IE
GD
S
AFG
F
SGM
E
IE
T
IC
R
YN
LPV
T
IV
IF
NN
G-
-
G
I
Y
R
G
DGVD
L
SGAGAPSPTDLLHH
-----------
AR
Y
DK
L
M
D
A
F
R
GV
G
YN
V
TTTD
E
LRH
AL
TTGIQS
---
RK
P
TI
I
N
V
V
ID
PA
AGTESGHIT
KLN
P
K
Q
VA
G
fig|562.376.peg.4286
Escherichia coli WV_060327 (13-563/564)
IIV
EA
L
KQN
NI
DT
I
Y
G
VV
G
IP
V
TD
M
A
R
H
A
QAE
-
G
-
I
R
Y
I
GF
RHEQ
S
A
GYA
A
A
A
S
G
FLT
Q
K
P
G
I
--
C
LTV
S
A
PG
F
L
N
G
L
T
A
LA
N
A
TV
N
GF
P
M
I
M
ISG
SSDRAI
VDLQ
Q
G
D
YE
E
L
D
QM
--------
NAAKPYA
K
AAF
R
V
NQP
Q
DL
G
IA
L
AR
A
IRV
S
V
S
-
GRPG
G
V
Y
L
DLP
A
N
V
LAATMEKD
---
EALTTIVKVENPS
P
ALLPCPKS
V
TS
A
ISL
L
AK
A
ER
P
L
I
IL
G
K
G
AAY
S
Q
S
DEQ
L
R
E
FIESAQI
P
FLPM
S
M
AK
G
IL
E
DT
HP
---
--
-
-
L
S
A
AAARSFA
L
A
NAD
V
V
ML
VG
A
R
L
NW
L
LAHGKKG
W
A
A
-
E
T
QF
I
Q
L
DI
E
P
Q
EI
DSNRPIA
V
P
V
VGD
IASS
M
QG
M
L
AE
L
KQNTFTT
PL
V
--
--
W
R
D
ILNIH
K
QQNAQKMHEKLST
D
----------------------------
T
-
-QPLNYFNA
L
SA
VRDV
LRENQDIY
L
V
NE
G
AN
T
L
D
N
A
RN
I
IDMYK
PR
RR
L
D
C
G
--------
TW
G
V
MG
I
G
MG
Y
AIGA
SV
T
S
G
S-P
VV
A
IE
GD
S
AFG
F
SGM
E
IE
T
IC
R
YN
LPV
T
IV
IF
NN
G-
-
G
I
Y
R
G
DGVD
L
SGAGAPSPTDLLHH
-----------
AR
Y
DK
L
M
D
A
F
R
GV
G
YN
V
TTTD
E
LRH
AL
TTGIQS
---
RK
P
TI
I
N
V
V
ID
PA
AGTESGHIT
KLN
P
K
Q
VA
G
fig|753642.3.peg.2724
Escherichia coli NC101 (3-553/554)
IIV
EA
L
KQN
NI
DT
I
Y
G
VV
G
IP
V
TD
M
A
R
H
A
QAE
-
G
-
I
R
Y
I
GF
RHEQ
S
A
GYA
A
A
A
S
G
FLT
Q
K
P
G
I
--
C
LTV
S
A
PG
F
L
N
G
L
T
A
LA
N
A
TV
N
GF
P
M
I
M
ISG
SSDRAI
VDLQ
Q
G
D
YE
E
L
D
QM
--------
NAAKPYA
K
AAF
R
V
NQP
Q
DL
G
IA
L
AR
A
IRV
S
V
S
-
GRPG
G
V
Y
L
DLP
A
N
V
LAATMEKD
---
EALTTIVKVENPS
P
ALLPCPKS
V
TS
A
ISL
L
AK
A
ER
P
L
I
IL
G
K
G
AAY
S
Q
S
DEQ
L
R
E
FIESAQI
P
FLPM
S
M
AK
G
IL
E
DT
HP
---
--
-
-
L
S
A
AAARSFA
L
A
NAD
V
V
ML
VG
A
R
L
NW
L
LAHGKKG
W
A
A
-
E
T
QF
I
Q
L
DI
E
P
Q
EI
DSNRPIA
V
P
V
VGD
IASS
M
QG
M
L
AE
L
KQNTFTT
PL
V
--
--
W
R
D
ILNIH
K
QQNAQKMHEKLST
D
----------------------------
T
-
-QPLNYFNA
L
SA
VRDV
LRENQDIY
L
V
NE
G
AN
T
L
D
N
A
RN
I
IDMYK
PR
RR
L
D
C
G
--------
TW
G
V
MG
I
G
MG
Y
AIGA
SV
T
S
G
S-P
VV
A
IE
GD
S
AFG
F
SGM
E
IE
T
IC
R
YN
LPV
T
IV
IF
NN
G-
-
G
I
Y
R
G
DGVD
L
SGAGAPSPTDLLHH
-----------
AR
Y
DK
L
M
D
A
F
R
GV
G
YN
V
TTTD
E
LRH
AL
TTGIQS
---
RK
P
TI
I
N
V
V
ID
PA
AGTESGHIT
KLN
P
K
Q
VA
G
fig|340186.3.peg.2947
Escherichia coli E110019 (13-563/564)
IIV
EA
L
KQN
NI
DT
I
Y
G
VV
G
IP
V
TD
M
A
R
H
A
QAE
-
G
-
I
R
Y
I
GF
RHEQ
S
A
GYA
A
A
A
S
G
FLT
Q
K
P
G
I
--
C
LTV
S
A
PG
F
L
N
G
L
T
A
LA
N
A
TV
N
GF
P
I
I
M
ISG
SSDRAI
VDLQ
Q
G
D
YE
E
L
D
QM
--------
NAAKPYA
K
AAF
R
V
NQP
Q
DL
G
IA
L
AR
A
IRV
S
V
S
-
GRPG
G
V
Y
L
DLP
A
N
V
LAATMEKD
---
EALTTIVKVENPS
P
ALLPCPKS
V
TS
A
ISL
L
AK
A
ER
P
L
I
IL
G
K
G
AAY
S
Q
A
DEQ
L
R
E
FIESTQI
P
FLPM
S
M
AK
G
IL
E
DT
HP
---
--
-
-
L
S
A
AAARSFA
L
A
NAD
V
V
ML
VG
A
R
L
NW
L
LAHGKKG
W
A
A
-
D
T
QF
I
Q
L
DI
E
P
Q
EI
DSNRPIA
V
P
V
VGD
IASS
M
QG
M
L
AE
L
KQNTFTT
PL
V
--
--
W
R
D
ILNIH
K
QQNAQKMHEKLST
D
----------------------------
T
-
-QPLNYFNA
L
SA
VRDV
LRENQDIY
L
V
NE
G
AN
T
L
D
N
A
RN
I
IDMYK
PR
RR
L
D
C
G
--------
TW
G
V
MG
I
G
MG
Y
AIGA
SV
T
S
G
S-P
VV
A
IE
GD
S
AFG
F
SGM
E
IE
T
IC
R
YN
LPV
T
IV
IF
NN
G-
-
G
I
Y
R
G
DGVD
L
SGAGAPSPTDLLHH
-----------
AR
Y
DK
L
M
D
A
F
R
GV
G
YN
V
TTTV
E
LRH
AL
TTGIQS
---
RK
P
TI
I
N
V
V
ID
PA
AGTESGHIT
KLN
P
K
Q
VA
G
fig|340186.5.peg.3063
Escherichia coli E110019 (13-563/564)
IIV
EA
L
KQN
NI
DT
I
Y
G
VV
G
IP
V
TD
M
A
R
H
A
QAE
-
G
-
I
R
Y
I
GF
RHEQ
S
A
GYA
A
A
A
S
G
FLT
Q
K
P
G
I
--
C
LTV
S
A
PG
F
L
N
G
L
T
A
LA
N
A
TV
N
GF
P
I
I
M
ISG
SSDRAI
VDLQ
Q
G
D
YE
E
L
D
QM
--------
NAAKPYA
K
AAF
R
V
NQP
Q
DL
G
IA
L
AR
A
IRV
S
V
S
-
GRPG
G
V
Y
L
DLP
A
N
V
LAATMEKD
---
EALTTIVKVENPS
P
ALLPCPKS
V
TS
A
ISL
L
AK
A
ER
P
L
I
IL
G
K
G
AAY
S
Q
A
DEQ
L
R
E
FIESTQI
P
FLPM
S
M
AK
G
IL
E
DT
HP
---
--
-
-
L
S
A
AAARSFA
L
A
NAD
V
V
ML
VG
A
R
L
NW
L
LAHGKKG
W
A
A
-
D
T
QF
I
Q
L
DI
E
P
Q
EI
DSNRPIA
V
P
V
VGD
IASS
M
QG
M
L
AE
L
KQNTFTT
PL
V
--
--
W
R
D
ILNIH
K
QQNAQKMHEKLST
D
----------------------------
T
-
-QPLNYFNA
L
SA
VRDV
LRENQDIY
L
V
NE
G
AN
T
L
D
N
A
RN
I
IDMYK
PR
RR
L
D
C
G
--------
TW
G
V
MG
I
G
MG
Y
AIGA
SV
T
S
G
S-P
VV
A
IE
GD
S
AFG
F
SGM
E
IE
T
IC
R
YN
LPV
T
IV
IF
NN
G-
-
G
I
Y
R
G
DGVD
L
SGAGAPSPTDLLHH
-----------
AR
Y
DK
L
M
D
A
F
R
GV
G
YN
V
TTTV
E
LRH
AL
TTGIQS
---
RK
P
TI
I
N
V
V
ID
PA
AGTESGHIT
KLN
P
K
Q
VA
G
fig|362663.8.peg.2427
Escherichia coli 536 (13-563/564)
IIV
EA
L
KQN
NI
DT
I
Y
G
VV
G
IP
V
TD
M
A
R
H
A
QAE
-
G
-
I
R
Y
I
GF
RHEQ
S
A
GYA
A
A
A
S
G
FLT
Q
K
P
G
I
--
C
LTV
S
A
PG
F
L
N
G
L
T
A
LA
N
A
TV
N
GF
P
M
I
M
ISG
SSDRAI
VDLQ
Q
G
D
YE
E
L
D
QM
--------
NAAKPYA
K
AAF
R
V
NQP
Q
DL
G
IA
L
AR
A
IRV
S
V
S
-
GRPG
G
V
Y
L
DLP
A
N
V
LAATMEKD
---
EALTTIVKVENPS
P
ALLPCPKS
V
TS
A
ISL
L
AK
A
ER
P
L
I
IL
G
K
G
AAY
S
Q
S
DEQ
L
R
E
FIESAQI
P
FLPM
S
M
AK
G
IL
E
DT
HP
---
--
-
-
L
S
A
AAARSFA
L
A
NAD
V
V
ML
VG
A
R
L
NW
L
LAHGKKG
W
A
A
-
D
T
QF
I
Q
L
DI
E
P
Q
EI
DSNRPIA
V
P
V
VGD
IASS
M
QG
M
L
AE
L
KQNTFTT
PL
V
--
--
W
R
D
ILNIH
K
QQNAQKMHEKLST
D
----------------------------
T
-
-QPLNYFNA
L
SA
VRDV
LRENQDIY
L
V
NE
G
AN
T
L
D
N
A
RN
I
IDMYK
PR
RR
L
D
C
G
--------
TW
G
V
MG
I
G
MG
Y
AIGA
SV
T
S
G
S-P
VV
A
IE
GD
S
AFG
F
SGM
E
IE
T
IC
R
YN
LPV
T
IV
IF
NN
G-
-
G
I
Y
R
G
DGVD
L
SGAGAPSPTDLLHH
-----------
AR
Y
DK
L
M
D
A
F
R
GL
G
YN
V
TTTD
E
LRH
AL
TTGIQS
---
RK
P
TI
I
N
V
V
ID
PA
AGTESGHIT
KLN
P
K
Q
VA
G
fig|362663.9.peg.2432
Escherichia coli 536 (13-563/564)
IIV
EA
L
KQN
NI
DT
I
Y
G
VV
G
IP
V
TD
M
A
R
H
A
QAE
-
G
-
I
R
Y
I
GF
RHEQ
S
A
GYA
A
A
A
S
G
FLT
Q
K
P
G
I
--
C
LTV
S
A
PG
F
L
N
G
L
T
A
LA
N
A
TV
N
GF
P
M
I
M
ISG
SSDRAI
VDLQ
Q
G
D
YE
E
L
D
QM
--------
NAAKPYA
K
AAF
R
V
NQP
Q
DL
G
IA
L
AR
A
IRV
S
V
S
-
GRPG
G
V
Y
L
DLP
A
N
V
LAATMEKD
---
EALTTIVKVENPS
P
ALLPCPKS
V
TS
A
ISL
L
AK
A
ER
P
L
I
IL
G
K
G
AAY
S
Q
S
DEQ
L
R
E
FIESAQI
P
FLPM
S
M
AK
G
IL
E
DT
HP
---
--
-
-
L
S
A
AAARSFA
L
A
NAD
V
V
ML
VG
A
R
L
NW
L
LAHGKKG
W
A
A
-
D
T
QF
I
Q
L
DI
E
P
Q
EI
DSNRPIA
V
P
V
VGD
IASS
M
QG
M
L
AE
L
KQNTFTT
PL
V
--
--
W
R
D
ILNIH
K
QQNAQKMHEKLST
D
----------------------------
T
-
-QPLNYFNA
L
SA
VRDV
LRENQDIY
L
V
NE
G
AN
T
L
D
N
A
RN
I
IDMYK
PR
RR
L
D
C
G
--------
TW
G
V
MG
I
G
MG
Y
AIGA
SV
T
S
G
S-P
VV
A
IE
GD
S
AFG
F
SGM
E
IE
T
IC
R
YN
LPV
T
IV
IF
NN
G-
-
G
I
Y
R
G
DGVD
L
SGAGAPSPTDLLHH
-----------
AR
Y
DK
L
M
D
A
F
R
GL
G
YN
V
TTTD
E
LRH
AL
TTGIQS
---
RK
P
TI
I
N
V
V
ID
PA
AGTESGHIT
KLN
P
K
Q
VA
G
fig|405955.13.peg.2632
Escherichia coli APEC O1 (13-563/564)
IIV
EA
L
KQN
NI
DT
I
Y
G
VV
G
IP
V
TD
M
A
R
H
A
QAE
-
G
-
I
R
Y
I
GF
RHEQ
S
A
GYA
A
A
A
S
G
FLT
Q
K
P
G
I
--
C
LTV
S
A
PG
F
L
N
G
L
T
A
LA
N
A
TV
N
GF
P
M
I
M
ISG
SSDRAI
VDLQ
Q
G
D
YE
E
L
D
QM
--------
NAAKPYA
K
AAF
R
V
NQP
Q
DL
G
IA
L
AR
A
IRV
S
V
S
-
GRPG
G
V
Y
L
DLP
A
N
V
LAATMEKD
---
EALTTIVKVENPS
P
ALLPCPKS
V
TS
A
ISL
L
AK
A
ER
P
L
I
IL
G
K
G
AAY
S
Q
S
DEQ
L
R
E
FIESAQI
P
FLPM
S
M
AK
G
IL
E
DT
HP
---
--
-
-
L
S
A
AAARSFA
L
A
NAD
V
V
ML
VG
A
R
L
NW
L
LAHGKKG
W
A
A
-
D
T
QF
I
Q
L
DI
E
P
Q
EI
DSNRPIA
V
P
V
VGD
IASS
M
QG
M
L
AE
L
KQNTFTT
PL
V
--
--
W
R
D
ILNIH
K
QQNAQKMHEKLST
D
----------------------------
T
-
-QPLNYFNA
L
SA
VRDV
LRENQDIY
L
V
NE
G
AN
T
L
D
N
A
RN
I
IDMYK
PR
RR
L
D
C
G
--------
TW
G
V
MG
I
G
MG
Y
AIGA
SV
T
S
G
S-P
VV
A
IE
GD
S
AFG
F
SGM
E
IE
T
IC
R
YN
LPV
T
IV
IF
NN
G-
-
G
I
Y
R
G
DGVD
L
SGAGAPSPTDLLHH
-----------
AR
Y
DK
L
M
D
A
F
R
GL
G
YN
V
TTTD
E
LRH
AL
TTGIQS
---
RK
P
TI
I
N
V
V
ID
PA
AGTESGHIT
KLN
P
K
Q
VA
G
fig|405955.9.peg.2157
Escherichia coli APEC O1 (13-563/564)
IIV
EA
L
KQN
NI
DT
I
Y
G
VV
G
IP
V
TD
M
A
R
H
A
QAE
-
G
-
I
R
Y
I
GF
RHEQ
S
A
GYA
A
A
A
S
G
FLT
Q
K
P
G
I
--
C
LTV
S
A
PG
F
L
N
G
L
T
A
LA
N
A
TV
N
GF
P
M
I
M
ISG
SSDRAI
VDLQ
Q
G
D
YE
E
L
D
QM
--------
NAAKPYA
K
AAF
R
V
NQP
Q
DL
G
IA
L
AR
A
IRV
S
V
S
-
GRPG
G
V
Y
L
DLP
A
N
V
LAATMEKD
---
EALTTIVKVENPS
P
ALLPCPKS
V
TS
A
ISL
L
AK
A
ER
P
L
I
IL
G
K
G
AAY
S
Q
S
DEQ
L
R
E
FIESAQI
P
FLPM
S
M
AK
G
IL
E
DT
HP
---
--
-
-
L
S
A
AAARSFA
L
A
NAD
V
V
ML
VG
A
R
L
NW
L
LAHGKKG
W
A
A
-
D
T
QF
I
Q
L
DI
E
P
Q
EI
DSNRPIA
V
P
V
VGD
IASS
M
QG
M
L
AE
L
KQNTFTT
PL
V
--
--
W
R
D
ILNIH
K
QQNAQKMHEKLST
D
----------------------------
T
-
-QPLNYFNA
L
SA
VRDV
LRENQDIY
L
V
NE
G
AN
T
L
D
N
A
RN
I
IDMYK
PR
RR
L
D
C
G
--------
TW
G
V
MG
I
G
MG
Y
AIGA
SV
T
S
G
S-P
VV
A
IE
GD
S
AFG
F
SGM
E
IE
T
IC
R
YN
LPV
T
IV
IF
NN
G-
-
G
I
Y
R
G
DGVD
L
SGAGAPSPTDLLHH
-----------
AR
Y
DK
L
M
D
A
F
R
GL
G
YN
V
TTTD
E
LRH
AL
TTGIQS
---
RK
P
TI
I
N
V
V
ID
PA
AGTESGHIT
KLN
P
K
Q
VA
G
fig|340197.3.peg.3909
Escherichia coli F11 (13-563/564)
IIV
EA
L
KQN
NI
DT
I
Y
G
VV
G
IP
V
TD
M
A
R
H
A
QAE
-
G
-
I
R
Y
I
GF
RHEQ
S
A
GYA
A
A
A
S
G
FLT
Q
K
P
G
I
--
C
LTV
S
A
PG
F
L
N
G
L
T
A
LA
N
A
TV
N
GF
P
M
I
M
ISG
SSDRAI
VDLQ
Q
G
D
YE
E
L
D
QM
--------
NAAKPYA
K
AAF
R
V
NQP
Q
DL
G
IA
L
AR
A
IRV
S
V
S
-
GRPG
G
V
Y
L
DLP
A
N
V
LAATMEKD
---
EALTTIVKVENPS
P
ALLPCPKS
V
TS
A
ISL
L
AK
A
ER
P
L
I
IL
G
K
G
AAY
S
Q
S
DEQ
L
R
E
FIESAQI
P
FLPM
S
M
AK
G
IL
E
DT
HP
---
--
-
-
L
S
A
AAARSFA
L
A
NAD
V
V
ML
VG
A
R
L
NW
L
LAHGKKG
W
A
A
-
D
T
QF
I
Q
L
DI
E
P
Q
EI
DSNRPIA
V
P
V
VGD
IASS
M
QG
M
L
AE
L
KQNTFTT
PL
V
--
--
W
R
D
ILNIH
K
QQNAQKMHEKLST
D
----------------------------
T
-
-QPLNYFNA
L
SA
VRDV
LRENQDIY
L
V
NE
G
AN
T
L
D
N
A
RN
I
IDMYK
PR
RR
L
D
C
G
--------
TW
G
V
MG
I
G
MG
Y
AIGA
SV
T
S
G
S-P
VV
A
IE
GD
S
AFG
F
SGM
E
IE
T
IC
R
YN
LPV
T
IV
IF
NN
G-
-
G
I
Y
R
G
DGVD
L
SGAGAPSPTDLLHH
-----------
AR
Y
DK
L
M
D
A
F
R
GL
G
YN
V
TTTD
E
LRH
AL
TTGIQS
---
RK
P
TI
I
N
V
V
ID
PA
AGTESGHIT
KLN
P
K
Q
VA
G
fig|340197.5.peg.4086
Escherichia coli F11 (13-563/564)
IIV
EA
L
KQN
NI
DT
I
Y
G
VV
G
IP
V
TD
M
A
R
H
A
QAE
-
G
-
I
R
Y
I
GF
RHEQ
S
A
GYA
A
A
A
S
G
FLT
Q
K
P
G
I
--
C
LTV
S
A
PG
F
L
N
G
L
T
A
LA
N
A
TV
N
GF
P
M
I
M
ISG
SSDRAI
VDLQ
Q
G
D
YE
E
L
D
QM
--------
NAAKPYA
K
AAF
R
V
NQP
Q
DL
G
IA
L
AR
A
IRV
S
V
S
-
GRPG
G
V
Y
L
DLP
A
N
V
LAATMEKD
---
EALTTIVKVENPS
P
ALLPCPKS
V
TS
A
ISL
L
AK
A
ER
P
L
I
IL
G
K
G
AAY
S
Q
S
DEQ
L
R
E
FIESAQI
P
FLPM
S
M
AK
G
IL
E
DT
HP
---
--
-
-
L
S
A
AAARSFA
L
A
NAD
V
V
ML
VG
A
R
L
NW
L
LAHGKKG
W
A
A
-
D
T
QF
I
Q
L
DI
E
P
Q
EI
DSNRPIA
V
P
V
VGD
IASS
M
QG
M
L
AE
L
KQNTFTT
PL
V
--
--
W
R
D
ILNIH
K
QQNAQKMHEKLST
D
----------------------------
T
-
-QPLNYFNA
L
SA
VRDV
LRENQDIY
L
V
NE
G
AN
T
L
D
N
A
RN
I
IDMYK
PR
RR
L
D
C
G
--------
TW
G
V
MG
I
G
MG
Y
AIGA
SV
T
S
G
S-P
VV
A
IE
GD
S
AFG
F
SGM
E
IE
T
IC
R
YN
LPV
T
IV
IF
NN
G-
-
G
I
Y
R
G
DGVD
L
SGAGAPSPTDLLHH
-----------
AR
Y
DK
L
M
D
A
F
R
GL
G
YN
V
TTTD
E
LRH
AL
TTGIQS
---
RK
P
TI
I
N
V
V
ID
PA
AGTESGHIT
KLN
P
K
Q
VA
G
fig|714962.3.peg.2739
Escherichia coli IHE3034 (13-563/564)
IIV
EA
L
KQN
NI
DT
I
Y
G
VV
G
IP
V
TD
M
A
R
H
A
QAE
-
G
-
I
R
Y
I
GF
RHEQ
S
A
GYA
A
A
A
S
G
FLT
Q
K
P
G
I
--
C
LTV
S
A
PG
F
L
N
G
L
T
A
LA
N
A
TV
N
GF
P
M
I
M
ISG
SSDRAI
VDLQ
Q
G
D
YE
E
L
D
QM
--------
NAAKPYA
K
AAF
R
V
NQP
Q
DL
G
IA
L
AR
A
IRV
S
V
S
-
GRPG
G
V
Y
L
DLP
A
N
V
LAATMEKD
---
EALTTIVKVENPS
P
ALLPCPKS
V
TS
A
ISL
L
AK
A
ER
P
L
I
IL
G
K
G
AAY
S
Q
S
DEQ
L
R
E
FIESAQI
P
FLPM
S
M
AK
G
IL
E
DT
HP
---
--
-
-
L
S
A
AAARSFA
L
A
NAD
V
V
ML
VG
A
R
L
NW
L
LAHGKKG
W
A
A
-
D
T
QF
I
Q
L
DI
E
P
Q
EI
DSNRPIA
V
P
V
VGD
IASS
M
QG
M
L
AE
L
KQNTFTT
PL
V
--
--
W
R
D
ILNIH
K
QQNAQKMHEKLST
D
----------------------------
T
-
-QPLNYFNA
L
SA
VRDV
LRENQDIY
L
V
NE
G
AN
T
L
D
N
A
RN
I
IDMYK
PR
RR
L
D
C
G
--------
TW
G
V
MG
I
G
MG
Y
AIGA
SV
T
S
G
S-P
VV
A
IE
GD
S
AFG
F
SGM
E
IE
T
IC
R
YN
LPV
T
IV
IF
NN
G-
-
G
I
Y
R
G
DGVD
L
SGAGAPSPTDLLHH
-----------
AR
Y
DK
L
M
D
A
F
R
GL
G
YN
V
TTTD
E
LRH
AL
TTGIQS
---
RK
P
TI
I
N
V
V
ID
PA
AGTESGHIT
KLN
P
K
Q
VA
G
fig|749550.3.peg.4989
Escherichia coli MS 200-1 (13-563/564)
IIV
EA
L
KQN
NI
DT
I
Y
G
VV
G
IP
V
TD
M
A
R
H
A
QAE
-
G
-
I
R
Y
I
GF
RHEQ
S
A
GYA
A
A
A
S
G
FLT
Q
K
P
G
I
--
C
LTV
S
A
PG
F
L
N
G
L
T
A
LA
N
A
TV
N
GF
P
M
I
M
ISG
SSDRAI
VDLQ
Q
G
D
YE
E
L
D
QM
--------
NAAKPYA
K
AAF
R
V
NQP
Q
DL
G
IA
L
AR
A
IRV
S
V
S
-
GRPG
G
V
Y
L
DLP
A
N
V
LAATMEKD
---
EALTTIVKVENPS
P
ALLPCPKS
V
TS
A
ISL
L
AK
A
ER
P
L
I
IL
G
K
G
AAY
S
Q
S
DEQ
L
R
E
FIESAQI
P
FLPM
S
M
AK
G
IL
E
DT
HP
---
--
-
-
L
S
A
AAARSFA
L
A
NAD
V
V
ML
VG
A
R
L
NW
L
LAHGKKG
W
A
A
-
D
T
QF
I
Q
L
DI
E
P
Q
EI
DSNRPIA
V
P
V
VGD
IASS
M
QG
M
L
AE
L
KQNTFTT
PL
V
--
--
W
R
D
ILNIH
K
QQNAQKMHEKLST
D
----------------------------
T
-
-QPLNYFNA
L
SA
VRDV
LRENQDIY
L
V
NE
G
AN
T
L
D
N
A
RN
I
IDMYK
PR
RR
L
D
C
G
--------
TW
G
V
MG
I
G
MG
Y
AIGA
SV
T
S
G
S-P
VV
A
IE
GD
S
AFG
F
SGM
E
IE
T
IC
R
YN
LPV
T
IV
IF
NN
G-
-
G
I
Y
R
G
DGVD
L
SGAGAPSPTDLLHH
-----------
AR
Y
DK
L
M
D
A
F
R
GL
G
YN
V
TTTD
E
LRH
AL
TTGIQS
---
RK
P
TI
I
N
V
V
ID
PA
AGTESGHIT
KLN
P
K
Q
VA
G
fig|585035.6.peg.2537
Escherichia coli S88 (13-563/564)
IIV
EA
L
KQN
NI
DT
I
Y
G
VV
G
IP
V
TD
M
A
R
H
A
QAE
-
G
-
I
R
Y
I
GF
RHEQ
S
A
GYA
A
A
A
S
G
FLT
Q
K
P
G
I
--
C
LTV
S
A
PG
F
L
N
G
L
T
A
LA
N
A
TV
N
GF
P
M
I
M
ISG
SSDRAI
VDLQ
Q
G
D
YE
E
L
D
QM
--------
NAAKPYA
K
AAF
R
V
NQP
Q
DL
G
IA
L
AR
A
IRV
S
V
S
-
GRPG
G
V
Y
L
DLP
A
N
V
LAATMEKD
---
EALTTIVKVENPS
P
ALLPCPKS
V
TS
A
ISL
L
AK
A
ER
P
L
I
IL
G
K
G
AAY
S
Q
S
DEQ
L
R
E
FIESAQI
P
FLPM
S
M
AK
G
IL
E
DT
HP
---
--
-
-
L
S
A
AAARSFA
L
A
NAD
V
V
ML
VG
A
R
L
NW
L
LAHGKKG
W
A
A
-
D
T
QF
I
Q
L
DI
E
P
Q
EI
DSNRPIA
V
P
V
VGD
IASS
M
QG
M
L
AE
L
KQNTFTT
PL
V
--
--
W
R
D
ILNIH
K
QQNAQKMHEKLST
D
----------------------------
T
-
-QPLNYFNA
L
SA
VRDV
LRENQDIY
L
V
NE
G
AN
T
L
D
N
A
RN
I
IDMYK
PR
RR
L
D
C
G
--------
TW
G
V
MG
I
G
MG
Y
AIGA
SV
T
S
G
S-P
VV
A
IE
GD
S
AFG
F
SGM
E
IE
T
IC
R
YN
LPV
T
IV
IF
NN
G-
-
G
I
Y
R
G
DGVD
L
SGAGAPSPTDLLHH
-----------
AR
Y
DK
L
M
D
A
F
R
GL
G
YN
V
TTTD
E
LRH
AL
TTGIQS
---
RK
P
TI
I
N
V
V
ID
PA
AGTESGHIT
KLN
P
K
Q
VA
G
fig|869729.3.peg.1014
Escherichia coli UM146 (13-563/564)
IIV
EA
L
KQN
NI
DT
I
Y
G
VV
G
IP
V
TD
M
A
R
H
A
QAE
-
G
-
I
R
Y
I
GF
RHEQ
S
A
GYA
A
A
A
S
G
FLT
Q
K
P
G
I
--
C
LTV
S
A
PG
F
L
N
G
L
T
A
LA
N
A
TV
N
GF
P
M
I
M
ISG
SSDRAI
VDLQ
Q
G
D
YE
E
L
D
QM
--------
NAAKPYA
K
AAF
R
V
NQP
Q
DL
G
IA
L
AR
A
IRV
S
V
S
-
GRPG
G
V
Y
L
DLP
A
N
V
LAATMEKD
---
EALTTIVKVENPS
P
ALLPCPKS
V
TS
A
ISL
L
AK
A
ER
P
L
I
IL
G
K
G
AAY
S
Q
S
DEQ
L
R
E
FIESAQI
P
FLPM
S
M
AK
G
IL
E
DT
HP
---
--
-
-
L
S
A
AAARSFA
L
A
NAD
V
V
ML
VG
A
R
L
NW
L
LAHGKKG
W
A
A
-
D
T
QF
I
Q
L
DI
E
P
Q
EI
DSNRPIA
V
P
V
VGD
IASS
M
QG
M
L
AE
L
KQNTFTT
PL
V
--
--
W
R
D
ILNIH
K
QQNAQKMHEKLST
D
----------------------------
T
-
-QPLNYFNA
L
SA
VRDV
LRENQDIY
L
V
NE
G
AN
T
L
D
N
A
RN
I
IDMYK
PR
RR
L
D
C
G
--------
TW
G
V
MG
I
G
MG
Y
AIGA
SV
T
S
G
S-P
VV
A
IE
GD
S
AFG
F
SGM
E
IE
T
IC
R
YN
LPV
T
IV
IF
NN
G-
-
G
I
Y
R
G
DGVD
L
SGAGAPSPTDLLHH
-----------
AR
Y
DK
L
M
D
A
F
R
GL
G
YN
V
TTTD
E
LRH
AL
TTGIQS
---
RK
P
TI
I
N
V
V
ID
PA
AGTESGHIT
KLN
P
K
Q
VA
G
fig|364106.7.peg.2718
Escherichia coli UTI89 (13-563/564)
IIV
EA
L
KQN
NI
DT
I
Y
G
VV
G
IP
V
TD
M
A
R
H
A
QAE
-
G
-
I
R
Y
I
GF
RHEQ
S
A
GYA
A
A
A
S
G
FLT
Q
K
P
G
I
--
C
LTV
S
A
PG
F
L
N
G
L
T
A
LA
N
A
TV
N
GF
P
M
I
M
ISG
SSDRAI
VDLQ
Q
G
D
YE
E
L
D
QM
--------
NAAKPYA
K
AAF
R
V
NQP
Q
DL
G
IA
L
AR
A
IRV
S
V
S
-
GRPG
G
V
Y
L
DLP
A
N
V
LAATMEKD
---
EALTTIVKVENPS
P
ALLPCPKS
V
TS
A
ISL
L
AK
A
ER
P
L
I
IL
G
K
G
AAY
S
Q
S
DEQ
L
R
E
FIESAQI
P
FLPM
S
M
AK
G
IL
E
DT
HP
---
--
-
-
L
S
A
AAARSFA
L
A
NAD
V
V
ML
VG
A
R
L
NW
L
LAHGKKG
W
A
A
-
D
T
QF
I
Q
L
DI
E
P
Q
EI
DSNRPIA
V
P
V
VGD
IASS
M
QG
M
L
AE
L
KQNTFTT
PL
V
--
--
W
R
D
ILNIH
K
QQNAQKMHEKLST
D
----------------------------
T
-
-QPLNYFNA
L
SA
VRDV
LRENQDIY
L
V
NE
G
AN
T
L
D
N
A
RN
I
IDMYK
PR
RR
L
D
C
G
--------
TW
G
V
MG
I
G
MG
Y
AIGA
SV
T
S
G
S-P
VV
A
IE
GD
S
AFG
F
SGM
E
IE
T
IC
R
YN
LPV
T
IV
IF
NN
G-
-
G
I
Y
R
G
DGVD
L
SGAGAPSPTDLLHH
-----------
AR
Y
DK
L
M
D
A
F
R
GL
G
YN
V
TTTD
E
LRH
AL
TTGIQS
---
RK
P
TI
I
N
V
V
ID
PA
AGTESGHIT
KLN
P
K
Q
VA
G
fig|364106.8.peg.2718
Escherichia coli UTI89 (13-563/564)
IIV
EA
L
KQN
NI
DT
I
Y
G
VV
G
IP
V
TD
M
A
R
H
A
QAE
-
G
-
I
R
Y
I
GF
RHEQ
S
A
GYA
A
A
A
S
G
FLT
Q
K
P
G
I
--
C
LTV
S
A
PG
F
L
N
G
L
T
A
LA
N
A
TV
N
GF
P
M
I
M
ISG
SSDRAI
VDLQ
Q
G
D
YE
E
L
D
QM
--------
NAAKPYA
K
AAF
R
V
NQP
Q
DL
G
IA
L
AR
A
IRV
S
V
S
-
GRPG
G
V
Y
L
DLP
A
N
V
LAATMEKD
---
EALTTIVKVENPS
P
ALLPCPKS
V
TS
A
ISL
L
AK
A
ER
P
L
I
IL
G
K
G
AAY
S
Q
S
DEQ
L
R
E
FIESAQI
P
FLPM
S
M
AK
G
IL
E
DT
HP
---
--
-
-
L
S
A
AAARSFA
L
A
NAD
V
V
ML
VG
A
R
L
NW
L
LAHGKKG
W
A
A
-
D
T
QF
I
Q
L
DI
E
P
Q
EI
DSNRPIA
V
P
V
VGD
IASS
M
QG
M
L
AE
L
KQNTFTT
PL
V
--
--
W
R
D
ILNIH
K
QQNAQKMHEKLST
D
----------------------------
T
-
-QPLNYFNA
L
SA
VRDV
LRENQDIY
L
V
NE
G
AN
T
L
D
N
A
RN
I
IDMYK
PR
RR
L
D
C
G
--------
TW
G
V
MG
I
G
MG
Y
AIGA
SV
T
S
G
S-P
VV
A
IE
GD
S
AFG
F
SGM
E
IE
T
IC
R
YN
LPV
T
IV
IF
NN
G-
-
G
I
Y
R
G
DGVD
L
SGAGAPSPTDLLHH
-----------
AR
Y
DK
L
M
D
A
F
R
GL
G
YN
V
TTTD
E
LRH
AL
TTGIQS
---
RK
P
TI
I
N
V
V
ID
PA
AGTESGHIT
KLN
P
K
Q
VA
G
fig|656437.3.peg.2702
Escherichia coli TA143 (13-563/564)
IIV
EA
L
KQN
NI
DT
I
Y
G
VV
G
IP
V
TD
M
A
R
H
A
QAE
-
G
-
I
R
Y
I
GF
RHEQ
S
A
GYA
A
A
A
S
G
FLT
Q
K
P
G
I
--
C
LTV
S
A
PG
F
L
N
G
L
T
A
LA
N
A
TV
N
GF
P
M
I
M
ISG
SSDRAI
VDLQ
Q
G
D
YE
E
L
D
QM
--------
NAAKPYA
K
AAF
R
V
NQP
Q
DL
G
IA
L
AR
A
IRV
S
V
S
-
GRPG
G
V
Y
L
DLP
A
N
V
LAATMEKD
---
EALTTIVKVENPS
P
ALLPCPKS
V
TS
A
ISL
L
AK
A
ER
P
L
I
IL
G
K
G
AAY
S
Q
A
DEQ
L
R
E
FIESAQI
P
FLPM
S
M
AK
G
IL
E
DT
HP
---
--
-
-
L
S
A
AAARSFA
L
A
NAD
V
V
ML
VG
A
R
L
NW
L
LAHGKKG
W
A
A
-
D
T
QF
I
Q
LE
I
E
P
Q
EI
DSNRPIA
V
P
V
VGD
IASS
M
QG
M
L
AE
L
KQNTFTT
PL
V
--
--
W
R
D
ILNIH
K
QQNAQKMHEKLST
D
----------------------------
T
-
-QPLNYFNA
L
SA
VRDV
LRENQDIY
L
V
NE
G
AN
T
L
D
N
A
RN
I
IDMYK
PR
RR
L
D
C
G
--------
TW
G
V
MG
I
G
MG
Y
AIGA
SV
T
S
G
S-P
VV
A
IE
GD
S
AFG
F
SGM
E
IE
T
IC
R
YN
LPV
T
IV
IF
NN
G-
-
G
I
Y
R
G
DGVD
L
SGAGAPSPTDLLHH
-----------
AR
Y
DK
L
M
D
A
F
R
GV
G
YN
V
TTTD
E
LRH
AL
TTGIQS
---
RK
P
TI
I
N
V
V
ID
PA
AGTESGHIT
KLN
P
K
Q
VA
G
fig|656419.3.peg.3139
Escherichia coli M718 (13-563/564)
IIV
EA
L
KQN
NI
DT
I
Y
G
VV
G
IP
V
TD
M
A
R
H
A
QAE
-
G
-
I
R
Y
I
GF
RHEQ
S
A
GYA
A
A
A
S
G
FLT
Q
K
P
G
I
--
C
LTV
S
A
PG
F
L
N
G
L
T
A
LA
N
A
TV
N
GF
P
M
I
M
ISG
SSDRAI
VDLQ
Q
G
D
YE
E
L
D
QM
--------
NAAKPYA
K
AAF
R
V
NQP
Q
DL
G
IA
L
AR
A
IRV
S
V
S
-
GRPG
G
V
Y
L
DLP
A
N
V
LAATMEKD
---
EALTTIVKVENPS
P
ALLPCPKS
V
TS
A
ISL
L
AK
A
ER
P
L
I
IL
G
K
G
AAY
S
Q
A
DEQ
L
R
E
FIESAQI
P
FLPM
S
M
AK
G
IL
E
DT
HP
---
--
-
-
L
S
A
AAARSFA
L
A
NAD
V
V
ML
VG
A
R
L
NW
L
LAHGKKG
W
A
A
-
D
T
QF
I
Q
L
DI
E
P
Q
EI
DSNRPIA
V
P
V
VGD
IASS
M
QG
M
L
AE
L
KQNTFTT
PL
V
--
--
W
R
D
ILNIH
K
QQNAQKMHEKLST
D
----------------------------
T
-
-QPLNYFNA
L
SA
VRDV
LRENQYIY
L
V
NE
G
AN
T
L
D
N
A
RN
I
IDMYK
PR
RR
L
D
C
G
--------
TW
G
V
MG
I
G
MG
Y
AIGA
SV
T
S
G
S-P
VV
A
IE
GD
S
AFG
F
SGM
E
IE
T
IC
R
YN
LPV
T
IV
IF
NN
G-
-
G
I
Y
R
G
DGVD
L
SGAGAPSPTDLLHH
-----------
AR
Y
DK
L
M
D
A
F
R
GV
G
YN
V
TTTD
E
LRH
AL
TTGIQS
---
RK
P
TI
I
N
V
V
ID
PA
AGTESGHIT
KLN
P
K
Q
VA
G
fig|585397.7.peg.305
Escherichia coli ED1a (20-616/634)
K
G
I
FA
I
F
G
H-
-
GN
V
VG
L
G
Q
A
L
EED
C
G
Q
L
S
VH
QG
R
N
EQ
G
M
AHI
A
T
G
F
A
RQM
R
R
H
Q
I
YA
C
TSS
V
GPG
A
A
N
M
IT
A
A
A
T
A
TA
N
RI
PL
L
L
L
P
G
DVYASR
QP
--
D
P
V
L
Q
Q
V
E
QE
HDLTLSTN
DAFRAVS
R
YWD
R
I
TRP
E
Q
L
M
SA
C
IS
A
MRV
L
T
DPADT
G
A
V
T
L
C
LP
Q
DV
QGEAWDYP
---
DYFFARRVYRLER
-
-HAPTEPM
L
NE
A
VAL
I
RR
H
QR
P
L
I
VC
G
G
G
VKY
S
Q
A
EEA
L
L
R
FAERCHL
P
IAET
Q
A
G
K
G
AL
S
SA
HP
LNV
G
G
I
G
E
T
G
SLAANLL
A
Q
E
AD
L
I
IG
VG
T
R
Y
TD
F
TTSSKWI
F
Q
-
-
N
P
DV
R
YLN
I
N
V
S
RF
DVFKLDG
V
Q
M
Q
GD
ARVA
L
TQ
L
S
ER
L
AQEHYAS
--
-
--
-Q
W
G
E
TIHRV
R
SQYMAEVERVYAV
E
YSGEGFKPEIEDHMDTQKVFEEFNEITR
S
W
LTQTRVLGV
L
NR
----
MLPENALV
V
A
AA
G
S-
--
-
--
--
-
LPGDL
Q
R
VW
Q
S
R
G
ENDYHVEY
GY
S
C
MG
Y
E
V
N
A
A
L
GA
KL
A
Q
P
ERE
V
YS
FV
GDG
SFM
M
LHS
E
LV
T
SV
Q
MG
KK
I
T
VI
LL
D
N
MT
N
G
C
I
N
N
LQME
H
GMDSYFTEFRFHQQ
ESGRQEGGFIP
VD
F
AR
I
A
E
G
Y
G
CK
S
YR
V
TTIE
Q
LHE
AL
EDARKQ
---
AV
S
TL
I
D
I
K
V
L
PK
TMVH
----
K
YLS
W
W
R
VG
GA
Q
V
S
RSER
fig|585397.9.peg.306
Escherichia coli ED1a (20-616/634)
K
G
I
FA
I
F
G
H-
-
GN
V
VG
L
G
Q
A
L
EED
C
G
Q
L
S
VH
QG
R
N
EQ
G
M
AHI
A
T
G
F
A
RQM
R
R
H
Q
I
YA
C
TSS
V
GPG
A
A
N
M
IT
A
A
A
T
A
TA
N
RI
PL
L
L
L
P
G
DVYASR
QP
--
D
P
V
L
Q
Q
V
E
QE
HDLTLSTN
DAFRAVS
R
YWD
R
I
TRP
E
Q
L
M
SA
C
IS
A
MRV
L
T
DPADT
G
A
V
T
L
C
LP
Q
DV
QGEAWDYP
---
DYFFARRVYRLER
-
-HAPTEPM
L
NE
A
VAL
I
RR
H
QR
P
L
I
VC
G
G
G
VKY
S
Q
A
EEA
L
L
R
FAERCHL
P
IAET
Q
A
G
K
G
AL
S
SA
HP
LNV
G
G
I
G
E
T
G
SLAANLL
A
Q
E
AD
L
I
IG
VG
T
R
Y
TD
F
TTSSKWI
F
Q
-
-
N
P
DV
R
YLN
I
N
V
S
RF
DVFKLDG
V
Q
M
Q
GD
ARVA
L
TQ
L
S
ER
L
AQEHYAS
--
-
--
-Q
W
G
E
TIHRV
R
SQYMAEVERVYAV
E
YSGEGFKPEIEDHMDTQKVFEEFNEITR
S
W
LTQTRVLGV
L
NR
----
MLPENALV
V
A
AA
G
S-
--
-
--
--
-
LPGDL
Q
R
VW
Q
S
R
G
ENDYHVEY
GY
S
C
MG
Y
E
V
N
A
A
L
GA
KL
A
Q
P
ERE
V
YS
FV
GDG
SFM
M
LHS
E
LV
T
SV
Q
MG
KK
I
T
VI
LL
D
N
MT
N
G
C
I
N
N
LQME
H
GMDSYFTEFRFHQQ
ESGRQEGGFIP
VD
F
AR
I
A
E
G
Y
G
CK
S
YR
V
TTIE
Q
LHE
AL
EDARKQ
---
AV
S
TL
I
D
I
K
V
L
PK
TMVH
----
K
YLS
W
W
R
VG
GA
Q
V
S
RSER
Consen1
Primary consensus
iiv
L
gv
v
G
G
v
v
d
l
-
g
i
hi
RHEq
A
A
g
a
gk
gv
--
c
sgPG
tn
itgla
a
d
Pli
isg
ig
--
d
fqE
d
--------
k
lV
edlp
l
A
a
s
-
gRpG
v
vdlP
dv
---
-
i
a
l
a
p
l
G
G
a
a
l
E
P
l
glg
e
hp
gm
gm
g
l
naD
l
vG
rf
r
f
p
-
na
ihiDIdp
ei
vaivgD
l
ll
l
pl
--
w
q
r
d
----------------------------
-
l
----
t
dvG
qm
aA
-
pr
l
s
--------
G
Mg
glp
AiGa
a
p
Vvc
GDg
m
e
t
q
Lpv
iv
nN
lG
v
-
l
-----------
f
la
a
g
g
v
e
aL
---
p
ihV
id
--------
e
P
q
Ga
n
EMWLSKTERT
Consen2
Secondary consensus
mva
ni
i
r
a
t
v
e
a
g
qe
ai
v
ca
lh
naif
c
n
l
a
vdlq
g
ye
h
h
r
q
ig
m
s
l
n
-
s
vi
ni
yvw
p
l
i
s
i
s
c
v
s
ake
p
r
--
-
l
a
ec
l
ql
l
at
t
lq
r
s
p
qa
m
mi
v
fr
ei
-
e
a
vrdv
l
ne
t
i
ke
i
c
a
amg
v
t
g
la
s
f
d
s
dl
vi
d
-
y
g
m
y
im
g
r
t
k
vrn
l
va
agtesghit
v
g
m
Consensus 1
(when a gap)
Conservative difference
Consensus 2
(when a gap)
Nonconservative diff.
Other character