fig|1040638.4.peg.5634
Escherichia coli O104:H4 str. LB226692
MSKN
YH
IA
V
L
PGDGIG
P
EV
M
T
QA
LKVLDA
V
R
N
R
F
---
AMR
I
T
TSHYDV
G
GAA
-
IDN
HGQ
P
--
LP
PA
T
V
E
GCE
Q
A
DA
VL
FG
S
VG
GPK
W
EHLP
PD
QQ
P
ER
G
A
L
----
L
P
LR
K
H
F
K
L
F
S
NLRP
AK
LYQG
L
EAF
CPL
R
A
D
I
A
A
NGF
D
ILC
VRE
L
T
G
GIY
F
GQPK
GR
EG
SG
-
Q
Y
EK
AF
DTE
V
Y
H
R
F
E
I
-----------------------
E
RI
A
R
I
AFE
S
A
RK
R
-
R
HK
VTS
ID
K
A
N
V
L
QS
S
I-L
W
R
E
I
V
NE
IA
T
EY
--------------------
P
DV
ELAHMY
ID
NATM
Q
L
I
KD
P
S
QFDV
L
L
CSNLFGDILSD
EC
A
M
I
TG
S
M
G
ML
PSA
S
LN
-
E
QG
F
-
G
L
Y
EP
A
G
GSAPDIAGKNIANPIA
Q
ILS
L
A
LL
LR
Y
S
L
DA
D
D
-
---
AA
CA
I
ER
AI
N
R
A
L
EE
G
IR
T
G
D
LA
R
---
GAA
AVS
T
D
E
M
GD
I
I
A
R
YVAEGV
fig|6666666.5357.peg.1556
Escherichia coli TY-2482
MSKN
YH
IA
V
L
PGDGIG
P
EV
M
T
QA
LKVLDA
V
R
N
R
F
---
AMR
I
T
TSHYDV
G
GAA
-
IDN
HGQ
P
--
LP
PA
T
V
E
GCE
Q
A
DA
VL
FG
S
VG
GPK
W
EHLP
PD
QQ
P
ER
G
A
L
----
L
P
LR
K
H
F
K
L
F
S
NLRP
AK
LYQG
L
EAF
CPL
R
A
D
I
A
A
NGF
D
ILC
VRE
L
T
G
GIY
F
GQPK
GR
EG
SG
-
Q
Y
EK
AF
DTE
V
Y
H
R
F
E
I
-----------------------
E
RI
A
R
I
AFE
S
A
RK
R
-
R
HK
VTS
ID
K
A
N
V
L
QS
S
I-L
W
R
E
I
V
NE
IA
T
EY
--------------------
P
DV
ELAHMY
ID
NATM
Q
L
I
KD
P
S
QFDV
L
L
CSNLFGDILSD
EC
A
M
I
TG
S
M
G
ML
PSA
S
LN
-
E
QG
F
-
G
L
Y
EP
A
G
GSAPDIAGKNIANPIA
Q
ILS
L
A
LL
LR
Y
S
L
DA
D
D
-
---
AA
CA
I
ER
AI
N
R
A
L
EE
G
IR
T
G
D
LA
R
---
GAA
AVS
T
D
E
M
GD
I
I
A
R
YVAEGV
fig|358709.5.peg.4143
Escherichia coli 101-1
MSKN
YH
IA
V
L
PGDGIG
P
EV
M
T
QA
LKVLDA
V
R
N
R
F
---
AMR
I
T
TSHYDV
G
GAA
-
IDN
HGQ
P
--
LP
PA
T
V
E
GCE
Q
A
DA
VL
FG
S
VG
GPK
W
EHLP
PD
QQ
P
ER
G
A
L
----
L
P
LR
K
H
F
K
L
F
S
NLRP
AK
LYQG
L
EAF
CPL
R
A
D
I
A
A
NGF
D
ILC
VRE
L
T
G
GIY
F
GQPK
GR
EG
SG
-
Q
Y
EK
AF
DTE
V
Y
H
R
F
E
I
-----------------------
E
RI
A
R
I
AFE
S
A
RK
R
-
R
HK
VTS
ID
K
A
N
V
L
QS
S
I-L
W
R
E
I
V
NE
IA
T
EY
--------------------
P
DV
ELAHMY
ID
NATM
Q
L
I
KD
P
S
QFDV
L
L
CSNLFGDILSD
EC
A
M
I
TG
S
M
G
ML
PSA
S
LN
-
E
QG
F
-
G
L
Y
EP
A
G
GSAPDIAGKNIANPIA
Q
ILS
L
A
LL
LR
Y
S
L
DA
D
D
-
---
AA
CA
I
ER
AI
N
R
A
L
EE
G
IR
T
G
D
LA
R
---
GAA
AVS
T
D
E
M
GD
I
I
A
R
YVAEGV
fig|670888.3.peg.654
Escherichia coli 1827-70
MSKN
YH
IA
V
L
PGDGIG
P
EV
M
T
QA
LKVLDA
V
R
N
R
F
---
AMR
I
T
TSHYDV
G
GAA
-
IDN
HGQ
P
--
LP
PA
T
V
E
GCE
Q
A
DA
VL
FG
S
VG
GPK
W
EHLP
PD
QQ
P
ER
G
A
L
----
L
P
LR
K
H
F
K
L
F
S
NLRP
AK
LYQG
L
EAF
CPL
R
A
D
I
A
A
NGF
D
ILC
VRE
L
T
G
GIY
F
GQPK
GR
EG
SG
-
Q
Y
EK
AF
DTE
V
Y
H
R
F
E
I
-----------------------
E
RI
A
R
I
AFE
S
A
RK
R
-
R
HK
VTS
ID
K
A
N
V
L
QS
S
I-L
W
R
E
I
V
NE
IA
T
EY
--------------------
P
DV
ELAHMY
ID
NATM
Q
L
I
KD
P
S
QFDV
L
L
CSNLFGDILSD
EC
A
M
I
TG
S
M
G
ML
PSA
S
LN
-
E
QG
F
-
G
L
Y
EP
A
G
GSAPDIAGKNIANPIA
Q
ILS
L
A
LL
LR
Y
S
L
DA
D
D
-
---
AA
CA
I
ER
AI
N
R
A
L
EE
G
IR
T
G
D
LA
R
---
GAA
AVS
T
D
E
M
GD
I
I
A
R
YVAEGV
fig|344610.3.peg.4318
Escherichia coli 53638
MSKN
YH
IA
V
L
PGDGIG
P
EV
M
T
QA
LKVLDA
V
R
N
R
F
---
AMR
I
T
TSHYDV
G
GAA
-
IDN
HGQ
P
--
LP
PA
T
V
E
GCE
Q
A
DA
VL
FG
S
VG
GPK
W
EHLP
PD
QQ
P
ER
G
A
L
----
L
P
LR
K
H
F
K
L
F
S
NLRP
AK
LYQG
L
EAF
CPL
R
A
D
I
A
A
NGF
D
ILC
VRE
L
T
G
GIY
F
GQPK
GR
EG
SG
-
Q
Y
EK
AF
DTE
V
Y
H
R
F
E
I
-----------------------
E
RI
A
R
I
AFE
S
A
RK
R
-
R
HK
VTS
ID
K
A
N
V
L
QS
S
I-L
W
R
E
I
V
NE
IA
T
EY
--------------------
P
DV
ELAHMY
ID
NATM
Q
L
I
KD
P
S
QFDV
L
L
CSNLFGDILSD
EC
A
M
I
TG
S
M
G
ML
PSA
S
LN
-
E
QG
F
-
G
L
Y
EP
A
G
GSAPDIAGKNIANPIA
Q
ILS
L
A
LL
LR
Y
S
L
DA
D
D
-
---
AA
CA
I
ER
AI
N
R
A
L
EE
G
IR
T
G
D
LA
R
---
GAA
AVS
T
D
E
M
GD
I
I
A
R
YVAEGV
fig|344610.7.peg.1666
Escherichia coli 53638
MSKN
YH
IA
V
L
PGDGIG
P
EV
M
T
QA
LKVLDA
V
R
N
R
F
---
AMR
I
T
TSHYDV
G
GAA
-
IDN
HGQ
P
--
LP
PA
T
V
E
GCE
Q
A
DA
VL
FG
S
VG
GPK
W
EHLP
PD
QQ
P
ER
G
A
L
----
L
P
LR
K
H
F
K
L
F
S
NLRP
AK
LYQG
L
EAF
CPL
R
A
D
I
A
A
NGF
D
ILC
VRE
L
T
G
GIY
F
GQPK
GR
EG
SG
-
Q
Y
EK
AF
DTE
V
Y
H
R
F
E
I
-----------------------
E
RI
A
R
I
AFE
S
A
RK
R
-
R
HK
VTS
ID
K
A
N
V
L
QS
S
I-L
W
R
E
I
V
NE
IA
T
EY
--------------------
P
DV
ELAHMY
ID
NATM
Q
L
I
KD
P
S
QFDV
L
L
CSNLFGDILSD
EC
A
M
I
TG
S
M
G
ML
PSA
S
LN
-
E
QG
F
-
G
L
Y
EP
A
G
GSAPDIAGKNIANPIA
Q
ILS
L
A
LL
LR
Y
S
L
DA
D
D
-
---
AA
CA
I
ER
AI
N
R
A
L
EE
G
IR
T
G
D
LA
R
---
GAA
AVS
T
D
E
M
GD
I
I
A
R
YVAEGV
fig|585055.6.peg.75
Escherichia coli 55989
MSKN
YH
IA
V
L
PGDGIG
P
EV
M
T
QA
LKVLDA
V
R
N
R
F
---
AMR
I
T
TSHYDV
G
GAA
-
IDN
HGQ
P
--
LP
PA
T
V
E
GCE
Q
A
DA
VL
FG
S
VG
GPK
W
EHLP
PD
QQ
P
ER
G
A
L
----
L
P
LR
K
H
F
K
L
F
S
NLRP
AK
LYQG
L
EAF
CPL
R
A
D
I
A
A
NGF
D
ILC
VRE
L
T
G
GIY
F
GQPK
GR
EG
SG
-
Q
Y
EK
AF
DTE
V
Y
H
R
F
E
I
-----------------------
E
RI
A
R
I
AFE
S
A
RK
R
-
R
HK
VTS
ID
K
A
N
V
L
QS
S
I-L
W
R
E
I
V
NE
IA
T
EY
--------------------
P
DV
ELAHMY
ID
NATM
Q
L
I
KD
P
S
QFDV
L
L
CSNLFGDILSD
EC
A
M
I
TG
S
M
G
ML
PSA
S
LN
-
E
QG
F
-
G
L
Y
EP
A
G
GSAPDIAGKNIANPIA
Q
ILS
L
A
LL
LR
Y
S
L
DA
D
D
-
---
AA
CA
I
ER
AI
N
R
A
L
EE
G
IR
T
G
D
LA
R
---
GAA
AVS
T
D
E
M
GD
I
I
A
R
YVAEGV
fig|585055.8.peg.75
Escherichia coli 55989
MSKN
YH
IA
V
L
PGDGIG
P
EV
M
T
QA
LKVLDA
V
R
N
R
F
---
AMR
I
T
TSHYDV
G
GAA
-
IDN
HGQ
P
--
LP
PA
T
V
E
GCE
Q
A
DA
VL
FG
S
VG
GPK
W
EHLP
PD
QQ
P
ER
G
A
L
----
L
P
LR
K
H
F
K
L
F
S
NLRP
AK
LYQG
L
EAF
CPL
R
A
D
I
A
A
NGF
D
ILC
VRE
L
T
G
GIY
F
GQPK
GR
EG
SG
-
Q
Y
EK
AF
DTE
V
Y
H
R
F
E
I
-----------------------
E
RI
A
R
I
AFE
S
A
RK
R
-
R
HK
VTS
ID
K
A
N
V
L
QS
S
I-L
W
R
E
I
V
NE
IA
T
EY
--------------------
P
DV
ELAHMY
ID
NATM
Q
L
I
KD
P
S
QFDV
L
L
CSNLFGDILSD
EC
A
M
I
TG
S
M
G
ML
PSA
S
LN
-
E
QG
F
-
G
L
Y
EP
A
G
GSAPDIAGKNIANPIA
Q
ILS
L
A
LL
LR
Y
S
L
DA
D
D
-
---
AA
CA
I
ER
AI
N
R
A
L
EE
G
IR
T
G
D
LA
R
---
GAA
AVS
T
D
E
M
GD
I
I
A
R
YVAEGV
fig|481805.3.peg.3848
Escherichia coli ATCC 8739
MSKN
YH
IA
V
L
PGDGIG
P
EV
M
T
QA
LKVLDA
V
R
N
R
F
---
AMR
I
T
TSHYDV
G
GAA
-
IDN
HGQ
P
--
LP
PA
T
V
E
GCE
Q
A
DA
VL
FG
S
VG
GPK
W
EHLP
PD
QQ
P
ER
G
A
L
----
L
P
LR
K
H
F
K
L
F
S
NLRP
AK
LYQG
L
EAF
CPL
R
A
D
I
A
A
NGF
D
ILC
VRE
L
T
G
GIY
F
GQPK
GR
EG
SG
-
Q
Y
EK
AF
DTE
V
Y
H
R
F
E
I
-----------------------
E
RI
A
R
I
AFE
S
A
RK
R
-
R
HK
VTS
ID
K
A
N
V
L
QS
S
I-L
W
R
E
I
V
NE
IA
T
EY
--------------------
P
DV
ELAHMY
ID
NATM
Q
L
I
KD
P
S
QFDV
L
L
CSNLFGDILSD
EC
A
M
I
TG
S
M
G
ML
PSA
S
LN
-
E
QG
F
-
G
L
Y
EP
A
G
GSAPDIAGKNIANPIA
Q
ILS
L
A
LL
LR
Y
S
L
DA
D
D
-
---
AA
CA
I
ER
AI
N
R
A
L
EE
G
IR
T
G
D
LA
R
---
GAA
AVS
T
D
E
M
GD
I
I
A
R
YVAEGV
fig|481805.6.peg.3827
Escherichia coli ATCC 8739
MSKN
YH
IA
V
L
PGDGIG
P
EV
M
T
QA
LKVLDA
V
R
N
R
F
---
AMR
I
T
TSHYDV
G
GAA
-
IDN
HGQ
P
--
LP
PA
T
V
E
GCE
Q
A
DA
VL
FG
S
VG
GPK
W
EHLP
PD
QQ
P
ER
G
A
L
----
L
P
LR
K
H
F
K
L
F
S
NLRP
AK
LYQG
L
EAF
CPL
R
A
D
I
A
A
NGF
D
ILC
VRE
L
T
G
GIY
F
GQPK
GR
EG
SG
-
Q
Y
EK
AF
DTE
V
Y
H
R
F
E
I
-----------------------
E
RI
A
R
I
AFE
S
A
RK
R
-
R
HK
VTS
ID
K
A
N
V
L
QS
S
I-L
W
R
E
I
V
NE
IA
T
EY
--------------------
P
DV
ELAHMY
ID
NATM
Q
L
I
KD
P
S
QFDV
L
L
CSNLFGDILSD
EC
A
M
I
TG
S
M
G
ML
PSA
S
LN
-
E
QG
F
-
G
L
Y
EP
A
G
GSAPDIAGKNIANPIA
Q
ILS
L
A
LL
LR
Y
S
L
DA
D
D
-
---
AA
CA
I
ER
AI
N
R
A
L
EE
G
IR
T
G
D
LA
R
---
GAA
AVS
T
D
E
M
GD
I
I
A
R
YVAEGV
fig|413997.3.peg.80
Escherichia coli B str. REL606
MSKN
YH
IA
V
L
PGDGIG
P
EV
M
T
QA
LKVLDA
V
R
N
R
F
---
AMR
I
T
TSHYDV
G
GAA
-
IDN
HGQ
P
--
LP
PA
T
V
E
GCE
Q
A
DA
VL
FG
S
VG
GPK
W
EHLP
PD
QQ
P
ER
G
A
L
----
L
P
LR
K
H
F
K
L
F
S
NLRP
AK
LYQG
L
EAF
CPL
R
A
D
I
A
A
NGF
D
ILC
VRE
L
T
G
GIY
F
GQPK
GR
EG
SG
-
Q
Y
EK
AF
DTE
V
Y
H
R
F
E
I
-----------------------
E
RI
A
R
I
AFE
S
A
RK
R
-
R
HK
VTS
ID
K
A
N
V
L
QS
S
I-L
W
R
E
I
V
NE
IA
T
EY
--------------------
P
DV
ELAHMY
ID
NATM
Q
L
I
KD
P
S
QFDV
L
L
CSNLFGDILSD
EC
A
M
I
TG
S
M
G
ML
PSA
S
LN
-
E
QG
F
-
G
L
Y
EP
A
G
GSAPDIAGKNIANPIA
Q
ILS
L
A
LL
LR
Y
S
L
DA
D
D
-
---
AA
CA
I
ER
AI
N
R
A
L
EE
G
IR
T
G
D
LA
R
---
GAA
AVS
T
D
E
M
GD
I
I
A
R
YVAEGV
fig|550672.3.peg.4346
Escherichia coli B088
MSKN
YH
IA
V
L
PGDGIG
P
EV
M
T
QA
LKVLDA
V
R
N
R
F
---
AMR
I
T
TSHYDV
G
GAA
-
IDN
HGQ
P
--
LP
PA
T
V
E
GCE
Q
A
DA
VL
FG
S
VG
GPK
W
EHLP
PD
QQ
P
ER
G
A
L
----
L
P
LR
K
H
F
K
L
F
S
NLRP
AK
LYQG
L
EAF
CPL
R
A
D
I
A
A
NGF
D
ILC
VRE
L
T
G
GIY
F
GQPK
GR
EG
SG
-
Q
Y
EK
AF
DTE
V
Y
H
R
F
E
I
-----------------------
E
RI
A
R
I
AFE
S
A
RK
R
-
R
HK
VTS
ID
K
A
N
V
L
QS
S
I-L
W
R
E
I
V
NE
IA
T
EY
--------------------
P
DV
ELAHMY
ID
NATM
Q
L
I
KD
P
S
QFDV
L
L
CSNLFGDILSD
EC
A
M
I
TG
S
M
G
ML
PSA
S
LN
-
E
QG
F
-
G
L
Y
EP
A
G
GSAPDIAGKNIANPIA
Q
ILS
L
A
LL
LR
Y
S
L
DA
D
D
-
---
AA
CA
I
ER
AI
N
R
A
L
EE
G
IR
T
G
D
LA
R
---
GAA
AVS
T
D
E
M
GD
I
I
A
R
YVAEGV
fig|344601.3.peg.3706
Escherichia coli B171
MSKN
YH
IA
V
L
PGDGIG
P
EV
M
T
QA
LKVLDA
V
R
N
R
F
---
AMR
I
T
TSHYDV
G
GAA
-
IDN
HGQ
P
--
LP
PA
T
V
E
GCE
Q
A
DA
VL
FG
S
VG
GPK
W
EHLP
PD
QQ
P
ER
G
A
L
----
L
P
LR
K
H
F
K
L
F
S
NLRP
AK
LYQG
L
EAF
CPL
R
A
D
I
A
A
NGF
D
ILC
VRE
L
T
G
GIY
F
GQPK
GR
EG
SG
-
Q
Y
EK
AF
DTE
V
Y
H
R
F
E
I
-----------------------
E
RI
A
R
I
AFE
S
A
RK
R
-
R
HK
VTS
ID
K
A
N
V
L
QS
S
I-L
W
R
E
I
V
NE
IA
T
EY
--------------------
P
DV
ELAHMY
ID
NATM
Q
L
I
KD
P
S
QFDV
L
L
CSNLFGDILSD
EC
A
M
I
TG
S
M
G
ML
PSA
S
LN
-
E
QG
F
-
G
L
Y
EP
A
G
GSAPDIAGKNIANPIA
Q
ILS
L
A
LL
LR
Y
S
L
DA
D
D
-
---
AA
CA
I
ER
AI
N
R
A
L
EE
G
IR
T
G
D
LA
R
---
GAA
AVS
T
D
E
M
GD
I
I
A
R
YVAEGV
fig|344601.5.peg.3875
Escherichia coli B171
MSKN
YH
IA
V
L
PGDGIG
P
EV
M
T
QA
LKVLDA
V
R
N
R
F
---
AMR
I
T
TSHYDV
G
GAA
-
IDN
HGQ
P
--
LP
PA
T
V
E
GCE
Q
A
DA
VL
FG
S
VG
GPK
W
EHLP
PD
QQ
P
ER
G
A
L
----
L
P
LR
K
H
F
K
L
F
S
NLRP
AK
LYQG
L
EAF
CPL
R
A
D
I
A
A
NGF
D
ILC
VRE
L
T
G
GIY
F
GQPK
GR
EG
SG
-
Q
Y
EK
AF
DTE
V
Y
H
R
F
E
I
-----------------------
E
RI
A
R
I
AFE
S
A
RK
R
-
R
HK
VTS
ID
K
A
N
V
L
QS
S
I-L
W
R
E
I
V
NE
IA
T
EY
--------------------
P
DV
ELAHMY
ID
NATM
Q
L
I
KD
P
S
QFDV
L
L
CSNLFGDILSD
EC
A
M
I
TG
S
M
G
ML
PSA
S
LN
-
E
QG
F
-
G
L
Y
EP
A
G
GSAPDIAGKNIANPIA
Q
ILS
L
A
LL
LR
Y
S
L
DA
D
D
-
---
AA
CA
I
ER
AI
N
R
A
L
EE
G
IR
T
G
D
LA
R
---
GAA
AVS
T
D
E
M
GD
I
I
A
R
YVAEGV
fig|340184.3.peg.2852
Escherichia coli B7A
MSKN
YH
IA
V
L
PGDGIG
P
EV
M
T
QA
LKVLDA
V
R
N
R
F
---
AMR
I
T
TSHYDV
G
GAA
-
IDN
HGQ
P
--
LP
PA
T
V
E
GCE
Q
A
DA
VL
FG
S
VG
GPK
W
EHLP
PD
QQ
P
ER
G
A
L
----
L
P
LR
K
H
F
K
L
F
S
NLRP
AK
LYQG
L
EAF
CPL
R
A
D
I
A
A
NGF
D
ILC
VRE
L
T
G
GIY
F
GQPK
GR
EG
SG
-
Q
Y
EK
AF
DTE
V
Y
H
R
F
E
I
-----------------------
E
RI
A
R
I
AFE
S
A
RK
R
-
R
HK
VTS
ID
K
A
N
V
L
QS
S
I-L
W
R
E
I
V
NE
IA
T
EY
--------------------
P
DV
ELAHMY
ID
NATM
Q
L
I
KD
P
S
QFDV
L
L
CSNLFGDILSD
EC
A
M
I
TG
S
M
G
ML
PSA
S
LN
-
E
QG
F
-
G
L
Y
EP
A
G
GSAPDIAGKNIANPIA
Q
ILS
L
A
LL
LR
Y
S
L
DA
D
D
-
---
AA
CA
I
ER
AI
N
R
A
L
EE
G
IR
T
G
D
LA
R
---
GAA
AVS
T
D
E
M
GD
I
I
A
R
YVAEGV
fig|340184.6.peg.2984
Escherichia coli B7A
MSKN
YH
IA
V
L
PGDGIG
P
EV
M
T
QA
LKVLDA
V
R
N
R
F
---
AMR
I
T
TSHYDV
G
GAA
-
IDN
HGQ
P
--
LP
PA
T
V
E
GCE
Q
A
DA
VL
FG
S
VG
GPK
W
EHLP
PD
QQ
P
ER
G
A
L
----
L
P
LR
K
H
F
K
L
F
S
NLRP
AK
LYQG
L
EAF
CPL
R
A
D
I
A
A
NGF
D
ILC
VRE
L
T
G
GIY
F
GQPK
GR
EG
SG
-
Q
Y
EK
AF
DTE
V
Y
H
R
F
E
I
-----------------------
E
RI
A
R
I
AFE
S
A
RK
R
-
R
HK
VTS
ID
K
A
N
V
L
QS
S
I-L
W
R
E
I
V
NE
IA
T
EY
--------------------
P
DV
ELAHMY
ID
NATM
Q
L
I
KD
P
S
QFDV
L
L
CSNLFGDILSD
EC
A
M
I
TG
S
M
G
ML
PSA
S
LN
-
E
QG
F
-
G
L
Y
EP
A
G
GSAPDIAGKNIANPIA
Q
ILS
L
A
LL
LR
Y
S
L
DA
D
D
-
---
AA
CA
I
ER
AI
N
R
A
L
EE
G
IR
T
G
D
LA
R
---
GAA
AVS
T
D
E
M
GD
I
I
A
R
YVAEGV
fig|511693.5.peg.81
Escherichia coli BL21
MSKN
YH
IA
V
L
PGDGIG
P
EV
M
T
QA
LKVLDA
V
R
N
R
F
---
AMR
I
T
TSHYDV
G
GAA
-
IDN
HGQ
P
--
LP
PA
T
V
E
GCE
Q
A
DA
VL
FG
S
VG
GPK
W
EHLP
PD
QQ
P
ER
G
A
L
----
L
P
LR
K
H
F
K
L
F
S
NLRP
AK
LYQG
L
EAF
CPL
R
A
D
I
A
A
NGF
D
ILC
VRE
L
T
G
GIY
F
GQPK
GR
EG
SG
-
Q
Y
EK
AF
DTE
V
Y
H
R
F
E
I
-----------------------
E
RI
A
R
I
AFE
S
A
RK
R
-
R
HK
VTS
ID
K
A
N
V
L
QS
S
I-L
W
R
E
I
V
NE
IA
T
EY
--------------------
P
DV
ELAHMY
ID
NATM
Q
L
I
KD
P
S
QFDV
L
L
CSNLFGDILSD
EC
A
M
I
TG
S
M
G
ML
PSA
S
LN
-
E
QG
F
-
G
L
Y
EP
A
G
GSAPDIAGKNIANPIA
Q
ILS
L
A
LL
LR
Y
S
L
DA
D
D
-
---
AA
CA
I
ER
AI
N
R
A
L
EE
G
IR
T
G
D
LA
R
---
GAA
AVS
T
D
E
M
GD
I
I
A
R
YVAEGV
fig|469008.4.peg.3664
Escherichia coli BL21(DE3)
MSKN
YH
IA
V
L
PGDGIG
P
EV
M
T
QA
LKVLDA
V
R
N
R
F
---
AMR
I
T
TSHYDV
G
GAA
-
IDN
HGQ
P
--
LP
PA
T
V
E
GCE
Q
A
DA
VL
FG
S
VG
GPK
W
EHLP
PD
QQ
P
ER
G
A
L
----
L
P
LR
K
H
F
K
L
F
S
NLRP
AK
LYQG
L
EAF
CPL
R
A
D
I
A
A
NGF
D
ILC
VRE
L
T
G
GIY
F
GQPK
GR
EG
SG
-
Q
Y
EK
AF
DTE
V
Y
H
R
F
E
I
-----------------------
E
RI
A
R
I
AFE
S
A
RK
R
-
R
HK
VTS
ID
K
A
N
V
L
QS
S
I-L
W
R
E
I
V
NE
IA
T
EY
--------------------
P
DV
ELAHMY
ID
NATM
Q
L
I
KD
P
S
QFDV
L
L
CSNLFGDILSD
EC
A
M
I
TG
S
M
G
ML
PSA
S
LN
-
E
QG
F
-
G
L
Y
EP
A
G
GSAPDIAGKNIANPIA
Q
ILS
L
A
LL
LR
Y
S
L
DA
D
D
-
---
AA
CA
I
ER
AI
N
R
A
L
EE
G
IR
T
G
D
LA
R
---
GAA
AVS
T
D
E
M
GD
I
I
A
R
YVAEGV
fig|595496.3.peg.78
Escherichia coli BW2952
MSKN
YH
IA
V
L
PGDGIG
P
EV
M
T
QA
LKVLDA
V
R
N
R
F
---
AMR
I
T
TSHYDV
G
GAA
-
IDN
HGQ
P
--
LP
PA
T
V
E
GCE
Q
A
DA
VL
FG
S
VG
GPK
W
EHLP
PD
QQ
P
ER
G
A
L
----
L
P
LR
K
H
F
K
L
F
S
NLRP
AK
LYQG
L
EAF
CPL
R
A
D
I
A
A
NGF
D
ILC
VRE
L
T
G
GIY
F
GQPK
GR
EG
SG
-
Q
Y
EK
AF
DTE
V
Y
H
R
F
E
I
-----------------------
E
RI
A
R
I
AFE
S
A
RK
R
-
R
HK
VTS
ID
K
A
N
V
L
QS
S
I-L
W
R
E
I
V
NE
IA
T
EY
--------------------
P
DV
ELAHMY
ID
NATM
Q
L
I
KD
P
S
QFDV
L
L
CSNLFGDILSD
EC
A
M
I
TG
S
M
G
ML
PSA
S
LN
-
E
QG
F
-
G
L
Y
EP
A
G
GSAPDIAGKNIANPIA
Q
ILS
L
A
LL
LR
Y
S
L
DA
D
D
-
---
AA
CA
I
ER
AI
N
R
A
L
EE
G
IR
T
G
D
LA
R
---
GAA
AVS
T
D
E
M
GD
I
I
A
R
YVAEGV
fig|536056.3.peg.3727
Escherichia coli DH1
MSKN
YH
IA
V
L
PGDGIG
P
EV
M
T
QA
LKVLDA
V
R
N
R
F
---
AMR
I
T
TSHYDV
G
GAA
-
IDN
HGQ
P
--
LP
PA
T
V
E
GCE
Q
A
DA
VL
FG
S
VG
GPK
W
EHLP
PD
QQ
P
ER
G
A
L
----
L
P
LR
K
H
F
K
L
F
S
NLRP
AK
LYQG
L
EAF
CPL
R
A
D
I
A
A
NGF
D
ILC
VRE
L
T
G
GIY
F
GQPK
GR
EG
SG
-
Q
Y
EK
AF
DTE
V
Y
H
R
F
E
I
-----------------------
E
RI
A
R
I
AFE
S
A
RK
R
-
R
HK
VTS
ID
K
A
N
V
L
QS
S
I-L
W
R
E
I
V
NE
IA
T
EY
--------------------
P
DV
ELAHMY
ID
NATM
Q
L
I
KD
P
S
QFDV
L
L
CSNLFGDILSD
EC
A
M
I
TG
S
M
G
ML
PSA
S
LN
-
E
QG
F
-
G
L
Y
EP
A
G
GSAPDIAGKNIANPIA
Q
ILS
L
A
LL
LR
Y
S
L
DA
D
D
-
---
AA
CA
I
ER
AI
N
R
A
L
EE
G
IR
T
G
D
LA
R
---
GAA
AVS
T
D
E
M
GD
I
I
A
R
YVAEGV
fig|340185.3.peg.4259
Escherichia coli E22
MSKN
YH
IA
V
L
PGDGIG
P
EV
M
T
QA
LKVLDA
V
R
N
R
F
---
AMR
I
T
TSHYDV
G
GAA
-
IDN
HGQ
P
--
LP
PA
T
V
E
GCE
Q
A
DA
VL
FG
S
VG
GPK
W
EHLP
PD
QQ
P
ER
G
A
L
----
L
P
LR
K
H
F
K
L
F
S
NLRP
AK
LYQG
L
EAF
CPL
R
A
D
I
A
A
NGF
D
ILC
VRE
L
T
G
GIY
F
GQPK
GR
EG
SG
-
Q
Y
EK
AF
DTE
V
Y
H
R
F
E
I
-----------------------
E
RI
A
R
I
AFE
S
A
RK
R
-
R
HK
VTS
ID
K
A
N
V
L
QS
S
I-L
W
R
E
I
V
NE
IA
T
EY
--------------------
P
DV
ELAHMY
ID
NATM
Q
L
I
KD
P
S
QFDV
L
L
CSNLFGDILSD
EC
A
M
I
TG
S
M
G
ML
PSA
S
LN
-
E
QG
F
-
G
L
Y
EP
A
G
GSAPDIAGKNIANPIA
Q
ILS
L
A
LL
LR
Y
S
L
DA
D
D
-
---
AA
CA
I
ER
AI
N
R
A
L
EE
G
IR
T
G
D
LA
R
---
GAA
AVS
T
D
E
M
GD
I
I
A
R
YVAEGV
fig|340185.4.peg.4492
Escherichia coli E22
MSKN
YH
IA
V
L
PGDGIG
P
EV
M
T
QA
LKVLDA
V
R
N
R
F
---
AMR
I
T
TSHYDV
G
GAA
-
IDN
HGQ
P
--
LP
PA
T
V
E
GCE
Q
A
DA
VL
FG
S
VG
GPK
W
EHLP
PD
QQ
P
ER
G
A
L
----
L
P
LR
K
H
F
K
L
F
S
NLRP
AK
LYQG
L
EAF
CPL
R
A
D
I
A
A
NGF
D
ILC
VRE
L
T
G
GIY
F
GQPK
GR
EG
SG
-
Q
Y
EK
AF
DTE
V
Y
H
R
F
E
I
-----------------------
E
RI
A
R
I
AFE
S
A
RK
R
-
R
HK
VTS
ID
K
A
N
V
L
QS
S
I-L
W
R
E
I
V
NE
IA
T
EY
--------------------
P
DV
ELAHMY
ID
NATM
Q
L
I
KD
P
S
QFDV
L
L
CSNLFGDILSD
EC
A
M
I
TG
S
M
G
ML
PSA
S
LN
-
E
QG
F
-
G
L
Y
EP
A
G
GSAPDIAGKNIANPIA
Q
ILS
L
A
LL
LR
Y
S
L
DA
D
D
-
---
AA
CA
I
ER
AI
N
R
A
L
EE
G
IR
T
G
D
LA
R
---
GAA
AVS
T
D
E
M
GD
I
I
A
R
YVAEGV
fig|331111.12.peg.406
Escherichia coli E24377A
MSKN
YH
IA
V
L
PGDGIG
P
EV
M
T
QA
LKVLDA
V
R
N
R
F
---
AMR
I
T
TSHYDV
G
GAA
-
IDN
HGQ
P
--
LP
PA
T
V
E
GCE
Q
A
DA
VL
FG
S
VG
GPK
W
EHLP
PD
QQ
P
ER
G
A
L
----
L
P
LR
K
H
F
K
L
F
S
NLRP
AK
LYQG
L
EAF
CPL
R
A
D
I
A
A
NGF
D
ILC
VRE
L
T
G
GIY
F
GQPK
GR
EG
SG
-
Q
Y
EK
AF
DTE
V
Y
H
R
F
E
I
-----------------------
E
RI
A
R
I
AFE
S
A
RK
R
-
R
HK
VTS
ID
K
A
N
V
L
QS
S
I-L
W
R
E
I
V
NE
IA
T
EY
--------------------
P
DV
ELAHMY
ID
NATM
Q
L
I
KD
P
S
QFDV
L
L
CSNLFGDILSD
EC
A
M
I
TG
S
M
G
ML
PSA
S
LN
-
E
QG
F
-
G
L
Y
EP
A
G
GSAPDIAGKNIANPIA
Q
ILS
L
A
LL
LR
Y
S
L
DA
D
D
-
---
AA
CA
I
ER
AI
N
R
A
L
EE
G
IR
T
G
D
LA
R
---
GAA
AVS
T
D
E
M
GD
I
I
A
R
YVAEGV
fig|331111.3.peg.2645
Escherichia coli E24377A
MSKN
YH
IA
V
L
PGDGIG
P
EV
M
T
QA
LKVLDA
V
R
N
R
F
---
AMR
I
T
TSHYDV
G
GAA
-
IDN
HGQ
P
--
LP
PA
T
V
E
GCE
Q
A
DA
VL
FG
S
VG
GPK
W
EHLP
PD
QQ
P
ER
G
A
L
----
L
P
LR
K
H
F
K
L
F
S
NLRP
AK
LYQG
L
EAF
CPL
R
A
D
I
A
A
NGF
D
ILC
VRE
L
T
G
GIY
F
GQPK
GR
EG
SG
-
Q
Y
EK
AF
DTE
V
Y
H
R
F
E
I
-----------------------
E
RI
A
R
I
AFE
S
A
RK
R
-
R
HK
VTS
ID
K
A
N
V
L
QS
S
I-L
W
R
E
I
V
NE
IA
T
EY
--------------------
P
DV
ELAHMY
ID
NATM
Q
L
I
KD
P
S
QFDV
L
L
CSNLFGDILSD
EC
A
M
I
TG
S
M
G
ML
PSA
S
LN
-
E
QG
F
-
G
L
Y
EP
A
G
GSAPDIAGKNIANPIA
Q
ILS
L
A
LL
LR
Y
S
L
DA
D
D
-
---
AA
CA
I
ER
AI
N
R
A
L
EE
G
IR
T
G
D
LA
R
---
GAA
AVS
T
D
E
M
GD
I
I
A
R
YVAEGV
fig|562.375.peg.2581
Escherichia coli EC4100B
MSKN
YH
IA
V
L
PGDGIG
P
EV
M
T
QA
LKVLDA
V
R
N
R
F
---
AMR
I
T
TSHYDV
G
GAA
-
IDN
HGQ
P
--
LP
PA
T
V
E
GCE
Q
A
DA
VL
FG
S
VG
GPK
W
EHLP
PD
QQ
P
ER
G
A
L
----
L
P
LR
K
H
F
K
L
F
S
NLRP
AK
LYQG
L
EAF
CPL
R
A
D
I
A
A
NGF
D
ILC
VRE
L
T
G
GIY
F
GQPK
GR
EG
SG
-
Q
Y
EK
AF
DTE
V
Y
H
R
F
E
I
-----------------------
E
RI
A
R
I
AFE
S
A
RK
R
-
R
HK
VTS
ID
K
A
N
V
L
QS
S
I-L
W
R
E
I
V
NE
IA
T
EY
--------------------
P
DV
ELAHMY
ID
NATM
Q
L
I
KD
P
S
QFDV
L
L
CSNLFGDILSD
EC
A
M
I
TG
S
M
G
ML
PSA
S
LN
-
E
QG
F
-
G
L
Y
EP
A
G
GSAPDIAGKNIANPIA
Q
ILS
L
A
LL
LR
Y
S
L
DA
D
D
-
---
AA
CA
I
ER
AI
N
R
A
L
EE
G
IR
T
G
D
LA
R
---
GAA
AVS
T
D
E
M
GD
I
I
A
R
YVAEGV
fig|316401.4.peg.80
Escherichia coli ETEC H10407
MSKN
YH
IA
V
L
PGDGIG
P
EV
M
T
QA
LKVLDA
V
R
N
R
F
---
AMR
I
T
TSHYDV
G
GAA
-
IDN
HGQ
P
--
LP
PA
T
V
E
GCE
Q
A
DA
VL
FG
S
VG
GPK
W
EHLP
PD
QQ
P
ER
G
A
L
----
L
P
LR
K
H
F
K
L
F
S
NLRP
AK
LYQG
L
EAF
CPL
R
A
D
I
A
A
NGF
D
ILC
VRE
L
T
G
GIY
F
GQPK
GR
EG
SG
-
Q
Y
EK
AF
DTE
V
Y
H
R
F
E
I
-----------------------
E
RI
A
R
I
AFE
S
A
RK
R
-
R
HK
VTS
ID
K
A
N
V
L
QS
S
I-L
W
R
E
I
V
NE
IA
T
EY
--------------------
P
DV
ELAHMY
ID
NATM
Q
L
I
KD
P
S
QFDV
L
L
CSNLFGDILSD
EC
A
M
I
TG
S
M
G
ML
PSA
S
LN
-
E
QG
F
-
G
L
Y
EP
A
G
GSAPDIAGKNIANPIA
Q
ILS
L
A
LL
LR
Y
S
L
DA
D
D
-
---
AA
CA
I
ER
AI
N
R
A
L
EE
G
IR
T
G
D
LA
R
---
GAA
AVS
T
D
E
M
GD
I
I
A
R
YVAEGV
fig|656408.3.peg.5025
Escherichia coli H591
MSKN
YH
IA
V
L
PGDGIG
P
EV
M
T
QA
LKVLDA
V
R
N
R
F
---
AMR
I
T
TSHYDV
G
GAA
-
IDN
HGQ
P
--
LP
PA
T
V
E
GCE
Q
A
DA
VL
FG
S
VG
GPK
W
EHLP
PD
QQ
P
ER
G
A
L
----
L
P
LR
K
H
F
K
L
F
S
NLRP
AK
LYQG
L
EAF
CPL
R
A
D
I
A
A
NGF
D
ILC
VRE
L
T
G
GIY
F
GQPK
GR
EG
SG
-
Q
Y
EK
AF
DTE
V
Y
H
R
F
E
I
-----------------------
E
RI
A
R
I
AFE
S
A
RK
R
-
R
HK
VTS
ID
K
A
N
V
L
QS
S
I-L
W
R
E
I
V
NE
IA
T
EY
--------------------
P
DV
ELAHMY
ID
NATM
Q
L
I
KD
P
S
QFDV
L
L
CSNLFGDILSD
EC
A
M
I
TG
S
M
G
ML
PSA
S
LN
-
E
QG
F
-
G
L
Y
EP
A
G
GSAPDIAGKNIANPIA
Q
ILS
L
A
LL
LR
Y
S
L
DA
D
D
-
---
AA
CA
I
ER
AI
N
R
A
L
EE
G
IR
T
G
D
LA
R
---
GAA
AVS
T
D
E
M
GD
I
I
A
R
YVAEGV
fig|656414.3.peg.192
Escherichia coli H736
MSKN
YH
IA
V
L
PGDGIG
P
EV
M
T
QA
LKVLDA
V
R
N
R
F
---
AMR
I
T
TSHYDV
G
GAA
-
IDN
HGQ
P
--
LP
PA
T
V
E
GCE
Q
A
DA
VL
FG
S
VG
GPK
W
EHLP
PD
QQ
P
ER
G
A
L
----
L
P
LR
K
H
F
K
L
F
S
NLRP
AK
LYQG
L
EAF
CPL
R
A
D
I
A
A
NGF
D
ILC
VRE
L
T
G
GIY
F
GQPK
GR
EG
SG
-
Q
Y
EK
AF
DTE
V
Y
H
R
F
E
I
-----------------------
E
RI
A
R
I
AFE
S
A
RK
R
-
R
HK
VTS
ID
K
A
N
V
L
QS
S
I-L
W
R
E
I
V
NE
IA
T
EY
--------------------
P
DV
ELAHMY
ID
NATM
Q
L
I
KD
P
S
QFDV
L
L
CSNLFGDILSD
EC
A
M
I
TG
S
M
G
ML
PSA
S
LN
-
E
QG
F
-
G
L
Y
EP
A
G
GSAPDIAGKNIANPIA
Q
ILS
L
A
LL
LR
Y
S
L
DA
D
D
-
---
AA
CA
I
ER
AI
N
R
A
L
EE
G
IR
T
G
D
LA
R
---
GAA
AVS
T
D
E
M
GD
I
I
A
R
YVAEGV
fig|331112.3.peg.74
Escherichia coli HS
MSKN
YH
IA
V
L
PGDGIG
P
EV
M
T
QA
LKVLDA
V
R
N
R
F
---
AMR
I
T
TSHYDV
G
GAA
-
IDN
HGQ
P
--
LP
PA
T
V
E
GCE
Q
A
DA
VL
FG
S
VG
GPK
W
EHLP
PD
QQ
P
ER
G
A
L
----
L
P
LR
K
H
F
K
L
F
S
NLRP
AK
LYQG
L
EAF
CPL
R
A
D
I
A
A
NGF
D
ILC
VRE
L
T
G
GIY
F
GQPK
GR
EG
SG
-
Q
Y
EK
AF
DTE
V
Y
H
R
F
E
I
-----------------------
E
RI
A
R
I
AFE
S
A
RK
R
-
R
HK
VTS
ID
K
A
N
V
L
QS
S
I-L
W
R
E
I
V
NE
IA
T
EY
--------------------
P
DV
ELAHMY
ID
NATM
Q
L
I
KD
P
S
QFDV
L
L
CSNLFGDILSD
EC
A
M
I
TG
S
M
G
ML
PSA
S
LN
-
E
QG
F
-
G
L
Y
EP
A
G
GSAPDIAGKNIANPIA
Q
ILS
L
A
LL
LR
Y
S
L
DA
D
D
-
---
AA
CA
I
ER
AI
N
R
A
L
EE
G
IR
T
G
D
LA
R
---
GAA
AVS
T
D
E
M
GD
I
I
A
R
YVAEGV
fig|331112.6.peg.79
Escherichia coli HS
MSKN
YH
IA
V
L
PGDGIG
P
EV
M
T
QA
LKVLDA
V
R
N
R
F
---
AMR
I
T
TSHYDV
G
GAA
-
IDN
HGQ
P
--
LP
PA
T
V
E
GCE
Q
A
DA
VL
FG
S
VG
GPK
W
EHLP
PD
QQ
P
ER
G
A
L
----
L
P
LR
K
H
F
K
L
F
S
NLRP
AK
LYQG
L
EAF
CPL
R
A
D
I
A
A
NGF
D
ILC
VRE
L
T
G
GIY
F
GQPK
GR
EG
SG
-
Q
Y
EK
AF
DTE
V
Y
H
R
F
E
I
-----------------------
E
RI
A
R
I
AFE
S
A
RK
R
-
R
HK
VTS
ID
K
A
N
V
L
QS
S
I-L
W
R
E
I
V
NE
IA
T
EY
--------------------
P
DV
ELAHMY
ID
NATM
Q
L
I
KD
P
S
QFDV
L
L
CSNLFGDILSD
EC
A
M
I
TG
S
M
G
ML
PSA
S
LN
-
E
QG
F
-
G
L
Y
EP
A
G
GSAPDIAGKNIANPIA
Q
ILS
L
A
LL
LR
Y
S
L
DA
D
D
-
---
AA
CA
I
ER
AI
N
R
A
L
EE
G
IR
T
G
D
LA
R
---
GAA
AVS
T
D
E
M
GD
I
I
A
R
YVAEGV
fig|585034.4.peg.75
Escherichia coli IAI1
MSKN
YH
IA
V
L
PGDGIG
P
EV
M
T
QA
LKVLDA
V
R
N
R
F
---
AMR
I
T
TSHYDV
G
GAA
-
IDN
HGQ
P
--
LP
PA
T
V
E
GCE
Q
A
DA
VL
FG
S
VG
GPK
W
EHLP
PD
QQ
P
ER
G
A
L
----
L
P
LR
K
H
F
K
L
F
S
NLRP
AK
LYQG
L
EAF
CPL
R
A
D
I
A
A
NGF
D
ILC
VRE
L
T
G
GIY
F
GQPK
GR
EG
SG
-
Q
Y
EK
AF
DTE
V
Y
H
R
F
E
I
-----------------------
E
RI
A
R
I
AFE
S
A
RK
R
-
R
HK
VTS
ID
K
A
N
V
L
QS
S
I-L
W
R
E
I
V
NE
IA
T
EY
--------------------
P
DV
ELAHMY
ID
NATM
Q
L
I
KD
P
S
QFDV
L
L
CSNLFGDILSD
EC
A
M
I
TG
S
M
G
ML
PSA
S
LN
-
E
QG
F
-
G
L
Y
EP
A
G
GSAPDIAGKNIANPIA
Q
ILS
L
A
LL
LR
Y
S
L
DA
D
D
-
---
AA
CA
I
ER
AI
N
R
A
L
EE
G
IR
T
G
D
LA
R
---
GAA
AVS
T
D
E
M
GD
I
I
A
R
YVAEGV
fig|585034.5.peg.75
Escherichia coli IAI1
MSKN
YH
IA
V
L
PGDGIG
P
EV
M
T
QA
LKVLDA
V
R
N
R
F
---
AMR
I
T
TSHYDV
G
GAA
-
IDN
HGQ
P
--
LP
PA
T
V
E
GCE
Q
A
DA
VL
FG
S
VG
GPK
W
EHLP
PD
QQ
P
ER
G
A
L
----
L
P
LR
K
H
F
K
L
F
S
NLRP
AK
LYQG
L
EAF
CPL
R
A
D
I
A
A
NGF
D
ILC
VRE
L
T
G
GIY
F
GQPK
GR
EG
SG
-
Q
Y
EK
AF
DTE
V
Y
H
R
F
E
I
-----------------------
E
RI
A
R
I
AFE
S
A
RK
R
-
R
HK
VTS
ID
K
A
N
V
L
QS
S
I-L
W
R
E
I
V
NE
IA
T
EY
--------------------
P
DV
ELAHMY
ID
NATM
Q
L
I
KD
P
S
QFDV
L
L
CSNLFGDILSD
EC
A
M
I
TG
S
M
G
ML
PSA
S
LN
-
E
QG
F
-
G
L
Y
EP
A
G
GSAPDIAGKNIANPIA
Q
ILS
L
A
LL
LR
Y
S
L
DA
D
D
-
---
AA
CA
I
ER
AI
N
R
A
L
EE
G
IR
T
G
D
LA
R
---
GAA
AVS
T
D
E
M
GD
I
I
A
R
YVAEGV
fig|83333.1.peg.74
Escherichia coli K12
MSKN
YH
IA
V
L
PGDGIG
P
EV
M
T
QA
LKVLDA
V
R
N
R
F
---
AMR
I
T
TSHYDV
G
GAA
-
IDN
HGQ
P
--
LP
PA
T
V
E
GCE
Q
A
DA
VL
FG
S
VG
GPK
W
EHLP
PD
QQ
P
ER
G
A
L
----
L
P
LR
K
H
F
K
L
F
S
NLRP
AK
LYQG
L
EAF
CPL
R
A
D
I
A
A
NGF
D
ILC
VRE
L
T
G
GIY
F
GQPK
GR
EG
SG
-
Q
Y
EK
AF
DTE
V
Y
H
R
F
E
I
-----------------------
E
RI
A
R
I
AFE
S
A
RK
R
-
R
HK
VTS
ID
K
A
N
V
L
QS
S
I-L
W
R
E
I
V
NE
IA
T
EY
--------------------
P
DV
ELAHMY
ID
NATM
Q
L
I
KD
P
S
QFDV
L
L
CSNLFGDILSD
EC
A
M
I
TG
S
M
G
ML
PSA
S
LN
-
E
QG
F
-
G
L
Y
EP
A
G
GSAPDIAGKNIANPIA
Q
ILS
L
A
LL
LR
Y
S
L
DA
D
D
-
---
AA
CA
I
ER
AI
N
R
A
L
EE
G
IR
T
G
D
LA
R
---
GAA
AVS
T
D
E
M
GD
I
I
A
R
YVAEGV
fig|656419.3.peg.230
Escherichia coli M718
MSKN
YH
IA
V
L
PGDGIG
P
EV
M
T
QA
LKVLDA
V
R
N
R
F
---
AMR
I
T
TSHYDV
G
GAA
-
IDN
HGQ
P
--
LP
PA
T
V
E
GCE
Q
A
DA
VL
FG
S
VG
GPK
W
EHLP
PD
QQ
P
ER
G
A
L
----
L
P
LR
K
H
F
K
L
F
S
NLRP
AK
LYQG
L
EAF
CPL
R
A
D
I
A
A
NGF
D
ILC
VRE
L
T
G
GIY
F
GQPK
GR
EG
SG
-
Q
Y
EK
AF
DTE
V
Y
H
R
F
E
I
-----------------------
E
RI
A
R
I
AFE
S
A
RK
R
-
R
HK
VTS
ID
K
A
N
V
L
QS
S
I-L
W
R
E
I
V
NE
IA
T
EY
--------------------
P
DV
ELAHMY
ID
NATM
Q
L
I
KD
P
S
QFDV
L
L
CSNLFGDILSD
EC
A
M
I
TG
S
M
G
ML
PSA
S
LN
-
E
QG
F
-
G
L
Y
EP
A
G
GSAPDIAGKNIANPIA
Q
ILS
L
A
LL
LR
Y
S
L
DA
D
D
-
---
AA
CA
I
ER
AI
N
R
A
L
EE
G
IR
T
G
D
LA
R
---
GAA
AVS
T
D
E
M
GD
I
I
A
R
YVAEGV
fig|679207.4.peg.1111
Escherichia coli MS 107-1
MSKN
YH
IA
V
L
PGDGIG
P
EV
M
T
QA
LKVLDA
V
R
N
R
F
---
AMR
I
T
TSHYDV
G
GAA
-
IDN
HGQ
P
--
LP
PA
T
V
E
GCE
Q
A
DA
VL
FG
S
VG
GPK
W
EHLP
PD
QQ
P
ER
G
A
L
----
L
P
LR
K
H
F
K
L
F
S
NLRP
AK
LYQG
L
EAF
CPL
R
A
D
I
A
A
NGF
D
ILC
VRE
L
T
G
GIY
F
GQPK
GR
EG
SG
-
Q
Y
EK
AF
DTE
V
Y
H
R
F
E
I
-----------------------
E
RI
A
R
I
AFE
S
A
RK
R
-
R
HK
VTS
ID
K
A
N
V
L
QS
S
I-L
W
R
E
I
V
NE
IA
T
EY
--------------------
P
DV
ELAHMY
ID
NATM
Q
L
I
KD
P
S
QFDV
L
L
CSNLFGDILSD
EC
A
M
I
TG
S
M
G
ML
PSA
S
LN
-
E
QG
F
-
G
L
Y
EP
A
G
GSAPDIAGKNIANPIA
Q
ILS
L
A
LL
LR
Y
S
L
DA
D
D
-
---
AA
CA
I
ER
AI
N
R
A
L
EE
G
IR
T
G
D
LA
R
---
GAA
AVS
T
D
E
M
GD
I
I
A
R
YVAEGV
fig|749537.3.peg.3167
Escherichia coli MS 115-1
MSKN
YH
IA
V
L
PGDGIG
P
EV
M
T
QA
LKVLDA
V
R
N
R
F
---
AMR
I
T
TSHYDV
G
GAA
-
IDN
HGQ
P
--
LP
PA
T
V
E
GCE
Q
A
DA
VL
FG
S
VG
GPK
W
EHLP
PD
QQ
P
ER
G
A
L
----
L
P
LR
K
H
F
K
L
F
S
NLRP
AK
LYQG
L
EAF
CPL
R
A
D
I
A
A
NGF
D
ILC
VRE
L
T
G
GIY
F
GQPK
GR
EG
SG
-
Q
Y
EK
AF
DTE
V
Y
H
R
F
E
I
-----------------------
E
RI
A
R
I
AFE
S
A
RK
R
-
R
HK
VTS
ID
K
A
N
V
L
QS
S
I-L
W
R
E
I
V
NE
IA
T
EY
--------------------
P
DV
ELAHMY
ID
NATM
Q
L
I
KD
P
S
QFDV
L
L
CSNLFGDILSD
EC
A
M
I
TG
S
M
G
ML
PSA
S
LN
-
E
QG
F
-
G
L
Y
EP
A
G
GSAPDIAGKNIANPIA
Q
ILS
L
A
LL
LR
Y
S
L
DA
D
D
-
---
AA
CA
I
ER
AI
N
R
A
L
EE
G
IR
T
G
D
LA
R
---
GAA
AVS
T
D
E
M
GD
I
I
A
R
YVAEGV
fig|749538.3.peg.3063
Escherichia coli MS 116-1
MSKN
YH
IA
V
L
PGDGIG
P
EV
M
T
QA
LKVLDA
V
R
N
R
F
---
AMR
I
T
TSHYDV
G
GAA
-
IDN
HGQ
P
--
LP
PA
T
V
E
GCE
Q
A
DA
VL
FG
S
VG
GPK
W
EHLP
PD
QQ
P
ER
G
A
L
----
L
P
LR
K
H
F
K
L
F
S
NLRP
AK
LYQG
L
EAF
CPL
R
A
D
I
A
A
NGF
D
ILC
VRE
L
T
G
GIY
F
GQPK
GR
EG
SG
-
Q
Y
EK
AF
DTE
V
Y
H
R
F
E
I
-----------------------
E
RI
A
R
I
AFE
S
A
RK
R
-
R
HK
VTS
ID
K
A
N
V
L
QS
S
I-L
W
R
E
I
V
NE
IA
T
EY
--------------------
P
DV
ELAHMY
ID
NATM
Q
L
I
KD
P
S
QFDV
L
L
CSNLFGDILSD
EC
A
M
I
TG
S
M
G
ML
PSA
S
LN
-
E
QG
F
-
G
L
Y
EP
A
G
GSAPDIAGKNIANPIA
Q
ILS
L
A
LL
LR
Y
S
L
DA
D
D
-
---
AA
CA
I
ER
AI
N
R
A
L
EE
G
IR
T
G
D
LA
R
---
GAA
AVS
T
D
E
M
GD
I
I
A
R
YVAEGV
fig|679206.4.peg.1699
Escherichia coli MS 119-7
MSKN
YH
IA
V
L
PGDGIG
P
EV
M
T
QA
LKVLDA
V
R
N
R
F
---
AMR
I
T
TSHYDV
G
GAA
-
IDN
HGQ
P
--
LP
PA
T
V
E
GCE
Q
A
DA
VL
FG
S
VG
GPK
W
EHLP
PD
QQ
P
ER
G
A
L
----
L
P
LR
K
H
F
K
L
F
S
NLRP
AK
LYQG
L
EAF
CPL
R
A
D
I
A
A
NGF
D
ILC
VRE
L
T
G
GIY
F
GQPK
GR
EG
SG
-
Q
Y
EK
AF
DTE
V
Y
H
R
F
E
I
-----------------------
E
RI
A
R
I
AFE
S
A
RK
R
-
R
HK
VTS
ID
K
A
N
V
L
QS
S
I-L
W
R
E
I
V
NE
IA
T
EY
--------------------
P
DV
ELAHMY
ID
NATM
Q
L
I
KD
P
S
QFDV
L
L
CSNLFGDILSD
EC
A
M
I
TG
S
M
G
ML
PSA
S
LN
-
E
QG
F
-
G
L
Y
EP
A
G
GSAPDIAGKNIANPIA
Q
ILS
L
A
LL
LR
Y
S
L
DA
D
D
-
---
AA
CA
I
ER
AI
N
R
A
L
EE
G
IR
T
G
D
LA
R
---
GAA
AVS
T
D
E
M
GD
I
I
A
R
YVAEGV
fig|679205.4.peg.2342
Escherichia coli MS 124-1
MSKN
YH
IA
V
L
PGDGIG
P
EV
M
T
QA
LKVLDA
V
R
N
R
F
---
AMR
I
T
TSHYDV
G
GAA
-
IDN
HGQ
P
--
LP
PA
T
V
E
GCE
Q
A
DA
VL
FG
S
VG
GPK
W
EHLP
PD
QQ
P
ER
G
A
L
----
L
P
LR
K
H
F
K
L
F
S
NLRP
AK
LYQG
L
EAF
CPL
R
A
D
I
A
A
NGF
D
ILC
VRE
L
T
G
GIY
F
GQPK
GR
EG
SG
-
Q
Y
EK
AF
DTE
V
Y
H
R
F
E
I
-----------------------
E
RI
A
R
I
AFE
S
A
RK
R
-
R
HK
VTS
ID
K
A
N
V
L
QS
S
I-L
W
R
E
I
V
NE
IA
T
EY
--------------------
P
DV
ELAHMY
ID
NATM
Q
L
I
KD
P
S
QFDV
L
L
CSNLFGDILSD
EC
A
M
I
TG
S
M
G
ML
PSA
S
LN
-
E
QG
F
-
G
L
Y
EP
A
G
GSAPDIAGKNIANPIA
Q
ILS
L
A
LL
LR
Y
S
L
DA
D
D
-
---
AA
CA
I
ER
AI
N
R
A
L
EE
G
IR
T
G
D
LA
R
---
GAA
AVS
T
D
E
M
GD
I
I
A
R
YVAEGV
fig|749540.3.peg.4632
Escherichia coli MS 146-1
MSKN
YH
IA
V
L
PGDGIG
P
EV
M
T
QA
LKVLDA
V
R
N
R
F
---
AMR
I
T
TSHYDV
G
GAA
-
IDN
HGQ
P
--
LP
PA
T
V
E
GCE
Q
A
DA
VL
FG
S
VG
GPK
W
EHLP
PD
QQ
P
ER
G
A
L
----
L
P
LR
K
H
F
K
L
F
S
NLRP
AK
LYQG
L
EAF
CPL
R
A
D
I
A
A
NGF
D
ILC
VRE
L
T
G
GIY
F
GQPK
GR
EG
SG
-
Q
Y
EK
AF
DTE
V
Y
H
R
F
E
I
-----------------------
E
RI
A
R
I
AFE
S
A
RK
R
-
R
HK
VTS
ID
K
A
N
V
L
QS
S
I-L
W
R
E
I
V
NE
IA
T
EY
--------------------
P
DV
ELAHMY
ID
NATM
Q
L
I
KD
P
S
QFDV
L
L
CSNLFGDILSD
EC
A
M
I
TG
S
M
G
ML
PSA
S
LN
-
E
QG
F
-
G
L
Y
EP
A
G
GSAPDIAGKNIANPIA
Q
ILS
L
A
LL
LR
Y
S
L
DA
D
D
-
---
AA
CA
I
ER
AI
N
R
A
L
EE
G
IR
T
G
D
LA
R
---
GAA
AVS
T
D
E
M
GD
I
I
A
R
YVAEGV
fig|749544.3.peg.1709
Escherichia coli MS 175-1
MSKN
YH
IA
V
L
PGDGIG
P
EV
M
T
QA
LKVLDA
V
R
N
R
F
---
AMR
I
T
TSHYDV
G
GAA
-
IDN
HGQ
P
--
LP
PA
T
V
E
GCE
Q
A
DA
VL
FG
S
VG
GPK
W
EHLP
PD
QQ
P
ER
G
A
L
----
L
P
LR
K
H
F
K
L
F
S
NLRP
AK
LYQG
L
EAF
CPL
R
A
D
I
A
A
NGF
D
ILC
VRE
L
T
G
GIY
F
GQPK
GR
EG
SG
-
Q
Y
EK
AF
DTE
V
Y
H
R
F
E
I
-----------------------
E
RI
A
R
I
AFE
S
A
RK
R
-
R
HK
VTS
ID
K
A
N
V
L
QS
S
I-L
W
R
E
I
V
NE
IA
T
EY
--------------------
P
DV
ELAHMY
ID
NATM
Q
L
I
KD
P
S
QFDV
L
L
CSNLFGDILSD
EC
A
M
I
TG
S
M
G
ML
PSA
S
LN
-
E
QG
F
-
G
L
Y
EP
A
G
GSAPDIAGKNIANPIA
Q
ILS
L
A
LL
LR
Y
S
L
DA
D
D
-
---
AA
CA
I
ER
AI
N
R
A
L
EE
G
IR
T
G
D
LA
R
---
GAA
AVS
T
D
E
M
GD
I
I
A
R
YVAEGV
fig|749545.3.peg.1310
Escherichia coli MS 182-1
MSKN
YH
IA
V
L
PGDGIG
P
EV
M
T
QA
LKVLDA
V
R
N
R
F
---
AMR
I
T
TSHYDV
G
GAA
-
IDN
HGQ
P
--
LP
PA
T
V
E
GCE
Q
A
DA
VL
FG
S
VG
GPK
W
EHLP
PD
QQ
P
ER
G
A
L
----
L
P
LR
K
H
F
K
L
F
S
NLRP
AK
LYQG
L
EAF
CPL
R
A
D
I
A
A
NGF
D
ILC
VRE
L
T
G
GIY
F
GQPK
GR
EG
SG
-
Q
Y
EK
AF
DTE
V
Y
H
R
F
E
I
-----------------------
E
RI
A
R
I
AFE
S
A
RK
R
-
R
HK
VTS
ID
K
A
N
V
L
QS
S
I-L
W
R
E
I
V
NE
IA
T
EY
--------------------
P
DV
ELAHMY
ID
NATM
Q
L
I
KD
P
S
QFDV
L
L
CSNLFGDILSD
EC
A
M
I
TG
S
M
G
ML
PSA
S
LN
-
E
QG
F
-
G
L
Y
EP
A
G
GSAPDIAGKNIANPIA
Q
ILS
L
A
LL
LR
Y
S
L
DA
D
D
-
---
AA
CA
I
ER
AI
N
R
A
L
EE
G
IR
T
G
D
LA
R
---
GAA
AVS
T
D
E
M
GD
I
I
A
R
YVAEGV
fig|749547.3.peg.3866
Escherichia coli MS 187-1
MSKN
YH
IA
V
L
PGDGIG
P
EV
M
T
QA
LKVLDA
V
R
N
R
F
---
AMR
I
T
TSHYDV
G
GAA
-
IDN
HGQ
P
--
LP
PA
T
V
E
GCE
Q
A
DA
VL
FG
S
VG
GPK
W
EHLP
PD
QQ
P
ER
G
A
L
----
L
P
LR
K
H
F
K
L
F
S
NLRP
AK
LYQG
L
EAF
CPL
R
A
D
I
A
A
NGF
D
ILC
VRE
L
T
G
GIY
F
GQPK
GR
EG
SG
-
Q
Y
EK
AF
DTE
V
Y
H
R
F
E
I
-----------------------
E
RI
A
R
I
AFE
S
A
RK
R
-
R
HK
VTS
ID
K
A
N
V
L
QS
S
I-L
W
R
E
I
V
NE
IA
T
EY
--------------------
P
DV
ELAHMY
ID
NATM
Q
L
I
KD
P
S
QFDV
L
L
CSNLFGDILSD
EC
A
M
I
TG
S
M
G
ML
PSA
S
LN
-
E
QG
F
-
G
L
Y
EP
A
G
GSAPDIAGKNIANPIA
Q
ILS
L
A
LL
LR
Y
S
L
DA
D
D
-
---
AA
CA
I
ER
AI
N
R
A
L
EE
G
IR
T
G
D
LA
R
---
GAA
AVS
T
D
E
M
GD
I
I
A
R
YVAEGV
fig|749548.3.peg.4240
Escherichia coli MS 196-1
MSKN
YH
IA
V
L
PGDGIG
P
EV
M
T
QA
LKVLDA
V
R
N
R
F
---
AMR
I
T
TSHYDV
G
GAA
-
IDN
HGQ
P
--
LP
PA
T
V
E
GCE
Q
A
DA
VL
FG
S
VG
GPK
W
EHLP
PD
QQ
P
ER
G
A
L
----
L
P
LR
K
H
F
K
L
F
S
NLRP
AK
LYQG
L
EAF
CPL
R
A
D
I
A
A
NGF
D
ILC
VRE
L
T
G
GIY
F
GQPK
GR
EG
SG
-
Q
Y
EK
AF
DTE
V
Y
H
R
F
E
I
-----------------------
E
RI
A
R
I
AFE
S
A
RK
R
-
R
HK
VTS
ID
K
A
N
V
L
QS
S
I-L
W
R
E
I
V
NE
IA
T
EY
--------------------
P
DV
ELAHMY
ID
NATM
Q
L
I
KD
P
S
QFDV
L
L
CSNLFGDILSD
EC
A
M
I
TG
S
M
G
ML
PSA
S
LN
-
E
QG
F
-
G
L
Y
EP
A
G
GSAPDIAGKNIANPIA
Q
ILS
L
A
LL
LR
Y
S
L
DA
D
D
-
---
AA
CA
I
ER
AI
N
R
A
L
EE
G
IR
T
G
D
LA
R
---
GAA
AVS
T
D
E
M
GD
I
I
A
R
YVAEGV
fig|749532.3.peg.4193
Escherichia coli MS 78-1
MSKN
YH
IA
V
L
PGDGIG
P
EV
M
T
QA
LKVLDA
V
R
N
R
F
---
AMR
I
T
TSHYDV
G
GAA
-
IDN
HGQ
P
--
LP
PA
T
V
E
GCE
Q
A
DA
VL
FG
S
VG
GPK
W
EHLP
PD
QQ
P
ER
G
A
L
----
L
P
LR
K
H
F
K
L
F
S
NLRP
AK
LYQG
L
EAF
CPL
R
A
D
I
A
A
NGF
D
ILC
VRE
L
T
G
GIY
F
GQPK
GR
EG
SG
-
Q
Y
EK
AF
DTE
V
Y
H
R
F
E
I
-----------------------
E
RI
A
R
I
AFE
S
A
RK
R
-
R
HK
VTS
ID
K
A
N
V
L
QS
S
I-L
W
R
E
I
V
NE
IA
T
EY
--------------------
P
DV
ELAHMY
ID
NATM
Q
L
I
KD
P
S
QFDV
L
L
CSNLFGDILSD
EC
A
M
I
TG
S
M
G
ML
PSA
S
LN
-
E
QG
F
-
G
L
Y
EP
A
G
GSAPDIAGKNIANPIA
Q
ILS
L
A
LL
LR
Y
S
L
DA
D
D
-
---
AA
CA
I
ER
AI
N
R
A
L
EE
G
IR
T
G
D
LA
R
---
GAA
AVS
T
D
E
M
GD
I
I
A
R
YVAEGV
fig|749533.3.peg.3356
Escherichia coli MS 84-1
MSKN
YH
IA
V
L
PGDGIG
P
EV
M
T
QA
LKVLDA
V
R
N
R
F
---
AMR
I
T
TSHYDV
G
GAA
-
IDN
HGQ
P
--
LP
PA
T
V
E
GCE
Q
A
DA
VL
FG
S
VG
GPK
W
EHLP
PD
QQ
P
ER
G
A
L
----
L
P
LR
K
H
F
K
L
F
S
NLRP
AK
LYQG
L
EAF
CPL
R
A
D
I
A
A
NGF
D
ILC
VRE
L
T
G
GIY
F
GQPK
GR
EG
SG
-
Q
Y
EK
AF
DTE
V
Y
H
R
F
E
I
-----------------------
E
RI
A
R
I
AFE
S
A
RK
R
-
R
HK
VTS
ID
K
A
N
V
L
QS
S
I-L
W
R
E
I
V
NE
IA
T
EY
--------------------
P
DV
ELAHMY
ID
NATM
Q
L
I
KD
P
S
QFDV
L
L
CSNLFGDILSD
EC
A
M
I
TG
S
M
G
ML
PSA
S
LN
-
E
QG
F
-
G
L
Y
EP
A
G
GSAPDIAGKNIANPIA
Q
ILS
L
A
LL
LR
Y
S
L
DA
D
D
-
---
AA
CA
I
ER
AI
N
R
A
L
EE
G
IR
T
G
D
LA
R
---
GAA
AVS
T
D
E
M
GD
I
I
A
R
YVAEGV
fig|585395.4.peg.75
Escherichia coli O103:H2 str. 12009
MSKN
YH
IA
V
L
PGDGIG
P
EV
M
T
QA
LKVLDA
V
R
N
R
F
---
AMR
I
T
TSHYDV
G
GAA
-
IDN
HGQ
P
--
LP
PA
T
V
E
GCE
Q
A
DA
VL
FG
S
VG
GPK
W
EHLP
PD
QQ
P
ER
G
A
L
----
L
P
LR
K
H
F
K
L
F
S
NLRP
AK
LYQG
L
EAF
CPL
R
A
D
I
A
A
NGF
D
ILC
VRE
L
T
G
GIY
F
GQPK
GR
EG
SG
-
Q
Y
EK
AF
DTE
V
Y
H
R
F
E
I
-----------------------
E
RI
A
R
I
AFE
S
A
RK
R
-
R
HK
VTS
ID
K
A
N
V
L
QS
S
I-L
W
R
E
I
V
NE
IA
T
EY
--------------------
P
DV
ELAHMY
ID
NATM
Q
L
I
KD
P
S
QFDV
L
L
CSNLFGDILSD
EC
A
M
I
TG
S
M
G
ML
PSA
S
LN
-
E
QG
F
-
G
L
Y
EP
A
G
GSAPDIAGKNIANPIA
Q
ILS
L
A
LL
LR
Y
S
L
DA
D
D
-
---
AA
CA
I
ER
AI
N
R
A
L
EE
G
IR
T
G
D
LA
R
---
GAA
AVS
T
D
E
M
GD
I
I
A
R
YVAEGV
fig|585396.4.peg.76
Escherichia coli O111:H- str. 11128
MSKN
YH
IA
V
L
PGDGIG
P
EV
M
T
QA
LKVLDA
V
R
N
R
F
---
AMR
I
T
TSHYDV
G
GAA
-
IDN
HGQ
P
--
LP
PA
T
V
E
GCE
Q
A
DA
VL
FG
S
VG
GPK
W
EHLP
PD
QQ
P
ER
G
A
L
----
L
P
LR
K
H
F
K
L
F
S
NLRP
AK
LYQG
L
EAF
CPL
R
A
D
I
A
A
NGF
D
ILC
VRE
L
T
G
GIY
F
GQPK
GR
EG
SG
-
Q
Y
EK
AF
DTE
V
Y
H
R
F
E
I
-----------------------
E
RI
A
R
I
AFE
S
A
RK
R
-
R
HK
VTS
ID
K
A
N
V
L
QS
S
I-L
W
R
E
I
V
NE
IA
T
EY
--------------------
P
DV
ELAHMY
ID
NATM
Q
L
I
KD
P
S
QFDV
L
L
CSNLFGDILSD
EC
A
M
I
TG
S
M
G
ML
PSA
S
LN
-
E
QG
F
-
G
L
Y
EP
A
G
GSAPDIAGKNIANPIA
Q
ILS
L
A
LL
LR
Y
S
L
DA
D
D
-
---
AA
CA
I
ER
AI
N
R
A
L
EE
G
IR
T
G
D
LA
R
---
GAA
AVS
T
D
E
M
GD
I
I
A
R
YVAEGV
fig|573235.3.peg.77
Escherichia coli O26:H11 str. 11368
MSKN
YH
IA
V
L
PGDGIG
P
EV
M
T
QA
LKVLDA
V
R
N
R
F
---
AMR
I
T
TSHYDV
G
GAA
-
IDN
HGQ
P
--
LP
PA
T
V
E
GCE
Q
A
DA
VL
FG
S
VG
GPK
W
EHLP
PD
QQ
P
ER
G
A
L
----
L
P
LR
K
H
F
K
L
F
S
NLRP
AK
LYQG
L
EAF
CPL
R
A
D
I
A
A
NGF
D
ILC
VRE
L
T
G
GIY
F
GQPK
GR
EG
SG
-
Q
Y
EK
AF
DTE
V
Y
H
R
F
E
I
-----------------------
E
RI
A
R
I
AFE
S
A
RK
R
-
R
HK
VTS
ID
K
A
N
V
L
QS
S
I-L
W
R
E
I
V
NE
IA
T
EY
--------------------
P
DV
ELAHMY
ID
NATM
Q
L
I
KD
P
S
QFDV
L
L
CSNLFGDILSD
EC
A
M
I
TG
S
M
G
ML
PSA
S
LN
-
E
QG
F
-
G
L
Y
EP
A
G
GSAPDIAGKNIANPIA
Q
ILS
L
A
LL
LR
Y
S
L
DA
D
D
-
---
AA
CA
I
ER
AI
N
R
A
L
EE
G
IR
T
G
D
LA
R
---
GAA
AVS
T
D
E
M
GD
I
I
A
R
YVAEGV
fig|637912.3.peg.507
Escherichia coli OP50
MSKN
YH
IA
V
L
PGDGIG
P
EV
M
T
QA
LKVLDA
V
R
N
R
F
---
AMR
I
T
TSHYDV
G
GAA
-
IDN
HGQ
P
--
LP
PA
T
V
E
GCE
Q
A
DA
VL
FG
S
VG
GPK
W
EHLP
PD
QQ
P
ER
G
A
L
----
L
P
LR
K
H
F
K
L
F
S
NLRP
AK
LYQG
L
EAF
CPL
R
A
D
I
A
A
NGF
D
ILC
VRE
L
T
G
GIY
F
GQPK
GR
EG
SG
-
Q
Y
EK
AF
DTE
V
Y
H
R
F
E
I
-----------------------
E
RI
A
R
I
AFE
S
A
RK
R
-
R
HK
VTS
ID
K
A
N
V
L
QS
S
I-L
W
R
E
I
V
NE
IA
T
EY
--------------------
P
DV
ELAHMY
ID
NATM
Q
L
I
KD
P
S
QFDV
L
L
CSNLFGDILSD
EC
A
M
I
TG
S
M
G
ML
PSA
S
LN
-
E
QG
F
-
G
L
Y
EP
A
G
GSAPDIAGKNIANPIA
Q
ILS
L
A
LL
LR
Y
S
L
DA
D
D
-
---
AA
CA
I
ER
AI
N
R
A
L
EE
G
IR
T
G
D
LA
R
---
GAA
AVS
T
D
E
M
GD
I
I
A
R
YVAEGV
fig|409438.11.peg.192
Escherichia coli SE11
MSKN
YH
IA
V
L
PGDGIG
P
EV
M
T
QA
LKVLDA
V
R
N
R
F
---
AMR
I
T
TSHYDV
G
GAA
-
IDN
HGQ
P
--
LP
PA
T
V
E
GCE
Q
A
DA
VL
FG
S
VG
GPK
W
EHLP
PD
QQ
P
ER
G
A
L
----
L
P
LR
K
H
F
K
L
F
S
NLRP
AK
LYQG
L
EAF
CPL
R
A
D
I
A
A
NGF
D
ILC
VRE
L
T
G
GIY
F
GQPK
GR
EG
SG
-
Q
Y
EK
AF
DTE
V
Y
H
R
F
E
I
-----------------------
E
RI
A
R
I
AFE
S
A
RK
R
-
R
HK
VTS
ID
K
A
N
V
L
QS
S
I-L
W
R
E
I
V
NE
IA
T
EY
--------------------
P
DV
ELAHMY
ID
NATM
Q
L
I
KD
P
S
QFDV
L
L
CSNLFGDILSD
EC
A
M
I
TG
S
M
G
ML
PSA
S
LN
-
E
QG
F
-
G
L
Y
EP
A
G
GSAPDIAGKNIANPIA
Q
ILS
L
A
LL
LR
Y
S
L
DA
D
D
-
---
AA
CA
I
ER
AI
N
R
A
L
EE
G
IR
T
G
D
LA
R
---
GAA
AVS
T
D
E
M
GD
I
I
A
R
YVAEGV
fig|656443.3.peg.202
Escherichia coli TA271
MSKN
YH
IA
V
L
PGDGIG
P
EV
M
T
QA
LKVLDA
V
R
N
R
F
---
AMR
I
T
TSHYDV
G
GAA
-
IDN
HGQ
P
--
LP
PA
T
V
E
GCE
Q
A
DA
VL
FG
S
VG
GPK
W
EHLP
PD
QQ
P
ER
G
A
L
----
L
P
LR
K
H
F
K
L
F
S
NLRP
AK
LYQG
L
EAF
CPL
R
A
D
I
A
A
NGF
D
ILC
VRE
L
T
G
GIY
F
GQPK
GR
EG
SG
-
Q
Y
EK
AF
DTE
V
Y
H
R
F
E
I
-----------------------
E
RI
A
R
I
AFE
S
A
RK
R
-
R
HK
VTS
ID
K
A
N
V
L
QS
S
I-L
W
R
E
I
V
NE
IA
T
EY
--------------------
P
DV
ELAHMY
ID
NATM
Q
L
I
KD
P
S
QFDV
L
L
CSNLFGDILSD
EC
A
M
I
TG
S
M
G
ML
PSA
S
LN
-
E
QG
F
-
G
L
Y
EP
A
G
GSAPDIAGKNIANPIA
Q
ILS
L
A
LL
LR
Y
S
L
DA
D
D
-
---
AA
CA
I
ER
AI
N
R
A
L
EE
G
IR
T
G
D
LA
R
---
GAA
AVS
T
D
E
M
GD
I
I
A
R
YVAEGV
fig|316407.3.peg.73
Escherichia coli W3110
MSKN
YH
IA
V
L
PGDGIG
P
EV
M
T
QA
LKVLDA
V
R
N
R
F
---
AMR
I
T
TSHYDV
G
GAA
-
IDN
HGQ
P
--
LP
PA
T
V
E
GCE
Q
A
DA
VL
FG
S
VG
GPK
W
EHLP
PD
QQ
P
ER
G
A
L
----
L
P
LR
K
H
F
K
L
F
S
NLRP
AK
LYQG
L
EAF
CPL
R
A
D
I
A
A
NGF
D
ILC
VRE
L
T
G
GIY
F
GQPK
GR
EG
SG
-
Q
Y
EK
AF
DTE
V
Y
H
R
F
E
I
-----------------------
E
RI
A
R
I
AFE
S
A
RK
R
-
R
HK
VTS
ID
K
A
N
V
L
QS
S
I-L
W
R
E
I
V
NE
IA
T
EY
--------------------
P
DV
ELAHMY
ID
NATM
Q
L
I
KD
P
S
QFDV
L
L
CSNLFGDILSD
EC
A
M
I
TG
S
M
G
ML
PSA
S
LN
-
E
QG
F
-
G
L
Y
EP
A
G
GSAPDIAGKNIANPIA
Q
ILS
L
A
LL
LR
Y
S
L
DA
D
D
-
---
AA
CA
I
ER
AI
N
R
A
L
EE
G
IR
T
G
D
LA
R
---
GAA
AVS
T
D
E
M
GD
I
I
A
R
YVAEGV
fig|511145.12.peg.76
Escherichia coli str. K-12 substr. MG1655
MSKN
YH
IA
V
L
PGDGIG
P
EV
M
T
QA
LKVLDA
V
R
N
R
F
---
AMR
I
T
TSHYDV
G
GAA
-
IDN
HGQ
P
--
LP
PA
T
V
E
GCE
Q
A
DA
VL
FG
S
VG
GPK
W
EHLP
PD
QQ
P
ER
G
A
L
----
L
P
LR
K
H
F
K
L
F
S
NLRP
AK
LYQG
L
EAF
CPL
R
A
D
I
A
A
NGF
D
ILC
VRE
L
T
G
GIY
F
GQPK
GR
EG
SG
-
Q
Y
EK
AF
DTE
V
Y
H
R
F
E
I
-----------------------
E
RI
A
R
I
AFE
S
A
RK
R
-
R
HK
VTS
ID
K
A
N
V
L
QS
S
I-L
W
R
E
I
V
NE
IA
T
EY
--------------------
P
DV
ELAHMY
ID
NATM
Q
L
I
KD
P
S
QFDV
L
L
CSNLFGDILSD
EC
A
M
I
TG
S
M
G
ML
PSA
S
LN
-
E
QG
F
-
G
L
Y
EP
A
G
GSAPDIAGKNIANPIA
Q
ILS
L
A
LL
LR
Y
S
L
DA
D
D
-
---
AA
CA
I
ER
AI
N
R
A
L
EE
G
IR
T
G
D
LA
R
---
GAA
AVS
T
D
E
M
GD
I
I
A
R
YVAEGV
fig|511145.6.peg.77
Escherichia coli str. K-12 substr. MG1655
MSKN
YH
IA
V
L
PGDGIG
P
EV
M
T
QA
LKVLDA
V
R
N
R
F
---
AMR
I
T
TSHYDV
G
GAA
-
IDN
HGQ
P
--
LP
PA
T
V
E
GCE
Q
A
DA
VL
FG
S
VG
GPK
W
EHLP
PD
QQ
P
ER
G
A
L
----
L
P
LR
K
H
F
K
L
F
S
NLRP
AK
LYQG
L
EAF
CPL
R
A
D
I
A
A
NGF
D
ILC
VRE
L
T
G
GIY
F
GQPK
GR
EG
SG
-
Q
Y
EK
AF
DTE
V
Y
H
R
F
E
I
-----------------------
E
RI
A
R
I
AFE
S
A
RK
R
-
R
HK
VTS
ID
K
A
N
V
L
QS
S
I-L
W
R
E
I
V
NE
IA
T
EY
--------------------
P
DV
ELAHMY
ID
NATM
Q
L
I
KD
P
S
QFDV
L
L
CSNLFGDILSD
EC
A
M
I
TG
S
M
G
ML
PSA
S
LN
-
E
QG
F
-
G
L
Y
EP
A
G
GSAPDIAGKNIANPIA
Q
ILS
L
A
LL
LR
Y
S
L
DA
D
D
-
---
AA
CA
I
ER
AI
N
R
A
L
EE
G
IR
T
G
D
LA
R
---
GAA
AVS
T
D
E
M
GD
I
I
A
R
YVAEGV
fig|595495.4.peg.1653
Escherichia coli KO11
MSKN
YH
IA
V
L
PGDGIG
P
EV
M
T
QA
LKVLDA
V
R
N
R
F
---
AMR
I
T
TSHYDV
G
GAA
-
IDN
HGQ
P
--
LP
PA
T
V
E
GCE
Q
A
DA
VL
FG
S
VG
GPK
W
EHLP
PD
QQ
P
ER
G
A
L
----
L
P
LR
K
H
F
K
L
F
S
NLRP
AK
LYQG
L
EAF
CPL
R
A
D
I
A
A
NGF
D
ILC
VRE
L
T
G
GIY
F
GQPK
GR
EG
SG
-
Q
Y
EK
AF
DTE
L
Y
H
R
F
E
I
-----------------------
E
RI
A
R
I
AFE
S
A
RK
R
-
R
HK
VTS
ID
K
A
N
V
L
QS
S
I-L
W
R
E
I
V
NE
IA
T
EY
--------------------
P
DV
ELAHMY
ID
NATM
Q
L
I
KD
P
S
QFDV
L
L
CSNLFGDILSD
EC
A
M
I
TG
S
M
G
ML
PSA
S
LN
-
E
QG
F
-
G
L
Y
EP
A
G
GSAPDIAGKNIANPIA
Q
ILS
L
A
LL
LR
Y
S
L
DA
D
D
-
---
AA
CA
I
ER
AI
N
R
A
L
EE
G
IR
T
G
D
LA
R
---
GAA
AVS
T
D
E
M
GD
I
I
A
R
YVAEGV
fig|566546.3.peg.1660
Escherichia coli W
MSKN
YH
IA
V
L
PGDGIG
P
EV
M
T
QA
LKVLDA
V
R
N
R
F
---
AMR
I
T
TSHYDV
G
GAA
-
IDN
HGQ
P
--
LP
PA
T
V
E
GCE
Q
A
DA
VL
FG
S
VG
GPK
W
EHLP
PD
QQ
P
ER
G
A
L
----
L
P
LR
K
H
F
K
L
F
S
NLRP
AK
LYQG
L
EAF
CPL
R
A
D
I
A
A
NGF
D
ILC
VRE
L
T
G
GIY
F
GQPK
GR
EG
SG
-
Q
Y
EK
AF
DTE
L
Y
H
R
F
E
I
-----------------------
E
RI
A
R
I
AFE
S
A
RK
R
-
R
HK
VTS
ID
K
A
N
V
L
QS
S
I-L
W
R
E
I
V
NE
IA
T
EY
--------------------
P
DV
ELAHMY
ID
NATM
Q
L
I
KD
P
S
QFDV
L
L
CSNLFGDILSD
EC
A
M
I
TG
S
M
G
ML
PSA
S
LN
-
E
QG
F
-
G
L
Y
EP
A
G
GSAPDIAGKNIANPIA
Q
ILS
L
A
LL
LR
Y
S
L
DA
D
D
-
---
AA
CA
I
ER
AI
N
R
A
L
EE
G
IR
T
G
D
LA
R
---
GAA
AVS
T
D
E
M
GD
I
I
A
R
YVAEGV
fig|566546.4.peg.71
Escherichia coli W
MSKN
YH
IA
V
L
PGDGIG
P
EV
M
T
QA
LKVLDA
V
R
N
R
F
---
AMR
I
T
TSHYDV
G
GAA
-
IDN
HGQ
P
--
LP
PA
T
V
E
GCE
Q
A
DA
VL
FG
S
VG
GPK
W
EHLP
PD
QQ
P
ER
G
A
L
----
L
P
LR
K
H
F
K
L
F
S
NLRP
AK
LYQG
L
EAF
CPL
R
A
D
I
A
A
NGF
D
ILC
VRE
L
T
G
GIY
F
GQPK
GR
EG
SG
-
Q
Y
EK
AF
DTE
L
Y
H
R
F
E
I
-----------------------
E
RI
A
R
I
AFE
S
A
RK
R
-
R
HK
VTS
ID
K
A
N
V
L
QS
S
I-L
W
R
E
I
V
NE
IA
T
EY
--------------------
P
DV
ELAHMY
ID
NATM
Q
L
I
KD
P
S
QFDV
L
L
CSNLFGDILSD
EC
A
M
I
TG
S
M
G
ML
PSA
S
LN
-
E
QG
F
-
G
L
Y
EP
A
G
GSAPDIAGKNIANPIA
Q
ILS
L
A
LL
LR
Y
S
L
DA
D
D
-
---
AA
CA
I
ER
AI
N
R
A
L
EE
G
IR
T
G
D
LA
R
---
GAA
AVS
T
D
E
M
GD
I
I
A
R
YVAEGV
fig|679204.3.peg.3188
Escherichia coli MS 145-7
MSKN
YH
IA
V
L
PGDGIG
P
EV
M
T
QA
LKVLDA
V
R
N
R
F
---
AMR
I
T
TSHYDV
G
GAA
-
IDN
HGQ
P
--
LP
PA
T
V
E
GCE
Q
A
DA
VL
FG
S
VG
GPK
W
EHLP
PD
QQ
P
ER
G
A
L
----
L
P
LR
K
HLK
L
F
S
NLRP
AK
LYQG
L
EAF
CPL
R
A
D
I
A
A
NGF
D
ILC
VRE
L
T
G
GIY
F
GQPK
GR
EG
SG
-
Q
Y
EK
AF
DTE
V
Y
H
R
F
E
I
-----------------------
E
RI
A
R
I
AFE
S
A
RK
R
-
R
HK
VTS
ID
K
A
N
V
L
QS
S
I-L
W
R
E
I
V
NE
IA
T
EY
--------------------
P
DV
ELAHMY
ID
NATM
Q
L
I
KD
P
S
QFDV
L
L
CSNLFGDILSD
EC
A
M
I
TG
S
M
G
ML
PSA
S
LN
-
E
QG
F
-
G
L
Y
EP
A
G
GSAPDIAGKNIANPIA
Q
ILS
L
A
LL
LR
Y
S
L
DA
D
D
-
---
AA
CA
I
ER
AI
N
R
A
L
EE
G
IR
T
G
D
LA
R
---
GAA
AVS
T
D
E
M
GD
I
I
A
R
YVAEGV
fig|670897.3.peg.1893
Escherichia coli 2362-75
MSKN
YH
IA
V
L
PGDGIG
P
EV
M
T
QA
LKVLDA
V
R
N
R
F
---
AMR
I
T
TSHYDV
G
GAA
-
IDN
HGQ
P
--
LP
PA
T
V
E
GCE
Q
A
DA
VL
FG
S
VG
GPK
W
EHLP
PD
QQ
P
ER
G
A
L
----
L
P
LR
K
H
F
K
L
F
S
NLRP
AK
LYQG
L
EAF
CPL
R
A
D
I
A
A
NGF
D
ILC
VRE
L
T
G
GIY
F
GQPK
GR
EG
SG
-
Q
Y
EK
AF
DTE
V
Y
H
R
F
E
I
-----------------------
E
RI
A
R
I
AFE
S
A
RK
R
-
R
HK
VTS
ID
K
A
N
V
L
QS
S
I-L
W
R
E
I
V
NE
IA
T
EY
--------------------
P
DV
ELAHMY
ID
NATM
Q
L
I
KD
P
S
QFDV
L
L
CSNLFGDILSD
EC
A
M
I
TG
S
M
G
ML
PSA
S
LN
-
E
QG
F
-
G
L
Y
EP
A
G
GSAPDIAGKNIANPIA
Q
ILS
L
A
LL
LR
Y
S
L
DA
D
D
-
---
AA
SA
I
ER
AI
N
R
A
L
EE
G
IR
T
G
D
LA
R
---
GAA
AVS
T
D
E
M
GD
I
I
A
R
YVAEGV
fig|405955.13.peg.82
Escherichia coli APEC O1
MSKN
YH
IA
V
L
PGDGIG
P
EV
M
T
QA
LKVLDA
V
R
N
R
F
---
AMR
I
T
TSHYDV
G
GAA
-
IDN
HGQ
P
--
LP
PA
T
V
E
GCE
Q
A
DA
VL
FG
S
VG
GPK
W
EHLP
PD
QQ
P
ER
G
A
L
----
L
P
LR
K
H
F
K
L
F
S
NLRP
AK
LYQG
L
EAF
CPL
R
A
D
I
A
A
NGF
D
ILC
VRE
L
T
G
GIY
F
GQPK
GR
EG
SG
-
Q
Y
EK
AF
DTE
V
Y
H
R
F
E
I
-----------------------
E
RI
A
R
I
AFE
S
A
RK
R
-
R
HK
VTS
ID
K
A
N
V
L
QS
S
I-L
W
R
E
I
V
NE
IA
T
EY
--------------------
P
DV
ELAHMY
ID
NATM
Q
L
I
KD
P
S
QFDV
L
L
CSNLFGDILSD
EC
A
M
I
TG
S
M
G
ML
PSA
S
LN
-
E
QG
F
-
G
L
Y
EP
A
G
GSAPDIAGKNIANPIA
Q
ILS
L
A
LL
LR
Y
S
L
DA
D
D
-
---
AA
SA
I
ER
AI
N
R
A
L
EE
G
IR
T
G
D
LA
R
---
GAA
AVS
T
D
E
M
GD
I
I
A
R
YVAEGV
fig|405955.9.peg.63
Escherichia coli APEC O1
MSKN
YH
IA
V
L
PGDGIG
P
EV
M
T
QA
LKVLDA
V
R
N
R
F
---
AMR
I
T
TSHYDV
G
GAA
-
IDN
HGQ
P
--
LP
PA
T
V
E
GCE
Q
A
DA
VL
FG
S
VG
GPK
W
EHLP
PD
QQ
P
ER
G
A
L
----
L
P
LR
K
H
F
K
L
F
S
NLRP
AK
LYQG
L
EAF
CPL
R
A
D
I
A
A
NGF
D
ILC
VRE
L
T
G
GIY
F
GQPK
GR
EG
SG
-
Q
Y
EK
AF
DTE
V
Y
H
R
F
E
I
-----------------------
E
RI
A
R
I
AFE
S
A
RK
R
-
R
HK
VTS
ID
K
A
N
V
L
QS
S
I-L
W
R
E
I
V
NE
IA
T
EY
--------------------
P
DV
ELAHMY
ID
NATM
Q
L
I
KD
P
S
QFDV
L
L
CSNLFGDILSD
EC
A
M
I
TG
S
M
G
ML
PSA
S
LN
-
E
QG
F
-
G
L
Y
EP
A
G
GSAPDIAGKNIANPIA
Q
ILS
L
A
LL
LR
Y
S
L
DA
D
D
-
---
AA
SA
I
ER
AI
N
R
A
L
EE
G
IR
T
G
D
LA
R
---
GAA
AVS
T
D
E
M
GD
I
I
A
R
YVAEGV
fig|550676.3.peg.4742
Escherichia coli B185
MSKN
YH
IA
V
L
PGDGIG
P
EV
M
T
QA
LKVLDA
V
R
N
R
F
---
AMR
I
T
TSHYDV
G
GAA
-
IDN
HGQ
P
--
LP
PA
T
V
E
GCE
Q
A
DA
VL
FG
S
VG
GPK
W
EHLP
PD
QQ
P
ER
G
A
L
----
L
P
LR
K
H
F
K
L
F
S
NLRP
AK
LYQG
L
EAF
CPL
R
A
D
I
A
A
NGF
D
ILC
VRE
L
T
G
GIY
F
GQPK
GR
EG
SG
-
Q
Y
EK
AF
DTE
V
Y
H
R
F
E
I
-----------------------
E
RI
A
R
I
AFE
S
A
RK
R
-
R
HK
VTS
ID
K
A
N
V
L
QS
S
I-L
W
R
E
I
V
NE
IA
T
EY
--------------------
P
DV
ELAHMY
ID
NATM
Q
L
I
KD
P
S
QFDV
L
L
CSNLFGDILSD
EC
A
M
I
TG
S
M
G
ML
PSA
S
LN
-
E
QG
F
-
G
L
Y
EP
A
G
GSAPDIAGKNIANPIA
Q
ILS
L
A
LL
LR
Y
S
L
DA
D
D
-
---
AA
SA
I
ER
AI
N
R
A
L
EE
G
IR
T
G
D
LA
R
---
GAA
AVS
T
D
E
M
GD
I
I
A
R
YVAEGV
fig|340186.3.peg.4042
Escherichia coli E110019
MSKN
YH
IA
V
L
PGDGIG
P
EV
M
T
QA
LKVLDA
V
R
N
R
F
---
AMR
I
T
TSHYDV
G
GAA
-
IDN
HGQ
P
--
LP
PA
T
V
E
GCE
Q
A
DA
VL
FG
S
VG
GPK
W
EHLP
PD
QQ
P
ER
G
A
L
----
L
P
LR
K
H
F
K
L
F
S
NLRP
AK
LYQG
L
EAF
CPL
R
A
D
I
A
A
NGF
D
ILC
VRE
L
T
G
GIY
F
GQPK
GR
EG
SG
-
Q
Y
EK
AF
DTE
V
Y
H
R
F
E
I
-----------------------
E
RI
A
R
I
AFE
S
A
RK
R
-
R
HK
VTS
ID
K
A
N
V
L
QS
S
I-L
W
R
E
I
V
NE
IA
T
EY
--------------------
P
DV
ELAHMY
ID
NATM
Q
L
I
KD
P
S
QFDV
L
L
CSNLFGDILSD
EC
A
M
I
TG
S
M
G
ML
PSA
S
LN
-
E
QG
F
-
G
L
Y
EP
A
G
GSAPDIAGKNIANPIA
Q
ILS
L
A
LL
LR
Y
S
L
DA
D
D
-
---
AA
SA
I
ER
AI
N
R
A
L
EE
G
IR
T
G
D
LA
R
---
GAA
AVS
T
D
E
M
GD
I
I
A
R
YVAEGV
fig|340186.5.peg.4250
Escherichia coli E110019
MSKN
YH
IA
V
L
PGDGIG
P
EV
M
T
QA
LKVLDA
V
R
N
R
F
---
AMR
I
T
TSHYDV
G
GAA
-
IDN
HGQ
P
--
LP
PA
T
V
E
GCE
Q
A
DA
VL
FG
S
VG
GPK
W
EHLP
PD
QQ
P
ER
G
A
L
----
L
P
LR
K
H
F
K
L
F
S
NLRP
AK
LYQG
L
EAF
CPL
R
A
D
I
A
A
NGF
D
ILC
VRE
L
T
G
GIY
F
GQPK
GR
EG
SG
-
Q
Y
EK
AF
DTE
V
Y
H
R
F
E
I
-----------------------
E
RI
A
R
I
AFE
S
A
RK
R
-
R
HK
VTS
ID
K
A
N
V
L
QS
S
I-L
W
R
E
I
V
NE
IA
T
EY
--------------------
P
DV
ELAHMY
ID
NATM
Q
L
I
KD
P
S
QFDV
L
L
CSNLFGDILSD
EC
A
M
I
TG
S
M
G
ML
PSA
S
LN
-
E
QG
F
-
G
L
Y
EP
A
G
GSAPDIAGKNIANPIA
Q
ILS
L
A
LL
LR
Y
S
L
DA
D
D
-
---
AA
SA
I
ER
AI
N
R
A
L
EE
G
IR
T
G
D
LA
R
---
GAA
AVS
T
D
E
M
GD
I
I
A
R
YVAEGV
fig|216593.1.peg.3499
Escherichia coli E2348/69 (2-364/364)
MSKN
YH
IA
V
L
PGDGIG
P
EV
M
T
QA
LKVLDA
V
R
N
R
F
---
AMR
I
T
TSHYDV
G
GAA
-
IDN
HGQ
P
--
LP
PA
T
V
E
GCE
Q
A
DA
VL
FG
S
VG
GPK
W
EHLP
PD
QQ
P
ER
G
A
L
----
L
P
LR
K
H
F
K
L
F
S
NLRP
AK
LYQG
L
EAF
CPL
R
A
D
I
A
A
NGF
D
ILC
VRE
L
T
G
GIY
F
GQPK
GR
EG
SG
-
Q
Y
EK
AF
DTE
V
Y
H
R
F
E
I
-----------------------
E
RI
A
R
I
AFE
S
A
RK
R
-
R
HK
VTS
ID
K
A
N
V
L
QS
S
I-L
W
R
E
I
V
NE
IA
T
EY
--------------------
P
DV
ELAHMY
ID
NATM
Q
L
I
KD
P
S
QFDV
L
L
CSNLFGDILSD
EC
A
M
I
TG
S
M
G
ML
PSA
S
LN
-
E
QG
F
-
G
L
Y
EP
A
G
GSAPDIAGKNIANPIA
Q
ILS
L
A
LL
LR
Y
S
L
DA
D
D
-
---
AA
SA
I
ER
AI
N
R
A
L
EE
G
IR
T
G
D
LA
R
---
GAA
AVS
T
D
E
M
GD
I
I
A
R
YVAEGV
fig|585397.7.peg.78
Escherichia coli ED1a
MSKN
YH
IA
V
L
PGDGIG
P
EV
M
T
QA
LKVLDA
V
R
N
R
F
---
AMR
I
T
TSHYDV
G
GAA
-
IDN
HGQ
P
--
LP
PA
T
V
E
GCE
Q
A
DA
VL
FG
S
VG
GPK
W
EHLP
PD
QQ
P
ER
G
A
L
----
L
P
LR
K
H
F
K
L
F
S
NLRP
AK
LYQG
L
EAF
CPL
R
A
D
I
A
A
NGF
D
ILC
VRE
L
T
G
GIY
F
GQPK
GR
EG
SG
-
Q
Y
EK
AF
DTE
V
Y
H
R
F
E
I
-----------------------
E
RI
A
R
I
AFE
S
A
RK
R
-
R
HK
VTS
ID
K
A
N
V
L
QS
S
I-L
W
R
E
I
V
NE
IA
T
EY
--------------------
P
DV
ELAHMY
ID
NATM
Q
L
I
KD
P
S
QFDV
L
L
CSNLFGDILSD
EC
A
M
I
TG
S
M
G
ML
PSA
S
LN
-
E
QG
F
-
G
L
Y
EP
A
G
GSAPDIAGKNIANPIA
Q
ILS
L
A
LL
LR
Y
S
L
DA
D
D
-
---
AA
SA
I
ER
AI
N
R
A
L
EE
G
IR
T
G
D
LA
R
---
GAA
AVS
T
D
E
M
GD
I
I
A
R
YVAEGV
fig|585397.9.peg.78
Escherichia coli ED1a
MSKN
YH
IA
V
L
PGDGIG
P
EV
M
T
QA
LKVLDA
V
R
N
R
F
---
AMR
I
T
TSHYDV
G
GAA
-
IDN
HGQ
P
--
LP
PA
T
V
E
GCE
Q
A
DA
VL
FG
S
VG
GPK
W
EHLP
PD
QQ
P
ER
G
A
L
----
L
P
LR
K
H
F
K
L
F
S
NLRP
AK
LYQG
L
EAF
CPL
R
A
D
I
A
A
NGF
D
ILC
VRE
L
T
G
GIY
F
GQPK
GR
EG
SG
-
Q
Y
EK
AF
DTE
V
Y
H
R
F
E
I
-----------------------
E
RI
A
R
I
AFE
S
A
RK
R
-
R
HK
VTS
ID
K
A
N
V
L
QS
S
I-L
W
R
E
I
V
NE
IA
T
EY
--------------------
P
DV
ELAHMY
ID
NATM
Q
L
I
KD
P
S
QFDV
L
L
CSNLFGDILSD
EC
A
M
I
TG
S
M
G
ML
PSA
S
LN
-
E
QG
F
-
G
L
Y
EP
A
G
GSAPDIAGKNIANPIA
Q
ILS
L
A
LL
LR
Y
S
L
DA
D
D
-
---
AA
SA
I
ER
AI
N
R
A
L
EE
G
IR
T
G
D
LA
R
---
GAA
AVS
T
D
E
M
GD
I
I
A
R
YVAEGV
fig|585057.4.peg.85
Escherichia coli IAI39
MSKN
YH
IA
V
L
PGDGIG
P
EV
M
T
QA
LKVLDA
V
R
N
R
F
---
AMR
I
T
TSHYDV
G
GAA
-
IDN
HGQ
P
--
LP
PA
T
V
E
GCE
Q
A
DA
VL
FG
S
VG
GPK
W
EHLP
PD
QQ
P
ER
G
A
L
----
L
P
LR
K
H
F
K
L
F
S
NLRP
AK
LYQG
L
EAF
CPL
R
A
D
I
A
A
NGF
D
ILC
VRE
L
T
G
GIY
F
GQPK
GR
EG
SG
-
Q
Y
EK
AF
DTE
V
Y
H
R
F
E
I
-----------------------
E
RI
A
R
I
AFE
S
A
RK
R
-
R
HK
VTS
ID
K
A
N
V
L
QS
S
I-L
W
R
E
I
V
NE
IA
T
EY
--------------------
P
DV
ELAHMY
ID
NATM
Q
L
I
KD
P
S
QFDV
L
L
CSNLFGDILSD
EC
A
M
I
TG
S
M
G
ML
PSA
S
LN
-
E
QG
F
-
G
L
Y
EP
A
G
GSAPDIAGKNIANPIA
Q
ILS
L
A
LL
LR
Y
S
L
DA
D
D
-
---
AA
SA
I
ER
AI
N
R
A
L
EE
G
IR
T
G
D
LA
R
---
GAA
AVS
T
D
E
M
GD
I
I
A
R
YVAEGV
fig|585057.6.peg.85
Escherichia coli IAI39
MSKN
YH
IA
V
L
PGDGIG
P
EV
M
T
QA
LKVLDA
V
R
N
R
F
---
AMR
I
T
TSHYDV
G
GAA
-
IDN
HGQ
P
--
LP
PA
T
V
E
GCE
Q
A
DA
VL
FG
S
VG
GPK
W
EHLP
PD
QQ
P
ER
G
A
L
----
L
P
LR
K
H
F
K
L
F
S
NLRP
AK
LYQG
L
EAF
CPL
R
A
D
I
A
A
NGF
D
ILC
VRE
L
T
G
GIY
F
GQPK
GR
EG
SG
-
Q
Y
EK
AF
DTE
V
Y
H
R
F
E
I
-----------------------
E
RI
A
R
I
AFE
S
A
RK
R
-
R
HK
VTS
ID
K
A
N
V
L
QS
S
I-L
W
R
E
I
V
NE
IA
T
EY
--------------------
P
DV
ELAHMY
ID
NATM
Q
L
I
KD
P
S
QFDV
L
L
CSNLFGDILSD
EC
A
M
I
TG
S
M
G
ML
PSA
S
LN
-
E
QG
F
-
G
L
Y
EP
A
G
GSAPDIAGKNIANPIA
Q
ILS
L
A
LL
LR
Y
S
L
DA
D
D
-
---
AA
SA
I
ER
AI
N
R
A
L
EE
G
IR
T
G
D
LA
R
---
GAA
AVS
T
D
E
M
GD
I
I
A
R
YVAEGV
fig|714962.3.peg.80
Escherichia coli IHE3034
MSKN
YH
IA
V
L
PGDGIG
P
EV
M
T
QA
LKVLDA
V
R
N
R
F
---
AMR
I
T
TSHYDV
G
GAA
-
IDN
HGQ
P
--
LP
PA
T
V
E
GCE
Q
A
DA
VL
FG
S
VG
GPK
W
EHLP
PD
QQ
P
ER
G
A
L
----
L
P
LR
K
H
F
K
L
F
S
NLRP
AK
LYQG
L
EAF
CPL
R
A
D
I
A
A
NGF
D
ILC
VRE
L
T
G
GIY
F
GQPK
GR
EG
SG
-
Q
Y
EK
AF
DTE
V
Y
H
R
F
E
I
-----------------------
E
RI
A
R
I
AFE
S
A
RK
R
-
R
HK
VTS
ID
K
A
N
V
L
QS
S
I-L
W
R
E
I
V
NE
IA
T
EY
--------------------
P
DV
ELAHMY
ID
NATM
Q
L
I
KD
P
S
QFDV
L
L
CSNLFGDILSD
EC
A
M
I
TG
S
M
G
ML
PSA
S
LN
-
E
QG
F
-
G
L
Y
EP
A
G
GSAPDIAGKNIANPIA
Q
ILS
L
A
LL
LR
Y
S
L
DA
D
D
-
---
AA
SA
I
ER
AI
N
R
A
L
EE
G
IR
T
G
D
LA
R
---
GAA
AVS
T
D
E
M
GD
I
I
A
R
YVAEGV
fig|749527.3.peg.3153
Escherichia coli MS 21-1
MSKN
YH
IA
V
L
PGDGIG
P
EV
M
T
QA
LKVLDA
V
R
N
R
F
---
AMR
I
T
TSHYDV
G
GAA
-
IDN
HGQ
P
--
LP
PA
T
V
E
GCE
Q
A
DA
VL
FG
S
VG
GPK
W
EHLP
PD
QQ
P
ER
G
A
L
----
L
P
LR
K
H
F
K
L
F
S
NLRP
AK
LYQG
L
EAF
CPL
R
A
D
I
A
A
NGF
D
ILC
VRE
L
T
G
GIY
F
GQPK
GR
EG
SG
-
Q
Y
EK
AF
DTE
V
Y
H
R
F
E
I
-----------------------
E
RI
A
R
I
AFE
S
A
RK
R
-
R
HK
VTS
ID
K
A
N
V
L
QS
S
I-L
W
R
E
I
V
NE
IA
T
EY
--------------------
P
DV
ELAHMY
ID
NATM
Q
L
I
KD
P
S
QFDV
L
L
CSNLFGDILSD
EC
A
M
I
TG
S
M
G
ML
PSA
S
LN
-
E
QG
F
-
G
L
Y
EP
A
G
GSAPDIAGKNIANPIA
Q
ILS
L
A
LL
LR
Y
S
L
DA
D
D
-
---
AA
SA
I
ER
AI
N
R
A
L
EE
G
IR
T
G
D
LA
R
---
GAA
AVS
T
D
E
M
GD
I
I
A
R
YVAEGV
fig|753642.3.peg.3560
Escherichia coli NC101
MSKN
YH
IA
V
L
PGDGIG
P
EV
M
T
QA
LKVLDA
V
R
N
R
F
---
AMR
I
T
TSHYDV
G
GAA
-
IDN
HGQ
P
--
LP
PA
T
V
E
GCE
Q
A
DA
VL
FG
S
VG
GPK
W
EHLP
PD
QQ
P
ER
G
A
L
----
L
P
LR
K
H
F
K
L
F
S
NLRP
AK
LYQG
L
EAF
CPL
R
A
D
I
A
A
NGF
D
ILC
VRE
L
T
G
GIY
F
GQPK
GR
EG
SG
-
Q
Y
EK
AF
DTE
V
Y
H
R
F
E
I
-----------------------
E
RI
A
R
I
AFE
S
A
RK
R
-
R
HK
VTS
ID
K
A
N
V
L
QS
S
I-L
W
R
E
I
V
NE
IA
T
EY
--------------------
P
DV
ELAHMY
ID
NATM
Q
L
I
KD
P
S
QFDV
L
L
CSNLFGDILSD
EC
A
M
I
TG
S
M
G
ML
PSA
S
LN
-
E
QG
F
-
G
L
Y
EP
A
G
GSAPDIAGKNIANPIA
Q
ILS
L
A
LL
LR
Y
S
L
DA
D
D
-
---
AA
SA
I
ER
AI
N
R
A
L
EE
G
IR
T
G
D
LA
R
---
GAA
AVS
T
D
E
M
GD
I
I
A
R
YVAEGV
fig|574521.7.peg.81
Escherichia coli O127:H6 str. E2348/69
MSKN
YH
IA
V
L
PGDGIG
P
EV
M
T
QA
LKVLDA
V
R
N
R
F
---
AMR
I
T
TSHYDV
G
GAA
-
IDN
HGQ
P
--
LP
PA
T
V
E
GCE
Q
A
DA
VL
FG
S
VG
GPK
W
EHLP
PD
QQ
P
ER
G
A
L
----
L
P
LR
K
H
F
K
L
F
S
NLRP
AK
LYQG
L
EAF
CPL
R
A
D
I
A
A
NGF
D
ILC
VRE
L
T
G
GIY
F
GQPK
GR
EG
SG
-
Q
Y
EK
AF
DTE
V
Y
H
R
F
E
I
-----------------------
E
RI
A
R
I
AFE
S
A
RK
R
-
R
HK
VTS
ID
K
A
N
V
L
QS
S
I-L
W
R
E
I
V
NE
IA
T
EY
--------------------
P
DV
ELAHMY
ID
NATM
Q
L
I
KD
P
S
QFDV
L
L
CSNLFGDILSD
EC
A
M
I
TG
S
M
G
ML
PSA
S
LN
-
E
QG
F
-
G
L
Y
EP
A
G
GSAPDIAGKNIANPIA
Q
ILS
L
A
LL
LR
Y
S
L
DA
D
D
-
---
AA
SA
I
ER
AI
N
R
A
L
EE
G
IR
T
G
D
LA
R
---
GAA
AVS
T
D
E
M
GD
I
I
A
R
YVAEGV
fig|585035.6.peg.84
Escherichia coli S88
MSKN
YH
IA
V
L
PGDGIG
P
EV
M
T
QA
LKVLDA
V
R
N
R
F
---
AMR
I
T
TSHYDV
G
GAA
-
IDN
HGQ
P
--
LP
PA
T
V
E
GCE
Q
A
DA
VL
FG
S
VG
GPK
W
EHLP
PD
QQ
P
ER
G
A
L
----
L
P
LR
K
H
F
K
L
F
S
NLRP
AK
LYQG
L
EAF
CPL
R
A
D
I
A
A
NGF
D
ILC
VRE
L
T
G
GIY
F
GQPK
GR
EG
SG
-
Q
Y
EK
AF
DTE
V
Y
H
R
F
E
I
-----------------------
E
RI
A
R
I
AFE
S
A
RK
R
-
R
HK
VTS
ID
K
A
N
V
L
QS
S
I-L
W
R
E
I
V
NE
IA
T
EY
--------------------
P
DV
ELAHMY
ID
NATM
Q
L
I
KD
P
S
QFDV
L
L
CSNLFGDILSD
EC
A
M
I
TG
S
M
G
ML
PSA
S
LN
-
E
QG
F
-
G
L
Y
EP
A
G
GSAPDIAGKNIANPIA
Q
ILS
L
A
LL
LR
Y
S
L
DA
D
D
-
---
AA
SA
I
ER
AI
N
R
A
L
EE
G
IR
T
G
D
LA
R
---
GAA
AVS
T
D
E
M
GD
I
I
A
R
YVAEGV
fig|431946.3.peg.83
Escherichia coli SE15
MSKN
YH
IA
V
L
PGDGIG
P
EV
M
T
QA
LKVLDA
V
R
N
R
F
---
AMR
I
T
TSHYDV
G
GAA
-
IDN
HGQ
P
--
LP
PA
T
V
E
GCE
Q
A
DA
VL
FG
S
VG
GPK
W
EHLP
PD
QQ
P
ER
G
A
L
----
L
P
LR
K
H
F
K
L
F
S
NLRP
AK
LYQG
L
EAF
CPL
R
A
D
I
A
A
NGF
D
ILC
VRE
L
T
G
GIY
F
GQPK
GR
EG
SG
-
Q
Y
EK
AF
DTE
V
Y
H
R
F
E
I
-----------------------
E
RI
A
R
I
AFE
S
A
RK
R
-
R
HK
VTS
ID
K
A
N
V
L
QS
S
I-L
W
R
E
I
V
NE
IA
T
EY
--------------------
P
DV
ELAHMY
ID
NATM
Q
L
I
KD
P
S
QFDV
L
L
CSNLFGDILSD
EC
A
M
I
TG
S
M
G
ML
PSA
S
LN
-
E
QG
F
-
G
L
Y
EP
A
G
GSAPDIAGKNIANPIA
Q
ILS
L
A
LL
LR
Y
S
L
DA
D
D
-
---
AA
SA
I
ER
AI
N
R
A
L
EE
G
IR
T
G
D
LA
R
---
GAA
AVS
T
D
E
M
GD
I
I
A
R
YVAEGV
fig|656440.3.peg.5132
Escherichia coli TA206
MSKN
YH
IA
V
L
PGDGIG
P
EV
M
T
QA
LKVLDA
V
R
N
R
F
---
AMR
I
T
TSHYDV
G
GAA
-
IDN
HGQ
P
--
LP
PA
T
V
E
GCE
Q
A
DA
VL
FG
S
VG
GPK
W
EHLP
PD
QQ
P
ER
G
A
L
----
L
P
LR
K
H
F
K
L
F
S
NLRP
AK
LYQG
L
EAF
CPL
R
A
D
I
A
A
NGF
D
ILC
VRE
L
T
G
GIY
F
GQPK
GR
EG
SG
-
Q
Y
EK
AF
DTE
V
Y
H
R
F
E
I
-----------------------
E
RI
A
R
I
AFE
S
A
RK
R
-
R
HK
VTS
ID
K
A
N
V
L
QS
S
I-L
W
R
E
I
V
NE
IA
T
EY
--------------------
P
DV
ELAHMY
ID
NATM
Q
L
I
KD
P
S
QFDV
L
L
CSNLFGDILSD
EC
A
M
I
TG
S
M
G
ML
PSA
S
LN
-
E
QG
F
-
G
L
Y
EP
A
G
GSAPDIAGKNIANPIA
Q
ILS
L
A
LL
LR
Y
S
L
DA
D
D
-
---
AA
SA
I
ER
AI
N
R
A
L
EE
G
IR
T
G
D
LA
R
---
GAA
AVS
T
D
E
M
GD
I
I
A
R
YVAEGV
fig|869729.3.peg.4982
Escherichia coli UM146
MSKN
YH
IA
V
L
PGDGIG
P
EV
M
T
QA
LKVLDA
V
R
N
R
F
---
AMR
I
T
TSHYDV
G
GAA
-
IDN
HGQ
P
--
LP
PA
T
V
E
GCE
Q
A
DA
VL
FG
S
VG
GPK
W
EHLP
PD
QQ
P
ER
G
A
L
----
L
P
LR
K
H
F
K
L
F
S
NLRP
AK
LYQG
L
EAF
CPL
R
A
D
I
A
A
NGF
D
ILC
VRE
L
T
G
GIY
F
GQPK
GR
EG
SG
-
Q
Y
EK
AF
DTE
V
Y
H
R
F
E
I
-----------------------
E
RI
A
R
I
AFE
S
A
RK
R
-
R
HK
VTS
ID
K
A
N
V
L
QS
S
I-L
W
R
E
I
V
NE
IA
T
EY
--------------------
P
DV
ELAHMY
ID
NATM
Q
L
I
KD
P
S
QFDV
L
L
CSNLFGDILSD
EC
A
M
I
TG
S
M
G
ML
PSA
S
LN
-
E
QG
F
-
G
L
Y
EP
A
G
GSAPDIAGKNIANPIA
Q
ILS
L
A
LL
LR
Y
S
L
DA
D
D
-
---
AA
SA
I
ER
AI
N
R
A
L
EE
G
IR
T
G
D
LA
R
---
GAA
AVS
T
D
E
M
GD
I
I
A
R
YVAEGV
fig|364106.7.peg.213
Escherichia coli UTI89
MSKN
YH
IA
V
L
PGDGIG
P
EV
M
T
QA
LKVLDA
V
R
N
R
F
---
AMR
I
T
TSHYDV
G
GAA
-
IDN
HGQ
P
--
LP
PA
T
V
E
GCE
Q
A
DA
VL
FG
S
VG
GPK
W
EHLP
PD
QQ
P
ER
G
A
L
----
L
P
LR
K
H
F
K
L
F
S
NLRP
AK
LYQG
L
EAF
CPL
R
A
D
I
A
A
NGF
D
ILC
VRE
L
T
G
GIY
F
GQPK
GR
EG
SG
-
Q
Y
EK
AF
DTE
V
Y
H
R
F
E
I
-----------------------
E
RI
A
R
I
AFE
S
A
RK
R
-
R
HK
VTS
ID
K
A
N
V
L
QS
S
I-L
W
R
E
I
V
NE
IA
T
EY
--------------------
P
DV
ELAHMY
ID
NATM
Q
L
I
KD
P
S
QFDV
L
L
CSNLFGDILSD
EC
A
M
I
TG
S
M
G
ML
PSA
S
LN
-
E
QG
F
-
G
L
Y
EP
A
G
GSAPDIAGKNIANPIA
Q
ILS
L
A
LL
LR
Y
S
L
DA
D
D
-
---
AA
SA
I
ER
AI
N
R
A
L
EE
G
IR
T
G
D
LA
R
---
GAA
AVS
T
D
E
M
GD
I
I
A
R
YVAEGV
fig|364106.8.peg.212
Escherichia coli UTI89
MSKN
YH
IA
V
L
PGDGIG
P
EV
M
T
QA
LKVLDA
V
R
N
R
F
---
AMR
I
T
TSHYDV
G
GAA
-
IDN
HGQ
P
--
LP
PA
T
V
E
GCE
Q
A
DA
VL
FG
S
VG
GPK
W
EHLP
PD
QQ
P
ER
G
A
L
----
L
P
LR
K
H
F
K
L
F
S
NLRP
AK
LYQG
L
EAF
CPL
R
A
D
I
A
A
NGF
D
ILC
VRE
L
T
G
GIY
F
GQPK
GR
EG
SG
-
Q
Y
EK
AF
DTE
V
Y
H
R
F
E
I
-----------------------
E
RI
A
R
I
AFE
S
A
RK
R
-
R
HK
VTS
ID
K
A
N
V
L
QS
S
I-L
W
R
E
I
V
NE
IA
T
EY
--------------------
P
DV
ELAHMY
ID
NATM
Q
L
I
KD
P
S
QFDV
L
L
CSNLFGDILSD
EC
A
M
I
TG
S
M
G
ML
PSA
S
LN
-
E
QG
F
-
G
L
Y
EP
A
G
GSAPDIAGKNIANPIA
Q
ILS
L
A
LL
LR
Y
S
L
DA
D
D
-
---
AA
SA
I
ER
AI
N
R
A
L
EE
G
IR
T
G
D
LA
R
---
GAA
AVS
T
D
E
M
GD
I
I
A
R
YVAEGV
fig|562.371.peg.4010
Escherichia coli 1044A
MSKN
YH
IA
V
L
PGDGIG
P
EV
M
T
QA
LKVLDA
V
R
N
R
F
---
AMR
I
T
TSHYDV
G
GAA
-
IDN
HGQ
P
--
LP
PA
T
V
E
GCE
Q
A
DA
VL
FG
S
VG
GPK
W
EHLP
PD
QQ
P
ER
G
A
L
----
L
P
LR
K
H
F
K
L
F
S
NLRP
AK
LYQG
L
EAF
CPL
R
A
D
I
A
A
NGF
D
ILC
VRE
L
T
G
GIY
F
GQPK
GR
EG
SG
-
Q
Y
EK
AF
DTE
V
Y
H
R
F
E
I
-----------------------
E
RI
A
R
I
AFE
S
A
RK
R
-
R
HK
VTS
ID
K
A
N
V
L
QS
S
I-L
W
R
E
I
V
NE
IA
T
EY
--------------------
P
D
I
ELAHMY
ID
NATM
Q
L
I
KD
P
S
QFDV
L
L
CSNLFGDILSD
EC
A
M
I
TG
S
M
G
ML
PSA
S
LN
-
E
QG
F
-
G
L
Y
EP
A
G
GSAPDIAGKNIANPIA
Q
ILS
L
A
LL
LR
Y
S
L
DA
D
D
-
---
AA
SA
I
ER
AI
N
R
A
L
EE
G
IR
T
G
D
LA
R
---
GAA
AVS
T
D
E
M
GD
I
I
A
R
YVAEGV
fig|562.373.peg.2195
Escherichia coli 1125A
MSKN
YH
IA
V
L
PGDGIG
P
EV
M
T
QA
LKVLDA
V
R
N
R
F
---
AMR
I
T
TSHYDV
G
GAA
-
IDN
HGQ
P
--
LP
PA
T
V
E
GCE
Q
A
DA
VL
FG
S
VG
GPK
W
EHLP
PD
QQ
P
ER
G
A
L
----
L
P
LR
K
H
F
K
L
F
S
NLRP
AK
LYQG
L
EAF
CPL
R
A
D
I
A
A
NGF
D
ILC
VRE
L
T
G
GIY
F
GQPK
GR
EG
SG
-
Q
Y
EK
AF
DTE
V
Y
H
R
F
E
I
-----------------------
E
RI
A
R
I
AFE
S
A
RK
R
-
R
HK
VTS
ID
K
A
N
V
L
QS
S
I-L
W
R
E
I
V
NE
IA
T
EY
--------------------
P
D
I
ELAHMY
ID
NATM
Q
L
I
KD
P
S
QFDV
L
L
CSNLFGDILSD
EC
A
M
I
TG
S
M
G
ML
PSA
S
LN
-
E
QG
F
-
G
L
Y
EP
A
G
GSAPDIAGKNIANPIA
Q
ILS
L
A
LL
LR
Y
S
L
DA
D
D
-
---
AA
SA
I
ER
AI
N
R
A
L
EE
G
IR
T
G
D
LA
R
---
GAA
AVS
T
D
E
M
GD
I
I
A
R
YVAEGV
fig|562.372.peg.3046
Escherichia coli 1212A
MSKN
YH
IA
V
L
PGDGIG
P
EV
M
T
QA
LKVLDA
V
R
N
R
F
---
AMR
I
T
TSHYDV
G
GAA
-
IDN
HGQ
P
--
LP
PA
T
V
E
GCE
Q
A
DA
VL
FG
S
VG
GPK
W
EHLP
PD
QQ
P
ER
G
A
L
----
L
P
LR
K
H
F
K
L
F
S
NLRP
AK
LYQG
L
EAF
CPL
R
A
D
I
A
A
NGF
D
ILC
VRE
L
T
G
GIY
F
GQPK
GR
EG
SG
-
Q
Y
EK
AF
DTE
V
Y
H
R
F
E
I
-----------------------
E
RI
A
R
I
AFE
S
A
RK
R
-
R
HK
VTS
ID
K
A
N
V
L
QS
S
I-L
W
R
E
I
V
NE
IA
T
EY
--------------------
P
D
I
ELAHMY
ID
NATM
Q
L
I
KD
P
S
QFDV
L
L
CSNLFGDILSD
EC
A
M
I
TG
S
M
G
ML
PSA
S
LN
-
E
QG
F
-
G
L
Y
EP
A
G
GSAPDIAGKNIANPIA
Q
ILS
L
A
LL
LR
Y
S
L
DA
D
D
-
---
AA
SA
I
ER
AI
N
R
A
L
EE
G
IR
T
G
D
LA
R
---
GAA
AVS
T
D
E
M
GD
I
I
A
R
YVAEGV
fig|562.374.peg.2237
Escherichia coli 536A
MSKN
YH
IA
V
L
PGDGIG
P
EV
M
T
QA
LKVLDA
V
R
N
R
F
---
AMR
I
T
TSHYDV
G
GAA
-
IDN
HGQ
P
--
LP
PA
T
V
E
GCE
Q
A
DA
VL
FG
S
VG
GPK
W
EHLP
PD
QQ
P
ER
G
A
L
----
L
P
LR
K
H
F
K
L
F
S
NLRP
AK
LYQG
L
EAF
CPL
R
A
D
I
A
A
NGF
D
ILC
VRE
L
T
G
GIY
F
GQPK
GR
EG
SG
-
Q
Y
EK
AF
DTE
V
Y
H
R
F
E
I
-----------------------
E
RI
A
R
I
AFE
S
A
RK
R
-
R
HK
VTS
ID
K
A
N
V
L
QS
S
I-L
W
R
E
I
V
NE
IA
T
EY
--------------------
P
D
I
ELAHMY
ID
NATM
Q
L
I
KD
P
S
QFDV
L
L
CSNLFGDILSD
EC
A
M
I
TG
S
M
G
ML
PSA
S
LN
-
E
QG
F
-
G
L
Y
EP
A
G
GSAPDIAGKNIANPIA
Q
ILS
L
A
LL
LR
Y
S
L
DA
D
D
-
---
AA
SA
I
ER
AI
N
R
A
L
EE
G
IR
T
G
D
LA
R
---
GAA
AVS
T
D
E
M
GD
I
I
A
R
YVAEGV
fig|83334.1.peg.165
Escherichia coli O157:H7
MSKN
YH
IA
V
L
PGDGIG
P
EV
M
T
QA
LKVLDA
V
R
N
R
F
---
AMR
I
T
TSHYDV
G
GAA
-
IDN
HGQ
P
--
LP
PA
T
V
E
GCE
Q
A
DA
VL
FG
S
VG
GPK
W
EHLP
PD
QQ
P
ER
G
A
L
----
L
P
LR
K
H
F
K
L
F
S
NLRP
AK
LYQG
L
EAF
CPL
R
A
D
I
A
A
NGF
D
ILC
VRE
L
T
G
GIY
F
GQPK
GR
EG
SG
-
Q
Y
EK
AF
DTE
V
Y
H
R
F
E
I
-----------------------
E
RI
A
R
I
AFE
S
A
RK
R
-
R
HK
VTS
ID
K
A
N
V
L
QS
S
I-L
W
R
E
I
V
NE
IA
T
EY
--------------------
P
D
I
ELAHMY
ID
NATM
Q
L
I
KD
P
S
QFDV
L
L
CSNLFGDILSD
EC
A
M
I
TG
S
M
G
ML
PSA
S
LN
-
E
QG
F
-
G
L
Y
EP
A
G
GSAPDIAGKNIANPIA
Q
ILS
L
A
LL
LR
Y
S
L
DA
D
D
-
---
AA
SA
I
ER
AI
N
R
A
L
EE
G
IR
T
G
D
LA
R
---
GAA
AVS
T
D
E
M
GD
I
I
A
R
YVAEGV
fig|155864.1.peg.77
Escherichia coli O157:H7 EDL933 (2-364/364)
MSKN
YH
IA
V
L
PGDGIG
P
EV
M
T
QA
LKVLDA
V
R
N
R
F
---
AMR
I
T
TSHYDV
G
GAA
-
IDN
HGQ
P
--
LP
PA
T
V
E
GCE
Q
A
DA
VL
FG
S
VG
GPK
W
EHLP
PD
QQ
P
ER
G
A
L
----
L
P
LR
K
H
F
K
L
F
S
NLRP
AK
LYQG
L
EAF
CPL
R
A
D
I
A
A
NGF
D
ILC
VRE
L
T
G
GIY
F
GQPK
GR
EG
SG
-
Q
Y
EK
AF
DTE
V
Y
H
R
F
E
I
-----------------------
E
RI
A
R
I
AFE
S
A
RK
R
-
R
HK
VTS
ID
K
A
N
V
L
QS
S
I-L
W
R
E
I
V
NE
IA
T
EY
--------------------
P
D
I
ELAHMY
ID
NATM
Q
L
I
KD
P
S
QFDV
L
L
CSNLFGDILSD
EC
A
M
I
TG
S
M
G
ML
PSA
S
LN
-
E
QG
F
-
G
L
Y
EP
A
G
GSAPDIAGKNIANPIA
Q
ILS
L
A
LL
LR
Y
S
L
DA
D
D
-
---
AA
SA
I
ER
AI
N
R
A
L
EE
G
IR
T
G
D
LA
R
---
GAA
AVS
T
D
E
M
GD
I
I
A
R
YVAEGV
fig|155864.8.peg.78
Escherichia coli O157:H7 EDL933
MSKN
YH
IA
V
L
PGDGIG
P
EV
M
T
QA
LKVLDA
V
R
N
R
F
---
AMR
I
T
TSHYDV
G
GAA
-
IDN
HGQ
P
--
LP
PA
T
V
E
GCE
Q
A
DA
VL
FG
S
VG
GPK
W
EHLP
PD
QQ
P
ER
G
A
L
----
L
P
LR
K
H
F
K
L
F
S
NLRP
AK
LYQG
L
EAF
CPL
R
A
D
I
A
A
NGF
D
ILC
VRE
L
T
G
GIY
F
GQPK
GR
EG
SG
-
Q
Y
EK
AF
DTE
V
Y
H
R
F
E
I
-----------------------
E
RI
A
R
I
AFE
S
A
RK
R
-
R
HK
VTS
ID
K
A
N
V
L
QS
S
I-L
W
R
E
I
V
NE
IA
T
EY
--------------------
P
D
I
ELAHMY
ID
NATM
Q
L
I
KD
P
S
QFDV
L
L
CSNLFGDILSD
EC
A
M
I
TG
S
M
G
ML
PSA
S
LN
-
E
QG
F
-
G
L
Y
EP
A
G
GSAPDIAGKNIANPIA
Q
ILS
L
A
LL
LR
Y
S
L
DA
D
D
-
---
AA
SA
I
ER
AI
N
R
A
L
EE
G
IR
T
G
D
LA
R
---
GAA
AVS
T
D
E
M
GD
I
I
A
R
YVAEGV
fig|444454.5.peg.4541
Escherichia coli O157:H7 str. EC4024
MSKN
YH
IA
V
L
PGDGIG
P
EV
M
T
QA
LKVLDA
V
R
N
R
F
---
AMR
I
T
TSHYDV
G
GAA
-
IDN
HGQ
P
--
LP
PA
T
V
E
GCE
Q
A
DA
VL
FG
S
VG
GPK
W
EHLP
PD
QQ
P
ER
G
A
L
----
L
P
LR
K
H
F
K
L
F
S
NLRP
AK
LYQG
L
EAF
CPL
R
A
D
I
A
A
NGF
D
ILC
VRE
L
T
G
GIY
F
GQPK
GR
EG
SG
-
Q
Y
EK
AF
DTE
V
Y
H
R
F
E
I
-----------------------
E
RI
A
R
I
AFE
S
A
RK
R
-
R
HK
VTS
ID
K
A
N
V
L
QS
S
I-L
W
R
E
I
V
NE
IA
T
EY
--------------------
P
D
I
ELAHMY
ID
NATM
Q
L
I
KD
P
S
QFDV
L
L
CSNLFGDILSD
EC
A
M
I
TG
S
M
G
ML
PSA
S
LN
-
E
QG
F
-
G
L
Y
EP
A
G
GSAPDIAGKNIANPIA
Q
ILS
L
A
LL
LR
Y
S
L
DA
D
D
-
---
AA
SA
I
ER
AI
N
R
A
L
EE
G
IR
T
G
D
LA
R
---
GAA
AVS
T
D
E
M
GD
I
I
A
R
YVAEGV
fig|444449.5.peg.3990
Escherichia coli O157:H7 str. EC4042
MSKN
YH
IA
V
L
PGDGIG
P
EV
M
T
QA
LKVLDA
V
R
N
R
F
---
AMR
I
T
TSHYDV
G
GAA
-
IDN
HGQ
P
--
LP
PA
T
V
E
GCE
Q
A
DA
VL
FG
S
VG
GPK
W
EHLP
PD
QQ
P
ER
G
A
L
----
L
P
LR
K
H
F
K
L
F
S
NLRP
AK
LYQG
L
EAF
CPL
R
A
D
I
A
A
NGF
D
ILC
VRE
L
T
G
GIY
F
GQPK
GR
EG
SG
-
Q
Y
EK
AF
DTE
V
Y
H
R
F
E
I
-----------------------
E
RI
A
R
I
AFE
S
A
RK
R
-
R
HK
VTS
ID
K
A
N
V
L
QS
S
I-L
W
R
E
I
V
NE
IA
T
EY
--------------------
P
D
I
ELAHMY
ID
NATM
Q
L
I
KD
P
S
QFDV
L
L
CSNLFGDILSD
EC
A
M
I
TG
S
M
G
ML
PSA
S
LN
-
E
QG
F
-
G
L
Y
EP
A
G
GSAPDIAGKNIANPIA
Q
ILS
L
A
LL
LR
Y
S
L
DA
D
D
-
---
AA
SA
I
ER
AI
N
R
A
L
EE
G
IR
T
G
D
LA
R
---
GAA
AVS
T
D
E
M
GD
I
I
A
R
YVAEGV
fig|444448.5.peg.2749
Escherichia coli O157:H7 str. EC4045
MSKN
YH
IA
V
L
PGDGIG
P
EV
M
T
QA
LKVLDA
V
R
N
R
F
---
AMR
I
T
TSHYDV
G
GAA
-
IDN
HGQ
P
--
LP
PA
T
V
E
GCE
Q
A
DA
VL
FG
S
VG
GPK
W
EHLP
PD
QQ
P
ER
G
A
L
----
L
P
LR
K
H
F
K
L
F
S
NLRP
AK
LYQG
L
EAF
CPL
R
A
D
I
A
A
NGF
D
ILC
VRE
L
T
G
GIY
F
GQPK
GR
EG
SG
-
Q
Y
EK
AF
DTE
V
Y
H
R
F
E
I
-----------------------
E
RI
A
R
I
AFE
S
A
RK
R
-
R
HK
VTS
ID
K
A
N
V
L
QS
S
I-L
W
R
E
I
V
NE
IA
T
EY
--------------------
P
D
I
ELAHMY
ID
NATM
Q
L
I
KD
P
S
QFDV
L
L
CSNLFGDILSD
EC
A
M
I
TG
S
M
G
ML
PSA
S
LN
-
E
QG
F
-
G
L
Y
EP
A
G
GSAPDIAGKNIANPIA
Q
ILS
L
A
LL
LR
Y
S
L
DA
D
D
-
---
AA
SA
I
ER
AI
N
R
A
L
EE
G
IR
T
G
D
LA
R
---
GAA
AVS
T
D
E
M
GD
I
I
A
R
YVAEGV
fig|444453.5.peg.3352
Escherichia coli O157:H7 str. EC4076
MSKN
YH
IA
V
L
PGDGIG
P
EV
M
T
QA
LKVLDA
V
R
N
R
F
---
AMR
I
T
TSHYDV
G
GAA
-
IDN
HGQ
P
--
LP
PA
T
V
E
GCE
Q
A
DA
VL
FG
S
VG
GPK
W
EHLP
PD
QQ
P
ER
G
A
L
----
L
P
LR
K
H
F
K
L
F
S
NLRP
AK
LYQG
L
EAF
CPL
R
A
D
I
A
A
NGF
D
ILC
VRE
L
T
G
GIY
F
GQPK
GR
EG
SG
-
Q
Y
EK
AF
DTE
V
Y
H
R
F
E
I
-----------------------
E
RI
A
R
I
AFE
S
A
RK
R
-
R
HK
VTS
ID
K
A
N
V
L
QS
S
I-L
W
R
E
I
V
NE
IA
T
EY
--------------------
P
D
I
ELAHMY
ID
NATM
Q
L
I
KD
P
S
QFDV
L
L
CSNLFGDILSD
EC
A
M
I
TG
S
M
G
ML
PSA
S
LN
-
E
QG
F
-
G
L
Y
EP
A
G
GSAPDIAGKNIANPIA
Q
ILS
L
A
LL
LR
Y
S
L
DA
D
D
-
---
AA
SA
I
ER
AI
N
R
A
L
EE
G
IR
T
G
D
LA
R
---
GAA
AVS
T
D
E
M
GD
I
I
A
R
YVAEGV
fig|444452.5.peg.4324
Escherichia coli O157:H7 str. EC4113
MSKN
YH
IA
V
L
PGDGIG
P
EV
M
T
QA
LKVLDA
V
R
N
R
F
---
AMR
I
T
TSHYDV
G
GAA
-
IDN
HGQ
P
--
LP
PA
T
V
E
GCE
Q
A
DA
VL
FG
S
VG
GPK
W
EHLP
PD
QQ
P
ER
G
A
L
----
L
P
LR
K
H
F
K
L
F
S
NLRP
AK
LYQG
L
EAF
CPL
R
A
D
I
A
A
NGF
D
ILC
VRE
L
T
G
GIY
F
GQPK
GR
EG
SG
-
Q
Y
EK
AF
DTE
V
Y
H
R
F
E
I
-----------------------
E
RI
A
R
I
AFE
S
A
RK
R
-
R
HK
VTS
ID
K
A
N
V
L
QS
S
I-L
W
R
E
I
V
NE
IA
T
EY
--------------------
P
D
I
ELAHMY
ID
NATM
Q
L
I
KD
P
S
QFDV
L
L
CSNLFGDILSD
EC
A
M
I
TG
S
M
G
ML
PSA
S
LN
-
E
QG
F
-
G
L
Y
EP
A
G
GSAPDIAGKNIANPIA
Q
ILS
L
A
LL
LR
Y
S
L
DA
D
D
-
---
AA
SA
I
ER
AI
N
R
A
L
EE
G
IR
T
G
D
LA
R
---
GAA
AVS
T
D
E
M
GD
I
I
A
R
YVAEGV
fig|444450.8.peg.219
Escherichia coli O157:H7 str. EC4115
MSKN
YH
IA
V
L
PGDGIG
P
EV
M
T
QA
LKVLDA
V
R
N
R
F
---
AMR
I
T
TSHYDV
G
GAA
-
IDN
HGQ
P
--
LP
PA
T
V
E
GCE
Q
A
DA
VL
FG
S
VG
GPK
W
EHLP
PD
QQ
P
ER
G
A
L
----
L
P
LR
K
H
F
K
L
F
S
NLRP
AK
LYQG
L
EAF
CPL
R
A
D
I
A
A
NGF
D
ILC
VRE
L
T
G
GIY
F
GQPK
GR
EG
SG
-
Q
Y
EK
AF
DTE
V
Y
H
R
F
E
I
-----------------------
E
RI
A
R
I
AFE
S
A
RK
R
-
R
HK
VTS
ID
K
A
N
V
L
QS
S
I-L
W
R
E
I
V
NE
IA
T
EY
--------------------
P
D
I
ELAHMY
ID
NATM
Q
L
I
KD
P
S
QFDV
L
L
CSNLFGDILSD
EC
A
M
I
TG
S
M
G
ML
PSA
S
LN
-
E
QG
F
-
G
L
Y
EP
A
G
GSAPDIAGKNIANPIA
Q
ILS
L
A
LL
LR
Y
S
L
DA
D
D
-
---
AA
SA
I
ER
AI
N
R
A
L
EE
G
IR
T
G
D
LA
R
---
GAA
AVS
T
D
E
M
GD
I
I
A
R
YVAEGV
fig|444451.5.peg.4393
Escherichia coli O157:H7 str. EC4196
MSKN
YH
IA
V
L
PGDGIG
P
EV
M
T
QA
LKVLDA
V
R
N
R
F
---
AMR
I
T
TSHYDV
G
GAA
-
IDN
HGQ
P
--
LP
PA
T
V
E
GCE
Q
A
DA
VL
FG
S
VG
GPK
W
EHLP
PD
QQ
P
ER
G
A
L
----
L
P
LR
K
H
F
K
L
F
S
NLRP
AK
LYQG
L
EAF
CPL
R
A
D
I
A
A
NGF
D
ILC
VRE
L
T
G
GIY
F
GQPK
GR
EG
SG
-
Q
Y
EK
AF
DTE
V
Y
H
R
F
E
I
-----------------------
E
RI
A
R
I
AFE
S
A
RK
R
-
R
HK
VTS
ID
K
A
N
V
L
QS
S
I-L
W
R
E
I
V
NE
IA
T
EY
--------------------
P
D
I
ELAHMY
ID
NATM
Q
L
I
KD
P
S
QFDV
L
L
CSNLFGDILSD
EC
A
M
I
TG
S
M
G
ML
PSA
S
LN
-
E
QG
F
-
G
L
Y
EP
A
G
GSAPDIAGKNIANPIA
Q
ILS
L
A
LL
LR
Y
S
L
DA
D
D
-
---
AA
SA
I
ER
AI
N
R
A
L
EE
G
IR
T
G
D
LA
R
---
GAA
AVS
T
D
E
M
GD
I
I
A
R
YVAEGV
fig|444447.5.peg.2917
Escherichia coli O157:H7 str. EC4206
MSKN
YH
IA
V
L
PGDGIG
P
EV
M
T
QA
LKVLDA
V
R
N
R
F
---
AMR
I
T
TSHYDV
G
GAA
-
IDN
HGQ
P
--
LP
PA
T
V
E
GCE
Q
A
DA
VL
FG
S
VG
GPK
W
EHLP
PD
QQ
P
ER
G
A
L
----
L
P
LR
K
H
F
K
L
F
S
NLRP
AK
LYQG
L
EAF
CPL
R
A
D
I
A
A
NGF
D
ILC
VRE
L
T
G
GIY
F
GQPK
GR
EG
SG
-
Q
Y
EK
AF
DTE
V
Y
H
R
F
E
I
-----------------------
E
RI
A
R
I
AFE
S
A
RK
R
-
R
HK
VTS
ID
K
A
N
V
L
QS
S
I-L
W
R
E
I
V
NE
IA
T
EY
--------------------
P
D
I
ELAHMY
ID
NATM
Q
L
I
KD
P
S
QFDV
L
L
CSNLFGDILSD
EC
A
M
I
TG
S
M
G
ML
PSA
S
LN
-
E
QG
F
-
G
L
Y
EP
A
G
GSAPDIAGKNIANPIA
Q
ILS
L
A
LL
LR
Y
S
L
DA
D
D
-
---
AA
SA
I
ER
AI
N
R
A
L
EE
G
IR
T
G
D
LA
R
---
GAA
AVS
T
D
E
M
GD
I
I
A
R
YVAEGV
fig|478004.5.peg.2449
Escherichia coli O157:H7 str. EC4401
MSKN
YH
IA
V
L
PGDGIG
P
EV
M
T
QA
LKVLDA
V
R
N
R
F
---
AMR
I
T
TSHYDV
G
GAA
-
IDN
HGQ
P
--
LP
PA
T
V
E
GCE
Q
A
DA
VL
FG
S
VG
GPK
W
EHLP
PD
QQ
P
ER
G
A
L
----
L
P
LR
K
H
F
K
L
F
S
NLRP
AK
LYQG
L
EAF
CPL
R
A
D
I
A
A
NGF
D
ILC
VRE
L
T
G
GIY
F
GQPK
GR
EG
SG
-
Q
Y
EK
AF
DTE
V
Y
H
R
F
E
I
-----------------------
E
RI
A
R
I
AFE
S
A
RK
R
-
R
HK
VTS
ID
K
A
N
V
L
QS
S
I-L
W
R
E
I
V
NE
IA
T
EY
--------------------
P
D
I
ELAHMY
ID
NATM
Q
L
I
KD
P
S
QFDV
L
L
CSNLFGDILSD
EC
A
M
I
TG
S
M
G
ML
PSA
S
LN
-
E
QG
F
-
G
L
Y
EP
A
G
GSAPDIAGKNIANPIA
Q
ILS
L
A
LL
LR
Y
S
L
DA
D
D
-
---
AA
SA
I
ER
AI
N
R
A
L
EE
G
IR
T
G
D
LA
R
---
GAA
AVS
T
D
E
M
GD
I
I
A
R
YVAEGV
fig|478005.5.peg.4945
Escherichia coli O157:H7 str. EC4486
MSKN
YH
IA
V
L
PGDGIG
P
EV
M
T
QA
LKVLDA
V
R
N
R
F
---
AMR
I
T
TSHYDV
G
GAA
-
IDN
HGQ
P
--
LP
PA
T
V
E
GCE
Q
A
DA
VL
FG
S
VG
GPK
W
EHLP
PD
QQ
P
ER
G
A
L
----
L
P
LR
K
H
F
K
L
F
S
NLRP
AK
LYQG
L
EAF
CPL
R
A
D
I
A
A
NGF
D
ILC
VRE
L
T
G
GIY
F
GQPK
GR
EG
SG
-
Q
Y
EK
AF
DTE
V
Y
H
R
F
E
I
-----------------------
E
RI
A
R
I
AFE
S
A
RK
R
-
R
HK
VTS
ID
K
A
N
V
L
QS
S
I-L
W
R
E
I
V
NE
IA
T
EY
--------------------
P
D
I
ELAHMY
ID
NATM
Q
L
I
KD
P
S
QFDV
L
L
CSNLFGDILSD
EC
A
M
I
TG
S
M
G
ML
PSA
S
LN
-
E
QG
F
-
G
L
Y
EP
A
G
GSAPDIAGKNIANPIA
Q
ILS
L
A
LL
LR
Y
S
L
DA
D
D
-
---
AA
SA
I
ER
AI
N
R
A
L
EE
G
IR
T
G
D
LA
R
---
GAA
AVS
T
D
E
M
GD
I
I
A
R
YVAEGV
fig|478006.5.peg.4393
Escherichia coli O157:H7 str. EC4501
MSKN
YH
IA
V
L
PGDGIG
P
EV
M
T
QA
LKVLDA
V
R
N
R
F
---
AMR
I
T
TSHYDV
G
GAA
-
IDN
HGQ
P
--
LP
PA
T
V
E
GCE
Q
A
DA
VL
FG
S
VG
GPK
W
EHLP
PD
QQ
P
ER
G
A
L
----
L
P
LR
K
H
F
K
L
F
S
NLRP
AK
LYQG
L
EAF
CPL
R
A
D
I
A
A
NGF
D
ILC
VRE
L
T
G
GIY
F
GQPK
GR
EG
SG
-
Q
Y
EK
AF
DTE
V
Y
H
R
F
E
I
-----------------------
E
RI
A
R
I
AFE
S
A
RK
R
-
R
HK
VTS
ID
K
A
N
V
L
QS
S
I-L
W
R
E
I
V
NE
IA
T
EY
--------------------
P
D
I
ELAHMY
ID
NATM
Q
L
I
KD
P
S
QFDV
L
L
CSNLFGDILSD
EC
A
M
I
TG
S
M
G
ML
PSA
S
LN
-
E
QG
F
-
G
L
Y
EP
A
G
GSAPDIAGKNIANPIA
Q
ILS
L
A
LL
LR
Y
S
L
DA
D
D
-
---
AA
SA
I
ER
AI
N
R
A
L
EE
G
IR
T
G
D
LA
R
---
GAA
AVS
T
D
E
M
GD
I
I
A
R
YVAEGV
fig|478007.5.peg.4107
Escherichia coli O157:H7 str. EC508
MSKN
YH
IA
V
L
PGDGIG
P
EV
M
T
QA
LKVLDA
V
R
N
R
F
---
AMR
I
T
TSHYDV
G
GAA
-
IDN
HGQ
P
--
LP
PA
T
V
E
GCE
Q
A
DA
VL
FG
S
VG
GPK
W
EHLP
PD
QQ
P
ER
G
A
L
----
L
P
LR
K
H
F
K
L
F
S
NLRP
AK
LYQG
L
EAF
CPL
R
A
D
I
A
A
NGF
D
ILC
VRE
L
T
G
GIY
F
GQPK
GR
EG
SG
-
Q
Y
EK
AF
DTE
V
Y
H
R
F
E
I
-----------------------
E
RI
A
R
I
AFE
S
A
RK
R
-
R
HK
VTS
ID
K
A
N
V
L
QS
S
I-L
W
R
E
I
V
NE
IA
T
EY
--------------------
P
D
I
ELAHMY
ID
NATM
Q
L
I
KD
P
S
QFDV
L
L
CSNLFGDILSD
EC
A
M
I
TG
S
M
G
ML
PSA
S
LN
-
E
QG
F
-
G
L
Y
EP
A
G
GSAPDIAGKNIANPIA
Q
ILS
L
A
LL
LR
Y
S
L
DA
D
D
-
---
AA
SA
I
ER
AI
N
R
A
L
EE
G
IR
T
G
D
LA
R
---
GAA
AVS
T
D
E
M
GD
I
I
A
R
YVAEGV
fig|478008.5.peg.4664
Escherichia coli O157:H7 str. EC869
MSKN
YH
IA
V
L
PGDGIG
P
EV
M
T
QA
LKVLDA
V
R
N
R
F
---
AMR
I
T
TSHYDV
G
GAA
-
IDN
HGQ
P
--
LP
PA
T
V
E
GCE
Q
A
DA
VL
FG
S
VG
GPK
W
EHLP
PD
QQ
P
ER
G
A
L
----
L
P
LR
K
H
F
K
L
F
S
NLRP
AK
LYQG
L
EAF
CPL
R
A
D
I
A
A
NGF
D
ILC
VRE
L
T
G
GIY
F
GQPK
GR
EG
SG
-
Q
Y
EK
AF
DTE
V
Y
H
R
F
E
I
-----------------------
E
RI
A
R
I
AFE
S
A
RK
R
-
R
HK
VTS
ID
K
A
N
V
L
QS
S
I-L
W
R
E
I
V
NE
IA
T
EY
--------------------
P
D
I
ELAHMY
ID
NATM
Q
L
I
KD
P
S
QFDV
L
L
CSNLFGDILSD
EC
A
M
I
TG
S
M
G
ML
PSA
S
LN
-
E
QG
F
-
G
L
Y
EP
A
G
GSAPDIAGKNIANPIA
Q
ILS
L
A
LL
LR
Y
S
L
DA
D
D
-
---
AA
SA
I
ER
AI
N
R
A
L
EE
G
IR
T
G
D
LA
R
---
GAA
AVS
T
D
E
M
GD
I
I
A
R
YVAEGV
fig|637388.3.peg.3916
Escherichia coli O157:H7 str. FRIK2000
MSKN
YH
IA
V
L
PGDGIG
P
EV
M
T
QA
LKVLDA
V
R
N
R
F
---
AMR
I
T
TSHYDV
G
GAA
-
IDN
HGQ
P
--
LP
PA
T
V
E
GCE
Q
A
DA
VL
FG
S
VG
GPK
W
EHLP
PD
QQ
P
ER
G
A
L
----
L
P
LR
K
H
F
K
L
F
S
NLRP
AK
LYQG
L
EAF
CPL
R
A
D
I
A
A
NGF
D
ILC
VRE
L
T
G
GIY
F
GQPK
GR
EG
SG
-
Q
Y
EK
AF
DTE
V
Y
H
R
F
E
I
-----------------------
E
RI
A
R
I
AFE
S
A
RK
R
-
R
HK
VTS
ID
K
A
N
V
L
QS
S
I-L
W
R
E
I
V
NE
IA
T
EY
--------------------
P
D
I
ELAHMY
ID
NATM
Q
L
I
KD
P
S
QFDV
L
L
CSNLFGDILSD
EC
A
M
I
TG
S
M
G
ML
PSA
S
LN
-
E
QG
F
-
G
L
Y
EP
A
G
GSAPDIAGKNIANPIA
Q
ILS
L
A
LL
LR
Y
S
L
DA
D
D
-
---
AA
SA
I
ER
AI
N
R
A
L
EE
G
IR
T
G
D
LA
R
---
GAA
AVS
T
D
E
M
GD
I
I
A
R
YVAEGV
fig|570506.3.peg.1081
Escherichia coli O157:H7 str. FRIK966
MSKN
YH
IA
V
L
PGDGIG
P
EV
M
T
QA
LKVLDA
V
R
N
R
F
---
AMR
I
T
TSHYDV
G
GAA
-
IDN
HGQ
P
--
LP
PA
T
V
E
GCE
Q
A
DA
VL
FG
S
VG
GPK
W
EHLP
PD
QQ
P
ER
G
A
L
----
L
P
LR
K
H
F
K
L
F
S
NLRP
AK
LYQG
L
EAF
CPL
R
A
D
I
A
A
NGF
D
ILC
VRE
L
T
G
GIY
F
GQPK
GR
EG
SG
-
Q
Y
EK
AF
DTE
V
Y
H
R
F
E
I
-----------------------
E
RI
A
R
I
AFE
S
A
RK
R
-
R
HK
VTS
ID
K
A
N
V
L
QS
S
I-L
W
R
E
I
V
NE
IA
T
EY
--------------------
P
D
I
ELAHMY
ID
NATM
Q
L
I
KD
P
S
QFDV
L
L
CSNLFGDILSD
EC
A
M
I
TG
S
M
G
ML
PSA
S
LN
-
E
QG
F
-
G
L
Y
EP
A
G
GSAPDIAGKNIANPIA
Q
ILS
L
A
LL
LR
Y
S
L
DA
D
D
-
---
AA
SA
I
ER
AI
N
R
A
L
EE
G
IR
T
G
D
LA
R
---
GAA
AVS
T
D
E
M
GD
I
I
A
R
YVAEGV
fig|386585.9.peg.177
Escherichia coli O157:H7 str. Sakai
MSKN
YH
IA
V
L
PGDGIG
P
EV
M
T
QA
LKVLDA
V
R
N
R
F
---
AMR
I
T
TSHYDV
G
GAA
-
IDN
HGQ
P
--
LP
PA
T
V
E
GCE
Q
A
DA
VL
FG
S
VG
GPK
W
EHLP
PD
QQ
P
ER
G
A
L
----
L
P
LR
K
H
F
K
L
F
S
NLRP
AK
LYQG
L
EAF
CPL
R
A
D
I
A
A
NGF
D
ILC
VRE
L
T
G
GIY
F
GQPK
GR
EG
SG
-
Q
Y
EK
AF
DTE
V
Y
H
R
F
E
I
-----------------------
E
RI
A
R
I
AFE
S
A
RK
R
-
R
HK
VTS
ID
K
A
N
V
L
QS
S
I-L
W
R
E
I
V
NE
IA
T
EY
--------------------
P
D
I
ELAHMY
ID
NATM
Q
L
I
KD
P
S
QFDV
L
L
CSNLFGDILSD
EC
A
M
I
TG
S
M
G
ML
PSA
S
LN
-
E
QG
F
-
G
L
Y
EP
A
G
GSAPDIAGKNIANPIA
Q
ILS
L
A
LL
LR
Y
S
L
DA
D
D
-
---
AA
SA
I
ER
AI
N
R
A
L
EE
G
IR
T
G
D
LA
R
---
GAA
AVS
T
D
E
M
GD
I
I
A
R
YVAEGV
fig|544404.4.peg.81
Escherichia coli O157:H7 str. TW14359
MSKN
YH
IA
V
L
PGDGIG
P
EV
M
T
QA
LKVLDA
V
R
N
R
F
---
AMR
I
T
TSHYDV
G
GAA
-
IDN
HGQ
P
--
LP
PA
T
V
E
GCE
Q
A
DA
VL
FG
S
VG
GPK
W
EHLP
PD
QQ
P
ER
G
A
L
----
L
P
LR
K
H
F
K
L
F
S
NLRP
AK
LYQG
L
EAF
CPL
R
A
D
I
A
A
NGF
D
ILC
VRE
L
T
G
GIY
F
GQPK
GR
EG
SG
-
Q
Y
EK
AF
DTE
V
Y
H
R
F
E
I
-----------------------
E
RI
A
R
I
AFE
S
A
RK
R
-
R
HK
VTS
ID
K
A
N
V
L
QS
S
I-L
W
R
E
I
V
NE
IA
T
EY
--------------------
P
D
I
ELAHMY
ID
NATM
Q
L
I
KD
P
S
QFDV
L
L
CSNLFGDILSD
EC
A
M
I
TG
S
M
G
ML
PSA
S
LN
-
E
QG
F
-
G
L
Y
EP
A
G
GSAPDIAGKNIANPIA
Q
ILS
L
A
LL
LR
Y
S
L
DA
D
D
-
---
AA
SA
I
ER
AI
N
R
A
L
EE
G
IR
T
G
D
LA
R
---
GAA
AVS
T
D
E
M
GD
I
I
A
R
YVAEGV
fig|502346.5.peg.1186
Escherichia coli O157:H7 str. TW14588
MSKN
YH
IA
V
L
PGDGIG
P
EV
M
T
QA
LKVLDA
V
R
N
R
F
---
AMR
I
T
TSHYDV
G
GAA
-
IDN
HGQ
P
--
LP
PA
T
V
E
GCE
Q
A
DA
VL
FG
S
VG
GPK
W
EHLP
PD
QQ
P
ER
G
A
L
----
L
P
LR
K
H
F
K
L
F
S
NLRP
AK
LYQG
L
EAF
CPL
R
A
D
I
A
A
NGF
D
ILC
VRE
L
T
G
GIY
F
GQPK
GR
EG
SG
-
Q
Y
EK
AF
DTE
V
Y
H
R
F
E
I
-----------------------
E
RI
A
R
I
AFE
S
A
RK
R
-
R
HK
VTS
ID
K
A
N
V
L
QS
S
I-L
W
R
E
I
V
NE
IA
T
EY
--------------------
P
D
I
ELAHMY
ID
NATM
Q
L
I
KD
P
S
QFDV
L
L
CSNLFGDILSD
EC
A
M
I
TG
S
M
G
ML
PSA
S
LN
-
E
QG
F
-
G
L
Y
EP
A
G
GSAPDIAGKNIANPIA
Q
ILS
L
A
LL
LR
Y
S
L
DA
D
D
-
---
AA
SA
I
ER
AI
N
R
A
L
EE
G
IR
T
G
D
LA
R
---
GAA
AVS
T
D
E
M
GD
I
I
A
R
YVAEGV
fig|701177.3.peg.78
Escherichia coli O55:H7 str. CB9615
MSKN
YH
IA
V
L
PGDGIG
P
EV
M
T
QA
LKVLDA
V
R
N
R
F
---
AMR
I
T
TSHYDV
G
GAA
-
IDN
HGQ
P
--
LP
PA
T
V
E
GCE
Q
A
DA
VL
FG
S
VG
GPK
W
EHLP
PD
QQ
P
ER
G
A
L
----
L
P
LR
K
H
F
K
L
F
S
NLRP
AK
LYQG
L
EAF
CPL
R
A
D
I
A
A
NGF
D
ILC
VRE
L
T
G
GIY
F
GQPK
GR
EG
SG
-
Q
Y
EK
AF
DTE
V
Y
H
R
F
E
I
-----------------------
E
RI
A
R
I
AFE
S
A
RK
R
-
R
HK
VTS
ID
K
A
N
V
L
QS
S
I-L
W
R
E
I
V
NE
IA
T
EY
--------------------
P
D
I
ELAHMY
ID
NATM
Q
L
I
KD
P
S
QFDV
L
L
CSNLFGDILSD
EC
A
M
I
TG
S
M
G
ML
PSA
S
LN
-
E
QG
F
-
G
L
Y
EP
A
G
GSAPDIAGKNIANPIA
Q
ILS
L
A
LL
LR
Y
S
L
DA
D
D
-
---
AA
SA
I
ER
AI
N
R
A
L
EE
G
IR
T
G
D
LA
R
---
GAA
AVS
T
D
E
M
GD
I
I
A
R
YVAEGV
fig|525281.3.peg.1194
Escherichia coli 83972
MSKN
YH
IA
V
L
PGDGIG
P
EV
M
T
QA
LKVLDA
V
R
N
R
F
---
AMR
I
T
TSHYDV
G
GAA
-
IDN
HGQ
P
--
LP
PA
T
V
E
GCE
Q
A
DA
VL
FG
S
VG
GPK
W
EHLP
PD
QQ
P
ER
G
A
L
----
L
P
LR
K
H
F
K
L
F
S
NLRP
AK
LYQG
L
EAF
CPL
R
A
D
I
A
A
NGF
D
ILC
VRE
L
T
G
GIY
F
GQPK
GR
EG
SG
-
Q
Y
EK
AF
DTE
V
Y
H
R
F
E
I
-----------------------
E
RI
A
R
I
AFE
S
A
RK
R
-
R
HK
VTS
ID
K
A
N
V
L
QS
S
I-L
W
R
E
I
V
NE
IA
T
EY
--------------------
P
DV
ELTHMY
ID
NATM
Q
L
I
KD
P
S
QFDV
L
L
CSNLFGDILSD
EC
A
M
I
TG
S
M
G
ML
PSA
S
LN
-
E
QG
F
-
G
L
Y
EP
A
G
GSAPDIAGKNIANPIA
Q
ILS
L
A
LL
LR
Y
S
L
DA
D
D
-
---
AA
SA
I
ER
AI
N
R
A
L
EE
G
IR
T
G
D
LA
R
---
GAA
AVS
T
D
E
M
GD
I
I
A
R
YVAEGV
fig|655817.3.peg.84
Escherichia coli ABU 83972
MSKN
YH
IA
V
L
PGDGIG
P
EV
M
T
QA
LKVLDA
V
R
N
R
F
---
AMR
I
T
TSHYDV
G
GAA
-
IDN
HGQ
P
--
LP
PA
T
V
E
GCE
Q
A
DA
VL
FG
S
VG
GPK
W
EHLP
PD
QQ
P
ER
G
A
L
----
L
P
LR
K
H
F
K
L
F
S
NLRP
AK
LYQG
L
EAF
CPL
R
A
D
I
A
A
NGF
D
ILC
VRE
L
T
G
GIY
F
GQPK
GR
EG
SG
-
Q
Y
EK
AF
DTE
V
Y
H
R
F
E
I
-----------------------
E
RI
A
R
I
AFE
S
A
RK
R
-
R
HK
VTS
ID
K
A
N
V
L
QS
S
I-L
W
R
E
I
V
NE
IA
T
EY
--------------------
P
DV
ELTHMY
ID
NATM
Q
L
I
KD
P
S
QFDV
L
L
CSNLFGDILSD
EC
A
M
I
TG
S
M
G
ML
PSA
S
LN
-
E
QG
F
-
G
L
Y
EP
A
G
GSAPDIAGKNIANPIA
Q
ILS
L
A
LL
LR
Y
S
L
DA
D
D
-
---
AA
SA
I
ER
AI
N
R
A
L
EE
G
IR
T
G
D
LA
R
---
GAA
AVS
T
D
E
M
GD
I
I
A
R
YVAEGV
fig|199310.1.peg.86
Escherichia coli CFT073 (2-364/364)
MSKN
YH
IA
V
L
PGDGIG
P
EV
M
T
QA
LKVLDA
V
R
N
R
F
---
AMR
I
T
TSHYDV
G
GAA
-
IDN
HGQ
P
--
LP
PA
T
V
E
GCE
Q
A
DA
VL
FG
S
VG
GPK
W
EHLP
PD
QQ
P
ER
G
A
L
----
L
P
LR
K
H
F
K
L
F
S
NLRP
AK
LYQG
L
EAF
CPL
R
A
D
I
A
A
NGF
D
ILC
VRE
L
T
G
GIY
F
GQPK
GR
EG
SG
-
Q
Y
EK
AF
DTE
V
Y
H
R
F
E
I
-----------------------
E
RI
A
R
I
AFE
S
A
RK
R
-
R
HK
VTS
ID
K
A
N
V
L
QS
S
I-L
W
R
E
I
V
NE
IA
T
EY
--------------------
P
DV
ELTHMY
ID
NATM
Q
L
I
KD
P
S
QFDV
L
L
CSNLFGDILSD
EC
A
M
I
TG
S
M
G
ML
PSA
S
LN
-
E
QG
F
-
G
L
Y
EP
A
G
GSAPDIAGKNIANPIA
Q
ILS
L
A
LL
LR
Y
S
L
DA
D
D
-
---
AA
SA
I
ER
AI
N
R
A
L
EE
G
IR
T
G
D
LA
R
---
GAA
AVS
T
D
E
M
GD
I
I
A
R
YVAEGV
fig|199310.4.peg.85
Escherichia coli CFT073
MSKN
YH
IA
V
L
PGDGIG
P
EV
M
T
QA
LKVLDA
V
R
N
R
F
---
AMR
I
T
TSHYDV
G
GAA
-
IDN
HGQ
P
--
LP
PA
T
V
E
GCE
Q
A
DA
VL
FG
S
VG
GPK
W
EHLP
PD
QQ
P
ER
G
A
L
----
L
P
LR
K
H
F
K
L
F
S
NLRP
AK
LYQG
L
EAF
CPL
R
A
D
I
A
A
NGF
D
ILC
VRE
L
T
G
GIY
F
GQPK
GR
EG
SG
-
Q
Y
EK
AF
DTE
V
Y
H
R
F
E
I
-----------------------
E
RI
A
R
I
AFE
S
A
RK
R
-
R
HK
VTS
ID
K
A
N
V
L
QS
S
I-L
W
R
E
I
V
NE
IA
T
EY
--------------------
P
DV
ELTHMY
ID
NATM
Q
L
I
KD
P
S
QFDV
L
L
CSNLFGDILSD
EC
A
M
I
TG
S
M
G
ML
PSA
S
LN
-
E
QG
F
-
G
L
Y
EP
A
G
GSAPDIAGKNIANPIA
Q
ILS
L
A
LL
LR
Y
S
L
DA
D
D
-
---
AA
SA
I
ER
AI
N
R
A
L
EE
G
IR
T
G
D
LA
R
---
GAA
AVS
T
D
E
M
GD
I
I
A
R
YVAEGV
fig|656417.3.peg.137
Escherichia coli M605
MSKN
YH
IA
V
L
PGDGIG
P
EV
M
T
QA
LKVLDA
V
R
N
R
F
---
AMR
I
T
TSHYDV
G
GAA
-
IDN
HGQ
P
--
LP
PA
T
V
E
GCE
Q
A
DA
VL
FG
S
VG
GPK
W
EHLP
PD
QQ
P
ER
G
A
L
----
L
P
LR
K
H
F
K
L
F
S
NLRP
AK
LYQG
L
EAF
CPL
R
A
D
I
A
A
NGF
D
ILC
VRE
L
T
G
GIY
F
GQPK
GR
EG
SG
-
Q
Y
EK
AF
DTE
V
Y
H
R
F
E
I
-----------------------
E
RI
A
R
I
AFE
S
A
RK
R
-
R
HK
VTS
ID
K
A
N
V
L
QS
S
I-L
W
R
E
I
V
NE
IA
T
EY
--------------------
P
DV
ELAHMY
ID
NATM
Q
L
I
KD
P
S
QFDV
L
L
CSNLFGDILSD
EC
A
M
I
TG
S
M
G
ML
PSA
S
LN
-
E
QG
F
-
G
L
Y
EP
A
G
GSAPDIAGKNIANPIA
Q
ILS
L
A
LL
LR
Y
S
L
DA
D
D
-
---
AA
SA
I
ER
AI
N
R
A
L
EE
G
IR
T
G
D
LA
R
---
G
T
A
AVS
T
D
E
M
GD
I
I
A
R
YVAEGV
fig|749546.3.peg.2381
Escherichia coli MS 185-1
MSKN
YH
IA
V
L
PGDGIG
P
EV
M
T
QA
LKVLDA
V
R
N
R
F
---
AMR
I
T
TSHYDV
G
GAA
-
IDN
HGQ
P
--
LP
PA
T
V
E
GCE
Q
A
DA
VL
FG
S
VG
GPK
W
EHLP
PD
QQ
P
ER
G
A
L
----
L
P
LR
K
H
F
K
L
F
S
NLRP
AK
LYQG
L
EAF
CPL
R
A
D
I
A
A
NGF
D
ILC
VRE
L
T
G
GIY
F
GQPK
GR
EG
SG
-
Q
Y
EK
AF
DTE
V
Y
H
R
F
E
I
-----------------------
E
RI
A
R
I
AFE
S
A
RK
R
-
R
HK
VTS
ID
K
A
N
V
L
QS
S
I-L
W
R
E
I
V
NE
IA
T
EY
--------------------
P
DV
ELTHMY
ID
NATM
Q
L
I
KD
P
S
QFDV
L
L
CSNLFGDILSD
EC
A
M
I
TG
S
M
G
ML
PSA
S
LN
-
E
QG
F
-
G
L
Y
EP
A
G
GSAPDIAGKNIANPIA
Q
ILS
L
A
LL
LR
Y
S
L
DA
D
D
-
---
AA
SA
I
ER
AI
N
R
A
L
EE
G
IR
T
G
D
LA
R
---
GAA
AVS
T
D
E
M
GD
I
I
A
R
YVAEGV
fig|749528.3.peg.2226
Escherichia coli MS 45-1
MSKN
YH
IA
V
L
PGDGIG
P
EV
M
T
QA
LKVLDA
V
R
N
R
F
---
AMR
I
T
TSHYDV
G
GAA
-
IDN
HGQ
P
--
LP
PA
T
V
E
GCE
Q
A
DA
VL
FG
S
VG
GPK
W
EHLP
PD
QQ
P
ER
G
A
L
----
L
P
LR
K
H
F
K
L
F
S
NLRP
AK
LYQG
L
EAF
CPL
R
A
D
I
A
A
NGF
D
ILC
VRE
L
T
G
GIY
F
GQPK
GR
EG
SG
-
Q
Y
EK
AF
DTE
V
Y
H
R
F
E
I
-----------------------
E
RI
A
R
I
AFE
S
A
RK
R
-
R
HK
VTS
ID
K
A
N
V
L
QS
S
I-L
W
R
E
I
V
NE
IA
T
EY
--------------------
P
DV
ELTHMY
ID
NATM
Q
L
I
KD
P
S
QFDV
L
L
CSNLFGDILSD
EC
A
M
I
TG
S
M
G
ML
PSA
S
LN
-
E
QG
F
-
G
L
Y
EP
A
G
GSAPDIAGKNIANPIA
Q
ILS
L
A
LL
LR
Y
S
L
DA
D
D
-
---
AA
SA
I
ER
AI
N
R
A
L
EE
G
IR
T
G
D
LA
R
---
GAA
AVS
T
D
E
M
GD
I
I
A
R
YVAEGV
fig|685038.3.peg.75
Escherichia coli O83:H1 str. NRG 857C
MSKN
YH
IA
V
L
PGDGIG
P
EV
M
T
QA
LKVLDA
V
R
N
R
F
---
AMR
I
T
TSHYDV
G
GAA
-
IDN
HGQ
P
--
LP
PA
T
V
E
GCE
Q
A
DA
VL
FG
S
VG
GPK
W
EHLP
PD
QQ
P
ER
G
A
L
----
L
P
LR
K
H
F
K
L
F
S
NLRP
AK
LYQG
L
EAF
CPL
R
A
D
I
A
A
NGF
D
ILC
VRE
L
T
G
GIY
F
GQPK
GR
EG
SG
-
Q
Y
EK
AF
DTE
V
Y
H
R
F
E
I
-----------------------
E
RI
A
R
I
AFE
S
A
RK
R
-
R
HK
VTS
ID
K
A
N
V
L
QS
S
I-L
W
R
E
I
V
NE
IA
T
EY
--------------------
P
DV
ELTHMY
ID
NATM
Q
L
I
KD
P
S
QFDV
L
L
CSNLFGDILSD
EC
A
M
I
TG
S
M
G
ML
PSA
S
LN
-
E
QG
F
-
G
L
Y
EP
A
G
GSAPDIAGKNIANPIA
Q
ILS
L
A
LL
LR
Y
S
L
DA
D
D
-
---
AA
SA
I
ER
AI
N
R
A
L
EE
G
IR
T
G
D
LA
R
---
GAA
AVS
T
D
E
M
GD
I
I
A
R
YVAEGV
fig|656444.3.peg.408
Escherichia coli TA280
MSKN
YH
IA
V
L
PGDGIG
P
EV
M
T
QA
LKVLDA
V
R
N
R
F
---
TMR
I
T
TSHYDV
G
GAA
-
IDN
HGQ
P
--
LP
PA
T
V
E
GCE
Q
A
DA
VL
FG
S
VG
GPK
W
EHLP
PD
QQ
P
ER
G
A
L
----
L
P
LR
K
H
F
K
L
F
S
NLRP
AK
LYQG
L
EAF
CPL
R
A
D
I
A
A
NGF
D
ILC
VRE
L
T
G
GIY
F
GQPK
GR
EG
SG
-
Q
Y
EK
AF
DTE
V
Y
H
R
F
E
I
-----------------------
E
RI
A
R
I
AFE
S
A
RK
R
-
R
HK
VTS
ID
K
A
N
V
L
QS
S
I-L
W
R
E
I
V
NE
IA
T
EY
--------------------
P
DV
ELAHMY
ID
NATM
Q
L
I
KD
P
S
QFDV
L
L
CSNLFGDILSD
EC
A
M
I
TG
S
M
G
ML
PSA
S
LN
-
E
QG
F
-
G
L
Y
EP
A
G
GSAPDIAGKNIANPIA
Q
ILS
L
A
LL
LR
Y
S
L
DA
D
D
-
---
AA
SA
I
ER
AI
N
R
A
L
EE
G
IR
T
G
D
LA
R
---
GAA
AVS
T
D
E
M
GD
I
I
A
R
YVAEGV
fig|562.376.peg.1235
Escherichia coli WV_060327
MSKN
YH
IA
V
L
PGDGIG
P
EV
M
T
QA
LKVLDA
V
R
N
R
F
---
AMR
I
T
TSHYDV
G
GAA
-
IDN
HGQ
P
--
LP
PA
T
V
E
GCE
Q
A
DA
VL
FG
S
VG
GPK
W
EHLP
PD
QQ
P
ER
G
A
L
----
L
P
LR
K
H
F
K
L
F
S
NLRP
AK
LYQG
L
EAF
CPL
R
A
D
I
A
A
NGF
D
ILC
VRE
L
T
G
GIY
F
GQPK
GR
EG
SG
-
Q
Y
EK
AF
DTE
V
Y
H
R
F
E
I
-----------------------
E
RI
A
R
I
AFE
S
A
RK
R
-
R
HK
VTS
ID
K
A
N
V
L
QS
S
I-L
W
R
E
I
V
NE
IA
T
EY
--------------------
P
DV
ELTHMY
ID
NATM
Q
L
I
KD
P
S
QFDV
L
L
CSNLFGDILSD
EC
A
M
I
TG
S
M
G
ML
PSA
S
LN
-
E
QG
F
-
G
L
Y
EP
A
G
GSAPDIAGKNIANPIA
Q
ILS
L
A
LL
LR
Y
S
L
DA
D
D
-
---
AA
SA
I
ER
AI
N
R
A
L
EE
G
IR
T
G
D
LA
R
---
GAA
AVS
T
D
E
M
GD
I
I
A
R
YVAEGV
fig|550677.3.peg.462
Escherichia coli B354
MSKN
YH
IA
V
L
PGDGIG
P
EV
M
T
QA
LKVLDA
V
R
N
R
F
---
AMR
I
T
TSHYDV
G
GAA
-
IDN
HGQ
P
--
LP
PA
T
V
E
GCE
Q
A
DA
VL
FG
S
VG
GPK
W
EHLP
PD
QQ
P
ER
G
A
L
----
L
P
LR
K
H
F
K
L
F
S
NLRP
AK
LYQG
L
EAF
CPL
R
A
D
I
A
A
NGF
D
ILC
VRE
L
T
G
GIY
F
GQPK
GR
EG
SG
-
Q
Y
EK
AF
DTE
V
Y
H
R
F
E
I
-----------------------
E
RI
A
R
I
AFE
S
A
RK
R
-
R
HK
VTS
ID
K
A
N
V
L
QS
S
I-L
W
R
E
I
V
NE
IA
T
EY
--------------------
P
DV
ELAHMY
ID
NATM
Q
L
I
KD
P
S
QFDV
L
L
CSNLFGDILSD
EC
A
M
I
TG
S
M
G
ML
PSA
S
LN
-
E
QG
F
-
G
L
Y
EP
A
G
GSAPDIAGKNIANPIA
Q
ILS
L
A
LL
LR
Y
S
L
DA
D
D
-
---
AA
SA
I
ER
AI
N
R
A
L
EE
G
IR
T
G
D
LA
R
---
GAA
AVS
T
N
E
M
GD
I
I
A
R
YVAEGV
fig|656379.3.peg.314
Escherichia coli FVEC1302
MSKN
YH
IA
V
L
PGDGIG
P
EV
M
T
QA
LKVLDA
V
R
N
R
F
---
AMR
I
T
TSHYDV
G
GAA
-
IDN
HGQ
P
--
LP
PA
T
V
E
GCE
Q
A
DA
VL
FG
S
VG
GPK
W
EHLP
PD
QQ
P
ER
G
A
L
----
L
P
LR
K
H
F
K
L
F
S
NLRP
AK
LYQG
L
EAF
CPL
R
A
D
I
A
A
NGF
D
ILC
VRE
L
T
G
GIY
F
GQPK
GR
EG
SG
-
Q
Y
EK
AF
DTE
V
Y
H
R
F
E
I
-----------------------
E
RI
A
R
I
AFE
S
A
RK
R
-
R
HK
VTS
ID
K
A
N
V
L
QS
S
I-L
W
R
E
I
V
NE
IA
T
EY
--------------------
P
DV
ELAHMY
ID
NATM
Q
L
I
KD
P
S
QFDV
L
L
CSNLFGDILSD
EC
A
M
I
TG
S
M
G
ML
PSA
S
LN
-
E
QG
F
-
G
L
Y
EP
A
G
GSAPDIAGKNIANPIA
Q
ILS
L
A
LL
LR
Y
S
L
DA
D
D
-
---
AA
SA
I
ER
AI
N
R
A
L
EE
G
IR
T
G
D
LA
R
---
GAA
AVS
T
N
E
M
GD
I
I
A
R
YVAEGV
fig|749549.3.peg.4578
Escherichia coli MS 198-1
MSKN
YH
IA
V
L
PGDGIG
P
EV
M
T
QA
LKVLDA
V
R
N
R
F
---
AMR
I
T
TSHYDV
G
GAA
-
IDN
HGQ
P
--
LP
PA
T
V
E
GCE
Q
A
DA
VL
FG
S
VG
GPK
W
EHLP
PD
QQ
P
ER
G
A
L
----
L
P
LR
K
H
F
K
L
F
S
NLRP
AK
LYQG
L
EAF
CPL
R
A
D
I
A
A
NGF
D
ILC
VRE
L
T
G
GIY
F
GQPK
GR
EG
SG
-
Q
Y
EK
AF
DTE
V
Y
H
R
F
E
I
-----------------------
E
RI
A
R
I
AFE
S
A
RK
R
-
R
HK
VTS
ID
K
A
N
V
L
QS
S
I-L
W
R
E
I
V
NE
IA
T
EY
--------------------
P
DV
ELAHMY
ID
NATM
Q
L
I
KD
P
S
QFDV
L
L
CSNLFGDILSD
EC
A
M
I
TG
S
M
G
ML
PSA
S
LN
-
E
QG
F
-
G
L
Y
EP
A
G
GSAPDIAGKNIANPIA
Q
ILS
L
A
LL
LR
Y
S
L
DA
D
D
-
---
AA
SA
I
ER
AI
N
R
A
L
EE
G
IR
T
G
D
LA
R
---
GAA
AVS
T
N
E
M
GD
I
I
A
R
YVAEGV
fig|585056.7.peg.263
Escherichia coli UMN026
MSKN
YH
IA
V
L
PGDGIG
P
EV
M
T
QA
LKVLDA
V
R
N
R
F
---
AMR
I
T
TSHYDV
G
GAA
-
IDN
HGQ
P
--
LP
PA
T
V
E
GCE
Q
A
DA
VL
FG
S
VG
GPK
W
EHLP
PD
QQ
P
ER
G
A
L
----
L
P
LR
K
H
F
K
L
F
S
NLRP
AK
LYQG
L
EAF
CPL
R
A
D
I
A
A
NGF
D
ILC
VRE
L
T
G
GIY
F
GQPK
GR
EG
SG
-
Q
Y
EK
AF
DTE
V
Y
H
R
F
E
I
-----------------------
E
RI
A
R
I
AFE
S
A
RK
R
-
R
HK
VTS
ID
K
A
N
V
L
QS
S
I-L
W
R
E
I
V
NE
IA
T
EY
--------------------
P
DV
ELAHMY
ID
NATM
Q
L
I
KD
P
S
QFDV
L
L
CSNLFGDILSD
EC
A
M
I
TG
S
M
G
ML
PSA
S
LN
-
E
QG
F
-
G
L
Y
EP
A
G
GSAPDIAGKNIANPIA
Q
ILS
L
A
LL
LR
Y
S
L
DA
D
D
-
---
AA
SA
I
ER
AI
N
R
A
L
EE
G
IR
T
G
D
LA
R
---
GAA
AVS
T
N
E
M
GD
I
I
A
R
YVAEGV
fig|216592.1.peg.4337
Escherichia coli 042 (2-364/364)
MSKN
YH
IA
V
L
PGDGIG
P
EV
M
T
QA
LKVLDA
V
R
N
R
F
---
AMR
I
T
TSHYDV
G
GAA
-
IDN
HGQ
P
--
LP
PA
T
V
E
GCE
Q
A
DA
VL
FG
S
VG
GPK
W
EHLP
PD
QQ
P
ER
G
A
L
----
L
P
LR
K
H
F
K
L
F
S
NLRP
AK
LYQG
L
EAF
CPL
R
A
D
I
A
A
NGF
D
ILC
VRE
L
T
G
GIY
F
GQPK
GR
EG
SG
-
Q
Y
EK
AF
DTE
V
Y
H
R
F
E
I
-----------------------
E
RI
A
R
I
AFE
S
A
RK
R
-
R
HK
VTS
ID
K
A
N
V
L
QS
S
I-L
W
R
E
I
V
NE
IA
T
EY
--------------------
P
DV
ELAHMY
ID
NATM
Q
L
I
KD
P
S
QFDV
L
L
CSNLFGDILSD
EC
A
M
I
TG
S
M
G
ML
PSA
S
LN
-
E
QG
F
-
G
L
Y
EP
A
G
GSAPDIAGKNIANPIA
Q
ILS
L
A
LL
LR
Y
S
L
DA
D
D
-
---
AA
SA
I
EH
AI
N
R
A
L
EE
G
IR
T
G
D
LA
R
---
GAA
AVS
T
D
E
M
GD
I
I
A
R
YVAEGV
fig|216592.3.peg.84
Escherichia coli 042
MSKN
YH
IA
V
L
PGDGIG
P
EV
M
T
QA
LKVLDA
V
R
N
R
F
---
AMR
I
T
TSHYDV
G
GAA
-
IDN
HGQ
P
--
LP
PA
T
V
E
GCE
Q
A
DA
VL
FG
S
VG
GPK
W
EHLP
PD
QQ
P
ER
G
A
L
----
L
P
LR
K
H
F
K
L
F
S
NLRP
AK
LYQG
L
EAF
CPL
R
A
D
I
A
A
NGF
D
ILC
VRE
L
T
G
GIY
F
GQPK
GR
EG
SG
-
Q
Y
EK
AF
DTE
V
Y
H
R
F
E
I
-----------------------
E
RI
A
R
I
AFE
S
A
RK
R
-
R
HK
VTS
ID
K
A
N
V
L
QS
S
I-L
W
R
E
I
V
NE
IA
T
EY
--------------------
P
DV
ELAHMY
ID
NATM
Q
L
I
KD
P
S
QFDV
L
L
CSNLFGDILSD
EC
A
M
I
TG
S
M
G
ML
PSA
S
LN
-
E
QG
F
-
G
L
Y
EP
A
G
GSAPDIAGKNIANPIA
Q
ILS
L
A
LL
LR
Y
S
L
DA
D
D
-
---
AA
SA
I
EH
AI
N
R
A
L
EE
G
IR
T
G
D
LA
R
---
GAA
AVS
T
D
E
M
GD
I
I
A
R
YVAEGV
fig|656393.3.peg.687
Escherichia coli H299
MSKN
YH
IA
V
L
PGDGIG
P
EV
M
T
QA
LKVLDA
V
R
N
R
F
---
AMR
I
T
TSHYDV
G
GAA
-
IDN
HGQ
P
--
LP
PA
T
V
E
GCE
Q
A
DA
VL
FG
S
VG
GPK
W
EHLS
PD
QQ
P
ER
G
A
L
----
L
P
LR
K
H
F
K
L
F
S
NLRP
AK
LYQG
L
EAF
CPL
R
A
D
I
A
A
NGF
D
ILC
VRE
L
T
G
GIY
F
GQPK
GR
EG
SG
-
Q
Y
EK
AF
DTE
V
Y
H
R
F
E
I
-----------------------
E
RI
A
R
I
AFE
S
A
RK
R
-
R
HK
VTS
ID
K
A
N
V
L
QS
S
I-L
W
R
E
I
V
NE
IA
T
EY
--------------------
P
DV
ELAHMY
ID
NATM
Q
L
I
KD
P
S
QFDV
L
L
CSNLFGDILSD
EC
A
M
I
TG
S
M
G
ML
PSA
S
LN
-
E
QG
F
-
G
L
Y
EP
A
G
GSAPDIAGKNIANPIA
Q
ILS
L
A
LL
LR
Y
S
L
DA
D
D
-
---
AA
CA
I
ER
AI
N
R
A
L
EE
G
IR
T
G
D
LA
R
---
GAA
AVS
T
N
E
M
GD
I
I
A
R
YV
V
EGV
fig|749531.3.peg.4542
Escherichia coli MS 69-1
MSKN
YH
IA
V
L
PGDGIG
P
EV
M
T
QA
LKVLDA
V
R
N
R
F
---
AMR
I
T
TSHYDV
G
GAA
-
IDN
HGQ
P
--
LP
PA
T
V
E
GCE
Q
A
DA
VL
FG
S
VG
GPK
W
EHLP
PD
QQ
P
ER
G
A
L
----
L
P
LR
K
H
F
K
L
F
S
NLRP
AK
LYQG
L
EAF
CPL
R
A
D
I
A
A
NGF
D
ILC
VRE
L
T
G
GIY
F
GQPK
GR
EG
SG
-
Q
Y
EK
AF
DTE
V
Y
H
R
F
E
I
-----------------------
E
RI
A
R
I
AFE
S
A
RK
R
-
R
HK
VTS
ID
K
A
N
V
L
QS
S
I-L
W
R
E
I
V
NE
IA
T
EY
--------------------
P
DV
ELAHMY
ID
NATM
Q
L
I
KD
P
S
QFDV
L
L
CSNLFGDILSD
EC
A
M
I
TG
S
M
G
ML
PSA
S
LN
-
E
QG
F
-
G
L
Y
EP
A
G
GSAPDIAGKNIANPIA
Q
ILS
L
A
LL
LR
Y
S
L
DA
D
D
-
---
AA
SA
I
ER
AI
N
R
A
L
EE
G
IR
T
G
D
LA
R
---
GAA
AVS
T
N
E
M
GD
I
I
A
R
YV
V
EGV
fig|439855.10.peg.254
Escherichia coli SMS-3-5
MSKN
YH
IA
V
L
PGDGIG
P
EV
M
T
QA
LKVLDA
V
R
N
R
F
---
AMR
I
T
TSHYDV
G
GAA
-
IDN
HGQ
P
--
LP
PA
T
V
E
GCE
Q
A
DA
VL
FG
S
VG
GPK
W
EHLP
PD
QQ
P
ER
G
A
L
----
L
P
LR
K
H
F
K
L
F
S
NLRP
AK
LYQG
L
EAF
CPL
R
A
D
I
A
A
NGF
D
ILC
VRE
L
T
G
GIY
F
GQPK
GR
EG
SG
-
Q
Y
EK
AF
DTE
V
Y
H
R
F
E
I
-----------------------
E
RI
A
R
I
AFE
S
A
RK
R
-
R
HK
VTS
ID
K
A
N
V
L
QS
S
I-L
W
R
E
I
V
NE
IA
T
EY
--------------------
P
DV
ELAHMY
ID
NATM
Q
L
I
KD
P
S
QFDV
L
L
CSNLFGDILSD
EC
A
M
I
TG
S
M
G
ML
PSA
S
LN
-
E
QG
F
-
G
L
Y
EP
A
G
GSAPDIAGKNIANPIA
Q
ILS
L
A
LL
LR
Y
S
L
DA
D
D
-
---
AA
SA
I
ER
AI
N
R
A
L
EE
G
IR
T
G
D
LA
R
---
GAA
AVS
T
N
E
M
GD
I
I
A
R
YV
V
EGV
fig|362663.8.peg.81
Escherichia coli 536
MSKN
YH
IA
V
L
PGDGIG
P
EV
M
T
QA
LKVLDA
V
R
N
R
F
---
AMR
I
T
TSHYDV
G
GAA
-
IDN
HGQ
P
--
LP
TA
T
V
E
GCE
Q
A
DA
VL
FG
S
VG
GPK
W
EHLP
PD
QQ
P
ER
G
A
L
----
L
P
LR
K
H
F
K
L
F
S
NLRP
AK
LYQG
L
EAF
CPL
R
A
D
I
A
A
NGF
D
ILC
VRE
L
T
G
GIY
F
GQPK
GR
EG
SG
-
Q
Y
EK
AF
DTE
V
Y
H
R
F
E
I
-----------------------
E
RI
A
R
I
AFE
S
A
RK
R
-
R
HK
VTS
ID
K
A
N
V
L
QS
S
I-L
W
R
E
I
V
NE
IA
T
EY
--------------------
P
DV
ELTHMY
ID
NATM
Q
L
I
KD
P
S
QFDV
L
L
CSNLFGDILSD
EC
A
M
I
TG
S
M
G
ML
PSA
S
LN
-
E
QG
F
-
G
L
Y
EP
A
G
GSAPDIAGKNIANPIA
Q
ILS
L
A
LL
LR
Y
S
L
DA
D
D
-
---
AA
SA
I
ER
AI
N
R
A
L
EE
G
IR
T
G
D
LA
R
---
GAA
AVS
T
D
E
M
GD
I
I
A
R
YVAEGV
fig|362663.9.peg.81
Escherichia coli 536
MSKN
YH
IA
V
L
PGDGIG
P
EV
M
T
QA
LKVLDA
V
R
N
R
F
---
AMR
I
T
TSHYDV
G
GAA
-
IDN
HGQ
P
--
LP
TA
T
V
E
GCE
Q
A
DA
VL
FG
S
VG
GPK
W
EHLP
PD
QQ
P
ER
G
A
L
----
L
P
LR
K
H
F
K
L
F
S
NLRP
AK
LYQG
L
EAF
CPL
R
A
D
I
A
A
NGF
D
ILC
VRE
L
T
G
GIY
F
GQPK
GR
EG
SG
-
Q
Y
EK
AF
DTE
V
Y
H
R
F
E
I
-----------------------
E
RI
A
R
I
AFE
S
A
RK
R
-
R
HK
VTS
ID
K
A
N
V
L
QS
S
I-L
W
R
E
I
V
NE
IA
T
EY
--------------------
P
DV
ELTHMY
ID
NATM
Q
L
I
KD
P
S
QFDV
L
L
CSNLFGDILSD
EC
A
M
I
TG
S
M
G
ML
PSA
S
LN
-
E
QG
F
-
G
L
Y
EP
A
G
GSAPDIAGKNIANPIA
Q
ILS
L
A
LL
LR
Y
S
L
DA
D
D
-
---
AA
SA
I
ER
AI
N
R
A
L
EE
G
IR
T
G
D
LA
R
---
GAA
AVS
T
D
E
M
GD
I
I
A
R
YVAEGV
fig|340197.3.peg.4336
Escherichia coli F11
MSKN
YH
IA
V
L
PGDGIG
P
EV
M
T
QA
LKVLDA
V
R
N
R
F
---
AMR
I
T
TSHYDV
G
GAA
-
IDN
HGQ
P
--
LP
TA
T
V
E
GCE
Q
A
DA
VL
FG
S
VG
GPK
W
EHLP
PD
QQ
P
ER
G
A
L
----
L
P
LR
K
H
F
K
L
F
S
NLRP
AK
LYQG
L
EAF
CPL
R
A
D
I
A
A
NGF
D
ILC
VRE
L
T
G
GIY
F
GQPK
GR
EG
SG
-
Q
Y
EK
AF
DTE
V
Y
H
R
F
E
I
-----------------------
E
RI
A
R
I
AFE
S
A
RK
R
-
R
HK
VTS
ID
K
A
N
V
L
QS
S
I-L
W
R
E
I
V
NE
IA
T
EY
--------------------
P
DV
ELTHMY
ID
NATM
Q
L
I
KD
P
S
QFDV
L
L
CSNLFGDILSD
EC
A
M
I
TG
S
M
G
ML
PSA
S
LN
-
E
QG
F
-
G
L
Y
EP
A
G
GSAPDIAGKNIANPIA
Q
ILS
L
A
LL
LR
Y
S
L
DA
D
D
-
---
AA
SA
I
ER
AI
N
R
A
L
EE
G
IR
T
G
D
LA
R
---
GAA
AVS
T
D
E
M
GD
I
I
A
R
YVAEGV
fig|340197.5.peg.4529
Escherichia coli F11
MSKN
YH
IA
V
L
PGDGIG
P
EV
M
T
QA
LKVLDA
V
R
N
R
F
---
AMR
I
T
TSHYDV
G
GAA
-
IDN
HGQ
P
--
LP
TA
T
V
E
GCE
Q
A
DA
VL
FG
S
VG
GPK
W
EHLP
PD
QQ
P
ER
G
A
L
----
L
P
LR
K
H
F
K
L
F
S
NLRP
AK
LYQG
L
EAF
CPL
R
A
D
I
A
A
NGF
D
ILC
VRE
L
T
G
GIY
F
GQPK
GR
EG
SG
-
Q
Y
EK
AF
DTE
V
Y
H
R
F
E
I
-----------------------
E
RI
A
R
I
AFE
S
A
RK
R
-
R
HK
VTS
ID
K
A
N
V
L
QS
S
I-L
W
R
E
I
V
NE
IA
T
EY
--------------------
P
DV
ELTHMY
ID
NATM
Q
L
I
KD
P
S
QFDV
L
L
CSNLFGDILSD
EC
A
M
I
TG
S
M
G
ML
PSA
S
LN
-
E
QG
F
-
G
L
Y
EP
A
G
GSAPDIAGKNIANPIA
Q
ILS
L
A
LL
LR
Y
S
L
DA
D
D
-
---
AA
SA
I
ER
AI
N
R
A
L
EE
G
IR
T
G
D
LA
R
---
GAA
AVS
T
D
E
M
GD
I
I
A
R
YVAEGV
fig|749550.3.peg.2591
Escherichia coli MS 200-1
MSKN
YH
IA
V
L
PGDGIG
P
EV
M
T
QA
LKVLDA
V
R
N
R
F
---
AMR
I
T
TSHYDV
G
GAA
-
IDN
HGQ
P
--
LP
TA
T
V
E
GCE
Q
A
DA
VL
FG
S
VG
GPK
W
EHLP
PD
QQ
P
ER
G
A
L
----
L
P
LR
K
H
F
K
L
F
S
NLRP
AK
LYQG
L
EAF
CPL
R
A
D
I
A
A
NGF
D
ILC
VRE
L
T
G
GIY
F
GQPK
GR
EG
SG
-
Q
Y
EK
AF
DTE
V
Y
H
R
F
E
I
-----------------------
E
RI
A
R
I
AFE
S
A
RK
R
-
R
HK
VTS
ID
K
A
N
V
L
QS
S
I-L
W
R
E
I
V
NE
IA
T
EY
--------------------
P
DV
ELTHMY
ID
NATM
Q
L
I
KD
P
S
QFDV
L
L
CSNLFGDILSD
EC
A
M
I
TG
S
M
G
ML
PSA
S
LN
-
E
QG
F
-
G
L
Y
EP
A
G
GSAPDIAGKNIANPIA
Q
ILS
L
A
LL
LR
Y
S
L
DA
D
D
-
---
AA
SA
I
ER
AI
N
R
A
L
EE
G
IR
T
G
D
LA
R
---
GAA
AVS
T
D
E
M
GD
I
I
A
R
YVAEGV
fig|656437.3.peg.133
Escherichia coli TA143
MSKN
YH
IA
V
L
PGDGIG
P
EV
M
T
QA
LKVLDA
V
R
N
R
F
---
TMR
I
T
TSHYDV
G
GAA
-
IDN
HGQ
P
--
LP
PA
T
I
E
GCE
Q
A
DA
VL
FG
S
VG
GPK
W
EHLP
PD
QQ
P
ER
G
A
L
----
L
P
LR
KQ
F
K
L
F
S
NLRP
AK
LYQG
L
EAF
CPL
R
A
D
I
A
A
NGF
D
ILC
VRE
L
T
G
GIY
F
GQPK
GR
EG
SG
-
Q
Y
EK
AF
DTE
V
Y
H
R
F
E
I
-----------------------
E
RI
A
R
I
AFE
S
A
RK
R
-
R
HK
VTS
ID
K
A
N
V
L
QS
S
I-L
W
R
E
I
V
NE
IA
T
EY
--------------------
P
DV
ELAHMY
ID
NATM
Q
L
I
KD
P
S
QFDV
L
L
CSNLFGDILSD
EC
A
M
I
TG
S
M
G
ML
PSA
S
LN
-
E
QG
F
-
G
L
Y
EP
A
G
GSAPDIAGKNIANPIA
Q
ILS
L
A
LL
LR
Y
S
L
DA
D
D
-
---
AA
SA
I
ER
AI
N
R
A
L
EE
G
IR
T
G
D
LA
R
---
GAA
AVS
T
N
E
M
GD
I
I
A
R
YVAEGV
fig|656437.3.peg.2038
Escherichia coli TA143 (1-359/361)
M
M
K
T
MR
IA
A
IPGDGIG
K
EV
L
P
EG
IR
VL
Q
AA
A
ER
W
---
GFA
L
S
FEQMEW
A
SCE
Y
YSH
HG
K
M
--
M
P
DD
W
H
E
QLS
R
F
DA
IY
FG
A
VG
---
W
PDTV
PD
HI
S
LW
G
S
L
----
L
K
F
R
R
EFD
Q
Y
V
NLRPVRL
FP
G
V
P
--
CPL
-
A
G
K
Q
P
GGI
D
FYV
VRENTEG
E
Y
-
SSLG
GR
VN
E
G
T
E
H
E
V
VI
QES
VF
T
R
R
G
V
-----------------------
D
RI
L
R
Y
AFE
L
A
QS
R
P
R
KT
L
TS
AT
K
S
N
G
L
AI
S
MPY
W
D
E
R
V
EA
M
A
E
N
Y
--------------------
PEI
CWDKQH
ID
ILCA
R
F
V
MQ
P
E
R
FDV
V
V
A
SNLFGDILSD
LG
P
A
C
TG
T
IGIAPSANLN
P
E
RT
F
P
S
LFEP
V
HGSAPDI
Y
GKNIANPIA
T
I
WA
G
AMML
D
F
L
G
NG
D
E
R
FQQ
A
H
NG
I
LA
AIE
E
V
I
AH
G
PK
T
P
D
M-
K
---
G
S
A
--T
T
P
Q
V
A
DAI
C
K
II
fig|216592.1.peg.1349
Escherichia coli 042 (1-359/361)
M
M
K
T
MR
IA
A
IPGDGIG
K
EV
L
P
EG
IR
VL
Q
AA
A
ER
W
---
GFA
L
S
FEQMEW
A
SCE
Y
YSH
HG
K
M
--
M
P
DD
W
H
E
QLS
R
F
DA
IY
FG
A
VG
---
W
PDTV
PD
HI
S
LW
G
S
L
----
L
K
F
R
R
EFD
Q
Y
V
NLRPVRL
FP
G
V
P
--
CPL
-
A
G
K
Q
P
GDI
D
FYV
VRENTEG
E
Y
-
SSLG
GR
VN
E
G
T
E
H
E
V
VI
QES
VF
T
R
R
G
V
-----------------------
D
RI
L
R
Y
AFE
L
A
QS
R
P
R
KT
L
TS
AT
K
S
N
G
L
AI
S
MPY
W
D
E
R
V
EA
M
A
E
N
Y
--------------------
PEI
RWDKQH
ID
ILCA
R
F
V
MQ
P
E
R
FDV
V
V
A
SNLFGDILSD
LG
P
A
C
TG
T
IGIAPSANLN
P
E
RT
F
P
S
LFEP
V
HGSAPDI
Y
GKNIANPIA
T
I
WA
G
AMML
D
F
L
G
NG
D
E
R
FHQ
A
H
NG
I
LA
AIE
E
V
I
AH
G
PK
T
P
D
M-
K
---
G
S
A
--T
T
P
Q
V
A
DAI
C
K
II
fig|216592.3.peg.2046
Escherichia coli 042 (1-359/361)
M
M
K
T
MR
IA
A
IPGDGIG
K
EV
L
P
EG
IR
VL
Q
AA
A
ER
W
---
GFA
L
S
FEQMEW
A
SCE
Y
YSH
HG
K
M
--
M
P
DD
W
H
E
QLS
R
F
DA
IY
FG
A
VG
---
W
PDTV
PD
HI
S
LW
G
S
L
----
L
K
F
R
R
EFD
Q
Y
V
NLRPVRL
FP
G
V
P
--
CPL
-
A
G
K
Q
P
GDI
D
FYV
VRENTEG
E
Y
-
SSLG
GR
VN
E
G
T
E
H
E
V
VI
QES
VF
T
R
R
G
V
-----------------------
D
RI
L
R
Y
AFE
L
A
QS
R
P
R
KT
L
TS
AT
K
S
N
G
L
AI
S
MPY
W
D
E
R
V
EA
M
A
E
N
Y
--------------------
PEI
RWDKQH
ID
ILCA
R
F
V
MQ
P
E
R
FDV
V
V
A
SNLFGDILSD
LG
P
A
C
TG
T
IGIAPSANLN
P
E
RT
F
P
S
LFEP
V
HGSAPDI
Y
GKNIANPIA
T
I
WA
G
AMML
D
F
L
G
NG
D
E
R
FHQ
A
H
NG
I
LA
AIE
E
V
I
AH
G
PK
T
P
D
M-
K
---
G
S
A
--T
T
P
Q
V
A
DAI
C
K
II
fig|562.371.peg.4668
Escherichia coli 1044A (1-359/361)
M
M
K
T
MR
IA
A
IPGDGIG
K
EV
L
P
EG
IR
VL
Q
AA
A
ER
W
---
GFA
L
S
FEQMEW
A
SCE
Y
YSH
HG
K
M
--
M
P
DD
W
H
E
QLS
R
F
DA
IY
FG
A
VG
---
W
PDTV
PD
HI
S
LW
G
S
L
----
L
K
F
R
R
EFD
Q
Y
V
NLRPVRL
FP
G
V
P
--
CPL
-
A
G
K
Q
P
GDI
D
FYV
VRENTEG
E
Y
-
SSLG
GR
VN
E
G
T
E
H
E
V
VI
QES
VF
T
R
R
G
V
-----------------------
D
RI
L
R
Y
AFE
L
A
QS
R
P
R
KT
L
TS
AT
K
S
N
G
L
AI
S
MPY
W
D
E
R
V
EA
M
A
E
N
Y
--------------------
PEI
RWDKQH
ID
ILCA
R
F
V
MQ
P
E
R
FDV
V
V
A
SNLFGDILSD
LG
P
A
C
TG
T
IGIAPSANLN
P
E
RT
F
P
S
LFEP
V
HGSAPDI
Y
GKNIANPIA
T
I
WA
G
AMML
D
F
L
G
NG
D
E
R
FQQ
A
H
NG
I
LA
AIE
E
V
I
AH
G
PK
T
P
D
M-
K
---
G
S
A
--T
T
P
Q
V
A
DAI
C
K
II
fig|562.373.peg.5567
Escherichia coli 1125A (1-359/361)
M
M
K
T
MR
IA
A
IPGDGIG
K
EV
L
P
EG
IR
VL
Q
AA
A
ER
W
---
GFA
L
S
FEQMEW
A
SCE
Y
YSH
HG
K
M
--
M
P
DD
W
H
E
QLS
R
F
DA
IY
FG
A
VG
---
W
PDTV
PD
HI
S
LW
G
S
L
----
L
K
F
R
R
EFD
Q
Y
V
NLRPVRL
FP
G
V
P
--
CPL
-
A
G
K
Q
P
GDI
D
FYV
VRENTEG
E
Y
-
SSLG
GR
VN
E
G
T
E
H
E
V
VI
QES
VF
T
R
R
G
V
-----------------------
D
RI
L
R
Y
AFE
L
A
QS
R
P
R
KT
L
TS
AT
K
S
N
G
L
AI
S
MPY
W
D
E
R
V
EA
M
A
E
N
Y
--------------------
PEI
RWDKQH
ID
ILCA
R
F
V
MQ
P
E
R
FDV
V
V
A
SNLFGDILSD
LG
P
A
C
TG
T
IGIAPSANLN
P
E
RT
F
P
S
LFEP
V
HGSAPDI
Y
GKNIANPIA
T
I
WA
G
AMML
D
F
L
G
NG
D
E
R
FQQ
A
H
NG
I
LA
AIE
E
V
I
AH
G
PK
T
P
D
M-
K
---
G
S
A
--T
T
P
Q
V
A
DAI
C
K
II
fig|562.372.peg.4899
Escherichia coli 1212A (1-359/361)
M
M
K
T
MR
IA
A
IPGDGIG
K
EV
L
P
EG
IR
VL
Q
AA
A
ER
W
---
GFA
L
S
FEQMEW
A
SCE
Y
YSH
HG
K
M
--
M
P
DD
W
H
E
QLS
R
F
DA
IY
FG
A
VG
---
W
PDTV
PD
HI
S
LW
G
S
L
----
L
K
F
R
R
EFD
Q
Y
V
NLRPVRL
FP
G
V
P
--
CPL
-
A
G
K
Q
P
GDI
D
FYV
VRENTEG
E
Y
-
SSLG
GR
VN
E
G
T
E
H
E
V
VI
QES
VF
T
R
R
G
V
-----------------------
D
RI
L
R
Y
AFE
L
A
QS
R
P
R
KT
L
TS
AT
K
S
N
G
L
AI
S
MPY
W
D
E
R
V
EA
M
A
E
N
Y
--------------------
PEI
RWDKQH
ID
ILCA
R
F
V
MQ
P
E
R
FDV
V
V
A
SNLFGDILSD
LG
P
A
C
TG
T
IGIAPSANLN
P
E
RT
F
P
S
LFEP
V
HGSAPDI
Y
GKNIANPIA
T
I
WA
G
AMML
D
F
L
G
NG
D
E
R
FQQ
A
H
NG
I
LA
AIE
E
V
I
AH
G
PK
T
P
D
M-
K
---
G
S
A
--T
T
P
Q
V
A
DAI
C
K
II
fig|562.374.peg.4212
Escherichia coli 536A (1-359/361)
M
M
K
T
MR
IA
A
IPGDGIG
K
EV
L
P
EG
IR
VL
Q
AA
A
ER
W
---
GFA
L
S
FEQMEW
A
SCE
Y
YSH
HG
K
M
--
M
P
DD
W
H
E
QLS
R
F
DA
IY
FG
A
VG
---
W
PDTV
PD
HI
S
LW
G
S
L
----
L
K
F
R
R
EFD
Q
Y
V
NLRPVRL
FP
G
V
P
--
CPL
-
A
G
K
Q
P
GDI
D
FYV
VRENTEG
E
Y
-
SSLG
GR
VN
E
G
T
E
H
E
V
VI
QES
VF
T
R
R
G
V
-----------------------
D
RI
L
R
Y
AFE
L
A
QS
R
P
R
KT
L
TS
AT
K
S
N
G
L
AI
S
MPY
W
D
E
R
V
EA
M
A
E
N
Y
--------------------
PEI
RWDKQH
ID
ILCA
R
F
V
MQ
P
E
R
FDV
V
V
A
SNLFGDILSD
LG
P
A
C
TG
T
IGIAPSANLN
P
E
RT
F
P
S
LFEP
V
HGSAPDI
Y
GKNIANPIA
T
I
WA
G
AMML
D
F
L
G
NG
D
E
R
FQQ
A
H
NG
I
LA
AIE
E
V
I
AH
G
PK
T
P
D
M-
K
---
G
S
A
--T
T
P
Q
V
A
DAI
C
K
II
fig|550676.3.peg.2116
Escherichia coli B185 (1-359/361)
M
M
K
T
MR
IA
A
IPGDGIG
K
EV
L
P
EG
IR
VL
Q
AA
A
ER
W
---
GFA
L
S
FEQMEW
A
SCE
Y
YSH
HG
K
M
--
M
P
DD
W
H
E
QLS
R
F
DA
IY
FG
A
VG
---
W
PDTV
PD
HI
S
LW
G
S
L
----
L
K
F
R
R
EFD
Q
Y
V
NLRPVRL
FP
G
V
P
--
CPL
-
A
G
K
Q
P
GDI
D
FYV
VRENTEG
E
Y
-
SSLG
GR
VN
E
G
T
E
H
E
V
VI
QES
VF
T
R
R
G
V
-----------------------
D
RI
L
R
Y
AFE
L
A
QS
R
P
R
KT
L
TS
AT
K
S
N
G
L
AI
S
MPY
W
D
E
R
V
EA
M
A
E
N
Y
--------------------
PEI
RWDKQH
ID
ILCA
R
F
V
MQ
P
E
R
FDV
V
V
A
SNLFGDILSD
LG
P
A
C
TG
T
IGIAPSANLN
P
E
RT
F
P
S
LFEP
V
HGSAPDI
Y
GKNIANPIA
T
I
WA
G
AMML
D
F
L
G
NG
D
E
R
FQQ
A
H
NG
I
LA
AIE
E
V
I
AH
G
PK
T
P
D
M-
K
---
G
S
A
--T
T
P
Q
V
A
DAI
C
K
II
fig|656419.3.peg.2523
Escherichia coli M718 (1-359/361)
M
M
K
T
MR
IA
A
IPGDGIG
K
EV
L
P
EG
IR
VL
Q
AA
A
ER
W
---
GFA
L
S
FEQMEW
A
SCE
Y
YSH
HG
K
M
--
M
P
DD
W
H
E
QLS
R
F
DA
IY
FG
A
VG
---
W
PDTV
PD
HI
S
LW
G
S
L
----
L
K
F
R
R
EFD
Q
Y
V
NLRPVRL
FP
G
V
P
--
CPL
-
A
G
K
Q
P
GDI
D
FYV
VRENTEG
E
Y
-
SSLG
GR
VN
E
G
T
E
H
E
V
VI
QES
VF
T
R
R
G
V
-----------------------
D
RI
L
R
Y
AFE
L
A
QS
R
P
R
KT
L
TS
AT
K
S
N
G
L
AI
S
MPY
W
D
E
R
V
EA
M
A
E
N
Y
--------------------
PEI
RWDKQH
ID
ILCA
R
F
V
MQ
P
E
R
FDV
V
V
A
SNLFGDILSD
LG
P
A
C
TG
T
IGIAPSANLN
P
E
RT
F
P
S
LFEP
V
HGSAPDI
Y
GKNIANPIA
T
I
WA
G
AMML
D
F
L
G
NG
D
E
R
FQQ
A
H
NG
I
LA
AIE
E
V
I
AH
G
PK
T
P
D
M-
K
---
G
S
A
--T
T
P
Q
V
A
DAI
C
K
II
fig|83334.1.peg.2535
Escherichia coli O157:H7 (1-359/361)
M
M
K
T
MR
IA
A
IPGDGIG
K
EV
L
P
EG
IR
VL
Q
AA
A
ER
W
---
GFA
L
S
FEQMEW
A
SCE
Y
YSH
HG
K
M
--
M
P
DD
W
H
E
QLS
R
F
DA
IY
FG
A
VG
---
W
PDTV
PD
HI
S
LW
G
S
L
----
L
K
F
R
R
EFD
Q
Y
V
NLRPVRL
FP
G
V
P
--
CPL
-
A
G
K
Q
P
GDI
D
FYV
VRENTEG
E
Y
-
SSLG
GR
VN
E
G
T
E
H
E
V
VI
QES
VF
T
R
R
G
V
-----------------------
D
RI
L
R
Y
AFE
L
A
QS
R
P
R
KT
L
TS
AT
K
S
N
G
L
AI
S
MPY
W
D
E
R
V
EA
M
A
E
N
Y
--------------------
PEI
RWDKQH
ID
ILCA
R
F
V
MQ
P
E
R
FDV
V
V
A
SNLFGDILSD
LG
P
A
C
TG
T
IGIAPSANLN
P
E
RT
F
P
S
LFEP
V
HGSAPDI
Y
GKNIANPIA
T
I
WA
G
AMML
D
F
L
G
NG
D
E
R
FQQ
A
H
NG
I
LA
AIE
E
V
I
AH
G
PK
T
P
D
M-
K
---
G
S
A
--T
T
P
Q
V
A
DAI
C
K
II
fig|155864.1.peg.2544
Escherichia coli O157:H7 EDL933 (1-359/361)
M
M
K
T
MR
IA
A
IPGDGIG
K
EV
L
P
EG
IR
VL
Q
AA
A
ER
W
---
GFA
L
S
FEQMEW
A
SCE
Y
YSH
HG
K
M
--
M
P
DD
W
H
E
QLS
R
F
DA
IY
FG
A
VG
---
W
PDTV
PD
HI
S
LW
G
S
L
----
L
K
F
R
R
EFD
Q
Y
V
NLRPVRL
FP
G
V
P
--
CPL
-
A
G
K
Q
P
GDI
D
FYV
VRENTEG
E
Y
-
SSLG
GR
VN
E
G
T
E
H
E
V
VI
QES
VF
T
R
R
G
V
-----------------------
D
RI
L
R
Y
AFE
L
A
QS
R
P
R
KT
L
TS
AT
K
S
N
G
L
AI
S
MPY
W
D
E
R
V
EA
M
A
E
N
Y
--------------------
PEI
RWDKQH
ID
ILCA
R
F
V
MQ
P
E
R
FDV
V
V
A
SNLFGDILSD
LG
P
A
C
TG
T
IGIAPSANLN
P
E
RT
F
P
S
LFEP
V
HGSAPDI
Y
GKNIANPIA
T
I
WA
G
AMML
D
F
L
G
NG
D
E
R
FQQ
A
H
NG
I
LA
AIE
E
V
I
AH
G
PK
T
P
D
M-
K
---
G
S
A
--T
T
P
Q
V
A
DAI
C
K
II
fig|155864.8.peg.2401
Escherichia coli O157:H7 EDL933 (1-359/361)
M
M
K
T
MR
IA
A
IPGDGIG
K
EV
L
P
EG
IR
VL
Q
AA
A
ER
W
---
GFA
L
S
FEQMEW
A
SCE
Y
YSH
HG
K
M
--
M
P
DD
W
H
E
QLS
R
F
DA
IY
FG
A
VG
---
W
PDTV
PD
HI
S
LW
G
S
L
----
L
K
F
R
R
EFD
Q
Y
V
NLRPVRL
FP
G
V
P
--
CPL
-
A
G
K
Q
P
GDI
D
FYV
VRENTEG
E
Y
-
SSLG
GR
VN
E
G
T
E
H
E
V
VI
QES
VF
T
R
R
G
V
-----------------------
D
RI
L
R
Y
AFE
L
A
QS
R
P
R
KT
L
TS
AT
K
S
N
G
L
AI
S
MPY
W
D
E
R
V
EA
M
A
E
N
Y
--------------------
PEI
RWDKQH
ID
ILCA
R
F
V
MQ
P
E
R
FDV
V
V
A
SNLFGDILSD
LG
P
A
C
TG
T
IGIAPSANLN
P
E
RT
F
P
S
LFEP
V
HGSAPDI
Y
GKNIANPIA
T
I
WA
G
AMML
D
F
L
G
NG
D
E
R
FQQ
A
H
NG
I
LA
AIE
E
V
I
AH
G
PK
T
P
D
M-
K
---
G
S
A
--T
T
P
Q
V
A
DAI
C
K
II
fig|444454.5.peg.1265
Escherichia coli O157:H7 str. EC4024 (1-359/361)
M
M
K
T
MR
IA
A
IPGDGIG
K
EV
L
P
EG
IR
VL
Q
AA
A
ER
W
---
GFA
L
S
FEQMEW
A
SCE
Y
YSH
HG
K
M
--
M
P
DD
W
H
E
QLS
R
F
DA
IY
FG
A
VG
---
W
PDTV
PD
HI
S
LW
G
S
L
----
L
K
F
R
R
EFD
Q
Y
V
NLRPVRL
FP
G
V
P
--
CPL
-
A
G
K
Q
P
GDI
D
FYV
VRENTEG
E
Y
-
SSLG
GR
VN
E
G
T
E
H
E
V
VI
QES
VF
T
R
R
G
V
-----------------------
D
RI
L
R
Y
AFE
L
A
QS
R
P
R
KT
L
TS
AT
K
S
N
G
L
AI
S
MPY
W
D
E
R
V
EA
M
A
E
N
Y
--------------------
PEI
RWDKQH
ID
ILCA
R
F
V
MQ
P
E
R
FDV
V
V
A
SNLFGDILSD
LG
P
A
C
TG
T
IGIAPSANLN
P
E
RT
F
P
S
LFEP
V
HGSAPDI
Y
GKNIANPIA
T
I
WA
G
AMML
D
F
L
G
NG
D
E
R
FQQ
A
H
NG
I
LA
AIE
E
V
I
AH
G
PK
T
P
D
M-
K
---
G
S
A
--T
T
P
Q
V
A
DAI
C
K
II
fig|444449.5.peg.754
Escherichia coli O157:H7 str. EC4042 (1-359/361)
M
M
K
T
MR
IA
A
IPGDGIG
K
EV
L
P
EG
IR
VL
Q
AA
A
ER
W
---
GFA
L
S
FEQMEW
A
SCE
Y
YSH
HG
K
M
--
M
P
DD
W
H
E
QLS
R
F
DA
IY
FG
A
VG
---
W
PDTV
PD
HI
S
LW
G
S
L
----
L
K
F
R
R
EFD
Q
Y
V
NLRPVRL
FP
G
V
P
--
CPL
-
A
G
K
Q
P
GDI
D
FYV
VRENTEG
E
Y
-
SSLG
GR
VN
E
G
T
E
H
E
V
VI
QES
VF
T
R
R
G
V
-----------------------
D
RI
L
R
Y
AFE
L
A
QS
R
P
R
KT
L
TS
AT
K
S
N
G
L
AI
S
MPY
W
D
E
R
V
EA
M
A
E
N
Y
--------------------
PEI
RWDKQH
ID
ILCA
R
F
V
MQ
P
E
R
FDV
V
V
A
SNLFGDILSD
LG
P
A
C
TG
T
IGIAPSANLN
P
E
RT
F
P
S
LFEP
V
HGSAPDI
Y
GKNIANPIA
T
I
WA
G
AMML
D
F
L
G
NG
D
E
R
FQQ
A
H
NG
I
LA
AIE
E
V
I
AH
G
PK
T
P
D
M-
K
---
G
S
A
--T
T
P
Q
V
A
DAI
C
K
II
fig|444448.5.peg.5054
Escherichia coli O157:H7 str. EC4045 (1-359/361)
M
M
K
T
MR
IA
A
IPGDGIG
K
EV
L
P
EG
IR
VL
Q
AA
A
ER
W
---
GFA
L
S
FEQMEW
A
SCE
Y
YSH
HG
K
M
--
M
P
DD
W
H
E
QLS
R
F
DA
IY
FG
A
VG
---
W
PDTV
PD
HI
S
LW
G
S
L
----
L
K
F
R
R
EFD
Q
Y
V
NLRPVRL
FP
G
V
P
--
CPL
-
A
G
K
Q
P
GDI
D
FYV
VRENTEG
E
Y
-
SSLG
GR
VN
E
G
T
E
H
E
V
VI
QES
VF
T
R
R
G
V
-----------------------
D
RI
L
R
Y
AFE
L
A
QS
R
P
R
KT
L
TS
AT
K
S
N
G
L
AI
S
MPY
W
D
E
R
V
EA
M
A
E
N
Y
--------------------
PEI
RWDKQH
ID
ILCA
R
F
V
MQ
P
E
R
FDV
V
V
A
SNLFGDILSD
LG
P
A
C
TG
T
IGIAPSANLN
P
E
RT
F
P
S
LFEP
V
HGSAPDI
Y
GKNIANPIA
T
I
WA
G
AMML
D
F
L
G
NG
D
E
R
FQQ
A
H
NG
I
LA
AIE
E
V
I
AH
G
PK
T
P
D
M-
K
---
G
S
A
--T
T
P
Q
V
A
DAI
C
K
II
fig|444453.5.peg.3608
Escherichia coli O157:H7 str. EC4076 (1-359/361)
M
M
K
T
MR
IA
A
IPGDGIG
K
EV
L
P
EG
IR
VL
Q
AA
A
ER
W
---
GFA
L
S
FEQMEW
A
SCE
Y
YSH
HG
K
M
--
M
P
DD
W
H
E
QLS
R
F
DA
IY
FG
A
VG
---
W
PDTV
PD
HI
S
LW
G
S
L
----
L
K
F
R
R
EFD
Q
Y
V
NLRPVRL
FP
G
V
P
--
CPL
-
A
G
K
Q
P
GDI
D
FYV
VRENTEG
E
Y
-
SSLG
GR
VN
E
G
T
E
H
E
V
VI
QES
VF
T
R
R
G
V
-----------------------
D
RI
L
R
Y
AFE
L
A
QS
R
P
R
KT
L
TS
AT
K
S
N
G
L
AI
S
MPY
W
D
E
R
V
EA
M
A
E
N
Y
--------------------
PEI
RWDKQH
ID
ILCA
R
F
V
MQ
P
E
R
FDV
V
V
A
SNLFGDILSD
LG
P
A
C
TG
T
IGIAPSANLN
P
E
RT
F
P
S
LFEP
V
HGSAPDI
Y
GKNIANPIA
T
I
WA
G
AMML
D
F
L
G
NG
D
E
R
FQQ
A
H
NG
I
LA
AIE
E
V
I
AH
G
PK
T
P
D
M-
K
---
G
S
A
--T
T
P
Q
V
A
DAI
C
K
II
fig|444452.5.peg.2379
Escherichia coli O157:H7 str. EC4113 (1-359/361)
M
M
K
T
MR
IA
A
IPGDGIG
K
EV
L
P
EG
IR
VL
Q
AA
A
ER
W
---
GFA
L
S
FEQMEW
A
SCE
Y
YSH
HG
K
M
--
M
P
DD
W
H
E
QLS
R
F
DA
IY
FG
A
VG
---
W
PDTV
PD
HI
S
LW
G
S
L
----
L
K
F
R
R
EFD
Q
Y
V
NLRPVRL
FP
G
V
P
--
CPL
-
A
G
K
Q
P
GDI
D
FYV
VRENTEG
E
Y
-
SSLG
GR
VN
E
G
T
E
H
E
V
VI
QES
VF
T
R
R
G
V
-----------------------
D
RI
L
R
Y
AFE
L
A
QS
R
P
R
KT
L
TS
AT
K
S
N
G
L
AI
S
MPY
W
D
E
R
V
EA
M
A
E
N
Y
--------------------
PEI
RWDKQH
ID
ILCA
R
F
V
MQ
P
E
R
FDV
V
V
A
SNLFGDILSD
LG
P
A
C
TG
T
IGIAPSANLN
P
E
RT
F
P
S
LFEP
V
HGSAPDI
Y
GKNIANPIA
T
I
WA
G
AMML
D
F
L
G
NG
D
E
R
FQQ
A
H
NG
I
LA
AIE
E
V
I
AH
G
PK
T
P
D
M-
K
---
G
S
A
--T
T
P
Q
V
A
DAI
C
K
II
fig|444450.8.peg.2565
Escherichia coli O157:H7 str. EC4115 (1-359/361)
M
M
K
T
MR
IA
A
IPGDGIG
K
EV
L
P
EG
IR
VL
Q
AA
A
ER
W
---
GFA
L
S
FEQMEW
A
SCE
Y
YSH
HG
K
M
--
M
P
DD
W
H
E
QLS
R
F
DA
IY
FG
A
VG
---
W
PDTV
PD
HI
S
LW
G
S
L
----
L
K
F
R
R
EFD
Q
Y
V
NLRPVRL
FP
G
V
P
--
CPL
-
A
G
K
Q
P
GDI
D
FYV
VRENTEG
E
Y
-
SSLG
GR
VN
E
G
T
E
H
E
V
VI
QES
VF
T
R
R
G
V
-----------------------
D
RI
L
R
Y
AFE
L
A
QS
R
P
R
KT
L
TS
AT
K
S
N
G
L
AI
S
MPY
W
D
E
R
V
EA
M
A
E
N
Y
--------------------
PEI
RWDKQH
ID
ILCA
R
F
V
MQ
P
E
R
FDV
V
V
A
SNLFGDILSD
LG
P
A
C
TG
T
IGIAPSANLN
P
E
RT
F
P
S
LFEP
V
HGSAPDI
Y
GKNIANPIA
T
I
WA
G
AMML
D
F
L
G
NG
D
E
R
FQQ
A
H
NG
I
LA
AIE
E
V
I
AH
G
PK
T
P
D
M-
K
---
G
S
A
--T
T
P
Q
V
A
DAI
C
K
II
fig|444451.5.peg.2518
Escherichia coli O157:H7 str. EC4196 (1-359/361)
M
M
K
T
MR
IA
A
IPGDGIG
K
EV
L
P
EG
IR
VL
Q
AA
A
ER
W
---
GFA
L
S
FEQMEW
A
SCE
Y
YSH
HG
K
M
--
M
P
DD
W
H
E
QLS
R
F
DA
IY
FG
A
VG
---
W
PDTV
PD
HI
S
LW
G
S
L
----
L
K
F
R
R
EFD
Q
Y
V
NLRPVRL
FP
G
V
P
--
CPL
-
A
G
K
Q
P
GDI
D
FYV
VRENTEG
E
Y
-
SSLG
GR
VN
E
G
T
E
H
E
V
VI
QES
VF
T
R
R
G
V
-----------------------
D
RI
L
R
Y
AFE
L
A
QS
R
P
R
KT
L
TS
AT
K
S
N
G
L
AI
S
MPY
W
D
E
R
V
EA
M
A
E
N
Y
--------------------
PEI
RWDKQH
ID
ILCA
R
F
V
MQ
P
E
R
FDV
V
V
A
SNLFGDILSD
LG
P
A
C
TG
T
IGIAPSANLN
P
E
RT
F
P
S
LFEP
V
HGSAPDI
Y
GKNIANPIA
T
I
WA
G
AMML
D
F
L
G
NG
D
E
R
FQQ
A
H
NG
I
LA
AIE
E
V
I
AH
G
PK
T
P
D
M-
K
---
G
S
A
--T
T
P
Q
V
A
DAI
C
K
II
fig|444447.5.peg.4934
Escherichia coli O157:H7 str. EC4206 (1-359/361)
M
M
K
T
MR
IA
A
IPGDGIG
K
EV
L
P
EG
IR
VL
Q
AA
A
ER
W
---
GFA
L
S
FEQMEW
A
SCE
Y
YSH
HG
K
M
--
M
P
DD
W
H
E
QLS
R
F
DA
IY
FG
A
VG
---
W
PDTV
PD
HI
S
LW
G
S
L
----
L
K
F
R
R
EFD
Q
Y
V
NLRPVRL
FP
G
V
P
--
CPL
-
A
G
K
Q
P
GDI
D
FYV
VRENTEG
E
Y
-
SSLG
GR
VN
E
G
T
E
H
E
V
VI
QES
VF
T
R
R
G
V
-----------------------
D
RI
L
R
Y
AFE
L
A
QS
R
P
R
KT
L
TS
AT
K
S
N
G
L
AI
S
MPY
W
D
E
R
V
EA
M
A
E
N
Y
--------------------
PEI
RWDKQH
ID
ILCA
R
F
V
MQ
P
E
R
FDV
V
V
A
SNLFGDILSD
LG
P
A
C
TG
T
IGIAPSANLN
P
E
RT
F
P
S
LFEP
V
HGSAPDI
Y
GKNIANPIA
T
I
WA
G
AMML
D
F
L
G
NG
D
E
R
FQQ
A
H
NG
I
LA
AIE
E
V
I
AH
G
PK
T
P
D
M-
K
---
G
S
A
--T
T
P
Q
V
A
DAI
C
K
II
fig|478004.5.peg.4713
Escherichia coli O157:H7 str. EC4401 (1-359/361)
M
M
K
T
MR
IA
A
IPGDGIG
K
EV
L
P
EG
IR
VL
Q
AA
A
ER
W
---
GFA
L
S
FEQMEW
A
SCE
Y
YSH
HG
K
M
--
M
P
DD
W
H
E
QLS
R
F
DA
IY
FG
A
VG
---
W
PDTV
PD
HI
S
LW
G
S
L
----
L
K
F
R
R
EFD
Q
Y
V
NLRPVRL
FP
G
V
P
--
CPL
-
A
G
K
Q
P
GDI
D
FYV
VRENTEG
E
Y
-
SSLG
GR
VN
E
G
T
E
H
E
V
VI
QES
VF
T
R
R
G
V
-----------------------
D
RI
L
R
Y
AFE
L
A
QS
R
P
R
KT
L
TS
AT
K
S
N
G
L
AI
S
MPY
W
D
E
R
V
EA
M
A
E
N
Y
--------------------
PEI
RWDKQH
ID
ILCA
R
F
V
MQ
P
E
R
FDV
V
V
A
SNLFGDILSD
LG
P
A
C
TG
T
IGIAPSANLN
P
E
RT
F
P
S
LFEP
V
HGSAPDI
Y
GKNIANPIA
T
I
WA
G
AMML
D
F
L
G
NG
D
E
R
FQQ
A
H
NG
I
LA
AIE
E
V
I
AH
G
PK
T
P
D
M-
K
---
G
S
A
--T
T
P
Q
V
A
DAI
C
K
II
fig|478005.5.peg.4490
Escherichia coli O157:H7 str. EC4486 (1-359/361)
M
M
K
T
MR
IA
A
IPGDGIG
K
EV
L
P
EG
IR
VL
Q
AA
A
ER
W
---
GFA
L
S
FEQMEW
A
SCE
Y
YSH
HG
K
M
--
M
P
DD
W
H
E
QLS
R
F
DA
IY
FG
A
VG
---
W
PDTV
PD
HI
S
LW
G
S
L
----
L
K
F
R
R
EFD
Q
Y
V
NLRPVRL
FP
G
V
P
--
CPL
-
A
G
K
Q
P
GDI
D
FYV
VRENTEG
E
Y
-
SSLG
GR
VN
E
G
T
E
H
E
V
VI
QES
VF
T
R
R
G
V
-----------------------
D
RI
L
R
Y
AFE
L
A
QS
R
P
R
KT
L
TS
AT
K
S
N
G
L
AI
S
MPY
W
D
E
R
V
EA
M
A
E
N
Y
--------------------
PEI
RWDKQH
ID
ILCA
R
F
V
MQ
P
E
R
FDV
V
V
A
SNLFGDILSD
LG
P
A
C
TG
T
IGIAPSANLN
P
E
RT
F
P
S
LFEP
V
HGSAPDI
Y
GKNIANPIA
T
I
WA
G
AMML
D
F
L
G
NG
D
E
R
FQQ
A
H
NG
I
LA
AIE
E
V
I
AH
G
PK
T
P
D
M-
K
---
G
S
A
--T
T
P
Q
V
A
DAI
C
K
II
fig|478006.5.peg.4575
Escherichia coli O157:H7 str. EC4501 (1-359/361)
M
M
K
T
MR
IA
A
IPGDGIG
K
EV
L
P
EG
IR
VL
Q
AA
A
ER
W
---
GFA
L
S
FEQMEW
A
SCE
Y
YSH
HG
K
M
--
M
P
DD
W
H
E
QLS
R
F
DA
IY
FG
A
VG
---
W
PDTV
PD
HI
S
LW
G
S
L
----
L
K
F
R
R
EFD
Q
Y
V
NLRPVRL
FP
G
V
P
--
CPL
-
A
G
K
Q
P
GDI
D
FYV
VRENTEG
E
Y
-
SSLG
GR
VN
E
G
T
E
H
E
V
VI
QES
VF
T
R
R
G
V
-----------------------
D
RI
L
R
Y
AFE
L
A
QS
R
P
R
KT
L
TS
AT
K
S
N
G
L
AI
S
MPY
W
D
E
R
V
EA
M
A
E
N
Y
--------------------
PEI
RWDKQH
ID
ILCA
R
F
V
MQ
P
E
R
FDV
V
V
A
SNLFGDILSD
LG
P
A
C
TG
T
IGIAPSANLN
P
E
RT
F
P
S
LFEP
V
HGSAPDI
Y
GKNIANPIA
T
I
WA
G
AMML
D
F
L
G
NG
D
E
R
FQQ
A
H
NG
I
LA
AIE
E
V
I
AH
G
PK
T
P
D
M-
K
---
G
S
A
--T
T
P
Q
V
A
DAI
C
K
II
fig|478007.5.peg.3682
Escherichia coli O157:H7 str. EC508 (1-359/361)
M
M
K
T
MR
IA
A
IPGDGIG
K
EV
L
P
EG
IR
VL
Q
AA
A
ER
W
---
GFA
L
S
FEQMEW
A
SCE
Y
YSH
HG
K
M
--
M
P
DD
W
H
E
QLS
R
F
DA
IY
FG
A
VG
---
W
PDTV
PD
HI
S
LW
G
S
L
----
L
K
F
R
R
EFD
Q
Y
V
NLRPVRL
FP
G
V
P
--
CPL
-
A
G
K
Q
P
GDI
D
FYV
VRENTEG
E
Y
-
SSLG
GR
VN
E
G
T
E
H
E
V
VI
QES
VF
T
R
R
G
V
-----------------------
D
RI
L
R
Y
AFE
L
A
QS
R
P
R
KT
L
TS
AT
K
S
N
G
L
AI
S
MPY
W
D
E
R
V
EA
M
A
E
N
Y
--------------------
PEI
RWDKQH
ID
ILCA
R
F
V
MQ
P
E
R
FDV
V
V
A
SNLFGDILSD
LG
P
A
C
TG
T
IGIAPSANLN
P
E
RT
F
P
S
LFEP
V
HGSAPDI
Y
GKNIANPIA
T
I
WA
G
AMML
D
F
L
G
NG
D
E
R
FQQ
A
H
NG
I
LA
AIE
E
V
I
AH
G
PK
T
P
D
M-
K
---
G
S
A
--T
T
P
Q
V
A
DAI
C
K
II
fig|478008.5.peg.3405
Escherichia coli O157:H7 str. EC869 (1-359/361)
M
M
K
T
MR
IA
A
IPGDGIG
K
EV
L
P
EG
IR
VL
Q
AA
A
ER
W
---
GFA
L
S
FEQMEW
A
SCE
Y
YSH
HG
K
M
--
M
P
DD
W
H
E
QLS
R
F
DA
IY
FG
A
VG
---
W
PDTV
PD
HI
S
LW
G
S
L
----
L
K
F
R
R
EFD
Q
Y
V
NLRPVRL
FP
G
V
P
--
CPL
-
A
G
K
Q
P
GDI
D
FYV
VRENTEG
E
Y
-
SSLG
GR
VN
E
G
T
E
H
E
V
VI
QES
VF
T
R
R
G
V
-----------------------
D
RI
L
R
Y
AFE
L
A
QS
R
P
R
KT
L
TS
AT
K
S
N
G
L
AI
S
MPY
W
D
E
R
V
EA
M
A
E
N
Y
--------------------
PEI
RWDKQH
ID
ILCA
R
F
V
MQ
P
E
R
FDV
V
V
A
SNLFGDILSD
LG
P
A
C
TG
T
IGIAPSANLN
P
E
RT
F
P
S
LFEP
V
HGSAPDI
Y
GKNIANPIA
T
I
WA
G
AMML
D
F
L
G
NG
D
E
R
FQQ
A
H
NG
I
LA
AIE
E
V
I
AH
G
PK
T
P
D
M-
K
---
G
S
A
--T
T
P
Q
V
A
DAI
C
K
II
fig|637388.3.peg.4786
Escherichia coli O157:H7 str. FRIK2000 (1-359/361)
M
M
K
T
MR
IA
A
IPGDGIG
K
EV
L
P
EG
IR
VL
Q
AA
A
ER
W
---
GFA
L
S
FEQMEW
A
SCE
Y
YSH
HG
K
M
--
M
P
DD
W
H
E
QLS
R
F
DA
IY
FG
A
VG
---
W
PDTV
PD
HI
S
LW
G
S
L
----
L
K
F
R
R
EFD
Q
Y
V
NLRPVRL
FP
G
V
P
--
CPL
-
A
G
K
Q
P
GDI
D
FYV
VRENTEG
E
Y
-
SSLG
GR
VN
E
G
T
E
H
E
V
VI
QES
VF
T
R
R
G
V
-----------------------
D
RI
L
R
Y
AFE
L
A
QS
R
P
R
KT
L
TS
AT
K
S
N
G
L
AI
S
MPY
W
D
E
R
V
EA
M
A
E
N
Y
--------------------
PEI
RWDKQH
ID
ILCA
R
F
V
MQ
P
E
R
FDV
V
V
A
SNLFGDILSD
LG
P
A
C
TG
T
IGIAPSANLN
P
E
RT
F
P
S
LFEP
V
HGSAPDI
Y
GKNIANPIA
T
I
WA
G
AMML
D
F
L
G
NG
D
E
R
FQQ
A
H
NG
I
LA
AIE
E
V
I
AH
G
PK
T
P
D
M-
K
---
G
S
A
--T
T
P
Q
V
A
DAI
C
K
II
fig|570506.3.peg.4018
Escherichia coli O157:H7 str. FRIK966 (1-359/361)
M
M
K
T
MR
IA
A
IPGDGIG
K
EV
L
P
EG
IR
VL
Q
AA
A
ER
W
---
GFA
L
S
FEQMEW
A
SCE
Y
YSH
HG
K
M
--
M
P
DD
W
H
E
QLS
R
F
DA
IY
FG
A
VG
---
W
PDTV
PD
HI
S
LW
G
S
L
----
L
K
F
R
R
EFD
Q
Y
V
NLRPVRL
FP
G
V
P
--
CPL
-
A
G
K
Q
P
GDI
D
FYV
VRENTEG
E
Y
-
SSLG
GR
VN
E
G
T
E
H
E
V
VI
QES
VF
T
R
R
G
V
-----------------------
D
RI
L
R
Y
AFE
L
A
QS
R
P
R
KT
L
TS
AT
K
S
N
G
L
AI
S
MPY
W
D
E
R
V
EA
M
A
E
N
Y
--------------------
PEI
RWDKQH
ID
ILCA
R
F
V
MQ
P
E
R
FDV
V
V
A
SNLFGDILSD
LG
P
A
C
TG
T
IGIAPSANLN
P
E
RT
F
P
S
LFEP
V
HGSAPDI
Y
GKNIANPIA
T
I
WA
G
AMML
D
F
L
G
NG
D
E
R
FQQ
A
H
NG
I
LA
AIE
E
V
I
AH
G
PK
T
P
D
M-
K
---
G
S
A
--T
T
P
Q
V
A
DAI
C
K
II
fig|386585.9.peg.2629
Escherichia coli O157:H7 str. Sakai (1-359/361)
M
M
K
T
MR
IA
A
IPGDGIG
K
EV
L
P
EG
IR
VL
Q
AA
A
ER
W
---
GFA
L
S
FEQMEW
A
SCE
Y
YSH
HG
K
M
--
M
P
DD
W
H
E
QLS
R
F
DA
IY
FG
A
VG
---
W
PDTV
PD
HI
S
LW
G
S
L
----
L
K
F
R
R
EFD
Q
Y
V
NLRPVRL
FP
G
V
P
--
CPL
-
A
G
K
Q
P
GDI
D
FYV
VRENTEG
E
Y
-
SSLG
GR
VN
E
G
T
E
H
E
V
VI
QES
VF
T
R
R
G
V
-----------------------
D
RI
L
R
Y
AFE
L
A
QS
R
P
R
KT
L
TS
AT
K
S
N
G
L
AI
S
MPY
W
D
E
R
V
EA
M
A
E
N
Y
--------------------
PEI
RWDKQH
ID
ILCA
R
F
V
MQ
P
E
R
FDV
V
V
A
SNLFGDILSD
LG
P
A
C
TG
T
IGIAPSANLN
P
E
RT
F
P
S
LFEP
V
HGSAPDI
Y
GKNIANPIA
T
I
WA
G
AMML
D
F
L
G
NG
D
E
R
FQQ
A
H
NG
I
LA
AIE
E
V
I
AH
G
PK
T
P
D
M-
K
---
G
S
A
--T
T
P
Q
V
A
DAI
C
K
II
fig|544404.4.peg.2427
Escherichia coli O157:H7 str. TW14359 (1-359/361)
M
M
K
T
MR
IA
A
IPGDGIG
K
EV
L
P
EG
IR
VL
Q
AA
A
ER
W
---
GFA
L
S
FEQMEW
A
SCE
Y
YSH
HG
K
M
--
M
P
DD
W
H
E
QLS
R
F
DA
IY
FG
A
VG
---
W
PDTV
PD
HI
S
LW
G
S
L
----
L
K
F
R
R
EFD
Q
Y
V
NLRPVRL
FP
G
V
P
--
CPL
-
A
G
K
Q
P
GDI
D
FYV
VRENTEG
E
Y
-
SSLG
GR
VN
E
G
T
E
H
E
V
VI
QES
VF
T
R
R
G
V
-----------------------
D
RI
L
R
Y
AFE
L
A
QS
R
P
R
KT
L
TS
AT
K
S
N
G
L
AI
S
MPY
W
D
E
R
V
EA
M
A
E
N
Y
--------------------
PEI
RWDKQH
ID
ILCA
R
F
V
MQ
P
E
R
FDV
V
V
A
SNLFGDILSD
LG
P
A
C
TG
T
IGIAPSANLN
P
E
RT
F
P
S
LFEP
V
HGSAPDI
Y
GKNIANPIA
T
I
WA
G
AMML
D
F
L
G
NG
D
E
R
FQQ
A
H
NG
I
LA
AIE
E
V
I
AH
G
PK
T
P
D
M-
K
---
G
S
A
--T
T
P
Q
V
A
DAI
C
K
II
fig|502346.5.peg.4881
Escherichia coli O157:H7 str. TW14588 (1-359/361)
M
M
K
T
MR
IA
A
IPGDGIG
K
EV
L
P
EG
IR
VL
Q
AA
A
ER
W
---
GFA
L
S
FEQMEW
A
SCE
Y
YSH
HG
K
M
--
M
P
DD
W
H
E
QLS
R
F
DA
IY
FG
A
VG
---
W
PDTV
PD
HI
S
LW
G
S
L
----
L
K
F
R
R
EFD
Q
Y
V
NLRPVRL
FP
G
V
P
--
CPL
-
A
G
K
Q
P
GDI
D
FYV
VRENTEG
E
Y
-
SSLG
GR
VN
E
G
T
E
H
E
V
VI
QES
VF
T
R
R
G
V
-----------------------
D
RI
L
R
Y
AFE
L
A
QS
R
P
R
KT
L
TS
AT
K
S
N
G
L
AI
S
MPY
W
D
E
R
V
EA
M
A
E
N
Y
--------------------
PEI
RWDKQH
ID
ILCA
R
F
V
MQ
P
E
R
FDV
V
V
A
SNLFGDILSD
LG
P
A
C
TG
T
IGIAPSANLN
P
E
RT
F
P
S
LFEP
V
HGSAPDI
Y
GKNIANPIA
T
I
WA
G
AMML
D
F
L
G
NG
D
E
R
FQQ
A
H
NG
I
LA
AIE
E
V
I
AH
G
PK
T
P
D
M-
K
---
G
S
A
--T
T
P
Q
V
A
DAI
C
K
II
fig|701177.3.peg.2252
Escherichia coli O55:H7 str. CB9615 (1-359/361)
M
M
K
T
MR
IA
A
IPGDGIG
K
EV
L
P
EG
IR
VL
Q
AA
A
ER
W
---
GFA
L
S
FEQMEW
A
SCE
Y
YSH
HG
K
M
--
M
P
DD
W
H
E
QLS
R
F
DA
IY
FG
A
VG
---
W
PDTV
PD
HI
S
LW
G
S
L
----
L
K
F
R
R
EFD
Q
Y
V
NLRPVRL
FP
G
V
P
--
CPL
-
A
G
K
Q
P
GDI
D
FYV
VRENTEG
E
Y
-
SSLG
GR
VN
E
G
T
E
H
E
V
VI
QES
VF
T
R
R
G
V
-----------------------
D
RI
L
R
Y
AFE
L
A
QS
R
P
R
KT
L
TS
AT
K
S
N
G
L
AI
S
MPY
W
D
E
R
V
EA
M
A
E
N
Y
--------------------
PEI
RWDKQH
ID
ILCA
R
F
V
MQ
P
E
R
FDV
V
V
A
SNLFGDILSD
LG
P
A
C
TG
T
IGIAPSANLN
P
E
RT
F
P
S
LFEP
V
HGSAPDI
Y
GKNIANPIA
T
I
WA
G
AMML
D
F
L
G
NG
D
E
R
FQQ
A
H
NG
I
LA
AIE
E
V
I
AH
G
PK
T
P
D
M-
K
---
G
S
A
--T
T
P
Q
V
A
DAI
C
K
II
fig|1040638.4.peg.3876
Escherichia coli O104:H4 str. LB226692 (1-359/361)
M
M
K
T
MR
IA
A
IPGDGIG
K
EV
L
P
EG
IR
VL
Q
AA
A
ER
W
---
GFA
L
S
FEQMEW
A
SCE
Y
YSH
HG
K
M
--
M
P
DD
W
H
E
QLS
R
F
DA
IY
FG
A
VG
---
W
PDTV
PD
HI
S
LW
G
S
L
----
L
K
F
R
R
EFD
Q
Y
V
NLRPVRL
FP
G
V
P
--
CPL
-
A
G
K
Q
P
GDI
D
FYV
VRENTEG
E
Y
-
SSLG
GR
VN
E
G
T
E
H
E
V
VI
QES
VF
T
R
R
G
V
-----------------------
D
RI
L
R
Y
AFE
L
A
QS
R
P
R
KT
L
TS
AT
K
S
N
G
L
AI
S
MPY
W
D
E
R
V
EA
M
A
E
N
Y
--------------------
PEI
RWDKQH
ID
ILCA
R
F
V
MQ
P
E
R
FDV
V
V
A
SNLFGDILSD
LG
P
A
C
TG
T
IGIAPSANLN
P
E
RT
F
P
S
LFEP
V
HGSAPDI
Y
GKNIANPIA
T
I
WA
G
AMML
D
F
L
G
NG
D
E
R
FQQ
A
H
NG
I
LA
AIE
E
V
I
AH
G
PK
T
P
D
M-
K
---
G
N
A
--T
T
P
Q
V
A
DAI
C
K
II
fig|670888.3.peg.313
Escherichia coli 1827-70 (1-359/361)
M
M
K
T
MR
IA
A
IPGDGIG
K
EV
L
P
EG
IR
VL
Q
AA
A
ER
W
---
GFA
L
S
FEQMEW
A
SCE
Y
YSH
HG
K
M
--
M
P
DD
W
H
E
QLS
R
F
DA
IY
FG
A
VG
---
W
PDTV
PD
HI
S
LW
G
S
L
----
L
K
F
R
R
EFD
Q
Y
V
NLRPVRL
FP
G
V
P
--
CPL
-
A
G
K
Q
P
GDI
D
FYV
VRENTEG
E
Y
-
SSLG
GR
VN
E
G
T
E
H
E
V
VI
QES
VF
T
R
R
G
V
-----------------------
D
RI
L
R
Y
AFE
L
A
QS
R
P
R
KT
L
TS
AT
K
S
N
G
L
AI
S
MPY
W
D
E
R
V
EA
M
A
E
N
Y
--------------------
PEI
RWDKQH
ID
ILCA
R
F
V
MQ
P
E
R
FDV
V
V
A
SNLFGDILSD
LG
P
A
C
TG
T
IGIAPSANLN
P
E
RT
F
P
S
LFEP
V
HGSAPDI
Y
GKNIANPIA
T
I
WA
G
AMML
D
F
L
G
NG
D
E
R
FQQ
A
H
NG
I
LA
AIE
E
V
I
AH
G
PK
T
P
D
M-
K
---
G
N
A
--T
T
P
Q
V
A
DAI
C
K
II
fig|344610.3.peg.2336
Escherichia coli 53638 (1-359/361)
M
M
K
T
MR
IA
A
IPGDGIG
K
EV
L
P
EG
IR
VL
Q
AA
A
ER
W
---
GFA
L
S
FEQMEW
A
SCE
Y
YSH
HG
K
M
--
M
P
DD
W
H
E
QLS
R
F
DA
IY
FG
A
VG
---
W
PDTV
PD
HI
S
LW
G
S
L
----
L
K
F
R
R
EFD
Q
Y
V
NLRPVRL
FP
G
V
P
--
CPL
-
A
G
K
Q
P
GDI
D
FYV
VRENTEG
E
Y
-
SSLG
GR
VN
E
G
T
E
H
E
V
VI
QES
VF
T
R
R
G
V
-----------------------
D
RI
L
R
Y
AFE
L
A
QS
R
P
R
KT
L
TS
AT
K
S
N
G
L
AI
S
MPY
W
D
E
R
V
EA
M
A
E
N
Y
--------------------
PEI
RWDKQH
ID
ILCA
R
F
V
MQ
P
E
R
FDV
V
V
A
SNLFGDILSD
LG
P
A
C
TG
T
IGIAPSANLN
P
E
RT
F
P
S
LFEP
V
HGSAPDI
Y
GKNIANPIA
T
I
WA
G
AMML
D
F
L
G
NG
D
E
R
FQQ
A
H
NG
I
LA
AIE
E
V
I
AH
G
PK
T
P
D
M-
K
---
G
N
A
--T
T
P
Q
V
A
DAI
C
K
II
fig|344610.7.peg.5465
Escherichia coli 53638 (1-359/361)
M
M
K
T
MR
IA
A
IPGDGIG
K
EV
L
P
EG
IR
VL
Q
AA
A
ER
W
---
GFA
L
S
FEQMEW
A
SCE
Y
YSH
HG
K
M
--
M
P
DD
W
H
E
QLS
R
F
DA
IY
FG
A
VG
---
W
PDTV
PD
HI
S
LW
G
S
L
----
L
K
F
R
R
EFD
Q
Y
V
NLRPVRL
FP
G
V
P
--
CPL
-
A
G
K
Q
P
GDI
D
FYV
VRENTEG
E
Y
-
SSLG
GR
VN
E
G
T
E
H
E
V
VI
QES
VF
T
R
R
G
V
-----------------------
D
RI
L
R
Y
AFE
L
A
QS
R
P
R
KT
L
TS
AT
K
S
N
G
L
AI
S
MPY
W
D
E
R
V
EA
M
A
E
N
Y
--------------------
PEI
RWDKQH
ID
ILCA
R
F
V
MQ
P
E
R
FDV
V
V
A
SNLFGDILSD
LG
P
A
C
TG
T
IGIAPSANLN
P
E
RT
F
P
S
LFEP
V
HGSAPDI
Y
GKNIANPIA
T
I
WA
G
AMML
D
F
L
G
NG
D
E
R
FQQ
A
H
NG
I
LA
AIE
E
V
I
AH
G
PK
T
P
D
M-
K
---
G
N
A
--T
T
P
Q
V
A
DAI
C
K
II
fig|585055.6.peg.2003
Escherichia coli 55989 (1-359/361)
M
M
K
T
MR
IA
A
IPGDGIG
K
EV
L
P
EG
IR
VL
Q
AA
A
ER
W
---
GFA
L
S
FEQMEW
A
SCE
Y
YSH
HG
K
M
--
M
P
DD
W
H
E
QLS
R
F
DA
IY
FG
A
VG
---
W
PDTV
PD
HI
S
LW
G
S
L
----
L
K
F
R
R
EFD
Q
Y
V
NLRPVRL
FP
G
V
P
--
CPL
-
A
G
K
Q
P
GDI
D
FYV
VRENTEG
E
Y
-
SSLG
GR
VN
E
G
T
E
H
E
V
VI
QES
VF
T
R
R
G
V
-----------------------
D
RI
L
R
Y
AFE
L
A
QS
R
P
R
KT
L
TS
AT
K
S
N
G
L
AI
S
MPY
W
D
E
R
V
EA
M
A
E
N
Y
--------------------
PEI
RWDKQH
ID
ILCA
R
F
V
MQ
P
E
R
FDV
V
V
A
SNLFGDILSD
LG
P
A
C
TG
T
IGIAPSANLN
P
E
RT
F
P
S
LFEP
V
HGSAPDI
Y
GKNIANPIA
T
I
WA
G
AMML
D
F
L
G
NG
D
E
R
FQQ
A
H
NG
I
LA
AIE
E
V
I
AH
G
PK
T
P
D
M-
K
---
G
N
A
--T
T
P
Q
V
A
DAI
C
K
II
fig|585055.8.peg.2006
Escherichia coli 55989 (1-359/361)
M
M
K
T
MR
IA
A
IPGDGIG
K
EV
L
P
EG
IR
VL
Q
AA
A
ER
W
---
GFA
L
S
FEQMEW
A
SCE
Y
YSH
HG
K
M
--
M
P
DD
W
H
E
QLS
R
F
DA
IY
FG
A
VG
---
W
PDTV
PD
HI
S
LW
G
S
L
----
L
K
F
R
R
EFD
Q
Y
V
NLRPVRL
FP
G
V
P
--
CPL
-
A
G
K
Q
P
GDI
D
FYV
VRENTEG
E
Y
-
SSLG
GR
VN
E
G
T
E
H
E
V
VI
QES
VF
T
R
R
G
V
-----------------------
D
RI
L
R
Y
AFE
L
A
QS
R
P
R
KT
L
TS
AT
K
S
N
G
L
AI
S
MPY
W
D
E
R
V
EA
M
A
E
N
Y
--------------------
PEI
RWDKQH
ID
ILCA
R
F
V
MQ
P
E
R
FDV
V
V
A
SNLFGDILSD
LG
P
A
C
TG
T
IGIAPSANLN
P
E
RT
F
P
S
LFEP
V
HGSAPDI
Y
GKNIANPIA
T
I
WA
G
AMML
D
F
L
G
NG
D
E
R
FQQ
A
H
NG
I
LA
AIE
E
V
I
AH
G
PK
T
P
D
M-
K
---
G
N
A
--T
T
P
Q
V
A
DAI
C
K
II
fig|481805.3.peg.1976
Escherichia coli ATCC 8739 (1-359/361)
M
M
K
T
MR
IA
A
IPGDGIG
K
EV
L
P
EG
IR
VL
Q
AA
A
ER
W
---
GFA
L
S
FEQMEW
A
SCE
Y
YSH
HG
K
M
--
M
P
DD
W
H
E
QLS
R
F
DA
IY
FG
A
VG
---
W
PDTV
PD
HI
S
LW
G
S
L
----
L
K
F
R
R
EFD
Q
Y
V
NLRPVRL
FP
G
V
P
--
CPL
-
A
G
K
Q
P
GDI
D
FYV
VRENTEG
E
Y
-
SSLG
GR
VN
E
G
T
E
H
E
V
VI
QES
VF
T
R
R
G
V
-----------------------
D
RI
L
R
Y
AFE
L
A
QS
R
P
R
KT
L
TS
AT
K
S
N
G
L
AI
S
MPY
W
D
E
R
V
EA
M
A
E
N
Y
--------------------
PEI
RWDKQH
ID
ILCA
R
F
V
MQ
P
E
R
FDV
V
V
A
SNLFGDILSD
LG
P
A
C
TG
T
IGIAPSANLN
P
E
RT
F
P
S
LFEP
V
HGSAPDI
Y
GKNIANPIA
T
I
WA
G
AMML
D
F
L
G
NG
D
E
R
FQQ
A
H
NG
I
LA
AIE
E
V
I
AH
G
PK
T
P
D
M-
K
---
G
N
A
--T
T
P
Q
V
A
DAI
C
K
II
fig|481805.6.peg.1970
Escherichia coli ATCC 8739 (1-359/361)
M
M
K
T
MR
IA
A
IPGDGIG
K
EV
L
P
EG
IR
VL
Q
AA
A
ER
W
---
GFA
L
S
FEQMEW
A
SCE
Y
YSH
HG
K
M
--
M
P
DD
W
H
E
QLS
R
F
DA
IY
FG
A
VG
---
W
PDTV
PD
HI
S
LW
G
S
L
----
L
K
F
R
R
EFD
Q
Y
V
NLRPVRL
FP
G
V
P
--
CPL
-
A
G
K
Q
P
GDI
D
FYV
VRENTEG
E
Y
-
SSLG
GR
VN
E
G
T
E
H
E
V
VI
QES
VF
T
R
R
G
V
-----------------------
D
RI
L
R
Y
AFE
L
A
QS
R
P
R
KT
L
TS
AT
K
S
N
G
L
AI
S
MPY
W
D
E
R
V
EA
M
A
E
N
Y
--------------------
PEI
RWDKQH
ID
ILCA
R
F
V
MQ
P
E
R
FDV
V
V
A
SNLFGDILSD
LG
P
A
C
TG
T
IGIAPSANLN
P
E
RT
F
P
S
LFEP
V
HGSAPDI
Y
GKNIANPIA
T
I
WA
G
AMML
D
F
L
G
NG
D
E
R
FQQ
A
H
NG
I
LA
AIE
E
V
I
AH
G
PK
T
P
D
M-
K
---
G
N
A
--T
T
P
Q
V
A
DAI
C
K
II
fig|550672.3.peg.1530
Escherichia coli B088 (1-359/361)
M
M
K
T
MR
IA
A
IPGDGIG
K
EV
L
P
EG
IR
VL
Q
AA
A
ER
W
---
GFA
L
S
FEQMEW
A
SCE
Y
YSH
HG
K
M
--
M
P
DD
W
H
E
QLS
R
F
DA
IY
FG
A
VG
---
W
PDTV
PD
HI
S
LW
G
S
L
----
L
K
F
R
R
EFD
Q
Y
V
NLRPVRL
FP
G
V
P
--
CPL
-
A
G
K
Q
P
GDI
D
FYV
VRENTEG
E
Y
-
SSLG
GR
VN
E
G
T
E
H
E
V
VI
QES
VF
T
R
R
G
V
-----------------------
D
RI
L
R
Y
AFE
L
A
QS
R
P
R
KT
L
TS
AT
K
S
N
G
L
AI
S
MPY
W
D
E
R
V
EA
M
A
E
N
Y
--------------------
PEI
RWDKQH
ID
ILCA
R
F
V
MQ
P
E
R
FDV
V
V
A
SNLFGDILSD
LG
P
A
C
TG
T
IGIAPSANLN
P
E
RT
F
P
S
LFEP
V
HGSAPDI
Y
GKNIANPIA
T
I
WA
G
AMML
D
F
L
G
NG
D
E
R
FQQ
A
H
NG
I
LA
AIE
E
V
I
AH
G
PK
T
P
D
M-
K
---
G
N
A
--T
T
P
Q
V
A
DAI
C
K
II
fig|550677.3.peg.1286
Escherichia coli B354 (1-359/361)
M
M
K
T
MR
IA
A
IPGDGIG
K
EV
L
P
EG
IR
VL
Q
AA
A
ER
W
---
GFA
L
S
FEQMEW
A
SCE
Y
YSH
HG
K
M
--
M
P
DD
W
H
E
QLS
R
F
DA
IY
FG
A
VG
---
W
PDTV
PD
HI
S
LW
G
S
L
----
L
K
F
R
R
EFD
Q
Y
V
NLRPVRL
FP
G
V
P
--
CPL
-
A
G
K
Q
P
GDI
D
FYV
VRENTEG
E
Y
-
SSLG
GR
VN
E
G
T
E
H
E
V
VI
QES
VF
T
R
R
G
V
-----------------------
D
RI
L
R
Y
AFE
L
A
QS
R
P
R
KT
L
TS
AT
K
S
N
G
L
AI
S
MPY
W
D
E
R
V
EA
M
A
E
N
Y
--------------------
PEI
RWDKQH
ID
ILCA
R
F
V
MQ
P
E
R
FDV
V
V
A
SNLFGDILSD
LG
P
A
C
TG
T
IGIAPSANLN
P
E
RT
F
P
S
LFEP
V
HGSAPDI
Y
GKNIANPIA
T
I
WA
G
AMML
D
F
L
G
NG
D
E
R
FQQ
A
H
NG
I
LA
AIE
E
V
I
AH
G
PK
T
P
D
M-
K
---
G
N
A
--T
T
P
Q
V
A
DAI
C
K
II
fig|340184.3.peg.3950
Escherichia coli B7A (1-359/361)
M
M
K
T
MR
IA
A
IPGDGIG
K
EV
L
P
EG
IR
VL
Q
AA
A
ER
W
---
GFA
L
S
FEQMEW
A
SCE
Y
YSH
HG
K
M
--
M
P
DD
W
H
E
QLS
R
F
DA
IY
FG
A
VG
---
W
PDTV
PD
HI
S
LW
G
S
L
----
L
K
F
R
R
EFD
Q
Y
V
NLRPVRL
FP
G
V
P
--
CPL
-
A
G
K
Q
P
GDI
D
FYV
VRENTEG
E
Y
-
SSLG
GR
VN
E
G
T
E
H
E
V
VI
QES
VF
T
R
R
G
V
-----------------------
D
RI
L
R
Y
AFE
L
A
QS
R
P
R
KT
L
TS
AT
K
S
N
G
L
AI
S
MPY
W
D
E
R
V
EA
M
A
E
N
Y
--------------------
PEI
RWDKQH
ID
ILCA
R
F
V
MQ
P
E
R
FDV
V
V
A
SNLFGDILSD
LG
P
A
C
TG
T
IGIAPSANLN
P
E
RT
F
P
S
LFEP
V
HGSAPDI
Y
GKNIANPIA
T
I
WA
G
AMML
D
F
L
G
NG
D
E
R
FQQ
A
H
NG
I
LA
AIE
E
V
I
AH
G
PK
T
P
D
M-
K
---
G
N
A
--T
T
P
Q
V
A
DAI
C
K
II
fig|340184.6.peg.4130
Escherichia coli B7A (1-359/361)
M
M
K
T
MR
IA
A
IPGDGIG
K
EV
L
P
EG
IR
VL
Q
AA
A
ER
W
---
GFA
L
S
FEQMEW
A
SCE
Y
YSH
HG
K
M
--
M
P
DD
W
H
E
QLS
R
F
DA
IY
FG
A
VG
---
W
PDTV
PD
HI
S
LW
G
S
L
----
L
K
F
R
R
EFD
Q
Y
V
NLRPVRL
FP
G
V
P
--
CPL
-
A
G
K
Q
P
GDI
D
FYV
VRENTEG
E
Y
-
SSLG
GR
VN
E
G
T
E
H
E
V
VI
QES
VF
T
R
R
G
V
-----------------------
D
RI
L
R
Y
AFE
L
A
QS
R
P
R
KT
L
TS
AT
K
S
N
G
L
AI
S
MPY
W
D
E
R
V
EA
M
A
E
N
Y
--------------------
PEI
RWDKQH
ID
ILCA
R
F
V
MQ
P
E
R
FDV
V
V
A
SNLFGDILSD
LG
P
A
C
TG
T
IGIAPSANLN
P
E
RT
F
P
S
LFEP
V
HGSAPDI
Y
GKNIANPIA
T
I
WA
G
AMML
D
F
L
G
NG
D
E
R
FQQ
A
H
NG
I
LA
AIE
E
V
I
AH
G
PK
T
P
D
M-
K
---
G
N
A
--T
T
P
Q
V
A
DAI
C
K
II
fig|595496.3.peg.1766
Escherichia coli BW2952 (1-359/361)
M
M
K
T
MR
IA
A
IPGDGIG
K
EV
L
P
EG
IR
VL
Q
AA
A
ER
W
---
GFA
L
S
FEQMEW
A
SCE
Y
YSH
HG
K
M
--
M
P
DD
W
H
E
QLS
R
F
DA
IY
FG
A
VG
---
W
PDTV
PD
HI
S
LW
G
S
L
----
L
K
F
R
R
EFD
Q
Y
V
NLRPVRL
FP
G
V
P
--
CPL
-
A
G
K
Q
P
GDI
D
FYV
VRENTEG
E
Y
-
SSLG
GR
VN
E
G
T
E
H
E
V
VI
QES
VF
T
R
R
G
V
-----------------------
D
RI
L
R
Y
AFE
L
A
QS
R
P
R
KT
L
TS
AT
K
S
N
G
L
AI
S
MPY
W
D
E
R
V
EA
M
A
E
N
Y
--------------------
PEI
RWDKQH
ID
ILCA
R
F
V
MQ
P
E
R
FDV
V
V
A
SNLFGDILSD
LG
P
A
C
TG
T
IGIAPSANLN
P
E
RT
F
P
S
LFEP
V
HGSAPDI
Y
GKNIANPIA
T
I
WA
G
AMML
D
F
L
G
NG
D
E
R
FQQ
A
H
NG
I
LA
AIE
E
V
I
AH
G
PK
T
P
D
M-
K
---
G
N
A
--T
T
P
Q
V
A
DAI
C
K
II
fig|536056.3.peg.1948
Escherichia coli DH1 (1-359/361)
M
M
K
T
MR
IA
A
IPGDGIG
K
EV
L
P
EG
IR
VL
Q
AA
A
ER
W
---
GFA
L
S
FEQMEW
A
SCE
Y
YSH
HG
K
M
--
M
P
DD
W
H
E
QLS
R
F
DA
IY
FG
A
VG
---
W
PDTV
PD
HI
S
LW
G
S
L
----
L
K
F
R
R
EFD
Q
Y
V
NLRPVRL
FP
G
V
P
--
CPL
-
A
G
K
Q
P
GDI
D
FYV
VRENTEG
E
Y
-
SSLG
GR
VN
E
G
T
E
H
E
V
VI
QES
VF
T
R
R
G
V
-----------------------
D
RI
L
R
Y
AFE
L
A
QS
R
P
R
KT
L
TS
AT
K
S
N
G
L
AI
S
MPY
W
D
E
R
V
EA
M
A
E
N
Y
--------------------
PEI
RWDKQH
ID
ILCA
R
F
V
MQ
P
E
R
FDV
V
V
A
SNLFGDILSD
LG
P
A
C
TG
T
IGIAPSANLN
P
E
RT
F
P
S
LFEP
V
HGSAPDI
Y
GKNIANPIA
T
I
WA
G
AMML
D
F
L
G
NG
D
E
R
FQQ
A
H
NG
I
LA
AIE
E
V
I
AH
G
PK
T
P
D
M-
K
---
G
N
A
--T
T
P
Q
V
A
DAI
C
K
II
fig|340186.3.peg.4509
Escherichia coli E110019 (1-359/361)
M
M
K
T
MR
IA
A
IPGDGIG
K
EV
L
P
EG
IR
VL
Q
AA
A
ER
W
---
GFA
L
S
FEQMEW
A
SCE
Y
YSH
HG
K
M
--
M
P
DD
W
H
E
QLS
R
F
DA
IY
FG
A
VG
---
W
PDTV
PD
HI
S
LW
G
S
L
----
L
K
F
R
R
EFD
Q
Y
V
NLRPVRL
FP
G
V
P
--
CPL
-
A
G
K
Q
P
GDI
D
FYV
VRENTEG
E
Y
-
SSLG
GR
VN
E
G
T
E
H
E
V
VI
QES
VF
T
R
R
G
V
-----------------------
D
RI
L
R
Y
AFE
L
A
QS
R
P
R
KT
L
TS
AT
K
S
N
G
L
AI
S
MPY
W
D
E
R
V
EA
M
A
E
N
Y
--------------------
PEI
RWDKQH
ID
ILCA
R
F
V
MQ
P
E
R
FDV
V
V
A
SNLFGDILSD
LG
P
A
C
TG
T
IGIAPSANLN
P
E
RT
F
P
S
LFEP
V
HGSAPDI
Y
GKNIANPIA
T
I
WA
G
AMML
D
F
L
G
NG
D
E
R
FQQ
A
H
NG
I
LA
AIE
E
V
I
AH
G
PK
T
P
D
M-
K
---
G
N
A
--T
T
P
Q
V
A
DAI
C
K
II
fig|340186.5.peg.4744
Escherichia coli E110019 (1-359/361)
M
M
K
T
MR
IA
A
IPGDGIG
K
EV
L
P
EG
IR
VL
Q
AA
A
ER
W
---
GFA
L
S
FEQMEW
A
SCE
Y
YSH
HG
K
M
--
M
P
DD
W
H
E
QLS
R
F
DA
IY
FG
A
VG
---
W
PDTV
PD
HI
S
LW
G
S
L
----
L
K
F
R
R
EFD
Q
Y
V
NLRPVRL
FP
G
V
P
--
CPL
-
A
G
K
Q
P
GDI
D
FYV
VRENTEG
E
Y
-
SSLG
GR
VN
E
G
T
E
H
E
V
VI
QES
VF
T
R
R
G
V
-----------------------
D
RI
L
R
Y
AFE
L
A
QS
R
P
R
KT
L
TS
AT
K
S
N
G
L
AI
S
MPY
W
D
E
R
V
EA
M
A
E
N
Y
--------------------
PEI
RWDKQH
ID
ILCA
R
F
V
MQ
P
E
R
FDV
V
V
A
SNLFGDILSD
LG
P
A
C
TG
T
IGIAPSANLN
P
E
RT
F
P
S
LFEP
V
HGSAPDI
Y
GKNIANPIA
T
I
WA
G
AMML
D
F
L
G
NG
D
E
R
FQQ
A
H
NG
I
LA
AIE
E
V
I
AH
G
PK
T
P
D
M-
K
---
G
N
A
--T
T
P
Q
V
A
DAI
C
K
II
fig|331111.12.peg.2304
Escherichia coli E24377A (1-359/361)
M
M
K
T
MR
IA
A
IPGDGIG
K
EV
L
P
EG
IR
VL
Q
AA
A
ER
W
---
GFA
L
S
FEQMEW
A
SCE
Y
YSH
HG
K
M
--
M
P
DD
W
H
E
QLS
R
F
DA
IY
FG
A
VG
---
W
PDTV
PD
HI
S
LW
G
S
L
----
L
K
F
R
R
EFD
Q
Y
V
NLRPVRL
FP
G
V
P
--
CPL
-
A
G
K
Q
P
GDI
D
FYV
VRENTEG
E
Y
-
SSLG
GR
VN
E
G
T
E
H
E
V
VI
QES
VF
T
R
R
G
V
-----------------------
D
RI
L
R
Y
AFE
L
A
QS
R
P
R
KT
L
TS
AT
K
S
N
G
L
AI
S
MPY
W
D
E
R
V
EA
M
A
E
N
Y
--------------------
PEI
RWDKQH
ID
ILCA
R
F
V
MQ
P
E
R
FDV
V
V
A
SNLFGDILSD
LG
P
A
C
TG
T
IGIAPSANLN
P
E
RT
F
P
S
LFEP
V
HGSAPDI
Y
GKNIANPIA
T
I
WA
G
AMML
D
F
L
G
NG
D
E
R
FQQ
A
H
NG
I
LA
AIE
E
V
I
AH
G
PK
T
P
D
M-
K
---
G
N
A
--T
T
P
Q
V
A
DAI
C
K
II
fig|331111.3.peg.4447
Escherichia coli E24377A (1-359/361)
M
M
K
T
MR
IA
A
IPGDGIG
K
EV
L
P
EG
IR
VL
Q
AA
A
ER
W
---
GFA
L
S
FEQMEW
A
SCE
Y
YSH
HG
K
M
--
M
P
DD
W
H
E
QLS
R
F
DA
IY
FG
A
VG
---
W
PDTV
PD
HI
S
LW
G
S
L
----
L
K
F
R
R
EFD
Q
Y
V
NLRPVRL
FP
G
V
P
--
CPL
-
A
G
K
Q
P
GDI
D
FYV
VRENTEG
E
Y
-
SSLG
GR
VN
E
G
T
E
H
E
V
VI
QES
VF
T
R
R
G
V
-----------------------
D
RI
L
R
Y
AFE
L
A
QS
R
P
R
KT
L
TS
AT
K
S
N
G
L
AI
S
MPY
W
D
E
R
V
EA
M
A
E
N
Y
--------------------
PEI
RWDKQH
ID
ILCA
R
F
V
MQ
P
E
R
FDV
V
V
A
SNLFGDILSD
LG
P
A
C
TG
T
IGIAPSANLN
P
E
RT
F
P
S
LFEP
V
HGSAPDI
Y
GKNIANPIA
T
I
WA
G
AMML
D
F
L
G
NG
D
E
R
FQQ
A
H
NG
I
LA
AIE
E
V
I
AH
G
PK
T
P
D
M-
K
---
G
N
A
--T
T
P
Q
V
A
DAI
C
K
II
fig|562.375.peg.1915
Escherichia coli EC4100B (1-359/361)
M
M
K
T
MR
IA
A
IPGDGIG
K
EV
L
P
EG
IR
VL
Q
AA
A
ER
W
---
GFA
L
S
FEQMEW
A
SCE
Y
YSH
HG
K
M
--
M
P
DD
W
H
E
QLS
R
F
DA
IY
FG
A
VG
---
W
PDTV
PD
HI
S
LW
G
S
L
----
L
K
F
R
R
EFD
Q
Y
V
NLRPVRL
FP
G
V
P
--
CPL
-
A
G
K
Q
P
GDI
D
FYV
VRENTEG
E
Y
-
SSLG
GR
VN
E
G
T
E
H
E
V
VI
QES
VF
T
R
R
G
V
-----------------------
D
RI
L
R
Y
AFE
L
A
QS
R
P
R
KT
L
TS
AT
K
S
N
G
L
AI
S
MPY
W
D
E
R
V
EA
M
A
E
N
Y
--------------------
PEI
RWDKQH
ID
ILCA
R
F
V
MQ
P
E
R
FDV
V
V
A
SNLFGDILSD
LG
P
A
C
TG
T
IGIAPSANLN
P
E
RT
F
P
S
LFEP
V
HGSAPDI
Y
GKNIANPIA
T
I
WA
G
AMML
D
F
L
G
NG
D
E
R
FQQ
A
H
NG
I
LA
AIE
E
V
I
AH
G
PK
T
P
D
M-
K
---
G
N
A
--T
T
P
Q
V
A
DAI
C
K
II
fig|316401.4.peg.2098
Escherichia coli ETEC H10407 (1-359/361)
M
M
K
T
MR
IA
A
IPGDGIG
K
EV
L
P
EG
IR
VL
Q
AA
A
ER
W
---
GFA
L
S
FEQMEW
A
SCE
Y
YSH
HG
K
M
--
M
P
DD
W
H
E
QLS
R
F
DA
IY
FG
A
VG
---
W
PDTV
PD
HI
S
LW
G
S
L
----
L
K
F
R
R
EFD
Q
Y
V
NLRPVRL
FP
G
V
P
--
CPL
-
A
G
K
Q
P
GDI
D
FYV
VRENTEG
E
Y
-
SSLG
GR
VN
E
G
T
E
H
E
V
VI
QES
VF
T
R
R
G
V
-----------------------
D
RI
L
R
Y
AFE
L
A
QS
R
P
R
KT
L
TS
AT
K
S
N
G
L
AI
S
MPY
W
D
E
R
V
EA
M
A
E
N
Y
--------------------
PEI
RWDKQH
ID
ILCA
R
F
V
MQ
P
E
R
FDV
V
V
A
SNLFGDILSD
LG
P
A
C
TG
T
IGIAPSANLN
P
E
RT
F
P
S
LFEP
V
HGSAPDI
Y
GKNIANPIA
T
I
WA
G
AMML
D
F
L
G
NG
D
E
R
FQQ
A
H
NG
I
LA
AIE
E
V
I
AH
G
PK
T
P
D
M-
K
---
G
N
A
--T
T
P
Q
V
A
DAI
C
K
II
fig|656408.3.peg.1966
Escherichia coli H591 (1-359/361)
M
M
K
T
MR
IA
A
IPGDGIG
K
EV
L
P
EG
IR
VL
Q
AA
A
ER
W
---
GFA
L
S
FEQMEW
A
SCE
Y
YSH
HG
K
M
--
M
P
DD
W
H
E
QLS
R
F
DA
IY
FG
A
VG
---
W
PDTV
PD
HI
S
LW
G
S
L
----
L
K
F
R
R
EFD
Q
Y
V
NLRPVRL
FP
G
V
P
--
CPL
-
A
G
K
Q
P
GDI
D
FYV
VRENTEG
E
Y
-
SSLG
GR
VN
E
G
T
E
H
E
V
VI
QES
VF
T
R
R
G
V
-----------------------
D
RI
L
R
Y
AFE
L
A
QS
R
P
R
KT
L
TS
AT
K
S
N
G
L
AI
S
MPY
W
D
E
R
V
EA
M
A
E
N
Y
--------------------
PEI
RWDKQH
ID
ILCA
R
F
V
MQ
P
E
R
FDV
V
V
A
SNLFGDILSD
LG
P
A
C
TG
T
IGIAPSANLN
P
E
RT
F
P
S
LFEP
V
HGSAPDI
Y
GKNIANPIA
T
I
WA
G
AMML
D
F
L
G
NG
D
E
R
FQQ
A
H
NG
I
LA
AIE
E
V
I
AH
G
PK
T
P
D
M-
K
---
G
N
A
--T
T
P
Q
V
A
DAI
C
K
II
fig|656414.3.peg.2133
Escherichia coli H736 (1-359/361)
M
M
K
T
MR
IA
A
IPGDGIG
K
EV
L
P
EG
IR
VL
Q
AA
A
ER
W
---
GFA
L
S
FEQMEW
A
SCE
Y
YSH
HG
K
M
--
M
P
DD
W
H
E
QLS
R
F
DA
IY
FG
A
VG
---
W
PDTV
PD
HI
S
LW
G
S
L
----
L
K
F
R
R
EFD
Q
Y
V
NLRPVRL
FP
G
V
P
--
CPL
-
A
G
K
Q
P
GDI
D
FYV
VRENTEG
E
Y
-
SSLG
GR
VN
E
G
T
E
H
E
V
VI
QES
VF
T
R
R
G
V
-----------------------
D
RI
L
R
Y
AFE
L
A
QS
R
P
R
KT
L
TS
AT
K
S
N
G
L
AI
S
MPY
W
D
E
R
V
EA
M
A
E
N
Y
--------------------
PEI
RWDKQH
ID
ILCA
R
F
V
MQ
P
E
R
FDV
V
V
A
SNLFGDILSD
LG
P
A
C
TG
T
IGIAPSANLN
P
E
RT
F
P
S
LFEP
V
HGSAPDI
Y
GKNIANPIA
T
I
WA
G
AMML
D
F
L
G
NG
D
E
R
FQQ
A
H
NG
I
LA
AIE
E
V
I
AH
G
PK
T
P
D
M-
K
---
G
N
A
--T
T
P
Q
V
A
DAI
C
K
II
fig|331112.3.peg.1778
Escherichia coli HS (1-359/361)
M
M
K
T
MR
IA
A
IPGDGIG
K
EV
L
P
EG
IR
VL
Q
AA
A
ER
W
---
GFA
L
S
FEQMEW
A
SCE
Y
YSH
HG
K
M
--
M
P
DD
W
H
E
QLS
R
F
DA
IY
FG
A
VG
---
W
PDTV
PD
HI
S
LW
G
S
L
----
L
K
F
R
R
EFD
Q
Y
V
NLRPVRL
FP
G
V
P
--
CPL
-
A
G
K
Q
P
GDI
D
FYV
VRENTEG
E
Y
-
SSLG
GR
VN
E
G
T
E
H
E
V
VI
QES
VF
T
R
R
G
V
-----------------------
D
RI
L
R
Y
AFE
L
A
QS
R
P
R
KT
L
TS
AT
K
S
N
G
L
AI
S
MPY
W
D
E
R
V
EA
M
A
E
N
Y
--------------------
PEI
RWDKQH
ID
ILCA
R
F
V
MQ
P
E
R
FDV
V
V
A
SNLFGDILSD
LG
P
A
C
TG
T
IGIAPSANLN
P
E
RT
F
P
S
LFEP
V
HGSAPDI
Y
GKNIANPIA
T
I
WA
G
AMML
D
F
L
G
NG
D
E
R
FQQ
A
H
NG
I
LA
AIE
E
V
I
AH
G
PK
T
P
D
M-
K
---
G
N
A
--T
T
P
Q
V
A
DAI
C
K
II
fig|331112.6.peg.1848
Escherichia coli HS (1-359/361)
M
M
K
T
MR
IA
A
IPGDGIG
K
EV
L
P
EG
IR
VL
Q
AA
A
ER
W
---
GFA
L
S
FEQMEW
A
SCE
Y
YSH
HG
K
M
--
M
P
DD
W
H
E
QLS
R
F
DA
IY
FG
A
VG
---
W
PDTV
PD
HI
S
LW
G
S
L
----
L
K
F
R
R
EFD
Q
Y
V
NLRPVRL
FP
G
V
P
--
CPL
-
A
G
K
Q
P
GDI
D
FYV
VRENTEG
E
Y
-
SSLG
GR
VN
E
G
T
E
H
E
V
VI
QES
VF
T
R
R
G
V
-----------------------
D
RI
L
R
Y
AFE
L
A
QS
R
P
R
KT
L
TS
AT
K
S
N
G
L
AI
S
MPY
W
D
E
R
V
EA
M
A
E
N
Y
--------------------
PEI
RWDKQH
ID
ILCA
R
F
V
MQ
P
E
R
FDV
V
V
A
SNLFGDILSD
LG
P
A
C
TG
T
IGIAPSANLN
P
E
RT
F
P
S
LFEP
V
HGSAPDI
Y
GKNIANPIA
T
I
WA
G
AMML
D
F
L
G
NG
D
E
R
FQQ
A
H
NG
I
LA
AIE
E
V
I
AH
G
PK
T
P
D
M-
K
---
G
N
A
--T
T
P
Q
V
A
DAI
C
K
II
fig|83333.1.peg.1783
Escherichia coli K12 (1-359/361)
M
M
K
T
MR
IA
A
IPGDGIG
K
EV
L
P
EG
IR
VL
Q
AA
A
ER
W
---
GFA
L
S
FEQMEW
A
SCE
Y
YSH
HG
K
M
--
M
P
DD
W
H
E
QLS
R
F
DA
IY
FG
A
VG
---
W
PDTV
PD
HI
S
LW
G
S
L
----
L
K
F
R
R
EFD
Q
Y
V
NLRPVRL
FP
G
V
P
--
CPL
-
A
G
K
Q
P
GDI
D
FYV
VRENTEG
E
Y
-
SSLG
GR
VN
E
G
T
E
H
E
V
VI
QES
VF
T
R
R
G
V
-----------------------
D
RI
L
R
Y
AFE
L
A
QS
R
P
R
KT
L
TS
AT
K
S
N
G
L
AI
S
MPY
W
D
E
R
V
EA
M
A
E
N
Y
--------------------
PEI
RWDKQH
ID
ILCA
R
F
V
MQ
P
E
R
FDV
V
V
A
SNLFGDILSD
LG
P
A
C
TG
T
IGIAPSANLN
P
E
RT
F
P
S
LFEP
V
HGSAPDI
Y
GKNIANPIA
T
I
WA
G
AMML
D
F
L
G
NG
D
E
R
FQQ
A
H
NG
I
LA
AIE
E
V
I
AH
G
PK
T
P
D
M-
K
---
G
N
A
--T
T
P
Q
V
A
DAI
C
K
II
fig|595495.4.peg.3858
Escherichia coli KO11 (1-359/361)
M
M
K
T
MR
IA
A
IPGDGIG
K
EV
L
P
EG
IR
VL
Q
AA
A
ER
W
---
GFA
L
S
FEQMEW
A
SCE
Y
YSH
HG
K
M
--
M
P
DD
W
H
E
QLS
R
F
DA
IY
FG
A
VG
---
W
PDTV
PD
HI
S
LW
G
S
L
----
L
K
F
R
R
EFD
Q
Y
V
NLRPVRL
FP
G
V
P
--
CPL
-
A
G
K
Q
P
GDI
D
FYV
VRENTEG
E
Y
-
SSLG
GR
VN
E
G
T
E
H
E
V
VI
QES
VF
T
R
R
G
V
-----------------------
D
RI
L
R
Y
AFE
L
A
QS
R
P
R
KT
L
TS
AT
K
S
N
G
L
AI
S
MPY
W
D
E
R
V
EA
M
A
E
N
Y
--------------------
PEI
RWDKQH
ID
ILCA
R
F
V
MQ
P
E
R
FDV
V
V
A
SNLFGDILSD
LG
P
A
C
TG
T
IGIAPSANLN
P
E
RT
F
P
S
LFEP
V
HGSAPDI
Y
GKNIANPIA
T
I
WA
G
AMML
D
F
L
G
NG
D
E
R
FQQ
A
H
NG
I
LA
AIE
E
V
I
AH
G
PK
T
P
D
M-
K
---
G
N
A
--T
T
P
Q
V
A
DAI
C
K
II
fig|679207.4.peg.1323
Escherichia coli MS 107-1 (1-359/361)
M
M
K
T
MR
IA
A
IPGDGIG
K
EV
L
P
EG
IR
VL
Q
AA
A
ER
W
---
GFA
L
S
FEQMEW
A
SCE
Y
YSH
HG
K
M
--
M
P
DD
W
H
E
QLS
R
F
DA
IY
FG
A
VG
---
W
PDTV
PD
HI
S
LW
G
S
L
----
L
K
F
R
R
EFD
Q
Y
V
NLRPVRL
FP
G
V
P
--
CPL
-
A
G
K
Q
P
GDI
D
FYV
VRENTEG
E
Y
-
SSLG
GR
VN
E
G
T
E
H
E
V
VI
QES
VF
T
R
R
G
V
-----------------------
D
RI
L
R
Y
AFE
L
A
QS
R
P
R
KT
L
TS
AT
K
S
N
G
L
AI
S
MPY
W
D
E
R
V
EA
M
A
E
N
Y
--------------------
PEI
RWDKQH
ID
ILCA
R
F
V
MQ
P
E
R
FDV
V
V
A
SNLFGDILSD
LG
P
A
C
TG
T
IGIAPSANLN
P
E
RT
F
P
S
LFEP
V
HGSAPDI
Y
GKNIANPIA
T
I
WA
G
AMML
D
F
L
G
NG
D
E
R
FQQ
A
H
NG
I
LA
AIE
E
V
I
AH
G
PK
T
P
D
M-
K
---
G
N
A
--T
T
P
Q
V
A
DAI
C
K
II
fig|749538.3.peg.4411
Escherichia coli MS 116-1 (1-359/361)
M
M
K
T
MR
IA
A
IPGDGIG
K
EV
L
P
EG
IR
VL
Q
AA
A
ER
W
---
GFA
L
S
FEQMEW
A
SCE
Y
YSH
HG
K
M
--
M
P
DD
W
H
E
QLS
R
F
DA
IY
FG
A
VG
---
W
PDTV
PD
HI
S
LW
G
S
L
----
L
K
F
R
R
EFD
Q
Y
V
NLRPVRL
FP
G
V
P
--
CPL
-
A
G
K
Q
P
GDI
D
FYV
VRENTEG
E
Y
-
SSLG
GR
VN
E
G
T
E
H
E
V
VI
QES
VF
T
R
R
G
V
-----------------------
D
RI
L
R
Y
AFE
L
A
QS
R
P
R
KT
L
TS
AT
K
S
N
G
L
AI
S
MPY
W
D
E
R
V
EA
M
A
E
N
Y
--------------------
PEI
RWDKQH
ID
ILCA
R
F
V
MQ
P
E
R
FDV
V
V
A
SNLFGDILSD
LG
P
A
C
TG
T
IGIAPSANLN
P
E
RT
F
P
S
LFEP
V
HGSAPDI
Y
GKNIANPIA
T
I
WA
G
AMML
D
F
L
G
NG
D
E
R
FQQ
A
H
NG
I
LA
AIE
E
V
I
AH
G
PK
T
P
D
M-
K
---
G
N
A
--T
T
P
Q
V
A
DAI
C
K
II
fig|679206.4.peg.2926
Escherichia coli MS 119-7 (1-359/361)
M
M
K
T
MR
IA
A
IPGDGIG
K
EV
L
P
EG
IR
VL
Q
AA
A
ER
W
---
GFA
L
S
FEQMEW
A
SCE
Y
YSH
HG
K
M
--
M
P
DD
W
H
E
QLS
R
F
DA
IY
FG
A
VG
---
W
PDTV
PD
HI
S
LW
G
S
L
----
L
K
F
R
R
EFD
Q
Y
V
NLRPVRL
FP
G
V
P
--
CPL
-
A
G
K
Q
P
GDI
D
FYV
VRENTEG
E
Y
-
SSLG
GR
VN
E
G
T
E
H
E
V
VI
QES
VF
T
R
R
G
V
-----------------------
D
RI
L
R
Y
AFE
L
A
QS
R
P
R
KT
L
TS
AT
K
S
N
G
L
AI
S
MPY
W
D
E
R
V
EA
M
A
E
N
Y
--------------------
PEI
RWDKQH
ID
ILCA
R
F
V
MQ
P
E
R
FDV
V
V
A
SNLFGDILSD
LG
P
A
C
TG
T
IGIAPSANLN
P
E
RT
F
P
S
LFEP
V
HGSAPDI
Y
GKNIANPIA
T
I
WA
G
AMML
D
F
L
G
NG
D
E
R
FQQ
A
H
NG
I
LA
AIE
E
V
I
AH
G
PK
T
P
D
M-
K
---
G
N
A
--T
T
P
Q
V
A
DAI
C
K
II
fig|679205.4.peg.4355
Escherichia coli MS 124-1 (1-359/361)
M
M
K
T
MR
IA
A
IPGDGIG
K
EV
L
P
EG
IR
VL
Q
AA
A
ER
W
---
GFA
L
S
FEQMEW
A
SCE
Y
YSH
HG
K
M
--
M
P
DD
W
H
E
QLS
R
F
DA
IY
FG
A
VG
---
W
PDTV
PD
HI
S
LW
G
S
L
----
L
K
F
R
R
EFD
Q
Y
V
NLRPVRL
FP
G
V
P
--
CPL
-
A
G
K
Q
P
GDI
D
FYV
VRENTEG
E
Y
-
SSLG
GR
VN
E
G
T
E
H
E
V
VI
QES
VF
T
R
R
G
V
-----------------------
D
RI
L
R
Y
AFE
L
A
QS
R
P
R
KT
L
TS
AT
K
S
N
G
L
AI
S
MPY
W
D
E
R
V
EA
M
A
E
N
Y
--------------------
PEI
RWDKQH
ID
ILCA
R
F
V
MQ
P
E
R
FDV
V
V
A
SNLFGDILSD
LG
P
A
C
TG
T
IGIAPSANLN
P
E
RT
F
P
S
LFEP
V
HGSAPDI
Y
GKNIANPIA
T
I
WA
G
AMML
D
F
L
G
NG
D
E
R
FQQ
A
H
NG
I
LA
AIE
E
V
I
AH
G
PK
T
P
D
M-
K
---
G
N
A
--T
T
P
Q
V
A
DAI
C
K
II
fig|749540.3.peg.2207
Escherichia coli MS 146-1 (1-359/361)
M
M
K
T
MR
IA
A
IPGDGIG
K
EV
L
P
EG
IR
VL
Q
AA
A
ER
W
---
GFA
L
S
FEQMEW
A
SCE
Y
YSH
HG
K
M
--
M
P
DD
W
H
E
QLS
R
F
DA
IY
FG
A
VG
---
W
PDTV
PD
HI
S
LW
G
S
L
----
L
K
F
R
R
EFD
Q
Y
V
NLRPVRL
FP
G
V
P
--
CPL
-
A
G
K
Q
P
GDI
D
FYV
VRENTEG
E
Y
-
SSLG
GR
VN
E
G
T
E
H
E
V
VI
QES
VF
T
R
R
G
V
-----------------------
D
RI
L
R
Y
AFE
L
A
QS
R
P
R
KT
L
TS
AT
K
S
N
G
L
AI
S
MPY
W
D
E
R
V
EA
M
A
E
N
Y
--------------------
PEI
RWDKQH
ID
ILCA
R
F
V
MQ
P
E
R
FDV
V
V
A
SNLFGDILSD
LG
P
A
C
TG
T
IGIAPSANLN
P
E
RT
F
P
S
LFEP
V
HGSAPDI
Y
GKNIANPIA
T
I
WA
G
AMML
D
F
L
G
NG
D
E
R
FQQ
A
H
NG
I
LA
AIE
E
V
I
AH
G
PK
T
P
D
M-
K
---
G
N
A
--T
T
P
Q
V
A
DAI
C
K
II
fig|749544.3.peg.2277
Escherichia coli MS 175-1 (1-359/361)
M
M
K
T
MR
IA
A
IPGDGIG
K
EV
L
P
EG
IR
VL
Q
AA
A
ER
W
---
GFA
L
S
FEQMEW
A
SCE
Y
YSH
HG
K
M
--
M
P
DD
W
H
E
QLS
R
F
DA
IY
FG
A
VG
---
W
PDTV
PD
HI
S
LW
G
S
L
----
L
K
F
R
R
EFD
Q
Y
V
NLRPVRL
FP
G
V
P
--
CPL
-
A
G
K
Q
P
GDI
D
FYV
VRENTEG
E
Y
-
SSLG
GR
VN
E
G
T
E
H
E
V
VI
QES
VF
T
R
R
G
V
-----------------------
D
RI
L
R
Y
AFE
L
A
QS
R
P
R
KT
L
TS
AT
K
S
N
G
L
AI
S
MPY
W
D
E
R
V
EA
M
A
E
N
Y
--------------------
PEI
RWDKQH
ID
ILCA
R
F
V
MQ
P
E
R
FDV
V
V
A
SNLFGDILSD
LG
P
A
C
TG
T
IGIAPSANLN
P
E
RT
F
P
S
LFEP
V
HGSAPDI
Y
GKNIANPIA
T
I
WA
G
AMML
D
F
L
G
NG
D
E
R
FQQ
A
H
NG
I
LA
AIE
E
V
I
AH
G
PK
T
P
D
M-
K
---
G
N
A
--T
T
P
Q
V
A
DAI
C
K
II
fig|749545.3.peg.2847
Escherichia coli MS 182-1 (1-359/361)
M
M
K
T
MR
IA
A
IPGDGIG
K
EV
L
P
EG
IR
VL
Q
AA
A
ER
W
---
GFA
L
S
FEQMEW
A
SCE
Y
YSH
HG
K
M
--
M
P
DD
W
H
E
QLS
R
F
DA
IY
FG
A
VG
---
W
PDTV
PD
HI
S
LW
G
S
L
----
L
K
F
R
R
EFD
Q
Y
V
NLRPVRL
FP
G
V
P
--
CPL
-
A
G
K
Q
P
GDI
D
FYV
VRENTEG
E
Y
-
SSLG
GR
VN
E
G
T
E
H
E
V
VI
QES
VF
T
R
R
G
V
-----------------------
D
RI
L
R
Y
AFE
L
A
QS
R
P
R
KT
L
TS
AT
K
S
N
G
L
AI
S
MPY
W
D
E
R
V
EA
M
A
E
N
Y
--------------------
PEI
RWDKQH
ID
ILCA
R
F
V
MQ
P
E
R
FDV
V
V
A
SNLFGDILSD
LG
P
A
C
TG
T
IGIAPSANLN
P
E
RT
F
P
S
LFEP
V
HGSAPDI
Y
GKNIANPIA
T
I
WA
G
AMML
D
F
L
G
NG
D
E
R
FQQ
A
H
NG
I
LA
AIE
E
V
I
AH
G
PK
T
P
D
M-
K
---
G
N
A
--T
T
P
Q
V
A
DAI
C
K
II
fig|749548.3.peg.2539
Escherichia coli MS 196-1 (1-359/361)
M
M
K
T
MR
IA
A
IPGDGIG
K
EV
L
P
EG
IR
VL
Q
AA
A
ER
W
---
GFA
L
S
FEQMEW
A
SCE
Y
YSH
HG
K
M
--
M
P
DD
W
H
E
QLS
R
F
DA
IY
FG
A
VG
---
W
PDTV
PD
HI
S
LW
G
S
L
----
L
K
F
R
R
EFD
Q
Y
V
NLRPVRL
FP
G
V
P
--
CPL
-
A
G
K
Q
P
GDI
D
FYV
VRENTEG
E
Y
-
SSLG
GR
VN
E
G
T
E
H
E
V
VI
QES
VF
T
R
R
G
V
-----------------------
D
RI
L
R
Y
AFE
L
A
QS
R
P
R
KT
L
TS
AT
K
S
N
G
L
AI
S
MPY
W
D
E
R
V
EA
M
A
E
N
Y
--------------------
PEI
RWDKQH
ID
ILCA
R
F
V
MQ
P
E
R
FDV
V
V
A
SNLFGDILSD
LG
P
A
C
TG
T
IGIAPSANLN
P
E
RT
F
P
S
LFEP
V
HGSAPDI
Y
GKNIANPIA
T
I
WA
G
AMML
D
F
L
G
NG
D
E
R
FQQ
A
H
NG
I
LA
AIE
E
V
I
AH
G
PK
T
P
D
M-
K
---
G
N
A
--T
T
P
Q
V
A
DAI
C
K
II
fig|749533.3.peg.2766
Escherichia coli MS 84-1 (1-359/361)
M
M
K
T
MR
IA
A
IPGDGIG
K
EV
L
P
EG
IR
VL
Q
AA
A
ER
W
---
GFA
L
S
FEQMEW
A
SCE
Y
YSH
HG
K
M
--
M
P
DD
W
H
E
QLS
R
F
DA
IY
FG
A
VG
---
W
PDTV
PD
HI
S
LW
G
S
L
----
L
K
F
R
R
EFD
Q
Y
V
NLRPVRL
FP
G
V
P
--
CPL
-
A
G
K
Q
P
GDI
D
FYV
VRENTEG
E
Y
-
SSLG
GR
VN
E
G
T
E
H
E
V
VI
QES
VF
T
R
R
G
V
-----------------------
D
RI
L
R
Y
AFE
L
A
QS
R
P
R
KT
L
TS
AT
K
S
N
G
L
AI
S
MPY
W
D
E
R
V
EA
M
A
E
N
Y
--------------------
PEI
RWDKQH
ID
ILCA
R
F
V
MQ
P
E
R
FDV
V
V
A
SNLFGDILSD
LG
P
A
C
TG
T
IGIAPSANLN
P
E
RT
F
P
S
LFEP
V
HGSAPDI
Y
GKNIANPIA
T
I
WA
G
AMML
D
F
L
G
NG
D
E
R
FQQ
A
H
NG
I
LA
AIE
E
V
I
AH
G
PK
T
P
D
M-
K
---
G
N
A
--T
T
P
Q
V
A
DAI
C
K
II
fig|585396.4.peg.2396
Escherichia coli O111:H- str. 11128 (1-359/361)
M
M
K
T
MR
IA
A
IPGDGIG
K
EV
L
P
EG
IR
VL
Q
AA
A
ER
W
---
GFA
L
S
FEQMEW
A
SCE
Y
YSH
HG
K
M
--
M
P
DD
W
H
E
QLS
R
F
DA
IY
FG
A
VG
---
W
PDTV
PD
HI
S
LW
G
S
L
----
L
K
F
R
R
EFD
Q
Y
V
NLRPVRL
FP
G
V
P
--
CPL
-
A
G
K
Q
P
GDI
D
FYV
VRENTEG
E
Y
-
SSLG
GR
VN
E
G
T
E
H
E
V
VI
QES
VF
T
R
R
G
V
-----------------------
D
RI
L
R
Y
AFE
L
A
QS
R
P
R
KT
L
TS
AT
K
S
N
G
L
AI
S
MPY
W
D
E
R
V
EA
M
A
E
N
Y
--------------------
PEI
RWDKQH
ID
ILCA
R
F
V
MQ
P
E
R
FDV
V
V
A
SNLFGDILSD
LG
P
A
C
TG
T
IGIAPSANLN
P
E
RT
F
P
S
LFEP
V
HGSAPDI
Y
GKNIANPIA
T
I
WA
G
AMML
D
F
L
G
NG
D
E
R
FQQ
A
H
NG
I
LA
AIE
E
V
I
AH
G
PK
T
P
D
M-
K
---
G
N
A
--T
T
P
Q
V
A
DAI
C
K
II
fig|573235.3.peg.2612
Escherichia coli O26:H11 str. 11368 (1-359/361)
M
M
K
T
MR
IA
A
IPGDGIG
K
EV
L
P
EG
IR
VL
Q
AA
A
ER
W
---
GFA
L
S
FEQMEW
A
SCE
Y
YSH
HG
K
M
--
M
P
DD
W
H
E
QLS
R
F
DA
IY
FG
A
VG
---
W
PDTV
PD
HI
S
LW
G
S
L
----
L
K
F
R
R
EFD
Q
Y
V
NLRPVRL
FP
G
V
P
--
CPL
-
A
G
K
Q
P
GDI
D
FYV
VRENTEG
E
Y
-
SSLG
GR
VN
E
G
T
E
H
E
V
VI
QES
VF
T
R
R
G
V
-----------------------
D
RI
L
R
Y
AFE
L
A
QS
R
P
R
KT
L
TS
AT
K
S
N
G
L
AI
S
MPY
W
D
E
R
V
EA
M
A
E
N
Y
--------------------
PEI
RWDKQH
ID
ILCA
R
F
V
MQ
P
E
R
FDV
V
V
A
SNLFGDILSD
LG
P
A
C
TG
T
IGIAPSANLN
P
E
RT
F
P
S
LFEP
V
HGSAPDI
Y
GKNIANPIA
T
I
WA
G
AMML
D
F
L
G
NG
D
E
R
FQQ
A
H
NG
I
LA
AIE
E
V
I
AH
G
PK
T
P
D
M-
K
---
G
N
A
--T
T
P
Q
V
A
DAI
C
K
II
fig|409438.11.peg.2124
Escherichia coli SE11 (1-359/361)
M
M
K
T
MR
IA
A
IPGDGIG
K
EV
L
P
EG
IR
VL
Q
AA
A
ER
W
---
GFA
L
S
FEQMEW
A
SCE
Y
YSH
HG
K
M
--
M
P
DD
W
H
E
QLS
R
F
DA
IY
FG
A
VG
---
W
PDTV
PD
HI
S
LW
G
S
L
----
L
K
F
R
R
EFD
Q
Y
V
NLRPVRL
FP
G
V
P
--
CPL
-
A
G
K
Q
P
GDI
D
FYV
VRENTEG
E
Y
-
SSLG
GR
VN
E
G
T
E
H
E
V
VI
QES
VF
T
R
R
G
V
-----------------------
D
RI
L
R
Y
AFE
L
A
QS
R
P
R
KT
L
TS
AT
K
S
N
G
L
AI
S
MPY
W
D
E
R
V
EA
M
A
E
N
Y
--------------------
PEI
RWDKQH
ID
ILCA
R
F
V
MQ
P
E
R
FDV
V
V
A
SNLFGDILSD
LG
P
A
C
TG
T
IGIAPSANLN
P
E
RT
F
P
S
LFEP
V
HGSAPDI
Y
GKNIANPIA
T
I
WA
G
AMML
D
F
L
G
NG
D
E
R
FQQ
A
H
NG
I
LA
AIE
E
V
I
AH
G
PK
T
P
D
M-
K
---
G
N
A
--T
T
P
Q
V
A
DAI
C
K
II
fig|656444.3.peg.2723
Escherichia coli TA280 (1-359/361)
M
M
K
T
MR
IA
A
IPGDGIG
K
EV
L
P
EG
IR
VL
Q
AA
A
ER
W
---
GFA
L
S
FEQMEW
A
SCE
Y
YSH
HG
K
M
--
M
P
DD
W
H
E
QLS
R
F
DA
IY
FG
A
VG
---
W
PDTV
PD
HI
S
LW
G
S
L
----
L
K
F
R
R
EFD
Q
Y
V
NLRPVRL
FP
G
V
P
--
CPL
-
A
G
K
Q
P
GDI
D
FYV
VRENTEG
E
Y
-
SSLG
GR
VN
E
G
T
E
H
E
V
VI
QES
VF
T
R
R
G
V
-----------------------
D
RI
L
R
Y
AFE
L
A
QS
R
P
R
KT
L
TS
AT
K
S
N
G
L
AI
S
MPY
W
D
E
R
V
EA
M
A
E
N
Y
--------------------
PEI
RWDKQH
ID
ILCA
R
F
V
MQ
P
E
R
FDV
V
V
A
SNLFGDILSD
LG
P
A
C
TG
T
IGIAPSANLN
P
E
RT
F
P
S
LFEP
V
HGSAPDI
Y
GKNIANPIA
T
I
WA
G
AMML
D
F
L
G
NG
D
E
R
FQQ
A
H
NG
I
LA
AIE
E
V
I
AH
G
PK
T
P
D
M-
K
---
G
N
A
--T
T
P
Q
V
A
DAI
C
K
II
fig|566546.3.peg.4035
Escherichia coli W (1-359/361)
M
M
K
T
MR
IA
A
IPGDGIG
K
EV
L
P
EG
IR
VL
Q
AA
A
ER
W
---
GFA
L
S
FEQMEW
A
SCE
Y
YSH
HG
K
M
--
M
P
DD
W
H
E
QLS
R
F
DA
IY
FG
A
VG
---
W
PDTV
PD
HI
S
LW
G
S
L
----
L
K
F
R
R
EFD
Q
Y
V
NLRPVRL
FP
G
V
P
--
CPL
-
A
G
K
Q
P
GDI
D
FYV
VRENTEG
E
Y
-
SSLG
GR
VN
E
G
T
E
H
E
V
VI
QES
VF
T
R
R
G
V
-----------------------
D
RI
L
R
Y
AFE
L
A
QS
R
P
R
KT
L
TS
AT
K
S
N
G
L
AI
S
MPY
W
D
E
R
V
EA
M
A
E
N
Y
--------------------
PEI
RWDKQH
ID
ILCA
R
F
V
MQ
P
E
R
FDV
V
V
A
SNLFGDILSD
LG
P
A
C
TG
T
IGIAPSANLN
P
E
RT
F
P
S
LFEP
V
HGSAPDI
Y
GKNIANPIA
T
I
WA
G
AMML
D
F
L
G
NG
D
E
R
FQQ
A
H
NG
I
LA
AIE
E
V
I
AH
G
PK
T
P
D
M-
K
---
G
N
A
--T
T
P
Q
V
A
DAI
C
K
II
fig|566546.4.peg.1963
Escherichia coli W (1-359/361)
M
M
K
T
MR
IA
A
IPGDGIG
K
EV
L
P
EG
IR
VL
Q
AA
A
ER
W
---
GFA
L
S
FEQMEW
A
SCE
Y
YSH
HG
K
M
--
M
P
DD
W
H
E
QLS
R
F
DA
IY
FG
A
VG
---
W
PDTV
PD
HI
S
LW
G
S
L
----
L
K
F
R
R
EFD
Q
Y
V
NLRPVRL
FP
G
V
P
--
CPL
-
A
G
K
Q
P
GDI
D
FYV
VRENTEG
E
Y
-
SSLG
GR
VN
E
G
T
E
H
E
V
VI
QES
VF
T
R
R
G
V
-----------------------
D
RI
L
R
Y
AFE
L
A
QS
R
P
R
KT
L
TS
AT
K
S
N
G
L
AI
S
MPY
W
D
E
R
V
EA
M
A
E
N
Y
--------------------
PEI
RWDKQH
ID
ILCA
R
F
V
MQ
P
E
R
FDV
V
V
A
SNLFGDILSD
LG
P
A
C
TG
T
IGIAPSANLN
P
E
RT
F
P
S
LFEP
V
HGSAPDI
Y
GKNIANPIA
T
I
WA
G
AMML
D
F
L
G
NG
D
E
R
FQQ
A
H
NG
I
LA
AIE
E
V
I
AH
G
PK
T
P
D
M-
K
---
G
N
A
--T
T
P
Q
V
A
DAI
C
K
II
fig|316407.3.peg.1755
Escherichia coli W3110 (1-359/361)
M
M
K
T
MR
IA
A
IPGDGIG
K
EV
L
P
EG
IR
VL
Q
AA
A
ER
W
---
GFA
L
S
FEQMEW
A
SCE
Y
YSH
HG
K
M
--
M
P
DD
W
H
E
QLS
R
F
DA
IY
FG
A
VG
---
W
PDTV
PD
HI
S
LW
G
S
L
----
L
K
F
R
R
EFD
Q
Y
V
NLRPVRL
FP
G
V
P
--
CPL
-
A
G
K
Q
P
GDI
D
FYV
VRENTEG
E
Y
-
SSLG
GR
VN
E
G
T
E
H
E
V
VI
QES
VF
T
R
R
G
V
-----------------------
D
RI
L
R
Y
AFE
L
A
QS
R
P
R
KT
L
TS
AT
K
S
N
G
L
AI
S
MPY
W
D
E
R
V
EA
M
A
E
N
Y
--------------------
PEI
RWDKQH
ID
ILCA
R
F
V
MQ
P
E
R
FDV
V
V
A
SNLFGDILSD
LG
P
A
C
TG
T
IGIAPSANLN
P
E
RT
F
P
S
LFEP
V
HGSAPDI
Y
GKNIANPIA
T
I
WA
G
AMML
D
F
L
G
NG
D
E
R
FQQ
A
H
NG
I
LA
AIE
E
V
I
AH
G
PK
T
P
D
M-
K
---
G
N
A
--T
T
P
Q
V
A
DAI
C
K
II
fig|316385.5.peg.1919
Escherichia coli str. K-12 substr. DH10B (1-359/361)
M
M
K
T
MR
IA
A
IPGDGIG
K
EV
L
P
EG
IR
VL
Q
AA
A
ER
W
---
GFA
L
S
FEQMEW
A
SCE
Y
YSH
HG
K
M
--
M
P
DD
W
H
E
QLS
R
F
DA
IY
FG
A
VG
---
W
PDTV
PD
HI
S
LW
G
S
L
----
L
K
F
R
R
EFD
Q
Y
V
NLRPVRL
FP
G
V
P
--
CPL
-
A
G
K
Q
P
GDI
D
FYV
VRENTEG
E
Y
-
SSLG
GR
VN
E
G
T
E
H
E
V
VI
QES
VF
T
R
R
G
V
-----------------------
D
RI
L
R
Y
AFE
L
A
QS
R
P
R
KT
L
TS
AT
K
S
N
G
L
AI
S
MPY
W
D
E
R
V
EA
M
A
E
N
Y
--------------------
PEI
RWDKQH
ID
ILCA
R
F
V
MQ
P
E
R
FDV
V
V
A
SNLFGDILSD
LG
P
A
C
TG
T
IGIAPSANLN
P
E
RT
F
P
S
LFEP
V
HGSAPDI
Y
GKNIANPIA
T
I
WA
G
AMML
D
F
L
G
NG
D
E
R
FQQ
A
H
NG
I
LA
AIE
E
V
I
AH
G
PK
T
P
D
M-
K
---
G
N
A
--T
T
P
Q
V
A
DAI
C
K
II
fig|316385.7.peg.1964
Escherichia coli str. K-12 substr. DH10B (1-359/361)
M
M
K
T
MR
IA
A
IPGDGIG
K
EV
L
P
EG
IR
VL
Q
AA
A
ER
W
---
GFA
L
S
FEQMEW
A
SCE
Y
YSH
HG
K
M
--
M
P
DD
W
H
E
QLS
R
F
DA
IY
FG
A
VG
---
W
PDTV
PD
HI
S
LW
G
S
L
----
L
K
F
R
R
EFD
Q
Y
V
NLRPVRL
FP
G
V
P
--
CPL
-
A
G
K
Q
P
GDI
D
FYV
VRENTEG
E
Y
-
SSLG
GR
VN
E
G
T
E
H
E
V
VI
QES
VF
T
R
R
G
V
-----------------------
D
RI
L
R
Y
AFE
L
A
QS
R
P
R
KT
L
TS
AT
K
S
N
G
L
AI
S
MPY
W
D
E
R
V
EA
M
A
E
N
Y
--------------------
PEI
RWDKQH
ID
ILCA
R
F
V
MQ
P
E
R
FDV
V
V
A
SNLFGDILSD
LG
P
A
C
TG
T
IGIAPSANLN
P
E
RT
F
P
S
LFEP
V
HGSAPDI
Y
GKNIANPIA
T
I
WA
G
AMML
D
F
L
G
NG
D
E
R
FQQ
A
H
NG
I
LA
AIE
E
V
I
AH
G
PK
T
P
D
M-
K
---
G
N
A
--T
T
P
Q
V
A
DAI
C
K
II
fig|511145.12.peg.1876
Escherichia coli str. K-12 substr. MG1655 (1-359/361)
M
M
K
T
MR
IA
A
IPGDGIG
K
EV
L
P
EG
IR
VL
Q
AA
A
ER
W
---
GFA
L
S
FEQMEW
A
SCE
Y
YSH
HG
K
M
--
M
P
DD
W
H
E
QLS
R
F
DA
IY
FG
A
VG
---
W
PDTV
PD
HI
S
LW
G
S
L
----
L
K
F
R
R
EFD
Q
Y
V
NLRPVRL
FP
G
V
P
--
CPL
-
A
G
K
Q
P
GDI
D
FYV
VRENTEG
E
Y
-
SSLG
GR
VN
E
G
T
E
H
E
V
VI
QES
VF
T
R
R
G
V
-----------------------
D
RI
L
R
Y
AFE
L
A
QS
R
P
R
KT
L
TS
AT
K
S
N
G
L
AI
S
MPY
W
D
E
R
V
EA
M
A
E
N
Y
--------------------
PEI
RWDKQH
ID
ILCA
R
F
V
MQ
P
E
R
FDV
V
V
A
SNLFGDILSD
LG
P
A
C
TG
T
IGIAPSANLN
P
E
RT
F
P
S
LFEP
V
HGSAPDI
Y
GKNIANPIA
T
I
WA
G
AMML
D
F
L
G
NG
D
E
R
FQQ
A
H
NG
I
LA
AIE
E
V
I
AH
G
PK
T
P
D
M-
K
---
G
N
A
--T
T
P
Q
V
A
DAI
C
K
II
fig|511145.6.peg.1860
Escherichia coli str. K-12 substr. MG1655 (1-359/361)
M
M
K
T
MR
IA
A
IPGDGIG
K
EV
L
P
EG
IR
VL
Q
AA
A
ER
W
---
GFA
L
S
FEQMEW
A
SCE
Y
YSH
HG
K
M
--
M
P
DD
W
H
E
QLS
R
F
DA
IY
FG
A
VG
---
W
PDTV
PD
HI
S
LW
G
S
L
----
L
K
F
R
R
EFD
Q
Y
V
NLRPVRL
FP
G
V
P
--
CPL
-
A
G
K
Q
P
GDI
D
FYV
VRENTEG
E
Y
-
SSLG
GR
VN
E
G
T
E
H
E
V
VI
QES
VF
T
R
R
G
V
-----------------------
D
RI
L
R
Y
AFE
L
A
QS
R
P
R
KT
L
TS
AT
K
S
N
G
L
AI
S
MPY
W
D
E
R
V
EA
M
A
E
N
Y
--------------------
PEI
RWDKQH
ID
ILCA
R
F
V
MQ
P
E
R
FDV
V
V
A
SNLFGDILSD
LG
P
A
C
TG
T
IGIAPSANLN
P
E
RT
F
P
S
LFEP
V
HGSAPDI
Y
GKNIANPIA
T
I
WA
G
AMML
D
F
L
G
NG
D
E
R
FQQ
A
H
NG
I
LA
AIE
E
V
I
AH
G
PK
T
P
D
M-
K
---
G
N
A
--T
T
P
Q
V
A
DAI
C
K
II
fig|340185.3.peg.4727
Escherichia coli E22 (1-359/361)
M
M
K
T
MR
IA
A
IPGDGIG
K
EV
L
P
EG
IR
VL
Q
AA
A
ER
W
---
GFD
L
S
FEQMEW
A
SCE
Y
YSH
HG
K
M
--
M
P
DD
W
H
E
QLS
R
F
DA
IY
FG
A
VG
---
W
PDTV
PD
HI
S
LW
G
S
L
----
L
K
F
R
R
EFD
Q
Y
V
NLRPVRL
FP
G
V
P
--
CPL
-
A
G
K
Q
P
GDI
D
FYV
VRENTEG
E
Y
-
SSLG
GR
VN
E
G
T
E
H
E
V
VI
QES
VF
T
R
R
G
V
-----------------------
D
RI
L
R
Y
AFE
L
A
QS
R
P
R
KT
L
TS
AT
K
S
N
G
L
AI
S
MPY
W
D
E
R
V
EA
M
A
E
N
Y
--------------------
PEI
RWDKQH
ID
ILCA
R
F
V
MQ
P
E
R
FDV
V
V
A
SNLFGDILSD
LG
P
A
C
TG
T
IGIAPSANLN
P
E
RT
F
P
S
LFEP
V
HGSAPDI
Y
GKNIANPIA
T
I
WA
G
AMML
D
F
L
G
NG
D
E
R
FQQ
A
H
NG
I
LA
AIE
E
V
I
AH
G
PK
T
P
D
M-
K
---
G
N
A
--T
T
P
Q
V
A
DAI
C
K
II
fig|340185.4.peg.4994
Escherichia coli E22 (1-359/361)
M
M
K
T
MR
IA
A
IPGDGIG
K
EV
L
P
EG
IR
VL
Q
AA
A
ER
W
---
GFD
L
S
FEQMEW
A
SCE
Y
YSH
HG
K
M
--
M
P
DD
W
H
E
QLS
R
F
DA
IY
FG
A
VG
---
W
PDTV
PD
HI
S
LW
G
S
L
----
L
K
F
R
R
EFD
Q
Y
V
NLRPVRL
FP
G
V
P
--
CPL
-
A
G
K
Q
P
GDI
D
FYV
VRENTEG
E
Y
-
SSLG
GR
VN
E
G
T
E
H
E
V
VI
QES
VF
T
R
R
G
V
-----------------------
D
RI
L
R
Y
AFE
L
A
QS
R
P
R
KT
L
TS
AT
K
S
N
G
L
AI
S
MPY
W
D
E
R
V
EA
M
A
E
N
Y
--------------------
PEI
RWDKQH
ID
ILCA
R
F
V
MQ
P
E
R
FDV
V
V
A
SNLFGDILSD
LG
P
A
C
TG
T
IGIAPSANLN
P
E
RT
F
P
S
LFEP
V
HGSAPDI
Y
GKNIANPIA
T
I
WA
G
AMML
D
F
L
G
NG
D
E
R
FQQ
A
H
NG
I
LA
AIE
E
V
I
AH
G
PK
T
P
D
M-
K
---
G
N
A
--T
T
P
Q
V
A
DAI
C
K
II
fig|585034.4.peg.1844
Escherichia coli IAI1 (1-359/361)
M
M
K
T
MR
IA
A
IPGDGIG
K
EV
L
P
EG
IR
VL
Q
AA
A
ER
W
---
GFD
L
S
FEQMEW
A
SCE
Y
YSH
HG
K
M
--
M
P
DD
W
H
E
QLS
R
F
DA
IY
FG
A
VG
---
W
PDTV
PD
HI
S
LW
G
S
L
----
L
K
F
R
R
EFD
Q
Y
V
NLRPVRL
FP
G
V
P
--
CPL
-
A
G
K
Q
P
GDI
D
FYV
VRENTEG
E
Y
-
SSLG
GR
VN
E
G
T
E
H
E
V
VI
QES
VF
T
R
R
G
V
-----------------------
D
RI
L
R
Y
AFE
L
A
QS
R
P
R
KT
L
TS
AT
K
S
N
G
L
AI
S
MPY
W
D
E
R
V
EA
M
A
E
N
Y
--------------------
PEI
RWDKQH
ID
ILCA
R
F
V
MQ
P
E
R
FDV
V
V
A
SNLFGDILSD
LG
P
A
C
TG
T
IGIAPSANLN
P
E
RT
F
P
S
LFEP
V
HGSAPDI
Y
GKNIANPIA
T
I
WA
G
AMML
D
F
L
G
NG
D
E
R
FQQ
A
H
NG
I
LA
AIE
E
V
I
AH
G
PK
T
P
D
M-
K
---
G
N
A
--T
T
P
Q
V
A
DAI
C
K
II
fig|585034.5.peg.1840
Escherichia coli IAI1 (1-359/361)
M
M
K
T
MR
IA
A
IPGDGIG
K
EV
L
P
EG
IR
VL
Q
AA
A
ER
W
---
GFD
L
S
FEQMEW
A
SCE
Y
YSH
HG
K
M
--
M
P
DD
W
H
E
QLS
R
F
DA
IY
FG
A
VG
---
W
PDTV
PD
HI
S
LW
G
S
L
----
L
K
F
R
R
EFD
Q
Y
V
NLRPVRL
FP
G
V
P
--
CPL
-
A
G
K
Q
P
GDI
D
FYV
VRENTEG
E
Y
-
SSLG
GR
VN
E
G
T
E
H
E
V
VI
QES
VF
T
R
R
G
V
-----------------------
D
RI
L
R
Y
AFE
L
A
QS
R
P
R
KT
L
TS
AT
K
S
N
G
L
AI
S
MPY
W
D
E
R
V
EA
M
A
E
N
Y
--------------------
PEI
RWDKQH
ID
ILCA
R
F
V
MQ
P
E
R
FDV
V
V
A
SNLFGDILSD
LG
P
A
C
TG
T
IGIAPSANLN
P
E
RT
F
P
S
LFEP
V
HGSAPDI
Y
GKNIANPIA
T
I
WA
G
AMML
D
F
L
G
NG
D
E
R
FQQ
A
H
NG
I
LA
AIE
E
V
I
AH
G
PK
T
P
D
M-
K
---
G
N
A
--T
T
P
Q
V
A
DAI
C
K
II
fig|585395.4.peg.2085
Escherichia coli O103:H2 str. 12009 (1-359/361)
M
M
K
T
MR
IA
A
IPGDGIG
K
EV
L
P
EG
IR
VL
Q
AA
A
ER
W
---
GFD
L
S
FEQMEW
A
SCE
Y
YSH
HG
K
M
--
M
P
DD
W
H
E
QLS
R
F
DA
IY
FG
A
VG
---
W
PDTV
PD
HI
S
LW
G
S
L
----
L
K
F
R
R
EFD
Q
Y
V
NLRPVRL
FP
G
V
P
--
CPL
-
A
G
K
Q
P
GDI
D
FYV
VRENTEG
E
Y
-
SSLG
GR
VN
E
G
T
E
H
E
V
VI
QES
VF
T
R
R
G
V
-----------------------
D
RI
L
R
Y
AFE
L
A
QS
R
P
R
KT
L
TS
AT
K
S
N
G
L
AI
S
MPY
W
D
E
R
V
EA
M
A
E
N
Y
--------------------
PEI
RWDKQH
ID
ILCA
R
F
V
MQ
P
E
R
FDV
V
V
A
SNLFGDILSD
LG
P
A
C
TG
T
IGIAPSANLN
P
E
RT
F
P
S
LFEP
V
HGSAPDI
Y
GKNIANPIA
T
I
WA
G
AMML
D
F
L
G
NG
D
E
R
FQQ
A
H
NG
I
LA
AIE
E
V
I
AH
G
PK
T
P
D
M-
K
---
G
N
A
--T
T
P
Q
V
A
DAI
C
K
II
fig|656443.3.peg.2479
Escherichia coli TA271 (1-359/361)
M
M
K
T
MR
IA
A
IPGDGIG
K
EV
L
P
EG
IR
VL
Q
AA
A
ER
W
---
GFD
L
S
FEQMEW
A
SCE
Y
YSH
HG
K
M
--
M
P
DD
W
H
E
QLS
R
F
DA
IY
FG
A
VG
---
W
PDTV
PD
HI
S
LW
G
S
L
----
L
K
F
R
R
EFD
Q
Y
V
NLRPVRL
FP
G
V
P
--
CPL
-
A
G
K
Q
P
GDI
D
FYV
VRENTEG
E
Y
-
SSLG
GR
VN
E
G
T
E
H
E
V
VI
QES
VF
T
R
R
G
V
-----------------------
D
RI
L
R
Y
AFE
L
A
QS
R
P
R
KT
L
TS
AT
K
S
N
G
L
AI
S
MPY
W
D
E
R
V
EA
M
A
E
N
Y
--------------------
PEI
RWDKQH
ID
ILCA
R
F
V
MQ
P
E
R
FDV
V
V
A
SNLFGDILSD
LG
P
A
C
TG
T
IGIAPSANLN
P
E
RT
F
P
S
LFEP
V
HGSAPDI
Y
GKNIANPIA
T
I
WA
G
AMML
D
F
L
G
NG
D
E
R
FQQ
A
H
NG
I
LA
AIE
E
V
I
AH
G
PK
T
P
D
M-
K
---
G
N
A
--T
T
P
Q
V
A
DAI
C
K
II
fig|344601.3.peg.4350
Escherichia coli B171 (1-359/361)
M
M
K
T
MR
IA
A
IPGDGIG
K
EV
L
P
EG
IR
VL
Q
AA
A
ER
W
---
GFY
L
S
FEQMEW
A
SCE
Y
YSH
HG
K
M
--
M
P
DD
W
H
E
QLS
R
F
DA
IY
FG
A
VG
---
W
PDTV
PD
HI
S
LW
G
S
L
----
L
K
F
R
R
EFD
Q
Y
V
NLRPVRL
FP
G
V
P
--
CPL
-
A
G
K
Q
P
GDI
D
FYV
VRENTEG
E
Y
-
SSLG
GR
VN
E
G
T
E
H
E
V
VI
QES
VF
T
R
R
G
V
-----------------------
D
RI
L
R
Y
AFE
L
A
QS
R
P
R
KT
L
TS
AT
K
S
N
G
L
AI
S
MPY
W
D
E
R
V
EA
M
A
E
N
Y
--------------------
PEI
RWDKQH
ID
ILCA
R
F
V
MQ
P
E
R
FDV
V
V
A
SNLFGDILSD
LG
P
A
C
TG
T
IGIAPSANLN
P
E
RT
F
P
S
LFEP
V
HGSAPDI
Y
GKNIANPIA
T
I
WA
G
AMML
D
F
L
G
NG
D
E
R
FQQ
A
H
NG
I
LA
AIE
E
V
I
AH
G
PK
T
P
D
M-
K
---
G
N
A
--T
T
P
Q
V
A
DAI
C
K
II
fig|344601.5.peg.4584
Escherichia coli B171 (1-359/361)
M
M
K
T
MR
IA
A
IPGDGIG
K
EV
L
P
EG
IR
VL
Q
AA
A
ER
W
---
GFY
L
S
FEQMEW
A
SCE
Y
YSH
HG
K
M
--
M
P
DD
W
H
E
QLS
R
F
DA
IY
FG
A
VG
---
W
PDTV
PD
HI
S
LW
G
S
L
----
L
K
F
R
R
EFD
Q
Y
V
NLRPVRL
FP
G
V
P
--
CPL
-
A
G
K
Q
P
GDI
D
FYV
VRENTEG
E
Y
-
SSLG
GR
VN
E
G
T
E
H
E
V
VI
QES
VF
T
R
R
G
V
-----------------------
D
RI
L
R
Y
AFE
L
A
QS
R
P
R
KT
L
TS
AT
K
S
N
G
L
AI
S
MPY
W
D
E
R
V
EA
M
A
E
N
Y
--------------------
PEI
RWDKQH
ID
ILCA
R
F
V
MQ
P
E
R
FDV
V
V
A
SNLFGDILSD
LG
P
A
C
TG
T
IGIAPSANLN
P
E
RT
F
P
S
LFEP
V
HGSAPDI
Y
GKNIANPIA
T
I
WA
G
AMML
D
F
L
G
NG
D
E
R
FQQ
A
H
NG
I
LA
AIE
E
V
I
AH
G
PK
T
P
D
M-
K
---
G
N
A
--T
T
P
Q
V
A
DAI
C
K
II
fig|656379.3.peg.2277
Escherichia coli FVEC1302 (1-359/361)
M
M
K
T
MR
IA
A
IPGDGIG
R
EV
L
P
EG
IR
VL
Q
AA
A
ER
W
---
GFA
L
S
FEQMEW
A
SCE
Y
YSH
HG
K
M
--
M
P
DD
W
H
E
QLS
R
F
DA
IY
FG
A
VG
---
W
PDTV
PD
HI
S
LW
G
S
L
----
L
K
F
R
R
EFD
Q
Y
V
NLRPVRL
FP
G
V
P
--
CPL
-
A
G
K
Q
P
GDI
D
FYV
VRENTEG
E
Y
-
SSLG
GR
VN
E
G
T
E
H
E
V
VI
QES
VF
T
R
R
G
V
-----------------------
D
RI
L
R
Y
AFE
L
A
QS
R
P
R
KT
L
TS
AT
K
S
N
G
L
AI
S
MPY
W
D
E
R
V
EA
M
A
E
N
Y
--------------------
PEI
RWDKQH
ID
ILCA
R
F
V
MQ
P
E
R
FDV
V
V
A
SNLFGDILSD
LG
P
A
C
TG
T
IGIAPSANLN
P
E
RT
F
P
S
LFEP
V
HGSAPDI
Y
GKNIANPIA
T
I
WA
G
AMML
D
F
L
G
NG
D
E
R
FQQ
A
H
NG
I
LA
AIE
E
V
I
AH
G
PK
T
P
D
M-
K
---
G
N
A
--T
T
P
Q
V
A
DAI
C
K
II
fig|656380.3.peg.3241
Escherichia coli FVEC1412 (1-359/361)
M
M
K
T
MR
IA
A
IPGDGIG
R
EV
L
P
EG
IR
VL
Q
AA
A
ER
W
---
GFA
L
S
FEQMEW
A
SCE
Y
YSH
HG
K
M
--
M
P
DD
W
H
E
QLS
R
F
DA
IY
FG
A
VG
---
W
PDTV
PD
HI
S
LW
G
S
L
----
L
K
F
R
R
EFD
Q
Y
V
NLRPVRL
FP
G
V
P
--
CPL
-
A
G
K
Q
P
GDI
D
FYV
VRENTEG
E
Y
-
SSLG
GR
VN
E
G
T
E
H
E
V
VI
QES
VF
T
R
R
G
V
-----------------------
D
RI
L
R
Y
AFE
L
A
QS
R
P
R
KT
L
TS
AT
K
S
N
G
L
AI
S
MPY
W
D
E
R
V
EA
M
A
E
N
Y
--------------------
PEI
RWDKQH
ID
ILCA
R
F
V
MQ
P
E
R
FDV
V
V
A
SNLFGDILSD
LG
P
A
C
TG
T
IGIAPSANLN
P
E
RT
F
P
S
LFEP
V
HGSAPDI
Y
GKNIANPIA
T
I
WA
G
AMML
D
F
L
G
NG
D
E
R
FQQ
A
H
NG
I
LA
AIE
E
V
I
AH
G
PK
T
P
D
M-
K
---
G
N
A
--T
T
P
Q
V
A
DAI
C
K
II
fig|749549.3.peg.3071
Escherichia coli MS 198-1 (1-359/361)
M
M
K
T
MR
IA
A
IPGDGIG
R
EV
L
P
EG
IR
VL
Q
AA
A
ER
W
---
GFA
L
S
FEQMEW
A
SCE
Y
YSH
HG
K
M
--
M
P
DD
W
H
E
QLS
R
F
DA
IY
FG
A
VG
---
W
PDTV
PD
HI
S
LW
G
S
L
----
L
K
F
R
R
EFD
Q
Y
V
NLRPVRL
FP
G
V
P
--
CPL
-
A
G
K
Q
P
GDI
D
FYV
VRENTEG
E
Y
-
SSLG
GR
VN
E
G
T
E
H
E
V
VI
QES
VF
T
R
R
G
V
-----------------------
D
RI
L
R
Y
AFE
L
A
QS
R
P
R
KT
L
TS
AT
K
S
N
G
L
AI
S
MPY
W
D
E
R
V
EA
M
A
E
N
Y
--------------------
PEI
RWDKQH
ID
ILCA
R
F
V
MQ
P
E
R
FDV
V
V
A
SNLFGDILSD
LG
P
A
C
TG
T
IGIAPSANLN
P
E
RT
F
P
S
LFEP
V
HGSAPDI
Y
GKNIANPIA
T
I
WA
G
AMML
D
F
L
G
NG
D
E
R
FQQ
A
H
NG
I
LA
AIE
E
V
I
AH
G
PK
T
P
D
M-
K
---
G
N
A
--T
T
P
Q
V
A
DAI
C
K
II
fig|585056.7.peg.2278
Escherichia coli UMN026 (1-359/361)
M
M
K
T
MR
IA
A
IPGDGIG
R
EV
L
P
EG
IR
VL
Q
AA
A
ER
W
---
GFA
L
S
FEQMEW
A
SCE
Y
YSH
HG
K
M
--
M
P
DD
W
H
E
QLS
R
F
DA
IY
FG
A
VG
---
W
PDTV
PD
HI
S
LW
G
S
L
----
L
K
F
R
R
EFD
Q
Y
V
NLRPVRL
FP
G
V
P
--
CPL
-
A
G
K
Q
P
GDI
D
FYV
VRENTEG
E
Y
-
SSLG
GR
VN
E
G
T
E
H
E
V
VI
QES
VF
T
R
R
G
V
-----------------------
D
RI
L
R
Y
AFE
L
A
QS
R
P
R
KT
L
TS
AT
K
S
N
G
L
AI
S
MPY
W
D
E
R
V
EA
M
A
E
N
Y
--------------------
PEI
RWDKQH
ID
ILCA
R
F
V
MQ
P
E
R
FDV
V
V
A
SNLFGDILSD
LG
P
A
C
TG
T
IGIAPSANLN
P
E
RT
F
P
S
LFEP
V
HGSAPDI
Y
GKNIANPIA
T
I
WA
G
AMML
D
F
L
G
NG
D
E
R
FQQ
A
H
NG
I
LA
AIE
E
V
I
AH
G
PK
T
P
D
M-
K
---
G
N
A
--T
T
P
Q
V
A
DAI
C
K
II
fig|749532.3.peg.2297
Escherichia coli MS 78-1 (1-359/361)
M
M
K
T
MR
IA
A
IPGDGIG
K
EV
L
P
EG
IR
VL
Q
AA
A
ER
W
---
GFA
L
S
FEQMEW
A
SCE
Y
YSH
HG
K
M
--
M
P
DD
W
H
E
QLS
R
F
DA
IY
FG
A
VG
---
W
PDTV
PD
HI
S
LW
G
S
L
----
L
K
F
R
R
EFD
Q
Y
V
NLRPVRL
FP
G
V
P
--
CPL
-
A
G
K
Q
P
GDI
D
FYV
VRENTEG
E
Y
-
SSLG
GR
VN
E
G
T
E
H
E
V
VI
QES
VF
T
R
R
G
V
-----------------------
D
RI
L
R
Y
AFE
L
A
QS
R
P
R
KT
L
TS
AT
K
S
N
G
L
AI
S
MPY
W
D
E
R
V
EA
M
A
E
N
Y
--------------------
PEI
RWDKQH
ID
ILCA
R
F
V
MQ
P
E
R
FDV
V
V
A
SNLFGDILSD
LG
P
A
C
TG
T
IGIAPSANLN
P
E
RT
F
P
P
LFEP
V
HGSAPDI
Y
GKNIANPIA
T
I
WA
G
AMML
D
F
L
G
NG
D
E
R
FQQ
A
H
NG
I
LA
AIE
E
V
I
AH
G
PK
T
P
D
M-
K
---
G
N
A
--T
T
P
Q
V
A
DAI
C
K
II
fig|585057.4.peg.1311
Escherichia coli IAI39 (1-359/361)
M
M
K
T
MR
IA
A
IPGDGIG
K
EV
L
P
EG
IR
VL
Q
AA
A
ER
W
---
GFA
L
S
FEQMEW
A
SCE
Y
YSH
HG
K
M
--
M
P
DD
W
H
E
QLS
R
F
DA
IY
FG
A
VG
---
W
PDTV
PD
HI
S
LW
G
S
L
----
L
K
F
R
R
EFD
Q
Y
V
NLRPVRL
FP
G
V
P
--
CPL
-
A
G
K
Q
P
GDI
D
FYV
VRENTEG
E
Y
-
SSLG
GR
VN
E
G
T
E
H
E
V
VI
QES
VF
T
R
R
G
V
-----------------------
D
RI
L
R
Y
AFE
L
A
QS
R
P
R
KT
L
TS
AT
K
S
N
G
L
AI
S
MPY
W
D
E
R
V
EA
M
A
E
N
Y
--------------------
PEI
CWDKQH
ID
ILCA
R
F
V
MQ
P
E
R
FDV
V
V
A
SNLFGDILSD
LG
P
A
C
TG
T
IGIAPSANLN
P
E
RT
F
P
S
LFEP
V
HGSAPDI
Y
GKNIANPIA
T
I
WA
G
AMML
D
F
L
G
NG
D
E
R
FQQ
A
H
NG
I
LA
AIE
E
V
I
AH
G
PK
T
P
D
M-
K
---
G
N
A
--T
T
P
Q
V
A
DAI
C
K
II
fig|585057.6.peg.1310
Escherichia coli IAI39 (1-359/361)
M
M
K
T
MR
IA
A
IPGDGIG
K
EV
L
P
EG
IR
VL
Q
AA
A
ER
W
---
GFA
L
S
FEQMEW
A
SCE
Y
YSH
HG
K
M
--
M
P
DD
W
H
E
QLS
R
F
DA
IY
FG
A
VG
---
W
PDTV
PD
HI
S
LW
G
S
L
----
L
K
F
R
R
EFD
Q
Y
V
NLRPVRL
FP
G
V
P
--
CPL
-
A
G
K
Q
P
GDI
D
FYV
VRENTEG
E
Y
-
SSLG
GR
VN
E
G
T
E
H
E
V
VI
QES
VF
T
R
R
G
V
-----------------------
D
RI
L
R
Y
AFE
L
A
QS
R
P
R
KT
L
TS
AT
K
S
N
G
L
AI
S
MPY
W
D
E
R
V
EA
M
A
E
N
Y
--------------------
PEI
CWDKQH
ID
ILCA
R
F
V
MQ
P
E
R
FDV
V
V
A
SNLFGDILSD
LG
P
A
C
TG
T
IGIAPSANLN
P
E
RT
F
P
S
LFEP
V
HGSAPDI
Y
GKNIANPIA
T
I
WA
G
AMML
D
F
L
G
NG
D
E
R
FQQ
A
H
NG
I
LA
AIE
E
V
I
AH
G
PK
T
P
D
M-
K
---
G
N
A
--T
T
P
Q
V
A
DAI
C
K
II
fig|749527.3.peg.3627
Escherichia coli MS 21-1 (1-359/361)
M
M
K
T
MR
IA
A
IPGDGIG
K
EV
L
P
EG
IR
VL
Q
AA
A
ER
W
---
GFA
L
S
FEQMEW
A
SCE
Y
YSH
HG
K
M
--
M
P
DD
W
H
E
QLS
R
F
DA
IY
FG
A
VG
---
W
PDTV
PD
HI
S
LW
G
S
L
----
L
K
F
R
R
EFD
Q
Y
V
NLRPVRL
FP
G
V
P
--
CPL
-
A
G
K
Q
P
GDI
D
FYV
VRENTEG
E
Y
-
SSLG
GR
VN
E
G
T
E
H
E
V
VI
QES
VF
T
R
R
G
V
-----------------------
D
RI
L
R
Y
AFE
L
A
QS
R
P
R
KT
L
TS
AT
K
S
N
G
L
AI
S
MPY
W
D
E
R
V
EA
M
A
E
N
Y
--------------------
PEI
CWDKQH
ID
ILCA
R
F
V
MQ
P
E
R
FDV
V
V
A
SNLFGDILSD
LG
P
A
C
TG
T
IGIAPSANLN
P
E
RT
F
P
S
LFEP
V
HGSAPDI
Y
GKNIANPIA
T
I
WA
G
AMML
D
F
L
G
NG
D
E
R
FQQ
A
H
NG
I
LA
AIE
E
V
I
AH
G
PK
T
P
D
M-
K
---
G
N
A
--T
T
P
Q
V
A
DAI
C
K
II
fig|749531.3.peg.4714
Escherichia coli MS 69-1 (1-359/361)
M
M
K
T
MR
IA
A
IPGDGIG
K
EV
L
P
EG
IR
VL
Q
AA
A
ER
W
---
GFA
L
S
FEQMEW
A
SCE
Y
YSH
HG
K
M
--
M
P
DD
W
H
E
QLS
R
F
DA
IY
FG
A
VG
---
W
PDTV
PD
HI
S
LW
G
S
L
----
L
K
F
R
R
EFD
Q
Y
V
NLRPVRL
FP
G
V
P
--
CPL
-
A
G
K
Q
P
GDI
D
FYV
VRENTEG
E
Y
-
SSLG
GR
VN
E
G
T
E
H
E
V
VI
QES
VF
T
R
R
G
V
-----------------------
D
RI
L
R
Y
AFE
L
A
QS
R
P
R
KT
L
TS
AT
K
S
N
G
L
AI
S
MPY
W
D
E
R
V
EA
M
A
E
N
Y
--------------------
PEI
CWDKQH
ID
ILCA
R
F
V
MQ
P
E
R
FDV
V
V
A
SNLFGDILSD
LG
P
A
C
TG
T
IGIAPSANLN
P
E
RT
F
P
S
LFEP
V
HGSAPDI
Y
GKNIANPIA
T
I
WA
G
AMML
D
F
L
G
NG
D
E
R
FQQ
A
H
NG
I
LA
AIE
E
V
I
AH
G
PK
T
P
D
M-
K
---
G
N
A
--T
T
P
Q
V
A
DAI
C
K
II
fig|439855.10.peg.1547
Escherichia coli SMS-3-5 (1-359/361)
M
M
K
T
IR
IA
A
IPGDGIG
K
EV
L
P
EG
IR
VL
K
AA
A
ER
W
---
GFA
L
S
FEQMEW
A
SCE
Y
YSH
HG
K
M
--
M
P
DD
W
H
E
QLS
R
F
DA
IY
FG
A
VG
---
W
PDTV
PD
HI
S
LW
G
S
L
----
L
K
F
R
R
EFD
Q
Y
V
NLRPVRL
FP
G
V
P
--
CPL
-
A
G
K
Q
P
GDI
D
FYV
VRENTEG
E
Y
-
SSLG
GR
VN
E
G
T
E
H
E
V
VI
QES
VF
T
R
R
G
V
-----------------------
D
RI
L
R
Y
AFE
L
A
QS
R
P
R
KT
L
TS
AT
K
S
N
G
L
AI
S
MPY
W
D
E
R
V
EA
M
A
E
N
Y
--------------------
PEI
CWDKQH
ID
ILCA
R
F
V
MQ
P
E
R
FDV
V
V
A
SNLFGDILSD
LG
P
A
C
TG
T
IGIAPSANLN
P
E
RT
F
P
S
LFEP
V
HGSAPDI
Y
GKNIANPIA
T
I
WA
G
AMML
D
F
L
G
NG
D
E
R
FQQ
A
H
NG
I
LA
AIE
E
V
I
AH
G
PK
T
P
D
M-
K
---
G
N
A
--T
T
P
Q
V
A
DAI
C
K
II
fig|358709.5.peg.4376
Escherichia coli 101-1 (1-359/361)
M
M
K
T
MR
IA
A
IPGDGIG
K
EV
L
P
EG
IR
VL
Q
AA
A
ER
W
---
GFA
L
S
FEQMEW
A
SCE
Y
YSH
HG
K
M
--
M
P
DD
W
H
E
QLS
R
F
DA
IY
FG
A
VG
---
W
PDTV
PD
HI
S
LW
G
S
L
----
L
K
F
R
R
EFD
Q
Y
V
NLRPVRL
FP
G
V
P
--
CPL
-
A
G
K
Q
P
GDI
D
FYV
VRENTEG
E
Y
-
SSLG
GR
VN
E
G
T
E
H
E
V
VI
QES
VF
T
R
R
G
V
-----------------------
D
RI
L
R
Y
AFE
L
A
QS
R
P
R
KT
L
TS
AT
K
S
N
G
L
AI
S
MPY
W
D
E
R
V
EA
M
A
E
N
Y
--------------------
PEI
RWDKQH
ID
ILCA
R
F
V
MQ
P
E
R
FDV
V
V
A
SNLFGDILSD
LG
P
A
C
I
G
T
IGIAPSANLN
P
E
RT
F
P
S
LFEP
V
HGSAPDI
Y
GKNIANPIA
T
I
WA
G
AMML
D
F
L
G
NG
D
E
R
FQQ
A
H
NG
I
LA
AIE
E
V
I
AH
G
PK
T
P
D
M-
K
---
G
N
A
--T
T
P
Q
V
A
DAI
C
K
II
fig|413997.3.peg.1854
Escherichia coli B str. REL606 (1-359/361)
M
M
K
T
MR
IA
A
IPGDGIG
K
EV
L
P
EG
IR
VL
Q
AA
A
ER
W
---
GFA
L
S
FEQMEW
A
SCE
Y
YSH
HG
K
M
--
M
P
DD
W
H
E
QLS
R
F
DA
IY
FG
A
VG
---
W
PDTV
PD
HI
S
LW
G
S
L
----
L
K
F
R
R
EFD
Q
Y
V
NLRPVRL
FP
G
V
P
--
CPL
-
A
G
K
Q
P
GDI
D
FYV
VRENTEG
E
Y
-
SSLG
GR
VN
E
G
T
E
H
E
V
VI
QES
VF
T
R
R
G
V
-----------------------
D
RI
L
R
Y
AFE
L
A
QS
R
P
R
KT
L
TS
AT
K
S
N
G
L
AI
S
MPY
W
D
E
R
V
EA
M
A
E
N
Y
--------------------
PEI
RWDKQH
ID
ILCA
R
F
V
MQ
P
E
R
FDV
V
V
A
SNLFGDILSD
LG
P
A
C
I
G
T
IGIAPSANLN
P
E
RT
F
P
S
LFEP
V
HGSAPDI
Y
GKNIANPIA
T
I
WA
G
AMML
D
F
L
G
NG
D
E
R
FQQ
A
H
NG
I
LA
AIE
E
V
I
AH
G
PK
T
P
D
M-
K
---
G
N
A
--T
T
P
Q
V
A
DAI
C
K
II
fig|511693.5.peg.1883
Escherichia coli BL21 (1-359/361)
M
M
K
T
MR
IA
A
IPGDGIG
K
EV
L
P
EG
IR
VL
Q
AA
A
ER
W
---
GFA
L
S
FEQMEW
A
SCE
Y
YSH
HG
K
M
--
M
P
DD
W
H
E
QLS
R
F
DA
IY
FG
A
VG
---
W
PDTV
PD
HI
S
LW
G
S
L
----
L
K
F
R
R
EFD
Q
Y
V
NLRPVRL
FP
G
V
P
--
CPL
-
A
G
K
Q
P
GDI
D
FYV
VRENTEG
E
Y
-
SSLG
GR
VN
E
G
T
E
H
E
V
VI
QES
VF
T
R
R
G
V
-----------------------
D
RI
L
R
Y
AFE
L
A
QS
R
P
R
KT
L
TS
AT
K
S
N
G
L
AI
S
MPY
W
D
E
R
V
EA
M
A
E
N
Y
--------------------
PEI
RWDKQH
ID
ILCA
R
F
V
MQ
P
E
R
FDV
V
V
A
SNLFGDILSD
LG
P
A
C
I
G
T
IGIAPSANLN
P
E
RT
F
P
S
LFEP
V
HGSAPDI
Y
GKNIANPIA
T
I
WA
G
AMML
D
F
L
G
NG
D
E
R
FQQ
A
H
NG
I
LA
AIE
E
V
I
AH
G
PK
T
P
D
M-
K
---
G
N
A
--T
T
P
Q
V
A
DAI
C
K
II
fig|469008.4.peg.1896
Escherichia coli BL21(DE3) (1-359/361)
M
M
K
T
MR
IA
A
IPGDGIG
K
EV
L
P
EG
IR
VL
Q
AA
A
ER
W
---
GFA
L
S
FEQMEW
A
SCE
Y
YSH
HG
K
M
--
M
P
DD
W
H
E
QLS
R
F
DA
IY
FG
A
VG
---
W
PDTV
PD
HI
S
LW
G
S
L
----
L
K
F
R
R
EFD
Q
Y
V
NLRPVRL
FP
G
V
P
--
CPL
-
A
G
K
Q
P
GDI
D
FYV
VRENTEG
E
Y
-
SSLG
GR
VN
E
G
T
E
H
E
V
VI
QES
VF
T
R
R
G
V
-----------------------
D
RI
L
R
Y
AFE
L
A
QS
R
P
R
KT
L
TS
AT
K
S
N
G
L
AI
S
MPY
W
D
E
R
V
EA
M
A
E
N
Y
--------------------
PEI
RWDKQH
ID
ILCA
R
F
V
MQ
P
E
R
FDV
V
V
A
SNLFGDILSD
LG
P
A
C
I
G
T
IGIAPSANLN
P
E
RT
F
P
S
LFEP
V
HGSAPDI
Y
GKNIANPIA
T
I
WA
G
AMML
D
F
L
G
NG
D
E
R
FQQ
A
H
NG
I
LA
AIE
E
V
I
AH
G
PK
T
P
D
M-
K
---
G
N
A
--T
T
P
Q
V
A
DAI
C
K
II
fig|749547.3.peg.246
Escherichia coli MS 187-1 (1-359/361)
M
M
K
T
MR
IA
A
IPGDGIG
K
EV
L
P
EG
IR
VL
Q
AA
A
ER
W
---
GFA
L
S
FEQMEW
A
SCE
Y
YSH
HG
K
M
--
M
P
DD
W
H
E
QLS
R
F
DA
IY
FG
A
VG
---
W
PDTV
PD
HI
S
LW
G
S
L
----
L
K
F
R
R
EFD
Q
Y
V
NLRPVRL
FP
G
V
P
--
CPL
-
A
G
K
Q
P
GDI
D
FYV
VRENTEG
E
Y
-
SSLG
GR
VN
E
G
T
E
H
E
V
VI
QES
VF
T
R
R
G
V
-----------------------
D
RI
L
R
Y
AFE
L
A
QS
R
P
R
KT
L
TS
AT
K
S
N
G
L
AI
S
MPY
W
D
E
R
V
EA
M
A
E
N
Y
--------------------
PEI
RWDKQH
ID
ILCA
R
F
V
MQ
P
E
R
FDV
V
V
A
SNLFGDILSD
LG
P
A
C
I
G
T
IGIAPSANLN
P
E
RT
F
P
S
LFEP
V
HGSAPDI
Y
GKNIANPIA
T
I
WA
G
AMML
D
F
L
G
NG
D
E
R
FQQ
A
H
NG
I
LA
AIE
E
V
I
AH
G
PK
T
P
D
M-
K
---
G
N
A
--T
T
P
Q
V
A
DAI
C
K
II
fig|679204.3.peg.1326
Escherichia coli MS 145-7 (1-359/361)
M
M
K
T
MR
IA
A
IPGDGIG
K
EV
L
P
EG
IR
VL
Q
AA
A
ER
W
---
GFA
L
S
FEQMEW
A
SCE
Y
YSH
HG
K
M
--
M
P
DD
W
H
E
QLS
R
F
DA
IY
FG
A
VG
---
W
PDTV
PD
HI
S
LW
G
S
L
----
L
K
F
R
R
EFD
Q
Y
V
NLRPVRL
FP
G
V
P
--
CPL
-
A
G
K
Q
P
GDI
D
FYV
VRENTEG
E
Y
-
SSLG
C
R
VN
E
G
T
E
H
E
V
VI
QES
VF
T
R
R
G
V
-----------------------
D
RI
L
R
Y
AFE
L
A
QS
R
P
R
KT
L
TS
AT
K
S
N
G
L
AI
S
MPY
W
D
E
R
V
EA
M
A
E
N
Y
--------------------
PEI
RWDKQH
ID
ILCA
R
F
V
MQ
P
E
R
FDV
V
V
A
SNLFGDILSD
LG
P
A
C
TG
T
IGIAPSANLN
P
E
RT
F
P
S
LFEP
V
HGSAPDI
Y
GKNIANPIA
T
I
WA
G
AMML
D
F
L
G
NG
D
E
R
FQQ
A
H
NG
I
LA
AIE
E
V
I
AH
G
PK
T
P
D
M-
K
---
G
N
A
--T
T
P
Q
V
A
DAI
C
K
II
fig|656393.3.peg.2596
Escherichia coli H299 (1-359/361)
M
M
K
T
MR
IA
A
IPGDGIG
K
EV
L
P
EG
IR
VL
Q
AA
A
ER
W
---
GFA
L
S
FEQMEW
A
SCE
Y
YSH
HG
K
M
--
M
P
DD
W
H
E
QLS
R
F
DA
IY
FG
A
VG
---
W
PDTV
PD
HI
S
LW
G
S
L
----
L
K
F
R
R
EFD
Q
Y
V
NLRPVRL
FP
G
V
P
--
CPL
-
A
G
K
Q
P
GDI
D
FYV
VRENTEG
E
Y
-
SSLG
GR
VN
E
G
T
E
H
E
V
VI
QES
VF
T
R
R
G
V
-----------------------
D
RI
L
R
Y
AFE
L
A
QS
R
P
R
KT
L
TS
AT
K
S
N
G
L
AI
S
MPY
W
D
E
R
V
EA
M
A
E
N
Y
--------------------
PEI
RWDKQH
ID
ILCA
R
F
V
MQ
P
E
R
FDV
V
V
A
SNLFGDILSD
LG
P
A
C
TG
T
IGIAPSANLN
P
E
RT
F
P
S
LFEP
V
HGSAPDI
Y
GK
K
IANPIA
T
I
WA
G
AMML
D
F
L
G
NG
D
E
R
FQQ
A
H
NG
I
LA
AIE
E
V
I
AH
G
PK
T
P
D
M-
K
---
G
N
A
--T
T
P
Q
V
A
DAI
C
K
II
fig|637912.3.peg.908
Escherichia coli OP50 (1-359/361)
M
M
K
T
MR
IA
A
IPGDGIG
K
EV
L
P
EG
IR
VL
Q
AA
A
ER
W
---
GFA
L
S
FEQMEW
A
SCE
Y
YSH
HG
K
M
--
M
P
DD
W
H
E
QLS
R
F
DA
IY
FG
A
VG
---
W
PDTV
PD
HI
S
LW
G
S
L
----
L
K
F
R
R
EFD
Q
Y
V
NLRPVRL
FP
G
V
P
--
CPL
-
A
G
K
Q
P
GDI
D
FYV
VRENTEG
E
Y
-
SSLG
GR
VN
E
G
T
E
H
E
V
VI
QES
VF
T
R
R
G
V
-----------------------
D
RI
L
R
Y
AFE
L
A
QS
R
P
R
KT
L
TS
AT
K
S
N
G
L
AI
S
MPY
W
D
E
R
V
EA
M
A
E
N
Y
--------------------
PEI
RWDKQH
ID
ILCA
R
F
V
MQ
P
E
R
FDV
V
V
A
SNLFGDILSD
LG
P
A
C
I
G
T
IGIAPSANLN
P
E
RT
F
P
S
LFEP
V
HGSAPDI
Y
GKNIANPIA
T
I
WA
G
AMML
D
F
L
G
NG
D
E
R
FQQ
A
H
NG
I
LA
AIE
E
M
I
AH
G
PK
T
P
D
M-
K
---
G
N
A
--T
T
P
Q
V
A
DAI
C
K
II
fig|749537.3.peg.1380
Escherichia coli MS 115-1 (1-359/361)
M
M
K
T
MR
IA
A
IPGDGIG
K
EV
L
P
EG
IR
VL
Q
AA
A
ER
W
---
GFA
L
S
FEQMEW
A
SCE
Y
YSH
HG
K
M
--
M
P
DD
W
H
E
QLS
R
F
DA
IY
FG
A
VG
---
W
PDTV
PD
HI
S
LW
G
S
L
----
L
K
F
R
R
EFD
Q
Y
V
NLRPVRL
FP
G
V
P
--
CPL
-
A
G
K
Q
P
GDI
D
FYV
VRENTEG
E
Y
-
SSLG
GR
VN
E
G
T
E
H
E
V
VI
QES
VF
T
R
R
G
V
-----------------------
D
RI
L
R
Y
AFE
L
A
QS
R
P
R
KT
L
TS
AT
K
S
N
G
L
AI
S
MPY
W
D
E
R
V
EA
M
A
E
N
Y
--------------------
PEI
RWDKQH
ID
ILCA
R
F
V
MQ
T
E
R
FDV
V
V
A
SNLFGDILSD
LG
P
A
C
TG
T
IGIAPSANLN
P
E
RT
F
P
S
LFEP
V
HGSAPDI
Y
GKNIANPIA
T
I
WA
G
AMML
D
F
L
G
NG
D
E
R
FQQ
A
H
NG
I
LA
AIE
E
V
I
AH
G
PK
T
P
D
M-
K
---
G
N
A
--T
T
P
Q
V
A
DAI
C
K
II
fig|670897.3.peg.2078
Escherichia coli 2362-75 (25-414/416)
E
N
PI
I
P
Y
I
E
GDGIG
V
D
V
T
P
AM
LKV
V
DAA
V
E
K
A
YKG
ERK
IS
WMEIYT
G
EKS
-
TQV
Y
GQ
D
VW
LP
AE
T
L
D
LIR
E
Y
RV
AI
K
G
-
--
---
-
----
P
L
TT
P
VG
G
G
IRSLNV
A
LRQE
L
DLY
I
C
LRPVR
Y
YQG
T
P
--
S
P
V
-
-
-
K
H
P
ELT
D
MVI
F
REN
S
E
D
IY
-
AGIE
WK
AD
S
A
-
D
A
EKVI
N--
-
F
L
R
E
EM
GVKKIRFPEHCGIGIKPCSEEGT
KR
L
V
R
A
A
I
E
Y
A
IA
N
D
R
DS
VT
L
VH
K
G
N
I
M
KF
T
EGA
F
K
D
W
G
YQ
L
A
R
E
EFGGELIDGGPWLKVKNPNTGK
EI
VIKDVI
A
D
AFLQ
Q
I
L
LR
P
A
E
Y
DVI
A
C
M
NL
N
GD
YI
SD
AL
AA
Q
V
G
G
IGIAP
G
AN
IG
D
E
C-
-
-
A
LFE
A
T
HG
T
AP
KY
AG
QDKV
NP
GS
I
ILS
A
E
MMLRH
M
G
--
-
-
-
WTE
AA
DL
I
VK
GM
E
G
AI
NA
K
TV
T
Y
D
FE
R
LME
GA
K
LLK
C
S
E
F
GDAI
I
K
fig|216593.1.peg.1709
Escherichia coli E2348/69 (25-414/416)
E
N
PI
I
P
Y
I
E
GDGIG
V
D
V
T
P
AM
LKV
V
DAA
V
E
K
A
YKG
ERK
IS
WMEIYT
G
EKS
-
TQV
Y
GQ
D
VW
LP
AE
T
L
D
LIR
E
Y
RV
AI
K
G
-
--
---
-
----
P
L
TT
P
VG
G
G
IRSLNV
A
LRQE
L
DLY
I
C
LRPVR
Y
YQG
T
P
--
S
P
V
-
-
-
K
H
P
ELT
D
MVI
F
REN
S
E
D
IY
-
AGIE
WK
AD
S
A
-
D
A
EKVI
N--
-
F
L
R
E
EM
GVKKIRFPEHCGIGIKPCSEEGT
KR
L
V
R
A
A
I
E
Y
A
IA
N
D
R
DS
VT
L
VH
K
G
N
I
M
KF
T
EGA
F
K
D
W
G
YQ
L
A
R
E
EFGGELIDGGPWLKVKNPNTGK
EI
VIKDVI
A
D
AFLQ
Q
I
L
LR
P
A
E
Y
DVI
A
C
M
NL
N
GD
YI
SD
AL
AA
Q
V
G
G
IGIAP
G
AN
IG
D
E
C-
-
-
A
LFE
A
T
HG
T
AP
KY
AG
QDKV
NP
GS
I
ILS
A
E
MMLRH
M
G
--
-
-
-
WTE
AA
DL
I
VK
GM
E
G
AI
NA
K
TV
T
Y
D
FE
R
LME
GA
K
LLK
C
S
E
F
GDAI
I
K
fig|574521.7.peg.1310
Escherichia coli O127:H6 str. E2348/69 (25-414/416)
E
N
PI
I
P
Y
I
E
GDGIG
V
D
V
T
P
AM
LKV
V
DAA
V
E
K
A
YKG
ERK
IS
WMEIYT
G
EKS
-
TQV
Y
GQ
D
VW
LP
AE
T
L
D
LIR
E
Y
RV
AI
K
G
-
--
---
-
----
P
L
TT
P
VG
G
G
IRSLNV
A
LRQE
L
DLY
I
C
LRPVR
Y
YQG
T
P
--
S
P
V
-
-
-
K
H
P
ELT
D
MVI
F
REN
S
E
D
IY
-
AGIE
WK
AD
S
A
-
D
A
EKVI
N--
-
F
L
R
E
EM
GVKKIRFPEHCGIGIKPCSEEGT
KR
L
V
R
A
A
I
E
Y
A
IA
N
D
R
DS
VT
L
VH
K
G
N
I
M
KF
T
EGA
F
K
D
W
G
YQ
L
A
R
E
EFGGELIDGGPWLKVKNPNTGK
EI
VIKDVI
A
D
AFLQ
Q
I
L
LR
P
A
E
Y
DVI
A
C
M
NL
N
GD
YI
SD
AL
AA
Q
V
G
G
IGIAP
G
AN
IG
D
E
C-
-
-
A
LFE
A
T
HG
T
AP
KY
AG
QDKV
NP
GS
I
ILS
A
E
MMLRH
M
G
--
-
-
-
WTE
AA
DL
I
VK
GM
E
G
AI
NA
K
TV
T
Y
D
FE
R
LME
GA
K
LLK
C
S
E
F
GDAI
I
K
fig|550672.3.peg.1416
Escherichia coli B088 (25-414/416)
E
N
PI
I
P
Y
I
E
GDGIG
V
D
V
T
P
AM
LKV
V
DAA
V
E
K
A
YKG
ERK
IS
WMEIYT
G
EKS
-
TQV
Y
GQ
D
VW
LP
AE
T
L
D
LIR
E
Y
RV
AI
K
G
-
--
---
-
----
P
L
TT
P
VG
G
G
IRSLNV
A
LRQE
L
DLY
I
C
LRPVR
Y
YQG
T
P
--
S
P
V
-
-
-
K
H
P
ELT
D
MVI
F
REN
S
E
D
IY
-
AGIE
WK
AD
S
A
-
D
A
EKVI
K--
-
F
L
R
E
EM
GVKKIRFPEHCGIGIKPCSEEGT
KR
L
V
R
A
A
I
E
Y
A
IA
N
D
R
DS
VT
L
VH
K
G
N
I
M
KF
T
EGA
F
K
D
W
G
YQ
L
A
R
E
EFGGELIDGGPWLKVKNPNTGK
EI
VIKDVI
A
D
AFLQ
Q
I
L
LR
P
A
E
Y
DVI
A
C
M
NL
N
GD
YI
SD
AL
AA
Q
V
G
G
IGIAP
G
AN
IG
D
E
C-
-
-
A
LFE
A
T
HG
T
AP
KY
AG
QDKV
NP
GS
I
ILS
A
E
MMLRH
M
G
--
-
-
-
WTE
AA
NL
I
VK
GM
E
G
AI
NA
K
TV
T
Y
D
FE
R
LME
GA
K
LLK
C
S
E
F
GDAI
I
K
fig|562.371.peg.504
Escherichia coli 1044A (25-414/416)
E
N
PI
I
P
Y
I
E
GDGIG
V
D
V
T
P
AM
LKV
V
DAA
V
E
K
A
YKG
ERK
IS
WMEIYT
G
EKS
-
TQV
Y
GQ
D
VW
LP
AE
T
L
D
LIR
E
Y
RV
AI
K
G
-
--
---
-
----
P
L
TT
P
VG
G
G
IRSLNV
A
LRQE
L
DLY
I
C
LRPVR
Y
YQG
T
P
--
S
P
V
-
-
-
K
H
P
ELT
D
MVI
F
REN
S
E
D
IY
-
AGIE
WK
AD
S
A
-
D
A
EKVI
K--
-
F
L
R
E
EM
GVKKIRFPEHCGIGIKPCSEEGT
KR
L
V
R
A
A
I
E
Y
A
IA
N
D
R
DS
VT
L
VH
K
G
N
I
M
KF
T
EGA
F
K
D
W
G
YE
L
A
R
E
EFGGELIDGGPWLKVKNPNTGK
EI
VIKDVI
A
D
AFLQ
Q
I
L
LR
P
A
E
Y
DVI
A
C
M
NL
N
GD
YI
SD
AL
AA
Q
V
G
G
IGIAP
G
AN
IG
D
E
C-
-
-
A
LFE
A
T
HG
T
AP
KY
AG
QDKV
NP
GS
I
ILS
A
E
MMLRH
M
G
--
-
-
-
WTE
AA
DL
I
VK
GM
E
G
AI
NA
K
TV
T
Y
D
FE
R
LME
GA
K
LLK
C
S
E
F
GDAI
I
K
fig|562.373.peg.275
Escherichia coli 1125A (25-414/416)
E
N
PI
I
P
Y
I
E
GDGIG
V
D
V
T
P
AM
LKV
V
DAA
V
E
K
A
YKG
ERK
IS
WMEIYT
G
EKS
-
TQV
Y
GQ
D
VW
LP
AE
T
L
D
LIR
E
Y
RV
AI
K
G
-
--
---
-
----
P
L
TT
P
VG
G
G
IRSLNV
A
LRQE
L
DLY
I
C
LRPVR
Y
YQG
T
P
--
S
P
V
-
-
-
K
H
P
ELT
D
MVI
F
REN
S
E
D
IY
-
AGIE
WK
AD
S
A
-
D
A
EKVI
K--
-
F
L
R
E
EM
GVKKIRFPEHCGIGIKPCSEEGT
KR
L
V
R
A
A
I
E
Y
A
IA
N
D
R
DS
VT
L
VH
K
G
N
I
M
KF
T
EGA
F
K
D
W
G
YE
L
A
R
E
EFGGELIDGGPWLKVKNPNTGK
EI
VIKDVI
A
D
AFLQ
Q
I
L
LR
P
A
E
Y
DVI
A
C
M
NL
N
GD
YI
SD
AL
AA
Q
V
G
G
IGIAP
G
AN
IG
D
E
C-
-
-
A
LFE
A
T
HG
T
AP
KY
AG
QDKV
NP
GS
I
ILS
A
E
MMLRH
M
G
--
-
-
-
WTE
AA
DL
I
VK
GM
E
G
AI
NA
K
TV
T
Y
D
FE
R
LME
GA
K
LLK
C
S
E
F
GDAI
I
K
fig|562.372.peg.5332
Escherichia coli 1212A (25-414/416)
E
N
PI
I
P
Y
I
E
GDGIG
V
D
V
T
P
AM
LKV
V
DAA
V
E
K
A
YKG
ERK
IS
WMEIYT
G
EKS
-
TQV
Y
GQ
D
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T
L
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AI
K
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-
--
---
-
----
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L
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G
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IRSLNV
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L
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YQG
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--
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P
V
-
-
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K
H
P
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S
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WK
AD
S
A
-
D
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K--
-
F
L
R
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GVKKIRFPEHCGIGIKPCSEEGT
KR
L
V
R
A
A
I
E
Y
A
IA
N
D
R
DS
VT
L
VH
K
G
N
I
M
KF
T
EGA
F
K
D
W
G
YE
L
A
R
E
EFGGELIDGGPWLKVKNPNTGK
EI
VIKDVI
A
D
AFLQ
Q
I
L
LR
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A
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Y
DVI
A
C
M
NL
N
GD
YI
SD
AL
AA
Q
V
G
G
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AN
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D
E
C-
-
-
A
LFE
A
T
HG
T
AP
KY
AG
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NP
GS
I
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A
E
MMLRH
M
G
--
-
-
-
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AA
DL
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GM
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G
AI
NA
K
TV
T
Y
D
FE
R
LME
GA
K
LLK
C
S
E
F
GDAI
I
K
fig|562.374.peg.576
Escherichia coli 536A (25-414/416)
E
N
PI
I
P
Y
I
E
GDGIG
V
D
V
T
P
AM
LKV
V
DAA
V
E
K
A
YKG
ERK
IS
WMEIYT
G
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-
TQV
Y
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D
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LP
AE
T
L
D
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E
Y
RV
AI
K
G
-
--
---
-
----
P
L
TT
P
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G
G
IRSLNV
A
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L
DLY
I
C
LRPVR
Y
YQG
T
P
--
S
P
V
-
-
-
K
H
P
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D
MVI
F
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S
E
D
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-
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WK
AD
S
A
-
D
A
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K--
-
F
L
R
E
EM
GVKKIRFPEHCGIGIKPCSEEGT
KR
L
V
R
A
A
I
E
Y
A
IA
N
D
R
DS
VT
L
VH
K
G
N
I
M
KF
T
EGA
F
K
D
W
G
YE
L
A
R
E
EFGGELIDGGPWLKVKNPNTGK
EI
VIKDVI
A
D
AFLQ
Q
I
L
LR
P
A
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Y
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A
C
M
NL
N
GD
YI
SD
AL
AA
Q
V
G
G
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G
AN
IG
D
E
C-
-
-
A
LFE
A
T
HG
T
AP
KY
AG
QDKV
NP
GS
I
ILS
A
E
MMLRH
M
G
--
-
-
-
WTE
AA
DL
I
VK
GM
E
G
AI
NA
K
TV
T
Y
D
FE
R
LME
GA
K
LLK
C
S
E
F
GDAI
I
K
fig|83334.1.peg.1653
Escherichia coli O157:H7 (25-414/416)
E
N
PI
I
P
Y
I
E
GDGIG
V
D
V
T
P
AM
LKV
V
DAA
V
E
K
A
YKG
ERK
IS
WMEIYT
G
EKS
-
TQV
Y
GQ
D
VW
LP
AE
T
L
D
LIR
E
Y
RV
AI
K
G
-
--
---
-
----
P
L
TT
P
VG
G
G
IRSLNV
A
LRQE
L
DLY
I
C
LRPVR
Y
YQG
T
P
--
S
P
V
-
-
-
K
H
P
ELT
D
MVI
F
REN
S
E
D
IY
-
AGIE
WK
AD
S
A
-
D
A
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K--
-
F
L
R
E
EM
GVKKIRFPEHCGIGIKPCSEEGT
KR
L
V
R
A
A
I
E
Y
A
IA
N
D
R
DS
VT
L
VH
K
G
N
I
M
KF
T
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F
K
D
W
G
YE
L
A
R
E
EFGGELIDGGPWLKVKNPNTGK
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VIKDVI
A
D
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I
L
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A
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A
C
M
NL
N
GD
YI
SD
AL
AA
Q
V
G
G
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AN
IG
D
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C-
-
-
A
LFE
A
T
HG
T
AP
KY
AG
QDKV
NP
GS
I
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A
E
MMLRH
M
G
--
-
-
-
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AA
DL
I
VK
GM
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G
AI
NA
K
TV
T
Y
D
FE
R
LME
GA
K
LLK
C
S
E
F
GDAI
I
K
fig|155864.1.peg.1658
Escherichia coli O157:H7 EDL933 (25-414/416)
E
N
PI
I
P
Y
I
E
GDGIG
V
D
V
T
P
AM
LKV
V
DAA
V
E
K
A
YKG
ERK
IS
WMEIYT
G
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-
TQV
Y
GQ
D
VW
LP
AE
T
L
D
LIR
E
Y
RV
AI
K
G
-
--
---
-
----
P
L
TT
P
VG
G
G
IRSLNV
A
LRQE
L
DLY
I
C
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Y
YQG
T
P
--
S
P
V
-
-
-
K
H
P
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D
MVI
F
REN
S
E
D
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-
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WK
AD
S
A
-
D
A
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K--
-
F
L
R
E
EM
GVKKIRFPEHCGIGIKPCSEEGT
KR
L
V
R
A
A
I
E
Y
A
IA
N
D
R
DS
VT
L
VH
K
G
N
I
M
KF
T
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F
K
D
W
G
YE
L
A
R
E
EFGGELIDGGPWLKVKNPNTGK
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D
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Q
I
L
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A
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A
C
M
NL
N
GD
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SD
AL
AA
Q
V
G
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G
AN
IG
D
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C-
-
-
A
LFE
A
T
HG
T
AP
KY
AG
QDKV
NP
GS
I
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A
E
MMLRH
M
G
--
-
-
-
WTE
AA
DL
I
VK
GM
E
G
AI
NA
K
TV
T
Y
D
FE
R
LME
GA
K
LLK
C
S
E
F
GDAI
I
K
fig|155864.8.peg.1451
Escherichia coli O157:H7 EDL933 (25-414/416)
E
N
PI
I
P
Y
I
E
GDGIG
V
D
V
T
P
AM
LKV
V
DAA
V
E
K
A
YKG
ERK
IS
WMEIYT
G
EKS
-
TQV
Y
GQ
D
VW
LP
AE
T
L
D
LIR
E
Y
RV
AI
K
G
-
--
---
-
----
P
L
TT
P
VG
G
G
IRSLNV
A
LRQE
L
DLY
I
C
LRPVR
Y
YQG
T
P
--
S
P
V
-
-
-
K
H
P
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D
MVI
F
REN
S
E
D
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-
AGIE
WK
AD
S
A
-
D
A
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K--
-
F
L
R
E
EM
GVKKIRFPEHCGIGIKPCSEEGT
KR
L
V
R
A
A
I
E
Y
A
IA
N
D
R
DS
VT
L
VH
K
G
N
I
M
KF
T
EGA
F
K
D
W
G
YE
L
A
R
E
EFGGELIDGGPWLKVKNPNTGK
EI
VIKDVI
A
D
AFLQ
Q
I
L
LR
P
A
E
Y
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A
C
M
NL
N
GD
YI
SD
AL
AA
Q
V
G
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G
AN
IG
D
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C-
-
-
A
LFE
A
T
HG
T
AP
KY
AG
QDKV
NP
GS
I
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A
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MMLRH
M
G
--
-
-
-
WTE
AA
DL
I
VK
GM
E
G
AI
NA
K
TV
T
Y
D
FE
R
LME
GA
K
LLK
C
S
E
F
GDAI
I
K
fig|444454.5.peg.6084
Escherichia coli O157:H7 str. EC4024 (25-414/416)
E
N
PI
I
P
Y
I
E
GDGIG
V
D
V
T
P
AM
LKV
V
DAA
V
E
K
A
YKG
ERK
IS
WMEIYT
G
EKS
-
TQV
Y
GQ
D
VW
LP
AE
T
L
D
LIR
E
Y
RV
AI
K
G
-
--
---
-
----
P
L
TT
P
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G
G
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A
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L
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I
C
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Y
YQG
T
P
--
S
P
V
-
-
-
K
H
P
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D
MVI
F
REN
S
E
D
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-
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WK
AD
S
A
-
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K--
-
F
L
R
E
EM
GVKKIRFPEHCGIGIKPCSEEGT
KR
L
V
R
A
A
I
E
Y
A
IA
N
D
R
DS
VT
L
VH
K
G
N
I
M
KF
T
EGA
F
K
D
W
G
YE
L
A
R
E
EFGGELIDGGPWLKVKNPNTGK
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VIKDVI
A
D
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Q
I
L
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A
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Y
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A
C
M
NL
N
GD
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AL
AA
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V
G
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G
AN
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D
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C-
-
-
A
LFE
A
T
HG
T
AP
KY
AG
QDKV
NP
GS
I
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A
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MMLRH
M
G
--
-
-
-
WTE
AA
DL
I
VK
GM
E
G
AI
NA
K
TV
T
Y
D
FE
R
LME
GA
K
LLK
C
S
E
F
GDAI
I
K
fig|444449.5.peg.4941
Escherichia coli O157:H7 str. EC4042 (25-414/416)
E
N
PI
I
P
Y
I
E
GDGIG
V
D
V
T
P
AM
LKV
V
DAA
V
E
K
A
YKG
ERK
IS
WMEIYT
G
EKS
-
TQV
Y
GQ
D
VW
LP
AE
T
L
D
LIR
E
Y
RV
AI
K
G
-
--
---
-
----
P
L
TT
P
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G
G
IRSLNV
A
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L
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I
C
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Y
YQG
T
P
--
S
P
V
-
-
-
K
H
P
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D
MVI
F
REN
S
E
D
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-
AGIE
WK
AD
S
A
-
D
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K--
-
F
L
R
E
EM
GVKKIRFPEHCGIGIKPCSEEGT
KR
L
V
R
A
A
I
E
Y
A
IA
N
D
R
DS
VT
L
VH
K
G
N
I
M
KF
T
EGA
F
K
D
W
G
YE
L
A
R
E
EFGGELIDGGPWLKVKNPNTGK
EI
VIKDVI
A
D
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Q
I
L
LR
P
A
E
Y
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A
C
M
NL
N
GD
YI
SD
AL
AA
Q
V
G
G
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G
AN
IG
D
E
C-
-
-
A
LFE
A
T
HG
T
AP
KY
AG
QDKV
NP
GS
I
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A
E
MMLRH
M
G
--
-
-
-
WTE
AA
DL
I
VK
GM
E
G
AI
NA
K
TV
T
Y
D
FE
R
LME
GA
K
LLK
C
S
E
F
GDAI
I
K
fig|444448.5.peg.4205
Escherichia coli O157:H7 str. EC4045 (25-414/416)
E
N
PI
I
P
Y
I
E
GDGIG
V
D
V
T
P
AM
LKV
V
DAA
V
E
K
A
YKG
ERK
IS
WMEIYT
G
EKS
-
TQV
Y
GQ
D
VW
LP
AE
T
L
D
LIR
E
Y
RV
AI
K
G
-
--
---
-
----
P
L
TT
P
VG
G
G
IRSLNV
A
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L
DLY
I
C
LRPVR
Y
YQG
T
P
--
S
P
V
-
-
-
K
H
P
ELT
D
MVI
F
REN
S
E
D
IY
-
AGIE
WK
AD
S
A
-
D
A
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K--
-
F
L
R
E
EM
GVKKIRFPEHCGIGIKPCSEEGT
KR
L
V
R
A
A
I
E
Y
A
IA
N
D
R
DS
VT
L
VH
K
G
N
I
M
KF
T
EGA
F
K
D
W
G
YE
L
A
R
E
EFGGELIDGGPWLKVKNPNTGK
EI
VIKDVI
A
D
AFLQ
Q
I
L
LR
P
A
E
Y
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A
C
M
NL
N
GD
YI
SD
AL
AA
Q
V
G
G
IGIAP
G
AN
IG
D
E
C-
-
-
A
LFE
A
T
HG
T
AP
KY
AG
QDKV
NP
GS
I
ILS
A
E
MMLRH
M
G
--
-
-
-
WTE
AA
DL
I
VK
GM
E
G
AI
NA
K
TV
T
Y
D
FE
R
LME
GA
K
LLK
C
S
E
F
GDAI
I
K
fig|444453.5.peg.3819
Escherichia coli O157:H7 str. EC4076 (25-414/416)
E
N
PI
I
P
Y
I
E
GDGIG
V
D
V
T
P
AM
LKV
V
DAA
V
E
K
A
YKG
ERK
IS
WMEIYT
G
EKS
-
TQV
Y
GQ
D
VW
LP
AE
T
L
D
LIR
E
Y
RV
AI
K
G
-
--
---
-
----
P
L
TT
P
VG
G
G
IRSLNV
A
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L
DLY
I
C
LRPVR
Y
YQG
T
P
--
S
P
V
-
-
-
K
H
P
ELT
D
MVI
F
REN
S
E
D
IY
-
AGIE
WK
AD
S
A
-
D
A
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K--
-
F
L
R
E
EM
GVKKIRFPEHCGIGIKPCSEEGT
KR
L
V
R
A
A
I
E
Y
A
IA
N
D
R
DS
VT
L
VH
K
G
N
I
M
KF
T
EGA
F
K
D
W
G
YE
L
A
R
E
EFGGELIDGGPWLKVKNPNTGK
EI
VIKDVI
A
D
AFLQ
Q
I
L
LR
P
A
E
Y
DVI
A
C
M
NL
N
GD
YI
SD
AL
AA
Q
V
G
G
IGIAP
G
AN
IG
D
E
C-
-
-
A
LFE
A
T
HG
T
AP
KY
AG
QDKV
NP
GS
I
ILS
A
E
MMLRH
M
G
--
-
-
-
WTE
AA
DL
I
VK
GM
E
G
AI
NA
K
TV
T
Y
D
FE
R
LME
GA
K
LLK
C
S
E
F
GDAI
I
K
fig|444452.5.peg.2726
Escherichia coli O157:H7 str. EC4113 (25-414/416)
E
N
PI
I
P
Y
I
E
GDGIG
V
D
V
T
P
AM
LKV
V
DAA
V
E
K
A
YKG
ERK
IS
WMEIYT
G
EKS
-
TQV
Y
GQ
D
VW
LP
AE
T
L
D
LIR
E
Y
RV
AI
K
G
-
--
---
-
----
P
L
TT
P
VG
G
G
IRSLNV
A
LRQE
L
DLY
I
C
LRPVR
Y
YQG
T
P
--
S
P
V
-
-
-
K
H
P
ELT
D
MVI
F
REN
S
E
D
IY
-
AGIE
WK
AD
S
A
-
D
A
EKVI
K--
-
F
L
R
E
EM
GVKKIRFPEHCGIGIKPCSEEGT
KR
L
V
R
A
A
I
E
Y
A
IA
N
D
R
DS
VT
L
VH
K
G
N
I
M
KF
T
EGA
F
K
D
W
G
YE
L
A
R
E
EFGGELIDGGPWLKVKNPNTGK
EI
VIKDVI
A
D
AFLQ
Q
I
L
LR
P
A
E
Y
DVI
A
C
M
NL
N
GD
YI
SD
AL
AA
Q
V
G
G
IGIAP
G
AN
IG
D
E
C-
-
-
A
LFE
A
T
HG
T
AP
KY
AG
QDKV
NP
GS
I
ILS
A
E
MMLRH
M
G
--
-
-
-
WTE
AA
DL
I
VK
GM
E
G
AI
NA
K
TV
T
Y
D
FE
R
LME
GA
K
LLK
C
S
E
F
GDAI
I
K
fig|444450.8.peg.1665
Escherichia coli O157:H7 str. EC4115 (25-414/416)
E
N
PI
I
P
Y
I
E
GDGIG
V
D
V
T
P
AM
LKV
V
DAA
V
E
K
A
YKG
ERK
IS
WMEIYT
G
EKS
-
TQV
Y
GQ
D
VW
LP
AE
T
L
D
LIR
E
Y
RV
AI
K
G
-
--
---
-
----
P
L
TT
P
VG
G
G
IRSLNV
A
LRQE
L
DLY
I
C
LRPVR
Y
YQG
T
P
--
S
P
V
-
-
-
K
H
P
ELT
D
MVI
F
REN
S
E
D
IY
-
AGIE
WK
AD
S
A
-
D
A
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K--
-
F
L
R
E
EM
GVKKIRFPEHCGIGIKPCSEEGT
KR
L
V
R
A
A
I
E
Y
A
IA
N
D
R
DS
VT
L
VH
K
G
N
I
M
KF
T
EGA
F
K
D
W
G
YE
L
A
R
E
EFGGELIDGGPWLKVKNPNTGK
EI
VIKDVI
A
D
AFLQ
Q
I
L
LR
P
A
E
Y
DVI
A
C
M
NL
N
GD
YI
SD
AL
AA
Q
V
G
G
IGIAP
G
AN
IG
D
E
C-
-
-
A
LFE
A
T
HG
T
AP
KY
AG
QDKV
NP
GS
I
ILS
A
E
MMLRH
M
G
--
-
-
-
WTE
AA
DL
I
VK
GM
E
G
AI
NA
K
TV
T
Y
D
FE
R
LME
GA
K
LLK
C
S
E
F
GDAI
I
K
fig|444451.5.peg.3587
Escherichia coli O157:H7 str. EC4196 (25-414/416)
E
N
PI
I
P
Y
I
E
GDGIG
V
D
V
T
P
AM
LKV
V
DAA
V
E
K
A
YKG
ERK
IS
WMEIYT
G
EKS
-
TQV
Y
GQ
D
VW
LP
AE
T
L
D
LIR
E
Y
RV
AI
K
G
-
--
---
-
----
P
L
TT
P
VG
G
G
IRSLNV
A
LRQE
L
DLY
I
C
LRPVR
Y
YQG
T
P
--
S
P
V
-
-
-
K
H
P
ELT
D
MVI
F
REN
S
E
D
IY
-
AGIE
WK
AD
S
A
-
D
A
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K--
-
F
L
R
E
EM
GVKKIRFPEHCGIGIKPCSEEGT
KR
L
V
R
A
A
I
E
Y
A
IA
N
D
R
DS
VT
L
VH
K
G
N
I
M
KF
T
EGA
F
K
D
W
G
YE
L
A
R
E
EFGGELIDGGPWLKVKNPNTGK
EI
VIKDVI
A
D
AFLQ
Q
I
L
LR
P
A
E
Y
DVI
A
C
M
NL
N
GD
YI
SD
AL
AA
Q
V
G
G
IGIAP
G
AN
IG
D
E
C-
-
-
A
LFE
A
T
HG
T
AP
KY
AG
QDKV
NP
GS
I
ILS
A
E
MMLRH
M
G
--
-
-
-
WTE
AA
DL
I
VK
GM
E
G
AI
NA
K
TV
T
Y
D
FE
R
LME
GA
K
LLK
C
S
E
F
GDAI
I
K
fig|444447.5.peg.4443
Escherichia coli O157:H7 str. EC4206 (25-414/416)
E
N
PI
I
P
Y
I
E
GDGIG
V
D
V
T
P
AM
LKV
V
DAA
V
E
K
A
YKG
ERK
IS
WMEIYT
G
EKS
-
TQV
Y
GQ
D
VW
LP
AE
T
L
D
LIR
E
Y
RV
AI
K
G
-
--
---
-
----
P
L
TT
P
VG
G
G
IRSLNV
A
LRQE
L
DLY
I
C
LRPVR
Y
YQG
T
P
--
S
P
V
-
-
-
K
H
P
ELT
D
MVI
F
REN
S
E
D
IY
-
AGIE
WK
AD
S
A
-
D
A
EKVI
K--
-
F
L
R
E
EM
GVKKIRFPEHCGIGIKPCSEEGT
KR
L
V
R
A
A
I
E
Y
A
IA
N
D
R
DS
VT
L
VH
K
G
N
I
M
KF
T
EGA
F
K
D
W
G
YE
L
A
R
E
EFGGELIDGGPWLKVKNPNTGK
EI
VIKDVI
A
D
AFLQ
Q
I
L
LR
P
A
E
Y
DVI
A
C
M
NL
N
GD
YI
SD
AL
AA
Q
V
G
G
IGIAP
G
AN
IG
D
E
C-
-
-
A
LFE
A
T
HG
T
AP
KY
AG
QDKV
NP
GS
I
ILS
A
E
MMLRH
M
G
--
-
-
-
WTE
AA
DL
I
VK
GM
E
G
AI
NA
K
TV
T
Y
D
FE
R
LME
GA
K
LLK
C
S
E
F
GDAI
I
K
fig|478004.5.peg.3194
Escherichia coli O157:H7 str. EC4401 (25-414/416)
E
N
PI
I
P
Y
I
E
GDGIG
V
D
V
T
P
AM
LKV
V
DAA
V
E
K
A
YKG
ERK
IS
WMEIYT
G
EKS
-
TQV
Y
GQ
D
VW
LP
AE
T
L
D
LIR
E
Y
RV
AI
K
G
-
--
---
-
----
P
L
TT
P
VG
G
G
IRSLNV
A
LRQE
L
DLY
I
C
LRPVR
Y
YQG
T
P
--
S
P
V
-
-
-
K
H
P
ELT
D
MVI
F
REN
S
E
D
IY
-
AGIE
WK
AD
S
A
-
D
A
EKVI
K--
-
F
L
R
E
EM
GVKKIRFPEHCGIGIKPCSEEGT
KR
L
V
R
A
A
I
E
Y
A
IA
N
D
R
DS
VT
L
VH
K
G
N
I
M
KF
T
EGA
F
K
D
W
G
YE
L
A
R
E
EFGGELIDGGPWLKVKNPNTGK
EI
VIKDVI
A
D
AFLQ
Q
I
L
LR
P
A
E
Y
DVI
A
C
M
NL
N
GD
YI
SD
AL
AA
Q
V
G
G
IGIAP
G
AN
IG
D
E
C-
-
-
A
LFE
A
T
HG
T
AP
KY
AG
QDKV
NP
GS
I
ILS
A
E
MMLRH
M
G
--
-
-
-
WTE
AA
DL
I
VK
GM
E
G
AI
NA
K
TV
T
Y
D
FE
R
LME
GA
K
LLK
C
S
E
F
GDAI
I
K
fig|478005.5.peg.4680
Escherichia coli O157:H7 str. EC4486 (25-414/416)
E
N
PI
I
P
Y
I
E
GDGIG
V
D
V
T
P
AM
LKV
V
DAA
V
E
K
A
YKG
ERK
IS
WMEIYT
G
EKS
-
TQV
Y
GQ
D
VW
LP
AE
T
L
D
LIR
E
Y
RV
AI
K
G
-
--
---
-
----
P
L
TT
P
VG
G
G
IRSLNV
A
LRQE
L
DLY
I
C
LRPVR
Y
YQG
T
P
--
S
P
V
-
-
-
K
H
P
ELT
D
MVI
F
REN
S
E
D
IY
-
AGIE
WK
AD
S
A
-
D
A
EKVI
K--
-
F
L
R
E
EM
GVKKIRFPEHCGIGIKPCSEEGT
KR
L
V
R
A
A
I
E
Y
A
IA
N
D
R
DS
VT
L
VH
K
G
N
I
M
KF
T
EGA
F
K
D
W
G
YE
L
A
R
E
EFGGELIDGGPWLKVKNPNTGK
EI
VIKDVI
A
D
AFLQ
Q
I
L
LR
P
A
E
Y
DVI
A
C
M
NL
N
GD
YI
SD
AL
AA
Q
V
G
G
IGIAP
G
AN
IG
D
E
C-
-
-
A
LFE
A
T
HG
T
AP
KY
AG
QDKV
NP
GS
I
ILS
A
E
MMLRH
M
G
--
-
-
-
WTE
AA
DL
I
VK
GM
E
G
AI
NA
K
TV
T
Y
D
FE
R
LME
GA
K
LLK
C
S
E
F
GDAI
I
K
fig|478006.5.peg.2991
Escherichia coli O157:H7 str. EC4501 (25-414/416)
E
N
PI
I
P
Y
I
E
GDGIG
V
D
V
T
P
AM
LKV
V
DAA
V
E
K
A
YKG
ERK
IS
WMEIYT
G
EKS
-
TQV
Y
GQ
D
VW
LP
AE
T
L
D
LIR
E
Y
RV
AI
K
G
-
--
---
-
----
P
L
TT
P
VG
G
G
IRSLNV
A
LRQE
L
DLY
I
C
LRPVR
Y
YQG
T
P
--
S
P
V
-
-
-
K
H
P
ELT
D
MVI
F
REN
S
E
D
IY
-
AGIE
WK
AD
S
A
-
D
A
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K--
-
F
L
R
E
EM
GVKKIRFPEHCGIGIKPCSEEGT
KR
L
V
R
A
A
I
E
Y
A
IA
N
D
R
DS
VT
L
VH
K
G
N
I
M
KF
T
EGA
F
K
D
W
G
YE
L
A
R
E
EFGGELIDGGPWLKVKNPNTGK
EI
VIKDVI
A
D
AFLQ
Q
I
L
LR
P
A
E
Y
DVI
A
C
M
NL
N
GD
YI
SD
AL
AA
Q
V
G
G
IGIAP
G
AN
IG
D
E
C-
-
-
A
LFE
A
T
HG
T
AP
KY
AG
QDKV
NP
GS
I
ILS
A
E
MMLRH
M
G
--
-
-
-
WTE
AA
DL
I
VK
GM
E
G
AI
NA
K
TV
T
Y
D
FE
R
LME
GA
K
LLK
C
S
E
F
GDAI
I
K
fig|478007.5.peg.3132
Escherichia coli O157:H7 str. EC508 (25-414/416)
E
N
PI
I
P
Y
I
E
GDGIG
V
D
V
T
P
AM
LKV
V
DAA
V
E
K
A
YKG
ERK
IS
WMEIYT
G
EKS
-
TQV
Y
GQ
D
VW
LP
AE
T
L
D
LIR
E
Y
RV
AI
K
G
-
--
---
-
----
P
L
TT
P
VG
G
G
IRSLNV
A
LRQE
L
DLY
I
C
LRPVR
Y
YQG
T
P
--
S
P
V
-
-
-
K
H
P
ELT
D
MVI
F
REN
S
E
D
IY
-
AGIE
WK
AD
S
A
-
D
A
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K--
-
F
L
R
E
EM
GVKKIRFPEHCGIGIKPCSEEGT
KR
L
V
R
A
A
I
E
Y
A
IA
N
D
R
DS
VT
L
VH
K
G
N
I
M
KF
T
EGA
F
K
D
W
G
YE
L
A
R
E
EFGGELIDGGPWLKVKNPNTGK
EI
VIKDVI
A
D
AFLQ
Q
I
L
LR
P
A
E
Y
DVI
A
C
M
NL
N
GD
YI
SD
AL
AA
Q
V
G
G
IGIAP
G
AN
IG
D
E
C-
-
-
A
LFE
A
T
HG
T
AP
KY
AG
QDKV
NP
GS
I
ILS
A
E
MMLRH
M
G
--
-
-
-
WTE
AA
DL
I
VK
GM
E
G
AI
NA
K
TV
T
Y
D
FE
R
LME
GA
K
LLK
C
S
E
F
GDAI
I
K
fig|478008.5.peg.2832
Escherichia coli O157:H7 str. EC869 (25-414/416)
E
N
PI
I
P
Y
I
E
GDGIG
V
D
V
T
P
AM
LKV
V
DAA
V
E
K
A
YKG
ERK
IS
WMEIYT
G
EKS
-
TQV
Y
GQ
D
VW
LP
AE
T
L
D
LIR
E
Y
RV
AI
K
G
-
--
---
-
----
P
L
TT
P
VG
G
G
IRSLNV
A
LRQE
L
DLY
I
C
LRPVR
Y
YQG
T
P
--
S
P
V
-
-
-
K
H
P
ELT
D
MVI
F
REN
S
E
D
IY
-
AGIE
WK
AD
S
A
-
D
A
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K--
-
F
L
R
E
EM
GVKKIRFPEHCGIGIKPCSEEGT
KR
L
V
R
A
A
I
E
Y
A
IA
N
D
R
DS
VT
L
VH
K
G
N
I
M
KF
T
EGA
F
K
D
W
G
YE
L
A
R
E
EFGGELIDGGPWLKVKNPNTGK
EI
VIKDVI
A
D
AFLQ
Q
I
L
LR
P
A
E
Y
DVI
A
C
M
NL
N
GD
YI
SD
AL
AA
Q
V
G
G
IGIAP
G
AN
IG
D
E
C-
-
-
A
LFE
A
T
HG
T
AP
KY
AG
QDKV
NP
GS
I
ILS
A
E
MMLRH
M
G
--
-
-
-
WTE
AA
DL
I
VK
GM
E
G
AI
NA
K
TV
T
Y
D
FE
R
LME
GA
K
LLK
C
S
E
F
GDAI
I
K
fig|637388.3.peg.4324
Escherichia coli O157:H7 str. FRIK2000 (25-414/416)
E
N
PI
I
P
Y
I
E
GDGIG
V
D
V
T
P
AM
LKV
V
DAA
V
E
K
A
YKG
ERK
IS
WMEIYT
G
EKS
-
TQV
Y
GQ
D
VW
LP
AE
T
L
D
LIR
E
Y
RV
AI
K
G
-
--
---
-
----
P
L
TT
P
VG
G
G
IRSLNV
A
LRQE
L
DLY
I
C
LRPVR
Y
YQG
T
P
--
S
P
V
-
-
-
K
H
P
ELT
D
MVI
F
REN
S
E
D
IY
-
AGIE
WK
AD
S
A
-
D
A
EKVI
K--
-
F
L
R
E
EM
GVKKIRFPEHCGIGIKPCSEEGT
KR
L
V
R
A
A
I
E
Y
A
IA
N
D
R
DS
VT
L
VH
K
G
N
I
M
KF
T
EGA
F
K
D
W
G
YE
L
A
R
E
EFGGELIDGGPWLKVKNPNTGK
EI
VIKDVI
A
D
AFLQ
Q
I
L
LR
P
A
E
Y
DVI
A
C
M
NL
N
GD
YI
SD
AL
AA
Q
V
G
G
IGIAP
G
AN
IG
D
E
C-
-
-
A
LFE
A
T
HG
T
AP
KY
AG
QDKV
NP
GS
I
ILS
A
E
MMLRH
M
G
--
-
-
-
WTE
AA
DL
I
VK
GM
E
G
AI
NA
K
TV
T
Y
D
FE
R
LME
GA
K
LLK
C
S
E
F
GDAI
I
K
fig|570506.3.peg.4621
Escherichia coli O157:H7 str. FRIK966 (25-414/416)
E
N
PI
I
P
Y
I
E
GDGIG
V
D
V
T
P
AM
LKV
V
DAA
V
E
K
A
YKG
ERK
IS
WMEIYT
G
EKS
-
TQV
Y
GQ
D
VW
LP
AE
T
L
D
LIR
E
Y
RV
AI
K
G
-
--
---
-
----
P
L
TT
P
VG
G
G
IRSLNV
A
LRQE
L
DLY
I
C
LRPVR
Y
YQG
T
P
--
S
P
V
-
-
-
K
H
P
ELT
D
MVI
F
REN
S
E
D
IY
-
AGIE
WK
AD
S
A
-
D
A
EKVI
K--
-
F
L
R
E
EM
GVKKIRFPEHCGIGIKPCSEEGT
KR
L
V
R
A
A
I
E
Y
A
IA
N
D
R
DS
VT
L
VH
K
G
N
I
M
KF
T
EGA
F
K
D
W
G
YE
L
A
R
E
EFGGELIDGGPWLKVKNPNTGK
EI
VIKDVI
A
D
AFLQ
Q
I
L
LR
P
A
E
Y
DVI
A
C
M
NL
N
GD
YI
SD
AL
AA
Q
V
G
G
IGIAP
G
AN
IG
D
E
C-
-
-
A
LFE
A
T
HG
T
AP
KY
AG
QDKV
NP
GS
I
ILS
A
E
MMLRH
M
G
--
-
-
-
WTE
AA
DL
I
VK
GM
E
G
AI
NA
K
TV
T
Y
D
FE
R
LME
GA
K
LLK
C
S
E
F
GDAI
I
K
fig|386585.9.peg.1708
Escherichia coli O157:H7 str. Sakai (25-414/416)
E
N
PI
I
P
Y
I
E
GDGIG
V
D
V
T
P
AM
LKV
V
DAA
V
E
K
A
YKG
ERK
IS
WMEIYT
G
EKS
-
TQV
Y
GQ
D
VW
LP
AE
T
L
D
LIR
E
Y
RV
AI
K
G
-
--
---
-
----
P
L
TT
P
VG
G
G
IRSLNV
A
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L
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L
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fig|544404.4.peg.1528
Escherichia coli O157:H7 str. TW14359 (25-414/416)
E
N
PI
I
P
Y
I
E
GDGIG
V
D
V
T
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fig|502346.5.peg.2685
Escherichia coli O157:H7 str. TW14588 (25-414/416)
E
N
PI
I
P
Y
I
E
GDGIG
V
D
V
T
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K
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S
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fig|701177.3.peg.1406
Escherichia coli O55:H7 str. CB9615 (25-414/416)
E
N
PI
I
P
Y
I
E
GDGIG
V
D
V
T
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fig|1040638.4.peg.4465
Escherichia coli O104:H4 str. LB226692 (25-414/416)
E
N
PI
I
P
Y
I
E
GDGIG
V
D
V
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fig|6666666.5357.peg.1699
Escherichia coli TY-2482 (25-414/416)
E
N
PI
I
P
Y
I
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GDGIG
V
D
V
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fig|216592.1.peg.1561
Escherichia coli 042 (25-414/416)
E
N
PI
I
P
Y
I
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GDGIG
V
D
V
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fig|216592.3.peg.1253
Escherichia coli 042 (25-414/416)
E
N
PI
I
P
Y
I
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GDGIG
V
D
V
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fig|358709.5.peg.1482
Escherichia coli 101-1 (25-414/416)
E
N
PI
I
P
Y
I
E
GDGIG
V
D
V
T
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R
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K
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fig|670888.3.peg.1764
Escherichia coli 1827-70 (25-414/416)
E
N
PI
I
P
Y
I
E
GDGIG
V
D
V
T
P
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L
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R
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fig|362663.8.peg.1152
Escherichia coli 536 (25-414/416)
E
N
PI
I
P
Y
I
E
GDGIG
V
D
V
T
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KR
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R
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VT
L
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K
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FE
R
LME
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fig|362663.9.peg.1152
Escherichia coli 536 (25-414/416)
E
N
PI
I
P
Y
I
E
GDGIG
V
D
V
T
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V
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-
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KR
L
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R
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VT
L
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K
G
N
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D
FE
R
LME
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K
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C
S
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I
K
fig|585055.6.peg.1281
Escherichia coli 55989 (25-414/416)
E
N
PI
I
P
Y
I
E
GDGIG
V
D
V
T
P
AM
LKV
V
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---
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----
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L
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L
R
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GVKKIRFPEHCGIGIKPCSEEG
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KR
L
V
R
A
A
I
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IA
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VT
L
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N
I
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T
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K
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S
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fig|585055.8.peg.1280
Escherichia coli 55989 (25-414/416)
E
N
PI
I
P
Y
I
E
GDGIG
V
D
V
T
P
AM
LKV
V
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A
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L
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K
G
-
--
---
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----
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L
TT
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-
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L
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K
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fig|525281.3.peg.339
Escherichia coli 83972 (25-414/416)
E
N
PI
I
P
Y
I
E
GDGIG
V
D
V
T
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AM
LKV
V
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GVKKIRFPEHCGIGIKPCSEEGT
KR
L
V
R
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I
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R
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VT
L
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K
G
N
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R
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fig|655817.3.peg.1425
Escherichia coli ABU 83972 (25-414/416)
E
N
PI
I
P
Y
I
E
GDGIG
V
D
V
T
P
AM
LKV
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V
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A
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L
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N
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fig|405955.13.peg.1140
Escherichia coli APEC O1 (25-414/416)
E
N
PI
I
P
Y
I
E
GDGIG
V
D
V
T
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AM
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K
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L
V
R
A
A
I
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D
R
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VT
L
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K
G
N
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R
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K
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C
S
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fig|405955.9.peg.962
Escherichia coli APEC O1 (25-414/416)
E
N
PI
I
P
Y
I
E
GDGIG
V
D
V
T
P
AM
LKV
V
DAA
V
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A
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L
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K
G
-
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----
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L
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S
A
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L
R
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GVKKIRFPEHCGIGIKPCSEEGT
KR
L
V
R
A
A
I
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N
D
R
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VT
L
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K
G
N
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M
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T
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D
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A
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NL
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--
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Y
D
FE
R
LME
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K
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C
S
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fig|413997.3.peg.1195
Escherichia coli B str. REL606 (25-414/416)
E
N
PI
I
P
Y
I
E
GDGIG
V
D
V
T
P
AM
LKV
V
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L
V
R
A
A
I
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IA
N
D
R
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VT
L
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K
G
N
I
M
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T
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D
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L
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A
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NL
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A
T
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--
-
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Y
D
FE
R
LME
GA
K
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C
S
E
F
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I
K
fig|344601.3.peg.3874
Escherichia coli B171 (25-414/416)
E
N
PI
I
P
Y
I
E
GDGIG
V
D
V
T
P
AM
LKV
V
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V
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T
L
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AI
K
G
-
--
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----
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L
TT
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G
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L
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Y
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P
--
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-
-
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K
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D
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F
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S
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D
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WK
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S
A
-
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K--
-
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L
R
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EM
GVKKIRFPEHCGIGIKPCSEEGT
KR
L
V
R
A
A
I
E
Y
A
IA
N
D
R
DS
VT
L
VH
K
G
N
I
M
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T
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F
K
D
W
G
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L
A
R
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EFGGELIDGGPWLKVKNPNTGK
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A
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I
L
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A
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Y
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A
C
M
NL
N
GD
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AL
AA
Q
V
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AN
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D
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C-
-
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A
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A
T
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T
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--
-
-
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AA
DL
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TV
T
Y
D
FE
R
LME
GA
K
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C
S
E
F
GDAI
I
K
fig|344601.5.peg.4060
Escherichia coli B171 (25-414/416)
E
N
PI
I
P
Y
I
E
GDGIG
V
D
V
T
P
AM
LKV
V
DAA
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D
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LP
AE
T
L
D
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E
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K
G
-
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----
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L
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L
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Y
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--
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-
-
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K
H
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D
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F
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D
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S
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GVKKIRFPEHCGIGIKPCSEEGT
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L
V
R
A
A
I
E
Y
A
IA
N
D
R
DS
VT
L
VH
K
G
N
I
M
KF
T
EGA
F
K
D
W
G
YQ
L
A
R
E
EFGGELIDGGPWLKVKNPNTGK
EI
VIKDVI
A
D
AFLQ
Q
I
L
LR
P
A
E
Y
DVI
A
C
M
NL
N
GD
YI
SD
AL
AA
Q
V
G
G
IGIAP
G
AN
IG
D
E
C-
-
-
A
LFE
A
T
HG
T
AP
KY
AG
QDKV
NP
GS
I
ILS
A
E
MMLRH
M
G
--
-
-
-
WTE
AA
DL
I
VK
GM
E
G
AI
NA
K
TV
T
Y
D
FE
R
LME
GA
K
LLK
C
S
E
F
GDAI
I
K
fig|550676.3.peg.633
Escherichia coli B185 (25-414/416)
E
N
PI
I
P
Y
I
E
GDGIG
V
D
V
T
P
AM
LKV
V
DAA
V
E
K
A
YKG
ERK
IS
WMEIYT
G
EKS
-
TQV
Y
GQ
D
VW
LP
AE
T
L
D
LIR
E
Y
RV
AI
K
G
-
--
---
-
----
P
L
TT
P
VG
G
G
IRSLNV
A
LRQE
L
DLY
I
C
LRPVR
Y
YQG
T
P
--
S
P
V
-
-
-
K
H
P
ELT
D
MVI
F
REN
S
E
D
IY
-
AGIE
WK
AD
S
A
-
D
A
EKVI
K--
-
F
L
R
E
EM
GVKKIRFPEHCGIGIKPCSEEGT
KR
L
V
R
A
A
I
E
Y
A
IA
N
D
R
DS
VT
L
VH
K
G
N
I
M
KF
T
EGA
F
K
D
W
G
YQ
L
A
R
E
EFGGELIDGGPWLKVKNPNTGK
EI
VIKDVI
A
D
AFLQ
Q
I
L
LR
P
A
E
Y
DVI
A
C
M
NL
N
GD
YI
SD
AL
AA
Q
V
G
G
IGIAP
G
AN
IG
D
E
C-
-
-
A
LFE
A
T
HG
T
AP
KY
AG
QDKV
NP
GS
I
ILS
A
E
MMLRH
M
G
--
-
-
-
WTE
AA
DL
I
VK
GM
E
G
AI
NA
K
TV
T
Y
D
FE
R
LME
GA
K
LLK
C
S
E
F
GDAI
I
K
fig|550677.3.peg.2581
Escherichia coli B354 (25-414/416)
E
N
PI
I
P
Y
I
E
GDGIG
V
D
V
T
P
AM
LKV
V
DAA
V
E
K
A
YKG
ERK
IS
WMEIYT
G
EKS
-
TQV
Y
GQ
D
VW
LP
AE
T
L
D
LIR
E
Y
RV
AI
K
G
-
--
---
-
----
P
L
TT
P
VG
G
G
IRSLNV
A
LRQE
L
DLY
I
C
LRPVR
Y
YQG
T
P
--
S
P
V
-
-
-
K
H
P
ELT
D
MVI
F
REN
S
E
D
IY
-
AGIE
WK
AD
S
A
-
D
A
EKVI
K--
-
F
L
R
E
EM
GVKKIRFPEHCGIGIKPCSEEGT
KR
L
V
R
A
A
I
E
Y
A
IA
N
D
R
DS
VT
L
VH
K
G
N
I
M
KF
T
EGA
F
K
D
W
G
YQ
L
A
R
E
EFGGELIDGGPWLKVKNPNTGK
EI
VIKDVI
A
D
AFLQ
Q
I
L
LR
P
A
E
Y
DVI
A
C
M
NL
N
GD
YI
SD
AL
AA
Q
V
G
G
IGIAP
G
AN
IG
D
E
C-
-
-
A
LFE
A
T
HG
T
AP
KY
AG
QDKV
NP
GS
I
ILS
A
E
MMLRH
M
G
--
-
-
-
WTE
AA
DL
I
VK
GM
E
G
AI
NA
K
TV
T
Y
D
FE
R
LME
GA
K
LLK
C
S
E
F
GDAI
I
K
fig|340184.3.peg.3418
Escherichia coli B7A (25-414/416)
E
N
PI
I
P
Y
I
E
GDGIG
V
D
V
T
P
AM
LKV
V
DAA
V
E
K
A
YKG
ERK
IS
WMEIYT
G
EKS
-
TQV
Y
GQ
D
VW
LP
AE
T
L
D
LIR
E
Y
RV
AI
K
G
-
--
---
-
----
P
L
TT
P
VG
G
G
IRSLNV
A
LRQE
L
DLY
I
C
LRPVR
Y
YQG
T
P
--
S
P
V
-
-
-
K
H
P
ELT
D
MVI
F
REN
S
E
D
IY
-
AGIE
WK
AD
S
A
-
D
A
EKVI
K--
-
F
L
R
E
EM
GVKKIRFPEHCGIGIKPCSEEGT
KR
L
V
R
A
A
I
E
Y
A
IA
N
D
R
DS
VT
L
VH
K
G
N
I
M
KF
T
EGA
F
K
D
W
G
YQ
L
A
R
E
EFGGELIDGGPWLKVKNPNTGK
EI
VIKDVI
A
D
AFLQ
Q
I
L
LR
P
A
E
Y
DVI
A
C
M
NL
N
GD
YI
SD
AL
AA
Q
V
G
G
IGIAP
G
AN
IG
D
E
C-
-
-
A
LFE
A
T
HG
T
AP
KY
AG
QDKV
NP
GS
I
ILS
A
E
MMLRH
M
G
--
-
-
-
WTE
AA
DL
I
VK
GM
E
G
AI
NA
K
TV
T
Y
D
FE
R
LME
GA
K
LLK
C
S
E
F
GDAI
I
K
fig|340184.6.peg.3569
Escherichia coli B7A (25-414/416)
E
N
PI
I
P
Y
I
E
GDGIG
V
D
V
T
P
AM
LKV
V
DAA
V
E
K
A
YKG
ERK
IS
WMEIYT
G
EKS
-
TQV
Y
GQ
D
VW
LP
AE
T
L
D
LIR
E
Y
RV
AI
K
G
-
--
---
-
----
P
L
TT
P
VG
G
G
IRSLNV
A
LRQE
L
DLY
I
C
LRPVR
Y
YQG
T
P
--
S
P
V
-
-
-
K
H
P
ELT
D
MVI
F
REN
S
E
D
IY
-
AGIE
WK
AD
S
A
-
D
A
EKVI
K--
-
F
L
R
E
EM
GVKKIRFPEHCGIGIKPCSEEGT
KR
L
V
R
A
A
I
E
Y
A
IA
N
D
R
DS
VT
L
VH
K
G
N
I
M
KF
T
EGA
F
K
D
W
G
YQ
L
A
R
E
EFGGELIDGGPWLKVKNPNTGK
EI
VIKDVI
A
D
AFLQ
Q
I
L
LR
P
A
E
Y
DVI
A
C
M
NL
N
GD
YI
SD
AL
AA
Q
V
G
G
IGIAP
G
AN
IG
D
E
C-
-
-
A
LFE
A
T
HG
T
AP
KY
AG
QDKV
NP
GS
I
ILS
A
E
MMLRH
M
G
--
-
-
-
WTE
AA
DL
I
VK
GM
E
G
AI
NA
K
TV
T
Y
D
FE
R
LME
GA
K
LLK
C
S
E
F
GDAI
I
K
fig|511693.5.peg.1225
Escherichia coli BL21 (25-414/416)
E
N
PI
I
P
Y
I
E
GDGIG
V
D
V
T
P
AM
LKV
V
DAA
V
E
K
A
YKG
ERK
IS
WMEIYT
G
EKS
-
TQV
Y
GQ
D
VW
LP
AE
T
L
D
LIR
E
Y
RV
AI
K
G
-
--
---
-
----
P
L
TT
P
VG
G
G
IRSLNV
A
LRQE
L
DLY
I
C
LRPVR
Y
YQG
T
P
--
S
P
V
-
-
-
K
H
P
ELT
D
MVI
F
REN
S
E
D
IY
-
AGIE
WK
AD
S
A
-
D
A
EKVI
K--
-
F
L
R
E
EM
GVKKIRFPEHCGIGIKPCSEEGT
KR
L
V
R
A
A
I
E
Y
A
IA
N
D
R
DS
VT
L
VH
K
G
N
I
M
KF
T
EGA
F
K
D
W
G
YQ
L
A
R
E
EFGGELIDGGPWLKVKNPNTGK
EI
VIKDVI
A
D
AFLQ
Q
I
L
LR
P
A
E
Y
DVI
A
C
M
NL
N
GD
YI
SD
AL
AA
Q
V
G
G
IGIAP
G
AN
IG
D
E
C-
-
-
A
LFE
A
T
HG
T
AP
KY
AG
QDKV
NP
GS
I
ILS
A
E
MMLRH
M
G
--
-
-
-
WTE
AA
DL
I
VK
GM
E
G
AI
NA
K
TV
T
Y
D
FE
R
LME
GA
K
LLK
C
S
E
F
GDAI
I
K
fig|469008.4.peg.2540
Escherichia coli BL21(DE3) (25-414/416)
E
N
PI
I
P
Y
I
E
GDGIG
V
D
V
T
P
AM
LKV
V
DAA
V
E
K
A
YKG
ERK
IS
WMEIYT
G
EKS
-
TQV
Y
GQ
D
VW
LP
AE
T
L
D
LIR
E
Y
RV
AI
K
G
-
--
---
-
----
P
L
TT
P
VG
G
G
IRSLNV
A
LRQE
L
DLY
I
C
LRPVR
Y
YQG
T
P
--
S
P
V
-
-
-
K
H
P
ELT
D
MVI
F
REN
S
E
D
IY
-
AGIE
WK
AD
S
A
-
D
A
EKVI
K--
-
F
L
R
E
EM
GVKKIRFPEHCGIGIKPCSEEGT
KR
L
V
R
A
A
I
E
Y
A
IA
N
D
R
DS
VT
L
VH
K
G
N
I
M
KF
T
EGA
F
K
D
W
G
YQ
L
A
R
E
EFGGELIDGGPWLKVKNPNTGK
EI
VIKDVI
A
D
AFLQ
Q
I
L
LR
P
A
E
Y
DVI
A
C
M
NL
N
GD
YI
SD
AL
AA
Q
V
G
G
IGIAP
G
AN
IG
D
E
C-
-
-
A
LFE
A
T
HG
T
AP
KY
AG
QDKV
NP
GS
I
ILS
A
E
MMLRH
M
G
--
-
-
-
WTE
AA
DL
I
VK
GM
E
G
AI
NA
K
TV
T
Y
D
FE
R
LME
GA
K
LLK
C
S
E
F
GDAI
I
K
fig|199310.1.peg.1469
Escherichia coli CFT073 (25-414/416)
E
N
PI
I
P
Y
I
E
GDGIG
V
D
V
T
P
AM
LKV
V
DAA
V
E
K
A
YKG
ERK
IS
WMEIYT
G
EKS
-
TQV
Y
GQ
D
VW
LP
AE
T
L
D
LIR
E
Y
RV
AI
K
G
-
--
---
-
----
P
L
TT
P
VG
G
G
IRSLNV
A
LRQE
L
DLY
I
C
LRPVR
Y
YQG
T
P
--
S
P
V
-
-
-
K
H
P
ELT
D
MVI
F
REN
S
E
D
IY
-
AGIE
WK
AD
S
A
-
D
A
EKVI
K--
-
F
L
R
E
EM
GVKKIRFPEHCGIGIKPCSEEGT
KR
L
V
R
A
A
I
E
Y
A
IA
N
D
R
DS
VT
L
VH
K
G
N
I
M
KF
T
EGA
F
K
D
W
G
YQ
L
A
R
E
EFGGELIDGGPWLKVKNPNTGK
EI
VIKDVI
A
D
AFLQ
Q
I
L
LR
P
A
E
Y
DVI
A
C
M
NL
N
GD
YI
SD
AL
AA
Q
V
G
G
IGIAP
G
AN
IG
D
E
C-
-
-
A
LFE
A
T
HG
T
AP
KY
AG
QDKV
NP
GS
I
ILS
A
E
MMLRH
M
G
--
-
-
-
WTE
AA
DL
I
VK
GM
E
G
AI
NA
K
TV
T
Y
D
FE
R
LME
GA
K
LLK
C
S
E
F
GDAI
I
K
fig|199310.4.peg.1417
Escherichia coli CFT073 (25-414/416)
E
N
PI
I
P
Y
I
E
GDGIG
V
D
V
T
P
AM
LKV
V
DAA
V
E
K
A
YKG
ERK
IS
WMEIYT
G
EKS
-
TQV
Y
GQ
D
VW
LP
AE
T
L
D
LIR
E
Y
RV
AI
K
G
-
--
---
-
----
P
L
TT
P
VG
G
G
IRSLNV
A
LRQE
L
DLY
I
C
LRPVR
Y
YQG
T
P
--
S
P
V
-
-
-
K
H
P
ELT
D
MVI
F
REN
S
E
D
IY
-
AGIE
WK
AD
S
A
-
D
A
EKVI
K--
-
F
L
R
E
EM
GVKKIRFPEHCGIGIKPCSEEGT
KR
L
V
R
A
A
I
E
Y
A
IA
N
D
R
DS
VT
L
VH
K
G
N
I
M
KF
T
EGA
F
K
D
W
G
YQ
L
A
R
E
EFGGELIDGGPWLKVKNPNTGK
EI
VIKDVI
A
D
AFLQ
Q
I
L
LR
P
A
E
Y
DVI
A
C
M
NL
N
GD
YI
SD
AL
AA
Q
V
G
G
IGIAP
G
AN
IG
D
E
C-
-
-
A
LFE
A
T
HG
T
AP
KY
AG
QDKV
NP
GS
I
ILS
A
E
MMLRH
M
G
--
-
-
-
WTE
AA
DL
I
VK
GM
E
G
AI
NA
K
TV
T
Y
D
FE
R
LME
GA
K
LLK
C
S
E
F
GDAI
I
K
fig|340186.3.peg.4958
Escherichia coli E110019 (25-414/416)
E
N
PI
I
P
Y
I
E
GDGIG
V
D
V
T
P
AM
LKV
V
DAA
V
E
K
A
YKG
ERK
IS
WMEIYT
G
EKS
-
TQV
Y
GQ
D
VW
LP
AE
T
L
D
LIR
E
Y
RV
AI
K
G
-
--
---
-
----
P
L
TT
P
VG
G
G
IRSLNV
A
LRQE
L
DLY
I
C
LRPVR
Y
YQG
T
P
--
S
P
V
-
-
-
K
H
P
ELT
D
MVI
F
REN
S
E
D
IY
-
AGIE
WK
AD
S
A
-
D
A
EKVI
K--
-
F
L
R
E
EM
GVKKIRFPEHCGIGIKPCSEEGT
KR
L
V
R
A
A
I
E
Y
A
IA
N
D
R
DS
VT
L
VH
K
G
N
I
M
KF
T
EGA
F
K
D
W
G
YQ
L
A
R
E
EFGGELIDGGPWLKVKNPNTGK
EI
VIKDVI
A
D
AFLQ
Q
I
L
LR
P
A
E
Y
DVI
A
C
M
NL
N
GD
YI
SD
AL
AA
Q
V
G
G
IGIAP
G
AN
IG
D
E
C-
-
-
A
LFE
A
T
HG
T
AP
KY
AG
QDKV
NP
GS
I
ILS
A
E
MMLRH
M
G
--
-
-
-
WTE
AA
DL
I
VK
GM
E
G
AI
NA
K
TV
T
Y
D
FE
R
LME
GA
K
LLK
C
S
E
F
GDAI
I
K
fig|340186.5.peg.5219
Escherichia coli E110019 (25-414/416)
E
N
PI
I
P
Y
I
E
GDGIG
V
D
V
T
P
AM
LKV
V
DAA
V
E
K
A
YKG
ERK
IS
WMEIYT
G
EKS
-
TQV
Y
GQ
D
VW
LP
AE
T
L
D
LIR
E
Y
RV
AI
K
G
-
--
---
-
----
P
L
TT
P
VG
G
G
IRSLNV
A
LRQE
L
DLY
I
C
LRPVR
Y
YQG
T
P
--
S
P
V
-
-
-
K
H
P
ELT
D
MVI
F
REN
S
E
D
IY
-
AGIE
WK
AD
S
A
-
D
A
EKVI
K--
-
F
L
R
E
EM
GVKKIRFPEHCGIGIKPCSEEGT
KR
L
V
R
A
A
I
E
Y
A
IA
N
D
R
DS
VT
L
VH
K
G
N
I
M
KF
T
EGA
F
K
D
W
G
YQ
L
A
R
E
EFGGELIDGGPWLKVKNPNTGK
EI
VIKDVI
A
D
AFLQ
Q
I
L
LR
P
A
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DVI
A
C
M
NL
N
GD
YI
SD
AL
AA
Q
V
G
G
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AN
IG
D
E
C-
-
-
A
LFE
A
T
HG
T
AP
KY
AG
QDKV
NP
GS
I
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A
E
MMLRH
M
G
--
-
-
-
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AA
DL
I
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GM
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G
AI
NA
K
TV
T
Y
D
FE
R
LME
GA
K
LLK
C
S
E
F
GDAI
I
K
fig|340185.3.peg.4626
Escherichia coli E22 (25-414/416)
E
N
PI
I
P
Y
I
E
GDGIG
V
D
V
T
P
AM
LKV
V
DAA
V
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A
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ERK
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WMEIYT
G
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-
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D
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T
L
D
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AI
K
G
-
--
---
-
----
P
L
TT
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G
G
IRSLNV
A
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L
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I
C
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Y
YQG
T
P
--
S
P
V
-
-
-
K
H
P
ELT
D
MVI
F
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S
E
D
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-
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WK
AD
S
A
-
D
A
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K--
-
F
L
R
E
EM
GVKKIRFPEHCGIGIKPCSEEGT
KR
L
V
R
A
A
I
E
Y
A
IA
N
D
R
DS
VT
L
VH
K
G
N
I
M
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T
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F
K
D
W
G
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L
A
R
E
EFGGELIDGGPWLKVKNPNTGK
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VIKDVI
A
D
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I
L
LR
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A
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A
C
M
NL
N
GD
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AA
Q
V
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IG
D
E
C-
-
-
A
LFE
A
T
HG
T
AP
KY
AG
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NP
GS
I
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A
E
MMLRH
M
G
--
-
-
-
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AA
DL
I
VK
GM
E
G
AI
NA
K
TV
T
Y
D
FE
R
LME
GA
K
LLK
C
S
E
F
GDAI
I
K
fig|340185.4.peg.4880
Escherichia coli E22 (25-414/416)
E
N
PI
I
P
Y
I
E
GDGIG
V
D
V
T
P
AM
LKV
V
DAA
V
E
K
A
YKG
ERK
IS
WMEIYT
G
EKS
-
TQV
Y
GQ
D
VW
LP
AE
T
L
D
LIR
E
Y
RV
AI
K
G
-
--
---
-
----
P
L
TT
P
VG
G
G
IRSLNV
A
LRQE
L
DLY
I
C
LRPVR
Y
YQG
T
P
--
S
P
V
-
-
-
K
H
P
ELT
D
MVI
F
REN
S
E
D
IY
-
AGIE
WK
AD
S
A
-
D
A
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K--
-
F
L
R
E
EM
GVKKIRFPEHCGIGIKPCSEEGT
KR
L
V
R
A
A
I
E
Y
A
IA
N
D
R
DS
VT
L
VH
K
G
N
I
M
KF
T
EGA
F
K
D
W
G
YQ
L
A
R
E
EFGGELIDGGPWLKVKNPNTGK
EI
VIKDVI
A
D
AFLQ
Q
I
L
LR
P
A
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Y
DVI
A
C
M
NL
N
GD
YI
SD
AL
AA
Q
V
G
G
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G
AN
IG
D
E
C-
-
-
A
LFE
A
T
HG
T
AP
KY
AG
QDKV
NP
GS
I
ILS
A
E
MMLRH
M
G
--
-
-
-
WTE
AA
DL
I
VK
GM
E
G
AI
NA
K
TV
T
Y
D
FE
R
LME
GA
K
LLK
C
S
E
F
GDAI
I
K
fig|331111.12.peg.1591
Escherichia coli E24377A (25-414/416)
E
N
PI
I
P
Y
I
E
GDGIG
V
D
V
T
P
AM
LKV
V
DAA
V
E
K
A
YKG
ERK
IS
WMEIYT
G
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-
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Y
GQ
D
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LP
AE
T
L
D
LIR
E
Y
RV
AI
K
G
-
--
---
-
----
P
L
TT
P
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G
G
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L
DLY
I
C
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Y
YQG
T
P
--
S
P
V
-
-
-
K
H
P
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D
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F
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S
E
D
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WK
AD
S
A
-
D
A
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K--
-
F
L
R
E
EM
GVKKIRFPEHCGIGIKPCSEEGT
KR
L
V
R
A
A
I
E
Y
A
IA
N
D
R
DS
VT
L
VH
K
G
N
I
M
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T
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F
K
D
W
G
YQ
L
A
R
E
EFGGELIDGGPWLKVKNPNTGK
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VIKDVI
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D
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Q
I
L
LR
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A
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A
C
M
NL
N
GD
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AL
AA
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V
G
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D
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C-
-
-
A
LFE
A
T
HG
T
AP
KY
AG
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NP
GS
I
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A
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MMLRH
M
G
--
-
-
-
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AA
DL
I
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GM
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G
AI
NA
K
TV
T
Y
D
FE
R
LME
GA
K
LLK
C
S
E
F
GDAI
I
K
fig|331111.3.peg.3767
Escherichia coli E24377A (25-414/416)
E
N
PI
I
P
Y
I
E
GDGIG
V
D
V
T
P
AM
LKV
V
DAA
V
E
K
A
YKG
ERK
IS
WMEIYT
G
EKS
-
TQV
Y
GQ
D
VW
LP
AE
T
L
D
LIR
E
Y
RV
AI
K
G
-
--
---
-
----
P
L
TT
P
VG
G
G
IRSLNV
A
LRQE
L
DLY
I
C
LRPVR
Y
YQG
T
P
--
S
P
V
-
-
-
K
H
P
ELT
D
MVI
F
REN
S
E
D
IY
-
AGIE
WK
AD
S
A
-
D
A
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K--
-
F
L
R
E
EM
GVKKIRFPEHCGIGIKPCSEEGT
KR
L
V
R
A
A
I
E
Y
A
IA
N
D
R
DS
VT
L
VH
K
G
N
I
M
KF
T
EGA
F
K
D
W
G
YQ
L
A
R
E
EFGGELIDGGPWLKVKNPNTGK
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VIKDVI
A
D
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Q
I
L
LR
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A
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Y
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A
C
M
NL
N
GD
YI
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AL
AA
Q
V
G
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D
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C-
-
-
A
LFE
A
T
HG
T
AP
KY
AG
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NP
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A
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--
-
-
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AA
DL
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K
TV
T
Y
D
FE
R
LME
GA
K
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C
S
E
F
GDAI
I
K
fig|562.375.peg.5088
Escherichia coli EC4100B (25-414/416)
E
N
PI
I
P
Y
I
E
GDGIG
V
D
V
T
P
AM
LKV
V
DAA
V
E
K
A
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ERK
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-
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D
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AE
T
L
D
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Y
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AI
K
G
-
--
---
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----
P
L
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G
G
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L
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--
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-
-
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S
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D
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WK
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S
A
-
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-
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L
R
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EM
GVKKIRFPEHCGIGIKPCSEEGT
KR
L
V
R
A
A
I
E
Y
A
IA
N
D
R
DS
VT
L
VH
K
G
N
I
M
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T
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F
K
D
W
G
YQ
L
A
R
E
EFGGELIDGGPWLKVKNPNTGK
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I
L
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A
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Y
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A
C
M
NL
N
GD
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AA
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C-
-
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T
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AP
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NP
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A
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--
-
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AA
DL
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K
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T
Y
D
FE
R
LME
GA
K
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C
S
E
F
GDAI
I
K
fig|585397.7.peg.1291
Escherichia coli ED1a (25-414/416)
E
N
PI
I
P
Y
I
E
GDGIG
V
D
V
T
P
AM
LKV
V
DAA
V
E
K
A
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ERK
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WMEIYT
G
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-
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D
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LP
AE
T
L
D
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E
Y
RV
AI
K
G
-
--
---
-
----
P
L
TT
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G
G
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L
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C
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Y
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T
P
--
S
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V
-
-
-
K
H
P
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D
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F
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S
E
D
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WK
AD
S
A
-
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-
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L
R
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EM
GVKKIRFPEHCGIGIKPCSEEGT
KR
L
V
R
A
A
I
E
Y
A
IA
N
D
R
DS
VT
L
VH
K
G
N
I
M
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T
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F
K
D
W
G
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L
A
R
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EFGGELIDGGPWLKVKNPNTGK
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A
D
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I
L
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A
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A
C
M
NL
N
GD
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AA
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V
G
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C-
-
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A
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A
T
HG
T
AP
KY
AG
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NP
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I
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A
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M
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--
-
-
-
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AA
DL
I
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GM
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G
AI
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K
TV
T
Y
D
FE
R
LME
GA
K
LLK
C
S
E
F
GDAI
I
K
fig|585397.9.peg.1287
Escherichia coli ED1a (25-414/416)
E
N
PI
I
P
Y
I
E
GDGIG
V
D
V
T
P
AM
LKV
V
DAA
V
E
K
A
YKG
ERK
IS
WMEIYT
G
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-
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Y
GQ
D
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LP
AE
T
L
D
LIR
E
Y
RV
AI
K
G
-
--
---
-
----
P
L
TT
P
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G
G
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L
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I
C
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Y
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T
P
--
S
P
V
-
-
-
K
H
P
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D
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F
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S
E
D
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WK
AD
S
A
-
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K--
-
F
L
R
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EM
GVKKIRFPEHCGIGIKPCSEEGT
KR
L
V
R
A
A
I
E
Y
A
IA
N
D
R
DS
VT
L
VH
K
G
N
I
M
KF
T
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F
K
D
W
G
YQ
L
A
R
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EFGGELIDGGPWLKVKNPNTGK
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VIKDVI
A
D
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Q
I
L
LR
P
A
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Y
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A
C
M
NL
N
GD
YI
SD
AL
AA
Q
V
G
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AN
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D
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C-
-
-
A
LFE
A
T
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T
AP
KY
AG
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NP
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I
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A
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M
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--
-
-
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AA
DL
I
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GM
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G
AI
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K
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T
Y
D
FE
R
LME
GA
K
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C
S
E
F
GDAI
I
K
fig|340197.3.peg.3201
Escherichia coli F11 (25-414/416)
E
N
PI
I
P
Y
I
E
GDGIG
V
D
V
T
P
AM
LKV
V
DAA
V
E
K
A
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ERK
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WMEIYT
G
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-
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Y
GQ
D
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LP
AE
T
L
D
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E
Y
RV
AI
K
G
-
--
---
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----
P
L
TT
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G
G
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L
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C
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Y
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T
P
--
S
P
V
-
-
-
K
H
P
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D
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F
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S
E
D
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WK
AD
S
A
-
D
A
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K--
-
F
L
R
E
EM
GVKKIRFPEHCGIGIKPCSEEGT
KR
L
V
R
A
A
I
E
Y
A
IA
N
D
R
DS
VT
L
VH
K
G
N
I
M
KF
T
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F
K
D
W
G
YQ
L
A
R
E
EFGGELIDGGPWLKVKNPNTGK
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VIKDVI
A
D
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Q
I
L
LR
P
A
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Y
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A
C
M
NL
N
GD
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AL
AA
Q
V
G
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AN
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D
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C-
-
-
A
LFE
A
T
HG
T
AP
KY
AG
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NP
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I
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A
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MMLRH
M
G
--
-
-
-
WTE
AA
DL
I
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GM
E
G
AI
NA
K
TV
T
Y
D
FE
R
LME
GA
K
LLK
C
S
E
F
GDAI
I
K
fig|340197.5.peg.3346
Escherichia coli F11 (25-414/416)
E
N
PI
I
P
Y
I
E
GDGIG
V
D
V
T
P
AM
LKV
V
DAA
V
E
K
A
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ERK
IS
WMEIYT
G
EKS
-
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Y
GQ
D
VW
LP
AE
T
L
D
LIR
E
Y
RV
AI
K
G
-
--
---
-
----
P
L
TT
P
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G
G
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A
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L
DLY
I
C
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Y
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T
P
--
S
P
V
-
-
-
K
H
P
ELT
D
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F
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S
E
D
IY
-
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WK
AD
S
A
-
D
A
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K--
-
F
L
R
E
EM
GVKKIRFPEHCGIGIKPCSEEGT
KR
L
V
R
A
A
I
E
Y
A
IA
N
D
R
DS
VT
L
VH
K
G
N
I
M
KF
T
EGA
F
K
D
W
G
YQ
L
A
R
E
EFGGELIDGGPWLKVKNPNTGK
EI
VIKDVI
A
D
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Q
I
L
LR
P
A
E
Y
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A
C
M
NL
N
GD
YI
SD
AL
AA
Q
V
G
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AN
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D
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C-
-
-
A
LFE
A
T
HG
T
AP
KY
AG
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NP
GS
I
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A
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M
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--
-
-
-
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AA
DL
I
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GM
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G
AI
NA
K
TV
T
Y
D
FE
R
LME
GA
K
LLK
C
S
E
F
GDAI
I
K
fig|656379.3.peg.1308
Escherichia coli FVEC1302 (25-414/416)
E
N
PI
I
P
Y
I
E
GDGIG
V
D
V
T
P
AM
LKV
V
DAA
V
E
K
A
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IS
WMEIYT
G
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Y
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D
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LP
AE
T
L
D
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E
Y
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AI
K
G
-
--
---
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----
P
L
TT
P
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G
G
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A
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L
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Y
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T
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--
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V
-
-
-
K
H
P
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D
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F
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S
E
D
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WK
AD
S
A
-
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K--
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F
L
R
E
EM
GVKKIRFPEHCGIGIKPCSEEGT
KR
L
V
R
A
A
I
E
Y
A
IA
N
D
R
DS
VT
L
VH
K
G
N
I
M
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T
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F
K
D
W
G
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L
A
R
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EFGGELIDGGPWLKVKNPNTGK
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VIKDVI
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I
L
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A
C
M
NL
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G
G
IGIAP
G
AN
IG
D
E
C-
-
-
A
LFE
A
T
HG
T
AP
KY
AG
QDKV
NP
GS
I
ILS
A
E
MMLRH
M
G
--
-
-
-
WTE
AA
DL
I
VK
GM
E
G
AI
NA
K
TV
T
Y
D
FE
R
LME
GA
K
LLK
C
S
E
F
GDAI
I
K
fig|656380.3.peg.1883
Escherichia coli FVEC1412 (25-414/416)
E
N
PI
I
P
Y
I
E
GDGIG
V
D
V
T
P
AM
LKV
V
DAA
V
E
K
A
YKG
ERK
IS
WMEIYT
G
EKS
-
TQV
Y
GQ
D
VW
LP
AE
T
L
D
LIR
E
Y
RV
AI
K
G
-
--
---
-
----
P
L
TT
P
VG
G
G
IRSLNV
A
LRQE
L
DLY
I
C
LRPVR
Y
YQG
T
P
--
S
P
V
-
-
-
K
H
P
ELT
D
MVI
F
REN
S
E
D
IY
-
AGIE
WK
AD
S
A
-
D
A
EKVI
K--
-
F
L
R
E
EM
GVKKIRFPEHCGIGIKPCSEEGT
KR
L
V
R
A
A
I
E
Y
A
IA
N
D
R
DS
VT
L
VH
K
G
N
I
M
KF
T
EGA
F
K
D
W
G
YQ
L
A
R
E
EFGGELIDGGPWLKVKNPNTGK
EI
VIKDVI
A
D
AFLQ
Q
I
L
LR
P
A
E
Y
DVI
A
C
M
NL
N
GD
YI
SD
AL
AA
Q
V
G
G
IGIAP
G
AN
IG
D
E
C-
-
-
A
LFE
A
T
HG
T
AP
KY
AG
QDKV
NP
GS
I
ILS
A
E
MMLRH
M
G
--
-
-
-
WTE
AA
DL
I
VK
GM
E
G
AI
NA
K
TV
T
Y
D
FE
R
LME
GA
K
LLK
C
S
E
F
GDAI
I
K
fig|656393.3.peg.1912
Escherichia coli H299 (25-414/416)
E
N
PI
I
P
Y
I
E
GDGIG
V
D
V
T
P
AM
LKV
V
DAA
V
E
K
A
YKG
ERK
IS
WMEIYT
G
EKS
-
TQV
Y
GQ
D
VW
LP
AE
T
L
D
LIR
E
Y
RV
AI
K
G
-
--
---
-
----
P
L
TT
P
VG
G
G
IRSLNV
A
LRQE
L
DLY
I
C
LRPVR
Y
YQG
T
P
--
S
P
V
-
-
-
K
H
P
ELT
D
MVI
F
REN
S
E
D
IY
-
AGIE
WK
AD
S
A
-
D
A
EKVI
K--
-
F
L
R
E
EM
GVKKIRFPEHCGIGIKPCSEEGT
KR
L
V
R
A
A
I
E
Y
A
IA
N
D
R
DS
VT
L
VH
K
G
N
I
M
KF
T
EGA
F
K
D
W
G
YQ
L
A
R
E
EFGGELIDGGPWLKVKNPNTGK
EI
VIKDVI
A
D
AFLQ
Q
I
L
LR
P
A
E
Y
DVI
A
C
M
NL
N
GD
YI
SD
AL
AA
Q
V
G
G
IGIAP
G
AN
IG
D
E
C-
-
-
A
LFE
A
T
HG
T
AP
KY
AG
QDKV
NP
GS
I
ILS
A
E
MMLRH
M
G
--
-
-
-
WTE
AA
DL
I
VK
GM
E
G
AI
NA
K
TV
T
Y
D
FE
R
LME
GA
K
LLK
C
S
E
F
GDAI
I
K
fig|656408.3.peg.1219
Escherichia coli H591 (25-414/416)
E
N
PI
I
P
Y
I
E
GDGIG
V
D
V
T
P
AM
LKV
V
DAA
V
E
K
A
YKG
ERK
IS
WMEIYT
G
EKS
-
TQV
Y
GQ
D
VW
LP
AE
T
L
D
LIR
E
Y
RV
AI
K
G
-
--
---
-
----
P
L
TT
P
VG
G
G
IRSLNV
A
LRQE
L
DLY
I
C
LRPVR
Y
YQG
T
P
--
S
P
V
-
-
-
K
H
P
ELT
D
MVI
F
REN
S
E
D
IY
-
AGIE
WK
AD
S
A
-
D
A
EKVI
K--
-
F
L
R
E
EM
GVKKIRFPEHCGIGIKPCSEEGT
KR
L
V
R
A
A
I
E
Y
A
IA
N
D
R
DS
VT
L
VH
K
G
N
I
M
KF
T
EGA
F
K
D
W
G
YQ
L
A
R
E
EFGGELIDGGPWLKVKNPNTGK
EI
VIKDVI
A
D
AFLQ
Q
I
L
LR
P
A
E
Y
DVI
A
C
M
NL
N
GD
YI
SD
AL
AA
Q
V
G
G
IGIAP
G
AN
IG
D
E
C-
-
-
A
LFE
A
T
HG
T
AP
KY
AG
QDKV
NP
GS
I
ILS
A
E
MMLRH
M
G
--
-
-
-
WTE
AA
DL
I
VK
GM
E
G
AI
NA
K
TV
T
Y
D
FE
R
LME
GA
K
LLK
C
S
E
F
GDAI
I
K
fig|585034.4.peg.1167
Escherichia coli IAI1 (25-414/416)
E
N
PI
I
P
Y
I
E
GDGIG
V
D
V
T
P
AM
LKV
V
DAA
V
E
K
A
YKG
ERK
IS
WMEIYT
G
EKS
-
TQV
Y
GQ
D
VW
LP
AE
T
L
D
LIR
E
Y
RV
AI
K
G
-
--
---
-
----
P
L
TT
P
VG
G
G
IRSLNV
A
LRQE
L
DLY
I
C
LRPVR
Y
YQG
T
P
--
S
P
V
-
-
-
K
H
P
ELT
D
MVI
F
REN
S
E
D
IY
-
AGIE
WK
AD
S
A
-
D
A
EKVI
K--
-
F
L
R
E
EM
GVKKIRFPEHCGIGIKPCSEEGT
KR
L
V
R
A
A
I
E
Y
A
IA
N
D
R
DS
VT
L
VH
K
G
N
I
M
KF
T
EGA
F
K
D
W
G
YQ
L
A
R
E
EFGGELIDGGPWLKVKNPNTGK
EI
VIKDVI
A
D
AFLQ
Q
I
L
LR
P
A
E
Y
DVI
A
C
M
NL
N
GD
YI
SD
AL
AA
Q
V
G
G
IGIAP
G
AN
IG
D
E
C-
-
-
A
LFE
A
T
HG
T
AP
KY
AG
QDKV
NP
GS
I
ILS
A
E
MMLRH
M
G
--
-
-
-
WTE
AA
DL
I
VK
GM
E
G
AI
NA
K
TV
T
Y
D
FE
R
LME
GA
K
LLK
C
S
E
F
GDAI
I
K
fig|585034.5.peg.1164
Escherichia coli IAI1 (25-414/416)
E
N
PI
I
P
Y
I
E
GDGIG
V
D
V
T
P
AM
LKV
V
DAA
V
E
K
A
YKG
ERK
IS
WMEIYT
G
EKS
-
TQV
Y
GQ
D
VW
LP
AE
T
L
D
LIR
E
Y
RV
AI
K
G
-
--
---
-
----
P
L
TT
P
VG
G
G
IRSLNV
A
LRQE
L
DLY
I
C
LRPVR
Y
YQG
T
P
--
S
P
V
-
-
-
K
H
P
ELT
D
MVI
F
REN
S
E
D
IY
-
AGIE
WK
AD
S
A
-
D
A
EKVI
K--
-
F
L
R
E
EM
GVKKIRFPEHCGIGIKPCSEEGT
KR
L
V
R
A
A
I
E
Y
A
IA
N
D
R
DS
VT
L
VH
K
G
N
I
M
KF
T
EGA
F
K
D
W
G
YQ
L
A
R
E
EFGGELIDGGPWLKVKNPNTGK
EI
VIKDVI
A
D
AFLQ
Q
I
L
LR
P
A
E
Y
DVI
A
C
M
NL
N
GD
YI
SD
AL
AA
Q
V
G
G
IGIAP
G
AN
IG
D
E
C-
-
-
A
LFE
A
T
HG
T
AP
KY
AG
QDKV
NP
GS
I
ILS
A
E
MMLRH
M
G
--
-
-
-
WTE
AA
DL
I
VK
GM
E
G
AI
NA
K
TV
T
Y
D
FE
R
LME
GA
K
LLK
C
S
E
F
GDAI
I
K
fig|585057.4.peg.2075
Escherichia coli IAI39 (25-414/416)
E
N
PI
I
P
Y
I
E
GDGIG
V
D
V
T
P
AM
LKV
V
DAA
V
E
K
A
YKG
ERK
IS
WMEIYT
G
EKS
-
TQV
Y
GQ
D
VW
LP
AE
T
L
D
LIR
E
Y
RV
AI
K
G
-
--
---
-
----
P
L
TT
P
VG
G
G
IRSLNV
A
LRQE
L
DLY
I
C
LRPVR
Y
YQG
T
P
--
S
P
V
-
-
-
K
H
P
ELT
D
MVI
F
REN
S
E
D
IY
-
AGIE
WK
AD
S
A
-
D
A
EKVI
K--
-
F
L
R
E
EM
GVKKIRFPEHCGIGIKPCSEEGT
KR
L
V
R
A
A
I
E
Y
A
IA
N
D
R
DS
VT
L
VH
K
G
N
I
M
KF
T
EGA
F
K
D
W
G
YQ
L
A
R
E
EFGGELIDGGPWLKVKNPNTGK
EI
VIKDVI
A
D
AFLQ
Q
I
L
LR
P
A
E
Y
DVI
A
C
M
NL
N
GD
YI
SD
AL
AA
Q
V
G
G
IGIAP
G
AN
IG
D
E
C-
-
-
A
LFE
A
T
HG
T
AP
KY
AG
QDKV
NP
GS
I
ILS
A
E
MMLRH
M
G
--
-
-
-
WTE
AA
DL
I
VK
GM
E
G
AI
NA
K
TV
T
Y
D
FE
R
LME
GA
K
LLK
C
S
E
F
GDAI
I
K
fig|585057.6.peg.2074
Escherichia coli IAI39 (25-414/416)
E
N
PI
I
P
Y
I
E
GDGIG
V
D
V
T
P
AM
LKV
V
DAA
V
E
K
A
YKG
ERK
IS
WMEIYT
G
EKS
-
TQV
Y
GQ
D
VW
LP
AE
T
L
D
LIR
E
Y
RV
AI
K
G
-
--
---
-
----
P
L
TT
P
VG
G
G
IRSLNV
A
LRQE
L
DLY
I
C
LRPVR
Y
YQG
T
P
--
S
P
V
-
-
-
K
H
P
ELT
D
MVI
F
REN
S
E
D
IY
-
AGIE
WK
AD
S
A
-
D
A
EKVI
K--
-
F
L
R
E
EM
GVKKIRFPEHCGIGIKPCSEEGT
KR
L
V
R
A
A
I
E
Y
A
IA
N
D
R
DS
VT
L
VH
K
G
N
I
M
KF
T
EGA
F
K
D
W
G
YQ
L
A
R
E
EFGGELIDGGPWLKVKNPNTGK
EI
VIKDVI
A
D
AFLQ
Q
I
L
LR
P
A
E
Y
DVI
A
C
M
NL
N
GD
YI
SD
AL
AA
Q
V
G
G
IGIAP
G
AN
IG
D
E
C-
-
-
A
LFE
A
T
HG
T
AP
KY
AG
QDKV
NP
GS
I
ILS
A
E
MMLRH
M
G
--
-
-
-
WTE
AA
DL
I
VK
GM
E
G
AI
NA
K
TV
T
Y
D
FE
R
LME
GA
K
LLK
C
S
E
F
GDAI
I
K
fig|714962.3.peg.1267
Escherichia coli IHE3034 (25-414/416)
E
N
PI
I
P
Y
I
E
GDGIG
V
D
V
T
P
AM
LKV
V
DAA
V
E
K
A
YKG
ERK
IS
WMEIYT
G
EKS
-
TQV
Y
GQ
D
VW
LP
AE
T
L
D
LIR
E
Y
RV
AI
K
G
-
--
---
-
----
P
L
TT
P
VG
G
G
IRSLNV
A
LRQE
L
DLY
I
C
LRPVR
Y
YQG
T
P
--
S
P
V
-
-
-
K
H
P
ELT
D
MVI
F
REN
S
E
D
IY
-
AGIE
WK
AD
S
A
-
D
A
EKVI
K--
-
F
L
R
E
EM
GVKKIRFPEHCGIGIKPCSEEGT
KR
L
V
R
A
A
I
E
Y
A
IA
N
D
R
DS
VT
L
VH
K
G
N
I
M
KF
T
EGA
F
K
D
W
G
YQ
L
A
R
E
EFGGELIDGGPWLKVKNPNTGK
EI
VIKDVI
A
D
AFLQ
Q
I
L
LR
P
A
E
Y
DVI
A
C
M
NL
N
GD
YI
SD
AL
AA
Q
V
G
G
IGIAP
G
AN
IG
D
E
C-
-
-
A
LFE
A
T
HG
T
AP
KY
AG
QDKV
NP
GS
I
ILS
A
E
MMLRH
M
G
--
-
-
-
WTE
AA
DL
I
VK
GM
E
G
AI
NA
K
TV
T
Y
D
FE
R
LME
GA
K
LLK
C
S
E
F
GDAI
I
K
fig|595495.4.peg.1794
Escherichia coli KO11 (25-414/416)
E
N
PI
I
P
Y
I
E
GDGIG
V
D
V
T
P
AM
LKV
V
DAA
V
E
K
A
YKG
ERK
IS
WMEIYT
G
EKS
-
TQV
Y
GQ
D
VW
LP
AE
T
L
D
LIR
E
Y
RV
AI
K
G
-
--
---
-
----
P
L
TT
P
VG
G
G
IRSLNV
A
LRQE
L
DLY
I
C
LRPVR
Y
YQG
T
P
--
S
P
V
-
-
-
K
H
P
ELT
D
MVI
F
REN
S
E
D
IY
-
AGIE
WK
AD
S
A
-
D
A
EKVI
K--
-
F
L
R
E
EM
GVKKIRFPEHCGIGIKPCSEEGT
KR
L
V
R
A
A
I
E
Y
A
IA
N
D
R
DS
VT
L
VH
K
G
N
I
M
KF
T
EGA
F
K
D
W
G
YQ
L
A
R
E
EFGGELIDGGPWLKVKNPNTGK
EI
VIKDVI
A
D
AFLQ
Q
I
L
LR
P
A
E
Y
DVI
A
C
M
NL
N
GD
YI
SD
AL
AA
Q
V
G
G
IGIAP
G
AN
IG
D
E
C-
-
-
A
LFE
A
T
HG
T
AP
KY
AG
QDKV
NP
GS
I
ILS
A
E
MMLRH
M
G
--
-
-
-
WTE
AA
DL
I
VK
GM
E
G
AI
NA
K
TV
T
Y
D
FE
R
LME
GA
K
LLK
C
S
E
F
GDAI
I
K
fig|656417.3.peg.1378
Escherichia coli M605 (25-414/416)
E
N
PI
I
P
Y
I
E
GDGIG
V
D
V
T
P
AM
LKV
V
DAA
V
E
K
A
YKG
ERK
IS
WMEIYT
G
EKS
-
TQV
Y
GQ
D
VW
LP
AE
T
L
D
LIR
E
Y
RV
AI
K
G
-
--
---
-
----
P
L
TT
P
VG
G
G
IRSLNV
A
LRQE
L
DLY
I
C
LRPVR
Y
YQG
T
P
--
S
P
V
-
-
-
K
H
P
ELT
D
MVI
F
REN
S
E
D
IY
-
AGIE
WK
AD
S
A
-
D
A
EKVI
K--
-
F
L
R
E
EM
GVKKIRFPEHCGIGIKPCSEEGT
KR
L
V
R
A
A
I
E
Y
A
IA
N
D
R
DS
VT
L
VH
K
G
N
I
M
KF
T
EGA
F
K
D
W
G
YQ
L
A
R
E
EFGGELIDGGPWLKVKNPNTGK
EI
VIKDVI
A
D
AFLQ
Q
I
L
LR
P
A
E
Y
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A
C
M
NL
N
GD
YI
SD
AL
AA
Q
V
G
G
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G
AN
IG
D
E
C-
-
-
A
LFE
A
T
HG
T
AP
KY
AG
QDKV
NP
GS
I
ILS
A
E
MMLRH
M
G
--
-
-
-
WTE
AA
DL
I
VK
GM
E
G
AI
NA
K
TV
T
Y
D
FE
R
LME
GA
K
LLK
C
S
E
F
GDAI
I
K
fig|656419.3.peg.1482
Escherichia coli M718 (25-414/416)
E
N
PI
I
P
Y
I
E
GDGIG
V
D
V
T
P
AM
LKV
V
DAA
V
E
K
A
YKG
ERK
IS
WMEIYT
G
EKS
-
TQV
Y
GQ
D
VW
LP
AE
T
L
D
LIR
E
Y
RV
AI
K
G
-
--
---
-
----
P
L
TT
P
VG
G
G
IRSLNV
A
LRQE
L
DLY
I
C
LRPVR
Y
YQG
T
P
--
S
P
V
-
-
-
K
H
P
ELT
D
MVI
F
REN
S
E
D
IY
-
AGIE
WK
AD
S
A
-
D
A
EKVI
K--
-
F
L
R
E
EM
GVKKIRFPEHCGIGIKPCSEEGT
KR
L
V
R
A
A
I
E
Y
A
IA
N
D
R
DS
VT
L
VH
K
G
N
I
M
KF
T
EGA
F
K
D
W
G
YQ
L
A
R
E
EFGGELIDGGPWLKVKNPNTGK
EI
VIKDVI
A
D
AFLQ
Q
I
L
LR
P
A
E
Y
DVI
A
C
M
NL
N
GD
YI
SD
AL
AA
Q
V
G
G
IGIAP
G
AN
IG
D
E
C-
-
-
A
LFE
A
T
HG
T
AP
KY
AG
QDKV
NP
GS
I
ILS
A
E
MMLRH
M
G
--
-
-
-
WTE
AA
DL
I
VK
GM
E
G
AI
NA
K
TV
T
Y
D
FE
R
LME
GA
K
LLK
C
S
E
F
GDAI
I
K
fig|679207.4.peg.1854
Escherichia coli MS 107-1 (25-414/416)
E
N
PI
I
P
Y
I
E
GDGIG
V
D
V
T
P
AM
LKV
V
DAA
V
E
K
A
YKG
ERK
IS
WMEIYT
G
EKS
-
TQV
Y
GQ
D
VW
LP
AE
T
L
D
LIR
E
Y
RV
AI
K
G
-
--
---
-
----
P
L
TT
P
VG
G
G
IRSLNV
A
LRQE
L
DLY
I
C
LRPVR
Y
YQG
T
P
--
S
P
V
-
-
-
K
H
P
ELT
D
MVI
F
REN
S
E
D
IY
-
AGIE
WK
AD
S
A
-
D
A
EKVI
K--
-
F
L
R
E
EM
GVKKIRFPEHCGIGIKPCSEEGT
KR
L
V
R
A
A
I
E
Y
A
IA
N
D
R
DS
VT
L
VH
K
G
N
I
M
KF
T
EGA
F
K
D
W
G
YQ
L
A
R
E
EFGGELIDGGPWLKVKNPNTGK
EI
VIKDVI
A
D
AFLQ
Q
I
L
LR
P
A
E
Y
DVI
A
C
M
NL
N
GD
YI
SD
AL
AA
Q
V
G
G
IGIAP
G
AN
IG
D
E
C-
-
-
A
LFE
A
T
HG
T
AP
KY
AG
QDKV
NP
GS
I
ILS
A
E
MMLRH
M
G
--
-
-
-
WTE
AA
DL
I
VK
GM
E
G
AI
NA
K
TV
T
Y
D
FE
R
LME
GA
K
LLK
C
S
E
F
GDAI
I
K
fig|679206.4.peg.850
Escherichia coli MS 119-7 (25-414/416)
E
N
PI
I
P
Y
I
E
GDGIG
V
D
V
T
P
AM
LKV
V
DAA
V
E
K
A
YKG
ERK
IS
WMEIYT
G
EKS
-
TQV
Y
GQ
D
VW
LP
AE
T
L
D
LIR
E
Y
RV
AI
K
G
-
--
---
-
----
P
L
TT
P
VG
G
G
IRSLNV
A
LRQE
L
DLY
I
C
LRPVR
Y
YQG
T
P
--
S
P
V
-
-
-
K
H
P
ELT
D
MVI
F
REN
S
E
D
IY
-
AGIE
WK
AD
S
A
-
D
A
EKVI
K--
-
F
L
R
E
EM
GVKKIRFPEHCGIGIKPCSEEGT
KR
L
V
R
A
A
I
E
Y
A
IA
N
D
R
DS
VT
L
VH
K
G
N
I
M
KF
T
EGA
F
K
D
W
G
YQ
L
A
R
E
EFGGELIDGGPWLKVKNPNTGK
EI
VIKDVI
A
D
AFLQ
Q
I
L
LR
P
A
E
Y
DVI
A
C
M
NL
N
GD
YI
SD
AL
AA
Q
V
G
G
IGIAP
G
AN
IG
D
E
C-
-
-
A
LFE
A
T
HG
T
AP
KY
AG
QDKV
NP
GS
I
ILS
A
E
MMLRH
M
G
--
-
-
-
WTE
AA
DL
I
VK
GM
E
G
AI
NA
K
TV
T
Y
D
FE
R
LME
GA
K
LLK
C
S
E
F
GDAI
I
K
fig|679205.4.peg.4529
Escherichia coli MS 124-1 (25-414/416)
E
N
PI
I
P
Y
I
E
GDGIG
V
D
V
T
P
AM
LKV
V
DAA
V
E
K
A
YKG
ERK
IS
WMEIYT
G
EKS
-
TQV
Y
GQ
D
VW
LP
AE
T
L
D
LIR
E
Y
RV
AI
K
G
-
--
---
-
----
P
L
TT
P
VG
G
G
IRSLNV
A
LRQE
L
DLY
I
C
LRPVR
Y
YQG
T
P
--
S
P
V
-
-
-
K
H
P
ELT
D
MVI
F
REN
S
E
D
IY
-
AGIE
WK
AD
S
A
-
D
A
EKVI
K--
-
F
L
R
E
EM
GVKKIRFPEHCGIGIKPCSEEGT
KR
L
V
R
A
A
I
E
Y
A
IA
N
D
R
DS
VT
L
VH
K
G
N
I
M
KF
T
EGA
F
K
D
W
G
YQ
L
A
R
E
EFGGELIDGGPWLKVKNPNTGK
EI
VIKDVI
A
D
AFLQ
Q
I
L
LR
P
A
E
Y
DVI
A
C
M
NL
N
GD
YI
SD
AL
AA
Q
V
G
G
IGIAP
G
AN
IG
D
E
C-
-
-
A
LFE
A
T
HG
T
AP
KY
AG
QDKV
NP
GS
I
ILS
A
E
MMLRH
M
G
--
-
-
-
WTE
AA
DL
I
VK
GM
E
G
AI
NA
K
TV
T
Y
D
FE
R
LME
GA
K
LLK
C
S
E
F
GDAI
I
K
fig|679204.3.peg.3604
Escherichia coli MS 145-7 (25-414/416)
E
N
PI
I
P
Y
I
E
GDGIG
V
D
V
T
P
AM
LKV
V
DAA
V
E
K
A
YKG
ERK
IS
WMEIYT
G
EKS
-
TQV
Y
GQ
D
VW
LP
AE
T
L
D
LIR
E
Y
RV
AI
K
G
-
--
---
-
----
P
L
TT
P
VG
G
G
IRSLNV
A
LRQE
L
DLY
I
C
LRPVR
Y
YQG
T
P
--
S
P
V
-
-
-
K
H
P
ELT
D
MVI
F
REN
S
E
D
IY
-
AGIE
WK
AD
S
A
-
D
A
EKVI
K--
-
F
L
R
E
EM
GVKKIRFPEHCGIGIKPCSEEGT
KR
L
V
R
A
A
I
E
Y
A
IA
N
D
R
DS
VT
L
VH
K
G
N
I
M
KF
T
EGA
F
K
D
W
G
YQ
L
A
R
E
EFGGELIDGGPWLKVKNPNTGK
EI
VIKDVI
A
D
AFLQ
Q
I
L
LR
P
A
E
Y
DVI
A
C
M
NL
N
GD
YI
SD
AL
AA
Q
V
G
G
IGIAP
G
AN
IG
D
E
C-
-
-
A
LFE
A
T
HG
T
AP
KY
AG
QDKV
NP
GS
I
ILS
A
E
MMLRH
M
G
--
-
-
-
WTE
AA
DL
I
VK
GM
E
G
AI
NA
K
TV
T
Y
D
FE
R
LME
GA
K
LLK
C
S
E
F
GDAI
I
K
fig|749546.3.peg.4713
Escherichia coli MS 185-1 (25-414/416)
E
N
PI
I
P
Y
I
E
GDGIG
V
D
V
T
P
AM
LKV
V
DAA
V
E
K
A
YKG
ERK
IS
WMEIYT
G
EKS
-
TQV
Y
GQ
D
VW
LP
AE
T
L
D
LIR
E
Y
RV
AI
K
G
-
--
---
-
----
P
L
TT
P
VG
G
G
IRSLNV
A
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L
DLY
I
C
LRPVR
Y
YQG
T
P
--
S
P
V
-
-
-
K
H
P
ELT
D
MVI
F
REN
S
E
D
IY
-
AGIE
WK
AD
S
A
-
D
A
EKVI
K--
-
F
L
R
E
EM
GVKKIRFPEHCGIGIKPCSEEGT
KR
L
V
R
A
A
I
E
Y
A
IA
N
D
R
DS
VT
L
VH
K
G
N
I
M
KF
T
EGA
F
K
D
W
G
YQ
L
A
R
E
EFGGELIDGGPWLKVKNPNTGK
EI
VIKDVI
A
D
AFLQ
Q
I
L
LR
P
A
E
Y
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A
C
M
NL
N
GD
YI
SD
AL
AA
Q
V
G
G
IGIAP
G
AN
IG
D
E
C-
-
-
A
LFE
A
T
HG
T
AP
KY
AG
QDKV
NP
GS
I
ILS
A
E
MMLRH
M
G
--
-
-
-
WTE
AA
DL
I
VK
GM
E
G
AI
NA
K
TV
T
Y
D
FE
R
LME
GA
K
LLK
C
S
E
F
GDAI
I
K
fig|749547.3.peg.647
Escherichia coli MS 187-1 (25-414/416)
E
N
PI
I
P
Y
I
E
GDGIG
V
D
V
T
P
AM
LKV
V
DAA
V
E
K
A
YKG
ERK
IS
WMEIYT
G
EKS
-
TQV
Y
GQ
D
VW
LP
AE
T
L
D
LIR
E
Y
RV
AI
K
G
-
--
---
-
----
P
L
TT
P
VG
G
G
IRSLNV
A
LRQE
L
DLY
I
C
LRPVR
Y
YQG
T
P
--
S
P
V
-
-
-
K
H
P
ELT
D
MVI
F
REN
S
E
D
IY
-
AGIE
WK
AD
S
A
-
D
A
EKVI
K--
-
F
L
R
E
EM
GVKKIRFPEHCGIGIKPCSEEGT
KR
L
V
R
A
A
I
E
Y
A
IA
N
D
R
DS
VT
L
VH
K
G
N
I
M
KF
T
EGA
F
K
D
W
G
YQ
L
A
R
E
EFGGELIDGGPWLKVKNPNTGK
EI
VIKDVI
A
D
AFLQ
Q
I
L
LR
P
A
E
Y
DVI
A
C
M
NL
N
GD
YI
SD
AL
AA
Q
V
G
G
IGIAP
G
AN
IG
D
E
C-
-
-
A
LFE
A
T
HG
T
AP
KY
AG
QDKV
NP
GS
I
ILS
A
E
MMLRH
M
G
--
-
-
-
WTE
AA
DL
I
VK
GM
E
G
AI
NA
K
TV
T
Y
D
FE
R
LME
GA
K
LLK
C
S
E
F
GDAI
I
K
fig|749550.3.peg.2028
Escherichia coli MS 200-1 (25-414/416)
E
N
PI
I
P
Y
I
E
GDGIG
V
D
V
T
P
AM
LKV
V
DAA
V
E
K
A
YKG
ERK
IS
WMEIYT
G
EKS
-
TQV
Y
GQ
D
VW
LP
AE
T
L
D
LIR
E
Y
RV
AI
K
G
-
--
---
-
----
P
L
TT
P
VG
G
G
IRSLNV
A
LRQE
L
DLY
I
C
LRPVR
Y
YQG
T
P
--
S
P
V
-
-
-
K
H
P
ELT
D
MVI
F
REN
S
E
D
IY
-
AGIE
WK
AD
S
A
-
D
A
EKVI
K--
-
F
L
R
E
EM
GVKKIRFPEHCGIGIKPCSEEGT
KR
L
V
R
A
A
I
E
Y
A
IA
N
D
R
DS
VT
L
VH
K
G
N
I
M
KF
T
EGA
F
K
D
W
G
YQ
L
A
R
E
EFGGELIDGGPWLKVKNPNTGK
EI
VIKDVI
A
D
AFLQ
Q
I
L
LR
P
A
E
Y
DVI
A
C
M
NL
N
GD
YI
SD
AL
AA
Q
V
G
G
IGIAP
G
AN
IG
D
E
C-
-
-
A
LFE
A
T
HG
T
AP
KY
AG
QDKV
NP
GS
I
ILS
A
E
MMLRH
M
G
--
-
-
-
WTE
AA
DL
I
VK
GM
E
G
AI
NA
K
TV
T
Y
D
FE
R
LME
GA
K
LLK
C
S
E
F
GDAI
I
K
fig|749527.3.peg.3388
Escherichia coli MS 21-1 (25-414/416)
E
N
PI
I
P
Y
I
E
GDGIG
V
D
V
T
P
AM
LKV
V
DAA
V
E
K
A
YKG
ERK
IS
WMEIYT
G
EKS
-
TQV
Y
GQ
D
VW
LP
AE
T
L
D
LIR
E
Y
RV
AI
K
G
-
--
---
-
----
P
L
TT
P
VG
G
G
IRSLNV
A
LRQE
L
DLY
I
C
LRPVR
Y
YQG
T
P
--
S
P
V
-
-
-
K
H
P
ELT
D
MVI
F
REN
S
E
D
IY
-
AGIE
WK
AD
S
A
-
D
A
EKVI
K--
-
F
L
R
E
EM
GVKKIRFPEHCGIGIKPCSEEGT
KR
L
V
R
A
A
I
E
Y
A
IA
N
D
R
DS
VT
L
VH
K
G
N
I
M
KF
T
EGA
F
K
D
W
G
YQ
L
A
R
E
EFGGELIDGGPWLKVKNPNTGK
EI
VIKDVI
A
D
AFLQ
Q
I
L
LR
P
A
E
Y
DVI
A
C
M
NL
N
GD
YI
SD
AL
AA
Q
V
G
G
IGIAP
G
AN
IG
D
E
C-
-
-
A
LFE
A
T
HG
T
AP
KY
AG
QDKV
NP
GS
I
ILS
A
E
MMLRH
M
G
--
-
-
-
WTE
AA
DL
I
VK
GM
E
G
AI
NA
K
TV
T
Y
D
FE
R
LME
GA
K
LLK
C
S
E
F
GDAI
I
K
fig|749528.3.peg.1012
Escherichia coli MS 45-1 (25-414/416)
E
N
PI
I
P
Y
I
E
GDGIG
V
D
V
T
P
AM
LKV
V
DAA
V
E
K
A
YKG
ERK
IS
WMEIYT
G
EKS
-
TQV
Y
GQ
D
VW
LP
AE
T
L
D
LIR
E
Y
RV
AI
K
G
-
--
---
-
----
P
L
TT
P
VG
G
G
IRSLNV
A
LRQE
L
DLY
I
C
LRPVR
Y
YQG
T
P
--
S
P
V
-
-
-
K
H
P
ELT
D
MVI
F
REN
S
E
D
IY
-
AGIE
WK
AD
S
A
-
D
A
EKVI
K--
-
F
L
R
E
EM
GVKKIRFPEHCGIGIKPCSEEGT
KR
L
V
R
A
A
I
E
Y
A
IA
N
D
R
DS
VT
L
VH
K
G
N
I
M
KF
T
EGA
F
K
D
W
G
YQ
L
A
R
E
EFGGELIDGGPWLKVKNPNTGK
EI
VIKDVI
A
D
AFLQ
Q
I
L
LR
P
A
E
Y
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A
C
M
NL
N
GD
YI
SD
AL
AA
Q
V
G
G
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G
AN
IG
D
E
C-
-
-
A
LFE
A
T
HG
T
AP
KY
AG
QDKV
NP
GS
I
ILS
A
E
MMLRH
M
G
--
-
-
-
WTE
AA
DL
I
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GM
E
G
AI
NA
K
TV
T
Y
D
FE
R
LME
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K
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C
S
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F
GDAI
I
K
fig|749531.3.peg.3715
Escherichia coli MS 69-1 (25-414/416)
E
N
PI
I
P
Y
I
E
GDGIG
V
D
V
T
P
AM
LKV
V
DAA
V
E
K
A
YKG
ERK
IS
WMEIYT
G
EKS
-
TQV
Y
GQ
D
VW
LP
AE
T
L
D
LIR
E
Y
RV
AI
K
G
-
--
---
-
----
P
L
TT
P
VG
G
G
IRSLNV
A
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L
DLY
I
C
LRPVR
Y
YQG
T
P
--
S
P
V
-
-
-
K
H
P
ELT
D
MVI
F
REN
S
E
D
IY
-
AGIE
WK
AD
S
A
-
D
A
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K--
-
F
L
R
E
EM
GVKKIRFPEHCGIGIKPCSEEGT
KR
L
V
R
A
A
I
E
Y
A
IA
N
D
R
DS
VT
L
VH
K
G
N
I
M
KF
T
EGA
F
K
D
W
G
YQ
L
A
R
E
EFGGELIDGGPWLKVKNPNTGK
EI
VIKDVI
A
D
AFLQ
Q
I
L
LR
P
A
E
Y
DVI
A
C
M
NL
N
GD
YI
SD
AL
AA
Q
V
G
G
IGIAP
G
AN
IG
D
E
C-
-
-
A
LFE
A
T
HG
T
AP
KY
AG
QDKV
NP
GS
I
ILS
A
E
MMLRH
M
G
--
-
-
-
WTE
AA
DL
I
VK
GM
E
G
AI
NA
K
TV
T
Y
D
FE
R
LME
GA
K
LLK
C
S
E
F
GDAI
I
K
fig|749533.3.peg.4639
Escherichia coli MS 84-1 (25-414/416)
E
N
PI
I
P
Y
I
E
GDGIG
V
D
V
T
P
AM
LKV
V
DAA
V
E
K
A
YKG
ERK
IS
WMEIYT
G
EKS
-
TQV
Y
GQ
D
VW
LP
AE
T
L
D
LIR
E
Y
RV
AI
K
G
-
--
---
-
----
P
L
TT
P
VG
G
G
IRSLNV
A
LRQE
L
DLY
I
C
LRPVR
Y
YQG
T
P
--
S
P
V
-
-
-
K
H
P
ELT
D
MVI
F
REN
S
E
D
IY
-
AGIE
WK
AD
S
A
-
D
A
EKVI
K--
-
F
L
R
E
EM
GVKKIRFPEHCGIGIKPCSEEGT
KR
L
V
R
A
A
I
E
Y
A
IA
N
D
R
DS
VT
L
VH
K
G
N
I
M
KF
T
EGA
F
K
D
W
G
YQ
L
A
R
E
EFGGELIDGGPWLKVKNPNTGK
EI
VIKDVI
A
D
AFLQ
Q
I
L
LR
P
A
E
Y
DVI
A
C
M
NL
N
GD
YI
SD
AL
AA
Q
V
G
G
IGIAP
G
AN
IG
D
E
C-
-
-
A
LFE
A
T
HG
T
AP
KY
AG
QDKV
NP
GS
I
ILS
A
E
MMLRH
M
G
--
-
-
-
WTE
AA
DL
I
VK
GM
E
G
AI
NA
K
TV
T
Y
D
FE
R
LME
GA
K
LLK
C
S
E
F
GDAI
I
K
fig|753642.3.peg.2173
Escherichia coli NC101 (25-414/416)
E
N
PI
I
P
Y
I
E
GDGIG
V
D
V
T
P
AM
LKV
V
DAA
V
E
K
A
YKG
ERK
IS
WMEIYT
G
EKS
-
TQV
Y
GQ
D
VW
LP
AE
T
L
D
LIR
E
Y
RV
AI
K
G
-
--
---
-
----
P
L
TT
P
VG
G
G
IRSLNV
A
LRQE
L
DLY
I
C
LRPVR
Y
YQG
T
P
--
S
P
V
-
-
-
K
H
P
ELT
D
MVI
F
REN
S
E
D
IY
-
AGIE
WK
AD
S
A
-
D
A
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K--
-
F
L
R
E
EM
GVKKIRFPEHCGIGIKPCSEEGT
KR
L
V
R
A
A
I
E
Y
A
IA
N
D
R
DS
VT
L
VH
K
G
N
I
M
KF
T
EGA
F
K
D
W
G
YQ
L
A
R
E
EFGGELIDGGPWLKVKNPNTGK
EI
VIKDVI
A
D
AFLQ
Q
I
L
LR
P
A
E
Y
DVI
A
C
M
NL
N
GD
YI
SD
AL
AA
Q
V
G
G
IGIAP
G
AN
IG
D
E
C-
-
-
A
LFE
A
T
HG
T
AP
KY
AG
QDKV
NP
GS
I
ILS
A
E
MMLRH
M
G
--
-
-
-
WTE
AA
DL
I
VK
GM
E
G
AI
NA
K
TV
T
Y
D
FE
R
LME
GA
K
LLK
C
S
E
F
GDAI
I
K
fig|585395.4.peg.1323
Escherichia coli O103:H2 str. 12009 (25-414/416)
E
N
PI
I
P
Y
I
E
GDGIG
V
D
V
T
P
AM
LKV
V
DAA
V
E
K
A
YKG
ERK
IS
WMEIYT
G
EKS
-
TQV
Y
GQ
D
VW
LP
AE
T
L
D
LIR
E
Y
RV
AI
K
G
-
--
---
-
----
P
L
TT
P
VG
G
G
IRSLNV
A
LRQE
L
DLY
I
C
LRPVR
Y
YQG
T
P
--
S
P
V
-
-
-
K
H
P
ELT
D
MVI
F
REN
S
E
D
IY
-
AGIE
WK
AD
S
A
-
D
A
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K--
-
F
L
R
E
EM
GVKKIRFPEHCGIGIKPCSEEGT
KR
L
V
R
A
A
I
E
Y
A
IA
N
D
R
DS
VT
L
VH
K
G
N
I
M
KF
T
EGA
F
K
D
W
G
YQ
L
A
R
E
EFGGELIDGGPWLKVKNPNTGK
EI
VIKDVI
A
D
AFLQ
Q
I
L
LR
P
A
E
Y
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A
C
M
NL
N
GD
YI
SD
AL
AA
Q
V
G
G
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G
AN
IG
D
E
C-
-
-
A
LFE
A
T
HG
T
AP
KY
AG
QDKV
NP
GS
I
ILS
A
E
MMLRH
M
G
--
-
-
-
WTE
AA
DL
I
VK
GM
E
G
AI
NA
K
TV
T
Y
D
FE
R
LME
GA
K
LLK
C
S
E
F
GDAI
I
K
fig|585396.4.peg.1542
Escherichia coli O111:H- str. 11128 (25-414/416)
E
N
PI
I
P
Y
I
E
GDGIG
V
D
V
T
P
AM
LKV
V
DAA
V
E
K
A
YKG
ERK
IS
WMEIYT
G
EKS
-
TQV
Y
GQ
D
VW
LP
AE
T
L
D
LIR
E
Y
RV
AI
K
G
-
--
---
-
----
P
L
TT
P
VG
G
G
IRSLNV
A
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L
DLY
I
C
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Y
YQG
T
P
--
S
P
V
-
-
-
K
H
P
ELT
D
MVI
F
REN
S
E
D
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-
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WK
AD
S
A
-
D
A
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K--
-
F
L
R
E
EM
GVKKIRFPEHCGIGIKPCSEEGT
KR
L
V
R
A
A
I
E
Y
A
IA
N
D
R
DS
VT
L
VH
K
G
N
I
M
KF
T
EGA
F
K
D
W
G
YQ
L
A
R
E
EFGGELIDGGPWLKVKNPNTGK
EI
VIKDVI
A
D
AFLQ
Q
I
L
LR
P
A
E
Y
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A
C
M
NL
N
GD
YI
SD
AL
AA
Q
V
G
G
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G
AN
IG
D
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C-
-
-
A
LFE
A
T
HG
T
AP
KY
AG
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NP
GS
I
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A
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MMLRH
M
G
--
-
-
-
WTE
AA
DL
I
VK
GM
E
G
AI
NA
K
TV
T
Y
D
FE
R
LME
GA
K
LLK
C
S
E
F
GDAI
I
K
fig|573235.3.peg.1694
Escherichia coli O26:H11 str. 11368 (25-414/416)
E
N
PI
I
P
Y
I
E
GDGIG
V
D
V
T
P
AM
LKV
V
DAA
V
E
K
A
YKG
ERK
IS
WMEIYT
G
EKS
-
TQV
Y
GQ
D
VW
LP
AE
T
L
D
LIR
E
Y
RV
AI
K
G
-
--
---
-
----
P
L
TT
P
VG
G
G
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A
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L
DLY
I
C
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Y
YQG
T
P
--
S
P
V
-
-
-
K
H
P
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D
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F
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S
E
D
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-
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WK
AD
S
A
-
D
A
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K--
-
F
L
R
E
EM
GVKKIRFPEHCGIGIKPCSEEGT
KR
L
V
R
A
A
I
E
Y
A
IA
N
D
R
DS
VT
L
VH
K
G
N
I
M
KF
T
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F
K
D
W
G
YQ
L
A
R
E
EFGGELIDGGPWLKVKNPNTGK
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VIKDVI
A
D
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Q
I
L
LR
P
A
E
Y
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A
C
M
NL
N
GD
YI
SD
AL
AA
Q
V
G
G
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G
AN
IG
D
E
C-
-
-
A
LFE
A
T
HG
T
AP
KY
AG
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NP
GS
I
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A
E
MMLRH
M
G
--
-
-
-
WTE
AA
DL
I
VK
GM
E
G
AI
NA
K
TV
T
Y
D
FE
R
LME
GA
K
LLK
C
S
E
F
GDAI
I
K
fig|685038.3.peg.1105
Escherichia coli O83:H1 str. NRG 857C (25-414/416)
E
N
PI
I
P
Y
I
E
GDGIG
V
D
V
T
P
AM
LKV
V
DAA
V
E
K
A
YKG
ERK
IS
WMEIYT
G
EKS
-
TQV
Y
GQ
D
VW
LP
AE
T
L
D
LIR
E
Y
RV
AI
K
G
-
--
---
-
----
P
L
TT
P
VG
G
G
IRSLNV
A
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L
DLY
I
C
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Y
YQG
T
P
--
S
P
V
-
-
-
K
H
P
ELT
D
MVI
F
REN
S
E
D
IY
-
AGIE
WK
AD
S
A
-
D
A
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K--
-
F
L
R
E
EM
GVKKIRFPEHCGIGIKPCSEEGT
KR
L
V
R
A
A
I
E
Y
A
IA
N
D
R
DS
VT
L
VH
K
G
N
I
M
KF
T
EGA
F
K
D
W
G
YQ
L
A
R
E
EFGGELIDGGPWLKVKNPNTGK
EI
VIKDVI
A
D
AFLQ
Q
I
L
LR
P
A
E
Y
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A
C
M
NL
N
GD
YI
SD
AL
AA
Q
V
G
G
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G
AN
IG
D
E
C-
-
-
A
LFE
A
T
HG
T
AP
KY
AG
QDKV
NP
GS
I
ILS
A
E
MMLRH
M
G
--
-
-
-
WTE
AA
DL
I
VK
GM
E
G
AI
NA
K
TV
T
Y
D
FE
R
LME
GA
K
LLK
C
S
E
F
GDAI
I
K
fig|585035.6.peg.1157
Escherichia coli S88 (25-414/416)
E
N
PI
I
P
Y
I
E
GDGIG
V
D
V
T
P
AM
LKV
V
DAA
V
E
K
A
YKG
ERK
IS
WMEIYT
G
EKS
-
TQV
Y
GQ
D
VW
LP
AE
T
L
D
LIR
E
Y
RV
AI
K
G
-
--
---
-
----
P
L
TT
P
VG
G
G
IRSLNV
A
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L
DLY
I
C
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Y
YQG
T
P
--
S
P
V
-
-
-
K
H
P
ELT
D
MVI
F
REN
S
E
D
IY
-
AGIE
WK
AD
S
A
-
D
A
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K--
-
F
L
R
E
EM
GVKKIRFPEHCGIGIKPCSEEGT
KR
L
V
R
A
A
I
E
Y
A
IA
N
D
R
DS
VT
L
VH
K
G
N
I
M
KF
T
EGA
F
K
D
W
G
YQ
L
A
R
E
EFGGELIDGGPWLKVKNPNTGK
EI
VIKDVI
A
D
AFLQ
Q
I
L
LR
P
A
E
Y
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A
C
M
NL
N
GD
YI
SD
AL
AA
Q
V
G
G
IGIAP
G
AN
IG
D
E
C-
-
-
A
LFE
A
T
HG
T
AP
KY
AG
QDKV
NP
GS
I
ILS
A
E
MMLRH
M
G
--
-
-
-
WTE
AA
DL
I
VK
GM
E
G
AI
NA
K
TV
T
Y
D
FE
R
LME
GA
K
LLK
C
S
E
F
GDAI
I
K
fig|409438.11.peg.1340
Escherichia coli SE11 (25-414/416)
E
N
PI
I
P
Y
I
E
GDGIG
V
D
V
T
P
AM
LKV
V
DAA
V
E
K
A
YKG
ERK
IS
WMEIYT
G
EKS
-
TQV
Y
GQ
D
VW
LP
AE
T
L
D
LIR
E
Y
RV
AI
K
G
-
--
---
-
----
P
L
TT
P
VG
G
G
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A
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L
DLY
I
C
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Y
YQG
T
P
--
S
P
V
-
-
-
K
H
P
ELT
D
MVI
F
REN
S
E
D
IY
-
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WK
AD
S
A
-
D
A
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K--
-
F
L
R
E
EM
GVKKIRFPEHCGIGIKPCSEEGT
KR
L
V
R
A
A
I
E
Y
A
IA
N
D
R
DS
VT
L
VH
K
G
N
I
M
KF
T
EGA
F
K
D
W
G
YQ
L
A
R
E
EFGGELIDGGPWLKVKNPNTGK
EI
VIKDVI
A
D
AFLQ
Q
I
L
LR
P
A
E
Y
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A
C
M
NL
N
GD
YI
SD
AL
AA
Q
V
G
G
IGIAP
G
AN
IG
D
E
C-
-
-
A
LFE
A
T
HG
T
AP
KY
AG
QDKV
NP
GS
I
ILS
A
E
MMLRH
M
G
--
-
-
-
WTE
AA
DL
I
VK
GM
E
G
AI
NA
K
TV
T
Y
D
FE
R
LME
GA
K
LLK
C
S
E
F
GDAI
I
K
fig|431946.3.peg.1085
Escherichia coli SE15 (25-414/416)
E
N
PI
I
P
Y
I
E
GDGIG
V
D
V
T
P
AM
LKV
V
DAA
V
E
K
A
YKG
ERK
IS
WMEIYT
G
EKS
-
TQV
Y
GQ
D
VW
LP
AE
T
L
D
LIR
E
Y
RV
AI
K
G
-
--
---
-
----
P
L
TT
P
VG
G
G
IRSLNV
A
LRQE
L
DLY
I
C
LRPVR
Y
YQG
T
P
--
S
P
V
-
-
-
K
H
P
ELT
D
MVI
F
REN
S
E
D
IY
-
AGIE
WK
AD
S
A
-
D
A
EKVI
K--
-
F
L
R
E
EM
GVKKIRFPEHCGIGIKPCSEEGT
KR
L
V
R
A
A
I
E
Y
A
IA
N
D
R
DS
VT
L
VH
K
G
N
I
M
KF
T
EGA
F
K
D
W
G
YQ
L
A
R
E
EFGGELIDGGPWLKVKNPNTGK
EI
VIKDVI
A
D
AFLQ
Q
I
L
LR
P
A
E
Y
DVI
A
C
M
NL
N
GD
YI
SD
AL
AA
Q
V
G
G
IGIAP
G
AN
IG
D
E
C-
-
-
A
LFE
A
T
HG
T
AP
KY
AG
QDKV
NP
GS
I
ILS
A
E
MMLRH
M
G
--
-
-
-
WTE
AA
DL
I
VK
GM
E
G
AI
NA
K
TV
T
Y
D
FE
R
LME
GA
K
LLK
C
S
E
F
GDAI
I
K
fig|439855.10.peg.2147
Escherichia coli SMS-3-5 (25-414/416)
E
N
PI
I
P
Y
I
E
GDGIG
V
D
V
T
P
AM
LKV
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AI
K
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-
--
---
-
----
P
L
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G
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L
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--
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-
-
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D
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WK
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S
A
-
D
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K--
-
F
L
R
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EM
GVKKIRFPEHCGIGIKPCSEEGT
KR
L
V
R
A
A
I
E
Y
A
IA
N
D
R
DS
VT
L
VH
K
G
N
I
M
KF
T
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F
K
D
W
G
YQ
L
A
R
E
EFGGELIDGGPWLKVKNPNTGK
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A
D
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Q
I
L
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A
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A
C
M
NL
N
GD
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AL
AA
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V
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AN
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C-
-
-
A
LFE
A
T
HG
T
AP
KY
AG
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NP
GS
I
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G
--
-
-
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AA
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TV
T
Y
D
FE
R
LME
GA
K
LLK
C
S
E
F
GDAI
I
K
fig|656437.3.peg.1284
Escherichia coli TA143 (25-414/416)
E
N
PI
I
P
Y
I
E
GDGIG
V
D
V
T
P
AM
LKV
V
DAA
V
E
K
A
YKG
ERK
IS
WMEIYT
G
EKS
-
TQV
Y
GQ
D
VW
LP
AE
T
L
D
LIR
E
Y
RV
AI
K
G
-
--
---
-
----
P
L
TT
P
VG
G
G
IRSLNV
A
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L
DLY
I
C
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Y
YQG
T
P
--
S
P
V
-
-
-
K
H
P
ELT
D
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F
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S
E
D
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-
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WK
AD
S
A
-
D
A
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K--
-
F
L
R
E
EM
GVKKIRFPEHCGIGIKPCSEEGT
KR
L
V
R
A
A
I
E
Y
A
IA
N
D
R
DS
VT
L
VH
K
G
N
I
M
KF
T
EGA
F
K
D
W
G
YQ
L
A
R
E
EFGGELIDGGPWLKVKNPNTGK
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VIKDVI
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D
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I
L
LR
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A
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Y
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A
C
M
NL
N
GD
YI
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AL
AA
Q
V
G
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AN
IG
D
E
C-
-
-
A
LFE
A
T
HG
T
AP
KY
AG
QDKV
NP
GS
I
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A
E
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M
G
--
-
-
-
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AA
DL
I
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GM
E
G
AI
NA
K
TV
T
Y
D
FE
R
LME
GA
K
LLK
C
S
E
F
GDAI
I
K
fig|656440.3.peg.1053
Escherichia coli TA206 (25-414/416)
E
N
PI
I
P
Y
I
E
GDGIG
V
D
V
T
P
AM
LKV
V
DAA
V
E
K
A
YKG
ERK
IS
WMEIYT
G
EKS
-
TQV
Y
GQ
D
VW
LP
AE
T
L
D
LIR
E
Y
RV
AI
K
G
-
--
---
-
----
P
L
TT
P
VG
G
G
IRSLNV
A
LRQE
L
DLY
I
C
LRPVR
Y
YQG
T
P
--
S
P
V
-
-
-
K
H
P
ELT
D
MVI
F
REN
S
E
D
IY
-
AGIE
WK
AD
S
A
-
D
A
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K--
-
F
L
R
E
EM
GVKKIRFPEHCGIGIKPCSEEGT
KR
L
V
R
A
A
I
E
Y
A
IA
N
D
R
DS
VT
L
VH
K
G
N
I
M
KF
T
EGA
F
K
D
W
G
YQ
L
A
R
E
EFGGELIDGGPWLKVKNPNTGK
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VIKDVI
A
D
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Q
I
L
LR
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A
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Y
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A
C
M
NL
N
GD
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SD
AL
AA
Q
V
G
G
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G
AN
IG
D
E
C-
-
-
A
LFE
A
T
HG
T
AP
KY
AG
QDKV
NP
GS
I
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A
E
MMLRH
M
G
--
-
-
-
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AA
DL
I
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GM
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G
AI
NA
K
TV
T
Y
D
FE
R
LME
GA
K
LLK
C
S
E
F
GDAI
I
K
fig|656444.3.peg.1787
Escherichia coli TA280 (25-414/416)
E
N
PI
I
P
Y
I
E
GDGIG
V
D
V
T
P
AM
LKV
V
DAA
V
E
K
A
YKG
ERK
IS
WMEIYT
G
EKS
-
TQV
Y
GQ
D
VW
LP
AE
T
L
D
LIR
E
Y
RV
AI
K
G
-
--
---
-
----
P
L
TT
P
VG
G
G
IRSLNV
A
LRQE
L
DLY
I
C
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Y
YQG
T
P
--
S
P
V
-
-
-
K
H
P
ELT
D
MVI
F
REN
S
E
D
IY
-
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WK
AD
S
A
-
D
A
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K--
-
F
L
R
E
EM
GVKKIRFPEHCGIGIKPCSEEGT
KR
L
V
R
A
A
I
E
Y
A
IA
N
D
R
DS
VT
L
VH
K
G
N
I
M
KF
T
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F
K
D
W
G
YQ
L
A
R
E
EFGGELIDGGPWLKVKNPNTGK
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VIKDVI
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I
L
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A
C
M
NL
N
GD
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AL
AA
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V
G
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IG
D
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C-
-
-
A
LFE
A
T
HG
T
AP
KY
AG
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NP
GS
I
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A
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M
G
--
-
-
-
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AA
DL
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GM
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G
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TV
T
Y
D
FE
R
LME
GA
K
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C
S
E
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I
K
fig|869729.3.peg.2481
Escherichia coli UM146 (25-414/416)
E
N
PI
I
P
Y
I
E
GDGIG
V
D
V
T
P
AM
LKV
V
DAA
V
E
K
A
YKG
ERK
IS
WMEIYT
G
EKS
-
TQV
Y
GQ
D
VW
LP
AE
T
L
D
LIR
E
Y
RV
AI
K
G
-
--
---
-
----
P
L
TT
P
VG
G
G
IRSLNV
A
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L
DLY
I
C
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Y
YQG
T
P
--
S
P
V
-
-
-
K
H
P
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D
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F
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S
E
D
IY
-
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WK
AD
S
A
-
D
A
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K--
-
F
L
R
E
EM
GVKKIRFPEHCGIGIKPCSEEGT
KR
L
V
R
A
A
I
E
Y
A
IA
N
D
R
DS
VT
L
VH
K
G
N
I
M
KF
T
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F
K
D
W
G
YQ
L
A
R
E
EFGGELIDGGPWLKVKNPNTGK
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VIKDVI
A
D
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I
L
LR
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A
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A
C
M
NL
N
GD
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AL
AA
Q
V
G
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AN
IG
D
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C-
-
-
A
LFE
A
T
HG
T
AP
KY
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NP
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A
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--
-
-
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AA
DL
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TV
T
Y
D
FE
R
LME
GA
K
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C
S
E
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I
K
fig|585056.7.peg.1585
Escherichia coli UMN026 (25-414/416)
E
N
PI
I
P
Y
I
E
GDGIG
V
D
V
T
P
AM
LKV
V
DAA
V
E
K
A
YKG
ERK
IS
WMEIYT
G
EKS
-
TQV
Y
GQ
D
VW
LP
AE
T
L
D
LIR
E
Y
RV
AI
K
G
-
--
---
-
----
P
L
TT
P
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G
G
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L
DLY
I
C
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Y
YQG
T
P
--
S
P
V
-
-
-
K
H
P
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D
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F
REN
S
E
D
IY
-
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WK
AD
S
A
-
D
A
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K--
-
F
L
R
E
EM
GVKKIRFPEHCGIGIKPCSEEGT
KR
L
V
R
A
A
I
E
Y
A
IA
N
D
R
DS
VT
L
VH
K
G
N
I
M
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T
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F
K
D
W
G
YQ
L
A
R
E
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D
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I
L
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A
C
M
NL
N
GD
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SD
AL
AA
Q
V
G
G
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G
AN
IG
D
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C-
-
-
A
LFE
A
T
HG
T
AP
KY
AG
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NP
GS
I
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A
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M
G
--
-
-
-
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AA
DL
I
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GM
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G
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T
Y
D
FE
R
LME
GA
K
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C
S
E
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K
fig|364106.7.peg.1341
Escherichia coli UTI89 (25-414/416)
E
N
PI
I
P
Y
I
E
GDGIG
V
D
V
T
P
AM
LKV
V
DAA
V
E
K
A
YKG
ERK
IS
WMEIYT
G
EKS
-
TQV
Y
GQ
D
VW
LP
AE
T
L
D
LIR
E
Y
RV
AI
K
G
-
--
---
-
----
P
L
TT
P
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G
G
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A
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L
DLY
I
C
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Y
YQG
T
P
--
S
P
V
-
-
-
K
H
P
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D
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F
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S
E
D
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-
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WK
AD
S
A
-
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A
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K--
-
F
L
R
E
EM
GVKKIRFPEHCGIGIKPCSEEGT
KR
L
V
R
A
A
I
E
Y
A
IA
N
D
R
DS
VT
L
VH
K
G
N
I
M
KF
T
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F
K
D
W
G
YQ
L
A
R
E
EFGGELIDGGPWLKVKNPNTGK
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VIKDVI
A
D
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Q
I
L
LR
P
A
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Y
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A
C
M
NL
N
GD
YI
SD
AL
AA
Q
V
G
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G
AN
IG
D
E
C-
-
-
A
LFE
A
T
HG
T
AP
KY
AG
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NP
GS
I
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A
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MMLRH
M
G
--
-
-
-
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AA
DL
I
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GM
E
G
AI
NA
K
TV
T
Y
D
FE
R
LME
GA
K
LLK
C
S
E
F
GDAI
I
K
fig|364106.8.peg.1339
Escherichia coli UTI89 (25-414/416)
E
N
PI
I
P
Y
I
E
GDGIG
V
D
V
T
P
AM
LKV
V
DAA
V
E
K
A
YKG
ERK
IS
WMEIYT
G
EKS
-
TQV
Y
GQ
D
VW
LP
AE
T
L
D
LIR
E
Y
RV
AI
K
G
-
--
---
-
----
P
L
TT
P
VG
G
G
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A
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L
DLY
I
C
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Y
YQG
T
P
--
S
P
V
-
-
-
K
H
P
ELT
D
MVI
F
REN
S
E
D
IY
-
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WK
AD
S
A
-
D
A
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K--
-
F
L
R
E
EM
GVKKIRFPEHCGIGIKPCSEEGT
KR
L
V
R
A
A
I
E
Y
A
IA
N
D
R
DS
VT
L
VH
K
G
N
I
M
KF
T
EGA
F
K
D
W
G
YQ
L
A
R
E
EFGGELIDGGPWLKVKNPNTGK
EI
VIKDVI
A
D
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Q
I
L
LR
P
A
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Y
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A
C
M
NL
N
GD
YI
SD
AL
AA
Q
V
G
G
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G
AN
IG
D
E
C-
-
-
A
LFE
A
T
HG
T
AP
KY
AG
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NP
GS
I
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A
E
MMLRH
M
G
--
-
-
-
WTE
AA
DL
I
VK
GM
E
G
AI
NA
K
TV
T
Y
D
FE
R
LME
GA
K
LLK
C
S
E
F
GDAI
I
K
fig|566546.3.peg.357
Escherichia coli W (25-414/416)
E
N
PI
I
P
Y
I
E
GDGIG
V
D
V
T
P
AM
LKV
V
DAA
V
E
K
A
YKG
ERK
IS
WMEIYT
G
EKS
-
TQV
Y
GQ
D
VW
LP
AE
T
L
D
LIR
E
Y
RV
AI
K
G
-
--
---
-
----
P
L
TT
P
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G
G
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A
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L
DLY
I
C
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Y
YQG
T
P
--
S
P
V
-
-
-
K
H
P
ELT
D
MVI
F
REN
S
E
D
IY
-
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WK
AD
S
A
-
D
A
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K--
-
F
L
R
E
EM
GVKKIRFPEHCGIGIKPCSEEGT
KR
L
V
R
A
A
I
E
Y
A
IA
N
D
R
DS
VT
L
VH
K
G
N
I
M
KF
T
EGA
F
K
D
W
G
YQ
L
A
R
E
EFGGELIDGGPWLKVKNPNTGK
EI
VIKDVI
A
D
AFLQ
Q
I
L
LR
P
A
E
Y
DVI
A
C
M
NL
N
GD
YI
SD
AL
AA
Q
V
G
G
IGIAP
G
AN
IG
D
E
C-
-
-
A
LFE
A
T
HG
T
AP
KY
AG
QDKV
NP
GS
I
ILS
A
E
MMLRH
M
G
--
-
-
-
WTE
AA
DL
I
VK
GM
E
G
AI
NA
K
TV
T
Y
D
FE
R
LME
GA
K
LLK
C
S
E
F
GDAI
I
K
fig|566546.4.peg.1240
Escherichia coli W (25-414/416)
E
N
PI
I
P
Y
I
E
GDGIG
V
D
V
T
P
AM
LKV
V
DAA
V
E
K
A
YKG
ERK
IS
WMEIYT
G
EKS
-
TQV
Y
GQ
D
VW
LP
AE
T
L
D
LIR
E
Y
RV
AI
K
G
-
--
---
-
----
P
L
TT
P
VG
G
G
IRSLNV
A
LRQE
L
DLY
I
C
LRPVR
Y
YQG
T
P
--
S
P
V
-
-
-
K
H
P
ELT
D
MVI
F
REN
S
E
D
IY
-
AGIE
WK
AD
S
A
-
D
A
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K--
-
F
L
R
E
EM
GVKKIRFPEHCGIGIKPCSEEGT
KR
L
V
R
A
A
I
E
Y
A
IA
N
D
R
DS
VT
L
VH
K
G
N
I
M
KF
T
EGA
F
K
D
W
G
YQ
L
A
R
E
EFGGELIDGGPWLKVKNPNTGK
EI
VIKDVI
A
D
AFLQ
Q
I
L
LR
P
A
E
Y
DVI
A
C
M
NL
N
GD
YI
SD
AL
AA
Q
V
G
G
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G
AN
IG
D
E
C-
-
-
A
LFE
A
T
HG
T
AP
KY
AG
QDKV
NP
GS
I
ILS
A
E
MMLRH
M
G
--
-
-
-
WTE
AA
DL
I
VK
GM
E
G
AI
NA
K
TV
T
Y
D
FE
R
LME
GA
K
LLK
C
S
E
F
GDAI
I
K
fig|562.376.peg.3346
Escherichia coli WV_060327 (25-414/416)
E
N
PI
I
P
Y
I
E
GDGIG
V
D
V
T
P
AM
LKV
V
DAA
V
E
K
A
YKG
ERK
IS
WMEIYT
G
EKS
-
TQV
Y
GQ
D
VW
LP
AE
T
L
D
LIR
E
Y
RV
AI
K
G
-
--
---
-
----
P
L
TT
P
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G
G
IRSLNV
A
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L
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Y
YQG
T
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--
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-
-
-
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H
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S
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D
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WK
AD
S
A
-
D
A
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K--
-
F
L
R
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EM
GVKKIRFPEHCGIGIKPCSEEGT
KR
L
V
R
A
A
I
E
Y
A
IA
N
D
R
DS
VT
L
VH
K
G
N
I
M
KF
T
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F
K
D
W
G
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L
A
R
E
EFGGELIDGGPWLKVKNPNTGK
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A
D
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I
L
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A
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A
C
M
NL
N
GD
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SD
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AA
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V
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AN
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C-
-
-
A
LFE
A
T
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T
AP
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GS
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G
--
-
-
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AA
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TV
T
Y
D
FE
R
LME
GA
K
LLK
C
S
E
F
GDAI
I
K
fig|536056.3.peg.2643
Escherichia coli DH1 (25-412/416)
E
N
PI
I
P
Y
I
E
GDGIG
V
D
V
T
P
AM
LKV
V
DAA
V
E
K
A
YKG
ERK
IS
WMEIYT
G
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-
TQV
Y
GQ
D
VW
LP
AE
T
L
D
LIR
E
Y
RV
AI
K
G
-
--
---
-
----
P
L
TT
P
VG
G
G
IRSLNV
A
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L
DLY
I
C
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Y
YQG
T
P
--
S
P
V
-
-
-
K
H
P
ELT
D
MVI
F
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S
E
D
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-
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WK
AD
S
A
-
D
A
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K--
-
F
L
R
E
EM
GVKKIRFPEHCGIGIKPCSEEGT
KR
L
V
R
A
A
I
E
Y
A
IA
N
D
R
DS
VT
L
VH
K
G
N
I
M
KF
T
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F
K
D
W
G
YQ
L
A
R
E
EFGGELIDGGPWLKVKNPNTGK
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VIKDVI
A
D
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I
L
LR
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A
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Y
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A
C
M
NL
N
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V
G
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D
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C-
-
-
A
LFE
A
T
HG
T
AP
KY
AG
QDKV
NP
GS
I
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A
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MMLRH
M
G
--
-
-
-
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AA
DL
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GM
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G
AI
NA
K
TV
T
Y
D
FE
R
LM
D
GA
K
LLK
C
S
E
F
GDAI
fig|83333.1.peg.1121
Escherichia coli K12 (25-412/416)
E
N
PI
I
P
Y
I
E
GDGIG
V
D
V
T
P
AM
LKV
V
DAA
V
E
K
A
YKG
ERK
IS
WMEIYT
G
EKS
-
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Y
GQ
D
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AE
T
L
D
LIR
E
Y
RV
AI
K
G
-
--
---
-
----
P
L
TT
P
VG
G
G
IRSLNV
A
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L
DLY
I
C
LRPVR
Y
YQG
T
P
--
S
P
V
-
-
-
K
H
P
ELT
D
MVI
F
REN
S
E
D
IY
-
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WK
AD
S
A
-
D
A
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K--
-
F
L
R
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EM
GVKKIRFPEHCGIGIKPCSEEGT
KR
L
V
R
A
A
I
E
Y
A
IA
N
D
R
DS
VT
L
VH
K
G
N
I
M
KF
T
EGA
F
K
D
W
G
YQ
L
A
R
E
EFGGELIDGGPWLKVKNPNTGK
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D
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I
L
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A
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A
C
M
NL
N
GD
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AA
Q
V
G
G
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AN
IG
D
E
C-
-
-
A
LFE
A
T
HG
T
AP
KY
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NP
GS
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A
E
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G
--
-
-
-
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AA
DL
I
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GM
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G
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NA
K
TV
T
Y
D
FE
R
LM
D
GA
K
LLK
C
S
E
F
GDAI
fig|316407.3.peg.1098
Escherichia coli W3110 (25-412/416)
E
N
PI
I
P
Y
I
E
GDGIG
V
D
V
T
P
AM
LKV
V
DAA
V
E
K
A
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ERK
IS
WMEIYT
G
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-
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Y
GQ
D
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LP
AE
T
L
D
LIR
E
Y
RV
AI
K
G
-
--
---
-
----
P
L
TT
P
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G
G
IRSLNV
A
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L
DLY
I
C
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Y
YQG
T
P
--
S
P
V
-
-
-
K
H
P
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D
MVI
F
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S
E
D
IY
-
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WK
AD
S
A
-
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K--
-
F
L
R
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EM
GVKKIRFPEHCGIGIKPCSEEGT
KR
L
V
R
A
A
I
E
Y
A
IA
N
D
R
DS
VT
L
VH
K
G
N
I
M
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T
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F
K
D
W
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YQ
L
A
R
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D
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I
L
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A
C
M
NL
N
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AA
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V
G
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C-
-
-
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LFE
A
T
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T
AP
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A
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M
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--
-
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AA
DL
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GM
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G
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TV
T
Y
D
FE
R
LM
D
GA
K
LLK
C
S
E
F
GDAI
fig|511145.12.peg.1183
Escherichia coli str. K-12 substr. MG1655 (25-412/416)
E
N
PI
I
P
Y
I
E
GDGIG
V
D
V
T
P
AM
LKV
V
DAA
V
E
K
A
YKG
ERK
IS
WMEIYT
G
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-
TQV
Y
GQ
D
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LP
AE
T
L
D
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E
Y
RV
AI
K
G
-
--
---
-
----
P
L
TT
P
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G
G
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A
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L
DLY
I
C
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Y
YQG
T
P
--
S
P
V
-
-
-
K
H
P
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D
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F
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S
E
D
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-
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WK
AD
S
A
-
D
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K--
-
F
L
R
E
EM
GVKKIRFPEHCGIGIKPCSEEGT
KR
L
V
R
A
A
I
E
Y
A
IA
N
D
R
DS
VT
L
VH
K
G
N
I
M
KF
T
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F
K
D
W
G
YQ
L
A
R
E
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D
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I
L
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P
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A
C
M
NL
N
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AA
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V
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D
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C-
-
-
A
LFE
A
T
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T
AP
KY
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NP
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A
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M
G
--
-
-
-
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AA
DL
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GM
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G
AI
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TV
T
Y
D
FE
R
LM
D
GA
K
LLK
C
S
E
F
GDAI
fig|511145.6.peg.1174
Escherichia coli str. K-12 substr. MG1655 (25-412/416)
E
N
PI
I
P
Y
I
E
GDGIG
V
D
V
T
P
AM
LKV
V
DAA
V
E
K
A
YKG
ERK
IS
WMEIYT
G
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-
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Y
GQ
D
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LP
AE
T
L
D
LIR
E
Y
RV
AI
K
G
-
--
---
-
----
P
L
TT
P
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G
G
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A
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L
DLY
I
C
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Y
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P
--
S
P
V
-
-
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H
P
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D
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F
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S
E
D
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WK
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S
A
-
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-
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L
R
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GVKKIRFPEHCGIGIKPCSEEGT
KR
L
V
R
A
A
I
E
Y
A
IA
N
D
R
DS
VT
L
VH
K
G
N
I
M
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T
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F
K
D
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L
A
R
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I
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A
C
M
NL
N
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G
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C-
-
-
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A
T
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T
AP
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A
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--
-
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TV
T
Y
D
FE
R
LM
D
GA
K
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C
S
E
F
GDAI
fig|749545.3.peg.858
Escherichia coli MS 182-1 (25-414/416)
E
N
PI
I
P
Y
I
E
GDGIG
V
D
V
T
P
AM
LKV
V
DAA
V
E
K
A
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ERK
IS
WMEIYT
G
EKS
-
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Y
GQ
D
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LP
AE
T
L
D
LIR
E
Y
RV
AI
K
G
-
--
---
-
----
P
L
TT
P
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G
G
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L
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I
C
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Y
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T
P
--
S
P
V
-
-
-
K
H
P
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D
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F
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S
E
D
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-
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WK
AD
S
A
-
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-
F
L
R
E
EM
GVKKIRFPEHCGIGIKPCSEEGT
KR
L
V
R
A
A
I
E
Y
A
IA
N
D
R
DS
VT
L
VH
K
G
N
I
M
KF
T
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F
K
D
W
G
YQ
L
A
R
E
EFGGELIDGGPWLKVKNPNTGK
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A
D
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Q
I
L
LR
P
A
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Y
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A
C
M
NL
N
GD
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SD
AL
AA
Q
V
G
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AN
IG
D
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C-
-
-
A
LFE
A
T
HG
T
AP
KY
AG
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NP
GS
I
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A
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MMLRH
M
G
--
-
-
-
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AA
DL
I
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GM
E
G
AI
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K
TV
T
Y
D
FE
R
LME
GA
K
LLK
C
S
E
F
GDAI
I
K
fig|749532.3.peg.3239
Escherichia coli MS 78-1 (25-414/416)
E
N
PI
I
P
Y
I
E
GDGIG
V
D
V
T
P
AM
LKV
V
DAA
V
E
K
A
YKG
ERK
IS
WMEIYT
G
EKS
-
TQV
Y
GQ
D
VW
LP
AE
T
L
D
LIR
E
Y
RV
AI
K
G
-
--
---
-
----
P
L
TT
P
VG
G
G
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A
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L
DLY
I
C
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Y
YQG
T
P
--
S
P
V
-
-
-
K
H
P
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D
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F
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S
E
D
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-
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WK
AD
S
A
-
D
A
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K--
-
F
L
R
E
EM
GVKKIRFPEHCGIGIKPCSEEGT
KR
L
V
R
A
A
I
E
Y
A
IA
N
D
R
DS
VT
L
VH
K
G
N
I
M
KF
T
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F
K
D
W
G
YQ
L
A
R
E
EFGGELIDGGPWLKVKNPNTGK
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A
D
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Q
I
L
LR
P
A
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Y
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A
C
M
NL
N
GD
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SD
AL
AA
Q
V
G
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G
AN
IG
D
E
C-
-
-
A
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A
T
HG
T
AP
KY
AG
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NP
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I
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A
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M
G
--
-
-
-
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AA
DL
I
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GM
E
G
AI
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K
TV
T
Y
D
FE
R
LME
GA
K
LLK
C
S
E
F
GDAI
I
K
fig|749538.3.peg.2753
Escherichia coli MS 116-1 (25-412/416)
E
N
PI
I
P
Y
I
E
GDGIG
V
D
V
T
P
AM
LKV
V
DAA
V
E
K
A
YKG
ERK
IS
WMEIYT
G
EKS
-
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Y
GQ
D
VW
LP
AE
T
L
D
LIR
E
Y
RV
AI
K
G
-
--
---
-
----
P
L
TT
P
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G
G
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A
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L
DLY
I
C
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Y
YQG
T
P
--
S
P
V
-
-
-
K
H
P
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D
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F
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S
E
D
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-
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WK
AD
S
A
-
D
A
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K--
-
F
L
R
E
EM
GVKKIRFPEHCGIGIKPCSEEGT
KR
L
V
R
A
A
I
E
Y
A
IA
N
D
R
DS
VT
L
VH
K
G
N
I
M
KF
T
EGA
F
K
D
W
G
YQ
L
A
R
E
EFGGELIDGGPWLKVKNPNTGK
EI
VIKDVI
A
D
AFLQ
Q
I
L
LR
P
A
E
Y
DVI
A
C
M
NL
N
GD
YI
SD
AL
AA
Q
V
G
G
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G
AN
IG
D
E
C-
-
-
A
LFE
A
T
HG
T
AP
KY
AG
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NP
GS
I
ILS
A
E
MMLRH
M
Q
--
-
-
-
WFE
AA
DL
I
VK
GM
E
G
AI
AA
K
TV
T
Y
D
FE
R
LME
GA
K
LLK
C
S
E
F
GDAI
fig|344610.3.peg.4367
Escherichia coli 53638 (25-412/416)
E
N
PI
I
P
Y
I
E
GDGIG
V
D
V
T
P
AM
LKV
V
DAA
V
E
K
A
YKG
ERK
IS
WMEIYT
G
EKS
-
TQV
Y
GQ
D
VW
LP
AE
T
L
D
LIR
E
Y
RV
AI
K
G
-
--
---
-
----
P
L
TT
P
VG
G
G
IRSLNV
A
LRQE
L
DLY
I
C
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Y
YQG
T
P
--
S
P
V
-
-
-
K
H
P
ELT
D
MVI
F
REN
S
E
D
IY
-
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WK
AD
S
A
-
D
A
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K--
-
F
L
R
E
EM
GVKKIRFPEHCGIGIKPCSEEGT
KR
L
V
R
A
A
I
E
Y
A
IA
N
D
R
DS
VT
L
VH
K
G
N
I
M
KF
T
EGA
F
K
D
W
G
YQ
L
A
R
E
EFGGELIDGGPWLKVKNPNTGK
EI
VIKDVI
A
D
AFLQ
Q
I
L
LR
P
A
E
Y
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A
C
M
NL
N
GD
YI
SD
AL
AA
Q
V
G
G
IGIAP
G
AN
IG
D
E
C-
-
-
A
LFE
A
T
HG
T
AP
KY
AG
QDKV
NP
GS
I
ILS
A
E
MMLRH
M
G
--
-
-
-
WTE
AA
DL
I
VK
GM
E
G
AI
NA
K
TV
T
Y
D
FE
R
LME
GA
K
LLK
C
S
E
F
G
E
AI
fig|344610.7.peg.4823
Escherichia coli 53638 (25-412/416)
E
N
PI
I
P
Y
I
E
GDGIG
V
D
V
T
P
AM
LKV
V
DAA
V
E
K
A
YKG
ERK
IS
WMEIYT
G
EKS
-
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Y
GQ
D
VW
LP
AE
T
L
D
LIR
E
Y
RV
AI
K
G
-
--
---
-
----
P
L
TT
P
VG
G
G
IRSLNV
A
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L
DLY
I
C
LRPVR
Y
YQG
T
P
--
S
P
V
-
-
-
K
H
P
ELT
D
MVI
F
REN
S
E
D
IY
-
AGIE
WK
AD
S
A
-
D
A
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K--
-
F
L
R
E
EM
GVKKIRFPEHCGIGIKPCSEEGT
KR
L
V
R
A
A
I
E
Y
A
IA
N
D
R
DS
VT
L
VH
K
G
N
I
M
KF
T
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F
K
D
W
G
YQ
L
A
R
E
EFGGELIDGGPWLKVKNPNTGK
EI
VIKDVI
A
D
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Q
I
L
LR
P
A
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A
C
M
NL
N
GD
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V
G
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AN
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C-
-
-
A
LFE
A
T
HG
T
AP
KY
AG
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M
G
--
-
-
-
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AA
DL
I
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GM
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G
AI
NA
K
TV
T
Y
D
FE
R
LME
GA
K
LLK
C
S
E
F
G
E
AI
fig|481805.3.peg.2650
Escherichia coli ATCC 8739 (25-412/416)
E
N
PI
I
P
Y
I
E
GDGIG
V
D
V
T
P
AM
LKV
V
DAA
V
E
K
A
YKG
ERK
IS
WMEIYT
G
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-
TQV
Y
GQ
D
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LP
AE
T
L
D
LIR
E
Y
RV
AI
K
G
-
--
---
-
----
P
L
TT
P
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G
G
IRSLNV
A
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L
DLY
I
C
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Y
YQG
T
P
--
S
P
V
-
-
-
K
H
P
ELT
D
MVI
F
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S
E
D
IY
-
AGIE
WK
AD
S
A
-
D
A
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K--
-
F
L
R
E
EM
GVKKIRFPEHCGIGIKPCSEEGT
KR
L
V
R
A
A
I
E
Y
A
IA
N
D
R
DS
VT
L
VH
K
G
N
I
M
KF
T
EGA
F
K
D
W
G
YQ
L
A
R
E
EFGGELIDGGPWLKVKNPNTGK
EI
VIKDVI
A
D
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I
L
LR
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A
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A
C
M
NL
N
GD
YI
SD
AL
AA
Q
V
G
G
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G
AN
IG
D
E
C-
-
-
A
LFE
A
T
HG
T
AP
KY
AG
QDKV
NP
GS
I
ILS
A
E
MMLRH
M
G
--
-
-
-
WTE
AA
DL
I
VK
GM
E
G
AI
NA
K
TV
T
Y
D
FE
R
LME
GA
K
LLK
C
S
E
F
G
E
AI
fig|481805.6.peg.2638
Escherichia coli ATCC 8739 (25-412/416)
E
N
PI
I
P
Y
I
E
GDGIG
V
D
V
T
P
AM
LKV
V
DAA
V
E
K
A
YKG
ERK
IS
WMEIYT
G
EKS
-
TQV
Y
GQ
D
VW
LP
AE
T
L
D
LIR
E
Y
RV
AI
K
G
-
--
---
-
----
P
L
TT
P
VG
G
G
IRSLNV
A
LRQE
L
DLY
I
C
LRPVR
Y
YQG
T
P
--
S
P
V
-
-
-
K
H
P
ELT
D
MVI
F
REN
S
E
D
IY
-
AGIE
WK
AD
S
A
-
D
A
EKVI
K--
-
F
L
R
E
EM
GVKKIRFPEHCGIGIKPCSEEGT
KR
L
V
R
A
A
I
E
Y
A
IA
N
D
R
DS
VT
L
VH
K
G
N
I
M
KF
T
EGA
F
K
D
W
G
YQ
L
A
R
E
EFGGELIDGGPWLKVKNPNTGK
EI
VIKDVI
A
D
AFLQ
Q
I
L
LR
P
A
E
Y
DVI
A
C
M
NL
N
GD
YI
SD
AL
AA
Q
V
G
G
IGIAP
G
AN
IG
D
E
C-
-
-
A
LFE
A
T
HG
T
AP
KY
AG
QDKV
NP
GS
I
ILS
A
E
MMLRH
M
G
--
-
-
-
WTE
AA
DL
I
VK
GM
E
G
AI
NA
K
TV
T
Y
D
FE
R
LME
GA
K
LLK
C
S
E
F
G
E
AI
fig|595496.3.peg.1083
Escherichia coli BW2952 (25-412/416)
E
N
PI
I
P
Y
I
E
GDGIG
V
D
V
T
P
AM
LKV
V
DAA
V
E
K
A
YKG
ERK
IS
WMEIYT
G
EKS
-
TQV
Y
GQ
D
VW
LP
AE
T
L
D
LIR
E
Y
RV
AI
K
G
-
--
---
-
----
P
L
TT
P
VG
G
G
IRSLNV
A
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L
DLY
I
C
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Y
YQG
T
P
--
S
P
V
-
-
-
K
H
P
ELT
D
MVI
F
REN
S
E
D
IY
-
AGIE
WK
AD
S
A
-
D
A
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K--
-
F
L
R
E
EM
GVKKIRFPEHCGIGIKPCSEEGT
KR
L
V
R
A
A
I
E
Y
A
IA
N
D
R
DS
VT
L
VH
K
G
N
I
M
KF
T
EGA
F
K
D
W
G
YQ
L
A
R
E
EFGGELIDGGPWLKVKNPNTGK
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VIKDVI
A
D
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I
L
LR
P
A
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Y
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A
C
M
NL
N
GD
YI
SD
AL
AA
Q
V
G
G
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IG
D
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C-
-
-
A
LFE
A
T
HG
T
AP
KY
AG
QDKV
NP
GS
I
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A
E
MMLRH
M
G
--
-
-
-
WTE
AA
DL
I
VK
GM
E
G
AI
NA
K
TV
T
Y
D
FE
R
LME
GA
K
LLK
C
S
E
F
G
E
AI
fig|316401.4.peg.1455
Escherichia coli ETEC H10407 (25-412/416)
E
N
PI
I
P
Y
I
E
GDGIG
V
D
V
T
P
AM
LKV
V
DAA
V
E
K
A
YKG
ERK
IS
WMEIYT
G
EKS
-
TQV
Y
GQ
D
VW
LP
AE
T
L
D
LIR
E
Y
RV
AI
K
G
-
--
---
-
----
P
L
TT
P
VG
G
G
IRSLNV
A
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L
DLY
I
C
LRPVR
Y
YQG
T
P
--
S
P
V
-
-
-
K
H
P
ELT
D
MVI
F
REN
S
E
D
IY
-
AGIE
WK
AD
S
A
-
D
A
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K--
-
F
L
R
E
EM
GVKKIRFPEHCGIGIKPCSEEGT
KR
L
V
R
A
A
I
E
Y
A
IA
N
D
R
DS
VT
L
VH
K
G
N
I
M
KF
T
EGA
F
K
D
W
G
YQ
L
A
R
E
EFGGELIDGGPWLKVKNPNTGK
EI
VIKDVI
A
D
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Q
I
L
LR
P
A
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Y
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A
C
M
NL
N
GD
YI
SD
AL
AA
Q
V
G
G
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G
AN
IG
D
E
C-
-
-
A
LFE
A
T
HG
T
AP
KY
AG
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NP
GS
I
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A
E
MMLRH
M
G
--
-
-
-
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AA
DL
I
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GM
E
G
AI
NA
K
TV
T
Y
D
FE
R
LME
GA
K
LLK
C
S
E
F
G
E
AI
fig|656414.3.peg.1383
Escherichia coli H736 (25-412/416)
E
N
PI
I
P
Y
I
E
GDGIG
V
D
V
T
P
AM
LKV
V
DAA
V
E
K
A
YKG
ERK
IS
WMEIYT
G
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-
TQV
Y
GQ
D
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LP
AE
T
L
D
LIR
E
Y
RV
AI
K
G
-
--
---
-
----
P
L
TT
P
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G
G
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L
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I
C
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Y
YQG
T
P
--
S
P
V
-
-
-
K
H
P
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D
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F
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S
E
D
IY
-
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WK
AD
S
A
-
D
A
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K--
-
F
L
R
E
EM
GVKKIRFPEHCGIGIKPCSEEGT
KR
L
V
R
A
A
I
E
Y
A
IA
N
D
R
DS
VT
L
VH
K
G
N
I
M
KF
T
EGA
F
K
D
W
G
YQ
L
A
R
E
EFGGELIDGGPWLKVKNPNTGK
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VIKDVI
A
D
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Q
I
L
LR
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A
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Y
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A
C
M
NL
N
GD
YI
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AL
AA
Q
V
G
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AN
IG
D
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C-
-
-
A
LFE
A
T
HG
T
AP
KY
AG
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NP
GS
I
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A
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MMLRH
M
G
--
-
-
-
WTE
AA
DL
I
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GM
E
G
AI
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K
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T
Y
D
FE
R
LME
GA
K
LLK
C
S
E
F
G
E
AI
fig|331112.3.peg.1174
Escherichia coli HS (25-412/416)
E
N
PI
I
P
Y
I
E
GDGIG
V
D
V
T
P
AM
LKV
V
DAA
V
E
K
A
YKG
ERK
IS
WMEIYT
G
EKS
-
TQV
Y
GQ
D
VW
LP
AE
T
L
D
LIR
E
Y
RV
AI
K
G
-
--
---
-
----
P
L
TT
P
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G
G
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A
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L
DLY
I
C
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Y
YQG
T
P
--
S
P
V
-
-
-
K
H
P
ELT
D
MVI
F
REN
S
E
D
IY
-
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WK
AD
S
A
-
D
A
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K--
-
F
L
R
E
EM
GVKKIRFPEHCGIGIKPCSEEGT
KR
L
V
R
A
A
I
E
Y
A
IA
N
D
R
DS
VT
L
VH
K
G
N
I
M
KF
T
EGA
F
K
D
W
G
YQ
L
A
R
E
EFGGELIDGGPWLKVKNPNTGK
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VIKDVI
A
D
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Q
I
L
LR
P
A
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Y
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A
C
M
NL
N
GD
YI
SD
AL
AA
Q
V
G
G
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G
AN
IG
D
E
C-
-
-
A
LFE
A
T
HG
T
AP
KY
AG
QDKV
NP
GS
I
ILS
A
E
MMLRH
M
G
--
-
-
-
WTE
AA
DL
I
VK
GM
E
G
AI
NA
K
TV
T
Y
D
FE
R
LME
GA
K
LLK
C
S
E
F
G
E
AI
fig|331112.6.peg.1225
Escherichia coli HS (25-412/416)
E
N
PI
I
P
Y
I
E
GDGIG
V
D
V
T
P
AM
LKV
V
DAA
V
E
K
A
YKG
ERK
IS
WMEIYT
G
EKS
-
TQV
Y
GQ
D
VW
LP
AE
T
L
D
LIR
E
Y
RV
AI
K
G
-
--
---
-
----
P
L
TT
P
VG
G
G
IRSLNV
A
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L
DLY
I
C
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Y
YQG
T
P
--
S
P
V
-
-
-
K
H
P
ELT
D
MVI
F
REN
S
E
D
IY
-
AGIE
WK
AD
S
A
-
D
A
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K--
-
F
L
R
E
EM
GVKKIRFPEHCGIGIKPCSEEGT
KR
L
V
R
A
A
I
E
Y
A
IA
N
D
R
DS
VT
L
VH
K
G
N
I
M
KF
T
EGA
F
K
D
W
G
YQ
L
A
R
E
EFGGELIDGGPWLKVKNPNTGK
EI
VIKDVI
A
D
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Q
I
L
LR
P
A
E
Y
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A
C
M
NL
N
GD
YI
SD
AL
AA
Q
V
G
G
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G
AN
IG
D
E
C-
-
-
A
LFE
A
T
HG
T
AP
KY
AG
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NP
GS
I
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A
E
MMLRH
M
G
--
-
-
-
WTE
AA
DL
I
VK
GM
E
G
AI
NA
K
TV
T
Y
D
FE
R
LME
GA
K
LLK
C
S
E
F
G
E
AI
fig|749537.3.peg.1635
Escherichia coli MS 115-1 (25-412/416)
E
N
PI
I
P
Y
I
E
GDGIG
V
D
V
T
P
AM
LKV
V
DAA
V
E
K
A
YKG
ERK
IS
WMEIYT
G
EKS
-
TQV
Y
GQ
D
VW
LP
AE
T
L
D
LIR
E
Y
RV
AI
K
G
-
--
---
-
----
P
L
TT
P
VG
G
G
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A
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L
DLY
I
C
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Y
YQG
T
P
--
S
P
V
-
-
-
K
H
P
ELT
D
MVI
F
REN
S
E
D
IY
-
AGIE
WK
AD
S
A
-
D
A
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K--
-
F
L
R
E
EM
GVKKIRFPEHCGIGIKPCSEEGT
KR
L
V
R
A
A
I
E
Y
A
IA
N
D
R
DS
VT
L
VH
K
G
N
I
M
KF
T
EGA
F
K
D
W
G
YQ
L
A
R
E
EFGGELIDGGPWLKVKNPNTGK
EI
VIKDVI
A
D
AFLQ
Q
I
L
LR
P
A
E
Y
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A
C
M
NL
N
GD
YI
SD
AL
AA
Q
V
G
G
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G
AN
IG
D
E
C-
-
-
A
LFE
A
T
HG
T
AP
KY
AG
QDKV
NP
GS
I
ILS
A
E
MMLRH
M
G
--
-
-
-
WTE
AA
DL
I
VK
GM
E
G
AI
NA
K
TV
T
Y
D
FE
R
LME
GA
K
LLK
C
S
E
F
G
E
AI
fig|749540.3.peg.1165
Escherichia coli MS 146-1 (25-412/416)
E
N
PI
I
P
Y
I
E
GDGIG
V
D
V
T
P
AM
LKV
V
DAA
V
E
K
A
YKG
ERK
IS
WMEIYT
G
EKS
-
TQV
Y
GQ
D
VW
LP
AE
T
L
D
LIR
E
Y
RV
AI
K
G
-
--
---
-
----
P
L
TT
P
VG
G
G
IRSLNV
A
LRQE
L
DLY
I
C
LRPVR
Y
YQG
T
P
--
S
P
V
-
-
-
K
H
P
ELT
D
MVI
F
REN
S
E
D
IY
-
AGIE
WK
AD
S
A
-
D
A
EKVI
K--
-
F
L
R
E
EM
GVKKIRFPEHCGIGIKPCSEEGT
KR
L
V
R
A
A
I
E
Y
A
IA
N
D
R
DS
VT
L
VH
K
G
N
I
M
KF
T
EGA
F
K
D
W
G
YQ
L
A
R
E
EFGGELIDGGPWLKVKNPNTGK
EI
VIKDVI
A
D
AFLQ
Q
I
L
LR
P
A
E
Y
DVI
A
C
M
NL
N
GD
YI
SD
AL
AA
Q
V
G
G
IGIAP
G
AN
IG
D
E
C-
-
-
A
LFE
A
T
HG
T
AP
KY
AG
QDKV
NP
GS
I
ILS
A
E
MMLRH
M
G
--
-
-
-
WTE
AA
DL
I
VK
GM
E
G
AI
NA
K
TV
T
Y
D
FE
R
LME
GA
K
LLK
C
S
E
F
G
E
AI
fig|749544.3.peg.1347
Escherichia coli MS 175-1 (25-412/416)
E
N
PI
I
P
Y
I
E
GDGIG
V
D
V
T
P
AM
LKV
V
DAA
V
E
K
A
YKG
ERK
IS
WMEIYT
G
EKS
-
TQV
Y
GQ
D
VW
LP
AE
T
L
D
LIR
E
Y
RV
AI
K
G
-
--
---
-
----
P
L
TT
P
VG
G
G
IRSLNV
A
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L
DLY
I
C
LRPVR
Y
YQG
T
P
--
S
P
V
-
-
-
K
H
P
ELT
D
MVI
F
REN
S
E
D
IY
-
AGIE
WK
AD
S
A
-
D
A
EKVI
K--
-
F
L
R
E
EM
GVKKIRFPEHCGIGIKPCSEEGT
KR
L
V
R
A
A
I
E
Y
A
IA
N
D
R
DS
VT
L
VH
K
G
N
I
M
KF
T
EGA
F
K
D
W
G
YQ
L
A
R
E
EFGGELIDGGPWLKVKNPNTGK
EI
VIKDVI
A
D
AFLQ
Q
I
L
LR
P
A
E
Y
DVI
A
C
M
NL
N
GD
YI
SD
AL
AA
Q
V
G
G
IGIAP
G
AN
IG
D
E
C-
-
-
A
LFE
A
T
HG
T
AP
KY
AG
QDKV
NP
GS
I
ILS
A
E
MMLRH
M
G
--
-
-
-
WTE
AA
DL
I
VK
GM
E
G
AI
NA
K
TV
T
Y
D
FE
R
LME
GA
K
LLK
C
S
E
F
G
E
AI
fig|749548.3.peg.5012
Escherichia coli MS 196-1 (25-412/416)
E
N
PI
I
P
Y
I
E
GDGIG
V
D
V
T
P
AM
LKV
V
DAA
V
E
K
A
YKG
ERK
IS
WMEIYT
G
EKS
-
TQV
Y
GQ
D
VW
LP
AE
T
L
D
LIR
E
Y
RV
AI
K
G
-
--
---
-
----
P
L
TT
P
VG
G
G
IRSLNV
A
LRQE
L
DLY
I
C
LRPVR
Y
YQG
T
P
--
S
P
V
-
-
-
K
H
P
ELT
D
MVI
F
REN
S
E
D
IY
-
AGIE
WK
AD
S
A
-
D
A
EKVI
K--
-
F
L
R
E
EM
GVKKIRFPEHCGIGIKPCSEEGT
KR
L
V
R
A
A
I
E
Y
A
IA
N
D
R
DS
VT
L
VH
K
G
N
I
M
KF
T
EGA
F
K
D
W
G
YQ
L
A
R
E
EFGGELIDGGPWLKVKNPNTGK
EI
VIKDVI
A
D
AFLQ
Q
I
L
LR
P
A
E
Y
DVI
A
C
M
NL
N
GD
YI
SD
AL
AA
Q
V
G
G
IGIAP
G
AN
IG
D
E
C-
-
-
A
LFE
A
T
HG
T
AP
KY
AG
QDKV
NP
GS
I
ILS
A
E
MMLRH
M
G
--
-
-
-
WTE
AA
DL
I
VK
GM
E
G
AI
NA
K
TV
T
Y
D
FE
R
LME
GA
K
LLK
C
S
E
F
G
E
AI
fig|316385.5.peg.1215
Escherichia coli str. K-12 substr. DH10B (25-412/416)
E
N
PI
I
P
Y
I
E
GDGIG
V
D
V
T
P
AM
LKV
V
DAA
V
E
K
A
YKG
ERK
IS
WMEIYT
G
EKS
-
TQV
Y
GQ
D
VW
LP
AE
T
L
D
LIR
E
Y
RV
AI
K
G
-
--
---
-
----
P
L
TT
P
VG
G
G
IRSLNV
A
LRQE
L
DLY
I
C
LRPVR
Y
YQG
T
P
--
S
P
V
-
-
-
K
H
P
ELT
D
MVI
F
REN
S
E
D
IY
-
AGIE
WK
AD
S
A
-
D
A
EKVI
K--
-
F
L
R
E
EM
GVKKIRFPEHCGIGIKPCSEEGT
KR
L
V
R
A
A
I
E
Y
A
IA
N
D
R
DS
VT
L
VH
K
G
N
I
M
KF
T
EGA
F
K
D
W
G
YQ
L
A
R
E
EFGGELIDGGPWLKVKNPNTGK
EI
VIKDVI
A
D
AFLQ
Q
I
L
LR
P
A
E
Y
DVI
A
C
M
NL
N
GD
YI
SD
AL
AA
Q
V
G
G
IGIAP
G
AN
IG
D
E
C-
-
-
A
LFE
A
T
HG
T
AP
KY
AG
QDKV
NP
GS
I
ILS
A
E
MMLRH
M
G
--
-
-
-
WTE
AA
DL
I
VK
GM
E
G
AI
NA
K
TV
T
Y
D
FE
R
LME
GA
K
LLK
C
S
E
F
G
E
AI
fig|316385.7.peg.1234
Escherichia coli str. K-12 substr. DH10B (25-412/416)
E
N
PI
I
P
Y
I
E
GDGIG
V
D
V
T
P
AM
LKV
V
DAA
V
E
K
A
YKG
ERK
IS
WMEIYT
G
EKS
-
TQV
Y
GQ
D
VW
LP
AE
T
L
D
LIR
E
Y
RV
AI
K
G
-
--
---
-
----
P
L
TT
P
VG
G
G
IRSLNV
A
LRQE
L
DLY
I
C
LRPVR
Y
YQG
T
P
--
S
P
V
-
-
-
K
H
P
ELT
D
MVI
F
REN
S
E
D
IY
-
AGIE
WK
AD
S
A
-
D
A
EKVI
K--
-
F
L
R
E
EM
GVKKIRFPEHCGIGIKPCSEEGT
KR
L
V
R
A
A
I
E
Y
A
IA
N
D
R
DS
VT
L
VH
K
G
N
I
M
KF
T
EGA
F
K
D
W
G
YQ
L
A
R
E
EFGGELIDGGPWLKVKNPNTGK
EI
VIKDVI
A
D
AFLQ
Q
I
L
LR
P
A
E
Y
DVI
A
C
M
NL
N
GD
YI
SD
AL
AA
Q
V
G
G
IGIAP
G
AN
IG
D
E
C-
-
-
A
LFE
A
T
HG
T
AP
KY
AG
QDKV
NP
GS
I
ILS
A
E
MMLRH
M
G
--
-
-
-
WTE
AA
DL
I
VK
GM
E
G
AI
NA
K
TV
T
Y
D
FE
R
LME
GA
K
LLK
C
S
E
F
G
E
AI
Consen1
Primary consensus
Mskn
Ia
ipGDGIG
eV
p
lkVldAa
er
---
is
g
-
hGq
--
lP
t
e
q
da
fG
vg
---
w
Pd
p
G
l
----
l
lRqefdly
nLRPvrlyqG
p
--
cPl
-
a
k
p
D
vREntegiY
-
gr
sg
-
q
Ekvi
vf
R
em
-----------------------
kRi
R
AfE
A
r
R
vTs
K
N
l
s
w
e
v
iA
ey
--------------------
pei
iD
q
i
P
qfDVi
csNLfGDilSD
aa
tG
iGiaPsAnln
E
f
-
LfEp
hGsAPdiaGkniaNPia
Ils
ammLrh
g
d
-
Aa
I
aie
ai
g
T
D
r
---
Gaa
t
e
gDaI
kyvAEGV
Consen2
Secondary consensus
met
p
le
d
t
ir
vq
v
nk
ykg
lt
a
y
y
k
vwm
w
d
rv
k
--
gpk
-
l
s
irslnv
f
hlkqf
c
akyfp
eafs
vr
-
i
a
f
lsgde
f
wk
eat
vaf
-
y
g
gvkkirfpehcgigikpcseegt
l
i
n
l
l
m
t
f
d
g
nefggelidggpwlkvknpntgkdv
a
r
y
am
n
yi
pm
v
m
ml
g
sig
-
p
y
a
g
t
kyy
qdkv
gs
wa
ell
d
l
-
r
h
gmn
vl
k
klme
nk
c
q
a
i
rii
Consensus 1
(when a gap)
Conservative difference
Consensus 2
(when a gap)
Nonconservative diff.
Other character