fig|1040638.4.peg.5603
Escherichia coli O104:H4 str. LB226692
MQPSRNFDDL
KF
S
SI
H
R
RI
LLWG
SG
GP
F
LDGYVL
VM
IGVAL
E
QLTPA
LK
L
DA
D
WI
G
LL
G
AGT
L
A
GLFVG
TS
LF
GYISD
KV
GRRK
M
F
L
ID
I
I
A
IGV
I
S
VATM
FV
SS
P
VE
L
L
VM
R
V
LIGI
V
IGADY
P
IA
T
S
MI
TEFS
S
T
R
Q
R
A
FSISFIA
--------
AM
W
Y
VG
ATC
A
D
L
VG
-
YWLYDVEGG
WRWML
G
SAAIP
C
LLI
LIG
R
F
EL
--------------------
PESPRWLLRKGR
V
K
E
C
E
EM
M
I
K
L
FG
EP
V
AFDE
EQ
PQQ
T
-
-
R
F
R
-----
--
--------------
D
LF
NR
R
HF
PFV
LF
VAAIWT
C
Q
--
VIP
M
F
A
IYT
F
G
P
Q
I
VGLL
GL
G
V
G
K
N
A
ALG
N
VVIS
L
FF
MLG
C
-----
I
PP
M
L
WL
N
TAG
RR
PL
L
I
GS
F
AM
M
TLA
LAVLG
L
IP
D
M
G
IW
--------
LVVM
A
F
A
-
VY
AF
F
S
GG
PG
NL
QW
LYP
N
ELFPTDIR
AS
A
VG
V
IM
S
LSRIG
T
I
VST
WA
LP
I
------
F
I
N
N
YG
-
I
S
N
TML
M
GA
G
I
S
L
F
GL
L
IS
VA
FAPETR
G
MSL
AQT
SN
M
TIRGQRMG
fig|6666666.5357.peg.1584
Escherichia coli TY-2482
MQPSRNFDDL
KF
S
SI
H
R
RI
LLWG
SG
GP
F
LDGYVL
VM
IGVAL
E
QLTPA
LK
L
DA
D
WI
G
LL
G
AGT
L
A
GLFVG
TS
LF
GYISD
KV
GRRK
M
F
L
ID
I
I
A
IGV
I
S
VATM
FV
SS
P
VE
L
L
VM
R
V
LIGI
V
IGADY
P
IA
T
S
MI
TEFS
S
T
R
Q
R
A
FSISFIA
--------
AM
W
Y
VG
ATC
A
D
L
VG
-
YWLYDVEGG
WRWML
G
SAAIP
C
LLI
LIG
R
F
EL
--------------------
PESPRWLLRKGR
V
K
E
C
E
EM
M
I
K
L
FG
EP
V
AFDE
EQ
PQQ
T
-
-
R
F
R
-----
--
--------------
D
LF
NR
R
HF
PFV
LF
VAAIWT
C
Q
--
VIP
M
F
A
IYT
F
G
P
Q
I
VGLL
GL
G
V
G
K
N
A
ALG
N
VVIS
L
FF
MLG
C
-----
I
PP
M
L
WL
N
TAG
RR
PL
L
I
GS
F
AM
M
TLA
LAVLG
L
IP
D
M
G
IW
--------
LVVM
A
F
A
-
VY
AF
F
S
GG
PG
NL
QW
LYP
N
ELFPTDIR
AS
A
VG
V
IM
S
LSRIG
T
I
VST
WA
LP
I
------
F
I
N
N
YG
-
I
S
N
TML
M
GA
G
I
S
L
F
GL
L
IS
VA
FAPETR
G
MSL
AQT
SN
M
TIRGQRMG
fig|358709.5.peg.4436
Escherichia coli 101-1
MQPSRNFDDL
KF
S
SI
H
R
RI
LLWG
SG
GP
F
LDGYVL
VM
IGVAL
E
QLTPA
LK
L
DA
D
WI
G
LL
G
AGT
L
A
GLFVG
TS
LF
GYISD
KV
GRRK
M
F
L
ID
I
I
A
IGV
I
S
VATM
FV
SS
P
VE
L
L
VM
R
V
LIGI
V
IGADY
P
IA
T
S
MI
TEFS
S
T
R
Q
R
A
FSISFIA
--------
AM
W
Y
VG
ATC
A
D
L
VG
-
YWLYDVEGG
WRWML
G
SAAIP
C
LLI
LIG
R
F
EL
--------------------
PESPRWLLRKGR
V
K
E
C
E
EM
M
I
K
L
FG
EP
V
AFDE
EQ
PQQ
T
-
-
R
F
R
-----
--
--------------
D
LF
NR
R
HF
PFV
LF
VAAIWT
C
Q
--
VIP
M
F
A
IYT
F
G
P
Q
I
VGLL
GL
G
V
G
K
N
A
ALG
N
VVIS
L
FF
MLG
C
-----
I
PP
M
L
WL
N
TAG
RR
PL
L
I
GS
F
AM
M
TLA
LAVLG
L
IP
D
M
G
IW
--------
LVVM
A
F
A
-
VY
AF
F
S
GG
PG
NL
QW
LYP
N
ELFPTDIR
AS
A
VG
V
IM
S
LSRIG
T
I
VST
WA
LP
I
------
F
I
N
N
YG
-
I
S
N
TML
M
GA
G
I
S
L
F
GL
L
IS
VA
FAPETR
G
MSL
AQT
SN
M
TIRGQRMG
fig|670888.3.peg.624
Escherichia coli 1827-70
MQPSRNFDDL
KF
S
SI
H
R
RI
LLWG
SG
GP
F
LDGYVL
VM
IGVAL
E
QLTPA
LK
L
DA
D
WI
G
LL
G
AGT
L
A
GLFVG
TS
LF
GYISD
KV
GRRK
M
F
L
ID
I
I
A
IGV
I
S
VATM
FV
SS
P
VE
L
L
VM
R
V
LIGI
V
IGADY
P
IA
T
S
MI
TEFS
S
T
R
Q
R
A
FSISFIA
--------
AM
W
Y
VG
ATC
A
D
L
VG
-
YWLYDVEGG
WRWML
G
SAAIP
C
LLI
LIG
R
F
EL
--------------------
PESPRWLLRKGR
V
K
E
C
E
EM
M
I
K
L
FG
EP
V
AFDE
EQ
PQQ
T
-
-
R
F
R
-----
--
--------------
D
LF
NR
R
HF
PFV
LF
VAAIWT
C
Q
--
VIP
M
F
A
IYT
F
G
P
Q
I
VGLL
GL
G
V
G
K
N
A
ALG
N
VVIS
L
FF
MLG
C
-----
I
PP
M
L
WL
N
TAG
RR
PL
L
I
GS
F
AM
M
TLA
LAVLG
L
IP
D
M
G
IW
--------
LVVM
A
F
A
-
VY
AF
F
S
GG
PG
NL
QW
LYP
N
ELFPTDIR
AS
A
VG
V
IM
S
LSRIG
T
I
VST
WA
LP
I
------
F
I
N
N
YG
-
I
S
N
TML
M
GA
G
I
S
L
F
GL
L
IS
VA
FAPETR
G
MSL
AQT
SN
M
TIRGQRMG
fig|362663.8.peg.48
Escherichia coli 536
MQPSRNFDDL
KF
S
SI
H
R
RI
LLWG
SG
GP
F
LDGYVL
VM
IGVAL
E
QLTPA
LK
L
DA
D
WI
G
LL
G
AGT
L
A
GLFVG
TS
LF
GYISD
KV
GRRK
M
F
L
ID
I
I
A
IGV
I
S
VATM
FV
SS
P
VE
L
L
VM
R
V
LIGI
V
IGADY
P
IA
T
S
MI
TEFS
S
T
R
Q
R
A
FSISFIA
--------
AM
W
Y
VG
ATC
A
D
L
VG
-
YWLYDVEGG
WRWML
G
SAAIP
C
LLI
LIG
R
F
EL
--------------------
PESPRWLLRKGR
V
K
E
C
E
EM
M
I
K
L
FG
EP
V
AFDE
EQ
PQQ
T
-
-
R
F
R
-----
--
--------------
D
LF
NR
R
HF
PFV
LF
VAAIWT
C
Q
--
VIP
M
F
A
IYT
F
G
P
Q
I
VGLL
GL
G
V
G
K
N
A
ALG
N
VVIS
L
FF
MLG
C
-----
I
PP
M
L
WL
N
TAG
RR
PL
L
I
GS
F
AM
M
TLA
LAVLG
L
IP
D
M
G
IW
--------
LVVM
A
F
A
-
VY
AF
F
S
GG
PG
NL
QW
LYP
N
ELFPTDIR
AS
A
VG
V
IM
S
LSRIG
T
I
VST
WA
LP
I
------
F
I
N
N
YG
-
I
S
N
TML
M
GA
G
I
S
L
F
GL
L
IS
VA
FAPETR
G
MSL
AQT
SN
M
TIRGQRMG
fig|362663.9.peg.48
Escherichia coli 536
MQPSRNFDDL
KF
S
SI
H
R
RI
LLWG
SG
GP
F
LDGYVL
VM
IGVAL
E
QLTPA
LK
L
DA
D
WI
G
LL
G
AGT
L
A
GLFVG
TS
LF
GYISD
KV
GRRK
M
F
L
ID
I
I
A
IGV
I
S
VATM
FV
SS
P
VE
L
L
VM
R
V
LIGI
V
IGADY
P
IA
T
S
MI
TEFS
S
T
R
Q
R
A
FSISFIA
--------
AM
W
Y
VG
ATC
A
D
L
VG
-
YWLYDVEGG
WRWML
G
SAAIP
C
LLI
LIG
R
F
EL
--------------------
PESPRWLLRKGR
V
K
E
C
E
EM
M
I
K
L
FG
EP
V
AFDE
EQ
PQQ
T
-
-
R
F
R
-----
--
--------------
D
LF
NR
R
HF
PFV
LF
VAAIWT
C
Q
--
VIP
M
F
A
IYT
F
G
P
Q
I
VGLL
GL
G
V
G
K
N
A
ALG
N
VVIS
L
FF
MLG
C
-----
I
PP
M
L
WL
N
TAG
RR
PL
L
I
GS
F
AM
M
TLA
LAVLG
L
IP
D
M
G
IW
--------
LVVM
A
F
A
-
VY
AF
F
S
GG
PG
NL
QW
LYP
N
ELFPTDIR
AS
A
VG
V
IM
S
LSRIG
T
I
VST
WA
LP
I
------
F
I
N
N
YG
-
I
S
N
TML
M
GA
G
I
S
L
F
GL
L
IS
VA
FAPETR
G
MSL
AQT
SN
M
TIRGQRMG
fig|344610.3.peg.796
Escherichia coli 53638
MQPSRNFDDL
KF
S
SI
H
R
RI
LLWG
SG
GP
F
LDGYVL
VM
IGVAL
E
QLTPA
LK
L
DA
D
WI
G
LL
G
AGT
L
A
GLFVG
TS
LF
GYISD
KV
GRRK
M
F
L
ID
I
I
A
IGV
I
S
VATM
FV
SS
P
VE
L
L
VM
R
V
LIGI
V
IGADY
P
IA
T
S
MI
TEFS
S
T
R
Q
R
A
FSISFIA
--------
AM
W
Y
VG
ATC
A
D
L
VG
-
YWLYDVEGG
WRWML
G
SAAIP
C
LLI
LIG
R
F
EL
--------------------
PESPRWLLRKGR
V
K
E
C
E
EM
M
I
K
L
FG
EP
V
AFDE
EQ
PQQ
T
-
-
R
F
R
-----
--
--------------
D
LF
NR
R
HF
PFV
LF
VAAIWT
C
Q
--
VIP
M
F
A
IYT
F
G
P
Q
I
VGLL
GL
G
V
G
K
N
A
ALG
N
VVIS
L
FF
MLG
C
-----
I
PP
M
L
WL
N
TAG
RR
PL
L
I
GS
F
AM
M
TLA
LAVLG
L
IP
D
M
G
IW
--------
LVVM
A
F
A
-
VY
AF
F
S
GG
PG
NL
QW
LYP
N
ELFPTDIR
AS
A
VG
V
IM
S
LSRIG
T
I
VST
WA
LP
I
------
F
I
N
N
YG
-
I
S
N
TML
M
GA
G
I
S
L
F
GL
L
IS
VA
FAPETR
G
MSL
AQT
SN
M
TIRGQRMG
fig|344610.7.peg.1695
Escherichia coli 53638
MQPSRNFDDL
KF
S
SI
H
R
RI
LLWG
SG
GP
F
LDGYVL
VM
IGVAL
E
QLTPA
LK
L
DA
D
WI
G
LL
G
AGT
L
A
GLFVG
TS
LF
GYISD
KV
GRRK
M
F
L
ID
I
I
A
IGV
I
S
VATM
FV
SS
P
VE
L
L
VM
R
V
LIGI
V
IGADY
P
IA
T
S
MI
TEFS
S
T
R
Q
R
A
FSISFIA
--------
AM
W
Y
VG
ATC
A
D
L
VG
-
YWLYDVEGG
WRWML
G
SAAIP
C
LLI
LIG
R
F
EL
--------------------
PESPRWLLRKGR
V
K
E
C
E
EM
M
I
K
L
FG
EP
V
AFDE
EQ
PQQ
T
-
-
R
F
R
-----
--
--------------
D
LF
NR
R
HF
PFV
LF
VAAIWT
C
Q
--
VIP
M
F
A
IYT
F
G
P
Q
I
VGLL
GL
G
V
G
K
N
A
ALG
N
VVIS
L
FF
MLG
C
-----
I
PP
M
L
WL
N
TAG
RR
PL
L
I
GS
F
AM
M
TLA
LAVLG
L
IP
D
M
G
IW
--------
LVVM
A
F
A
-
VY
AF
F
S
GG
PG
NL
QW
LYP
N
ELFPTDIR
AS
A
VG
V
IM
S
LSRIG
T
I
VST
WA
LP
I
------
F
I
N
N
YG
-
I
S
N
TML
M
GA
G
I
S
L
F
GL
L
IS
VA
FAPETR
G
MSL
AQT
SN
M
TIRGQRMG
fig|585055.6.peg.47
Escherichia coli 55989
MQPSRNFDDL
KF
S
SI
H
R
RI
LLWG
SG
GP
F
LDGYVL
VM
IGVAL
E
QLTPA
LK
L
DA
D
WI
G
LL
G
AGT
L
A
GLFVG
TS
LF
GYISD
KV
GRRK
M
F
L
ID
I
I
A
IGV
I
S
VATM
FV
SS
P
VE
L
L
VM
R
V
LIGI
V
IGADY
P
IA
T
S
MI
TEFS
S
T
R
Q
R
A
FSISFIA
--------
AM
W
Y
VG
ATC
A
D
L
VG
-
YWLYDVEGG
WRWML
G
SAAIP
C
LLI
LIG
R
F
EL
--------------------
PESPRWLLRKGR
V
K
E
C
E
EM
M
I
K
L
FG
EP
V
AFDE
EQ
PQQ
T
-
-
R
F
R
-----
--
--------------
D
LF
NR
R
HF
PFV
LF
VAAIWT
C
Q
--
VIP
M
F
A
IYT
F
G
P
Q
I
VGLL
GL
G
V
G
K
N
A
ALG
N
VVIS
L
FF
MLG
C
-----
I
PP
M
L
WL
N
TAG
RR
PL
L
I
GS
F
AM
M
TLA
LAVLG
L
IP
D
M
G
IW
--------
LVVM
A
F
A
-
VY
AF
F
S
GG
PG
NL
QW
LYP
N
ELFPTDIR
AS
A
VG
V
IM
S
LSRIG
T
I
VST
WA
LP
I
------
F
I
N
N
YG
-
I
S
N
TML
M
GA
G
I
S
L
F
GL
L
IS
VA
FAPETR
G
MSL
AQT
SN
M
TIRGQRMG
fig|585055.8.peg.47
Escherichia coli 55989
MQPSRNFDDL
KF
S
SI
H
R
RI
LLWG
SG
GP
F
LDGYVL
VM
IGVAL
E
QLTPA
LK
L
DA
D
WI
G
LL
G
AGT
L
A
GLFVG
TS
LF
GYISD
KV
GRRK
M
F
L
ID
I
I
A
IGV
I
S
VATM
FV
SS
P
VE
L
L
VM
R
V
LIGI
V
IGADY
P
IA
T
S
MI
TEFS
S
T
R
Q
R
A
FSISFIA
--------
AM
W
Y
VG
ATC
A
D
L
VG
-
YWLYDVEGG
WRWML
G
SAAIP
C
LLI
LIG
R
F
EL
--------------------
PESPRWLLRKGR
V
K
E
C
E
EM
M
I
K
L
FG
EP
V
AFDE
EQ
PQQ
T
-
-
R
F
R
-----
--
--------------
D
LF
NR
R
HF
PFV
LF
VAAIWT
C
Q
--
VIP
M
F
A
IYT
F
G
P
Q
I
VGLL
GL
G
V
G
K
N
A
ALG
N
VVIS
L
FF
MLG
C
-----
I
PP
M
L
WL
N
TAG
RR
PL
L
I
GS
F
AM
M
TLA
LAVLG
L
IP
D
M
G
IW
--------
LVVM
A
F
A
-
VY
AF
F
S
GG
PG
NL
QW
LYP
N
ELFPTDIR
AS
A
VG
V
IM
S
LSRIG
T
I
VST
WA
LP
I
------
F
I
N
N
YG
-
I
S
N
TML
M
GA
G
I
S
L
F
GL
L
IS
VA
FAPETR
G
MSL
AQT
SN
M
TIRGQRMG
fig|481805.3.peg.3875
Escherichia coli ATCC 8739
MQPSRNFDDL
KF
S
SI
H
R
RI
LLWG
SG
GP
F
LDGYVL
VM
IGVAL
E
QLTPA
LK
L
DA
D
WI
G
LL
G
AGT
L
A
GLFVG
TS
LF
GYISD
KV
GRRK
M
F
L
ID
I
I
A
IGV
I
S
VATM
FV
SS
P
VE
L
L
VM
R
V
LIGI
V
IGADY
P
IA
T
S
MI
TEFS
S
T
R
Q
R
A
FSISFIA
--------
AM
W
Y
VG
ATC
A
D
L
VG
-
YWLYDVEGG
WRWML
G
SAAIP
C
LLI
LIG
R
F
EL
--------------------
PESPRWLLRKGR
V
K
E
C
E
EM
M
I
K
L
FG
EP
V
AFDE
EQ
PQQ
T
-
-
R
F
R
-----
--
--------------
D
LF
NR
R
HF
PFV
LF
VAAIWT
C
Q
--
VIP
M
F
A
IYT
F
G
P
Q
I
VGLL
GL
G
V
G
K
N
A
ALG
N
VVIS
L
FF
MLG
C
-----
I
PP
M
L
WL
N
TAG
RR
PL
L
I
GS
F
AM
M
TLA
LAVLG
L
IP
D
M
G
IW
--------
LVVM
A
F
A
-
VY
AF
F
S
GG
PG
NL
QW
LYP
N
ELFPTDIR
AS
A
VG
V
IM
S
LSRIG
T
I
VST
WA
LP
I
------
F
I
N
N
YG
-
I
S
N
TML
M
GA
G
I
S
L
F
GL
L
IS
VA
FAPETR
G
MSL
AQT
SN
M
TIRGQRMG
fig|481805.6.peg.3855
Escherichia coli ATCC 8739
MQPSRNFDDL
KF
S
SI
H
R
RI
LLWG
SG
GP
F
LDGYVL
VM
IGVAL
E
QLTPA
LK
L
DA
D
WI
G
LL
G
AGT
L
A
GLFVG
TS
LF
GYISD
KV
GRRK
M
F
L
ID
I
I
A
IGV
I
S
VATM
FV
SS
P
VE
L
L
VM
R
V
LIGI
V
IGADY
P
IA
T
S
MI
TEFS
S
T
R
Q
R
A
FSISFIA
--------
AM
W
Y
VG
ATC
A
D
L
VG
-
YWLYDVEGG
WRWML
G
SAAIP
C
LLI
LIG
R
F
EL
--------------------
PESPRWLLRKGR
V
K
E
C
E
EM
M
I
K
L
FG
EP
V
AFDE
EQ
PQQ
T
-
-
R
F
R
-----
--
--------------
D
LF
NR
R
HF
PFV
LF
VAAIWT
C
Q
--
VIP
M
F
A
IYT
F
G
P
Q
I
VGLL
GL
G
V
G
K
N
A
ALG
N
VVIS
L
FF
MLG
C
-----
I
PP
M
L
WL
N
TAG
RR
PL
L
I
GS
F
AM
M
TLA
LAVLG
L
IP
D
M
G
IW
--------
LVVM
A
F
A
-
VY
AF
F
S
GG
PG
NL
QW
LYP
N
ELFPTDIR
AS
A
VG
V
IM
S
LSRIG
T
I
VST
WA
LP
I
------
F
I
N
N
YG
-
I
S
N
TML
M
GA
G
I
S
L
F
GL
L
IS
VA
FAPETR
G
MSL
AQT
SN
M
TIRGQRMG
fig|413997.3.peg.52
Escherichia coli B str. REL606
MQPSRNFDDL
KF
S
SI
H
R
RI
LLWG
SG
GP
F
LDGYVL
VM
IGVAL
E
QLTPA
LK
L
DA
D
WI
G
LL
G
AGT
L
A
GLFVG
TS
LF
GYISD
KV
GRRK
M
F
L
ID
I
I
A
IGV
I
S
VATM
FV
SS
P
VE
L
L
VM
R
V
LIGI
V
IGADY
P
IA
T
S
MI
TEFS
S
T
R
Q
R
A
FSISFIA
--------
AM
W
Y
VG
ATC
A
D
L
VG
-
YWLYDVEGG
WRWML
G
SAAIP
C
LLI
LIG
R
F
EL
--------------------
PESPRWLLRKGR
V
K
E
C
E
EM
M
I
K
L
FG
EP
V
AFDE
EQ
PQQ
T
-
-
R
F
R
-----
--
--------------
D
LF
NR
R
HF
PFV
LF
VAAIWT
C
Q
--
VIP
M
F
A
IYT
F
G
P
Q
I
VGLL
GL
G
V
G
K
N
A
ALG
N
VVIS
L
FF
MLG
C
-----
I
PP
M
L
WL
N
TAG
RR
PL
L
I
GS
F
AM
M
TLA
LAVLG
L
IP
D
M
G
IW
--------
LVVM
A
F
A
-
VY
AF
F
S
GG
PG
NL
QW
LYP
N
ELFPTDIR
AS
A
VG
V
IM
S
LSRIG
T
I
VST
WA
LP
I
------
F
I
N
N
YG
-
I
S
N
TML
M
GA
G
I
S
L
F
GL
L
IS
VA
FAPETR
G
MSL
AQT
SN
M
TIRGQRMG
fig|550672.3.peg.4319
Escherichia coli B088
MQPSRNFDDL
KF
S
SI
H
R
RI
LLWG
SG
GP
F
LDGYVL
VM
IGVAL
E
QLTPA
LK
L
DA
D
WI
G
LL
G
AGT
L
A
GLFVG
TS
LF
GYISD
KV
GRRK
M
F
L
ID
I
I
A
IGV
I
S
VATM
FV
SS
P
VE
L
L
VM
R
V
LIGI
V
IGADY
P
IA
T
S
MI
TEFS
S
T
R
Q
R
A
FSISFIA
--------
AM
W
Y
VG
ATC
A
D
L
VG
-
YWLYDVEGG
WRWML
G
SAAIP
C
LLI
LIG
R
F
EL
--------------------
PESPRWLLRKGR
V
K
E
C
E
EM
M
I
K
L
FG
EP
V
AFDE
EQ
PQQ
T
-
-
R
F
R
-----
--
--------------
D
LF
NR
R
HF
PFV
LF
VAAIWT
C
Q
--
VIP
M
F
A
IYT
F
G
P
Q
I
VGLL
GL
G
V
G
K
N
A
ALG
N
VVIS
L
FF
MLG
C
-----
I
PP
M
L
WL
N
TAG
RR
PL
L
I
GS
F
AM
M
TLA
LAVLG
L
IP
D
M
G
IW
--------
LVVM
A
F
A
-
VY
AF
F
S
GG
PG
NL
QW
LYP
N
ELFPTDIR
AS
A
VG
V
IM
S
LSRIG
T
I
VST
WA
LP
I
------
F
I
N
N
YG
-
I
S
N
TML
M
GA
G
I
S
L
F
GL
L
IS
VA
FAPETR
G
MSL
AQT
SN
M
TIRGQRMG
fig|344601.3.peg.4209
Escherichia coli B171
MQPSRNFDDL
KF
S
SI
H
R
RI
LLWG
SG
GP
F
LDGYVL
VM
IGVAL
E
QLTPA
LK
L
DA
D
WI
G
LL
G
AGT
L
A
GLFVG
TS
LF
GYISD
KV
GRRK
M
F
L
ID
I
I
A
IGV
I
S
VATM
FV
SS
P
VE
L
L
VM
R
V
LIGI
V
IGADY
P
IA
T
S
MI
TEFS
S
T
R
Q
R
A
FSISFIA
--------
AM
W
Y
VG
ATC
A
D
L
VG
-
YWLYDVEGG
WRWML
G
SAAIP
C
LLI
LIG
R
F
EL
--------------------
PESPRWLLRKGR
V
K
E
C
E
EM
M
I
K
L
FG
EP
V
AFDE
EQ
PQQ
T
-
-
R
F
R
-----
--
--------------
D
LF
NR
R
HF
PFV
LF
VAAIWT
C
Q
--
VIP
M
F
A
IYT
F
G
P
Q
I
VGLL
GL
G
V
G
K
N
A
ALG
N
VVIS
L
FF
MLG
C
-----
I
PP
M
L
WL
N
TAG
RR
PL
L
I
GS
F
AM
M
TLA
LAVLG
L
IP
D
M
G
IW
--------
LVVM
A
F
A
-
VY
AF
F
S
GG
PG
NL
QW
LYP
N
ELFPTDIR
AS
A
VG
V
IM
S
LSRIG
T
I
VST
WA
LP
I
------
F
I
N
N
YG
-
I
S
N
TML
M
GA
G
I
S
L
F
GL
L
IS
VA
FAPETR
G
MSL
AQT
SN
M
TIRGQRMG
fig|344601.5.peg.4432
Escherichia coli B171
MQPSRNFDDL
KF
S
SI
H
R
RI
LLWG
SG
GP
F
LDGYVL
VM
IGVAL
E
QLTPA
LK
L
DA
D
WI
G
LL
G
AGT
L
A
GLFVG
TS
LF
GYISD
KV
GRRK
M
F
L
ID
I
I
A
IGV
I
S
VATM
FV
SS
P
VE
L
L
VM
R
V
LIGI
V
IGADY
P
IA
T
S
MI
TEFS
S
T
R
Q
R
A
FSISFIA
--------
AM
W
Y
VG
ATC
A
D
L
VG
-
YWLYDVEGG
WRWML
G
SAAIP
C
LLI
LIG
R
F
EL
--------------------
PESPRWLLRKGR
V
K
E
C
E
EM
M
I
K
L
FG
EP
V
AFDE
EQ
PQQ
T
-
-
R
F
R
-----
--
--------------
D
LF
NR
R
HF
PFV
LF
VAAIWT
C
Q
--
VIP
M
F
A
IYT
F
G
P
Q
I
VGLL
GL
G
V
G
K
N
A
ALG
N
VVIS
L
FF
MLG
C
-----
I
PP
M
L
WL
N
TAG
RR
PL
L
I
GS
F
AM
M
TLA
LAVLG
L
IP
D
M
G
IW
--------
LVVM
A
F
A
-
VY
AF
F
S
GG
PG
NL
QW
LYP
N
ELFPTDIR
AS
A
VG
V
IM
S
LSRIG
T
I
VST
WA
LP
I
------
F
I
N
N
YG
-
I
S
N
TML
M
GA
G
I
S
L
F
GL
L
IS
VA
FAPETR
G
MSL
AQT
SN
M
TIRGQRMG
fig|550676.3.peg.4711
Escherichia coli B185
MQPSRNFDDL
KF
S
SI
H
R
RI
LLWG
SG
GP
F
LDGYVL
VM
IGVAL
E
QLTPA
LK
L
DA
D
WI
G
LL
G
AGT
L
A
GLFVG
TS
LF
GYISD
KV
GRRK
M
F
L
ID
I
I
A
IGV
I
S
VATM
FV
SS
P
VE
L
L
VM
R
V
LIGI
V
IGADY
P
IA
T
S
MI
TEFS
S
T
R
Q
R
A
FSISFIA
--------
AM
W
Y
VG
ATC
A
D
L
VG
-
YWLYDVEGG
WRWML
G
SAAIP
C
LLI
LIG
R
F
EL
--------------------
PESPRWLLRKGR
V
K
E
C
E
EM
M
I
K
L
FG
EP
V
AFDE
EQ
PQQ
T
-
-
R
F
R
-----
--
--------------
D
LF
NR
R
HF
PFV
LF
VAAIWT
C
Q
--
VIP
M
F
A
IYT
F
G
P
Q
I
VGLL
GL
G
V
G
K
N
A
ALG
N
VVIS
L
FF
MLG
C
-----
I
PP
M
L
WL
N
TAG
RR
PL
L
I
GS
F
AM
M
TLA
LAVLG
L
IP
D
M
G
IW
--------
LVVM
A
F
A
-
VY
AF
F
S
GG
PG
NL
QW
LYP
N
ELFPTDIR
AS
A
VG
V
IM
S
LSRIG
T
I
VST
WA
LP
I
------
F
I
N
N
YG
-
I
S
N
TML
M
GA
G
I
S
L
F
GL
L
IS
VA
FAPETR
G
MSL
AQT
SN
M
TIRGQRMG
fig|550677.3.peg.431
Escherichia coli B354
MQPSRNFDDL
KF
S
SI
H
R
RI
LLWG
SG
GP
F
LDGYVL
VM
IGVAL
E
QLTPA
LK
L
DA
D
WI
G
LL
G
AGT
L
A
GLFVG
TS
LF
GYISD
KV
GRRK
M
F
L
ID
I
I
A
IGV
I
S
VATM
FV
SS
P
VE
L
L
VM
R
V
LIGI
V
IGADY
P
IA
T
S
MI
TEFS
S
T
R
Q
R
A
FSISFIA
--------
AM
W
Y
VG
ATC
A
D
L
VG
-
YWLYDVEGG
WRWML
G
SAAIP
C
LLI
LIG
R
F
EL
--------------------
PESPRWLLRKGR
V
K
E
C
E
EM
M
I
K
L
FG
EP
V
AFDE
EQ
PQQ
T
-
-
R
F
R
-----
--
--------------
D
LF
NR
R
HF
PFV
LF
VAAIWT
C
Q
--
VIP
M
F
A
IYT
F
G
P
Q
I
VGLL
GL
G
V
G
K
N
A
ALG
N
VVIS
L
FF
MLG
C
-----
I
PP
M
L
WL
N
TAG
RR
PL
L
I
GS
F
AM
M
TLA
LAVLG
L
IP
D
M
G
IW
--------
LVVM
A
F
A
-
VY
AF
F
S
GG
PG
NL
QW
LYP
N
ELFPTDIR
AS
A
VG
V
IM
S
LSRIG
T
I
VST
WA
LP
I
------
F
I
N
N
YG
-
I
S
N
TML
M
GA
G
I
S
L
F
GL
L
IS
VA
FAPETR
G
MSL
AQT
SN
M
TIRGQRMG
fig|511693.5.peg.53
Escherichia coli BL21
MQPSRNFDDL
KF
S
SI
H
R
RI
LLWG
SG
GP
F
LDGYVL
VM
IGVAL
E
QLTPA
LK
L
DA
D
WI
G
LL
G
AGT
L
A
GLFVG
TS
LF
GYISD
KV
GRRK
M
F
L
ID
I
I
A
IGV
I
S
VATM
FV
SS
P
VE
L
L
VM
R
V
LIGI
V
IGADY
P
IA
T
S
MI
TEFS
S
T
R
Q
R
A
FSISFIA
--------
AM
W
Y
VG
ATC
A
D
L
VG
-
YWLYDVEGG
WRWML
G
SAAIP
C
LLI
LIG
R
F
EL
--------------------
PESPRWLLRKGR
V
K
E
C
E
EM
M
I
K
L
FG
EP
V
AFDE
EQ
PQQ
T
-
-
R
F
R
-----
--
--------------
D
LF
NR
R
HF
PFV
LF
VAAIWT
C
Q
--
VIP
M
F
A
IYT
F
G
P
Q
I
VGLL
GL
G
V
G
K
N
A
ALG
N
VVIS
L
FF
MLG
C
-----
I
PP
M
L
WL
N
TAG
RR
PL
L
I
GS
F
AM
M
TLA
LAVLG
L
IP
D
M
G
IW
--------
LVVM
A
F
A
-
VY
AF
F
S
GG
PG
NL
QW
LYP
N
ELFPTDIR
AS
A
VG
V
IM
S
LSRIG
T
I
VST
WA
LP
I
------
F
I
N
N
YG
-
I
S
N
TML
M
GA
G
I
S
L
F
GL
L
IS
VA
FAPETR
G
MSL
AQT
SN
M
TIRGQRMG
fig|469008.4.peg.3692
Escherichia coli BL21(DE3)
MQPSRNFDDL
KF
S
SI
H
R
RI
LLWG
SG
GP
F
LDGYVL
VM
IGVAL
E
QLTPA
LK
L
DA
D
WI
G
LL
G
AGT
L
A
GLFVG
TS
LF
GYISD
KV
GRRK
M
F
L
ID
I
I
A
IGV
I
S
VATM
FV
SS
P
VE
L
L
VM
R
V
LIGI
V
IGADY
P
IA
T
S
MI
TEFS
S
T
R
Q
R
A
FSISFIA
--------
AM
W
Y
VG
ATC
A
D
L
VG
-
YWLYDVEGG
WRWML
G
SAAIP
C
LLI
LIG
R
F
EL
--------------------
PESPRWLLRKGR
V
K
E
C
E
EM
M
I
K
L
FG
EP
V
AFDE
EQ
PQQ
T
-
-
R
F
R
-----
--
--------------
D
LF
NR
R
HF
PFV
LF
VAAIWT
C
Q
--
VIP
M
F
A
IYT
F
G
P
Q
I
VGLL
GL
G
V
G
K
N
A
ALG
N
VVIS
L
FF
MLG
C
-----
I
PP
M
L
WL
N
TAG
RR
PL
L
I
GS
F
AM
M
TLA
LAVLG
L
IP
D
M
G
IW
--------
LVVM
A
F
A
-
VY
AF
F
S
GG
PG
NL
QW
LYP
N
ELFPTDIR
AS
A
VG
V
IM
S
LSRIG
T
I
VST
WA
LP
I
------
F
I
N
N
YG
-
I
S
N
TML
M
GA
G
I
S
L
F
GL
L
IS
VA
FAPETR
G
MSL
AQT
SN
M
TIRGQRMG
fig|595496.3.peg.47
Escherichia coli BW2952
MQPSRNFDDL
KF
S
SI
H
R
RI
LLWG
SG
GP
F
LDGYVL
VM
IGVAL
E
QLTPA
LK
L
DA
D
WI
G
LL
G
AGT
L
A
GLFVG
TS
LF
GYISD
KV
GRRK
M
F
L
ID
I
I
A
IGV
I
S
VATM
FV
SS
P
VE
L
L
VM
R
V
LIGI
V
IGADY
P
IA
T
S
MI
TEFS
S
T
R
Q
R
A
FSISFIA
--------
AM
W
Y
VG
ATC
A
D
L
VG
-
YWLYDVEGG
WRWML
G
SAAIP
C
LLI
LIG
R
F
EL
--------------------
PESPRWLLRKGR
V
K
E
C
E
EM
M
I
K
L
FG
EP
V
AFDE
EQ
PQQ
T
-
-
R
F
R
-----
--
--------------
D
LF
NR
R
HF
PFV
LF
VAAIWT
C
Q
--
VIP
M
F
A
IYT
F
G
P
Q
I
VGLL
GL
G
V
G
K
N
A
ALG
N
VVIS
L
FF
MLG
C
-----
I
PP
M
L
WL
N
TAG
RR
PL
L
I
GS
F
AM
M
TLA
LAVLG
L
IP
D
M
G
IW
--------
LVVM
A
F
A
-
VY
AF
F
S
GG
PG
NL
QW
LYP
N
ELFPTDIR
AS
A
VG
V
IM
S
LSRIG
T
I
VST
WA
LP
I
------
F
I
N
N
YG
-
I
S
N
TML
M
GA
G
I
S
L
F
GL
L
IS
VA
FAPETR
G
MSL
AQT
SN
M
TIRGQRMG
fig|536056.3.peg.3758
Escherichia coli DH1
MQPSRNFDDL
KF
S
SI
H
R
RI
LLWG
SG
GP
F
LDGYVL
VM
IGVAL
E
QLTPA
LK
L
DA
D
WI
G
LL
G
AGT
L
A
GLFVG
TS
LF
GYISD
KV
GRRK
M
F
L
ID
I
I
A
IGV
I
S
VATM
FV
SS
P
VE
L
L
VM
R
V
LIGI
V
IGADY
P
IA
T
S
MI
TEFS
S
T
R
Q
R
A
FSISFIA
--------
AM
W
Y
VG
ATC
A
D
L
VG
-
YWLYDVEGG
WRWML
G
SAAIP
C
LLI
LIG
R
F
EL
--------------------
PESPRWLLRKGR
V
K
E
C
E
EM
M
I
K
L
FG
EP
V
AFDE
EQ
PQQ
T
-
-
R
F
R
-----
--
--------------
D
LF
NR
R
HF
PFV
LF
VAAIWT
C
Q
--
VIP
M
F
A
IYT
F
G
P
Q
I
VGLL
GL
G
V
G
K
N
A
ALG
N
VVIS
L
FF
MLG
C
-----
I
PP
M
L
WL
N
TAG
RR
PL
L
I
GS
F
AM
M
TLA
LAVLG
L
IP
D
M
G
IW
--------
LVVM
A
F
A
-
VY
AF
F
S
GG
PG
NL
QW
LYP
N
ELFPTDIR
AS
A
VG
V
IM
S
LSRIG
T
I
VST
WA
LP
I
------
F
I
N
N
YG
-
I
S
N
TML
M
GA
G
I
S
L
F
GL
L
IS
VA
FAPETR
G
MSL
AQT
SN
M
TIRGQRMG
fig|340186.3.peg.4192
Escherichia coli E110019
MQPSRNFDDL
KF
S
SI
H
R
RI
LLWG
SG
GP
F
LDGYVL
VM
IGVAL
E
QLTPA
LK
L
DA
D
WI
G
LL
G
AGT
L
A
GLFVG
TS
LF
GYISD
KV
GRRK
M
F
L
ID
I
I
A
IGV
I
S
VATM
FV
SS
P
VE
L
L
VM
R
V
LIGI
V
IGADY
P
IA
T
S
MI
TEFS
S
T
R
Q
R
A
FSISFIA
--------
AM
W
Y
VG
ATC
A
D
L
VG
-
YWLYDVEGG
WRWML
G
SAAIP
C
LLI
LIG
R
F
EL
--------------------
PESPRWLLRKGR
V
K
E
C
E
EM
M
I
K
L
FG
EP
V
AFDE
EQ
PQQ
T
-
-
R
F
R
-----
--
--------------
D
LF
NR
R
HF
PFV
LF
VAAIWT
C
Q
--
VIP
M
F
A
IYT
F
G
P
Q
I
VGLL
GL
G
V
G
K
N
A
ALG
N
VVIS
L
FF
MLG
C
-----
I
PP
M
L
WL
N
TAG
RR
PL
L
I
GS
F
AM
M
TLA
LAVLG
L
IP
D
M
G
IW
--------
LVVM
A
F
A
-
VY
AF
F
S
GG
PG
NL
QW
LYP
N
ELFPTDIR
AS
A
VG
V
IM
S
LSRIG
T
I
VST
WA
LP
I
------
F
I
N
N
YG
-
I
S
N
TML
M
GA
G
I
S
L
F
GL
L
IS
VA
FAPETR
G
MSL
AQT
SN
M
TIRGQRMG
fig|340186.5.peg.4407
Escherichia coli E110019
MQPSRNFDDL
KF
S
SI
H
R
RI
LLWG
SG
GP
F
LDGYVL
VM
IGVAL
E
QLTPA
LK
L
DA
D
WI
G
LL
G
AGT
L
A
GLFVG
TS
LF
GYISD
KV
GRRK
M
F
L
ID
I
I
A
IGV
I
S
VATM
FV
SS
P
VE
L
L
VM
R
V
LIGI
V
IGADY
P
IA
T
S
MI
TEFS
S
T
R
Q
R
A
FSISFIA
--------
AM
W
Y
VG
ATC
A
D
L
VG
-
YWLYDVEGG
WRWML
G
SAAIP
C
LLI
LIG
R
F
EL
--------------------
PESPRWLLRKGR
V
K
E
C
E
EM
M
I
K
L
FG
EP
V
AFDE
EQ
PQQ
T
-
-
R
F
R
-----
--
--------------
D
LF
NR
R
HF
PFV
LF
VAAIWT
C
Q
--
VIP
M
F
A
IYT
F
G
P
Q
I
VGLL
GL
G
V
G
K
N
A
ALG
N
VVIS
L
FF
MLG
C
-----
I
PP
M
L
WL
N
TAG
RR
PL
L
I
GS
F
AM
M
TLA
LAVLG
L
IP
D
M
G
IW
--------
LVVM
A
F
A
-
VY
AF
F
S
GG
PG
NL
QW
LYP
N
ELFPTDIR
AS
A
VG
V
IM
S
LSRIG
T
I
VST
WA
LP
I
------
F
I
N
N
YG
-
I
S
N
TML
M
GA
G
I
S
L
F
GL
L
IS
VA
FAPETR
G
MSL
AQT
SN
M
TIRGQRMG
fig|340185.3.peg.4602
Escherichia coli E22
MQPSRNFDDL
KF
S
SI
H
R
RI
LLWG
SG
GP
F
LDGYVL
VM
IGVAL
E
QLTPA
LK
L
DA
D
WI
G
LL
G
AGT
L
A
GLFVG
TS
LF
GYISD
KV
GRRK
M
F
L
ID
I
I
A
IGV
I
S
VATM
FV
SS
P
VE
L
L
VM
R
V
LIGI
V
IGADY
P
IA
T
S
MI
TEFS
S
T
R
Q
R
A
FSISFIA
--------
AM
W
Y
VG
ATC
A
D
L
VG
-
YWLYDVEGG
WRWML
G
SAAIP
C
LLI
LIG
R
F
EL
--------------------
PESPRWLLRKGR
V
K
E
C
E
EM
M
I
K
L
FG
EP
V
AFDE
EQ
PQQ
T
-
-
R
F
R
-----
--
--------------
D
LF
NR
R
HF
PFV
LF
VAAIWT
C
Q
--
VIP
M
F
A
IYT
F
G
P
Q
I
VGLL
GL
G
V
G
K
N
A
ALG
N
VVIS
L
FF
MLG
C
-----
I
PP
M
L
WL
N
TAG
RR
PL
L
I
GS
F
AM
M
TLA
LAVLG
L
IP
D
M
G
IW
--------
LVVM
A
F
A
-
VY
AF
F
S
GG
PG
NL
QW
LYP
N
ELFPTDIR
AS
A
VG
V
IM
S
LSRIG
T
I
VST
WA
LP
I
------
F
I
N
N
YG
-
I
S
N
TML
M
GA
G
I
S
L
F
GL
L
IS
VA
FAPETR
G
MSL
AQT
SN
M
TIRGQRMG
fig|340185.4.peg.4850
Escherichia coli E22
MQPSRNFDDL
KF
S
SI
H
R
RI
LLWG
SG
GP
F
LDGYVL
VM
IGVAL
E
QLTPA
LK
L
DA
D
WI
G
LL
G
AGT
L
A
GLFVG
TS
LF
GYISD
KV
GRRK
M
F
L
ID
I
I
A
IGV
I
S
VATM
FV
SS
P
VE
L
L
VM
R
V
LIGI
V
IGADY
P
IA
T
S
MI
TEFS
S
T
R
Q
R
A
FSISFIA
--------
AM
W
Y
VG
ATC
A
D
L
VG
-
YWLYDVEGG
WRWML
G
SAAIP
C
LLI
LIG
R
F
EL
--------------------
PESPRWLLRKGR
V
K
E
C
E
EM
M
I
K
L
FG
EP
V
AFDE
EQ
PQQ
T
-
-
R
F
R
-----
--
--------------
D
LF
NR
R
HF
PFV
LF
VAAIWT
C
Q
--
VIP
M
F
A
IYT
F
G
P
Q
I
VGLL
GL
G
V
G
K
N
A
ALG
N
VVIS
L
FF
MLG
C
-----
I
PP
M
L
WL
N
TAG
RR
PL
L
I
GS
F
AM
M
TLA
LAVLG
L
IP
D
M
G
IW
--------
LVVM
A
F
A
-
VY
AF
F
S
GG
PG
NL
QW
LYP
N
ELFPTDIR
AS
A
VG
V
IM
S
LSRIG
T
I
VST
WA
LP
I
------
F
I
N
N
YG
-
I
S
N
TML
M
GA
G
I
S
L
F
GL
L
IS
VA
FAPETR
G
MSL
AQT
SN
M
TIRGQRMG
fig|562.375.peg.2613
Escherichia coli EC4100B
MQPSRNFDDL
KF
S
SI
H
R
RI
LLWG
SG
GP
F
LDGYVL
VM
IGVAL
E
QLTPA
LK
L
DA
D
WI
G
LL
G
AGT
L
A
GLFVG
TS
LF
GYISD
KV
GRRK
M
F
L
ID
I
I
A
IGV
I
S
VATM
FV
SS
P
VE
L
L
VM
R
V
LIGI
V
IGADY
P
IA
T
S
MI
TEFS
S
T
R
Q
R
A
FSISFIA
--------
AM
W
Y
VG
ATC
A
D
L
VG
-
YWLYDVEGG
WRWML
G
SAAIP
C
LLI
LIG
R
F
EL
--------------------
PESPRWLLRKGR
V
K
E
C
E
EM
M
I
K
L
FG
EP
V
AFDE
EQ
PQQ
T
-
-
R
F
R
-----
--
--------------
D
LF
NR
R
HF
PFV
LF
VAAIWT
C
Q
--
VIP
M
F
A
IYT
F
G
P
Q
I
VGLL
GL
G
V
G
K
N
A
ALG
N
VVIS
L
FF
MLG
C
-----
I
PP
M
L
WL
N
TAG
RR
PL
L
I
GS
F
AM
M
TLA
LAVLG
L
IP
D
M
G
IW
--------
LVVM
A
F
A
-
VY
AF
F
S
GG
PG
NL
QW
LYP
N
ELFPTDIR
AS
A
VG
V
IM
S
LSRIG
T
I
VST
WA
LP
I
------
F
I
N
N
YG
-
I
S
N
TML
M
GA
G
I
S
L
F
GL
L
IS
VA
FAPETR
G
MSL
AQT
SN
M
TIRGQRMG
fig|316401.4.peg.51
Escherichia coli ETEC H10407
MQPSRNFDDL
KF
S
SI
H
R
RI
LLWG
SG
GP
F
LDGYVL
VM
IGVAL
E
QLTPA
LK
L
DA
D
WI
G
LL
G
AGT
L
A
GLFVG
TS
LF
GYISD
KV
GRRK
M
F
L
ID
I
I
A
IGV
I
S
VATM
FV
SS
P
VE
L
L
VM
R
V
LIGI
V
IGADY
P
IA
T
S
MI
TEFS
S
T
R
Q
R
A
FSISFIA
--------
AM
W
Y
VG
ATC
A
D
L
VG
-
YWLYDVEGG
WRWML
G
SAAIP
C
LLI
LIG
R
F
EL
--------------------
PESPRWLLRKGR
V
K
E
C
E
EM
M
I
K
L
FG
EP
V
AFDE
EQ
PQQ
T
-
-
R
F
R
-----
--
--------------
D
LF
NR
R
HF
PFV
LF
VAAIWT
C
Q
--
VIP
M
F
A
IYT
F
G
P
Q
I
VGLL
GL
G
V
G
K
N
A
ALG
N
VVIS
L
FF
MLG
C
-----
I
PP
M
L
WL
N
TAG
RR
PL
L
I
GS
F
AM
M
TLA
LAVLG
L
IP
D
M
G
IW
--------
LVVM
A
F
A
-
VY
AF
F
S
GG
PG
NL
QW
LYP
N
ELFPTDIR
AS
A
VG
V
IM
S
LSRIG
T
I
VST
WA
LP
I
------
F
I
N
N
YG
-
I
S
N
TML
M
GA
G
I
S
L
F
GL
L
IS
VA
FAPETR
G
MSL
AQT
SN
M
TIRGQRMG
fig|340197.3.peg.4240
Escherichia coli F11
MQPSRNFDDL
KF
S
SI
H
R
RI
LLWG
SG
GP
F
LDGYVL
VM
IGVAL
E
QLTPA
LK
L
DA
D
WI
G
LL
G
AGT
L
A
GLFVG
TS
LF
GYISD
KV
GRRK
M
F
L
ID
I
I
A
IGV
I
S
VATM
FV
SS
P
VE
L
L
VM
R
V
LIGI
V
IGADY
P
IA
T
S
MI
TEFS
S
T
R
Q
R
A
FSISFIA
--------
AM
W
Y
VG
ATC
A
D
L
VG
-
YWLYDVEGG
WRWML
G
SAAIP
C
LLI
LIG
R
F
EL
--------------------
PESPRWLLRKGR
V
K
E
C
E
EM
M
I
K
L
FG
EP
V
AFDE
EQ
PQQ
T
-
-
R
F
R
-----
--
--------------
D
LF
NR
R
HF
PFV
LF
VAAIWT
C
Q
--
VIP
M
F
A
IYT
F
G
P
Q
I
VGLL
GL
G
V
G
K
N
A
ALG
N
VVIS
L
FF
MLG
C
-----
I
PP
M
L
WL
N
TAG
RR
PL
L
I
GS
F
AM
M
TLA
LAVLG
L
IP
D
M
G
IW
--------
LVVM
A
F
A
-
VY
AF
F
S
GG
PG
NL
QW
LYP
N
ELFPTDIR
AS
A
VG
V
IM
S
LSRIG
T
I
VST
WA
LP
I
------
F
I
N
N
YG
-
I
S
N
TML
M
GA
G
I
S
L
F
GL
L
IS
VA
FAPETR
G
MSL
AQT
SN
M
TIRGQRMG
fig|340197.5.peg.4424
Escherichia coli F11
MQPSRNFDDL
KF
S
SI
H
R
RI
LLWG
SG
GP
F
LDGYVL
VM
IGVAL
E
QLTPA
LK
L
DA
D
WI
G
LL
G
AGT
L
A
GLFVG
TS
LF
GYISD
KV
GRRK
M
F
L
ID
I
I
A
IGV
I
S
VATM
FV
SS
P
VE
L
L
VM
R
V
LIGI
V
IGADY
P
IA
T
S
MI
TEFS
S
T
R
Q
R
A
FSISFIA
--------
AM
W
Y
VG
ATC
A
D
L
VG
-
YWLYDVEGG
WRWML
G
SAAIP
C
LLI
LIG
R
F
EL
--------------------
PESPRWLLRKGR
V
K
E
C
E
EM
M
I
K
L
FG
EP
V
AFDE
EQ
PQQ
T
-
-
R
F
R
-----
--
--------------
D
LF
NR
R
HF
PFV
LF
VAAIWT
C
Q
--
VIP
M
F
A
IYT
F
G
P
Q
I
VGLL
GL
G
V
G
K
N
A
ALG
N
VVIS
L
FF
MLG
C
-----
I
PP
M
L
WL
N
TAG
RR
PL
L
I
GS
F
AM
M
TLA
LAVLG
L
IP
D
M
G
IW
--------
LVVM
A
F
A
-
VY
AF
F
S
GG
PG
NL
QW
LYP
N
ELFPTDIR
AS
A
VG
V
IM
S
LSRIG
T
I
VST
WA
LP
I
------
F
I
N
N
YG
-
I
S
N
TML
M
GA
G
I
S
L
F
GL
L
IS
VA
FAPETR
G
MSL
AQT
SN
M
TIRGQRMG
fig|656379.3.peg.285
Escherichia coli FVEC1302
MQPSRNFDDL
KF
S
SI
H
R
RI
LLWG
SG
GP
F
LDGYVL
VM
IGVAL
E
QLTPA
LK
L
DA
D
WI
G
LL
G
AGT
L
A
GLFVG
TS
LF
GYISD
KV
GRRK
M
F
L
ID
I
I
A
IGV
I
S
VATM
FV
SS
P
VE
L
L
VM
R
V
LIGI
V
IGADY
P
IA
T
S
MI
TEFS
S
T
R
Q
R
A
FSISFIA
--------
AM
W
Y
VG
ATC
A
D
L
VG
-
YWLYDVEGG
WRWML
G
SAAIP
C
LLI
LIG
R
F
EL
--------------------
PESPRWLLRKGR
V
K
E
C
E
EM
M
I
K
L
FG
EP
V
AFDE
EQ
PQQ
T
-
-
R
F
R
-----
--
--------------
D
LF
NR
R
HF
PFV
LF
VAAIWT
C
Q
--
VIP
M
F
A
IYT
F
G
P
Q
I
VGLL
GL
G
V
G
K
N
A
ALG
N
VVIS
L
FF
MLG
C
-----
I
PP
M
L
WL
N
TAG
RR
PL
L
I
GS
F
AM
M
TLA
LAVLG
L
IP
D
M
G
IW
--------
LVVM
A
F
A
-
VY
AF
F
S
GG
PG
NL
QW
LYP
N
ELFPTDIR
AS
A
VG
V
IM
S
LSRIG
T
I
VST
WA
LP
I
------
F
I
N
N
YG
-
I
S
N
TML
M
GA
G
I
S
L
F
GL
L
IS
VA
FAPETR
G
MSL
AQT
SN
M
TIRGQRMG
fig|656380.3.peg.222
Escherichia coli FVEC1412
MQPSRNFDDL
KF
S
SI
H
R
RI
LLWG
SG
GP
F
LDGYVL
VM
IGVAL
E
QLTPA
LK
L
DA
D
WI
G
LL
G
AGT
L
A
GLFVG
TS
LF
GYISD
KV
GRRK
M
F
L
ID
I
I
A
IGV
I
S
VATM
FV
SS
P
VE
L
L
VM
R
V
LIGI
V
IGADY
P
IA
T
S
MI
TEFS
S
T
R
Q
R
A
FSISFIA
--------
AM
W
Y
VG
ATC
A
D
L
VG
-
YWLYDVEGG
WRWML
G
SAAIP
C
LLI
LIG
R
F
EL
--------------------
PESPRWLLRKGR
V
K
E
C
E
EM
M
I
K
L
FG
EP
V
AFDE
EQ
PQQ
T
-
-
R
F
R
-----
--
--------------
D
LF
NR
R
HF
PFV
LF
VAAIWT
C
Q
--
VIP
M
F
A
IYT
F
G
P
Q
I
VGLL
GL
G
V
G
K
N
A
ALG
N
VVIS
L
FF
MLG
C
-----
I
PP
M
L
WL
N
TAG
RR
PL
L
I
GS
F
AM
M
TLA
LAVLG
L
IP
D
M
G
IW
--------
LVVM
A
F
A
-
VY
AF
F
S
GG
PG
NL
QW
LYP
N
ELFPTDIR
AS
A
VG
V
IM
S
LSRIG
T
I
VST
WA
LP
I
------
F
I
N
N
YG
-
I
S
N
TML
M
GA
G
I
S
L
F
GL
L
IS
VA
FAPETR
G
MSL
AQT
SN
M
TIRGQRMG
fig|656393.3.peg.656
Escherichia coli H299
MQPSRNFDDL
KF
S
SI
H
R
RI
LLWG
SG
GP
F
LDGYVL
VM
IGVAL
E
QLTPA
LK
L
DA
D
WI
G
LL
G
AGT
L
A
GLFVG
TS
LF
GYISD
KV
GRRK
M
F
L
ID
I
I
A
IGV
I
S
VATM
FV
SS
P
VE
L
L
VM
R
V
LIGI
V
IGADY
P
IA
T
S
MI
TEFS
S
T
R
Q
R
A
FSISFIA
--------
AM
W
Y
VG
ATC
A
D
L
VG
-
YWLYDVEGG
WRWML
G
SAAIP
C
LLI
LIG
R
F
EL
--------------------
PESPRWLLRKGR
V
K
E
C
E
EM
M
I
K
L
FG
EP
V
AFDE
EQ
PQQ
T
-
-
R
F
R
-----
--
--------------
D
LF
NR
R
HF
PFV
LF
VAAIWT
C
Q
--
VIP
M
F
A
IYT
F
G
P
Q
I
VGLL
GL
G
V
G
K
N
A
ALG
N
VVIS
L
FF
MLG
C
-----
I
PP
M
L
WL
N
TAG
RR
PL
L
I
GS
F
AM
M
TLA
LAVLG
L
IP
D
M
G
IW
--------
LVVM
A
F
A
-
VY
AF
F
S
GG
PG
NL
QW
LYP
N
ELFPTDIR
AS
A
VG
V
IM
S
LSRIG
T
I
VST
WA
LP
I
------
F
I
N
N
YG
-
I
S
N
TML
M
GA
G
I
S
L
F
GL
L
IS
VA
FAPETR
G
MSL
AQT
SN
M
TIRGQRMG
fig|656408.3.peg.4997
Escherichia coli H591
MQPSRNFDDL
KF
S
SI
H
R
RI
LLWG
SG
GP
F
LDGYVL
VM
IGVAL
E
QLTPA
LK
L
DA
D
WI
G
LL
G
AGT
L
A
GLFVG
TS
LF
GYISD
KV
GRRK
M
F
L
ID
I
I
A
IGV
I
S
VATM
FV
SS
P
VE
L
L
VM
R
V
LIGI
V
IGADY
P
IA
T
S
MI
TEFS
S
T
R
Q
R
A
FSISFIA
--------
AM
W
Y
VG
ATC
A
D
L
VG
-
YWLYDVEGG
WRWML
G
SAAIP
C
LLI
LIG
R
F
EL
--------------------
PESPRWLLRKGR
V
K
E
C
E
EM
M
I
K
L
FG
EP
V
AFDE
EQ
PQQ
T
-
-
R
F
R
-----
--
--------------
D
LF
NR
R
HF
PFV
LF
VAAIWT
C
Q
--
VIP
M
F
A
IYT
F
G
P
Q
I
VGLL
GL
G
V
G
K
N
A
ALG
N
VVIS
L
FF
MLG
C
-----
I
PP
M
L
WL
N
TAG
RR
PL
L
I
GS
F
AM
M
TLA
LAVLG
L
IP
D
M
G
IW
--------
LVVM
A
F
A
-
VY
AF
F
S
GG
PG
NL
QW
LYP
N
ELFPTDIR
AS
A
VG
V
IM
S
LSRIG
T
I
VST
WA
LP
I
------
F
I
N
N
YG
-
I
S
N
TML
M
GA
G
I
S
L
F
GL
L
IS
VA
FAPETR
G
MSL
AQT
SN
M
TIRGQRMG
fig|656414.3.peg.163
Escherichia coli H736
MQPSRNFDDL
KF
S
SI
H
R
RI
LLWG
SG
GP
F
LDGYVL
VM
IGVAL
E
QLTPA
LK
L
DA
D
WI
G
LL
G
AGT
L
A
GLFVG
TS
LF
GYISD
KV
GRRK
M
F
L
ID
I
I
A
IGV
I
S
VATM
FV
SS
P
VE
L
L
VM
R
V
LIGI
V
IGADY
P
IA
T
S
MI
TEFS
S
T
R
Q
R
A
FSISFIA
--------
AM
W
Y
VG
ATC
A
D
L
VG
-
YWLYDVEGG
WRWML
G
SAAIP
C
LLI
LIG
R
F
EL
--------------------
PESPRWLLRKGR
V
K
E
C
E
EM
M
I
K
L
FG
EP
V
AFDE
EQ
PQQ
T
-
-
R
F
R
-----
--
--------------
D
LF
NR
R
HF
PFV
LF
VAAIWT
C
Q
--
VIP
M
F
A
IYT
F
G
P
Q
I
VGLL
GL
G
V
G
K
N
A
ALG
N
VVIS
L
FF
MLG
C
-----
I
PP
M
L
WL
N
TAG
RR
PL
L
I
GS
F
AM
M
TLA
LAVLG
L
IP
D
M
G
IW
--------
LVVM
A
F
A
-
VY
AF
F
S
GG
PG
NL
QW
LYP
N
ELFPTDIR
AS
A
VG
V
IM
S
LSRIG
T
I
VST
WA
LP
I
------
F
I
N
N
YG
-
I
S
N
TML
M
GA
G
I
S
L
F
GL
L
IS
VA
FAPETR
G
MSL
AQT
SN
M
TIRGQRMG
fig|331112.3.peg.47
Escherichia coli HS
MQPSRNFDDL
KF
S
SI
H
R
RI
LLWG
SG
GP
F
LDGYVL
VM
IGVAL
E
QLTPA
LK
L
DA
D
WI
G
LL
G
AGT
L
A
GLFVG
TS
LF
GYISD
KV
GRRK
M
F
L
ID
I
I
A
IGV
I
S
VATM
FV
SS
P
VE
L
L
VM
R
V
LIGI
V
IGADY
P
IA
T
S
MI
TEFS
S
T
R
Q
R
A
FSISFIA
--------
AM
W
Y
VG
ATC
A
D
L
VG
-
YWLYDVEGG
WRWML
G
SAAIP
C
LLI
LIG
R
F
EL
--------------------
PESPRWLLRKGR
V
K
E
C
E
EM
M
I
K
L
FG
EP
V
AFDE
EQ
PQQ
T
-
-
R
F
R
-----
--
--------------
D
LF
NR
R
HF
PFV
LF
VAAIWT
C
Q
--
VIP
M
F
A
IYT
F
G
P
Q
I
VGLL
GL
G
V
G
K
N
A
ALG
N
VVIS
L
FF
MLG
C
-----
I
PP
M
L
WL
N
TAG
RR
PL
L
I
GS
F
AM
M
TLA
LAVLG
L
IP
D
M
G
IW
--------
LVVM
A
F
A
-
VY
AF
F
S
GG
PG
NL
QW
LYP
N
ELFPTDIR
AS
A
VG
V
IM
S
LSRIG
T
I
VST
WA
LP
I
------
F
I
N
N
YG
-
I
S
N
TML
M
GA
G
I
S
L
F
GL
L
IS
VA
FAPETR
G
MSL
AQT
SN
M
TIRGQRMG
fig|331112.6.peg.50
Escherichia coli HS
MQPSRNFDDL
KF
S
SI
H
R
RI
LLWG
SG
GP
F
LDGYVL
VM
IGVAL
E
QLTPA
LK
L
DA
D
WI
G
LL
G
AGT
L
A
GLFVG
TS
LF
GYISD
KV
GRRK
M
F
L
ID
I
I
A
IGV
I
S
VATM
FV
SS
P
VE
L
L
VM
R
V
LIGI
V
IGADY
P
IA
T
S
MI
TEFS
S
T
R
Q
R
A
FSISFIA
--------
AM
W
Y
VG
ATC
A
D
L
VG
-
YWLYDVEGG
WRWML
G
SAAIP
C
LLI
LIG
R
F
EL
--------------------
PESPRWLLRKGR
V
K
E
C
E
EM
M
I
K
L
FG
EP
V
AFDE
EQ
PQQ
T
-
-
R
F
R
-----
--
--------------
D
LF
NR
R
HF
PFV
LF
VAAIWT
C
Q
--
VIP
M
F
A
IYT
F
G
P
Q
I
VGLL
GL
G
V
G
K
N
A
ALG
N
VVIS
L
FF
MLG
C
-----
I
PP
M
L
WL
N
TAG
RR
PL
L
I
GS
F
AM
M
TLA
LAVLG
L
IP
D
M
G
IW
--------
LVVM
A
F
A
-
VY
AF
F
S
GG
PG
NL
QW
LYP
N
ELFPTDIR
AS
A
VG
V
IM
S
LSRIG
T
I
VST
WA
LP
I
------
F
I
N
N
YG
-
I
S
N
TML
M
GA
G
I
S
L
F
GL
L
IS
VA
FAPETR
G
MSL
AQT
SN
M
TIRGQRMG
fig|585034.4.peg.47
Escherichia coli IAI1
MQPSRNFDDL
KF
S
SI
H
R
RI
LLWG
SG
GP
F
LDGYVL
VM
IGVAL
E
QLTPA
LK
L
DA
D
WI
G
LL
G
AGT
L
A
GLFVG
TS
LF
GYISD
KV
GRRK
M
F
L
ID
I
I
A
IGV
I
S
VATM
FV
SS
P
VE
L
L
VM
R
V
LIGI
V
IGADY
P
IA
T
S
MI
TEFS
S
T
R
Q
R
A
FSISFIA
--------
AM
W
Y
VG
ATC
A
D
L
VG
-
YWLYDVEGG
WRWML
G
SAAIP
C
LLI
LIG
R
F
EL
--------------------
PESPRWLLRKGR
V
K
E
C
E
EM
M
I
K
L
FG
EP
V
AFDE
EQ
PQQ
T
-
-
R
F
R
-----
--
--------------
D
LF
NR
R
HF
PFV
LF
VAAIWT
C
Q
--
VIP
M
F
A
IYT
F
G
P
Q
I
VGLL
GL
G
V
G
K
N
A
ALG
N
VVIS
L
FF
MLG
C
-----
I
PP
M
L
WL
N
TAG
RR
PL
L
I
GS
F
AM
M
TLA
LAVLG
L
IP
D
M
G
IW
--------
LVVM
A
F
A
-
VY
AF
F
S
GG
PG
NL
QW
LYP
N
ELFPTDIR
AS
A
VG
V
IM
S
LSRIG
T
I
VST
WA
LP
I
------
F
I
N
N
YG
-
I
S
N
TML
M
GA
G
I
S
L
F
GL
L
IS
VA
FAPETR
G
MSL
AQT
SN
M
TIRGQRMG
fig|585034.5.peg.47
Escherichia coli IAI1
MQPSRNFDDL
KF
S
SI
H
R
RI
LLWG
SG
GP
F
LDGYVL
VM
IGVAL
E
QLTPA
LK
L
DA
D
WI
G
LL
G
AGT
L
A
GLFVG
TS
LF
GYISD
KV
GRRK
M
F
L
ID
I
I
A
IGV
I
S
VATM
FV
SS
P
VE
L
L
VM
R
V
LIGI
V
IGADY
P
IA
T
S
MI
TEFS
S
T
R
Q
R
A
FSISFIA
--------
AM
W
Y
VG
ATC
A
D
L
VG
-
YWLYDVEGG
WRWML
G
SAAIP
C
LLI
LIG
R
F
EL
--------------------
PESPRWLLRKGR
V
K
E
C
E
EM
M
I
K
L
FG
EP
V
AFDE
EQ
PQQ
T
-
-
R
F
R
-----
--
--------------
D
LF
NR
R
HF
PFV
LF
VAAIWT
C
Q
--
VIP
M
F
A
IYT
F
G
P
Q
I
VGLL
GL
G
V
G
K
N
A
ALG
N
VVIS
L
FF
MLG
C
-----
I
PP
M
L
WL
N
TAG
RR
PL
L
I
GS
F
AM
M
TLA
LAVLG
L
IP
D
M
G
IW
--------
LVVM
A
F
A
-
VY
AF
F
S
GG
PG
NL
QW
LYP
N
ELFPTDIR
AS
A
VG
V
IM
S
LSRIG
T
I
VST
WA
LP
I
------
F
I
N
N
YG
-
I
S
N
TML
M
GA
G
I
S
L
F
GL
L
IS
VA
FAPETR
G
MSL
AQT
SN
M
TIRGQRMG
fig|83333.1.peg.46
Escherichia coli K12
MQPSRNFDDL
KF
S
SI
H
R
RI
LLWG
SG
GP
F
LDGYVL
VM
IGVAL
E
QLTPA
LK
L
DA
D
WI
G
LL
G
AGT
L
A
GLFVG
TS
LF
GYISD
KV
GRRK
M
F
L
ID
I
I
A
IGV
I
S
VATM
FV
SS
P
VE
L
L
VM
R
V
LIGI
V
IGADY
P
IA
T
S
MI
TEFS
S
T
R
Q
R
A
FSISFIA
--------
AM
W
Y
VG
ATC
A
D
L
VG
-
YWLYDVEGG
WRWML
G
SAAIP
C
LLI
LIG
R
F
EL
--------------------
PESPRWLLRKGR
V
K
E
C
E
EM
M
I
K
L
FG
EP
V
AFDE
EQ
PQQ
T
-
-
R
F
R
-----
--
--------------
D
LF
NR
R
HF
PFV
LF
VAAIWT
C
Q
--
VIP
M
F
A
IYT
F
G
P
Q
I
VGLL
GL
G
V
G
K
N
A
ALG
N
VVIS
L
FF
MLG
C
-----
I
PP
M
L
WL
N
TAG
RR
PL
L
I
GS
F
AM
M
TLA
LAVLG
L
IP
D
M
G
IW
--------
LVVM
A
F
A
-
VY
AF
F
S
GG
PG
NL
QW
LYP
N
ELFPTDIR
AS
A
VG
V
IM
S
LSRIG
T
I
VST
WA
LP
I
------
F
I
N
N
YG
-
I
S
N
TML
M
GA
G
I
S
L
F
GL
L
IS
VA
FAPETR
G
MSL
AQT
SN
M
TIRGQRMG
fig|595495.4.peg.1681
Escherichia coli KO11
MQPSRNFDDL
KF
S
SI
H
R
RI
LLWG
SG
GP
F
LDGYVL
VM
IGVAL
E
QLTPA
LK
L
DA
D
WI
G
LL
G
AGT
L
A
GLFVG
TS
LF
GYISD
KV
GRRK
M
F
L
ID
I
I
A
IGV
I
S
VATM
FV
SS
P
VE
L
L
VM
R
V
LIGI
V
IGADY
P
IA
T
S
MI
TEFS
S
T
R
Q
R
A
FSISFIA
--------
AM
W
Y
VG
ATC
A
D
L
VG
-
YWLYDVEGG
WRWML
G
SAAIP
C
LLI
LIG
R
F
EL
--------------------
PESPRWLLRKGR
V
K
E
C
E
EM
M
I
K
L
FG
EP
V
AFDE
EQ
PQQ
T
-
-
R
F
R
-----
--
--------------
D
LF
NR
R
HF
PFV
LF
VAAIWT
C
Q
--
VIP
M
F
A
IYT
F
G
P
Q
I
VGLL
GL
G
V
G
K
N
A
ALG
N
VVIS
L
FF
MLG
C
-----
I
PP
M
L
WL
N
TAG
RR
PL
L
I
GS
F
AM
M
TLA
LAVLG
L
IP
D
M
G
IW
--------
LVVM
A
F
A
-
VY
AF
F
S
GG
PG
NL
QW
LYP
N
ELFPTDIR
AS
A
VG
V
IM
S
LSRIG
T
I
VST
WA
LP
I
------
F
I
N
N
YG
-
I
S
N
TML
M
GA
G
I
S
L
F
GL
L
IS
VA
FAPETR
G
MSL
AQT
SN
M
TIRGQRMG
fig|656419.3.peg.201
Escherichia coli M718
MQPSRNFDDL
KF
S
SI
H
R
RI
LLWG
SG
GP
F
LDGYVL
VM
IGVAL
E
QLTPA
LK
L
DA
D
WI
G
LL
G
AGT
L
A
GLFVG
TS
LF
GYISD
KV
GRRK
M
F
L
ID
I
I
A
IGV
I
S
VATM
FV
SS
P
VE
L
L
VM
R
V
LIGI
V
IGADY
P
IA
T
S
MI
TEFS
S
T
R
Q
R
A
FSISFIA
--------
AM
W
Y
VG
ATC
A
D
L
VG
-
YWLYDVEGG
WRWML
G
SAAIP
C
LLI
LIG
R
F
EL
--------------------
PESPRWLLRKGR
V
K
E
C
E
EM
M
I
K
L
FG
EP
V
AFDE
EQ
PQQ
T
-
-
R
F
R
-----
--
--------------
D
LF
NR
R
HF
PFV
LF
VAAIWT
C
Q
--
VIP
M
F
A
IYT
F
G
P
Q
I
VGLL
GL
G
V
G
K
N
A
ALG
N
VVIS
L
FF
MLG
C
-----
I
PP
M
L
WL
N
TAG
RR
PL
L
I
GS
F
AM
M
TLA
LAVLG
L
IP
D
M
G
IW
--------
LVVM
A
F
A
-
VY
AF
F
S
GG
PG
NL
QW
LYP
N
ELFPTDIR
AS
A
VG
V
IM
S
LSRIG
T
I
VST
WA
LP
I
------
F
I
N
N
YG
-
I
S
N
TML
M
GA
G
I
S
L
F
GL
L
IS
VA
FAPETR
G
MSL
AQT
SN
M
TIRGQRMG
fig|679207.4.peg.1082
Escherichia coli MS 107-1
MQPSRNFDDL
KF
S
SI
H
R
RI
LLWG
SG
GP
F
LDGYVL
VM
IGVAL
E
QLTPA
LK
L
DA
D
WI
G
LL
G
AGT
L
A
GLFVG
TS
LF
GYISD
KV
GRRK
M
F
L
ID
I
I
A
IGV
I
S
VATM
FV
SS
P
VE
L
L
VM
R
V
LIGI
V
IGADY
P
IA
T
S
MI
TEFS
S
T
R
Q
R
A
FSISFIA
--------
AM
W
Y
VG
ATC
A
D
L
VG
-
YWLYDVEGG
WRWML
G
SAAIP
C
LLI
LIG
R
F
EL
--------------------
PESPRWLLRKGR
V
K
E
C
E
EM
M
I
K
L
FG
EP
V
AFDE
EQ
PQQ
T
-
-
R
F
R
-----
--
--------------
D
LF
NR
R
HF
PFV
LF
VAAIWT
C
Q
--
VIP
M
F
A
IYT
F
G
P
Q
I
VGLL
GL
G
V
G
K
N
A
ALG
N
VVIS
L
FF
MLG
C
-----
I
PP
M
L
WL
N
TAG
RR
PL
L
I
GS
F
AM
M
TLA
LAVLG
L
IP
D
M
G
IW
--------
LVVM
A
F
A
-
VY
AF
F
S
GG
PG
NL
QW
LYP
N
ELFPTDIR
AS
A
VG
V
IM
S
LSRIG
T
I
VST
WA
LP
I
------
F
I
N
N
YG
-
I
S
N
TML
M
GA
G
I
S
L
F
GL
L
IS
VA
FAPETR
G
MSL
AQT
SN
M
TIRGQRMG
fig|749537.3.peg.3137
Escherichia coli MS 115-1
MQPSRNFDDL
KF
S
SI
H
R
RI
LLWG
SG
GP
F
LDGYVL
VM
IGVAL
E
QLTPA
LK
L
DA
D
WI
G
LL
G
AGT
L
A
GLFVG
TS
LF
GYISD
KV
GRRK
M
F
L
ID
I
I
A
IGV
I
S
VATM
FV
SS
P
VE
L
L
VM
R
V
LIGI
V
IGADY
P
IA
T
S
MI
TEFS
S
T
R
Q
R
A
FSISFIA
--------
AM
W
Y
VG
ATC
A
D
L
VG
-
YWLYDVEGG
WRWML
G
SAAIP
C
LLI
LIG
R
F
EL
--------------------
PESPRWLLRKGR
V
K
E
C
E
EM
M
I
K
L
FG
EP
V
AFDE
EQ
PQQ
T
-
-
R
F
R
-----
--
--------------
D
LF
NR
R
HF
PFV
LF
VAAIWT
C
Q
--
VIP
M
F
A
IYT
F
G
P
Q
I
VGLL
GL
G
V
G
K
N
A
ALG
N
VVIS
L
FF
MLG
C
-----
I
PP
M
L
WL
N
TAG
RR
PL
L
I
GS
F
AM
M
TLA
LAVLG
L
IP
D
M
G
IW
--------
LVVM
A
F
A
-
VY
AF
F
S
GG
PG
NL
QW
LYP
N
ELFPTDIR
AS
A
VG
V
IM
S
LSRIG
T
I
VST
WA
LP
I
------
F
I
N
N
YG
-
I
S
N
TML
M
GA
G
I
S
L
F
GL
L
IS
VA
FAPETR
G
MSL
AQT
SN
M
TIRGQRMG
fig|749538.3.peg.2053
Escherichia coli MS 116-1
MQPSRNFDDL
KF
S
SI
H
R
RI
LLWG
SG
GP
F
LDGYVL
VM
IGVAL
E
QLTPA
LK
L
DA
D
WI
G
LL
G
AGT
L
A
GLFVG
TS
LF
GYISD
KV
GRRK
M
F
L
ID
I
I
A
IGV
I
S
VATM
FV
SS
P
VE
L
L
VM
R
V
LIGI
V
IGADY
P
IA
T
S
MI
TEFS
S
T
R
Q
R
A
FSISFIA
--------
AM
W
Y
VG
ATC
A
D
L
VG
-
YWLYDVEGG
WRWML
G
SAAIP
C
LLI
LIG
R
F
EL
--------------------
PESPRWLLRKGR
V
K
E
C
E
EM
M
I
K
L
FG
EP
V
AFDE
EQ
PQQ
T
-
-
R
F
R
-----
--
--------------
D
LF
NR
R
HF
PFV
LF
VAAIWT
C
Q
--
VIP
M
F
A
IYT
F
G
P
Q
I
VGLL
GL
G
V
G
K
N
A
ALG
N
VVIS
L
FF
MLG
C
-----
I
PP
M
L
WL
N
TAG
RR
PL
L
I
GS
F
AM
M
TLA
LAVLG
L
IP
D
M
G
IW
--------
LVVM
A
F
A
-
VY
AF
F
S
GG
PG
NL
QW
LYP
N
ELFPTDIR
AS
A
VG
V
IM
S
LSRIG
T
I
VST
WA
LP
I
------
F
I
N
N
YG
-
I
S
N
TML
M
GA
G
I
S
L
F
GL
L
IS
VA
FAPETR
G
MSL
AQT
SN
M
TIRGQRMG
fig|679206.4.peg.1728
Escherichia coli MS 119-7
MQPSRNFDDL
KF
S
SI
H
R
RI
LLWG
SG
GP
F
LDGYVL
VM
IGVAL
E
QLTPA
LK
L
DA
D
WI
G
LL
G
AGT
L
A
GLFVG
TS
LF
GYISD
KV
GRRK
M
F
L
ID
I
I
A
IGV
I
S
VATM
FV
SS
P
VE
L
L
VM
R
V
LIGI
V
IGADY
P
IA
T
S
MI
TEFS
S
T
R
Q
R
A
FSISFIA
--------
AM
W
Y
VG
ATC
A
D
L
VG
-
YWLYDVEGG
WRWML
G
SAAIP
C
LLI
LIG
R
F
EL
--------------------
PESPRWLLRKGR
V
K
E
C
E
EM
M
I
K
L
FG
EP
V
AFDE
EQ
PQQ
T
-
-
R
F
R
-----
--
--------------
D
LF
NR
R
HF
PFV
LF
VAAIWT
C
Q
--
VIP
M
F
A
IYT
F
G
P
Q
I
VGLL
GL
G
V
G
K
N
A
ALG
N
VVIS
L
FF
MLG
C
-----
I
PP
M
L
WL
N
TAG
RR
PL
L
I
GS
F
AM
M
TLA
LAVLG
L
IP
D
M
G
IW
--------
LVVM
A
F
A
-
VY
AF
F
S
GG
PG
NL
QW
LYP
N
ELFPTDIR
AS
A
VG
V
IM
S
LSRIG
T
I
VST
WA
LP
I
------
F
I
N
N
YG
-
I
S
N
TML
M
GA
G
I
S
L
F
GL
L
IS
VA
FAPETR
G
MSL
AQT
SN
M
TIRGQRMG
fig|679205.4.peg.3541
Escherichia coli MS 124-1
MQPSRNFDDL
KF
S
SI
H
R
RI
LLWG
SG
GP
F
LDGYVL
VM
IGVAL
E
QLTPA
LK
L
DA
D
WI
G
LL
G
AGT
L
A
GLFVG
TS
LF
GYISD
KV
GRRK
M
F
L
ID
I
I
A
IGV
I
S
VATM
FV
SS
P
VE
L
L
VM
R
V
LIGI
V
IGADY
P
IA
T
S
MI
TEFS
S
T
R
Q
R
A
FSISFIA
--------
AM
W
Y
VG
ATC
A
D
L
VG
-
YWLYDVEGG
WRWML
G
SAAIP
C
LLI
LIG
R
F
EL
--------------------
PESPRWLLRKGR
V
K
E
C
E
EM
M
I
K
L
FG
EP
V
AFDE
EQ
PQQ
T
-
-
R
F
R
-----
--
--------------
D
LF
NR
R
HF
PFV
LF
VAAIWT
C
Q
--
VIP
M
F
A
IYT
F
G
P
Q
I
VGLL
GL
G
V
G
K
N
A
ALG
N
VVIS
L
FF
MLG
C
-----
I
PP
M
L
WL
N
TAG
RR
PL
L
I
GS
F
AM
M
TLA
LAVLG
L
IP
D
M
G
IW
--------
LVVM
A
F
A
-
VY
AF
F
S
GG
PG
NL
QW
LYP
N
ELFPTDIR
AS
A
VG
V
IM
S
LSRIG
T
I
VST
WA
LP
I
------
F
I
N
N
YG
-
I
S
N
TML
M
GA
G
I
S
L
F
GL
L
IS
VA
FAPETR
G
MSL
AQT
SN
M
TIRGQRMG
fig|679204.3.peg.3155
Escherichia coli MS 145-7
MQPSRNFDDL
KF
S
SI
H
R
RI
LLWG
SG
GP
F
LDGYVL
VM
IGVAL
E
QLTPA
LK
L
DA
D
WI
G
LL
G
AGT
L
A
GLFVG
TS
LF
GYISD
KV
GRRK
M
F
L
ID
I
I
A
IGV
I
S
VATM
FV
SS
P
VE
L
L
VM
R
V
LIGI
V
IGADY
P
IA
T
S
MI
TEFS
S
T
R
Q
R
A
FSISFIA
--------
AM
W
Y
VG
ATC
A
D
L
VG
-
YWLYDVEGG
WRWML
G
SAAIP
C
LLI
LIG
R
F
EL
--------------------
PESPRWLLRKGR
V
K
E
C
E
EM
M
I
K
L
FG
EP
V
AFDE
EQ
PQQ
T
-
-
R
F
R
-----
--
--------------
D
LF
NR
R
HF
PFV
LF
VAAIWT
C
Q
--
VIP
M
F
A
IYT
F
G
P
Q
I
VGLL
GL
G
V
G
K
N
A
ALG
N
VVIS
L
FF
MLG
C
-----
I
PP
M
L
WL
N
TAG
RR
PL
L
I
GS
F
AM
M
TLA
LAVLG
L
IP
D
M
G
IW
--------
LVVM
A
F
A
-
VY
AF
F
S
GG
PG
NL
QW
LYP
N
ELFPTDIR
AS
A
VG
V
IM
S
LSRIG
T
I
VST
WA
LP
I
------
F
I
N
N
YG
-
I
S
N
TML
M
GA
G
I
S
L
F
GL
L
IS
VA
FAPETR
G
MSL
AQT
SN
M
TIRGQRMG
fig|749540.3.peg.4662
Escherichia coli MS 146-1
MQPSRNFDDL
KF
S
SI
H
R
RI
LLWG
SG
GP
F
LDGYVL
VM
IGVAL
E
QLTPA
LK
L
DA
D
WI
G
LL
G
AGT
L
A
GLFVG
TS
LF
GYISD
KV
GRRK
M
F
L
ID
I
I
A
IGV
I
S
VATM
FV
SS
P
VE
L
L
VM
R
V
LIGI
V
IGADY
P
IA
T
S
MI
TEFS
S
T
R
Q
R
A
FSISFIA
--------
AM
W
Y
VG
ATC
A
D
L
VG
-
YWLYDVEGG
WRWML
G
SAAIP
C
LLI
LIG
R
F
EL
--------------------
PESPRWLLRKGR
V
K
E
C
E
EM
M
I
K
L
FG
EP
V
AFDE
EQ
PQQ
T
-
-
R
F
R
-----
--
--------------
D
LF
NR
R
HF
PFV
LF
VAAIWT
C
Q
--
VIP
M
F
A
IYT
F
G
P
Q
I
VGLL
GL
G
V
G
K
N
A
ALG
N
VVIS
L
FF
MLG
C
-----
I
PP
M
L
WL
N
TAG
RR
PL
L
I
GS
F
AM
M
TLA
LAVLG
L
IP
D
M
G
IW
--------
LVVM
A
F
A
-
VY
AF
F
S
GG
PG
NL
QW
LYP
N
ELFPTDIR
AS
A
VG
V
IM
S
LSRIG
T
I
VST
WA
LP
I
------
F
I
N
N
YG
-
I
S
N
TML
M
GA
G
I
S
L
F
GL
L
IS
VA
FAPETR
G
MSL
AQT
SN
M
TIRGQRMG
fig|749544.3.peg.2663
Escherichia coli MS 175-1
MQPSRNFDDL
KF
S
SI
H
R
RI
LLWG
SG
GP
F
LDGYVL
VM
IGVAL
E
QLTPA
LK
L
DA
D
WI
G
LL
G
AGT
L
A
GLFVG
TS
LF
GYISD
KV
GRRK
M
F
L
ID
I
I
A
IGV
I
S
VATM
FV
SS
P
VE
L
L
VM
R
V
LIGI
V
IGADY
P
IA
T
S
MI
TEFS
S
T
R
Q
R
A
FSISFIA
--------
AM
W
Y
VG
ATC
A
D
L
VG
-
YWLYDVEGG
WRWML
G
SAAIP
C
LLI
LIG
R
F
EL
--------------------
PESPRWLLRKGR
V
K
E
C
E
EM
M
I
K
L
FG
EP
V
AFDE
EQ
PQQ
T
-
-
R
F
R
-----
--
--------------
D
LF
NR
R
HF
PFV
LF
VAAIWT
C
Q
--
VIP
M
F
A
IYT
F
G
P
Q
I
VGLL
GL
G
V
G
K
N
A
ALG
N
VVIS
L
FF
MLG
C
-----
I
PP
M
L
WL
N
TAG
RR
PL
L
I
GS
F
AM
M
TLA
LAVLG
L
IP
D
M
G
IW
--------
LVVM
A
F
A
-
VY
AF
F
S
GG
PG
NL
QW
LYP
N
ELFPTDIR
AS
A
VG
V
IM
S
LSRIG
T
I
VST
WA
LP
I
------
F
I
N
N
YG
-
I
S
N
TML
M
GA
G
I
S
L
F
GL
L
IS
VA
FAPETR
G
MSL
AQT
SN
M
TIRGQRMG
fig|749545.3.peg.2063
Escherichia coli MS 182-1
MQPSRNFDDL
KF
S
SI
H
R
RI
LLWG
SG
GP
F
LDGYVL
VM
IGVAL
E
QLTPA
LK
L
DA
D
WI
G
LL
G
AGT
L
A
GLFVG
TS
LF
GYISD
KV
GRRK
M
F
L
ID
I
I
A
IGV
I
S
VATM
FV
SS
P
VE
L
L
VM
R
V
LIGI
V
IGADY
P
IA
T
S
MI
TEFS
S
T
R
Q
R
A
FSISFIA
--------
AM
W
Y
VG
ATC
A
D
L
VG
-
YWLYDVEGG
WRWML
G
SAAIP
C
LLI
LIG
R
F
EL
--------------------
PESPRWLLRKGR
V
K
E
C
E
EM
M
I
K
L
FG
EP
V
AFDE
EQ
PQQ
T
-
-
R
F
R
-----
--
--------------
D
LF
NR
R
HF
PFV
LF
VAAIWT
C
Q
--
VIP
M
F
A
IYT
F
G
P
Q
I
VGLL
GL
G
V
G
K
N
A
ALG
N
VVIS
L
FF
MLG
C
-----
I
PP
M
L
WL
N
TAG
RR
PL
L
I
GS
F
AM
M
TLA
LAVLG
L
IP
D
M
G
IW
--------
LVVM
A
F
A
-
VY
AF
F
S
GG
PG
NL
QW
LYP
N
ELFPTDIR
AS
A
VG
V
IM
S
LSRIG
T
I
VST
WA
LP
I
------
F
I
N
N
YG
-
I
S
N
TML
M
GA
G
I
S
L
F
GL
L
IS
VA
FAPETR
G
MSL
AQT
SN
M
TIRGQRMG
fig|749547.3.peg.979
Escherichia coli MS 187-1
MQPSRNFDDL
KF
S
SI
H
R
RI
LLWG
SG
GP
F
LDGYVL
VM
IGVAL
E
QLTPA
LK
L
DA
D
WI
G
LL
G
AGT
L
A
GLFVG
TS
LF
GYISD
KV
GRRK
M
F
L
ID
I
I
A
IGV
I
S
VATM
FV
SS
P
VE
L
L
VM
R
V
LIGI
V
IGADY
P
IA
T
S
MI
TEFS
S
T
R
Q
R
A
FSISFIA
--------
AM
W
Y
VG
ATC
A
D
L
VG
-
YWLYDVEGG
WRWML
G
SAAIP
C
LLI
LIG
R
F
EL
--------------------
PESPRWLLRKGR
V
K
E
C
E
EM
M
I
K
L
FG
EP
V
AFDE
EQ
PQQ
T
-
-
R
F
R
-----
--
--------------
D
LF
NR
R
HF
PFV
LF
VAAIWT
C
Q
--
VIP
M
F
A
IYT
F
G
P
Q
I
VGLL
GL
G
V
G
K
N
A
ALG
N
VVIS
L
FF
MLG
C
-----
I
PP
M
L
WL
N
TAG
RR
PL
L
I
GS
F
AM
M
TLA
LAVLG
L
IP
D
M
G
IW
--------
LVVM
A
F
A
-
VY
AF
F
S
GG
PG
NL
QW
LYP
N
ELFPTDIR
AS
A
VG
V
IM
S
LSRIG
T
I
VST
WA
LP
I
------
F
I
N
N
YG
-
I
S
N
TML
M
GA
G
I
S
L
F
GL
L
IS
VA
FAPETR
G
MSL
AQT
SN
M
TIRGQRMG
fig|749548.3.peg.2393
Escherichia coli MS 196-1
MQPSRNFDDL
KF
S
SI
H
R
RI
LLWG
SG
GP
F
LDGYVL
VM
IGVAL
E
QLTPA
LK
L
DA
D
WI
G
LL
G
AGT
L
A
GLFVG
TS
LF
GYISD
KV
GRRK
M
F
L
ID
I
I
A
IGV
I
S
VATM
FV
SS
P
VE
L
L
VM
R
V
LIGI
V
IGADY
P
IA
T
S
MI
TEFS
S
T
R
Q
R
A
FSISFIA
--------
AM
W
Y
VG
ATC
A
D
L
VG
-
YWLYDVEGG
WRWML
G
SAAIP
C
LLI
LIG
R
F
EL
--------------------
PESPRWLLRKGR
V
K
E
C
E
EM
M
I
K
L
FG
EP
V
AFDE
EQ
PQQ
T
-
-
R
F
R
-----
--
--------------
D
LF
NR
R
HF
PFV
LF
VAAIWT
C
Q
--
VIP
M
F
A
IYT
F
G
P
Q
I
VGLL
GL
G
V
G
K
N
A
ALG
N
VVIS
L
FF
MLG
C
-----
I
PP
M
L
WL
N
TAG
RR
PL
L
I
GS
F
AM
M
TLA
LAVLG
L
IP
D
M
G
IW
--------
LVVM
A
F
A
-
VY
AF
F
S
GG
PG
NL
QW
LYP
N
ELFPTDIR
AS
A
VG
V
IM
S
LSRIG
T
I
VST
WA
LP
I
------
F
I
N
N
YG
-
I
S
N
TML
M
GA
G
I
S
L
F
GL
L
IS
VA
FAPETR
G
MSL
AQT
SN
M
TIRGQRMG
fig|749549.3.peg.4607
Escherichia coli MS 198-1
MQPSRNFDDL
KF
S
SI
H
R
RI
LLWG
SG
GP
F
LDGYVL
VM
IGVAL
E
QLTPA
LK
L
DA
D
WI
G
LL
G
AGT
L
A
GLFVG
TS
LF
GYISD
KV
GRRK
M
F
L
ID
I
I
A
IGV
I
S
VATM
FV
SS
P
VE
L
L
VM
R
V
LIGI
V
IGADY
P
IA
T
S
MI
TEFS
S
T
R
Q
R
A
FSISFIA
--------
AM
W
Y
VG
ATC
A
D
L
VG
-
YWLYDVEGG
WRWML
G
SAAIP
C
LLI
LIG
R
F
EL
--------------------
PESPRWLLRKGR
V
K
E
C
E
EM
M
I
K
L
FG
EP
V
AFDE
EQ
PQQ
T
-
-
R
F
R
-----
--
--------------
D
LF
NR
R
HF
PFV
LF
VAAIWT
C
Q
--
VIP
M
F
A
IYT
F
G
P
Q
I
VGLL
GL
G
V
G
K
N
A
ALG
N
VVIS
L
FF
MLG
C
-----
I
PP
M
L
WL
N
TAG
RR
PL
L
I
GS
F
AM
M
TLA
LAVLG
L
IP
D
M
G
IW
--------
LVVM
A
F
A
-
VY
AF
F
S
GG
PG
NL
QW
LYP
N
ELFPTDIR
AS
A
VG
V
IM
S
LSRIG
T
I
VST
WA
LP
I
------
F
I
N
N
YG
-
I
S
N
TML
M
GA
G
I
S
L
F
GL
L
IS
VA
FAPETR
G
MSL
AQT
SN
M
TIRGQRMG
fig|749550.3.peg.2558
Escherichia coli MS 200-1
MQPSRNFDDL
KF
S
SI
H
R
RI
LLWG
SG
GP
F
LDGYVL
VM
IGVAL
E
QLTPA
LK
L
DA
D
WI
G
LL
G
AGT
L
A
GLFVG
TS
LF
GYISD
KV
GRRK
M
F
L
ID
I
I
A
IGV
I
S
VATM
FV
SS
P
VE
L
L
VM
R
V
LIGI
V
IGADY
P
IA
T
S
MI
TEFS
S
T
R
Q
R
A
FSISFIA
--------
AM
W
Y
VG
ATC
A
D
L
VG
-
YWLYDVEGG
WRWML
G
SAAIP
C
LLI
LIG
R
F
EL
--------------------
PESPRWLLRKGR
V
K
E
C
E
EM
M
I
K
L
FG
EP
V
AFDE
EQ
PQQ
T
-
-
R
F
R
-----
--
--------------
D
LF
NR
R
HF
PFV
LF
VAAIWT
C
Q
--
VIP
M
F
A
IYT
F
G
P
Q
I
VGLL
GL
G
V
G
K
N
A
ALG
N
VVIS
L
FF
MLG
C
-----
I
PP
M
L
WL
N
TAG
RR
PL
L
I
GS
F
AM
M
TLA
LAVLG
L
IP
D
M
G
IW
--------
LVVM
A
F
A
-
VY
AF
F
S
GG
PG
NL
QW
LYP
N
ELFPTDIR
AS
A
VG
V
IM
S
LSRIG
T
I
VST
WA
LP
I
------
F
I
N
N
YG
-
I
S
N
TML
M
GA
G
I
S
L
F
GL
L
IS
VA
FAPETR
G
MSL
AQT
SN
M
TIRGQRMG
fig|749531.3.peg.1231
Escherichia coli MS 69-1
MQPSRNFDDL
KF
S
SI
H
R
RI
LLWG
SG
GP
F
LDGYVL
VM
IGVAL
E
QLTPA
LK
L
DA
D
WI
G
LL
G
AGT
L
A
GLFVG
TS
LF
GYISD
KV
GRRK
M
F
L
ID
I
I
A
IGV
I
S
VATM
FV
SS
P
VE
L
L
VM
R
V
LIGI
V
IGADY
P
IA
T
S
MI
TEFS
S
T
R
Q
R
A
FSISFIA
--------
AM
W
Y
VG
ATC
A
D
L
VG
-
YWLYDVEGG
WRWML
G
SAAIP
C
LLI
LIG
R
F
EL
--------------------
PESPRWLLRKGR
V
K
E
C
E
EM
M
I
K
L
FG
EP
V
AFDE
EQ
PQQ
T
-
-
R
F
R
-----
--
--------------
D
LF
NR
R
HF
PFV
LF
VAAIWT
C
Q
--
VIP
M
F
A
IYT
F
G
P
Q
I
VGLL
GL
G
V
G
K
N
A
ALG
N
VVIS
L
FF
MLG
C
-----
I
PP
M
L
WL
N
TAG
RR
PL
L
I
GS
F
AM
M
TLA
LAVLG
L
IP
D
M
G
IW
--------
LVVM
A
F
A
-
VY
AF
F
S
GG
PG
NL
QW
LYP
N
ELFPTDIR
AS
A
VG
V
IM
S
LSRIG
T
I
VST
WA
LP
I
------
F
I
N
N
YG
-
I
S
N
TML
M
GA
G
I
S
L
F
GL
L
IS
VA
FAPETR
G
MSL
AQT
SN
M
TIRGQRMG
fig|749532.3.peg.4222
Escherichia coli MS 78-1
MQPSRNFDDL
KF
S
SI
H
R
RI
LLWG
SG
GP
F
LDGYVL
VM
IGVAL
E
QLTPA
LK
L
DA
D
WI
G
LL
G
AGT
L
A
GLFVG
TS
LF
GYISD
KV
GRRK
M
F
L
ID
I
I
A
IGV
I
S
VATM
FV
SS
P
VE
L
L
VM
R
V
LIGI
V
IGADY
P
IA
T
S
MI
TEFS
S
T
R
Q
R
A
FSISFIA
--------
AM
W
Y
VG
ATC
A
D
L
VG
-
YWLYDVEGG
WRWML
G
SAAIP
C
LLI
LIG
R
F
EL
--------------------
PESPRWLLRKGR
V
K
E
C
E
EM
M
I
K
L
FG
EP
V
AFDE
EQ
PQQ
T
-
-
R
F
R
-----
--
--------------
D
LF
NR
R
HF
PFV
LF
VAAIWT
C
Q
--
VIP
M
F
A
IYT
F
G
P
Q
I
VGLL
GL
G
V
G
K
N
A
ALG
N
VVIS
L
FF
MLG
C
-----
I
PP
M
L
WL
N
TAG
RR
PL
L
I
GS
F
AM
M
TLA
LAVLG
L
IP
D
M
G
IW
--------
LVVM
A
F
A
-
VY
AF
F
S
GG
PG
NL
QW
LYP
N
ELFPTDIR
AS
A
VG
V
IM
S
LSRIG
T
I
VST
WA
LP
I
------
F
I
N
N
YG
-
I
S
N
TML
M
GA
G
I
S
L
F
GL
L
IS
VA
FAPETR
G
MSL
AQT
SN
M
TIRGQRMG
fig|749533.3.peg.3328
Escherichia coli MS 84-1
MQPSRNFDDL
KF
S
SI
H
R
RI
LLWG
SG
GP
F
LDGYVL
VM
IGVAL
E
QLTPA
LK
L
DA
D
WI
G
LL
G
AGT
L
A
GLFVG
TS
LF
GYISD
KV
GRRK
M
F
L
ID
I
I
A
IGV
I
S
VATM
FV
SS
P
VE
L
L
VM
R
V
LIGI
V
IGADY
P
IA
T
S
MI
TEFS
S
T
R
Q
R
A
FSISFIA
--------
AM
W
Y
VG
ATC
A
D
L
VG
-
YWLYDVEGG
WRWML
G
SAAIP
C
LLI
LIG
R
F
EL
--------------------
PESPRWLLRKGR
V
K
E
C
E
EM
M
I
K
L
FG
EP
V
AFDE
EQ
PQQ
T
-
-
R
F
R
-----
--
--------------
D
LF
NR
R
HF
PFV
LF
VAAIWT
C
Q
--
VIP
M
F
A
IYT
F
G
P
Q
I
VGLL
GL
G
V
G
K
N
A
ALG
N
VVIS
L
FF
MLG
C
-----
I
PP
M
L
WL
N
TAG
RR
PL
L
I
GS
F
AM
M
TLA
LAVLG
L
IP
D
M
G
IW
--------
LVVM
A
F
A
-
VY
AF
F
S
GG
PG
NL
QW
LYP
N
ELFPTDIR
AS
A
VG
V
IM
S
LSRIG
T
I
VST
WA
LP
I
------
F
I
N
N
YG
-
I
S
N
TML
M
GA
G
I
S
L
F
GL
L
IS
VA
FAPETR
G
MSL
AQT
SN
M
TIRGQRMG
fig|585395.4.peg.46
Escherichia coli O103:H2 str. 12009
MQPSRNFDDL
KF
S
SI
H
R
RI
LLWG
SG
GP
F
LDGYVL
VM
IGVAL
E
QLTPA
LK
L
DA
D
WI
G
LL
G
AGT
L
A
GLFVG
TS
LF
GYISD
KV
GRRK
M
F
L
ID
I
I
A
IGV
I
S
VATM
FV
SS
P
VE
L
L
VM
R
V
LIGI
V
IGADY
P
IA
T
S
MI
TEFS
S
T
R
Q
R
A
FSISFIA
--------
AM
W
Y
VG
ATC
A
D
L
VG
-
YWLYDVEGG
WRWML
G
SAAIP
C
LLI
LIG
R
F
EL
--------------------
PESPRWLLRKGR
V
K
E
C
E
EM
M
I
K
L
FG
EP
V
AFDE
EQ
PQQ
T
-
-
R
F
R
-----
--
--------------
D
LF
NR
R
HF
PFV
LF
VAAIWT
C
Q
--
VIP
M
F
A
IYT
F
G
P
Q
I
VGLL
GL
G
V
G
K
N
A
ALG
N
VVIS
L
FF
MLG
C
-----
I
PP
M
L
WL
N
TAG
RR
PL
L
I
GS
F
AM
M
TLA
LAVLG
L
IP
D
M
G
IW
--------
LVVM
A
F
A
-
VY
AF
F
S
GG
PG
NL
QW
LYP
N
ELFPTDIR
AS
A
VG
V
IM
S
LSRIG
T
I
VST
WA
LP
I
------
F
I
N
N
YG
-
I
S
N
TML
M
GA
G
I
S
L
F
GL
L
IS
VA
FAPETR
G
MSL
AQT
SN
M
TIRGQRMG
fig|585396.4.peg.46
Escherichia coli O111:H- str. 11128
MQPSRNFDDL
KF
S
SI
H
R
RI
LLWG
SG
GP
F
LDGYVL
VM
IGVAL
E
QLTPA
LK
L
DA
D
WI
G
LL
G
AGT
L
A
GLFVG
TS
LF
GYISD
KV
GRRK
M
F
L
ID
I
I
A
IGV
I
S
VATM
FV
SS
P
VE
L
L
VM
R
V
LIGI
V
IGADY
P
IA
T
S
MI
TEFS
S
T
R
Q
R
A
FSISFIA
--------
AM
W
Y
VG
ATC
A
D
L
VG
-
YWLYDVEGG
WRWML
G
SAAIP
C
LLI
LIG
R
F
EL
--------------------
PESPRWLLRKGR
V
K
E
C
E
EM
M
I
K
L
FG
EP
V
AFDE
EQ
PQQ
T
-
-
R
F
R
-----
--
--------------
D
LF
NR
R
HF
PFV
LF
VAAIWT
C
Q
--
VIP
M
F
A
IYT
F
G
P
Q
I
VGLL
GL
G
V
G
K
N
A
ALG
N
VVIS
L
FF
MLG
C
-----
I
PP
M
L
WL
N
TAG
RR
PL
L
I
GS
F
AM
M
TLA
LAVLG
L
IP
D
M
G
IW
--------
LVVM
A
F
A
-
VY
AF
F
S
GG
PG
NL
QW
LYP
N
ELFPTDIR
AS
A
VG
V
IM
S
LSRIG
T
I
VST
WA
LP
I
------
F
I
N
N
YG
-
I
S
N
TML
M
GA
G
I
S
L
F
GL
L
IS
VA
FAPETR
G
MSL
AQT
SN
M
TIRGQRMG
fig|573235.3.peg.47
Escherichia coli O26:H11 str. 11368
MQPSRNFDDL
KF
S
SI
H
R
RI
LLWG
SG
GP
F
LDGYVL
VM
IGVAL
E
QLTPA
LK
L
DA
D
WI
G
LL
G
AGT
L
A
GLFVG
TS
LF
GYISD
KV
GRRK
M
F
L
ID
I
I
A
IGV
I
S
VATM
FV
SS
P
VE
L
L
VM
R
V
LIGI
V
IGADY
P
IA
T
S
MI
TEFS
S
T
R
Q
R
A
FSISFIA
--------
AM
W
Y
VG
ATC
A
D
L
VG
-
YWLYDVEGG
WRWML
G
SAAIP
C
LLI
LIG
R
F
EL
--------------------
PESPRWLLRKGR
V
K
E
C
E
EM
M
I
K
L
FG
EP
V
AFDE
EQ
PQQ
T
-
-
R
F
R
-----
--
--------------
D
LF
NR
R
HF
PFV
LF
VAAIWT
C
Q
--
VIP
M
F
A
IYT
F
G
P
Q
I
VGLL
GL
G
V
G
K
N
A
ALG
N
VVIS
L
FF
MLG
C
-----
I
PP
M
L
WL
N
TAG
RR
PL
L
I
GS
F
AM
M
TLA
LAVLG
L
IP
D
M
G
IW
--------
LVVM
A
F
A
-
VY
AF
F
S
GG
PG
NL
QW
LYP
N
ELFPTDIR
AS
A
VG
V
IM
S
LSRIG
T
I
VST
WA
LP
I
------
F
I
N
N
YG
-
I
S
N
TML
M
GA
G
I
S
L
F
GL
L
IS
VA
FAPETR
G
MSL
AQT
SN
M
TIRGQRMG
fig|409438.11.peg.163
Escherichia coli SE11
MQPSRNFDDL
KF
S
SI
H
R
RI
LLWG
SG
GP
F
LDGYVL
VM
IGVAL
E
QLTPA
LK
L
DA
D
WI
G
LL
G
AGT
L
A
GLFVG
TS
LF
GYISD
KV
GRRK
M
F
L
ID
I
I
A
IGV
I
S
VATM
FV
SS
P
VE
L
L
VM
R
V
LIGI
V
IGADY
P
IA
T
S
MI
TEFS
S
T
R
Q
R
A
FSISFIA
--------
AM
W
Y
VG
ATC
A
D
L
VG
-
YWLYDVEGG
WRWML
G
SAAIP
C
LLI
LIG
R
F
EL
--------------------
PESPRWLLRKGR
V
K
E
C
E
EM
M
I
K
L
FG
EP
V
AFDE
EQ
PQQ
T
-
-
R
F
R
-----
--
--------------
D
LF
NR
R
HF
PFV
LF
VAAIWT
C
Q
--
VIP
M
F
A
IYT
F
G
P
Q
I
VGLL
GL
G
V
G
K
N
A
ALG
N
VVIS
L
FF
MLG
C
-----
I
PP
M
L
WL
N
TAG
RR
PL
L
I
GS
F
AM
M
TLA
LAVLG
L
IP
D
M
G
IW
--------
LVVM
A
F
A
-
VY
AF
F
S
GG
PG
NL
QW
LYP
N
ELFPTDIR
AS
A
VG
V
IM
S
LSRIG
T
I
VST
WA
LP
I
------
F
I
N
N
YG
-
I
S
N
TML
M
GA
G
I
S
L
F
GL
L
IS
VA
FAPETR
G
MSL
AQT
SN
M
TIRGQRMG
fig|656437.3.peg.101
Escherichia coli TA143
MQPSRNFDDL
KF
S
SI
H
R
RI
LLWG
SG
GP
F
LDGYVL
VM
IGVAL
E
QLTPA
LK
L
DA
D
WI
G
LL
G
AGT
L
A
GLFVG
TS
LF
GYISD
KV
GRRK
M
F
L
ID
I
I
A
IGV
I
S
VATM
FV
SS
P
VE
L
L
VM
R
V
LIGI
V
IGADY
P
IA
T
S
MI
TEFS
S
T
R
Q
R
A
FSISFIA
--------
AM
W
Y
VG
ATC
A
D
L
VG
-
YWLYDVEGG
WRWML
G
SAAIP
C
LLI
LIG
R
F
EL
--------------------
PESPRWLLRKGR
V
K
E
C
E
EM
M
I
K
L
FG
EP
V
AFDE
EQ
PQQ
T
-
-
R
F
R
-----
--
--------------
D
LF
NR
R
HF
PFV
LF
VAAIWT
C
Q
--
VIP
M
F
A
IYT
F
G
P
Q
I
VGLL
GL
G
V
G
K
N
A
ALG
N
VVIS
L
FF
MLG
C
-----
I
PP
M
L
WL
N
TAG
RR
PL
L
I
GS
F
AM
M
TLA
LAVLG
L
IP
D
M
G
IW
--------
LVVM
A
F
A
-
VY
AF
F
S
GG
PG
NL
QW
LYP
N
ELFPTDIR
AS
A
VG
V
IM
S
LSRIG
T
I
VST
WA
LP
I
------
F
I
N
N
YG
-
I
S
N
TML
M
GA
G
I
S
L
F
GL
L
IS
VA
FAPETR
G
MSL
AQT
SN
M
TIRGQRMG
fig|656443.3.peg.172
Escherichia coli TA271
MQPSRNFDDL
KF
S
SI
H
R
RI
LLWG
SG
GP
F
LDGYVL
VM
IGVAL
E
QLTPA
LK
L
DA
D
WI
G
LL
G
AGT
L
A
GLFVG
TS
LF
GYISD
KV
GRRK
M
F
L
ID
I
I
A
IGV
I
S
VATM
FV
SS
P
VE
L
L
VM
R
V
LIGI
V
IGADY
P
IA
T
S
MI
TEFS
S
T
R
Q
R
A
FSISFIA
--------
AM
W
Y
VG
ATC
A
D
L
VG
-
YWLYDVEGG
WRWML
G
SAAIP
C
LLI
LIG
R
F
EL
--------------------
PESPRWLLRKGR
V
K
E
C
E
EM
M
I
K
L
FG
EP
V
AFDE
EQ
PQQ
T
-
-
R
F
R
-----
--
--------------
D
LF
NR
R
HF
PFV
LF
VAAIWT
C
Q
--
VIP
M
F
A
IYT
F
G
P
Q
I
VGLL
GL
G
V
G
K
N
A
ALG
N
VVIS
L
FF
MLG
C
-----
I
PP
M
L
WL
N
TAG
RR
PL
L
I
GS
F
AM
M
TLA
LAVLG
L
IP
D
M
G
IW
--------
LVVM
A
F
A
-
VY
AF
F
S
GG
PG
NL
QW
LYP
N
ELFPTDIR
AS
A
VG
V
IM
S
LSRIG
T
I
VST
WA
LP
I
------
F
I
N
N
YG
-
I
S
N
TML
M
GA
G
I
S
L
F
GL
L
IS
VA
FAPETR
G
MSL
AQT
SN
M
TIRGQRMG
fig|656444.3.peg.375
Escherichia coli TA280
MQPSRNFDDL
KF
S
SI
H
R
RI
LLWG
SG
GP
F
LDGYVL
VM
IGVAL
E
QLTPA
LK
L
DA
D
WI
G
LL
G
AGT
L
A
GLFVG
TS
LF
GYISD
KV
GRRK
M
F
L
ID
I
I
A
IGV
I
S
VATM
FV
SS
P
VE
L
L
VM
R
V
LIGI
V
IGADY
P
IA
T
S
MI
TEFS
S
T
R
Q
R
A
FSISFIA
--------
AM
W
Y
VG
ATC
A
D
L
VG
-
YWLYDVEGG
WRWML
G
SAAIP
C
LLI
LIG
R
F
EL
--------------------
PESPRWLLRKGR
V
K
E
C
E
EM
M
I
K
L
FG
EP
V
AFDE
EQ
PQQ
T
-
-
R
F
R
-----
--
--------------
D
LF
NR
R
HF
PFV
LF
VAAIWT
C
Q
--
VIP
M
F
A
IYT
F
G
P
Q
I
VGLL
GL
G
V
G
K
N
A
ALG
N
VVIS
L
FF
MLG
C
-----
I
PP
M
L
WL
N
TAG
RR
PL
L
I
GS
F
AM
M
TLA
LAVLG
L
IP
D
M
G
IW
--------
LVVM
A
F
A
-
VY
AF
F
S
GG
PG
NL
QW
LYP
N
ELFPTDIR
AS
A
VG
V
IM
S
LSRIG
T
I
VST
WA
LP
I
------
F
I
N
N
YG
-
I
S
N
TML
M
GA
G
I
S
L
F
GL
L
IS
VA
FAPETR
G
MSL
AQT
SN
M
TIRGQRMG
fig|585056.7.peg.234
Escherichia coli UMN026
MQPSRNFDDL
KF
S
SI
H
R
RI
LLWG
SG
GP
F
LDGYVL
VM
IGVAL
E
QLTPA
LK
L
DA
D
WI
G
LL
G
AGT
L
A
GLFVG
TS
LF
GYISD
KV
GRRK
M
F
L
ID
I
I
A
IGV
I
S
VATM
FV
SS
P
VE
L
L
VM
R
V
LIGI
V
IGADY
P
IA
T
S
MI
TEFS
S
T
R
Q
R
A
FSISFIA
--------
AM
W
Y
VG
ATC
A
D
L
VG
-
YWLYDVEGG
WRWML
G
SAAIP
C
LLI
LIG
R
F
EL
--------------------
PESPRWLLRKGR
V
K
E
C
E
EM
M
I
K
L
FG
EP
V
AFDE
EQ
PQQ
T
-
-
R
F
R
-----
--
--------------
D
LF
NR
R
HF
PFV
LF
VAAIWT
C
Q
--
VIP
M
F
A
IYT
F
G
P
Q
I
VGLL
GL
G
V
G
K
N
A
ALG
N
VVIS
L
FF
MLG
C
-----
I
PP
M
L
WL
N
TAG
RR
PL
L
I
GS
F
AM
M
TLA
LAVLG
L
IP
D
M
G
IW
--------
LVVM
A
F
A
-
VY
AF
F
S
GG
PG
NL
QW
LYP
N
ELFPTDIR
AS
A
VG
V
IM
S
LSRIG
T
I
VST
WA
LP
I
------
F
I
N
N
YG
-
I
S
N
TML
M
GA
G
I
S
L
F
GL
L
IS
VA
FAPETR
G
MSL
AQT
SN
M
TIRGQRMG
fig|566546.3.peg.1688
Escherichia coli W
MQPSRNFDDL
KF
S
SI
H
R
RI
LLWG
SG
GP
F
LDGYVL
VM
IGVAL
E
QLTPA
LK
L
DA
D
WI
G
LL
G
AGT
L
A
GLFVG
TS
LF
GYISD
KV
GRRK
M
F
L
ID
I
I
A
IGV
I
S
VATM
FV
SS
P
VE
L
L
VM
R
V
LIGI
V
IGADY
P
IA
T
S
MI
TEFS
S
T
R
Q
R
A
FSISFIA
--------
AM
W
Y
VG
ATC
A
D
L
VG
-
YWLYDVEGG
WRWML
G
SAAIP
C
LLI
LIG
R
F
EL
--------------------
PESPRWLLRKGR
V
K
E
C
E
EM
M
I
K
L
FG
EP
V
AFDE
EQ
PQQ
T
-
-
R
F
R
-----
--
--------------
D
LF
NR
R
HF
PFV
LF
VAAIWT
C
Q
--
VIP
M
F
A
IYT
F
G
P
Q
I
VGLL
GL
G
V
G
K
N
A
ALG
N
VVIS
L
FF
MLG
C
-----
I
PP
M
L
WL
N
TAG
RR
PL
L
I
GS
F
AM
M
TLA
LAVLG
L
IP
D
M
G
IW
--------
LVVM
A
F
A
-
VY
AF
F
S
GG
PG
NL
QW
LYP
N
ELFPTDIR
AS
A
VG
V
IM
S
LSRIG
T
I
VST
WA
LP
I
------
F
I
N
N
YG
-
I
S
N
TML
M
GA
G
I
S
L
F
GL
L
IS
VA
FAPETR
G
MSL
AQT
SN
M
TIRGQRMG
fig|566546.4.peg.44
Escherichia coli W
MQPSRNFDDL
KF
S
SI
H
R
RI
LLWG
SG
GP
F
LDGYVL
VM
IGVAL
E
QLTPA
LK
L
DA
D
WI
G
LL
G
AGT
L
A
GLFVG
TS
LF
GYISD
KV
GRRK
M
F
L
ID
I
I
A
IGV
I
S
VATM
FV
SS
P
VE
L
L
VM
R
V
LIGI
V
IGADY
P
IA
T
S
MI
TEFS
S
T
R
Q
R
A
FSISFIA
--------
AM
W
Y
VG
ATC
A
D
L
VG
-
YWLYDVEGG
WRWML
G
SAAIP
C
LLI
LIG
R
F
EL
--------------------
PESPRWLLRKGR
V
K
E
C
E
EM
M
I
K
L
FG
EP
V
AFDE
EQ
PQQ
T
-
-
R
F
R
-----
--
--------------
D
LF
NR
R
HF
PFV
LF
VAAIWT
C
Q
--
VIP
M
F
A
IYT
F
G
P
Q
I
VGLL
GL
G
V
G
K
N
A
ALG
N
VVIS
L
FF
MLG
C
-----
I
PP
M
L
WL
N
TAG
RR
PL
L
I
GS
F
AM
M
TLA
LAVLG
L
IP
D
M
G
IW
--------
LVVM
A
F
A
-
VY
AF
F
S
GG
PG
NL
QW
LYP
N
ELFPTDIR
AS
A
VG
V
IM
S
LSRIG
T
I
VST
WA
LP
I
------
F
I
N
N
YG
-
I
S
N
TML
M
GA
G
I
S
L
F
GL
L
IS
VA
FAPETR
G
MSL
AQT
SN
M
TIRGQRMG
fig|316407.3.peg.45
Escherichia coli W3110
MQPSRNFDDL
KF
S
SI
H
R
RI
LLWG
SG
GP
F
LDGYVL
VM
IGVAL
E
QLTPA
LK
L
DA
D
WI
G
LL
G
AGT
L
A
GLFVG
TS
LF
GYISD
KV
GRRK
M
F
L
ID
I
I
A
IGV
I
S
VATM
FV
SS
P
VE
L
L
VM
R
V
LIGI
V
IGADY
P
IA
T
S
MI
TEFS
S
T
R
Q
R
A
FSISFIA
--------
AM
W
Y
VG
ATC
A
D
L
VG
-
YWLYDVEGG
WRWML
G
SAAIP
C
LLI
LIG
R
F
EL
--------------------
PESPRWLLRKGR
V
K
E
C
E
EM
M
I
K
L
FG
EP
V
AFDE
EQ
PQQ
T
-
-
R
F
R
-----
--
--------------
D
LF
NR
R
HF
PFV
LF
VAAIWT
C
Q
--
VIP
M
F
A
IYT
F
G
P
Q
I
VGLL
GL
G
V
G
K
N
A
ALG
N
VVIS
L
FF
MLG
C
-----
I
PP
M
L
WL
N
TAG
RR
PL
L
I
GS
F
AM
M
TLA
LAVLG
L
IP
D
M
G
IW
--------
LVVM
A
F
A
-
VY
AF
F
S
GG
PG
NL
QW
LYP
N
ELFPTDIR
AS
A
VG
V
IM
S
LSRIG
T
I
VST
WA
LP
I
------
F
I
N
N
YG
-
I
S
N
TML
M
GA
G
I
S
L
F
GL
L
IS
VA
FAPETR
G
MSL
AQT
SN
M
TIRGQRMG
fig|316385.5.peg.48
Escherichia coli str. K-12 substr. DH10B
MQPSRNFDDL
KF
S
SI
H
R
RI
LLWG
SG
GP
F
LDGYVL
VM
IGVAL
E
QLTPA
LK
L
DA
D
WI
G
LL
G
AGT
L
A
GLFVG
TS
LF
GYISD
KV
GRRK
M
F
L
ID
I
I
A
IGV
I
S
VATM
FV
SS
P
VE
L
L
VM
R
V
LIGI
V
IGADY
P
IA
T
S
MI
TEFS
S
T
R
Q
R
A
FSISFIA
--------
AM
W
Y
VG
ATC
A
D
L
VG
-
YWLYDVEGG
WRWML
G
SAAIP
C
LLI
LIG
R
F
EL
--------------------
PESPRWLLRKGR
V
K
E
C
E
EM
M
I
K
L
FG
EP
V
AFDE
EQ
PQQ
T
-
-
R
F
R
-----
--
--------------
D
LF
NR
R
HF
PFV
LF
VAAIWT
C
Q
--
VIP
M
F
A
IYT
F
G
P
Q
I
VGLL
GL
G
V
G
K
N
A
ALG
N
VVIS
L
FF
MLG
C
-----
I
PP
M
L
WL
N
TAG
RR
PL
L
I
GS
F
AM
M
TLA
LAVLG
L
IP
D
M
G
IW
--------
LVVM
A
F
A
-
VY
AF
F
S
GG
PG
NL
QW
LYP
N
ELFPTDIR
AS
A
VG
V
IM
S
LSRIG
T
I
VST
WA
LP
I
------
F
I
N
N
YG
-
I
S
N
TML
M
GA
G
I
S
L
F
GL
L
IS
VA
FAPETR
G
MSL
AQT
SN
M
TIRGQRMG
fig|316385.7.peg.47
Escherichia coli str. K-12 substr. DH10B
MQPSRNFDDL
KF
S
SI
H
R
RI
LLWG
SG
GP
F
LDGYVL
VM
IGVAL
E
QLTPA
LK
L
DA
D
WI
G
LL
G
AGT
L
A
GLFVG
TS
LF
GYISD
KV
GRRK
M
F
L
ID
I
I
A
IGV
I
S
VATM
FV
SS
P
VE
L
L
VM
R
V
LIGI
V
IGADY
P
IA
T
S
MI
TEFS
S
T
R
Q
R
A
FSISFIA
--------
AM
W
Y
VG
ATC
A
D
L
VG
-
YWLYDVEGG
WRWML
G
SAAIP
C
LLI
LIG
R
F
EL
--------------------
PESPRWLLRKGR
V
K
E
C
E
EM
M
I
K
L
FG
EP
V
AFDE
EQ
PQQ
T
-
-
R
F
R
-----
--
--------------
D
LF
NR
R
HF
PFV
LF
VAAIWT
C
Q
--
VIP
M
F
A
IYT
F
G
P
Q
I
VGLL
GL
G
V
G
K
N
A
ALG
N
VVIS
L
FF
MLG
C
-----
I
PP
M
L
WL
N
TAG
RR
PL
L
I
GS
F
AM
M
TLA
LAVLG
L
IP
D
M
G
IW
--------
LVVM
A
F
A
-
VY
AF
F
S
GG
PG
NL
QW
LYP
N
ELFPTDIR
AS
A
VG
V
IM
S
LSRIG
T
I
VST
WA
LP
I
------
F
I
N
N
YG
-
I
S
N
TML
M
GA
G
I
S
L
F
GL
L
IS
VA
FAPETR
G
MSL
AQT
SN
M
TIRGQRMG
fig|511145.12.peg.46
Escherichia coli str. K-12 substr. MG1655
MQPSRNFDDL
KF
S
SI
H
R
RI
LLWG
SG
GP
F
LDGYVL
VM
IGVAL
E
QLTPA
LK
L
DA
D
WI
G
LL
G
AGT
L
A
GLFVG
TS
LF
GYISD
KV
GRRK
M
F
L
ID
I
I
A
IGV
I
S
VATM
FV
SS
P
VE
L
L
VM
R
V
LIGI
V
IGADY
P
IA
T
S
MI
TEFS
S
T
R
Q
R
A
FSISFIA
--------
AM
W
Y
VG
ATC
A
D
L
VG
-
YWLYDVEGG
WRWML
G
SAAIP
C
LLI
LIG
R
F
EL
--------------------
PESPRWLLRKGR
V
K
E
C
E
EM
M
I
K
L
FG
EP
V
AFDE
EQ
PQQ
T
-
-
R
F
R
-----
--
--------------
D
LF
NR
R
HF
PFV
LF
VAAIWT
C
Q
--
VIP
M
F
A
IYT
F
G
P
Q
I
VGLL
GL
G
V
G
K
N
A
ALG
N
VVIS
L
FF
MLG
C
-----
I
PP
M
L
WL
N
TAG
RR
PL
L
I
GS
F
AM
M
TLA
LAVLG
L
IP
D
M
G
IW
--------
LVVM
A
F
A
-
VY
AF
F
S
GG
PG
NL
QW
LYP
N
ELFPTDIR
AS
A
VG
V
IM
S
LSRIG
T
I
VST
WA
LP
I
------
F
I
N
N
YG
-
I
S
N
TML
M
GA
G
I
S
L
F
GL
L
IS
VA
FAPETR
G
MSL
AQT
SN
M
TIRGQRMG
fig|511145.6.peg.47
Escherichia coli str. K-12 substr. MG1655
MQPSRNFDDL
KF
S
SI
H
R
RI
LLWG
SG
GP
F
LDGYVL
VM
IGVAL
E
QLTPA
LK
L
DA
D
WI
G
LL
G
AGT
L
A
GLFVG
TS
LF
GYISD
KV
GRRK
M
F
L
ID
I
I
A
IGV
I
S
VATM
FV
SS
P
VE
L
L
VM
R
V
LIGI
V
IGADY
P
IA
T
S
MI
TEFS
S
T
R
Q
R
A
FSISFIA
--------
AM
W
Y
VG
ATC
A
D
L
VG
-
YWLYDVEGG
WRWML
G
SAAIP
C
LLI
LIG
R
F
EL
--------------------
PESPRWLLRKGR
V
K
E
C
E
EM
M
I
K
L
FG
EP
V
AFDE
EQ
PQQ
T
-
-
R
F
R
-----
--
--------------
D
LF
NR
R
HF
PFV
LF
VAAIWT
C
Q
--
VIP
M
F
A
IYT
F
G
P
Q
I
VGLL
GL
G
V
G
K
N
A
ALG
N
VVIS
L
FF
MLG
C
-----
I
PP
M
L
WL
N
TAG
RR
PL
L
I
GS
F
AM
M
TLA
LAVLG
L
IP
D
M
G
IW
--------
LVVM
A
F
A
-
VY
AF
F
S
GG
PG
NL
QW
LYP
N
ELFPTDIR
AS
A
VG
V
IM
S
LSRIG
T
I
VST
WA
LP
I
------
F
I
N
N
YG
-
I
S
N
TML
M
GA
G
I
S
L
F
GL
L
IS
VA
FAPETR
G
MSL
AQT
SN
M
TIRGQRMG
fig|562.371.peg.3980
Escherichia coli 1044A
MQPSRNFDDL
KF
S
SI
H
R
RI
LLWG
SG
GP
F
LDGY
I
L
VM
IGVAL
E
QLTPA
LK
L
DA
D
WI
G
LL
G
AGT
L
A
GLFVG
TS
LF
GYISD
KV
GRRK
M
F
L
ID
I
I
A
IGV
I
S
VATM
FV
SS
P
VE
L
L
VM
R
V
LIGI
V
IGADY
P
IA
T
S
MI
TEFS
S
T
R
Q
R
A
FSISFIA
--------
AM
W
Y
VG
ATC
A
D
L
VG
-
YWLYDVEGG
WRWML
G
SAAIP
C
LLI
LIG
R
F
EL
--------------------
PESPRWLLRKGR
V
K
E
C
E
EM
M
I
K
L
FG
EP
V
AFDE
EQ
PQQ
T
-
-
R
F
R
-----
--
--------------
D
LF
NR
R
HF
PFV
LF
VAAIWT
C
Q
--
VIP
M
F
A
IYT
F
G
P
Q
I
VGLL
GL
G
V
G
K
N
A
ALG
N
VVIS
L
FF
MLG
C
-----
I
PP
M
L
WL
N
TAG
RR
PL
L
I
GS
F
AM
M
TLA
LAVLG
L
IP
D
M
G
IW
--------
LVVM
A
F
A
-
VY
AF
F
S
GG
PG
NL
QW
LYP
N
ELFPTDIR
AS
A
VG
V
IM
S
LSRIG
T
I
VST
WA
LP
I
------
F
I
N
N
YG
-
I
S
N
TML
M
GA
G
I
S
L
F
GL
L
IS
VA
FAPETR
G
MSL
AQT
SN
M
TIRGQRMG
fig|562.373.peg.2225
Escherichia coli 1125A
MQPSRNFDDL
KF
S
SI
H
R
RI
LLWG
SG
GP
F
LDGY
I
L
VM
IGVAL
E
QLTPA
LK
L
DA
D
WI
G
LL
G
AGT
L
A
GLFVG
TS
LF
GYISD
KV
GRRK
M
F
L
ID
I
I
A
IGV
I
S
VATM
FV
SS
P
VE
L
L
VM
R
V
LIGI
V
IGADY
P
IA
T
S
MI
TEFS
S
T
R
Q
R
A
FSISFIA
--------
AM
W
Y
VG
ATC
A
D
L
VG
-
YWLYDVEGG
WRWML
G
SAAIP
C
LLI
LIG
R
F
EL
--------------------
PESPRWLLRKGR
V
K
E
C
E
EM
M
I
K
L
FG
EP
V
AFDE
EQ
PQQ
T
-
-
R
F
R
-----
--
--------------
D
LF
NR
R
HF
PFV
LF
VAAIWT
C
Q
--
VIP
M
F
A
IYT
F
G
P
Q
I
VGLL
GL
G
V
G
K
N
A
ALG
N
VVIS
L
FF
MLG
C
-----
I
PP
M
L
WL
N
TAG
RR
PL
L
I
GS
F
AM
M
TLA
LAVLG
L
IP
D
M
G
IW
--------
LVVM
A
F
A
-
VY
AF
F
S
GG
PG
NL
QW
LYP
N
ELFPTDIR
AS
A
VG
V
IM
S
LSRIG
T
I
VST
WA
LP
I
------
F
I
N
N
YG
-
I
S
N
TML
M
GA
G
I
S
L
F
GL
L
IS
VA
FAPETR
G
MSL
AQT
SN
M
TIRGQRMG
fig|562.372.peg.3076
Escherichia coli 1212A
MQPSRNFDDL
KF
S
SI
H
R
RI
LLWG
SG
GP
F
LDGY
I
L
VM
IGVAL
E
QLTPA
LK
L
DA
D
WI
G
LL
G
AGT
L
A
GLFVG
TS
LF
GYISD
KV
GRRK
M
F
L
ID
I
I
A
IGV
I
S
VATM
FV
SS
P
VE
L
L
VM
R
V
LIGI
V
IGADY
P
IA
T
S
MI
TEFS
S
T
R
Q
R
A
FSISFIA
--------
AM
W
Y
VG
ATC
A
D
L
VG
-
YWLYDVEGG
WRWML
G
SAAIP
C
LLI
LIG
R
F
EL
--------------------
PESPRWLLRKGR
V
K
E
C
E
EM
M
I
K
L
FG
EP
V
AFDE
EQ
PQQ
T
-
-
R
F
R
-----
--
--------------
D
LF
NR
R
HF
PFV
LF
VAAIWT
C
Q
--
VIP
M
F
A
IYT
F
G
P
Q
I
VGLL
GL
G
V
G
K
N
A
ALG
N
VVIS
L
FF
MLG
C
-----
I
PP
M
L
WL
N
TAG
RR
PL
L
I
GS
F
AM
M
TLA
LAVLG
L
IP
D
M
G
IW
--------
LVVM
A
F
A
-
VY
AF
F
S
GG
PG
NL
QW
LYP
N
ELFPTDIR
AS
A
VG
V
IM
S
LSRIG
T
I
VST
WA
LP
I
------
F
I
N
N
YG
-
I
S
N
TML
M
GA
G
I
S
L
F
GL
L
IS
VA
FAPETR
G
MSL
AQT
SN
M
TIRGQRMG
fig|562.374.peg.2267
Escherichia coli 536A
MQPSRNFDDL
KF
S
SI
H
R
RI
LLWG
SG
GP
F
LDGY
I
L
VM
IGVAL
E
QLTPA
LK
L
DA
D
WI
G
LL
G
AGT
L
A
GLFVG
TS
LF
GYISD
KV
GRRK
M
F
L
ID
I
I
A
IGV
I
S
VATM
FV
SS
P
VE
L
L
VM
R
V
LIGI
V
IGADY
P
IA
T
S
MI
TEFS
S
T
R
Q
R
A
FSISFIA
--------
AM
W
Y
VG
ATC
A
D
L
VG
-
YWLYDVEGG
WRWML
G
SAAIP
C
LLI
LIG
R
F
EL
--------------------
PESPRWLLRKGR
V
K
E
C
E
EM
M
I
K
L
FG
EP
V
AFDE
EQ
PQQ
T
-
-
R
F
R
-----
--
--------------
D
LF
NR
R
HF
PFV
LF
VAAIWT
C
Q
--
VIP
M
F
A
IYT
F
G
P
Q
I
VGLL
GL
G
V
G
K
N
A
ALG
N
VVIS
L
FF
MLG
C
-----
I
PP
M
L
WL
N
TAG
RR
PL
L
I
GS
F
AM
M
TLA
LAVLG
L
IP
D
M
G
IW
--------
LVVM
A
F
A
-
VY
AF
F
S
GG
PG
NL
QW
LYP
N
ELFPTDIR
AS
A
VG
V
IM
S
LSRIG
T
I
VST
WA
LP
I
------
F
I
N
N
YG
-
I
S
N
TML
M
GA
G
I
S
L
F
GL
L
IS
VA
FAPETR
G
MSL
AQT
SN
M
TIRGQRMG
fig|83334.1.peg.136
Escherichia coli O157:H7
MQPSRNFDDL
KF
S
SI
H
R
RI
LLWG
SG
GP
F
LDGY
I
L
VM
IGVAL
E
QLTPA
LK
L
DA
D
WI
G
LL
G
AGT
L
A
GLFVG
TS
LF
GYISD
KV
GRRK
M
F
L
ID
I
I
A
IGV
I
S
VATM
FV
SS
P
VE
L
L
VM
R
V
LIGI
V
IGADY
P
IA
T
S
MI
TEFS
S
T
R
Q
R
A
FSISFIA
--------
AM
W
Y
VG
ATC
A
D
L
VG
-
YWLYDVEGG
WRWML
G
SAAIP
C
LLI
LIG
R
F
EL
--------------------
PESPRWLLRKGR
V
K
E
C
E
EM
M
I
K
L
FG
EP
V
AFDE
EQ
PQQ
T
-
-
R
F
R
-----
--
--------------
D
LF
NR
R
HF
PFV
LF
VAAIWT
C
Q
--
VIP
M
F
A
IYT
F
G
P
Q
I
VGLL
GL
G
V
G
K
N
A
ALG
N
VVIS
L
FF
MLG
C
-----
I
PP
M
L
WL
N
TAG
RR
PL
L
I
GS
F
AM
M
TLA
LAVLG
L
IP
D
M
G
IW
--------
LVVM
A
F
A
-
VY
AF
F
S
GG
PG
NL
QW
LYP
N
ELFPTDIR
AS
A
VG
V
IM
S
LSRIG
T
I
VST
WA
LP
I
------
F
I
N
N
YG
-
I
S
N
TML
M
GA
G
I
S
L
F
GL
L
IS
VA
FAPETR
G
MSL
AQT
SN
M
TIRGQRMG
fig|155864.1.peg.48
Escherichia coli O157:H7 EDL933
MQPSRNFDDL
KF
S
SI
H
R
RI
LLWG
SG
GP
F
LDGY
I
L
VM
IGVAL
E
QLTPA
LK
L
DA
D
WI
G
LL
G
AGT
L
A
GLFVG
TS
LF
GYISD
KV
GRRK
M
F
L
ID
I
I
A
IGV
I
S
VATM
FV
SS
P
VE
L
L
VM
R
V
LIGI
V
IGADY
P
IA
T
S
MI
TEFS
S
T
R
Q
R
A
FSISFIA
--------
AM
W
Y
VG
ATC
A
D
L
VG
-
YWLYDVEGG
WRWML
G
SAAIP
C
LLI
LIG
R
F
EL
--------------------
PESPRWLLRKGR
V
K
E
C
E
EM
M
I
K
L
FG
EP
V
AFDE
EQ
PQQ
T
-
-
R
F
R
-----
--
--------------
D
LF
NR
R
HF
PFV
LF
VAAIWT
C
Q
--
VIP
M
F
A
IYT
F
G
P
Q
I
VGLL
GL
G
V
G
K
N
A
ALG
N
VVIS
L
FF
MLG
C
-----
I
PP
M
L
WL
N
TAG
RR
PL
L
I
GS
F
AM
M
TLA
LAVLG
L
IP
D
M
G
IW
--------
LVVM
A
F
A
-
VY
AF
F
S
GG
PG
NL
QW
LYP
N
ELFPTDIR
AS
A
VG
V
IM
S
LSRIG
T
I
VST
WA
LP
I
------
F
I
N
N
YG
-
I
S
N
TML
M
GA
G
I
S
L
F
GL
L
IS
VA
FAPETR
G
MSL
AQT
SN
M
TIRGQRMG
fig|155864.8.peg.48
Escherichia coli O157:H7 EDL933
MQPSRNFDDL
KF
S
SI
H
R
RI
LLWG
SG
GP
F
LDGY
I
L
VM
IGVAL
E
QLTPA
LK
L
DA
D
WI
G
LL
G
AGT
L
A
GLFVG
TS
LF
GYISD
KV
GRRK
M
F
L
ID
I
I
A
IGV
I
S
VATM
FV
SS
P
VE
L
L
VM
R
V
LIGI
V
IGADY
P
IA
T
S
MI
TEFS
S
T
R
Q
R
A
FSISFIA
--------
AM
W
Y
VG
ATC
A
D
L
VG
-
YWLYDVEGG
WRWML
G
SAAIP
C
LLI
LIG
R
F
EL
--------------------
PESPRWLLRKGR
V
K
E
C
E
EM
M
I
K
L
FG
EP
V
AFDE
EQ
PQQ
T
-
-
R
F
R
-----
--
--------------
D
LF
NR
R
HF
PFV
LF
VAAIWT
C
Q
--
VIP
M
F
A
IYT
F
G
P
Q
I
VGLL
GL
G
V
G
K
N
A
ALG
N
VVIS
L
FF
MLG
C
-----
I
PP
M
L
WL
N
TAG
RR
PL
L
I
GS
F
AM
M
TLA
LAVLG
L
IP
D
M
G
IW
--------
LVVM
A
F
A
-
VY
AF
F
S
GG
PG
NL
QW
LYP
N
ELFPTDIR
AS
A
VG
V
IM
S
LSRIG
T
I
VST
WA
LP
I
------
F
I
N
N
YG
-
I
S
N
TML
M
GA
G
I
S
L
F
GL
L
IS
VA
FAPETR
G
MSL
AQT
SN
M
TIRGQRMG
fig|444454.5.peg.4511
Escherichia coli O157:H7 str. EC4024
MQPSRNFDDL
KF
S
SI
H
R
RI
LLWG
SG
GP
F
LDGY
I
L
VM
IGVAL
E
QLTPA
LK
L
DA
D
WI
G
LL
G
AGT
L
A
GLFVG
TS
LF
GYISD
KV
GRRK
M
F
L
ID
I
I
A
IGV
I
S
VATM
FV
SS
P
VE
L
L
VM
R
V
LIGI
V
IGADY
P
IA
T
S
MI
TEFS
S
T
R
Q
R
A
FSISFIA
--------
AM
W
Y
VG
ATC
A
D
L
VG
-
YWLYDVEGG
WRWML
G
SAAIP
C
LLI
LIG
R
F
EL
--------------------
PESPRWLLRKGR
V
K
E
C
E
EM
M
I
K
L
FG
EP
V
AFDE
EQ
PQQ
T
-
-
R
F
R
-----
--
--------------
D
LF
NR
R
HF
PFV
LF
VAAIWT
C
Q
--
VIP
M
F
A
IYT
F
G
P
Q
I
VGLL
GL
G
V
G
K
N
A
ALG
N
VVIS
L
FF
MLG
C
-----
I
PP
M
L
WL
N
TAG
RR
PL
L
I
GS
F
AM
M
TLA
LAVLG
L
IP
D
M
G
IW
--------
LVVM
A
F
A
-
VY
AF
F
S
GG
PG
NL
QW
LYP
N
ELFPTDIR
AS
A
VG
V
IM
S
LSRIG
T
I
VST
WA
LP
I
------
F
I
N
N
YG
-
I
S
N
TML
M
GA
G
I
S
L
F
GL
L
IS
VA
FAPETR
G
MSL
AQT
SN
M
TIRGQRMG
fig|444449.5.peg.3959
Escherichia coli O157:H7 str. EC4042
MQPSRNFDDL
KF
S
SI
H
R
RI
LLWG
SG
GP
F
LDGY
I
L
VM
IGVAL
E
QLTPA
LK
L
DA
D
WI
G
LL
G
AGT
L
A
GLFVG
TS
LF
GYISD
KV
GRRK
M
F
L
ID
I
I
A
IGV
I
S
VATM
FV
SS
P
VE
L
L
VM
R
V
LIGI
V
IGADY
P
IA
T
S
MI
TEFS
S
T
R
Q
R
A
FSISFIA
--------
AM
W
Y
VG
ATC
A
D
L
VG
-
YWLYDVEGG
WRWML
G
SAAIP
C
LLI
LIG
R
F
EL
--------------------
PESPRWLLRKGR
V
K
E
C
E
EM
M
I
K
L
FG
EP
V
AFDE
EQ
PQQ
T
-
-
R
F
R
-----
--
--------------
D
LF
NR
R
HF
PFV
LF
VAAIWT
C
Q
--
VIP
M
F
A
IYT
F
G
P
Q
I
VGLL
GL
G
V
G
K
N
A
ALG
N
VVIS
L
FF
MLG
C
-----
I
PP
M
L
WL
N
TAG
RR
PL
L
I
GS
F
AM
M
TLA
LAVLG
L
IP
D
M
G
IW
--------
LVVM
A
F
A
-
VY
AF
F
S
GG
PG
NL
QW
LYP
N
ELFPTDIR
AS
A
VG
V
IM
S
LSRIG
T
I
VST
WA
LP
I
------
F
I
N
N
YG
-
I
S
N
TML
M
GA
G
I
S
L
F
GL
L
IS
VA
FAPETR
G
MSL
AQT
SN
M
TIRGQRMG
fig|444448.5.peg.2719
Escherichia coli O157:H7 str. EC4045
MQPSRNFDDL
KF
S
SI
H
R
RI
LLWG
SG
GP
F
LDGY
I
L
VM
IGVAL
E
QLTPA
LK
L
DA
D
WI
G
LL
G
AGT
L
A
GLFVG
TS
LF
GYISD
KV
GRRK
M
F
L
ID
I
I
A
IGV
I
S
VATM
FV
SS
P
VE
L
L
VM
R
V
LIGI
V
IGADY
P
IA
T
S
MI
TEFS
S
T
R
Q
R
A
FSISFIA
--------
AM
W
Y
VG
ATC
A
D
L
VG
-
YWLYDVEGG
WRWML
G
SAAIP
C
LLI
LIG
R
F
EL
--------------------
PESPRWLLRKGR
V
K
E
C
E
EM
M
I
K
L
FG
EP
V
AFDE
EQ
PQQ
T
-
-
R
F
R
-----
--
--------------
D
LF
NR
R
HF
PFV
LF
VAAIWT
C
Q
--
VIP
M
F
A
IYT
F
G
P
Q
I
VGLL
GL
G
V
G
K
N
A
ALG
N
VVIS
L
FF
MLG
C
-----
I
PP
M
L
WL
N
TAG
RR
PL
L
I
GS
F
AM
M
TLA
LAVLG
L
IP
D
M
G
IW
--------
LVVM
A
F
A
-
VY
AF
F
S
GG
PG
NL
QW
LYP
N
ELFPTDIR
AS
A
VG
V
IM
S
LSRIG
T
I
VST
WA
LP
I
------
F
I
N
N
YG
-
I
S
N
TML
M
GA
G
I
S
L
F
GL
L
IS
VA
FAPETR
G
MSL
AQT
SN
M
TIRGQRMG
fig|444453.5.peg.3155
Escherichia coli O157:H7 str. EC4076
MQPSRNFDDL
KF
S
SI
H
R
RI
LLWG
SG
GP
F
LDGY
I
L
VM
IGVAL
E
QLTPA
LK
L
DA
D
WI
G
LL
G
AGT
L
A
GLFVG
TS
LF
GYISD
KV
GRRK
M
F
L
ID
I
I
A
IGV
I
S
VATM
FV
SS
P
VE
L
L
VM
R
V
LIGI
V
IGADY
P
IA
T
S
MI
TEFS
S
T
R
Q
R
A
FSISFIA
--------
AM
W
Y
VG
ATC
A
D
L
VG
-
YWLYDVEGG
WRWML
G
SAAIP
C
LLI
LIG
R
F
EL
--------------------
PESPRWLLRKGR
V
K
E
C
E
EM
M
I
K
L
FG
EP
V
AFDE
EQ
PQQ
T
-
-
R
F
R
-----
--
--------------
D
LF
NR
R
HF
PFV
LF
VAAIWT
C
Q
--
VIP
M
F
A
IYT
F
G
P
Q
I
VGLL
GL
G
V
G
K
N
A
ALG
N
VVIS
L
FF
MLG
C
-----
I
PP
M
L
WL
N
TAG
RR
PL
L
I
GS
F
AM
M
TLA
LAVLG
L
IP
D
M
G
IW
--------
LVVM
A
F
A
-
VY
AF
F
S
GG
PG
NL
QW
LYP
N
ELFPTDIR
AS
A
VG
V
IM
S
LSRIG
T
I
VST
WA
LP
I
------
F
I
N
N
YG
-
I
S
N
TML
M
GA
G
I
S
L
F
GL
L
IS
VA
FAPETR
G
MSL
AQT
SN
M
TIRGQRMG
fig|444452.5.peg.4588
Escherichia coli O157:H7 str. EC4113
MQPSRNFDDL
KF
S
SI
H
R
RI
LLWG
SG
GP
F
LDGY
I
L
VM
IGVAL
E
QLTPA
LK
L
DA
D
WI
G
LL
G
AGT
L
A
GLFVG
TS
LF
GYISD
KV
GRRK
M
F
L
ID
I
I
A
IGV
I
S
VATM
FV
SS
P
VE
L
L
VM
R
V
LIGI
V
IGADY
P
IA
T
S
MI
TEFS
S
T
R
Q
R
A
FSISFIA
--------
AM
W
Y
VG
ATC
A
D
L
VG
-
YWLYDVEGG
WRWML
G
SAAIP
C
LLI
LIG
R
F
EL
--------------------
PESPRWLLRKGR
V
K
E
C
E
EM
M
I
K
L
FG
EP
V
AFDE
EQ
PQQ
T
-
-
R
F
R
-----
--
--------------
D
LF
NR
R
HF
PFV
LF
VAAIWT
C
Q
--
VIP
M
F
A
IYT
F
G
P
Q
I
VGLL
GL
G
V
G
K
N
A
ALG
N
VVIS
L
FF
MLG
C
-----
I
PP
M
L
WL
N
TAG
RR
PL
L
I
GS
F
AM
M
TLA
LAVLG
L
IP
D
M
G
IW
--------
LVVM
A
F
A
-
VY
AF
F
S
GG
PG
NL
QW
LYP
N
ELFPTDIR
AS
A
VG
V
IM
S
LSRIG
T
I
VST
WA
LP
I
------
F
I
N
N
YG
-
I
S
N
TML
M
GA
G
I
S
L
F
GL
L
IS
VA
FAPETR
G
MSL
AQT
SN
M
TIRGQRMG
fig|444450.8.peg.189
Escherichia coli O157:H7 str. EC4115
MQPSRNFDDL
KF
S
SI
H
R
RI
LLWG
SG
GP
F
LDGY
I
L
VM
IGVAL
E
QLTPA
LK
L
DA
D
WI
G
LL
G
AGT
L
A
GLFVG
TS
LF
GYISD
KV
GRRK
M
F
L
ID
I
I
A
IGV
I
S
VATM
FV
SS
P
VE
L
L
VM
R
V
LIGI
V
IGADY
P
IA
T
S
MI
TEFS
S
T
R
Q
R
A
FSISFIA
--------
AM
W
Y
VG
ATC
A
D
L
VG
-
YWLYDVEGG
WRWML
G
SAAIP
C
LLI
LIG
R
F
EL
--------------------
PESPRWLLRKGR
V
K
E
C
E
EM
M
I
K
L
FG
EP
V
AFDE
EQ
PQQ
T
-
-
R
F
R
-----
--
--------------
D
LF
NR
R
HF
PFV
LF
VAAIWT
C
Q
--
VIP
M
F
A
IYT
F
G
P
Q
I
VGLL
GL
G
V
G
K
N
A
ALG
N
VVIS
L
FF
MLG
C
-----
I
PP
M
L
WL
N
TAG
RR
PL
L
I
GS
F
AM
M
TLA
LAVLG
L
IP
D
M
G
IW
--------
LVVM
A
F
A
-
VY
AF
F
S
GG
PG
NL
QW
LYP
N
ELFPTDIR
AS
A
VG
V
IM
S
LSRIG
T
I
VST
WA
LP
I
------
F
I
N
N
YG
-
I
S
N
TML
M
GA
G
I
S
L
F
GL
L
IS
VA
FAPETR
G
MSL
AQT
SN
M
TIRGQRMG
fig|444451.5.peg.4441
Escherichia coli O157:H7 str. EC4196
MQPSRNFDDL
KF
S
SI
H
R
RI
LLWG
SG
GP
F
LDGY
I
L
VM
IGVAL
E
QLTPA
LK
L
DA
D
WI
G
LL
G
AGT
L
A
GLFVG
TS
LF
GYISD
KV
GRRK
M
F
L
ID
I
I
A
IGV
I
S
VATM
FV
SS
P
VE
L
L
VM
R
V
LIGI
V
IGADY
P
IA
T
S
MI
TEFS
S
T
R
Q
R
A
FSISFIA
--------
AM
W
Y
VG
ATC
A
D
L
VG
-
YWLYDVEGG
WRWML
G
SAAIP
C
LLI
LIG
R
F
EL
--------------------
PESPRWLLRKGR
V
K
E
C
E
EM
M
I
K
L
FG
EP
V
AFDE
EQ
PQQ
T
-
-
R
F
R
-----
--
--------------
D
LF
NR
R
HF
PFV
LF
VAAIWT
C
Q
--
VIP
M
F
A
IYT
F
G
P
Q
I
VGLL
GL
G
V
G
K
N
A
ALG
N
VVIS
L
FF
MLG
C
-----
I
PP
M
L
WL
N
TAG
RR
PL
L
I
GS
F
AM
M
TLA
LAVLG
L
IP
D
M
G
IW
--------
LVVM
A
F
A
-
VY
AF
F
S
GG
PG
NL
QW
LYP
N
ELFPTDIR
AS
A
VG
V
IM
S
LSRIG
T
I
VST
WA
LP
I
------
F
I
N
N
YG
-
I
S
N
TML
M
GA
G
I
S
L
F
GL
L
IS
VA
FAPETR
G
MSL
AQT
SN
M
TIRGQRMG
fig|444447.5.peg.2886
Escherichia coli O157:H7 str. EC4206
MQPSRNFDDL
KF
S
SI
H
R
RI
LLWG
SG
GP
F
LDGY
I
L
VM
IGVAL
E
QLTPA
LK
L
DA
D
WI
G
LL
G
AGT
L
A
GLFVG
TS
LF
GYISD
KV
GRRK
M
F
L
ID
I
I
A
IGV
I
S
VATM
FV
SS
P
VE
L
L
VM
R
V
LIGI
V
IGADY
P
IA
T
S
MI
TEFS
S
T
R
Q
R
A
FSISFIA
--------
AM
W
Y
VG
ATC
A
D
L
VG
-
YWLYDVEGG
WRWML
G
SAAIP
C
LLI
LIG
R
F
EL
--------------------
PESPRWLLRKGR
V
K
E
C
E
EM
M
I
K
L
FG
EP
V
AFDE
EQ
PQQ
T
-
-
R
F
R
-----
--
--------------
D
LF
NR
R
HF
PFV
LF
VAAIWT
C
Q
--
VIP
M
F
A
IYT
F
G
P
Q
I
VGLL
GL
G
V
G
K
N
A
ALG
N
VVIS
L
FF
MLG
C
-----
I
PP
M
L
WL
N
TAG
RR
PL
L
I
GS
F
AM
M
TLA
LAVLG
L
IP
D
M
G
IW
--------
LVVM
A
F
A
-
VY
AF
F
S
GG
PG
NL
QW
LYP
N
ELFPTDIR
AS
A
VG
V
IM
S
LSRIG
T
I
VST
WA
LP
I
------
F
I
N
N
YG
-
I
S
N
TML
M
GA
G
I
S
L
F
GL
L
IS
VA
FAPETR
G
MSL
AQT
SN
M
TIRGQRMG
fig|478004.5.peg.3571
Escherichia coli O157:H7 str. EC4401
MQPSRNFDDL
KF
S
SI
H
R
RI
LLWG
SG
GP
F
LDGY
I
L
VM
IGVAL
E
QLTPA
LK
L
DA
D
WI
G
LL
G
AGT
L
A
GLFVG
TS
LF
GYISD
KV
GRRK
M
F
L
ID
I
I
A
IGV
I
S
VATM
FV
SS
P
VE
L
L
VM
R
V
LIGI
V
IGADY
P
IA
T
S
MI
TEFS
S
T
R
Q
R
A
FSISFIA
--------
AM
W
Y
VG
ATC
A
D
L
VG
-
YWLYDVEGG
WRWML
G
SAAIP
C
LLI
LIG
R
F
EL
--------------------
PESPRWLLRKGR
V
K
E
C
E
EM
M
I
K
L
FG
EP
V
AFDE
EQ
PQQ
T
-
-
R
F
R
-----
--
--------------
D
LF
NR
R
HF
PFV
LF
VAAIWT
C
Q
--
VIP
M
F
A
IYT
F
G
P
Q
I
VGLL
GL
G
V
G
K
N
A
ALG
N
VVIS
L
FF
MLG
C
-----
I
PP
M
L
WL
N
TAG
RR
PL
L
I
GS
F
AM
M
TLA
LAVLG
L
IP
D
M
G
IW
--------
LVVM
A
F
A
-
VY
AF
F
S
GG
PG
NL
QW
LYP
N
ELFPTDIR
AS
A
VG
V
IM
S
LSRIG
T
I
VST
WA
LP
I
------
F
I
N
N
YG
-
I
S
N
TML
M
GA
G
I
S
L
F
GL
L
IS
VA
FAPETR
G
MSL
AQT
SN
M
TIRGQRMG
fig|478005.5.peg.925
Escherichia coli O157:H7 str. EC4486
MQPSRNFDDL
KF
S
SI
H
R
RI
LLWG
SG
GP
F
LDGY
I
L
VM
IGVAL
E
QLTPA
LK
L
DA
D
WI
G
LL
G
AGT
L
A
GLFVG
TS
LF
GYISD
KV
GRRK
M
F
L
ID
I
I
A
IGV
I
S
VATM
FV
SS
P
VE
L
L
VM
R
V
LIGI
V
IGADY
P
IA
T
S
MI
TEFS
S
T
R
Q
R
A
FSISFIA
--------
AM
W
Y
VG
ATC
A
D
L
VG
-
YWLYDVEGG
WRWML
G
SAAIP
C
LLI
LIG
R
F
EL
--------------------
PESPRWLLRKGR
V
K
E
C
E
EM
M
I
K
L
FG
EP
V
AFDE
EQ
PQQ
T
-
-
R
F
R
-----
--
--------------
D
LF
NR
R
HF
PFV
LF
VAAIWT
C
Q
--
VIP
M
F
A
IYT
F
G
P
Q
I
VGLL
GL
G
V
G
K
N
A
ALG
N
VVIS
L
FF
MLG
C
-----
I
PP
M
L
WL
N
TAG
RR
PL
L
I
GS
F
AM
M
TLA
LAVLG
L
IP
D
M
G
IW
--------
LVVM
A
F
A
-
VY
AF
F
S
GG
PG
NL
QW
LYP
N
ELFPTDIR
AS
A
VG
V
IM
S
LSRIG
T
I
VST
WA
LP
I
------
F
I
N
N
YG
-
I
S
N
TML
M
GA
G
I
S
L
F
GL
L
IS
VA
FAPETR
G
MSL
AQT
SN
M
TIRGQRMG
fig|478006.5.peg.3239
Escherichia coli O157:H7 str. EC4501
MQPSRNFDDL
KF
S
SI
H
R
RI
LLWG
SG
GP
F
LDGY
I
L
VM
IGVAL
E
QLTPA
LK
L
DA
D
WI
G
LL
G
AGT
L
A
GLFVG
TS
LF
GYISD
KV
GRRK
M
F
L
ID
I
I
A
IGV
I
S
VATM
FV
SS
P
VE
L
L
VM
R
V
LIGI
V
IGADY
P
IA
T
S
MI
TEFS
S
T
R
Q
R
A
FSISFIA
--------
AM
W
Y
VG
ATC
A
D
L
VG
-
YWLYDVEGG
WRWML
G
SAAIP
C
LLI
LIG
R
F
EL
--------------------
PESPRWLLRKGR
V
K
E
C
E
EM
M
I
K
L
FG
EP
V
AFDE
EQ
PQQ
T
-
-
R
F
R
-----
--
--------------
D
LF
NR
R
HF
PFV
LF
VAAIWT
C
Q
--
VIP
M
F
A
IYT
F
G
P
Q
I
VGLL
GL
G
V
G
K
N
A
ALG
N
VVIS
L
FF
MLG
C
-----
I
PP
M
L
WL
N
TAG
RR
PL
L
I
GS
F
AM
M
TLA
LAVLG
L
IP
D
M
G
IW
--------
LVVM
A
F
A
-
VY
AF
F
S
GG
PG
NL
QW
LYP
N
ELFPTDIR
AS
A
VG
V
IM
S
LSRIG
T
I
VST
WA
LP
I
------
F
I
N
N
YG
-
I
S
N
TML
M
GA
G
I
S
L
F
GL
L
IS
VA
FAPETR
G
MSL
AQT
SN
M
TIRGQRMG
fig|478007.5.peg.4532
Escherichia coli O157:H7 str. EC508
MQPSRNFDDL
KF
S
SI
H
R
RI
LLWG
SG
GP
F
LDGY
I
L
VM
IGVAL
E
QLTPA
LK
L
DA
D
WI
G
LL
G
AGT
L
A
GLFVG
TS
LF
GYISD
KV
GRRK
M
F
L
ID
I
I
A
IGV
I
S
VATM
FV
SS
P
VE
L
L
VM
R
V
LIGI
V
IGADY
P
IA
T
S
MI
TEFS
S
T
R
Q
R
A
FSISFIA
--------
AM
W
Y
VG
ATC
A
D
L
VG
-
YWLYDVEGG
WRWML
G
SAAIP
C
LLI
LIG
R
F
EL
--------------------
PESPRWLLRKGR
V
K
E
C
E
EM
M
I
K
L
FG
EP
V
AFDE
EQ
PQQ
T
-
-
R
F
R
-----
--
--------------
D
LF
NR
R
HF
PFV
LF
VAAIWT
C
Q
--
VIP
M
F
A
IYT
F
G
P
Q
I
VGLL
GL
G
V
G
K
N
A
ALG
N
VVIS
L
FF
MLG
C
-----
I
PP
M
L
WL
N
TAG
RR
PL
L
I
GS
F
AM
M
TLA
LAVLG
L
IP
D
M
G
IW
--------
LVVM
A
F
A
-
VY
AF
F
S
GG
PG
NL
QW
LYP
N
ELFPTDIR
AS
A
VG
V
IM
S
LSRIG
T
I
VST
WA
LP
I
------
F
I
N
N
YG
-
I
S
N
TML
M
GA
G
I
S
L
F
GL
L
IS
VA
FAPETR
G
MSL
AQT
SN
M
TIRGQRMG
fig|386585.9.peg.147
Escherichia coli O157:H7 str. Sakai
MQPSRNFDDL
KF
S
SI
H
R
RI
LLWG
SG
GP
F
LDGY
I
L
VM
IGVAL
E
QLTPA
LK
L
DA
D
WI
G
LL
G
AGT
L
A
GLFVG
TS
LF
GYISD
KV
GRRK
M
F
L
ID
I
I
A
IGV
I
S
VATM
FV
SS
P
VE
L
L
VM
R
V
LIGI
V
IGADY
P
IA
T
S
MI
TEFS
S
T
R
Q
R
A
FSISFIA
--------
AM
W
Y
VG
ATC
A
D
L
VG
-
YWLYDVEGG
WRWML
G
SAAIP
C
LLI
LIG
R
F
EL
--------------------
PESPRWLLRKGR
V
K
E
C
E
EM
M
I
K
L
FG
EP
V
AFDE
EQ
PQQ
T
-
-
R
F
R
-----
--
--------------
D
LF
NR
R
HF
PFV
LF
VAAIWT
C
Q
--
VIP
M
F
A
IYT
F
G
P
Q
I
VGLL
GL
G
V
G
K
N
A
ALG
N
VVIS
L
FF
MLG
C
-----
I
PP
M
L
WL
N
TAG
RR
PL
L
I
GS
F
AM
M
TLA
LAVLG
L
IP
D
M
G
IW
--------
LVVM
A
F
A
-
VY
AF
F
S
GG
PG
NL
QW
LYP
N
ELFPTDIR
AS
A
VG
V
IM
S
LSRIG
T
I
VST
WA
LP
I
------
F
I
N
N
YG
-
I
S
N
TML
M
GA
G
I
S
L
F
GL
L
IS
VA
FAPETR
G
MSL
AQT
SN
M
TIRGQRMG
fig|544404.4.peg.51
Escherichia coli O157:H7 str. TW14359
MQPSRNFDDL
KF
S
SI
H
R
RI
LLWG
SG
GP
F
LDGY
I
L
VM
IGVAL
E
QLTPA
LK
L
DA
D
WI
G
LL
G
AGT
L
A
GLFVG
TS
LF
GYISD
KV
GRRK
M
F
L
ID
I
I
A
IGV
I
S
VATM
FV
SS
P
VE
L
L
VM
R
V
LIGI
V
IGADY
P
IA
T
S
MI
TEFS
S
T
R
Q
R
A
FSISFIA
--------
AM
W
Y
VG
ATC
A
D
L
VG
-
YWLYDVEGG
WRWML
G
SAAIP
C
LLI
LIG
R
F
EL
--------------------
PESPRWLLRKGR
V
K
E
C
E
EM
M
I
K
L
FG
EP
V
AFDE
EQ
PQQ
T
-
-
R
F
R
-----
--
--------------
D
LF
NR
R
HF
PFV
LF
VAAIWT
C
Q
--
VIP
M
F
A
IYT
F
G
P
Q
I
VGLL
GL
G
V
G
K
N
A
ALG
N
VVIS
L
FF
MLG
C
-----
I
PP
M
L
WL
N
TAG
RR
PL
L
I
GS
F
AM
M
TLA
LAVLG
L
IP
D
M
G
IW
--------
LVVM
A
F
A
-
VY
AF
F
S
GG
PG
NL
QW
LYP
N
ELFPTDIR
AS
A
VG
V
IM
S
LSRIG
T
I
VST
WA
LP
I
------
F
I
N
N
YG
-
I
S
N
TML
M
GA
G
I
S
L
F
GL
L
IS
VA
FAPETR
G
MSL
AQT
SN
M
TIRGQRMG
fig|502346.5.peg.1216
Escherichia coli O157:H7 str. TW14588
MQPSRNFDDL
KF
S
SI
H
R
RI
LLWG
SG
GP
F
LDGY
I
L
VM
IGVAL
E
QLTPA
LK
L
DA
D
WI
G
LL
G
AGT
L
A
GLFVG
TS
LF
GYISD
KV
GRRK
M
F
L
ID
I
I
A
IGV
I
S
VATM
FV
SS
P
VE
L
L
VM
R
V
LIGI
V
IGADY
P
IA
T
S
MI
TEFS
S
T
R
Q
R
A
FSISFIA
--------
AM
W
Y
VG
ATC
A
D
L
VG
-
YWLYDVEGG
WRWML
G
SAAIP
C
LLI
LIG
R
F
EL
--------------------
PESPRWLLRKGR
V
K
E
C
E
EM
M
I
K
L
FG
EP
V
AFDE
EQ
PQQ
T
-
-
R
F
R
-----
--
--------------
D
LF
NR
R
HF
PFV
LF
VAAIWT
C
Q
--
VIP
M
F
A
IYT
F
G
P
Q
I
VGLL
GL
G
V
G
K
N
A
ALG
N
VVIS
L
FF
MLG
C
-----
I
PP
M
L
WL
N
TAG
RR
PL
L
I
GS
F
AM
M
TLA
LAVLG
L
IP
D
M
G
IW
--------
LVVM
A
F
A
-
VY
AF
F
S
GG
PG
NL
QW
LYP
N
ELFPTDIR
AS
A
VG
V
IM
S
LSRIG
T
I
VST
WA
LP
I
------
F
I
N
N
YG
-
I
S
N
TML
M
GA
G
I
S
L
F
GL
L
IS
VA
FAPETR
G
MSL
AQT
SN
M
TIRGQRMG
fig|701177.3.peg.48
Escherichia coli O55:H7 str. CB9615
MQPSRNFDDL
KF
S
SI
H
R
RI
LLWG
SG
GP
F
LDGY
I
L
VM
IGVAL
E
QLTPA
LK
L
DA
D
WI
G
LL
G
AGT
L
A
GLFVG
TS
LF
GYISD
KV
GRRK
M
F
L
ID
I
I
A
IGV
I
S
VATM
FV
SS
P
VE
L
L
VM
R
V
LIGI
V
IGADY
P
IA
T
S
MI
TEFS
S
T
R
Q
R
A
FSISFIA
--------
AM
W
Y
VG
ATC
A
D
L
VG
-
YWLYDVEGG
WRWML
G
SAAIP
C
LLI
LIG
R
F
EL
--------------------
PESPRWLLRKGR
V
K
E
C
E
EM
M
I
K
L
FG
EP
V
AFDE
EQ
PQQ
T
-
-
R
F
R
-----
--
--------------
D
LF
NR
R
HF
PFV
LF
VAAIWT
C
Q
--
VIP
M
F
A
IYT
F
G
P
Q
I
VGLL
GL
G
V
G
K
N
A
ALG
N
VVIS
L
FF
MLG
C
-----
I
PP
M
L
WL
N
TAG
RR
PL
L
I
GS
F
AM
M
TLA
LAVLG
L
IP
D
M
G
IW
--------
LVVM
A
F
A
-
VY
AF
F
S
GG
PG
NL
QW
LYP
N
ELFPTDIR
AS
A
VG
V
IM
S
LSRIG
T
I
VST
WA
LP
I
------
F
I
N
N
YG
-
I
S
N
TML
M
GA
G
I
S
L
F
GL
L
IS
VA
FAPETR
G
MSL
AQT
SN
M
TIRGQRMG
fig|340184.3.peg.4269
Escherichia coli B7A
MQPSRNFDDL
KF
S
SI
H
R
RI
LLWG
SG
GP
F
LDGYVL
VM
IGVAL
E
QLTPA
LK
L
DA
D
WI
G
LL
G
AGT
L
A
GLFVG
TS
LF
GYISD
KV
GRRK
M
F
L
ID
I
I
A
IGV
I
S
VATM
FV
SS
P
VE
L
L
VM
R
V
LIGI
V
IGADY
P
IA
T
S
MI
TEFS
S
T
R
Q
R
A
FSISFIA
--------
AM
W
Y
VG
ATC
A
D
L
VG
-
YWLYDVEGG
WRWML
G
SAAIP
C
LLI
LIG
R
F
EL
--------------------
PESPRWLLRKGR
V
K
E
C
E
EM
M
I
K
L
FG
EP
V
AFDE
EQ
PQQ
T
-
-
R
F
R
-----
--
--------------
D
LF
NR
R
HF
PFV
LF
VAAIWT
C
Q
--
VIP
M
F
A
IYT
F
G
P
Q
I
VGLL
GL
G
V
G
K
N
A
ALG
N
VVIS
L
FF
MLG
C
-----
I
PP
M
L
WL
N
TAG
RR
PL
L
I
GS
F
AM
M
TLA
LAVLG
L
IP
D
M
G
IW
--------
LVV
V
A
F
A
-
VY
AF
F
S
GG
PG
NL
QW
LYP
N
ELFPTDIR
AS
A
VG
V
IM
S
LSRIG
T
I
VST
WA
LP
I
------
F
I
N
N
YG
-
I
S
N
TML
M
GA
G
I
S
L
F
GL
L
IS
VA
FAPETR
G
MSL
AQT
SN
M
TIRGQRMG
fig|340184.6.peg.4476
Escherichia coli B7A
MQPSRNFDDL
KF
S
SI
H
R
RI
LLWG
SG
GP
F
LDGYVL
VM
IGVAL
E
QLTPA
LK
L
DA
D
WI
G
LL
G
AGT
L
A
GLFVG
TS
LF
GYISD
KV
GRRK
M
F
L
ID
I
I
A
IGV
I
S
VATM
FV
SS
P
VE
L
L
VM
R
V
LIGI
V
IGADY
P
IA
T
S
MI
TEFS
S
T
R
Q
R
A
FSISFIA
--------
AM
W
Y
VG
ATC
A
D
L
VG
-
YWLYDVEGG
WRWML
G
SAAIP
C
LLI
LIG
R
F
EL
--------------------
PESPRWLLRKGR
V
K
E
C
E
EM
M
I
K
L
FG
EP
V
AFDE
EQ
PQQ
T
-
-
R
F
R
-----
--
--------------
D
LF
NR
R
HF
PFV
LF
VAAIWT
C
Q
--
VIP
M
F
A
IYT
F
G
P
Q
I
VGLL
GL
G
V
G
K
N
A
ALG
N
VVIS
L
FF
MLG
C
-----
I
PP
M
L
WL
N
TAG
RR
PL
L
I
GS
F
AM
M
TLA
LAVLG
L
IP
D
M
G
IW
--------
LVV
V
A
F
A
-
VY
AF
F
S
GG
PG
NL
QW
LYP
N
ELFPTDIR
AS
A
VG
V
IM
S
LSRIG
T
I
VST
WA
LP
I
------
F
I
N
N
YG
-
I
S
N
TML
M
GA
G
I
S
L
F
GL
L
IS
VA
FAPETR
G
MSL
AQT
SN
M
TIRGQRMG
fig|637912.3.peg.4534
Escherichia coli OP50
MQPSRNFDDL
KF
S
SI
H
R
RI
LLWG
SG
GP
F
LDGYVL
VM
IGVAL
E
QLTPA
LK
L
DA
D
WI
G
LL
G
AGT
L
A
GLFVG
TS
LF
GYISD
KV
GRRK
M
F
L
ID
I
I
A
IGV
I
S
VATM
FV
SS
P
VE
L
L
VM
R
V
LIGI
V
IGADY
P
IA
T
S
MI
TEFS
S
T
R
Q
R
A
FSISFIA
--------
AM
W
Y
VG
ATC
A
D
L
VG
-
YWLYDVEGG
WRWML
G
SAAIP
C
LLI
LIG
R
F
EL
--------------------
PESPRWLLRKGR
V
K
E
C
E
EM
M
I
K
L
FG
EP
V
AFDE
EQ
PQQ
T
-
-
R
F
R
-----
--
--------------
D
LF
NR
R
HF
PFV
LF
VAAIWT
C
Q
--
VIP
M
F
A
IYT
F
G
P
Q
I
VGLL
GL
G
V
G
K
N
A
ALG
N
VVIS
L
FF
MLG
C
-----
I
PP
M
L
WL
N
TAG
RR
PL
L
I
GS
F
AM
M
TLA
LAVLG
L
IP
D
M
G
IW
--------
LVVM
A
F
A
-
VY
AF
F
S
GG
PG
NL
QW
LYP
N
ELFPTDIR
AS
A
VG
V
IM
S
LSRIG
T
I
VST
WA
LP
I
------
F
I
N
N
YG
-
I
S
N
TML
M
G
V
G
I
S
L
F
GL
L
IS
VA
FAPETR
G
MSL
AQT
SN
M
TIRGQRMG
fig|216592.1.peg.4369
Escherichia coli 042
MQPSRNFDDL
KF
S
SI
H
R
RI
LLWG
SG
GP
F
LDGYVL
VM
IGVAL
E
QLTPA
LK
L
DA
D
WI
G
LL
G
AGT
L
A
GLFVG
TS
LF
GYISD
KV
GRRK
M
F
L
ID
I
I
A
IGV
I
S
VATM
FV
SS
P
VE
L
L
VM
R
V
LIGI
V
IGADY
P
IA
T
S
MI
TEFS
S
T
R
Q
R
A
FSISFIA
--------
AM
W
Y
VG
ATC
A
D
L
VG
-
YWLYDVEGG
WRWML
G
SAAIP
C
LLI
LIG
R
F
EL
--------------------
PESPRWLLRKGR
V
K
E
C
E
EM
M
I
K
L
FG
EP
V
AFEE
EQ
PQQ
T
-
-
R
F
R
-----
--
--------------
D
LF
NR
R
HF
PFV
LF
VAAIWT
C
Q
--
VIP
M
F
A
IYT
F
G
P
Q
I
VGLL
GL
G
V
G
K
N
A
ALG
N
VVIS
L
FF
MLG
C
-----
I
PP
M
L
WL
N
TAG
RR
PL
L
I
GS
F
AM
M
TLA
LAVLG
L
IP
D
M
G
IW
--------
LVVM
A
F
A
-
VY
AF
F
S
GG
PG
NL
QW
LYP
N
ELFPTDIR
AS
A
VG
V
IM
S
LSRIG
T
I
VST
WA
LP
I
------
F
I
N
N
YG
-
I
S
N
TML
M
GA
G
I
S
L
F
GL
L
IS
VA
FAPETR
G
MSL
AQT
SN
M
TIRGQRMG
fig|216592.3.peg.53
Escherichia coli 042
MQPSRNFDDL
KF
S
SI
H
R
RI
LLWG
SG
GP
F
LDGYVL
VM
IGVAL
E
QLTPA
LK
L
DA
D
WI
G
LL
G
AGT
L
A
GLFVG
TS
LF
GYISD
KV
GRRK
M
F
L
ID
I
I
A
IGV
I
S
VATM
FV
SS
P
VE
L
L
VM
R
V
LIGI
V
IGADY
P
IA
T
S
MI
TEFS
S
T
R
Q
R
A
FSISFIA
--------
AM
W
Y
VG
ATC
A
D
L
VG
-
YWLYDVEGG
WRWML
G
SAAIP
C
LLI
LIG
R
F
EL
--------------------
PESPRWLLRKGR
V
K
E
C
E
EM
M
I
K
L
FG
EP
V
AFEE
EQ
PQQ
T
-
-
R
F
R
-----
--
--------------
D
LF
NR
R
HF
PFV
LF
VAAIWT
C
Q
--
VIP
M
F
A
IYT
F
G
P
Q
I
VGLL
GL
G
V
G
K
N
A
ALG
N
VVIS
L
FF
MLG
C
-----
I
PP
M
L
WL
N
TAG
RR
PL
L
I
GS
F
AM
M
TLA
LAVLG
L
IP
D
M
G
IW
--------
LVVM
A
F
A
-
VY
AF
F
S
GG
PG
NL
QW
LYP
N
ELFPTDIR
AS
A
VG
V
IM
S
LSRIG
T
I
VST
WA
LP
I
------
F
I
N
N
YG
-
I
S
N
TML
M
GA
G
I
S
L
F
GL
L
IS
VA
FAPETR
G
MSL
AQT
SN
M
TIRGQRMG
fig|670897.3.peg.1858
Escherichia coli 2362-75
MQPSRNFDDL
KF
S
SI
H
R
RI
LLWG
SG
GP
F
LDGYVL
VM
IGVAL
E
QLTPA
LK
L
DA
D
WI
G
LL
G
AGT
L
A
GLFVG
TS
LF
GYISD
KV
GRRK
M
F
L
ID
I
I
A
IGV
I
S
VATM
FV
SS
P
VE
L
L
VM
R
V
LIGI
V
IGADY
P
IA
T
S
MI
TEFS
S
T
R
Q
R
A
FSISFIA
--------
AM
W
Y
VG
ATC
A
D
L
VG
-
YWLYDVEGG
WRWML
G
SAAIP
C
LLI
LIG
R
F
EL
--------------------
PESPRWLLRKGR
V
K
E
C
E
EM
M
I
K
L
FG
EP
V
AFEE
EQ
PQQ
T
-
-
R
F
R
-----
--
--------------
D
LF
NR
R
HF
PFV
LF
VAAIWT
C
Q
--
VIP
M
F
A
IYT
F
G
P
Q
I
VGLL
GL
G
V
G
K
N
A
ALG
N
VVIS
L
FF
MLG
C
-----
I
PP
M
L
WL
N
TAG
RR
PL
L
I
GS
F
AM
M
TLA
LAVLG
L
IP
D
M
G
IW
--------
LVVM
A
F
A
-
VY
AF
F
S
GG
PG
NL
QW
LYP
N
ELFPTDIR
AS
A
VG
V
IM
S
LSRIG
T
I
VST
WA
LP
I
------
F
I
N
N
YG
-
I
S
N
TML
M
GA
G
I
S
L
F
GL
L
IS
VA
FAPETR
G
MSL
AQT
SN
M
TIRGQRMG
fig|525281.3.peg.1225
Escherichia coli 83972
MQPSRNFDDL
KF
S
SI
H
R
RI
LLWG
SG
GP
F
LDGYVL
VM
IGVAL
E
QLTPA
LK
L
DA
D
WI
G
LL
G
AGT
L
A
GLFVG
TS
LF
GYISD
KV
GRRK
M
F
L
ID
I
I
A
IGV
I
S
VATM
FV
SS
P
VE
L
L
VM
R
V
LIGI
V
IGADY
P
IA
T
S
MI
TEFS
S
T
R
Q
R
A
FSISFIA
--------
AM
W
Y
VG
ATC
A
D
L
VG
-
YWLYDVEGG
WRWML
G
SAAIP
C
LLI
LIG
R
F
EL
--------------------
PESPRWLLRKGR
V
K
E
C
E
EM
M
I
K
L
FG
EP
V
AFEE
EQ
PQQ
T
-
-
R
F
R
-----
--
--------------
D
LF
NR
R
HF
PFV
LF
VAAIWT
C
Q
--
VIP
M
F
A
IYT
F
G
P
Q
I
VGLL
GL
G
V
G
K
N
A
ALG
N
VVIS
L
FF
MLG
C
-----
I
PP
M
L
WL
N
TAG
RR
PL
L
I
GS
F
AM
M
TLA
LAVLG
L
IP
D
M
G
IW
--------
LVVM
A
F
A
-
VY
AF
F
S
GG
PG
NL
QW
LYP
N
ELFPTDIR
AS
A
VG
V
IM
S
LSRIG
T
I
VST
WA
LP
I
------
F
I
N
N
YG
-
I
S
N
TML
M
GA
G
I
S
L
F
GL
L
IS
VA
FAPETR
G
MSL
AQT
SN
M
TIRGQRMG
fig|655817.3.peg.51
Escherichia coli ABU 83972
MQPSRNFDDL
KF
S
SI
H
R
RI
LLWG
SG
GP
F
LDGYVL
VM
IGVAL
E
QLTPA
LK
L
DA
D
WI
G
LL
G
AGT
L
A
GLFVG
TS
LF
GYISD
KV
GRRK
M
F
L
ID
I
I
A
IGV
I
S
VATM
FV
SS
P
VE
L
L
VM
R
V
LIGI
V
IGADY
P
IA
T
S
MI
TEFS
S
T
R
Q
R
A
FSISFIA
--------
AM
W
Y
VG
ATC
A
D
L
VG
-
YWLYDVEGG
WRWML
G
SAAIP
C
LLI
LIG
R
F
EL
--------------------
PESPRWLLRKGR
V
K
E
C
E
EM
M
I
K
L
FG
EP
V
AFEE
EQ
PQQ
T
-
-
R
F
R
-----
--
--------------
D
LF
NR
R
HF
PFV
LF
VAAIWT
C
Q
--
VIP
M
F
A
IYT
F
G
P
Q
I
VGLL
GL
G
V
G
K
N
A
ALG
N
VVIS
L
FF
MLG
C
-----
I
PP
M
L
WL
N
TAG
RR
PL
L
I
GS
F
AM
M
TLA
LAVLG
L
IP
D
M
G
IW
--------
LVVM
A
F
A
-
VY
AF
F
S
GG
PG
NL
QW
LYP
N
ELFPTDIR
AS
A
VG
V
IM
S
LSRIG
T
I
VST
WA
LP
I
------
F
I
N
N
YG
-
I
S
N
TML
M
GA
G
I
S
L
F
GL
L
IS
VA
FAPETR
G
MSL
AQT
SN
M
TIRGQRMG
fig|405955.13.peg.50
Escherichia coli APEC O1
MQPSRNFDDL
KF
S
SI
H
R
RI
LLWG
SG
GP
F
LDGYVL
VM
IGVAL
E
QLTPA
LK
L
DA
D
WI
G
LL
G
AGT
L
A
GLFVG
TS
LF
GYISD
KV
GRRK
M
F
L
ID
I
I
A
IGV
I
S
VATM
FV
SS
P
VE
L
L
VM
R
V
LIGI
V
IGADY
P
IA
T
S
MI
TEFS
S
T
R
Q
R
A
FSISFIA
--------
AM
W
Y
VG
ATC
A
D
L
VG
-
YWLYDVEGG
WRWML
G
SAAIP
C
LLI
LIG
R
F
EL
--------------------
PESPRWLLRKGR
V
K
E
C
E
EM
M
I
K
L
FG
EP
V
AFEE
EQ
PQQ
T
-
-
R
F
R
-----
--
--------------
D
LF
NR
R
HF
PFV
LF
VAAIWT
C
Q
--
VIP
M
F
A
IYT
F
G
P
Q
I
VGLL
GL
G
V
G
K
N
A
ALG
N
VVIS
L
FF
MLG
C
-----
I
PP
M
L
WL
N
TAG
RR
PL
L
I
GS
F
AM
M
TLA
LAVLG
L
IP
D
M
G
IW
--------
LVVM
A
F
A
-
VY
AF
F
S
GG
PG
NL
QW
LYP
N
ELFPTDIR
AS
A
VG
V
IM
S
LSRIG
T
I
VST
WA
LP
I
------
F
I
N
N
YG
-
I
S
N
TML
M
GA
G
I
S
L
F
GL
L
IS
VA
FAPETR
G
MSL
AQT
SN
M
TIRGQRMG
fig|405955.9.peg.39
Escherichia coli APEC O1
MQPSRNFDDL
KF
S
SI
H
R
RI
LLWG
SG
GP
F
LDGYVL
VM
IGVAL
E
QLTPA
LK
L
DA
D
WI
G
LL
G
AGT
L
A
GLFVG
TS
LF
GYISD
KV
GRRK
M
F
L
ID
I
I
A
IGV
I
S
VATM
FV
SS
P
VE
L
L
VM
R
V
LIGI
V
IGADY
P
IA
T
S
MI
TEFS
S
T
R
Q
R
A
FSISFIA
--------
AM
W
Y
VG
ATC
A
D
L
VG
-
YWLYDVEGG
WRWML
G
SAAIP
C
LLI
LIG
R
F
EL
--------------------
PESPRWLLRKGR
V
K
E
C
E
EM
M
I
K
L
FG
EP
V
AFEE
EQ
PQQ
T
-
-
R
F
R
-----
--
--------------
D
LF
NR
R
HF
PFV
LF
VAAIWT
C
Q
--
VIP
M
F
A
IYT
F
G
P
Q
I
VGLL
GL
G
V
G
K
N
A
ALG
N
VVIS
L
FF
MLG
C
-----
I
PP
M
L
WL
N
TAG
RR
PL
L
I
GS
F
AM
M
TLA
LAVLG
L
IP
D
M
G
IW
--------
LVVM
A
F
A
-
VY
AF
F
S
GG
PG
NL
QW
LYP
N
ELFPTDIR
AS
A
VG
V
IM
S
LSRIG
T
I
VST
WA
LP
I
------
F
I
N
N
YG
-
I
S
N
TML
M
GA
G
I
S
L
F
GL
L
IS
VA
FAPETR
G
MSL
AQT
SN
M
TIRGQRMG
fig|199310.1.peg.51
Escherichia coli CFT073
MQPSRNFDDL
KF
S
SI
H
R
RI
LLWG
SG
GP
F
LDGYVL
VM
IGVAL
E
QLTPA
LK
L
DA
D
WI
G
LL
G
AGT
L
A
GLFVG
TS
LF
GYISD
KV
GRRK
M
F
L
ID
I
I
A
IGV
I
S
VATM
FV
SS
P
VE
L
L
VM
R
V
LIGI
V
IGADY
P
IA
T
S
MI
TEFS
S
T
R
Q
R
A
FSISFIA
--------
AM
W
Y
VG
ATC
A
D
L
VG
-
YWLYDVEGG
WRWML
G
SAAIP
C
LLI
LIG
R
F
EL
--------------------
PESPRWLLRKGR
V
K
E
C
E
EM
M
I
K
L
FG
EP
V
AFEE
EQ
PQQ
T
-
-
R
F
R
-----
--
--------------
D
LF
NR
R
HF
PFV
LF
VAAIWT
C
Q
--
VIP
M
F
A
IYT
F
G
P
Q
I
VGLL
GL
G
V
G
K
N
A
ALG
N
VVIS
L
FF
MLG
C
-----
I
PP
M
L
WL
N
TAG
RR
PL
L
I
GS
F
AM
M
TLA
LAVLG
L
IP
D
M
G
IW
--------
LVVM
A
F
A
-
VY
AF
F
S
GG
PG
NL
QW
LYP
N
ELFPTDIR
AS
A
VG
V
IM
S
LSRIG
T
I
VST
WA
LP
I
------
F
I
N
N
YG
-
I
S
N
TML
M
GA
G
I
S
L
F
GL
L
IS
VA
FAPETR
G
MSL
AQT
SN
M
TIRGQRMG
fig|199310.4.peg.52
Escherichia coli CFT073
MQPSRNFDDL
KF
S
SI
H
R
RI
LLWG
SG
GP
F
LDGYVL
VM
IGVAL
E
QLTPA
LK
L
DA
D
WI
G
LL
G
AGT
L
A
GLFVG
TS
LF
GYISD
KV
GRRK
M
F
L
ID
I
I
A
IGV
I
S
VATM
FV
SS
P
VE
L
L
VM
R
V
LIGI
V
IGADY
P
IA
T
S
MI
TEFS
S
T
R
Q
R
A
FSISFIA
--------
AM
W
Y
VG
ATC
A
D
L
VG
-
YWLYDVEGG
WRWML
G
SAAIP
C
LLI
LIG
R
F
EL
--------------------
PESPRWLLRKGR
V
K
E
C
E
EM
M
I
K
L
FG
EP
V
AFEE
EQ
PQQ
T
-
-
R
F
R
-----
--
--------------
D
LF
NR
R
HF
PFV
LF
VAAIWT
C
Q
--
VIP
M
F
A
IYT
F
G
P
Q
I
VGLL
GL
G
V
G
K
N
A
ALG
N
VVIS
L
FF
MLG
C
-----
I
PP
M
L
WL
N
TAG
RR
PL
L
I
GS
F
AM
M
TLA
LAVLG
L
IP
D
M
G
IW
--------
LVVM
A
F
A
-
VY
AF
F
S
GG
PG
NL
QW
LYP
N
ELFPTDIR
AS
A
VG
V
IM
S
LSRIG
T
I
VST
WA
LP
I
------
F
I
N
N
YG
-
I
S
N
TML
M
GA
G
I
S
L
F
GL
L
IS
VA
FAPETR
G
MSL
AQT
SN
M
TIRGQRMG
fig|585397.7.peg.47
Escherichia coli ED1a
MQPSRNFDDL
KF
S
SI
H
R
RI
LLWG
SG
GP
F
LDGYVL
VM
IGVAL
E
QLTPA
LK
L
DA
D
WI
G
LL
G
AGT
L
A
GLFVG
TS
LF
GYISD
KV
GRRK
M
F
L
ID
I
I
A
IGV
I
S
VATM
FV
SS
P
VE
L
L
VM
R
V
LIGI
V
IGADY
P
IA
T
S
MI
TEFS
S
T
R
Q
R
A
FSISFIA
--------
AM
W
Y
VG
ATC
A
D
L
VG
-
YWLYDVEGG
WRWML
G
SAAIP
C
LLI
LIG
R
F
EL
--------------------
PESPRWLLRKGR
V
K
E
C
E
EM
M
I
K
L
FG
EP
V
AFEE
EQ
PQQ
T
-
-
R
F
R
-----
--
--------------
D
LF
NR
R
HF
PFV
LF
VAAIWT
C
Q
--
VIP
M
F
A
IYT
F
G
P
Q
I
VGLL
GL
G
V
G
K
N
A
ALG
N
VVIS
L
FF
MLG
C
-----
I
PP
M
L
WL
N
TAG
RR
PL
L
I
GS
F
AM
M
TLA
LAVLG
L
IP
D
M
G
IW
--------
LVVM
A
F
A
-
VY
AF
F
S
GG
PG
NL
QW
LYP
N
ELFPTDIR
AS
A
VG
V
IM
S
LSRIG
T
I
VST
WA
LP
I
------
F
I
N
N
YG
-
I
S
N
TML
M
GA
G
I
S
L
F
GL
L
IS
VA
FAPETR
G
MSL
AQT
SN
M
TIRGQRMG
fig|585397.9.peg.47
Escherichia coli ED1a
MQPSRNFDDL
KF
S
SI
H
R
RI
LLWG
SG
GP
F
LDGYVL
VM
IGVAL
E
QLTPA
LK
L
DA
D
WI
G
LL
G
AGT
L
A
GLFVG
TS
LF
GYISD
KV
GRRK
M
F
L
ID
I
I
A
IGV
I
S
VATM
FV
SS
P
VE
L
L
VM
R
V
LIGI
V
IGADY
P
IA
T
S
MI
TEFS
S
T
R
Q
R
A
FSISFIA
--------
AM
W
Y
VG
ATC
A
D
L
VG
-
YWLYDVEGG
WRWML
G
SAAIP
C
LLI
LIG
R
F
EL
--------------------
PESPRWLLRKGR
V
K
E
C
E
EM
M
I
K
L
FG
EP
V
AFEE
EQ
PQQ
T
-
-
R
F
R
-----
--
--------------
D
LF
NR
R
HF
PFV
LF
VAAIWT
C
Q
--
VIP
M
F
A
IYT
F
G
P
Q
I
VGLL
GL
G
V
G
K
N
A
ALG
N
VVIS
L
FF
MLG
C
-----
I
PP
M
L
WL
N
TAG
RR
PL
L
I
GS
F
AM
M
TLA
LAVLG
L
IP
D
M
G
IW
--------
LVVM
A
F
A
-
VY
AF
F
S
GG
PG
NL
QW
LYP
N
ELFPTDIR
AS
A
VG
V
IM
S
LSRIG
T
I
VST
WA
LP
I
------
F
I
N
N
YG
-
I
S
N
TML
M
GA
G
I
S
L
F
GL
L
IS
VA
FAPETR
G
MSL
AQT
SN
M
TIRGQRMG
fig|714962.3.peg.48
Escherichia coli IHE3034
MQPSRNFDDL
KF
S
SI
H
R
RI
LLWG
SG
GP
F
LDGYVL
VM
IGVAL
E
QLTPA
LK
L
DA
D
WI
G
LL
G
AGT
L
A
GLFVG
TS
LF
GYISD
KV
GRRK
M
F
L
ID
I
I
A
IGV
I
S
VATM
FV
SS
P
VE
L
L
VM
R
V
LIGI
V
IGADY
P
IA
T
S
MI
TEFS
S
T
R
Q
R
A
FSISFIA
--------
AM
W
Y
VG
ATC
A
D
L
VG
-
YWLYDVEGG
WRWML
G
SAAIP
C
LLI
LIG
R
F
EL
--------------------
PESPRWLLRKGR
V
K
E
C
E
EM
M
I
K
L
FG
EP
V
AFEE
EQ
PQQ
T
-
-
R
F
R
-----
--
--------------
D
LF
NR
R
HF
PFV
LF
VAAIWT
C
Q
--
VIP
M
F
A
IYT
F
G
P
Q
I
VGLL
GL
G
V
G
K
N
A
ALG
N
VVIS
L
FF
MLG
C
-----
I
PP
M
L
WL
N
TAG
RR
PL
L
I
GS
F
AM
M
TLA
LAVLG
L
IP
D
M
G
IW
--------
LVVM
A
F
A
-
VY
AF
F
S
GG
PG
NL
QW
LYP
N
ELFPTDIR
AS
A
VG
V
IM
S
LSRIG
T
I
VST
WA
LP
I
------
F
I
N
N
YG
-
I
S
N
TML
M
GA
G
I
S
L
F
GL
L
IS
VA
FAPETR
G
MSL
AQT
SN
M
TIRGQRMG
fig|749546.3.peg.2348
Escherichia coli MS 185-1
MQPSRNFDDL
KF
S
SI
H
R
RI
LLWG
SG
GP
F
LDGYVL
VM
IGVAL
E
QLTPA
LK
L
DA
D
WI
G
LL
G
AGT
L
A
GLFVG
TS
LF
GYISD
KV
GRRK
M
F
L
ID
I
I
A
IGV
I
S
VATM
FV
SS
P
VE
L
L
VM
R
V
LIGI
V
IGADY
P
IA
T
S
MI
TEFS
S
T
R
Q
R
A
FSISFIA
--------
AM
W
Y
VG
ATC
A
D
L
VG
-
YWLYDVEGG
WRWML
G
SAAIP
C
LLI
LIG
R
F
EL
--------------------
PESPRWLLRKGR
V
K
E
C
E
EM
M
I
K
L
FG
EP
V
AFEE
EQ
PQQ
T
-
-
R
F
R
-----
--
--------------
D
LF
NR
R
HF
PFV
LF
VAAIWT
C
Q
--
VIP
M
F
A
IYT
F
G
P
Q
I
VGLL
GL
G
V
G
K
N
A
ALG
N
VVIS
L
FF
MLG
C
-----
I
PP
M
L
WL
N
TAG
RR
PL
L
I
GS
F
AM
M
TLA
LAVLG
L
IP
D
M
G
IW
--------
LVVM
A
F
A
-
VY
AF
F
S
GG
PG
NL
QW
LYP
N
ELFPTDIR
AS
A
VG
V
IM
S
LSRIG
T
I
VST
WA
LP
I
------
F
I
N
N
YG
-
I
S
N
TML
M
GA
G
I
S
L
F
GL
L
IS
VA
FAPETR
G
MSL
AQT
SN
M
TIRGQRMG
fig|749528.3.peg.2192
Escherichia coli MS 45-1
MQPSRNFDDL
KF
S
SI
H
R
RI
LLWG
SG
GP
F
LDGYVL
VM
IGVAL
E
QLTPA
LK
L
DA
D
WI
G
LL
G
AGT
L
A
GLFVG
TS
LF
GYISD
KV
GRRK
M
F
L
ID
I
I
A
IGV
I
S
VATM
FV
SS
P
VE
L
L
VM
R
V
LIGI
V
IGADY
P
IA
T
S
MI
TEFS
S
T
R
Q
R
A
FSISFIA
--------
AM
W
Y
VG
ATC
A
D
L
VG
-
YWLYDVEGG
WRWML
G
SAAIP
C
LLI
LIG
R
F
EL
--------------------
PESPRWLLRKGR
V
K
E
C
E
EM
M
I
K
L
FG
EP
V
AFEE
EQ
PQQ
T
-
-
R
F
R
-----
--
--------------
D
LF
NR
R
HF
PFV
LF
VAAIWT
C
Q
--
VIP
M
F
A
IYT
F
G
P
Q
I
VGLL
GL
G
V
G
K
N
A
ALG
N
VVIS
L
FF
MLG
C
-----
I
PP
M
L
WL
N
TAG
RR
PL
L
I
GS
F
AM
M
TLA
LAVLG
L
IP
D
M
G
IW
--------
LVVM
A
F
A
-
VY
AF
F
S
GG
PG
NL
QW
LYP
N
ELFPTDIR
AS
A
VG
V
IM
S
LSRIG
T
I
VST
WA
LP
I
------
F
I
N
N
YG
-
I
S
N
TML
M
GA
G
I
S
L
F
GL
L
IS
VA
FAPETR
G
MSL
AQT
SN
M
TIRGQRMG
fig|753642.3.peg.3592
Escherichia coli NC101
MQPSRNFDDL
KF
S
SI
H
R
RI
LLWG
SG
GP
F
LDGYVL
VM
IGVAL
E
QLTPA
LK
L
DA
D
WI
G
LL
G
AGT
L
A
GLFVG
TS
LF
GYISD
KV
GRRK
M
F
L
ID
I
I
A
IGV
I
S
VATM
FV
SS
P
VE
L
L
VM
R
V
LIGI
V
IGADY
P
IA
T
S
MI
TEFS
S
T
R
Q
R
A
FSISFIA
--------
AM
W
Y
VG
ATC
A
D
L
VG
-
YWLYDVEGG
WRWML
G
SAAIP
C
LLI
LIG
R
F
EL
--------------------
PESPRWLLRKGR
V
K
E
C
E
EM
M
I
K
L
FG
EP
V
AFEE
EQ
PQQ
T
-
-
R
F
R
-----
--
--------------
D
LF
NR
R
HF
PFV
LF
VAAIWT
C
Q
--
VIP
M
F
A
IYT
F
G
P
Q
I
VGLL
GL
G
V
G
K
N
A
ALG
N
VVIS
L
FF
MLG
C
-----
I
PP
M
L
WL
N
TAG
RR
PL
L
I
GS
F
AM
M
TLA
LAVLG
L
IP
D
M
G
IW
--------
LVVM
A
F
A
-
VY
AF
F
S
GG
PG
NL
QW
LYP
N
ELFPTDIR
AS
A
VG
V
IM
S
LSRIG
T
I
VST
WA
LP
I
------
F
I
N
N
YG
-
I
S
N
TML
M
GA
G
I
S
L
F
GL
L
IS
VA
FAPETR
G
MSL
AQT
SN
M
TIRGQRMG
fig|685038.3.peg.45
Escherichia coli O83:H1 str. NRG 857C
MQPSRNFDDL
KF
S
SI
H
R
RI
LLWG
SG
GP
F
LDGYVL
VM
IGVAL
E
QLTPA
LK
L
DA
D
WI
G
LL
G
AGT
L
A
GLFVG
TS
LF
GYISD
KV
GRRK
M
F
L
ID
I
I
A
IGV
I
S
VATM
FV
SS
P
VE
L
L
VM
R
V
LIGI
V
IGADY
P
IA
T
S
MI
TEFS
S
T
R
Q
R
A
FSISFIA
--------
AM
W
Y
VG
ATC
A
D
L
VG
-
YWLYDVEGG
WRWML
G
SAAIP
C
LLI
LIG
R
F
EL
--------------------
PESPRWLLRKGR
V
K
E
C
E
EM
M
I
K
L
FG
EP
V
AFEE
EQ
PQQ
T
-
-
R
F
R
-----
--
--------------
D
LF
NR
R
HF
PFV
LF
VAAIWT
C
Q
--
VIP
M
F
A
IYT
F
G
P
Q
I
VGLL
GL
G
V
G
K
N
A
ALG
N
VVIS
L
FF
MLG
C
-----
I
PP
M
L
WL
N
TAG
RR
PL
L
I
GS
F
AM
M
TLA
LAVLG
L
IP
D
M
G
IW
--------
LVVM
A
F
A
-
VY
AF
F
S
GG
PG
NL
QW
LYP
N
ELFPTDIR
AS
A
VG
V
IM
S
LSRIG
T
I
VST
WA
LP
I
------
F
I
N
N
YG
-
I
S
N
TML
M
GA
G
I
S
L
F
GL
L
IS
VA
FAPETR
G
MSL
AQT
SN
M
TIRGQRMG
fig|585035.6.peg.50
Escherichia coli S88
MQPSRNFDDL
KF
S
SI
H
R
RI
LLWG
SG
GP
F
LDGYVL
VM
IGVAL
E
QLTPA
LK
L
DA
D
WI
G
LL
G
AGT
L
A
GLFVG
TS
LF
GYISD
KV
GRRK
M
F
L
ID
I
I
A
IGV
I
S
VATM
FV
SS
P
VE
L
L
VM
R
V
LIGI
V
IGADY
P
IA
T
S
MI
TEFS
S
T
R
Q
R
A
FSISFIA
--------
AM
W
Y
VG
ATC
A
D
L
VG
-
YWLYDVEGG
WRWML
G
SAAIP
C
LLI
LIG
R
F
EL
--------------------
PESPRWLLRKGR
V
K
E
C
E
EM
M
I
K
L
FG
EP
V
AFEE
EQ
PQQ
T
-
-
R
F
R
-----
--
--------------
D
LF
NR
R
HF
PFV
LF
VAAIWT
C
Q
--
VIP
M
F
A
IYT
F
G
P
Q
I
VGLL
GL
G
V
G
K
N
A
ALG
N
VVIS
L
FF
MLG
C
-----
I
PP
M
L
WL
N
TAG
RR
PL
L
I
GS
F
AM
M
TLA
LAVLG
L
IP
D
M
G
IW
--------
LVVM
A
F
A
-
VY
AF
F
S
GG
PG
NL
QW
LYP
N
ELFPTDIR
AS
A
VG
V
IM
S
LSRIG
T
I
VST
WA
LP
I
------
F
I
N
N
YG
-
I
S
N
TML
M
GA
G
I
S
L
F
GL
L
IS
VA
FAPETR
G
MSL
AQT
SN
M
TIRGQRMG
fig|431946.3.peg.48
Escherichia coli SE15
MQPSRNFDDL
KF
S
SI
H
R
RI
LLWG
SG
GP
F
LDGYVL
VM
IGVAL
E
QLTPA
LK
L
DA
D
WI
G
LL
G
AGT
L
A
GLFVG
TS
LF
GYISD
KV
GRRK
M
F
L
ID
I
I
A
IGV
I
S
VATM
FV
SS
P
VE
L
L
VM
R
V
LIGI
V
IGADY
P
IA
T
S
MI
TEFS
S
T
R
Q
R
A
FSISFIA
--------
AM
W
Y
VG
ATC
A
D
L
VG
-
YWLYDVEGG
WRWML
G
SAAIP
C
LLI
LIG
R
F
EL
--------------------
PESPRWLLRKGR
V
K
E
C
E
EM
M
I
K
L
FG
EP
V
AFEE
EQ
PQQ
T
-
-
R
F
R
-----
--
--------------
D
LF
NR
R
HF
PFV
LF
VAAIWT
C
Q
--
VIP
M
F
A
IYT
F
G
P
Q
I
VGLL
GL
G
V
G
K
N
A
ALG
N
VVIS
L
FF
MLG
C
-----
I
PP
M
L
WL
N
TAG
RR
PL
L
I
GS
F
AM
M
TLA
LAVLG
L
IP
D
M
G
IW
--------
LVVM
A
F
A
-
VY
AF
F
S
GG
PG
NL
QW
LYP
N
ELFPTDIR
AS
A
VG
V
IM
S
LSRIG
T
I
VST
WA
LP
I
------
F
I
N
N
YG
-
I
S
N
TML
M
GA
G
I
S
L
F
GL
L
IS
VA
FAPETR
G
MSL
AQT
SN
M
TIRGQRMG
fig|656440.3.peg.5100
Escherichia coli TA206
MQPSRNFDDL
KF
S
SI
H
R
RI
LLWG
SG
GP
F
LDGYVL
VM
IGVAL
E
QLTPA
LK
L
DA
D
WI
G
LL
G
AGT
L
A
GLFVG
TS
LF
GYISD
KV
GRRK
M
F
L
ID
I
I
A
IGV
I
S
VATM
FV
SS
P
VE
L
L
VM
R
V
LIGI
V
IGADY
P
IA
T
S
MI
TEFS
S
T
R
Q
R
A
FSISFIA
--------
AM
W
Y
VG
ATC
A
D
L
VG
-
YWLYDVEGG
WRWML
G
SAAIP
C
LLI
LIG
R
F
EL
--------------------
PESPRWLLRKGR
V
K
E
C
E
EM
M
I
K
L
FG
EP
V
AFEE
EQ
PQQ
T
-
-
R
F
R
-----
--
--------------
D
LF
NR
R
HF
PFV
LF
VAAIWT
C
Q
--
VIP
M
F
A
IYT
F
G
P
Q
I
VGLL
GL
G
V
G
K
N
A
ALG
N
VVIS
L
FF
MLG
C
-----
I
PP
M
L
WL
N
TAG
RR
PL
L
I
GS
F
AM
M
TLA
LAVLG
L
IP
D
M
G
IW
--------
LVVM
A
F
A
-
VY
AF
F
S
GG
PG
NL
QW
LYP
N
ELFPTDIR
AS
A
VG
V
IM
S
LSRIG
T
I
VST
WA
LP
I
------
F
I
N
N
YG
-
I
S
N
TML
M
GA
G
I
S
L
F
GL
L
IS
VA
FAPETR
G
MSL
AQT
SN
M
TIRGQRMG
fig|869729.3.peg.4948
Escherichia coli UM146
MQPSRNFDDL
KF
S
SI
H
R
RI
LLWG
SG
GP
F
LDGYVL
VM
IGVAL
E
QLTPA
LK
L
DA
D
WI
G
LL
G
AGT
L
A
GLFVG
TS
LF
GYISD
KV
GRRK
M
F
L
ID
I
I
A
IGV
I
S
VATM
FV
SS
P
VE
L
L
VM
R
V
LIGI
V
IGADY
P
IA
T
S
MI
TEFS
S
T
R
Q
R
A
FSISFIA
--------
AM
W
Y
VG
ATC
A
D
L
VG
-
YWLYDVEGG
WRWML
G
SAAIP
C
LLI
LIG
R
F
EL
--------------------
PESPRWLLRKGR
V
K
E
C
E
EM
M
I
K
L
FG
EP
V
AFEE
EQ
PQQ
T
-
-
R
F
R
-----
--
--------------
D
LF
NR
R
HF
PFV
LF
VAAIWT
C
Q
--
VIP
M
F
A
IYT
F
G
P
Q
I
VGLL
GL
G
V
G
K
N
A
ALG
N
VVIS
L
FF
MLG
C
-----
I
PP
M
L
WL
N
TAG
RR
PL
L
I
GS
F
AM
M
TLA
LAVLG
L
IP
D
M
G
IW
--------
LVVM
A
F
A
-
VY
AF
F
S
GG
PG
NL
QW
LYP
N
ELFPTDIR
AS
A
VG
V
IM
S
LSRIG
T
I
VST
WA
LP
I
------
F
I
N
N
YG
-
I
S
N
TML
M
GA
G
I
S
L
F
GL
L
IS
VA
FAPETR
G
MSL
AQT
SN
M
TIRGQRMG
fig|364106.7.peg.182
Escherichia coli UTI89
MQPSRNFDDL
KF
S
SI
H
R
RI
LLWG
SG
GP
F
LDGYVL
VM
IGVAL
E
QLTPA
LK
L
DA
D
WI
G
LL
G
AGT
L
A
GLFVG
TS
LF
GYISD
KV
GRRK
M
F
L
ID
I
I
A
IGV
I
S
VATM
FV
SS
P
VE
L
L
VM
R
V
LIGI
V
IGADY
P
IA
T
S
MI
TEFS
S
T
R
Q
R
A
FSISFIA
--------
AM
W
Y
VG
ATC
A
D
L
VG
-
YWLYDVEGG
WRWML
G
SAAIP
C
LLI
LIG
R
F
EL
--------------------
PESPRWLLRKGR
V
K
E
C
E
EM
M
I
K
L
FG
EP
V
AFEE
EQ
PQQ
T
-
-
R
F
R
-----
--
--------------
D
LF
NR
R
HF
PFV
LF
VAAIWT
C
Q
--
VIP
M
F
A
IYT
F
G
P
Q
I
VGLL
GL
G
V
G
K
N
A
ALG
N
VVIS
L
FF
MLG
C
-----
I
PP
M
L
WL
N
TAG
RR
PL
L
I
GS
F
AM
M
TLA
LAVLG
L
IP
D
M
G
IW
--------
LVVM
A
F
A
-
VY
AF
F
S
GG
PG
NL
QW
LYP
N
ELFPTDIR
AS
A
VG
V
IM
S
LSRIG
T
I
VST
WA
LP
I
------
F
I
N
N
YG
-
I
S
N
TML
M
GA
G
I
S
L
F
GL
L
IS
VA
FAPETR
G
MSL
AQT
SN
M
TIRGQRMG
fig|364106.8.peg.181
Escherichia coli UTI89
MQPSRNFDDL
KF
S
SI
H
R
RI
LLWG
SG
GP
F
LDGYVL
VM
IGVAL
E
QLTPA
LK
L
DA
D
WI
G
LL
G
AGT
L
A
GLFVG
TS
LF
GYISD
KV
GRRK
M
F
L
ID
I
I
A
IGV
I
S
VATM
FV
SS
P
VE
L
L
VM
R
V
LIGI
V
IGADY
P
IA
T
S
MI
TEFS
S
T
R
Q
R
A
FSISFIA
--------
AM
W
Y
VG
ATC
A
D
L
VG
-
YWLYDVEGG
WRWML
G
SAAIP
C
LLI
LIG
R
F
EL
--------------------
PESPRWLLRKGR
V
K
E
C
E
EM
M
I
K
L
FG
EP
V
AFEE
EQ
PQQ
T
-
-
R
F
R
-----
--
--------------
D
LF
NR
R
HF
PFV
LF
VAAIWT
C
Q
--
VIP
M
F
A
IYT
F
G
P
Q
I
VGLL
GL
G
V
G
K
N
A
ALG
N
VVIS
L
FF
MLG
C
-----
I
PP
M
L
WL
N
TAG
RR
PL
L
I
GS
F
AM
M
TLA
LAVLG
L
IP
D
M
G
IW
--------
LVVM
A
F
A
-
VY
AF
F
S
GG
PG
NL
QW
LYP
N
ELFPTDIR
AS
A
VG
V
IM
S
LSRIG
T
I
VST
WA
LP
I
------
F
I
N
N
YG
-
I
S
N
TML
M
GA
G
I
S
L
F
GL
L
IS
VA
FAPETR
G
MSL
AQT
SN
M
TIRGQRMG
fig|562.376.peg.1272
Escherichia coli WV_060327
MQPSRNFDDL
KF
S
SI
H
R
RI
LLWG
SG
GP
F
LDGYVL
VM
IGVAL
E
QLTPA
LK
L
DA
D
WI
G
LL
G
AGT
L
A
GLFVG
TS
LF
GYISD
KV
GRRK
M
F
L
ID
I
I
A
IGV
I
S
VATM
FV
SS
P
VE
L
L
VM
R
V
LIGI
V
IGADY
P
IA
T
S
MI
TEFS
S
T
R
Q
R
A
FSISFIA
--------
AM
W
Y
VG
ATC
A
D
L
VG
-
YWLYDVEGG
WRWML
G
SAAIP
C
LLI
LIG
R
F
EL
--------------------
PESPRWLLRKGR
V
K
E
C
E
EM
M
I
K
L
FG
EP
V
AFEE
EQ
PQQ
T
-
-
R
F
R
-----
--
--------------
D
LF
NR
R
HF
PFV
LF
VAAIWT
C
Q
--
VIP
M
F
A
IYT
F
G
P
Q
I
VGLL
GL
G
V
G
K
N
A
ALG
N
VVIS
L
FF
MLG
C
-----
I
PP
M
L
WL
N
TAG
RR
PL
L
I
GS
F
AM
M
TLA
LAVLG
L
IP
D
M
G
IW
--------
LVVM
A
F
A
-
VY
AF
F
S
GG
PG
NL
QW
LYP
N
ELFPTDIR
AS
A
VG
V
IM
S
LSRIG
T
I
VST
WA
LP
I
------
F
I
N
N
YG
-
I
S
N
TML
M
GA
G
I
S
L
F
GL
L
IS
VA
FAPETR
G
MSL
AQT
SN
M
TIRGQRMG
fig|585057.4.peg.50
Escherichia coli IAI39
MQPSRNFDDL
KF
S
SI
H
R
RI
LLWG
SG
GP
F
LDGYVL
VM
IGVAL
E
QLTPA
LK
L
DA
D
WI
G
LL
G
AGT
L
A
GLFVG
TS
LF
GYISD
KV
GRRK
M
F
L
ID
I
I
A
IGV
I
S
VATM
FV
SS
P
VE
L
L
VM
R
V
LIGI
V
IGADY
P
IA
T
S
MI
TEFS
S
T
R
Q
R
A
FSISFIA
--------
AM
W
Y
VG
ATC
A
D
L
VG
-
YWLYDVEGG
WRWML
G
SAAIP
C
LLI
LIG
R
F
EL
--------------------
PESPRWLLRKGR
V
K
E
C
E
EM
M
I
K
L
FG
EP
V
AFDE
EQ
PQQ
T
-
-
R
F
R
-----
--
--------------
D
LF
NR
R
HF
PFV
LF
VAAIWT
C
Q
--
VIP
M
F
A
IYT
F
G
P
Q
I
VGLL
GL
G
V
G
K
N
A
ALG
N
VVIS
L
FF
MLG
C
-----
I
PP
M
L
WL
N
TAG
RR
PL
L
I
GS
F
AM
M
TLA
LAVLG
L
IP
D
M
G
IW
--------
LVVM
A
F
A
-
VY
AF
F
S
GG
PG
NL
QW
LYP
N
ELFPTDIR
AS
A
VG
V
IM
S
LSRIG
T
I
VST
WA
LP
I
------
F
I
N
N
YG
-
I
S
S
TML
M
GA
G
I
S
L
F
GL
L
IS
VA
FAPETR
G
MSL
AQT
SN
M
TIRGQRMG
fig|585057.6.peg.50
Escherichia coli IAI39
MQPSRNFDDL
KF
S
SI
H
R
RI
LLWG
SG
GP
F
LDGYVL
VM
IGVAL
E
QLTPA
LK
L
DA
D
WI
G
LL
G
AGT
L
A
GLFVG
TS
LF
GYISD
KV
GRRK
M
F
L
ID
I
I
A
IGV
I
S
VATM
FV
SS
P
VE
L
L
VM
R
V
LIGI
V
IGADY
P
IA
T
S
MI
TEFS
S
T
R
Q
R
A
FSISFIA
--------
AM
W
Y
VG
ATC
A
D
L
VG
-
YWLYDVEGG
WRWML
G
SAAIP
C
LLI
LIG
R
F
EL
--------------------
PESPRWLLRKGR
V
K
E
C
E
EM
M
I
K
L
FG
EP
V
AFDE
EQ
PQQ
T
-
-
R
F
R
-----
--
--------------
D
LF
NR
R
HF
PFV
LF
VAAIWT
C
Q
--
VIP
M
F
A
IYT
F
G
P
Q
I
VGLL
GL
G
V
G
K
N
A
ALG
N
VVIS
L
FF
MLG
C
-----
I
PP
M
L
WL
N
TAG
RR
PL
L
I
GS
F
AM
M
TLA
LAVLG
L
IP
D
M
G
IW
--------
LVVM
A
F
A
-
VY
AF
F
S
GG
PG
NL
QW
LYP
N
ELFPTDIR
AS
A
VG
V
IM
S
LSRIG
T
I
VST
WA
LP
I
------
F
I
N
N
YG
-
I
S
S
TML
M
GA
G
I
S
L
F
GL
L
IS
VA
FAPETR
G
MSL
AQT
SN
M
TIRGQRMG
fig|749527.3.peg.4042
Escherichia coli MS 21-1
MQPSRNFDDL
KF
S
SI
H
R
RI
LLWG
SG
GP
F
LDGYVL
VM
IGVAL
E
QLTPA
LK
L
DA
D
WI
G
LL
G
AGT
L
A
GLFVG
TS
LF
GYISD
KV
GRRK
M
F
L
ID
I
I
A
IGV
I
S
VATM
FV
SS
P
VE
L
L
VM
R
V
LIGI
V
IGADY
P
IA
T
S
MI
TEFS
S
T
R
Q
R
A
FSISFIA
--------
AM
W
Y
VG
ATC
A
D
L
VG
-
YWLYDVEGG
WRWML
G
SAAIP
C
LLI
LIG
R
F
EL
--------------------
PESPRWLLRKGR
V
K
E
C
E
EM
M
I
K
L
FG
EP
V
AFDE
EQ
PQQ
T
-
-
R
F
R
-----
--
--------------
D
LF
NR
R
HF
PFV
LF
VAAIWT
C
Q
--
VIP
M
F
A
IYT
F
G
P
Q
I
VGLL
GL
G
V
G
K
N
A
ALG
N
VVIS
L
FF
MLG
C
-----
I
PP
M
L
WL
N
TAG
RR
PL
L
I
GS
F
AM
M
TLA
LAVLG
L
IP
D
M
G
IW
--------
LVVM
A
F
A
-
VY
AF
F
S
GG
PG
NL
QW
LYP
N
ELFPTDIR
AS
A
VG
V
IM
S
LSRIG
T
I
VST
WA
LP
I
------
F
I
N
N
YG
-
I
S
S
TML
M
GA
G
I
S
L
F
GL
L
IS
VA
FAPETR
G
MSL
AQT
SN
M
TIRGQRMG
fig|439855.10.peg.222
Escherichia coli SMS-3-5
MQPSRNFDDL
KF
S
SI
H
R
RI
LLWG
SG
GP
F
LDGYVL
VM
IGVAL
E
QLTPA
LK
L
DA
D
WI
G
LL
G
AGT
L
A
GLFVG
TS
LF
GYISD
KV
GRRK
M
F
L
ID
I
I
A
IGV
I
S
VATM
FV
SS
P
VE
L
L
VM
R
V
LIGI
V
IGADY
P
IA
T
S
MI
TEFS
S
T
R
Q
R
A
FSISFIA
--------
AM
W
Y
VG
ATC
A
D
L
VG
-
YWLYDVEGG
WRWML
G
SAAIP
C
LLI
LIG
R
F
EL
--------------------
PESPRWLLRKGR
V
K
E
C
E
EM
M
I
K
L
FG
EP
V
AFDE
EQ
PQQ
T
-
-
R
F
R
-----
--
--------------
D
LF
NR
R
HF
PFV
LF
VAAIWT
C
Q
--
VIP
M
F
A
IYT
F
G
P
Q
I
VGLL
GL
G
V
G
K
N
A
ALG
N
VVIS
L
FF
MLG
C
-----
I
PP
M
L
WL
N
TAG
RR
PL
L
I
GS
F
AM
M
TLA
LAVLG
L
IP
D
M
G
IW
--------
LVVM
A
F
A
-
VY
AF
F
S
GG
PG
NL
QW
LYP
N
ELFPTDIR
AS
A
VG
V
IM
S
LSRIG
T
I
VST
WA
LP
I
------
F
I
N
N
YG
-
I
S
S
TML
M
GA
G
I
S
L
F
GL
L
IS
VA
FAPETR
G
MSL
AQT
SN
M
TIRGQRMG
fig|331111.12.peg.378
Escherichia coli E24377A
MQPSRNFDDL
KF
S
SI
H
R
RI
LLWG
SG
GP
F
LDGYVL
VM
IGVAL
E
QLTPA
LK
L
DA
D
WI
G
LL
G
AGT
L
A
GLFVG
TS
LF
GYISD
KV
GRRK
M
F
L
ID
I
I
A
IGV
I
S
VATM
FV
SS
P
VE
L
L
VM
R
V
LIGI
V
IGADY
P
IA
T
S
MI
TEFS
S
T
R
Q
R
A
FSISFIA
--------
AM
W
Y
VG
ATC
A
D
L
VG
-
YWLYDMEGG
WRWML
G
SAAIP
C
LLI
LIG
R
F
EL
--------------------
PESPRWLLRKGR
V
K
E
C
E
EM
M
I
K
L
FG
EP
V
AFDE
EQ
PQQ
T
-
-
R
F
R
-----
--
--------------
D
LF
NR
R
HF
PFV
LF
VAAIWT
C
Q
--
VIP
M
F
A
IYT
F
G
P
Q
I
VGLL
GL
G
V
G
K
N
A
ALG
N
VVIS
L
FF
MLG
C
-----
I
PP
M
L
WL
N
TAG
RR
PL
L
I
GS
F
AM
M
TLA
LAVLG
L
IP
D
M
G
IW
--------
LVVM
A
F
A
-
VY
AF
F
S
GG
PG
NL
QW
LYP
N
ELFPTDIR
AS
A
VG
V
IM
S
LSRIG
T
I
VST
WA
LP
I
------
F
I
N
N
YG
-
I
S
N
TML
M
GA
G
I
S
L
F
GL
L
IS
VV
FAPETR
G
MSL
AQT
SN
M
TIRGQRMG
fig|331111.3.peg.2619
Escherichia coli E24377A
MQPSRNFDDL
KF
S
SI
H
R
RI
LLWG
SG
GP
F
LDGYVL
VM
IGVAL
E
QLTPA
LK
L
DA
D
WI
G
LL
G
AGT
L
A
GLFVG
TS
LF
GYISD
KV
GRRK
M
F
L
ID
I
I
A
IGV
I
S
VATM
FV
SS
P
VE
L
L
VM
R
V
LIGI
V
IGADY
P
IA
T
S
MI
TEFS
S
T
R
Q
R
A
FSISFIA
--------
AM
W
Y
VG
ATC
A
D
L
VG
-
YWLYDMEGG
WRWML
G
SAAIP
C
LLI
LIG
R
F
EL
--------------------
PESPRWLLRKGR
V
K
E
C
E
EM
M
I
K
L
FG
EP
V
AFDE
EQ
PQQ
T
-
-
R
F
R
-----
--
--------------
D
LF
NR
R
HF
PFV
LF
VAAIWT
C
Q
--
VIP
M
F
A
IYT
F
G
P
Q
I
VGLL
GL
G
V
G
K
N
A
ALG
N
VVIS
L
FF
MLG
C
-----
I
PP
M
L
WL
N
TAG
RR
PL
L
I
GS
F
AM
M
TLA
LAVLG
L
IP
D
M
G
IW
--------
LVVM
A
F
A
-
VY
AF
F
S
GG
PG
NL
QW
LYP
N
ELFPTDIR
AS
A
VG
V
IM
S
LSRIG
T
I
VST
WA
LP
I
------
F
I
N
N
YG
-
I
S
N
TML
M
GA
G
I
S
L
F
GL
L
IS
VV
FAPETR
G
MSL
AQT
SN
M
TIRGQRMG
fig|656417.3.peg.107
Escherichia coli M605
MQPSRNFDDL
KF
S
SI
H
R
RI
LLWG
SG
GP
F
LDGYVL
VM
IGVAL
E
QLTPA
LK
L
DA
D
WI
G
LL
G
AGT
L
A
GLFVG
TS
LF
GYISD
KV
GRRK
M
F
L
ID
I
I
A
IGV
I
S
VATM
FV
SS
P
VE
L
L
VM
R
V
LIGI
V
IGADY
P
IA
T
S
MI
TEFS
S
T
R
Q
R
A
FSISFIA
--------
AM
W
Y
VG
ATC
A
D
L
VG
-
YWLYDVEGG
WRWML
G
SAAIP
C
LLI
LIG
R
F
EL
--------------------
PESPRWLLRKGR
V
K
E
C
E
EM
M
I
K
L
FG
EP
V
AFEE
EQ
LQQ
T
-
-
R
F
R
-----
--
--------------
D
LF
NR
R
HF
PFV
LF
VAAIWT
C
Q
--
VIP
M
F
A
IYT
F
G
P
Q
I
VGLL
GL
G
V
G
K
N
A
ALG
N
VVIS
L
FF
MLG
C
-----
I
PP
M
L
WL
N
TAG
RR
PL
L
I
GS
F
AM
M
TLA
LAVLG
L
IP
D
M
G
IW
--------
LVVM
A
F
A
-
VY
AF
F
S
GG
PG
NL
QW
LYP
N
ELFPTDIR
AS
A
VG
V
IM
S
LSRIG
T
I
VST
WA
LP
I
------
F
I
N
N
YG
-
I
S
N
TML
M
GA
G
I
S
L
F
GL
L
IS
VA
FAPETR
G
MSL
AQT
SN
M
TIRGQRMG
fig|216593.1.peg.3532
Escherichia coli E2348/69
MQPSRNFDDL
KF
S
SI
H
R
RI
LLWG
SG
GP
F
LDGYVL
VM
IGVAL
E
QLTPA
LK
L
DA
D
WI
G
LL
G
AGT
L
A
GLFVG
TS
LF
GYISD
KV
GRRK
M
F
L
ID
I
I
A
IGV
I
S
VATM
FV
SS
P
VE
L
L
VM
R
V
LIGI
V
IGADY
P
IA
T
S
MI
TEFS
S
T
R
Q
R
A
FSISFIA
--------
AM
W
Y
VG
ATC
A
D
L
VG
-
YWLYDVEGG
WRWML
G
SAAIP
C
LLI
LIG
R
F
EL
--------------------
PESPRWLLRKGR
V
K
E
C
E
EV
M
I
K
L
FG
EP
V
AFEE
EQ
PQQ
T
-
-
R
F
R
-----
--
--------------
D
LF
NR
R
HF
PFV
LF
VAAIWT
C
Q
--
VIP
M
F
A
IYT
F
G
P
Q
I
VGLL
GL
G
V
G
K
N
A
ALG
N
VVIS
L
FF
MLG
C
-----
I
PP
M
L
WL
N
TAG
RR
PL
L
I
GS
F
AM
M
TLA
LAVLG
L
IP
D
M
G
IW
--------
LVVM
A
F
A
-
VY
AF
F
S
GG
PG
NL
QW
LYP
N
ELFPTDIR
AS
A
VG
V
IM
F
LSRIG
T
I
VST
WA
LP
I
------
F
I
N
N
YG
-
I
S
N
TML
M
GA
G
I
S
L
F
GL
L
IS
VA
FAPETR
G
MSL
AQT
SN
M
TIRGQRMG
fig|574521.7.peg.48
Escherichia coli O127:H6 str. E2348/69
MQPSRNFDDL
KF
S
SI
H
R
RI
LLWG
SG
GP
F
LDGYVL
VM
IGVAL
E
QLTPA
LK
L
DA
D
WI
G
LL
G
AGT
L
A
GLFVG
TS
LF
GYISD
KV
GRRK
M
F
L
ID
I
I
A
IGV
I
S
VATM
FV
SS
P
VE
L
L
VM
R
V
LIGI
V
IGADY
P
IA
T
S
MI
TEFS
S
T
R
Q
R
A
FSISFIA
--------
AM
W
Y
VG
ATC
A
D
L
VG
-
YWLYDVEGG
WRWML
G
SAAIP
C
LLI
LIG
R
F
EL
--------------------
PESPRWLLRKGR
V
K
E
C
E
EV
M
I
K
L
FG
EP
V
AFEE
EQ
PQQ
T
-
-
R
F
R
-----
--
--------------
D
LF
NR
R
HF
PFV
LF
VAAIWT
C
Q
--
VIP
M
F
A
IYT
F
G
P
Q
I
VGLL
GL
G
V
G
K
N
A
ALG
N
VVIS
L
FF
MLG
C
-----
I
PP
M
L
WL
N
TAG
RR
PL
L
I
GS
F
AM
M
TLA
LAVLG
L
IP
D
M
G
IW
--------
LVVM
A
F
A
-
VY
AF
F
S
GG
PG
NL
QW
LYP
N
ELFPTDIR
AS
A
VG
V
IM
F
LSRIG
T
I
VST
WA
LP
I
------
F
I
N
N
YG
-
I
S
N
TML
M
GA
G
I
S
L
F
GL
L
IS
VA
FAPETR
G
MSL
AQT
SN
M
TIRGQRMG
fig|478008.5.peg.477
Escherichia coli O157:H7 str. EC869
MQPSRNFDDL
KF
S
SI
H
R
RI
LLWG
SG
GP
F
LDGY
I
L
VM
IGVAL
E
QLTPA
LK
L
DA
D
WI
G
LL
G
AGT
L
A
GLFVG
TS
LF
GYISD
KV
GRRK
M
F
L
ID
I
I
A
IGV
I
S
VATM
FV
SS
P
VE
L
L
VM
R
V
LIGI
V
IGADY
P
IA
T
S
MI
TEFS
S
T
R
H
R
A
FSISFIA
--------
AM
W
Y
VG
ATC
A
D
L
VG
-
YWLYDVEGG
WRWML
G
SAAIP
C
LLI
LIG
R
F
EL
--------------------
PESPRWLLRKGR
V
K
E
C
E
EM
M
I
K
L
FG
GP
V
AFDE
EQ
PQQ
T
-
-
R
F
R
-----
--
--------------
D
LF
NR
R
HF
PFV
LF
VAAIWT
C
Q
--
VIP
M
F
A
IYT
F
G
P
Q
I
VGLL
GL
G
V
G
K
N
A
ALG
N
VVIS
L
FF
MLG
C
-----
I
PP
M
L
WL
N
TAG
RR
PL
L
I
GS
F
AM
M
TLA
LAVLG
L
IP
D
M
G
IW
--------
LVVM
A
L
A
-
VY
AF
F
S
GG
PG
NL
QW
LYP
N
ELFPTDIR
AS
A
VG
V
IM
S
LSRIG
T
I
VST
WA
LP
I
------
F
I
N
N
YG
-
I
S
N
TML
M
GA
G
I
S
L
F
GL
L
IS
VA
FAPETR
G
MSL
AQT
SN
M
TIRGQRMG
fig|637388.3.peg.3886
Escherichia coli O157:H7 str. FRIK2000
MQPSRNFDDL
KF
S
SI
H
R
RI
LLWG
SG
GP
F
LDGY
I
L
VM
IGVAL
E
QLTPA
LK
L
DA
D
WI
G
LL
G
AGT
L
A
GLFVG
TS
LF
GYISD
KV
GRRK
M
F
L
ID
I
I
A
IGV
I
S
VATM
FV
SS
P
VE
L
L
VM
R
V
LIGI
V
IGADY
P
IA
T
S
MI
TEFS
S
T
R
H
R
A
FSISFIA
--------
AM
W
Y
VG
ATC
A
D
L
VG
-
YWLYDVEGG
WRWML
G
SAAIP
C
LLI
LIG
R
F
EL
--------------------
PESPRWLLRKGR
V
K
E
C
E
EM
M
I
K
L
FG
GP
V
AFDE
EQ
PQQ
T
-
-
R
F
R
-----
--
--------------
D
LF
NR
R
HF
PFV
LF
VAAIWT
C
Q
--
VIP
M
F
A
IYT
F
G
P
Q
I
VGLL
GL
G
V
G
K
N
A
ALG
N
VVIS
L
FF
MLG
C
-----
I
PP
M
L
WL
N
TAG
RR
PL
L
I
GS
F
AM
M
TLA
LAVLG
L
IP
D
M
G
IW
--------
LVVM
A
L
A
-
VY
AF
F
S
GG
PG
NL
QW
LYP
N
ELFPTDIR
AS
A
VG
V
IM
S
LSRIG
T
I
VST
WA
LP
I
------
F
I
N
N
YG
-
I
S
N
TML
M
GA
G
I
S
L
F
GL
L
IS
VA
FAPETR
G
MSL
AQT
SN
M
TIRGQRMG
fig|570506.3.peg.1050
Escherichia coli O157:H7 str. FRIK966
MQPSRNFDDL
KF
S
SI
H
R
RI
LLWG
SG
GP
F
LDGY
I
L
VM
IGVAL
E
QLTPA
LK
L
DA
D
WI
G
LL
G
AGT
L
A
GLFVG
TS
LF
GYISD
KV
GRRK
M
F
L
ID
I
I
A
IGV
I
S
VATM
FV
SS
P
VE
L
L
VM
R
V
LIGI
V
IGADY
P
IA
T
S
MI
TEFS
S
T
R
H
R
A
FSISFIA
--------
AM
W
Y
VG
ATC
A
D
L
VG
-
YWLYDVEGG
WRWML
G
SAAIP
C
LLI
LIG
R
F
EL
--------------------
PESPRWLLRKGR
V
K
E
C
E
EM
M
I
K
L
FG
GP
V
AFDE
EQ
PQQ
T
-
-
R
F
R
-----
--
--------------
D
LF
NR
R
HF
PFV
LF
VAAIWT
C
Q
--
VIP
M
F
A
IYT
F
G
P
Q
I
VGLL
GL
G
V
G
K
N
A
ALG
N
VVIS
L
FF
MLG
C
-----
I
PP
M
L
WL
N
TAG
RR
PL
L
I
GS
F
AM
M
TLA
LAVLG
L
IP
D
M
G
IW
--------
LVVM
A
L
A
-
VY
AF
F
S
GG
PG
NL
QW
LYP
N
ELFPTDIR
AS
A
VG
V
IM
S
LSRIG
T
I
VST
WA
LP
I
------
F
I
N
N
YG
-
I
S
N
TML
M
GA
G
I
S
L
F
GL
L
IS
VA
FAPETR
G
MSL
AQT
SN
M
TIRGQRMG
fig|749537.3.peg.4812
Escherichia coli MS 115-1 (9-435/445)
DDLPL
N
RFH
C
RI
AALT
F
G
AH
L
T
DGYVL
GV
IG
Y
A
I
I
QLTPA
MQ
L
TP
F
MA
G
MI
G
GSA
L
L
GLF
L
GSL
VL
G
W
ISD
HI
GR
Q
K
I
F
T
F
S
F
L
L
I
T
L
AS
FLQF
F
A
TT
P
EH
LI
GL
R
I
LIGIG
L
G
G
DY
S
VG
H
T
LL
A
EFSP
R
R
H
RG
ILLGAFS
--------
VV
W
T
VG
YVL
AS
I
A
G
H
HFISENPEA
WRW
L
L
A
SAA
L
P
P
LLI
TLL
RW
GT
--------------------
PESPRWLLR
Q
GR
F
AEA
H
AI
V
H
R
Y
FG
PH
V
LLGD
E
V
VTA
T
H
K
H
I
K
-----
--
--------------
T
LF
SS
R
YW
RRT
A
F
NSVFFV
C
L
--
VIP
W
F
V
IYTW
L
PTI
AQTI
GL
-
-
-
E
D
A
LTA
S
LMLN
A
LL
I
V
GA
-----
L
LG
L
V
LT
H
LLA
H
R
KF
L
L
GS
F
LL
L
AAT
L
V
V
MA
C
L
PS
-
G
SS
--------
L
T
LL
L
F
V
-
L
F
ST
T
I
SA
VS
NL
VG
I
L
P
A
E
S
FPTDIR
SL
GVGF
AT
A
M
SR
L
GA
A
VST
GL
LP
W
------
V
L
A
Q
W
G
-
M
Q
VT
L
LL
L
A
T
V
L
L
V
G
F
V
V
T
WL
W
APET
K
A
L
P
L
VAA
G
NV
fig|358709.5.peg.3660
Escherichia coli 101-1 (33-459/469)
DDLPL
N
RFH
C
RI
AALT
F
G
AH
L
T
DGYVL
GV
IG
Y
A
I
I
QLTPA
MQ
L
TP
F
MA
G
MI
G
GSA
L
L
GLF
L
GSL
VL
G
W
ISD
HI
GR
Q
K
I
F
T
F
S
F
L
L
I
T
L
AS
FLQF
F
A
TT
P
EH
LI
GL
R
I
LIGIG
L
G
G
DY
S
VG
H
T
LL
A
EFSP
R
R
H
RG
ILLGAFS
--------
VV
W
T
VG
YVL
AS
I
A
G
H
HFISENPEA
WRW
L
L
A
SAA
L
P
A
LLI
TLL
RW
GT
--------------------
PESPRWLLR
Q
GR
F
AEA
H
AI
V
H
R
Y
FG
PH
V
LLGD
E
V
VTA
T
H
K
H
I
K
-----
--
--------------
T
LF
SS
R
YW
RRT
A
F
NSVFFV
C
L
--
VIP
W
F
V
IYTW
L
PTI
AQTI
GL
-
-
-
E
D
A
LTA
S
LMLN
A
LL
I
V
GA
-----
L
LG
L
V
LT
H
LLA
H
R
KF
L
L
GS
F
LL
L
AAT
L
V
V
MA
C
L
PS
-
G
SS
--------
L
T
LL
L
F
V
-
L
F
ST
T
I
SA
VS
NL
VG
I
L
P
A
E
S
FPTDIR
SL
GVGF
AT
A
M
SR
L
GA
A
VST
GL
LP
W
------
V
L
A
Q
W
G
-
M
Q
VT
L
L
I
L
A
T
V
L
L
V
G
F
V
V
T
WL
W
APET
K
A
L
P
L
VAA
G
NV
fig|656393.3.peg.3769
Escherichia coli H299 (9-435/445)
DDLPL
N
RFH
C
RI
AALT
F
G
AH
L
T
DGYVL
GV
IG
Y
A
I
I
QLTPA
MQ
L
TP
F
MA
G
MI
G
GSA
L
L
GLF
I
GSL
VL
G
W
ISD
HI
GR
Q
K
I
F
T
F
S
F
L
L
I
T
L
AS
FLQF
F
A
TT
P
EH
LI
GL
R
I
LIGIG
L
G
G
DY
S
VG
H
T
LL
A
EFSP
R
R
H
RG
VLLGAFS
--------
VV
W
T
VG
YVL
AS
I
A
G
H
HFISESPEA
WRW
L
L
A
SAA
L
P
A
LLI
TLL
RW
GT
--------------------
PESPRWLLR
Q
GR
F
AEA
H
AI
V
H
R
Y
FG
PH
V
LLGD
E
V
ATA
T
H
K
H
I
K
-----
--
--------------
T
LF
SS
R
YW
RRT
A
F
NSVFFV
C
L
--
VIP
W
F
V
IYTW
L
PTI
AQTI
GL
-
-
-
E
D
A
LTA
N
LMLN
A
LL
I
V
GA
-----
L
LG
L
V
LT
H
LLA
H
R
KF
L
L
GS
F
LL
L
AAT
L
V
V
MA
C
L
PS
-
G
SS
--------
L
T
LL
L
F
V
-
L
F
ST
T
I
SA
VS
NL
VG
I
L
P
A
E
S
FPTDIR
SL
GVGF
AT
A
M
SR
L
GA
A
VST
GL
LP
W
------
V
L
A
Q
W
G
-
M
Q
VT
L
LL
L
A
A
V
L
L
V
G
F
V
V
T
WL
W
APET
K
A
L
P
L
VAA
G
NV
fig|199310.1.peg.3251
Escherichia coli CFT073 (33-459/469)
DDLPL
N
RFH
C
RI
AALT
F
G
AH
L
T
DGYVL
GV
IG
Y
A
I
I
QLTPA
MQ
L
TP
F
MA
G
MI
G
GSA
L
L
GLF
L
GSL
VL
G
W
ISD
HI
GR
Q
K
I
F
T
F
S
F
M
L
I
T
L
AS
FLQF
F
A
TT
P
EH
LI
GL
R
I
LIGIG
L
G
G
DY
S
VG
H
T
LL
A
EFSP
R
R
H
RG
ILLGAFS
--------
VV
W
T
VG
YVL
AS
I
A
G
H
HFISESPEA
WRW
L
L
A
SAA
L
P
A
LLI
TLL
RW
GT
--------------------
PESPRWLLR
Q
GR
F
AEA
H
AI
V
H
R
Y
FG
PH
V
LLGD
E
V
ATA
T
H
K
H
I
K
-----
--
--------------
T
LF
SS
R
YW
RRT
A
F
NSVFFV
C
L
--
VIP
W
F
V
IYTW
L
PTI
AQTI
GL
-
-
-
E
D
A
LTA
S
LMLN
A
LL
I
V
GA
-----
L
LG
L
V
LT
H
LLA
H
R
RF
L
L
GS
F
LL
L
TAT
L
V
V
MA
C
L
PS
-
G
SS
--------
L
T
LL
L
F
V
-
L
F
ST
T
I
SA
VS
NL
VG
I
L
P
A
E
S
FPTDIR
SL
GVGF
AT
A
M
SR
L
GA
A
VST
GL
LP
W
------
V
L
A
Q
W
G
-
M
Q
A
T
L
LL
L
A
A
V
L
L
V
G
F
V
V
T
WL
W
APET
K
A
L
P
L
VAA
G
NV
fig|656417.3.peg.3515
Escherichia coli M605 (9-438/449)
DDLPL
N
RFH
C
RI
AALT
F
G
AH
L
T
DGYVL
GV
IG
Y
A
I
I
QLTPA
MQ
L
TP
F
MA
G
MI
G
GSA
L
L
GLF
L
GSL
VL
G
W
ISD
HI
GR
Q
K
I
F
T
F
S
F
M
L
I
T
L
AS
FLQF
F
A
TT
P
EH
LI
GL
R
I
LIGIG
L
G
G
DY
S
VG
H
T
LL
A
EFSP
R
R
H
RG
ILLGAFS
--------
VV
W
T
VG
YVL
AS
I
A
G
H
HFISESPEA
WRW
L
L
A
SAA
L
P
A
LLI
TLL
RW
GT
--------------------
PESPRWLLR
Q
GR
F
AEA
H
AI
V
H
R
Y
FG
PH
V
LLGD
E
V
ATA
T
H
K
H
I
K
-----
--
--------------
T
LF
SS
R
YW
RRT
A
F
NSVFFV
C
L
--
VIP
W
F
V
IYTW
L
PTI
AQTI
GL
-
-
-
E
D
A
LTA
S
LMLN
A
LL
I
V
GA
-----
L
LG
L
V
LT
H
LLA
H
R
RF
L
L
GS
F
LL
L
TAT
L
V
V
MA
C
L
PS
-
G
SS
--------
L
T
LL
L
F
V
-
L
F
ST
T
I
SA
VS
NL
VG
I
L
P
A
E
S
FPTDIR
SL
GVGF
AT
A
M
SR
L
GA
A
VST
GL
LP
W
------
V
L
A
Q
W
G
-
M
P
VT
L
LL
L
A
A
V
L
L
V
G
F
V
V
T
WL
W
APET
K
A
L
P
L
VAA
G
NV
EQ
R
fig|525281.3.peg.4503
Escherichia coli 83972 (9-435/445)
DDLPL
N
RFH
C
RI
AALT
F
G
AH
L
T
DGYVL
GV
IG
Y
A
I
I
QLTPA
MQ
L
TP
F
MA
G
MI
G
GSA
L
L
GLF
L
GSL
VL
G
W
ISD
HI
GR
Q
K
I
F
T
F
S
F
M
L
I
T
L
AS
FLQF
F
A
TT
P
EH
LI
GL
R
I
LIGIG
L
G
G
DY
S
VG
H
T
LL
A
EFSP
R
R
H
RG
ILLGAFS
--------
VV
W
T
VG
YVL
AS
I
A
G
H
HFISESPEA
WRW
L
L
A
SAA
L
P
A
LLI
TLL
RW
GT
--------------------
PESPRWLLR
Q
GR
F
AEA
H
AI
V
H
R
Y
FG
PH
V
LLGD
E
V
ATA
T
H
K
H
I
K
-----
--
--------------
T
LF
SS
R
YW
RRT
A
F
NSVFFV
C
L
--
VIP
W
F
V
IYTW
L
PTI
AQTI
GL
-
-
-
E
D
A
LTA
S
LMLN
A
LL
I
V
GA
-----
L
LG
L
V
LT
H
LLA
H
R
RF
L
L
GS
F
LL
L
TAT
L
V
V
MA
C
L
PS
-
G
SS
--------
L
T
LL
L
F
V
-
L
F
ST
T
I
SA
VS
NL
VG
I
L
P
A
E
S
FPTDIR
SL
GVGF
AT
A
M
SR
L
GA
A
VST
GL
LP
W
------
V
L
A
Q
W
G
-
M
Q
A
T
L
LL
L
A
A
V
L
L
V
G
F
V
V
T
WL
W
APET
K
A
L
P
L
VAA
G
NV
fig|655817.3.peg.3159
Escherichia coli ABU 83972 (9-435/445)
DDLPL
N
RFH
C
RI
AALT
F
G
AH
L
T
DGYVL
GV
IG
Y
A
I
I
QLTPA
MQ
L
TP
F
MA
G
MI
G
GSA
L
L
GLF
L
GSL
VL
G
W
ISD
HI
GR
Q
K
I
F
T
F
S
F
M
L
I
T
L
AS
FLQF
F
A
TT
P
EH
LI
GL
R
I
LIGIG
L
G
G
DY
S
VG
H
T
LL
A
EFSP
R
R
H
RG
ILLGAFS
--------
VV
W
T
VG
YVL
AS
I
A
G
H
HFISESPEA
WRW
L
L
A
SAA
L
P
A
LLI
TLL
RW
GT
--------------------
PESPRWLLR
Q
GR
F
AEA
H
AI
V
H
R
Y
FG
PH
V
LLGD
E
V
ATA
T
H
K
H
I
K
-----
--
--------------
T
LF
SS
R
YW
RRT
A
F
NSVFFV
C
L
--
VIP
W
F
V
IYTW
L
PTI
AQTI
GL
-
-
-
E
D
A
LTA
S
LMLN
A
LL
I
V
GA
-----
L
LG
L
V
LT
H
LLA
H
R
RF
L
L
GS
F
LL
L
TAT
L
V
V
MA
C
L
PS
-
G
SS
--------
L
T
LL
L
F
V
-
L
F
ST
T
I
SA
VS
NL
VG
I
L
P
A
E
S
FPTDIR
SL
GVGF
AT
A
M
SR
L
GA
A
VST
GL
LP
W
------
V
L
A
Q
W
G
-
M
Q
A
T
L
LL
L
A
A
V
L
L
V
G
F
V
V
T
WL
W
APET
K
A
L
P
L
VAA
G
NV
fig|199310.4.peg.3139
Escherichia coli CFT073 (9-435/445)
DDLPL
N
RFH
C
RI
AALT
F
G
AH
L
T
DGYVL
GV
IG
Y
A
I
I
QLTPA
MQ
L
TP
F
MA
G
MI
G
GSA
L
L
GLF
L
GSL
VL
G
W
ISD
HI
GR
Q
K
I
F
T
F
S
F
M
L
I
T
L
AS
FLQF
F
A
TT
P
EH
LI
GL
R
I
LIGIG
L
G
G
DY
S
VG
H
T
LL
A
EFSP
R
R
H
RG
ILLGAFS
--------
VV
W
T
VG
YVL
AS
I
A
G
H
HFISESPEA
WRW
L
L
A
SAA
L
P
A
LLI
TLL
RW
GT
--------------------
PESPRWLLR
Q
GR
F
AEA
H
AI
V
H
R
Y
FG
PH
V
LLGD
E
V
ATA
T
H
K
H
I
K
-----
--
--------------
T
LF
SS
R
YW
RRT
A
F
NSVFFV
C
L
--
VIP
W
F
V
IYTW
L
PTI
AQTI
GL
-
-
-
E
D
A
LTA
S
LMLN
A
LL
I
V
GA
-----
L
LG
L
V
LT
H
LLA
H
R
RF
L
L
GS
F
LL
L
TAT
L
V
V
MA
C
L
PS
-
G
SS
--------
L
T
LL
L
F
V
-
L
F
ST
T
I
SA
VS
NL
VG
I
L
P
A
E
S
FPTDIR
SL
GVGF
AT
A
M
SR
L
GA
A
VST
GL
LP
W
------
V
L
A
Q
W
G
-
M
Q
A
T
L
LL
L
A
A
V
L
L
V
G
F
V
V
T
WL
W
APET
K
A
L
P
L
VAA
G
NV
fig|585397.7.peg.3229
Escherichia coli ED1a (9-435/445)
DDLPL
N
RFH
C
RI
AALT
F
G
AH
L
T
DGYVL
GV
IG
Y
A
I
I
QLTPA
MQ
L
TP
F
MA
G
MI
G
GSA
L
L
GLF
L
GSL
VL
G
W
ISD
HI
GR
Q
K
I
F
T
F
S
F
M
L
I
T
L
AS
FLQF
F
A
TT
P
EH
LI
GL
R
I
LIGIG
L
G
G
DY
S
VG
H
T
LL
A
EFSP
R
R
H
RG
ILLGAFS
--------
VV
W
T
VG
YVL
AS
I
A
G
H
HFISESPEA
WRW
L
L
A
SAA
L
P
A
LLI
TLL
RW
GT
--------------------
PESPRWLLR
Q
GR
F
AEA
H
AI
V
H
R
Y
FG
PH
V
LLGD
E
V
ATA
T
H
K
H
I
K
-----
--
--------------
T
LF
SS
R
YW
RRT
A
F
NSVFFV
C
L
--
VIP
W
F
V
IYTW
L
PTI
AQTI
GL
-
-
-
E
D
A
LTA
S
LMLN
A
LL
I
V
GA
-----
L
LG
L
V
LT
H
LLA
H
R
RF
L
L
GS
F
LL
L
TAT
L
V
V
MA
C
L
PS
-
G
SS
--------
L
T
LL
L
F
V
-
L
F
ST
T
I
SA
VS
NL
VG
I
L
P
A
E
S
FPTDIR
SL
GVGF
AT
A
M
SR
L
GA
A
VST
GL
LP
W
------
V
L
A
Q
W
G
-
M
Q
A
T
L
LL
L
A
A
V
L
L
V
G
F
V
V
T
WL
W
APET
K
A
L
P
L
VAA
G
NV
fig|585397.9.peg.3225
Escherichia coli ED1a (9-435/445)
DDLPL
N
RFH
C
RI
AALT
F
G
AH
L
T
DGYVL
GV
IG
Y
A
I
I
QLTPA
MQ
L
TP
F
MA
G
MI
G
GSA
L
L
GLF
L
GSL
VL
G
W
ISD
HI
GR
Q
K
I
F
T
F
S
F
M
L
I
T
L
AS
FLQF
F
A
TT
P
EH
LI
GL
R
I
LIGIG
L
G
G
DY
S
VG
H
T
LL
A
EFSP
R
R
H
RG
ILLGAFS
--------
VV
W
T
VG
YVL
AS
I
A
G
H
HFISESPEA
WRW
L
L
A
SAA
L
P
A
LLI
TLL
RW
GT
--------------------
PESPRWLLR
Q
GR
F
AEA
H
AI
V
H
R
Y
FG
PH
V
LLGD
E
V
ATA
T
H
K
H
I
K
-----
--
--------------
T
LF
SS
R
YW
RRT
A
F
NSVFFV
C
L
--
VIP
W
F
V
IYTW
L
PTI
AQTI
GL
-
-
-
E
D
A
LTA
S
LMLN
A
LL
I
V
GA
-----
L
LG
L
V
LT
H
LLA
H
R
RF
L
L
GS
F
LL
L
TAT
L
V
V
MA
C
L
PS
-
G
SS
--------
L
T
LL
L
F
V
-
L
F
ST
T
I
SA
VS
NL
VG
I
L
P
A
E
S
FPTDIR
SL
GVGF
AT
A
M
SR
L
GA
A
VST
GL
LP
W
------
V
L
A
Q
W
G
-
M
Q
A
T
L
LL
L
A
A
V
L
L
V
G
F
V
V
T
WL
W
APET
K
A
L
P
L
VAA
G
NV
fig|749546.3.peg.3146
Escherichia coli MS 185-1 (9-435/445)
DDLPL
N
RFH
C
RI
AALT
F
G
AH
L
T
DGYVL
GV
IG
Y
A
I
I
QLTPA
MQ
L
TP
F
MA
G
MI
G
GSA
L
L
GLF
L
GSL
VL
G
W
ISD
HI
GR
Q
K
I
F
T
F
S
F
M
L
I
T
L
AS
FLQF
F
A
TT
P
EH
LI
GL
R
I
LIGIG
L
G
G
DY
S
VG
H
T
LL
A
EFSP
R
R
H
RG
ILLGAFS
--------
VV
W
T
VG
YVL
AS
I
A
G
H
HFISESPEA
WRW
L
L
A
SAA
L
P
A
LLI
TLL
RW
GT
--------------------
PESPRWLLR
Q
GR
F
AEA
H
AI
V
H
R
Y
FG
PH
V
LLGD
E
V
ATA
T
H
K
H
I
K
-----
--
--------------
T
LF
SS
R
YW
RRT
A
F
NSVFFV
C
L
--
VIP
W
F
V
IYTW
L
PTI
AQTI
GL
-
-
-
E
D
A
LTA
S
LMLN
A
LL
I
V
GA
-----
L
LG
L
V
LT
H
LLA
H
R
RF
L
L
GS
F
LL
L
TAT
L
V
V
MA
C
L
PS
-
G
SS
--------
L
T
LL
L
F
V
-
L
F
ST
T
I
SA
VS
NL
VG
I
L
P
A
E
S
FPTDIR
SL
GVGF
AT
A
M
SR
L
GA
A
VST
GL
LP
W
------
V
L
A
Q
W
G
-
M
Q
A
T
L
LL
L
A
A
V
L
L
V
G
F
V
V
T
WL
W
APET
K
A
L
P
L
VAA
G
NV
fig|749528.3.peg.1283
Escherichia coli MS 45-1 (9-435/445)
DDLPL
N
RFH
C
RI
AALT
F
G
AH
L
T
DGYVL
GV
IG
Y
A
I
I
QLTPA
MQ
L
TP
F
MA
G
MI
G
GSA
L
L
GLF
L
GSL
VL
G
W
ISD
HI
GR
Q
K
I
F
T
F
S
F
M
L
I
T
L
AS
FLQF
F
A
TT
P
EH
LI
GL
R
I
LIGIG
L
G
G
DY
S
VG
H
T
LL
A
EFSP
R
R
H
RG
ILLGAFS
--------
VV
W
T
VG
YVL
AS
I
A
G
H
HFISESPEA
WRW
L
L
A
SAA
L
P
A
LLI
TLL
RW
GT
--------------------
PESPRWLLR
Q
GR
F
AEA
H
AI
V
H
R
Y
FG
PH
V
LLGD
E
V
ATA
T
H
K
H
I
K
-----
--
--------------
T
LF
SS
R
YW
RRT
A
F
NSVFFV
C
L
--
VIP
W
F
V
IYTW
L
PTI
AQTI
GL
-
-
-
E
D
A
LTA
S
LMLN
A
LL
I
V
GA
-----
L
LG
L
V
LT
H
LLA
H
R
RF
L
L
GS
F
LL
L
TAT
L
V
V
MA
C
L
PS
-
G
SS
--------
L
T
LL
L
F
V
-
L
F
ST
T
I
SA
VS
NL
VG
I
L
P
A
E
S
FPTDIR
SL
GVGF
AT
A
M
SR
L
GA
A
VST
GL
LP
W
------
V
L
A
Q
W
G
-
M
Q
A
T
L
LL
L
A
A
V
L
L
V
G
F
V
V
T
WL
W
APET
K
A
L
P
L
VAA
G
NV
fig|685038.3.peg.2761
Escherichia coli O83:H1 str. NRG 857C (9-435/445)
DDLPL
N
RFH
C
RI
AALT
F
G
AH
L
T
DGYVL
GV
IG
Y
A
I
I
QLTPA
MQ
L
TP
F
MA
G
MI
G
GSA
L
L
GLF
L
GSL
VL
G
W
ISD
HI
GR
Q
K
I
F
T
F
S
F
M
L
I
T
L
AS
FLQF
F
A
TT
P
EH
LI
GL
R
I
LIGIG
L
G
G
DY
S
VG
H
T
LL
A
EFSP
R
R
H
RG
ILLGAFS
--------
VV
W
T
VG
YVL
AS
I
A
G
H
HFISESPEA
WRW
L
L
A
SAA
L
P
A
LLI
TLL
RW
GT
--------------------
PESPRWLLR
Q
GR
F
AEA
H
AI
V
H
R
Y
FG
PH
V
LLGD
E
V
ATA
T
H
K
H
I
K
-----
--
--------------
T
LF
SS
R
YW
RRT
A
F
NSVFFV
C
L
--
VIP
W
F
V
IYTW
L
PTI
AQTI
GL
-
-
-
E
D
A
LTA
S
LMLN
A
LL
I
V
GA
-----
L
LG
L
V
LT
H
LLA
H
R
RF
L
L
GS
F
LL
L
TAT
L
V
V
MA
C
L
PS
-
G
SS
--------
L
T
LL
L
F
V
-
L
F
ST
T
I
SA
VS
NL
VG
I
L
P
A
E
S
FPTDIR
SL
GVGF
AT
A
M
SR
L
GA
A
VST
GL
LP
W
------
V
L
A
Q
W
G
-
M
Q
A
T
L
LL
L
A
A
V
L
L
V
G
F
V
V
T
WL
W
APET
K
A
L
P
L
VAA
G
NV
fig|749527.3.peg.1334
Escherichia coli MS 21-1 (9-435/445)
DDLPL
N
RFH
C
RI
AALT
F
G
AH
L
T
DGYVL
GV
IG
Y
A
I
I
QLTPA
MQ
L
TP
L
MA
G
MI
G
GSA
L
L
GLF
L
GSL
VL
G
W
ISD
HI
GR
Q
K
I
F
T
F
S
F
L
L
I
T
L
AS
LLQF
F
A
TT
P
EH
LI
GL
R
I
LIGIG
L
G
G
DY
S
VG
H
T
LL
A
EFSP
R
R
H
RG
ILLGAFS
--------
VV
W
T
VG
YVL
AS
I
A
G
H
HFITESPEA
WRW
L
L
A
SAA
L
P
A
LLI
TLL
RW
GT
--------------------
PESPRWLLR
Q
GR
F
AEA
H
AI
V
H
R
Y
FG
PH
V
LLGD
E
V
ATA
T
H
K
H
I
K
-----
--
--------------
T
LF
SS
R
YW
RRT
A
F
NSVFFV
C
L
--
VIP
W
F
V
IYTW
L
PTI
AQTI
GL
-
-
-
E
D
A
LTA
S
LMLN
A
LL
I
V
GA
-----
L
LG
L
V
LT
H
LLA
H
R
KF
L
L
GS
F
LL
L
AAT
L
V
V
MA
C
L
PS
-
G
SS
--------
L
T
LL
L
F
V
-
L
F
ST
T
I
SA
VS
NL
VG
I
L
P
A
E
S
FPTDIR
SL
GVGF
AT
A
M
SR
L
GA
A
VST
GL
LP
W
------
V
L
A
Q
W
G
-
M
Q
A
T
L
LL
L
A
A
V
L
L
V
G
F
V
V
T
WL
W
APET
K
A
L
P
L
VAA
G
NV
fig|714962.3.peg.3180
Escherichia coli IHE3034 (9-434/445)
DDLPL
N
RFH
C
RI
AALT
F
G
AH
L
T
DGYVL
GV
IG
Y
A
I
I
QLTPA
MQ
L
TP
F
MA
G
MI
G
GSA
L
L
GLF
L
GSL
VL
G
W
ISD
HI
GR
Q
K
I
F
T
F
S
F
M
L
I
T
L
AS
FLQF
F
A
TT
P
EH
LI
GL
R
I
LIGIG
L
G
G
DY
S
VG
H
T
LL
A
EFSP
R
R
H
RG
VLLGAFS
--------
VV
W
T
VG
YVL
AS
I
A
G
H
HFISESPEA
WRW
L
L
A
SAA
L
P
A
LLI
TLL
RW
GT
--------------------
PESPRWLLR
Q
GR
F
AEA
H
AI
V
H
R
Y
FG
PH
V
LLGD
E
V
ATA
T
H
K
H
I
K
-----
--
--------------
T
LF
SS
R
YW
RRT
A
F
NSVFFV
C
L
--
VIP
W
F
V
IYTW
L
PTI
AQTI
GL
-
-
-
E
D
A
LTA
S
LMLN
A
LL
I
V
GA
-----
L
LG
L
V
LT
H
LLA
H
R
RF
L
L
GS
F
LL
L
TAT
L
V
V
MA
C
L
PS
-
G
SS
--------
L
T
LL
L
F
V
-
L
F
ST
T
I
SA
VS
NL
VG
I
L
P
A
E
S
FPTDIR
SL
GVGF
AT
A
M
SR
L
GA
A
VST
GL
LP
W
------
V
L
A
Q
W
G
-
M
Q
A
T
L
LL
L
A
A
V
L
L
V
G
F
V
V
T
WL
W
APET
K
A
L
P
L
VAA
G
N
fig|585035.6.peg.2978
Escherichia coli S88 (9-434/445)
DDLPL
N
RFH
C
RI
AALT
F
G
AH
L
T
DGYVL
GV
IG
Y
A
I
I
QLTPA
MQ
L
TP
F
MA
G
MI
G
GSA
L
L
GLF
L
GSL
VL
G
W
ISD
HI
GR
Q
K
I
F
T
F
S
F
M
L
I
T
L
AS
FLQF
F
A
TT
P
EH
LI
GL
R
I
LIGIG
L
G
G
DY
S
VG
H
T
LL
A
EFSP
R
R
H
RG
VLLGAFS
--------
VV
W
T
VG
YVL
AS
I
A
G
H
HFISESPEA
WRW
L
L
A
SAA
L
P
A
LLI
TLL
RW
GT
--------------------
PESPRWLLR
Q
GR
F
AEA
H
AI
V
H
R
Y
FG
PH
V
LLGD
E
V
ATA
T
H
K
H
I
K
-----
--
--------------
T
LF
SS
R
YW
RRT
A
F
NSVFFV
C
L
--
VIP
W
F
V
IYTW
L
PTI
AQTI
GL
-
-
-
E
D
A
LTA
S
LMLN
A
LL
I
V
GA
-----
L
LG
L
V
LT
H
LLA
H
R
RF
L
L
GS
F
LL
L
TAT
L
V
V
MA
C
L
PS
-
G
SS
--------
L
T
LL
L
F
V
-
L
F
ST
T
I
SA
VS
NL
VG
I
L
P
A
E
S
FPTDIR
SL
GVGF
AT
A
M
SR
L
GA
A
VST
GL
LP
W
------
V
L
A
Q
W
G
-
M
Q
A
T
L
LL
L
A
A
V
L
L
V
G
F
V
V
T
WL
W
APET
K
A
L
P
L
VAA
G
N
fig|869729.3.peg.588
Escherichia coli UM146 (9-434/445)
DDLPL
N
RFH
C
RI
AALT
F
G
AH
L
T
DGYVL
GV
IG
Y
A
I
I
QLTPA
MQ
L
TP
F
MA
G
MI
G
GSA
L
L
GLF
L
GSL
VL
G
W
ISD
HI
GR
Q
K
I
F
T
F
S
F
M
L
I
T
L
AS
FLQF
F
A
TT
P
EH
LI
GL
R
I
LIGIG
L
G
G
DY
S
VG
H
T
LL
A
EFSP
R
R
H
RG
VLLGAFS
--------
VV
W
T
VG
YVL
AS
I
A
G
H
HFISESPEA
WRW
L
L
A
SAA
L
P
A
LLI
TLL
RW
GT
--------------------
PESPRWLLR
Q
GR
F
AEA
H
AI
V
H
R
Y
FG
PH
V
LLGD
E
V
ATA
T
H
K
H
I
K
-----
--
--------------
T
LF
SS
R
YW
RRT
A
F
NSVFFV
C
L
--
VIP
W
F
V
IYTW
L
PTI
AQTI
GL
-
-
-
E
D
A
LTA
S
LMLN
A
LL
I
V
GA
-----
L
LG
L
V
LT
H
LLA
H
R
RF
L
L
GS
F
LL
L
TAT
L
V
V
MA
C
L
PS
-
G
SS
--------
L
T
LL
L
F
V
-
L
F
ST
T
I
SA
VS
NL
VG
I
L
P
A
E
S
FPTDIR
SL
GVGF
AT
A
M
SR
L
GA
A
VST
GL
LP
W
------
V
L
A
Q
W
G
-
M
Q
A
T
L
LL
L
A
A
V
L
L
V
G
F
V
V
T
WL
W
APET
K
A
L
P
L
VAA
G
N
fig|364106.7.peg.3117
Escherichia coli UTI89 (9-434/445)
DDLPL
N
RFH
C
RI
AALT
F
G
AH
L
T
DGYVL
GV
IG
Y
A
I
I
QLTPA
MQ
L
TP
F
MA
G
MI
G
GSA
L
L
GLF
L
GSL
VL
G
W
ISD
HI
GR
Q
K
I
F
T
F
S
F
M
L
I
T
L
AS
FLQF
F
A
TT
P
EH
LI
GL
R
I
LIGIG
L
G
G
DY
S
VG
H
T
LL
A
EFSP
R
R
H
RG
VLLGAFS
--------
VV
W
T
VG
YVL
AS
I
A
G
H
HFISESPEA
WRW
L
L
A
SAA
L
P
A
LLI
TLL
RW
GT
--------------------
PESPRWLLR
Q
GR
F
AEA
H
AI
V
H
R
Y
FG
PH
V
LLGD
E
V
ATA
T
H
K
H
I
K
-----
--
--------------
T
LF
SS
R
YW
RRT
A
F
NSVFFV
C
L
--
VIP
W
F
V
IYTW
L
PTI
AQTI
GL
-
-
-
E
D
A
LTA
S
LMLN
A
LL
I
V
GA
-----
L
LG
L
V
LT
H
LLA
H
R
RF
L
L
GS
F
LL
L
TAT
L
V
V
MA
C
L
PS
-
G
SS
--------
L
T
LL
L
F
V
-
L
F
ST
T
I
SA
VS
NL
VG
I
L
P
A
E
S
FPTDIR
SL
GVGF
AT
A
M
SR
L
GA
A
VST
GL
LP
W
------
V
L
A
Q
W
G
-
M
Q
A
T
L
LL
L
A
A
V
L
L
V
G
F
V
V
T
WL
W
APET
K
A
L
P
L
VAA
G
N
fig|364106.8.peg.3117
Escherichia coli UTI89 (9-434/445)
DDLPL
N
RFH
C
RI
AALT
F
G
AH
L
T
DGYVL
GV
IG
Y
A
I
I
QLTPA
MQ
L
TP
F
MA
G
MI
G
GSA
L
L
GLF
L
GSL
VL
G
W
ISD
HI
GR
Q
K
I
F
T
F
S
F
M
L
I
T
L
AS
FLQF
F
A
TT
P
EH
LI
GL
R
I
LIGIG
L
G
G
DY
S
VG
H
T
LL
A
EFSP
R
R
H
RG
VLLGAFS
--------
VV
W
T
VG
YVL
AS
I
A
G
H
HFISESPEA
WRW
L
L
A
SAA
L
P
A
LLI
TLL
RW
GT
--------------------
PESPRWLLR
Q
GR
F
AEA
H
AI
V
H
R
Y
FG
PH
V
LLGD
E
V
ATA
T
H
K
H
I
K
-----
--
--------------
T
LF
SS
R
YW
RRT
A
F
NSVFFV
C
L
--
VIP
W
F
V
IYTW
L
PTI
AQTI
GL
-
-
-
E
D
A
LTA
S
LMLN
A
LL
I
V
GA
-----
L
LG
L
V
LT
H
LLA
H
R
RF
L
L
GS
F
LL
L
TAT
L
V
V
MA
C
L
PS
-
G
SS
--------
L
T
LL
L
F
V
-
L
F
ST
T
I
SA
VS
NL
VG
I
L
P
A
E
S
FPTDIR
SL
GVGF
AT
A
M
SR
L
GA
A
VST
GL
LP
W
------
V
L
A
Q
W
G
-
M
Q
A
T
L
LL
L
A
A
V
L
L
V
G
F
V
V
T
WL
W
APET
K
A
L
P
L
VAA
G
N
fig|216593.1.peg.1224
Escherichia coli E2348/69 (39-465/475)
DDLPL
N
RFH
C
RI
AALT
F
G
AH
L
T
DGYVL
GV
IG
Y
A
I
I
QLTPA
MQ
L
TP
F
MA
G
MI
G
GSA
L
L
GLF
L
GSL
VL
G
W
ISD
HI
GR
Q
K
I
F
T
F
S
F
M
L
I
T
L
AS
FLQF
F
A
TT
P
EH
LI
GL
R
I
LIGIG
L
G
G
DY
S
VG
H
T
LL
A
EFSP
R
R
H
RG
ILLGAFS
--------
VV
W
T
VG
YVL
AS
I
A
G
H
HFISESPEA
WRW
L
L
A
SAA
L
P
A
LLI
TLL
RW
GT
--------------------
PESPRWLLR
Q
GR
F
AEA
H
AI
V
H
R
Y
FG
PH
V
LLGD
E
V
ATA
T
H
K
H
I
K
-----
--
--------------
T
LF
SS
R
YW
RRT
A
F
NSVFFV
C
L
--
VIP
W
F
V
IYTW
L
PTI
AQTI
GL
-
-
-
E
D
A
LTA
S
LMLN
A
LL
I
V
GA
-----
L
LG
L
V
LT
H
LLA
H
R
RF
L
L
GS
F
LL
L
AAT
L
V
V
MA
C
L
PS
-
G
SS
--------
L
T
LL
L
F
V
-
L
F
ST
T
I
SA
VS
NL
VG
I
L
P
A
E
S
FPTDIR
SL
GVGF
AT
A
M
SR
L
GA
A
VST
GL
LP
W
------
V
L
A
Q
W
G
-
M
Q
VT
L
LL
L
A
A
V
L
L
V
G
F
V
V
T
WL
W
APET
K
A
L
P
L
VAA
G
NV
fig|431946.3.peg.2680
Escherichia coli SE15 (9-435/445)
DDLPL
N
RFH
C
RI
AALT
F
G
AH
L
T
DGYVL
GV
IG
Y
A
I
I
QLTPA
MQ
L
TP
F
MA
G
MI
G
GSA
L
L
GLF
L
GSL
VL
G
W
ISD
HI
GR
Q
K
I
F
T
F
S
F
M
L
I
T
L
AS
FLQF
F
A
TT
P
EH
LI
GL
R
I
LIGIG
L
G
G
DY
S
VG
H
T
LL
A
EFSP
R
R
H
RG
ILLGAFS
--------
VV
W
T
VG
YVL
AS
I
A
G
H
HFISESPEA
WRW
L
L
A
SAA
L
P
A
LLI
TLL
RW
GT
--------------------
PESPRWLLR
Q
GR
F
AEA
H
AI
V
H
R
Y
FG
PH
V
LLGD
E
V
ATA
T
H
K
H
I
K
-----
--
--------------
T
LF
SS
R
YW
RRT
A
F
NSVFFV
C
L
--
VIP
W
F
V
IYTW
L
PTI
AQTI
GL
-
-
-
E
D
A
LTA
S
LMLN
A
LL
I
V
GA
-----
L
LG
L
V
LT
H
LLA
H
R
KF
L
L
GS
F
LL
L
AAT
L
V
V
MA
C
L
PS
-
G
SS
--------
L
T
LL
L
F
V
-
L
F
ST
T
I
SA
VS
NL
VG
I
L
P
A
E
S
FPTDIR
SL
GVGF
AT
A
M
SR
L
GA
A
VST
GL
LP
W
------
V
L
A
Q
W
G
-
M
Q
A
T
L
LL
L
A
A
V
L
L
V
G
F
V
V
T
WL
W
APET
K
A
L
P
L
VAA
G
NV
fig|656444.3.peg.3878
Escherichia coli TA280 (9-435/445)
DDLPL
N
RFH
C
RI
AALT
F
G
AH
L
T
DGYVL
GV
IG
Y
A
I
I
QLTPA
MQ
L
TP
F
MA
G
MI
G
GSA
L
L
GLF
I
GSL
VL
G
W
ISD
HI
GR
Q
K
I
F
T
F
S
F
L
L
I
T
L
AS
FLQF
F
A
TT
P
EH
LI
GL
R
I
LIGIG
L
G
G
DY
S
VG
H
T
LL
A
EFSP
R
R
H
RG
VLLGAFS
--------
VV
W
T
VG
YVL
AS
I
A
G
H
HFISESPEA
WRW
L
L
A
SAA
L
P
A
LLI
TLL
RW
GT
--------------------
PESPRWLLR
Q
GR
F
AEA
H
AI
V
H
R
Y
FG
PH
V
LLGD
E
V
ATA
T
H
K
H
I
K
-----
--
--------------
T
LF
SS
R
YW
RRT
A
F
NSVFFV
C
L
--
VIP
W
F
V
IYTW
L
PTI
TQTI
GL
-
-
-
E
D
A
LTA
S
LMLN
A
LL
I
V
GA
-----
L
LG
L
V
LT
H
LLA
H
R
KF
L
L
GS
F
LL
L
AAT
L
V
V
MA
C
L
PS
-
G
SS
--------
L
T
LL
L
F
V
-
L
F
ST
T
I
SA
VS
NL
VG
I
L
P
A
E
S
FPTDIR
SL
GVGF
AT
A
M
SR
L
GA
A
VST
GL
LP
W
------
V
L
A
Q
W
G
-
M
Q
VT
L
I
L
L
A
A
V
L
L
V
G
F
V
V
T
WL
W
APET
K
A
L
P
L
VAA
G
NV
fig|216592.1.peg.3551
Escherichia coli 042 (34-460/470)
DDLPL
N
S
FH
C
RI
AALT
F
G
AH
L
T
DGYVL
GV
IG
Y
A
I
I
QLTPA
MQ
L
TP
F
MA
G
MI
G
GSA
L
L
GLF
L
GSL
VL
G
W
ISD
HI
GR
Q
K
I
F
T
F
S
F
V
L
I
T
L
AS
FLQF
F
A
TT
P
EH
LI
GL
R
I
LIGIG
L
G
G
DY
S
VG
H
T
LL
A
EFSP
R
R
H
RG
ILLGAFS
--------
VV
W
T
VG
YVL
AS
I
A
G
H
HFISESPEA
WRW
L
L
A
SAA
L
P
A
LLI
TLL
RW
GT
--------------------
PESPRWLLR
Q
GR
F
AEA
H
AI
V
H
R
Y
L
G
PH
V
LLGD
E
V
ATA
T
H
K
H
I
K
-----
--
--------------
T
LF
SS
R
YW
RRT
V
F
NSVFFV
C
L
--
VIP
W
F
V
IYTW
L
PTI
AQTI
GL
-
-
-
E
D
A
LTA
S
LMLN
A
LL
I
V
GA
-----
L
LG
L
V
LT
H
LLA
H
R
KF
L
L
GS
F
LL
L
AAT
L
V
V
MA
C
L
PS
-
G
SS
--------
L
T
LL
L
F
V
-
L
F
ST
T
I
SA
VS
NL
VG
I
L
P
A
E
S
FPTDIR
SL
GVGF
AT
A
M
SR
L
GA
A
VST
GL
LP
W
------
V
L
A
Q
W
G
-
M
Q
A
T
L
LL
L
A
A
V
L
L
I
G
F
V
V
T
WL
W
APET
K
A
L
P
L
VAA
G
NV
fig|340197.3.peg.1305
Escherichia coli F11 (33-458/469)
DDLPL
N
RFH
C
RI
AALT
F
G
AH
L
T
DGYVL
GV
IG
Y
A
I
I
QLTPA
MQ
L
TP
F
MA
G
MI
G
GSA
L
L
GLF
L
GSL
VL
G
W
ISD
HI
GR
Q
K
I
F
T
F
S
F
M
L
I
T
L
AS
FLQF
F
A
TT
P
EH
LI
GL
R
I
LIGIG
L
G
G
DY
S
VG
H
T
LL
A
EFSP
R
R
H
RG
ILLGAFS
--------
VV
W
T
VG
YVL
AS
I
A
G
H
HFISESPEA
WRW
L
L
A
SAA
L
P
A
LLI
TLL
RW
GT
--------------------
PESPRWLLR
Q
GR
F
AEA
H
AI
V
H
R
Y
FG
PH
V
LLGD
E
V
ATA
T
H
K
H
I
K
-----
--
--------------
T
LF
SS
R
YW
RRT
A
F
NSVFFV
C
L
--
VIP
W
F
V
IYTW
L
PTI
AQTI
GL
-
-
-
E
D
A
LTA
S
LMLN
A
LL
I
V
GA
-----
L
LG
L
V
LT
H
LLA
H
R
KF
L
L
GS
F
LL
L
AAT
L
V
V
MA
C
L
PS
-
G
SS
--------
L
T
LL
L
F
V
-
L
F
ST
T
I
SA
VS
NL
VG
I
L
P
A
E
S
FPTDIR
SL
GVGF
AT
A
M
SR
L
GA
A
VST
GL
LP
W
------
V
L
A
Q
W
G
-
M
Q
VT
L
LL
L
A
A
V
L
L
V
G
F
V
V
T
WL
W
APET
K
A
L
P
L
VAA
G
N
fig|656379.3.peg.4134
Escherichia coli FVEC1302 (9-435/445)
DDLPL
N
RFH
C
RI
AALT
F
G
AH
L
T
DGYVL
GV
IG
Y
A
I
I
QLTPA
MQ
L
TP
F
MA
G
MI
G
GSA
L
L
GLF
L
GSL
VL
G
W
ISD
HI
GR
Q
K
I
F
T
F
S
F
L
L
I
T
L
AS
FLQF
F
A
TT
P
EH
LI
GL
R
I
LIGIG
L
G
G
DY
S
VG
H
T
LL
A
EFSP
R
R
H
RG
ILLGAFS
--------
VV
W
T
VG
YVL
AS
I
A
G
H
HFISESPEA
WRW
L
L
A
SAA
L
P
A
LLI
TLL
RW
GT
--------------------
PESPRWLLR
Q
GR
F
AEA
H
AI
V
H
R
Y
FG
PH
V
LLGD
E
V
ATA
T
H
K
H
I
K
-----
--
--------------
T
LF
SS
R
YW
RRT
A
F
NSVFFV
C
L
--
VIP
W
F
V
IYTW
L
PTI
AQTI
GL
-
-
-
E
D
A
LTA
S
LMLN
A
LL
I
V
GA
-----
L
LG
L
V
LT
H
LLA
H
R
KF
L
L
GS
F
LL
L
AAT
L
V
V
MA
C
L
PS
-
G
SS
--------
L
T
LL
L
F
V
-
L
F
ST
T
I
SA
VS
NL
VG
I
L
P
A
E
S
FPTDIR
SL
GVGF
AT
A
M
SR
L
GA
A
VST
GL
LP
W
------
V
L
A
Q
W
G
-
M
Q
VT
L
LL
L
A
A
V
L
L
V
G
F
V
V
T
WL
W
APET
K
A
L
P
L
VAA
G
NV
fig|656419.3.peg.3592
Escherichia coli M718 (9-435/445)
DDLPL
N
RFH
C
RI
AALT
F
G
AH
L
T
DGYVL
GV
IG
Y
A
I
I
QLTPA
MQ
L
TP
F
MA
G
MI
G
GSA
L
L
GLF
L
GSL
VL
G
W
ISD
HI
GR
Q
K
I
F
T
F
S
F
L
L
I
T
L
AS
FLQF
F
A
TT
P
EH
LI
GL
R
I
LIGIG
L
G
G
DY
S
VG
H
T
LL
A
EFSP
R
R
H
RG
ILLGAFS
--------
VV
W
T
VG
YVL
AS
I
A
G
H
HFISESPEA
WRW
L
L
A
SAA
L
P
A
LLI
TLL
RW
GT
--------------------
PESPRWLLR
Q
GR
F
AEA
H
AI
V
H
R
Y
FG
PH
V
LLGD
E
V
ATA
T
H
K
H
I
K
-----
--
--------------
T
LF
SS
R
YW
RRT
A
F
NSVFFV
C
L
--
VIP
W
F
V
IYTW
L
PTI
AQTI
GL
-
-
-
E
D
A
LTA
S
LMLN
A
LL
I
V
GA
-----
L
LG
L
V
LT
H
LLA
H
R
KF
L
L
GS
F
LL
L
AAT
L
V
V
MA
C
L
PS
-
G
SS
--------
L
T
LL
L
F
V
-
L
F
ST
T
I
SA
VS
NL
VG
I
L
P
A
E
S
FPTDIR
SL
GVGF
AT
A
M
SR
L
GA
A
VST
GL
LP
W
------
V
L
A
Q
W
G
-
M
Q
VT
L
LL
L
A
A
V
L
L
V
G
F
V
V
T
WL
W
APET
K
A
L
P
L
VAA
G
NV
fig|749549.3.peg.4736
Escherichia coli MS 198-1 (9-435/445)
DDLPL
N
RFH
C
RI
AALT
F
G
AH
L
T
DGYVL
GV
IG
Y
A
I
I
QLTPA
MQ
L
TP
F
MA
G
MI
G
GSA
L
L
GLF
L
GSL
VL
G
W
ISD
HI
GR
Q
K
I
F
T
F
S
F
L
L
I
T
L
AS
FLQF
F
A
TT
P
EH
LI
GL
R
I
LIGIG
L
G
G
DY
S
VG
H
T
LL
A
EFSP
R
R
H
RG
ILLGAFS
--------
VV
W
T
VG
YVL
AS
I
A
G
H
HFISESPEA
WRW
L
L
A
SAA
L
P
A
LLI
TLL
RW
GT
--------------------
PESPRWLLR
Q
GR
F
AEA
H
AI
V
H
R
Y
FG
PH
V
LLGD
E
V
ATA
T
H
K
H
I
K
-----
--
--------------
T
LF
SS
R
YW
RRT
A
F
NSVFFV
C
L
--
VIP
W
F
V
IYTW
L
PTI
AQTI
GL
-
-
-
E
D
A
LTA
S
LMLN
A
LL
I
V
GA
-----
L
LG
L
V
LT
H
LLA
H
R
KF
L
L
GS
F
LL
L
AAT
L
V
V
MA
C
L
PS
-
G
SS
--------
L
T
LL
L
F
V
-
L
F
ST
T
I
SA
VS
NL
VG
I
L
P
A
E
S
FPTDIR
SL
GVGF
AT
A
M
SR
L
GA
A
VST
GL
LP
W
------
V
L
A
Q
W
G
-
M
Q
VT
L
LL
L
A
A
V
L
L
V
G
F
V
V
T
WL
W
APET
K
A
L
P
L
VAA
G
NV
fig|656437.3.peg.3099
Escherichia coli TA143 (9-435/445)
DDLPL
N
RFH
C
RI
AALT
F
G
AH
L
T
DGYVL
GV
IG
Y
A
I
I
QLTPA
MQ
L
TP
F
MA
G
MI
G
GSA
L
L
GLF
L
GSL
VL
G
W
ISD
HI
GR
Q
K
I
F
T
F
S
F
L
L
I
T
L
AS
FLQF
F
A
TT
P
EH
LI
GL
R
I
LIGIG
L
G
G
DY
S
VG
H
T
LL
A
EFSP
R
R
H
RG
ILLGAFS
--------
VV
W
T
VG
YVL
AS
I
A
G
H
HFISESPEA
WRW
L
L
A
SAA
L
P
A
LLI
TLL
RW
GT
--------------------
PESPRWLLR
Q
GR
F
AEA
H
AI
V
H
R
Y
FG
PH
V
LLGD
E
V
ATA
T
H
K
H
I
K
-----
--
--------------
T
LF
SS
R
YW
RRT
A
F
NSVFFV
C
L
--
VIP
W
F
V
IYTW
L
PTI
AQTI
GL
-
-
-
E
D
A
LTA
S
LMLN
A
LL
I
V
GA
-----
L
LG
L
V
LT
H
LLA
H
R
KF
L
L
GS
F
LL
L
AAT
L
V
V
MA
C
L
PS
-
G
SS
--------
L
T
LL
L
F
V
-
L
F
ST
T
I
SA
VS
NL
VG
I
L
P
A
E
S
FPTDIR
SL
GVGF
AT
A
M
SR
L
GA
A
VST
GL
LP
W
------
V
L
A
Q
W
G
-
M
Q
VT
L
LL
L
A
A
V
L
L
V
G
F
V
V
T
WL
W
APET
K
A
L
P
L
VAA
G
NV
fig|753642.3.peg.386
Escherichia coli NC101 (9-435/445)
DDLPL
N
RFH
C
RI
AALT
F
G
AH
L
T
DGYVL
GV
IG
Y
A
I
I
QLTPA
MQ
L
TP
F
MA
G
MI
G
GSA
L
L
GLF
L
GSL
VL
G
W
ISD
HI
GR
Q
K
I
F
T
F
S
F
M
L
I
T
L
AS
FLQF
F
A
TT
P
EH
LI
GL
R
I
LIGIG
L
G
G
DY
S
VG
H
T
LL
A
EFSP
R
R
H
RG
ILLGAFS
--------
VV
W
T
VG
YVL
AS
I
A
G
H
HFISESPEA
WRW
L
L
A
SAA
L
P
A
LLI
TLL
RW
GT
--------------------
PESPRWLLR
Q
GR
F
AEA
H
AI
V
H
R
Y
FG
PH
V
LLGD
E
V
ATA
T
H
K
H
I
K
-----
--
--------------
T
LF
SS
R
YW
RRT
A
F
NSVFFV
C
L
--
VIP
W
F
V
IYTW
L
PTI
AQTI
GL
-
-
-
E
D
A
LTA
S
LMLN
A
LL
I
V
GA
-----
L
LG
L
V
LT
H
LLA
H
R
RF
L
L
GS
F
LL
L
AAT
L
V
V
MA
C
L
PS
-
G
SS
--------
L
T
LL
L
F
V
-
L
F
ST
T
I
SA
VS
NL
VG
I
L
P
A
E
S
FPTDIR
SL
GVGF
AT
A
M
SR
L
GA
A
VST
GL
LP
W
------
V
L
A
Q
W
G
-
M
Q
A
T
L
LL
L
A
A
V
L
L
V
G
F
V
V
T
WL
W
APET
K
A
L
P
L
VAA
G
NV
fig|562.376.peg.3581
Escherichia coli WV_060327 (9-435/445)
DDLPL
N
RFH
C
RI
AALT
F
G
AH
L
T
DGYVL
GV
IG
Y
A
I
I
QLTPA
MQ
L
TP
F
MA
G
MI
G
GSA
L
L
GLF
L
GSL
VL
G
W
ISD
HI
GR
Q
K
I
F
T
F
S
F
M
L
I
T
L
AS
FLQF
F
A
TT
P
EH
LI
GL
R
I
LIGIG
L
G
G
DY
S
VG
H
T
LL
A
EFSP
R
R
H
RG
ILLGAFS
--------
VV
W
T
VG
YVL
AS
I
A
G
H
HFISESPEA
WRW
L
L
A
SAA
L
P
A
LLI
TLL
RW
GT
--------------------
PESPRWLLR
Q
GR
F
AEA
H
AI
V
H
R
Y
FG
PH
V
LLGD
E
V
ATA
T
H
K
H
I
K
-----
--
--------------
T
LF
SS
R
YW
RRT
A
F
NSVFFV
C
L
--
VIP
W
F
V
IYTW
L
PTI
AQTI
GL
-
-
-
E
D
A
LTA
S
LMLN
A
LL
I
V
GA
-----
L
LG
L
V
LT
H
LLA
H
R
RF
L
L
GS
F
LL
L
AAT
L
V
V
MA
C
L
PS
-
G
SS
--------
L
T
LL
L
F
V
-
L
F
ST
T
I
SA
VS
NL
VG
I
L
P
A
E
S
FPTDIR
SL
GVGF
AT
A
M
SR
L
GA
A
VST
GL
LP
W
------
V
L
A
Q
W
G
-
M
Q
A
T
L
LL
L
A
A
V
L
L
V
G
F
V
V
T
WL
W
APET
K
A
L
P
L
VAA
G
NV
fig|216592.3.peg.3100
Escherichia coli 042 (9-435/445)
DDLPL
N
S
FH
C
RI
AALT
F
G
AH
L
T
DGYVL
GV
IG
Y
A
I
I
QLTPA
MQ
L
TP
F
MA
G
MI
G
GSA
L
L
GLF
L
GSL
VL
G
W
ISD
HI
GR
Q
K
I
F
T
F
S
F
V
L
I
T
L
AS
FLQF
F
A
TT
P
EH
LI
GL
R
I
LIGIG
L
G
G
DY
S
VG
H
T
LL
A
EFSP
R
R
H
RG
ILLGAFS
--------
VV
W
T
VG
YVL
AS
I
A
G
H
HFISESPEA
WRW
L
L
A
SAA
L
P
A
LLI
TLL
RW
GT
--------------------
PESPRWLLR
Q
GR
F
AEA
H
AI
V
H
R
Y
L
G
PH
V
LLGD
E
V
ATA
T
H
K
H
I
K
-----
--
--------------
T
LF
SS
R
YW
RRT
V
F
NSVFFV
C
L
--
VIP
W
F
V
IYTW
L
PTI
AQTI
GL
-
-
-
E
D
A
LTA
S
LMLN
A
LL
I
V
GA
-----
L
LG
L
V
LT
H
LLA
H
R
KF
L
L
GS
F
LL
L
AAT
L
V
V
MA
C
L
PS
-
G
SS
--------
L
T
LL
L
F
V
-
L
F
ST
T
I
SA
VS
NL
VG
I
L
P
A
E
S
FPTDIR
SL
GVGF
AT
A
M
SR
L
GA
A
VST
GL
LP
W
------
V
L
A
Q
W
G
-
M
Q
A
T
L
LL
L
A
A
V
L
L
I
G
F
V
V
T
WL
W
APET
K
A
L
P
L
VAA
G
NV
fig|656380.3.peg.4051
Escherichia coli FVEC1412 (2-428/438)
DDLPL
N
RFH
C
RI
AALT
F
G
AH
L
T
DGYVL
GV
IG
Y
A
I
I
QLTPA
MQ
L
TP
F
MA
G
MI
G
GSA
L
L
GLF
L
GSL
VL
G
W
ISD
HI
GR
Q
K
I
F
T
F
S
F
L
L
I
T
L
AS
FLQF
F
A
TT
P
EH
LI
GL
R
I
LIGIG
L
G
G
DY
S
VG
H
T
LL
A
EFSP
R
R
H
RG
ILLGAFS
--------
VV
W
T
VG
YVL
AS
I
A
G
H
HFISESPEA
WRW
L
L
A
SAA
L
P
A
LLI
TLL
RW
GT
--------------------
PESPRWLLR
Q
GR
F
AEA
H
AI
V
H
R
Y
FG
PH
V
LLGD
E
V
ATA
T
H
K
H
I
K
-----
--
--------------
T
LF
SS
R
YW
RRT
A
F
NSVFFV
C
L
--
VIP
W
F
V
IYTW
L
PTI
AQTI
GL
-
-
-
E
D
A
LTA
S
LMLN
A
LL
I
V
GA
-----
L
LG
L
V
LT
H
LLA
H
R
KF
L
L
GS
F
LL
L
AAT
L
V
V
MA
C
L
PS
-
G
SS
--------
L
T
LL
L
F
V
-
L
F
ST
T
I
SA
VS
NL
VG
I
L
P
A
E
S
FPTDIR
SL
GVGF
AT
A
M
SR
L
GA
A
VST
GL
LP
W
------
V
L
A
Q
W
G
-
M
Q
VT
L
LL
L
A
A
V
L
L
V
G
F
V
V
T
WL
W
APET
K
A
L
P
L
VAA
G
NV
fig|585056.7.peg.3276
Escherichia coli UMN026 (2-428/438)
DDLPL
N
RFH
C
RI
AALT
F
G
AH
L
T
DGYVL
GV
IG
Y
A
I
I
QLTPA
MQ
L
TP
F
MA
G
MI
G
GSA
L
L
GLF
L
GSL
VL
G
W
ISD
HI
GR
Q
K
I
F
T
F
S
F
L
L
I
T
L
AS
FLQF
F
A
TT
P
EH
LI
GL
R
I
LIGIG
L
G
G
DY
S
VG
H
T
LL
A
EFSP
R
R
H
RG
ILLGAFS
--------
VV
W
T
VG
YVL
AS
I
A
G
H
HFISESPEA
WRW
L
L
A
SAA
L
P
A
LLI
TLL
RW
GT
--------------------
PESPRWLLR
Q
GR
F
AEA
H
AI
V
H
R
Y
FG
PH
V
LLGD
E
V
ATA
T
H
K
H
I
K
-----
--
--------------
T
LF
SS
R
YW
RRT
A
F
NSVFFV
C
L
--
VIP
W
F
V
IYTW
L
PTI
AQTI
GL
-
-
-
E
D
A
LTA
S
LMLN
A
LL
I
V
GA
-----
L
LG
L
V
LT
H
LLA
H
R
KF
L
L
GS
F
LL
L
AAT
L
V
V
MA
C
L
PS
-
G
SS
--------
L
T
LL
L
F
V
-
L
F
ST
T
I
SA
VS
NL
VG
I
L
P
A
E
S
FPTDIR
SL
GVGF
AT
A
M
SR
L
GA
A
VST
GL
LP
W
------
V
L
A
Q
W
G
-
M
Q
VT
L
LL
L
A
A
V
L
L
V
G
F
V
V
T
WL
W
APET
K
A
L
P
L
VAA
G
NV
fig|670897.3.peg.691
Escherichia coli 2362-75 (33-459/469)
DDLPL
N
RFH
C
RI
AALT
F
G
AH
L
T
DGYVL
GV
IG
Y
A
I
I
QLTPA
MQ
L
TP
F
MA
G
MI
G
GSA
L
L
GLF
L
GSL
VL
G
W
ISD
HI
GR
Q
K
I
F
T
F
S
F
M
L
I
T
L
AS
FLQF
F
A
TT
P
EH
LI
GL
R
I
LIGIG
L
G
G
DY
S
VG
H
T
LL
A
EFSP
R
R
H
RG
ILLGAFS
--------
VV
W
T
VG
YVL
AS
I
A
G
H
HFISESPEA
WRW
L
L
A
SAA
L
P
A
LLI
TLL
RW
GT
--------------------
PESPRWLLR
Q
GR
F
AEA
H
AI
V
H
R
Y
FG
PH
V
LLGD
E
V
ATA
T
H
K
H
I
K
-----
--
--------------
T
LF
SS
R
YW
RRT
A
F
NSVFFV
C
L
--
VIP
W
F
V
IYTW
L
PTI
AQTI
GL
-
-
-
E
D
A
LTA
S
LMLN
A
LL
I
V
GA
-----
L
LG
L
V
LT
H
LLA
H
R
RF
L
L
GS
F
LL
L
AAT
L
V
V
MA
C
L
PS
-
G
SS
--------
L
T
LL
L
F
V
-
L
F
ST
T
I
SA
VS
NL
VG
I
L
P
A
E
S
FPTDIR
SL
GVGF
AT
A
M
SR
L
GA
A
VST
GL
LP
W
------
V
L
A
Q
W
G
-
M
Q
VT
L
LL
L
A
A
V
L
L
V
G
F
V
V
T
WL
W
APET
K
A
L
P
L
VAA
G
NV
fig|749531.3.peg.5040
Escherichia coli MS 69-1 (9-435/445)
DDLPL
N
RFH
C
RI
AALT
F
G
AH
L
T
DGYVL
GV
IG
Y
A
I
I
QLTPA
MQ
L
TP
L
MA
G
MI
G
GSA
L
L
GLF
L
GSL
VL
G
W
ISD
HI
GR
Q
K
I
F
T
F
S
F
L
L
I
T
L
AS
FLQY
F
A
TT
P
EH
LI
GL
R
I
LIGIG
L
G
G
DY
S
VG
H
T
LL
A
EFSP
R
R
H
RG
VLLGAFS
--------
VV
W
T
VG
YVL
AS
I
A
G
H
HFITESPEA
WRW
L
L
A
SAA
L
P
A
LLI
TLL
RW
GT
--------------------
PESPRWLLR
Q
GR
F
AEA
H
AI
V
H
R
Y
FG
PH
V
LLGD
E
V
ATA
T
H
K
H
I
K
-----
--
--------------
T
LF
SS
R
YW
RRT
A
F
NSVFFV
C
L
--
VIP
W
F
V
IYTW
L
PTI
AQTI
GL
-
-
-
E
D
A
LTA
S
LMLN
A
LL
I
V
GA
-----
L
LG
L
V
LT
H
LLA
H
R
KF
L
L
GS
F
LL
L
AAT
L
V
V
MA
C
L
PS
-
G
SS
--------
L
T
LL
L
F
V
-
L
F
ST
T
I
SA
VS
NL
VG
I
L
P
A
E
S
FPTDIR
SL
GVGF
AT
A
M
SR
L
GA
A
VST
GL
LP
W
------
V
L
A
Q
W
G
-
M
Q
VT
L
LL
L
A
A
V
L
L
V
G
F
V
V
T
WL
W
APET
K
A
L
P
L
VAA
G
NV
fig|574521.7.peg.3081
Escherichia coli O127:H6 str. E2348/69 (33-459/469)
DDLPL
N
RFH
C
RI
AALT
F
G
AH
L
T
DGYVL
GV
IG
Y
A
I
I
QLTPA
MQ
L
TP
F
MA
G
MI
G
GSA
L
L
GLF
L
GSL
VL
G
W
ISD
HI
GR
Q
K
I
F
T
F
S
F
M
L
I
T
L
AS
FLQF
F
A
TT
P
EH
LI
GL
R
I
LIGIG
L
G
G
DY
S
VG
H
T
LL
A
EFSP
R
R
H
RG
ILLGAFS
--------
VV
W
T
VG
YVL
AS
I
A
G
H
HFISESPEA
WRW
L
L
A
SAA
L
P
A
LLI
TLL
RW
GT
--------------------
PESPRWLLR
Q
GR
F
AEA
H
AI
V
H
R
Y
FG
PH
V
LLGD
E
V
ATA
T
H
K
H
I
K
-----
--
--------------
T
LF
SS
R
YW
RRT
A
F
NSVFFV
C
L
--
VIP
W
F
V
IYTW
L
PTI
AQTI
GL
-
-
-
E
D
A
LTA
S
LMLN
A
LL
I
V
GA
-----
L
LG
L
V
LT
H
LLA
H
R
RF
L
L
GS
F
LL
L
AAT
L
V
V
MA
C
L
PS
-
G
SS
--------
L
T
LL
L
F
V
-
L
F
ST
T
I
SA
VS
NL
VG
I
L
P
A
E
S
FPTDIR
SL
GVGF
AT
A
M
SR
L
GA
A
VST
GL
LP
W
------
V
L
A
Q
W
G
-
M
Q
VT
L
LL
L
A
A
V
L
L
V
G
F
V
V
T
WL
W
APET
K
A
L
P
L
VAA
G
NV
fig|362663.8.peg.2779
Escherichia coli 536 (9-434/445)
DDLPL
N
RFH
C
RI
AALT
F
G
AH
L
T
DGYVL
GV
IG
Y
A
I
I
QLTPA
MQ
L
TP
F
MA
G
MI
G
GSA
L
L
GLF
L
GSL
VL
G
W
ISD
HI
GR
Q
K
I
F
T
F
S
F
M
L
I
T
L
AS
FLQF
F
A
TT
P
EH
LI
GL
R
I
LIGIG
L
G
G
DY
S
VG
H
T
LL
A
EFSP
R
R
H
RG
ILLGAFS
--------
VV
W
T
VG
YVL
AS
I
A
G
H
HFISESPEA
WRW
L
L
A
SAA
L
P
A
LLI
TLL
RW
GT
--------------------
PESPRWLLR
Q
GR
F
AEA
H
AI
V
H
R
Y
FG
PH
V
LLGD
E
V
ATA
T
H
K
H
I
K
-----
--
--------------
T
LF
SS
R
YW
RRT
A
F
NSVFFV
C
L
--
VIP
W
F
V
IYTW
L
PTI
AQTI
GL
-
-
-
E
D
A
LTA
S
LMLN
A
LL
I
V
GA
-----
L
LG
L
V
LT
H
LLA
H
R
KF
L
L
GS
F
LL
L
AAT
L
V
V
MA
C
L
PS
-
G
SS
--------
L
T
LL
L
F
V
-
L
F
ST
T
I
SA
VS
NL
VG
I
L
P
A
E
S
FPTDIR
SL
GVGF
AT
A
M
SR
L
GA
A
VST
GL
LP
W
------
V
L
A
Q
W
G
-
M
Q
VT
L
LL
L
A
A
V
L
L
V
G
F
V
V
T
WL
W
APET
K
A
L
P
L
VAA
G
N
fig|362663.9.peg.2785
Escherichia coli 536 (9-434/445)
DDLPL
N
RFH
C
RI
AALT
F
G
AH
L
T
DGYVL
GV
IG
Y
A
I
I
QLTPA
MQ
L
TP
F
MA
G
MI
G
GSA
L
L
GLF
L
GSL
VL
G
W
ISD
HI
GR
Q
K
I
F
T
F
S
F
M
L
I
T
L
AS
FLQF
F
A
TT
P
EH
LI
GL
R
I
LIGIG
L
G
G
DY
S
VG
H
T
LL
A
EFSP
R
R
H
RG
ILLGAFS
--------
VV
W
T
VG
YVL
AS
I
A
G
H
HFISESPEA
WRW
L
L
A
SAA
L
P
A
LLI
TLL
RW
GT
--------------------
PESPRWLLR
Q
GR
F
AEA
H
AI
V
H
R
Y
FG
PH
V
LLGD
E
V
ATA
T
H
K
H
I
K
-----
--
--------------
T
LF
SS
R
YW
RRT
A
F
NSVFFV
C
L
--
VIP
W
F
V
IYTW
L
PTI
AQTI
GL
-
-
-
E
D
A
LTA
S
LMLN
A
LL
I
V
GA
-----
L
LG
L
V
LT
H
LLA
H
R
KF
L
L
GS
F
LL
L
AAT
L
V
V
MA
C
L
PS
-
G
SS
--------
L
T
LL
L
F
V
-
L
F
ST
T
I
SA
VS
NL
VG
I
L
P
A
E
S
FPTDIR
SL
GVGF
AT
A
M
SR
L
GA
A
VST
GL
LP
W
------
V
L
A
Q
W
G
-
M
Q
VT
L
LL
L
A
A
V
L
L
V
G
F
V
V
T
WL
W
APET
K
A
L
P
L
VAA
G
N
fig|340197.5.peg.1371
Escherichia coli F11 (9-434/445)
DDLPL
N
RFH
C
RI
AALT
F
G
AH
L
T
DGYVL
GV
IG
Y
A
I
I
QLTPA
MQ
L
TP
F
MA
G
MI
G
GSA
L
L
GLF
L
GSL
VL
G
W
ISD
HI
GR
Q
K
I
F
T
F
S
F
M
L
I
T
L
AS
FLQF
F
A
TT
P
EH
LI
GL
R
I
LIGIG
L
G
G
DY
S
VG
H
T
LL
A
EFSP
R
R
H
RG
ILLGAFS
--------
VV
W
T
VG
YVL
AS
I
A
G
H
HFISESPEA
WRW
L
L
A
SAA
L
P
A
LLI
TLL
RW
GT
--------------------
PESPRWLLR
Q
GR
F
AEA
H
AI
V
H
R
Y
FG
PH
V
LLGD
E
V
ATA
T
H
K
H
I
K
-----
--
--------------
T
LF
SS
R
YW
RRT
A
F
NSVFFV
C
L
--
VIP
W
F
V
IYTW
L
PTI
AQTI
GL
-
-
-
E
D
A
LTA
S
LMLN
A
LL
I
V
GA
-----
L
LG
L
V
LT
H
LLA
H
R
KF
L
L
GS
F
LL
L
AAT
L
V
V
MA
C
L
PS
-
G
SS
--------
L
T
LL
L
F
V
-
L
F
ST
T
I
SA
VS
NL
VG
I
L
P
A
E
S
FPTDIR
SL
GVGF
AT
A
M
SR
L
GA
A
VST
GL
LP
W
------
V
L
A
Q
W
G
-
M
Q
VT
L
LL
L
A
A
V
L
L
V
G
F
V
V
T
WL
W
APET
K
A
L
P
L
VAA
G
N
fig|749550.3.peg.723
Escherichia coli MS 200-1 (9-434/445)
DDLPL
N
RFH
C
RI
AALT
F
G
AH
L
T
DGYVL
GV
IG
Y
A
I
I
QLTPA
MQ
L
TP
F
MA
G
MI
G
GSA
L
L
GLF
L
GSL
VL
G
W
ISD
HI
GR
Q
K
I
F
T
F
S
F
M
L
I
T
L
AS
FLQF
F
A
TT
P
EH
LI
GL
R
I
LIGIG
L
G
G
DY
S
VG
H
T
LL
A
EFSP
R
R
H
RG
ILLGAFS
--------
VV
W
T
VG
YVL
AS
I
A
G
H
HFISESPEA
WRW
L
L
A
SAA
L
P
A
LLI
TLL
RW
GT
--------------------
PESPRWLLR
Q
GR
F
AEA
H
AI
V
H
R
Y
FG
PH
V
LLGD
E
V
ATA
T
H
K
H
I
K
-----
--
--------------
T
LF
SS
R
YW
RRT
A
F
NSVFFV
C
L
--
VIP
W
F
V
IYTW
L
PTI
AQTI
GL
-
-
-
E
D
A
LTA
S
LMLN
A
LL
I
V
GA
-----
L
LG
L
V
LT
H
LLA
H
R
KF
L
L
GS
F
LL
L
AAT
L
V
V
MA
C
L
PS
-
G
SS
--------
L
T
LL
L
F
V
-
L
F
ST
T
I
SA
VS
NL
VG
I
L
P
A
E
S
FPTDIR
SL
GVGF
AT
A
M
SR
L
GA
A
VST
GL
LP
W
------
V
L
A
Q
W
G
-
M
Q
VT
L
LL
L
A
A
V
L
L
V
G
F
V
V
T
WL
W
APET
K
A
L
P
L
VAA
G
N
fig|550676.3.peg.2697
Escherichia coli B185 (33-459/469)
DDLPL
N
RFH
C
RI
AALT
F
G
AH
L
T
DGYVL
GV
IG
Y
A
I
I
QLTPA
MQ
L
TP
F
MA
G
MI
G
GSA
L
L
GLF
L
GSL
VL
G
W
ISD
HI
GR
Q
K
I
F
T
F
S
F
L
L
I
T
L
AS
FLQF
F
A
TT
P
EH
LI
GL
R
I
LIGIG
L
G
G
DY
S
VG
H
T
LL
A
EFSP
R
R
H
RG
ILLGAFS
--------
VV
W
T
VG
YVL
AS
I
A
G
H
HFISENPEA
WRW
L
L
A
SAA
L
P
A
LLI
TLL
RW
GT
--------------------
PESPRWLLR
Q
GR
F
AEA
H
AI
V
H
R
Y
FG
PH
V
LLGD
E
V
VTA
T
H
K
H
I
K
-----
--
--------------
T
LF
SS
R
YW
RRT
A
F
NSVFFV
C
L
--
VIP
W
F
V
IYTW
L
PTI
AQTI
GL
-
-
-
E
D
A
LTA
S
LMLN
A
LL
I
V
GA
-----
L
LG
L
V
LT
H
LLA
H
R
KF
L
L
GS
F
LL
L
AAT
L
V
V
MA
C
L
PS
-
G
SS
--------
L
T
LL
L
F
V
-
L
F
ST
T
I
SA
VS
NL
VG
I
L
P
A
E
S
FPTDIR
SL
GVGF
AT
A
M
SR
L
GA
A
VST
GL
LP
W
------
V
L
A
Q
W
G
-
M
Q
VT
L
LL
L
A
A
V
L
L
V
G
F
V
V
T
WL
W
APET
K
A
L
P
L
VAA
G
NV
fig|656440.3.peg.2788
Escherichia coli TA206 (9-435/445)
DDLPL
N
RFH
C
RI
AALT
F
G
AH
L
T
DGYVL
GV
IG
Y
A
I
I
QLTPA
MQ
L
TP
F
IA
G
MI
G
GSA
L
L
GLF
L
GSL
VL
G
W
ISD
HI
GR
Q
K
I
F
T
F
S
F
M
L
I
T
L
AS
FLQF
F
A
TT
P
EH
LI
GL
R
I
LIGIG
L
G
G
DY
S
VG
H
T
LL
A
EFSP
R
R
H
RG
ILLGAFS
--------
VV
W
T
VG
YVL
AS
I
A
G
H
HFISESPEA
WRW
L
L
A
SAA
L
P
A
LLI
TLL
RW
GT
--------------------
PESPRWLLR
Q
GR
F
AEA
H
AI
V
H
R
Y
FG
PH
V
LLGD
E
V
ATA
T
H
K
H
I
K
-----
--
--------------
T
LF
SS
R
YW
RRT
A
F
NSVFFV
C
L
--
VIP
W
F
V
IYTW
L
PTI
AQTI
GL
-
-
-
E
D
A
LTA
S
LMLN
A
LL
I
V
GA
-----
L
LG
L
V
LT
H
LLA
H
R
RF
L
L
GS
F
LL
L
AAT
L
V
V
MA
C
L
PS
-
G
SS
--------
L
T
LL
L
F
V
-
L
F
ST
T
I
SA
VS
NL
VG
I
L
P
A
E
S
FPTDIR
SL
GVGF
AT
A
M
SR
L
GA
A
VST
GL
LP
W
------
V
L
A
Q
W
G
-
M
Q
A
T
L
LL
L
A
A
V
L
L
V
G
F
V
V
T
WL
W
APET
K
A
L
P
L
VAA
G
NV
fig|344601.3.peg.2232
Escherichia coli B171 (33-459/469)
DDLPL
N
RFH
C
RI
AALT
F
G
AH
L
T
DGYVL
GV
IG
Y
A
I
I
QLTPA
MQ
L
TP
F
MA
G
MI
G
GSA
L
L
GLF
L
GSL
VL
G
W
ISD
HI
GR
Q
K
I
F
T
F
S
F
L
L
I
T
L
AS
FLQF
F
A
TT
P
EH
LI
GL
R
I
LIGI
S
L
G
G
DY
S
VG
H
T
LL
A
EFSP
R
R
H
RG
ILLGAFS
--------
VV
W
T
VG
YVL
AS
I
A
G
H
HFISENPEA
WRW
L
L
A
SAA
L
P
A
LLI
TLL
RW
GT
--------------------
PESPRWLLR
Q
GR
F
AEA
H
AI
V
H
R
Y
FG
PH
V
LLGD
E
V
VTA
T
H
K
H
I
K
-----
--
--------------
T
LF
SS
R
YW
RRT
A
F
NSVFFV
C
L
--
VIP
W
F
V
IYTW
L
PTI
AQTI
GL
-
-
-
E
D
A
LTA
S
LMLN
A
LL
I
V
GA
-----
L
LG
L
V
LT
H
LLA
H
R
KF
L
L
GS
F
LL
L
AAT
L
V
V
MA
C
L
PS
-
G
SS
--------
L
T
LL
L
F
V
-
L
F
ST
T
I
SA
VS
NL
VG
I
L
P
A
E
S
FPTDIR
SL
GVGF
AT
A
M
SR
L
GA
A
VST
GL
LP
W
------
V
L
A
Q
W
G
-
M
Q
VT
L
LL
L
A
T
V
L
L
V
G
F
V
V
T
WL
W
APET
K
A
L
P
L
VAA
G
NV
fig|344601.5.peg.2333
Escherichia coli B171 (33-459/469)
DDLPL
N
RFH
C
RI
AALT
F
G
AH
L
T
DGYVL
GV
IG
Y
A
I
I
QLTPA
MQ
L
TP
F
MA
G
MI
G
GSA
L
L
GLF
L
GSL
VL
G
W
ISD
HI
GR
Q
K
I
F
T
F
S
F
L
L
I
T
L
AS
FLQF
F
A
TT
P
EH
LI
GL
R
I
LIGI
S
L
G
G
DY
S
VG
H
T
LL
A
EFSP
R
R
H
RG
ILLGAFS
--------
VV
W
T
VG
YVL
AS
I
A
G
H
HFISENPEA
WRW
L
L
A
SAA
L
P
A
LLI
TLL
RW
GT
--------------------
PESPRWLLR
Q
GR
F
AEA
H
AI
V
H
R
Y
FG
PH
V
LLGD
E
V
VTA
T
H
K
H
I
K
-----
--
--------------
T
LF
SS
R
YW
RRT
A
F
NSVFFV
C
L
--
VIP
W
F
V
IYTW
L
PTI
AQTI
GL
-
-
-
E
D
A
LTA
S
LMLN
A
LL
I
V
GA
-----
L
LG
L
V
LT
H
LLA
H
R
KF
L
L
GS
F
LL
L
AAT
L
V
V
MA
C
L
PS
-
G
SS
--------
L
T
LL
L
F
V
-
L
F
ST
T
I
SA
VS
NL
VG
I
L
P
A
E
S
FPTDIR
SL
GVGF
AT
A
M
SR
L
GA
A
VST
GL
LP
W
------
V
L
A
Q
W
G
-
M
Q
VT
L
LL
L
A
T
V
L
L
V
G
F
V
V
T
WL
W
APET
K
A
L
P
L
VAA
G
NV
fig|340185.3.peg.3451
Escherichia coli E22 (33-459/469)
DDLPL
N
RFH
C
RI
AALT
F
G
AH
L
T
DGYVL
GV
IG
Y
A
I
I
QLTPA
MQ
L
TP
F
MA
G
MI
G
GSA
L
L
GLF
L
GSL
VL
G
W
ISD
HI
GR
Q
K
I
F
T
F
S
F
L
L
I
T
L
AS
FLQF
F
A
TT
P
EH
LI
GL
R
I
LIGI
S
L
G
G
DY
S
VG
H
T
LL
A
EFSP
R
R
H
RG
ILLGAFS
--------
VV
W
T
VG
YVL
AS
I
A
G
H
HFISENPEA
WRW
L
L
A
SAA
L
P
A
LLI
TLL
RW
GT
--------------------
PESPRWLLR
Q
GR
F
AEA
H
AI
V
H
R
Y
FG
PH
V
LLGD
E
V
VTA
T
H
K
H
I
K
-----
--
--------------
T
LF
SS
R
YW
RRT
A
F
NSVFFV
C
L
--
VIP
W
F
V
IYTW
L
PTI
AQTI
GL
-
-
-
E
D
A
LTA
S
LMLN
A
LL
I
V
GA
-----
L
LG
L
V
LT
H
LLA
H
R
KF
L
L
GS
F
LL
L
AAT
L
V
V
MA
C
L
PS
-
G
SS
--------
L
T
LL
L
F
V
-
L
F
ST
T
I
SA
VS
NL
VG
I
L
P
A
E
S
FPTDIR
SL
GVGF
AT
A
M
SR
L
GA
A
VST
GL
LP
W
------
V
L
A
Q
W
G
-
M
Q
VT
L
LL
L
A
T
V
L
L
V
G
F
V
V
T
WL
W
APET
K
A
L
P
L
VAA
G
NV
fig|585395.4.peg.3467
Escherichia coli O103:H2 str. 12009 (33-459/469)
DDLPL
N
RFH
C
RI
AALT
F
G
AH
L
T
DGYVL
GV
IG
Y
A
I
I
QLTPA
MQ
L
TP
F
MA
G
MI
G
GSA
L
L
GLF
L
GSL
VL
G
W
ISD
HI
GR
Q
K
I
F
T
F
S
F
L
L
I
T
L
AS
FLQF
F
A
TT
P
EH
LI
GL
R
I
LIGI
S
L
G
G
DY
S
VG
H
T
LL
A
EFSP
R
R
H
RG
ILLGAFS
--------
VV
W
T
VG
YVL
AS
I
A
G
H
HFISENPEA
WRW
L
L
A
SAA
L
P
A
LLI
TLL
RW
GT
--------------------
PESPRWLLR
Q
GR
F
AEA
H
AI
V
H
R
Y
FG
PH
V
LLGD
E
V
VTA
T
H
K
H
I
K
-----
--
--------------
T
LF
SS
R
YW
RRT
A
F
NSVFFV
C
L
--
VIP
W
F
V
IYTW
L
PTI
AQTI
GL
-
-
-
E
D
A
LTA
S
LMLN
A
LL
I
V
GA
-----
L
LG
L
V
LT
H
LLA
H
R
KF
L
L
GS
F
LL
L
AAT
L
V
V
MA
C
L
PS
-
G
SS
--------
L
T
LL
L
F
V
-
L
F
ST
T
I
SA
VS
NL
VG
I
L
P
A
E
S
FPTDIR
SL
GVGF
AT
A
M
SR
L
GA
A
VST
GL
LP
W
------
V
L
A
Q
W
G
-
M
Q
VT
L
LL
L
A
T
V
L
L
V
G
F
V
V
T
WL
W
APET
K
A
L
P
L
VAA
G
NV
fig|550677.3.peg.3298
Escherichia coli B354 (9-435/445)
DDLPL
N
RFH
C
RI
AALT
F
G
AH
L
T
DGYVL
GV
IG
Y
A
I
I
QLTPA
MQ
L
TP
F
MA
G
MI
G
GSA
L
L
GLF
I
GSL
VL
G
G
ISD
HI
GR
Q
K
I
F
T
F
S
F
L
L
I
T
L
AS
FLQF
F
A
TT
P
EH
LI
GL
R
I
LIGIG
L
G
G
DY
S
VG
H
T
LL
A
EFSP
R
R
H
RG
ILLGAFS
--------
VV
W
T
VG
YVL
AS
I
A
G
H
HFISESPEA
WRW
L
L
A
SAA
L
P
A
LLI
TLL
RW
GT
--------------------
PESPRWLLR
Q
GR
F
AEA
H
AI
V
H
R
Y
FG
PH
V
LLGD
E
V
ATA
T
H
K
H
I
K
-----
--
--------------
T
LF
SS
R
YW
RRT
A
F
NSVFFV
C
L
--
VIP
W
F
V
IYTW
L
PTI
AQTI
GL
-
-
-
E
D
A
LTA
S
LMLN
A
LL
I
V
GA
-----
L
LG
L
V
LT
H
LLA
H
R
KF
L
L
GS
F
LL
L
AAT
L
V
V
MA
C
L
PS
-
G
SS
--------
L
T
LL
L
F
V
-
L
F
ST
T
I
SA
VS
NL
VG
I
L
P
A
E
S
FPTDIR
SL
GVGF
AT
A
M
SR
L
GA
A
VST
GL
LP
W
------
V
L
A
Q
W
G
-
M
Q
VT
L
LL
L
A
A
V
L
L
V
G
F
V
V
T
WL
W
APET
K
A
L
P
L
VAA
G
NV
fig|155864.1.peg.3630
Escherichia coli O157:H7 EDL933 (33-459/469)
DDLPL
N
RFH
C
RI
AALT
F
G
AH
L
T
DGYVL
GV
IG
Y
A
I
I
QLTPA
MQ
L
TP
F
MA
G
MI
G
GSA
H
L
GLF
L
GSL
VL
G
W
ISD
HI
GR
Q
K
I
F
T
F
S
F
L
L
I
T
L
AS
FLQF
F
A
TT
P
EH
LI
GL
R
I
LIGIG
L
G
G
DY
S
VG
H
T
LL
A
EFSP
R
R
H
RG
VLLGAFS
--------
VV
W
T
VG
YVL
AS
I
A
G
H
HFISENPEA
WRW
L
L
A
SAA
L
P
A
LLI
TLL
RW
GT
--------------------
PESPRWLLR
Q
GR
F
AEA
H
AI
V
H
R
Y
FG
PH
V
LLGD
E
V
ATA
T
H
K
H
I
K
-----
--
--------------
T
LF
SS
R
YW
RRT
A
F
NSVFFV
C
L
--
VIP
W
F
V
IYTW
L
PTI
AQTI
GL
-
-
-
E
D
A
LTA
S
LMLN
A
LL
I
V
GA
-----
L
LG
L
V
LT
H
LLA
H
R
KF
L
L
GS
F
LL
L
AAT
L
V
V
MA
C
L
PS
-
G
SS
--------
L
T
LL
L
F
V
-
L
F
ST
T
I
SA
VS
NL
VG
I
L
P
A
E
S
FPTDIR
SL
GVGF
AT
A
M
SR
L
GA
A
VST
GL
LP
W
------
V
L
A
Q
W
G
-
M
Q
VT
L
LL
L
A
A
V
L
L
A
G
F
V
V
T
WL
W
APET
K
A
L
P
L
VAA
G
NV
fig|344610.3.peg.3677
Escherichia coli 53638 (33-459/469)
DDLPL
N
RFH
C
RI
AALT
F
G
AH
L
T
DGYVL
GV
IG
Y
A
I
I
QLTPA
MQ
L
TP
F
MA
G
MI
G
GSA
L
L
GLF
L
GSL
VL
G
W
ISD
HI
GR
Q
K
I
F
T
F
S
F
L
L
I
T
L
AS
FLQF
F
A
TT
P
EH
LI
GL
R
I
LIGIG
L
G
G
DY
S
VG
H
T
LL
A
EFSP
R
R
H
RG
ILLGAFS
--------
VV
W
T
VG
YVL
AS
I
A
G
H
HFISENPEA
WRW
L
L
A
SAA
L
P
A
LLI
TLL
RW
GT
--------------------
PESPRWLLR
Q
GR
F
AEA
H
AI
V
H
R
Y
FG
PH
V
LLGD
E
V
VTA
T
H
K
H
I
K
-----
--
--------------
T
LF
SS
R
YW
RRT
A
F
NSVFFV
C
L
--
VIP
W
F
V
IYTW
L
PTI
AQTI
GL
-
-
-
E
D
A
LTA
S
LMLN
A
LL
I
V
GA
-----
L
LG
L
V
LT
H
LLA
H
R
KF
L
L
GS
F
LL
L
AAT
L
V
V
MA
C
L
PS
-
G
SS
--------
L
T
LL
L
F
V
-
L
F
ST
T
I
SA
VS
NL
VG
I
L
P
A
E
S
FPTDIR
SL
GVGF
AT
A
M
SR
L
GA
A
VST
GL
LP
W
------
V
L
A
Q
W
G
-
M
Q
VT
L
LL
L
A
T
V
L
L
V
G
F
V
V
T
WL
W
APET
K
A
L
P
L
VAA
G
NV
fig|344610.7.peg.3503
Escherichia coli 53638 (33-459/469)
DDLPL
N
RFH
C
RI
AALT
F
G
AH
L
T
DGYVL
GV
IG
Y
A
I
I
QLTPA
MQ
L
TP
F
MA
G
MI
G
GSA
L
L
GLF
L
GSL
VL
G
W
ISD
HI
GR
Q
K
I
F
T
F
S
F
L
L
I
T
L
AS
FLQF
F
A
TT
P
EH
LI
GL
R
I
LIGIG
L
G
G
DY
S
VG
H
T
LL
A
EFSP
R
R
H
RG
ILLGAFS
--------
VV
W
T
VG
YVL
AS
I
A
G
H
HFISENPEA
WRW
L
L
A
SAA
L
P
A
LLI
TLL
RW
GT
--------------------
PESPRWLLR
Q
GR
F
AEA
H
AI
V
H
R
Y
FG
PH
V
LLGD
E
V
VTA
T
H
K
H
I
K
-----
--
--------------
T
LF
SS
R
YW
RRT
A
F
NSVFFV
C
L
--
VIP
W
F
V
IYTW
L
PTI
AQTI
GL
-
-
-
E
D
A
LTA
S
LMLN
A
LL
I
V
GA
-----
L
LG
L
V
LT
H
LLA
H
R
KF
L
L
GS
F
LL
L
AAT
L
V
V
MA
C
L
PS
-
G
SS
--------
L
T
LL
L
F
V
-
L
F
ST
T
I
SA
VS
NL
VG
I
L
P
A
E
S
FPTDIR
SL
GVGF
AT
A
M
SR
L
GA
A
VST
GL
LP
W
------
V
L
A
Q
W
G
-
M
Q
VT
L
LL
L
A
T
V
L
L
V
G
F
V
V
T
WL
W
APET
K
A
L
P
L
VAA
G
NV
fig|481805.3.peg.1003
Escherichia coli ATCC 8739 (33-459/469)
DDLPL
N
RFH
C
RI
AALT
F
G
AH
L
T
DGYVL
GV
IG
Y
A
I
I
QLTPA
MQ
L
TP
F
MA
G
MI
G
GSA
L
L
GLF
L
GSL
VL
G
W
ISD
HI
GR
Q
K
I
F
T
F
S
F
L
L
I
T
L
AS
FLQF
F
A
TT
P
EH
LI
GL
R
I
LIGIG
L
G
G
DY
S
VG
H
T
LL
A
EFSP
R
R
H
RG
ILLGAFS
--------
VV
W
T
VG
YVL
AS
I
A
G
H
HFISENPEA
WRW
L
L
A
SAA
L
P
A
LLI
TLL
RW
GT
--------------------
PESPRWLLR
Q
GR
F
AEA
H
AI
V
H
R
Y
FG
PH
V
LLGD
E
V
VTA
T
H
K
H
I
K
-----
--
--------------
T
LF
SS
R
YW
RRT
A
F
NSVFFV
C
L
--
VIP
W
F
V
IYTW
L
PTI
AQTI
GL
-
-
-
E
D
A
LTA
S
LMLN
A
LL
I
V
GA
-----
L
LG
L
V
LT
H
LLA
H
R
KF
L
L
GS
F
LL
L
AAT
L
V
V
MA
C
L
PS
-
G
SS
--------
L
T
LL
L
F
V
-
L
F
ST
T
I
SA
VS
NL
VG
I
L
P
A
E
S
FPTDIR
SL
GVGF
AT
A
M
SR
L
GA
A
VST
GL
LP
W
------
V
L
A
Q
W
G
-
M
Q
VT
L
LL
L
A
T
V
L
L
V
G
F
V
V
T
WL
W
APET
K
A
L
P
L
VAA
G
NV
fig|481805.6.peg.1000
Escherichia coli ATCC 8739 (33-459/469)
DDLPL
N
RFH
C
RI
AALT
F
G
AH
L
T
DGYVL
GV
IG
Y
A
I
I
QLTPA
MQ
L
TP
F
MA
G
MI
G
GSA
L
L
GLF
L
GSL
VL
G
W
ISD
HI
GR
Q
K
I
F
T
F
S
F
L
L
I
T
L
AS
FLQF
F
A
TT
P
EH
LI
GL
R
I
LIGIG
L
G
G
DY
S
VG
H
T
LL
A
EFSP
R
R
H
RG
ILLGAFS
--------
VV
W
T
VG
YVL
AS
I
A
G
H
HFISENPEA
WRW
L
L
A
SAA
L
P
A
LLI
TLL
RW
GT
--------------------
PESPRWLLR
Q
GR
F
AEA
H
AI
V
H
R
Y
FG
PH
V
LLGD
E
V
VTA
T
H
K
H
I
K
-----
--
--------------
T
LF
SS
R
YW
RRT
A
F
NSVFFV
C
L
--
VIP
W
F
V
IYTW
L
PTI
AQTI
GL
-
-
-
E
D
A
LTA
S
LMLN
A
LL
I
V
GA
-----
L
LG
L
V
LT
H
LLA
H
R
KF
L
L
GS
F
LL
L
AAT
L
V
V
MA
C
L
PS
-
G
SS
--------
L
T
LL
L
F
V
-
L
F
ST
T
I
SA
VS
NL
VG
I
L
P
A
E
S
FPTDIR
SL
GVGF
AT
A
M
SR
L
GA
A
VST
GL
LP
W
------
V
L
A
Q
W
G
-
M
Q
VT
L
LL
L
A
T
V
L
L
V
G
F
V
V
T
WL
W
APET
K
A
L
P
L
VAA
G
NV
fig|413997.3.peg.2743
Escherichia coli B str. REL606 (33-459/469)
DDLPL
N
RFH
C
RI
AALT
F
G
AH
L
T
DGYVL
GV
IG
Y
A
I
I
QLTPA
MQ
L
TP
F
MA
G
MI
G
GSA
L
L
GLF
L
GSL
VL
G
W
ISD
HI
GR
Q
K
I
F
T
F
S
F
L
L
I
T
L
AS
FLQF
F
A
TT
P
EH
LI
GL
R
I
LIGIG
L
G
G
DY
S
VG
H
T
LL
A
EFSP
R
R
H
RG
ILLGAFS
--------
VV
W
T
VG
YVL
AS
I
A
G
H
HFISENPEA
WRW
L
L
A
SAA
L
P
A
LLI
TLL
RW
GT
--------------------
PESPRWLLR
Q
GR
F
AEA
H
AI
V
H
R
Y
FG
PH
V
LLGD
E
V
VTA
T
H
K
H
I
K
-----
--
--------------
T
LF
SS
R
YW
RRT
A
F
NSVFFV
C
L
--
VIP
W
F
V
IYTW
L
PTI
AQTI
GL
-
-
-
E
D
A
LTA
S
LMLN
A
LL
I
V
GA
-----
L
LG
L
V
LT
H
LLA
H
R
KF
L
L
GS
F
LL
L
AAT
L
V
V
MA
C
L
PS
-
G
SS
--------
L
T
LL
L
F
V
-
L
F
ST
T
I
SA
VS
NL
VG
I
L
P
A
E
S
FPTDIR
SL
GVGF
AT
A
M
SR
L
GA
A
VST
GL
LP
W
------
V
L
A
Q
W
G
-
M
Q
VT
L
LL
L
A
T
V
L
L
V
G
F
V
V
T
WL
W
APET
K
A
L
P
L
VAA
G
NV
fig|550672.3.peg.2991
Escherichia coli B088 (33-459/469)
DDLPL
N
RFH
C
RI
AALT
F
G
AH
L
T
DGYVL
GV
IG
Y
A
I
I
QLTPA
MQ
L
TP
F
MA
G
MI
G
GSA
L
L
GLF
L
GSL
VL
G
W
ISD
HI
GR
Q
K
I
F
T
F
S
F
L
L
I
T
L
AS
FLQF
F
A
TT
P
EH
LI
GL
R
I
LIGIG
L
G
G
DY
S
VG
H
T
LL
A
EFSP
R
R
H
RG
ILLGAFS
--------
VV
W
T
VG
YVL
AS
I
A
G
H
HFISENPEA
WRW
L
L
A
SAA
L
P
A
LLI
TLL
RW
GT
--------------------
PESPRWLLR
Q
GR
F
AEA
H
AI
V
H
R
Y
FG
PH
V
LLGD
E
V
VTA
T
H
K
H
I
K
-----
--
--------------
T
LF
SS
R
YW
RRT
A
F
NSVFFV
C
L
--
VIP
W
F
V
IYTW
L
PTI
AQTI
GL
-
-
-
E
D
A
LTA
S
LMLN
A
LL
I
V
GA
-----
L
LG
L
V
LT
H
LLA
H
R
KF
L
L
GS
F
LL
L
AAT
L
V
V
MA
C
L
PS
-
G
SS
--------
L
T
LL
L
F
V
-
L
F
ST
T
I
SA
VS
NL
VG
I
L
P
A
E
S
FPTDIR
SL
GVGF
AT
A
M
SR
L
GA
A
VST
GL
LP
W
------
V
L
A
Q
W
G
-
M
Q
VT
L
LL
L
A
T
V
L
L
V
G
F
V
V
T
WL
W
APET
K
A
L
P
L
VAA
G
NV
fig|511693.5.peg.2758
Escherichia coli BL21 (33-459/469)
DDLPL
N
RFH
C
RI
AALT
F
G
AH
L
T
DGYVL
GV
IG
Y
A
I
I
QLTPA
MQ
L
TP
F
MA
G
MI
G
GSA
L
L
GLF
L
GSL
VL
G
W
ISD
HI
GR
Q
K
I
F
T
F
S
F
L
L
I
T
L
AS
FLQF
F
A
TT
P
EH
LI
GL
R
I
LIGIG
L
G
G
DY
S
VG
H
T
LL
A
EFSP
R
R
H
RG
ILLGAFS
--------
VV
W
T
VG
YVL
AS
I
A
G
H
HFISENPEA
WRW
L
L
A
SAA
L
P
A
LLI
TLL
RW
GT
--------------------
PESPRWLLR
Q
GR
F
AEA
H
AI
V
H
R
Y
FG
PH
V
LLGD
E
V
VTA
T
H
K
H
I
K
-----
--
--------------
T
LF
SS
R
YW
RRT
A
F
NSVFFV
C
L
--
VIP
W
F
V
IYTW
L
PTI
AQTI
GL
-
-
-
E
D
A
LTA
S
LMLN
A
LL
I
V
GA
-----
L
LG
L
V
LT
H
LLA
H
R
KF
L
L
GS
F
LL
L
AAT
L
V
V
MA
C
L
PS
-
G
SS
--------
L
T
LL
L
F
V
-
L
F
ST
T
I
SA
VS
NL
VG
I
L
P
A
E
S
FPTDIR
SL
GVGF
AT
A
M
SR
L
GA
A
VST
GL
LP
W
------
V
L
A
Q
W
G
-
M
Q
VT
L
LL
L
A
T
V
L
L
V
G
F
V
V
T
WL
W
APET
K
A
L
P
L
VAA
G
NV
fig|469008.4.peg.981
Escherichia coli BL21(DE3) (33-459/469)
DDLPL
N
RFH
C
RI
AALT
F
G
AH
L
T
DGYVL
GV
IG
Y
A
I
I
QLTPA
MQ
L
TP
F
MA
G
MI
G
GSA
L
L
GLF
L
GSL
VL
G
W
ISD
HI
GR
Q
K
I
F
T
F
S
F
L
L
I
T
L
AS
FLQF
F
A
TT
P
EH
LI
GL
R
I
LIGIG
L
G
G
DY
S
VG
H
T
LL
A
EFSP
R
R
H
RG
ILLGAFS
--------
VV
W
T
VG
YVL
AS
I
A
G
H
HFISENPEA
WRW
L
L
A
SAA
L
P
A
LLI
TLL
RW
GT
--------------------
PESPRWLLR
Q
GR
F
AEA
H
AI
V
H
R
Y
FG
PH
V
LLGD
E
V
VTA
T
H
K
H
I
K
-----
--
--------------
T
LF
SS
R
YW
RRT
A
F
NSVFFV
C
L
--
VIP
W
F
V
IYTW
L
PTI
AQTI
GL
-
-
-
E
D
A
LTA
S
LMLN
A
LL
I
V
GA
-----
L
LG
L
V
LT
H
LLA
H
R
KF
L
L
GS
F
LL
L
AAT
L
V
V
MA
C
L
PS
-
G
SS
--------
L
T
LL
L
F
V
-
L
F
ST
T
I
SA
VS
NL
VG
I
L
P
A
E
S
FPTDIR
SL
GVGF
AT
A
M
SR
L
GA
A
VST
GL
LP
W
------
V
L
A
Q
W
G
-
M
Q
VT
L
LL
L
A
T
V
L
L
V
G
F
V
V
T
WL
W
APET
K
A
L
P
L
VAA
G
NV
fig|595496.3.peg.2748
Escherichia coli BW2952 (33-459/469)
DDLPL
N
RFH
C
RI
AALT
F
G
AH
L
T
DGYVL
GV
IG
Y
A
I
I
QLTPA
MQ
L
TP
F
MA
G
MI
G
GSA
L
L
GLF
L
GSL
VL
G
W
ISD
HI
GR
Q
K
I
F
T
F
S
F
L
L
I
T
L
AS
FLQF
F
A
TT
P
EH
LI
GL
R
I
LIGIG
L
G
G
DY
S
VG
H
T
LL
A
EFSP
R
R
H
RG
ILLGAFS
--------
VV
W
T
VG
YVL
AS
I
A
G
H
HFISENPEA
WRW
L
L
A
SAA
L
P
A
LLI
TLL
RW
GT
--------------------
PESPRWLLR
Q
GR
F
AEA
H
AI
V
H
R
Y
FG
PH
V
LLGD
E
V
VTA
T
H
K
H
I
K
-----
--
--------------
T
LF
SS
R
YW
RRT
A
F
NSVFFV
C
L
--
VIP
W
F
V
IYTW
L
PTI
AQTI
GL
-
-
-
E
D
A
LTA
S
LMLN
A
LL
I
V
GA
-----
L
LG
L
V
LT
H
LLA
H
R
KF
L
L
GS
F
LL
L
AAT
L
V
V
MA
C
L
PS
-
G
SS
--------
L
T
LL
L
F
V
-
L
F
ST
T
I
SA
VS
NL
VG
I
L
P
A
E
S
FPTDIR
SL
GVGF
AT
A
M
SR
L
GA
A
VST
GL
LP
W
------
V
L
A
Q
W
G
-
M
Q
VT
L
LL
L
A
T
V
L
L
V
G
F
V
V
T
WL
W
APET
K
A
L
P
L
VAA
G
NV
fig|536056.3.peg.960
Escherichia coli DH1 (33-459/469)
DDLPL
N
RFH
C
RI
AALT
F
G
AH
L
T
DGYVL
GV
IG
Y
A
I
I
QLTPA
MQ
L
TP
F
MA
G
MI
G
GSA
L
L
GLF
L
GSL
VL
G
W
ISD
HI
GR
Q
K
I
F
T
F
S
F
L
L
I
T
L
AS
FLQF
F
A
TT
P
EH
LI
GL
R
I
LIGIG
L
G
G
DY
S
VG
H
T
LL
A
EFSP
R
R
H
RG
ILLGAFS
--------
VV
W
T
VG
YVL
AS
I
A
G
H
HFISENPEA
WRW
L
L
A
SAA
L
P
A
LLI
TLL
RW
GT
--------------------
PESPRWLLR
Q
GR
F
AEA
H
AI
V
H
R
Y
FG
PH
V
LLGD
E
V
VTA
T
H
K
H
I
K
-----
--
--------------
T
LF
SS
R
YW
RRT
A
F
NSVFFV
C
L
--
VIP
W
F
V
IYTW
L
PTI
AQTI
GL
-
-
-
E
D
A
LTA
S
LMLN
A
LL
I
V
GA
-----
L
LG
L
V
LT
H
LLA
H
R
KF
L
L
GS
F
LL
L
AAT
L
V
V
MA
C
L
PS
-
G
SS
--------
L
T
LL
L
F
V
-
L
F
ST
T
I
SA
VS
NL
VG
I
L
P
A
E
S
FPTDIR
SL
GVGF
AT
A
M
SR
L
GA
A
VST
GL
LP
W
------
V
L
A
Q
W
G
-
M
Q
VT
L
LL
L
A
T
V
L
L
V
G
F
V
V
T
WL
W
APET
K
A
L
P
L
VAA
G
NV
fig|340186.3.peg.2809
Escherichia coli E110019 (33-459/469)
DDLPL
N
RFH
C
RI
AALT
F
G
AH
L
T
DGYVL
GV
IG
Y
A
I
I
QLTPA
MQ
L
TP
F
MA
G
MI
G
GSA
L
L
GLF
L
GSL
VL
G
W
ISD
HI
GR
Q
K
I
F
T
F
S
F
L
L
I
T
L
AS
FLQF
F
A
TT
P
EH
LI
GL
R
I
LIGIG
L
G
G
DY
S
VG
H
T
LL
A
EFSP
R
R
H
RG
ILLGAFS
--------
VV
W
T
VG
YVL
AS
I
A
G
H
HFISENPEA
WRW
L
L
A
SAA
L
P
A
LLI
TLL
RW
GT
--------------------
PESPRWLLR
Q
GR
F
AEA
H
AI
V
H
R
Y
FG
PH
V
LLGD
E
V
VTA
T
H
K
H
I
K
-----
--
--------------
T
LF
SS
R
YW
RRT
A
F
NSVFFV
C
L
--
VIP
W
F
V
IYTW
L
PTI
AQTI
GL
-
-
-
E
D
A
LTA
S
LMLN
A
LL
I
V
GA
-----
L
LG
L
V
LT
H
LLA
H
R
KF
L
L
GS
F
LL
L
AAT
L
V
V
MA
C
L
PS
-
G
SS
--------
L
T
LL
L
F
V
-
L
F
ST
T
I
SA
VS
NL
VG
I
L
P
A
E
S
FPTDIR
SL
GVGF
AT
A
M
SR
L
GA
A
VST
GL
LP
W
------
V
L
A
Q
W
G
-
M
Q
VT
L
LL
L
A
T
V
L
L
V
G
F
V
V
T
WL
W
APET
K
A
L
P
L
VAA
G
NV
fig|340186.5.peg.2920
Escherichia coli E110019 (33-459/469)
DDLPL
N
RFH
C
RI
AALT
F
G
AH
L
T
DGYVL
GV
IG
Y
A
I
I
QLTPA
MQ
L
TP
F
MA
G
MI
G
GSA
L
L
GLF
L
GSL
VL
G
W
ISD
HI
GR
Q
K
I
F
T
F
S
F
L
L
I
T
L
AS
FLQF
F
A
TT
P
EH
LI
GL
R
I
LIGIG
L
G
G
DY
S
VG
H
T
LL
A
EFSP
R
R
H
RG
ILLGAFS
--------
VV
W
T
VG
YVL
AS
I
A
G
H
HFISENPEA
WRW
L
L
A
SAA
L
P
A
LLI
TLL
RW
GT
--------------------
PESPRWLLR
Q
GR
F
AEA
H
AI
V
H
R
Y
FG
PH
V
LLGD
E
V
VTA
T
H
K
H
I
K
-----
--
--------------
T
LF
SS
R
YW
RRT
A
F
NSVFFV
C
L
--
VIP
W
F
V
IYTW
L
PTI
AQTI
GL
-
-
-
E
D
A
LTA
S
LMLN
A
LL
I
V
GA
-----
L
LG
L
V
LT
H
LLA
H
R
KF
L
L
GS
F
LL
L
AAT
L
V
V
MA
C
L
PS
-
G
SS
--------
L
T
LL
L
F
V
-
L
F
ST
T
I
SA
VS
NL
VG
I
L
P
A
E
S
FPTDIR
SL
GVGF
AT
A
M
SR
L
GA
A
VST
GL
LP
W
------
V
L
A
Q
W
G
-
M
Q
VT
L
LL
L
A
T
V
L
L
V
G
F
V
V
T
WL
W
APET
K
A
L
P
L
VAA
G
NV
fig|331111.3.peg.787
Escherichia coli E24377A (33-459/469)
DDLPL
N
RFH
C
RI
AALT
F
G
AH
L
T
DGYVL
GV
IG
Y
A
I
I
QLTPA
MQ
L
TP
F
MA
G
MI
G
GSA
L
L
GLF
L
GSL
VL
G
W
ISD
HI
GR
Q
K
I
F
T
F
S
F
L
L
I
T
L
AS
FLQF
F
A
TT
P
EH
LI
GL
R
I
LIGIG
L
G
G
DY
S
VG
H
T
LL
A
EFSP
R
R
H
RG
ILLGAFS
--------
VV
W
T
VG
YVL
AS
I
A
G
H
HFISENPEA
WRW
L
L
A
SAA
L
P
A
LLI
TLL
RW
GT
--------------------
PESPRWLLR
Q
GR
F
AEA
H
AI
V
H
R
Y
FG
PH
V
LLGD
E
V
VTA
T
H
K
H
I
K
-----
--
--------------
T
LF
SS
R
YW
RRT
A
F
NSVFFV
C
L
--
VIP
W
F
V
IYTW
L
PTI
AQTI
GL
-
-
-
E
D
A
LTA
S
LMLN
A
LL
I
V
GA
-----
L
LG
L
V
LT
H
LLA
H
R
KF
L
L
GS
F
LL
L
AAT
L
V
V
MA
C
L
PS
-
G
SS
--------
L
T
LL
L
F
V
-
L
F
ST
T
I
SA
VS
NL
VG
I
L
P
A
E
S
FPTDIR
SL
GVGF
AT
A
M
SR
L
GA
A
VST
GL
LP
W
------
V
L
A
Q
W
G
-
M
Q
VT
L
LL
L
A
T
V
L
L
V
G
F
V
V
T
WL
W
APET
K
A
L
P
L
VAA
G
NV
fig|83333.1.peg.2727
Escherichia coli K12 (33-459/469)
DDLPL
N
RFH
C
RI
AALT
F
G
AH
L
T
DGYVL
GV
IG
Y
A
I
I
QLTPA
MQ
L
TP
F
MA
G
MI
G
GSA
L
L
GLF
L
GSL
VL
G
W
ISD
HI
GR
Q
K
I
F
T
F
S
F
L
L
I
T
L
AS
FLQF
F
A
TT
P
EH
LI
GL
R
I
LIGIG
L
G
G
DY
S
VG
H
T
LL
A
EFSP
R
R
H
RG
ILLGAFS
--------
VV
W
T
VG
YVL
AS
I
A
G
H
HFISENPEA
WRW
L
L
A
SAA
L
P
A
LLI
TLL
RW
GT
--------------------
PESPRWLLR
Q
GR
F
AEA
H
AI
V
H
R
Y
FG
PH
V
LLGD
E
V
VTA
T
H
K
H
I
K
-----
--
--------------
T
LF
SS
R
YW
RRT
A
F
NSVFFV
C
L
--
VIP
W
F
V
IYTW
L
PTI
AQTI
GL
-
-
-
E
D
A
LTA
S
LMLN
A
LL
I
V
GA
-----
L
LG
L
V
LT
H
LLA
H
R
KF
L
L
GS
F
LL
L
AAT
L
V
V
MA
C
L
PS
-
G
SS
--------
L
T
LL
L
F
V
-
L
F
ST
T
I
SA
VS
NL
VG
I
L
P
A
E
S
FPTDIR
SL
GVGF
AT
A
M
SR
L
GA
A
VST
GL
LP
W
------
V
L
A
Q
W
G
-
M
Q
VT
L
LL
L
A
T
V
L
L
V
G
F
V
V
T
WL
W
APET
K
A
L
P
L
VAA
G
NV
fig|595495.4.peg.2625
Escherichia coli KO11 (33-459/469)
DDLPL
N
RFH
C
RI
AALT
F
G
AH
L
T
DGYVL
GV
IG
Y
A
I
I
QLTPA
MQ
L
TP
F
MA
G
MI
G
GSA
L
L
GLF
L
GSL
VL
G
W
ISD
HI
GR
Q
K
I
F
T
F
S
F
L
L
I
T
L
AS
FLQF
F
A
TT
P
EH
LI
GL
R
I
LIGIG
L
G
G
DY
S
VG
H
T
LL
A
EFSP
R
R
H
RG
ILLGAFS
--------
VV
W
T
VG
YVL
AS
I
A
G
H
HFISENPEA
WRW
L
L
A
SAA
L
P
A
LLI
TLL
RW
GT
--------------------
PESPRWLLR
Q
GR
F
AEA
H
AI
V
H
R
Y
FG
PH
V
LLGD
E
V
VTA
T
H
K
H
I
K
-----
--
--------------
T
LF
SS
R
YW
RRT
A
F
NSVFFV
C
L
--
VIP
W
F
V
IYTW
L
PTI
AQTI
GL
-
-
-
E
D
A
LTA
S
LMLN
A
LL
I
V
GA
-----
L
LG
L
V
LT
H
LLA
H
R
KF
L
L
GS
F
LL
L
AAT
L
V
V
MA
C
L
PS
-
G
SS
--------
L
T
LL
L
F
V
-
L
F
ST
T
I
SA
VS
NL
VG
I
L
P
A
E
S
FPTDIR
SL
GVGF
AT
A
M
SR
L
GA
A
VST
GL
LP
W
------
V
L
A
Q
W
G
-
M
Q
VT
L
LL
L
A
T
V
L
L
V
G
F
V
V
T
WL
W
APET
K
A
L
P
L
VAA
G
NV
fig|749538.3.peg.3645
Escherichia coli MS 116-1 (33-459/469)
DDLPL
N
RFH
C
RI
AALT
F
G
AH
L
T
DGYVL
GV
IG
Y
A
I
I
QLTPA
MQ
L
TP
F
MA
G
MI
G
GSA
L
L
GLF
L
GSL
VL
G
W
ISD
HI
GR
Q
K
I
F
T
F
S
F
L
L
I
T
L
AS
FLQF
F
A
TT
P
EH
LI
GL
R
I
LIGIG
L
G
G
DY
S
VG
H
T
LL
A
EFSP
R
R
H
RG
ILLGAFS
--------
VV
W
T
VG
YVL
AS
I
A
G
H
HFISENPEA
WRW
L
L
A
SAA
L
P
A
LLI
TLL
RW
GT
--------------------
PESPRWLLR
Q
GR
F
AEA
H
AI
V
H
R
Y
FG
PH
V
LLGD
E
V
VTA
T
H
K
H
I
K
-----
--
--------------
T
LF
SS
R
YW
RRT
A
F
NSVFFV
C
L
--
VIP
W
F
V
IYTW
L
PTI
AQTI
GL
-
-
-
E
D
A
LTA
S
LMLN
A
LL
I
V
GA
-----
L
LG
L
V
LT
H
LLA
H
R
KF
L
L
GS
F
LL
L
AAT
L
V
V
MA
C
L
PS
-
G
SS
--------
L
T
LL
L
F
V
-
L
F
ST
T
I
SA
VS
NL
VG
I
L
P
A
E
S
FPTDIR
SL
GVGF
AT
A
M
SR
L
GA
A
VST
GL
LP
W
------
V
L
A
Q
W
G
-
M
Q
VT
L
LL
L
A
T
V
L
L
V
G
F
V
V
T
WL
W
APET
K
A
L
P
L
VAA
G
NV
fig|749545.3.peg.3164
Escherichia coli MS 182-1 (33-459/469)
DDLPL
N
RFH
C
RI
AALT
F
G
AH
L
T
DGYVL
GV
IG
Y
A
I
I
QLTPA
MQ
L
TP
F
MA
G
MI
G
GSA
L
L
GLF
L
GSL
VL
G
W
ISD
HI
GR
Q
K
I
F
T
F
S
F
L
L
I
T
L
AS
FLQF
F
A
TT
P
EH
LI
GL
R
I
LIGIG
L
G
G
DY
S
VG
H
T
LL
A
EFSP
R
R
H
RG
ILLGAFS
--------
VV
W
T
VG
YVL
AS
I
A
G
H
HFISENPEA
WRW
L
L
A
SAA
L
P
A
LLI
TLL
RW
GT
--------------------
PESPRWLLR
Q
GR
F
AEA
H
AI
V
H
R
Y
FG
PH
V
LLGD
E
V
VTA
T
H
K
H
I
K
-----
--
--------------
T
LF
SS
R
YW
RRT
A
F
NSVFFV
C
L
--
VIP
W
F
V
IYTW
L
PTI
AQTI
GL
-
-
-
E
D
A
LTA
S
LMLN
A
LL
I
V
GA
-----
L
LG
L
V
LT
H
LLA
H
R
KF
L
L
GS
F
LL
L
AAT
L
V
V
MA
C
L
PS
-
G
SS
--------
L
T
LL
L
F
V
-
L
F
ST
T
I
SA
VS
NL
VG
I
L
P
A
E
S
FPTDIR
SL
GVGF
AT
A
M
SR
L
GA
A
VST
GL
LP
W
------
V
L
A
Q
W
G
-
M
Q
VT
L
LL
L
A
T
V
L
L
V
G
F
V
V
T
WL
W
APET
K
A
L
P
L
VAA
G
NV
fig|585396.4.peg.3613
Escherichia coli O111:H- str. 11128 (33-459/469)
DDLPL
N
RFH
C
RI
AALT
F
G
AH
L
T
DGYVL
GV
IG
Y
A
I
I
QLTPA
MQ
L
TP
F
MA
G
MI
G
GSA
L
L
GLF
L
GSL
VL
G
W
ISD
HI
GR
Q
K
I
F
T
F
S
F
L
L
I
T
L
AS
FLQF
F
A
TT
P
EH
LI
GL
R
I
LIGIG
L
G
G
DY
S
VG
H
T
LL
A
EFSP
R
R
H
RG
ILLGAFS
--------
VV
W
T
VG
YVL
AS
I
A
G
H
HFISENPEA
WRW
L
L
A
SAA
L
P
A
LLI
TLL
RW
GT
--------------------
PESPRWLLR
Q
GR
F
AEA
H
AI
V
H
R
Y
FG
PH
V
LLGD
E
V
VTA
T
H
K
H
I
K
-----
--
--------------
T
LF
SS
R
YW
RRT
A
F
NSVFFV
C
L
--
VIP
W
F
V
IYTW
L
PTI
AQTI
GL
-
-
-
E
D
A
LTA
S
LMLN
A
LL
I
V
GA
-----
L
LG
L
V
LT
H
LLA
H
R
KF
L
L
GS
F
LL
L
AAT
L
V
V
MA
C
L
PS
-
G
SS
--------
L
T
LL
L
F
V
-
L
F
ST
T
I
SA
VS
NL
VG
I
L
P
A
E
S
FPTDIR
SL
GVGF
AT
A
M
SR
L
GA
A
VST
GL
LP
W
------
V
L
A
Q
W
G
-
M
Q
VT
L
LL
L
A
T
V
L
L
V
G
F
V
V
T
WL
W
APET
K
A
L
P
L
VAA
G
NV
fig|573235.3.peg.3924
Escherichia coli O26:H11 str. 11368 (33-459/469)
DDLPL
N
RFH
C
RI
AALT
F
G
AH
L
T
DGYVL
GV
IG
Y
A
I
I
QLTPA
MQ
L
TP
F
MA
G
MI
G
GSA
L
L
GLF
L
GSL
VL
G
W
ISD
HI
GR
Q
K
I
F
T
F
S
F
L
L
I
T
L
AS
FLQF
F
A
TT
P
EH
LI
GL
R
I
LIGIG
L
G
G
DY
S
VG
H
T
LL
A
EFSP
R
R
H
RG
ILLGAFS
--------
VV
W
T
VG
YVL
AS
I
A
G
H
HFISENPEA
WRW
L
L
A
SAA
L
P
A
LLI
TLL
RW
GT
--------------------
PESPRWLLR
Q
GR
F
AEA
H
AI
V
H
R
Y
FG
PH
V
LLGD
E
V
VTA
T
H
K
H
I
K
-----
--
--------------
T
LF
SS
R
YW
RRT
A
F
NSVFFV
C
L
--
VIP
W
F
V
IYTW
L
PTI
AQTI
GL
-
-
-
E
D
A
LTA
S
LMLN
A
LL
I
V
GA
-----
L
LG
L
V
LT
H
LLA
H
R
KF
L
L
GS
F
LL
L
AAT
L
V
V
MA
C
L
PS
-
G
SS
--------
L
T
LL
L
F
V
-
L
F
ST
T
I
SA
VS
NL
VG
I
L
P
A
E
S
FPTDIR
SL
GVGF
AT
A
M
SR
L
GA
A
VST
GL
LP
W
------
V
L
A
Q
W
G
-
M
Q
VT
L
LL
L
A
T
V
L
L
V
G
F
V
V
T
WL
W
APET
K
A
L
P
L
VAA
G
NV
fig|409438.11.peg.3199
Escherichia coli SE11 (33-459/469)
DDLPL
N
RFH
C
RI
AALT
F
G
AH
L
T
DGYVL
GV
IG
Y
A
I
I
QLTPA
MQ
L
TP
F
MA
G
MI
G
GSA
L
L
GLF
L
GSL
VL
G
W
ISD
HI
GR
Q
K
I
F
T
F
S
F
L
L
I
T
L
AS
FLQF
F
A
TT
P
EH
LI
GL
R
I
LIGIG
L
G
G
DY
S
VG
H
T
LL
A
EFSP
R
R
H
RG
ILLGAFS
--------
VV
W
T
VG
YVL
AS
I
A
G
H
HFISENPEA
WRW
L
L
A
SAA
L
P
A
LLI
TLL
RW
GT
--------------------
PESPRWLLR
Q
GR
F
AEA
H
AI
V
H
R
Y
FG
PH
V
LLGD
E
V
VTA
T
H
K
H
I
K
-----
--
--------------
T
LF
SS
R
YW
RRT
A
F
NSVFFV
C
L
--
VIP
W
F
V
IYTW
L
PTI
AQTI
GL
-
-
-
E
D
A
LTA
S
LMLN
A
LL
I
V
GA
-----
L
LG
L
V
LT
H
LLA
H
R
KF
L
L
GS
F
LL
L
AAT
L
V
V
MA
C
L
PS
-
G
SS
--------
L
T
LL
L
F
V
-
L
F
ST
T
I
SA
VS
NL
VG
I
L
P
A
E
S
FPTDIR
SL
GVGF
AT
A
M
SR
L
GA
A
VST
GL
LP
W
------
V
L
A
Q
W
G
-
M
Q
VT
L
LL
L
A
T
V
L
L
V
G
F
V
V
T
WL
W
APET
K
A
L
P
L
VAA
G
NV
fig|316385.5.peg.2895
Escherichia coli str. K-12 substr. DH10B (33-459/469)
DDLPL
N
RFH
C
RI
AALT
F
G
AH
L
T
DGYVL
GV
IG
Y
A
I
I
QLTPA
MQ
L
TP
F
MA
G
MI
G
GSA
L
L
GLF
L
GSL
VL
G
W
ISD
HI
GR
Q
K
I
F
T
F
S
F
L
L
I
T
L
AS
FLQF
F
A
TT
P
EH
LI
GL
R
I
LIGIG
L
G
G
DY
S
VG
H
T
LL
A
EFSP
R
R
H
RG
ILLGAFS
--------
VV
W
T
VG
YVL
AS
I
A
G
H
HFISENPEA
WRW
L
L
A
SAA
L
P
A
LLI
TLL
RW
GT
--------------------
PESPRWLLR
Q
GR
F
AEA
H
AI
V
H
R
Y
FG
PH
V
LLGD
E
V
VTA
T
H
K
H
I
K
-----
--
--------------
T
LF
SS
R
YW
RRT
A
F
NSVFFV
C
L
--
VIP
W
F
V
IYTW
L
PTI
AQTI
GL
-
-
-
E
D
A
LTA
S
LMLN
A
LL
I
V
GA
-----
L
LG
L
V
LT
H
LLA
H
R
KF
L
L
GS
F
LL
L
AAT
L
V
V
MA
C
L
PS
-
G
SS
--------
L
T
LL
L
F
V
-
L
F
ST
T
I
SA
VS
NL
VG
I
L
P
A
E
S
FPTDIR
SL
GVGF
AT
A
M
SR
L
GA
A
VST
GL
LP
W
------
V
L
A
Q
W
G
-
M
Q
VT
L
LL
L
A
T
V
L
L
V
G
F
V
V
T
WL
W
APET
K
A
L
P
L
VAA
G
NV
fig|340185.4.peg.3632
Escherichia coli E22 (2-428/438)
DDLPL
N
RFH
C
RI
AALT
F
G
AH
L
T
DGYVL
GV
IG
Y
A
I
I
QLTPA
MQ
L
TP
F
MA
G
MI
G
GSA
L
L
GLF
L
GSL
VL
G
W
ISD
HI
GR
Q
K
I
F
T
F
S
F
L
L
I
T
L
AS
FLQF
F
A
TT
P
EH
LI
GL
R
I
LIGI
S
L
G
G
DY
S
VG
H
T
LL
A
EFSP
R
R
H
RG
ILLGAFS
--------
VV
W
T
VG
YVL
AS
I
A
G
H
HFISENPEA
WRW
L
L
A
SAA
L
P
A
LLI
TLL
RW
GT
--------------------
PESPRWLLR
Q
GR
F
AEA
H
AI
V
H
R
Y
FG
PH
V
LLGD
E
V
VTA
T
H
K
H
I
K
-----
--
--------------
T
LF
SS
R
YW
RRT
A
F
NSVFFV
C
L
--
VIP
W
F
V
IYTW
L
PTI
AQTI
GL
-
-
-
E
D
A
LTA
S
LMLN
A
LL
I
V
GA
-----
L
LG
L
V
LT
H
LLA
H
R
KF
L
L
GS
F
LL
L
AAT
L
V
V
MA
C
L
PS
-
G
SS
--------
L
T
LL
L
F
V
-
L
F
ST
T
I
SA
VS
NL
VG
I
L
P
A
E
S
FPTDIR
SL
GVGF
AT
A
M
SR
L
GA
A
VST
GL
LP
W
------
V
L
A
Q
W
G
-
M
Q
VT
L
LL
L
A
T
V
L
L
V
G
F
V
V
T
WL
W
APET
K
A
L
P
L
VAA
G
NV
fig|585057.4.peg.3056
Escherichia coli IAI39 (9-435/445)
DDLPL
N
RFH
C
RI
AALT
F
G
AH
L
T
DGYVL
GV
IG
Y
A
I
I
QLTPA
MQ
L
TP
F
MA
G
MI
G
GSA
L
L
GLF
L
GSL
VL
G
W
ISD
HI
GR
Q
K
I
F
T
F
S
F
M
L
I
T
L
AS
FLQF
F
A
TT
P
EH
LI
GL
R
I
LIGIG
L
G
G
DY
S
VG
H
T
LL
A
EFSP
R
R
H
RG
ILLGAFS
--------
VV
W
T
VG
YVL
AS
I
A
G
H
HFISENPEA
WRW
L
L
A
SAA
L
P
A
LLI
TLL
RW
GT
--------------------
PESPRWLLR
Q
GR
F
AEA
H
AI
V
H
R
Y
L
G
PH
V
LLGD
E
V
AAA
T
H
K
H
I
K
-----
--
--------------
T
LF
SS
R
YW
RRT
A
F
NSVFFV
C
L
--
VIP
W
F
V
IYTW
L
PTI
AQTI
GL
-
-
-
E
D
A
LTA
S
LMLN
A
LL
I
V
GA
-----
L
LG
L
V
LT
H
LLA
H
R
KF
L
L
GS
F
LL
L
AAT
L
V
V
MA
C
L
PS
-
G
SS
--------
L
T
LL
L
F
V
-
L
F
ST
T
I
SA
VS
NL
VG
I
L
P
A
E
S
FPTDIR
SL
GVGF
AT
A
M
SR
L
GA
A
VST
GL
LP
W
------
V
L
A
Q
W
G
-
M
Q
A
T
L
LL
L
A
A
V
L
L
V
G
F
V
V
T
WL
W
APET
K
A
L
P
L
VAA
G
NV
fig|585057.6.peg.3062
Escherichia coli IAI39 (9-435/445)
DDLPL
N
RFH
C
RI
AALT
F
G
AH
L
T
DGYVL
GV
IG
Y
A
I
I
QLTPA
MQ
L
TP
F
MA
G
MI
G
GSA
L
L
GLF
L
GSL
VL
G
W
ISD
HI
GR
Q
K
I
F
T
F
S
F
M
L
I
T
L
AS
FLQF
F
A
TT
P
EH
LI
GL
R
I
LIGIG
L
G
G
DY
S
VG
H
T
LL
A
EFSP
R
R
H
RG
ILLGAFS
--------
VV
W
T
VG
YVL
AS
I
A
G
H
HFISENPEA
WRW
L
L
A
SAA
L
P
A
LLI
TLL
RW
GT
--------------------
PESPRWLLR
Q
GR
F
AEA
H
AI
V
H
R
Y
L
G
PH
V
LLGD
E
V
AAA
T
H
K
H
I
K
-----
--
--------------
T
LF
SS
R
YW
RRT
A
F
NSVFFV
C
L
--
VIP
W
F
V
IYTW
L
PTI
AQTI
GL
-
-
-
E
D
A
LTA
S
LMLN
A
LL
I
V
GA
-----
L
LG
L
V
LT
H
LLA
H
R
KF
L
L
GS
F
LL
L
AAT
L
V
V
MA
C
L
PS
-
G
SS
--------
L
T
LL
L
F
V
-
L
F
ST
T
I
SA
VS
NL
VG
I
L
P
A
E
S
FPTDIR
SL
GVGF
AT
A
M
SR
L
GA
A
VST
GL
LP
W
------
V
L
A
Q
W
G
-
M
Q
A
T
L
LL
L
A
A
V
L
L
V
G
F
V
V
T
WL
W
APET
K
A
L
P
L
VAA
G
NV
fig|331112.3.peg.2723
Escherichia coli HS (33-459/469)
DDLPL
N
RFH
C
RI
AALT
F
G
AH
L
T
DGYVL
GV
IG
Y
A
I
I
QLTPA
MQ
L
TP
F
MA
G
MI
G
GSA
L
L
GLF
L
GSL
VL
G
W
ISD
HI
GR
Q
K
I
F
T
F
S
F
L
L
I
T
L
AS
FLQF
F
A
TK
P
EH
LI
GL
R
I
LIGIG
L
G
G
DY
S
VG
H
T
LL
A
EFSP
R
R
H
RG
ILLGAFS
--------
VV
W
T
VG
YVL
AS
I
A
G
H
HFISENPEA
WRW
L
L
A
SAA
L
P
A
LLI
TLL
RW
GT
--------------------
PESPRWLLR
Q
GR
F
AEA
H
AI
V
H
R
Y
FG
PH
V
LLGD
E
V
VTA
T
H
K
H
I
K
-----
--
--------------
T
LF
SS
R
YW
RRT
A
F
NSVFFV
C
L
--
VIP
W
F
V
IYTW
L
PTI
AQTI
GL
-
-
-
E
D
A
LTA
S
LMLN
A
LL
I
V
GA
-----
L
LG
L
V
LT
H
LLA
H
R
KF
L
L
GS
F
LL
L
AAT
L
V
V
MA
C
L
P
A
-
G
SS
--------
L
T
LL
L
F
V
-
L
F
ST
T
I
SA
VS
NL
VG
I
L
P
A
E
S
FPTDIR
SL
GVGF
AT
A
M
SR
L
GA
A
VST
GL
LP
W
------
V
L
A
Q
W
G
-
M
Q
VT
L
LL
L
A
T
V
L
L
V
G
F
V
V
T
WL
W
APET
K
A
L
P
L
VAA
G
NV
fig|1040638.4.peg.2652
Escherichia coli O104:H4 str. LB226692 (9-435/445)
DDLPL
N
RFH
C
RI
AALT
F
G
AH
L
T
DGYVL
GV
IG
Y
A
I
I
QLTPA
MQ
L
TP
F
MA
G
MI
G
GSA
L
L
GLF
L
GSL
VL
G
W
ISD
HI
GR
Q
K
I
F
T
F
S
F
L
L
I
T
L
AS
FLQF
F
A
TT
P
EH
LI
GL
R
I
LIGIG
L
G
G
DY
S
VG
H
T
LL
A
EFSP
R
R
H
RG
ILLGAFS
--------
VV
W
T
VG
YVL
AS
I
A
G
H
HFISENPEA
WRW
L
L
A
SAA
L
P
A
LLI
TLL
RW
GT
--------------------
PESPRWLLR
Q
GR
F
AEA
H
AI
V
H
R
Y
FG
PH
V
LLGD
E
V
VTA
T
H
K
H
I
K
-----
--
--------------
T
LF
SS
R
YW
RRT
A
F
NSVFFV
C
L
--
VIP
W
F
V
IYTW
L
PTI
AQTI
GL
-
-
-
E
D
A
LTA
S
LMLN
A
LL
I
V
GA
-----
L
LG
L
V
LT
H
LLA
H
R
KF
L
L
GS
F
LL
L
AAT
L
V
V
MA
C
L
PS
-
G
SS
--------
L
T
LL
L
F
V
-
L
F
ST
T
I
SA
VS
NL
VG
I
L
P
A
E
S
FPTDIR
SL
GVGF
AT
A
M
SR
L
GA
A
VST
GL
LP
W
------
V
L
A
Q
W
G
-
M
Q
VT
L
LL
L
A
T
V
L
L
V
G
F
V
V
T
WL
W
APET
K
A
L
P
L
VAA
G
NV
fig|6666666.5357.peg.4592
Escherichia coli TY-2482 (9-435/445)
DDLPL
N
RFH
C
RI
AALT
F
G
AH
L
T
DGYVL
GV
IG
Y
A
I
I
QLTPA
MQ
L
TP
F
MA
G
MI
G
GSA
L
L
GLF
L
GSL
VL
G
W
ISD
HI
GR
Q
K
I
F
T
F
S
F
L
L
I
T
L
AS
FLQF
F
A
TT
P
EH
LI
GL
R
I
LIGIG
L
G
G
DY
S
VG
H
T
LL
A
EFSP
R
R
H
RG
ILLGAFS
--------
VV
W
T
VG
YVL
AS
I
A
G
H
HFISENPEA
WRW
L
L
A
SAA
L
P
A
LLI
TLL
RW
GT
--------------------
PESPRWLLR
Q
GR
F
AEA
H
AI
V
H
R
Y
FG
PH
V
LLGD
E
V
VTA
T
H
K
H
I
K
-----
--
--------------
T
LF
SS
R
YW
RRT
A
F
NSVFFV
C
L
--
VIP
W
F
V
IYTW
L
PTI
AQTI
GL
-
-
-
E
D
A
LTA
S
LMLN
A
LL
I
V
GA
-----
L
LG
L
V
LT
H
LLA
H
R
KF
L
L
GS
F
LL
L
AAT
L
V
V
MA
C
L
PS
-
G
SS
--------
L
T
LL
L
F
V
-
L
F
ST
T
I
SA
VS
NL
VG
I
L
P
A
E
S
FPTDIR
SL
GVGF
AT
A
M
SR
L
GA
A
VST
GL
LP
W
------
V
L
A
Q
W
G
-
M
Q
VT
L
LL
L
A
T
V
L
L
V
G
F
V
V
T
WL
W
APET
K
A
L
P
L
VAA
G
NV
fig|585055.6.peg.3080
Escherichia coli 55989 (9-435/445)
DDLPL
N
RFH
C
RI
AALT
F
G
AH
L
T
DGYVL
GV
IG
Y
A
I
I
QLTPA
MQ
L
TP
F
MA
G
MI
G
GSA
L
L
GLF
L
GSL
VL
G
W
ISD
HI
GR
Q
K
I
F
T
F
S
F
L
L
I
T
L
AS
FLQF
F
A
TT
P
EH
LI
GL
R
I
LIGIG
L
G
G
DY
S
VG
H
T
LL
A
EFSP
R
R
H
RG
ILLGAFS
--------
VV
W
T
VG
YVL
AS
I
A
G
H
HFISENPEA
WRW
L
L
A
SAA
L
P
A
LLI
TLL
RW
GT
--------------------
PESPRWLLR
Q
GR
F
AEA
H
AI
V
H
R
Y
FG
PH
V
LLGD
E
V
VTA
T
H
K
H
I
K
-----
--
--------------
T
LF
SS
R
YW
RRT
A
F
NSVFFV
C
L
--
VIP
W
F
V
IYTW
L
PTI
AQTI
GL
-
-
-
E
D
A
LTA
S
LMLN
A
LL
I
V
GA
-----
L
LG
L
V
LT
H
LLA
H
R
KF
L
L
GS
F
LL
L
AAT
L
V
V
MA
C
L
PS
-
G
SS
--------
L
T
LL
L
F
V
-
L
F
ST
T
I
SA
VS
NL
VG
I
L
P
A
E
S
FPTDIR
SL
GVGF
AT
A
M
SR
L
GA
A
VST
GL
LP
W
------
V
L
A
Q
W
G
-
M
Q
VT
L
LL
L
A
T
V
L
L
V
G
F
V
V
T
WL
W
APET
K
A
L
P
L
VAA
G
NV
fig|585055.8.peg.3083
Escherichia coli 55989 (9-435/445)
DDLPL
N
RFH
C
RI
AALT
F
G
AH
L
T
DGYVL
GV
IG
Y
A
I
I
QLTPA
MQ
L
TP
F
MA
G
MI
G
GSA
L
L
GLF
L
GSL
VL
G
W
ISD
HI
GR
Q
K
I
F
T
F
S
F
L
L
I
T
L
AS
FLQF
F
A
TT
P
EH
LI
GL
R
I
LIGIG
L
G
G
DY
S
VG
H
T
LL
A
EFSP
R
R
H
RG
ILLGAFS
--------
VV
W
T
VG
YVL
AS
I
A
G
H
HFISENPEA
WRW
L
L
A
SAA
L
P
A
LLI
TLL
RW
GT
--------------------
PESPRWLLR
Q
GR
F
AEA
H
AI
V
H
R
Y
FG
PH
V
LLGD
E
V
VTA
T
H
K
H
I
K
-----
--
--------------
T
LF
SS
R
YW
RRT
A
F
NSVFFV
C
L
--
VIP
W
F
V
IYTW
L
PTI
AQTI
GL
-
-
-
E
D
A
LTA
S
LMLN
A
LL
I
V
GA
-----
L
LG
L
V
LT
H
LLA
H
R
KF
L
L
GS
F
LL
L
AAT
L
V
V
MA
C
L
PS
-
G
SS
--------
L
T
LL
L
F
V
-
L
F
ST
T
I
SA
VS
NL
VG
I
L
P
A
E
S
FPTDIR
SL
GVGF
AT
A
M
SR
L
GA
A
VST
GL
LP
W
------
V
L
A
Q
W
G
-
M
Q
VT
L
LL
L
A
T
V
L
L
V
G
F
V
V
T
WL
W
APET
K
A
L
P
L
VAA
G
NV
fig|331111.12.peg.3352
Escherichia coli E24377A (9-435/445)
DDLPL
N
RFH
C
RI
AALT
F
G
AH
L
T
DGYVL
GV
IG
Y
A
I
I
QLTPA
MQ
L
TP
F
MA
G
MI
G
GSA
L
L
GLF
L
GSL
VL
G
W
ISD
HI
GR
Q
K
I
F
T
F
S
F
L
L
I
T
L
AS
FLQF
F
A
TT
P
EH
LI
GL
R
I
LIGIG
L
G
G
DY
S
VG
H
T
LL
A
EFSP
R
R
H
RG
ILLGAFS
--------
VV
W
T
VG
YVL
AS
I
A
G
H
HFISENPEA
WRW
L
L
A
SAA
L
P
A
LLI
TLL
RW
GT
--------------------
PESPRWLLR
Q
GR
F
AEA
H
AI
V
H
R
Y
FG
PH
V
LLGD
E
V
VTA
T
H
K
H
I
K
-----
--
--------------
T
LF
SS
R
YW
RRT
A
F
NSVFFV
C
L
--
VIP
W
F
V
IYTW
L
PTI
AQTI
GL
-
-
-
E
D
A
LTA
S
LMLN
A
LL
I
V
GA
-----
L
LG
L
V
LT
H
LLA
H
R
KF
L
L
GS
F
LL
L
AAT
L
V
V
MA
C
L
PS
-
G
SS
--------
L
T
LL
L
F
V
-
L
F
ST
T
I
SA
VS
NL
VG
I
L
P
A
E
S
FPTDIR
SL
GVGF
AT
A
M
SR
L
GA
A
VST
GL
LP
W
------
V
L
A
Q
W
G
-
M
Q
VT
L
LL
L
A
T
V
L
L
V
G
F
V
V
T
WL
W
APET
K
A
L
P
L
VAA
G
NV
fig|316401.4.peg.3354
Escherichia coli ETEC H10407 (9-435/445)
DDLPL
N
RFH
C
RI
AALT
F
G
AH
L
T
DGYVL
GV
IG
Y
A
I
I
QLTPA
MQ
L
TP
F
MA
G
MI
G
GSA
L
L
GLF
L
GSL
VL
G
W
ISD
HI
GR
Q
K
I
F
T
F
S
F
L
L
I
T
L
AS
FLQF
F
A
TT
P
EH
LI
GL
R
I
LIGIG
L
G
G
DY
S
VG
H
T
LL
A
EFSP
R
R
H
RG
ILLGAFS
--------
VV
W
T
VG
YVL
AS
I
A
G
H
HFISENPEA
WRW
L
L
A
SAA
L
P
A
LLI
TLL
RW
GT
--------------------
PESPRWLLR
Q
GR
F
AEA
H
AI
V
H
R
Y
FG
PH
V
LLGD
E
V
VTA
T
H
K
H
I
K
-----
--
--------------
T
LF
SS
R
YW
RRT
A
F
NSVFFV
C
L
--
VIP
W
F
V
IYTW
L
PTI
AQTI
GL
-
-
-
E
D
A
LTA
S
LMLN
A
LL
I
V
GA
-----
L
LG
L
V
LT
H
LLA
H
R
KF
L
L
GS
F
LL
L
AAT
L
V
V
MA
C
L
PS
-
G
SS
--------
L
T
LL
L
F
V
-
L
F
ST
T
I
SA
VS
NL
VG
I
L
P
A
E
S
FPTDIR
SL
GVGF
AT
A
M
SR
L
GA
A
VST
GL
LP
W
------
V
L
A
Q
W
G
-
M
Q
VT
L
LL
L
A
T
V
L
L
V
G
F
V
V
T
WL
W
APET
K
A
L
P
L
VAA
G
NV
fig|585034.4.peg.2828
Escherichia coli IAI1 (9-435/445)
DDLPL
N
RFH
C
RI
AALT
F
G
AH
L
T
DGYVL
GV
IG
Y
A
I
I
QLTPA
MQ
L
TP
F
MA
G
MI
G
GSA
L
L
GLF
L
GSL
VL
G
W
ISD
HI
GR
Q
K
I
F
T
F
S
F
L
L
I
T
L
AS
FLQF
F
A
TT
P
EH
LI
GL
R
I
LIGIG
L
G
G
DY
S
VG
H
T
LL
A
EFSP
R
R
H
RG
ILLGAFS
--------
VV
W
T
VG
YVL
AS
I
A
G
H
HFISENPEA
WRW
L
L
A
SAA
L
P
A
LLI
TLL
RW
GT
--------------------
PESPRWLLR
Q
GR
F
AEA
H
AI
V
H
R
Y
FG
PH
V
LLGD
E
V
VTA
T
H
K
H
I
K
-----
--
--------------
T
LF
SS
R
YW
RRT
A
F
NSVFFV
C
L
--
VIP
W
F
V
IYTW
L
PTI
AQTI
GL
-
-
-
E
D
A
LTA
S
LMLN
A
LL
I
V
GA
-----
L
LG
L
V
LT
H
LLA
H
R
KF
L
L
GS
F
LL
L
AAT
L
V
V
MA
C
L
PS
-
G
SS
--------
L
T
LL
L
F
V
-
L
F
ST
T
I
SA
VS
NL
VG
I
L
P
A
E
S
FPTDIR
SL
GVGF
AT
A
M
SR
L
GA
A
VST
GL
LP
W
------
V
L
A
Q
W
G
-
M
Q
VT
L
LL
L
A
T
V
L
L
V
G
F
V
V
T
WL
W
APET
K
A
L
P
L
VAA
G
NV
fig|585034.5.peg.2825
Escherichia coli IAI1 (9-435/445)
DDLPL
N
RFH
C
RI
AALT
F
G
AH
L
T
DGYVL
GV
IG
Y
A
I
I
QLTPA
MQ
L
TP
F
MA
G
MI
G
GSA
L
L
GLF
L
GSL
VL
G
W
ISD
HI
GR
Q
K
I
F
T
F
S
F
L
L
I
T
L
AS
FLQF
F
A
TT
P
EH
LI
GL
R
I
LIGIG
L
G
G
DY
S
VG
H
T
LL
A
EFSP
R
R
H
RG
ILLGAFS
--------
VV
W
T
VG
YVL
AS
I
A
G
H
HFISENPEA
WRW
L
L
A
SAA
L
P
A
LLI
TLL
RW
GT
--------------------
PESPRWLLR
Q
GR
F
AEA
H
AI
V
H
R
Y
FG
PH
V
LLGD
E
V
VTA
T
H
K
H
I
K
-----
--
--------------
T
LF
SS
R
YW
RRT
A
F
NSVFFV
C
L
--
VIP
W
F
V
IYTW
L
PTI
AQTI
GL
-
-
-
E
D
A
LTA
S
LMLN
A
LL
I
V
GA
-----
L
LG
L
V
LT
H
LLA
H
R
KF
L
L
GS
F
LL
L
AAT
L
V
V
MA
C
L
PS
-
G
SS
--------
L
T
LL
L
F
V
-
L
F
ST
T
I
SA
VS
NL
VG
I
L
P
A
E
S
FPTDIR
SL
GVGF
AT
A
M
SR
L
GA
A
VST
GL
LP
W
------
V
L
A
Q
W
G
-
M
Q
VT
L
LL
L
A
T
V
L
L
V
G
F
V
V
T
WL
W
APET
K
A
L
P
L
VAA
G
NV
fig|679207.4.peg.822
Escherichia coli MS 107-1 (9-435/445)
DDLPL
N
RFH
C
RI
AALT
F
G
AH
L
T
DGYVL
GV
IG
Y
A
I
I
QLTPA
MQ
L
TP
F
MA
G
MI
G
GSA
L
L
GLF
L
GSL
VL
G
W
ISD
HI
GR
Q
K
I
F
T
F
S
F
L
L
I
T
L
AS
FLQF
F
A
TT
P
EH
LI
GL
R
I
LIGIG
L
G
G
DY
S
VG
H
T
LL
A
EFSP
R
R
H
RG
ILLGAFS
--------
VV
W
T
VG
YVL
AS
I
A
G
H
HFISENPEA
WRW
L
L
A
SAA
L
P
A
LLI
TLL
RW
GT
--------------------
PESPRWLLR
Q
GR
F
AEA
H
AI
V
H
R
Y
FG
PH
V
LLGD
E
V
VTA
T
H
K
H
I
K
-----
--
--------------
T
LF
SS
R
YW
RRT
A
F
NSVFFV
C
L
--
VIP
W
F
V
IYTW
L
PTI
AQTI
GL
-
-
-
E
D
A
LTA
S
LMLN
A
LL
I
V
GA
-----
L
LG
L
V
LT
H
LLA
H
R
KF
L
L
GS
F
LL
L
AAT
L
V
V
MA
C
L
PS
-
G
SS
--------
L
T
LL
L
F
V
-
L
F
ST
T
I
SA
VS
NL
VG
I
L
P
A
E
S
FPTDIR
SL
GVGF
AT
A
M
SR
L
GA
A
VST
GL
LP
W
------
V
L
A
Q
W
G
-
M
Q
VT
L
LL
L
A
T
V
L
L
V
G
F
V
V
T
WL
W
APET
K
A
L
P
L
VAA
G
NV
fig|679205.4.peg.3018
Escherichia coli MS 124-1 (9-435/445)
DDLPL
N
RFH
C
RI
AALT
F
G
AH
L
T
DGYVL
GV
IG
Y
A
I
I
QLTPA
MQ
L
TP
F
MA
G
MI
G
GSA
L
L
GLF
L
GSL
VL
G
W
ISD
HI
GR
Q
K
I
F
T
F
S
F
L
L
I
T
L
AS
FLQF
F
A
TT
P
EH
LI
GL
R
I
LIGIG
L
G
G
DY
S
VG
H
T
LL
A
EFSP
R
R
H
RG
ILLGAFS
--------
VV
W
T
VG
YVL
AS
I
A
G
H
HFISENPEA
WRW
L
L
A
SAA
L
P
A
LLI
TLL
RW
GT
--------------------
PESPRWLLR
Q
GR
F
AEA
H
AI
V
H
R
Y
FG
PH
V
LLGD
E
V
VTA
T
H
K
H
I
K
-----
--
--------------
T
LF
SS
R
YW
RRT
A
F
NSVFFV
C
L
--
VIP
W
F
V
IYTW
L
PTI
AQTI
GL
-
-
-
E
D
A
LTA
S
LMLN
A
LL
I
V
GA
-----
L
LG
L
V
LT
H
LLA
H
R
KF
L
L
GS
F
LL
L
AAT
L
V
V
MA
C
L
PS
-
G
SS
--------
L
T
LL
L
F
V
-
L
F
ST
T
I
SA
VS
NL
VG
I
L
P
A
E
S
FPTDIR
SL
GVGF
AT
A
M
SR
L
GA
A
VST
GL
LP
W
------
V
L
A
Q
W
G
-
M
Q
VT
L
LL
L
A
T
V
L
L
V
G
F
V
V
T
WL
W
APET
K
A
L
P
L
VAA
G
NV
fig|749540.3.peg.22
Escherichia coli MS 146-1 (9-435/445)
DDLPL
N
RFH
C
RI
AALT
F
G
AH
L
T
DGYVL
GV
IG
Y
A
I
I
QLTPA
MQ
L
TP
F
MA
G
MI
G
GSA
L
L
GLF
L
GSL
VL
G
W
ISD
HI
GR
Q
K
I
F
T
F
S
F
L
L
I
T
L
AS
FLQF
F
A
TT
P
EH
LI
GL
R
I
LIGIG
L
G
G
DY
S
VG
H
T
LL
A
EFSP
R
R
H
RG
ILLGAFS
--------
VV
W
T
VG
YVL
AS
I
A
G
H
HFISENPEA
WRW
L
L
A
SAA
L
P
A
LLI
TLL
RW
GT
--------------------
PESPRWLLR
Q
GR
F
AEA
H
AI
V
H
R
Y
FG
PH
V
LLGD
E
V
VTA
T
H
K
H
I
K
-----
--
--------------
T
LF
SS
R
YW
RRT
A
F
NSVFFV
C
L
--
VIP
W
F
V
IYTW
L
PTI
AQTI
GL
-
-
-
E
D
A
LTA
S
LMLN
A
LL
I
V
GA
-----
L
LG
L
V
LT
H
LLA
H
R
KF
L
L
GS
F
LL
L
AAT
L
V
V
MA
C
L
PS
-
G
SS
--------
L
T
LL
L
F
V
-
L
F
ST
T
I
SA
VS
NL
VG
I
L
P
A
E
S
FPTDIR
SL
GVGF
AT
A
M
SR
L
GA
A
VST
GL
LP
W
------
V
L
A
Q
W
G
-
M
Q
VT
L
LL
L
A
T
V
L
L
V
G
F
V
V
T
WL
W
APET
K
A
L
P
L
VAA
G
NV
fig|749547.3.peg.3339
Escherichia coli MS 187-1 (9-435/445)
DDLPL
N
RFH
C
RI
AALT
F
G
AH
L
T
DGYVL
GV
IG
Y
A
I
I
QLTPA
MQ
L
TP
F
MA
G
MI
G
GSA
L
L
GLF
L
GSL
VL
G
W
ISD
HI
GR
Q
K
I
F
T
F
S
F
L
L
I
T
L
AS
FLQF
F
A
TT
P
EH
LI
GL
R
I
LIGIG
L
G
G
DY
S
VG
H
T
LL
A
EFSP
R
R
H
RG
ILLGAFS
--------
VV
W
T
VG
YVL
AS
I
A
G
H
HFISENPEA
WRW
L
L
A
SAA
L
P
A
LLI
TLL
RW
GT
--------------------
PESPRWLLR
Q
GR
F
AEA
H
AI
V
H
R
Y
FG
PH
V
LLGD
E
V
VTA
T
H
K
H
I
K
-----
--
--------------
T
LF
SS
R
YW
RRT
A
F
NSVFFV
C
L
--
VIP
W
F
V
IYTW
L
PTI
AQTI
GL
-
-
-
E
D
A
LTA
S
LMLN
A
LL
I
V
GA
-----
L
LG
L
V
LT
H
LLA
H
R
KF
L
L
GS
F
LL
L
AAT
L
V
V
MA
C
L
PS
-
G
SS
--------
L
T
LL
L
F
V
-
L
F
ST
T
I
SA
VS
NL
VG
I
L
P
A
E
S
FPTDIR
SL
GVGF
AT
A
M
SR
L
GA
A
VST
GL
LP
W
------
V
L
A
Q
W
G
-
M
Q
VT
L
LL
L
A
T
V
L
L
V
G
F
V
V
T
WL
W
APET
K
A
L
P
L
VAA
G
NV
fig|749548.3.peg.917
Escherichia coli MS 196-1 (9-435/445)
DDLPL
N
RFH
C
RI
AALT
F
G
AH
L
T
DGYVL
GV
IG
Y
A
I
I
QLTPA
MQ
L
TP
F
MA
G
MI
G
GSA
L
L
GLF
L
GSL
VL
G
W
ISD
HI
GR
Q
K
I
F
T
F
S
F
L
L
I
T
L
AS
FLQF
F
A
TT
P
EH
LI
GL
R
I
LIGIG
L
G
G
DY
S
VG
H
T
LL
A
EFSP
R
R
H
RG
ILLGAFS
--------
VV
W
T
VG
YVL
AS
I
A
G
H
HFISENPEA
WRW
L
L
A
SAA
L
P
A
LLI
TLL
RW
GT
--------------------
PESPRWLLR
Q
GR
F
AEA
H
AI
V
H
R
Y
FG
PH
V
LLGD
E
V
VTA
T
H
K
H
I
K
-----
--
--------------
T
LF
SS
R
YW
RRT
A
F
NSVFFV
C
L
--
VIP
W
F
V
IYTW
L
PTI
AQTI
GL
-
-
-
E
D
A
LTA
S
LMLN
A
LL
I
V
GA
-----
L
LG
L
V
LT
H
LLA
H
R
KF
L
L
GS
F
LL
L
AAT
L
V
V
MA
C
L
PS
-
G
SS
--------
L
T
LL
L
F
V
-
L
F
ST
T
I
SA
VS
NL
VG
I
L
P
A
E
S
FPTDIR
SL
GVGF
AT
A
M
SR
L
GA
A
VST
GL
LP
W
------
V
L
A
Q
W
G
-
M
Q
VT
L
LL
L
A
T
V
L
L
V
G
F
V
V
T
WL
W
APET
K
A
L
P
L
VAA
G
NV
fig|749532.3.peg.1112
Escherichia coli MS 78-1 (9-435/445)
DDLPL
N
RFH
C
RI
AALT
F
G
AH
L
T
DGYVL
GV
IG
Y
A
I
I
QLTPA
MQ
L
TP
F
MA
G
MI
G
GSA
L
L
GLF
L
GSL
VL
G
W
ISD
HI
GR
Q
K
I
F
T
F
S
F
L
L
I
T
L
AS
FLQF
F
A
TT
P
EH
LI
GL
R
I
LIGIG
L
G
G
DY
S
VG
H
T
LL
A
EFSP
R
R
H
RG
ILLGAFS
--------
VV
W
T
VG
YVL
AS
I
A
G
H
HFISENPEA
WRW
L
L
A
SAA
L
P
A
LLI
TLL
RW
GT
--------------------
PESPRWLLR
Q
GR
F
AEA
H
AI
V
H
R
Y
FG
PH
V
LLGD
E
V
VTA
T
H
K
H
I
K
-----
--
--------------
T
LF
SS
R
YW
RRT
A
F
NSVFFV
C
L
--
VIP
W
F
V
IYTW
L
PTI
AQTI
GL
-
-
-
E
D
A
LTA
S
LMLN
A
LL
I
V
GA
-----
L
LG
L
V
LT
H
LLA
H
R
KF
L
L
GS
F
LL
L
AAT
L
V
V
MA
C
L
PS
-
G
SS
--------
L
T
LL
L
F
V
-
L
F
ST
T
I
SA
VS
NL
VG
I
L
P
A
E
S
FPTDIR
SL
GVGF
AT
A
M
SR
L
GA
A
VST
GL
LP
W
------
V
L
A
Q
W
G
-
M
Q
VT
L
LL
L
A
T
V
L
L
V
G
F
V
V
T
WL
W
APET
K
A
L
P
L
VAA
G
NV
fig|749533.3.peg.4135
Escherichia coli MS 84-1 (9-435/445)
DDLPL
N
RFH
C
RI
AALT
F
G
AH
L
T
DGYVL
GV
IG
Y
A
I
I
QLTPA
MQ
L
TP
F
MA
G
MI
G
GSA
L
L
GLF
L
GSL
VL
G
W
ISD
HI
GR
Q
K
I
F
T
F
S
F
L
L
I
T
L
AS
FLQF
F
A
TT
P
EH
LI
GL
R
I
LIGIG
L
G
G
DY
S
VG
H
T
LL
A
EFSP
R
R
H
RG
ILLGAFS
--------
VV
W
T
VG
YVL
AS
I
A
G
H
HFISENPEA
WRW
L
L
A
SAA
L
P
A
LLI
TLL
RW
GT
--------------------
PESPRWLLR
Q
GR
F
AEA
H
AI
V
H
R
Y
FG
PH
V
LLGD
E
V
VTA
T
H
K
H
I
K
-----
--
--------------
T
LF
SS
R
YW
RRT
A
F
NSVFFV
C
L
--
VIP
W
F
V
IYTW
L
PTI
AQTI
GL
-
-
-
E
D
A
LTA
S
LMLN
A
LL
I
V
GA
-----
L
LG
L
V
LT
H
LLA
H
R
KF
L
L
GS
F
LL
L
AAT
L
V
V
MA
C
L
PS
-
G
SS
--------
L
T
LL
L
F
V
-
L
F
ST
T
I
SA
VS
NL
VG
I
L
P
A
E
S
FPTDIR
SL
GVGF
AT
A
M
SR
L
GA
A
VST
GL
LP
W
------
V
L
A
Q
W
G
-
M
Q
VT
L
LL
L
A
T
V
L
L
V
G
F
V
V
T
WL
W
APET
K
A
L
P
L
VAA
G
NV
fig|566546.3.peg.2932
Escherichia coli W (9-435/445)
DDLPL
N
RFH
C
RI
AALT
F
G
AH
L
T
DGYVL
GV
IG
Y
A
I
I
QLTPA
MQ
L
TP
F
MA
G
MI
G
GSA
L
L
GLF
L
GSL
VL
G
W
ISD
HI
GR
Q
K
I
F
T
F
S
F
L
L
I
T
L
AS
FLQF
F
A
TT
P
EH
LI
GL
R
I
LIGIG
L
G
G
DY
S
VG
H
T
LL
A
EFSP
R
R
H
RG
ILLGAFS
--------
VV
W
T
VG
YVL
AS
I
A
G
H
HFISENPEA
WRW
L
L
A
SAA
L
P
A
LLI
TLL
RW
GT
--------------------
PESPRWLLR
Q
GR
F
AEA
H
AI
V
H
R
Y
FG
PH
V
LLGD
E
V
VTA
T
H
K
H
I
K
-----
--
--------------
T
LF
SS
R
YW
RRT
A
F
NSVFFV
C
L
--
VIP
W
F
V
IYTW
L
PTI
AQTI
GL
-
-
-
E
D
A
LTA
S
LMLN
A
LL
I
V
GA
-----
L
LG
L
V
LT
H
LLA
H
R
KF
L
L
GS
F
LL
L
AAT
L
V
V
MA
C
L
PS
-
G
SS
--------
L
T
LL
L
F
V
-
L
F
ST
T
I
SA
VS
NL
VG
I
L
P
A
E
S
FPTDIR
SL
GVGF
AT
A
M
SR
L
GA
A
VST
GL
LP
W
------
V
L
A
Q
W
G
-
M
Q
VT
L
LL
L
A
T
V
L
L
V
G
F
V
V
T
WL
W
APET
K
A
L
P
L
VAA
G
NV
fig|566546.4.peg.2947
Escherichia coli W (9-435/445)
DDLPL
N
RFH
C
RI
AALT
F
G
AH
L
T
DGYVL
GV
IG
Y
A
I
I
QLTPA
MQ
L
TP
F
MA
G
MI
G
GSA
L
L
GLF
L
GSL
VL
G
W
ISD
HI
GR
Q
K
I
F
T
F
S
F
L
L
I
T
L
AS
FLQF
F
A
TT
P
EH
LI
GL
R
I
LIGIG
L
G
G
DY
S
VG
H
T
LL
A
EFSP
R
R
H
RG
ILLGAFS
--------
VV
W
T
VG
YVL
AS
I
A
G
H
HFISENPEA
WRW
L
L
A
SAA
L
P
A
LLI
TLL
RW
GT
--------------------
PESPRWLLR
Q
GR
F
AEA
H
AI
V
H
R
Y
FG
PH
V
LLGD
E
V
VTA
T
H
K
H
I
K
-----
--
--------------
T
LF
SS
R
YW
RRT
A
F
NSVFFV
C
L
--
VIP
W
F
V
IYTW
L
PTI
AQTI
GL
-
-
-
E
D
A
LTA
S
LMLN
A
LL
I
V
GA
-----
L
LG
L
V
LT
H
LLA
H
R
KF
L
L
GS
F
LL
L
AAT
L
V
V
MA
C
L
PS
-
G
SS
--------
L
T
LL
L
F
V
-
L
F
ST
T
I
SA
VS
NL
VG
I
L
P
A
E
S
FPTDIR
SL
GVGF
AT
A
M
SR
L
GA
A
VST
GL
LP
W
------
V
L
A
Q
W
G
-
M
Q
VT
L
LL
L
A
T
V
L
L
V
G
F
V
V
T
WL
W
APET
K
A
L
P
L
VAA
G
NV
fig|316407.3.peg.2674
Escherichia coli W3110 (9-435/445)
DDLPL
N
RFH
C
RI
AALT
F
G
AH
L
T
DGYVL
GV
IG
Y
A
I
I
QLTPA
MQ
L
TP
F
MA
G
MI
G
GSA
L
L
GLF
L
GSL
VL
G
W
ISD
HI
GR
Q
K
I
F
T
F
S
F
L
L
I
T
L
AS
FLQF
F
A
TT
P
EH
LI
GL
R
I
LIGIG
L
G
G
DY
S
VG
H
T
LL
A
EFSP
R
R
H
RG
ILLGAFS
--------
VV
W
T
VG
YVL
AS
I
A
G
H
HFISENPEA
WRW
L
L
A
SAA
L
P
A
LLI
TLL
RW
GT
--------------------
PESPRWLLR
Q
GR
F
AEA
H
AI
V
H
R
Y
FG
PH
V
LLGD
E
V
VTA
T
H
K
H
I
K
-----
--
--------------
T
LF
SS
R
YW
RRT
A
F
NSVFFV
C
L
--
VIP
W
F
V
IYTW
L
PTI
AQTI
GL
-
-
-
E
D
A
LTA
S
LMLN
A
LL
I
V
GA
-----
L
LG
L
V
LT
H
LLA
H
R
KF
L
L
GS
F
LL
L
AAT
L
V
V
MA
C
L
PS
-
G
SS
--------
L
T
LL
L
F
V
-
L
F
ST
T
I
SA
VS
NL
VG
I
L
P
A
E
S
FPTDIR
SL
GVGF
AT
A
M
SR
L
GA
A
VST
GL
LP
W
------
V
L
A
Q
W
G
-
M
Q
VT
L
LL
L
A
T
V
L
L
V
G
F
V
V
T
WL
W
APET
K
A
L
P
L
VAA
G
NV
fig|316385.7.peg.2962
Escherichia coli str. K-12 substr. DH10B (9-435/445)
DDLPL
N
RFH
C
RI
AALT
F
G
AH
L
T
DGYVL
GV
IG
Y
A
I
I
QLTPA
MQ
L
TP
F
MA
G
MI
G
GSA
L
L
GLF
L
GSL
VL
G
W
ISD
HI
GR
Q
K
I
F
T
F
S
F
L
L
I
T
L
AS
FLQF
F
A
TT
P
EH
LI
GL
R
I
LIGIG
L
G
G
DY
S
VG
H
T
LL
A
EFSP
R
R
H
RG
ILLGAFS
--------
VV
W
T
VG
YVL
AS
I
A
G
H
HFISENPEA
WRW
L
L
A
SAA
L
P
A
LLI
TLL
RW
GT
--------------------
PESPRWLLR
Q
GR
F
AEA
H
AI
V
H
R
Y
FG
PH
V
LLGD
E
V
VTA
T
H
K
H
I
K
-----
--
--------------
T
LF
SS
R
YW
RRT
A
F
NSVFFV
C
L
--
VIP
W
F
V
IYTW
L
PTI
AQTI
GL
-
-
-
E
D
A
LTA
S
LMLN
A
LL
I
V
GA
-----
L
LG
L
V
LT
H
LLA
H
R
KF
L
L
GS
F
LL
L
AAT
L
V
V
MA
C
L
PS
-
G
SS
--------
L
T
LL
L
F
V
-
L
F
ST
T
I
SA
VS
NL
VG
I
L
P
A
E
S
FPTDIR
SL
GVGF
AT
A
M
SR
L
GA
A
VST
GL
LP
W
------
V
L
A
Q
W
G
-
M
Q
VT
L
LL
L
A
T
V
L
L
V
G
F
V
V
T
WL
W
APET
K
A
L
P
L
VAA
G
NV
fig|511145.12.peg.2869
Escherichia coli str. K-12 substr. MG1655 (9-435/445)
DDLPL
N
RFH
C
RI
AALT
F
G
AH
L
T
DGYVL
GV
IG
Y
A
I
I
QLTPA
MQ
L
TP
F
MA
G
MI
G
GSA
L
L
GLF
L
GSL
VL
G
W
ISD
HI
GR
Q
K
I
F
T
F
S
F
L
L
I
T
L
AS
FLQF
F
A
TT
P
EH
LI
GL
R
I
LIGIG
L
G
G
DY
S
VG
H
T
LL
A
EFSP
R
R
H
RG
ILLGAFS
--------
VV
W
T
VG
YVL
AS
I
A
G
H
HFISENPEA
WRW
L
L
A
SAA
L
P
A
LLI
TLL
RW
GT
--------------------
PESPRWLLR
Q
GR
F
AEA
H
AI
V
H
R
Y
FG
PH
V
LLGD
E
V
VTA
T
H
K
H
I
K
-----
--
--------------
T
LF
SS
R
YW
RRT
A
F
NSVFFV
C
L
--
VIP
W
F
V
IYTW
L
PTI
AQTI
GL
-
-
-
E
D
A
LTA
S
LMLN
A
LL
I
V
GA
-----
L
LG
L
V
LT
H
LLA
H
R
KF
L
L
GS
F
LL
L
AAT
L
V
V
MA
C
L
PS
-
G
SS
--------
L
T
LL
L
F
V
-
L
F
ST
T
I
SA
VS
NL
VG
I
L
P
A
E
S
FPTDIR
SL
GVGF
AT
A
M
SR
L
GA
A
VST
GL
LP
W
------
V
L
A
Q
W
G
-
M
Q
VT
L
LL
L
A
T
V
L
L
V
G
F
V
V
T
WL
W
APET
K
A
L
P
L
VAA
G
NV
fig|511145.6.peg.2852
Escherichia coli str. K-12 substr. MG1655 (9-435/445)
DDLPL
N
RFH
C
RI
AALT
F
G
AH
L
T
DGYVL
GV
IG
Y
A
I
I
QLTPA
MQ
L
TP
F
MA
G
MI
G
GSA
L
L
GLF
L
GSL
VL
G
W
ISD
HI
GR
Q
K
I
F
T
F
S
F
L
L
I
T
L
AS
FLQF
F
A
TT
P
EH
LI
GL
R
I
LIGIG
L
G
G
DY
S
VG
H
T
LL
A
EFSP
R
R
H
RG
ILLGAFS
--------
VV
W
T
VG
YVL
AS
I
A
G
H
HFISENPEA
WRW
L
L
A
SAA
L
P
A
LLI
TLL
RW
GT
--------------------
PESPRWLLR
Q
GR
F
AEA
H
AI
V
H
R
Y
FG
PH
V
LLGD
E
V
VTA
T
H
K
H
I
K
-----
--
--------------
T
LF
SS
R
YW
RRT
A
F
NSVFFV
C
L
--
VIP
W
F
V
IYTW
L
PTI
AQTI
GL
-
-
-
E
D
A
LTA
S
LMLN
A
LL
I
V
GA
-----
L
LG
L
V
LT
H
LLA
H
R
KF
L
L
GS
F
LL
L
AAT
L
V
V
MA
C
L
PS
-
G
SS
--------
L
T
LL
L
F
V
-
L
F
ST
T
I
SA
VS
NL
VG
I
L
P
A
E
S
FPTDIR
SL
GVGF
AT
A
M
SR
L
GA
A
VST
GL
LP
W
------
V
L
A
Q
W
G
-
M
Q
VT
L
LL
L
A
T
V
L
L
V
G
F
V
V
T
WL
W
APET
K
A
L
P
L
VAA
G
NV
fig|331112.6.peg.2843
Escherichia coli HS (9-435/445)
DDLPL
N
RFH
C
RI
AALT
F
G
AH
L
T
DGYVL
GV
IG
Y
A
I
I
QLTPA
MQ
L
TP
F
MA
G
MI
G
GSA
L
L
GLF
L
GSL
VL
G
W
ISD
HI
GR
Q
K
I
F
T
F
S
F
L
L
I
T
L
AS
FLQF
F
A
TK
P
EH
LI
GL
R
I
LIGIG
L
G
G
DY
S
VG
H
T
LL
A
EFSP
R
R
H
RG
ILLGAFS
--------
VV
W
T
VG
YVL
AS
I
A
G
H
HFISENPEA
WRW
L
L
A
SAA
L
P
A
LLI
TLL
RW
GT
--------------------
PESPRWLLR
Q
GR
F
AEA
H
AI
V
H
R
Y
FG
PH
V
LLGD
E
V
VTA
T
H
K
H
I
K
-----
--
--------------
T
LF
SS
R
YW
RRT
A
F
NSVFFV
C
L
--
VIP
W
F
V
IYTW
L
PTI
AQTI
GL
-
-
-
E
D
A
LTA
S
LMLN
A
LL
I
V
GA
-----
L
LG
L
V
LT
H
LLA
H
R
KF
L
L
GS
F
LL
L
AAT
L
V
V
MA
C
L
P
A
-
G
SS
--------
L
T
LL
L
F
V
-
L
F
ST
T
I
SA
VS
NL
VG
I
L
P
A
E
S
FPTDIR
SL
GVGF
AT
A
M
SR
L
GA
A
VST
GL
LP
W
------
V
L
A
Q
W
G
-
M
Q
VT
L
LL
L
A
T
V
L
L
V
G
F
V
V
T
WL
W
APET
K
A
L
P
L
VAA
G
NV
fig|701177.3.peg.3438
Escherichia coli O55:H7 str. CB9615 (33-459/469)
DDLPL
N
RFH
C
RI
AALT
F
G
AH
L
T
DGYVL
GV
IG
Y
A
I
I
QLTPA
MQ
L
TP
F
MA
G
MI
G
GSA
H
L
GLF
L
GSL
VL
G
W
ISD
HI
GR
Q
K
I
F
T
F
S
F
L
L
I
T
L
AS
FLQF
F
A
TT
P
EH
LI
GL
R
I
LIGIG
L
G
G
DY
S
VG
H
T
LL
A
EFSP
R
R
H
RG
VLLGAFS
--------
VV
W
T
VG
YVL
AS
I
A
G
H
HFISENPEA
WRW
L
L
A
SAA
L
P
A
LLI
TLL
RW
GT
--------------------
PESPRWLLR
Q
G
C
F
AEA
H
AI
V
H
R
Y
FG
PH
V
LLGD
E
V
ATA
T
H
K
H
I
K
-----
--
--------------
T
LF
SS
R
YW
RRT
A
F
NSVFFV
C
L
--
VIP
W
F
V
IYTW
L
PTI
AQTI
GL
-
-
-
E
D
A
LTA
S
LMLN
A
LL
I
V
GA
-----
L
LG
L
V
LT
H
LLA
H
R
KF
L
L
GS
F
LL
L
AAT
L
V
V
MA
C
L
PS
-
G
SS
--------
L
T
LL
L
F
V
-
L
F
ST
T
I
SA
VS
NL
VG
I
L
P
A
E
S
FPTDIR
SL
GVGF
AT
A
M
SR
L
GA
A
VST
GL
LP
W
------
V
L
A
Q
W
G
-
M
Q
VT
L
LL
L
A
A
V
L
L
A
G
F
V
V
T
WL
W
APET
K
A
L
P
L
VAA
G
NV
fig|585397.7.peg.288
Escherichia coli ED1a (15-464/477)
RI
CAIA
A
L
GG
I
L
F
GY
DT
AV
I
SG
A
I
G
S
LT
S
Y
FH
L
SP
A
EI
G
WA
V
SCV
V
V
G
CV
I
GS
F
SA
GY
L
S
K
RF
GR
K
K
S
L
M
V
S
A
L
L
F
T
IS
A
VGTS
LS
YT
F
TH
F
V
IY
R
I
I
G
G
L
A
V
G
LAA
T
V
S
P
M
YM
S
E
V
SP
K
N
M
RG
RALSMQQ
FAIVFGQI
LI
F
Y
V
N
YKI
AS
I
A
AD
TWLIEL--G
WR
Y
M
F
A
A
GI
IP
C
I
L
F
CIL
V
F
LI
--------------------
PESPRW
MM
MI
GR
E
E
E
TL
KI
L
T
K
I
--
--
-
-SNE
E
H
ARH
L
L
A
D
I
K
-
TS
L
Q
ND
Q
L
N
AHQ
K
-------
L
N
Y
RD
G
NV
R
F
I
L
I
LGCMIA
I
L
QQ
V
TG
V
N
V
M
MY
Y
A
P
I
V
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-T
D
S
A
Q
E
A
LFQ
TI
W
I
GV
IQ
LI
G
S
----
I
I
GA
M
I
MD
K
MGR
LS
LM
R
K
G
T
I
GS
I
IGL
L
LTSW
A
LY
S
Q
A
TG
YF
A
-----
L
FG
M
L
F
F
M
I
F
YA
L
S
W
G
VG
--
AW
V
LI
S
E
I
FP
NR
M
R
SQ
G
M
SI
SV
GFMW
M
AN
F
L
V
S
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F
P
M
INENPY
L
L
S
H
F
H
-
G
A
FP
M
W
I
F
A
I
C
C
I
F
SYFFI
CR
Y
L
PET
K
G
I
SL
EKM
E
S
V
V
L
AK
R
R
fig|585397.9.peg.288
Escherichia coli ED1a (15-464/477)
RI
CAIA
A
L
GG
I
L
F
GY
DT
AV
I
SG
A
I
G
S
LT
S
Y
FH
L
SP
A
EI
G
WA
V
SCV
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V
G
CV
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F
SA
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L
S
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GR
K
K
S
L
M
V
S
A
L
L
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T
IS
A
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TH
F
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R
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G
L
A
V
G
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T
V
S
P
M
YM
S
E
V
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K
N
M
RG
RALSMQQ
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LI
F
Y
V
N
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AS
I
A
AD
TWLIEL--G
WR
Y
M
F
A
A
GI
IP
C
I
L
F
CIL
V
F
LI
--------------------
PESPRW
MM
MI
GR
E
E
E
TL
KI
L
T
K
I
--
--
-
-SNE
E
H
ARH
L
L
A
D
I
K
-
TS
L
Q
ND
Q
L
N
AHQ
K
-------
L
N
Y
RD
G
NV
R
F
I
L
I
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I
L
QQ
V
TG
V
N
V
M
MY
Y
A
P
I
V
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D
S
A
Q
E
A
LFQ
TI
W
I
GV
IQ
LI
G
S
----
I
I
GA
M
I
MD
K
MGR
LS
LM
R
K
G
T
I
GS
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L
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LY
S
Q
A
TG
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-----
L
FG
M
L
F
F
M
I
F
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L
S
W
G
VG
--
AW
V
LI
S
E
I
FP
NR
M
R
SQ
G
M
SI
SV
GFMW
M
AN
F
L
V
S
QF
F
P
M
INENPY
L
L
S
H
F
H
-
G
A
FP
M
W
I
F
A
I
C
C
I
F
SYFFI
CR
Y
L
PET
K
G
I
SL
EKM
E
S
V
V
L
AK
R
R
fig|431946.3.peg.1691
Escherichia coli SE15 (29-474/475)
Q
IGARL
D
R
LPL
A
RFH
Y
RI
FGII
S
F
SL
LL
T
G
FLS
YS
GN
V
V
L
A
K
L
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GW
S
NN
F
LN
A
AF
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M
F
G
Y
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I
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G
F
I
G
D
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R
A
F
R
I
N
L
L
I
V
G
I
A
A
TGAA
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PD
M
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LI
FF
R
F
L
M
G
T
G
M
GA
LI
M
VG
Y
A
SF
TEF
I
P
A
T
V
RG
-------
--------
-K
W
S
AR
---
L
S
F
VG
-
--------N
W
SP
ML
-
SAAI
G
V
VV
I
AFF
S
W
RI
MFLLGGIGILLAWFLSGKYFI
ESPRWL
AG
KGR
I
A
G
AE
SQ
L
R
E
V
--
--
-
----
EQ
QIE
R
E
K
S
IR
LPPLT
LN
QSNSKVKVIKGTFW
L
LF
KG
E
ML
RRTL
V
AITVLI
A
M
--
N
I
S
L
Y
T
I
TV
W
M
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FVNS
G
I
D
V
D
K
-
-
---
S
ILMT
A
VI
M
I
GA
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I
AA
L
I
ID
H
FPR
R
-
--
L
F
GS
A
LL
I
I--
I
AVLG
Y
I
Y
S
I
Q
TT
EWAILIYG
LV
MI
F
F
L
Y
M
Y
VC
F
A
SA
--
--
--
V
Y
I
P
EL
W
PT
HL
R
LR
G
S
GF
VN
A
V
G
RI
V
A
V
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VA
A
------
L
L
T
H
YG
S
I
T
V
F
M
V
LG
V
M
L
V
L
C
A
LV
L
S
-I
F
GI
ETR
K
V
SL
EEI
S
E
V
fig|656417.3.peg.2278
Escherichia coli M605 (6-451/452)
Q
IGARL
D
R
LPL
A
RFH
Y
RI
FGII
S
F
SL
LL
T
G
FLS
YS
GN
V
V
L
A
K
L
VSN
GW
S
NN
F
LN
A
AF
T
SAL
M
F
G
Y
F
I
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TG
G
F
I
G
D
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R
A
F
R
I
N
L
L
I
V
G
I
A
A
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PD
M
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LI
FF
R
F
L
M
G
T
G
M
GA
LI
M
VG
Y
A
SF
TEF
I
P
A
T
V
RG
-------
--------
-K
W
S
AR
---
L
S
F
VG
-
--------N
W
SP
ML
-
SAAI
G
V
VV
I
AFF
S
W
RI
MFLLGGIGILLAWFLSGKYFI
ESPRWL
AG
KGR
I
A
G
AE
SQ
L
R
E
V
--
--
-
----
EQ
QIE
R
E
K
S
IR
LPPLT
LN
QSNSKVKVIKGTFW
L
LF
KG
E
ML
RRTL
V
AITVLI
A
M
--
N
I
S
L
Y
T
I
TV
W
I
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G
I
D
V
D
K
-
-
---
S
ILMT
A
VI
M
I
GA
PVGIF
I
AA
L
I
ID
H
FPR
R
-
--
L
F
GS
A
LL
I
I--
I
AVLG
Y
I
Y
S
I
Q
TT
EWAILIYG
LV
MI
F
F
L
Y
M
Y
VC
F
A
SA
--
--
--
V
Y
I
P
EL
W
PT
HL
R
LR
G
S
GF
VN
A
V
G
RI
V
A
V
FTP
YG
VA
A
------
L
L
T
H
YG
S
I
T
V
F
M
V
LG
V
M
L
V
L
C
A
LV
L
S
-I
F
GI
ETR
K
V
SL
EEI
S
E
V
fig|714962.3.peg.1924
Escherichia coli IHE3034 (29-474/475)
Q
IGARL
D
R
LPL
A
RFH
Y
RI
FGII
S
F
SL
LL
T
G
FLS
YS
GN
V
V
L
A
K
L
VSN
GW
S
NN
F
LN
A
AF
T
SAL
M
F
G
Y
F
I
GSL
TG
G
F
I
G
D
YF
GRR
R
A
F
R
I
N
L
L
I
V
G
I
A
A
TGAA
FV
PD
M
YW
LI
FF
R
F
L
M
G
T
G
M
GA
LI
M
VG
Y
A
SF
TEF
I
P
A
T
V
RG
-------
--------
-K
W
S
AR
---
L
S
F
VG
-
--------N
W
SP
ML
-
SAAI
G
V
VV
I
AFF
S
W
RI
MFLLGGIGILLAWFLSGKYFI
ESPRWL
AG
KG
Q
I
A
G
AE
SQ
L
R
E
V
--
--
-
----
EQ
QIE
R
E
K
R
IR
LPPLT
LN
QSNSKVKVIKGTFW
L
LF
KG
E
ML
RRTL
V
AITVLI
A
M
--
N
I
S
L
Y
T
I
TV
W
I
PTI
FVNS
G
I
D
V
D
K
-
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---
S
ILMT
A
VI
M
I
GA
PVGIF
I
AA
L
I
ID
H
FPR
R
-
--
L
F
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A
LL
I
I--
I
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Y
I
Y
S
I
Q
TT
EWAILIYG
LV
MI
F
F
L
Y
M
Y
VC
F
A
SA
--
--
--
V
Y
I
P
EL
W
PT
HL
R
LR
G
S
GF
VN
A
V
G
RI
V
A
V
FTP
YG
VA
A
------
L
L
T
H
YG
S
I
T
V
F
M
V
LG
V
M
L
V
L
C
A
LV
L
S
-I
F
GI
ETR
K
V
SL
EEI
S
E
V
fig|574521.7.peg.1941
Escherichia coli O127:H6 str. E2348/69 (29-474/475)
Q
IGARL
D
R
LPL
A
RFH
Y
RI
FGII
S
F
SL
LL
T
G
FLS
YS
GN
V
V
L
A
K
L
VSN
GW
S
NN
F
LN
A
AF
T
SAL
M
F
G
Y
F
I
GSL
TG
G
F
I
G
D
YF
GRR
R
A
F
R
I
N
L
L
I
V
G
I
A
A
TGAA
FV
PD
M
YW
LI
FF
R
F
L
M
G
T
G
M
GA
LI
M
VG
Y
A
SF
TEF
I
P
A
T
V
RG
-------
--------
-K
W
S
AR
---
L
S
F
VG
-
--------N
W
SP
ML
-
SAAI
G
V
VV
I
AFF
S
W
RI
MFLLGGIGILLAWFLSGKYFI
ESPRWL
AG
KG
Q
I
A
G
AE
SQ
L
R
E
V
--
--
-
----
EQ
QIE
R
E
K
S
IR
LPPLT
LN
QSNSKVKVIKGTFW
L
LF
KG
E
ML
RRTL
V
AITVLI
A
M
--
N
I
S
L
Y
T
I
TV
W
I
PTI
FVNS
G
I
D
V
D
K
-
-
---
S
ILMT
A
VI
M
I
GA
PVGIF
I
AA
L
I
ID
H
FPR
R
-
--
L
F
GS
A
LL
I
I--
I
AVLG
Y
I
Y
S
I
Q
TT
EWAILIYG
LV
MI
F
F
L
Y
M
Y
VC
F
A
SA
--
--
--
V
Y
I
P
EL
W
PT
HL
R
LR
G
S
GF
VN
A
V
G
RI
V
A
V
FTP
YG
VA
A
------
L
L
T
H
YG
S
I
T
V
F
M
V
LG
V
M
L
V
L
C
A
LV
L
S
-I
F
GI
ETR
K
V
SL
EEI
S
E
V
fig|585035.6.peg.1811
Escherichia coli S88 (29-474/475)
Q
IGARL
D
R
LPL
A
RFH
Y
RI
FGII
S
F
SL
LL
T
G
FLS
YS
GN
V
V
L
A
K
L
VSN
GW
S
NN
F
LN
A
AF
T
SAL
M
F
G
Y
F
I
GSL
TG
G
F
I
G
D
YF
GRR
R
A
F
R
I
N
L
L
I
V
G
I
A
A
TGAA
FV
PD
M
YW
LI
FF
R
F
L
M
G
T
G
M
GA
LI
M
VG
Y
A
SF
TEF
I
P
A
T
V
RG
-------
--------
-K
W
S
AR
---
L
S
F
VG
-
--------N
W
SP
ML
-
SAAI
G
V
VV
I
AFF
S
W
RI
MFLLGGIGILLAWFLSGKYFI
ESPRWL
AG
KG
Q
I
A
G
AE
SQ
L
R
E
V
--
--
-
----
EQ
QIE
R
E
K
R
IR
LPPLT
LN
QSNSKVKVIKGTFW
L
LF
KG
E
ML
RRTL
V
AITVLI
A
M
--
N
I
S
L
Y
T
I
TV
W
I
PTI
FVNS
G
I
D
V
D
K
-
-
---
S
ILMT
A
VI
M
I
GA
PVGIF
I
AA
L
I
ID
H
FPR
R
-
--
L
F
GS
A
LL
I
I--
I
AVLG
Y
I
Y
S
I
Q
TT
EWAILIYG
LV
MI
F
F
L
Y
M
Y
VC
F
A
SA
--
--
--
V
Y
I
P
EL
W
PT
HL
R
LR
G
S
GF
VN
A
V
G
RI
V
A
V
FTP
YG
VA
A
------
L
L
T
H
YG
S
I
T
V
F
M
V
LG
V
M
L
V
L
C
A
LV
L
S
-I
F
GI
ETR
K
V
SL
EEI
S
E
V
fig|364106.7.peg.2003
Escherichia coli UTI89 (29-474/475)
Q
IGARL
D
R
LPL
A
RFH
Y
RI
FGII
S
F
SL
LL
T
G
FLS
YS
GN
V
V
L
A
K
L
VSN
GW
S
NN
F
LN
A
AF
T
SAL
M
F
G
Y
F
I
GSL
TG
G
F
I
G
D
YF
GRR
R
A
F
R
I
N
L
L
I
V
G
I
A
A
TGAA
FV
PD
M
YW
LI
FF
R
F
L
M
G
T
G
M
GA
LI
M
VG
Y
A
SF
TEF
I
P
A
T
V
RG
-------
--------
-K
W
S
AR
---
L
S
F
VG
-
--------N
W
SP
ML
-
SAAI
G
V
VV
I
AFF
S
W
RI
MFLLGGIGILLAWFLSGKYFI
ESPRWL
AG
KG
Q
I
A
G
AE
SQ
L
R
E
V
--
--
-
----
EQ
QIE
R
E
K
R
IR
LPPLT
LN
QSNSKVKVIKGTFW
L
LF
KG
E
ML
RRTL
V
AITVLI
A
M
--
N
I
S
L
Y
T
I
TV
W
I
PTI
FVNS
G
I
D
V
D
K
-
-
---
S
ILMT
A
VI
M
I
GA
PVGIF
I
AA
L
I
ID
H
FPR
R
-
--
L
F
GS
A
LL
I
I--
I
AVLG
Y
I
Y
S
I
Q
TT
EWAILIYG
LV
MI
F
F
L
Y
M
Y
VC
F
A
SA
--
--
--
V
Y
I
P
EL
W
PT
HL
R
LR
G
S
GF
VN
A
V
G
RI
V
A
V
FTP
YG
VA
A
------
L
L
T
H
YG
S
I
T
V
F
M
V
LG
V
M
L
V
L
C
A
LV
L
S
-I
F
GI
ETR
K
V
SL
EEI
S
E
V
fig|364106.8.peg.2006
Escherichia coli UTI89 (29-474/475)
Q
IGARL
D
R
LPL
A
RFH
Y
RI
FGII
S
F
SL
LL
T
G
FLS
YS
GN
V
V
L
A
K
L
VSN
GW
S
NN
F
LN
A
AF
T
SAL
M
F
G
Y
F
I
GSL
TG
G
F
I
G
D
YF
GRR
R
A
F
R
I
N
L
L
I
V
G
I
A
A
TGAA
FV
PD
M
YW
LI
FF
R
F
L
M
G
T
G
M
GA
LI
M
VG
Y
A
SF
TEF
I
P
A
T
V
RG
-------
--------
-K
W
S
AR
---
L
S
F
VG
-
--------N
W
SP
ML
-
SAAI
G
V
VV
I
AFF
S
W
RI
MFLLGGIGILLAWFLSGKYFI
ESPRWL
AG
KG
Q
I
A
G
AE
SQ
L
R
E
V
--
--
-
----
EQ
QIE
R
E
K
R
IR
LPPLT
LN
QSNSKVKVIKGTFW
L
LF
KG
E
ML
RRTL
V
AITVLI
A
M
--
N
I
S
L
Y
T
I
TV
W
I
PTI
FVNS
G
I
D
V
D
K
-
-
---
S
ILMT
A
VI
M
I
GA
PVGIF
I
AA
L
I
ID
H
FPR
R
-
--
L
F
GS
A
LL
I
I--
I
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Y
I
Y
S
I
Q
TT
EWAILIYG
LV
MI
F
F
L
Y
M
Y
VC
F
A
SA
--
--
--
V
Y
I
P
EL
W
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HL
R
LR
G
S
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VN
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V
G
RI
V
A
V
FTP
YG
VA
A
------
L
L
T
H
YG
S
I
T
V
F
M
V
LG
V
M
L
V
L
C
A
LV
L
S
-I
F
GI
ETR
K
V
SL
EEI
S
E
V
fig|585397.7.peg.1996
Escherichia coli ED1a (29-474/475)
Q
IGARL
D
R
LPL
A
RFH
Y
RI
FGII
S
F
SL
LL
T
G
FLS
YS
GN
V
V
L
A
K
L
VSN
GW
S
NN
F
LN
A
AF
T
SAL
M
F
G
Y
F
I
GSL
TG
G
F
I
G
D
YF
GRR
R
A
F
R
I
N
L
L
I
V
G
I
A
A
TGAA
FV
PD
M
YW
LI
FF
R
F
L
M
G
T
G
M
GA
LI
M
VG
Y
A
SF
TEF
I
P
A
T
V
RG
-------
--------
-K
W
S
AR
---
L
S
F
VG
-
--------N
W
SP
I
L
-
SAAI
G
V
VV
I
AFF
S
W
RI
MFLLGGIGILLAWFLSGKYFI
ESPRWL
AG
KG
Q
I
A
G
AE
SQ
L
R
E
V
--
--
-
----
EQ
QIE
R
E
K
R
IR
LPPLT
LN
QSNSKVKVIKGTFW
L
LF
KG
E
ML
RRTL
V
AITVLI
A
M
--
N
I
S
L
Y
T
I
TV
W
I
PTI
FVNS
G
I
D
V
D
K
-
-
---
S
ILMT
A
VI
M
I
GA
PVGIF
I
AA
L
I
ID
H
FPR
R
-
--
L
F
GS
A
LL
I
I--
I
AVLG
Y
I
Y
S
I
Q
TT
EWAILIYG
LV
MI
F
F
L
Y
M
Y
VC
F
A
SA
--
--
--
V
Y
I
P
EL
W
PT
HL
R
LR
G
S
GF
VN
A
V
G
RI
V
A
V
FTP
YG
VA
A
------
L
L
T
Y
YG
S
I
T
V
F
M
V
LG
V
M
L
V
L
C
A
LV
L
S
-I
F
GI
ETR
K
V
SL
EEI
S
E
V
fig|585397.9.peg.1991
Escherichia coli ED1a (29-474/475)
Q
IGARL
D
R
LPL
A
RFH
Y
RI
FGII
S
F
SL
LL
T
G
FLS
YS
GN
V
V
L
A
K
L
VSN
GW
S
NN
F
LN
A
AF
T
SAL
M
F
G
Y
F
I
GSL
TG
G
F
I
G
D
YF
GRR
R
A
F
R
I
N
L
L
I
V
G
I
A
A
TGAA
FV
PD
M
YW
LI
FF
R
F
L
M
G
T
G
M
GA
LI
M
VG
Y
A
SF
TEF
I
P
A
T
V
RG
-------
--------
-K
W
S
AR
---
L
S
F
VG
-
--------N
W
SP
I
L
-
SAAI
G
V
VV
I
AFF
S
W
RI
MFLLGGIGILLAWFLSGKYFI
ESPRWL
AG
KG
Q
I
A
G
AE
SQ
L
R
E
V
--
--
-
----
EQ
QIE
R
E
K
R
IR
LPPLT
LN
QSNSKVKVIKGTFW
L
LF
KG
E
ML
RRTL
V
AITVLI
A
M
--
N
I
S
L
Y
T
I
TV
W
I
PTI
FVNS
G
I
D
V
D
K
-
-
---
S
ILMT
A
VI
M
I
GA
PVGIF
I
AA
L
I
ID
H
FPR
R
-
--
L
F
GS
A
LL
I
I--
I
AVLG
Y
I
Y
S
I
Q
TT
EWAILIYG
LV
MI
F
F
L
Y
M
Y
VC
F
A
SA
--
--
--
V
Y
I
P
EL
W
PT
HL
R
LR
G
S
GF
VN
A
V
G
RI
V
A
V
FTP
YG
VA
A
------
L
L
T
Y
YG
S
I
T
V
F
M
V
LG
V
M
L
V
L
C
A
LV
L
S
-I
F
GI
ETR
K
V
SL
EEI
S
E
V
fig|405955.13.peg.1860
Escherichia coli APEC O1 (29-474/475)
Q
IGARL
D
R
LPL
A
RFH
Y
RI
FGII
S
F
SL
LL
T
G
FLS
YS
GN
V
V
L
A
K
L
VSN
GW
S
NN
F
LN
A
AF
T
SAL
M
F
G
Y
F
I
GSL
TG
G
F
I
G
D
YF
GRR
R
A
F
R
I
N
L
L
I
V
G
I
A
A
TGAA
FV
PD
M
YW
LI
FF
R
F
L
M
G
T
G
M
GA
LI
M
VG
Y
A
SF
TEF
I
P
A
T
V
RG
-------
--------
-K
W
S
AR
---
L
S
F
VG
-
--------N
W
SP
ML
-
SAAI
G
V
VV
I
AFF
S
W
RI
MFLLGGIGILLAWFLSGKYFI
ESPRWL
AG
KG
Q
I
A
G
AE
SQ
L
R
E
A
--
--
-
----
EQ
QIE
R
E
K
R
IR
LPPLT
LN
QSNSKVKVIKGTFW
L
LF
KG
E
ML
RRTL
V
AITVLI
A
M
--
N
I
S
L
Y
T
I
TV
W
I
PTI
FVNS
G
I
D
V
D
K
-
-
---
S
ILMT
A
VI
M
I
GA
PVGIF
I
AA
L
I
ID
H
FPR
R
-
--
L
F
GS
A
LL
I
I--
I
AVLG
Y
I
Y
S
I
Q
TT
EWAILIYG
LV
MI
F
F
L
Y
M
Y
VC
F
A
SA
--
--
--
V
Y
I
P
EL
W
PT
HL
R
LR
G
S
GF
VN
A
V
G
RI
V
A
V
FTP
YG
VA
A
------
L
L
T
H
YG
S
I
T
V
F
M
V
LG
V
M
L
V
L
C
A
LV
L
S
-I
F
GI
ETR
K
V
SL
EEI
S
E
V
fig|405955.9.peg.1520
Escherichia coli APEC O1 (29-474/475)
Q
IGARL
D
R
LPL
A
RFH
Y
RI
FGII
S
F
SL
LL
T
G
FLS
YS
GN
V
V
L
A
K
L
VSN
GW
S
NN
F
LN
A
AF
T
SAL
M
F
G
Y
F
I
GSL
TG
G
F
I
G
D
YF
GRR
R
A
F
R
I
N
L
L
I
V
G
I
A
A
TGAA
FV
PD
M
YW
LI
FF
R
F
L
M
G
T
G
M
GA
LI
M
VG
Y
A
SF
TEF
I
P
A
T
V
RG
-------
--------
-K
W
S
AR
---
L
S
F
VG
-
--------N
W
SP
ML
-
SAAI
G
V
VV
I
AFF
S
W
RI
MFLLGGIGILLAWFLSGKYFI
ESPRWL
AG
KG
Q
I
A
G
AE
SQ
L
R
E
A
--
--
-
----
EQ
QIE
R
E
K
R
IR
LPPLT
LN
QSNSKVKVIKGTFW
L
LF
KG
E
ML
RRTL
V
AITVLI
A
M
--
N
I
S
L
Y
T
I
TV
W
I
PTI
FVNS
G
I
D
V
D
K
-
-
---
S
ILMT
A
VI
M
I
GA
PVGIF
I
AA
L
I
ID
H
FPR
R
-
--
L
F
GS
A
LL
I
I--
I
AVLG
Y
I
Y
S
I
Q
TT
EWAILIYG
LV
MI
F
F
L
Y
M
Y
VC
F
A
SA
--
--
--
V
Y
I
P
EL
W
PT
HL
R
LR
G
S
GF
VN
A
V
G
RI
V
A
V
FTP
YG
VA
A
------
L
L
T
H
YG
S
I
T
V
F
M
V
LG
V
M
L
V
L
C
A
LV
L
S
-I
F
GI
ETR
K
V
SL
EEI
S
E
V
fig|753642.3.peg.3191
Escherichia coli NC101 (6-451/452)
Q
IGARL
D
R
LPL
A
RFH
Y
RI
FGII
S
F
SL
LL
T
G
FLS
YS
GN
V
V
L
A
K
L
VSN
GW
S
NN
F
LN
A
AF
T
SAL
M
F
G
Y
F
I
GSL
TG
G
F
I
G
D
YF
GRR
R
A
F
R
I
N
L
L
I
V
G
I
A
A
TGAA
FV
PD
M
YW
LI
FF
R
F
L
M
G
T
G
M
GA
LI
M
VG
Y
A
SF
TEF
I
P
A
T
V
RG
-------
--------
-K
W
S
AR
---
L
S
F
VG
-
--------N
W
SP
ML
-
SAAI
G
V
VV
I
AFF
S
W
RI
MFLLGGIGILLAWFLSGKYFI
ESPRWL
AG
KG
Q
I
A
G
AE
SQ
L
R
E
V
--
--
-
----
EQ
QIE
R
E
K
R
IR
LPPLT
LN
QSNSKVKVIKGTFW
L
LF
KG
E
ML
RRTL
V
AITVLI
A
M
--
N
I
S
L
Y
T
I
TV
W
I
PTI
FVNS
G
I
D
V
D
K
-
-
---
S
ILMT
A
VI
M
I
GA
PVGIF
I
AA
L
I
ID
H
FPR
R
-
--
L
F
GS
A
LL
I
I--
I
AVLG
Y
I
Y
S
I
Q
TT
EWAILIYG
LV
MI
F
F
L
Y
M
Y
VC
F
A
SA
--
--
--
V
Y
I
P
EL
W
PT
HL
R
LR
G
S
GF
VN
A
V
G
RI
V
A
V
FTP
YG
VA
A
------
L
L
T
H
YG
S
I
T
V
F
M
V
LG
V
M
L
V
L
C
A
LV
L
S
-I
F
GI
ETR
K
V
SL
EEI
S
E
V
fig|656440.3.peg.1691
Escherichia coli TA206 (6-451/452)
Q
IGARL
D
R
LPL
A
RFH
Y
RI
FGII
S
F
SL
LL
T
G
FLS
YS
GN
V
V
L
A
K
L
VSN
GW
S
NN
F
LN
A
AF
T
SAL
M
F
G
Y
F
I
GSL
TG
G
F
I
G
D
YF
GRR
R
A
F
R
I
N
L
L
I
V
G
I
A
A
TGAA
FV
PD
M
YW
LI
FF
R
F
L
M
G
T
G
M
GA
LI
M
VG
Y
A
SF
TEF
I
P
A
T
V
RG
-------
--------
-K
W
S
AR
---
L
S
F
VG
-
--------N
W
SP
ML
-
SAAI
G
V
VV
I
AFF
S
W
RI
MFLLGGIGILLAWFLSGKYFI
ESPRWL
AG
KG
Q
I
A
G
AE
SQ
L
R
E
V
--
--
-
----
EQ
QIE
R
E
K
R
IR
LPPLT
LN
QSNSKVKVIKGTFW
L
LF
KG
E
ML
RRTL
V
AITVLI
A
M
--
N
I
S
L
Y
T
I
TV
W
I
PTI
FVNS
G
I
D
V
D
K
-
-
---
S
ILMT
A
VI
M
I
GA
PVGIF
I
AA
L
I
ID
H
FPR
R
-
--
L
F
GS
A
LL
I
I--
I
AVLG
Y
I
Y
S
I
Q
TT
EWAILIYG
LV
MI
F
F
L
Y
M
Y
VC
F
A
SA
--
--
--
V
Y
I
P
EL
W
PT
HL
R
LR
G
S
GF
VN
A
V
G
RI
V
A
V
FTP
YG
VA
A
------
L
L
T
H
YG
S
I
T
V
F
M
V
LG
V
M
L
V
L
C
A
LV
L
S
-I
F
GI
ETR
K
V
SL
EEI
S
E
V
fig|869729.3.peg.1763
Escherichia coli UM146 (6-451/452)
Q
IGARL
D
R
LPL
A
RFH
Y
RI
FGII
S
F
SL
LL
T
G
FLS
YS
GN
V
V
L
A
K
L
VSN
GW
S
NN
F
LN
A
AF
T
SAL
M
F
G
Y
F
I
GSL
TG
G
F
I
G
D
YF
GRR
R
A
F
R
I
N
L
L
I
V
G
I
A
A
TGAA
FV
PD
M
YW
LI
FF
R
F
L
M
G
T
G
M
GA
LI
M
VG
Y
A
SF
TEF
I
P
A
T
V
RG
-------
--------
-K
W
S
AR
---
L
S
F
VG
-
--------N
W
SP
ML
-
SAAI
G
V
VV
I
AFF
S
W
RI
MFLLGGIGILLAWFLSGKYFI
ESPRWL
AG
KG
Q
I
A
G
AE
SQ
L
R
E
V
--
--
-
----
EQ
QIE
R
E
K
R
IR
LPPLT
LN
QSNSKVKVIKGTFW
L
LF
KG
E
ML
RRTL
V
AITVLI
A
M
--
N
I
S
L
Y
T
I
TV
W
I
PTI
FVNS
G
I
D
V
D
K
-
-
---
S
ILMT
A
VI
M
I
GA
PVGIF
I
AA
L
I
ID
H
FPR
R
-
--
L
F
GS
A
LL
I
I--
I
AVLG
Y
I
Y
S
I
Q
TT
EWAILIYG
LV
MI
F
F
L
Y
M
Y
VC
F
A
SA
--
--
--
V
Y
I
P
EL
W
PT
HL
R
LR
G
S
GF
VN
A
V
G
RI
V
A
V
FTP
YG
VA
A
------
L
L
T
H
YG
S
I
T
V
F
M
V
LG
V
M
L
V
L
C
A
LV
L
S
-I
F
GI
ETR
K
V
SL
EEI
S
E
V
fig|216592.1.peg.1314
Escherichia coli 042 (6-451/452)
Q
IGARL
D
R
LPL
A
RFH
Y
RI
FGII
S
F
SL
LL
T
G
FLS
YS
GN
V
V
L
A
K
L
VSN
GW
S
NN
F
LN
A
AF
T
SAL
M
F
G
Y
F
I
GSL
TG
G
F
I
G
D
YF
GRR
R
A
F
R
I
N
L
L
I
V
G
I
A
A
TGAA
FV
PD
M
YW
LI
FF
R
F
L
M
G
T
G
M
GA
L
F
M
VG
Y
A
SF
TEF
I
P
A
T
V
RG
-------
--------
-K
W
S
AR
---
L
S
F
VG
-
--------N
W
SP
ML
-
SAAI
G
V
VV
I
AFF
S
W
RI
MFLLGGIGILLAWFLSGKYFI
ESPRWL
AG
KG
Q
I
A
G
AE
SQ
L
R
E
V
--
--
-
----
EQ
QIE
R
E
K
S
V
R
LPPLT
LN
H
SNSK
AN
VI
N
GTFW
L
LF
KG
E
ML
RRTL
V
AITVLI
A
M
--
N
I
S
L
Y
T
I
TV
W
I
PTI
FVNS
G
I
D
V
D
K
-
-
---
S
ILMT
A
VI
M
I
GA
PVGIF
I
AA
L
I
ID
H
FPR
R
-
--
L
F
GS
A
LL
I
I--
I
AVLG
Y
I
Y
S
I
Q
TT
EWAILIYG
LV
MI
F
F
L
Y
M
Y
VC
F
A
SA
--
--
--
V
Y
I
P
EL
W
PT
HL
R
LR
G
S
GF
VN
A
V
G
RI
V
A
V
FTP
YG
VA
A
------
L
L
T
H
YG
S
I
T
V
F
M
V
LG
V
M
L
L
L
C
A
LV
L
S
-I
F
GI
ETR
K
V
SL
EDI
S
E
V
fig|216592.3.peg.2012
Escherichia coli 042 (6-451/452)
Q
IGARL
D
R
LPL
A
RFH
Y
RI
FGII
S
F
SL
LL
T
G
FLS
YS
GN
V
V
L
A
K
L
VSN
GW
S
NN
F
LN
A
AF
T
SAL
M
F
G
Y
F
I
GSL
TG
G
F
I
G
D
YF
GRR
R
A
F
R
I
N
L
L
I
V
G
I
A
A
TGAA
FV
PD
M
YW
LI
FF
R
F
L
M
G
T
G
M
GA
L
F
M
VG
Y
A
SF
TEF
I
P
A
T
V
RG
-------
--------
-K
W
S
AR
---
L
S
F
VG
-
--------N
W
SP
ML
-
SAAI
G
V
VV
I
AFF
S
W
RI
MFLLGGIGILLAWFLSGKYFI
ESPRWL
AG
KG
Q
I
A
G
AE
SQ
L
R
E
V
--
--
-
----
EQ
QIE
R
E
K
S
V
R
LPPLT
LN
H
SNSK
AN
VI
N
GTFW
L
LF
KG
E
ML
RRTL
V
AITVLI
A
M
--
N
I
S
L
Y
T
I
TV
W
I
PTI
FVNS
G
I
D
V
D
K
-
-
---
S
ILMT
A
VI
M
I
GA
PVGIF
I
AA
L
I
ID
H
FPR
R
-
--
L
F
GS
A
LL
I
I--
I
AVLG
Y
I
Y
S
I
Q
TT
EWAILIYG
LV
MI
F
F
L
Y
M
Y
VC
F
A
SA
--
--
--
V
Y
I
P
EL
W
PT
HL
R
LR
G
S
GF
VN
A
V
G
RI
V
A
V
FTP
YG
VA
A
------
L
L
T
H
YG
S
I
T
V
F
M
V
LG
V
M
L
L
L
C
A
LV
L
S
-I
F
GI
ETR
K
V
SL
EDI
S
E
V
fig|216593.1.peg.596
Escherichia coli E2348/69 (6-451/452)
Q
IGARL
D
R
LPL
A
RFH
Y
RI
FGII
S
F
SL
LL
T
G
FLS
YS
GN
V
V
L
A
K
L
VSN
GW
S
NN
F
LN
A
AF
T
SAL
M
F
G
Y
F
I
GSL
TG
G
F
I
G
D
YF
GRR
R
A
F
R
I
N
L
L
I
V
G
I
A
A
TGAA
FV
PD
M
YW
LI
FF
R
F
L
M
G
T
G
M
GA
LI
M
VG
Y
A
SF
TEF
I
P
A
T
V
RG
-------
--------
-K
W
S
AR
---
L
S
F
VG
-
--------N
W
SP
ML
-
SAAI
G
V
VV
I
AFF
S
W
RI
MFLLGGIGILLAWFLSGKYFI
ESPRWL
AG
KG
Q
I
A
G
AE
SQ
L
R
E
V
--
--
-
----
EQ
QIE
R
E
K
S
IR
LPPLT
LN
QSNSKVKVIKGTFW
L
LF
KG
E
ML
RRTL
V
AITVLI
A
M
--
N
I
S
L
Y
T
I
TV
W
I
PTI
FVNS
G
I
D
V
D
K
-
-
---
S
ILMT
A
VI
M
I
GA
PVGIF
I
AA
L
I
ID
H
FPR
R
-
--
L
F
GS
A
LL
I
I--
I
AVLG
Y
I
Y
S
I
Q
TT
EWAILIYG
LV
MI
F
F
L
Y
M
Y
VC
F
A
SA
--
--
--
V
Y
I
P
EL
W
PT
HL
R
LR
G
S
GF
VN
A
V
G
RI
V
A
V
FTP
YG
VA
A
------
L
L
T
H
YG
S
I
T
V
F
M
V
LG
V
M
L
V
L
C
A
LV
L
S
-I
F
GI
ETR
K
V
SL
EEI
S
E
V
fig|685038.3.peg.1786
Escherichia coli O83:H1 str. NRG 857C (6-451/452)
Q
IGARL
D
R
LPL
A
RFH
Y
RI
FGII
S
F
SL
LL
T
G
FLS
YS
GN
V
V
L
A
K
L
VSN
GW
S
NN
F
LN
A
AF
T
SAL
M
F
G
Y
F
I
GSL
TG
G
F
I
G
D
YF
GRR
R
A
F
R
I
N
L
L
I
V
G
I
A
A
TGAA
FV
PD
M
YW
LI
FF
R
F
L
M
G
T
G
M
GA
LI
M
VG
Y
A
SF
TEF
I
P
A
T
V
RG
-------
--------
-K
W
S
AR
---
L
S
F
VG
-
--------N
W
SP
ML
-
SAAI
G
V
VV
I
AFF
S
W
RI
MFLLGGIGILLAWFLSGKYFI
ESPRWL
AG
KG
Q
I
A
G
AE
SQ
L
R
E
V
--
--
-
----
EQ
QIE
R
E
K
S
IR
LPPLT
LN
QSNSKVKVIKGTFW
L
LF
KG
E
ML
RRTL
V
AITVLI
A
M
--
N
I
S
L
Y
T
I
TV
W
I
PTI
FVNS
G
I
D
V
D
K
-
-
---
S
ILMT
A
VI
M
I
GA
PVGIF
I
AA
L
I
ID
H
FPR
R
-
--
L
F
GS
A
LL
I
I--
I
AVLG
Y
I
Y
S
I
Q
TT
EWAILIYG
LV
MI
F
F
L
Y
M
Y
VC
F
A
SA
--
--
--
V
Y
I
P
EL
W
PT
HL
R
LR
G
S
GF
VN
A
V
G
RI
V
A
V
FTP
YG
VA
A
------
L
L
T
H
YG
S
I
T
V
F
M
V
LG
V
M
L
V
L
C
A
LV
L
S
-I
F
GI
ETR
K
V
SL
EEI
S
E
V
fig|439855.10.peg.1580
Escherichia coli SMS-3-5 (6-451/452)
Q
IGARL
D
R
LPL
A
RFH
Y
RI
FGII
S
F
SL
LL
T
G
FLS
YS
GN
V
V
L
A
K
L
VSN
GW
S
NN
F
LN
A
AF
T
SAL
M
F
G
Y
F
I
GSL
TG
G
F
I
G
D
YF
GRR
R
A
F
R
I
N
L
L
I
V
G
I
A
A
TGAA
FV
PD
M
YW
LI
FF
R
F
L
M
G
T
G
M
GA
LI
M
VG
Y
A
SF
TEF
I
P
A
T
V
RG
-------
--------
-K
W
S
AR
---
L
S
F
VG
-
--------N
W
SP
ML
-
SAAI
G
V
VV
I
AFF
S
W
RI
MFLLGGIGILLAWFLSGKYFI
ESPRWL
AG
KG
Q
I
A
G
AE
SQ
L
R
E
V
--
--
-
----
EQ
QIE
R
E
K
S
IR
LPPLT
LN
QSNSKVKVIKGTFW
L
LF
KG
E
ML
RRTL
V
AITVLI
A
M
--
N
I
S
L
Y
T
I
TV
W
I
PTI
FVNS
G
I
D
V
D
K
-
-
---
S
ILMT
A
VI
M
I
GA
PVGIF
I
AA
L
I
ID
H
FPR
R
-
--
L
F
GS
A
LL
I
I--
I
AVLG
Y
I
Y
S
I
Q
TT
EWAILIYG
LV
MI
F
F
L
Y
M
Y
VC
F
A
SA
--
--
--
V
Y
I
P
EL
W
PT
HL
R
LR
G
S
GF
VN
A
V
G
RI
V
A
V
FTP
YG
VA
A
------
L
L
T
H
YG
S
I
T
V
F
M
V
LG
V
M
L
V
L
C
A
LV
L
S
-I
F
GI
ETR
K
V
SL
EEI
S
E
V
fig|749527.3.peg.3660
Escherichia coli MS 21-1 (6-451/452)
Q
IGARL
D
R
LPL
A
RFH
Y
RI
FGII
S
F
SL
LL
T
G
FLS
YS
GN
V
V
L
A
K
L
VSN
GW
S
NN
F
LN
A
AF
T
SAL
M
F
G
Y
F
I
GSL
TG
G
F
I
G
D
YF
GRR
R
A
F
R
I
N
L
L
I
V
G
I
A
A
TGAA
FV
PD
M
YW
LI
FF
R
F
L
M
G
T
G
M
GA
LI
M
VG
Y
A
SF
TEF
I
P
A
T
V
RG
-------
--------
-K
W
S
AR
---
L
S
F
VG
-
--------N
W
SP
ML
-
SAAI
G
V
VV
I
AFF
S
W
RI
MFLLGGIGILLAWFLSGKYFI
ESPRWL
AG
KG
Q
I
A
G
AE
SQ
L
R
E
V
--
--
-
----
EQ
QIE
R
E
K
S
V
R
LPPLT
LN
QSNSK
ANI
I
N
GTFW
L
LF
KG
E
ML
RRTL
V
AITVLI
A
M
--
N
I
S
L
Y
T
I
TV
W
I
PTI
FVNS
G
I
D
V
D
K
-
-
---
S
ILMT
A
VI
M
I
GA
PVGIF
I
AA
L
I
ID
H
FPR
R
-
--
L
F
GS
A
LL
I
I--
I
AVLG
Y
I
Y
S
I
Q
TT
EWA
V
LIYG
LV
MI
F
F
L
Y
M
Y
VC
F
A
SA
--
--
--
V
Y
I
P
EL
W
PT
HL
R
LR
G
S
GF
VN
A
V
G
RI
V
A
V
FTP
YG
VA
A
------
L
L
T
H
YG
S
I
T
V
F
M
V
LG
V
M
L
V
L
C
A
LV
L
S
-I
F
GI
ETR
K
V
SL
EEI
S
E
V
fig|525281.3.peg.729
Escherichia coli 83972 (29-474/475)
Q
IGARL
D
R
LPL
A
RFH
Y
RI
FGII
S
F
SL
LL
T
G
FLS
YS
GN
V
V
L
A
K
L
VSN
GW
S
NN
F
LN
A
AF
T
SAL
M
F
G
Y
F
I
GSL
TG
G
F
I
G
D
YF
GRR
R
A
F
R
I
N
L
L
I
V
G
I
A
A
TGAA
FV
PD
M
HW
LI
FF
R
F
L
M
G
T
G
M
GA
LI
M
VG
Y
A
SF
TEF
I
P
A
T
V
RG
-------
--------
-K
W
S
AR
---
L
S
F
VG
-
--------N
W
SP
ML
-
SAAI
G
V
VV
I
AFF
S
W
RI
MFLLGGIGILLAWFLSGKYFI
ESPRWL
AG
KG
Q
I
A
G
AE
SQ
L
R
E
V
--
--
-
----
EQ
QIE
R
E
K
S
IR
LPPLT
LN
QSNSKVKVIKGTFW
L
LF
KG
E
ML
RRTL
V
AITVLI
A
M
--
N
I
S
L
Y
T
I
TV
W
I
PTI
FVNS
G
I
D
V
D
K
-
-
---
S
ILMT
A
VI
M
I
GA
PVGIF
I
AA
L
I
ID
H
FPR
R
-
--
L
F
GS
A
LL
I
I--
I
AVLG
Y
I
Y
S
I
Q
TT
EWAILIYG
LV
MI
F
F
L
Y
M
Y
VC
F
A
SA
--
--
--
V
Y
I
P
EL
W
PT
HL
R
LR
G
S
GF
VN
A
V
G
RI
V
A
V
FTP
YG
VA
A
------
L
L
T
H
YG
S
I
T
V
F
M
V
LG
V
M
L
V
L
C
A
LV
L
S
-I
F
GI
ETR
K
V
SL
EEI
S
E
V
fig|199310.1.peg.2110
Escherichia coli CFT073 (29-474/475)
Q
IGARL
D
R
LPL
A
RFH
Y
RI
FGII
S
F
SL
LL
T
G
FLS
YS
GN
V
V
L
A
K
L
VSN
GW
S
NN
F
LN
A
AF
T
SAL
M
F
G
Y
F
I
GSL
TG
G
F
I
G
D
YF
GRR
R
A
F
R
I
N
L
L
I
V
G
I
A
A
TGAA
FV
PD
M
HW
LI
FF
R
F
L
M
G
T
G
M
GA
LI
M
VG
Y
A
SF
TEF
I
P
A
T
V
RG
-------
--------
-K
W
S
AR
---
L
S
F
VG
-
--------N
W
SP
ML
-
SAAI
G
V
VV
I
AFF
S
W
RI
MFLLGGIGILLAWFLSGKYFI
ESPRWL
AG
KG
Q
I
A
G
AE
SQ
L
R
E
V
--
--
-
----
EQ
QIE
R
E
K
S
IR
LPPLT
LN
QSNSKVKVIKGTFW
L
LF
KG
E
ML
RRTL
V
AITVLI
A
M
--
N
I
S
L
Y
T
I
TV
W
I
PTI
FVNS
G
I
D
V
D
K
-
-
---
S
ILMT
A
VI
M
I
GA
PVGIF
I
AA
L
I
ID
H
FPR
R
-
--
L
F
GS
A
LL
I
I--
I
AVLG
Y
I
Y
S
I
Q
TT
EWAILIYG
LV
MI
F
F
L
Y
M
Y
VC
F
A
SA
--
--
--
V
Y
I
P
EL
W
PT
HL
R
LR
G
S
GF
VN
A
V
G
RI
V
A
V
FTP
YG
VA
A
------
L
L
T
H
YG
S
I
T
V
F
M
V
LG
V
M
L
V
L
C
A
LV
L
S
-I
F
GI
ETR
K
V
SL
EEI
S
E
V
fig|199310.4.peg.2036
Escherichia coli CFT073 (29-474/475)
Q
IGARL
D
R
LPL
A
RFH
Y
RI
FGII
S
F
SL
LL
T
G
FLS
YS
GN
V
V
L
A
K
L
VSN
GW
S
NN
F
LN
A
AF
T
SAL
M
F
G
Y
F
I
GSL
TG
G
F
I
G
D
YF
GRR
R
A
F
R
I
N
L
L
I
V
G
I
A
A
TGAA
FV
PD
M
HW
LI
FF
R
F
L
M
G
T
G
M
GA
LI
M
VG
Y
A
SF
TEF
I
P
A
T
V
RG
-------
--------
-K
W
S
AR
---
L
S
F
VG
-
--------N
W
SP
ML
-
SAAI
G
V
VV
I
AFF
S
W
RI
MFLLGGIGILLAWFLSGKYFI
ESPRWL
AG
KG
Q
I
A
G
AE
SQ
L
R
E
V
--
--
-
----
EQ
QIE
R
E
K
S
IR
LPPLT
LN
QSNSKVKVIKGTFW
L
LF
KG
E
ML
RRTL
V
AITVLI
A
M
--
N
I
S
L
Y
T
I
TV
W
I
PTI
FVNS
G
I
D
V
D
K
-
-
---
S
ILMT
A
VI
M
I
GA
PVGIF
I
AA
L
I
ID
H
FPR
R
-
--
L
F
GS
A
LL
I
I--
I
AVLG
Y
I
Y
S
I
Q
TT
EWAILIYG
LV
MI
F
F
L
Y
M
Y
VC
F
A
SA
--
--
--
V
Y
I
P
EL
W
PT
HL
R
LR
G
S
GF
VN
A
V
G
RI
V
A
V
FTP
YG
VA
A
------
L
L
T
H
YG
S
I
T
V
F
M
V
LG
V
M
L
V
L
C
A
LV
L
S
-I
F
GI
ETR
K
V
SL
EEI
S
E
V
fig|749531.3.peg.4679
Escherichia coli MS 69-1 (6-451/452)
Q
IGARL
D
R
LPL
A
RFH
Y
RI
FGII
S
F
SL
LL
T
G
FLS
YS
GN
V
V
L
A
K
L
VSN
GW
S
NN
F
LN
A
AF
T
SAL
M
F
G
Y
F
I
GSL
TG
G
F
I
G
D
YF
GRR
R
A
F
R
I
N
L
L
I
V
G
I
A
A
TGAA
FV
PD
M
YW
LI
FF
R
F
L
M
G
T
G
M
GA
LI
M
VG
Y
A
SF
TEF
I
P
A
T
V
RG
-------
--------
-K
W
S
AR
---
L
S
F
VG
-
--------N
W
SP
ML
-
SAAI
G
V
VV
I
AFF
S
W
RI
MFLLGGI
V
ILLAWFLSGKYFI
ESPRWL
AG
KG
Q
I
A
G
AE
SQ
L
R
E
V
--
--
-
----
EQ
QIE
R
E
K
S
V
R
LPPLT
LN
QSNSK
AN
VI
N
GTFW
L
LF
KG
E
ML
RRTL
V
AITVLI
A
M
--
N
I
S
L
Y
T
I
TV
W
I
PTI
FVNS
G
I
D
V
D
K
-
-
---
S
ILMT
A
VI
M
I
GA
PVGIF
I
AA
L
I
ID
H
FPR
R
-
--
L
F
GS
A
LL
I
I--
I
AVLG
Y
I
Y
S
I
Q
TT
EWAILIYG
LV
MI
F
F
L
Y
M
Y
VC
F
A
SA
--
--
--
V
Y
I
P
EL
W
PT
HL
R
LR
G
S
GF
VN
A
V
G
RI
V
A
V
FTP
YG
VA
A
------
L
L
T
H
YG
S
I
T
V
F
M
V
LG
V
M
L
V
L
C
A
LV
L
S
-I
F
GI
ETR
K
V
SL
EEI
S
E
V
fig|655817.3.peg.2123
Escherichia coli ABU 83972 (6-451/452)
Q
IGARL
D
R
LPL
A
RFH
Y
RI
FGII
S
F
SL
LL
T
G
FLS
YS
GN
V
V
L
A
K
L
VSN
GW
S
NN
F
LN
A
AF
T
SAL
M
F
G
Y
F
I
GSL
TG
G
F
I
G
D
YF
GRR
R
A
F
R
I
N
L
L
I
V
G
I
A
A
TGAA
FV
PD
M
HW
LI
FF
R
F
L
M
G
T
G
M
GA
LI
M
VG
Y
A
SF
TEF
I
P
A
T
V
RG
-------
--------
-K
W
S
AR
---
L
S
F
VG
-
--------N
W
SP
ML
-
SAAI
G
V
VV
I
AFF
S
W
RI
MFLLGGIGILLAWFLSGKYFI
ESPRWL
AG
KG
Q
I
A
G
AE
SQ
L
R
E
V
--
--
-
----
EQ
QIE
R
E
K
S
IR
LPPLT
LN
QSNSKVKVIKGTFW
L
LF
KG
E
ML
RRTL
V
AITVLI
A
M
--
N
I
S
L
Y
T
I
TV
W
I
PTI
FVNS
G
I
D
V
D
K
-
-
---
S
ILMT
A
VI
M
I
GA
PVGIF
I
AA
L
I
ID
H
FPR
R
-
--
L
F
GS
A
LL
I
I--
I
AVLG
Y
I
Y
S
I
Q
TT
EWAILIYG
LV
MI
F
F
L
Y
M
Y
VC
F
A
SA
--
--
--
V
Y
I
P
EL
W
PT
HL
R
LR
G
S
GF
VN
A
V
G
RI
V
A
V
FTP
YG
VA
A
------
L
L
T
H
YG
S
I
T
V
F
M
V
LG
V
M
L
V
L
C
A
LV
L
S
-I
F
GI
ETR
K
V
SL
EEI
S
E
V
fig|749546.3.peg.4437
Escherichia coli MS 185-1 (6-451/452)
Q
IGARL
D
R
LPL
A
RFH
Y
RI
FGII
S
F
SL
LL
T
G
FLS
YS
GN
V
V
L
A
K
L
VSN
GW
S
NN
F
LN
A
AF
T
SAL
M
F
G
Y
F
I
GSL
TG
G
F
I
G
D
YF
GRR
R
A
F
R
I
N
L
L
I
V
G
I
A
A
TGAA
FV
PD
M
HW
LI
FF
R
F
L
M
G
T
G
M
GA
LI
M
VG
Y
A
SF
TEF
I
P
A
T
V
RG
-------
--------
-K
W
S
AR
---
L
S
F
VG
-
--------N
W
SP
ML
-
SAAI
G
V
VV
I
AFF
S
W
RI
MFLLGGIGILLAWFLSGKYFI
ESPRWL
AG
KG
Q
I
A
G
AE
SQ
L
R
E
V
--
--
-
----
EQ
QIE
R
E
K
S
IR
LPPLT
LN
QSNSKVKVIKGTFW
L
LF
KG
E
ML
RRTL
V
AITVLI
A
M
--
N
I
S
L
Y
T
I
TV
W
I
PTI
FVNS
G
I
D
V
D
K
-
-
---
S
ILMT
A
VI
M
I
GA
PVGIF
I
AA
L
I
ID
H
FPR
R
-
--
L
F
GS
A
LL
I
I--
I
AVLG
Y
I
Y
S
I
Q
TT
EWAILIYG
LV
MI
F
F
L
Y
M
Y
VC
F
A
SA
--
--
--
V
Y
I
P
EL
W
PT
HL
R
LR
G
S
GF
VN
A
V
G
RI
V
A
V
FTP
YG
VA
A
------
L
L
T
H
YG
S
I
T
V
F
M
V
LG
V
M
L
V
L
C
A
LV
L
S
-I
F
GI
ETR
K
V
SL
EEI
S
E
V
fig|749528.3.peg.4759
Escherichia coli MS 45-1 (6-451/452)
Q
IGARL
D
R
LPL
A
RFH
Y
RI
FGII
S
F
SL
LL
T
G
FLS
YS
GN
V
V
L
A
K
L
VSN
GW
S
NN
F
LN
A
AF
T
SAL
M
F
G
Y
F
I
GSL
TG
G
F
I
G
D
YF
GRR
R
A
F
R
I
N
L
L
I
V
G
I
A
A
TGAA
FV
PD
M
HW
LI
FF
R
F
L
M
G
T
G
M
GA
LI
M
VG
Y
A
SF
TEF
I
P
A
T
V
RG
-------
--------
-K
W
S
AR
---
L
S
F
VG
-
--------N
W
SP
ML
-
SAAI
G
V
VV
I
AFF
S
W
RI
MFLLGGIGILLAWFLSGKYFI
ESPRWL
AG
KG
Q
I
A
G
AE
SQ
L
R
E
V
--
--
-
----
EQ
QIE
R
E
K
S
IR
LPPLT
LN
QSNSKVKVIKGTFW
L
LF
KG
E
ML
RRTL
V
AITVLI
A
M
--
N
I
S
L
Y
T
I
TV
W
I
PTI
FVNS
G
I
D
V
D
K
-
-
---
S
ILMT
A
VI
M
I
GA
PVGIF
I
AA
L
I
ID
H
FPR
R
-
--
L
F
GS
A
LL
I
I--
I
AVLG
Y
I
Y
S
I
Q
TT
EWAILIYG
LV
MI
F
F
L
Y
M
Y
VC
F
A
SA
--
--
--
V
Y
I
P
EL
W
PT
HL
R
LR
G
S
GF
VN
A
V
G
RI
V
A
V
FTP
YG
VA
A
------
L
L
T
H
YG
S
I
T
V
F
M
V
LG
V
M
L
V
L
C
A
LV
L
S
-I
F
GI
ETR
K
V
SL
EEI
S
E
V
fig|562.376.peg.2343
Escherichia coli WV_060327 (6-451/452)
Q
IGARL
D
R
LPL
A
RFH
Y
RI
FGII
S
F
SL
LL
T
G
FLS
YS
GN
V
V
L
A
K
L
VSN
GW
S
NN
F
LN
A
AF
T
SAL
M
F
G
Y
F
I
GSL
TG
G
F
I
G
D
YF
GRR
R
A
F
R
I
N
L
L
I
V
G
I
A
A
TGAA
FV
PD
M
HW
LI
FF
R
F
L
M
G
T
G
M
GA
LI
M
VG
Y
A
SF
TEF
I
P
A
T
V
RG
-------
--------
-K
W
S
AR
---
L
S
F
VG
-
--------N
W
SP
ML
-
SAAI
G
V
VV
I
AFF
S
W
RI
MFLLGGIGILLAWFLSGKYFI
ESPRWL
AG
KG
Q
I
A
G
AE
SQ
L
R
E
V
--
--
-
----
EQ
QIE
R
E
K
S
IR
LPPLT
LN
QSNSKVKVIKGTFW
L
LF
KG
E
ML
RRTL
V
AITVLI
A
M
--
N
I
S
L
Y
T
I
TV
W
I
PTI
FVNS
G
I
D
V
D
K
-
-
---
S
ILMT
A
VI
M
I
GA
PVGIF
I
AA
L
I
ID
H
FPR
R
-
--
L
F
GS
A
LL
I
I--
I
AVLG
Y
I
Y
S
I
Q
TT
EWAILIYG
LV
MI
F
F
L
Y
M
Y
VC
F
A
SA
--
--
--
V
Y
I
P
EL
W
PT
HL
R
LR
G
S
GF
VN
A
V
G
RI
V
A
V
FTP
YG
VA
A
------
L
L
T
H
YG
S
I
T
V
F
M
V
LG
V
M
L
V
L
C
A
LV
L
S
-I
F
GI
ETR
K
V
SL
EEI
S
E
V
fig|362663.9.peg.1741
Escherichia coli 536 (29-474/475)
Q
IGARL
D
R
LPL
A
RFH
Y
RI
FGII
S
F
SL
LL
T
G
FLS
YS
GN
V
V
L
A
K
L
VSN
GW
S
NN
F
LN
A
AF
T
SAL
M
F
G
Y
F
I
GSL
TG
G
F
I
G
D
YF
GRR
R
A
F
R
I
N
L
L
I
V
G
I
A
A
TGAA
FV
PD
M
YW
LI
FF
R
F
L
M
G
T
G
M
GA
LI
M
VG
Y
A
SF
TEF
I
P
A
T
V
RG
-------
--------
-K
W
S
AR
---
L
S
F
VG
-
--------N
W
SP
ML
-
SAAI
G
V
VV
I
AFF
S
W
RI
MFLLGGIGILLAWFLSGKYFI
ESPRWL
AG
KG
Q
I
A
G
AE
SQ
L
R
E
V
--
--
-
----
EQ
QIE
R
E
K
R
IR
LPPLT
LN
QSNSKVKVIKGTFW
L
LF
KG
G
ML
RRTL
V
AITVLI
A
M
--
N
I
S
L
Y
T
I
TV
W
I
PTI
FVNS
G
I
D
V
D
K
-
-
---
S
ILMT
A
VI
M
I
GA
PVGIF
I
AA
L
I
ID
H
FPR
R
-
--
L
F
GS
A
LL
I
I--
I
AVLG
Y
I
Y
S
I
Q
TT
EWAILIYG
LV
MI
F
F
L
Y
M
Y
VC
F
A
SA
--
--
--
V
Y
I
P
EL
W
PT
HL
R
LR
G
S
GF
VN
A
V
G
RI
V
A
V
FTP
YG
VA
A
------
L
L
T
H
YG
S
I
T
V
F
M
V
LG
V
M
L
V
L
C
A
LV
L
S
-I
F
GI
ETR
K
V
SL
EEI
S
E
V
fig|340197.5.peg.1869
Escherichia coli F11 (29-474/475)
Q
IGARL
D
R
LPL
A
RFH
Y
RI
FGII
S
F
SL
LL
T
G
FLS
YS
GN
V
V
L
A
K
L
VSN
GW
S
NN
F
LN
A
AF
T
SAL
M
F
G
Y
F
I
GSL
TG
G
F
I
G
D
YF
GRR
R
A
F
R
I
N
L
L
I
V
G
I
A
A
TGAA
FV
PD
M
YW
LI
FF
R
F
L
M
G
T
G
M
GA
LI
M
VG
Y
A
SF
TEF
I
P
A
T
V
RG
-------
--------
-K
W
S
AR
---
L
S
F
VG
-
--------N
W
SP
ML
-
SAAI
G
V
VV
I
AFF
S
W
RI
MFLLGGIGILLAWFLSGKYFI
ESPRWL
AG
KG
Q
I
A
G
AE
SQ
L
R
E
V
--
--
-
----
EQ
QIE
R
E
K
R
IR
LPPLT
LN
QSNSKVKVIKGTFW
L
LF
KG
G
ML
RRTL
V
AITVLI
A
M
--
N
I
S
L
Y
T
I
TV
W
I
PTI
FVNS
G
I
D
V
D
K
-
-
---
S
ILMT
A
VI
M
I
GA
PVGIF
I
AA
L
I
ID
H
FPR
R
-
--
L
F
GS
A
LL
I
I--
I
AVLG
Y
I
Y
S
I
Q
TT
EWAILIYG
LV
MI
F
F
L
Y
M
Y
VC
F
A
SA
--
--
--
V
Y
I
P
EL
W
PT
HL
R
LR
G
S
GF
VN
A
V
G
RI
V
A
V
FTP
YG
VA
A
------
L
L
T
H
YG
S
I
T
V
F
M
V
LG
V
M
L
V
L
C
A
LV
L
S
-I
F
GI
ETR
K
V
SL
EEI
S
E
V
fig|566546.3.peg.869
Escherichia coli W (6-451/452)
Q
IGARL
D
R
LPL
A
RFH
Y
RI
FGII
S
F
SL
LL
T
G
FLS
YS
GN
V
V
L
A
K
L
VSN
GW
S
NN
F
LN
A
AF
T
SAL
M
F
G
Y
F
I
GSL
TG
G
F
I
G
D
YF
GRR
R
A
F
R
I
N
L
L
I
V
G
I
A
A
TGAA
FV
PD
M
YW
LI
FF
R
F
L
M
G
T
G
M
GA
LI
M
VG
Y
A
SF
TEF
I
P
A
T
V
RG
-------
--------
-K
W
S
AR
---
L
S
F
VG
-
--------N
W
SP
ML
-
SAAI
G
V
VV
I
AFF
S
W
RI
MFLLGGIGILLAWFLSGKYFI
ESPRWL
AG
KG
Q
I
A
G
AE
SQ
L
R
E
V
--
--
-
----
EQ
QIE
R
E
K
S
IR
LPP
P
T
SY
QSNSKVKVIKGTFW
L
LF
KG
E
ML
RRTL
V
AITVLI
A
M
--
N
I
S
L
Y
T
I
TV
W
I
PTI
FVNS
G
I
D
V
D
K
-
-
---
S
ILMT
A
VI
M
I
GA
PVGIF
I
AA
L
I
ID
H
FPR
R
-
--
L
F
GS
T
LL
I
I--
I
AVLG
Y
I
Y
S
I
Q
TT
EWAILIYG
LV
MI
F
F
L
Y
M
Y
VC
F
A
SA
--
--
--
V
Y
I
P
EL
W
PT
HL
R
LR
G
S
GF
VN
A
V
G
RI
V
A
V
FTP
YG
VA
A
------
L
L
T
H
YG
S
I
T
V
F
M
V
LG
V
M
L
L
L
C
A
LV
L
S
-I
F
GI
ETR
K
V
SL
EEI
S
E
V
fig|340197.3.peg.1772
Escherichia coli F11 (6-451/452)
Q
IGARL
D
R
LPL
A
RFH
Y
RI
FGII
S
F
SL
LL
T
G
FLS
YS
GN
V
V
L
A
K
L
VSN
GW
S
NN
F
LN
A
AF
T
SAL
M
F
G
Y
F
I
GSL
TG
G
F
I
G
D
YF
GRR
R
A
F
R
I
N
L
L
I
V
G
I
A
A
TGAA
FV
PD
M
YW
LI
FF
R
F
L
M
G
T
G
M
GA
LI
M
VG
Y
A
SF
TEF
I
P
A
T
V
RG
-------
--------
-K
W
S
AR
---
L
S
F
VG
-
--------N
W
SP
ML
-
SAAI
G
V
VV
I
AFF
S
W
RI
MFLLGGIGILLAWFLSGKYFI
ESPRWL
AG
KG
Q
I
A
G
AE
SQ
L
R
E
V
--
--
-
----
EQ
QIE
R
E
K
R
IR
LPPLT
LN
QSNSKVKVIKGTFW
L
LF
KG
G
ML
RRTL
V
AITVLI
A
M
--
N
I
S
L
Y
T
I
TV
W
I
PTI
FVNS
G
I
D
V
D
K
-
-
---
S
ILMT
A
VI
M
I
GA
PVGIF
I
AA
L
I
ID
H
FPR
R
-
--
L
F
GS
A
LL
I
I--
I
AVLG
Y
I
Y
S
I
Q
TT
EWAILIYG
LV
MI
F
F
L
Y
M
Y
VC
F
A
SA
--
--
--
V
Y
I
P
EL
W
PT
HL
R
LR
G
S
GF
VN
A
V
G
RI
V
A
V
FTP
YG
VA
A
------
L
L
T
H
YG
S
I
T
V
F
M
V
LG
V
M
L
V
L
C
A
LV
L
S
-I
F
GI
ETR
K
V
SL
EEI
S
E
V
fig|656379.3.peg.2242
Escherichia coli FVEC1302 (6-451/452)
Q
IGARL
D
R
LPL
A
RFH
Y
RI
FGII
S
F
SL
LL
T
G
FLS
YS
GN
V
V
L
A
K
L
VSN
GW
S
NN
F
LN
A
AF
T
SAL
M
F
G
Y
F
I
GSL
TG
G
F
I
G
D
YF
GRR
R
A
F
R
I
N
L
L
I
V
G
I
A
A
TGAA
FV
PD
M
YW
LI
FF
R
F
L
M
G
T
G
M
GA
LI
M
VG
Y
A
SF
TEF
I
P
A
T
V
RG
-------
--------
-K
W
S
AR
---
L
S
F
VG
-
--------N
W
SP
ML
-
SAAI
G
V
VV
I
AFF
S
W
RI
MFLLGGIGILLAWFLSGKYFI
ESPRWL
AG
KG
Q
I
A
G
AE
SQ
L
R
E
V
--
--
-
----
EQ
QIE
R
E
K
S
V
R
LPPLT
LN
QSNSK
AN
VI
N
GTFW
L
LF
KG
E
ML
RRTL
V
AITVLI
A
M
--
N
I
S
L
Y
T
I
TV
W
I
PTI
FVNS
G
I
D
V
D
K
-
-
---
S
ILMT
A
VI
M
I
GA
PVGIF
I
AA
L
I
ID
H
FPR
R
-
--
L
F
GS
A
LL
I
I--
I
AVLG
Y
I
Y
S
I
Q
TT
EWAILIYG
LV
MI
F
F
L
Y
M
Y
VC
F
A
SA
--
--
--
V
Y
I
P
EL
W
PT
HL
R
LR
G
S
GF
VN
A
V
G
RI
V
A
V
FTP
YG
VA
A
------
L
L
T
H
YG
S
I
T
V
F
I
V
LG
V
M
L
V
L
C
A
LV
L
S
-I
F
GI
ETR
K
V
SL
EEI
S
E
V
fig|656380.3.peg.3206
Escherichia coli FVEC1412 (6-451/452)
Q
IGARL
D
R
LPL
A
RFH
Y
RI
FGII
S
F
SL
LL
T
G
FLS
YS
GN
V
V
L
A
K
L
VSN
GW
S
NN
F
LN
A
AF
T
SAL
M
F
G
Y
F
I
GSL
TG
G
F
I
G
D
YF
GRR
R
A
F
R
I
N
L
L
I
V
G
I
A
A
TGAA
FV
PD
M
YW
LI
FF
R
F
L
M
G
T
G
M
GA
LI
M
VG
Y
A
SF
TEF
I
P
A
T
V
RG
-------
--------
-K
W
S
AR
---
L
S
F
VG
-
--------N
W
SP
ML
-
SAAI
G
V
VV
I
AFF
S
W
RI
MFLLGGIGILLAWFLSGKYFI
ESPRWL
AG
KG
Q
I
A
G
AE
SQ
L
R
E
V
--
--
-
----
EQ
QIE
R
E
K
S
V
R
LPPLT
LN
QSNSK
AN
VI
N
GTFW
L
LF
KG
E
ML
RRTL
V
AITVLI
A
M
--
N
I
S
L
Y
T
I
TV
W
I
PTI
FVNS
G
I
D
V
D
K
-
-
---
S
ILMT
A
VI
M
I
GA
PVGIF
I
AA
L
I
ID
H
FPR
R
-
--
L
F
GS
A
LL
I
I--
I
AVLG
Y
I
Y
S
I
Q
TT
EWAILIYG
LV
MI
F
F
L
Y
M
Y
VC
F
A
SA
--
--
--
V
Y
I
P
EL
W
PT
HL
R
LR
G
S
GF
VN
A
V
G
RI
V
A
V
FTP
YG
VA
A
------
L
L
T
H
YG
S
I
T
V
F
I
V
LG
V
M
L
V
L
C
A
LV
L
S
-I
F
GI
ETR
K
V
SL
EEI
S
E
V
fig|749549.3.peg.3036
Escherichia coli MS 198-1 (6-451/452)
Q
IGARL
D
R
LPL
A
RFH
Y
RI
FGII
S
F
SL
LL
T
G
FLS
YS
GN
V
V
L
A
K
L
VSN
GW
S
NN
F
LN
A
AF
T
SAL
M
F
G
Y
F
I
GSL
TG
G
F
I
G
D
YF
GRR
R
A
F
R
I
N
L
L
I
V
G
I
A
A
TGAA
FV
PD
M
YW
LI
FF
R
F
L
M
G
T
G
M
GA
LI
M
VG
Y
A
SF
TEF
I
P
A
T
V
RG
-------
--------
-K
W
S
AR
---
L
S
F
VG
-
--------N
W
SP
ML
-
SAAI
G
V
VV
I
AFF
S
W
RI
MFLLGGIGILLAWFLSGKYFI
ESPRWL
AG
KG
Q
I
A
G
AE
SQ
L
R
E
V
--
--
-
----
EQ
QIE
R
E
K
S
V
R
LPPLT
LN
QSNSK
AN
VI
N
GTFW
L
LF
KG
E
ML
RRTL
V
AITVLI
A
M
--
N
I
S
L
Y
T
I
TV
W
I
PTI
FVNS
G
I
D
V
D
K
-
-
---
S
ILMT
A
VI
M
I
GA
PVGIF
I
AA
L
I
ID
H
FPR
R
-
--
L
F
GS
A
LL
I
I--
I
AVLG
Y
I
Y
S
I
Q
TT
EWAILIYG
LV
MI
F
F
L
Y
M
Y
VC
F
A
SA
--
--
--
V
Y
I
P
EL
W
PT
HL
R
LR
G
S
GF
VN
A
V
G
RI
V
A
V
FTP
YG
VA
A
------
L
L
T
H
YG
S
I
T
V
F
I
V
LG
V
M
L
V
L
C
A
LV
L
S
-I
F
GI
ETR
K
V
SL
EEI
S
E
V
fig|585056.7.peg.2245
Escherichia coli UMN026 (6-451/452)
Q
IGARL
D
R
LPL
A
RFH
Y
RI
FGII
S
F
SL
LL
T
G
FLS
YS
GN
V
V
L
A
K
L
VSN
GW
S
NN
F
LN
A
AF
T
SAL
M
F
G
Y
F
I
GSL
TG
G
F
I
G
D
YF
GRR
R
A
F
R
I
N
L
L
I
V
G
I
A
A
TGAA
FV
PD
M
YW
LI
FF
R
F
L
M
G
T
G
M
GA
LI
M
VG
Y
A
SF
TEF
I
P
A
T
V
RG
-------
--------
-K
W
S
AR
---
L
S
F
VG
-
--------N
W
SP
ML
-
SAAI
G
V
VV
I
AFF
S
W
RI
MFLLGGIGILLAWFLSGKYFI
ESPRWL
AG
KG
Q
I
A
G
AE
SQ
L
R
E
V
--
--
-
----
EQ
QIE
R
E
K
S
V
R
LPPLT
LN
QSNSK
AN
VI
N
GTFW
L
LF
KG
E
ML
RRTL
V
AITVLI
A
M
--
N
I
S
L
Y
T
I
TV
W
I
PTI
FVNS
G
I
D
V
D
K
-
-
---
S
ILMT
A
VI
M
I
GA
PVGIF
I
AA
L
I
ID
H
FPR
R
-
--
L
F
GS
A
LL
I
I--
I
AVLG
Y
I
Y
S
I
Q
TT
EWAILIYG
LV
MI
F
F
L
Y
M
Y
VC
F
A
SA
--
--
--
V
Y
I
P
EL
W
PT
HL
R
LR
G
S
GF
VN
A
V
G
RI
V
A
V
FTP
YG
VA
A
------
L
L
T
H
YG
S
I
T
V
F
I
V
LG
V
M
L
V
L
C
A
LV
L
S
-I
F
GI
ETR
K
V
SL
EEI
S
E
V
fig|358709.5.peg.3272
Escherichia coli 101-1 (29-474/475)
Q
IGARL
D
R
LPL
A
RFH
Y
RI
FGII
S
F
SL
LL
T
G
FLS
YS
GN
V
V
L
A
K
L
VSN
GW
S
NN
F
LN
A
AF
T
SAL
M
F
G
Y
F
I
GSL
TG
G
F
I
G
D
YF
GRR
R
A
F
R
I
N
L
L
I
V
G
I
A
A
TGAA
FV
PD
M
YW
LI
FF
R
F
L
M
G
T
G
M
GA
LI
M
VG
Y
A
SF
TEF
I
P
A
T
V
RG
-------
--------
-K
W
S
AR
---
L
S
F
VG
-
--------N
W
SP
ML
-
SAAI
G
V
VV
I
AFF
S
W
RI
MFLLGGIGILLAW
L
LSGKYFI
ESPRWL
AG
KG
Q
I
A
G
AE
CQ
L
R
E
V
--
--
-
----
EQ
QIE
R
E
K
S
IR
LPPLT
SY
QSNSKVKVIKGTFW
L
LF
KG
E
ML
RRTL
V
AITVLI
A
M
--
N
I
S
L
Y
T
I
TV
W
I
PTI
FVNS
G
I
D
V
D
K
-
-
---
S
ILMT
A
VI
M
I
GA
PVGIF
I
AA
L
I
ID
H
FPR
R
-
--
L
F
GS
T
LL
I
I--
I
AVLG
Y
I
Y
S
I
Q
TT
EWAILIYG
LV
MI
F
F
L
Y
M
Y
VC
F
A
SA
--
--
--
V
Y
I
P
EL
W
PT
HL
R
LR
G
S
GF
VN
A
V
G
RI
V
A
V
FTP
YG
VA
A
------
L
L
T
H
YG
S
I
T
V
F
M
V
LG
V
M
L
L
L
C
A
LV
L
S
-I
F
GI
ETR
K
V
SL
EEI
S
E
V
fig|413997.3.peg.1819
Escherichia coli B str. REL606 (29-474/475)
Q
IGARL
D
R
LPL
A
RFH
Y
RI
FGII
S
F
SL
LL
T
G
FLS
YS
GN
V
V
L
A
K
L
VSN
GW
S
NN
F
LN
A
AF
T
SAL
M
F
G
Y
F
I
GSL
TG
G
F
I
G
D
YF
GRR
R
A
F
R
I
N
L
L
I
V
G
I
A
A
TGAA
FV
PD
M
YW
LI
FF
R
F
L
M
G
T
G
M
GA
LI
M
VG
Y
A
SF
TEF
I
P
A
T
V
RG
-------
--------
-K
W
S
AR
---
L
S
F
VG
-
--------N
W
SP
ML
-
SAAI
G
V
VV
I
AFF
S
W
RI
MFLLGGIGILLAW
L
LSGKYFI
ESPRWL
AG
KG
Q
I
A
G
AE
CQ
L
R
E
V
--
--
-
----
EQ
QIE
R
E
K
S
IR
LPPLT
SY
QSNSKVKVIKGTFW
L
LF
KG
E
ML
RRTL
V
AITVLI
A
M
--
N
I
S
L
Y
T
I
TV
W
I
PTI
FVNS
G
I
D
V
D
K
-
-
---
S
ILMT
A
VI
M
I
GA
PVGIF
I
AA
L
I
ID
H
FPR
R
-
--
L
F
GS
T
LL
I
I--
I
AVLG
Y
I
Y
S
I
Q
TT
EWAILIYG
LV
MI
F
F
L
Y
M
Y
VC
F
A
SA
--
--
--
V
Y
I
P
EL
W
PT
HL
R
LR
G
S
GF
VN
A
V
G
RI
V
A
V
FTP
YG
VA
A
------
L
L
T
H
YG
S
I
T
V
F
M
V
LG
V
M
L
L
L
C
A
LV
L
S
-I
F
GI
ETR
K
V
SL
EEI
S
E
V
fig|511693.5.peg.1847
Escherichia coli BL21 (29-474/475)
Q
IGARL
D
R
LPL
A
RFH
Y
RI
FGII
S
F
SL
LL
T
G
FLS
YS
GN
V
V
L
A
K
L
VSN
GW
S
NN
F
LN
A
AF
T
SAL
M
F
G
Y
F
I
GSL
TG
G
F
I
G
D
YF
GRR
R
A
F
R
I
N
L
L
I
V
G
I
A
A
TGAA
FV
PD
M
YW
LI
FF
R
F
L
M
G
T
G
M
GA
LI
M
VG
Y
A
SF
TEF
I
P
A
T
V
RG
-------
--------
-K
W
S
AR
---
L
S
F
VG
-
--------N
W
SP
ML
-
SAAI
G
V
VV
I
AFF
S
W
RI
MFLLGGIGILLAW
L
LSGKYFI
ESPRWL
AG
KG
Q
I
A
G
AE
CQ
L
R
E
V
--
--
-
----
EQ
QIE
R
E
K
S
IR
LPPLT
SY
QSNSKVKVIKGTFW
L
LF
KG
E
ML
RRTL
V
AITVLI
A
M
--
N
I
S
L
Y
T
I
TV
W
I
PTI
FVNS
G
I
D
V
D
K
-
-
---
S
ILMT
A
VI
M
I
GA
PVGIF
I
AA
L
I
ID
H
FPR
R
-
--
L
F
GS
T
LL
I
I--
I
AVLG
Y
I
Y
S
I
Q
TT
EWAILIYG
LV
MI
F
F
L
Y
M
Y
VC
F
A
SA
--
--
--
V
Y
I
P
EL
W
PT
HL
R
LR
G
S
GF
VN
A
V
G
RI
V
A
V
FTP
YG
VA
A
------
L
L
T
H
YG
S
I
T
V
F
M
V
LG
V
M
L
L
L
C
A
LV
L
S
-I
F
GI
ETR
K
V
SL
EEI
S
E
V
fig|469008.4.peg.1931
Escherichia coli BL21(DE3) (29-474/475)
Q
IGARL
D
R
LPL
A
RFH
Y
RI
FGII
S
F
SL
LL
T
G
FLS
YS
GN
V
V
L
A
K
L
VSN
GW
S
NN
F
LN
A
AF
T
SAL
M
F
G
Y
F
I
GSL
TG
G
F
I
G
D
YF
GRR
R
A
F
R
I
N
L
L
I
V
G
I
A
A
TGAA
FV
PD
M
YW
LI
FF
R
F
L
M
G
T
G
M
GA
LI
M
VG
Y
A
SF
TEF
I
P
A
T
V
RG
-------
--------
-K
W
S
AR
---
L
S
F
VG
-
--------N
W
SP
ML
-
SAAI
G
V
VV
I
AFF
S
W
RI
MFLLGGIGILLAW
L
LSGKYFI
ESPRWL
AG
KG
Q
I
A
G
AE
CQ
L
R
E
V
--
--
-
----
EQ
QIE
R
E
K
S
IR
LPPLT
SY
QSNSKVKVIKGTFW
L
LF
KG
E
ML
RRTL
V
AITVLI
A
M
--
N
I
S
L
Y
T
I
TV
W
I
PTI
FVNS
G
I
D
V
D
K
-
-
---
S
ILMT
A
VI
M
I
GA
PVGIF
I
AA
L
I
ID
H
FPR
R
-
--
L
F
GS
T
LL
I
I--
I
AVLG
Y
I
Y
S
I
Q
TT
EWAILIYG
LV
MI
F
F
L
Y
M
Y
VC
F
A
SA
--
--
--
V
Y
I
P
EL
W
PT
HL
R
LR
G
S
GF
VN
A
V
G
RI
V
A
V
FTP
YG
VA
A
------
L
L
T
H
YG
S
I
T
V
F
M
V
LG
V
M
L
L
L
C
A
LV
L
S
-I
F
GI
ETR
K
V
SL
EEI
S
E
V
fig|340186.5.peg.2158
Escherichia coli E110019 (29-474/475)
Q
IGARL
D
R
LPL
A
RFH
Y
RI
FGII
S
F
SL
LL
T
G
FLS
YS
GN
V
V
L
A
K
L
VSN
GW
S
NN
F
LN
A
AF
T
SAL
M
F
G
Y
F
I
GSL
TG
G
F
I
G
D
YF
GRR
R
A
F
R
I
N
L
L
I
V
G
I
A
A
TGAA
FV
PD
M
YW
LI
FF
R
F
L
M
G
T
G
M
GA
LI
M
VG
Y
A
SF
TEF
I
P
A
T
V
RG
-------
--------
-K
W
S
AR
---
L
S
F
VG
-
--------N
W
SP
ML
-
SAAI
G
V
VV
I
AFF
S
W
RI
MFLLGGIGILLAW
L
LSGKYFI
ESPRWL
AG
KG
Q
I
A
G
AE
CQ
L
R
E
V
--
--
-
----
EQ
QIE
R
E
K
S
IR
LPPLT
SY
QSNSKVKVIKGTFW
L
LF
KG
E
ML
RRTL
V
AITVLI
A
M
--
N
I
S
L
Y
T
I
TV
W
I
PTI
FVNS
G
I
D
V
D
K
-
-
---
S
ILMT
A
VI
M
I
GA
PVGIF
I
AA
L
I
ID
H
FPR
R
-
--
L
F
GS
T
LL
I
I--
I
AVLG
Y
I
Y
S
I
Q
TT
EWAILIYG
LV
MI
F
F
L
Y
M
Y
VC
F
A
SA
--
--
--
V
Y
I
P
EL
W
PT
HL
R
LR
G
S
GF
VN
A
V
G
RI
V
A
V
FTP
YG
VA
A
------
L
L
T
H
YG
S
I
T
V
F
M
V
LG
V
M
L
L
L
C
A
LV
L
S
-I
F
GI
ETR
K
V
SL
EEI
S
E
V
fig|670888.3.peg.274
Escherichia coli 1827-70 (29-474/475)
Q
IGARL
D
R
LPL
A
RFH
Y
RI
FGII
S
F
SL
LL
T
G
FLS
YS
GN
V
V
L
A
K
L
VSN
GW
S
NN
F
LN
A
AF
T
SAL
M
F
G
Y
F
I
GSL
TG
G
F
I
G
D
YF
GRR
R
A
F
R
I
N
L
L
I
V
G
I
A
A
TGAA
FV
PD
M
YW
LI
FF
R
F
L
M
G
T
G
M
GA
LI
M
VG
Y
A
SF
TEF
I
P
A
T
V
RG
-------
--------
-K
W
S
AR
---
L
S
F
VG
-
--------N
W
SP
ML
-
SAAI
G
V
VV
I
AFF
S
W
RI
MFLLGGIGILLAW
L
LSGKYFI
ESPRWL
AG
KG
Q
I
A
G
AE
SQ
L
R
E
V
--
--
-
----
EQ
QIE
R
E
K
S
IR
LP
Q
LT
LN
QSNSKVKVIKGTFW
L
LF
KG
E
ML
RRTL
V
AITVLI
A
M
--
N
I
S
L
Y
T
I
TV
W
I
PTI
FVNS
G
I
D
V
D
K
-
-
---
S
ILMT
A
VI
M
I
GA
PVGIF
I
AA
L
I
ID
H
FPR
R
-
--
L
F
GS
A
LL
I
I--
I
AVLG
Y
I
Y
S
I
Q
TT
EWAILIYG
LV
MI
F
F
L
Y
M
Y
VC
F
A
SA
--
--
--
V
Y
I
P
EL
W
PT
HL
R
LR
G
S
GF
VN
A
V
G
RI
V
A
V
FTP
YG
VA
A
------
L
L
T
H
YG
S
I
T
V
F
M
V
LG
V
M
L
L
L
C
A
LV
L
S
-I
F
GI
ETR
K
V
SL
EEI
S
E
V
fig|481805.6.peg.2004
Escherichia coli ATCC 8739 (29-474/475)
Q
IGARL
D
R
LPL
A
RFH
Y
RI
FGII
S
F
SL
LL
T
G
FLS
YS
GN
V
V
L
A
K
L
VSN
GW
S
NN
F
LN
A
AF
T
SAL
M
F
G
Y
F
I
GSL
TG
G
F
I
G
D
YF
GRR
R
A
F
R
I
N
L
L
I
V
G
I
A
A
TGAA
FV
PD
M
YW
LI
FF
R
F
L
M
G
T
G
M
GA
LI
M
VG
Y
A
SF
TEF
I
P
A
T
V
RG
-------
--------
-K
W
S
AR
---
L
S
F
VG
-
--------N
W
SP
ML
-
SAAI
G
V
VV
I
AFF
S
W
RI
MFLLGGIGILLAW
L
LSGKYFI
ESPRWL
AG
KG
Q
I
A
G
AE
SQ
L
R
E
V
--
--
-
----
EQ
QIE
R
E
K
S
IR
LP
Q
LT
LN
QSNSKVKVIKGTFW
L
LF
KG
E
ML
RRTL
V
AITVLI
A
M
--
N
I
S
L
Y
T
I
TV
W
I
PTI
FVNS
G
I
D
V
D
K
-
-
---
S
ILMT
A
VI
M
I
GA
PVGIF
I
AA
L
I
ID
H
FPR
R
-
--
L
F
GS
A
LL
I
I--
I
AVLG
Y
I
Y
S
I
Q
TT
EWAILIYG
LV
MI
F
F
L
Y
M
Y
VC
F
A
SA
--
--
--
V
Y
I
P
EL
W
PT
HL
R
LR
G
S
GF
VN
A
V
G
RI
V
A
V
FTP
YG
VA
A
------
L
L
T
H
YG
S
I
T
V
F
M
V
LG
V
M
L
L
L
C
A
LV
L
S
-I
F
GI
ETR
K
V
SL
EEI
S
E
V
fig|340186.3.peg.2095
Escherichia coli E110019 (6-451/452)
Q
IGARL
D
R
LPL
A
RFH
Y
RI
FGII
S
F
SL
LL
T
G
FLS
YS
GN
V
V
L
A
K
L
VSN
GW
S
NN
F
LN
A
AF
T
SAL
M
F
G
Y
F
I
GSL
TG
G
F
I
G
D
YF
GRR
R
A
F
R
I
N
L
L
I
V
G
I
A
A
TGAA
FV
PD
M
YW
LI
FF
R
F
L
M
G
T
G
M
GA
LI
M
VG
Y
A
SF
TEF
I
P
A
T
V
RG
-------
--------
-K
W
S
AR
---
L
S
F
VG
-
--------N
W
SP
ML
-
SAAI
G
V
VV
I
AFF
S
W
RI
MFLLGGIGILLAW
L
LSGKYFI
ESPRWL
AG
KG
Q
I
A
G
AE
CQ
L
R
E
V
--
--
-
----
EQ
QIE
R
E
K
S
IR
LPPLT
SY
QSNSKVKVIKGTFW
L
LF
KG
E
ML
RRTL
V
AITVLI
A
M
--
N
I
S
L
Y
T
I
TV
W
I
PTI
FVNS
G
I
D
V
D
K
-
-
---
S
ILMT
A
VI
M
I
GA
PVGIF
I
AA
L
I
ID
H
FPR
R
-
--
L
F
GS
T
LL
I
I--
I
AVLG
Y
I
Y
S
I
Q
TT
EWAILIYG
LV
MI
F
F
L
Y
M
Y
VC
F
A
SA
--
--
--
V
Y
I
P
EL
W
PT
HL
R
LR
G
S
GF
VN
A
V
G
RI
V
A
V
FTP
YG
VA
A
------
L
L
T
H
YG
S
I
T
V
F
M
V
LG
V
M
L
L
L
C
A
LV
L
S
-I
F
GI
ETR
K
V
SL
EEI
S
E
V
fig|656419.3.peg.2488
Escherichia coli M718 (6-451/452)
Q
IGARL
D
R
LPL
A
RFH
Y
RI
FGII
S
F
SL
LL
T
G
FLS
YS
GN
V
V
L
A
K
L
VSN
GW
S
NN
F
LN
A
AF
T
SAL
M
F
G
Y
F
I
GSL
TG
G
F
I
G
D
YF
GRR
R
A
F
R
I
N
L
L
I
V
G
I
A
A
TGAA
FV
PD
M
YW
LI
FF
R
F
L
M
G
T
G
M
GA
LI
M
VG
Y
A
SF
TEF
I
P
A
T
V
RG
-------
--------
-K
W
S
AR
---
L
S
F
VG
-
--------N
W
SP
ML
-
SAAI
G
V
VV
I
AFF
S
W
RI
MFLLGGIGILLAW
L
LSGKYFI
ESPRWL
AG
KG
Q
I
A
G
AE
CQ
L
R
E
V
--
--
-
----
EQ
QIE
R
E
K
S
IR
LPPLT
SY
QSNSKVKVIKGTFW
L
LF
KG
E
ML
RRTL
V
AITVLI
A
M
--
N
I
S
L
Y
T
I
TV
W
I
PTI
FVNS
G
I
D
V
D
K
-
-
---
S
ILMT
A
VI
M
I
GA
PVGIF
I
AA
L
I
ID
H
FPR
R
-
--
L
F
GS
T
LL
I
I--
I
AVLG
Y
I
Y
S
I
Q
TT
EWAILIYG
LV
MI
F
F
L
Y
M
Y
VC
F
A
SA
--
--
--
V
Y
I
P
EL
W
PT
HL
R
LR
G
S
GF
VN
A
V
G
RI
V
A
V
FTP
YG
VA
A
------
L
L
T
H
YG
S
I
T
V
F
M
V
LG
V
M
L
L
L
C
A
LV
L
S
-I
F
GI
ETR
K
V
SL
EEI
S
E
V
fig|749547.3.peg.2909
Escherichia coli MS 187-1 (6-451/452)
Q
IGARL
D
R
LPL
A
RFH
Y
RI
FGII
S
F
SL
LL
T
G
FLS
YS
GN
V
V
L
A
K
L
VSN
GW
S
NN
F
LN
A
AF
T
SAL
M
F
G
Y
F
I
GSL
TG
G
F
I
G
D
YF
GRR
R
A
F
R
I
N
L
L
I
V
G
I
A
A
TGAA
FV
PD
M
YW
LI
FF
R
F
L
M
G
T
G
M
GA
LI
M
VG
Y
A
SF
TEF
I
P
A
T
V
RG
-------
--------
-K
W
S
AR
---
L
S
F
VG
-
--------N
W
SP
ML
-
SAAI
G
V
VV
I
AFF
S
W
RI
MFLLGGIGILLAW
L
LSGKYFI
ESPRWL
AG
KG
Q
I
A
G
AE
CQ
L
R
E
V
--
--
-
----
EQ
QIE
R
E
K
S
IR
LPPLT
SY
QSNSKVKVIKGTFW
L
LF
KG
E
ML
RRTL
V
AITVLI
A
M
--
N
I
S
L
Y
T
I
TV
W
I
PTI
FVNS
G
I
D
V
D
K
-
-
---
S
ILMT
A
VI
M
I
GA
PVGIF
I
AA
L
I
ID
H
FPR
R
-
--
L
F
GS
T
LL
I
I--
I
AVLG
Y
I
Y
S
I
Q
TT
EWAILIYG
LV
MI
F
F
L
Y
M
Y
VC
F
A
SA
--
--
--
V
Y
I
P
EL
W
PT
HL
R
LR
G
S
GF
VN
A
V
G
RI
V
A
V
FTP
YG
VA
A
------
L
L
T
H
YG
S
I
T
V
F
M
V
LG
V
M
L
L
L
C
A
LV
L
S
-I
F
GI
ETR
K
V
SL
EEI
S
E
V
fig|656437.3.peg.1999
Escherichia coli TA143 (6-451/452)
Q
IGARL
D
R
LPL
A
RFH
Y
RI
FGII
S
F
SL
LL
T
G
FLS
YS
GN
V
V
L
A
K
L
VSN
GW
S
NN
F
LN
A
AF
T
SAL
M
F
G
Y
F
I
GSL
TG
G
F
I
G
D
YF
GRR
R
A
F
R
I
N
L
L
I
V
G
I
A
A
TGAA
FV
PD
M
YW
LI
FF
R
F
L
M
G
T
G
M
GA
LI
M
VG
Y
A
SF
TEF
I
P
A
T
V
RG
-------
--------
-K
W
S
AR
---
L
S
F
VG
-
--------N
W
SP
ML
-
SAAI
G
V
VV
I
AFF
S
W
RI
MFLLGGIGILLAWFLSGKYFI
ESPRWL
AG
KG
Q
I
A
G
AE
SQ
L
R
E
V
--
--
-
----
EQ
QIE
R
E
K
S
V
R
LPPLT
LN
QSNSK
ANI
I
N
GTFW
L
LF
KG
E
ML
RRTL
V
AITVLI
A
M
--
N
I
S
L
Y
T
I
TV
W
I
PTI
FVNS
G
I
D
V
D
K
-
-
---
S
ILMT
A
VI
M
I
GA
PVGIF
I
AA
L
I
ID
H
FPR
R
-
--
L
F
GS
A
LL
I
I--
I
AVLG
Y
I
Y
S
I
Q
TT
EWAILIYG
LV
MI
F
F
L
Y
M
Y
VC
F
A
SA
--
--
--
V
Y
I
P
EL
W
PT
HL
R
LR
G
S
GF
VN
A
V
G
RI
V
A
V
FTP
YG
VA
A
------
L
L
T
H
YG
S
I
T
V
F
I
V
LG
V
M
L
V
L
C
A
LV
L
S
-I
F
GI
ETR
K
V
SL
EEI
S
E
V
fig|656444.3.peg.2685
Escherichia coli TA280 (6-451/452)
Q
IGARL
D
R
LPL
A
RFH
Y
RI
FGII
S
F
SL
LL
T
G
FLS
YS
GN
V
V
L
A
K
L
VSN
GW
S
NN
F
LN
A
AF
T
SAL
M
F
G
Y
F
I
GSL
TG
G
F
I
G
D
YF
GRR
R
A
F
R
I
N
L
L
I
V
G
I
A
A
TGAA
FV
PD
M
YW
LI
FF
R
F
L
M
G
T
G
M
GA
LI
M
VG
Y
A
SF
TEF
I
P
A
T
V
RG
-------
--------
-K
W
S
AR
---
L
S
F
VG
-
--------N
W
SP
ML
-
SAAI
G
V
VV
I
AFF
S
W
RI
MFLLGGIGILLAWFLSGKYFI
ESPRWL
AG
KG
Q
I
A
G
AE
SQ
L
R
E
V
--
--
-
----
EQ
QIE
R
E
K
S
V
R
LPPLT
LN
H
SNSK
AN
VI
N
GTFW
L
LF
KG
E
ML
RRTL
V
AITVLI
A
M
--
N
I
S
L
Y
T
I
TV
W
I
PTI
FVNS
G
I
D
V
D
K
-
-
---
S
ILMT
A
VI
M
I
GA
PVGIF
I
AA
L
I
ID
H
FPR
R
-
--
L
F
GS
T
LL
I
I--
I
AVLG
Y
I
Y
S
I
Q
TT
EWAILIYG
LV
MI
F
F
L
Y
M
Y
VC
F
A
SA
--
--
--
V
Y
I
P
EL
W
PT
HL
R
LR
G
S
GF
VN
A
V
G
RI
V
A
V
FTP
YG
VA
A
------
L
L
T
H
YG
S
I
T
V
F
I
V
LG
V
M
L
V
L
C
A
LV
L
S
-I
F
GI
ETR
K
V
SL
EEI
S
E
V
fig|749537.3.peg.1418
Escherichia coli MS 115-1 (6-451/452)
Q
IGARL
D
R
LPL
A
RFH
Y
RI
FGII
S
F
SL
LL
T
G
FLS
YS
GN
V
V
L
A
K
L
VSN
GW
S
NN
F
LN
A
AF
T
SAL
M
F
G
Y
F
I
GSL
TG
G
F
I
G
D
YF
GRR
R
A
F
R
I
N
L
L
I
V
G
I
A
A
TGAA
FV
PD
M
YW
LI
FF
R
F
L
M
G
T
G
M
GA
LI
M
VG
Y
A
SF
TEF
I
P
A
T
V
RG
-------
--------
-K
W
S
AR
---
L
S
F
VG
-
--------N
W
SP
ML
-
SAAI
G
V
VV
I
AFF
S
W
RI
MFLLGGIGILLAWFLSGKYFI
ESPRWL
AG
KG
Q
I
A
G
AE
SQ
L
H
E
V
--
--
-
----
EQ
QIE
R
E
K
S
IR
LPPLT
SY
QSNSKVKVIKGTFW
L
LF
KG
E
ML
RRTL
V
AITVLI
A
M
--
N
I
S
L
Y
T
I
TV
W
I
PTI
FVNS
G
I
D
V
D
K
-
-
---
S
ILMT
A
VI
M
I
GA
PVGIF
I
AA
L
I
ID
H
FPR
R
-
--
L
F
GS
T
LL
I
I--
I
AVLG
Y
I
Y
S
I
Q
TT
EWAILIYG
LV
MI
F
F
L
Y
M
Y
VC
F
A
SA
--
--
--
V
Y
I
P
EL
W
PT
HL
R
MR
G
S
GF
VN
A
V
G
RI
V
A
V
FTP
YG
VA
A
------
L
L
T
H
YG
S
I
T
V
F
M
V
LG
V
M
L
V
L
C
A
LV
L
S
-I
F
GI
ETR
K
V
SL
EEI
S
E
V
fig|481805.3.peg.2009
Escherichia coli ATCC 8739 (6-451/452)
Q
IGARL
D
R
LPL
A
RFH
Y
RI
FGII
S
F
SL
LL
T
G
FLS
YS
GN
V
V
L
A
K
L
VSN
GW
S
NN
F
LN
A
AF
T
SAL
M
F
G
Y
F
I
GSL
TG
G
F
I
G
D
YF
GRR
R
A
F
R
I
N
L
L
I
V
G
I
A
A
TGAA
FV
PD
M
YW
LI
FF
R
F
L
M
G
T
G
M
GA
LI
M
VG
Y
A
SF
TEF
I
P
A
T
V
RG
-------
--------
-K
W
S
AR
---
L
S
F
VG
-
--------N
W
SP
ML
-
SAAI
G
V
VV
I
AFF
S
W
RI
MFLLGGIGILLAW
L
LSGKYFI
ESPRWL
AG
KG
Q
I
A
G
AE
SQ
L
R
E
V
--
--
-
----
EQ
QIE
R
E
K
S
IR
LP
Q
LT
LN
QSNSKVKVIKGTFW
L
LF
KG
E
ML
RRTL
V
AITVLI
A
M
--
N
I
S
L
Y
T
I
TV
W
I
PTI
FVNS
G
I
D
V
D
K
-
-
---
S
ILMT
A
VI
M
I
GA
PVGIF
I
AA
L
I
ID
H
FPR
R
-
--
L
F
GS
A
LL
I
I--
I
AVLG
Y
I
Y
S
I
Q
TT
EWAILIYG
LV
MI
F
F
L
Y
M
Y
VC
F
A
SA
--
--
--
V
Y
I
P
EL
W
PT
HL
R
LR
G
S
GF
VN
A
V
G
RI
V
A
V
FTP
YG
VA
A
------
L
L
T
H
YG
S
I
T
V
F
M
V
LG
V
M
L
L
L
C
A
LV
L
S
-I
F
GI
ETR
K
V
SL
EEI
S
E
V
fig|1040638.4.peg.3837
Escherichia coli O104:H4 str. LB226692 (6-451/452)
Q
IGARL
D
R
LPL
A
RFH
Y
RI
FGII
S
F
SL
LL
T
G
FLS
YS
GN
V
V
L
A
K
L
VSN
GW
S
NN
F
LN
A
AF
T
SAL
M
F
G
Y
F
I
GSL
TG
G
F
I
G
D
YF
GRR
R
A
F
R
I
N
L
L
I
V
G
I
A
A
TGAA
FV
PD
M
YW
LI
FF
R
F
L
M
G
T
G
M
GA
LI
M
VG
Y
A
SF
TEF
I
P
A
T
V
RG
-------
--------
-K
W
S
AR
---
L
S
F
VG
-
--------N
W
SP
ML
-
SAAI
G
V
VV
I
AFF
S
W
RI
MFLLGGIGILLAWFLSGKYFI
ESPRWL
AG
KG
Q
I
A
G
AE
SQ
L
R
E
V
--
--
-
----
EQ
QIE
R
E
K
S
IR
LP
Q
LT
LN
QSNSKVKVIKGTFW
L
LF
KG
E
ML
RRTL
V
AITVLI
A
M
--
N
I
S
L
Y
T
I
TV
W
I
PTI
FVNS
G
I
D
V
D
K
-
-
---
S
ILMT
A
VI
M
I
GA
PVGIF
I
AA
L
I
ID
H
FPR
R
-
--
L
F
GS
A
LL
I
I--
I
AVLG
Y
I
Y
S
I
Q
TT
EWAILIYG
LV
MI
F
F
L
Y
M
Y
VC
F
A
SA
--
--
--
V
Y
I
P
EL
W
PT
HL
R
LR
G
S
GF
VN
A
V
G
RI
V
A
V
FTP
YG
VA
A
------
L
L
T
H
YG
S
I
T
V
F
M
V
LG
V
M
L
V
L
C
A
LV
L
S
-I
F
GI
ETR
K
V
SL
EEI
S
E
V
fig|6666666.5357.peg.297
Escherichia coli TY-2482 (6-451/452)
Q
IGARL
D
R
LPL
A
RFH
Y
RI
FGII
S
F
SL
LL
T
G
FLS
YS
GN
V
V
L
A
K
L
VSN
GW
S
NN
F
LN
A
AF
T
SAL
M
F
G
Y
F
I
GSL
TG
G
F
I
G
D
YF
GRR
R
A
F
R
I
N
L
L
I
V
G
I
A
A
TGAA
FV
PD
M
YW
LI
FF
R
F
L
M
G
T
G
M
GA
LI
M
VG
Y
A
SF
TEF
I
P
A
T
V
RG
-------
--------
-K
W
S
AR
---
L
S
F
VG
-
--------N
W
SP
ML
-
SAAI
G
V
VV
I
AFF
S
W
RI
MFLLGGIGILLAWFLSGKYFI
ESPRWL
AG
KG
Q
I
A
G
AE
SQ
L
R
E
V
--
--
-
----
EQ
QIE
R
E
K
S
IR
LP
Q
LT
LN
QSNSKVKVIKGTFW
L
LF
KG
E
ML
RRTL
V
AITVLI
A
M
--
N
I
S
L
Y
T
I
TV
W
I
PTI
FVNS
G
I
D
V
D
K
-
-
---
S
ILMT
A
VI
M
I
GA
PVGIF
I
AA
L
I
ID
H
FPR
R
-
--
L
F
GS
A
LL
I
I--
I
AVLG
Y
I
Y
S
I
Q
TT
EWAILIYG
LV
MI
F
F
L
Y
M
Y
VC
F
A
SA
--
--
--
V
Y
I
P
EL
W
PT
HL
R
LR
G
S
GF
VN
A
V
G
RI
V
A
V
FTP
YG
VA
A
------
L
L
T
H
YG
S
I
T
V
F
M
V
LG
V
M
L
V
L
C
A
LV
L
S
-I
F
GI
ETR
K
V
SL
EEI
S
E
V
fig|585055.6.peg.1968
Escherichia coli 55989 (6-451/452)
Q
IGARL
D
R
LPL
A
RFH
Y
RI
FGII
S
F
SL
LL
T
G
FLS
YS
GN
V
V
L
A
K
L
VSN
GW
S
NN
F
LN
A
AF
T
SAL
M
F
G
Y
F
I
GSL
TG
G
F
I
G
D
YF
GRR
R
A
F
R
I
N
L
L
I
V
G
I
A
A
TGAA
FV
PD
M
YW
LI
FF
R
F
L
M
G
T
G
M
GA
LI
M
VG
Y
A
SF
TEF
I
P
A
T
V
RG
-------
--------
-K
W
S
AR
---
L
S
F
VG
-
--------N
W
SP
ML
-
SAAI
G
V
VV
I
AFF
S
W
RI
MFLLGGIGILLAWFLSGKYFI
ESPRWL
AG
KG
Q
I
A
G
AE
SQ
L
R
E
V
--
--
-
----
EQ
QIE
R
E
K
S
IR
LP
Q
LT
LN
QSNSKVKVIKGTFW
L
LF
KG
E
ML
RRTL
V
AITVLI
A
M
--
N
I
S
L
Y
T
I
TV
W
I
PTI
FVNS
G
I
D
V
D
K
-
-
---
S
ILMT
A
VI
M
I
GA
PVGIF
I
AA
L
I
ID
H
FPR
R
-
--
L
F
GS
A
LL
I
I--
I
AVLG
Y
I
Y
S
I
Q
TT
EWAILIYG
LV
MI
F
F
L
Y
M
Y
VC
F
A
SA
--
--
--
V
Y
I
P
EL
W
PT
HL
R
LR
G
S
GF
VN
A
V
G
RI
V
A
V
FTP
YG
VA
A
------
L
L
T
H
YG
S
I
T
V
F
M
V
LG
V
M
L
V
L
C
A
LV
L
S
-I
F
GI
ETR
K
V
SL
EEI
S
E
V
fig|585055.8.peg.1971
Escherichia coli 55989 (6-451/452)
Q
IGARL
D
R
LPL
A
RFH
Y
RI
FGII
S
F
SL
LL
T
G
FLS
YS
GN
V
V
L
A
K
L
VSN
GW
S
NN
F
LN
A
AF
T
SAL
M
F
G
Y
F
I
GSL
TG
G
F
I
G
D
YF
GRR
R
A
F
R
I
N
L
L
I
V
G
I
A
A
TGAA
FV
PD
M
YW
LI
FF
R
F
L
M
G
T
G
M
GA
LI
M
VG
Y
A
SF
TEF
I
P
A
T
V
RG
-------
--------
-K
W
S
AR
---
L
S
F
VG
-
--------N
W
SP
ML
-
SAAI
G
V
VV
I
AFF
S
W
RI
MFLLGGIGILLAWFLSGKYFI
ESPRWL
AG
KG
Q
I
A
G
AE
SQ
L
R
E
V
--
--
-
----
EQ
QIE
R
E
K
S
IR
LP
Q
LT
LN
QSNSKVKVIKGTFW
L
LF
KG
E
ML
RRTL
V
AITVLI
A
M
--
N
I
S
L
Y
T
I
TV
W
I
PTI
FVNS
G
I
D
V
D
K
-
-
---
S
ILMT
A
VI
M
I
GA
PVGIF
I
AA
L
I
ID
H
FPR
R
-
--
L
F
GS
A
LL
I
I--
I
AVLG
Y
I
Y
S
I
Q
TT
EWAILIYG
LV
MI
F
F
L
Y
M
Y
VC
F
A
SA
--
--
--
V
Y
I
P
EL
W
PT
HL
R
LR
G
S
GF
VN
A
V
G
RI
V
A
V
FTP
YG
VA
A
------
L
L
T
H
YG
S
I
T
V
F
M
V
LG
V
M
L
V
L
C
A
LV
L
S
-I
F
GI
ETR
K
V
SL
EEI
S
E
V
fig|679205.4.peg.2450
Escherichia coli MS 124-1 (6-451/452)
Q
IGARL
D
R
LPL
A
RFH
Y
RI
FGII
S
F
SL
LL
T
G
FLS
YS
GN
V
V
L
A
K
L
VSN
GW
S
NN
F
LN
A
AF
T
SAL
M
F
G
Y
F
I
GSL
TG
G
F
I
G
D
YF
GRR
R
A
F
R
I
N
L
L
I
V
G
I
A
A
TGAA
FV
PD
M
YW
LI
FF
R
F
L
M
G
T
G
M
GA
LI
M
VG
Y
A
SF
TEF
I
P
A
T
V
RG
-------
--------
-K
W
S
AR
---
L
S
F
VG
-
--------N
W
SP
ML
-
SAAI
G
V
VV
I
AFF
S
W
RI
MFLLGGIGILLAWFLSGKYFI
ESPRWL
AG
KG
Q
I
A
G
AE
SQ
L
R
E
V
--
--
-
----
EQ
QIE
R
E
K
S
IR
LP
Q
LT
LN
QSNSKVKVIKGTFW
L
LF
KG
E
ML
RRTL
V
AITVLI
A
M
--
N
I
S
L
Y
T
I
TV
W
I
PTI
FVNS
G
I
D
V
D
K
-
-
---
S
ILMT
A
VI
M
I
GA
PVGIF
I
AA
L
I
ID
H
FPR
R
-
--
L
F
GS
A
LL
I
I--
I
AVLG
Y
I
Y
S
I
Q
TT
EWAILIYG
LV
MI
F
F
L
Y
M
Y
VC
F
A
SA
--
--
--
V
Y
I
P
EL
W
PT
HL
R
LR
G
S
GF
VN
A
V
G
RI
V
A
V
FTP
YG
VA
A
------
L
L
T
H
YG
S
I
T
V
F
M
V
LG
V
M
L
V
L
C
A
LV
L
S
-I
F
GI
ETR
K
V
SL
EEI
S
E
V
fig|749533.3.peg.2732
Escherichia coli MS 84-1 (6-451/452)
Q
IGARL
D
R
LPL
A
RFH
Y
RI
FGII
S
F
SL
LL
T
G
FLS
YS
GN
V
V
L
A
K
L
VSN
GW
S
NN
F
LN
A
AF
T
SAL
M
F
G
Y
F
I
GSL
TG
G
F
I
G
D
YF
GRR
R
A
F
R
I
N
L
L
I
V
G
I
A
A
TGAA
FV
PD
M
YW
LI
FF
R
F
L
M
G
T
G
M
GA
LI
M
VG
Y
A
SF
TEF
I
P
A
T
V
RG
-------
--------
-K
W
S
AR
---
L
S
F
VG
-
--------N
W
SP
ML
-
SAAI
G
V
VV
I
AFF
S
W
RI
MFLLGGIGILLAWFLSGKYFI
ESPRWL
AG
KG
Q
I
A
G
AE
SQ
L
R
E
V
--
--
-
----
EQ
QIE
R
E
K
S
IR
LP
Q
LT
LN
QSNSKVKVIKGTFW
L
LF
KG
E
ML
RRTL
V
AITVLI
A
M
--
N
I
S
L
Y
T
I
TV
W
I
PTI
FVNS
G
I
D
V
D
K
-
-
---
S
ILMT
A
VI
M
I
GA
PVGIF
I
AA
L
I
ID
H
FPR
R
-
--
L
F
GS
A
LL
I
I--
I
AVLG
Y
I
Y
S
I
Q
TT
EWAILIYG
LV
MI
F
F
L
Y
M
Y
VC
F
A
SA
--
--
--
V
Y
I
P
EL
W
PT
HL
R
LR
G
S
GF
VN
A
V
G
RI
V
A
V
FTP
YG
VA
A
------
L
L
T
H
YG
S
I
T
V
F
M
V
LG
V
M
L
V
L
C
A
LV
L
S
-I
F
GI
ETR
K
V
SL
EEI
S
E
V
fig|409438.11.peg.2088
Escherichia coli SE11 (6-451/452)
Q
IGARL
D
R
LPL
A
RFH
Y
RI
FGII
S
F
SL
LL
T
G
FLS
YS
GN
V
V
L
A
K
L
VSN
GW
S
NN
F
LN
A
AF
T
SAL
M
F
G
Y
F
I
GSL
TG
G
F
I
G
D
YF
GRR
R
A
F
R
I
N
L
L
I
V
G
I
A
A
TGAA
FV
PD
M
YW
LI
FF
R
F
L
M
G
T
G
M
GA
LI
M
VG
Y
A
SF
TEF
I
P
A
T
V
RG
-------
--------
-K
W
S
AR
---
L
S
F
VG
-
--------N
W
SP
ML
-
SAAI
G
V
VV
I
AFF
S
W
RI
MFLLGGIGILLAWFLSGKYFI
ESPRWL
AG
KG
Q
I
A
G
AE
SQ
L
R
E
V
--
--
-
----
EQ
QIE
R
E
K
S
IR
LP
Q
LT
LN
QSNSKVKVIKGTFW
L
LF
KG
E
ML
RRTL
V
AITVLI
A
M
--
N
I
S
L
Y
T
I
TV
W
I
PTI
FVNS
G
I
D
V
D
K
-
-
---
S
ILMT
A
VI
M
I
GA
PVGIF
I
AA
L
I
ID
H
FPR
R
-
--
L
F
GS
A
LL
I
I--
I
AVLG
Y
I
Y
S
I
Q
TT
EWAILIYG
LV
MI
F
F
L
Y
M
Y
VC
F
A
SA
--
--
--
V
Y
I
P
EL
W
PT
HL
R
LR
G
S
GF
VN
A
V
G
RI
V
A
V
FTP
YG
VA
A
------
L
L
T
H
YG
S
I
T
V
F
M
V
LG
V
M
L
V
L
C
A
LV
L
S
-I
F
GI
ETR
K
V
SL
EEI
S
E
V
fig|550676.3.peg.2082
Escherichia coli B185 (29-474/475)
Q
IGARL
D
R
LPL
A
RFH
Y
RI
FGII
S
F
SL
LL
T
G
FLS
YS
GN
V
V
L
A
K
L
VSN
GW
S
NN
F
LN
A
AF
T
SAL
M
F
G
Y
F
I
GSL
TG
G
F
I
G
D
YF
GRR
R
A
F
R
I
N
L
L
I
V
G
I
A
A
TGAT
FV
PD
M
YW
LI
FF
R
F
L
M
G
T
G
M
GA
LI
M
VG
Y
A
SF
TEF
I
P
A
T
V
RG
-------
--------
-K
W
S
AR
---
L
S
F
VG
-
--------N
W
SP
ML
-
SAAI
G
V
VV
I
AFF
S
W
RI
MFLLGGIGILLAWFLSGKYFI
ESPRWL
AG
KG
Q
I
A
G
AE
SQ
L
R
E
V
--
--
-
----
EQ
QIE
R
E
K
S
IR
LPPLT
SY
QSNSKVKVIKGTFW
L
LF
KG
E
ML
RRTL
V
AITVLI
A
M
--
N
I
S
L
Y
T
I
TV
W
I
PTI
FVNS
G
I
D
V
D
K
-
-
---
S
ILMT
A
VI
M
I
GA
PVGIF
I
AA
L
I
ID
H
FPR
R
-
--
L
F
GS
T
LL
I
I--
I
AVLG
Y
I
Y
S
I
Q
TT
EWAILIYG
LV
MI
F
F
L
Y
M
Y
VC
F
A
SA
--
--
--
V
Y
I
P
EL
W
PT
HL
R
LR
G
S
GF
VN
A
V
G
RI
V
A
V
FTP
YG
VA
A
------
L
L
T
H
YG
S
I
T
V
F
M
V
LG
V
M
L
L
L
C
A
LV
L
S
-I
F
GI
ETR
K
V
SL
EEI
S
E
V
fig|595496.3.peg.1733
Escherichia coli BW2952 (6-451/452)
Q
IGARL
D
R
LPL
A
RFH
Y
RI
FGII
S
F
SL
LL
T
G
FLS
YS
GN
V
V
L
A
K
L
VSN
GW
S
NN
F
LN
A
AF
T
SAL
M
F
G
Y
F
I
GSL
TG
G
F
I
G
D
YF
GRR
R
A
F
R
I
N
L
L
I
V
G
I
A
A
TGAA
FV
PD
M
YW
LI
FF
R
F
L
M
G
T
G
M
GA
LI
M
VG
Y
A
SF
TEF
I
P
A
T
V
RG
-------
--------
-K
W
S
AR
---
L
S
F
VG
-
--------N
W
SP
ML
-
SAAI
G
V
VV
I
AFF
S
W
RI
MFLLGGIGILLAWFLSGKYFI
ESPRWL
AG
KG
Q
I
A
G
AE
CQ
L
R
E
V
--
--
-
----
EQ
QIE
R
E
K
S
IR
LPPLT
SY
QSNSKVKVIKGTFW
L
LF
KG
E
ML
RRTL
V
AITVLI
A
M
--
N
I
S
L
Y
T
I
TV
W
I
PTI
FVNS
G
I
D
V
D
K
-
-
---
S
ILMT
A
VI
M
I
GA
PVGIF
I
AA
L
I
ID
H
FPR
R
-
--
L
F
GS
T
LL
I
I--
I
AVLG
Y
I
Y
S
I
Q
TT
EWAILIYG
LV
MI
F
F
L
Y
M
Y
VC
F
A
SA
--
--
--
V
Y
I
P
EL
W
PT
HL
R
LR
G
S
GF
VN
A
V
G
RI
V
A
V
FTP
YG
VA
A
------
L
L
T
H
YG
S
I
T
V
F
M
V
LG
V
M
L
L
L
C
A
LV
L
S
-I
F
GI
ETR
K
V
SL
EEI
S
E
V
fig|536056.3.peg.1981
Escherichia coli DH1 (6-451/452)
Q
IGARL
D
R
LPL
A
RFH
Y
RI
FGII
S
F
SL
LL
T
G
FLS
YS
GN
V
V
L
A
K
L
VSN
GW
S
NN
F
LN
A
AF
T
SAL
M
F
G
Y
F
I
GSL
TG
G
F
I
G
D
YF
GRR
R
A
F
R
I
N
L
L
I
V
G
I
A
A
TGAA
FV
PD
M
YW
LI
FF
R
F
L
M
G
T
G
M
GA
LI
M
VG
Y
A
SF
TEF
I
P
A
T
V
RG
-------
--------
-K
W
S
AR
---
L
S
F
VG
-
--------N
W
SP
ML
-
SAAI
G
V
VV
I
AFF
S
W
RI
MFLLGGIGILLAWFLSGKYFI
ESPRWL
AG
KG
Q
I
A
G
AE
CQ
L
R
E
V
--
--
-
----
EQ
QIE
R
E
K
S
IR
LPPLT
SY
QSNSKVKVIKGTFW
L
LF
KG
E
ML
RRTL
V
AITVLI
A
M
--
N
I
S
L
Y
T
I
TV
W
I
PTI
FVNS
G
I
D
V
D
K
-
-
---
S
ILMT
A
VI
M
I
GA
PVGIF
I
AA
L
I
ID
H
FPR
R
-
--
L
F
GS
T
LL
I
I--
I
AVLG
Y
I
Y
S
I
Q
TT
EWAILIYG
LV
MI
F
F
L
Y
M
Y
VC
F
A
SA
--
--
--
V
Y
I
P
EL
W
PT
HL
R
LR
G
S
GF
VN
A
V
G
RI
V
A
V
FTP
YG
VA
A
------
L
L
T
H
YG
S
I
T
V
F
M
V
LG
V
M
L
L
L
C
A
LV
L
S
-I
F
GI
ETR
K
V
SL
EEI
S
E
V
fig|83333.1.peg.1752
Escherichia coli K12 (6-451/452)
Q
IGARL
D
R
LPL
A
RFH
Y
RI
FGII
S
F
SL
LL
T
G
FLS
YS
GN
V
V
L
A
K
L
VSN
GW
S
NN
F
LN
A
AF
T
SAL
M
F
G
Y
F
I
GSL
TG
G
F
I
G
D
YF
GRR
R
A
F
R
I
N
L
L
I
V
G
I
A
A
TGAA
FV
PD
M
YW
LI
FF
R
F
L
M
G
T
G
M
GA
LI
M
VG
Y
A
SF
TEF
I
P
A
T
V
RG
-------
--------
-K
W
S
AR
---
L
S
F
VG
-
--------N
W
SP
ML
-
SAAI
G
V
VV
I
AFF
S
W
RI
MFLLGGIGILLAWFLSGKYFI
ESPRWL
AG
KG
Q
I
A
G
AE
CQ
L
R
E
V
--
--
-
----
EQ
QIE
R
E
K
S
IR
LPPLT
SY
QSNSKVKVIKGTFW
L
LF
KG
E
ML
RRTL
V
AITVLI
A
M
--
N
I
S
L
Y
T
I
TV
W
I
PTI
FVNS
G
I
D
V
D
K
-
-
---
S
ILMT
A
VI
M
I
GA
PVGIF
I
AA
L
I
ID
H
FPR
R
-
--
L
F
GS
T
LL
I
I--
I
AVLG
Y
I
Y
S
I
Q
TT
EWAILIYG
LV
MI
F
F
L
Y
M
Y
VC
F
A
SA
--
--
--
V
Y
I
P
EL
W
PT
HL
R
LR
G
S
GF
VN
A
V
G
RI
V
A
V
FTP
YG
VA
A
------
L
L
T
H
YG
S
I
T
V
F
M
V
LG
V
M
L
L
L
C
A
LV
L
S
-I
F
GI
ETR
K
V
SL
EEI
S
E
V
fig|749540.3.peg.4189
Escherichia coli MS 146-1 (6-451/452)
Q
IGARL
D
R
LPL
A
RFH
Y
RI
FGII
S
F
SL
LL
T
G
FLS
YS
GN
V
V
L
A
K
L
VSN
GW
S
NN
F
LN
A
AF
T
SAL
M
F
G
Y
F
I
GSL
TG
G
F
I
G
D
YF
GRR
R
A
F
R
I
N
L
L
I
V
G
I
A
A
TGAA
FV
PD
M
YW
LI
FF
R
F
L
M
G
T
G
M
GA
LI
M
VG
Y
A
SF
TEF
I
P
A
T
V
RG
-------
--------
-K
W
S
AR
---
L
S
F
VG
-
--------N
W
SP
ML
-
SAAI
G
V
VV
I
AFF
S
W
RI
MFLLGGIGILLAWFLSGKYFI
ESPRWL
AG
KG
Q
I
A
G
AE
CQ
L
R
E
V
--
--
-
----
EQ
QIE
R
E
K
S
IR
LPPLT
SY
QSNSKVKVIKGTFW
L
LF
KG
E
ML
RRTL
V
AITVLI
A
M
--
N
I
S
L
Y
T
I
TV
W
I
PTI
FVNS
G
I
D
V
D
K
-
-
---
S
ILMT
A
VI
M
I
GA
PVGIF
I
AA
L
I
ID
H
FPR
R
-
--
L
F
GS
T
LL
I
I--
I
AVLG
Y
I
Y
S
I
Q
TT
EWAILIYG
LV
MI
F
F
L
Y
M
Y
VC
F
A
SA
--
--
--
V
Y
I
P
EL
W
PT
HL
R
LR
G
S
GF
VN
A
V
G
RI
V
A
V
FTP
YG
VA
A
------
L
L
T
H
YG
S
I
T
V
F
M
V
LG
V
M
L
L
L
C
A
LV
L
S
-I
F
GI
ETR
K
V
SL
EEI
S
E
V
fig|749548.3.peg.970
Escherichia coli MS 196-1 (6-451/452)
Q
IGARL
D
R
LPL
A
RFH
Y
RI
FGII
S
F
SL
LL
T
G
FLS
YS
GN
V
V
L
A
K
L
VSN
GW
S
NN
F
LN
A
AF
T
SAL
M
F
G
Y
F
I
GSL
TG
G
F
I
G
D
YF
GRR
R
A
F
R
I
N
L
L
I
V
G
I
A
A
TGAA
FV
PD
M
YW
LI
FF
R
F
L
M
G
T
G
M
GA
LI
M
VG
Y
A
SF
TEF
I
P
A
T
V
RG
-------
--------
-K
W
S
AR
---
L
S
F
VG
-
--------N
W
SP
ML
-
SAAI
G
V
VV
I
AFF
S
W
RI
MFLLGGIGILLAWFLSGKYFI
ESPRWL
AG
KG
Q
I
A
G
AE
CQ
L
R
E
V
--
--
-
----
EQ
QIE
R
E
K
S
IR
LPPLT
SY
QSNSKVKVIKGTFW
L
LF
KG
E
ML
RRTL
V
AITVLI
A
M
--
N
I
S
L
Y
T
I
TV
W
I
PTI
FVNS
G
I
D
V
D
K
-
-
---
S
ILMT
A
VI
M
I
GA
PVGIF
I
AA
L
I
ID
H
FPR
R
-
--
L
F
GS
T
LL
I
I--
I
AVLG
Y
I
Y
S
I
Q
TT
EWAILIYG
LV
MI
F
F
L
Y
M
Y
VC
F
A
SA
--
--
--
V
Y
I
P
EL
W
PT
HL
R
LR
G
S
GF
VN
A
V
G
RI
V
A
V
FTP
YG
VA
A
------
L
L
T
H
YG
S
I
T
V
F
M
V
LG
V
M
L
L
L
C
A
LV
L
S
-I
F
GI
ETR
K
V
SL
EEI
S
E
V
fig|701177.3.peg.2219
Escherichia coli O55:H7 str. CB9615 (6-451/452)
Q
IGARL
D
R
LPL
A
RFH
Y
RI
FGII
S
F
SL
LL
T
G
FLS
YS
GN
V
V
L
A
K
L
VSN
GW
S
NN
F
LN
A
AF
T
SAL
M
F
G
Y
F
I
GSL
TG
G
F
I
G
D
YF
GRR
R
A
F
R
I
N
L
L
I
V
G
I
A
A
TGAA
FV
PD
M
YW
LI
FF
R
F
L
M
G
T
G
M
GA
LI
M
VG
Y
A
SF
TEF
I
P
A
T
V
RG
-------
--------
-K
W
S
AR
---
L
S
F
VG
-
--------N
W
SP
ML
-
SAAI
G
V
VV
I
AFF
S
W
RI
MFLLGGIGILLAWFLSGKYFI
ESPRWL
AG
KG
Q
I
A
G
AE
CQ
L
R
E
V
--
--
-
----
EQ
QIE
R
E
K
S
IR
LPPLT
SY
QSNSKVKVIKGTFW
L
LF
KG
E
ML
RRTL
V
AITVLI
A
M
--
N
I
S
L
Y
T
I
TV
W
I
PTI
FVNS
G
I
D
V
D
K
-
-
---
S
ILMT
A
VI
M
I
GA
PVGIF
I
AA
L
I
ID
H
FPR
R
-
--
L
F
GS
T
LL
I
I--
I
AVLG
Y
I
Y
S
I
Q
TT
EWAILIYG
LV
MI
F
F
L
Y
M
Y
VC
F
A
SA
--
--
--
V
Y
I
P
EL
W
PT
HL
R
LR
G
S
GF
VN
A
V
G
RI
V
A
V
FTP
YG
VA
A
------
L
L
T
H
YG
S
I
T
V
F
M
V
LG
V
M
L
L
L
C
A
LV
L
S
-I
F
GI
ETR
K
V
SL
EEI
S
E
V
fig|316407.3.peg.1724
Escherichia coli W3110 (6-451/452)
Q
IGARL
D
R
LPL
A
RFH
Y
RI
FGII
S
F
SL
LL
T
G
FLS
YS
GN
V
V
L
A
K
L
VSN
GW
S
NN
F
LN
A
AF
T
SAL
M
F
G
Y
F
I
GSL
TG
G
F
I
G
D
YF
GRR
R
A
F
R
I
N
L
L
I
V
G
I
A
A
TGAA
FV
PD
M
YW
LI
FF
R
F
L
M
G
T
G
M
GA
LI
M
VG
Y
A
SF
TEF
I
P
A
T
V
RG
-------
--------
-K
W
S
AR
---
L
S
F
VG
-
--------N
W
SP
ML
-
SAAI
G
V
VV
I
AFF
S
W
RI
MFLLGGIGILLAWFLSGKYFI
ESPRWL
AG
KG
Q
I
A
G
AE
CQ
L
R
E
V
--
--
-
----
EQ
QIE
R
E
K
S
IR
LPPLT
SY
QSNSKVKVIKGTFW
L
LF
KG
E
ML
RRTL
V
AITVLI
A
M
--
N
I
S
L
Y
T
I
TV
W
I
PTI
FVNS
G
I
D
V
D
K
-
-
---
S
ILMT
A
VI
M
I
GA
PVGIF
I
AA
L
I
ID
H
FPR
R
-
--
L
F
GS
T
LL
I
I--
I
AVLG
Y
I
Y
S
I
Q
TT
EWAILIYG
LV
MI
F
F
L
Y
M
Y
VC
F
A
SA
--
--
--
V
Y
I
P
EL
W
PT
HL
R
LR
G
S
GF
VN
A
V
G
RI
V
A
V
FTP
YG
VA
A
------
L
L
T
H
YG
S
I
T
V
F
M
V
LG
V
M
L
L
L
C
A
LV
L
S
-I
F
GI
ETR
K
V
SL
EEI
S
E
V
fig|316385.5.peg.1887
Escherichia coli str. K-12 substr. DH10B (6-451/452)
Q
IGARL
D
R
LPL
A
RFH
Y
RI
FGII
S
F
SL
LL
T
G
FLS
YS
GN
V
V
L
A
K
L
VSN
GW
S
NN
F
LN
A
AF
T
SAL
M
F
G
Y
F
I
GSL
TG
G
F
I
G
D
YF
GRR
R
A
F
R
I
N
L
L
I
V
G
I
A
A
TGAA
FV
PD
M
YW
LI
FF
R
F
L
M
G
T
G
M
GA
LI
M
VG
Y
A
SF
TEF
I
P
A
T
V
RG
-------
--------
-K
W
S
AR
---
L
S
F
VG
-
--------N
W
SP
ML
-
SAAI
G
V
VV
I
AFF
S
W
RI
MFLLGGIGILLAWFLSGKYFI
ESPRWL
AG
KG
Q
I
A
G
AE
CQ
L
R
E
V
--
--
-
----
EQ
QIE
R
E
K
S
IR
LPPLT
SY
QSNSKVKVIKGTFW
L
LF
KG
E
ML
RRTL
V
AITVLI
A
M
--
N
I
S
L
Y
T
I
TV
W
I
PTI
FVNS
G
I
D
V
D
K
-
-
---
S
ILMT
A
VI
M
I
GA
PVGIF
I
AA
L
I
ID
H
FPR
R
-
--
L
F
GS
T
LL
I
I--
I
AVLG
Y
I
Y
S
I
Q
TT
EWAILIYG
LV
MI
F
F
L
Y
M
Y
VC
F
A
SA
--
--
--
V
Y
I
P
EL
W
PT
HL
R
LR
G
S
GF
VN
A
V
G
RI
V
A
V
FTP
YG
VA
A
------
L
L
T
H
YG
S
I
T
V
F
M
V
LG
V
M
L
L
L
C
A
LV
L
S
-I
F
GI
ETR
K
V
SL
EEI
S
E
V
fig|316385.7.peg.1931
Escherichia coli str. K-12 substr. DH10B (6-451/452)
Q
IGARL
D
R
LPL
A
RFH
Y
RI
FGII
S
F
SL
LL
T
G
FLS
YS
GN
V
V
L
A
K
L
VSN
GW
S
NN
F
LN
A
AF
T
SAL
M
F
G
Y
F
I
GSL
TG
G
F
I
G
D
YF
GRR
R
A
F
R
I
N
L
L
I
V
G
I
A
A
TGAA
FV
PD
M
YW
LI
FF
R
F
L
M
G
T
G
M
GA
LI
M
VG
Y
A
SF
TEF
I
P
A
T
V
RG
-------
--------
-K
W
S
AR
---
L
S
F
VG
-
--------N
W
SP
ML
-
SAAI
G
V
VV
I
AFF
S
W
RI
MFLLGGIGILLAWFLSGKYFI
ESPRWL
AG
KG
Q
I
A
G
AE
CQ
L
R
E
V
--
--
-
----
EQ
QIE
R
E
K
S
IR
LPPLT
SY
QSNSKVKVIKGTFW
L
LF
KG
E
ML
RRTL
V
AITVLI
A
M
--
N
I
S
L
Y
T
I
TV
W
I
PTI
FVNS
G
I
D
V
D
K
-
-
---
S
ILMT
A
VI
M
I
GA
PVGIF
I
AA
L
I
ID
H
FPR
R
-
--
L
F
GS
T
LL
I
I--
I
AVLG
Y
I
Y
S
I
Q
TT
EWAILIYG
LV
MI
F
F
L
Y
M
Y
VC
F
A
SA
--
--
--
V
Y
I
P
EL
W
PT
HL
R
LR
G
S
GF
VN
A
V
G
RI
V
A
V
FTP
YG
VA
A
------
L
L
T
H
YG
S
I
T
V
F
M
V
LG
V
M
L
L
L
C
A
LV
L
S
-I
F
GI
ETR
K
V
SL
EEI
S
E
V
fig|511145.12.peg.1842
Escherichia coli str. K-12 substr. MG1655 (6-451/452)
Q
IGARL
D
R
LPL
A
RFH
Y
RI
FGII
S
F
SL
LL
T
G
FLS
YS
GN
V
V
L
A
K
L
VSN
GW
S
NN
F
LN
A
AF
T
SAL
M
F
G
Y
F
I
GSL
TG
G
F
I
G
D
YF
GRR
R
A
F
R
I
N
L
L
I
V
G
I
A
A
TGAA
FV
PD
M
YW
LI
FF
R
F
L
M
G
T
G
M
GA
LI
M
VG
Y
A
SF
TEF
I
P
A
T
V
RG
-------
--------
-K
W
S
AR
---
L
S
F
VG
-
--------N
W
SP
ML
-
SAAI
G
V
VV
I
AFF
S
W
RI
MFLLGGIGILLAWFLSGKYFI
ESPRWL
AG
KG
Q
I
A
G
AE
CQ
L
R
E
V
--
--
-
----
EQ
QIE
R
E
K
S
IR
LPPLT
SY
QSNSKVKVIKGTFW
L
LF
KG
E
ML
RRTL
V
AITVLI
A
M
--
N
I
S
L
Y
T
I
TV
W
I
PTI
FVNS
G
I
D
V
D
K
-
-
---
S
ILMT
A
VI
M
I
GA
PVGIF
I
AA
L
I
ID
H
FPR
R
-
--
L
F
GS
T
LL
I
I--
I
AVLG
Y
I
Y
S
I
Q
TT
EWAILIYG
LV
MI
F
F
L
Y
M
Y
VC
F
A
SA
--
--
--
V
Y
I
P
EL
W
PT
HL
R
LR
G
S
GF
VN
A
V
G
RI
V
A
V
FTP
YG
VA
A
------
L
L
T
H
YG
S
I
T
V
F
M
V
LG
V
M
L
L
L
C
A
LV
L
S
-I
F
GI
ETR
K
V
SL
EEI
S
E
V
fig|511145.6.peg.1828
Escherichia coli str. K-12 substr. MG1655 (6-451/452)
Q
IGARL
D
R
LPL
A
RFH
Y
RI
FGII
S
F
SL
LL
T
G
FLS
YS
GN
V
V
L
A
K
L
VSN
GW
S
NN
F
LN
A
AF
T
SAL
M
F
G
Y
F
I
GSL
TG
G
F
I
G
D
YF
GRR
R
A
F
R
I
N
L
L
I
V
G
I
A
A
TGAA
FV
PD
M
YW
LI
FF
R
F
L
M
G
T
G
M
GA
LI
M
VG
Y
A
SF
TEF
I
P
A
T
V
RG
-------
--------
-K
W
S
AR
---
L
S
F
VG
-
--------N
W
SP
ML
-
SAAI
G
V
VV
I
AFF
S
W
RI
MFLLGGIGILLAWFLSGKYFI
ESPRWL
AG
KG
Q
I
A
G
AE
CQ
L
R
E
V
--
--
-
----
EQ
QIE
R
E
K
S
IR
LPPLT
SY
QSNSKVKVIKGTFW
L
LF
KG
E
ML
RRTL
V
AITVLI
A
M
--
N
I
S
L
Y
T
I
TV
W
I
PTI
FVNS
G
I
D
V
D
K
-
-
---
S
ILMT
A
VI
M
I
GA
PVGIF
I
AA
L
I
ID
H
FPR
R
-
--
L
F
GS
T
LL
I
I--
I
AVLG
Y
I
Y
S
I
Q
TT
EWAILIYG
LV
MI
F
F
L
Y
M
Y
VC
F
A
SA
--
--
--
V
Y
I
P
EL
W
PT
HL
R
LR
G
S
GF
VN
A
V
G
RI
V
A
V
FTP
YG
VA
A
------
L
L
T
H
YG
S
I
T
V
F
M
V
LG
V
M
L
L
L
C
A
LV
L
S
-I
F
GI
ETR
K
V
SL
EEI
S
E
V
fig|749538.3.peg.4377
Escherichia coli MS 116-1 (6-451/452)
Q
IGARL
D
R
LPL
A
RFH
Y
RI
FGII
S
F
SL
LL
T
G
FLS
YS
GN
V
V
L
A
K
L
VSN
GW
S
NN
F
LN
A
AF
T
SAL
M
F
G
Y
F
I
GSL
TG
G
F
I
G
D
YF
GRR
R
A
F
R
I
N
L
L
I
V
G
I
A
A
TGAA
FV
PD
M
YW
LI
FF
R
F
L
M
G
T
G
M
GA
LI
M
VG
Y
A
SF
TEF
I
P
A
T
V
RG
-------
--------
-K
W
S
AR
---
L
S
F
VG
-
--------N
W
SP
ML
-
SAAI
G
V
VV
I
AFF
S
W
QI
MFLLGGIGILLAWFLSGKYFI
ESPRWL
AG
KG
Q
I
A
G
AE
CQ
L
R
E
V
--
--
-
----
EQ
QIE
R
E
K
S
IR
LPPLT
SY
QSNSKVKVIKGTFW
L
LF
KG
E
ML
RRTL
V
AITVLI
A
M
--
N
I
S
L
Y
T
I
TV
W
I
PTI
FVNS
G
I
D
V
D
K
-
-
---
S
ILMT
A
VI
M
I
GA
PVGIF
I
AA
L
I
ID
H
FPR
R
-
--
L
F
GS
T
LL
I
I--
I
AVLG
Y
I
Y
S
I
Q
TT
EWAILIYG
LV
MI
F
F
L
Y
M
Y
VC
F
A
SA
--
--
--
V
Y
I
P
EL
W
PT
HL
R
LR
G
S
GF
VN
A
V
G
RI
V
A
V
FTP
YG
VA
A
------
L
L
T
H
YG
S
I
T
V
F
M
V
LG
V
M
L
L
L
C
A
LV
L
S
-I
F
GI
ETR
K
V
SL
EEI
S
E
V
fig|331112.6.peg.1814
Escherichia coli HS (25-470/471)
Q
IG
T
RL
D
R
LPL
A
RFH
Y
RI
FGII
S
F
SL
LL
T
G
FLS
YS
GN
V
V
L
A
K
L
VSN
GW
S
NN
F
LN
A
AF
T
SAL
M
F
G
Y
F
I
GSL
TG
G
F
I
G
D
YF
GRR
R
A
F
R
I
N
L
L
I
V
G
I
A
A
TGAA
FV
PD
M
YW
LI
FF
R
F
L
M
G
T
G
M
GA
LI
M
VG
Y
A
SF
TEF
I
P
A
T
V
RG
-------
--------
-K
W
S
AR
---
L
S
F
VG
-
--------N
W
SP
ML
-
SAAI
G
V
VV
I
AFF
S
W
RI
MFLLGGIGILLAW
L
LSGKYFI
ESPRWL
AG
KG
Q
I
A
G
AE
CQ
L
R
E
V
--
--
-
----
EQ
QIE
R
E
K
S
IR
LPPLT
SY
QSNSKVKVIKGTFW
L
LF
KG
E
ML
RRTL
V
AITVLI
A
M
--
N
I
S
L
Y
T
I
TV
W
I
PTI
FVNP
G
I
D
V
D
K
-
-
---
S
ILMT
A
VI
M
I
GA
PVGIF
I
AA
L
I
ID
H
FPR
R
-
--
L
F
GS
T
LL
I
I--
I
AVLG
Y
I
Y
S
I
Q
TT
EWAILIYG
LV
MI
F
F
L
Y
M
Y
VC
F
A
SA
--
--
--
V
Y
I
P
EL
W
PT
HL
R
LR
G
S
GF
VN
A
V
G
RI
V
A
V
FTP
YG
VA
A
------
L
L
T
H
YG
S
I
T
V
F
I
V
LG
V
M
L
L
L
C
A
LV
L
S
-I
F
GI
ETR
K
V
SL
EEI
S
E
V
fig|550672.3.peg.2621
Escherichia coli B088 (6-451/452)
Q
IGARL
D
R
LPL
A
RFH
Y
RI
FGII
S
F
SL
LL
T
G
FLS
YS
GN
V
V
L
A
K
L
VSN
GW
S
NN
F
LN
A
AF
T
SAL
M
F
G
Y
F
I
GSL
TG
G
F
I
G
D
YF
GRR
R
A
F
R
I
N
L
L
I
V
G
I
A
A
TGAA
FV
PD
M
YW
LI
FF
R
F
L
M
G
T
G
M
GA
LI
M
VG
Y
A
SF
TEF
I
P
A
T
V
RG
-------
--------
-K
W
S
AR
---
L
S
F
VG
-
--------N
W
SP
ML
-
SAAI
G
V
VV
I
AFF
S
W
RI
MFLLGGIGILLAWFLSGKYFI
ESPRWL
AG
KG
Q
I
A
G
AE
SQ
L
R
E
V
--
--
-
----
EQ
QIE
R
E
K
S
IR
LPPLT
SY
QSNSKVKVIKGTFW
L
LF
KG
E
ML
RRTL
V
AITVLI
A
M
--
N
I
S
L
Y
T
I
TV
W
I
PTI
FVNS
G
I
D
V
D
K
-
-
---
S
ILMT
A
VI
M
I
GA
PVGIF
I
AA
L
I
ID
H
FPR
R
-
--
L
F
GS
T
LL
I
I--
I
AVLG
Y
I
Y
S
I
Q
TT
EWAILIYG
LV
MI
F
F
L
Y
M
Y
VC
F
A
SA
--
--
--
V
Y
I
P
EL
W
PT
HL
R
LR
G
S
GF
VN
A
V
G
RI
V
A
V
FTP
YG
VA
A
------
L
L
T
H
YG
S
I
T
V
F
M
V
LG
V
M
L
L
L
C
A
LV
L
S
-I
F
GI
ETR
K
V
SL
EEI
S
E
V
fig|585034.4.peg.1809
Escherichia coli IAI1 (6-451/452)
Q
IGARL
D
R
LPL
A
RFH
Y
RI
FGII
S
F
SL
LL
T
G
FLS
YS
GN
V
V
L
A
K
L
VSN
GW
S
NN
F
LN
A
AF
T
SAL
M
F
G
Y
F
I
GSL
TG
G
F
I
G
D
YF
GRR
R
A
F
R
I
N
L
L
I
V
G
I
A
A
TGAA
FV
PD
M
YW
LI
FF
R
F
L
M
G
T
G
M
GA
LI
M
VG
Y
A
SF
TEF
I
P
A
T
V
RG
-------
--------
-K
W
S
AR
---
L
S
F
VG
-
--------N
W
SP
ML
-
SAAI
G
V
VV
I
AFF
S
W
RI
MFLLGGIGILLAWFLSGKYFI
ESPRWL
AG
KG
Q
I
A
G
AE
SQ
L
R
E
V
--
--
-
----
EQ
QIE
R
E
K
S
IR
LPPLT
SY
QSNSKVKVIKGTFW
L
LF
KG
E
ML
RRTL
V
AITVLI
A
M
--
N
I
S
L
Y
T
I
TV
W
I
PTI
FVNS
G
I
D
V
D
K
-
-
---
S
ILMT
A
VI
M
I
GA
PVGIF
I
AA
L
I
ID
H
FPR
R
-
--
L
F
GS
T
LL
I
I--
I
AVLG
Y
I
Y
S
I
Q
TT
EWAILIYG
LV
MI
F
F
L
Y
M
Y
VC
F
A
SA
--
--
--
V
Y
I
P
EL
W
PT
HL
R
LR
G
S
GF
VN
A
V
G
RI
V
A
V
FTP
YG
VA
A
------
L
L
T
H
YG
S
I
T
V
F
M
V
LG
V
M
L
L
L
C
A
LV
L
S
-I
F
GI
ETR
K
V
SL
EEI
S
E
V
fig|585034.5.peg.1804
Escherichia coli IAI1 (6-451/452)
Q
IGARL
D
R
LPL
A
RFH
Y
RI
FGII
S
F
SL
LL
T
G
FLS
YS
GN
V
V
L
A
K
L
VSN
GW
S
NN
F
LN
A
AF
T
SAL
M
F
G
Y
F
I
GSL
TG
G
F
I
G
D
YF
GRR
R
A
F
R
I
N
L
L
I
V
G
I
A
A
TGAA
FV
PD
M
YW
LI
FF
R
F
L
M
G
T
G
M
GA
LI
M
VG
Y
A
SF
TEF
I
P
A
T
V
RG
-------
--------
-K
W
S
AR
---
L
S
F
VG
-
--------N
W
SP
ML
-
SAAI
G
V
VV
I
AFF
S
W
RI
MFLLGGIGILLAWFLSGKYFI
ESPRWL
AG
KG
Q
I
A
G
AE
SQ
L
R
E
V
--
--
-
----
EQ
QIE
R
E
K
S
IR
LPPLT
SY
QSNSKVKVIKGTFW
L
LF
KG
E
ML
RRTL
V
AITVLI
A
M
--
N
I
S
L
Y
T
I
TV
W
I
PTI
FVNS
G
I
D
V
D
K
-
-
---
S
ILMT
A
VI
M
I
GA
PVGIF
I
AA
L
I
ID
H
FPR
R
-
--
L
F
GS
T
LL
I
I--
I
AVLG
Y
I
Y
S
I
Q
TT
EWAILIYG
LV
MI
F
F
L
Y
M
Y
VC
F
A
SA
--
--
--
V
Y
I
P
EL
W
PT
HL
R
LR
G
S
GF
VN
A
V
G
RI
V
A
V
FTP
YG
VA
A
------
L
L
T
H
YG
S
I
T
V
F
M
V
LG
V
M
L
L
L
C
A
LV
L
S
-I
F
GI
ETR
K
V
SL
EEI
S
E
V
fig|595495.4.peg.2345
Escherichia coli KO11 (6-451/452)
Q
IGARL
D
R
LPL
A
RFH
Y
RI
FGII
S
F
SL
LL
T
G
FLS
YS
GN
V
V
L
A
K
L
VSN
GW
S
NN
F
LN
A
AF
T
SAL
M
F
G
Y
F
I
GSL
TG
G
F
I
G
D
YF
GRR
R
A
F
R
I
N
L
L
I
V
G
I
A
A
TGAA
FV
PD
M
YW
LI
FF
R
F
L
M
G
T
G
M
GA
LI
M
VG
Y
A
SF
TEF
I
P
A
T
V
RG
-------
--------
-K
W
S
AR
---
L
S
F
VG
-
--------N
W
SP
ML
-
SAAI
G
V
VV
I
AFF
S
W
RI
MFLLGGIGILLAWFLSGKYFI
ESPRWL
AG
KG
Q
I
A
G
AE
SQ
L
R
E
V
--
--
-
----
EQ
QIE
R
E
K
S
IR
LPPLT
SY
QSNSKVKVIKGTFW
L
LF
KG
E
ML
RRTL
V
AITVLI
A
M
--
N
I
S
L
Y
T
I
TV
W
I
PTI
FVNS
G
I
D
V
D
K
-
-
---
S
ILMT
A
VI
M
I
GA
PVGIF
I
AA
L
I
ID
H
FPR
R
-
--
L
F
GS
T
LL
I
I--
I
AVLG
Y
I
Y
S
I
Q
TT
EWAILIYG
LV
MI
F
F
L
Y
M
Y
VC
F
A
SA
--
--
--
V
Y
I
P
EL
W
PT
HL
R
LR
G
S
GF
VN
A
V
G
RI
V
A
V
FTP
YG
VA
A
------
L
L
T
H
YG
S
I
T
V
F
M
V
LG
V
M
L
L
L
C
A
LV
L
S
-I
F
GI
ETR
K
V
SL
EEI
S
E
V
fig|749545.3.peg.2703
Escherichia coli MS 182-1 (6-451/452)
Q
IGARL
D
R
LPL
A
RFH
Y
RI
FGII
S
F
SL
LL
T
G
FLS
YS
GN
V
V
L
A
K
L
VSN
GW
S
NN
F
LN
A
AF
T
SAL
M
F
G
Y
F
I
GSL
TG
G
F
I
G
D
YF
GRR
R
A
F
R
I
N
L
L
I
V
G
I
A
A
TGAA
FV
PD
M
YW
LI
FF
R
F
L
M
G
T
G
M
GA
LI
M
VG
Y
A
SF
TEF
I
P
A
T
V
RG
-------
--------
-K
W
S
AR
---
L
S
F
VG
-
--------N
W
SP
ML
-
SAAI
G
V
VV
I
AFF
S
W
RI
MFLLGGIGILLAWFLSGKYFI
ESPRWL
AG
KG
Q
I
A
G
AE
SQ
L
R
E
V
--
--
-
----
EQ
QIE
R
E
K
S
IR
LPPLT
SY
QSNSKVKVIKGTFW
L
LF
KG
E
ML
RRTL
V
AITVLI
A
M
--
N
I
S
L
Y
T
I
TV
W
I
PTI
FVNS
G
I
D
V
D
K
-
-
---
S
ILMT
A
VI
M
I
GA
PVGIF
I
AA
L
I
ID
H
FPR
R
-
--
L
F
GS
T
LL
I
I--
I
AVLG
Y
I
Y
S
I
Q
TT
EWAILIYG
LV
MI
F
F
L
Y
M
Y
VC
F
A
SA
--
--
--
V
Y
I
P
EL
W
PT
HL
R
LR
G
S
GF
VN
A
V
G
RI
V
A
V
FTP
YG
VA
A
------
L
L
T
H
YG
S
I
T
V
F
M
V
LG
V
M
L
L
L
C
A
LV
L
S
-I
F
GI
ETR
K
V
SL
EEI
S
E
V
fig|749532.3.peg.2261
Escherichia coli MS 78-1 (6-451/452)
Q
IGARL
D
R
LPL
A
RFH
Y
RI
FGII
S
F
SL
LL
T
G
FLS
YS
GN
V
V
L
A
K
L
VSN
GW
S
NN
F
LN
A
AF
T
SAL
M
F
G
Y
F
I
GSL
TG
G
F
I
G
D
YF
GRR
R
A
F
R
I
N
L
L
I
V
G
I
A
A
TGAA
FV
PD
M
YW
LI
FF
R
F
L
M
G
T
G
M
GA
LI
M
VG
Y
A
SF
TEF
I
P
A
T
V
RG
-------
--------
-K
W
S
AR
---
L
S
F
VG
-
--------N
W
SP
ML
-
SAAI
G
V
VV
I
AFF
S
W
RI
MFLLGGIGILLAWFLSGKYFI
ESPRWL
AG
KG
Q
I
A
G
AE
SQ
L
R
E
V
--
--
-
----
EQ
QIE
R
E
K
S
IR
LPPLT
SY
QSNSKVKVIKGTFW
L
LF
KG
E
ML
RRTL
V
AITVLI
A
M
--
N
I
S
L
Y
T
I
TV
W
I
PTI
FVNS
G
I
D
V
D
K
-
-
---
S
ILMT
A
VI
M
I
GA
PVGIF
I
AA
L
I
ID
H
FPR
R
-
--
L
F
GS
T
LL
I
I--
I
AVLG
Y
I
Y
S
I
Q
TT
EWAILIYG
LV
MI
F
F
L
Y
M
Y
VC
F
A
SA
--
--
--
V
Y
I
P
EL
W
PT
HL
R
LR
G
S
GF
VN
A
V
G
RI
V
A
V
FTP
YG
VA
A
------
L
L
T
H
YG
S
I
T
V
F
M
V
LG
V
M
L
L
L
C
A
LV
L
S
-I
F
GI
ETR
K
V
SL
EEI
S
E
V
fig|566546.4.peg.1927
Escherichia coli W (6-451/452)
Q
IGARL
D
R
LPL
A
RFH
Y
RI
FGII
S
F
SL
LL
T
G
FLS
YS
GN
V
V
L
A
K
L
VSN
GW
S
NN
F
LN
A
AF
T
SAL
M
F
G
Y
F
I
GSL
TG
G
F
I
G
D
YF
GRR
R
A
F
R
I
N
L
L
I
V
G
I
A
A
TGAA
FV
PD
M
YW
LI
FF
R
F
L
M
G
T
G
M
GA
LI
M
VG
Y
A
SF
TEF
I
P
A
T
V
RG
-------
--------
-K
W
S
AR
---
L
S
F
VG
-
--------N
W
SP
ML
-
SAAI
G
V
VV
I
AFF
S
W
RI
MFLLGGIGILLAWFLSGKYFI
ESPRWL
AG
KG
Q
I
A
G
AE
SQ
L
R
E
V
--
--
-
----
EQ
QIE
R
E
K
S
IR
LPPLT
SY
QSNSKVKVIKGTFW
L
LF
KG
E
ML
RRTL
V
AITVLI
A
M
--
N
I
S
L
Y
T
I
TV
W
I
PTI
FVNS
G
I
D
V
D
K
-
-
---
S
ILMT
A
VI
M
I
GA
PVGIF
I
AA
L
I
ID
H
FPR
R
-
--
L
F
GS
T
LL
I
I--
I
AVLG
Y
I
Y
S
I
Q
TT
EWAILIYG
LV
MI
F
F
L
Y
M
Y
VC
F
A
SA
--
--
--
V
Y
I
P
EL
W
PT
HL
R
LR
G
S
GF
VN
A
V
G
RI
V
A
V
FTP
YG
VA
A
------
L
L
T
H
YG
S
I
T
V
F
M
V
LG
V
M
L
L
L
C
A
LV
L
S
-I
F
GI
ETR
K
V
SL
EEI
S
E
V
fig|344610.7.peg.5427
Escherichia coli 53638 (29-474/475)
Q
IGARL
D
R
LPL
A
RFH
Y
RI
FGII
S
F
SL
LL
T
G
FLS
YS
GN
V
V
L
A
K
L
VSN
GW
S
NN
F
LN
A
AF
T
SAL
M
F
G
Y
F
I
GSL
TG
G
F
I
G
D
YF
GRR
R
A
F
R
I
N
L
L
I
V
G
I
A
A
TGAA
FV
PD
M
YW
LI
FF
R
F
L
M
G
T
G
M
GA
LI
M
VG
Y
A
SF
TEF
I
P
A
T
V
RG
-------
--------
-K
W
S
AR
---
L
S
F
VG
-
--------N
W
SP
ML
-
SAAI
G
V
VV
I
AFF
S
W
RI
MFLLGGIGILLAW
L
LSGKYFI
ESPRWL
AG
KG
Q
I
A
G
AE
CQ
L
R
E
V
--
--
-
----
EQ
QIE
R
E
K
S
IR
LPPLT
SY
QSNSKVKVIKGTFW
L
LF
KG
E
ML
RRTL
V
AITVLI
A
M
--
N
I
S
L
Y
T
I
TV
W
I
PTI
FVNS
G
I
D
V
D
K
-
-
---
S
ILMT
A
VI
M
I
GA
PVGIF
I
AA
L
I
ID
H
FPR
R
-
--
L
F
GS
T
LL
I
I--
I
AVLG
Y
I
Y
S
I
Q
TT
EWAILIYG
LV
MI
F
F
L
Y
M
Y
VC
F
A
SA
--
--
--
V
Y
I
P
EL
W
PT
HL
R
LR
G
S
GF
VN
A
V
G
RI
V
A
V
FTP
YG
VA
A
------
L
L
T
H
YG
S
I
T
V
F
I
V
LG
V
M
L
L
L
C
A
LV
L
S
-I
F
GI
ETR
K
V
SL
EEI
S
E
V
fig|344610.3.peg.2372
Escherichia coli 53638 (6-451/452)
Q
IGARL
D
R
LPL
A
RFH
Y
RI
FGII
S
F
SL
LL
T
G
FLS
YS
GN
V
V
L
A
K
L
VSN
GW
S
NN
F
LN
A
AF
T
SAL
M
F
G
Y
F
I
GSL
TG
G
F
I
G
D
YF
GRR
R
A
F
R
I
N
L
L
I
V
G
I
A
A
TGAA
FV
PD
M
YW
LI
FF
R
F
L
M
G
T
G
M
GA
LI
M
VG
Y
A
SF
TEF
I
P
A
T
V
RG
-------
--------
-K
W
S
AR
---
L
S
F
VG
-
--------N
W
SP
ML
-
SAAI
G
V
VV
I
AFF
S
W
RI
MFLLGGIGILLAW
L
LSGKYFI
ESPRWL
AG
KG
Q
I
A
G
AE
CQ
L
R
E
V
--
--
-
----
EQ
QIE
R
E
K
S
IR
LPPLT
SY
QSNSKVKVIKGTFW
L
LF
KG
E
ML
RRTL
V
AITVLI
A
M
--
N
I
S
L
Y
T
I
TV
W
I
PTI
FVNS
G
I
D
V
D
K
-
-
---
S
ILMT
A
VI
M
I
GA
PVGIF
I
AA
L
I
ID
H
FPR
R
-
--
L
F
GS
T
LL
I
I--
I
AVLG
Y
I
Y
S
I
Q
TT
EWAILIYG
LV
MI
F
F
L
Y
M
Y
VC
F
A
SA
--
--
--
V
Y
I
P
EL
W
PT
HL
R
LR
G
S
GF
VN
A
V
G
RI
V
A
V
FTP
YG
VA
A
------
L
L
T
H
YG
S
I
T
V
F
I
V
LG
V
M
L
L
L
C
A
LV
L
S
-I
F
GI
ETR
K
V
SL
EEI
S
E
V
fig|316401.4.peg.2064
Escherichia coli ETEC H10407 (6-451/452)
Q
IGARL
D
R
LPL
A
RFH
Y
RI
FGII
S
F
SL
LL
T
G
FLS
YS
GN
V
V
L
A
K
L
VSN
GW
S
NN
F
LN
A
AF
T
SAL
M
F
G
Y
F
I
GSL
TG
G
F
I
G
D
YF
GRR
R
A
F
R
I
N
L
L
I
V
G
I
A
A
TGAA
FV
PD
M
YW
LI
FF
R
F
L
M
G
T
G
M
GA
LI
M
VG
Y
A
SF
TEF
I
P
A
T
V
RG
-------
--------
-K
W
S
AR
---
L
S
F
VG
-
--------N
W
SP
ML
-
SAAI
G
V
VV
I
AFF
S
W
RI
MFLLGGIGILLAW
L
LSGKYFI
ESPRWL
AG
KG
Q
I
A
G
AE
CQ
L
R
E
V
--
--
-
----
EQ
QIE
R
E
K
S
IR
LPPLT
SY
QSNSKVKVIKGTFW
L
LF
KG
E
ML
RRTL
V
AITVLI
A
M
--
N
I
S
L
Y
T
I
TV
W
I
PTI
FVNS
G
I
D
V
D
K
-
-
---
S
ILMT
A
VI
M
I
GA
PVGIF
I
AA
L
I
ID
H
FPR
R
-
--
L
F
GS
T
LL
I
I--
I
AVLG
Y
I
Y
S
I
Q
TT
EWAILIYG
LV
MI
F
F
L
Y
M
Y
VC
F
A
SA
--
--
--
V
Y
I
P
EL
W
PT
HL
R
LR
G
S
GF
VN
A
V
G
RI
V
A
V
FTP
YG
VA
A
------
L
L
T
H
YG
S
I
T
V
F
I
V
LG
V
M
L
L
L
C
A
LV
L
S
-I
F
GI
ETR
K
V
SL
EEI
S
E
V
fig|331112.3.peg.1746
Escherichia coli HS (6-451/452)
Q
IG
T
RL
D
R
LPL
A
RFH
Y
RI
FGII
S
F
SL
LL
T
G
FLS
YS
GN
V
V
L
A
K
L
VSN
GW
S
NN
F
LN
A
AF
T
SAL
M
F
G
Y
F
I
GSL
TG
G
F
I
G
D
YF
GRR
R
A
F
R
I
N
L
L
I
V
G
I
A
A
TGAA
FV
PD
M
YW
LI
FF
R
F
L
M
G
T
G
M
GA
LI
M
VG
Y
A
SF
TEF
I
P
A
T
V
RG
-------
--------
-K
W
S
AR
---
L
S
F
VG
-
--------N
W
SP
ML
-
SAAI
G
V
VV
I
AFF
S
W
RI
MFLLGGIGILLAW
L
LSGKYFI
ESPRWL
AG
KG
Q
I
A
G
AE
CQ
L
R
E
V
--
--
-
----
EQ
QIE
R
E
K
S
IR
LPPLT
SY
QSNSKVKVIKGTFW
L
LF
KG
E
ML
RRTL
V
AITVLI
A
M
--
N
I
S
L
Y
T
I
TV
W
I
PTI
FVNP
G
I
D
V
D
K
-
-
---
S
ILMT
A
VI
M
I
GA
PVGIF
I
AA
L
I
ID
H
FPR
R
-
--
L
F
GS
T
LL
I
I--
I
AVLG
Y
I
Y
S
I
Q
TT
EWAILIYG
LV
MI
F
F
L
Y
M
Y
VC
F
A
SA
--
--
--
V
Y
I
P
EL
W
PT
HL
R
LR
G
S
GF
VN
A
V
G
RI
V
A
V
FTP
YG
VA
A
------
L
L
T
H
YG
S
I
T
V
F
I
V
LG
V
M
L
L
L
C
A
LV
L
S
-I
F
GI
ETR
K
V
SL
EEI
S
E
V
fig|331111.12.peg.2269
Escherichia coli E24377A (6-451/452)
Q
IGARL
D
R
LPL
A
RFH
Y
RI
FGII
S
F
SL
LL
T
G
FLS
YS
GN
V
V
L
A
K
L
VSN
GW
S
NN
F
LN
A
AF
T
SAL
M
F
G
Y
F
I
GSL
TG
G
F
I
G
D
YF
GRR
R
A
F
R
I
N
L
L
I
V
G
I
A
A
TGAA
FV
PD
M
YW
LI
FF
R
F
L
M
G
T
G
M
GA
LI
M
VG
Y
A
SF
TEF
I
P
A
T
V
RG
-------
--------
-K
W
S
AR
---
L
S
F
VG
-
--------N
W
SP
ML
-
SAAI
G
V
VV
I
AFF
S
W
RI
MFLLGGIGILLAWFLSGK
C
FI
ESPRWL
AG
KG
Q
I
A
G
AE
SQ
L
R
E
V
--
--
-
----
EQ
QIE
R
E
K
S
IR
LPPLT
SY
QSNSKVKVIKGTFW
L
LF
KG
E
ML
RRTL
V
AITVLI
A
M
--
N
I
S
L
Y
T
I
TV
W
I
PTI
FVNS
G
I
D
V
D
K
-
-
---
S
ILMT
A
VI
M
I
GA
PVGIF
I
AA
L
I
ID
H
FPR
R
-
--
L
F
GS
T
LL
I
I--
I
AVLG
Y
I
Y
S
I
Q
TT
EWAILIYG
LV
MI
F
F
L
Y
M
Y
VC
F
A
SA
--
--
--
V
Y
I
P
EL
W
PT
HL
R
LR
G
S
GF
VN
A
V
G
RI
V
A
V
FTP
YG
VA
A
------
L
L
T
H
YG
S
I
T
V
F
M
V
LG
V
M
L
L
L
C
A
LV
L
S
-I
F
GI
ETR
K
V
SL
EEI
S
E
V
fig|331111.3.peg.4412
Escherichia coli E24377A (6-451/452)
Q
IGARL
D
R
LPL
A
RFH
Y
RI
FGII
S
F
SL
LL
T
G
FLS
YS
GN
V
V
L
A
K
L
VSN
GW
S
NN
F
LN
A
AF
T
SAL
M
F
G
Y
F
I
GSL
TG
G
F
I
G
D
YF
GRR
R
A
F
R
I
N
L
L
I
V
G
I
A
A
TGAA
FV
PD
M
YW
LI
FF
R
F
L
M
G
T
G
M
GA
LI
M
VG
Y
A
SF
TEF
I
P
A
T
V
RG
-------
--------
-K
W
S
AR
---
L
S
F
VG
-
--------N
W
SP
ML
-
SAAI
G
V
VV
I
AFF
S
W
RI
MFLLGGIGILLAWFLSGK
C
FI
ESPRWL
AG
KG
Q
I
A
G
AE
SQ
L
R
E
V
--
--
-
----
EQ
QIE
R
E
K
S
IR
LPPLT
SY
QSNSKVKVIKGTFW
L
LF
KG
E
ML
RRTL
V
AITVLI
A
M
--
N
I
S
L
Y
T
I
TV
W
I
PTI
FVNS
G
I
D
V
D
K
-
-
---
S
ILMT
A
VI
M
I
GA
PVGIF
I
AA
L
I
ID
H
FPR
R
-
--
L
F
GS
T
LL
I
I--
I
AVLG
Y
I
Y
S
I
Q
TT
EWAILIYG
LV
MI
F
F
L
Y
M
Y
VC
F
A
SA
--
--
--
V
Y
I
P
EL
W
PT
HL
R
LR
G
S
GF
VN
A
V
G
RI
V
A
V
FTP
YG
VA
A
------
L
L
T
H
YG
S
I
T
V
F
M
V
LG
V
M
L
L
L
C
A
LV
L
S
-I
F
GI
ETR
K
V
SL
EEI
S
E
V
fig|670897.3.peg.2652
Escherichia coli 2362-75 (6-447/448)
Q
IGARL
D
R
LPL
A
RFH
Y
RI
FGII
S
F
SL
LL
T
G
FLS
YS
GN
V
V
L
A
K
L
VSN
GW
S
NN
F
LN
A
AF
T
SAL
M
F
G
Y
F
I
GSL
TG
G
F
I
G
D
YF
GRR
R
A
F
R
I
N
L
L
I
V
----
TGAA
FV
PD
M
YW
LI
FF
R
F
L
M
G
T
G
M
GA
LI
M
VG
Y
A
SF
TEF
I
P
A
T
V
RG
-------
--------
-K
W
S
AR
---
L
S
F
VG
-
--------N
W
SP
ML
-
SAAI
G
V
VV
I
AFF
S
W
RI
MFLLGGIGILLAWFLSGKYFI
ESPRWL
AG
KG
Q
I
A
G
AE
SQ
L
R
E
V
--
--
-
----
EQ
QIE
R
E
K
S
IR
LPPLT
LN
QSNSKVKVIKGTFW
L
LF
KG
E
ML
RRTL
V
AITVLI
A
M
--
N
I
S
L
Y
T
I
TV
W
I
PTI
FVNS
G
I
D
V
D
K
-
-
---
S
ILMT
A
VI
M
I
GA
PVGIF
I
AA
L
I
ID
H
FPR
R
-
--
L
F
GS
A
LL
I
I--
I
AVLG
Y
I
Y
S
I
Q
TT
EWAILIYG
LV
MI
F
F
L
Y
M
Y
VC
F
A
SA
--
--
--
V
Y
I
P
EL
W
PT
HL
R
LR
G
S
GF
VN
A
V
G
RI
V
A
V
FTP
YG
VA
A
------
L
L
T
H
YG
S
I
T
V
F
M
V
LG
V
M
L
V
L
C
A
LV
L
S
-I
F
GI
ETR
K
V
SL
EEI
S
E
V
Consen1
Primary consensus
MQpsrnfDdLplsrfH
RI
sg
lldGyvl
igval
qLtpa
l
f
g
g
l
GlFvGsl
GyIsD
GRrk
F
id
l
igvas
Fv
p
Li
R
LiGigiGady
vg
s
tEFsp
r
Rg
--------
W
vg
as
vG
-
WrwmL
SAAip
llI
rw
--------------------
pESPRWLlrkGr
aeae
m
k
fg
v
Eq
t
k
ir
-----
--------------
LF
r
rrtlf
c
--
vIp
f
Iytw
PtI
Gl
v
k
a
svvisa
mlGa
-----
i
ll
h
rr
L
GS
llm
laVlg
ips
g
--------
Lvvm
F
-
vy
f
sa
nl
lyp
ElfPTdiR
gvGf
alsRiga
vst
lp
------
ln
yG
-
i
vtmllga
i
L
glvis
fapETr
msL
snvTIRGQRMG
Consen2
Secondary consensus
igarl
r
kf
si
ff
ftt
fls
gnyvi
k
vsn
s
d
a
t
m
y
ts
g
qr
f
i
vt
ia
a
m
l
m
tv
gli
ia
a
is
t
a
ar
ld
a
h
spl
lg
vv
sf
mfllggigillawflsgkyfi
agq
q
kgch
--
-
v
r
-
fklpplt
qsnskvkvikgtfw
e
pfvav
a
n
s
y
tvf
q
i
-
e
-
n
l
i
cpvgifl
m
n
h
-
am
iv
ma
lyd
q
ewailiyg
t
y
f
t
gg
--
li
sw
hl
as
v
s
g
lvt
ftp
va
i
w
sm
nflvmlv
afl
t
wgi
k
p
gem
Consensus 1
(when a gap)
Conservative difference
Consensus 2
(when a gap)
Nonconservative diff.
Other character