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fig|562.376.peg.1283
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fig|585055.6.peg.38
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fig|585055.8.peg.38
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fig|344601.3.peg.4199
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fig|344601.5.peg.4422
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fig|550676.3.peg.4701
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fig|340184.3.peg.4014
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fig|340184.6.peg.4198
Escherichia coli B7A
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fig|331112.3.peg.37
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fig|331112.6.peg.40
Escherichia coli HS
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fig|679207.4.peg.1072
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fig|749545.3.peg.2073
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fig|749532.3.peg.4232
Escherichia coli MS 78-1
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fig|550672.3.peg.4310
Escherichia coli B088 (6-522/522)
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AL
--
PA
DD
G
VS
SFTQ
LK
N
-------------------
Q
QP
AT
L
CY
A
PPL
S
T
DD
T
A
E
ILFTSGTT
S
R
PKGV
V
I
TH
Y
N
-
L
RFAGY
Y
S
A
-
-
---
WQ
CALRDD
DVY
LTV
M
P
A
F
H
I
DC
QCTAAM
A
A
F
SA
GAT
F
VL
V
E
KY
----
SA
R
A
FWGQ
V
Q
K
Y
R
A
T
----
IT
ECI
P
MM
IR
T
LM
V
QP
LS
A
NDQQH
RL
R
E
VM
F
Y
L
----
----N
LS
E
Q
EKDAF
C
ER
F
S
V
R
---
LL
TS
YG
M
TET
----
IV
G
IIG
D
R
PG
DK
R
RWP
-
S
I
GRA
G
F
CY
E
AE
I
R
DD
HNR
PLP
A
G
E
L
GE
IC
I
KG
V
---
P
G
K
T
I
F
-------
KE
YF
LN
P
KA
TAK
V
L
EAD
GW
L
H
T
GD
TG
Y
RDE
E
G
F
FY
FVD
R
RC
N
M
I
K
RGGEN
V
S
CV
E
L
E
N
I
I
AT
HPKI
Q
D
I
V
VVGI
K
D
S
I
R
D
EAI
K
A
F
VVLN
E
-
GE
T
LS
E
EE
F
--
F
C
-
F
C
EQ
N
M
AK
F
K
V
P
SY
L
EIR
K
D
LPR
N
C
SGKI
----
I
RKNLK
fig|656393.3.peg.647
Escherichia coli H299
MDIIGGQHLRQMWDDLADVYG
H
KTA
L
I
C
E
-
SS
S
G
VVNR
YSY
L
EL
N
QEIN
R
T
AN
LF
Y
T
LGI
R
KGD
K
VA
LH
L
D
NC
PEF
I
F
CW
FGL
AKIGA
I
M
VPI
NARLLR
EE
S
T
W
I
L
QN
SQA
C
L
LV
TS
AQ
F
Y
P
-
MYQ
Q
IQ
--------
QE
DAS
QLR
H
I
C
L
---
T
D
M
AL
--
PA
DD
G
VS
SFTQ
LK
N
-------------------
Q
QP
AT
L
CY
A
PPL
S
T
DD
T
A
E
ILFTSGTT
S
R
PKGV
V
I
TH
Y
N
-
L
RFAGY
Y
S
A
-
-
---
WQ
CALRDD
DVY
LTV
M
P
A
F
H
I
DC
QCTAAM
A
A
F
SA
GAT
F
VL
V
E
KY
----
SA
R
A
FWGQ
V
QN
Y
R
A
T
----
IT
ECI
P
MM
IR
T
LM
V
QP
LS
A
NDRQH
C
L
R
E
VM
F
Y
L
----
----N
LS
E
Q
EKDAF
C
ER
F
S
V
R
---
LL
TS
YG
M
TET
----
IV
G
IIG
D
R
PG
DK
R
RWP
-
S
I
GRA
G
F
CY
E
AE
I
R
DD
HNR
PLP
A
G
E
L
GE
IC
I
KG
V
---
P
G
K
T
I
F
-------
KE
YF
LN
P
KA
TAK
V
L
EAD
GW
L
H
T
GD
TG
Y
RDE
E
G
F
FY
FVD
R
RC
N
M
I
K
RGGEN
V
S
CV
E
L
E
N
I
I
AT
HPKI
Q
D
I
V
VVGI
K
D
S
I
R
D
EAI
K
A
F
VVLN
E
-
GE
T
LS
E
EE
F
--
F
C
-
F
C
EQ
N
M
AK
F
K
V
P
SY
L
EIR
K
D
LPR
N
C
SGKI
----
I
RKNLK
fig|481805.3.peg.3885
Escherichia coli ATCC 8739 (2-505/505)
DDLADVYG
H
KTA
L
I
C
E
-
SS
GG
VVNR
YSY
L
EL
N
QEIN
R
T
AN
LF
Y
T
LGI
R
KGD
K
VA
LH
L
D
NC
PEF
I
F
CW
FGL
AKIGA
I
M
VPI
NARLLC
EE
S
AW
I
L
QN
SQA
C
L
LV
TS
AQ
F
Y
P
-
MYQ
Q
IQ
--------
QE
DAT
QLR
H
I
C
L
---
T
D
V
AL
--
PA
DD
G
VS
SFTQ
LK
N
-------------------
Q
QP
AT
L
CY
A
PPL
S
T
DD
T
A
E
ILFTSGTT
S
R
PKGV
V
I
TH
Y
N
-
L
RFAGY
Y
S
A
-
-
---
WQ
CALRDD
DVY
LTV
M
P
A
F
H
I
DC
QCTAAM
A
A
F
SA
GAT
F
VL
V
E
KY
----
SA
R
A
FWGQ
V
Q
K
Y
R
A
T
----
V
T
ECI
P
MM
IR
T
LM
V
QP
PS
A
NDQQH
RL
R
E
VM
F
Y
L
----
----N
LS
E
Q
EKDAF
C
ER
F
G
V
R
---
LL
TS
YG
M
TET
----
IV
G
IIG
D
R
PG
DK
R
RWP
-
S
I
GR
V
G
F
CY
E
AE
I
R
DD
HNR
PLP
A
G
E
I
GE
IC
I
KG
I
---
P
G
K
T
I
F
-------
KE
YF
LN
P
QA
TAK
V
L
EAD
GW
L
H
T
GD
TG
Y
RDE
E
G
F
FY
FVD
R
RC
N
M
I
K
RGGEN
V
S
CV
E
L
E
N
I
I
AA
HPKI
Q
D
I
V
VVGI
K
D
S
I
R
D
EAI
K
A
F
VVLN
E
-
GE
T
LS
E
EE
F
--
F
R
-
F
C
EQ
N
M
AK
F
K
V
P
SY
L
EIR
K
D
LPR
N
C
SGKI
----
I
RKNLK
fig|481805.6.peg.3865
Escherichia coli ATCC 8739 (2-505/505)
DDLADVYG
H
KTA
L
I
C
E
-
SS
GG
VVNR
YSY
L
EL
N
QEIN
R
T
AN
LF
Y
T
LGI
R
KGD
K
VA
LH
L
D
NC
PEF
I
F
CW
FGL
AKIGA
I
M
VPI
NARLLC
EE
S
AW
I
L
QN
SQA
C
L
LV
TS
AQ
F
Y
P
-
MYQ
Q
IQ
--------
QE
DAT
QLR
H
I
C
L
---
T
D
V
AL
--
PA
DD
G
VS
SFTQ
LK
N
-------------------
Q
QP
AT
L
CY
A
PPL
S
T
DD
T
A
E
ILFTSGTT
S
R
PKGV
V
I
TH
Y
N
-
L
RFAGY
Y
S
A
-
-
---
WQ
CALRDD
DVY
LTV
M
P
A
F
H
I
DC
QCTAAM
A
A
F
SA
GAT
F
VL
V
E
KY
----
SA
R
A
FWGQ
V
Q
K
Y
R
A
T
----
V
T
ECI
P
MM
IR
T
LM
V
QP
PS
A
NDQQH
RL
R
E
VM
F
Y
L
----
----N
LS
E
Q
EKDAF
C
ER
F
G
V
R
---
LL
TS
YG
M
TET
----
IV
G
IIG
D
R
PG
DK
R
RWP
-
S
I
GR
V
G
F
CY
E
AE
I
R
DD
HNR
PLP
A
G
E
I
GE
IC
I
KG
I
---
P
G
K
T
I
F
-------
KE
YF
LN
P
QA
TAK
V
L
EAD
GW
L
H
T
GD
TG
Y
RDE
E
G
F
FY
FVD
R
RC
N
M
I
K
RGGEN
V
S
CV
E
L
E
N
I
I
AA
HPKI
Q
D
I
V
VVGI
K
D
S
I
R
D
EAI
K
A
F
VVLN
E
-
GE
T
LS
E
EE
F
--
F
R
-
F
C
EQ
N
M
AK
F
K
V
P
SY
L
EIR
K
D
LPR
N
C
SGKI
----
I
RKNLK
fig|749544.3.peg.2653
Escherichia coli MS 175-1
MWDDLADVYG
H
KTA
L
I
C
E
-
SS
GG
VVNR
YSY
L
EL
N
QEIN
R
T
AN
LF
Y
T
LGI
R
KGD
K
VA
LH
L
D
NC
PEF
I
F
CW
FGL
AKIGA
I
M
VPI
NARLLR
EE
S
T
W
I
L
QN
SQA
C
L
LV
TS
AQ
F
Y
P
-
MYQ
Q
IQ
--------
QE
DAS
QLR
H
I
C
L
---
T
D
M
AL
--
PA
DD
G
VS
SFTQ
LK
N
-------------------
Q
QP
AT
L
CY
A
PPL
S
T
DD
T
A
E
ILFTSGTT
S
R
S
KGV
V
I
TH
Y
N
-
L
RFAGY
Y
S
A
-
-
---
WQ
CALRDD
DVY
LTV
M
P
A
F
H
I
DC
QCTAAM
A
A
F
SA
GAT
F
VL
V
E
KY
----
SA
R
A
FWGQ
V
Q
K
Y
R
A
T
----
IT
ECI
P
MM
IR
T
LM
V
QP
PS
A
NDRQH
C
L
R
E
VM
F
Y
L
----
----N
LS
E
Q
EKDAF
C
E
C
F
S
V
R
---
LL
TS
YG
M
TET
----
IV
G
IIG
D
R
PG
DK
R
RWP
-
S
I
GRA
G
F
CY
E
AE
I
R
DD
HNR
PLP
A
G
E
L
GE
IC
I
KG
V
---
P
G
K
T
I
F
-------
KE
YF
LN
P
KA
TAK
V
L
EAD
GW
L
H
T
GD
TG
Y
RDE
E
G
F
FY
FVD
R
RC
N
M
I
K
RGGEN
V
S
CV
E
L
E
N
I
I
AA
HPKI
Q
D
I
V
VVGI
K
D
S
I
R
D
EAI
K
A
F
VVLN
E
-
GE
T
LS
E
EE
F
--
F
R
-
F
C
EQ
N
M
AK
F
K
V
P
SY
L
EIR
K
D
LPR
N
C
SGKI
----
I
RKNLK
fig|749538.3.peg.2043
Escherichia coli MS 116-1
MWDDLADVYG
H
KTA
L
I
C
E
-
SS
GG
VVNR
YSY
L
EL
N
QEIN
R
T
AN
LF
Y
T
LGI
R
KGD
K
VA
LH
L
D
NC
PEF
I
F
CW
FGL
AKIGA
I
M
VPI
NARLLR
EE
S
T
W
I
L
QN
SQA
C
L
LV
TS
AQ
F
Y
P
-
MYQ
Q
IQ
--------
QE
DAS
QLR
H
I
C
L
---
T
D
M
AL
--
PA
DD
G
VS
SFTQ
LK
N
-------------------
Q
H
P
PT
L
CY
A
PPL
S
T
DD
T
A
E
ILFTSGTT
S
R
S
KGV
V
I
TH
Y
N
-
L
RFAGY
Y
S
A
-
-
---
WQ
CALRDD
DVY
LTV
M
P
A
F
H
I
DC
QCTAAM
A
A
F
SA
GAT
F
VL
V
E
KY
----
SA
R
A
FWGQ
V
Q
K
Y
R
A
T
----
IT
ECI
P
MM
IR
T
LM
V
QP
PS
A
NDRQH
C
L
R
E
VM
F
Y
L
----
----N
LS
E
Q
EKDAF
C
E
C
F
S
V
R
---
LL
TS
YG
M
TET
----
IV
G
IIG
D
R
PG
DK
R
RWP
-
S
I
GRA
G
F
CY
E
AE
I
R
DD
HNR
PLP
A
G
E
L
GE
IC
I
KG
V
---
P
G
K
T
I
F
-------
KE
YF
LN
P
KA
TAK
V
L
EAD
GW
L
H
T
GD
TG
Y
RDE
E
G
F
FY
FVD
R
RC
N
M
I
K
RGGEN
V
S
CV
E
L
E
N
I
I
AA
HPKI
Q
D
I
V
VVGI
K
D
S
I
R
D
EAI
K
A
F
VVLN
E
-
GE
T
LS
E
EE
F
--
F
R
-
F
C
EQ
N
M
AK
F
K
V
P
SY
L
EIR
K
D
LPR
N
C
SGKI
----
I
RKNLK
fig|585057.4.peg.1418
Escherichia coli IAI39 (20-535/546)
LW
G
DAS
L
ADY
W
QQT
A
RAMP
DK
I
A
V
V
D
N
-
HG
AS
----
Y
T
Y
S
A
L
D
HAAS
C
L
AN
WM
L
T
K
GI
E
S
GD
R
I
A
FQ
LP
GW
C
EF
T
V
IY
LAC
L
KIGAV
S
VP
L
LPSWRE
A
E
L
V
W
V
L
NK
C
QA
K
M
F-
--
--
F
A
P
T
LFK
Q
TR
PVDLILPL
Q
N
QLP
QL
Q
Q
I
V
G
---
VD
K
LA
--
PA
TS
S
L
S
LSQI
IA
D
-------------------
N
T
P
--
L
TT
A
ITV
H
G
D
E
L
A
A
V
LFTSGT
E
G
L
PKGV
M
L
TH
N
N
I
L
ASERA
Y
C
A
R
L
NLT
WQ
------
DV
F
MMP
AP
L
GH
A
TG
FLHGVT
APF
LI
GA
R
S
VL
L
D
IF
----
TP
A
A
CLAL
L
E
Q
Q
R
C
T
CMLGA
T
PFV
Y
DL
LN
L
L
E
K
QP
AD
-
-----
-
LS
A
LRF
L
L
CGGT
TIPKK
V
A
R
E
-----
C
QQ
R
G
I
K
---
LL
SV
YG
S
TE
S
SPHA
V
V
N
L
--
N
D
P
L
-P
R
FMH
-
T
D
G
Y
A
A
A
GVE
IK
V
VDD
ARK
T
LP
P
G
C
EGE
--
-
EA
S
---
R
G
P
N
V
F
-------
MG
YF
DE
P
EL
TA
R
A
L
DEE
GWY
Y
SGD
LC
R
M
DE
A
GY
IK
ITGR
KK
D
I
I
V
RGGEN
I
S
SR
E
V
E
D
IL
LQ
HPKI
H
DA
C
VV
AM
PD
E
R
L
GE
RS
C
AYVVL
K
A
PHH
S
LS
L
EE
V
--
V
A
F
F
S
RK
R
V
AK
Y
K
Y
P
EH
I
VVI
E
K
LPRT
A
SGKI
QKFL
LRK
DI
fig|585057.6.peg.1418
Escherichia coli IAI39 (20-535/546)
LW
G
DAS
L
ADY
W
QQT
A
RAMP
DK
I
A
V
V
D
N
-
HG
AS
----
Y
T
Y
S
A
L
D
HAAS
C
L
AN
WM
L
T
K
GI
E
S
GD
R
I
A
FQ
LP
GW
C
EF
T
V
IY
LAC
L
KIGAV
S
VP
L
LPSWRE
A
E
L
V
W
V
L
NK
C
QA
K
M
F-
--
--
F
A
P
T
LFK
Q
TR
PVDLILPL
Q
N
QLP
QL
Q
Q
I
V
G
---
VD
K
LA
--
PA
TS
S
L
S
LSQI
IA
D
-------------------
N
T
P
--
L
TT
A
ITV
H
G
D
E
L
A
A
V
LFTSGT
E
G
L
PKGV
M
L
TH
N
N
I
L
ASERA
Y
C
A
R
L
NLT
WQ
------
DV
F
MMP
AP
L
GH
A
TG
FLHGVT
APF
LI
GA
R
S
VL
L
D
IF
----
TP
A
A
CLAL
L
E
Q
Q
R
C
T
CMLGA
T
PFV
Y
DL
LN
L
L
E
K
QP
AD
-
-----
-
LS
A
LRF
L
L
CGGT
TIPKK
V
A
R
E
-----
C
QQ
R
G
I
K
---
LL
SV
YG
S
TE
S
SPHA
V
V
N
L
--
N
D
P
L
-P
R
FMH
-
T
D
G
Y
A
A
A
GVE
IK
V
VDD
ARK
T
LP
P
G
C
EGE
--
-
EA
S
---
R
G
P
N
V
F
-------
MG
YF
DE
P
EL
TA
R
A
L
DEE
GWY
Y
SGD
LC
R
M
DE
A
GY
IK
ITGR
KK
D
I
I
V
RGGEN
I
S
SR
E
V
E
D
IL
LQ
HPKI
H
DA
C
VV
AM
PD
E
R
L
GE
RS
C
AYVVL
K
A
PHH
S
LS
L
EE
V
--
V
A
F
F
S
RK
R
V
AK
Y
K
Y
P
EH
I
VVI
E
K
LPRT
A
SGKI
QKFL
LRK
DI
fig|340184.3.peg.2929
Escherichia coli B7A (38-553/566)
LW
G
DAS
L
ADY
W
QQT
A
RAMP
DK
I
A
V
V
D
N
-
HG
AS
----
Y
T
Y
S
A
L
D
HAAS
C
L
AN
WM
L
A
K
GI
E
S
GD
R
I
A
FQ
LP
GW
C
EF
T
V
IY
LAC
L
KIGAV
S
VP
L
LPSWRE
A
E
L
V
W
V
L
NK
C
QA
K
M
F-
--
--
F
A
P
T
LFK
Q
TR
PVDLILPL
Q
N
QLP
QL
Q
Q
I
V
G
---
VD
K
LA
--
PA
TS
S
L
S
LSQI
IA
D
-------------------
N
T
P
--
L
TT
A
ITT
H
G
D
E
L
A
A
V
LFTSGT
E
G
L
PKGV
M
L
TH
N
N
I
L
ASERA
Y
C
A
R
L
NLT
WQ
------
DV
F
MMP
AP
L
GH
A
TG
FLHGVT
APF
LI
GA
R
S
VL
L
D
IF
----
TP
D
A
CLAL
L
E
Q
Q
R
C
T
CMLGA
T
PFV
Y
DL
LN
V
L
E
K
QP
AD
-
-----
-
LS
A
LRF
F
L
CGGT
TIPKK
V
A
R
E
-----
C
QQ
L
G
I
K
---
LL
SV
YG
S
TE
S
SPHA
V
V
N
L
--
D
D
P
L
-S
R
FMH
-
T
D
G
Y
A
A
A
GVE
IK
V
VDD
ARK
T
LP
P
G
C
EGE
--
-
EA
S
---
R
G
P
N
V
F
-------
MG
YF
DE
P
EL
TA
R
A
L
DEE
GWY
Y
SGD
LC
R
M
DE
A
GY
IK
ITGR
KK
D
I
I
V
RGGEN
I
S
SR
E
V
E
D
IL
LQ
HPKI
H
DA
C
VV
AM
PD
E
R
L
GE
RS
C
AYVVL
K
A
PHH
S
LS
L
EE
V
--
V
A
F
F
S
RK
R
V
AK
Y
K
Y
P
EH
I
VVI
E
K
LPRT
A
SGKI
QKFL
LRK
DI
fig|340184.6.peg.3064
Escherichia coli B7A (20-535/548)
LW
G
DAS
L
ADY
W
QQT
A
RAMP
DK
I
A
V
V
D
N
-
HG
AS
----
Y
T
Y
S
A
L
D
HAAS
C
L
AN
WM
L
A
K
GI
E
S
GD
R
I
A
FQ
LP
GW
C
EF
T
V
IY
LAC
L
KIGAV
S
VP
L
LPSWRE
A
E
L
V
W
V
L
NK
C
QA
K
M
F-
--
--
F
A
P
T
LFK
Q
TR
PVDLILPL
Q
N
QLP
QL
Q
Q
I
V
G
---
VD
K
LA
--
PA
TS
S
L
S
LSQI
IA
D
-------------------
N
T
P
--
L
TT
A
ITT
H
G
D
E
L
A
A
V
LFTSGT
E
G
L
PKGV
M
L
TH
N
N
I
L
ASERA
Y
C
A
R
L
NLT
WQ
------
DV
F
MMP
AP
L
GH
A
TG
FLHGVT
APF
LI
GA
R
S
VL
L
D
IF
----
TP
D
A
CLAL
L
E
Q
Q
R
C
T
CMLGA
T
PFV
Y
DL
LN
V
L
E
K
QP
AD
-
-----
-
LS
A
LRF
F
L
CGGT
TIPKK
V
A
R
E
-----
C
QQ
L
G
I
K
---
LL
SV
YG
S
TE
S
SPHA
V
V
N
L
--
D
D
P
L
-S
R
FMH
-
T
D
G
Y
A
A
A
GVE
IK
V
VDD
ARK
T
LP
P
G
C
EGE
--
-
EA
S
---
R
G
P
N
V
F
-------
MG
YF
DE
P
EL
TA
R
A
L
DEE
GWY
Y
SGD
LC
R
M
DE
A
GY
IK
ITGR
KK
D
I
I
V
RGGEN
I
S
SR
E
V
E
D
IL
LQ
HPKI
H
DA
C
VV
AM
PD
E
R
L
GE
RS
C
AYVVL
K
A
PHH
S
LS
L
EE
V
--
V
A
F
F
S
RK
R
V
AK
Y
K
Y
P
EH
I
VVI
E
K
LPRT
A
SGKI
QKFL
LRK
DI
fig|340186.3.peg.2182
Escherichia coli E110019 (38-553/566)
LW
G
DAS
L
ADY
W
QQT
A
RAMP
DK
I
A
V
V
D
N
-
HG
AS
----
Y
T
Y
S
A
L
D
HAAS
C
L
AN
WM
L
A
K
GI
E
S
GD
R
I
A
FQ
LP
GW
C
EF
T
V
IY
LAC
L
KIGAV
S
VP
L
LPSWRE
A
E
L
V
W
V
L
NK
C
QA
K
M
F-
--
--
F
A
P
T
LFK
Q
TR
PVDLILPL
Q
N
QLP
QL
Q
Q
I
V
G
---
VD
K
LA
--
PA
TS
S
L
S
LSQI
IA
D
-------------------
N
T
P
--
L
TT
A
ITT
H
G
D
E
L
A
A
V
LFTSGT
E
G
L
PKGV
M
L
TH
N
N
I
L
ASERA
Y
C
A
R
L
NLT
WQ
------
DV
F
MMP
AP
L
GH
A
TG
FLHGVT
APF
LI
GA
R
S
VL
L
D
IF
----
TP
D
A
CLAL
L
E
Q
Q
R
C
T
CMLGA
T
PFV
Y
DL
LN
V
L
E
K
QP
AD
-
-----
-
LS
A
LRF
F
L
CGGT
TIPKK
V
A
R
E
-----
C
QQ
L
G
I
K
---
LL
SV
YG
S
TE
S
SPHA
V
V
N
L
--
D
D
P
L
-S
R
FMH
-
T
D
G
Y
A
A
A
GVE
IK
V
VDD
ARK
T
LP
P
G
C
EGE
--
-
EA
S
---
R
G
P
N
V
F
-------
MG
YF
DE
P
EL
TA
R
A
L
DEE
GWY
Y
SGD
LC
R
M
DE
A
GY
IK
ITGR
KK
D
I
I
V
RGGEN
I
S
SR
E
V
E
D
IL
LQ
HPKI
H
DA
C
VV
AM
PD
E
R
L
GE
RS
C
AYVVL
K
A
PHH
S
LS
L
EE
V
--
V
A
F
F
S
RK
R
V
AK
Y
K
Y
P
EH
I
VVI
E
K
LPRT
A
SGKI
QKFL
LRK
DI
fig|340186.5.peg.2253
Escherichia coli E110019 (20-535/548)
LW
G
DAS
L
ADY
W
QQT
A
RAMP
DK
I
A
V
V
D
N
-
HG
AS
----
Y
T
Y
S
A
L
D
HAAS
C
L
AN
WM
L
A
K
GI
E
S
GD
R
I
A
FQ
LP
GW
C
EF
T
V
IY
LAC
L
KIGAV
S
VP
L
LPSWRE
A
E
L
V
W
V
L
NK
C
QA
K
M
F-
--
--
F
A
P
T
LFK
Q
TR
PVDLILPL
Q
N
QLP
QL
Q
Q
I
V
G
---
VD
K
LA
--
PA
TS
S
L
S
LSQI
IA
D
-------------------
N
T
P
--
L
TT
A
ITT
H
G
D
E
L
A
A
V
LFTSGT
E
G
L
PKGV
M
L
TH
N
N
I
L
ASERA
Y
C
A
R
L
NLT
WQ
------
DV
F
MMP
AP
L
GH
A
TG
FLHGVT
APF
LI
GA
R
S
VL
L
D
IF
----
TP
D
A
CLAL
L
E
Q
Q
R
C
T
CMLGA
T
PFV
Y
DL
LN
V
L
E
K
QP
AD
-
-----
-
LS
A
LRF
F
L
CGGT
TIPKK
V
A
R
E
-----
C
QQ
L
G
I
K
---
LL
SV
YG
S
TE
S
SPHA
V
V
N
L
--
D
D
P
L
-S
R
FMH
-
T
D
G
Y
A
A
A
GVE
IK
V
VDD
ARK
T
LP
P
G
C
EGE
--
-
EA
S
---
R
G
P
N
V
F
-------
MG
YF
DE
P
EL
TA
R
A
L
DEE
GWY
Y
SGD
LC
R
M
DE
A
GY
IK
ITGR
KK
D
I
I
V
RGGEN
I
S
SR
E
V
E
D
IL
LQ
HPKI
H
DA
C
VV
AM
PD
E
R
L
GE
RS
C
AYVVL
K
A
PHH
S
LS
L
EE
V
--
V
A
F
F
S
RK
R
V
AK
Y
K
Y
P
EH
I
VVI
E
K
LPRT
A
SGKI
QKFL
LRK
DI
fig|679204.3.peg.627
Escherichia coli MS 145-7 (20-535/548)
LW
G
DAS
L
ADY
W
QQT
A
RAMP
DK
I
A
V
V
D
N
-
HG
AS
----
Y
T
Y
S
A
L
D
HAAS
C
L
AN
WM
L
A
K
GI
E
S
GD
R
I
A
FQ
LP
GW
C
EF
T
V
IY
LAC
L
KIGAV
S
VP
L
LPSWRE
A
E
L
V
W
V
L
NK
C
QA
K
M
F-
--
--
F
A
P
T
LFK
Q
TR
PVDLILPL
Q
N
QLP
QL
Q
Q
I
V
G
---
VD
K
LA
--
PA
TS
S
L
S
LSQI
IA
D
-------------------
N
T
P
--
L
TT
A
ITT
H
G
D
E
L
A
A
V
LFTSGT
E
G
L
PKGV
M
L
TH
N
N
I
L
ASERA
Y
C
A
R
L
NLT
WQ
------
DV
F
MMP
AP
L
GH
A
TG
FLHGVT
APF
LI
GA
R
S
VL
L
D
IF
----
TP
D
A
CLAL
L
E
Q
Q
R
C
T
CMLGA
T
PFV
Y
DL
LN
V
L
E
K
QP
AD
-
-----
-
LS
A
LRF
F
L
CGGT
TIPKK
V
A
R
E
-----
C
QQ
L
G
I
K
---
LL
SV
YG
S
TE
S
SPHA
V
V
N
L
--
D
D
P
L
-S
R
FMH
-
T
D
G
Y
A
A
A
GVE
IK
V
VDD
ARK
T
LP
P
G
C
EGE
--
-
EA
S
---
R
G
P
N
V
F
-------
MG
YF
DE
P
EL
TA
R
A
L
DEE
GWY
Y
SGD
LC
R
M
DE
A
GY
IK
ITGR
KK
D
I
I
V
RGGEN
I
S
SR
E
V
E
D
IL
LQ
HPKI
H
DA
C
VV
AM
PD
E
R
L
GE
RS
C
AYVVL
K
A
PHH
S
LS
L
EE
V
--
V
A
F
F
S
RK
R
V
AK
Y
K
Y
P
EH
I
VVI
E
K
LPRT
A
SGKI
QKFL
LRK
DI
fig|573235.3.peg.2470
Escherichia coli O26:H11 str. 11368 (20-535/548)
LW
G
DAS
L
ADY
W
QQT
A
RAMP
DK
I
A
V
V
D
N
-
HG
AS
----
Y
T
Y
S
A
L
D
HAAS
C
L
AN
WM
L
A
K
GI
E
S
GD
R
I
A
FQ
LP
GW
C
EF
T
V
IY
LAC
L
KIGAV
S
VP
L
LPSWRE
A
E
L
V
W
V
L
NK
C
QA
K
M
F-
--
--
F
A
P
T
LFK
Q
TR
PVDLILPL
Q
N
QLP
QL
Q
Q
I
V
G
---
VD
K
LA
--
PA
TS
S
L
S
LSQI
IA
D
-------------------
N
T
P
--
L
TT
A
ITT
H
G
D
E
L
A
A
V
LFTSGT
E
G
L
PKGV
M
L
TH
N
N
I
L
ASERA
Y
C
A
R
L
NLT
WQ
------
DV
F
MMP
AP
L
GH
A
TG
FLHGVT
APF
LI
GA
R
S
VL
L
D
IF
----
TP
D
A
CLAL
L
E
Q
Q
R
C
T
CMLGA
T
PFV
Y
DL
LN
V
L
E
K
QP
AD
-
-----
-
LS
A
LRF
F
L
CGGT
TIPKK
V
A
R
E
-----
C
QQ
L
G
I
K
---
LL
SV
YG
S
TE
S
SPHA
V
V
N
L
--
D
D
P
L
-S
R
FMH
-
T
D
G
Y
A
A
A
GVE
IK
V
VDD
ARK
T
LP
P
G
C
EGE
--
-
EA
S
---
R
G
P
N
V
F
-------
MG
YF
DE
P
EL
TA
R
A
L
DEE
GWY
Y
SGD
LC
R
M
DE
A
GY
IK
ITGR
KK
D
I
I
V
RGGEN
I
S
SR
E
V
E
D
IL
LQ
HPKI
H
DA
C
VV
AM
PD
E
R
L
GE
RS
C
AYVVL
K
A
PHH
S
LS
L
EE
V
--
V
A
F
F
S
RK
R
V
AK
Y
K
Y
P
EH
I
VVI
E
K
LPRT
A
SGKI
QKFL
LRK
DI
fig|409438.11.peg.1971
Escherichia coli SE11 (20-535/548)
LW
G
DAS
L
ADY
W
QQT
A
RAMP
DK
I
A
V
V
D
N
-
HG
AS
----
Y
T
Y
S
A
L
D
HAAS
C
L
AN
WM
L
A
K
GI
E
S
GD
R
I
A
FQ
LP
GW
C
EF
T
V
IY
LAC
L
KIGAV
S
VP
L
LPSWRE
A
E
L
V
W
V
L
NK
C
QA
K
M
F-
--
--
F
A
P
T
LFK
Q
TR
PVDLILPL
Q
N
QLP
QL
Q
Q
I
V
G
---
VD
K
LA
--
PA
TS
S
L
S
LSQI
IA
D
-------------------
N
T
P
--
L
TT
A
ITT
H
G
D
E
L
A
A
V
LFTSGT
E
G
L
PKGV
M
L
TH
N
N
I
L
ASERA
Y
C
A
R
L
NLT
WQ
------
DV
F
MMP
AP
L
GH
A
TG
FLHGVT
APF
LI
GA
R
S
VL
L
D
IF
----
TP
D
A
CLAL
L
E
Q
Q
R
C
T
CMLGA
T
PFV
Y
DL
LN
V
L
E
K
QP
AD
-
-----
-
LS
A
LRF
F
L
CGGT
TIPKK
V
A
R
E
-----
C
QQ
L
G
I
K
---
LL
SV
YG
S
TE
S
SPHA
V
V
N
L
--
D
D
P
L
-S
R
FMH
-
T
D
G
Y
A
A
A
GVE
IK
V
VDD
ARK
T
LP
P
G
C
EGE
--
-
EA
S
---
R
G
P
N
V
F
-------
MG
YF
DE
P
EL
TA
R
A
L
DEE
GWY
Y
SGD
LC
R
M
DE
A
GY
IK
ITGR
KK
D
I
I
V
RGGEN
I
S
SR
E
V
E
D
IL
LQ
HPKI
H
DA
C
VV
AM
PD
E
R
L
GE
RS
C
AYVVL
K
A
PHH
S
LS
L
EE
V
--
V
A
F
F
S
RK
R
V
AK
Y
K
Y
P
EH
I
VVI
E
K
LPRT
A
SGKI
QKFL
LRK
DI
fig|656443.3.peg.2371
Escherichia coli TA271 (20-535/548)
LW
G
DAS
L
ADY
W
QQT
A
RAMP
DK
I
A
V
V
D
N
-
HG
AS
----
Y
T
Y
S
A
L
D
HAAS
C
L
AN
WM
L
A
K
GI
E
S
GD
R
I
A
FQ
LP
GW
C
EF
T
V
IY
LAC
L
KIGAV
S
VP
L
LPSWRE
A
E
L
V
W
V
L
NK
C
QA
K
M
F-
--
--
F
A
P
T
LFK
Q
TR
PVDLILPL
Q
N
QLP
QL
Q
Q
I
V
G
---
VD
K
LA
--
PA
TS
S
L
S
LSQI
IA
D
-------------------
N
T
P
--
L
TT
A
ITT
H
G
D
E
L
A
A
V
LFTSGT
E
G
L
PKGV
M
L
TH
N
N
I
L
ASERA
Y
C
A
R
L
NLT
WQ
------
DV
F
MMP
AP
L
GH
A
TG
FLHGVT
APF
LI
GA
R
S
VL
L
D
IF
----
TP
D
A
CLAL
L
E
Q
Q
R
C
T
CMLGA
T
PFV
Y
DL
LN
V
L
E
K
QP
AD
-
-----
-
LS
A
LRF
F
L
CGGT
TIPKK
V
A
R
E
-----
C
QQ
L
G
I
K
---
LL
SV
YG
S
TE
S
SPHA
V
V
N
L
--
D
D
P
L
-S
R
FMH
-
T
D
G
Y
A
A
A
GVE
IK
V
VDD
ARK
T
LP
P
G
C
EGE
--
-
EA
S
---
R
G
P
N
V
F
-------
MG
YF
DE
P
EL
TA
R
A
L
DEE
GWY
Y
SGD
LC
R
M
DE
A
GY
IK
ITGR
KK
D
I
I
V
RGGEN
I
S
SR
E
V
E
D
IL
LQ
HPKI
H
DA
C
VV
AM
PD
E
R
L
GE
RS
C
AYVVL
K
A
PHH
S
LS
L
EE
V
--
V
A
F
F
S
RK
R
V
AK
Y
K
Y
P
EH
I
VVI
E
K
LPRT
A
SGKI
QKFL
LRK
DI
fig|550677.3.peg.1193
Escherichia coli B354 (20-535/548)
LW
G
DAS
L
ADY
W
QQT
A
RAMP
DK
I
A
V
V
D
N
-
HG
AS
----
Y
T
Y
S
A
L
D
HAAS
C
L
AN
WM
L
A
K
GI
E
S
GD
R
I
A
FQ
LP
GW
C
EF
T
V
IY
LAC
L
KIGAV
S
VP
L
LPSWRE
A
E
L
V
W
V
L
NK
C
QA
K
M
F-
--
--
F
A
P
T
LFK
Q
TR
PVDLILPL
Q
N
QLP
QL
Q
Q
I
V
G
---
VD
K
LA
--
PA
TS
A
L
S
LSQI
IA
D
-------------------
N
T
P
--
L
TT
A
ITV
H
G
D
E
L
A
A
V
LFTSGT
E
G
L
PKGV
M
L
TH
N
N
I
L
ASERA
Y
C
A
R
L
NLT
WQ
------
DV
F
MMP
AP
L
GH
A
TG
FLHGVT
APF
LI
GA
R
S
VL
L
D
IF
----
TP
D
A
CLAL
L
E
Q
Q
R
C
T
CMLGA
T
PFV
Y
DL
LN
L
L
E
K
QP
AD
-
-----
-
LS
A
LRF
F
L
CGGT
TIPKK
V
A
R
E
-----
C
QQ
R
G
I
K
---
LL
SV
YG
S
TE
S
SPHA
V
V
N
L
--
D
D
P
L
-S
R
FMH
-
T
D
G
Y
A
A
A
GVE
IK
V
VDD
ARK
T
LP
P
G
Y
EGE
--
-
EA
S
---
R
G
P
N
V
F
-------
MG
YF
DE
P
EL
TA
R
A
L
DEE
GWY
Y
SGD
LC
R
M
DE
A
GY
IK
ITGR
KK
D
I
I
V
RGGEN
I
S
SR
E
V
E
D
IL
LQ
HPKI
H
DA
C
VV
AM
PD
E
R
L
GE
RS
C
AYVVL
K
A
PHH
S
LS
L
EE
V
--
V
A
F
F
S
RK
R
V
AK
Y
K
Y
P
EH
I
VVI
E
K
LPRT
A
SGKI
QKFL
LRK
DI
fig|656408.3.peg.1857
Escherichia coli H591 (20-535/548)
LW
G
DAS
L
ADY
W
QQT
A
RAMP
DK
I
A
V
V
D
N
-
HG
AS
----
Y
N
Y
S
A
L
D
HAAS
C
L
AN
WM
L
A
K
GI
E
S
GD
R
I
A
FQ
LP
GW
C
EF
T
V
IY
LAC
L
KIGAV
S
VP
L
LPSWRE
A
E
L
V
W
V
L
NK
C
QA
K
M
F-
--
--
F
A
P
T
LFK
Q
TR
PVDLILPL
Q
N
QLP
QL
Q
Q
I
V
G
---
VD
K
LA
--
PA
TS
S
L
S
LSQI
IA
D
-------------------
N
T
P
--
L
TT
A
ITT
H
G
D
E
L
A
A
V
LFTSGT
E
G
L
PKGV
M
L
TH
N
N
I
L
ASERA
Y
C
A
R
L
NLT
WQ
------
DV
F
MMP
AP
L
GH
A
TG
FLHGVT
APF
LI
GA
R
S
VL
L
D
IF
----
TP
D
A
CLAL
L
E
Q
Q
R
C
T
CMLGA
T
PFV
Y
DL
LN
V
L
E
K
QP
AD
-
-----
-
LS
A
LRF
F
L
CGGT
TIPKK
V
A
R
E
-----
C
QQ
L
G
I
K
---
LL
SV
YG
S
TE
S
SPHA
V
V
N
L
--
D
D
P
L
-S
R
FMH
-
T
D
G
Y
A
A
A
GVE
IK
V
VDD
ARK
T
LP
P
G
C
EGE
--
-
EA
S
---
R
G
P
N
V
F
-------
MG
YF
DE
P
EL
TA
R
A
L
DEE
GWY
Y
SGD
LC
R
M
DE
A
GY
IK
ITGR
KK
D
I
I
V
RGGEN
I
S
SR
E
V
E
D
IL
LQ
HPKI
H
DA
C
VV
AM
PD
E
R
L
GE
RS
C
AYVVL
K
A
PHH
S
LS
L
EE
V
--
V
A
F
F
S
RK
R
V
AK
Y
K
Y
P
EH
I
VVI
E
K
LPRT
A
SGKI
QKFL
LRK
DI
fig|679206.4.peg.1191
Escherichia coli MS 119-7 (20-535/548)
LW
G
DAS
L
ADY
W
QQT
A
RAMP
DK
I
A
V
V
D
N
-
HG
AS
----
Y
N
Y
S
A
L
D
HAAS
C
L
AN
WM
L
A
K
GI
E
S
GD
R
I
A
FQ
LP
GW
C
EF
T
V
IY
LAC
L
KIGAV
S
VP
L
LPSWRE
A
E
L
V
W
V
L
NK
C
QA
K
M
F-
--
--
F
A
P
T
LFK
Q
TR
PVDLILPL
Q
N
QLP
QL
Q
Q
I
V
G
---
VD
K
LA
--
PA
TS
S
L
S
LSQI
IA
D
-------------------
N
T
P
--
L
TT
A
ITT
H
G
D
E
L
A
A
V
LFTSGT
E
G
L
PKGV
M
L
TH
N
N
I
L
ASERA
Y
C
A
R
L
NLT
WQ
------
DV
F
MMP
AP
L
GH
A
TG
FLHGVT
APF
LI
GA
R
S
VL
L
D
IF
----
TP
D
A
CLAL
L
E
Q
Q
R
C
T
CMLGA
T
PFV
Y
DL
LN
V
L
E
K
QP
AD
-
-----
-
LS
A
LRF
F
L
CGGT
TIPKK
V
A
R
E
-----
C
QQ
L
G
I
K
---
LL
SV
YG
S
TE
S
SPHA
V
V
N
L
--
D
D
P
L
-S
R
FMH
-
T
D
G
Y
A
A
A
GVE
IK
V
VDD
ARK
T
LP
P
G
C
EGE
--
-
EA
S
---
R
G
P
N
V
F
-------
MG
YF
DE
P
EL
TA
R
A
L
DEE
GWY
Y
SGD
LC
R
M
DE
A
GY
IK
ITGR
KK
D
I
I
V
RGGEN
I
S
SR
E
V
E
D
IL
LQ
HPKI
H
DA
C
VV
AM
PD
E
R
L
GE
RS
C
AYVVL
K
A
PHH
S
LS
L
EE
V
--
V
A
F
F
S
RK
R
V
AK
Y
K
Y
P
EH
I
VVI
E
K
LPRT
A
SGKI
QKFL
LRK
DI
fig|656437.3.peg.1927
Escherichia coli TA143 (20-535/548)
LW
G
DAS
L
ADY
W
QQT
A
RAMP
DK
I
A
V
V
D
N
-
HG
AS
----
Y
T
Y
S
A
L
D
HAAS
C
L
AN
WM
L
A
K
GI
E
S
GD
R
I
A
FQ
LP
GW
C
EF
T
V
IY
LAC
L
KIGAV
S
VP
L
LPSWRE
A
E
L
V
W
V
L
NK
C
QA
K
M
F-
--
--
F
A
P
T
LFK
Q
TR
PVDLILPL
Q
N
QLP
QL
Q
Q
I
V
G
---
VD
K
LA
--
PA
TS
S
L
S
LSQI
IA
D
-------------------
N
T
P
--
L
TT
A
ITV
H
G
D
E
L
A
V
V
LFTSGT
E
G
L
PKGV
M
L
TH
N
N
I
L
ASERA
Y
C
A
R
L
NLT
WQ
------
DV
F
MMP
AP
L
GH
A
TG
FLHGVT
APF
LI
GA
R
S
VL
L
D
IF
----
TP
D
A
CLAL
L
E
Q
Q
R
C
T
CMLGA
T
PFV
Y
DL
LN
L
L
E
K
QP
AD
-
-----
-
LS
A
LRF
F
L
CGGT
TIPKK
V
A
R
E
-----
C
QQ
H
G
I
K
---
LL
SV
YG
S
TE
S
SPHA
V
V
N
L
--
D
D
P
L
-S
R
FMH
-
T
D
G
Y
A
A
A
GVE
IK
V
VDD
ARK
T
LP
P
G
Y
EGE
--
-
EA
S
---
R
G
P
N
V
F
-------
MG
YF
DE
P
EL
TA
R
A
L
DEE
GWY
Y
SGD
LC
R
M
DE
A
GY
IK
ITGR
KK
D
I
I
V
RGGEN
I
S
SR
E
V
E
D
IL
LQ
HPKI
H
DA
C
VV
AM
PD
E
R
L
GE
RS
C
AYVVL
K
A
PHH
S
LS
L
EE
V
--
V
A
F
F
S
RK
R
V
AK
Y
K
Y
P
EH
I
VVI
E
K
LPRT
A
SGKI
QKFL
LRK
DI
fig|566546.3.peg.942
Escherichia coli W (20-534/547)
LW
G
DAS
L
ADY
W
QQT
A
RAMP
DK
I
A
V
V
D
N
-
HG
AS
----
Y
N
Y
S
A
L
D
HAAS
C
L
AN
WM
L
A
K
GI
E
S
GD
R
I
A
FQ
LP
GW
C
EF
T
V
IY
LAC
L
KIGAV
S
VP
L
LPSWRE
A
E
L
V
W
V
L
NK
C
QA
K
M
F-
--
--
F
A
P
T
LFK
Q
TR
PVDLILPL
Q
N
QLP
QL
Q
Q
I
V
G
---
VD
K
LA
--
PA
TS
S
L
S
LSQI
IA
D
-------------------
N
T
P
--
L
TT
A
ITT
H
G
D
E
L
A
A
V
LFTSGT
E
G
L
PKGV
M
L
TH
N
N
I
L
ASERA
Y
C
A
R
L
NLT
WQ
------
DV
F
MMP
AP
L
GH
A
TG
FLHGVT
APF
LI
GA
R
S
VL
L
D
IF
----
TP
D
A
CLAL
L
E
Q
Q
R
C
T
CMLGA
T
PFV
Y
DL
LN
L
L
E
K
QP
AD
-
-----
-
LS
A
LRF
F
L
CGGT
TIPKK
V
A
R
E
-----
C
QQ
R
G
I
K
---
LL
SV
YG
S
TE
S
SPHA
V
V
N
L
--
D
D
P
L
-S
R
FMH
-
T
D
G
Y
A
A
A
GVE
IK
V
VDD
ARK
T
LP
P
G
C
EGE
--
-
EA
S
---
R
G
P
N
V
F
-------
MG
YF
DE
P
EL
TA
R
A
L
DEE
GWY
Y
SGD
LC
R
M
DE
A
GY
IK
ITGR
KK
D
I
I
V
RGGEN
I
S
SR
E
V
E
D
IL
LQ
HPKI
H
DA
C
VV
AM
PD
E
R
L
GE
RS
C
AYVVL
K
A
PHH
S
LS
L
EE
V
--
V
A
F
F
S
RK
R
V
-
K
Y
K
Y
P
EH
I
VVI
E
K
LPRT
A
SGKI
QKFL
LRK
DI
fig|566546.4.peg.1857
Escherichia coli W (20-534/547)
LW
G
DAS
L
ADY
W
QQT
A
RAMP
DK
I
A
V
V
D
N
-
HG
AS
----
Y
N
Y
S
A
L
D
HAAS
C
L
AN
WM
L
A
K
GI
E
S
GD
R
I
A
FQ
LP
GW
C
EF
T
V
IY
LAC
L
KIGAV
S
VP
L
LPSWRE
A
E
L
V
W
V
L
NK
C
QA
K
M
F-
--
--
F
A
P
T
LFK
Q
TR
PVDLILPL
Q
N
QLP
QL
Q
Q
I
V
G
---
VD
K
LA
--
PA
TS
S
L
S
LSQI
IA
D
-------------------
N
T
P
--
L
TT
A
ITT
H
G
D
E
L
A
A
V
LFTSGT
E
G
L
PKGV
M
L
TH
N
N
I
L
ASERA
Y
C
A
R
L
NLT
WQ
------
DV
F
MMP
AP
L
GH
A
TG
FLHGVT
APF
LI
GA
R
S
VL
L
D
IF
----
TP
D
A
CLAL
L
E
Q
Q
R
C
T
CMLGA
T
PFV
Y
DL
LN
L
L
E
K
QP
AD
-
-----
-
LS
A
LRF
F
L
CGGT
TIPKK
V
A
R
E
-----
C
QQ
R
G
I
K
---
LL
SV
YG
S
TE
S
SPHA
V
V
N
L
--
D
D
P
L
-S
R
FMH
-
T
D
G
Y
A
A
A
GVE
IK
V
VDD
ARK
T
LP
P
G
C
EGE
--
-
EA
S
---
R
G
P
N
V
F
-------
MG
YF
DE
P
EL
TA
R
A
L
DEE
GWY
Y
SGD
LC
R
M
DE
A
GY
IK
ITGR
KK
D
I
I
V
RGGEN
I
S
SR
E
V
E
D
IL
LQ
HPKI
H
DA
C
VV
AM
PD
E
R
L
GE
RS
C
AYVVL
K
A
PHH
S
LS
L
EE
V
--
V
A
F
F
S
RK
R
V
-
K
Y
K
Y
P
EH
I
VVI
E
K
LPRT
A
SGKI
QKFL
LRK
DI
fig|656444.3.peg.2605
Escherichia coli TA280 (22-535/548)
G
DAS
L
T
DY
W
QQT
A
RAMP
DK
I
A
V
V
D
N
-
HG
AS
----
Y
T
Y
S
A
L
D
HAAS
C
L
AN
WM
L
T
K
GI
E
S
GD
R
I
A
FQ
LP
GW
C
EF
T
V
IY
LAC
L
KIGAV
S
VP
L
LPSWRE
A
E
L
V
W
V
L
NK
C
QA
K
M
F-
--
--
F
A
P
T
LFK
Q
TR
PVDLILPL
Q
N
QLP
QL
Q
Q
I
V
G
---
VD
K
LA
--
PA
TS
S
L
S
LSQI
IA
D
-------------------
N
T
P
--
L
TT
A
ITV
H
G
D
E
L
A
A
V
LFTSGT
E
G
L
PKGV
M
L
TH
N
N
I
L
ASERA
Y
C
A
R
L
NLT
WQ
------
DV
F
MMP
AP
L
GH
A
TG
FLHGVT
APF
LI
GA
R
S
VL
L
D
IF
----
TP
D
A
CLAL
L
E
Q
Q
R
C
T
CMLGA
T
PFV
Y
DL
LN
L
L
E
K
QP
AD
-
-----
-
LS
A
LRF
F
L
CGGT
TIPKK
V
A
R
E
-----
C
QQ
R
G
I
K
---
LL
SV
YG
S
TE
S
SPHA
V
V
N
L
--
D
D
P
L
-S
R
FMH
-
T
D
G
Y
A
A
A
GVE
IK
V
VDD
ARK
T
LP
P
G
C
EGE
--
-
EA
S
---
R
G
P
N
V
F
-------
MG
YF
DE
P
EL
TA
R
A
L
DEE
GWY
Y
SGD
LC
R
M
DE
A
GY
IK
ITGR
KK
D
I
I
V
RGGEN
I
S
SR
E
V
E
D
IL
LQ
HPKI
H
DA
C
VV
AM
PD
E
R
L
S
E
RS
C
AYVVL
K
A
PHH
S
LS
L
E
D
V
--
V
T
F
F
S
RK
R
V
AK
Y
K
Y
P
EH
I
VVI
E
K
LPRT
A
SGKI
QKFL
LRK
DI
fig|331111.12.peg.2199
Escherichia coli E24377A (20-535/548)
LW
G
DAS
L
ADY
W
QQT
A
RAMP
DK
I
A
V
V
D
N
-
HG
AS
----
Y
T
Y
S
A
L
D
HAAS
C
L
AN
WM
L
A
K
GI
E
S
GD
R
I
A
FQ
LP
GW
C
EF
T
V
IY
LAC
L
KIGAV
S
VP
L
LPSWRE
A
E
L
V
W
V
L
NK
C
QA
K
M
F-
--
--
F
A
P
T
LFK
Q
TR
PVDLILPL
Q
N
QLP
QL
Q
Q
I
V
G
---
VD
K
LA
--
PA
TS
S
L
S
LSQI
IA
D
-------------------
N
T
P
--
L
TT
A
ITT
H
G
D
E
L
A
A
V
LFTSGT
E
G
L
PKGV
M
L
TH
N
N
I
L
ASERA
Y
C
A
R
L
NLT
WQ
------
DV
F
MMP
AP
L
GH
A
TG
FLHGVT
APF
LI
GA
R
S
VL
L
D
IF
----
TP
D
A
CLAL
L
E
Q
Q
R
C
T
CMLGA
T
PFV
Y
DL
LN
V
L
E
K
QP
AD
-
-----
-
LS
A
LRF
F
L
CGGT
TIPKK
V
A
R
E
-----
C
QQ
L
G
I
K
---
LL
SV
YG
S
TE
S
SPHA
E
V
N
L
--
D
D
P
L
-S
R
FMH
-
T
D
G
Y
A
A
A
GVE
IK
V
VDD
ARK
T
LP
P
G
C
EGE
--
-
EA
S
---
R
G
P
N
V
F
-------
MG
YF
DE
P
EL
TA
R
A
L
DEE
GWY
Y
SGD
LC
R
M
DE
A
GY
IK
ITGR
KK
D
I
I
V
RGGEN
I
S
SR
E
V
E
D
IL
LQ
HPKI
H
DA
C
VV
AM
PD
E
R
L
GE
RS
C
AYVVL
K
A
PHH
S
LS
L
EE
V
--
V
A
F
F
S
RK
R
V
AK
Y
K
Y
P
EH
I
VVI
E
K
LPRT
A
SGKI
QKFL
LRK
DI
fig|331111.3.peg.4343
Escherichia coli E24377A (38-553/566)
LW
G
DAS
L
ADY
W
QQT
A
RAMP
DK
I
A
V
V
D
N
-
HG
AS
----
Y
T
Y
S
A
L
D
HAAS
C
L
AN
WM
L
A
K
GI
E
S
GD
R
I
A
FQ
LP
GW
C
EF
T
V
IY
LAC
L
KIGAV
S
VP
L
LPSWRE
A
E
L
V
W
V
L
NK
C
QA
K
M
F-
--
--
F
A
P
T
LFK
Q
TR
PVDLILPL
Q
N
QLP
QL
Q
Q
I
V
G
---
VD
K
LA
--
PA
TS
S
L
S
LSQI
IA
D
-------------------
N
T
P
--
L
TT
A
ITT
H
G
D
E
L
A
A
V
LFTSGT
E
G
L
PKGV
M
L
TH
N
N
I
L
ASERA
Y
C
A
R
L
NLT
WQ
------
DV
F
MMP
AP
L
GH
A
TG
FLHGVT
APF
LI
GA
R
S
VL
L
D
IF
----
TP
D
A
CLAL
L
E
Q
Q
R
C
T
CMLGA
T
PFV
Y
DL
LN
V
L
E
K
QP
AD
-
-----
-
LS
A
LRF
F
L
CGGT
TIPKK
V
A
R
E
-----
C
QQ
L
G
I
K
---
LL
SV
YG
S
TE
S
SPHA
E
V
N
L
--
D
D
P
L
-S
R
FMH
-
T
D
G
Y
A
A
A
GVE
IK
V
VDD
ARK
T
LP
P
G
C
EGE
--
-
EA
S
---
R
G
P
N
V
F
-------
MG
YF
DE
P
EL
TA
R
A
L
DEE
GWY
Y
SGD
LC
R
M
DE
A
GY
IK
ITGR
KK
D
I
I
V
RGGEN
I
S
SR
E
V
E
D
IL
LQ
HPKI
H
DA
C
VV
AM
PD
E
R
L
GE
RS
C
AYVVL
K
A
PHH
S
LS
L
EE
V
--
V
A
F
F
S
RK
R
V
AK
Y
K
Y
P
EH
I
VVI
E
K
LPRT
A
SGKI
QKFL
LRK
DI
fig|670888.3.peg.204
Escherichia coli 1827-70 (20-535/548)
LW
G
DAS
L
ADY
W
QQT
A
RAMP
DK
I
A
V
V
D
N
-
HG
AS
----
Y
T
Y
S
A
L
D
HAAS
C
L
AN
WM
L
A
K
GI
E
S
GD
R
I
A
FQ
LP
GW
C
EF
T
V
IY
LAC
L
KIGAV
S
VP
L
LPSWRE
A
E
L
V
W
V
L
NK
C
QA
K
M
F-
--
--
F
A
P
T
LFK
Q
TR
PVDLILPL
Q
N
QLP
QL
Q
Q
I
V
G
---
VD
K
LA
--
PA
TS
S
L
S
LSQI
IA
D
-------------------
N
T
P
--
L
TT
A
ITT
H
G
D
E
L
A
A
V
LFTSGT
E
G
L
PKGV
M
L
TH
N
N
I
L
ASERA
Y
C
A
R
L
NLT
WQ
------
DV
F
MMP
AP
L
GH
A
TG
FLHGVT
APF
LI
GA
R
S
VL
L
D
IF
----
TP
D
A
CLAL
L
E
Q
Q
R
C
T
CMLGA
T
PFV
Y
DL
LN
V
L
E
K
QP
AD
-
-----
-
LS
A
LRF
F
L
CGGT
TIPKK
V
A
R
E
-----
C
QQ
R
G
I
K
---
LL
SV
YG
S
TE
S
SPHA
V
V
N
L
--
D
D
P
L
-S
R
FMH
-
T
D
G
Y
A
A
A
GVE
IK
V
VDD
ARK
T
LP
P
G
C
EGE
--
-
EA
S
---
R
G
P
N
V
F
-------
MG
YF
DE
P
EL
TA
R
A
L
DEE
GWY
Y
SGD
LC
R
M
DE
A
GY
IK
ITGR
KK
D
I
I
V
RGGEN
I
S
SR
E
V
E
D
IL
LQ
HPKI
H
DA
C
VV
AM
PD
E
R
L
GE
RS
C
AYVVL
K
A
PHH
S
LS
L
EE
V
--
V
A
F
F
S
RK
R
V
AK
Y
K
Y
P
EH
I
VVI
E
K
LPRT
A
SGKI
QKFL
LRK
DI
fig|749550.3.peg.3168
Escherichia coli MS 200-1 (20-535/548)
LW
G
DAS
L
ADY
W
QQT
A
RAMP
D
N
I
A
V
V
D
N
-
HG
A
T
----
Y
T
Y
S
A
L
D
HAAS
C
L
AN
WM
L
A
K
GI
E
S
GD
R
I
A
FQ
LP
GW
C
EF
T
V
IY
LAC
L
K
T
GAV
S
VP
L
LPSWRE
A
E
L
V
W
V
L
NK
C
QA
K
M
F-
--
--
F
A
P
T
LFK
Q
TR
PVDLILPL
Q
N
QLP
QL
Q
Q
I
V
G
---
VD
K
LA
--
PA
TS
S
L
S
LSQI
L
A
D
-------------------
N
T
P
--
L
TT
A
ITV
H
G
D
E
L
A
A
V
LFTSGT
E
G
L
PKGV
M
L
TH
N
N
I
L
ASERA
Y
C
A
R
L
NLT
WQ
------
DV
F
MMP
AP
L
GH
A
TG
FLHGVT
APF
LI
GA
R
S
VL
L
D
IF
----
TP
D
A
CLAL
L
E
Q
Q
R
C
T
CMLGA
T
PFV
Y
DL
LN
L
L
E
K
QP
AD
-
-----
-
LS
A
LRF
F
L
CGGT
TIPKK
V
A
R
E
-----
C
QQ
R
G
I
K
---
LL
SV
YG
S
TE
S
SPHA
V
V
N
L
--
D
D
P
L
-P
R
FMH
-
T
D
G
Y
A
A
A
GVE
IK
V
VDD
ARK
T
LP
P
G
C
EGE
--
-
EA
S
---
R
G
P
N
V
F
-------
MG
YF
DE
P
EL
TA
R
A
L
DEE
GWY
Y
SGD
LC
R
M
DE
A
GY
IK
ITGR
KK
D
I
I
V
RGGEN
I
S
SR
E
V
E
D
IL
LQ
HPKI
H
DA
C
VV
AM
PD
E
R
L
GE
RS
C
AYVVL
K
A
PHH
S
LS
L
EE
V
--
V
A
F
F
S
RK
R
V
AK
Y
K
Y
P
EH
I
VVI
E
K
LPRT
V
SGKI
QKFL
LRK
DI
fig|562.371.peg.4555
Escherichia coli 1044A (20-535/548)
LW
G
DAS
L
ADY
W
QQT
A
RAMP
DK
I
A
V
V
D
N
-
HG
AS
----
Y
T
Y
S
A
L
D
HAAS
C
L
AN
WM
L
A
K
GI
E
S
GD
R
I
A
FQ
LP
GW
C
EF
T
V
IY
LAC
L
KIGAV
S
VP
L
LPSWRE
A
E
L
V
W
V
L
NK
C
QA
K
M
F-
--
--
F
T
P
T
LFK
Q
TR
PVDLILPL
Q
N
QLP
QL
Q
Q
I
V
G
---
VD
K
LA
--
PA
TS
S
L
S
LSQI
IA
D
-------------------
N
T
P
--
L
TT
A
ITT
H
G
D
E
L
A
A
V
LFTSGT
E
G
L
PKGV
M
L
TH
N
N
I
L
ASERA
Y
C
A
R
L
NLT
WQ
------
DV
F
MMP
AP
L
GH
A
TG
FLHGVT
APF
LI
GA
R
S
VL
L
D
IF
----
TP
D
A
CLAL
L
E
Q
Q
R
C
S
CMLGA
T
PFV
Y
DL
LN
L
L
E
K
QP
AD
-
-----
-
LS
A
LRF
F
L
CGGT
TIPKK
V
A
R
E
-----
C
QQ
R
G
I
K
---
LL
SV
YG
S
TE
S
SPHA
V
V
N
L
--
D
D
P
L
-S
R
FMH
-
T
D
G
Y
A
A
A
GVE
IK
V
VDD
ARK
T
LP
P
G
C
EGE
--
-
EA
S
---
R
G
P
N
V
F
-------
MG
YF
DE
P
EL
TA
R
A
L
DEE
GWY
Y
SGD
LC
R
M
DE
A
GY
IK
ITGR
KK
D
I
I
V
RGGEN
I
S
SR
E
V
E
D
IL
LQ
HPKI
H
DA
C
VV
AM
PD
E
R
L
GE
RS
C
AYVVL
K
A
PHH
S
LS
L
EE
V
--
V
A
F
F
S
RK
R
V
AK
Y
K
Y
P
EH
I
VVI
E
K
LPRT
A
SGKI
QKFL
LRK
DI
fig|562.372.peg.4788
Escherichia coli 1212A (20-535/548)
LW
G
DAS
L
ADY
W
QQT
A
RAMP
DK
I
A
V
V
D
N
-
HG
AS
----
Y
T
Y
S
A
L
D
HAAS
C
L
AN
WM
L
A
K
GI
E
S
GD
R
I
A
FQ
LP
GW
C
EF
T
V
IY
LAC
L
KIGAV
S
VP
L
LPSWRE
A
E
L
V
W
V
L
NK
C
QA
K
M
F-
--
--
F
T
P
T
LFK
Q
TR
PVDLILPL
Q
N
QLP
QL
Q
Q
I
V
G
---
VD
K
LA
--
PA
TS
S
L
S
LSQI
IA
D
-------------------
N
T
P
--
L
TT
A
ITT
H
G
D
E
L
A
A
V
LFTSGT
E
G
L
PKGV
M
L
TH
N
N
I
L
ASERA
Y
C
A
R
L
NLT
WQ
------
DV
F
MMP
AP
L
GH
A
TG
FLHGVT
APF
LI
GA
R
S
VL
L
D
IF
----
TP
D
A
CLAL
L
E
Q
Q
R
C
S
CMLGA
T
PFV
Y
DL
LN
L
L
E
K
QP
AD
-
-----
-
LS
A
LRF
F
L
CGGT
TIPKK
V
A
R
E
-----
C
QQ
R
G
I
K
---
LL
SV
YG
S
TE
S
SPHA
V
V
N
L
--
D
D
P
L
-S
R
FMH
-
T
D
G
Y
A
A
A
GVE
IK
V
VDD
ARK
T
LP
P
G
C
EGE
--
-
EA
S
---
R
G
P
N
V
F
-------
MG
YF
DE
P
EL
TA
R
A
L
DEE
GWY
Y
SGD
LC
R
M
DE
A
GY
IK
ITGR
KK
D
I
I
V
RGGEN
I
S
SR
E
V
E
D
IL
LQ
HPKI
H
DA
C
VV
AM
PD
E
R
L
GE
RS
C
AYVVL
K
A
PHH
S
LS
L
EE
V
--
V
A
F
F
S
RK
R
V
AK
Y
K
Y
P
EH
I
VVI
E
K
LPRT
A
SGKI
QKFL
LRK
DI
fig|562.374.peg.4324
Escherichia coli 536A (20-535/548)
LW
G
DAS
L
ADY
W
QQT
A
RAMP
DK
I
A
V
V
D
N
-
HG
AS
----
Y
T
Y
S
A
L
D
HAAS
C
L
AN
WM
L
A
K
GI
E
S
GD
R
I
A
FQ
LP
GW
C
EF
T
V
IY
LAC
L
KIGAV
S
VP
L
LPSWRE
A
E
L
V
W
V
L
NK
C
QA
K
M
F-
--
--
F
T
P
T
LFK
Q
TR
PVDLILPL
Q
N
QLP
QL
Q
Q
I
V
G
---
VD
K
LA
--
PA
TS
S
L
S
LSQI
IA
D
-------------------
N
T
P
--
L
TT
A
ITT
H
G
D
E
L
A
A
V
LFTSGT
E
G
L
PKGV
M
L
TH
N
N
I
L
ASERA
Y
C
A
R
L
NLT
WQ
------
DV
F
MMP
AP
L
GH
A
TG
FLHGVT
APF
LI
GA
R
S
VL
L
D
IF
----
TP
D
A
CLAL
L
E
Q
Q
R
C
S
CMLGA
T
PFV
Y
DL
LN
L
L
E
K
QP
AD
-
-----
-
LS
A
LRF
F
L
CGGT
TIPKK
V
A
R
E
-----
C
QQ
R
G
I
K
---
LL
SV
YG
S
TE
S
SPHA
V
V
N
L
--
D
D
P
L
-S
R
FMH
-
T
D
G
Y
A
A
A
GVE
IK
V
VDD
ARK
T
LP
P
G
C
EGE
--
-
EA
S
---
R
G
P
N
V
F
-------
MG
YF
DE
P
EL
TA
R
A
L
DEE
GWY
Y
SGD
LC
R
M
DE
A
GY
IK
ITGR
KK
D
I
I
V
RGGEN
I
S
SR
E
V
E
D
IL
LQ
HPKI
H
DA
C
VV
AM
PD
E
R
L
GE
RS
C
AYVVL
K
A
PHH
S
LS
L
EE
V
--
V
A
F
F
S
RK
R
V
AK
Y
K
Y
P
EH
I
VVI
E
K
LPRT
A
SGKI
QKFL
LRK
DI
fig|83334.1.peg.2434
Escherichia coli O157:H7 (20-535/548)
LW
G
DAS
L
ADY
W
QQT
A
RAMP
DK
I
A
V
V
D
N
-
HG
AS
----
Y
T
Y
S
A
L
D
HAAS
C
L
AN
WM
L
A
K
GI
E
S
GD
R
I
A
FQ
LP
GW
C
EF
T
V
IY
LAC
L
KIGAV
S
VP
L
LPSWRE
A
E
L
V
W
V
L
NK
C
QA
K
M
F-
--
--
F
T
P
T
LFK
Q
TR
PVDLILPL
Q
N
QLP
QL
Q
Q
I
V
G
---
VD
K
LA
--
PA
TS
S
L
S
LSQI
IA
D
-------------------
N
T
P
--
L
TT
A
ITT
H
G
D
E
L
A
A
V
LFTSGT
E
G
L
PKGV
M
L
TH
N
N
I
L
ASERA
Y
C
A
R
L
NLT
WQ
------
DV
F
MMP
AP
L
GH
A
TG
FLHGVT
APF
LI
GA
R
S
VL
L
D
IF
----
TP
D
A
CLAL
L
E
Q
Q
R
C
S
CMLGA
T
PFV
Y
DL
LN
L
L
E
K
QP
AD
-
-----
-
LS
A
LRF
F
L
CGGT
TIPKK
V
A
R
E
-----
C
QQ
R
G
I
K
---
LL
SV
YG
S
TE
S
SPHA
V
V
N
L
--
D
D
P
L
-S
R
FMH
-
T
D
G
Y
A
A
A
GVE
IK
V
VDD
ARK
T
LP
P
G
C
EGE
--
-
EA
S
---
R
G
P
N
V
F
-------
MG
YF
DE
P
EL
TA
R
A
L
DEE
GWY
Y
SGD
LC
R
M
DE
A
GY
IK
ITGR
KK
D
I
I
V
RGGEN
I
S
SR
E
V
E
D
IL
LQ
HPKI
H
DA
C
VV
AM
PD
E
R
L
GE
RS
C
AYVVL
K
A
PHH
S
LS
L
EE
V
--
V
A
F
F
S
RK
R
V
AK
Y
K
Y
P
EH
I
VVI
E
K
LPRT
A
SGKI
QKFL
LRK
DI
fig|155864.8.peg.2291
Escherichia coli O157:H7 EDL933 (20-535/548)
LW
G
DAS
L
ADY
W
QQT
A
RAMP
DK
I
A
V
V
D
N
-
HG
AS
----
Y
T
Y
S
A
L
D
HAAS
C
L
AN
WM
L
A
K
GI
E
S
GD
R
I
A
FQ
LP
GW
C
EF
T
V
IY
LAC
L
KIGAV
S
VP
L
LPSWRE
A
E
L
V
W
V
L
NK
C
QA
K
M
F-
--
--
F
T
P
T
LFK
Q
TR
PVDLILPL
Q
N
QLP
QL
Q
Q
I
V
G
---
VD
K
LA
--
PA
TS
S
L
S
LSQI
IA
D
-------------------
N
T
P
--
L
TT
A
ITT
H
G
D
E
L
A
A
V
LFTSGT
E
G
L
PKGV
M
L
TH
N
N
I
L
ASERA
Y
C
A
R
L
NLT
WQ
------
DV
F
MMP
AP
L
GH
A
TG
FLHGVT
APF
LI
GA
R
S
VL
L
D
IF
----
TP
D
A
CLAL
L
E
Q
Q
R
C
S
CMLGA
T
PFV
Y
DL
LN
L
L
E
K
QP
AD
-
-----
-
LS
A
LRF
F
L
CGGT
TIPKK
V
A
R
E
-----
C
QQ
R
G
I
K
---
LL
SV
YG
S
TE
S
SPHA
V
V
N
L
--
D
D
P
L
-S
R
FMH
-
T
D
G
Y
A
A
A
GVE
IK
V
VDD
ARK
T
LP
P
G
C
EGE
--
-
EA
S
---
R
G
P
N
V
F
-------
MG
YF
DE
P
EL
TA
R
A
L
DEE
GWY
Y
SGD
LC
R
M
DE
A
GY
IK
ITGR
KK
D
I
I
V
RGGEN
I
S
SR
E
V
E
D
IL
LQ
HPKI
H
DA
C
VV
AM
PD
E
R
L
GE
RS
C
AYVVL
K
A
PHH
S
LS
L
EE
V
--
V
A
F
F
S
RK
R
V
AK
Y
K
Y
P
EH
I
VVI
E
K
LPRT
A
SGKI
QKFL
LRK
DI
fig|478006.5.peg.2690
Escherichia coli O157:H7 str. EC4501 (20-535/548)
LW
G
DAS
L
ADY
W
QQT
A
RAMP
DK
I
A
V
V
D
N
-
HG
AS
----
Y
T
Y
S
A
L
D
HAAS
C
L
AN
WM
L
A
K
GI
E
S
GD
R
I
A
FQ
LP
GW
C
EF
T
V
IY
LAC
L
KIGAV
S
VP
L
LPSWRE
A
E
L
V
W
V
L
NK
C
QA
K
M
F-
--
--
F
T
P
T
LFK
Q
TR
PVDLILPL
Q
N
QLP
QL
Q
Q
I
V
G
---
VD
K
LA
--
PA
TS
S
L
S
LSQI
IA
D
-------------------
N
T
P
--
L
TT
A
ITT
H
G
D
E
L
A
A
V
LFTSGT
E
G
L
PKGV
M
L
TH
N
N
I
L
ASERA
Y
C
A
R
L
NLT
WQ
------
DV
F
MMP
AP
L
GH
A
TG
FLHGVT
APF
LI
GA
R
S
VL
L
D
IF
----
TP
D
A
CLAL
L
E
Q
Q
R
C
S
CMLGA
T
PFV
Y
DL
LN
L
L
E
K
QP
AD
-
-----
-
LS
A
LRF
F
L
CGGT
TIPKK
V
A
R
E
-----
C
QQ
R
G
I
K
---
LL
SV
YG
S
TE
S
SPHA
V
V
N
L
--
D
D
P
L
-S
R
FMH
-
T
D
G
Y
A
A
A
GVE
IK
V
VDD
ARK
T
LP
P
G
C
EGE
--
-
EA
S
---
R
G
P
N
V
F
-------
MG
YF
DE
P
EL
TA
R
A
L
DEE
GWY
Y
SGD
LC
R
M
DE
A
GY
IK
ITGR
KK
D
I
I
V
RGGEN
I
S
SR
E
V
E
D
IL
LQ
HPKI
H
DA
C
VV
AM
PD
E
R
L
GE
RS
C
AYVVL
K
A
PHH
S
LS
L
EE
V
--
V
A
F
F
S
RK
R
V
AK
Y
K
Y
P
EH
I
VVI
E
K
LPRT
A
SGKI
QKFL
LRK
DI
fig|478008.5.peg.4877
Escherichia coli O157:H7 str. EC869 (20-535/548)
LW
G
DAS
L
ADY
W
QQT
A
RAMP
DK
I
A
V
V
D
N
-
HG
AS
----
Y
T
Y
S
A
L
D
HAAS
C
L
AN
WM
L
A
K
GI
E
S
GD
R
I
A
FQ
LP
GW
C
EF
T
V
IY
LAC
L
KIGAV
S
VP
L
LPSWRE
A
E
L
V
W
V
L
NK
C
QA
K
M
F-
--
--
F
T
P
T
LFK
Q
TR
PVDLILPL
Q
N
QLP
QL
Q
Q
I
V
G
---
VD
K
LA
--
PA
TS
S
L
S
LSQI
IA
D
-------------------
N
T
P
--
L
TT
A
ITT
H
G
D
E
L
A
A
V
LFTSGT
E
G
L
PKGV
M
L
TH
N
N
I
L
ASERA
Y
C
A
R
L
NLT
WQ
------
DV
F
MMP
AP
L
GH
A
TG
FLHGVT
APF
LI
GA
R
S
VL
L
D
IF
----
TP
D
A
CLAL
L
E
Q
Q
R
C
S
CMLGA
T
PFV
Y
DL
LN
L
L
E
K
QP
AD
-
-----
-
LS
A
LRF
F
L
CGGT
TIPKK
V
A
R
E
-----
C
QQ
R
G
I
K
---
LL
SV
YG
S
TE
S
SPHA
V
V
N
L
--
D
D
P
L
-S
R
FMH
-
T
D
G
Y
A
A
A
GVE
IK
V
VDD
ARK
T
LP
P
G
C
EGE
--
-
EA
S
---
R
G
P
N
V
F
-------
MG
YF
DE
P
EL
TA
R
A
L
DEE
GWY
Y
SGD
LC
R
M
DE
A
GY
IK
ITGR
KK
D
I
I
V
RGGEN
I
S
SR
E
V
E
D
IL
LQ
HPKI
H
DA
C
VV
AM
PD
E
R
L
GE
RS
C
AYVVL
K
A
PHH
S
LS
L
EE
V
--
V
A
F
F
S
RK
R
V
AK
Y
K
Y
P
EH
I
VVI
E
K
LPRT
A
SGKI
QKFL
LRK
DI
fig|637388.3.peg.4937
Escherichia coli O157:H7 str. FRIK2000 (20-535/548)
LW
G
DAS
L
ADY
W
QQT
A
RAMP
DK
I
A
V
V
D
N
-
HG
AS
----
Y
T
Y
S
A
L
D
HAAS
C
L
AN
WM
L
A
K
GI
E
S
GD
R
I
A
FQ
LP
GW
C
EF
T
V
IY
LAC
L
KIGAV
S
VP
L
LPSWRE
A
E
L
V
W
V
L
NK
C
QA
K
M
F-
--
--
F
T
P
T
LFK
Q
TR
PVDLILPL
Q
N
QLP
QL
Q
Q
I
V
G
---
VD
K
LA
--
PA
TS
S
L
S
LSQI
IA
D
-------------------
N
T
P
--
L
TT
A
ITT
H
G
D
E
L
A
A
V
LFTSGT
E
G
L
PKGV
M
L
TH
N
N
I
L
ASERA
Y
C
A
R
L
NLT
WQ
------
DV
F
MMP
AP
L
GH
A
TG
FLHGVT
APF
LI
GA
R
S
VL
L
D
IF
----
TP
D
A
CLAL
L
E
Q
Q
R
C
S
CMLGA
T
PFV
Y
DL
LN
L
L
E
K
QP
AD
-
-----
-
LS
A
LRF
F
L
CGGT
TIPKK
V
A
R
E
-----
C
QQ
R
G
I
K
---
LL
SV
YG
S
TE
S
SPHA
V
V
N
L
--
D
D
P
L
-S
R
FMH
-
T
D
G
Y
A
A
A
GVE
IK
V
VDD
ARK
T
LP
P
G
C
EGE
--
-
EA
S
---
R
G
P
N
V
F
-------
MG
YF
DE
P
EL
TA
R
A
L
DEE
GWY
Y
SGD
LC
R
M
DE
A
GY
IK
ITGR
KK
D
I
I
V
RGGEN
I
S
SR
E
V
E
D
IL
LQ
HPKI
H
DA
C
VV
AM
PD
E
R
L
GE
RS
C
AYVVL
K
A
PHH
S
LS
L
EE
V
--
V
A
F
F
S
RK
R
V
AK
Y
K
Y
P
EH
I
VVI
E
K
LPRT
A
SGKI
QKFL
LRK
DI
fig|570506.3.peg.4295
Escherichia coli O157:H7 str. FRIK966 (20-535/548)
LW
G
DAS
L
ADY
W
QQT
A
RAMP
DK
I
A
V
V
D
N
-
HG
AS
----
Y
T
Y
S
A
L
D
HAAS
C
L
AN
WM
L
A
K
GI
E
S
GD
R
I
A
FQ
LP
GW
C
EF
T
V
IY
LAC
L
KIGAV
S
VP
L
LPSWRE
A
E
L
V
W
V
L
NK
C
QA
K
M
F-
--
--
F
T
P
T
LFK
Q
TR
PVDLILPL
Q
N
QLP
QL
Q
Q
I
V
G
---
VD
K
LA
--
PA
TS
S
L
S
LSQI
IA
D
-------------------
N
T
P
--
L
TT
A
ITT
H
G
D
E
L
A
A
V
LFTSGT
E
G
L
PKGV
M
L
TH
N
N
I
L
ASERA
Y
C
A
R
L
NLT
WQ
------
DV
F
MMP
AP
L
GH
A
TG
FLHGVT
APF
LI
GA
R
S
VL
L
D
IF
----
TP
D
A
CLAL
L
E
Q
Q
R
C
S
CMLGA
T
PFV
Y
DL
LN
L
L
E
K
QP
AD
-
-----
-
LS
A
LRF
F
L
CGGT
TIPKK
V
A
R
E
-----
C
QQ
R
G
I
K
---
LL
SV
YG
S
TE
S
SPHA
V
V
N
L
--
D
D
P
L
-S
R
FMH
-
T
D
G
Y
A
A
A
GVE
IK
V
VDD
ARK
T
LP
P
G
C
EGE
--
-
EA
S
---
R
G
P
N
V
F
-------
MG
YF
DE
P
EL
TA
R
A
L
DEE
GWY
Y
SGD
LC
R
M
DE
A
GY
IK
ITGR
KK
D
I
I
V
RGGEN
I
S
SR
E
V
E
D
IL
LQ
HPKI
H
DA
C
VV
AM
PD
E
R
L
GE
RS
C
AYVVL
K
A
PHH
S
LS
L
EE
V
--
V
A
F
F
S
RK
R
V
AK
Y
K
Y
P
EH
I
VVI
E
K
LPRT
A
SGKI
QKFL
LRK
DI
fig|386585.9.peg.2522
Escherichia coli O157:H7 str. Sakai (20-535/548)
LW
G
DAS
L
ADY
W
QQT
A
RAMP
DK
I
A
V
V
D
N
-
HG
AS
----
Y
T
Y
S
A
L
D
HAAS
C
L
AN
WM
L
A
K
GI
E
S
GD
R
I
A
FQ
LP
GW
C
EF
T
V
IY
LAC
L
KIGAV
S
VP
L
LPSWRE
A
E
L
V
W
V
L
NK
C
QA
K
M
F-
--
--
F
T
P
T
LFK
Q
TR
PVDLILPL
Q
N
QLP
QL
Q
Q
I
V
G
---
VD
K
LA
--
PA
TS
S
L
S
LSQI
IA
D
-------------------
N
T
P
--
L
TT
A
ITT
H
G
D
E
L
A
A
V
LFTSGT
E
G
L
PKGV
M
L
TH
N
N
I
L
ASERA
Y
C
A
R
L
NLT
WQ
------
DV
F
MMP
AP
L
GH
A
TG
FLHGVT
APF
LI
GA
R
S
VL
L
D
IF
----
TP
D
A
CLAL
L
E
Q
Q
R
C
S
CMLGA
T
PFV
Y
DL
LN
L
L
E
K
QP
AD
-
-----
-
LS
A
LRF
F
L
CGGT
TIPKK
V
A
R
E
-----
C
QQ
R
G
I
K
---
LL
SV
YG
S
TE
S
SPHA
V
V
N
L
--
D
D
P
L
-S
R
FMH
-
T
D
G
Y
A
A
A
GVE
IK
V
VDD
ARK
T
LP
P
G
C
EGE
--
-
EA
S
---
R
G
P
N
V
F
-------
MG
YF
DE
P
EL
TA
R
A
L
DEE
GWY
Y
SGD
LC
R
M
DE
A
GY
IK
ITGR
KK
D
I
I
V
RGGEN
I
S
SR
E
V
E
D
IL
LQ
HPKI
H
DA
C
VV
AM
PD
E
R
L
GE
RS
C
AYVVL
K
A
PHH
S
LS
L
EE
V
--
V
A
F
F
S
RK
R
V
AK
Y
K
Y
P
EH
I
VVI
E
K
LPRT
A
SGKI
QKFL
LRK
DI
fig|502346.5.peg.4993
Escherichia coli O157:H7 str. TW14588 (20-535/548)
LW
G
DAS
L
ADY
W
QQT
A
RAMP
DK
I
A
V
V
D
N
-
HG
AS
----
Y
T
Y
S
A
L
D
HAAS
C
L
AN
WM
L
A
K
GI
E
S
GD
R
I
A
FQ
LP
GW
C
EF
T
V
IY
LAC
L
KIGAV
S
VP
L
LPSWRE
A
E
L
V
W
V
L
NK
C
QA
K
M
F-
--
--
F
T
P
T
LFK
Q
TR
PVDLILPL
Q
N
QLP
QL
Q
Q
I
V
G
---
VD
K
LA
--
PA
TS
S
L
S
LSQI
IA
D
-------------------
N
T
P
--
L
TT
A
ITT
H
G
D
E
L
A
A
V
LFTSGT
E
G
L
PKGV
M
L
TH
N
N
I
L
ASERA
Y
C
A
R
L
NLT
WQ
------
DV
F
MMP
AP
L
GH
A
TG
FLHGVT
APF
LI
GA
R
S
VL
L
D
IF
----
TP
D
A
CLAL
L
E
Q
Q
R
C
S
CMLGA
T
PFV
Y
DL
LN
L
L
E
K
QP
AD
-
-----
-
LS
A
LRF
F
L
CGGT
TIPKK
V
A
R
E
-----
C
QQ
R
G
I
K
---
LL
SV
YG
S
TE
S
SPHA
V
V
N
L
--
D
D
P
L
-S
R
FMH
-
T
D
G
Y
A
A
A
GVE
IK
V
VDD
ARK
T
LP
P
G
C
EGE
--
-
EA
S
---
R
G
P
N
V
F
-------
MG
YF
DE
P
EL
TA
R
A
L
DEE
GWY
Y
SGD
LC
R
M
DE
A
GY
IK
ITGR
KK
D
I
I
V
RGGEN
I
S
SR
E
V
E
D
IL
LQ
HPKI
H
DA
C
VV
AM
PD
E
R
L
GE
RS
C
AYVVL
K
A
PHH
S
LS
L
EE
V
--
V
A
F
F
S
RK
R
V
AK
Y
K
Y
P
EH
I
VVI
E
K
LPRT
A
SGKI
QKFL
LRK
DI
fig|701177.3.peg.2097
Escherichia coli O55:H7 str. CB9615 (20-535/548)
LW
G
DAS
L
ADY
W
QQT
A
RAMP
DK
I
A
V
V
D
N
-
HG
AS
----
Y
T
Y
S
A
L
D
HAAS
C
L
AN
WM
L
A
K
GI
E
S
GD
R
I
A
FQ
LP
GW
C
EF
T
V
IY
LAC
L
KIGAV
S
VP
L
LPSWRE
A
E
L
V
W
V
L
NK
C
QA
K
M
F-
--
--
F
T
P
T
LFK
Q
TR
PVDLILPL
Q
N
QLP
QL
Q
Q
I
V
G
---
VD
K
LA
--
PA
TS
S
L
S
LSQI
IA
D
-------------------
N
T
P
--
L
TT
A
ITT
H
G
D
E
L
A
A
V
LFTSGT
E
G
L
PKGV
M
L
TH
N
N
I
L
ASERA
Y
C
A
R
L
NLT
WQ
------
DV
F
MMP
AP
L
GH
A
TG
FLHGVT
APF
LI
GA
R
S
VL
L
D
IF
----
TP
D
A
CLAL
L
E
Q
Q
R
C
S
CMLGA
T
PFV
Y
DL
LN
L
L
E
K
QP
AD
-
-----
-
LS
A
LRF
F
L
CGGT
TIPKK
V
A
R
E
-----
C
QQ
R
G
I
K
---
LL
SV
YG
S
TE
S
SPHA
V
V
N
L
--
D
D
P
L
-S
R
FMH
-
T
D
G
Y
A
A
A
GVE
IK
V
VDD
ARK
T
LP
P
G
C
EGE
--
-
EA
S
---
R
G
P
N
V
F
-------
MG
YF
DE
P
EL
TA
R
A
L
DEE
GWY
Y
SGD
LC
R
M
DE
A
GY
IK
ITGR
KK
D
I
I
V
RGGEN
I
S
SR
E
V
E
D
IL
LQ
HPKI
H
DA
C
VV
AM
PD
E
R
L
GE
RS
C
AYVVL
K
A
PHH
S
LS
L
EE
V
--
V
A
F
F
S
RK
R
V
AK
Y
K
Y
P
EH
I
VVI
E
K
LPRT
A
SGKI
QKFL
LRK
DI
fig|155864.1.peg.2443
Escherichia coli O157:H7 EDL933 (38-553/566)
LW
G
DAS
L
ADY
W
QQT
A
RAMP
DK
I
A
V
V
D
N
-
HG
AS
----
Y
T
Y
S
A
L
D
HAAS
C
L
AN
WM
L
A
K
GI
E
S
GD
R
I
A
FQ
LP
GW
C
EF
T
V
IY
LAC
L
KIGAV
S
VP
L
LPSWRE
A
E
L
V
W
V
L
NK
C
QA
K
M
F-
--
--
F
T
P
T
LFK
Q
TR
PVDLILPL
Q
N
QLP
QL
Q
Q
I
V
G
---
VD
K
LA
--
PA
TS
S
L
S
LSQI
IA
D
-------------------
N
T
P
--
L
TT
A
ITT
H
G
D
E
L
A
A
V
LFTSGT
E
G
L
PKGV
M
L
TH
N
N
I
L
ASERA
Y
C
A
R
L
NLT
WQ
------
DV
F
MMP
AP
L
GH
A
TG
FLHGVT
APF
LI
GA
R
S
VL
L
D
IF
----
TP
D
A
CLAL
L
E
Q
Q
R
C
S
CMLGA
T
PFV
Y
DL
LN
L
L
E
K
QP
AD
-
-----
-
LS
A
LRF
F
L
CGGT
TIPKK
V
A
R
E
-----
C
QQ
R
G
I
K
---
LL
SV
YG
S
TE
S
SPHA
V
V
N
L
--
D
D
P
L
-S
R
FMH
-
T
D
G
Y
A
A
A
GVE
IK
V
VDD
ARK
T
LP
P
G
C
EGE
--
-
EA
S
---
R
G
P
N
V
F
-------
MG
YF
DE
P
EL
TA
R
A
L
DEE
GWY
Y
SGD
LC
R
M
DE
A
GY
IK
ITGR
KK
D
I
I
V
RGGEN
I
S
SR
E
V
E
D
IL
LQ
HPKI
H
DA
C
VV
AM
PD
E
R
L
GE
RS
C
AYVVL
K
A
PHH
S
LS
L
EE
V
--
V
A
F
F
S
RK
R
V
AK
Y
K
Y
P
EH
I
VVI
E
K
LPRT
A
SGKI
QKFL
LRK
DI
fig|550676.3.peg.2009
Escherichia coli B185 (20-535/546)
LW
G
DAS
L
ADY
W
QQT
A
RAMP
DK
I
A
V
V
D
N
-
HG
AS
----
Y
T
Y
S
A
L
D
HTAS
C
L
AN
WM
L
A
K
GI
E
S
GD
R
I
A
FQ
LP
GW
C
EF
T
V
IY
LAC
L
KIGAV
S
VP
L
LPSWRE
A
E
L
V
W
V
L
NK
C
QA
K
M
F-
--
--
F
A
P
T
LFK
Q
TR
PVDLILPL
Q
N
QLP
QL
Q
Q
I
V
G
---
VD
K
LA
--
PA
TS
S
L
S
LSQI
IA
D
-------------------
N
T
P
--
L
TT
A
ITT
H
G
D
E
L
A
A
V
LFTSGT
E
G
L
PKGV
M
L
TH
N
N
I
L
ASERA
Y
C
A
R
L
NLT
WQ
------
DV
F
MMP
AP
L
GH
A
TG
FLHGVT
APF
LI
GA
R
S
VL
L
D
IF
----
TP
D
A
CLAL
L
E
Q
Q
R
C
T
CMLGA
T
PFV
Y
DL
LN
L
L
E
K
QP
AD
-
-----
-
LS
A
LRF
F
L
CGGT
TIPKK
V
A
R
E
-----
C
QQ
R
G
I
K
---
LL
SV
YG
S
TE
S
SPHA
V
V
N
L
--
D
D
P
L
-S
R
FMH
-
T
D
G
Y
A
A
A
GVE
IK
V
VDD
ARK
T
LP
P
G
C
EGE
--
-
EA
S
---
R
G
P
N
V
F
-------
MG
YF
DE
P
EL
TA
R
A
L
DEE
GWY
Y
SGD
LC
R
M
DE
A
GY
IK
ITGR
KK
D
I
I
V
RGGEN
I
S
SR
E
V
E
D
IL
LQ
HPKI
H
DA
C
VV
AM
PD
E
R
L
GE
RS
C
AYVVL
K
A
PHH
S
LS
L
EE
V
--
V
A
F
F
S
RK
R
V
AK
Y
K
Y
P
EH
I
VVI
E
K
LPRT
A
SGKI
QKFL
LRK
DI
fig|685038.3.peg.1719
Escherichia coli O83:H1 str. NRG 857C (20-535/548)
LW
G
DAS
L
ADY
W
QQT
A
RAMP
DK
I
A
V
V
D
N
-
HG
A
T
----
Y
T
Y
S
A
L
D
HAAS
C
L
AN
WM
L
A
K
GI
E
S
GD
R
I
A
FQ
LP
GW
C
EF
T
V
IY
LAC
L
K
T
GAV
S
VP
L
LPSWRE
A
E
L
V
W
V
L
NK
C
QA
K
M
F-
--
--
F
A
A
T
LFK
Q
TR
PVDLILPL
Q
N
QLP
QL
Q
Q
I
V
G
---
VD
K
LA
--
PA
TS
S
L
S
LSQI
L
A
D
-------------------
N
T
P
--
L
TT
A
ITT
H
A
D
E
L
A
A
V
LFTSGT
E
G
L
PKGV
M
L
TH
N
N
I
L
ASERA
Y
C
A
R
L
NLT
WQ
------
DV
F
MMP
AP
L
GH
A
TG
FLHGVT
APF
LI
GA
R
S
VL
L
D
IF
----
TP
D
A
CLAL
L
E
Q
Q
R
C
T
CMLGA
T
PFV
Y
DL
LN
L
L
E
K
QP
AD
-
-----
-
LS
A
LRF
F
L
CGGT
TIPKK
V
A
R
E
-----
C
QQ
R
G
I
K
---
LL
SV
YG
S
TE
S
SPHA
V
V
N
L
--
D
D
P
L
-P
R
FMH
-
T
D
G
Y
A
A
A
GVE
IK
V
VDD
ARK
T
LP
P
G
C
EGE
--
-
EA
S
---
R
G
P
N
V
F
-------
MG
YF
DE
P
EL
TA
R
A
L
DEE
GWY
Y
SGD
LC
R
M
DE
A
GY
IK
ITGR
KK
D
I
I
V
RGGEN
I
S
SR
E
V
E
D
IL
LQ
HPKI
H
DA
C
VV
AM
PD
E
R
L
GE
RS
C
AYVVL
K
A
PHH
S
LS
L
EE
V
--
V
A
F
F
S
RK
R
V
AK
Y
K
Y
P
EH
I
VVI
E
K
LPRT
V
SGKI
QKFL
LRK
DI
fig|1040638.4.peg.3761
Escherichia coli O104:H4 str. LB226692 (20-535/548)
LW
G
DAS
L
ADY
W
QQT
A
RAMP
DK
I
A
V
V
D
N
-
HG
AS
----
Y
T
Y
S
A
L
D
HAAS
C
L
AN
WM
L
A
K
GI
E
S
GD
R
I
A
FQ
LP
GW
C
EF
T
V
IY
LAC
L
KIGAV
S
VP
L
LPSWRE
A
E
L
V
W
V
L
NK
C
QA
K
M
F-
--
--
F
A
P
T
LFK
Q
TR
PVDLILPL
Q
N
QLP
QL
Q
Q
I
V
G
---
VD
K
LA
--
PA
TS
S
L
S
LSQI
IA
D
-------------------
N
T
P
--
L
TT
A
ITT
H
G
D
E
L
A
A
V
LFTSGT
E
G
L
PKGV
M
L
TH
N
N
I
L
ASERA
Y
C
A
R
L
NLT
WQ
------
DV
F
MMP
AP
L
GH
A
TG
FLHGVT
APF
LI
GA
R
S
VL
L
D
IF
----
TP
D
A
CLAL
L
E
Q
Q
R
C
T
CMLGA
T
PFV
Y
DL
LN
L
L
E
K
QP
AD
-
-----
-
LS
A
LRF
F
L
CGGT
TIPKK
V
A
R
E
-----
C
QQ
R
G
I
K
---
LL
SV
YG
S
TE
S
SPHA
V
V
N
L
--
D
D
P
L
-S
R
FMH
-
T
D
G
Y
A
A
A
GVE
IK
V
VDD
ARK
T
LP
P
G
C
EGE
--
-
EA
S
---
R
G
P
N
V
F
-------
MG
YF
DE
P
EL
TA
R
A
L
DEE
GWY
Y
SGD
LC
R
M
DE
A
GY
IK
ITGR
KK
D
I
I
V
RGGEN
I
S
SR
E
V
E
D
IL
LQ
HPKI
H
DA
C
VV
AM
PD
E
R
L
GE
RS
C
AYVVL
K
A
PHH
S
LS
L
EE
V
--
V
A
F
F
S
RK
R
V
AK
Y
K
Y
P
EH
I
VVI
E
K
LPRT
A
SGKI
QKFL
LRK
DI
fig|6666666.5357.peg.2468
Escherichia coli TY-2482 (20-535/548)
LW
G
DAS
L
ADY
W
QQT
A
RAMP
DK
I
A
V
V
D
N
-
HG
AS
----
Y
T
Y
S
A
L
D
HAAS
C
L
AN
WM
L
A
K
GI
E
S
GD
R
I
A
FQ
LP
GW
C
EF
T
V
IY
LAC
L
KIGAV
S
VP
L
LPSWRE
A
E
L
V
W
V
L
NK
C
QA
K
M
F-
--
--
F
A
P
T
LFK
Q
TR
PVDLILPL
Q
N
QLP
QL
Q
Q
I
V
G
---
VD
K
LA
--
PA
TS
S
L
S
LSQI
IA
D
-------------------
N
T
P
--
L
TT
A
ITT
H
G
D
E
L
A
A
V
LFTSGT
E
G
L
PKGV
M
L
TH
N
N
I
L
ASERA
Y
C
A
R
L
NLT
WQ
------
DV
F
MMP
AP
L
GH
A
TG
FLHGVT
APF
LI
GA
R
S
VL
L
D
IF
----
TP
D
A
CLAL
L
E
Q
Q
R
C
T
CMLGA
T
PFV
Y
DL
LN
L
L
E
K
QP
AD
-
-----
-
LS
A
LRF
F
L
CGGT
TIPKK
V
A
R
E
-----
C
QQ
R
G
I
K
---
LL
SV
YG
S
TE
S
SPHA
V
V
N
L
--
D
D
P
L
-S
R
FMH
-
T
D
G
Y
A
A
A
GVE
IK
V
VDD
ARK
T
LP
P
G
C
EGE
--
-
EA
S
---
R
G
P
N
V
F
-------
MG
YF
DE
P
EL
TA
R
A
L
DEE
GWY
Y
SGD
LC
R
M
DE
A
GY
IK
ITGR
KK
D
I
I
V
RGGEN
I
S
SR
E
V
E
D
IL
LQ
HPKI
H
DA
C
VV
AM
PD
E
R
L
GE
RS
C
AYVVL
K
A
PHH
S
LS
L
EE
V
--
V
A
F
F
S
RK
R
V
AK
Y
K
Y
P
EH
I
VVI
E
K
LPRT
A
SGKI
QKFL
LRK
DI
fig|344610.3.peg.2443
Escherichia coli 53638 (20-535/548)
LW
G
DAS
L
ADY
W
QQT
A
RAMP
DK
I
A
V
V
D
N
-
HG
AS
----
Y
T
Y
S
A
L
D
HAAS
C
L
AN
WM
L
A
K
GI
E
S
GD
R
I
A
FQ
LP
GW
C
EF
T
V
IY
LAC
L
KIGAV
S
VP
L
LPSWRE
A
E
L
V
W
V
L
NK
C
QA
K
M
F-
--
--
F
A
P
T
LFK
Q
TR
PVDLILPL
Q
N
QLP
QL
Q
Q
I
V
G
---
VD
K
LA
--
PA
TS
S
L
S
LSQI
IA
D
-------------------
N
T
P
--
L
TT
A
ITT
H
G
D
E
L
A
A
V
LFTSGT
E
G
L
PKGV
M
L
TH
N
N
I
L
ASERA
Y
C
A
R
L
NLT
WQ
------
DV
F
MMP
AP
L
GH
A
TG
FLHGVT
APF
LI
GA
R
S
VL
L
D
IF
----
TP
D
A
CLAL
L
E
Q
Q
R
C
T
CMLGA
T
PFV
Y
DL
LN
L
L
E
K
QP
AD
-
-----
-
LS
A
LRF
F
L
CGGT
TIPKK
V
A
R
E
-----
C
QQ
R
G
I
K
---
LL
SV
YG
S
TE
S
SPHA
V
V
N
L
--
D
D
P
L
-S
R
FMH
-
T
D
G
Y
A
A
A
GVE
IK
V
VDD
ARK
T
LP
P
G
C
EGE
--
-
EA
S
---
R
G
P
N
V
F
-------
MG
YF
DE
P
EL
TA
R
A
L
DEE
GWY
Y
SGD
LC
R
M
DE
A
GY
IK
ITGR
KK
D
I
I
V
RGGEN
I
S
SR
E
V
E
D
IL
LQ
HPKI
H
DA
C
VV
AM
PD
E
R
L
GE
RS
C
AYVVL
K
A
PHH
S
LS
L
EE
V
--
V
A
F
F
S
RK
R
V
AK
Y
K
Y
P
EH
I
VVI
E
K
LPRT
A
SGKI
QKFL
LRK
DI
fig|344610.7.peg.5355
Escherichia coli 53638 (20-535/548)
LW
G
DAS
L
ADY
W
QQT
A
RAMP
DK
I
A
V
V
D
N
-
HG
AS
----
Y
T
Y
S
A
L
D
HAAS
C
L
AN
WM
L
A
K
GI
E
S
GD
R
I
A
FQ
LP
GW
C
EF
T
V
IY
LAC
L
KIGAV
S
VP
L
LPSWRE
A
E
L
V
W
V
L
NK
C
QA
K
M
F-
--
--
F
A
P
T
LFK
Q
TR
PVDLILPL
Q
N
QLP
QL
Q
Q
I
V
G
---
VD
K
LA
--
PA
TS
S
L
S
LSQI
IA
D
-------------------
N
T
P
--
L
TT
A
ITT
H
G
D
E
L
A
A
V
LFTSGT
E
G
L
PKGV
M
L
TH
N
N
I
L
ASERA
Y
C
A
R
L
NLT
WQ
------
DV
F
MMP
AP
L
GH
A
TG
FLHGVT
APF
LI
GA
R
S
VL
L
D
IF
----
TP
D
A
CLAL
L
E
Q
Q
R
C
T
CMLGA
T
PFV
Y
DL
LN
L
L
E
K
QP
AD
-
-----
-
LS
A
LRF
F
L
CGGT
TIPKK
V
A
R
E
-----
C
QQ
R
G
I
K
---
LL
SV
YG
S
TE
S
SPHA
V
V
N
L
--
D
D
P
L
-S
R
FMH
-
T
D
G
Y
A
A
A
GVE
IK
V
VDD
ARK
T
LP
P
G
C
EGE
--
-
EA
S
---
R
G
P
N
V
F
-------
MG
YF
DE
P
EL
TA
R
A
L
DEE
GWY
Y
SGD
LC
R
M
DE
A
GY
IK
ITGR
KK
D
I
I
V
RGGEN
I
S
SR
E
V
E
D
IL
LQ
HPKI
H
DA
C
VV
AM
PD
E
R
L
GE
RS
C
AYVVL
K
A
PHH
S
LS
L
EE
V
--
V
A
F
F
S
RK
R
V
AK
Y
K
Y
P
EH
I
VVI
E
K
LPRT
A
SGKI
QKFL
LRK
DI
fig|585055.6.peg.1898
Escherichia coli 55989 (20-535/548)
LW
G
DAS
L
ADY
W
QQT
A
RAMP
DK
I
A
V
V
D
N
-
HG
AS
----
Y
T
Y
S
A
L
D
HAAS
C
L
AN
WM
L
A
K
GI
E
S
GD
R
I
A
FQ
LP
GW
C
EF
T
V
IY
LAC
L
KIGAV
S
VP
L
LPSWRE
A
E
L
V
W
V
L
NK
C
QA
K
M
F-
--
--
F
A
P
T
LFK
Q
TR
PVDLILPL
Q
N
QLP
QL
Q
Q
I
V
G
---
VD
K
LA
--
PA
TS
S
L
S
LSQI
IA
D
-------------------
N
T
P
--
L
TT
A
ITT
H
G
D
E
L
A
A
V
LFTSGT
E
G
L
PKGV
M
L
TH
N
N
I
L
ASERA
Y
C
A
R
L
NLT
WQ
------
DV
F
MMP
AP
L
GH
A
TG
FLHGVT
APF
LI
GA
R
S
VL
L
D
IF
----
TP
D
A
CLAL
L
E
Q
Q
R
C
T
CMLGA
T
PFV
Y
DL
LN
L
L
E
K
QP
AD
-
-----
-
LS
A
LRF
F
L
CGGT
TIPKK
V
A
R
E
-----
C
QQ
R
G
I
K
---
LL
SV
YG
S
TE
S
SPHA
V
V
N
L
--
D
D
P
L
-S
R
FMH
-
T
D
G
Y
A
A
A
GVE
IK
V
VDD
ARK
T
LP
P
G
C
EGE
--
-
EA
S
---
R
G
P
N
V
F
-------
MG
YF
DE
P
EL
TA
R
A
L
DEE
GWY
Y
SGD
LC
R
M
DE
A
GY
IK
ITGR
KK
D
I
I
V
RGGEN
I
S
SR
E
V
E
D
IL
LQ
HPKI
H
DA
C
VV
AM
PD
E
R
L
GE
RS
C
AYVVL
K
A
PHH
S
LS
L
EE
V
--
V
A
F
F
S
RK
R
V
AK
Y
K
Y
P
EH
I
VVI
E
K
LPRT
A
SGKI
QKFL
LRK
DI
fig|585055.8.peg.1901
Escherichia coli 55989 (20-535/548)
LW
G
DAS
L
ADY
W
QQT
A
RAMP
DK
I
A
V
V
D
N
-
HG
AS
----
Y
T
Y
S
A
L
D
HAAS
C
L
AN
WM
L
A
K
GI
E
S
GD
R
I
A
FQ
LP
GW
C
EF
T
V
IY
LAC
L
KIGAV
S
VP
L
LPSWRE
A
E
L
V
W
V
L
NK
C
QA
K
M
F-
--
--
F
A
P
T
LFK
Q
TR
PVDLILPL
Q
N
QLP
QL
Q
Q
I
V
G
---
VD
K
LA
--
PA
TS
S
L
S
LSQI
IA
D
-------------------
N
T
P
--
L
TT
A
ITT
H
G
D
E
L
A
A
V
LFTSGT
E
G
L
PKGV
M
L
TH
N
N
I
L
ASERA
Y
C
A
R
L
NLT
WQ
------
DV
F
MMP
AP
L
GH
A
TG
FLHGVT
APF
LI
GA
R
S
VL
L
D
IF
----
TP
D
A
CLAL
L
E
Q
Q
R
C
T
CMLGA
T
PFV
Y
DL
LN
L
L
E
K
QP
AD
-
-----
-
LS
A
LRF
F
L
CGGT
TIPKK
V
A
R
E
-----
C
QQ
R
G
I
K
---
LL
SV
YG
S
TE
S
SPHA
V
V
N
L
--
D
D
P
L
-S
R
FMH
-
T
D
G
Y
A
A
A
GVE
IK
V
VDD
ARK
T
LP
P
G
C
EGE
--
-
EA
S
---
R
G
P
N
V
F
-------
MG
YF
DE
P
EL
TA
R
A
L
DEE
GWY
Y
SGD
LC
R
M
DE
A
GY
IK
ITGR
KK
D
I
I
V
RGGEN
I
S
SR
E
V
E
D
IL
LQ
HPKI
H
DA
C
VV
AM
PD
E
R
L
GE
RS
C
AYVVL
K
A
PHH
S
LS
L
EE
V
--
V
A
F
F
S
RK
R
V
AK
Y
K
Y
P
EH
I
VVI
E
K
LPRT
A
SGKI
QKFL
LRK
DI
fig|481805.3.peg.2082
Escherichia coli ATCC 8739 (20-535/548)
LW
G
DAS
L
ADY
W
QQT
A
RAMP
DK
I
A
V
V
D
N
-
HG
AS
----
Y
T
Y
S
A
L
D
HAAS
C
L
AN
WM
L
A
K
GI
E
S
GD
R
I
A
FQ
LP
GW
C
EF
T
V
IY
LAC
L
KIGAV
S
VP
L
LPSWRE
A
E
L
V
W
V
L
NK
C
QA
K
M
F-
--
--
F
A
P
T
LFK
Q
TR
PVDLILPL
Q
N
QLP
QL
Q
Q
I
V
G
---
VD
K
LA
--
PA
TS
S
L
S
LSQI
IA
D
-------------------
N
T
P
--
L
TT
A
ITT
H
G
D
E
L
A
A
V
LFTSGT
E
G
L
PKGV
M
L
TH
N
N
I
L
ASERA
Y
C
A
R
L
NLT
WQ
------
DV
F
MMP
AP
L
GH
A
TG
FLHGVT
APF
LI
GA
R
S
VL
L
D
IF
----
TP
D
A
CLAL
L
E
Q
Q
R
C
T
CMLGA
T
PFV
Y
DL
LN
L
L
E
K
QP
AD
-
-----
-
LS
A
LRF
F
L
CGGT
TIPKK
V
A
R
E
-----
C
QQ
R
G
I
K
---
LL
SV
YG
S
TE
S
SPHA
V
V
N
L
--
D
D
P
L
-S
R
FMH
-
T
D
G
Y
A
A
A
GVE
IK
V
VDD
ARK
T
LP
P
G
C
EGE
--
-
EA
S
---
R
G
P
N
V
F
-------
MG
YF
DE
P
EL
TA
R
A
L
DEE
GWY
Y
SGD
LC
R
M
DE
A
GY
IK
ITGR
KK
D
I
I
V
RGGEN
I
S
SR
E
V
E
D
IL
LQ
HPKI
H
DA
C
VV
AM
PD
E
R
L
GE
RS
C
AYVVL
K
A
PHH
S
LS
L
EE
V
--
V
A
F
F
S
RK
R
V
AK
Y
K
Y
P
EH
I
VVI
E
K
LPRT
A
SGKI
QKFL
LRK
DI
fig|481805.6.peg.2077
Escherichia coli ATCC 8739 (20-535/548)
LW
G
DAS
L
ADY
W
QQT
A
RAMP
DK
I
A
V
V
D
N
-
HG
AS
----
Y
T
Y
S
A
L
D
HAAS
C
L
AN
WM
L
A
K
GI
E
S
GD
R
I
A
FQ
LP
GW
C
EF
T
V
IY
LAC
L
KIGAV
S
VP
L
LPSWRE
A
E
L
V
W
V
L
NK
C
QA
K
M
F-
--
--
F
A
P
T
LFK
Q
TR
PVDLILPL
Q
N
QLP
QL
Q
Q
I
V
G
---
VD
K
LA
--
PA
TS
S
L
S
LSQI
IA
D
-------------------
N
T
P
--
L
TT
A
ITT
H
G
D
E
L
A
A
V
LFTSGT
E
G
L
PKGV
M
L
TH
N
N
I
L
ASERA
Y
C
A
R
L
NLT
WQ
------
DV
F
MMP
AP
L
GH
A
TG
FLHGVT
APF
LI
GA
R
S
VL
L
D
IF
----
TP
D
A
CLAL
L
E
Q
Q
R
C
T
CMLGA
T
PFV
Y
DL
LN
L
L
E
K
QP
AD
-
-----
-
LS
A
LRF
F
L
CGGT
TIPKK
V
A
R
E
-----
C
QQ
R
G
I
K
---
LL
SV
YG
S
TE
S
SPHA
V
V
N
L
--
D
D
P
L
-S
R
FMH
-
T
D
G
Y
A
A
A
GVE
IK
V
VDD
ARK
T
LP
P
G
C
EGE
--
-
EA
S
---
R
G
P
N
V
F
-------
MG
YF
DE
P
EL
TA
R
A
L
DEE
GWY
Y
SGD
LC
R
M
DE
A
GY
IK
ITGR
KK
D
I
I
V
RGGEN
I
S
SR
E
V
E
D
IL
LQ
HPKI
H
DA
C
VV
AM
PD
E
R
L
GE
RS
C
AYVVL
K
A
PHH
S
LS
L
EE
V
--
V
A
F
F
S
RK
R
V
AK
Y
K
Y
P
EH
I
VVI
E
K
LPRT
A
SGKI
QKFL
LRK
DI
fig|749537.3.peg.1779
Escherichia coli MS 115-1 (20-535/548)
LW
G
DAS
L
ADY
W
QQT
A
RAMP
DK
I
A
V
V
D
N
-
HG
AS
----
Y
T
Y
S
A
L
D
HAAS
C
L
AN
WM
L
A
K
GI
E
S
GD
R
I
A
FQ
LP
GW
C
EF
T
V
IY
LAC
L
KIGAV
S
VP
L
LPSWRE
A
E
L
V
W
V
L
NK
C
QA
K
M
F-
--
--
F
A
P
T
LFK
Q
TR
PVDLILPL
Q
N
QLP
QL
Q
Q
I
V
G
---
VD
K
LA
--
PA
TS
S
L
S
LSQI
IA
D
-------------------
N
T
P
--
L
TT
A
ITT
H
G
D
E
L
A
A
V
LFTSGT
E
G
L
PKGV
M
L
TH
N
N
I
L
ASERA
Y
C
A
R
L
NLT
WQ
------
DV
F
MMP
AP
L
GH
A
TG
FLHGVT
APF
LI
GA
R
S
VL
L
D
IF
----
TP
D
A
CLAL
L
E
Q
Q
R
C
T
CMLGA
T
PFV
Y
DL
LN
L
L
E
K
QP
AD
-
-----
-
LS
A
LRF
F
L
CGGT
TIPKK
V
A
R
E
-----
C
QQ
R
G
I
K
---
LL
SV
YG
S
TE
S
SPHA
V
V
N
L
--
D
D
P
L
-S
R
FMH
-
T
D
G
Y
A
A
A
GVE
IK
V
VDD
ARK
T
LP
P
G
C
EGE
--
-
EA
S
---
R
G
P
N
V
F
-------
MG
YF
DE
P
EL
TA
R
A
L
DEE
GWY
Y
SGD
LC
R
M
DE
A
GY
IK
ITGR
KK
D
I
I
V
RGGEN
I
S
SR
E
V
E
D
IL
LQ
HPKI
H
DA
C
VV
AM
PD
E
R
L
GE
RS
C
AYVVL
K
A
PHH
S
LS
L
EE
V
--
V
A
F
F
S
RK
R
V
AK
Y
K
Y
P
EH
I
VVI
E
K
LPRT
A
SGKI
QKFL
LRK
DI
fig|550672.3.peg.2545
Escherichia coli B088 (38-553/566)
LW
G
DAS
L
ADY
W
QQT
A
RAMP
DK
I
A
V
V
D
N
-
HG
AS
----
Y
T
Y
S
A
L
D
HAAS
C
L
AN
WM
L
A
K
GI
E
S
GD
R
I
A
FQ
LP
GW
C
EF
T
V
IY
LAC
L
KIGAV
S
VP
L
LPSWRE
A
E
L
V
W
V
L
NK
C
QA
K
M
F-
--
--
F
A
P
T
LFK
Q
TR
PVDLILPL
Q
N
QLP
QL
Q
Q
I
V
G
---
VD
K
LA
--
PA
TS
S
L
S
LSQI
IA
D
-------------------
N
T
P
--
L
TT
A
ITT
H
G
D
E
L
A
A
V
LFTSGT
E
G
L
PKGV
M
L
TH
N
N
I
L
ASERA
Y
C
A
R
L
NLT
WQ
------
DV
F
MMP
AP
L
GH
A
TG
FLHGVT
APF
LI
GA
R
S
VL
L
D
IF
----
TP
D
A
CLAL
L
E
Q
Q
R
C
T
CMLGA
T
PFV
Y
DL
LN
L
L
E
K
QP
AD
-
-----
-
LS
A
LRF
F
L
CGGT
TIPKK
V
A
R
E
-----
C
QQ
R
G
I
K
---
LL
SV
YG
S
TE
S
SPHA
V
V
N
L
--
D
D
P
L
-S
R
FMH
-
T
D
G
Y
A
A
A
GVE
IK
V
VDD
ARK
T
LP
P
G
C
EGE
--
-
EA
S
---
R
G
P
N
V
F
-------
MG
YF
DE
P
EL
TA
R
A
L
DEE
GWY
Y
SGD
LC
R
M
DE
A
GY
IK
ITGR
KK
D
I
I
V
RGGEN
I
S
SR
E
V
E
D
IL
LQ
HPKI
H
DA
C
VV
AM
PD
E
R
L
GE
RS
C
AYVVL
K
A
PHH
S
LS
L
EE
V
--
V
A
F
F
S
RK
R
V
AK
Y
K
Y
P
EH
I
VVI
E
K
LPRT
A
SGKI
QKFL
LRK
DI
fig|362663.8.peg.1663
Escherichia coli 536 (20-535/548)
LW
G
DAS
L
ADY
W
QQT
A
RAMP
DK
I
A
V
V
D
N
-
HG
A
T
----
Y
T
Y
S
A
L
D
HAAS
C
L
AN
WM
L
A
K
GI
E
S
GD
R
I
A
FQ
LP
GW
C
EF
T
V
IY
LAC
L
K
T
GAV
S
VP
L
LPSWRE
A
E
L
V
W
V
L
NK
C
QA
K
M
F-
--
--
F
A
P
T
LFK
Q
TR
PVDLILPL
Q
N
QLP
QL
Q
Q
I
V
G
---
VD
K
LA
--
PA
TS
S
L
S
LSQI
L
A
D
-------------------
N
T
P
--
L
TT
A
ITV
H
G
D
E
L
A
A
V
LFTSGT
E
G
L
PKGV
M
L
TH
N
N
I
L
ASERA
Y
C
A
R
L
NLT
WQ
------
DV
F
MMP
AP
L
GH
A
TG
FLHGVT
APF
LI
GA
R
S
VL
L
D
IF
----
TP
D
A
CLAL
L
E
Q
Q
R
C
T
CMLGA
T
PFV
Y
DL
LN
L
L
E
K
QP
AD
-
-----
-
LS
A
LRF
F
L
CGGT
TIPKK
V
A
R
E
-----
C
QQ
R
G
I
K
---
LL
SV
YG
S
TE
S
SPHA
V
V
N
L
--
D
D
P
L
-P
R
FMH
-
T
D
G
Y
A
A
A
GVE
IK
V
VDD
ARK
T
LP
P
G
C
EGE
--
-
EA
S
---
R
G
P
N
V
F
-------
MG
YF
DE
P
EL
TA
R
A
L
DEE
GWY
Y
SGD
LC
R
M
DE
A
GY
IK
ITGR
KK
D
I
I
V
RGGEN
I
S
SR
E
V
E
D
IL
LQ
HPKI
H
DA
C
VV
AM
PD
E
R
L
GE
RS
C
AYVVL
K
A
PHH
S
LS
L
EE
V
--
V
A
F
F
S
RK
R
V
AK
Y
K
Y
P
EH
I
VVI
E
K
LPRT
V
SGKI
QKFL
LRK
DI
fig|362663.9.peg.1667
Escherichia coli 536 (20-535/548)
LW
G
DAS
L
ADY
W
QQT
A
RAMP
DK
I
A
V
V
D
N
-
HG
A
T
----
Y
T
Y
S
A
L
D
HAAS
C
L
AN
WM
L
A
K
GI
E
S
GD
R
I
A
FQ
LP
GW
C
EF
T
V
IY
LAC
L
K
T
GAV
S
VP
L
LPSWRE
A
E
L
V
W
V
L
NK
C
QA
K
M
F-
--
--
F
A
P
T
LFK
Q
TR
PVDLILPL
Q
N
QLP
QL
Q
Q
I
V
G
---
VD
K
LA
--
PA
TS
S
L
S
LSQI
L
A
D
-------------------
N
T
P
--
L
TT
A
ITV
H
G
D
E
L
A
A
V
LFTSGT
E
G
L
PKGV
M
L
TH
N
N
I
L
ASERA
Y
C
A
R
L
NLT
WQ
------
DV
F
MMP
AP
L
GH
A
TG
FLHGVT
APF
LI
GA
R
S
VL
L
D
IF
----
TP
D
A
CLAL
L
E
Q
Q
R
C
T
CMLGA
T
PFV
Y
DL
LN
L
L
E
K
QP
AD
-
-----
-
LS
A
LRF
F
L
CGGT
TIPKK
V
A
R
E
-----
C
QQ
R
G
I
K
---
LL
SV
YG
S
TE
S
SPHA
V
V
N
L
--
D
D
P
L
-P
R
FMH
-
T
D
G
Y
A
A
A
GVE
IK
V
VDD
ARK
T
LP
P
G
C
EGE
--
-
EA
S
---
R
G
P
N
V
F
-------
MG
YF
DE
P
EL
TA
R
A
L
DEE
GWY
Y
SGD
LC
R
M
DE
A
GY
IK
ITGR
KK
D
I
I
V
RGGEN
I
S
SR
E
V
E
D
IL
LQ
HPKI
H
DA
C
VV
AM
PD
E
R
L
GE
RS
C
AYVVL
K
A
PHH
S
LS
L
EE
V
--
V
A
F
F
S
RK
R
V
AK
Y
K
Y
P
EH
I
VVI
E
K
LPRT
V
SGKI
QKFL
LRK
DI
fig|340197.5.peg.1941
Escherichia coli F11 (20-535/548)
LW
G
DAS
L
ADY
W
QQT
A
RAMP
DK
I
A
V
V
D
N
-
HG
A
T
----
Y
T
Y
S
A
L
D
HAAS
C
L
AN
WM
L
A
K
GI
E
S
GD
R
I
A
FQ
LP
GW
C
EF
T
V
IY
LAC
L
K
T
GAV
S
VP
L
LPSWRE
A
E
L
V
W
V
L
NK
C
QA
K
M
F-
--
--
F
A
P
T
LFK
Q
TR
PVDLILPL
Q
N
QLP
QL
Q
Q
I
V
G
---
VD
K
LA
--
PA
TS
S
L
S
LSQI
L
A
D
-------------------
N
T
P
--
L
TT
A
ITV
H
G
D
E
L
A
A
V
LFTSGT
E
G
L
PKGV
M
L
TH
N
N
I
L
ASERA
Y
C
A
R
L
NLT
WQ
------
DV
F
MMP
AP
L
GH
A
TG
FLHGVT
APF
LI
GA
R
S
VL
L
D
IF
----
TP
D
A
CLAL
L
E
Q
Q
R
C
T
CMLGA
T
PFV
Y
DL
LN
L
L
E
K
QP
AD
-
-----
-
LS
A
LRF
F
L
CGGT
TIPKK
V
A
R
E
-----
C
QQ
R
G
I
K
---
LL
SV
YG
S
TE
S
SPHA
V
V
N
L
--
D
D
P
L
-P
R
FMH
-
T
D
G
Y
A
A
A
GVE
IK
V
VDD
ARK
T
LP
P
G
C
EGE
--
-
EA
S
---
R
G
P
N
V
F
-------
MG
YF
DE
P
EL
TA
R
A
L
DEE
GWY
Y
SGD
LC
R
M
DE
A
GY
IK
ITGR
KK
D
I
I
V
RGGEN
I
S
SR
E
V
E
D
IL
LQ
HPKI
H
DA
C
VV
AM
PD
E
R
L
GE
RS
C
AYVVL
K
A
PHH
S
LS
L
EE
V
--
V
A
F
F
S
RK
R
V
AK
Y
K
Y
P
EH
I
VVI
E
K
LPRT
V
SGKI
QKFL
LRK
DI
fig|340197.3.peg.1839
Escherichia coli F11 (38-553/566)
LW
G
DAS
L
ADY
W
QQT
A
RAMP
DK
I
A
V
V
D
N
-
HG
A
T
----
Y
T
Y
S
A
L
D
HAAS
C
L
AN
WM
L
A
K
GI
E
S
GD
R
I
A
FQ
LP
GW
C
EF
T
V
IY
LAC
L
K
T
GAV
S
VP
L
LPSWRE
A
E
L
V
W
V
L
NK
C
QA
K
M
F-
--
--
F
A
P
T
LFK
Q
TR
PVDLILPL
Q
N
QLP
QL
Q
Q
I
V
G
---
VD
K
LA
--
PA
TS
S
L
S
LSQI
L
A
D
-------------------
N
T
P
--
L
TT
A
ITV
H
G
D
E
L
A
A
V
LFTSGT
E
G
L
PKGV
M
L
TH
N
N
I
L
ASERA
Y
C
A
R
L
NLT
WQ
------
DV
F
MMP
AP
L
GH
A
TG
FLHGVT
APF
LI
GA
R
S
VL
L
D
IF
----
TP
D
A
CLAL
L
E
Q
Q
R
C
T
CMLGA
T
PFV
Y
DL
LN
L
L
E
K
QP
AD
-
-----
-
LS
A
LRF
F
L
CGGT
TIPKK
V
A
R
E
-----
C
QQ
R
G
I
K
---
LL
SV
YG
S
TE
S
SPHA
V
V
N
L
--
D
D
P
L
-P
R
FMH
-
T
D
G
Y
A
A
A
GVE
IK
V
VDD
ARK
T
LP
P
G
C
EGE
--
-
EA
S
---
R
G
P
N
V
F
-------
MG
YF
DE
P
EL
TA
R
A
L
DEE
GWY
Y
SGD
LC
R
M
DE
A
GY
IK
ITGR
KK
D
I
I
V
RGGEN
I
S
SR
E
V
E
D
IL
LQ
HPKI
H
DA
C
VV
AM
PD
E
R
L
GE
RS
C
AYVVL
K
A
PHH
S
LS
L
EE
V
--
V
A
F
F
S
RK
R
V
AK
Y
K
Y
P
EH
I
VVI
E
K
LPRT
V
SGKI
QKFL
LRK
DI
fig|749531.3.peg.4837
Escherichia coli MS 69-1 (20-535/548)
LW
G
DAS
L
ADY
W
QQT
A
RAMP
DK
I
A
V
V
D
N
-
HG
AS
----
Y
T
Y
S
A
L
D
HAAS
C
L
AN
WM
L
A
K
GI
E
S
GD
R
I
A
FQ
LP
GW
C
EF
T
V
IY
LAC
L
KIGAV
S
VP
L
LPSWRE
A
E
L
V
W
V
L
NK
C
QA
K
M
F-
--
--
F
A
P
T
LFK
Q
TR
PVDLILPL
Q
N
QLP
QL
Q
Q
I
V
G
---
VD
K
LA
--
PA
TS
A
L
S
LSQI
IA
D
-------------------
N
T
P
--
L
TT
A
ITV
H
G
D
E
L
A
A
V
LFTSGT
E
G
L
PKGV
M
L
TH
N
N
I
L
ASERA
Y
C
A
R
L
NLT
WQ
------
DV
F
MMP
AP
L
GH
A
TG
FLHGVT
APF
LI
GA
R
S
VL
L
D
IF
----
TP
A
A
CLAL
L
E
Q
Q
R
C
T
CMLGA
T
PFV
Y
DL
LN
L
L
E
K
QP
AD
-
-----
-
LS
A
LRF
F
L
CGGT
TIPKK
V
A
R
E
-----
C
QQ
R
G
I
K
---
LL
SV
YG
S
TE
S
SPHA
V
V
N
L
--
D
D
P
L
-S
R
FMH
-
T
D
G
Y
A
V
A
GVE
IK
V
VDD
ARK
T
LP
P
G
C
EGE
--
-
EA
S
---
R
G
P
N
V
F
-------
MG
YF
DE
P
EL
TA
R
A
L
DEE
GWY
Y
SGD
LC
R
M
DE
A
GY
IK
ITGR
KK
D
I
I
V
RGGEN
I
S
SR
E
V
E
D
IL
LQ
HPKI
H
DA
C
VV
AM
PD
E
R
L
GE
RS
C
AYVVL
K
A
PHH
S
LS
L
EE
V
--
V
A
F
F
S
RK
R
IAK
Y
K
Y
P
EH
I
VVI
E
K
LPRT
V
SGKI
QKFL
LRK
DI
fig|585396.4.peg.2255
Escherichia coli O111:H- str. 11128 (20-535/548)
LW
G
DAS
L
ADY
W
QQT
A
RAMP
DK
I
A
V
V
D
N
-
HG
AS
----
Y
T
Y
S
A
L
D
HAAS
C
L
AN
WM
L
A
K
GI
E
S
GD
R
I
A
FQ
LP
GW
C
EF
T
V
IY
LAC
L
KIGAV
S
VP
L
LPSWRE
A
E
L
V
W
V
L
NK
C
QA
K
M
F-
--
--
F
A
P
T
LFK
Q
TR
PVDLILPL
Q
N
QLP
QL
Q
Q
I
V
G
---
VD
K
LA
--
PA
TS
S
L
S
LSQI
IA
D
-------------------
N
T
P
--
L
TT
A
ITT
H
G
D
E
L
A
A
V
LFTSG
I
E
G
L
PKGV
M
L
TH
N
N
I
L
ASERA
Y
C
A
R
L
NLT
WQ
------
DV
F
MMP
AP
L
GH
A
TG
FLHGVT
APF
LI
GA
R
S
VL
L
D
IF
----
TP
D
A
CLAL
L
E
Q
Q
R
C
T
CMLGA
T
PFV
Y
DL
LN
V
L
E
K
QP
AD
-
-----
-
LS
A
LRF
F
L
CGGT
TIPKK
V
A
R
E
-----
C
QQ
L
G
I
K
---
LL
SV
YG
S
TE
S
SPHA
V
V
N
L
--
D
D
P
L
-S
R
FMH
-
T
D
G
Y
A
A
A
GVE
IK
V
VDD
ARK
T
LP
P
G
C
EGE
--
-
EA
S
---
R
G
P
N
V
F
-------
MG
YF
DE
P
EL
TA
R
A
L
DEE
GWY
Y
SGD
LC
R
M
DE
A
GY
IK
ITGR
KK
D
I
I
V
RGGEN
I
S
SR
E
V
E
D
IL
LQ
HPKI
H
DA
C
VV
AM
PD
E
R
L
GE
RS
C
AYVVL
K
A
PHH
S
LS
L
EE
V
--
V
A
F
F
S
RK
R
V
AK
Y
K
Y
P
EH
I
VVI
E
K
LPRT
A
SGKI
QKFL
LRK
DI
fig|340185.3.peg.3640
Escherichia coli E22 (38-553/566)
LW
G
DAS
L
ADY
W
QQT
A
RAMP
DK
I
A
V
V
D
N
-
HG
AS
----
Y
T
Y
S
A
L
D
HAAS
C
L
AN
WM
L
A
K
GI
E
S
GD
R
I
A
FQ
LP
GW
C
EF
T
V
IY
LAC
L
KIGAV
S
VP
L
LPSWRE
A
E
L
V
W
V
L
NK
C
QA
K
M
F-
--
--
F
A
P
T
LFK
Q
TR
PVDLILPL
Q
N
QLP
QL
Q
Q
I
V
G
---
VD
K
LA
--
PA
TS
S
L
S
LSQI
IA
D
-------------------
N
T
S
--
L
TT
A
ITT
H
G
D
E
L
A
A
V
LFTSGT
E
G
L
PKGV
M
L
TH
N
N
I
L
ASERA
Y
C
V
R
L
NLT
WQ
------
DV
F
MMP
AP
L
GH
A
TG
FLHGVT
APF
LI
GA
R
S
VL
L
D
IF
----
TP
D
A
CLAL
L
E
Q
Q
R
C
T
CMLGA
T
PFV
Y
DL
LN
V
L
E
K
QP
AD
-
-----
-
LS
A
LRF
F
L
CGGT
TIPKK
V
A
R
E
-----
C
QQ
L
G
I
K
---
LL
SV
YG
S
TE
S
SPHA
V
V
N
L
--
D
D
P
L
-S
R
FMH
-
T
D
G
Y
A
A
A
GVE
IK
V
VDD
ARK
T
LP
P
G
C
EGE
--
-
EA
S
---
R
G
P
N
V
F
-------
MG
YF
DE
P
EL
TA
R
A
L
DEE
GWY
Y
SGD
LC
R
M
DE
A
GY
IK
ITGR
KK
D
I
I
V
RGGEN
I
S
SR
E
V
E
D
IL
LQ
HPKI
H
DA
C
VV
AM
PD
E
R
L
GE
RS
C
AYVVL
K
A
PHH
S
LS
L
EE
V
--
V
A
F
F
S
RK
R
V
AK
Y
K
Y
P
EH
I
VVI
E
K
LPRT
A
SGKI
QKFL
LRK
DI
fig|344601.3.peg.3833
Escherichia coli B171 (38-553/566)
LW
G
DAS
L
ADY
W
QQT
A
RAMP
DK
I
A
V
V
D
N
-
HG
AS
----
Y
T
Y
S
A
L
D
HAAS
C
L
AN
WM
L
A
K
GI
E
S
GD
R
I
A
FQ
LP
GW
C
EF
T
V
IY
LAC
L
KIGAV
S
VP
L
LPSWRE
A
E
L
V
W
V
L
NK
C
QA
K
M
F-
--
--
F
A
P
T
LFK
Q
TR
PVDLILPL
Q
N
QLP
QL
Q
Q
I
V
G
---
VD
K
LA
--
PA
TS
S
L
S
LSQI
IA
D
-------------------
N
T
S
--
L
TT
A
ITT
H
G
D
E
L
A
A
V
LFTSGT
E
G
L
PKGV
M
L
TH
N
N
I
L
ASERA
Y
C
V
R
L
NLT
WQ
------
DV
F
MMP
AP
L
GH
A
TG
FLHGVT
APF
LI
GA
R
S
VL
L
D
IF
----
TP
D
A
CLAL
L
E
Q
Q
R
C
T
CMLGA
T
PFV
Y
DL
LN
V
L
E
K
QP
AD
-
-----
-
LS
A
LRF
F
L
CGGT
TIPKK
V
A
R
E
-----
C
QQ
L
G
I
K
---
LL
SV
YG
S
TE
S
SPHA
V
V
N
L
--
D
D
P
L
-S
R
FMH
-
T
D
G
Y
A
A
A
GVE
IK
V
VDD
ARK
T
LP
P
G
C
EGE
--
-
EA
S
---
R
G
P
N
V
F
-------
MG
YF
DE
P
EL
TA
R
A
L
DEE
GWY
Y
SGD
LC
R
M
DE
A
GY
IK
ITGR
KK
D
I
I
V
RGGEN
I
S
SR
E
V
E
D
IL
LQ
HPKI
H
DA
C
VV
AM
PD
E
R
L
GE
RS
C
AYVVL
K
A
PHH
S
LS
L
EE
V
--
V
A
F
F
S
RK
R
V
AK
Y
K
Y
P
EH
I
VVI
E
K
LPRT
A
SGKI
QKCL
LRK
DI
fig|344601.5.peg.4014
Escherichia coli B171 (20-535/548)
LW
G
DAS
L
ADY
W
QQT
A
RAMP
DK
I
A
V
V
D
N
-
HG
AS
----
Y
T
Y
S
A
L
D
HAAS
C
L
AN
WM
L
A
K
GI
E
S
GD
R
I
A
FQ
LP
GW
C
EF
T
V
IY
LAC
L
KIGAV
S
VP
L
LPSWRE
A
E
L
V
W
V
L
NK
C
QA
K
M
F-
--
--
F
A
P
T
LFK
Q
TR
PVDLILPL
Q
N
QLP
QL
Q
Q
I
V
G
---
VD
K
LA
--
PA
TS
S
L
S
LSQI
IA
D
-------------------
N
T
S
--
L
TT
A
ITT
H
G
D
E
L
A
A
V
LFTSGT
E
G
L
PKGV
M
L
TH
N
N
I
L
ASERA
Y
C
V
R
L
NLT
WQ
------
DV
F
MMP
AP
L
GH
A
TG
FLHGVT
APF
LI
GA
R
S
VL
L
D
IF
----
TP
D
A
CLAL
L
E
Q
Q
R
C
T
CMLGA
T
PFV
Y
DL
LN
V
L
E
K
QP
AD
-
-----
-
LS
A
LRF
F
L
CGGT
TIPKK
V
A
R
E
-----
C
QQ
L
G
I
K
---
LL
SV
YG
S
TE
S
SPHA
V
V
N
L
--
D
D
P
L
-S
R
FMH
-
T
D
G
Y
A
A
A
GVE
IK
V
VDD
ARK
T
LP
P
G
C
EGE
--
-
EA
S
---
R
G
P
N
V
F
-------
MG
YF
DE
P
EL
TA
R
A
L
DEE
GWY
Y
SGD
LC
R
M
DE
A
GY
IK
ITGR
KK
D
I
I
V
RGGEN
I
S
SR
E
V
E
D
IL
LQ
HPKI
H
DA
C
VV
AM
PD
E
R
L
GE
RS
C
AYVVL
K
A
PHH
S
LS
L
EE
V
--
V
A
F
F
S
RK
R
V
AK
Y
K
Y
P
EH
I
VVI
E
K
LPRT
A
SGKI
QKCL
LRK
DI
fig|340185.4.peg.3828
Escherichia coli E22 (20-535/548)
LW
G
DAS
L
ADY
W
QQT
A
RAMP
DK
I
A
V
V
D
N
-
HG
AS
----
Y
T
Y
S
A
L
D
HAAS
C
L
AN
WM
L
A
K
GI
E
S
GD
R
I
A
FQ
LP
GW
C
EF
T
V
IY
LAC
L
KIGAV
S
VP
L
LPSWRE
A
E
L
V
W
V
L
NK
C
QA
K
M
F-
--
--
F
A
P
T
LFK
Q
TR
PVDLILPL
Q
N
QLP
QL
Q
Q
I
V
G
---
VD
K
LA
--
PA
TS
S
L
S
LSQI
IA
D
-------------------
N
T
S
--
L
TT
A
ITT
H
G
D
E
L
A
A
V
LFTSGT
E
G
L
PKGV
M
L
TH
N
N
I
L
ASERA
Y
C
V
R
L
NLT
WQ
------
DV
F
MMP
AP
L
GH
A
TG
FLHGVT
APF
LI
GA
R
S
VL
L
D
IF
----
TP
D
A
CLAL
L
E
Q
Q
R
C
T
CMLGA
T
PFV
Y
DL
LN
V
L
E
K
QP
AD
-
-----
-
LS
A
LRF
F
L
CGGT
TIPKK
V
A
R
E
-----
C
QQ
L
G
I
K
---
LL
SV
YG
S
TE
S
SPHA
V
V
N
L
--
D
D
P
L
-S
R
FMH
-
T
D
G
Y
A
A
A
GVE
IK
V
VDD
ARK
T
LP
P
G
C
EGE
--
-
EA
S
---
R
G
P
N
V
F
-------
MG
YF
DE
P
EL
TA
R
A
L
DEE
GWY
Y
SGD
LC
R
M
DE
A
GY
IK
ITGR
KK
D
I
I
V
RGGEN
I
S
SR
E
V
E
D
IL
LQ
HPKI
H
DA
C
VV
AM
PD
E
R
L
GE
RS
C
AYVVL
K
A
PHH
S
LS
L
EE
V
--
V
A
F
F
S
RK
R
V
AK
Y
K
Y
P
EH
I
VVI
E
K
LPRT
A
SGKI
QKFL
LRK
DI
fig|585395.4.peg.1932
Escherichia coli O103:H2 str. 12009 (20-535/548)
LW
G
DAS
L
ADY
W
QQT
A
RAMP
DK
I
A
V
V
D
N
-
HG
AS
----
Y
T
Y
S
A
L
D
HAAS
C
L
AN
WM
L
A
K
GI
E
S
GD
R
I
A
FQ
LP
GW
C
EF
T
V
IY
LAC
L
KIGAV
S
VP
L
LPSWRE
A
E
L
V
W
V
L
NK
C
QA
K
M
F-
--
--
F
A
P
T
LFK
Q
TR
PVDLILPL
Q
N
QLP
QL
Q
Q
I
V
G
---
VD
K
LA
--
PA
TS
S
L
S
LSQI
IA
D
-------------------
N
T
S
--
L
TT
A
ITT
H
G
D
E
L
A
A
V
LFTSGT
E
G
L
PKGV
M
L
TH
N
N
I
L
ASERA
Y
C
V
R
L
NLT
WQ
------
DV
F
MMP
AP
L
GH
A
TG
FLHGVT
APF
LI
GA
R
S
VL
L
D
IF
----
TP
D
A
CLAL
L
E
Q
Q
R
C
T
CMLGA
T
PFV
Y
DL
LN
V
L
E
K
QP
AD
-
-----
-
LS
A
LRF
F
L
CGGT
TIPKK
V
A
R
E
-----
C
QQ
L
G
I
K
---
LL
SV
YG
S
TE
S
SPHA
V
V
N
L
--
D
D
P
L
-S
R
FMH
-
T
D
G
Y
A
A
A
GVE
IK
V
VDD
ARK
T
LP
P
G
C
EGE
--
-
EA
S
---
R
G
P
N
V
F
-------
MG
YF
DE
P
EL
TA
R
A
L
DEE
GWY
Y
SGD
LC
R
M
DE
A
GY
IK
ITGR
KK
D
I
I
V
RGGEN
I
S
SR
E
V
E
D
IL
LQ
HPKI
H
DA
C
VV
AM
PD
E
R
L
GE
RS
C
AYVVL
K
A
PHH
S
LS
L
EE
V
--
V
A
F
F
S
RK
R
V
AK
Y
K
Y
P
EH
I
VVI
E
K
LPRT
A
SGKI
QKFL
LRK
DI
fig|753642.3.peg.3263
Escherichia coli NC101 (20-535/548)
LW
G
DAS
L
ADY
W
QQT
A
RAMP
DK
I
A
V
V
D
N
-
HG
A
T
----
Y
T
Y
S
A
L
D
HAAS
C
L
AN
WM
L
A
K
GI
E
S
GD
R
I
A
FQ
LP
GW
C
EF
T
V
IY
LAC
L
K
T
GAV
S
VP
L
LPSWRE
A
E
L
V
W
V
L
NK
C
QA
K
M
F-
--
--
F
A
P
T
LFK
Q
TR
PVDLILPL
Q
N
QLP
QL
Q
Q
I
V
G
---
VD
K
LA
--
PA
TS
S
L
S
LSQI
L
A
D
-------------------
N
T
P
--
L
TT
A
ITT
H
G
D
E
L
A
A
V
LFTSGT
E
G
L
PKGV
M
L
TH
N
N
I
L
ASERA
Y
C
A
R
L
NLT
WQ
------
DV
F
MMP
AP
L
GH
A
TG
FLHGVT
APF
LI
GA
R
S
VL
L
D
IF
----
TP
D
A
CLAL
L
E
Q
Q
R
C
T
CMLGA
T
PFV
Y
DL
LN
L
L
E
K
QP
AD
-
-----
-
LS
A
LRF
F
L
CGGT
TIPKK
V
A
R
E
-----
C
QQ
R
G
I
K
---
LL
SV
YG
S
TE
S
SPHA
V
V
N
L
--
D
D
P
L
-P
R
FMH
-
T
D
G
Y
A
A
A
GVE
IK
V
VDD
AHK
T
LP
P
G
C
EGE
--
-
EA
S
---
R
G
P
N
V
F
-------
MG
YF
DE
P
EL
TA
R
A
L
DEE
GWY
Y
SGD
LC
R
M
DE
A
GY
IK
ITGR
KK
D
I
I
V
RGGEN
I
S
SR
E
V
E
D
IL
LQ
HPKI
H
DA
C
VV
AM
PD
E
R
L
GE
RS
C
AYVVL
K
A
PHH
S
LS
L
EE
V
--
V
V
F
F
S
RK
R
V
AK
Y
K
Y
P
EH
I
VVI
E
K
LPRT
V
SGKI
QKFL
LRK
DI
fig|525281.3.peg.802
Escherichia coli 83972 (20-535/548)
LW
G
DAS
L
ADY
W
QQT
A
RAMP
DK
I
A
V
V
D
N
-
HG
A
T
----
Y
T
Y
S
A
L
D
HAAS
C
L
AN
WM
L
A
K
GI
E
S
GD
R
I
A
FQ
LP
GW
C
EF
T
V
IY
LAC
L
K
T
GAV
S
VP
L
LPSWRE
A
E
L
V
W
V
L
NK
C
QA
K
M
F-
--
--
F
A
P
T
LFK
Q
TR
PVDLILPL
Q
N
QLP
QL
Q
Q
I
V
G
---
VD
K
LA
--
PA
TS
S
L
S
LSQI
L
A
D
-------------------
N
T
P
--
L
TT
A
ITT
H
G
D
E
L
A
A
V
LFTSGT
E
G
L
PKGV
M
L
TH
N
N
I
L
ASERA
Y
C
A
R
L
NLT
WQ
------
DV
F
MMP
AP
L
GH
A
TG
FLHGVT
APF
LI
GA
R
S
VL
L
D
IF
----
TP
D
A
CLAL
L
E
Q
Q
R
C
T
CMLGA
T
PFV
Y
DL
LN
L
L
E
K
QP
AD
-
-----
-
LS
A
LRF
F
L
CGGT
TIPKK
V
A
R
E
-----
C
QQ
R
G
I
K
---
LL
SV
YG
S
TE
S
SPHA
V
V
N
L
--
D
D
P
L
-P
R
FMH
-
T
D
G
Y
A
A
A
GVE
IK
V
VDD
ARK
T
LP
P
G
C
EGE
--
-
EA
S
---
R
G
P
N
V
F
-------
MG
YF
DE
P
EL
TA
R
A
L
DEE
GWY
Y
SGD
LC
R
M
DE
A
GY
IK
ITGR
KK
D
I
I
V
RGGEN
I
S
SR
E
V
E
D
IL
LQ
HPKI
H
DA
C
VV
AM
PD
E
R
L
GE
RS
C
AYVVL
K
A
PHH
S
LS
L
EE
V
--
V
A
F
F
S
RK
R
V
AK
Y
K
Y
P
EH
I
VVI
E
K
LPRT
V
SGKI
QKFL
LRK
DI
fig|655817.3.peg.2047
Escherichia coli ABU 83972 (20-535/548)
LW
G
DAS
L
ADY
W
QQT
A
RAMP
DK
I
A
V
V
D
N
-
HG
A
T
----
Y
T
Y
S
A
L
D
HAAS
C
L
AN
WM
L
A
K
GI
E
S
GD
R
I
A
FQ
LP
GW
C
EF
T
V
IY
LAC
L
K
T
GAV
S
VP
L
LPSWRE
A
E
L
V
W
V
L
NK
C
QA
K
M
F-
--
--
F
A
P
T
LFK
Q
TR
PVDLILPL
Q
N
QLP
QL
Q
Q
I
V
G
---
VD
K
LA
--
PA
TS
S
L
S
LSQI
L
A
D
-------------------
N
T
P
--
L
TT
A
ITT
H
G
D
E
L
A
A
V
LFTSGT
E
G
L
PKGV
M
L
TH
N
N
I
L
ASERA
Y
C
A
R
L
NLT
WQ
------
DV
F
MMP
AP
L
GH
A
TG
FLHGVT
APF
LI
GA
R
S
VL
L
D
IF
----
TP
D
A
CLAL
L
E
Q
Q
R
C
T
CMLGA
T
PFV
Y
DL
LN
L
L
E
K
QP
AD
-
-----
-
LS
A
LRF
F
L
CGGT
TIPKK
V
A
R
E
-----
C
QQ
R
G
I
K
---
LL
SV
YG
S
TE
S
SPHA
V
V
N
L
--
D
D
P
L
-P
R
FMH
-
T
D
G
Y
A
A
A
GVE
IK
V
VDD
ARK
T
LP
P
G
C
EGE
--
-
EA
S
---
R
G
P
N
V
F
-------
MG
YF
DE
P
EL
TA
R
A
L
DEE
GWY
Y
SGD
LC
R
M
DE
A
GY
IK
ITGR
KK
D
I
I
V
RGGEN
I
S
SR
E
V
E
D
IL
LQ
HPKI
H
DA
C
VV
AM
PD
E
R
L
GE
RS
C
AYVVL
K
A
PHH
S
LS
L
EE
V
--
V
A
F
F
S
RK
R
V
AK
Y
K
Y
P
EH
I
VVI
E
K
LPRT
V
SGKI
QKFL
LRK
DI
fig|405955.13.peg.1790
Escherichia coli APEC O1 (20-535/548)
LW
G
DAS
L
ADY
W
QQT
A
RAMP
DK
I
A
V
V
D
N
-
HG
A
T
----
Y
T
Y
S
A
L
D
HAAS
C
L
AN
WM
L
A
K
GI
E
S
GD
R
I
A
FQ
LP
GW
C
EF
T
V
IY
LAC
L
K
T
GAV
S
VP
L
LPSWRE
A
E
L
V
W
V
L
NK
C
QA
K
M
F-
--
--
F
A
P
T
LFK
Q
TR
PVDLILPL
Q
N
QLP
QL
Q
Q
I
V
G
---
VD
K
LA
--
PA
TS
S
L
S
LSQI
L
A
D
-------------------
N
T
P
--
L
TT
A
ITT
H
G
D
E
L
A
A
V
LFTSGT
E
G
L
PKGV
M
L
TH
N
N
I
L
ASERA
Y
C
A
R
L
NLT
WQ
------
DV
F
MMP
AP
L
GH
A
TG
FLHGVT
APF
LI
GA
R
S
VL
L
D
IF
----
TP
D
A
CLAL
L
E
Q
Q
R
C
T
CMLGA
T
PFV
Y
DL
LN
L
L
E
K
QP
AD
-
-----
-
LS
A
LRF
F
L
CGGT
TIPKK
V
A
R
E
-----
C
QQ
R
G
I
K
---
LL
SV
YG
S
TE
S
SPHA
V
V
N
L
--
D
D
P
L
-P
R
FMH
-
T
D
G
Y
A
A
A
GVE
IK
V
VDD
ARK
T
LP
P
G
C
EGE
--
-
EA
S
---
R
G
P
N
V
F
-------
MG
YF
DE
P
EL
TA
R
A
L
DEE
GWY
Y
SGD
LC
R
M
DE
A
GY
IK
ITGR
KK
D
I
I
V
RGGEN
I
S
SR
E
V
E
D
IL
LQ
HPKI
H
DA
C
VV
AM
PD
E
R
L
GE
RS
C
AYVVL
K
A
PHH
S
LS
L
EE
V
--
V
A
F
F
S
RK
R
V
AK
Y
K
Y
P
EH
I
VVI
E
K
LPRT
V
SGKI
QKFL
LRK
DI
fig|405955.9.peg.1461
Escherichia coli APEC O1 (38-553/566)
LW
G
DAS
L
ADY
W
QQT
A
RAMP
DK
I
A
V
V
D
N
-
HG
A
T
----
Y
T
Y
S
A
L
D
HAAS
C
L
AN
WM
L
A
K
GI
E
S
GD
R
I
A
FQ
LP
GW
C
EF
T
V
IY
LAC
L
K
T
GAV
S
VP
L
LPSWRE
A
E
L
V
W
V
L
NK
C
QA
K
M
F-
--
--
F
A
P
T
LFK
Q
TR
PVDLILPL
Q
N
QLP
QL
Q
Q
I
V
G
---
VD
K
LA
--
PA
TS
S
L
S
LSQI
L
A
D
-------------------
N
T
P
--
L
TT
A
ITT
H
G
D
E
L
A
A
V
LFTSGT
E
G
L
PKGV
M
L
TH
N
N
I
L
ASERA
Y
C
A
R
L
NLT
WQ
------
DV
F
MMP
AP
L
GH
A
TG
FLHGVT
APF
LI
GA
R
S
VL
L
D
IF
----
TP
D
A
CLAL
L
E
Q
Q
R
C
T
CMLGA
T
PFV
Y
DL
LN
L
L
E
K
QP
AD
-
-----
-
LS
A
LRF
F
L
CGGT
TIPKK
V
A
R
E
-----
C
QQ
R
G
I
K
---
LL
SV
YG
S
TE
S
SPHA
V
V
N
L
--
D
D
P
L
-P
R
FMH
-
T
D
G
Y
A
A
A
GVE
IK
V
VDD
ARK
T
LP
P
G
C
EGE
--
-
EA
S
---
R
G
P
N
V
F
-------
MG
YF
DE
P
EL
TA
R
A
L
DEE
GWY
Y
SGD
LC
R
M
DE
A
GY
IK
ITGR
KK
D
I
I
V
RGGEN
I
S
SR
E
V
E
D
IL
LQ
HPKI
H
DA
C
VV
AM
PD
E
R
L
GE
RS
C
AYVVL
K
A
PHH
S
LS
L
EE
V
--
V
A
F
F
S
RK
R
V
AK
Y
K
Y
P
EH
I
VVI
E
K
LPRT
V
SGKI
QKFL
LRK
DI
fig|199310.1.peg.2035
Escherichia coli CFT073 (38-553/566)
LW
G
DAS
L
ADY
W
QQT
A
RAMP
DK
I
A
V
V
D
N
-
HG
A
T
----
Y
T
Y
S
A
L
D
HAAS
C
L
AN
WM
L
A
K
GI
E
S
GD
R
I
A
FQ
LP
GW
C
EF
T
V
IY
LAC
L
K
T
GAV
S
VP
L
LPSWRE
A
E
L
V
W
V
L
NK
C
QA
K
M
F-
--
--
F
A
P
T
LFK
Q
TR
PVDLILPL
Q
N
QLP
QL
Q
Q
I
V
G
---
VD
K
LA
--
PA
TS
S
L
S
LSQI
L
A
D
-------------------
N
T
P
--
L
TT
A
ITT
H
G
D
E
L
A
A
V
LFTSGT
E
G
L
PKGV
M
L
TH
N
N
I
L
ASERA
Y
C
A
R
L
NLT
WQ
------
DV
F
MMP
AP
L
GH
A
TG
FLHGVT
APF
LI
GA
R
S
VL
L
D
IF
----
TP
D
A
CLAL
L
E
Q
Q
R
C
T
CMLGA
T
PFV
Y
DL
LN
L
L
E
K
QP
AD
-
-----
-
LS
A
LRF
F
L
CGGT
TIPKK
V
A
R
E
-----
C
QQ
R
G
I
K
---
LL
SV
YG
S
TE
S
SPHA
V
V
N
L
--
D
D
P
L
-P
R
FMH
-
T
D
G
Y
A
A
A
GVE
IK
V
VDD
ARK
T
LP
P
G
C
EGE
--
-
EA
S
---
R
G
P
N
V
F
-------
MG
YF
DE
P
EL
TA
R
A
L
DEE
GWY
Y
SGD
LC
R
M
DE
A
GY
IK
ITGR
KK
D
I
I
V
RGGEN
I
S
SR
E
V
E
D
IL
LQ
HPKI
H
DA
C
VV
AM
PD
E
R
L
GE
RS
C
AYVVL
K
A
PHH
S
LS
L
EE
V
--
V
A
F
F
S
RK
R
V
AK
Y
K
Y
P
EH
I
VVI
E
K
LPRT
V
SGKI
QKFL
LRK
DI
fig|199310.4.peg.1963
Escherichia coli CFT073 (20-535/548)
LW
G
DAS
L
ADY
W
QQT
A
RAMP
DK
I
A
V
V
D
N
-
HG
A
T
----
Y
T
Y
S
A
L
D
HAAS
C
L
AN
WM
L
A
K
GI
E
S
GD
R
I
A
FQ
LP
GW
C
EF
T
V
IY
LAC
L
K
T
GAV
S
VP
L
LPSWRE
A
E
L
V
W
V
L
NK
C
QA
K
M
F-
--
--
F
A
P
T
LFK
Q
TR
PVDLILPL
Q
N
QLP
QL
Q
Q
I
V
G
---
VD
K
LA
--
PA
TS
S
L
S
LSQI
L
A
D
-------------------
N
T
P
--
L
TT
A
ITT
H
G
D
E
L
A
A
V
LFTSGT
E
G
L
PKGV
M
L
TH
N
N
I
L
ASERA
Y
C
A
R
L
NLT
WQ
------
DV
F
MMP
AP
L
GH
A
TG
FLHGVT
APF
LI
GA
R
S
VL
L
D
IF
----
TP
D
A
CLAL
L
E
Q
Q
R
C
T
CMLGA
T
PFV
Y
DL
LN
L
L
E
K
QP
AD
-
-----
-
LS
A
LRF
F
L
CGGT
TIPKK
V
A
R
E
-----
C
QQ
R
G
I
K
---
LL
SV
YG
S
TE
S
SPHA
V
V
N
L
--
D
D
P
L
-P
R
FMH
-
T
D
G
Y
A
A
A
GVE
IK
V
VDD
ARK
T
LP
P
G
C
EGE
--
-
EA
S
---
R
G
P
N
V
F
-------
MG
YF
DE
P
EL
TA
R
A
L
DEE
GWY
Y
SGD
LC
R
M
DE
A
GY
IK
ITGR
KK
D
I
I
V
RGGEN
I
S
SR
E
V
E
D
IL
LQ
HPKI
H
DA
C
VV
AM
PD
E
R
L
GE
RS
C
AYVVL
K
A
PHH
S
LS
L
EE
V
--
V
A
F
F
S
RK
R
V
AK
Y
K
Y
P
EH
I
VVI
E
K
LPRT
V
SGKI
QKFL
LRK
DI
fig|585397.7.peg.1926
Escherichia coli ED1a (20-535/548)
LW
G
DAS
L
ADY
W
QQT
A
RAMP
DK
I
A
V
V
D
N
-
HG
A
T
----
Y
T
Y
S
A
L
D
HAAS
C
L
AN
WM
L
A
K
GI
E
S
GD
R
I
A
FQ
LP
GW
C
EF
T
V
IY
LAC
L
K
T
GAV
S
VP
L
LPSWRE
A
E
L
V
W
V
L
NK
C
QA
K
M
F-
--
--
F
A
P
T
LFK
Q
TR
PVDLILPL
Q
N
QLP
QL
Q
Q
I
V
G
---
VD
K
LA
--
PA
TS
S
L
S
LSQI
L
A
D
-------------------
N
T
P
--
L
TT
A
ITT
H
G
D
E
L
A
A
V
LFTSGT
E
G
L
PKGV
M
L
TH
N
N
I
L
ASERA
Y
C
A
R
L
NLT
WQ
------
DV
F
MMP
AP
L
GH
A
TG
FLHGVT
APF
LI
GA
R
S
VL
L
D
IF
----
TP
D
A
CLAL
L
E
Q
Q
R
C
T
CMLGA
T
PFV
Y
DL
LN
L
L
E
K
QP
AD
-
-----
-
LS
A
LRF
F
L
CGGT
TIPKK
V
A
R
E
-----
C
QQ
R
G
I
K
---
LL
SV
YG
S
TE
S
SPHA
V
V
N
L
--
D
D
P
L
-P
R
FMH
-
T
D
G
Y
A
A
A
GVE
IK
V
VDD
ARK
T
LP
P
G
C
EGE
--
-
EA
S
---
R
G
P
N
V
F
-------
MG
YF
DE
P
EL
TA
R
A
L
DEE
GWY
Y
SGD
LC
R
M
DE
A
GY
IK
ITGR
KK
D
I
I
V
RGGEN
I
S
SR
E
V
E
D
IL
LQ
HPKI
H
DA
C
VV
AM
PD
E
R
L
GE
RS
C
AYVVL
K
A
PHH
S
LS
L
EE
V
--
V
A
F
F
S
RK
R
V
AK
Y
K
Y
P
EH
I
VVI
E
K
LPRT
V
SGKI
QKFL
LRK
DI
fig|585397.9.peg.1921
Escherichia coli ED1a (20-535/548)
LW
G
DAS
L
ADY
W
QQT
A
RAMP
DK
I
A
V
V
D
N
-
HG
A
T
----
Y
T
Y
S
A
L
D
HAAS
C
L
AN
WM
L
A
K
GI
E
S
GD
R
I
A
FQ
LP
GW
C
EF
T
V
IY
LAC
L
K
T
GAV
S
VP
L
LPSWRE
A
E
L
V
W
V
L
NK
C
QA
K
M
F-
--
--
F
A
P
T
LFK
Q
TR
PVDLILPL
Q
N
QLP
QL
Q
Q
I
V
G
---
VD
K
LA
--
PA
TS
S
L
S
LSQI
L
A
D
-------------------
N
T
P
--
L
TT
A
ITT
H
G
D
E
L
A
A
V
LFTSGT
E
G
L
PKGV
M
L
TH
N
N
I
L
ASERA
Y
C
A
R
L
NLT
WQ
------
DV
F
MMP
AP
L
GH
A
TG
FLHGVT
APF
LI
GA
R
S
VL
L
D
IF
----
TP
D
A
CLAL
L
E
Q
Q
R
C
T
CMLGA
T
PFV
Y
DL
LN
L
L
E
K
QP
AD
-
-----
-
LS
A
LRF
F
L
CGGT
TIPKK
V
A
R
E
-----
C
QQ
R
G
I
K
---
LL
SV
YG
S
TE
S
SPHA
V
V
N
L
--
D
D
P
L
-P
R
FMH
-
T
D
G
Y
A
A
A
GVE
IK
V
VDD
ARK
T
LP
P
G
C
EGE
--
-
EA
S
---
R
G
P
N
V
F
-------
MG
YF
DE
P
EL
TA
R
A
L
DEE
GWY
Y
SGD
LC
R
M
DE
A
GY
IK
ITGR
KK
D
I
I
V
RGGEN
I
S
SR
E
V
E
D
IL
LQ
HPKI
H
DA
C
VV
AM
PD
E
R
L
GE
RS
C
AYVVL
K
A
PHH
S
LS
L
EE
V
--
V
A
F
F
S
RK
R
V
AK
Y
K
Y
P
EH
I
VVI
E
K
LPRT
V
SGKI
QKFL
LRK
DI
fig|714962.3.peg.1856
Escherichia coli IHE3034 (20-535/548)
LW
G
DAS
L
ADY
W
QQT
A
RAMP
DK
I
A
V
V
D
N
-
HG
A
T
----
Y
T
Y
S
A
L
D
HAAS
C
L
AN
WM
L
A
K
GI
E
S
GD
R
I
A
FQ
LP
GW
C
EF
T
V
IY
LAC
L
K
T
GAV
S
VP
L
LPSWRE
A
E
L
V
W
V
L
NK
C
QA
K
M
F-
--
--
F
A
P
T
LFK
Q
TR
PVDLILPL
Q
N
QLP
QL
Q
Q
I
V
G
---
VD
K
LA
--
PA
TS
S
L
S
LSQI
L
A
D
-------------------
N
T
P
--
L
TT
A
ITT
H
G
D
E
L
A
A
V
LFTSGT
E
G
L
PKGV
M
L
TH
N
N
I
L
ASERA
Y
C
A
R
L
NLT
WQ
------
DV
F
MMP
AP
L
GH
A
TG
FLHGVT
APF
LI
GA
R
S
VL
L
D
IF
----
TP
D
A
CLAL
L
E
Q
Q
R
C
T
CMLGA
T
PFV
Y
DL
LN
L
L
E
K
QP
AD
-
-----
-
LS
A
LRF
F
L
CGGT
TIPKK
V
A
R
E
-----
C
QQ
R
G
I
K
---
LL
SV
YG
S
TE
S
SPHA
V
V
N
L
--
D
D
P
L
-P
R
FMH
-
T
D
G
Y
A
A
A
GVE
IK
V
VDD
ARK
T
LP
P
G
C
EGE
--
-
EA
S
---
R
G
P
N
V
F
-------
MG
YF
DE
P
EL
TA
R
A
L
DEE
GWY
Y
SGD
LC
R
M
DE
A
GY
IK
ITGR
KK
D
I
I
V
RGGEN
I
S
SR
E
V
E
D
IL
LQ
HPKI
H
DA
C
VV
AM
PD
E
R
L
GE
RS
C
AYVVL
K
A
PHH
S
LS
L
EE
V
--
V
A
F
F
S
RK
R
V
AK
Y
K
Y
P
EH
I
VVI
E
K
LPRT
V
SGKI
QKFL
LRK
DI
fig|749546.3.peg.4514
Escherichia coli MS 185-1 (20-535/548)
LW
G
DAS
L
ADY
W
QQT
A
RAMP
DK
I
A
V
V
D
N
-
HG
A
T
----
Y
T
Y
S
A
L
D
HAAS
C
L
AN
WM
L
A
K
GI
E
S
GD
R
I
A
FQ
LP
GW
C
EF
T
V
IY
LAC
L
K
T
GAV
S
VP
L
LPSWRE
A
E
L
V
W
V
L
NK
C
QA
K
M
F-
--
--
F
A
P
T
LFK
Q
TR
PVDLILPL
Q
N
QLP
QL
Q
Q
I
V
G
---
VD
K
LA
--
PA
TS
S
L
S
LSQI
L
A
D
-------------------
N
T
P
--
L
TT
A
ITT
H
G
D
E
L
A
A
V
LFTSGT
E
G
L
PKGV
M
L
TH
N
N
I
L
ASERA
Y
C
A
R
L
NLT
WQ
------
DV
F
MMP
AP
L
GH
A
TG
FLHGVT
APF
LI
GA
R
S
VL
L
D
IF
----
TP
D
A
CLAL
L
E
Q
Q
R
C
T
CMLGA
T
PFV
Y
DL
LN
L
L
E
K
QP
AD
-
-----
-
LS
A
LRF
F
L
CGGT
TIPKK
V
A
R
E
-----
C
QQ
R
G
I
K
---
LL
SV
YG
S
TE
S
SPHA
V
V
N
L
--
D
D
P
L
-P
R
FMH
-
T
D
G
Y
A
A
A
GVE
IK
V
VDD
ARK
T
LP
P
G
C
EGE
--
-
EA
S
---
R
G
P
N
V
F
-------
MG
YF
DE
P
EL
TA
R
A
L
DEE
GWY
Y
SGD
LC
R
M
DE
A
GY
IK
ITGR
KK
D
I
I
V
RGGEN
I
S
SR
E
V
E
D
IL
LQ
HPKI
H
DA
C
VV
AM
PD
E
R
L
GE
RS
C
AYVVL
K
A
PHH
S
LS
L
EE
V
--
V
A
F
F
S
RK
R
V
AK
Y
K
Y
P
EH
I
VVI
E
K
LPRT
V
SGKI
QKFL
LRK
DI
fig|749528.3.peg.4834
Escherichia coli MS 45-1 (20-535/548)
LW
G
DAS
L
ADY
W
QQT
A
RAMP
DK
I
A
V
V
D
N
-
HG
A
T
----
Y
T
Y
S
A
L
D
HAAS
C
L
AN
WM
L
A
K
GI
E
S
GD
R
I
A
FQ
LP
GW
C
EF
T
V
IY
LAC
L
K
T
GAV
S
VP
L
LPSWRE
A
E
L
V
W
V
L
NK
C
QA
K
M
F-
--
--
F
A
P
T
LFK
Q
TR
PVDLILPL
Q
N
QLP
QL
Q
Q
I
V
G
---
VD
K
LA
--
PA
TS
S
L
S
LSQI
L
A
D
-------------------
N
T
P
--
L
TT
A
ITT
H
G
D
E
L
A
A
V
LFTSGT
E
G
L
PKGV
M
L
TH
N
N
I
L
ASERA
Y
C
A
R
L
NLT
WQ
------
DV
F
MMP
AP
L
GH
A
TG
FLHGVT
APF
LI
GA
R
S
VL
L
D
IF
----
TP
D
A
CLAL
L
E
Q
Q
R
C
T
CMLGA
T
PFV
Y
DL
LN
L
L
E
K
QP
AD
-
-----
-
LS
A
LRF
F
L
CGGT
TIPKK
V
A
R
E
-----
C
QQ
R
G
I
K
---
LL
SV
YG
S
TE
S
SPHA
V
V
N
L
--
D
D
P
L
-P
R
FMH
-
T
D
G
Y
A
A
A
GVE
IK
V
VDD
ARK
T
LP
P
G
C
EGE
--
-
EA
S
---
R
G
P
N
V
F
-------
MG
YF
DE
P
EL
TA
R
A
L
DEE
GWY
Y
SGD
LC
R
M
DE
A
GY
IK
ITGR
KK
D
I
I
V
RGGEN
I
S
SR
E
V
E
D
IL
LQ
HPKI
H
DA
C
VV
AM
PD
E
R
L
GE
RS
C
AYVVL
K
A
PHH
S
LS
L
EE
V
--
V
A
F
F
S
RK
R
V
AK
Y
K
Y
P
EH
I
VVI
E
K
LPRT
V
SGKI
QKFL
LRK
DI
fig|585035.6.peg.1742
Escherichia coli S88 (20-535/548)
LW
G
DAS
L
ADY
W
QQT
A
RAMP
DK
I
A
V
V
D
N
-
HG
A
T
----
Y
T
Y
S
A
L
D
HAAS
C
L
AN
WM
L
A
K
GI
E
S
GD
R
I
A
FQ
LP
GW
C
EF
T
V
IY
LAC
L
K
T
GAV
S
VP
L
LPSWRE
A
E
L
V
W
V
L
NK
C
QA
K
M
F-
--
--
F
A
P
T
LFK
Q
TR
PVDLILPL
Q
N
QLP
QL
Q
Q
I
V
G
---
VD
K
LA
--
PA
TS
S
L
S
LSQI
L
A
D
-------------------
N
T
P
--
L
TT
A
ITT
H
G
D
E
L
A
A
V
LFTSGT
E
G
L
PKGV
M
L
TH
N
N
I
L
ASERA
Y
C
A
R
L
NLT
WQ
------
DV
F
MMP
AP
L
GH
A
TG
FLHGVT
APF
LI
GA
R
S
VL
L
D
IF
----
TP
D
A
CLAL
L
E
Q
Q
R
C
T
CMLGA
T
PFV
Y
DL
LN
L
L
E
K
QP
AD
-
-----
-
LS
A
LRF
F
L
CGGT
TIPKK
V
A
R
E
-----
C
QQ
R
G
I
K
---
LL
SV
YG
S
TE
S
SPHA
V
V
N
L
--
D
D
P
L
-P
R
FMH
-
T
D
G
Y
A
A
A
GVE
IK
V
VDD
ARK
T
LP
P
G
C
EGE
--
-
EA
S
---
R
G
P
N
V
F
-------
MG
YF
DE
P
EL
TA
R
A
L
DEE
GWY
Y
SGD
LC
R
M
DE
A
GY
IK
ITGR
KK
D
I
I
V
RGGEN
I
S
SR
E
V
E
D
IL
LQ
HPKI
H
DA
C
VV
AM
PD
E
R
L
GE
RS
C
AYVVL
K
A
PHH
S
LS
L
EE
V
--
V
A
F
F
S
RK
R
V
AK
Y
K
Y
P
EH
I
VVI
E
K
LPRT
V
SGKI
QKFL
LRK
DI
fig|431946.3.peg.1622
Escherichia coli SE15 (20-535/548)
LW
G
DAS
L
ADY
W
QQT
A
RAMP
DK
I
A
V
V
D
N
-
HG
A
T
----
Y
T
Y
S
A
L
D
HAAS
C
L
AN
WM
L
A
K
GI
E
S
GD
R
I
A
FQ
LP
GW
C
EF
T
V
IY
LAC
L
K
T
GAV
S
VP
L
LPSWRE
A
E
L
V
W
V
L
NK
C
QA
K
M
F-
--
--
F
A
P
T
LFK
Q
TR
PVDLILPL
Q
N
QLP
QL
Q
Q
I
V
G
---
VD
K
LA
--
PA
TS
S
L
S
LSQI
L
A
D
-------------------
N
T
P
--
L
TT
A
ITT
H
G
D
E
L
A
A
V
LFTSGT
E
G
L
PKGV
M
L
TH
N
N
I
L
ASERA
Y
C
A
R
L
NLT
WQ
------
DV
F
MMP
AP
L
GH
A
TG
FLHGVT
APF
LI
GA
R
S
VL
L
D
IF
----
TP
D
A
CLAL
L
E
Q
Q
R
C
T
CMLGA
T
PFV
Y
DL
LN
L
L
E
K
QP
AD
-
-----
-
LS
A
LRF
F
L
CGGT
TIPKK
V
A
R
E
-----
C
QQ
R
G
I
K
---
LL
SV
YG
S
TE
S
SPHA
V
V
N
L
--
D
D
P
L
-P
R
FMH
-
T
D
G
Y
A
A
A
GVE
IK
V
VDD
ARK
T
LP
P
G
C
EGE
--
-
EA
S
---
R
G
P
N
V
F
-------
MG
YF
DE
P
EL
TA
R
A
L
DEE
GWY
Y
SGD
LC
R
M
DE
A
GY
IK
ITGR
KK
D
I
I
V
RGGEN
I
S
SR
E
V
E
D
IL
LQ
HPKI
H
DA
C
VV
AM
PD
E
R
L
GE
RS
C
AYVVL
K
A
PHH
S
LS
L
EE
V
--
V
A
F
F
S
RK
R
V
AK
Y
K
Y
P
EH
I
VVI
E
K
LPRT
V
SGKI
QKFL
LRK
DI
fig|869729.3.peg.1834
Escherichia coli UM146 (20-535/548)
LW
G
DAS
L
ADY
W
QQT
A
RAMP
DK
I
A
V
V
D
N
-
HG
A
T
----
Y
T
Y
S
A
L
D
HAAS
C
L
AN
WM
L
A
K
GI
E
S
GD
R
I
A
FQ
LP
GW
C
EF
T
V
IY
LAC
L
K
T
GAV
S
VP
L
LPSWRE
A
E
L
V
W
V
L
NK
C
QA
K
M
F-
--
--
F
A
P
T
LFK
Q
TR
PVDLILPL
Q
N
QLP
QL
Q
Q
I
V
G
---
VD
K
LA
--
PA
TS
S
L
S
LSQI
L
A
D
-------------------
N
T
P
--
L
TT
A
ITT
H
G
D
E
L
A
A
V
LFTSGT
E
G
L
PKGV
M
L
TH
N
N
I
L
ASERA
Y
C
A
R
L
NLT
WQ
------
DV
F
MMP
AP
L
GH
A
TG
FLHGVT
APF
LI
GA
R
S
VL
L
D
IF
----
TP
D
A
CLAL
L
E
Q
Q
R
C
T
CMLGA
T
PFV
Y
DL
LN
L
L
E
K
QP
AD
-
-----
-
LS
A
LRF
F
L
CGGT
TIPKK
V
A
R
E
-----
C
QQ
R
G
I
K
---
LL
SV
YG
S
TE
S
SPHA
V
V
N
L
--
D
D
P
L
-P
R
FMH
-
T
D
G
Y
A
A
A
GVE
IK
V
VDD
ARK
T
LP
P
G
C
EGE
--
-
EA
S
---
R
G
P
N
V
F
-------
MG
YF
DE
P
EL
TA
R
A
L
DEE
GWY
Y
SGD
LC
R
M
DE
A
GY
IK
ITGR
KK
D
I
I
V
RGGEN
I
S
SR
E
V
E
D
IL
LQ
HPKI
H
DA
C
VV
AM
PD
E
R
L
GE
RS
C
AYVVL
K
A
PHH
S
LS
L
EE
V
--
V
A
F
F
S
RK
R
V
AK
Y
K
Y
P
EH
I
VVI
E
K
LPRT
V
SGKI
QKFL
LRK
DI
fig|562.376.peg.2419
Escherichia coli WV_060327 (20-535/548)
LW
G
DAS
L
ADY
W
QQT
A
RAMP
DK
I
A
V
V
D
N
-
HG
A
T
----
Y
T
Y
S
A
L
D
HAAS
C
L
AN
WM
L
A
K
GI
E
S
GD
R
I
A
FQ
LP
GW
C
EF
T
V
IY
LAC
L
K
T
GAV
S
VP
L
LPSWRE
A
E
L
V
W
V
L
NK
C
QA
K
M
F-
--
--
F
A
P
T
LFK
Q
TR
PVDLILPL
Q
N
QLP
QL
Q
Q
I
V
G
---
VD
K
LA
--
PA
TS
S
L
S
LSQI
L
A
D
-------------------
N
T
P
--
L
TT
A
ITT
H
G
D
E
L
A
A
V
LFTSGT
E
G
L
PKGV
M
L
TH
N
N
I
L
ASERA
Y
C
A
R
L
NLT
WQ
------
DV
F
MMP
AP
L
GH
A
TG
FLHGVT
APF
LI
GA
R
S
VL
L
D
IF
----
TP
D
A
CLAL
L
E
Q
Q
R
C
T
CMLGA
T
PFV
Y
DL
LN
L
L
E
K
QP
AD
-
-----
-
LS
A
LRF
F
L
CGGT
TIPKK
V
A
R
E
-----
C
QQ
R
G
I
K
---
LL
SV
YG
S
TE
S
SPHA
V
V
N
L
--
D
D
P
L
-P
R
FMH
-
T
D
G
Y
A
A
A
GVE
IK
V
VDD
ARK
T
LP
P
G
C
EGE
--
-
EA
S
---
R
G
P
N
V
F
-------
MG
YF
DE
P
EL
TA
R
A
L
DEE
GWY
Y
SGD
LC
R
M
DE
A
GY
IK
ITGR
KK
D
I
I
V
RGGEN
I
S
SR
E
V
E
D
IL
LQ
HPKI
H
DA
C
VV
AM
PD
E
R
L
GE
RS
C
AYVVL
K
A
PHH
S
LS
L
EE
V
--
V
A
F
F
S
RK
R
V
AK
Y
K
Y
P
EH
I
VVI
E
K
LPRT
V
SGKI
QKFL
LRK
DI
fig|656417.3.peg.2203
Escherichia coli M605 (20-526/548)
LW
G
DAS
L
ADY
W
QQT
A
RAMP
DK
I
A
V
V
D
N
-
HG
A
T
----
Y
T
Y
S
A
L
D
HAAS
C
L
AN
WM
L
A
K
GI
E
S
GD
R
I
A
FQ
LP
GW
C
EF
T
V
IY
LAC
L
K
T
GAV
S
VP
L
LPSWRE
A
E
L
V
W
V
L
NK
C
QA
K
M
F-
--
--
F
A
P
T
LFK
Q
TR
PVDLILPL
Q
N
QLP
QL
Q
Q
I
V
G
---
VD
K
LA
--
PA
TS
S
L
S
LSQI
L
A
D
-------------------
N
T
P
--
L
TT
A
ITT
H
G
D
E
L
A
A
V
LFTSGT
E
G
L
PKGV
M
L
TH
N
N
I
L
ASERA
Y
C
A
R
L
NLT
WQ
------
DV
F
MMP
AP
L
GH
A
TG
FLHGVT
APF
LI
GA
R
S
VL
L
D
IF
----
TP
D
A
CLAL
L
E
Q
Q
R
C
T
CMLGA
T
PFV
Y
DL
LN
L
L
E
K
QP
AD
-
-----
-
LS
A
LRF
F
L
CGGT
TIPKK
V
A
R
E
-----
C
QQ
R
G
I
K
---
LL
SV
YG
S
TE
S
SPHA
V
V
N
L
--
D
D
P
L
-P
R
FMH
-
T
D
G
Y
A
A
A
GVE
IK
V
VDD
ARK
T
LP
P
G
C
EGE
--
-
EA
S
---
R
G
P
N
V
F
-------
MG
YF
DE
P
EL
TA
R
A
L
DEE
GWY
Y
SGD
LC
R
M
DE
A
GY
IK
ITGR
KK
D
I
I
V
RGGEN
I
S
SR
E
V
E
D
IL
LQ
HPKI
H
DA
C
VV
AM
PD
E
R
L
GE
RS
C
AYVVL
K
A
PHH
S
LS
L
EE
V
--
V
A
F
F
S
RK
R
V
AK
Y
K
Y
P
EH
I
VVI
E
K
LPRT
V
SGKI
fig|656379.3.peg.2174
Escherichia coli FVEC1302 (20-535/548)
LW
G
DAS
L
ADY
W
QQT
A
RAMP
DK
I
A
V
V
D
N
-
HG
AS
----
Y
T
Y
S
A
L
D
HAAS
C
L
AN
WM
L
A
K
GI
E
S
GD
R
I
A
FQ
LP
GW
C
EF
T
V
IY
LAC
L
KIGAV
S
VP
L
LPSWRE
A
E
L
V
W
V
L
NK
C
QA
K
M
F-
--
--
F
A
P
T
LFK
Q
TR
PVDLILPL
Q
N
QLP
QL
Q
Q
L
V
G
---
VD
K
LA
--
PA
TS
A
L
S
LSQI
IA
D
-------------------
N
T
P
--
L
TT
A
ITV
H
G
D
E
L
A
A
V
LFTSGT
E
G
L
PKGV
M
L
TH
N
N
I
L
ASERA
Y
C
A
R
L
NLT
WQ
------
DV
F
MMP
AP
L
GH
A
TG
FLHGVT
APF
LI
GA
R
S
VL
L
D
IF
----
TP
D
A
CLAL
L
E
Q
Q
R
C
T
CMLGA
T
PFV
Y
DL
LN
L
L
E
K
QP
AD
-
-----
-
LS
A
LRF
F
L
CGGT
TIPKK
V
A
R
E
-----
C
QQ
R
G
I
K
---
LL
SV
YG
S
TE
S
SPHA
V
V
N
L
--
D
D
P
L
-S
R
FMH
-
T
D
G
Y
A
A
A
GVE
IK
V
VDD
ARK
T
LP
P
G
C
EGE
--
-
EA
S
---
R
G
P
N
V
F
-------
MG
YF
DE
P
EL
TA
R
A
L
DEE
GWY
Y
SGD
LC
C
M
DE
A
GY
IK
ITGR
KK
D
I
I
V
RGGEN
I
S
SR
E
V
E
D
IL
LQ
HPKI
H
DA
C
VV
AM
PD
E
R
L
GE
RS
C
AYVVL
K
A
PHH
S
LS
L
EE
V
--
V
A
F
F
S
RK
R
V
AK
Y
K
Y
P
EH
I
VVI
E
K
LPRT
A
SGKI
QKFL
LRK
DI
fig|656380.3.peg.3138
Escherichia coli FVEC1412 (20-535/548)
LW
G
DAS
L
ADY
W
QQT
A
RAMP
DK
I
A
V
V
D
N
-
HG
AS
----
Y
T
Y
S
A
L
D
HAAS
C
L
AN
WM
L
A
K
GI
E
S
GD
R
I
A
FQ
LP
GW
C
EF
T
V
IY
LAC
L
KIGAV
S
VP
L
LPSWRE
A
E
L
V
W
V
L
NK
C
QA
K
M
F-
--
--
F
A
P
T
LFK
Q
TR
PVDLILPL
Q
N
QLP
QL
Q
Q
L
V
G
---
VD
K
LA
--
PA
TS
A
L
S
LSQI
IA
D
-------------------
N
T
P
--
L
TT
A
ITV
H
G
D
E
L
A
A
V
LFTSGT
E
G
L
PKGV
M
L
TH
N
N
I
L
ASERA
Y
C
A
R
L
NLT
WQ
------
DV
F
MMP
AP
L
GH
A
TG
FLHGVT
APF
LI
GA
R
S
VL
L
D
IF
----
TP
D
A
CLAL
L
E
Q
Q
R
C
T
CMLGA
T
PFV
Y
DL
LN
L
L
E
K
QP
AD
-
-----
-
LS
A
LRF
F
L
CGGT
TIPKK
V
A
R
E
-----
C
QQ
R
G
I
K
---
LL
SV
YG
S
TE
S
SPHA
V
V
N
L
--
D
D
P
L
-S
R
FMH
-
T
D
G
Y
A
A
A
GVE
IK
V
VDD
ARK
T
LP
P
G
C
EGE
--
-
EA
S
---
R
G
P
N
V
F
-------
MG
YF
DE
P
EL
TA
R
A
L
DEE
GWY
Y
SGD
LC
C
M
DE
A
GY
IK
ITGR
KK
D
I
I
V
RGGEN
I
S
SR
E
V
E
D
IL
LQ
HPKI
H
DA
C
VV
AM
PD
E
R
L
GE
RS
C
AYVVL
K
A
PHH
S
LS
L
EE
V
--
V
A
F
F
S
RK
R
V
AK
Y
K
Y
P
EH
I
VVI
E
K
LPRT
A
SGKI
QKFL
LRK
DI
fig|749549.3.peg.2522
Escherichia coli MS 198-1 (20-535/548)
LW
G
DAS
L
ADY
W
QQT
A
RAMP
DK
I
A
V
V
D
N
-
HG
AS
----
Y
T
Y
S
A
L
D
HAAS
C
L
AN
WM
L
A
K
GI
E
S
GD
R
I
A
FQ
LP
GW
C
EF
T
V
IY
LAC
L
KIGAV
S
VP
L
LPSWRE
A
E
L
V
W
V
L
NK
C
QA
K
M
F-
--
--
F
A
P
T
LFK
Q
TR
PVDLILPL
Q
N
QLP
QL
Q
Q
L
V
G
---
VD
K
LA
--
PA
TS
A
L
S
LSQI
IA
D
-------------------
N
T
P
--
L
TT
A
ITV
H
G
D
E
L
A
A
V
LFTSGT
E
G
L
PKGV
M
L
TH
N
N
I
L
ASERA
Y
C
A
R
L
NLT
WQ
------
DV
F
MMP
AP
L
GH
A
TG
FLHGVT
APF
LI
GA
R
S
VL
L
D
IF
----
TP
D
A
CLAL
L
E
Q
Q
R
C
T
CMLGA
T
PFV
Y
DL
LN
L
L
E
K
QP
AD
-
-----
-
LS
A
LRF
F
L
CGGT
TIPKK
V
A
R
E
-----
C
QQ
R
G
I
K
---
LL
SV
YG
S
TE
S
SPHA
V
V
N
L
--
D
D
P
L
-S
R
FMH
-
T
D
G
Y
A
A
A
GVE
IK
V
VDD
ARK
T
LP
P
G
C
EGE
--
-
EA
S
---
R
G
P
N
V
F
-------
MG
YF
DE
P
EL
TA
R
A
L
DEE
GWY
Y
SGD
LC
C
M
DE
A
GY
IK
ITGR
KK
D
I
I
V
RGGEN
I
S
SR
E
V
E
D
IL
LQ
HPKI
H
DA
C
VV
AM
PD
E
R
L
GE
RS
C
AYVVL
K
A
PHH
S
LS
L
EE
V
--
V
A
F
F
S
RK
R
V
AK
Y
K
Y
P
EH
I
VVI
E
K
LPRT
A
SGKI
QKFL
LRK
DI
fig|585056.7.peg.2177
Escherichia coli UMN026 (20-535/548)
LW
G
DAS
L
ADY
W
QQT
A
RAMP
DK
I
A
V
V
D
N
-
HG
AS
----
Y
T
Y
S
A
L
D
HAAS
C
L
AN
WM
L
A
K
GI
E
S
GD
R
I
A
FQ
LP
GW
C
EF
T
V
IY
LAC
L
KIGAV
S
VP
L
LPSWRE
A
E
L
V
W
V
L
NK
C
QA
K
M
F-
--
--
F
A
P
T
LFK
Q
TR
PVDLILPL
Q
N
QLP
QL
Q
Q
L
V
G
---
VD
K
LA
--
PA
TS
A
L
S
LSQI
IA
D
-------------------
N
T
P
--
L
TT
A
ITV
H
G
D
E
L
A
A
V
LFTSGT
E
G
L
PKGV
M
L
TH
N
N
I
L
ASERA
Y
C
A
R
L
NLT
WQ
------
DV
F
MMP
AP
L
GH
A
TG
FLHGVT
APF
LI
GA
R
S
VL
L
D
IF
----
TP
D
A
CLAL
L
E
Q
Q
R
C
T
CMLGA
T
PFV
Y
DL
LN
L
L
E
K
QP
AD
-
-----
-
LS
A
LRF
F
L
CGGT
TIPKK
V
A
R
E
-----
C
QQ
R
G
I
K
---
LL
SV
YG
S
TE
S
SPHA
V
V
N
L
--
D
D
P
L
-S
R
FMH
-
T
D
G
Y
A
A
A
GVE
IK
V
VDD
ARK
T
LP
P
G
C
EGE
--
-
EA
S
---
R
G
P
N
V
F
-------
MG
YF
DE
P
EL
TA
R
A
L
DEE
GWY
Y
SGD
LC
C
M
DE
A
GY
IK
ITGR
KK
D
I
I
V
RGGEN
I
S
SR
E
V
E
D
IL
LQ
HPKI
H
DA
C
VV
AM
PD
E
R
L
GE
RS
C
AYVVL
K
A
PHH
S
LS
L
EE
V
--
V
A
F
F
S
RK
R
V
AK
Y
K
Y
P
EH
I
VVI
E
K
LPRT
A
SGKI
QKFL
LRK
DI
fig|216592.3.peg.1942
Escherichia coli 042 (20-535/548)
LW
G
DAS
L
ADY
W
QQT
A
RAMP
DK
I
A
V
V
D
N
-
HG
AS
----
Y
T
Y
S
A
L
D
HAAS
C
L
AN
WM
L
A
K
GI
E
S
GD
R
I
A
FQ
LP
GW
C
EF
T
V
IY
LAC
L
KIGAV
S
VP
L
LPSWRE
A
E
L
V
W
V
L
NK
C
QA
K
M
F-
--
--
F
A
P
T
LFK
Q
TR
PVDLILPL
Q
N
QLP
QL
Q
Q
L
V
G
---
VD
K
LA
--
PA
TS
A
L
S
LSQI
IA
D
-------------------
N
T
P
--
L
TT
A
ITV
H
G
D
E
L
A
A
V
LFTSGT
E
G
L
PKGV
M
L
TH
N
N
I
L
ASERA
Y
C
A
R
L
NLT
WQ
------
DV
F
MMP
AP
L
GH
A
TG
FLHGVT
APF
LI
GA
R
S
VL
L
D
IF
----
TP
D
A
CLAL
L
E
Q
Q
R
C
T
CMLGA
T
PFV
Y
DL
LN
L
L
E
K
QP
AD
-
-----
-
LS
A
LRF
F
L
CGGT
TIPKK
V
A
R
E
-----
C
QQ
R
G
I
K
---
LL
SV
YG
S
TE
S
SPHA
V
V
N
L
--
D
D
P
L
-S
R
FMH
-
T
D
G
Y
A
A
A
GVE
IK
V
VDD
ARK
T
LP
P
G
C
EGE
--
-
EA
S
---
R
G
P
N
V
F
-------
MG
YF
DE
P
EL
TA
R
A
L
DEE
GWY
Y
SGD
LC
C
M
DE
A
GY
IK
ITGR
KK
D
I
I
V
RGGEN
I
S
SR
E
V
E
D
IL
LQ
HPKI
H
DA
C
VV
AM
PD
E
R
L
GE
RS
C
AYVVL
K
A
PHH
S
LS
L
EE
V
--
V
A
F
F
S
RK
R
V
AK
Y
K
Y
P
EH
I
VVI
E
K
LPRT
A
SGKI
QKFL
LRK
DI
fig|216592.1.peg.1236
Escherichia coli 042 (38-553/566)
LW
G
DAS
L
ADY
W
QQT
A
RAMP
DK
I
A
V
V
D
N
-
HG
AS
----
Y
T
Y
S
A
L
D
HAAS
C
L
AN
WM
L
A
K
GI
E
S
GD
R
I
A
FQ
LP
GW
C
EF
T
V
IY
LAC
L
KIGAV
S
VP
L
LPSWRE
A
E
L
V
W
V
L
NK
C
QA
K
M
F-
--
--
F
A
P
T
LFK
Q
TR
PVDLILPL
Q
N
QLP
QL
Q
Q
L
V
G
---
VD
K
LA
--
PA
TS
A
L
S
LSQI
IA
D
-------------------
N
T
P
--
L
TT
A
ITV
H
G
D
E
L
A
A
V
LFTSGT
E
G
L
PKGV
M
L
TH
N
N
I
L
ASERA
Y
C
A
R
L
NLT
WQ
------
DV
F
MMP
AP
L
GH
A
TG
FLHGVT
APF
LI
GA
R
S
VL
L
D
IF
----
TP
D
A
CLAL
L
E
Q
Q
R
C
T
CMLGA
T
PFV
Y
DL
LN
L
L
E
K
QP
AD
-
-----
-
LS
A
LRF
F
L
CGGT
TIPKK
V
A
R
E
-----
C
QQ
R
G
I
K
---
LL
SV
YG
S
TE
S
SPHA
V
V
N
L
--
D
D
P
L
-S
R
FMH
-
T
D
G
Y
A
A
A
GVE
IK
V
VDD
ARK
T
LP
P
G
C
EGE
--
-
EA
S
---
R
G
P
N
V
F
-------
MG
YF
DE
P
EL
TA
R
A
L
DEE
GWY
Y
SGD
LC
C
M
DE
A
GY
IK
ITGR
KK
D
I
I
V
RGGEN
I
S
SR
E
V
E
D
IL
LQ
HPKI
H
DA
C
VV
AM
PD
E
R
L
GE
RS
C
AYVVL
K
A
PHH
S
LS
L
EE
V
--
V
A
F
F
S
RK
R
V
AK
Y
K
Y
P
EH
I
VVI
E
K
LPRT
A
SGKI
QKFL
LRK
DI
fig|216593.1.peg.478
Escherichia coli E2348/69 (38-553/566)
LW
G
DAS
L
ADY
W
QQT
A
RAMP
DK
I
A
V
V
D
N
-
HG
A
T
----
Y
T
Y
S
A
L
D
HAAS
C
L
AN
WM
L
A
K
GI
E
S
GD
R
I
A
FQ
LP
GW
C
EF
T
V
IY
LAC
L
K
T
GAV
S
VP
L
LPSWRE
A
E
L
V
W
V
L
NK
C
QA
K
M
F-
--
--
F
A
P
T
LFK
Q
TR
PVDLILPL
Q
N
QLP
QL
Q
Q
I
V
G
---
VD
K
L
S
--
PA
TS
S
L
S
LSQI
L
A
D
-------------------
N
T
P
--
L
TT
A
ITT
H
G
D
E
L
A
A
V
LFTSGT
E
G
L
PKGV
M
L
TH
N
N
I
L
ASERA
Y
C
A
R
L
NLT
WQ
------
DV
F
MMP
AP
L
GH
A
TG
FLHGVT
APF
LI
GA
R
S
VL
L
D
IF
----
TP
D
A
CLAL
L
E
Q
Q
R
C
T
CMLGA
T
PFV
Y
DL
LN
L
L
E
K
QP
AD
-
-----
-
LS
A
LRF
F
L
CGGT
TIPKK
V
A
R
E
-----
C
QQ
R
G
I
K
---
LL
SV
YG
S
TE
S
SPHA
V
V
N
L
--
D
D
P
L
-P
R
FMH
-
T
D
G
Y
A
A
A
GVE
IK
V
VDD
ARK
T
LP
P
G
C
EGE
--
-
EA
S
---
R
G
P
N
V
F
-------
MG
YF
DE
P
EL
TA
R
A
L
DEE
GWY
Y
SGD
LC
R
M
DE
A
GY
IK
ITGR
KK
D
I
I
V
RGGEN
I
S
SR
E
V
E
D
IL
LQ
HPKI
H
DA
C
VV
AM
PD
E
R
L
GE
RS
C
AYVVL
K
A
PHH
S
LS
L
EE
V
--
V
A
F
F
S
RK
R
V
AK
Y
K
Y
P
EH
I
VVI
E
K
LPRT
V
SGKI
QKFL
LRK
DI
fig|574521.7.peg.1829
Escherichia coli O127:H6 str. E2348/69 (38-553/566)
LW
G
DAS
L
ADY
W
QQT
A
RAMP
DK
I
A
V
V
D
N
-
HG
A
T
----
Y
T
Y
S
A
L
D
HAAS
C
L
AN
WM
L
A
K
GI
E
S
GD
R
I
A
FQ
LP
GW
C
EF
T
V
IY
LAC
L
K
T
GAV
S
VP
L
LPSWRE
A
E
L
V
W
V
L
NK
C
QA
K
M
F-
--
--
F
A
P
T
LFK
Q
TR
PVDLILPL
Q
N
QLP
QL
Q
Q
I
V
G
---
VD
K
L
S
--
PA
TS
S
L
S
LSQI
L
A
D
-------------------
N
T
P
--
L
TT
A
ITT
H
G
D
E
L
A
A
V
LFTSGT
E
G
L
PKGV
M
L
TH
N
N
I
L
ASERA
Y
C
A
R
L
NLT
WQ
------
DV
F
MMP
AP
L
GH
A
TG
FLHGVT
APF
LI
GA
R
S
VL
L
D
IF
----
TP
D
A
CLAL
L
E
Q
Q
R
C
T
CMLGA
T
PFV
Y
DL
LN
L
L
E
K
QP
AD
-
-----
-
LS
A
LRF
F
L
CGGT
TIPKK
V
A
R
E
-----
C
QQ
R
G
I
K
---
LL
SV
YG
S
TE
S
SPHA
V
V
N
L
--
D
D
P
L
-P
R
FMH
-
T
D
G
Y
A
A
A
GVE
IK
V
VDD
ARK
T
LP
P
G
C
EGE
--
-
EA
S
---
R
G
P
N
V
F
-------
MG
YF
DE
P
EL
TA
R
A
L
DEE
GWY
Y
SGD
LC
R
M
DE
A
GY
IK
ITGR
KK
D
I
I
V
RGGEN
I
S
SR
E
V
E
D
IL
LQ
HPKI
H
DA
C
VV
AM
PD
E
R
L
GE
RS
C
AYVVL
K
A
PHH
S
LS
L
EE
V
--
V
A
F
F
S
RK
R
V
AK
Y
K
Y
P
EH
I
VVI
E
K
LPRT
V
SGKI
QKFL
LRK
DI
fig|595496.3.peg.1662
Escherichia coli BW2952 (38-553/566)
LW
G
DAS
L
ADY
W
QQT
A
RAMP
DK
I
A
V
V
D
N
-
HG
AS
----
Y
T
Y
S
A
L
D
HAAS
C
L
AN
WM
L
A
K
GI
E
S
GD
R
I
A
FQ
LP
GW
C
EF
T
V
IY
LAC
L
KIGAV
S
VP
L
LPSWRE
A
E
L
V
W
V
L
NK
C
QA
K
M
F-
--
--
F
A
P
T
LFK
Q
TR
PVDLILPL
Q
N
QLP
QL
Q
Q
I
V
G
---
VD
K
LA
--
PA
TS
S
L
S
LSQI
IA
D
-------------------
N
T
S
--
L
TT
A
ITT
H
G
D
E
L
A
A
V
LFTSGT
E
G
L
PKGV
M
L
TH
N
N
I
L
ASERA
Y
C
A
R
L
NLT
WQ
------
DV
F
MMP
AP
L
GH
A
TG
FLHGVT
APF
LI
GA
R
S
VL
L
D
IF
----
TP
D
A
CLAL
L
E
Q
Q
R
C
T
CMLGA
T
PFV
Y
DL
LN
V
L
E
K
QP
AD
-
-----
-
LS
A
LRF
F
L
CGGT
TIPKK
V
A
R
E
-----
C
QQ
R
G
I
K
---
LL
SV
YG
S
TE
S
SPHA
V
V
N
L
--
D
D
P
L
-S
R
FMH
-
T
D
G
Y
A
A
A
GVE
IK
V
VDD
ARK
T
LP
P
G
C
EGE
--
-
EA
S
---
R
G
P
N
V
F
-------
MG
YF
DE
P
EL
TA
R
A
L
DEE
GWY
Y
SGD
LC
R
M
DE
A
GY
IK
ITGR
KK
D
I
I
V
RGGEN
I
S
SR
E
V
E
D
IL
LQ
HPKI
H
DA
C
VV
AM
S
D
E
R
L
GE
RS
C
AYVVL
K
A
PHH
S
LS
L
EE
V
--
V
A
F
F
S
RK
R
V
AK
Y
K
Y
P
EH
I
VVI
E
K
LPRT
T
SGKI
QKFL
LRK
DI
fig|536056.3.peg.2052
Escherichia coli DH1 (20-535/548)
LW
G
DAS
L
ADY
W
QQT
A
RAMP
DK
I
A
V
V
D
N
-
HG
AS
----
Y
T
Y
S
A
L
D
HAAS
C
L
AN
WM
L
A
K
GI
E
S
GD
R
I
A
FQ
LP
GW
C
EF
T
V
IY
LAC
L
KIGAV
S
VP
L
LPSWRE
A
E
L
V
W
V
L
NK
C
QA
K
M
F-
--
--
F
A
P
T
LFK
Q
TR
PVDLILPL
Q
N
QLP
QL
Q
Q
I
V
G
---
VD
K
LA
--
PA
TS
S
L
S
LSQI
IA
D
-------------------
N
T
S
--
L
TT
A
ITT
H
G
D
E
L
A
A
V
LFTSGT
E
G
L
PKGV
M
L
TH
N
N
I
L
ASERA
Y
C
A
R
L
NLT
WQ
------
DV
F
MMP
AP
L
GH
A
TG
FLHGVT
APF
LI
GA
R
S
VL
L
D
IF
----
TP
D
A
CLAL
L
E
Q
Q
R
C
T
CMLGA
T
PFV
Y
DL
LN
V
L
E
K
QP
AD
-
-----
-
LS
A
LRF
F
L
CGGT
TIPKK
V
A
R
E
-----
C
QQ
R
G
I
K
---
LL
SV
YG
S
TE
S
SPHA
V
V
N
L
--
D
D
P
L
-S
R
FMH
-
T
D
G
Y
A
A
A
GVE
IK
V
VDD
ARK
T
LP
P
G
C
EGE
--
-
EA
S
---
R
G
P
N
V
F
-------
MG
YF
DE
P
EL
TA
R
A
L
DEE
GWY
Y
SGD
LC
R
M
DE
A
GY
IK
ITGR
KK
D
I
I
V
RGGEN
I
S
SR
E
V
E
D
IL
LQ
HPKI
H
DA
C
VV
AM
S
D
E
R
L
GE
RS
C
AYVVL
K
A
PHH
S
LS
L
EE
V
--
V
A
F
F
S
RK
R
V
AK
Y
K
Y
P
EH
I
VVI
E
K
LPRT
T
SGKI
QKFL
LRK
DI
fig|83333.1.peg.1685
Escherichia coli K12 (20-535/548)
LW
G
DAS
L
ADY
W
QQT
A
RAMP
DK
I
A
V
V
D
N
-
HG
AS
----
Y
T
Y
S
A
L
D
HAAS
C
L
AN
WM
L
A
K
GI
E
S
GD
R
I
A
FQ
LP
GW
C
EF
T
V
IY
LAC
L
KIGAV
S
VP
L
LPSWRE
A
E
L
V
W
V
L
NK
C
QA
K
M
F-
--
--
F
A
P
T
LFK
Q
TR
PVDLILPL
Q
N
QLP
QL
Q
Q
I
V
G
---
VD
K
LA
--
PA
TS
S
L
S
LSQI
IA
D
-------------------
N
T
S
--
L
TT
A
ITT
H
G
D
E
L
A
A
V
LFTSGT
E
G
L
PKGV
M
L
TH
N
N
I
L
ASERA
Y
C
A
R
L
NLT
WQ
------
DV
F
MMP
AP
L
GH
A
TG
FLHGVT
APF
LI
GA
R
S
VL
L
D
IF
----
TP
D
A
CLAL
L
E
Q
Q
R
C
T
CMLGA
T
PFV
Y
DL
LN
V
L
E
K
QP
AD
-
-----
-
LS
A
LRF
F
L
CGGT
TIPKK
V
A
R
E
-----
C
QQ
R
G
I
K
---
LL
SV
YG
S
TE
S
SPHA
V
V
N
L
--
D
D
P
L
-S
R
FMH
-
T
D
G
Y
A
A
A
GVE
IK
V
VDD
ARK
T
LP
P
G
C
EGE
--
-
EA
S
---
R
G
P
N
V
F
-------
MG
YF
DE
P
EL
TA
R
A
L
DEE
GWY
Y
SGD
LC
R
M
DE
A
GY
IK
ITGR
KK
D
I
I
V
RGGEN
I
S
SR
E
V
E
D
IL
LQ
HPKI
H
DA
C
VV
AM
S
D
E
R
L
GE
RS
C
AYVVL
K
A
PHH
S
LS
L
EE
V
--
V
A
F
F
S
RK
R
V
AK
Y
K
Y
P
EH
I
VVI
E
K
LPRT
T
SGKI
QKFL
LRK
DI
fig|749538.3.peg.4682
Escherichia coli MS 116-1 (20-535/548)
LW
G
DAS
L
ADY
W
QQT
A
RAMP
DK
I
A
V
V
D
N
-
HG
AS
----
Y
T
Y
S
A
L
D
HAAS
C
L
AN
WM
L
A
K
GI
E
S
GD
R
I
A
FQ
LP
GW
C
EF
T
V
IY
LAC
L
KIGAV
S
VP
L
LPSWRE
A
E
L
V
W
V
L
NK
C
QA
K
M
F-
--
--
F
A
P
T
LFK
Q
TR
PVDLILPL
Q
N
QLP
QL
Q
Q
I
V
G
---
VD
K
LA
--
PA
TS
S
L
S
LSQI
IA
D
-------------------
N
T
S
--
L
TT
A
ITT
H
G
D
E
L
A
A
V
LFTSGT
E
G
L
PKGV
M
L
TH
N
N
I
L
ASERA
Y
C
A
R
L
NLT
WQ
------
DV
F
MMP
AP
L
GH
A
TG
FLHGVT
APF
LI
GA
R
S
VL
L
D
IF
----
TP
D
A
CLAL
L
E
Q
Q
R
C
T
CMLGA
T
PFV
Y
DL
LN
V
L
E
K
QP
AD
-
-----
-
LS
A
LRF
F
L
CGGT
TIPKK
V
A
R
E
-----
C
QQ
R
G
I
K
---
LL
SV
YG
S
TE
S
SPHA
V
V
N
L
--
D
D
P
L
-S
R
FMH
-
T
D
G
Y
A
A
A
GVE
IK
V
VDD
ARK
T
LP
P
G
C
EGE
--
-
EA
S
---
R
G
P
N
V
F
-------
MG
YF
DE
P
EL
TA
R
A
L
DEE
GWY
Y
SGD
LC
R
M
DE
A
GY
IK
ITGR
KK
D
I
I
V
RGGEN
I
S
SR
E
V
E
D
IL
LQ
HPKI
H
DA
C
VV
AM
S
D
E
R
L
GE
RS
C
AYVVL
K
A
PHH
S
LS
L
EE
V
--
V
A
F
F
S
RK
R
V
AK
Y
K
Y
P
EH
I
VVI
E
K
LPRT
T
SGKI
QKFL
LRK
DI
fig|749548.3.peg.3581
Escherichia coli MS 196-1 (20-535/548)
LW
G
DAS
L
ADY
W
QQT
A
RAMP
DK
I
A
V
V
D
N
-
HG
AS
----
Y
T
Y
S
A
L
D
HAAS
C
L
AN
WM
L
A
K
GI
E
S
GD
R
I
A
FQ
LP
GW
C
EF
T
V
IY
LAC
L
KIGAV
S
VP
L
LPSWRE
A
E
L
V
W
V
L
NK
C
QA
K
M
F-
--
--
F
A
P
T
LFK
Q
TR
PVDLILPL
Q
N
QLP
QL
Q
Q
I
V
G
---
VD
K
LA
--
PA
TS
S
L
S
LSQI
IA
D
-------------------
N
T
S
--
L
TT
A
ITT
H
G
D
E
L
A
A
V
LFTSGT
E
G
L
PKGV
M
L
TH
N
N
I
L
ASERA
Y
C
A
R
L
NLT
WQ
------
DV
F
MMP
AP
L
GH
A
TG
FLHGVT
APF
LI
GA
R
S
VL
L
D
IF
----
TP
D
A
CLAL
L
E
Q
Q
R
C
T
CMLGA
T
PFV
Y
DL
LN
V
L
E
K
QP
AD
-
-----
-
LS
A
LRF
F
L
CGGT
TIPKK
V
A
R
E
-----
C
QQ
R
G
I
K
---
LL
SV
YG
S
TE
S
SPHA
V
V
N
L
--
D
D
P
L
-S
R
FMH
-
T
D
G
Y
A
A
A
GVE
IK
V
VDD
ARK
T
LP
P
G
C
EGE
--
-
EA
S
---
R
G
P
N
V
F
-------
MG
YF
DE
P
EL
TA
R
A
L
DEE
GWY
Y
SGD
LC
R
M
DE
A
GY
IK
ITGR
KK
D
I
I
V
RGGEN
I
S
SR
E
V
E
D
IL
LQ
HPKI
H
DA
C
VV
AM
S
D
E
R
L
GE
RS
C
AYVVL
K
A
PHH
S
LS
L
EE
V
--
V
A
F
F
S
RK
R
V
AK
Y
K
Y
P
EH
I
VVI
E
K
LPRT
T
SGKI
QKFL
LRK
DI
fig|316407.3.peg.1657
Escherichia coli W3110 (38-553/566)
LW
G
DAS
L
ADY
W
QQT
A
RAMP
DK
I
A
V
V
D
N
-
HG
AS
----
Y
T
Y
S
A
L
D
HAAS
C
L
AN
WM
L
A
K
GI
E
S
GD
R
I
A
FQ
LP
GW
C
EF
T
V
IY
LAC
L
KIGAV
S
VP
L
LPSWRE
A
E
L
V
W
V
L
NK
C
QA
K
M
F-
--
--
F
A
P
T
LFK
Q
TR
PVDLILPL
Q
N
QLP
QL
Q
Q
I
V
G
---
VD
K
LA
--
PA
TS
S
L
S
LSQI
IA
D
-------------------
N
T
S
--
L
TT
A
ITT
H
G
D
E
L
A
A
V
LFTSGT
E
G
L
PKGV
M
L
TH
N
N
I
L
ASERA
Y
C
A
R
L
NLT
WQ
------
DV
F
MMP
AP
L
GH
A
TG
FLHGVT
APF
LI
GA
R
S
VL
L
D
IF
----
TP
D
A
CLAL
L
E
Q
Q
R
C
T
CMLGA
T
PFV
Y
DL
LN
V
L
E
K
QP
AD
-
-----
-
LS
A
LRF
F
L
CGGT
TIPKK
V
A
R
E
-----
C
QQ
R
G
I
K
---
LL
SV
YG
S
TE
S
SPHA
V
V
N
L
--
D
D
P
L
-S
R
FMH
-
T
D
G
Y
A
A
A
GVE
IK
V
VDD
ARK
T
LP
P
G
C
EGE
--
-
EA
S
---
R
G
P
N
V
F
-------
MG
YF
DE
P
EL
TA
R
A
L
DEE
GWY
Y
SGD
LC
R
M
DE
A
GY
IK
ITGR
KK
D
I
I
V
RGGEN
I
S
SR
E
V
E
D
IL
LQ
HPKI
H
DA
C
VV
AM
S
D
E
R
L
GE
RS
C
AYVVL
K
A
PHH
S
LS
L
EE
V
--
V
A
F
F
S
RK
R
V
AK
Y
K
Y
P
EH
I
VVI
E
K
LPRT
T
SGKI
QKFL
LRK
DI
fig|316385.5.peg.1814
Escherichia coli str. K-12 substr. DH10B (38-553/566)
LW
G
DAS
L
ADY
W
QQT
A
RAMP
DK
I
A
V
V
D
N
-
HG
AS
----
Y
T
Y
S
A
L
D
HAAS
C
L
AN
WM
L
A
K
GI
E
S
GD
R
I
A
FQ
LP
GW
C
EF
T
V
IY
LAC
L
KIGAV
S
VP
L
LPSWRE
A
E
L
V
W
V
L
NK
C
QA
K
M
F-
--
--
F
A
P
T
LFK
Q
TR
PVDLILPL
Q
N
QLP
QL
Q
Q
I
V
G
---
VD
K
LA
--
PA
TS
S
L
S
LSQI
IA
D
-------------------
N
T
S
--
L
TT
A
ITT
H
G
D
E
L
A
A
V
LFTSGT
E
G
L
PKGV
M
L
TH
N
N
I
L
ASERA
Y
C
A
R
L
NLT
WQ
------
DV
F
MMP
AP
L
GH
A
TG
FLHGVT
APF
LI
GA
R
S
VL
L
D
IF
----
TP
D
A
CLAL
L
E
Q
Q
R
C
T
CMLGA
T
PFV
Y
DL
LN
V
L
E
K
QP
AD
-
-----
-
LS
A
LRF
F
L
CGGT
TIPKK
V
A
R
E
-----
C
QQ
R
G
I
K
---
LL
SV
YG
S
TE
S
SPHA
V
V
N
L
--
D
D
P
L
-S
R
FMH
-
T
D
G
Y
A
A
A
GVE
IK
V
VDD
ARK
T
LP
P
G
C
EGE
--
-
EA
S
---
R
G
P
N
V
F
-------
MG
YF
DE
P
EL
TA
R
A
L
DEE
GWY
Y
SGD
LC
R
M
DE
A
GY
IK
ITGR
KK
D
I
I
V
RGGEN
I
S
SR
E
V
E
D
IL
LQ
HPKI
H
DA
C
VV
AM
S
D
E
R
L
GE
RS
C
AYVVL
K
A
PHH
S
LS
L
EE
V
--
V
A
F
F
S
RK
R
V
AK
Y
K
Y
P
EH
I
VVI
E
K
LPRT
T
SGKI
QKFL
LRK
DI
fig|316385.7.peg.1860
Escherichia coli str. K-12 substr. DH10B (38-553/566)
LW
G
DAS
L
ADY
W
QQT
A
RAMP
DK
I
A
V
V
D
N
-
HG
AS
----
Y
T
Y
S
A
L
D
HAAS
C
L
AN
WM
L
A
K
GI
E
S
GD
R
I
A
FQ
LP
GW
C
EF
T
V
IY
LAC
L
KIGAV
S
VP
L
LPSWRE
A
E
L
V
W
V
L
NK
C
QA
K
M
F-
--
--
F
A
P
T
LFK
Q
TR
PVDLILPL
Q
N
QLP
QL
Q
Q
I
V
G
---
VD
K
LA
--
PA
TS
S
L
S
LSQI
IA
D
-------------------
N
T
S
--
L
TT
A
ITT
H
G
D
E
L
A
A
V
LFTSGT
E
G
L
PKGV
M
L
TH
N
N
I
L
ASERA
Y
C
A
R
L
NLT
WQ
------
DV
F
MMP
AP
L
GH
A
TG
FLHGVT
APF
LI
GA
R
S
VL
L
D
IF
----
TP
D
A
CLAL
L
E
Q
Q
R
C
T
CMLGA
T
PFV
Y
DL
LN
V
L
E
K
QP
AD
-
-----
-
LS
A
LRF
F
L
CGGT
TIPKK
V
A
R
E
-----
C
QQ
R
G
I
K
---
LL
SV
YG
S
TE
S
SPHA
V
V
N
L
--
D
D
P
L
-S
R
FMH
-
T
D
G
Y
A
A
A
GVE
IK
V
VDD
ARK
T
LP
P
G
C
EGE
--
-
EA
S
---
R
G
P
N
V
F
-------
MG
YF
DE
P
EL
TA
R
A
L
DEE
GWY
Y
SGD
LC
R
M
DE
A
GY
IK
ITGR
KK
D
I
I
V
RGGEN
I
S
SR
E
V
E
D
IL
LQ
HPKI
H
DA
C
VV
AM
S
D
E
R
L
GE
RS
C
AYVVL
K
A
PHH
S
LS
L
EE
V
--
V
A
F
F
S
RK
R
V
AK
Y
K
Y
P
EH
I
VVI
E
K
LPRT
T
SGKI
QKFL
LRK
DI
fig|511145.12.peg.1772
Escherichia coli str. K-12 substr. MG1655 (20-535/548)
LW
G
DAS
L
ADY
W
QQT
A
RAMP
DK
I
A
V
V
D
N
-
HG
AS
----
Y
T
Y
S
A
L
D
HAAS
C
L
AN
WM
L
A
K
GI
E
S
GD
R
I
A
FQ
LP
GW
C
EF
T
V
IY
LAC
L
KIGAV
S
VP
L
LPSWRE
A
E
L
V
W
V
L
NK
C
QA
K
M
F-
--
--
F
A
P
T
LFK
Q
TR
PVDLILPL
Q
N
QLP
QL
Q
Q
I
V
G
---
VD
K
LA
--
PA
TS
S
L
S
LSQI
IA
D
-------------------
N
T
S
--
L
TT
A
ITT
H
G
D
E
L
A
A
V
LFTSGT
E
G
L
PKGV
M
L
TH
N
N
I
L
ASERA
Y
C
A
R
L
NLT
WQ
------
DV
F
MMP
AP
L
GH
A
TG
FLHGVT
APF
LI
GA
R
S
VL
L
D
IF
----
TP
D
A
CLAL
L
E
Q
Q
R
C
T
CMLGA
T
PFV
Y
DL
LN
V
L
E
K
QP
AD
-
-----
-
LS
A
LRF
F
L
CGGT
TIPKK
V
A
R
E
-----
C
QQ
R
G
I
K
---
LL
SV
YG
S
TE
S
SPHA
V
V
N
L
--
D
D
P
L
-S
R
FMH
-
T
D
G
Y
A
A
A
GVE
IK
V
VDD
ARK
T
LP
P
G
C
EGE
--
-
EA
S
---
R
G
P
N
V
F
-------
MG
YF
DE
P
EL
TA
R
A
L
DEE
GWY
Y
SGD
LC
R
M
DE
A
GY
IK
ITGR
KK
D
I
I
V
RGGEN
I
S
SR
E
V
E
D
IL
LQ
HPKI
H
DA
C
VV
AM
S
D
E
R
L
GE
RS
C
AYVVL
K
A
PHH
S
LS
L
EE
V
--
V
A
F
F
S
RK
R
V
AK
Y
K
Y
P
EH
I
VVI
E
K
LPRT
T
SGKI
QKFL
LRK
DI
fig|511145.6.peg.1757
Escherichia coli str. K-12 substr. MG1655 (38-553/566)
LW
G
DAS
L
ADY
W
QQT
A
RAMP
DK
I
A
V
V
D
N
-
HG
AS
----
Y
T
Y
S
A
L
D
HAAS
C
L
AN
WM
L
A
K
GI
E
S
GD
R
I
A
FQ
LP
GW
C
EF
T
V
IY
LAC
L
KIGAV
S
VP
L
LPSWRE
A
E
L
V
W
V
L
NK
C
QA
K
M
F-
--
--
F
A
P
T
LFK
Q
TR
PVDLILPL
Q
N
QLP
QL
Q
Q
I
V
G
---
VD
K
LA
--
PA
TS
S
L
S
LSQI
IA
D
-------------------
N
T
S
--
L
TT
A
ITT
H
G
D
E
L
A
A
V
LFTSGT
E
G
L
PKGV
M
L
TH
N
N
I
L
ASERA
Y
C
A
R
L
NLT
WQ
------
DV
F
MMP
AP
L
GH
A
TG
FLHGVT
APF
LI
GA
R
S
VL
L
D
IF
----
TP
D
A
CLAL
L
E
Q
Q
R
C
T
CMLGA
T
PFV
Y
DL
LN
V
L
E
K
QP
AD
-
-----
-
LS
A
LRF
F
L
CGGT
TIPKK
V
A
R
E
-----
C
QQ
R
G
I
K
---
LL
SV
YG
S
TE
S
SPHA
V
V
N
L
--
D
D
P
L
-S
R
FMH
-
T
D
G
Y
A
A
A
GVE
IK
V
VDD
ARK
T
LP
P
G
C
EGE
--
-
EA
S
---
R
G
P
N
V
F
-------
MG
YF
DE
P
EL
TA
R
A
L
DEE
GWY
Y
SGD
LC
R
M
DE
A
GY
IK
ITGR
KK
D
I
I
V
RGGEN
I
S
SR
E
V
E
D
IL
LQ
HPKI
H
DA
C
VV
AM
S
D
E
R
L
GE
RS
C
AYVVL
K
A
PHH
S
LS
L
EE
V
--
V
A
F
F
S
RK
R
V
AK
Y
K
Y
P
EH
I
VVI
E
K
LPRT
T
SGKI
QKFL
LRK
DI
fig|364106.7.peg.1934
Escherichia coli UTI89 (20-535/548)
LW
G
DAS
L
ADY
W
QQT
A
RAMP
DK
I
A
V
V
D
N
-
HG
A
T
----
Y
T
Y
S
A
L
D
HAAS
C
L
AN
WM
L
A
K
GI
E
S
GD
R
I
A
FQ
LP
GW
C
EF
T
V
IY
LAC
L
K
T
GAV
S
VP
L
LPSWRE
A
E
L
V
W
V
L
NK
C
QA
K
M
F-
--
--
F
A
P
T
LFK
Q
TR
PVDLILPL
Q
N
QLP
QL
Q
Q
I
V
G
---
VD
K
LA
--
PA
TS
S
L
S
LSQI
L
A
D
-------------------
N
T
P
--
L
TT
A
ITT
H
G
D
E
L
A
A
V
LFTSGT
E
G
L
PKGV
M
L
TH
N
N
I
L
ASERA
Y
C
A
R
L
NLT
WQ
------
DV
F
MMP
AP
L
GH
A
TG
FLHGVT
APF
LI
GA
R
S
VL
L
D
IF
----
TP
D
A
CLAL
L
E
Q
Q
R
C
T
CMLGA
T
PFV
Y
DL
LN
L
L
E
K
QP
AD
-
-----
-
LS
A
LRF
F
L
CGGT
TIPKK
V
A
R
E
-----
C
QQ
R
G
I
K
---
LL
SV
YG
S
TE
S
SPHA
V
V
N
L
--
D
D
P
L
-P
R
FMH
-
T
D
G
Y
A
A
A
GVE
IK
V
VDD
ARK
T
LP
P
G
C
EGE
--
-
EA
S
---
R
G
P
N
V
F
-------
MG
YF
DE
P
EL
TA
R
A
L
DEE
GWY
Y
SGD
LC
R
M
DE
A
GY
IK
ITGR
NK
D
I
I
V
RGGEN
I
S
SR
E
V
E
D
IL
LQ
HPKI
H
DA
C
VV
AM
PD
E
R
L
GE
RS
C
AYVVL
K
A
PHH
S
LS
L
EE
V
--
V
A
F
F
S
RK
R
V
AK
Y
K
Y
P
EH
I
VVI
E
K
LPRT
V
SGKI
QKFL
LRK
DI
fig|364106.8.peg.1937
Escherichia coli UTI89 (20-535/548)
LW
G
DAS
L
ADY
W
QQT
A
RAMP
DK
I
A
V
V
D
N
-
HG
A
T
----
Y
T
Y
S
A
L
D
HAAS
C
L
AN
WM
L
A
K
GI
E
S
GD
R
I
A
FQ
LP
GW
C
EF
T
V
IY
LAC
L
K
T
GAV
S
VP
L
LPSWRE
A
E
L
V
W
V
L
NK
C
QA
K
M
F-
--
--
F
A
P
T
LFK
Q
TR
PVDLILPL
Q
N
QLP
QL
Q
Q
I
V
G
---
VD
K
LA
--
PA
TS
S
L
S
LSQI
L
A
D
-------------------
N
T
P
--
L
TT
A
ITT
H
G
D
E
L
A
A
V
LFTSGT
E
G
L
PKGV
M
L
TH
N
N
I
L
ASERA
Y
C
A
R
L
NLT
WQ
------
DV
F
MMP
AP
L
GH
A
TG
FLHGVT
APF
LI
GA
R
S
VL
L
D
IF
----
TP
D
A
CLAL
L
E
Q
Q
R
C
T
CMLGA
T
PFV
Y
DL
LN
L
L
E
K
QP
AD
-
-----
-
LS
A
LRF
F
L
CGGT
TIPKK
V
A
R
E
-----
C
QQ
R
G
I
K
---
LL
SV
YG
S
TE
S
SPHA
V
V
N
L
--
D
D
P
L
-P
R
FMH
-
T
D
G
Y
A
A
A
GVE
IK
V
VDD
ARK
T
LP
P
G
C
EGE
--
-
EA
S
---
R
G
P
N
V
F
-------
MG
YF
DE
P
EL
TA
R
A
L
DEE
GWY
Y
SGD
LC
R
M
DE
A
GY
IK
ITGR
NK
D
I
I
V
RGGEN
I
S
SR
E
V
E
D
IL
LQ
HPKI
H
DA
C
VV
AM
PD
E
R
L
GE
RS
C
AYVVL
K
A
PHH
S
LS
L
EE
V
--
V
A
F
F
S
RK
R
V
AK
Y
K
Y
P
EH
I
VVI
E
K
LPRT
V
SGKI
QKFL
LRK
DI
fig|749527.3.peg.3506
Escherichia coli MS 21-1 (20-535/546)
LW
G
DAS
L
ADY
W
QQT
A
RAMP
DK
I
A
V
V
D
N
-
HG
A
T
----
Y
T
Y
S
A
L
D
HAAS
C
L
AN
WM
L
A
K
GI
E
S
GD
R
I
A
FQ
LP
GW
C
EF
T
V
IY
LAC
L
K
T
GAV
S
VP
L
LPSWRE
A
E
L
V
W
V
L
NK
C
QA
K
M
F-
--
--
F
A
P
T
LFK
Q
TR
PVDLILPL
Q
N
QLP
QL
Q
Q
I
V
G
---
VD
K
LA
--
PA
TS
S
L
S
LSQI
IA
D
-------------------
N
T
P
--
L
TT
A
ITV
H
G
D
E
L
A
A
V
LFTSGT
E
G
L
PKGV
M
L
TH
N
N
I
L
ASERA
Y
C
A
R
L
NLT
WQ
------
DV
F
MMP
AP
L
GH
A
TG
FLHGVT
APF
LI
GA
R
S
VL
L
D
IF
----
TP
A
A
CLAL
L
E
Q
Q
R
C
T
CMLGA
T
PFV
Y
DL
LN
L
L
E
K
QP
AD
-
-----
-
LS
A
LRF
F
L
CGGT
TIPKK
V
A
R
E
-----
C
QQ
R
G
I
K
---
LL
SV
YG
S
TE
S
SPHA
V
V
N
L
--
D
D
P
L
-S
R
FMH
-
T
D
G
Y
A
A
A
GVE
IK
V
VDD
ARK
S
LP
P
G
C
EGE
--
-
EA
S
---
R
G
P
N
V
F
-------
MG
YF
DE
P
EL
TA
R
A
L
DEE
GWY
Y
SGD
LC
R
M
DE
A
GY
IK
ITGR
KK
D
I
I
V
RGGEN
I
S
SR
E
V
E
D
IL
LQ
HPKI
H
DA
C
VV
AM
PD
E
R
L
GE
RS
C
AYVVL
K
A
PHH
S
LS
L
E
D
V
--
V
A
F
F
S
RK
R
V
AK
Y
K
Y
P
EH
I
VVI
E
K
LPRT
A
SGKI
QKFL
LRK
DI
fig|439855.10.peg.1653
Escherichia coli SMS-3-5 (20-535/546)
LW
G
DAS
L
ADY
W
QQT
A
RAMP
DK
I
A
V
V
D
N
-
HG
AS
----
Y
T
Y
S
A
L
D
HAAS
C
L
AN
WM
L
T
K
GI
E
S
GD
R
I
A
FQ
LP
GW
C
EF
T
V
IY
LAC
L
KIGAV
S
VP
L
LPSWRE
A
E
L
V
W
V
L
NK
C
QA
K
M
F-
--
--
F
A
P
T
LFK
Q
TR
PVDLILPL
Q
N
QLP
QL
Q
Q
I
V
G
---
VD
K
LA
--
PA
TS
S
L
S
LSQI
L
A
D
-------------------
N
T
P
--
L
TT
A
ITT
H
G
D
E
L
A
A
V
LFTSGT
E
G
L
PKGV
M
L
TH
N
N
I
L
ASERA
Y
C
A
R
L
NLT
WQ
------
DV
F
MMP
AP
L
GH
A
TG
FLHGVT
APF
LI
GA
R
S
VL
L
D
IF
----
TP
A
A
CLAL
L
E
Q
Q
R
C
T
CMLGA
T
PFV
Y
DL
LN
L
L
E
K
QP
AD
-
-----
-
LS
A
LRF
F
L
CGGT
TIPKK
V
A
R
E
-----
C
QQ
R
G
I
K
---
LL
SV
YG
S
TE
S
SPHA
V
V
N
L
--
D
D
P
L
-S
R
FMH
-
T
D
G
Y
A
A
A
GVE
IK
V
VD
G
ARK
T
LP
P
G
C
EGE
--
-
EA
S
---
R
G
P
N
V
F
-------
MG
YF
DE
P
EL
TA
H
A
L
DEE
GWY
Y
SGD
LC
R
M
DE
A
GY
IK
ITGR
KK
D
I
I
V
RGGEN
I
S
SR
E
V
E
D
IL
LQ
HPKI
H
DA
C
VV
AM
PD
E
R
L
GE
RS
C
AYVVL
K
A
PHH
S
LS
L
E
D
V
--
V
A
F
F
S
RK
R
V
AK
Y
K
Y
P
EH
I
VVI
E
K
LPRT
A
SGKI
QKFL
LRK
DI
fig|585034.4.peg.1737
Escherichia coli IAI1 (20-535/548)
LW
G
DAS
L
ADY
W
QQT
A
RAMP
DK
I
A
V
V
D
N
-
HG
AS
----
Y
T
Y
S
A
L
D
HAAS
C
L
AN
WM
L
A
K
GI
E
S
GD
R
I
A
FQ
LP
GW
C
EF
T
V
IY
LAC
L
KIGAV
S
VP
L
LPSWRE
A
E
L
V
W
V
L
NK
C
QA
K
M
F-
--
--
F
A
P
T
LFK
Q
TR
PVDLILPL
Q
N
QLP
QL
Q
Q
I
V
G
---
VD
K
LA
--
PA
TS
S
L
S
LSQI
IA
D
-------------------
N
T
S
--
L
TT
A
ITT
H
G
D
E
L
A
A
V
LFTSGT
E
G
L
PKGV
M
L
TH
N
N
I
L
ASERA
Y
C
V
R
L
NLT
WQ
------
DV
F
MMP
AP
L
GH
A
TG
FLHGVT
APF
LI
GA
R
S
VL
L
D
IF
----
TP
D
A
CLAL
L
E
Q
Q
R
C
T
CMLGA
T
PFV
Y
DL
LN
L
L
E
K
QP
AD
-
-----
-
LS
A
LRF
F
L
CGGT
TIPKK
V
A
R
E
-----
C
QQ
R
G
I
K
---
LL
SV
YG
S
TE
S
SPHA
V
V
N
L
--
D
D
P
L
-S
R
FMH
-
T
D
G
Y
A
A
A
GVE
IK
V
VDD
ARK
T
LP
P
G
C
EGE
--
-
EA
S
---
R
G
P
N
V
F
-------
MG
YF
DE
P
EL
TA
R
A
L
DEE
GWY
Y
SGD
LC
R
M
DE
A
GY
IK
ITGR
KK
D
I
I
V
RGGEN
I
S
SR
E
V
E
D
IL
LQ
HPKI
H
DA
C
VV
AM
PD
E
R
L
GE
RS
C
AYVVL
K
A
PHH
S
LS
L
EE
V
--
V
A
F
F
S
RK
R
V
AK
Y
K
Y
P
EH
I
VVI
E
K
LPRT
A
SGKI
QKFL
LRK
DI
fig|585034.5.peg.1732
Escherichia coli IAI1 (20-535/548)
LW
G
DAS
L
ADY
W
QQT
A
RAMP
DK
I
A
V
V
D
N
-
HG
AS
----
Y
T
Y
S
A
L
D
HAAS
C
L
AN
WM
L
A
K
GI
E
S
GD
R
I
A
FQ
LP
GW
C
EF
T
V
IY
LAC
L
KIGAV
S
VP
L
LPSWRE
A
E
L
V
W
V
L
NK
C
QA
K
M
F-
--
--
F
A
P
T
LFK
Q
TR
PVDLILPL
Q
N
QLP
QL
Q
Q
I
V
G
---
VD
K
LA
--
PA
TS
S
L
S
LSQI
IA
D
-------------------
N
T
S
--
L
TT
A
ITT
H
G
D
E
L
A
A
V
LFTSGT
E
G
L
PKGV
M
L
TH
N
N
I
L
ASERA
Y
C
V
R
L
NLT
WQ
------
DV
F
MMP
AP
L
GH
A
TG
FLHGVT
APF
LI
GA
R
S
VL
L
D
IF
----
TP
D
A
CLAL
L
E
Q
Q
R
C
T
CMLGA
T
PFV
Y
DL
LN
L
L
E
K
QP
AD
-
-----
-
LS
A
LRF
F
L
CGGT
TIPKK
V
A
R
E
-----
C
QQ
R
G
I
K
---
LL
SV
YG
S
TE
S
SPHA
V
V
N
L
--
D
D
P
L
-S
R
FMH
-
T
D
G
Y
A
A
A
GVE
IK
V
VDD
ARK
T
LP
P
G
C
EGE
--
-
EA
S
---
R
G
P
N
V
F
-------
MG
YF
DE
P
EL
TA
R
A
L
DEE
GWY
Y
SGD
LC
R
M
DE
A
GY
IK
ITGR
KK
D
I
I
V
RGGEN
I
S
SR
E
V
E
D
IL
LQ
HPKI
H
DA
C
VV
AM
PD
E
R
L
GE
RS
C
AYVVL
K
A
PHH
S
LS
L
EE
V
--
V
A
F
F
S
RK
R
V
AK
Y
K
Y
P
EH
I
VVI
E
K
LPRT
A
SGKI
QKFL
LRK
DI
fig|656393.3.peg.2498
Escherichia coli H299 (20-535/548)
LW
G
DAS
L
ADY
W
QQT
A
RAMP
DK
I
A
V
V
D
N
-
HG
A
T
----
Y
T
Y
S
A
L
D
HAAS
C
L
AN
WM
L
A
K
GI
E
S
GD
R
I
A
FQ
LP
GW
C
EF
T
V
IY
LAC
L
K
T
GAV
S
VP
L
LPSWRE
A
E
L
V
W
V
L
NK
C
QA
K
M
F-
--
--
F
A
P
T
LFK
Q
TR
PVDLILPL
Q
N
QLP
QL
Q
Q
I
V
G
---
VD
K
LA
--
PA
TS
A
L
S
LSQI
IA
D
-------------------
N
T
P
--
L
TT
A
ITV
H
G
D
E
L
A
A
V
LFTSGT
E
G
L
PKGV
M
L
TH
N
N
I
L
ASERA
Y
C
A
R
L
NLT
WQ
------
DV
F
MMP
AP
L
GH
A
TG
FLHGVT
APF
LI
GA
R
S
VL
L
D
IF
----
TP
A
A
CLAL
L
E
Q
Q
R
C
T
CMLGA
T
PFV
Y
DL
LN
L
L
E
K
QP
AD
-
-----
-
LS
A
LRF
F
L
CGGT
TIPKK
V
A
R
E
-----
C
QQ
R
G
I
K
---
LL
SV
YG
S
TE
S
SPHA
V
V
N
L
--
D
D
P
L
-S
R
FIH
-
T
D
G
Y
A
A
A
GVE
IK
V
VDD
ARK
T
LP
P
G
C
EGE
--
-
EA
S
---
R
G
P
N
V
F
-------
MG
YF
DE
P
EL
TA
R
A
L
DEE
GWY
Y
SGD
LC
R
M
DE
A
GY
IK
ITGR
KK
D
I
I
V
RGGEN
I
S
SR
E
V
E
D
IL
LQ
HPKI
H
DA
C
VV
AM
PD
E
R
L
GE
RS
C
AYVVL
K
A
PHH
S
LS
L
E
D
V
--
V
A
F
F
S
RK
R
V
AK
Y
K
Y
P
EH
I
VVI
E
K
LPRT
A
SGKI
QKFL
LRK
DI
fig|358709.5.peg.3200
Escherichia coli 101-1 (38-553/566)
LW
G
DAS
L
ADY
W
QQT
A
RAMP
DK
I
A
V
V
D
N
-
HG
A
T
----
Y
T
Y
S
A
L
D
HAAS
C
L
AN
WM
L
A
K
GI
E
S
GD
R
I
A
FQ
LP
GW
C
EF
T
V
IY
LAC
L
KIGAV
S
VP
L
LPSWRE
A
E
L
V
W
V
L
NK
C
QA
K
M
F-
--
--
F
A
P
T
LFK
Q
TR
PVDLILPL
Q
N
QLP
QL
Q
Q
I
V
G
---
VD
K
LA
--
PA
TS
S
L
S
LSQI
IA
D
-------------------
N
I
P
--
L
TT
A
ITT
H
G
D
E
L
A
A
V
LFTSGT
E
G
L
PKGV
M
L
TH
N
N
I
L
ASERA
Y
C
A
R
L
NLT
W
L
------
DV
F
MMP
AP
L
GH
A
TG
FLHGVT
APF
LI
GA
R
S
VL
L
D
IF
----
TP
D
A
CLAL
L
E
Q
Q
R
C
T
CMLGA
T
PFV
Y
DL
LN
L
L
E
K
QP
AD
-
-----
-
LS
A
LRF
F
L
CGGT
TIPKK
V
A
R
E
-----
C
QQ
L
G
I
K
---
LL
SV
YG
S
TE
S
SPHA
V
V
N
L
--
D
D
P
L
-S
R
FMH
-
T
D
G
Y
A
A
A
GVE
IK
V
V
N
D
ARK
T
LP
P
G
C
EGE
--
-
EA
S
---
R
G
P
N
V
F
-------
MG
YF
DE
P
EL
TA
R
A
L
DEE
GWY
Y
SGD
LC
R
M
DE
A
GY
IK
ITGR
KK
D
I
I
V
RGGEN
I
S
SR
E
V
E
D
IL
LQ
HPKI
H
DA
C
VV
AM
PD
E
R
L
GE
RS
C
AYVVL
K
A
PHH
S
LS
L
EE
V
--
V
A
F
F
S
RK
R
V
AK
Y
K
Y
P
EH
I
VVI
E
K
LPRT
A
SGKI
QKFL
LRK
DI
fig|413997.3.peg.1747
Escherichia coli B str. REL606 (38-553/566)
LW
G
DAS
L
ADY
W
QQT
A
RAMP
DK
I
A
V
V
D
N
-
HG
A
T
----
Y
T
Y
S
A
L
D
HAAS
C
L
AN
WM
L
A
K
GI
E
S
GD
R
I
A
FQ
LP
GW
C
EF
T
V
IY
LAC
L
KIGAV
S
VP
L
LPSWRE
A
E
L
V
W
V
L
NK
C
QA
K
M
F-
--
--
F
A
P
T
LFK
Q
TR
PVDLILPL
Q
N
QLP
QL
Q
Q
I
V
G
---
VD
K
LA
--
PA
TS
S
L
S
LSQI
IA
D
-------------------
N
I
P
--
L
TT
A
ITT
H
G
D
E
L
A
A
V
LFTSGT
E
G
L
PKGV
M
L
TH
N
N
I
L
ASERA
Y
C
A
R
L
NLT
W
L
------
DV
F
MMP
AP
L
GH
A
TG
FLHGVT
APF
LI
GA
R
S
VL
L
D
IF
----
TP
D
A
CLAL
L
E
Q
Q
R
C
T
CMLGA
T
PFV
Y
DL
LN
L
L
E
K
QP
AD
-
-----
-
LS
A
LRF
F
L
CGGT
TIPKK
V
A
R
E
-----
C
QQ
L
G
I
K
---
LL
SV
YG
S
TE
S
SPHA
V
V
N
L
--
D
D
P
L
-S
R
FMH
-
T
D
G
Y
A
A
A
GVE
IK
V
V
N
D
ARK
T
LP
P
G
C
EGE
--
-
EA
S
---
R
G
P
N
V
F
-------
MG
YF
DE
P
EL
TA
R
A
L
DEE
GWY
Y
SGD
LC
R
M
DE
A
GY
IK
ITGR
KK
D
I
I
V
RGGEN
I
S
SR
E
V
E
D
IL
LQ
HPKI
H
DA
C
VV
AM
PD
E
R
L
GE
RS
C
AYVVL
K
A
PHH
S
LS
L
EE
V
--
V
A
F
F
S
RK
R
V
AK
Y
K
Y
P
EH
I
VVI
E
K
LPRT
A
SGKI
QKFL
LRK
DI
fig|511693.5.peg.1775
Escherichia coli BL21 (38-553/566)
LW
G
DAS
L
ADY
W
QQT
A
RAMP
DK
I
A
V
V
D
N
-
HG
A
T
----
Y
T
Y
S
A
L
D
HAAS
C
L
AN
WM
L
A
K
GI
E
S
GD
R
I
A
FQ
LP
GW
C
EF
T
V
IY
LAC
L
KIGAV
S
VP
L
LPSWRE
A
E
L
V
W
V
L
NK
C
QA
K
M
F-
--
--
F
A
P
T
LFK
Q
TR
PVDLILPL
Q
N
QLP
QL
Q
Q
I
V
G
---
VD
K
LA
--
PA
TS
S
L
S
LSQI
IA
D
-------------------
N
I
P
--
L
TT
A
ITT
H
G
D
E
L
A
A
V
LFTSGT
E
G
L
PKGV
M
L
TH
N
N
I
L
ASERA
Y
C
A
R
L
NLT
W
L
------
DV
F
MMP
AP
L
GH
A
TG
FLHGVT
APF
LI
GA
R
S
VL
L
D
IF
----
TP
D
A
CLAL
L
E
Q
Q
R
C
T
CMLGA
T
PFV
Y
DL
LN
L
L
E
K
QP
AD
-
-----
-
LS
A
LRF
F
L
CGGT
TIPKK
V
A
R
E
-----
C
QQ
L
G
I
K
---
LL
SV
YG
S
TE
S
SPHA
V
V
N
L
--
D
D
P
L
-S
R
FMH
-
T
D
G
Y
A
A
A
GVE
IK
V
V
N
D
ARK
T
LP
P
G
C
EGE
--
-
EA
S
---
R
G
P
N
V
F
-------
MG
YF
DE
P
EL
TA
R
A
L
DEE
GWY
Y
SGD
LC
R
M
DE
A
GY
IK
ITGR
KK
D
I
I
V
RGGEN
I
S
SR
E
V
E
D
IL
LQ
HPKI
H
DA
C
VV
AM
PD
E
R
L
GE
RS
C
AYVVL
K
A
PHH
S
LS
L
EE
V
--
V
A
F
F
S
RK
R
V
AK
Y
K
Y
P
EH
I
VVI
E
K
LPRT
A
SGKI
QKFL
LRK
DI
fig|469008.4.peg.2003
Escherichia coli BL21(DE3) (38-553/566)
LW
G
DAS
L
ADY
W
QQT
A
RAMP
DK
I
A
V
V
D
N
-
HG
A
T
----
Y
T
Y
S
A
L
D
HAAS
C
L
AN
WM
L
A
K
GI
E
S
GD
R
I
A
FQ
LP
GW
C
EF
T
V
IY
LAC
L
KIGAV
S
VP
L
LPSWRE
A
E
L
V
W
V
L
NK
C
QA
K
M
F-
--
--
F
A
P
T
LFK
Q
TR
PVDLILPL
Q
N
QLP
QL
Q
Q
I
V
G
---
VD
K
LA
--
PA
TS
S
L
S
LSQI
IA
D
-------------------
N
I
P
--
L
TT
A
ITT
H
G
D
E
L
A
A
V
LFTSGT
E
G
L
PKGV
M
L
TH
N
N
I
L
ASERA
Y
C
A
R
L
NLT
W
L
------
DV
F
MMP
AP
L
GH
A
TG
FLHGVT
APF
LI
GA
R
S
VL
L
D
IF
----
TP
D
A
CLAL
L
E
Q
Q
R
C
T
CMLGA
T
PFV
Y
DL
LN
L
L
E
K
QP
AD
-
-----
-
LS
A
LRF
F
L
CGGT
TIPKK
V
A
R
E
-----
C
QQ
L
G
I
K
---
LL
SV
YG
S
TE
S
SPHA
V
V
N
L
--
D
D
P
L
-S
R
FMH
-
T
D
G
Y
A
A
A
GVE
IK
V
V
N
D
ARK
T
LP
P
G
C
EGE
--
-
EA
S
---
R
G
P
N
V
F
-------
MG
YF
DE
P
EL
TA
R
A
L
DEE
GWY
Y
SGD
LC
R
M
DE
A
GY
IK
ITGR
KK
D
I
I
V
RGGEN
I
S
SR
E
V
E
D
IL
LQ
HPKI
H
DA
C
VV
AM
PD
E
R
L
GE
RS
C
AYVVL
K
A
PHH
S
LS
L
EE
V
--
V
A
F
F
S
RK
R
V
AK
Y
K
Y
P
EH
I
VVI
E
K
LPRT
A
SGKI
QKFL
LRK
DI
fig|656419.3.peg.2415
Escherichia coli M718 (20-535/548)
LW
G
DAS
L
ADY
W
QQT
A
RAMP
DK
I
A
V
V
D
N
-
HG
AS
----
Y
T
Y
S
A
L
D
HAAS
C
L
AN
WM
L
A
K
GI
E
S
G
A
R
I
A
FQ
LP
GW
C
EF
T
V
IY
LAC
L
KIGAV
S
VP
L
LPSWRE
A
E
L
V
W
V
L
NK
C
QA
K
M
F-
--
--
F
A
P
T
LFK
Q
TR
PVDLILPL
Q
N
QLP
QL
Q
Q
I
V
G
---
VD
K
LA
--
PA
TS
S
L
S
LSQI
IA
D
-------------------
N
T
P
--
L
TT
A
ITT
H
G
D
E
L
A
A
V
LFTSGT
E
G
L
PKGV
M
L
TH
N
N
I
L
ASERA
Y
C
A
R
L
NLT
WQ
------
DV
F
MMP
AP
L
GH
A
TG
FLHGVT
APF
LI
GA
R
S
VL
L
D
IF
----
TP
D
A
CLAL
L
E
Q
Q
R
C
T
CMLGA
T
PFV
Y
DL
LN
L
L
E
K
QP
AD
-
-----
-
LS
A
LRF
F
L
CGGT
TIPKK
V
A
R
E
-----
C
QQ
R
G
I
K
---
LL
SV
YG
S
TE
S
SPHA
V
V
N
L
--
D
D
P
L
-S
R
FMH
-
T
D
G
Y
A
A
A
GVE
IK
V
VDD
ARK
T
LP
P
G
C
EGE
--
-
EA
S
---
R
G
P
N
V
F
-------
MG
YF
DE
P
EL
TA
R
A
L
DEE
GWY
Y
SGD
LC
R
M
DE
A
GY
IK
ITGR
KK
D
I
I
V
RGGEN
I
S
SR
E
V
E
D
IL
LQ
HPKI
H
DA
C
VV
AM
PD
E
R
L
GE
RS
C
AYVVL
K
A
PHH
S
LS
L
EE
V
--
V
A
F
F
S
RK
R
V
AK
Y
K
Y
P
EH
I
VVI
E
K
LPRT
A
SGKI
QKFL
LRK
DI
fig|562.375.peg.1812
Escherichia coli EC4100B (20-535/548)
LW
G
DAS
L
ADY
W
QQT
A
RAMP
DK
I
A
V
V
D
N
-
HG
AS
----
Y
T
Y
S
A
L
D
HAAS
C
L
AN
WM
L
A
K
GI
E
S
GD
R
I
A
FQ
LP
GW
C
EF
T
V
IY
LAC
L
K
T
GAV
S
VP
L
LPSWRE
A
E
L
V
W
V
L
NK
C
QA
K
M
F-
--
--
F
A
P
T
LFK
Q
TR
PVDLILPL
Q
N
QLP
QL
Q
Q
I
V
G
---
VD
K
LA
--
PA
TS
S
L
S
LSQI
IA
D
-------------------
N
T
S
--
L
TT
A
ITT
H
G
D
E
L
A
A
V
LFTSGT
E
G
L
PKGV
M
L
TH
N
N
I
L
ASERA
Y
C
A
R
L
NLT
WQ
------
DV
F
MMP
AP
L
GH
A
TG
FLHGVT
APF
LI
GA
R
S
VL
L
D
IF
----
TP
D
A
CLAL
L
E
Q
Q
R
C
T
CMLGA
T
PFV
Y
DL
LN
V
L
E
K
QP
AD
-
-----
-
LS
A
LRF
F
L
CGGT
TIPKK
V
A
R
E
-----
C
QQ
R
G
I
K
---
LL
SV
YG
S
TE
S
SPHA
V
V
N
L
--
D
D
P
L
-S
R
FMH
-
T
D
G
Y
A
A
A
GVE
IK
V
VDD
ARK
T
LP
P
G
C
EGE
--
-
EA
S
---
R
G
P
N
V
F
-------
MG
YF
DE
P
EL
TA
R
A
L
DEE
GWY
Y
SGD
LC
R
M
DE
A
GY
IK
ITGR
KK
D
I
I
V
RGGEN
I
S
SR
E
V
E
D
IL
LQ
HPKI
H
DA
C
VV
AM
PD
E
R
L
GE
RS
C
AYVVL
K
A
PHH
S
LS
L
EE
V
--
V
A
F
F
S
RK
R
V
AK
Y
K
Y
P
EH
I
VVI
E
K
LPRT
A
SGKI
QKFL
LRK
DI
fig|679207.4.peg.3292
Escherichia coli MS 107-1 (20-535/548)
LW
G
DAS
L
ADY
W
QQT
A
RAMP
DK
I
A
V
V
D
N
-
HG
AS
----
Y
T
Y
S
A
L
D
HAAS
C
L
AN
WM
L
A
K
GI
E
S
GD
R
I
A
FQ
LP
GW
C
EF
T
V
IY
LAC
L
K
T
GAV
S
VP
L
LPSWRE
A
E
L
V
W
V
L
NK
C
QA
K
M
F-
--
--
F
A
P
T
LFK
Q
TR
PVDLILPL
Q
N
QLP
QL
Q
Q
I
V
G
---
VD
K
LA
--
PA
TS
S
L
S
LSQI
IA
D
-------------------
N
T
S
--
L
TT
A
ITT
H
G
D
E
L
A
A
V
LFTSGT
E
G
L
PKGV
M
L
TH
N
N
I
L
ASERA
Y
C
A
R
L
NLT
WQ
------
DV
F
MMP
AP
L
GH
A
TG
FLHGVT
APF
LI
GA
R
S
VL
L
D
IF
----
TP
D
A
CLAL
L
E
Q
Q
R
C
T
CMLGA
T
PFV
Y
DL
LN
V
L
E
K
QP
AD
-
-----
-
LS
A
LRF
F
L
CGGT
TIPKK
V
A
R
E
-----
C
QQ
R
G
I
K
---
LL
SV
YG
S
TE
S
SPHA
V
V
N
L
--
D
D
P
L
-S
R
FMH
-
T
D
G
Y
A
A
A
GVE
IK
V
VDD
ARK
T
LP
P
G
C
EGE
--
-
EA
S
---
R
G
P
N
V
F
-------
MG
YF
DE
P
EL
TA
R
A
L
DEE
GWY
Y
SGD
LC
R
M
DE
A
GY
IK
ITGR
KK
D
I
I
V
RGGEN
I
S
SR
E
V
E
D
IL
LQ
HPKI
H
DA
C
VV
AM
PD
E
R
L
GE
RS
C
AYVVL
K
A
PHH
S
LS
L
EE
V
--
V
A
F
F
S
RK
R
V
AK
Y
K
Y
P
EH
I
VVI
E
K
LPRT
A
SGKI
QKFL
LRK
DI
fig|679205.4.peg.5049
Escherichia coli MS 124-1 (20-535/548)
LW
G
DAS
L
ADY
W
QQT
A
RAMP
DK
I
A
V
V
D
N
-
HG
AS
----
Y
T
Y
S
A
L
D
HAAS
C
L
AN
WM
L
A
K
GI
E
S
GD
R
I
A
FQ
LP
GW
C
EF
T
V
IY
LAC
L
K
T
GAV
S
VP
L
LPSWRE
A
E
L
V
W
V
L
NK
C
QA
K
M
F-
--
--
F
A
P
T
LFK
Q
TR
PVDLILPL
Q
N
QLP
QL
Q
Q
I
V
G
---
VD
K
LA
--
PA
TS
S
L
S
LSQI
IA
D
-------------------
N
T
S
--
L
TT
A
ITT
H
G
D
E
L
A
A
V
LFTSGT
E
G
L
PKGV
M
L
TH
N
N
I
L
ASERA
Y
C
A
R
L
NLT
WQ
------
DV
F
MMP
AP
L
GH
A
TG
FLHGVT
APF
LI
GA
R
S
VL
L
D
IF
----
TP
D
A
CLAL
L
E
Q
Q
R
C
T
CMLGA
T
PFV
Y
DL
LN
V
L
E
K
QP
AD
-
-----
-
LS
A
LRF
F
L
CGGT
TIPKK
V
A
R
E
-----
C
QQ
R
G
I
K
---
LL
SV
YG
S
TE
S
SPHA
V
V
N
L
--
D
D
P
L
-S
R
FMH
-
T
D
G
Y
A
A
A
GVE
IK
V
VDD
ARK
T
LP
P
G
C
EGE
--
-
EA
S
---
R
G
P
N
V
F
-------
MG
YF
DE
P
EL
TA
R
A
L
DEE
GWY
Y
SGD
LC
R
M
DE
A
GY
IK
ITGR
KK
D
I
I
V
RGGEN
I
S
SR
E
V
E
D
IL
LQ
HPKI
H
DA
C
VV
AM
PD
E
R
L
GE
RS
C
AYVVL
K
A
PHH
S
LS
L
EE
V
--
V
A
F
F
S
RK
R
V
AK
Y
K
Y
P
EH
I
VVI
E
K
LPRT
A
SGKI
QKFL
LRK
DI
fig|749533.3.peg.2660
Escherichia coli MS 84-1 (20-535/548)
LW
G
DAS
L
ADY
W
QQT
A
RAMP
DK
I
A
V
V
D
N
-
HG
AS
----
Y
T
Y
S
A
L
D
HAAS
C
L
AN
WM
L
A
K
GI
E
S
GD
R
I
A
FQ
LP
GW
C
EF
T
V
IY
LAC
L
K
T
GAV
S
VP
L
LPSWRE
A
E
L
V
W
V
L
NK
C
QA
K
M
F-
--
--
F
A
P
T
LFK
Q
TR
PVDLILPL
Q
N
QLP
QL
Q
Q
I
V
G
---
VD
K
LA
--
PA
TS
S
L
S
LSQI
IA
D
-------------------
N
T
S
--
L
TT
A
ITT
H
G
D
E
L
A
A
V
LFTSGT
E
G
L
PKGV
M
L
TH
N
N
I
L
ASERA
Y
C
A
R
L
NLT
WQ
------
DV
F
MMP
AP
L
GH
A
TG
FLHGVT
APF
LI
GA
R
S
VL
L
D
IF
----
TP
D
A
CLAL
L
E
Q
Q
R
C
T
CMLGA
T
PFV
Y
DL
LN
V
L
E
K
QP
AD
-
-----
-
LS
A
LRF
F
L
CGGT
TIPKK
V
A
R
E
-----
C
QQ
R
G
I
K
---
LL
SV
YG
S
TE
S
SPHA
V
V
N
L
--
D
D
P
L
-S
R
FMH
-
T
D
G
Y
A
A
A
GVE
IK
V
VDD
ARK
T
LP
P
G
C
EGE
--
-
EA
S
---
R
G
P
N
V
F
-------
MG
YF
DE
P
EL
TA
R
A
L
DEE
GWY
Y
SGD
LC
R
M
DE
A
GY
IK
ITGR
KK
D
I
I
V
RGGEN
I
S
SR
E
V
E
D
IL
LQ
HPKI
H
DA
C
VV
AM
PD
E
R
L
GE
RS
C
AYVVL
K
A
PHH
S
LS
L
EE
V
--
V
A
F
F
S
RK
R
V
AK
Y
K
Y
P
EH
I
VVI
E
K
LPRT
A
SGKI
QKFL
LRK
DI
fig|656414.3.peg.2020
Escherichia coli H736 (20-535/548)
LW
G
DAS
L
ADY
W
QQT
A
RAMP
DK
I
A
V
V
D
N
-
HG
AS
----
Y
T
Y
S
A
L
D
HAAS
C
L
AN
WM
L
A
K
GI
E
S
GD
R
I
A
FQ
LP
GW
C
EF
T
V
IY
LAC
L
KIGAV
S
VP
L
LPSWRE
A
E
L
V
W
V
L
NK
C
QA
K
M
F-
--
--
F
A
P
T
LFK
Q
TR
PVDLILPL
Q
N
QLP
QL
Q
Q
I
V
G
---
VD
K
LA
--
PA
TS
S
L
S
LSQI
IA
D
-------------------
N
T
S
--
L
TT
A
ITT
H
G
D
E
L
A
A
V
LFTSGT
E
G
L
PKGV
M
L
TH
N
N
I
L
ASERA
Y
C
A
R
L
NLT
WQ
------
DV
F
MMP
AP
L
GH
A
TG
FLHGVT
APF
LI
GA
R
S
VL
L
D
IF
----
TP
D
A
CLAL
L
E
Q
Q
R
C
T
CMLGA
T
PFV
Y
DL
LN
V
L
E
K
QP
AD
-
-----
-
LS
A
LRF
F
L
CGGT
TIPKK
V
A
R
E
-----
C
QQ
R
G
I
K
---
LL
SV
YG
S
TE
S
SPHA
V
V
N
L
--
D
D
P
L
-S
H
FMH
-
T
D
G
Y
A
A
A
GVE
IK
V
VDD
ARK
T
LP
P
G
C
EGE
--
-
EA
S
---
R
G
P
N
V
F
-------
MG
YF
DE
P
EL
TA
R
A
L
DEE
GWY
Y
SGD
LC
R
M
DE
A
GY
IK
ITGR
KK
D
I
I
V
RGGEN
I
S
SR
E
V
E
D
IL
LQ
HPKI
H
DA
C
VV
AM
S
D
E
R
L
GE
RS
C
AYVVL
K
A
PHH
S
LS
L
EE
V
--
V
A
F
F
S
RK
R
V
AK
Y
K
Y
P
EH
I
VVI
E
K
LPRT
T
SGKI
QKFL
LRK
DI
fig|749540.3.peg.4114
Escherichia coli MS 146-1 (20-535/548)
LW
G
DAS
L
ADY
W
QQT
A
RAMP
DK
I
A
V
V
D
N
-
HG
AS
----
Y
T
Y
S
A
L
D
HAAS
C
L
AN
WM
L
A
K
GI
E
S
GD
R
I
A
FQ
LP
GW
C
EF
T
V
IY
LAC
L
KIGAV
S
VP
L
LPSWRE
A
E
L
V
W
V
L
NK
C
QA
K
M
F-
--
--
F
A
P
T
LFK
Q
TR
PVDLILPL
Q
N
QLP
QL
Q
Q
I
V
G
---
VD
K
LA
--
PA
TS
S
L
S
LSQI
IA
D
-------------------
N
T
S
--
L
TT
A
ITT
H
G
D
E
L
A
A
V
LFTSGT
E
G
L
PKGV
M
L
TH
N
N
I
L
ASERA
Y
C
A
R
L
NLT
WQ
------
DV
F
MMP
AP
L
GH
A
TG
FLHGVT
APF
LI
GA
R
S
VL
L
D
IF
----
TP
D
A
CLAL
L
E
Q
Q
R
C
T
CMLGA
T
PFV
Y
DL
LN
V
L
E
K
QP
AD
-
-----
-
LS
A
LRF
F
L
CGGT
TIPKK
V
A
R
E
-----
C
QQ
R
G
I
K
---
LL
SV
YG
S
TE
S
SPHA
V
V
N
L
--
D
D
P
L
-S
H
FMH
-
T
D
G
Y
A
A
A
GVE
IK
V
VDD
ARK
T
LP
P
G
C
EGE
--
-
EA
S
---
R
G
P
N
V
F
-------
MG
YF
DE
P
EL
TA
R
A
L
DEE
GWY
Y
SGD
LC
R
M
DE
A
GY
IK
ITGR
KK
D
I
I
V
RGGEN
I
S
SR
E
V
E
D
IL
LQ
HPKI
H
DA
C
VV
AM
S
D
E
R
L
GE
RS
C
AYVVL
K
A
PHH
S
LS
L
EE
V
--
V
A
F
F
S
RK
R
V
AK
Y
K
Y
P
EH
I
VVI
E
K
LPRT
T
SGKI
QKFL
LRK
DI
fig|670897.3.peg.2536
Escherichia coli 2362-75 (20-535/548)
LW
G
DAS
L
ADY
W
QQT
A
RAMP
DK
I
A
V
V
D
N
-
HG
A
T
----
Y
T
Y
S
A
L
D
HAAS
C
L
A
Y
WM
L
A
K
GI
E
S
GD
R
I
A
FQ
LP
GW
C
EF
T
V
IY
LAC
L
K
T
GAV
S
VP
L
LPSWRE
A
E
L
V
W
V
L
NK
C
QA
K
M
F-
--
--
F
A
P
T
LFK
Q
TR
PVDLILPL
Q
N
QLP
QL
Q
Q
I
V
G
---
VD
K
L
S
--
PA
TS
S
L
S
LSQI
L
A
D
-------------------
N
T
P
--
L
TT
A
ITT
H
G
D
E
L
A
A
V
LFTSGT
E
G
L
PKGV
M
L
TH
N
N
I
L
ASERA
Y
C
A
R
L
NLT
WQ
------
DV
F
MMP
AP
L
GH
A
TG
FLHGVT
APF
LI
GA
R
S
VL
L
D
IF
----
TP
D
A
CLAL
L
E
Q
Q
R
C
T
CMLGA
T
PFV
Y
DL
LN
L
L
E
K
QP
AD
-
-----
-
LS
A
LRF
F
L
CGGT
TIPKK
V
A
R
E
-----
C
QQ
R
G
I
K
---
LL
SV
YG
S
TE
S
SPHA
V
V
N
L
--
D
D
P
L
-P
R
FMH
-
T
D
G
Y
A
A
A
GVE
IK
V
VDD
ARK
T
LP
P
G
C
EGE
--
-
EA
S
---
R
G
P
N
V
F
-------
MG
YF
DE
P
EL
TA
R
A
L
DEE
GWY
Y
SGD
LC
R
M
DE
A
GY
IK
ITGR
KK
D
I
I
V
RGGEN
I
S
SR
E
V
E
D
IL
LQ
HPKI
H
DA
C
VV
AM
PD
E
R
L
GE
RS
C
AYVVL
K
A
PHH
S
LS
L
EE
V
--
V
A
F
F
S
RK
R
V
AK
Y
K
Y
P
EH
I
VVI
E
K
LPRT
V
SGKI
QKFL
LRK
DI
fig|316401.4.peg.1989
Escherichia coli ETEC H10407 (20-535/548)
LW
G
DAS
L
ADY
W
QQT
A
RAMP
DK
I
A
V
V
D
N
-
HG
AS
----
Y
T
Y
S
A
L
D
HAAS
C
L
AN
WM
L
A
K
GI
E
S
GD
R
I
A
FQ
LP
GW
C
EF
T
V
IY
LAC
L
KIGAV
S
VP
L
LPSWRE
A
E
L
V
W
V
L
NK
C
QA
K
M
F-
--
--
F
A
P
T
LFK
Q
TR
PVDLILPL
Q
N
QLP
QL
Q
Q
I
V
G
---
VD
K
LA
--
PA
TS
S
L
S
LSQI
IA
D
-------------------
N
T
S
--
L
TT
A
ITT
H
G
D
E
L
A
A
V
LFTSGT
E
G
L
PKGV
M
L
TH
N
N
I
L
ASERA
Y
C
A
R
L
NLT
WQ
------
DV
F
MMP
AP
L
GH
A
TG
FLHGVT
APF
LI
GA
R
S
VL
L
D
IF
----
TP
D
A
CLAL
L
E
Q
Q
R
C
T
CMLGA
T
PFV
Y
DL
LN
V
L
E
K
QP
AD
-
-----
-
LS
A
LRF
F
L
CGGT
TIPKK
V
A
R
E
-----
C
QQ
R
G
I
K
---
LL
SV
YG
S
TE
S
SPHA
V
V
N
L
--
D
D
P
L
-S
R
FMH
-
T
D
G
Y
A
A
A
GVE
IK
V
VDD
ARK
T
LP
P
G
C
EGE
--
-
EA
S
---
R
G
P
N
V
F
-------
MG
YF
DE
P
EL
TA
R
A
L
DEE
GWY
Y
SGD
LC
R
M
DE
A
GY
IK
ITGR
KK
D
I
I
V
RGGEN
I
S
SR
E
V
E
D
IL
LQ
HPKI
H
DA
C
VV
AM
S
D
E
R
L
GE
RS
C
AYVVL
K
A
PHH
S
LS
L
EE
V
--
V
A
F
F
S
RK
R
V
AK
Y
K
Y
P
EH
I
VVI
E
K
LP
L
T
T
SGKI
QKFL
LRK
DI
fig|550676.3.peg.4340
Escherichia coli B185 (90-616/652)
GD
R
TAII
W
E
G
DD
AS
QSKH
I
SY
K
ELH
RDVC
R
F
AN
TL
L
E
LGIKKGD
V
VA
IY
M
P
MV
PE
A
A
V
AM
LACA
R
IGAV
H
SV
I
FGGFSP
E
A
V
A
G
R
I
ID
S
NS
R
L
VI
TS
--
-
-
-
-
---
-
--
--------
D
E
GVR
AG
R
S
I
P
L
KKN
VD
D
AL
KN
P
N
VT
SV
E
HVVV
LK
R
TGGKIDWQEGRDLWWHD
Q
V
E
Q
A
SD
Q
HQ
A
EEM
N
A
E
D
P
L
F
IL
Y
TSG
S
TG
K
PKGVL
H
T
T
G
G
Y
L
----V
Y
A
A
-
L
TFK
YV
FDYHPG
D
I
Y
WCT
A
D
V
G
W
V
TG
HSYLLY
G
P
L
AC
GAT
T
LM
F
E
GV
PNWP
TP
A
R
MAQV
VDK
H
Q
V
N
----
I
L
YTA
P
TA
IR
A
LM
A
EG
DK
A
IEGTD
R
-
S
S
LR
I
L
G
----
SVGEP
IN
P
E
AWEWY
W
KK
I
G
N
K
KCPVV
DT
WW
Q
TET
GGFM
I
T
P
L
--
-
-
PG
AT
E
LKA
G
S
A
T
R
P
F
FGV
Q
PA
LVD
N
EGN
PL
E
G
A
T
EG
S
LV
I
TD
S
WPG
Q
A
R
TLF
GDHERFE
QT
YF
--
-
-S
T
F
K
N
M
---
--
YFSGD
GA
RRDE
D
GY
YW
ITGR
VD
DV
L
N
VS
G
HR
L
G
TA
EIES
A
L
VA
HPKI
A
E
A
A
VVGIP
H
N
I
K
G
Q
AI
Y
AYV
T
LN
H
-
GE
E
P
S
P
E
L
Y
AE
VR
N
W
V
RK
E
I
GP
L
A
T
P
DV
L
HWT
D
S
LP
K
T
R
SGKI
MRRI
LR
fig|685038.3.peg.4161
Escherichia coli O83:H1 str. NRG 857C (90-616/652)
GD
R
TAII
W
E
G
DD
AS
QSKH
I
SY
K
ELH
RDVC
R
F
AN
TL
L
E
LGIKKGD
V
VA
IY
M
P
MV
PE
A
A
V
AM
LACA
R
IGAV
H
SV
I
FGGFSP
E
A
V
A
G
R
I
ID
S
S
S
R
L
VI
TS
--
-
-
-
-
---
-
--
--------
D
E
GVR
AG
R
S
I
P
L
KKN
VD
D
AL
KN
P
N
VT
SV
E
HVVV
LK
R
T
S
GKIDWQEGRDLWWHDLV
E
Q
A
SA
Q
HQ
A
EEM
N
A
E
D
P
L
F
IL
Y
TSG
S
TG
K
PKGVL
H
T
T
A
G
Y
L
----V
Y
A
A
-
L
TFK
YV
FDYHPG
D
I
Y
WCT
A
D
V
G
W
V
TG
HSYLLY
G
P
L
AC
GAT
T
LM
F
E
GV
PNWP
TP
A
R
MAQV
VDK
H
Q
V
N
----
I
L
YTA
P
TA
IR
A
LM
A
EG
DK
A
IEGTD
R
-
S
S
LR
I
L
G
----
SVGEP
IN
P
E
AWEWY
W
KK
I
G
N
E
KCPVV
DT
WW
Q
TET
GGFM
I
T
P
L
--
-
-
PG
AT
E
LKA
G
S
A
T
R
P
F
FGV
Q
PA
LVD
N
EGN
PL
E
G
A
T
EG
S
LV
I
TD
S
WPG
Q
A
R
TLF
GDHERFE
QT
YF
--
-
-S
T
F
K
N
M
---
--
YFSGD
GA
RRDE
D
GY
YW
ITGR
VD
DV
L
N
VS
G
HR
L
G
TA
EIES
A
L
VA
HPKI
A
E
A
A
VVGIP
H
N
I
K
G
Q
AI
Y
AYV
T
LN
H
-
GE
E
P
S
P
E
L
Y
AE
VR
N
W
V
RK
E
I
GP
L
A
T
P
DV
L
HWT
D
S
LP
K
T
R
SGKI
MRRI
LR
fig|753642.3.peg.4076
Escherichia coli NC101 (90-616/652)
GD
R
TAII
W
E
G
DD
AS
QSKH
I
SY
K
ELH
RDVC
R
F
AN
TL
L
E
LGIKKGD
V
VA
IY
M
P
MV
PE
A
A
V
AM
LACA
R
IGAV
H
SV
I
FGGFSP
E
A
V
A
G
R
I
ID
S
S
S
R
L
VI
TS
--
-
-
-
-
---
-
--
--------
D
E
GVR
AG
R
S
I
P
L
KKN
VD
D
AL
KN
P
N
VT
SV
E
HVVV
LK
R
TGGKIDWQEGRDLWWHDLV
E
Q
A
SA
Q
HQ
A
EEM
N
A
E
D
P
L
F
IL
Y
TSG
S
TG
K
PKGVL
H
T
T
G
G
Y
L
----V
Y
A
A
-
L
TFK
YV
FDYHPG
D
I
Y
WCT
A
D
V
G
W
V
TG
HSYLLY
G
P
L
AC
GAT
T
LM
F
E
GV
PNWP
TP
A
R
MAQV
VDK
H
Q
V
N
----
I
L
YTA
P
TA
IR
A
LM
A
EG
DK
A
IEGTD
R
-
S
S
LR
I
L
G
----
SVGEP
IN
P
E
AWEWY
W
KK
I
G
N
E
KCPVV
DT
WW
Q
TET
GGFM
I
T
P
L
--
-
-
PG
AT
E
LKA
G
S
A
T
R
P
F
FGV
Q
PA
LVD
N
EGH
PL
E
G
A
T
EG
S
LV
I
TD
S
WPG
Q
A
R
TLF
GDHERFE
QT
YF
--
-
-S
T
F
K
N
M
---
--
YFSGD
GA
RRDE
D
GY
YW
ITGR
VD
DV
L
N
VS
G
HR
L
G
TA
EIES
A
L
VA
HPKI
A
E
A
A
VVGIP
H
N
I
K
G
Q
AI
Y
AYV
T
LN
H
-
GE
E
P
S
P
E
L
Y
AE
VR
N
W
V
RK
E
I
GP
L
A
T
P
DV
L
HWT
D
S
LP
K
T
R
SGKI
MRRI
LR
fig|362663.8.peg.4335
Escherichia coli 536 (90-616/652)
GD
R
TAII
W
E
G
DD
AS
QSKH
I
SY
K
ELH
RDVC
R
F
AN
TL
L
E
LGIKKGD
V
VA
IY
M
P
MV
PE
A
A
V
AM
LACA
R
IGAV
H
SV
I
FGGFSP
E
A
V
A
G
R
I
ID
S
S
S
R
L
VI
TS
--
-
-
-
-
---
-
--
--------
D
E
GVR
AG
R
S
I
P
L
KKN
VD
D
AL
KN
P
N
VT
SV
E
HVVV
LK
R
TGGKIDWQEGRDLWWHDLV
E
Q
A
SA
Q
HQ
A
EEM
N
A
E
D
P
L
F
IL
Y
TSG
S
TG
K
PKGVL
H
T
T
G
G
Y
L
----V
Y
A
A
-
L
TFK
YV
FDYHPG
D
I
Y
WCT
A
D
V
G
W
V
TG
HSYLLY
G
P
L
AC
GAT
T
LM
F
E
GV
PNWP
TP
A
R
MAQV
VDK
H
Q
V
N
----
I
L
YTA
P
TA
IR
A
LM
A
EG
DK
A
IEGTD
R
-
S
S
LR
I
L
G
----
SVGEP
IN
P
E
AWEWY
W
KK
I
G
N
E
KCPVV
DT
WW
Q
TET
GGFM
I
T
P
L
--
-
-
PG
AT
E
LKA
G
S
A
T
R
P
F
FGV
Q
PA
LVD
N
EGN
PL
E
G
A
T
EG
S
LV
I
TD
S
WPG
Q
A
R
TLF
GDHERFE
QT
YF
--
-
-S
T
F
K
N
M
---
--
YFSGD
GA
RRDE
D
GY
YW
ITGR
VD
DV
L
N
VS
G
HR
L
G
TA
EIES
A
L
VA
HPKI
A
E
A
A
VVGIP
H
N
I
K
G
Q
AI
Y
AYV
T
LN
H
-
GE
E
P
S
P
E
L
Y
AE
VR
N
W
V
RK
E
I
GP
L
A
T
P
DV
L
HWT
D
S
LP
K
T
R
SGKI
MRRI
LR
fig|362663.9.peg.4351
Escherichia coli 536 (90-616/652)
GD
R
TAII
W
E
G
DD
AS
QSKH
I
SY
K
ELH
RDVC
R
F
AN
TL
L
E
LGIKKGD
V
VA
IY
M
P
MV
PE
A
A
V
AM
LACA
R
IGAV
H
SV
I
FGGFSP
E
A
V
A
G
R
I
ID
S
S
S
R
L
VI
TS
--
-
-
-
-
---
-
--
--------
D
E
GVR
AG
R
S
I
P
L
KKN
VD
D
AL
KN
P
N
VT
SV
E
HVVV
LK
R
TGGKIDWQEGRDLWWHDLV
E
Q
A
SA
Q
HQ
A
EEM
N
A
E
D
P
L
F
IL
Y
TSG
S
TG
K
PKGVL
H
T
T
G
G
Y
L
----V
Y
A
A
-
L
TFK
YV
FDYHPG
D
I
Y
WCT
A
D
V
G
W
V
TG
HSYLLY
G
P
L
AC
GAT
T
LM
F
E
GV
PNWP
TP
A
R
MAQV
VDK
H
Q
V
N
----
I
L
YTA
P
TA
IR
A
LM
A
EG
DK
A
IEGTD
R
-
S
S
LR
I
L
G
----
SVGEP
IN
P
E
AWEWY
W
KK
I
G
N
E
KCPVV
DT
WW
Q
TET
GGFM
I
T
P
L
--
-
-
PG
AT
E
LKA
G
S
A
T
R
P
F
FGV
Q
PA
LVD
N
EGN
PL
E
G
A
T
EG
S
LV
I
TD
S
WPG
Q
A
R
TLF
GDHERFE
QT
YF
--
-
-S
T
F
K
N
M
---
--
YFSGD
GA
RRDE
D
GY
YW
ITGR
VD
DV
L
N
VS
G
HR
L
G
TA
EIES
A
L
VA
HPKI
A
E
A
A
VVGIP
H
N
I
K
G
Q
AI
Y
AYV
T
LN
H
-
GE
E
P
S
P
E
L
Y
AE
VR
N
W
V
RK
E
I
GP
L
A
T
P
DV
L
HWT
D
S
LP
K
T
R
SGKI
MRRI
LR
fig|525281.3.peg.1809
Escherichia coli 83972 (90-616/652)
GD
R
TAII
W
E
G
DD
AS
QSKH
I
SY
K
ELH
RDVC
R
F
AN
TL
L
E
LGIKKGD
V
VA
IY
M
P
MV
PE
A
A
V
AM
LACA
R
IGAV
H
SV
I
FGGFSP
E
A
V
A
G
R
I
ID
S
S
S
R
L
VI
TS
--
-
-
-
-
---
-
--
--------
D
E
GVR
AG
R
S
I
P
L
KKN
VD
D
AL
KN
P
N
VT
SV
E
HVVV
LK
R
TGGKIDWQEGRDLWWHDLV
E
Q
A
SA
Q
HQ
A
EEM
N
A
E
D
P
L
F
IL
Y
TSG
S
TG
K
PKGVL
H
T
T
G
G
Y
L
----V
Y
A
A
-
L
TFK
YV
FDYHPG
D
I
Y
WCT
A
D
V
G
W
V
TG
HSYLLY
G
P
L
AC
GAT
T
LM
F
E
GV
PNWP
TP
A
R
MAQV
VDK
H
Q
V
N
----
I
L
YTA
P
TA
IR
A
LM
A
EG
DK
A
IEGTD
R
-
S
S
LR
I
L
G
----
SVGEP
IN
P
E
AWEWY
W
KK
I
G
N
E
KCPVV
DT
WW
Q
TET
GGFM
I
T
P
L
--
-
-
PG
AT
E
LKA
G
S
A
T
R
P
F
FGV
Q
PA
LVD
N
EGN
PL
E
G
A
T
EG
S
LV
I
TD
S
WPG
Q
A
R
TLF
GDHERFE
QT
YF
--
-
-S
T
F
K
N
M
---
--
YFSGD
GA
RRDE
D
GY
YW
ITGR
VD
DV
L
N
VS
G
HR
L
G
TA
EIES
A
L
VA
HPKI
A
E
A
A
VVGIP
H
N
I
K
G
Q
AI
Y
AYV
T
LN
H
-
GE
E
P
S
P
E
L
Y
AE
VR
N
W
V
RK
E
I
GP
L
A
T
P
DV
L
HWT
D
S
LP
K
T
R
SGKI
MRRI
LR
fig|655817.3.peg.4807
Escherichia coli ABU 83972 (90-616/652)
GD
R
TAII
W
E
G
DD
AS
QSKH
I
SY
K
ELH
RDVC
R
F
AN
TL
L
E
LGIKKGD
V
VA
IY
M
P
MV
PE
A
A
V
AM
LACA
R
IGAV
H
SV
I
FGGFSP
E
A
V
A
G
R
I
ID
S
S
S
R
L
VI
TS
--
-
-
-
-
---
-
--
--------
D
E
GVR
AG
R
S
I
P
L
KKN
VD
D
AL
KN
P
N
VT
SV
E
HVVV
LK
R
TGGKIDWQEGRDLWWHDLV
E
Q
A
SA
Q
HQ
A
EEM
N
A
E
D
P
L
F
IL
Y
TSG
S
TG
K
PKGVL
H
T
T
G
G
Y
L
----V
Y
A
A
-
L
TFK
YV
FDYHPG
D
I
Y
WCT
A
D
V
G
W
V
TG
HSYLLY
G
P
L
AC
GAT
T
LM
F
E
GV
PNWP
TP
A
R
MAQV
VDK
H
Q
V
N
----
I
L
YTA
P
TA
IR
A
LM
A
EG
DK
A
IEGTD
R
-
S
S
LR
I
L
G
----
SVGEP
IN
P
E
AWEWY
W
KK
I
G
N
E
KCPVV
DT
WW
Q
TET
GGFM
I
T
P
L
--
-
-
PG
AT
E
LKA
G
S
A
T
R
P
F
FGV
Q
PA
LVD
N
EGN
PL
E
G
A
T
EG
S
LV
I
TD
S
WPG
Q
A
R
TLF
GDHERFE
QT
YF
--
-
-S
T
F
K
N
M
---
--
YFSGD
GA
RRDE
D
GY
YW
ITGR
VD
DV
L
N
VS
G
HR
L
G
TA
EIES
A
L
VA
HPKI
A
E
A
A
VVGIP
H
N
I
K
G
Q
AI
Y
AYV
T
LN
H
-
GE
E
P
S
P
E
L
Y
AE
VR
N
W
V
RK
E
I
GP
L
A
T
P
DV
L
HWT
D
S
LP
K
T
R
SGKI
MRRI
LR
fig|199310.1.peg.4959
Escherichia coli CFT073 (90-616/652)
GD
R
TAII
W
E
G
DD
AS
QSKH
I
SY
K
ELH
RDVC
R
F
AN
TL
L
E
LGIKKGD
V
VA
IY
M
P
MV
PE
A
A
V
AM
LACA
R
IGAV
H
SV
I
FGGFSP
E
A
V
A
G
R
I
ID
S
S
S
R
L
VI
TS
--
-
-
-
-
---
-
--
--------
D
E
GVR
AG
R
S
I
P
L
KKN
VD
D
AL
KN
P
N
VT
SV
E
HVVV
LK
R
TGGKIDWQEGRDLWWHDLV
E
Q
A
SA
Q
HQ
A
EEM
N
A
E
D
P
L
F
IL
Y
TSG
S
TG
K
PKGVL
H
T
T
G
G
Y
L
----V
Y
A
A
-
L
TFK
YV
FDYHPG
D
I
Y
WCT
A
D
V
G
W
V
TG
HSYLLY
G
P
L
AC
GAT
T
LM
F
E
GV
PNWP
TP
A
R
MAQV
VDK
H
Q
V
N
----
I
L
YTA
P
TA
IR
A
LM
A
EG
DK
A
IEGTD
R
-
S
S
LR
I
L
G
----
SVGEP
IN
P
E
AWEWY
W
KK
I
G
N
E
KCPVV
DT
WW
Q
TET
GGFM
I
T
P
L
--
-
-
PG
AT
E
LKA
G
S
A
T
R
P
F
FGV
Q
PA
LVD
N
EGN
PL
E
G
A
T
EG
S
LV
I
TD
S
WPG
Q
A
R
TLF
GDHERFE
QT
YF
--
-
-S
T
F
K
N
M
---
--
YFSGD
GA
RRDE
D
GY
YW
ITGR
VD
DV
L
N
VS
G
HR
L
G
TA
EIES
A
L
VA
HPKI
A
E
A
A
VVGIP
H
N
I
K
G
Q
AI
Y
AYV
T
LN
H
-
GE
E
P
S
P
E
L
Y
AE
VR
N
W
V
RK
E
I
GP
L
A
T
P
DV
L
HWT
D
S
LP
K
T
R
SGKI
MRRI
LR
fig|199310.4.peg.4750
Escherichia coli CFT073 (90-616/652)
GD
R
TAII
W
E
G
DD
AS
QSKH
I
SY
K
ELH
RDVC
R
F
AN
TL
L
E
LGIKKGD
V
VA
IY
M
P
MV
PE
A
A
V
AM
LACA
R
IGAV
H
SV
I
FGGFSP
E
A
V
A
G
R
I
ID
S
S
S
R
L
VI
TS
--
-
-
-
-
---
-
--
--------
D
E
GVR
AG
R
S
I
P
L
KKN
VD
D
AL
KN
P
N
VT
SV
E
HVVV
LK
R
TGGKIDWQEGRDLWWHDLV
E
Q
A
SA
Q
HQ
A
EEM
N
A
E
D
P
L
F
IL
Y
TSG
S
TG
K
PKGVL
H
T
T
G
G
Y
L
----V
Y
A
A
-
L
TFK
YV
FDYHPG
D
I
Y
WCT
A
D
V
G
W
V
TG
HSYLLY
G
P
L
AC
GAT
T
LM
F
E
GV
PNWP
TP
A
R
MAQV
VDK
H
Q
V
N
----
I
L
YTA
P
TA
IR
A
LM
A
EG
DK
A
IEGTD
R
-
S
S
LR
I
L
G
----
SVGEP
IN
P
E
AWEWY
W
KK
I
G
N
E
KCPVV
DT
WW
Q
TET
GGFM
I
T
P
L
--
-
-
PG
AT
E
LKA
G
S
A
T
R
P
F
FGV
Q
PA
LVD
N
EGN
PL
E
G
A
T
EG
S
LV
I
TD
S
WPG
Q
A
R
TLF
GDHERFE
QT
YF
--
-
-S
T
F
K
N
M
---
--
YFSGD
GA
RRDE
D
GY
YW
ITGR
VD
DV
L
N
VS
G
HR
L
G
TA
EIES
A
L
VA
HPKI
A
E
A
A
VVGIP
H
N
I
K
G
Q
AI
Y
AYV
T
LN
H
-
GE
E
P
S
P
E
L
Y
AE
VR
N
W
V
RK
E
I
GP
L
A
T
P
DV
L
HWT
D
S
LP
K
T
R
SGKI
MRRI
LR
fig|585397.7.peg.4781
Escherichia coli ED1a (90-616/652)
GD
R
TAII
W
E
G
DD
AS
QSKH
I
SY
K
ELH
RDVC
R
F
AN
TL
L
E
LGIKKGD
V
VA
IY
M
P
MV
PE
A
A
V
AM
LACA
R
IGAV
H
SV
I
FGGFSP
E
A
V
A
G
R
I
ID
S
S
S
R
L
VI
TS
--
-
-
-
-
---
-
--
--------
D
E
GVR
AG
R
S
I
P
L
KKN
VD
D
AL
KN
P
N
VT
SV
E
HVVV
LK
R
TGGKIDWQEGRDLWWHDLV
E
Q
A
SA
Q
HQ
A
EEM
N
A
E
D
P
L
F
IL
Y
TSG
S
TG
K
PKGVL
H
T
T
G
G
Y
L
----V
Y
A
A
-
L
TFK
YV
FDYHPG
D
I
Y
WCT
A
D
V
G
W
V
TG
HSYLLY
G
P
L
AC
GAT
T
LM
F
E
GV
PNWP
TP
A
R
MAQV
VDK
H
Q
V
N
----
I
L
YTA
P
TA
IR
A
LM
A
EG
DK
A
IEGTD
R
-
S
S
LR
I
L
G
----
SVGEP
IN
P
E
AWEWY
W
KK
I
G
N
E
KCPVV
DT
WW
Q
TET
GGFM
I
T
P
L
--
-
-
PG
AT
E
LKA
G
S
A
T
R
P
F
FGV
Q
PA
LVD
N
EGN
PL
E
G
A
T
EG
S
LV
I
TD
S
WPG
Q
A
R
TLF
GDHERFE
QT
YF
--
-
-S
T
F
K
N
M
---
--
YFSGD
GA
RRDE
D
GY
YW
ITGR
VD
DV
L
N
VS
G
HR
L
G
TA
EIES
A
L
VA
HPKI
A
E
A
A
VVGIP
H
N
I
K
G
Q
AI
Y
AYV
T
LN
H
-
GE
E
P
S
P
E
L
Y
AE
VR
N
W
V
RK
E
I
GP
L
A
T
P
DV
L
HWT
D
S
LP
K
T
R
SGKI
MRRI
LR
fig|585397.9.peg.4781
Escherichia coli ED1a (90-616/652)
GD
R
TAII
W
E
G
DD
AS
QSKH
I
SY
K
ELH
RDVC
R
F
AN
TL
L
E
LGIKKGD
V
VA
IY
M
P
MV
PE
A
A
V
AM
LACA
R
IGAV
H
SV
I
FGGFSP
E
A
V
A
G
R
I
ID
S
S
S
R
L
VI
TS
--
-
-
-
-
---
-
--
--------
D
E
GVR
AG
R
S
I
P
L
KKN
VD
D
AL
KN
P
N
VT
SV
E
HVVV
LK
R
TGGKIDWQEGRDLWWHDLV
E
Q
A
SA
Q
HQ
A
EEM
N
A
E
D
P
L
F
IL
Y
TSG
S
TG
K
PKGVL
H
T
T
G
G
Y
L
----V
Y
A
A
-
L
TFK
YV
FDYHPG
D
I
Y
WCT
A
D
V
G
W
V
TG
HSYLLY
G
P
L
AC
GAT
T
LM
F
E
GV
PNWP
TP
A
R
MAQV
VDK
H
Q
V
N
----
I
L
YTA
P
TA
IR
A
LM
A
EG
DK
A
IEGTD
R
-
S
S
LR
I
L
G
----
SVGEP
IN
P
E
AWEWY
W
KK
I
G
N
E
KCPVV
DT
WW
Q
TET
GGFM
I
T
P
L
--
-
-
PG
AT
E
LKA
G
S
A
T
R
P
F
FGV
Q
PA
LVD
N
EGN
PL
E
G
A
T
EG
S
LV
I
TD
S
WPG
Q
A
R
TLF
GDHERFE
QT
YF
--
-
-S
T
F
K
N
M
---
--
YFSGD
GA
RRDE
D
GY
YW
ITGR
VD
DV
L
N
VS
G
HR
L
G
TA
EIES
A
L
VA
HPKI
A
E
A
A
VVGIP
H
N
I
K
G
Q
AI
Y
AYV
T
LN
H
-
GE
E
P
S
P
E
L
Y
AE
VR
N
W
V
RK
E
I
GP
L
A
T
P
DV
L
HWT
D
S
LP
K
T
R
SGKI
MRRI
LR
fig|340197.3.peg.2085
Escherichia coli F11 (90-616/652)
GD
R
TAII
W
E
G
DD
AS
QSKH
I
SY
K
ELH
RDVC
R
F
AN
TL
L
E
LGIKKGD
V
VA
IY
M
P
MV
PE
A
A
V
AM
LACA
R
IGAV
H
SV
I
FGGFSP
E
A
V
A
G
R
I
ID
S
S
S
R
L
VI
TS
--
-
-
-
-
---
-
--
--------
D
E
GVR
AG
R
S
I
P
L
KKN
VD
D
AL
KN
P
N
VT
SV
E
HVVV
LK
R
TGGKIDWQEGRDLWWHDLV
E
Q
A
SA
Q
HQ
A
EEM
N
A
E
D
P
L
F
IL
Y
TSG
S
TG
K
PKGVL
H
T
T
G
G
Y
L
----V
Y
A
A
-
L
TFK
YV
FDYHPG
D
I
Y
WCT
A
D
V
G
W
V
TG
HSYLLY
G
P
L
AC
GAT
T
LM
F
E
GV
PNWP
TP
A
R
MAQV
VDK
H
Q
V
N
----
I
L
YTA
P
TA
IR
A
LM
A
EG
DK
A
IEGTD
R
-
S
S
LR
I
L
G
----
SVGEP
IN
P
E
AWEWY
W
KK
I
G
N
E
KCPVV
DT
WW
Q
TET
GGFM
I
T
P
L
--
-
-
PG
AT
E
LKA
G
S
A
T
R
P
F
FGV
Q
PA
LVD
N
EGN
PL
E
G
A
T
EG
S
LV
I
TD
S
WPG
Q
A
R
TLF
GDHERFE
QT
YF
--
-
-S
T
F
K
N
M
---
--
YFSGD
GA
RRDE
D
GY
YW
ITGR
VD
DV
L
N
VS
G
HR
L
G
TA
EIES
A
L
VA
HPKI
A
E
A
A
VVGIP
H
N
I
K
G
Q
AI
Y
AYV
T
LN
H
-
GE
E
P
S
P
E
L
Y
AE
VR
N
W
V
RK
E
I
GP
L
A
T
P
DV
L
HWT
D
S
LP
K
T
R
SGKI
MRRI
LR
fig|340197.5.peg.2198
Escherichia coli F11 (90-616/652)
GD
R
TAII
W
E
G
DD
AS
QSKH
I
SY
K
ELH
RDVC
R
F
AN
TL
L
E
LGIKKGD
V
VA
IY
M
P
MV
PE
A
A
V
AM
LACA
R
IGAV
H
SV
I
FGGFSP
E
A
V
A
G
R
I
ID
S
S
S
R
L
VI
TS
--
-
-
-
-
---
-
--
--------
D
E
GVR
AG
R
S
I
P
L
KKN
VD
D
AL
KN
P
N
VT
SV
E
HVVV
LK
R
TGGKIDWQEGRDLWWHDLV
E
Q
A
SA
Q
HQ
A
EEM
N
A
E
D
P
L
F
IL
Y
TSG
S
TG
K
PKGVL
H
T
T
G
G
Y
L
----V
Y
A
A
-
L
TFK
YV
FDYHPG
D
I
Y
WCT
A
D
V
G
W
V
TG
HSYLLY
G
P
L
AC
GAT
T
LM
F
E
GV
PNWP
TP
A
R
MAQV
VDK
H
Q
V
N
----
I
L
YTA
P
TA
IR
A
LM
A
EG
DK
A
IEGTD
R
-
S
S
LR
I
L
G
----
SVGEP
IN
P
E
AWEWY
W
KK
I
G
N
E
KCPVV
DT
WW
Q
TET
GGFM
I
T
P
L
--
-
-
PG
AT
E
LKA
G
S
A
T
R
P
F
FGV
Q
PA
LVD
N
EGN
PL
E
G
A
T
EG
S
LV
I
TD
S
WPG
Q
A
R
TLF
GDHERFE
QT
YF
--
-
-S
T
F
K
N
M
---
--
YFSGD
GA
RRDE
D
GY
YW
ITGR
VD
DV
L
N
VS
G
HR
L
G
TA
EIES
A
L
VA
HPKI
A
E
A
A
VVGIP
H
N
I
K
G
Q
AI
Y
AYV
T
LN
H
-
GE
E
P
S
P
E
L
Y
AE
VR
N
W
V
RK
E
I
GP
L
A
T
P
DV
L
HWT
D
S
LP
K
T
R
SGKI
MRRI
LR
fig|656393.3.peg.178
Escherichia coli H299 (90-616/652)
GD
R
TAII
W
E
G
DD
AS
QSKH
I
SY
K
ELH
RDVC
R
F
AN
TL
L
E
LGIKKGD
V
VA
IY
M
P
MV
PE
A
A
V
AM
LACA
R
IGAV
H
SV
I
FGGFSP
E
A
V
A
G
R
I
ID
S
NS
R
L
VI
TS
--
-
-
-
-
---
-
--
--------
D
E
GVR
AG
R
S
I
P
L
KKN
VD
D
AL
KN
P
N
VT
S
I
E
HVVV
LK
R
TGGKIDWQEGRDLWWHDLV
E
Q
A
SD
Q
HQ
A
EEM
N
A
E
D
P
L
F
IL
Y
TSG
S
TG
K
PKGVL
H
T
T
G
G
Y
L
----V
Y
A
A
-
L
TFK
YV
FDYHPG
D
I
Y
WCT
A
D
V
G
W
V
TG
HSYLLY
G
P
L
AC
GAT
T
LM
F
E
GV
PNWP
TP
A
R
MAQV
VDK
H
Q
V
N
----
I
L
YTA
P
TA
IR
A
LM
A
EG
DK
A
IEGTD
R
-
S
S
LR
I
L
G
----
SVGEP
IN
P
E
AWEWY
W
KK
I
G
N
E
KCPVV
DT
WW
Q
TET
GGFM
I
T
P
L
--
-
-
PG
AT
E
LKA
G
S
A
T
R
P
F
FGV
Q
PA
LVD
N
EGH
PL
E
G
A
T
EG
S
LV
I
TD
S
WPG
Q
A
R
TLF
GDHERFE
QT
YF
--
-
-S
T
F
K
N
M
---
--
YFSGD
GA
RRDE
D
GY
YW
ITGR
VD
DV
L
N
VS
G
HR
L
G
TA
EIES
A
L
VA
HPKI
A
E
A
A
VVGIP
H
N
I
K
G
Q
AI
Y
AYV
T
LN
H
-
GE
E
P
S
P
E
L
Y
AE
VR
N
W
V
RK
E
I
GP
L
A
T
P
DV
L
HWT
D
S
LP
K
T
R
SGKI
MRRI
LR
fig|749546.3.peg.5036
Escherichia coli MS 185-1 (90-616/653)
GD
R
TAII
W
E
G
DD
AS
QSKH
I
SY
K
ELH
RDVC
R
F
AN
TL
L
E
LGIKKGD
V
VA
IY
M
P
MV
PE
A
A
V
AM
LACA
R
IGAV
H
SV
I
FGGFSP
E
A
V
A
G
R
I
ID
S
S
S
R
L
VI
TS
--
-
-
-
-
---
-
--
--------
D
E
GVR
AG
R
S
I
P
L
KKN
VD
D
AL
KN
P
N
VT
SV
E
HVVV
LK
R
TGGKIDWQEGRDLWWHDLV
E
Q
A
SA
Q
HQ
A
EEM
N
A
E
D
P
L
F
IL
Y
TSG
S
TG
K
PKGVL
H
T
T
G
G
Y
L
----V
Y
A
A
-
L
TFK
YV
FDYHPG
D
I
Y
WCT
A
D
V
G
W
V
TG
HSYLLY
G
P
L
AC
GAT
T
LM
F
E
GV
PNWP
TP
A
R
MAQV
VDK
H
Q
V
N
----
I
L
YTA
P
TA
IR
A
LM
A
EG
DK
A
IEGTD
R
-
S
S
LR
I
L
G
----
SVGEP
IN
P
E
AWEWY
W
KK
I
G
N
E
KCPVV
DT
WW
Q
TET
GGFM
I
T
P
L
--
-
-
PG
AT
E
LKA
G
S
A
T
R
P
F
FGV
Q
PA
LVD
N
EGN
PL
E
G
A
T
EG
S
LV
I
TD
S
WPG
Q
A
R
TLF
GDHERFE
QT
YF
--
-
-S
T
F
K
N
M
---
--
YFSGD
GA
RRDE
D
GY
YW
ITGR
VD
DV
L
N
VS
G
HR
L
G
TA
EIES
A
L
VA
HPKI
A
E
A
A
VVGIP
H
N
I
K
G
Q
AI
Y
AYV
T
LN
H
-
GE
E
P
S
P
E
L
Y
AE
VR
N
W
V
RK
E
I
GP
L
A
T
P
DV
L
HWT
D
S
LP
K
T
R
SGKI
MRRI
LR
fig|749550.3.peg.1425
Escherichia coli MS 200-1 (90-616/652)
GD
R
TAII
W
E
G
DD
AS
QSKH
I
SY
K
ELH
RDVC
R
F
AN
TL
L
E
LGIKKGD
V
VA
IY
M
P
MV
PE
A
A
V
AM
LACA
R
IGAV
H
SV
I
FGGFSP
E
A
V
A
G
R
I
ID
S
S
S
R
L
VI
TS
--
-
-
-
-
---
-
--
--------
D
E
GVR
AG
R
S
I
P
L
KKN
VD
D
AL
KN
P
N
VT
SV
E
HVVV
LK
R
TGGKIDWQEGRDLWWHDLV
E
Q
A
SA
Q
HQ
A
EEM
N
A
E
D
P
L
F
IL
Y
TSG
S
TG
K
PKGVL
H
T
T
G
G
Y
L
----V
Y
A
A
-
L
TFK
YV
FDYHPG
D
I
Y
WCT
A
D
V
G
W
V
TG
HSYLLY
G
P
L
AC
GAT
T
LM
F
E
GV
PNWP
TP
A
R
MAQV
VDK
H
Q
V
N
----
I
L
YTA
P
TA
IR
A
LM
A
EG
DK
A
IEGTD
R
-
S
S
LR
I
L
G
----
SVGEP
IN
P
E
AWEWY
W
KK
I
G
N
E
KCPVV
DT
WW
Q
TET
GGFM
I
T
P
L
--
-
-
PG
AT
E
LKA
G
S
A
T
R
P
F
FGV
Q
PA
LVD
N
EGN
PL
E
G
A
T
EG
S
LV
I
TD
S
WPG
Q
A
R
TLF
GDHERFE
QT
YF
--
-
-S
T
F
K
N
M
---
--
YFSGD
GA
RRDE
D
GY
YW
ITGR
VD
DV
L
N
VS
G
HR
L
G
TA
EIES
A
L
VA
HPKI
A
E
A
A
VVGIP
H
N
I
K
G
Q
AI
Y
AYV
T
LN
H
-
GE
E
P
S
P
E
L
Y
AE
VR
N
W
V
RK
E
I
GP
L
A
T
P
DV
L
HWT
D
S
LP
K
T
R
SGKI
MRRI
LR
fig|749528.3.peg.631
Escherichia coli MS 45-1 (90-616/652)
GD
R
TAII
W
E
G
DD
AS
QSKH
I
SY
K
ELH
RDVC
R
F
AN
TL
L
E
LGIKKGD
V
VA
IY
M
P
MV
PE
A
A
V
AM
LACA
R
IGAV
H
SV
I
FGGFSP
E
A
V
A
G
R
I
ID
S
S
S
R
L
VI
TS
--
-
-
-
-
---
-
--
--------
D
E
GVR
AG
R
S
I
P
L
KKN
VD
D
AL
KN
P
N
VT
SV
E
HVVV
LK
R
TGGKIDWQEGRDLWWHDLV
E
Q
A
SA
Q
HQ
A
EEM
N
A
E
D
P
L
F
IL
Y
TSG
S
TG
K
PKGVL
H
T
T
G
G
Y
L
----V
Y
A
A
-
L
TFK
YV
FDYHPG
D
I
Y
WCT
A
D
V
G
W
V
TG
HSYLLY
G
P
L
AC
GAT
T
LM
F
E
GV
PNWP
TP
A
R
MAQV
VDK
H
Q
V
N
----
I
L
YTA
P
TA
IR
A
LM
A
EG
DK
A
IEGTD
R
-
S
S
LR
I
L
G
----
SVGEP
IN
P
E
AWEWY
W
KK
I
G
N
E
KCPVV
DT
WW
Q
TET
GGFM
I
T
P
L
--
-
-
PG
AT
E
LKA
G
S
A
T
R
P
F
FGV
Q
PA
LVD
N
EGN
PL
E
G
A
T
EG
S
LV
I
TD
S
WPG
Q
A
R
TLF
GDHERFE
QT
YF
--
-
-S
T
F
K
N
M
---
--
YFSGD
GA
RRDE
D
GY
YW
ITGR
VD
DV
L
N
VS
G
HR
L
G
TA
EIES
A
L
VA
HPKI
A
E
A
A
VVGIP
H
N
I
K
G
Q
AI
Y
AYV
T
LN
H
-
GE
E
P
S
P
E
L
Y
AE
VR
N
W
V
RK
E
I
GP
L
A
T
P
DV
L
HWT
D
S
LP
K
T
R
SGKI
MRRI
LR
fig|656440.3.peg.4645
Escherichia coli TA206 (90-616/652)
GD
R
TAII
W
E
G
DD
AS
QSKH
I
SY
K
ELH
RDVC
R
F
AN
TL
L
E
LGIKKGD
V
VA
IY
M
P
MV
PE
A
A
V
AM
LACA
R
IGAV
H
SV
I
FGGFSP
E
A
V
A
G
R
I
ID
S
S
S
R
L
VI
TS
--
-
-
-
-
---
-
--
--------
D
E
GVR
AG
R
S
I
P
L
KKN
VD
D
AL
KN
P
N
VT
SV
E
HVVV
LK
R
TGGKIDWQEGRDLWWHDLV
E
Q
A
SA
Q
HQ
A
EEM
N
A
E
D
P
L
F
IL
Y
TSG
S
TG
K
PKGVL
H
T
T
G
G
Y
L
----V
Y
A
A
-
L
TFK
YV
FDYHPG
D
I
Y
WCT
A
D
V
G
W
V
TG
HSYLLY
G
P
L
AC
GAT
T
LM
F
E
GV
PNWP
TP
A
R
MAQV
VDK
H
Q
V
N
----
I
L
YTA
P
TA
IR
A
LM
A
EG
DK
A
IEGTD
R
-
S
S
LR
I
L
G
----
SVGEP
IN
P
E
AWEWY
W
KK
I
G
N
E
KCPVV
DT
WW
Q
TET
GGFM
I
T
P
L
--
-
-
PG
AT
E
LKA
G
S
A
T
R
P
F
FGV
Q
PA
LVD
N
EGN
PL
E
G
A
T
EG
S
LV
I
TD
S
WPG
Q
A
R
TLF
GDHERFE
QT
YF
--
-
-S
T
F
K
N
M
---
--
YFSGD
GA
RRDE
D
GY
YW
ITGR
VD
DV
L
N
VS
G
HR
L
G
TA
EIES
A
L
VA
HPKI
A
E
A
A
VVGIP
H
N
I
K
G
Q
AI
Y
AYV
T
LN
H
-
GE
E
P
S
P
E
L
Y
AE
VR
N
W
V
RK
E
I
GP
L
A
T
P
DV
L
HWT
D
S
LP
K
T
R
SGKI
MRRI
LR
fig|562.376.peg.1730
Escherichia coli WV_060327 (90-616/652)
GD
R
TAII
W
E
G
DD
AS
QSKH
I
SY
K
ELH
RDVC
R
F
AN
TL
L
E
LGIKKGD
V
VA
IY
M
P
MV
PE
A
A
V
AM
LACA
R
IGAV
H
SV
I
FGGFSP
E
A
V
A
G
R
I
ID
S
S
S
R
L
VI
TS
--
-
-
-
-
---
-
--
--------
D
E
GVR
AG
R
S
I
P
L
KKN
VD
D
AL
KN
P
N
VT
SV
E
HVVV
LK
R
TGGKIDWQEGRDLWWHDLV
E
Q
A
SA
Q
HQ
A
EEM
N
A
E
D
P
L
F
IL
Y
TSG
S
TG
K
PKGVL
H
T
T
G
G
Y
L
----V
Y
A
A
-
L
TFK
YV
FDYHPG
D
I
Y
WCT
A
D
V
G
W
V
TG
HSYLLY
G
P
L
AC
GAT
T
LM
F
E
GV
PNWP
TP
A
R
MAQV
VDK
H
Q
V
N
----
I
L
YTA
P
TA
IR
A
LM
A
EG
DK
A
IEGTD
R
-
S
S
LR
I
L
G
----
SVGEP
IN
P
E
AWEWY
W
KK
I
G
N
E
KCPVV
DT
WW
Q
TET
GGFM
I
T
P
L
--
-
-
PG
AT
E
LKA
G
S
A
T
R
P
F
FGV
Q
PA
LVD
N
EGN
PL
E
G
A
T
EG
S
LV
I
TD
S
WPG
Q
A
R
TLF
GDHERFE
QT
YF
--
-
-S
T
F
K
N
M
---
--
YFSGD
GA
RRDE
D
GY
YW
ITGR
VD
DV
L
N
VS
G
HR
L
G
TA
EIES
A
L
VA
HPKI
A
E
A
A
VVGIP
H
N
I
K
G
Q
AI
Y
AYV
T
LN
H
-
GE
E
P
S
P
E
L
Y
AE
VR
N
W
V
RK
E
I
GP
L
A
T
P
DV
L
HWT
D
S
LP
K
T
R
SGKI
MRRI
LR
fig|216592.1.peg.2366
Escherichia coli 042 (90-616/652)
GD
R
TAII
W
E
G
DD
AS
QSKH
I
SY
K
ELH
RDVC
R
F
AN
TL
L
E
LGIKKGD
V
VA
IY
M
P
MV
PE
A
A
V
AM
LACA
R
IGAV
H
SV
I
FGGFSP
E
A
V
A
G
R
I
ID
S
NS
R
L
VI
TS
--
-
-
-
-
---
-
--
--------
D
E
GVR
AG
R
S
I
P
L
KKN
VD
D
AL
KN
P
N
VT
S
I
E
HVVV
LK
R
TGGKIDWQEGRDLWWHDL
I
E
Q
A
SD
Q
HQ
A
EEM
N
A
E
D
P
L
F
IL
Y
TSG
S
TG
K
PKGVL
H
T
T
G
G
Y
L
----V
Y
A
A
-
L
TFK
YV
FDYHPG
D
I
Y
WCT
A
D
V
G
W
V
TG
HSYLLY
G
P
L
AC
GAT
T
LM
F
E
GV
PNWP
TP
A
R
MAQV
VDK
H
Q
V
N
----
I
L
YTA
P
TA
IR
A
LM
A
EG
DK
A
IEGTD
R
-
S
S
LR
I
L
G
----
SVGEP
IN
P
E
AWEWY
W
KK
I
G
N
E
KCPVV
DT
WW
Q
TET
GGFM
I
T
P
L
--
-
-
PG
AT
E
LKA
G
S
A
T
R
P
F
FGV
Q
PA
LVD
N
EGN
PL
E
G
A
T
EG
S
LV
I
TD
S
WPG
Q
A
R
TLF
GDHERFE
QT
YF
--
-
-S
T
F
K
N
M
---
--
YFSGD
GA
RRDE
D
GY
YW
ITGR
VD
DV
L
N
VS
G
HR
L
G
TA
EIES
A
L
VA
HPKI
A
E
A
A
VVGIP
H
N
I
K
G
Q
AI
Y
AYV
T
LN
H
-
GE
E
P
S
P
E
L
Y
AE
VR
N
W
V
RK
E
I
GP
L
A
T
P
DV
L
HWT
D
S
LP
K
T
R
SGKI
MRRI
LR
fig|216592.3.peg.4610
Escherichia coli 042 (90-616/652)
GD
R
TAII
W
E
G
DD
AS
QSKH
I
SY
K
ELH
RDVC
R
F
AN
TL
L
E
LGIKKGD
V
VA
IY
M
P
MV
PE
A
A
V
AM
LACA
R
IGAV
H
SV
I
FGGFSP
E
A
V
A
G
R
I
ID
S
NS
R
L
VI
TS
--
-
-
-
-
---
-
--
--------
D
E
GVR
AG
R
S
I
P
L
KKN
VD
D
AL
KN
P
N
VT
S
I
E
HVVV
LK
R
TGGKIDWQEGRDLWWHDL
I
E
Q
A
SD
Q
HQ
A
EEM
N
A
E
D
P
L
F
IL
Y
TSG
S
TG
K
PKGVL
H
T
T
G
G
Y
L
----V
Y
A
A
-
L
TFK
YV
FDYHPG
D
I
Y
WCT
A
D
V
G
W
V
TG
HSYLLY
G
P
L
AC
GAT
T
LM
F
E
GV
PNWP
TP
A
R
MAQV
VDK
H
Q
V
N
----
I
L
YTA
P
TA
IR
A
LM
A
EG
DK
A
IEGTD
R
-
S
S
LR
I
L
G
----
SVGEP
IN
P
E
AWEWY
W
KK
I
G
N
E
KCPVV
DT
WW
Q
TET
GGFM
I
T
P
L
--
-
-
PG
AT
E
LKA
G
S
A
T
R
P
F
FGV
Q
PA
LVD
N
EGN
PL
E
G
A
T
EG
S
LV
I
TD
S
WPG
Q
A
R
TLF
GDHERFE
QT
YF
--
-
-S
T
F
K
N
M
---
--
YFSGD
GA
RRDE
D
GY
YW
ITGR
VD
DV
L
N
VS
G
HR
L
G
TA
EIES
A
L
VA
HPKI
A
E
A
A
VVGIP
H
N
I
K
G
Q
AI
Y
AYV
T
LN
H
-
GE
E
P
S
P
E
L
Y
AE
VR
N
W
V
RK
E
I
GP
L
A
T
P
DV
L
HWT
D
S
LP
K
T
R
SGKI
MRRI
LR
fig|550677.3.peg.69
Escherichia coli B354 (90-616/652)
GD
R
TAII
W
E
G
DD
AS
QSKH
I
SY
K
ELH
RDVC
R
F
AN
TL
L
E
LGIKKGD
V
VA
IY
M
P
MV
PE
A
A
V
AM
LACA
R
IGAV
H
SV
I
FGGFSP
E
A
V
A
G
R
I
ID
S
NS
R
L
VI
TS
--
-
-
-
-
---
-
--
--------
D
E
GVR
AG
R
S
I
P
L
KKN
VD
D
AL
KN
P
N
VT
S
I
E
HVVV
LK
R
TGGKIDWQEGRDLWWHDL
I
E
Q
A
SD
Q
HQ
A
EEM
N
A
E
D
P
L
F
IL
Y
TSG
S
TG
K
PKGVL
H
T
T
G
G
Y
L
----V
Y
A
A
-
L
TFK
YV
FDYHPG
D
I
Y
WCT
A
D
V
G
W
V
TG
HSYLLY
G
P
L
AC
GAT
T
LM
F
E
GV
PNWP
TP
A
R
MAQV
VDK
H
Q
V
N
----
I
L
YTA
P
TA
IR
A
LM
A
EG
DK
A
IEGTD
R
-
S
S
LR
I
L
G
----
SVGEP
IN
P
E
AWEWY
W
KK
I
G
N
E
KCPVV
DT
WW
Q
TET
GGFM
I
T
P
L
--
-
-
PG
AT
E
LKA
G
S
A
T
R
P
F
FGV
Q
PA
LVD
N
EGN
PL
E
G
A
T
EG
S
LV
I
TD
S
WPG
Q
A
R
TLF
GDHERFE
QT
YF
--
-
-S
T
F
K
N
M
---
--
YFSGD
GA
RRDE
D
GY
YW
ITGR
VD
DV
L
N
VS
G
HR
L
G
TA
EIES
A
L
VA
HPKI
A
E
A
A
VVGIP
H
N
I
K
G
Q
AI
Y
AYV
T
LN
H
-
GE
E
P
S
P
E
L
Y
AE
VR
N
W
V
RK
E
I
GP
L
A
T
P
DV
L
HWT
D
S
LP
K
T
R
SGKI
MRRI
LR
fig|749531.3.peg.2334
Escherichia coli MS 69-1 (90-616/652)
GD
R
TAII
W
E
G
DD
AS
QSKH
I
SY
K
ELH
RDVC
R
F
AN
TL
L
E
LGIKKGD
V
VA
IY
M
P
MV
PE
A
A
V
AM
LACA
R
IGAV
H
SV
I
FGGFSP
E
A
V
A
G
R
I
ID
S
NS
R
L
VI
TS
--
-
-
-
-
---
-
--
--------
D
E
GVR
AG
R
S
I
P
L
KKN
VD
D
AL
KN
P
N
VT
S
I
E
HVVV
LK
R
TGGKIDWQEGRDLWWHDL
I
E
Q
A
SD
Q
HQ
A
EEM
N
A
E
D
P
L
F
IL
Y
TSG
S
TG
K
PKGVL
H
T
T
G
G
Y
L
----V
Y
A
A
-
L
TFK
YV
FDYHPG
D
I
Y
WCT
A
D
V
G
W
V
TG
HSYLLY
G
P
L
AC
GAT
T
LM
F
E
GV
PNWP
TP
A
R
MAQV
VDK
H
Q
V
N
----
I
L
YTA
P
TA
IR
A
LM
A
EG
DK
A
IEGTD
R
-
S
S
LR
I
L
G
----
SVGEP
IN
P
E
AWEWY
W
KK
I
G
N
E
KCPVV
DT
WW
Q
TET
GGFM
I
T
P
L
--
-
-
PG
AT
E
LKA
G
S
A
T
R
P
F
FGV
Q
PA
LVD
N
EGN
PL
E
G
A
T
EG
S
LV
I
TD
S
WPG
Q
A
R
TLF
GDHERFE
QT
YF
--
-
-S
T
F
K
N
M
---
--
YFSGD
GA
RRDE
D
GY
YW
ITGR
VD
DV
L
N
VS
G
HR
L
G
TA
EIES
A
L
VA
HPKI
A
E
A
A
VVGIP
H
N
I
K
G
Q
AI
Y
AYV
T
LN
H
-
GE
E
P
S
P
E
L
Y
AE
VR
N
W
V
RK
E
I
GP
L
A
T
P
DV
L
HWT
D
S
LP
K
T
R
SGKI
MRRI
LR
fig|439855.10.peg.4646
Escherichia coli SMS-3-5 (90-616/652)
GD
R
TAII
W
E
G
DD
AS
QSKH
I
SY
K
ELH
RDVC
R
F
AN
TL
L
E
LGIKKGD
V
VA
IY
M
P
MV
PE
A
A
V
AM
LACA
R
IGAV
H
SV
I
FGGFSP
E
A
V
A
G
R
I
ID
S
NS
R
L
VI
TS
--
-
-
-
-
---
-
--
--------
D
E
GVR
AG
R
S
I
P
L
KKN
VD
D
AL
KN
P
N
VT
SV
E
HVVV
LK
R
TGGKIDWQEGRDLWWHDLV
E
Q
A
SD
Q
HQ
A
EEM
N
A
E
D
P
L
F
IL
Y
TSG
S
TG
K
PKGVL
H
T
T
G
G
Y
L
----V
Y
A
A
-
L
TFK
YV
FDYHPG
D
I
Y
WCT
A
D
V
G
W
V
TG
HSYLLY
G
P
L
AC
GAT
T
LM
F
E
GV
PNWP
TP
A
R
MAQV
VDK
H
Q
V
N
----
I
L
YTA
P
TA
IR
A
LM
A
EG
DK
A
IEGTD
R
-
S
S
LR
I
L
G
----
SVGEP
IN
P
E
AWEWY
W
KK
I
G
N
E
KCPVV
DT
WW
Q
TET
GGFM
I
T
P
L
--
-
-
PG
AT
E
LKA
G
S
A
T
R
P
F
FGV
Q
PA
LVD
N
EGH
PL
E
G
A
A
EG
S
LV
I
TD
S
WPG
Q
A
R
TLF
GDHERFE
QT
YF
--
-
-S
T
F
K
N
M
---
--
YFSGD
GA
RRDE
D
GY
YW
ITGR
VD
DV
L
N
VS
G
HR
L
G
TA
EIES
A
L
VA
HPKI
A
E
A
A
VVGIP
H
N
I
K
G
Q
AI
Y
AYV
T
LN
H
-
GE
E
P
S
P
E
L
Y
AE
VR
N
W
V
RK
E
I
GP
L
A
T
P
DV
L
HWT
D
S
LP
K
T
R
SGKI
MRRI
LR
fig|749527.3.peg.2929
Escherichia coli MS 21-1 (90-616/652)
GD
R
TAII
W
E
G
DD
AS
QSKH
I
SY
K
ELH
RDVC
R
F
AN
TL
L
E
LGIKKGD
V
VA
IY
M
P
MV
PE
A
A
V
AM
LACA
R
IGAV
H
SV
I
FGGFSP
E
A
V
A
G
R
I
ID
S
S
S
R
L
VI
TS
--
-
-
-
-
---
-
--
--------
D
E
GVR
AG
R
S
I
P
L
KKN
VD
D
AL
KN
P
N
VT
SV
E
HVVV
LK
R
TGGKIDWQEGRDLWWHDLV
E
Q
A
SD
Q
HQ
A
EEM
N
A
E
D
P
L
F
IL
Y
TSG
S
TG
K
PKGVL
H
T
T
G
G
Y
L
----V
Y
A
A
-
L
TFK
YV
FDYHPG
D
I
Y
WCT
A
D
V
G
W
V
TG
HSYLLY
G
P
L
AC
GAT
T
LM
F
E
GV
PNWP
TP
A
R
MAQV
VDK
H
Q
V
N
----
I
L
YTA
P
TA
IR
A
LM
A
EG
DK
A
IEGTD
R
-
S
S
LR
I
L
G
----
SVGEP
IN
P
E
AWEWY
W
KK
I
G
N
E
KCPVV
DT
WW
Q
TET
GGFM
I
T
P
L
--
-
-
PG
AT
E
LKA
G
S
A
T
R
P
F
FGV
Q
PA
LVD
N
EGH
PL
E
G
A
T
EG
S
LV
I
TD
S
WPG
Q
A
R
TLF
GDHERFE
QT
YF
--
-
-S
T
F
K
N
M
---
--
YFSGD
GA
RRDE
D
GY
YW
ITGR
VD
DV
L
N
VS
G
HR
L
G
TA
EIES
A
L
VA
HPKI
A
E
A
A
VVGIP
H
N
I
K
G
Q
AI
Y
AYV
T
LN
H
-
GE
E
P
S
P
E
L
Y
AE
VR
N
W
V
RK
E
I
GP
L
A
T
P
DV
L
HWT
D
S
LP
K
T
R
SGKI
MRRI
LR
fig|1040638.4.peg.1115
Escherichia coli O104:H4 str. LB226692 (90-616/652)
GD
R
TAII
W
E
G
DD
AS
QSKH
I
SY
K
ELH
RDVC
R
F
AN
TL
L
E
LGIKKGD
V
VA
IY
M
P
MV
PE
A
A
V
AM
LACA
R
IGAV
H
SV
I
FGGFSP
E
A
V
A
G
R
I
ID
S
NS
R
L
VI
TS
--
-
-
-
-
---
-
--
--------
D
E
GVR
AG
R
S
I
P
L
KKN
VD
D
AL
KN
P
N
VT
SV
E
HVVV
LK
R
TGGKIDWQEGRDLWWHDLV
E
Q
A
SD
Q
HQ
A
EEM
N
A
E
D
P
L
F
IL
Y
TSG
S
TG
K
PKGVL
H
T
T
G
G
Y
L
----V
Y
A
A
-
L
TFK
YV
FDYHPG
D
I
Y
WCT
A
D
V
G
W
V
TG
HSYLLY
G
P
L
AC
GAT
T
LM
F
E
GV
PNWP
TP
A
R
MAQV
VDK
H
Q
V
N
----
I
L
YTA
P
TA
IR
A
LM
A
EG
DK
A
IEGTD
R
-
S
S
LR
I
L
G
----
SVGEP
IN
P
E
AWEWY
W
KK
I
G
N
E
KCPVV
DT
WW
Q
TET
GGFM
I
T
P
L
--
-
-
PG
AT
E
LKA
G
S
A
T
R
P
F
FGV
Q
PA
LVD
N
EGN
PL
E
G
A
T
EG
S
LV
I
TD
S
WPG
Q
A
R
TLF
GDHERFE
QT
YF
--
-
-S
T
F
K
N
M
---
--
YFSGD
GA
RRDE
D
GY
YW
ITGR
VD
DV
L
N
VS
G
HR
L
G
TA
EIES
A
L
VA
HPKI
A
E
A
A
VVGIP
H
N
I
K
G
Q
AI
Y
AYV
T
LN
H
-
GE
E
P
S
P
E
L
Y
AE
VR
N
W
V
RK
E
I
GP
L
A
T
P
DV
L
HWT
D
S
LP
K
T
R
SGKI
MRRI
LR
fig|6666666.5357.peg.2298
Escherichia coli TY-2482 (90-616/652)
GD
R
TAII
W
E
G
DD
AS
QSKH
I
SY
K
ELH
RDVC
R
F
AN
TL
L
E
LGIKKGD
V
VA
IY
M
P
MV
PE
A
A
V
AM
LACA
R
IGAV
H
SV
I
FGGFSP
E
A
V
A
G
R
I
ID
S
NS
R
L
VI
TS
--
-
-
-
-
---
-
--
--------
D
E
GVR
AG
R
S
I
P
L
KKN
VD
D
AL
KN
P
N
VT
SV
E
HVVV
LK
R
TGGKIDWQEGRDLWWHDLV
E
Q
A
SD
Q
HQ
A
EEM
N
A
E
D
P
L
F
IL
Y
TSG
S
TG
K
PKGVL
H
T
T
G
G
Y
L
----V
Y
A
A
-
L
TFK
YV
FDYHPG
D
I
Y
WCT
A
D
V
G
W
V
TG
HSYLLY
G
P
L
AC
GAT
T
LM
F
E
GV
PNWP
TP
A
R
MAQV
VDK
H
Q
V
N
----
I
L
YTA
P
TA
IR
A
LM
A
EG
DK
A
IEGTD
R
-
S
S
LR
I
L
G
----
SVGEP
IN
P
E
AWEWY
W
KK
I
G
N
E
KCPVV
DT
WW
Q
TET
GGFM
I
T
P
L
--
-
-
PG
AT
E
LKA
G
S
A
T
R
P
F
FGV
Q
PA
LVD
N
EGN
PL
E
G
A
T
EG
S
LV
I
TD
S
WPG
Q
A
R
TLF
GDHERFE
QT
YF
--
-
-S
T
F
K
N
M
---
--
YFSGD
GA
RRDE
D
GY
YW
ITGR
VD
DV
L
N
VS
G
HR
L
G
TA
EIES
A
L
VA
HPKI
A
E
A
A
VVGIP
H
N
I
K
G
Q
AI
Y
AYV
T
LN
H
-
GE
E
P
S
P
E
L
Y
AE
VR
N
W
V
RK
E
I
GP
L
A
T
P
DV
L
HWT
D
S
LP
K
T
R
SGKI
MRRI
LR
fig|358709.5.peg.1815
Escherichia coli 101-1 (90-616/652)
GD
R
TAII
W
E
G
DD
AS
QSKH
I
SY
K
ELH
RDVC
R
F
AN
TL
L
E
LGIKKGD
V
VA
IY
M
P
MV
PE
A
A
V
AM
LACA
R
IGAV
H
SV
I
FGGFSP
E
A
V
A
G
R
I
ID
S
NS
R
L
VI
TS
--
-
-
-
-
---
-
--
--------
D
E
GVR
AG
R
S
I
P
L
KKN
VD
D
AL
KN
P
N
VT
SV
E
HVVV
LK
R
TGGKIDWQEGRDLWWHDLV
E
Q
A
SD
Q
HQ
A
EEM
N
A
E
D
P
L
F
IL
Y
TSG
S
TG
K
PKGVL
H
T
T
G
G
Y
L
----V
Y
A
A
-
L
TFK
YV
FDYHPG
D
I
Y
WCT
A
D
V
G
W
V
TG
HSYLLY
G
P
L
AC
GAT
T
LM
F
E
GV
PNWP
TP
A
R
MAQV
VDK
H
Q
V
N
----
I
L
YTA
P
TA
IR
A
LM
A
EG
DK
A
IEGTD
R
-
S
S
LR
I
L
G
----
SVGEP
IN
P
E
AWEWY
W
KK
I
G
N
E
KCPVV
DT
WW
Q
TET
GGFM
I
T
P
L
--
-
-
PG
AT
E
LKA
G
S
A
T
R
P
F
FGV
Q
PA
LVD
N
EGN
PL
E
G
A
T
EG
S
LV
I
TD
S
WPG
Q
A
R
TLF
GDHERFE
QT
YF
--
-
-S
T
F
K
N
M
---
--
YFSGD
GA
RRDE
D
GY
YW
ITGR
VD
DV
L
N
VS
G
HR
L
G
TA
EIES
A
L
VA
HPKI
A
E
A
A
VVGIP
H
N
I
K
G
Q
AI
Y
AYV
T
LN
H
-
GE
E
P
S
P
E
L
Y
AE
VR
N
W
V
RK
E
I
GP
L
A
T
P
DV
L
HWT
D
S
LP
K
T
R
SGKI
MRRI
LR
fig|670897.3.peg.1376
Escherichia coli 2362-75 (90-616/652)
GD
R
TAII
W
E
G
DD
AS
QSKH
I
SY
K
ELH
RDVC
R
F
AN
TL
L
E
LGIKKGD
V
VA
IY
M
P
MV
PE
A
A
V
AM
LACA
R
IGAV
H
SV
I
FGGFSP
E
A
V
A
G
R
I
ID
S
NS
R
L
VI
TS
--
-
-
-
-
---
-
--
--------
D
E
GVR
AG
R
S
I
P
L
KKN
VD
D
AL
KN
P
N
VT
SV
E
HVVV
LK
R
TGGKIDWQEGRDLWWHDLV
E
Q
A
SD
Q
HQ
A
EEM
N
A
E
D
P
L
F
IL
Y
TSG
S
TG
K
PKGVL
H
T
T
G
G
Y
L
----V
Y
A
A
-
L
TFK
YV
FDYHPG
D
I
Y
WCT
A
D
V
G
W
V
TG
HSYLLY
G
P
L
AC
GAT
T
LM
F
E
GV
PNWP
TP
A
R
MAQV
VDK
H
Q
V
N
----
I
L
YTA
P
TA
IR
A
LM
A
EG
DK
A
IEGTD
R
-
S
S
LR
I
L
G
----
SVGEP
IN
P
E
AWEWY
W
KK
I
G
N
E
KCPVV
DT
WW
Q
TET
GGFM
I
T
P
L
--
-
-
PG
AT
E
LKA
G
S
A
T
R
P
F
FGV
Q
PA
LVD
N
EGN
PL
E
G
A
T
EG
S
LV
I
TD
S
WPG
Q
A
R
TLF
GDHERFE
QT
YF
--
-
-S
T
F
K
N
M
---
--
YFSGD
GA
RRDE
D
GY
YW
ITGR
VD
DV
L
N
VS
G
HR
L
G
TA
EIES
A
L
VA
HPKI
A
E
A
A
VVGIP
H
N
I
K
G
Q
AI
Y
AYV
T
LN
H
-
GE
E
P
S
P
E
L
Y
AE
VR
N
W
V
RK
E
I
GP
L
A
T
P
DV
L
HWT
D
S
LP
K
T
R
SGKI
MRRI
LR
fig|344610.3.peg.1338
Escherichia coli 53638 (90-616/652)
GD
R
TAII
W
E
G
DD
AS
QSKH
I
SY
K
ELH
RDVC
R
F
AN
TL
L
E
LGIKKGD
V
VA
IY
M
P
MV
PE
A
A
V
AM
LACA
R
IGAV
H
SV
I
FGGFSP
E
A
V
A
G
R
I
ID
S
NS
R
L
VI
TS
--
-
-
-
-
---
-
--
--------
D
E
GVR
AG
R
S
I
P
L
KKN
VD
D
AL
KN
P
N
VT
SV
E
HVVV
LK
R
TGGKIDWQEGRDLWWHDLV
E
Q
A
SD
Q
HQ
A
EEM
N
A
E
D
P
L
F
IL
Y
TSG
S
TG
K
PKGVL
H
T
T
G
G
Y
L
----V
Y
A
A
-
L
TFK
YV
FDYHPG
D
I
Y
WCT
A
D
V
G
W
V
TG
HSYLLY
G
P
L
AC
GAT
T
LM
F
E
GV
PNWP
TP
A
R
MAQV
VDK
H
Q
V
N
----
I
L
YTA
P
TA
IR
A
LM
A
EG
DK
A
IEGTD
R
-
S
S
LR
I
L
G
----
SVGEP
IN
P
E
AWEWY
W
KK
I
G
N
E
KCPVV
DT
WW
Q
TET
GGFM
I
T
P
L
--
-
-
PG
AT
E
LKA
G
S
A
T
R
P
F
FGV
Q
PA
LVD
N
EGN
PL
E
G
A
T
EG
S
LV
I
TD
S
WPG
Q
A
R
TLF
GDHERFE
QT
YF
--
-
-S
T
F
K
N
M
---
--
YFSGD
GA
RRDE
D
GY
YW
ITGR
VD
DV
L
N
VS
G
HR
L
G
TA
EIES
A
L
VA
HPKI
A
E
A
A
VVGIP
H
N
I
K
G
Q
AI
Y
AYV
T
LN
H
-
GE
E
P
S
P
E
L
Y
AE
VR
N
W
V
RK
E
I
GP
L
A
T
P
DV
L
HWT
D
S
LP
K
T
R
SGKI
MRRI
LR
fig|344610.7.peg.2066
Escherichia coli 53638 (90-616/652)
GD
R
TAII
W
E
G
DD
AS
QSKH
I
SY
K
ELH
RDVC
R
F
AN
TL
L
E
LGIKKGD
V
VA
IY
M
P
MV
PE
A
A
V
AM
LACA
R
IGAV
H
SV
I
FGGFSP
E
A
V
A
G
R
I
ID
S
NS
R
L
VI
TS
--
-
-
-
-
---
-
--
--------
D
E
GVR
AG
R
S
I
P
L
KKN
VD
D
AL
KN
P
N
VT
SV
E
HVVV
LK
R
TGGKIDWQEGRDLWWHDLV
E
Q
A
SD
Q
HQ
A
EEM
N
A
E
D
P
L
F
IL
Y
TSG
S
TG
K
PKGVL
H
T
T
G
G
Y
L
----V
Y
A
A
-
L
TFK
YV
FDYHPG
D
I
Y
WCT
A
D
V
G
W
V
TG
HSYLLY
G
P
L
AC
GAT
T
LM
F
E
GV
PNWP
TP
A
R
MAQV
VDK
H
Q
V
N
----
I
L
YTA
P
TA
IR
A
LM
A
EG
DK
A
IEGTD
R
-
S
S
LR
I
L
G
----
SVGEP
IN
P
E
AWEWY
W
KK
I
G
N
E
KCPVV
DT
WW
Q
TET
GGFM
I
T
P
L
--
-
-
PG
AT
E
LKA
G
S
A
T
R
P
F
FGV
Q
PA
LVD
N
EGN
PL
E
G
A
T
EG
S
LV
I
TD
S
WPG
Q
A
R
TLF
GDHERFE
QT
YF
--
-
-S
T
F
K
N
M
---
--
YFSGD
GA
RRDE
D
GY
YW
ITGR
VD
DV
L
N
VS
G
HR
L
G
TA
EIES
A
L
VA
HPKI
A
E
A
A
VVGIP
H
N
I
K
G
Q
AI
Y
AYV
T
LN
H
-
GE
E
P
S
P
E
L
Y
AE
VR
N
W
V
RK
E
I
GP
L
A
T
P
DV
L
HWT
D
S
LP
K
T
R
SGKI
MRRI
LR
fig|585055.6.peg.4589
Escherichia coli 55989 (90-616/652)
GD
R
TAII
W
E
G
DD
AS
QSKH
I
SY
K
ELH
RDVC
R
F
AN
TL
L
E
LGIKKGD
V
VA
IY
M
P
MV
PE
A
A
V
AM
LACA
R
IGAV
H
SV
I
FGGFSP
E
A
V
A
G
R
I
ID
S
NS
R
L
VI
TS
--
-
-
-
-
---
-
--
--------
D
E
GVR
AG
R
S
I
P
L
KKN
VD
D
AL
KN
P
N
VT
SV
E
HVVV
LK
R
TGGKIDWQEGRDLWWHDLV
E
Q
A
SD
Q
HQ
A
EEM
N
A
E
D
P
L
F
IL
Y
TSG
S
TG
K
PKGVL
H
T
T
G
G
Y
L
----V
Y
A
A
-
L
TFK
YV
FDYHPG
D
I
Y
WCT
A
D
V
G
W
V
TG
HSYLLY
G
P
L
AC
GAT
T
LM
F
E
GV
PNWP
TP
A
R
MAQV
VDK
H
Q
V
N
----
I
L
YTA
P
TA
IR
A
LM
A
EG
DK
A
IEGTD
R
-
S
S
LR
I
L
G
----
SVGEP
IN
P
E
AWEWY
W
KK
I
G
N
E
KCPVV
DT
WW
Q
TET
GGFM
I
T
P
L
--
-
-
PG
AT
E
LKA
G
S
A
T
R
P
F
FGV
Q
PA
LVD
N
EGN
PL
E
G
A
T
EG
S
LV
I
TD
S
WPG
Q
A
R
TLF
GDHERFE
QT
YF
--
-
-S
T
F
K
N
M
---
--
YFSGD
GA
RRDE
D
GY
YW
ITGR
VD
DV
L
N
VS
G
HR
L
G
TA
EIES
A
L
VA
HPKI
A
E
A
A
VVGIP
H
N
I
K
G
Q
AI
Y
AYV
T
LN
H
-
GE
E
P
S
P
E
L
Y
AE
VR
N
W
V
RK
E
I
GP
L
A
T
P
DV
L
HWT
D
S
LP
K
T
R
SGKI
MRRI
LR
fig|585055.8.peg.4594
Escherichia coli 55989 (90-616/652)
GD
R
TAII
W
E
G
DD
AS
QSKH
I
SY
K
ELH
RDVC
R
F
AN
TL
L
E
LGIKKGD
V
VA
IY
M
P
MV
PE
A
A
V
AM
LACA
R
IGAV
H
SV
I
FGGFSP
E
A
V
A
G
R
I
ID
S
NS
R
L
VI
TS
--
-
-
-
-
---
-
--
--------
D
E
GVR
AG
R
S
I
P
L
KKN
VD
D
AL
KN
P
N
VT
SV
E
HVVV
LK
R
TGGKIDWQEGRDLWWHDLV
E
Q
A
SD
Q
HQ
A
EEM
N
A
E
D
P
L
F
IL
Y
TSG
S
TG
K
PKGVL
H
T
T
G
G
Y
L
----V
Y
A
A
-
L
TFK
YV
FDYHPG
D
I
Y
WCT
A
D
V
G
W
V
TG
HSYLLY
G
P
L
AC
GAT
T
LM
F
E
GV
PNWP
TP
A
R
MAQV
VDK
H
Q
V
N
----
I
L
YTA
P
TA
IR
A
LM
A
EG
DK
A
IEGTD
R
-
S
S
LR
I
L
G
----
SVGEP
IN
P
E
AWEWY
W
KK
I
G
N
E
KCPVV
DT
WW
Q
TET
GGFM
I
T
P
L
--
-
-
PG
AT
E
LKA
G
S
A
T
R
P
F
FGV
Q
PA
LVD
N
EGN
PL
E
G
A
T
EG
S
LV
I
TD
S
WPG
Q
A
R
TLF
GDHERFE
QT
YF
--
-
-S
T
F
K
N
M
---
--
YFSGD
GA
RRDE
D
GY
YW
ITGR
VD
DV
L
N
VS
G
HR
L
G
TA
EIES
A
L
VA
HPKI
A
E
A
A
VVGIP
H
N
I
K
G
Q
AI
Y
AYV
T
LN
H
-
GE
E
P
S
P
E
L
Y
AE
VR
N
W
V
RK
E
I
GP
L
A
T
P
DV
L
HWT
D
S
LP
K
T
R
SGKI
MRRI
LR
fig|481805.3.peg.4254
Escherichia coli ATCC 8739 (90-616/652)
GD
R
TAII
W
E
G
DD
AS
QSKH
I
SY
K
ELH
RDVC
R
F
AN
TL
L
E
LGIKKGD
V
VA
IY
M
P
MV
PE
A
A
V
AM
LACA
R
IGAV
H
SV
I
FGGFSP
E
A
V
A
G
R
I
ID
S
NS
R
L
VI
TS
--
-
-
-
-
---
-
--
--------
D
E
GVR
AG
R
S
I
P
L
KKN
VD
D
AL
KN
P
N
VT
SV
E
HVVV
LK
R
TGGKIDWQEGRDLWWHDLV
E
Q
A
SD
Q
HQ
A
EEM
N
A
E
D
P
L
F
IL
Y
TSG
S
TG
K
PKGVL
H
T
T
G
G
Y
L
----V
Y
A
A
-
L
TFK
YV
FDYHPG
D
I
Y
WCT
A
D
V
G
W
V
TG
HSYLLY
G
P
L
AC
GAT
T
LM
F
E
GV
PNWP
TP
A
R
MAQV
VDK
H
Q
V
N
----
I
L
YTA
P
TA
IR
A
LM
A
EG
DK
A
IEGTD
R
-
S
S
LR
I
L
G
----
SVGEP
IN
P
E
AWEWY
W
KK
I
G
N
E
KCPVV
DT
WW
Q
TET
GGFM
I
T
P
L
--
-
-
PG
AT
E
LKA
G
S
A
T
R
P
F
FGV
Q
PA
LVD
N
EGN
PL
E
G
A
T
EG
S
LV
I
TD
S
WPG
Q
A
R
TLF
GDHERFE
QT
YF
--
-
-S
T
F
K
N
M
---
--
YFSGD
GA
RRDE
D
GY
YW
ITGR
VD
DV
L
N
VS
G
HR
L
G
TA
EIES
A
L
VA
HPKI
A
E
A
A
VVGIP
H
N
I
K
G
Q
AI
Y
AYV
T
LN
H
-
GE
E
P
S
P
E
L
Y
AE
VR
N
W
V
RK
E
I
GP
L
A
T
P
DV
L
HWT
D
S
LP
K
T
R
SGKI
MRRI
LR
fig|481805.6.peg.4239
Escherichia coli ATCC 8739 (90-616/652)
GD
R
TAII
W
E
G
DD
AS
QSKH
I
SY
K
ELH
RDVC
R
F
AN
TL
L
E
LGIKKGD
V
VA
IY
M
P
MV
PE
A
A
V
AM
LACA
R
IGAV
H
SV
I
FGGFSP
E
A
V
A
G
R
I
ID
S
NS
R
L
VI
TS
--
-
-
-
-
---
-
--
--------
D
E
GVR
AG
R
S
I
P
L
KKN
VD
D
AL
KN
P
N
VT
SV
E
HVVV
LK
R
TGGKIDWQEGRDLWWHDLV
E
Q
A
SD
Q
HQ
A
EEM
N
A
E
D
P
L
F
IL
Y
TSG
S
TG
K
PKGVL
H
T
T
G
G
Y
L
----V
Y
A
A
-
L
TFK
YV
FDYHPG
D
I
Y
WCT
A
D
V
G
W
V
TG
HSYLLY
G
P
L
AC
GAT
T
LM
F
E
GV
PNWP
TP
A
R
MAQV
VDK
H
Q
V
N
----
I
L
YTA
P
TA
IR
A
LM
A
EG
DK
A
IEGTD
R
-
S
S
LR
I
L
G
----
SVGEP
IN
P
E
AWEWY
W
KK
I
G
N
E
KCPVV
DT
WW
Q
TET
GGFM
I
T
P
L
--
-
-
PG
AT
E
LKA
G
S
A
T
R
P
F
FGV
Q
PA
LVD
N
EGN
PL
E
G
A
T
EG
S
LV
I
TD
S
WPG
Q
A
R
TLF
GDHERFE
QT
YF
--
-
-S
T
F
K
N
M
---
--
YFSGD
GA
RRDE
D
GY
YW
ITGR
VD
DV
L
N
VS
G
HR
L
G
TA
EIES
A
L
VA
HPKI
A
E
A
A
VVGIP
H
N
I
K
G
Q
AI
Y
AYV
T
LN
H
-
GE
E
P
S
P
E
L
Y
AE
VR
N
W
V
RK
E
I
GP
L
A
T
P
DV
L
HWT
D
S
LP
K
T
R
SGKI
MRRI
LR
fig|413997.3.peg.4155
Escherichia coli B str. REL606 (90-616/652)
GD
R
TAII
W
E
G
DD
AS
QSKH
I
SY
K
ELH
RDVC
R
F
AN
TL
L
E
LGIKKGD
V
VA
IY
M
P
MV
PE
A
A
V
AM
LACA
R
IGAV
H
SV
I
FGGFSP
E
A
V
A
G
R
I
ID
S
NS
R
L
VI
TS
--
-
-
-
-
---
-
--
--------
D
E
GVR
AG
R
S
I
P
L
KKN
VD
D
AL
KN
P
N
VT
SV
E
HVVV
LK
R
TGGKIDWQEGRDLWWHDLV
E
Q
A
SD
Q
HQ
A
EEM
N
A
E
D
P
L
F
IL
Y
TSG
S
TG
K
PKGVL
H
T
T
G
G
Y
L
----V
Y
A
A
-
L
TFK
YV
FDYHPG
D
I
Y
WCT
A
D
V
G
W
V
TG
HSYLLY
G
P
L
AC
GAT
T
LM
F
E
GV
PNWP
TP
A
R
MAQV
VDK
H
Q
V
N
----
I
L
YTA
P
TA
IR
A
LM
A
EG
DK
A
IEGTD
R
-
S
S
LR
I
L
G
----
SVGEP
IN
P
E
AWEWY
W
KK
I
G
N
E
KCPVV
DT
WW
Q
TET
GGFM
I
T
P
L
--
-
-
PG
AT
E
LKA
G
S
A
T
R
P
F
FGV
Q
PA
LVD
N
EGN
PL
E
G
A
T
EG
S
LV
I
TD
S
WPG
Q
A
R
TLF
GDHERFE
QT
YF
--
-
-S
T
F
K
N
M
---
--
YFSGD
GA
RRDE
D
GY
YW
ITGR
VD
DV
L
N
VS
G
HR
L
G
TA
EIES
A
L
VA
HPKI
A
E
A
A
VVGIP
H
N
I
K
G
Q
AI
Y
AYV
T
LN
H
-
GE
E
P
S
P
E
L
Y
AE
VR
N
W
V
RK
E
I
GP
L
A
T
P
DV
L
HWT
D
S
LP
K
T
R
SGKI
MRRI
LR
fig|550672.3.peg.4152
Escherichia coli B088 (90-616/652)
GD
R
TAII
W
E
G
DD
AS
QSKH
I
SY
K
ELH
RDVC
R
F
AN
TL
L
E
LGIKKGD
V
VA
IY
M
P
MV
PE
A
A
V
AM
LACA
R
IGAV
H
SV
I
FGGFSP
E
A
V
A
G
R
I
ID
S
NS
R
L
VI
TS
--
-
-
-
-
---
-
--
--------
D
E
GVR
AG
R
S
I
P
L
KKN
VD
D
AL
KN
P
N
VT
SV
E
HVVV
LK
R
TGGKIDWQEGRDLWWHDLV
E
Q
A
SD
Q
HQ
A
EEM
N
A
E
D
P
L
F
IL
Y
TSG
S
TG
K
PKGVL
H
T
T
G
G
Y
L
----V
Y
A
A
-
L
TFK
YV
FDYHPG
D
I
Y
WCT
A
D
V
G
W
V
TG
HSYLLY
G
P
L
AC
GAT
T
LM
F
E
GV
PNWP
TP
A
R
MAQV
VDK
H
Q
V
N
----
I
L
YTA
P
TA
IR
A
LM
A
EG
DK
A
IEGTD
R
-
S
S
LR
I
L
G
----
SVGEP
IN
P
E
AWEWY
W
KK
I
G
N
E
KCPVV
DT
WW
Q
TET
GGFM
I
T
P
L
--
-
-
PG
AT
E
LKA
G
S
A
T
R
P
F
FGV
Q
PA
LVD
N
EGN
PL
E
G
A
T
EG
S
LV
I
TD
S
WPG
Q
A
R
TLF
GDHERFE
QT
YF
--
-
-S
T
F
K
N
M
---
--
YFSGD
GA
RRDE
D
GY
YW
ITGR
VD
DV
L
N
VS
G
HR
L
G
TA
EIES
A
L
VA
HPKI
A
E
A
A
VVGIP
H
N
I
K
G
Q
AI
Y
AYV
T
LN
H
-
GE
E
P
S
P
E
L
Y
AE
VR
N
W
V
RK
E
I
GP
L
A
T
P
DV
L
HWT
D
S
LP
K
T
R
SGKI
MRRI
LR
fig|344601.3.peg.1094
Escherichia coli B171 (90-616/652)
GD
R
TAII
W
E
G
DD
AS
QSKH
I
SY
K
ELH
RDVC
R
F
AN
TL
L
E
LGIKKGD
V
VA
IY
M
P
MV
PE
A
A
V
AM
LACA
R
IGAV
H
SV
I
FGGFSP
E
A
V
A
G
R
I
ID
S
NS
R
L
VI
TS
--
-
-
-
-
---
-
--
--------
D
E
GVR
AG
R
S
I
P
L
KKN
VD
D
AL
KN
P
N
VT
SV
E
HVVV
LK
R
TGGKIDWQEGRDLWWHDLV
E
Q
A
SD
Q
HQ
A
EEM
N
A
E
D
P
L
F
IL
Y
TSG
S
TG
K
PKGVL
H
T
T
G
G
Y
L
----V
Y
A
A
-
L
TFK
YV
FDYHPG
D
I
Y
WCT
A
D
V
G
W
V
TG
HSYLLY
G
P
L
AC
GAT
T
LM
F
E
GV
PNWP
TP
A
R
MAQV
VDK
H
Q
V
N
----
I
L
YTA
P
TA
IR
A
LM
A
EG
DK
A
IEGTD
R
-
S
S
LR
I
L
G
----
SVGEP
IN
P
E
AWEWY
W
KK
I
G
N
E
KCPVV
DT
WW
Q
TET
GGFM
I
T
P
L
--
-
-
PG
AT
E
LKA
G
S
A
T
R
P
F
FGV
Q
PA
LVD
N
EGN
PL
E
G
A
T
EG
S
LV
I
TD
S
WPG
Q
A
R
TLF
GDHERFE
QT
YF
--
-
-S
T
F
K
N
M
---
--
YFSGD
GA
RRDE
D
GY
YW
ITGR
VD
DV
L
N
VS
G
HR
L
G
TA
EIES
A
L
VA
HPKI
A
E
A
A
VVGIP
H
N
I
K
G
Q
AI
Y
AYV
T
LN
H
-
GE
E
P
S
P
E
L
Y
AE
VR
N
W
V
RK
E
I
GP
L
A
T
P
DV
L
HWT
D
S
LP
K
T
R
SGKI
MRRI
LR
fig|344601.5.peg.1159
Escherichia coli B171 (90-616/652)
GD
R
TAII
W
E
G
DD
AS
QSKH
I
SY
K
ELH
RDVC
R
F
AN
TL
L
E
LGIKKGD
V
VA
IY
M
P
MV
PE
A
A
V
AM
LACA
R
IGAV
H
SV
I
FGGFSP
E
A
V
A
G
R
I
ID
S
NS
R
L
VI
TS
--
-
-
-
-
---
-
--
--------
D
E
GVR
AG
R
S
I
P
L
KKN
VD
D
AL
KN
P
N
VT
SV
E
HVVV
LK
R
TGGKIDWQEGRDLWWHDLV
E
Q
A
SD
Q
HQ
A
EEM
N
A
E
D
P
L
F
IL
Y
TSG
S
TG
K
PKGVL
H
T
T
G
G
Y
L
----V
Y
A
A
-
L
TFK
YV
FDYHPG
D
I
Y
WCT
A
D
V
G
W
V
TG
HSYLLY
G
P
L
AC
GAT
T
LM
F
E
GV
PNWP
TP
A
R
MAQV
VDK
H
Q
V
N
----
I
L
YTA
P
TA
IR
A
LM
A
EG
DK
A
IEGTD
R
-
S
S
LR
I
L
G
----
SVGEP
IN
P
E
AWEWY
W
KK
I
G
N
E
KCPVV
DT
WW
Q
TET
GGFM
I
T
P
L
--
-
-
PG
AT
E
LKA
G
S
A
T
R
P
F
FGV
Q
PA
LVD
N
EGN
PL
E
G
A
T
EG
S
LV
I
TD
S
WPG
Q
A
R
TLF
GDHERFE
QT
YF
--
-
-S
T
F
K
N
M
---
--
YFSGD
GA
RRDE
D
GY
YW
ITGR
VD
DV
L
N
VS
G
HR
L
G
TA
EIES
A
L
VA
HPKI
A
E
A
A
VVGIP
H
N
I
K
G
Q
AI
Y
AYV
T
LN
H
-
GE
E
P
S
P
E
L
Y
AE
VR
N
W
V
RK
E
I
GP
L
A
T
P
DV
L
HWT
D
S
LP
K
T
R
SGKI
MRRI
LR
fig|511693.5.peg.4176
Escherichia coli BL21 (90-616/652)
GD
R
TAII
W
E
G
DD
AS
QSKH
I
SY
K
ELH
RDVC
R
F
AN
TL
L
E
LGIKKGD
V
VA
IY
M
P
MV
PE
A
A
V
AM
LACA
R
IGAV
H
SV
I
FGGFSP
E
A
V
A
G
R
I
ID
S
NS
R
L
VI
TS
--
-
-
-
-
---
-
--
--------
D
E
GVR
AG
R
S
I
P
L
KKN
VD
D
AL
KN
P
N
VT
SV
E
HVVV
LK
R
TGGKIDWQEGRDLWWHDLV
E
Q
A
SD
Q
HQ
A
EEM
N
A
E
D
P
L
F
IL
Y
TSG
S
TG
K
PKGVL
H
T
T
G
G
Y
L
----V
Y
A
A
-
L
TFK
YV
FDYHPG
D
I
Y
WCT
A
D
V
G
W
V
TG
HSYLLY
G
P
L
AC
GAT
T
LM
F
E
GV
PNWP
TP
A
R
MAQV
VDK
H
Q
V
N
----
I
L
YTA
P
TA
IR
A
LM
A
EG
DK
A
IEGTD
R
-
S
S
LR
I
L
G
----
SVGEP
IN
P
E
AWEWY
W
KK
I
G
N
E
KCPVV
DT
WW
Q
TET
GGFM
I
T
P
L
--
-
-
PG
AT
E
LKA
G
S
A
T
R
P
F
FGV
Q
PA
LVD
N
EGN
PL
E
G
A
T
EG
S
LV
I
TD
S
WPG
Q
A
R
TLF
GDHERFE
QT
YF
--
-
-S
T
F
K
N
M
---
--
YFSGD
GA
RRDE
D
GY
YW
ITGR
VD
DV
L
N
VS
G
HR
L
G
TA
EIES
A
L
VA
HPKI
A
E
A
A
VVGIP
H
N
I
K
G
Q
AI
Y
AYV
T
LN
H
-
GE
E
P
S
P
E
L
Y
AE
VR
N
W
V
RK
E
I
GP
L
A
T
P
DV
L
HWT
D
S
LP
K
T
R
SGKI
MRRI
LR
fig|469008.4.peg.4114
Escherichia coli BL21(DE3) (90-616/652)
GD
R
TAII
W
E
G
DD
AS
QSKH
I
SY
K
ELH
RDVC
R
F
AN
TL
L
E
LGIKKGD
V
VA
IY
M
P
MV
PE
A
A
V
AM
LACA
R
IGAV
H
SV
I
FGGFSP
E
A
V
A
G
R
I
ID
S
NS
R
L
VI
TS
--
-
-
-
-
---
-
--
--------
D
E
GVR
AG
R
S
I
P
L
KKN
VD
D
AL
KN
P
N
VT
SV
E
HVVV
LK
R
TGGKIDWQEGRDLWWHDLV
E
Q
A
SD
Q
HQ
A
EEM
N
A
E
D
P
L
F
IL
Y
TSG
S
TG
K
PKGVL
H
T
T
G
G
Y
L
----V
Y
A
A
-
L
TFK
YV
FDYHPG
D
I
Y
WCT
A
D
V
G
W
V
TG
HSYLLY
G
P
L
AC
GAT
T
LM
F
E
GV
PNWP
TP
A
R
MAQV
VDK
H
Q
V
N
----
I
L
YTA
P
TA
IR
A
LM
A
EG
DK
A
IEGTD
R
-
S
S
LR
I
L
G
----
SVGEP
IN
P
E
AWEWY
W
KK
I
G
N
E
KCPVV
DT
WW
Q
TET
GGFM
I
T
P
L
--
-
-
PG
AT
E
LKA
G
S
A
T
R
P
F
FGV
Q
PA
LVD
N
EGN
PL
E
G
A
T
EG
S
LV
I
TD
S
WPG
Q
A
R
TLF
GDHERFE
QT
YF
--
-
-S
T
F
K
N
M
---
--
YFSGD
GA
RRDE
D
GY
YW
ITGR
VD
DV
L
N
VS
G
HR
L
G
TA
EIES
A
L
VA
HPKI
A
E
A
A
VVGIP
H
N
I
K
G
Q
AI
Y
AYV
T
LN
H
-
GE
E
P
S
P
E
L
Y
AE
VR
N
W
V
RK
E
I
GP
L
A
T
P
DV
L
HWT
D
S
LP
K
T
R
SGKI
MRRI
LR
fig|595496.3.peg.4139
Escherichia coli BW2952 (90-616/652)
GD
R
TAII
W
E
G
DD
AS
QSKH
I
SY
K
ELH
RDVC
R
F
AN
TL
L
E
LGIKKGD
V
VA
IY
M
P
MV
PE
A
A
V
AM
LACA
R
IGAV
H
SV
I
FGGFSP
E
A
V
A
G
R
I
ID
S
NS
R
L
VI
TS
--
-
-
-
-
---
-
--
--------
D
E
GVR
AG
R
S
I
P
L
KKN
VD
D
AL
KN
P
N
VT
SV
E
HVVV
LK
R
TGGKIDWQEGRDLWWHDLV
E
Q
A
SD
Q
HQ
A
EEM
N
A
E
D
P
L
F
IL
Y
TSG
S
TG
K
PKGVL
H
T
T
G
G
Y
L
----V
Y
A
A
-
L
TFK
YV
FDYHPG
D
I
Y
WCT
A
D
V
G
W
V
TG
HSYLLY
G
P
L
AC
GAT
T
LM
F
E
GV
PNWP
TP
A
R
MAQV
VDK
H
Q
V
N
----
I
L
YTA
P
TA
IR
A
LM
A
EG
DK
A
IEGTD
R
-
S
S
LR
I
L
G
----
SVGEP
IN
P
E
AWEWY
W
KK
I
G
N
E
KCPVV
DT
WW
Q
TET
GGFM
I
T
P
L
--
-
-
PG
AT
E
LKA
G
S
A
T
R
P
F
FGV
Q
PA
LVD
N
EGN
PL
E
G
A
T
EG
S
LV
I
TD
S
WPG
Q
A
R
TLF
GDHERFE
QT
YF
--
-
-S
T
F
K
N
M
---
--
YFSGD
GA
RRDE
D
GY
YW
ITGR
VD
DV
L
N
VS
G
HR
L
G
TA
EIES
A
L
VA
HPKI
A
E
A
A
VVGIP
H
N
I
K
G
Q
AI
Y
AYV
T
LN
H
-
GE
E
P
S
P
E
L
Y
AE
VR
N
W
V
RK
E
I
GP
L
A
T
P
DV
L
HWT
D
S
LP
K
T
R
SGKI
MRRI
LR
fig|536056.3.peg.4167
Escherichia coli DH1 (90-616/652)
GD
R
TAII
W
E
G
DD
AS
QSKH
I
SY
K
ELH
RDVC
R
F
AN
TL
L
E
LGIKKGD
V
VA
IY
M
P
MV
PE
A
A
V
AM
LACA
R
IGAV
H
SV
I
FGGFSP
E
A
V
A
G
R
I
ID
S
NS
R
L
VI
TS
--
-
-
-
-
---
-
--
--------
D
E
GVR
AG
R
S
I
P
L
KKN
VD
D
AL
KN
P
N
VT
SV
E
HVVV
LK
R
TGGKIDWQEGRDLWWHDLV
E
Q
A
SD
Q
HQ
A
EEM
N
A
E
D
P
L
F
IL
Y
TSG
S
TG
K
PKGVL
H
T
T
G
G
Y
L
----V
Y
A
A
-
L
TFK
YV
FDYHPG
D
I
Y
WCT
A
D
V
G
W
V
TG
HSYLLY
G
P
L
AC
GAT
T
LM
F
E
GV
PNWP
TP
A
R
MAQV
VDK
H
Q
V
N
----
I
L
YTA
P
TA
IR
A
LM
A
EG
DK
A
IEGTD
R
-
S
S
LR
I
L
G
----
SVGEP
IN
P
E
AWEWY
W
KK
I
G
N
E
KCPVV
DT
WW
Q
TET
GGFM
I
T
P
L
--
-
-
PG
AT
E
LKA
G
S
A
T
R
P
F
FGV
Q
PT
LVD
N
EGN
PL
E
G
A
T
EG
S
LV
I
TD
S
WPG
Q
A
R
TLF
GDHERFE
QT
YF
--
-
-S
T
F
K
N
M
---
--
YFSGD
GA
RRDE
D
GY
YW
ITGR
VD
DV
L
N
VS
G
HR
L
G
TA
EIES
A
L
VA
HPKI
A
E
A
A
VVGIP
H
N
I
K
G
Q
AI
Y
AYV
T
LN
H
-
GE
E
P
S
P
E
L
Y
AE
VR
N
W
V
RK
E
I
GP
L
A
T
P
DV
L
HWT
D
S
LP
K
T
R
SGKI
MRRI
LR
fig|340186.3.peg.998
Escherichia coli E110019 (90-616/652)
GD
R
TAII
W
E
G
DD
AS
QSKH
I
SY
K
ELH
RDVC
R
F
AN
TL
L
E
LGIKKGD
V
VA
IY
M
P
MV
PE
A
A
V
AM
LACA
R
IGAV
H
SV
I
FGGFSP
E
A
V
A
G
R
I
ID
S
NS
R
L
VI
TS
--
-
-
-
-
---
-
--
--------
D
E
GVR
AG
R
S
I
P
L
KKN
VD
D
AL
KN
P
N
VT
SV
E
HVVV
LK
R
TGGKIDWQEGRDLWWHDLV
E
Q
A
SD
Q
HQ
A
EEM
N
A
E
D
P
L
F
IL
Y
TSG
S
TG
K
PKGVL
H
T
T
G
G
Y
L
----V
Y
A
A
-
L
TFK
YV
FDYHPG
D
I
Y
WCT
A
D
V
G
W
V
TG
HSYLLY
G
P
L
AC
GAT
T
LM
F
E
GV
PNWP
TP
A
R
MAQV
VDK
H
Q
V
N
----
I
L
YTA
P
TA
IR
A
LM
A
EG
DK
A
IEGTD
R
-
S
S
LR
I
L
G
----
SVGEP
IN
P
E
AWEWY
W
KK
I
G
N
E
KCPVV
DT
WW
Q
TET
GGFM
I
T
P
L
--
-
-
PG
AT
E
LKA
G
S
A
T
R
P
F
FGV
Q
PA
LVD
N
EGN
PL
E
G
A
T
EG
S
LV
I
TD
S
WPG
Q
A
R
TLF
GDHERFE
QT
YF
--
-
-S
T
F
K
N
M
---
--
YFSGD
GA
RRDE
D
GY
YW
ITGR
VD
DV
L
N
VS
G
HR
L
G
TA
EIES
A
L
VA
HPKI
A
E
A
A
VVGIP
H
N
I
K
G
Q
AI
Y
AYV
T
LN
H
-
GE
E
P
S
P
E
L
Y
AE
VR
N
W
V
RK
E
I
GP
L
A
T
P
DV
L
HWT
D
S
LP
K
T
R
SGKI
MRRI
LR
fig|340186.5.peg.1040
Escherichia coli E110019 (90-616/652)
GD
R
TAII
W
E
G
DD
AS
QSKH
I
SY
K
ELH
RDVC
R
F
AN
TL
L
E
LGIKKGD
V
VA
IY
M
P
MV
PE
A
A
V
AM
LACA
R
IGAV
H
SV
I
FGGFSP
E
A
V
A
G
R
I
ID
S
NS
R
L
VI
TS
--
-
-
-
-
---
-
--
--------
D
E
GVR
AG
R
S
I
P
L
KKN
VD
D
AL
KN
P
N
VT
SV
E
HVVV
LK
R
TGGKIDWQEGRDLWWHDLV
E
Q
A
SD
Q
HQ
A
EEM
N
A
E
D
P
L
F
IL
Y
TSG
S
TG
K
PKGVL
H
T
T
G
G
Y
L
----V
Y
A
A
-
L
TFK
YV
FDYHPG
D
I
Y
WCT
A
D
V
G
W
V
TG
HSYLLY
G
P
L
AC
GAT
T
LM
F
E
GV
PNWP
TP
A
R
MAQV
VDK
H
Q
V
N
----
I
L
YTA
P
TA
IR
A
LM
A
EG
DK
A
IEGTD
R
-
S
S
LR
I
L
G
----
SVGEP
IN
P
E
AWEWY
W
KK
I
G
N
E
KCPVV
DT
WW
Q
TET
GGFM
I
T
P
L
--
-
-
PG
AT
E
LKA
G
S
A
T
R
P
F
FGV
Q
PA
LVD
N
EGN
PL
E
G
A
T
EG
S
LV
I
TD
S
WPG
Q
A
R
TLF
GDHERFE
QT
YF
--
-
-S
T
F
K
N
M
---
--
YFSGD
GA
RRDE
D
GY
YW
ITGR
VD
DV
L
N
VS
G
HR
L
G
TA
EIES
A
L
VA
HPKI
A
E
A
A
VVGIP
H
N
I
K
G
Q
AI
Y
AYV
T
LN
H
-
GE
E
P
S
P
E
L
Y
AE
VR
N
W
V
RK
E
I
GP
L
A
T
P
DV
L
HWT
D
S
LP
K
T
R
SGKI
MRRI
LR
fig|340185.3.peg.1356
Escherichia coli E22 (90-616/652)
GD
R
TAII
W
E
G
DD
AS
QSKH
I
SY
K
ELH
RDVC
R
F
AN
TL
L
E
LGIKKGD
V
VA
IY
M
P
MV
PE
A
A
V
AM
LACA
R
IGAV
H
SV
I
FGGFSP
E
A
V
A
G
R
I
ID
S
NS
R
L
VI
TS
--
-
-
-
-
---
-
--
--------
D
E
GVR
AG
R
S
I
P
L
KKN
VD
D
AL
KN
P
N
VT
SV
E
HVVV
LK
R
TGGKIDWQEGRDLWWHDLV
E
Q
A
SD
Q
HQ
A
EEM
N
A
E
D
P
L
F
IL
Y
TSG
S
TG
K
PKGVL
H
T
T
G
G
Y
L
----V
Y
A
A
-
L
TFK
YV
FDYHPG
D
I
Y
WCT
A
D
V
G
W
V
TG
HSYLLY
G
P
L
AC
GAT
T
LM
F
E
GV
PNWP
TP
A
R
MAQV
VDK
H
Q
V
N
----
I
L
YTA
P
TA
IR
A
LM
A
EG
DK
A
IEGTD
R
-
S
S
LR
I
L
G
----
SVGEP
IN
P
E
AWEWY
W
KK
I
G
N
E
KCPVV
DT
WW
Q
TET
GGFM
I
T
P
L
--
-
-
PG
AT
E
LKA
G
S
A
T
R
P
F
FGV
Q
PA
LVD
N
EGN
PL
E
G
A
T
EG
S
LV
I
TD
S
WPG
Q
A
R
TLF
GDHERFE
QT
YF
--
-
-S
T
F
K
N
M
---
--
YFSGD
GA
RRDE
D
GY
YW
ITGR
VD
DV
L
N
VS
G
HR
L
G
TA
EIES
A
L
VA
HPKI
A
E
A
A
VVGIP
H
N
I
K
G
Q
AI
Y
AYV
T
LN
H
-
GE
E
P
S
P
E
L
Y
AE
VR
N
W
V
RK
E
I
GP
L
A
T
P
DV
L
HWT
D
S
LP
K
T
R
SGKI
MRRI
LR
fig|340185.4.peg.1439
Escherichia coli E22 (90-616/652)
GD
R
TAII
W
E
G
DD
AS
QSKH
I
SY
K
ELH
RDVC
R
F
AN
TL
L
E
LGIKKGD
V
VA
IY
M
P
MV
PE
A
A
V
AM
LACA
R
IGAV
H
SV
I
FGGFSP
E
A
V
A
G
R
I
ID
S
NS
R
L
VI
TS
--
-
-
-
-
---
-
--
--------
D
E
GVR
AG
R
S
I
P
L
KKN
VD
D
AL
KN
P
N
VT
SV
E
HVVV
LK
R
TGGKIDWQEGRDLWWHDLV
E
Q
A
SD
Q
HQ
A
EEM
N
A
E
D
P
L
F
IL
Y
TSG
S
TG
K
PKGVL
H
T
T
G
G
Y
L
----V
Y
A
A
-
L
TFK
YV
FDYHPG
D
I
Y
WCT
A
D
V
G
W
V
TG
HSYLLY
G
P
L
AC
GAT
T
LM
F
E
GV
PNWP
TP
A
R
MAQV
VDK
H
Q
V
N
----
I
L
YTA
P
TA
IR
A
LM
A
EG
DK
A
IEGTD
R
-
S
S
LR
I
L
G
----
SVGEP
IN
P
E
AWEWY
W
KK
I
G
N
E
KCPVV
DT
WW
Q
TET
GGFM
I
T
P
L
--
-
-
PG
AT
E
LKA
G
S
A
T
R
P
F
FGV
Q
PA
LVD
N
EGN
PL
E
G
A
T
EG
S
LV
I
TD
S
WPG
Q
A
R
TLF
GDHERFE
QT
YF
--
-
-S
T
F
K
N
M
---
--
YFSGD
GA
RRDE
D
GY
YW
ITGR
VD
DV
L
N
VS
G
HR
L
G
TA
EIES
A
L
VA
HPKI
A
E
A
A
VVGIP
H
N
I
K
G
Q
AI
Y
AYV
T
LN
H
-
GE
E
P
S
P
E
L
Y
AE
VR
N
W
V
RK
E
I
GP
L
A
T
P
DV
L
HWT
D
S
LP
K
T
R
SGKI
MRRI
LR
fig|216593.1.peg.3946
Escherichia coli E2348/69 (90-616/652)
GD
R
TAII
W
E
G
DD
AS
QSKH
I
SY
K
ELH
RDVC
R
F
AN
TL
L
E
LGIKKGD
V
VA
IY
M
P
MV
PE
A
A
V
AM
LACA
R
IGAV
H
SV
I
FGGFSP
E
A
V
A
G
R
I
ID
S
NS
R
L
VI
TS
--
-
-
-
-
---
-
--
--------
D
E
GVR
AG
R
S
I
P
L
KKN
VD
D
AL
KN
P
N
VT
SV
E
HVVV
LK
R
TGGKIDWQEGRDLWWHDLV
E
Q
A
SD
Q
HQ
A
EEM
N
A
E
D
P
L
F
IL
Y
TSG
S
TG
K
PKGVL
H
T
T
G
G
Y
L
----V
Y
A
A
-
L
TFK
YV
FDYHPG
D
I
Y
WCT
A
D
V
G
W
V
TG
HSYLLY
G
P
L
AC
GAT
T
LM
F
E
GV
PNWP
TP
A
R
MAQV
VDK
H
Q
V
N
----
I
L
YTA
P
TA
IR
A
LM
A
EG
DK
A
IEGTD
R
-
S
S
LR
I
L
G
----
SVGEP
IN
P
E
AWEWY
W
KK
I
G
N
E
KCPVV
DT
WW
Q
TET
GGFM
I
T
P
L
--
-
-
PG
AT
E
LKA
G
S
A
T
R
P
F
FGV
Q
PA
LVD
N
EGN
PL
E
G
A
T
EG
S
LV
I
TD
S
WPG
Q
A
R
TLF
GDHERFE
QT
YF
--
-
-S
T
F
K
N
M
---
--
YFSGD
GA
RRDE
D
GY
YW
ITGR
VD
DV
L
N
VS
G
HR
L
G
TA
EIES
A
L
VA
HPKI
A
E
A
A
VVGIP
H
N
I
K
G
Q
AI
Y
AYV
T
LN
H
-
GE
E
P
S
P
E
L
Y
AE
VR
N
W
V
RK
E
I
GP
L
A
T
P
DV
L
HWT
D
S
LP
K
T
R
SGKI
MRRI
LR
fig|331111.12.peg.4834
Escherichia coli E24377A (90-616/652)
GD
R
TAII
W
E
G
DD
AS
QSKH
I
SY
K
ELH
RDVC
R
F
AN
TL
L
E
LGIKKGD
V
VA
IY
M
P
MV
PE
A
A
V
AM
LACA
R
IGAV
H
SV
I
FGGFSP
E
A
V
A
G
R
I
ID
S
NS
R
L
VI
TS
--
-
-
-
-
---
-
--
--------
D
E
GVR
AG
R
S
I
P
L
KKN
VD
D
AL
KN
P
N
VT
SV
E
HVVV
LK
R
TGGKIDWQEGRDLWWHDLV
E
Q
A
SD
Q
HQ
A
EEM
N
A
E
D
P
L
F
IL
Y
TSG
S
TG
K
PKGVL
H
T
T
G
G
Y
L
----V
Y
A
A
-
L
TFK
YV
FDYHPG
D
I
Y
WCT
A
D
V
G
W
V
TG
HSYLLY
G
P
L
AC
GAT
T
LM
F
E
GV
PNWP
TP
A
R
MAQV
VDK
H
Q
V
N
----
I
L
YTA
P
TA
IR
A
LM
A
EG
DK
A
IEGTD
R
-
S
S
LR
I
L
G
----
SVGEP
IN
P
E
AWEWY
W
KK
I
G
N
E
KCPVV
DT
WW
Q
TET
GGFM
I
T
P
L
--
-
-
PG
AT
E
LKA
G
S
A
T
R
P
F
FGV
Q
PA
LVD
N
EGN
PL
E
G
A
T
EG
S
LV
I
TD
S
WPG
Q
A
R
TLF
GDHERFE
QT
YF
--
-
-S
T
F
K
N
M
---
--
YFSGD
GA
RRDE
D
GY
YW
ITGR
VD
DV
L
N
VS
G
HR
L
G
TA
EIES
A
L
VA
HPKI
A
E
A
A
VVGIP
H
N
I
K
G
Q
AI
Y
AYV
T
LN
H
-
GE
E
P
S
P
E
L
Y
AE
VR
N
W
V
RK
E
I
GP
L
A
T
P
DV
L
HWT
D
S
LP
K
T
R
SGKI
MRRI
LR
fig|331111.3.peg.2223
Escherichia coli E24377A (90-616/652)
GD
R
TAII
W
E
G
DD
AS
QSKH
I
SY
K
ELH
RDVC
R
F
AN
TL
L
E
LGIKKGD
V
VA
IY
M
P
MV
PE
A
A
V
AM
LACA
R
IGAV
H
SV
I
FGGFSP
E
A
V
A
G
R
I
ID
S
NS
R
L
VI
TS
--
-
-
-
-
---
-
--
--------
D
E
GVR
AG
R
S
I
P
L
KKN
VD
D
AL
KN
P
N
VT
SV
E
HVVV
LK
R
TGGKIDWQEGRDLWWHDLV
E
Q
A
SD
Q
HQ
A
EEM
N
A
E
D
P
L
F
IL
Y
TSG
S
TG
K
PKGVL
H
T
T
G
G
Y
L
----V
Y
A
A
-
L
TFK
YV
FDYHPG
D
I
Y
WCT
A
D
V
G
W
V
TG
HSYLLY
G
P
L
AC
GAT
T
LM
F
E
GV
PNWP
TP
A
R
MAQV
VDK
H
Q
V
N
----
I
L
YTA
P
TA
IR
A
LM
A
EG
DK
A
IEGTD
R
-
S
S
LR
I
L
G
----
SVGEP
IN
P
E
AWEWY
W
KK
I
G
N
E
KCPVV
DT
WW
Q
TET
GGFM
I
T
P
L
--
-
-
PG
AT
E
LKA
G
S
A
T
R
P
F
FGV
Q
PA
LVD
N
EGN
PL
E
G
A
T
EG
S
LV
I
TD
S
WPG
Q
A
R
TLF
GDHERFE
QT
YF
--
-
-S
T
F
K
N
M
---
--
YFSGD
GA
RRDE
D
GY
YW
ITGR
VD
DV
L
N
VS
G
HR
L
G
TA
EIES
A
L
VA
HPKI
A
E
A
A
VVGIP
H
N
I
K
G
Q
AI
Y
AYV
T
LN
H
-
GE
E
P
S
P
E
L
Y
AE
VR
N
W
V
RK
E
I
GP
L
A
T
P
DV
L
HWT
D
S
LP
K
T
R
SGKI
MRRI
LR
fig|562.375.peg.3011
Escherichia coli EC4100B (90-616/652)
GD
R
TAII
W
E
G
DD
AS
QSKH
I
SY
K
ELH
RDVC
R
F
AN
TL
L
E
LGIKKGD
V
VA
IY
M
P
MV
PE
A
A
V
AM
LACA
R
IGAV
H
SV
I
FGGFSP
E
A
V
A
G
R
I
ID
S
NS
R
L
VI
TS
--
-
-
-
-
---
-
--
--------
D
E
GVR
AG
R
S
I
P
L
KKN
VD
D
AL
KN
P
N
VT
SV
E
HVVV
LK
R
TGGKIDWQEGRDLWWHDLV
E
Q
A
SD
Q
HQ
A
EEM
N
A
E
D
P
L
F
IL
Y
TSG
S
TG
K
PKGVL
H
T
T
G
G
Y
L
----V
Y
A
A
-
L
TFK
YV
FDYHPG
D
I
Y
WCT
A
D
V
G
W
V
TG
HSYLLY
G
P
L
AC
GAT
T
LM
F
E
GV
PNWP
TP
A
R
MAQV
VDK
H
Q
V
N
----
I
L
YTA
P
TA
IR
A
LM
A
EG
DK
A
IEGTD
R
-
S
S
LR
I
L
G
----
SVGEP
IN
P
E
AWEWY
W
KK
I
G
N
E
KCPVV
DT
WW
Q
TET
GGFM
I
T
P
L
--
-
-
PG
AT
E
LKA
G
S
A
T
R
P
F
FGV
Q
PA
LVD
N
EGN
PL
E
G
A
T
EG
S
LV
I
TD
S
WPG
Q
A
R
TLF
GDHERFE
QT
YF
--
-
-S
T
F
K
N
M
---
--
YFSGD
GA
RRDE
D
GY
YW
ITGR
VD
DV
L
N
VS
G
HR
L
G
TA
EIES
A
L
VA
HPKI
A
E
A
A
VVGIP
H
N
I
K
G
Q
AI
Y
AYV
T
LN
H
-
GE
E
P
S
P
E
L
Y
AE
VR
N
W
V
RK
E
I
GP
L
A
T
P
DV
L
HWT
D
S
LP
K
T
R
SGKI
MRRI
LR
fig|316401.4.peg.4972
Escherichia coli ETEC H10407 (90-616/652)
GD
R
TAII
W
E
G
DD
AS
QSKH
I
SY
K
ELH
RDVC
R
F
AN
TL
L
E
LGIKKGD
V
VA
IY
M
P
MV
PE
A
A
V
AM
LACA
R
IGAV
H
SV
I
FGGFSP
E
A
V
A
G
R
I
ID
S
NS
R
L
VI
TS
--
-
-
-
-
---
-
--
--------
D
E
GVR
AG
R
S
I
P
L
KKN
VD
D
AL
KN
P
N
VT
SV
E
HVVV
LK
R
TGGKIDWQEGRDLWWHDLV
E
Q
A
SD
Q
HQ
A
EEM
N
A
E
D
P
L
F
IL
Y
TSG
S
TG
K
PKGVL
H
T
T
G
G
Y
L
----V
Y
A
A
-
L
TFK
YV
FDYHPG
D
I
Y
WCT
A
D
V
G
W
V
TG
HSYLLY
G
P
L
AC
GAT
T
LM
F
E
GV
PNWP
TP
A
R
MAQV
VDK
H
Q
V
N
----
I
L
YTA
P
TA
IR
A
LM
A
EG
DK
A
IEGTD
R
-
S
S
LR
I
L
G
----
SVGEP
IN
P
E
AWEWY
W
KK
I
G
N
E
KCPVV
DT
WW
Q
TET
GGFM
I
T
P
L
--
-
-
PG
AT
E
LKA
G
S
A
T
R
P
F
FGV
Q
PA
LVD
N
EGN
PL
E
G
A
T
EG
S
LV
I
TD
S
WPG
Q
A
R
TLF
GDHERFE
QT
YF
--
-
-S
T
F
K
N
M
---
--
YFSGD
GA
RRDE
D
GY
YW
ITGR
VD
DV
L
N
VS
G
HR
L
G
TA
EIES
A
L
VA
HPKI
A
E
A
A
VVGIP
H
N
I
K
G
Q
AI
Y
AYV
T
LN
H
-
GE
E
P
S
P
E
L
Y
AE
VR
N
W
V
RK
E
I
GP
L
A
T
P
DV
L
HWT
D
S
LP
K
T
R
SGKI
MRRI
LR
fig|656408.3.peg.4568
Escherichia coli H591 (90-616/652)
GD
R
TAII
W
E
G
DD
AS
QSKH
I
SY
K
ELH
RDVC
R
F
AN
TL
L
E
LGIKKGD
V
VA
IY
M
P
MV
PE
A
A
V
AM
LACA
R
IGAV
H
SV
I
FGGFSP
E
A
V
A
G
R
I
ID
S
NS
R
L
VI
TS
--
-
-
-
-
---
-
--
--------
D
E
GVR
AG
R
S
I
P
L
KKN
VD
D
AL
KN
P
N
VT
SV
E
HVVV
LK
R
TGGKIDWQEGRDLWWHDLV
E
Q
A
SD
Q
HQ
A
EEM
N
A
E
D
P
L
F
IL
Y
TSG
S
TG
K
PKGVL
H
T
T
G
G
Y
L
----V
Y
A
A
-
L
TFK
YV
FDYHPG
D
I
Y
WCT
A
D
V
G
W
V
TG
HSYLLY
G
P
L
AC
GAT
T
LM
F
E
GV
PNWP
TP
A
R
MAQV
VDK
H
Q
V
N
----
I
L
YTA
P
TA
IR
A
LM
A
EG
DK
A
IEGTD
R
-
S
S
LR
I
L
G
----
SVGEP
IN
P
E
AWEWY
W
KK
I
G
N
E
KCPVV
DT
WW
Q
TET
GGFM
I
T
P
L
--
-
-
PG
AT
E
LKA
G
S
A
T
R
P
F
FGV
Q
PA
LVD
N
EGN
PL
E
G
A
T
EG
S
LV
I
TD
S
WPG
Q
A
R
TLF
GDHERFE
QT
YF
--
-
-S
T
F
K
N
M
---
--
YFSGD
GA
RRDE
D
GY
YW
ITGR
VD
DV
L
N
VS
G
HR
L
G
TA
EIES
A
L
VA
HPKI
A
E
A
A
VVGIP
H
N
I
K
G
Q
AI
Y
AYV
T
LN
H
-
GE
E
P
S
P
E
L
Y
AE
VR
N
W
V
RK
E
I
GP
L
A
T
P
DV
L
HWT
D
S
LP
K
T
R
SGKI
MRRI
LR
fig|656414.3.peg.4621
Escherichia coli H736 (90-616/652)
GD
R
TAII
W
E
G
DD
AS
QSKH
I
SY
K
ELH
RDVC
R
F
AN
TL
L
E
LGIKKGD
V
VA
IY
M
P
MV
PE
A
A
V
AM
LACA
R
IGAV
H
SV
I
FGGFSP
E
A
V
A
G
R
I
ID
S
NS
R
L
VI
TS
--
-
-
-
-
---
-
--
--------
D
E
GVR
AG
R
S
I
P
L
KKN
VD
D
AL
KN
P
N
VT
SV
E
HVVV
LK
R
TGGKIDWQEGRDLWWHDLV
E
Q
A
SD
Q
HQ
A
EEM
N
A
E
D
P
L
F
IL
Y
TSG
S
TG
K
PKGVL
H
T
T
G
G
Y
L
----V
Y
A
A
-
L
TFK
YV
FDYHPG
D
I
Y
WCT
A
D
V
G
W
V
TG
HSYLLY
G
P
L
AC
GAT
T
LM
F
E
GV
PNWP
TP
A
R
MAQV
VDK
H
Q
V
N
----
I
L
YTA
P
TA
IR
A
LM
A
EG
DK
A
IEGTD
R
-
S
S
LR
I
L
G
----
SVGEP
IN
P
E
AWEWY
W
KK
I
G
N
E
KCPVV
DT
WW
Q
TET
GGFM
I
T
P
L
--
-
-
PG
AT
E
LKA
G
S
A
T
R
P
F
FGV
Q
PA
LVD
N
EGN
PL
E
G
A
T
EG
S
LV
I
TD
S
WPG
Q
A
R
TLF
GDHERFE
QT
YF
--
-
-S
T
F
K
N
M
---
--
YFSGD
GA
RRDE
D
GY
YW
ITGR
VD
DV
L
N
VS
G
HR
L
G
TA
EIES
A
L
VA
HPKI
A
E
A
A
VVGIP
H
N
I
K
G
Q
AI
Y
AYV
T
LN
H
-
GE
E
P
S
P
E
L
Y
AE
VR
N
W
V
RK
E
I
GP
L
A
T
P
DV
L
HWT
D
S
LP
K
T
R
SGKI
MRRI
LR
fig|331112.3.peg.4025
Escherichia coli HS (90-616/652)
GD
R
TAII
W
E
G
DD
AS
QSKH
I
SY
K
ELH
RDVC
R
F
AN
TL
L
E
LGIKKGD
V
VA
IY
M
P
MV
PE
A
A
V
AM
LACA
R
IGAV
H
SV
I
FGGFSP
E
A
V
A
G
R
I
ID
S
NS
R
L
VI
TS
--
-
-
-
-
---
-
--
--------
D
E
GVR
AG
R
S
I
P
L
KKN
VD
D
AL
KN
P
N
VT
SV
E
HVVV
LK
R
TGGKIDWQEGRDLWWHDLV
E
Q
A
SD
Q
HQ
A
EEM
N
A
E
D
P
L
F
IL
Y
TSG
S
TG
K
PKGVL
H
T
T
G
G
Y
L
----V
Y
A
A
-
L
TFK
YV
FDYHPG
D
I
Y
WCT
A
D
V
G
W
V
TG
HSYLLY
G
P
L
AC
GAT
T
LM
F
E
GV
PNWP
TP
A
R
MAQV
VDK
H
Q
V
N
----
I
L
YTA
P
TA
IR
A
LM
A
EG
DK
A
IEGTD
R
-
S
S
LR
I
L
G
----
SVGEP
IN
P
E
AWEWY
W
KK
I
G
N
E
KCPVV
DT
WW
Q
TET
GGFM
I
T
P
L
--
-
-
PG
AT
E
LKA
G
S
A
T
R
P
F
FGV
Q
PA
LVD
N
EGN
PL
E
G
A
T
EG
S
LV
I
TD
S
WPG
Q
A
R
TLF
GDHERFE
QT
YF
--
-
-S
T
F
K
N
M
---
--
YFSGD
GA
RRDE
D
GY
YW
ITGR
VD
DV
L
N
VS
G
HR
L
G
TA
EIES
A
L
VA
HPKI
A
E
A
A
VVGIP
H
N
I
K
G
Q
AI
Y
AYV
T
LN
H
-
GE
E
P
S
P
E
L
Y
AE
VR
N
W
V
RK
E
I
GP
L
A
T
P
DV
L
HWT
D
S
LP
K
T
R
SGKI
MRRI
LR
fig|331112.6.peg.4202
Escherichia coli HS (90-616/652)
GD
R
TAII
W
E
G
DD
AS
QSKH
I
SY
K
ELH
RDVC
R
F
AN
TL
L
E
LGIKKGD
V
VA
IY
M
P
MV
PE
A
A
V
AM
LACA
R
IGAV
H
SV
I
FGGFSP
E
A
V
A
G
R
I
ID
S
NS
R
L
VI
TS
--
-
-
-
-
---
-
--
--------
D
E
GVR
AG
R
S
I
P
L
KKN
VD
D
AL
KN
P
N
VT
SV
E
HVVV
LK
R
TGGKIDWQEGRDLWWHDLV
E
Q
A
SD
Q
HQ
A
EEM
N
A
E
D
P
L
F
IL
Y
TSG
S
TG
K
PKGVL
H
T
T
G
G
Y
L
----V
Y
A
A
-
L
TFK
YV
FDYHPG
D
I
Y
WCT
A
D
V
G
W
V
TG
HSYLLY
G
P
L
AC
GAT
T
LM
F
E
GV
PNWP
TP
A
R
MAQV
VDK
H
Q
V
N
----
I
L
YTA
P
TA
IR
A
LM
A
EG
DK
A
IEGTD
R
-
S
S
LR
I
L
G
----
SVGEP
IN
P
E
AWEWY
W
KK
I
G
N
E
KCPVV
DT
WW
Q
TET
GGFM
I
T
P
L
--
-
-
PG
AT
E
LKA
G
S
A
T
R
P
F
FGV
Q
PA
LVD
N
EGN
PL
E
G
A
T
EG
S
LV
I
TD
S
WPG
Q
A
R
TLF
GDHERFE
QT
YF
--
-
-S
T
F
K
N
M
---
--
YFSGD
GA
RRDE
D
GY
YW
ITGR
VD
DV
L
N
VS
G
HR
L
G
TA
EIES
A
L
VA
HPKI
A
E
A
A
VVGIP
H
N
I
K
G
Q
AI
Y
AYV
T
LN
H
-
GE
E
P
S
P
E
L
Y
AE
VR
N
W
V
RK
E
I
GP
L
A
T
P
DV
L
HWT
D
S
LP
K
T
R
SGKI
MRRI
LR
fig|585034.4.peg.4181
Escherichia coli IAI1 (90-616/652)
GD
R
TAII
W
E
G
DD
AS
QSKH
I
SY
K
ELH
RDVC
R
F
AN
TL
L
E
LGIKKGD
V
VA
IY
M
P
MV
PE
A
A
V
AM
LACA
R
IGAV
H
SV
I
FGGFSP
E
A
V
A
G
R
I
ID
S
NS
R
L
VI
TS
--
-
-
-
-
---
-
--
--------
D
E
GVR
AG
R
S
I
P
L
KKN
VD
D
AL
KN
P
N
VT
SV
E
HVVV
LK
R
TGGKIDWQEGRDLWWHDLV
E
Q
A
SD
Q
HQ
A
EEM
N
A
E
D
P
L
F
IL
Y
TSG
S
TG
K
PKGVL
H
T
T
G
G
Y
L
----V
Y
A
A
-
L
TFK
YV
FDYHPG
D
I
Y
WCT
A
D
V
G
W
V
TG
HSYLLY
G
P
L
AC
GAT
T
LM
F
E
GV
PNWP
TP
A
R
MAQV
VDK
H
Q
V
N
----
I
L
YTA
P
TA
IR
A
LM
A
EG
DK
A
IEGTD
R
-
S
S
LR
I
L
G
----
SVGEP
IN
P
E
AWEWY
W
KK
I
G
N
E
KCPVV
DT
WW
Q
TET
GGFM
I
T
P
L
--
-
-
PG
AT
E
LKA
G
S
A
T
R
P
F
FGV
Q
PA
LVD
N
EGN
PL
E
G
A
T
EG
S
LV
I
TD
S
WPG
Q
A
R
TLF
GDHERFE
QT
YF
--
-
-S
T
F
K
N
M
---
--
YFSGD
GA
RRDE
D
GY
YW
ITGR
VD
DV
L
N
VS
G
HR
L
G
TA
EIES
A
L
VA
HPKI
A
E
A
A
VVGIP
H
N
I
K
G
Q
AI
Y
AYV
T
LN
H
-
GE
E
P
S
P
E
L
Y
AE
VR
N
W
V
RK
E
I
GP
L
A
T
P
DV
L
HWT
D
S
LP
K
T
R
SGKI
MRRI
LR
fig|585034.5.peg.4176
Escherichia coli IAI1 (90-616/652)
GD
R
TAII
W
E
G
DD
AS
QSKH
I
SY
K
ELH
RDVC
R
F
AN
TL
L
E
LGIKKGD
V
VA
IY
M
P
MV
PE
A
A
V
AM
LACA
R
IGAV
H
SV
I
FGGFSP
E
A
V
A
G
R
I
ID
S
NS
R
L
VI
TS
--
-
-
-
-
---
-
--
--------
D
E
GVR
AG
R
S
I
P
L
KKN
VD
D
AL
KN
P
N
VT
SV
E
HVVV
LK
R
TGGKIDWQEGRDLWWHDLV
E
Q
A
SD
Q
HQ
A
EEM
N
A
E
D
P
L
F
IL
Y
TSG
S
TG
K
PKGVL
H
T
T
G
G
Y
L
----V
Y
A
A
-
L
TFK
YV
FDYHPG
D
I
Y
WCT
A
D
V
G
W
V
TG
HSYLLY
G
P
L
AC
GAT
T
LM
F
E
GV
PNWP
TP
A
R
MAQV
VDK
H
Q
V
N
----
I
L
YTA
P
TA
IR
A
LM
A
EG
DK
A
IEGTD
R
-
S
S
LR
I
L
G
----
SVGEP
IN
P
E
AWEWY
W
KK
I
G
N
E
KCPVV
DT
WW
Q
TET
GGFM
I
T
P
L
--
-
-
PG
AT
E
LKA
G
S
A
T
R
P
F
FGV
Q
PA
LVD
N
EGN
PL
E
G
A
T
EG
S
LV
I
TD
S
WPG
Q
A
R
TLF
GDHERFE
QT
YF
--
-
-S
T
F
K
N
M
---
--
YFSGD
GA
RRDE
D
GY
YW
ITGR
VD
DV
L
N
VS
G
HR
L
G
TA
EIES
A
L
VA
HPKI
A
E
A
A
VVGIP
H
N
I
K
G
Q
AI
Y
AYV
T
LN
H
-
GE
E
P
S
P
E
L
Y
AE
VR
N
W
V
RK
E
I
GP
L
A
T
P
DV
L
HWT
D
S
LP
K
T
R
SGKI
MRRI
LR
fig|83333.1.peg.3979
Escherichia coli K12 (90-616/652)
GD
R
TAII
W
E
G
DD
AS
QSKH
I
SY
K
ELH
RDVC
R
F
AN
TL
L
E
LGIKKGD
V
VA
IY
M
P
MV
PE
A
A
V
AM
LACA
R
IGAV
H
SV
I
FGGFSP
E
A
V
A
G
R
I
ID
S
NS
R
L
VI
TS
--
-
-
-
-
---
-
--
--------
D
E
GVR
AG
R
S
I
P
L
KKN
VD
D
AL
KN
P
N
VT
SV
E
HVVV
LK
R
TGGKIDWQEGRDLWWHDLV
E
Q
A
SD
Q
HQ
A
EEM
N
A
E
D
P
L
F
IL
Y
TSG
S
TG
K
PKGVL
H
T
T
G
G
Y
L
----V
Y
A
A
-
L
TFK
YV
FDYHPG
D
I
Y
WCT
A
D
V
G
W
V
TG
HSYLLY
G
P
L
AC
GAT
T
LM
F
E
GV
PNWP
TP
A
R
MAQV
VDK
H
Q
V
N
----
I
L
YTA
P
TA
IR
A
LM
A
EG
DK
A
IEGTD
R
-
S
S
LR
I
L
G
----
SVGEP
IN
P
E
AWEWY
W
KK
I
G
N
E
KCPVV
DT
WW
Q
TET
GGFM
I
T
P
L
--
-
-
PG
AT
E
LKA
G
S
A
T
R
P
F
FGV
Q
PA
LVD
N
EGN
PL
E
G
A
T
EG
S
LV
I
TD
S
WPG
Q
A
R
TLF
GDHERFE
QT
YF
--
-
-S
T
F
K
N
M
---
--
YFSGD
GA
RRDE
D
GY
YW
ITGR
VD
DV
L
N
VS
G
HR
L
G
TA
EIES
A
L
VA
HPKI
A
E
A
A
VVGIP
H
N
I
K
G
Q
AI
Y
AYV
T
LN
H
-
GE
E
P
S
P
E
L
Y
AE
VR
N
W
V
RK
E
I
GP
L
A
T
P
DV
L
HWT
D
S
LP
K
T
R
SGKI
MRRI
LR
fig|595495.4.peg.3127
Escherichia coli KO11 (90-616/652)
GD
R
TAII
W
E
G
DD
AS
QSKH
I
SY
K
ELH
RDVC
R
F
AN
TL
L
E
LGIKKGD
V
VA
IY
M
P
MV
PE
A
A
V
AM
LACA
R
IGAV
H
SV
I
FGGFSP
E
A
V
A
G
R
I
ID
S
NS
R
L
VI
TS
--
-
-
-
-
---
-
--
--------
D
E
GVR
AG
R
S
I
P
L
KKN
VD
D
AL
KN
P
N
VT
SV
E
HVVV
LK
R
TGGKIDWQEGRDLWWHDLV
E
Q
A
SD
Q
HQ
A
EEM
N
A
E
D
P
L
F
IL
Y
TSG
S
TG
K
PKGVL
H
T
T
G
G
Y
L
----V
Y
A
A
-
L
TFK
YV
FDYHPG
D
I
Y
WCT
A
D
V
G
W
V
TG
HSYLLY
G
P
L
AC
GAT
T
LM
F
E
GV
PNWP
TP
A
R
MAQV
VDK
H
Q
V
N
----
I
L
YTA
P
TA
IR
A
LM
A
EG
DK
A
IEGTD
R
-
S
S
LR
I
L
G
----
SVGEP
IN
P
E
AWEWY
W
KK
I
G
N
E
KCPVV
DT
WW
Q
TET
GGFM
I
T
P
L
--
-
-
PG
AT
E
LKA
G
S
A
T
R
P
F
FGV
Q
PA
LVD
N
EGN
PL
E
G
A
T
EG
S
LV
I
TD
S
WPG
Q
A
R
TLF
GDHERFE
QT
YF
--
-
-S
T
F
K
N
M
---
--
YFSGD
GA
RRDE
D
GY
YW
ITGR
VD
DV
L
N
VS
G
HR
L
G
TA
EIES
A
L
VA
HPKI
A
E
A
A
VVGIP
H
N
I
K
G
Q
AI
Y
AYV
T
LN
H
-
GE
E
P
S
P
E
L
Y
AE
VR
N
W
V
RK
E
I
GP
L
A
T
P
DV
L
HWT
D
S
LP
K
T
R
SGKI
MRRI
LR
fig|656417.3.peg.5145
Escherichia coli M605 (90-616/652)
GD
R
TAII
W
E
G
DD
AS
QSKH
I
SY
K
ELH
RDVC
R
F
AN
TL
L
E
LGIKKGD
V
VA
IY
M
P
MV
PE
A
A
V
AM
LACA
R
IGAV
H
SV
I
FGGFSP
E
A
V
A
G
R
I
ID
S
S
S
R
L
VI
TS
--
-
-
-
-
---
-
--
--------
D
E
GVR
AG
R
S
I
P
L
KKN
VD
D
AL
KN
P
N
VT
SV
E
HVVV
LK
R
TGGKIDWQEGRDLWWHDLV
E
Q
A
SD
Q
HQ
A
EEM
N
A
E
D
P
L
F
IL
Y
TSG
S
TG
K
PKGVL
H
T
T
G
G
Y
L
----V
Y
A
A
-
L
TFK
YV
FDYHPG
D
I
Y
WCT
A
D
V
G
W
V
TG
HSYLLY
G
P
L
AC
GAT
T
LM
F
E
GV
PNWP
TP
A
R
MAQV
VDK
H
Q
V
N
----
I
L
YTA
P
TA
IR
A
LM
A
EG
DK
A
IEGTD
R
-
S
S
LR
I
L
G
----
SVGEP
IN
P
E
AWEWY
W
KK
I
G
N
E
KCPVV
DT
WW
Q
TET
GGFM
I
T
P
L
--
-
-
PG
AT
E
LKA
G
S
A
T
R
P
F
FGV
Q
PA
LVD
N
EGN
PL
K
G
A
T
EG
S
LV
I
TD
S
WPG
Q
A
R
TLF
GDHERFE
QT
YF
--
-
-S
T
F
K
N
M
---
--
YFSGD
GA
RRDE
D
GY
YW
ITGR
VD
DV
L
N
VS
G
HR
L
G
TA
EIES
A
L
VA
HPKI
A
E
A
A
VVGIP
H
N
I
K
G
Q
AI
Y
AYV
T
LN
H
-
GE
E
P
S
P
E
L
Y
AE
VR
N
W
V
RK
E
I
GP
L
A
T
P
DV
L
HWT
D
S
LP
K
T
R
SGKI
MRRI
LR
fig|656419.3.peg.5306
Escherichia coli M718 (90-616/652)
GD
R
TAII
W
E
G
DD
AS
QSKH
I
SY
K
ELH
RDVC
R
F
AN
TL
L
E
LGIKKGD
V
VA
IY
M
P
MV
PE
A
A
V
AM
LACA
R
IGAV
H
SV
I
FGGFSP
E
A
V
A
G
R
I
ID
S
NS
R
L
VI
TS
--
-
-
-
-
---
-
--
--------
D
E
GVR
AG
R
S
I
P
L
KKN
VD
D
AL
KN
P
N
VT
SV
E
HVVV
LK
R
TGGKIDWQEGRDLWWHDLV
E
Q
A
SD
Q
HQ
A
EEM
N
A
E
D
P
L
F
IL
Y
TSG
S
TG
K
PKGVL
H
T
T
G
G
Y
L
----V
Y
A
A
-
L
TFK
YV
FDYHPG
D
I
Y
WCT
A
D
V
G
W
V
TG
HSYLLY
G
P
L
AC
GAT
T
LM
F
E
GV
PNWP
TP
A
R
MAQV
VDK
H
Q
V
N
----
I
L
YTA
P
TA
IR
A
LM
A
EG
DK
A
IEGTD
R
-
S
S
LR
I
L
G
----
SVGEP
IN
P
E
AWEWY
W
KK
I
G
N
E
KCPVV
DT
WW
Q
TET
GGFM
I
T
P
L
--
-
-
PG
AT
E
LKA
G
S
A
T
R
P
F
FGV
Q
PA
LVD
N
EGN
PL
E
G
A
T
EG
S
LV
I
TD
S
WPG
Q
A
R
TLF
GDHERFE
QT
YF
--
-
-S
T
F
K
N
M
---
--
YFSGD
GA
RRDE
D
GY
YW
ITGR
VD
DV
L
N
VS
G
HR
L
G
TA
EIES
A
L
VA
HPKI
A
E
A
A
VVGIP
H
N
I
K
G
Q
AI
Y
AYV
T
LN
H
-
GE
E
P
S
P
E
L
Y
AE
VR
N
W
V
RK
E
I
GP
L
A
T
P
DV
L
HWT
D
S
LP
K
T
R
SGKI
MRRI
LR
fig|679207.4.peg.2958
Escherichia coli MS 107-1 (90-616/652)
GD
R
TAII
W
E
G
DD
AS
QSKH
I
SY
K
ELH
RDVC
R
F
AN
TL
L
E
LGIKKGD
V
VA
IY
M
P
MV
PE
A
A
V
AM
LACA
R
IGAV
H
SV
I
FGGFSP
E
A
V
A
G
R
I
ID
S
NS
R
L
VI
TS
--
-
-
-
-
---
-
--
--------
D
E
GVR
AG
R
S
I
P
L
KKN
VD
D
AL
KN
P
N
VT
SV
E
HVVV
LK
R
TGGKIDWQEGRDLWWHDLV
E
Q
A
SD
Q
HQ
A
EEM
N
A
E
D
P
L
F
IL
Y
TSG
S
TG
K
PKGVL
H
T
T
G
G
Y
L
----V
Y
A
A
-
L
TFK
YV
FDYHPG
D
I
Y
WCT
A
D
V
G
W
V
TG
HSYLLY
G
P
L
AC
GAT
T
LM
F
E
GV
PNWP
TP
A
R
MAQV
VDK
H
Q
V
N
----
I
L
YTA
P
TA
IR
A
LM
A
EG
DK
A
IEGTD
R
-
S
S
LR
I
L
G
----
SVGEP
IN
P
E
AWEWY
W
KK
I
G
N
E
KCPVV
DT
WW
Q
TET
GGFM
I
T
P
L
--
-
-
PG
AT
E
LKA
G
S
A
T
R
P
F
FGV
Q
PA
LVD
N
EGN
PL
E
G
A
T
EG
S
LV
I
TD
S
WPG
Q
A
R
TLF
GDHERFE
QT
YF
--
-
-S
T
F
K
N
M
---
--
YFSGD
GA
RRDE
D
GY
YW
ITGR
VD
DV
L
N
VS
G
HR
L
G
TA
EIES
A
L
VA
HPKI
A
E
A
A
VVGIP
H
N
I
K
G
Q
AI
Y
AYV
T
LN
H
-
GE
E
P
S
P
E
L
Y
AE
VR
N
W
V
RK
E
I
GP
L
A
T
P
DV
L
HWT
D
S
LP
K
T
R
SGKI
MRRI
LR
fig|749537.3.peg.761
Escherichia coli MS 115-1 (90-616/652)
GD
R
TAII
W
E
G
DD
AS
QSKH
I
SY
K
ELH
RDVC
R
F
AN
TL
L
E
LGIKKGD
V
VA
IY
M
P
MV
PE
A
A
V
AM
LACA
R
IGAV
H
SV
I
FGGFSP
E
A
V
A
G
R
I
ID
S
NS
R
L
VI
TS
--
-
-
-
-
---
-
--
--------
D
E
GVR
AG
R
S
I
P
L
KKN
VD
D
AL
KN
P
N
VT
SV
E
HVVV
LK
R
TGGKIDWQEGRDLWWHDLV
E
Q
A
SD
Q
HQ
A
EEM
N
A
E
D
P
L
F
IL
Y
TSG
S
TG
K
PKGVL
H
T
T
G
G
Y
L
----V
Y
A
A
-
L
TFK
YV
FDYHPG
D
I
Y
WCT
A
D
V
G
W
V
TG
HSYLLY
G
P
L
AC
GAT
T
LM
F
E
GV
PNWP
TP
A
R
MAQV
VDK
H
Q
V
N
----
I
L
YTA
P
TA
IR
A
LM
A
EG
DK
A
IEGTD
R
-
S
S
LR
I
L
G
----
SVGEP
IN
P
E
AWEWY
W
KK
I
G
N
E
KCPVV
DT
WW
Q
TET
GGFM
I
T
P
L
--
-
-
PG
AT
E
LKA
G
S
A
T
R
P
F
FGV
Q
PA
LVD
N
EGN
PL
E
G
A
T
EG
S
LV
I
TD
S
WPG
Q
A
R
TLF
GDHERFE
QT
YF
--
-
-S
T
F
K
N
M
---
--
YFSGD
GA
RRDE
D
GY
YW
ITGR
VD
DV
L
N
VS
G
HR
L
G
TA
EIES
A
L
VA
HPKI
A
E
A
A
VVGIP
H
N
I
K
G
Q
AI
Y
AYV
T
LN
H
-
GE
E
P
S
P
E
L
Y
AE
VR
N
W
V
RK
E
I
GP
L
A
T
P
DV
L
HWT
D
S
LP
K
T
R
SGKI
MRRI
LR
fig|749538.3.peg.275
Escherichia coli MS 116-1 (90-616/652)
GD
R
TAII
W
E
G
DD
AS
QSKH
I
SY
K
ELH
RDVC
R
F
AN
TL
L
E
LGIKKGD
V
VA
IY
M
P
MV
PE
A
A
V
AM
LACA
R
IGAV
H
SV
I
FGGFSP
E
A
V
A
G
R
I
ID
S
NS
R
L
VI
TS
--
-
-
-
-
---
-
--
--------
D
E
GVR
AG
R
S
I
P
L
KKN
VD
D
AL
KN
P
N
VT
SV
E
HVVV
LK
R
TGGKIDWQEGRDLWWHDLV
E
Q
A
SD
Q
HQ
A
EEM
N
A
E
D
P
L
F
IL
Y
TSG
S
TG
K
PKGVL
H
T
T
G
G
Y
L
----V
Y
A
A
-
L
TFK
YV
FDYHPG
D
I
Y
WCT
A
D
V
G
W
V
TG
HSYLLY
G
P
L
AC
GAT
T
LM
F
E
GV
PNWP
TP
A
R
MAQV
VDK
H
Q
V
N
----
I
L
YTA
P
TA
IR
A
LM
A
EG
DK
A
IEGTD
R
-
S
S
LR
I
L
G
----
SVGEP
IN
P
E
AWEWY
W
KK
I
G
N
E
KCPVV
DT
WW
Q
TET
GGFM
I
T
P
L
--
-
-
PG
AT
E
LKA
G
S
A
T
R
P
F
FGV
Q
PA
LVD
N
EGN
PL
E
G
A
T
EG
S
LV
I
TD
S
WPG
Q
A
R
TLF
GDHERFE
QT
YF
--
-
-S
T
F
K
N
M
---
--
YFSGD
GA
RRDE
D
GY
YW
ITGR
VD
DV
L
N
VS
G
HR
L
G
TA
EIES
A
L
VA
HPKI
A
E
A
A
VVGIP
H
N
I
K
G
Q
AI
Y
AYV
T
LN
H
-
GE
E
P
S
P
E
L
Y
AE
VR
N
W
V
RK
E
I
GP
L
A
T
P
DV
L
HWT
D
S
LP
K
T
R
SGKI
MRRI
LR
fig|679206.4.peg.4422
Escherichia coli MS 119-7 (90-616/652)
GD
R
TAII
W
E
G
DD
AS
QSKH
I
SY
K
ELH
RDVC
R
F
AN
TL
L
E
LGIKKGD
V
VA
IY
M
P
MV
PE
A
A
V
AM
LACA
R
IGAV
H
SV
I
FGGFSP
E
A
V
A
G
R
I
ID
S
NS
R
L
VI
TS
--
-
-
-
-
---
-
--
--------
D
E
GVR
AG
R
S
I
P
L
KKN
VD
D
AL
KN
P
N
VT
SV
E
HVVV
LK
R
TGGKIDWQEGRDLWWHDLV
E
Q
A
SD
Q
HQ
A
EEM
N
A
E
D
P
L
F
IL
Y
TSG
S
TG
K
PKGVL
H
T
T
G
G
Y
L
----V
Y
A
A
-
L
TFK
YV
FDYHPG
D
I
Y
WCT
A
D
V
G
W
V
TG
HSYLLY
G
P
L
AC
GAT
T
LM
F
E
GV
PNWP
TP
A
R
MAQV
VDK
H
Q
V
N
----
I
L
YTA
P
TA
IR
A
LM
A
EG
DK
A
IEGTD
R
-
S
S
LR
I
L
G
----
SVGEP
IN
P
E
AWEWY
W
KK
I
G
N
E
KCPVV
DT
WW
Q
TET
GGFM
I
T
P
L
--
-
-
PG
AT
E
LKA
G
S
A
T
R
P
F
FGV
Q
PA
LVD
N
EGN
PL
E
G
A
T
EG
S
LV
I
TD
S
WPG
Q
A
R
TLF
GDHERFE
QT
YF
--
-
-S
T
F
K
N
M
---
--
YFSGD
GA
RRDE
D
GY
YW
ITGR
VD
DV
L
N
VS
G
HR
L
G
TA
EIES
A
L
VA
HPKI
A
E
A
A
VVGIP
H
N
I
K
G
Q
AI
Y
AYV
T
LN
H
-
GE
E
P
S
P
E
L
Y
AE
VR
N
W
V
RK
E
I
GP
L
A
T
P
DV
L
HWT
D
S
LP
K
T
R
SGKI
MRRI
LR
fig|679205.4.peg.1276
Escherichia coli MS 124-1 (90-616/652)
GD
R
TAII
W
E
G
DD
AS
QSKH
I
SY
K
ELH
RDVC
R
F
AN
TL
L
E
LGIKKGD
V
VA
IY
M
P
MV
PE
A
A
V
AM
LACA
R
IGAV
H
SV
I
FGGFSP
E
A
V
A
G
R
I
ID
S
NS
R
L
VI
TS
--
-
-
-
-
---
-
--
--------
D
E
GVR
AG
R
S
I
P
L
KKN
VD
D
AL
KN
P
N
VT
SV
E
HVVV
LK
R
TGGKIDWQEGRDLWWHDLV
E
Q
A
SD
Q
HQ
A
EEM
N
A
E
D
P
L
F
IL
Y
TSG
S
TG
K
PKGVL
H
T
T
G
G
Y
L
----V
Y
A
A
-
L
TFK
YV
FDYHPG
D
I
Y
WCT
A
D
V
G
W
V
TG
HSYLLY
G
P
L
AC
GAT
T
LM
F
E
GV
PNWP
TP
A
R
MAQV
VDK
H
Q
V
N
----
I
L
YTA
P
TA
IR
A
LM
A
EG
DK
A
IEGTD
R
-
S
S
LR
I
L
G
----
SVGEP
IN
P
E
AWEWY
W
KK
I
G
N
E
KCPVV
DT
WW
Q
TET
GGFM
I
T
P
L
--
-
-
PG
AT
E
LKA
G
S
A
T
R
P
F
FGV
Q
PA
LVD
N
EGN
PL
E
G
A
T
EG
S
LV
I
TD
S
WPG
Q
A
R
TLF
GDHERFE
QT
YF
--
-
-S
T
F
K
N
M
---
--
YFSGD
GA
RRDE
D
GY
YW
ITGR
VD
DV
L
N
VS
G
HR
L
G
TA
EIES
A
L
VA
HPKI
A
E
A
A
VVGIP
H
N
I
K
G
Q
AI
Y
AYV
T
LN
H
-
GE
E
P
S
P
E
L
Y
AE
VR
N
W
V
RK
E
I
GP
L
A
T
P
DV
L
HWT
D
S
LP
K
T
R
SGKI
MRRI
LR
fig|679204.3.peg.3007
Escherichia coli MS 145-7 (90-616/652)
GD
R
TAII
W
E
G
DD
AS
QSKH
I
SY
K
ELH
RDVC
R
F
AN
TL
L
E
LGIKKGD
V
VA
IY
M
P
MV
PE
A
A
V
AM
LACA
R
IGAV
H
SV
I
FGGFSP
E
A
V
A
G
R
I
ID
S
NS
R
L
VI
TS
--
-
-
-
-
---
-
--
--------
D
E
GVR
AG
R
S
I
P
L
KKN
VD
D
AL
KN
P
N
VT
SV
E
HVVV
LK
R
TGGKIDWQEGRDLWWHDLV
E
Q
A
SD
Q
HQ
A
EEM
N
A
E
D
P
L
F
IL
Y
TSG
S
TG
K
PKGVL
H
T
T
G
G
Y
L
----V
Y
A
A
-
L
TFK
YV
FDYHPG
D
I
Y
WCT
A
D
V
G
W
V
TG
HSYLLY
G
P
L
AC
GAT
T
LM
F
E
GV
PNWP
TP
A
R
MAQV
VDK
H
Q
V
N
----
I
L
YTA
P
TA
IR
A
LM
A
EG
DK
A
IEGTD
R
-
S
S
LR
I
L
G
----
SVGEP
IN
P
E
AWEWY
W
KK
I
G
N
E
KCPVV
DT
WW
Q
TET
GGFM
I
T
P
L
--
-
-
PG
AT
E
LKA
G
S
A
T
R
P
F
FGV
Q
PA
LVD
N
EGN
PL
E
G
A
T
EG
S
LV
I
TD
S
WPG
Q
A
R
TLF
GDHERFE
QT
YF
--
-
-S
T
F
K
N
M
---
--
YFSGD
GA
RRDE
D
GY
YW
ITGR
VD
DV
L
N
VS
G
HR
L
G
TA
EIES
A
L
VA
HPKI
A
E
A
A
VVGIP
H
N
I
K
G
Q
AI
Y
AYV
T
LN
H
-
GE
E
P
S
P
E
L
Y
AE
VR
N
W
V
RK
E
I
GP
L
A
T
P
DV
L
HWT
D
S
LP
K
T
R
SGKI
MRRI
LR
fig|749540.3.peg.1630
Escherichia coli MS 146-1 (90-616/652)
GD
R
TAII
W
E
G
DD
AS
QSKH
I
SY
K
ELH
RDVC
R
F
AN
TL
L
E
LGIKKGD
V
VA
IY
M
P
MV
PE
A
A
V
AM
LACA
R
IGAV
H
SV
I
FGGFSP
E
A
V
A
G
R
I
ID
S
NS
R
L
VI
TS
--
-
-
-
-
---
-
--
--------
D
E
GVR
AG
R
S
I
P
L
KKN
VD
D
AL
KN
P
N
VT
SV
E
HVVV
LK
R
TGGKIDWQEGRDLWWHDLV
E
Q
A
SD
Q
HQ
A
EEM
N
A
E
D
P
L
F
IL
Y
TSG
S
TG
K
PKGVL
H
T
T
G
G
Y
L
----V
Y
A
A
-
L
TFK
YV
FDYHPG
D
I
Y
WCT
A
D
V
G
W
V
TG
HSYLLY
G
P
L
AC
GAT
T
LM
F
E
GV
PNWP
TP
A
R
MAQV
VDK
H
Q
V
N
----
I
L
YTA
P
TA
IR
A
LM
A
EG
DK
A
IEGTD
R
-
S
S
LR
I
L
G
----
SVGEP
IN
P
E
AWEWY
W
KK
I
G
N
E
KCPVV
DT
WW
Q
TET
GGFM
I
T
P
L
--
-
-
PG
AT
E
LKA
G
S
A
T
R
P
F
FGV
Q
PA
LVD
N
EGN
PL
E
G
A
T
EG
S
LV
I
TD
S
WPG
Q
A
R
TLF
GDHERFE
QT
YF
--
-
-S
T
F
K
N
M
---
--
YFSGD
GA
RRDE
D
GY
YW
ITGR
VD
DV
L
N
VS
G
HR
L
G
TA
EIES
A
L
VA
HPKI
A
E
A
A
VVGIP
H
N
I
K
G
Q
AI
Y
AYV
T
LN
H
-
GE
E
P
S
P
E
L
Y
AE
VR
N
W
V
RK
E
I
GP
L
A
T
P
DV
L
HWT
D
S
LP
K
T
R
SGKI
MRRI
LR
fig|749544.3.peg.3141
Escherichia coli MS 175-1 (90-616/652)
GD
R
TAII
W
E
G
DD
AS
QSKH
I
SY
K
ELH
RDVC
R
F
AN
TL
L
E
LGIKKGD
V
VA
IY
M
P
MV
PE
A
A
V
AM
LACA
R
IGAV
H
SV
I
FGGFSP
E
A
V
A
G
R
I
ID
S
NS
R
L
VI
TS
--
-
-
-
-
---
-
--
--------
D
E
GVR
AG
R
S
I
P
L
KKN
VD
D
AL
KN
P
N
VT
SV
E
HVVV
LK
R
TGGKIDWQEGRDLWWHDLV
E
Q
A
SD
Q
HQ
A
EEM
N
A
E
D
P
L
F
IL
Y
TSG
S
TG
K
PKGVL
H
T
T
G
G
Y
L
----V
Y
A
A
-
L
TFK
YV
FDYHPG
D
I
Y
WCT
A
D
V
G
W
V
TG
HSYLLY
G
P
L
AC
GAT
T
LM
F
E
GV
PNWP
TP
A
R
MAQV
VDK
H
Q
V
N
----
I
L
YTA
P
TA
IR
A
LM
A
EG
DK
A
IEGTD
R
-
S
S
LR
I
L
G
----
SVGEP
IN
P
E
AWEWY
W
KK
I
G
N
E
KCPVV
DT
WW
Q
TET
GGFM
I
T
P
L
--
-
-
PG
AT
E
LKA
G
S
A
T
R
P
F
FGV
Q
PA
LVD
N
EGN
PL
E
G
A
T
EG
S
LV
I
TD
S
WPG
Q
A
R
TLF
GDHERFE
QT
YF
--
-
-S
T
F
K
N
M
---
--
YFSGD
GA
RRDE
D
GY
YW
ITGR
VD
DV
L
N
VS
G
HR
L
G
TA
EIES
A
L
VA
HPKI
A
E
A
A
VVGIP
H
N
I
K
G
Q
AI
Y
AYV
T
LN
H
-
GE
E
P
S
P
E
L
Y
AE
VR
N
W
V
RK
E
I
GP
L
A
T
P
DV
L
HWT
D
S
LP
K
T
R
SGKI
MRRI
LR
fig|749545.3.peg.2373
Escherichia coli MS 182-1 (90-616/652)
GD
R
TAII
W
E
G
DD
AS
QSKH
I
SY
K
ELH
RDVC
R
F
AN
TL
L
E
LGIKKGD
V
VA
IY
M
P
MV
PE
A
A
V
AM
LACA
R
IGAV
H
SV
I
FGGFSP
E
A
V
A
G
R
I
ID
S
NS
R
L
VI
TS
--
-
-
-
-
---
-
--
--------
D
E
GVR
AG
R
S
I
P
L
KKN
VD
D
AL
KN
P
N
VT
SV
E
HVVV
LK
R
TGGKIDWQEGRDLWWHDLV
E
Q
A
SD
Q
HQ
A
EEM
N
A
E
D
P
L
F
IL
Y
TSG
S
TG
K
PKGVL
H
T
T
G
G
Y
L
----V
Y
A
A
-
L
TFK
YV
FDYHPG
D
I
Y
WCT
A
D
V
G
W
V
TG
HSYLLY
G
P
L
AC
GAT
T
LM
F
E
GV
PNWP
TP
A
R
MAQV
VDK
H
Q
V
N
----
I
L
YTA
P
TA
IR
A
LM
A
EG
DK
A
IEGTD
R
-
S
S
LR
I
L
G
----
SVGEP
IN
P
E
AWEWY
W
KK
I
G
N
E
KCPVV
DT
WW
Q
TET
GGFM
I
T
P
L
--
-
-
PG
AT
E
LKA
G
S
A
T
R
P
F
FGV
Q
PA
LVD
N
EGN
PL
E
G
A
T
EG
S
LV
I
TD
S
WPG
Q
A
R
TLF
GDHERFE
QT
YF
--
-
-S
T
F
K
N
M
---
--
YFSGD
GA
RRDE
D
GY
YW
ITGR
VD
DV
L
N
VS
G
HR
L
G
TA
EIES
A
L
VA
HPKI
A
E
A
A
VVGIP
H
N
I
K
G
Q
AI
Y
AYV
T
LN
H
-
GE
E
P
S
P
E
L
Y
AE
VR
N
W
V
RK
E
I
GP
L
A
T
P
DV
L
HWT
D
S
LP
K
T
R
SGKI
MRRI
LR
fig|749547.3.peg.2679
Escherichia coli MS 187-1 (90-616/652)
GD
R
TAII
W
E
G
DD
AS
QSKH
I
SY
K
ELH
RDVC
R
F
AN
TL
L
E
LGIKKGD
V
VA
IY
M
P
MV
PE
A
A
V
AM
LACA
R
IGAV
H
SV
I
FGGFSP
E
A
V
A
G
R
I
ID
S
NS
R
L
VI
TS
--
-
-
-
-
---
-
--
--------
D
E
GVR
AG
R
S
I
P
L
KKN
VD
D
AL
KN
P
N
VT
SV
E
HVVV
LK
R
TGGKIDWQEGRDLWWHDLV
E
Q
A
SD
Q
HQ
A
EEM
N
A
E
D
P
L
F
IL
Y
TSG
S
TG
K
PKGVL
H
T
T
G
G
Y
L
----V
Y
A
A
-
L
TFK
YV
FDYHPG
D
I
Y
WCT
A
D
V
G
W
V
TG
HSYLLY
G
P
L
AC
GAT
T
LM
F
E
GV
PNWP
TP
A
R
MAQV
VDK
H
Q
V
N
----
I
L
YTA
P
TA
IR
A
LM
A
EG
DK
A
IEGTD
R
-
S
S
LR
I
L
G
----
SVGEP
IN
P
E
AWEWY
W
KK
I
G
N
E
KCPVV
DT
WW
Q
TET
GGFM
I
T
P
L
--
-
-
PG
AT
E
LKA
G
S
A
T
R
P
F
FGV
Q
PA
LVD
N
EGN
PL
E
G
A
T
EG
S
LV
I
TD
S
WPG
Q
A
R
TLF
GDHERFE
QT
YF
--
-
-S
T
F
K
N
M
---
--
YFSGD
GA
RRDE
D
GY
YW
ITGR
VD
DV
L
N
VS
G
HR
L
G
TA
EIES
A
L
VA
HPKI
A
E
A
A
VVGIP
H
N
I
K
G
Q
AI
Y
AYV
T
LN
H
-
GE
E
P
S
P
E
L
Y
AE
VR
N
W
V
RK
E
I
GP
L
A
T
P
DV
L
HWT
D
S
LP
K
T
R
SGKI
MRRI
LR
fig|749548.3.peg.384
Escherichia coli MS 196-1 (90-616/652)
GD
R
TAII
W
E
G
DD
AS
QSKH
I
SY
K
ELH
RDVC
R
F
AN
TL
L
E
LGIKKGD
V
VA
IY
M
P
MV
PE
A
A
V
AM
LACA
R
IGAV
H
SV
I
FGGFSP
E
A
V
A
G
R
I
ID
S
NS
R
L
VI
TS
--
-
-
-
-
---
-
--
--------
D
E
GVR
AG
R
S
I
P
L
KKN
VD
D
AL
KN
P
N
VT
SV
E
HVVV
LK
R
TGGKIDWQEGRDLWWHDLV
E
Q
A
SD
Q
HQ
A
EEM
N
A
E
D
P
L
F
IL
Y
TSG
S
TG
K
PKGVL
H
T
T
G
G
Y
L
----V
Y
A
A
-
L
TFK
YV
FDYHPG
D
I
Y
WCT
A
D
V
G
W
V
TG
HSYLLY
G
P
L
AC
GAT
T
LM
F
E
GV
PNWP
TP
A
R
MAQV
VDK
H
Q
V
N
----
I
L
YTA
P
TA
IR
A
LM
A
EG
DK
A
IEGTD
R
-
S
S
LR
I
L
G
----
SVGEP
IN
P
E
AWEWY
W
KK
I
G
N
E
KCPVV
DT
WW
Q
TET
GGFM
I
T
P
L
--
-
-
PG
AT
E
LKA
G
S
A
T
R
P
F
FGV
Q
PA
LVD
N
EGN
PL
E
G
A
T
EG
S
LV
I
TD
S
WPG
Q
A
R
TLF
GDHERFE
QT
YF
--
-
-S
T
F
K
N
M
---
--
YFSGD
GA
RRDE
D
GY
YW
ITGR
VD
DV
L
N
VS
G
HR
L
G
TA
EIES
A
L
VA
HPKI
A
E
A
A
VVGIP
H
N
I
K
G
Q
AI
Y
AYV
T
LN
H
-
GE
E
P
S
P
E
L
Y
AE
VR
N
W
V
RK
E
I
GP
L
A
T
P
DV
L
HWT
D
S
LP
K
T
R
SGKI
MRRI
LR
fig|749532.3.peg.4624
Escherichia coli MS 78-1 (90-616/652)
GD
R
TAII
W
E
G
DD
AS
QSKH
I
SY
K
ELH
RDVC
R
F
AN
TL
L
E
LGIKKGD
V
VA
IY
M
P
MV
PE
A
A
V
AM
LACA
R
IGAV
H
SV
I
FGGFSP
E
A
V
A
G
R
I
ID
S
NS
R
L
VI
TS
--
-
-
-
-
---
-
--
--------
D
E
GVR
AG
R
S
I
P
L
KKN
VD
D
AL
KN
P
N
VT
SV
E
HVVV
LK
R
TGGKIDWQEGRDLWWHDLV
E
Q
A
SD
Q
HQ
A
EEM
N
A
E
D
P
L
F
IL
Y
TSG
S
TG
K
PKGVL
H
T
T
G
G
Y
L
----V
Y
A
A
-
L
TFK
YV
FDYHPG
D
I
Y
WCT
A
D
V
G
W
V
TG
HSYLLY
G
P
L
AC
GAT
T
LM
F
E
GV
PNWP
TP
A
R
MAQV
VDK
H
Q
V
N
----
I
L
YTA
P
TA
IR
A
LM
A
EG
DK
A
IEGTD
R
-
S
S
LR
I
L
G
----
SVGEP
IN
P
E
AWEWY
W
KK
I
G
N
E
KCPVV
DT
WW
Q
TET
GGFM
I
T
P
L
--
-
-
PG
AT
E
LKA
G
S
A
T
R
P
F
FGV
Q
PA
LVD
N
EGN
PL
E
G
A
T
EG
S
LV
I
TD
S
WPG
Q
A
R
TLF
GDHERFE
QT
YF
--
-
-S
T
F
K
N
M
---
--
YFSGD
GA
RRDE
D
GY
YW
ITGR
VD
DV
L
N
VS
G
HR
L
G
TA
EIES
A
L
VA
HPKI
A
E
A
A
VVGIP
H
N
I
K
G
Q
AI
Y
AYV
T
LN
H
-
GE
E
P
S
P
E
L
Y
AE
VR
N
W
V
RK
E
I
GP
L
A
T
P
DV
L
HWT
D
S
LP
K
T
R
SGKI
MRRI
LR
fig|749533.3.peg.4305
Escherichia coli MS 84-1 (90-616/652)
GD
R
TAII
W
E
G
DD
AS
QSKH
I
SY
K
ELH
RDVC
R
F
AN
TL
L
E
LGIKKGD
V
VA
IY
M
P
MV
PE
A
A
V
AM
LACA
R
IGAV
H
SV
I
FGGFSP
E
A
V
A
G
R
I
ID
S
NS
R
L
VI
TS
--
-
-
-
-
---
-
--
--------
D
E
GVR
AG
R
S
I
P
L
KKN
VD
D
AL
KN
P
N
VT
SV
E
HVVV
LK
R
TGGKIDWQEGRDLWWHDLV
E
Q
A
SD
Q
HQ
A
EEM
N
A
E
D
P
L
F
IL
Y
TSG
S
TG
K
PKGVL
H
T
T
G
G
Y
L
----V
Y
A
A
-
L
TFK
YV
FDYHPG
D
I
Y
WCT
A
D
V
G
W
V
TG
HSYLLY
G
P
L
AC
GAT
T
LM
F
E
GV
PNWP
TP
A
R
MAQV
VDK
H
Q
V
N
----
I
L
YTA
P
TA
IR
A
LM
A
EG
DK
A
IEGTD
R
-
S
S
LR
I
L
G
----
SVGEP
IN
P
E
AWEWY
W
KK
I
G
N
E
KCPVV
DT
WW
Q
TET
GGFM
I
T
P
L
--
-
-
PG
AT
E
LKA
G
S
A
T
R
P
F
FGV
Q
PA
LVD
N
EGN
PL
E
G
A
T
EG
S
LV
I
TD
S
WPG
Q
A
R
TLF
GDHERFE
QT
YF
--
-
-S
T
F
K
N
M
---
--
YFSGD
GA
RRDE
D
GY
YW
ITGR
VD
DV
L
N
VS
G
HR
L
G
TA
EIES
A
L
VA
HPKI
A
E
A
A
VVGIP
H
N
I
K
G
Q
AI
Y
AYV
T
LN
H
-
GE
E
P
S
P
E
L
Y
AE
VR
N
W
V
RK
E
I
GP
L
A
T
P
DV
L
HWT
D
S
LP
K
T
R
SGKI
MRRI
LR
fig|585395.4.peg.5060
Escherichia coli O103:H2 str. 12009 (90-616/652)
GD
R
TAII
W
E
G
DD
AS
QSKH
I
SY
K
ELH
RDVC
R
F
AN
TL
L
E
LGIKKGD
V
VA
IY
M
P
MV
PE
A
A
V
AM
LACA
R
IGAV
H
SV
I
FGGFSP
E
A
V
A
G
R
I
ID
S
NS
R
L
VI
TS
--
-
-
-
-
---
-
--
--------
D
E
GVR
AG
R
S
I
P
L
KKN
VD
D
AL
KN
P
N
VT
SV
E
HVVV
LK
R
TGGKIDWQEGRDLWWHDLV
E
Q
A
SD
Q
HQ
A
EEM
N
A
E
D
P
L
F
IL
Y
TSG
S
TG
K
PKGVL
H
T
T
G
G
Y
L
----V
Y
A
A
-
L
TFK
YV
FDYHPG
D
I
Y
WCT
A
D
V
G
W
V
TG
HSYLLY
G
P
L
AC
GAT
T
LM
F
E
GV
PNWP
TP
A
R
MAQV
VDK
H
Q
V
N
----
I
L
YTA
P
TA
IR
A
LM
A
EG
DK
A
IEGTD
R
-
S
S
LR
I
L
G
----
SVGEP
IN
P
E
AWEWY
W
KK
I
G
N
E
KCPVV
DT
WW
Q
TET
GGFM
I
T
P
L
--
-
-
PG
AT
E
LKA
G
S
A
T
R
P
F
FGV
Q
PA
LVD
N
EGN
PL
E
G
A
T
EG
S
LV
I
TD
S
WPG
Q
A
R
TLF
GDHERFE
QT
YF
--
-
-S
T
F
K
N
M
---
--
YFSGD
GA
RRDE
D
GY
YW
ITGR
VD
DV
L
N
VS
G
HR
L
G
TA
EIES
A
L
VA
HPKI
A
E
A
A
VVGIP
H
N
I
K
G
Q
AI
Y
AYV
T
LN
H
-
GE
E
P
S
P
E
L
Y
AE
VR
N
W
V
RK
E
I
GP
L
A
T
P
DV
L
HWT
D
S
LP
K
T
R
SGKI
MRRI
LR
fig|585396.4.peg.5148
Escherichia coli O111:H- str. 11128 (90-616/652)
GD
R
TAII
W
E
G
DD
AS
QSKH
I
SY
K
ELH
RDVC
R
F
AN
TL
L
E
LGIKKGD
V
VA
IY
M
P
MV
PE
A
A
V
AM
LACA
R
IGAV
H
SV
I
FGGFSP
E
A
V
A
G
R
I
ID
S
NS
R
L
VI
TS
--
-
-
-
-
---
-
--
--------
D
E
GVR
AG
R
S
I
P
L
KKN
VD
D
AL
KN
P
N
VT
SV
E
HVVV
LK
R
TGGKIDWQEGRDLWWHDLV
E
Q
A
SD
Q
HQ
A
EEM
N
A
E
D
P
L
F
IL
Y
TSG
S
TG
K
PKGVL
H
T
T
G
G
Y
L
----V
Y
A
A
-
L
TFK
YV
FDYHPG
D
I
Y
WCT
A
D
V
G
W
V
TG
HSYLLY
G
P
L
AC
GAT
T
LM
F
E
GV
PNWP
TP
A
R
MAQV
VDK
H
Q
V
N
----
I
L
YTA
P
TA
IR
A
LM
A
EG
DK
A
IEGTD
R
-
S
S
LR
I
L
G
----
SVGEP
IN
P
E
AWEWY
W
KK
I
G
N
E
KCPVV
DT
WW
Q
TET
GGFM
I
T
P
L
--
-
-
PG
AT
E
LKA
G
S
A
T
R
P
F
FGV
Q
PA
LVD
N
EGN
PL
E
G
A
T
EG
S
LV
I
TD
S
WPG
Q
A
R
TLF
GDHERFE
QT
YF
--
-
-S
T
F
K
N
M
---
--
YFSGD
GA
RRDE
D
GY
YW
ITGR
VD
DV
L
N
VS
G
HR
L
G
TA
EIES
A
L
VA
HPKI
A
E
A
A
VVGIP
H
N
I
K
G
Q
AI
Y
AYV
T
LN
H
-
GE
E
P
S
P
E
L
Y
AE
VR
N
W
V
RK
E
I
GP
L
A
T
P
DV
L
HWT
D
S
LP
K
T
R
SGKI
MRRI
LR
fig|574521.7.peg.4492
Escherichia coli O127:H6 str. E2348/69 (90-616/652)
GD
R
TAII
W
E
G
DD
AS
QSKH
I
SY
K
ELH
RDVC
R
F
AN
TL
L
E
LGIKKGD
V
VA
IY
M
P
MV
PE
A
A
V
AM
LACA
R
IGAV
H
SV
I
FGGFSP
E
A
V
A
G
R
I
ID
S
NS
R
L
VI
TS
--
-
-
-
-
---
-
--
--------
D
E
GVR
AG
R
S
I
P
L
KKN
VD
D
AL
KN
P
N
VT
SV
E
HVVV
LK
R
TGGKIDWQEGRDLWWHDLV
E
Q
A
SD
Q
HQ
A
EEM
N
A
E
D
P
L
F
IL
Y
TSG
S
TG
K
PKGVL
H
T
T
G
G
Y
L
----V
Y
A
A
-
L
TFK
YV
FDYHPG
D
I
Y
WCT
A
D
V
G
W
V
TG
HSYLLY
G
P
L
AC
GAT
T
LM
F
E
GV
PNWP
TP
A
R
MAQV
VDK
H
Q
V
N
----
I
L
YTA
P
TA
IR
A
LM
A
EG
DK
A
IEGTD
R
-
S
S
LR
I
L
G
----
SVGEP
IN
P
E
AWEWY
W
KK
I
G
N
E
KCPVV
DT
WW
Q
TET
GGFM
I
T
P
L
--
-
-
PG
AT
E
LKA
G
S
A
T
R
P
F
FGV
Q
PA
LVD
N
EGN
PL
E
G
A
T
EG
S
LV
I
TD
S
WPG
Q
A
R
TLF
GDHERFE
QT
YF
--
-
-S
T
F
K
N
M
---
--
YFSGD
GA
RRDE
D
GY
YW
ITGR
VD
DV
L
N
VS
G
HR
L
G
TA
EIES
A
L
VA
HPKI
A
E
A
A
VVGIP
H
N
I
K
G
Q
AI
Y
AYV
T
LN
H
-
GE
E
P
S
P
E
L
Y
AE
VR
N
W
V
RK
E
I
GP
L
A
T
P
DV
L
HWT
D
S
LP
K
T
R
SGKI
MRRI
LR
fig|573235.3.peg.5355
Escherichia coli O26:H11 str. 11368 (90-616/652)
GD
R
TAII
W
E
G
DD
AS
QSKH
I
SY
K
ELH
RDVC
R
F
AN
TL
L
E
LGIKKGD
V
VA
IY
M
P
MV
PE
A
A
V
AM
LACA
R
IGAV
H
SV
I
FGGFSP
E
A
V
A
G
R
I
ID
S
NS
R
L
VI
TS
--
-
-
-
-
---
-
--
--------
D
E
GVR
AG
R
S
I
P
L
KKN
VD
D
AL
KN
P
N
VT
SV
E
HVVV
LK
R
TGGKIDWQEGRDLWWHDLV
E
Q
A
SD
Q
HQ
A
EEM
N
A
E
D
P
L
F
IL
Y
TSG
S
TG
K
PKGVL
H
T
T
G
G
Y
L
----V
Y
A
A
-
L
TFK
YV
FDYHPG
D
I
Y
WCT
A
D
V
G
W
V
TG
HSYLLY
G
P
L
AC
GAT
T
LM
F
E
GV
PNWP
TP
A
R
MAQV
VDK
H
Q
V
N
----
I
L
YTA
P
TA
IR
A
LM
A
EG
DK
A
IEGTD
R
-
S
S
LR
I
L
G
----
SVGEP
IN
P
E
AWEWY
W
KK
I
G
N
E
KCPVV
DT
WW
Q
TET
GGFM
I
T
P
L
--
-
-
PG
AT
E
LKA
G
S
A
T
R
P
F
FGV
Q
PA
LVD
N
EGN
PL
E
G
A
T
EG
S
LV
I
TD
S
WPG
Q
A
R
TLF
GDHERFE
QT
YF
--
-
-S
T
F
K
N
M
---
--
YFSGD
GA
RRDE
D
GY
YW
ITGR
VD
DV
L
N
VS
G
HR
L
G
TA
EIES
A
L
VA
HPKI
A
E
A
A
VVGIP
H
N
I
K
G
Q
AI
Y
AYV
T
LN
H
-
GE
E
P
S
P
E
L
Y
AE
VR
N
W
V
RK
E
I
GP
L
A
T
P
DV
L
HWT
D
S
LP
K
T
R
SGKI
MRRI
LR
fig|409438.11.peg.4546
Escherichia coli SE11 (90-616/652)
GD
R
TAII
W
E
G
DD
AS
QSKH
I
SY
K
ELH
RDVC
R
F
AN
TL
L
E
LGIKKGD
V
VA
IY
M
P
MV
PE
A
A
V
AM
LACA
R
IGAV
H
SV
I
FGGFSP
E
A
V
A
G
R
I
ID
S
NS
R
L
VI
TS
--
-
-
-
-
---
-
--
--------
D
E
GVR
AG
R
S
I
P
L
KKN
VD
D
AL
KN
P
N
VT
SV
E
HVVV
LK
R
TGGKIDWQEGRDLWWHDLV
E
Q
A
SD
Q
HQ
A
EEM
N
A
E
D
P
L
F
IL
Y
TSG
S
TG
K
PKGVL
H
T
T
G
G
Y
L
----V
Y
A
A
-
L
TFK
YV
FDYHPG
D
I
Y
WCT
A
D
V
G
W
V
TG
HSYLLY
G
P
L
AC
GAT
T
LM
F
E
GV
PNWP
TP
A
R
MAQV
VDK
H
Q
V
N
----
I
L
YTA
P
TA
IR
A
LM
A
EG
DK
A
IEGTD
R
-
S
S
LR
I
L
G
----
SVGEP
IN
P
E
AWEWY
W
KK
I
G
N
E
KCPVV
DT
WW
Q
TET
GGFM
I
T
P
L
--
-
-
PG
AT
E
LKA
G
S
A
T
R
P
F
FGV
Q
PA
LVD
N
EGN
PL
E
G
A
T
EG
S
LV
I
TD
S
WPG
Q
A
R
TLF
GDHERFE
QT
YF
--
-
-S
T
F
K
N
M
---
--
YFSGD
GA
RRDE
D
GY
YW
ITGR
VD
DV
L
N
VS
G
HR
L
G
TA
EIES
A
L
VA
HPKI
A
E
A
A
VVGIP
H
N
I
K
G
Q
AI
Y
AYV
T
LN
H
-
GE
E
P
S
P
E
L
Y
AE
VR
N
W
V
RK
E
I
GP
L
A
T
P
DV
L
HWT
D
S
LP
K
T
R
SGKI
MRRI
LR
fig|431946.3.peg.4102
Escherichia coli SE15 (90-616/652)
GD
R
TAII
W
E
G
DD
AS
QSKH
I
SY
K
ELH
RDVC
R
F
AN
TL
L
E
LGIKKGD
V
VA
IY
M
P
MV
PE
A
A
V
AM
LACA
R
IGAV
H
SV
I
FGGFSP
E
A
V
A
G
R
I
ID
S
S
S
R
L
VI
TS
--
-
-
-
-
---
-
--
--------
D
E
GVR
AG
R
S
I
P
L
KKN
VD
D
AL
KN
P
N
VT
SV
E
HVVV
LK
R
TGGKIDWQEGRDLWWHDLV
E
Q
A
SD
Q
HQ
A
EEM
N
A
E
D
P
L
F
IL
Y
TSG
S
TG
K
PKGVL
H
T
T
G
G
Y
L
----V
Y
A
A
-
L
TFK
YV
FDYHPG
D
I
Y
WCT
A
D
V
G
W
V
TG
HSYLLY
G
P
L
AC
GAT
T
LM
F
E
GV
PNWP
TP
A
R
MAQV
VDK
H
Q
V
N
----
I
L
YTA
P
TA
IR
A
LM
A
EG
DK
A
IEGTD
R
-
S
S
LR
I
L
G
----
SVGEP
IN
P
E
AWEWY
W
KK
I
G
N
E
KCPVV
DT
WW
Q
TET
GGFM
I
T
P
L
--
-
-
PG
AT
E
LKA
G
S
A
T
R
P
F
FGV
Q
PA
LVD
N
EGN
PL
K
G
A
T
EG
S
LV
I
TD
S
WPG
Q
A
R
TLF
GDHERFE
QT
YF
--
-
-S
T
F
K
N
M
---
--
YFSGD
GA
RRDE
D
GY
YW
ITGR
VD
DV
L
N
VS
G
HR
L
G
TA
EIES
A
L
VA
HPKI
A
E
A
A
VVGIP
H
N
I
K
G
Q
AI
Y
AYV
T
LN
H
-
GE
E
P
S
P
E
L
Y
AE
VR
N
W
V
RK
E
I
GP
L
A
T
P
DV
L
HWT
D
S
LP
K
T
R
SGKI
MRRI
LR
fig|656437.3.peg.4583
Escherichia coli TA143 (90-616/652)
GD
R
TAII
W
E
G
DD
AS
QSKH
I
SY
K
ELH
RDVC
R
F
AN
TL
L
E
LGIKKGD
V
VA
IY
M
P
MV
PE
A
A
V
AM
LACA
R
IGAV
H
SV
I
FGGFSP
E
A
V
A
G
R
I
ID
S
NS
R
L
VI
TS
--
-
-
-
-
---
-
--
--------
D
E
GVR
AG
R
S
I
P
L
KKN
VD
D
AL
KN
P
N
VT
SV
E
HVVV
LK
R
TGGKIDWQEGRDLWWHDLV
E
Q
A
SD
Q
HQ
A
EEM
N
A
E
D
P
L
F
IL
Y
TSG
S
TG
K
PKGVL
H
T
T
G
G
Y
L
----V
Y
A
A
-
L
TFK
YV
FDYHPG
D
I
Y
WCT
A
D
V
G
W
V
TG
HSYLLY
G
P
L
AC
GAT
T
LM
F
E
GV
PNWP
TP
A
R
MAQV
VDK
H
Q
V
N
----
I
L
YTA
P
TA
IR
A
LM
A
EG
DK
A
IEGTD
R
-
S
S
LR
I
L
G
----
SVGEP
IN
P
E
AWEWY
W
KK
I
G
N
E
KCPVV
DT
WW
Q
TET
GGFM
I
T
P
L
--
-
-
PG
AT
E
LKA
G
S
A
T
R
P
F
FGV
Q
PA
LVD
N
EGN
PL
E
G
A
T
EG
S
LV
I
TD
S
WPG
Q
A
R
TLF
GDHERFE
QT
YF
--
-
-S
T
F
K
N
M
---
--
YFSGD
GA
RRDE
D
GY
YW
ITGR
VD
DV
L
N
VS
G
HR
L
G
TA
EIES
A
L
VA
HPKI
A
E
A
A
VVGIP
H
N
I
K
G
Q
AI
Y
AYV
T
LN
H
-
GE
E
P
S
P
E
L
Y
AE
VR
N
W
V
RK
E
I
GP
L
A
T
P
DV
L
HWT
D
S
LP
K
T
R
SGKI
MRRI
LR
fig|656443.3.peg.5057
Escherichia coli TA271 (90-616/652)
GD
R
TAII
W
E
G
DD
AS
QSKH
I
SY
K
ELH
RDVC
R
F
AN
TL
L
E
LGIKKGD
V
VA
IY
M
P
MV
PE
A
A
V
AM
LACA
R
IGAV
H
SV
I
FGGFSP
E
A
V
A
G
R
I
ID
S
NS
R
L
VI
TS
--
-
-
-
-
---
-
--
--------
D
E
GVR
AG
R
S
I
P
L
KKN
VD
D
AL
KN
P
N
VT
SV
E
HVVV
LK
R
TGGKIDWQEGRDLWWHDLV
E
Q
A
SD
Q
HQ
A
EEM
N
A
E
D
P
L
F
IL
Y
TSG
S
TG
K
PKGVL
H
T
T
G
G
Y
L
----V
Y
A
A
-
L
TFK
YV
FDYHPG
D
I
Y
WCT
A
D
V
G
W
V
TG
HSYLLY
G
P
L
AC
GAT
T
LM
F
E
GV
PNWP
TP
A
R
MAQV
VDK
H
Q
V
N
----
I
L
YTA
P
TA
IR
A
LM
A
EG
DK
A
IEGTD
R
-
S
S
LR
I
L
G
----
SVGEP
IN
P
E
AWEWY
W
KK
I
G
N
E
KCPVV
DT
WW
Q
TET
GGFM
I
T
P
L
--
-
-
PG
AT
E
LKA
G
S
A
T
R
P
F
FGV
Q
PA
LVD
N
EGN
PL
E
G
A
T
EG
S
LV
I
TD
S
WPG
Q
A
R
TLF
GDHERFE
QT
YF
--
-
-S
T
F
K
N
M
---
--
YFSGD
GA
RRDE
D
GY
YW
ITGR
VD
DV
L
N
VS
G
HR
L
G
TA
EIES
A
L
VA
HPKI
A
E
A
A
VVGIP
H
N
I
K
G
Q
AI
Y
AYV
T
LN
H
-
GE
E
P
S
P
E
L
Y
AE
VR
N
W
V
RK
E
I
GP
L
A
T
P
DV
L
HWT
D
S
LP
K
T
R
SGKI
MRRI
LR
fig|656444.3.peg.5530
Escherichia coli TA280 (90-616/652)
GD
R
TAII
W
E
G
DD
AS
QSKH
I
SY
K
ELH
RDVC
R
F
AN
TL
L
E
LGIKKGD
V
VA
IY
M
P
MV
PE
A
A
V
AM
LACA
R
IGAV
H
SV
I
FGGFSP
E
A
V
A
G
R
I
ID
S
NS
R
L
VI
TS
--
-
-
-
-
---
-
--
--------
D
E
GVR
AG
R
S
I
P
L
KKN
VD
D
AL
KN
P
N
VT
SV
E
HVVV
LK
R
TGGKIDWQEGRDLWWHDLV
E
Q
A
SD
Q
HQ
A
EEM
N
A
E
D
P
L
F
IL
Y
TSG
S
TG
K
PKGVL
H
T
T
G
G
Y
L
----V
Y
A
A
-
L
TFK
YV
FDYHPG
D
I
Y
WCT
A
D
V
G
W
V
TG
HSYLLY
G
P
L
AC
GAT
T
LM
F
E
GV
PNWP
TP
A
R
MAQV
VDK
H
Q
V
N
----
I
L
YTA
P
TA
IR
A
LM
A
EG
DK
A
IEGTD
R
-
S
S
LR
I
L
G
----
SVGEP
IN
P
E
AWEWY
W
KK
I
G
N
E
KCPVV
DT
WW
Q
TET
GGFM
I
T
P
L
--
-
-
PG
AT
E
LKA
G
S
A
T
R
P
F
FGV
Q
PA
LVD
N
EGN
PL
E
G
A
T
EG
S
LV
I
TD
S
WPG
Q
A
R
TLF
GDHERFE
QT
YF
--
-
-S
T
F
K
N
M
---
--
YFSGD
GA
RRDE
D
GY
YW
ITGR
VD
DV
L
N
VS
G
HR
L
G
TA
EIES
A
L
VA
HPKI
A
E
A
A
VVGIP
H
N
I
K
G
Q
AI
Y
AYV
T
LN
H
-
GE
E
P
S
P
E
L
Y
AE
VR
N
W
V
RK
E
I
GP
L
A
T
P
DV
L
HWT
D
S
LP
K
T
R
SGKI
MRRI
LR
fig|566546.3.peg.2238
Escherichia coli W (90-616/652)
GD
R
TAII
W
E
G
DD
AS
QSKH
I
SY
K
ELH
RDVC
R
F
AN
TL
L
E
LGIKKGD
V
VA
IY
M
P
MV
PE
A
A
V
AM
LACA
R
IGAV
H
SV
I
FGGFSP
E
A
V
A
G
R
I
ID
S
NS
R
L
VI
TS
--
-
-
-
-
---
-
--
--------
D
E
GVR
AG
R
S
I
P
L
KKN
VD
D
AL
KN
P
N
VT
SV
E
HVVV
LK
R
TGGKIDWQEGRDLWWHDLV
E
Q
A
SD
Q
HQ
A
EEM
N
A
E
D
P
L
F
IL
Y
TSG
S
TG
K
PKGVL
H
T
T
G
G
Y
L
----V
Y
A
A
-
L
TFK
YV
FDYHPG
D
I
Y
WCT
A
D
V
G
W
V
TG
HSYLLY
G
P
L
AC
GAT
T
LM
F
E
GV
PNWP
TP
A
R
MAQV
VDK
H
Q
V
N
----
I
L
YTA
P
TA
IR
A
LM
A
EG
DK
A
IEGTD
R
-
S
S
LR
I
L
G
----
SVGEP
IN
P
E
AWEWY
W
KK
I
G
N
E
KCPVV
DT
WW
Q
TET
GGFM
I
T
P
L
--
-
-
PG
AT
E
LKA
G
S
A
T
R
P
F
FGV
Q
PA
LVD
N
EGN
PL
E
G
A
T
EG
S
LV
I
TD
S
WPG
Q
A
R
TLF
GDHERFE
QT
YF
--
-
-S
T
F
K
N
M
---
--
YFSGD
GA
RRDE
D
GY
YW
ITGR
VD
DV
L
N
VS
G
HR
L
G
TA
EIES
A
L
VA
HPKI
A
E
A
A
VVGIP
H
N
I
K
G
Q
AI
Y
AYV
T
LN
H
-
GE
E
P
S
P
E
L
Y
AE
VR
N
W
V
RK
E
I
GP
L
A
T
P
DV
L
HWT
D
S
LP
K
T
R
SGKI
MRRI
LR
fig|566546.4.peg.4368
Escherichia coli W (90-616/652)
GD
R
TAII
W
E
G
DD
AS
QSKH
I
SY
K
ELH
RDVC
R
F
AN
TL
L
E
LGIKKGD
V
VA
IY
M
P
MV
PE
A
A
V
AM
LACA
R
IGAV
H
SV
I
FGGFSP
E
A
V
A
G
R
I
ID
S
NS
R
L
VI
TS
--
-
-
-
-
---
-
--
--------
D
E
GVR
AG
R
S
I
P
L
KKN
VD
D
AL
KN
P
N
VT
SV
E
HVVV
LK
R
TGGKIDWQEGRDLWWHDLV
E
Q
A
SD
Q
HQ
A
EEM
N
A
E
D
P
L
F
IL
Y
TSG
S
TG
K
PKGVL
H
T
T
G
G
Y
L
----V
Y
A
A
-
L
TFK
YV
FDYHPG
D
I
Y
WCT
A
D
V
G
W
V
TG
HSYLLY
G
P
L
AC
GAT
T
LM
F
E
GV
PNWP
TP
A
R
MAQV
VDK
H
Q
V
N
----
I
L
YTA
P
TA
IR
A
LM
A
EG
DK
A
IEGTD
R
-
S
S
LR
I
L
G
----
SVGEP
IN
P
E
AWEWY
W
KK
I
G
N
E
KCPVV
DT
WW
Q
TET
GGFM
I
T
P
L
--
-
-
PG
AT
E
LKA
G
S
A
T
R
P
F
FGV
Q
PA
LVD
N
EGN
PL
E
G
A
T
EG
S
LV
I
TD
S
WPG
Q
A
R
TLF
GDHERFE
QT
YF
--
-
-S
T
F
K
N
M
---
--
YFSGD
GA
RRDE
D
GY
YW
ITGR
VD
DV
L
N
VS
G
HR
L
G
TA
EIES
A
L
VA
HPKI
A
E
A
A
VVGIP
H
N
I
K
G
Q
AI
Y
AYV
T
LN
H
-
GE
E
P
S
P
E
L
Y
AE
VR
N
W
V
RK
E
I
GP
L
A
T
P
DV
L
HWT
D
S
LP
K
T
R
SGKI
MRRI
LR
fig|316407.3.peg.3906
Escherichia coli W3110 (90-616/652)
GD
R
TAII
W
E
G
DD
AS
QSKH
I
SY
K
ELH
RDVC
R
F
AN
TL
L
E
LGIKKGD
V
VA
IY
M
P
MV
PE
A
A
V
AM
LACA
R
IGAV
H
SV
I
FGGFSP
E
A
V
A
G
R
I
ID
S
NS
R
L
VI
TS
--
-
-
-
-
---
-
--
--------
D
E
GVR
AG
R
S
I
P
L
KKN
VD
D
AL
KN
P
N
VT
SV
E
HVVV
LK
R
TGGKIDWQEGRDLWWHDLV
E
Q
A
SD
Q
HQ
A
EEM
N
A
E
D
P
L
F
IL
Y
TSG
S
TG
K
PKGVL
H
T
T
G
G
Y
L
----V
Y
A
A
-
L
TFK
YV
FDYHPG
D
I
Y
WCT
A
D
V
G
W
V
TG
HSYLLY
G
P
L
AC
GAT
T
LM
F
E
GV
PNWP
TP
A
R
MAQV
VDK
H
Q
V
N
----
I
L
YTA
P
TA
IR
A
LM
A
EG
DK
A
IEGTD
R
-
S
S
LR
I
L
G
----
SVGEP
IN
P
E
AWEWY
W
KK
I
G
N
E
KCPVV
DT
WW
Q
TET
GGFM
I
T
P
L
--
-
-
PG
AT
E
LKA
G
S
A
T
R
P
F
FGV
Q
PA
LVD
N
EGN
PL
E
G
A
T
EG
S
LV
I
TD
S
WPG
Q
A
R
TLF
GDHERFE
QT
YF
--
-
-S
T
F
K
N
M
---
--
YFSGD
GA
RRDE
D
GY
YW
ITGR
VD
DV
L
N
VS
G
HR
L
G
TA
EIES
A
L
VA
HPKI
A
E
A
A
VVGIP
H
N
I
K
G
Q
AI
Y
AYV
T
LN
H
-
GE
E
P
S
P
E
L
Y
AE
VR
N
W
V
RK
E
I
GP
L
A
T
P
DV
L
HWT
D
S
LP
K
T
R
SGKI
MRRI
LR
fig|316385.5.peg.4207
Escherichia coli str. K-12 substr. DH10B (90-616/652)
GD
R
TAII
W
E
G
DD
AS
QSKH
I
SY
K
ELH
RDVC
R
F
AN
TL
L
E
LGIKKGD
V
VA
IY
M
P
MV
PE
A
A
V
AM
LACA
R
IGAV
H
SV
I
FGGFSP
E
A
V
A
G
R
I
ID
S
NS
R
L
VI
TS
--
-
-
-
-
---
-
--
--------
D
E
GVR
AG
R
S
I
P
L
KKN
VD
D
AL
KN
P
N
VT
SV
E
HVVV
LK
R
TGGKIDWQEGRDLWWHDLV
E
Q
A
SD
Q
HQ
A
EEM
N
A
E
D
P
L
F
IL
Y
TSG
S
TG
K
PKGVL
H
T
T
G
G
Y
L
----V
Y
A
A
-
L
TFK
YV
FDYHPG
D
I
Y
WCT
A
D
V
G
W
V
TG
HSYLLY
G
P
L
AC
GAT
T
LM
F
E
GV
PNWP
TP
A
R
MAQV
VDK
H
Q
V
N
----
I
L
YTA
P
TA
IR
A
LM
A
EG
DK
A
IEGTD
R
-
S
S
LR
I
L
G
----
SVGEP
IN
P
E
AWEWY
W
KK
I
G
N
E
KCPVV
DT
WW
Q
TET
GGFM
I
T
P
L
--
-
-
PG
AT
E
LKA
G
S
A
T
R
P
F
FGV
Q
PA
LVD
N
EGN
PL
E
G
A
T
EG
S
LV
I
TD
S
WPG
Q
A
R
TLF
GDHERFE
QT
YF
--
-
-S
T
F
K
N
M
---
--
YFSGD
GA
RRDE
D
GY
YW
ITGR
VD
DV
L
N
VS
G
HR
L
G
TA
EIES
A
L
VA
HPKI
A
E
A
A
VVGIP
H
N
I
K
G
Q
AI
Y
AYV
T
LN
H
-
GE
E
P
S
P
E
L
Y
AE
VR
N
W
V
RK
E
I
GP
L
A
T
P
DV
L
HWT
D
S
LP
K
T
R
SGKI
MRRI
LR
fig|316385.7.peg.4295
Escherichia coli str. K-12 substr. DH10B (90-616/652)
GD
R
TAII
W
E
G
DD
AS
QSKH
I
SY
K
ELH
RDVC
R
F
AN
TL
L
E
LGIKKGD
V
VA
IY
M
P
MV
PE
A
A
V
AM
LACA
R
IGAV
H
SV
I
FGGFSP
E
A
V
A
G
R
I
ID
S
NS
R
L
VI
TS
--
-
-
-
-
---
-
--
--------
D
E
GVR
AG
R
S
I
P
L
KKN
VD
D
AL
KN
P
N
VT
SV
E
HVVV
LK
R
TGGKIDWQEGRDLWWHDLV
E
Q
A
SD
Q
HQ
A
EEM
N
A
E
D
P
L
F
IL
Y
TSG
S
TG
K
PKGVL
H
T
T
G
G
Y
L
----V
Y
A
A
-
L
TFK
YV
FDYHPG
D
I
Y
WCT
A
D
V
G
W
V
TG
HSYLLY
G
P
L
AC
GAT
T
LM
F
E
GV
PNWP
TP
A
R
MAQV
VDK
H
Q
V
N
----
I
L
YTA
P
TA
IR
A
LM
A
EG
DK
A
IEGTD
R
-
S
S
LR
I
L
G
----
SVGEP
IN
P
E
AWEWY
W
KK
I
G
N
E
KCPVV
DT
WW
Q
TET
GGFM
I
T
P
L
--
-
-
PG
AT
E
LKA
G
S
A
T
R
P
F
FGV
Q
PA
LVD
N
EGN
PL
E
G
A
T
EG
S
LV
I
TD
S
WPG
Q
A
R
TLF
GDHERFE
QT
YF
--
-
-S
T
F
K
N
M
---
--
YFSGD
GA
RRDE
D
GY
YW
ITGR
VD
DV
L
N
VS
G
HR
L
G
TA
EIES
A
L
VA
HPKI
A
E
A
A
VVGIP
H
N
I
K
G
Q
AI
Y
AYV
T
LN
H
-
GE
E
P
S
P
E
L
Y
AE
VR
N
W
V
RK
E
I
GP
L
A
T
P
DV
L
HWT
D
S
LP
K
T
R
SGKI
MRRI
LR
fig|511145.12.peg.4192
Escherichia coli str. K-12 substr. MG1655 (90-616/652)
GD
R
TAII
W
E
G
DD
AS
QSKH
I
SY
K
ELH
RDVC
R
F
AN
TL
L
E
LGIKKGD
V
VA
IY
M
P
MV
PE
A
A
V
AM
LACA
R
IGAV
H
SV
I
FGGFSP
E
A
V
A
G
R
I
ID
S
NS
R
L
VI
TS
--
-
-
-
-
---
-
--
--------
D
E
GVR
AG
R
S
I
P
L
KKN
VD
D
AL
KN
P
N
VT
SV
E
HVVV
LK
R
TGGKIDWQEGRDLWWHDLV
E
Q
A
SD
Q
HQ
A
EEM
N
A
E
D
P
L
F
IL
Y
TSG
S
TG
K
PKGVL
H
T
T
G
G
Y
L
----V
Y
A
A
-
L
TFK
YV
FDYHPG
D
I
Y
WCT
A
D
V
G
W
V
TG
HSYLLY
G
P
L
AC
GAT
T
LM
F
E
GV
PNWP
TP
A
R
MAQV
VDK
H
Q
V
N
----
I
L
YTA
P
TA
IR
A
LM
A
EG
DK
A
IEGTD
R
-
S
S
LR
I
L
G
----
SVGEP
IN
P
E
AWEWY
W
KK
I
G
N
E
KCPVV
DT
WW
Q
TET
GGFM
I
T
P
L
--
-
-
PG
AT
E
LKA
G
S
A
T
R
P
F
FGV
Q
PA
LVD
N
EGN
PL
E
G
A
T
EG
S
LV
I
TD
S
WPG
Q
A
R
TLF
GDHERFE
QT
YF
--
-
-S
T
F
K
N
M
---
--
YFSGD
GA
RRDE
D
GY
YW
ITGR
VD
DV
L
N
VS
G
HR
L
G
TA
EIES
A
L
VA
HPKI
A
E
A
A
VVGIP
H
N
I
K
G
Q
AI
Y
AYV
T
LN
H
-
GE
E
P
S
P
E
L
Y
AE
VR
N
W
V
RK
E
I
GP
L
A
T
P
DV
L
HWT
D
S
LP
K
T
R
SGKI
MRRI
LR
fig|511145.6.peg.4174
Escherichia coli str. K-12 substr. MG1655 (90-616/652)
GD
R
TAII
W
E
G
DD
AS
QSKH
I
SY
K
ELH
RDVC
R
F
AN
TL
L
E
LGIKKGD
V
VA
IY
M
P
MV
PE
A
A
V
AM
LACA
R
IGAV
H
SV
I
FGGFSP
E
A
V
A
G
R
I
ID
S
NS
R
L
VI
TS
--
-
-
-
-
---
-
--
--------
D
E
GVR
AG
R
S
I
P
L
KKN
VD
D
AL
KN
P
N
VT
SV
E
HVVV
LK
R
TGGKIDWQEGRDLWWHDLV
E
Q
A
SD
Q
HQ
A
EEM
N
A
E
D
P
L
F
IL
Y
TSG
S
TG
K
PKGVL
H
T
T
G
G
Y
L
----V
Y
A
A
-
L
TFK
YV
FDYHPG
D
I
Y
WCT
A
D
V
G
W
V
TG
HSYLLY
G
P
L
AC
GAT
T
LM
F
E
GV
PNWP
TP
A
R
MAQV
VDK
H
Q
V
N
----
I
L
YTA
P
TA
IR
A
LM
A
EG
DK
A
IEGTD
R
-
S
S
LR
I
L
G
----
SVGEP
IN
P
E
AWEWY
W
KK
I
G
N
E
KCPVV
DT
WW
Q
TET
GGFM
I
T
P
L
--
-
-
PG
AT
E
LKA
G
S
A
T
R
P
F
FGV
Q
PA
LVD
N
EGN
PL
E
G
A
T
EG
S
LV
I
TD
S
WPG
Q
A
R
TLF
GDHERFE
QT
YF
--
-
-S
T
F
K
N
M
---
--
YFSGD
GA
RRDE
D
GY
YW
ITGR
VD
DV
L
N
VS
G
HR
L
G
TA
EIES
A
L
VA
HPKI
A
E
A
A
VVGIP
H
N
I
K
G
Q
AI
Y
AYV
T
LN
H
-
GE
E
P
S
P
E
L
Y
AE
VR
N
W
V
RK
E
I
GP
L
A
T
P
DV
L
HWT
D
S
LP
K
T
R
SGKI
MRRI
LR
fig|405955.13.peg.4562
Escherichia coli APEC O1 (90-616/652)
GD
R
TAII
W
E
G
DD
AS
QSKH
I
SY
K
ELH
RDVC
R
F
AN
TL
L
E
LGIKKGD
V
VA
IY
M
P
MV
PE
A
A
V
AM
LACA
R
IGAV
H
SV
I
FGGFSP
E
A
V
A
G
R
I
ID
S
S
S
R
L
VI
TS
--
-
-
-
-
---
-
--
--------
D
E
GVR
AG
R
S
I
P
L
KKN
VD
D
AL
KN
P
N
VT
SV
E
HVVV
LK
R
TGGKIDWQEGRDLWWHDLV
E
Q
A
SD
Q
HQ
A
EEM
N
A
E
D
P
L
F
IL
Y
TSG
S
TG
K
PKGVL
H
T
T
G
G
Y
L
----V
Y
A
A
-
L
TFK
YV
FDYHPG
D
I
Y
WCT
A
D
V
G
W
V
TG
HSYLLY
G
P
L
AC
GAT
T
LM
F
E
GV
PNWP
TP
A
R
MAQV
VDK
H
Q
V
N
----
I
L
YTA
P
TA
IR
A
LM
A
EG
DK
A
IEGTD
R
-
S
S
LR
I
L
G
----
SVGEP
IN
P
E
AWEWY
W
KK
I
G
N
E
KCPVV
DT
WW
Q
TET
GGFM
I
T
P
L
--
-
-
PG
AT
E
LKA
G
S
A
T
R
P
F
FGV
Q
PA
LVD
N
EGN
PL
E
G
A
T
EG
S
LV
I
TD
S
WPG
Q
A
R
TLF
GDHERFE
QT
YF
--
-
-S
T
F
K
N
M
---
--
YFSGD
GA
RRDE
D
GY
YW
ITGR
VD
DV
L
N
VS
G
HR
L
G
TA
EIES
A
L
VA
HPKI
A
E
A
A
VVGIP
H
N
I
K
G
Q
AI
Y
AYV
T
LN
H
-
GE
E
P
S
P
E
L
Y
AE
VR
N
W
V
RK
E
I
GP
L
A
T
P
DV
L
HWT
D
S
LP
K
T
R
SGKI
MRRI
LR
fig|405955.9.peg.3851
Escherichia coli APEC O1 (90-616/652)
GD
R
TAII
W
E
G
DD
AS
QSKH
I
SY
K
ELH
RDVC
R
F
AN
TL
L
E
LGIKKGD
V
VA
IY
M
P
MV
PE
A
A
V
AM
LACA
R
IGAV
H
SV
I
FGGFSP
E
A
V
A
G
R
I
ID
S
S
S
R
L
VI
TS
--
-
-
-
-
---
-
--
--------
D
E
GVR
AG
R
S
I
P
L
KKN
VD
D
AL
KN
P
N
VT
SV
E
HVVV
LK
R
TGGKIDWQEGRDLWWHDLV
E
Q
A
SD
Q
HQ
A
EEM
N
A
E
D
P
L
F
IL
Y
TSG
S
TG
K
PKGVL
H
T
T
G
G
Y
L
----V
Y
A
A
-
L
TFK
YV
FDYHPG
D
I
Y
WCT
A
D
V
G
W
V
TG
HSYLLY
G
P
L
AC
GAT
T
LM
F
E
GV
PNWP
TP
A
R
MAQV
VDK
H
Q
V
N
----
I
L
YTA
P
TA
IR
A
LM
A
EG
DK
A
IEGTD
R
-
S
S
LR
I
L
G
----
SVGEP
IN
P
E
AWEWY
W
KK
I
G
N
E
KCPVV
DT
WW
Q
TET
GGFM
I
T
P
L
--
-
-
PG
AT
E
LKA
G
S
A
T
R
P
F
FGV
Q
PA
LVD
N
EGN
PL
E
G
A
T
EG
S
LV
I
TD
S
WPG
Q
A
R
TLF
GDHERFE
QT
YF
--
-
-S
T
F
K
N
M
---
--
YFSGD
GA
RRDE
D
GY
YW
ITGR
VD
DV
L
N
VS
G
HR
L
G
TA
EIES
A
L
VA
HPKI
A
E
A
A
VVGIP
H
N
I
K
G
Q
AI
Y
AYV
T
LN
H
-
GE
E
P
S
P
E
L
Y
AE
VR
N
W
V
RK
E
I
GP
L
A
T
P
DV
L
HWT
D
S
LP
K
T
R
SGKI
MRRI
LR
fig|714962.3.peg.4600
Escherichia coli IHE3034 (90-616/652)
GD
R
TAII
W
E
G
DD
AS
QSKH
I
SY
K
ELH
RDVC
R
F
AN
TL
L
E
LGIKKGD
V
VA
IY
M
P
MV
PE
A
A
V
AM
LACA
R
IGAV
H
SV
I
FGGFSP
E
A
V
A
G
R
I
ID
S
S
S
R
L
VI
TS
--
-
-
-
-
---
-
--
--------
D
E
GVR
AG
R
S
I
P
L
KKN
VD
D
AL
KN
P
N
VT
SV
E
HVVV
LK
R
TGGKIDWQEGRDLWWHDLV
E
Q
A
SD
Q
HQ
A
EEM
N
A
E
D
P
L
F
IL
Y
TSG
S
TG
K
PKGVL
H
T
T
G
G
Y
L
----V
Y
A
A
-
L
TFK
YV
FDYHPG
D
I
Y
WCT
A
D
V
G
W
V
TG
HSYLLY
G
P
L
AC
GAT
T
LM
F
E
GV
PNWP
TP
A
R
MAQV
VDK
H
Q
V
N
----
I
L
YTA
P
TA
IR
A
LM
A
EG
DK
A
IEGTD
R
-
S
S
LR
I
L
G
----
SVGEP
IN
P
E
AWEWY
W
KK
I
G
N
E
KCPVV
DT
WW
Q
TET
GGFM
I
T
P
L
--
-
-
PG
AT
E
LKA
G
S
A
T
R
P
F
FGV
Q
PA
LVD
N
EGN
PL
E
G
A
T
EG
S
LV
I
TD
S
WPG
Q
A
R
TLF
GDHERFE
QT
YF
--
-
-S
T
F
K
N
M
---
--
YFSGD
GA
RRDE
D
GY
YW
ITGR
VD
DV
L
N
VS
G
HR
L
G
TA
EIES
A
L
VA
HPKI
A
E
A
A
VVGIP
H
N
I
K
G
Q
AI
Y
AYV
T
LN
H
-
GE
E
P
S
P
E
L
Y
AE
VR
N
W
V
RK
E
I
GP
L
A
T
P
DV
L
HWT
D
S
LP
K
T
R
SGKI
MRRI
LR
fig|585035.6.peg.4461
Escherichia coli S88 (90-616/652)
GD
R
TAII
W
E
G
DD
AS
QSKH
I
SY
K
ELH
RDVC
R
F
AN
TL
L
E
LGIKKGD
V
VA
IY
M
P
MV
PE
A
A
V
AM
LACA
R
IGAV
H
SV
I
FGGFSP
E
A
V
A
G
R
I
ID
S
S
S
R
L
VI
TS
--
-
-
-
-
---
-
--
--------
D
E
GVR
AG
R
S
I
P
L
KKN
VD
D
AL
KN
P
N
VT
SV
E
HVVV
LK
R
TGGKIDWQEGRDLWWHDLV
E
Q
A
SD
Q
HQ
A
EEM
N
A
E
D
P
L
F
IL
Y
TSG
S
TG
K
PKGVL
H
T
T
G
G
Y
L
----V
Y
A
A
-
L
TFK
YV
FDYHPG
D
I
Y
WCT
A
D
V
G
W
V
TG
HSYLLY
G
P
L
AC
GAT
T
LM
F
E
GV
PNWP
TP
A
R
MAQV
VDK
H
Q
V
N
----
I
L
YTA
P
TA
IR
A
LM
A
EG
DK
A
IEGTD
R
-
S
S
LR
I
L
G
----
SVGEP
IN
P
E
AWEWY
W
KK
I
G
N
E
KCPVV
DT
WW
Q
TET
GGFM
I
T
P
L
--
-
-
PG
AT
E
LKA
G
S
A
T
R
P
F
FGV
Q
PA
LVD
N
EGN
PL
E
G
A
T
EG
S
LV
I
TD
S
WPG
Q
A
R
TLF
GDHERFE
QT
YF
--
-
-S
T
F
K
N
M
---
--
YFSGD
GA
RRDE
D
GY
YW
ITGR
VD
DV
L
N
VS
G
HR
L
G
TA
EIES
A
L
VA
HPKI
A
E
A
A
VVGIP
H
N
I
K
G
Q
AI
Y
AYV
T
LN
H
-
GE
E
P
S
P
E
L
Y
AE
VR
N
W
V
RK
E
I
GP
L
A
T
P
DV
L
HWT
D
S
LP
K
T
R
SGKI
MRRI
LR
fig|869729.3.peg.4412
Escherichia coli UM146 (90-616/652)
GD
R
TAII
W
E
G
DD
AS
QSKH
I
SY
K
ELH
RDVC
R
F
AN
TL
L
E
LGIKKGD
V
VA
IY
M
P
MV
PE
A
A
V
AM
LACA
R
IGAV
H
SV
I
FGGFSP
E
A
V
A
G
R
I
ID
S
S
S
R
L
VI
TS
--
-
-
-
-
---
-
--
--------
D
E
GVR
AG
R
S
I
P
L
KKN
VD
D
AL
KN
P
N
VT
SV
E
HVVV
LK
R
TGGKIDWQEGRDLWWHDLV
E
Q
A
SD
Q
HQ
A
EEM
N
A
E
D
P
L
F
IL
Y
TSG
S
TG
K
PKGVL
H
T
T
G
G
Y
L
----V
Y
A
A
-
L
TFK
YV
FDYHPG
D
I
Y
WCT
A
D
V
G
W
V
TG
HSYLLY
G
P
L
AC
GAT
T
LM
F
E
GV
PNWP
TP
A
R
MAQV
VDK
H
Q
V
N
----
I
L
YTA
P
TA
IR
A
LM
A
EG
DK
A
IEGTD
R
-
S
S
LR
I
L
G
----
SVGEP
IN
P
E
AWEWY
W
KK
I
G
N
E
KCPVV
DT
WW
Q
TET
GGFM
I
T
P
L
--
-
-
PG
AT
E
LKA
G
S
A
T
R
P
F
FGV
Q
PA
LVD
N
EGN
PL
E
G
A
T
EG
S
LV
I
TD
S
WPG
Q
A
R
TLF
GDHERFE
QT
YF
--
-
-S
T
F
K
N
M
---
--
YFSGD
GA
RRDE
D
GY
YW
ITGR
VD
DV
L
N
VS
G
HR
L
G
TA
EIES
A
L
VA
HPKI
A
E
A
A
VVGIP
H
N
I
K
G
Q
AI
Y
AYV
T
LN
H
-
GE
E
P
S
P
E
L
Y
AE
VR
N
W
V
RK
E
I
GP
L
A
T
P
DV
L
HWT
D
S
LP
K
T
R
SGKI
MRRI
LR
fig|364106.7.peg.4536
Escherichia coli UTI89 (90-616/652)
GD
R
TAII
W
E
G
DD
AS
QSKH
I
SY
K
ELH
RDVC
R
F
AN
TL
L
E
LGIKKGD
V
VA
IY
M
P
MV
PE
A
A
V
AM
LACA
R
IGAV
H
SV
I
FGGFSP
E
A
V
A
G
R
I
ID
S
S
S
R
L
VI
TS
--
-
-
-
-
---
-
--
--------
D
E
GVR
AG
R
S
I
P
L
KKN
VD
D
AL
KN
P
N
VT
SV
E
HVVV
LK
R
TGGKIDWQEGRDLWWHDLV
E
Q
A
SD
Q
HQ
A
EEM
N
A
E
D
P
L
F
IL
Y
TSG
S
TG
K
PKGVL
H
T
T
G
G
Y
L
----V
Y
A
A
-
L
TFK
YV
FDYHPG
D
I
Y
WCT
A
D
V
G
W
V
TG
HSYLLY
G
P
L
AC
GAT
T
LM
F
E
GV
PNWP
TP
A
R
MAQV
VDK
H
Q
V
N
----
I
L
YTA
P
TA
IR
A
LM
A
EG
DK
A
IEGTD
R
-
S
S
LR
I
L
G
----
SVGEP
IN
P
E
AWEWY
W
KK
I
G
N
E
KCPVV
DT
WW
Q
TET
GGFM
I
T
P
L
--
-
-
PG
AT
E
LKA
G
S
A
T
R
P
F
FGV
Q
PA
LVD
N
EGN
PL
E
G
A
T
EG
S
LV
I
TD
S
WPG
Q
A
R
TLF
GDHERFE
QT
YF
--
-
-S
T
F
K
N
M
---
--
YFSGD
GA
RRDE
D
GY
YW
ITGR
VD
DV
L
N
VS
G
HR
L
G
TA
EIES
A
L
VA
HPKI
A
E
A
A
VVGIP
H
N
I
K
G
Q
AI
Y
AYV
T
LN
H
-
GE
E
P
S
P
E
L
Y
AE
VR
N
W
V
RK
E
I
GP
L
A
T
P
DV
L
HWT
D
S
LP
K
T
R
SGKI
MRRI
LR
fig|364106.8.peg.4535
Escherichia coli UTI89 (90-616/652)
GD
R
TAII
W
E
G
DD
AS
QSKH
I
SY
K
ELH
RDVC
R
F
AN
TL
L
E
LGIKKGD
V
VA
IY
M
P
MV
PE
A
A
V
AM
LACA
R
IGAV
H
SV
I
FGGFSP
E
A
V
A
G
R
I
ID
S
S
S
R
L
VI
TS
--
-
-
-
-
---
-
--
--------
D
E
GVR
AG
R
S
I
P
L
KKN
VD
D
AL
KN
P
N
VT
SV
E
HVVV
LK
R
TGGKIDWQEGRDLWWHDLV
E
Q
A
SD
Q
HQ
A
EEM
N
A
E
D
P
L
F
IL
Y
TSG
S
TG
K
PKGVL
H
T
T
G
G
Y
L
----V
Y
A
A
-
L
TFK
YV
FDYHPG
D
I
Y
WCT
A
D
V
G
W
V
TG
HSYLLY
G
P
L
AC
GAT
T
LM
F
E
GV
PNWP
TP
A
R
MAQV
VDK
H
Q
V
N
----
I
L
YTA
P
TA
IR
A
LM
A
EG
DK
A
IEGTD
R
-
S
S
LR
I
L
G
----
SVGEP
IN
P
E
AWEWY
W
KK
I
G
N
E
KCPVV
DT
WW
Q
TET
GGFM
I
T
P
L
--
-
-
PG
AT
E
LKA
G
S
A
T
R
P
F
FGV
Q
PA
LVD
N
EGN
PL
E
G
A
T
EG
S
LV
I
TD
S
WPG
Q
A
R
TLF
GDHERFE
QT
YF
--
-
-S
T
F
K
N
M
---
--
YFSGD
GA
RRDE
D
GY
YW
ITGR
VD
DV
L
N
VS
G
HR
L
G
TA
EIES
A
L
VA
HPKI
A
E
A
A
VVGIP
H
N
I
K
G
Q
AI
Y
AYV
T
LN
H
-
GE
E
P
S
P
E
L
Y
AE
VR
N
W
V
RK
E
I
GP
L
A
T
P
DV
L
HWT
D
S
LP
K
T
R
SGKI
MRRI
LR
fig|585057.4.peg.4630
Escherichia coli IAI39 (90-616/652)
GD
R
TAII
W
E
G
DD
AS
QSKH
I
SY
K
ELH
RDVC
R
F
AN
TL
L
E
LGIKKGD
V
VA
IY
M
P
MV
PE
A
A
V
AM
LACA
R
IGAV
H
SV
I
FGGFSP
E
A
V
A
G
R
I
ID
S
NS
R
L
VI
TS
--
-
-
-
-
---
-
--
--------
D
E
GVR
AG
R
S
I
P
L
KKN
VD
D
AL
KN
P
N
VT
SV
E
HVVV
LK
R
TGGKIDWQEGRDLWWHDL
I
E
Q
A
SD
Q
HQ
A
QEM
N
A
E
D
P
L
F
IL
Y
TSG
S
TG
K
PKGVL
H
T
T
G
G
Y
L
----V
Y
A
A
-
L
TFK
YV
FDYHPG
D
I
Y
WCT
A
D
V
G
W
V
TG
HSYLLY
G
P
L
AC
GAT
T
LM
F
E
GV
PNWP
TP
A
R
MAQV
VDK
H
Q
V
N
----
I
L
YTA
P
TA
IR
A
LM
A
EG
DK
A
IEGTD
R
-
S
S
LR
I
L
G
----
SVGEP
IN
P
E
AWEWY
W
KK
I
G
N
E
KCPVV
DT
WW
Q
TET
GGFM
I
T
P
L
--
-
-
PG
AT
E
LKA
G
S
A
T
R
P
F
FGV
Q
PA
LVD
N
EGN
PL
E
G
A
T
EG
S
LV
I
TD
S
WPG
Q
A
R
TLF
GDHERFE
QT
YF
--
-
-S
T
F
K
N
M
---
--
YFSGD
GA
RRDE
D
GY
YW
ITGR
VD
DV
L
N
VS
G
HR
L
G
TA
EIES
A
L
VA
HPKI
A
E
A
A
VVGIP
H
N
I
K
G
Q
AI
Y
AYV
T
LN
H
-
GE
E
P
S
P
E
L
Y
AE
VR
N
W
V
RK
E
I
GP
L
A
T
P
DV
L
HWT
D
S
LP
K
T
R
SGKI
MRRI
LR
fig|585057.6.peg.4639
Escherichia coli IAI39 (90-616/652)
GD
R
TAII
W
E
G
DD
AS
QSKH
I
SY
K
ELH
RDVC
R
F
AN
TL
L
E
LGIKKGD
V
VA
IY
M
P
MV
PE
A
A
V
AM
LACA
R
IGAV
H
SV
I
FGGFSP
E
A
V
A
G
R
I
ID
S
NS
R
L
VI
TS
--
-
-
-
-
---
-
--
--------
D
E
GVR
AG
R
S
I
P
L
KKN
VD
D
AL
KN
P
N
VT
SV
E
HVVV
LK
R
TGGKIDWQEGRDLWWHDL
I
E
Q
A
SD
Q
HQ
A
QEM
N
A
E
D
P
L
F
IL
Y
TSG
S
TG
K
PKGVL
H
T
T
G
G
Y
L
----V
Y
A
A
-
L
TFK
YV
FDYHPG
D
I
Y
WCT
A
D
V
G
W
V
TG
HSYLLY
G
P
L
AC
GAT
T
LM
F
E
GV
PNWP
TP
A
R
MAQV
VDK
H
Q
V
N
----
I
L
YTA
P
TA
IR
A
LM
A
EG
DK
A
IEGTD
R
-
S
S
LR
I
L
G
----
SVGEP
IN
P
E
AWEWY
W
KK
I
G
N
E
KCPVV
DT
WW
Q
TET
GGFM
I
T
P
L
--
-
-
PG
AT
E
LKA
G
S
A
T
R
P
F
FGV
Q
PA
LVD
N
EGN
PL
E
G
A
T
EG
S
LV
I
TD
S
WPG
Q
A
R
TLF
GDHERFE
QT
YF
--
-
-S
T
F
K
N
M
---
--
YFSGD
GA
RRDE
D
GY
YW
ITGR
VD
DV
L
N
VS
G
HR
L
G
TA
EIES
A
L
VA
HPKI
A
E
A
A
VVGIP
H
N
I
K
G
Q
AI
Y
AYV
T
LN
H
-
GE
E
P
S
P
E
L
Y
AE
VR
N
W
V
RK
E
I
GP
L
A
T
P
DV
L
HWT
D
S
LP
K
T
R
SGKI
MRRI
LR
fig|562.371.peg.3580
Escherichia coli 1044A (90-616/652)
GD
R
TAII
W
E
G
DD
AS
QSKH
I
SY
K
ELH
RDVC
R
F
AN
TL
L
K
LGIKKGD
V
VA
IY
M
P
MV
PE
A
A
V
AM
LACA
R
IGAV
H
SV
I
FGGFSP
E
A
V
A
G
R
I
ID
S
NS
R
L
VI
TS
--
-
-
-
-
---
-
--
--------
D
E
GVR
AG
R
S
I
P
L
KKN
VD
D
AL
KN
P
N
VT
SV
E
HVVV
LK
R
TGGKIDWQEGRDLWWHD
Q
V
E
Q
A
SD
Q
HQ
A
EEM
N
A
E
D
P
L
F
IL
Y
TSG
S
TG
K
PKGVL
H
T
T
G
G
Y
L
----V
Y
A
A
-
L
TFK
YV
FDYHPG
D
I
Y
WCT
A
D
V
G
W
V
TG
HSYLLY
G
P
L
AC
GAT
T
LM
F
E
GV
PNWP
TP
A
R
MAQV
VDK
H
Q
V
N
----
I
L
YTA
P
TA
IR
A
LM
A
EG
DK
A
IEGTD
R
-
S
S
LR
I
L
G
----
SVGEP
IN
P
E
AWEWY
W
KK
I
G
N
E
KCPVV
DT
WW
Q
TET
GGFM
I
T
P
L
--
-
-
PG
AT
E
LKA
G
S
A
T
R
P
F
FGV
Q
PA
LVD
N
EGN
PL
E
G
A
T
EG
S
LV
I
TD
S
WPG
Q
A
R
TLF
GDHERFE
QT
YF
--
-
-S
T
F
K
N
M
---
--
YFSGD
GA
RRDE
D
S
Y
YW
ITGR
VD
DV
L
N
VS
G
HR
L
G
TA
EIES
A
L
VA
HPKI
A
E
A
A
VVGIP
H
N
I
K
G
Q
AI
Y
AYV
T
LN
H
-
GE
E
P
S
P
E
L
Y
AE
VR
N
W
V
RK
E
I
GP
L
A
T
P
DV
L
HWT
D
S
LP
K
T
R
SGKI
MRRI
LR
fig|562.373.peg.5824
Escherichia coli 1125A (90-616/652)
GD
R
TAII
W
E
G
DD
AS
QSKH
I
SY
K
ELH
RDVC
R
F
AN
TL
L
K
LGIKKGD
V
VA
IY
M
P
MV
PE
A
A
V
AM
LACA
R
IGAV
H
SV
I
FGGFSP
E
A
V
A
G
R
I
ID
S
NS
R
L
VI
TS
--
-
-
-
-
---
-
--
--------
D
E
GVR
AG
R
S
I
P
L
KKN
VD
D
AL
KN
P
N
VT
SV
E
HVVV
LK
R
TGGKIDWQEGRDLWWHD
Q
V
E
Q
A
SD
Q
HQ
A
EEM
N
A
E
D
P
L
F
IL
Y
TSG
S
TG
K
PKGVL
H
T
T
G
G
Y
L
----V
Y
A
A
-
L
TFK
YV
FDYHPG
D
I
Y
WCT
A
D
V
G
W
V
TG
HSYLLY
G
P
L
AC
GAT
T
LM
F
E
GV
PNWP
TP
A
R
MAQV
VDK
H
Q
V
N
----
I
L
YTA
P
TA
IR
A
LM
A
EG
DK
A
IEGTD
R
-
S
S
LR
I
L
G
----
SVGEP
IN
P
E
AWEWY
W
KK
I
G
N
E
KCPVV
DT
WW
Q
TET
GGFM
I
T
P
L
--
-
-
PG
AT
E
LKA
G
S
A
T
R
P
F
FGV
Q
PA
LVD
N
EGN
PL
E
G
A
T
EG
S
LV
I
TD
S
WPG
Q
A
R
TLF
GDHERFE
QT
YF
--
-
-S
T
F
K
N
M
---
--
YFSGD
GA
RRDE
D
S
Y
YW
ITGR
VD
DV
L
N
VS
G
HR
L
G
TA
EIES
A
L
VA
HPKI
A
E
A
A
VVGIP
H
N
I
K
G
Q
AI
Y
AYV
T
LN
H
-
GE
E
P
S
P
E
L
Y
AE
VR
N
W
V
RK
E
I
GP
L
A
T
P
DV
L
HWT
D
S
LP
K
T
R
SGKI
MRRI
LR
fig|562.372.peg.3478
Escherichia coli 1212A (90-616/652)
GD
R
TAII
W
E
G
DD
AS
QSKH
I
SY
K
ELH
RDVC
R
F
AN
TL
L
K
LGIKKGD
V
VA
IY
M
P
MV
PE
A
A
V
AM
LACA
R
IGAV
H
SV
I
FGGFSP
E
A
V
A
G
R
I
ID
S
NS
R
L
VI
TS
--
-
-
-
-
---
-
--
--------
D
E
GVR
AG
R
S
I
P
L
KKN
VD
D
AL
KN
P
N
VT
SV
E
HVVV
LK
R
TGGKIDWQEGRDLWWHD
Q
V
E
Q
A
SD
Q
HQ
A
EEM
N
A
E
D
P
L
F
IL
Y
TSG
S
TG
K
PKGVL
H
T
T
G
G
Y
L
----V
Y
A
A
-
L
TFK
YV
FDYHPG
D
I
Y
WCT
A
D
V
G
W
V
TG
HSYLLY
G
P
L
AC
GAT
T
LM
F
E
GV
PNWP
TP
A
R
MAQV
VDK
H
Q
V
N
----
I
L
YTA
P
TA
IR
A
LM
A
EG
DK
A
IEGTD
R
-
S
S
LR
I
L
G
----
SVGEP
IN
P
E
AWEWY
W
KK
I
G
N
E
KCPVV
DT
WW
Q
TET
GGFM
I
T
P
L
--
-
-
PG
AT
E
LKA
G
S
A
T
R
P
F
FGV
Q
PA
LVD
N
EGN
PL
E
G
A
T
EG
S
LV
I
TD
S
WPG
Q
A
R
TLF
GDHERFE
QT
YF
--
-
-S
T
F
K
N
M
---
--
YFSGD
GA
RRDE
D
S
Y
YW
ITGR
VD
DV
L
N
VS
G
HR
L
G
TA
EIES
A
L
VA
HPKI
A
E
A
A
VVGIP
H
N
I
K
G
Q
AI
Y
AYV
T
LN
H
-
GE
E
P
S
P
E
L
Y
AE
VR
N
W
V
RK
E
I
GP
L
A
T
P
DV
L
HWT
D
S
LP
K
T
R
SGKI
MRRI
LR
fig|562.374.peg.2813
Escherichia coli 536A (90-616/652)
GD
R
TAII
W
E
G
DD
AS
QSKH
I
SY
K
ELH
RDVC
R
F
AN
TL
L
K
LGIKKGD
V
VA
IY
M
P
MV
PE
A
A
V
AM
LACA
R
IGAV
H
SV
I
FGGFSP
E
A
V
A
G
R
I
ID
S
NS
R
L
VI
TS
--
-
-
-
-
---
-
--
--------
D
E
GVR
AG
R
S
I
P
L
KKN
VD
D
AL
KN
P
N
VT
SV
E
HVVV
LK
R
TGGKIDWQEGRDLWWHD
Q
V
E
Q
A
SD
Q
HQ
A
EEM
N
A
E
D
P
L
F
IL
Y
TSG
S
TG
K
PKGVL
H
T
T
G
G
Y
L
----V
Y
A
A
-
L
TFK
YV
FDYHPG
D
I
Y
WCT
A
D
V
G
W
V
TG
HSYLLY
G
P
L
AC
GAT
T
LM
F
E
GV
PNWP
TP
A
R
MAQV
VDK
H
Q
V
N
----
I
L
YTA
P
TA
IR
A
LM
A
EG
DK
A
IEGTD
R
-
S
S
LR
I
L
G
----
SVGEP
IN
P
E
AWEWY
W
KK
I
G
N
E
KCPVV
DT
WW
Q
TET
GGFM
I
T
P
L
--
-
-
PG
AT
E
LKA
G
S
A
T
R
P
F
FGV
Q
PA
LVD
N
EGN
PL
E
G
A
T
EG
S
LV
I
TD
S
WPG
Q
A
R
TLF
GDHERFE
QT
YF
--
-
-S
T
F
K
N
M
---
--
YFSGD
GA
RRDE
D
S
Y
YW
ITGR
VD
DV
L
N
VS
G
HR
L
G
TA
EIES
A
L
VA
HPKI
A
E
A
A
VVGIP
H
N
I
K
G
Q
AI
Y
AYV
T
LN
H
-
GE
E
P
S
P
E
L
Y
AE
VR
N
W
V
RK
E
I
GP
L
A
T
P
DV
L
HWT
D
S
LP
K
T
R
SGKI
MRRI
LR
fig|83334.1.peg.5028
Escherichia coli O157:H7 (90-616/652)
GD
R
TAII
W
E
G
DD
AS
QSKH
I
SY
K
ELH
RDVC
R
F
AN
TL
L
K
LGIKKGD
V
VA
IY
M
P
MV
PE
A
A
V
AM
LACA
R
IGAV
H
SV
I
FGGFSP
E
A
V
A
G
R
I
ID
S
NS
R
L
VI
TS
--
-
-
-
-
---
-
--
--------
D
E
GVR
AG
R
S
I
P
L
KKN
VD
D
AL
KN
P
N
VT
SV
E
HVVV
LK
R
TGGKIDWQEGRDLWWHD
Q
V
E
Q
A
SD
Q
HQ
A
EEM
N
A
E
D
P
L
F
IL
Y
TSG
S
TG
K
PKGVL
H
T
T
G
G
Y
L
----V
Y
A
A
-
L
TFK
YV
FDYHPG
D
I
Y
WCT
A
D
V
G
W
V
TG
HSYLLY
G
P
L
AC
GAT
T
LM
F
E
GV
PNWP
TP
A
R
MAQV
VDK
H
Q
V
N
----
I
L
YTA
P
TA
IR
A
LM
A
EG
DK
A
IEGTD
R
-
S
S
LR
I
L
G
----
SVGEP
IN
P
E
AWEWY
W
KK
I
G
N
E
KCPVV
DT
WW
Q
TET
GGFM
I
T
P
L
--
-
-
PG
AT
E
LKA
G
S
A
T
R
P
F
FGV
Q
PA
LVD
N
EGN
PL
E
G
A
T
EG
S
LV
I
TD
S
WPG
Q
A
R
TLF
GDHERFE
QT
YF
--
-
-S
T
F
K
N
M
---
--
YFSGD
GA
RRDE
D
S
Y
YW
ITGR
VD
DV
L
N
VS
G
HR
L
G
TA
EIES
A
L
VA
HPKI
A
E
A
A
VVGIP
H
N
I
K
G
Q
AI
Y
AYV
T
LN
H
-
GE
E
P
S
P
E
L
Y
AE
VR
N
W
V
RK
E
I
GP
L
A
T
P
DV
L
HWT
D
S
LP
K
T
R
SGKI
MRRI
LR
fig|155864.1.peg.5010
Escherichia coli O157:H7 EDL933 (90-616/652)
GD
R
TAII
W
E
G
DD
AS
QSKH
I
SY
K
ELH
RDVC
R
F
AN
TL
L
K
LGIKKGD
V
VA
IY
M
P
MV
PE
A
A
V
AM
LACA
R
IGAV
H
SV
I
FGGFSP
E
A
V
A
G
R
I
ID
S
NS
R
L
VI
TS
--
-
-
-
-
---
-
--
--------
D
E
GVR
AG
R
S
I
P
L
KKN
VD
D
AL
KN
P
N
VT
SV
E
HVVV
LK
R
TGGKIDWQEGRDLWWHD
Q
V
E
Q
A
SD
Q
HQ
A
EEM
N
A
E
D
P
L
F
IL
Y
TSG
S
TG
K
PKGVL
H
T
T
G
G
Y
L
----V
Y
A
A
-
L
TFK
YV
FDYHPG
D
I
Y
WCT
A
D
V
G
W
V
TG
HSYLLY
G
P
L
AC
GAT
T
LM
F
E
GV
PNWP
TP
A
R
MAQV
VDK
H
Q
V
N
----
I
L
YTA
P
TA
IR
A
LM
A
EG
DK
A
IEGTD
R
-
S
S
LR
I
L
G
----
SVGEP
IN
P
E
AWEWY
W
KK
I
G
N
E
KCPVV
DT
WW
Q
TET
GGFM
I
T
P
L
--
-
-
PG
AT
E
LKA
G
S
A
T
R
P
F
FGV
Q
PA
LVD
N
EGN
PL
E
G
A
T
EG
S
LV
I
TD
S
WPG
Q
A
R
TLF
GDHERFE
QT
YF
--
-
-S
T
F
K
N
M
---
--
YFSGD
GA
RRDE
D
S
Y
YW
ITGR
VD
DV
L
N
VS
G
HR
L
G
TA
EIES
A
L
VA
HPKI
A
E
A
A
VVGIP
H
N
I
K
G
Q
AI
Y
AYV
T
LN
H
-
GE
E
P
S
P
E
L
Y
AE
VR
N
W
V
RK
E
I
GP
L
A
T
P
DV
L
HWT
D
S
LP
K
T
R
SGKI
MRRI
LR
fig|155864.8.peg.4988
Escherichia coli O157:H7 EDL933 (90-616/652)
GD
R
TAII
W
E
G
DD
AS
QSKH
I
SY
K
ELH
RDVC
R
F
AN
TL
L
K
LGIKKGD
V
VA
IY
M
P
MV
PE
A
A
V
AM
LACA
R
IGAV
H
SV
I
FGGFSP
E
A
V
A
G
R
I
ID
S
NS
R
L
VI
TS
--
-
-
-
-
---
-
--
--------
D
E
GVR
AG
R
S
I
P
L
KKN
VD
D
AL
KN
P
N
VT
SV
E
HVVV
LK
R
TGGKIDWQEGRDLWWHD
Q
V
E
Q
A
SD
Q
HQ
A
EEM
N
A
E
D
P
L
F
IL
Y
TSG
S
TG
K
PKGVL
H
T
T
G
G
Y
L
----V
Y
A
A
-
L
TFK
YV
FDYHPG
D
I
Y
WCT
A
D
V
G
W
V
TG
HSYLLY
G
P
L
AC
GAT
T
LM
F
E
GV
PNWP
TP
A
R
MAQV
VDK
H
Q
V
N
----
I
L
YTA
P
TA
IR
A
LM
A
EG
DK
A
IEGTD
R
-
S
S
LR
I
L
G
----
SVGEP
IN
P
E
AWEWY
W
KK
I
G
N
E
KCPVV
DT
WW
Q
TET
GGFM
I
T
P
L
--
-
-
PG
AT
E
LKA
G
S
A
T
R
P
F
FGV
Q
PA
LVD
N
EGN
PL
E
G
A
T
EG
S
LV
I
TD
S
WPG
Q
A
R
TLF
GDHERFE
QT
YF
--
-
-S
T
F
K
N
M
---
--
YFSGD
GA
RRDE
D
S
Y
YW
ITGR
VD
DV
L
N
VS
G
HR
L
G
TA
EIES
A
L
VA
HPKI
A
E
A
A
VVGIP
H
N
I
K
G
Q
AI
Y
AYV
T
LN
H
-
GE
E
P
S
P
E
L
Y
AE
VR
N
W
V
RK
E
I
GP
L
A
T
P
DV
L
HWT
D
S
LP
K
T
R
SGKI
MRRI
LR
fig|444454.5.peg.4129
Escherichia coli O157:H7 str. EC4024 (90-616/652)
GD
R
TAII
W
E
G
DD
AS
QSKH
I
SY
K
ELH
RDVC
R
F
AN
TL
L
K
LGIKKGD
V
VA
IY
M
P
MV
PE
A
A
V
AM
LACA
R
IGAV
H
SV
I
FGGFSP
E
A
V
A
G
R
I
ID
S
NS
R
L
VI
TS
--
-
-
-
-
---
-
--
--------
D
E
GVR
AG
R
S
I
P
L
KKN
VD
D
AL
KN
P
N
VT
SV
E
HVVV
LK
R
TGGKIDWQEGRDLWWHD
Q
V
E
Q
A
SD
Q
HQ
A
EEM
N
A
E
D
P
L
F
IL
Y
TSG
S
TG
K
PKGVL
H
T
T
G
G
Y
L
----V
Y
A
A
-
L
TFK
YV
FDYHPG
D
I
Y
WCT
A
D
V
G
W
V
TG
HSYLLY
G
P
L
AC
GAT
T
LM
F
E
GV
PNWP
TP
A
R
MAQV
VDK
H
Q
V
N
----
I
L
YTA
P
TA
IR
A
LM
A
EG
DK
A
IEGTD
R
-
S
S
LR
I
L
G
----
SVGEP
IN
P
E
AWEWY
W
KK
I
G
N
E
KCPVV
DT
WW
Q
TET
GGFM
I
T
P
L
--
-
-
PG
AT
E
LKA
G
S
A
T
R
P
F
FGV
Q
PA
LVD
N
EGN
PL
E
G
A
T
EG
S
LV
I
TD
S
WPG
Q
A
R
TLF
GDHERFE
QT
YF
--
-
-S
T
F
K
N
M
---
--
YFSGD
GA
RRDE
D
S
Y
YW
ITGR
VD
DV
L
N
VS
G
HR
L
G
TA
EIES
A
L
VA
HPKI
A
E
A
A
VVGIP
H
N
I
K
G
Q
AI
Y
AYV
T
LN
H
-
GE
E
P
S
P
E
L
Y
AE
VR
N
W
V
RK
E
I
GP
L
A
T
P
DV
L
HWT
D
S
LP
K
T
R
SGKI
MRRI
LR
fig|444449.5.peg.3583
Escherichia coli O157:H7 str. EC4042 (90-616/652)
GD
R
TAII
W
E
G
DD
AS
QSKH
I
SY
K
ELH
RDVC
R
F
AN
TL
L
K
LGIKKGD
V
VA
IY
M
P
MV
PE
A
A
V
AM
LACA
R
IGAV
H
SV
I
FGGFSP
E
A
V
A
G
R
I
ID
S
NS
R
L
VI
TS
--
-
-
-
-
---
-
--
--------
D
E
GVR
AG
R
S
I
P
L
KKN
VD
D
AL
KN
P
N
VT
SV
E
HVVV
LK
R
TGGKIDWQEGRDLWWHD
Q
V
E
Q
A
SD
Q
HQ
A
EEM
N
A
E
D
P
L
F
IL
Y
TSG
S
TG
K
PKGVL
H
T
T
G
G
Y
L
----V
Y
A
A
-
L
TFK
YV
FDYHPG
D
I
Y
WCT
A
D
V
G
W
V
TG
HSYLLY
G
P
L
AC
GAT
T
LM
F
E
GV
PNWP
TP
A
R
MAQV
VDK
H
Q
V
N
----
I
L
YTA
P
TA
IR
A
LM
A
EG
DK
A
IEGTD
R
-
S
S
LR
I
L
G
----
SVGEP
IN
P
E
AWEWY
W
KK
I
G
N
E
KCPVV
DT
WW
Q
TET
GGFM
I
T
P
L
--
-
-
PG
AT
E
LKA
G
S
A
T
R
P
F
FGV
Q
PA
LVD
N
EGN
PL
E
G
A
T
EG
S
LV
I
TD
S
WPG
Q
A
R
TLF
GDHERFE
QT
YF
--
-
-S
T
F
K
N
M
---
--
YFSGD
GA
RRDE
D
S
Y
YW
ITGR
VD
DV
L
N
VS
G
HR
L
G
TA
EIES
A
L
VA
HPKI
A
E
A
A
VVGIP
H
N
I
K
G
Q
AI
Y
AYV
T
LN
H
-
GE
E
P
S
P
E
L
Y
AE
VR
N
W
V
RK
E
I
GP
L
A
T
P
DV
L
HWT
D
S
LP
K
T
R
SGKI
MRRI
LR
fig|444448.5.peg.2340
Escherichia coli O157:H7 str. EC4045 (90-616/652)
GD
R
TAII
W
E
G
DD
AS
QSKH
I
SY
K
ELH
RDVC
R
F
AN
TL
L
K
LGIKKGD
V
VA
IY
M
P
MV
PE
A
A
V
AM
LACA
R
IGAV
H
SV
I
FGGFSP
E
A
V
A
G
R
I
ID
S
NS
R
L
VI
TS
--
-
-
-
-
---
-
--
--------
D
E
GVR
AG
R
S
I
P
L
KKN
VD
D
AL
KN
P
N
VT
SV
E
HVVV
LK
R
TGGKIDWQEGRDLWWHD
Q
V
E
Q
A
SD
Q
HQ
A
EEM
N
A
E
D
P
L
F
IL
Y
TSG
S
TG
K
PKGVL
H
T
T
G
G
Y
L
----V
Y
A
A
-
L
TFK
YV
FDYHPG
D
I
Y
WCT
A
D
V
G
W
V
TG
HSYLLY
G
P
L
AC
GAT
T
LM
F
E
GV
PNWP
TP
A
R
MAQV
VDK
H
Q
V
N
----
I
L
YTA
P
TA
IR
A
LM
A
EG
DK
A
IEGTD
R
-
S
S
LR
I
L
G
----
SVGEP
IN
P
E
AWEWY
W
KK
I
G
N
E
KCPVV
DT
WW
Q
TET
GGFM
I
T
P
L
--
-
-
PG
AT
E
LKA
G
S
A
T
R
P
F
FGV
Q
PA
LVD
N
EGN
PL
E
G
A
T
EG
S
LV
I
TD
S
WPG
Q
A
R
TLF
GDHERFE
QT
YF
--
-
-S
T
F
K
N
M
---
--
YFSGD
GA
RRDE
D
S
Y
YW
ITGR
VD
DV
L
N
VS
G
HR
L
G
TA
EIES
A
L
VA
HPKI
A
E
A
A
VVGIP
H
N
I
K
G
Q
AI
Y
AYV
T
LN
H
-
GE
E
P
S
P
E
L
Y
AE
VR
N
W
V
RK
E
I
GP
L
A
T
P
DV
L
HWT
D
S
LP
K
T
R
SGKI
MRRI
LR
fig|444453.5.peg.1977
Escherichia coli O157:H7 str. EC4076 (90-616/652)
GD
R
TAII
W
E
G
DD
AS
QSKH
I
SY
K
ELH
RDVC
R
F
AN
TL
L
K
LGIKKGD
V
VA
IY
M
P
MV
PE
A
A
V
AM
LACA
R
IGAV
H
SV
I
FGGFSP
E
A
V
A
G
R
I
ID
S
NS
R
L
VI
TS
--
-
-
-
-
---
-
--
--------
D
E
GVR
AG
R
S
I
P
L
KKN
VD
D
AL
KN
P
N
VT
SV
E
HVVV
LK
R
TGGKIDWQEGRDLWWHD
Q
V
E
Q
A
SD
Q
HQ
A
EEM
N
A
E
D
P
L
F
IL
Y
TSG
S
TG
K
PKGVL
H
T
T
G
G
Y
L
----V
Y
A
A
-
L
TFK
YV
FDYHPG
D
I
Y
WCT
A
D
V
G
W
V
TG
HSYLLY
G
P
L
AC
GAT
T
LM
F
E
GV
PNWP
TP
A
R
MAQV
VDK
H
Q
V
N
----
I
L
YTA
P
TA
IR
A
LM
A
EG
DK
A
IEGTD
R
-
S
S
LR
I
L
G
----
SVGEP
IN
P
E
AWEWY
W
KK
I
G
N
E
KCPVV
DT
WW
Q
TET
GGFM
I
T
P
L
--
-
-
PG
AT
E
LKA
G
S
A
T
R
P
F
FGV
Q
PA
LVD
N
EGN
PL
E
G
A
T
EG
S
LV
I
TD
S
WPG
Q
A
R
TLF
GDHERFE
QT
YF
--
-
-S
T
F
K
N
M
---
--
YFSGD
GA
RRDE
D
S
Y
YW
ITGR
VD
DV
L
N
VS
G
HR
L
G
TA
EIES
A
L
VA
HPKI
A
E
A
A
VVGIP
H
N
I
K
G
Q
AI
Y
AYV
T
LN
H
-
GE
E
P
S
P
E
L
Y
AE
VR
N
W
V
RK
E
I
GP
L
A
T
P
DV
L
HWT
D
S
LP
K
T
R
SGKI
MRRI
LR
fig|444452.5.peg.1186
Escherichia coli O157:H7 str. EC4113 (90-616/652)
GD
R
TAII
W
E
G
DD
AS
QSKH
I
SY
K
ELH
RDVC
R
F
AN
TL
L
K
LGIKKGD
V
VA
IY
M
P
MV
PE
A
A
V
AM
LACA
R
IGAV
H
SV
I
FGGFSP
E
A
V
A
G
R
I
ID
S
NS
R
L
VI
TS
--
-
-
-
-
---
-
--
--------
D
E
GVR
AG
R
S
I
P
L
KKN
VD
D
AL
KN
P
N
VT
SV
E
HVVV
LK
R
TGGKIDWQEGRDLWWHD
Q
V
E
Q
A
SD
Q
HQ
A
EEM
N
A
E
D
P
L
F
IL
Y
TSG
S
TG
K
PKGVL
H
T
T
G
G
Y
L
----V
Y
A
A
-
L
TFK
YV
FDYHPG
D
I
Y
WCT
A
D
V
G
W
V
TG
HSYLLY
G
P
L
AC
GAT
T
LM
F
E
GV
PNWP
TP
A
R
MAQV
VDK
H
Q
V
N
----
I
L
YTA
P
TA
IR
A
LM
A
EG
DK
A
IEGTD
R
-
S
S
LR
I
L
G
----
SVGEP
IN
P
E
AWEWY
W
KK
I
G
N
E
KCPVV
DT
WW
Q
TET
GGFM
I
T
P
L
--
-
-
PG
AT
E
LKA
G
S
A
T
R
P
F
FGV
Q
PA
LVD
N
EGN
PL
E
G
A
T
EG
S
LV
I
TD
S
WPG
Q
A
R
TLF
GDHERFE
QT
YF
--
-
-S
T
F
K
N
M
---
--
YFSGD
GA
RRDE
D
S
Y
YW
ITGR
VD
DV
L
N
VS
G
HR
L
G
TA
EIES
A
L
VA
HPKI
A
E
A
A
VVGIP
H
N
I
K
G
Q
AI
Y
AYV
T
LN
H
-
GE
E
P
S
P
E
L
Y
AE
VR
N
W
V
RK
E
I
GP
L
A
T
P
DV
L
HWT
D
S
LP
K
T
R
SGKI
MRRI
LR
fig|444450.8.peg.5419
Escherichia coli O157:H7 str. EC4115 (90-616/652)
GD
R
TAII
W
E
G
DD
AS
QSKH
I
SY
K
ELH
RDVC
R
F
AN
TL
L
K
LGIKKGD
V
VA
IY
M
P
MV
PE
A
A
V
AM
LACA
R
IGAV
H
SV
I
FGGFSP
E
A
V
A
G
R
I
ID
S
NS
R
L
VI
TS
--
-
-
-
-
---
-
--
--------
D
E
GVR
AG
R
S
I
P
L
KKN
VD
D
AL
KN
P
N
VT
SV
E
HVVV
LK
R
TGGKIDWQEGRDLWWHD
Q
V
E
Q
A
SD
Q
HQ
A
EEM
N
A
E
D
P
L
F
IL
Y
TSG
S
TG
K
PKGVL
H
T
T
G
G
Y
L
----V
Y
A
A
-
L
TFK
YV
FDYHPG
D
I
Y
WCT
A
D
V
G
W
V
TG
HSYLLY
G
P
L
AC
GAT
T
LM
F
E
GV
PNWP
TP
A
R
MAQV
VDK
H
Q
V
N
----
I
L
YTA
P
TA
IR
A
LM
A
EG
DK
A
IEGTD
R
-
S
S
LR
I
L
G
----
SVGEP
IN
P
E
AWEWY
W
KK
I
G
N
E
KCPVV
DT
WW
Q
TET
GGFM
I
T
P
L
--
-
-
PG
AT
E
LKA
G
S
A
T
R
P
F
FGV
Q
PA
LVD
N
EGN
PL
E
G
A
T
EG
S
LV
I
TD
S
WPG
Q
A
R
TLF
GDHERFE
QT
YF
--
-
-S
T
F
K
N
M
---
--
YFSGD
GA
RRDE
D
S
Y
YW
ITGR
VD
DV
L
N
VS
G
HR
L
G
TA
EIES
A
L
VA
HPKI
A
E
A
A
VVGIP
H
N
I
K
G
Q
AI
Y
AYV
T
LN
H
-
GE
E
P
S
P
E
L
Y
AE
VR
N
W
V
RK
E
I
GP
L
A
T
P
DV
L
HWT
D
S
LP
K
T
R
SGKI
MRRI
LR
fig|444451.5.peg.2081
Escherichia coli O157:H7 str. EC4196 (90-616/652)
GD
R
TAII
W
E
G
DD
AS
QSKH
I
SY
K
ELH
RDVC
R
F
AN
TL
L
K
LGIKKGD
V
VA
IY
M
P
MV
PE
A
A
V
AM
LACA
R
IGAV
H
SV
I
FGGFSP
E
A
V
A
G
R
I
ID
S
NS
R
L
VI
TS
--
-
-
-
-
---
-
--
--------
D
E
GVR
AG
R
S
I
P
L
KKN
VD
D
AL
KN
P
N
VT
SV
E
HVVV
LK
R
TGGKIDWQEGRDLWWHD
Q
V
E
Q
A
SD
Q
HQ
A
EEM
N
A
E
D
P
L
F
IL
Y
TSG
S
TG
K
PKGVL
H
T
T
G
G
Y
L
----V
Y
A
A
-
L
TFK
YV
FDYHPG
D
I
Y
WCT
A
D
V
G
W
V
TG
HSYLLY
G
P
L
AC
GAT
T
LM
F
E
GV
PNWP
TP
A
R
MAQV
VDK
H
Q
V
N
----
I
L
YTA
P
TA
IR
A
LM
A
EG
DK
A
IEGTD
R
-
S
S
LR
I
L
G
----
SVGEP
IN
P
E
AWEWY
W
KK
I
G
N
E
KCPVV
DT
WW
Q
TET
GGFM
I
T
P
L
--
-
-
PG
AT
E
LKA
G
S
A
T
R
P
F
FGV
Q
PA
LVD
N
EGN
PL
E
G
A
T
EG
S
LV
I
TD
S
WPG
Q
A
R
TLF
GDHERFE
QT
YF
--
-
-S
T
F
K
N
M
---
--
YFSGD
GA
RRDE
D
S
Y
YW
ITGR
VD
DV
L
N
VS
G
HR
L
G
TA
EIES
A
L
VA
HPKI
A
E
A
A
VVGIP
H
N
I
K
G
Q
AI
Y
AYV
T
LN
H
-
GE
E
P
S
P
E
L
Y
AE
VR
N
W
V
RK
E
I
GP
L
A
T
P
DV
L
HWT
D
S
LP
K
T
R
SGKI
MRRI
LR
fig|444447.5.peg.2506
Escherichia coli O157:H7 str. EC4206 (90-616/652)
GD
R
TAII
W
E
G
DD
AS
QSKH
I
SY
K
ELH
RDVC
R
F
AN
TL
L
K
LGIKKGD
V
VA
IY
M
P
MV
PE
A
A
V
AM
LACA
R
IGAV
H
SV
I
FGGFSP
E
A
V
A
G
R
I
ID
S
NS
R
L
VI
TS
--
-
-
-
-
---
-
--
--------
D
E
GVR
AG
R
S
I
P
L
KKN
VD
D
AL
KN
P
N
VT
SV
E
HVVV
LK
R
TGGKIDWQEGRDLWWHD
Q
V
E
Q
A
SD
Q
HQ
A
EEM
N
A
E
D
P
L
F
IL
Y
TSG
S
TG
K
PKGVL
H
T
T
G
G
Y
L
----V
Y
A
A
-
L
TFK
YV
FDYHPG
D
I
Y
WCT
A
D
V
G
W
V
TG
HSYLLY
G
P
L
AC
GAT
T
LM
F
E
GV
PNWP
TP
A
R
MAQV
VDK
H
Q
V
N
----
I
L
YTA
P
TA
IR
A
LM
A
EG
DK
A
IEGTD
R
-
S
S
LR
I
L
G
----
SVGEP
IN
P
E
AWEWY
W
KK
I
G
N
E
KCPVV
DT
WW
Q
TET
GGFM
I
T
P
L
--
-
-
PG
AT
E
LKA
G
S
A
T
R
P
F
FGV
Q
PA
LVD
N
EGN
PL
E
G
A
T
EG
S
LV
I
TD
S
WPG
Q
A
R
TLF
GDHERFE
QT
YF
--
-
-S
T
F
K
N
M
---
--
YFSGD
GA
RRDE
D
S
Y
YW
ITGR
VD
DV
L
N
VS
G
HR
L
G
TA
EIES
A
L
VA
HPKI
A
E
A
A
VVGIP
H
N
I
K
G
Q
AI
Y
AYV
T
LN
H
-
GE
E
P
S
P
E
L
Y
AE
VR
N
W
V
RK
E
I
GP
L
A
T
P
DV
L
HWT
D
S
LP
K
T
R
SGKI
MRRI
LR
fig|478004.5.peg.2030
Escherichia coli O157:H7 str. EC4401 (90-616/652)
GD
R
TAII
W
E
G
DD
AS
QSKH
I
SY
K
ELH
RDVC
R
F
AN
TL
L
K
LGIKKGD
V
VA
IY
M
P
MV
PE
A
A
V
AM
LACA
R
IGAV
H
SV
I
FGGFSP
E
A
V
A
G
R
I
ID
S
NS
R
L
VI
TS
--
-
-
-
-
---
-
--
--------
D
E
GVR
AG
R
S
I
P
L
KKN
VD
D
AL
KN
P
N
VT
SV
E
HVVV
LK
R
TGGKIDWQEGRDLWWHD
Q
V
E
Q
A
SD
Q
HQ
A
EEM
N
A
E
D
P
L
F
IL
Y
TSG
S
TG
K
PKGVL
H
T
T
G
G
Y
L
----V
Y
A
A
-
L
TFK
YV
FDYHPG
D
I
Y
WCT
A
D
V
G
W
V
TG
HSYLLY
G
P
L
AC
GAT
T
LM
F
E
GV
PNWP
TP
A
R
MAQV
VDK
H
Q
V
N
----
I
L
YTA
P
TA
IR
A
LM
A
EG
DK
A
IEGTD
R
-
S
S
LR
I
L
G
----
SVGEP
IN
P
E
AWEWY
W
KK
I
G
N
E
KCPVV
DT
WW
Q
TET
GGFM
I
T
P
L
--
-
-
PG
AT
E
LKA
G
S
A
T
R
P
F
FGV
Q
PA
LVD
N
EGN
PL
E
G
A
T
EG
S
LV
I
TD
S
WPG
Q
A
R
TLF
GDHERFE
QT
YF
--
-
-S
T
F
K
N
M
---
--
YFSGD
GA
RRDE
D
S
Y
YW
ITGR
VD
DV
L
N
VS
G
HR
L
G
TA
EIES
A
L
VA
HPKI
A
E
A
A
VVGIP
H
N
I
K
G
Q
AI
Y
AYV
T
LN
H
-
GE
E
P
S
P
E
L
Y
AE
VR
N
W
V
RK
E
I
GP
L
A
T
P
DV
L
HWT
D
S
LP
K
T
R
SGKI
MRRI
LR
fig|478005.5.peg.560
Escherichia coli O157:H7 str. EC4486 (90-616/652)
GD
R
TAII
W
E
G
DD
AS
QSKH
I
SY
K
ELH
RDVC
R
F
AN
TL
L
K
LGIKKGD
V
VA
IY
M
P
MV
PE
A
A
V
AM
LACA
R
IGAV
H
SV
I
FGGFSP
E
A
V
A
G
R
I
ID
S
NS
R
L
VI
TS
--
-
-
-
-
---
-
--
--------
D
E
GVR
AG
R
S
I
P
L
KKN
VD
D
AL
KN
P
N
VT
SV
E
HVVV
LK
R
TGGKIDWQEGRDLWWHD
Q
V
E
Q
A
SD
Q
HQ
A
EEM
N
A
E
D
P
L
F
IL
Y
TSG
S
TG
K
PKGVL
H
T
T
G
G
Y
L
----V
Y
A
A
-
L
TFK
YV
FDYHPG
D
I
Y
WCT
A
D
V
G
W
V
TG
HSYLLY
G
P
L
AC
GAT
T
LM
F
E
GV
PNWP
TP
A
R
MAQV
VDK
H
Q
V
N
----
I
L
YTA
P
TA
IR
A
LM
A
EG
DK
A
IEGTD
R
-
S
S
LR
I
L
G
----
SVGEP
IN
P
E
AWEWY
W
KK
I
G
N
E
KCPVV
DT
WW
Q
TET
GGFM
I
T
P
L
--
-
-
PG
AT
E
LKA
G
S
A
T
R
P
F
FGV
Q
PA
LVD
N
EGN
PL
E
G
A
T
EG
S
LV
I
TD
S
WPG
Q
A
R
TLF
GDHERFE
QT
YF
--
-
-S
T
F
K
N
M
---
--
YFSGD
GA
RRDE
D
S
Y
YW
ITGR
VD
DV
L
N
VS
G
HR
L
G
TA
EIES
A
L
VA
HPKI
A
E
A
A
VVGIP
H
N
I
K
G
Q
AI
Y
AYV
T
LN
H
-
GE
E
P
S
P
E
L
Y
AE
VR
N
W
V
RK
E
I
GP
L
A
T
P
DV
L
HWT
D
S
LP
K
T
R
SGKI
MRRI
LR
fig|478006.5.peg.1442
Escherichia coli O157:H7 str. EC4501 (90-616/652)
GD
R
TAII
W
E
G
DD
AS
QSKH
I
SY
K
ELH
RDVC
R
F
AN
TL
L
K
LGIKKGD
V
VA
IY
M
P
MV
PE
A
A
V
AM
LACA
R
IGAV
H
SV
I
FGGFSP
E
A
V
A
G
R
I
ID
S
NS
R
L
VI
TS
--
-
-
-
-
---
-
--
--------
D
E
GVR
AG
R
S
I
P
L
KKN
VD
D
AL
KN
P
N
VT
SV
E
HVVV
LK
R
TGGKIDWQEGRDLWWHD
Q
V
E
Q
A
SD
Q
HQ
A
EEM
N
A
E
D
P
L
F
IL
Y
TSG
S
TG
K
PKGVL
H
T
T
G
G
Y
L
----V
Y
A
A
-
L
TFK
YV
FDYHPG
D
I
Y
WCT
A
D
V
G
W
V
TG
HSYLLY
G
P
L
AC
GAT
T
LM
F
E
GV
PNWP
TP
A
R
MAQV
VDK
H
Q
V
N
----
I
L
YTA
P
TA
IR
A
LM
A
EG
DK
A
IEGTD
R
-
S
S
LR
I
L
G
----
SVGEP
IN
P
E
AWEWY
W
KK
I
G
N
E
KCPVV
DT
WW
Q
TET
GGFM
I
T
P
L
--
-
-
PG
AT
E
LKA
G
S
A
T
R
P
F
FGV
Q
PA
LVD
N
EGN
PL
E
G
A
T
EG
S
LV
I
TD
S
WPG
Q
A
R
TLF
GDHERFE
QT
YF
--
-
-S
T
F
K
N
M
---
--
YFSGD
GA
RRDE
D
S
Y
YW
ITGR
VD
DV
L
N
VS
G
HR
L
G
TA
EIES
A
L
VA
HPKI
A
E
A
A
VVGIP
H
N
I
K
G
Q
AI
Y
AYV
T
LN
H
-
GE
E
P
S
P
E
L
Y
AE
VR
N
W
V
RK
E
I
GP
L
A
T
P
DV
L
HWT
D
S
LP
K
T
R
SGKI
MRRI
LR
fig|478007.5.peg.1095
Escherichia coli O157:H7 str. EC508 (90-616/652)
GD
R
TAII
W
E
G
DD
AS
QSKH
I
SY
K
ELH
RDVC
R
F
AN
TL
L
K
LGIKKGD
V
VA
IY
M
P
MV
PE
A
A
V
AM
LACA
R
IGAV
H
SV
I
FGGFSP
E
A
V
A
G
R
I
ID
S
NS
R
L
VI
TS
--
-
-
-
-
---
-
--
--------
D
E
GVR
AG
R
S
I
P
L
KKN
VD
D
AL
KN
P
N
VT
SV
E
HVVV
LK
R
TGGKIDWQEGRDLWWHD
Q
V
E
Q
A
SD
Q
HQ
A
EEM
N
A
E
D
P
L
F
IL
Y
TSG
S
TG
K
PKGVL
H
T
T
G
G
Y
L
----V
Y
A
A
-
L
TFK
YV
FDYHPG
D
I
Y
WCT
A
D
V
G
W
V
TG
HSYLLY
G
P
L
AC
GAT
T
LM
F
E
GV
PNWP
TP
A
R
MAQV
VDK
H
Q
V
N
----
I
L
YTA
P
TA
IR
A
LM
A
EG
DK
A
IEGTD
R
-
S
S
LR
I
L
G
----
SVGEP
IN
P
E
AWEWY
W
KK
I
G
N
E
KCPVV
DT
WW
Q
TET
GGFM
I
T
P
L
--
-
-
PG
AT
E
LKA
G
S
A
T
R
P
F
FGV
Q
PA
LVD
N
EGN
PL
E
G
A
T
EG
S
LV
I
TD
S
WPG
Q
A
R
TLF
GDHERFE
QT
YF
--
-
-S
T
F
K
N
M
---
--
YFSGD
GA
RRDE
D
S
Y
YW
ITGR
VD
DV
L
N
VS
G
HR
L
G
TA
EIES
A
L
VA
HPKI
A
E
A
A
VVGIP
H
N
I
K
G
Q
AI
Y
AYV
T
LN
H
-
GE
E
P
S
P
E
L
Y
AE
VR
N
W
V
RK
E
I
GP
L
A
T
P
DV
L
HWT
D
S
LP
K
T
R
SGKI
MRRI
LR
fig|478008.5.peg.91
Escherichia coli O157:H7 str. EC869 (90-616/652)
GD
R
TAII
W
E
G
DD
AS
QSKH
I
SY
K
ELH
RDVC
R
F
AN
TL
L
K
LGIKKGD
V
VA
IY
M
P
MV
PE
A
A
V
AM
LACA
R
IGAV
H
SV
I
FGGFSP
E
A
V
A
G
R
I
ID
S
NS
R
L
VI
TS
--
-
-
-
-
---
-
--
--------
D
E
GVR
AG
R
S
I
P
L
KKN
VD
D
AL
KN
P
N
VT
SV
E
HVVV
LK
R
TGGKIDWQEGRDLWWHD
Q
V
E
Q
A
SD
Q
HQ
A
EEM
N
A
E
D
P
L
F
IL
Y
TSG
S
TG
K
PKGVL
H
T
T
G
G
Y
L
----V
Y
A
A
-
L
TFK
YV
FDYHPG
D
I
Y
WCT
A
D
V
G
W
V
TG
HSYLLY
G
P
L
AC
GAT
T
LM
F
E
GV
PNWP
TP
A
R
MAQV
VDK
H
Q
V
N
----
I
L
YTA
P
TA
IR
A
LM
A
EG
DK
A
IEGTD
R
-
S
S
LR
I
L
G
----
SVGEP
IN
P
E
AWEWY
W
KK
I
G
N
E
KCPVV
DT
WW
Q
TET
GGFM
I
T
P
L
--
-
-
PG
AT
E
LKA
G
S
A
T
R
P
F
FGV
Q
PA
LVD
N
EGN
PL
E
G
A
T
EG
S
LV
I
TD
S
WPG
Q
A
R
TLF
GDHERFE
QT
YF
--
-
-S
T
F
K
N
M
---
--
YFSGD
GA
RRDE
D
S
Y
YW
ITGR
VD
DV
L
N
VS
G
HR
L
G
TA
EIES
A
L
VA
HPKI
A
E
A
A
VVGIP
H
N
I
K
G
Q
AI
Y
AYV
T
LN
H
-
GE
E
P
S
P
E
L
Y
AE
VR
N
W
V
RK
E
I
GP
L
A
T
P
DV
L
HWT
D
S
LP
K
T
R
SGKI
MRRI
LR
fig|637388.3.peg.2305
Escherichia coli O157:H7 str. FRIK2000 (90-616/652)
GD
R
TAII
W
E
G
DD
AS
QSKH
I
SY
K
ELH
RDVC
R
F
AN
TL
L
K
LGIKKGD
V
VA
IY
M
P
MV
PE
A
A
V
AM
LACA
R
IGAV
H
SV
I
FGGFSP
E
A
V
A
G
R
I
ID
S
NS
R
L
VI
TS
--
-
-
-
-
---
-
--
--------
D
E
GVR
AG
R
S
I
P
L
KKN
VD
D
AL
KN
P
N
VT
SV
E
HVVV
LK
R
TGGKIDWQEGRDLWWHD
Q
V
E
Q
A
SD
Q
HQ
A
EEM
N
A
E
D
P
L
F
IL
Y
TSG
S
TG
K
PKGVL
H
T
T
G
G
Y
L
----V
Y
A
A
-
L
TFK
YV
FDYHPG
D
I
Y
WCT
A
D
V
G
W
V
TG
HSYLLY
G
P
L
AC
GAT
T
LM
F
E
GV
PNWP
TP
A
R
MAQV
VDK
H
Q
V
N
----
I
L
YTA
P
TA
IR
A
LM
A
EG
DK
A
IEGTD
R
-
S
S
LR
I
L
G
----
SVGEP
IN
P
E
AWEWY
W
KK
I
G
N
E
KCPVV
DT
WW
Q
TET
GGFM
I
T
P
L
--
-
-
PG
AT
E
LKA
G
S
A
T
R
P
F
FGV
Q
PA
LVD
N
EGN
PL
E
G
A
T
EG
S
LV
I
TD
S
WPG
Q
A
R
TLF
GDHERFE
QT
YF
--
-
-S
T
F
K
N
M
---
--
YFSGD
GA
RRDE
D
S
Y
YW
ITGR
VD
DV
L
N
VS
G
HR
L
G
TA
EIES
A
L
VA
HPKI
A
E
A
A
VVGIP
H
N
I
K
G
Q
AI
Y
AYV
T
LN
H
-
GE
E
P
S
P
E
L
Y
AE
VR
N
W
V
RK
E
I
GP
L
A
T
P
DV
L
HWT
D
S
LP
K
T
R
SGKI
MRRI
LR
fig|570506.3.peg.1418
Escherichia coli O157:H7 str. FRIK966 (90-616/652)
GD
R
TAII
W
E
G
DD
AS
QSKH
I
SY
K
ELH
RDVC
R
F
AN
TL
L
K
LGIKKGD
V
VA
IY
M
P
MV
PE
A
A
V
AM
LACA
R
IGAV
H
SV
I
FGGFSP
E
A
V
A
G
R
I
ID
S
NS
R
L
VI
TS
--
-
-
-
-
---
-
--
--------
D
E
GVR
AG
R
S
I
P
L
KKN
VD
D
AL
KN
P
N
VT
SV
E
HVVV
LK
R
TGGKIDWQEGRDLWWHD
Q
V
E
Q
A
SD
Q
HQ
A
EEM
N
A
E
D
P
L
F
IL
Y
TSG
S
TG
K
PKGVL
H
T
T
G
G
Y
L
----V
Y
A
A
-
L
TFK
YV
FDYHPG
D
I
Y
WCT
A
D
V
G
W
V
TG
HSYLLY
G
P
L
AC
GAT
T
LM
F
E
GV
PNWP
TP
A
R
MAQV
VDK
H
Q
V
N
----
I
L
YTA
P
TA
IR
A
LM
A
EG
DK
A
IEGTD
R
-
S
S
LR
I
L
G
----
SVGEP
IN
P
E
AWEWY
W
KK
I
G
N
E
KCPVV
DT
WW
Q
TET
GGFM
I
T
P
L
--
-
-
PG
AT
E
LKA
G
S
A
T
R
P
F
FGV
Q
PA
LVD
N
EGN
PL
E
G
A
T
EG
S
LV
I
TD
S
WPG
Q
A
R
TLF
GDHERFE
QT
YF
--
-
-S
T
F
K
N
M
---
--
YFSGD
GA
RRDE
D
S
Y
YW
ITGR
VD
DV
L
N
VS
G
HR
L
G
TA
EIES
A
L
VA
HPKI
A
E
A
A
VVGIP
H
N
I
K
G
Q
AI
Y
AYV
T
LN
H
-
GE
E
P
S
P
E
L
Y
AE
VR
N
W
V
RK
E
I
GP
L
A
T
P
DV
L
HWT
D
S
LP
K
T
R
SGKI
MRRI
LR
fig|386585.9.peg.5277
Escherichia coli O157:H7 str. Sakai (90-616/652)
GD
R
TAII
W
E
G
DD
AS
QSKH
I
SY
K
ELH
RDVC
R
F
AN
TL
L
K
LGIKKGD
V
VA
IY
M
P
MV
PE
A
A
V
AM
LACA
R
IGAV
H
SV
I
FGGFSP
E
A
V
A
G
R
I
ID
S
NS
R
L
VI
TS
--
-
-
-
-
---
-
--
--------
D
E
GVR
AG
R
S
I
P
L
KKN
VD
D
AL
KN
P
N
VT
SV
E
HVVV
LK
R
TGGKIDWQEGRDLWWHD
Q
V
E
Q
A
SD
Q
HQ
A
EEM
N
A
E
D
P
L
F
IL
Y
TSG
S
TG
K
PKGVL
H
T
T
G
G
Y
L
----V
Y
A
A
-
L
TFK
YV
FDYHPG
D
I
Y
WCT
A
D
V
G
W
V
TG
HSYLLY
G
P
L
AC
GAT
T
LM
F
E
GV
PNWP
TP
A
R
MAQV
VDK
H
Q
V
N
----
I
L
YTA
P
TA
IR
A
LM
A
EG
DK
A
IEGTD
R
-
S
S
LR
I
L
G
----
SVGEP
IN
P
E
AWEWY
W
KK
I
G
N
E
KCPVV
DT
WW
Q
TET
GGFM
I
T
P
L
--
-
-
PG
AT
E
LKA
G
S
A
T
R
P
F
FGV
Q
PA
LVD
N
EGN
PL
E
G
A
T
EG
S
LV
I
TD
S
WPG
Q
A
R
TLF
GDHERFE
QT
YF
--
-
-S
T
F
K
N
M
---
--
YFSGD
GA
RRDE
D
S
Y
YW
ITGR
VD
DV
L
N
VS
G
HR
L
G
TA
EIES
A
L
VA
HPKI
A
E
A
A
VVGIP
H
N
I
K
G
Q
AI
Y
AYV
T
LN
H
-
GE
E
P
S
P
E
L
Y
AE
VR
N
W
V
RK
E
I
GP
L
A
T
P
DV
L
HWT
D
S
LP
K
T
R
SGKI
MRRI
LR
fig|544404.4.peg.5231
Escherichia coli O157:H7 str. TW14359 (90-616/652)
GD
R
TAII
W
E
G
DD
AS
QSKH
I
SY
K
ELH
RDVC
R
F
AN
TL
L
K
LGIKKGD
V
VA
IY
M
P
MV
PE
A
A
V
AM
LACA
R
IGAV
H
SV
I
FGGFSP
E
A
V
A
G
R
I
ID
S
NS
R
L
VI
TS
--
-
-
-
-
---
-
--
--------
D
E
GVR
AG
R
S
I
P
L
KKN
VD
D
AL
KN
P
N
VT
SV
E
HVVV
LK
R
TGGKIDWQEGRDLWWHD
Q
V
E
Q
A
SD
Q
HQ
A
EEM
N
A
E
D
P
L
F
IL
Y
TSG
S
TG
K
PKGVL
H
T
T
G
G
Y
L
----V
Y
A
A
-
L
TFK
YV
FDYHPG
D
I
Y
WCT
A
D
V
G
W
V
TG
HSYLLY
G
P
L
AC
GAT
T
LM
F
E
GV
PNWP
TP
A
R
MAQV
VDK
H
Q
V
N
----
I
L
YTA
P
TA
IR
A
LM
A
EG
DK
A
IEGTD
R
-
S
S
LR
I
L
G
----
SVGEP
IN
P
E
AWEWY
W
KK
I
G
N
E
KCPVV
DT
WW
Q
TET
GGFM
I
T
P
L
--
-
-
PG
AT
E
LKA
G
S
A
T
R
P
F
FGV
Q
PA
LVD
N
EGN
PL
E
G
A
T
EG
S
LV
I
TD
S
WPG
Q
A
R
TLF
GDHERFE
QT
YF
--
-
-S
T
F
K
N
M
---
--
YFSGD
GA
RRDE
D
S
Y
YW
ITGR
VD
DV
L
N
VS
G
HR
L
G
TA
EIES
A
L
VA
HPKI
A
E
A
A
VVGIP
H
N
I
K
G
Q
AI
Y
AYV
T
LN
H
-
GE
E
P
S
P
E
L
Y
AE
VR
N
W
V
RK
E
I
GP
L
A
T
P
DV
L
HWT
D
S
LP
K
T
R
SGKI
MRRI
LR
fig|502346.5.peg.1592
Escherichia coli O157:H7 str. TW14588 (90-616/652)
GD
R
TAII
W
E
G
DD
AS
QSKH
I
SY
K
ELH
RDVC
R
F
AN
TL
L
K
LGIKKGD
V
VA
IY
M
P
MV
PE
A
A
V
AM
LACA
R
IGAV
H
SV
I
FGGFSP
E
A
V
A
G
R
I
ID
S
NS
R
L
VI
TS
--
-
-
-
-
---
-
--
--------
D
E
GVR
AG
R
S
I
P
L
KKN
VD
D
AL
KN
P
N
VT
SV
E
HVVV
LK
R
TGGKIDWQEGRDLWWHD
Q
V
E
Q
A
SD
Q
HQ
A
EEM
N
A
E
D
P
L
F
IL
Y
TSG
S
TG
K
PKGVL
H
T
T
G
G
Y
L
----V
Y
A
A
-
L
TFK
YV
FDYHPG
D
I
Y
WCT
A
D
V
G
W
V
TG
HSYLLY
G
P
L
AC
GAT
T
LM
F
E
GV
PNWP
TP
A
R
MAQV
VDK
H
Q
V
N
----
I
L
YTA
P
TA
IR
A
LM
A
EG
DK
A
IEGTD
R
-
S
S
LR
I
L
G
----
SVGEP
IN
P
E
AWEWY
W
KK
I
G
N
E
KCPVV
DT
WW
Q
TET
GGFM
I
T
P
L
--
-
-
PG
AT
E
LKA
G
S
A
T
R
P
F
FGV
Q
PA
LVD
N
EGN
PL
E
G
A
T
EG
S
LV
I
TD
S
WPG
Q
A
R
TLF
GDHERFE
QT
YF
--
-
-S
T
F
K
N
M
---
--
YFSGD
GA
RRDE
D
S
Y
YW
ITGR
VD
DV
L
N
VS
G
HR
L
G
TA
EIES
A
L
VA
HPKI
A
E
A
A
VVGIP
H
N
I
K
G
Q
AI
Y
AYV
T
LN
H
-
GE
E
P
S
P
E
L
Y
AE
VR
N
W
V
RK
E
I
GP
L
A
T
P
DV
L
HWT
D
S
LP
K
T
R
SGKI
MRRI
LR
fig|701177.3.peg.4897
Escherichia coli O55:H7 str. CB9615 (90-616/652)
GD
R
TAII
W
E
G
DD
AS
QSKH
I
SY
K
ELH
RDVC
R
F
AN
TL
L
K
LGIKKGD
V
VA
IY
M
P
MV
PE
A
A
V
AM
LACA
R
IGAV
H
SV
I
FGGFSP
E
A
V
A
G
R
I
ID
S
NS
R
L
VI
TS
--
-
-
-
-
---
-
--
--------
D
E
GVR
AG
R
S
I
P
L
KKN
VD
D
AL
KN
P
N
VT
SV
E
HVVV
LK
R
TGGKIDWQEGRDLWWHD
Q
V
E
Q
A
SD
Q
HQ
A
EEM
N
A
E
D
P
L
F
IL
Y
TSG
S
TG
K
PKGVL
H
T
T
G
G
Y
L
----V
Y
A
A
-
L
TFK
YV
FDYHPG
D
I
Y
WCT
A
D
V
G
W
V
TG
HSYLLY
G
P
L
AC
GAT
T
LM
F
E
GV
PNWP
TP
A
R
MAQV
VDK
H
Q
V
N
----
I
L
YTA
P
TA
IR
A
LM
A
EG
DK
A
IEGTD
R
-
S
S
LR
I
L
G
----
SVGEP
IN
P
E
AWEWY
W
KK
I
G
N
E
KCPVV
DT
WW
Q
TET
GGFM
I
T
P
L
--
-
-
PG
AT
E
LKA
G
S
A
T
R
P
F
FGV
Q
PA
LVD
N
EGN
PL
E
G
A
T
EG
S
LV
I
TD
S
WPG
Q
A
R
TLF
GDHERFE
QT
YF
--
-
-S
T
F
K
N
M
---
--
YFSGD
GA
RRDE
D
S
Y
YW
ITGR
VD
DV
L
N
VS
G
HR
L
G
TA
EIES
A
L
VA
HPKI
A
E
A
A
VVGIP
H
N
I
K
G
Q
AI
Y
AYV
T
LN
H
-
GE
E
P
S
P
E
L
Y
AE
VR
N
W
V
RK
E
I
GP
L
A
T
P
DV
L
HWT
D
S
LP
K
T
R
SGKI
MRRI
LR
fig|656379.3.peg.446
Escherichia coli FVEC1302 (90-616/652)
GD
R
TAII
W
E
G
DD
AS
QSKH
I
SY
K
ELH
RDVC
R
F
AN
TL
L
E
LGIKKGD
V
VA
IY
M
P
MV
PE
A
A
V
AM
LACA
R
IGAV
H
SV
I
FGGFSP
E
A
V
A
G
R
I
ID
S
NS
R
L
VI
TS
--
-
-
-
-
---
-
--
--------
D
E
GVR
AG
R
S
I
P
L
KKN
VD
D
AL
KN
P
N
VP
S
I
E
HVVV
LK
R
TGGKIDWQEGRDLWWHDL
I
E
Q
A
SD
Q
HQ
A
EEM
N
A
E
D
P
L
F
IL
Y
TSG
S
TG
K
PKGVL
H
T
T
G
G
Y
L
----V
Y
A
A
-
L
TFK
YV
FDYHPG
D
I
Y
WCT
A
D
V
G
W
V
TG
HSYLLY
G
P
L
AC
GAT
T
LM
F
E
GV
PNWP
TP
A
R
MAQV
VDK
H
Q
V
N
----
I
L
YTA
P
TA
IR
A
LM
A
EG
DK
A
IEGTD
R
-
S
S
LR
I
L
G
----
SVGEP
IN
P
E
AWEWY
W
KK
I
G
N
E
KCPVV
DT
WW
Q
TET
GGFM
I
T
P
L
--
-
-
PG
AT
E
LKA
G
S
A
T
R
P
F
FGV
Q
PA
LVD
N
EGN
PL
E
G
A
T
EG
S
LV
I
TD
S
WPG
Q
A
R
TLF
GDHERFE
QT
YF
--
-
-S
T
F
K
N
M
---
--
YFSGD
GA
RRDE
D
GY
YW
ITGR
VD
DV
L
N
VS
G
HR
L
G
TA
EIES
A
L
VA
HPKI
A
E
A
A
VVGIP
H
N
I
K
G
Q
AI
Y
AYV
T
LN
H
-
GE
E
P
S
P
E
L
Y
AE
VR
N
W
V
RK
E
I
GP
L
A
T
P
DV
L
HWT
D
S
LP
K
T
R
SGKI
MRRI
LR
fig|656380.3.peg.438
Escherichia coli FVEC1412 (90-616/652)
GD
R
TAII
W
E
G
DD
AS
QSKH
I
SY
K
ELH
RDVC
R
F
AN
TL
L
E
LGIKKGD
V
VA
IY
M
P
MV
PE
A
A
V
AM
LACA
R
IGAV
H
SV
I
FGGFSP
E
A
V
A
G
R
I
ID
S
NS
R
L
VI
TS
--
-
-
-
-
---
-
--
--------
D
E
GVR
AG
R
S
I
P
L
KKN
VD
D
AL
KN
P
N
VP
S
I
E
HVVV
LK
R
TGGKIDWQEGRDLWWHDL
I
E
Q
A
SD
Q
HQ
A
EEM
N
A
E
D
P
L
F
IL
Y
TSG
S
TG
K
PKGVL
H
T
T
G
G
Y
L
----V
Y
A
A
-
L
TFK
YV
FDYHPG
D
I
Y
WCT
A
D
V
G
W
V
TG
HSYLLY
G
P
L
AC
GAT
T
LM
F
E
GV
PNWP
TP
A
R
MAQV
VDK
H
Q
V
N
----
I
L
YTA
P
TA
IR
A
LM
A
EG
DK
A
IEGTD
R
-
S
S
LR
I
L
G
----
SVGEP
IN
P
E
AWEWY
W
KK
I
G
N
E
KCPVV
DT
WW
Q
TET
GGFM
I
T
P
L
--
-
-
PG
AT
E
LKA
G
S
A
T
R
P
F
FGV
Q
PA
LVD
N
EGN
PL
E
G
A
T
EG
S
LV
I
TD
S
WPG
Q
A
R
TLF
GDHERFE
QT
YF
--
-
-S
T
F
K
N
M
---
--
YFSGD
GA
RRDE
D
GY
YW
ITGR
VD
DV
L
N
VS
G
HR
L
G
TA
EIES
A
L
VA
HPKI
A
E
A
A
VVGIP
H
N
I
K
G
Q
AI
Y
AYV
T
LN
H
-
GE
E
P
S
P
E
L
Y
AE
VR
N
W
V
RK
E
I
GP
L
A
T
P
DV
L
HWT
D
S
LP
K
T
R
SGKI
MRRI
LR
fig|749549.3.peg.1602
Escherichia coli MS 198-1 (90-616/652)
GD
R
TAII
W
E
G
DD
AS
QSKH
I
SY
K
ELH
RDVC
R
F
AN
TL
L
E
LGIKKGD
V
VA
IY
M
P
MV
PE
A
A
V
AM
LACA
R
IGAV
H
SV
I
FGGFSP
E
A
V
A
G
R
I
ID
S
NS
R
L
VI
TS
--
-
-
-
-
---
-
--
--------
D
E
GVR
AG
R
S
I
P
L
KKN
VD
D
AL
KN
P
N
VP
S
I
E
HVVV
LK
R
TGGKIDWQEGRDLWWHDL
I
E
Q
A
SD
Q
HQ
A
EEM
N
A
E
D
P
L
F
IL
Y
TSG
S
TG
K
PKGVL
H
T
T
G
G
Y
L
----V
Y
A
A
-
L
TFK
YV
FDYHPG
D
I
Y
WCT
A
D
V
G
W
V
TG
HSYLLY
G
P
L
AC
GAT
T
LM
F
E
GV
PNWP
TP
A
R
MAQV
VDK
H
Q
V
N
----
I
L
YTA
P
TA
IR
A
LM
A
EG
DK
A
IEGTD
R
-
S
S
LR
I
L
G
----
SVGEP
IN
P
E
AWEWY
W
KK
I
G
N
E
KCPVV
DT
WW
Q
TET
GGFM
I
T
P
L
--
-
-
PG
AT
E
LKA
G
S
A
T
R
P
F
FGV
Q
PA
LVD
N
EGN
PL
E
G
A
T
EG
S
LV
I
TD
S
WPG
Q
A
R
TLF
GDHERFE
QT
YF
--
-
-S
T
F
K
N
M
---
--
YFSGD
GA
RRDE
D
GY
YW
ITGR
VD
DV
L
N
VS
G
HR
L
G
TA
EIES
A
L
VA
HPKI
A
E
A
A
VVGIP
H
N
I
K
G
Q
AI
Y
AYV
T
LN
H
-
GE
E
P
S
P
E
L
Y
AE
VR
N
W
V
RK
E
I
GP
L
A
T
P
DV
L
HWT
D
S
LP
K
T
R
SGKI
MRRI
LR
fig|585056.7.peg.4769
Escherichia coli UMN026 (90-616/652)
GD
R
TAII
W
E
G
DD
AS
QSKH
I
SY
K
ELH
RDVC
R
F
AN
TL
L
E
LGIKKGD
V
VA
IY
M
P
MV
PE
A
A
V
AM
LACA
R
IGAV
H
SV
I
FGGFSP
E
A
V
A
G
R
I
ID
S
NS
R
L
VI
TS
--
-
-
-
-
---
-
--
--------
D
E
GVR
AG
R
S
I
P
L
KKN
VD
D
AL
KN
P
N
VP
S
I
E
HVVV
LK
R
TGGKIDWQEGRDLWWHDL
I
E
Q
A
SD
Q
HQ
A
EEM
N
A
E
D
P
L
F
IL
Y
TSG
S
TG
K
PKGVL
H
T
T
G
G
Y
L
----V
Y
A
A
-
L
TFK
YV
FDYHPG
D
I
Y
WCT
A
D
V
G
W
V
TG
HSYLLY
G
P
L
AC
GAT
T
LM
F
E
GV
PNWP
TP
A
R
MAQV
VDK
H
Q
V
N
----
I
L
YTA
P
TA
IR
A
LM
A
EG
DK
A
IEGTD
R
-
S
S
LR
I
L
G
----
SVGEP
IN
P
E
AWEWY
W
KK
I
G
N
E
KCPVV
DT
WW
Q
TET
GGFM
I
T
P
L
--
-
-
PG
AT
E
LKA
G
S
A
T
R
P
F
FGV
Q
PA
LVD
N
EGN
PL
E
G
A
T
EG
S
LV
I
TD
S
WPG
Q
A
R
TLF
GDHERFE
QT
YF
--
-
-S
T
F
K
N
M
---
--
YFSGD
GA
RRDE
D
GY
YW
ITGR
VD
DV
L
N
VS
G
HR
L
G
TA
EIES
A
L
VA
HPKI
A
E
A
A
VVGIP
H
N
I
K
G
Q
AI
Y
AYV
T
LN
H
-
GE
E
P
S
P
E
L
Y
AE
VR
N
W
V
RK
E
I
GP
L
A
T
P
DV
L
HWT
D
S
LP
K
T
R
SGKI
MRRI
LR
Consen1
Primary consensus
MDiiGgqhLrqmWddlAdvygdktAii
e
-
as
ysY
eLh
r
AN
l
lGIkkGD
vA
lp
pEf
v
lacakIGAv
vpi
ee
aw
l
sqa
l
ts
--
f
p
-
q
--------
qe
qlr
I
l
---
vD
al
--
Pa
svs
lk
-------------------
qp
l
A
n
dd
a
iLfTSGttg
PKGVl
Th
n
L
Y
A
-
l
wq
Dvy
ap
gh
tg
apf
GAt
vl
e
----
tp
a
vdk
r
t
----
it
p
ir
Lm
qp
a
rls
lrf
l
----
in
e
ckk
G
e
---
ll
yg
TEt
iv
l
--
d
Pg
r
-
s
gra
fgve
lvDd
pLp
g
eGe
i
s
---
g
tlF
-------
YF
p
Tak
l
gwyfsGD
rrDE
Gy
itgR
dvi
rgGenls
EiEsil
HPKI
da
VVgipd
i
geai
AyVvLn
-
ge
lS
Ee
--
vr
f
rk
iak
k
P
l
d
LPrt
SGKI
lRKnlK
Consen2
Secondary consensus
lw
das
ady
qqt
ramphri
v
ng
gg
it
a
c
y
k
s
i
md
c
a
f
fgllr
i
svl
aa
vg
i
cns
m
--
aq
-
-
t
-
pvdlilpldn
agq
gkknt
lakn
n
gle
ia
tggkidwqegrdlwwhdlv
ta
q
ee
l
v
y
ses
t
g
r
-
yv
if
md
fw
dc
gal
r
lm
d
pnwpsa
r
l
q
q
ncmlgal
y
ln
e
eg
-
--
r
vmi
gcggt
q
w
kcpvv
ww
s
vt
iig
-
l
e
gt
typ
acyq
r
n
t
e
a
i
s
-
vwpg
a
n
gdherfe
-
fr
m
--
l
t
ym
f
fvd
n
l
vs
hr
g
ai
ei
amkh
r
dqrs
f
t
k
phh
p
l
aefa
w
eq
gp
a
i
kn
i
di
Consensus 1
(when a gap)
Conservative difference
Consensus 2
(when a gap)
Nonconservative diff.
Other character