fig|1040638.4.peg.558
Escherichia coli O104:H4 str. LB226692
MNSLTANNRLSQQLVVSVAEHLLLRHECRLPNHLAVSNHRELYLTVGGELCRNLTAGFVTEEGFMSMLFVGSQKHSALSIFAKTTRMSALVLCGNSGVILLSVKDHQHIDSAIPGRYTVQAPYKAGAGIGVL
K
F
AH
A
H
NRA
S
AVFL
-RTFP
HI
QIMVGRAG
A
S
K
D
A
PGS
CA
TG
Y
ANPVRLTTS
V
IGV
P
C
G
E
FS-
K
F
A
H
E
DVT
MAT
T
PT
Q
T
H
P
K
I
D
VI
H
G
K
AVTSSLAVA
E
Y
F
C
K
Q
H
KN
V
IQ
KI
Q
TLECS
V
E
FT
EL
NF
-----
QP
S
D
Y
T
DCTGRKLPCYQITRDGFAFLAMGFTGKRAA
R
FKEAYINAFNQMEKQLS
N
PSV
L
SDVAHNASVLYSYISSIHQVWLQQLYPMLAKAESPLAVSLYD
R
INDA
A
L
LA
S
LINLSLNPSEVRGRK
fig|6666666.5357.peg.2782
Escherichia coli TY-2482
MNSLTANNRLSQQLVVSVAEHLLLRHECRLPNHLAVSNHRELYLTVGGELCRNLTAGFVTEEGFMSMLFVGSQKHSALSIFAKTTRMSALVLCGNSGVILLSVKDHQHIDSAIPGRYTVQAPYKAGAGIGVL
K
F
AH
A
H
NRA
S
AVFL
-RTFP
HI
QIMVGRAG
A
S
K
D
A
PGS
CA
TG
Y
ANPVRLTTS
V
IGV
P
C
G
E
FS-
K
F
A
H
E
DVT
MAT
T
PT
Q
T
H
P
K
I
D
VI
H
G
K
AVTSSLAVA
E
Y
F
C
K
Q
H
KN
V
IQ
KI
Q
TLECS
V
E
FT
EL
NF
-----
QP
S
D
Y
T
DCTGRKLPCYQITRDGFAFLAMGFTGKRAA
R
FKEAYINAFNQMEKQLS
N
PSV
L
SDVAHNASVLYSYISSIHQVWLQQLYPMLAKAESPLAVSLYD
R
INDA
A
L
LA
S
LINLSLNPSEVRGRK
fig|562.375.peg.2061
Escherichia coli EC4100B
MNSLTANNRLSQQLVVSVAEHLLLRHECRLPNHLAVSNHRELYLTVGGELCRNLTAGFVTEEGFMSMLFVGSQKHSALSIFAKTTRMSALVLCGNSGVILLSVKDHQHIDSAIPGRYTVQAPYKAGAGIGVL
K
F
AH
A
H
NRA
S
AVFL
-RTFP
HI
QIMVGRAG
A
S
K
D
A
PGS
CA
TG
Y
ANPVRLTTS
V
IGV
P
C
G
E
FS-
K
F
A
H
E
DVT
MAT
T
PT
Q
T
H
P
K
I
D
VI
H
G
K
AVTSSLAVA
E
Y
F
C
K
Q
H
KN
V
IQ
KI
Q
TLECS
V
E
FT
EL
NF
-----
QP
S
D
Y
T
DCTGRKLPCYQITRDGFAFLAMGFTGKRAA
R
FKEAYINAFNQMEKQLS
N
PSV
L
SDVAHNASVLYSYISSIHQVWLQQLYPMLAKAESPLAVSLYD
R
INDA
A
L
LA
S
LINLSLNPSEVRGRK
fig|344601.3.peg.1030
Escherichia coli B171
MNSLTANNRLSQQLVVSVAEHLLLRHECRLPNHLAVSNHRELYLTVGGELCRNLTAGFVTEEGFMSMLFVGSQKHSALSIFAKTTRMSALVLCGNSGVILLSVKDHQHIDSAIPGRYTVQAPYKAGAGIGVLE
K
AT
A
Y
NR
V
D
AVFL
YALFC
H
AQIMVGR
T
G
A
S
Q
D
A
P
V
R
VA
A
G
N
AN
S
VRLTTS
M
IGV
L
C
G
E
FF-
K
L
A
T
EAAIMAT
I
PT
FV
H
PEI
T
I
I
N
G
R
AVT
T
SLAVAN
Y
F
T
KRH
E
R
VL
D
R
IR
N
LECS
A
E
F
A
E
H
NF
-----
VL
S
G
Y
I
D
A
S
GRKLPCYQITRDGFAFLAMGFTGKRAAQFKEAYINAFNQMEKQLSKPSVPSDVAHNASVLYSYISSIHQVWLQQLYPML
E
KAESPLAVSLYD
R
INDA
A
F
LA
R
LI
HS
SLN
S
SEVRGRK
fig|344601.5.peg.1085
Escherichia coli B171
MNSLTANNRLSQQLVVSVAEHLLLRHECRLPNHLAVSNHRELYLTVGGELCRNLTAGFVTEEGFMSMLFVGSQKHSALSIFAKTTRMSALVLCGNSGVILLSVKDHQHIDSAIPGRYTVQAPYKAGAGIGVLE
K
AT
A
Y
NR
V
D
AVFL
YALFC
H
AQIMVGR
T
G
A
S
Q
D
A
P
V
R
VA
A
G
N
AN
S
VRLTTS
M
IGV
L
C
G
E
FF-
K
L
A
T
EAAIMAT
I
PT
FV
H
PEI
T
I
I
N
G
R
AVT
T
SLAVAN
Y
F
T
KRH
E
R
VL
D
R
IR
N
LECS
A
E
F
A
E
H
NF
-----
VL
S
G
Y
I
D
A
S
GRKLPCYQITRDGFAFLAMGFTGKRAAQFKEAYINAFNQMEKQLSKPSVPSDVAHNASVLYSYISSIHQVWLQQLYPML
E
KAESPLAVSLYD
R
INDA
A
F
LA
R
LI
HS
SLN
S
SEVRGRK
fig|358709.5.peg.1761
Escherichia coli 101-1
MNSLTANNRLSQQLVVSVAEHLLLR
Y
ECRLPNHLAVSNHRELYLTVGGELCRNLTAGFVTEEGFMSMLFVGSQKHSALSIFAKTTRMSALVLCGNSG
M
ILLSVKDHQHIDSAIPGRYTVQAPYKAGAG
R
G
NP
EF
TK
A
H
NRA
L
AVFL
CNEQH
YAQIMVGRAGP
T
S
V
GPGS
LV
TG
I
ST
PVRLTT
N
K
VVE
S
L
GG
ELL
K
I
T
K
EAAIMAT
I
PTLTQPEI
A
IVDGQAVTSSLAVANFFSKRHDDVLKKIRTLECS
A
SFTARNF
-----
SV
S
D
Y
T
DCTGRKLPCYQITRDGFAFLAMGFTGKRAAQFKEAYINAFNQMEKQLS
N
PSV
L
SDVAHNASVLYSYISSIHQVWLQQLYPMLAKAESPLAVSLYDYINDAS
A
LA
C
LINLSLNPSEVRGRK
fig|679205.4.peg.530
Escherichia coli MS 124-1
MNSLTANNRLSQQLVVSVAEHLLLRHECRLPNHLAVSNHRELYLTVGGELCRNLTAGFVTEEGFMSMLFVG
N
QKHSALSIFAKTTRMSALVLCGNSGVILLSVKDHQHIDSAIPGRYTVQAPYK
T
GAG
R
G
NP
EF
TK
A
H
NRA
L
AVFL
CHEQH
YAQIMVGRAGP
T
S
V
GPGS
LV
TG
I
ST
PVRLTT
N
K
VVE
S
L
GG
ELL
K
I
T
K
EAAIMAT
I
PTLTQPEI
A
IVDGQAVTSSLAVANFFSKRHDDVLKKIRTLECS
A
SFTARNF
-----
SV
S
D
Y
T
DCTGRKLPCYQITRDGFAFLAMGFTGKRAAQFKEAYINAFNQMEKQLS
N
PSV
L
SDVAHNASVLYSYISSIHQVWLQQLYPMLAKAESPLAVSLYDYINDAS
A
LA
C
LINLSLNPSEVRGRK
fig|749533.3.peg.694
Escherichia coli MS 84-1
MNSLTANNRLSQQLVVSVAEHLLLRHECRLPNHLAVSNHRELYLTVGGELCRNLTAGFVTEEGFMSMLFVG
N
QKHSALSIFAKTTRMSALVLCGNSGVILLSVKDHQHIDSAIPGRYTVQAPYK
T
GAG
R
G
NP
EF
TK
A
H
NRA
L
AVFL
CHEQH
YAQIMVGRAGP
T
S
V
GPGS
LV
TG
I
ST
PVRLTT
N
K
VVE
S
L
GG
ELL
K
I
T
K
EAAIMAT
I
PTLTQPEI
A
IVDGQAVTSSLAVANFFSKRHDDVLKKIRTLECS
A
SFTARNF
-----
SV
S
D
Y
T
DCTGRKLPCYQITRDGFAFLAMGFTGKRAAQFKEAYINAFNQMEKQLS
N
PSV
L
SDVAHNASVLYSYISSIHQVWLQQLYPMLAKAESPLAVSLYDYINDAS
A
LA
C
LINLSLNPSEVRGRK
fig|585397.7.peg.2151
Escherichia coli ED1a
MNSLTANNRLSQQLVVSVAEHLLLRHECRLPNHLAVSNHRELYLTVGGELCRNLTAGFVTEEGFMSMLFVGSQKHSALSIFAKTTRMSALVLCGNSGVILLSVKDHQHIDSAI
S
GRYTV
S
APYKAGAGIGVL
KL
IT
E
H
NRA
H
AVF
S
CHEHC
YAQIMVGR
T
GP
T
S
V
GPGS
VV
S
G
N
ANPVRLTTS
V
IGV
P
C
G
E
FSK
K
L
T
T
G
A
VT
M
T
T
L
PTL
S
QPEI
A
IVDGQAVTSSLAVA
D
FFSKRHDDVLKKIR
I
L
D
CS
P
E
F
C
ARNF
AETS
-
IL
V
R
Q
P
NGGT
RKLPCYQITRDGFAFLAMGFTGKRAAQFKEAYINAFNQMEKQLS
N
PSV
L
SDVAHNASVLYSYISSIHQVWLQQLYPMLAKAESPLAVSLYD
R
INDA
A
L
LA
S
LINLSLNPSEVRGRK
fig|585397.9.peg.2147
Escherichia coli ED1a
MNSLTANNRLSQQLVVSVAEHLLLRHECRLPNHLAVSNHRELYLTVGGELCRNLTAGFVTEEGFMSMLFVGSQKHSALSIFAKTTRMSALVLCGNSGVILLSVKDHQHIDSAI
S
GRYTV
S
APYKAGAGIGVL
KL
IT
E
H
NRA
H
AVF
S
CHEHC
YAQIMVGR
T
GP
T
S
V
GPGS
VV
S
G
N
ANPVRLTTS
V
IGV
P
C
G
E
FSK
K
L
T
T
G
A
VT
M
T
T
L
PTL
S
QPEI
A
IVDGQAVTSSLAVA
D
FFSKRHDDVLKKIR
I
L
D
CS
P
E
F
C
ARNF
AETS
-
IL
V
R
Q
P
NGGT
RKLPCYQITRDGFAFLAMGFTGKRAAQFKEAYINAFNQMEKQLS
N
PSV
L
SDVAHNASVLYSYISSIHQVWLQQLYPMLAKAESPLAVSLYD
R
INDA
A
L
LA
S
LINLSLNPSEVRGRK
fig|405955.13.peg.4947
Escherichia coli APEC O1
MNSLTANNRLSQQLVVSVA
A
HLLLRHECRLPNHLAVSNHRELYLTVGGELCRNLTAGFVTEE
D
FM
F
MLFVGSQKHSALSIFAKTTRMSALVLCGNSGVILLSVKDHQHIDSAIPGRYTVQAPYKAGAG
R
G
NP
EF
TK
A
H
NRA
L
AVFL
CHEQH
YAQIMVGRAGP
T
S
V
GPGS
LV
TG
I
ST
PVRLTT
N
K
VVE
S
L
GG
ELL
K
I
T
K
EAAIMAT
I
PTLTQPEI
A
IVDGQAVTSSLAVANFFSKRHDDVLKKIRTLECS
A
SFTARNF
-----
SV
S
D
Y
T
DCTGRKLPCYQITRDGFAFLAMGFTGKRAAQFKEAYINAFNQMEKQLSKP
A
VPSDVAHNASVL
C
SYISSIHQVWLQQLYPMLAKAESPLAVSLYDYINDAS
A
LA
C
LINLSLNPSEVRGRK
fig|405955.9.peg.4167
Escherichia coli APEC O1
MNSLTANNRLSQQLVVSVA
A
HLLLRHECRLPNHLAVSNHRELYLTVGGELCRNLTAGFVTEE
D
FM
F
MLFVGSQKHSALSIFAKTTRMSALVLCGNSGVILLSVKDHQHIDSAIPGRYTVQAPYKAGAG
R
G
NP
EF
TK
A
H
NRA
L
AVFL
CHEQH
YAQIMVGRAGP
T
S
V
GPGS
LV
TG
I
ST
PVRLTT
N
K
VVE
S
L
GG
ELL
K
I
T
K
EAAIMAT
I
PTLTQPEI
A
IVDGQAVTSSLAVANFFSKRHDDVLKKIRTLECS
A
SFTARNF
-----
SV
S
D
Y
T
DCTGRKLPCYQITRDGFAFLAMGFTGKRAAQFKEAYINAFNQMEKQLSKP
A
VPSDVAHNASVL
C
SYISSIHQVWLQQLYPMLAKAESPLAVSLYDYINDAS
A
LA
C
LINLSLNPSEVRGRK
fig|585035.6.peg.4906
Escherichia coli S88
MNSLTANNRLSQQLVVSVA
A
HLLLRHECRLPNHLAVSNHRELYLTVGGELCRNLTAGFVTEE
D
FM
F
MLFVGSQKHSALSIFAKTTRMSALVLCGNSGVILLSVKDHQHIDSAIPGRYTVQAPYKAGAG
R
G
NP
EF
TK
A
H
NRA
L
AVFL
CHEQH
YAQIMVGRAGP
T
S
V
GPGS
LV
TG
I
ST
PVRLTT
N
K
VVE
S
L
GG
ELL
K
I
T
K
EAAIMAT
I
PTLTQPEI
A
IVDGQAVTSSLAVANFFSKRHDDVLKKIRTLECS
A
SFTARNF
-----
SV
S
D
Y
T
DCTGRKLPCYQITRDGFAFLAMGFTGKRAAQFKEAYINAFNQMEKQLSKP
A
VPSDVAHNASVL
C
SYISSIHQVWLQQLYPMLAKAESPLAVSLYDYINDAS
A
LA
C
LINLSLNPSEVRGRK
fig|364106.7.peg.4961
Escherichia coli UTI89
MNSLTANNRLSQQLVVSVA
A
HLLLRHECRLPNHLAVSNHRELYLTVGGELCRNLTAGFVTEE
D
FM
F
MLFVGSQKHSALSIFAKTTRMSALVLCGNSGVILLSVKDHQHIDSAIPGRYTVQAPYKAGAG
R
G
NP
EF
TK
A
H
NRA
L
AVFL
CHEQH
YAQIMVGRAGP
T
S
V
GPGS
LV
TG
I
ST
PVRLTT
N
K
VVE
S
L
GG
ELL
K
I
T
K
EAAIMAT
I
PTLTQPEI
A
IVDGQAVTSSLAVANFFSKRHDDVLKKIRTLECS
A
SFTARNF
-----
SV
S
D
Y
T
DCTGRKLPCYQITRDGFAFLAMGFTGKRAAQFKEAYINAFNQMEKQLSKP
A
VPSDVAHNASVL
C
SYISSIHQVWLQQLYPMLAKAESPLAVSLYDYINDAS
A
LA
C
LINLSLNPSEVRGRK
fig|364106.8.peg.4962
Escherichia coli UTI89
MNSLTANNRLSQQLVVSVA
A
HLLLRHECRLPNHLAVSNHRELYLTVGGELCRNLTAGFVTEE
D
FM
F
MLFVGSQKHSALSIFAKTTRMSALVLCGNSGVILLSVKDHQHIDSAIPGRYTVQAPYKAGAG
R
G
NP
EF
TK
A
H
NRA
L
AVFL
CHEQH
YAQIMVGRAGP
T
S
V
GPGS
LV
TG
I
ST
PVRLTT
N
K
VVE
S
L
GG
ELL
K
I
T
K
EAAIMAT
I
PTLTQPEI
A
IVDGQAVTSSLAVANFFSKRHDDVLKKIRTLECS
A
SFTARNF
-----
SV
S
D
Y
T
DCTGRKLPCYQITRDGFAFLAMGFTGKRAAQFKEAYINAFNQMEKQLSKP
A
VPSDVAHNASVL
C
SYISSIHQVWLQQLYPMLAKAESPLAVSLYDYINDAS
A
LA
C
LINLSLNPSEVRGRK
fig|670897.3.peg.991
Escherichia coli 2362-75
MNSLTANNRLSQQLVVSVAEHLLLRHECRLPNHLAVSNHRELYLTVGGELCRNLTAGFVTEEGFMSMLFVGSQKHSALSIFAKTTRMSALVLCGNSGVILLSVKDHQHIDSAIPGRYTVQAPYKAGAGIGVL
KL
IT
E
H
NRA
H
AVF
S
CHEHC
YAQIMVGR
T
GP
T
S
V
GPGS
VV
S
G
N
ANPVRLTTS
V
IGV
P
C
G
E
FSE
K
L
T
T
G
A
VT
M
T
T
L
PTL
S
QPEI
A
IVDGQAVTSSLAVA
D
FFSKRHDDVLKKIR
I
L
D
CS
P
E
F
C
ARNF
AETS
-
IL
V
H
Q
P
NGGT
RKLPCY
H
ITRDGFAFLAMGFTGKRAAQFKEAYINAFNQMEKQLSKPSVPSDVAHNASVLYSYISSIHQVWLQQLYPML
E
KAESPLAVSLYD
R
INDA
A
F
LA
R
LI
HS
SLN
S
SEVRGRK
fig|585035.6.peg.540
Escherichia coli S88
MNSLTANNRLSQQLVVSVAEHLLLRHECRLPNHLAVSNHRELYLTVGGELCRNLTAGFVTEE
D
FM
F
MLFVGSQKHSALSIFAKTT
S
MSALVLCGNSGVILLSVKDHQHIDSAIPGRYTVQAPYKAG
V
GIGVLE
L
HT
A
T
IG
A
L
A
S
FL
LLQLS
Y
T
QIMVG
W
V
G
A
P
K
G
A
P
V
S
VC
A
G
Y
ANP
A
QF
TTS
E
IGVS
G
GG
S-Y
P
L
H
T
EAAIMAT
I
PTLTQPEI
A
IVDGQAVTSSLAVANFFSKRHDDVLKKIRTLECS
A
SFTARNF
-----
SV
S
D
Y
T
DCTGRKLPCYQITRDGFAFLAMGFTGKRAAQFKEAYINAFNQMEKQLSKP
A
VPSDVAHNASVLYSYISSIHQVWLQQLYPMLAKAESPLAVSLYDYINDAS
A
LA
C
LINLSLNPSEVRGRK
fig|562.375.peg.3087
Escherichia coli EC4100B
MNSLTANNRLSQQ
P
VVSVAEH
R
LL
W
HECRLPNHLAVSNHRELYLTVGGELCRNLTAGFVTEE
D
FM
F
MLFVGSQKHSALSIFAKTTRMSALVLCGNSGVILLSVKDHQHIDSAIPGRYTVQAPYK
T
GAG
R
G
NP
EF
TK
A
H
NRA
L
AVFL
CHEQH
YAQIMVGRAGP
T
S
V
GPGS
LV
TG
I
ST
PVRLTT
N
K
VVE
S
L
GG
ELL
K
I
T
K
EAAIMAT
I
PTLTQPEI
A
IVDGQAVTSSLAVANFFSKRHDDVLKKIRTLECS
A
SFTARNF
-----
SV
S
D
Y
T
DCTGRKLPCYQITRDGFAFLAMGFTGKRAAQFKEAYINAFNQMEKQLSKPSVPSDVAHNASVL
C
SYISSIHQVWLQQLYPMLAKAESPLAVSLYDYINDAS
A
LA
C
LINLSLNPSEV
W
GRK
fig|340185.3.peg.5239
Escherichia coli E22
MNSLTANNRLSQQLVVSVA
A
HLLLRHECRLPNHLAVSNHRELYLTVGGELCRNLTAGFVTEE
D
FM
F
MLFVGSQKHSALSIFAKTTRMSALVLCGNSGVILLSVKDHQHIDSAIPGRYTVQAPYKAGAGIGVL
KL
ST
A
M
YD
A
P
A
S
FL
SSAFA
HI
QIMVG
W
AG
A
P
K
G
A
P
V
S
VD
A
G
Y
ANPV
QF
TTS
E
IGVS
G
GG
S-F
S
L
S
T
EAAIMAT
I
QA
LTQPEI
T
I
D
N
GQAVT
T
SLAVANFFSKRHDDVLKKIRTL
D
CS
P
E
F
C
ARNF
AETS
I
SV
N
Q
P
N
G
G
T
-
RKLPCYQITRDGFAFLAMGFTGKRAA
R
FKEAYINAFNQMEK
L
LSKPS
T
L
SD
A
A
D
NASVLYS
HL
S
V
IH
K
VWLQQLYPMLAKAESPLAVSLYDYINDAS
A
LA
C
LINLSLNPSEVRGRK
fig|340185.4.peg.5549
Escherichia coli E22
MNSLTANNRLSQQLVVSVA
A
HLLLRHECRLPNHLAVSNHRELYLTVGGELCRNLTAGFVTEE
D
FM
F
MLFVGSQKHSALSIFAKTTRMSALVLCGNSGVILLSVKDHQHIDSAIPGRYTVQAPYKAGAGIGVL
KL
ST
A
M
YD
A
P
A
S
FL
SSAFA
HI
QIMVG
W
AG
A
P
K
G
A
P
V
S
VD
A
G
Y
ANPV
QF
TTS
E
IGVS
G
GG
S-F
S
L
S
T
EAAIMAT
I
QA
LTQPEI
T
I
D
N
GQAVT
T
SLAVANFFSKRHDDVLKKIRTL
D
CS
P
E
F
C
ARNF
AETS
I
SV
N
Q
P
N
G
G
T
-
RKLPCYQITRDGFAFLAMGFTGKRAA
R
FKEAYINAFNQMEK
L
LSKPS
T
L
SD
A
A
D
NASVLYS
HL
S
V
IH
K
VWLQQLYPMLAKAESPLAVSLYDYINDAS
A
LA
C
LINLSLNPSEVRGRK
Consen1
Primary consensus
MNSLTANNRLSQQLVVSVAeHLLLRHECRLPNHLAVSNHRELYLTVGGELCRNLTAGFVTEEgFMsMLFVGSQKHSALSIFAKTTRMSALVLCGNSGVILLSVKDHQHIDSAIPGRYTVQAPYKaGAGiGvlef
a
nrA
AvFl
yaQIMVGraGp
s
gPgS
tG
anPVrlTTs
igvs
Gg
k
t
eaaiMaT
PTltqPeI
ivdGqAVTsSLAVAnfFsKrHddVlkKIrtLeCS
sFtarNF
-----
s
y
dctgRKLPCYQITRDGFAFLAMGFTGKRAAqFKEAYINAFNQMEKQLSkPsVpSDVAHNASVLySYISSIHQVWLQQLYPMLaKAESPLAVSLYDyINDAs
LA
LInlSLNpSEVRGRK
Consen2
Secondary consensus
a
d
f
t
r
npkl
e
yd
s
s
hi
wt
a
k
a
v
st
qf
n
vvep
e
s
gdvt
t
qsh
k
vi
k
t
y
c
q
kn
iq
qi
d
e
cel
aets
v
q
nggt
r
n
a
l
c
e
r
a
hs
s
Consensus 1
(when a gap)
Conservative difference
Consensus 2
(when a gap)
Nonconservative diff.
Other character