fig|1040638.4.peg.5510
Escherichia coli O104:H4 str. LB226692
MATTRNKVMW
Q
EG
M
L
MR
P
H
HFQQQQRY
ND
YL
DNQ
R
FR
A
MNDLS
WGF
T
E
LTL
N
N
ELL
AQ
GKIMID
S
A
S
G
TL
PDGTVFS
I
P
DQ
D
A
LP
D
P
-
LH
P
QH
F
P
D
ER
S
RN
IYLALPV
A
S
D
V
R
NEI
-
---
S
DG
RR
IG
RY
--
R
LNYAD
VRD
L
H
SE
EGD
TRT
L
T
LG
Q
L
T
PRI
M
S
--
GAED
MS
AYITLPL
C
RI
SD
RHA
D
GSLT
L
DD
D
FIP
SC
QN
IQ
VS
KK
L
RVY
L
K
EVQ
GA
I
GG
RA
S
DLA
N
--
RI
G
S
PAQ
SG
--
IADVAEFMMLQ
L
LNR
N
Q
TR
FTH
HA
R
RSQ
LHPE
DF
Y
L
DLA
G
LLGELMTF
T
E
P
-
S
RLPC
P
L
D
-------
V
Y
D
H
H
DL
TK
TF
-
K
TL
L
PEV
K
RAL
H
TVL
S
PRA
V
NL
P
L
HLRD
G
I
-
W
---
Q
A
D
IHD
TE
LLQ
S
A
T
FVLAVAA
N
-
MP
V
DQIQ
R
QFIQQSKI
S
SPEKI
RN
MVSVQIPGI
P
L
RA
LM
V
APRQLP
Y
H
S
G
FS
YFELDK
SGQ
AW
TE
M
AA
AG
AV
ALH
V
SGSFPDLN
M
QLWAIRG
fig|6666666.5357.peg.1545
Escherichia coli TY-2482
MATTRNKVMW
Q
EG
M
L
MR
P
H
HFQQQQRY
ND
YL
DNQ
R
FR
A
MNDLS
WGF
T
E
LTL
N
N
ELL
AQ
GKIMID
S
A
S
G
TL
PDGTVFS
I
P
DQ
D
A
LP
D
P
-
LH
P
QH
F
P
D
ER
S
RN
IYLALPV
A
S
D
V
R
NEI
-
---
S
DG
RR
IG
RY
--
R
LNYAD
VRD
L
H
SE
EGD
TRT
L
T
LG
Q
L
T
PRI
M
S
--
GAED
MS
AYITLPL
C
RI
SD
RHA
D
GSLT
L
DD
D
FIP
SC
QN
IQ
VS
KK
L
RVY
L
K
EVQ
GA
I
GG
RA
S
DLA
N
--
RI
G
S
PAQ
SG
--
IADVAEFMMLQ
L
LNR
N
Q
TR
FTH
HA
R
RSQ
LHPE
DF
Y
L
DLA
G
LLGELMTF
T
E
P
-
S
RLPC
P
L
D
-------
V
Y
D
H
H
DL
TK
TF
-
K
TL
L
PEV
K
RAL
H
TVL
S
PRA
V
NL
P
L
HLRD
G
I
-
W
---
Q
A
D
IHD
TE
LLQ
S
A
T
FVLAVAA
N
-
MP
V
DQIQ
R
QFIQQSKI
S
SPEKI
RN
MVSVQIPGI
P
L
RA
LM
V
APRQLP
Y
H
S
G
FS
YFELDK
SGQ
AW
TE
M
AA
AG
AV
ALH
V
SGSFPDLN
M
QLWAIRG
fig|585055.6.peg.227
Escherichia coli 55989
MATTRNKVMW
Q
EG
M
L
MR
P
H
HFQQQQRY
ND
YL
DNQ
R
FR
A
MNDLS
WGF
T
E
LTL
N
N
ELL
AQ
GKIMID
S
A
S
G
TL
PDGTVFS
I
P
DQ
D
A
LP
D
P
-
LH
P
QH
F
P
D
ER
S
RN
IYLALPV
A
S
D
V
R
NEI
-
---
S
DG
RR
IG
RY
--
R
LNYAD
VRD
L
H
SE
EGD
TRT
L
T
LG
Q
L
T
PRI
M
S
--
GAED
MS
AYITLPL
C
RI
SD
RHA
D
GSLT
L
DD
D
FIP
SC
QN
IQ
VS
KK
L
RVY
L
K
EVQ
GA
I
GG
RA
S
DLA
N
--
RI
G
S
PAQ
SG
--
IADVAEFMMLQ
L
LNR
N
Q
TR
FTH
HA
R
RSQ
LHPE
DF
Y
L
DLA
G
LLGELMTF
T
E
P
-
S
RLPC
P
L
D
-------
V
Y
D
H
H
DL
TK
TF
-
K
TL
L
PEV
K
RAL
H
TVL
S
PRA
V
NL
P
L
HLRD
G
I
-
W
---
Q
A
D
IHD
TE
LLQ
S
A
T
FVLAVAA
N
-
MP
V
DQIQ
R
QFIQQSKI
S
SPEKI
RN
MVSVQIPGI
P
L
RA
LM
V
APRQLP
Y
H
S
G
FS
YFELDK
SGQ
AW
TE
M
AA
AG
AV
ALH
V
SGSFPDLN
M
QLWAIRG
fig|585055.8.peg.227
Escherichia coli 55989
MATTRNKVMW
Q
EG
M
L
MR
P
H
HFQQQQRY
ND
YL
DNQ
R
FR
A
MNDLS
WGF
T
E
LTL
N
N
ELL
AQ
GKIMID
S
A
S
G
TL
PDGTVFS
I
P
DQ
D
A
LP
D
P
-
LH
P
QH
F
P
D
ER
S
RN
IYLALPV
A
S
D
V
R
NEI
-
---
S
DG
RR
IG
RY
--
R
LNYAD
VRD
L
H
SE
EGD
TRT
L
T
LG
Q
L
T
PRI
M
S
--
GAED
MS
AYITLPL
C
RI
SD
RHA
D
GSLT
L
DD
D
FIP
SC
QN
IQ
VS
KK
L
RVY
L
K
EVQ
GA
I
GG
RA
S
DLA
N
--
RI
G
S
PAQ
SG
--
IADVAEFMMLQ
L
LNR
N
Q
TR
FTH
HA
R
RSQ
LHPE
DF
Y
L
DLA
G
LLGELMTF
T
E
P
-
S
RLPC
P
L
D
-------
V
Y
D
H
H
DL
TK
TF
-
K
TL
L
PEV
K
RAL
H
TVL
S
PRA
V
NL
P
L
HLRD
G
I
-
W
---
Q
A
D
IHD
TE
LLQ
S
A
T
FVLAVAA
N
-
MP
V
DQIQ
R
QFIQQSKI
S
SPEKI
RN
MVSVQIPGI
P
L
RA
LM
V
APRQLP
Y
H
S
G
FS
YFELDK
SGQ
AW
TE
M
AA
AG
AV
ALH
V
SGSFPDLN
M
QLWAIRG
fig|331111.12.peg.558
Escherichia coli E24377A
MATTRNKVMW
Q
EG
M
L
MR
P
H
HFQQQQRY
ND
YL
DNQ
R
FR
A
MNDLS
WGF
T
E
LTL
N
N
ELL
AQ
GKIMID
S
A
S
G
TL
PDGTVFS
I
P
DQ
D
A
LP
D
P
-
LH
P
QH
F
P
D
ER
S
RN
IYLALPV
A
S
D
V
R
NEI
-
---
S
DG
RR
IG
RY
--
R
LNYAD
VRD
L
H
SE
EGD
TRT
L
T
LG
Q
L
T
PRI
M
S
--
GAED
MS
AYITLPL
C
RI
SD
RHA
D
GSLT
L
DD
D
FIP
SC
QN
IQ
VS
KK
L
RVY
L
K
EVQ
GA
I
GG
RA
S
DLA
N
--
RI
G
S
PAQ
SG
--
IADVAEFMMLQ
L
LNR
N
Q
TR
FTH
HA
R
RSQ
LHPE
DF
Y
L
DLA
G
LLGELMTF
T
E
P
-
S
RLPC
P
L
D
-------
V
Y
D
H
H
DL
TK
TF
-
K
TL
L
PEV
K
RAL
H
TVL
S
PRA
V
NL
P
L
HLRD
G
I
-
W
---
Q
A
D
IHD
TE
LLQ
S
A
T
FVLAVAA
N
-
MP
V
DQIQ
R
QFIQQSKI
S
SPEKI
RN
MVSVQIPGI
P
L
RA
LM
V
APRQLP
Y
H
S
G
FS
YFELDK
SGQ
AW
TE
M
AA
AG
AV
ALH
V
SGSFPDLN
M
QLWAIRG
fig|331111.3.peg.2794
Escherichia coli E24377A
MATTRNKVMW
Q
EG
M
L
MR
P
H
HFQQQQRY
ND
YL
DNQ
R
FR
A
MNDLS
WGF
T
E
LTL
N
N
ELL
AQ
GKIMID
S
A
S
G
TL
PDGTVFS
I
P
DQ
D
A
LP
D
P
-
LH
P
QH
F
P
D
ER
S
RN
IYLALPV
A
S
D
V
R
NEI
-
---
S
DG
RR
IG
RY
--
R
LNYAD
VRD
L
H
SE
EGD
TRT
L
T
LG
Q
L
T
PRI
M
S
--
GAED
MS
AYITLPL
C
RI
SD
RHA
D
GSLT
L
DD
D
FIP
SC
QN
IQ
VS
KK
L
RVY
L
K
EVQ
GA
I
GG
RA
S
DLA
N
--
RI
G
S
PAQ
SG
--
IADVAEFMMLQ
L
LNR
N
Q
TR
FTH
HA
R
RSQ
LHPE
DF
Y
L
DLA
G
LLGELMTF
T
E
P
-
S
RLPC
P
L
D
-------
V
Y
D
H
H
DL
TK
TF
-
K
TL
L
PEV
K
RAL
H
TVL
S
PRA
V
NL
P
L
HLRD
G
I
-
W
---
Q
A
D
IHD
TE
LLQ
S
A
T
FVLAVAA
N
-
MP
V
DQIQ
R
QFIQQSKI
S
SPEKI
RN
MVSVQIPGI
P
L
RA
LM
V
APRQLP
Y
H
S
G
FS
YFELDK
SGQ
AW
TE
M
AA
AG
AV
ALH
V
SGSFPDLN
M
QLWAIRG
fig|562.375.peg.5258
Escherichia coli EC4100B
MATTRNKVMW
Q
EG
M
L
MR
P
H
HFQQQQRY
ND
YL
DNQ
R
FR
A
MNDLS
WGF
T
E
LTL
N
N
ELL
AQ
GKIMID
S
A
S
G
TL
PDGTVFS
I
P
DQ
D
A
LP
D
P
-
LH
P
QH
F
P
D
ER
S
RN
IYLALPV
A
S
D
V
R
NEI
-
---
S
DG
RR
IG
RY
--
R
LNYAD
VRD
L
H
SE
EGD
TRT
L
T
LG
Q
L
T
PRI
M
S
--
GAED
MS
AYITLPL
C
RI
SD
RHA
D
GSLT
L
DD
D
FIP
SC
QN
IQ
VS
KK
L
RVY
L
K
EVQ
GA
I
GG
RA
S
DLA
N
--
RI
G
S
PAQ
SG
--
IADVAEFMMLQ
L
LNR
N
Q
TR
FTH
HA
R
RSQ
LHPE
DF
Y
L
DLA
G
LLGELMTF
T
E
P
-
S
RLPC
P
L
D
-------
V
Y
D
H
H
DL
TK
TF
-
K
TL
L
PEV
K
RAL
H
TVL
S
PRA
V
NL
P
L
HLRD
G
I
-
W
---
Q
A
D
IHD
TE
LLQ
S
A
T
FVLAVAA
N
-
MP
V
DQIQ
R
QFIQQSKI
S
SPEKI
RN
MVSVQIPGI
P
L
RA
LM
V
APRQLP
Y
H
S
G
FS
YFELDK
SGQ
AW
TE
M
AA
AG
AV
ALH
V
SGSFPDLN
M
QLWAIRG
fig|331112.3.peg.222
Escherichia coli HS
MATTRNKVMW
Q
EG
M
L
MR
P
H
HFQQQQRY
ND
YL
DNQ
R
FR
A
MNNLS
WGF
T
E
LTL
N
N
ELL
AQ
GKIMID
S
A
S
G
TL
PDGTVFS
I
P
DQ
D
A
LP
D
P
-
LH
P
QH
F
P
D
ER
S
RN
IYLALPV
A
S
D
V
R
NEI
-
---
S
DG
RR
IG
RY
--
R
LNYAD
VRD
L
H
SE
EGD
TRT
L
T
LG
Q
L
T
PRI
M
S
--
GAED
MS
AYITLPL
C
RI
SD
RHA
D
GSLT
L
DD
D
FIP
SC
QN
IQ
VS
KK
L
RVY
L
K
EVQ
GA
I
GG
RA
S
DLA
N
--
RI
G
S
PAQ
SG
--
IADVAEFMMLQ
L
LNR
N
Q
TR
FTH
RA
R
RSQ
LHPE
DF
Y
L
DLA
G
LLGELMTF
T
E
P
-
S
RLPC
P
L
D
-------
V
Y
D
H
H
DL
TK
TF
-
K
TL
L
PEV
K
RAL
H
TVL
S
PRA
V
NL
P
L
HLRD
G
I
-
W
---
Q
A
D
IHD
TE
LLQ
S
A
T
FVLAVAA
N
-
MP
V
DQIQ
R
QFIQQSKI
S
SPEKI
RN
MVSVQIPGI
P
L
RA
LM
V
APRQLP
Y
H
S
G
FS
YFELDK
SGQ
AW
TE
M
AA
AG
AV
ALH
V
SGSFPDLN
M
QLWAIRG
fig|331112.6.peg.227
Escherichia coli HS
MATTRNKVMW
Q
EG
M
L
MR
P
H
HFQQQQRY
ND
YL
DNQ
R
FR
A
MNNLS
WGF
T
E
LTL
N
N
ELL
AQ
GKIMID
S
A
S
G
TL
PDGTVFS
I
P
DQ
D
A
LP
D
P
-
LH
P
QH
F
P
D
ER
S
RN
IYLALPV
A
S
D
V
R
NEI
-
---
S
DG
RR
IG
RY
--
R
LNYAD
VRD
L
H
SE
EGD
TRT
L
T
LG
Q
L
T
PRI
M
S
--
GAED
MS
AYITLPL
C
RI
SD
RHA
D
GSLT
L
DD
D
FIP
SC
QN
IQ
VS
KK
L
RVY
L
K
EVQ
GA
I
GG
RA
S
DLA
N
--
RI
G
S
PAQ
SG
--
IADVAEFMMLQ
L
LNR
N
Q
TR
FTH
RA
R
RSQ
LHPE
DF
Y
L
DLA
G
LLGELMTF
T
E
P
-
S
RLPC
P
L
D
-------
V
Y
D
H
H
DL
TK
TF
-
K
TL
L
PEV
K
RAL
H
TVL
S
PRA
V
NL
P
L
HLRD
G
I
-
W
---
Q
A
D
IHD
TE
LLQ
S
A
T
FVLAVAA
N
-
MP
V
DQIQ
R
QFIQQSKI
S
SPEKI
RN
MVSVQIPGI
P
L
RA
LM
V
APRQLP
Y
H
S
G
FS
YFELDK
SGQ
AW
TE
M
AA
AG
AV
ALH
V
SGSFPDLN
M
QLWAIRG
fig|595495.4.peg.4430
Escherichia coli KO11
MATTRNKVMW
Q
EG
M
L
MR
P
H
HFQQQQRY
ND
YL
DNQ
R
FR
A
MNNLS
WGF
T
E
LTL
N
N
ELL
AQ
GKIMID
S
A
S
G
TL
PDGTVFS
I
P
DQ
D
A
LP
D
P
-
LH
P
QH
F
P
D
ER
S
RN
IYLALPV
A
S
D
V
R
NEI
-
---
S
DG
RR
IG
RY
--
R
LNYAD
VRD
L
H
SE
EGD
TRT
L
T
LG
Q
L
T
PRI
M
S
--
GAED
MS
AYITLPL
C
RI
SD
RHA
D
GSLT
L
DD
D
FIP
SC
QN
IQ
VS
KK
L
RVY
L
K
EVQ
GA
I
GG
RA
S
DLA
N
--
RI
G
S
PAQ
SG
--
IADVAEFMMLQ
L
LNR
N
Q
TR
FTH
RA
R
RSQ
LHPE
DF
Y
L
DLA
G
LLGELMTF
T
E
P
-
S
RLPC
P
L
D
-------
V
Y
D
H
H
DL
TK
TF
-
K
TL
L
PEV
K
RAL
H
TVL
S
PRA
V
NL
P
L
HLRD
G
I
-
W
---
Q
A
D
IHD
TE
LLQ
S
A
T
FVLAVAA
N
-
MP
V
DQIQ
R
QFIQQSKI
S
SPEKI
RN
MVSVQIPGI
P
L
RA
LM
V
APRQLP
Y
H
S
G
FS
YFELDK
SGQ
AW
TE
M
AA
AG
AV
ALH
V
SGSFPDLN
M
QLWAIRG
fig|566546.3.peg.4465
Escherichia coli W
MATTRNKVMW
Q
EG
M
L
MR
P
H
HFQQQQRY
ND
YL
DNQ
R
FR
A
MNNLS
WGF
T
E
LTL
N
N
ELL
AQ
GKIMID
S
A
S
G
TL
PDGTVFS
I
P
DQ
D
A
LP
D
P
-
LH
P
QH
F
P
D
ER
S
RN
IYLALPV
A
S
D
V
R
NEI
-
---
S
DG
RR
IG
RY
--
R
LNYAD
VRD
L
H
SE
EGD
TRT
L
T
LG
Q
L
T
PRI
M
S
--
GAED
MS
AYITLPL
C
RI
SD
RHA
D
GSLT
L
DD
D
FIP
SC
QN
IQ
VS
KK
L
RVY
L
K
EVQ
GA
I
GG
RA
S
DLA
N
--
RI
G
S
PAQ
SG
--
IADVAEFMMLQ
L
LNR
N
Q
TR
FTH
RA
R
RSQ
LHPE
DF
Y
L
DLA
G
LLGELMTF
T
E
P
-
S
RLPC
P
L
D
-------
V
Y
D
H
H
DL
TK
TF
-
K
TL
L
PEV
K
RAL
H
TVL
S
PRA
V
NL
P
L
HLRD
G
I
-
W
---
Q
A
D
IHD
TE
LLQ
S
A
T
FVLAVAA
N
-
MP
V
DQIQ
R
QFIQQSKI
S
SPEKI
RN
MVSVQIPGI
P
L
RA
LM
V
APRQLP
Y
H
S
G
FS
YFELDK
SGQ
AW
TE
M
AA
AG
AV
ALH
V
SGSFPDLN
M
QLWAIRG
fig|566546.4.peg.221
Escherichia coli W
MATTRNKVMW
Q
EG
M
L
MR
P
H
HFQQQQRY
ND
YL
DNQ
R
FR
A
MNNLS
WGF
T
E
LTL
N
N
ELL
AQ
GKIMID
S
A
S
G
TL
PDGTVFS
I
P
DQ
D
A
LP
D
P
-
LH
P
QH
F
P
D
ER
S
RN
IYLALPV
A
S
D
V
R
NEI
-
---
S
DG
RR
IG
RY
--
R
LNYAD
VRD
L
H
SE
EGD
TRT
L
T
LG
Q
L
T
PRI
M
S
--
GAED
MS
AYITLPL
C
RI
SD
RHA
D
GSLT
L
DD
D
FIP
SC
QN
IQ
VS
KK
L
RVY
L
K
EVQ
GA
I
GG
RA
S
DLA
N
--
RI
G
S
PAQ
SG
--
IADVAEFMMLQ
L
LNR
N
Q
TR
FTH
RA
R
RSQ
LHPE
DF
Y
L
DLA
G
LLGELMTF
T
E
P
-
S
RLPC
P
L
D
-------
V
Y
D
H
H
DL
TK
TF
-
K
TL
L
PEV
K
RAL
H
TVL
S
PRA
V
NL
P
L
HLRD
G
I
-
W
---
Q
A
D
IHD
TE
LLQ
S
A
T
FVLAVAA
N
-
MP
V
DQIQ
R
QFIQQSKI
S
SPEKI
RN
MVSVQIPGI
P
L
RA
LM
V
APRQLP
Y
H
S
G
FS
YFELDK
SGQ
AW
TE
M
AA
AG
AV
ALH
V
SGSFPDLN
M
QLWAIRG
fig|749531.3.peg.4583
Escherichia coli MS 69-1
MATTRNKVMW
Q
EG
M
L
MR
P
H
HFQQQQRY
ND
YL
DNQ
R
FR
A
MNDLS
WGF
T
E
LTL
N
N
ELL
AQ
GKIMID
S
A
S
G
TL
PDGTVFS
I
P
DQ
D
A
LP
D
P
-
LH
P
QH
F
P
D
ER
S
RN
IYLALPV
A
S
D
V
R
NEI
-
---
S
DG
RR
IG
RY
--
R
LNYAD
VRD
L
H
SE
EGD
ART
L
T
LG
Q
L
T
PRI
M
S
--
GAED
MS
AYITLPL
C
RI
SD
RHA
D
GSLT
L
DD
D
FIP
SC
QN
IQ
VS
KK
L
RVY
L
K
EVQ
GA
I
GG
RA
S
DLA
N
--
RI
G
S
PAQ
SG
--
IADVAEFMMLQ
L
LNR
N
Q
TR
FTH
RA
R
RSQ
LHPE
DF
Y
L
DLA
G
LLGELMTF
T
E
P
-
S
RLPC
P
L
D
-------
V
Y
D
H
H
DL
TK
TF
-
K
TL
L
PEV
K
RAL
H
TVL
S
PRA
V
NL
P
L
HLRD
G
I
-
W
---
Q
A
D
IHD
TE
LLQ
S
A
T
FVLAVAA
N
-
MP
V
DQIQ
R
QFIQQSKI
S
SPEKI
RN
MVSVQIPGI
P
L
RA
LM
V
APRQLP
Y
H
S
G
FS
YFELDK
SGQ
AW
TE
M
AA
AG
AV
ALH
V
SGSFPDLN
M
QLWAIRG
fig|585396.4.peg.231
Escherichia coli O111:H- str. 11128
MATTRNKVMW
Q
EG
M
L
MR
P
H
HFQQQQRY
ND
YL
DNQ
R
FR
A
MNDLS
WGF
T
E
LTL
N
N
ELL
AQ
GKIMID
S
A
S
G
TL
PDGTVFS
I
P
DQ
D
A
LP
D
P
-
LH
P
QH
F
P
D
ER
S
RN
IYL
T
LPV
A
S
D
V
R
NEI
-
---
S
DG
RR
IG
RY
--
R
LNYAD
VRD
L
H
SE
EGD
TRT
L
T
LG
Q
L
T
PRI
M
S
--
GAED
MS
AYITLPL
C
RI
SD
RHA
D
GSLT
L
DD
D
FIP
SC
QN
IQ
VS
KK
L
RVY
L
K
EVQ
GA
I
GG
RA
S
DLA
N
--
RI
G
S
PAQ
SG
--
IADVAEFMMLQ
L
LNR
N
Q
TR
FTH
RA
R
RSQ
LHPE
DF
Y
L
DLA
G
LLGELMTF
T
E
P
-
S
RLPC
P
L
D
-------
V
Y
D
H
H
DL
TK
TF
-
K
TL
L
PEV
K
RAL
H
TVL
S
PRA
V
NL
P
L
HLRD
G
I
-
W
---
Q
A
D
IHD
TE
LLQ
S
A
T
FVLAVAA
N
-
V
P
V
DQIQ
R
QFIQQSKI
S
SPEKI
RN
MVSVQIPGI
P
L
RA
LM
V
APRQLP
Y
H
S
G
FS
YFELDK
SGQ
AW
TE
M
AA
AG
AV
ALH
V
SGSFPDLN
M
QLWAIRG
fig|670888.3.peg.810
Escherichia coli 1827-70
MATTRNKVMW
Q
EG
M
L
MR
P
H
HFQQQQRY
ND
YL
DNQ
R
FR
A
MNDLS
WGF
T
E
LTL
N
N
ELL
AQ
GKIMID
S
A
S
G
TL
PDGTVFS
I
P
DQ
D
A
LP
D
P
-
LH
P
QH
F
P
D
ER
S
RN
IYLALPV
A
S
D
V
R
NEI
-
---
S
DG
RR
IG
RY
--
R
LNYAD
VRD
L
H
SE
EGD
TRT
L
T
LG
Q
L
T
PRI
M
S
--
GAED
MS
AYITLPL
C
RI
SN
RHA
D
GSLT
L
DD
D
FIP
SC
QN
IQ
VS
KK
L
RVY
L
K
EVQ
GA
I
GG
RA
S
DLA
N
--
RI
G
S
PAQ
SG
--
IADVAEFMMLQ
L
LNR
N
Q
TR
FTH
RA
R
RSQ
LHPE
DF
Y
L
DLA
G
LLGELMTF
T
E
P
-
S
RLPC
P
L
D
-------
V
Y
D
H
H
DL
TK
TF
-
K
TL
L
PEV
K
RAL
H
TVL
S
PRA
V
NL
P
L
HLRD
G
I
-
W
---
Q
A
D
IHD
TE
LLQ
S
A
T
FVLAVAA
N
-
V
P
V
DQIQ
R
QFIQQSKI
S
SPEKI
RN
MVSVQIPGI
P
L
RA
LM
V
APRQLP
Y
H
S
G
FS
YFELDK
SGQ
AW
TE
M
AA
AG
AV
ALH
V
SGSFPDLN
M
QLWAIRG
fig|656408.3.peg.145
Escherichia coli H591
MATTRNKVMW
Q
EG
M
L
MR
P
H
HFQQQQRY
ND
YL
DNQ
R
FR
A
MNDLS
WGF
T
E
LTL
N
N
ELL
AQ
GKIMID
S
A
S
G
TL
PDGTVFS
I
P
DQ
D
A
LP
D
P
-
LH
P
QH
F
P
D
ER
S
RN
IYLALPV
A
S
D
V
R
NEI
-
---
S
DG
RR
IG
RY
--
R
LNYAD
VRD
L
H
SE
EGD
ART
L
T
LG
Q
L
T
PRI
M
S
--
GAED
MS
AYITLPL
C
RI
SD
RHA
D
GSLT
L
DD
D
FIP
SC
QN
IQ
VS
KK
L
RVY
L
K
EVQ
GA
I
GG
RA
S
DLA
N
--
RI
G
S
PAQ
SG
--
IADVAEFMMLQ
L
LNR
N
Q
TR
FTH
RA
R
RSQ
LHPE
DF
Y
L
DLA
G
LLGELMTF
T
E
L
-
S
RLPC
P
L
D
-------
V
Y
D
H
H
DL
TK
TF
-
K
TL
L
PEV
K
RAL
H
TVL
S
PRA
V
NL
P
L
HLRD
G
I
-
W
---
Q
A
D
IHD
TE
LLQ
S
A
T
FVLAVAA
N
-
MP
V
DQIQ
R
QFIQQSKI
S
SPEKI
RN
MVSVQIPGI
P
L
RA
LM
V
APRQLP
Y
H
S
G
FS
YFELDK
SGQ
AW
TE
M
AA
AG
AV
ALH
V
SGSFPDLN
M
QLWAIRG
fig|679206.4.peg.3186
Escherichia coli MS 119-7
MATTRNKVMW
Q
EG
M
L
MR
P
H
HFQQQQRY
ND
YL
DNQ
R
FR
A
MNDLS
WGF
T
E
LTL
N
N
ELL
AQ
GKIMID
S
A
S
G
TL
PDGTVFS
I
P
DQ
D
A
LP
D
P
-
LH
P
QH
F
P
D
ER
S
RN
IYLALPV
A
S
D
V
R
NEI
-
---
S
DG
RR
IG
RY
--
R
LNYAD
VRD
L
H
SE
EGD
ART
L
T
LG
Q
L
T
PRI
M
S
--
GAED
MS
AYITLPL
C
RI
SD
RHA
D
GSLT
L
DD
D
FIP
SC
QN
IQ
VS
KK
L
RVY
L
K
EVQ
GA
I
GG
RA
S
DLA
N
--
RI
G
S
PAQ
SG
--
IADVAEFMMLQ
L
LNR
N
Q
TR
FTH
RA
R
RSQ
LHPE
DF
Y
L
DLA
G
LLGELMTF
T
E
L
-
S
RLPC
P
L
D
-------
V
Y
D
H
H
DL
TK
TF
-
K
TL
L
PEV
K
RAL
H
TVL
S
PRA
V
NL
P
L
HLRD
G
I
-
W
---
Q
A
D
IHD
TE
LLQ
S
A
T
FVLAVAA
N
-
MP
V
DQIQ
R
QFIQQSKI
S
SPEKI
RN
MVSVQIPGI
P
L
RA
LM
V
APRQLP
Y
H
S
G
FS
YFELDK
SGQ
AW
TE
M
AA
AG
AV
ALH
V
SGSFPDLN
M
QLWAIRG
fig|656443.3.peg.373
Escherichia coli TA271
MATTRNKVMW
Q
EG
M
L
MR
P
H
HFQQQQRY
ND
YL
DNQ
R
FR
A
MNDLS
WGF
T
E
LTL
N
N
ELL
AQ
GKIMID
S
A
S
G
TL
PDGTVFS
I
P
DQ
D
A
LP
D
P
-
LH
P
QH
F
P
D
ER
S
RN
IYLALPV
A
S
D
V
R
NEI
-
---
S
DG
RR
IG
RY
--
R
LNYAD
VRD
L
H
SE
EGD
ART
L
T
LG
Q
L
T
PRI
M
S
--
GAED
MS
AYITLPL
C
RI
SD
RHA
D
GSLT
L
DD
D
FIP
SC
QN
IQ
VS
KK
L
RVY
L
K
EVQ
GA
I
GG
RA
S
DLA
N
--
RI
G
S
PAQ
SG
--
IADVAEFMMLQ
L
LNR
N
Q
TR
FTH
RA
R
RSQ
LHPE
DF
Y
L
DLA
G
LLGELMTF
T
E
L
-
S
RLPC
P
L
D
-------
V
Y
D
H
H
DL
TK
TF
-
K
TL
L
PEV
K
RAL
H
TVL
S
PRA
V
NL
P
L
HLRD
G
I
-
W
---
Q
A
D
IHD
TE
LLQ
S
A
T
FVLAVAA
N
-
MP
V
DQIQ
R
QFIQQSKI
S
SPEKI
RN
MVSVQIPGI
P
L
RA
LM
V
APRQLP
Y
H
S
G
FS
YFELDK
SGQ
AW
TE
M
AA
AG
AV
ALH
V
SGSFPDLN
M
QLWAIRG
fig|550672.3.peg.20
Escherichia coli B088
MATTRNKVMW
Q
EG
M
L
MR
P
H
HFQQQQRY
ND
YL
DNQ
R
FR
A
MNDLS
WGF
T
E
LTL
N
N
ELL
AQ
GKIMID
S
A
S
G
TL
PDGTVFS
I
P
DQ
D
A
LP
D
P
-
LH
P
QN
F
P
D
ER
S
RN
IYLALPV
A
S
D
V
R
NEI
-
---
S
DG
RR
IG
RY
--
R
LNYAD
VRD
L
H
SE
EGD
ART
L
T
LG
Q
L
T
PRI
M
S
--
GAED
MS
AYITLPL
C
RI
SD
RHA
D
GSLT
L
DD
D
FIP
SC
QN
IQ
VS
KK
L
RVY
L
K
EVQ
GA
I
GG
RA
S
DLA
N
--
RI
G
S
PAQ
SG
--
IADVAEFMMLQ
L
LNR
N
Q
TR
FTH
RA
R
RSQ
LHPE
DF
Y
L
DLA
G
LLGELMTF
T
E
P
-
S
RLPC
P
L
D
-------
V
Y
D
H
H
DL
TK
TF
-
K
TL
L
PEV
K
RAL
H
TVL
S
PRA
V
NL
P
L
HLRD
G
I
-
W
---
Q
A
D
IHD
TE
LLQ
S
A
T
FVLAVAA
N
-
V
P
V
DQIQ
R
QFIQQSKI
S
SPEKI
RN
MVSVQIPGI
P
L
RA
LM
V
APRQLP
Y
H
S
G
FS
YFELDK
SGQ
AW
TE
M
AA
AG
AV
ALH
V
SGSFPDLN
M
QLWAIRG
fig|344601.3.peg.1947
Escherichia coli B171
MATTRNKVMW
Q
EG
M
L
MR
P
H
HFQQQQRY
ND
YL
DNQ
R
FR
A
MNDLS
WGF
T
E
LTL
N
N
ELL
AQ
GKIMID
S
A
S
G
TL
PDGTVFS
I
P
DQ
D
A
LP
D
P
-
LH
P
QN
F
P
D
ER
S
RN
IYLALPV
A
S
D
V
R
NEI
-
---
S
DG
RR
IG
RY
--
R
LNYAD
VRD
L
H
SE
EGD
ART
L
T
LG
Q
L
T
PRI
M
S
--
GAED
MS
AYITLPL
C
RI
SD
RHA
D
GSLT
L
DD
D
FIP
SC
QN
IQ
VS
KK
L
RVY
L
K
EVQ
GA
I
GG
RA
S
DLA
N
--
RI
G
S
PAQ
SG
--
IADVAEFMMLQ
L
LNR
N
Q
TR
FTH
RA
R
RSQ
LHPE
DF
Y
L
DLA
G
LLGELMTF
T
E
P
-
S
RLPC
P
L
D
-------
V
Y
D
H
H
DL
TK
TF
-
K
TL
L
PEV
K
RAL
H
TVL
S
PRA
V
NL
P
L
HLRD
G
I
-
W
---
Q
A
D
IHD
TE
LLQ
S
A
T
FVLAVAA
N
-
V
P
V
DQIQ
R
QFIQQSKI
S
SPEKI
RN
MVSVQIPGI
P
L
RA
LM
V
APRQLP
Y
H
S
G
FS
YFELDK
SGQ
AW
TE
M
AA
AG
AV
ALH
V
SGSFPDLN
M
QLWAIRG
fig|344601.5.peg.2029
Escherichia coli B171
MATTRNKVMW
Q
EG
M
L
MR
P
H
HFQQQQRY
ND
YL
DNQ
R
FR
A
MNDLS
WGF
T
E
LTL
N
N
ELL
AQ
GKIMID
S
A
S
G
TL
PDGTVFS
I
P
DQ
D
A
LP
D
P
-
LH
P
QN
F
P
D
ER
S
RN
IYLALPV
A
S
D
V
R
NEI
-
---
S
DG
RR
IG
RY
--
R
LNYAD
VRD
L
H
SE
EGD
ART
L
T
LG
Q
L
T
PRI
M
S
--
GAED
MS
AYITLPL
C
RI
SD
RHA
D
GSLT
L
DD
D
FIP
SC
QN
IQ
VS
KK
L
RVY
L
K
EVQ
GA
I
GG
RA
S
DLA
N
--
RI
G
S
PAQ
SG
--
IADVAEFMMLQ
L
LNR
N
Q
TR
FTH
RA
R
RSQ
LHPE
DF
Y
L
DLA
G
LLGELMTF
T
E
P
-
S
RLPC
P
L
D
-------
V
Y
D
H
H
DL
TK
TF
-
K
TL
L
PEV
K
RAL
H
TVL
S
PRA
V
NL
P
L
HLRD
G
I
-
W
---
Q
A
D
IHD
TE
LLQ
S
A
T
FVLAVAA
N
-
V
P
V
DQIQ
R
QFIQQSKI
S
SPEKI
RN
MVSVQIPGI
P
L
RA
LM
V
APRQLP
Y
H
S
G
FS
YFELDK
SGQ
AW
TE
M
AA
AG
AV
ALH
V
SGSFPDLN
M
QLWAIRG
fig|340184.3.peg.2096
Escherichia coli B7A
MATTRNKVMW
Q
EG
M
L
MR
P
H
HFQQQQRY
ND
YL
DNQ
R
FR
A
MNDLS
WGF
T
E
LTL
N
N
ELL
AQ
GKIMID
S
A
S
G
TL
PDGTVFS
I
P
DQ
D
A
LP
D
P
-
LH
P
QN
F
P
D
ER
S
RN
IYLALPV
A
S
D
V
R
NEI
-
---
S
DG
RR
IG
RY
--
R
LNYAD
VRD
L
H
SE
EGD
ART
L
T
LG
Q
L
T
PRI
M
S
--
GAED
MS
AYITLPL
C
RI
SD
RHA
D
GSLT
L
DD
D
FIP
SC
QN
IQ
VS
KK
L
RVY
L
K
EVQ
GA
I
GG
RA
S
DLA
N
--
RI
G
S
PAQ
SG
--
IADVAEFMMLQ
L
LNR
N
Q
TR
FTH
RA
R
RSQ
LHPE
DF
Y
L
DLA
G
LLGELMTF
T
E
P
-
S
RLPC
P
L
D
-------
V
Y
D
H
H
DL
TK
TF
-
K
TL
L
PEV
K
RAL
H
TVL
S
PRA
V
NL
P
L
HLRD
G
I
-
W
---
Q
A
D
IHD
TE
LLQ
S
A
T
FVLAVAA
N
-
V
P
V
DQIQ
R
QFIQQSKI
S
SPEKI
RN
MVSVQIPGI
P
L
RA
LM
V
APRQLP
Y
H
S
G
FS
YFELDK
SGQ
AW
TE
M
AA
AG
AV
ALH
V
SGSFPDLN
M
QLWAIRG
fig|340184.6.peg.2202
Escherichia coli B7A
MATTRNKVMW
Q
EG
M
L
MR
P
H
HFQQQQRY
ND
YL
DNQ
R
FR
A
MNDLS
WGF
T
E
LTL
N
N
ELL
AQ
GKIMID
S
A
S
G
TL
PDGTVFS
I
P
DQ
D
A
LP
D
P
-
LH
P
QN
F
P
D
ER
S
RN
IYLALPV
A
S
D
V
R
NEI
-
---
S
DG
RR
IG
RY
--
R
LNYAD
VRD
L
H
SE
EGD
ART
L
T
LG
Q
L
T
PRI
M
S
--
GAED
MS
AYITLPL
C
RI
SD
RHA
D
GSLT
L
DD
D
FIP
SC
QN
IQ
VS
KK
L
RVY
L
K
EVQ
GA
I
GG
RA
S
DLA
N
--
RI
G
S
PAQ
SG
--
IADVAEFMMLQ
L
LNR
N
Q
TR
FTH
RA
R
RSQ
LHPE
DF
Y
L
DLA
G
LLGELMTF
T
E
P
-
S
RLPC
P
L
D
-------
V
Y
D
H
H
DL
TK
TF
-
K
TL
L
PEV
K
RAL
H
TVL
S
PRA
V
NL
P
L
HLRD
G
I
-
W
---
Q
A
D
IHD
TE
LLQ
S
A
T
FVLAVAA
N
-
V
P
V
DQIQ
R
QFIQQSKI
S
SPEKI
RN
MVSVQIPGI
P
L
RA
LM
V
APRQLP
Y
H
S
G
FS
YFELDK
SGQ
AW
TE
M
AA
AG
AV
ALH
V
SGSFPDLN
M
QLWAIRG
fig|340186.3.peg.741
Escherichia coli E110019
MATTRNKVMW
Q
EG
M
L
MR
P
H
HFQQQQRY
ND
YL
DNQ
R
FR
A
MNDLS
WGF
T
E
LTL
N
N
ELL
AQ
GKIMID
S
A
S
G
TL
PDGTVFS
I
P
DQ
D
A
LP
D
P
-
LH
P
QN
F
P
D
ER
S
RN
IYLALPV
A
S
D
V
R
NEI
-
---
S
DG
RR
IG
RY
--
R
LNYAD
VRD
L
H
SE
EGD
ART
L
T
LG
Q
L
T
PRI
M
S
--
GAED
MS
AYITLPL
C
RI
SD
RHA
D
GSLT
L
DD
D
FIP
SC
QN
IQ
VS
KK
L
RVY
L
K
EVQ
GA
I
GG
RA
S
DLA
N
--
RI
G
S
PAQ
SG
--
IADVAEFMMLQ
L
LNR
N
Q
TR
FTH
RA
R
RSQ
LHPE
DF
Y
L
DLA
G
LLGELMTF
T
E
P
-
S
RLPC
P
L
D
-------
V
Y
D
H
H
DL
TK
TF
-
K
TL
L
PEV
K
RAL
H
TVL
S
PRA
V
NL
P
L
HLRD
G
I
-
W
---
Q
A
D
IHD
TE
LLQ
S
A
T
FVLAVAA
N
-
V
P
V
DQIQ
R
QFIQQSKI
S
SPEKI
RN
MVSVQIPGI
P
L
RA
LM
V
APRQLP
Y
H
S
G
FS
YFELDK
SGQ
AW
TE
M
AA
AG
AV
ALH
V
SGSFPDLN
M
QLWAIRG
fig|340186.5.peg.768
Escherichia coli E110019
MATTRNKVMW
Q
EG
M
L
MR
P
H
HFQQQQRY
ND
YL
DNQ
R
FR
A
MNDLS
WGF
T
E
LTL
N
N
ELL
AQ
GKIMID
S
A
S
G
TL
PDGTVFS
I
P
DQ
D
A
LP
D
P
-
LH
P
QN
F
P
D
ER
S
RN
IYLALPV
A
S
D
V
R
NEI
-
---
S
DG
RR
IG
RY
--
R
LNYAD
VRD
L
H
SE
EGD
ART
L
T
LG
Q
L
T
PRI
M
S
--
GAED
MS
AYITLPL
C
RI
SD
RHA
D
GSLT
L
DD
D
FIP
SC
QN
IQ
VS
KK
L
RVY
L
K
EVQ
GA
I
GG
RA
S
DLA
N
--
RI
G
S
PAQ
SG
--
IADVAEFMMLQ
L
LNR
N
Q
TR
FTH
RA
R
RSQ
LHPE
DF
Y
L
DLA
G
LLGELMTF
T
E
P
-
S
RLPC
P
L
D
-------
V
Y
D
H
H
DL
TK
TF
-
K
TL
L
PEV
K
RAL
H
TVL
S
PRA
V
NL
P
L
HLRD
G
I
-
W
---
Q
A
D
IHD
TE
LLQ
S
A
T
FVLAVAA
N
-
V
P
V
DQIQ
R
QFIQQSKI
S
SPEKI
RN
MVSVQIPGI
P
L
RA
LM
V
APRQLP
Y
H
S
G
FS
YFELDK
SGQ
AW
TE
M
AA
AG
AV
ALH
V
SGSFPDLN
M
QLWAIRG
fig|340185.3.peg.1530
Escherichia coli E22
MATTRNKVMW
Q
EG
M
L
MR
P
H
HFQQQQRY
ND
YL
DNQ
R
FR
A
MNDLS
WGF
T
E
LTL
N
N
ELL
AQ
GKIMID
S
A
S
G
TL
PDGTVFS
I
P
DQ
D
A
LP
D
P
-
LH
P
QN
F
P
D
ER
S
RN
IYLALPV
A
S
D
V
R
NEI
-
---
S
DG
RR
IG
RY
--
R
LNYAD
VRD
L
H
SE
EGD
ART
L
T
LG
Q
L
T
PRI
M
S
--
GAED
MS
AYITLPL
C
RI
SD
RHA
D
GSLT
L
DD
D
FIP
SC
QN
IQ
VS
KK
L
RVY
L
K
EVQ
GA
I
GG
RA
S
DLA
N
--
RI
G
S
PAQ
SG
--
IADVAEFMMLQ
L
LNR
N
Q
TR
FTH
RA
R
RSQ
LHPE
DF
Y
L
DLA
G
LLGELMTF
T
E
P
-
S
RLPC
P
L
D
-------
V
Y
D
H
H
DL
TK
TF
-
K
TL
L
PEV
K
RAL
H
TVL
S
PRA
V
NL
P
L
HLRD
G
I
-
W
---
Q
A
D
IHD
TE
LLQ
S
A
T
FVLAVAA
N
-
V
P
V
DQIQ
R
QFIQQSKI
S
SPEKI
RN
MVSVQIPGI
P
L
RA
LM
V
APRQLP
Y
H
S
G
FS
YFELDK
SGQ
AW
TE
M
AA
AG
AV
ALH
V
SGSFPDLN
M
QLWAIRG
fig|340185.4.peg.1618
Escherichia coli E22
MATTRNKVMW
Q
EG
M
L
MR
P
H
HFQQQQRY
ND
YL
DNQ
R
FR
A
MNDLS
WGF
T
E
LTL
N
N
ELL
AQ
GKIMID
S
A
S
G
TL
PDGTVFS
I
P
DQ
D
A
LP
D
P
-
LH
P
QN
F
P
D
ER
S
RN
IYLALPV
A
S
D
V
R
NEI
-
---
S
DG
RR
IG
RY
--
R
LNYAD
VRD
L
H
SE
EGD
ART
L
T
LG
Q
L
T
PRI
M
S
--
GAED
MS
AYITLPL
C
RI
SD
RHA
D
GSLT
L
DD
D
FIP
SC
QN
IQ
VS
KK
L
RVY
L
K
EVQ
GA
I
GG
RA
S
DLA
N
--
RI
G
S
PAQ
SG
--
IADVAEFMMLQ
L
LNR
N
Q
TR
FTH
RA
R
RSQ
LHPE
DF
Y
L
DLA
G
LLGELMTF
T
E
P
-
S
RLPC
P
L
D
-------
V
Y
D
H
H
DL
TK
TF
-
K
TL
L
PEV
K
RAL
H
TVL
S
PRA
V
NL
P
L
HLRD
G
I
-
W
---
Q
A
D
IHD
TE
LLQ
S
A
T
FVLAVAA
N
-
V
P
V
DQIQ
R
QFIQQSKI
S
SPEKI
RN
MVSVQIPGI
P
L
RA
LM
V
APRQLP
Y
H
S
G
FS
YFELDK
SGQ
AW
TE
M
AA
AG
AV
ALH
V
SGSFPDLN
M
QLWAIRG
fig|679204.3.peg.4976
Escherichia coli MS 145-7
MATTRNKVMW
Q
EG
M
L
MR
P
H
HFQQQQRY
ND
YL
DNQ
R
FR
A
MNDLS
WGF
T
E
LTL
N
N
ELL
AQ
GKIMID
S
A
S
G
TL
PDGTVFS
I
P
DQ
D
A
LP
D
P
-
LH
P
QN
F
P
D
ER
S
RN
IYLALPV
A
S
D
V
R
NEI
-
---
S
DG
RR
IG
RY
--
R
LNYAD
VRD
L
H
SE
EGD
ART
L
T
LG
Q
L
T
PRI
M
S
--
GAED
MS
AYITLPL
C
RI
SD
RHA
D
GSLT
L
DD
D
FIP
SC
QN
IQ
VS
KK
L
RVY
L
K
EVQ
GA
I
GG
RA
S
DLA
N
--
RI
G
S
PAQ
SG
--
IADVAEFMMLQ
L
LNR
N
Q
TR
FTH
RA
R
RSQ
LHPE
DF
Y
L
DLA
G
LLGELMTF
T
E
P
-
S
RLPC
P
L
D
-------
V
Y
D
H
H
DL
TK
TF
-
K
TL
L
PEV
K
RAL
H
TVL
S
PRA
V
NL
P
L
HLRD
G
I
-
W
---
Q
A
D
IHD
TE
LLQ
S
A
T
FVLAVAA
N
-
V
P
V
DQIQ
R
QFIQQSKI
S
SPEKI
RN
MVSVQIPGI
P
L
RA
LM
V
APRQLP
Y
H
S
G
FS
YFELDK
SGQ
AW
TE
M
AA
AG
AV
ALH
V
SGSFPDLN
M
QLWAIRG
fig|409438.11.peg.343
Escherichia coli SE11
MATTRNKVMW
Q
EG
M
L
MR
P
H
HFQQQQRY
ND
YL
DNQ
R
FR
A
MNDLS
WGF
T
E
LTL
N
N
ELL
AQ
GKIMID
S
A
S
G
TL
PDGTVFS
I
P
DQ
D
A
LP
D
P
-
LH
P
QN
F
P
D
ER
S
RN
IYLALPV
A
S
D
V
R
NEI
-
---
S
DG
RR
IG
RY
--
R
LNYAD
VRD
L
H
SE
EGD
ART
L
T
LG
Q
L
T
PRI
M
S
--
GAED
MS
AYITLPL
C
RI
SD
RHA
D
GSLT
L
DD
D
FIP
SC
QN
IQ
VS
KK
L
RVY
L
K
EVQ
GA
I
GG
RA
S
DLA
N
--
RI
G
S
PAQ
SG
--
IADVAEFMMLQ
L
LNR
N
Q
TR
FTH
RA
R
RSQ
LHPE
DF
Y
L
DLA
G
LLGELMTF
T
E
P
-
S
RLPC
P
L
D
-------
V
Y
D
H
H
DL
TK
TF
-
K
TL
L
PEV
K
RAL
H
TVL
S
PRA
V
NL
P
L
HLRD
G
I
-
W
---
Q
A
D
IHD
TE
LLQ
S
A
T
FVLAVAA
N
-
V
P
V
DQIQ
R
QFIQQSKI
S
SPEKI
RN
MVSVQIPGI
P
L
RA
LM
V
APRQLP
Y
H
S
G
FS
YFELDK
SGQ
AW
TE
M
AA
AG
AV
ALH
V
SGSFPDLN
M
QLWAIRG
fig|656419.3.peg.394
Escherichia coli M718
MATTRNKVMW
Q
EG
M
L
MR
P
H
HFQQQQRY
ND
YL
DNQ
R
FR
A
MNDLS
WGF
T
E
LTL
N
N
ELL
AQ
GKIMID
S
A
S
G
TL
PDGTVFS
I
P
DQ
D
A
LP
D
P
-
LH
P
QN
F
P
D
ER
S
RN
IYLALPV
T
S
D
V
R
NEI
-
---
S
DG
RR
IG
RY
--
R
LNYAD
VRD
L
H
SE
EGD
ART
L
T
LG
Q
L
T
PRI
M
S
--
GAED
MS
AYITLPL
C
RI
SD
RHA
D
GSLT
L
DD
D
FIP
SC
QN
IQ
VS
KK
L
RVY
L
K
EVQ
GA
I
GG
RA
S
DLA
N
--
RI
G
S
PAQ
SG
--
IADVAEFMMLQ
L
LNR
N
Q
TR
FTH
RA
R
RSQ
LHPE
DF
Y
L
DLA
G
LLGELMTF
T
E
P
-
S
RLPC
P
L
D
-------
V
Y
D
H
H
DL
TK
TF
-
K
TL
L
PEV
K
RAL
H
TVL
S
PRA
V
NL
P
L
HLRD
G
I
-
W
---
Q
A
D
V
HD
SE
LLQ
S
A
T
FVLAVAA
N
-
MP
V
DQIQ
R
QFIQQSKI
S
SPEKI
RN
MVSVQIPGI
P
L
RA
LM
V
APRQLP
Y
H
S
G
FS
YFELDK
SGQ
AW
TE
M
AA
AG
AV
ALH
V
SGSFPDLN
M
QLWAIRG
fig|749538.3.peg.2636
Escherichia coli MS 116-1
MATTRNKVMW
Q
EG
M
L
MR
P
H
HFQQQQRY
ND
YL
DNQ
R
FR
A
MNDLS
WGF
T
E
LTL
N
N
ELL
AQ
GKIMID
S
A
S
G
TL
PDGTVFS
I
P
DQ
D
A
LP
D
P
-
LH
P
QN
F
P
D
ER
S
RN
IYLALPV
A
S
D
V
R
NEI
-
---
S
DG
RR
IG
RY
--
R
LNYAD
VRD
L
H
SE
EGD
ART
L
T
LG
Q
L
T
PRI
M
S
--
GAED
MS
AYITLPL
C
RI
SN
RHA
D
GSLT
L
DD
D
FIP
SC
QN
IQ
VS
KK
L
RVY
L
K
EVQ
GA
I
GG
RA
S
DLA
N
--
RI
G
S
PAQ
SG
--
IADVAEFMMLQ
L
LNR
N
Q
TR
FTH
RA
R
RSQ
LHPE
DF
Y
L
DLA
G
LLGELMTF
T
E
P
-
S
RLPC
P
L
D
-------
V
Y
D
H
H
DL
TK
TF
-
K
TL
L
PEV
K
RAL
H
TVL
S
PRA
V
NL
P
L
HLRD
G
I
-
W
---
Q
A
D
IHD
TE
LLQ
S
A
T
FVLAVAA
N
-
V
P
V
DQIQ
R
QFIQQSKI
S
SPEKI
RN
MVSVQIPGI
P
L
RA
LM
V
APRQLP
Y
H
S
G
FS
YFELDK
SGQ
AW
TE
M
AA
AG
AV
ALH
V
SGSFPDLN
M
QLWAIRG
fig|749548.3.peg.5091
Escherichia coli MS 196-1
MATTRNKVMW
Q
EG
M
L
MR
P
H
HFQQQQRY
ND
YL
DNQ
R
FR
A
MNDLS
WGF
T
E
LTL
N
N
ELL
AQ
GKIMID
S
A
S
G
TL
PDGTVFS
I
P
DQ
D
A
LP
D
P
-
LH
P
QN
F
P
D
ER
S
RN
IYLALPV
A
S
D
V
R
NEI
-
---
S
DG
RR
IG
RY
--
R
LNYAD
VRD
L
H
SE
EGD
ART
L
T
LG
Q
L
T
PRI
M
S
--
GAED
MS
AYITLPL
C
RI
SN
RHA
D
GSLT
L
DD
D
FIP
SC
QN
IQ
VS
KK
L
RVY
L
K
EVQ
GA
I
GG
RA
S
DLA
N
--
RI
G
S
PAQ
SG
--
IADVAEFMMLQ
L
LNR
N
Q
TR
FTH
RA
R
RSQ
LHPE
DF
Y
L
DLA
G
LLGELMTF
T
E
P
-
S
RLPC
P
L
D
-------
V
Y
D
H
H
DL
TK
TF
-
K
TL
L
PEV
K
RAL
H
TVL
S
PRA
V
NL
P
L
HLRD
G
I
-
W
---
Q
A
D
IHD
TE
LLQ
S
A
T
FVLAVAA
N
-
V
P
V
DQIQ
R
QFIQQSKI
S
SPEKI
RN
MVSVQIPGI
P
L
RA
LM
V
APRQLP
Y
H
S
G
FS
YFELDK
SGQ
AW
TE
M
AA
AG
AV
ALH
V
SGSFPDLN
M
QLWAIRG
fig|585034.4.peg.226
Escherichia coli IAI1
MATTRNKVMW
Q
EG
M
L
MR
P
H
HFQQQQRY
ND
YL
DNQ
R
FR
A
MNDLS
WGF
T
E
LTL
N
N
ELL
AQ
GKIMID
S
A
S
G
TL
PDGTVFS
I
P
DQ
D
A
LP
D
P
-
LH
P
QN
F
P
D
ER
S
RN
IYLALPV
A
S
D
V
R
NEI
-
---
S
DG
RR
TG
RY
--
R
LNYAD
VRD
L
H
SE
EGD
ART
L
T
LG
Q
L
T
PRI
M
S
--
GAED
MS
AYITLPL
C
RI
SD
RHA
D
GSLT
L
DD
D
FIP
SC
QN
IQ
VS
KK
L
RVY
L
K
EVQ
GA
I
GG
RA
S
DLA
N
--
RI
G
S
PAQ
SG
--
IADVAEFMMLQ
L
LNR
N
Q
TR
FTH
RA
R
RSQ
LHPE
DF
Y
L
DLA
G
LLGELMTF
T
E
P
-
S
RLPC
P
L
D
-------
V
Y
D
H
H
DL
TK
TF
-
K
TL
L
PEV
K
RAL
H
TVL
S
PRA
V
NL
P
L
HLRD
G
I
-
W
---
Q
A
D
IHD
TE
LLQ
S
A
T
FVLAVAA
N
-
V
P
V
DQIQ
R
QFIQQSKI
S
SPEKI
RN
MVSVQIPGI
P
L
RA
LM
V
APRQLP
Y
H
S
G
FS
YFELDK
SGQ
AW
TE
M
AA
AG
AV
ALH
V
SGSFPDLN
M
QLWAIRG
fig|585034.5.peg.226
Escherichia coli IAI1
MATTRNKVMW
Q
EG
M
L
MR
P
H
HFQQQQRY
ND
YL
DNQ
R
FR
A
MNDLS
WGF
T
E
LTL
N
N
ELL
AQ
GKIMID
S
A
S
G
TL
PDGTVFS
I
P
DQ
D
A
LP
D
P
-
LH
P
QN
F
P
D
ER
S
RN
IYLALPV
A
S
D
V
R
NEI
-
---
S
DG
RR
TG
RY
--
R
LNYAD
VRD
L
H
SE
EGD
ART
L
T
LG
Q
L
T
PRI
M
S
--
GAED
MS
AYITLPL
C
RI
SD
RHA
D
GSLT
L
DD
D
FIP
SC
QN
IQ
VS
KK
L
RVY
L
K
EVQ
GA
I
GG
RA
S
DLA
N
--
RI
G
S
PAQ
SG
--
IADVAEFMMLQ
L
LNR
N
Q
TR
FTH
RA
R
RSQ
LHPE
DF
Y
L
DLA
G
LLGELMTF
T
E
P
-
S
RLPC
P
L
D
-------
V
Y
D
H
H
DL
TK
TF
-
K
TL
L
PEV
K
RAL
H
TVL
S
PRA
V
NL
P
L
HLRD
G
I
-
W
---
Q
A
D
IHD
TE
LLQ
S
A
T
FVLAVAA
N
-
V
P
V
DQIQ
R
QFIQQSKI
S
SPEKI
RN
MVSVQIPGI
P
L
RA
LM
V
APRQLP
Y
H
S
G
FS
YFELDK
SGQ
AW
TE
M
AA
AG
AV
ALH
V
SGSFPDLN
M
QLWAIRG
fig|679205.4.peg.4242
Escherichia coli MS 124-1
MATTRNKVMW
Q
EG
M
L
MR
P
H
HFQQQQRY
ND
YL
DNQ
R
FR
A
MNDLS
WGF
T
E
LTL
N
N
ELL
AQ
GKIMID
S
A
S
G
TL
PDGTVFS
I
P
DQ
D
A
LP
D
P
-
LH
P
QN
F
P
D
ER
S
RN
IYLALPV
A
S
D
V
R
NEI
-
---
S
DG
RR
TG
RY
--
R
LNYAD
VRD
L
H
SE
EGD
ART
L
T
LG
Q
L
T
PRI
M
S
--
GAED
MS
AYITLPL
C
RI
SD
RHA
D
GSLT
L
DD
D
FIP
SC
QN
IQ
VS
KK
L
RVY
L
K
EVQ
GA
I
GG
RA
S
DLA
N
--
RI
G
S
PAQ
SG
--
IADVAEFMMLQ
L
LNR
N
Q
TR
FTH
RA
R
RSQ
LHPE
DF
Y
L
DLA
G
LLGELMTF
T
E
P
-
S
RLPC
P
L
D
-------
V
Y
D
H
H
DL
TK
TF
-
K
TL
L
PEV
K
RAL
H
TVL
S
PRA
V
NL
P
L
HLRD
G
I
-
W
---
Q
A
D
IHD
TE
LLQ
S
A
T
FVLAVAA
N
-
V
P
V
DQIQ
R
QFIQQSKI
S
SPEKI
RN
MVSVQIPGI
P
L
RA
LM
V
APRQLP
Y
H
S
G
FS
YFELDK
SGQ
AW
TE
M
AA
AG
AV
ALH
V
SGSFPDLN
M
QLWAIRG
fig|749533.3.peg.3431
Escherichia coli MS 84-1
MATTRNKVMW
Q
EG
M
L
MR
P
H
HFQQQQRY
ND
YL
DNQ
R
FR
A
MNDLS
WGF
T
E
LTL
N
N
ELL
AQ
GKIMID
S
A
S
G
TL
PDGTVFS
I
P
DQ
D
A
LP
D
P
-
LH
P
QN
F
P
D
ER
S
RN
IYLALPV
A
S
D
V
R
NEI
-
---
S
DG
RR
TG
RY
--
R
LNYAD
VRD
L
H
SE
EGD
ART
L
T
LG
Q
L
T
PRI
M
S
--
GAED
MS
AYITLPL
C
RI
SD
RHA
D
GSLT
L
DD
D
FIP
SC
QN
IQ
VS
KK
L
RVY
L
K
EVQ
GA
I
GG
RA
S
DLA
N
--
RI
G
S
PAQ
SG
--
IADVAEFMMLQ
L
LNR
N
Q
TR
FTH
RA
R
RSQ
LHPE
DF
Y
L
DLA
G
LLGELMTF
T
E
P
-
S
RLPC
P
L
D
-------
V
Y
D
H
H
DL
TK
TF
-
K
TL
L
PEV
K
RAL
H
TVL
S
PRA
V
NL
P
L
HLRD
G
I
-
W
---
Q
A
D
IHD
TE
LLQ
S
A
T
FVLAVAA
N
-
V
P
V
DQIQ
R
QFIQQSKI
S
SPEKI
RN
MVSVQIPGI
P
L
RA
LM
V
APRQLP
Y
H
S
G
FS
YFELDK
SGQ
AW
TE
M
AA
AG
AV
ALH
V
SGSFPDLN
M
QLWAIRG
fig|701177.3.peg.228
Escherichia coli O55:H7 str. CB9615
MATTRNKVMW
Q
EG
M
L
MR
P
H
HFQQQQRY
ND
YL
DNQ
R
FR
A
MNDLS
WGF
T
E
LTL
N
N
ELL
AQ
GKIMID
S
A
S
G
TL
PDGTVFS
I
P
DQ
D
A
LP
D
P
-
LY
P
QN
F
P
D
ER
S
RN
IYLALPV
A
S
D
V
R
NEI
-
---
S
DG
RR
IG
RY
--
R
LNYAD
VRD
L
H
SE
EGD
ART
L
T
LG
Q
L
T
PRI
M
S
--
GAED
MS
AYITLPL
C
RI
SD
RHA
D
GSLT
L
DD
D
FIP
SC
QN
IQ
VS
KK
L
RVY
L
K
EVQ
GA
I
GG
RA
S
DLA
N
--
RI
G
S
PAQ
SG
--
IADVAEFMMLQ
L
LNR
N
Q
TR
FTH
RA
R
RSQ
LHPE
DF
Y
L
DLA
G
LLGELMTF
T
E
P
-
S
RLPC
P
L
D
-------
V
Y
D
H
H
DL
TK
TF
-
K
TL
L
PEV
K
RAL
H
TVL
S
PRA
V
NL
P
L
HLRD
G
I
-
W
---
Q
A
D
V
HD
SE
LLQ
S
A
T
FVLAVAA
N
-
MP
V
DQIQ
R
QFIQQSKI
S
SPEKI
RN
MVSVQIPGI
P
L
RA
LM
V
APRQLP
Y
H
S
G
FS
YFELDK
SGQ
AW
TE
M
AA
AG
AV
ALH
V
SGSFPDLN
M
QLWAIRG
fig|562.371.peg.815
Escherichia coli 1044A
MATTRNKVMW
Q
EG
M
L
MR
P
H
HFQQQQRY
ND
YL
DNQ
R
FR
A
MNDLS
WGF
T
E
LTL
N
N
ELL
AQ
GKIMID
S
A
S
G
TL
PDGTVFS
I
P
DQ
D
A
LP
D
P
-
LH
P
QN
F
P
D
ER
S
RN
IYLALPV
A
S
D
V
R
NEI
-
---
S
DG
RR
IG
RY
--
R
LNYAD
VRD
L
H
SE
EGD
ART
L
T
LG
Q
L
T
PRI
M
S
--
GAED
MS
AYITLPL
C
RI
SD
RHA
D
GSLT
L
DD
D
FIP
SC
QN
IQ
VS
KK
L
RVY
L
K
EVQ
GA
I
GG
RA
S
DLA
N
--
RI
G
S
PAQ
SG
--
IADVAEFMMLQ
L
LNR
N
Q
TR
FTH
RA
R
RSQ
LHPE
DF
Y
L
DLA
E
LLGELMTF
T
E
P
-
S
RLPC
P
L
D
-------
V
Y
D
H
H
DL
TK
TF
-
K
TL
L
PEV
K
RAL
H
TVL
S
PRA
V
NL
P
L
HLRD
G
I
-
W
---
Q
A
D
V
HD
SE
LLQ
S
A
T
FVLAVAA
N
-
MP
V
DQIQ
R
QFIQQSKI
S
SPEKI
RN
MVSVQIPGI
P
L
RA
LM
V
APRQLP
Y
H
S
G
FS
YFELDK
SGQ
AW
TE
M
AA
AG
AV
ALH
V
SGSFPDLN
M
QLWAIRG
fig|562.373.peg.2686
Escherichia coli 1125A
MATTRNKVMW
Q
EG
M
L
MR
P
H
HFQQQQRY
ND
YL
DNQ
R
FR
A
MNDLS
WGF
T
E
LTL
N
N
ELL
AQ
GKIMID
S
A
S
G
TL
PDGTVFS
I
P
DQ
D
A
LP
D
P
-
LH
P
QN
F
P
D
ER
S
RN
IYLALPV
A
S
D
V
R
NEI
-
---
S
DG
RR
IG
RY
--
R
LNYAD
VRD
L
H
SE
EGD
ART
L
T
LG
Q
L
T
PRI
M
S
--
GAED
MS
AYITLPL
C
RI
SD
RHA
D
GSLT
L
DD
D
FIP
SC
QN
IQ
VS
KK
L
RVY
L
K
EVQ
GA
I
GG
RA
S
DLA
N
--
RI
G
S
PAQ
SG
--
IADVAEFMMLQ
L
LNR
N
Q
TR
FTH
RA
R
RSQ
LHPE
DF
Y
L
DLA
E
LLGELMTF
T
E
P
-
S
RLPC
P
L
D
-------
V
Y
D
H
H
DL
TK
TF
-
K
TL
L
PEV
K
RAL
H
TVL
S
PRA
V
NL
P
L
HLRD
G
I
-
W
---
Q
A
D
V
HD
SE
LLQ
S
A
T
FVLAVAA
N
-
MP
V
DQIQ
R
QFIQQSKI
S
SPEKI
RN
MVSVQIPGI
P
L
RA
LM
V
APRQLP
Y
H
S
G
FS
YFELDK
SGQ
AW
TE
M
AA
AG
AV
ALH
V
SGSFPDLN
M
QLWAIRG
fig|562.372.peg.2883
Escherichia coli 1212A
MATTRNKVMW
Q
EG
M
L
MR
P
H
HFQQQQRY
ND
YL
DNQ
R
FR
A
MNDLS
WGF
T
E
LTL
N
N
ELL
AQ
GKIMID
S
A
S
G
TL
PDGTVFS
I
P
DQ
D
A
LP
D
P
-
LH
P
QN
F
P
D
ER
S
RN
IYLALPV
A
S
D
V
R
NEI
-
---
S
DG
RR
IG
RY
--
R
LNYAD
VRD
L
H
SE
EGD
ART
L
T
LG
Q
L
T
PRI
M
S
--
GAED
MS
AYITLPL
C
RI
SD
RHA
D
GSLT
L
DD
D
FIP
SC
QN
IQ
VS
KK
L
RVY
L
K
EVQ
GA
I
GG
RA
S
DLA
N
--
RI
G
S
PAQ
SG
--
IADVAEFMMLQ
L
LNR
N
Q
TR
FTH
RA
R
RSQ
LHPE
DF
Y
L
DLA
E
LLGELMTF
T
E
P
-
S
RLPC
P
L
D
-------
V
Y
D
H
H
DL
TK
TF
-
K
TL
L
PEV
K
RAL
H
TVL
S
PRA
V
NL
P
L
HLRD
G
I
-
W
---
Q
A
D
V
HD
SE
LLQ
S
A
T
FVLAVAA
N
-
MP
V
DQIQ
R
QFIQQSKI
S
SPEKI
RN
MVSVQIPGI
P
L
RA
LM
V
APRQLP
Y
H
S
G
FS
YFELDK
SGQ
AW
TE
M
AA
AG
AV
ALH
V
SGSFPDLN
M
QLWAIRG
fig|562.374.peg.1317
Escherichia coli 536A
MATTRNKVMW
Q
EG
M
L
MR
P
H
HFQQQQRY
ND
YL
DNQ
R
FR
A
MNDLS
WGF
T
E
LTL
N
N
ELL
AQ
GKIMID
S
A
S
G
TL
PDGTVFS
I
P
DQ
D
A
LP
D
P
-
LH
P
QN
F
P
D
ER
S
RN
IYLALPV
A
S
D
V
R
NEI
-
---
S
DG
RR
IG
RY
--
R
LNYAD
VRD
L
H
SE
EGD
ART
L
T
LG
Q
L
T
PRI
M
S
--
GAED
MS
AYITLPL
C
RI
SD
RHA
D
GSLT
L
DD
D
FIP
SC
QN
IQ
VS
KK
L
RVY
L
K
EVQ
GA
I
GG
RA
S
DLA
N
--
RI
G
S
PAQ
SG
--
IADVAEFMMLQ
L
LNR
N
Q
TR
FTH
RA
R
RSQ
LHPE
DF
Y
L
DLA
E
LLGELMTF
T
E
P
-
S
RLPC
P
L
D
-------
V
Y
D
H
H
DL
TK
TF
-
K
TL
L
PEV
K
RAL
H
TVL
S
PRA
V
NL
P
L
HLRD
G
I
-
W
---
Q
A
D
V
HD
SE
LLQ
S
A
T
FVLAVAA
N
-
MP
V
DQIQ
R
QFIQQSKI
S
SPEKI
RN
MVSVQIPGI
P
L
RA
LM
V
APRQLP
Y
H
S
G
FS
YFELDK
SGQ
AW
TE
M
AA
AG
AV
ALH
V
SGSFPDLN
M
QLWAIRG
fig|83334.1.peg.312
Escherichia coli O157:H7
MATTRNKVMW
Q
EG
M
L
MR
P
H
HFQQQQRY
ND
YL
DNQ
R
FR
A
MNDLS
WGF
T
E
LTL
N
N
ELL
AQ
GKIMID
S
A
S
G
TL
PDGTVFS
I
P
DQ
D
A
LP
D
P
-
LH
P
QN
F
P
D
ER
S
RN
IYLALPV
A
S
D
V
R
NEI
-
---
S
DG
RR
IG
RY
--
R
LNYAD
VRD
L
H
SE
EGD
ART
L
T
LG
Q
L
T
PRI
M
S
--
GAED
MS
AYITLPL
C
RI
SD
RHA
D
GSLT
L
DD
D
FIP
SC
QN
IQ
VS
KK
L
RVY
L
K
EVQ
GA
I
GG
RA
S
DLA
N
--
RI
G
S
PAQ
SG
--
IADVAEFMMLQ
L
LNR
N
Q
TR
FTH
RA
R
RSQ
LHPE
DF
Y
L
DLA
E
LLGELMTF
T
E
P
-
S
RLPC
P
L
D
-------
V
Y
D
H
H
DL
TK
TF
-
K
TL
L
PEV
K
RAL
H
TVL
S
PRA
V
NL
P
L
HLRD
G
I
-
W
---
Q
A
D
V
HD
SE
LLQ
S
A
T
FVLAVAA
N
-
MP
V
DQIQ
R
QFIQQSKI
S
SPEKI
RN
MVSVQIPGI
P
L
RA
LM
V
APRQLP
Y
H
S
G
FS
YFELDK
SGQ
AW
TE
M
AA
AG
AV
ALH
V
SGSFPDLN
M
QLWAIRG
fig|155864.1.peg.225
Escherichia coli O157:H7 EDL933
MATTRNKVMW
Q
EG
M
L
MR
P
H
HFQQQQRY
ND
YL
DNQ
R
FR
A
MNDLS
WGF
T
E
LTL
N
N
ELL
AQ
GKIMID
S
A
S
G
TL
PDGTVFS
I
P
DQ
D
A
LP
D
P
-
LH
P
QN
F
P
D
ER
S
RN
IYLALPV
A
S
D
V
R
NEI
-
---
S
DG
RR
IG
RY
--
R
LNYAD
VRD
L
H
SE
EGD
ART
L
T
LG
Q
L
T
PRI
M
S
--
GAED
MS
AYITLPL
C
RI
SD
RHA
D
GSLT
L
DD
D
FIP
SC
QN
IQ
VS
KK
L
RVY
L
K
EVQ
GA
I
GG
RA
S
DLA
N
--
RI
G
S
PAQ
SG
--
IADVAEFMMLQ
L
LNR
N
Q
TR
FTH
RA
R
RSQ
LHPE
DF
Y
L
DLA
E
LLGELMTF
T
E
P
-
S
RLPC
P
L
D
-------
V
Y
D
H
H
DL
TK
TF
-
K
TL
L
PEV
K
RAL
H
TVL
S
PRA
V
NL
P
L
HLRD
G
I
-
W
---
Q
A
D
V
HD
SE
LLQ
S
A
T
FVLAVAA
N
-
MP
V
DQIQ
R
QFIQQSKI
S
SPEKI
RN
MVSVQIPGI
P
L
RA
LM
V
APRQLP
Y
H
S
G
FS
YFELDK
SGQ
AW
TE
M
AA
AG
AV
ALH
V
SGSFPDLN
M
QLWAIRG
fig|155864.8.peg.226
Escherichia coli O157:H7 EDL933
MATTRNKVMW
Q
EG
M
L
MR
P
H
HFQQQQRY
ND
YL
DNQ
R
FR
A
MNDLS
WGF
T
E
LTL
N
N
ELL
AQ
GKIMID
S
A
S
G
TL
PDGTVFS
I
P
DQ
D
A
LP
D
P
-
LH
P
QN
F
P
D
ER
S
RN
IYLALPV
A
S
D
V
R
NEI
-
---
S
DG
RR
IG
RY
--
R
LNYAD
VRD
L
H
SE
EGD
ART
L
T
LG
Q
L
T
PRI
M
S
--
GAED
MS
AYITLPL
C
RI
SD
RHA
D
GSLT
L
DD
D
FIP
SC
QN
IQ
VS
KK
L
RVY
L
K
EVQ
GA
I
GG
RA
S
DLA
N
--
RI
G
S
PAQ
SG
--
IADVAEFMMLQ
L
LNR
N
Q
TR
FTH
RA
R
RSQ
LHPE
DF
Y
L
DLA
E
LLGELMTF
T
E
P
-
S
RLPC
P
L
D
-------
V
Y
D
H
H
DL
TK
TF
-
K
TL
L
PEV
K
RAL
H
TVL
S
PRA
V
NL
P
L
HLRD
G
I
-
W
---
Q
A
D
V
HD
SE
LLQ
S
A
T
FVLAVAA
N
-
MP
V
DQIQ
R
QFIQQSKI
S
SPEKI
RN
MVSVQIPGI
P
L
RA
LM
V
APRQLP
Y
H
S
G
FS
YFELDK
SGQ
AW
TE
M
AA
AG
AV
ALH
V
SGSFPDLN
M
QLWAIRG
fig|444454.5.peg.4687
Escherichia coli O157:H7 str. EC4024
MATTRNKVMW
Q
EG
M
L
MR
P
H
HFQQQQRY
ND
YL
DNQ
R
FR
A
MNDLS
WGF
T
E
LTL
N
N
ELL
AQ
GKIMID
S
A
S
G
TL
PDGTVFS
I
P
DQ
D
A
LP
D
P
-
LH
P
QN
F
P
D
ER
S
RN
IYLALPV
A
S
D
V
R
NEI
-
---
S
DG
RR
IG
RY
--
R
LNYAD
VRD
L
H
SE
EGD
ART
L
T
LG
Q
L
T
PRI
M
S
--
GAED
MS
AYITLPL
C
RI
SD
RHA
D
GSLT
L
DD
D
FIP
SC
QN
IQ
VS
KK
L
RVY
L
K
EVQ
GA
I
GG
RA
S
DLA
N
--
RI
G
S
PAQ
SG
--
IADVAEFMMLQ
L
LNR
N
Q
TR
FTH
RA
R
RSQ
LHPE
DF
Y
L
DLA
E
LLGELMTF
T
E
P
-
S
RLPC
P
L
D
-------
V
Y
D
H
H
DL
TK
TF
-
K
TL
L
PEV
K
RAL
H
TVL
S
PRA
V
NL
P
L
HLRD
G
I
-
W
---
Q
A
D
V
HD
SE
LLQ
S
A
T
FVLAVAA
N
-
MP
V
DQIQ
R
QFIQQSKI
S
SPEKI
RN
MVSVQIPGI
P
L
RA
LM
V
APRQLP
Y
H
S
G
FS
YFELDK
SGQ
AW
TE
M
AA
AG
AV
ALH
V
SGSFPDLN
M
QLWAIRG
fig|444449.5.peg.4142
Escherichia coli O157:H7 str. EC4042
MATTRNKVMW
Q
EG
M
L
MR
P
H
HFQQQQRY
ND
YL
DNQ
R
FR
A
MNDLS
WGF
T
E
LTL
N
N
ELL
AQ
GKIMID
S
A
S
G
TL
PDGTVFS
I
P
DQ
D
A
LP
D
P
-
LH
P
QN
F
P
D
ER
S
RN
IYLALPV
A
S
D
V
R
NEI
-
---
S
DG
RR
IG
RY
--
R
LNYAD
VRD
L
H
SE
EGD
ART
L
T
LG
Q
L
T
PRI
M
S
--
GAED
MS
AYITLPL
C
RI
SD
RHA
D
GSLT
L
DD
D
FIP
SC
QN
IQ
VS
KK
L
RVY
L
K
EVQ
GA
I
GG
RA
S
DLA
N
--
RI
G
S
PAQ
SG
--
IADVAEFMMLQ
L
LNR
N
Q
TR
FTH
RA
R
RSQ
LHPE
DF
Y
L
DLA
E
LLGELMTF
T
E
P
-
S
RLPC
P
L
D
-------
V
Y
D
H
H
DL
TK
TF
-
K
TL
L
PEV
K
RAL
H
TVL
S
PRA
V
NL
P
L
HLRD
G
I
-
W
---
Q
A
D
V
HD
SE
LLQ
S
A
T
FVLAVAA
N
-
MP
V
DQIQ
R
QFIQQSKI
S
SPEKI
RN
MVSVQIPGI
P
L
RA
LM
V
APRQLP
Y
H
S
G
FS
YFELDK
SGQ
AW
TE
M
AA
AG
AV
ALH
V
SGSFPDLN
M
QLWAIRG
fig|444448.5.peg.2897
Escherichia coli O157:H7 str. EC4045
MATTRNKVMW
Q
EG
M
L
MR
P
H
HFQQQQRY
ND
YL
DNQ
R
FR
A
MNDLS
WGF
T
E
LTL
N
N
ELL
AQ
GKIMID
S
A
S
G
TL
PDGTVFS
I
P
DQ
D
A
LP
D
P
-
LH
P
QN
F
P
D
ER
S
RN
IYLALPV
A
S
D
V
R
NEI
-
---
S
DG
RR
IG
RY
--
R
LNYAD
VRD
L
H
SE
EGD
ART
L
T
LG
Q
L
T
PRI
M
S
--
GAED
MS
AYITLPL
C
RI
SD
RHA
D
GSLT
L
DD
D
FIP
SC
QN
IQ
VS
KK
L
RVY
L
K
EVQ
GA
I
GG
RA
S
DLA
N
--
RI
G
S
PAQ
SG
--
IADVAEFMMLQ
L
LNR
N
Q
TR
FTH
RA
R
RSQ
LHPE
DF
Y
L
DLA
E
LLGELMTF
T
E
P
-
S
RLPC
P
L
D
-------
V
Y
D
H
H
DL
TK
TF
-
K
TL
L
PEV
K
RAL
H
TVL
S
PRA
V
NL
P
L
HLRD
G
I
-
W
---
Q
A
D
V
HD
SE
LLQ
S
A
T
FVLAVAA
N
-
MP
V
DQIQ
R
QFIQQSKI
S
SPEKI
RN
MVSVQIPGI
P
L
RA
LM
V
APRQLP
Y
H
S
G
FS
YFELDK
SGQ
AW
TE
M
AA
AG
AV
ALH
V
SGSFPDLN
M
QLWAIRG
fig|444453.5.peg.4259
Escherichia coli O157:H7 str. EC4076
MATTRNKVMW
Q
EG
M
L
MR
P
H
HFQQQQRY
ND
YL
DNQ
R
FR
A
MNDLS
WGF
T
E
LTL
N
N
ELL
AQ
GKIMID
S
A
S
G
TL
PDGTVFS
I
P
DQ
D
A
LP
D
P
-
LH
P
QN
F
P
D
ER
S
RN
IYLALPV
A
S
D
V
R
NEI
-
---
S
DG
RR
IG
RY
--
R
LNYAD
VRD
L
H
SE
EGD
ART
L
T
LG
Q
L
T
PRI
M
S
--
GAED
MS
AYITLPL
C
RI
SD
RHA
D
GSLT
L
DD
D
FIP
SC
QN
IQ
VS
KK
L
RVY
L
K
EVQ
GA
I
GG
RA
S
DLA
N
--
RI
G
S
PAQ
SG
--
IADVAEFMMLQ
L
LNR
N
Q
TR
FTH
RA
R
RSQ
LHPE
DF
Y
L
DLA
E
LLGELMTF
T
E
P
-
S
RLPC
P
L
D
-------
V
Y
D
H
H
DL
TK
TF
-
K
TL
L
PEV
K
RAL
H
TVL
S
PRA
V
NL
P
L
HLRD
G
I
-
W
---
Q
A
D
V
HD
SE
LLQ
S
A
T
FVLAVAA
N
-
MP
V
DQIQ
R
QFIQQSKI
S
SPEKI
RN
MVSVQIPGI
P
L
RA
LM
V
APRQLP
Y
H
S
G
FS
YFELDK
SGQ
AW
TE
M
AA
AG
AV
ALH
V
SGSFPDLN
M
QLWAIRG
fig|444452.5.peg.3153
Escherichia coli O157:H7 str. EC4113
MATTRNKVMW
Q
EG
M
L
MR
P
H
HFQQQQRY
ND
YL
DNQ
R
FR
A
MNDLS
WGF
T
E
LTL
N
N
ELL
AQ
GKIMID
S
A
S
G
TL
PDGTVFS
I
P
DQ
D
A
LP
D
P
-
LH
P
QN
F
P
D
ER
S
RN
IYLALPV
A
S
D
V
R
NEI
-
---
S
DG
RR
IG
RY
--
R
LNYAD
VRD
L
H
SE
EGD
ART
L
T
LG
Q
L
T
PRI
M
S
--
GAED
MS
AYITLPL
C
RI
SD
RHA
D
GSLT
L
DD
D
FIP
SC
QN
IQ
VS
KK
L
RVY
L
K
EVQ
GA
I
GG
RA
S
DLA
N
--
RI
G
S
PAQ
SG
--
IADVAEFMMLQ
L
LNR
N
Q
TR
FTH
RA
R
RSQ
LHPE
DF
Y
L
DLA
E
LLGELMTF
T
E
P
-
S
RLPC
P
L
D
-------
V
Y
D
H
H
DL
TK
TF
-
K
TL
L
PEV
K
RAL
H
TVL
S
PRA
V
NL
P
L
HLRD
G
I
-
W
---
Q
A
D
V
HD
SE
LLQ
S
A
T
FVLAVAA
N
-
MP
V
DQIQ
R
QFIQQSKI
S
SPEKI
RN
MVSVQIPGI
P
L
RA
LM
V
APRQLP
Y
H
S
G
FS
YFELDK
SGQ
AW
TE
M
AA
AG
AV
ALH
V
SGSFPDLN
M
QLWAIRG
fig|444450.8.peg.366
Escherichia coli O157:H7 str. EC4115
MATTRNKVMW
Q
EG
M
L
MR
P
H
HFQQQQRY
ND
YL
DNQ
R
FR
A
MNDLS
WGF
T
E
LTL
N
N
ELL
AQ
GKIMID
S
A
S
G
TL
PDGTVFS
I
P
DQ
D
A
LP
D
P
-
LH
P
QN
F
P
D
ER
S
RN
IYLALPV
A
S
D
V
R
NEI
-
---
S
DG
RR
IG
RY
--
R
LNYAD
VRD
L
H
SE
EGD
ART
L
T
LG
Q
L
T
PRI
M
S
--
GAED
MS
AYITLPL
C
RI
SD
RHA
D
GSLT
L
DD
D
FIP
SC
QN
IQ
VS
KK
L
RVY
L
K
EVQ
GA
I
GG
RA
S
DLA
N
--
RI
G
S
PAQ
SG
--
IADVAEFMMLQ
L
LNR
N
Q
TR
FTH
RA
R
RSQ
LHPE
DF
Y
L
DLA
E
LLGELMTF
T
E
P
-
S
RLPC
P
L
D
-------
V
Y
D
H
H
DL
TK
TF
-
K
TL
L
PEV
K
RAL
H
TVL
S
PRA
V
NL
P
L
HLRD
G
I
-
W
---
Q
A
D
V
HD
SE
LLQ
S
A
T
FVLAVAA
N
-
MP
V
DQIQ
R
QFIQQSKI
S
SPEKI
RN
MVSVQIPGI
P
L
RA
LM
V
APRQLP
Y
H
S
G
FS
YFELDK
SGQ
AW
TE
M
AA
AG
AV
ALH
V
SGSFPDLN
M
QLWAIRG
fig|444451.5.peg.3690
Escherichia coli O157:H7 str. EC4196
MATTRNKVMW
Q
EG
M
L
MR
P
H
HFQQQQRY
ND
YL
DNQ
R
FR
A
MNDLS
WGF
T
E
LTL
N
N
ELL
AQ
GKIMID
S
A
S
G
TL
PDGTVFS
I
P
DQ
D
A
LP
D
P
-
LH
P
QN
F
P
D
ER
S
RN
IYLALPV
A
S
D
V
R
NEI
-
---
S
DG
RR
IG
RY
--
R
LNYAD
VRD
L
H
SE
EGD
ART
L
T
LG
Q
L
T
PRI
M
S
--
GAED
MS
AYITLPL
C
RI
SD
RHA
D
GSLT
L
DD
D
FIP
SC
QN
IQ
VS
KK
L
RVY
L
K
EVQ
GA
I
GG
RA
S
DLA
N
--
RI
G
S
PAQ
SG
--
IADVAEFMMLQ
L
LNR
N
Q
TR
FTH
RA
R
RSQ
LHPE
DF
Y
L
DLA
E
LLGELMTF
T
E
P
-
S
RLPC
P
L
D
-------
V
Y
D
H
H
DL
TK
TF
-
K
TL
L
PEV
K
RAL
H
TVL
S
PRA
V
NL
P
L
HLRD
G
I
-
W
---
Q
A
D
V
HD
SE
LLQ
S
A
T
FVLAVAA
N
-
MP
V
DQIQ
R
QFIQQSKI
S
SPEKI
RN
MVSVQIPGI
P
L
RA
LM
V
APRQLP
Y
H
S
G
FS
YFELDK
SGQ
AW
TE
M
AA
AG
AV
ALH
V
SGSFPDLN
M
QLWAIRG
fig|444447.5.peg.3073
Escherichia coli O157:H7 str. EC4206
MATTRNKVMW
Q
EG
M
L
MR
P
H
HFQQQQRY
ND
YL
DNQ
R
FR
A
MNDLS
WGF
T
E
LTL
N
N
ELL
AQ
GKIMID
S
A
S
G
TL
PDGTVFS
I
P
DQ
D
A
LP
D
P
-
LH
P
QN
F
P
D
ER
S
RN
IYLALPV
A
S
D
V
R
NEI
-
---
S
DG
RR
IG
RY
--
R
LNYAD
VRD
L
H
SE
EGD
ART
L
T
LG
Q
L
T
PRI
M
S
--
GAED
MS
AYITLPL
C
RI
SD
RHA
D
GSLT
L
DD
D
FIP
SC
QN
IQ
VS
KK
L
RVY
L
K
EVQ
GA
I
GG
RA
S
DLA
N
--
RI
G
S
PAQ
SG
--
IADVAEFMMLQ
L
LNR
N
Q
TR
FTH
RA
R
RSQ
LHPE
DF
Y
L
DLA
E
LLGELMTF
T
E
P
-
S
RLPC
P
L
D
-------
V
Y
D
H
H
DL
TK
TF
-
K
TL
L
PEV
K
RAL
H
TVL
S
PRA
V
NL
P
L
HLRD
G
I
-
W
---
Q
A
D
V
HD
SE
LLQ
S
A
T
FVLAVAA
N
-
MP
V
DQIQ
R
QFIQQSKI
S
SPEKI
RN
MVSVQIPGI
P
L
RA
LM
V
APRQLP
Y
H
S
G
FS
YFELDK
SGQ
AW
TE
M
AA
AG
AV
ALH
V
SGSFPDLN
M
QLWAIRG
fig|478004.5.peg.3898
Escherichia coli O157:H7 str. EC4401
MATTRNKVMW
Q
EG
M
L
MR
P
H
HFQQQQRY
ND
YL
DNQ
R
FR
A
MNDLS
WGF
T
E
LTL
N
N
ELL
AQ
GKIMID
S
A
S
G
TL
PDGTVFS
I
P
DQ
D
A
LP
D
P
-
LH
P
QN
F
P
D
ER
S
RN
IYLALPV
A
S
D
V
R
NEI
-
---
S
DG
RR
IG
RY
--
R
LNYAD
VRD
L
H
SE
EGD
ART
L
T
LG
Q
L
T
PRI
M
S
--
GAED
MS
AYITLPL
C
RI
SD
RHA
D
GSLT
L
DD
D
FIP
SC
QN
IQ
VS
KK
L
RVY
L
K
EVQ
GA
I
GG
RA
S
DLA
N
--
RI
G
S
PAQ
SG
--
IADVAEFMMLQ
L
LNR
N
Q
TR
FTH
RA
R
RSQ
LHPE
DF
Y
L
DLA
E
LLGELMTF
T
E
P
-
S
RLPC
P
L
D
-------
V
Y
D
H
H
DL
TK
TF
-
K
TL
L
PEV
K
RAL
H
TVL
S
PRA
V
NL
P
L
HLRD
G
I
-
W
---
Q
A
D
V
HD
SE
LLQ
S
A
T
FVLAVAA
N
-
MP
V
DQIQ
R
QFIQQSKI
S
SPEKI
RN
MVSVQIPGI
P
L
RA
LM
V
APRQLP
Y
H
S
G
FS
YFELDK
SGQ
AW
TE
M
AA
AG
AV
ALH
V
SGSFPDLN
M
QLWAIRG
fig|478005.5.peg.3830
Escherichia coli O157:H7 str. EC4486
MATTRNKVMW
Q
EG
M
L
MR
P
H
HFQQQQRY
ND
YL
DNQ
R
FR
A
MNDLS
WGF
T
E
LTL
N
N
ELL
AQ
GKIMID
S
A
S
G
TL
PDGTVFS
I
P
DQ
D
A
LP
D
P
-
LH
P
QN
F
P
D
ER
S
RN
IYLALPV
A
S
D
V
R
NEI
-
---
S
DG
RR
IG
RY
--
R
LNYAD
VRD
L
H
SE
EGD
ART
L
T
LG
Q
L
T
PRI
M
S
--
GAED
MS
AYITLPL
C
RI
SD
RHA
D
GSLT
L
DD
D
FIP
SC
QN
IQ
VS
KK
L
RVY
L
K
EVQ
GA
I
GG
RA
S
DLA
N
--
RI
G
S
PAQ
SG
--
IADVAEFMMLQ
L
LNR
N
Q
TR
FTH
RA
R
RSQ
LHPE
DF
Y
L
DLA
E
LLGELMTF
T
E
P
-
S
RLPC
P
L
D
-------
V
Y
D
H
H
DL
TK
TF
-
K
TL
L
PEV
K
RAL
H
TVL
S
PRA
V
NL
P
L
HLRD
G
I
-
W
---
Q
A
D
V
HD
SE
LLQ
S
A
T
FVLAVAA
N
-
MP
V
DQIQ
R
QFIQQSKI
S
SPEKI
RN
MVSVQIPGI
P
L
RA
LM
V
APRQLP
Y
H
S
G
FS
YFELDK
SGQ
AW
TE
M
AA
AG
AV
ALH
V
SGSFPDLN
M
QLWAIRG
fig|478006.5.peg.3833
Escherichia coli O157:H7 str. EC4501
MATTRNKVMW
Q
EG
M
L
MR
P
H
HFQQQQRY
ND
YL
DNQ
R
FR
A
MNDLS
WGF
T
E
LTL
N
N
ELL
AQ
GKIMID
S
A
S
G
TL
PDGTVFS
I
P
DQ
D
A
LP
D
P
-
LH
P
QN
F
P
D
ER
S
RN
IYLALPV
A
S
D
V
R
NEI
-
---
S
DG
RR
IG
RY
--
R
LNYAD
VRD
L
H
SE
EGD
ART
L
T
LG
Q
L
T
PRI
M
S
--
GAED
MS
AYITLPL
C
RI
SD
RHA
D
GSLT
L
DD
D
FIP
SC
QN
IQ
VS
KK
L
RVY
L
K
EVQ
GA
I
GG
RA
S
DLA
N
--
RI
G
S
PAQ
SG
--
IADVAEFMMLQ
L
LNR
N
Q
TR
FTH
RA
R
RSQ
LHPE
DF
Y
L
DLA
E
LLGELMTF
T
E
P
-
S
RLPC
P
L
D
-------
V
Y
D
H
H
DL
TK
TF
-
K
TL
L
PEV
K
RAL
H
TVL
S
PRA
V
NL
P
L
HLRD
G
I
-
W
---
Q
A
D
V
HD
SE
LLQ
S
A
T
FVLAVAA
N
-
MP
V
DQIQ
R
QFIQQSKI
S
SPEKI
RN
MVSVQIPGI
P
L
RA
LM
V
APRQLP
Y
H
S
G
FS
YFELDK
SGQ
AW
TE
M
AA
AG
AV
ALH
V
SGSFPDLN
M
QLWAIRG
fig|478007.5.peg.3056
Escherichia coli O157:H7 str. EC508
MATTRNKVMW
Q
EG
M
L
MR
P
H
HFQQQQRY
ND
YL
DNQ
R
FR
A
MNDLS
WGF
T
E
LTL
N
N
ELL
AQ
GKIMID
S
A
S
G
TL
PDGTVFS
I
P
DQ
D
A
LP
D
P
-
LH
P
QN
F
P
D
ER
S
RN
IYLALPV
A
S
D
V
R
NEI
-
---
S
DG
RR
IG
RY
--
R
LNYAD
VRD
L
H
SE
EGD
ART
L
T
LG
Q
L
T
PRI
M
S
--
GAED
MS
AYITLPL
C
RI
SD
RHA
D
GSLT
L
DD
D
FIP
SC
QN
IQ
VS
KK
L
RVY
L
K
EVQ
GA
I
GG
RA
S
DLA
N
--
RI
G
S
PAQ
SG
--
IADVAEFMMLQ
L
LNR
N
Q
TR
FTH
RA
R
RSQ
LHPE
DF
Y
L
DLA
E
LLGELMTF
T
E
P
-
S
RLPC
P
L
D
-------
V
Y
D
H
H
DL
TK
TF
-
K
TL
L
PEV
K
RAL
H
TVL
S
PRA
V
NL
P
L
HLRD
G
I
-
W
---
Q
A
D
V
HD
SE
LLQ
S
A
T
FVLAVAA
N
-
MP
V
DQIQ
R
QFIQQSKI
S
SPEKI
RN
MVSVQIPGI
P
L
RA
LM
V
APRQLP
Y
H
S
G
FS
YFELDK
SGQ
AW
TE
M
AA
AG
AV
ALH
V
SGSFPDLN
M
QLWAIRG
fig|386585.9.peg.326
Escherichia coli O157:H7 str. Sakai
MATTRNKVMW
Q
EG
M
L
MR
P
H
HFQQQQRY
ND
YL
DNQ
R
FR
A
MNDLS
WGF
T
E
LTL
N
N
ELL
AQ
GKIMID
S
A
S
G
TL
PDGTVFS
I
P
DQ
D
A
LP
D
P
-
LH
P
QN
F
P
D
ER
S
RN
IYLALPV
A
S
D
V
R
NEI
-
---
S
DG
RR
IG
RY
--
R
LNYAD
VRD
L
H
SE
EGD
ART
L
T
LG
Q
L
T
PRI
M
S
--
GAED
MS
AYITLPL
C
RI
SD
RHA
D
GSLT
L
DD
D
FIP
SC
QN
IQ
VS
KK
L
RVY
L
K
EVQ
GA
I
GG
RA
S
DLA
N
--
RI
G
S
PAQ
SG
--
IADVAEFMMLQ
L
LNR
N
Q
TR
FTH
RA
R
RSQ
LHPE
DF
Y
L
DLA
E
LLGELMTF
T
E
P
-
S
RLPC
P
L
D
-------
V
Y
D
H
H
DL
TK
TF
-
K
TL
L
PEV
K
RAL
H
TVL
S
PRA
V
NL
P
L
HLRD
G
I
-
W
---
Q
A
D
V
HD
SE
LLQ
S
A
T
FVLAVAA
N
-
MP
V
DQIQ
R
QFIQQSKI
S
SPEKI
RN
MVSVQIPGI
P
L
RA
LM
V
APRQLP
Y
H
S
G
FS
YFELDK
SGQ
AW
TE
M
AA
AG
AV
ALH
V
SGSFPDLN
M
QLWAIRG
fig|544404.4.peg.228
Escherichia coli O157:H7 str. TW14359
MATTRNKVMW
Q
EG
M
L
MR
P
H
HFQQQQRY
ND
YL
DNQ
R
FR
A
MNDLS
WGF
T
E
LTL
N
N
ELL
AQ
GKIMID
S
A
S
G
TL
PDGTVFS
I
P
DQ
D
A
LP
D
P
-
LH
P
QN
F
P
D
ER
S
RN
IYLALPV
A
S
D
V
R
NEI
-
---
S
DG
RR
IG
RY
--
R
LNYAD
VRD
L
H
SE
EGD
ART
L
T
LG
Q
L
T
PRI
M
S
--
GAED
MS
AYITLPL
C
RI
SD
RHA
D
GSLT
L
DD
D
FIP
SC
QN
IQ
VS
KK
L
RVY
L
K
EVQ
GA
I
GG
RA
S
DLA
N
--
RI
G
S
PAQ
SG
--
IADVAEFMMLQ
L
LNR
N
Q
TR
FTH
RA
R
RSQ
LHPE
DF
Y
L
DLA
E
LLGELMTF
T
E
P
-
S
RLPC
P
L
D
-------
V
Y
D
H
H
DL
TK
TF
-
K
TL
L
PEV
K
RAL
H
TVL
S
PRA
V
NL
P
L
HLRD
G
I
-
W
---
Q
A
D
V
HD
SE
LLQ
S
A
T
FVLAVAA
N
-
MP
V
DQIQ
R
QFIQQSKI
S
SPEKI
RN
MVSVQIPGI
P
L
RA
LM
V
APRQLP
Y
H
S
G
FS
YFELDK
SGQ
AW
TE
M
AA
AG
AV
ALH
V
SGSFPDLN
M
QLWAIRG
fig|502346.5.peg.1037
Escherichia coli O157:H7 str. TW14588
MATTRNKVMW
Q
EG
M
L
MR
P
H
HFQQQQRY
ND
YL
DNQ
R
FR
A
MNDLS
WGF
T
E
LTL
N
N
ELL
AQ
GKIMID
S
A
S
G
TL
PDGTVFS
I
P
DQ
D
A
LP
D
P
-
LH
P
QN
F
P
D
ER
S
RN
IYLALPV
A
S
D
V
R
NEI
-
---
S
DG
RR
IG
RY
--
R
LNYAD
VRD
L
H
SE
EGD
ART
L
T
LG
Q
L
T
PRI
M
S
--
GAED
MS
AYITLPL
C
RI
SD
RHA
D
GSLT
L
DD
D
FIP
SC
QN
IQ
VS
KK
L
RVY
L
K
EVQ
GA
I
GG
RA
S
DLA
N
--
RI
G
S
PAQ
SG
--
IADVAEFMMLQ
L
LNR
N
Q
TR
FTH
RA
R
RSQ
LHPE
DF
Y
L
DLA
E
LLGELMTF
T
E
P
-
S
RLPC
P
L
D
-------
V
Y
D
H
H
DL
TK
TF
-
K
TL
L
PEV
K
RAL
H
TVL
S
PRA
V
NL
P
L
HLRD
G
I
-
W
---
Q
A
D
V
HD
SE
LLQ
S
A
T
FVLAVAA
N
-
MP
V
DQIQ
R
QFIQQSKI
S
SPEKI
RN
MVSVQIPGI
P
L
RA
LM
V
APRQLP
Y
H
S
G
FS
YFELDK
SGQ
AW
TE
M
AA
AG
AV
ALH
V
SGSFPDLN
M
QLWAIRG
fig|585395.4.peg.226
Escherichia coli O103:H2 str. 12009
MATTRNKVMW
Q
EG
M
L
MR
P
H
HFQQQQRY
ND
YL
DNQ
R
FR
A
MNDLS
WGF
T
E
LTL
N
N
ELL
AQ
GKIMID
S
A
S
G
TL
L
DGTVFS
I
P
DQ
D
A
LP
D
P
-
LH
P
QN
F
P
D
ER
S
RN
IYLALPV
A
S
D
V
R
NEI
-
---
S
DG
RR
IG
RY
--
R
LNYAD
VRD
L
H
SE
EGD
ART
L
T
LG
Q
L
T
PRI
M
S
--
GAED
MS
AYITLPL
C
RI
SD
RHA
D
GSLT
L
DD
D
FIP
SC
QN
IQ
VS
KK
L
RVY
L
K
EVQ
GA
I
GG
RA
S
DLA
N
--
RI
G
S
PAQ
SG
--
IADVAEFMMLQ
L
LNR
N
Q
TR
FTH
RA
R
RSQ
LHPE
DF
Y
L
DLA
G
LLGELMTF
T
E
P
-
S
RLPC
P
L
D
-------
V
Y
D
H
H
DL
TK
TF
-
K
TL
L
PEV
K
RAL
H
TVL
S
PRA
V
NL
P
L
HLRD
G
I
-
W
---
Q
A
D
IHD
TE
LLQ
S
A
T
FVLAVAA
N
-
V
P
V
DQIQ
R
QFIQQSKI
S
SPEKI
RN
MVSVQIPGI
P
L
RA
LM
V
APRQLP
Y
H
S
G
FS
YFELDK
SGQ
AW
TE
M
AA
AG
AV
ALH
V
SGSFPDLN
M
QLWAIRG
fig|550676.3.peg.21
Escherichia coli B185
MATTRNKVMW
Q
EG
M
L
MR
P
H
HFQQQQRY
ND
YL
DNQ
R
FR
A
MNDLS
WGF
T
E
LTL
N
N
ELL
AQ
GKIMID
S
A
S
G
TL
PDGTVFS
I
P
DQ
D
A
LP
D
P
-
LH
P
QN
F
P
D
ER
S
RN
IYLALPV
A
S
D
V
R
NEI
-
---
S
DG
RR
IG
RY
--
R
LNYAD
VRD
L
H
SE
EGD
ART
L
T
LG
Q
L
T
PRI
M
S
--
GAED
MS
AYITLPL
C
RI
SD
RHA
D
GSLT
L
DD
D
FIP
SW
QN
IQ
VS
KK
L
RVY
L
K
EVQ
GA
I
GG
RA
S
DLA
N
--
RI
G
S
PAQ
SG
--
IADVAEFMMLQ
L
LNR
N
Q
TR
FTH
RA
R
RSQ
LHPE
DF
Y
L
DLA
G
LLGELMTF
T
E
P
-
S
RLPC
P
L
D
-------
V
Y
D
H
H
DL
TK
TF
-
K
TL
L
PEV
K
RAL
H
TVL
S
PRA
V
NL
P
L
HLRD
G
I
-
W
---
Q
A
D
V
HD
SE
LLQ
S
A
T
FVLAVAA
N
-
MP
V
DQIQ
R
QFIQQSKI
S
SPEKI
RN
MVSVQIPGI
P
L
RA
LM
V
APRQLP
Y
H
S
G
FS
YFELDK
SGQ
AW
TE
M
AA
AG
AV
ALH
V
SGSFPDLN
M
QLWAIRG
fig|478008.5.peg.4726
Escherichia coli O157:H7 str. EC869
MATTRNKVMW
Q
EG
M
L
MR
P
H
HFQQQQRY
ND
YL
DNQ
R
FR
A
MNDLS
WGF
T
E
LTL
N
N
ELL
AQ
GKIMID
S
A
S
G
TL
PDGTVFS
I
P
DQ
D
A
LP
D
P
-
LH
P
QN
F
P
D
ER
S
RN
IYLALPV
A
S
D
V
R
NEI
-
---
S
DG
RR
IG
RY
--
R
LNYAD
VRD
L
H
SE
EGD
ART
L
T
LG
Q
L
T
PRI
M
S
--
GAED
MS
AYITLPL
C
RI
SD
RHA
D
GSLT
L
DD
D
FIP
SC
QN
IQ
VS
KK
L
RVY
L
K
EVQ
GA
I
GG
RA
S
DLA
N
--
RI
G
S
PAQ
SG
--
IADVAEFMMLQ
L
LNR
N
Q
TR
FTH
RA
R
RSQ
LHPE
DF
Y
L
DLA
E
LLGELMTF
T
E
P
-
S
RL
L
C
P
L
D
-------
V
Y
D
H
H
DL
TK
TF
-
K
TL
L
PEV
K
RAL
H
TVL
S
PRA
V
NL
P
L
HLRD
G
I
-
W
---
Q
A
D
V
HD
SE
LLQ
S
A
T
FVLAVAA
N
-
MP
V
DQIQ
R
QFIQQSKI
S
SPEKI
RN
MVSVQIPGI
P
L
RA
LM
V
APRQLP
Y
H
S
G
FS
YFELDK
SGQ
AW
TE
M
AA
AG
AV
ALH
V
SGSFPDLN
M
QLWAIRG
fig|637388.3.peg.793
Escherichia coli O157:H7 str. FRIK2000
MATTRNKVMW
Q
EG
M
L
MR
P
H
HFQQQQRY
ND
YL
DNQ
R
FR
A
MNDLS
WGF
T
E
LTL
N
N
ELL
AQ
GKIMID
S
A
S
G
TL
PDGTVFS
I
P
DQ
D
A
LP
D
P
-
LH
P
QN
F
P
D
ER
S
RN
IYLALPV
A
S
D
V
R
NEI
-
---
S
DG
RR
IG
RY
--
R
LNYAD
VRD
L
H
SE
EGD
ART
L
T
LG
Q
L
T
PRI
M
S
--
GAED
MS
AYITLPL
C
RI
SD
RHA
D
GSLT
L
DD
D
FIP
SC
QN
IQ
VS
KK
L
RVY
L
K
EVQ
GA
I
GG
RA
S
DLA
N
--
RI
G
S
PAQ
SG
--
IADVAEFMMLQ
L
LNR
N
Q
TR
FTH
RA
R
RSQ
LHPE
DF
Y
L
DLA
E
LLGELMTF
T
E
P
-
S
RL
L
C
P
L
D
-------
V
Y
D
H
H
DL
TK
TF
-
K
TL
L
PEV
K
RAL
H
TVL
S
PRA
V
NL
P
L
HLRD
G
I
-
W
---
Q
A
D
V
HD
SE
LLQ
S
A
T
FVLAVAA
N
-
MP
V
DQIQ
R
QFIQQSKI
S
SPEKI
RN
MVSVQIPGI
P
L
RA
LM
V
APRQLP
Y
H
S
G
FS
YFELDK
SGQ
AW
TE
M
AA
AG
AV
ALH
V
SGSFPDLN
M
QLWAIRG
fig|570506.3.peg.1702
Escherichia coli O157:H7 str. FRIK966
MATTRNKVMW
Q
EG
M
L
MR
P
H
HFQQQQRY
ND
YL
DNQ
R
FR
A
MNDLS
WGF
T
E
LTL
N
N
ELL
AQ
GKIMID
S
A
S
G
TL
PDGTVFS
I
P
DQ
D
A
LP
D
P
-
LH
P
QN
F
P
D
ER
S
RN
IYLALPV
A
S
D
V
R
NEI
-
---
S
DG
RR
IG
RY
--
R
LNYAD
VRD
L
H
SE
EGD
ART
L
T
LG
Q
L
T
PRI
M
S
--
GAED
MS
AYITLPL
C
RI
SD
RHA
D
GSLT
L
DD
D
FIP
SC
QN
IQ
VS
KK
L
RVY
L
K
EVQ
GA
I
GG
RA
S
DLA
N
--
RI
G
S
PAQ
SG
--
IADVAEFMMLQ
L
LNR
N
Q
TR
FTH
RA
R
RSQ
LHPE
DF
Y
L
DLA
E
LLGELMTF
T
E
P
-
S
RL
L
C
P
L
D
-------
V
Y
D
H
H
DL
TK
TF
-
K
TL
L
PEV
K
RAL
H
TVL
S
PRA
V
NL
P
L
HLRD
G
I
-
W
---
Q
A
D
V
HD
SE
LLQ
S
A
T
FVLAVAA
N
-
MP
V
DQIQ
R
QFIQQSKI
S
SPEKI
RN
MVSVQIPGI
P
L
RA
LM
V
APRQLP
Y
H
S
G
FS
YFELDK
SGQ
AW
TE
M
AA
AG
AV
ALH
V
SGSFPDLN
M
QLWAIRG
fig|405955.13.peg.231
Escherichia coli APEC O1
MAT
MK
NKV
I
W
Q
EG
L
F
AL
PQHFQQQQR
H
CE
YL
LTR
R
LD
A
LGDFF
WGF
T
E
LSI
N
T
ELL
AQ
GKIMID
R
A
A
G
CM
PDGTVFS
I
P
DQ
D
L
LP
E
P
-
FQ
P
GT
L
S
S
KE
S
HN
IYLALPV
I
S
D
V
I
NEI
Q
GLH
S
AG
Q
G
TE
RY
--
R
LTHTR
VRD
F
H
TD
EGD
EQP
V
G
LG
Q
L
I
PRI
V
S
--
GA
D
D
LS
A
MV
TLPL
C
RI
LN
K
N
A
T
G
A
L
V
L
D
N
T
FIP
TI
Q
A
VR
VS
GL
L
GAF
S
G
EVQ
GL
L
AT
RA
A
DLA
G
--
RI
G
S
PEQ
SG
--
IADVAEFMMLQ
M
LNR
Y
Q
MQ
FTH
RS
Q
LHT
LHPE
AF
Y
R
DL
V
G
LLGELMTF
T
E
G
-
N
RLPC
T
V
E
-------
P
Y
N
H
R
DL
TA
TF
T
R
T
V
I
PE
L
R
RAL
N
TVL
V
PRA
Q
NL
P
L
FFSE
G
T
-
W
---
I
A
T
I
N
D
PT
LLQ
S
C
K
L
VLAV
R
A
R
-
MP
Y
DQ
V
Q
R
QFIQQSK
V
A
ATD
KI
RS
V
VSVQ
V
PGI
P
L
HT
L
T
A
APRQLP
Y
H
E
G
YV
YFEL
E
K
GTP
AW
QD
V
IK
AG
AL
ALH
I
SGSFPDLN
L
QLWAIRG
fig|405955.9.peg.199
Escherichia coli APEC O1
MAT
MK
NKV
I
W
Q
EG
L
F
AL
PQHFQQQQR
H
CE
YL
LTR
R
LD
A
LGDFF
WGF
T
E
LSI
N
T
ELL
AQ
GKIMID
R
A
A
G
CM
PDGTVFS
I
P
DQ
D
L
LP
E
P
-
FQ
P
GT
L
S
S
KE
S
HN
IYLALPV
I
S
D
V
I
NEI
Q
GLH
S
AG
Q
G
TE
RY
--
R
LTHTR
VRD
F
H
TD
EGD
EQP
V
G
LG
Q
L
I
PRI
V
S
--
GA
D
D
LS
A
MV
TLPL
C
RI
LN
K
N
A
T
G
A
L
V
L
D
N
T
FIP
TI
Q
A
VR
VS
GL
L
GAF
S
G
EVQ
GL
L
AT
RA
A
DLA
G
--
RI
G
S
PEQ
SG
--
IADVAEFMMLQ
M
LNR
Y
Q
MQ
FTH
RS
Q
LHT
LHPE
AF
Y
R
DL
V
G
LLGELMTF
T
E
G
-
N
RLPC
T
V
E
-------
P
Y
N
H
R
DL
TA
TF
T
R
T
V
I
PE
L
R
RAL
N
TVL
V
PRA
Q
NL
P
L
FFSE
G
T
-
W
---
I
A
T
I
N
D
PT
LLQ
S
C
K
L
VLAV
R
A
R
-
MP
Y
DQ
V
Q
R
QFIQQSK
V
A
ATD
KI
RS
V
VSVQ
V
PGI
P
L
HT
L
T
A
APRQLP
Y
H
E
G
YV
YFEL
E
K
GTP
AW
QD
V
IK
AG
AL
ALH
I
SGSFPDLN
L
QLWAIRG
fig|585397.7.peg.231
Escherichia coli ED1a
MAT
MK
NKV
I
W
Q
EG
L
F
AL
PQHFQQQQR
H
CE
YL
LTR
R
LD
A
LGDFF
WGF
T
E
LSI
N
T
ELL
AQ
GKIMID
R
A
A
G
CM
PDGTVFS
I
P
DQ
D
L
LP
E
P
-
FQ
P
GT
L
S
S
KE
S
HN
IYLALPV
I
S
D
V
I
NEI
Q
GLH
S
AG
Q
G
TE
RY
--
R
LTHTR
VRD
F
H
TD
EGD
EQP
V
G
LG
Q
L
I
PRI
V
S
--
GA
D
D
LS
A
MV
TLPL
C
RI
LN
K
N
A
T
G
A
L
V
L
D
N
T
FIP
TI
Q
A
VR
VS
GL
L
GAF
S
G
EVQ
GL
L
AT
RA
A
DLA
G
--
RI
G
S
PEQ
SG
--
IADVAEFMMLQ
M
LNR
Y
Q
MQ
FTH
RS
Q
LHT
LHPE
AF
Y
R
DL
V
G
LLGELMTF
T
E
G
-
N
RLPC
T
V
E
-------
P
Y
N
H
R
DL
TA
TF
T
R
T
V
I
PE
L
R
RAL
N
TVL
V
PRA
Q
NL
P
L
FFSE
G
T
-
W
---
I
A
T
I
N
D
PT
LLQ
S
C
K
L
VLAV
R
A
R
-
MP
Y
DQ
V
Q
R
QFIQQSK
V
A
ATD
KI
RS
V
VSVQ
V
PGI
P
L
HT
L
T
A
APRQLP
Y
H
E
G
YV
YFEL
E
K
GTP
AW
QD
V
IK
AG
AL
ALH
I
SGSFPDLN
L
QLWAIRG
fig|585397.9.peg.231
Escherichia coli ED1a
MAT
MK
NKV
I
W
Q
EG
L
F
AL
PQHFQQQQR
H
CE
YL
LTR
R
LD
A
LGDFF
WGF
T
E
LSI
N
T
ELL
AQ
GKIMID
R
A
A
G
CM
PDGTVFS
I
P
DQ
D
L
LP
E
P
-
FQ
P
GT
L
S
S
KE
S
HN
IYLALPV
I
S
D
V
I
NEI
Q
GLH
S
AG
Q
G
TE
RY
--
R
LTHTR
VRD
F
H
TD
EGD
EQP
V
G
LG
Q
L
I
PRI
V
S
--
GA
D
D
LS
A
MV
TLPL
C
RI
LN
K
N
A
T
G
A
L
V
L
D
N
T
FIP
TI
Q
A
VR
VS
GL
L
GAF
S
G
EVQ
GL
L
AT
RA
A
DLA
G
--
RI
G
S
PEQ
SG
--
IADVAEFMMLQ
M
LNR
Y
Q
MQ
FTH
RS
Q
LHT
LHPE
AF
Y
R
DL
V
G
LLGELMTF
T
E
G
-
N
RLPC
T
V
E
-------
P
Y
N
H
R
DL
TA
TF
T
R
T
V
I
PE
L
R
RAL
N
TVL
V
PRA
Q
NL
P
L
FFSE
G
T
-
W
---
I
A
T
I
N
D
PT
LLQ
S
C
K
L
VLAV
R
A
R
-
MP
Y
DQ
V
Q
R
QFIQQSK
V
A
ATD
KI
RS
V
VSVQ
V
PGI
P
L
HT
L
T
A
APRQLP
Y
H
E
G
YV
YFEL
E
K
GTP
AW
QD
V
IK
AG
AL
ALH
I
SGSFPDLN
L
QLWAIRG
fig|714962.3.peg.229
Escherichia coli IHE3034
MAT
MK
NKV
I
W
Q
EG
L
F
AL
PQHFQQQQR
H
CE
YL
LTR
R
LD
A
LGDFF
WGF
T
E
LSI
N
T
ELL
AQ
GKIMID
R
A
A
G
CM
PDGTVFS
I
P
DQ
D
L
LP
E
P
-
FQ
P
GT
L
S
S
KE
S
HN
IYLALPV
I
S
D
V
I
NEI
Q
GLH
S
AG
Q
G
TE
RY
--
R
LTHTR
VRD
F
H
TD
EGD
EQP
V
G
LG
Q
L
I
PRI
V
S
--
GA
D
D
LS
A
MV
TLPL
C
RI
LN
K
N
A
T
G
A
L
V
L
D
N
T
FIP
TI
Q
A
VR
VS
GL
L
GAF
S
G
EVQ
GL
L
AT
RA
A
DLA
G
--
RI
G
S
PEQ
SG
--
IADVAEFMMLQ
M
LNR
Y
Q
MQ
FTH
RS
Q
LHT
LHPE
AF
Y
R
DL
V
G
LLGELMTF
T
E
G
-
N
RLPC
T
V
E
-------
P
Y
N
H
R
DL
TA
TF
T
R
T
V
I
PE
L
R
RAL
N
TVL
V
PRA
Q
NL
P
L
FFSE
G
T
-
W
---
I
A
T
I
N
D
PT
LLQ
S
C
K
L
VLAV
R
A
R
-
MP
Y
DQ
V
Q
R
QFIQQSK
V
A
ATD
KI
RS
V
VSVQ
V
PGI
P
L
HT
L
T
A
APRQLP
Y
H
E
G
YV
YFEL
E
K
GTP
AW
QD
V
IK
AG
AL
ALH
I
SGSFPDLN
L
QLWAIRG
fig|585035.6.peg.232
Escherichia coli S88
MAT
MK
NKV
I
W
Q
EG
L
F
AL
PQHFQQQQR
H
CE
YL
LTR
R
LD
A
LGDFF
WGF
T
E
LSI
N
T
ELL
AQ
GKIMID
R
A
A
G
CM
PDGTVFS
I
P
DQ
D
L
LP
E
P
-
FQ
P
GT
L
S
S
KE
S
HN
IYLALPV
I
S
D
V
I
NEI
Q
GLH
S
AG
Q
G
TE
RY
--
R
LTHTR
VRD
F
H
TD
EGD
EQP
V
G
LG
Q
L
I
PRI
V
S
--
GA
D
D
LS
A
MV
TLPL
C
RI
LN
K
N
A
T
G
A
L
V
L
D
N
T
FIP
TI
Q
A
VR
VS
GL
L
GAF
S
G
EVQ
GL
L
AT
RA
A
DLA
G
--
RI
G
S
PEQ
SG
--
IADVAEFMMLQ
M
LNR
Y
Q
MQ
FTH
RS
Q
LHT
LHPE
AF
Y
R
DL
V
G
LLGELMTF
T
E
G
-
N
RLPC
T
V
E
-------
P
Y
N
H
R
DL
TA
TF
T
R
T
V
I
PE
L
R
RAL
N
TVL
V
PRA
Q
NL
P
L
FFSE
G
T
-
W
---
I
A
T
I
N
D
PT
LLQ
S
C
K
L
VLAV
R
A
R
-
MP
Y
DQ
V
Q
R
QFIQQSK
V
A
ATD
KI
RS
V
VSVQ
V
PGI
P
L
HT
L
T
A
APRQLP
Y
H
E
G
YV
YFEL
E
K
GTP
AW
QD
V
IK
AG
AL
ALH
I
SGSFPDLN
L
QLWAIRG
fig|869729.3.peg.3466
Escherichia coli UM146
MAT
MK
NKV
I
W
Q
EG
L
F
AL
PQHFQQQQR
H
CE
YL
LTR
R
LD
A
LGDFF
WGF
T
E
LSI
N
T
ELL
AQ
GKIMID
R
A
A
G
CM
PDGTVFS
I
P
DQ
D
L
LP
E
P
-
FQ
P
GT
L
S
S
KE
S
HN
IYLALPV
I
S
D
V
I
NEI
Q
GLH
S
AG
Q
G
TE
RY
--
R
LTHTR
VRD
F
H
TD
EGD
EQP
V
G
LG
Q
L
I
PRI
V
S
--
GA
D
D
LS
A
MV
TLPL
C
RI
LN
K
N
A
T
G
A
L
V
L
D
N
T
FIP
TI
Q
A
VR
VS
GL
L
GAF
S
G
EVQ
GL
L
AT
RA
A
DLA
G
--
RI
G
S
PEQ
SG
--
IADVAEFMMLQ
M
LNR
Y
Q
MQ
FTH
RS
Q
LHT
LHPE
AF
Y
R
DL
V
G
LLGELMTF
T
E
G
-
N
RLPC
T
V
E
-------
P
Y
N
H
R
DL
TA
TF
T
R
T
V
I
PE
L
R
RAL
N
TVL
V
PRA
Q
NL
P
L
FFSE
G
T
-
W
---
I
A
T
I
N
D
PT
LLQ
S
C
K
L
VLAV
R
A
R
-
MP
Y
DQ
V
Q
R
QFIQQSK
V
A
ATD
KI
RS
V
VSVQ
V
PGI
P
L
HT
L
T
A
APRQLP
Y
H
E
G
YV
YFEL
E
K
GTP
AW
QD
V
IK
AG
AL
ALH
I
SGSFPDLN
L
QLWAIRG
fig|364106.7.peg.363
Escherichia coli UTI89
MAT
MK
NKV
I
W
Q
EG
L
F
AL
PQHFQQQQR
H
CE
YL
LTR
R
LD
A
LGDFF
WGF
T
E
LSI
N
T
ELL
AQ
GKIMID
R
A
A
G
CM
PDGTVFS
I
P
DQ
D
L
LP
E
P
-
FQ
P
GT
L
S
S
KE
S
HN
IYLALPV
I
S
D
V
I
NEI
Q
GLH
S
AG
Q
G
TE
RY
--
R
LTHTR
VRD
F
H
TD
EGD
EQP
V
G
LG
Q
L
I
PRI
V
S
--
GA
D
D
LS
A
MV
TLPL
C
RI
LN
K
N
A
T
G
A
L
V
L
D
N
T
FIP
TI
Q
A
VR
VS
GL
L
GAF
S
G
EVQ
GL
L
AT
RA
A
DLA
G
--
RI
G
S
PEQ
SG
--
IADVAEFMMLQ
M
LNR
Y
Q
MQ
FTH
RS
Q
LHT
LHPE
AF
Y
R
DL
V
G
LLGELMTF
T
E
G
-
N
RLPC
T
V
E
-------
P
Y
N
H
R
DL
TA
TF
T
R
T
V
I
PE
L
R
RAL
N
TVL
V
PRA
Q
NL
P
L
FFSE
G
T
-
W
---
I
A
T
I
N
D
PT
LLQ
S
C
K
L
VLAV
R
A
R
-
MP
Y
DQ
V
Q
R
QFIQQSK
V
A
ATD
KI
RS
V
VSVQ
V
PGI
P
L
HT
L
T
A
APRQLP
Y
H
E
G
YV
YFEL
E
K
GTP
AW
QD
V
IK
AG
AL
ALH
I
SGSFPDLN
L
QLWAIRG
fig|364106.8.peg.361
Escherichia coli UTI89
MAT
MK
NKV
I
W
Q
EG
L
F
AL
PQHFQQQQR
H
CE
YL
LTR
R
LD
A
LGDFF
WGF
T
E
LSI
N
T
ELL
AQ
GKIMID
R
A
A
G
CM
PDGTVFS
I
P
DQ
D
L
LP
E
P
-
FQ
P
GT
L
S
S
KE
S
HN
IYLALPV
I
S
D
V
I
NEI
Q
GLH
S
AG
Q
G
TE
RY
--
R
LTHTR
VRD
F
H
TD
EGD
EQP
V
G
LG
Q
L
I
PRI
V
S
--
GA
D
D
LS
A
MV
TLPL
C
RI
LN
K
N
A
T
G
A
L
V
L
D
N
T
FIP
TI
Q
A
VR
VS
GL
L
GAF
S
G
EVQ
GL
L
AT
RA
A
DLA
G
--
RI
G
S
PEQ
SG
--
IADVAEFMMLQ
M
LNR
Y
Q
MQ
FTH
RS
Q
LHT
LHPE
AF
Y
R
DL
V
G
LLGELMTF
T
E
G
-
N
RLPC
T
V
E
-------
P
Y
N
H
R
DL
TA
TF
T
R
T
V
I
PE
L
R
RAL
N
TVL
V
PRA
Q
NL
P
L
FFSE
G
T
-
W
---
I
A
T
I
N
D
PT
LLQ
S
C
K
L
VLAV
R
A
R
-
MP
Y
DQ
V
Q
R
QFIQQSK
V
A
ATD
KI
RS
V
VSVQ
V
PGI
P
L
HT
L
T
A
APRQLP
Y
H
E
G
YV
YFEL
E
K
GTP
AW
QD
V
IK
AG
AL
ALH
I
SGSFPDLN
L
QLWAIRG
fig|216592.1.peg.5064
Escherichia coli 042
MAT
MK
NKV
I
W
Q
EG
L
F
AL
PQHFQQQQR
H
CE
YL
LNR
R
LD
A
LGDFF
WGF
T
E
LSI
N
T
ELL
AQ
GKIMID
R
A
A
G
CM
PDGTVFS
I
P
DQ
D
L
LP
E
P
-
FQ
P
GT
L
S
S
KE
S
HN
IYLALPV
I
S
D
V
I
NEI
Q
GLH
S
AG
Q
G
TE
RY
--
R
LTHTR
VRD
F
H
TD
EGD
EQP
V
G
LG
Q
L
I
PRI
V
S
--
GA
D
D
LS
A
MV
TLPL
C
RI
LN
K
N
A
T
G
A
L
V
L
D
N
T
FIP
TI
Q
A
VR
VS
GL
L
GAF
S
G
EVQ
GL
L
AT
RA
A
DLA
G
--
RI
G
S
PEQ
SG
--
IADVAEFMMLQ
M
LNR
H
Q
MQ
FTH
RS
Q
LHT
LHPE
AF
Y
Q
DL
V
G
LLGELMTF
T
E
G
-
N
RLPC
T
V
E
-------
P
Y
N
H
R
DL
TA
TF
T
R
T
V
I
PE
L
R
RAL
N
TVL
V
PRA
Q
NL
P
L
FFSE
G
T
-
W
---
I
A
T
I
S
D
PT
LLQ
S
C
K
L
VLAV
R
A
R
-
MP
Y
DQ
V
Q
R
QFIQQSK
V
A
ATD
KI
RS
V
VSVQ
V
PGI
P
L
HT
L
T
A
APRQLP
W
H
E
G
YV
YFEL
E
K
GTP
AW
QD
V
IK
AG
AL
ALH
I
SG
T
FPDLN
L
QLWAIRG
fig|216592.3.peg.230
Escherichia coli 042
MAT
MK
NKV
I
W
Q
EG
L
F
AL
PQHFQQQQR
H
CE
YL
LNR
R
LD
A
LGDFF
WGF
T
E
LSI
N
T
ELL
AQ
GKIMID
R
A
A
G
CM
PDGTVFS
I
P
DQ
D
L
LP
E
P
-
FQ
P
GT
L
S
S
KE
S
HN
IYLALPV
I
S
D
V
I
NEI
Q
GLH
S
AG
Q
G
TE
RY
--
R
LTHTR
VRD
F
H
TD
EGD
EQP
V
G
LG
Q
L
I
PRI
V
S
--
GA
D
D
LS
A
MV
TLPL
C
RI
LN
K
N
A
T
G
A
L
V
L
D
N
T
FIP
TI
Q
A
VR
VS
GL
L
GAF
S
G
EVQ
GL
L
AT
RA
A
DLA
G
--
RI
G
S
PEQ
SG
--
IADVAEFMMLQ
M
LNR
H
Q
MQ
FTH
RS
Q
LHT
LHPE
AF
Y
Q
DL
V
G
LLGELMTF
T
E
G
-
N
RLPC
T
V
E
-------
P
Y
N
H
R
DL
TA
TF
T
R
T
V
I
PE
L
R
RAL
N
TVL
V
PRA
Q
NL
P
L
FFSE
G
T
-
W
---
I
A
T
I
S
D
PT
LLQ
S
C
K
L
VLAV
R
A
R
-
MP
Y
DQ
V
Q
R
QFIQQSK
V
A
ATD
KI
RS
V
VSVQ
V
PGI
P
L
HT
L
T
A
APRQLP
W
H
E
G
YV
YFEL
E
K
GTP
AW
QD
V
IK
AG
AL
ALH
I
SG
T
FPDLN
L
QLWAIRG
fig|656379.3.peg.816
Escherichia coli FVEC1302
MAT
MK
NKV
I
W
Q
EG
L
F
AL
PQHFQQQQR
H
CE
YL
LNR
R
LD
A
LGDFF
WGF
T
E
LSI
N
T
ELL
AQ
GKIMID
R
A
A
G
CM
PDGTVFS
I
P
DQ
D
L
LP
E
P
-
FQ
P
GT
L
S
S
KE
S
HN
IYLALPV
I
S
D
V
I
NEI
Q
GLH
S
AG
Q
G
TE
RY
--
R
LTHTR
VRD
F
H
TD
EGD
EQP
V
G
LG
Q
L
I
PRI
V
S
--
GA
D
D
LS
A
MV
TLPL
C
RI
LN
K
N
A
T
G
A
L
V
L
D
N
T
FIP
TI
Q
A
VR
VS
GL
L
GAF
S
G
EVQ
GL
L
AT
RA
A
DLA
G
--
RI
G
S
PEQ
SG
--
IADVAEFMMLQ
M
LNR
H
Q
MQ
FTH
RS
Q
LHT
LHPE
AF
Y
Q
DL
V
G
LLGELMTF
T
E
G
-
N
RLPC
T
V
E
-------
P
Y
N
H
R
DL
TA
TF
T
R
T
V
I
PE
L
R
RAL
N
TVL
V
PRA
Q
NL
P
L
FFSE
G
T
-
W
---
I
A
T
I
S
D
PT
LLQ
S
C
K
L
VLAV
R
A
R
-
MP
Y
DQ
V
Q
R
QFIQQSK
V
A
ATD
KI
RS
V
VSVQ
V
PGI
P
L
HT
L
T
A
APRQLP
W
H
E
G
YV
YFEL
E
K
GTP
AW
QD
V
IK
AG
AL
ALH
I
SG
T
FPDLN
L
QLWAIRG
fig|656380.3.peg.719
Escherichia coli FVEC1412
MAT
MK
NKV
I
W
Q
EG
L
F
AL
PQHFQQQQR
H
CE
YL
LNR
R
LD
A
LGDFF
WGF
T
E
LSI
N
T
ELL
AQ
GKIMID
R
A
A
G
CM
PDGTVFS
I
P
DQ
D
L
LP
E
P
-
FQ
P
GT
L
S
S
KE
S
HN
IYLALPV
I
S
D
V
I
NEI
Q
GLH
S
AG
Q
G
TE
RY
--
R
LTHTR
VRD
F
H
TD
EGD
EQP
V
G
LG
Q
L
I
PRI
V
S
--
GA
D
D
LS
A
MV
TLPL
C
RI
LN
K
N
A
T
G
A
L
V
L
D
N
T
FIP
TI
Q
A
VR
VS
GL
L
GAF
S
G
EVQ
GL
L
AT
RA
A
DLA
G
--
RI
G
S
PEQ
SG
--
IADVAEFMMLQ
M
LNR
H
Q
MQ
FTH
RS
Q
LHT
LHPE
AF
Y
Q
DL
V
G
LLGELMTF
T
E
G
-
N
RLPC
T
V
E
-------
P
Y
N
H
R
DL
TA
TF
T
R
T
V
I
PE
L
R
RAL
N
TVL
V
PRA
Q
NL
P
L
FFSE
G
T
-
W
---
I
A
T
I
S
D
PT
LLQ
S
C
K
L
VLAV
R
A
R
-
MP
Y
DQ
V
Q
R
QFIQQSK
V
A
ATD
KI
RS
V
VSVQ
V
PGI
P
L
HT
L
T
A
APRQLP
W
H
E
G
YV
YFEL
E
K
GTP
AW
QD
V
IK
AG
AL
ALH
I
SG
T
FPDLN
L
QLWAIRG
fig|749549.3.peg.3845
Escherichia coli MS 198-1
MAT
MK
NKV
I
W
Q
EG
L
F
AL
PQHFQQQQR
H
CE
YL
LNR
R
LD
A
LGDFF
WGF
T
E
LSI
N
T
ELL
AQ
GKIMID
R
A
A
G
CM
PDGTVFS
I
P
DQ
D
L
LP
E
P
-
FQ
P
GT
L
S
S
KE
S
HN
IYLALPV
I
S
D
V
I
NEI
Q
GLH
S
AG
Q
G
TE
RY
--
R
LTHTR
VRD
F
H
TD
EGD
EQP
V
G
LG
Q
L
I
PRI
V
S
--
GA
D
D
LS
A
MV
TLPL
C
RI
LN
K
N
A
T
G
A
L
V
L
D
N
T
FIP
TI
Q
A
VR
VS
GL
L
GAF
S
G
EVQ
GL
L
AT
RA
A
DLA
G
--
RI
G
S
PEQ
SG
--
IADVAEFMMLQ
M
LNR
H
Q
MQ
FTH
RS
Q
LHT
LHPE
AF
Y
Q
DL
V
G
LLGELMTF
T
E
G
-
N
RLPC
T
V
E
-------
P
Y
N
H
R
DL
TA
TF
T
R
T
V
I
PE
L
R
RAL
N
TVL
V
PRA
Q
NL
P
L
FFSE
G
T
-
W
---
I
A
T
I
S
D
PT
LLQ
S
C
K
L
VLAV
R
A
R
-
MP
Y
DQ
V
Q
R
QFIQQSK
V
A
ATD
KI
RS
V
VSVQ
V
PGI
P
L
HT
L
T
A
APRQLP
W
H
E
G
YV
YFEL
E
K
GTP
AW
QD
V
IK
AG
AL
ALH
I
SG
T
FPDLN
L
QLWAIRG
fig|656437.3.peg.290
Escherichia coli TA143
MAT
MK
NKV
I
W
Q
EG
L
F
AL
PQHFQQQQR
H
CE
YL
LNR
R
LD
A
LGDFF
WGF
T
E
LSI
N
T
ELL
AQ
GKIMID
R
A
A
G
CM
PDGTVFS
I
P
DQ
D
L
LP
E
P
-
FQ
P
GT
L
S
S
KE
S
HN
IYLALPV
I
S
D
V
I
NEI
Q
GLH
S
AG
Q
G
TE
RY
--
R
LTHTR
VRD
F
H
TD
EGD
EQP
V
G
LG
Q
L
I
PRI
V
S
--
GA
D
D
LS
A
MV
TLPL
C
RI
LN
K
N
A
T
G
A
L
V
L
D
N
T
FIP
TI
Q
A
VR
VS
GL
L
GAF
S
G
EVQ
GL
L
AT
RA
A
DLA
G
--
RI
G
S
PEQ
SG
--
IADVAEFMMLQ
M
LNR
H
Q
MQ
FTH
RS
Q
LHT
LHPE
AF
Y
Q
DL
V
G
LLGELMTF
T
E
G
-
N
RLPC
T
V
E
-------
P
Y
N
H
R
DL
TA
TF
T
R
T
V
I
PE
L
R
RAL
N
TVL
V
PRA
Q
NL
P
L
FFSE
G
T
-
W
---
I
A
T
I
S
D
PT
LLQ
S
C
K
L
VLAV
R
A
R
-
MP
Y
DQ
V
Q
R
QFIQQSK
V
A
ATD
KI
RS
V
VSVQ
V
PGI
P
L
HT
L
T
A
APRQLP
W
H
E
G
YV
YFEL
E
K
GTP
AW
QD
V
IK
AG
AL
ALH
I
SG
T
FPDLN
L
QLWAIRG
fig|585056.7.peg.410
Escherichia coli UMN026
MAT
MK
NKV
I
W
Q
EG
L
F
AL
PQHFQQQQR
H
CE
YL
LNR
R
LD
A
LGDFF
WGF
T
E
LSI
N
T
ELL
AQ
GKIMID
R
A
A
G
CM
PDGTVFS
I
P
DQ
D
L
LP
E
P
-
FQ
P
GT
L
S
S
KE
S
HN
IYLALPV
I
S
D
V
I
NEI
Q
GLH
S
AG
Q
G
TE
RY
--
R
LTHTR
VRD
F
H
TD
EGD
EQP
V
G
LG
Q
L
I
PRI
V
S
--
GA
D
D
LS
A
MV
TLPL
C
RI
LN
K
N
A
T
G
A
L
V
L
D
N
T
FIP
TI
Q
A
VR
VS
GL
L
GAF
S
G
EVQ
GL
L
AT
RA
A
DLA
G
--
RI
G
S
PEQ
SG
--
IADVAEFMMLQ
M
LNR
H
Q
MQ
FTH
RS
Q
LHT
LHPE
AF
Y
Q
DL
V
G
LLGELMTF
T
E
G
-
N
RLPC
T
V
E
-------
P
Y
N
H
R
DL
TA
TF
T
R
T
V
I
PE
L
R
RAL
N
TVL
V
PRA
Q
NL
P
L
FFSE
G
T
-
W
---
I
A
T
I
S
D
PT
LLQ
S
C
K
L
VLAV
R
A
R
-
MP
Y
DQ
V
Q
R
QFIQQSK
V
A
ATD
KI
RS
V
VSVQ
V
PGI
P
L
HT
L
T
A
APRQLP
W
H
E
G
YV
YFEL
E
K
GTP
AW
QD
V
IK
AG
AL
ALH
I
SG
T
FPDLN
L
QLWAIRG
fig|753642.3.peg.1480
Escherichia coli NC101
MAT
MK
NKV
I
W
Q
EG
L
F
AL
PQHFQQQQR
H
CE
YL
LTR
R
LD
A
LGDFF
WGF
T
E
LSI
N
T
ELL
AQ
GKIMID
R
A
A
G
CM
PDGTVFS
I
P
DQ
D
L
LP
E
P
-
FQ
P
GT
L
S
S
KE
S
HN
IYLALPV
I
S
D
V
I
NEI
Q
GLH
S
AG
Q
G
TE
RY
--
R
LTHTR
VRD
F
H
TD
EGD
EQP
V
G
LG
Q
L
I
PRI
V
S
--
GA
D
D
LS
A
MV
TLPL
C
RI
LN
K
N
A
T
G
A
L
V
L
D
N
T
FIP
TI
Q
A
VR
VS
GL
L
GAF
S
G
EVQ
GL
L
AT
RA
A
DLA
G
--
RI
G
S
PEQ
SG
--
IADVAEFMMLQ
M
LNR
Y
Q
MQ
FTH
RS
Q
LHT
LHPE
AF
Y
R
DL
V
G
LLGELMTF
T
E
G
-
N
RLPC
T
V
E
-------
P
Y
N
H
R
DL
TA
TF
T
R
T
V
I
PE
L
R
RAL
N
TVL
V
PRA
Q
NL
P
L
FFSE
G
T
-
W
---
I
A
T
I
N
D
PT
LLQ
S
C
K
M
VLAV
R
A
R
-
MP
Y
DQ
V
Q
R
QFIQQSK
V
A
ATD
KI
RS
V
VSVQ
V
PGI
P
L
HT
L
T
A
APRQLP
Y
H
E
G
YV
YFEL
E
K
GTP
AW
QD
V
IK
AG
AL
ALH
I
SGSFPDLN
L
QLWAIRG
fig|685038.3.peg.224
Escherichia coli O83:H1 str. NRG 857C
MAT
MK
NKV
I
W
Q
EG
L
F
AL
PQHFQQQQR
H
CE
YL
LTR
R
LD
A
LGDFF
WGF
T
E
LSI
N
T
ELL
AQ
GKIMID
R
A
A
G
CM
PDGTVFS
I
P
DQ
D
L
LP
E
P
-
FQ
P
GT
L
S
S
KE
S
HN
IYLALPV
I
S
D
V
I
NEI
Q
GLH
S
AG
Q
G
TE
RY
--
R
LTHTR
VRD
F
H
TD
EGD
EQP
V
G
LG
Q
L
I
PRI
V
S
--
GA
D
D
LS
A
MV
TLPL
C
RI
LN
K
N
A
T
G
A
L
V
L
D
N
T
FIP
TI
Q
A
VR
VS
GL
L
GAF
S
G
EVQ
GL
L
AT
RA
A
DLA
G
--
RI
G
S
PEQ
SG
--
IADVAEFMMLQ
M
LNR
Y
Q
MQ
FTH
RS
Q
LHT
LHPE
AF
Y
R
DL
V
G
LLGELMTF
T
E
G
-
N
RLPC
T
V
E
-------
P
Y
N
H
R
DL
TA
TF
T
R
T
V
I
PE
L
R
RAL
N
TVL
V
PRA
Q
NL
P
L
FFSE
G
T
-
W
---
I
A
T
I
N
D
PT
LLQ
S
C
K
M
VLAV
R
A
R
-
MP
Y
DQ
V
Q
R
QFIQQSK
V
A
ATD
KI
RS
V
VSVQ
V
PGI
P
L
HT
L
T
A
APRQLP
Y
H
E
G
YV
YFEL
E
K
GTP
AW
QD
V
IK
AG
AL
ALH
I
SGSFPDLN
L
QLWAIRG
fig|362663.8.peg.233
Escherichia coli 536
MAT
MK
NKV
I
W
Q
EG
L
F
AL
PQHFQQQQR
H
CE
YL
LTR
R
LD
A
QGDFF
WGF
T
E
LSI
N
T
ELL
AQ
GKIMID
R
A
A
G
CM
PDGTVFS
I
P
DQ
D
L
LP
E
P
-
FQ
P
GT
L
S
S
KE
S
HN
IYLALPV
I
S
D
V
I
NEI
Q
GLH
S
AG
Q
G
TE
RY
--
R
LTHTR
VRD
F
H
TD
EGD
EQP
V
G
LG
Q
L
I
PRI
V
S
--
GA
D
D
LS
A
MV
TLPL
C
RI
LN
K
N
A
T
G
A
L
V
L
D
N
T
FIP
TI
Q
A
VR
VS
GL
L
GAF
S
G
EVQ
GL
L
AT
RA
A
DLA
G
--
RI
G
S
PEQ
SG
--
IADVAEFMMLQ
M
LNR
Y
Q
MQ
FTH
RS
Q
LHT
LHPE
AF
Y
R
DL
V
G
LLGELMTF
I
E
G
-
N
RLPC
T
V
E
-------
P
Y
N
H
R
DL
TA
TF
T
R
T
V
I
PE
L
R
RAL
N
TVL
V
PRA
Q
NL
P
L
FFSE
G
T
-
W
---
I
A
T
I
N
D
PT
LLQ
S
C
K
L
VLAV
R
A
R
-
MP
Y
DQ
V
Q
R
QFIQQSK
V
A
ATD
KI
RS
V
VSVQ
V
PGI
P
L
HT
L
T
A
APRQLP
Y
H
E
G
YV
YFEL
E
K
GTP
AW
QD
V
IK
AG
AL
ALH
I
SGSFPDLN
L
QLWAIRG
fig|362663.9.peg.233
Escherichia coli 536
MAT
MK
NKV
I
W
Q
EG
L
F
AL
PQHFQQQQR
H
CE
YL
LTR
R
LD
A
QGDFF
WGF
T
E
LSI
N
T
ELL
AQ
GKIMID
R
A
A
G
CM
PDGTVFS
I
P
DQ
D
L
LP
E
P
-
FQ
P
GT
L
S
S
KE
S
HN
IYLALPV
I
S
D
V
I
NEI
Q
GLH
S
AG
Q
G
TE
RY
--
R
LTHTR
VRD
F
H
TD
EGD
EQP
V
G
LG
Q
L
I
PRI
V
S
--
GA
D
D
LS
A
MV
TLPL
C
RI
LN
K
N
A
T
G
A
L
V
L
D
N
T
FIP
TI
Q
A
VR
VS
GL
L
GAF
S
G
EVQ
GL
L
AT
RA
A
DLA
G
--
RI
G
S
PEQ
SG
--
IADVAEFMMLQ
M
LNR
Y
Q
MQ
FTH
RS
Q
LHT
LHPE
AF
Y
R
DL
V
G
LLGELMTF
I
E
G
-
N
RLPC
T
V
E
-------
P
Y
N
H
R
DL
TA
TF
T
R
T
V
I
PE
L
R
RAL
N
TVL
V
PRA
Q
NL
P
L
FFSE
G
T
-
W
---
I
A
T
I
N
D
PT
LLQ
S
C
K
L
VLAV
R
A
R
-
MP
Y
DQ
V
Q
R
QFIQQSK
V
A
ATD
KI
RS
V
VSVQ
V
PGI
P
L
HT
L
T
A
APRQLP
Y
H
E
G
YV
YFEL
E
K
GTP
AW
QD
V
IK
AG
AL
ALH
I
SGSFPDLN
L
QLWAIRG
fig|340197.3.peg.1536
Escherichia coli F11
MAT
MK
NKV
I
W
Q
EG
L
F
AL
PQHFQQQQR
H
CE
YL
LTR
R
LD
A
QGDFF
WGF
T
E
LSI
N
T
ELL
AQ
GKIMID
R
A
A
G
CM
PDGTVFS
I
P
DQ
D
L
LP
E
P
-
FQ
P
GT
L
S
S
KE
S
HN
IYLALPV
I
S
D
V
I
NEI
Q
GLH
S
AG
Q
G
TE
RY
--
R
LTHTR
VRD
F
H
TD
EGD
EQP
V
G
LG
Q
L
I
PRI
V
S
--
GA
D
D
LS
A
MV
TLPL
C
RI
LN
K
N
A
T
G
A
L
V
L
D
N
T
FIP
TI
Q
A
VR
VS
GL
L
GAF
S
G
EVQ
GL
L
AT
RA
A
DLA
G
--
RI
G
S
PEQ
SG
--
IADVAEFMMLQ
M
LNR
Y
Q
MQ
FTH
RS
Q
LHT
LHPE
AF
Y
R
DL
V
G
LLGELMTF
I
E
G
-
N
RLPC
T
V
E
-------
P
Y
N
H
R
DL
TA
TF
T
R
T
V
I
PE
L
R
RAL
N
TVL
V
PRA
Q
NL
P
L
FFSE
G
T
-
W
---
I
A
T
I
N
D
PT
LLQ
S
C
K
L
VLAV
R
A
R
-
MP
Y
DQ
V
Q
R
QFIQQSK
V
A
ATD
KI
RS
V
VSVQ
V
PGI
P
L
HT
L
T
A
APRQLP
Y
H
E
G
YV
YFEL
E
K
GTP
AW
QD
V
IK
AG
AL
ALH
I
SGSFPDLN
L
QLWAIRG
fig|340197.5.peg.1628
Escherichia coli F11
MAT
MK
NKV
I
W
Q
EG
L
F
AL
PQHFQQQQR
H
CE
YL
LTR
R
LD
A
QGDFF
WGF
T
E
LSI
N
T
ELL
AQ
GKIMID
R
A
A
G
CM
PDGTVFS
I
P
DQ
D
L
LP
E
P
-
FQ
P
GT
L
S
S
KE
S
HN
IYLALPV
I
S
D
V
I
NEI
Q
GLH
S
AG
Q
G
TE
RY
--
R
LTHTR
VRD
F
H
TD
EGD
EQP
V
G
LG
Q
L
I
PRI
V
S
--
GA
D
D
LS
A
MV
TLPL
C
RI
LN
K
N
A
T
G
A
L
V
L
D
N
T
FIP
TI
Q
A
VR
VS
GL
L
GAF
S
G
EVQ
GL
L
AT
RA
A
DLA
G
--
RI
G
S
PEQ
SG
--
IADVAEFMMLQ
M
LNR
Y
Q
MQ
FTH
RS
Q
LHT
LHPE
AF
Y
R
DL
V
G
LLGELMTF
I
E
G
-
N
RLPC
T
V
E
-------
P
Y
N
H
R
DL
TA
TF
T
R
T
V
I
PE
L
R
RAL
N
TVL
V
PRA
Q
NL
P
L
FFSE
G
T
-
W
---
I
A
T
I
N
D
PT
LLQ
S
C
K
L
VLAV
R
A
R
-
MP
Y
DQ
V
Q
R
QFIQQSK
V
A
ATD
KI
RS
V
VSVQ
V
PGI
P
L
HT
L
T
A
APRQLP
Y
H
E
G
YV
YFEL
E
K
GTP
AW
QD
V
IK
AG
AL
ALH
I
SGSFPDLN
L
QLWAIRG
fig|749550.3.peg.3580
Escherichia coli MS 200-1
MAT
MK
NKV
I
W
Q
EG
L
F
AL
PQHFQQQQR
H
CE
YL
LTR
R
LD
A
QGDFF
WGF
T
E
LSI
N
T
ELL
AQ
GKIMID
R
A
A
G
CM
PDGTVFS
I
P
DQ
D
L
LP
E
P
-
FQ
P
GT
L
S
S
KE
S
HN
IYLALPV
I
S
D
V
I
NEI
Q
GLH
S
AG
Q
G
TE
RY
--
R
LTHTR
VRD
F
H
TD
EGD
EQP
V
G
LG
Q
L
I
PRI
V
S
--
GA
D
D
LS
A
MV
TLPL
C
RI
LN
K
N
A
T
G
A
L
V
L
D
N
T
FIP
TI
Q
A
VR
VS
GL
L
GAF
S
G
EVQ
GL
L
AT
RA
A
DLA
G
--
RI
G
S
PEQ
SG
--
IADVAEFMMLQ
M
LNR
Y
Q
MQ
FTH
RS
Q
LHT
LHPE
AF
Y
R
DL
V
G
LLGELMTF
I
E
G
-
N
RLPC
T
V
E
-------
P
Y
N
H
R
DL
TA
TF
T
R
T
V
I
PE
L
R
RAL
N
TVL
V
PRA
Q
NL
P
L
FFSE
G
T
-
W
---
I
A
T
I
N
D
PT
LLQ
S
C
K
L
VLAV
R
A
R
-
MP
Y
DQ
V
Q
R
QFIQQSK
V
A
ATD
KI
RS
V
VSVQ
V
PGI
P
L
HT
L
T
A
APRQLP
Y
H
E
G
YV
YFEL
E
K
GTP
AW
QD
V
IK
AG
AL
ALH
I
SGSFPDLN
L
QLWAIRG
fig|550677.3.peg.614
Escherichia coli B354 (5-445/447)
N
R
V
V
W
S
EG
Q
F
LL
PQ
M
FQQQ
E
RY
LE
HV
IHY
R
SL
P
LSPFY
WGF
N
E
YGI
G
S
E
A
L
NI
GK
L
VL
T
K
A
S
G
VF
A
DGT
P
F
N
A
P
GH
T
P
LP
P
P
-
L-
-
TI
L
P
E
HL
N
QL
IYLA
V
P
I
R
T
P
N
S
E
E
T
-
SFD
N
NP
ES
LA
R
F
--
S
VHESE
I
RD
A
N
SL
GRG
AQL
L
Q
L
S
H
L
R
L
R
L
L
P
--
EKAV
TD
A
W
I
G
LPL
T
RI
TA
L
H
P
D
G
R
V
D
I
D
K
E
L
IP
PV
A
N
YQ
A
S
TL
I
CTW
L
S
W
I
N
DL
I
KM
RA
D
S
LA
E
--
R
L
T
G
SDK
H
G
HEA
A
E
V
S
DYL
L
LQ
V
LNR
F
G
PL
L
I
H
MS
K
-TP
L
S
PE
VL
Y
R
N
L
C
A
L
A
GEL
S
T
Y
V
R
P
Q
T
R
R
P
E
E
Y
K
-------
E
Y
K
H
L
T
P
YA
GL
-
K
S
V
V
D
EV
Q
Y
L
L
N
A
VL
I
RG
A
Q
R
I
P
L
--EE
G
T
-
Y
GIL
N
A
V
V
EP
TE
L
SD
F
S
S
L
VLAV
K
A
Q
-
M
S
A
D
T
L
L
Q
H
F
SA
Q
T
KI
G
PS
E
RL
PE
L
I
RSH
L
PG
L
V
L
QV
L
P
V
P
PRQ
I
P
F
Q
S
G
YI
Y
YDI
R
R
DGV
L
W
EH
I
AR
Y
G
GM
A
M
H
T
A
G
E
FP
G
L
E
L
E
LW
G
V
R
fig|656444.3.peg.629
Escherichia coli TA280 (5-445/447)
N
R
V
V
W
S
EG
Q
F
LL
PQ
M
FQQQ
E
RY
LE
HV
IHY
R
SL
P
LSPFY
WGF
N
E
YGI
G
S
E
A
L
NI
GK
L
VL
T
K
A
S
G
VF
A
DGT
P
F
N
A
P
GH
T
P
LP
P
P
-
L-
-
TI
L
P
E
HL
N
QL
IYLA
V
P
I
R
T
P
N
S
E
E
T
-
SFD
N
NP
ES
LA
R
F
--
S
VHESE
I
RD
A
N
SL
GRG
AQL
L
Q
L
S
H
L
R
L
R
L
L
P
--
EKAV
TD
A
W
I
G
LPL
T
RI
TA
L
H
P
D
G
R
V
D
I
D
K
E
L
IP
PV
A
N
YQ
A
S
TL
I
CTW
L
S
W
I
N
DL
I
KM
RA
D
S
LA
E
--
R
L
T
G
SDK
H
G
HEA
A
E
V
S
DYL
L
LQ
V
LNR
F
G
PL
L
I
H
MS
K
-TP
L
S
PE
VL
Y
R
N
L
C
A
L
A
GEL
S
T
Y
V
R
P
Q
T
R
R
P
E
E
Y
K
-------
E
Y
K
H
L
T
P
YA
GL
-
K
S
V
V
D
EV
Q
Y
L
L
N
A
VL
I
RG
A
Q
R
I
P
L
--EE
G
T
-
Y
GIL
N
A
V
V
EP
TE
L
SD
F
S
S
L
VLAV
K
A
Q
-
M
S
A
D
T
L
L
Q
H
F
SA
Q
T
KI
G
PS
E
RL
PE
L
I
RSH
L
PG
L
V
L
QV
L
P
V
P
PRQ
I
P
F
Q
S
G
YI
Y
YDI
R
R
DGV
L
W
EH
I
AR
Y
G
GM
A
M
H
T
A
G
E
FP
G
L
E
L
E
LW
G
V
R
fig|216592.1.peg.2477
Escherichia coli 042 (7-442/445)
L
W
E
D
G
A
F
LM
PQ
Q
FQQQ
A
A
W
DV
H
L
ADS
V
AR
M
GLAHP
WG
V
V
A
AEF
D
D
S
LL
PL
S
R
L
NAT
R
L
I
V
RF
PDGT
LID
T
E
RA
D
N
LP
P
V
-
CD
L
ST
V
S
D
RS
L
VD
I
V
LALP
L
L
N
A
N
G
GNL
-
DNG
S
ES
E
R
PR
R
W
--
K
SERVN
V
Q
E
L
A
GH
E
QS
EVA
V
L
RH
N
L
T
L
R
M
-
-
--
AH
QE
NA
A
WL
T
C
P
V
T
R
L
V-
R
D
A
Q
G
Q
W
C
R
D
P
R
FIP
PL
L
T
LS
A
S
PS
L
MTE
L
A
E
LL
HH
L
QA
R
R
Q
R
L
M
S
MR
R
E
N
N
ARL
ADFAV
ADV
SL
F
WL
L
N
A
LN
S
A
E
PV
L
KE
LL
D
MPY
R
HPE
LL
Y
R
E
LA
R
L
A
G
S
L
L
TF
S
L
-
-
E
HNV
D
A
V
P
-------
A
Y
H
H
E
T
P
EN
V
F
-
P
P
L
L
SLL
N
R
L
L
E
AS
L
P
S
R
V
V
F
I
E
L
KQ-K
G
V
M
W
---
E
G
A
L
HD
AR
L
RE
G
A
D
F
W
L
S
V
RS
S
-
MP
G
H
EL
Q
T
K
F
P
Q
L
C
K
A
G
SP
DDV
SE
V
V
N
V
A
L
S
G
V
I
I
RP
V
T
H
V
P
AA
I
P
L
R
L
E
NQ
YF
A
LD
L
STD
A
A
RA
M
LD
AG
RC
TF
Y
T
P
A
S
L
G
D
V
K
L
E
L
F
A
V
fig|585055.6.peg.3372
Escherichia coli 55989 (7-442/445)
L
W
E
D
G
A
F
LM
PQ
Q
FQQQ
A
A
W
DV
H
L
ADS
V
AR
M
GLAHP
WG
V
V
A
AEF
D
D
S
LL
PL
S
R
L
NAT
R
L
I
V
RF
PDGT
LID
T
E
RA
D
N
LP
P
V
-
CD
L
ST
V
S
D
RS
L
VD
I
V
LALP
L
L
N
A
N
G
GNL
-
DNG
S
ES
E
R
PR
R
W
--
K
SERVN
V
Q
E
L
A
GH
E
QS
EVA
V
L
RH
N
L
T
L
R
M
-
-
--
AH
QE
NA
A
WL
T
C
P
V
T
R
L
V-
R
D
A
Q
G
Q
W
C
R
D
P
R
FIP
PL
L
T
LS
A
G
PS
L
MTE
L
A
E
LL
HH
L
QA
R
R
Q
R
L
M
S
MR
R
E
N
N
ARL
ADFAV
ADV
SL
F
WL
L
N
A
LN
S
A
E
PV
L
KE
LL
D
MPY
R
HPE
LL
Y
R
E
LA
R
L
A
G
S
L
L
TF
S
L
-
-
E
HNV
D
A
V
P
-------
A
Y
H
H
E
T
P
EN
V
F
-
P
P
L
L
SLL
N
R
L
L
E
AS
L
P
S
R
V
V
F
I
E
L
KQ-K
G
V
M
W
---
E
G
A
L
HD
AR
L
RE
G
A
D
F
W
L
S
V
RS
S
-
MP
G
H
EL
Q
T
K
F
P
Q
L
C
K
A
G
SP
DDV
SE
V
V
N
V
A
L
S
G
V
I
I
RP
V
T
H
V
P
AA
I
P
L
R
L
E
NQ
YF
A
LD
L
STD
A
A
RA
M
LD
AG
RC
TF
Y
T
P
A
S
L
G
D
V
K
L
E
L
F
A
V
fig|585055.8.peg.3377
Escherichia coli 55989 (7-442/445)
L
W
E
D
G
A
F
LM
PQ
Q
FQQQ
A
A
W
DV
H
L
ADS
V
AR
M
GLAHP
WG
V
V
A
AEF
D
D
S
LL
PL
S
R
L
NAT
R
L
I
V
RF
PDGT
LID
T
E
RA
D
N
LP
P
V
-
CD
L
ST
V
S
D
RS
L
VD
I
V
LALP
L
L
N
A
N
G
GNL
-
DNG
S
ES
E
R
PR
R
W
--
K
SERVN
V
Q
E
L
A
GH
E
QS
EVA
V
L
RH
N
L
T
L
R
M
-
-
--
AH
QE
NA
A
WL
T
C
P
V
T
R
L
V-
R
D
A
Q
G
Q
W
C
R
D
P
R
FIP
PL
L
T
LS
A
G
PS
L
MTE
L
A
E
LL
HH
L
QA
R
R
Q
R
L
M
S
MR
R
E
N
N
ARL
ADFAV
ADV
SL
F
WL
L
N
A
LN
S
A
E
PV
L
KE
LL
D
MPY
R
HPE
LL
Y
R
E
LA
R
L
A
G
S
L
L
TF
S
L
-
-
E
HNV
D
A
V
P
-------
A
Y
H
H
E
T
P
EN
V
F
-
P
P
L
L
SLL
N
R
L
L
E
AS
L
P
S
R
V
V
F
I
E
L
KQ-K
G
V
M
W
---
E
G
A
L
HD
AR
L
RE
G
A
D
F
W
L
S
V
RS
S
-
MP
G
H
EL
Q
T
K
F
P
Q
L
C
K
A
G
SP
DDV
SE
V
V
N
V
A
L
S
G
V
I
I
RP
V
T
H
V
P
AA
I
P
L
R
L
E
NQ
YF
A
LD
L
STD
A
A
RA
M
LD
AG
RC
TF
Y
T
P
A
S
L
G
D
V
K
L
E
L
F
A
V
fig|216592.3.peg.4703
Escherichia coli 042 (2-428/431)
PQ
Q
FQQQ
A
A
W
DV
H
L
ADS
V
AR
M
GLAHP
WG
V
V
A
AEF
D
D
S
LL
PL
S
R
L
NAT
R
L
I
V
RF
PDGT
LID
T
E
RA
D
N
LP
P
V
-
CD
L
ST
V
S
D
RS
L
VD
I
V
LALP
L
L
N
A
N
G
GNL
-
DNG
S
ES
E
R
PR
R
W
--
K
SERVN
V
Q
E
L
A
GH
E
QS
EVA
V
L
RH
N
L
T
L
R
M
-
-
--
AH
QE
NA
A
WL
T
C
P
V
T
R
L
V-
R
D
A
Q
G
Q
W
C
R
D
P
R
FIP
PL
L
T
LS
A
S
PS
L
MTE
L
A
E
LL
HH
L
QA
R
R
Q
R
L
M
S
MR
R
E
N
N
ARL
ADFAV
ADV
SL
F
WL
L
N
A
LN
S
A
E
PV
L
KE
LL
D
MPY
R
HPE
LL
Y
R
E
LA
R
L
A
G
S
L
L
TF
S
L
-
-
E
HNV
D
A
V
P
-------
A
Y
H
H
E
T
P
EN
V
F
-
P
P
L
L
SLL
N
R
L
L
E
AS
L
P
S
R
V
V
F
I
E
L
KQ-K
G
V
M
W
---
E
G
A
L
HD
AR
L
RE
G
A
D
F
W
L
S
V
RS
S
-
MP
G
H
EL
Q
T
K
F
P
Q
L
C
K
A
G
SP
DDV
SE
V
V
N
V
A
L
S
G
V
I
I
RP
V
T
H
V
P
AA
I
P
L
R
L
E
NQ
YF
A
LD
L
STD
A
A
RA
M
LD
AG
RC
TF
Y
T
P
A
S
L
G
D
V
K
L
E
L
F
A
V
fig|331111.3.peg.838
Escherichia coli E24377A (4-442/445)
HRP
L
W
A
EG
T
F
LS
S
Q
Q
FQQQ
A
R
W
EA
FS
NDS
I
AQ
L
CIRHP
WG
I
A
N
VLF
D
R
DA
L
MS
GK
LKT
Q
A
V
R
L
RF
A
DGT
LID
S
D
VS
D
V
LP
L
A
-
CD
L
HA
L
T
N
DS
A
V-
VL
LALP
L
A
H
G
N
G
GNL
-
GQG
E
QT
E
R
PL
RY
--
R
QEWQK
V
Q
D
I
Y
GS
DS
E
DMA
V
E
RH
A
L
S
L
R
F
-
-
--
AHDN
NQ
G
YIT
C
PL
A
R
L
V-
R
D
V
Q
G
N
W
T
Q
D
E
G
Y
IP
PL
LA
FN
AH
DG
L
VQR
L
D
TLL
LQ
L
RA
KC
Q
R
L
M
A
MR
R
E
S
N
QRM
ADFAV
ADV
SL
F
WL
L
N
A
LN
S
A
E
PV
LSD
FL
R
YPA
V
HPE
LV
W
R
E
LA
R
L
A
G
A
L
L
TF
S
L
-
-
E
HNVS
A
V
P
-------
P
Y
V
H
E
S
P
ST
V
F
-
P
P
L
F
SLL
S
EL
L
E
AS
L
P
S
R
V
I
A
L
D
L
ESLP
G
N
R
W
---
K
A
D
L
HD
PR
L
RE
E
A
D
F
Y
L
S
V
RS
S
-
L
P
A
H
Q
V
L
H
Q
LPLVC
KI
G
A
P
DDV
TL
L
IN
V
A
L
N
G
V
P
L
VP
L
T
S
V
P
AA
LP
L
R
L
E
NQ
YF
A
LD
M
HSD
A
A
KS
M
LE
S
G
CC
MIY
A
P
G
TMG
DL
K
P
E
L
F
A
V
fig|753642.3.peg.331
Escherichia coli NC101 (7-442/445)
L
W
A
EG
T
F
LS
S
Q
Q
FQQQ
A
R
W
EA
FS
NDS
I
AQ
L
CIRHP
WG
I
A
N
VLF
D
R
DA
L
AL
GK
LKT
Q
A
V
R
L
RF
A
DGT
LID
S
D
VS
D
I
LP
P
A
-
CD
L
RT
L
E
G
DS
A
I-
VL
LALP
L
A
H
G
N
G
GNL
-
GQG
E
QA
E
R
PL
RY
--
R
QEWQK
V
Q
D
I
Y
GS
DS
E
DMA
V
E
RH
A
L
S
L
R
F
-
-
--
AHDN
NQ
D
YIT
C
PL
A
R
L
V-
R
D
V
Q
G
N
W
T
Q
D
E
S
Y
IP
PL
LA
FN
AH
DG
L
VQR
L
D
TLL
LQ
L
RA
KC
Q
R
L
M
A
MR
R
E
S
N
QRM
ADFAV
ADV
SL
F
WL
L
N
A
LN
S
A
E
PV
LSD
FL
R
YPA
V
HPE
LV
W
R
E
LA
R
L
A
G
A
L
L
TF
S
L
-
-
E
HNVS
A
V
P
-------
P
Y
V
H
E
S
P
ST
V
F
-
P
P
L
F
SLL
S
EL
L
E
AS
L
P
S
R
V
I
A
L
D
L
ASLP
G
N
R
W
---
K
A
D
L
HD
PR
L
RE
E
A
D
F
Y
L
S
V
RS
S
-
L
P
A
H
Q
V
L
H
Q
LPLVC
KI
G
A
P
DDV
TL
L
IN
V
A
L
N
G
V
P
L
VP
L
T
S
V
P
AA
LP
L
R
L
E
NQ
YF
A
LD
M
HSD
A
A
KS
M
LE
S
G
CC
MIY
A
P
G
TMG
DL
K
P
E
L
F
A
V
fig|344601.3.peg.724
Escherichia coli B171 (4-442/445)
HRP
L
W
A
EG
T
F
LS
S
Q
Q
FQQQ
A
R
W
EA
FS
NDS
I
AQ
L
CIRHP
WG
I
A
N
VLF
D
R
DA
L
MS
GK
LKT
Q
A
V
R
L
RF
A
DGT
LID
S
D
VS
D
V
LP
L
A
-
CD
L
HA
L
T
N
DS
A
V-
VL
LALP
L
A
H
G
N
G
GNL
-
GQG
E
QT
E
R
PL
RY
--
R
QEWQK
V
Q
D
I
Y
GS
DS
E
DMA
V
E
RH
A
L
S
L
R
F
-
-
--
AHDN
NQ
D
YIT
C
PL
A
R
L
V-
R
D
V
Q
G
N
W
T
Q
D
E
G
Y
IP
PL
LA
FN
AH
DG
L
VQR
L
D
TLL
LQ
L
RA
KC
Q
R
L
M
A
MR
R
E
S
N
QRM
ADFAV
ADV
SL
F
WL
L
N
A
LN
S
A
E
PV
LSD
FL
R
YPA
V
HPE
LV
W
R
E
LA
R
L
A
G
A
L
L
TF
S
L
-
-
E
HNVS
A
V
P
-------
P
Y
V
H
E
S
P
ST
V
F
-
P
P
L
F
SLL
S
EL
L
E
AS
L
P
S
R
V
I
A
L
D
L
GSLP
G
N
R
W
---
K
A
D
L
HD
PR
L
RE
E
A
D
F
Y
L
S
V
RS
S
-
L
P
A
H
Q
V
L
H
Q
LPLVC
KI
G
A
P
DDV
TL
L
IN
V
A
L
N
G
V
P
L
EP
L
T
S
V
P
AA
LP
L
R
L
E
NQ
YF
A
LD
M
HSD
A
A
KS
M
LE
S
G
CC
MIY
A
P
G
TMG
DL
K
P
E
L
F
A
V
fig|344601.5.peg.750
Escherichia coli B171 (4-442/445)
HRP
L
W
A
EG
T
F
LS
S
Q
Q
FQQQ
A
R
W
EA
FS
NDS
I
AQ
L
CIRHP
WG
I
A
N
VLF
D
R
DA
L
MS
GK
LKT
Q
A
V
R
L
RF
A
DGT
LID
S
D
VS
D
V
LP
L
A
-
CD
L
HA
L
T
N
DS
A
V-
VL
LALP
L
A
H
G
N
G
GNL
-
GQG
E
QT
E
R
PL
RY
--
R
QEWQK
V
Q
D
I
Y
GS
DS
E
DMA
V
E
RH
A
L
S
L
R
F
-
-
--
AHDN
NQ
D
YIT
C
PL
A
R
L
V-
R
D
V
Q
G
N
W
T
Q
D
E
G
Y
IP
PL
LA
FN
AH
DG
L
VQR
L
D
TLL
LQ
L
RA
KC
Q
R
L
M
A
MR
R
E
S
N
QRM
ADFAV
ADV
SL
F
WL
L
N
A
LN
S
A
E
PV
LSD
FL
R
YPA
V
HPE
LV
W
R
E
LA
R
L
A
G
A
L
L
TF
S
L
-
-
E
HNVS
A
V
P
-------
P
Y
V
H
E
S
P
ST
V
F
-
P
P
L
F
SLL
S
EL
L
E
AS
L
P
S
R
V
I
A
L
D
L
GSLP
G
N
R
W
---
K
A
D
L
HD
PR
L
RE
E
A
D
F
Y
L
S
V
RS
S
-
L
P
A
H
Q
V
L
H
Q
LPLVC
KI
G
A
P
DDV
TL
L
IN
V
A
L
N
G
V
P
L
EP
L
T
S
V
P
AA
LP
L
R
L
E
NQ
YF
A
LD
M
HSD
A
A
KS
M
LE
S
G
CC
MIY
A
P
G
TMG
DL
K
P
E
L
F
A
V
fig|525281.3.peg.4551
Escherichia coli 83972 (7-442/445)
L
W
A
EG
T
F
LS
S
Q
Q
FQQQ
A
R
W
EA
FS
NDS
I
AQ
L
CIRHP
WG
I
A
N
VLF
D
R
DA
L
AL
GK
LKT
Q
A
V
R
L
RF
A
DGT
LID
S
D
VS
D
V
LP
L
A
-
CD
L
RA
L
K
N
DS
A
I-
VL
LALP
L
A
H
G
N
G
GNL
-
GQG
E
QT
E
R
PL
RY
--
R
QEWQK
V
Q
D
I
Y
GS
DS
E
DMA
V
E
RH
A
L
S
L
R
F
-
-
--
AHDN
NQ
D
YIT
C
PL
A
R
L
V-
R
D
V
Q
G
N
W
T
Q
D
E
S
Y
IP
PL
LA
FN
AH
DG
L
VQR
L
D
TLL
LQ
L
RA
KC
Q
R
L
M
A
MR
R
E
S
N
QRM
ADFAV
ADV
SL
F
WL
L
N
A
LN
S
A
E
PV
LSD
FL
R
YPA
V
HPE
LV
W
R
E
LA
R
L
A
G
A
L
L
TF
S
L
-
-
E
HNVS
A
V
P
-------
P
Y
V
H
E
S
P
SI
V
F
-
P
P
L
F
SLL
S
EL
L
E
AS
L
P
S
R
V
I
A
L
D
L
ASLP
G
N
R
W
---
K
A
D
L
HD
PR
L
RE
E
A
D
F
Y
L
S
V
RS
S
-
L
P
A
H
Q
V
L
H
Q
LPLVC
KI
G
A
P
DDV
TL
L
IN
V
A
L
N
G
V
P
L
VP
L
T
S
V
P
AA
LP
L
R
L
E
NQ
YF
A
LD
M
HSD
A
A
KS
M
LE
S
G
CC
MIY
A
P
G
TMG
DL
K
P
E
L
F
A
V
fig|655817.3.peg.3212
Escherichia coli ABU 83972 (7-442/445)
L
W
A
EG
T
F
LS
S
Q
Q
FQQQ
A
R
W
EA
FS
NDS
I
AQ
L
CIRHP
WG
I
A
N
VLF
D
R
DA
L
AL
GK
LKT
Q
A
V
R
L
RF
A
DGT
LID
S
D
VS
D
V
LP
L
A
-
CD
L
RA
L
K
N
DS
A
I-
VL
LALP
L
A
H
G
N
G
GNL
-
GQG
E
QT
E
R
PL
RY
--
R
QEWQK
V
Q
D
I
Y
GS
DS
E
DMA
V
E
RH
A
L
S
L
R
F
-
-
--
AHDN
NQ
D
YIT
C
PL
A
R
L
V-
R
D
V
Q
G
N
W
T
Q
D
E
S
Y
IP
PL
LA
FN
AH
DG
L
VQR
L
D
TLL
LQ
L
RA
KC
Q
R
L
M
A
MR
R
E
S
N
QRM
ADFAV
ADV
SL
F
WL
L
N
A
LN
S
A
E
PV
LSD
FL
R
YPA
V
HPE
LV
W
R
E
LA
R
L
A
G
A
L
L
TF
S
L
-
-
E
HNVS
A
V
P
-------
P
Y
V
H
E
S
P
SI
V
F
-
P
P
L
F
SLL
S
EL
L
E
AS
L
P
S
R
V
I
A
L
D
L
ASLP
G
N
R
W
---
K
A
D
L
HD
PR
L
RE
E
A
D
F
Y
L
S
V
RS
S
-
L
P
A
H
Q
V
L
H
Q
LPLVC
KI
G
A
P
DDV
TL
L
IN
V
A
L
N
G
V
P
L
VP
L
T
S
V
P
AA
LP
L
R
L
E
NQ
YF
A
LD
M
HSD
A
A
KS
M
LE
S
G
CC
MIY
A
P
G
TMG
DL
K
P
E
L
F
A
V
fig|199310.1.peg.3305
Escherichia coli CFT073 (7-442/445)
L
W
A
EG
T
F
LS
S
Q
Q
FQQQ
A
R
W
EA
FS
NDS
I
AQ
L
CIRHP
WG
I
A
N
VLF
D
R
DA
L
AL
GK
LKT
Q
A
V
R
L
RF
A
DGT
LID
S
D
VS
D
V
LP
L
A
-
CD
L
RA
L
K
N
DS
A
I-
VL
LALP
L
A
H
G
N
G
GNL
-
GQG
E
QT
E
R
PL
RY
--
R
QEWQK
V
Q
D
I
Y
GS
DS
E
DMA
V
E
RH
A
L
S
L
R
F
-
-
--
AHDN
NQ
D
YIT
C
PL
A
R
L
V-
R
D
V
Q
G
N
W
T
Q
D
E
S
Y
IP
PL
LA
FN
AH
DG
L
VQR
L
D
TLL
LQ
L
RA
KC
Q
R
L
M
A
MR
R
E
S
N
QRM
ADFAV
ADV
SL
F
WL
L
N
A
LN
S
A
E
PV
LSD
FL
R
YPA
V
HPE
LV
W
R
E
LA
R
L
A
G
A
L
L
TF
S
L
-
-
E
HNVS
A
V
P
-------
P
Y
V
H
E
S
P
SI
V
F
-
P
P
L
F
SLL
S
EL
L
E
AS
L
P
S
R
V
I
A
L
D
L
ASLP
G
N
R
W
---
K
A
D
L
HD
PR
L
RE
E
A
D
F
Y
L
S
V
RS
S
-
L
P
A
H
Q
V
L
H
Q
LPLVC
KI
G
A
P
DDV
TL
L
IN
V
A
L
N
G
V
P
L
VP
L
T
S
V
P
AA
LP
L
R
L
E
NQ
YF
A
LD
M
HSD
A
A
KS
M
LE
S
G
CC
MIY
A
P
G
TMG
DL
K
P
E
L
F
A
V
fig|199310.4.peg.3189
Escherichia coli CFT073 (7-442/445)
L
W
A
EG
T
F
LS
S
Q
Q
FQQQ
A
R
W
EA
FS
NDS
I
AQ
L
CIRHP
WG
I
A
N
VLF
D
R
DA
L
AL
GK
LKT
Q
A
V
R
L
RF
A
DGT
LID
S
D
VS
D
V
LP
L
A
-
CD
L
RA
L
K
N
DS
A
I-
VL
LALP
L
A
H
G
N
G
GNL
-
GQG
E
QT
E
R
PL
RY
--
R
QEWQK
V
Q
D
I
Y
GS
DS
E
DMA
V
E
RH
A
L
S
L
R
F
-
-
--
AHDN
NQ
D
YIT
C
PL
A
R
L
V-
R
D
V
Q
G
N
W
T
Q
D
E
S
Y
IP
PL
LA
FN
AH
DG
L
VQR
L
D
TLL
LQ
L
RA
KC
Q
R
L
M
A
MR
R
E
S
N
QRM
ADFAV
ADV
SL
F
WL
L
N
A
LN
S
A
E
PV
LSD
FL
R
YPA
V
HPE
LV
W
R
E
LA
R
L
A
G
A
L
L
TF
S
L
-
-
E
HNVS
A
V
P
-------
P
Y
V
H
E
S
P
SI
V
F
-
P
P
L
F
SLL
S
EL
L
E
AS
L
P
S
R
V
I
A
L
D
L
ASLP
G
N
R
W
---
K
A
D
L
HD
PR
L
RE
E
A
D
F
Y
L
S
V
RS
S
-
L
P
A
H
Q
V
L
H
Q
LPLVC
KI
G
A
P
DDV
TL
L
IN
V
A
L
N
G
V
P
L
VP
L
T
S
V
P
AA
LP
L
R
L
E
NQ
YF
A
LD
M
HSD
A
A
KS
M
LE
S
G
CC
MIY
A
P
G
TMG
DL
K
P
E
L
F
A
V
fig|749546.3.peg.3096
Escherichia coli MS 185-1 (7-442/445)
L
W
A
EG
T
F
LS
S
Q
Q
FQQQ
A
R
W
EA
FS
NDS
I
AQ
L
CIRHP
WG
I
A
N
VLF
D
R
DA
L
AL
GK
LKT
Q
A
V
R
L
RF
A
DGT
LID
S
D
VS
D
V
LP
L
A
-
CD
L
RA
L
K
N
DS
A
I-
VL
LALP
L
A
H
G
N
G
GNL
-
GQG
E
QT
E
R
PL
RY
--
R
QEWQK
V
Q
D
I
Y
GS
DS
E
DMA
V
E
RH
A
L
S
L
R
F
-
-
--
AHDN
NQ
D
YIT
C
PL
A
R
L
V-
R
D
V
Q
G
N
W
T
Q
D
E
S
Y
IP
PL
LA
FN
AH
DG
L
VQR
L
D
TLL
LQ
L
RA
KC
Q
R
L
M
A
MR
R
E
S
N
QRM
ADFAV
ADV
SL
F
WL
L
N
A
LN
S
A
E
PV
LSD
FL
R
YPA
V
HPE
LV
W
R
E
LA
R
L
A
G
A
L
L
TF
S
L
-
-
E
HNVS
A
V
P
-------
P
Y
V
H
E
S
P
SI
V
F
-
P
P
L
F
SLL
S
EL
L
E
AS
L
P
S
R
V
I
A
L
D
L
ASLP
G
N
R
W
---
K
A
D
L
HD
PR
L
RE
E
A
D
F
Y
L
S
V
RS
S
-
L
P
A
H
Q
V
L
H
Q
LPLVC
KI
G
A
P
DDV
TL
L
IN
V
A
L
N
G
V
P
L
VP
L
T
S
V
P
AA
LP
L
R
L
E
NQ
YF
A
LD
M
HSD
A
A
KS
M
LE
S
G
CC
MIY
A
P
G
TMG
DL
K
P
E
L
F
A
V
fig|749528.3.peg.2050
Escherichia coli MS 45-1 (7-442/445)
L
W
A
EG
T
F
LS
S
Q
Q
FQQQ
A
R
W
EA
FS
NDS
I
AQ
L
CIRHP
WG
I
A
N
VLF
D
R
DA
L
AL
GK
LKT
Q
A
V
R
L
RF
A
DGT
LID
S
D
VS
D
V
LP
L
A
-
CD
L
RA
L
K
N
DS
A
I-
VL
LALP
L
A
H
G
N
G
GNL
-
GQG
E
QT
E
R
PL
RY
--
R
QEWQK
V
Q
D
I
Y
GS
DS
E
DMA
V
E
RH
A
L
S
L
R
F
-
-
--
AHDN
NQ
D
YIT
C
PL
A
R
L
V-
R
D
V
Q
G
N
W
T
Q
D
E
S
Y
IP
PL
LA
FN
AH
DG
L
VQR
L
D
TLL
LQ
L
RA
KC
Q
R
L
M
A
MR
R
E
S
N
QRM
ADFAV
ADV
SL
F
WL
L
N
A
LN
S
A
E
PV
LSD
FL
R
YPA
V
HPE
LV
W
R
E
LA
R
L
A
G
A
L
L
TF
S
L
-
-
E
HNVS
A
V
P
-------
P
Y
V
H
E
S
P
SI
V
F
-
P
P
L
F
SLL
S
EL
L
E
AS
L
P
S
R
V
I
A
L
D
L
ASLP
G
N
R
W
---
K
A
D
L
HD
PR
L
RE
E
A
D
F
Y
L
S
V
RS
S
-
L
P
A
H
Q
V
L
H
Q
LPLVC
KI
G
A
P
DDV
TL
L
IN
V
A
L
N
G
V
P
L
VP
L
T
S
V
P
AA
LP
L
R
L
E
NQ
YF
A
LD
M
HSD
A
A
KS
M
LE
S
G
CC
MIY
A
P
G
TMG
DL
K
P
E
L
F
A
V
fig|656417.3.peg.3573
Escherichia coli M605 (4-442/445)
HRP
L
W
A
EG
T
F
LS
S
Q
Q
FQQQ
A
R
W
EA
FS
NDS
I
AQ
L
CIRHP
WG
I
A
N
VLF
D
R
DA
L
TS
GK
LKT
Q
A
V
R
L
RF
A
DGT
LID
S
D
VS
D
V
LP
L
A
-
CD
L
RA
L
K
N
DS
A
I-
VL
LALP
L
A
H
G
N
G
GNL
-
GQG
E
QT
E
R
PL
RY
--
R
QEWQK
V
Q
D
I
Y
GS
DS
E
DMA
V
E
RH
A
L
S
L
R
F
-
-
--
AHDN
NQ
D
YIT
C
PL
A
R
L
V-
R
D
V
Q
G
N
W
T
Q
D
E
S
Y
IP
PL
LA
FN
AH
DG
L
VQR
L
D
TLL
LQ
L
RA
KC
Q
R
L
M
A
MR
R
E
S
N
QRM
ADFAV
ADV
SL
F
WL
L
N
A
LN
S
A
E
PV
LSD
FL
R
YPA
V
HPE
LV
W
R
E
LA
R
L
A
G
A
L
L
TF
S
L
-
-
E
HNVS
A
V
P
-------
P
Y
V
H
E
S
P
SI
V
F
-
P
P
L
F
SLL
S
EL
L
E
AS
L
P
S
R
V
I
A
L
D
L
ASLP
G
N
R
W
---
K
A
D
L
HD
PR
L
RE
E
A
D
F
Y
L
S
V
RS
S
-
L
P
A
H
Q
V
L
H
Q
LPLVC
KI
G
A
P
DDV
TL
L
IN
V
A
L
N
G
V
P
L
VP
L
T
S
V
P
AA
LP
L
R
L
E
NQ
YF
A
LD
M
HSD
A
A
KS
M
LE
S
G
CC
MIY
A
P
G
TMG
DL
K
P
E
L
F
A
V
fig|431946.3.peg.2732
Escherichia coli SE15 (4-442/445)
HRP
L
W
A
EG
T
F
LS
S
Q
Q
FQQQ
A
R
W
EA
FS
NDS
I
AQ
L
CIRHP
WG
I
A
N
VLF
D
R
DA
L
TS
GK
LKT
Q
A
V
R
L
RF
A
DGT
LID
S
D
VS
D
V
LP
L
A
-
CD
L
RA
L
K
N
DS
A
I-
VL
LALP
L
A
H
G
N
G
GNL
-
GQG
E
QT
E
R
PL
RY
--
R
QEWQK
V
Q
D
I
Y
GS
DS
E
DMA
V
E
RH
A
L
S
L
R
F
-
-
--
AHDN
NQ
D
YIT
C
PL
A
R
L
V-
R
D
V
Q
G
N
W
T
Q
D
E
S
Y
IP
PL
LA
FN
AH
DG
L
VQR
L
D
TLL
LQ
L
RA
KC
Q
R
L
M
A
MR
R
E
S
N
QRM
ADFAV
ADV
SL
F
WL
L
N
A
LN
S
A
E
PV
LSD
FL
R
YPA
V
HPE
LV
W
R
E
LA
R
L
A
G
A
L
L
TF
S
L
-
-
E
HNVS
A
V
P
-------
P
Y
V
H
E
S
P
SI
V
F
-
P
P
L
F
SLL
S
EL
L
E
AS
L
P
S
R
V
I
A
L
D
L
ASLP
G
N
R
W
---
K
A
D
L
HD
PR
L
RE
E
A
D
F
Y
L
S
V
RS
S
-
L
P
A
H
Q
V
L
H
Q
LPLVC
KI
G
A
P
DDV
TL
L
IN
V
A
L
N
G
V
P
L
VP
L
T
S
V
P
AA
LP
L
R
L
E
NQ
YF
A
LD
M
HSD
A
A
KS
M
LE
S
G
CC
MIY
A
P
G
TMG
DL
K
P
E
L
F
A
V
fig|679204.3.peg.3993
Escherichia coli MS 145-7 (4-442/445)
HRP
L
W
A
EG
T
F
LS
S
Q
Q
FQQQ
A
R
W
EA
FS
NDS
I
AQ
L
CIRHP
WG
I
A
N
VLF
D
R
DA
L
MS
GK
LKT
Q
A
V
R
L
RF
A
DGT
LID
S
D
VS
D
V
LP
L
A
-
CD
L
HA
L
T
N
DS
A
V-
VL
LALP
L
A
H
G
N
G
GNL
-
GQG
E
QT
E
R
PL
RY
--
R
QEWQK
V
Q
D
I
Y
GS
DS
E
DMA
V
E
RH
A
L
S
L
R
F
-
-
--
AHDN
NQ
D
YIT
C
PL
A
R
L
V-
R
D
V
Q
G
N
W
T
Q
D
E
G
Y
IP
PL
LA
FN
AH
DG
L
VQR
L
D
TLL
LQ
L
RA
KC
Q
R
L
M
A
MR
R
E
S
N
QRM
ADFAV
ADV
SL
F
WL
L
N
A
LN
S
A
E
PV
LSD
FL
R
YPA
V
HPE
LV
W
R
E
LA
R
L
A
G
A
L
L
TF
S
L
-
-
E
HNVS
A
V
P
-------
P
Y
V
H
E
S
P
ST
V
F
-
P
P
L
F
SLL
S
EL
L
E
AS
L
P
S
R
V
I
A
L
D
L
GSLP
G
N
R
W
---
K
A
D
L
HD
PR
L
RE
E
A
D
F
Y
L
S
V
RS
S
-
L
P
A
H
Q
V
L
H
Q
LPLVC
KI
G
A
P
DDV
TL
L
IN
V
A
L
N
G
V
P
L
VP
L
T
S
V
P
AA
LP
L
R
L
E
NQ
YF
A
LD
M
HSD
A
A
KS
M
LE
S
G
CC
MIY
T
P
G
TMG
DL
K
P
E
L
F
A
V
fig|585395.4.peg.3518
Escherichia coli O103:H2 str. 12009 (4-442/445)
HRP
L
W
A
EG
T
F
LS
S
Q
Q
FQQQ
A
R
W
EA
FS
NDS
I
AQ
L
CIRHP
WG
I
A
N
VLF
D
R
DA
L
MS
GK
LKT
Q
A
V
R
L
RF
A
DGT
LID
S
D
VS
D
V
LP
L
A
-
CD
L
HA
L
T
N
DS
A
V-
VL
LALP
L
A
H
G
N
G
GNL
-
GQG
E
QT
E
R
PL
RY
--
R
QEWQK
V
Q
D
I
Y
GS
DS
E
DMA
V
E
RH
A
L
S
L
R
F
-
-
--
AHDN
NQ
D
YIT
C
PL
A
R
L
V-
R
D
V
Q
G
N
W
T
Q
D
E
G
Y
IP
PL
LA
FN
AH
DG
L
VQR
L
D
TLL
LQ
L
RA
KC
Q
R
L
M
A
MR
R
E
S
N
QRM
ADFAV
ADV
SL
F
WL
L
N
A
LN
S
A
E
PV
LSD
FL
R
YPA
V
HPE
LV
W
R
E
LA
R
L
A
G
A
L
L
TF
S
L
-
-
E
HNVS
A
V
P
-------
P
Y
V
H
E
S
P
ST
V
F
-
P
P
L
F
SLL
S
EL
L
E
AS
L
P
S
R
V
I
A
L
D
L
GSLP
G
N
R
W
---
K
A
D
L
HD
PR
L
RE
E
A
D
F
Y
L
S
V
RS
S
-
L
P
A
H
Q
V
L
H
Q
LPLVC
KI
G
A
P
DDV
TL
L
IN
V
A
L
N
G
V
P
L
VP
L
T
S
V
P
AA
LP
L
R
L
E
NQ
YF
A
LD
M
HSD
A
A
KS
M
LE
S
G
CC
MIY
A
P
G
TMG
DL
K
P
E
L
F
A
V
fig|656393.3.peg.3819
Escherichia coli H299 (7-442/445)
L
W
A
EG
T
F
LS
S
Q
Q
FQQQ
A
R
W
EA
FS
NDS
I
AQ
L
CIRHP
WG
I
A
N
VLF
D
R
DA
L
TP
GK
LKT
Q
A
V
R
L
RF
A
DGT
LID
S
D
VA
D
I
LP
P
A
-
CD
L
RT
L
E
G
GS
A
I-
VL
LALP
L
A
H
G
N
G
GNL
-
GQG
E
QA
E
R
PL
RY
--
R
QEWQK
V
Q
D
I
Y
GS
DS
E
DMA
V
E
RH
A
L
S
L
R
F
-
-
--
AHDN
NQ
D
YIT
C
PL
A
R
L
V-
R
D
V
Q
G
N
W
T
Q
D
E
S
Y
IP
PL
LA
FN
AH
DG
L
VQR
L
D
TLL
LQ
L
RA
KC
Q
R
L
M
A
MR
R
E
S
N
QRM
ADFAV
ADV
SL
F
WL
L
N
A
LN
S
A
E
PV
LSD
FL
R
YPA
V
HPE
LV
W
R
E
LA
R
L
A
G
A
L
L
TF
S
L
-
-
E
HNVS
A
V
P
-------
P
Y
V
H
E
S
P
ST
V
F
-
P
P
L
F
SLL
S
EL
L
E
AS
L
P
S
R
V
I
A
L
D
L
ASLP
G
N
R
W
---
K
A
D
L
HD
PR
L
RE
E
A
D
F
Y
L
S
V
RS
S
-
L
P
A
H
Q
V
L
H
Q
LPLVC
KI
G
A
P
DDV
TL
L
IN
V
A
L
N
G
V
P
L
VP
L
T
S
V
P
AA
LP
L
R
L
E
NQ
YF
A
LD
M
HSD
A
A
KS
M
LE
S
G
SC
MIY
A
P
G
TMG
DL
K
P
E
L
F
A
V
fig|340185.3.peg.3497
Escherichia coli E22 (4-442/445)
HRP
L
W
A
EG
T
F
LS
S
Q
Q
FQQQ
A
R
W
EA
F
N
NDS
I
AQ
L
CIRHP
WG
I
A
N
VLF
D
R
DA
L
MS
GK
LKT
Q
A
V
R
L
RF
A
DGT
LID
S
D
VS
D
V
LP
L
A
-
CD
L
HA
L
T
N
DS
A
V-
VL
LALP
L
A
H
G
N
G
GNL
-
GQG
E
QT
E
R
PL
RY
--
R
QEWQK
V
Q
D
I
Y
GS
DS
E
DMA
V
E
RH
A
L
S
L
R
F
-
-
--
AHDN
NQ
D
YIT
C
PL
A
R
L
V-
R
D
V
Q
G
N
W
T
Q
D
E
G
Y
IP
PL
LA
FN
AH
DG
L
VQR
L
D
TLL
LQ
L
RA
KC
Q
R
L
M
A
MR
R
E
S
N
QRM
ADFAV
ADV
SL
F
WL
L
N
A
LN
S
A
E
PV
LSD
FL
R
YPA
V
HPE
LV
W
R
E
LA
R
L
A
G
A
L
L
TF
S
L
-
-
E
HNVS
A
V
P
-------
P
Y
V
H
E
S
P
ST
V
F
-
P
P
L
F
SLL
S
EL
L
E
AS
L
P
S
R
V
I
A
L
D
L
GSLP
G
N
R
W
---
K
A
D
L
HD
PR
L
RE
E
A
D
F
Y
L
S
V
RS
S
-
L
P
A
H
Q
V
L
H
Q
LPLVC
KI
G
A
P
DDV
TL
L
IN
V
A
L
N
G
V
P
L
VP
L
T
S
V
P
AA
LP
L
R
L
E
NQ
YF
A
LD
M
HSD
A
A
KS
M
LE
S
G
CC
MIY
A
P
G
TMG
DL
K
P
E
L
F
A
V
fig|340185.4.peg.3679
Escherichia coli E22 (4-442/445)
HRP
L
W
A
EG
T
F
LS
S
Q
Q
FQQQ
A
R
W
EA
F
N
NDS
I
AQ
L
CIRHP
WG
I
A
N
VLF
D
R
DA
L
MS
GK
LKT
Q
A
V
R
L
RF
A
DGT
LID
S
D
VS
D
V
LP
L
A
-
CD
L
HA
L
T
N
DS
A
V-
VL
LALP
L
A
H
G
N
G
GNL
-
GQG
E
QT
E
R
PL
RY
--
R
QEWQK
V
Q
D
I
Y
GS
DS
E
DMA
V
E
RH
A
L
S
L
R
F
-
-
--
AHDN
NQ
D
YIT
C
PL
A
R
L
V-
R
D
V
Q
G
N
W
T
Q
D
E
G
Y
IP
PL
LA
FN
AH
DG
L
VQR
L
D
TLL
LQ
L
RA
KC
Q
R
L
M
A
MR
R
E
S
N
QRM
ADFAV
ADV
SL
F
WL
L
N
A
LN
S
A
E
PV
LSD
FL
R
YPA
V
HPE
LV
W
R
E
LA
R
L
A
G
A
L
L
TF
S
L
-
-
E
HNVS
A
V
P
-------
P
Y
V
H
E
S
P
ST
V
F
-
P
P
L
F
SLL
S
EL
L
E
AS
L
P
S
R
V
I
A
L
D
L
GSLP
G
N
R
W
---
K
A
D
L
HD
PR
L
RE
E
A
D
F
Y
L
S
V
RS
S
-
L
P
A
H
Q
V
L
H
Q
LPLVC
KI
G
A
P
DDV
TL
L
IN
V
A
L
N
G
V
P
L
VP
L
T
S
V
P
AA
LP
L
R
L
E
NQ
YF
A
LD
M
HSD
A
A
KS
M
LE
S
G
CC
MIY
A
P
G
TMG
DL
K
P
E
L
F
A
V
fig|685038.3.peg.2814
Escherichia coli O83:H1 str. NRG 857C (7-442/445)
L
W
A
EG
T
F
LS
S
Q
Q
FQQQ
A
R
W
EA
FS
NDC
I
AQ
L
CIRHP
WG
I
A
N
VLF
D
R
DA
L
TP
GK
LKT
Q
A
V
R
L
RF
A
DGT
LID
S
D
VS
D
V
LP
L
A
-
CD
L
RA
L
K
N
DS
A
I-
VL
LALP
L
A
H
G
N
G
GNL
-
GQG
E
QT
E
R
PL
RY
--
R
QEWQK
V
Q
D
I
Y
GS
DS
E
DMA
V
E
RH
A
L
S
L
R
F
-
-
--
AHDN
NQ
D
YIT
C
PL
A
R
L
V-
R
D
V
Q
G
N
W
T
Q
D
E
S
Y
IP
PL
LA
FN
AH
DG
L
VQR
L
D
TLL
LQ
L
RA
KC
Q
R
L
M
A
MR
R
E
S
N
QRM
ADFAV
ADV
SL
F
WL
L
N
A
LN
S
A
E
PV
LSD
FL
R
YPA
V
HPE
LV
W
R
E
LA
R
L
A
G
A
L
L
TF
S
L
-
-
E
HNVS
A
V
P
-------
P
Y
V
H
E
S
P
SI
V
F
-
P
P
L
F
SLL
S
EL
L
E
AS
L
P
S
R
V
I
A
L
D
L
ASLP
G
N
R
W
---
K
A
D
L
HD
PR
L
RE
E
A
D
F
Y
L
S
V
RS
S
-
L
P
A
H
Q
V
L
H
Q
LPLVC
KI
G
A
P
DDV
TL
L
IN
V
A
L
N
G
V
P
L
VP
L
T
S
V
P
AA
LP
L
R
L
E
NQ
YF
A
LD
M
HSD
A
A
KS
M
LE
S
G
SC
MIY
A
P
G
TMG
DL
K
P
E
L
F
A
V
fig|340184.3.peg.4555
Escherichia coli B7A (4-442/445)
HRP
L
W
A
EG
T
F
LS
S
Q
Q
FQQQ
A
R
W
EA
FS
NDS
I
AQ
L
CIRHP
WG
I
A
N
VLF
D
R
DA
L
MS
GK
LKT
Q
A
V
R
L
RF
A
DGT
LID
S
D
VS
D
V
LP
L
A
-
CD
L
HA
L
T
N
DS
A
V-
VL
LALP
L
A
H
G
N
G
GNL
-
GQG
E
QT
E
R
PL
RY
--
R
QEWQK
V
Q
D
I
Y
GS
DS
E
DMA
V
E
RH
A
L
S
L
R
F
-
-
--
AHDN
NQ
D
YIT
C
PL
A
R
L
V-
R
D
V
Q
G
N
W
T
Q
D
E
G
Y
IP
PL
LA
FN
AH
DG
L
VQR
L
D
TLL
LQ
L
RA
KC
Q
R
L
M
A
MR
R
E
S
N
QRM
ADFAV
ADV
SL
F
WL
L
N
A
LN
S
A
E
PV
LSD
FL
R
YPA
V
HPE
LV
R
R
E
LA
R
L
A
G
A
L
L
TF
S
L
-
-
E
HNVS
A
V
P
-------
P
Y
V
H
E
S
P
ST
V
F
-
P
P
L
F
SLL
S
EL
L
E
AS
L
P
S
R
V
I
A
L
D
L
GSLP
G
N
R
W
---
K
A
D
L
HD
PR
L
RE
E
A
D
F
Y
L
S
V
RS
S
-
L
P
A
H
Q
V
L
H
Q
LPLVC
KI
G
A
P
DDV
TL
L
IN
V
A
L
N
G
V
P
L
VP
L
T
S
V
P
AA
LP
L
R
L
E
NQ
YF
A
LD
M
HSD
A
A
KS
M
LE
S
G
CC
MIY
A
P
G
TMG
DL
K
P
E
L
F
A
V
fig|340184.6.peg.4780
Escherichia coli B7A (4-442/445)
HRP
L
W
A
EG
T
F
LS
S
Q
Q
FQQQ
A
R
W
EA
FS
NDS
I
AQ
L
CIRHP
WG
I
A
N
VLF
D
R
DA
L
MS
GK
LKT
Q
A
V
R
L
RF
A
DGT
LID
S
D
VS
D
V
LP
L
A
-
CD
L
HA
L
T
N
DS
A
V-
VL
LALP
L
A
H
G
N
G
GNL
-
GQG
E
QT
E
R
PL
RY
--
R
QEWQK
V
Q
D
I
Y
GS
DS
E
DMA
V
E
RH
A
L
S
L
R
F
-
-
--
AHDN
NQ
D
YIT
C
PL
A
R
L
V-
R
D
V
Q
G
N
W
T
Q
D
E
G
Y
IP
PL
LA
FN
AH
DG
L
VQR
L
D
TLL
LQ
L
RA
KC
Q
R
L
M
A
MR
R
E
S
N
QRM
ADFAV
ADV
SL
F
WL
L
N
A
LN
S
A
E
PV
LSD
FL
R
YPA
V
HPE
LV
R
R
E
LA
R
L
A
G
A
L
L
TF
S
L
-
-
E
HNVS
A
V
P
-------
P
Y
V
H
E
S
P
ST
V
F
-
P
P
L
F
SLL
S
EL
L
E
AS
L
P
S
R
V
I
A
L
D
L
GSLP
G
N
R
W
---
K
A
D
L
HD
PR
L
RE
E
A
D
F
Y
L
S
V
RS
S
-
L
P
A
H
Q
V
L
H
Q
LPLVC
KI
G
A
P
DDV
TL
L
IN
V
A
L
N
G
V
P
L
VP
L
T
S
V
P
AA
LP
L
R
L
E
NQ
YF
A
LD
M
HSD
A
A
KS
M
LE
S
G
CC
MIY
A
P
G
TMG
DL
K
P
E
L
F
A
V
fig|656440.3.peg.2841
Escherichia coli TA206 (4-442/445)
HRP
L
W
A
EG
T
F
LS
S
Q
Q
FQQQ
A
R
W
EA
FS
NDC
I
AQ
L
CIRHP
WG
I
A
N
VLF
D
R
DA
L
TP
GK
LKT
Q
A
V
R
L
RF
A
DGT
LID
S
D
VS
D
V
LP
L
A
-
CD
L
RA
L
K
N
DS
A
I-
VL
LALP
L
A
H
G
N
G
GNL
-
GQG
E
QT
E
R
PL
RY
--
R
QEWQK
V
Q
D
I
Y
GS
DS
E
DMA
V
E
RH
A
L
S
L
R
F
-
-
--
AHDN
NQ
D
YIT
C
PL
A
R
L
V-
R
D
V
Q
G
N
W
T
Q
D
E
S
Y
IP
PL
LA
FN
AH
DG
L
VQR
L
D
TLL
LQ
L
RA
KC
Q
R
L
M
A
MR
R
E
S
N
QRM
ADFAV
ADV
SL
F
WL
L
N
A
LN
S
A
E
PV
LSD
FL
R
YPA
V
HPE
LV
W
R
E
LA
R
L
A
G
A
L
L
TF
S
L
-
-
E
HNVS
A
V
P
-------
P
Y
V
H
E
S
P
SI
V
F
-
P
P
L
F
SLL
S
EL
L
E
AS
L
P
S
R
V
I
A
L
D
L
ASLP
G
N
R
W
---
K
A
D
L
HD
PR
L
RE
E
A
D
F
Y
L
S
V
RS
S
-
L
P
A
H
Q
V
L
H
Q
LPLVC
KI
G
A
P
DDV
TL
L
IN
V
A
L
N
G
V
P
L
VP
L
T
S
V
P
AA
LP
L
R
L
E
NQ
YF
A
LD
M
HSD
A
A
KS
M
LE
S
G
CC
MIY
A
P
G
TMG
DL
K
P
E
L
F
A
V
fig|595495.4.peg.2568
Escherichia coli KO11 (4-442/445)
HRP
L
W
A
EG
T
F
LS
S
Q
Q
FQQQ
A
R
W
EA
FS
NDS
I
AQ
L
CIRHP
WG
I
A
N
VLF
D
R
DA
L
MS
GK
LKT
Q
A
V
R
L
RF
A
DGT
LID
S
D
VS
D
V
LP
L
A
-
CD
L
HA
L
T
N
DS
A
V-
VL
LALP
L
A
H
G
N
G
GNL
-
GQG
E
QT
E
R
PL
RY
--
R
QEWQK
V
Q
D
I
Y
GS
DS
E
DMA
V
E
RH
A
L
S
L
R
F
-
-
--
AHDN
NQ
D
YIT
C
PL
A
R
L
V-
R
D
V
Q
G
N
W
T
Q
D
E
S
Y
IP
PL
LA
FN
AH
DG
L
VQR
L
D
TLL
LQ
L
RA
KC
Q
R
L
M
A
MR
R
E
S
N
QRM
ADFAV
ADV
SL
F
WL
L
N
A
LN
S
A
E
PV
LSD
FL
R
YPA
V
HPE
LV
W
R
E
LA
R
L
A
G
A
L
L
TF
S
L
-
-
E
HNVS
A
V
P
-------
P
Y
V
H
E
S
P
ST
V
F
-
P
P
L
F
SLL
S
EL
L
E
AS
L
P
S
R
V
I
A
L
E
L
GSLP
G
N
R
W
---
K
A
D
L
HD
PR
L
RE
E
A
D
F
Y
L
S
V
RS
S
-
L
P
A
H
Q
V
L
H
Q
LPLVC
KI
G
A
P
DDV
TL
L
IN
V
A
L
N
G
V
S
L
VP
L
T
S
V
P
AA
LP
L
R
L
E
NQ
YF
A
LD
M
HSD
A
A
KS
M
LE
S
G
CC
MIY
A
P
G
TMG
DL
K
P
E
L
F
A
V
fig|566546.3.peg.2879
Escherichia coli W (4-442/445)
HRP
L
W
A
EG
T
F
LS
S
Q
Q
FQQQ
A
R
W
EA
FS
NDS
I
AQ
L
CIRHP
WG
I
A
N
VLF
D
R
DA
L
MS
GK
LKT
Q
A
V
R
L
RF
A
DGT
LID
S
D
VS
D
V
LP
L
A
-
CD
L
HA
L
T
N
DS
A
V-
VL
LALP
L
A
H
G
N
G
GNL
-
GQG
E
QT
E
R
PL
RY
--
R
QEWQK
V
Q
D
I
Y
GS
DS
E
DMA
V
E
RH
A
L
S
L
R
F
-
-
--
AHDN
NQ
D
YIT
C
PL
A
R
L
V-
R
D
V
Q
G
N
W
T
Q
D
E
S
Y
IP
PL
LA
FN
AH
DG
L
VQR
L
D
TLL
LQ
L
RA
KC
Q
R
L
M
A
MR
R
E
S
N
QRM
ADFAV
ADV
SL
F
WL
L
N
A
LN
S
A
E
PV
LSD
FL
R
YPA
V
HPE
LV
W
R
E
LA
R
L
A
G
A
L
L
TF
S
L
-
-
E
HNVS
A
V
P
-------
P
Y
V
H
E
S
P
ST
V
F
-
P
P
L
F
SLL
S
EL
L
E
AS
L
P
S
R
V
I
A
L
E
L
GSLP
G
N
R
W
---
K
A
D
L
HD
PR
L
RE
E
A
D
F
Y
L
S
V
RS
S
-
L
P
A
H
Q
V
L
H
Q
LPLVC
KI
G
A
P
DDV
TL
L
IN
V
A
L
N
G
V
S
L
VP
L
T
S
V
P
AA
LP
L
R
L
E
NQ
YF
A
LD
M
HSD
A
A
KS
M
LE
S
G
CC
MIY
A
P
G
TMG
DL
K
P
E
L
F
A
V
fig|566546.4.peg.2995
Escherichia coli W (4-442/445)
HRP
L
W
A
EG
T
F
LS
S
Q
Q
FQQQ
A
R
W
EA
FS
NDS
I
AQ
L
CIRHP
WG
I
A
N
VLF
D
R
DA
L
MS
GK
LKT
Q
A
V
R
L
RF
A
DGT
LID
S
D
VS
D
V
LP
L
A
-
CD
L
HA
L
T
N
DS
A
V-
VL
LALP
L
A
H
G
N
G
GNL
-
GQG
E
QT
E
R
PL
RY
--
R
QEWQK
V
Q
D
I
Y
GS
DS
E
DMA
V
E
RH
A
L
S
L
R
F
-
-
--
AHDN
NQ
D
YIT
C
PL
A
R
L
V-
R
D
V
Q
G
N
W
T
Q
D
E
S
Y
IP
PL
LA
FN
AH
DG
L
VQR
L
D
TLL
LQ
L
RA
KC
Q
R
L
M
A
MR
R
E
S
N
QRM
ADFAV
ADV
SL
F
WL
L
N
A
LN
S
A
E
PV
LSD
FL
R
YPA
V
HPE
LV
W
R
E
LA
R
L
A
G
A
L
L
TF
S
L
-
-
E
HNVS
A
V
P
-------
P
Y
V
H
E
S
P
ST
V
F
-
P
P
L
F
SLL
S
EL
L
E
AS
L
P
S
R
V
I
A
L
E
L
GSLP
G
N
R
W
---
K
A
D
L
HD
PR
L
RE
E
A
D
F
Y
L
S
V
RS
S
-
L
P
A
H
Q
V
L
H
Q
LPLVC
KI
G
A
P
DDV
TL
L
IN
V
A
L
N
G
V
S
L
VP
L
T
S
V
P
AA
LP
L
R
L
E
NQ
YF
A
LD
M
HSD
A
A
KS
M
LE
S
G
CC
MIY
A
P
G
TMG
DL
K
P
E
L
F
A
V
fig|362663.9.peg.2843
Escherichia coli 536 (4-442/445)
HRP
L
W
A
EG
T
F
LS
S
Q
Q
FQQQ
A
R
W
EA
FS
NDC
I
AQ
L
CIRHP
WG
I
A
N
VLF
D
R
DA
L
TP
GK
LKT
Q
A
V
R
L
RF
A
DGT
LID
S
D
VS
D
V
LP
L
A
-
CD
L
RA
L
K
N
DS
A
I-
VL
LALP
L
A
H
G
N
G
GNL
-
GQG
E
QT
E
R
PL
RY
--
R
QEWQK
V
Q
D
I
Y
GS
DS
E
DMA
V
E
RH
A
L
S
L
R
F
-
-
--
AHDN
NQ
D
YIT
C
PL
A
R
L
V-
R
D
V
Q
G
N
W
T
Q
D
E
S
Y
IP
PL
LA
FN
AH
DG
L
VQR
L
D
TLL
LQ
L
RA
KC
Q
R
L
M
A
MR
R
E
S
N
QRM
ADFAV
ADV
SL
F
WL
L
N
A
LN
S
A
E
PV
LSD
FL
R
YPA
V
HPE
LV
W
R
E
LA
R
L
A
G
A
L
L
TF
S
L
-
-
E
HNVS
A
V
P
-------
P
Y
V
H
E
S
P
ST
V
F
-
P
P
L
F
SLL
S
EL
L
E
AS
L
P
S
R
V
I
A
L
D
L
ASLP
G
N
R
W
---
K
A
D
L
HD
PR
L
RE
E
A
D
F
Y
L
S
V
RS
S
-
L
P
A
H
Q
V
L
H
Q
LPLVC
KI
G
A
P
DDV
TL
L
IN
V
A
L
N
G
V
Q
L
VP
L
T
S
V
P
AA
LP
L
R
L
E
NQ
YF
A
LD
M
HSD
A
A
KS
M
LE
S
G
SC
MIY
A
P
G
TMG
DL
K
P
E
L
F
A
V
fig|405955.13.peg.3128
Escherichia coli APEC O1 (4-442/445)
HRP
L
W
A
EG
T
F
LS
S
Q
Q
FQQQ
A
R
W
EA
FS
NDC
I
AQ
L
CIRHP
WG
I
A
N
VLF
D
R
DA
L
TP
GK
LKT
Q
A
V
R
L
RF
A
DGT
LID
S
D
VS
D
V
LP
L
A
-
CD
L
RA
L
K
N
DS
A
I-
VL
LALP
L
A
H
G
N
G
GNL
-
GQG
E
QT
E
R
PL
RY
--
R
QEWQK
V
Q
D
I
Y
GS
DS
E
DMA
V
E
RH
A
L
S
L
R
F
-
-
--
AHDN
NQ
D
YIT
C
PL
A
R
L
V-
R
D
V
Q
G
N
W
T
Q
D
E
S
Y
IP
PL
LA
FN
AH
DG
L
VQR
L
D
TLL
LQ
L
RA
KC
Q
R
L
M
A
MR
R
E
S
N
QRM
ADFAV
ADV
SL
F
WL
L
N
A
LN
S
A
E
PV
LSD
FL
R
YPA
V
HPE
LV
W
R
E
LA
R
L
A
G
A
L
L
TF
S
L
-
-
E
HNVS
A
V
P
-------
P
Y
V
H
E
S
P
ST
V
F
-
P
P
L
F
SLL
S
EL
L
E
AS
L
P
S
R
V
I
A
L
D
L
ASLP
G
N
R
W
---
K
A
D
L
HD
PR
L
RE
E
A
D
F
Y
L
S
V
RS
S
-
L
P
A
H
Q
V
L
H
Q
LPLVC
KI
G
A
P
DDV
TL
L
IN
V
A
L
N
G
V
Q
L
VP
L
T
S
V
P
AA
LP
L
R
L
E
NQ
YF
A
LD
M
HSD
A
A
KS
M
LE
S
G
SC
MIY
A
P
G
TMG
DL
K
P
E
L
F
A
V
fig|405955.9.peg.2592
Escherichia coli APEC O1 (4-442/445)
HRP
L
W
A
EG
T
F
LS
S
Q
Q
FQQQ
A
R
W
EA
FS
NDC
I
AQ
L
CIRHP
WG
I
A
N
VLF
D
R
DA
L
TP
GK
LKT
Q
A
V
R
L
RF
A
DGT
LID
S
D
VS
D
V
LP
L
A
-
CD
L
RA
L
K
N
DS
A
I-
VL
LALP
L
A
H
G
N
G
GNL
-
GQG
E
QT
E
R
PL
RY
--
R
QEWQK
V
Q
D
I
Y
GS
DS
E
DMA
V
E
RH
A
L
S
L
R
F
-
-
--
AHDN
NQ
D
YIT
C
PL
A
R
L
V-
R
D
V
Q
G
N
W
T
Q
D
E
S
Y
IP
PL
LA
FN
AH
DG
L
VQR
L
D
TLL
LQ
L
RA
KC
Q
R
L
M
A
MR
R
E
S
N
QRM
ADFAV
ADV
SL
F
WL
L
N
A
LN
S
A
E
PV
LSD
FL
R
YPA
V
HPE
LV
W
R
E
LA
R
L
A
G
A
L
L
TF
S
L
-
-
E
HNVS
A
V
P
-------
P
Y
V
H
E
S
P
ST
V
F
-
P
P
L
F
SLL
S
EL
L
E
AS
L
P
S
R
V
I
A
L
D
L
ASLP
G
N
R
W
---
K
A
D
L
HD
PR
L
RE
E
A
D
F
Y
L
S
V
RS
S
-
L
P
A
H
Q
V
L
H
Q
LPLVC
KI
G
A
P
DDV
TL
L
IN
V
A
L
N
G
V
Q
L
VP
L
T
S
V
P
AA
LP
L
R
L
E
NQ
YF
A
LD
M
HSD
A
A
KS
M
LE
S
G
SC
MIY
A
P
G
TMG
DL
K
P
E
L
F
A
V
fig|340197.3.peg.1249
Escherichia coli F11 (4-442/445)
HRP
L
W
A
EG
T
F
LS
S
Q
Q
FQQQ
A
R
W
EA
FS
NDC
I
AQ
L
CIRHP
WG
I
A
N
VLF
D
R
DA
L
TP
GK
LKT
Q
A
V
R
L
RF
A
DGT
LID
S
D
VS
D
V
LP
L
A
-
CD
L
RA
L
K
N
DS
A
I-
VL
LALP
L
A
H
G
N
G
GNL
-
GQG
E
QT
E
R
PL
RY
--
R
QEWQK
V
Q
D
I
Y
GS
DS
E
DMA
V
E
RH
A
L
S
L
R
F
-
-
--
AHDN
NQ
D
YIT
C
PL
A
R
L
V-
R
D
V
Q
G
N
W
T
Q
D
E
S
Y
IP
PL
LA
FN
AH
DG
L
VQR
L
D
TLL
LQ
L
RA
KC
Q
R
L
M
A
MR
R
E
S
N
QRM
ADFAV
ADV
SL
F
WL
L
N
A
LN
S
A
E
PV
LSD
FL
R
YPA
V
HPE
LV
W
R
E
LA
R
L
A
G
A
L
L
TF
S
L
-
-
E
HNVS
A
V
P
-------
P
Y
V
H
E
S
P
ST
V
F
-
P
P
L
F
SLL
S
EL
L
E
AS
L
P
S
R
V
I
A
L
D
L
ASLP
G
N
R
W
---
K
A
D
L
HD
PR
L
RE
E
A
D
F
Y
L
S
V
RS
S
-
L
P
A
H
Q
V
L
H
Q
LPLVC
KI
G
A
P
DDV
TL
L
IN
V
A
L
N
G
V
Q
L
VP
L
T
S
V
P
AA
LP
L
R
L
E
NQ
YF
A
LD
M
HSD
A
A
KS
M
LE
S
G
SC
MIY
A
P
G
TMG
DL
K
P
E
L
F
A
V
fig|340197.5.peg.1314
Escherichia coli F11 (4-442/445)
HRP
L
W
A
EG
T
F
LS
S
Q
Q
FQQQ
A
R
W
EA
FS
NDC
I
AQ
L
CIRHP
WG
I
A
N
VLF
D
R
DA
L
TP
GK
LKT
Q
A
V
R
L
RF
A
DGT
LID
S
D
VS
D
V
LP
L
A
-
CD
L
RA
L
K
N
DS
A
I-
VL
LALP
L
A
H
G
N
G
GNL
-
GQG
E
QT
E
R
PL
RY
--
R
QEWQK
V
Q
D
I
Y
GS
DS
E
DMA
V
E
RH
A
L
S
L
R
F
-
-
--
AHDN
NQ
D
YIT
C
PL
A
R
L
V-
R
D
V
Q
G
N
W
T
Q
D
E
S
Y
IP
PL
LA
FN
AH
DG
L
VQR
L
D
TLL
LQ
L
RA
KC
Q
R
L
M
A
MR
R
E
S
N
QRM
ADFAV
ADV
SL
F
WL
L
N
A
LN
S
A
E
PV
LSD
FL
R
YPA
V
HPE
LV
W
R
E
LA
R
L
A
G
A
L
L
TF
S
L
-
-
E
HNVS
A
V
P
-------
P
Y
V
H
E
S
P
ST
V
F
-
P
P
L
F
SLL
S
EL
L
E
AS
L
P
S
R
V
I
A
L
D
L
ASLP
G
N
R
W
---
K
A
D
L
HD
PR
L
RE
E
A
D
F
Y
L
S
V
RS
S
-
L
P
A
H
Q
V
L
H
Q
LPLVC
KI
G
A
P
DDV
TL
L
IN
V
A
L
N
G
V
Q
L
VP
L
T
S
V
P
AA
LP
L
R
L
E
NQ
YF
A
LD
M
HSD
A
A
KS
M
LE
S
G
SC
MIY
A
P
G
TMG
DL
K
P
E
L
F
A
V
fig|749550.3.peg.782
Escherichia coli MS 200-1 (4-442/445)
HRP
L
W
A
EG
T
F
LS
S
Q
Q
FQQQ
A
R
W
EA
FS
NDC
I
AQ
L
CIRHP
WG
I
A
N
VLF
D
R
DA
L
TP
GK
LKT
Q
A
V
R
L
RF
A
DGT
LID
S
D
VS
D
V
LP
L
A
-
CD
L
RA
L
K
N
DS
A
I-
VL
LALP
L
A
H
G
N
G
GNL
-
GQG
E
QT
E
R
PL
RY
--
R
QEWQK
V
Q
D
I
Y
GS
DS
E
DMA
V
E
RH
A
L
S
L
R
F
-
-
--
AHDN
NQ
D
YIT
C
PL
A
R
L
V-
R
D
V
Q
G
N
W
T
Q
D
E
S
Y
IP
PL
LA
FN
AH
DG
L
VQR
L
D
TLL
LQ
L
RA
KC
Q
R
L
M
A
MR
R
E
S
N
QRM
ADFAV
ADV
SL
F
WL
L
N
A
LN
S
A
E
PV
LSD
FL
R
YPA
V
HPE
LV
W
R
E
LA
R
L
A
G
A
L
L
TF
S
L
-
-
E
HNVS
A
V
P
-------
P
Y
V
H
E
S
P
ST
V
F
-
P
P
L
F
SLL
S
EL
L
E
AS
L
P
S
R
V
I
A
L
D
L
ASLP
G
N
R
W
---
K
A
D
L
HD
PR
L
RE
E
A
D
F
Y
L
S
V
RS
S
-
L
P
A
H
Q
V
L
H
Q
LPLVC
KI
G
A
P
DDV
TL
L
IN
V
A
L
N
G
V
Q
L
VP
L
T
S
V
P
AA
LP
L
R
L
E
NQ
YF
A
LD
M
HSD
A
A
KS
M
LE
S
G
SC
MIY
A
P
G
TMG
DL
K
P
E
L
F
A
V
fig|869729.3.peg.533
Escherichia coli UM146 (4-442/445)
HRP
L
W
A
EG
T
F
LS
S
Q
Q
FQQQ
A
R
W
EA
FS
NDC
I
AQ
L
CIRHP
WG
I
A
N
VLF
D
R
DA
L
TP
GK
LKT
Q
A
V
R
L
RF
A
DGT
LID
S
D
VS
D
V
LP
L
A
-
CD
L
RA
L
K
N
DS
A
I-
VL
LALP
L
A
H
G
N
G
GNL
-
GQG
E
QT
E
R
PL
RY
--
R
QEWQK
V
Q
D
I
Y
GS
DS
E
DMA
V
E
RH
A
L
S
L
R
F
-
-
--
AHDN
NQ
D
YIT
C
PL
A
R
L
V-
R
D
V
Q
G
N
W
T
Q
D
E
S
Y
IP
PL
LA
FN
AH
DG
L
VQR
L
D
TLL
LQ
L
RA
KC
Q
R
L
M
A
MR
R
E
S
N
QRM
ADFAV
ADV
SL
F
WL
L
N
A
LN
S
A
E
PV
LSD
FL
R
YPA
V
HPE
LV
W
R
E
LA
R
L
A
G
A
L
L
TF
S
L
-
-
E
HNVS
A
V
P
-------
P
Y
V
H
E
S
P
ST
V
F
-
P
P
L
F
SLL
S
EL
L
E
AS
L
P
S
R
V
I
A
L
D
L
ASLP
G
N
R
W
---
K
A
D
L
HD
PR
L
RE
E
A
D
F
Y
L
S
V
RS
S
-
L
P
A
H
Q
V
L
H
Q
LPLVC
KI
G
A
P
DDV
TL
L
IN
V
A
L
N
G
V
Q
L
VP
L
T
S
V
P
AA
LP
L
R
L
E
NQ
YF
A
LD
M
HSD
A
A
KS
M
LE
S
G
SC
MIY
A
P
G
TMG
DL
K
P
E
L
F
A
V
fig|656444.3.peg.1110
Escherichia coli TA280 (1-454/470)
M
HNE
Q
K
QI
Y
W
Y
S
G
L
Y
LQ
PQHFQ
SIDL
H
HS
Y
M
LAQ
H
LT
K
AQPWN
F
G
Y
Y
E
CEI
D
H
N
A
L
NE
SI
LK
ID
K
L
K
A
IL
P
S
G
YYLE
Y
P
GN
C
S
I
S
Q
KN
LF
D
SK
I
I
N
GH
P
IR
F
WI
AL
RR
F
D
P
K
F
P
N
V
-
SDN
N
EK
IS
NT
R
W
VST
VEEQL
M
RD
V
Y
-H
N
S
P
ETG
I
T
R
I
S
Y
N
I
Q
I
I
T
DEEK
D
H
ML
D
SEL
LP
I
T
R
L
I-
-
H
N
S
NG
LT
I
D
P
T
F
T
P
PF
L
S
VS
Q
S
DG
L
RSI
I
N
DI
Y
AS
L
CT
C
A
H
K
L
E
E
CKHT
E
L
NAS
S
FRKSG
NI
VRL
L
ML
C
M
F
NR
V
L
PI
MES
WQ
S
EKL
V
HP
W
YY
F
N
L
L
C
Q
L
I
GEL
S
S
F
D
K
T
S
S
S
L
T
S
N
K
N
HHCIVK
-
-
Y
D
H
Y
N
L
FE
C
F
-
S
SI
K
DH
I
S
N
L
L
I
K
L
S
L
DDN
I
A
I
P
L
QRVT
S
G
I
F
---
V
G
H
I
K
D
DS
NST
K
-
D
V
Y
L
M
L
R
A
E
NFR
N
N
SRV
F
I
HTPDI
KI
S
S
S
DD
I
NT
L
I
QH
A
L
PG
V
A
M
EL
I
E
C
AP
SG
LP
E
R
I
D
TV
W
L
KIN
T
DDI
L
W
DK
I
QR
EK
NI
AL
Y
W
VA
A
PE
DL
Y
V
E
L
fig|358709.5.peg.2634
Escherichia coli 101-1 (9-462/478)
M
YNE
Q
K
QI
Y
W
Y
S
G
L
Y
LQ
PQHFQ
SIDL
H
HS
Y
M
LAQ
H
IA
R
AQPWN
F
G
C
Y
E
CEI
D
H
G
A
L
NE
SI
LK
I
N
K
L
K
A
IL
P
S
G
YYLE
Y
P
GN
C
T
I
S
Q
KH
LV
D
SN
I
T
N
GH
P
IR
F
WI
AL
RR
F
D
P
K
Y
P
N
V
-
SDN
K
EK
TS
NT
R
W
IST
DEEQL
MK
D
V
Y
-H
N
S
P
ETG
I
T
R
I
S
Y
N
L
Q
I
I
S
DEEKNH
ML
D
SEL
LP
I
T
R
L
I-
-
H
E
N
NG
LT
V
D
P
T
FIP
PF
L
S
VF
Q
S
DG
L
RSI
I
D
DI
Y
YS
L
CA
C
A
H
K
L
E
A
CKHT
E
L
NAI
S
FRKNG
NI
VRL
L
ML
C
I
F
NR
V
L
PI
IES
WQ
R
EKL
V
HP
W
YY
F
N
L
L
C
Q
L
N
GEL
S
S
F
D
K
T
P
S
S
L
I
S
D
K
K
QHCIIK
-
-
Y
D
H
Y
N
L
FA
C
F
-
S
SI
K
DH
I
S
N
L
L
I
K
L
S
L
DDN
I
E
I
P
L
RRVT
S
G
I
F
---
V
G
N
I
I
E
NS
T
L
S
N
-
D
V
Y
I
M
L
RS
E
VFR
G
N
AKA
L
I
HTPDI
KI
S
S
S
DD
I
NT
I
I
QH
A
L
PG
V
A
V
EL
M
E
C
AP
GG
LP
E
R
M
D
TV
W
L
KIN
V
ADV
L
W
SK
I
QR
DK
NI
S
L
Y
W
VA
A
PE
DL
Y
I
E
L
fig|550672.3.peg.534
Escherichia coli B088 (1-445/454)
M
QEEEQL
V
Y
W
Y
S
G
L
Y
LQ
PQHFQ
SIDL
H
HS
F
M
LAR
T
RQ
L
SQPHH
Q
G
Y
Y
E
CRI
N
D
D
LL
KE
DT
V
R
I
E
K
I
K
A
VL
SS
G
YY
I
E
Y
P
GN
C
V
V
Q
D
KC
LT
N
LR
G
T
D
PG
T
VN
LW
LAL
KR
F
N
S
S
H
K
N
V
-
SSV
N
DK
R
G
SV
R
W
VC
S
EDESN
M
R
N
V
Y
-H
DS
Q
DAG
I
T
R
I
K
Y
D
I
Q
I
V
T
DEEK
E
N
ST
D
F
EY
LPL
T
R
V
I-
-
Y
G
N
NI
L
C
I
DD
E
CSF
PA
MR
LS
A
N
HK
L
RDK
I
I
E
I
H
SD
I
NA
YK
N
K
L
E
E
Y
R
YT
E
R
TVS
--
--
DGH
L
YN
F
LI
L
C
A
I
NR
T
L
PL
LS
S
FI
N
EDA
I
HP
W
LY
Y
M
A
L
C
Q
FT
GE
I
S
TF
Q
-
-
-
N
F
V
F
S
D
T
R
---
IIDL
S
Y
N
H
Y
D
Q
IS
C
F
-
S
H
L
Q
YY
I
K
AV
L
E
N
L
C
R
D
K
I
I
SV
E
F
KKIT
T
D
T
F
---
I
C
D
FD
E
YS
S
R
N
N
S
E
Y
Y
I
K
L
T
S
D
TFK
K
N
N--
S
I
A
L
S
E
I
KI
A
PS
E
H
I
DL
I
I
QH
A
L
PGI
N
F
TV
M
D
V
V
TS
E
L
Q
V
R
E
N
II
LL
KI
DK
HSE
L
W
KL
D
KA
QK
RV
A
F
Y
W
S
C
S
PD
DL
L
V
E
L
fig|1040638.4.peg.2407
Escherichia coli O104:H4 str. LB226692 (1-445/470)
M
QEEEQL
V
Y
W
Y
S
G
L
Y
LQ
PQHFQ
SIDL
H
HG
F
M
LAR
S
RQ
L
SQPHH
Q
G
Y
Y
E
CCI
N
D
D
LL
KE
DT
V
R
VE
K
I
K
A
VL
SS
G
YY
I
E
Y
P
GN
C
V
V
Q
D
KC
LT
N
LK
G
S
D
HG
T
VD
LW
LAL
KR
F
N
S
G
H
K
N
V
-
SSV
N
DK
R
G
SA
R
W
IS
S
DDERN
M
R
N
V
Y
-H
DS
Q
DAD
I
T
R
I
K
Y
D
I
Q
I
L
T
DEEK
DN
TT
D
Y
EY
LPL
T
RI
I-
-
Y
G
N
N
SL
C
I
DD
E
CSF
PV
MR
LS
A
N
HK
L
RNK
I
A
E
I
Y
SD
I
KF
YK
N
R
L
E
K
Y
R
YT
E
R
TVS
--
--
DGH
L
YN
F
LI
L
C
A
I
NR
T
L
PL
LS
S
FI
N
EDA
I
HP
W
LY
Y
M
A
L
C
Q
F
A
GE
I
S
TF
H
-
-
-
N
SGL
S
D
T
R
---
IVEL
S
Y
N
H
Y
E
Q
IS
C
F
-
S
D
L
Q
YY
I
K
LI
L
D
D
S
C
R
D
K
I
I
SV
E
F
RKIT
T
D
TL
---
I
C
N
FD
E
YG
AGS
N
S
D
Y
Y
I
K
L
T
S
D
TFR
K
N
K
--
L
I
A
L
P
E
I
KI
A
PS
E
H
I
DM
I
I
QH
A
L
PGI
K
F
TV
M
D
A
V
TSD
L
Q
V
R
E
N
TI
W
L
KI
DK
HSE
L
W
TL
A
QT
QK
RV
A
F
Y
W
S
C
S
PD
DL
L
V
E
L
fig|6666666.5357.peg.1843
Escherichia coli TY-2482 (1-445/470)
M
QEEEQL
V
Y
W
Y
S
G
L
Y
LQ
PQHFQ
SIDL
H
HG
F
M
LAR
S
RQ
L
SQPHH
Q
G
Y
Y
E
CCI
N
D
D
LL
KE
DT
V
R
VE
K
I
K
A
VL
SS
G
YY
I
E
Y
P
GN
C
V
V
Q
D
KC
LT
N
LK
G
S
D
HG
T
VD
LW
LAL
KR
F
N
S
G
H
K
N
V
-
SSV
N
DK
R
G
SA
R
W
IS
S
DDERN
M
R
N
V
Y
-H
DS
Q
DAD
I
T
R
I
K
Y
D
I
Q
I
L
T
DEEK
DN
TT
D
Y
EY
LPL
T
RI
I-
-
Y
G
N
N
SL
C
I
DD
E
CSF
PV
MR
LS
A
N
HK
L
RNK
I
A
E
I
Y
SD
I
KF
YK
N
R
L
E
K
Y
R
YT
E
R
TVS
--
--
DGH
L
YN
F
LI
L
C
A
I
NR
T
L
PL
LS
S
FI
N
EDA
I
HP
W
LY
Y
M
A
L
C
Q
F
A
GE
I
S
TF
H
-
-
-
N
SGL
S
D
T
R
---
IVEL
S
Y
N
H
Y
E
Q
IS
C
F
-
S
D
L
Q
YY
I
K
LI
L
D
D
S
C
R
D
K
I
I
SV
E
F
RKIT
T
D
TL
---
I
C
N
FD
E
YG
AGS
N
S
D
Y
Y
I
K
L
T
S
D
TFR
K
N
K
--
L
I
A
L
P
E
I
KI
A
PS
E
H
I
DM
I
I
QH
A
L
PGI
K
F
TV
M
D
A
V
TSD
L
Q
V
R
E
N
TI
W
L
KI
DK
HSE
L
W
TL
A
QT
QK
RV
A
F
Y
W
S
C
S
PD
DL
L
V
E
L
fig|216592.1.peg.2525
Escherichia coli 042 (7-451/476)
M
QEEEQL
V
Y
W
Y
S
G
L
Y
LQ
PQHFQ
SIDL
H
HG
F
M
LAR
S
RQ
L
SQPHH
Q
G
Y
Y
E
CCI
N
D
D
LL
KE
DT
V
R
VE
K
I
K
A
VL
SS
G
YY
I
E
Y
P
GN
C
V
V
Q
D
KC
LT
N
LK
G
S
D
HG
T
VD
LW
LAL
KR
F
N
S
G
H
K
N
V
-
SSV
N
DK
R
G
SA
R
W
IS
S
DDERN
M
R
N
V
Y
-H
DS
Q
DAD
I
T
R
I
K
Y
D
I
Q
I
L
T
DEEK
DN
TT
D
Y
EY
LPL
T
RI
I-
-
Y
G
N
N
SL
C
I
DD
E
CSF
PV
MR
LS
A
N
HK
L
RNK
I
A
E
I
Y
SD
I
KF
YK
N
R
L
E
K
Y
R
YT
E
R
TVS
--
--
DGH
L
YN
F
LI
L
C
A
I
NR
T
L
PL
LS
S
FI
N
EDA
I
HP
W
LY
Y
M
A
L
C
Q
F
A
GE
I
S
TF
H
-
-
-
N
SGL
S
D
T
R
---
IVEL
S
Y
N
H
Y
E
Q
IS
C
F
-
S
D
L
Q
YY
I
K
LI
L
D
D
S
C
R
D
K
I
I
SV
E
F
RKIT
T
D
TL
---
I
C
N
FD
E
YG
AGS
N
S
D
Y
Y
I
K
L
T
S
D
TFR
K
N
K
--
L
I
A
L
P
E
I
KI
A
PS
E
H
I
DM
I
I
QH
A
L
PGI
K
F
TV
M
D
A
V
TSD
L
Q
V
R
E
N
TI
W
L
KI
DK
HSE
L
W
TL
A
QT
QK
RV
A
F
Y
W
S
C
S
PD
DL
L
V
E
L
fig|216592.3.peg.4748
Escherichia coli 042 (1-445/470)
M
QEEEQL
V
Y
W
Y
S
G
L
Y
LQ
PQHFQ
SIDL
H
HG
F
M
LAR
S
RQ
L
SQPHH
Q
G
Y
Y
E
CCI
N
D
D
LL
KE
DT
V
R
VE
K
I
K
A
VL
SS
G
YY
I
E
Y
P
GN
C
V
V
Q
D
KC
LT
N
LK
G
S
D
HG
T
VD
LW
LAL
KR
F
N
S
G
H
K
N
V
-
SSV
N
DK
R
G
SA
R
W
IS
S
DDERN
M
R
N
V
Y
-H
DS
Q
DAD
I
T
R
I
K
Y
D
I
Q
I
L
T
DEEK
DN
TT
D
Y
EY
LPL
T
RI
I-
-
Y
G
N
N
SL
C
I
DD
E
CSF
PV
MR
LS
A
N
HK
L
RNK
I
A
E
I
Y
SD
I
KF
YK
N
R
L
E
K
Y
R
YT
E
R
TVS
--
--
DGH
L
YN
F
LI
L
C
A
I
NR
T
L
PL
LS
S
FI
N
EDA
I
HP
W
LY
Y
M
A
L
C
Q
F
A
GE
I
S
TF
H
-
-
-
N
SGL
S
D
T
R
---
IVEL
S
Y
N
H
Y
E
Q
IS
C
F
-
S
D
L
Q
YY
I
K
LI
L
D
D
S
C
R
D
K
I
I
SV
E
F
RKIT
T
D
TL
---
I
C
N
FD
E
YG
AGS
N
S
D
Y
Y
I
K
L
T
S
D
TFR
K
N
K
--
L
I
A
L
P
E
I
KI
A
PS
E
H
I
DM
I
I
QH
A
L
PGI
K
F
TV
M
D
A
V
TSD
L
Q
V
R
E
N
TI
W
L
KI
DK
HSE
L
W
TL
A
QT
QK
RV
A
F
Y
W
S
C
S
PD
DL
L
V
E
L
fig|585055.6.peg.3325
Escherichia coli 55989 (1-445/470)
M
QEEEQL
V
Y
W
Y
S
G
L
Y
LQ
PQHFQ
SIDL
H
HG
F
M
LAR
S
RQ
L
SQPHH
Q
G
Y
Y
E
CCI
N
D
D
LL
KE
DT
V
R
VE
K
I
K
A
VL
SS
G
YY
I
E
Y
P
GN
C
V
V
Q
D
KC
LT
N
LK
G
S
D
HG
T
VD
LW
LAL
KR
F
N
S
G
H
K
N
V
-
SSV
N
DK
R
G
SA
R
W
IS
S
DDERN
M
R
N
V
Y
-H
DS
Q
DAD
I
T
R
I
K
Y
D
I
Q
I
L
T
DEEK
DN
TT
D
Y
EY
LPL
T
RI
I-
-
Y
G
N
N
SL
C
I
DD
E
CSF
PV
MR
LS
A
N
HK
L
RNK
I
A
E
I
Y
SD
I
KF
YK
N
R
L
E
K
Y
R
YT
E
R
TVS
--
--
DGH
L
YN
F
LI
L
C
A
I
NR
T
L
PL
LS
S
FI
N
EDA
I
HP
W
LY
Y
M
A
L
C
Q
F
A
GE
I
S
TF
H
-
-
-
N
SGL
S
D
T
R
---
IVEL
S
Y
N
H
Y
E
Q
IS
C
F
-
S
D
L
Q
YY
I
K
LI
L
D
D
S
C
R
D
K
I
I
SV
E
F
RKIT
T
D
TL
---
I
C
N
FD
E
YG
AGS
N
S
D
Y
Y
I
K
L
T
S
D
TFR
K
N
K
--
L
I
A
L
P
E
I
KI
A
PS
E
H
I
DM
I
I
QH
A
L
PGI
K
F
TV
M
D
A
V
TSD
L
Q
V
R
E
N
TI
W
L
KI
DK
HSE
L
W
TL
A
QT
QK
RV
A
F
Y
W
S
C
S
PD
DL
L
V
E
L
fig|585055.8.peg.3329
Escherichia coli 55989 (1-445/470)
M
QEEEQL
V
Y
W
Y
S
G
L
Y
LQ
PQHFQ
SIDL
H
HG
F
M
LAR
S
RQ
L
SQPHH
Q
G
Y
Y
E
CCI
N
D
D
LL
KE
DT
V
R
VE
K
I
K
A
VL
SS
G
YY
I
E
Y
P
GN
C
V
V
Q
D
KC
LT
N
LK
G
S
D
HG
T
VD
LW
LAL
KR
F
N
S
G
H
K
N
V
-
SSV
N
DK
R
G
SA
R
W
IS
S
DDERN
M
R
N
V
Y
-H
DS
Q
DAD
I
T
R
I
K
Y
D
I
Q
I
L
T
DEEK
DN
TT
D
Y
EY
LPL
T
RI
I-
-
Y
G
N
N
SL
C
I
DD
E
CSF
PV
MR
LS
A
N
HK
L
RNK
I
A
E
I
Y
SD
I
KF
YK
N
R
L
E
K
Y
R
YT
E
R
TVS
--
--
DGH
L
YN
F
LI
L
C
A
I
NR
T
L
PL
LS
S
FI
N
EDA
I
HP
W
LY
Y
M
A
L
C
Q
F
A
GE
I
S
TF
H
-
-
-
N
SGL
S
D
T
R
---
IVEL
S
Y
N
H
Y
E
Q
IS
C
F
-
S
D
L
Q
YY
I
K
LI
L
D
D
S
C
R
D
K
I
I
SV
E
F
RKIT
T
D
TL
---
I
C
N
FD
E
YG
AGS
N
S
D
Y
Y
I
K
L
T
S
D
TFR
K
N
K
--
L
I
A
L
P
E
I
KI
A
PS
E
H
I
DM
I
I
QH
A
L
PGI
K
F
TV
M
D
A
V
TSD
L
Q
V
R
E
N
TI
W
L
KI
DK
HSE
L
W
TL
A
QT
QK
RV
A
F
Y
W
S
C
S
PD
DL
L
V
E
L
Consen1
Primary consensus
MATtrnkvmW
EG
l
pqhFQQQqRy
yl
r
a
WGf
e
n
elL
GKimid
a
g
pDGTvfs
p
D
LP
p
-
p
f
d
s
iyLALPv
s
v
nei
-
s
rr
Ry
--
r
VrD
h
egd
l
lg
L
pRi
s
--
gaed
ayiTlPL
Ri
rha
Gslt
Dd
fIP
qn
vs
L
l
evq
i
ra
dLa
--
Ri
s
sg
--
iADVaeFmmLq
LNr
q
fth
r
lHPE
y
dLa
LlGeLmTF
e
-
rlpc
l
-------
Y
H
dl
tF
-
tl
pev
raL
tvL
pRa
nl
L
G
-
W
---
A
ihD
Llq
a
fvLaVaa
-
mP
dqiq
qfiqqsKi
speki
mvsVqipGi
L
Lm
aPrqLP
h
g
YFeLdk
Aw
m
aG
alh
sGsfpDLn
qLwAiRG
Consen2
Secondary consensus
mkhrp
f
shq
a
fs
i
l
i
n
d
da
lkt
v
l
a
lid
d
a
l
l
vl
l
n
gnlq
e
g
w
s
q
y
ds
v
rh
l
f
-
ahdn
dmv
c
l
k
v
wv
y
la
ah
s
tll
l
kc
r
m
mr
e
n
adfav
sl
wl
n
s
e
lsd
v
w
e
v
a
a
l
l
hnvs
v
p
v
t
pv
sll
el
as
s
v
i
r
re
c
ly
s
rs
hk
l
ilplvc
v
atddv
in
a
n
v
t
v
aa
r
e
a
em
a
v
s
miy
p
tmg
k
e
f
v
Consensus 1
(when a gap)
Conservative difference
Consensus 2
(when a gap)
Nonconservative diff.
Other character