┌─ Escherichia coli (16-335/336) MS 21-1   
                                                 ┌┴─ Escherichia coli (16-335/336) B354   
                                                ┌┴─ fig|1040638.4.peg.4223 O104:H4 (16-335/336) str. LB226692 (62)  
                                               ┌┴─ Escherichia coli (16-335/336) EC4100B   
                                              ┌┤ ┌─ Escherichia coli (26-345/346) O157:H7 (2)  
                                              │└┬┴─ Escherichia coli (16-335/336) E110019 (1)  
                                             ┌┤ └┬─ Escherichia coli (16-335/336) MS 124-1 (1)  
                                             ││  └─ Escherichia coli (26-345/346) E22 (1)  
                                             │└┬─ Escherichia coli (26-345/346) APEC O1 (22)  
        ┌────────────────────────────────────┤ └┬─ Escherichia coli (16-335/336) M605 (1)  
        │                                    │  └─ Escherichia coli (16-335/336) 2362-75 (2)  
┌───────┤                                    └─ Escherichia coli (26-345/346) 53638 (1)  
│       │                                                          ┌─ Escherichia coli (1-360/369) CFT073  [2] 
│       └──────────────────────────────────────────────────────────┤┌─ Escherichia coli (1-360/369) 2362-75 (26)  
│                                                                  ││   ┌─ Escherichia coli (1-360/369) K12 (7)  
│                                                                  └┤  ┌┴─ Escherichia coli (1-360/369) 101-1   
│                                                                   │ ┌┴─ Escherichia coli (1-360/369) 1827-70 (10)  
│                                                                   │┌┴─ Escherichia coli (1-360/369) MS 21-1   
│                                                                   └┤┌─ Escherichia coli (1-360/369) SMS-3-5   
│                                                                    └┤ ┌─ fig|6666666.5357.peg.2255 TY-2482 (1-359/368) strain   
│                                                                     └┬┴─ Escherichia coli (1-360/369) B088   
│                                                                      └┬─ Escherichia coli (1-360/369) MS 69-1   
│                                                                       └─ fig|1040638.4.peg.5373 O104:H4 (1-360/369) str. LB226692 (76)  
│                                                            ┌─ Escherichia coli B185   
│                                                           ┌┴─ Escherichia coli M718   
│                                                          ┌┴┬─ Escherichia coli DH1   
│                                                         ┌┤ └─ Escherichia coli MS 115-1   
│                                                        ┌┤└─ Escherichia coli K12 (25)  
│                                                       ┌┤└─ Escherichia coli HS (1)  
│                                                       │└┬─ Escherichia coli 1044A (25)  
│                                                      ┌┤ └─ Escherichia coli MS 78-1   
│                                                      │└┬─ Escherichia coli B088 (14)  
┤                                                      │ └┬─ fig|1040638.4.peg.5480 O104:H4 str. LB226692 (3)  
│                                                     ┌┤  └┬─ Escherichia coli E110019 (1)  
│                                                     ││   └┬─ Escherichia coli O26:H11 str. 11368   
│                                                     ││    └─ Escherichia coli O111:H- str. 11128   
│                                                     │└┬─ Escherichia coli SMS-3-5   
│                                                    ┌┤ └┬─ Escherichia coli (1-332/349) MS 21-1   
│                                                    ││  └─ Escherichia coli 042 (1)  
│                                                    ││┌─ Escherichia coli H299   
│                                                    │└┤┌─ Escherichia coli TA280   
│                                                    │ └┤ ┌─ Escherichia coli B354   
│                                                    │  │┌┴─ Escherichia coli MS 69-1   
│                                                    │  └┤┌─ Escherichia coli TA143   
│                                                    │   └┤┌─ Escherichia coli O83:H1 str. NRG 857C   
│                                                   ┌┤    └┤┌─ Escherichia coli NC101   
│                                                   ││     └┤  ┌─ Escherichia coli TA206   
│                                                   ││      │ ┌┴─ Escherichia coli 83972 (5)  
│                                                   ││      └┬┴─ Escherichia coli APEC O1 (6)  
│                                                   ││       └┬─ Escherichia coli M605 (1)  
│                   ┌───────────────────────────────┤│        └┬─ Escherichia coli 536 (4)  
│                   │                               ││         └┬─ Escherichia coli 2362-75 (1)  
│                   │                               ││          └─ Escherichia coli E2348/69 (1)  
│                   │                               │└─ Escherichia coli FVEC1302 (3)  
└───────────────────┤                               └─ Escherichia coli ED1a (1)  
                    │                                         ┌─ Escherichia coli (18-349/353) MS 145-7   
                    │                                         │ ┌─ Escherichia coli (4-335/339) K12 (18)  
                    │                                         │┌┴─ Escherichia coli (4-335/339) IAI39 (1)  
                    └─────────────────────────────────────────┤│ ┌─ Escherichia coli (4-335/339) 53638 (4)  
                                                              ││┌┴─ Escherichia coli (4-335/339) ED1a (2)  
                                                              │││      ┌─ Escherichia coli (4-335/339) TA280   
                                                              └┤│     ┌┴─ Escherichia coli (4-335/339) B354   
                                                               ││    ┌┴─ Escherichia coli (4-335/339) E22 (3)  
                                                               ││   ┌┴─ Escherichia coli (14-349/353) E22   
                                                               ││  ┌┴┬─ Escherichia coli (4-335/339) O111:H- str. 11128   
                                                               ││  │ └┬─ Escherichia coli (4-335/339) M718   
                                                               └┤ ┌┤  └┬─ Escherichia coli (14-349/353) 042 (1) [2] 
                                                                │ ││   └─ Escherichia coli (4-335/339) H736   
                                                                │ │└┬─ Escherichia coli (4-335/339) MS 107-1   
                                                                │┌┤ └─ Escherichia coli (14-349/353) MS 182-1   
                                                                │││  ┌─ Escherichia coli (4-335/339) 101-1 (5)  
                                                                │││ ┌┴─ Escherichia coli (14-349/353) E24377A  [2] 
                                                                ││└┬┴─ Escherichia coli (14-349/353) E110019   
                                                                ││ └┬─ Escherichia coli (14-349/353) B171   
                                                                └┤  └┬─ Escherichia coli (4-335/339) B171   
                                                                 │   └┬─ Escherichia coli (4-335/339) MS 187-1   
                                                                 │    └─ Escherichia coli (4-335/339) MS 78-1 (1)  
                                                                 │┌─ Escherichia coli (14-349/353) 53638 (2)  
                                                                 ││ ┌─ Escherichia coli (14-349/353) HS   
                                                                 ││┌┴─ Escherichia coli (4-335/339) EC4100B (4)  
                                                                 └┤│     ┌─ Escherichia coli (14-349/353) ABU 83972 (2)  
                                                                  ││    ┌┴─ Escherichia coli (4-335/339) 83972   
                                                                  ││   ┌┴─ Escherichia coli (14-349/353) CFT073  [2] 
                                                                  ││  ┌┴─ Escherichia coli (14-349/353) E2348/69   
                                                                  └┤ ┌┴─ Escherichia coli (4-335/339) H299 (1)  
                                                                   │┌┴┬─ Escherichia coli (14-349/353) O157:H7 EDL933   
                                                                   ││ └┬─ Escherichia coli (4-335/339) O55:H7 str. CB9615   
                                                                   ││  └─ Escherichia coli (4-335/339) 1044A (22)  
                                                                   ││    ┌─ Escherichia coli (4-335/339) MS 69-1   
                                                                   └┤   ┌┴─ Escherichia coli (4-335/339) TA143   
                                                                    │  ┌┴─ Escherichia coli (4-335/339) 536 (3)  
                                                                    │ ┌┴─ Escherichia coli (14-349/353) F11   
                                                                    │┌┴─ Escherichia coli (14-349/353) APEC O1 (1) [2] 
                                                                    └┤  ┌─ Escherichia coli (14-349/353) MS 124-1   
                                                                     │ ┌┴─ Escherichia coli (4-335/339) MS 84-1   
                                                                     └┬┴─ fig|1040638.4.peg.975 O104:H4 (14-349/353) str. LB226692 (1) [2] 
                                                                      └┬─ Escherichia coli (4-335/339) WV_060327   
                                                                       └┬─ Escherichia coli (4-335/339) SMS-3-5   
                                                                        └┬─ Escherichia coli (4-335/339) M605   
                                                                         └┬─ Escherichia coli (4-335/339) H591 (1)  
                                                                          └─ Escherichia coli (4-335/339) TA271   
  
Alcohol dehydrogenase (EC 1.1.1.1) (87)
S-(hydroxymethyl)glutathione dehydrogenase (EC 1.1.1.284) (9)
Others (5)