fig|562.376.peg.375
Escherichia coli WV_060327
MSVKIVIK
P
N
T
Y
F
DSVSLM
S
IS
T
R
A
N
KL
D
GV
E
QA
F
V
A
M
A
T
E
M
NK
GV
L
KNL
GL
LTPELG
Q
A
K
NG
DL
M
I
V
I
N
G
K
SGVD
NE
Q
L
LA
E
I
EE
L
FN
T
K
A
Q
----
SG
SH
E
A
R
YA
T
----
IA
SA
K
K
YI
PE
S
NLA
V
ISV
N
G
L
F
AA
R
EA
R
QAL
QND
LNVM
L
FSDNVS
V
EDE
LA
LK
Q
LA
H
EKGLL
M
MGPDCGTAIING
A
A
L
C
F
G
N
A
V
R
RGNIG
IV
GASGTG
S
QEL
SV
RI
HEF
G
G
G
V
SQ
L
IGTGGRDLSE
K
IGG
LM
ML
D
A
I
G
ML
EN
D
P
Q
TE
I
I
V
LISKPPAPAVARK
V
LERA
R
AC
R
KPVVA
C
FLG
RG
E
TSVDEQ
G
L
Q
FA
RGSK
EAA
LK
AV
M
L
---
SGVKQEHLDLHTLNQ
P
LIA
DV
RA
RL
QPQQKY
IRGLF
C
GGTLC
D
E
T
LF
A
V
MEKH
G
-D
V
Y
SN
IQP
D
PEFR
L
QD
I
NR
S
IK
HT
F
LD
F
GDDDFT
N
GKPHPMIDPT
N
R
I
S
RL
I
E
E
AR
DP
E
VAV
I
V
M
D
F
VLGFG
S
HE
DP
V
G
S
T
I
E
A
IR
E
A
K
A
I
A
AA
E
G
R
E
L
II
L
A
Y
V
L
GT
D
L
D
TP
S
LE
QQ
S
QM
L
L
DAGVI
L
ASS
STN
T
G
LLA
REF
ICKGEEA
fig|1040638.4.peg.5469
Escherichia coli O104:H4 str. LB226692
MSVKIVIK
P
N
T
Y
F
DSVSLM
S
IS
T
R
A
N
KL
D
GV
E
QA
F
V
A
M
A
T
E
M
NK
GV
L
KNL
GL
LTPELE
Q
A
K
NG
DL
M
I
V
I
N
G
K
AGAD
NE
Q
L
LV
E
I
EE
L
FN
S
K
A
Q
----
SG
SH
E
A
R
YA
T
----
IA
SA
K
K
HI
PE
S
NLA
V
ISV
N
G
L
F
AA
R
EA
R
QAL
QND
LNVM
L
FSDNVS
V
EDE
LA
LK
Q
LA
H
EKGLL
M
MGPDCGTAIING
A
A
L
C
F
G
N
A
V
R
RGNIG
IV
GASGTG
S
QEL
SV
RI
HEF
G
G
G
V
SQ
L
IGTGGRDLSE
K
IGG
LM
ML
D
A
I
G
ML
EN
D
P
Q
TE
I
IALISKPPAPAVARK
V
LERA
R
AC
R
KPVV
V
C
FLG
RV
E
TPVDEQ
G
L
Q
FA
RGSK
EAA
LK
AV
M
L
---
SGVKQENLDLHTLNQ
P
LIA
DV
RA
RL
QPQQKY
IRGLF
C
GGTLC
D
E
T
MF
A
V
MEKH
G
-D
V
Y
SN
IQP
D
PEFR
L
QD
I
NR
S
IK
HT
F
LD
F
GDDDFT
N
GKPHPMIDPT
N
R
I
S
RL
I
E
E
AR
DP
E
VAV
I
V
M
D
F
VLGFG
S
HE
DP
V
G
S
T
I
E
A
IK
E
A
K
A
I
A
AA
E
G
R
E
L
II
L
A
Y
V
L
GT
D
L
D
TP
S
LE
QQ
S
QM
L
L
DAGVI
L
ASS
STN
T
G
LLA
REF
ICKGEEA
fig|6666666.5357.peg.204
Escherichia coli TY-2482
MSVKIVIK
P
N
T
Y
F
DSVSLM
S
IS
T
R
A
N
KL
D
GV
E
QA
F
V
A
M
A
T
E
M
NK
GV
L
KNL
GL
LTPELE
Q
A
K
NG
DL
M
I
V
I
N
G
K
AGAD
NE
Q
L
LV
E
I
EE
L
FN
S
K
A
Q
----
SG
SH
E
A
R
YA
T
----
IA
SA
K
K
HI
PE
S
NLA
V
ISV
N
G
L
F
AA
R
EA
R
QAL
QND
LNVM
L
FSDNVS
V
EDE
LA
LK
Q
LA
H
EKGLL
M
MGPDCGTAIING
A
A
L
C
F
G
N
A
V
R
RGNIG
IV
GASGTG
S
QEL
SV
RI
HEF
G
G
G
V
SQ
L
IGTGGRDLSE
K
IGG
LM
ML
D
A
I
G
ML
EN
D
P
Q
TE
I
IALISKPPAPAVARK
V
LERA
R
AC
R
KPVV
V
C
FLG
RV
E
TPVDEQ
G
L
Q
FA
RGSK
EAA
LK
AV
M
L
---
SGVKQENLDLHTLNQ
P
LIA
DV
RA
RL
QPQQKY
IRGLF
C
GGTLC
D
E
T
MF
A
V
MEKH
G
-D
V
Y
SN
IQP
D
PEFR
L
QD
I
NR
S
IK
HT
F
LD
F
GDDDFT
N
GKPHPMIDPT
N
R
I
S
RL
I
E
E
AR
DP
E
VAV
I
V
M
D
F
VLGFG
S
HE
DP
V
G
S
T
I
E
A
IK
E
A
K
A
I
A
AA
E
G
R
E
L
II
L
A
Y
V
L
GT
D
L
D
TP
S
LE
QQ
S
QM
L
L
DAGVI
L
ASS
STN
T
G
LLA
REF
ICKGEEA
fig|585055.6.peg.329
Escherichia coli 55989
MSVKIVIK
P
N
T
Y
F
DSVSLM
S
IS
T
R
A
N
KL
D
GV
E
QA
F
V
A
M
A
T
E
M
NK
GV
L
KNL
GL
LTPELE
Q
A
K
NG
DL
M
I
V
I
N
G
K
AGAD
NE
Q
L
LV
E
I
EE
L
FN
S
K
A
Q
----
SG
SH
E
A
R
YA
T
----
IA
SA
K
K
HI
PE
S
NLA
V
ISV
N
G
L
F
AA
R
EA
R
QAL
QND
LNVM
L
FSDNVS
V
EDE
LA
LK
Q
LA
H
EKGLL
M
MGPDCGTAIING
A
A
L
C
F
G
N
A
V
R
RGNIG
IV
GASGTG
S
QEL
SV
RI
HEF
G
G
G
V
SQ
L
IGTGGRDLSE
K
IGG
LM
ML
D
A
I
G
ML
EN
D
P
Q
TE
I
IALISKPPAPAVARK
V
LERA
R
AC
R
KPVV
V
C
FLG
RV
E
TPVDEQ
G
L
Q
FA
RGSK
EAA
LK
AV
M
L
---
SGVKQENLDLHTLNQ
P
LIA
DV
RA
RL
QPQQKY
IRGLF
C
GGTLC
D
E
T
MF
A
V
MEKH
G
-D
V
Y
SN
IQP
D
PEFR
L
QD
I
NR
S
IK
HT
F
LD
F
GDDDFT
N
GKPHPMIDPT
N
R
I
S
RL
I
E
E
AR
DP
E
VAV
I
V
M
D
F
VLGFG
S
HE
DP
V
G
S
T
I
E
A
IK
E
A
K
A
I
A
AA
E
G
R
E
L
II
L
A
Y
V
L
GT
D
L
D
TP
S
LE
QQ
S
QM
L
L
DAGVI
L
ASS
STN
T
G
LLA
REF
ICKGEEA
fig|585055.8.peg.330
Escherichia coli 55989
MSVKIVIK
P
N
T
Y
F
DSVSLM
S
IS
T
R
A
N
KL
D
GV
E
QA
F
V
A
M
A
T
E
M
NK
GV
L
KNL
GL
LTPELE
Q
A
K
NG
DL
M
I
V
I
N
G
K
AGAD
NE
Q
L
LV
E
I
EE
L
FN
S
K
A
Q
----
SG
SH
E
A
R
YA
T
----
IA
SA
K
K
HI
PE
S
NLA
V
ISV
N
G
L
F
AA
R
EA
R
QAL
QND
LNVM
L
FSDNVS
V
EDE
LA
LK
Q
LA
H
EKGLL
M
MGPDCGTAIING
A
A
L
C
F
G
N
A
V
R
RGNIG
IV
GASGTG
S
QEL
SV
RI
HEF
G
G
G
V
SQ
L
IGTGGRDLSE
K
IGG
LM
ML
D
A
I
G
ML
EN
D
P
Q
TE
I
IALISKPPAPAVARK
V
LERA
R
AC
R
KPVV
V
C
FLG
RV
E
TPVDEQ
G
L
Q
FA
RGSK
EAA
LK
AV
M
L
---
SGVKQENLDLHTLNQ
P
LIA
DV
RA
RL
QPQQKY
IRGLF
C
GGTLC
D
E
T
MF
A
V
MEKH
G
-D
V
Y
SN
IQP
D
PEFR
L
QD
I
NR
S
IK
HT
F
LD
F
GDDDFT
N
GKPHPMIDPT
N
R
I
S
RL
I
E
E
AR
DP
E
VAV
I
V
M
D
F
VLGFG
S
HE
DP
V
G
S
T
I
E
A
IK
E
A
K
A
I
A
AA
E
G
R
E
L
II
L
A
Y
V
L
GT
D
L
D
TP
S
LE
QQ
S
QM
L
L
DAGVI
L
ASS
STN
T
G
LLA
REF
ICKGEEA
fig|562.375.peg.5158
Escherichia coli EC4100B
MSVKIVIK
P
N
T
Y
F
DSVSLM
S
IS
T
R
A
N
KL
D
GV
E
QA
F
V
A
M
A
T
E
M
NK
GV
L
KNL
GL
LTPELE
Q
A
K
NG
DL
M
I
V
I
N
G
K
AGAD
NE
Q
L
LV
E
I
EE
L
FN
S
K
A
Q
----
SG
SH
E
A
R
YA
T
----
IA
SA
K
K
HI
PE
S
NLA
V
ISV
N
G
L
F
AA
R
EA
R
QAL
QND
LNVM
L
FSDNVS
V
EDE
LA
LK
Q
LA
H
EKGLL
M
MGPDCGTAIING
A
A
L
C
F
G
N
A
V
R
RGNIG
IV
GASGTG
S
QEL
SV
RI
HEF
G
G
G
V
SQ
L
IGTGGRDLSE
K
IGG
LM
ML
D
A
I
G
ML
EN
D
P
Q
TE
I
IALISKPPAPAVARK
V
LERA
R
AC
R
KPVV
V
C
FLG
RV
E
TPVDEQ
G
L
Q
FA
RGSK
EAA
LK
AV
M
L
---
SGVKQENLDLHTLNQ
P
LIA
DV
RA
RL
QPQQKY
IRGLF
C
GGTLC
D
E
T
MF
A
V
MEKH
G
-D
V
Y
SN
IQP
D
PEFR
L
QD
I
NR
S
IK
HT
F
LD
F
GDDDFT
N
GKPHPMIDPT
N
R
I
S
RL
I
E
E
AR
DP
E
VAV
I
V
M
D
F
VLGFG
S
HE
DP
V
G
S
T
I
E
A
IK
E
A
K
A
I
A
AA
E
G
R
E
L
II
L
A
Y
V
L
GT
D
L
D
TP
S
LE
QQ
S
QM
L
L
DAGVI
L
ASS
STN
T
G
LLA
REF
ICKGEEA
fig|679207.4.peg.2158
Escherichia coli MS 107-1
MSVKIVIK
P
N
T
Y
F
DSVSLM
S
IS
T
R
A
N
KL
D
GV
E
QA
F
V
A
M
A
T
E
M
NK
GV
L
KNL
GL
LTPELE
Q
A
K
NG
DL
M
I
V
I
N
G
K
AGAD
NE
Q
L
LV
E
I
EE
L
FN
S
K
A
Q
----
SG
SH
E
A
R
YA
T
----
IA
SA
K
K
HI
PE
S
NLA
V
ISV
N
G
L
F
AA
R
EA
R
QAL
QND
LNVM
L
FSDNVS
V
EDE
LA
LK
Q
LA
H
EKGLL
M
MGPDCGTAIING
A
A
L
C
F
G
N
A
V
R
RGNIG
IV
GASGTG
S
QEL
SV
RI
HEF
G
G
G
V
SQ
L
IGTGGRDLSE
K
IGG
LM
ML
D
A
I
G
ML
EN
D
P
Q
TE
I
IALISKPPAPAVARK
V
LERA
R
AC
R
KPVV
V
C
FLG
RV
E
TPVDEQ
G
L
Q
FA
RGSK
EAA
LK
AV
M
L
---
SGVKQENLDLHTLNQ
P
LIA
DV
RA
RL
QPQQKY
IRGLF
C
GGTLC
D
E
T
MF
A
V
MEKH
G
-D
V
Y
SN
IQP
D
PEFR
L
QD
I
NR
S
IK
HT
F
LD
F
GDDDFT
N
GKPHPMIDPT
N
R
I
S
RL
I
E
E
AR
DP
E
VAV
I
V
M
D
F
VLGFG
S
HE
DP
V
G
S
T
I
E
A
IK
E
A
K
A
I
A
AA
E
G
R
E
L
II
L
A
Y
V
L
GT
D
L
D
TP
S
LE
QQ
S
QM
L
L
DAGVI
L
ASS
STN
T
G
LLA
REF
ICKGEEA
fig|679204.3.peg.3754
Escherichia coli MS 145-7
MSVKIVIK
P
N
T
Y
F
DSVSLM
S
IS
T
R
A
N
KL
D
GV
E
QA
F
V
A
M
A
T
E
M
NK
GV
L
KNL
GL
LTPELE
Q
A
K
NG
DL
M
I
V
I
N
G
K
AGAD
NE
Q
L
LV
E
I
EE
L
FN
S
K
A
Q
----
SG
SH
E
A
R
YA
T
----
IA
SA
K
K
HI
PE
S
NLA
V
ISV
N
G
L
F
AA
R
EA
R
QAL
QND
LNVM
L
FSDNVS
V
EDE
LA
LK
Q
LA
H
EKGLL
M
MGPDCGTAIING
A
A
L
C
F
G
N
A
V
R
RGNIG
IV
GASGTG
S
QEL
SV
RI
HEF
G
G
G
V
SQ
L
IGTGGRDLSE
K
IGG
LM
ML
D
A
I
G
ML
EN
D
P
Q
TE
I
IALISKPPAPAVARK
V
LERA
R
AC
R
KPVV
V
C
FLG
RV
E
TPVDEQ
G
L
Q
FA
RGSK
EAA
LK
AV
M
L
---
SGVKQENLDLHTLNQ
P
LIA
DV
RA
RL
QPQQKY
IRGLF
C
GGTLC
D
E
T
MF
A
V
MEKH
G
-D
V
Y
SN
IQP
D
PEFR
L
QD
I
NR
S
IK
HT
F
LD
F
GDDDFT
N
GKPHPMIDPT
N
R
I
S
RL
I
E
E
AR
DP
E
VAV
I
V
M
D
F
VLGFG
S
HE
DP
V
G
S
T
I
E
A
IK
E
A
K
A
I
A
AA
E
G
R
E
L
II
L
A
Y
V
L
GT
D
L
D
TP
S
LE
QQ
S
QM
L
L
DAGVI
L
ASS
STN
T
G
LLA
REF
ICKGEEA
fig|340186.3.peg.1861
Escherichia coli E110019
MSVKIVIK
P
N
T
Y
F
DSVSLM
S
IS
T
R
A
N
KL
D
GV
E
QA
F
V
A
M
A
T
E
M
NK
GV
L
KNL
GL
LTPELE
Q
A
K
NG
DL
M
I
V
I
N
G
K
SGAD
NE
Q
L
LV
E
I
EE
L
FN
T
K
A
Q
----
SG
SH
E
A
R
YA
T
----
IA
SA
K
K
HI
PE
S
NLA
V
ISV
N
G
L
F
AA
R
EA
R
QAL
QND
LNVM
L
FSDNVS
V
EDE
LA
LK
Q
LA
H
EKGLL
M
MGPDCGTAIING
A
A
L
C
F
G
N
A
V
R
RGNIG
IV
GASGTG
S
QEL
SV
RI
HEF
G
G
G
V
SQ
L
IGTGGRDLSE
K
IGG
LM
ML
D
A
I
G
ML
EN
D
P
Q
TE
I
IALISKPPAPAVARK
V
LERA
R
AC
R
KPVV
V
C
FLG
RV
E
TPVDEQ
G
L
Q
FA
RGSK
EAA
LK
AV
M
L
---
SGVKQENLDLHTLNQ
P
LIA
DV
RA
RL
QPQQKY
IRGLF
C
GGTLC
D
E
T
MF
A
V
MEKH
G
-D
V
Y
SN
IQP
D
PEFR
L
QD
I
NR
S
IK
HT
F
LD
F
GDDDFT
N
GKPHPMIDPT
N
R
I
S
RL
I
E
E
AR
DP
E
VAV
I
V
M
D
F
VLGFG
S
HE
DP
V
G
S
T
I
E
A
IK
E
A
K
A
I
A
AA
E
G
R
E
L
II
L
A
Y
V
L
GT
D
L
D
TP
S
LE
QQ
S
QM
L
L
DAGVI
L
ASS
STN
T
G
LLA
REF
ICKGEEA
fig|340186.5.peg.1926
Escherichia coli E110019
MSVKIVIK
P
N
T
Y
F
DSVSLM
S
IS
T
R
A
N
KL
D
GV
E
QA
F
V
A
M
A
T
E
M
NK
GV
L
KNL
GL
LTPELE
Q
A
K
NG
DL
M
I
V
I
N
G
K
SGAD
NE
Q
L
LV
E
I
EE
L
FN
T
K
A
Q
----
SG
SH
E
A
R
YA
T
----
IA
SA
K
K
HI
PE
S
NLA
V
ISV
N
G
L
F
AA
R
EA
R
QAL
QND
LNVM
L
FSDNVS
V
EDE
LA
LK
Q
LA
H
EKGLL
M
MGPDCGTAIING
A
A
L
C
F
G
N
A
V
R
RGNIG
IV
GASGTG
S
QEL
SV
RI
HEF
G
G
G
V
SQ
L
IGTGGRDLSE
K
IGG
LM
ML
D
A
I
G
ML
EN
D
P
Q
TE
I
IALISKPPAPAVARK
V
LERA
R
AC
R
KPVV
V
C
FLG
RV
E
TPVDEQ
G
L
Q
FA
RGSK
EAA
LK
AV
M
L
---
SGVKQENLDLHTLNQ
P
LIA
DV
RA
RL
QPQQKY
IRGLF
C
GGTLC
D
E
T
MF
A
V
MEKH
G
-D
V
Y
SN
IQP
D
PEFR
L
QD
I
NR
S
IK
HT
F
LD
F
GDDDFT
N
GKPHPMIDPT
N
R
I
S
RL
I
E
E
AR
DP
E
VAV
I
V
M
D
F
VLGFG
S
HE
DP
V
G
S
T
I
E
A
IK
E
A
K
A
I
A
AA
E
G
R
E
L
II
L
A
Y
V
L
GT
D
L
D
TP
S
LE
QQ
S
QM
L
L
DAGVI
L
ASS
STN
T
G
LLA
REF
ICKGEEA
fig|331112.3.peg.355
Escherichia coli HS
MSVKIVIK
P
N
T
Y
F
DSVSLM
S
IS
T
R
A
N
KL
D
GV
E
QA
F
V
A
M
A
T
E
M
NK
GV
L
KNL
GL
LTPELE
Q
A
K
NG
DL
M
I
V
I
N
G
K
SGAD
NE
Q
L
LV
E
I
EE
L
FN
T
K
A
Q
----
SG
SH
E
A
R
YA
T
----
IA
SA
K
K
HI
PE
S
NLA
V
ISV
N
G
L
F
AA
R
EA
R
QAL
QND
LNVM
L
FSDNVS
V
EDE
LA
LK
Q
LA
H
EKGLL
M
MGPDCGTAIING
A
A
L
C
F
G
N
A
V
R
RGNIG
IV
GASGTG
S
QEL
SV
RI
HEF
G
G
G
V
SQ
L
IGTGGRDLSE
K
IGG
LM
ML
D
A
I
G
ML
EN
D
P
Q
TE
I
IALISKPPAPAVARK
V
LERA
R
AC
R
KPVV
V
C
FLG
RV
E
TPVDEQ
G
L
Q
FA
RGSK
EAA
LK
AV
M
L
---
SGVKQENLDLHTLNQ
P
LIA
DV
RA
RL
QPQQKY
IRGLF
C
GGTLC
D
E
T
MF
A
V
MEKH
G
-D
V
Y
SN
IQP
D
PEFR
L
QD
I
NR
S
IK
HT
F
LD
F
GDDDFT
N
GKPHPMIDPT
N
R
I
S
RL
I
E
E
AR
DP
E
VAV
I
V
M
D
F
VLGFG
S
HE
DP
V
G
S
T
I
E
A
IK
E
A
K
A
I
A
AA
E
G
R
E
L
II
L
A
Y
V
L
GT
D
L
D
TP
S
LE
QQ
S
QM
L
L
DAGVI
L
ASS
STN
T
G
LLA
REF
ICKGEEA
fig|331112.6.peg.374
Escherichia coli HS
MSVKIVIK
P
N
T
Y
F
DSVSLM
S
IS
T
R
A
N
KL
D
GV
E
QA
F
V
A
M
A
T
E
M
NK
GV
L
KNL
GL
LTPELE
Q
A
K
NG
DL
M
I
V
I
N
G
K
SGAD
NE
Q
L
LV
E
I
EE
L
FN
T
K
A
Q
----
SG
SH
E
A
R
YA
T
----
IA
SA
K
K
HI
PE
S
NLA
V
ISV
N
G
L
F
AA
R
EA
R
QAL
QND
LNVM
L
FSDNVS
V
EDE
LA
LK
Q
LA
H
EKGLL
M
MGPDCGTAIING
A
A
L
C
F
G
N
A
V
R
RGNIG
IV
GASGTG
S
QEL
SV
RI
HEF
G
G
G
V
SQ
L
IGTGGRDLSE
K
IGG
LM
ML
D
A
I
G
ML
EN
D
P
Q
TE
I
IALISKPPAPAVARK
V
LERA
R
AC
R
KPVV
V
C
FLG
RV
E
TPVDEQ
G
L
Q
FA
RGSK
EAA
LK
AV
M
L
---
SGVKQENLDLHTLNQ
P
LIA
DV
RA
RL
QPQQKY
IRGLF
C
GGTLC
D
E
T
MF
A
V
MEKH
G
-D
V
Y
SN
IQP
D
PEFR
L
QD
I
NR
S
IK
HT
F
LD
F
GDDDFT
N
GKPHPMIDPT
N
R
I
S
RL
I
E
E
AR
DP
E
VAV
I
V
M
D
F
VLGFG
S
HE
DP
V
G
S
T
I
E
A
IK
E
A
K
A
I
A
AA
E
G
R
E
L
II
L
A
Y
V
L
GT
D
L
D
TP
S
LE
QQ
S
QM
L
L
DAGVI
L
ASS
STN
T
G
LLA
REF
ICKGEEA
fig|573235.3.peg.351
Escherichia coli O26:H11 str. 11368
MSVKIVIK
P
N
T
Y
F
DSVSLM
S
IS
T
R
A
N
KL
D
GV
E
QA
F
V
A
M
A
T
E
M
NK
GV
L
KNL
GL
LTPELE
Q
A
K
NG
DL
M
I
V
I
N
G
K
SGAD
NE
Q
L
LV
E
I
EE
L
FN
T
K
A
Q
----
SG
SH
E
A
R
YA
T
----
IA
SA
K
K
HI
PE
S
NLA
V
ISV
N
G
L
F
AA
R
EA
R
QAL
QND
LNVM
L
FSDNVS
V
EDE
LA
LK
Q
LA
H
EKGLL
M
MGPDCGTAIING
A
A
L
C
F
G
N
A
V
R
RGNIG
IV
GASGTG
S
QEL
SV
RI
HEF
G
G
G
V
SQ
L
IGTGGRDLSE
K
IGG
LM
ML
D
A
I
G
ML
EN
D
P
Q
TE
I
IALISKPPAPAVARK
V
LERA
R
AC
R
KPVV
V
C
FLG
RV
E
TPVDEQ
G
L
Q
FA
RGSK
EAA
LK
AV
M
L
---
SGVKQENLDLHTLNQ
P
LIA
DV
RA
RL
QPQQKY
IRGLF
C
GGTLC
D
E
T
MF
A
V
MEKH
G
-D
V
Y
SN
IQP
D
PEFR
L
QD
I
NR
S
IK
HT
F
LD
F
GDDDFT
N
GKPHPMIDPT
N
R
I
S
RL
I
E
E
AR
DP
E
VAV
I
V
M
D
F
VLGFG
S
HE
DP
V
G
S
T
I
E
A
IK
E
A
K
A
I
A
AA
E
G
R
E
L
II
L
A
Y
V
L
GT
D
L
D
TP
S
LE
QQ
S
QM
L
L
DAGVI
L
ASS
STN
T
G
LLA
REF
ICKGEEA
fig|679205.4.peg.22
Escherichia coli MS 124-1
MSVKIVIK
P
N
T
Y
F
DSVSLM
S
IS
T
R
A
N
KL
D
GV
E
QA
F
V
A
M
A
T
E
M
NK
GV
L
KNL
GL
LTPELE
Q
A
K
NG
DL
M
I
V
I
N
G
K
SGAD
NE
Q
L
LV
E
I
EE
L
FN
T
K
A
Q
----
SG
SH
E
A
R
YA
T
----
IA
SA
K
K
HI
PE
S
NLA
V
ISV
N
G
L
F
AA
R
EA
R
QAL
QND
LNVM
L
FSDNVS
V
EDE
LA
LK
Q
LA
H
EKGLL
M
MGPDCGTAIING
A
A
L
C
F
G
N
A
V
R
RGNIG
IV
GASGTG
S
QEL
SV
RI
HEF
G
G
G
V
SQ
L
IGTGGRDLSE
K
IGG
LM
ML
D
A
I
G
ML
EN
D
P
Q
TE
I
I
V
LISKPPAPAVARK
V
LERA
R
AC
R
KPVV
V
C
FLG
RV
E
TPVDEQ
G
L
Q
FA
RGSK
EAA
LK
AV
M
L
---
SGVKQENLDLHTLNQ
P
LIA
DV
RA
RL
QPQQKY
IRGLF
C
GGTLC
D
E
T
MF
A
V
MEKH
G
-D
V
Y
SN
IQP
D
PEFR
L
QD
I
NR
S
IK
HT
F
LD
F
GDDDFT
N
GKPHPMIDPT
N
R
I
S
RL
I
E
E
AR
DP
E
VAV
I
V
M
D
F
VLGFG
S
HE
DP
V
G
S
T
I
E
A
IK
E
A
K
A
I
A
AA
E
G
R
E
L
II
L
A
Y
V
L
GT
D
L
D
TP
S
LE
QQ
S
QM
L
L
DAGVI
L
ASS
STN
T
G
LLA
REF
ICKGEEA
fig|749545.3.peg.1879
Escherichia coli MS 182-1
MSVKIVIK
P
N
T
Y
F
DSVSLM
S
IS
T
R
A
N
KL
D
GV
E
QA
F
V
A
M
A
T
E
M
NK
GV
L
KNL
GL
LTPELE
Q
A
K
NG
DL
M
I
V
I
N
G
K
SGAD
NE
Q
L
LV
E
I
EE
L
FN
T
K
A
Q
----
SG
SH
E
A
R
YA
T
----
IA
SA
K
K
HI
PE
S
NLA
V
ISV
N
G
L
F
AA
R
EA
R
QAL
QND
LNVM
L
FSDNVS
V
EDE
LA
LK
Q
LA
H
EKGLL
M
MGPDCGTAIING
A
A
L
C
F
G
N
A
V
R
RGNIG
IV
GASGTG
S
QEL
SV
RI
HEF
G
G
G
V
SQ
L
IGTGGRDLSE
K
IGG
LM
ML
D
A
I
G
ML
EN
D
P
Q
TE
I
I
V
LISKPPAPAVARK
V
LERA
R
AC
R
KPVV
V
C
FLG
RV
E
TPVDEQ
G
L
Q
FA
RGSK
EAA
LK
AV
M
L
---
SGVKQENLDLHTLNQ
P
LIA
DV
RA
RL
QPQQKY
IRGLF
C
GGTLC
D
E
T
MF
A
V
MEKH
G
-D
V
Y
SN
IQP
D
PEFR
L
QD
I
NR
S
IK
HT
F
LD
F
GDDDFT
N
GKPHPMIDPT
N
R
I
S
RL
I
E
E
AR
DP
E
VAV
I
V
M
D
F
VLGFG
S
HE
DP
V
G
S
T
I
E
A
IK
E
A
K
A
I
A
AA
E
G
R
E
L
II
L
A
Y
V
L
GT
D
L
D
TP
S
LE
QQ
S
QM
L
L
DAGVI
L
ASS
STN
T
G
LLA
REF
ICKGEEA
fig|749532.3.peg.146
Escherichia coli MS 78-1
MSVKIVIK
P
N
T
Y
F
DSVSLM
S
IS
T
R
A
N
KL
D
GV
E
QA
F
V
A
M
A
T
E
M
NK
GV
L
KNL
GL
LTPELE
Q
A
K
NG
DL
M
I
V
I
N
G
K
SGAD
NE
Q
L
LV
E
I
EE
L
FN
T
K
A
Q
----
SG
SH
E
A
R
YA
T
----
IA
SA
K
K
HI
PE
S
NLA
V
ISV
N
G
L
F
AA
R
EA
R
QAL
QND
LNVM
L
FSDNVS
V
EDE
LA
LK
Q
LA
H
EKGLL
M
MGPDCGTAIING
A
A
L
C
F
G
N
A
V
R
RGNIG
IV
GASGTG
S
QEL
SV
RI
HEF
G
G
G
V
SQ
L
IGTGGRDLSE
K
IGG
LM
ML
D
A
I
G
ML
EN
D
P
Q
TE
I
I
V
LISKPPAPAVARK
V
LERA
R
AC
R
KPVV
V
C
FLG
RV
E
TPVDEQ
G
L
Q
FA
RGSK
EAA
LK
AV
M
L
---
SGVKQENLDLHTLNQ
P
LIA
DV
RA
RL
QPQQKY
IRGLF
C
GGTLC
D
E
T
MF
A
V
MEKH
G
-D
V
Y
SN
IQP
D
PEFR
L
QD
I
NR
S
IK
HT
F
LD
F
GDDDFT
N
GKPHPMIDPT
N
R
I
S
RL
I
E
E
AR
DP
E
VAV
I
V
M
D
F
VLGFG
S
HE
DP
V
G
S
T
I
E
A
IK
E
A
K
A
I
A
AA
E
G
R
E
L
II
L
A
Y
V
L
GT
D
L
D
TP
S
LE
QQ
S
QM
L
L
DAGVI
L
ASS
STN
T
G
LLA
REF
ICKGEEA
fig|749533.3.peg.1480
Escherichia coli MS 84-1
MSVKIVIK
P
N
T
Y
F
DSVSLM
S
IS
T
R
A
N
KL
D
GV
E
QA
F
V
A
M
A
T
E
M
NK
GV
L
KNL
GL
LTPELE
Q
A
K
NG
DL
M
I
V
I
N
G
K
SGAD
NE
Q
L
LV
E
I
EE
L
FN
T
K
A
Q
----
SG
SH
E
A
R
YA
T
----
IA
SA
K
K
HI
PE
S
NLA
V
ISV
N
G
L
F
AA
R
EA
R
QAL
QND
LNVM
L
FSDNVS
V
EDE
LA
LK
Q
LA
H
EKGLL
M
MGPDCGTAIING
A
A
L
C
F
G
N
A
V
R
RGNIG
IV
GASGTG
S
QEL
SV
RI
HEF
G
G
G
V
SQ
L
IGTGGRDLSE
K
IGG
LM
ML
D
A
I
G
ML
EN
D
P
Q
TE
I
I
V
LISKPPAPAVARK
V
LERA
R
AC
R
KPVV
V
C
FLG
RV
E
TPVDEQ
G
L
Q
FA
RGSK
EAA
LK
AV
M
L
---
SGVKQENLDLHTLNQ
P
LIA
DV
RA
RL
QPQQKY
IRGLF
C
GGTLC
D
E
T
MF
A
V
MEKH
G
-D
V
Y
SN
IQP
D
PEFR
L
QD
I
NR
S
IK
HT
F
LD
F
GDDDFT
N
GKPHPMIDPT
N
R
I
S
RL
I
E
E
AR
DP
E
VAV
I
V
M
D
F
VLGFG
S
HE
DP
V
G
S
T
I
E
A
IK
E
A
K
A
I
A
AA
E
G
R
E
L
II
L
A
Y
V
L
GT
D
L
D
TP
S
LE
QQ
S
QM
L
L
DAGVI
L
ASS
STN
T
G
LLA
REF
ICKGEEA
fig|656408.3.peg.247
Escherichia coli H591
MSVKIVIK
P
N
T
Y
F
DSVSLM
S
IS
T
R
A
N
KL
D
GV
E
QA
F
V
A
M
A
T
E
M
NK
GV
L
KNL
GL
LTPELE
Q
A
K
NG
DL
M
I
V
I
N
G
K
SGAD
NE
Q
L
LA
E
I
EE
L
FN
S
K
A
Q
----
SG
SH
E
A
R
YA
T
----
IA
SA
K
K
HI
PE
S
NLA
V
ISV
N
G
L
F
AA
R
EA
R
QAL
QND
LNVM
L
FSDNVS
V
EDE
LA
LK
Q
LA
H
EKGLL
M
MGPDCGTAIING
A
A
L
C
F
G
N
A
V
R
RGNIG
IV
GASGTG
S
QEL
SV
RI
HEF
G
G
G
V
SQ
L
IGTGGRDLSE
K
IGG
LM
ML
D
A
I
G
ML
EN
D
P
Q
TE
I
I
V
LISKPPAPAVARK
V
LERA
R
AC
R
KPVV
V
C
FLG
RV
E
TPVDEQ
G
L
Q
FA
RGSK
EAA
LK
AV
M
L
---
SGVKQENLDLHTLNQ
P
LIA
DV
RA
RL
QPQQKY
IRGLF
C
GGTLC
D
E
T
MF
A
V
MEKH
G
-D
V
Y
SN
IQP
D
PEFR
L
QD
I
NR
S
IK
HT
F
LD
F
GDDDFT
N
GKPHPMIDPT
N
R
I
S
RL
I
E
E
AR
DP
E
VAV
I
V
M
D
F
VLGFG
S
HE
DP
V
G
S
T
I
E
A
IK
E
A
K
A
I
A
AA
E
G
R
E
L
II
L
A
Y
V
L
GT
D
L
D
TP
S
LE
QQ
S
QM
L
L
DAGVI
L
ASS
STN
T
G
LLA
REF
ICKGEEA
fig|679206.4.peg.238
Escherichia coli MS 119-7
MSVKIVIK
P
N
T
Y
F
DSVSLM
S
IS
T
R
A
N
KL
D
GV
E
QA
F
V
A
M
A
T
E
M
NK
GV
L
KNL
GL
LTPELE
Q
A
K
NG
DL
M
I
V
I
N
G
K
SGAD
NE
Q
L
LA
E
I
EE
L
FN
S
K
A
Q
----
SG
SH
E
A
R
YA
T
----
IA
SA
K
K
HI
PE
S
NLA
V
ISV
N
G
L
F
AA
R
EA
R
QAL
QND
LNVM
L
FSDNVS
V
EDE
LA
LK
Q
LA
H
EKGLL
M
MGPDCGTAIING
A
A
L
C
F
G
N
A
V
R
RGNIG
IV
GASGTG
S
QEL
SV
RI
HEF
G
G
G
V
SQ
L
IGTGGRDLSE
K
IGG
LM
ML
D
A
I
G
ML
EN
D
P
Q
TE
I
I
V
LISKPPAPAVARK
V
LERA
R
AC
R
KPVV
V
C
FLG
RV
E
TPVDEQ
G
L
Q
FA
RGSK
EAA
LK
AV
M
L
---
SGVKQENLDLHTLNQ
P
LIA
DV
RA
RL
QPQQKY
IRGLF
C
GGTLC
D
E
T
MF
A
V
MEKH
G
-D
V
Y
SN
IQP
D
PEFR
L
QD
I
NR
S
IK
HT
F
LD
F
GDDDFT
N
GKPHPMIDPT
N
R
I
S
RL
I
E
E
AR
DP
E
VAV
I
V
M
D
F
VLGFG
S
HE
DP
V
G
S
T
I
E
A
IK
E
A
K
A
I
A
AA
E
G
R
E
L
II
L
A
Y
V
L
GT
D
L
D
TP
S
LE
QQ
S
QM
L
L
DAGVI
L
ASS
STN
T
G
LLA
REF
ICKGEEA
fig|656443.3.peg.526
Escherichia coli TA271
MSVKIVIK
P
N
T
Y
F
DSVSLM
S
IS
T
R
A
N
KL
D
GV
E
QA
F
V
A
M
A
T
E
M
NK
GV
L
KNL
GL
LTPELE
Q
A
K
NG
DL
M
I
V
I
N
G
K
SGAD
NE
Q
L
LA
E
I
EE
L
FN
S
K
A
Q
----
SG
SH
E
A
R
YA
T
----
IA
SA
K
K
HI
PE
S
NLA
V
ISV
N
G
L
F
AA
R
EA
R
QAL
QND
LNVM
L
FSDNVS
V
EDE
LA
LK
Q
LA
H
EKGLL
M
MGPDCGTAIING
A
A
L
C
F
G
N
A
V
R
RGNIG
IV
GASGTG
S
QEL
SV
RI
HEF
G
G
G
V
SQ
L
IGTGGRDLSE
K
IGG
LM
ML
D
A
I
G
ML
EN
D
P
Q
TE
I
I
V
LISKPPAPAVARK
V
LERA
R
AC
R
KPVV
V
C
FLG
RV
E
TPVDEQ
G
L
Q
FA
RGSK
EAA
LK
AV
M
L
---
SGVKQENLDLHTLNQ
P
LIA
DV
RA
RL
QPQQKY
IRGLF
C
GGTLC
D
E
T
MF
A
V
MEKH
G
-D
V
Y
SN
IQP
D
PEFR
L
QD
I
NR
S
IK
HT
F
LD
F
GDDDFT
N
GKPHPMIDPT
N
R
I
S
RL
I
E
E
AR
DP
E
VAV
I
V
M
D
F
VLGFG
S
HE
DP
V
G
S
T
I
E
A
IK
E
A
K
A
I
A
AA
E
G
R
E
L
II
L
A
Y
V
L
GT
D
L
D
TP
S
LE
QQ
S
QM
L
L
DAGVI
L
ASS
STN
T
G
LLA
REF
ICKGEEA
fig|585396.4.peg.360
Escherichia coli O111:H- str. 11128
MSVKIVIK
P
N
T
Y
F
DSVSLM
S
IS
T
R
A
N
KL
D
GV
E
QA
F
V
A
M
A
T
E
M
NK
GV
L
KNL
GL
LTPELE
Q
A
K
NG
DL
M
I
V
I
N
G
K
SGAD
NE
Q
L
LV
E
I
EE
L
FN
T
K
A
Q
----
SG
SH
E
A
R
YA
T
----
IA
SA
K
K
HI
PE
S
NLA
V
ISV
N
G
L
F
AA
R
EA
R
QAL
QND
LNVM
L
FSDNVS
V
EDE
LA
LK
Q
LA
H
EKGLL
M
MGPDCGTAIING
A
A
L
C
F
G
N
A
V
R
RGNIG
IV
GASGTG
S
QEL
SV
RI
HEF
G
G
G
V
SQ
L
IGTGGRDLSE
K
IGG
LM
ML
D
A
I
G
ML
EN
D
P
Q
TE
I
IALISKPPAPAVARK
V
LERA
R
AC
R
KPVV
V
C
FLG
RV
E
TPVDEQ
G
L
Q
FA
RGSK
EAA
LK
AV
M
L
---
SGVKQENLDLHTLNQ
P
LIA
DV
RA
RL
QPQQKY
IRGLF
C
GGTLC
D
E
T
MF
A
V
MEKH
G
-D
V
Y
SN
IPP
D
PEFR
L
QD
I
NR
S
IK
HT
F
LD
F
GDDDFT
N
GKPHPMIDPT
N
R
I
S
RL
I
E
E
AR
DP
E
VAV
I
V
M
D
F
VLGFG
S
HE
DP
V
G
S
T
I
E
A
IK
E
A
K
A
I
A
AA
E
G
R
E
L
II
L
A
Y
V
L
GT
D
L
D
TP
S
LE
QQ
S
QM
L
L
DAGVI
L
ASS
STN
T
G
LLA
REF
ICKGEEA
fig|670888.3.peg.896
Escherichia coli 1827-70
MSVKIVIK
P
N
T
Y
F
DSVSLM
S
IS
A
R
A
N
KL
D
GV
E
QA
F
V
A
M
A
T
E
M
NK
GV
L
KNL
GL
LTPELE
Q
A
K
NG
DL
M
I
V
I
N
G
K
SGAD
NE
Q
L
LV
E
I
EE
L
FN
T
K
A
Q
----
SG
SH
E
A
R
YA
T
----
IA
SA
K
K
HI
PE
S
NLA
V
ISV
N
G
L
F
AA
R
EA
R
QAL
QND
LNVM
L
FSDNVS
V
EDE
LA
LK
Q
LA
H
EKGLL
M
MGPDCGTAIING
A
A
L
C
F
G
N
A
V
R
RGNIG
IV
GASGTG
S
QEL
SV
RI
HEF
G
G
G
V
SQ
L
IGTGGRDLSE
K
IGG
LM
ML
D
A
I
G
ML
EN
D
P
Q
TE
I
IALISKPPAPAVARK
V
LERA
R
AC
R
KPVV
V
C
FLG
RV
E
TPVDEQ
G
L
Q
FA
RGSK
EAA
LK
AV
M
L
---
SGVKQENLDLHTLNQ
P
LIA
DV
RA
RL
QPQQKY
IRGLF
C
GGTLC
D
E
T
MF
A
V
MEKH
G
-D
V
Y
SN
IQP
D
PEFR
L
KD
I
NR
S
IK
HT
F
LD
F
GDDDFT
N
GKPHPMIDPT
N
R
I
S
RL
I
E
E
AR
DP
E
VAV
I
V
M
D
F
VLGFG
S
HE
DP
V
G
S
T
I
E
A
IK
E
A
K
A
I
A
AA
E
G
R
E
L
II
L
A
Y
V
L
GT
D
L
D
TP
S
LE
QQ
S
QM
L
L
DAGVI
L
ASS
STN
T
G
LLA
REF
ICKGEEA
fig|331111.12.peg.655
Escherichia coli E24377A
MSVKIVIK
P
N
T
Y
F
DSVSLM
S
IS
T
R
A
N
KL
D
GV
E
QA
F
V
A
M
A
T
E
M
NK
GV
L
KNL
GL
LTPELE
Q
A
K
NG
DL
M
I
V
I
N
G
K
SGAD
NE
Q
L
LA
E
I
EE
L
FN
S
K
A
Q
----
SG
SH
E
A
R
YA
T
----
IA
SA
K
K
HI
PE
S
NLA
V
ISV
N
G
L
F
AA
R
EA
R
QAL
QND
LNVM
L
FSDNVS
V
EDE
LA
LK
Q
LA
H
EKGLL
M
MGPDCGTAIING
A
A
L
C
F
G
N
A
V
R
RGNIG
IV
GASGTG
S
QEL
SV
RI
HEF
G
G
G
F
SQ
L
IGTGGRDLSE
K
IGG
LM
ML
D
A
I
G
ML
EN
D
P
Q
TE
I
I
V
LISKPPAPAVARK
V
LERA
R
AC
R
KPVV
V
C
FLG
RV
E
TPVDEQ
G
L
Q
FA
RGSK
EAA
LK
AV
M
L
---
SGVKQENLDLHTLNQ
P
LIA
DV
RA
RL
QPQQKY
IRGLF
C
GGTLC
D
E
T
MF
A
V
MEKH
G
-D
V
Y
SN
IQP
D
PEFR
L
QD
I
NR
S
IK
HT
F
LD
F
GDDDFT
N
GKPHPMIDPT
N
R
I
S
RL
I
E
E
AR
DP
E
VAV
I
V
M
D
F
VLGFG
S
HE
DP
V
G
S
T
I
E
A
IK
E
A
K
A
I
A
AA
E
G
R
E
L
II
L
A
Y
V
L
GT
D
L
D
TP
S
LE
QQ
S
QM
L
L
DAGVI
L
ASS
STN
T
G
LLA
REF
ICKGEEA
fig|331111.3.peg.2889
Escherichia coli E24377A
MSVKIVIK
P
N
T
Y
F
DSVSLM
S
IS
T
R
A
N
KL
D
GV
E
QA
F
V
A
M
A
T
E
M
NK
GV
L
KNL
GL
LTPELE
Q
A
K
NG
DL
M
I
V
I
N
G
K
SGAD
NE
Q
L
LA
E
I
EE
L
FN
S
K
A
Q
----
SG
SH
E
A
R
YA
T
----
IA
SA
K
K
HI
PE
S
NLA
V
ISV
N
G
L
F
AA
R
EA
R
QAL
QND
LNVM
L
FSDNVS
V
EDE
LA
LK
Q
LA
H
EKGLL
M
MGPDCGTAIING
A
A
L
C
F
G
N
A
V
R
RGNIG
IV
GASGTG
S
QEL
SV
RI
HEF
G
G
G
F
SQ
L
IGTGGRDLSE
K
IGG
LM
ML
D
A
I
G
ML
EN
D
P
Q
TE
I
I
V
LISKPPAPAVARK
V
LERA
R
AC
R
KPVV
V
C
FLG
RV
E
TPVDEQ
G
L
Q
FA
RGSK
EAA
LK
AV
M
L
---
SGVKQENLDLHTLNQ
P
LIA
DV
RA
RL
QPQQKY
IRGLF
C
GGTLC
D
E
T
MF
A
V
MEKH
G
-D
V
Y
SN
IQP
D
PEFR
L
QD
I
NR
S
IK
HT
F
LD
F
GDDDFT
N
GKPHPMIDPT
N
R
I
S
RL
I
E
E
AR
DP
E
VAV
I
V
M
D
F
VLGFG
S
HE
DP
V
G
S
T
I
E
A
IK
E
A
K
A
I
A
AA
E
G
R
E
L
II
L
A
Y
V
L
GT
D
L
D
TP
S
LE
QQ
S
QM
L
L
DAGVI
L
ASS
STN
T
G
LLA
REF
ICKGEEA
fig|358709.5.peg.2913
Escherichia coli 101-1
MSVKIVIK
P
N
T
Y
F
DSVSLM
S
IS
T
R
A
N
KL
D
GV
E
QA
F
V
A
M
A
T
E
M
NK
GV
L
KNL
GL
LTPELE
Q
A
K
NG
DL
M
I
V
I
N
G
K
SGAD
NE
Q
L
LA
E
I
EE
L
FN
S
K
A
Q
----
SG
SH
E
A
R
YA
T
----
IA
SA
K
K
HI
PE
SS
LA
V
ISV
N
G
L
F
AA
R
EA
R
QAL
QND
LNVM
L
FSDNVS
V
EDE
LA
LK
Q
LA
H
EKGLL
M
MGPDCGTAIING
A
A
L
C
F
G
N
A
V
R
RGNIG
IV
GASGTG
S
QEL
SV
RI
HEF
G
G
G
V
SQ
L
IGTGGRDLSE
K
IGG
LM
ML
D
A
I
G
ML
EN
D
P
Q
TE
I
I
V
LISKPPAPAVARK
V
LERA
R
AC
R
KPVV
V
C
FLG
RV
E
TPVDEQ
G
L
Q
FA
RGSK
EAA
LK
AV
M
L
---
SGVKQENLDLHTLNQ
P
LIA
DV
RA
RL
QPQQKY
IRGLF
C
GGTLC
D
E
T
MF
A
V
MEKH
G
-D
V
Y
SN
IQP
D
PEFR
L
QD
I
NR
S
IK
HT
F
LD
F
GDDDFT
N
GKPHPMIDPT
N
R
I
S
RL
I
E
E
AR
DP
E
VAV
I
V
M
D
F
VLGFG
S
HE
DP
V
G
S
T
I
E
A
IK
E
A
K
A
I
A
AA
E
G
R
E
L
II
L
A
Y
V
L
GT
D
L
D
TP
S
LE
QQ
S
QM
L
L
DAGVI
L
ASS
STN
T
G
LLA
REF
ICKGEEA
fig|413997.3.peg.295
Escherichia coli B str. REL606
MSVKIVIK
P
N
T
Y
F
DSVSLM
S
IS
T
R
A
N
KL
D
GV
E
QA
F
V
A
M
A
T
E
M
NK
GV
L
KNL
GL
LTPELE
Q
A
K
NG
DL
M
I
V
I
N
G
K
SGAD
NE
Q
L
LA
E
I
EE
L
FN
S
K
A
Q
----
SG
SH
E
A
R
YA
T
----
IA
SA
K
K
HI
PE
SS
LA
V
ISV
N
G
L
F
AA
R
EA
R
QAL
QND
LNVM
L
FSDNVS
V
EDE
LA
LK
Q
LA
H
EKGLL
M
MGPDCGTAIING
A
A
L
C
F
G
N
A
V
R
RGNIG
IV
GASGTG
S
QEL
SV
RI
HEF
G
G
G
V
SQ
L
IGTGGRDLSE
K
IGG
LM
ML
D
A
I
G
ML
EN
D
P
Q
TE
I
I
V
LISKPPAPAVARK
V
LERA
R
AC
R
KPVV
V
C
FLG
RV
E
TPVDEQ
G
L
Q
FA
RGSK
EAA
LK
AV
M
L
---
SGVKQENLDLHTLNQ
P
LIA
DV
RA
RL
QPQQKY
IRGLF
C
GGTLC
D
E
T
MF
A
V
MEKH
G
-D
V
Y
SN
IQP
D
PEFR
L
QD
I
NR
S
IK
HT
F
LD
F
GDDDFT
N
GKPHPMIDPT
N
R
I
S
RL
I
E
E
AR
DP
E
VAV
I
V
M
D
F
VLGFG
S
HE
DP
V
G
S
T
I
E
A
IK
E
A
K
A
I
A
AA
E
G
R
E
L
II
L
A
Y
V
L
GT
D
L
D
TP
S
LE
QQ
S
QM
L
L
DAGVI
L
ASS
STN
T
G
LLA
REF
ICKGEEA
fig|469008.4.peg.3448
Escherichia coli BL21(DE3)
MSVKIVIK
P
N
T
Y
F
DSVSLM
S
IS
T
R
A
N
KL
D
GV
E
QA
F
V
A
M
A
T
E
M
NK
GV
L
KNL
GL
LTPELE
Q
A
K
NG
DL
M
I
V
I
N
G
K
SGAD
NE
Q
L
LA
E
I
EE
L
FN
S
K
A
Q
----
SG
SH
E
A
R
YA
T
----
IA
SA
K
K
HI
PE
SS
LA
V
ISV
N
G
L
F
AA
R
EA
R
QAL
QND
LNVM
L
FSDNVS
V
EDE
LA
LK
Q
LA
H
EKGLL
M
MGPDCGTAIING
A
A
L
C
F
G
N
A
V
R
RGNIG
IV
GASGTG
S
QEL
SV
RI
HEF
G
G
G
V
SQ
L
IGTGGRDLSE
K
IGG
LM
ML
D
A
I
G
ML
EN
D
P
Q
TE
I
I
V
LISKPPAPAVARK
V
LERA
R
AC
R
KPVV
V
C
FLG
RV
E
TPVDEQ
G
L
Q
FA
RGSK
EAA
LK
AV
M
L
---
SGVKQENLDLHTLNQ
P
LIA
DV
RA
RL
QPQQKY
IRGLF
C
GGTLC
D
E
T
MF
A
V
MEKH
G
-D
V
Y
SN
IQP
D
PEFR
L
QD
I
NR
S
IK
HT
F
LD
F
GDDDFT
N
GKPHPMIDPT
N
R
I
S
RL
I
E
E
AR
DP
E
VAV
I
V
M
D
F
VLGFG
S
HE
DP
V
G
S
T
I
E
A
IK
E
A
K
A
I
A
AA
E
G
R
E
L
II
L
A
Y
V
L
GT
D
L
D
TP
S
LE
QQ
S
QM
L
L
DAGVI
L
ASS
STN
T
G
LLA
REF
ICKGEEA
fig|749547.3.peg.25
Escherichia coli MS 187-1
MSVKIVIK
P
N
T
Y
F
DSVSLM
S
IS
T
R
A
N
KL
D
GV
E
QA
F
V
A
M
A
T
E
M
NK
GV
L
KNL
GL
LTPELE
Q
A
K
NG
DL
M
I
V
I
N
G
K
SGAD
NE
Q
L
LA
E
I
EE
L
FN
S
K
A
Q
----
SG
SH
E
A
R
YA
T
----
IA
SA
K
K
HI
PE
SS
LA
V
ISV
N
G
L
F
AA
R
EA
R
QAL
QND
LNVM
L
FSDNVS
V
EDE
LA
LK
Q
LA
H
EKGLL
M
MGPDCGTAIING
A
A
L
C
F
G
N
A
V
R
RGNIG
IV
GASGTG
S
QEL
SV
RI
HEF
G
G
G
V
SQ
L
IGTGGRDLSE
K
IGG
LM
ML
D
A
I
G
ML
EN
D
P
Q
TE
I
I
V
LISKPPAPAVARK
V
LERA
R
AC
R
KPVV
V
C
FLG
RV
E
TPVDEQ
G
L
Q
FA
RGSK
EAA
LK
AV
M
L
---
SGVKQENLDLHTLNQ
P
LIA
DV
RA
RL
QPQQKY
IRGLF
C
GGTLC
D
E
T
MF
A
V
MEKH
G
-D
V
Y
SN
IQP
D
PEFR
L
QD
I
NR
S
IK
HT
F
LD
F
GDDDFT
N
GKPHPMIDPT
N
R
I
S
RL
I
E
E
AR
DP
E
VAV
I
V
M
D
F
VLGFG
S
HE
DP
V
G
S
T
I
E
A
IK
E
A
K
A
I
A
AA
E
G
R
E
L
II
L
A
Y
V
L
GT
D
L
D
TP
S
LE
QQ
S
QM
L
L
DAGVI
L
ASS
STN
T
G
LLA
REF
ICKGEEA
fig|749531.3.peg.1340
Escherichia coli MS 69-1
MSVKIVIK
P
N
T
Y
F
DSVSLM
S
IS
T
R
A
N
KL
D
GV
E
QA
F
V
A
M
A
T
E
M
NK
GV
L
KNL
GL
LTPELE
Q
A
K
NG
DL
M
I
V
I
N
G
K
SGAD
NE
Q
L
LV
E
I
EE
L
FN
T
K
A
Q
----
T
G
SH
E
A
R
YA
T
----
IA
SA
K
K
HI
PE
S
NLA
V
ISV
N
G
L
F
AA
R
EA
R
QAL
QND
LNVM
L
FSDNVS
V
EDE
LA
LK
Q
LA
H
EKGLL
M
MGPDCGTAIING
A
A
L
C
F
G
N
A
V
R
RGNIG
IV
GASGTG
S
QEL
SV
RI
HEF
G
G
G
V
SQ
L
IGTGGRDLSE
K
IGG
LM
ML
D
A
I
G
ML
EN
D
P
Q
TE
I
I
V
LISKPPAPAVARK
V
LERA
R
AC
R
KPVV
V
C
FLG
RV
E
TPVDEQ
G
L
Q
FA
RGSK
EAA
LK
AV
M
L
---
SGVKQEHLDLHTLNQ
P
LIA
DV
RA
RL
QPQQKY
IRGLF
C
GGTLC
D
E
T
MF
A
V
MEKH
G
-D
V
Y
SN
IQP
D
PEFR
L
QD
I
NR
S
IK
HT
F
LD
F
GDDDFT
N
GKPHPMIDPT
N
R
I
S
RL
I
E
E
AR
DP
E
VAV
I
V
M
D
F
VLGFG
S
HE
DP
V
G
S
T
I
E
A
IK
E
A
K
A
I
A
AA
E
G
R
E
L
II
L
A
Y
V
L
GT
D
L
D
TP
S
LE
QQ
S
QM
L
L
DAGVI
L
ASS
STN
T
G
LLA
REF
ICKGEEA
fig|481805.3.peg.3546
Escherichia coli ATCC 8739
MSVKIVIK
P
N
T
Y
F
DSVSLM
S
IS
T
R
A
N
KL
D
GV
E
QA
F
V
A
M
A
T
E
M
NK
GV
L
KNL
GL
LTPELE
Q
A
K
NG
DL
M
I
V
I
N
G
K
SGAD
NE
Q
L
LV
E
I
EE
L
FN
T
K
A
Q
----
SG
SH
E
A
R
YA
T
----
IG
SA
K
K
HI
PE
S
NLA
V
ISV
N
G
L
F
AA
R
EA
R
QAL
QND
LNVM
L
FSDNVS
V
EDE
LA
LK
Q
LA
H
EKGLL
M
MGPDCGTAIING
A
A
L
C
F
G
N
A
V
R
RGNIG
IV
GASGTG
S
QEL
SV
RI
HEF
G
G
G
V
SQ
L
IGTGGRDLSE
K
IGG
LM
ML
D
A
I
G
ML
EN
D
P
Q
TE
I
IALISKPPAPAVARK
V
LERA
R
AC
R
KPVV
V
C
FL
D
RG
E
TPVDEQ
G
L
Q
FA
RGTK
EAA
LK
AV
M
L
---
SGVKQENLDLHTLNQ
P
LIA
DV
RA
RL
QPQQKY
IRGLF
C
GGTLC
D
E
T
MF
A
V
MEKH
G
-D
V
Y
SN
IQP
D
PEFR
L
KD
I
NR
S
IK
HT
F
LD
F
GDDDFT
N
GKPHPMIDPT
N
R
I
S
RL
I
E
E
AR
DP
E
VAV
I
V
M
D
F
VLGFG
S
HE
DP
V
G
S
T
I
E
T
IK
E
A
K
A
I
A
AA
E
G
R
E
L
II
L
A
Y
V
L
GT
D
L
D
TP
S
LE
QQ
S
QM
L
L
DAGVI
L
ASS
STN
T
G
LLA
REF
ICKGEEA
fig|481805.6.peg.3528
Escherichia coli ATCC 8739
MSVKIVIK
P
N
T
Y
F
DSVSLM
S
IS
T
R
A
N
KL
D
GV
E
QA
F
V
A
M
A
T
E
M
NK
GV
L
KNL
GL
LTPELE
Q
A
K
NG
DL
M
I
V
I
N
G
K
SGAD
NE
Q
L
LV
E
I
EE
L
FN
T
K
A
Q
----
SG
SH
E
A
R
YA
T
----
IG
SA
K
K
HI
PE
S
NLA
V
ISV
N
G
L
F
AA
R
EA
R
QAL
QND
LNVM
L
FSDNVS
V
EDE
LA
LK
Q
LA
H
EKGLL
M
MGPDCGTAIING
A
A
L
C
F
G
N
A
V
R
RGNIG
IV
GASGTG
S
QEL
SV
RI
HEF
G
G
G
V
SQ
L
IGTGGRDLSE
K
IGG
LM
ML
D
A
I
G
ML
EN
D
P
Q
TE
I
IALISKPPAPAVARK
V
LERA
R
AC
R
KPVV
V
C
FL
D
RG
E
TPVDEQ
G
L
Q
FA
RGTK
EAA
LK
AV
M
L
---
SGVKQENLDLHTLNQ
P
LIA
DV
RA
RL
QPQQKY
IRGLF
C
GGTLC
D
E
T
MF
A
V
MEKH
G
-D
V
Y
SN
IQP
D
PEFR
L
KD
I
NR
S
IK
HT
F
LD
F
GDDDFT
N
GKPHPMIDPT
N
R
I
S
RL
I
E
E
AR
DP
E
VAV
I
V
M
D
F
VLGFG
S
HE
DP
V
G
S
T
I
E
T
IK
E
A
K
A
I
A
AA
E
G
R
E
L
II
L
A
Y
V
L
GT
D
L
D
TP
S
LE
QQ
S
QM
L
L
DAGVI
L
ASS
STN
T
G
LLA
REF
ICKGEEA
fig|536056.3.peg.3476
Escherichia coli DH1
MSVKIVIK
P
N
T
Y
F
DSVSLM
S
IS
T
R
A
N
KL
D
GV
E
QA
F
V
A
M
A
T
E
M
NK
GV
L
KNL
GL
LTPELE
Q
A
K
NG
DL
M
I
V
I
N
G
K
SGAD
NE
Q
L
LV
E
I
EE
L
FN
T
K
A
Q
----
SG
SH
E
A
R
YA
T
----
IG
SA
K
K
HI
PE
S
NLA
V
ISV
N
G
L
F
AA
R
EA
R
QAL
QND
LNVM
L
FSDNVS
V
EDE
LA
LK
Q
LA
H
EKGLL
M
MGPDCGTAIING
A
A
L
C
F
G
N
A
V
R
RGNIG
IV
GASGTG
S
QEL
SV
RI
HEF
G
G
G
V
SQ
L
IGTGGRDLSE
K
IGG
LM
ML
D
A
I
G
ML
EN
D
P
Q
TE
I
IALISKPPAPAVARK
V
LERA
R
AC
R
KPVV
V
C
FL
D
RG
E
TPVDEQ
G
L
Q
FA
RGTK
EAA
LK
AV
M
L
---
SGVKQENLDLHTLNQ
P
LIA
DV
RA
RL
QPQQKY
IRGLF
C
GGTLC
D
E
T
MF
A
V
MEKH
G
-D
V
Y
SN
IQP
D
PEFR
L
KD
I
NR
S
IK
HT
F
LD
F
GDDDFT
N
GKPHPMIDPT
N
R
I
S
RL
I
E
E
AR
DP
E
VAV
I
V
M
D
F
VLGFG
S
HE
DP
V
G
S
T
I
E
T
IK
E
A
K
A
I
A
AA
E
G
R
E
L
II
L
A
Y
V
L
GT
D
L
D
TP
S
LE
QQ
S
QM
L
L
DAGVI
L
ASS
STN
T
G
LLA
REF
ICKGEEA
fig|316401.4.peg.435
Escherichia coli ETEC H10407
MSVKIVIK
P
N
T
Y
F
DSVSLM
S
IS
T
R
A
N
KL
D
GV
E
QA
F
V
A
M
A
T
E
M
NK
GV
L
KNL
GL
LTPELE
Q
A
K
NG
DL
M
I
V
I
N
G
K
SGAD
NE
Q
L
LV
E
I
EE
L
FN
T
K
A
Q
----
SG
SH
E
A
R
YA
T
----
IG
SA
K
K
HI
PE
S
NLA
V
ISV
N
G
L
F
AA
R
EA
R
QAL
QND
LNVM
L
FSDNVS
V
EDE
LA
LK
Q
LA
H
EKGLL
M
MGPDCGTAIING
A
A
L
C
F
G
N
A
V
R
RGNIG
IV
GASGTG
S
QEL
SV
RI
HEF
G
G
G
V
SQ
L
IGTGGRDLSE
K
IGG
LM
ML
D
A
I
G
ML
EN
D
P
Q
TE
I
IALISKPPAPAVARK
V
LERA
R
AC
R
KPVV
V
C
FL
D
RG
E
TPVDEQ
G
L
Q
FA
RGTK
EAA
LK
AV
M
L
---
SGVKQENLDLHTLNQ
P
LIA
DV
RA
RL
QPQQKY
IRGLF
C
GGTLC
D
E
T
MF
A
V
MEKH
G
-D
V
Y
SN
IQP
D
PEFR
L
KD
I
NR
S
IK
HT
F
LD
F
GDDDFT
N
GKPHPMIDPT
N
R
I
S
RL
I
E
E
AR
DP
E
VAV
I
V
M
D
F
VLGFG
S
HE
DP
V
G
S
T
I
E
T
IK
E
A
K
A
I
A
AA
E
G
R
E
L
II
L
A
Y
V
L
GT
D
L
D
TP
S
LE
QQ
S
QM
L
L
DAGVI
L
ASS
STN
T
G
LLA
REF
ICKGEEA
fig|656414.3.peg.508
Escherichia coli H736
MSVKIVIK
P
N
T
Y
F
DSVSLM
S
IS
T
R
A
N
KL
D
GV
E
QA
F
V
A
M
A
T
E
M
NK
GV
L
KNL
GL
LTPELE
Q
A
K
NG
DL
M
I
V
I
N
G
K
SGAD
NE
Q
L
LV
E
I
EE
L
FN
T
K
A
Q
----
SG
SH
E
A
R
YA
T
----
IG
SA
K
K
HI
PE
S
NLA
V
ISV
N
G
L
F
AA
R
EA
R
QAL
QND
LNVM
L
FSDNVS
V
EDE
LA
LK
Q
LA
H
EKGLL
M
MGPDCGTAIING
A
A
L
C
F
G
N
A
V
R
RGNIG
IV
GASGTG
S
QEL
SV
RI
HEF
G
G
G
V
SQ
L
IGTGGRDLSE
K
IGG
LM
ML
D
A
I
G
ML
EN
D
P
Q
TE
I
IALISKPPAPAVARK
V
LERA
R
AC
R
KPVV
V
C
FL
D
RG
E
TPVDEQ
G
L
Q
FA
RGTK
EAA
LK
AV
M
L
---
SGVKQENLDLHTLNQ
P
LIA
DV
RA
RL
QPQQKY
IRGLF
C
GGTLC
D
E
T
MF
A
V
MEKH
G
-D
V
Y
SN
IQP
D
PEFR
L
KD
I
NR
S
IK
HT
F
LD
F
GDDDFT
N
GKPHPMIDPT
N
R
I
S
RL
I
E
E
AR
DP
E
VAV
I
V
M
D
F
VLGFG
S
HE
DP
V
G
S
T
I
E
T
IK
E
A
K
A
I
A
AA
E
G
R
E
L
II
L
A
Y
V
L
GT
D
L
D
TP
S
LE
QQ
S
QM
L
L
DAGVI
L
ASS
STN
T
G
LLA
REF
ICKGEEA
fig|83333.1.peg.317
Escherichia coli K12
MSVKIVIK
P
N
T
Y
F
DSVSLM
S
IS
T
R
A
N
KL
D
GV
E
QA
F
V
A
M
A
T
E
M
NK
GV
L
KNL
GL
LTPELE
Q
A
K
NG
DL
M
I
V
I
N
G
K
SGAD
NE
Q
L
LV
E
I
EE
L
FN
T
K
A
Q
----
SG
SH
E
A
R
YA
T
----
IG
SA
K
K
HI
PE
S
NLA
V
ISV
N
G
L
F
AA
R
EA
R
QAL
QND
LNVM
L
FSDNVS
V
EDE
LA
LK
Q
LA
H
EKGLL
M
MGPDCGTAIING
A
A
L
C
F
G
N
A
V
R
RGNIG
IV
GASGTG
S
QEL
SV
RI
HEF
G
G
G
V
SQ
L
IGTGGRDLSE
K
IGG
LM
ML
D
A
I
G
ML
EN
D
P
Q
TE
I
IALISKPPAPAVARK
V
LERA
R
AC
R
KPVV
V
C
FL
D
RG
E
TPVDEQ
G
L
Q
FA
RGTK
EAA
LK
AV
M
L
---
SGVKQENLDLHTLNQ
P
LIA
DV
RA
RL
QPQQKY
IRGLF
C
GGTLC
D
E
T
MF
A
V
MEKH
G
-D
V
Y
SN
IQP
D
PEFR
L
KD
I
NR
S
IK
HT
F
LD
F
GDDDFT
N
GKPHPMIDPT
N
R
I
S
RL
I
E
E
AR
DP
E
VAV
I
V
M
D
F
VLGFG
S
HE
DP
V
G
S
T
I
E
T
IK
E
A
K
A
I
A
AA
E
G
R
E
L
II
L
A
Y
V
L
GT
D
L
D
TP
S
LE
QQ
S
QM
L
L
DAGVI
L
ASS
STN
T
G
LLA
REF
ICKGEEA
fig|749537.3.peg.369
Escherichia coli MS 115-1
MSVKIVIK
P
N
T
Y
F
DSVSLM
S
IS
T
R
A
N
KL
D
GV
E
QA
F
V
A
M
A
T
E
M
NK
GV
L
KNL
GL
LTPELE
Q
A
K
NG
DL
M
I
V
I
N
G
K
SGAD
NE
Q
L
LV
E
I
EE
L
FN
T
K
A
Q
----
SG
SH
E
A
R
YA
T
----
IG
SA
K
K
HI
PE
S
NLA
V
ISV
N
G
L
F
AA
R
EA
R
QAL
QND
LNVM
L
FSDNVS
V
EDE
LA
LK
Q
LA
H
EKGLL
M
MGPDCGTAIING
A
A
L
C
F
G
N
A
V
R
RGNIG
IV
GASGTG
S
QEL
SV
RI
HEF
G
G
G
V
SQ
L
IGTGGRDLSE
K
IGG
LM
ML
D
A
I
G
ML
EN
D
P
Q
TE
I
IALISKPPAPAVARK
V
LERA
R
AC
R
KPVV
V
C
FL
D
RG
E
TPVDEQ
G
L
Q
FA
RGTK
EAA
LK
AV
M
L
---
SGVKQENLDLHTLNQ
P
LIA
DV
RA
RL
QPQQKY
IRGLF
C
GGTLC
D
E
T
MF
A
V
MEKH
G
-D
V
Y
SN
IQP
D
PEFR
L
KD
I
NR
S
IK
HT
F
LD
F
GDDDFT
N
GKPHPMIDPT
N
R
I
S
RL
I
E
E
AR
DP
E
VAV
I
V
M
D
F
VLGFG
S
HE
DP
V
G
S
T
I
E
T
IK
E
A
K
A
I
A
AA
E
G
R
E
L
II
L
A
Y
V
L
GT
D
L
D
TP
S
LE
QQ
S
QM
L
L
DAGVI
L
ASS
STN
T
G
LLA
REF
ICKGEEA
fig|749538.3.peg.98
Escherichia coli MS 116-1
MSVKIVIK
P
N
T
Y
F
DSVSLM
S
IS
T
R
A
N
KL
D
GV
E
QA
F
V
A
M
A
T
E
M
NK
GV
L
KNL
GL
LTPELE
Q
A
K
NG
DL
M
I
V
I
N
G
K
SGAD
NE
Q
L
LV
E
I
EE
L
FN
T
K
A
Q
----
SG
SH
E
A
R
YA
T
----
IG
SA
K
K
HI
PE
S
NLA
V
ISV
N
G
L
F
AA
R
EA
R
QAL
QND
LNVM
L
FSDNVS
V
EDE
LA
LK
Q
LA
H
EKGLL
M
MGPDCGTAIING
A
A
L
C
F
G
N
A
V
R
RGNIG
IV
GASGTG
S
QEL
SV
RI
HEF
G
G
G
V
SQ
L
IGTGGRDLSE
K
IGG
LM
ML
D
A
I
G
ML
EN
D
P
Q
TE
I
IALISKPPAPAVARK
V
LERA
R
AC
R
KPVV
V
C
FL
D
RG
E
TPVDEQ
G
L
Q
FA
RGTK
EAA
LK
AV
M
L
---
SGVKQENLDLHTLNQ
P
LIA
DV
RA
RL
QPQQKY
IRGLF
C
GGTLC
D
E
T
MF
A
V
MEKH
G
-D
V
Y
SN
IQP
D
PEFR
L
KD
I
NR
S
IK
HT
F
LD
F
GDDDFT
N
GKPHPMIDPT
N
R
I
S
RL
I
E
E
AR
DP
E
VAV
I
V
M
D
F
VLGFG
S
HE
DP
V
G
S
T
I
E
T
IK
E
A
K
A
I
A
AA
E
G
R
E
L
II
L
A
Y
V
L
GT
D
L
D
TP
S
LE
QQ
S
QM
L
L
DAGVI
L
ASS
STN
T
G
LLA
REF
ICKGEEA
fig|749540.3.peg.1963
Escherichia coli MS 146-1
MSVKIVIK
P
N
T
Y
F
DSVSLM
S
IS
T
R
A
N
KL
D
GV
E
QA
F
V
A
M
A
T
E
M
NK
GV
L
KNL
GL
LTPELE
Q
A
K
NG
DL
M
I
V
I
N
G
K
SGAD
NE
Q
L
LV
E
I
EE
L
FN
T
K
A
Q
----
SG
SH
E
A
R
YA
T
----
IG
SA
K
K
HI
PE
S
NLA
V
ISV
N
G
L
F
AA
R
EA
R
QAL
QND
LNVM
L
FSDNVS
V
EDE
LA
LK
Q
LA
H
EKGLL
M
MGPDCGTAIING
A
A
L
C
F
G
N
A
V
R
RGNIG
IV
GASGTG
S
QEL
SV
RI
HEF
G
G
G
V
SQ
L
IGTGGRDLSE
K
IGG
LM
ML
D
A
I
G
ML
EN
D
P
Q
TE
I
IALISKPPAPAVARK
V
LERA
R
AC
R
KPVV
V
C
FL
D
RG
E
TPVDEQ
G
L
Q
FA
RGTK
EAA
LK
AV
M
L
---
SGVKQENLDLHTLNQ
P
LIA
DV
RA
RL
QPQQKY
IRGLF
C
GGTLC
D
E
T
MF
A
V
MEKH
G
-D
V
Y
SN
IQP
D
PEFR
L
KD
I
NR
S
IK
HT
F
LD
F
GDDDFT
N
GKPHPMIDPT
N
R
I
S
RL
I
E
E
AR
DP
E
VAV
I
V
M
D
F
VLGFG
S
HE
DP
V
G
S
T
I
E
T
IK
E
A
K
A
I
A
AA
E
G
R
E
L
II
L
A
Y
V
L
GT
D
L
D
TP
S
LE
QQ
S
QM
L
L
DAGVI
L
ASS
STN
T
G
LLA
REF
ICKGEEA
fig|749544.3.peg.1288
Escherichia coli MS 175-1
MSVKIVIK
P
N
T
Y
F
DSVSLM
S
IS
T
R
A
N
KL
D
GV
E
QA
F
V
A
M
A
T
E
M
NK
GV
L
KNL
GL
LTPELE
Q
A
K
NG
DL
M
I
V
I
N
G
K
SGAD
NE
Q
L
LV
E
I
EE
L
FN
T
K
A
Q
----
SG
SH
E
A
R
YA
T
----
IG
SA
K
K
HI
PE
S
NLA
V
ISV
N
G
L
F
AA
R
EA
R
QAL
QND
LNVM
L
FSDNVS
V
EDE
LA
LK
Q
LA
H
EKGLL
M
MGPDCGTAIING
A
A
L
C
F
G
N
A
V
R
RGNIG
IV
GASGTG
S
QEL
SV
RI
HEF
G
G
G
V
SQ
L
IGTGGRDLSE
K
IGG
LM
ML
D
A
I
G
ML
EN
D
P
Q
TE
I
IALISKPPAPAVARK
V
LERA
R
AC
R
KPVV
V
C
FL
D
RG
E
TPVDEQ
G
L
Q
FA
RGTK
EAA
LK
AV
M
L
---
SGVKQENLDLHTLNQ
P
LIA
DV
RA
RL
QPQQKY
IRGLF
C
GGTLC
D
E
T
MF
A
V
MEKH
G
-D
V
Y
SN
IQP
D
PEFR
L
KD
I
NR
S
IK
HT
F
LD
F
GDDDFT
N
GKPHPMIDPT
N
R
I
S
RL
I
E
E
AR
DP
E
VAV
I
V
M
D
F
VLGFG
S
HE
DP
V
G
S
T
I
E
T
IK
E
A
K
A
I
A
AA
E
G
R
E
L
II
L
A
Y
V
L
GT
D
L
D
TP
S
LE
QQ
S
QM
L
L
DAGVI
L
ASS
STN
T
G
LLA
REF
ICKGEEA
fig|749548.3.peg.74
Escherichia coli MS 196-1
MSVKIVIK
P
N
T
Y
F
DSVSLM
S
IS
T
R
A
N
KL
D
GV
E
QA
F
V
A
M
A
T
E
M
NK
GV
L
KNL
GL
LTPELE
Q
A
K
NG
DL
M
I
V
I
N
G
K
SGAD
NE
Q
L
LV
E
I
EE
L
FN
T
K
A
Q
----
SG
SH
E
A
R
YA
T
----
IG
SA
K
K
HI
PE
S
NLA
V
ISV
N
G
L
F
AA
R
EA
R
QAL
QND
LNVM
L
FSDNVS
V
EDE
LA
LK
Q
LA
H
EKGLL
M
MGPDCGTAIING
A
A
L
C
F
G
N
A
V
R
RGNIG
IV
GASGTG
S
QEL
SV
RI
HEF
G
G
G
V
SQ
L
IGTGGRDLSE
K
IGG
LM
ML
D
A
I
G
ML
EN
D
P
Q
TE
I
IALISKPPAPAVARK
V
LERA
R
AC
R
KPVV
V
C
FL
D
RG
E
TPVDEQ
G
L
Q
FA
RGTK
EAA
LK
AV
M
L
---
SGVKQENLDLHTLNQ
P
LIA
DV
RA
RL
QPQQKY
IRGLF
C
GGTLC
D
E
T
MF
A
V
MEKH
G
-D
V
Y
SN
IQP
D
PEFR
L
KD
I
NR
S
IK
HT
F
LD
F
GDDDFT
N
GKPHPMIDPT
N
R
I
S
RL
I
E
E
AR
DP
E
VAV
I
V
M
D
F
VLGFG
S
HE
DP
V
G
S
T
I
E
T
IK
E
A
K
A
I
A
AA
E
G
R
E
L
II
L
A
Y
V
L
GT
D
L
D
TP
S
LE
QQ
S
QM
L
L
DAGVI
L
ASS
STN
T
G
LLA
REF
ICKGEEA
fig|316407.3.peg.309
Escherichia coli W3110
MSVKIVIK
P
N
T
Y
F
DSVSLM
S
IS
T
R
A
N
KL
D
GV
E
QA
F
V
A
M
A
T
E
M
NK
GV
L
KNL
GL
LTPELE
Q
A
K
NG
DL
M
I
V
I
N
G
K
SGAD
NE
Q
L
LV
E
I
EE
L
FN
T
K
A
Q
----
SG
SH
E
A
R
YA
T
----
IG
SA
K
K
HI
PE
S
NLA
V
ISV
N
G
L
F
AA
R
EA
R
QAL
QND
LNVM
L
FSDNVS
V
EDE
LA
LK
Q
LA
H
EKGLL
M
MGPDCGTAIING
A
A
L
C
F
G
N
A
V
R
RGNIG
IV
GASGTG
S
QEL
SV
RI
HEF
G
G
G
V
SQ
L
IGTGGRDLSE
K
IGG
LM
ML
D
A
I
G
ML
EN
D
P
Q
TE
I
IALISKPPAPAVARK
V
LERA
R
AC
R
KPVV
V
C
FL
D
RG
E
TPVDEQ
G
L
Q
FA
RGTK
EAA
LK
AV
M
L
---
SGVKQENLDLHTLNQ
P
LIA
DV
RA
RL
QPQQKY
IRGLF
C
GGTLC
D
E
T
MF
A
V
MEKH
G
-D
V
Y
SN
IQP
D
PEFR
L
KD
I
NR
S
IK
HT
F
LD
F
GDDDFT
N
GKPHPMIDPT
N
R
I
S
RL
I
E
E
AR
DP
E
VAV
I
V
M
D
F
VLGFG
S
HE
DP
V
G
S
T
I
E
T
IK
E
A
K
A
I
A
AA
E
G
R
E
L
II
L
A
Y
V
L
GT
D
L
D
TP
S
LE
QQ
S
QM
L
L
DAGVI
L
ASS
STN
T
G
LLA
REF
ICKGEEA
fig|316385.5.peg.298
Escherichia coli str. K-12 substr. DH10B
MSVKIVIK
P
N
T
Y
F
DSVSLM
S
IS
T
R
A
N
KL
D
GV
E
QA
F
V
A
M
A
T
E
M
NK
GV
L
KNL
GL
LTPELE
Q
A
K
NG
DL
M
I
V
I
N
G
K
SGAD
NE
Q
L
LV
E
I
EE
L
FN
T
K
A
Q
----
SG
SH
E
A
R
YA
T
----
IG
SA
K
K
HI
PE
S
NLA
V
ISV
N
G
L
F
AA
R
EA
R
QAL
QND
LNVM
L
FSDNVS
V
EDE
LA
LK
Q
LA
H
EKGLL
M
MGPDCGTAIING
A
A
L
C
F
G
N
A
V
R
RGNIG
IV
GASGTG
S
QEL
SV
RI
HEF
G
G
G
V
SQ
L
IGTGGRDLSE
K
IGG
LM
ML
D
A
I
G
ML
EN
D
P
Q
TE
I
IALISKPPAPAVARK
V
LERA
R
AC
R
KPVV
V
C
FL
D
RG
E
TPVDEQ
G
L
Q
FA
RGTK
EAA
LK
AV
M
L
---
SGVKQENLDLHTLNQ
P
LIA
DV
RA
RL
QPQQKY
IRGLF
C
GGTLC
D
E
T
MF
A
V
MEKH
G
-D
V
Y
SN
IQP
D
PEFR
L
KD
I
NR
S
IK
HT
F
LD
F
GDDDFT
N
GKPHPMIDPT
N
R
I
S
RL
I
E
E
AR
DP
E
VAV
I
V
M
D
F
VLGFG
S
HE
DP
V
G
S
T
I
E
T
IK
E
A
K
A
I
A
AA
E
G
R
E
L
II
L
A
Y
V
L
GT
D
L
D
TP
S
LE
QQ
S
QM
L
L
DAGVI
L
ASS
STN
T
G
LLA
REF
ICKGEEA
fig|316385.7.peg.306
Escherichia coli str. K-12 substr. DH10B
MSVKIVIK
P
N
T
Y
F
DSVSLM
S
IS
T
R
A
N
KL
D
GV
E
QA
F
V
A
M
A
T
E
M
NK
GV
L
KNL
GL
LTPELE
Q
A
K
NG
DL
M
I
V
I
N
G
K
SGAD
NE
Q
L
LV
E
I
EE
L
FN
T
K
A
Q
----
SG
SH
E
A
R
YA
T
----
IG
SA
K
K
HI
PE
S
NLA
V
ISV
N
G
L
F
AA
R
EA
R
QAL
QND
LNVM
L
FSDNVS
V
EDE
LA
LK
Q
LA
H
EKGLL
M
MGPDCGTAIING
A
A
L
C
F
G
N
A
V
R
RGNIG
IV
GASGTG
S
QEL
SV
RI
HEF
G
G
G
V
SQ
L
IGTGGRDLSE
K
IGG
LM
ML
D
A
I
G
ML
EN
D
P
Q
TE
I
IALISKPPAPAVARK
V
LERA
R
AC
R
KPVV
V
C
FL
D
RG
E
TPVDEQ
G
L
Q
FA
RGTK
EAA
LK
AV
M
L
---
SGVKQENLDLHTLNQ
P
LIA
DV
RA
RL
QPQQKY
IRGLF
C
GGTLC
D
E
T
MF
A
V
MEKH
G
-D
V
Y
SN
IQP
D
PEFR
L
KD
I
NR
S
IK
HT
F
LD
F
GDDDFT
N
GKPHPMIDPT
N
R
I
S
RL
I
E
E
AR
DP
E
VAV
I
V
M
D
F
VLGFG
S
HE
DP
V
G
S
T
I
E
T
IK
E
A
K
A
I
A
AA
E
G
R
E
L
II
L
A
Y
V
L
GT
D
L
D
TP
S
LE
QQ
S
QM
L
L
DAGVI
L
ASS
STN
T
G
LLA
REF
ICKGEEA
fig|511145.12.peg.327
Escherichia coli str. K-12 substr. MG1655
MSVKIVIK
P
N
T
Y
F
DSVSLM
S
IS
T
R
A
N
KL
D
GV
E
QA
F
V
A
M
A
T
E
M
NK
GV
L
KNL
GL
LTPELE
Q
A
K
NG
DL
M
I
V
I
N
G
K
SGAD
NE
Q
L
LV
E
I
EE
L
FN
T
K
A
Q
----
SG
SH
E
A
R
YA
T
----
IG
SA
K
K
HI
PE
S
NLA
V
ISV
N
G
L
F
AA
R
EA
R
QAL
QND
LNVM
L
FSDNVS
V
EDE
LA
LK
Q
LA
H
EKGLL
M
MGPDCGTAIING
A
A
L
C
F
G
N
A
V
R
RGNIG
IV
GASGTG
S
QEL
SV
RI
HEF
G
G
G
V
SQ
L
IGTGGRDLSE
K
IGG
LM
ML
D
A
I
G
ML
EN
D
P
Q
TE
I
IALISKPPAPAVARK
V
LERA
R
AC
R
KPVV
V
C
FL
D
RG
E
TPVDEQ
G
L
Q
FA
RGTK
EAA
LK
AV
M
L
---
SGVKQENLDLHTLNQ
P
LIA
DV
RA
RL
QPQQKY
IRGLF
C
GGTLC
D
E
T
MF
A
V
MEKH
G
-D
V
Y
SN
IQP
D
PEFR
L
KD
I
NR
S
IK
HT
F
LD
F
GDDDFT
N
GKPHPMIDPT
N
R
I
S
RL
I
E
E
AR
DP
E
VAV
I
V
M
D
F
VLGFG
S
HE
DP
V
G
S
T
I
E
T
IK
E
A
K
A
I
A
AA
E
G
R
E
L
II
L
A
Y
V
L
GT
D
L
D
TP
S
LE
QQ
S
QM
L
L
DAGVI
L
ASS
STN
T
G
LLA
REF
ICKGEEA
fig|511145.6.peg.325
Escherichia coli str. K-12 substr. MG1655
MSVKIVIK
P
N
T
Y
F
DSVSLM
S
IS
T
R
A
N
KL
D
GV
E
QA
F
V
A
M
A
T
E
M
NK
GV
L
KNL
GL
LTPELE
Q
A
K
NG
DL
M
I
V
I
N
G
K
SGAD
NE
Q
L
LV
E
I
EE
L
FN
T
K
A
Q
----
SG
SH
E
A
R
YA
T
----
IG
SA
K
K
HI
PE
S
NLA
V
ISV
N
G
L
F
AA
R
EA
R
QAL
QND
LNVM
L
FSDNVS
V
EDE
LA
LK
Q
LA
H
EKGLL
M
MGPDCGTAIING
A
A
L
C
F
G
N
A
V
R
RGNIG
IV
GASGTG
S
QEL
SV
RI
HEF
G
G
G
V
SQ
L
IGTGGRDLSE
K
IGG
LM
ML
D
A
I
G
ML
EN
D
P
Q
TE
I
IALISKPPAPAVARK
V
LERA
R
AC
R
KPVV
V
C
FL
D
RG
E
TPVDEQ
G
L
Q
FA
RGTK
EAA
LK
AV
M
L
---
SGVKQENLDLHTLNQ
P
LIA
DV
RA
RL
QPQQKY
IRGLF
C
GGTLC
D
E
T
MF
A
V
MEKH
G
-D
V
Y
SN
IQP
D
PEFR
L
KD
I
NR
S
IK
HT
F
LD
F
GDDDFT
N
GKPHPMIDPT
N
R
I
S
RL
I
E
E
AR
DP
E
VAV
I
V
M
D
F
VLGFG
S
HE
DP
V
G
S
T
I
E
T
IK
E
A
K
A
I
A
AA
E
G
R
E
L
II
L
A
Y
V
L
GT
D
L
D
TP
S
LE
QQ
S
QM
L
L
DAGVI
L
ASS
STN
T
G
LLA
REF
ICKGEEA
fig|550672.3.peg.334
Escherichia coli B088
MSVKIVIK
P
N
T
Y
F
DSVSLM
S
IS
T
R
A
N
KL
D
GV
E
QA
F
V
A
M
A
T
E
M
NK
GV
L
KNL
GL
LTPELE
Q
A
K
NG
DL
M
I
V
I
N
G
K
AGAD
NE
Q
L
LV
E
I
EE
L
FN
T
K
A
Q
----
SG
SH
E
A
R
YA
T
----
IA
SA
K
K
HI
PE
S
NLA
V
ISV
N
G
L
F
AA
R
EA
R
QAL
QND
LNVM
L
FSDNVS
V
EDE
LA
LK
Q
LA
H
EKGLL
M
MGPDCGTAIING
A
A
L
C
F
G
N
A
V
R
RGNIG
IV
GASGTG
S
QEL
SV
RI
HEF
G
G
G
V
SQ
L
IGTGGRDLSE
K
IGG
LM
ML
D
A
I
G
ML
EN
D
P
Q
TE
I
I
V
LISKPPAPAVARK
V
LERA
R
AC
R
KPVV
V
C
FLG
RG
E
TPVDEQ
G
L
Q
FA
RGSK
EAA
LK
AV
M
L
---
SGVKQEHLDLHTLNQ
P
LIA
DV
RA
RL
QPQQKY
IRGLF
C
GGTLC
D
E
T
MF
A
V
MEKH
G
-D
V
Y
SN
IQP
D
PEFR
L
QD
I
NR
S
IK
HT
F
LD
F
GDDDFT
N
GKPHPMIDPT
N
R
I
S
RL
I
E
E
AR
DP
E
VAV
I
V
M
D
F
VLGFG
S
HE
DP
V
G
S
T
I
E
A
IK
E
A
K
A
I
A
AA
E
G
R
E
L
II
L
A
Y
V
L
GT
D
L
D
TP
S
LE
QQ
S
QM
L
L
DAGVI
L
ASS
STN
T
G
LLA
REF
ICKGEEA
fig|344601.3.peg.1861
Escherichia coli B171
MSVKIVIK
P
N
T
Y
F
DSVSLM
S
IS
T
R
A
N
KL
D
GV
E
QA
F
V
A
M
A
T
E
M
NK
GV
L
KNL
GL
LTPELE
Q
A
K
NG
DL
M
I
V
I
N
G
K
AGAD
NE
Q
L
LV
E
I
EE
L
FN
T
K
A
Q
----
SG
SH
E
A
R
YA
T
----
IA
SA
K
K
HI
PE
S
NLA
V
ISV
N
G
L
F
AA
R
EA
R
QAL
QND
LNVM
L
FSDNVS
V
EDE
LA
LK
Q
LA
H
EKGLL
M
MGPDCGTAIING
A
A
L
C
F
G
N
A
V
R
RGNIG
IV
GASGTG
S
QEL
SV
RI
HEF
G
G
G
V
SQ
L
IGTGGRDLSE
K
IGG
LM
ML
D
A
I
G
ML
EN
D
P
Q
TE
I
I
V
LISKPPAPAVARK
V
LERA
R
AC
R
KPVV
V
C
FLG
RG
E
TPVDEQ
G
L
Q
FA
RGSK
EAA
LK
AV
M
L
---
SGVKQEHLDLHTLNQ
P
LIA
DV
RA
RL
QPQQKY
IRGLF
C
GGTLC
D
E
T
MF
A
V
MEKH
G
-D
V
Y
SN
IQP
D
PEFR
L
QD
I
NR
S
IK
HT
F
LD
F
GDDDFT
N
GKPHPMIDPT
N
R
I
S
RL
I
E
E
AR
DP
E
VAV
I
V
M
D
F
VLGFG
S
HE
DP
V
G
S
T
I
E
A
IK
E
A
K
A
I
A
AA
E
G
R
E
L
II
L
A
Y
V
L
GT
D
L
D
TP
S
LE
QQ
S
QM
L
L
DAGVI
L
ASS
STN
T
G
LLA
REF
ICKGEEA
fig|344601.5.peg.1939
Escherichia coli B171
MSVKIVIK
P
N
T
Y
F
DSVSLM
S
IS
T
R
A
N
KL
D
GV
E
QA
F
V
A
M
A
T
E
M
NK
GV
L
KNL
GL
LTPELE
Q
A
K
NG
DL
M
I
V
I
N
G
K
AGAD
NE
Q
L
LV
E
I
EE
L
FN
T
K
A
Q
----
SG
SH
E
A
R
YA
T
----
IA
SA
K
K
HI
PE
S
NLA
V
ISV
N
G
L
F
AA
R
EA
R
QAL
QND
LNVM
L
FSDNVS
V
EDE
LA
LK
Q
LA
H
EKGLL
M
MGPDCGTAIING
A
A
L
C
F
G
N
A
V
R
RGNIG
IV
GASGTG
S
QEL
SV
RI
HEF
G
G
G
V
SQ
L
IGTGGRDLSE
K
IGG
LM
ML
D
A
I
G
ML
EN
D
P
Q
TE
I
I
V
LISKPPAPAVARK
V
LERA
R
AC
R
KPVV
V
C
FLG
RG
E
TPVDEQ
G
L
Q
FA
RGSK
EAA
LK
AV
M
L
---
SGVKQEHLDLHTLNQ
P
LIA
DV
RA
RL
QPQQKY
IRGLF
C
GGTLC
D
E
T
MF
A
V
MEKH
G
-D
V
Y
SN
IQP
D
PEFR
L
QD
I
NR
S
IK
HT
F
LD
F
GDDDFT
N
GKPHPMIDPT
N
R
I
S
RL
I
E
E
AR
DP
E
VAV
I
V
M
D
F
VLGFG
S
HE
DP
V
G
S
T
I
E
A
IK
E
A
K
A
I
A
AA
E
G
R
E
L
II
L
A
Y
V
L
GT
D
L
D
TP
S
LE
QQ
S
QM
L
L
DAGVI
L
ASS
STN
T
G
LLA
REF
ICKGEEA
fig|340185.3.peg.2703
Escherichia coli E22
MSVKIVIK
P
N
T
Y
F
DSVSLM
S
IS
T
R
A
N
KL
D
GV
E
QA
F
V
A
M
A
T
E
M
NK
GV
L
KNL
GL
LTPELE
Q
A
K
NG
DL
M
I
V
I
N
G
K
AGAD
NE
Q
L
LV
E
I
EE
L
FN
T
K
A
Q
----
SG
SH
E
A
R
YA
T
----
IA
SA
K
K
HI
PE
S
NLA
V
ISV
N
G
L
F
AA
R
EA
R
QAL
QND
LNVM
L
FSDNVS
V
EDE
LA
LK
Q
LA
H
EKGLL
M
MGPDCGTAIING
A
A
L
C
F
G
N
A
V
R
RGNIG
IV
GASGTG
S
QEL
SV
RI
HEF
G
G
G
V
SQ
L
IGTGGRDLSE
K
IGG
LM
ML
D
A
I
G
ML
EN
D
P
Q
TE
I
I
V
LISKPPAPAVARK
V
LERA
R
AC
R
KPVV
V
C
FLG
RG
E
TPVDEQ
G
L
Q
FA
RGSK
EAA
LK
AV
M
L
---
SGVKQEHLDLHTLNQ
P
LIA
DV
RA
RL
QPQQKY
IRGLF
C
GGTLC
D
E
T
MF
A
V
MEKH
G
-D
V
Y
SN
IQP
D
PEFR
L
QD
I
NR
S
IK
HT
F
LD
F
GDDDFT
N
GKPHPMIDPT
N
R
I
S
RL
I
E
E
AR
DP
E
VAV
I
V
M
D
F
VLGFG
S
HE
DP
V
G
S
T
I
E
A
IK
E
A
K
A
I
A
AA
E
G
R
E
L
II
L
A
Y
V
L
GT
D
L
D
TP
S
LE
QQ
S
QM
L
L
DAGVI
L
ASS
STN
T
G
LLA
REF
ICKGEEA
fig|340185.4.peg.2847
Escherichia coli E22
MSVKIVIK
P
N
T
Y
F
DSVSLM
S
IS
T
R
A
N
KL
D
GV
E
QA
F
V
A
M
A
T
E
M
NK
GV
L
KNL
GL
LTPELE
Q
A
K
NG
DL
M
I
V
I
N
G
K
AGAD
NE
Q
L
LV
E
I
EE
L
FN
T
K
A
Q
----
SG
SH
E
A
R
YA
T
----
IA
SA
K
K
HI
PE
S
NLA
V
ISV
N
G
L
F
AA
R
EA
R
QAL
QND
LNVM
L
FSDNVS
V
EDE
LA
LK
Q
LA
H
EKGLL
M
MGPDCGTAIING
A
A
L
C
F
G
N
A
V
R
RGNIG
IV
GASGTG
S
QEL
SV
RI
HEF
G
G
G
V
SQ
L
IGTGGRDLSE
K
IGG
LM
ML
D
A
I
G
ML
EN
D
P
Q
TE
I
I
V
LISKPPAPAVARK
V
LERA
R
AC
R
KPVV
V
C
FLG
RG
E
TPVDEQ
G
L
Q
FA
RGSK
EAA
LK
AV
M
L
---
SGVKQEHLDLHTLNQ
P
LIA
DV
RA
RL
QPQQKY
IRGLF
C
GGTLC
D
E
T
MF
A
V
MEKH
G
-D
V
Y
SN
IQP
D
PEFR
L
QD
I
NR
S
IK
HT
F
LD
F
GDDDFT
N
GKPHPMIDPT
N
R
I
S
RL
I
E
E
AR
DP
E
VAV
I
V
M
D
F
VLGFG
S
HE
DP
V
G
S
T
I
E
A
IK
E
A
K
A
I
A
AA
E
G
R
E
L
II
L
A
Y
V
L
GT
D
L
D
TP
S
LE
QQ
S
QM
L
L
DAGVI
L
ASS
STN
T
G
LLA
REF
ICKGEEA
fig|585034.4.peg.311
Escherichia coli IAI1
MSVKIVIK
P
N
T
Y
F
DSVSLM
S
IS
T
R
A
N
KL
D
GV
E
QA
F
V
A
M
A
T
E
M
NK
GV
L
KNL
GL
LTPELE
Q
A
K
NG
DL
M
I
V
I
N
G
K
AGAD
NE
Q
L
LV
E
I
EE
L
FN
T
K
A
Q
----
SG
SH
E
A
R
YA
T
----
IA
SA
K
K
HI
PE
S
NLA
V
ISV
N
G
L
F
AA
R
EA
R
QAL
QND
LNVM
L
FSDNVS
V
EDE
LA
LK
Q
LA
H
EKGLL
M
MGPDCGTAIING
A
A
L
C
F
G
N
A
V
R
RGNIG
IV
GASGTG
S
QEL
SV
RI
HEF
G
G
G
V
SQ
L
IGTGGRDLSE
K
IGG
LM
ML
D
A
I
G
ML
EN
D
P
Q
TE
I
I
V
LISKPPAPAVARK
V
LERA
R
AC
R
KPVV
V
C
FLG
RG
E
TPVDEQ
G
L
Q
FA
RGSK
EAA
LK
AV
M
L
---
SGVKQEHLDLHTLNQ
P
LIA
DV
RA
RL
QPQQKY
IRGLF
C
GGTLC
D
E
T
MF
A
V
MEKH
G
-D
V
Y
SN
IQP
D
PEFR
L
QD
I
NR
S
IK
HT
F
LD
F
GDDDFT
N
GKPHPMIDPT
N
R
I
S
RL
I
E
E
AR
DP
E
VAV
I
V
M
D
F
VLGFG
S
HE
DP
V
G
S
T
I
E
A
IK
E
A
K
A
I
A
AA
E
G
R
E
L
II
L
A
Y
V
L
GT
D
L
D
TP
S
LE
QQ
S
QM
L
L
DAGVI
L
ASS
STN
T
G
LLA
REF
ICKGEEA
fig|585034.5.peg.310
Escherichia coli IAI1
MSVKIVIK
P
N
T
Y
F
DSVSLM
S
IS
T
R
A
N
KL
D
GV
E
QA
F
V
A
M
A
T
E
M
NK
GV
L
KNL
GL
LTPELE
Q
A
K
NG
DL
M
I
V
I
N
G
K
AGAD
NE
Q
L
LV
E
I
EE
L
FN
T
K
A
Q
----
SG
SH
E
A
R
YA
T
----
IA
SA
K
K
HI
PE
S
NLA
V
ISV
N
G
L
F
AA
R
EA
R
QAL
QND
LNVM
L
FSDNVS
V
EDE
LA
LK
Q
LA
H
EKGLL
M
MGPDCGTAIING
A
A
L
C
F
G
N
A
V
R
RGNIG
IV
GASGTG
S
QEL
SV
RI
HEF
G
G
G
V
SQ
L
IGTGGRDLSE
K
IGG
LM
ML
D
A
I
G
ML
EN
D
P
Q
TE
I
I
V
LISKPPAPAVARK
V
LERA
R
AC
R
KPVV
V
C
FLG
RG
E
TPVDEQ
G
L
Q
FA
RGSK
EAA
LK
AV
M
L
---
SGVKQEHLDLHTLNQ
P
LIA
DV
RA
RL
QPQQKY
IRGLF
C
GGTLC
D
E
T
MF
A
V
MEKH
G
-D
V
Y
SN
IQP
D
PEFR
L
QD
I
NR
S
IK
HT
F
LD
F
GDDDFT
N
GKPHPMIDPT
N
R
I
S
RL
I
E
E
AR
DP
E
VAV
I
V
M
D
F
VLGFG
S
HE
DP
V
G
S
T
I
E
A
IK
E
A
K
A
I
A
AA
E
G
R
E
L
II
L
A
Y
V
L
GT
D
L
D
TP
S
LE
QQ
S
QM
L
L
DAGVI
L
ASS
STN
T
G
LLA
REF
ICKGEEA
fig|595495.4.peg.559
Escherichia coli KO11
MSVKIVIK
P
N
T
Y
F
DSVSLM
S
IS
T
R
A
N
KL
D
GV
E
QA
F
V
A
M
A
T
E
M
NK
GV
L
KNL
GL
LTPELE
Q
A
K
NG
DL
M
I
V
I
N
G
K
AGAD
NE
Q
L
LV
E
I
EE
L
FN
T
K
A
Q
----
SG
SH
E
A
R
YA
T
----
IA
SA
K
K
HI
PE
S
NLA
V
ISV
N
G
L
F
AA
R
EA
R
QAL
QND
LNVM
L
FSDNVS
V
EDE
LA
LK
Q
LA
H
EKGLL
M
MGPDCGTAIING
A
A
L
C
F
G
N
A
V
R
RGNIG
IV
GASGTG
S
QEL
SV
RI
HEF
G
G
G
V
SQ
L
IGTGGRDLSE
K
IGG
LM
ML
D
A
I
G
ML
EN
D
P
Q
TE
I
I
V
LISKPPAPAVARK
V
LERA
R
AC
R
KPVV
V
C
FLG
RG
E
TPVDEQ
G
L
Q
FA
RGSK
EAA
LK
AV
M
L
---
SGVKQEHLDLHTLNQ
P
LIA
DV
RA
RL
QPQQKY
IRGLF
C
GGTLC
D
E
T
MF
A
V
MEKH
G
-D
V
Y
SN
IQP
D
PEFR
L
QD
I
NR
S
IK
HT
F
LD
F
GDDDFT
N
GKPHPMIDPT
N
R
I
S
RL
I
E
E
AR
DP
E
VAV
I
V
M
D
F
VLGFG
S
HE
DP
V
G
S
T
I
E
A
IK
E
A
K
A
I
A
AA
E
G
R
E
L
II
L
A
Y
V
L
GT
D
L
D
TP
S
LE
QQ
S
QM
L
L
DAGVI
L
ASS
STN
T
G
LLA
REF
ICKGEEA
fig|585395.4.peg.310
Escherichia coli O103:H2 str. 12009
MSVKIVIK
P
N
T
Y
F
DSVSLM
S
IS
T
R
A
N
KL
D
GV
E
QA
F
V
A
M
A
T
E
M
NK
GV
L
KNL
GL
LTPELE
Q
A
K
NG
DL
M
I
V
I
N
G
K
AGAD
NE
Q
L
LV
E
I
EE
L
FN
T
K
A
Q
----
SG
SH
E
A
R
YA
T
----
IA
SA
K
K
HI
PE
S
NLA
V
ISV
N
G
L
F
AA
R
EA
R
QAL
QND
LNVM
L
FSDNVS
V
EDE
LA
LK
Q
LA
H
EKGLL
M
MGPDCGTAIING
A
A
L
C
F
G
N
A
V
R
RGNIG
IV
GASGTG
S
QEL
SV
RI
HEF
G
G
G
V
SQ
L
IGTGGRDLSE
K
IGG
LM
ML
D
A
I
G
ML
EN
D
P
Q
TE
I
I
V
LISKPPAPAVARK
V
LERA
R
AC
R
KPVV
V
C
FLG
RG
E
TPVDEQ
G
L
Q
FA
RGSK
EAA
LK
AV
M
L
---
SGVKQEHLDLHTLNQ
P
LIA
DV
RA
RL
QPQQKY
IRGLF
C
GGTLC
D
E
T
MF
A
V
MEKH
G
-D
V
Y
SN
IQP
D
PEFR
L
QD
I
NR
S
IK
HT
F
LD
F
GDDDFT
N
GKPHPMIDPT
N
R
I
S
RL
I
E
E
AR
DP
E
VAV
I
V
M
D
F
VLGFG
S
HE
DP
V
G
S
T
I
E
A
IK
E
A
K
A
I
A
AA
E
G
R
E
L
II
L
A
Y
V
L
GT
D
L
D
TP
S
LE
QQ
S
QM
L
L
DAGVI
L
ASS
STN
T
G
LLA
REF
ICKGEEA
fig|409438.11.peg.463
Escherichia coli SE11
MSVKIVIK
P
N
T
Y
F
DSVSLM
S
IS
T
R
A
N
KL
D
GV
E
QA
F
V
A
M
A
T
E
M
NK
GV
L
KNL
GL
LTPELE
Q
A
K
NG
DL
M
I
V
I
N
G
K
AGAD
NE
Q
L
LV
E
I
EE
L
FN
T
K
A
Q
----
SG
SH
E
A
R
YA
T
----
IA
SA
K
K
HI
PE
S
NLA
V
ISV
N
G
L
F
AA
R
EA
R
QAL
QND
LNVM
L
FSDNVS
V
EDE
LA
LK
Q
LA
H
EKGLL
M
MGPDCGTAIING
A
A
L
C
F
G
N
A
V
R
RGNIG
IV
GASGTG
S
QEL
SV
RI
HEF
G
G
G
V
SQ
L
IGTGGRDLSE
K
IGG
LM
ML
D
A
I
G
ML
EN
D
P
Q
TE
I
I
V
LISKPPAPAVARK
V
LERA
R
AC
R
KPVV
V
C
FLG
RG
E
TPVDEQ
G
L
Q
FA
RGSK
EAA
LK
AV
M
L
---
SGVKQEHLDLHTLNQ
P
LIA
DV
RA
RL
QPQQKY
IRGLF
C
GGTLC
D
E
T
MF
A
V
MEKH
G
-D
V
Y
SN
IQP
D
PEFR
L
QD
I
NR
S
IK
HT
F
LD
F
GDDDFT
N
GKPHPMIDPT
N
R
I
S
RL
I
E
E
AR
DP
E
VAV
I
V
M
D
F
VLGFG
S
HE
DP
V
G
S
T
I
E
A
IK
E
A
K
A
I
A
AA
E
G
R
E
L
II
L
A
Y
V
L
GT
D
L
D
TP
S
LE
QQ
S
QM
L
L
DAGVI
L
ASS
STN
T
G
LLA
REF
ICKGEEA
fig|566546.3.peg.2475
Escherichia coli W
MSVKIVIK
P
N
T
Y
F
DSVSLM
S
IS
T
R
A
N
KL
D
GV
E
QA
F
V
A
M
A
T
E
M
NK
GV
L
KNL
GL
LTPELE
Q
A
K
NG
DL
M
I
V
I
N
G
K
AGAD
NE
Q
L
LV
E
I
EE
L
FN
T
K
A
Q
----
SG
SH
E
A
R
YA
T
----
IA
SA
K
K
HI
PE
S
NLA
V
ISV
N
G
L
F
AA
R
EA
R
QAL
QND
LNVM
L
FSDNVS
V
EDE
LA
LK
Q
LA
H
EKGLL
M
MGPDCGTAIING
A
A
L
C
F
G
N
A
V
R
RGNIG
IV
GASGTG
S
QEL
SV
RI
HEF
G
G
G
V
SQ
L
IGTGGRDLSE
K
IGG
LM
ML
D
A
I
G
ML
EN
D
P
Q
TE
I
I
V
LISKPPAPAVARK
V
LERA
R
AC
R
KPVV
V
C
FLG
RG
E
TPVDEQ
G
L
Q
FA
RGSK
EAA
LK
AV
M
L
---
SGVKQEHLDLHTLNQ
P
LIA
DV
RA
RL
QPQQKY
IRGLF
C
GGTLC
D
E
T
MF
A
V
MEKH
G
-D
V
Y
SN
IQP
D
PEFR
L
QD
I
NR
S
IK
HT
F
LD
F
GDDDFT
N
GKPHPMIDPT
N
R
I
S
RL
I
E
E
AR
DP
E
VAV
I
V
M
D
F
VLGFG
S
HE
DP
V
G
S
T
I
E
A
IK
E
A
K
A
I
A
AA
E
G
R
E
L
II
L
A
Y
V
L
GT
D
L
D
TP
S
LE
QQ
S
QM
L
L
DAGVI
L
ASS
STN
T
G
LLA
REF
ICKGEEA
fig|566546.4.peg.393
Escherichia coli W
MSVKIVIK
P
N
T
Y
F
DSVSLM
S
IS
T
R
A
N
KL
D
GV
E
QA
F
V
A
M
A
T
E
M
NK
GV
L
KNL
GL
LTPELE
Q
A
K
NG
DL
M
I
V
I
N
G
K
AGAD
NE
Q
L
LV
E
I
EE
L
FN
T
K
A
Q
----
SG
SH
E
A
R
YA
T
----
IA
SA
K
K
HI
PE
S
NLA
V
ISV
N
G
L
F
AA
R
EA
R
QAL
QND
LNVM
L
FSDNVS
V
EDE
LA
LK
Q
LA
H
EKGLL
M
MGPDCGTAIING
A
A
L
C
F
G
N
A
V
R
RGNIG
IV
GASGTG
S
QEL
SV
RI
HEF
G
G
G
V
SQ
L
IGTGGRDLSE
K
IGG
LM
ML
D
A
I
G
ML
EN
D
P
Q
TE
I
I
V
LISKPPAPAVARK
V
LERA
R
AC
R
KPVV
V
C
FLG
RG
E
TPVDEQ
G
L
Q
FA
RGSK
EAA
LK
AV
M
L
---
SGVKQEHLDLHTLNQ
P
LIA
DV
RA
RL
QPQQKY
IRGLF
C
GGTLC
D
E
T
MF
A
V
MEKH
G
-D
V
Y
SN
IQP
D
PEFR
L
QD
I
NR
S
IK
HT
F
LD
F
GDDDFT
N
GKPHPMIDPT
N
R
I
S
RL
I
E
E
AR
DP
E
VAV
I
V
M
D
F
VLGFG
S
HE
DP
V
G
S
T
I
E
A
IK
E
A
K
A
I
A
AA
E
G
R
E
L
II
L
A
Y
V
L
GT
D
L
D
TP
S
LE
QQ
S
QM
L
L
DAGVI
L
ASS
STN
T
G
LLA
REF
ICKGEEA
fig|550676.3.peg.1109
Escherichia coli B185
MSVKIVIK
P
N
T
Y
F
DSVSLM
S
IS
T
R
A
N
KL
D
GV
E
QA
F
V
A
M
A
T
E
M
NK
GV
L
KNL
GL
LTPELE
Q
A
K
NG
DL
M
I
V
I
N
G
K
SGAD
NE
Q
L
LV
E
I
EE
L
FN
T
K
A
Q
----
SG
SH
E
A
R
YA
T
----
IA
SA
K
K
HI
PE
S
NLA
V
ISV
N
G
L
F
AA
R
EA
R
QAL
QND
LNVM
L
FSDNVS
V
EDE
LA
LK
Q
LA
H
EKGLL
M
MGPDCGTAIING
A
A
L
C
F
G
N
A
V
R
RGNIG
IV
GASGTG
S
QEL
SV
RI
HEF
G
G
G
V
SQ
L
IGTGGRDLSE
K
IGG
LM
ML
D
A
I
G
ML
EN
D
P
Q
TE
I
IALISKPPAPAVARK
V
LERA
R
AC
R
KPVV
V
C
FLG
RG
E
TPVDEQ
G
L
Q
FA
RGTK
EAA
LK
AV
M
L
---
SGVKQENLDLHTLNQ
P
LIA
DV
RA
RL
QPQQKY
IRGLF
C
GGTLC
D
E
T
MF
A
V
MEKH
G
-D
V
Y
SN
IQP
D
PEFR
L
KD
I
NR
S
IK
HT
F
LD
F
GDDDFT
N
GKPHPMIDPT
N
R
I
S
RL
I
E
E
AR
DP
E
VAV
I
V
M
D
F
VLGFG
S
HE
DP
V
G
S
T
I
E
A
IK
E
A
K
A
I
A
AA
E
G
R
E
L
II
L
A
Y
V
L
GT
D
L
D
TP
S
LE
QQ
S
QM
L
L
DAGVI
L
ASS
STN
T
G
LLA
REF
ICKGEEA
fig|550677.3.peg.749
Escherichia coli B354
MSVKIVIK
P
N
T
Y
F
DSVSLM
S
IS
T
R
A
N
KL
D
GV
E
QA
F
V
A
M
A
T
E
M
NK
GV
L
KNL
GL
LTPELE
Q
A
K
NG
DL
M
I
V
I
N
G
K
AGAD
NE
Q
L
LV
E
I
EE
L
FN
S
K
A
Q
----
SG
SH
E
A
R
YA
T
----
IA
SA
K
K
HI
PE
S
NLA
V
ISV
N
G
L
F
AA
R
EA
R
QAL
QND
LNVM
L
FSDNVS
V
EDE
LA
LK
Q
LA
H
EKGLL
M
MGPDCGTAIING
A
A
L
C
F
G
N
A
V
R
RGNIG
IV
GASGTG
S
QEL
SV
RI
HEF
G
G
G
V
SQ
L
IGTGGRDLSE
K
IGG
LM
ML
D
A
I
G
ML
EN
D
P
Q
TE
I
I
V
LISKPPAPAVARK
V
LERA
R
AC
R
KPVV
V
C
FLG
RG
E
TPVDEQ
G
L
Q
FA
RGTK
EAA
LK
AV
M
L
---
SGVKQEHLDLHTLNQ
P
LIA
DV
RA
RL
QPQQKY
IRGLF
C
GGTLC
D
E
T
MF
A
V
MEKH
G
-D
V
Y
SN
IQP
D
PEFR
L
QD
V
NR
S
IK
HT
F
LD
F
GDDDFT
N
GKPHPMIDPT
N
R
I
S
RL
I
E
E
AR
DP
E
VAV
I
V
M
D
F
VLGFG
S
HE
DP
V
G
S
T
I
E
A
IK
E
A
K
A
I
A
AA
E
G
R
E
L
II
L
A
Y
V
L
GT
D
L
D
TP
S
LE
QQ
S
QM
L
L
DAGVI
L
ASS
STN
T
G
LLA
REF
ICKGEEA
fig|656437.3.peg.393
Escherichia coli TA143
MSVKIVIK
P
N
T
Y
F
DSVSLM
S
IS
T
R
A
N
KL
D
GV
E
QA
F
V
A
M
A
T
E
M
NK
GV
L
KNL
GL
LTPELE
Q
A
K
NG
DL
M
I
V
I
N
G
K
AGAD
NE
Q
L
LV
E
I
EE
L
FN
T
K
A
Q
----
SG
SH
E
A
R
YA
T
----
IA
SA
K
K
HI
PE
S
NLA
V
ISV
N
G
L
F
AA
R
EA
R
QAL
QND
LNVM
L
FSDNVS
V
EDE
LA
LK
Q
LA
H
EKGLL
M
MGPDCGTAIING
A
A
L
C
F
G
N
A
V
R
RGNIG
IV
GASGTG
S
QEL
SV
RI
HEF
G
G
G
V
SQ
L
IGTGGRDLSE
K
IGG
LM
ML
D
A
I
G
ML
EN
D
P
Q
TE
I
I
V
LISKPPAPAVARK
V
LERA
R
AC
R
KPVV
V
C
FLG
RG
E
TPVDEQ
G
L
Q
FA
RGTK
EAA
LK
AV
M
L
---
SGVKQEHLDLHTLNQ
P
LIA
DV
RA
RL
QPQQKY
IRGLF
C
GGTLC
D
E
T
MF
A
V
MEKH
G
-D
V
Y
SN
IQP
D
PEFR
L
QD
I
NR
S
IK
HT
F
LD
F
GDDDFT
N
GKPHPMIDPT
N
R
I
S
RL
I
E
E
AR
DP
E
VAV
I
V
M
D
F
VLGFG
S
HE
DP
V
G
S
T
I
E
A
IK
E
A
K
A
I
A
AA
E
G
R
E
L
II
L
A
Y
V
L
GT
D
L
D
TP
S
LE
QQ
S
QM
L
L
DAGVI
L
ASS
STN
T
G
LLA
REF
ICKGEEA
fig|656393.3.peg.962
Escherichia coli H299
MSVKIVIK
P
N
T
Y
F
DSVSLM
S
IS
T
R
A
N
KL
D
GV
E
QA
F
V
A
M
A
T
E
M
NK
GV
L
KNL
GL
LTPELE
Q
A
K
NG
DL
M
I
V
I
N
G
K
AGAD
NE
Q
L
LV
E
I
EE
L
FN
T
K
A
Q
----
SG
SH
E
A
R
YA
T
----
IA
SA
K
K
HI
PE
S
NLA
V
ISV
N
G
L
F
AA
R
EA
R
QAL
QND
LNVM
L
FSDNV
T
V
EDE
LA
LK
Q
LA
H
EKGLL
M
MGPDCGTAIING
A
A
L
C
F
G
N
A
V
R
RGNIG
IV
GASGTG
S
QEL
SV
RI
HEF
G
G
G
V
SQ
L
IGTGGRDLSE
K
IGG
LM
ML
D
A
I
G
ML
EN
D
P
Q
TE
I
I
V
LISKPPAPAVARK
V
LERA
R
AC
R
KPVV
V
C
FLG
RG
E
TPVDEQ
G
L
Q
FA
RGSK
EAA
LK
AV
M
L
---
SGMKQEHLDLHTLNQ
P
LIA
DV
RA
RL
QPQQKY
IRGLF
C
GGTLC
D
E
T
MF
A
V
MEKH
G
-D
V
Y
SN
IQP
D
PEFR
L
QD
I
NR
S
VK
HT
F
LD
F
GDDDFT
N
GKPHPMIDPT
N
R
I
S
RL
I
E
E
AR
DP
E
VAV
I
V
M
D
F
VLGFG
S
HE
DP
V
G
S
T
I
E
A
IK
E
A
K
A
I
A
AA
E
G
R
E
L
II
L
A
Y
V
L
GT
D
L
D
TP
S
LE
QQ
S
QM
L
L
DAGVI
L
ASS
STN
T
G
LLA
REF
ICKGEEA
fig|749527.3.peg.2544
Escherichia coli MS 21-1
MSVKIVIK
P
N
T
Y
F
DSVSLM
S
IS
T
R
A
N
KL
D
GV
E
QA
F
V
A
M
A
T
E
M
NK
GV
L
KNL
GL
LTPELE
Q
A
K
NG
DL
M
I
V
I
N
G
K
AGAD
NE
Q
L
LV
E
I
EE
L
FN
S
K
A
Q
----
SG
SH
E
A
R
YA
T
----
IA
SA
K
K
HI
PE
S
NLA
V
ISV
N
G
L
F
AA
R
EA
R
QAL
QND
LNVM
L
FSDNVS
V
EDE
LA
LK
Q
LA
H
EKGLL
L
MGPDCGTAIING
A
A
L
C
F
G
N
A
V
R
RGNIG
IV
GASGTG
S
QEL
SV
RI
HEF
G
G
G
V
SQ
L
IGTGGRDLSE
K
IGG
LM
ML
D
A
I
G
ML
EN
D
P
Q
TE
I
I
V
LISKPPAPAVARK
V
LERA
R
AC
R
KPVV
V
C
FLG
RG
E
TPVDEQ
G
L
Q
FA
RGSK
EAA
LK
AV
M
L
---
SGVKQEHLDLHTLNQ
P
LIA
DV
RA
RL
KPQQKY
IRGLF
C
GGTLC
D
E
T
MF
A
V
MEKH
G
-D
V
Y
SN
IQP
D
PEFR
L
KD
I
NR
S
VK
HT
F
LD
F
GDDDFT
N
GKPHPMIDPT
N
R
I
S
RL
I
E
E
AR
DP
E
VAV
I
V
M
D
F
VLGFG
S
HE
DP
V
G
S
T
I
E
A
IK
E
A
K
A
I
A
AA
E
G
R
E
L
II
L
A
Y
V
L
GT
D
L
D
TP
S
LE
QQ
S
QM
L
L
DAGVI
L
ASS
STN
T
G
LLA
REF
ICKGEEA
fig|216592.1.peg.4906
Escherichia coli 042
MSVKIVIK
P
N
T
Y
F
DSVSLM
S
IS
T
R
A
N
KL
D
GV
E
QA
F
V
A
M
A
T
E
M
NK
GV
L
KNL
GL
LTPELE
Q
A
K
NG
DL
M
I
V
I
N
G
K
AGAD
NE
Q
L
LV
E
I
EE
L
FN
T
K
A
Q
----
SG
SH
E
A
R
YA
T
----
IA
SA
K
K
HI
PE
S
NLA
V
ISV
N
G
L
F
AA
R
EA
R
QAL
QND
LNVM
L
FSDNVS
V
EDE
LA
LK
Q
LA
H
EKGLL
M
MGPDCGTAIING
A
A
L
C
F
G
N
A
V
R
RGNIG
IV
GASGTG
S
QEL
SV
RI
HEF
G
G
G
V
SQ
L
IGTGGRDLSE
K
IGG
LM
ML
D
A
I
G
ML
EN
D
P
Q
TE
I
I
V
LISKPPAPAVARK
V
LERA
R
AC
R
KPVV
V
C
FLG
RG
E
TPVDEQ
G
L
Q
FA
RGSK
EAA
LK
AV
M
L
---
SGVKQEHLELHTLNQ
S
LIA
DV
RA
RL
QPQQKY
IRGLF
C
GGTLC
D
E
T
MF
A
V
MEKH
G
-D
V
Y
SN
IQP
D
PEFR
L
QD
I
NR
S
IK
HT
F
LD
F
GDDDFT
N
GKPHPMIDPT
N
R
I
S
RL
I
E
E
AR
DP
E
VAV
I
V
M
D
F
VLGFG
S
HE
DP
V
G
S
T
I
E
A
IK
E
A
K
A
I
A
AA
E
G
R
E
L
II
L
A
Y
V
L
GT
D
L
D
TP
S
LE
QQ
S
QM
L
L
DAGVI
L
ASS
STN
T
G
LLA
REF
ICKGEEA
fig|216592.3.peg.376
Escherichia coli 042
MSVKIVIK
P
N
T
Y
F
DSVSLM
S
IS
T
R
A
N
KL
D
GV
E
QA
F
V
A
M
A
T
E
M
NK
GV
L
KNL
GL
LTPELE
Q
A
K
NG
DL
M
I
V
I
N
G
K
AGAD
NE
Q
L
LV
E
I
EE
L
FN
T
K
A
Q
----
SG
SH
E
A
R
YA
T
----
IA
SA
K
K
HI
PE
S
NLA
V
ISV
N
G
L
F
AA
R
EA
R
QAL
QND
LNVM
L
FSDNVS
V
EDE
LA
LK
Q
LA
H
EKGLL
M
MGPDCGTAIING
A
A
L
C
F
G
N
A
V
R
RGNIG
IV
GASGTG
S
QEL
SV
RI
HEF
G
G
G
V
SQ
L
IGTGGRDLSE
K
IGG
LM
ML
D
A
I
G
ML
EN
D
P
Q
TE
I
I
V
LISKPPAPAVARK
V
LERA
R
AC
R
KPVV
V
C
FLG
RG
E
TPVDEQ
G
L
Q
FA
RGSK
EAA
LK
AV
M
L
---
SGVKQEHLELHTLNQ
S
LIA
DV
RA
RL
QPQQKY
IRGLF
C
GGTLC
D
E
T
MF
A
V
MEKH
G
-D
V
Y
SN
IQP
D
PEFR
L
QD
I
NR
S
IK
HT
F
LD
F
GDDDFT
N
GKPHPMIDPT
N
R
I
S
RL
I
E
E
AR
DP
E
VAV
I
V
M
D
F
VLGFG
S
HE
DP
V
G
S
T
I
E
A
IK
E
A
K
A
I
A
AA
E
G
R
E
L
II
L
A
Y
V
L
GT
D
L
D
TP
S
LE
QQ
S
QM
L
L
DAGVI
L
ASS
STN
T
G
LLA
REF
ICKGEEA
fig|701177.3.peg.415
Escherichia coli O55:H7 str. CB9615
MSVKIVIK
P
N
T
Y
F
DSVSLM
S
IS
T
R
A
N
KL
D
GV
E
QA
F
V
A
M
A
T
E
M
NK
GV
L
KNL
GL
LTPELE
Q
A
K
NG
DL
M
I
V
I
N
G
K
SGAD
NE
Q
L
LV
E
I
EE
L
FN
T
K
A
Q
----
SG
SH
E
A
R
YA
T
----
IA
SA
K
K
HI
PE
S
NLA
V
ISV
N
G
L
F
AA
R
EA
R
QAL
QND
LNVM
L
FSDNVS
V
EDE
LA
LK
Q
LA
H
EKGLL
M
MGPDCGTAIING
A
A
L
C
F
G
N
A
V
R
RGNIG
IV
GASGTG
S
QEL
SV
RI
HEF
G
G
G
V
SQ
L
IGTGGRDLSE
K
IGG
LM
ML
D
A
I
G
ML
EN
D
P
Q
TE
I
IALISKPPAPAVARK
V
LERA
R
AC
R
KPVV
V
C
FLG
RG
E
TPVDEQ
G
L
Q
FA
RGTK
EAA
LK
AV
M
L
---
SGVKQEHLDLHTLNQ
P
LIA
DV
RA
RL
KPQQKY
IRGLF
C
GGTLC
D
E
T
MF
A
V
MEKH
S
-D
V
Y
SN
IQP
D
PEFR
L
KD
I
NR
S
IK
HT
F
LD
F
GDDDFT
N
GKPHPMIDPT
N
R
I
S
RL
I
E
E
AR
DP
E
VAV
I
V
M
D
F
VLGFG
S
HE
DP
V
G
S
T
I
E
A
IK
E
A
K
A
I
A
AA
E
G
R
E
L
II
L
A
Y
V
L
GT
D
L
D
TP
S
LE
QQ
S
QM
L
L
DAGVI
L
ASS
STN
T
G
LLA
REF
ICKGEEA
fig|656419.3.peg.507
Escherichia coli M718
MSVKIVIK
P
N
T
Y
F
DSVSLM
S
IS
T
S
A
N
KL
D
GV
E
QA
F
V
A
M
A
T
E
M
NK
GV
L
KNL
GL
LTPELE
Q
A
K
NG
DL
M
I
V
I
N
G
K
SGAD
NE
Q
L
LV
E
I
EE
L
FN
S
K
A
Q
----
SG
SH
E
A
R
YA
T
----
IA
SA
K
K
HI
PE
S
NLA
V
ISV
N
G
L
F
AA
R
EA
R
QAL
QND
LNVM
L
FSDNVS
V
EDE
LA
LK
Q
LA
H
EKGLL
M
MGPDCGTAIING
A
A
L
C
F
G
N
A
V
H
RGNIG
IV
GASGTG
S
QEL
SV
RI
HEF
G
G
G
V
SQ
L
IGTGGRDLSE
K
IGG
LM
ML
D
A
I
G
ML
EN
D
P
Q
TE
I
IALISKPPAPAVARK
V
LERA
R
AC
R
KPVV
V
C
FLG
RG
E
TPVDEQ
G
L
Q
FA
RGSK
EAA
LK
AV
M
L
---
SGVKQENLDLHTLNQ
P
LIA
DV
RA
RL
QPQQKY
IRGLF
C
GGTLC
D
E
T
MF
A
V
MEKH
S
-D
V
Y
SN
IQP
D
PEFR
L
KD
I
NR
S
IK
HT
F
LD
F
GDDDFT
N
GKPHPMIDPT
N
R
I
S
RL
L
E
E
AR
DP
E
VAV
I
V
M
D
F
VLGFG
S
HE
DP
V
G
S
T
I
E
A
IK
E
A
K
A
I
A
AA
E
G
R
E
L
II
L
A
Y
V
L
GT
D
L
D
TP
S
LE
QQ
S
QM
L
L
DAGVI
L
ASS
STN
T
G
LLA
REF
ICKGEEA
fig|656379.3.peg.1188
Escherichia coli FVEC1302
MSVKIVIK
P
N
T
Y
F
DSVSLM
S
IS
T
R
A
N
KL
D
GV
E
QA
F
V
A
M
A
T
E
M
NK
GV
L
KNL
GL
LTPELE
Q
A
K
NG
DL
M
I
V
I
N
G
K
SGVD
NE
Q
L
LA
E
I
EE
L
FN
T
K
A
Q
----
SG
SH
E
A
R
YA
T
----
IA
SA
K
K
HI
PE
S
NLA
V
ISV
N
G
L
F
AA
R
EA
R
QAL
QND
LNVM
L
FSDNVS
V
EDE
LA
LK
Q
LA
H
EKGLL
M
MGPDCGTAIING
A
A
L
C
F
G
N
A
V
R
RGNIG
IV
GASGTG
S
QEL
SV
RI
HEF
G
G
G
V
SQ
L
IGTGGRDLSE
K
IGG
LM
ML
D
A
I
G
ML
EN
D
P
Q
TE
I
I
V
LISKPPAPAVARK
V
LERA
R
AC
R
KPVV
V
C
FLG
RG
E
TPVDEQ
G
L
Q
FA
RGSK
EAA
LK
AV
M
L
---
SGVKQEHLDLHTLNQ
P
LIA
DV
RA
RL
QPQQKY
IRGLF
C
GGTLC
D
E
T
MF
A
V
MEKH
G
-D
V
Y
SN
IQP
D
PEFR
L
QD
I
SR
S
IK
HT
F
LD
F
GDDDFT
N
GKPHPMIDPT
N
R
I
S
RL
I
E
E
AR
DP
E
VAV
I
V
M
D
F
VLGFG
S
HE
DP
V
G
S
T
I
E
A
IK
E
A
K
A
I
A
AA
E
G
R
E
L
II
L
A
Y
V
L
GT
D
L
D
TP
S
LE
QQ
S
QM
L
L
DAGVI
L
ASS
STN
T
G
LLA
REF
ICKGEEA
fig|656380.3.peg.945
Escherichia coli FVEC1412
MSVKIVIK
P
N
T
Y
F
DSVSLM
S
IS
T
R
A
N
KL
D
GV
E
QA
F
V
A
M
A
T
E
M
NK
GV
L
KNL
GL
LTPELE
Q
A
K
NG
DL
M
I
V
I
N
G
K
SGVD
NE
Q
L
LA
E
I
EE
L
FN
T
K
A
Q
----
SG
SH
E
A
R
YA
T
----
IA
SA
K
K
HI
PE
S
NLA
V
ISV
N
G
L
F
AA
R
EA
R
QAL
QND
LNVM
L
FSDNVS
V
EDE
LA
LK
Q
LA
H
EKGLL
M
MGPDCGTAIING
A
A
L
C
F
G
N
A
V
R
RGNIG
IV
GASGTG
S
QEL
SV
RI
HEF
G
G
G
V
SQ
L
IGTGGRDLSE
K
IGG
LM
ML
D
A
I
G
ML
EN
D
P
Q
TE
I
I
V
LISKPPAPAVARK
V
LERA
R
AC
R
KPVV
V
C
FLG
RG
E
TPVDEQ
G
L
Q
FA
RGSK
EAA
LK
AV
M
L
---
SGVKQEHLDLHTLNQ
P
LIA
DV
RA
RL
QPQQKY
IRGLF
C
GGTLC
D
E
T
MF
A
V
MEKH
G
-D
V
Y
SN
IQP
D
PEFR
L
QD
I
SR
S
IK
HT
F
LD
F
GDDDFT
N
GKPHPMIDPT
N
R
I
S
RL
I
E
E
AR
DP
E
VAV
I
V
M
D
F
VLGFG
S
HE
DP
V
G
S
T
I
E
A
IK
E
A
K
A
I
A
AA
E
G
R
E
L
II
L
A
Y
V
L
GT
D
L
D
TP
S
LE
QQ
S
QM
L
L
DAGVI
L
ASS
STN
T
G
LLA
REF
ICKGEEA
fig|749549.3.peg.617
Escherichia coli MS 198-1
MSVKIVIK
P
N
T
Y
F
DSVSLM
S
IS
T
R
A
N
KL
D
GV
E
QA
F
V
A
M
A
T
E
M
NK
GV
L
KNL
GL
LTPELE
Q
A
K
NG
DL
M
I
V
I
N
G
K
SGVD
NE
Q
L
LA
E
I
EE
L
FN
T
K
A
Q
----
SG
SH
E
A
R
YA
T
----
IA
SA
K
K
HI
PE
S
NLA
V
ISV
N
G
L
F
AA
R
EA
R
QAL
QND
LNVM
L
FSDNVS
V
EDE
LA
LK
Q
LA
H
EKGLL
M
MGPDCGTAIING
A
A
L
C
F
G
N
A
V
R
RGNIG
IV
GASGTG
S
QEL
SV
RI
HEF
G
G
G
V
SQ
L
IGTGGRDLSE
K
IGG
LM
ML
D
A
I
G
ML
EN
D
P
Q
TE
I
I
V
LISKPPAPAVARK
V
LERA
R
AC
R
KPVV
V
C
FLG
RG
E
TPVDEQ
G
L
Q
FA
RGSK
EAA
LK
AV
M
L
---
SGVKQEHLDLHTLNQ
P
LIA
DV
RA
RL
QPQQKY
IRGLF
C
GGTLC
D
E
T
MF
A
V
MEKH
G
-D
V
Y
SN
IQP
D
PEFR
L
QD
I
SR
S
IK
HT
F
LD
F
GDDDFT
N
GKPHPMIDPT
N
R
I
S
RL
I
E
E
AR
DP
E
VAV
I
V
M
D
F
VLGFG
S
HE
DP
V
G
S
T
I
E
A
IK
E
A
K
A
I
A
AA
E
G
R
E
L
II
L
A
Y
V
L
GT
D
L
D
TP
S
LE
QQ
S
QM
L
L
DAGVI
L
ASS
STN
T
G
LLA
REF
ICKGEEA
fig|585056.7.peg.557
Escherichia coli UMN026
MSVKIVIK
P
N
T
Y
F
DSVSLM
S
IS
T
R
A
N
KL
D
GV
E
QA
F
V
A
M
A
T
E
M
NK
GV
L
KNL
GL
LTPELE
Q
A
K
NG
DL
M
I
V
I
N
G
K
SGVD
NE
Q
L
LA
E
I
EE
L
FN
T
K
A
Q
----
SG
SH
E
A
R
YA
T
----
IA
SA
K
K
HI
PE
S
NLA
V
ISV
N
G
L
F
AA
R
EA
R
QAL
QND
LNVM
L
FSDNVS
V
EDE
LA
LK
Q
LA
H
EKGLL
M
MGPDCGTAIING
A
A
L
C
F
G
N
A
V
R
RGNIG
IV
GASGTG
S
QEL
SV
RI
HEF
G
G
G
V
SQ
L
IGTGGRDLSE
K
IGG
LM
ML
D
A
I
G
ML
EN
D
P
Q
TE
I
I
V
LISKPPAPAVARK
V
LERA
R
AC
R
KPVV
V
C
FLG
RG
E
TPVDEQ
G
L
Q
FA
RGSK
EAA
LK
AV
M
L
---
SGVKQEHLDLHTLNQ
P
LIA
DV
RA
RL
QPQQKY
IRGLF
C
GGTLC
D
E
T
MF
A
V
MEKH
G
-D
V
Y
SN
IQP
D
PEFR
L
QD
I
SR
S
IK
HT
F
LD
F
GDDDFT
N
GKPHPMIDPT
N
R
I
S
RL
I
E
E
AR
DP
E
VAV
I
V
M
D
F
VLGFG
S
HE
DP
V
G
S
T
I
E
A
IK
E
A
K
A
I
A
AA
E
G
R
E
L
II
L
A
Y
V
L
GT
D
L
D
TP
S
LE
QQ
S
QM
L
L
DAGVI
L
ASS
STN
T
G
LLA
REF
ICKGEEA
fig|585057.4.peg.393
Escherichia coli IAI39
MSVKIVIK
P
N
T
Y
F
DSVSLM
S
IS
T
R
A
N
KL
D
GV
E
QA
F
V
A
M
A
T
E
M
NK
GV
L
KNL
GL
LTPELE
Q
A
K
NG
DL
M
I
V
I
N
G
K
AGAD
NE
Q
L
LV
E
I
EE
L
FN
T
K
A
Q
----
T
G
SH
E
A
R
YA
T
----
IA
SA
K
K
HI
PE
S
NLA
V
ISV
N
G
L
F
AA
R
EA
R
QAL
QND
LNVM
L
FSDNVS
V
EDE
LA
LK
Q
LA
H
EKGLL
M
MGPDCGTAIING
A
A
L
C
F
G
N
A
V
R
RGNIG
IV
GASGTG
S
QEL
SV
RI
HEF
C
G
G
V
SQ
L
IGTGGRDLSE
K
IGG
LM
ML
D
A
I
G
ML
EN
D
P
Q
TE
I
I
V
LISKPPAPAVARK
V
LERA
R
AC
R
KPVV
V
C
FLG
RG
E
TPVDEQ
G
L
Q
FA
RGSK
EAA
LK
AV
M
L
---
SGVKQEHLDLHTLNQ
P
LIA
DV
RA
RL
KPQQKY
IRGLF
C
GGTLC
D
E
T
MF
A
V
MEKH
G
-D
V
Y
SN
IQP
D
PEFR
L
KD
I
NR
S
VK
HT
F
LD
F
GDDDFT
N
GKPHPMIDPT
N
R
I
S
RL
I
E
E
AR
DP
E
VAV
I
V
M
D
F
VLGFG
S
HE
DP
V
G
S
T
I
E
A
IK
E
A
K
A
I
A
AA
D
G
R
E
L
II
L
A
Y
V
L
GT
D
L
D
TP
S
LE
QQ
S
QM
L
L
DAGVI
L
ASS
STN
T
G
LLA
REF
ICKGEEA
fig|585057.6.peg.392
Escherichia coli IAI39
MSVKIVIK
P
N
T
Y
F
DSVSLM
S
IS
T
R
A
N
KL
D
GV
E
QA
F
V
A
M
A
T
E
M
NK
GV
L
KNL
GL
LTPELE
Q
A
K
NG
DL
M
I
V
I
N
G
K
AGAD
NE
Q
L
LV
E
I
EE
L
FN
T
K
A
Q
----
T
G
SH
E
A
R
YA
T
----
IA
SA
K
K
HI
PE
S
NLA
V
ISV
N
G
L
F
AA
R
EA
R
QAL
QND
LNVM
L
FSDNVS
V
EDE
LA
LK
Q
LA
H
EKGLL
M
MGPDCGTAIING
A
A
L
C
F
G
N
A
V
R
RGNIG
IV
GASGTG
S
QEL
SV
RI
HEF
C
G
G
V
SQ
L
IGTGGRDLSE
K
IGG
LM
ML
D
A
I
G
ML
EN
D
P
Q
TE
I
I
V
LISKPPAPAVARK
V
LERA
R
AC
R
KPVV
V
C
FLG
RG
E
TPVDEQ
G
L
Q
FA
RGSK
EAA
LK
AV
M
L
---
SGVKQEHLDLHTLNQ
P
LIA
DV
RA
RL
KPQQKY
IRGLF
C
GGTLC
D
E
T
MF
A
V
MEKH
G
-D
V
Y
SN
IQP
D
PEFR
L
KD
I
NR
S
VK
HT
F
LD
F
GDDDFT
N
GKPHPMIDPT
N
R
I
S
RL
I
E
E
AR
DP
E
VAV
I
V
M
D
F
VLGFG
S
HE
DP
V
G
S
T
I
E
A
IK
E
A
K
A
I
A
AA
D
G
R
E
L
II
L
A
Y
V
L
GT
D
L
D
TP
S
LE
QQ
S
QM
L
L
DAGVI
L
ASS
STN
T
G
LLA
REF
ICKGEEA
fig|656444.3.peg.780
Escherichia coli TA280
MSVKIVIK
P
N
T
Y
F
DSVSLM
S
IS
T
R
A
N
KL
D
GV
E
QA
F
V
A
M
A
T
E
M
NK
GV
L
KNL
GL
LTPELE
Q
A
K
NG
DL
M
I
V
I
N
G
K
SGVD
NE
Q
L
LA
E
I
EE
L
FN
T
K
A
Q
----
SG
SH
E
A
R
YA
T
----
IA
SA
K
K
HI
PE
S
NLA
V
ISV
N
G
L
F
AA
R
EA
R
QAL
QND
LNVM
L
FSDNVS
V
EDE
LA
LK
Q
LA
H
EKGLL
L
MGPDCGTAIING
A
A
L
C
F
G
N
A
V
R
RGNIG
IV
GASGTG
S
QEL
SV
RI
HEF
G
G
G
V
SQ
L
IGTGGRDLSE
K
IGG
LM
ML
D
A
I
G
ML
EN
D
P
Q
TE
I
I
V
LISKPPAPAVARK
V
LERA
R
AC
R
KPVV
V
C
FLG
RG
E
TPVDEQ
G
L
Q
FA
RGSK
EAA
LK
AV
M
L
---
SGVKQEHLDLHTLNQ
P
LIA
DV
RV
RL
QPQQKY
IRGLF
C
GGTLC
D
E
T
MF
A
V
MEKH
G
-D
V
Y
SN
IQP
D
PEFR
L
QD
I
NR
S
IK
HT
F
LD
F
GDDDFT
N
GKPHPMIDPT
N
R
I
S
RL
I
E
E
AR
DP
E
VAV
I
V
M
D
F
VLGFG
S
HE
DP
V
G
S
T
I
E
A
IK
E
A
K
A
I
A
AA
E
G
R
E
L
II
L
A
Y
V
L
GT
D
L
D
TP
S
LE
QQ
S
QM
L
L
DAGVI
L
ASS
STN
T
G
LLA
REF
ICKGEEA
fig|562.371.peg.1215
Escherichia coli 1044A
MSVKIVIK
P
N
T
Y
F
DSVSLM
S
IS
T
R
A
N
KL
D
GV
E
QA
F
V
A
M
A
T
E
M
NK
GV
L
KNL
GL
LTPELE
Q
A
K
NG
DL
M
I
V
I
N
G
K
SGAD
NE
Q
L
LV
E
I
EE
L
FN
T
K
A
Q
----
SG
SH
E
A
R
YA
T
----
IA
SA
K
K
HI
PE
S
NLA
V
ISV
N
G
L
F
AA
R
EA
R
QAL
QND
LNVM
L
FSDNVS
V
EDE
LA
LK
Q
LA
H
EKGLL
M
MGPDCGTAIING
A
A
L
C
F
G
N
A
V
R
RGNIG
IV
GASGTG
S
QEL
SV
RI
HEF
G
G
G
V
SQ
L
IGTGGRDLSE
K
IGG
LM
ML
D
A
I
G
ML
EN
D
P
Q
TE
I
IALISKPPAPAVARK
V
LERA
R
AC
R
KPVV
V
C
FLG
RG
E
TPVDEQ
G
L
Q
FA
RGTK
EAA
LK
AV
M
L
---
SGVKQEHLDLHTLNQ
P
LIT
DV
RA
RL
KPQQKY
IRGLF
C
GGTLC
D
E
T
MF
A
V
MEKH
S
-D
V
Y
SN
IQP
D
PEFR
L
KD
I
NR
S
IK
HT
F
LD
F
GDDDFT
N
GKPHPMIDPT
N
R
I
S
RL
I
E
E
AR
DP
E
VAV
I
V
M
D
F
VLGFG
S
HE
DP
V
G
S
T
I
E
A
IK
E
A
K
A
I
A
AA
E
G
R
E
L
II
L
A
Y
V
L
GT
D
L
D
TP
S
LE
QQ
S
QM
L
L
DAGVI
L
ASS
STN
T
G
LLA
REF
ICKGEEA
fig|562.373.peg.490
Escherichia coli 1125A
MSVKIVIK
P
N
T
Y
F
DSVSLM
S
IS
T
R
A
N
KL
D
GV
E
QA
F
V
A
M
A
T
E
M
NK
GV
L
KNL
GL
LTPELE
Q
A
K
NG
DL
M
I
V
I
N
G
K
SGAD
NE
Q
L
LV
E
I
EE
L
FN
T
K
A
Q
----
SG
SH
E
A
R
YA
T
----
IA
SA
K
K
HI
PE
S
NLA
V
ISV
N
G
L
F
AA
R
EA
R
QAL
QND
LNVM
L
FSDNVS
V
EDE
LA
LK
Q
LA
H
EKGLL
M
MGPDCGTAIING
A
A
L
C
F
G
N
A
V
R
RGNIG
IV
GASGTG
S
QEL
SV
RI
HEF
G
G
G
V
SQ
L
IGTGGRDLSE
K
IGG
LM
ML
D
A
I
G
ML
EN
D
P
Q
TE
I
IALISKPPAPAVARK
V
LERA
R
AC
R
KPVV
V
C
FLG
RG
E
TPVDEQ
G
L
Q
FA
RGTK
EAA
LK
AV
M
L
---
SGVKQEHLDLHTLNQ
P
LIT
DV
RA
RL
KPQQKY
IRGLF
C
GGTLC
D
E
T
MF
A
V
MEKH
S
-D
V
Y
SN
IQP
D
PEFR
L
KD
I
NR
S
IK
HT
F
LD
F
GDDDFT
N
GKPHPMIDPT
N
R
I
S
RL
I
E
E
AR
DP
E
VAV
I
V
M
D
F
VLGFG
S
HE
DP
V
G
S
T
I
E
A
IK
E
A
K
A
I
A
AA
E
G
R
E
L
II
L
A
Y
V
L
GT
D
L
D
TP
S
LE
QQ
S
QM
L
L
DAGVI
L
ASS
STN
T
G
LLA
REF
ICKGEEA
fig|562.372.peg.667
Escherichia coli 1212A
MSVKIVIK
P
N
T
Y
F
DSVSLM
S
IS
T
R
A
N
KL
D
GV
E
QA
F
V
A
M
A
T
E
M
NK
GV
L
KNL
GL
LTPELE
Q
A
K
NG
DL
M
I
V
I
N
G
K
SGAD
NE
Q
L
LV
E
I
EE
L
FN
T
K
A
Q
----
SG
SH
E
A
R
YA
T
----
IA
SA
K
K
HI
PE
S
NLA
V
ISV
N
G
L
F
AA
R
EA
R
QAL
QND
LNVM
L
FSDNVS
V
EDE
LA
LK
Q
LA
H
EKGLL
M
MGPDCGTAIING
A
A
L
C
F
G
N
A
V
R
RGNIG
IV
GASGTG
S
QEL
SV
RI
HEF
G
G
G
V
SQ
L
IGTGGRDLSE
K
IGG
LM
ML
D
A
I
G
ML
EN
D
P
Q
TE
I
IALISKPPAPAVARK
V
LERA
R
AC
R
KPVV
V
C
FLG
RG
E
TPVDEQ
G
L
Q
FA
RGTK
EAA
LK
AV
M
L
---
SGVKQEHLDLHTLNQ
P
LIT
DV
RA
RL
KPQQKY
IRGLF
C
GGTLC
D
E
T
MF
A
V
MEKH
S
-D
V
Y
SN
IQP
D
PEFR
L
KD
I
NR
S
IK
HT
F
LD
F
GDDDFT
N
GKPHPMIDPT
N
R
I
S
RL
I
E
E
AR
DP
E
VAV
I
V
M
D
F
VLGFG
S
HE
DP
V
G
S
T
I
E
A
IK
E
A
K
A
I
A
AA
E
G
R
E
L
II
L
A
Y
V
L
GT
D
L
D
TP
S
LE
QQ
S
QM
L
L
DAGVI
L
ASS
STN
T
G
LLA
REF
ICKGEEA
fig|562.374.peg.1249
Escherichia coli 536A
MSVKIVIK
P
N
T
Y
F
DSVSLM
S
IS
T
R
A
N
KL
D
GV
E
QA
F
V
A
M
A
T
E
M
NK
GV
L
KNL
GL
LTPELE
Q
A
K
NG
DL
M
I
V
I
N
G
K
SGAD
NE
Q
L
LV
E
I
EE
L
FN
T
K
A
Q
----
SG
SH
E
A
R
YA
T
----
IA
SA
K
K
HI
PE
S
NLA
V
ISV
N
G
L
F
AA
R
EA
R
QAL
QND
LNVM
L
FSDNVS
V
EDE
LA
LK
Q
LA
H
EKGLL
M
MGPDCGTAIING
A
A
L
C
F
G
N
A
V
R
RGNIG
IV
GASGTG
S
QEL
SV
RI
HEF
G
G
G
V
SQ
L
IGTGGRDLSE
K
IGG
LM
ML
D
A
I
G
ML
EN
D
P
Q
TE
I
IALISKPPAPAVARK
V
LERA
R
AC
R
KPVV
V
C
FLG
RG
E
TPVDEQ
G
L
Q
FA
RGTK
EAA
LK
AV
M
L
---
SGVKQEHLDLHTLNQ
P
LIT
DV
RA
RL
KPQQKY
IRGLF
C
GGTLC
D
E
T
MF
A
V
MEKH
S
-D
V
Y
SN
IQP
D
PEFR
L
KD
I
NR
S
IK
HT
F
LD
F
GDDDFT
N
GKPHPMIDPT
N
R
I
S
RL
I
E
E
AR
DP
E
VAV
I
V
M
D
F
VLGFG
S
HE
DP
V
G
S
T
I
E
A
IK
E
A
K
A
I
A
AA
E
G
R
E
L
II
L
A
Y
V
L
GT
D
L
D
TP
S
LE
QQ
S
QM
L
L
DAGVI
L
ASS
STN
T
G
LLA
REF
ICKGEEA
fig|83334.1.peg.446
Escherichia coli O157:H7
MSVKIVIK
P
N
T
Y
F
DSVSLM
S
IS
T
R
A
N
KL
D
GV
E
QA
F
V
A
M
A
T
E
M
NK
GV
L
KNL
GL
LTPELE
Q
A
K
NG
DL
M
I
V
I
N
G
K
SGAD
NE
Q
L
LV
E
I
EE
L
FN
T
K
A
Q
----
SG
SH
E
A
R
YA
T
----
IA
SA
K
K
HI
PE
S
NLA
V
ISV
N
G
L
F
AA
R
EA
R
QAL
QND
LNVM
L
FSDNVS
V
EDE
LA
LK
Q
LA
H
EKGLL
M
MGPDCGTAIING
A
A
L
C
F
G
N
A
V
R
RGNIG
IV
GASGTG
S
QEL
SV
RI
HEF
G
G
G
V
SQ
L
IGTGGRDLSE
K
IGG
LM
ML
D
A
I
G
ML
EN
D
P
Q
TE
I
IALISKPPAPAVARK
V
LERA
R
AC
R
KPVV
V
C
FLG
RG
E
TPVDEQ
G
L
Q
FA
RGTK
EAA
LK
AV
M
L
---
SGVKQEHLDLHTLNQ
P
LIT
DV
RA
RL
KPQQKY
IRGLF
C
GGTLC
D
E
T
MF
A
V
MEKH
S
-D
V
Y
SN
IQP
D
PEFR
L
KD
I
NR
S
IK
HT
F
LD
F
GDDDFT
N
GKPHPMIDPT
N
R
I
S
RL
I
E
E
AR
DP
E
VAV
I
V
M
D
F
VLGFG
S
HE
DP
V
G
S
T
I
E
A
IK
E
A
K
A
I
A
AA
E
G
R
E
L
II
L
A
Y
V
L
GT
D
L
D
TP
S
LE
QQ
S
QM
L
L
DAGVI
L
ASS
STN
T
G
LLA
REF
ICKGEEA
fig|155864.1.peg.364
Escherichia coli O157:H7 EDL933
MSVKIVIK
P
N
T
Y
F
DSVSLM
S
IS
T
R
A
N
KL
D
GV
E
QA
F
V
A
M
A
T
E
M
NK
GV
L
KNL
GL
LTPELE
Q
A
K
NG
DL
M
I
V
I
N
G
K
SGAD
NE
Q
L
LV
E
I
EE
L
FN
T
K
A
Q
----
SG
SH
E
A
R
YA
T
----
IA
SA
K
K
HI
PE
S
NLA
V
ISV
N
G
L
F
AA
R
EA
R
QAL
QND
LNVM
L
FSDNVS
V
EDE
LA
LK
Q
LA
H
EKGLL
M
MGPDCGTAIING
A
A
L
C
F
G
N
A
V
R
RGNIG
IV
GASGTG
S
QEL
SV
RI
HEF
G
G
G
V
SQ
L
IGTGGRDLSE
K
IGG
LM
ML
D
A
I
G
ML
EN
D
P
Q
TE
I
IALISKPPAPAVARK
V
LERA
R
AC
R
KPVV
V
C
FLG
RG
E
TPVDEQ
G
L
Q
FA
RGTK
EAA
LK
AV
M
L
---
SGVKQEHLDLHTLNQ
P
LIT
DV
RA
RL
KPQQKY
IRGLF
C
GGTLC
D
E
T
MF
A
V
MEKH
S
-D
V
Y
SN
IQP
D
PEFR
L
KD
I
NR
S
IK
HT
F
LD
F
GDDDFT
N
GKPHPMIDPT
N
R
I
S
RL
I
E
E
AR
DP
E
VAV
I
V
M
D
F
VLGFG
S
HE
DP
V
G
S
T
I
E
A
IK
E
A
K
A
I
A
AA
E
G
R
E
L
II
L
A
Y
V
L
GT
D
L
D
TP
S
LE
QQ
S
QM
L
L
DAGVI
L
ASS
STN
T
G
LLA
REF
ICKGEEA
fig|155864.8.peg.360
Escherichia coli O157:H7 EDL933
MSVKIVIK
P
N
T
Y
F
DSVSLM
S
IS
T
R
A
N
KL
D
GV
E
QA
F
V
A
M
A
T
E
M
NK
GV
L
KNL
GL
LTPELE
Q
A
K
NG
DL
M
I
V
I
N
G
K
SGAD
NE
Q
L
LV
E
I
EE
L
FN
T
K
A
Q
----
SG
SH
E
A
R
YA
T
----
IA
SA
K
K
HI
PE
S
NLA
V
ISV
N
G
L
F
AA
R
EA
R
QAL
QND
LNVM
L
FSDNVS
V
EDE
LA
LK
Q
LA
H
EKGLL
M
MGPDCGTAIING
A
A
L
C
F
G
N
A
V
R
RGNIG
IV
GASGTG
S
QEL
SV
RI
HEF
G
G
G
V
SQ
L
IGTGGRDLSE
K
IGG
LM
ML
D
A
I
G
ML
EN
D
P
Q
TE
I
IALISKPPAPAVARK
V
LERA
R
AC
R
KPVV
V
C
FLG
RG
E
TPVDEQ
G
L
Q
FA
RGTK
EAA
LK
AV
M
L
---
SGVKQEHLDLHTLNQ
P
LIT
DV
RA
RL
KPQQKY
IRGLF
C
GGTLC
D
E
T
MF
A
V
MEKH
S
-D
V
Y
SN
IQP
D
PEFR
L
KD
I
NR
S
IK
HT
F
LD
F
GDDDFT
N
GKPHPMIDPT
N
R
I
S
RL
I
E
E
AR
DP
E
VAV
I
V
M
D
F
VLGFG
S
HE
DP
V
G
S
T
I
E
A
IK
E
A
K
A
I
A
AA
E
G
R
E
L
II
L
A
Y
V
L
GT
D
L
D
TP
S
LE
QQ
S
QM
L
L
DAGVI
L
ASS
STN
T
G
LLA
REF
ICKGEEA
fig|444454.5.peg.4830
Escherichia coli O157:H7 str. EC4024
MSVKIVIK
P
N
T
Y
F
DSVSLM
S
IS
T
R
A
N
KL
D
GV
E
QA
F
V
A
M
A
T
E
M
NK
GV
L
KNL
GL
LTPELE
Q
A
K
NG
DL
M
I
V
I
N
G
K
SGAD
NE
Q
L
LV
E
I
EE
L
FN
T
K
A
Q
----
SG
SH
E
A
R
YA
T
----
IA
SA
K
K
HI
PE
S
NLA
V
ISV
N
G
L
F
AA
R
EA
R
QAL
QND
LNVM
L
FSDNVS
V
EDE
LA
LK
Q
LA
H
EKGLL
M
MGPDCGTAIING
A
A
L
C
F
G
N
A
V
R
RGNIG
IV
GASGTG
S
QEL
SV
RI
HEF
G
G
G
V
SQ
L
IGTGGRDLSE
K
IGG
LM
ML
D
A
I
G
ML
EN
D
P
Q
TE
I
IALISKPPAPAVARK
V
LERA
R
AC
R
KPVV
V
C
FLG
RG
E
TPVDEQ
G
L
Q
FA
RGTK
EAA
LK
AV
M
L
---
SGVKQEHLDLHTLNQ
P
LIT
DV
RA
RL
KPQQKY
IRGLF
C
GGTLC
D
E
T
MF
A
V
MEKH
S
-D
V
Y
SN
IQP
D
PEFR
L
KD
I
NR
S
IK
HT
F
LD
F
GDDDFT
N
GKPHPMIDPT
N
R
I
S
RL
I
E
E
AR
DP
E
VAV
I
V
M
D
F
VLGFG
S
HE
DP
V
G
S
T
I
E
A
IK
E
A
K
A
I
A
AA
E
G
R
E
L
II
L
A
Y
V
L
GT
D
L
D
TP
S
LE
QQ
S
QM
L
L
DAGVI
L
ASS
STN
T
G
LLA
REF
ICKGEEA
fig|444449.5.peg.5171
Escherichia coli O157:H7 str. EC4042
MSVKIVIK
P
N
T
Y
F
DSVSLM
S
IS
T
R
A
N
KL
D
GV
E
QA
F
V
A
M
A
T
E
M
NK
GV
L
KNL
GL
LTPELE
Q
A
K
NG
DL
M
I
V
I
N
G
K
SGAD
NE
Q
L
LV
E
I
EE
L
FN
T
K
A
Q
----
SG
SH
E
A
R
YA
T
----
IA
SA
K
K
HI
PE
S
NLA
V
ISV
N
G
L
F
AA
R
EA
R
QAL
QND
LNVM
L
FSDNVS
V
EDE
LA
LK
Q
LA
H
EKGLL
M
MGPDCGTAIING
A
A
L
C
F
G
N
A
V
R
RGNIG
IV
GASGTG
S
QEL
SV
RI
HEF
G
G
G
V
SQ
L
IGTGGRDLSE
K
IGG
LM
ML
D
A
I
G
ML
EN
D
P
Q
TE
I
IALISKPPAPAVARK
V
LERA
R
AC
R
KPVV
V
C
FLG
RG
E
TPVDEQ
G
L
Q
FA
RGTK
EAA
LK
AV
M
L
---
SGVKQEHLDLHTLNQ
P
LIT
DV
RA
RL
KPQQKY
IRGLF
C
GGTLC
D
E
T
MF
A
V
MEKH
S
-D
V
Y
SN
IQP
D
PEFR
L
KD
I
NR
S
IK
HT
F
LD
F
GDDDFT
N
GKPHPMIDPT
N
R
I
S
RL
I
E
E
AR
DP
E
VAV
I
V
M
D
F
VLGFG
S
HE
DP
V
G
S
T
I
E
A
IK
E
A
K
A
I
A
AA
E
G
R
E
L
II
L
A
Y
V
L
GT
D
L
D
TP
S
LE
QQ
S
QM
L
L
DAGVI
L
ASS
STN
T
G
LLA
REF
ICKGEEA
fig|444448.5.peg.3047
Escherichia coli O157:H7 str. EC4045
MSVKIVIK
P
N
T
Y
F
DSVSLM
S
IS
T
R
A
N
KL
D
GV
E
QA
F
V
A
M
A
T
E
M
NK
GV
L
KNL
GL
LTPELE
Q
A
K
NG
DL
M
I
V
I
N
G
K
SGAD
NE
Q
L
LV
E
I
EE
L
FN
T
K
A
Q
----
SG
SH
E
A
R
YA
T
----
IA
SA
K
K
HI
PE
S
NLA
V
ISV
N
G
L
F
AA
R
EA
R
QAL
QND
LNVM
L
FSDNVS
V
EDE
LA
LK
Q
LA
H
EKGLL
M
MGPDCGTAIING
A
A
L
C
F
G
N
A
V
R
RGNIG
IV
GASGTG
S
QEL
SV
RI
HEF
G
G
G
V
SQ
L
IGTGGRDLSE
K
IGG
LM
ML
D
A
I
G
ML
EN
D
P
Q
TE
I
IALISKPPAPAVARK
V
LERA
R
AC
R
KPVV
V
C
FLG
RG
E
TPVDEQ
G
L
Q
FA
RGTK
EAA
LK
AV
M
L
---
SGVKQEHLDLHTLNQ
P
LIT
DV
RA
RL
KPQQKY
IRGLF
C
GGTLC
D
E
T
MF
A
V
MEKH
S
-D
V
Y
SN
IQP
D
PEFR
L
KD
I
NR
S
IK
HT
F
LD
F
GDDDFT
N
GKPHPMIDPT
N
R
I
S
RL
I
E
E
AR
DP
E
VAV
I
V
M
D
F
VLGFG
S
HE
DP
V
G
S
T
I
E
A
IK
E
A
K
A
I
A
AA
E
G
R
E
L
II
L
A
Y
V
L
GT
D
L
D
TP
S
LE
QQ
S
QM
L
L
DAGVI
L
ASS
STN
T
G
LLA
REF
ICKGEEA
fig|444453.5.peg.4018
Escherichia coli O157:H7 str. EC4076
MSVKIVIK
P
N
T
Y
F
DSVSLM
S
IS
T
R
A
N
KL
D
GV
E
QA
F
V
A
M
A
T
E
M
NK
GV
L
KNL
GL
LTPELE
Q
A
K
NG
DL
M
I
V
I
N
G
K
SGAD
NE
Q
L
LV
E
I
EE
L
FN
T
K
A
Q
----
SG
SH
E
A
R
YA
T
----
IA
SA
K
K
HI
PE
S
NLA
V
ISV
N
G
L
F
AA
R
EA
R
QAL
QND
LNVM
L
FSDNVS
V
EDE
LA
LK
Q
LA
H
EKGLL
M
MGPDCGTAIING
A
A
L
C
F
G
N
A
V
R
RGNIG
IV
GASGTG
S
QEL
SV
RI
HEF
G
G
G
V
SQ
L
IGTGGRDLSE
K
IGG
LM
ML
D
A
I
G
ML
EN
D
P
Q
TE
I
IALISKPPAPAVARK
V
LERA
R
AC
R
KPVV
V
C
FLG
RG
E
TPVDEQ
G
L
Q
FA
RGTK
EAA
LK
AV
M
L
---
SGVKQEHLDLHTLNQ
P
LIT
DV
RA
RL
KPQQKY
IRGLF
C
GGTLC
D
E
T
MF
A
V
MEKH
S
-D
V
Y
SN
IQP
D
PEFR
L
KD
I
NR
S
IK
HT
F
LD
F
GDDDFT
N
GKPHPMIDPT
N
R
I
S
RL
I
E
E
AR
DP
E
VAV
I
V
M
D
F
VLGFG
S
HE
DP
V
G
S
T
I
E
A
IK
E
A
K
A
I
A
AA
E
G
R
E
L
II
L
A
Y
V
L
GT
D
L
D
TP
S
LE
QQ
S
QM
L
L
DAGVI
L
ASS
STN
T
G
LLA
REF
ICKGEEA
fig|444452.5.peg.2212
Escherichia coli O157:H7 str. EC4113
MSVKIVIK
P
N
T
Y
F
DSVSLM
S
IS
T
R
A
N
KL
D
GV
E
QA
F
V
A
M
A
T
E
M
NK
GV
L
KNL
GL
LTPELE
Q
A
K
NG
DL
M
I
V
I
N
G
K
SGAD
NE
Q
L
LV
E
I
EE
L
FN
T
K
A
Q
----
SG
SH
E
A
R
YA
T
----
IA
SA
K
K
HI
PE
S
NLA
V
ISV
N
G
L
F
AA
R
EA
R
QAL
QND
LNVM
L
FSDNVS
V
EDE
LA
LK
Q
LA
H
EKGLL
M
MGPDCGTAIING
A
A
L
C
F
G
N
A
V
R
RGNIG
IV
GASGTG
S
QEL
SV
RI
HEF
G
G
G
V
SQ
L
IGTGGRDLSE
K
IGG
LM
ML
D
A
I
G
ML
EN
D
P
Q
TE
I
IALISKPPAPAVARK
V
LERA
R
AC
R
KPVV
V
C
FLG
RG
E
TPVDEQ
G
L
Q
FA
RGTK
EAA
LK
AV
M
L
---
SGVKQEHLDLHTLNQ
P
LIT
DV
RA
RL
KPQQKY
IRGLF
C
GGTLC
D
E
T
MF
A
V
MEKH
S
-D
V
Y
SN
IQP
D
PEFR
L
KD
I
NR
S
IK
HT
F
LD
F
GDDDFT
N
GKPHPMIDPT
N
R
I
S
RL
I
E
E
AR
DP
E
VAV
I
V
M
D
F
VLGFG
S
HE
DP
V
G
S
T
I
E
A
IK
E
A
K
A
I
A
AA
E
G
R
E
L
II
L
A
Y
V
L
GT
D
L
D
TP
S
LE
QQ
S
QM
L
L
DAGVI
L
ASS
STN
T
G
LLA
REF
ICKGEEA
fig|444450.8.peg.509
Escherichia coli O157:H7 str. EC4115
MSVKIVIK
P
N
T
Y
F
DSVSLM
S
IS
T
R
A
N
KL
D
GV
E
QA
F
V
A
M
A
T
E
M
NK
GV
L
KNL
GL
LTPELE
Q
A
K
NG
DL
M
I
V
I
N
G
K
SGAD
NE
Q
L
LV
E
I
EE
L
FN
T
K
A
Q
----
SG
SH
E
A
R
YA
T
----
IA
SA
K
K
HI
PE
S
NLA
V
ISV
N
G
L
F
AA
R
EA
R
QAL
QND
LNVM
L
FSDNVS
V
EDE
LA
LK
Q
LA
H
EKGLL
M
MGPDCGTAIING
A
A
L
C
F
G
N
A
V
R
RGNIG
IV
GASGTG
S
QEL
SV
RI
HEF
G
G
G
V
SQ
L
IGTGGRDLSE
K
IGG
LM
ML
D
A
I
G
ML
EN
D
P
Q
TE
I
IALISKPPAPAVARK
V
LERA
R
AC
R
KPVV
V
C
FLG
RG
E
TPVDEQ
G
L
Q
FA
RGTK
EAA
LK
AV
M
L
---
SGVKQEHLDLHTLNQ
P
LIT
DV
RA
RL
KPQQKY
IRGLF
C
GGTLC
D
E
T
MF
A
V
MEKH
S
-D
V
Y
SN
IQP
D
PEFR
L
KD
I
NR
S
IK
HT
F
LD
F
GDDDFT
N
GKPHPMIDPT
N
R
I
S
RL
I
E
E
AR
DP
E
VAV
I
V
M
D
F
VLGFG
S
HE
DP
V
G
S
T
I
E
A
IK
E
A
K
A
I
A
AA
E
G
R
E
L
II
L
A
Y
V
L
GT
D
L
D
TP
S
LE
QQ
S
QM
L
L
DAGVI
L
ASS
STN
T
G
LLA
REF
ICKGEEA
fig|444451.5.peg.2955
Escherichia coli O157:H7 str. EC4196
MSVKIVIK
P
N
T
Y
F
DSVSLM
S
IS
T
R
A
N
KL
D
GV
E
QA
F
V
A
M
A
T
E
M
NK
GV
L
KNL
GL
LTPELE
Q
A
K
NG
DL
M
I
V
I
N
G
K
SGAD
NE
Q
L
LV
E
I
EE
L
FN
T
K
A
Q
----
SG
SH
E
A
R
YA
T
----
IA
SA
K
K
HI
PE
S
NLA
V
ISV
N
G
L
F
AA
R
EA
R
QAL
QND
LNVM
L
FSDNVS
V
EDE
LA
LK
Q
LA
H
EKGLL
M
MGPDCGTAIING
A
A
L
C
F
G
N
A
V
R
RGNIG
IV
GASGTG
S
QEL
SV
RI
HEF
G
G
G
V
SQ
L
IGTGGRDLSE
K
IGG
LM
ML
D
A
I
G
ML
EN
D
P
Q
TE
I
IALISKPPAPAVARK
V
LERA
R
AC
R
KPVV
V
C
FLG
RG
E
TPVDEQ
G
L
Q
FA
RGTK
EAA
LK
AV
M
L
---
SGVKQEHLDLHTLNQ
P
LIT
DV
RA
RL
KPQQKY
IRGLF
C
GGTLC
D
E
T
MF
A
V
MEKH
S
-D
V
Y
SN
IQP
D
PEFR
L
KD
I
NR
S
IK
HT
F
LD
F
GDDDFT
N
GKPHPMIDPT
N
R
I
S
RL
I
E
E
AR
DP
E
VAV
I
V
M
D
F
VLGFG
S
HE
DP
V
G
S
T
I
E
A
IK
E
A
K
A
I
A
AA
E
G
R
E
L
II
L
A
Y
V
L
GT
D
L
D
TP
S
LE
QQ
S
QM
L
L
DAGVI
L
ASS
STN
T
G
LLA
REF
ICKGEEA
fig|444447.5.peg.3217
Escherichia coli O157:H7 str. EC4206
MSVKIVIK
P
N
T
Y
F
DSVSLM
S
IS
T
R
A
N
KL
D
GV
E
QA
F
V
A
M
A
T
E
M
NK
GV
L
KNL
GL
LTPELE
Q
A
K
NG
DL
M
I
V
I
N
G
K
SGAD
NE
Q
L
LV
E
I
EE
L
FN
T
K
A
Q
----
SG
SH
E
A
R
YA
T
----
IA
SA
K
K
HI
PE
S
NLA
V
ISV
N
G
L
F
AA
R
EA
R
QAL
QND
LNVM
L
FSDNVS
V
EDE
LA
LK
Q
LA
H
EKGLL
M
MGPDCGTAIING
A
A
L
C
F
G
N
A
V
R
RGNIG
IV
GASGTG
S
QEL
SV
RI
HEF
G
G
G
V
SQ
L
IGTGGRDLSE
K
IGG
LM
ML
D
A
I
G
ML
EN
D
P
Q
TE
I
IALISKPPAPAVARK
V
LERA
R
AC
R
KPVV
V
C
FLG
RG
E
TPVDEQ
G
L
Q
FA
RGTK
EAA
LK
AV
M
L
---
SGVKQEHLDLHTLNQ
P
LIT
DV
RA
RL
KPQQKY
IRGLF
C
GGTLC
D
E
T
MF
A
V
MEKH
S
-D
V
Y
SN
IQP
D
PEFR
L
KD
I
NR
S
IK
HT
F
LD
F
GDDDFT
N
GKPHPMIDPT
N
R
I
S
RL
I
E
E
AR
DP
E
VAV
I
V
M
D
F
VLGFG
S
HE
DP
V
G
S
T
I
E
A
IK
E
A
K
A
I
A
AA
E
G
R
E
L
II
L
A
Y
V
L
GT
D
L
D
TP
S
LE
QQ
S
QM
L
L
DAGVI
L
ASS
STN
T
G
LLA
REF
ICKGEEA
fig|478004.5.peg.2645
Escherichia coli O157:H7 str. EC4401
MSVKIVIK
P
N
T
Y
F
DSVSLM
S
IS
T
R
A
N
KL
D
GV
E
QA
F
V
A
M
A
T
E
M
NK
GV
L
KNL
GL
LTPELE
Q
A
K
NG
DL
M
I
V
I
N
G
K
SGAD
NE
Q
L
LV
E
I
EE
L
FN
T
K
A
Q
----
SG
SH
E
A
R
YA
T
----
IA
SA
K
K
HI
PE
S
NLA
V
ISV
N
G
L
F
AA
R
EA
R
QAL
QND
LNVM
L
FSDNVS
V
EDE
LA
LK
Q
LA
H
EKGLL
M
MGPDCGTAIING
A
A
L
C
F
G
N
A
V
R
RGNIG
IV
GASGTG
S
QEL
SV
RI
HEF
G
G
G
V
SQ
L
IGTGGRDLSE
K
IGG
LM
ML
D
A
I
G
ML
EN
D
P
Q
TE
I
IALISKPPAPAVARK
V
LERA
R
AC
R
KPVV
V
C
FLG
RG
E
TPVDEQ
G
L
Q
FA
RGTK
EAA
LK
AV
M
L
---
SGVKQEHLDLHTLNQ
P
LIT
DV
RA
RL
KPQQKY
IRGLF
C
GGTLC
D
E
T
MF
A
V
MEKH
S
-D
V
Y
SN
IQP
D
PEFR
L
KD
I
NR
S
IK
HT
F
LD
F
GDDDFT
N
GKPHPMIDPT
N
R
I
S
RL
I
E
E
AR
DP
E
VAV
I
V
M
D
F
VLGFG
S
HE
DP
V
G
S
T
I
E
A
IK
E
A
K
A
I
A
AA
E
G
R
E
L
II
L
A
Y
V
L
GT
D
L
D
TP
S
LE
QQ
S
QM
L
L
DAGVI
L
ASS
STN
T
G
LLA
REF
ICKGEEA
fig|478005.5.peg.3575
Escherichia coli O157:H7 str. EC4486
MSVKIVIK
P
N
T
Y
F
DSVSLM
S
IS
T
R
A
N
KL
D
GV
E
QA
F
V
A
M
A
T
E
M
NK
GV
L
KNL
GL
LTPELE
Q
A
K
NG
DL
M
I
V
I
N
G
K
SGAD
NE
Q
L
LV
E
I
EE
L
FN
T
K
A
Q
----
SG
SH
E
A
R
YA
T
----
IA
SA
K
K
HI
PE
S
NLA
V
ISV
N
G
L
F
AA
R
EA
R
QAL
QND
LNVM
L
FSDNVS
V
EDE
LA
LK
Q
LA
H
EKGLL
M
MGPDCGTAIING
A
A
L
C
F
G
N
A
V
R
RGNIG
IV
GASGTG
S
QEL
SV
RI
HEF
G
G
G
V
SQ
L
IGTGGRDLSE
K
IGG
LM
ML
D
A
I
G
ML
EN
D
P
Q
TE
I
IALISKPPAPAVARK
V
LERA
R
AC
R
KPVV
V
C
FLG
RG
E
TPVDEQ
G
L
Q
FA
RGTK
EAA
LK
AV
M
L
---
SGVKQEHLDLHTLNQ
P
LIT
DV
RA
RL
KPQQKY
IRGLF
C
GGTLC
D
E
T
MF
A
V
MEKH
S
-D
V
Y
SN
IQP
D
PEFR
L
KD
I
NR
S
IK
HT
F
LD
F
GDDDFT
N
GKPHPMIDPT
N
R
I
S
RL
I
E
E
AR
DP
E
VAV
I
V
M
D
F
VLGFG
S
HE
DP
V
G
S
T
I
E
A
IK
E
A
K
A
I
A
AA
E
G
R
E
L
II
L
A
Y
V
L
GT
D
L
D
TP
S
LE
QQ
S
QM
L
L
DAGVI
L
ASS
STN
T
G
LLA
REF
ICKGEEA
fig|478006.5.peg.2453
Escherichia coli O157:H7 str. EC4501
MSVKIVIK
P
N
T
Y
F
DSVSLM
S
IS
T
R
A
N
KL
D
GV
E
QA
F
V
A
M
A
T
E
M
NK
GV
L
KNL
GL
LTPELE
Q
A
K
NG
DL
M
I
V
I
N
G
K
SGAD
NE
Q
L
LV
E
I
EE
L
FN
T
K
A
Q
----
SG
SH
E
A
R
YA
T
----
IA
SA
K
K
HI
PE
S
NLA
V
ISV
N
G
L
F
AA
R
EA
R
QAL
QND
LNVM
L
FSDNVS
V
EDE
LA
LK
Q
LA
H
EKGLL
M
MGPDCGTAIING
A
A
L
C
F
G
N
A
V
R
RGNIG
IV
GASGTG
S
QEL
SV
RI
HEF
G
G
G
V
SQ
L
IGTGGRDLSE
K
IGG
LM
ML
D
A
I
G
ML
EN
D
P
Q
TE
I
IALISKPPAPAVARK
V
LERA
R
AC
R
KPVV
V
C
FLG
RG
E
TPVDEQ
G
L
Q
FA
RGTK
EAA
LK
AV
M
L
---
SGVKQEHLDLHTLNQ
P
LIT
DV
RA
RL
KPQQKY
IRGLF
C
GGTLC
D
E
T
MF
A
V
MEKH
S
-D
V
Y
SN
IQP
D
PEFR
L
KD
I
NR
S
IK
HT
F
LD
F
GDDDFT
N
GKPHPMIDPT
N
R
I
S
RL
I
E
E
AR
DP
E
VAV
I
V
M
D
F
VLGFG
S
HE
DP
V
G
S
T
I
E
A
IK
E
A
K
A
I
A
AA
E
G
R
E
L
II
L
A
Y
V
L
GT
D
L
D
TP
S
LE
QQ
S
QM
L
L
DAGVI
L
ASS
STN
T
G
LLA
REF
ICKGEEA
fig|478007.5.peg.2464
Escherichia coli O157:H7 str. EC508
MSVKIVIK
P
N
T
Y
F
DSVSLM
S
IS
T
R
A
N
KL
D
GV
E
QA
F
V
A
M
A
T
E
M
NK
GV
L
KNL
GL
LTPELE
Q
A
K
NG
DL
M
I
V
I
N
G
K
SGAD
NE
Q
L
LV
E
I
EE
L
FN
T
K
A
Q
----
SG
SH
E
A
R
YA
T
----
IA
SA
K
K
HI
PE
S
NLA
V
ISV
N
G
L
F
AA
R
EA
R
QAL
QND
LNVM
L
FSDNVS
V
EDE
LA
LK
Q
LA
H
EKGLL
M
MGPDCGTAIING
A
A
L
C
F
G
N
A
V
R
RGNIG
IV
GASGTG
S
QEL
SV
RI
HEF
G
G
G
V
SQ
L
IGTGGRDLSE
K
IGG
LM
ML
D
A
I
G
ML
EN
D
P
Q
TE
I
IALISKPPAPAVARK
V
LERA
R
AC
R
KPVV
V
C
FLG
RG
E
TPVDEQ
G
L
Q
FA
RGTK
EAA
LK
AV
M
L
---
SGVKQEHLDLHTLNQ
P
LIT
DV
RA
RL
KPQQKY
IRGLF
C
GGTLC
D
E
T
MF
A
V
MEKH
S
-D
V
Y
SN
IQP
D
PEFR
L
KD
I
NR
S
IK
HT
F
LD
F
GDDDFT
N
GKPHPMIDPT
N
R
I
S
RL
I
E
E
AR
DP
E
VAV
I
V
M
D
F
VLGFG
S
HE
DP
V
G
S
T
I
E
A
IK
E
A
K
A
I
A
AA
E
G
R
E
L
II
L
A
Y
V
L
GT
D
L
D
TP
S
LE
QQ
S
QM
L
L
DAGVI
L
ASS
STN
T
G
LLA
REF
ICKGEEA
fig|478008.5.peg.3787
Escherichia coli O157:H7 str. EC869
MSVKIVIK
P
N
T
Y
F
DSVSLM
S
IS
T
R
A
N
KL
D
GV
E
QA
F
V
A
M
A
T
E
M
NK
GV
L
KNL
GL
LTPELE
Q
A
K
NG
DL
M
I
V
I
N
G
K
SGAD
NE
Q
L
LV
E
I
EE
L
FN
T
K
A
Q
----
SG
SH
E
A
R
YA
T
----
IA
SA
K
K
HI
PE
S
NLA
V
ISV
N
G
L
F
AA
R
EA
R
QAL
QND
LNVM
L
FSDNVS
V
EDE
LA
LK
Q
LA
H
EKGLL
M
MGPDCGTAIING
A
A
L
C
F
G
N
A
V
R
RGNIG
IV
GASGTG
S
QEL
SV
RI
HEF
G
G
G
V
SQ
L
IGTGGRDLSE
K
IGG
LM
ML
D
A
I
G
ML
EN
D
P
Q
TE
I
IALISKPPAPAVARK
V
LERA
R
AC
R
KPVV
V
C
FLG
RG
E
TPVDEQ
G
L
Q
FA
RGTK
EAA
LK
AV
M
L
---
SGVKQEHLDLHTLNQ
P
LIT
DV
RA
RL
KPQQKY
IRGLF
C
GGTLC
D
E
T
MF
A
V
MEKH
S
-D
V
Y
SN
IQP
D
PEFR
L
KD
I
NR
S
IK
HT
F
LD
F
GDDDFT
N
GKPHPMIDPT
N
R
I
S
RL
I
E
E
AR
DP
E
VAV
I
V
M
D
F
VLGFG
S
HE
DP
V
G
S
T
I
E
A
IK
E
A
K
A
I
A
AA
E
G
R
E
L
II
L
A
Y
V
L
GT
D
L
D
TP
S
LE
QQ
S
QM
L
L
DAGVI
L
ASS
STN
T
G
LLA
REF
ICKGEEA
fig|637388.3.peg.848
Escherichia coli O157:H7 str. FRIK2000
MSVKIVIK
P
N
T
Y
F
DSVSLM
S
IS
T
R
A
N
KL
D
GV
E
QA
F
V
A
M
A
T
E
M
NK
GV
L
KNL
GL
LTPELE
Q
A
K
NG
DL
M
I
V
I
N
G
K
SGAD
NE
Q
L
LV
E
I
EE
L
FN
T
K
A
Q
----
SG
SH
E
A
R
YA
T
----
IA
SA
K
K
HI
PE
S
NLA
V
ISV
N
G
L
F
AA
R
EA
R
QAL
QND
LNVM
L
FSDNVS
V
EDE
LA
LK
Q
LA
H
EKGLL
M
MGPDCGTAIING
A
A
L
C
F
G
N
A
V
R
RGNIG
IV
GASGTG
S
QEL
SV
RI
HEF
G
G
G
V
SQ
L
IGTGGRDLSE
K
IGG
LM
ML
D
A
I
G
ML
EN
D
P
Q
TE
I
IALISKPPAPAVARK
V
LERA
R
AC
R
KPVV
V
C
FLG
RG
E
TPVDEQ
G
L
Q
FA
RGTK
EAA
LK
AV
M
L
---
SGVKQEHLDLHTLNQ
P
LIT
DV
RA
RL
KPQQKY
IRGLF
C
GGTLC
D
E
T
MF
A
V
MEKH
S
-D
V
Y
SN
IQP
D
PEFR
L
KD
I
NR
S
IK
HT
F
LD
F
GDDDFT
N
GKPHPMIDPT
N
R
I
S
RL
I
E
E
AR
DP
E
VAV
I
V
M
D
F
VLGFG
S
HE
DP
V
G
S
T
I
E
A
IK
E
A
K
A
I
A
AA
E
G
R
E
L
II
L
A
Y
V
L
GT
D
L
D
TP
S
LE
QQ
S
QM
L
L
DAGVI
L
ASS
STN
T
G
LLA
REF
ICKGEEA
fig|570506.3.peg.1856
Escherichia coli O157:H7 str. FRIK966
MSVKIVIK
P
N
T
Y
F
DSVSLM
S
IS
T
R
A
N
KL
D
GV
E
QA
F
V
A
M
A
T
E
M
NK
GV
L
KNL
GL
LTPELE
Q
A
K
NG
DL
M
I
V
I
N
G
K
SGAD
NE
Q
L
LV
E
I
EE
L
FN
T
K
A
Q
----
SG
SH
E
A
R
YA
T
----
IA
SA
K
K
HI
PE
S
NLA
V
ISV
N
G
L
F
AA
R
EA
R
QAL
QND
LNVM
L
FSDNVS
V
EDE
LA
LK
Q
LA
H
EKGLL
M
MGPDCGTAIING
A
A
L
C
F
G
N
A
V
R
RGNIG
IV
GASGTG
S
QEL
SV
RI
HEF
G
G
G
V
SQ
L
IGTGGRDLSE
K
IGG
LM
ML
D
A
I
G
ML
EN
D
P
Q
TE
I
IALISKPPAPAVARK
V
LERA
R
AC
R
KPVV
V
C
FLG
RG
E
TPVDEQ
G
L
Q
FA
RGTK
EAA
LK
AV
M
L
---
SGVKQEHLDLHTLNQ
P
LIT
DV
RA
RL
KPQQKY
IRGLF
C
GGTLC
D
E
T
MF
A
V
MEKH
S
-D
V
Y
SN
IQP
D
PEFR
L
KD
I
NR
S
IK
HT
F
LD
F
GDDDFT
N
GKPHPMIDPT
N
R
I
S
RL
I
E
E
AR
DP
E
VAV
I
V
M
D
F
VLGFG
S
HE
DP
V
G
S
T
I
E
A
IK
E
A
K
A
I
A
AA
E
G
R
E
L
II
L
A
Y
V
L
GT
D
L
D
TP
S
LE
QQ
S
QM
L
L
DAGVI
L
ASS
STN
T
G
LLA
REF
ICKGEEA
fig|386585.9.peg.461
Escherichia coli O157:H7 str. Sakai
MSVKIVIK
P
N
T
Y
F
DSVSLM
S
IS
T
R
A
N
KL
D
GV
E
QA
F
V
A
M
A
T
E
M
NK
GV
L
KNL
GL
LTPELE
Q
A
K
NG
DL
M
I
V
I
N
G
K
SGAD
NE
Q
L
LV
E
I
EE
L
FN
T
K
A
Q
----
SG
SH
E
A
R
YA
T
----
IA
SA
K
K
HI
PE
S
NLA
V
ISV
N
G
L
F
AA
R
EA
R
QAL
QND
LNVM
L
FSDNVS
V
EDE
LA
LK
Q
LA
H
EKGLL
M
MGPDCGTAIING
A
A
L
C
F
G
N
A
V
R
RGNIG
IV
GASGTG
S
QEL
SV
RI
HEF
G
G
G
V
SQ
L
IGTGGRDLSE
K
IGG
LM
ML
D
A
I
G
ML
EN
D
P
Q
TE
I
IALISKPPAPAVARK
V
LERA
R
AC
R
KPVV
V
C
FLG
RG
E
TPVDEQ
G
L
Q
FA
RGTK
EAA
LK
AV
M
L
---
SGVKQEHLDLHTLNQ
P
LIT
DV
RA
RL
KPQQKY
IRGLF
C
GGTLC
D
E
T
MF
A
V
MEKH
S
-D
V
Y
SN
IQP
D
PEFR
L
KD
I
NR
S
IK
HT
F
LD
F
GDDDFT
N
GKPHPMIDPT
N
R
I
S
RL
I
E
E
AR
DP
E
VAV
I
V
M
D
F
VLGFG
S
HE
DP
V
G
S
T
I
E
A
IK
E
A
K
A
I
A
AA
E
G
R
E
L
II
L
A
Y
V
L
GT
D
L
D
TP
S
LE
QQ
S
QM
L
L
DAGVI
L
ASS
STN
T
G
LLA
REF
ICKGEEA
fig|544404.4.peg.374
Escherichia coli O157:H7 str. TW14359
MSVKIVIK
P
N
T
Y
F
DSVSLM
S
IS
T
R
A
N
KL
D
GV
E
QA
F
V
A
M
A
T
E
M
NK
GV
L
KNL
GL
LTPELE
Q
A
K
NG
DL
M
I
V
I
N
G
K
SGAD
NE
Q
L
LV
E
I
EE
L
FN
T
K
A
Q
----
SG
SH
E
A
R
YA
T
----
IA
SA
K
K
HI
PE
S
NLA
V
ISV
N
G
L
F
AA
R
EA
R
QAL
QND
LNVM
L
FSDNVS
V
EDE
LA
LK
Q
LA
H
EKGLL
M
MGPDCGTAIING
A
A
L
C
F
G
N
A
V
R
RGNIG
IV
GASGTG
S
QEL
SV
RI
HEF
G
G
G
V
SQ
L
IGTGGRDLSE
K
IGG
LM
ML
D
A
I
G
ML
EN
D
P
Q
TE
I
IALISKPPAPAVARK
V
LERA
R
AC
R
KPVV
V
C
FLG
RG
E
TPVDEQ
G
L
Q
FA
RGTK
EAA
LK
AV
M
L
---
SGVKQEHLDLHTLNQ
P
LIT
DV
RA
RL
KPQQKY
IRGLF
C
GGTLC
D
E
T
MF
A
V
MEKH
S
-D
V
Y
SN
IQP
D
PEFR
L
KD
I
NR
S
IK
HT
F
LD
F
GDDDFT
N
GKPHPMIDPT
N
R
I
S
RL
I
E
E
AR
DP
E
VAV
I
V
M
D
F
VLGFG
S
HE
DP
V
G
S
T
I
E
A
IK
E
A
K
A
I
A
AA
E
G
R
E
L
II
L
A
Y
V
L
GT
D
L
D
TP
S
LE
QQ
S
QM
L
L
DAGVI
L
ASS
STN
T
G
LLA
REF
ICKGEEA
fig|502346.5.peg.901
Escherichia coli O157:H7 str. TW14588
MSVKIVIK
P
N
T
Y
F
DSVSLM
S
IS
T
R
A
N
KL
D
GV
E
QA
F
V
A
M
A
T
E
M
NK
GV
L
KNL
GL
LTPELE
Q
A
K
NG
DL
M
I
V
I
N
G
K
SGAD
NE
Q
L
LV
E
I
EE
L
FN
T
K
A
Q
----
SG
SH
E
A
R
YA
T
----
IA
SA
K
K
HI
PE
S
NLA
V
ISV
N
G
L
F
AA
R
EA
R
QAL
QND
LNVM
L
FSDNVS
V
EDE
LA
LK
Q
LA
H
EKGLL
M
MGPDCGTAIING
A
A
L
C
F
G
N
A
V
R
RGNIG
IV
GASGTG
S
QEL
SV
RI
HEF
G
G
G
V
SQ
L
IGTGGRDLSE
K
IGG
LM
ML
D
A
I
G
ML
EN
D
P
Q
TE
I
IALISKPPAPAVARK
V
LERA
R
AC
R
KPVV
V
C
FLG
RG
E
TPVDEQ
G
L
Q
FA
RGTK
EAA
LK
AV
M
L
---
SGVKQEHLDLHTLNQ
P
LIT
DV
RA
RL
KPQQKY
IRGLF
C
GGTLC
D
E
T
MF
A
V
MEKH
S
-D
V
Y
SN
IQP
D
PEFR
L
KD
I
NR
S
IK
HT
F
LD
F
GDDDFT
N
GKPHPMIDPT
N
R
I
S
RL
I
E
E
AR
DP
E
VAV
I
V
M
D
F
VLGFG
S
HE
DP
V
G
S
T
I
E
A
IK
E
A
K
A
I
A
AA
E
G
R
E
L
II
L
A
Y
V
L
GT
D
L
D
TP
S
LE
QQ
S
QM
L
L
DAGVI
L
ASS
STN
T
G
LLA
REF
ICKGEEA
fig|439855.10.peg.524
Escherichia coli SMS-3-5
MSVKIVIK
P
N
T
Y
F
DSVSLM
S
IS
T
R
A
N
KL
D
GV
E
QA
F
V
A
M
A
T
E
M
NK
GV
L
KNL
GL
LTPELE
Q
A
K
NG
DL
M
I
V
I
N
G
K
AGAD
NE
Q
L
LV
E
I
EE
L
FN
T
K
A
Q
----
SG
SH
E
A
R
YA
T
----
IA
SA
K
K
HI
PE
S
NLA
V
ISV
N
G
L
F
AA
R
EA
R
QAL
QND
LNVM
L
FSDNVS
V
EDE
LA
LK
Q
LA
H
EKGLL
L
MGPDCGTAIING
A
A
L
C
F
G
N
A
V
R
RGNIG
IV
GASGTG
S
QEL
SV
RI
HEF
G
G
G
V
SQ
L
IGTGGRDLSE
K
IGG
LM
M
F
D
A
I
G
ML
EN
D
P
Q
TE
I
I
V
LISKPPAPAVARK
V
LERA
R
AC
R
KPVV
V
C
FLG
RG
E
TPVDEQ
G
L
Q
FA
RGSK
EAA
LK
AV
M
L
---
SGVKQEHLDLHTLNQ
P
LIA
DV
RA
RL
KPQQKY
IRGLF
C
GGTLC
D
E
T
MF
A
V
MEKH
G
-D
V
Y
SN
IQP
D
PEFR
L
KD
I
NR
S
VK
HT
F
LD
F
GDDDFT
N
GKPHPMIDPT
N
R
I
S
RL
I
E
E
AR
DP
E
VA
LI
V
M
D
F
VLGFG
S
HE
DP
V
G
S
T
I
E
A
IK
E
A
K
A
I
A
AA
E
G
R
E
L
II
L
A
Y
V
L
GT
D
L
D
TP
S
LE
QQ
S
QM
L
L
DAGVI
L
ASS
STN
T
G
LLA
REF
ICKGEEA
fig|685038.3.peg.312
Escherichia coli O83:H1 str. NRG 857C
MSVKIVIK
P
N
T
Y
F
DSVSLM
S
IS
T
R
A
N
KL
D
GV
E
QA
F
V
A
M
A
T
E
M
NK
GV
L
KNL
GL
LTPELE
Q
A
K
NG
DL
M
I
V
I
N
G
K
SGVD
NE
Q
L
LA
E
I
EE
L
FN
T
K
A
Q
----
SG
SH
E
A
R
YA
T
----
IA
SA
K
K
HI
PE
S
NLA
V
ISV
N
G
L
F
AA
R
EA
R
Q
S
L
QND
LNVM
L
FSDNVS
V
EDE
LA
LK
Q
LA
H
EKGLL
M
MGPDCGTAIING
A
A
L
C
F
G
N
A
V
R
RGNIG
IV
GASGTG
S
QEL
SV
RI
HEF
G
G
G
V
SQ
L
IGTGGRDLSE
K
IGG
LM
ML
D
A
I
G
ML
EN
D
P
Q
TE
I
I
V
LISKPPAPAVARK
V
LERA
R
AC
R
KPVVA
C
FLG
RG
E
TPVDEQ
G
L
Q
FA
RGSK
EAA
LK
AV
M
L
---
SGVKQEHLDLHTLNQ
P
LIA
DV
RA
RL
QPQQKY
IRGLF
C
GGTLC
D
E
T
LF
A
V
MEKH
G
-D
V
Y
SN
IQP
D
PEFR
L
QD
I
NR
S
IK
HT
F
LD
F
GDDDFT
N
GKPHPMIDPT
N
R
I
S
RL
I
E
E
AR
DP
E
VAV
I
V
M
D
F
VLGFG
S
HE
DP
V
G
S
T
I
E
A
IK
E
A
K
A
I
A
AA
E
G
R
E
L
II
L
A
Y
V
L
GT
D
L
D
TP
S
LE
QQ
S
QM
L
L
DAGVI
L
ASS
STN
T
G
LLA
REF
ICKGEEA
fig|405955.13.peg.331
Escherichia coli APEC O1
MSVKIVIK
P
N
T
Y
F
DSVSLM
S
IS
T
R
A
N
KL
D
GV
E
QA
F
V
A
M
A
T
E
M
NK
GV
L
KNL
GL
LTPELE
Q
A
K
NG
DL
M
I
V
I
N
G
K
SGVD
NE
Q
L
LA
E
I
EE
L
FN
T
K
A
Q
----
SG
SH
E
A
R
YA
T
----
IA
SA
K
K
HI
PE
S
NLA
V
ISV
N
G
L
F
AA
R
EA
R
QAL
QND
LNVM
L
FSDNVS
V
EDE
LA
LK
Q
LA
H
EKGLL
M
MGPDCGTAIING
A
A
L
C
F
G
N
A
V
R
RGNIG
IV
GASGTG
S
QEL
SV
RI
HEF
G
G
G
V
SQ
L
IGTGGRDLSE
K
IGG
LM
ML
D
A
I
G
ML
EN
D
P
Q
TE
I
I
V
LISKPPAPAVARK
V
LERA
R
AC
R
KPVVA
C
FLG
RG
E
TPVDEQ
G
L
Q
FA
RGSK
EAA
LK
AV
M
L
---
SGVKQEHLDLHTLNQ
P
LIA
DV
RA
RL
QPQQKY
IRGLF
C
GGTLC
D
E
T
LF
A
V
MEKH
G
-D
V
Y
SN
IQP
D
PEFR
L
QD
I
NR
S
IK
HT
F
LD
F
GDDDFT
N
GKPHPMIDPT
N
R
I
S
R
V
I
E
E
AR
DP
E
VAV
I
V
M
D
F
VLGFG
S
HE
DP
V
G
S
T
I
E
A
IK
E
A
K
A
I
A
AA
E
G
R
E
L
II
L
A
Y
V
L
GT
D
L
D
TP
S
LE
QQ
S
QM
L
L
DAGVI
L
ASS
STN
T
G
LLA
REF
ICKGEEA
fig|405955.9.peg.270
Escherichia coli APEC O1
MSVKIVIK
P
N
T
Y
F
DSVSLM
S
IS
T
R
A
N
KL
D
GV
E
QA
F
V
A
M
A
T
E
M
NK
GV
L
KNL
GL
LTPELE
Q
A
K
NG
DL
M
I
V
I
N
G
K
SGVD
NE
Q
L
LA
E
I
EE
L
FN
T
K
A
Q
----
SG
SH
E
A
R
YA
T
----
IA
SA
K
K
HI
PE
S
NLA
V
ISV
N
G
L
F
AA
R
EA
R
QAL
QND
LNVM
L
FSDNVS
V
EDE
LA
LK
Q
LA
H
EKGLL
M
MGPDCGTAIING
A
A
L
C
F
G
N
A
V
R
RGNIG
IV
GASGTG
S
QEL
SV
RI
HEF
G
G
G
V
SQ
L
IGTGGRDLSE
K
IGG
LM
ML
D
A
I
G
ML
EN
D
P
Q
TE
I
I
V
LISKPPAPAVARK
V
LERA
R
AC
R
KPVVA
C
FLG
RG
E
TPVDEQ
G
L
Q
FA
RGSK
EAA
LK
AV
M
L
---
SGVKQEHLDLHTLNQ
P
LIA
DV
RA
RL
QPQQKY
IRGLF
C
GGTLC
D
E
T
LF
A
V
MEKH
G
-D
V
Y
SN
IQP
D
PEFR
L
QD
I
NR
S
IK
HT
F
LD
F
GDDDFT
N
GKPHPMIDPT
N
R
I
S
R
V
I
E
E
AR
DP
E
VAV
I
V
M
D
F
VLGFG
S
HE
DP
V
G
S
T
I
E
A
IK
E
A
K
A
I
A
AA
E
G
R
E
L
II
L
A
Y
V
L
GT
D
L
D
TP
S
LE
QQ
S
QM
L
L
DAGVI
L
ASS
STN
T
G
LLA
REF
ICKGEEA
fig|714962.3.peg.319
Escherichia coli IHE3034
MSVKIVIK
P
N
T
Y
F
DSVSLM
S
IS
T
R
A
N
KL
D
GV
E
QA
F
V
A
M
A
T
E
M
NK
GV
L
KNL
GL
LTPELE
Q
A
K
NG
DL
M
I
V
I
N
G
K
SGVD
NE
Q
L
LA
E
I
EE
L
FN
T
K
A
Q
----
SG
SH
E
A
R
YA
T
----
IA
SA
K
K
HI
PE
S
NLA
V
ISV
N
G
L
F
AA
R
EA
R
QAL
QND
LNVM
L
FSDNVS
V
EDE
LA
LK
Q
LA
H
EKGLL
M
MGPDCGTAIING
A
A
L
C
F
G
N
A
V
R
RGNIG
IV
GASGTG
S
QEL
SV
RI
HEF
G
G
G
V
SQ
L
IGTGGRDLSE
K
IGG
LM
ML
D
A
I
G
ML
EN
D
P
Q
TE
I
I
V
LISKPPAPAVARK
V
LERA
R
AC
R
KPVVA
C
FLG
RG
E
TPVDEQ
G
L
Q
FA
RGSK
EAA
LK
AV
M
L
---
SGVKQEHLDLHTLNQ
P
LIA
DV
RA
RL
QPQQKY
IRGLF
C
GGTLC
D
E
T
LF
A
V
MEKH
G
-D
V
Y
SN
IQP
D
PEFR
L
QD
I
NR
S
IK
HT
F
LD
F
GDDDFT
N
GKPHPMIDPT
N
R
I
S
R
V
I
E
E
AR
DP
E
VAV
I
V
M
D
F
VLGFG
S
HE
DP
V
G
S
T
I
E
A
IK
E
A
K
A
I
A
AA
E
G
R
E
L
II
L
A
Y
V
L
GT
D
L
D
TP
S
LE
QQ
S
QM
L
L
DAGVI
L
ASS
STN
T
G
LLA
REF
ICKGEEA
fig|585035.6.peg.323
Escherichia coli S88
MSVKIVIK
P
N
T
Y
F
DSVSLM
S
IS
T
R
A
N
KL
D
GV
E
QA
F
V
A
M
A
T
E
M
NK
GV
L
KNL
GL
LTPELE
Q
A
K
NG
DL
M
I
V
I
N
G
K
SGVD
NE
Q
L
LA
E
I
EE
L
FN
T
K
A
Q
----
SG
SH
E
A
R
YA
T
----
IA
SA
K
K
HI
PE
S
NLA
V
ISV
N
G
L
F
AA
R
EA
R
QAL
QND
LNVM
L
FSDNVS
V
EDE
LA
LK
Q
LA
H
EKGLL
M
MGPDCGTAIING
A
A
L
C
F
G
N
A
V
R
RGNIG
IV
GASGTG
S
QEL
SV
RI
HEF
G
G
G
V
SQ
L
IGTGGRDLSE
K
IGG
LM
ML
D
A
I
G
ML
EN
D
P
Q
TE
I
I
V
LISKPPAPAVARK
V
LERA
R
AC
R
KPVVA
C
FLG
RG
E
TPVDEQ
G
L
Q
FA
RGSK
EAA
LK
AV
M
L
---
SGVKQEHLDLHTLNQ
P
LIA
DV
RA
RL
QPQQKY
IRGLF
C
GGTLC
D
E
T
LF
A
V
MEKH
G
-D
V
Y
SN
IQP
D
PEFR
L
QD
I
NR
S
IK
HT
F
LD
F
GDDDFT
N
GKPHPMIDPT
N
R
I
S
R
V
I
E
E
AR
DP
E
VAV
I
V
M
D
F
VLGFG
S
HE
DP
V
G
S
T
I
E
A
IK
E
A
K
A
I
A
AA
E
G
R
E
L
II
L
A
Y
V
L
GT
D
L
D
TP
S
LE
QQ
S
QM
L
L
DAGVI
L
ASS
STN
T
G
LLA
REF
ICKGEEA
fig|869729.3.peg.3363
Escherichia coli UM146
MSVKIVIK
P
N
T
Y
F
DSVSLM
S
IS
T
R
A
N
KL
D
GV
E
QA
F
V
A
M
A
T
E
M
NK
GV
L
KNL
GL
LTPELE
Q
A
K
NG
DL
M
I
V
I
N
G
K
SGVD
NE
Q
L
LA
E
I
EE
L
FN
T
K
A
Q
----
SG
SH
E
A
R
YA
T
----
IA
SA
K
K
HI
PE
S
NLA
V
ISV
N
G
L
F
AA
R
EA
R
QAL
QND
LNVM
L
FSDNVS
V
EDE
LA
LK
Q
LA
H
EKGLL
M
MGPDCGTAIING
A
A
L
C
F
G
N
A
V
R
RGNIG
IV
GASGTG
S
QEL
SV
RI
HEF
G
G
G
V
SQ
L
IGTGGRDLSE
K
IGG
LM
ML
D
A
I
G
ML
EN
D
P
Q
TE
I
I
V
LISKPPAPAVARK
V
LERA
R
AC
R
KPVVA
C
FLG
RG
E
TPVDEQ
G
L
Q
FA
RGSK
EAA
LK
AV
M
L
---
SGVKQEHLDLHTLNQ
P
LIA
DV
RA
RL
QPQQKY
IRGLF
C
GGTLC
D
E
T
LF
A
V
MEKH
G
-D
V
Y
SN
IQP
D
PEFR
L
QD
I
NR
S
IK
HT
F
LD
F
GDDDFT
N
GKPHPMIDPT
N
R
I
S
R
V
I
E
E
AR
DP
E
VAV
I
V
M
D
F
VLGFG
S
HE
DP
V
G
S
T
I
E
A
IK
E
A
K
A
I
A
AA
E
G
R
E
L
II
L
A
Y
V
L
GT
D
L
D
TP
S
LE
QQ
S
QM
L
L
DAGVI
L
ASS
STN
T
G
LLA
REF
ICKGEEA
fig|364106.7.peg.460
Escherichia coli UTI89
MSVKIVIK
P
N
T
Y
F
DSVSLM
S
IS
T
R
A
N
KL
D
GV
E
QA
F
V
A
M
A
T
E
M
NK
GV
L
KNL
GL
LTPELE
Q
A
K
NG
DL
M
I
V
I
N
G
K
SGVD
NE
Q
L
LA
E
I
EE
L
FN
T
K
A
Q
----
SG
SH
E
A
R
YA
T
----
IA
SA
K
K
HI
PE
S
NLA
V
ISV
N
G
L
F
AA
R
EA
R
QAL
QND
LNVM
L
FSDNVS
V
EDE
LA
LK
Q
LA
H
EKGLL
M
MGPDCGTAIING
A
A
L
C
F
G
N
A
V
R
RGNIG
IV
GASGTG
S
QEL
SV
RI
HEF
G
G
G
V
SQ
L
IGTGGRDLSE
K
IGG
LM
ML
D
A
I
G
ML
EN
D
P
Q
TE
I
I
V
LISKPPAPAVARK
V
LERA
R
AC
R
KPVVA
C
FLG
RG
E
TPVDEQ
G
L
Q
FA
RGSK
EAA
LK
AV
M
L
---
SGVKQEHLDLHTLNQ
P
LIA
DV
RA
RL
QPQQKY
IRGLF
C
GGTLC
D
E
T
LF
A
V
MEKH
G
-D
V
Y
SN
IQP
D
PEFR
L
QD
I
NR
S
IK
HT
F
LD
F
GDDDFT
N
GKPHPMIDPT
N
R
I
S
R
V
I
E
E
AR
DP
E
VAV
I
V
M
D
F
VLGFG
S
HE
DP
V
G
S
T
I
E
A
IK
E
A
K
A
I
A
AA
E
G
R
E
L
II
L
A
Y
V
L
GT
D
L
D
TP
S
LE
QQ
S
QM
L
L
DAGVI
L
ASS
STN
T
G
LLA
REF
ICKGEEA
fig|364106.8.peg.458
Escherichia coli UTI89
MSVKIVIK
P
N
T
Y
F
DSVSLM
S
IS
T
R
A
N
KL
D
GV
E
QA
F
V
A
M
A
T
E
M
NK
GV
L
KNL
GL
LTPELE
Q
A
K
NG
DL
M
I
V
I
N
G
K
SGVD
NE
Q
L
LA
E
I
EE
L
FN
T
K
A
Q
----
SG
SH
E
A
R
YA
T
----
IA
SA
K
K
HI
PE
S
NLA
V
ISV
N
G
L
F
AA
R
EA
R
QAL
QND
LNVM
L
FSDNVS
V
EDE
LA
LK
Q
LA
H
EKGLL
M
MGPDCGTAIING
A
A
L
C
F
G
N
A
V
R
RGNIG
IV
GASGTG
S
QEL
SV
RI
HEF
G
G
G
V
SQ
L
IGTGGRDLSE
K
IGG
LM
ML
D
A
I
G
ML
EN
D
P
Q
TE
I
I
V
LISKPPAPAVARK
V
LERA
R
AC
R
KPVVA
C
FLG
RG
E
TPVDEQ
G
L
Q
FA
RGSK
EAA
LK
AV
M
L
---
SGVKQEHLDLHTLNQ
P
LIA
DV
RA
RL
QPQQKY
IRGLF
C
GGTLC
D
E
T
LF
A
V
MEKH
G
-D
V
Y
SN
IQP
D
PEFR
L
QD
I
NR
S
IK
HT
F
LD
F
GDDDFT
N
GKPHPMIDPT
N
R
I
S
R
V
I
E
E
AR
DP
E
VAV
I
V
M
D
F
VLGFG
S
HE
DP
V
G
S
T
I
E
A
IK
E
A
K
A
I
A
AA
E
G
R
E
L
II
L
A
Y
V
L
GT
D
L
D
TP
S
LE
QQ
S
QM
L
L
DAGVI
L
ASS
STN
T
G
LLA
REF
ICKGEEA
fig|656417.3.peg.464
Escherichia coli M605
MSVKIVIK
P
N
T
Y
F
DSVSLM
S
IS
T
R
A
N
KL
D
GV
E
QA
F
V
A
M
A
T
E
M
NK
GV
L
KNL
GL
LTPELE
Q
A
K
NG
DL
M
I
V
I
N
G
K
SGVD
NE
Q
L
LA
E
I
EE
L
FN
T
K
A
Q
----
SG
SH
E
A
R
YG
T
----
IA
SA
K
K
HI
PE
S
NLA
V
ISV
N
G
L
F
AA
R
EA
R
QAL
QND
LNVM
L
FSDNVS
V
EDE
LA
LK
Q
LA
H
EKGLL
M
MGPDCGTAIING
A
A
L
C
F
G
N
A
V
R
RGNIG
IV
GASGTG
S
QEL
SV
RI
HEF
G
G
G
V
SQ
L
IGTGGRDLSE
K
IGG
LM
ML
D
A
I
S
ML
EN
D
P
Q
TE
I
I
V
LISKPPAPAVARK
V
LERA
R
AC
R
KPVVA
C
FLG
RG
E
TPVDEQ
G
L
Q
FA
RGSK
EAA
LK
AV
M
L
---
SGVKQEHLDLHTLNQ
P
LIA
DV
RA
RL
QPQQKY
IRGLF
C
GGTLC
D
E
T
LF
A
V
MEKH
G
-D
V
Y
SN
IQP
D
PEFR
L
QD
I
NR
S
IK
HT
F
LD
F
GDDDFT
N
GKPHPMIDPT
N
R
I
S
RL
I
E
E
AR
DP
E
VAV
I
V
M
D
F
VLGFG
S
HE
DP
V
G
S
T
I
E
A
IK
E
A
K
A
I
A
AA
E
G
R
E
L
II
L
A
Y
V
L
GT
D
L
D
TP
S
LE
QQ
S
QM
L
L
DAGVI
L
ASS
STN
T
G
LLA
REF
ICKGEEA
fig|753642.3.peg.1303
Escherichia coli NC101
MSVKIVIK
P
N
T
Y
F
DSVSLM
S
IS
T
R
A
N
KL
D
GV
E
QA
F
V
A
M
A
T
E
M
NK
GV
L
KNL
GL
LTPELE
Q
A
K
NG
DL
M
I
V
I
N
G
K
SGVD
NE
Q
L
LA
E
I
EE
L
FN
T
K
A
Q
----
SG
SH
E
A
R
YG
T
----
IA
SA
K
K
HI
PE
S
NLA
V
ISV
N
G
L
F
AA
R
EA
R
QAL
QND
LNVM
L
FSDNVS
V
EDE
LA
LK
Q
LA
H
EKGLL
M
MGPDCGTAIING
A
A
L
C
F
G
N
A
V
R
RGNIG
IV
GASGTG
S
QEL
SV
RI
YEF
G
G
G
V
SQ
L
IGTGGRDLSE
K
IGG
LM
ML
D
A
I
G
ML
EN
D
P
Q
TE
I
I
V
LISKPPAPAVARK
V
LERA
R
AC
R
KPVVA
C
FLG
RG
E
TPVDEQ
G
L
Q
FA
RGSK
EAA
LK
AV
M
L
---
SGVKQEHLDLHTLNQ
P
LIA
DV
RA
RL
QPQQKY
IRGLF
C
GGTLC
D
E
T
LF
A
V
MEKH
G
-D
V
Y
SN
IQP
D
PEFR
L
QD
I
NR
S
IK
HT
F
LD
F
GDDDFT
N
GKPHPMIDPT
N
R
I
S
RL
I
E
E
AR
DP
E
VAV
I
V
M
D
F
VLGFG
S
HE
DP
V
G
S
T
I
E
A
IK
E
A
K
A
I
A
AA
E
G
R
E
L
II
L
A
Y
V
L
GT
D
L
D
TP
S
LE
QQ
S
QM
L
L
DAGVI
L
ASS
STN
T
G
LLA
REF
ICKGEEA
fig|656440.3.peg.204
Escherichia coli TA206
MSVKIVIK
P
N
T
Y
F
DSVSLM
S
IS
T
R
A
N
KL
D
GV
E
QA
F
V
A
M
A
T
E
M
NK
GV
L
KNL
GL
LTPELE
Q
A
K
NG
DL
M
I
V
I
N
G
K
SGVD
NE
Q
L
LA
E
I
EE
L
FN
T
K
A
Q
----
SG
SH
E
A
R
YG
T
----
IA
SA
K
K
HI
PE
S
NLA
V
ISV
N
G
L
F
AA
R
EA
R
QAL
QND
LNVM
L
FSDNVS
V
EDE
LA
LK
Q
LA
H
EKGLL
M
MGPDCGTAIING
A
A
L
C
F
G
N
A
V
R
RGNIG
IV
GASGTG
S
QEL
SV
RI
YEF
G
G
G
V
SQ
L
IGTGGRDLSE
K
IGG
LM
ML
D
A
I
G
ML
EN
D
P
Q
TE
I
I
V
LISKPPAPAVARK
V
LERA
R
AC
R
KPVVA
C
FLG
RG
E
TPVDEQ
G
L
Q
FA
RGSK
EAA
LK
AV
M
L
---
SGVKQEHLDLHTLNQ
P
LIA
DV
RA
RL
QPQQKY
IRGLF
C
GGTLC
D
E
T
LF
A
V
MEKH
G
-D
V
Y
SN
IQP
D
PEFR
L
QD
I
NR
S
IK
HT
F
LD
F
GDDDFT
N
GKPHPMIDPT
N
R
I
S
RL
I
E
E
AR
DP
E
VAV
I
V
M
D
F
VLGFG
S
HE
DP
V
G
S
T
I
E
A
IK
E
A
K
A
I
A
AA
E
G
R
E
L
II
L
A
Y
V
L
GT
D
L
D
TP
S
LE
QQ
S
QM
L
L
DAGVI
L
ASS
STN
T
G
LLA
REF
ICKGEEA
fig|670897.3.peg.383
Escherichia coli 2362-75
MSVKIVIK
P
N
T
Y
F
DSVSLM
S
IS
T
R
A
N
KL
D
GV
E
QA
F
V
A
M
A
T
E
M
NK
GV
L
KNL
GL
LTPELE
Q
A
K
NG
DL
M
I
V
I
N
G
K
SGVD
NE
Q
L
LA
E
I
EE
L
FN
T
K
A
Q
----
SG
SH
E
A
R
YA
T
----
IA
SA
K
K
HI
PE
S
NLA
V
ISV
N
G
L
F
AA
R
EA
R
QAL
QND
LNVM
L
FSDNVS
V
EDE
LA
LK
Q
LA
H
EKGLL
M
MGPDCGTAIING
T
A
L
C
F
G
N
A
V
R
RGNIG
IV
GASGTG
S
QEL
SV
RI
YEF
G
G
G
V
SQ
L
IGTGGRDLSE
K
IGG
LM
ML
D
A
I
G
ML
EN
D
P
Q
TE
I
I
V
LISKPPAPAVARK
V
LERA
R
AC
R
KPVVA
C
FLG
RG
E
TPVDEQ
G
L
Q
FA
RGSK
EAA
LK
AV
M
L
---
SGVKQEHLDLHTLNQ
P
LIA
DV
RA
RL
QPQQKY
IRGLF
C
GGTLC
D
E
T
LF
A
V
MEKH
G
-D
V
Y
SN
IQP
D
PEFR
L
QD
I
NR
S
IK
HT
F
LD
F
GDDDFT
N
GKPHPMIDPT
N
R
I
S
RL
I
E
E
AR
DP
E
VAV
I
V
M
D
F
VLGFG
S
HE
DP
V
G
S
T
I
E
A
IK
E
A
K
A
I
A
AA
E
G
R
E
L
II
L
A
Y
V
L
GT
D
L
D
TP
S
LE
QQ
S
QM
L
L
DAGVI
L
ASS
STN
T
G
LLA
REF
ICKGEEA
fig|525281.3.peg.2573
Escherichia coli 83972
MSVKIVIK
P
N
T
Y
F
DSVSLM
S
IS
T
R
A
N
KL
D
GV
E
QA
F
V
A
M
A
T
E
M
NK
GV
L
KNL
GL
LTPELE
Q
A
K
NG
DL
M
I
V
I
N
G
K
SGVD
NE
Q
L
LA
E
I
EE
L
FN
T
K
A
Q
----
SG
SH
E
A
R
YA
T
----
IA
SA
K
K
YI
PE
S
NLA
V
ISV
N
G
L
F
AA
R
EA
R
QAL
QND
LNVM
L
FSDNVS
V
EDE
LA
LK
Q
LA
H
EKGLL
M
MGPDCGTAIING
A
A
L
C
F
G
N
A
V
R
RGNIG
IV
GASGTG
S
QEL
SV
RI
YEF
G
G
G
V
SQ
L
IGTGGRDLSE
K
IGG
LM
ML
D
A
I
G
ML
EN
D
P
Q
TE
I
I
V
LISKPPAPAVARK
V
LERA
R
AC
R
KPVVA
C
FLG
RG
E
TPVDEQ
G
L
Q
FA
RGSK
EAA
LK
AV
M
L
---
SGVKQEHLDLHTLNQ
P
LIA
DV
RA
RL
QPQQKY
IRGLF
C
GGTLC
D
E
T
LF
A
V
MEKH
G
-D
V
Y
SN
IQP
D
PEFR
L
QD
I
NR
S
IK
HT
F
LD
F
GDDDFT
N
GKPHPMIDPT
N
R
I
S
RL
I
E
E
AR
DP
E
VAV
I
V
M
D
F
VLGFG
S
HE
DP
V
G
S
T
I
E
A
IK
E
A
K
A
I
A
AA
E
G
R
E
L
II
L
A
Y
V
L
GT
D
L
D
TP
S
LE
QQ
S
QM
L
L
DAGVI
L
ASS
STN
T
G
LLA
REF
ICKGEEA
fig|655817.3.peg.446
Escherichia coli ABU 83972
MSVKIVIK
P
N
T
Y
F
DSVSLM
S
IS
T
R
A
N
KL
D
GV
E
QA
F
V
A
M
A
T
E
M
NK
GV
L
KNL
GL
LTPELE
Q
A
K
NG
DL
M
I
V
I
N
G
K
SGVD
NE
Q
L
LA
E
I
EE
L
FN
T
K
A
Q
----
SG
SH
E
A
R
YA
T
----
IA
SA
K
K
YI
PE
S
NLA
V
ISV
N
G
L
F
AA
R
EA
R
QAL
QND
LNVM
L
FSDNVS
V
EDE
LA
LK
Q
LA
H
EKGLL
M
MGPDCGTAIING
A
A
L
C
F
G
N
A
V
R
RGNIG
IV
GASGTG
S
QEL
SV
RI
YEF
G
G
G
V
SQ
L
IGTGGRDLSE
K
IGG
LM
ML
D
A
I
G
ML
EN
D
P
Q
TE
I
I
V
LISKPPAPAVARK
V
LERA
R
AC
R
KPVVA
C
FLG
RG
E
TPVDEQ
G
L
Q
FA
RGSK
EAA
LK
AV
M
L
---
SGVKQEHLDLHTLNQ
P
LIA
DV
RA
RL
QPQQKY
IRGLF
C
GGTLC
D
E
T
LF
A
V
MEKH
G
-D
V
Y
SN
IQP
D
PEFR
L
QD
I
NR
S
IK
HT
F
LD
F
GDDDFT
N
GKPHPMIDPT
N
R
I
S
RL
I
E
E
AR
DP
E
VAV
I
V
M
D
F
VLGFG
S
HE
DP
V
G
S
T
I
E
A
IK
E
A
K
A
I
A
AA
E
G
R
E
L
II
L
A
Y
V
L
GT
D
L
D
TP
S
LE
QQ
S
QM
L
L
DAGVI
L
ASS
STN
T
G
LLA
REF
ICKGEEA
fig|199310.1.peg.422
Escherichia coli CFT073
MSVKIVIK
P
N
T
Y
F
DSVSLM
S
IS
T
R
A
N
KL
D
GV
E
QA
F
V
A
M
A
T
E
M
NK
GV
L
KNL
GL
LTPELE
Q
A
K
NG
DL
M
I
V
I
N
G
K
SGVD
NE
Q
L
LA
E
I
EE
L
FN
T
K
A
Q
----
SG
SH
E
A
R
YA
T
----
IA
SA
K
K
YI
PE
S
NLA
V
ISV
N
G
L
F
AA
R
EA
R
QAL
QND
LNVM
L
FSDNVS
V
EDE
LA
LK
Q
LA
H
EKGLL
M
MGPDCGTAIING
A
A
L
C
F
G
N
A
V
R
RGNIG
IV
GASGTG
S
QEL
SV
RI
YEF
G
G
G
V
SQ
L
IGTGGRDLSE
K
IGG
LM
ML
D
A
I
G
ML
EN
D
P
Q
TE
I
I
V
LISKPPAPAVARK
V
LERA
R
AC
R
KPVVA
C
FLG
RG
E
TPVDEQ
G
L
Q
FA
RGSK
EAA
LK
AV
M
L
---
SGVKQEHLDLHTLNQ
P
LIA
DV
RA
RL
QPQQKY
IRGLF
C
GGTLC
D
E
T
LF
A
V
MEKH
G
-D
V
Y
SN
IQP
D
PEFR
L
QD
I
NR
S
IK
HT
F
LD
F
GDDDFT
N
GKPHPMIDPT
N
R
I
S
RL
I
E
E
AR
DP
E
VAV
I
V
M
D
F
VLGFG
S
HE
DP
V
G
S
T
I
E
A
IK
E
A
K
A
I
A
AA
E
G
R
E
L
II
L
A
Y
V
L
GT
D
L
D
TP
S
LE
QQ
S
QM
L
L
DAGVI
L
ASS
STN
T
G
LLA
REF
ICKGEEA
fig|199310.4.peg.413
Escherichia coli CFT073
MSVKIVIK
P
N
T
Y
F
DSVSLM
S
IS
T
R
A
N
KL
D
GV
E
QA
F
V
A
M
A
T
E
M
NK
GV
L
KNL
GL
LTPELE
Q
A
K
NG
DL
M
I
V
I
N
G
K
SGVD
NE
Q
L
LA
E
I
EE
L
FN
T
K
A
Q
----
SG
SH
E
A
R
YA
T
----
IA
SA
K
K
YI
PE
S
NLA
V
ISV
N
G
L
F
AA
R
EA
R
QAL
QND
LNVM
L
FSDNVS
V
EDE
LA
LK
Q
LA
H
EKGLL
M
MGPDCGTAIING
A
A
L
C
F
G
N
A
V
R
RGNIG
IV
GASGTG
S
QEL
SV
RI
YEF
G
G
G
V
SQ
L
IGTGGRDLSE
K
IGG
LM
ML
D
A
I
G
ML
EN
D
P
Q
TE
I
I
V
LISKPPAPAVARK
V
LERA
R
AC
R
KPVVA
C
FLG
RG
E
TPVDEQ
G
L
Q
FA
RGSK
EAA
LK
AV
M
L
---
SGVKQEHLDLHTLNQ
P
LIA
DV
RA
RL
QPQQKY
IRGLF
C
GGTLC
D
E
T
LF
A
V
MEKH
G
-D
V
Y
SN
IQP
D
PEFR
L
QD
I
NR
S
IK
HT
F
LD
F
GDDDFT
N
GKPHPMIDPT
N
R
I
S
RL
I
E
E
AR
DP
E
VAV
I
V
M
D
F
VLGFG
S
HE
DP
V
G
S
T
I
E
A
IK
E
A
K
A
I
A
AA
E
G
R
E
L
II
L
A
Y
V
L
GT
D
L
D
TP
S
LE
QQ
S
QM
L
L
DAGVI
L
ASS
STN
T
G
LLA
REF
ICKGEEA
fig|749546.3.peg.86
Escherichia coli MS 185-1
MSVKIVIK
P
N
T
Y
F
DSVSLM
S
IS
T
R
A
N
KL
D
GV
E
QA
F
V
A
M
A
T
E
M
NK
GV
L
KNL
GL
LTPELE
Q
A
K
NG
DL
M
I
V
I
N
G
K
SGVD
NE
Q
L
LA
E
I
EE
L
FN
T
K
A
Q
----
SG
SH
E
A
R
YA
T
----
IA
SA
K
K
YI
PE
S
NLA
V
ISV
N
G
L
F
AA
R
EA
R
QAL
QND
LNVM
L
FSDNVS
V
EDE
LA
LK
Q
LA
H
EKGLL
M
MGPDCGTAIING
A
A
L
C
F
G
N
A
V
R
RGNIG
IV
GASGTG
S
QEL
SV
RI
YEF
G
G
G
V
SQ
L
IGTGGRDLSE
K
IGG
LM
ML
D
A
I
G
ML
EN
D
P
Q
TE
I
I
V
LISKPPAPAVARK
V
LERA
R
AC
R
KPVVA
C
FLG
RG
E
TPVDEQ
G
L
Q
FA
RGSK
EAA
LK
AV
M
L
---
SGVKQEHLDLHTLNQ
P
LIA
DV
RA
RL
QPQQKY
IRGLF
C
GGTLC
D
E
T
LF
A
V
MEKH
G
-D
V
Y
SN
IQP
D
PEFR
L
QD
I
NR
S
IK
HT
F
LD
F
GDDDFT
N
GKPHPMIDPT
N
R
I
S
RL
I
E
E
AR
DP
E
VAV
I
V
M
D
F
VLGFG
S
HE
DP
V
G
S
T
I
E
A
IK
E
A
K
A
I
A
AA
E
G
R
E
L
II
L
A
Y
V
L
GT
D
L
D
TP
S
LE
QQ
S
QM
L
L
DAGVI
L
ASS
STN
T
G
LLA
REF
ICKGEEA
fig|749528.3.peg.1370
Escherichia coli MS 45-1
MSVKIVIK
P
N
T
Y
F
DSVSLM
S
IS
T
R
A
N
KL
D
GV
E
QA
F
V
A
M
A
T
E
M
NK
GV
L
KNL
GL
LTPELE
Q
A
K
NG
DL
M
I
V
I
N
G
K
SGVD
NE
Q
L
LA
E
I
EE
L
FN
T
K
A
Q
----
SG
SH
E
A
R
YA
T
----
IA
SA
K
K
YI
PE
S
NLA
V
ISV
N
G
L
F
AA
R
EA
R
QAL
QND
LNVM
L
FSDNVS
V
EDE
LA
LK
Q
LA
H
EKGLL
M
MGPDCGTAIING
A
A
L
C
F
G
N
A
V
R
RGNIG
IV
GASGTG
S
QEL
SV
RI
YEF
G
G
G
V
SQ
L
IGTGGRDLSE
K
IGG
LM
ML
D
A
I
G
ML
EN
D
P
Q
TE
I
I
V
LISKPPAPAVARK
V
LERA
R
AC
R
KPVVA
C
FLG
RG
E
TPVDEQ
G
L
Q
FA
RGSK
EAA
LK
AV
M
L
---
SGVKQEHLDLHTLNQ
P
LIA
DV
RA
RL
QPQQKY
IRGLF
C
GGTLC
D
E
T
LF
A
V
MEKH
G
-D
V
Y
SN
IQP
D
PEFR
L
QD
I
NR
S
IK
HT
F
LD
F
GDDDFT
N
GKPHPMIDPT
N
R
I
S
RL
I
E
E
AR
DP
E
VAV
I
V
M
D
F
VLGFG
S
HE
DP
V
G
S
T
I
E
A
IK
E
A
K
A
I
A
AA
E
G
R
E
L
II
L
A
Y
V
L
GT
D
L
D
TP
S
LE
QQ
S
QM
L
L
DAGVI
L
ASS
STN
T
G
LLA
REF
ICKGEEA
fig|362663.8.peg.391
Escherichia coli 536
MSVKIVIK
P
N
T
Y
F
DSVSLM
S
IS
T
R
A
N
KL
D
GV
E
QA
F
V
A
M
A
T
E
M
NK
GV
L
KNL
GL
LTPELE
Q
A
K
NG
DL
M
I
V
I
N
G
K
SGVD
NE
Q
L
LA
E
I
EE
L
FN
T
K
A
Q
----
SG
SH
E
A
R
YA
T
----
IA
SA
K
K
YI
PE
S
NLA
V
ISV
N
G
L
F
AA
R
EA
R
QAL
QND
LNVM
L
FSDNVS
V
EDE
LA
LK
Q
LA
H
EKGLL
M
MGPDCGTAIING
A
A
L
C
F
G
N
A
V
R
RGNIG
IV
GASGTG
S
QEL
SV
RI
HEF
G
G
G
V
SQ
L
IGTGGRDLSE
K
IGG
LM
ML
D
A
I
G
ML
EN
D
P
Q
TE
I
I
V
LISKPPAPAVARK
V
LERA
R
AC
R
KPVVA
C
FLG
RG
E
TSVDEQ
G
L
Q
FA
RGSK
EAA
LK
AV
M
L
---
SGVKQEHLDLHTLNQ
P
LIA
DV
RA
RL
QPQQKY
IRGLF
C
GGTLC
D
E
T
LF
A
V
MEKH
G
-D
V
Y
SN
IQP
D
PEFR
L
QD
I
NR
S
IK
HT
F
LD
F
GDDDFT
N
GKPHPMIDPT
N
R
I
S
RL
I
E
E
AR
DP
E
VAV
I
V
M
D
F
VLGFG
S
HE
DP
V
G
S
T
I
E
A
IK
E
A
K
A
I
A
AA
E
G
R
E
L
II
L
A
Y
V
L
GT
D
L
D
TP
S
LE
QQ
S
QM
L
L
DAGVI
L
ASS
STN
T
G
LLA
REF
ICKGEEA
fig|362663.9.peg.390
Escherichia coli 536
MSVKIVIK
P
N
T
Y
F
DSVSLM
S
IS
T
R
A
N
KL
D
GV
E
QA
F
V
A
M
A
T
E
M
NK
GV
L
KNL
GL
LTPELE
Q
A
K
NG
DL
M
I
V
I
N
G
K
SGVD
NE
Q
L
LA
E
I
EE
L
FN
T
K
A
Q
----
SG
SH
E
A
R
YA
T
----
IA
SA
K
K
YI
PE
S
NLA
V
ISV
N
G
L
F
AA
R
EA
R
QAL
QND
LNVM
L
FSDNVS
V
EDE
LA
LK
Q
LA
H
EKGLL
M
MGPDCGTAIING
A
A
L
C
F
G
N
A
V
R
RGNIG
IV
GASGTG
S
QEL
SV
RI
HEF
G
G
G
V
SQ
L
IGTGGRDLSE
K
IGG
LM
ML
D
A
I
G
ML
EN
D
P
Q
TE
I
I
V
LISKPPAPAVARK
V
LERA
R
AC
R
KPVVA
C
FLG
RG
E
TSVDEQ
G
L
Q
FA
RGSK
EAA
LK
AV
M
L
---
SGVKQEHLDLHTLNQ
P
LIA
DV
RA
RL
QPQQKY
IRGLF
C
GGTLC
D
E
T
LF
A
V
MEKH
G
-D
V
Y
SN
IQP
D
PEFR
L
QD
I
NR
S
IK
HT
F
LD
F
GDDDFT
N
GKPHPMIDPT
N
R
I
S
RL
I
E
E
AR
DP
E
VAV
I
V
M
D
F
VLGFG
S
HE
DP
V
G
S
T
I
E
A
IK
E
A
K
A
I
A
AA
E
G
R
E
L
II
L
A
Y
V
L
GT
D
L
D
TP
S
LE
QQ
S
QM
L
L
DAGVI
L
ASS
STN
T
G
LLA
REF
ICKGEEA
fig|340197.3.peg.3681
Escherichia coli F11
MSVKIVIK
P
N
T
Y
F
DSVSLM
S
IS
T
R
A
N
KL
D
GV
E
QA
F
V
A
M
A
T
E
M
NK
GV
L
KNL
GL
LTPELE
Q
A
K
NG
DL
M
I
V
I
N
G
K
SGVD
NE
Q
L
LA
E
I
EE
L
FN
T
K
A
Q
----
SG
SH
E
A
R
YA
T
----
IA
SA
K
K
YI
PE
S
NLA
V
ISV
N
G
L
F
AA
R
EA
R
QAL
QND
LNVM
L
FSDNVS
V
EDE
LA
LK
Q
LA
H
EKGLL
M
MGPDCGTAIING
A
A
L
C
F
G
N
A
V
R
RGNIG
IV
GASGTG
S
QEL
SV
RI
HEF
G
G
G
V
SQ
L
IGTGGRDLSE
K
IGG
LM
ML
D
A
I
G
ML
EN
D
P
Q
TE
I
I
V
LISKPPAPAVARK
V
LERA
R
AC
R
KPVVA
C
FLG
RG
E
TSVDEQ
G
L
Q
FA
RGSK
EAA
LK
AV
M
L
---
SGVKQEHLDLHTLNQ
P
LIA
DV
RA
RL
QPQQKY
IRGLF
C
GGTLC
D
E
T
LF
A
V
MEKH
G
-D
V
Y
SN
IQP
D
PEFR
L
QD
I
NR
S
IK
HT
F
LD
F
GDDDFT
N
GKPHPMIDPT
N
R
I
S
RL
I
E
E
AR
DP
E
VAV
I
V
M
D
F
VLGFG
S
HE
DP
V
G
S
T
I
E
A
IK
E
A
K
A
I
A
AA
E
G
R
E
L
II
L
A
Y
V
L
GT
D
L
D
TP
S
LE
QQ
S
QM
L
L
DAGVI
L
ASS
STN
T
G
LLA
REF
ICKGEEA
fig|340197.5.peg.3848
Escherichia coli F11
MSVKIVIK
P
N
T
Y
F
DSVSLM
S
IS
T
R
A
N
KL
D
GV
E
QA
F
V
A
M
A
T
E
M
NK
GV
L
KNL
GL
LTPELE
Q
A
K
NG
DL
M
I
V
I
N
G
K
SGVD
NE
Q
L
LA
E
I
EE
L
FN
T
K
A
Q
----
SG
SH
E
A
R
YA
T
----
IA
SA
K
K
YI
PE
S
NLA
V
ISV
N
G
L
F
AA
R
EA
R
QAL
QND
LNVM
L
FSDNVS
V
EDE
LA
LK
Q
LA
H
EKGLL
M
MGPDCGTAIING
A
A
L
C
F
G
N
A
V
R
RGNIG
IV
GASGTG
S
QEL
SV
RI
HEF
G
G
G
V
SQ
L
IGTGGRDLSE
K
IGG
LM
ML
D
A
I
G
ML
EN
D
P
Q
TE
I
I
V
LISKPPAPAVARK
V
LERA
R
AC
R
KPVVA
C
FLG
RG
E
TSVDEQ
G
L
Q
FA
RGSK
EAA
LK
AV
M
L
---
SGVKQEHLDLHTLNQ
P
LIA
DV
RA
RL
QPQQKY
IRGLF
C
GGTLC
D
E
T
LF
A
V
MEKH
G
-D
V
Y
SN
IQP
D
PEFR
L
QD
I
NR
S
IK
HT
F
LD
F
GDDDFT
N
GKPHPMIDPT
N
R
I
S
RL
I
E
E
AR
DP
E
VAV
I
V
M
D
F
VLGFG
S
HE
DP
V
G
S
T
I
E
A
IK
E
A
K
A
I
A
AA
E
G
R
E
L
II
L
A
Y
V
L
GT
D
L
D
TP
S
LE
QQ
S
QM
L
L
DAGVI
L
ASS
STN
T
G
LLA
REF
ICKGEEA
fig|749550.3.peg.907
Escherichia coli MS 200-1
MSVKIVIK
P
N
T
Y
F
DSVSLM
S
IS
T
R
A
N
KL
D
GV
E
QA
F
V
A
M
A
T
E
M
NK
GV
L
KNL
GL
LTPELE
Q
A
K
NG
DL
M
I
V
I
N
G
K
SGVD
NE
Q
L
LA
E
I
EE
L
FN
T
K
A
Q
----
SG
SH
E
A
R
YA
T
----
IA
SA
K
K
YI
PE
S
NLA
V
ISV
N
G
L
F
AA
R
EA
R
QAL
QND
LNVM
L
FSDNVS
V
EDE
LA
LK
Q
LA
H
EKGLL
M
MGPDCGTAIING
A
A
L
C
F
G
N
A
V
R
RGNIG
IV
GASGTG
S
QEL
SV
RI
HEF
G
G
G
V
SQ
L
IGTGGRDLSE
K
IGG
LM
ML
D
A
I
G
ML
EN
D
P
Q
TE
I
I
V
LISKPPAPAVARK
V
LERA
R
AC
R
KPVVA
C
FLG
RG
E
TSVDEQ
G
L
Q
FA
RGSK
EAA
LK
AV
M
L
---
SGVKQEHLDLHTLNQ
P
LIA
DV
RA
RL
QPQQKY
IRGLF
C
GGTLC
D
E
T
LF
A
V
MEKH
G
-D
V
Y
SN
IQP
D
PEFR
L
QD
I
NR
S
IK
HT
F
LD
F
GDDDFT
N
GKPHPMIDPT
N
R
I
S
RL
I
E
E
AR
DP
E
VAV
I
V
M
D
F
VLGFG
S
HE
DP
V
G
S
T
I
E
A
IK
E
A
K
A
I
A
AA
E
G
R
E
L
II
L
A
Y
V
L
GT
D
L
D
TP
S
LE
QQ
S
QM
L
L
DAGVI
L
ASS
STN
T
G
LLA
REF
ICKGEEA
fig|431946.3.peg.306
Escherichia coli SE15
MSVKIVIK
P
N
T
Y
F
DSVSLM
S
IS
T
R
A
N
KL
D
GV
E
QA
F
V
A
M
A
T
E
M
NK
GV
L
KNL
GL
LTPELE
Q
A
K
NG
DL
M
I
V
I
N
G
K
SGVD
NE
Q
L
LA
E
I
EE
L
FN
T
K
A
Q
----
SG
SH
E
A
R
YG
T
----
IA
SA
K
K
HI
PE
S
NLA
V
ISV
N
G
L
F
AA
R
EA
R
QAL
QND
LNVM
L
FSDNVS
V
EDE
LA
LK
Q
LA
H
EKGLL
M
MGPDCGTAIING
A
A
L
C
F
G
N
A
V
R
RGNIG
IV
GASGTG
S
QEL
SV
RI
HEF
G
G
G
V
SQ
L
IGTGGRDLSE
K
IGG
LM
ML
D
A
I
S
ML
EN
D
P
Q
TE
I
I
V
LISKPPAPAVARK
V
LERA
R
AC
R
KPVVA
C
FLG
RG
E
TPVDEQ
G
L
Q
FA
RGSK
EAA
LK
AV
M
L
---
SGVKQEHLDLHTLDQ
P
LIA
DV
RA
RL
QPQQKY
IRGLF
C
GGTLC
D
E
T
LF
A
V
MEKH
G
-D
V
Y
SN
IQP
D
PEFR
L
QD
I
NR
S
IK
HT
F
LD
F
GDDDFT
N
GKPHPMIDPT
N
R
I
S
RL
I
E
E
AR
DP
E
VAV
I
V
M
D
F
VLGFG
S
HE
DP
V
G
S
T
I
E
A
IK
E
A
K
A
I
A
AA
E
G
R
E
L
II
L
A
Y
V
L
GT
D
L
D
TP
S
LE
QQ
S
QM
L
L
DAGVI
L
ASS
STN
T
G
LLA
REF
ICKGEEA
fig|216593.1.peg.3270
Escherichia coli E2348/69
MSVKIVIK
P
N
T
Y
F
DSVSLM
S
IS
T
R
A
N
KL
D
GV
E
QA
F
V
A
M
A
T
E
M
NK
GV
L
KNL
GL
LTPELE
Q
A
K
NG
DL
M
I
V
I
N
G
K
SGVD
NE
Q
L
LA
E
I
EE
L
FN
T
K
A
Q
----
SG
SH
E
A
R
YA
T
----
IA
SA
K
K
HI
PE
S
NLA
V
ISV
N
G
L
F
AA
R
EA
R
QAL
QND
LNVM
L
FSDNVS
V
EDE
LA
LK
Q
LA
H
EKGLL
M
MGPDCGTAIING
T
A
L
C
F
G
N
A
V
R
RGNIG
IV
GASGTG
S
QEL
SV
RI
YEF
G
G
G
V
SQ
L
IGTGGRDLSE
K
IGG
LM
ML
D
A
I
G
ML
EN
D
P
Q
TE
I
I
V
LISKPPAPAVARK
V
LERA
R
AC
R
KPVVA
C
FLG
RG
E
TPVDEQ
G
L
Q
FA
RGSK
EAA
LK
AV
M
L
---
SGVKQEHLDLHTLNQ
P
LIA
DV
RA
RL
QSQQKY
IRGLF
C
GGTLC
D
E
T
LF
A
V
MEKH
G
-D
V
Y
SN
IQP
D
PEFR
L
QD
I
NR
S
IK
HT
F
LD
F
GDDDFT
N
GKPHPMIDPT
N
R
I
S
RL
I
E
E
AR
DP
E
VAV
I
V
M
D
F
VLGFG
S
HE
DP
V
G
S
T
I
E
A
IK
E
A
K
A
I
A
AA
E
G
R
E
L
II
L
A
Y
V
L
GT
D
L
D
TP
S
LE
QQ
S
QM
L
L
DAGVI
L
ASS
STN
T
G
LLA
REF
ICKGEEA
fig|574521.7.peg.297
Escherichia coli O127:H6 str. E2348/69
MSVKIVIK
P
N
T
Y
F
DSVSLM
S
IS
T
R
A
N
KL
D
GV
E
QA
F
V
A
M
A
T
E
M
NK
GV
L
KNL
GL
LTPELE
Q
A
K
NG
DL
M
I
V
I
N
G
K
SGVD
NE
Q
L
LA
E
I
EE
L
FN
T
K
A
Q
----
SG
SH
E
A
R
YA
T
----
IA
SA
K
K
HI
PE
S
NLA
V
ISV
N
G
L
F
AA
R
EA
R
QAL
QND
LNVM
L
FSDNVS
V
EDE
LA
LK
Q
LA
H
EKGLL
M
MGPDCGTAIING
T
A
L
C
F
G
N
A
V
R
RGNIG
IV
GASGTG
S
QEL
SV
RI
YEF
G
G
G
V
SQ
L
IGTGGRDLSE
K
IGG
LM
ML
D
A
I
G
ML
EN
D
P
Q
TE
I
I
V
LISKPPAPAVARK
V
LERA
R
AC
R
KPVVA
C
FLG
RG
E
TPVDEQ
G
L
Q
FA
RGSK
EAA
LK
AV
M
L
---
SGVKQEHLDLHTLNQ
P
LIA
DV
RA
RL
QSQQKY
IRGLF
C
GGTLC
D
E
T
LF
A
V
MEKH
G
-D
V
Y
SN
IQP
D
PEFR
L
QD
I
NR
S
IK
HT
F
LD
F
GDDDFT
N
GKPHPMIDPT
N
R
I
S
RL
I
E
E
AR
DP
E
VAV
I
V
M
D
F
VLGFG
S
HE
DP
V
G
S
T
I
E
A
IK
E
A
K
A
I
A
AA
E
G
R
E
L
II
L
A
Y
V
L
GT
D
L
D
TP
S
LE
QQ
S
QM
L
L
DAGVI
L
ASS
STN
T
G
LLA
REF
ICKGEEA
fig|585397.7.peg.4516
Escherichia coli ED1a (1-504/519)
M
K
VK
YKVF
S
N
L
YQDSVSLM
Q
IS
A
Q
I
SKL
P
G
I
Q
QASV
V
MGTP
N
N
L
EQ
L
RDA
GL
GNE--I
NA
S
PNDL
V
IA
V
M
GE
EDIC
NEAL
VL
-
A
QQ
R
LT
S
K
P
D
DETD
SG
IK
S
P
E
KV
S
----
LE
M
A
L
E
AE
PEANLALISV
P
G
D
YAA
A
EA
I
K
AL
NLG
M
NVMMFSDNVS
I
GQ
E
KS
I
KTLARE
RQRI
VMGPDCGTAI
V
NG
I
PL
G
FANVV
K
RG
A
IGVIGASGTG
L
QE
V
TC
RI
DQL
G
A
GISQA
L
GTGG
H
DLSEEIGGISML
F
AL
D
A
L
AQ
D
D
E
T
R
VI
V
LISKPP
S
P
I
VAR
T
ILERA
E
ACGKPVV
V
N
FLG
AN
P
HDLARP
N
I
T
A
A
TTLA
S
AA
NI
AV
A
L
LND
QPLPAVETEISCADL
T
MLQ
NA
CQ
RL
PAHRQA
IRG
V
F
A
GGT
F
C
Y
EA
Q-
L
I
CQQK
G
FS
A
A
SN
TPV
A
GNSA
L
AN
I
WQ
S
ED
HT
L
I
D
M
GDDDFT
R
GKPHPMIDPTLRN
Q
RL
L
N
E
LN
D
S
H
T
AV
V
L
F
D
L
VLG
Y
GA
ST
T
PA
S
E
L
L
-
-
-D
Q
L
S
H
-
I
DM
N
N
A
PL
-L
IA
H
V
C
GTE
A
DPQ
I
RSQQI
RA
L
Q
N
AGVI
I
ASS
NAQ
A
A
L
W
A
fig|585397.9.peg.4513
Escherichia coli ED1a (1-504/519)
M
K
VK
YKVF
S
N
L
YQDSVSLM
Q
IS
A
Q
I
SKL
P
G
I
Q
QASV
V
MGTP
N
N
L
EQ
L
RDA
GL
GNE--I
NA
S
PNDL
V
IA
V
M
GE
EDIC
NEAL
VL
-
A
QQ
R
LT
S
K
P
D
DETD
SG
IK
S
P
E
KV
S
----
LE
M
A
L
E
AE
PEANLALISV
P
G
D
YAA
A
EA
I
K
AL
NLG
M
NVMMFSDNVS
I
GQ
E
KS
I
KTLARE
RQRI
VMGPDCGTAI
V
NG
I
PL
G
FANVV
K
RG
A
IGVIGASGTG
L
QE
V
TC
RI
DQL
G
A
GISQA
L
GTGG
H
DLSEEIGGISML
F
AL
D
A
L
AQ
D
D
E
T
R
VI
V
LISKPP
S
P
I
VAR
T
ILERA
E
ACGKPVV
V
N
FLG
AN
P
HDLARP
N
I
T
A
A
TTLA
S
AA
NI
AV
A
L
LND
QPLPAVETEISCADL
T
MLQ
NA
CQ
RL
PAHRQA
IRG
V
F
A
GGT
F
C
Y
EA
Q-
L
I
CQQK
G
FS
A
A
SN
TPV
A
GNSA
L
AN
I
WQ
S
ED
HT
L
I
D
M
GDDDFT
R
GKPHPMIDPTLRN
Q
RL
L
N
E
LN
D
S
H
T
AV
V
L
F
D
L
VLG
Y
GA
ST
T
PA
S
E
L
L
-
-
-D
Q
L
S
H
-
I
DM
N
N
A
PL
-L
IA
H
V
C
GTE
A
DPQ
I
RSQQI
RA
L
Q
N
AGVI
I
ASS
NAQ
A
A
L
W
A
fig|753642.3.peg.3336
Escherichia coli NC101 (1-504/519)
M
K
VK
YKVF
S
N
L
YQDSVSLM
Q
IS
A
Q
I
SKL
P
G
I
Q
QASV
V
MGTP
N
N
L
EQ
L
RDA
GL
GNE--I
NA
S
PNDL
V
IA
V
M
GE
EDIC
NEAL
VL
-
A
QQ
R
LT
S
K
P
D
DETD
SG
IK
T
P
E
KV
S
----
LE
M
A
L
E
AE
PEANLALISV
P
G
D
YAA
A
EA
M
K
AL
NLG
M
NVMMFSDNVS
I
GQ
E
KS
I
KTLARE
RQRI
VMGPDCGTAI
V
NG
I
PL
G
FANVV
K
RG
A
IGVIGASGTG
L
QE
V
TC
RI
DQL
G
A
GISQA
L
GTGG
H
DLSEEIGGISML
F
AL
D
A
L
AQ
D
D
E
T
R
VI
V
LISKPP
S
P
I
VAR
T
ILERA
E
ACGKPVV
V
N
FLG
AN
P
HDLARP
N
I
T
A
A
TTLA
S
AA
NI
AV
A
L
LND
QPLPAVETEISCADL
T
MLQ
NA
CQ
RL
PAHRQA
IRG
V
F
A
GGT
F
C
Y
EA
Q-
L
I
CQQK
G
FS
A
A
SN
TPV
A
GNRA
L
AN
I
WQ
S
ED
HT
L
I
D
M
GDDDFT
R
GKPHPMIDPTLRN
Q
RL
L
N
E
LN
D
S
H
T
AV
V
L
F
D
L
VLG
Y
GA
ST
T
PA
S
E
L
L
-
-
-D
Q
L
S
H
-
I
DM
N
N
A
PL
-L
IA
H
V
C
GTE
A
DPQ
I
RSQQI
SA
L
Q
N
AGVI
I
ASS
NAQ
A
A
L
W
A
fig|656393.3.peg.5011
Escherichia coli H299 (1-504/519)
M
K
VK
YKVF
S
N
L
YQDSVSLM
Q
IS
A
Q
I
SKL
P
G
I
Q
QASV
V
MGTP
N
N
L
EQ
L
RDA
GL
GNE--I
NA
S
PNDL
V
IA
V
M
GE
EDIC
NEAL
IL
-
A
QQ
R
LT
S
K
P
D
DETG
SG
IK
T
P
E
KV
S
----
LE
M
A
L
E
AE
PEANLALISV
P
G
D
YAA
A
EA
I
K
AL
NLG
M
NVMMFSDNVS
I
A
Q
E
KS
I
KTLARE
RQRI
VMGPDCGTAI
V
NG
I
PL
G
FANVV
K
RG
A
IGVIGASGTG
L
QE
V
TC
RI
DQL
G
V
GISQA
L
GTGG
H
DLSEEIGGISML
F
AL
D
A
L
AQ
D
D
E
T
R
VI
V
LISKPP
S
P
I
VAR
T
ILERA
E
ACGKPVV
V
N
FLG
AN
P
HDLARP
N
I
T
A
A
TTLA
S
AA
DI
AV
A
L
LN
V
QPLPAVETDVPCDDL
T
MLQ
NA
CQ
RL
PAHRQA
IRG
V
F
A
GGT
F
C
Y
EA
Q-
L
I
CQQK
G
FS
A
A
SN
TPV
A
GNRA
L
AN
I
WQ
S
ED
HT
L
I
D
M
GDDDFT
R
GKPHPMIDPTLRN
Q
RL
L
N
E
LN
D
S
H
T
AV
V
L
F
D
L
VLG
Y
GA
ST
T
PA
S
E
L
L
-
-
-D
Q
L
S
H
-
I
DM
N
N
A
PL
-L
IA
H
V
C
GTE
A
DPQ
I
RSQQI
RA
L
Q
N
AGVI
I
ASS
NAQ
A
A
L
W
A
fig|656417.3.peg.4727
Escherichia coli M605 (1-504/519)
M
K
VK
YKVF
S
N
L
YQDSVSLM
Q
IS
A
Q
I
SKL
P
G
I
Q
QASV
V
MGTP
N
N
L
EQ
L
RDA
GL
GNE--I
NA
S
PNDL
V
IA
V
M
GE
EDIC
NEAL
VL
-
A
QQ
R
LT
S
K
P
D
DETD
SG
IK
T
P
E
KV
S
----
LE
M
A
L
E
AE
PEANLALISV
P
G
D
YAA
A
EA
I
K
AL
NLG
M
NVMMFSDNVS
I
GQ
E
KS
I
KTLARE
RQRI
VMGPDCGTAI
V
NG
I
PL
G
FANVV
K
RG
A
IGVIGASGTG
L
QE
V
TC
RI
DQL
G
A
GISQA
L
GTGG
H
DLSEEIGGISML
F
AL
D
A
L
AQ
D
D
E
T
R
VI
V
LISKPP
S
P
I
VAR
T
ILERA
E
ACGKPVV
V
N
FLG
AN
P
HDLARP
N
I
T
A
A
TTLA
S
AA
DI
AV
A
L
LN
A
QPLPAVETDVPCDDL
T
MLQ
NA
CQ
RL
PAHRQA
IRG
V
F
A
GGT
F
C
Y
EA
Q-
L
I
CQQK
G
FS
A
A
SN
TPV
A
GNRA
L
AN
I
WQ
S
ED
HT
L
I
D
M
GDDDFT
R
GKPHPMIDPTLRN
Q
RL
L
N
E
LN
D
S
H
T
AV
V
L
F
D
L
VLG
Y
GA
ST
T
PA
S
E
L
L
-
-
-D
Q
L
S
H
-
I
DM
N
N
A
PL
-L
IA
H
V
C
GTE
A
DPQ
I
RSQQI
SA
L
Q
N
AGVI
I
ASS
NAQ
A
A
L
W
A
fig|525281.3.peg.4837
Escherichia coli 83972 (1-504/519)
M
K
VK
YKVF
S
N
L
YQDSVSLM
Q
IS
A
Q
I
SKL
P
G
I
Q
QASV
V
MGTP
N
N
L
EQ
L
RDA
GL
GNE--I
NA
S
PNDL
V
IA
V
M
GE
EDIC
NEAL
VL
-
A
QQ
R
LT
S
K
P
D
DETD
SG
IK
T
P
E
KV
S
----
LE
M
A
L
E
AE
PEANLALISV
P
G
D
YAA
A
EA
M
K
AL
NLG
M
NVMMFSDNVS
I
GQ
E
KS
I
KTLARE
RQRI
VMGPDCGTAI
V
NG
I
PL
G
FANVV
K
RG
A
IGVIGASGTG
L
QE
V
TC
RI
DQL
G
A
GISQA
L
GTGG
H
DLSEEIGGISML
F
AL
D
A
L
AQ
D
D
E
T
R
VI
V
LISKPP
S
P
I
VAR
T
ILERA
E
ACGKPVV
V
N
FLG
AN
P
HDLARP
N
I
T
A
A
TTLA
S
AA
NI
AV
A
L
LND
QPLPAVETEISCDDL
T
MLQ
NA
CQ
RL
PAHRQA
IRG
V
F
A
GGT
F
C
Y
EA
Q-
L
I
CQQK
G
FS
A
A
SN
TPV
A
GNRA
L
AN
I
WQ
S
ED
HT
L
I
D
M
GDDDFT
R
GKPHPMIDPTLRN
Q
RL
L
N
E
LN
D
S
H
T
AV
V
L
F
D
L
VLG
Y
GA
ST
T
PA
S
E
L
L
-
-
-D
Q
L
S
H
-
I
DM
N
N
A
PL
-L
IA
H
V
C
GTE
A
DPQ
I
RSQQI
SA
L
Q
N
AGVI
I
ASS
NAQ
A
A
L
W
A
fig|655817.3.peg.4514
Escherichia coli ABU 83972 (1-504/519)
M
K
VK
YKVF
S
N
L
YQDSVSLM
Q
IS
A
Q
I
SKL
P
G
I
Q
QASV
V
MGTP
N
N
L
EQ
L
RDA
GL
GNE--I
NA
S
PNDL
V
IA
V
M
GE
EDIC
NEAL
VL
-
A
QQ
R
LT
S
K
P
D
DETD
SG
IK
T
P
E
KV
S
----
LE
M
A
L
E
AE
PEANLALISV
P
G
D
YAA
A
EA
M
K
AL
NLG
M
NVMMFSDNVS
I
GQ
E
KS
I
KTLARE
RQRI
VMGPDCGTAI
V
NG
I
PL
G
FANVV
K
RG
A
IGVIGASGTG
L
QE
V
TC
RI
DQL
G
A
GISQA
L
GTGG
H
DLSEEIGGISML
F
AL
D
A
L
AQ
D
D
E
T
R
VI
V
LISKPP
S
P
I
VAR
T
ILERA
E
ACGKPVV
V
N
FLG
AN
P
HDLARP
N
I
T
A
A
TTLA
S
AA
NI
AV
A
L
LND
QPLPAVETEISCDDL
T
MLQ
NA
CQ
RL
PAHRQA
IRG
V
F
A
GGT
F
C
Y
EA
Q-
L
I
CQQK
G
FS
A
A
SN
TPV
A
GNRA
L
AN
I
WQ
S
ED
HT
L
I
D
M
GDDDFT
R
GKPHPMIDPTLRN
Q
RL
L
N
E
LN
D
S
H
T
AV
V
L
F
D
L
VLG
Y
GA
ST
T
PA
S
E
L
L
-
-
-D
Q
L
S
H
-
I
DM
N
N
A
PL
-L
IA
H
V
C
GTE
A
DPQ
I
RSQQI
SA
L
Q
N
AGVI
I
ASS
NAQ
A
A
L
W
A
fig|199310.1.peg.4669
Escherichia coli CFT073 (1-504/519)
M
K
VK
YKVF
S
N
L
YQDSVSLM
Q
IS
A
Q
I
SKL
P
G
I
Q
QASV
V
MGTP
N
N
L
EQ
L
RDA
GL
GNE--I
NA
S
PNDL
V
IA
V
M
GE
EDIC
NEAL
VL
-
A
QQ
R
LT
S
K
P
D
DETD
SG
IK
T
P
E
KV
S
----
LE
M
A
L
E
AE
PEANLALISV
P
G
D
YAA
A
EA
M
K
AL
NLG
M
NVMMFSDNVS
I
GQ
E
KS
I
KTLARE
RQRI
VMGPDCGTAI
V
NG
I
PL
G
FANVV
K
RG
A
IGVIGASGTG
L
QE
V
TC
RI
DQL
G
A
GISQA
L
GTGG
H
DLSEEIGGISML
F
AL
D
A
L
AQ
D
D
E
T
R
VI
V
LISKPP
S
P
I
VAR
T
ILERA
E
ACGKPVV
V
N
FLG
AN
P
HDLARP
N
I
T
A
A
TTLA
S
AA
NI
AV
A
L
LND
QPLPAVETEISCDDL
T
MLQ
NA
CQ
RL
PAHRQA
IRG
V
F
A
GGT
F
C
Y
EA
Q-
L
I
CQQK
G
FS
A
A
SN
TPV
A
GNRA
L
AN
I
WQ
S
ED
HT
L
I
D
M
GDDDFT
R
GKPHPMIDPTLRN
Q
RL
L
N
E
LN
D
S
H
T
AV
V
L
F
D
L
VLG
Y
GA
ST
T
PA
S
E
L
L
-
-
-D
Q
L
S
H
-
I
DM
N
N
A
PL
-L
IA
H
V
C
GTE
A
DPQ
I
RSQQI
SA
L
Q
N
AGVI
I
ASS
NAQ
A
A
L
W
A
fig|199310.4.peg.4474
Escherichia coli CFT073 (1-504/519)
M
K
VK
YKVF
S
N
L
YQDSVSLM
Q
IS
A
Q
I
SKL
P
G
I
Q
QASV
V
MGTP
N
N
L
EQ
L
RDA
GL
GNE--I
NA
S
PNDL
V
IA
V
M
GE
EDIC
NEAL
VL
-
A
QQ
R
LT
S
K
P
D
DETD
SG
IK
T
P
E
KV
S
----
LE
M
A
L
E
AE
PEANLALISV
P
G
D
YAA
A
EA
M
K
AL
NLG
M
NVMMFSDNVS
I
GQ
E
KS
I
KTLARE
RQRI
VMGPDCGTAI
V
NG
I
PL
G
FANVV
K
RG
A
IGVIGASGTG
L
QE
V
TC
RI
DQL
G
A
GISQA
L
GTGG
H
DLSEEIGGISML
F
AL
D
A
L
AQ
D
D
E
T
R
VI
V
LISKPP
S
P
I
VAR
T
ILERA
E
ACGKPVV
V
N
FLG
AN
P
HDLARP
N
I
T
A
A
TTLA
S
AA
NI
AV
A
L
LND
QPLPAVETEISCDDL
T
MLQ
NA
CQ
RL
PAHRQA
IRG
V
F
A
GGT
F
C
Y
EA
Q-
L
I
CQQK
G
FS
A
A
SN
TPV
A
GNRA
L
AN
I
WQ
S
ED
HT
L
I
D
M
GDDDFT
R
GKPHPMIDPTLRN
Q
RL
L
N
E
LN
D
S
H
T
AV
V
L
F
D
L
VLG
Y
GA
ST
T
PA
S
E
L
L
-
-
-D
Q
L
S
H
-
I
DM
N
N
A
PL
-L
IA
H
V
C
GTE
A
DPQ
I
RSQQI
SA
L
Q
N
AGVI
I
ASS
NAQ
A
A
L
W
A
fig|749546.3.peg.1247
Escherichia coli MS 185-1 (1-504/519)
M
K
VK
YKVF
S
N
L
YQDSVSLM
Q
IS
A
Q
I
SKL
P
G
I
Q
QASV
V
MGTP
N
N
L
EQ
L
RDA
GL
GNE--I
NA
S
PNDL
V
IA
V
M
GE
EDIC
NEAL
VL
-
A
QQ
R
LT
S
K
P
D
DETD
SG
IK
T
P
E
KV
S
----
LE
M
A
L
E
AE
PEANLALISV
P
G
D
YAA
A
EA
M
K
AL
NLG
M
NVMMFSDNVS
I
GQ
E
KS
I
KTLARE
RQRI
VMGPDCGTAI
V
NG
I
PL
G
FANVV
K
RG
A
IGVIGASGTG
L
QE
V
TC
RI
DQL
G
A
GISQA
L
GTGG
H
DLSEEIGGISML
F
AL
D
A
L
AQ
D
D
E
T
R
VI
V
LISKPP
S
P
I
VAR
T
ILERA
E
ACGKPVV
V
N
FLG
AN
P
HDLARP
N
I
T
A
A
TTLA
S
AA
NI
AV
A
L
LND
QPLPAVETEISCDDL
T
MLQ
NA
CQ
RL
PAHRQA
IRG
V
F
A
GGT
F
C
Y
EA
Q-
L
I
CQQK
G
FS
A
A
SN
TPV
A
GNRA
L
AN
I
WQ
S
ED
HT
L
I
D
M
GDDDFT
R
GKPHPMIDPTLRN
Q
RL
L
N
E
LN
D
S
H
T
AV
V
L
F
D
L
VLG
Y
GA
ST
T
PA
S
E
L
L
-
-
-D
Q
L
S
H
-
I
DM
N
N
A
PL
-L
IA
H
V
C
GTE
A
DPQ
I
RSQQI
SA
L
Q
N
AGVI
I
ASS
NAQ
A
A
L
W
A
fig|749528.3.peg.3202
Escherichia coli MS 45-1 (1-504/519)
M
K
VK
YKVF
S
N
L
YQDSVSLM
Q
IS
A
Q
I
SKL
P
G
I
Q
QASV
V
MGTP
N
N
L
EQ
L
RDA
GL
GNE--I
NA
S
PNDL
V
IA
V
M
GE
EDIC
NEAL
VL
-
A
QQ
R
LT
S
K
P
D
DETD
SG
IK
T
P
E
KV
S
----
LE
M
A
L
E
AE
PEANLALISV
P
G
D
YAA
A
EA
M
K
AL
NLG
M
NVMMFSDNVS
I
GQ
E
KS
I
KTLARE
RQRI
VMGPDCGTAI
V
NG
I
PL
G
FANVV
K
RG
A
IGVIGASGTG
L
QE
V
TC
RI
DQL
G
A
GISQA
L
GTGG
H
DLSEEIGGISML
F
AL
D
A
L
AQ
D
D
E
T
R
VI
V
LISKPP
S
P
I
VAR
T
ILERA
E
ACGKPVV
V
N
FLG
AN
P
HDLARP
N
I
T
A
A
TTLA
S
AA
NI
AV
A
L
LND
QPLPAVETEISCDDL
T
MLQ
NA
CQ
RL
PAHRQA
IRG
V
F
A
GGT
F
C
Y
EA
Q-
L
I
CQQK
G
FS
A
A
SN
TPV
A
GNRA
L
AN
I
WQ
S
ED
HT
L
I
D
M
GDDDFT
R
GKPHPMIDPTLRN
Q
RL
L
N
E
LN
D
S
H
T
AV
V
L
F
D
L
VLG
Y
GA
ST
T
PA
S
E
L
L
-
-
-D
Q
L
S
H
-
I
DM
N
N
A
PL
-L
IA
H
V
C
GTE
A
DPQ
I
RSQQI
SA
L
Q
N
AGVI
I
ASS
NAQ
A
A
L
W
A
fig|685038.3.peg.3894
Escherichia coli O83:H1 str. NRG 857C (1-504/519)
M
K
VK
YKVF
S
N
L
YQDSVSLM
Q
IS
A
Q
I
SKL
P
G
I
Q
QASV
V
MGTP
N
N
L
EQ
L
RDA
GL
GNE--I
NA
S
PNDL
V
IA
V
M
GE
EDIC
NEAL
VL
-
A
QQ
R
LT
S
K
P
D
DETD
SG
IK
T
P
E
KV
S
----
LE
M
A
L
E
AE
PEANLALISV
P
G
D
YAA
A
EA
M
K
AL
NLG
M
NVMMFSDNVS
I
GQ
E
KS
I
KTLARE
RQRI
VMGPDCGTAI
V
NG
I
PL
G
FANVV
K
RG
A
IGVIGASGTG
L
QE
V
TC
RI
DQL
G
A
GISQA
L
GTGG
H
DLSEEIGGISML
F
AL
D
A
L
AQ
D
D
E
T
R
VI
V
LISKPP
S
P
I
VAR
T
ILERA
E
ACGKPVV
V
N
FLG
AN
P
HDLARP
N
I
T
A
A
TTLA
S
AA
NI
AV
A
L
LND
QPLPAVETEISCDDL
T
MLQ
NA
CQ
RL
PAHRQA
IRG
V
F
A
GGT
F
C
Y
EA
Q-
L
I
CQQK
G
FS
A
A
SN
TPV
A
GNRA
L
AN
I
WQ
S
ED
HT
L
I
D
M
GDDDFT
R
GKPHPMIDPTLRN
Q
RL
L
N
E
LN
D
S
H
T
AV
V
L
F
D
L
VLG
Y
GA
ST
T
PA
S
E
L
L
-
-
-D
Q
L
S
H
-
I
DM
N
N
A
PL
-L
IA
H
V
C
GTE
A
DPQ
I
RSQQI
SA
L
Q
N
AGVI
I
ASS
NAQ
A
A
L
W
A
fig|656440.3.peg.4164
Escherichia coli TA206 (1-504/519)
M
K
VK
YKVF
S
N
L
YQDSVSLM
Q
IS
A
Q
I
SKL
P
G
I
Q
QASV
V
MGTP
N
N
L
EQ
L
RDA
GL
GNE--I
NA
S
PNDL
V
IA
V
M
GE
EDIC
NEAL
VL
-
A
QQ
R
LT
S
K
P
D
DETD
SG
IK
T
P
E
KV
S
----
LE
M
A
L
E
AE
PEANLALISV
P
G
D
YAA
A
EA
M
K
AL
NLG
M
NVMMFSDNVS
I
GQ
E
KS
I
KTLARE
RQRI
VMGPDCGTAI
V
NG
I
PL
G
FANVV
K
RG
A
IGVIGASGTG
L
QE
V
TC
RI
DQL
G
A
GISQA
L
GTGG
H
DLSEEIGGISML
F
AL
D
A
L
AQ
D
D
E
T
R
VI
V
LISKPP
S
P
I
VAR
T
ILERA
E
ACGKPVV
V
N
FLG
AN
P
HDLARP
N
I
T
A
A
TTLA
S
AA
NI
AV
A
L
LND
QPLPAVETEISCDDL
T
MLQ
NA
CQ
RL
PAHRQA
IRG
V
F
A
GGT
F
C
Y
EA
Q-
L
I
CQQK
G
FS
A
A
SN
TPV
A
GNRA
L
AN
I
WQ
S
ED
HT
L
I
D
M
GDDDFT
R
GKPHPMIDPTLRN
Q
RL
L
N
E
LN
D
S
H
T
AV
V
L
F
D
L
VLG
Y
GA
ST
T
PA
S
E
L
L
-
-
-D
Q
L
S
H
-
I
DM
N
N
A
PL
-L
IA
H
V
C
GTE
A
DPQ
I
RSQQI
SA
L
Q
N
AGVI
I
ASS
NAQ
A
A
L
W
A
fig|562.376.peg.804
Escherichia coli WV_060327 (1-504/519)
M
K
VK
YKVF
S
N
L
YQDSVSLM
Q
IS
A
Q
I
SKL
P
G
I
Q
QASV
V
MGTP
N
N
L
EQ
L
RDA
GL
GNE--I
NA
S
PNDL
V
IA
V
M
GE
EDIC
NEAL
VL
-
A
QQ
R
LT
S
K
P
D
DETD
SG
IK
T
P
E
KV
S
----
LE
M
A
L
E
AE
PEANLALISV
P
G
D
YAA
A
EA
M
K
AL
NLG
M
NVMMFSDNVS
I
GQ
E
KS
I
KTLARE
RQRI
VMGPDCGTAI
V
NG
I
PL
G
FANVV
K
RG
A
IGVIGASGTG
L
QE
V
TC
RI
DQL
G
A
GISQA
L
GTGG
H
DLSEEIGGISML
F
AL
D
A
L
AQ
D
D
E
T
R
VI
V
LISKPP
S
P
I
VAR
T
ILERA
E
ACGKPVV
V
N
FLG
AN
P
HDLARP
N
I
T
A
A
TTLA
S
AA
NI
AV
A
L
LND
QPLPAVETEISCDDL
T
MLQ
NA
CQ
RL
PAHRQA
IRG
V
F
A
GGT
F
C
Y
EA
Q-
L
I
CQQK
G
FS
A
A
SN
TPV
A
GNRA
L
AN
I
WQ
S
ED
HT
L
I
D
M
GDDDFT
R
GKPHPMIDPTLRN
Q
RL
L
N
E
LN
D
S
H
T
AV
V
L
F
D
L
VLG
Y
GA
ST
T
PA
S
E
L
L
-
-
-D
Q
L
S
H
-
I
DM
N
N
A
PL
-L
IA
H
V
C
GTE
A
DPQ
I
RSQQI
SA
L
Q
N
AGVI
I
ASS
NAQ
A
A
L
W
A
fig|405955.13.peg.4291
Escherichia coli APEC O1 (1-504/519)
M
K
VK
YKVF
S
N
L
YQDSVSLM
Q
IS
A
Q
I
SKL
P
G
I
Q
QASV
V
MGTP
N
N
L
EQ
L
RDA
GL
GNE--I
NA
S
PNDL
V
IA
V
M
GE
EDIC
NEAL
VL
-
A
QQ
R
LT
S
K
P
D
DETD
SG
IK
T
P
E
KV
S
----
LE
M
A
L
E
AE
PEANLALISV
P
G
D
YAA
A
EA
I
K
AL
NLG
M
NVMMFSDNVS
I
GQ
E
KS
I
KTLARE
RQRI
VMGPDCGTAI
V
NG
I
PL
G
FANVV
K
RG
A
IGVIGASGTG
L
QE
V
TC
RI
DQL
G
A
GISQA
L
GTGG
H
DLSEEIGGISML
F
AL
D
A
L
AQ
D
D
E
T
R
VI
V
LISKPP
S
P
I
VA
Q
T
ILERA
E
ACGKPVV
V
N
FLG
AN
P
HDLARP
N
I
T
A
A
TTLA
S
AA
NI
AV
A
L
LN
A
QPLPAVETEISCADL
T
MLQ
NA
CQ
RL
PAHRQA
IRG
V
F
A
GGT
F
C
Y
EA
Q-
L
I
CQQK
G
FS
A
A
SN
TPV
A
GNRA
L
AN
I
WQ
S
ED
HT
L
I
D
M
GDDDFT
R
GKPHPMIDPTLRN
Q
RL
L
N
E
LN
D
S
H
T
AV
V
L
F
D
L
VLG
Y
GA
ST
A
PA
S
E
L
L
-
-
-D
Q
L
S
H
-
I
DM
N
N
A
PL
-L
IA
H
V
C
GTE
A
DPQ
I
RSQQI
RA
L
Q
N
AGVI
I
ASS
NAQ
A
A
L
W
A
fig|405955.9.peg.3603
Escherichia coli APEC O1 (1-504/519)
M
K
VK
YKVF
S
N
L
YQDSVSLM
Q
IS
A
Q
I
SKL
P
G
I
Q
QASV
V
MGTP
N
N
L
EQ
L
RDA
GL
GNE--I
NA
S
PNDL
V
IA
V
M
GE
EDIC
NEAL
VL
-
A
QQ
R
LT
S
K
P
D
DETD
SG
IK
T
P
E
KV
S
----
LE
M
A
L
E
AE
PEANLALISV
P
G
D
YAA
A
EA
I
K
AL
NLG
M
NVMMFSDNVS
I
GQ
E
KS
I
KTLARE
RQRI
VMGPDCGTAI
V
NG
I
PL
G
FANVV
K
RG
A
IGVIGASGTG
L
QE
V
TC
RI
DQL
G
A
GISQA
L
GTGG
H
DLSEEIGGISML
F
AL
D
A
L
AQ
D
D
E
T
R
VI
V
LISKPP
S
P
I
VA
Q
T
ILERA
E
ACGKPVV
V
N
FLG
AN
P
HDLARP
N
I
T
A
A
TTLA
S
AA
NI
AV
A
L
LN
A
QPLPAVETEISCADL
T
MLQ
NA
CQ
RL
PAHRQA
IRG
V
F
A
GGT
F
C
Y
EA
Q-
L
I
CQQK
G
FS
A
A
SN
TPV
A
GNRA
L
AN
I
WQ
S
ED
HT
L
I
D
M
GDDDFT
R
GKPHPMIDPTLRN
Q
RL
L
N
E
LN
D
S
H
T
AV
V
L
F
D
L
VLG
Y
GA
ST
A
PA
S
E
L
L
-
-
-D
Q
L
S
H
-
I
DM
N
N
A
PL
-L
IA
H
V
C
GTE
A
DPQ
I
RSQQI
RA
L
Q
N
AGVI
I
ASS
NAQ
A
A
L
W
A
fig|714962.3.peg.4326
Escherichia coli IHE3034 (1-504/519)
M
K
VK
YKVF
S
N
L
YQDSVSLM
Q
IS
A
Q
I
SKL
P
G
I
Q
QASV
V
MGTP
N
N
L
EQ
L
RDA
GL
GNE--I
NA
S
PNDL
V
IA
V
M
GE
EDIC
NEAL
VL
-
A
QQ
R
LT
S
K
P
D
DETD
SG
IK
T
P
E
KV
S
----
LE
M
A
L
E
AE
PEANLALISV
P
G
D
YAA
A
EA
I
K
AL
NLG
M
NVMMFSDNVS
I
GQ
E
KS
I
KTLARE
RQRI
VMGPDCGTAI
V
NG
I
PL
G
FANVV
K
RG
A
IGVIGASGTG
L
QE
V
TC
RI
DQL
G
A
GISQA
L
GTGG
H
DLSEEIGGISML
F
AL
D
A
L
AQ
D
D
E
T
R
VI
V
LISKPP
S
P
I
VA
Q
T
ILERA
E
ACGKPVV
V
N
FLG
AN
P
HDLARP
N
I
T
A
A
TTLA
S
AA
NI
AV
A
L
LN
A
QPLPAVETEISCADL
T
MLQ
NA
CQ
RL
PAHRQA
IRG
V
F
A
GGT
F
C
Y
EA
Q-
L
I
CQQK
G
FS
A
A
SN
TPV
A
GNRA
L
AN
I
WQ
S
ED
HT
L
I
D
M
GDDDFT
R
GKPHPMIDPTLRN
Q
RL
L
N
E
LN
D
S
H
T
AV
V
L
F
D
L
VLG
Y
GA
ST
A
PA
S
E
L
L
-
-
-D
Q
L
S
H
-
I
DM
N
N
A
PL
-L
IA
H
V
C
GTE
A
DPQ
I
RSQQI
RA
L
Q
N
AGVI
I
ASS
NAQ
A
A
L
W
A
fig|585035.6.peg.4189
Escherichia coli S88 (1-504/519)
M
K
VK
YKVF
S
N
L
YQDSVSLM
Q
IS
A
Q
I
SKL
P
G
I
Q
QASV
V
MGTP
N
N
L
EQ
L
RDA
GL
GNE--I
NA
S
PNDL
V
IA
V
M
GE
EDIC
NEAL
VL
-
A
QQ
R
LT
S
K
P
D
DETD
SG
IK
T
P
E
KV
S
----
LE
M
A
L
E
AE
PEANLALISV
P
G
D
YAA
A
EA
I
K
AL
NLG
M
NVMMFSDNVS
I
GQ
E
KS
I
KTLARE
RQRI
VMGPDCGTAI
V
NG
I
PL
G
FANVV
K
RG
A
IGVIGASGTG
L
QE
V
TC
RI
DQL
G
A
GISQA
L
GTGG
H
DLSEEIGGISML
F
AL
D
A
L
AQ
D
D
E
T
R
VI
V
LISKPP
S
P
I
VA
Q
T
ILERA
E
ACGKPVV
V
N
FLG
AN
P
HDLARP
N
I
T
A
A
TTLA
S
AA
NI
AV
A
L
LN
A
QPLPAVETEISCADL
T
MLQ
NA
CQ
RL
PAHRQA
IRG
V
F
A
GGT
F
C
Y
EA
Q-
L
I
CQQK
G
FS
A
A
SN
TPV
A
GNRA
L
AN
I
WQ
S
ED
HT
L
I
D
M
GDDDFT
R
GKPHPMIDPTLRN
Q
RL
L
N
E
LN
D
S
H
T
AV
V
L
F
D
L
VLG
Y
GA
ST
A
PA
S
E
L
L
-
-
-D
Q
L
S
H
-
I
DM
N
N
A
PL
-L
IA
H
V
C
GTE
A
DPQ
I
RSQQI
RA
L
Q
N
AGVI
I
ASS
NAQ
A
A
L
W
A
fig|869729.3.peg.4152
Escherichia coli UM146 (1-504/519)
M
K
VK
YKVF
S
N
L
YQDSVSLM
Q
IS
A
Q
I
SKL
P
G
I
Q
QASV
V
MGTP
N
N
L
EQ
L
RDA
GL
GNE--I
NA
S
PNDL
V
IA
V
M
GE
EDIC
NEAL
VL
-
A
QQ
R
LT
S
K
P
D
DETD
SG
IK
T
P
E
KV
S
----
LE
M
A
L
E
AE
PEANLALISV
P
G
D
YAA
A
EA
I
K
AL
NLG
M
NVMMFSDNVS
I
GQ
E
KS
I
KTLARE
RQRI
VMGPDCGTAI
V
NG
I
PL
G
FANVV
K
RG
A
IGVIGASGTG
L
QE
V
TC
RI
DQL
G
A
GISQA
L
GTGG
H
DLSEEIGGISML
F
AL
D
A
L
AQ
D
D
E
T
R
VI
V
LISKPP
S
P
I
VA
Q
T
ILERA
E
ACGKPVV
V
N
FLG
AN
P
HDLARP
N
I
T
A
A
TTLA
S
AA
NI
AV
A
L
LN
A
QPLPAVETEISCADL
T
MLQ
NA
CQ
RL
PAHRQA
IRG
V
F
A
GGT
F
C
Y
EA
Q-
L
I
CQQK
G
FS
A
A
SN
TPV
A
GNRA
L
AN
I
WQ
S
ED
HT
L
I
D
M
GDDDFT
R
GKPHPMIDPTLRN
Q
RL
L
N
E
LN
D
S
H
T
AV
V
L
F
D
L
VLG
Y
GA
ST
A
PA
S
E
L
L
-
-
-D
Q
L
S
H
-
I
DM
N
N
A
PL
-L
IA
H
V
C
GTE
A
DPQ
I
RSQQI
RA
L
Q
N
AGVI
I
ASS
NAQ
A
A
L
W
A
fig|364106.7.peg.4295
Escherichia coli UTI89 (1-504/519)
M
K
VK
YKVF
S
N
L
YQDSVSLM
Q
IS
A
Q
I
SKL
P
G
I
Q
QASV
V
MGTP
N
N
L
EQ
L
RDA
GL
GNE--I
NA
S
PNDL
V
IA
V
M
GE
EDIC
NEAL
VL
-
A
QQ
R
LT
S
K
P
D
DETD
SG
IK
T
P
E
KV
S
----
LE
M
A
L
E
AE
PEANLALISV
P
G
D
YAA
A
EA
I
K
AL
NLG
M
NVMMFSDNVS
I
GQ
E
KS
I
KTLARE
RQRI
VMGPDCGTAI
V
NG
I
PL
G
FANVV
K
RG
A
IGVIGASGTG
L
QE
V
TC
RI
DQL
G
A
GISQA
L
GTGG
H
DLSEEIGGISML
F
AL
D
A
L
AQ
D
D
E
T
R
VI
V
LISKPP
S
P
I
VA
Q
T
ILERA
E
ACGKPVV
V
N
FLG
AN
P
HDLARP
N
I
T
A
A
TTLA
S
AA
NI
AV
A
L
LN
A
QPLPAVETEISCADL
T
MLQ
NA
CQ
RL
PAHRQA
IRG
V
F
A
GGT
F
C
Y
EA
Q-
L
I
CQQK
G
FS
A
A
SN
TPV
A
GNRA
L
AN
I
WQ
S
ED
HT
L
I
D
M
GDDDFT
R
GKPHPMIDPTLRN
Q
RL
L
N
E
LN
D
S
H
T
AV
V
L
F
D
L
VLG
Y
GA
ST
A
PA
S
E
L
L
-
-
-D
Q
L
S
H
-
I
DM
N
N
A
PL
-L
IA
H
V
C
GTE
A
DPQ
I
RSQQI
RA
L
Q
N
AGVI
I
ASS
NAQ
A
A
L
W
A
fig|364106.8.peg.4297
Escherichia coli UTI89 (1-504/519)
M
K
VK
YKVF
S
N
L
YQDSVSLM
Q
IS
A
Q
I
SKL
P
G
I
Q
QASV
V
MGTP
N
N
L
EQ
L
RDA
GL
GNE--I
NA
S
PNDL
V
IA
V
M
GE
EDIC
NEAL
VL
-
A
QQ
R
LT
S
K
P
D
DETD
SG
IK
T
P
E
KV
S
----
LE
M
A
L
E
AE
PEANLALISV
P
G
D
YAA
A
EA
I
K
AL
NLG
M
NVMMFSDNVS
I
GQ
E
KS
I
KTLARE
RQRI
VMGPDCGTAI
V
NG
I
PL
G
FANVV
K
RG
A
IGVIGASGTG
L
QE
V
TC
RI
DQL
G
A
GISQA
L
GTGG
H
DLSEEIGGISML
F
AL
D
A
L
AQ
D
D
E
T
R
VI
V
LISKPP
S
P
I
VA
Q
T
ILERA
E
ACGKPVV
V
N
FLG
AN
P
HDLARP
N
I
T
A
A
TTLA
S
AA
NI
AV
A
L
LN
A
QPLPAVETEISCADL
T
MLQ
NA
CQ
RL
PAHRQA
IRG
V
F
A
GGT
F
C
Y
EA
Q-
L
I
CQQK
G
FS
A
A
SN
TPV
A
GNRA
L
AN
I
WQ
S
ED
HT
L
I
D
M
GDDDFT
R
GKPHPMIDPTLRN
Q
RL
L
N
E
LN
D
S
H
T
AV
V
L
F
D
L
VLG
Y
GA
ST
A
PA
S
E
L
L
-
-
-D
Q
L
S
H
-
I
DM
N
N
A
PL
-L
IA
H
V
C
GTE
A
DPQ
I
RSQQI
RA
L
Q
N
AGVI
I
ASS
NAQ
A
A
L
W
A
fig|358709.5.peg.3317
Escherichia coli 101-1 (1-504/519)
M
K
VK
YKVF
S
N
L
YQDSVSLM
Q
IS
A
Q
I
SKL
P
G
I
Q
QASV
V
MGTP
N
N
L
EQ
L
RDA
GL
GNE--I
NA
S
PNDL
V
IA
V
M
GE
EDIC
NEAL
VL
-
A
QQ
R
LT
S
K
P
D
DETD
SG
IK
S
P
E
KV
S
----
LE
M
A
L
E
AE
PEANLALISV
P
G
D
YAA
A
EA
I
K
AL
NLG
M
NVMMFSDNVS
I
V
Q
E
KS
I
KTLARE
RQRI
VMGPDCGTAI
V
NG
I
PL
G
FANVV
K
RG
A
IGVIGASGTG
L
QE
V
TC
RI
DQL
G
A
GISQA
L
GTGG
H
DLSEEIGGISML
F
AL
D
A
L
AQ
D
D
E
T
R
VI
V
LISKPP
S
P
I
VAR
T
ILERA
E
ACGKPVV
V
N
FLG
AN
P
HDLARP
N
I
T
A
A
TTLA
S
AA
NI
AV
A
L
LND
QPLPTIETEISCDDL
T
MLQ
NA
CQ
RL
PAHRQA
IRG
V
F
A
GGT
F
C
Y
EA
Q-
L
I
CQQK
G
FS
A
A
SN
TPV
A
GNRA
L
AN
I
WQ
S
ED
HT
L
I
D
M
GDDDFT
R
GKPHPMIDPTLRN
Q
RL
L
N
E
LN
D
S
H
T
AV
V
L
F
D
L
VLG
Y
GA
ST
T
PA
S
E
L
L
-
-
-D
Q
L
S
H
-
I
DM
N
N
A
PL
-L
IA
H
V
C
GTE
A
DPQ
I
RSQQI
SA
L
Q
N
AG
I
I
I
ASS
NAQ
A
A
L
W
A
fig|413997.3.peg.3894
Escherichia coli B str. REL606 (1-504/519)
M
K
VK
YKVF
S
N
L
YQDSVSLM
Q
IS
A
Q
I
SKL
P
G
I
Q
QASV
V
MGTP
N
N
L
EQ
L
RDA
GL
GNE--I
NA
S
PNDL
V
IA
V
M
GE
EDIC
NEAL
VL
-
A
QQ
R
LT
S
K
P
D
DETD
SG
IK
S
P
E
KV
S
----
LE
M
A
L
E
AE
PEANLALISV
P
G
D
YAA
A
EA
I
K
AL
NLG
M
NVMMFSDNVS
I
V
Q
E
KS
I
KTLARE
RQRI
VMGPDCGTAI
V
NG
I
PL
G
FANVV
K
RG
A
IGVIGASGTG
L
QE
V
TC
RI
DQL
G
A
GISQA
L
GTGG
H
DLSEEIGGISML
F
AL
D
A
L
AQ
D
D
E
T
R
VI
V
LISKPP
S
P
I
VAR
T
ILERA
E
ACGKPVV
V
N
FLG
AN
P
HDLARP
N
I
T
A
A
TTLA
S
AA
NI
AV
A
L
LND
QPLPTIETEISCDDL
T
MLQ
NA
CQ
RL
PAHRQA
IRG
V
F
A
GGT
F
C
Y
EA
Q-
L
I
CQQK
G
FS
A
A
SN
TPV
A
GNRA
L
AN
I
WQ
S
ED
HT
L
I
D
M
GDDDFT
R
GKPHPMIDPTLRN
Q
RL
L
N
E
LN
D
S
H
T
AV
V
L
F
D
L
VLG
Y
GA
ST
T
PA
S
E
L
L
-
-
-D
Q
L
S
H
-
I
DM
N
N
A
PL
-L
IA
H
V
C
GTE
A
DPQ
I
RSQQI
SA
L
Q
N
AG
I
I
I
ASS
NAQ
A
A
L
W
A
fig|511693.5.peg.3912
Escherichia coli BL21 (1-504/519)
M
K
VK
YKVF
S
N
L
YQDSVSLM
Q
IS
A
Q
I
SKL
P
G
I
Q
QASV
V
MGTP
N
N
L
EQ
L
RDA
GL
GNE--I
NA
S
PNDL
V
IA
V
M
GE
EDIC
NEAL
VL
-
A
QQ
R
LT
S
K
P
D
DETD
SG
IK
S
P
E
KV
S
----
LE
M
A
L
E
AE
PEANLALISV
P
G
D
YAA
A
EA
I
K
AL
NLG
M
NVMMFSDNVS
I
V
Q
E
KS
I
KTLARE
RQRI
VMGPDCGTAI
V
NG
I
PL
G
FANVV
K
RG
A
IGVIGASGTG
L
QE
V
TC
RI
DQL
G
A
GISQA
L
GTGG
H
DLSEEIGGISML
F
AL
D
A
L
AQ
D
D
E
T
R
VI
V
LISKPP
S
P
I
VAR
T
ILERA
E
ACGKPVV
V
N
FLG
AN
P
HDLARP
N
I
T
A
A
TTLA
S
AA
NI
AV
A
L
LND
QPLPTIETEISCDDL
T
MLQ
NA
CQ
RL
PAHRQA
IRG
V
F
A
GGT
F
C
Y
EA
Q-
L
I
CQQK
G
FS
A
A
SN
TPV
A
GNRA
L
AN
I
WQ
S
ED
HT
L
I
D
M
GDDDFT
R
GKPHPMIDPTLRN
Q
RL
L
N
E
LN
D
S
H
T
AV
V
L
F
D
L
VLG
Y
GA
ST
T
PA
S
E
L
L
-
-
-D
Q
L
S
H
-
I
DM
N
N
A
PL
-L
IA
H
V
C
GTE
A
DPQ
I
RSQQI
SA
L
Q
N
AG
I
I
I
ASS
NAQ
A
A
L
W
A
fig|469008.4.peg.4375
Escherichia coli BL21(DE3) (1-504/519)
M
K
VK
YKVF
S
N
L
YQDSVSLM
Q
IS
A
Q
I
SKL
P
G
I
Q
QASV
V
MGTP
N
N
L
EQ
L
RDA
GL
GNE--I
NA
S
PNDL
V
IA
V
M
GE
EDIC
NEAL
VL
-
A
QQ
R
LT
S
K
P
D
DETD
SG
IK
S
P
E
KV
S
----
LE
M
A
L
E
AE
PEANLALISV
P
G
D
YAA
A
EA
I
K
AL
NLG
M
NVMMFSDNVS
I
V
Q
E
KS
I
KTLARE
RQRI
VMGPDCGTAI
V
NG
I
PL
G
FANVV
K
RG
A
IGVIGASGTG
L
QE
V
TC
RI
DQL
G
A
GISQA
L
GTGG
H
DLSEEIGGISML
F
AL
D
A
L
AQ
D
D
E
T
R
VI
V
LISKPP
S
P
I
VAR
T
ILERA
E
ACGKPVV
V
N
FLG
AN
P
HDLARP
N
I
T
A
A
TTLA
S
AA
NI
AV
A
L
LND
QPLPTIETEISCDDL
T
MLQ
NA
CQ
RL
PAHRQA
IRG
V
F
A
GGT
F
C
Y
EA
Q-
L
I
CQQK
G
FS
A
A
SN
TPV
A
GNRA
L
AN
I
WQ
S
ED
HT
L
I
D
M
GDDDFT
R
GKPHPMIDPTLRN
Q
RL
L
N
E
LN
D
S
H
T
AV
V
L
F
D
L
VLG
Y
GA
ST
T
PA
S
E
L
L
-
-
-D
Q
L
S
H
-
I
DM
N
N
A
PL
-L
IA
H
V
C
GTE
A
DPQ
I
RSQQI
SA
L
Q
N
AG
I
I
I
ASS
NAQ
A
A
L
W
A
fig|749547.3.peg.2224
Escherichia coli MS 187-1 (1-504/519)
M
K
VK
YKVF
S
N
L
YQDSVSLM
Q
IS
A
Q
I
SKL
P
G
I
Q
QASV
V
MGTP
N
N
L
EQ
L
RDA
GL
GNE--I
NA
S
PNDL
V
IA
V
M
GE
EDIC
NEAL
VL
-
A
QQ
R
LT
S
K
P
D
DETD
SG
IK
S
P
E
KV
S
----
LE
M
A
L
E
AE
PEANLALISV
P
G
D
YAA
A
EA
I
K
AL
NLG
M
NVMMFSDNVS
I
V
Q
E
KS
I
KTLARE
RQRI
VMGPDCGTAI
V
NG
I
PL
G
FANVV
K
RG
A
IGVIGASGTG
L
QE
V
TC
RI
DQL
G
A
GISQA
L
GTGG
H
DLSEEIGGISML
F
AL
D
A
L
AQ
D
D
E
T
R
VI
V
LISKPP
S
P
I
VAR
T
ILERA
E
ACGKPVV
V
N
FLG
AN
P
HDLARP
N
I
T
A
A
TTLA
S
AA
NI
AV
A
L
LND
QPLPTIETEISCDDL
T
MLQ
NA
CQ
RL
PAHRQA
IRG
V
F
A
GGT
F
C
Y
EA
Q-
L
I
CQQK
G
FS
A
A
SN
TPV
A
GNRA
L
AN
I
WQ
S
ED
HT
L
I
D
M
GDDDFT
R
GKPHPMIDPTLRN
Q
RL
L
N
E
LN
D
S
H
T
AV
V
L
F
D
L
VLG
Y
GA
ST
T
PA
S
E
L
L
-
-
-D
Q
L
S
H
-
I
DM
N
N
A
PL
-L
IA
H
V
C
GTE
A
DPQ
I
RSQQI
SA
L
Q
N
AG
I
I
I
ASS
NAQ
A
A
L
W
A
fig|362663.8.peg.4063
Escherichia coli 536 (1-504/519)
M
K
VK
YKVF
S
N
L
YQDSVSLM
Q
IS
A
Q
I
SKL
P
G
I
Q
QASV
V
MGTP
N
N
L
EQ
L
RDA
GL
GNE--I
NA
S
PNDL
V
IA
V
M
GE
EDIC
NEAL
VL
-
A
QQ
R
LT
S
K
P
D
DETD
SG
IK
S
P
E
KV
S
----
LE
M
A
L
E
AE
PEANLALISV
P
G
D
YAA
A
EA
M
K
AL
NLG
M
NVMMFSDNVS
I
GQ
E
KS
I
KTLARE
RQRI
VMGPDCGTAI
V
NG
I
PL
G
FANVV
K
RG
A
IGVIGASGTG
L
QE
V
TC
RI
DQL
G
A
GISQA
L
GTGG
H
DLSEEIGGISML
F
AL
D
A
L
AQ
D
D
E
T
R
VI
V
LISKPP
S
P
I
VA
Q
T
ILERA
E
ACGKPVV
V
N
FLG
AN
P
HDLARP
N
I
T
A
A
TTLA
S
AA
NI
AV
A
L
LND
QPIPAVETEISCDDL
T
MLQ
NA
CQ
RL
PAHRQA
IRG
V
F
A
GGT
F
C
Y
EA
Q-
L
I
CQQK
G
FS
A
A
SN
TPV
A
GNRA
L
AN
I
WQ
S
ED
HT
L
I
D
M
GDDDFT
R
GKPHPMIDPTLRN
Q
RL
L
N
E
LN
D
S
H
T
AV
V
L
F
D
L
VLG
Y
GA
ST
T
PA
S
E
L
L
-
-
-D
Q
L
S
H
-
I
DM
N
N
A
PL
-L
IA
H
V
C
GTE
A
DPQ
I
RSQQI
RA
L
Q
N
AGVI
I
ASS
NAQ
A
A
L
W
A
fig|362663.9.peg.4079
Escherichia coli 536 (1-504/519)
M
K
VK
YKVF
S
N
L
YQDSVSLM
Q
IS
A
Q
I
SKL
P
G
I
Q
QASV
V
MGTP
N
N
L
EQ
L
RDA
GL
GNE--I
NA
S
PNDL
V
IA
V
M
GE
EDIC
NEAL
VL
-
A
QQ
R
LT
S
K
P
D
DETD
SG
IK
S
P
E
KV
S
----
LE
M
A
L
E
AE
PEANLALISV
P
G
D
YAA
A
EA
M
K
AL
NLG
M
NVMMFSDNVS
I
GQ
E
KS
I
KTLARE
RQRI
VMGPDCGTAI
V
NG
I
PL
G
FANVV
K
RG
A
IGVIGASGTG
L
QE
V
TC
RI
DQL
G
A
GISQA
L
GTGG
H
DLSEEIGGISML
F
AL
D
A
L
AQ
D
D
E
T
R
VI
V
LISKPP
S
P
I
VA
Q
T
ILERA
E
ACGKPVV
V
N
FLG
AN
P
HDLARP
N
I
T
A
A
TTLA
S
AA
NI
AV
A
L
LND
QPIPAVETEISCDDL
T
MLQ
NA
CQ
RL
PAHRQA
IRG
V
F
A
GGT
F
C
Y
EA
Q-
L
I
CQQK
G
FS
A
A
SN
TPV
A
GNRA
L
AN
I
WQ
S
ED
HT
L
I
D
M
GDDDFT
R
GKPHPMIDPTLRN
Q
RL
L
N
E
LN
D
S
H
T
AV
V
L
F
D
L
VLG
Y
GA
ST
T
PA
S
E
L
L
-
-
-D
Q
L
S
H
-
I
DM
N
N
A
PL
-L
IA
H
V
C
GTE
A
DPQ
I
RSQQI
RA
L
Q
N
AGVI
I
ASS
NAQ
A
A
L
W
A
fig|340197.3.peg.4062
Escherichia coli F11 (1-504/519)
M
K
VK
YKVF
S
N
L
YQDSVSLM
Q
IS
A
Q
I
SKL
P
G
I
Q
QASV
V
MGTP
N
N
L
EQ
L
RDA
GL
GNE--I
NA
S
PNDL
V
IA
V
M
GE
EDIC
NEAL
VL
-
A
QQ
R
LT
S
K
P
D
DETD
SG
IK
S
P
E
KV
S
----
LE
M
A
L
E
AE
PEANLALISV
P
G
D
YAA
A
EA
M
K
AL
NLG
M
NVMMFSDNVS
I
GQ
E
KS
I
KTLARE
RQRI
VMGPDCGTAI
V
NG
I
PL
G
FANVV
K
RG
A
IGVIGASGTG
L
QE
V
TC
RI
DQL
G
A
GISQA
L
GTGG
H
DLSEEIGGISML
F
AL
D
A
L
AQ
D
D
E
T
R
VI
V
LISKPP
S
P
I
VA
Q
T
ILERA
E
ACGKPVV
V
N
FLG
AN
P
HDLARP
N
I
T
A
A
TTLA
S
AA
NI
AV
A
L
LND
QPIPAVETEISCDDL
T
MLQ
NA
CQ
RL
PAHRQA
IRG
V
F
A
GGT
F
C
Y
EA
Q-
L
I
CQQK
G
FS
A
A
SN
TPV
A
GNRA
L
AN
I
WQ
S
ED
HT
L
I
D
M
GDDDFT
R
GKPHPMIDPTLRN
Q
RL
L
N
E
LN
D
S
H
T
AV
V
L
F
D
L
VLG
Y
GA
ST
T
PA
S
E
L
L
-
-
-D
Q
L
S
H
-
I
DM
N
N
A
PL
-L
IA
H
V
C
GTE
A
DPQ
I
RSQQI
RA
L
Q
N
AGVI
I
ASS
NAQ
A
A
L
W
A
fig|340197.5.peg.4237
Escherichia coli F11 (1-504/519)
M
K
VK
YKVF
S
N
L
YQDSVSLM
Q
IS
A
Q
I
SKL
P
G
I
Q
QASV
V
MGTP
N
N
L
EQ
L
RDA
GL
GNE--I
NA
S
PNDL
V
IA
V
M
GE
EDIC
NEAL
VL
-
A
QQ
R
LT
S
K
P
D
DETD
SG
IK
S
P
E
KV
S
----
LE
M
A
L
E
AE
PEANLALISV
P
G
D
YAA
A
EA
M
K
AL
NLG
M
NVMMFSDNVS
I
GQ
E
KS
I
KTLARE
RQRI
VMGPDCGTAI
V
NG
I
PL
G
FANVV
K
RG
A
IGVIGASGTG
L
QE
V
TC
RI
DQL
G
A
GISQA
L
GTGG
H
DLSEEIGGISML
F
AL
D
A
L
AQ
D
D
E
T
R
VI
V
LISKPP
S
P
I
VA
Q
T
ILERA
E
ACGKPVV
V
N
FLG
AN
P
HDLARP
N
I
T
A
A
TTLA
S
AA
NI
AV
A
L
LND
QPIPAVETEISCDDL
T
MLQ
NA
CQ
RL
PAHRQA
IRG
V
F
A
GGT
F
C
Y
EA
Q-
L
I
CQQK
G
FS
A
A
SN
TPV
A
GNRA
L
AN
I
WQ
S
ED
HT
L
I
D
M
GDDDFT
R
GKPHPMIDPTLRN
Q
RL
L
N
E
LN
D
S
H
T
AV
V
L
F
D
L
VLG
Y
GA
ST
T
PA
S
E
L
L
-
-
-D
Q
L
S
H
-
I
DM
N
N
A
PL
-L
IA
H
V
C
GTE
A
DPQ
I
RSQQI
RA
L
Q
N
AGVI
I
ASS
NAQ
A
A
L
W
A
fig|749550.3.peg.1257
Escherichia coli MS 200-1 (1-504/519)
M
K
VK
YKVF
S
N
L
YQDSVSLM
Q
IS
A
Q
I
SKL
P
G
I
Q
QASV
V
MGTP
N
N
L
EQ
L
RDA
GL
GNE--I
NA
S
PNDL
V
IA
V
M
GE
EDIC
NEAL
VL
-
A
QQ
R
LT
S
K
P
D
DETD
SG
IK
S
P
E
KV
S
----
LE
M
A
L
E
AE
PEANLALISV
P
G
D
YAA
A
EA
M
K
AL
NLG
M
NVMMFSDNVS
I
GQ
E
KS
I
KTLARE
RQRI
VMGPDCGTAI
V
NG
I
PL
G
FANVV
K
RG
A
IGVIGASGTG
L
QE
V
TC
RI
DQL
G
A
GISQA
L
GTGG
H
DLSEEIGGISML
F
AL
D
A
L
AQ
D
D
E
T
R
VI
V
LISKPP
S
P
I
VA
Q
T
ILERA
E
ACGKPVV
V
N
FLG
AN
P
HDLARP
N
I
T
A
A
TTLA
S
AA
NI
AV
A
L
LND
QPIPAVETEISCDDL
T
MLQ
NA
CQ
RL
PAHRQA
IRG
V
F
A
GGT
F
C
Y
EA
Q-
L
I
CQQK
G
FS
A
A
SN
TPV
A
GNRA
L
AN
I
WQ
S
ED
HT
L
I
D
M
GDDDFT
R
GKPHPMIDPTLRN
Q
RL
L
N
E
LN
D
S
H
T
AV
V
L
F
D
L
VLG
Y
GA
ST
T
PA
S
E
L
L
-
-
-D
Q
L
S
H
-
I
DM
N
N
A
PL
-L
IA
H
V
C
GTE
A
DPQ
I
RSQQI
RA
L
Q
N
AGVI
I
ASS
NAQ
A
A
L
W
A
fig|749531.3.peg.4328
Escherichia coli MS 69-1 (1-504/519)
M
K
VK
YKVF
S
N
L
YQDSVSLM
Q
IS
A
Q
I
SKL
P
G
I
Q
QASV
V
MGTP
N
N
L
EQ
L
RDA
GL
GNE--I
NA
S
PNDL
V
IA
V
M
GE
EDIC
NEAL
AL
-
A
QQ
R
LT
S
K
P
D
DETD
SG
IK
T
P
E
NV
S
----
LD
M
A
L
E
AE
PEANLALISV
P
G
D
YAA
A
EA
I
K
AL
NLG
M
NVMMFSDNVS
I
A
Q
E
KS
I
K
I
LARE
RQRI
VMGPDCGTAI
V
NG
I
PL
G
FANVV
K
RG
A
IGVIGASGTG
L
QE
V
TC
RI
DQL
G
A
GISQA
L
GTGG
H
DLSEEIGGISML
F
AL
D
A
L
AQ
D
D
E
T
R
VI
V
LISKPP
S
P
I
VAR
T
ILERA
E
ACGKPVV
V
N
FLG
AN
P
HDLARP
N
I
T
A
A
TTLA
S
AA
DI
AV
A
L
LN
A
QPLPAVETEISCADL
T
MLQ
NA
CQ
RL
PAHRQA
IRG
V
F
A
GGT
F
C
Y
EA
Q-
L
I
CQQK
G
FR
A
A
SN
TPV
A
SNRT
L
AN
I
WQ
S
ED
HT
L
I
D
M
GDDDFT
R
GKPHPMIDPTLRN
Q
RL
L
N
E
LN
D
S
H
T
AV
V
L
F
D
L
VLG
Y
GA
SA
T
PA
S
E
L
L
-
-
-D
Q
L
S
H
-
I
DM
N
N
A
PL
-L
IA
H
V
C
GTE
A
DPQ
I
RSQQI
SA
L
Q
N
AG
I
I
I
ASS
NAQ
A
A
L
W
A
fig|431946.3.peg.3826
Escherichia coli SE15 (1-504/519)
M
K
VK
YKVF
S
N
L
YQDSVSLM
Q
IS
A
Q
I
SKL
P
G
I
Q
QASV
V
MGTP
N
N
L
EQ
L
RDA
GL
GNE--I
NA
S
PNDL
V
IA
V
M
GE
EDIC
NEAL
IL
-
A
QQ
R
LT
S
K
P
D
DETD
SG
IK
T
P
E
KV
S
----
LE
M
A
L
E
AE
PEANLALISV
P
G
D
YAA
A
EA
I
K
AL
NLG
M
NVMMFSDNVS
I
V
Q
E
KS
I
KTLARE
RQRI
VMGPDCGTAI
V
NG
I
PL
G
FANVV
K
RG
A
IGVIGASGTG
L
QE
V
TC
RI
DQL
G
A
GISQA
L
GTGG
H
DLS
K
EIGGISML
F
AL
D
A
L
AQ
D
D
E
T
R
VI
V
LISKPP
S
P
I
VAR
T
ILERA
E
ACGKPVV
V
N
FLG
AN
P
HDLARP
N
I
T
A
A
TTLA
S
AA
DI
AV
A
L
LN
A
QPLPAVETDVPCDDL
T
MLQ
NA
CQ
RL
PAHRQA
IRG
V
F
A
GGT
F
C
Y
EA
Q-
L
I
CQQK
G
FS
A
A
SN
TPV
A
GNRA
L
AN
I
WQ
S
ED
HT
L
I
D
M
GDDDFT
R
GKPHPMIDPTLRN
Q
RL
L
N
E
LN
D
S
H
T
AV
V
L
F
D
L
VLG
Y
GA
ST
T
PA
S
E
L
L
-
-
-D
Q
L
S
H
-
I
DM
N
N
A
PL
-L
IA
H
V
C
GTE
A
DPQ
I
RSQQI
SA
L
Q
N
AGVI
I
ASS
NAQ
A
A
L
W
A
fig|749527.3.peg.4472
Escherichia coli MS 21-1 (1-504/519)
M
K
VK
YKVF
S
N
L
YQDSVSLM
Q
IS
A
Q
I
SKL
P
G
I
Q
QASV
V
MGTP
N
N
L
EQ
L
RDA
GL
GNE--I
NA
S
PNDL
V
IA
V
M
GE
EDIC
NEAL
VL
-
A
QQ
R
LT
S
K
P
D
DETD
SG
IK
S
P
E
KV
S
----
LE
M
A
L
E
AE
PEANLALISV
P
G
D
YAA
A
EA
I
K
AL
NLG
M
NVMMFSDNVS
I
V
Q
E
KS
I
KTLARE
RQRI
VMGPDCGTAI
V
NG
I
PL
G
FANVV
K
RG
A
IGVIGASGTG
L
QE
V
TC
RI
DQL
G
A
GISQA
L
GTGG
H
DLSEEIGGISML
F
AL
D
A
L
AQ
D
D
E
T
R
VI
V
LISKPP
S
P
I
VAR
T
ILERA
E
ACGKPVV
V
N
FLG
AN
P
HDLARP
N
I
T
A
A
TTLA
S
AA
NI
AV
A
L
LND
QPLPTIETEISCDDL
T
MLQ
NA
CQ
RL
PAHRQA
IRG
V
F
A
GGT
F
C
Y
EA
Q-
L
I
CQQK
G
FI
A
A
SN
TPV
A
GNRA
L
AN
I
WQ
S
ED
HT
L
I
D
M
GDDDFT
R
GKPHPMIDPTLRN
Q
RL
L
N
E
LN
D
S
H
T
AV
V
L
F
D
L
VLG
Y
GA
ST
T
PA
S
E
L
L
-
-
-D
Q
L
S
H
-
I
DM
N
N
A
PL
-L
IA
H
V
C
GTE
A
DPQ
I
RSQQI
SA
L
Q
N
AGVI
I
ASS
NAQ
A
A
L
W
A
fig|439855.10.peg.4337
Escherichia coli SMS-3-5 (1-504/519)
M
K
VK
YKVF
S
N
L
YQDSVSLM
Q
IS
A
Q
I
SKL
P
G
I
Q
QASV
V
MGTP
N
N
L
EQ
L
SDA
GL
GNE--I
NA
S
PNDL
V
IA
V
M
GE
EDIC
NEAL
VL
-
A
QQ
R
LT
S
K
P
D
DETD
SG
IK
T
P
E
KV
S
----
LE
M
A
L
E
AE
PEANLALISV
P
G
D
YAA
A
EA
I
K
AL
NLG
M
NVMMFSDNVS
I
V
Q
E
KS
I
KTLARE
RQRI
VMGPDCGTAI
V
NG
I
PL
G
FANVV
K
RG
A
IGVIGASGTG
L
QE
V
TC
RI
DQL
G
A
GISQA
L
GTGG
H
DLSEEIGGISML
F
AL
D
A
L
AQ
D
D
E
T
R
VI
V
LISKPP
S
P
I
VAR
T
ILERA
E
ACGKPVV
V
N
FLG
AN
P
HDLARP
N
I
T
A
A
TTLA
S
AA
NI
AV
A
L
LND
QPLPTIETEISCDDL
T
MLQ
NA
CQ
RL
PAHRQA
IRG
V
F
A
GGT
F
C
Y
EA
Q-
L
I
CQQK
G
FS
A
A
SN
TPV
A
GNRA
L
AN
I
WQ
S
ED
HT
L
I
D
M
GDDDFT
R
GKPHPMIDPTLRN
Q
RL
L
N
E
LN
D
S
H
T
AV
V
L
F
D
L
VLG
Y
GA
ST
T
PA
S
E
L
L
-
-
-D
Q
L
S
H
-
I
DM
N
N
A
PL
-L
IA
H
V
C
GTE
A
DPQ
I
RSQQI
SA
L
Q
N
AGVI
I
ASS
NAQ
A
A
L
W
A
fig|670897.3.peg.5074
Escherichia coli 2362-75 (1-504/519)
M
K
VK
YKVF
S
N
L
YQDSVSLM
Q
IS
A
Q
I
SKL
P
G
I
Q
QASV
V
MGTP
N
N
L
EQ
L
RDA
GL
GNE--I
NA
S
PNDL
V
IA
V
M
GE
EDIC
NEAL
VL
-
A
QQ
R
LT
S
K
P
D
DETD
SG
IK
T
P
E
KV
S
----
LE
M
A
L
E
AE
PEANLALISV
P
G
D
YAA
A
EA
M
K
AL
NLG
M
NV
I
MFSDNVS
I
GQ
E
KS
I
KTLARE
RQRI
VMGPDCGTAI
V
NG
I
PL
G
FANVV
K
RG
A
IGVIGASGTG
L
QE
V
TC
RI
DQL
G
A
GISQA
L
GTGG
H
DLSEEIGGISML
F
AL
D
A
L
AQ
D
D
E
T
R
VI
V
LISKPP
S
P
I
VA
Q
T
ILERA
E
ACGKPVV
V
N
FLG
AN
P
HDLARP
N
I
T
A
A
TTLA
S
AA
NI
AV
A
L
LND
QPIPAVETEISCDDL
T
MLQ
NA
CQ
RL
PAHRQA
IRG
V
F
A
GGT
F
C
Y
EA
Q-
L
I
CQQK
G
FS
A
A
SN
TPV
A
GNRA
L
AN
I
WQ
S
ED
HT
L
I
D
M
GDDDFT
R
GKPHPMIDPTLRN
Q
RL
L
N
E
LN
D
S
H
T
AV
V
L
F
D
L
VLG
Y
GA
ST
T
PA
S
E
L
L
-
-
-D
Q
L
S
H
-
I
DM
N
N
A
PL
-L
IA
H
V
C
GTE
A
DPQ
I
RSQQI
SA
L
Q
N
AG
I
I
I
ASS
NAQ
A
A
L
W
A
fig|216593.1.peg.4649
Escherichia coli E2348/69 (1-504/519)
M
K
VK
YKVF
S
N
L
YQDSVSLM
Q
IS
A
Q
I
SKL
P
G
I
Q
QASV
V
MGTP
N
N
L
EQ
L
RDA
GL
GNE--I
NA
S
PNDL
V
IA
V
M
GE
EDIC
NEAL
VL
-
A
QQ
R
LT
S
K
P
D
DETD
SG
IK
T
P
E
KV
S
----
LE
M
A
L
E
AE
PEANLALISV
P
G
D
YAA
A
EA
M
K
AL
NLG
M
NV
I
MFSDNVS
I
GQ
E
KS
I
KTLARE
RQRI
VMGPDCGTAI
V
NG
I
PL
G
FANVV
K
RG
A
IGVIGASGTG
L
QE
V
TC
RI
DQL
G
A
GISQA
L
GTGG
H
DLSEEIGGISML
F
AL
D
A
L
AQ
D
D
E
T
R
VI
V
LISKPP
S
P
I
VA
Q
T
ILERA
E
ACGKPVV
V
N
FLG
AN
P
HDLARP
N
I
T
A
A
TTLA
S
AA
NI
AV
A
L
LND
QPIPAVETEISCDDL
T
MLQ
NA
CQ
RL
PAHRQA
IRG
V
F
A
GGT
F
C
Y
EA
Q-
L
I
CQQK
G
FS
A
A
SN
TPV
A
GNRA
L
AN
I
WQ
S
ED
HT
L
I
D
M
GDDDFT
R
GKPHPMIDPTLRN
Q
RL
L
N
E
LN
D
S
H
T
AV
V
L
F
D
L
VLG
Y
GA
ST
T
PA
S
E
L
L
-
-
-D
Q
L
S
H
-
I
DM
N
N
A
PL
-L
IA
H
V
C
GTE
A
DPQ
I
RSQQI
SA
L
Q
N
AG
I
I
I
ASS
NAQ
A
A
L
W
A
fig|574521.7.peg.4224
Escherichia coli O127:H6 str. E2348/69 (1-504/519)
M
K
VK
YKVF
S
N
L
YQDSVSLM
Q
IS
A
Q
I
SKL
P
G
I
Q
QASV
V
MGTP
N
N
L
EQ
L
RDA
GL
GNE--I
NA
S
PNDL
V
IA
V
M
GE
EDIC
NEAL
VL
-
A
QQ
R
LT
S
K
P
D
DETD
SG
IK
T
P
E
KV
S
----
LE
M
A
L
E
AE
PEANLALISV
P
G
D
YAA
A
EA
M
K
AL
NLG
M
NV
I
MFSDNVS
I
GQ
E
KS
I
KTLARE
RQRI
VMGPDCGTAI
V
NG
I
PL
G
FANVV
K
RG
A
IGVIGASGTG
L
QE
V
TC
RI
DQL
G
A
GISQA
L
GTGG
H
DLSEEIGGISML
F
AL
D
A
L
AQ
D
D
E
T
R
VI
V
LISKPP
S
P
I
VA
Q
T
ILERA
E
ACGKPVV
V
N
FLG
AN
P
HDLARP
N
I
T
A
A
TTLA
S
AA
NI
AV
A
L
LND
QPIPAVETEISCDDL
T
MLQ
NA
CQ
RL
PAHRQA
IRG
V
F
A
GGT
F
C
Y
EA
Q-
L
I
CQQK
G
FS
A
A
SN
TPV
A
GNRA
L
AN
I
WQ
S
ED
HT
L
I
D
M
GDDDFT
R
GKPHPMIDPTLRN
Q
RL
L
N
E
LN
D
S
H
T
AV
V
L
F
D
L
VLG
Y
GA
ST
T
PA
S
E
L
L
-
-
-D
Q
L
S
H
-
I
DM
N
N
A
PL
-L
IA
H
V
C
GTE
A
DPQ
I
RSQQI
SA
L
Q
N
AG
I
I
I
ASS
NAQ
A
A
L
W
A
fig|749548.3.peg.1735
Escherichia coli MS 196-1 (6-493/555)
IK
K
G
C
F
QDSVSLM
I
IS
R
K
L
S
ES
E
N
VD
DV
SV
M
MGTP
A
NK
AL
L
DTT
G
F
WHDDFN
NA
T
PND
I
C
V
AI
R
S
E
AADA
GI
A
Q
AI
-
M
QQL
EE
A
L
K
Q
LAQG
SG
--
S
S
Q
AL
M
QVRR
WD
SA
C
Q
KL
P
D
ANLALISV
A
G
E
YAA
E
L
A
N
QAL
DRN
LNVMMFSDNV
T
LEDE
IQ
LKT
R
AREKGLLVMGPDCGT
SM
I
A
G
T
PL
A
FANV
M
P
E
GNIGVIGASGTG
I
QEL
CS
Q
I
ALA
G
E
GI
TH
AIG
L
GGRDLS
R
E
V
GGIS
A
L
T
AL
E
ML
SA
D
E
K
S
EV
L
A
FV
SKPPA
E
AV
RL
KI
VNAM
KA
T
GKP
T
VA
L
FLG
YT
P
AVARDE
NV
W
FA
SSLD
EAA
RL
A
C
L
L
---
------------SRV
T
VRR
NA
IA
--
PVSSGF
I
C
GL
Y
T
GGTL
A
A
EA
AG
LL
AGHL
G
VE
A
-
--
---
D
DTHQ
H
GM
M
LD
A
DS
H
Q
I
I
D
L
GDD
FY
T
V
G
R
PHPMIDPTLRN
Q
LI
A
D
L
GA
K
P
Q
V
R
VLL
L
D
V
V
I
GFGA
TA
DPA
A
SLV
S
A
WQ
KA
C
A
-
A
RL
DN
Q
PL
YA
IA
T
V
T
GTE
R
DPQ
C
RSQQI
AT
L
E
DAG
IA
V
V
SS
LPE
A
T
LLAAALI
fig|749538.3.peg.2569
Escherichia coli MS 116-1 (6-493/555)
IK
K
G
C
F
QDSVSLM
I
IS
R
K
L
S
ES
E
N
VD
DV
SV
M
MGTP
A
NK
AL
L
DTT
G
F
WHDDFN
NA
T
PND
I
C
V
AI
R
S
E
AADA
GI
A
Q
AI
-
M
QQL
EE
A
L
K
Q
LAQG
SG
--
S
S
Q
AL
M
QVRR
WD
SA
C
Q
KL
P
D
ANLALISV
A
G
E
YAA
E
L
A
N
QAL
DRN
LNVMMFSDNV
T
LEDE
IQ
LKT
R
AREKGLLVMGPDCGT
SM
I
A
G
T
PL
A
FANV
M
P
E
GNIGVIGASGTG
I
QEL
CS
Q
I
ALA
G
E
GI
TH
AIG
L
GGRDLS
R
E
V
GGIS
A
L
T
AL
E
ML
SA
D
E
K
S
EV
L
A
FV
SKPPA
E
AV
RL
KI
VNAM
KA
T
GKP
T
VA
L
FLG
YT
P
AVARDE
NV
W
FA
SSLD
EAA
RL
A
C
L
L
---
------------SRV
T
ARR
NA
IA
--
PVSSGF
I
C
GL
Y
T
GGTL
A
A
EA
AG
LL
AGHL
G
VE
A
-
--
---
D
DTHQ
H
GM
M
LD
A
DS
H
Q
I
I
D
L
GDD
FY
T
V
G
R
PHPMIDPTLRN
Q
LI
A
D
L
GA
K
P
Q
V
R
VLL
L
D
V
V
I
GFGA
TA
DPA
A
SLV
S
A
WQ
KA
C
A
-
A
RL
DN
Q
PL
YA
IA
T
V
T
GTE
R
DPQ
C
RSQQI
AT
L
E
DAG
IA
V
V
SS
LPE
A
T
LLAAALI
fig|749544.3.peg.263
Escherichia coli MS 175-1 (6-493/555)
IK
K
G
C
F
QDSVSLM
I
IS
R
K
L
S
ES
E
N
VD
DV
SV
M
MGTP
A
NK
AL
L
DTT
G
F
WHDDFN
NA
T
PND
I
C
V
AI
R
S
E
AADA
GI
A
Q
AI
-
M
QQL
EE
A
L
K
Q
LAQG
SG
--
S
S
Q
AL
M
QVRR
WD
SA
C
Q
KL
P
D
ANLALISV
A
G
E
YAA
E
L
A
N
QAL
DRN
LNVMMFSDNV
T
LEDE
IQ
LKT
R
AREKGLLVMGPDCGT
SM
I
A
G
T
PL
A
FANV
M
P
E
GNIGVIGASGTG
I
QEL
CS
Q
I
ALA
G
E
GI
TH
AIG
L
GGRDLS
R
E
V
GGIS
A
L
T
AL
E
ML
SA
D
E
K
S
EV
L
A
FV
SKPPA
E
AV
RL
KI
VNAM
KA
T
GKP
T
VA
L
FLG
YT
P
AVARDE
NV
W
FA
SSLD
EAA
RL
A
C
L
L
---
------------SRV
T
ARR
NA
IA
--
PVSSGF
I
C
GL
Y
T
GGTL
A
A
EA
AG
LL
AGHL
G
VE
A
-
--
---
D
DTHQ
H
GM
M
LD
A
DS
H
Q
I
I
D
L
GDD
FY
T
V
G
R
PHPMIDPTLRN
Q
LI
A
D
L
GA
K
P
Q
V
R
VLL
L
D
V
V
I
GFGA
TA
DPA
A
SLV
S
A
WQ
KA
C
A
-
A
RL
DN
Q
PL
YA
IA
T
V
T
GTE
R
DPQ
C
RSQQI
AT
L
E
DAG
IA
V
V
SS
LPE
A
T
LLAAALI
fig|595496.3.peg.440
Escherichia coli BW2952 (6-493/555)
IK
K
G
C
F
QDSVSLM
I
IS
R
K
L
S
ES
E
N
VD
DV
SV
M
MGTP
A
NK
AL
L
DTT
G
F
WHDDFN
NA
T
PND
I
C
V
AI
R
S
E
AADA
GI
A
Q
AI
-
M
QQL
EE
A
L
K
Q
LAQG
SG
--
S
S
Q
AL
T
QVRR
WD
SA
C
Q
KL
P
D
ANLALISV
A
G
E
YAA
E
L
A
N
QAL
DRN
LNVMMFSDNV
T
LEDE
IQ
LKT
R
AREKGLLVMGPDCGT
SM
I
A
G
T
PL
A
FANV
M
P
E
GNIGVIGASGTG
I
QEL
CS
Q
I
ALA
G
E
GI
TH
AIG
L
GGRDLS
R
E
V
GGIS
A
L
T
AL
E
ML
SA
D
E
K
S
EV
L
A
FV
SKPPA
E
AV
RL
KI
VNAM
KA
T
GKP
T
VA
L
FLG
YT
P
AVARDE
NV
W
FA
SSLD
EAA
RL
A
C
L
L
---
------------SRV
T
ARR
NA
IA
--
PVSSGF
I
C
GL
Y
T
GGTL
A
A
EA
AG
LL
AGHL
G
VE
A
-
--
---
D
DTHQ
H
GM
M
LD
A
DS
H
Q
I
I
D
L
GDD
FY
T
V
G
R
PHPMIDPTLRN
Q
LI
A
D
L
GA
K
P
Q
V
R
VLL
L
D
V
V
I
GFGA
TA
DPA
A
SLV
S
A
WQ
KA
C
A
-
A
RL
DN
Q
PL
YA
IA
T
V
T
GTE
R
DPQ
C
RSQQI
AT
L
E
DAG
IA
V
V
SS
LPE
A
T
LLAAALI
fig|536056.3.peg.3270
Escherichia coli DH1 (6-493/555)
IK
K
G
C
F
QDSVSLM
I
IS
R
K
L
S
ES
E
N
VD
DV
SV
M
MGTP
A
NK
AL
L
DTT
G
F
WHDDFN
NA
T
PND
I
C
V
AI
R
S
E
AADA
GI
A
Q
AI
-
M
QQL
EE
A
L
K
Q
LAQG
SG
--
S
S
Q
AL
T
QVRR
WD
SA
C
Q
KL
P
D
ANLALISV
A
G
E
YAA
E
L
A
N
QAL
DRN
LNVMMFSDNV
T
LEDE
IQ
LKT
R
AREKGLLVMGPDCGT
SM
I
A
G
T
PL
A
FANV
M
P
E
GNIGVIGASGTG
I
QEL
CS
Q
I
ALA
G
E
GI
TH
AIG
L
GGRDLS
R
E
V
GGIS
A
L
T
AL
E
ML
SA
D
E
K
S
EV
L
A
FV
SKPPA
E
AV
RL
KI
VNAM
KA
T
GKP
T
VA
L
FLG
YT
P
AVARDE
NV
W
FA
SSLD
EAA
RL
A
C
L
L
---
------------SRV
T
ARR
NA
IA
--
PVSSGF
I
C
GL
Y
T
GGTL
A
A
EA
AG
LL
AGHL
G
VE
A
-
--
---
D
DTHQ
H
GM
M
LD
A
DS
H
Q
I
I
D
L
GDD
FY
T
V
G
R
PHPMIDPTLRN
Q
LI
A
D
L
GA
K
P
Q
V
R
VLL
L
D
V
V
I
GFGA
TA
DPA
A
SLV
S
A
WQ
KA
C
A
-
A
RL
DN
Q
PL
YA
IA
T
V
T
GTE
R
DPQ
C
RSQQI
AT
L
E
DAG
IA
V
V
SS
LPE
A
T
LLAAALI
fig|316401.4.peg.655
Escherichia coli ETEC H10407 (6-493/555)
IK
K
G
C
F
QDSVSLM
I
IS
R
K
L
S
ES
E
N
VD
DV
SV
M
MGTP
A
NK
AL
L
DTT
G
F
WHDDFN
NA
T
PND
I
C
V
AI
R
S
E
AADA
GI
A
Q
AI
-
M
QQL
EE
A
L
K
Q
LAQG
SG
--
S
S
Q
AL
T
QVRR
WD
SA
C
Q
KL
P
D
ANLALISV
A
G
E
YAA
E
L
A
N
QAL
DRN
LNVMMFSDNV
T
LEDE
IQ
LKT
R
AREKGLLVMGPDCGT
SM
I
A
G
T
PL
A
FANV
M
P
E
GNIGVIGASGTG
I
QEL
CS
Q
I
ALA
G
E
GI
TH
AIG
L
GGRDLS
R
E
V
GGIS
A
L
T
AL
E
ML
SA
D
E
K
S
EV
L
A
FV
SKPPA
E
AV
RL
KI
VNAM
KA
T
GKP
T
VA
L
FLG
YT
P
AVARDE
NV
W
FA
SSLD
EAA
RL
A
C
L
L
---
------------SRV
T
ARR
NA
IA
--
PVSSGF
I
C
GL
Y
T
GGTL
A
A
EA
AG
LL
AGHL
G
VE
A
-
--
---
D
DTHQ
H
GM
M
LD
A
DS
H
Q
I
I
D
L
GDD
FY
T
V
G
R
PHPMIDPTLRN
Q
LI
A
D
L
GA
K
P
Q
V
R
VLL
L
D
V
V
I
GFGA
TA
DPA
A
SLV
S
A
WQ
KA
C
A
-
A
RL
DN
Q
PL
YA
IA
T
V
T
GTE
R
DPQ
C
RSQQI
AT
L
E
DAG
IA
V
V
SS
LPE
A
T
LLAAALI
fig|83333.1.peg.514
Escherichia coli K12 (6-493/555)
IK
K
G
C
F
QDSVSLM
I
IS
R
K
L
S
ES
E
N
VD
DV
SV
M
MGTP
A
NK
AL
L
DTT
G
F
WHDDFN
NA
T
PND
I
C
V
AI
R
S
E
AADA
GI
A
Q
AI
-
M
QQL
EE
A
L
K
Q
LAQG
SG
--
S
S
Q
AL
T
QVRR
WD
SA
C
Q
KL
P
D
ANLALISV
A
G
E
YAA
E
L
A
N
QAL
DRN
LNVMMFSDNV
T
LEDE
IQ
LKT
R
AREKGLLVMGPDCGT
SM
I
A
G
T
PL
A
FANV
M
P
E
GNIGVIGASGTG
I
QEL
CS
Q
I
ALA
G
E
GI
TH
AIG
L
GGRDLS
R
E
V
GGIS
A
L
T
AL
E
ML
SA
D
E
K
S
EV
L
A
FV
SKPPA
E
AV
RL
KI
VNAM
KA
T
GKP
T
VA
L
FLG
YT
P
AVARDE
NV
W
FA
SSLD
EAA
RL
A
C
L
L
---
------------SRV
T
ARR
NA
IA
--
PVSSGF
I
C
GL
Y
T
GGTL
A
A
EA
AG
LL
AGHL
G
VE
A
-
--
---
D
DTHQ
H
GM
M
LD
A
DS
H
Q
I
I
D
L
GDD
FY
T
V
G
R
PHPMIDPTLRN
Q
LI
A
D
L
GA
K
P
Q
V
R
VLL
L
D
V
V
I
GFGA
TA
DPA
A
SLV
S
A
WQ
KA
C
A
-
A
RL
DN
Q
PL
YA
IA
T
V
T
GTE
R
DPQ
C
RSQQI
AT
L
E
DAG
IA
V
V
SS
LPE
A
T
LLAAALI
fig|316407.3.peg.502
Escherichia coli W3110 (6-493/555)
IK
K
G
C
F
QDSVSLM
I
IS
R
K
L
S
ES
E
N
VD
DV
SV
M
MGTP
A
NK
AL
L
DTT
G
F
WHDDFN
NA
T
PND
I
C
V
AI
R
S
E
AADA
GI
A
Q
AI
-
M
QQL
EE
A
L
K
Q
LAQG
SG
--
S
S
Q
AL
T
QVRR
WD
SA
C
Q
KL
P
D
ANLALISV
A
G
E
YAA
E
L
A
N
QAL
DRN
LNVMMFSDNV
T
LEDE
IQ
LKT
R
AREKGLLVMGPDCGT
SM
I
A
G
T
PL
A
FANV
M
P
E
GNIGVIGASGTG
I
QEL
CS
Q
I
ALA
G
E
GI
TH
AIG
L
GGRDLS
R
E
V
GGIS
A
L
T
AL
E
ML
SA
D
E
K
S
EV
L
A
FV
SKPPA
E
AV
RL
KI
VNAM
KA
T
GKP
T
VA
L
FLG
YT
P
AVARDE
NV
W
FA
SSLD
EAA
RL
A
C
L
L
---
------------SRV
T
ARR
NA
IA
--
PVSSGF
I
C
GL
Y
T
GGTL
A
A
EA
AG
LL
AGHL
G
VE
A
-
--
---
D
DTHQ
H
GM
M
LD
A
DS
H
Q
I
I
D
L
GDD
FY
T
V
G
R
PHPMIDPTLRN
Q
LI
A
D
L
GA
K
P
Q
V
R
VLL
L
D
V
V
I
GFGA
TA
DPA
A
SLV
S
A
WQ
KA
C
A
-
A
RL
DN
Q
PL
YA
IA
T
V
T
GTE
R
DPQ
C
RSQQI
AT
L
E
DAG
IA
V
V
SS
LPE
A
T
LLAAALI
fig|316385.5.peg.473
Escherichia coli str. K-12 substr. DH10B (6-493/555)
IK
K
G
C
F
QDSVSLM
I
IS
R
K
L
S
ES
E
N
VD
DV
SV
M
MGTP
A
NK
AL
L
DTT
G
F
WHDDFN
NA
T
PND
I
C
V
AI
R
S
E
AADA
GI
A
Q
AI
-
M
QQL
EE
A
L
K
Q
LAQG
SG
--
S
S
Q
AL
T
QVRR
WD
SA
C
Q
KL
P
D
ANLALISV
A
G
E
YAA
E
L
A
N
QAL
DRN
LNVMMFSDNV
T
LEDE
IQ
LKT
R
AREKGLLVMGPDCGT
SM
I
A
G
T
PL
A
FANV
M
P
E
GNIGVIGASGTG
I
QEL
CS
Q
I
ALA
G
E
GI
TH
AIG
L
GGRDLS
R
E
V
GGIS
A
L
T
AL
E
ML
SA
D
E
K
S
EV
L
A
FV
SKPPA
E
AV
RL
KI
VNAM
KA
T
GKP
T
VA
L
FLG
YT
P
AVARDE
NV
W
FA
SSLD
EAA
RL
A
C
L
L
---
------------SRV
T
ARR
NA
IA
--
PVSSGF
I
C
GL
Y
T
GGTL
A
A
EA
AG
LL
AGHL
G
VE
A
-
--
---
D
DTHQ
H
GM
M
LD
A
DS
H
Q
I
I
D
L
GDD
FY
T
V
G
R
PHPMIDPTLRN
Q
LI
A
D
L
GA
K
P
Q
V
R
VLL
L
D
V
V
I
GFGA
TA
DPA
A
SLV
S
A
WQ
KA
C
A
-
A
RL
DN
Q
PL
YA
IA
T
V
T
GTE
R
DPQ
C
RSQQI
AT
L
E
DAG
IA
V
V
SS
LPE
A
T
LLAAALI
fig|316385.7.peg.480
Escherichia coli str. K-12 substr. DH10B (6-493/555)
IK
K
G
C
F
QDSVSLM
I
IS
R
K
L
S
ES
E
N
VD
DV
SV
M
MGTP
A
NK
AL
L
DTT
G
F
WHDDFN
NA
T
PND
I
C
V
AI
R
S
E
AADA
GI
A
Q
AI
-
M
QQL
EE
A
L
K
Q
LAQG
SG
--
S
S
Q
AL
T
QVRR
WD
SA
C
Q
KL
P
D
ANLALISV
A
G
E
YAA
E
L
A
N
QAL
DRN
LNVMMFSDNV
T
LEDE
IQ
LKT
R
AREKGLLVMGPDCGT
SM
I
A
G
T
PL
A
FANV
M
P
E
GNIGVIGASGTG
I
QEL
CS
Q
I
ALA
G
E
GI
TH
AIG
L
GGRDLS
R
E
V
GGIS
A
L
T
AL
E
ML
SA
D
E
K
S
EV
L
A
FV
SKPPA
E
AV
RL
KI
VNAM
KA
T
GKP
T
VA
L
FLG
YT
P
AVARDE
NV
W
FA
SSLD
EAA
RL
A
C
L
L
---
------------SRV
T
ARR
NA
IA
--
PVSSGF
I
C
GL
Y
T
GGTL
A
A
EA
AG
LL
AGHL
G
VE
A
-
--
---
D
DTHQ
H
GM
M
LD
A
DS
H
Q
I
I
D
L
GDD
FY
T
V
G
R
PHPMIDPTLRN
Q
LI
A
D
L
GA
K
P
Q
V
R
VLL
L
D
V
V
I
GFGA
TA
DPA
A
SLV
S
A
WQ
KA
C
A
-
A
RL
DN
Q
PL
YA
IA
T
V
T
GTE
R
DPQ
C
RSQQI
AT
L
E
DAG
IA
V
V
SS
LPE
A
T
LLAAALI
fig|511145.12.peg.538
Escherichia coli str. K-12 substr. MG1655 (6-493/555)
IK
K
G
C
F
QDSVSLM
I
IS
R
K
L
S
ES
E
N
VD
DV
SV
M
MGTP
A
NK
AL
L
DTT
G
F
WHDDFN
NA
T
PND
I
C
V
AI
R
S
E
AADA
GI
A
Q
AI
-
M
QQL
EE
A
L
K
Q
LAQG
SG
--
S
S
Q
AL
T
QVRR
WD
SA
C
Q
KL
P
D
ANLALISV
A
G
E
YAA
E
L
A
N
QAL
DRN
LNVMMFSDNV
T
LEDE
IQ
LKT
R
AREKGLLVMGPDCGT
SM
I
A
G
T
PL
A
FANV
M
P
E
GNIGVIGASGTG
I
QEL
CS
Q
I
ALA
G
E
GI
TH
AIG
L
GGRDLS
R
E
V
GGIS
A
L
T
AL
E
ML
SA
D
E
K
S
EV
L
A
FV
SKPPA
E
AV
RL
KI
VNAM
KA
T
GKP
T
VA
L
FLG
YT
P
AVARDE
NV
W
FA
SSLD
EAA
RL
A
C
L
L
---
------------SRV
T
ARR
NA
IA
--
PVSSGF
I
C
GL
Y
T
GGTL
A
A
EA
AG
LL
AGHL
G
VE
A
-
--
---
D
DTHQ
H
GM
M
LD
A
DS
H
Q
I
I
D
L
GDD
FY
T
V
G
R
PHPMIDPTLRN
Q
LI
A
D
L
GA
K
P
Q
V
R
VLL
L
D
V
V
I
GFGA
TA
DPA
A
SLV
S
A
WQ
KA
C
A
-
A
RL
DN
Q
PL
YA
IA
T
V
T
GTE
R
DPQ
C
RSQQI
AT
L
E
DAG
IA
V
V
SS
LPE
A
T
LLAAALI
fig|511145.6.peg.532
Escherichia coli str. K-12 substr. MG1655 (6-493/555)
IK
K
G
C
F
QDSVSLM
I
IS
R
K
L
S
ES
E
N
VD
DV
SV
M
MGTP
A
NK
AL
L
DTT
G
F
WHDDFN
NA
T
PND
I
C
V
AI
R
S
E
AADA
GI
A
Q
AI
-
M
QQL
EE
A
L
K
Q
LAQG
SG
--
S
S
Q
AL
T
QVRR
WD
SA
C
Q
KL
P
D
ANLALISV
A
G
E
YAA
E
L
A
N
QAL
DRN
LNVMMFSDNV
T
LEDE
IQ
LKT
R
AREKGLLVMGPDCGT
SM
I
A
G
T
PL
A
FANV
M
P
E
GNIGVIGASGTG
I
QEL
CS
Q
I
ALA
G
E
GI
TH
AIG
L
GGRDLS
R
E
V
GGIS
A
L
T
AL
E
ML
SA
D
E
K
S
EV
L
A
FV
SKPPA
E
AV
RL
KI
VNAM
KA
T
GKP
T
VA
L
FLG
YT
P
AVARDE
NV
W
FA
SSLD
EAA
RL
A
C
L
L
---
------------SRV
T
ARR
NA
IA
--
PVSSGF
I
C
GL
Y
T
GGTL
A
A
EA
AG
LL
AGHL
G
VE
A
-
--
---
D
DTHQ
H
GM
M
LD
A
DS
H
Q
I
I
D
L
GDD
FY
T
V
G
R
PHPMIDPTLRN
Q
LI
A
D
L
GA
K
P
Q
V
R
VLL
L
D
V
V
I
GFGA
TA
DPA
A
SLV
S
A
WQ
KA
C
A
-
A
RL
DN
Q
PL
YA
IA
T
V
T
GTE
R
DPQ
C
RSQQI
AT
L
E
DAG
IA
V
V
SS
LPE
A
T
LLAAALI
fig|562.371.peg.2788
Escherichia coli 1044A (6-493/555)
IK
K
G
C
F
QDSVSLM
I
IS
R
K
L
S
ES
E
N
VD
DV
SV
M
MGTP
A
NK
AL
L
DTT
G
F
WHDDFN
NA
T
PND
I
C
V
AI
R
S
E
AADA
GI
A
Q
AI
-
M
QQL
EE
A
L
K
Q
LAQG
SG
--
S
S
Q
AL
T
QVRR
WD
SA
C
Q
KL
P
D
ANLALISV
A
G
E
YAA
E
L
A
N
QAL
DRN
LNVMMFSDNV
T
LEDE
IQ
LKT
R
AREKGLLVMGPDCGT
SM
I
A
G
T
PL
A
FANV
M
P
E
GNIGVIGASGTG
I
QEL
CS
Q
I
ALA
G
E
GI
TH
AIG
L
GGRDLS
R
E
V
GGIS
A
L
T
AL
E
ML
SA
D
E
K
S
EV
L
A
FV
SKPPA
E
AV
RL
KI
VNAM
KA
T
GKP
T
VA
L
FLG
YT
P
AVARDE
NV
W
FA
SSLD
EAA
RL
A
C
L
L
---
------------SRV
T
ARR
NA
IM
--
PASSGF
I
C
GL
Y
T
GGTL
A
A
EA
AG
LL
AGHL
G
VE
A
-
--
---
D
DAHH
H
GM
M
LD
A
DG
H
Q
I
I
D
L
GDD
FY
T
V
G
R
PHPMIDPTLRN
Q
LI
T
D
L
GA
K
P
Q
V
R
VLL
L
D
V
V
I
GFGA
TA
DPA
A
SLV
S
A
WQ
KA
C
A
-
A
RS
DN
Q
PL
YA
IA
T
V
T
GTE
R
DPQ
C
RSQQI
AT
L
E
DAG
IA
V
V
SS
LPE
A
T
LLAAALI
fig|562.372.peg.1520
Escherichia coli 1212A (6-493/555)
IK
K
G
C
F
QDSVSLM
I
IS
R
K
L
S
ES
E
N
VD
DV
SV
M
MGTP
A
NK
AL
L
DTT
G
F
WHDDFN
NA
T
PND
I
C
V
AI
R
S
E
AADA
GI
A
Q
AI
-
M
QQL
EE
A
L
K
Q
LAQG
SG
--
S
S
Q
AL
T
QVRR
WD
SA
C
Q
KL
P
D
ANLALISV
A
G
E
YAA
E
L
A
N
QAL
DRN
LNVMMFSDNV
T
LEDE
IQ
LKT
R
AREKGLLVMGPDCGT
SM
I
A
G
T
PL
A
FANV
M
P
E
GNIGVIGASGTG
I
QEL
CS
Q
I
ALA
G
E
GI
TH
AIG
L
GGRDLS
R
E
V
GGIS
A
L
T
AL
E
ML
SA
D
E
K
S
EV
L
A
FV
SKPPA
E
AV
RL
KI
VNAM
KA
T
GKP
T
VA
L
FLG
YT
P
AVARDE
NV
W
FA
SSLD
EAA
RL
A
C
L
L
---
------------SRV
T
ARR
NA
IM
--
PASSGF
I
C
GL
Y
T
GGTL
A
A
EA
AG
LL
AGHL
G
VE
A
-
--
---
D
DAHH
H
GM
M
LD
A
DG
H
Q
I
I
D
L
GDD
FY
T
V
G
R
PHPMIDPTLRN
Q
LI
T
D
L
GA
K
P
Q
V
R
VLL
L
D
V
V
I
GFGA
TA
DPA
A
SLV
S
A
WQ
KA
C
A
-
A
RS
DN
Q
PL
YA
IA
T
V
T
GTE
R
DPQ
C
RSQQI
AT
L
E
DAG
IA
V
V
SS
LPE
A
T
LLAAALI
fig|562.374.peg.5456
Escherichia coli 536A (6-493/555)
IK
K
G
C
F
QDSVSLM
I
IS
R
K
L
S
ES
E
N
VD
DV
SV
M
MGTP
A
NK
AL
L
DTT
G
F
WHDDFN
NA
T
PND
I
C
V
AI
R
S
E
AADA
GI
A
Q
AI
-
M
QQL
EE
A
L
K
Q
LAQG
SG
--
S
S
Q
AL
T
QVRR
WD
SA
C
Q
KL
P
D
ANLALISV
A
G
E
YAA
E
L
A
N
QAL
DRN
LNVMMFSDNV
T
LEDE
IQ
LKT
R
AREKGLLVMGPDCGT
SM
I
A
G
T
PL
A
FANV
M
P
E
GNIGVIGASGTG
I
QEL
CS
Q
I
ALA
G
E
GI
TH
AIG
L
GGRDLS
R
E
V
GGIS
A
L
T
AL
E
ML
SA
D
E
K
S
EV
L
A
FV
SKPPA
E
AV
RL
KI
VNAM
KA
T
GKP
T
VA
L
FLG
YT
P
AVARDE
NV
W
FA
SSLD
EAA
RL
A
C
L
L
---
------------SRV
T
ARR
NA
IM
--
PASSGF
I
C
GL
Y
T
GGTL
A
A
EA
AG
LL
AGHL
G
VE
A
-
--
---
D
DAHH
H
GM
M
LD
A
DG
H
Q
I
I
D
L
GDD
FY
T
V
G
R
PHPMIDPTLRN
Q
LI
T
D
L
GA
K
P
Q
V
R
VLL
L
D
V
V
I
GFGA
TA
DPA
A
SLV
S
A
WQ
KA
C
A
-
A
RS
DN
Q
PL
YA
IA
T
V
T
GTE
R
DPQ
C
RSQQI
AT
L
E
DAG
IA
V
V
SS
LPE
A
T
LLAAALI
fig|83334.1.peg.652
Escherichia coli O157:H7 (6-493/555)
IK
K
G
C
F
QDSVSLM
I
IS
R
K
L
S
ES
E
N
VD
DV
SV
M
MGTP
A
NK
AL
L
DTT
G
F
WHDDFN
NA
T
PND
I
C
V
AI
R
S
E
AADA
GI
A
Q
AI
-
M
QQL
EE
A
L
K
Q
LAQG
SG
--
S
S
Q
AL
T
QVRR
WD
SA
C
Q
KL
P
D
ANLALISV
A
G
E
YAA
E
L
A
N
QAL
DRN
LNVMMFSDNV
T
LEDE
IQ
LKT
R
AREKGLLVMGPDCGT
SM
I
A
G
T
PL
A
FANV
M
P
E
GNIGVIGASGTG
I
QEL
CS
Q
I
ALA
G
E
GI
TH
AIG
L
GGRDLS
R
E
V
GGIS
A
L
T
AL
E
ML
SA
D
E
K
S
EV
L
A
FV
SKPPA
E
AV
RL
KI
VNAM
KA
T
GKP
T
VA
L
FLG
YT
P
AVARDE
NV
W
FA
SSLD
EAA
RL
A
C
L
L
---
------------SRV
T
ARR
NA
IM
--
PASSGF
I
C
GL
Y
T
GGTL
A
A
EA
AG
LL
AGHL
G
VE
A
-
--
---
D
DAHH
H
GM
M
LD
A
DG
H
Q
I
I
D
L
GDD
FY
T
V
G
R
PHPMIDPTLRN
Q
LI
T
D
L
GA
K
P
Q
V
R
VLL
L
D
V
V
I
GFGA
TA
DPA
A
SLV
S
A
WQ
KA
C
A
-
A
RS
DN
Q
PL
YA
IA
T
V
T
GTE
R
DPQ
C
RSQQI
AT
L
E
DAG
IA
V
V
SS
LPE
A
T
LLAAALI
fig|155864.1.peg.575
Escherichia coli O157:H7 EDL933 (6-493/555)
IK
K
G
C
F
QDSVSLM
I
IS
R
K
L
S
ES
E
N
VD
DV
SV
M
MGTP
A
NK
AL
L
DTT
G
F
WHDDFN
NA
T
PND
I
C
V
AI
R
S
E
AADA
GI
A
Q
AI
-
M
QQL
EE
A
L
K
Q
LAQG
SG
--
S
S
Q
AL
T
QVRR
WD
SA
C
Q
KL
P
D
ANLALISV
A
G
E
YAA
E
L
A
N
QAL
DRN
LNVMMFSDNV
T
LEDE
IQ
LKT
R
AREKGLLVMGPDCGT
SM
I
A
G
T
PL
A
FANV
M
P
E
GNIGVIGASGTG
I
QEL
CS
Q
I
ALA
G
E
GI
TH
AIG
L
GGRDLS
R
E
V
GGIS
A
L
T
AL
E
ML
SA
D
E
K
S
EV
L
A
FV
SKPPA
E
AV
RL
KI
VNAM
KA
T
GKP
T
VA
L
FLG
YT
P
AVARDE
NV
W
FA
SSLD
EAA
RL
A
C
L
L
---
------------SRV
T
ARR
NA
IM
--
PASSGF
I
C
GL
Y
T
GGTL
A
A
EA
AG
LL
AGHL
G
VE
A
-
--
---
D
DAHH
H
GM
M
LD
A
DG
H
Q
I
I
D
L
GDD
FY
T
V
G
R
PHPMIDPTLRN
Q
LI
T
D
L
GA
K
P
Q
V
R
VLL
L
D
V
V
I
GFGA
TA
DPA
A
SLV
S
A
WQ
KA
C
A
-
A
RS
DN
Q
PL
YA
IA
T
V
T
GTE
R
DPQ
C
RSQQI
AT
L
E
DAG
IA
V
V
SS
LPE
A
T
LLAAALI
fig|155864.8.peg.589
Escherichia coli O157:H7 EDL933 (6-493/555)
IK
K
G
C
F
QDSVSLM
I
IS
R
K
L
S
ES
E
N
VD
DV
SV
M
MGTP
A
NK
AL
L
DTT
G
F
WHDDFN
NA
T
PND
I
C
V
AI
R
S
E
AADA
GI
A
Q
AI
-
M
QQL
EE
A
L
K
Q
LAQG
SG
--
S
S
Q
AL
T
QVRR
WD
SA
C
Q
KL
P
D
ANLALISV
A
G
E
YAA
E
L
A
N
QAL
DRN
LNVMMFSDNV
T
LEDE
IQ
LKT
R
AREKGLLVMGPDCGT
SM
I
A
G
T
PL
A
FANV
M
P
E
GNIGVIGASGTG
I
QEL
CS
Q
I
ALA
G
E
GI
TH
AIG
L
GGRDLS
R
E
V
GGIS
A
L
T
AL
E
ML
SA
D
E
K
S
EV
L
A
FV
SKPPA
E
AV
RL
KI
VNAM
KA
T
GKP
T
VA
L
FLG
YT
P
AVARDE
NV
W
FA
SSLD
EAA
RL
A
C
L
L
---
------------SRV
T
ARR
NA
IM
--
PASSGF
I
C
GL
Y
T
GGTL
A
A
EA
AG
LL
AGHL
G
VE
A
-
--
---
D
DAHH
H
GM
M
LD
A
DG
H
Q
I
I
D
L
GDD
FY
T
V
G
R
PHPMIDPTLRN
Q
LI
T
D
L
GA
K
P
Q
V
R
VLL
L
D
V
V
I
GFGA
TA
DPA
A
SLV
S
A
WQ
KA
C
A
-
A
RS
DN
Q
PL
YA
IA
T
V
T
GTE
R
DPQ
C
RSQQI
AT
L
E
DAG
IA
V
V
SS
LPE
A
T
LLAAALI
fig|444454.5.peg.5064
Escherichia coli O157:H7 str. EC4024 (6-493/555)
IK
K
G
C
F
QDSVSLM
I
IS
R
K
L
S
ES
E
N
VD
DV
SV
M
MGTP
A
NK
AL
L
DTT
G
F
WHDDFN
NA
T
PND
I
C
V
AI
R
S
E
AADA
GI
A
Q
AI
-
M
QQL
EE
A
L
K
Q
LAQG
SG
--
S
S
Q
AL
T
QVRR
WD
SA
C
Q
KL
P
D
ANLALISV
A
G
E
YAA
E
L
A
N
QAL
DRN
LNVMMFSDNV
T
LEDE
IQ
LKT
R
AREKGLLVMGPDCGT
SM
I
A
G
T
PL
A
FANV
M
P
E
GNIGVIGASGTG
I
QEL
CS
Q
I
ALA
G
E
GI
TH
AIG
L
GGRDLS
R
E
V
GGIS
A
L
T
AL
E
ML
SA
D
E
K
S
EV
L
A
FV
SKPPA
E
AV
RL
KI
VNAM
KA
T
GKP
T
VA
L
FLG
YT
P
AVARDE
NV
W
FA
SSLD
EAA
RL
A
C
L
L
---
------------SRV
T
ARR
NA
IM
--
PASSGF
I
C
GL
Y
T
GGTL
A
A
EA
AG
LL
AGHL
G
VE
A
-
--
---
D
DAHH
H
GM
M
LD
A
DG
H
Q
I
I
D
L
GDD
FY
T
V
G
R
PHPMIDPTLRN
Q
LI
T
D
L
GA
K
P
Q
V
R
VLL
L
D
V
V
I
GFGA
TA
DPA
A
SLV
S
A
WQ
KA
C
A
-
A
RS
DN
Q
PL
YA
IA
T
V
T
GTE
R
DPQ
C
RSQQI
AT
L
E
DAG
IA
V
V
SS
LPE
A
T
LLAAALI
fig|444449.5.peg.5399
Escherichia coli O157:H7 str. EC4042 (6-493/555)
IK
K
G
C
F
QDSVSLM
I
IS
R
K
L
S
ES
E
N
VD
DV
SV
M
MGTP
A
NK
AL
L
DTT
G
F
WHDDFN
NA
T
PND
I
C
V
AI
R
S
E
AADA
GI
A
Q
AI
-
M
QQL
EE
A
L
K
Q
LAQG
SG
--
S
S
Q
AL
T
QVRR
WD
SA
C
Q
KL
P
D
ANLALISV
A
G
E
YAA
E
L
A
N
QAL
DRN
LNVMMFSDNV
T
LEDE
IQ
LKT
R
AREKGLLVMGPDCGT
SM
I
A
G
T
PL
A
FANV
M
P
E
GNIGVIGASGTG
I
QEL
CS
Q
I
ALA
G
E
GI
TH
AIG
L
GGRDLS
R
E
V
GGIS
A
L
T
AL
E
ML
SA
D
E
K
S
EV
L
A
FV
SKPPA
E
AV
RL
KI
VNAM
KA
T
GKP
T
VA
L
FLG
YT
P
AVARDE
NV
W
FA
SSLD
EAA
RL
A
C
L
L
---
------------SRV
T
ARR
NA
IM
--
PASSGF
I
C
GL
Y
T
GGTL
A
A
EA
AG
LL
AGHL
G
VE
A
-
--
---
D
DAHH
H
GM
M
LD
A
DG
H
Q
I
I
D
L
GDD
FY
T
V
G
R
PHPMIDPTLRN
Q
LI
T
D
L
GA
K
P
Q
V
R
VLL
L
D
V
V
I
GFGA
TA
DPA
A
SLV
S
A
WQ
KA
C
A
-
A
RS
DN
Q
PL
YA
IA
T
V
T
GTE
R
DPQ
C
RSQQI
AT
L
E
DAG
IA
V
V
SS
LPE
A
T
LLAAALI
fig|444448.5.peg.3275
Escherichia coli O157:H7 str. EC4045 (6-493/555)
IK
K
G
C
F
QDSVSLM
I
IS
R
K
L
S
ES
E
N
VD
DV
SV
M
MGTP
A
NK
AL
L
DTT
G
F
WHDDFN
NA
T
PND
I
C
V
AI
R
S
E
AADA
GI
A
Q
AI
-
M
QQL
EE
A
L
K
Q
LAQG
SG
--
S
S
Q
AL
T
QVRR
WD
SA
C
Q
KL
P
D
ANLALISV
A
G
E
YAA
E
L
A
N
QAL
DRN
LNVMMFSDNV
T
LEDE
IQ
LKT
R
AREKGLLVMGPDCGT
SM
I
A
G
T
PL
A
FANV
M
P
E
GNIGVIGASGTG
I
QEL
CS
Q
I
ALA
G
E
GI
TH
AIG
L
GGRDLS
R
E
V
GGIS
A
L
T
AL
E
ML
SA
D
E
K
S
EV
L
A
FV
SKPPA
E
AV
RL
KI
VNAM
KA
T
GKP
T
VA
L
FLG
YT
P
AVARDE
NV
W
FA
SSLD
EAA
RL
A
C
L
L
---
------------SRV
T
ARR
NA
IM
--
PASSGF
I
C
GL
Y
T
GGTL
A
A
EA
AG
LL
AGHL
G
VE
A
-
--
---
D
DAHH
H
GM
M
LD
A
DG
H
Q
I
I
D
L
GDD
FY
T
V
G
R
PHPMIDPTLRN
Q
LI
T
D
L
GA
K
P
Q
V
R
VLL
L
D
V
V
I
GFGA
TA
DPA
A
SLV
S
A
WQ
KA
C
A
-
A
RS
DN
Q
PL
YA
IA
T
V
T
GTE
R
DPQ
C
RSQQI
AT
L
E
DAG
IA
V
V
SS
LPE
A
T
LLAAALI
fig|444453.5.peg.616
Escherichia coli O157:H7 str. EC4076 (6-493/555)
IK
K
G
C
F
QDSVSLM
I
IS
R
K
L
S
ES
E
N
VD
DV
SV
M
MGTP
A
NK
AL
L
DTT
G
F
WHDDFN
NA
T
PND
I
C
V
AI
R
S
E
AADA
GI
A
Q
AI
-
M
QQL
EE
A
L
K
Q
LAQG
SG
--
S
S
Q
AL
T
QVRR
WD
SA
C
Q
KL
P
D
ANLALISV
A
G
E
YAA
E
L
A
N
QAL
DRN
LNVMMFSDNV
T
LEDE
IQ
LKT
R
AREKGLLVMGPDCGT
SM
I
A
G
T
PL
A
FANV
M
P
E
GNIGVIGASGTG
I
QEL
CS
Q
I
ALA
G
E
GI
TH
AIG
L
GGRDLS
R
E
V
GGIS
A
L
T
AL
E
ML
SA
D
E
K
S
EV
L
A
FV
SKPPA
E
AV
RL
KI
VNAM
KA
T
GKP
T
VA
L
FLG
YT
P
AVARDE
NV
W
FA
SSLD
EAA
RL
A
C
L
L
---
------------SRV
T
ARR
NA
IM
--
PASSGF
I
C
GL
Y
T
GGTL
A
A
EA
AG
LL
AGHL
G
VE
A
-
--
---
D
DAHH
H
GM
M
LD
A
DG
H
Q
I
I
D
L
GDD
FY
T
V
G
R
PHPMIDPTLRN
Q
LI
T
D
L
GA
K
P
Q
V
R
VLL
L
D
V
V
I
GFGA
TA
DPA
A
SLV
S
A
WQ
KA
C
A
-
A
RS
DN
Q
PL
YA
IA
T
V
T
GTE
R
DPQ
C
RSQQI
AT
L
E
DAG
IA
V
V
SS
LPE
A
T
LLAAALI
fig|444452.5.peg.911
Escherichia coli O157:H7 str. EC4113 (6-493/555)
IK
K
G
C
F
QDSVSLM
I
IS
R
K
L
S
ES
E
N
VD
DV
SV
M
MGTP
A
NK
AL
L
DTT
G
F
WHDDFN
NA
T
PND
I
C
V
AI
R
S
E
AADA
GI
A
Q
AI
-
M
QQL
EE
A
L
K
Q
LAQG
SG
--
S
S
Q
AL
T
QVRR
WD
SA
C
Q
KL
P
D
ANLALISV
A
G
E
YAA
E
L
A
N
QAL
DRN
LNVMMFSDNV
T
LEDE
IQ
LKT
R
AREKGLLVMGPDCGT
SM
I
A
G
T
PL
A
FANV
M
P
E
GNIGVIGASGTG
I
QEL
CS
Q
I
ALA
G
E
GI
TH
AIG
L
GGRDLS
R
E
V
GGIS
A
L
T
AL
E
ML
SA
D
E
K
S
EV
L
A
FV
SKPPA
E
AV
RL
KI
VNAM
KA
T
GKP
T
VA
L
FLG
YT
P
AVARDE
NV
W
FA
SSLD
EAA
RL
A
C
L
L
---
------------SRV
T
ARR
NA
IM
--
PASSGF
I
C
GL
Y
T
GGTL
A
A
EA
AG
LL
AGHL
G
VE
A
-
--
---
D
DAHH
H
GM
M
LD
A
DG
H
Q
I
I
D
L
GDD
FY
T
V
G
R
PHPMIDPTLRN
Q
LI
T
D
L
GA
K
P
Q
V
R
VLL
L
D
V
V
I
GFGA
TA
DPA
A
SLV
S
A
WQ
KA
C
A
-
A
RS
DN
Q
PL
YA
IA
T
V
T
GTE
R
DPQ
C
RSQQI
AT
L
E
DAG
IA
V
V
SS
LPE
A
T
LLAAALI
fig|444450.8.peg.735
Escherichia coli O157:H7 str. EC4115 (6-493/555)
IK
K
G
C
F
QDSVSLM
I
IS
R
K
L
S
ES
E
N
VD
DV
SV
M
MGTP
A
NK
AL
L
DTT
G
F
WHDDFN
NA
T
PND
I
C
V
AI
R
S
E
AADA
GI
A
Q
AI
-
M
QQL
EE
A
L
K
Q
LAQG
SG
--
S
S
Q
AL
T
QVRR
WD
SA
C
Q
KL
P
D
ANLALISV
A
G
E
YAA
E
L
A
N
QAL
DRN
LNVMMFSDNV
T
LEDE
IQ
LKT
R
AREKGLLVMGPDCGT
SM
I
A
G
T
PL
A
FANV
M
P
E
GNIGVIGASGTG
I
QEL
CS
Q
I
ALA
G
E
GI
TH
AIG
L
GGRDLS
R
E
V
GGIS
A
L
T
AL
E
ML
SA
D
E
K
S
EV
L
A
FV
SKPPA
E
AV
RL
KI
VNAM
KA
T
GKP
T
VA
L
FLG
YT
P
AVARDE
NV
W
FA
SSLD
EAA
RL
A
C
L
L
---
------------SRV
T
ARR
NA
IM
--
PASSGF
I
C
GL
Y
T
GGTL
A
A
EA
AG
LL
AGHL
G
VE
A
-
--
---
D
DAHH
H
GM
M
LD
A
DG
H
Q
I
I
D
L
GDD
FY
T
V
G
R
PHPMIDPTLRN
Q
LI
T
D
L
GA
K
P
Q
V
R
VLL
L
D
V
V
I
GFGA
TA
DPA
A
SLV
S
A
WQ
KA
C
A
-
A
RS
DN
Q
PL
YA
IA
T
V
T
GTE
R
DPQ
C
RSQQI
AT
L
E
DAG
IA
V
V
SS
LPE
A
T
LLAAALI
fig|444451.5.peg.2236
Escherichia coli O157:H7 str. EC4196 (6-493/555)
IK
K
G
C
F
QDSVSLM
I
IS
R
K
L
S
ES
E
N
VD
DV
SV
M
MGTP
A
NK
AL
L
DTT
G
F
WHDDFN
NA
T
PND
I
C
V
AI
R
S
E
AADA
GI
A
Q
AI
-
M
QQL
EE
A
L
K
Q
LAQG
SG
--
S
S
Q
AL
T
QVRR
WD
SA
C
Q
KL
P
D
ANLALISV
A
G
E
YAA
E
L
A
N
QAL
DRN
LNVMMFSDNV
T
LEDE
IQ
LKT
R
AREKGLLVMGPDCGT
SM
I
A
G
T
PL
A
FANV
M
P
E
GNIGVIGASGTG
I
QEL
CS
Q
I
ALA
G
E
GI
TH
AIG
L
GGRDLS
R
E
V
GGIS
A
L
T
AL
E
ML
SA
D
E
K
S
EV
L
A
FV
SKPPA
E
AV
RL
KI
VNAM
KA
T
GKP
T
VA
L
FLG
YT
P
AVARDE
NV
W
FA
SSLD
EAA
RL
A
C
L
L
---
------------SRV
T
ARR
NA
IM
--
PASSGF
I
C
GL
Y
T
GGTL
A
A
EA
AG
LL
AGHL
G
VE
A
-
--
---
D
DAHH
H
GM
M
LD
A
DG
H
Q
I
I
D
L
GDD
FY
T
V
G
R
PHPMIDPTLRN
Q
LI
T
D
L
GA
K
P
Q
V
R
VLL
L
D
V
V
I
GFGA
TA
DPA
A
SLV
S
A
WQ
KA
C
A
-
A
RS
DN
Q
PL
YA
IA
T
V
T
GTE
R
DPQ
C
RSQQI
AT
L
E
DAG
IA
V
V
SS
LPE
A
T
LLAAALI
fig|444447.5.peg.3449
Escherichia coli O157:H7 str. EC4206 (6-493/555)
IK
K
G
C
F
QDSVSLM
I
IS
R
K
L
S
ES
E
N
VD
DV
SV
M
MGTP
A
NK
AL
L
DTT
G
F
WHDDFN
NA
T
PND
I
C
V
AI
R
S
E
AADA
GI
A
Q
AI
-
M
QQL
EE
A
L
K
Q
LAQG
SG
--
S
S
Q
AL
T
QVRR
WD
SA
C
Q
KL
P
D
ANLALISV
A
G
E
YAA
E
L
A
N
QAL
DRN
LNVMMFSDNV
T
LEDE
IQ
LKT
R
AREKGLLVMGPDCGT
SM
I
A
G
T
PL
A
FANV
M
P
E
GNIGVIGASGTG
I
QEL
CS
Q
I
ALA
G
E
GI
TH
AIG
L
GGRDLS
R
E
V
GGIS
A
L
T
AL
E
ML
SA
D
E
K
S
EV
L
A
FV
SKPPA
E
AV
RL
KI
VNAM
KA
T
GKP
T
VA
L
FLG
YT
P
AVARDE
NV
W
FA
SSLD
EAA
RL
A
C
L
L
---
------------SRV
T
ARR
NA
IM
--
PASSGF
I
C
GL
Y
T
GGTL
A
A
EA
AG
LL
AGHL
G
VE
A
-
--
---
D
DAHH
H
GM
M
LD
A
DG
H
Q
I
I
D
L
GDD
FY
T
V
G
R
PHPMIDPTLRN
Q
LI
T
D
L
GA
K
P
Q
V
R
VLL
L
D
V
V
I
GFGA
TA
DPA
A
SLV
S
A
WQ
KA
C
A
-
A
RS
DN
Q
PL
YA
IA
T
V
T
GTE
R
DPQ
C
RSQQI
AT
L
E
DAG
IA
V
V
SS
LPE
A
T
LLAAALI
fig|478004.5.peg.1443
Escherichia coli O157:H7 str. EC4401 (6-493/555)
IK
K
G
C
F
QDSVSLM
I
IS
R
K
L
S
ES
E
N
VD
DV
SV
M
MGTP
A
NK
AL
L
DTT
G
F
WHDDFN
NA
T
PND
I
C
V
AI
R
S
E
AADA
GI
A
Q
AI
-
M
QQL
EE
A
L
K
Q
LAQG
SG
--
S
S
Q
AL
T
QVRR
WD
SA
C
Q
KL
P
D
ANLALISV
A
G
E
YAA
E
L
A
N
QAL
DRN
LNVMMFSDNV
T
LEDE
IQ
LKT
R
AREKGLLVMGPDCGT
SM
I
A
G
T
PL
A
FANV
M
P
E
GNIGVIGASGTG
I
QEL
CS
Q
I
ALA
G
E
GI
TH
AIG
L
GGRDLS
R
E
V
GGIS
A
L
T
AL
E
ML
SA
D
E
K
S
EV
L
A
FV
SKPPA
E
AV
RL
KI
VNAM
KA
T
GKP
T
VA
L
FLG
YT
P
AVARDE
NV
W
FA
SSLD
EAA
RL
A
C
L
L
---
------------SRV
T
ARR
NA
IM
--
PASSGF
I
C
GL
Y
T
GGTL
A
A
EA
AG
LL
AGHL
G
VE
A
-
--
---
D
DAHH
H
GM
M
LD
A
DG
H
Q
I
I
D
L
GDD
FY
T
V
G
R
PHPMIDPTLRN
Q
LI
T
D
L
GA
K
P
Q
V
R
VLL
L
D
V
V
I
GFGA
TA
DPA
A
SLV
S
A
WQ
KA
C
A
-
A
RS
DN
Q
PL
YA
IA
T
V
T
GTE
R
DPQ
C
RSQQI
AT
L
E
DAG
IA
V
V
SS
LPE
A
T
LLAAALI
fig|478006.5.peg.872
Escherichia coli O157:H7 str. EC4501 (6-493/555)
IK
K
G
C
F
QDSVSLM
I
IS
R
K
L
S
ES
E
N
VD
DV
SV
M
MGTP
A
NK
AL
L
DTT
G
F
WHDDFN
NA
T
PND
I
C
V
AI
R
S
E
AADA
GI
A
Q
AI
-
M
QQL
EE
A
L
K
Q
LAQG
SG
--
S
S
Q
AL
T
QVRR
WD
SA
C
Q
KL
P
D
ANLALISV
A
G
E
YAA
E
L
A
N
QAL
DRN
LNVMMFSDNV
T
LEDE
IQ
LKT
R
AREKGLLVMGPDCGT
SM
I
A
G
T
PL
A
FANV
M
P
E
GNIGVIGASGTG
I
QEL
CS
Q
I
ALA
G
E
GI
TH
AIG
L
GGRDLS
R
E
V
GGIS
A
L
T
AL
E
ML
SA
D
E
K
S
EV
L
A
FV
SKPPA
E
AV
RL
KI
VNAM
KA
T
GKP
T
VA
L
FLG
YT
P
AVARDE
NV
W
FA
SSLD
EAA
RL
A
C
L
L
---
------------SRV
T
ARR
NA
IM
--
PASSGF
I
C
GL
Y
T
GGTL
A
A
EA
AG
LL
AGHL
G
VE
A
-
--
---
D
DAHH
H
GM
M
LD
A
DG
H
Q
I
I
D
L
GDD
FY
T
V
G
R
PHPMIDPTLRN
Q
LI
T
D
L
GA
K
P
Q
V
R
VLL
L
D
V
V
I
GFGA
TA
DPA
A
SLV
S
A
WQ
KA
C
A
-
A
RS
DN
Q
PL
YA
IA
T
V
T
GTE
R
DPQ
C
RSQQI
AT
L
E
DAG
IA
V
V
SS
LPE
A
T
LLAAALI
fig|478008.5.peg.1675
Escherichia coli O157:H7 str. EC869 (6-493/555)
IK
K
G
C
F
QDSVSLM
I
IS
R
K
L
S
ES
E
N
VD
DV
SV
M
MGTP
A
NK
AL
L
DTT
G
F
WHDDFN
NA
T
PND
I
C
V
AI
R
S
E
AADA
GI
A
Q
AI
-
M
QQL
EE
A
L
K
Q
LAQG
SG
--
S
S
Q
AL
T
QVRR
WD
SA
C
Q
KL
P
D
ANLALISV
A
G
E
YAA
E
L
A
N
QAL
DRN
LNVMMFSDNV
T
LEDE
IQ
LKT
R
AREKGLLVMGPDCGT
SM
I
A
G
T
PL
A
FANV
M
P
E
GNIGVIGASGTG
I
QEL
CS
Q
I
ALA
G
E
GI
TH
AIG
L
GGRDLS
R
E
V
GGIS
A
L
T
AL
E
ML
SA
D
E
K
S
EV
L
A
FV
SKPPA
E
AV
RL
KI
VNAM
KA
T
GKP
T
VA
L
FLG
YT
P
AVARDE
NV
W
FA
SSLD
EAA
RL
A
C
L
L
---
------------SRV
T
ARR
NA
IM
--
PASSGF
I
C
GL
Y
T
GGTL
A
A
EA
AG
LL
AGHL
G
VE
A
-
--
---
D
DAHH
H
GM
M
LD
A
DG
H
Q
I
I
D
L
GDD
FY
T
V
G
R
PHPMIDPTLRN
Q
LI
T
D
L
GA
K
P
Q
V
R
VLL
L
D
V
V
I
GFGA
TA
DPA
A
SLV
S
A
WQ
KA
C
A
-
A
RS
DN
Q
PL
YA
IA
T
V
T
GTE
R
DPQ
C
RSQQI
AT
L
E
DAG
IA
V
V
SS
LPE
A
T
LLAAALI
fig|637388.3.peg.1070
Escherichia coli O157:H7 str. FRIK2000 (6-493/555)
IK
K
G
C
F
QDSVSLM
I
IS
R
K
L
S
ES
E
N
VD
DV
SV
M
MGTP
A
NK
AL
L
DTT
G
F
WHDDFN
NA
T
PND
I
C
V
AI
R
S
E
AADA
GI
A
Q
AI
-
M
QQL
EE
A
L
K
Q
LAQG
SG
--
S
S
Q
AL
T
QVRR
WD
SA
C
Q
KL
P
D
ANLALISV
A
G
E
YAA
E
L
A
N
QAL
DRN
LNVMMFSDNV
T
LEDE
IQ
LKT
R
AREKGLLVMGPDCGT
SM
I
A
G
T
PL
A
FANV
M
P
E
GNIGVIGASGTG
I
QEL
CS
Q
I
ALA
G
E
GI
TH
AIG
L
GGRDLS
R
E
V
GGIS
A
L
T
AL
E
ML
SA
D
E
K
S
EV
L
A
FV
SKPPA
E
AV
RL
KI
VNAM
KA
T
GKP
T
VA
L
FLG
YT
P
AVARDE
NV
W
FA
SSLD
EAA
RL
A
C
L
L
---
------------SRV
T
ARR
NA
IM
--
PASSGF
I
C
GL
Y
T
GGTL
A
A
EA
AG
LL
AGHL
G
VE
A
-
--
---
D
DAHH
H
GM
M
LD
A
DG
H
Q
I
I
D
L
GDD
FY
T
V
G
R
PHPMIDPTLRN
Q
LI
T
D
L
GA
K
P
Q
V
R
VLL
L
D
V
V
I
GFGA
TA
DPA
A
SLV
S
A
WQ
KA
C
A
-
A
RS
DN
Q
PL
YA
IA
T
V
T
GTE
R
DPQ
C
RSQQI
AT
L
E
DAG
IA
V
V
SS
LPE
A
T
LLAAALI
fig|570506.3.peg.3607
Escherichia coli O157:H7 str. FRIK966 (6-493/555)
IK
K
G
C
F
QDSVSLM
I
IS
R
K
L
S
ES
E
N
VD
DV
SV
M
MGTP
A
NK
AL
L
DTT
G
F
WHDDFN
NA
T
PND
I
C
V
AI
R
S
E
AADA
GI
A
Q
AI
-
M
QQL
EE
A
L
K
Q
LAQG
SG
--
S
S
Q
AL
T
QVRR
WD
SA
C
Q
KL
P
D
ANLALISV
A
G
E
YAA
E
L
A
N
QAL
DRN
LNVMMFSDNV
T
LEDE
IQ
LKT
R
AREKGLLVMGPDCGT
SM
I
A
G
T
PL
A
FANV
M
P
E
GNIGVIGASGTG
I
QEL
CS
Q
I
ALA
G
E
GI
TH
AIG
L
GGRDLS
R
E
V
GGIS
A
L
T
AL
E
ML
SA
D
E
K
S
EV
L
A
FV
SKPPA
E
AV
RL
KI
VNAM
KA
T
GKP
T
VA
L
FLG
YT
P
AVARDE
NV
W
FA
SSLD
EAA
RL
A
C
L
L
---
------------SRV
T
ARR
NA
IM
--
PASSGF
I
C
GL
Y
T
GGTL
A
A
EA
AG
LL
AGHL
G
VE
A
-
--
---
D
DAHH
H
GM
M
LD
A
DG
H
Q
I
I
D
L
GDD
FY
T
V
G
R
PHPMIDPTLRN
Q
LI
T
D
L
GA
K
P
Q
V
R
VLL
L
D
V
V
I
GFGA
TA
DPA
A
SLV
S
A
WQ
KA
C
A
-
A
RS
DN
Q
PL
YA
IA
T
V
T
GTE
R
DPQ
C
RSQQI
AT
L
E
DAG
IA
V
V
SS
LPE
A
T
LLAAALI
fig|386585.9.peg.687
Escherichia coli O157:H7 str. Sakai (6-493/555)
IK
K
G
C
F
QDSVSLM
I
IS
R
K
L
S
ES
E
N
VD
DV
SV
M
MGTP
A
NK
AL
L
DTT
G
F
WHDDFN
NA
T
PND
I
C
V
AI
R
S
E
AADA
GI
A
Q
AI
-
M
QQL
EE
A
L
K
Q
LAQG
SG
--
S
S
Q
AL
T
QVRR
WD
SA
C
Q
KL
P
D
ANLALISV
A
G
E
YAA
E
L
A
N
QAL
DRN
LNVMMFSDNV
T
LEDE
IQ
LKT
R
AREKGLLVMGPDCGT
SM
I
A
G
T
PL
A
FANV
M
P
E
GNIGVIGASGTG
I
QEL
CS
Q
I
ALA
G
E
GI
TH
AIG
L
GGRDLS
R
E
V
GGIS
A
L
T
AL
E
ML
SA
D
E
K
S
EV
L
A
FV
SKPPA
E
AV
RL
KI
VNAM
KA
T
GKP
T
VA
L
FLG
YT
P
AVARDE
NV
W
FA
SSLD
EAA
RL
A
C
L
L
---
------------SRV
T
ARR
NA
IM
--
PASSGF
I
C
GL
Y
T
GGTL
A
A
EA
AG
LL
AGHL
G
VE
A
-
--
---
D
DAHH
H
GM
M
LD
A
DG
H
Q
I
I
D
L
GDD
FY
T
V
G
R
PHPMIDPTLRN
Q
LI
T
D
L
GA
K
P
Q
V
R
VLL
L
D
V
V
I
GFGA
TA
DPA
A
SLV
S
A
WQ
KA
C
A
-
A
RS
DN
Q
PL
YA
IA
T
V
T
GTE
R
DPQ
C
RSQQI
AT
L
E
DAG
IA
V
V
SS
LPE
A
T
LLAAALI
fig|544404.4.peg.600
Escherichia coli O157:H7 str. TW14359 (6-493/555)
IK
K
G
C
F
QDSVSLM
I
IS
R
K
L
S
ES
E
N
VD
DV
SV
M
MGTP
A
NK
AL
L
DTT
G
F
WHDDFN
NA
T
PND
I
C
V
AI
R
S
E
AADA
GI
A
Q
AI
-
M
QQL
EE
A
L
K
Q
LAQG
SG
--
S
S
Q
AL
T
QVRR
WD
SA
C
Q
KL
P
D
ANLALISV
A
G
E
YAA
E
L
A
N
QAL
DRN
LNVMMFSDNV
T
LEDE
IQ
LKT
R
AREKGLLVMGPDCGT
SM
I
A
G
T
PL
A
FANV
M
P
E
GNIGVIGASGTG
I
QEL
CS
Q
I
ALA
G
E
GI
TH
AIG
L
GGRDLS
R
E
V
GGIS
A
L
T
AL
E
ML
SA
D
E
K
S
EV
L
A
FV
SKPPA
E
AV
RL
KI
VNAM
KA
T
GKP
T
VA
L
FLG
YT
P
AVARDE
NV
W
FA
SSLD
EAA
RL
A
C
L
L
---
------------SRV
T
ARR
NA
IM
--
PASSGF
I
C
GL
Y
T
GGTL
A
A
EA
AG
LL
AGHL
G
VE
A
-
--
---
D
DAHH
H
GM
M
LD
A
DG
H
Q
I
I
D
L
GDD
FY
T
V
G
R
PHPMIDPTLRN
Q
LI
T
D
L
GA
K
P
Q
V
R
VLL
L
D
V
V
I
GFGA
TA
DPA
A
SLV
S
A
WQ
KA
C
A
-
A
RS
DN
Q
PL
YA
IA
T
V
T
GTE
R
DPQ
C
RSQQI
AT
L
E
DAG
IA
V
V
SS
LPE
A
T
LLAAALI
fig|502346.5.peg.623
Escherichia coli O157:H7 str. TW14588 (6-493/555)
IK
K
G
C
F
QDSVSLM
I
IS
R
K
L
S
ES
E
N
VD
DV
SV
M
MGTP
A
NK
AL
L
DTT
G
F
WHDDFN
NA
T
PND
I
C
V
AI
R
S
E
AADA
GI
A
Q
AI
-
M
QQL
EE
A
L
K
Q
LAQG
SG
--
S
S
Q
AL
T
QVRR
WD
SA
C
Q
KL
P
D
ANLALISV
A
G
E
YAA
E
L
A
N
QAL
DRN
LNVMMFSDNV
T
LEDE
IQ
LKT
R
AREKGLLVMGPDCGT
SM
I
A
G
T
PL
A
FANV
M
P
E
GNIGVIGASGTG
I
QEL
CS
Q
I
ALA
G
E
GI
TH
AIG
L
GGRDLS
R
E
V
GGIS
A
L
T
AL
E
ML
SA
D
E
K
S
EV
L
A
FV
SKPPA
E
AV
RL
KI
VNAM
KA
T
GKP
T
VA
L
FLG
YT
P
AVARDE
NV
W
FA
SSLD
EAA
RL
A
C
L
L
---
------------SRV
T
ARR
NA
IM
--
PASSGF
I
C
GL
Y
T
GGTL
A
A
EA
AG
LL
AGHL
G
VE
A
-
--
---
D
DAHH
H
GM
M
LD
A
DG
H
Q
I
I
D
L
GDD
FY
T
V
G
R
PHPMIDPTLRN
Q
LI
T
D
L
GA
K
P
Q
V
R
VLL
L
D
V
V
I
GFGA
TA
DPA
A
SLV
S
A
WQ
KA
C
A
-
A
RS
DN
Q
PL
YA
IA
T
V
T
GTE
R
DPQ
C
RSQQI
AT
L
E
DAG
IA
V
V
SS
LPE
A
T
LLAAALI
fig|701177.3.peg.639
Escherichia coli O55:H7 str. CB9615 (6-493/555)
IK
K
G
C
F
QDSVSLM
I
IS
R
K
L
S
ES
E
N
VD
DV
SV
M
MGTP
A
NK
AL
L
DTT
G
F
WHDDFN
NA
T
PND
I
C
V
AI
R
S
E
AADA
GI
A
Q
AI
-
M
QQL
EE
A
L
K
Q
LAQG
SG
--
S
S
Q
AL
T
QVRR
WD
SA
C
Q
KL
P
D
ANLALISV
A
G
E
YAA
E
L
A
N
QAL
DRN
LNVMMFSDNV
T
LEDE
IQ
LKT
R
AREKGLLVMGPDCGT
SM
I
A
G
T
PL
A
FANV
M
P
E
GNIGVIGASGTG
I
QEL
CS
Q
I
ALA
G
E
GI
TH
AIG
L
GGRDLS
R
E
V
GGIS
A
L
T
AL
E
ML
SA
D
E
K
S
EV
L
A
FV
SKPPA
E
AV
RL
KI
VNAM
KA
T
GKP
T
VA
L
FLG
YT
P
AVARDE
NV
W
FA
SSLD
EAA
RL
A
C
L
L
---
------------SRV
T
ARR
NA
IM
--
PASSGF
I
C
GL
Y
T
GGTL
A
A
EA
AG
LL
AGHL
G
VE
A
-
--
---
D
DAHH
H
GM
M
LD
A
DG
H
Q
I
I
D
L
GDD
FY
T
V
G
R
PHPMIDPTLRN
Q
LI
T
D
L
GA
K
P
Q
V
R
VLL
L
D
V
V
I
GFGA
TA
DPA
A
SLV
S
A
WQ
KA
C
A
-
A
RS
DN
Q
PL
YA
IA
T
V
T
GTE
R
DPQ
C
RSQQI
AT
L
E
DAG
IA
V
V
SS
LPE
A
T
LLAAALI
fig|550677.3.peg.964
Escherichia coli B354 (6-493/555)
IK
K
G
C
F
QDSVSLM
I
IS
R
K
L
S
ES
E
N
VD
DV
SV
M
MGTP
A
NK
AL
L
DTT
G
F
WHDDFN
NA
T
PND
I
C
V
AI
R
S
E
AADA
GI
A
Q
AI
-
M
QQL
EE
A
L
K
Q
LAQG
SG
--
S
S
Q
AL
T
QVRR
WD
SA
C
Q
KL
P
D
A
S
LALISV
A
G
E
YAA
E
L
A
N
QAL
DRN
LNVMMFSDNV
T
LEDE
IQ
LKT
R
AREKGLLVMGPDCGT
SM
I
A
G
T
PL
A
FANV
M
P
E
GNIGVIGASGTG
I
QEL
CS
Q
I
ALA
G
E
GI
TH
AIG
L
GGRDLS
R
E
V
GGIS
A
L
T
AL
E
ML
SA
D
E
K
S
EV
L
A
FV
SKPPA
E
AV
RL
KI
VNAM
KA
T
GKP
T
VA
L
FLG
YT
P
AVARDE
NV
W
FA
SSLD
EAA
RL
A
C
L
L
---
------------SRV
T
ARR
NA
IA
--
PVSSGF
I
C
GL
Y
T
GGTL
A
A
EA
AG
LL
AGHL
G
VE
A
-
--
---
D
DTHQ
H
GM
M
LD
A
DG
H
Q
I
LD
L
GDD
FY
T
V
G
R
PHPMIDPTLRN
Q
LI
A
D
L
GA
K
P
S
V
R
VLL
L
D
V
V
I
GFGA
TA
DPA
A
SLV
S
A
WQ
KA
C
A
-
A
RS
D
S
Q
PL
YA
IA
T
V
T
GTE
R
DPQ
C
RSQQI
AT
L
E
DAG
IA
V
V
SS
LPE
A
T
LLAAALI
fig|585057.4.peg.511
Escherichia coli IAI39 (6-493/555)
IK
K
G
C
F
QDSVSLM
I
IS
R
K
L
S
ES
E
N
VD
DV
SV
M
MGTP
A
NK
AL
L
DTT
G
F
WHDDFN
NA
T
PND
I
C
V
AI
R
S
E
AADA
GI
A
Q
AI
-
M
QQL
EE
A
L
K
Q
LAQG
SG
--
S
S
Q
AL
T
QVRR
WD
SA
C
Q
KL
P
D
ANLALISV
A
G
E
YAA
E
L
A
N
QAL
DRN
LNVMMFSDNV
T
LEDE
IQ
LKT
R
AREKGLLVMGPDCGT
SM
I
AA
T
PL
A
FANV
M
P
E
GNIGVIGASGTG
I
QEL
CS
Q
I
ALA
G
E
GI
TH
AIG
L
GGRDLS
R
E
V
GGIS
A
L
T
AL
E
ML
SA
D
E
K
S
EV
L
A
FV
SKPPA
E
AV
RL
KI
VNAM
KA
T
GKP
T
VA
L
FLG
YT
P
AVARDE
NV
W
FA
SSLD
EAA
RL
A
C
L
L
---
------------SRV
T
ARR
NA
IA
--
PVSSGF
I
C
GL
Y
T
GGTL
A
A
EA
AG
LL
AGHL
G
VE
A
-
--
---
D
DTHQ
H
GM
M
LD
A
DG
H
Q
I
LD
L
GDD
FY
T
V
G
R
PHPMIDPTLRN
L
LI
A
D
L
GA
K
P
Q
V
R
VLL
L
D
V
V
I
GFGA
TA
DPA
A
SLV
S
A
WQ
KA
C
A
-
A
RS
DN
Q
PL
YA
IA
T
V
T
GTE
R
DPQ
C
RSQQI
AT
L
E
DAG
IA
V
V
SS
LPE
A
T
LLAAALI
fig|585057.6.peg.510
Escherichia coli IAI39 (6-493/555)
IK
K
G
C
F
QDSVSLM
I
IS
R
K
L
S
ES
E
N
VD
DV
SV
M
MGTP
A
NK
AL
L
DTT
G
F
WHDDFN
NA
T
PND
I
C
V
AI
R
S
E
AADA
GI
A
Q
AI
-
M
QQL
EE
A
L
K
Q
LAQG
SG
--
S
S
Q
AL
T
QVRR
WD
SA
C
Q
KL
P
D
ANLALISV
A
G
E
YAA
E
L
A
N
QAL
DRN
LNVMMFSDNV
T
LEDE
IQ
LKT
R
AREKGLLVMGPDCGT
SM
I
AA
T
PL
A
FANV
M
P
E
GNIGVIGASGTG
I
QEL
CS
Q
I
ALA
G
E
GI
TH
AIG
L
GGRDLS
R
E
V
GGIS
A
L
T
AL
E
ML
SA
D
E
K
S
EV
L
A
FV
SKPPA
E
AV
RL
KI
VNAM
KA
T
GKP
T
VA
L
FLG
YT
P
AVARDE
NV
W
FA
SSLD
EAA
RL
A
C
L
L
---
------------SRV
T
ARR
NA
IA
--
PVSSGF
I
C
GL
Y
T
GGTL
A
A
EA
AG
LL
AGHL
G
VE
A
-
--
---
D
DTHQ
H
GM
M
LD
A
DG
H
Q
I
LD
L
GDD
FY
T
V
G
R
PHPMIDPTLRN
L
LI
A
D
L
GA
K
P
Q
V
R
VLL
L
D
V
V
I
GFGA
TA
DPA
A
SLV
S
A
WQ
KA
C
A
-
A
RS
DN
Q
PL
YA
IA
T
V
T
GTE
R
DPQ
C
RSQQI
AT
L
E
DAG
IA
V
V
SS
LPE
A
T
LLAAALI
fig|656417.3.peg.665
Escherichia coli M605 (6-493/555)
IK
K
G
C
F
QDSVSLM
I
IS
R
K
L
S
ES
E
N
VD
DV
SV
M
MGTP
A
NK
AL
L
DTT
G
F
WHDDFN
NA
T
PND
I
C
V
AI
R
S
E
AADA
GI
A
Q
AV
-
M
QQL
EE
A
L
K
Q
LAQG
SG
--
S
S
Q
AL
T
QVRR
WD
SA
S
Q
KL
P
D
ANLALISV
A
G
E
YAA
E
L
A
N
QAL
DRN
LNVMMFSDNV
T
LEDE
IQ
LKT
R
AREKGLLVMGPDCGT
SM
I
AA
T
PL
A
FANV
M
P
G
GNIGVIGASGTG
I
QEL
CS
Q
I
ALA
G
E
GI
TH
AIG
L
GGRDLS
R
E
V
GGIS
A
L
T
AL
E
ML
SA
D
E
K
S
EV
L
A
FV
SKPPA
E
AV
RL
KI
VNAM
KA
T
GKP
T
VA
L
FLG
YT
P
AVARDE
NV
W
FA
SSLD
EAA
RL
A
C
L
L
---
------------SRV
T
ARR
NA
IA
--
PVSSGF
I
C
GL
Y
T
GGTL
A
A
EA
AG
LL
AGHL
G
VE
A
-
--
---
D
DTHQ
H
GM
M
LD
A
DG
H
Q
I
LD
L
GDD
FY
T
V
G
R
PHPMIDPTLRN
L
LI
A
D
L
GA
K
P
Q
V
R
VLL
L
D
V
V
I
GFGA
TA
DPA
A
SLV
S
A
WQ
KA
C
A
-
A
RS
DN
Q
PL
YA
IA
T
V
T
GTE
R
DPQ
C
RSQQI
AT
L
E
DAG
IA
V
V
SS
LPE
A
T
LLAAALI
fig|550672.3.peg.51
Escherichia coli B088 (6-493/555)
IK
K
G
C
F
QDSVSLM
I
IS
R
K
L
S
ES
E
N
VD
DV
SV
M
MGTP
A
NK
AL
L
DTT
G
F
WHDDFN
NA
T
PND
I
C
V
AI
R
S
E
AADA
GI
A
Q
AI
-
M
QQL
EE
A
L
K
Q
LAQG
SG
--
S
S
Q
AL
T
QVRR
WD
SA
C
Q
KL
P
D
ANLALISV
A
G
E
YAA
E
L
A
N
QAL
DRN
LNVMMFSDNV
T
LEDE
IQ
LKT
R
AREKGLLVMGPDCGT
SM
I
A
G
T
PL
A
FANV
M
P
E
GNIGVIGASGTG
I
QEL
CS
Q
I
ALA
G
E
GI
TH
AIG
L
GGRDLS
R
E
V
GGIS
A
L
T
AL
E
ML
SA
D
E
K
S
EV
L
A
FV
SKPPA
E
AV
RL
KI
VNAM
KA
T
GKP
T
VA
L
FLG
YT
P
AVARDE
NV
W
FA
SSLD
EAA
RL
A
C
L
L
---
------------SRV
T
ARR
NA
IA
--
PVSSGF
I
C
GL
Y
T
GGTL
A
A
EA
AG
LL
AGHL
G
VE
A
-
--
---
D
DTHH
H
GM
M
LD
A
DG
H
Q
I
I
D
L
GDD
FY
T
V
G
R
PHPMIDP
A
LRN
Q
LI
A
D
L
GA
K
P
Q
V
R
VLL
L
D
V
V
I
GFGA
TA
DPA
A
SLV
S
A
WQ
KA
C
A
-
A
RS
DN
Q
PL
YA
IA
T
V
T
GTE
R
DPQ
C
RSQQI
AT
L
E
DAG
IA
V
V
SS
LPE
A
T
LLAAALI
fig|344610.3.peg.1523
Escherichia coli 53638 (6-493/555)
IK
K
G
C
F
QDSVSLM
I
IS
R
K
L
S
ES
E
N
VD
DV
SV
M
MGTP
A
NK
AL
L
DTT
G
F
WHDDFN
NA
T
PND
I
C
V
AI
R
S
E
AADA
GI
A
Q
AI
-
M
QQL
EE
A
L
K
Q
LAQG
SG
--
S
S
Q
AL
T
QVRR
WD
SA
C
Q
KL
P
D
A
S
LALISV
A
G
E
YAA
E
L
A
N
QAL
DRN
LNVMMFSDNV
T
LEDE
IQ
LKT
R
AREKGLLVMGPDCGT
SM
I
A
G
T
PL
A
FANV
M
P
E
GNIGVIGASGTG
I
QEL
CS
Q
I
AQA
G
E
GI
TH
AIG
L
GGRDLS
R
E
V
GGIS
A
L
T
AL
E
ML
SA
D
E
K
S
EV
L
A
FV
SKPPA
E
AV
RL
KI
VNAM
KA
T
GKP
T
VA
L
FLG
YT
P
AVARDE
NV
W
FA
SSLD
EAA
RL
A
C
L
L
---
------------SRV
T
ARR
NA
IA
--
PVSSGF
I
C
GL
Y
T
GGTL
A
A
EA
AG
LL
AGHL
G
VE
A
-
--
---
D
DTHH
H
GM
M
LD
A
DG
H
Q
I
I
D
L
GDD
FY
T
V
G
R
PHPMIDP
A
LRN
Q
LI
A
D
L
GA
K
P
Q
V
R
VLL
L
D
V
V
I
GFGA
TA
DPA
A
SLV
S
A
WQ
KA
C
A
-
A
RS
DN
Q
PL
YA
IA
T
V
T
GTE
R
DPQ
C
RSQQI
AT
L
E
DAG
IA
V
V
SS
LPE
A
T
LLAAALI
fig|344610.7.peg.1156
Escherichia coli 53638 (6-493/555)
IK
K
G
C
F
QDSVSLM
I
IS
R
K
L
S
ES
E
N
VD
DV
SV
M
MGTP
A
NK
AL
L
DTT
G
F
WHDDFN
NA
T
PND
I
C
V
AI
R
S
E
AADA
GI
A
Q
AI
-
M
QQL
EE
A
L
K
Q
LAQG
SG
--
S
S
Q
AL
T
QVRR
WD
SA
C
Q
KL
P
D
A
S
LALISV
A
G
E
YAA
E
L
A
N
QAL
DRN
LNVMMFSDNV
T
LEDE
IQ
LKT
R
AREKGLLVMGPDCGT
SM
I
A
G
T
PL
A
FANV
M
P
E
GNIGVIGASGTG
I
QEL
CS
Q
I
AQA
G
E
GI
TH
AIG
L
GGRDLS
R
E
V
GGIS
A
L
T
AL
E
ML
SA
D
E
K
S
EV
L
A
FV
SKPPA
E
AV
RL
KI
VNAM
KA
T
GKP
T
VA
L
FLG
YT
P
AVARDE
NV
W
FA
SSLD
EAA
RL
A
C
L
L
---
------------SRV
T
ARR
NA
IA
--
PVSSGF
I
C
GL
Y
T
GGTL
A
A
EA
AG
LL
AGHL
G
VE
A
-
--
---
D
DTHH
H
GM
M
LD
A
DG
H
Q
I
I
D
L
GDD
FY
T
V
G
R
PHPMIDP
A
LRN
Q
LI
A
D
L
GA
K
P
Q
V
R
VLL
L
D
V
V
I
GFGA
TA
DPA
A
SLV
S
A
WQ
KA
C
A
-
A
RS
DN
Q
PL
YA
IA
T
V
T
GTE
R
DPQ
C
RSQQI
AT
L
E
DAG
IA
V
V
SS
LPE
A
T
LLAAALI
fig|550676.3.peg.1327
Escherichia coli B185 (6-493/555)
IK
K
G
C
F
QDSVSLM
I
IS
R
K
L
S
ES
E
N
VD
DV
SV
M
MGTP
A
NK
AL
L
DTT
G
F
WHDDFN
NA
T
PND
I
C
V
AI
R
S
E
AADA
GI
A
Q
AI
-
M
QQL
EE
A
L
K
Q
LAQG
A
G
--
S
S
Q
AL
T
QVRR
WD
SA
C
Q
KL
P
D
ANLALISV
A
G
E
YAA
E
L
A
N
QAL
DRN
LNVMMFSDNV
T
LEDE
IQ
LKT
R
AREKGLLVMGPDCGT
SM
I
A
G
T
PL
A
FANV
M
P
E
GNIGVIGASGTG
I
QEL
CS
Q
I
ALA
G
E
GI
TH
AIG
L
GGRDLS
R
E
V
GGIS
A
L
T
AL
E
ML
SA
D
E
K
S
EV
L
A
FV
SKPPA
E
AV
RL
KI
VNAM
KA
T
GKP
T
VA
L
FLG
YT
P
AVARDE
NV
W
FA
SSLD
EAA
RL
A
C
L
L
---
------------SRV
T
ARR
NA
IT
--
PASSGF
I
C
GL
Y
T
GGTL
A
A
EA
AG
LL
AGNL
G
VE
A
-
--
---
D
DAHH
H
GM
M
LD
A
DG
H
Q
I
I
D
L
GDD
FY
T
V
G
R
PHPMIDPTLRN
Q
LI
A
D
L
GA
K
P
Q
V
R
VLL
L
D
V
V
I
GFGA
TA
DPA
A
SLV
S
A
WQ
KA
C
A
-
A
RS
DN
Q
PL
YA
IA
T
V
T
GTE
R
DPQ
C
RSQQI
AT
L
E
DAG
IA
V
V
SS
LPE
A
T
LLAAALI
fig|405955.13.peg.523
Escherichia coli APEC O1 (6-493/555)
IK
K
G
C
F
QDSVSLM
I
IS
R
K
L
S
ES
E
N
VD
DV
SV
M
MGTP
A
NK
AL
L
DTT
G
F
WHDDFN
H
A
T
PND
I
C
V
AI
R
S
E
AADA
GI
A
Q
AV
-
M
QQL
EE
A
L
K
Q
LAQG
SG
--
S
S
Q
AL
T
QVRR
WD
SA
S
Q
KL
P
D
ANLALISV
A
G
E
YAA
E
L
A
N
QAL
DRN
LNVMMFSDNV
T
LEDE
IQ
LKT
R
AREKGLLVMGPDCGT
SM
I
AA
T
PL
A
FANV
M
P
E
GNIGVIGASGTG
I
QEL
CS
Q
I
ALA
G
E
GI
TH
AIG
L
GGRDLS
R
E
V
GGIS
A
L
T
AL
E
ML
SA
D
E
K
S
EV
L
A
FV
SKPPA
E
T
V
RL
KI
VNAM
KA
T
GKP
T
VA
L
FLG
YT
P
AVARDE
NV
W
FA
SSLD
EAA
RL
A
C
L
L
---
------------SRV
T
ARR
NA
IA
--
PVSSGF
I
C
GL
Y
T
GGTL
A
A
EA
AG
LL
AGHL
G
VE
A
-
--
---
D
DTHQ
H
GM
M
LD
A
DG
H
Q
I
LD
L
GDD
FY
T
V
G
R
PHPMIDPTLRN
L
LI
A
D
L
GA
K
P
Q
V
R
VLL
L
D
V
V
I
GFGA
TA
DPA
A
SLV
S
A
WQ
KA
C
A
-
A
RS
DN
Q
PL
YA
IA
T
V
T
GTE
R
DPQ
C
RSQQI
AT
L
E
DAG
IA
V
V
SS
LPE
A
T
LLAAALI
fig|405955.9.peg.431
Escherichia coli APEC O1 (6-493/555)
IK
K
G
C
F
QDSVSLM
I
IS
R
K
L
S
ES
E
N
VD
DV
SV
M
MGTP
A
NK
AL
L
DTT
G
F
WHDDFN
H
A
T
PND
I
C
V
AI
R
S
E
AADA
GI
A
Q
AV
-
M
QQL
EE
A
L
K
Q
LAQG
SG
--
S
S
Q
AL
T
QVRR
WD
SA
S
Q
KL
P
D
ANLALISV
A
G
E
YAA
E
L
A
N
QAL
DRN
LNVMMFSDNV
T
LEDE
IQ
LKT
R
AREKGLLVMGPDCGT
SM
I
AA
T
PL
A
FANV
M
P
E
GNIGVIGASGTG
I
QEL
CS
Q
I
ALA
G
E
GI
TH
AIG
L
GGRDLS
R
E
V
GGIS
A
L
T
AL
E
ML
SA
D
E
K
S
EV
L
A
FV
SKPPA
E
T
V
RL
KI
VNAM
KA
T
GKP
T
VA
L
FLG
YT
P
AVARDE
NV
W
FA
SSLD
EAA
RL
A
C
L
L
---
------------SRV
T
ARR
NA
IA
--
PVSSGF
I
C
GL
Y
T
GGTL
A
A
EA
AG
LL
AGHL
G
VE
A
-
--
---
D
DTHQ
H
GM
M
LD
A
DG
H
Q
I
LD
L
GDD
FY
T
V
G
R
PHPMIDPTLRN
L
LI
A
D
L
GA
K
P
Q
V
R
VLL
L
D
V
V
I
GFGA
TA
DPA
A
SLV
S
A
WQ
KA
C
A
-
A
RS
DN
Q
PL
YA
IA
T
V
T
GTE
R
DPQ
C
RSQQI
AT
L
E
DAG
IA
V
V
SS
LPE
A
T
LLAAALI
fig|714962.3.peg.514
Escherichia coli IHE3034 (6-493/555)
IK
K
G
C
F
QDSVSLM
I
IS
R
K
L
S
ES
E
N
VD
DV
SV
M
MGTP
A
NK
AL
L
DTT
G
F
WHDDFN
H
A
T
PND
I
C
V
AI
R
S
E
AADA
GI
A
Q
AV
-
M
QQL
EE
A
L
K
Q
LAQG
SG
--
S
S
Q
AL
T
QVRR
WD
SA
S
Q
KL
P
D
ANLALISV
A
G
E
YAA
E
L
A
N
QAL
DRN
LNVMMFSDNV
T
LEDE
IQ
LKT
R
AREKGLLVMGPDCGT
SM
I
AA
T
PL
A
FANV
M
P
E
GNIGVIGASGTG
I
QEL
CS
Q
I
ALA
G
E
GI
TH
AIG
L
GGRDLS
R
E
V
GGIS
A
L
T
AL
E
ML
SA
D
E
K
S
EV
L
A
FV
SKPPA
E
T
V
RL
KI
VNAM
KA
T
GKP
T
VA
L
FLG
YT
P
AVARDE
NV
W
FA
SSLD
EAA
RL
A
C
L
L
---
------------SRV
T
ARR
NA
IA
--
PVSSGF
I
C
GL
Y
T
GGTL
A
A
EA
AG
LL
AGHL
G
VE
A
-
--
---
D
DTHQ
H
GM
M
LD
A
DG
H
Q
I
LD
L
GDD
FY
T
V
G
R
PHPMIDPTLRN
L
LI
A
D
L
GA
K
P
Q
V
R
VLL
L
D
V
V
I
GFGA
TA
DPA
A
SLV
S
A
WQ
KA
C
A
-
A
RS
DN
Q
PL
YA
IA
T
V
T
GTE
R
DPQ
C
RSQQI
AT
L
E
DAG
IA
V
V
SS
LPE
A
T
LLAAALI
fig|585035.6.peg.516
Escherichia coli S88 (6-493/555)
IK
K
G
C
F
QDSVSLM
I
IS
R
K
L
S
ES
E
N
VD
DV
SV
M
MGTP
A
NK
AL
L
DTT
G
F
WHDDFN
H
A
T
PND
I
C
V
AI
R
S
E
AADA
GI
A
Q
AV
-
M
QQL
EE
A
L
K
Q
LAQG
SG
--
S
S
Q
AL
T
QVRR
WD
SA
S
Q
KL
P
D
ANLALISV
A
G
E
YAA
E
L
A
N
QAL
DRN
LNVMMFSDNV
T
LEDE
IQ
LKT
R
AREKGLLVMGPDCGT
SM
I
AA
T
PL
A
FANV
M
P
E
GNIGVIGASGTG
I
QEL
CS
Q
I
ALA
G
E
GI
TH
AIG
L
GGRDLS
R
E
V
GGIS
A
L
T
AL
E
ML
SA
D
E
K
S
EV
L
A
FV
SKPPA
E
T
V
RL
KI
VNAM
KA
T
GKP
T
VA
L
FLG
YT
P
AVARDE
NV
W
FA
SSLD
EAA
RL
A
C
L
L
---
------------SRV
T
ARR
NA
IA
--
PVSSGF
I
C
GL
Y
T
GGTL
A
A
EA
AG
LL
AGHL
G
VE
A
-
--
---
D
DTHQ
H
GM
M
LD
A
DG
H
Q
I
LD
L
GDD
FY
T
V
G
R
PHPMIDPTLRN
L
LI
A
D
L
GA
K
P
Q
V
R
VLL
L
D
V
V
I
GFGA
TA
DPA
A
SLV
S
A
WQ
KA
C
A
-
A
RS
DN
Q
PL
YA
IA
T
V
T
GTE
R
DPQ
C
RSQQI
AT
L
E
DAG
IA
V
V
SS
LPE
A
T
LLAAALI
fig|869729.3.peg.3160
Escherichia coli UM146 (6-493/555)
IK
K
G
C
F
QDSVSLM
I
IS
R
K
L
S
ES
E
N
VD
DV
SV
M
MGTP
A
NK
AL
L
DTT
G
F
WHDDFN
H
A
T
PND
I
C
V
AI
R
S
E
AADA
GI
A
Q
AV
-
M
QQL
EE
A
L
K
Q
LAQG
SG
--
S
S
Q
AL
T
QVRR
WD
SA
S
Q
KL
P
D
ANLALISV
A
G
E
YAA
E
L
A
N
QAL
DRN
LNVMMFSDNV
T
LEDE
IQ
LKT
R
AREKGLLVMGPDCGT
SM
I
AA
T
PL
A
FANV
M
P
E
GNIGVIGASGTG
I
QEL
CS
Q
I
ALA
G
E
GI
TH
AIG
L
GGRDLS
R
E
V
GGIS
A
L
T
AL
E
ML
SA
D
E
K
S
EV
L
A
FV
SKPPA
E
T
V
RL
KI
VNAM
KA
T
GKP
T
VA
L
FLG
YT
P
AVARDE
NV
W
FA
SSLD
EAA
RL
A
C
L
L
---
------------SRV
T
ARR
NA
IA
--
PVSSGF
I
C
GL
Y
T
GGTL
A
A
EA
AG
LL
AGHL
G
VE
A
-
--
---
D
DTHQ
H
GM
M
LD
A
DG
H
Q
I
LD
L
GDD
FY
T
V
G
R
PHPMIDPTLRN
L
LI
A
D
L
GA
K
P
Q
V
R
VLL
L
D
V
V
I
GFGA
TA
DPA
A
SLV
S
A
WQ
KA
C
A
-
A
RS
DN
Q
PL
YA
IA
T
V
T
GTE
R
DPQ
C
RSQQI
AT
L
E
DAG
IA
V
V
SS
LPE
A
T
LLAAALI
fig|364106.7.peg.654
Escherichia coli UTI89 (6-493/555)
IK
K
G
C
F
QDSVSLM
I
IS
R
K
L
S
ES
E
N
VD
DV
SV
M
MGTP
A
NK
AL
L
DTT
G
F
WHDDFN
H
A
T
PND
I
C
V
AI
R
S
E
AADA
GI
A
Q
AV
-
M
QQL
EE
A
L
K
Q
LAQG
SG
--
S
S
Q
AL
T
QVRR
WD
SA
S
Q
KL
P
D
ANLALISV
A
G
E
YAA
E
L
A
N
QAL
DRN
LNVMMFSDNV
T
LEDE
IQ
LKT
R
AREKGLLVMGPDCGT
SM
I
AA
T
PL
A
FANV
M
P
E
GNIGVIGASGTG
I
QEL
CS
Q
I
ALA
G
E
GI
TH
AIG
L
GGRDLS
R
E
V
GGIS
A
L
T
AL
E
ML
SA
D
E
K
S
EV
L
A
FV
SKPPA
E
T
V
RL
KI
VNAM
KA
T
GKP
T
VA
L
FLG
YT
P
AVARDE
NV
W
FA
SSLD
EAA
RL
A
C
L
L
---
------------SRV
T
ARR
NA
IA
--
PVSSGF
I
C
GL
Y
T
GGTL
A
A
EA
AG
LL
AGHL
G
VE
A
-
--
---
D
DTHQ
H
GM
M
LD
A
DG
H
Q
I
LD
L
GDD
FY
T
V
G
R
PHPMIDPTLRN
L
LI
A
D
L
GA
K
P
Q
V
R
VLL
L
D
V
V
I
GFGA
TA
DPA
A
SLV
S
A
WQ
KA
C
A
-
A
RS
DN
Q
PL
YA
IA
T
V
T
GTE
R
DPQ
C
RSQQI
AT
L
E
DAG
IA
V
V
SS
LPE
A
T
LLAAALI
fig|364106.8.peg.652
Escherichia coli UTI89 (6-493/555)
IK
K
G
C
F
QDSVSLM
I
IS
R
K
L
S
ES
E
N
VD
DV
SV
M
MGTP
A
NK
AL
L
DTT
G
F
WHDDFN
H
A
T
PND
I
C
V
AI
R
S
E
AADA
GI
A
Q
AV
-
M
QQL
EE
A
L
K
Q
LAQG
SG
--
S
S
Q
AL
T
QVRR
WD
SA
S
Q
KL
P
D
ANLALISV
A
G
E
YAA
E
L
A
N
QAL
DRN
LNVMMFSDNV
T
LEDE
IQ
LKT
R
AREKGLLVMGPDCGT
SM
I
AA
T
PL
A
FANV
M
P
E
GNIGVIGASGTG
I
QEL
CS
Q
I
ALA
G
E
GI
TH
AIG
L
GGRDLS
R
E
V
GGIS
A
L
T
AL
E
ML
SA
D
E
K
S
EV
L
A
FV
SKPPA
E
T
V
RL
KI
VNAM
KA
T
GKP
T
VA
L
FLG
YT
P
AVARDE
NV
W
FA
SSLD
EAA
RL
A
C
L
L
---
------------SRV
T
ARR
NA
IA
--
PVSSGF
I
C
GL
Y
T
GGTL
A
A
EA
AG
LL
AGHL
G
VE
A
-
--
---
D
DTHQ
H
GM
M
LD
A
DG
H
Q
I
LD
L
GDD
FY
T
V
G
R
PHPMIDPTLRN
L
LI
A
D
L
GA
K
P
Q
V
R
VLL
L
D
V
V
I
GFGA
TA
DPA
A
SLV
S
A
WQ
KA
C
A
-
A
RS
DN
Q
PL
YA
IA
T
V
T
GTE
R
DPQ
C
RSQQI
AT
L
E
DAG
IA
V
V
SS
LPE
A
T
LLAAALI
fig|562.376.peg.630
Escherichia coli WV_060327 (6-493/555)
IK
K
G
C
F
QDSVSLM
I
IS
R
K
L
S
ES
E
N
VD
DV
SV
M
MGTP
A
NK
AL
L
DTT
G
F
WHDDFN
H
A
T
PND
I
C
V
AI
R
S
E
AADA
GI
A
Q
AV
-
M
QQL
EE
A
L
K
Q
LAQG
SG
--
S
S
Q
AL
T
QVRR
WD
SA
S
Q
KL
P
D
ANLALISV
A
G
E
YAA
E
L
A
N
QAL
DRN
LNVMMFSDNV
T
LEDE
IQ
LKT
R
AREKGLLVMGPDCGT
SM
I
AA
T
PL
A
FANV
M
P
E
GNIGVIGASGTG
I
QEL
CS
Q
I
ALA
G
E
GI
TH
AIG
L
GGRDLS
R
E
V
GGIS
A
L
T
AL
E
ML
SA
D
E
K
S
EV
L
A
FV
SKPPA
E
T
V
RL
KI
VNAM
KA
T
GKP
T
VA
L
FLG
YT
P
AVARDE
NV
W
FA
SSLD
EAA
RL
A
C
L
L
---
------------SRV
T
ARR
NA
IA
--
PVSSGF
I
C
GL
Y
T
GGTL
A
A
EA
AG
LL
AGHL
G
VE
A
-
--
---
D
DTHQ
H
GM
M
LD
A
DG
H
Q
I
LD
L
GDD
FY
T
V
G
R
PHPMIDPTLRN
L
LI
A
D
L
GA
K
P
Q
V
R
VLL
L
D
V
V
I
GFGA
TA
DPA
A
SLV
S
A
WQ
KA
C
A
-
A
RS
DN
Q
PL
YA
IA
T
V
T
GTE
R
DPQ
C
RSQQI
AT
L
E
DAG
IA
V
V
SS
LPE
A
T
LLAAALI
fig|749537.3.peg.2759
Escherichia coli MS 115-1 (6-493/555)
IK
K
G
C
F
QDSVSLM
I
IS
R
K
L
S
ES
E
N
VD
DV
SV
M
MGTP
A
NK
AL
L
DTT
G
F
WHDDFN
NA
T
PND
I
C
V
AI
R
S
E
AADA
GI
A
Q
AI
-
M
QQL
EE
A
L
K
Q
LAQG
SG
--
S
S
Q
AL
T
QVRR
WD
SA
C
Q
KL
P
D
A
S
LALISV
A
G
E
YAA
E
L
A
N
QAL
DRN
LNVMMFSDNV
T
LEDE
IQ
LKT
R
AREKGLLVMGPDCGT
SM
I
A
G
T
PL
A
FANV
M
P
E
GNIGVIGASGTG
I
QEL
CS
Q
I
AQA
G
E
GI
TH
AIG
L
GGRDLS
R
E
V
GGIS
A
L
T
AL
E
ML
SA
D
E
K
S
EV
L
A
FV
SKPPA
E
AV
RL
KI
VNAM
KA
T
GKP
T
VA
L
FLG
YT
P
AVARDE
NV
W
FA
SSLD
EAA
RL
A
C
L
L
---
------------SRV
T
ARR
NA
IA
--
PVSSGF
I
C
GL
Y
T
GGTL
A
A
EA
AG
LL
AGHL
G
VE
A
-
--
---
D
DTHH
H
GM
M
LD
A
DG
H
Q
I
I
D
L
GDD
FY
T
V
G
R
PHPMIDP
A
LRN
Q
LI
A
D
L
GA
K
P
Q
V
R
VLL
L
D
V
V
I
GFGA
TA
DPA
A
SLV
S
A
WQ
KA
C
A
-
A
RS
DN
Q
PL
YA
IA
T
V
T
GTE
R
DPQ
C
RSQQI
AK
L
E
DAG
IA
V
V
SS
LPE
A
T
LLAAALI
fig|216592.1.peg.277
Escherichia coli 042 (6-493/555)
IK
K
G
C
F
QDSVSLM
I
IS
R
K
L
S
ES
E
N
VD
DV
SV
M
MGTP
A
NK
AL
L
DTT
G
F
WHDDFN
NA
T
PND
I
C
V
AI
R
S
E
AADA
GI
A
Q
AI
-
M
QQL
EE
A
L
K
Q
LAQG
SG
--
S
S
Q
AL
T
QVRR
WD
SA
C
Q
KL
P
D
A
S
LALISV
A
G
E
YAA
E
L
A
N
QAL
DRN
LNVMMFSDNV
T
LEDE
IQ
LKT
R
AREKGLLVMGPDCGT
SM
I
A
G
T
PL
A
FANV
M
P
E
GNIGVIGASGTG
I
QEL
CS
Q
I
ALA
G
E
GI
TH
AIG
L
GGRDLS
R
E
V
GGIS
A
L
T
AL
E
ML
SA
D
E
K
S
EV
L
A
FV
SKPPA
E
AV
RL
KI
VNAM
KA
T
GKP
T
VA
L
FLG
YT
P
AVARDE
NV
W
FA
SSLD
EAA
RL
A
C
L
L
---
------------SRV
T
ARR
NA
IA
--
PVSSGF
I
C
GL
Y
T
GGTL
A
A
EA
AG
LL
AGHL
G
VE
A
-
--
---
D
DTHQ
H
GM
M
LD
A
DG
H
Q
I
LD
L
GDD
FY
T
V
G
R
PHPMIDPTLRN
L
LI
A
D
L
GA
K
P
Q
V
R
VLL
L
D
V
V
I
GFGA
TA
DPA
A
SLV
S
A
WQ
KA
C
A
-
A
RP
DN
Q
PL
YA
IA
T
V
T
GTE
R
DPQ
C
RSQQI
AT
L
E
DAG
IA
V
V
SS
LPE
A
T
LLAAALI
fig|216592.3.peg.588
Escherichia coli 042 (6-493/555)
IK
K
G
C
F
QDSVSLM
I
IS
R
K
L
S
ES
E
N
VD
DV
SV
M
MGTP
A
NK
AL
L
DTT
G
F
WHDDFN
NA
T
PND
I
C
V
AI
R
S
E
AADA
GI
A
Q
AI
-
M
QQL
EE
A
L
K
Q
LAQG
SG
--
S
S
Q
AL
T
QVRR
WD
SA
C
Q
KL
P
D
A
S
LALISV
A
G
E
YAA
E
L
A
N
QAL
DRN
LNVMMFSDNV
T
LEDE
IQ
LKT
R
AREKGLLVMGPDCGT
SM
I
A
G
T
PL
A
FANV
M
P
E
GNIGVIGASGTG
I
QEL
CS
Q
I
ALA
G
E
GI
TH
AIG
L
GGRDLS
R
E
V
GGIS
A
L
T
AL
E
ML
SA
D
E
K
S
EV
L
A
FV
SKPPA
E
AV
RL
KI
VNAM
KA
T
GKP
T
VA
L
FLG
YT
P
AVARDE
NV
W
FA
SSLD
EAA
RL
A
C
L
L
---
------------SRV
T
ARR
NA
IA
--
PVSSGF
I
C
GL
Y
T
GGTL
A
A
EA
AG
LL
AGHL
G
VE
A
-
--
---
D
DTHQ
H
GM
M
LD
A
DG
H
Q
I
LD
L
GDD
FY
T
V
G
R
PHPMIDPTLRN
L
LI
A
D
L
GA
K
P
Q
V
R
VLL
L
D
V
V
I
GFGA
TA
DPA
A
SLV
S
A
WQ
KA
C
A
-
A
RP
DN
Q
PL
YA
IA
T
V
T
GTE
R
DPQ
C
RSQQI
AT
L
E
DAG
IA
V
V
SS
LPE
A
T
LLAAALI
fig|753642.3.peg.1111
Escherichia coli NC101 (6-493/555)
IK
K
G
C
F
QDSVSLM
I
IS
R
K
L
S
ES
E
N
VD
DV
SV
M
MGTP
A
NK
AL
L
DTT
G
F
WHDDFN
NA
T
PND
I
C
V
AI
R
S
E
AADA
GI
A
Q
AV
-
M
QQL
EE
A
L
K
Q
LAQG
SG
--
S
S
Q
AL
T
QVRR
WD
SA
S
Q
KL
P
D
ANLALISV
A
G
E
YAA
E
L
A
N
QAL
DRN
LNVMMFSDNV
T
LEDE
IQ
LKT
R
AREKGLLVMGPDCGT
SM
I
AA
T
PL
A
FANV
M
P
E
GNIGVIGASGTG
I
QEL
CS
Q
I
ALA
G
E
GI
TH
AIG
L
GGRDLS
R
E
V
GGIS
A
L
T
AL
E
ML
SA
D
E
K
S
EV
L
A
FV
SKPPA
E
T
V
RL
KI
VNAM
KA
T
GKP
T
VA
L
FLG
YT
P
AVARDE
NV
W
FA
SSLD
EAA
RL
A
C
L
L
---
------------SRV
T
ARR
NA
IA
--
PVSSGF
I
C
GL
Y
T
GGTL
A
A
EA
AG
LL
AGHL
G
VE
A
-
--
---
D
DTHQ
H
GM
M
LD
A
DG
H
Q
I
LD
L
GDD
FY
T
V
G
R
PHPMIDPTLRN
L
LI
A
D
L
GA
K
P
Q
V
R
VLL
L
D
V
V
I
GFGA
TA
DPA
A
SLV
S
A
WQ
KA
C
A
-
A
RS
DN
Q
PL
YA
IA
T
V
T
GTE
R
DPQ
C
RSQQI
AT
L
E
DAG
IA
V
V
SS
LPE
A
T
LLAAALI
fig|431946.3.peg.496
Escherichia coli SE15 (6-493/555)
IK
K
G
C
F
QDSVSLM
I
IS
R
K
L
S
ES
E
N
VD
DV
SV
M
MGTP
A
NK
AL
L
DTT
G
F
WHDDFN
NA
T
PND
I
C
V
AI
R
S
E
AADA
GI
A
Q
AV
-
M
QQL
EE
A
L
K
Q
LAQG
SG
--
S
S
Q
AL
T
QVRR
WD
SA
S
Q
KL
P
D
ANLALISV
A
G
E
YAA
E
L
A
N
QAL
DRN
LNVMMFSDNV
T
LEDE
IQ
LKT
R
AREKGLLVMGPDCGT
SM
I
AA
T
PL
A
FANV
M
P
E
GNIGVIGASGTG
I
QEL
CS
Q
I
ALA
G
E
GI
TH
AIG
L
GGRDLS
R
E
V
GGIS
A
L
T
AL
E
ML
SV
D
E
K
S
EV
L
A
FV
SKPPA
E
AV
RL
KI
VNAM
KA
T
GKP
T
VA
L
FLG
YT
P
AVARDE
NV
W
FA
SSLD
EAA
RL
A
C
L
L
---
------------SRV
T
ARR
NA
IA
--
PVSSGF
I
C
GL
Y
T
GGTL
A
A
EA
AG
LL
AGHL
G
VE
A
-
--
---
D
DTHQ
H
GM
M
LD
A
DG
H
Q
I
LD
L
GDD
FY
T
V
G
R
PHPMIDPTLRN
L
LI
A
D
L
GA
K
P
Q
V
R
VLL
L
D
V
V
I
GFGA
TA
DPA
A
SLV
S
S
WQ
KA
C
A
-
A
RS
DN
Q
PL
YA
IA
T
V
T
GTE
R
DPQ
C
RSQQI
AT
L
E
DAG
IA
V
V
SS
LPE
A
T
LLAAALI
fig|656444.3.peg.1015
Escherichia coli TA280 (6-493/555)
IK
K
G
C
F
QDSVSLM
I
IS
R
K
L
S
ES
E
N
VD
DV
SV
M
MGTP
A
NK
AL
L
DTT
G
F
WHDDFN
NA
T
PND
I
C
V
AI
R
S
E
AADA
GI
A
Q
AI
-
M
QQL
EE
A
L
K
Q
LAQG
SG
--
S
S
Q
AL
T
QVRR
WD
SA
C
Q
KL
P
D
A
S
LALISV
A
G
E
YAA
E
L
A
N
QAL
DRN
LNVMMFSDNV
T
LEDE
IQ
LKT
R
AREKGLLVMGPDCGT
SM
I
A
G
T
PL
A
FANV
M
P
E
GNIGVIGASGTG
I
QEL
CS
Q
I
ALA
G
E
GI
TH
AIG
L
GGRDLS
R
E
V
GGIS
A
L
T
AL
E
ML
ST
D
A
K
S
EV
L
A
FV
SKPPA
E
AV
RL
KI
VNAM
KA
T
GKP
T
VA
L
FLG
YT
P
AVARDE
NV
W
FA
SSLD
EAA
RL
A
C
L
L
---
------------SRI
T
ARR
NA
IA
--
PVSSGF
I
C
GL
Y
T
GGTL
A
A
EA
AG
LL
ARHL
G
VV
A
-
--
---
D
GTHQ
H
GM
M
LD
A
DG
H
Q
I
LD
L
GDD
FY
T
V
G
R
PHPMIDPTLRN
L
LI
A
D
L
GA
K
P
Q
V
R
VLL
L
D
V
V
I
GFGA
TA
DPA
A
SLV
S
A
WQ
KA
C
A
-
A
RP
DN
Q
PL
YA
IA
T
V
T
GTE
R
DPQ
C
RSQQI
AT
L
E
DAG
IA
V
V
SS
LPE
A
T
LLAAALI
fig|656393.3.peg.1179
Escherichia coli H299 (6-493/555)
IK
K
G
C
F
QDSVSLM
I
IS
R
K
L
S
ES
E
N
VD
DV
SV
M
MGTP
A
NK
AL
L
DTT
G
F
WHDDFN
H
A
T
PND
I
C
V
AI
R
S
E
AADA
GI
A
Q
AV
-
M
QQL
EE
A
L
K
Q
LAQG
SG
--
S
S
Q
AL
T
QVRR
WD
SA
C
Q
KL
P
D
ANLALISV
A
G
E
YAA
E
L
A
N
QAL
DRN
LNVMMFSDNV
T
LEDE
IQ
LKT
R
AREKGLLVMGPDCGT
SM
I
AA
T
PL
A
FANV
M
P
E
GNIGVIGASGTG
I
QEL
CS
Q
I
ALA
G
E
GI
TH
AIG
L
GGRDLS
R
E
V
GGIS
A
L
T
AL
E
ML
SA
D
E
K
S
EV
L
A
FV
SKPPA
E
T
V
RL
KI
VNAM
KA
T
GKP
T
VA
L
FLG
YT
P
AVARDE
NV
W
FA
SSLD
EAA
RL
A
C
L
L
---
------------SRV
T
ARR
NA
IA
--
PVSSGF
I
C
GL
Y
T
GGTL
A
A
EA
AG
LL
AGHL
G
VE
A
-
--
---
D
DTHQ
H
GM
M
LD
A
DG
H
Q
I
LD
L
GDD
FY
T
V
G
R
PHPMIDPTLRN
L
LI
A
D
L
GA
K
P
Q
V
R
VLL
L
D
V
V
I
GFGA
TA
DPA
A
SLV
S
A
WQ
KA
C
A
-
A
RS
DN
Q
PL
YA
IA
T
V
T
GTE
R
DPQ
C
RSQQI
AT
L
E
DAG
IA
V
V
SS
LPE
A
T
LLAAALI
fig|656419.3.peg.749
Escherichia coli M718 (6-493/555)
IK
K
G
C
F
QDSVSLM
I
IS
R
K
L
S
ES
E
N
VD
DV
SV
M
MGTP
A
NK
AL
L
DTT
G
F
WHDDFN
NA
T
PND
I
C
V
AI
R
S
E
AADA
GI
A
Q
AI
-
M
QQL
EE
A
L
K
Q
LAQG
SG
--
S
S
Q
AL
T
QVRR
WD
SA
C
Q
KL
P
D
ANLALISV
A
G
E
YAA
E
L
A
N
QAL
DRN
LNVMMFSDNV
T
LEDE
IQ
LKT
R
AREKGLLVMGPDCGT
SM
I
AA
T
PL
A
FANV
M
P
E
GNIGVIGASGTG
I
QEL
CS
Q
I
ALA
G
E
GI
TH
AIG
L
GGRDLS
R
E
V
GGIS
A
L
T
AL
E
ML
SA
D
E
K
S
EV
L
A
FV
SKPPA
E
AV
RL
KI
VNAM
KA
T
GKP
T
VA
L
FLG
YT
P
AVARDE
NV
W
FA
SSLD
EAA
RL
A
C
L
L
---
------------SRV
T
ARR
NA
IT
--
PASSGF
I
C
GL
Y
T
GGTL
A
A
EA
AG
LL
AGHL
G
VE
A
-
--
---
D
DAHH
H
GM
M
LD
A
DG
H
Q
I
I
D
L
GDD
FY
T
V
G
R
PHPMIDPTLRN
Q
LI
A
D
L
GA
K
P
Q
V
R
VLL
L
D
V
V
I
GFGA
TA
DPA
A
SLV
S
A
WQ
KA
C
A
-
A
RS
DN
Q
PL
YA
IA
T
V
T
GTE
R
DPQ
C
RSQQI
AT
L
E
DAG
IA
V
V
SS
LPE
A
T
LLAAALI
fig|340186.3.peg.824
Escherichia coli E110019 (6-493/555)
IK
K
G
C
F
QDSVSLM
I
IS
R
K
L
S
ES
E
N
VD
DV
SV
M
MGTP
A
NK
AL
L
DTT
G
F
WHDDFN
NA
T
PND
I
C
V
AI
R
S
E
AADA
GI
A
Q
AI
-
M
QQL
EE
A
L
K
Q
LAQG
SG
--
S
S
Q
AL
T
QVRR
WD
SA
C
Q
KL
P
D
ANLALISV
A
G
E
YAA
E
L
T
N
QAL
DRN
LNVMMFSDNV
T
LEDE
IQ
LKT
R
AREKGLLVMGPDCGT
SM
I
A
G
T
PL
A
FANV
M
P
E
GNIGVIGASGTG
I
QEL
CS
Q
I
ALA
G
E
GI
TH
AIG
L
GGRDLS
R
E
V
GGIS
A
L
T
AL
E
ML
SA
D
E
K
S
EV
L
A
FV
SKPPA
E
AV
RL
KI
VNAM
KA
T
GKP
T
VA
L
FLG
YT
P
AVARDE
NV
W
FA
SSLD
EAA
RL
A
C
L
L
---
------------SRV
T
ARR
NA
IA
--
PVSSGF
I
C
GL
Y
T
GGTL
A
A
EA
AG
LL
AGHL
G
VE
A
-
--
---
D
DTHH
H
GM
M
LD
A
DG
H
Q
I
I
D
L
GDD
FY
T
V
G
R
PHPMIDP
A
LRN
Q
LI
A
D
L
GA
K
P
Q
V
R
VLL
L
D
V
V
I
GFGA
TA
DPA
A
SLV
S
A
WQ
KA
C
A
-
A
RS
D
S
Q
PL
YA
IA
T
V
T
GTE
R
DPQ
C
RSQQI
AT
L
E
DAG
IA
V
V
SS
LPE
A
T
LLAAALI
fig|340186.5.peg.859
Escherichia coli E110019 (6-493/555)
IK
K
G
C
F
QDSVSLM
I
IS
R
K
L
S
ES
E
N
VD
DV
SV
M
MGTP
A
NK
AL
L
DTT
G
F
WHDDFN
NA
T
PND
I
C
V
AI
R
S
E
AADA
GI
A
Q
AI
-
M
QQL
EE
A
L
K
Q
LAQG
SG
--
S
S
Q
AL
T
QVRR
WD
SA
C
Q
KL
P
D
ANLALISV
A
G
E
YAA
E
L
T
N
QAL
DRN
LNVMMFSDNV
T
LEDE
IQ
LKT
R
AREKGLLVMGPDCGT
SM
I
A
G
T
PL
A
FANV
M
P
E
GNIGVIGASGTG
I
QEL
CS
Q
I
ALA
G
E
GI
TH
AIG
L
GGRDLS
R
E
V
GGIS
A
L
T
AL
E
ML
SA
D
E
K
S
EV
L
A
FV
SKPPA
E
AV
RL
KI
VNAM
KA
T
GKP
T
VA
L
FLG
YT
P
AVARDE
NV
W
FA
SSLD
EAA
RL
A
C
L
L
---
------------SRV
T
ARR
NA
IA
--
PVSSGF
I
C
GL
Y
T
GGTL
A
A
EA
AG
LL
AGHL
G
VE
A
-
--
---
D
DTHH
H
GM
M
LD
A
DG
H
Q
I
I
D
L
GDD
FY
T
V
G
R
PHPMIDP
A
LRN
Q
LI
A
D
L
GA
K
P
Q
V
R
VLL
L
D
V
V
I
GFGA
TA
DPA
A
SLV
S
A
WQ
KA
C
A
-
A
RS
D
S
Q
PL
YA
IA
T
V
T
GTE
R
DPQ
C
RSQQI
AT
L
E
DAG
IA
V
V
SS
LPE
A
T
LLAAALI
fig|749545.3.peg.3658
Escherichia coli MS 182-1 (6-493/555)
IK
K
G
C
F
QDSVSLM
I
IS
R
K
L
S
ES
E
N
VD
DV
SV
M
MGTP
A
NK
AL
L
DTT
G
F
WHDDFN
NA
T
PND
I
C
V
AI
R
S
E
AADA
GI
A
Q
AI
-
M
QQL
EE
A
L
K
Q
LAQG
SG
--
S
S
Q
AL
T
QVRR
WD
SA
C
Q
KL
P
D
ANLALISV
A
G
E
YAA
E
L
T
N
QAL
DRN
LNVMMFSDNV
T
LEDE
IQ
LKT
R
AREKGLLVMGPDCGT
SM
I
A
G
T
PL
A
FANV
M
P
E
GNIGVIGASGTG
I
QEL
CS
Q
I
ALA
G
E
GI
TH
AIG
L
GGRDLS
R
E
V
GGIS
A
L
T
AL
E
ML
SA
D
E
K
S
EV
L
A
FV
SKPPA
E
AV
RL
KI
VNAM
KA
T
GKP
T
VA
L
FLG
YT
P
AVARDE
NV
W
FA
SSLD
EAA
RL
A
C
L
L
---
------------SRV
T
ARR
NA
IA
--
PVSSGF
I
C
GL
Y
T
GGTL
A
A
EA
AG
LL
AGHL
G
VE
A
-
--
---
D
DTHH
H
GM
M
LD
A
DG
H
Q
I
I
D
L
GDD
FY
T
V
G
R
PHPMIDP
A
LRN
Q
LI
A
D
L
GA
K
P
Q
V
R
VLL
L
D
V
V
I
GFGA
TA
DPA
A
SLV
S
A
WQ
KA
C
A
-
A
RS
D
S
Q
PL
YA
IA
T
V
T
GTE
R
DPQ
C
RSQQI
AT
L
E
DAG
IA
V
V
SS
LPE
A
T
LLAAALI
fig|749532.3.peg.2543
Escherichia coli MS 78-1 (6-493/555)
IK
K
G
C
F
QDSVSLM
I
IS
R
K
L
S
ES
E
N
VD
DV
SV
M
MGTP
A
NK
AL
L
DTT
G
F
WHDDFN
NA
T
PND
I
C
V
AI
R
S
E
AADA
GI
A
Q
AI
-
M
QQL
EE
A
L
K
Q
LAQG
SG
--
S
S
Q
AL
T
QVRR
WD
SA
C
Q
KL
P
D
ANLALISV
A
G
E
YAA
E
L
T
N
QAL
DRN
LNVMMFSDNV
T
LEDE
IQ
LKT
R
AREKGLLVMGPDCGT
SM
I
A
G
T
PL
A
FANV
M
P
E
GNIGVIGASGTG
I
QEL
CS
Q
I
ALA
G
E
GI
TH
AIG
L
GGRDLS
R
E
V
GGIS
A
L
T
AL
E
ML
SA
D
E
K
S
EV
L
A
FV
SKPPA
E
AV
RL
KI
VNAM
KA
T
GKP
T
VA
L
FLG
YT
P
AVARDE
NV
W
FA
SSLD
EAA
RL
A
C
L
L
---
------------SRV
T
ARR
NA
IA
--
PVSSGF
I
C
GL
Y
T
GGTL
A
A
EA
AG
LL
AGHL
G
VE
A
-
--
---
D
DTHH
H
GM
M
LD
A
DG
H
Q
I
I
D
L
GDD
FY
T
V
G
R
PHPMIDP
A
LRN
Q
LI
A
D
L
GA
K
P
Q
V
R
VLL
L
D
V
V
I
GFGA
TA
DPA
A
SLV
S
A
WQ
KA
C
A
-
A
RS
D
S
Q
PL
YA
IA
T
V
T
GTE
R
DPQ
C
RSQQI
AT
L
E
DAG
IA
V
V
SS
LPE
A
T
LLAAALI
fig|585396.4.peg.570
Escherichia coli O111:H- str. 11128 (6-493/555)
IK
K
G
C
F
QDSVSLM
I
IS
R
K
L
S
ES
E
N
VD
DV
SV
M
MGTP
A
NK
AL
L
DTT
G
F
WHDDFN
NA
T
PND
I
C
V
AI
R
S
E
AADA
GI
A
Q
AI
-
M
QQL
EE
A
L
K
Q
LAQG
SG
--
S
S
Q
AL
T
QVRR
WD
SA
C
Q
KL
P
D
ANLALISV
A
G
E
YAA
E
L
T
N
QAL
DRN
LNVMMFSDNV
T
LEDE
IQ
LKT
R
AREKGLLVMGPDCGT
SM
I
A
G
T
PL
A
FANV
M
P
E
GNIGVIGASGTG
I
QEL
CS
Q
I
ALA
G
E
GI
TH
AIG
L
GGRDLS
R
E
V
GGIS
A
L
T
AL
E
ML
SA
D
E
K
S
EV
L
A
FV
SKPPA
E
AV
RL
KI
VNAM
KA
T
GKP
T
VA
L
FLG
YT
P
AVARDE
NV
W
FA
SSLD
EAA
RL
A
C
L
L
---
------------SRV
T
ARR
NA
IA
--
PVSSGF
I
C
GL
Y
T
GGTL
A
A
EA
AG
LL
AGHL
G
VE
A
-
--
---
D
DTHH
H
GM
M
LD
A
DG
H
Q
I
I
D
L
GDD
FY
T
V
G
R
PHPMIDP
A
LRN
Q
LI
A
D
L
GA
K
P
Q
V
R
VLL
L
D
V
V
I
GFGA
TA
DPA
A
SLV
S
A
WQ
KA
C
A
-
A
RS
D
S
Q
PL
YA
IA
T
V
T
GTE
R
DPQ
C
RSQQI
AT
L
E
DAG
IA
V
V
SS
LPE
A
T
LLAAALI
fig|573235.3.peg.560
Escherichia coli O26:H11 str. 11368 (6-493/555)
IK
K
G
C
F
QDSVSLM
I
IS
R
K
L
S
ES
E
N
VD
DV
SV
M
MGTP
A
NK
AL
L
DTT
G
F
WHDDFN
NA
T
PND
I
C
V
AI
R
S
E
AADA
GI
A
Q
AI
-
M
QQL
EE
A
L
K
Q
LAQG
SG
--
S
S
Q
AL
T
QVRR
WD
SA
C
Q
KL
P
D
ANLALISV
A
G
E
YAA
E
L
T
N
QAL
DRN
LNVMMFSDNV
T
LEDE
IQ
LKT
R
AREKGLLVMGPDCGT
SM
I
A
G
T
PL
A
FANV
M
P
E
GNIGVIGASGTG
I
QEL
CS
Q
I
ALA
G
E
GI
TH
AIG
L
GGRDLS
R
E
V
GGIS
A
L
T
AL
E
ML
SA
D
E
K
S
EV
L
A
FV
SKPPA
E
AV
RL
KI
VNAM
KA
T
GKP
T
VA
L
FLG
YT
P
AVARDE
NV
W
FA
SSLD
EAA
RL
A
C
L
L
---
------------SRV
T
ARR
NA
IA
--
PVSSGF
I
C
GL
Y
T
GGTL
A
A
EA
AG
LL
AGHL
G
VE
A
-
--
---
D
DTHH
H
GM
M
LD
A
DG
H
Q
I
I
D
L
GDD
FY
T
V
G
R
PHPMIDP
A
LRN
Q
LI
A
D
L
GA
K
P
Q
V
R
VLL
L
D
V
V
I
GFGA
TA
DPA
A
SLV
S
A
WQ
KA
C
A
-
A
RS
D
S
Q
PL
YA
IA
T
V
T
GTE
R
DPQ
C
RSQQI
AT
L
E
DAG
IA
V
V
SS
LPE
A
T
LLAAALI
fig|585397.7.peg.538
Escherichia coli ED1a (6-493/555)
IK
K
G
C
F
QDSVSLM
I
IS
R
K
L
S
ES
E
N
VD
DV
SV
M
MGTP
A
NK
AL
L
DTT
G
F
WHDDFN
NA
T
PND
I
C
V
AI
R
S
E
AADA
GI
A
Q
AV
-
M
QQL
EE
A
L
K
Q
LAQG
SG
--
S
S
Q
AL
T
QVRR
WD
SA
C
Q
KL
P
D
ANLALISV
A
G
E
YAA
E
L
A
N
QAL
DRN
LNVMMFSDNV
T
LEDE
IQ
LKT
R
AREKGLLVMGPDCGT
SM
I
AA
T
PL
A
FANV
M
P
E
GNIGVIGASGTG
I
QEL
CS
Q
I
ALA
G
E
GI
TH
AIG
L
GGRDLS
R
E
V
GGIS
A
L
T
AL
E
ML
SA
D
E
K
S
EV
L
A
FV
SKPPA
E
T
V
RL
KI
VNAM
KA
T
GKP
T
VA
L
FLG
YT
P
AVARDE
NV
W
FA
SSLD
EAA
RL
A
C
L
L
---
------------SRV
T
ARR
NA
IA
--
PVSSGF
I
C
GL
Y
T
GGTL
A
A
EA
AG
LL
AGHL
G
VE
A
-
--
---
D
DTHQ
H
GM
M
LD
A
DG
H
Q
I
LD
L
GDD
FY
T
V
G
R
PHPMIDPTLRN
L
LI
A
D
L
GA
K
P
Q
V
R
VLL
L
D
V
V
I
GFGA
TA
DPA
A
SLV
S
A
WQ
KA
C
A
-
A
RS
DN
Q
PL
YA
IA
T
V
T
GTE
R
DPQ
C
RSQQI
AT
L
E
DAG
IA
V
V
SS
LPE
A
T
LLAAALI
fig|585397.9.peg.540
Escherichia coli ED1a (6-493/555)
IK
K
G
C
F
QDSVSLM
I
IS
R
K
L
S
ES
E
N
VD
DV
SV
M
MGTP
A
NK
AL
L
DTT
G
F
WHDDFN
NA
T
PND
I
C
V
AI
R
S
E
AADA
GI
A
Q
AV
-
M
QQL
EE
A
L
K
Q
LAQG
SG
--
S
S
Q
AL
T
QVRR
WD
SA
C
Q
KL
P
D
ANLALISV
A
G
E
YAA
E
L
A
N
QAL
DRN
LNVMMFSDNV
T
LEDE
IQ
LKT
R
AREKGLLVMGPDCGT
SM
I
AA
T
PL
A
FANV
M
P
E
GNIGVIGASGTG
I
QEL
CS
Q
I
ALA
G
E
GI
TH
AIG
L
GGRDLS
R
E
V
GGIS
A
L
T
AL
E
ML
SA
D
E
K
S
EV
L
A
FV
SKPPA
E
T
V
RL
KI
VNAM
KA
T
GKP
T
VA
L
FLG
YT
P
AVARDE
NV
W
FA
SSLD
EAA
RL
A
C
L
L
---
------------SRV
T
ARR
NA
IA
--
PVSSGF
I
C
GL
Y
T
GGTL
A
A
EA
AG
LL
AGHL
G
VE
A
-
--
---
D
DTHQ
H
GM
M
LD
A
DG
H
Q
I
LD
L
GDD
FY
T
V
G
R
PHPMIDPTLRN
L
LI
A
D
L
GA
K
P
Q
V
R
VLL
L
D
V
V
I
GFGA
TA
DPA
A
SLV
S
A
WQ
KA
C
A
-
A
RS
DN
Q
PL
YA
IA
T
V
T
GTE
R
DPQ
C
RSQQI
AT
L
E
DAG
IA
V
V
SS
LPE
A
T
LLAAALI
fig|685038.3.peg.491
Escherichia coli O83:H1 str. NRG 857C (6-493/555)
IK
K
G
C
F
QDSVSLM
I
IS
R
K
L
S
ES
E
N
VD
DV
SV
M
MGTP
A
NK
AL
L
DTT
G
F
WHDDFN
NA
T
PND
I
C
V
AI
R
S
E
AADA
GI
A
Q
AV
-
M
QQL
EE
A
L
K
Q
LAQG
SG
--
S
S
Q
AL
T
QVRR
WD
SA
C
Q
KL
P
D
ANLALISV
A
G
E
YAA
E
L
A
N
QAL
DRN
LNVMMFSDNV
T
LEDE
IQ
LKT
R
AREKGLLVMGPDCGT
SM
I
AA
T
PL
A
FANV
M
P
E
GNIGVIGASGTG
I
QEL
CS
Q
I
ALA
G
E
GI
TH
AIG
L
GGRDLS
R
E
V
GGIS
A
L
T
AL
E
ML
SA
D
E
K
S
EV
L
A
FV
SKPPA
E
T
V
RL
KI
VNAM
KA
T
GKP
T
VA
L
FLG
YT
P
AVARDE
NV
W
FA
SSLD
EAA
RL
A
C
L
L
---
------------SRV
T
ARR
NA
IA
--
PVSSGF
I
C
GL
Y
T
GGTL
A
A
EA
AG
LL
AGHL
G
VE
A
-
--
---
D
DTHQ
H
GM
M
LD
A
DG
H
Q
I
LD
L
GDD
FY
T
V
G
R
PHPMIDPTLRN
L
LI
A
D
L
GA
K
P
Q
V
R
VLL
L
D
V
V
I
GFGA
TA
DPA
A
SLV
S
A
WQ
KA
C
A
-
A
RS
DN
Q
PL
YA
IA
T
V
T
GTE
R
DPQ
C
RSQQI
AT
L
E
DAG
IA
V
V
SS
LPE
A
T
LLAAALI
fig|656440.3.peg.399
Escherichia coli TA206 (6-493/555)
IK
K
G
C
F
QDSVSLM
I
IS
R
K
L
S
ES
E
N
VD
DV
SV
M
MGTP
A
NK
AL
L
DTT
G
F
WHDDFN
NA
T
PND
I
C
V
AI
R
S
E
AADA
GI
A
Q
AV
-
M
QQL
EE
A
L
K
Q
LAQG
SG
--
S
S
Q
AL
T
QVRR
WD
SA
C
Q
KL
P
D
ANLALISV
A
G
E
YAA
E
L
A
N
QAL
DRN
LNVMMFSDNV
T
LEDE
IQ
LKT
R
AREKGLLVMGPDCGT
SM
I
AA
T
PL
A
FANV
M
P
E
GNIGVIGASGTG
I
QEL
CS
Q
I
ALA
G
E
GI
TH
AIG
L
GGRDLS
R
E
V
GGIS
A
L
T
AL
E
ML
SA
D
E
K
S
EV
L
A
FV
SKPPA
E
T
V
RL
KI
VNAM
KA
T
GKP
T
VA
L
FLG
YT
P
AVARDE
NV
W
FA
SSLD
EAA
RL
A
C
L
L
---
------------SRV
T
ARR
NA
IA
--
PVSSGF
I
C
GL
Y
T
GGTL
A
A
EA
AG
LL
AGHL
G
VE
A
-
--
---
D
DTHQ
H
GM
M
LD
A
DG
H
Q
I
LD
L
GDD
FY
T
V
G
R
PHPMIDPTLRN
L
LI
A
D
L
GA
K
P
Q
V
R
VLL
L
D
V
V
I
GFGA
TA
DPA
A
SLV
S
A
WQ
KA
C
A
-
A
RS
DN
Q
PL
YA
IA
T
V
T
GTE
R
DPQ
C
RSQQI
AT
L
E
DAG
IA
V
V
SS
LPE
A
T
LLAAALI
fig|362663.8.peg.580
Escherichia coli 536 (6-493/555)
IK
K
G
C
F
QDSVSLM
I
IS
R
K
L
S
ES
E
N
VD
DV
SV
M
MGTP
A
NK
AL
L
DTT
G
F
WHDDFN
NA
T
PND
I
C
V
AI
R
S
E
AADA
GI
A
Q
AV
-
M
QQL
EE
A
L
K
Q
LAQG
SG
--
S
S
Q
AL
T
QVRR
WD
SA
C
Q
KL
P
D
ANLALISV
A
G
E
YAA
E
L
A
N
QAL
DRN
LNVMMFSDNV
T
LEDE
IQ
LKT
R
AREKGLLVMGPDCGT
SM
I
AA
T
PL
A
FANV
M
P
E
GNIGVIGASGTG
I
QEL
CS
Q
I
ALA
G
E
GI
TH
AIG
L
GGRDLS
R
E
V
GGIS
A
L
T
AL
E
ML
SA
D
E
K
S
EV
L
A
FV
SKPPA
E
T
V
RL
KI
VNAM
KA
T
GKP
T
VA
L
FLG
YT
P
AVARDE
NV
W
FA
SSLD
EAA
RL
A
C
L
L
---
------------SRV
T
ARR
NA
IA
--
PVSSGF
I
C
GL
Y
T
GGTL
A
A
EA
AG
LL
AGHL
G
VE
A
-
--
---
D
DTHQ
H
GM
M
LD
A
DG
H
Q
I
LD
L
GDD
FY
T
V
G
R
PHPMIDPTLRN
L
LI
A
D
L
GA
K
P
Q
V
R
VLL
L
D
V
V
I
GFGA
TA
DPA
A
SLV
S
A
WQ
KA
C
A
-
A
RS
DN
Q
PL
YA
IA
T
V
T
GTE
R
DPQ
C
RSQQI
AT
L
E
DAG
IA
V
V
SS
LPE
A
T
LLAAALI
fig|362663.9.peg.581
Escherichia coli 536 (6-493/555)
IK
K
G
C
F
QDSVSLM
I
IS
R
K
L
S
ES
E
N
VD
DV
SV
M
MGTP
A
NK
AL
L
DTT
G
F
WHDDFN
NA
T
PND
I
C
V
AI
R
S
E
AADA
GI
A
Q
AV
-
M
QQL
EE
A
L
K
Q
LAQG
SG
--
S
S
Q
AL
T
QVRR
WD
SA
C
Q
KL
P
D
ANLALISV
A
G
E
YAA
E
L
A
N
QAL
DRN
LNVMMFSDNV
T
LEDE
IQ
LKT
R
AREKGLLVMGPDCGT
SM
I
AA
T
PL
A
FANV
M
P
E
GNIGVIGASGTG
I
QEL
CS
Q
I
ALA
G
E
GI
TH
AIG
L
GGRDLS
R
E
V
GGIS
A
L
T
AL
E
ML
SA
D
E
K
S
EV
L
A
FV
SKPPA
E
T
V
RL
KI
VNAM
KA
T
GKP
T
VA
L
FLG
YT
P
AVARDE
NV
W
FA
SSLD
EAA
RL
A
C
L
L
---
------------SRV
T
ARR
NA
IA
--
PVSSGF
I
C
GL
Y
T
GGTL
A
A
EA
AG
LL
AGHL
G
VE
A
-
--
---
D
DTHQ
H
GM
M
LD
A
DG
H
Q
I
LD
L
GDD
FY
T
V
G
R
PHPMIDPTLRN
L
LI
A
D
L
GA
K
P
Q
V
R
VLL
L
D
V
V
I
GFGA
TA
DPA
A
SLV
S
A
WQ
KA
C
A
-
A
RS
DN
Q
PL
YA
IA
T
V
T
GTE
R
DPQ
C
RSQQI
AT
L
E
DAG
IA
V
V
SS
LPE
A
T
LLAAALI
fig|525281.3.peg.2391
Escherichia coli 83972 (6-493/555)
IK
K
G
C
F
QDSVSLM
I
IS
R
K
L
S
ES
E
N
VD
DV
SV
M
MGTP
A
NK
AL
L
DTT
G
F
WHDDFN
NA
T
PND
I
C
V
AI
R
S
E
AADA
GI
A
Q
AV
-
M
QQL
EE
A
L
K
Q
LAQG
SG
--
S
S
Q
AL
T
QVRR
WD
SA
C
Q
KL
P
D
ANLALISV
A
G
E
YAA
E
L
A
N
QAL
DRN
LNVMMFSDNV
T
LEDE
IQ
LKT
R
AREKGLLVMGPDCGT
SM
I
AA
T
PL
A
FANV
M
P
E
GNIGVIGASGTG
I
QEL
CS
Q
I
ALA
G
E
GI
TH
AIG
L
GGRDLS
R
E
V
GGIS
A
L
T
AL
E
ML
SA
D
E
K
S
EV
L
A
FV
SKPPA
E
T
V
RL
KI
VNAM
KA
T
GKP
T
VA
L
FLG
YT
P
AVARDE
NV
W
FA
SSLD
EAA
RL
A
C
L
L
---
------------SRV
T
ARR
NA
IA
--
PVSSGF
I
C
GL
Y
T
GGTL
A
A
EA
AG
LL
AGHL
G
VE
A
-
--
---
D
DTHQ
H
GM
M
LD
A
DG
H
Q
I
LD
L
GDD
FY
T
V
G
R
PHPMIDPTLRN
L
LI
A
D
L
GA
K
P
Q
V
R
VLL
L
D
V
V
I
GFGA
TA
DPA
A
SLV
S
A
WQ
KA
C
A
-
A
RS
DN
Q
PL
YA
IA
T
V
T
GTE
R
DPQ
C
RSQQI
AT
L
E
DAG
IA
V
V
SS
LPE
A
T
LLAAALI
fig|655817.3.peg.638
Escherichia coli ABU 83972 (6-493/555)
IK
K
G
C
F
QDSVSLM
I
IS
R
K
L
S
ES
E
N
VD
DV
SV
M
MGTP
A
NK
AL
L
DTT
G
F
WHDDFN
NA
T
PND
I
C
V
AI
R
S
E
AADA
GI
A
Q
AV
-
M
QQL
EE
A
L
K
Q
LAQG
SG
--
S
S
Q
AL
T
QVRR
WD
SA
C
Q
KL
P
D
ANLALISV
A
G
E
YAA
E
L
A
N
QAL
DRN
LNVMMFSDNV
T
LEDE
IQ
LKT
R
AREKGLLVMGPDCGT
SM
I
AA
T
PL
A
FANV
M
P
E
GNIGVIGASGTG
I
QEL
CS
Q
I
ALA
G
E
GI
TH
AIG
L
GGRDLS
R
E
V
GGIS
A
L
T
AL
E
ML
SA
D
E
K
S
EV
L
A
FV
SKPPA
E
T
V
RL
KI
VNAM
KA
T
GKP
T
VA
L
FLG
YT
P
AVARDE
NV
W
FA
SSLD
EAA
RL
A
C
L
L
---
------------SRV
T
ARR
NA
IA
--
PVSSGF
I
C
GL
Y
T
GGTL
A
A
EA
AG
LL
AGHL
G
VE
A
-
--
---
D
DTHQ
H
GM
M
LD
A
DG
H
Q
I
LD
L
GDD
FY
T
V
G
R
PHPMIDPTLRN
L
LI
A
D
L
GA
K
P
Q
V
R
VLL
L
D
V
V
I
GFGA
TA
DPA
A
SLV
S
A
WQ
KA
C
A
-
A
RS
DN
Q
PL
YA
IA
T
V
T
GTE
R
DPQ
C
RSQQI
AT
L
E
DAG
IA
V
V
SS
LPE
A
T
LLAAALI
fig|340197.3.peg.2387
Escherichia coli F11 (6-493/555)
IK
K
G
C
F
QDSVSLM
I
IS
R
K
L
S
ES
E
N
VD
DV
SV
M
MGTP
A
NK
AL
L
DTT
G
F
WHDDFN
NA
T
PND
I
C
V
AI
R
S
E
AADA
GI
A
Q
AV
-
M
QQL
EE
A
L
K
Q
LAQG
SG
--
S
S
Q
AL
T
QVRR
WD
SA
C
Q
KL
P
D
ANLALISV
A
G
E
YAA
E
L
A
N
QAL
DRN
LNVMMFSDNV
T
LEDE
IQ
LKT
R
AREKGLLVMGPDCGT
SM
I
AA
T
PL
A
FANV
M
P
E
GNIGVIGASGTG
I
QEL
CS
Q
I
ALA
G
E
GI
TH
AIG
L
GGRDLS
R
E
V
GGIS
A
L
T
AL
E
ML
SA
D
E
K
S
EV
L
A
FV
SKPPA
E
T
V
RL
KI
VNAM
KA
T
GKP
T
VA
L
FLG
YT
P
AVARDE
NV
W
FA
SSLD
EAA
RL
A
C
L
L
---
------------SRV
T
ARR
NA
IA
--
PVSSGF
I
C
GL
Y
T
GGTL
A
A
EA
AG
LL
AGHL
G
VE
A
-
--
---
D
DTHQ
H
GM
M
LD
A
DG
H
Q
I
LD
L
GDD
FY
T
V
G
R
PHPMIDPTLRN
L
LI
A
D
L
GA
K
P
Q
V
R
VLL
L
D
V
V
I
GFGA
TA
DPA
A
SLV
S
A
WQ
KA
C
A
-
A
RS
DN
Q
PL
YA
IA
T
V
T
GTE
R
DPQ
C
RSQQI
AT
L
E
DAG
IA
V
V
SS
LPE
A
T
LLAAALI
fig|340197.5.peg.2502
Escherichia coli F11 (6-493/555)
IK
K
G
C
F
QDSVSLM
I
IS
R
K
L
S
ES
E
N
VD
DV
SV
M
MGTP
A
NK
AL
L
DTT
G
F
WHDDFN
NA
T
PND
I
C
V
AI
R
S
E
AADA
GI
A
Q
AV
-
M
QQL
EE
A
L
K
Q
LAQG
SG
--
S
S
Q
AL
T
QVRR
WD
SA
C
Q
KL
P
D
ANLALISV
A
G
E
YAA
E
L
A
N
QAL
DRN
LNVMMFSDNV
T
LEDE
IQ
LKT
R
AREKGLLVMGPDCGT
SM
I
AA
T
PL
A
FANV
M
P
E
GNIGVIGASGTG
I
QEL
CS
Q
I
ALA
G
E
GI
TH
AIG
L
GGRDLS
R
E
V
GGIS
A
L
T
AL
E
ML
SA
D
E
K
S
EV
L
A
FV
SKPPA
E
T
V
RL
KI
VNAM
KA
T
GKP
T
VA
L
FLG
YT
P
AVARDE
NV
W
FA
SSLD
EAA
RL
A
C
L
L
---
------------SRV
T
ARR
NA
IA
--
PVSSGF
I
C
GL
Y
T
GGTL
A
A
EA
AG
LL
AGHL
G
VE
A
-
--
---
D
DTHQ
H
GM
M
LD
A
DG
H
Q
I
LD
L
GDD
FY
T
V
G
R
PHPMIDPTLRN
L
LI
A
D
L
GA
K
P
Q
V
R
VLL
L
D
V
V
I
GFGA
TA
DPA
A
SLV
S
A
WQ
KA
C
A
-
A
RS
DN
Q
PL
YA
IA
T
V
T
GTE
R
DPQ
C
RSQQI
AT
L
E
DAG
IA
V
V
SS
LPE
A
T
LLAAALI
fig|749546.3.peg.3631
Escherichia coli MS 185-1 (6-493/555)
IK
K
G
C
F
QDSVSLM
I
IS
R
K
L
S
ES
E
N
VD
DV
SV
M
MGTP
A
NK
AL
L
DTT
G
F
WHDDFN
NA
T
PND
I
C
V
AI
R
S
E
AADA
GI
A
Q
AV
-
M
QQL
EE
A
L
K
Q
LAQG
SG
--
S
S
Q
AL
T
QVRR
WD
SA
C
Q
KL
P
D
ANLALISV
A
G
E
YAA
E
L
A
N
QAL
DRN
LNVMMFSDNV
T
LEDE
IQ
LKT
R
AREKGLLVMGPDCGT
SM
I
AA
T
PL
A
FANV
M
P
E
GNIGVIGASGTG
I
QEL
CS
Q
I
ALA
G
E
GI
TH
AIG
L
GGRDLS
R
E
V
GGIS
A
L
T
AL
E
ML
SA
D
E
K
S
EV
L
A
FV
SKPPA
E
T
V
RL
KI
VNAM
KA
T
GKP
T
VA
L
FLG
YT
P
AVARDE
NV
W
FA
SSLD
EAA
RL
A
C
L
L
---
------------SRV
T
ARR
NA
IA
--
PVSSGF
I
C
GL
Y
T
GGTL
A
A
EA
AG
LL
AGHL
G
VE
A
-
--
---
D
DTHQ
H
GM
M
LD
A
DG
H
Q
I
LD
L
GDD
FY
T
V
G
R
PHPMIDPTLRN
L
LI
A
D
L
GA
K
P
Q
V
R
VLL
L
D
V
V
I
GFGA
TA
DPA
A
SLV
S
A
WQ
KA
C
A
-
A
RS
DN
Q
PL
YA
IA
T
V
T
GTE
R
DPQ
C
RSQQI
AT
L
E
DAG
IA
V
V
SS
LPE
A
T
LLAAALI
fig|749550.3.peg.4656
Escherichia coli MS 200-1 (6-493/555)
IK
K
G
C
F
QDSVSLM
I
IS
R
K
L
S
ES
E
N
VD
DV
SV
M
MGTP
A
NK
AL
L
DTT
G
F
WHDDFN
NA
T
PND
I
C
V
AI
R
S
E
AADA
GI
A
Q
AV
-
M
QQL
EE
A
L
K
Q
LAQG
SG
--
S
S
Q
AL
T
QVRR
WD
SA
C
Q
KL
P
D
ANLALISV
A
G
E
YAA
E
L
A
N
QAL
DRN
LNVMMFSDNV
T
LEDE
IQ
LKT
R
AREKGLLVMGPDCGT
SM
I
AA
T
PL
A
FANV
M
P
E
GNIGVIGASGTG
I
QEL
CS
Q
I
ALA
G
E
GI
TH
AIG
L
GGRDLS
R
E
V
GGIS
A
L
T
AL
E
ML
SA
D
E
K
S
EV
L
A
FV
SKPPA
E
T
V
RL
KI
VNAM
KA
T
GKP
T
VA
L
FLG
YT
P
AVARDE
NV
W
FA
SSLD
EAA
RL
A
C
L
L
---
------------SRV
T
ARR
NA
IA
--
PVSSGF
I
C
GL
Y
T
GGTL
A
A
EA
AG
LL
AGHL
G
VE
A
-
--
---
D
DTHQ
H
GM
M
LD
A
DG
H
Q
I
LD
L
GDD
FY
T
V
G
R
PHPMIDPTLRN
L
LI
A
D
L
GA
K
P
Q
V
R
VLL
L
D
V
V
I
GFGA
TA
DPA
A
SLV
S
A
WQ
KA
C
A
-
A
RS
DN
Q
PL
YA
IA
T
V
T
GTE
R
DPQ
C
RSQQI
AT
L
E
DAG
IA
V
V
SS
LPE
A
T
LLAAALI
fig|749528.3.peg.3539
Escherichia coli MS 45-1 (6-493/555)
IK
K
G
C
F
QDSVSLM
I
IS
R
K
L
S
ES
E
N
VD
DV
SV
M
MGTP
A
NK
AL
L
DTT
G
F
WHDDFN
NA
T
PND
I
C
V
AI
R
S
E
AADA
GI
A
Q
AV
-
M
QQL
EE
A
L
K
Q
LAQG
SG
--
S
S
Q
AL
T
QVRR
WD
SA
C
Q
KL
P
D
ANLALISV
A
G
E
YAA
E
L
A
N
QAL
DRN
LNVMMFSDNV
T
LEDE
IQ
LKT
R
AREKGLLVMGPDCGT
SM
I
AA
T
PL
A
FANV
M
P
E
GNIGVIGASGTG
I
QEL
CS
Q
I
ALA
G
E
GI
TH
AIG
L
GGRDLS
R
E
V
GGIS
A
L
T
AL
E
ML
SA
D
E
K
S
EV
L
A
FV
SKPPA
E
T
V
RL
KI
VNAM
KA
T
GKP
T
VA
L
FLG
YT
P
AVARDE
NV
W
FA
SSLD
EAA
RL
A
C
L
L
---
------------SRV
T
ARR
NA
IA
--
PVSSGF
I
C
GL
Y
T
GGTL
A
A
EA
AG
LL
AGHL
G
VE
A
-
--
---
D
DTHQ
H
GM
M
LD
A
DG
H
Q
I
LD
L
GDD
FY
T
V
G
R
PHPMIDPTLRN
L
LI
A
D
L
GA
K
P
Q
V
R
VLL
L
D
V
V
I
GFGA
TA
DPA
A
SLV
S
A
WQ
KA
C
A
-
A
RS
DN
Q
PL
YA
IA
T
V
T
GTE
R
DPQ
C
RSQQI
AT
L
E
DAG
IA
V
V
SS
LPE
A
T
LLAAALI
fig|749527.3.peg.4975
Escherichia coli MS 21-1 (6-493/555)
IK
K
G
C
F
QDSVSLM
I
IS
R
K
L
S
ES
E
N
VD
DV
SV
M
MGTP
A
NK
AL
L
DTT
G
F
WHDDFN
NA
T
PND
I
C
V
AI
R
S
E
AADA
GI
A
Q
AV
-
M
QQL
EE
A
L
K
Q
LAQG
SG
--
S
S
Q
AL
T
QVRR
WD
SA
C
Q
KL
P
D
A
S
LALISV
A
G
E
YAA
E
L
A
N
QAL
DRN
LNVMMFSDNV
T
LEDE
IQ
LKT
R
AREKGLLVMGPDCGT
SM
I
AA
T
PL
A
FANV
M
P
E
GNIGVIGASGTG
I
QEL
CS
Q
I
ALA
G
E
GI
TH
AIG
L
GGRDLS
R
E
V
GGIS
A
L
T
AL
E
ML
SA
D
E
K
S
EV
L
A
FV
SKPPA
E
AV
RL
KI
VNAM
KA
T
GKP
T
VA
L
FLG
YT
P
AVARDE
NV
W
FA
SSLD
EAA
RL
A
C
L
L
---
------------SRV
T
ARR
NA
IA
--
PVSSGF
I
C
GL
Y
T
GGTL
A
A
EA
AG
LL
AGHL
G
VE
A
-
--
---
D
DTHQ
H
GM
M
LD
A
DG
H
Q
I
LD
L
GDD
FY
T
V
G
R
PHPMIDPTLRN
L
LI
A
D
L
GA
K
P
Q
V
R
VLL
L
D
V
V
I
GFGA
TA
DPA
A
SLV
S
A
WQ
KA
C
A
-
A
RS
DN
Q
PL
YA
IA
T
V
T
GTE
R
DPQ
C
RSQQI
AT
L
E
DAG
IA
V
V
SS
LPE
A
T
LLAAALI
fig|439855.10.peg.734
Escherichia coli SMS-3-5 (6-493/555)
IK
K
G
C
F
QDSVSLM
I
IS
R
K
L
S
ES
E
N
VD
DV
SV
M
MGTP
A
NK
AL
L
DTT
G
F
WHDDFN
H
A
T
PND
I
C
V
AI
R
S
E
AADA
GI
A
Q
AV
-
M
QQL
EE
A
L
K
Q
LAQG
SG
--
S
S
Q
AL
T
QVRR
WD
SA
C
Q
KL
P
D
A
S
LALISV
A
G
E
YAA
E
L
A
N
QAL
DRN
LNVMMFSDNV
T
LEDE
IQ
LKT
R
AREKGLLVMGPDCGT
SM
I
AA
T
PL
A
FANV
M
P
E
GNIGVIGASGTG
I
QEL
CS
Q
I
ALA
G
E
GI
TH
AIG
L
GGRDLS
R
E
V
GGIS
A
L
T
AL
E
ML
SA
D
E
K
S
EV
L
A
FV
SKPPA
E
AV
RL
KI
VNAM
KA
T
GKP
T
VA
L
FLG
YT
P
AVARDE
NV
W
FA
SSLD
EAA
RL
A
C
L
L
---
------------SRV
T
ARR
NA
IA
--
PVSSGF
I
C
GL
Y
T
GGTL
A
A
EA
AG
LL
AGHL
G
VE
A
-
--
---
D
DTHQ
H
GM
M
LD
A
DG
H
Q
I
LD
L
GDD
FY
T
V
G
R
PHPMIDPTLRN
L
LI
A
D
L
GA
K
P
Q
V
R
VLL
L
D
V
V
I
GFGA
TA
DPA
A
SLV
S
A
WQ
KA
C
A
-
A
RS
DN
Q
PL
YA
IA
T
V
T
GTE
R
DPQ
C
R
A
QQI
AT
L
E
DAG
IA
V
V
SS
LPE
A
T
LLAAALI
fig|199310.1.peg.609
Escherichia coli CFT073 (6-493/555)
IK
K
G
C
F
QDSVSLM
I
IS
R
K
L
S
ES
E
N
VD
DV
SV
M
MGTP
A
NK
AL
L
DTT
G
F
WHDDFN
NA
T
PND
I
C
V
AI
R
S
E
AADA
GI
A
Q
AV
-
M
QQL
EE
A
L
K
Q
LAQG
SG
--
S
S
Q
AL
T
QVRR
WD
SA
C
Q
KL
P
D
ANLALISV
A
G
E
YAA
E
L
A
N
QAL
DRN
LNVMMFSDNV
T
LEDE
IQ
LKT
R
AREKGLLVMGPDCGT
SM
I
AA
T
PL
A
FANV
M
P
E
GNIGVIGASGTG
I
QEL
CS
Q
I
ALA
G
E
GI
TH
AIG
L
GGRDLS
R
E
V
GGIS
A
L
T
AL
E
ML
SA
D
E
K
S
EV
L
A
FV
SKPPA
E
T
V
RL
KI
X
NAM
KA
T
GKP
T
VA
L
FLG
YT
P
AVARDE
NV
W
FA
SSLD
EAA
RL
A
C
L
L
---
------------SRV
T
ARR
NA
IA
--
PVSSGF
I
C
GL
Y
T
GGTL
A
A
EA
AG
LL
AGHL
G
VE
A
-
--
---
D
DTHQ
H
GM
M
LD
A
DG
H
Q
I
LD
L
GDD
FY
T
V
G
R
PHPMIDPTLRN
L
LI
A
D
L
GA
K
P
Q
V
R
VLL
L
D
V
V
I
GFGA
TA
DPA
A
SLV
S
A
WQ
KA
C
A
-
A
RS
DN
Q
PL
YA
IA
T
V
T
GTE
R
DPQ
C
RSQQI
AT
L
E
DAG
IA
V
V
SS
LPE
A
T
LLAAALI
fig|199310.4.peg.598
Escherichia coli CFT073 (6-493/555)
IK
K
G
C
F
QDSVSLM
I
IS
R
K
L
S
ES
E
N
VD
DV
SV
M
MGTP
A
NK
AL
L
DTT
G
F
WHDDFN
NA
T
PND
I
C
V
AI
R
S
E
AADA
GI
A
Q
AV
-
M
QQL
EE
A
L
K
Q
LAQG
SG
--
S
S
Q
AL
T
QVRR
WD
SA
C
Q
KL
P
D
ANLALISV
A
G
E
YAA
E
L
A
N
QAL
DRN
LNVMMFSDNV
T
LEDE
IQ
LKT
R
AREKGLLVMGPDCGT
SM
I
AA
T
PL
A
FANV
M
P
E
GNIGVIGASGTG
I
QEL
CS
Q
I
ALA
G
E
GI
TH
AIG
L
GGRDLS
R
E
V
GGIS
A
L
T
AL
E
ML
SA
D
E
K
S
EV
L
A
FV
SKPPA
E
T
V
RL
KI
X
NAM
KA
T
GKP
T
VA
L
FLG
YT
P
AVARDE
NV
W
FA
SSLD
EAA
RL
A
C
L
L
---
------------SRV
T
ARR
NA
IA
--
PVSSGF
I
C
GL
Y
T
GGTL
A
A
EA
AG
LL
AGHL
G
VE
A
-
--
---
D
DTHQ
H
GM
M
LD
A
DG
H
Q
I
LD
L
GDD
FY
T
V
G
R
PHPMIDPTLRN
L
LI
A
D
L
GA
K
P
Q
V
R
VLL
L
D
V
V
I
GFGA
TA
DPA
A
SLV
S
A
WQ
KA
C
A
-
A
RS
DN
Q
PL
YA
IA
T
V
T
GTE
R
DPQ
C
RSQQI
AT
L
E
DAG
IA
V
V
SS
LPE
A
T
LLAAALI
fig|478007.5.peg.933
Escherichia coli O157:H7 str. EC508 (6-493/555)
IK
K
G
C
F
QDSVSLM
I
IS
R
K
L
S
ES
E
N
VD
DV
SV
M
MGTP
A
NK
AL
L
DTT
G
F
WHDDFN
NA
T
PND
I
C
V
AI
R
S
E
AADA
GI
A
Q
AI
-
M
QQL
EE
A
L
K
Q
LAQG
SG
--
S
S
Q
AL
T
QVRR
WD
SA
C
Q
KL
P
D
ANLALISV
A
G
E
YAA
E
L
A
N
QAL
DRN
LNVMMFSDNV
T
LEDE
IQ
LKT
R
AREKGLLVMGPDCGT
SM
I
A
G
T
PL
A
FANV
M
P
E
GNIGVIGASGTG
I
QEL
CS
Q
I
ALA
G
E
GI
TH
AIG
L
GGRDLS
R
E
V
GGIS
A
L
T
AL
E
ML
SA
D
E
K
S
EV
L
A
FV
SKP
L
A
E
AV
RL
KI
VNAM
KA
T
GKP
T
VA
L
FLG
YT
P
AVARDE
NV
W
FA
SSLD
EAA
RL
A
C
L
L
---
------------SRV
T
ARR
NA
IM
--
PASSGF
I
C
GL
Y
T
GGTL
A
A
EA
AG
LL
AGHL
G
VE
A
-
--
---
D
DAHH
H
GM
M
LD
A
DG
H
Q
I
I
D
L
GDD
FY
T
V
G
R
PHPMIDPTLRN
Q
LI
T
D
L
GA
K
P
Q
V
R
VLL
L
D
V
V
I
GFGA
TA
DPA
A
SLV
S
A
WQ
KA
C
A
-
A
RS
DN
Q
PL
YA
IA
T
V
T
GTE
R
DPQ
C
RSQQI
AT
L
E
DAG
IA
V
V
SS
LPE
A
T
LLAAALI
fig|585055.6.peg.544
Escherichia coli 55989 (6-493/555)
IK
K
G
C
F
QDSVSLM
I
IS
R
K
L
S
ES
E
N
VD
DV
SV
M
MGTP
A
NK
AL
L
DTT
D
F
WHDDFN
NA
T
PND
I
C
V
AI
R
S
E
AADA
GI
A
Q
AI
-
M
QQL
EE
A
L
K
Q
LAQG
SG
--
S
S
Q
AL
T
QVRR
WD
SA
C
Q
KL
P
D
ANLALISV
A
G
E
YAA
E
L
A
N
QAL
DRN
LNVMMFSDNV
T
LEDE
IQ
LKT
R
AREKGLLVMGPDCGT
SM
I
A
G
T
PL
A
FANV
M
P
E
GNIGVIGASGTG
I
QEL
CS
Q
I
ALA
G
E
GI
TH
AIG
L
GGRDLS
R
E
V
GGIS
A
L
T
AL
E
ML
SA
D
E
K
S
EV
L
A
FV
SKPPA
E
AV
RL
KI
VNAM
KA
T
GKP
T
VA
L
FLG
YT
P
AVARDE
NV
W
FA
SSLD
EAA
RL
A
C
L
L
---
------------SRV
T
ARR
NA
IA
--
PVSSGF
I
C
GL
Y
T
GGTL
A
A
EA
AG
LL
AGHL
G
VE
A
-
--
---
D
DTHH
H
GM
M
LD
A
DG
H
Q
I
I
D
L
GDD
FY
T
V
G
R
PHPMIDP
A
LRN
Q
LI
A
D
L
GA
K
P
Q
V
R
VLL
L
D
V
V
I
GFGA
TA
DPA
A
SLV
S
A
WQ
KA
C
A
-
A
RS
DN
Q
PL
YA
IA
T
V
T
GTE
R
DPQ
C
RSQQI
AT
L
E
DAG
IA
V
V
SS
LPE
A
T
LLAAALI
fig|585055.8.peg.545
Escherichia coli 55989 (6-493/555)
IK
K
G
C
F
QDSVSLM
I
IS
R
K
L
S
ES
E
N
VD
DV
SV
M
MGTP
A
NK
AL
L
DTT
D
F
WHDDFN
NA
T
PND
I
C
V
AI
R
S
E
AADA
GI
A
Q
AI
-
M
QQL
EE
A
L
K
Q
LAQG
SG
--
S
S
Q
AL
T
QVRR
WD
SA
C
Q
KL
P
D
ANLALISV
A
G
E
YAA
E
L
A
N
QAL
DRN
LNVMMFSDNV
T
LEDE
IQ
LKT
R
AREKGLLVMGPDCGT
SM
I
A
G
T
PL
A
FANV
M
P
E
GNIGVIGASGTG
I
QEL
CS
Q
I
ALA
G
E
GI
TH
AIG
L
GGRDLS
R
E
V
GGIS
A
L
T
AL
E
ML
SA
D
E
K
S
EV
L
A
FV
SKPPA
E
AV
RL
KI
VNAM
KA
T
GKP
T
VA
L
FLG
YT
P
AVARDE
NV
W
FA
SSLD
EAA
RL
A
C
L
L
---
------------SRV
T
ARR
NA
IA
--
PVSSGF
I
C
GL
Y
T
GGTL
A
A
EA
AG
LL
AGHL
G
VE
A
-
--
---
D
DTHH
H
GM
M
LD
A
DG
H
Q
I
I
D
L
GDD
FY
T
V
G
R
PHPMIDP
A
LRN
Q
LI
A
D
L
GA
K
P
Q
V
R
VLL
L
D
V
V
I
GFGA
TA
DPA
A
SLV
S
A
WQ
KA
C
A
-
A
RS
DN
Q
PL
YA
IA
T
V
T
GTE
R
DPQ
C
RSQQI
AT
L
E
DAG
IA
V
V
SS
LPE
A
T
LLAAALI
fig|749540.3.peg.4809
Escherichia coli MS 146-1 (6-493/555)
IK
K
G
C
F
QDSVSLM
I
IS
R
K
L
S
ES
E
N
VD
DV
SV
M
MGTP
A
NK
AL
L
DTT
G
F
WHDDFN
NA
T
PND
I
C
V
AI
R
S
E
AADA
GI
A
Q
AI
-
M
QQL
EE
A
L
K
Q
LAQG
SG
--
S
S
Q
AL
T
QVRR
WD
SA
C
Q
KL
P
D
A
S
LALISV
A
G
E
YAA
E
L
A
N
QAL
DRN
LNVMMFSDNV
T
LEDE
IQ
LK
S
R
AREKGLLVMGPDCGT
SM
I
A
G
T
PL
A
FANV
M
P
E
GNIGVIGASGTG
I
QEL
CS
Q
I
ALA
G
E
GI
TH
AIG
L
GGRDLS
R
E
V
GGIS
A
L
T
AL
E
ML
SA
D
E
K
S
EV
L
A
FV
SKPPA
E
AV
RL
KI
VNAM
KA
T
GKP
T
VA
L
FLG
YT
P
AVARDE
NV
W
FA
SSLD
EAA
RL
A
C
L
L
---
------------SRV
T
ARR
NA
IT
--
PASSGF
I
C
GL
Y
T
GGTL
A
A
EA
AG
LL
AGHL
G
VE
A
-
--
---
D
DTHH
H
GM
M
LD
A
DG
H
Q
I
I
D
L
GDD
FY
T
V
G
R
PHPMIDP
A
LRN
Q
LI
A
D
L
GA
K
P
Q
V
R
VLL
L
D
V
V
I
GFGA
TA
DPA
A
SLV
S
A
WQ
KA
C
A
-
A
RS
DN
Q
PL
YA
IA
T
V
T
GTE
R
DPQ
C
RSQQI
AT
L
E
DAG
IA
V
V
SS
LPE
A
T
LLAAALI
fig|656414.3.peg.719
Escherichia coli H736 (6-493/555)
IK
K
G
C
F
QDSVSLM
I
IS
R
K
L
S
ES
E
N
VD
DV
SV
M
MGTP
A
NK
AL
L
DTT
G
F
WHDDFN
NA
T
PND
I
C
V
AI
R
S
E
AADA
GI
A
Q
AI
-
M
QQL
EE
A
L
K
Q
LAQG
SG
--
S
S
Q
AL
T
QVRR
WD
SA
C
Q
KL
P
D
A
S
LALISV
A
G
E
YAA
E
L
A
N
QAL
DRN
LNVMMFSDNV
T
LEDE
IQ
LK
S
R
AREKGLLVMGPDCGT
SM
I
A
G
T
PL
A
FANV
M
P
E
GNIGVIGASGTG
I
QEL
CS
Q
I
ALA
G
E
GI
TH
AIG
L
GGRDLS
R
E
V
GGIS
A
L
T
AL
E
ML
SA
D
E
K
S
EV
L
A
FV
SKPPA
E
AV
RL
KI
VNAM
KA
T
GKP
T
VA
L
FLG
YT
P
AVARDE
NV
W
FA
SSLD
EAA
RL
A
C
L
L
---
------------SRV
T
ARR
NA
IT
--
PASSGF
I
C
GL
Y
T
GGTL
A
A
EA
AG
LL
AGHL
G
VE
A
-
--
---
D
DTHH
H
GM
M
LD
A
DG
H
Q
I
I
D
L
GDD
FY
T
V
G
R
PHPMIDP
A
LRN
Q
LI
A
D
L
GA
K
P
Q
V
R
VLL
L
D
V
V
I
GFGA
TA
DPA
A
SLV
S
A
WQ
KA
C
A
-
A
RS
DN
Q
PL
YA
IA
T
V
T
GTE
R
DPQ
C
RSQQI
AT
L
E
DAG
IA
V
V
SS
LPE
A
T
LLAAALI
fig|331112.3.peg.552
Escherichia coli HS (6-493/555)
IK
K
G
C
F
QDSVSLM
I
IS
R
K
L
S
ES
E
N
VD
DV
SV
M
MGTP
A
NK
AL
L
DTT
G
F
WHDDFN
NA
T
PND
I
C
V
AI
R
S
E
AADA
GI
A
Q
AI
-
M
QQL
EE
A
L
K
Q
LAQG
A
G
--
S
S
Q
AL
T
QVRR
WD
SA
C
Q
KL
P
D
A
S
LALISV
A
G
E
YAA
E
L
A
N
QAL
DRN
LNVMMFSDNV
T
LEDE
IQ
LKT
R
AREKGLLVMGPDCGT
SM
I
A
G
T
PL
A
FANV
M
P
E
GNIGVIGASGTG
I
QEL
CS
Q
I
ALA
G
E
GI
TH
AIG
L
GGRDLS
R
E
V
GGIS
A
L
T
AL
E
ML
SA
D
E
K
S
EV
L
A
FV
SKPPA
E
AV
RL
KI
VNAM
KA
T
GKP
T
VA
L
FLG
YT
P
AVARDE
NV
W
FA
SSLD
EAA
RL
A
C
L
L
---
------------SRV
T
ARR
NA
IA
--
PVSSGF
I
C
GL
Y
T
GGTL
A
A
EA
AG
LL
AGHL
G
VE
A
-
--
---
D
DTHH
H
GM
M
LD
A
DG
H
Q
I
I
D
L
GDD
FY
T
V
G
R
PHPMIDP
A
LRN
Q
LI
A
D
L
GA
K
P
Q
V
R
VLL
L
D
V
V
I
GFGA
TA
DPA
A
SLV
S
A
WQ
KA
C
A
-
A
RS
DN
Q
PL
YA
IA
T
V
T
GTE
R
DPQ
C
RSQQI
AT
L
E
DAG
IA
V
V
SS
LPE
A
T
LLAAALI
fig|331112.6.peg.578
Escherichia coli HS (6-493/555)
IK
K
G
C
F
QDSVSLM
I
IS
R
K
L
S
ES
E
N
VD
DV
SV
M
MGTP
A
NK
AL
L
DTT
G
F
WHDDFN
NA
T
PND
I
C
V
AI
R
S
E
AADA
GI
A
Q
AI
-
M
QQL
EE
A
L
K
Q
LAQG
A
G
--
S
S
Q
AL
T
QVRR
WD
SA
C
Q
KL
P
D
A
S
LALISV
A
G
E
YAA
E
L
A
N
QAL
DRN
LNVMMFSDNV
T
LEDE
IQ
LKT
R
AREKGLLVMGPDCGT
SM
I
A
G
T
PL
A
FANV
M
P
E
GNIGVIGASGTG
I
QEL
CS
Q
I
ALA
G
E
GI
TH
AIG
L
GGRDLS
R
E
V
GGIS
A
L
T
AL
E
ML
SA
D
E
K
S
EV
L
A
FV
SKPPA
E
AV
RL
KI
VNAM
KA
T
GKP
T
VA
L
FLG
YT
P
AVARDE
NV
W
FA
SSLD
EAA
RL
A
C
L
L
---
------------SRV
T
ARR
NA
IA
--
PVSSGF
I
C
GL
Y
T
GGTL
A
A
EA
AG
LL
AGHL
G
VE
A
-
--
---
D
DTHH
H
GM
M
LD
A
DG
H
Q
I
I
D
L
GDD
FY
T
V
G
R
PHPMIDP
A
LRN
Q
LI
A
D
L
GA
K
P
Q
V
R
VLL
L
D
V
V
I
GFGA
TA
DPA
A
SLV
S
A
WQ
KA
C
A
-
A
RS
DN
Q
PL
YA
IA
T
V
T
GTE
R
DPQ
C
RSQQI
AT
L
E
DAG
IA
V
V
SS
LPE
A
T
LLAAALI
fig|679205.4.peg.227
Escherichia coli MS 124-1 (6-493/555)
IK
K
G
C
F
QDSVSLM
I
IS
R
K
L
S
ES
E
N
VD
DV
SV
M
MGTP
A
NK
AL
L
DTT
G
F
WHDDFN
NA
T
PND
I
C
V
AI
R
S
E
AADA
GI
A
Q
AI
-
M
QQL
EE
A
L
K
Q
LAQG
A
G
--
S
S
Q
AL
T
QVRR
WD
SA
C
Q
KL
P
D
A
S
LALISV
A
G
E
YAA
E
L
A
N
QAL
DRN
LNVMMFSDNV
T
LEDE
IQ
LKT
R
AREKGLLVMGPDCGT
SM
I
A
G
T
PL
A
FANV
M
P
E
GNIGVIGASGTG
I
QEL
CS
Q
I
ALA
G
E
GI
TH
AIG
L
GGRDLS
R
E
V
GGIS
A
L
T
AL
E
ML
SA
D
E
K
S
EV
L
A
FV
SKPPA
E
AV
RL
KI
VNAM
KA
T
GKP
T
VA
L
FLG
YT
P
AVARDE
NV
W
FA
SSLD
EAA
RL
A
C
L
L
---
------------SRV
T
ARR
NA
IA
--
PVSSGF
I
C
GL
Y
T
GGTL
A
A
EA
AG
LL
AGHL
G
VE
A
-
--
---
D
DTHH
H
GM
M
LD
A
DG
H
Q
I
I
D
L
GDD
FY
T
V
G
R
PHPMIDP
A
LRN
Q
LI
A
D
L
GA
K
P
Q
V
R
VLL
L
D
V
V
I
GFGA
TA
DPA
A
SLV
S
A
WQ
KA
C
A
-
A
RS
DN
Q
PL
YA
IA
T
V
T
GTE
R
DPQ
C
RSQQI
AT
L
E
DAG
IA
V
V
SS
LPE
A
T
LLAAALI
fig|749533.3.peg.1277
Escherichia coli MS 84-1 (6-493/555)
IK
K
G
C
F
QDSVSLM
I
IS
R
K
L
S
ES
E
N
VD
DV
SV
M
MGTP
A
NK
AL
L
DTT
G
F
WHDDFN
NA
T
PND
I
C
V
AI
R
S
E
AADA
GI
A
Q
AI
-
M
QQL
EE
A
L
K
Q
LAQG
A
G
--
S
S
Q
AL
T
QVRR
WD
SA
C
Q
KL
P
D
A
S
LALISV
A
G
E
YAA
E
L
A
N
QAL
DRN
LNVMMFSDNV
T
LEDE
IQ
LKT
R
AREKGLLVMGPDCGT
SM
I
A
G
T
PL
A
FANV
M
P
E
GNIGVIGASGTG
I
QEL
CS
Q
I
ALA
G
E
GI
TH
AIG
L
GGRDLS
R
E
V
GGIS
A
L
T
AL
E
ML
SA
D
E
K
S
EV
L
A
FV
SKPPA
E
AV
RL
KI
VNAM
KA
T
GKP
T
VA
L
FLG
YT
P
AVARDE
NV
W
FA
SSLD
EAA
RL
A
C
L
L
---
------------SRV
T
ARR
NA
IA
--
PVSSGF
I
C
GL
Y
T
GGTL
A
A
EA
AG
LL
AGHL
G
VE
A
-
--
---
D
DTHH
H
GM
M
LD
A
DG
H
Q
I
I
D
L
GDD
FY
T
V
G
R
PHPMIDP
A
LRN
Q
LI
A
D
L
GA
K
P
Q
V
R
VLL
L
D
V
V
I
GFGA
TA
DPA
A
SLV
S
A
WQ
KA
C
A
-
A
RS
DN
Q
PL
YA
IA
T
V
T
GTE
R
DPQ
C
RSQQI
AT
L
E
DAG
IA
V
V
SS
LPE
A
T
LLAAALI
fig|670888.3.peg.1100
Escherichia coli 1827-70 (6-493/555)
IK
K
G
C
F
QDSVSLM
I
IS
R
K
L
S
ES
E
N
VD
DV
SV
M
MGTP
A
NK
AL
L
DTT
G
F
WHDDFN
NA
T
PND
I
C
V
AI
R
S
E
AADA
GI
A
Q
AI
-
M
QQL
EE
A
L
K
Q
LAQG
A
G
--
S
S
Q
AL
T
QVRR
WD
SA
C
Q
KL
P
D
A
S
LALISV
A
G
E
YAA
E
L
A
N
QAL
DRN
LNVMMFSDNV
T
LEDE
IQ
LKT
R
AREKGLLVMGPDCGT
SM
I
A
G
T
L
L
A
FANV
M
P
E
GNIGVIGASGTG
I
QEL
CS
Q
I
ALA
G
E
GI
TH
AIG
L
GGRDLS
R
E
V
GGIS
A
L
T
AL
E
ML
SA
D
E
K
S
EV
L
A
FV
SKPPA
E
AV
RL
KI
VNAM
KA
T
GKP
T
VA
L
FLG
YT
P
AVARDE
NV
W
FA
SSLD
EAA
RL
A
C
L
L
---
------------SRV
T
ARR
NA
IA
--
PVSSGF
I
C
GL
Y
T
GGTL
A
A
EA
AG
LL
AGHL
G
VE
A
-
--
---
D
DTHH
H
GM
M
LD
A
DG
H
Q
I
I
D
L
GDD
FY
T
V
G
R
PHPMIDP
A
LRN
Q
LI
A
D
L
GA
K
P
Q
V
R
VLL
L
D
V
V
I
GFGA
TA
DPA
A
SLV
S
A
WQ
KA
C
A
-
A
RS
DN
Q
PL
YA
IA
T
V
T
GTE
R
DPQ
C
RSQQI
AT
L
E
DAG
IA
V
V
SS
LPE
A
T
LLAAALI
fig|656379.3.peg.1012
Escherichia coli FVEC1302 (6-493/555)
IK
K
G
C
F
QDSVSLM
I
IS
R
K
L
S
ES
E
N
VD
DV
SV
M
MGTP
A
NK
AL
L
DTT
G
F
WHDDFN
NA
T
PND
I
C
V
AI
R
S
E
AADA
GI
A
Q
AI
-
M
QQL
EE
A
L
K
Q
LAQG
SG
--
S
S
Q
AL
T
QVRR
WD
SA
C
Q
KL
P
D
A
S
LALISV
A
G
E
YAA
E
L
A
N
QAL
DRN
LNVMMFSDNV
T
LEDE
IQ
LKT
R
AR
D
KGLLVMGPDCGT
SM
I
AA
T
PL
A
FANV
M
P
E
GNIGVIGASGTG
I
QEL
CS
Q
I
ALA
G
E
GI
TH
AIG
L
GGRDLS
R
E
V
GGIS
A
L
T
AL
E
ML
SA
D
A
K
S
EV
L
A
FV
SKPPA
E
AV
RL
KI
VNAM
KA
T
GKP
T
VA
L
FLG
YT
P
AVARDE
NV
W
FA
SSLD
EAA
RL
A
C
L
L
---
------------SRV
T
ARR
NA
IA
--
PVSSGF
I
C
GL
Y
T
GGTL
A
A
EA
AG
LL
AGHL
G
VE
A
-
--
---
D
DTHQ
H
GM
M
LD
A
DG
H
Q
I
LD
L
GDD
FY
T
V
G
R
PHPMIDPTLRN
L
LI
A
D
L
GA
K
P
Q
V
R
VLL
L
D
V
V
I
GFGA
TA
DPA
A
SLV
S
A
WQ
KA
C
A
-
A
RP
DN
Q
PL
YA
IA
T
V
T
GTE
R
DPQ
C
RSQQI
AT
L
E
DAG
IA
V
V
SS
LPE
A
T
LLAAALI
fig|656380.3.peg.770
Escherichia coli FVEC1412 (6-493/555)
IK
K
G
C
F
QDSVSLM
I
IS
R
K
L
S
ES
E
N
VD
DV
SV
M
MGTP
A
NK
AL
L
DTT
G
F
WHDDFN
NA
T
PND
I
C
V
AI
R
S
E
AADA
GI
A
Q
AI
-
M
QQL
EE
A
L
K
Q
LAQG
SG
--
S
S
Q
AL
T
QVRR
WD
SA
C
Q
KL
P
D
A
S
LALISV
A
G
E
YAA
E
L
A
N
QAL
DRN
LNVMMFSDNV
T
LEDE
IQ
LKT
R
AR
D
KGLLVMGPDCGT
SM
I
AA
T
PL
A
FANV
M
P
E
GNIGVIGASGTG
I
QEL
CS
Q
I
ALA
G
E
GI
TH
AIG
L
GGRDLS
R
E
V
GGIS
A
L
T
AL
E
ML
SA
D
A
K
S
EV
L
A
FV
SKPPA
E
AV
RL
KI
VNAM
KA
T
GKP
T
VA
L
FLG
YT
P
AVARDE
NV
W
FA
SSLD
EAA
RL
A
C
L
L
---
------------SRV
T
ARR
NA
IA
--
PVSSGF
I
C
GL
Y
T
GGTL
A
A
EA
AG
LL
AGHL
G
VE
A
-
--
---
D
DTHQ
H
GM
M
LD
A
DG
H
Q
I
LD
L
GDD
FY
T
V
G
R
PHPMIDPTLRN
L
LI
A
D
L
GA
K
P
Q
V
R
VLL
L
D
V
V
I
GFGA
TA
DPA
A
SLV
S
A
WQ
KA
C
A
-
A
RP
DN
Q
PL
YA
IA
T
V
T
GTE
R
DPQ
C
RSQQI
AT
L
E
DAG
IA
V
V
SS
LPE
A
T
LLAAALI
fig|749549.3.peg.1423
Escherichia coli MS 198-1 (6-493/555)
IK
K
G
C
F
QDSVSLM
I
IS
R
K
L
S
ES
E
N
VD
DV
SV
M
MGTP
A
NK
AL
L
DTT
G
F
WHDDFN
NA
T
PND
I
C
V
AI
R
S
E
AADA
GI
A
Q
AI
-
M
QQL
EE
A
L
K
Q
LAQG
SG
--
S
S
Q
AL
T
QVRR
WD
SA
C
Q
KL
P
D
A
S
LALISV
A
G
E
YAA
E
L
A
N
QAL
DRN
LNVMMFSDNV
T
LEDE
IQ
LKT
R
AR
D
KGLLVMGPDCGT
SM
I
AA
T
PL
A
FANV
M
P
E
GNIGVIGASGTG
I
QEL
CS
Q
I
ALA
G
E
GI
TH
AIG
L
GGRDLS
R
E
V
GGIS
A
L
T
AL
E
ML
SA
D
A
K
S
EV
L
A
FV
SKPPA
E
AV
RL
KI
VNAM
KA
T
GKP
T
VA
L
FLG
YT
P
AVARDE
NV
W
FA
SSLD
EAA
RL
A
C
L
L
---
------------SRV
T
ARR
NA
IA
--
PVSSGF
I
C
GL
Y
T
GGTL
A
A
EA
AG
LL
AGHL
G
VE
A
-
--
---
D
DTHQ
H
GM
M
LD
A
DG
H
Q
I
LD
L
GDD
FY
T
V
G
R
PHPMIDPTLRN
L
LI
A
D
L
GA
K
P
Q
V
R
VLL
L
D
V
V
I
GFGA
TA
DPA
A
SLV
S
A
WQ
KA
C
A
-
A
RP
DN
Q
PL
YA
IA
T
V
T
GTE
R
DPQ
C
RSQQI
AT
L
E
DAG
IA
V
V
SS
LPE
A
T
LLAAALI
fig|585056.7.peg.766
Escherichia coli UMN026 (6-493/555)
IK
K
G
C
F
QDSVSLM
I
IS
R
K
L
S
ES
E
N
VD
DV
SV
M
MGTP
A
NK
AL
L
DTT
G
F
WHDDFN
NA
T
PND
I
C
V
AI
R
S
E
AADA
GI
A
Q
AI
-
M
QQL
EE
A
L
K
Q
LAQG
SG
--
S
S
Q
AL
T
QVRR
WD
SA
C
Q
KL
P
D
A
S
LALISV
A
G
E
YAA
E
L
A
N
QAL
DRN
LNVMMFSDNV
T
LEDE
IQ
LKT
R
AR
D
KGLLVMGPDCGT
SM
I
AA
T
PL
A
FANV
M
P
E
GNIGVIGASGTG
I
QEL
CS
Q
I
ALA
G
E
GI
TH
AIG
L
GGRDLS
R
E
V
GGIS
A
L
T
AL
E
ML
SA
D
A
K
S
EV
L
A
FV
SKPPA
E
AV
RL
KI
VNAM
KA
T
GKP
T
VA
L
FLG
YT
P
AVARDE
NV
W
FA
SSLD
EAA
RL
A
C
L
L
---
------------SRV
T
ARR
NA
IA
--
PVSSGF
I
C
GL
Y
T
GGTL
A
A
EA
AG
LL
AGHL
G
VE
A
-
--
---
D
DTHQ
H
GM
M
LD
A
DG
H
Q
I
LD
L
GDD
FY
T
V
G
R
PHPMIDPTLRN
L
LI
A
D
L
GA
K
P
Q
V
R
VLL
L
D
V
V
I
GFGA
TA
DPA
A
SLV
S
A
WQ
KA
C
A
-
A
RP
DN
Q
PL
YA
IA
T
V
T
GTE
R
DPQ
C
RSQQI
AT
L
E
DAG
IA
V
V
SS
LPE
A
T
LLAAALI
fig|1040638.4.peg.5223
Escherichia coli O104:H4 str. LB226692 (6-493/555)
IK
K
G
C
F
QDSVSLM
I
IS
R
K
L
S
ES
E
N
VD
DV
SV
M
MGTP
A
NK
AL
L
DTT
D
F
WHDDFN
NA
T
PND
I
C
V
AI
R
S
E
AADA
GI
A
Q
AI
-
M
QQL
EE
A
L
K
Q
LAQG
SG
--
S
S
L
AL
T
QVRR
WD
SA
C
Q
KL
P
D
ANLALISV
A
G
E
YAA
E
L
A
N
QAL
DRN
LNVMMFSDNV
T
LEDE
IQ
LKT
R
AREKGLLVMGPDCGT
SM
I
A
G
T
PL
A
FANV
M
P
E
GNIGVIGASGTG
I
QEL
CS
Q
I
ALA
G
E
GI
TH
AIG
L
GGRDLS
R
E
V
GGIS
A
L
T
AL
E
ML
SA
D
E
K
S
EV
L
A
FV
SKPPA
E
AV
RL
KI
VNAM
KA
T
GKP
T
VA
L
FLG
YT
P
AVARDE
NV
W
FA
SSLD
EAA
RL
A
C
L
L
---
------------SRV
T
ARR
NA
IA
--
PVSSGF
I
C
GL
Y
T
GGTL
A
A
EA
AG
LL
AGHL
G
VE
A
-
--
---
D
DTHH
H
GM
M
LD
A
DG
H
Q
I
I
D
L
GDD
FY
T
V
G
R
PHPMIDP
A
LRN
Q
LI
A
D
L
GA
K
P
Q
V
R
VLL
L
D
V
V
I
GFGA
TA
DPA
A
SLV
S
A
WQ
KA
C
A
-
A
RS
DN
Q
PL
YA
IA
T
V
T
GTE
R
DPQ
C
RSQQI
AT
L
E
DAG
IA
V
V
SS
LPE
A
T
LLAAALI
fig|6666666.5357.peg.1694
Escherichia coli TY-2482 (6-493/555)
IK
K
G
C
F
QDSVSLM
I
IS
R
K
L
S
ES
E
N
VD
DV
SV
M
MGTP
A
NK
AL
L
DTT
D
F
WHDDFN
NA
T
PND
I
C
V
AI
R
S
E
AADA
GI
A
Q
AI
-
M
QQL
EE
A
L
K
Q
LAQG
SG
--
S
S
L
AL
T
QVRR
WD
SA
C
Q
KL
P
D
ANLALISV
A
G
E
YAA
E
L
A
N
QAL
DRN
LNVMMFSDNV
T
LEDE
IQ
LKT
R
AREKGLLVMGPDCGT
SM
I
A
G
T
PL
A
FANV
M
P
E
GNIGVIGASGTG
I
QEL
CS
Q
I
ALA
G
E
GI
TH
AIG
L
GGRDLS
R
E
V
GGIS
A
L
T
AL
E
ML
SA
D
E
K
S
EV
L
A
FV
SKPPA
E
AV
RL
KI
VNAM
KA
T
GKP
T
VA
L
FLG
YT
P
AVARDE
NV
W
FA
SSLD
EAA
RL
A
C
L
L
---
------------SRV
T
ARR
NA
IA
--
PVSSGF
I
C
GL
Y
T
GGTL
A
A
EA
AG
LL
AGHL
G
VE
A
-
--
---
D
DTHH
H
GM
M
LD
A
DG
H
Q
I
I
D
L
GDD
FY
T
V
G
R
PHPMIDP
A
LRN
Q
LI
A
D
L
GA
K
P
Q
V
R
VLL
L
D
V
V
I
GFGA
TA
DPA
A
SLV
S
A
WQ
KA
C
A
-
A
RS
DN
Q
PL
YA
IA
T
V
T
GTE
R
DPQ
C
RSQQI
AT
L
E
DAG
IA
V
V
SS
LPE
A
T
LLAAALI
fig|670897.3.peg.199
Escherichia coli 2362-75 (6-493/555)
IK
K
G
C
F
QDSVSLM
I
IS
R
K
L
S
ES
E
N
VD
DV
SV
M
MGTP
A
NK
AL
L
DTT
G
F
WHDDFN
NA
T
PND
I
C
V
AI
R
S
E
AADA
GI
A
Q
AV
-
M
QQL
EE
A
L
K
Q
LAQG
SG
--
S
S
Q
AL
T
QVRR
WD
SA
S
Q
KL
P
D
ANLALISV
A
G
E
YAA
E
L
A
N
QAL
DRN
LNVMMFSDNV
T
LEDE
IQ
LKT
R
AREKGLLVMGPDCGT
SM
I
AA
T
PL
A
FANV
M
P
E
GNIGVIGASGTG
I
QEL
CS
Q
I
ALA
G
E
GI
TH
AIG
L
GGRDLS
R
E
V
GGIS
A
L
T
AL
E
ML
SA
D
E
K
S
EV
L
A
FV
SKPPA
E
T
V
RL
KI
VNAM
KA
T
GK
T
T
VA
L
FLG
YT
P
AVARDE
NV
W
FA
SSLD
EAA
RL
A
C
L
L
---
------------SRV
T
ARR
NA
IA
--
PASSGF
I
C
GL
Y
T
GGTL
A
A
EA
AG
LL
AGHL
G
VE
A
-
--
---
D
DTHQ
H
GM
M
LD
A
DG
H
Q
I
LD
L
GDD
FY
T
V
G
R
PHPMIDPTLRN
L
LI
A
D
L
GA
K
P
Q
V
R
VLL
L
D
V
V
I
GFGA
TA
DPA
A
SLV
S
A
WQ
KA
C
A
-
A
RS
DN
Q
PL
YA
IA
T
V
T
GTE
R
DPQ
C
R
A
QQI
AT
L
E
DAG
IA
V
V
SS
LPE
A
T
LLAAALI
fig|216593.1.peg.3072
Escherichia coli E2348/69 (6-493/555)
IK
K
G
C
F
QDSVSLM
I
IS
R
K
L
S
ES
E
N
VD
DV
SV
M
MGTP
A
NK
AL
L
DTT
G
F
WHDDFN
NA
T
PND
I
C
V
AI
R
S
E
AADA
GI
A
Q
AV
-
M
QQL
EE
A
L
K
Q
LAQG
SG
--
S
S
Q
AL
T
QVRR
WD
SA
S
Q
KL
P
D
ANLALISV
A
G
E
YAA
E
L
A
N
QAL
DRN
LNVMMFSDNV
T
LEDE
IQ
LKT
R
AREKGLLVMGPDCGT
SM
I
AA
T
PL
A
FANV
M
P
E
GNIGVIGASGTG
I
QEL
CS
Q
I
ALA
G
E
GI
TH
AIG
L
GGRDLS
R
E
V
GGIS
A
L
T
AL
E
ML
SA
D
E
K
S
EV
L
A
FV
SKPPA
E
T
V
RL
KI
VNAM
KA
T
GK
T
T
VA
L
FLG
YT
P
AVARDE
NV
W
FA
SSLD
EAA
RL
A
C
L
L
---
------------SRV
T
ARR
NA
IA
--
PASSGF
I
C
GL
Y
T
GGTL
A
A
EA
AG
LL
AGHL
G
VE
A
-
--
---
D
DTHQ
H
GM
M
LD
A
DG
H
Q
I
LD
L
GDD
FY
T
V
G
R
PHPMIDPTLRN
L
LI
A
D
L
GA
K
P
Q
V
R
VLL
L
D
V
V
I
GFGA
TA
DPA
A
SLV
S
A
WQ
KA
C
A
-
A
RS
DN
Q
PL
YA
IA
T
V
T
GTE
R
DPQ
C
R
A
QQI
AT
L
E
DAG
IA
V
V
SS
LPE
A
T
LLAAALI
fig|574521.7.peg.483
Escherichia coli O127:H6 str. E2348/69 (6-493/555)
IK
K
G
C
F
QDSVSLM
I
IS
R
K
L
S
ES
E
N
VD
DV
SV
M
MGTP
A
NK
AL
L
DTT
G
F
WHDDFN
NA
T
PND
I
C
V
AI
R
S
E
AADA
GI
A
Q
AV
-
M
QQL
EE
A
L
K
Q
LAQG
SG
--
S
S
Q
AL
T
QVRR
WD
SA
S
Q
KL
P
D
ANLALISV
A
G
E
YAA
E
L
A
N
QAL
DRN
LNVMMFSDNV
T
LEDE
IQ
LKT
R
AREKGLLVMGPDCGT
SM
I
AA
T
PL
A
FANV
M
P
E
GNIGVIGASGTG
I
QEL
CS
Q
I
ALA
G
E
GI
TH
AIG
L
GGRDLS
R
E
V
GGIS
A
L
T
AL
E
ML
SA
D
E
K
S
EV
L
A
FV
SKPPA
E
T
V
RL
KI
VNAM
KA
T
GK
T
T
VA
L
FLG
YT
P
AVARDE
NV
W
FA
SSLD
EAA
RL
A
C
L
L
---
------------SRV
T
ARR
NA
IA
--
PASSGF
I
C
GL
Y
T
GGTL
A
A
EA
AG
LL
AGHL
G
VE
A
-
--
---
D
DTHQ
H
GM
M
LD
A
DG
H
Q
I
LD
L
GDD
FY
T
V
G
R
PHPMIDPTLRN
L
LI
A
D
L
GA
K
P
Q
V
R
VLL
L
D
V
V
I
GFGA
TA
DPA
A
SLV
S
A
WQ
KA
C
A
-
A
RS
DN
Q
PL
YA
IA
T
V
T
GTE
R
DPQ
C
R
A
QQI
AT
L
E
DAG
IA
V
V
SS
LPE
A
T
LLAAALI
fig|749531.3.peg.1529
Escherichia coli MS 69-1 (6-493/555)
IK
K
G
C
F
QDSVSLM
I
IS
R
K
L
S
ES
E
N
VD
DV
SV
M
MGTP
A
NK
AL
L
ETT
G
F
WHDDFN
NA
T
PND
I
C
V
AI
R
S
E
AADA
GI
A
Q
AI
-
M
QQL
EE
A
L
K
Q
LAQG
SG
--
S
S
Q
AL
T
QVRR
WD
SA
C
Q
KL
P
D
A
S
LALISV
A
G
E
YAA
E
L
A
N
QAL
DRN
LNVMMFSDNV
T
LEDE
IQ
LKT
R
AR
D
KGLLVMGPDCGT
SM
I
AA
T
PL
A
FANV
M
P
E
GNIGVIGASGTG
I
QEL
CS
Q
I
ALA
E
E
GI
TH
AIG
L
GGRDLS
R
E
V
GGIS
A
L
T
AL
E
ML
SA
D
A
K
S
EV
L
A
FV
SKPPA
E
AV
RL
KI
VNAM
KA
T
GKP
T
VA
L
FLG
YT
P
AVARDE
NV
W
FA
SSLD
EAA
RL
A
C
L
L
---
------------SRV
T
ARR
NA
IA
--
PVSSGF
I
C
GL
Y
T
GGTL
A
A
EA
AG
LL
AGHL
G
VE
A
-
--
---
D
DTHQ
H
GM
M
LD
A
DG
H
Q
I
LD
L
GDD
FY
T
V
G
R
PHPMIDPTLRN
L
LI
A
D
L
GA
K
P
Q
V
R
VLL
L
D
V
V
I
GFGA
TA
DPA
A
SLV
S
A
WQ
KA
C
A
-
A
RP
DN
Q
PL
YA
IA
T
V
T
GTE
R
DPQ
C
RSQQI
AT
L
E
DAG
IA
V
V
SS
LPE
A
T
LLAAALI
fig|562.375.peg.3965
Escherichia coli EC4100B (6-493/555)
IK
K
G
C
F
QDSVSLM
I
IS
R
K
L
S
ES
E
N
VD
DV
SV
M
MGTP
A
NK
AL
L
DTT
G
F
WHDDFN
NA
T
PND
I
C
V
AI
R
S
E
AADA
GI
A
Q
AI
-
M
QQL
EE
A
L
K
Q
LAQG
SG
--
S
S
Q
SL
T
QVRR
WD
SA
C
Q
KL
P
D
A
S
LALISV
A
G
E
YAA
E
L
A
N
QAL
DRN
LNVMMFSDNV
T
LEDE
IQ
LKT
R
AREKGLLVMGPDCGT
SM
I
AA
T
PL
A
FANV
M
P
E
GNIGVIGASGTG
I
QEL
CS
Q
I
ALA
G
E
GI
TH
AIG
L
GGRDLS
R
E
V
GGIS
A
L
T
AL
E
ML
SA
D
E
K
S
EV
L
A
FV
SKPPA
E
AV
RL
KI
VNAM
KA
T
GKP
T
VA
L
FLG
YT
P
AVARDE
NV
W
FA
SSLD
EAA
RL
A
C
L
L
---
------------SRV
T
ARR
NA
IT
--
PASSGF
I
C
GL
Y
T
GGTL
A
A
EA
AG
LL
AGHL
G
VE
A
-
--
---
D
DTHH
H
GM
M
LD
A
DG
H
Q
I
I
D
L
GDD
FY
T
V
G
R
PHPMIDP
A
LRN
Q
LI
A
D
L
GA
K
P
Q
V
R
VLL
L
D
V
V
I
GFGA
TA
DPA
A
SLV
S
A
WQ
KA
C
A
-
A
RS
D
S
Q
PL
YA
IA
T
V
T
GTE
R
DPQ
C
RSQQI
AT
L
E
DAG
IA
V
V
SS
LPE
A
T
LLAAALI
fig|595495.4.peg.4207
Escherichia coli KO11 (6-493/555)
IK
K
G
C
F
QDSVSLM
I
IS
R
K
L
S
ES
E
N
VD
DV
SV
M
MGTP
A
NK
AL
L
DTT
G
F
WHDDFN
NA
T
PND
I
C
V
AI
R
S
E
AADA
GI
A
Q
AI
-
M
QQL
EE
A
L
K
Q
LAQG
SG
--
S
S
Q
SL
T
QVRR
WD
SA
C
Q
KL
S
D
ANLALISV
A
G
E
YAA
E
L
A
N
QAL
DRN
LNVMMFSDNV
T
LEDE
IQ
LKT
R
AREKGLLVMGPDCGT
SM
I
AA
T
PL
A
FANV
M
P
E
GNIGVIGASGTG
I
QEL
CS
Q
I
ALA
G
E
GI
TH
AIG
L
GGRDLS
R
E
V
GGIS
A
L
T
AL
E
ML
SA
D
E
K
S
EV
L
A
FV
SKPPA
E
AV
RL
KI
VNAM
KA
T
GKP
T
VA
L
FLG
YT
P
AVARDE
NV
W
FA
SSLD
EAA
RL
A
C
L
L
---
------------SRV
T
ARR
NA
IA
--
PVSSGF
I
C
GL
Y
T
GGTL
A
A
EA
AG
LL
AGHL
G
VE
A
-
--
---
D
DTHH
H
GM
M
LD
A
DG
H
Q
I
I
D
L
GDD
FY
T
V
G
R
PHPMIDP
A
LRN
Q
LI
A
D
L
GA
K
P
Q
V
R
VLL
L
D
V
V
I
GFGA
TA
DPA
A
SLV
S
A
WQ
KA
C
A
-
A
RS
D
S
Q
PL
YA
IA
T
V
T
GTE
R
DPQ
C
RSQQI
AT
L
E
DAG
IA
V
V
SS
LPE
A
T
LLAAALI
fig|409438.11.peg.671
Escherichia coli SE11 (6-493/555)
IK
K
G
C
F
QDSVSLM
I
IS
R
K
L
S
ES
E
N
VD
DV
SV
M
MGTP
A
NK
AL
L
DTT
G
F
WHDDFN
NA
T
PND
I
C
V
AI
R
S
E
AADA
GI
A
Q
AI
-
M
QQL
EE
A
L
K
Q
LAQG
SG
--
S
S
Q
SL
T
QVRR
WD
SA
C
Q
KL
S
D
ANLALISV
A
G
E
YAA
E
L
A
N
QAL
DRN
LNVMMFSDNV
T
LEDE
IQ
LKT
R
AREKGLLVMGPDCGT
SM
I
AA
T
PL
A
FANV
M
P
E
GNIGVIGASGTG
I
QEL
CS
Q
I
ALA
G
E
GI
TH
AIG
L
GGRDLS
R
E
V
GGIS
A
L
T
AL
E
ML
SA
D
E
K
S
EV
L
A
FV
SKPPA
E
AV
RL
KI
VNAM
KA
T
GKP
T
VA
L
FLG
YT
P
AVARDE
NV
W
FA
SSLD
EAA
RL
A
C
L
L
---
------------SRV
T
ARR
NA
IA
--
PVSSGF
I
C
GL
Y
T
GGTL
A
A
EA
AG
LL
AGHL
G
VE
A
-
--
---
D
DTHH
H
GM
M
LD
A
DG
H
Q
I
I
D
L
GDD
FY
T
V
G
R
PHPMIDP
A
LRN
Q
LI
A
D
L
GA
K
P
Q
V
R
VLL
L
D
V
V
I
GFGA
TA
DPA
A
SLV
S
A
WQ
KA
C
A
-
A
RS
D
S
Q
PL
YA
IA
T
V
T
GTE
R
DPQ
C
RSQQI
AT
L
E
DAG
IA
V
V
SS
LPE
A
T
LLAAALI
fig|566546.3.peg.4386
Escherichia coli W (6-493/555)
IK
K
G
C
F
QDSVSLM
I
IS
R
K
L
S
ES
E
N
VD
DV
SV
M
MGTP
A
NK
AL
L
DTT
G
F
WHDDFN
NA
T
PND
I
C
V
AI
R
S
E
AADA
GI
A
Q
AI
-
M
QQL
EE
A
L
K
Q
LAQG
SG
--
S
S
Q
SL
T
QVRR
WD
SA
C
Q
KL
S
D
ANLALISV
A
G
E
YAA
E
L
A
N
QAL
DRN
LNVMMFSDNV
T
LEDE
IQ
LKT
R
AREKGLLVMGPDCGT
SM
I
AA
T
PL
A
FANV
M
P
E
GNIGVIGASGTG
I
QEL
CS
Q
I
ALA
G
E
GI
TH
AIG
L
GGRDLS
R
E
V
GGIS
A
L
T
AL
E
ML
SA
D
E
K
S
EV
L
A
FV
SKPPA
E
AV
RL
KI
VNAM
KA
T
GKP
T
VA
L
FLG
YT
P
AVARDE
NV
W
FA
SSLD
EAA
RL
A
C
L
L
---
------------SRV
T
ARR
NA
IA
--
PVSSGF
I
C
GL
Y
T
GGTL
A
A
EA
AG
LL
AGHL
G
VE
A
-
--
---
D
DTHH
H
GM
M
LD
A
DG
H
Q
I
I
D
L
GDD
FY
T
V
G
R
PHPMIDP
A
LRN
Q
LI
A
D
L
GA
K
P
Q
V
R
VLL
L
D
V
V
I
GFGA
TA
DPA
A
SLV
S
A
WQ
KA
C
A
-
A
RS
D
S
Q
PL
YA
IA
T
V
T
GTE
R
DPQ
C
RSQQI
AT
L
E
DAG
IA
V
V
SS
LPE
A
T
LLAAALI
fig|566546.4.peg.595
Escherichia coli W (6-493/555)
IK
K
G
C
F
QDSVSLM
I
IS
R
K
L
S
ES
E
N
VD
DV
SV
M
MGTP
A
NK
AL
L
DTT
G
F
WHDDFN
NA
T
PND
I
C
V
AI
R
S
E
AADA
GI
A
Q
AI
-
M
QQL
EE
A
L
K
Q
LAQG
SG
--
S
S
Q
SL
T
QVRR
WD
SA
C
Q
KL
S
D
ANLALISV
A
G
E
YAA
E
L
A
N
QAL
DRN
LNVMMFSDNV
T
LEDE
IQ
LKT
R
AREKGLLVMGPDCGT
SM
I
AA
T
PL
A
FANV
M
P
E
GNIGVIGASGTG
I
QEL
CS
Q
I
ALA
G
E
GI
TH
AIG
L
GGRDLS
R
E
V
GGIS
A
L
T
AL
E
ML
SA
D
E
K
S
EV
L
A
FV
SKPPA
E
AV
RL
KI
VNAM
KA
T
GKP
T
VA
L
FLG
YT
P
AVARDE
NV
W
FA
SSLD
EAA
RL
A
C
L
L
---
------------SRV
T
ARR
NA
IA
--
PVSSGF
I
C
GL
Y
T
GGTL
A
A
EA
AG
LL
AGHL
G
VE
A
-
--
---
D
DTHH
H
GM
M
LD
A
DG
H
Q
I
I
D
L
GDD
FY
T
V
G
R
PHPMIDP
A
LRN
Q
LI
A
D
L
GA
K
P
Q
V
R
VLL
L
D
V
V
I
GFGA
TA
DPA
A
SLV
S
A
WQ
KA
C
A
-
A
RS
D
S
Q
PL
YA
IA
T
V
T
GTE
R
DPQ
C
RSQQI
AT
L
E
DAG
IA
V
V
SS
LPE
A
T
LLAAALI
fig|679206.4.peg.28
Escherichia coli MS 119-7 (6-493/555)
IK
K
G
C
F
QDSVSLM
I
IS
R
K
L
S
ES
E
N
VD
DV
SV
M
MGTP
A
NK
AL
L
DTT
G
F
WHDDFN
NA
T
PND
I
C
V
AI
R
S
E
AADA
GI
A
Q
AI
-
M
QQL
EE
A
L
K
Q
LAQG
SG
--
S
S
Q
SL
T
QVRR
WD
SA
C
Q
KL
S
D
ANLALISV
A
G
E
YAA
E
L
T
N
QAL
DRN
LNVMMFSDNV
T
LEDE
IQ
LKT
R
AREKGLLVMGPDCGT
SM
I
A
G
T
PL
A
FANV
M
P
E
GNIGVIGASGTG
I
QEL
CS
Q
I
ALA
G
E
GI
TH
AIG
L
GGRDLS
R
E
V
GGIS
A
L
T
AL
E
ML
SA
D
E
K
S
EV
L
A
FV
SKPPA
E
AV
RL
KI
VNAM
KA
T
GKP
M
VA
L
FLG
YT
P
AVARDE
NV
W
FA
SSLD
EAA
RL
A
C
L
L
---
------------SRV
T
ARR
NA
IT
--
PASSGF
I
C
GL
Y
T
GGTL
A
A
EA
AG
LL
AGHL
G
VE
A
-
--
---
D
DTHH
H
GM
M
LD
A
DG
H
Q
I
I
D
L
GDD
FY
T
V
G
R
PHPMIDP
A
LRN
Q
LI
A
D
L
GA
K
P
Q
V
R
VLL
L
D
V
V
I
GFGA
TA
DPA
A
SLV
S
A
WQ
KA
C
A
-
A
RS
DN
Q
PL
YA
IA
T
V
T
GTE
R
DPQ
C
RSQQI
AT
L
E
DAG
IA
V
V
SS
LPE
A
T
LLAAALI
fig|656408.3.peg.463
Escherichia coli H591 (6-493/555)
IK
K
G
C
F
QDSVSLM
I
IS
R
K
L
S
ES
E
N
VD
DV
SV
M
MGTP
A
NK
AL
L
DTT
G
F
WHDDFN
NA
T
PND
I
C
V
AI
R
S
E
AADA
GI
A
Q
AI
-
M
QQL
EE
A
L
K
Q
LAQG
SG
--
S
S
Q
SL
T
QVRR
WD
SA
C
Q
KL
S
D
ANLALISV
A
G
E
YAA
E
L
T
N
QAL
DRN
LNVMMFSDNV
T
LEDE
IQ
LKT
R
AREKGLLVMGPDCGT
SM
I
A
G
T
PL
A
FANV
M
P
E
GNIGVIGASGTG
I
QEL
CS
Q
I
ALA
G
E
GI
TH
AIG
L
GGRDLS
R
E
V
GGIS
A
L
T
AL
E
ML
SA
D
E
K
S
EV
L
A
FV
SKPPA
E
AV
RL
KI
VNAM
KA
T
GKP
T
VA
L
FLG
YT
P
AVARDE
NV
W
FA
SSLD
EAA
RL
A
C
L
L
---
------------SRV
T
ARR
NA
IT
--
PASSGF
I
C
GL
Y
T
GGTL
A
A
EA
AG
LL
AGHL
G
VE
A
-
--
---
D
DTHH
H
GM
M
LD
A
DG
H
Q
I
I
D
L
GDD
FY
T
V
G
R
PHPMIDP
A
LRN
Q
LI
A
D
L
GA
K
P
Q
V
R
VLL
L
D
V
V
I
GFGA
TA
DPA
A
SLV
S
A
WQ
KA
C
A
-
A
RS
DN
Q
PL
YA
IA
T
V
T
GTE
R
DPQ
C
RSQQI
AT
L
E
DAG
IA
V
V
SS
LPE
A
T
LLAAALI
fig|656443.3.peg.777
Escherichia coli TA271 (6-493/550)
IK
K
G
C
F
QDSVSLM
I
IS
R
K
L
S
ES
E
N
VD
DV
SV
M
MGTP
A
NK
AL
L
DTT
G
F
WHDDFN
NA
T
PND
I
C
V
AI
R
S
E
AADA
GI
A
Q
AI
-
M
QQL
EE
A
L
K
Q
LAQG
SG
--
S
S
Q
SL
T
QVRR
WD
SA
C
Q
KL
S
D
ANLALISV
A
G
E
YAA
E
L
T
N
QAL
DRN
LNVMMFSDNV
T
LEDE
IQ
LKT
R
AREKGLLVMGPDCGT
SM
I
A
G
T
PL
A
FANV
M
P
E
GNIGVIGASGTG
I
QEL
CS
Q
I
ALA
G
E
GI
TH
AIG
L
GGRDLS
R
E
V
GGIS
A
L
T
AL
E
ML
SA
D
E
K
S
EV
L
A
FV
SKPPA
E
AV
RL
KI
VNAM
KA
T
GKP
T
VA
L
FLG
YT
P
AVARDE
NV
W
FA
SSLD
EAA
RL
A
C
L
L
---
------------SRV
T
ARR
NA
IT
--
PASSGF
I
C
GL
Y
T
GGTL
A
A
EA
AG
LL
AGHL
G
VE
A
-
--
---
D
DTHH
H
GM
M
LD
A
DG
H
Q
I
I
D
L
GDD
FY
T
V
G
R
PHPMIDP
A
LRN
Q
LI
A
D
L
GA
K
P
Q
V
R
VLL
L
D
V
V
I
GFGA
TA
DPA
A
SLV
S
A
WQ
KA
C
A
-
A
RS
DN
Q
PL
YA
IA
T
V
T
GTE
R
DPQ
C
RSQQI
AT
L
E
DAG
IA
V
V
SS
LPE
A
T
LLAAALI
fig|413997.3.peg.500
Escherichia coli B str. REL606 (6-493/555)
IK
K
G
C
F
QDSVSLM
I
IS
R
K
L
S
ES
E
N
VD
DV
SV
M
MGTP
A
NK
AL
L
DTT
G
F
WHDDFN
NA
T
PND
I
C
V
AI
R
S
E
AADA
GI
A
Q
AI
-
M
QQL
EE
A
L
K
Q
LAQG
SG
--
S
S
Q
SL
T
QVRR
WD
SA
C
Q
KL
S
D
ANLALISV
A
G
E
YAA
E
L
A
N
QAL
DRN
LNVMMFSDNV
T
LEDE
IQ
LKT
R
AREKGLLVMGPDCGT
SM
I
AA
T
PL
A
FANV
M
P
E
GNIGVIGASGTG
I
QEL
CS
Q
I
ALA
G
E
GI
TH
AIG
L
GGRDLS
R
E
V
GGIS
A
L
T
AL
E
ML
SA
D
E
K
S
EV
L
A
FV
SKPPA
E
AV
RL
KI
VNAM
KA
T
GKP
T
VA
L
FLG
YT
P
AVARDE
NV
W
FA
SSLD
EAA
RL
A
C
L
L
---
------------SRV
T
ARR
NA
IT
--
PASSGF
I
C
GL
Y
T
GGTL
A
A
EA
AG
LL
AGHL
G
VE
A
-
--
---
D
DTHH
H
GM
M
LD
A
DD
H
Q
I
I
D
L
GDD
FY
T
V
G
R
PHPMIDP
A
LRN
Q
LI
A
D
L
GA
K
P
Q
V
R
VLL
L
D
V
V
I
GFGA
TA
DPA
A
SLV
S
A
WQ
KA
C
A
-
A
RS
D
S
Q
PL
YA
IA
T
V
T
GTE
R
DPQ
C
RSQQI
AT
L
E
DAG
IA
V
V
SS
LPE
A
T
LLAAALI
fig|511693.5.peg.506
Escherichia coli BL21 (6-493/555)
IK
K
G
C
F
QDSVSLM
I
IS
R
K
L
S
ES
E
N
VD
DV
SV
M
MGTP
A
NK
AL
L
DTT
G
F
WHDDFN
NA
T
PND
I
C
V
AI
R
S
E
AADA
GI
A
Q
AI
-
M
QQL
EE
A
L
K
Q
LAQG
SG
--
S
S
Q
SL
T
QVRR
WD
SA
C
Q
KL
S
D
ANLALISV
A
G
E
YAA
E
L
A
N
QAL
DRN
LNVMMFSDNV
T
LEDE
IQ
LKT
R
AREKGLLVMGPDCGT
SM
I
AA
T
PL
A
FANV
M
P
E
GNIGVIGASGTG
I
QEL
CS
Q
I
ALA
G
E
GI
TH
AIG
L
GGRDLS
R
E
V
GGIS
A
L
T
AL
E
ML
SA
D
E
K
S
EV
L
A
FV
SKPPA
E
AV
RL
KI
VNAM
KA
T
GKP
T
VA
L
FLG
YT
P
AVARDE
NV
W
FA
SSLD
EAA
RL
A
C
L
L
---
------------SRV
T
ARR
NA
IT
--
PASSGF
I
C
GL
Y
T
GGTL
A
A
EA
AG
LL
AGHL
G
VE
A
-
--
---
D
DTHH
H
GM
M
LD
A
DD
H
Q
I
I
D
L
GDD
FY
T
V
G
R
PHPMIDP
A
LRN
Q
LI
A
D
L
GA
K
P
Q
V
R
VLL
L
D
V
V
I
GFGA
TA
DPA
A
SLV
S
A
WQ
KA
C
A
-
A
RS
D
S
Q
PL
YA
IA
T
V
T
GTE
R
DPQ
C
RSQQI
AT
L
E
DAG
IA
V
V
SS
LPE
A
T
LLAAALI
fig|469008.4.peg.3245
Escherichia coli BL21(DE3) (6-493/555)
IK
K
G
C
F
QDSVSLM
I
IS
R
K
L
S
ES
E
N
VD
DV
SV
M
MGTP
A
NK
AL
L
DTT
G
F
WHDDFN
NA
T
PND
I
C
V
AI
R
S
E
AADA
GI
A
Q
AI
-
M
QQL
EE
A
L
K
Q
LAQG
SG
--
S
S
Q
SL
T
QVRR
WD
SA
C
Q
KL
S
D
ANLALISV
A
G
E
YAA
E
L
A
N
QAL
DRN
LNVMMFSDNV
T
LEDE
IQ
LKT
R
AREKGLLVMGPDCGT
SM
I
AA
T
PL
A
FANV
M
P
E
GNIGVIGASGTG
I
QEL
CS
Q
I
ALA
G
E
GI
TH
AIG
L
GGRDLS
R
E
V
GGIS
A
L
T
AL
E
ML
SA
D
E
K
S
EV
L
A
FV
SKPPA
E
AV
RL
KI
VNAM
KA
T
GKP
T
VA
L
FLG
YT
P
AVARDE
NV
W
FA
SSLD
EAA
RL
A
C
L
L
---
------------SRV
T
ARR
NA
IT
--
PASSGF
I
C
GL
Y
T
GGTL
A
A
EA
AG
LL
AGHL
G
VE
A
-
--
---
D
DTHH
H
GM
M
LD
A
DD
H
Q
I
I
D
L
GDD
FY
T
V
G
R
PHPMIDP
A
LRN
Q
LI
A
D
L
GA
K
P
Q
V
R
VLL
L
D
V
V
I
GFGA
TA
DPA
A
SLV
S
A
WQ
KA
C
A
-
A
RS
D
S
Q
PL
YA
IA
T
V
T
GTE
R
DPQ
C
RSQQI
AT
L
E
DAG
IA
V
V
SS
LPE
A
T
LLAAALI
fig|637912.3.peg.1052
Escherichia coli OP50 (6-493/555)
IK
K
G
C
F
QDSVSLM
I
IS
R
K
L
S
ES
E
N
VD
DV
SV
M
MGTP
A
NK
AL
L
DTT
G
F
WHDDFN
NA
T
PND
I
C
V
AI
R
S
E
AADA
GI
A
Q
AI
-
M
QQL
EE
A
L
K
Q
LAQG
SG
--
S
S
Q
SL
T
QVRR
WD
SA
C
Q
KL
S
D
ANLALISV
A
G
E
YAA
E
L
A
N
QAL
DRN
LNVMMFSDNV
T
LEDE
IQ
LKT
R
AREKGLLVMGPDCGT
SM
I
AA
T
PL
A
FANV
M
P
E
GNIGVIGASGTG
I
QEL
CS
Q
I
ALA
G
E
GI
TH
AIG
L
GGRDLS
R
E
V
GGIS
A
L
T
AL
E
ML
SA
D
E
K
S
EV
L
A
FV
SKPPA
E
AV
RL
KI
VNAM
KA
T
GKP
T
VA
L
FLG
YT
P
AVARDE
NV
W
FA
SSLD
EAA
RL
A
C
L
L
---
------------SRV
T
ARR
NA
IT
--
PASSGF
I
C
GL
Y
T
GGTL
A
A
EA
AG
LL
AGHL
G
VE
A
-
--
---
D
DTHH
H
GM
M
LD
A
DD
H
Q
I
I
D
L
GDD
FY
T
V
G
R
PHPMIDP
A
LRN
Q
LI
A
D
L
GA
K
P
Q
V
R
VLL
L
D
V
V
I
GFGA
TA
DPA
A
SLV
S
A
WQ
KA
C
A
-
A
RS
D
S
Q
PL
YA
IA
T
V
T
GTE
R
DPQ
C
RSQQI
AT
L
E
DAG
IA
V
V
SS
LPE
A
T
LLAAALI
fig|340184.3.peg.3216
Escherichia coli B7A (6-493/555)
IK
K
G
C
F
QDSVSLM
I
IS
R
K
L
S
ES
E
N
VD
DV
SV
M
MGTP
A
NK
AL
L
DTT
G
F
WHDDFN
NA
T
PND
I
C
V
AI
R
S
E
AADA
GI
A
Q
AI
-
M
QQL
EE
A
L
K
Q
LAQG
SG
--
S
S
Q
SL
T
QVRR
WD
SA
C
Q
KL
S
D
A
S
LALISV
A
G
E
YAA
E
L
A
N
QAL
DRN
LNVMMFSDNV
T
LEDE
IQ
LKT
R
AREKGLLVMGPDCGT
SM
I
A
G
T
PL
A
FANV
M
P
E
GNIGVIGASGTG
I
QEL
CS
Q
I
ALA
G
E
GI
TH
AIG
L
GGRDLS
R
E
V
GGIS
A
L
T
AL
E
ML
SA
D
E
K
S
EV
L
A
FV
SKPPA
E
AV
RL
KI
VNAM
KA
T
GKP
T
VA
L
FLG
YT
P
AVARDE
NV
W
FA
SSLD
EAA
RL
A
C
L
L
---
------------SRV
T
ARR
NA
IT
--
PASSGF
I
C
GL
Y
T
GGTL
A
A
EA
AG
LL
AGHL
G
VE
A
-
--
---
D
DTHH
H
GM
M
LD
A
DG
H
Q
I
I
D
L
GDD
FY
T
V
G
R
PHPMIDP
A
LRN
Q
LI
A
D
L
GA
K
P
Q
V
R
VLL
L
D
V
V
I
GFGA
TA
DPA
A
SLV
S
A
WQ
KA
C
A
-
A
RS
DN
Q
PL
YA
IA
T
V
T
GTE
R
DPQ
C
RSQQI
AT
L
E
DAG
IA
V
V
SS
LPE
A
T
LLAAALI
fig|340184.6.peg.3356
Escherichia coli B7A (6-493/555)
IK
K
G
C
F
QDSVSLM
I
IS
R
K
L
S
ES
E
N
VD
DV
SV
M
MGTP
A
NK
AL
L
DTT
G
F
WHDDFN
NA
T
PND
I
C
V
AI
R
S
E
AADA
GI
A
Q
AI
-
M
QQL
EE
A
L
K
Q
LAQG
SG
--
S
S
Q
SL
T
QVRR
WD
SA
C
Q
KL
S
D
A
S
LALISV
A
G
E
YAA
E
L
A
N
QAL
DRN
LNVMMFSDNV
T
LEDE
IQ
LKT
R
AREKGLLVMGPDCGT
SM
I
A
G
T
PL
A
FANV
M
P
E
GNIGVIGASGTG
I
QEL
CS
Q
I
ALA
G
E
GI
TH
AIG
L
GGRDLS
R
E
V
GGIS
A
L
T
AL
E
ML
SA
D
E
K
S
EV
L
A
FV
SKPPA
E
AV
RL
KI
VNAM
KA
T
GKP
T
VA
L
FLG
YT
P
AVARDE
NV
W
FA
SSLD
EAA
RL
A
C
L
L
---
------------SRV
T
ARR
NA
IT
--
PASSGF
I
C
GL
Y
T
GGTL
A
A
EA
AG
LL
AGHL
G
VE
A
-
--
---
D
DTHH
H
GM
M
LD
A
DG
H
Q
I
I
D
L
GDD
FY
T
V
G
R
PHPMIDP
A
LRN
Q
LI
A
D
L
GA
K
P
Q
V
R
VLL
L
D
V
V
I
GFGA
TA
DPA
A
SLV
S
A
WQ
KA
C
A
-
A
RS
DN
Q
PL
YA
IA
T
V
T
GTE
R
DPQ
C
RSQQI
AT
L
E
DAG
IA
V
V
SS
LPE
A
T
LLAAALI
fig|679204.3.peg.4288
Escherichia coli MS 145-7 (6-493/555)
IK
K
G
C
F
QDSVSLM
I
IS
R
K
L
S
ES
E
N
VD
DV
SV
M
MGTP
A
NK
AL
L
DTT
G
F
WHDDFN
NA
T
PND
I
C
V
AI
R
S
E
AADA
GI
A
Q
AI
-
M
QQL
EE
A
L
K
Q
LAQG
SG
--
S
S
Q
SL
T
QVRR
WD
SA
C
Q
KL
S
D
A
S
LALISV
A
G
E
YAA
E
L
A
N
QAL
DRN
LNVMMFSDNV
T
LEDE
IQ
LKT
R
AREKGLLVMGPDCGT
SM
I
A
G
T
PL
A
FANV
M
P
E
GNIGVIGASGTG
I
QEL
CS
Q
I
ALA
G
E
GI
TH
AIG
L
GGRDLS
R
E
V
GGIS
A
L
T
AL
E
ML
SA
D
E
K
S
EV
L
A
FV
SKPPA
E
AV
RL
KI
VNAM
KA
T
GKP
T
VA
L
FLG
YT
P
AVARDE
NV
W
FA
SSLD
EAA
RL
A
C
L
L
---
------------SRV
T
ARR
NA
IT
--
PASSGF
I
C
GL
Y
T
GGTL
A
A
EA
AG
LL
AGHL
G
VE
A
-
--
---
D
DTHH
H
GM
M
LD
A
DG
H
Q
I
I
D
L
GDD
FY
T
V
G
R
PHPMIDP
A
LRN
Q
LI
A
D
L
GA
K
P
Q
V
R
VLL
L
D
V
V
I
GFGA
TA
DPA
A
SLV
S
A
WQ
KA
C
A
-
A
RS
DN
Q
PL
YA
IA
T
V
T
GTE
R
DPQ
C
RSQQI
AT
L
E
DAG
IA
V
V
SS
LPE
A
T
LLAAALI
fig|358709.5.peg.2033
Escherichia coli 101-1 (6-493/555)
IK
K
G
C
F
QDSVSLM
I
IS
R
K
L
S
ES
E
N
VD
DV
SV
M
MGTP
A
NK
AL
L
DTT
G
F
WHDDFN
NA
T
PND
I
C
V
AI
R
S
E
AADA
GI
A
Q
AI
-
M
QQL
EE
A
L
K
Q
LAQG
SG
--
S
S
Q
SL
T
QVRR
WD
SA
C
Q
KL
S
D
ANLALISV
A
G
E
YAA
E
L
A
N
QAL
DRN
LNVMMFSDNV
T
LEDE
IQ
LKT
R
AREKGLLVMGPDCGT
SM
I
AA
T
PL
A
FANV
M
P
E
GNIGVIGASGTG
I
QEL
CS
Q
I
ALA
G
E
GI
TH
AIG
L
GGRDLS
R
E
V
GGIS
A
L
T
AL
E
ML
SA
D
E
K
S
EV
L
A
FV
SKPPA
E
AV
RL
KI
VNAM
KA
T
GKP
T
VA
L
FLG
YT
P
AVARDE
NV
W
FA
SSLD
EAA
RL
A
C
L
L
---
------------SRV
T
ARR
NA
IT
--
PASSGF
I
C
GL
Y
T
GGTL
A
A
EA
AG
LL
AGHL
G
VE
A
-
--
---
D
DTHH
H
GM
M
LD
A
DG
H
Q
I
I
D
L
GDD
FY
T
V
G
R
PHPMIDP
A
LRN
Q
LI
A
D
L
GA
K
P
Q
V
R
VLL
L
D
V
V
I
GFGA
TA
DPA
A
SLV
S
A
WQ
KA
C
A
-
A
RS
D
S
Q
PL
YA
IA
T
V
T
GTE
R
DPQ
C
RSQQI
AT
L
E
DAG
IA
V
V
SS
LPE
A
T
LLAAALI
fig|679207.4.peg.4480
Escherichia coli MS 107-1 (6-493/555)
IK
K
G
C
F
QDSVSLM
I
IS
R
K
L
S
ES
E
N
VD
DV
SV
M
MGTP
A
NK
AL
L
DTT
G
F
WHDDFN
NA
T
PND
I
C
V
AI
R
S
E
AADA
GI
A
Q
AI
-
M
QQL
EE
A
L
K
Q
LAQG
SG
--
S
S
Q
SL
T
QVRR
WD
SA
C
Q
KL
S
D
ANLALISV
A
G
E
YAA
E
L
A
N
QAL
DRN
LNVMMFSDNV
T
LEDE
IQ
LKT
R
AREKGLLVMGPDCGT
SM
I
AA
T
PL
A
FANV
M
P
E
GNIGVIGASGTG
I
QEL
CS
Q
I
ALA
G
E
GI
TH
AIG
L
GGRDLS
R
E
V
GGIS
A
L
T
AL
E
ML
SA
D
E
K
S
EV
L
A
FV
SKPPA
E
AV
RL
KI
VNAM
KA
T
GKP
T
VA
L
FLG
YT
P
AVARDE
NV
W
FA
SSLD
EAA
RL
A
C
L
L
---
------------SRV
T
ARR
NA
IT
--
PASSGF
I
C
GL
Y
T
GGTL
A
A
EA
AG
LL
AGHL
G
VE
A
-
--
---
D
DTHH
H
GM
M
LD
A
DG
H
Q
I
I
D
L
GDD
FY
T
V
G
R
PHPMIDP
A
LRN
Q
LI
A
D
L
GA
K
P
Q
V
R
VLL
L
D
V
V
I
GFGA
TA
DPA
A
SLV
S
A
WQ
KA
C
A
-
A
RS
D
S
Q
PL
YA
IA
T
V
T
GTE
R
DPQ
C
RSQQI
AT
L
E
DAG
IA
V
V
SS
LPE
A
T
LLAAALI
fig|749547.3.peg.1403
Escherichia coli MS 187-1 (6-493/555)
IK
K
G
C
F
QDSVSLM
I
IS
R
K
L
S
ES
E
N
VD
DV
SV
M
MGTP
A
NK
AL
L
DTT
G
F
WHDDFN
NA
T
PND
I
C
V
AI
R
S
E
AADA
GI
A
Q
AI
-
M
QQL
EE
A
L
K
Q
LAQG
SG
--
S
S
Q
SL
T
QVRR
WD
SA
C
Q
KL
S
D
ANLALISV
A
G
E
YAA
E
L
A
N
QAL
DRN
LNVMMFSDNV
T
LEDE
IQ
LKT
R
AREKGLLVMGPDCGT
SM
I
AA
T
PL
A
FANV
M
P
E
GNIGVIGASGTG
I
QEL
CS
Q
I
ALA
G
E
GI
TH
AIG
L
GGRDLS
R
E
V
GGIS
A
L
T
AL
E
ML
SA
D
E
K
S
EV
L
A
FV
SKPPA
E
AV
RL
KI
VNAM
KA
T
GKP
T
VA
L
FLG
YT
P
AVARDE
NV
W
FA
SSLD
EAA
RL
A
C
L
L
---
------------SRV
T
ARR
NA
IT
--
PASSGF
I
C
GL
Y
T
GGTL
A
A
EA
AG
LL
AGHL
G
VE
A
-
--
---
D
DTHH
H
GM
M
LD
A
DG
H
Q
I
I
D
L
GDD
FY
T
V
G
R
PHPMIDP
A
LRN
Q
LI
A
D
L
GA
K
P
Q
V
R
VLL
L
D
V
V
I
GFGA
TA
DPA
A
SLV
S
A
WQ
KA
C
A
-
A
RS
D
S
Q
PL
YA
IA
T
V
T
GTE
R
DPQ
C
RSQQI
AT
L
E
DAG
IA
V
V
SS
LPE
A
T
LLAAALI
fig|585034.4.peg.518
Escherichia coli IAI1 (6-493/555)
IK
K
G
C
F
QDSVSLM
I
IS
R
K
L
S
ES
E
N
VD
DV
SV
M
MGTP
A
NK
AL
L
DTT
G
F
WHDDFN
NA
T
PND
I
C
V
AI
R
S
E
AADA
GI
A
Q
AI
-
M
QQL
EE
A
L
K
Q
LAQG
SG
--
S
S
Q
SL
T
QVRR
WD
SA
C
Q
KL
S
D
A
S
LALISV
A
G
E
YAA
E
L
A
N
QAL
DRN
LNVMMFSDNV
T
LEDE
IQ
LKT
R
AREKGLLVMGPDCGT
SM
I
A
G
T
PL
A
FANV
M
P
E
GNIGVIGASGTG
I
QEL
CS
Q
I
ALA
G
E
GI
TH
AIG
L
GGRDLS
R
E
V
GGIS
A
L
T
AL
E
ML
SA
D
E
K
S
EV
L
A
FV
SKPPA
E
AV
RL
KI
VNAM
KA
T
GKP
T
VA
L
FLG
YT
P
AVACDE
NV
W
FA
SSLD
EAA
RL
A
C
L
L
---
------------SRV
T
ARR
NA
IT
--
PASSGF
I
C
GL
Y
T
GGTL
A
A
EA
AG
LL
AGHL
G
VE
A
-
--
---
D
DTHH
H
GM
M
LD
A
DG
H
Q
I
I
D
L
GDD
FY
T
V
G
R
PHPMIDP
A
LRN
Q
LI
A
D
L
GA
K
P
Q
V
R
VLL
L
D
V
V
I
GFGA
TA
DPA
A
SLV
S
A
WQ
KA
C
A
-
A
RS
D
S
Q
PL
YA
IA
T
V
T
GTE
R
DPQ
C
RSQQI
AT
L
E
DAG
IA
V
V
SS
LPE
A
T
LLAAALI
fig|585034.5.peg.517
Escherichia coli IAI1 (6-493/555)
IK
K
G
C
F
QDSVSLM
I
IS
R
K
L
S
ES
E
N
VD
DV
SV
M
MGTP
A
NK
AL
L
DTT
G
F
WHDDFN
NA
T
PND
I
C
V
AI
R
S
E
AADA
GI
A
Q
AI
-
M
QQL
EE
A
L
K
Q
LAQG
SG
--
S
S
Q
SL
T
QVRR
WD
SA
C
Q
KL
S
D
A
S
LALISV
A
G
E
YAA
E
L
A
N
QAL
DRN
LNVMMFSDNV
T
LEDE
IQ
LKT
R
AREKGLLVMGPDCGT
SM
I
A
G
T
PL
A
FANV
M
P
E
GNIGVIGASGTG
I
QEL
CS
Q
I
ALA
G
E
GI
TH
AIG
L
GGRDLS
R
E
V
GGIS
A
L
T
AL
E
ML
SA
D
E
K
S
EV
L
A
FV
SKPPA
E
AV
RL
KI
VNAM
KA
T
GKP
T
VA
L
FLG
YT
P
AVACDE
NV
W
FA
SSLD
EAA
RL
A
C
L
L
---
------------SRV
T
ARR
NA
IT
--
PASSGF
I
C
GL
Y
T
GGTL
A
A
EA
AG
LL
AGHL
G
VE
A
-
--
---
D
DTHH
H
GM
M
LD
A
DG
H
Q
I
I
D
L
GDD
FY
T
V
G
R
PHPMIDP
A
LRN
Q
LI
A
D
L
GA
K
P
Q
V
R
VLL
L
D
V
V
I
GFGA
TA
DPA
A
SLV
S
A
WQ
KA
C
A
-
A
RS
D
S
Q
PL
YA
IA
T
V
T
GTE
R
DPQ
C
RSQQI
AT
L
E
DAG
IA
V
V
SS
LPE
A
T
LLAAALI
fig|344601.3.peg.3917
Escherichia coli B171 (6-493/555)
IK
K
G
C
F
QDSVSLM
I
IS
R
K
L
S
ES
E
N
VD
DV
SV
M
MGTP
A
NK
AL
L
DTT
G
F
WHDDFN
NA
T
PND
I
C
V
AI
R
S
E
AADA
GI
A
Q
AI
-
M
QQL
EE
A
L
K
Q
LAQG
SG
--
S
S
Q
SL
T
QVRR
WD
SA
C
Q
KL
S
D
A
S
LALISV
A
G
E
YAA
E
L
A
N
QAL
DRN
LNVMMFSDNV
T
LEDE
IQ
LKT
R
AREKGLLVMGPDCGT
SM
I
A
G
T
PL
A
FANV
M
P
E
GNIGVIGASGTG
I
QEL
CS
Q
I
ALA
G
E
GI
TH
AIG
L
GGRDLS
R
E
V
GGIS
A
L
T
AL
E
ML
SA
D
E
K
S
EV
L
A
FV
SKPPA
E
AV
RL
KI
VNAM
KA
T
GKP
T
VA
L
FLG
YT
P
AVACDE
NV
W
FA
SSLD
EAA
RL
A
C
L
L
---
------------SRV
T
ARR
NA
IT
--
PASSGF
I
C
GL
Y
T
GGTL
A
A
EA
AG
LL
AGHL
G
VE
A
-
--
---
D
DTHH
H
GM
M
LD
A
DG
H
Q
I
I
D
L
GDD
FY
T
V
G
R
PHPMIDP
A
LRN
Q
LI
A
D
L
GA
K
P
Q
V
R
VLL
L
D
V
V
I
GFGA
TA
DPA
A
SLV
S
A
WQ
KA
C
A
-
A
RS
DN
Q
PL
YA
IA
T
V
T
GTE
R
DPQ
C
RSQQI
AT
L
E
DAG
IA
V
V
SS
LPE
A
T
LLAAALI
fig|344601.5.peg.4109
Escherichia coli B171 (6-493/555)
IK
K
G
C
F
QDSVSLM
I
IS
R
K
L
S
ES
E
N
VD
DV
SV
M
MGTP
A
NK
AL
L
DTT
G
F
WHDDFN
NA
T
PND
I
C
V
AI
R
S
E
AADA
GI
A
Q
AI
-
M
QQL
EE
A
L
K
Q
LAQG
SG
--
S
S
Q
SL
T
QVRR
WD
SA
C
Q
KL
S
D
A
S
LALISV
A
G
E
YAA
E
L
A
N
QAL
DRN
LNVMMFSDNV
T
LEDE
IQ
LKT
R
AREKGLLVMGPDCGT
SM
I
A
G
T
PL
A
FANV
M
P
E
GNIGVIGASGTG
I
QEL
CS
Q
I
ALA
G
E
GI
TH
AIG
L
GGRDLS
R
E
V
GGIS
A
L
T
AL
E
ML
SA
D
E
K
S
EV
L
A
FV
SKPPA
E
AV
RL
KI
VNAM
KA
T
GKP
T
VA
L
FLG
YT
P
AVACDE
NV
W
FA
SSLD
EAA
RL
A
C
L
L
---
------------SRV
T
ARR
NA
IT
--
PASSGF
I
C
GL
Y
T
GGTL
A
A
EA
AG
LL
AGHL
G
VE
A
-
--
---
D
DTHH
H
GM
M
LD
A
DG
H
Q
I
I
D
L
GDD
FY
T
V
G
R
PHPMIDP
A
LRN
Q
LI
A
D
L
GA
K
P
Q
V
R
VLL
L
D
V
V
I
GFGA
TA
DPA
A
SLV
S
A
WQ
KA
C
A
-
A
RS
DN
Q
PL
YA
IA
T
V
T
GTE
R
DPQ
C
RSQQI
AT
L
E
DAG
IA
V
V
SS
LPE
A
T
LLAAALI
fig|331111.12.peg.862
Escherichia coli E24377A (6-493/555)
IK
K
G
C
F
QDSVSLM
I
IS
R
K
L
S
ES
E
N
VD
DV
SV
M
MGTP
A
NK
AL
L
DTT
G
F
WHDDFN
NA
T
PND
I
C
V
AI
R
S
E
AADA
GI
A
R
AI
-
M
QQL
EE
A
L
K
Q
LAQG
SG
--
S
S
Q
SL
T
QVRR
WD
SA
C
Q
KL
S
D
ANLALISV
A
G
E
YAA
E
L
A
N
QAL
DRN
LNVMMFSDNV
T
LEDE
IQ
LKT
R
AREKGLLVMGPDCGT
SM
I
AA
T
PL
A
FANV
M
P
E
GNIGVIGASGTG
I
QEL
CS
Q
I
ALA
G
E
GI
TH
AIG
L
GGRDLS
R
E
V
GGIS
A
L
T
AL
E
ML
SA
D
E
K
S
EV
L
A
FV
SKPPA
E
AV
RL
KI
VNAM
KA
T
GKP
T
VA
L
FLG
YT
P
AVARDE
NV
W
FA
SSLD
EAA
RL
A
C
L
L
---
------------SRV
T
ARR
NA
IT
--
PASSGF
I
C
GL
Y
T
GGTL
A
A
EA
AG
LL
AGHL
G
VE
A
-
--
---
D
DTHH
H
GM
M
LD
A
DG
H
Q
I
I
D
L
GDD
FY
T
V
G
R
PHPMIDP
A
LRN
Q
LI
A
D
L
GA
K
P
Q
V
R
VLL
L
D
V
V
I
GFGA
TA
DPA
A
SLV
S
A
WQ
KA
C
A
-
A
RS
D
S
Q
PL
YA
IA
T
V
T
GTE
R
DPQ
C
RSQQI
AT
L
E
DAG
IA
V
V
SS
LPE
A
T
LLAAALI
fig|331111.3.peg.3089
Escherichia coli E24377A (6-493/555)
IK
K
G
C
F
QDSVSLM
I
IS
R
K
L
S
ES
E
N
VD
DV
SV
M
MGTP
A
NK
AL
L
DTT
G
F
WHDDFN
NA
T
PND
I
C
V
AI
R
S
E
AADA
GI
A
R
AI
-
M
QQL
EE
A
L
K
Q
LAQG
SG
--
S
S
Q
SL
T
QVRR
WD
SA
C
Q
KL
S
D
ANLALISV
A
G
E
YAA
E
L
A
N
QAL
DRN
LNVMMFSDNV
T
LEDE
IQ
LKT
R
AREKGLLVMGPDCGT
SM
I
AA
T
PL
A
FANV
M
P
E
GNIGVIGASGTG
I
QEL
CS
Q
I
ALA
G
E
GI
TH
AIG
L
GGRDLS
R
E
V
GGIS
A
L
T
AL
E
ML
SA
D
E
K
S
EV
L
A
FV
SKPPA
E
AV
RL
KI
VNAM
KA
T
GKP
T
VA
L
FLG
YT
P
AVARDE
NV
W
FA
SSLD
EAA
RL
A
C
L
L
---
------------SRV
T
ARR
NA
IT
--
PASSGF
I
C
GL
Y
T
GGTL
A
A
EA
AG
LL
AGHL
G
VE
A
-
--
---
D
DTHH
H
GM
M
LD
A
DG
H
Q
I
I
D
L
GDD
FY
T
V
G
R
PHPMIDP
A
LRN
Q
LI
A
D
L
GA
K
P
Q
V
R
VLL
L
D
V
V
I
GFGA
TA
DPA
A
SLV
S
A
WQ
KA
C
A
-
A
RS
D
S
Q
PL
YA
IA
T
V
T
GTE
R
DPQ
C
RSQQI
AT
L
E
DAG
IA
V
V
SS
LPE
A
T
LLAAALI
fig|340185.3.peg.2498
Escherichia coli E22 (6-493/555)
IK
K
G
C
F
QDSVSLM
I
IS
R
K
L
S
ES
E
N
VD
DV
SV
M
MGTP
A
NK
AL
L
DTT
G
F
WHDDFN
NA
T
PND
I
C
V
AI
R
S
E
AADA
GI
A
Q
AI
-
M
QQL
EE
A
L
K
Q
LAQG
SG
--
S
S
Q
SL
T
QVRR
WD
SA
C
Q
KL
S
D
A
S
LALISV
A
G
E
YAA
E
L
A
N
QAL
DRN
LNVMMFSDNV
T
LEDE
IQ
LKT
R
AREKGLLVMGPDCGT
SM
I
A
G
T
PL
A
FANV
M
P
E
GNIGVIGASGTG
I
QEL
CS
Q
I
ALA
G
E
GI
TH
AIG
L
GGRDLS
R
E
V
GGIS
A
L
T
AL
E
ML
SA
D
E
K
S
E
M
L
A
FV
SKPPA
E
AV
RL
KI
VNAM
KA
T
GKP
T
VA
L
FLG
YT
P
AVACDE
NV
W
FA
SSLD
EAA
RL
A
C
L
L
---
------------SRV
T
ARR
NA
IT
--
PASSGF
I
C
GL
Y
T
GGTL
A
A
EA
AG
LL
AGHL
G
VE
A
-
--
---
D
DTHH
H
GM
M
LD
A
DG
H
Q
I
I
D
L
GDD
FY
T
V
G
R
PHPMIDP
A
LRN
Q
LI
A
D
L
GA
K
P
Q
V
R
VLL
L
D
V
V
I
GFGA
TA
DPA
A
SLV
S
A
WQ
KA
C
A
-
A
RS
DN
Q
PL
YA
IA
T
V
T
GTE
R
DPQ
C
RSQQI
AT
L
E
DAG
IA
V
V
SS
LPE
A
T
LLAAALI
fig|340185.4.peg.2637
Escherichia coli E22 (6-493/555)
IK
K
G
C
F
QDSVSLM
I
IS
R
K
L
S
ES
E
N
VD
DV
SV
M
MGTP
A
NK
AL
L
DTT
G
F
WHDDFN
NA
T
PND
I
C
V
AI
R
S
E
AADA
GI
A
Q
AI
-
M
QQL
EE
A
L
K
Q
LAQG
SG
--
S
S
Q
SL
T
QVRR
WD
SA
C
Q
KL
S
D
A
S
LALISV
A
G
E
YAA
E
L
A
N
QAL
DRN
LNVMMFSDNV
T
LEDE
IQ
LKT
R
AREKGLLVMGPDCGT
SM
I
A
G
T
PL
A
FANV
M
P
E
GNIGVIGASGTG
I
QEL
CS
Q
I
ALA
G
E
GI
TH
AIG
L
GGRDLS
R
E
V
GGIS
A
L
T
AL
E
ML
SA
D
E
K
S
E
M
L
A
FV
SKPPA
E
AV
RL
KI
VNAM
KA
T
GKP
T
VA
L
FLG
YT
P
AVACDE
NV
W
FA
SSLD
EAA
RL
A
C
L
L
---
------------SRV
T
ARR
NA
IT
--
PASSGF
I
C
GL
Y
T
GGTL
A
A
EA
AG
LL
AGHL
G
VE
A
-
--
---
D
DTHH
H
GM
M
LD
A
DG
H
Q
I
I
D
L
GDD
FY
T
V
G
R
PHPMIDP
A
LRN
Q
LI
A
D
L
GA
K
P
Q
V
R
VLL
L
D
V
V
I
GFGA
TA
DPA
A
SLV
S
A
WQ
KA
C
A
-
A
RS
DN
Q
PL
YA
IA
T
V
T
GTE
R
DPQ
C
RSQQI
AT
L
E
DAG
IA
V
V
SS
LPE
A
T
LLAAALI
fig|585395.4.peg.517
Escherichia coli O103:H2 str. 12009 (6-493/555)
IK
K
G
C
F
QDSVSLM
I
IS
R
K
L
S
ES
E
N
VD
DV
SV
M
MGTP
A
NK
AL
L
DTT
G
F
WHDDFN
NA
T
PND
I
C
V
AI
R
S
E
AADA
GI
A
Q
AI
-
M
QQL
EE
A
L
K
Q
LAQG
SG
--
S
S
Q
SL
T
QVRR
WD
SA
C
Q
KL
S
D
A
S
LALISV
A
G
E
YAA
E
L
A
N
QAL
DRN
LNVMMFSDNV
T
LEDE
IQ
LKT
R
AREKGLLVMGPDCGT
SM
I
A
G
T
PL
A
FANV
M
P
E
GNIGVIGASGTG
I
QEL
CS
Q
I
ALA
G
E
GI
TH
AIG
L
GGRDLS
R
E
V
GGIS
A
L
T
AL
E
ML
SA
D
E
K
S
E
M
L
A
FV
SKPPA
E
AV
RL
KI
VNAM
KA
T
GKP
T
VA
L
FLG
YT
P
AVACDE
NV
W
FA
SSLD
EAA
RL
A
C
L
L
---
------------SRV
T
ARR
NA
IT
--
PASSGF
I
C
GL
Y
T
GGTL
A
A
EA
AG
LL
AGHL
G
VE
A
-
--
---
D
DTHH
H
GM
M
LD
A
DG
H
Q
I
I
D
L
GDD
FY
T
V
G
R
PHPMIDP
A
LRN
Q
LI
A
D
L
GA
K
P
Q
V
R
VLL
L
D
V
V
I
GFGA
TA
DPA
A
SLV
S
A
WQ
KA
C
A
-
A
RS
DN
Q
PL
YA
IA
T
V
T
GTE
R
DPQ
C
RSQQI
AT
L
E
DAG
IA
V
V
SS
LPE
A
T
LLAAALI
fig|562.373.peg.3205
Escherichia coli 1125A (6-490/552)
IK
K
G
C
F
QDSVSLM
I
IS
R
K
L
S
ES
E
N
VD
DV
SV
M
MGTP
A
NK
AL
L
DTT
G
F
WHDDFN
NA
T
PND
I
C
V
AI
R
S
E
AADA
GI
A
Q
AI
-
M
QQL
EE
A
L
K
Q
LAQG
SG
--
S
S
Q
AL
T
QVRR
WD
SA
C
Q
KL
P
D
ANLALISV
A
G
E
YAA
E
L
A
N
QAL
DRN
LNVMMFSDNV
T
LEDE
IQ
LKT
R
AREKGLLVMGPDCGT
SM
I
A
G
T
PL
A
FANV
M
P
E
GN
---
IGASGTG
I
QEL
CS
Q
I
ALA
G
E
GI
TH
AIG
L
GGRDLS
R
E
V
GGIS
A
L
T
AL
E
ML
SA
D
E
K
S
EV
L
A
FV
SKP
L
A
E
AV
RL
KI
VNAM
KA
T
GKP
T
VA
L
FLG
YT
P
AVARDE
NV
W
FA
SSLD
EAA
RL
A
C
L
L
---
------------SRV
T
ARR
NA
IM
--
PASSGF
I
C
GL
Y
T
GGTL
A
A
EA
AG
LL
AGHL
G
VE
A
-
--
---
D
DAHH
H
GM
M
LD
A
DG
H
Q
I
I
D
L
GDD
FY
T
V
G
R
PHPMIDPTLRN
Q
LI
T
D
L
GA
K
P
Q
V
R
VLL
L
D
V
V
I
GFGA
TA
DPA
A
SLV
S
A
WQ
KA
C
A
-
A
RS
DN
Q
PL
YA
IA
T
V
T
GTE
R
DPQ
C
RSQQI
AT
L
E
DAG
IA
V
V
SS
LPE
A
T
LLAAALI
fig|481805.3.peg.3324
Escherichia coli ATCC 8739 (6-493/555)
IK
K
G
C
F
QDSVSLM
I
IS
R
K
L
S
ES
E
N
VD
DV
SV
M
MGTP
A
NK
AL
L
DTT
G
F
WHDDFN
NA
T
PND
I
C
V
AI
R
S
E
AADA
GI
A
Q
AI
-
M
QQL
EE
A
L
K
Q
LAQG
A
G
--
S
S
Q
AL
T
QVRR
WD
SA
C
Q
KL
P
D
A
S
LALISV
A
G
E
YAA
E
L
A
N
QAL
DRN
LNVMMFSDNV
T
LEDE
IQ
LKT
R
AREKGLLVMGPDCGT
SM
I
A
G
T
PL
A
FANV
M
P
E
GNIGVIGASGTG
I
QEL
CS
Q
I
ALA
G
E
GI
TH
AIG
L
GGRDLS
R
E
V
GGIS
A
L
T
AL
E
ML
SA
D
E
K
S
EV
L
A
FV
SKPPA
E
AV
RL
KI
VNAM
KA
T
GKP
T
VA
L
FLG
YT
P
AVARDE
NV
W
FA
SSLD
EAA
RL
A
C
L
L
---
------------SRV
T
ARR
NA
IA
--
PVSSGF
I
C
GL
Y
T
GGTL
A
A
EA
AG
LL
AGHL
G
VE
A
-
--
---
D
DTHH
H
GM
M
LD
A
DG
H
Q
I
I
D
L
GDD
FY
T
V
G
R
PHPMIDP
A
LRN
Q
LI
A
D
L
GA
K
P
Q
V
L
VLL
L
D
V
V
I
GFGA
TA
DPA
A
SLV
S
A
WQ
KA
C
A
-
A
RS
DN
Q
PL
YA
IA
T
V
T
GTE
R
DPQ
C
RSQQI
AT
L
E
DAG
IA
V
V
SS
LPE
A
T
LLAAALI
fig|481805.6.peg.3312
Escherichia coli ATCC 8739 (6-493/555)
IK
K
G
C
F
QDSVSLM
I
IS
R
K
L
S
ES
E
N
VD
DV
SV
M
MGTP
A
NK
AL
L
DTT
G
F
WHDDFN
NA
T
PND
I
C
V
AI
R
S
E
AADA
GI
A
Q
AI
-
M
QQL
EE
A
L
K
Q
LAQG
A
G
--
S
S
Q
AL
T
QVRR
WD
SA
C
Q
KL
P
D
A
S
LALISV
A
G
E
YAA
E
L
A
N
QAL
DRN
LNVMMFSDNV
T
LEDE
IQ
LKT
R
AREKGLLVMGPDCGT
SM
I
A
G
T
PL
A
FANV
M
P
E
GNIGVIGASGTG
I
QEL
CS
Q
I
ALA
G
E
GI
TH
AIG
L
GGRDLS
R
E
V
GGIS
A
L
T
AL
E
ML
SA
D
E
K
S
EV
L
A
FV
SKPPA
E
AV
RL
KI
VNAM
KA
T
GKP
T
VA
L
FLG
YT
P
AVARDE
NV
W
FA
SSLD
EAA
RL
A
C
L
L
---
------------SRV
T
ARR
NA
IA
--
PVSSGF
I
C
GL
Y
T
GGTL
A
A
EA
AG
LL
AGHL
G
VE
A
-
--
---
D
DTHH
H
GM
M
LD
A
DG
H
Q
I
I
D
L
GDD
FY
T
V
G
R
PHPMIDP
A
LRN
Q
LI
A
D
L
GA
K
P
Q
V
L
VLL
L
D
V
V
I
GFGA
TA
DPA
A
SLV
S
A
WQ
KA
C
A
-
A
RS
DN
Q
PL
YA
IA
T
V
T
GTE
R
DPQ
C
RSQQI
AT
L
E
DAG
IA
V
V
SS
LPE
A
T
LLAAALI
Consen1
Primary consensus
MsVKivik
n
yqDSVSLM
IS
k
skl
gvdqasV
MgTp
Nk
L
Gl
nA
pnDl
iai
ge
neal
-
qql
ak
q
SG
s
q
t
----
sA
q
PeanLAlISV
G
yAA
eA
qAL
lNVMmFSDNVsledE
lKtlArEkgllvMGPDCGTaiing
pL
FaNvv
rGnIGviGASGTG
QEl
rI
G
GisqaiGtGGrDLSeeiGGismL
Al
mL
D
ktevialiSKPPapaVarkilerakAcgKPvVa
FLG
p
nv
fA
eAA
Av
L
---
t
na
rl
IrGlf
GGTlc
Ea
ll
G
a
sn
d
l
i
s
Ht
lD
GDDdfT
GkPHPMIDPtlRn
rl
de
dp
vaVll
D
VlGfGa
dPa
slv
a
ka
a
-
a
dn
pL
iA
V
GTe
Dpq
rsQQi
L
dAGvivaSS
a
LlAaalICKGEEA
Consen2
Secondary consensus
k
ykvf
g
ff
nes
ni
dvf
a
e
l
f
q
ng
i
vvv
sk
giqq
e
eer
l
d
e
sqvrr
m
dss
v
f
l
k
m
l
t
gq
i
qr
h
rqrim
smvaa
a
g
am
e
a
iv
v
q
vthll
l
h
rkv
lma
i
a
srilvfv
sei
rltvvnam
tr
t
v
e
g
a
s
c
lnd
p
dv
--
c
vy
fa
t
a
v
--
a
h
m
a
q
i
fy
r
an
i
li
l
ks
tr
v
i
y
s
t
v
et
-
l
hii
g
e
l
d
tp
le
s
n
ia
v
t
w
ref
Consensus 1
(when a gap)
Conservative difference
Consensus 2
(when a gap)
Nonconservative diff.
Other character