fig|1040638.4.peg.5411
Escherichia coli O104:H4 str. LB226692
MK
L
R
KTPVQGQGFVRPENQN
L
Q
N
F
GE
IIPVI
S
G
V
IGGRETNIVS
GR
ALHKALGVG
RV
F
R
S
WI
KG
RI
E
EY
G
FT
E
G
V
DY
E
V
VE
Y
L
S
RPD
P
VS
A
KS
RQQ
-----
T
A
L-------
-
---
E
Y
IIT
V
N
MAKELAM
V
ERTEQGRA
V
RQYFI
K
CEEELHK
V
AP
V
R
S
AALRRELKARITVAS
Y
FKPMCAALE
D
YRAE
L
GK
N
T
L
QHHYTTE
A
NMLARIVLGGMTAKQWAQ
V
NGI
T
GEPRDHMS
TL
QLEHLSYLEQSNITLIELG
Q
D
Y
H
QRKAELIRLSQRWLARRMEENSHV
fig|585055.6.peg.273
Escherichia coli 55989
MK
L
R
KTPVQGQGFVRPENQN
L
Q
N
F
GE
IIPVI
S
G
V
IGGRETNIVS
GR
ALHKALGVG
RV
F
R
S
WI
KG
RI
E
EY
G
FT
E
G
V
DY
E
V
VE
Y
L
S
RPD
P
VS
A
KS
RQQ
-----
T
A
L-------
-
---
E
Y
IIT
V
N
MAKELAM
V
ERTEQGRA
V
RQYFI
K
CEEELHK
V
AP
V
R
S
AALRRELKARITVAS
Y
FKPMCAALE
D
YRAE
L
GK
N
T
L
QHHYTTE
A
NMLARIVLGGMTAKQWAQ
V
NGI
T
GEPRDHMS
TL
QLEHLSYLEQSNITLIELG
Q
D
Y
H
QRKAELIRLSQRWLARRMEENSHV
fig|585055.8.peg.274
Escherichia coli 55989
MK
L
R
KTPVQGQGFVRPENQN
L
Q
N
F
GE
IIPVI
S
G
V
IGGRETNIVS
GR
ALHKALGVG
RV
F
R
S
WI
KG
RI
E
EY
G
FT
E
G
V
DY
E
V
VE
Y
L
S
RPD
P
VS
A
KS
RQQ
-----
T
A
L-------
-
---
E
Y
IIT
V
N
MAKELAM
V
ERTEQGRA
V
RQYFI
K
CEEELHK
V
AP
V
R
S
AALRRELKARITVAS
Y
FKPMCAALE
D
YRAE
L
GK
N
T
L
QHHYTTE
A
NMLARIVLGGMTAKQWAQ
V
NGI
T
GEPRDHMS
TL
QLEHLSYLEQSNITLIELG
Q
D
Y
H
QRKAELIRLSQRWLARRMEENSHV
fig|525281.3.peg.3102
Escherichia coli 83972
MK
F
PKTPVQGQGFVRPENQN
L
Q
N
F
GE
IIPVI
S
G
V
IGGRETNIVSA
R
ALHKALGVG
RV
F
R
S
WI
KG
RI
E
EY
G
FT
E
G
V
DY
E
V
VE
Y
L
S
RPD
P
VS
A
KS
RQQ
-----
T
A
L-------
-
---
E
Y
IIT
V
N
MAKELAM
V
E
H
TEQGRA
V
RQYFI
K
CEEELHK
V
AP
V
R
S
AALRRELKARITVAS
Y
FKPMCAALE
A
YRAE
L
GK
N
T
F
QHHYTTE
A
NMLARIVLGGMTAKQWAQ
A
NGI
T
GEPRDHMS
TL
QLEHLSYLEQSNITLIELG
Q
D
Y
H
QRKAELIRLSQRWLARRMEENSHV
fig|655817.3.peg.4269
Escherichia coli ABU 83972
MK
F
PKTPVQGQGFVRPENQN
L
Q
N
F
GE
IIPVI
S
G
V
IGGRETNIVSA
R
ALHKALGVG
RV
F
R
S
WI
KG
RI
E
EY
G
FT
E
G
V
DY
E
V
VE
Y
L
S
RPD
P
VS
A
KS
RQQ
-----
T
A
L-------
-
---
E
Y
IIT
V
N
MAKELAM
V
E
H
TEQGRA
V
RQYFI
K
CEEELHK
V
AP
V
R
S
AALRRELKARITVAS
Y
FKPMCAALE
A
YRAE
L
GK
N
T
F
QHHYTTE
A
NMLARIVLGGMTAKQWAQ
A
NGI
T
GEPRDHMS
TL
QLEHLSYLEQSNITLIELG
Q
D
Y
H
QRKAELIRLSQRWLARRMEENSHV
fig|6666666.5357.peg.3041
Escherichia coli TY-2482
MK
L
R
KTPVQGQGFVRPENQN
L
Q
N
F
GE
IIPVI
S
G
V
IGGRETNIVS
GR
ALHKALGVG
RV
F
R
S
WI
KG
RI
E
EY
G
FT
E
G
V
DY
E
V
VE
Y
L
S
RPD
P
VS
A
KS
RQQ
-----
T
A
L-------
-
---
E
Y
IIT
V
N
XX
KELAM
XXXX
E
X
GR
XXXX
YFI
X
C
X
EELHK
V
AP
V
R
S
AALRRELKARITVAS
Y
FKPMCAALE
D
YRAE
L
GK
N
T
L
QHHYTTE
A
NMLARIVLGGMTAKQWAQ
V
NGI
T
GEPRDHMS
TL
QLEHLSYLEQSNITLIELG
Q
D
Y
H
QRKAELIRLSQRWLARRMEENSHV
fig|749548.3.peg.4089
Escherichia coli MS 196-1 (1-273/274)
MK
L
R
KTPVQGQGFVRPENQN
L
Q
N
F
GE
IIPVI
S
G
V
IGGRE
AA
V
VSAKALHKALGVGKDF
S
TWITDRISEYDFT
I
G
Y
DYSVHK
T
IS
---
P
NL
GKS
PNG
-----
E
A
YSKIKHSG
R
PGK
DYLLSVGMAKELAMIERTEQGRA
V
RQYFI
K
CEEELHK
V
AP
V
R
S
AALRRELKARITVAS
Y
FKPMCAALE
A
YRAE
L
GK
N
T
L
QHHYTTE
A
NMLARIVLGGMTAKQWAQ
A
NGI
T
GEPRDHMS
TL
QLEHLSYLEQSNITLIELG
Q
D
Y
H
QRKAELIRLSQRWLARRME
V
S
SH
fig|562.373.peg.1562
Escherichia coli 1125A (1-281/282)
MK
R
P
NM
PVQGQGFV
QS
E
ELS
Q
Q
Y
FAAIIPV
S
PG
I
IGG
Y
ET
G
IVSA
R
ALHKALGVG
R
DF
T
TWI
KG
RI
E
EY
G
F
K
K
G
V
D
FE
V
VE
N
LY
FDS
P
KR
G
SQ
SVN
IEQFD
S
G
WTTKRGGD
R
RSE
DYL
I
S
TN
MAKELAM
V
ERTEQGRAIRQYFI
K
CEEELHK
A
APERAAALRRELKAR
V
TVAS
F
FKPMCAALE
L
YRAE
L
GK
E
T
H
QHHYTTESNMLARIVLGGMTAKQWAQ
A
NGI
K
G
K
PRD
S
MS
VM
QLEHLSYL
D
QSNITLIELGM
T
Y
Q
QRKAELIRLSQRWLARRM
G
E
HE
H
fig|478007.5.peg.1414
Escherichia coli O157:H7 str. EC508 (1-281/282)
MK
R
P
NM
PVQGQGFV
QS
E
ELS
Q
Q
Y
FAAIIPV
S
PG
I
IGG
Y
ET
G
IVSA
R
ALHKALGVG
R
DF
T
TWI
KG
RI
E
EY
G
F
K
K
G
V
D
FE
V
VE
N
LY
FDS
P
KR
G
SQ
SVN
IEQFD
S
G
WTTKRGGD
R
RSE
DYL
I
S
TN
MAKELAM
V
ERTEQGRAIRQYFI
K
CEEELHK
A
APERAAALRRELKAR
V
TVAS
F
FKPMCAALE
L
YRAE
L
GK
E
T
H
QHHYTTESNMLARIVLGGMTAKQWAQ
A
NGI
K
G
K
PRD
S
MS
VM
QLEHLSYL
D
QSNITLIELGM
T
Y
Q
QRKAELIRLSQRWLARRM
G
E
HE
H
fig|585395.4.peg.4747
Escherichia coli O103:H2 str. 12009 (1-281/282)
MK
R
P
NM
PVQGQGFV
QS
E
ELS
Q
Q
Y
FAAIIPV
S
PG
I
IGG
Y
ET
G
IVSA
R
ALHKALGVG
R
DF
T
TWI
KG
RI
E
EY
G
F
K
K
G
V
D
FE
V
VE
N
LY
FDS
P
KR
G
SQ
SVN
IEQFD
S
G
WTTKRGGD
R
RSE
DYL
I
S
TN
MAKELAM
V
ERTEQGRAIRQYFI
K
CEEELHK
A
APERAAALRRELKAR
V
TVAS
F
FKPMCAA
R
E
L
YRAE
L
GK
E
T
H
QHHYTTESNMLARIVLGGMTAKQWAQ
A
NGI
K
G
K
PRD
S
MS
VM
QLEHLSYL
D
QSNITLIELGM
T
Y
Q
QRKAELIRLSQRWLARRM
G
E
HE
H
fig|478006.5.peg.356
Escherichia coli O157:H7 str. EC4501 (1-281/282)
MK
R
P
NM
PVQGQGFV
QS
E
ELS
Q
Q
Y
FAAIIPV
S
PG
I
IGG
Y
ET
G
IVSA
R
ALHKALGVG
R
DF
T
TWI
KG
RI
E
EY
G
F
K
K
G
V
D
FE
V
VE
N
LY
FDS
P
KR
G
SQ
SVN
IEQFD
S
G
WTTKRGGD
R
RSE
DYL
I
S
TN
MAKELAM
V
ERTEQGRAIRQYFI
K
CEEELHK
A
APERAAALRRELKAR
V
TVAS
F
FKPMCAA
R
E
L
YRAE
L
GK
E
T
H
QHHYTTESNMLARIVLGGMTAKQWAQ
A
NGI
K
G
K
PRD
S
MS
VM
QLEHLSYL
D
QSNITLIELGM
T
Y
Q
QRKAELIRLSQRWLARRM
G
E
HE
H
fig|502346.5.peg.2104
Escherichia coli O157:H7 str. TW14588 (1-281/282)
MK
R
P
NM
PVQGQGFV
QS
E
ELS
Q
Q
Y
FAAIIPV
S
PG
I
IGG
Y
ET
G
IVSA
R
ALHKALGVG
R
DF
T
TWI
KG
RI
E
EY
G
F
K
K
G
V
D
FE
V
VE
N
LY
FDS
P
KR
G
SQ
SVN
IEQFD
S
G
WTTKRGGD
R
RSE
DYL
I
S
TN
MAKELAM
V
ERTEQGRAIRQYFI
K
CEEELHK
A
APERAAALRRELKAR
V
TVAS
F
FKPMCAA
R
E
L
YRAE
L
GK
E
T
H
QHHYTTESNMLARIVLGGMTAKQWAQ
A
NGI
K
G
K
PRD
S
MS
VM
QLEHLSYL
D
QSNITLIELGM
T
Y
Q
QRKAELIRLSQRWLARRM
G
E
HE
H
fig|670897.3.peg.3682
Escherichia coli 2362-75 (24-273/277)
N
G
N
E
FAAI
V
PVIPG
H
IGGRETNIVSAKALHKALGVGKDF
S
TWITDRISEYDFT
I
GHDYSVHK
T
IS
---
P
NL
GKS
PNG
-----
AA
YSKIKHSG
R
PGK
DYLLSVGMAKELAMIER
ND
QGRAIR
R
YFIQCEEEL
QR
T
V
PE
I
AA
RY
RR
Q
LKARI
SA
A
N
N
FKPMC
D
AL
N
M
A
RAE
M
GK
M
T
Q
QHHYT
N
ESNM
IS
RIVLGG
L
TAKQWA
R
I
NG
Y
S
GEPRDHM
N
AE
QLEHLSYLE
ST
NITLI
DM
GM
E
Y
E
QRK
G
EL
T
RLSQRWLA
K
R
L
E
fig|216592.1.peg.934
Escherichia coli 042 (24-273/277)
N
G
N
E
FAAI
V
PVIPG
H
IGGRETNIVSAKALHKALGVGKDF
S
TWITDRISEYDFT
I
GHDYSVHK
T
IS
---
P
NL
GKS
PNG
-----
AA
YSKIKQSG
R
PGK
DYLLSVGMAKELAMIER
ND
QGRAIR
R
YFIQCEEEL
QR
S
V
PE
I
AA
RY
RR
Q
LKARI
SA
A
N
N
FKPMC
D
AL
N
M
A
RAE
Q
GK
T
T
Q
QHHYT
N
ESNM
IS
RIVLGG
L
TAKQWA
R
I
NG
Y
S
GEPRDHM
N
AE
QLEHLSYLE
ST
NITLI
DM
GM
E
Y
E
QRK
G
EL
T
RLSQRWLA
K
R
L
E
fig|216592.3.peg.4108
Escherichia coli 042 (24-273/277)
N
G
N
E
FAAI
V
PVIPG
H
IGGRETNIVSAKALHKALGVGKDF
S
TWITDRISEYDFT
I
GHDYSVHK
T
IS
---
P
NL
GKS
PNG
-----
AA
YSKIKQSG
R
PGK
DYLLSVGMAKELAMIER
ND
QGRAIR
R
YFIQCEEEL
QR
S
V
PE
I
AA
RY
RR
Q
LKARI
SA
A
N
N
FKPMC
D
AL
N
M
A
RAE
Q
GK
T
T
Q
QHHYT
N
ESNM
IS
RIVLGG
L
TAKQWA
R
I
NG
Y
S
GEPRDHM
N
AE
QLEHLSYLE
ST
NITLI
DM
GM
E
Y
E
QRK
G
EL
T
RLSQRWLA
K
R
L
E
fig|679205.4.peg.3920
Escherichia coli MS 124-1 (24-273/277)
N
G
N
E
FAAI
V
PVIPG
H
IGGRETNIVSAKALHKALGVGKDF
S
TWITDRISEYDFT
I
GHDYSVHK
T
IS
---
P
NL
GKS
PNG
-----
AA
YSKIKQSG
R
PGK
DYLLSVGMAKELAMIER
ND
QGRAIR
R
YFIQCEEEL
QR
S
V
PE
I
AA
RY
RR
Q
LKARI
SA
A
N
N
FKPMC
D
AL
N
M
A
RAE
Q
GK
T
T
Q
QHHYT
N
ESNM
IS
RIVLGG
L
TAKQWA
R
I
NG
Y
S
GEPRDHM
N
AE
QLEHLSYLE
ST
NITLI
DM
GM
E
Y
E
QRK
G
EL
T
RLSQRWLA
K
R
L
E
fig|749545.3.peg.1552
Escherichia coli MS 182-1 (24-273/277)
N
G
N
E
FAAI
V
PVIPG
H
IGGRETNIVSAKALHKALGVGKDF
S
TWITDRISEYDFT
I
GHDYSVHK
T
IS
---
P
NL
GKS
PNG
-----
AA
YSKIKQSG
R
PGK
DYLLSVGMAKELAMIER
ND
QGRAIR
R
YFIQCEEEL
QR
S
V
PE
I
AA
RY
RR
Q
LKARI
SA
A
N
N
FKPMC
D
AL
N
M
A
RAE
Q
GK
T
T
Q
QHHYT
N
ESNM
IS
RIVLGG
L
TAKQWA
R
I
NG
Y
S
GEPRDHM
N
AE
QLEHLSYLE
ST
NITLI
DM
GM
E
Y
E
QRK
G
EL
T
RLSQRWLA
K
R
L
E
fig|749533.3.peg.97
Escherichia coli MS 84-1 (24-273/277)
N
G
N
E
FAAI
V
PVIPG
H
IGGRETNIVSAKALHKALGVGKDF
S
TWITDRISEYDFT
I
GHDYSVHK
T
IS
---
P
NL
GKS
PNG
-----
AA
YSKIKQSG
R
PGK
DYLLSVGMAKELAMIER
ND
QGRAIR
R
YFIQCEEEL
QR
S
V
PE
I
AA
RY
RR
Q
LKARI
SA
A
N
N
FKPMC
D
AL
N
M
A
RAE
Q
GK
T
T
Q
QHHYT
N
ESNM
IS
RIVLGG
L
TAKQWA
R
I
NG
Y
S
GEPRDHM
N
AE
QLEHLSYLE
ST
NITLI
DM
GM
E
Y
E
QRK
G
EL
T
RLSQRWLA
K
R
L
E
fig|525281.3.peg.2641
Escherichia coli 83972 (24-273/277)
N
G
N
E
FAAI
V
PVIPG
H
IGGRETNIVSAKALHKALGVGKDF
S
TWITDRISEYDFT
I
GHDYSVHK
T
IS
---
P
NL
GKS
PNG
-----
AA
YSKIKHSG
R
PGK
DYLLSVGMAKELAMIER
ND
QGRAIR
R
YFIQCEEEL
QR
S
V
PE
I
AA
RY
RR
Q
LKAR
L
SA
A
N
N
FKPMC
D
AL
N
M
A
RAE
M
GK
T
T
Q
QHHYT
N
ESNM
IS
RIVLGG
L
TAKQWA
R
I
NG
Y
S
GEPRDHM
N
AE
QLEHLSYLE
ST
NITLI
DM
GM
E
Y
E
QRK
G
EL
T
RLSQRWLA
K
R
L
E
fig|655817.3.peg.371
Escherichia coli ABU 83972 (24-273/277)
N
G
N
E
FAAI
V
PVIPG
H
IGGRETNIVSAKALHKALGVGKDF
S
TWITDRISEYDFT
I
GHDYSVHK
T
IS
---
P
NL
GKS
PNG
-----
AA
YSKIKHSG
R
PGK
DYLLSVGMAKELAMIER
ND
QGRAIR
R
YFIQCEEEL
QR
S
V
PE
I
AA
RY
RR
Q
LKAR
L
SA
A
N
N
FKPMC
D
AL
N
M
A
RAE
M
GK
T
T
Q
QHHYT
N
ESNM
IS
RIVLGG
L
TAKQWA
R
I
NG
Y
S
GEPRDHM
N
AE
QLEHLSYLE
ST
NITLI
DM
GM
E
Y
E
QRK
G
EL
T
RLSQRWLA
K
R
L
E
fig|316401.4.peg.364
Escherichia coli ETEC H10407 (24-273/277)
N
G
N
E
FAAI
V
PVIPG
H
IGGRETNIVSAKALHKALGVGKDF
S
TWITDRISEYDFT
I
GHDYSVHK
T
IS
---
P
NL
GKS
PNG
-----
AA
YSKIKHSG
R
PGK
DYLLSVGMAKELAMIER
ND
QGRAIR
R
YFIQCEEEL
QR
S
V
PE
I
AA
RY
RR
Q
LKARI
SA
A
N
N
FKPMC
D
AL
N
M
A
RAE
Q
GK
T
T
Q
QHHYT
N
ESNM
IS
RIVLGG
L
TAKQWA
R
I
NG
Y
S
GEPRDHM
N
AE
QLEHLSYLE
ST
NITLI
DM
GM
E
Y
E
QRK
G
EL
T
RLSQRWLA
K
R
L
E
fig|749527.3.peg.3861
Escherichia coli MS 21-1 (24-273/277)
N
G
N
E
FAAI
V
PVIPG
H
IGGRETNIVSAKALHKALGVGKDF
S
TWITDRISEYDFT
I
GHDYSVHK
T
IS
---
P
NL
GKS
PNG
-----
AA
YSKIKHSG
R
PGK
DYLLSVGMAKELAMIER
ND
QGRAIR
R
YFIQCEEEL
QR
S
V
PE
I
AA
RY
RR
Q
LKARI
SA
A
N
N
FKPMC
D
AL
N
M
A
RAE
Q
GK
T
T
Q
QHHYT
N
ESNM
IS
RIVLGG
L
TAKQWA
R
I
NG
Y
S
GEPRDHM
N
AE
QLEHLSYLE
ST
NITLI
DM
GM
E
Y
E
QRK
G
EL
T
RLSQRWLA
K
R
L
E
fig|753642.3.peg.1379
Escherichia coli NC101 (24-273/277)
N
G
N
E
FAAI
V
PVIPG
H
IGGRE
A
NIVSAKALHKALGVGKDF
S
TWITDRISEYDFT
I
GHDYSVHK
T
IS
---
P
NL
GKS
PNG
-----
AA
YSKIKQSG
R
PGK
DYLLSVGMAKELAMIER
ND
QGRAIR
R
YFIQCEEEL
QR
S
V
PE
I
AA
RY
RR
Q
LKARI
SA
A
N
N
FKPMC
D
AL
N
M
A
RAE
Q
GK
T
T
Q
QHHYT
N
ESNM
IS
RIVLG
W
L
TAKQWA
R
I
NG
Y
S
GEPRDHM
N
AE
QLEHLSYLE
ST
NITLI
DM
GM
E
Y
E
QRK
G
EL
A
RLSQRWLA
K
R
L
E
Consen1
Primary consensus
MK
pktPVQGQGFVrpEnqn
q
FaaIiPVipG
IGGrETnIVSakALHKALGVGkdF
tWItdRIsEYdFt
GhDysVhk
is
P
gks
-----
aa
r
dYllsvgMAKELAMiErteQGRAiRqYFIqCEEELhk
aPeraAalRReLKARitvAs
FKPMCaAle
yRAE
GK
T
QHHYTtEsNMlaRIVLGGmTAKQWAq
NGi
GePRDhMs
QLEHLSYLeqsNITLIelGm
Y
QRKaELiRLSQRWLArRmeEnsHV
Consen2
Secondary consensus
rnm
qs
els
n
ge
v
ss
y
g
gr
rv
s
kg
e
g
k
v
fe
ve
ly
asq
ieqfd
g
-
e
iittn
v
hnd
v
r
k
qr
v
vis
ry
q
vsa
n
d
rn
a
n
a
is
l
r
y
k
s
n
dst
dm
q
g
t
k
lg
he
Consensus 1
(when a gap)
Conservative difference
Consensus 2
(when a gap)
Nonconservative diff.
Other character