fig|344610.3.peg.1602
Escherichia coli 53638 (12-487/487)
LAPL
V
V
MG
VM
F
LIP
V
P
D
G
M
PPQ
AW
H
YFAVF
V
A
M
IVG
M
ILEP
I
P
AT
AI
SF
IAVTI
CV
I
G
S
NY
LLF
DAKE
LA
D
P
A
F
NAQ
K
QA
L
K
W
G
L
A
GFSS
T
T
V
WLVF
G
AF
I
F
AL
GYE
V
S
GLGRRIAL
F
LVK
F
MG
K
RTL
T
LGYA
I
V
I
I
D
I
L
LAP
F
TPSNTAR
T
GG
T
V
F
P
V
I
K
NLPPL
FK
S
F
PND
P
S
A
RRIG
G
YLMWM
MV
I
S
T
SL
S
S
S
MF
V
T
GA
APN
V
L
G
L
EF
V
SK
I
A
G
I
--
QISW
L
Q
WFL
CF
LP
V
G
V
ILL
I
I
A
PWL
S
YVLY
K
PEI
T
HS
E
E
V
A
TWA
GD
EL
KT
MG
A
L
TR
RE
W
T
L
I
GL
V
L
L
S
L
G
LW
V
FG
SEV
--
I
N
AT
A
VG
LL
A
V
S
LML
A
--
L
H
V
V
P
WKDI
T
R
YN
S
AWNTL
V
N
LA
T
L
V
V
M
A
N
GLT
RS
GFI
D
WFA
GTMST
HL
E
G
F
SP
NA
----
TVI
VL
V
L
VFY
FA
H
Y
L
FAS
L
SA
H
T
A
T
MLPV
IL
A
V
G
KGI
P
---
G
V
P
M
EQL
C
I
L
L
VL
SIG
I
M
G
C
LTPYATGPG
V
IIYG
C
GY
VKSK
DYWRLGAIFGVI
Y
ISM
LL
L
VG
WP
IL
A
M
W
N
fig|585055.6.peg.616
Escherichia coli 55989 (12-487/487)
LAPL
V
V
MG
VM
F
LIP
V
P
D
G
M
PPQ
AW
H
YFAVF
V
A
M
IVG
M
ILEP
I
P
AT
AI
SF
IAVTI
CV
I
G
S
NY
LLF
DAKE
LA
D
P
A
F
NAQ
K
QA
L
K
W
G
L
A
GFSS
T
T
V
WLVF
G
AF
I
F
AL
GYE
V
S
GLGRRIAL
F
LVK
F
MG
K
RTL
T
LGYA
I
V
I
I
D
I
L
LAP
F
TPSNTAR
T
GG
T
V
F
P
V
I
K
NLPPL
FK
S
F
PND
P
S
A
RRIG
G
YLMWM
MV
I
S
T
SL
S
S
S
MF
V
T
GA
APN
V
L
G
L
EF
V
SK
I
A
G
I
--
QISW
L
Q
WFL
CF
LP
V
G
V
ILL
I
I
A
PWL
S
YVLY
K
PEI
T
HS
E
E
V
A
TWA
GD
EL
KT
MG
A
L
TR
RE
W
T
L
I
GL
V
L
L
S
L
G
LW
V
FG
SEV
--
I
N
AT
A
VG
LL
A
V
S
LML
A
--
L
H
V
V
P
WKDI
T
R
YN
S
AWNTL
V
N
LA
T
L
V
V
M
A
N
GLT
RS
GFI
D
WFA
GTMST
HL
E
G
F
SP
NA
----
TVI
VL
V
L
VFY
FA
H
Y
L
FAS
L
SA
H
T
A
T
MLPV
IL
A
V
G
KGI
P
---
G
V
P
M
EQL
C
I
L
L
VL
SIG
I
M
G
C
LTPYATGPG
V
IIYG
C
GY
VKSK
DYWRLGAIFGVI
Y
ISM
LL
L
VG
WP
IL
A
M
W
N
fig|585055.8.peg.617
Escherichia coli 55989 (12-487/487)
LAPL
V
V
MG
VM
F
LIP
V
P
D
G
M
PPQ
AW
H
YFAVF
V
A
M
IVG
M
ILEP
I
P
AT
AI
SF
IAVTI
CV
I
G
S
NY
LLF
DAKE
LA
D
P
A
F
NAQ
K
QA
L
K
W
G
L
A
GFSS
T
T
V
WLVF
G
AF
I
F
AL
GYE
V
S
GLGRRIAL
F
LVK
F
MG
K
RTL
T
LGYA
I
V
I
I
D
I
L
LAP
F
TPSNTAR
T
GG
T
V
F
P
V
I
K
NLPPL
FK
S
F
PND
P
S
A
RRIG
G
YLMWM
MV
I
S
T
SL
S
S
S
MF
V
T
GA
APN
V
L
G
L
EF
V
SK
I
A
G
I
--
QISW
L
Q
WFL
CF
LP
V
G
V
ILL
I
I
A
PWL
S
YVLY
K
PEI
T
HS
E
E
V
A
TWA
GD
EL
KT
MG
A
L
TR
RE
W
T
L
I
GL
V
L
L
S
L
G
LW
V
FG
SEV
--
I
N
AT
A
VG
LL
A
V
S
LML
A
--
L
H
V
V
P
WKDI
T
R
YN
S
AWNTL
V
N
LA
T
L
V
V
M
A
N
GLT
RS
GFI
D
WFA
GTMST
HL
E
G
F
SP
NA
----
TVI
VL
V
L
VFY
FA
H
Y
L
FAS
L
SA
H
T
A
T
MLPV
IL
A
V
G
KGI
P
---
G
V
P
M
EQL
C
I
L
L
VL
SIG
I
M
G
C
LTPYATGPG
V
IIYG
C
GY
VKSK
DYWRLGAIFGVI
Y
ISM
LL
L
VG
WP
IL
A
M
W
N
fig|481805.3.peg.3252
Escherichia coli ATCC 8739 (12-487/487)
LAPL
V
V
MG
VM
F
LIP
V
P
D
G
M
PPQ
AW
H
YFAVF
V
A
M
IVG
M
ILEP
I
P
AT
AI
SF
IAVTI
CV
I
G
S
NY
LLF
DAKE
LA
D
P
A
F
NAQ
K
QA
L
K
W
G
L
A
GFSS
T
T
V
WLVF
G
AF
I
F
AL
GYE
V
S
GLGRRIAL
F
LVK
F
MG
K
RTL
T
LGYA
I
V
I
I
D
I
L
LAP
F
TPSNTAR
T
GG
T
V
F
P
V
I
K
NLPPL
FK
S
F
PND
P
S
A
RRIG
G
YLMWM
MV
I
S
T
SL
S
S
S
MF
V
T
GA
APN
V
L
G
L
EF
V
SK
I
A
G
I
--
QISW
L
Q
WFL
CF
LP
V
G
V
ILL
I
I
A
PWL
S
YVLY
K
PEI
T
HS
E
E
V
A
TWA
GD
EL
KT
MG
A
L
TR
RE
W
T
L
I
GL
V
L
L
S
L
G
LW
V
FG
SEV
--
I
N
AT
A
VG
LL
A
V
S
LML
A
--
L
H
V
V
P
WKDI
T
R
YN
S
AWNTL
V
N
LA
T
L
V
V
M
A
N
GLT
RS
GFI
D
WFA
GTMST
HL
E
G
F
SP
NA
----
TVI
VL
V
L
VFY
FA
H
Y
L
FAS
L
SA
H
T
A
T
MLPV
IL
A
V
G
KGI
P
---
G
V
P
M
EQL
C
I
L
L
VL
SIG
I
M
G
C
LTPYATGPG
V
IIYG
C
GY
VKSK
DYWRLGAIFGVI
Y
ISM
LL
L
VG
WP
IL
A
M
W
N
fig|344601.3.peg.2257
Escherichia coli B171 (12-487/487)
LAPL
V
V
MG
VM
F
LIP
V
P
D
G
M
PPQ
AW
H
YFAVF
V
A
M
IVG
M
ILEP
I
P
AT
AI
SF
IAVTI
CV
I
G
S
NY
LLF
DAKE
LA
D
P
A
F
NAQ
K
QA
L
K
W
G
L
A
GFSS
T
T
V
WLVF
G
AF
I
F
AL
GYE
V
S
GLGRRIAL
F
LVK
F
MG
K
RTL
T
LGYA
I
V
I
I
D
I
L
LAP
F
TPSNTAR
T
GG
T
V
F
P
V
I
K
NLPPL
FK
S
F
PND
P
S
A
RRIG
G
YLMWM
MV
I
S
T
SL
S
S
S
MF
V
T
GA
APN
V
L
G
L
EF
V
SK
I
A
G
I
--
QISW
L
Q
WFL
CF
LP
V
G
V
ILL
I
I
A
PWL
S
YVLY
K
PEI
T
HS
E
E
V
A
TWA
GD
EL
KT
MG
A
L
TR
RE
W
T
L
I
GL
V
L
L
S
L
G
LW
V
FG
SEV
--
I
N
AT
A
VG
LL
A
V
S
LML
A
--
L
H
V
V
P
WKDI
T
R
YN
S
AWNTL
V
N
LA
T
L
V
V
M
A
N
GLT
RS
GFI
D
WFA
GTMST
HL
E
G
F
SP
NA
----
TVI
VL
V
L
VFY
FA
H
Y
L
FAS
L
SA
H
T
A
T
MLPV
IL
A
V
G
KGI
P
---
G
V
P
M
EQL
C
I
L
L
VL
SIG
I
M
G
C
LTPYATGPG
V
IIYG
C
GY
VKSK
DYWRLGAIFGVI
Y
ISM
LL
L
VG
WP
IL
A
M
W
N
fig|344601.5.peg.2359
Escherichia coli B171 (12-487/487)
LAPL
V
V
MG
VM
F
LIP
V
P
D
G
M
PPQ
AW
H
YFAVF
V
A
M
IVG
M
ILEP
I
P
AT
AI
SF
IAVTI
CV
I
G
S
NY
LLF
DAKE
LA
D
P
A
F
NAQ
K
QA
L
K
W
G
L
A
GFSS
T
T
V
WLVF
G
AF
I
F
AL
GYE
V
S
GLGRRIAL
F
LVK
F
MG
K
RTL
T
LGYA
I
V
I
I
D
I
L
LAP
F
TPSNTAR
T
GG
T
V
F
P
V
I
K
NLPPL
FK
S
F
PND
P
S
A
RRIG
G
YLMWM
MV
I
S
T
SL
S
S
S
MF
V
T
GA
APN
V
L
G
L
EF
V
SK
I
A
G
I
--
QISW
L
Q
WFL
CF
LP
V
G
V
ILL
I
I
A
PWL
S
YVLY
K
PEI
T
HS
E
E
V
A
TWA
GD
EL
KT
MG
A
L
TR
RE
W
T
L
I
GL
V
L
L
S
L
G
LW
V
FG
SEV
--
I
N
AT
A
VG
LL
A
V
S
LML
A
--
L
H
V
V
P
WKDI
T
R
YN
S
AWNTL
V
N
LA
T
L
V
V
M
A
N
GLT
RS
GFI
D
WFA
GTMST
HL
E
G
F
SP
NA
----
TVI
VL
V
L
VFY
FA
H
Y
L
FAS
L
SA
H
T
A
T
MLPV
IL
A
V
G
KGI
P
---
G
V
P
M
EQL
C
I
L
L
VL
SIG
I
M
G
C
LTPYATGPG
V
IIYG
C
GY
VKSK
DYWRLGAIFGVI
Y
ISM
LL
L
VG
WP
IL
A
M
W
N
fig|340184.3.peg.2426
Escherichia coli B7A (12-487/487)
LAPL
V
V
MG
VM
F
LIP
V
P
D
G
M
PPQ
AW
H
YFAVF
V
A
M
IVG
M
ILEP
I
P
AT
AI
SF
IAVTI
CV
I
G
S
NY
LLF
DAKE
LA
D
P
A
F
NAQ
K
QA
L
K
W
G
L
A
GFSS
T
T
V
WLVF
G
AF
I
F
AL
GYE
V
S
GLGRRIAL
F
LVK
F
MG
K
RTL
T
LGYA
I
V
I
I
D
I
L
LAP
F
TPSNTAR
T
GG
T
V
F
P
V
I
K
NLPPL
FK
S
F
PND
P
S
A
RRIG
G
YLMWM
MV
I
S
T
SL
S
S
S
MF
V
T
GA
APN
V
L
G
L
EF
V
SK
I
A
G
I
--
QISW
L
Q
WFL
CF
LP
V
G
V
ILL
I
I
A
PWL
S
YVLY
K
PEI
T
HS
E
E
V
A
TWA
GD
EL
KT
MG
A
L
TR
RE
W
T
L
I
GL
V
L
L
S
L
G
LW
V
FG
SEV
--
I
N
AT
A
VG
LL
A
V
S
LML
A
--
L
H
V
V
P
WKDI
T
R
YN
S
AWNTL
V
N
LA
T
L
V
V
M
A
N
GLT
RS
GFI
D
WFA
GTMST
HL
E
G
F
SP
NA
----
TVI
VL
V
L
VFY
FA
H
Y
L
FAS
L
SA
H
T
A
T
MLPV
IL
A
V
G
KGI
P
---
G
V
P
M
EQL
C
I
L
L
VL
SIG
I
M
G
C
LTPYATGPG
V
IIYG
C
GY
VKSK
DYWRLGAIFGVI
Y
ISM
LL
L
VG
WP
IL
A
M
W
N
fig|340186.3.peg.2267
Escherichia coli E110019 (12-487/487)
LAPL
V
V
MG
VM
F
LIP
V
P
D
G
M
PPQ
AW
H
YFAVF
V
A
M
IVG
M
ILEP
I
P
AT
AI
SF
IAVTI
CV
I
G
S
NY
LLF
DAKE
LA
D
P
A
F
NAQ
K
QA
L
K
W
G
L
A
GFSS
T
T
V
WLVF
G
AF
I
F
AL
GYE
V
S
GLGRRIAL
F
LVK
F
MG
K
RTL
T
LGYA
I
V
I
I
D
I
L
LAP
F
TPSNTAR
T
GG
T
V
F
P
V
I
K
NLPPL
FK
S
F
PND
P
S
A
RRIG
G
YLMWM
MV
I
S
T
SL
S
S
S
MF
V
T
GA
APN
V
L
G
L
EF
V
SK
I
A
G
I
--
QISW
L
Q
WFL
CF
LP
V
G
V
ILL
I
I
A
PWL
S
YVLY
K
PEI
T
HS
E
E
V
A
TWA
GD
EL
KT
MG
A
L
TR
RE
W
T
L
I
GL
V
L
L
S
L
G
LW
V
FG
SEV
--
I
N
AT
A
VG
LL
A
V
S
LML
A
--
L
H
V
V
P
WKDI
T
R
YN
S
AWNTL
V
N
LA
T
L
V
V
M
A
N
GLT
RS
GFI
D
WFA
GTMST
HL
E
G
F
SP
NA
----
TVI
VL
V
L
VFY
FA
H
Y
L
FAS
L
SA
H
T
A
T
MLPV
IL
A
V
G
KGI
P
---
G
V
P
M
EQL
C
I
L
L
VL
SIG
I
M
G
C
LTPYATGPG
V
IIYG
C
GY
VKSK
DYWRLGAIFGVI
Y
ISM
LL
L
VG
WP
IL
A
M
W
N
fig|340186.5.peg.2340
Escherichia coli E110019 (12-487/487)
LAPL
V
V
MG
VM
F
LIP
V
P
D
G
M
PPQ
AW
H
YFAVF
V
A
M
IVG
M
ILEP
I
P
AT
AI
SF
IAVTI
CV
I
G
S
NY
LLF
DAKE
LA
D
P
A
F
NAQ
K
QA
L
K
W
G
L
A
GFSS
T
T
V
WLVF
G
AF
I
F
AL
GYE
V
S
GLGRRIAL
F
LVK
F
MG
K
RTL
T
LGYA
I
V
I
I
D
I
L
LAP
F
TPSNTAR
T
GG
T
V
F
P
V
I
K
NLPPL
FK
S
F
PND
P
S
A
RRIG
G
YLMWM
MV
I
S
T
SL
S
S
S
MF
V
T
GA
APN
V
L
G
L
EF
V
SK
I
A
G
I
--
QISW
L
Q
WFL
CF
LP
V
G
V
ILL
I
I
A
PWL
S
YVLY
K
PEI
T
HS
E
E
V
A
TWA
GD
EL
KT
MG
A
L
TR
RE
W
T
L
I
GL
V
L
L
S
L
G
LW
V
FG
SEV
--
I
N
AT
A
VG
LL
A
V
S
LML
A
--
L
H
V
V
P
WKDI
T
R
YN
S
AWNTL
V
N
LA
T
L
V
V
M
A
N
GLT
RS
GFI
D
WFA
GTMST
HL
E
G
F
SP
NA
----
TVI
VL
V
L
VFY
FA
H
Y
L
FAS
L
SA
H
T
A
T
MLPV
IL
A
V
G
KGI
P
---
G
V
P
M
EQL
C
I
L
L
VL
SIG
I
M
G
C
LTPYATGPG
V
IIYG
C
GY
VKSK
DYWRLGAIFGVI
Y
ISM
LL
L
VG
WP
IL
A
M
W
N
fig|340185.3.peg.1723
Escherichia coli E22 (12-487/487)
LAPL
V
V
MG
VM
F
LIP
V
P
D
G
M
PPQ
AW
H
YFAVF
V
A
M
IVG
M
ILEP
I
P
AT
AI
SF
IAVTI
CV
I
G
S
NY
LLF
DAKE
LA
D
P
A
F
NAQ
K
QA
L
K
W
G
L
A
GFSS
T
T
V
WLVF
G
AF
I
F
AL
GYE
V
S
GLGRRIAL
F
LVK
F
MG
K
RTL
T
LGYA
I
V
I
I
D
I
L
LAP
F
TPSNTAR
T
GG
T
V
F
P
V
I
K
NLPPL
FK
S
F
PND
P
S
A
RRIG
G
YLMWM
MV
I
S
T
SL
S
S
S
MF
V
T
GA
APN
V
L
G
L
EF
V
SK
I
A
G
I
--
QISW
L
Q
WFL
CF
LP
V
G
V
ILL
I
I
A
PWL
S
YVLY
K
PEI
T
HS
E
E
V
A
TWA
GD
EL
KT
MG
A
L
TR
RE
W
T
L
I
GL
V
L
L
S
L
G
LW
V
FG
SEV
--
I
N
AT
A
VG
LL
A
V
S
LML
A
--
L
H
V
V
P
WKDI
T
R
YN
S
AWNTL
V
N
LA
T
L
V
V
M
A
N
GLT
RS
GFI
D
WFA
GTMST
HL
E
G
F
SP
NA
----
TVI
VL
V
L
VFY
FA
H
Y
L
FAS
L
SA
H
T
A
T
MLPV
IL
A
V
G
KGI
P
---
G
V
P
M
EQL
C
I
L
L
VL
SIG
I
M
G
C
LTPYATGPG
V
IIYG
C
GY
VKSK
DYWRLGAIFGVI
Y
ISM
LL
L
VG
WP
IL
A
M
W
N
fig|340185.4.peg.1816
Escherichia coli E22 (12-487/487)
LAPL
V
V
MG
VM
F
LIP
V
P
D
G
M
PPQ
AW
H
YFAVF
V
A
M
IVG
M
ILEP
I
P
AT
AI
SF
IAVTI
CV
I
G
S
NY
LLF
DAKE
LA
D
P
A
F
NAQ
K
QA
L
K
W
G
L
A
GFSS
T
T
V
WLVF
G
AF
I
F
AL
GYE
V
S
GLGRRIAL
F
LVK
F
MG
K
RTL
T
LGYA
I
V
I
I
D
I
L
LAP
F
TPSNTAR
T
GG
T
V
F
P
V
I
K
NLPPL
FK
S
F
PND
P
S
A
RRIG
G
YLMWM
MV
I
S
T
SL
S
S
S
MF
V
T
GA
APN
V
L
G
L
EF
V
SK
I
A
G
I
--
QISW
L
Q
WFL
CF
LP
V
G
V
ILL
I
I
A
PWL
S
YVLY
K
PEI
T
HS
E
E
V
A
TWA
GD
EL
KT
MG
A
L
TR
RE
W
T
L
I
GL
V
L
L
S
L
G
LW
V
FG
SEV
--
I
N
AT
A
VG
LL
A
V
S
LML
A
--
L
H
V
V
P
WKDI
T
R
YN
S
AWNTL
V
N
LA
T
L
V
V
M
A
N
GLT
RS
GFI
D
WFA
GTMST
HL
E
G
F
SP
NA
----
TVI
VL
V
L
VFY
FA
H
Y
L
FAS
L
SA
H
T
A
T
MLPV
IL
A
V
G
KGI
P
---
G
V
P
M
EQL
C
I
L
L
VL
SIG
I
M
G
C
LTPYATGPG
V
IIYG
C
GY
VKSK
DYWRLGAIFGVI
Y
ISM
LL
L
VG
WP
IL
A
M
W
N
fig|331111.3.peg.3162
Escherichia coli E24377A (12-487/487)
LAPL
V
V
MG
VM
F
LIP
V
P
D
G
M
PPQ
AW
H
YFAVF
V
A
M
IVG
M
ILEP
I
P
AT
AI
SF
IAVTI
CV
I
G
S
NY
LLF
DAKE
LA
D
P
A
F
NAQ
K
QA
L
K
W
G
L
A
GFSS
T
T
V
WLVF
G
AF
I
F
AL
GYE
V
S
GLGRRIAL
F
LVK
F
MG
K
RTL
T
LGYA
I
V
I
I
D
I
L
LAP
F
TPSNTAR
T
GG
T
V
F
P
V
I
K
NLPPL
FK
S
F
PND
P
S
A
RRIG
G
YLMWM
MV
I
S
T
SL
S
S
S
MF
V
T
GA
APN
V
L
G
L
EF
V
SK
I
A
G
I
--
QISW
L
Q
WFL
CF
LP
V
G
V
ILL
I
I
A
PWL
S
YVLY
K
PEI
T
HS
E
E
V
A
TWA
GD
EL
KT
MG
A
L
TR
RE
W
T
L
I
GL
V
L
L
S
L
G
LW
V
FG
SEV
--
I
N
AT
A
VG
LL
A
V
S
LML
A
--
L
H
V
V
P
WKDI
T
R
YN
S
AWNTL
V
N
LA
T
L
V
V
M
A
N
GLT
RS
GFI
D
WFA
GTMST
HL
E
G
F
SP
NA
----
TVI
VL
V
L
VFY
FA
H
Y
L
FAS
L
SA
H
T
A
T
MLPV
IL
A
V
G
KGI
P
---
G
V
P
M
EQL
C
I
L
L
VL
SIG
I
M
G
C
LTPYATGPG
V
IIYG
C
GY
VKSK
DYWRLGAIFGVI
Y
ISM
LL
L
VG
WP
IL
A
M
W
N
fig|316401.4.peg.736
Escherichia coli ETEC H10407 (12-487/487)
LAPL
V
V
MG
VM
F
LIP
V
P
D
G
M
PPQ
AW
H
YFAVF
V
A
M
IVG
M
ILEP
I
P
AT
AI
SF
IAVTI
CV
I
G
S
NY
LLF
DAKE
LA
D
P
A
F
NAQ
K
QA
L
K
W
G
L
A
GFSS
T
T
V
WLVF
G
AF
I
F
AL
GYE
V
S
GLGRRIAL
F
LVK
F
MG
K
RTL
T
LGYA
I
V
I
I
D
I
L
LAP
F
TPSNTAR
T
GG
T
V
F
P
V
I
K
NLPPL
FK
S
F
PND
P
S
A
RRIG
G
YLMWM
MV
I
S
T
SL
S
S
S
MF
V
T
GA
APN
V
L
G
L
EF
V
SK
I
A
G
I
--
QISW
L
Q
WFL
CF
LP
V
G
V
ILL
I
I
A
PWL
S
YVLY
K
PEI
T
HS
E
E
V
A
TWA
GD
EL
KT
MG
A
L
TR
RE
W
T
L
I
GL
V
L
L
S
L
G
LW
V
FG
SEV
--
I
N
AT
A
VG
LL
A
V
S
LML
A
--
L
H
V
V
P
WKDI
T
R
YN
S
AWNTL
V
N
LA
T
L
V
V
M
A
N
GLT
RS
GFI
D
WFA
GTMST
HL
E
G
F
SP
NA
----
TVI
VL
V
L
VFY
FA
H
Y
L
FAS
L
SA
H
T
A
T
MLPV
IL
A
V
G
KGI
P
---
G
V
P
M
EQL
C
I
L
L
VL
SIG
I
M
G
C
LTPYATGPG
V
IIYG
C
GY
VKSK
DYWRLGAIFGVI
Y
ISM
LL
L
VG
WP
IL
A
M
W
N
fig|331112.3.peg.620
Escherichia coli HS (12-487/487)
LAPL
V
V
MG
VM
F
LIP
V
P
D
G
M
PPQ
AW
H
YFAVF
V
A
M
IVG
M
ILEP
I
P
AT
AI
SF
IAVTI
CV
I
G
S
NY
LLF
DAKE
LA
D
P
A
F
NAQ
K
QA
L
K
W
G
L
A
GFSS
T
T
V
WLVF
G
AF
I
F
AL
GYE
V
S
GLGRRIAL
F
LVK
F
MG
K
RTL
T
LGYA
I
V
I
I
D
I
L
LAP
F
TPSNTAR
T
GG
T
V
F
P
V
I
K
NLPPL
FK
S
F
PND
P
S
A
RRIG
G
YLMWM
MV
I
S
T
SL
S
S
S
MF
V
T
GA
APN
V
L
G
L
EF
V
SK
I
A
G
I
--
QISW
L
Q
WFL
CF
LP
V
G
V
ILL
I
I
A
PWL
S
YVLY
K
PEI
T
HS
E
E
V
A
TWA
GD
EL
KT
MG
A
L
TR
RE
W
T
L
I
GL
V
L
L
S
L
G
LW
V
FG
SEV
--
I
N
AT
A
VG
LL
A
V
S
LML
A
--
L
H
V
V
P
WKDI
T
R
YN
S
AWNTL
V
N
LA
T
L
V
V
M
A
N
GLT
RS
GFI
D
WFA
GTMST
HL
E
G
F
SP
NA
----
TVI
VL
V
L
VFY
FA
H
Y
L
FAS
L
SA
H
T
A
T
MLPV
IL
A
V
G
KGI
P
---
G
V
P
M
EQL
C
I
L
L
VL
SIG
I
M
G
C
LTPYATGPG
V
IIYG
C
GY
VKSK
DYWRLGAIFGVI
Y
ISM
LL
L
VG
WP
IL
A
M
W
N
fig|83333.1.peg.613
Escherichia coli K12 (12-487/487)
LAPL
V
V
MG
VM
F
LIP
V
P
D
G
M
PPQ
AW
H
YFAVF
V
A
M
IVG
M
ILEP
I
P
AT
AI
SF
IAVTI
CV
I
G
S
NY
LLF
DAKE
LA
D
P
A
F
NAQ
K
QA
L
K
W
G
L
A
GFSS
T
T
V
WLVF
G
AF
I
F
AL
GYE
V
S
GLGRRIAL
F
LVK
F
MG
K
RTL
T
LGYA
I
V
I
I
D
I
L
LAP
F
TPSNTAR
T
GG
T
V
F
P
V
I
K
NLPPL
FK
S
F
PND
P
S
A
RRIG
G
YLMWM
MV
I
S
T
SL
S
S
S
MF
V
T
GA
APN
V
L
G
L
EF
V
SK
I
A
G
I
--
QISW
L
Q
WFL
CF
LP
V
G
V
ILL
I
I
A
PWL
S
YVLY
K
PEI
T
HS
E
E
V
A
TWA
GD
EL
KT
MG
A
L
TR
RE
W
T
L
I
GL
V
L
L
S
L
G
LW
V
FG
SEV
--
I
N
AT
A
VG
LL
A
V
S
LML
A
--
L
H
V
V
P
WKDI
T
R
YN
S
AWNTL
V
N
LA
T
L
V
V
M
A
N
GLT
RS
GFI
D
WFA
GTMST
HL
E
G
F
SP
NA
----
TVI
VL
V
L
VFY
FA
H
Y
L
FAS
L
SA
H
T
A
T
MLPV
IL
A
V
G
KGI
P
---
G
V
P
M
EQL
C
I
L
L
VL
SIG
I
M
G
C
LTPYATGPG
V
IIYG
C
GY
VKSK
DYWRLGAIFGVI
Y
ISM
LL
L
VG
WP
IL
A
M
W
N
fig|656419.3.peg.891
Escherichia coli M718 (12-487/487)
LAPL
V
V
MG
VM
F
LIP
V
P
D
G
M
PPQ
AW
H
YFAVF
V
A
M
IVG
M
ILEP
I
P
AT
AI
SF
IAVTI
CV
I
G
S
NY
LLF
DAKE
LA
D
P
A
F
NAQ
K
QA
L
K
W
G
L
A
GFSS
T
T
V
WLVF
G
AF
I
F
AL
GYE
V
S
GLGRRIAL
F
LVK
F
MG
K
RTL
T
LGYA
I
V
I
I
D
I
L
LAP
F
TPSNTAR
T
GG
T
V
F
P
V
I
K
NLPPL
FK
S
F
PND
P
S
A
RRIG
G
YLMWM
MV
I
S
T
SL
S
S
S
MF
V
T
GA
APN
V
L
G
L
EF
V
SK
I
A
G
I
--
QISW
L
Q
WFL
CF
LP
V
G
V
ILL
I
I
A
PWL
S
YVLY
K
PEI
T
HS
E
E
V
A
TWA
GD
EL
KT
MG
A
L
TR
RE
W
T
L
I
GL
V
L
L
S
L
G
LW
V
FG
SEV
--
I
N
AT
A
VG
LL
A
V
S
LML
A
--
L
H
V
V
P
WKDI
T
R
YN
S
AWNTL
V
N
LA
T
L
V
V
M
A
N
GLT
RS
GFI
D
WFA
GTMST
HL
E
G
F
SP
NA
----
TVI
VL
V
L
VFY
FA
H
Y
L
FAS
L
SA
H
T
A
T
MLPV
IL
A
V
G
KGI
P
---
G
V
P
M
EQL
C
I
L
L
VL
SIG
I
M
G
C
LTPYATGPG
V
IIYG
C
GY
VKSK
DYWRLGAIFGVI
Y
ISM
LL
L
VG
WP
IL
A
M
W
N
fig|679207.4.peg.2846
Escherichia coli MS 107-1 (12-487/487)
LAPL
V
V
MG
VM
F
LIP
V
P
D
G
M
PPQ
AW
H
YFAVF
V
A
M
IVG
M
ILEP
I
P
AT
AI
SF
IAVTI
CV
I
G
S
NY
LLF
DAKE
LA
D
P
A
F
NAQ
K
QA
L
K
W
G
L
A
GFSS
T
T
V
WLVF
G
AF
I
F
AL
GYE
V
S
GLGRRIAL
F
LVK
F
MG
K
RTL
T
LGYA
I
V
I
I
D
I
L
LAP
F
TPSNTAR
T
GG
T
V
F
P
V
I
K
NLPPL
FK
S
F
PND
P
S
A
RRIG
G
YLMWM
MV
I
S
T
SL
S
S
S
MF
V
T
GA
APN
V
L
G
L
EF
V
SK
I
A
G
I
--
QISW
L
Q
WFL
CF
LP
V
G
V
ILL
I
I
A
PWL
S
YVLY
K
PEI
T
HS
E
E
V
A
TWA
GD
EL
KT
MG
A
L
TR
RE
W
T
L
I
GL
V
L
L
S
L
G
LW
V
FG
SEV
--
I
N
AT
A
VG
LL
A
V
S
LML
A
--
L
H
V
V
P
WKDI
T
R
YN
S
AWNTL
V
N
LA
T
L
V
V
M
A
N
GLT
RS
GFI
D
WFA
GTMST
HL
E
G
F
SP
NA
----
TVI
VL
V
L
VFY
FA
H
Y
L
FAS
L
SA
H
T
A
T
MLPV
IL
A
V
G
KGI
P
---
G
V
P
M
EQL
C
I
L
L
VL
SIG
I
M
G
C
LTPYATGPG
V
IIYG
C
GY
VKSK
DYWRLGAIFGVI
Y
ISM
LL
L
VG
WP
IL
A
M
W
N
fig|679204.3.peg.2652
Escherichia coli MS 145-7 (12-487/487)
LAPL
V
V
MG
VM
F
LIP
V
P
D
G
M
PPQ
AW
H
YFAVF
V
A
M
IVG
M
ILEP
I
P
AT
AI
SF
IAVTI
CV
I
G
S
NY
LLF
DAKE
LA
D
P
A
F
NAQ
K
QA
L
K
W
G
L
A
GFSS
T
T
V
WLVF
G
AF
I
F
AL
GYE
V
S
GLGRRIAL
F
LVK
F
MG
K
RTL
T
LGYA
I
V
I
I
D
I
L
LAP
F
TPSNTAR
T
GG
T
V
F
P
V
I
K
NLPPL
FK
S
F
PND
P
S
A
RRIG
G
YLMWM
MV
I
S
T
SL
S
S
S
MF
V
T
GA
APN
V
L
G
L
EF
V
SK
I
A
G
I
--
QISW
L
Q
WFL
CF
LP
V
G
V
ILL
I
I
A
PWL
S
YVLY
K
PEI
T
HS
E
E
V
A
TWA
GD
EL
KT
MG
A
L
TR
RE
W
T
L
I
GL
V
L
L
S
L
G
LW
V
FG
SEV
--
I
N
AT
A
VG
LL
A
V
S
LML
A
--
L
H
V
V
P
WKDI
T
R
YN
S
AWNTL
V
N
LA
T
L
V
V
M
A
N
GLT
RS
GFI
D
WFA
GTMST
HL
E
G
F
SP
NA
----
TVI
VL
V
L
VFY
FA
H
Y
L
FAS
L
SA
H
T
A
T
MLPV
IL
A
V
G
KGI
P
---
G
V
P
M
EQL
C
I
L
L
VL
SIG
I
M
G
C
LTPYATGPG
V
IIYG
C
GY
VKSK
DYWRLGAIFGVI
Y
ISM
LL
L
VG
WP
IL
A
M
W
N
fig|749533.3.peg.5423
Escherichia coli MS 84-1 (12-487/487)
LAPL
V
V
MG
VM
F
LIP
V
P
D
G
M
PPQ
AW
H
YFAVF
V
A
M
IVG
M
ILEP
I
P
AT
AI
SF
IAVTI
CV
I
G
S
NY
LLF
DAKE
LA
D
P
A
F
NAQ
K
QA
L
K
W
G
L
A
GFSS
T
T
V
WLVF
G
AF
I
F
AL
GYE
V
S
GLGRRIAL
F
LVK
F
MG
K
RTL
T
LGYA
I
V
I
I
D
I
L
LAP
F
TPSNTAR
T
GG
T
V
F
P
V
I
K
NLPPL
FK
S
F
PND
P
S
A
RRIG
G
YLMWM
MV
I
S
T
SL
S
S
S
MF
V
T
GA
APN
V
L
G
L
EF
V
SK
I
A
G
I
--
QISW
L
Q
WFL
CF
LP
V
G
V
ILL
I
I
A
PWL
S
YVLY
K
PEI
T
HS
E
E
V
A
TWA
GD
EL
KT
MG
A
L
TR
RE
W
T
L
I
GL
V
L
L
S
L
G
LW
V
FG
SEV
--
I
N
AT
A
VG
LL
A
V
S
LML
A
--
L
H
V
V
P
WKDI
T
R
YN
S
AWNTL
V
N
LA
T
L
V
V
M
A
N
GLT
RS
GFI
D
WFA
GTMST
HL
E
G
F
SP
NA
----
TVI
VL
V
L
VFY
FA
H
Y
L
FAS
L
SA
H
T
A
T
MLPV
IL
A
V
G
KGI
P
---
G
V
P
M
EQL
C
I
L
L
VL
SIG
I
M
G
C
LTPYATGPG
V
IIYG
C
GY
VKSK
DYWRLGAIFGVI
Y
ISM
LL
L
VG
WP
IL
A
M
W
N
fig|83334.1.peg.727
Escherichia coli O157:H7 (12-487/487)
LAPL
V
V
MG
VM
F
LIP
V
P
D
G
M
PPQ
AW
H
YFAVF
V
A
M
IVG
M
ILEP
I
P
AT
AI
SF
IAVTI
CV
I
G
S
NY
LLF
DAKE
LA
D
P
A
F
NAQ
K
QA
L
K
W
G
L
A
GFSS
T
T
V
WLVF
G
AF
I
F
AL
GYE
V
S
GLGRRIAL
F
LVK
F
MG
K
RTL
T
LGYA
I
V
I
I
D
I
L
LAP
F
TPSNTAR
T
GG
T
V
F
P
V
I
K
NLPPL
FK
S
F
PND
P
S
A
RRIG
G
YLMWM
MV
I
S
T
SL
S
S
S
MF
V
T
GA
APN
V
L
G
L
EF
V
SK
I
A
G
I
--
QISW
L
Q
WFL
CF
LP
V
G
V
ILL
I
I
A
PWL
S
YVLY
K
PEI
T
HS
E
E
V
A
TWA
GD
EL
KT
MG
A
L
TR
RE
W
T
L
I
GL
V
L
L
S
L
G
LW
V
FG
SEV
--
I
N
AT
A
VG
LL
A
V
S
LML
A
--
L
H
V
V
P
WKDI
T
R
YN
S
AWNTL
V
N
LA
T
L
V
V
M
A
N
GLT
RS
GFI
D
WFA
GTMST
HL
E
G
F
SP
NA
----
TVI
VL
V
L
VFY
FA
H
Y
L
FAS
L
SA
H
T
A
T
MLPV
IL
A
V
G
KGI
P
---
G
V
P
M
EQL
C
I
L
L
VL
SIG
I
M
G
C
LTPYATGPG
V
IIYG
C
GY
VKSK
DYWRLGAIFGVI
Y
ISM
LL
L
VG
WP
IL
A
M
W
N
fig|444448.5.peg.3349
Escherichia coli O157:H7 str. EC4045 (12-487/487)
LAPL
V
V
MG
VM
F
LIP
V
P
D
G
M
PPQ
AW
H
YFAVF
V
A
M
IVG
M
ILEP
I
P
AT
AI
SF
IAVTI
CV
I
G
S
NY
LLF
DAKE
LA
D
P
A
F
NAQ
K
QA
L
K
W
G
L
A
GFSS
T
T
V
WLVF
G
AF
I
F
AL
GYE
V
S
GLGRRIAL
F
LVK
F
MG
K
RTL
T
LGYA
I
V
I
I
D
I
L
LAP
F
TPSNTAR
T
GG
T
V
F
P
V
I
K
NLPPL
FK
S
F
PND
P
S
A
RRIG
G
YLMWM
MV
I
S
T
SL
S
S
S
MF
V
T
GA
APN
V
L
G
L
EF
V
SK
I
A
G
I
--
QISW
L
Q
WFL
CF
LP
V
G
V
ILL
I
I
A
PWL
S
YVLY
K
PEI
T
HS
E
E
V
A
TWA
GD
EL
KT
MG
A
L
TR
RE
W
T
L
I
GL
V
L
L
S
L
G
LW
V
FG
SEV
--
I
N
AT
A
VG
LL
A
V
S
LML
A
--
L
H
V
V
P
WKDI
T
R
YN
S
AWNTL
V
N
LA
T
L
V
V
M
A
N
GLT
RS
GFI
D
WFA
GTMST
HL
E
G
F
SP
NA
----
TVI
VL
V
L
VFY
FA
H
Y
L
FAS
L
SA
H
T
A
T
MLPV
IL
A
V
G
KGI
P
---
G
V
P
M
EQL
C
I
L
L
VL
SIG
I
M
G
C
LTPYATGPG
V
IIYG
C
GY
VKSK
DYWRLGAIFGVI
Y
ISM
LL
L
VG
WP
IL
A
M
W
N
fig|444451.5.peg.2311
Escherichia coli O157:H7 str. EC4196 (12-487/487)
LAPL
V
V
MG
VM
F
LIP
V
P
D
G
M
PPQ
AW
H
YFAVF
V
A
M
IVG
M
ILEP
I
P
AT
AI
SF
IAVTI
CV
I
G
S
NY
LLF
DAKE
LA
D
P
A
F
NAQ
K
QA
L
K
W
G
L
A
GFSS
T
T
V
WLVF
G
AF
I
F
AL
GYE
V
S
GLGRRIAL
F
LVK
F
MG
K
RTL
T
LGYA
I
V
I
I
D
I
L
LAP
F
TPSNTAR
T
GG
T
V
F
P
V
I
K
NLPPL
FK
S
F
PND
P
S
A
RRIG
G
YLMWM
MV
I
S
T
SL
S
S
S
MF
V
T
GA
APN
V
L
G
L
EF
V
SK
I
A
G
I
--
QISW
L
Q
WFL
CF
LP
V
G
V
ILL
I
I
A
PWL
S
YVLY
K
PEI
T
HS
E
E
V
A
TWA
GD
EL
KT
MG
A
L
TR
RE
W
T
L
I
GL
V
L
L
S
L
G
LW
V
FG
SEV
--
I
N
AT
A
VG
LL
A
V
S
LML
A
--
L
H
V
V
P
WKDI
T
R
YN
S
AWNTL
V
N
LA
T
L
V
V
M
A
N
GLT
RS
GFI
D
WFA
GTMST
HL
E
G
F
SP
NA
----
TVI
VL
V
L
VFY
FA
H
Y
L
FAS
L
SA
H
T
A
T
MLPV
IL
A
V
G
KGI
P
---
G
V
P
M
EQL
C
I
L
L
VL
SIG
I
M
G
C
LTPYATGPG
V
IIYG
C
GY
VKSK
DYWRLGAIFGVI
Y
ISM
LL
L
VG
WP
IL
A
M
W
N
fig|478007.5.peg.1008
Escherichia coli O157:H7 str. EC508 (12-487/487)
LAPL
V
V
MG
VM
F
LIP
V
P
D
G
M
PPQ
AW
H
YFAVF
V
A
M
IVG
M
ILEP
I
P
AT
AI
SF
IAVTI
CV
I
G
S
NY
LLF
DAKE
LA
D
P
A
F
NAQ
K
QA
L
K
W
G
L
A
GFSS
T
T
V
WLVF
G
AF
I
F
AL
GYE
V
S
GLGRRIAL
F
LVK
F
MG
K
RTL
T
LGYA
I
V
I
I
D
I
L
LAP
F
TPSNTAR
T
GG
T
V
F
P
V
I
K
NLPPL
FK
S
F
PND
P
S
A
RRIG
G
YLMWM
MV
I
S
T
SL
S
S
S
MF
V
T
GA
APN
V
L
G
L
EF
V
SK
I
A
G
I
--
QISW
L
Q
WFL
CF
LP
V
G
V
ILL
I
I
A
PWL
S
YVLY
K
PEI
T
HS
E
E
V
A
TWA
GD
EL
KT
MG
A
L
TR
RE
W
T
L
I
GL
V
L
L
S
L
G
LW
V
FG
SEV
--
I
N
AT
A
VG
LL
A
V
S
LML
A
--
L
H
V
V
P
WKDI
T
R
YN
S
AWNTL
V
N
LA
T
L
V
V
M
A
N
GLT
RS
GFI
D
WFA
GTMST
HL
E
G
F
SP
NA
----
TVI
VL
V
L
VFY
FA
H
Y
L
FAS
L
SA
H
T
A
T
MLPV
IL
A
V
G
KGI
P
---
G
V
P
M
EQL
C
I
L
L
VL
SIG
I
M
G
C
LTPYATGPG
V
IIYG
C
GY
VKSK
DYWRLGAIFGVI
Y
ISM
LL
L
VG
WP
IL
A
M
W
N
fig|637388.3.peg.1146
Escherichia coli O157:H7 str. FRIK2000 (12-487/487)
LAPL
V
V
MG
VM
F
LIP
V
P
D
G
M
PPQ
AW
H
YFAVF
V
A
M
IVG
M
ILEP
I
P
AT
AI
SF
IAVTI
CV
I
G
S
NY
LLF
DAKE
LA
D
P
A
F
NAQ
K
QA
L
K
W
G
L
A
GFSS
T
T
V
WLVF
G
AF
I
F
AL
GYE
V
S
GLGRRIAL
F
LVK
F
MG
K
RTL
T
LGYA
I
V
I
I
D
I
L
LAP
F
TPSNTAR
T
GG
T
V
F
P
V
I
K
NLPPL
FK
S
F
PND
P
S
A
RRIG
G
YLMWM
MV
I
S
T
SL
S
S
S
MF
V
T
GA
APN
V
L
G
L
EF
V
SK
I
A
G
I
--
QISW
L
Q
WFL
CF
LP
V
G
V
ILL
I
I
A
PWL
S
YVLY
K
PEI
T
HS
E
E
V
A
TWA
GD
EL
KT
MG
A
L
TR
RE
W
T
L
I
GL
V
L
L
S
L
G
LW
V
FG
SEV
--
I
N
AT
A
VG
LL
A
V
S
LML
A
--
L
H
V
V
P
WKDI
T
R
YN
S
AWNTL
V
N
LA
T
L
V
V
M
A
N
GLT
RS
GFI
D
WFA
GTMST
HL
E
G
F
SP
NA
----
TVI
VL
V
L
VFY
FA
H
Y
L
FAS
L
SA
H
T
A
T
MLPV
IL
A
V
G
KGI
P
---
G
V
P
M
EQL
C
I
L
L
VL
SIG
I
M
G
C
LTPYATGPG
V
IIYG
C
GY
VKSK
DYWRLGAIFGVI
Y
ISM
LL
L
VG
WP
IL
A
M
W
N
fig|570506.3.peg.3683
Escherichia coli O157:H7 str. FRIK966 (12-487/487)
LAPL
V
V
MG
VM
F
LIP
V
P
D
G
M
PPQ
AW
H
YFAVF
V
A
M
IVG
M
ILEP
I
P
AT
AI
SF
IAVTI
CV
I
G
S
NY
LLF
DAKE
LA
D
P
A
F
NAQ
K
QA
L
K
W
G
L
A
GFSS
T
T
V
WLVF
G
AF
I
F
AL
GYE
V
S
GLGRRIAL
F
LVK
F
MG
K
RTL
T
LGYA
I
V
I
I
D
I
L
LAP
F
TPSNTAR
T
GG
T
V
F
P
V
I
K
NLPPL
FK
S
F
PND
P
S
A
RRIG
G
YLMWM
MV
I
S
T
SL
S
S
S
MF
V
T
GA
APN
V
L
G
L
EF
V
SK
I
A
G
I
--
QISW
L
Q
WFL
CF
LP
V
G
V
ILL
I
I
A
PWL
S
YVLY
K
PEI
T
HS
E
E
V
A
TWA
GD
EL
KT
MG
A
L
TR
RE
W
T
L
I
GL
V
L
L
S
L
G
LW
V
FG
SEV
--
I
N
AT
A
VG
LL
A
V
S
LML
A
--
L
H
V
V
P
WKDI
T
R
YN
S
AWNTL
V
N
LA
T
L
V
V
M
A
N
GLT
RS
GFI
D
WFA
GTMST
HL
E
G
F
SP
NA
----
TVI
VL
V
L
VFY
FA
H
Y
L
FAS
L
SA
H
T
A
T
MLPV
IL
A
V
G
KGI
P
---
G
V
P
M
EQL
C
I
L
L
VL
SIG
I
M
G
C
LTPYATGPG
V
IIYG
C
GY
VKSK
DYWRLGAIFGVI
Y
ISM
LL
L
VG
WP
IL
A
M
W
N
fig|573235.3.peg.695
Escherichia coli O26:H11 str. 11368 (12-487/487)
LAPL
V
V
MG
VM
F
LIP
V
P
D
G
M
PPQ
AW
H
YFAVF
V
A
M
IVG
M
ILEP
I
P
AT
AI
SF
IAVTI
CV
I
G
S
NY
LLF
DAKE
LA
D
P
A
F
NAQ
K
QA
L
K
W
G
L
A
GFSS
T
T
V
WLVF
G
AF
I
F
AL
GYE
V
S
GLGRRIAL
F
LVK
F
MG
K
RTL
T
LGYA
I
V
I
I
D
I
L
LAP
F
TPSNTAR
T
GG
T
V
F
P
V
I
K
NLPPL
FK
S
F
PND
P
S
A
RRIG
G
YLMWM
MV
I
S
T
SL
S
S
S
MF
V
T
GA
APN
V
L
G
L
EF
V
SK
I
A
G
I
--
QISW
L
Q
WFL
CF
LP
V
G
V
ILL
I
I
A
PWL
S
YVLY
K
PEI
T
HS
E
E
V
A
TWA
GD
EL
KT
MG
A
L
TR
RE
W
T
L
I
GL
V
L
L
S
L
G
LW
V
FG
SEV
--
I
N
AT
A
VG
LL
A
V
S
LML
A
--
L
H
V
V
P
WKDI
T
R
YN
S
AWNTL
V
N
LA
T
L
V
V
M
A
N
GLT
RS
GFI
D
WFA
GTMST
HL
E
G
F
SP
NA
----
TVI
VL
V
L
VFY
FA
H
Y
L
FAS
L
SA
H
T
A
T
MLPV
IL
A
V
G
KGI
P
---
G
V
P
M
EQL
C
I
L
L
VL
SIG
I
M
G
C
LTPYATGPG
V
IIYG
C
GY
VKSK
DYWRLGAIFGVI
Y
ISM
LL
L
VG
WP
IL
A
M
W
N
fig|316407.3.peg.595
Escherichia coli W3110 (12-487/487)
LAPL
V
V
MG
VM
F
LIP
V
P
D
G
M
PPQ
AW
H
YFAVF
V
A
M
IVG
M
ILEP
I
P
AT
AI
SF
IAVTI
CV
I
G
S
NY
LLF
DAKE
LA
D
P
A
F
NAQ
K
QA
L
K
W
G
L
A
GFSS
T
T
V
WLVF
G
AF
I
F
AL
GYE
V
S
GLGRRIAL
F
LVK
F
MG
K
RTL
T
LGYA
I
V
I
I
D
I
L
LAP
F
TPSNTAR
T
GG
T
V
F
P
V
I
K
NLPPL
FK
S
F
PND
P
S
A
RRIG
G
YLMWM
MV
I
S
T
SL
S
S
S
MF
V
T
GA
APN
V
L
G
L
EF
V
SK
I
A
G
I
--
QISW
L
Q
WFL
CF
LP
V
G
V
ILL
I
I
A
PWL
S
YVLY
K
PEI
T
HS
E
E
V
A
TWA
GD
EL
KT
MG
A
L
TR
RE
W
T
L
I
GL
V
L
L
S
L
G
LW
V
FG
SEV
--
I
N
AT
A
VG
LL
A
V
S
LML
A
--
L
H
V
V
P
WKDI
T
R
YN
S
AWNTL
V
N
LA
T
L
V
V
M
A
N
GLT
RS
GFI
D
WFA
GTMST
HL
E
G
F
SP
NA
----
TVI
VL
V
L
VFY
FA
H
Y
L
FAS
L
SA
H
T
A
T
MLPV
IL
A
V
G
KGI
P
---
G
V
P
M
EQL
C
I
L
L
VL
SIG
I
M
G
C
LTPYATGPG
V
IIYG
C
GY
VKSK
DYWRLGAIFGVI
Y
ISM
LL
L
VG
WP
IL
A
M
W
N
fig|316385.7.peg.577
Escherichia coli str. K-12 substr. DH10B (12-487/487)
LAPL
V
V
MG
VM
F
LIP
V
P
D
G
M
PPQ
AW
H
YFAVF
V
A
M
IVG
M
ILEP
I
P
AT
AI
SF
IAVTI
CV
I
G
S
NY
LLF
DAKE
LA
D
P
A
F
NAQ
K
QA
L
K
W
G
L
A
GFSS
T
T
V
WLVF
G
AF
I
F
AL
GYE
V
S
GLGRRIAL
F
LVK
F
MG
K
RTL
T
LGYA
I
V
I
I
D
I
L
LAP
F
TPSNTAR
T
GG
T
V
F
P
V
I
K
NLPPL
FK
S
F
PND
P
S
A
RRIG
G
YLMWM
MV
I
S
T
SL
S
S
S
MF
V
T
GA
APN
V
L
G
L
EF
V
SK
I
A
G
I
--
QISW
L
Q
WFL
CF
LP
V
G
V
ILL
I
I
A
PWL
S
YVLY
K
PEI
T
HS
E
E
V
A
TWA
GD
EL
KT
MG
A
L
TR
RE
W
T
L
I
GL
V
L
L
S
L
G
LW
V
FG
SEV
--
I
N
AT
A
VG
LL
A
V
S
LML
A
--
L
H
V
V
P
WKDI
T
R
YN
S
AWNTL
V
N
LA
T
L
V
V
M
A
N
GLT
RS
GFI
D
WFA
GTMST
HL
E
G
F
SP
NA
----
TVI
VL
V
L
VFY
FA
H
Y
L
FAS
L
SA
H
T
A
T
MLPV
IL
A
V
G
KGI
P
---
G
V
P
M
EQL
C
I
L
L
VL
SIG
I
M
G
C
LTPYATGPG
V
IIYG
C
GY
VKSK
DYWRLGAIFGVI
Y
ISM
LL
L
VG
WP
IL
A
M
W
N
fig|316385.7.peg.688
Escherichia coli str. K-12 substr. DH10B (12-487/487)
LAPL
V
V
MG
VM
F
LIP
V
P
D
G
M
PPQ
AW
H
YFAVF
V
A
M
IVG
M
ILEP
I
P
AT
AI
SF
IAVTI
CV
I
G
S
NY
LLF
DAKE
LA
D
P
A
F
NAQ
K
QA
L
K
W
G
L
A
GFSS
T
T
V
WLVF
G
AF
I
F
AL
GYE
V
S
GLGRRIAL
F
LVK
F
MG
K
RTL
T
LGYA
I
V
I
I
D
I
L
LAP
F
TPSNTAR
T
GG
T
V
F
P
V
I
K
NLPPL
FK
S
F
PND
P
S
A
RRIG
G
YLMWM
MV
I
S
T
SL
S
S
S
MF
V
T
GA
APN
V
L
G
L
EF
V
SK
I
A
G
I
--
QISW
L
Q
WFL
CF
LP
V
G
V
ILL
I
I
A
PWL
S
YVLY
K
PEI
T
HS
E
E
V
A
TWA
GD
EL
KT
MG
A
L
TR
RE
W
T
L
I
GL
V
L
L
S
L
G
LW
V
FG
SEV
--
I
N
AT
A
VG
LL
A
V
S
LML
A
--
L
H
V
V
P
WKDI
T
R
YN
S
AWNTL
V
N
LA
T
L
V
V
M
A
N
GLT
RS
GFI
D
WFA
GTMST
HL
E
G
F
SP
NA
----
TVI
VL
V
L
VFY
FA
H
Y
L
FAS
L
SA
H
T
A
T
MLPV
IL
A
V
G
KGI
P
---
G
V
P
M
EQL
C
I
L
L
VL
SIG
I
M
G
C
LTPYATGPG
V
IIYG
C
GY
VKSK
DYWRLGAIFGVI
Y
ISM
LL
L
VG
WP
IL
A
M
W
N
fig|1040638.4.peg.5305
Escherichia coli O104:H4 str. LB226692
M
APL
V
V
MG
VM
F
LIP
V
P
D
G
M
PPQ
AW
H
YFAVF
V
A
M
IVG
M
ILEP
I
P
AT
AI
SF
IAVTI
CV
I
G
S
NY
LLF
DAKE
LA
D
P
A
F
NAQ
K
QA
L
K
W
G
L
A
GFSS
T
T
V
WLVF
G
AF
I
F
AL
GYE
V
S
GLGRRIAL
F
LVK
F
MG
K
RTL
T
LGYA
I
V
I
I
D
I
L
LAP
F
TPSNTAR
T
GG
T
V
F
P
V
I
K
NLPPL
FK
S
F
PND
P
S
A
RRIG
G
YLMWM
MV
I
S
T
SL
S
S
S
MF
V
T
GA
APN
V
L
G
L
EF
V
SK
I
A
G
I
--
QISW
L
Q
WFL
CF
LP
V
G
V
ILL
I
I
A
PWL
S
YVLY
K
PEI
T
HS
E
E
V
A
TWA
GD
EL
KT
MG
A
L
TR
RE
W
T
L
I
GL
V
L
L
S
L
G
LW
V
FG
SEV
--
I
N
AT
A
VG
LL
A
V
S
LML
A
--
L
H
V
V
P
WKDI
T
R
YN
S
AWNTL
V
N
LA
T
L
V
V
M
A
N
GLT
RS
GFI
D
WFA
GTMST
HL
E
G
F
SP
NA
----
TVI
VL
V
L
VFY
FA
H
Y
L
FAS
L
SA
H
T
A
T
MLPV
IL
A
V
G
KGI
P
---
G
V
P
M
EQL
C
I
L
L
VL
SIG
I
M
G
C
LTPYATGPG
V
IIYG
C
GY
VKSK
DYWRLGAIFGVI
Y
ISM
LL
L
VG
WP
IL
A
M
W
N
fig|6666666.5357.peg.395
Escherichia coli TY-2482
M
APL
V
V
MG
VM
F
LIP
V
P
D
G
M
PPQ
AW
H
YFAVF
V
A
M
IVG
M
ILEP
I
P
AT
AI
SF
IAVTI
CV
I
G
S
NY
LLF
DAKE
LA
D
P
A
F
NAQ
K
QA
L
K
W
G
L
A
GFSS
T
T
V
WLVF
G
AF
I
F
AL
GYE
V
S
GLGRRIAL
F
LVK
F
MG
K
RTL
T
LGYA
I
V
I
I
D
I
L
LAP
F
TPSNTAR
T
GG
T
V
F
P
V
I
K
NLPPL
FK
S
F
PND
P
S
A
RRIG
G
YLMWM
MV
I
S
T
SL
S
S
S
MF
V
T
GA
APN
V
L
G
L
EF
V
SK
I
A
G
I
--
QISW
L
Q
WFL
CF
LP
V
G
V
ILL
I
I
A
PWL
S
YVLY
K
PEI
T
HS
E
E
V
A
TWA
GD
EL
KT
MG
A
L
TR
RE
W
T
L
I
GL
V
L
L
S
L
G
LW
V
FG
SEV
--
I
N
AT
A
VG
LL
A
V
S
LML
A
--
L
H
V
V
P
WKDI
T
R
YN
S
AWNTL
V
N
LA
T
L
V
V
M
A
N
GLT
RS
GFI
D
WFA
GTMST
HL
E
G
F
SP
NA
----
TVI
VL
V
L
VFY
FA
H
Y
L
FAS
L
SA
H
T
A
T
MLPV
IL
A
V
G
KGI
P
---
G
V
P
M
EQL
C
I
L
L
VL
SIG
I
M
G
C
LTPYATGPG
V
IIYG
C
GY
VKSK
DYWRLGAIFGVI
Y
ISM
LL
L
VG
WP
IL
A
M
W
N
fig|358709.5.peg.1935
Escherichia coli 101-1
M
APL
V
V
MG
VM
F
LIP
V
P
D
G
M
PPQ
AW
H
YFAVF
V
A
M
IVG
M
ILEP
I
P
AT
AI
SF
IAVTI
CV
I
G
S
NY
LLF
DAKE
LA
D
P
A
F
NAQ
K
QA
L
K
W
G
L
A
GFSS
T
T
V
WLVF
G
AF
I
F
AL
GYE
V
S
GLGRRIAL
F
LVK
F
MG
K
RTL
T
LGYA
I
V
I
I
D
I
L
LAP
F
TPSNTAR
T
GG
T
V
F
P
V
I
K
NLPPL
FK
S
F
PND
P
S
A
RRIG
G
YLMWM
MV
I
S
T
SL
S
S
S
MF
V
T
GA
APN
V
L
G
L
EF
V
SK
I
A
G
I
--
QISW
L
Q
WFL
CF
LP
V
G
V
ILL
I
I
A
PWL
S
YVLY
K
PEI
T
HS
E
E
V
A
TWA
GD
EL
KT
MG
A
L
TR
RE
W
T
L
I
GL
V
L
L
S
L
G
LW
V
FG
SEV
--
I
N
AT
A
VG
LL
A
V
S
LML
A
--
L
H
V
V
P
WKDI
T
R
YN
S
AWNTL
V
N
LA
T
L
V
V
M
A
N
GLT
RS
GFI
D
WFA
GTMST
HL
E
G
F
SP
NA
----
TVI
VL
V
L
VFY
FA
H
Y
L
FAS
L
SA
H
T
A
T
MLPV
IL
A
V
G
KGI
P
---
G
V
P
M
EQL
C
I
L
L
VL
SIG
I
M
G
C
LTPYATGPG
V
IIYG
C
GY
VKSK
DYWRLGAIFGVI
Y
ISM
LL
L
VG
WP
IL
A
M
W
N
fig|562.371.peg.2872
Escherichia coli 1044A
M
APL
V
V
MG
VM
F
LIP
V
P
D
G
M
PPQ
AW
H
YFAVF
V
A
M
IVG
M
ILEP
I
P
AT
AI
SF
IAVTI
CV
I
G
S
NY
LLF
DAKE
LA
D
P
A
F
NAQ
K
QA
L
K
W
G
L
A
GFSS
T
T
V
WLVF
G
AF
I
F
AL
GYE
V
S
GLGRRIAL
F
LVK
F
MG
K
RTL
T
LGYA
I
V
I
I
D
I
L
LAP
F
TPSNTAR
T
GG
T
V
F
P
V
I
K
NLPPL
FK
S
F
PND
P
S
A
RRIG
G
YLMWM
MV
I
S
T
SL
S
S
S
MF
V
T
GA
APN
V
L
G
L
EF
V
SK
I
A
G
I
--
QISW
L
Q
WFL
CF
LP
V
G
V
ILL
I
I
A
PWL
S
YVLY
K
PEI
T
HS
E
E
V
A
TWA
GD
EL
KT
MG
A
L
TR
RE
W
T
L
I
GL
V
L
L
S
L
G
LW
V
FG
SEV
--
I
N
AT
A
VG
LL
A
V
S
LML
A
--
L
H
V
V
P
WKDI
T
R
YN
S
AWNTL
V
N
LA
T
L
V
V
M
A
N
GLT
RS
GFI
D
WFA
GTMST
HL
E
G
F
SP
NA
----
TVI
VL
V
L
VFY
FA
H
Y
L
FAS
L
SA
H
T
A
T
MLPV
IL
A
V
G
KGI
P
---
G
V
P
M
EQL
C
I
L
L
VL
SIG
I
M
G
C
LTPYATGPG
V
IIYG
C
GY
VKSK
DYWRLGAIFGVI
Y
ISM
LL
L
VG
WP
IL
A
M
W
N
fig|562.373.peg.3122
Escherichia coli 1125A
M
APL
V
V
MG
VM
F
LIP
V
P
D
G
M
PPQ
AW
H
YFAVF
V
A
M
IVG
M
ILEP
I
P
AT
AI
SF
IAVTI
CV
I
G
S
NY
LLF
DAKE
LA
D
P
A
F
NAQ
K
QA
L
K
W
G
L
A
GFSS
T
T
V
WLVF
G
AF
I
F
AL
GYE
V
S
GLGRRIAL
F
LVK
F
MG
K
RTL
T
LGYA
I
V
I
I
D
I
L
LAP
F
TPSNTAR
T
GG
T
V
F
P
V
I
K
NLPPL
FK
S
F
PND
P
S
A
RRIG
G
YLMWM
MV
I
S
T
SL
S
S
S
MF
V
T
GA
APN
V
L
G
L
EF
V
SK
I
A
G
I
--
QISW
L
Q
WFL
CF
LP
V
G
V
ILL
I
I
A
PWL
S
YVLY
K
PEI
T
HS
E
E
V
A
TWA
GD
EL
KT
MG
A
L
TR
RE
W
T
L
I
GL
V
L
L
S
L
G
LW
V
FG
SEV
--
I
N
AT
A
VG
LL
A
V
S
LML
A
--
L
H
V
V
P
WKDI
T
R
YN
S
AWNTL
V
N
LA
T
L
V
V
M
A
N
GLT
RS
GFI
D
WFA
GTMST
HL
E
G
F
SP
NA
----
TVI
VL
V
L
VFY
FA
H
Y
L
FAS
L
SA
H
T
A
T
MLPV
IL
A
V
G
KGI
P
---
G
V
P
M
EQL
C
I
L
L
VL
SIG
I
M
G
C
LTPYATGPG
V
IIYG
C
GY
VKSK
DYWRLGAIFGVI
Y
ISM
LL
L
VG
WP
IL
A
M
W
N
fig|562.372.peg.1602
Escherichia coli 1212A
M
APL
V
V
MG
VM
F
LIP
V
P
D
G
M
PPQ
AW
H
YFAVF
V
A
M
IVG
M
ILEP
I
P
AT
AI
SF
IAVTI
CV
I
G
S
NY
LLF
DAKE
LA
D
P
A
F
NAQ
K
QA
L
K
W
G
L
A
GFSS
T
T
V
WLVF
G
AF
I
F
AL
GYE
V
S
GLGRRIAL
F
LVK
F
MG
K
RTL
T
LGYA
I
V
I
I
D
I
L
LAP
F
TPSNTAR
T
GG
T
V
F
P
V
I
K
NLPPL
FK
S
F
PND
P
S
A
RRIG
G
YLMWM
MV
I
S
T
SL
S
S
S
MF
V
T
GA
APN
V
L
G
L
EF
V
SK
I
A
G
I
--
QISW
L
Q
WFL
CF
LP
V
G
V
ILL
I
I
A
PWL
S
YVLY
K
PEI
T
HS
E
E
V
A
TWA
GD
EL
KT
MG
A
L
TR
RE
W
T
L
I
GL
V
L
L
S
L
G
LW
V
FG
SEV
--
I
N
AT
A
VG
LL
A
V
S
LML
A
--
L
H
V
V
P
WKDI
T
R
YN
S
AWNTL
V
N
LA
T
L
V
V
M
A
N
GLT
RS
GFI
D
WFA
GTMST
HL
E
G
F
SP
NA
----
TVI
VL
V
L
VFY
FA
H
Y
L
FAS
L
SA
H
T
A
T
MLPV
IL
A
V
G
KGI
P
---
G
V
P
M
EQL
C
I
L
L
VL
SIG
I
M
G
C
LTPYATGPG
V
IIYG
C
GY
VKSK
DYWRLGAIFGVI
Y
ISM
LL
L
VG
WP
IL
A
M
W
N
fig|670888.3.peg.1180
Escherichia coli 1827-70
M
APL
V
V
MG
VM
F
LIP
V
P
D
G
M
PPQ
AW
H
YFAVF
V
A
M
IVG
M
ILEP
I
P
AT
AI
SF
IAVTI
CV
I
G
S
NY
LLF
DAKE
LA
D
P
A
F
NAQ
K
QA
L
K
W
G
L
A
GFSS
T
T
V
WLVF
G
AF
I
F
AL
GYE
V
S
GLGRRIAL
F
LVK
F
MG
K
RTL
T
LGYA
I
V
I
I
D
I
L
LAP
F
TPSNTAR
T
GG
T
V
F
P
V
I
K
NLPPL
FK
S
F
PND
P
S
A
RRIG
G
YLMWM
MV
I
S
T
SL
S
S
S
MF
V
T
GA
APN
V
L
G
L
EF
V
SK
I
A
G
I
--
QISW
L
Q
WFL
CF
LP
V
G
V
ILL
I
I
A
PWL
S
YVLY
K
PEI
T
HS
E
E
V
A
TWA
GD
EL
KT
MG
A
L
TR
RE
W
T
L
I
GL
V
L
L
S
L
G
LW
V
FG
SEV
--
I
N
AT
A
VG
LL
A
V
S
LML
A
--
L
H
V
V
P
WKDI
T
R
YN
S
AWNTL
V
N
LA
T
L
V
V
M
A
N
GLT
RS
GFI
D
WFA
GTMST
HL
E
G
F
SP
NA
----
TVI
VL
V
L
VFY
FA
H
Y
L
FAS
L
SA
H
T
A
T
MLPV
IL
A
V
G
KGI
P
---
G
V
P
M
EQL
C
I
L
L
VL
SIG
I
M
G
C
LTPYATGPG
V
IIYG
C
GY
VKSK
DYWRLGAIFGVI
Y
ISM
LL
L
VG
WP
IL
A
M
W
N
fig|344610.7.peg.1076
Escherichia coli 53638
M
APL
V
V
MG
VM
F
LIP
V
P
D
G
M
PPQ
AW
H
YFAVF
V
A
M
IVG
M
ILEP
I
P
AT
AI
SF
IAVTI
CV
I
G
S
NY
LLF
DAKE
LA
D
P
A
F
NAQ
K
QA
L
K
W
G
L
A
GFSS
T
T
V
WLVF
G
AF
I
F
AL
GYE
V
S
GLGRRIAL
F
LVK
F
MG
K
RTL
T
LGYA
I
V
I
I
D
I
L
LAP
F
TPSNTAR
T
GG
T
V
F
P
V
I
K
NLPPL
FK
S
F
PND
P
S
A
RRIG
G
YLMWM
MV
I
S
T
SL
S
S
S
MF
V
T
GA
APN
V
L
G
L
EF
V
SK
I
A
G
I
--
QISW
L
Q
WFL
CF
LP
V
G
V
ILL
I
I
A
PWL
S
YVLY
K
PEI
T
HS
E
E
V
A
TWA
GD
EL
KT
MG
A
L
TR
RE
W
T
L
I
GL
V
L
L
S
L
G
LW
V
FG
SEV
--
I
N
AT
A
VG
LL
A
V
S
LML
A
--
L
H
V
V
P
WKDI
T
R
YN
S
AWNTL
V
N
LA
T
L
V
V
M
A
N
GLT
RS
GFI
D
WFA
GTMST
HL
E
G
F
SP
NA
----
TVI
VL
V
L
VFY
FA
H
Y
L
FAS
L
SA
H
T
A
T
MLPV
IL
A
V
G
KGI
P
---
G
V
P
M
EQL
C
I
L
L
VL
SIG
I
M
G
C
LTPYATGPG
V
IIYG
C
GY
VKSK
DYWRLGAIFGVI
Y
ISM
LL
L
VG
WP
IL
A
M
W
N
fig|562.374.peg.5376
Escherichia coli 536A
M
APL
V
V
MG
VM
F
LIP
V
P
D
G
M
PPQ
AW
H
YFAVF
V
A
M
IVG
M
ILEP
I
P
AT
AI
SF
IAVTI
CV
I
G
S
NY
LLF
DAKE
LA
D
P
A
F
NAQ
K
QA
L
K
W
G
L
A
GFSS
T
T
V
WLVF
G
AF
I
F
AL
GYE
V
S
GLGRRIAL
F
LVK
F
MG
K
RTL
T
LGYA
I
V
I
I
D
I
L
LAP
F
TPSNTAR
T
GG
T
V
F
P
V
I
K
NLPPL
FK
S
F
PND
P
S
A
RRIG
G
YLMWM
MV
I
S
T
SL
S
S
S
MF
V
T
GA
APN
V
L
G
L
EF
V
SK
I
A
G
I
--
QISW
L
Q
WFL
CF
LP
V
G
V
ILL
I
I
A
PWL
S
YVLY
K
PEI
T
HS
E
E
V
A
TWA
GD
EL
KT
MG
A
L
TR
RE
W
T
L
I
GL
V
L
L
S
L
G
LW
V
FG
SEV
--
I
N
AT
A
VG
LL
A
V
S
LML
A
--
L
H
V
V
P
WKDI
T
R
YN
S
AWNTL
V
N
LA
T
L
V
V
M
A
N
GLT
RS
GFI
D
WFA
GTMST
HL
E
G
F
SP
NA
----
TVI
VL
V
L
VFY
FA
H
Y
L
FAS
L
SA
H
T
A
T
MLPV
IL
A
V
G
KGI
P
---
G
V
P
M
EQL
C
I
L
L
VL
SIG
I
M
G
C
LTPYATGPG
V
IIYG
C
GY
VKSK
DYWRLGAIFGVI
Y
ISM
LL
L
VG
WP
IL
A
M
W
N
fig|481805.6.peg.3238
Escherichia coli ATCC 8739
M
APL
V
V
MG
VM
F
LIP
V
P
D
G
M
PPQ
AW
H
YFAVF
V
A
M
IVG
M
ILEP
I
P
AT
AI
SF
IAVTI
CV
I
G
S
NY
LLF
DAKE
LA
D
P
A
F
NAQ
K
QA
L
K
W
G
L
A
GFSS
T
T
V
WLVF
G
AF
I
F
AL
GYE
V
S
GLGRRIAL
F
LVK
F
MG
K
RTL
T
LGYA
I
V
I
I
D
I
L
LAP
F
TPSNTAR
T
GG
T
V
F
P
V
I
K
NLPPL
FK
S
F
PND
P
S
A
RRIG
G
YLMWM
MV
I
S
T
SL
S
S
S
MF
V
T
GA
APN
V
L
G
L
EF
V
SK
I
A
G
I
--
QISW
L
Q
WFL
CF
LP
V
G
V
ILL
I
I
A
PWL
S
YVLY
K
PEI
T
HS
E
E
V
A
TWA
GD
EL
KT
MG
A
L
TR
RE
W
T
L
I
GL
V
L
L
S
L
G
LW
V
FG
SEV
--
I
N
AT
A
VG
LL
A
V
S
LML
A
--
L
H
V
V
P
WKDI
T
R
YN
S
AWNTL
V
N
LA
T
L
V
V
M
A
N
GLT
RS
GFI
D
WFA
GTMST
HL
E
G
F
SP
NA
----
TVI
VL
V
L
VFY
FA
H
Y
L
FAS
L
SA
H
T
A
T
MLPV
IL
A
V
G
KGI
P
---
G
V
P
M
EQL
C
I
L
L
VL
SIG
I
M
G
C
LTPYATGPG
V
IIYG
C
GY
VKSK
DYWRLGAIFGVI
Y
ISM
LL
L
VG
WP
IL
A
M
W
N
fig|413997.3.peg.611
Escherichia coli B str. REL606
M
APL
V
V
MG
VM
F
LIP
V
P
D
G
M
PPQ
AW
H
YFAVF
V
A
M
IVG
M
ILEP
I
P
AT
AI
SF
IAVTI
CV
I
G
S
NY
LLF
DAKE
LA
D
P
A
F
NAQ
K
QA
L
K
W
G
L
A
GFSS
T
T
V
WLVF
G
AF
I
F
AL
GYE
V
S
GLGRRIAL
F
LVK
F
MG
K
RTL
T
LGYA
I
V
I
I
D
I
L
LAP
F
TPSNTAR
T
GG
T
V
F
P
V
I
K
NLPPL
FK
S
F
PND
P
S
A
RRIG
G
YLMWM
MV
I
S
T
SL
S
S
S
MF
V
T
GA
APN
V
L
G
L
EF
V
SK
I
A
G
I
--
QISW
L
Q
WFL
CF
LP
V
G
V
ILL
I
I
A
PWL
S
YVLY
K
PEI
T
HS
E
E
V
A
TWA
GD
EL
KT
MG
A
L
TR
RE
W
T
L
I
GL
V
L
L
S
L
G
LW
V
FG
SEV
--
I
N
AT
A
VG
LL
A
V
S
LML
A
--
L
H
V
V
P
WKDI
T
R
YN
S
AWNTL
V
N
LA
T
L
V
V
M
A
N
GLT
RS
GFI
D
WFA
GTMST
HL
E
G
F
SP
NA
----
TVI
VL
V
L
VFY
FA
H
Y
L
FAS
L
SA
H
T
A
T
MLPV
IL
A
V
G
KGI
P
---
G
V
P
M
EQL
C
I
L
L
VL
SIG
I
M
G
C
LTPYATGPG
V
IIYG
C
GY
VKSK
DYWRLGAIFGVI
Y
ISM
LL
L
VG
WP
IL
A
M
W
N
fig|550676.3.peg.80
Escherichia coli B185
M
APL
V
V
MG
VM
F
LIP
V
P
D
G
M
PPQ
AW
H
YFAVF
V
A
M
IVG
M
ILEP
I
P
AT
AI
SF
IAVTI
CV
I
G
S
NY
LLF
DAKE
LA
D
P
A
F
NAQ
K
QA
L
K
W
G
L
A
GFSS
T
T
V
WLVF
G
AF
I
F
AL
GYE
V
S
GLGRRIAL
F
LVK
F
MG
K
RTL
T
LGYA
I
V
I
I
D
I
L
LAP
F
TPSNTAR
T
GG
T
V
F
P
V
I
K
NLPPL
FK
S
F
PND
P
S
A
RRIG
G
YLMWM
MV
I
S
T
SL
S
S
S
MF
V
T
GA
APN
V
L
G
L
EF
V
SK
I
A
G
I
--
QISW
L
Q
WFL
CF
LP
V
G
V
ILL
I
I
A
PWL
S
YVLY
K
PEI
T
HS
E
E
V
A
TWA
GD
EL
KT
MG
A
L
TR
RE
W
T
L
I
GL
V
L
L
S
L
G
LW
V
FG
SEV
--
I
N
AT
A
VG
LL
A
V
S
LML
A
--
L
H
V
V
P
WKDI
T
R
YN
S
AWNTL
V
N
LA
T
L
V
V
M
A
N
GLT
RS
GFI
D
WFA
GTMST
HL
E
G
F
SP
NA
----
TVI
VL
V
L
VFY
FA
H
Y
L
FAS
L
SA
H
T
A
T
MLPV
IL
A
V
G
KGI
P
---
G
V
P
M
EQL
C
I
L
L
VL
SIG
I
M
G
C
LTPYATGPG
V
IIYG
C
GY
VKSK
DYWRLGAIFGVI
Y
ISM
LL
L
VG
WP
IL
A
M
W
N
fig|550677.3.peg.1032
Escherichia coli B354
M
APL
V
V
MG
VM
F
LIP
V
P
D
G
M
PPQ
AW
H
YFAVF
V
A
M
IVG
M
ILEP
I
P
AT
AI
SF
IAVTI
CV
I
G
S
NY
LLF
DAKE
LA
D
P
A
F
NAQ
K
QA
L
K
W
G
L
A
GFSS
T
T
V
WLVF
G
AF
I
F
AL
GYE
V
S
GLGRRIAL
F
LVK
F
MG
K
RTL
T
LGYA
I
V
I
I
D
I
L
LAP
F
TPSNTAR
T
GG
T
V
F
P
V
I
K
NLPPL
FK
S
F
PND
P
S
A
RRIG
G
YLMWM
MV
I
S
T
SL
S
S
S
MF
V
T
GA
APN
V
L
G
L
EF
V
SK
I
A
G
I
--
QISW
L
Q
WFL
CF
LP
V
G
V
ILL
I
I
A
PWL
S
YVLY
K
PEI
T
HS
E
E
V
A
TWA
GD
EL
KT
MG
A
L
TR
RE
W
T
L
I
GL
V
L
L
S
L
G
LW
V
FG
SEV
--
I
N
AT
A
VG
LL
A
V
S
LML
A
--
L
H
V
V
P
WKDI
T
R
YN
S
AWNTL
V
N
LA
T
L
V
V
M
A
N
GLT
RS
GFI
D
WFA
GTMST
HL
E
G
F
SP
NA
----
TVI
VL
V
L
VFY
FA
H
Y
L
FAS
L
SA
H
T
A
T
MLPV
IL
A
V
G
KGI
P
---
G
V
P
M
EQL
C
I
L
L
VL
SIG
I
M
G
C
LTPYATGPG
V
IIYG
C
GY
VKSK
DYWRLGAIFGVI
Y
ISM
LL
L
VG
WP
IL
A
M
W
N
fig|340184.6.peg.2546
Escherichia coli B7A
M
APL
V
V
MG
VM
F
LIP
V
P
D
G
M
PPQ
AW
H
YFAVF
V
A
M
IVG
M
ILEP
I
P
AT
AI
SF
IAVTI
CV
I
G
S
NY
LLF
DAKE
LA
D
P
A
F
NAQ
K
QA
L
K
W
G
L
A
GFSS
T
T
V
WLVF
G
AF
I
F
AL
GYE
V
S
GLGRRIAL
F
LVK
F
MG
K
RTL
T
LGYA
I
V
I
I
D
I
L
LAP
F
TPSNTAR
T
GG
T
V
F
P
V
I
K
NLPPL
FK
S
F
PND
P
S
A
RRIG
G
YLMWM
MV
I
S
T
SL
S
S
S
MF
V
T
GA
APN
V
L
G
L
EF
V
SK
I
A
G
I
--
QISW
L
Q
WFL
CF
LP
V
G
V
ILL
I
I
A
PWL
S
YVLY
K
PEI
T
HS
E
E
V
A
TWA
GD
EL
KT
MG
A
L
TR
RE
W
T
L
I
GL
V
L
L
S
L
G
LW
V
FG
SEV
--
I
N
AT
A
VG
LL
A
V
S
LML
A
--
L
H
V
V
P
WKDI
T
R
YN
S
AWNTL
V
N
LA
T
L
V
V
M
A
N
GLT
RS
GFI
D
WFA
GTMST
HL
E
G
F
SP
NA
----
TVI
VL
V
L
VFY
FA
H
Y
L
FAS
L
SA
H
T
A
T
MLPV
IL
A
V
G
KGI
P
---
G
V
P
M
EQL
C
I
L
L
VL
SIG
I
M
G
C
LTPYATGPG
V
IIYG
C
GY
VKSK
DYWRLGAIFGVI
Y
ISM
LL
L
VG
WP
IL
A
M
W
N
fig|511693.5.peg.607
Escherichia coli BL21
M
APL
V
V
MG
VM
F
LIP
V
P
D
G
M
PPQ
AW
H
YFAVF
V
A
M
IVG
M
ILEP
I
P
AT
AI
SF
IAVTI
CV
I
G
S
NY
LLF
DAKE
LA
D
P
A
F
NAQ
K
QA
L
K
W
G
L
A
GFSS
T
T
V
WLVF
G
AF
I
F
AL
GYE
V
S
GLGRRIAL
F
LVK
F
MG
K
RTL
T
LGYA
I
V
I
I
D
I
L
LAP
F
TPSNTAR
T
GG
T
V
F
P
V
I
K
NLPPL
FK
S
F
PND
P
S
A
RRIG
G
YLMWM
MV
I
S
T
SL
S
S
S
MF
V
T
GA
APN
V
L
G
L
EF
V
SK
I
A
G
I
--
QISW
L
Q
WFL
CF
LP
V
G
V
ILL
I
I
A
PWL
S
YVLY
K
PEI
T
HS
E
E
V
A
TWA
GD
EL
KT
MG
A
L
TR
RE
W
T
L
I
GL
V
L
L
S
L
G
LW
V
FG
SEV
--
I
N
AT
A
VG
LL
A
V
S
LML
A
--
L
H
V
V
P
WKDI
T
R
YN
S
AWNTL
V
N
LA
T
L
V
V
M
A
N
GLT
RS
GFI
D
WFA
GTMST
HL
E
G
F
SP
NA
----
TVI
VL
V
L
VFY
FA
H
Y
L
FAS
L
SA
H
T
A
T
MLPV
IL
A
V
G
KGI
P
---
G
V
P
M
EQL
C
I
L
L
VL
SIG
I
M
G
C
LTPYATGPG
V
IIYG
C
GY
VKSK
DYWRLGAIFGVI
Y
ISM
LL
L
VG
WP
IL
A
M
W
N
fig|469008.4.peg.3148
Escherichia coli BL21(DE3)
M
APL
V
V
MG
VM
F
LIP
V
P
D
G
M
PPQ
AW
H
YFAVF
V
A
M
IVG
M
ILEP
I
P
AT
AI
SF
IAVTI
CV
I
G
S
NY
LLF
DAKE
LA
D
P
A
F
NAQ
K
QA
L
K
W
G
L
A
GFSS
T
T
V
WLVF
G
AF
I
F
AL
GYE
V
S
GLGRRIAL
F
LVK
F
MG
K
RTL
T
LGYA
I
V
I
I
D
I
L
LAP
F
TPSNTAR
T
GG
T
V
F
P
V
I
K
NLPPL
FK
S
F
PND
P
S
A
RRIG
G
YLMWM
MV
I
S
T
SL
S
S
S
MF
V
T
GA
APN
V
L
G
L
EF
V
SK
I
A
G
I
--
QISW
L
Q
WFL
CF
LP
V
G
V
ILL
I
I
A
PWL
S
YVLY
K
PEI
T
HS
E
E
V
A
TWA
GD
EL
KT
MG
A
L
TR
RE
W
T
L
I
GL
V
L
L
S
L
G
LW
V
FG
SEV
--
I
N
AT
A
VG
LL
A
V
S
LML
A
--
L
H
V
V
P
WKDI
T
R
YN
S
AWNTL
V
N
LA
T
L
V
V
M
A
N
GLT
RS
GFI
D
WFA
GTMST
HL
E
G
F
SP
NA
----
TVI
VL
V
L
VFY
FA
H
Y
L
FAS
L
SA
H
T
A
T
MLPV
IL
A
V
G
KGI
P
---
G
V
P
M
EQL
C
I
L
L
VL
SIG
I
M
G
C
LTPYATGPG
V
IIYG
C
GY
VKSK
DYWRLGAIFGVI
Y
ISM
LL
L
VG
WP
IL
A
M
W
N
fig|595496.3.peg.538
Escherichia coli BW2952
M
APL
V
V
MG
VM
F
LIP
V
P
D
G
M
PPQ
AW
H
YFAVF
V
A
M
IVG
M
ILEP
I
P
AT
AI
SF
IAVTI
CV
I
G
S
NY
LLF
DAKE
LA
D
P
A
F
NAQ
K
QA
L
K
W
G
L
A
GFSS
T
T
V
WLVF
G
AF
I
F
AL
GYE
V
S
GLGRRIAL
F
LVK
F
MG
K
RTL
T
LGYA
I
V
I
I
D
I
L
LAP
F
TPSNTAR
T
GG
T
V
F
P
V
I
K
NLPPL
FK
S
F
PND
P
S
A
RRIG
G
YLMWM
MV
I
S
T
SL
S
S
S
MF
V
T
GA
APN
V
L
G
L
EF
V
SK
I
A
G
I
--
QISW
L
Q
WFL
CF
LP
V
G
V
ILL
I
I
A
PWL
S
YVLY
K
PEI
T
HS
E
E
V
A
TWA
GD
EL
KT
MG
A
L
TR
RE
W
T
L
I
GL
V
L
L
S
L
G
LW
V
FG
SEV
--
I
N
AT
A
VG
LL
A
V
S
LML
A
--
L
H
V
V
P
WKDI
T
R
YN
S
AWNTL
V
N
LA
T
L
V
V
M
A
N
GLT
RS
GFI
D
WFA
GTMST
HL
E
G
F
SP
NA
----
TVI
VL
V
L
VFY
FA
H
Y
L
FAS
L
SA
H
T
A
T
MLPV
IL
A
V
G
KGI
P
---
G
V
P
M
EQL
C
I
L
L
VL
SIG
I
M
G
C
LTPYATGPG
V
IIYG
C
GY
VKSK
DYWRLGAIFGVI
Y
ISM
LL
L
VG
WP
IL
A
M
W
N
fig|536056.3.peg.3185
Escherichia coli DH1
M
APL
V
V
MG
VM
F
LIP
V
P
D
G
M
PPQ
AW
H
YFAVF
V
A
M
IVG
M
ILEP
I
P
AT
AI
SF
IAVTI
CV
I
G
S
NY
LLF
DAKE
LA
D
P
A
F
NAQ
K
QA
L
K
W
G
L
A
GFSS
T
T
V
WLVF
G
AF
I
F
AL
GYE
V
S
GLGRRIAL
F
LVK
F
MG
K
RTL
T
LGYA
I
V
I
I
D
I
L
LAP
F
TPSNTAR
T
GG
T
V
F
P
V
I
K
NLPPL
FK
S
F
PND
P
S
A
RRIG
G
YLMWM
MV
I
S
T
SL
S
S
S
MF
V
T
GA
APN
V
L
G
L
EF
V
SK
I
A
G
I
--
QISW
L
Q
WFL
CF
LP
V
G
V
ILL
I
I
A
PWL
S
YVLY
K
PEI
T
HS
E
E
V
A
TWA
GD
EL
KT
MG
A
L
TR
RE
W
T
L
I
GL
V
L
L
S
L
G
LW
V
FG
SEV
--
I
N
AT
A
VG
LL
A
V
S
LML
A
--
L
H
V
V
P
WKDI
T
R
YN
S
AWNTL
V
N
LA
T
L
V
V
M
A
N
GLT
RS
GFI
D
WFA
GTMST
HL
E
G
F
SP
NA
----
TVI
VL
V
L
VFY
FA
H
Y
L
FAS
L
SA
H
T
A
T
MLPV
IL
A
V
G
KGI
P
---
G
V
P
M
EQL
C
I
L
L
VL
SIG
I
M
G
C
LTPYATGPG
V
IIYG
C
GY
VKSK
DYWRLGAIFGVI
Y
ISM
LL
L
VG
WP
IL
A
M
W
N
fig|331111.12.peg.940
Escherichia coli E24377A
M
APL
V
V
MG
VM
F
LIP
V
P
D
G
M
PPQ
AW
H
YFAVF
V
A
M
IVG
M
ILEP
I
P
AT
AI
SF
IAVTI
CV
I
G
S
NY
LLF
DAKE
LA
D
P
A
F
NAQ
K
QA
L
K
W
G
L
A
GFSS
T
T
V
WLVF
G
AF
I
F
AL
GYE
V
S
GLGRRIAL
F
LVK
F
MG
K
RTL
T
LGYA
I
V
I
I
D
I
L
LAP
F
TPSNTAR
T
GG
T
V
F
P
V
I
K
NLPPL
FK
S
F
PND
P
S
A
RRIG
G
YLMWM
MV
I
S
T
SL
S
S
S
MF
V
T
GA
APN
V
L
G
L
EF
V
SK
I
A
G
I
--
QISW
L
Q
WFL
CF
LP
V
G
V
ILL
I
I
A
PWL
S
YVLY
K
PEI
T
HS
E
E
V
A
TWA
GD
EL
KT
MG
A
L
TR
RE
W
T
L
I
GL
V
L
L
S
L
G
LW
V
FG
SEV
--
I
N
AT
A
VG
LL
A
V
S
LML
A
--
L
H
V
V
P
WKDI
T
R
YN
S
AWNTL
V
N
LA
T
L
V
V
M
A
N
GLT
RS
GFI
D
WFA
GTMST
HL
E
G
F
SP
NA
----
TVI
VL
V
L
VFY
FA
H
Y
L
FAS
L
SA
H
T
A
T
MLPV
IL
A
V
G
KGI
P
---
G
V
P
M
EQL
C
I
L
L
VL
SIG
I
M
G
C
LTPYATGPG
V
IIYG
C
GY
VKSK
DYWRLGAIFGVI
Y
ISM
LL
L
VG
WP
IL
A
M
W
N
fig|562.375.peg.1543
Escherichia coli EC4100B
M
APL
V
V
MG
VM
F
LIP
V
P
D
G
M
PPQ
AW
H
YFAVF
V
A
M
IVG
M
ILEP
I
P
AT
AI
SF
IAVTI
CV
I
G
S
NY
LLF
DAKE
LA
D
P
A
F
NAQ
K
QA
L
K
W
G
L
A
GFSS
T
T
V
WLVF
G
AF
I
F
AL
GYE
V
S
GLGRRIAL
F
LVK
F
MG
K
RTL
T
LGYA
I
V
I
I
D
I
L
LAP
F
TPSNTAR
T
GG
T
V
F
P
V
I
K
NLPPL
FK
S
F
PND
P
S
A
RRIG
G
YLMWM
MV
I
S
T
SL
S
S
S
MF
V
T
GA
APN
V
L
G
L
EF
V
SK
I
A
G
I
--
QISW
L
Q
WFL
CF
LP
V
G
V
ILL
I
I
A
PWL
S
YVLY
K
PEI
T
HS
E
E
V
A
TWA
GD
EL
KT
MG
A
L
TR
RE
W
T
L
I
GL
V
L
L
S
L
G
LW
V
FG
SEV
--
I
N
AT
A
VG
LL
A
V
S
LML
A
--
L
H
V
V
P
WKDI
T
R
YN
S
AWNTL
V
N
LA
T
L
V
V
M
A
N
GLT
RS
GFI
D
WFA
GTMST
HL
E
G
F
SP
NA
----
TVI
VL
V
L
VFY
FA
H
Y
L
FAS
L
SA
H
T
A
T
MLPV
IL
A
V
G
KGI
P
---
G
V
P
M
EQL
C
I
L
L
VL
SIG
I
M
G
C
LTPYATGPG
V
IIYG
C
GY
VKSK
DYWRLGAIFGVI
Y
ISM
LL
L
VG
WP
IL
A
M
W
N
fig|656379.3.peg.1395
Escherichia coli FVEC1302
M
APL
V
V
MG
VM
F
LIP
V
P
D
G
M
PPQ
AW
H
YFAVF
V
A
M
IVG
M
ILEP
I
P
AT
AI
SF
IAVTI
CV
I
G
S
NY
LLF
DAKE
LA
D
P
A
F
NAQ
K
QA
L
K
W
G
L
A
GFSS
T
T
V
WLVF
G
AF
I
F
AL
GYE
V
S
GLGRRIAL
F
LVK
F
MG
K
RTL
T
LGYA
I
V
I
I
D
I
L
LAP
F
TPSNTAR
T
GG
T
V
F
P
V
I
K
NLPPL
FK
S
F
PND
P
S
A
RRIG
G
YLMWM
MV
I
S
T
SL
S
S
S
MF
V
T
GA
APN
V
L
G
L
EF
V
SK
I
A
G
I
--
QISW
L
Q
WFL
CF
LP
V
G
V
ILL
I
I
A
PWL
S
YVLY
K
PEI
T
HS
E
E
V
A
TWA
GD
EL
KT
MG
A
L
TR
RE
W
T
L
I
GL
V
L
L
S
L
G
LW
V
FG
SEV
--
I
N
AT
A
VG
LL
A
V
S
LML
A
--
L
H
V
V
P
WKDI
T
R
YN
S
AWNTL
V
N
LA
T
L
V
V
M
A
N
GLT
RS
GFI
D
WFA
GTMST
HL
E
G
F
SP
NA
----
TVI
VL
V
L
VFY
FA
H
Y
L
FAS
L
SA
H
T
A
T
MLPV
IL
A
V
G
KGI
P
---
G
V
P
M
EQL
C
I
L
L
VL
SIG
I
M
G
C
LTPYATGPG
V
IIYG
C
GY
VKSK
DYWRLGAIFGVI
Y
ISM
LL
L
VG
WP
IL
A
M
W
N
fig|656380.3.peg.1222
Escherichia coli FVEC1412
M
APL
V
V
MG
VM
F
LIP
V
P
D
G
M
PPQ
AW
H
YFAVF
V
A
M
IVG
M
ILEP
I
P
AT
AI
SF
IAVTI
CV
I
G
S
NY
LLF
DAKE
LA
D
P
A
F
NAQ
K
QA
L
K
W
G
L
A
GFSS
T
T
V
WLVF
G
AF
I
F
AL
GYE
V
S
GLGRRIAL
F
LVK
F
MG
K
RTL
T
LGYA
I
V
I
I
D
I
L
LAP
F
TPSNTAR
T
GG
T
V
F
P
V
I
K
NLPPL
FK
S
F
PND
P
S
A
RRIG
G
YLMWM
MV
I
S
T
SL
S
S
S
MF
V
T
GA
APN
V
L
G
L
EF
V
SK
I
A
G
I
--
QISW
L
Q
WFL
CF
LP
V
G
V
ILL
I
I
A
PWL
S
YVLY
K
PEI
T
HS
E
E
V
A
TWA
GD
EL
KT
MG
A
L
TR
RE
W
T
L
I
GL
V
L
L
S
L
G
LW
V
FG
SEV
--
I
N
AT
A
VG
LL
A
V
S
LML
A
--
L
H
V
V
P
WKDI
T
R
YN
S
AWNTL
V
N
LA
T
L
V
V
M
A
N
GLT
RS
GFI
D
WFA
GTMST
HL
E
G
F
SP
NA
----
TVI
VL
V
L
VFY
FA
H
Y
L
FAS
L
SA
H
T
A
T
MLPV
IL
A
V
G
KGI
P
---
G
V
P
M
EQL
C
I
L
L
VL
SIG
I
M
G
C
LTPYATGPG
V
IIYG
C
GY
VKSK
DYWRLGAIFGVI
Y
ISM
LL
L
VG
WP
IL
A
M
W
N
fig|656408.3.peg.549
Escherichia coli H591
M
APL
V
V
MG
VM
F
LIP
V
P
D
G
M
PPQ
AW
H
YFAVF
V
A
M
IVG
M
ILEP
I
P
AT
AI
SF
IAVTI
CV
I
G
S
NY
LLF
DAKE
LA
D
P
A
F
NAQ
K
QA
L
K
W
G
L
A
GFSS
T
T
V
WLVF
G
AF
I
F
AL
GYE
V
S
GLGRRIAL
F
LVK
F
MG
K
RTL
T
LGYA
I
V
I
I
D
I
L
LAP
F
TPSNTAR
T
GG
T
V
F
P
V
I
K
NLPPL
FK
S
F
PND
P
S
A
RRIG
G
YLMWM
MV
I
S
T
SL
S
S
S
MF
V
T
GA
APN
V
L
G
L
EF
V
SK
I
A
G
I
--
QISW
L
Q
WFL
CF
LP
V
G
V
ILL
I
I
A
PWL
S
YVLY
K
PEI
T
HS
E
E
V
A
TWA
GD
EL
KT
MG
A
L
TR
RE
W
T
L
I
GL
V
L
L
S
L
G
LW
V
FG
SEV
--
I
N
AT
A
VG
LL
A
V
S
LML
A
--
L
H
V
V
P
WKDI
T
R
YN
S
AWNTL
V
N
LA
T
L
V
V
M
A
N
GLT
RS
GFI
D
WFA
GTMST
HL
E
G
F
SP
NA
----
TVI
VL
V
L
VFY
FA
H
Y
L
FAS
L
SA
H
T
A
T
MLPV
IL
A
V
G
KGI
P
---
G
V
P
M
EQL
C
I
L
L
VL
SIG
I
M
G
C
LTPYATGPG
V
IIYG
C
GY
VKSK
DYWRLGAIFGVI
Y
ISM
LL
L
VG
WP
IL
A
M
W
N
fig|656414.3.peg.790
Escherichia coli H736
M
APL
V
V
MG
VM
F
LIP
V
P
D
G
M
PPQ
AW
H
YFAVF
V
A
M
IVG
M
ILEP
I
P
AT
AI
SF
IAVTI
CV
I
G
S
NY
LLF
DAKE
LA
D
P
A
F
NAQ
K
QA
L
K
W
G
L
A
GFSS
T
T
V
WLVF
G
AF
I
F
AL
GYE
V
S
GLGRRIAL
F
LVK
F
MG
K
RTL
T
LGYA
I
V
I
I
D
I
L
LAP
F
TPSNTAR
T
GG
T
V
F
P
V
I
K
NLPPL
FK
S
F
PND
P
S
A
RRIG
G
YLMWM
MV
I
S
T
SL
S
S
S
MF
V
T
GA
APN
V
L
G
L
EF
V
SK
I
A
G
I
--
QISW
L
Q
WFL
CF
LP
V
G
V
ILL
I
I
A
PWL
S
YVLY
K
PEI
T
HS
E
E
V
A
TWA
GD
EL
KT
MG
A
L
TR
RE
W
T
L
I
GL
V
L
L
S
L
G
LW
V
FG
SEV
--
I
N
AT
A
VG
LL
A
V
S
LML
A
--
L
H
V
V
P
WKDI
T
R
YN
S
AWNTL
V
N
LA
T
L
V
V
M
A
N
GLT
RS
GFI
D
WFA
GTMST
HL
E
G
F
SP
NA
----
TVI
VL
V
L
VFY
FA
H
Y
L
FAS
L
SA
H
T
A
T
MLPV
IL
A
V
G
KGI
P
---
G
V
P
M
EQL
C
I
L
L
VL
SIG
I
M
G
C
LTPYATGPG
V
IIYG
C
GY
VKSK
DYWRLGAIFGVI
Y
ISM
LL
L
VG
WP
IL
A
M
W
N
fig|331112.6.peg.648
Escherichia coli HS
M
APL
V
V
MG
VM
F
LIP
V
P
D
G
M
PPQ
AW
H
YFAVF
V
A
M
IVG
M
ILEP
I
P
AT
AI
SF
IAVTI
CV
I
G
S
NY
LLF
DAKE
LA
D
P
A
F
NAQ
K
QA
L
K
W
G
L
A
GFSS
T
T
V
WLVF
G
AF
I
F
AL
GYE
V
S
GLGRRIAL
F
LVK
F
MG
K
RTL
T
LGYA
I
V
I
I
D
I
L
LAP
F
TPSNTAR
T
GG
T
V
F
P
V
I
K
NLPPL
FK
S
F
PND
P
S
A
RRIG
G
YLMWM
MV
I
S
T
SL
S
S
S
MF
V
T
GA
APN
V
L
G
L
EF
V
SK
I
A
G
I
--
QISW
L
Q
WFL
CF
LP
V
G
V
ILL
I
I
A
PWL
S
YVLY
K
PEI
T
HS
E
E
V
A
TWA
GD
EL
KT
MG
A
L
TR
RE
W
T
L
I
GL
V
L
L
S
L
G
LW
V
FG
SEV
--
I
N
AT
A
VG
LL
A
V
S
LML
A
--
L
H
V
V
P
WKDI
T
R
YN
S
AWNTL
V
N
LA
T
L
V
V
M
A
N
GLT
RS
GFI
D
WFA
GTMST
HL
E
G
F
SP
NA
----
TVI
VL
V
L
VFY
FA
H
Y
L
FAS
L
SA
H
T
A
T
MLPV
IL
A
V
G
KGI
P
---
G
V
P
M
EQL
C
I
L
L
VL
SIG
I
M
G
C
LTPYATGPG
V
IIYG
C
GY
VKSK
DYWRLGAIFGVI
Y
ISM
LL
L
VG
WP
IL
A
M
W
N
fig|585034.4.peg.591
Escherichia coli IAI1
M
APL
V
V
MG
VM
F
LIP
V
P
D
G
M
PPQ
AW
H
YFAVF
V
A
M
IVG
M
ILEP
I
P
AT
AI
SF
IAVTI
CV
I
G
S
NY
LLF
DAKE
LA
D
P
A
F
NAQ
K
QA
L
K
W
G
L
A
GFSS
T
T
V
WLVF
G
AF
I
F
AL
GYE
V
S
GLGRRIAL
F
LVK
F
MG
K
RTL
T
LGYA
I
V
I
I
D
I
L
LAP
F
TPSNTAR
T
GG
T
V
F
P
V
I
K
NLPPL
FK
S
F
PND
P
S
A
RRIG
G
YLMWM
MV
I
S
T
SL
S
S
S
MF
V
T
GA
APN
V
L
G
L
EF
V
SK
I
A
G
I
--
QISW
L
Q
WFL
CF
LP
V
G
V
ILL
I
I
A
PWL
S
YVLY
K
PEI
T
HS
E
E
V
A
TWA
GD
EL
KT
MG
A
L
TR
RE
W
T
L
I
GL
V
L
L
S
L
G
LW
V
FG
SEV
--
I
N
AT
A
VG
LL
A
V
S
LML
A
--
L
H
V
V
P
WKDI
T
R
YN
S
AWNTL
V
N
LA
T
L
V
V
M
A
N
GLT
RS
GFI
D
WFA
GTMST
HL
E
G
F
SP
NA
----
TVI
VL
V
L
VFY
FA
H
Y
L
FAS
L
SA
H
T
A
T
MLPV
IL
A
V
G
KGI
P
---
G
V
P
M
EQL
C
I
L
L
VL
SIG
I
M
G
C
LTPYATGPG
V
IIYG
C
GY
VKSK
DYWRLGAIFGVI
Y
ISM
LL
L
VG
WP
IL
A
M
W
N
fig|585034.5.peg.590
Escherichia coli IAI1
M
APL
V
V
MG
VM
F
LIP
V
P
D
G
M
PPQ
AW
H
YFAVF
V
A
M
IVG
M
ILEP
I
P
AT
AI
SF
IAVTI
CV
I
G
S
NY
LLF
DAKE
LA
D
P
A
F
NAQ
K
QA
L
K
W
G
L
A
GFSS
T
T
V
WLVF
G
AF
I
F
AL
GYE
V
S
GLGRRIAL
F
LVK
F
MG
K
RTL
T
LGYA
I
V
I
I
D
I
L
LAP
F
TPSNTAR
T
GG
T
V
F
P
V
I
K
NLPPL
FK
S
F
PND
P
S
A
RRIG
G
YLMWM
MV
I
S
T
SL
S
S
S
MF
V
T
GA
APN
V
L
G
L
EF
V
SK
I
A
G
I
--
QISW
L
Q
WFL
CF
LP
V
G
V
ILL
I
I
A
PWL
S
YVLY
K
PEI
T
HS
E
E
V
A
TWA
GD
EL
KT
MG
A
L
TR
RE
W
T
L
I
GL
V
L
L
S
L
G
LW
V
FG
SEV
--
I
N
AT
A
VG
LL
A
V
S
LML
A
--
L
H
V
V
P
WKDI
T
R
YN
S
AWNTL
V
N
LA
T
L
V
V
M
A
N
GLT
RS
GFI
D
WFA
GTMST
HL
E
G
F
SP
NA
----
TVI
VL
V
L
VFY
FA
H
Y
L
FAS
L
SA
H
T
A
T
MLPV
IL
A
V
G
KGI
P
---
G
V
P
M
EQL
C
I
L
L
VL
SIG
I
M
G
C
LTPYATGPG
V
IIYG
C
GY
VKSK
DYWRLGAIFGVI
Y
ISM
LL
L
VG
WP
IL
A
M
W
N
fig|595495.4.peg.2000
Escherichia coli KO11
M
APL
V
V
MG
VM
F
LIP
V
P
D
G
M
PPQ
AW
H
YFAVF
V
A
M
IVG
M
ILEP
I
P
AT
AI
SF
IAVTI
CV
I
G
S
NY
LLF
DAKE
LA
D
P
A
F
NAQ
K
QA
L
K
W
G
L
A
GFSS
T
T
V
WLVF
G
AF
I
F
AL
GYE
V
S
GLGRRIAL
F
LVK
F
MG
K
RTL
T
LGYA
I
V
I
I
D
I
L
LAP
F
TPSNTAR
T
GG
T
V
F
P
V
I
K
NLPPL
FK
S
F
PND
P
S
A
RRIG
G
YLMWM
MV
I
S
T
SL
S
S
S
MF
V
T
GA
APN
V
L
G
L
EF
V
SK
I
A
G
I
--
QISW
L
Q
WFL
CF
LP
V
G
V
ILL
I
I
A
PWL
S
YVLY
K
PEI
T
HS
E
E
V
A
TWA
GD
EL
KT
MG
A
L
TR
RE
W
T
L
I
GL
V
L
L
S
L
G
LW
V
FG
SEV
--
I
N
AT
A
VG
LL
A
V
S
LML
A
--
L
H
V
V
P
WKDI
T
R
YN
S
AWNTL
V
N
LA
T
L
V
V
M
A
N
GLT
RS
GFI
D
WFA
GTMST
HL
E
G
F
SP
NA
----
TVI
VL
V
L
VFY
FA
H
Y
L
FAS
L
SA
H
T
A
T
MLPV
IL
A
V
G
KGI
P
---
G
V
P
M
EQL
C
I
L
L
VL
SIG
I
M
G
C
LTPYATGPG
V
IIYG
C
GY
VKSK
DYWRLGAIFGVI
Y
ISM
LL
L
VG
WP
IL
A
M
W
N
fig|749537.3.peg.4047
Escherichia coli MS 115-1
M
APL
V
V
MG
VM
F
LIP
V
P
D
G
M
PPQ
AW
H
YFAVF
V
A
M
IVG
M
ILEP
I
P
AT
AI
SF
IAVTI
CV
I
G
S
NY
LLF
DAKE
LA
D
P
A
F
NAQ
K
QA
L
K
W
G
L
A
GFSS
T
T
V
WLVF
G
AF
I
F
AL
GYE
V
S
GLGRRIAL
F
LVK
F
MG
K
RTL
T
LGYA
I
V
I
I
D
I
L
LAP
F
TPSNTAR
T
GG
T
V
F
P
V
I
K
NLPPL
FK
S
F
PND
P
S
A
RRIG
G
YLMWM
MV
I
S
T
SL
S
S
S
MF
V
T
GA
APN
V
L
G
L
EF
V
SK
I
A
G
I
--
QISW
L
Q
WFL
CF
LP
V
G
V
ILL
I
I
A
PWL
S
YVLY
K
PEI
T
HS
E
E
V
A
TWA
GD
EL
KT
MG
A
L
TR
RE
W
T
L
I
GL
V
L
L
S
L
G
LW
V
FG
SEV
--
I
N
AT
A
VG
LL
A
V
S
LML
A
--
L
H
V
V
P
WKDI
T
R
YN
S
AWNTL
V
N
LA
T
L
V
V
M
A
N
GLT
RS
GFI
D
WFA
GTMST
HL
E
G
F
SP
NA
----
TVI
VL
V
L
VFY
FA
H
Y
L
FAS
L
SA
H
T
A
T
MLPV
IL
A
V
G
KGI
P
---
G
V
P
M
EQL
C
I
L
L
VL
SIG
I
M
G
C
LTPYATGPG
V
IIYG
C
GY
VKSK
DYWRLGAIFGVI
Y
ISM
LL
L
VG
WP
IL
A
M
W
N
fig|749538.3.peg.4222
Escherichia coli MS 116-1
M
APL
V
V
MG
VM
F
LIP
V
P
D
G
M
PPQ
AW
H
YFAVF
V
A
M
IVG
M
ILEP
I
P
AT
AI
SF
IAVTI
CV
I
G
S
NY
LLF
DAKE
LA
D
P
A
F
NAQ
K
QA
L
K
W
G
L
A
GFSS
T
T
V
WLVF
G
AF
I
F
AL
GYE
V
S
GLGRRIAL
F
LVK
F
MG
K
RTL
T
LGYA
I
V
I
I
D
I
L
LAP
F
TPSNTAR
T
GG
T
V
F
P
V
I
K
NLPPL
FK
S
F
PND
P
S
A
RRIG
G
YLMWM
MV
I
S
T
SL
S
S
S
MF
V
T
GA
APN
V
L
G
L
EF
V
SK
I
A
G
I
--
QISW
L
Q
WFL
CF
LP
V
G
V
ILL
I
I
A
PWL
S
YVLY
K
PEI
T
HS
E
E
V
A
TWA
GD
EL
KT
MG
A
L
TR
RE
W
T
L
I
GL
V
L
L
S
L
G
LW
V
FG
SEV
--
I
N
AT
A
VG
LL
A
V
S
LML
A
--
L
H
V
V
P
WKDI
T
R
YN
S
AWNTL
V
N
LA
T
L
V
V
M
A
N
GLT
RS
GFI
D
WFA
GTMST
HL
E
G
F
SP
NA
----
TVI
VL
V
L
VFY
FA
H
Y
L
FAS
L
SA
H
T
A
T
MLPV
IL
A
V
G
KGI
P
---
G
V
P
M
EQL
C
I
L
L
VL
SIG
I
M
G
C
LTPYATGPG
V
IIYG
C
GY
VKSK
DYWRLGAIFGVI
Y
ISM
LL
L
VG
WP
IL
A
M
W
N
fig|679206.4.peg.2854
Escherichia coli MS 119-7
M
APL
V
V
MG
VM
F
LIP
V
P
D
G
M
PPQ
AW
H
YFAVF
V
A
M
IVG
M
ILEP
I
P
AT
AI
SF
IAVTI
CV
I
G
S
NY
LLF
DAKE
LA
D
P
A
F
NAQ
K
QA
L
K
W
G
L
A
GFSS
T
T
V
WLVF
G
AF
I
F
AL
GYE
V
S
GLGRRIAL
F
LVK
F
MG
K
RTL
T
LGYA
I
V
I
I
D
I
L
LAP
F
TPSNTAR
T
GG
T
V
F
P
V
I
K
NLPPL
FK
S
F
PND
P
S
A
RRIG
G
YLMWM
MV
I
S
T
SL
S
S
S
MF
V
T
GA
APN
V
L
G
L
EF
V
SK
I
A
G
I
--
QISW
L
Q
WFL
CF
LP
V
G
V
ILL
I
I
A
PWL
S
YVLY
K
PEI
T
HS
E
E
V
A
TWA
GD
EL
KT
MG
A
L
TR
RE
W
T
L
I
GL
V
L
L
S
L
G
LW
V
FG
SEV
--
I
N
AT
A
VG
LL
A
V
S
LML
A
--
L
H
V
V
P
WKDI
T
R
YN
S
AWNTL
V
N
LA
T
L
V
V
M
A
N
GLT
RS
GFI
D
WFA
GTMST
HL
E
G
F
SP
NA
----
TVI
VL
V
L
VFY
FA
H
Y
L
FAS
L
SA
H
T
A
T
MLPV
IL
A
V
G
KGI
P
---
G
V
P
M
EQL
C
I
L
L
VL
SIG
I
M
G
C
LTPYATGPG
V
IIYG
C
GY
VKSK
DYWRLGAIFGVI
Y
ISM
LL
L
VG
WP
IL
A
M
W
N
fig|679205.4.peg.619
Escherichia coli MS 124-1
M
APL
V
V
MG
VM
F
LIP
V
P
D
G
M
PPQ
AW
H
YFAVF
V
A
M
IVG
M
ILEP
I
P
AT
AI
SF
IAVTI
CV
I
G
S
NY
LLF
DAKE
LA
D
P
A
F
NAQ
K
QA
L
K
W
G
L
A
GFSS
T
T
V
WLVF
G
AF
I
F
AL
GYE
V
S
GLGRRIAL
F
LVK
F
MG
K
RTL
T
LGYA
I
V
I
I
D
I
L
LAP
F
TPSNTAR
T
GG
T
V
F
P
V
I
K
NLPPL
FK
S
F
PND
P
S
A
RRIG
G
YLMWM
MV
I
S
T
SL
S
S
S
MF
V
T
GA
APN
V
L
G
L
EF
V
SK
I
A
G
I
--
QISW
L
Q
WFL
CF
LP
V
G
V
ILL
I
I
A
PWL
S
YVLY
K
PEI
T
HS
E
E
V
A
TWA
GD
EL
KT
MG
A
L
TR
RE
W
T
L
I
GL
V
L
L
S
L
G
LW
V
FG
SEV
--
I
N
AT
A
VG
LL
A
V
S
LML
A
--
L
H
V
V
P
WKDI
T
R
YN
S
AWNTL
V
N
LA
T
L
V
V
M
A
N
GLT
RS
GFI
D
WFA
GTMST
HL
E
G
F
SP
NA
----
TVI
VL
V
L
VFY
FA
H
Y
L
FAS
L
SA
H
T
A
T
MLPV
IL
A
V
G
KGI
P
---
G
V
P
M
EQL
C
I
L
L
VL
SIG
I
M
G
C
LTPYATGPG
V
IIYG
C
GY
VKSK
DYWRLGAIFGVI
Y
ISM
LL
L
VG
WP
IL
A
M
W
N
fig|749540.3.peg.624
Escherichia coli MS 146-1
M
APL
V
V
MG
VM
F
LIP
V
P
D
G
M
PPQ
AW
H
YFAVF
V
A
M
IVG
M
ILEP
I
P
AT
AI
SF
IAVTI
CV
I
G
S
NY
LLF
DAKE
LA
D
P
A
F
NAQ
K
QA
L
K
W
G
L
A
GFSS
T
T
V
WLVF
G
AF
I
F
AL
GYE
V
S
GLGRRIAL
F
LVK
F
MG
K
RTL
T
LGYA
I
V
I
I
D
I
L
LAP
F
TPSNTAR
T
GG
T
V
F
P
V
I
K
NLPPL
FK
S
F
PND
P
S
A
RRIG
G
YLMWM
MV
I
S
T
SL
S
S
S
MF
V
T
GA
APN
V
L
G
L
EF
V
SK
I
A
G
I
--
QISW
L
Q
WFL
CF
LP
V
G
V
ILL
I
I
A
PWL
S
YVLY
K
PEI
T
HS
E
E
V
A
TWA
GD
EL
KT
MG
A
L
TR
RE
W
T
L
I
GL
V
L
L
S
L
G
LW
V
FG
SEV
--
I
N
AT
A
VG
LL
A
V
S
LML
A
--
L
H
V
V
P
WKDI
T
R
YN
S
AWNTL
V
N
LA
T
L
V
V
M
A
N
GLT
RS
GFI
D
WFA
GTMST
HL
E
G
F
SP
NA
----
TVI
VL
V
L
VFY
FA
H
Y
L
FAS
L
SA
H
T
A
T
MLPV
IL
A
V
G
KGI
P
---
G
V
P
M
EQL
C
I
L
L
VL
SIG
I
M
G
C
LTPYATGPG
V
IIYG
C
GY
VKSK
DYWRLGAIFGVI
Y
ISM
LL
L
VG
WP
IL
A
M
W
N
fig|749545.3.peg.5021
Escherichia coli MS 182-1
M
APL
V
V
MG
VM
F
LIP
V
P
D
G
M
PPQ
AW
H
YFAVF
V
A
M
IVG
M
ILEP
I
P
AT
AI
SF
IAVTI
CV
I
G
S
NY
LLF
DAKE
LA
D
P
A
F
NAQ
K
QA
L
K
W
G
L
A
GFSS
T
T
V
WLVF
G
AF
I
F
AL
GYE
V
S
GLGRRIAL
F
LVK
F
MG
K
RTL
T
LGYA
I
V
I
I
D
I
L
LAP
F
TPSNTAR
T
GG
T
V
F
P
V
I
K
NLPPL
FK
S
F
PND
P
S
A
RRIG
G
YLMWM
MV
I
S
T
SL
S
S
S
MF
V
T
GA
APN
V
L
G
L
EF
V
SK
I
A
G
I
--
QISW
L
Q
WFL
CF
LP
V
G
V
ILL
I
I
A
PWL
S
YVLY
K
PEI
T
HS
E
E
V
A
TWA
GD
EL
KT
MG
A
L
TR
RE
W
T
L
I
GL
V
L
L
S
L
G
LW
V
FG
SEV
--
I
N
AT
A
VG
LL
A
V
S
LML
A
--
L
H
V
V
P
WKDI
T
R
YN
S
AWNTL
V
N
LA
T
L
V
V
M
A
N
GLT
RS
GFI
D
WFA
GTMST
HL
E
G
F
SP
NA
----
TVI
VL
V
L
VFY
FA
H
Y
L
FAS
L
SA
H
T
A
T
MLPV
IL
A
V
G
KGI
P
---
G
V
P
M
EQL
C
I
L
L
VL
SIG
I
M
G
C
LTPYATGPG
V
IIYG
C
GY
VKSK
DYWRLGAIFGVI
Y
ISM
LL
L
VG
WP
IL
A
M
W
N
fig|749547.3.peg.3608
Escherichia coli MS 187-1
M
APL
V
V
MG
VM
F
LIP
V
P
D
G
M
PPQ
AW
H
YFAVF
V
A
M
IVG
M
ILEP
I
P
AT
AI
SF
IAVTI
CV
I
G
S
NY
LLF
DAKE
LA
D
P
A
F
NAQ
K
QA
L
K
W
G
L
A
GFSS
T
T
V
WLVF
G
AF
I
F
AL
GYE
V
S
GLGRRIAL
F
LVK
F
MG
K
RTL
T
LGYA
I
V
I
I
D
I
L
LAP
F
TPSNTAR
T
GG
T
V
F
P
V
I
K
NLPPL
FK
S
F
PND
P
S
A
RRIG
G
YLMWM
MV
I
S
T
SL
S
S
S
MF
V
T
GA
APN
V
L
G
L
EF
V
SK
I
A
G
I
--
QISW
L
Q
WFL
CF
LP
V
G
V
ILL
I
I
A
PWL
S
YVLY
K
PEI
T
HS
E
E
V
A
TWA
GD
EL
KT
MG
A
L
TR
RE
W
T
L
I
GL
V
L
L
S
L
G
LW
V
FG
SEV
--
I
N
AT
A
VG
LL
A
V
S
LML
A
--
L
H
V
V
P
WKDI
T
R
YN
S
AWNTL
V
N
LA
T
L
V
V
M
A
N
GLT
RS
GFI
D
WFA
GTMST
HL
E
G
F
SP
NA
----
TVI
VL
V
L
VFY
FA
H
Y
L
FAS
L
SA
H
T
A
T
MLPV
IL
A
V
G
KGI
P
---
G
V
P
M
EQL
C
I
L
L
VL
SIG
I
M
G
C
LTPYATGPG
V
IIYG
C
GY
VKSK
DYWRLGAIFGVI
Y
ISM
LL
L
VG
WP
IL
A
M
W
N
fig|749548.3.peg.4518
Escherichia coli MS 196-1
M
APL
V
V
MG
VM
F
LIP
V
P
D
G
M
PPQ
AW
H
YFAVF
V
A
M
IVG
M
ILEP
I
P
AT
AI
SF
IAVTI
CV
I
G
S
NY
LLF
DAKE
LA
D
P
A
F
NAQ
K
QA
L
K
W
G
L
A
GFSS
T
T
V
WLVF
G
AF
I
F
AL
GYE
V
S
GLGRRIAL
F
LVK
F
MG
K
RTL
T
LGYA
I
V
I
I
D
I
L
LAP
F
TPSNTAR
T
GG
T
V
F
P
V
I
K
NLPPL
FK
S
F
PND
P
S
A
RRIG
G
YLMWM
MV
I
S
T
SL
S
S
S
MF
V
T
GA
APN
V
L
G
L
EF
V
SK
I
A
G
I
--
QISW
L
Q
WFL
CF
LP
V
G
V
ILL
I
I
A
PWL
S
YVLY
K
PEI
T
HS
E
E
V
A
TWA
GD
EL
KT
MG
A
L
TR
RE
W
T
L
I
GL
V
L
L
S
L
G
LW
V
FG
SEV
--
I
N
AT
A
VG
LL
A
V
S
LML
A
--
L
H
V
V
P
WKDI
T
R
YN
S
AWNTL
V
N
LA
T
L
V
V
M
A
N
GLT
RS
GFI
D
WFA
GTMST
HL
E
G
F
SP
NA
----
TVI
VL
V
L
VFY
FA
H
Y
L
FAS
L
SA
H
T
A
T
MLPV
IL
A
V
G
KGI
P
---
G
V
P
M
EQL
C
I
L
L
VL
SIG
I
M
G
C
LTPYATGPG
V
IIYG
C
GY
VKSK
DYWRLGAIFGVI
Y
ISM
LL
L
VG
WP
IL
A
M
W
N
fig|749549.3.peg.4877
Escherichia coli MS 198-1
M
APL
V
V
MG
VM
F
LIP
V
P
D
G
M
PPQ
AW
H
YFAVF
V
A
M
IVG
M
ILEP
I
P
AT
AI
SF
IAVTI
CV
I
G
S
NY
LLF
DAKE
LA
D
P
A
F
NAQ
K
QA
L
K
W
G
L
A
GFSS
T
T
V
WLVF
G
AF
I
F
AL
GYE
V
S
GLGRRIAL
F
LVK
F
MG
K
RTL
T
LGYA
I
V
I
I
D
I
L
LAP
F
TPSNTAR
T
GG
T
V
F
P
V
I
K
NLPPL
FK
S
F
PND
P
S
A
RRIG
G
YLMWM
MV
I
S
T
SL
S
S
S
MF
V
T
GA
APN
V
L
G
L
EF
V
SK
I
A
G
I
--
QISW
L
Q
WFL
CF
LP
V
G
V
ILL
I
I
A
PWL
S
YVLY
K
PEI
T
HS
E
E
V
A
TWA
GD
EL
KT
MG
A
L
TR
RE
W
T
L
I
GL
V
L
L
S
L
G
LW
V
FG
SEV
--
I
N
AT
A
VG
LL
A
V
S
LML
A
--
L
H
V
V
P
WKDI
T
R
YN
S
AWNTL
V
N
LA
T
L
V
V
M
A
N
GLT
RS
GFI
D
WFA
GTMST
HL
E
G
F
SP
NA
----
TVI
VL
V
L
VFY
FA
H
Y
L
FAS
L
SA
H
T
A
T
MLPV
IL
A
V
G
KGI
P
---
G
V
P
M
EQL
C
I
L
L
VL
SIG
I
M
G
C
LTPYATGPG
V
IIYG
C
GY
VKSK
DYWRLGAIFGVI
Y
ISM
LL
L
VG
WP
IL
A
M
W
N
fig|749531.3.peg.4091
Escherichia coli MS 69-1
M
APL
V
V
MG
VM
F
LIP
V
P
D
G
M
PPQ
AW
H
YFAVF
V
A
M
IVG
M
ILEP
I
P
AT
AI
SF
IAVTI
CV
I
G
S
NY
LLF
DAKE
LA
D
P
A
F
NAQ
K
QA
L
K
W
G
L
A
GFSS
T
T
V
WLVF
G
AF
I
F
AL
GYE
V
S
GLGRRIAL
F
LVK
F
MG
K
RTL
T
LGYA
I
V
I
I
D
I
L
LAP
F
TPSNTAR
T
GG
T
V
F
P
V
I
K
NLPPL
FK
S
F
PND
P
S
A
RRIG
G
YLMWM
MV
I
S
T
SL
S
S
S
MF
V
T
GA
APN
V
L
G
L
EF
V
SK
I
A
G
I
--
QISW
L
Q
WFL
CF
LP
V
G
V
ILL
I
I
A
PWL
S
YVLY
K
PEI
T
HS
E
E
V
A
TWA
GD
EL
KT
MG
A
L
TR
RE
W
T
L
I
GL
V
L
L
S
L
G
LW
V
FG
SEV
--
I
N
AT
A
VG
LL
A
V
S
LML
A
--
L
H
V
V
P
WKDI
T
R
YN
S
AWNTL
V
N
LA
T
L
V
V
M
A
N
GLT
RS
GFI
D
WFA
GTMST
HL
E
G
F
SP
NA
----
TVI
VL
V
L
VFY
FA
H
Y
L
FAS
L
SA
H
T
A
T
MLPV
IL
A
V
G
KGI
P
---
G
V
P
M
EQL
C
I
L
L
VL
SIG
I
M
G
C
LTPYATGPG
V
IIYG
C
GY
VKSK
DYWRLGAIFGVI
Y
ISM
LL
L
VG
WP
IL
A
M
W
N
fig|749532.3.peg.3687
Escherichia coli MS 78-1
M
APL
V
V
MG
VM
F
LIP
V
P
D
G
M
PPQ
AW
H
YFAVF
V
A
M
IVG
M
ILEP
I
P
AT
AI
SF
IAVTI
CV
I
G
S
NY
LLF
DAKE
LA
D
P
A
F
NAQ
K
QA
L
K
W
G
L
A
GFSS
T
T
V
WLVF
G
AF
I
F
AL
GYE
V
S
GLGRRIAL
F
LVK
F
MG
K
RTL
T
LGYA
I
V
I
I
D
I
L
LAP
F
TPSNTAR
T
GG
T
V
F
P
V
I
K
NLPPL
FK
S
F
PND
P
S
A
RRIG
G
YLMWM
MV
I
S
T
SL
S
S
S
MF
V
T
GA
APN
V
L
G
L
EF
V
SK
I
A
G
I
--
QISW
L
Q
WFL
CF
LP
V
G
V
ILL
I
I
A
PWL
S
YVLY
K
PEI
T
HS
E
E
V
A
TWA
GD
EL
KT
MG
A
L
TR
RE
W
T
L
I
GL
V
L
L
S
L
G
LW
V
FG
SEV
--
I
N
AT
A
VG
LL
A
V
S
LML
A
--
L
H
V
V
P
WKDI
T
R
YN
S
AWNTL
V
N
LA
T
L
V
V
M
A
N
GLT
RS
GFI
D
WFA
GTMST
HL
E
G
F
SP
NA
----
TVI
VL
V
L
VFY
FA
H
Y
L
FAS
L
SA
H
T
A
T
MLPV
IL
A
V
G
KGI
P
---
G
V
P
M
EQL
C
I
L
L
VL
SIG
I
M
G
C
LTPYATGPG
V
IIYG
C
GY
VKSK
DYWRLGAIFGVI
Y
ISM
LL
L
VG
WP
IL
A
M
W
N
fig|585395.4.peg.651
Escherichia coli O103:H2 str. 12009
M
APL
V
V
MG
VM
F
LIP
V
P
D
G
M
PPQ
AW
H
YFAVF
V
A
M
IVG
M
ILEP
I
P
AT
AI
SF
IAVTI
CV
I
G
S
NY
LLF
DAKE
LA
D
P
A
F
NAQ
K
QA
L
K
W
G
L
A
GFSS
T
T
V
WLVF
G
AF
I
F
AL
GYE
V
S
GLGRRIAL
F
LVK
F
MG
K
RTL
T
LGYA
I
V
I
I
D
I
L
LAP
F
TPSNTAR
T
GG
T
V
F
P
V
I
K
NLPPL
FK
S
F
PND
P
S
A
RRIG
G
YLMWM
MV
I
S
T
SL
S
S
S
MF
V
T
GA
APN
V
L
G
L
EF
V
SK
I
A
G
I
--
QISW
L
Q
WFL
CF
LP
V
G
V
ILL
I
I
A
PWL
S
YVLY
K
PEI
T
HS
E
E
V
A
TWA
GD
EL
KT
MG
A
L
TR
RE
W
T
L
I
GL
V
L
L
S
L
G
LW
V
FG
SEV
--
I
N
AT
A
VG
LL
A
V
S
LML
A
--
L
H
V
V
P
WKDI
T
R
YN
S
AWNTL
V
N
LA
T
L
V
V
M
A
N
GLT
RS
GFI
D
WFA
GTMST
HL
E
G
F
SP
NA
----
TVI
VL
V
L
VFY
FA
H
Y
L
FAS
L
SA
H
T
A
T
MLPV
IL
A
V
G
KGI
P
---
G
V
P
M
EQL
C
I
L
L
VL
SIG
I
M
G
C
LTPYATGPG
V
IIYG
C
GY
VKSK
DYWRLGAIFGVI
Y
ISM
LL
L
VG
WP
IL
A
M
W
N
fig|444454.5.peg.5139
Escherichia coli O157:H7 str. EC4024
M
APL
V
V
MG
VM
F
LIP
V
P
D
G
M
PPQ
AW
H
YFAVF
V
A
M
IVG
M
ILEP
I
P
AT
AI
SF
IAVTI
CV
I
G
S
NY
LLF
DAKE
LA
D
P
A
F
NAQ
K
QA
L
K
W
G
L
A
GFSS
T
T
V
WLVF
G
AF
I
F
AL
GYE
V
S
GLGRRIAL
F
LVK
F
MG
K
RTL
T
LGYA
I
V
I
I
D
I
L
LAP
F
TPSNTAR
T
GG
T
V
F
P
V
I
K
NLPPL
FK
S
F
PND
P
S
A
RRIG
G
YLMWM
MV
I
S
T
SL
S
S
S
MF
V
T
GA
APN
V
L
G
L
EF
V
SK
I
A
G
I
--
QISW
L
Q
WFL
CF
LP
V
G
V
ILL
I
I
A
PWL
S
YVLY
K
PEI
T
HS
E
E
V
A
TWA
GD
EL
KT
MG
A
L
TR
RE
W
T
L
I
GL
V
L
L
S
L
G
LW
V
FG
SEV
--
I
N
AT
A
VG
LL
A
V
S
LML
A
--
L
H
V
V
P
WKDI
T
R
YN
S
AWNTL
V
N
LA
T
L
V
V
M
A
N
GLT
RS
GFI
D
WFA
GTMST
HL
E
G
F
SP
NA
----
TVI
VL
V
L
VFY
FA
H
Y
L
FAS
L
SA
H
T
A
T
MLPV
IL
A
V
G
KGI
P
---
G
V
P
M
EQL
C
I
L
L
VL
SIG
I
M
G
C
LTPYATGPG
V
IIYG
C
GY
VKSK
DYWRLGAIFGVI
Y
ISM
LL
L
VG
WP
IL
A
M
W
N
fig|444449.5.peg.5475
Escherichia coli O157:H7 str. EC4042
M
APL
V
V
MG
VM
F
LIP
V
P
D
G
M
PPQ
AW
H
YFAVF
V
A
M
IVG
M
ILEP
I
P
AT
AI
SF
IAVTI
CV
I
G
S
NY
LLF
DAKE
LA
D
P
A
F
NAQ
K
QA
L
K
W
G
L
A
GFSS
T
T
V
WLVF
G
AF
I
F
AL
GYE
V
S
GLGRRIAL
F
LVK
F
MG
K
RTL
T
LGYA
I
V
I
I
D
I
L
LAP
F
TPSNTAR
T
GG
T
V
F
P
V
I
K
NLPPL
FK
S
F
PND
P
S
A
RRIG
G
YLMWM
MV
I
S
T
SL
S
S
S
MF
V
T
GA
APN
V
L
G
L
EF
V
SK
I
A
G
I
--
QISW
L
Q
WFL
CF
LP
V
G
V
ILL
I
I
A
PWL
S
YVLY
K
PEI
T
HS
E
E
V
A
TWA
GD
EL
KT
MG
A
L
TR
RE
W
T
L
I
GL
V
L
L
S
L
G
LW
V
FG
SEV
--
I
N
AT
A
VG
LL
A
V
S
LML
A
--
L
H
V
V
P
WKDI
T
R
YN
S
AWNTL
V
N
LA
T
L
V
V
M
A
N
GLT
RS
GFI
D
WFA
GTMST
HL
E
G
F
SP
NA
----
TVI
VL
V
L
VFY
FA
H
Y
L
FAS
L
SA
H
T
A
T
MLPV
IL
A
V
G
KGI
P
---
G
V
P
M
EQL
C
I
L
L
VL
SIG
I
M
G
C
LTPYATGPG
V
IIYG
C
GY
VKSK
DYWRLGAIFGVI
Y
ISM
LL
L
VG
WP
IL
A
M
W
N
fig|444453.5.peg.691
Escherichia coli O157:H7 str. EC4076
M
APL
V
V
MG
VM
F
LIP
V
P
D
G
M
PPQ
AW
H
YFAVF
V
A
M
IVG
M
ILEP
I
P
AT
AI
SF
IAVTI
CV
I
G
S
NY
LLF
DAKE
LA
D
P
A
F
NAQ
K
QA
L
K
W
G
L
A
GFSS
T
T
V
WLVF
G
AF
I
F
AL
GYE
V
S
GLGRRIAL
F
LVK
F
MG
K
RTL
T
LGYA
I
V
I
I
D
I
L
LAP
F
TPSNTAR
T
GG
T
V
F
P
V
I
K
NLPPL
FK
S
F
PND
P
S
A
RRIG
G
YLMWM
MV
I
S
T
SL
S
S
S
MF
V
T
GA
APN
V
L
G
L
EF
V
SK
I
A
G
I
--
QISW
L
Q
WFL
CF
LP
V
G
V
ILL
I
I
A
PWL
S
YVLY
K
PEI
T
HS
E
E
V
A
TWA
GD
EL
KT
MG
A
L
TR
RE
W
T
L
I
GL
V
L
L
S
L
G
LW
V
FG
SEV
--
I
N
AT
A
VG
LL
A
V
S
LML
A
--
L
H
V
V
P
WKDI
T
R
YN
S
AWNTL
V
N
LA
T
L
V
V
M
A
N
GLT
RS
GFI
D
WFA
GTMST
HL
E
G
F
SP
NA
----
TVI
VL
V
L
VFY
FA
H
Y
L
FAS
L
SA
H
T
A
T
MLPV
IL
A
V
G
KGI
P
---
G
V
P
M
EQL
C
I
L
L
VL
SIG
I
M
G
C
LTPYATGPG
V
IIYG
C
GY
VKSK
DYWRLGAIFGVI
Y
ISM
LL
L
VG
WP
IL
A
M
W
N
fig|444452.5.peg.836
Escherichia coli O157:H7 str. EC4113
M
APL
V
V
MG
VM
F
LIP
V
P
D
G
M
PPQ
AW
H
YFAVF
V
A
M
IVG
M
ILEP
I
P
AT
AI
SF
IAVTI
CV
I
G
S
NY
LLF
DAKE
LA
D
P
A
F
NAQ
K
QA
L
K
W
G
L
A
GFSS
T
T
V
WLVF
G
AF
I
F
AL
GYE
V
S
GLGRRIAL
F
LVK
F
MG
K
RTL
T
LGYA
I
V
I
I
D
I
L
LAP
F
TPSNTAR
T
GG
T
V
F
P
V
I
K
NLPPL
FK
S
F
PND
P
S
A
RRIG
G
YLMWM
MV
I
S
T
SL
S
S
S
MF
V
T
GA
APN
V
L
G
L
EF
V
SK
I
A
G
I
--
QISW
L
Q
WFL
CF
LP
V
G
V
ILL
I
I
A
PWL
S
YVLY
K
PEI
T
HS
E
E
V
A
TWA
GD
EL
KT
MG
A
L
TR
RE
W
T
L
I
GL
V
L
L
S
L
G
LW
V
FG
SEV
--
I
N
AT
A
VG
LL
A
V
S
LML
A
--
L
H
V
V
P
WKDI
T
R
YN
S
AWNTL
V
N
LA
T
L
V
V
M
A
N
GLT
RS
GFI
D
WFA
GTMST
HL
E
G
F
SP
NA
----
TVI
VL
V
L
VFY
FA
H
Y
L
FAS
L
SA
H
T
A
T
MLPV
IL
A
V
G
KGI
P
---
G
V
P
M
EQL
C
I
L
L
VL
SIG
I
M
G
C
LTPYATGPG
V
IIYG
C
GY
VKSK
DYWRLGAIFGVI
Y
ISM
LL
L
VG
WP
IL
A
M
W
N
fig|444450.8.peg.809
Escherichia coli O157:H7 str. EC4115
M
APL
V
V
MG
VM
F
LIP
V
P
D
G
M
PPQ
AW
H
YFAVF
V
A
M
IVG
M
ILEP
I
P
AT
AI
SF
IAVTI
CV
I
G
S
NY
LLF
DAKE
LA
D
P
A
F
NAQ
K
QA
L
K
W
G
L
A
GFSS
T
T
V
WLVF
G
AF
I
F
AL
GYE
V
S
GLGRRIAL
F
LVK
F
MG
K
RTL
T
LGYA
I
V
I
I
D
I
L
LAP
F
TPSNTAR
T
GG
T
V
F
P
V
I
K
NLPPL
FK
S
F
PND
P
S
A
RRIG
G
YLMWM
MV
I
S
T
SL
S
S
S
MF
V
T
GA
APN
V
L
G
L
EF
V
SK
I
A
G
I
--
QISW
L
Q
WFL
CF
LP
V
G
V
ILL
I
I
A
PWL
S
YVLY
K
PEI
T
HS
E
E
V
A
TWA
GD
EL
KT
MG
A
L
TR
RE
W
T
L
I
GL
V
L
L
S
L
G
LW
V
FG
SEV
--
I
N
AT
A
VG
LL
A
V
S
LML
A
--
L
H
V
V
P
WKDI
T
R
YN
S
AWNTL
V
N
LA
T
L
V
V
M
A
N
GLT
RS
GFI
D
WFA
GTMST
HL
E
G
F
SP
NA
----
TVI
VL
V
L
VFY
FA
H
Y
L
FAS
L
SA
H
T
A
T
MLPV
IL
A
V
G
KGI
P
---
G
V
P
M
EQL
C
I
L
L
VL
SIG
I
M
G
C
LTPYATGPG
V
IIYG
C
GY
VKSK
DYWRLGAIFGVI
Y
ISM
LL
L
VG
WP
IL
A
M
W
N
fig|444447.5.peg.3524
Escherichia coli O157:H7 str. EC4206
M
APL
V
V
MG
VM
F
LIP
V
P
D
G
M
PPQ
AW
H
YFAVF
V
A
M
IVG
M
ILEP
I
P
AT
AI
SF
IAVTI
CV
I
G
S
NY
LLF
DAKE
LA
D
P
A
F
NAQ
K
QA
L
K
W
G
L
A
GFSS
T
T
V
WLVF
G
AF
I
F
AL
GYE
V
S
GLGRRIAL
F
LVK
F
MG
K
RTL
T
LGYA
I
V
I
I
D
I
L
LAP
F
TPSNTAR
T
GG
T
V
F
P
V
I
K
NLPPL
FK
S
F
PND
P
S
A
RRIG
G
YLMWM
MV
I
S
T
SL
S
S
S
MF
V
T
GA
APN
V
L
G
L
EF
V
SK
I
A
G
I
--
QISW
L
Q
WFL
CF
LP
V
G
V
ILL
I
I
A
PWL
S
YVLY
K
PEI
T
HS
E
E
V
A
TWA
GD
EL
KT
MG
A
L
TR
RE
W
T
L
I
GL
V
L
L
S
L
G
LW
V
FG
SEV
--
I
N
AT
A
VG
LL
A
V
S
LML
A
--
L
H
V
V
P
WKDI
T
R
YN
S
AWNTL
V
N
LA
T
L
V
V
M
A
N
GLT
RS
GFI
D
WFA
GTMST
HL
E
G
F
SP
NA
----
TVI
VL
V
L
VFY
FA
H
Y
L
FAS
L
SA
H
T
A
T
MLPV
IL
A
V
G
KGI
P
---
G
V
P
M
EQL
C
I
L
L
VL
SIG
I
M
G
C
LTPYATGPG
V
IIYG
C
GY
VKSK
DYWRLGAIFGVI
Y
ISM
LL
L
VG
WP
IL
A
M
W
N
fig|478004.5.peg.1517
Escherichia coli O157:H7 str. EC4401
M
APL
V
V
MG
VM
F
LIP
V
P
D
G
M
PPQ
AW
H
YFAVF
V
A
M
IVG
M
ILEP
I
P
AT
AI
SF
IAVTI
CV
I
G
S
NY
LLF
DAKE
LA
D
P
A
F
NAQ
K
QA
L
K
W
G
L
A
GFSS
T
T
V
WLVF
G
AF
I
F
AL
GYE
V
S
GLGRRIAL
F
LVK
F
MG
K
RTL
T
LGYA
I
V
I
I
D
I
L
LAP
F
TPSNTAR
T
GG
T
V
F
P
V
I
K
NLPPL
FK
S
F
PND
P
S
A
RRIG
G
YLMWM
MV
I
S
T
SL
S
S
S
MF
V
T
GA
APN
V
L
G
L
EF
V
SK
I
A
G
I
--
QISW
L
Q
WFL
CF
LP
V
G
V
ILL
I
I
A
PWL
S
YVLY
K
PEI
T
HS
E
E
V
A
TWA
GD
EL
KT
MG
A
L
TR
RE
W
T
L
I
GL
V
L
L
S
L
G
LW
V
FG
SEV
--
I
N
AT
A
VG
LL
A
V
S
LML
A
--
L
H
V
V
P
WKDI
T
R
YN
S
AWNTL
V
N
LA
T
L
V
V
M
A
N
GLT
RS
GFI
D
WFA
GTMST
HL
E
G
F
SP
NA
----
TVI
VL
V
L
VFY
FA
H
Y
L
FAS
L
SA
H
T
A
T
MLPV
IL
A
V
G
KGI
P
---
G
V
P
M
EQL
C
I
L
L
VL
SIG
I
M
G
C
LTPYATGPG
V
IIYG
C
GY
VKSK
DYWRLGAIFGVI
Y
ISM
LL
L
VG
WP
IL
A
M
W
N
fig|478005.5.peg.4029
Escherichia coli O157:H7 str. EC4486
M
APL
V
V
MG
VM
F
LIP
V
P
D
G
M
PPQ
AW
H
YFAVF
V
A
M
IVG
M
ILEP
I
P
AT
AI
SF
IAVTI
CV
I
G
S
NY
LLF
DAKE
LA
D
P
A
F
NAQ
K
QA
L
K
W
G
L
A
GFSS
T
T
V
WLVF
G
AF
I
F
AL
GYE
V
S
GLGRRIAL
F
LVK
F
MG
K
RTL
T
LGYA
I
V
I
I
D
I
L
LAP
F
TPSNTAR
T
GG
T
V
F
P
V
I
K
NLPPL
FK
S
F
PND
P
S
A
RRIG
G
YLMWM
MV
I
S
T
SL
S
S
S
MF
V
T
GA
APN
V
L
G
L
EF
V
SK
I
A
G
I
--
QISW
L
Q
WFL
CF
LP
V
G
V
ILL
I
I
A
PWL
S
YVLY
K
PEI
T
HS
E
E
V
A
TWA
GD
EL
KT
MG
A
L
TR
RE
W
T
L
I
GL
V
L
L
S
L
G
LW
V
FG
SEV
--
I
N
AT
A
VG
LL
A
V
S
LML
A
--
L
H
V
V
P
WKDI
T
R
YN
S
AWNTL
V
N
LA
T
L
V
V
M
A
N
GLT
RS
GFI
D
WFA
GTMST
HL
E
G
F
SP
NA
----
TVI
VL
V
L
VFY
FA
H
Y
L
FAS
L
SA
H
T
A
T
MLPV
IL
A
V
G
KGI
P
---
G
V
P
M
EQL
C
I
L
L
VL
SIG
I
M
G
C
LTPYATGPG
V
IIYG
C
GY
VKSK
DYWRLGAIFGVI
Y
ISM
LL
L
VG
WP
IL
A
M
W
N
fig|478006.5.peg.793
Escherichia coli O157:H7 str. EC4501
M
APL
V
V
MG
VM
F
LIP
V
P
D
G
M
PPQ
AW
H
YFAVF
V
A
M
IVG
M
ILEP
I
P
AT
AI
SF
IAVTI
CV
I
G
S
NY
LLF
DAKE
LA
D
P
A
F
NAQ
K
QA
L
K
W
G
L
A
GFSS
T
T
V
WLVF
G
AF
I
F
AL
GYE
V
S
GLGRRIAL
F
LVK
F
MG
K
RTL
T
LGYA
I
V
I
I
D
I
L
LAP
F
TPSNTAR
T
GG
T
V
F
P
V
I
K
NLPPL
FK
S
F
PND
P
S
A
RRIG
G
YLMWM
MV
I
S
T
SL
S
S
S
MF
V
T
GA
APN
V
L
G
L
EF
V
SK
I
A
G
I
--
QISW
L
Q
WFL
CF
LP
V
G
V
ILL
I
I
A
PWL
S
YVLY
K
PEI
T
HS
E
E
V
A
TWA
GD
EL
KT
MG
A
L
TR
RE
W
T
L
I
GL
V
L
L
S
L
G
LW
V
FG
SEV
--
I
N
AT
A
VG
LL
A
V
S
LML
A
--
L
H
V
V
P
WKDI
T
R
YN
S
AWNTL
V
N
LA
T
L
V
V
M
A
N
GLT
RS
GFI
D
WFA
GTMST
HL
E
G
F
SP
NA
----
TVI
VL
V
L
VFY
FA
H
Y
L
FAS
L
SA
H
T
A
T
MLPV
IL
A
V
G
KGI
P
---
G
V
P
M
EQL
C
I
L
L
VL
SIG
I
M
G
C
LTPYATGPG
V
IIYG
C
GY
VKSK
DYWRLGAIFGVI
Y
ISM
LL
L
VG
WP
IL
A
M
W
N
fig|478008.5.peg.1751
Escherichia coli O157:H7 str. EC869
M
APL
V
V
MG
VM
F
LIP
V
P
D
G
M
PPQ
AW
H
YFAVF
V
A
M
IVG
M
ILEP
I
P
AT
AI
SF
IAVTI
CV
I
G
S
NY
LLF
DAKE
LA
D
P
A
F
NAQ
K
QA
L
K
W
G
L
A
GFSS
T
T
V
WLVF
G
AF
I
F
AL
GYE
V
S
GLGRRIAL
F
LVK
F
MG
K
RTL
T
LGYA
I
V
I
I
D
I
L
LAP
F
TPSNTAR
T
GG
T
V
F
P
V
I
K
NLPPL
FK
S
F
PND
P
S
A
RRIG
G
YLMWM
MV
I
S
T
SL
S
S
S
MF
V
T
GA
APN
V
L
G
L
EF
V
SK
I
A
G
I
--
QISW
L
Q
WFL
CF
LP
V
G
V
ILL
I
I
A
PWL
S
YVLY
K
PEI
T
HS
E
E
V
A
TWA
GD
EL
KT
MG
A
L
TR
RE
W
T
L
I
GL
V
L
L
S
L
G
LW
V
FG
SEV
--
I
N
AT
A
VG
LL
A
V
S
LML
A
--
L
H
V
V
P
WKDI
T
R
YN
S
AWNTL
V
N
LA
T
L
V
V
M
A
N
GLT
RS
GFI
D
WFA
GTMST
HL
E
G
F
SP
NA
----
TVI
VL
V
L
VFY
FA
H
Y
L
FAS
L
SA
H
T
A
T
MLPV
IL
A
V
G
KGI
P
---
G
V
P
M
EQL
C
I
L
L
VL
SIG
I
M
G
C
LTPYATGPG
V
IIYG
C
GY
VKSK
DYWRLGAIFGVI
Y
ISM
LL
L
VG
WP
IL
A
M
W
N
fig|386585.9.peg.762
Escherichia coli O157:H7 str. Sakai
M
APL
V
V
MG
VM
F
LIP
V
P
D
G
M
PPQ
AW
H
YFAVF
V
A
M
IVG
M
ILEP
I
P
AT
AI
SF
IAVTI
CV
I
G
S
NY
LLF
DAKE
LA
D
P
A
F
NAQ
K
QA
L
K
W
G
L
A
GFSS
T
T
V
WLVF
G
AF
I
F
AL
GYE
V
S
GLGRRIAL
F
LVK
F
MG
K
RTL
T
LGYA
I
V
I
I
D
I
L
LAP
F
TPSNTAR
T
GG
T
V
F
P
V
I
K
NLPPL
FK
S
F
PND
P
S
A
RRIG
G
YLMWM
MV
I
S
T
SL
S
S
S
MF
V
T
GA
APN
V
L
G
L
EF
V
SK
I
A
G
I
--
QISW
L
Q
WFL
CF
LP
V
G
V
ILL
I
I
A
PWL
S
YVLY
K
PEI
T
HS
E
E
V
A
TWA
GD
EL
KT
MG
A
L
TR
RE
W
T
L
I
GL
V
L
L
S
L
G
LW
V
FG
SEV
--
I
N
AT
A
VG
LL
A
V
S
LML
A
--
L
H
V
V
P
WKDI
T
R
YN
S
AWNTL
V
N
LA
T
L
V
V
M
A
N
GLT
RS
GFI
D
WFA
GTMST
HL
E
G
F
SP
NA
----
TVI
VL
V
L
VFY
FA
H
Y
L
FAS
L
SA
H
T
A
T
MLPV
IL
A
V
G
KGI
P
---
G
V
P
M
EQL
C
I
L
L
VL
SIG
I
M
G
C
LTPYATGPG
V
IIYG
C
GY
VKSK
DYWRLGAIFGVI
Y
ISM
LL
L
VG
WP
IL
A
M
W
N
fig|544404.4.peg.674
Escherichia coli O157:H7 str. TW14359
M
APL
V
V
MG
VM
F
LIP
V
P
D
G
M
PPQ
AW
H
YFAVF
V
A
M
IVG
M
ILEP
I
P
AT
AI
SF
IAVTI
CV
I
G
S
NY
LLF
DAKE
LA
D
P
A
F
NAQ
K
QA
L
K
W
G
L
A
GFSS
T
T
V
WLVF
G
AF
I
F
AL
GYE
V
S
GLGRRIAL
F
LVK
F
MG
K
RTL
T
LGYA
I
V
I
I
D
I
L
LAP
F
TPSNTAR
T
GG
T
V
F
P
V
I
K
NLPPL
FK
S
F
PND
P
S
A
RRIG
G
YLMWM
MV
I
S
T
SL
S
S
S
MF
V
T
GA
APN
V
L
G
L
EF
V
SK
I
A
G
I
--
QISW
L
Q
WFL
CF
LP
V
G
V
ILL
I
I
A
PWL
S
YVLY
K
PEI
T
HS
E
E
V
A
TWA
GD
EL
KT
MG
A
L
TR
RE
W
T
L
I
GL
V
L
L
S
L
G
LW
V
FG
SEV
--
I
N
AT
A
VG
LL
A
V
S
LML
A
--
L
H
V
V
P
WKDI
T
R
YN
S
AWNTL
V
N
LA
T
L
V
V
M
A
N
GLT
RS
GFI
D
WFA
GTMST
HL
E
G
F
SP
NA
----
TVI
VL
V
L
VFY
FA
H
Y
L
FAS
L
SA
H
T
A
T
MLPV
IL
A
V
G
KGI
P
---
G
V
P
M
EQL
C
I
L
L
VL
SIG
I
M
G
C
LTPYATGPG
V
IIYG
C
GY
VKSK
DYWRLGAIFGVI
Y
ISM
LL
L
VG
WP
IL
A
M
W
N
fig|502346.5.peg.546
Escherichia coli O157:H7 str. TW14588
M
APL
V
V
MG
VM
F
LIP
V
P
D
G
M
PPQ
AW
H
YFAVF
V
A
M
IVG
M
ILEP
I
P
AT
AI
SF
IAVTI
CV
I
G
S
NY
LLF
DAKE
LA
D
P
A
F
NAQ
K
QA
L
K
W
G
L
A
GFSS
T
T
V
WLVF
G
AF
I
F
AL
GYE
V
S
GLGRRIAL
F
LVK
F
MG
K
RTL
T
LGYA
I
V
I
I
D
I
L
LAP
F
TPSNTAR
T
GG
T
V
F
P
V
I
K
NLPPL
FK
S
F
PND
P
S
A
RRIG
G
YLMWM
MV
I
S
T
SL
S
S
S
MF
V
T
GA
APN
V
L
G
L
EF
V
SK
I
A
G
I
--
QISW
L
Q
WFL
CF
LP
V
G
V
ILL
I
I
A
PWL
S
YVLY
K
PEI
T
HS
E
E
V
A
TWA
GD
EL
KT
MG
A
L
TR
RE
W
T
L
I
GL
V
L
L
S
L
G
LW
V
FG
SEV
--
I
N
AT
A
VG
LL
A
V
S
LML
A
--
L
H
V
V
P
WKDI
T
R
YN
S
AWNTL
V
N
LA
T
L
V
V
M
A
N
GLT
RS
GFI
D
WFA
GTMST
HL
E
G
F
SP
NA
----
TVI
VL
V
L
VFY
FA
H
Y
L
FAS
L
SA
H
T
A
T
MLPV
IL
A
V
G
KGI
P
---
G
V
P
M
EQL
C
I
L
L
VL
SIG
I
M
G
C
LTPYATGPG
V
IIYG
C
GY
VKSK
DYWRLGAIFGVI
Y
ISM
LL
L
VG
WP
IL
A
M
W
N
fig|409438.11.peg.804
Escherichia coli SE11
M
APL
V
V
MG
VM
F
LIP
V
P
D
G
M
PPQ
AW
H
YFAVF
V
A
M
IVG
M
ILEP
I
P
AT
AI
SF
IAVTI
CV
I
G
S
NY
LLF
DAKE
LA
D
P
A
F
NAQ
K
QA
L
K
W
G
L
A
GFSS
T
T
V
WLVF
G
AF
I
F
AL
GYE
V
S
GLGRRIAL
F
LVK
F
MG
K
RTL
T
LGYA
I
V
I
I
D
I
L
LAP
F
TPSNTAR
T
GG
T
V
F
P
V
I
K
NLPPL
FK
S
F
PND
P
S
A
RRIG
G
YLMWM
MV
I
S
T
SL
S
S
S
MF
V
T
GA
APN
V
L
G
L
EF
V
SK
I
A
G
I
--
QISW
L
Q
WFL
CF
LP
V
G
V
ILL
I
I
A
PWL
S
YVLY
K
PEI
T
HS
E
E
V
A
TWA
GD
EL
KT
MG
A
L
TR
RE
W
T
L
I
GL
V
L
L
S
L
G
LW
V
FG
SEV
--
I
N
AT
A
VG
LL
A
V
S
LML
A
--
L
H
V
V
P
WKDI
T
R
YN
S
AWNTL
V
N
LA
T
L
V
V
M
A
N
GLT
RS
GFI
D
WFA
GTMST
HL
E
G
F
SP
NA
----
TVI
VL
V
L
VFY
FA
H
Y
L
FAS
L
SA
H
T
A
T
MLPV
IL
A
V
G
KGI
P
---
G
V
P
M
EQL
C
I
L
L
VL
SIG
I
M
G
C
LTPYATGPG
V
IIYG
C
GY
VKSK
DYWRLGAIFGVI
Y
ISM
LL
L
VG
WP
IL
A
M
W
N
fig|656443.3.peg.871
Escherichia coli TA271
M
APL
V
V
MG
VM
F
LIP
V
P
D
G
M
PPQ
AW
H
YFAVF
V
A
M
IVG
M
ILEP
I
P
AT
AI
SF
IAVTI
CV
I
G
S
NY
LLF
DAKE
LA
D
P
A
F
NAQ
K
QA
L
K
W
G
L
A
GFSS
T
T
V
WLVF
G
AF
I
F
AL
GYE
V
S
GLGRRIAL
F
LVK
F
MG
K
RTL
T
LGYA
I
V
I
I
D
I
L
LAP
F
TPSNTAR
T
GG
T
V
F
P
V
I
K
NLPPL
FK
S
F
PND
P
S
A
RRIG
G
YLMWM
MV
I
S
T
SL
S
S
S
MF
V
T
GA
APN
V
L
G
L
EF
V
SK
I
A
G
I
--
QISW
L
Q
WFL
CF
LP
V
G
V
ILL
I
I
A
PWL
S
YVLY
K
PEI
T
HS
E
E
V
A
TWA
GD
EL
KT
MG
A
L
TR
RE
W
T
L
I
GL
V
L
L
S
L
G
LW
V
FG
SEV
--
I
N
AT
A
VG
LL
A
V
S
LML
A
--
L
H
V
V
P
WKDI
T
R
YN
S
AWNTL
V
N
LA
T
L
V
V
M
A
N
GLT
RS
GFI
D
WFA
GTMST
HL
E
G
F
SP
NA
----
TVI
VL
V
L
VFY
FA
H
Y
L
FAS
L
SA
H
T
A
T
MLPV
IL
A
V
G
KGI
P
---
G
V
P
M
EQL
C
I
L
L
VL
SIG
I
M
G
C
LTPYATGPG
V
IIYG
C
GY
VKSK
DYWRLGAIFGVI
Y
ISM
LL
L
VG
WP
IL
A
M
W
N
fig|585056.7.peg.903
Escherichia coli UMN026
M
APL
V
V
MG
VM
F
LIP
V
P
D
G
M
PPQ
AW
H
YFAVF
V
A
M
IVG
M
ILEP
I
P
AT
AI
SF
IAVTI
CV
I
G
S
NY
LLF
DAKE
LA
D
P
A
F
NAQ
K
QA
L
K
W
G
L
A
GFSS
T
T
V
WLVF
G
AF
I
F
AL
GYE
V
S
GLGRRIAL
F
LVK
F
MG
K
RTL
T
LGYA
I
V
I
I
D
I
L
LAP
F
TPSNTAR
T
GG
T
V
F
P
V
I
K
NLPPL
FK
S
F
PND
P
S
A
RRIG
G
YLMWM
MV
I
S
T
SL
S
S
S
MF
V
T
GA
APN
V
L
G
L
EF
V
SK
I
A
G
I
--
QISW
L
Q
WFL
CF
LP
V
G
V
ILL
I
I
A
PWL
S
YVLY
K
PEI
T
HS
E
E
V
A
TWA
GD
EL
KT
MG
A
L
TR
RE
W
T
L
I
GL
V
L
L
S
L
G
LW
V
FG
SEV
--
I
N
AT
A
VG
LL
A
V
S
LML
A
--
L
H
V
V
P
WKDI
T
R
YN
S
AWNTL
V
N
LA
T
L
V
V
M
A
N
GLT
RS
GFI
D
WFA
GTMST
HL
E
G
F
SP
NA
----
TVI
VL
V
L
VFY
FA
H
Y
L
FAS
L
SA
H
T
A
T
MLPV
IL
A
V
G
KGI
P
---
G
V
P
M
EQL
C
I
L
L
VL
SIG
I
M
G
C
LTPYATGPG
V
IIYG
C
GY
VKSK
DYWRLGAIFGVI
Y
ISM
LL
L
VG
WP
IL
A
M
W
N
fig|566546.3.peg.2835
Escherichia coli W
M
APL
V
V
MG
VM
F
LIP
V
P
D
G
M
PPQ
AW
H
YFAVF
V
A
M
IVG
M
ILEP
I
P
AT
AI
SF
IAVTI
CV
I
G
S
NY
LLF
DAKE
LA
D
P
A
F
NAQ
K
QA
L
K
W
G
L
A
GFSS
T
T
V
WLVF
G
AF
I
F
AL
GYE
V
S
GLGRRIAL
F
LVK
F
MG
K
RTL
T
LGYA
I
V
I
I
D
I
L
LAP
F
TPSNTAR
T
GG
T
V
F
P
V
I
K
NLPPL
FK
S
F
PND
P
S
A
RRIG
G
YLMWM
MV
I
S
T
SL
S
S
S
MF
V
T
GA
APN
V
L
G
L
EF
V
SK
I
A
G
I
--
QISW
L
Q
WFL
CF
LP
V
G
V
ILL
I
I
A
PWL
S
YVLY
K
PEI
T
HS
E
E
V
A
TWA
GD
EL
KT
MG
A
L
TR
RE
W
T
L
I
GL
V
L
L
S
L
G
LW
V
FG
SEV
--
I
N
AT
A
VG
LL
A
V
S
LML
A
--
L
H
V
V
P
WKDI
T
R
YN
S
AWNTL
V
N
LA
T
L
V
V
M
A
N
GLT
RS
GFI
D
WFA
GTMST
HL
E
G
F
SP
NA
----
TVI
VL
V
L
VFY
FA
H
Y
L
FAS
L
SA
H
T
A
T
MLPV
IL
A
V
G
KGI
P
---
G
V
P
M
EQL
C
I
L
L
VL
SIG
I
M
G
C
LTPYATGPG
V
IIYG
C
GY
VKSK
DYWRLGAIFGVI
Y
ISM
LL
L
VG
WP
IL
A
M
W
N
fig|566546.4.peg.672
Escherichia coli W
M
APL
V
V
MG
VM
F
LIP
V
P
D
G
M
PPQ
AW
H
YFAVF
V
A
M
IVG
M
ILEP
I
P
AT
AI
SF
IAVTI
CV
I
G
S
NY
LLF
DAKE
LA
D
P
A
F
NAQ
K
QA
L
K
W
G
L
A
GFSS
T
T
V
WLVF
G
AF
I
F
AL
GYE
V
S
GLGRRIAL
F
LVK
F
MG
K
RTL
T
LGYA
I
V
I
I
D
I
L
LAP
F
TPSNTAR
T
GG
T
V
F
P
V
I
K
NLPPL
FK
S
F
PND
P
S
A
RRIG
G
YLMWM
MV
I
S
T
SL
S
S
S
MF
V
T
GA
APN
V
L
G
L
EF
V
SK
I
A
G
I
--
QISW
L
Q
WFL
CF
LP
V
G
V
ILL
I
I
A
PWL
S
YVLY
K
PEI
T
HS
E
E
V
A
TWA
GD
EL
KT
MG
A
L
TR
RE
W
T
L
I
GL
V
L
L
S
L
G
LW
V
FG
SEV
--
I
N
AT
A
VG
LL
A
V
S
LML
A
--
L
H
V
V
P
WKDI
T
R
YN
S
AWNTL
V
N
LA
T
L
V
V
M
A
N
GLT
RS
GFI
D
WFA
GTMST
HL
E
G
F
SP
NA
----
TVI
VL
V
L
VFY
FA
H
Y
L
FAS
L
SA
H
T
A
T
MLPV
IL
A
V
G
KGI
P
---
G
V
P
M
EQL
C
I
L
L
VL
SIG
I
M
G
C
LTPYATGPG
V
IIYG
C
GY
VKSK
DYWRLGAIFGVI
Y
ISM
LL
L
VG
WP
IL
A
M
W
N
fig|511145.12.peg.642
Escherichia coli str. K-12 substr. MG1655
M
APL
V
V
MG
VM
F
LIP
V
P
D
G
M
PPQ
AW
H
YFAVF
V
A
M
IVG
M
ILEP
I
P
AT
AI
SF
IAVTI
CV
I
G
S
NY
LLF
DAKE
LA
D
P
A
F
NAQ
K
QA
L
K
W
G
L
A
GFSS
T
T
V
WLVF
G
AF
I
F
AL
GYE
V
S
GLGRRIAL
F
LVK
F
MG
K
RTL
T
LGYA
I
V
I
I
D
I
L
LAP
F
TPSNTAR
T
GG
T
V
F
P
V
I
K
NLPPL
FK
S
F
PND
P
S
A
RRIG
G
YLMWM
MV
I
S
T
SL
S
S
S
MF
V
T
GA
APN
V
L
G
L
EF
V
SK
I
A
G
I
--
QISW
L
Q
WFL
CF
LP
V
G
V
ILL
I
I
A
PWL
S
YVLY
K
PEI
T
HS
E
E
V
A
TWA
GD
EL
KT
MG
A
L
TR
RE
W
T
L
I
GL
V
L
L
S
L
G
LW
V
FG
SEV
--
I
N
AT
A
VG
LL
A
V
S
LML
A
--
L
H
V
V
P
WKDI
T
R
YN
S
AWNTL
V
N
LA
T
L
V
V
M
A
N
GLT
RS
GFI
D
WFA
GTMST
HL
E
G
F
SP
NA
----
TVI
VL
V
L
VFY
FA
H
Y
L
FAS
L
SA
H
T
A
T
MLPV
IL
A
V
G
KGI
P
---
G
V
P
M
EQL
C
I
L
L
VL
SIG
I
M
G
C
LTPYATGPG
V
IIYG
C
GY
VKSK
DYWRLGAIFGVI
Y
ISM
LL
L
VG
WP
IL
A
M
W
N
fig|511145.6.peg.633
Escherichia coli str. K-12 substr. MG1655
M
APL
V
V
MG
VM
F
LIP
V
P
D
G
M
PPQ
AW
H
YFAVF
V
A
M
IVG
M
ILEP
I
P
AT
AI
SF
IAVTI
CV
I
G
S
NY
LLF
DAKE
LA
D
P
A
F
NAQ
K
QA
L
K
W
G
L
A
GFSS
T
T
V
WLVF
G
AF
I
F
AL
GYE
V
S
GLGRRIAL
F
LVK
F
MG
K
RTL
T
LGYA
I
V
I
I
D
I
L
LAP
F
TPSNTAR
T
GG
T
V
F
P
V
I
K
NLPPL
FK
S
F
PND
P
S
A
RRIG
G
YLMWM
MV
I
S
T
SL
S
S
S
MF
V
T
GA
APN
V
L
G
L
EF
V
SK
I
A
G
I
--
QISW
L
Q
WFL
CF
LP
V
G
V
ILL
I
I
A
PWL
S
YVLY
K
PEI
T
HS
E
E
V
A
TWA
GD
EL
KT
MG
A
L
TR
RE
W
T
L
I
GL
V
L
L
S
L
G
LW
V
FG
SEV
--
I
N
AT
A
VG
LL
A
V
S
LML
A
--
L
H
V
V
P
WKDI
T
R
YN
S
AWNTL
V
N
LA
T
L
V
V
M
A
N
GLT
RS
GFI
D
WFA
GTMST
HL
E
G
F
SP
NA
----
TVI
VL
V
L
VFY
FA
H
Y
L
FAS
L
SA
H
T
A
T
MLPV
IL
A
V
G
KGI
P
---
G
V
P
M
EQL
C
I
L
L
VL
SIG
I
M
G
C
LTPYATGPG
V
IIYG
C
GY
VKSK
DYWRLGAIFGVI
Y
ISM
LL
L
VG
WP
IL
A
M
W
N
fig|216592.1.peg.369
Escherichia coli 042 (12-487/487)
LAPL
V
V
MG
VM
F
LIP
V
P
D
G
M
PPQ
AW
H
YFAVF
V
A
M
IVG
M
ILEP
I
P
AT
AI
SF
IAVTI
CV
I
G
S
NY
LLF
DAKE
LA
D
P
A
F
NAQ
K
QA
L
K
W
G
L
A
GFSS
T
T
V
WLVF
G
AF
I
F
AL
GYE
V
S
GLGRRIAL
F
LVK
F
MG
K
RTL
T
LGYA
I
V
I
I
D
I
L
LAP
F
TPSNTAR
T
GG
T
V
F
P
V
I
K
NLPPL
FK
S
F
PND
P
S
S
RRIG
G
YLMWM
MV
I
S
T
SL
S
S
S
MF
V
T
GA
APN
V
L
G
L
EF
V
NK
I
A
G
I
--
QISW
L
Q
WFL
CF
LP
V
G
V
ILL
I
I
A
PWL
S
YVLY
K
PEI
T
HS
E
E
V
A
TWA
GD
EL
KT
MG
A
L
TR
RE
W
T
L
I
GL
V
L
L
S
L
G
LW
V
FG
SEV
--
I
N
AT
A
VG
LL
A
V
S
LML
A
--
L
H
V
V
P
WKDI
T
R
YN
S
AWNTL
V
N
LA
T
L
V
V
M
A
N
GLT
RS
GFI
D
WFA
GTMST
HL
E
G
F
SP
NA
----
TVI
VL
V
L
VFY
FA
H
Y
L
FAS
L
SA
H
T
A
T
MLPV
IL
A
V
G
KGI
P
---
G
V
P
M
EQL
C
I
L
L
VL
SIG
I
M
G
C
LTPYATGPG
V
IIYG
C
GY
VKSK
DYWRLGAIFGVI
Y
ISM
LL
L
VG
WP
IL
A
M
W
N
fig|216592.3.peg.676
Escherichia coli 042 (12-487/487)
LAPL
V
V
MG
VM
F
LIP
V
P
D
G
M
PPQ
AW
H
YFAVF
V
A
M
IVG
M
ILEP
I
P
AT
AI
SF
IAVTI
CV
I
G
S
NY
LLF
DAKE
LA
D
P
A
F
NAQ
K
QA
L
K
W
G
L
A
GFSS
T
T
V
WLVF
G
AF
I
F
AL
GYE
V
S
GLGRRIAL
F
LVK
F
MG
K
RTL
T
LGYA
I
V
I
I
D
I
L
LAP
F
TPSNTAR
T
GG
T
V
F
P
V
I
K
NLPPL
FK
S
F
PND
P
S
S
RRIG
G
YLMWM
MV
I
S
T
SL
S
S
S
MF
V
T
GA
APN
V
L
G
L
EF
V
NK
I
A
G
I
--
QISW
L
Q
WFL
CF
LP
V
G
V
ILL
I
I
A
PWL
S
YVLY
K
PEI
T
HS
E
E
V
A
TWA
GD
EL
KT
MG
A
L
TR
RE
W
T
L
I
GL
V
L
L
S
L
G
LW
V
FG
SEV
--
I
N
AT
A
VG
LL
A
V
S
LML
A
--
L
H
V
V
P
WKDI
T
R
YN
S
AWNTL
V
N
LA
T
L
V
V
M
A
N
GLT
RS
GFI
D
WFA
GTMST
HL
E
G
F
SP
NA
----
TVI
VL
V
L
VFY
FA
H
Y
L
FAS
L
SA
H
T
A
T
MLPV
IL
A
V
G
KGI
P
---
G
V
P
M
EQL
C
I
L
L
VL
SIG
I
M
G
C
LTPYATGPG
V
IIYG
C
GY
VKSK
DYWRLGAIFGVI
Y
ISM
LL
L
VG
WP
IL
A
M
W
N
fig|701177.3.peg.774
Escherichia coli O55:H7 str. CB9615
M
APL
V
V
MG
VM
F
LIP
V
P
D
G
M
PPQ
AW
H
YFAVF
V
A
M
IVG
M
ILEP
I
P
AT
AI
SF
IAVTI
CV
I
G
S
NY
LLF
DAKE
LA
D
P
A
F
NAQ
K
QA
L
K
W
G
L
A
GFSS
T
T
V
WLVF
G
AF
I
F
AL
GYE
V
S
GLGRRIAL
F
Q
VK
F
MG
K
RTL
T
LGYA
I
V
I
I
D
I
L
LAP
F
TPSNTAR
T
GG
T
V
F
P
V
I
K
NLPPL
FK
S
F
PND
P
S
A
RRIG
G
YLMWM
MV
I
S
T
SL
S
S
S
MF
V
T
GA
APN
V
L
G
L
EF
V
SK
I
A
G
I
--
QISW
L
Q
WFL
CF
LP
V
G
V
ILL
I
I
A
PWL
S
YVLY
K
PEI
T
HS
E
E
V
A
TWA
GD
EL
KT
MG
A
L
TR
RE
W
T
L
I
GL
V
L
L
S
L
G
LW
V
FG
SEV
--
I
N
AT
A
VG
LL
A
V
S
LML
A
--
L
H
V
V
P
WKDI
T
R
YN
S
AWNTL
V
N
LA
T
L
V
V
M
A
N
GLT
RS
GFI
D
WFA
GTMST
HL
E
G
F
SP
NA
----
TVI
VL
V
L
VFY
FA
H
Y
L
FAS
L
SA
H
T
A
T
MLPV
IL
A
V
G
KGI
P
---
G
V
P
M
EQL
C
I
L
L
VL
SIG
I
M
G
C
LTPYATGPG
V
IIYG
C
GY
VKSK
DYWRLGAIFGVI
Y
ISM
LL
L
VG
WP
IL
A
M
W
N
fig|585396.4.peg.668
Escherichia coli O111:H- str. 11128 (12-487/487)
LAPL
V
V
MG
VM
F
LIP
V
P
D
G
M
PPR
AW
H
YFAVF
V
A
M
IVG
M
ILEP
I
P
AT
AI
SF
IAVTI
CV
I
G
S
NY
LLF
DAKE
LA
D
P
A
F
NAQ
K
QA
L
K
W
G
L
A
GFSS
T
T
V
WLVF
G
AF
I
F
AL
GYE
V
S
GLGRRIAL
F
LVK
F
MG
K
RTL
T
LGYA
I
V
I
I
D
I
L
LAP
F
TPSNTAR
T
GG
T
V
F
P
V
I
K
NLPPL
FK
S
F
PND
P
S
A
RRIG
G
YLMWM
MV
I
S
T
SL
S
S
S
MF
V
T
GA
APN
V
L
G
L
EF
V
SK
I
A
G
I
--
QISW
L
Q
WFL
CF
LP
V
G
V
ILL
I
I
A
PWL
S
YVLY
K
PEI
T
HS
E
E
V
A
TWA
GD
EL
KT
MG
A
L
TR
RE
W
T
L
I
GL
V
L
L
S
L
G
LW
V
FG
SEV
--
I
N
AT
A
VG
LL
A
V
S
LML
A
--
L
H
V
V
P
WKDI
T
R
YN
S
AWNTL
V
N
LA
T
L
V
V
M
A
N
GLT
RS
GFI
D
WFA
GTMST
HL
E
G
F
SP
NA
----
TVI
VL
V
L
VFY
FA
H
Y
L
FAS
L
SA
H
T
A
T
MLPV
IL
A
V
G
KGI
P
---
G
V
P
M
EQL
C
I
L
L
VL
SIG
I
M
G
C
LTPYATGPG
V
IIYG
C
GY
VKSK
DYWRLGAIFGVI
Y
ISM
LL
L
VG
WP
IL
A
M
W
N
fig|405955.9.peg.487
Escherichia coli APEC O1 (12-487/487)
LAPL
V
V
MG
VM
F
LIP
V
P
D
G
M
PPQ
AW
H
YFAVF
V
A
M
IVG
M
ILEP
I
P
AT
AI
SF
IAVTI
CV
I
G
S
NY
LLF
DAKE
LA
D
P
A
F
NAQ
K
QA
L
K
W
G
L
A
GFSS
T
T
V
WLVF
G
AF
I
F
AL
GYE
V
S
GLGRRIAL
F
LVK
F
MG
K
RTL
T
LGYA
I
V
I
I
D
I
L
LAP
F
TPSNTAR
T
GG
T
V
F
P
V
I
K
NLPPL
FK
S
F
PND
P
S
A
RRIG
G
YLMWM
MV
I
S
T
SL
S
S
S
MF
V
T
GA
APN
V
L
G
L
EF
V
SK
I
A
G
I
--
QISW
L
Q
WFL
CF
LP
V
G
V
ILL
I
I
A
PWL
S
YVLY
K
PEI
T
HS
E
E
V
A
TWA
GD
EL
KT
MG
A
L
TR
RE
W
T
L
I
GL
V
L
L
S
L
G
LW
V
FG
SEV
--
I
N
AT
A
VG
LL
A
V
S
LML
A
--
L
H
V
V
P
WKDI
T
R
YN
S
AWNTL
V
N
LA
T
L
V
V
M
A
N
GLT
RS
GFI
D
WFA
NTMST
HL
E
G
F
SP
NA
----
TVI
VL
V
L
VFY
FA
H
Y
L
FAS
L
SA
H
T
A
T
MLPV
IL
A
V
G
KGI
P
---
G
V
P
M
EQL
C
I
L
L
VL
SIG
I
M
G
C
LTPYATGPG
V
IIYG
C
GY
VKSK
DYWRLGAIFGVI
Y
ISM
LL
L
VG
WP
IL
A
M
W
N
fig|199310.1.peg.675
Escherichia coli CFT073 (12-487/487)
LAPL
V
V
MG
VM
F
LIP
V
P
D
G
M
PPQ
AW
H
YFAVF
V
A
M
IVG
M
ILEP
I
P
AT
AI
SF
IAVTI
CV
I
G
S
NY
LLF
DAKE
LA
D
P
A
F
NAQ
K
QA
L
K
W
G
L
A
GFSS
T
T
V
WLVF
G
AF
I
F
AL
GYE
V
S
GLGRRIAL
F
LVK
F
MG
K
RTL
T
LGYA
I
V
I
I
D
I
L
LAP
F
TPSNTAR
T
GG
T
V
F
P
V
I
K
NLPPL
FK
S
F
PND
P
S
A
RRIG
G
YLMWM
MV
I
S
T
SL
S
S
S
MF
V
T
GA
APN
V
L
G
L
EF
V
SK
I
A
G
I
--
QISW
L
Q
WFL
CF
LP
V
G
V
ILL
I
I
A
PWL
S
YVLY
K
PEI
T
HS
E
E
V
A
TWA
GD
EL
KT
MG
A
L
TR
RE
W
T
L
I
GL
V
L
L
S
L
G
LW
V
FG
SEV
--
I
N
AT
A
VG
LL
A
V
S
LML
A
--
L
H
V
V
P
WKDI
T
R
YN
S
AWNTL
V
N
LA
T
L
V
V
M
A
N
GLT
RS
GFI
D
WFA
NTMST
HL
E
G
F
SP
NA
----
TVI
VL
V
L
VFY
FA
H
Y
L
FAS
L
SA
H
T
A
T
MLPV
IL
A
V
G
KGI
P
---
G
V
P
M
EQL
C
I
L
L
VL
SIG
I
M
G
C
LTPYATGPG
V
IIYG
C
GY
VKSK
DYWRLGAIFGVI
Y
ISM
LL
L
VG
WP
IL
A
M
W
N
fig|216593.1.peg.3006
Escherichia coli E2348/69 (12-487/487)
LAPL
V
V
MG
VM
F
LIP
V
P
D
G
M
PPQ
AW
H
YFAVF
V
A
M
IVG
M
ILEP
I
P
AT
AI
SF
IAVTI
CV
I
G
S
NY
LLF
DAKE
LA
D
P
A
F
NAQ
K
QA
L
K
W
G
L
A
GFSS
T
T
V
WLVF
G
AF
I
F
AL
GYE
V
S
GLGRRIAL
F
LVK
F
MG
K
RTL
T
LGYA
I
V
I
I
D
I
L
LAP
F
TPSNTAR
T
GG
T
V
F
P
V
I
K
NLPPL
FK
S
F
PND
P
S
A
RRIG
G
YLMWM
MV
I
S
T
SL
S
S
S
MF
V
T
GA
APN
V
L
G
L
EF
V
SK
I
A
G
I
--
QISW
L
Q
WFL
CF
LP
V
G
V
ILL
I
I
A
PWL
S
YVLY
K
PEI
T
HS
E
E
V
A
TWA
GD
EL
KT
MG
A
L
TR
RE
W
T
L
I
GL
V
L
L
S
L
G
LW
V
FG
SEV
--
I
N
AT
A
VG
LL
A
V
S
LML
A
--
L
H
V
V
P
WKDI
T
R
YN
S
AWNTL
V
N
LA
T
L
V
V
M
A
N
GLT
RS
GFI
D
WFA
NTMST
HL
E
G
F
SP
NA
----
TVI
VL
V
L
VFY
FA
H
Y
L
FAS
L
SA
H
T
A
T
MLPV
IL
A
V
G
KGI
P
---
G
V
P
M
EQL
C
I
L
L
VL
SIG
I
M
G
C
LTPYATGPG
V
IIYG
C
GY
VKSK
DYWRLGAIFGVI
Y
ISM
LL
L
VG
WP
IL
A
M
W
N
fig|340197.3.peg.2450
Escherichia coli F11 (12-487/487)
LAPL
V
V
MG
VM
F
LIP
V
P
D
G
M
PPQ
AW
H
YFAVF
V
A
M
IVG
M
ILEP
I
P
AT
AI
SF
IAVTI
CV
I
G
S
NY
LLF
DAKE
LA
D
P
A
F
NAQ
K
QA
L
K
W
G
L
A
GFSS
T
T
V
WLVF
G
AF
I
F
AL
GYE
V
S
GLGRRIAL
F
LVK
F
MG
K
RTL
T
LGYA
I
V
I
I
D
I
L
LAP
F
TPSNTAR
T
GG
T
V
F
P
V
I
K
NLPPL
FK
S
F
PND
P
S
A
RRIG
G
YLMWM
MV
I
S
T
SL
S
S
S
MF
V
T
GA
APN
V
L
G
L
EF
V
SK
I
A
G
I
--
QISW
L
Q
WFL
CF
LP
V
G
V
ILL
I
I
A
PWL
S
YVLY
K
PEI
T
HS
E
E
V
A
TWA
GD
EL
KT
MG
A
L
TR
RE
W
T
L
I
GL
V
L
L
S
L
G
LW
V
FG
SEV
--
I
N
AT
A
VG
LL
A
V
S
LML
A
--
L
H
V
V
P
WKDI
T
R
YN
S
AWNTL
V
N
LA
T
L
V
V
M
A
N
GLT
RS
GFI
D
WFA
NTMST
HL
E
G
F
SP
NA
----
TVI
VL
V
L
VFY
FA
H
Y
L
FAS
L
SA
H
T
A
T
MLPV
IL
A
V
G
KGI
P
---
G
V
P
M
EQL
C
I
L
L
VL
SIG
I
M
G
C
LTPYATGPG
V
IIYG
C
GY
VKSK
DYWRLGAIFGVI
Y
ISM
LL
L
VG
WP
IL
A
M
W
N
fig|362663.8.peg.647
Escherichia coli 536
M
APL
V
V
MG
VM
F
LIP
V
P
D
G
M
PPQ
AW
H
YFAVF
V
A
M
IVG
M
ILEP
I
P
AT
AI
SF
IAVTI
CV
I
G
S
NY
LLF
DAKE
LA
D
P
A
F
NAQ
K
QA
L
K
W
G
L
A
GFSS
T
T
V
WLVF
G
AF
I
F
AL
GYE
V
S
GLGRRIAL
F
LVK
F
MG
K
RTL
T
LGYA
I
V
I
I
D
I
L
LAP
F
TPSNTAR
T
GG
T
V
F
P
V
I
K
NLPPL
FK
S
F
PND
P
S
A
RRIG
G
YLMWM
MV
I
S
T
SL
S
S
S
MF
V
T
GA
APN
V
L
G
L
EF
V
SK
I
A
G
I
--
QISW
L
Q
WFL
CF
LP
V
G
V
ILL
I
I
A
PWL
S
YVLY
K
PEI
T
HS
E
E
V
A
TWA
GD
EL
KT
MG
A
L
TR
RE
W
T
L
I
GL
V
L
L
S
L
G
LW
V
FG
SEV
--
I
N
AT
A
VG
LL
A
V
S
LML
A
--
L
H
V
V
P
WKDI
T
R
YN
S
AWNTL
V
N
LA
T
L
V
V
M
A
N
GLT
RS
GFI
D
WFA
NTMST
HL
E
G
F
SP
NA
----
TVI
VL
V
L
VFY
FA
H
Y
L
FAS
L
SA
H
T
A
T
MLPV
IL
A
V
G
KGI
P
---
G
V
P
M
EQL
C
I
L
L
VL
SIG
I
M
G
C
LTPYATGPG
V
IIYG
C
GY
VKSK
DYWRLGAIFGVI
Y
ISM
LL
L
VG
WP
IL
A
M
W
N
fig|362663.9.peg.647
Escherichia coli 536
M
APL
V
V
MG
VM
F
LIP
V
P
D
G
M
PPQ
AW
H
YFAVF
V
A
M
IVG
M
ILEP
I
P
AT
AI
SF
IAVTI
CV
I
G
S
NY
LLF
DAKE
LA
D
P
A
F
NAQ
K
QA
L
K
W
G
L
A
GFSS
T
T
V
WLVF
G
AF
I
F
AL
GYE
V
S
GLGRRIAL
F
LVK
F
MG
K
RTL
T
LGYA
I
V
I
I
D
I
L
LAP
F
TPSNTAR
T
GG
T
V
F
P
V
I
K
NLPPL
FK
S
F
PND
P
S
A
RRIG
G
YLMWM
MV
I
S
T
SL
S
S
S
MF
V
T
GA
APN
V
L
G
L
EF
V
SK
I
A
G
I
--
QISW
L
Q
WFL
CF
LP
V
G
V
ILL
I
I
A
PWL
S
YVLY
K
PEI
T
HS
E
E
V
A
TWA
GD
EL
KT
MG
A
L
TR
RE
W
T
L
I
GL
V
L
L
S
L
G
LW
V
FG
SEV
--
I
N
AT
A
VG
LL
A
V
S
LML
A
--
L
H
V
V
P
WKDI
T
R
YN
S
AWNTL
V
N
LA
T
L
V
V
M
A
N
GLT
RS
GFI
D
WFA
NTMST
HL
E
G
F
SP
NA
----
TVI
VL
V
L
VFY
FA
H
Y
L
FAS
L
SA
H
T
A
T
MLPV
IL
A
V
G
KGI
P
---
G
V
P
M
EQL
C
I
L
L
VL
SIG
I
M
G
C
LTPYATGPG
V
IIYG
C
GY
VKSK
DYWRLGAIFGVI
Y
ISM
LL
L
VG
WP
IL
A
M
W
N
fig|525281.3.peg.2325
Escherichia coli 83972
M
APL
V
V
MG
VM
F
LIP
V
P
D
G
M
PPQ
AW
H
YFAVF
V
A
M
IVG
M
ILEP
I
P
AT
AI
SF
IAVTI
CV
I
G
S
NY
LLF
DAKE
LA
D
P
A
F
NAQ
K
QA
L
K
W
G
L
A
GFSS
T
T
V
WLVF
G
AF
I
F
AL
GYE
V
S
GLGRRIAL
F
LVK
F
MG
K
RTL
T
LGYA
I
V
I
I
D
I
L
LAP
F
TPSNTAR
T
GG
T
V
F
P
V
I
K
NLPPL
FK
S
F
PND
P
S
A
RRIG
G
YLMWM
MV
I
S
T
SL
S
S
S
MF
V
T
GA
APN
V
L
G
L
EF
V
SK
I
A
G
I
--
QISW
L
Q
WFL
CF
LP
V
G
V
ILL
I
I
A
PWL
S
YVLY
K
PEI
T
HS
E
E
V
A
TWA
GD
EL
KT
MG
A
L
TR
RE
W
T
L
I
GL
V
L
L
S
L
G
LW
V
FG
SEV
--
I
N
AT
A
VG
LL
A
V
S
LML
A
--
L
H
V
V
P
WKDI
T
R
YN
S
AWNTL
V
N
LA
T
L
V
V
M
A
N
GLT
RS
GFI
D
WFA
NTMST
HL
E
G
F
SP
NA
----
TVI
VL
V
L
VFY
FA
H
Y
L
FAS
L
SA
H
T
A
T
MLPV
IL
A
V
G
KGI
P
---
G
V
P
M
EQL
C
I
L
L
VL
SIG
I
M
G
C
LTPYATGPG
V
IIYG
C
GY
VKSK
DYWRLGAIFGVI
Y
ISM
LL
L
VG
WP
IL
A
M
W
N
fig|655817.3.peg.707
Escherichia coli ABU 83972
M
APL
V
V
MG
VM
F
LIP
V
P
D
G
M
PPQ
AW
H
YFAVF
V
A
M
IVG
M
ILEP
I
P
AT
AI
SF
IAVTI
CV
I
G
S
NY
LLF
DAKE
LA
D
P
A
F
NAQ
K
QA
L
K
W
G
L
A
GFSS
T
T
V
WLVF
G
AF
I
F
AL
GYE
V
S
GLGRRIAL
F
LVK
F
MG
K
RTL
T
LGYA
I
V
I
I
D
I
L
LAP
F
TPSNTAR
T
GG
T
V
F
P
V
I
K
NLPPL
FK
S
F
PND
P
S
A
RRIG
G
YLMWM
MV
I
S
T
SL
S
S
S
MF
V
T
GA
APN
V
L
G
L
EF
V
SK
I
A
G
I
--
QISW
L
Q
WFL
CF
LP
V
G
V
ILL
I
I
A
PWL
S
YVLY
K
PEI
T
HS
E
E
V
A
TWA
GD
EL
KT
MG
A
L
TR
RE
W
T
L
I
GL
V
L
L
S
L
G
LW
V
FG
SEV
--
I
N
AT
A
VG
LL
A
V
S
LML
A
--
L
H
V
V
P
WKDI
T
R
YN
S
AWNTL
V
N
LA
T
L
V
V
M
A
N
GLT
RS
GFI
D
WFA
NTMST
HL
E
G
F
SP
NA
----
TVI
VL
V
L
VFY
FA
H
Y
L
FAS
L
SA
H
T
A
T
MLPV
IL
A
V
G
KGI
P
---
G
V
P
M
EQL
C
I
L
L
VL
SIG
I
M
G
C
LTPYATGPG
V
IIYG
C
GY
VKSK
DYWRLGAIFGVI
Y
ISM
LL
L
VG
WP
IL
A
M
W
N
fig|405955.13.peg.591
Escherichia coli APEC O1
M
APL
V
V
MG
VM
F
LIP
V
P
D
G
M
PPQ
AW
H
YFAVF
V
A
M
IVG
M
ILEP
I
P
AT
AI
SF
IAVTI
CV
I
G
S
NY
LLF
DAKE
LA
D
P
A
F
NAQ
K
QA
L
K
W
G
L
A
GFSS
T
T
V
WLVF
G
AF
I
F
AL
GYE
V
S
GLGRRIAL
F
LVK
F
MG
K
RTL
T
LGYA
I
V
I
I
D
I
L
LAP
F
TPSNTAR
T
GG
T
V
F
P
V
I
K
NLPPL
FK
S
F
PND
P
S
A
RRIG
G
YLMWM
MV
I
S
T
SL
S
S
S
MF
V
T
GA
APN
V
L
G
L
EF
V
SK
I
A
G
I
--
QISW
L
Q
WFL
CF
LP
V
G
V
ILL
I
I
A
PWL
S
YVLY
K
PEI
T
HS
E
E
V
A
TWA
GD
EL
KT
MG
A
L
TR
RE
W
T
L
I
GL
V
L
L
S
L
G
LW
V
FG
SEV
--
I
N
AT
A
VG
LL
A
V
S
LML
A
--
L
H
V
V
P
WKDI
T
R
YN
S
AWNTL
V
N
LA
T
L
V
V
M
A
N
GLT
RS
GFI
D
WFA
NTMST
HL
E
G
F
SP
NA
----
TVI
VL
V
L
VFY
FA
H
Y
L
FAS
L
SA
H
T
A
T
MLPV
IL
A
V
G
KGI
P
---
G
V
P
M
EQL
C
I
L
L
VL
SIG
I
M
G
C
LTPYATGPG
V
IIYG
C
GY
VKSK
DYWRLGAIFGVI
Y
ISM
LL
L
VG
WP
IL
A
M
W
N
fig|199310.4.peg.665
Escherichia coli CFT073
M
APL
V
V
MG
VM
F
LIP
V
P
D
G
M
PPQ
AW
H
YFAVF
V
A
M
IVG
M
ILEP
I
P
AT
AI
SF
IAVTI
CV
I
G
S
NY
LLF
DAKE
LA
D
P
A
F
NAQ
K
QA
L
K
W
G
L
A
GFSS
T
T
V
WLVF
G
AF
I
F
AL
GYE
V
S
GLGRRIAL
F
LVK
F
MG
K
RTL
T
LGYA
I
V
I
I
D
I
L
LAP
F
TPSNTAR
T
GG
T
V
F
P
V
I
K
NLPPL
FK
S
F
PND
P
S
A
RRIG
G
YLMWM
MV
I
S
T
SL
S
S
S
MF
V
T
GA
APN
V
L
G
L
EF
V
SK
I
A
G
I
--
QISW
L
Q
WFL
CF
LP
V
G
V
ILL
I
I
A
PWL
S
YVLY
K
PEI
T
HS
E
E
V
A
TWA
GD
EL
KT
MG
A
L
TR
RE
W
T
L
I
GL
V
L
L
S
L
G
LW
V
FG
SEV
--
I
N
AT
A
VG
LL
A
V
S
LML
A
--
L
H
V
V
P
WKDI
T
R
YN
S
AWNTL
V
N
LA
T
L
V
V
M
A
N
GLT
RS
GFI
D
WFA
NTMST
HL
E
G
F
SP
NA
----
TVI
VL
V
L
VFY
FA
H
Y
L
FAS
L
SA
H
T
A
T
MLPV
IL
A
V
G
KGI
P
---
G
V
P
M
EQL
C
I
L
L
VL
SIG
I
M
G
C
LTPYATGPG
V
IIYG
C
GY
VKSK
DYWRLGAIFGVI
Y
ISM
LL
L
VG
WP
IL
A
M
W
N
fig|340197.5.peg.2569
Escherichia coli F11
M
APL
V
V
MG
VM
F
LIP
V
P
D
G
M
PPQ
AW
H
YFAVF
V
A
M
IVG
M
ILEP
I
P
AT
AI
SF
IAVTI
CV
I
G
S
NY
LLF
DAKE
LA
D
P
A
F
NAQ
K
QA
L
K
W
G
L
A
GFSS
T
T
V
WLVF
G
AF
I
F
AL
GYE
V
S
GLGRRIAL
F
LVK
F
MG
K
RTL
T
LGYA
I
V
I
I
D
I
L
LAP
F
TPSNTAR
T
GG
T
V
F
P
V
I
K
NLPPL
FK
S
F
PND
P
S
A
RRIG
G
YLMWM
MV
I
S
T
SL
S
S
S
MF
V
T
GA
APN
V
L
G
L
EF
V
SK
I
A
G
I
--
QISW
L
Q
WFL
CF
LP
V
G
V
ILL
I
I
A
PWL
S
YVLY
K
PEI
T
HS
E
E
V
A
TWA
GD
EL
KT
MG
A
L
TR
RE
W
T
L
I
GL
V
L
L
S
L
G
LW
V
FG
SEV
--
I
N
AT
A
VG
LL
A
V
S
LML
A
--
L
H
V
V
P
WKDI
T
R
YN
S
AWNTL
V
N
LA
T
L
V
V
M
A
N
GLT
RS
GFI
D
WFA
NTMST
HL
E
G
F
SP
NA
----
TVI
VL
V
L
VFY
FA
H
Y
L
FAS
L
SA
H
T
A
T
MLPV
IL
A
V
G
KGI
P
---
G
V
P
M
EQL
C
I
L
L
VL
SIG
I
M
G
C
LTPYATGPG
V
IIYG
C
GY
VKSK
DYWRLGAIFGVI
Y
ISM
LL
L
VG
WP
IL
A
M
W
N
fig|585057.4.peg.627
Escherichia coli IAI39
M
APL
V
V
MG
VM
F
LIP
V
P
D
G
M
PPQ
AW
H
YFAVF
V
A
M
IVG
M
ILEP
I
P
AT
AI
SF
IAVTI
CV
I
G
S
NY
LLF
DAKE
LA
D
P
A
F
NAQ
K
QA
L
K
W
G
L
A
GFSS
T
T
V
WLVF
G
AF
I
F
AL
GYE
V
S
GLGRRIAL
F
LVK
F
MG
K
RTL
T
LGYA
I
V
I
I
D
I
L
LAP
F
TPSNTAR
T
GG
T
V
F
P
V
I
K
NLPPL
FK
S
F
PND
P
S
A
RRIG
G
YLMWM
MV
I
S
T
SL
S
S
S
MF
V
T
GA
APN
V
L
G
L
EF
V
SK
I
A
G
I
--
QISW
L
Q
WFL
CF
LP
V
G
V
ILL
I
I
A
PWL
S
YVLY
K
PEI
T
HS
E
E
V
A
TWA
GD
EL
KT
MG
A
L
TR
RE
W
T
L
I
GL
V
L
L
S
L
G
LW
V
FG
SEV
--
I
N
AT
A
VG
LL
A
V
S
LML
A
--
L
H
V
V
P
WKDI
T
R
YN
S
AWNTL
V
N
LA
T
L
V
V
M
A
N
GLT
RS
GFI
D
WFA
NTMST
HL
E
G
F
SP
NA
----
TVI
VL
V
L
VFY
FA
H
Y
L
FAS
L
SA
H
T
A
T
MLPV
IL
A
V
G
KGI
P
---
G
V
P
M
EQL
C
I
L
L
VL
SIG
I
M
G
C
LTPYATGPG
V
IIYG
C
GY
VKSK
DYWRLGAIFGVI
Y
ISM
LL
L
VG
WP
IL
A
M
W
N
fig|585057.6.peg.625
Escherichia coli IAI39
M
APL
V
V
MG
VM
F
LIP
V
P
D
G
M
PPQ
AW
H
YFAVF
V
A
M
IVG
M
ILEP
I
P
AT
AI
SF
IAVTI
CV
I
G
S
NY
LLF
DAKE
LA
D
P
A
F
NAQ
K
QA
L
K
W
G
L
A
GFSS
T
T
V
WLVF
G
AF
I
F
AL
GYE
V
S
GLGRRIAL
F
LVK
F
MG
K
RTL
T
LGYA
I
V
I
I
D
I
L
LAP
F
TPSNTAR
T
GG
T
V
F
P
V
I
K
NLPPL
FK
S
F
PND
P
S
A
RRIG
G
YLMWM
MV
I
S
T
SL
S
S
S
MF
V
T
GA
APN
V
L
G
L
EF
V
SK
I
A
G
I
--
QISW
L
Q
WFL
CF
LP
V
G
V
ILL
I
I
A
PWL
S
YVLY
K
PEI
T
HS
E
E
V
A
TWA
GD
EL
KT
MG
A
L
TR
RE
W
T
L
I
GL
V
L
L
S
L
G
LW
V
FG
SEV
--
I
N
AT
A
VG
LL
A
V
S
LML
A
--
L
H
V
V
P
WKDI
T
R
YN
S
AWNTL
V
N
LA
T
L
V
V
M
A
N
GLT
RS
GFI
D
WFA
NTMST
HL
E
G
F
SP
NA
----
TVI
VL
V
L
VFY
FA
H
Y
L
FAS
L
SA
H
T
A
T
MLPV
IL
A
V
G
KGI
P
---
G
V
P
M
EQL
C
I
L
L
VL
SIG
I
M
G
C
LTPYATGPG
V
IIYG
C
GY
VKSK
DYWRLGAIFGVI
Y
ISM
LL
L
VG
WP
IL
A
M
W
N
fig|714962.3.peg.639
Escherichia coli IHE3034
M
APL
V
V
MG
VM
F
LIP
V
P
D
G
M
PPQ
AW
H
YFAVF
V
A
M
IVG
M
ILEP
I
P
AT
AI
SF
IAVTI
CV
I
G
S
NY
LLF
DAKE
LA
D
P
A
F
NAQ
K
QA
L
K
W
G
L
A
GFSS
T
T
V
WLVF
G
AF
I
F
AL
GYE
V
S
GLGRRIAL
F
LVK
F
MG
K
RTL
T
LGYA
I
V
I
I
D
I
L
LAP
F
TPSNTAR
T
GG
T
V
F
P
V
I
K
NLPPL
FK
S
F
PND
P
S
A
RRIG
G
YLMWM
MV
I
S
T
SL
S
S
S
MF
V
T
GA
APN
V
L
G
L
EF
V
SK
I
A
G
I
--
QISW
L
Q
WFL
CF
LP
V
G
V
ILL
I
I
A
PWL
S
YVLY
K
PEI
T
HS
E
E
V
A
TWA
GD
EL
KT
MG
A
L
TR
RE
W
T
L
I
GL
V
L
L
S
L
G
LW
V
FG
SEV
--
I
N
AT
A
VG
LL
A
V
S
LML
A
--
L
H
V
V
P
WKDI
T
R
YN
S
AWNTL
V
N
LA
T
L
V
V
M
A
N
GLT
RS
GFI
D
WFA
NTMST
HL
E
G
F
SP
NA
----
TVI
VL
V
L
VFY
FA
H
Y
L
FAS
L
SA
H
T
A
T
MLPV
IL
A
V
G
KGI
P
---
G
V
P
M
EQL
C
I
L
L
VL
SIG
I
M
G
C
LTPYATGPG
V
IIYG
C
GY
VKSK
DYWRLGAIFGVI
Y
ISM
LL
L
VG
WP
IL
A
M
W
N
fig|656417.3.peg.736
Escherichia coli M605
M
APL
V
V
MG
VM
F
LIP
V
P
D
G
M
PPQ
AW
H
YFAVF
V
A
M
IVG
M
ILEP
I
P
AT
AI
SF
IAVTI
CV
I
G
S
NY
LLF
DAKE
LA
D
P
A
F
NAQ
K
QA
L
K
W
G
L
A
GFSS
T
T
V
WLVF
G
AF
I
F
AL
GYE
V
S
GLGRRIAL
F
LVK
F
MG
K
RTL
T
LGYA
I
V
I
I
D
I
L
LAP
F
TPSNTAR
T
GG
T
V
F
P
V
I
K
NLPPL
FK
S
F
PND
P
S
A
RRIG
G
YLMWM
MV
I
S
T
SL
S
S
S
MF
V
T
GA
APN
V
L
G
L
EF
V
SK
I
A
G
I
--
QISW
L
Q
WFL
CF
LP
V
G
V
ILL
I
I
A
PWL
S
YVLY
K
PEI
T
HS
E
E
V
A
TWA
GD
EL
KT
MG
A
L
TR
RE
W
T
L
I
GL
V
L
L
S
L
G
LW
V
FG
SEV
--
I
N
AT
A
VG
LL
A
V
S
LML
A
--
L
H
V
V
P
WKDI
T
R
YN
S
AWNTL
V
N
LA
T
L
V
V
M
A
N
GLT
RS
GFI
D
WFA
NTMST
HL
E
G
F
SP
NA
----
TVI
VL
V
L
VFY
FA
H
Y
L
FAS
L
SA
H
T
A
T
MLPV
IL
A
V
G
KGI
P
---
G
V
P
M
EQL
C
I
L
L
VL
SIG
I
M
G
C
LTPYATGPG
V
IIYG
C
GY
VKSK
DYWRLGAIFGVI
Y
ISM
LL
L
VG
WP
IL
A
M
W
N
fig|749546.3.peg.3440
Escherichia coli MS 185-1
M
APL
V
V
MG
VM
F
LIP
V
P
D
G
M
PPQ
AW
H
YFAVF
V
A
M
IVG
M
ILEP
I
P
AT
AI
SF
IAVTI
CV
I
G
S
NY
LLF
DAKE
LA
D
P
A
F
NAQ
K
QA
L
K
W
G
L
A
GFSS
T
T
V
WLVF
G
AF
I
F
AL
GYE
V
S
GLGRRIAL
F
LVK
F
MG
K
RTL
T
LGYA
I
V
I
I
D
I
L
LAP
F
TPSNTAR
T
GG
T
V
F
P
V
I
K
NLPPL
FK
S
F
PND
P
S
A
RRIG
G
YLMWM
MV
I
S
T
SL
S
S
S
MF
V
T
GA
APN
V
L
G
L
EF
V
SK
I
A
G
I
--
QISW
L
Q
WFL
CF
LP
V
G
V
ILL
I
I
A
PWL
S
YVLY
K
PEI
T
HS
E
E
V
A
TWA
GD
EL
KT
MG
A
L
TR
RE
W
T
L
I
GL
V
L
L
S
L
G
LW
V
FG
SEV
--
I
N
AT
A
VG
LL
A
V
S
LML
A
--
L
H
V
V
P
WKDI
T
R
YN
S
AWNTL
V
N
LA
T
L
V
V
M
A
N
GLT
RS
GFI
D
WFA
NTMST
HL
E
G
F
SP
NA
----
TVI
VL
V
L
VFY
FA
H
Y
L
FAS
L
SA
H
T
A
T
MLPV
IL
A
V
G
KGI
P
---
G
V
P
M
EQL
C
I
L
L
VL
SIG
I
M
G
C
LTPYATGPG
V
IIYG
C
GY
VKSK
DYWRLGAIFGVI
Y
ISM
LL
L
VG
WP
IL
A
M
W
N
fig|749550.3.peg.4834
Escherichia coli MS 200-1
M
APL
V
V
MG
VM
F
LIP
V
P
D
G
M
PPQ
AW
H
YFAVF
V
A
M
IVG
M
ILEP
I
P
AT
AI
SF
IAVTI
CV
I
G
S
NY
LLF
DAKE
LA
D
P
A
F
NAQ
K
QA
L
K
W
G
L
A
GFSS
T
T
V
WLVF
G
AF
I
F
AL
GYE
V
S
GLGRRIAL
F
LVK
F
MG
K
RTL
T
LGYA
I
V
I
I
D
I
L
LAP
F
TPSNTAR
T
GG
T
V
F
P
V
I
K
NLPPL
FK
S
F
PND
P
S
A
RRIG
G
YLMWM
MV
I
S
T
SL
S
S
S
MF
V
T
GA
APN
V
L
G
L
EF
V
SK
I
A
G
I
--
QISW
L
Q
WFL
CF
LP
V
G
V
ILL
I
I
A
PWL
S
YVLY
K
PEI
T
HS
E
E
V
A
TWA
GD
EL
KT
MG
A
L
TR
RE
W
T
L
I
GL
V
L
L
S
L
G
LW
V
FG
SEV
--
I
N
AT
A
VG
LL
A
V
S
LML
A
--
L
H
V
V
P
WKDI
T
R
YN
S
AWNTL
V
N
LA
T
L
V
V
M
A
N
GLT
RS
GFI
D
WFA
NTMST
HL
E
G
F
SP
NA
----
TVI
VL
V
L
VFY
FA
H
Y
L
FAS
L
SA
H
T
A
T
MLPV
IL
A
V
G
KGI
P
---
G
V
P
M
EQL
C
I
L
L
VL
SIG
I
M
G
C
LTPYATGPG
V
IIYG
C
GY
VKSK
DYWRLGAIFGVI
Y
ISM
LL
L
VG
WP
IL
A
M
W
N
fig|749527.3.peg.4190
Escherichia coli MS 21-1
M
APL
V
V
MG
VM
F
LIP
V
P
D
G
M
PPQ
AW
H
YFAVF
V
A
M
IVG
M
ILEP
I
P
AT
AI
SF
IAVTI
CV
I
G
S
NY
LLF
DAKE
LA
D
P
A
F
NAQ
K
QA
L
K
W
G
L
A
GFSS
T
T
V
WLVF
G
AF
I
F
AL
GYE
V
S
GLGRRIAL
F
LVK
F
MG
K
RTL
T
LGYA
I
V
I
I
D
I
L
LAP
F
TPSNTAR
T
GG
T
V
F
P
V
I
K
NLPPL
FK
S
F
PND
P
S
A
RRIG
G
YLMWM
MV
I
S
T
SL
S
S
S
MF
V
T
GA
APN
V
L
G
L
EF
V
SK
I
A
G
I
--
QISW
L
Q
WFL
CF
LP
V
G
V
ILL
I
I
A
PWL
S
YVLY
K
PEI
T
HS
E
E
V
A
TWA
GD
EL
KT
MG
A
L
TR
RE
W
T
L
I
GL
V
L
L
S
L
G
LW
V
FG
SEV
--
I
N
AT
A
VG
LL
A
V
S
LML
A
--
L
H
V
V
P
WKDI
T
R
YN
S
AWNTL
V
N
LA
T
L
V
V
M
A
N
GLT
RS
GFI
D
WFA
NTMST
HL
E
G
F
SP
NA
----
TVI
VL
V
L
VFY
FA
H
Y
L
FAS
L
SA
H
T
A
T
MLPV
IL
A
V
G
KGI
P
---
G
V
P
M
EQL
C
I
L
L
VL
SIG
I
M
G
C
LTPYATGPG
V
IIYG
C
GY
VKSK
DYWRLGAIFGVI
Y
ISM
LL
L
VG
WP
IL
A
M
W
N
fig|749528.3.peg.4022
Escherichia coli MS 45-1
M
APL
V
V
MG
VM
F
LIP
V
P
D
G
M
PPQ
AW
H
YFAVF
V
A
M
IVG
M
ILEP
I
P
AT
AI
SF
IAVTI
CV
I
G
S
NY
LLF
DAKE
LA
D
P
A
F
NAQ
K
QA
L
K
W
G
L
A
GFSS
T
T
V
WLVF
G
AF
I
F
AL
GYE
V
S
GLGRRIAL
F
LVK
F
MG
K
RTL
T
LGYA
I
V
I
I
D
I
L
LAP
F
TPSNTAR
T
GG
T
V
F
P
V
I
K
NLPPL
FK
S
F
PND
P
S
A
RRIG
G
YLMWM
MV
I
S
T
SL
S
S
S
MF
V
T
GA
APN
V
L
G
L
EF
V
SK
I
A
G
I
--
QISW
L
Q
WFL
CF
LP
V
G
V
ILL
I
I
A
PWL
S
YVLY
K
PEI
T
HS
E
E
V
A
TWA
GD
EL
KT
MG
A
L
TR
RE
W
T
L
I
GL
V
L
L
S
L
G
LW
V
FG
SEV
--
I
N
AT
A
VG
LL
A
V
S
LML
A
--
L
H
V
V
P
WKDI
T
R
YN
S
AWNTL
V
N
LA
T
L
V
V
M
A
N
GLT
RS
GFI
D
WFA
NTMST
HL
E
G
F
SP
NA
----
TVI
VL
V
L
VFY
FA
H
Y
L
FAS
L
SA
H
T
A
T
MLPV
IL
A
V
G
KGI
P
---
G
V
P
M
EQL
C
I
L
L
VL
SIG
I
M
G
C
LTPYATGPG
V
IIYG
C
GY
VKSK
DYWRLGAIFGVI
Y
ISM
LL
L
VG
WP
IL
A
M
W
N
fig|753642.3.peg.1043
Escherichia coli NC101
M
APL
V
V
MG
VM
F
LIP
V
P
D
G
M
PPQ
AW
H
YFAVF
V
A
M
IVG
M
ILEP
I
P
AT
AI
SF
IAVTI
CV
I
G
S
NY
LLF
DAKE
LA
D
P
A
F
NAQ
K
QA
L
K
W
G
L
A
GFSS
T
T
V
WLVF
G
AF
I
F
AL
GYE
V
S
GLGRRIAL
F
LVK
F
MG
K
RTL
T
LGYA
I
V
I
I
D
I
L
LAP
F
TPSNTAR
T
GG
T
V
F
P
V
I
K
NLPPL
FK
S
F
PND
P
S
A
RRIG
G
YLMWM
MV
I
S
T
SL
S
S
S
MF
V
T
GA
APN
V
L
G
L
EF
V
SK
I
A
G
I
--
QISW
L
Q
WFL
CF
LP
V
G
V
ILL
I
I
A
PWL
S
YVLY
K
PEI
T
HS
E
E
V
A
TWA
GD
EL
KT
MG
A
L
TR
RE
W
T
L
I
GL
V
L
L
S
L
G
LW
V
FG
SEV
--
I
N
AT
A
VG
LL
A
V
S
LML
A
--
L
H
V
V
P
WKDI
T
R
YN
S
AWNTL
V
N
LA
T
L
V
V
M
A
N
GLT
RS
GFI
D
WFA
NTMST
HL
E
G
F
SP
NA
----
TVI
VL
V
L
VFY
FA
H
Y
L
FAS
L
SA
H
T
A
T
MLPV
IL
A
V
G
KGI
P
---
G
V
P
M
EQL
C
I
L
L
VL
SIG
I
M
G
C
LTPYATGPG
V
IIYG
C
GY
VKSK
DYWRLGAIFGVI
Y
ISM
LL
L
VG
WP
IL
A
M
W
N
fig|685038.3.peg.558
Escherichia coli O83:H1 str. NRG 857C
M
APL
V
V
MG
VM
F
LIP
V
P
D
G
M
PPQ
AW
H
YFAVF
V
A
M
IVG
M
ILEP
I
P
AT
AI
SF
IAVTI
CV
I
G
S
NY
LLF
DAKE
LA
D
P
A
F
NAQ
K
QA
L
K
W
G
L
A
GFSS
T
T
V
WLVF
G
AF
I
F
AL
GYE
V
S
GLGRRIAL
F
LVK
F
MG
K
RTL
T
LGYA
I
V
I
I
D
I
L
LAP
F
TPSNTAR
T
GG
T
V
F
P
V
I
K
NLPPL
FK
S
F
PND
P
S
A
RRIG
G
YLMWM
MV
I
S
T
SL
S
S
S
MF
V
T
GA
APN
V
L
G
L
EF
V
SK
I
A
G
I
--
QISW
L
Q
WFL
CF
LP
V
G
V
ILL
I
I
A
PWL
S
YVLY
K
PEI
T
HS
E
E
V
A
TWA
GD
EL
KT
MG
A
L
TR
RE
W
T
L
I
GL
V
L
L
S
L
G
LW
V
FG
SEV
--
I
N
AT
A
VG
LL
A
V
S
LML
A
--
L
H
V
V
P
WKDI
T
R
YN
S
AWNTL
V
N
LA
T
L
V
V
M
A
N
GLT
RS
GFI
D
WFA
NTMST
HL
E
G
F
SP
NA
----
TVI
VL
V
L
VFY
FA
H
Y
L
FAS
L
SA
H
T
A
T
MLPV
IL
A
V
G
KGI
P
---
G
V
P
M
EQL
C
I
L
L
VL
SIG
I
M
G
C
LTPYATGPG
V
IIYG
C
GY
VKSK
DYWRLGAIFGVI
Y
ISM
LL
L
VG
WP
IL
A
M
W
N
fig|585035.6.peg.648
Escherichia coli S88
M
APL
V
V
MG
VM
F
LIP
V
P
D
G
M
PPQ
AW
H
YFAVF
V
A
M
IVG
M
ILEP
I
P
AT
AI
SF
IAVTI
CV
I
G
S
NY
LLF
DAKE
LA
D
P
A
F
NAQ
K
QA
L
K
W
G
L
A
GFSS
T
T
V
WLVF
G
AF
I
F
AL
GYE
V
S
GLGRRIAL
F
LVK
F
MG
K
RTL
T
LGYA
I
V
I
I
D
I
L
LAP
F
TPSNTAR
T
GG
T
V
F
P
V
I
K
NLPPL
FK
S
F
PND
P
S
A
RRIG
G
YLMWM
MV
I
S
T
SL
S
S
S
MF
V
T
GA
APN
V
L
G
L
EF
V
SK
I
A
G
I
--
QISW
L
Q
WFL
CF
LP
V
G
V
ILL
I
I
A
PWL
S
YVLY
K
PEI
T
HS
E
E
V
A
TWA
GD
EL
KT
MG
A
L
TR
RE
W
T
L
I
GL
V
L
L
S
L
G
LW
V
FG
SEV
--
I
N
AT
A
VG
LL
A
V
S
LML
A
--
L
H
V
V
P
WKDI
T
R
YN
S
AWNTL
V
N
LA
T
L
V
V
M
A
N
GLT
RS
GFI
D
WFA
NTMST
HL
E
G
F
SP
NA
----
TVI
VL
V
L
VFY
FA
H
Y
L
FAS
L
SA
H
T
A
T
MLPV
IL
A
V
G
KGI
P
---
G
V
P
M
EQL
C
I
L
L
VL
SIG
I
M
G
C
LTPYATGPG
V
IIYG
C
GY
VKSK
DYWRLGAIFGVI
Y
ISM
LL
L
VG
WP
IL
A
M
W
N
fig|431946.3.peg.573
Escherichia coli SE15
M
APL
V
V
MG
VM
F
LIP
V
P
D
G
M
PPQ
AW
H
YFAVF
V
A
M
IVG
M
ILEP
I
P
AT
AI
SF
IAVTI
CV
I
G
S
NY
LLF
DAKE
LA
D
P
A
F
NAQ
K
QA
L
K
W
G
L
A
GFSS
T
T
V
WLVF
G
AF
I
F
AL
GYE
V
S
GLGRRIAL
F
LVK
F
MG
K
RTL
T
LGYA
I
V
I
I
D
I
L
LAP
F
TPSNTAR
T
GG
T
V
F
P
V
I
K
NLPPL
FK
S
F
PND
P
S
A
RRIG
G
YLMWM
MV
I
S
T
SL
S
S
S
MF
V
T
GA
APN
V
L
G
L
EF
V
SK
I
A
G
I
--
QISW
L
Q
WFL
CF
LP
V
G
V
ILL
I
I
A
PWL
S
YVLY
K
PEI
T
HS
E
E
V
A
TWA
GD
EL
KT
MG
A
L
TR
RE
W
T
L
I
GL
V
L
L
S
L
G
LW
V
FG
SEV
--
I
N
AT
A
VG
LL
A
V
S
LML
A
--
L
H
V
V
P
WKDI
T
R
YN
S
AWNTL
V
N
LA
T
L
V
V
M
A
N
GLT
RS
GFI
D
WFA
NTMST
HL
E
G
F
SP
NA
----
TVI
VL
V
L
VFY
FA
H
Y
L
FAS
L
SA
H
T
A
T
MLPV
IL
A
V
G
KGI
P
---
G
V
P
M
EQL
C
I
L
L
VL
SIG
I
M
G
C
LTPYATGPG
V
IIYG
C
GY
VKSK
DYWRLGAIFGVI
Y
ISM
LL
L
VG
WP
IL
A
M
W
N
fig|656437.3.peg.690
Escherichia coli TA143
M
APL
V
V
MG
VM
F
LIP
V
P
D
G
M
PPQ
AW
H
YFAVF
V
A
M
IVG
M
ILEP
I
P
AT
AI
SF
IAVTI
CV
I
G
S
NY
LLF
DAKE
LA
D
P
A
F
NAQ
K
QA
L
K
W
G
L
A
GFSS
T
T
V
WLVF
G
AF
I
F
AL
GYE
V
S
GLGRRIAL
F
LVK
F
MG
K
RTL
T
LGYA
I
V
I
I
D
I
L
LAP
F
TPSNTAR
T
GG
T
V
F
P
V
I
K
NLPPL
FK
S
F
PND
P
S
A
RRIG
G
YLMWM
MV
I
S
T
SL
S
S
S
MF
V
T
GA
APN
V
L
G
L
EF
V
SK
I
A
G
I
--
QISW
L
Q
WFL
CF
LP
V
G
V
ILL
I
I
A
PWL
S
YVLY
K
PEI
T
HS
E
E
V
A
TWA
GD
EL
KT
MG
A
L
TR
RE
W
T
L
I
GL
V
L
L
S
L
G
LW
V
FG
SEV
--
I
N
AT
A
VG
LL
A
V
S
LML
A
--
L
H
V
V
P
WKDI
T
R
YN
S
AWNTL
V
N
LA
T
L
V
V
M
A
N
GLT
RS
GFI
D
WFA
NTMST
HL
E
G
F
SP
NA
----
TVI
VL
V
L
VFY
FA
H
Y
L
FAS
L
SA
H
T
A
T
MLPV
IL
A
V
G
KGI
P
---
G
V
P
M
EQL
C
I
L
L
VL
SIG
I
M
G
C
LTPYATGPG
V
IIYG
C
GY
VKSK
DYWRLGAIFGVI
Y
ISM
LL
L
VG
WP
IL
A
M
W
N
fig|656440.3.peg.471
Escherichia coli TA206
M
APL
V
V
MG
VM
F
LIP
V
P
D
G
M
PPQ
AW
H
YFAVF
V
A
M
IVG
M
ILEP
I
P
AT
AI
SF
IAVTI
CV
I
G
S
NY
LLF
DAKE
LA
D
P
A
F
NAQ
K
QA
L
K
W
G
L
A
GFSS
T
T
V
WLVF
G
AF
I
F
AL
GYE
V
S
GLGRRIAL
F
LVK
F
MG
K
RTL
T
LGYA
I
V
I
I
D
I
L
LAP
F
TPSNTAR
T
GG
T
V
F
P
V
I
K
NLPPL
FK
S
F
PND
P
S
A
RRIG
G
YLMWM
MV
I
S
T
SL
S
S
S
MF
V
T
GA
APN
V
L
G
L
EF
V
SK
I
A
G
I
--
QISW
L
Q
WFL
CF
LP
V
G
V
ILL
I
I
A
PWL
S
YVLY
K
PEI
T
HS
E
E
V
A
TWA
GD
EL
KT
MG
A
L
TR
RE
W
T
L
I
GL
V
L
L
S
L
G
LW
V
FG
SEV
--
I
N
AT
A
VG
LL
A
V
S
LML
A
--
L
H
V
V
P
WKDI
T
R
YN
S
AWNTL
V
N
LA
T
L
V
V
M
A
N
GLT
RS
GFI
D
WFA
NTMST
HL
E
G
F
SP
NA
----
TVI
VL
V
L
VFY
FA
H
Y
L
FAS
L
SA
H
T
A
T
MLPV
IL
A
V
G
KGI
P
---
G
V
P
M
EQL
C
I
L
L
VL
SIG
I
M
G
C
LTPYATGPG
V
IIYG
C
GY
VKSK
DYWRLGAIFGVI
Y
ISM
LL
L
VG
WP
IL
A
M
W
N
fig|869729.3.peg.3091
Escherichia coli UM146
M
APL
V
V
MG
VM
F
LIP
V
P
D
G
M
PPQ
AW
H
YFAVF
V
A
M
IVG
M
ILEP
I
P
AT
AI
SF
IAVTI
CV
I
G
S
NY
LLF
DAKE
LA
D
P
A
F
NAQ
K
QA
L
K
W
G
L
A
GFSS
T
T
V
WLVF
G
AF
I
F
AL
GYE
V
S
GLGRRIAL
F
LVK
F
MG
K
RTL
T
LGYA
I
V
I
I
D
I
L
LAP
F
TPSNTAR
T
GG
T
V
F
P
V
I
K
NLPPL
FK
S
F
PND
P
S
A
RRIG
G
YLMWM
MV
I
S
T
SL
S
S
S
MF
V
T
GA
APN
V
L
G
L
EF
V
SK
I
A
G
I
--
QISW
L
Q
WFL
CF
LP
V
G
V
ILL
I
I
A
PWL
S
YVLY
K
PEI
T
HS
E
E
V
A
TWA
GD
EL
KT
MG
A
L
TR
RE
W
T
L
I
GL
V
L
L
S
L
G
LW
V
FG
SEV
--
I
N
AT
A
VG
LL
A
V
S
LML
A
--
L
H
V
V
P
WKDI
T
R
YN
S
AWNTL
V
N
LA
T
L
V
V
M
A
N
GLT
RS
GFI
D
WFA
NTMST
HL
E
G
F
SP
NA
----
TVI
VL
V
L
VFY
FA
H
Y
L
FAS
L
SA
H
T
A
T
MLPV
IL
A
V
G
KGI
P
---
G
V
P
M
EQL
C
I
L
L
VL
SIG
I
M
G
C
LTPYATGPG
V
IIYG
C
GY
VKSK
DYWRLGAIFGVI
Y
ISM
LL
L
VG
WP
IL
A
M
W
N
fig|364106.7.peg.720
Escherichia coli UTI89
M
APL
V
V
MG
VM
F
LIP
V
P
D
G
M
PPQ
AW
H
YFAVF
V
A
M
IVG
M
ILEP
I
P
AT
AI
SF
IAVTI
CV
I
G
S
NY
LLF
DAKE
LA
D
P
A
F
NAQ
K
QA
L
K
W
G
L
A
GFSS
T
T
V
WLVF
G
AF
I
F
AL
GYE
V
S
GLGRRIAL
F
LVK
F
MG
K
RTL
T
LGYA
I
V
I
I
D
I
L
LAP
F
TPSNTAR
T
GG
T
V
F
P
V
I
K
NLPPL
FK
S
F
PND
P
S
A
RRIG
G
YLMWM
MV
I
S
T
SL
S
S
S
MF
V
T
GA
APN
V
L
G
L
EF
V
SK
I
A
G
I
--
QISW
L
Q
WFL
CF
LP
V
G
V
ILL
I
I
A
PWL
S
YVLY
K
PEI
T
HS
E
E
V
A
TWA
GD
EL
KT
MG
A
L
TR
RE
W
T
L
I
GL
V
L
L
S
L
G
LW
V
FG
SEV
--
I
N
AT
A
VG
LL
A
V
S
LML
A
--
L
H
V
V
P
WKDI
T
R
YN
S
AWNTL
V
N
LA
T
L
V
V
M
A
N
GLT
RS
GFI
D
WFA
NTMST
HL
E
G
F
SP
NA
----
TVI
VL
V
L
VFY
FA
H
Y
L
FAS
L
SA
H
T
A
T
MLPV
IL
A
V
G
KGI
P
---
G
V
P
M
EQL
C
I
L
L
VL
SIG
I
M
G
C
LTPYATGPG
V
IIYG
C
GY
VKSK
DYWRLGAIFGVI
Y
ISM
LL
L
VG
WP
IL
A
M
W
N
fig|364106.8.peg.717
Escherichia coli UTI89
M
APL
V
V
MG
VM
F
LIP
V
P
D
G
M
PPQ
AW
H
YFAVF
V
A
M
IVG
M
ILEP
I
P
AT
AI
SF
IAVTI
CV
I
G
S
NY
LLF
DAKE
LA
D
P
A
F
NAQ
K
QA
L
K
W
G
L
A
GFSS
T
T
V
WLVF
G
AF
I
F
AL
GYE
V
S
GLGRRIAL
F
LVK
F
MG
K
RTL
T
LGYA
I
V
I
I
D
I
L
LAP
F
TPSNTAR
T
GG
T
V
F
P
V
I
K
NLPPL
FK
S
F
PND
P
S
A
RRIG
G
YLMWM
MV
I
S
T
SL
S
S
S
MF
V
T
GA
APN
V
L
G
L
EF
V
SK
I
A
G
I
--
QISW
L
Q
WFL
CF
LP
V
G
V
ILL
I
I
A
PWL
S
YVLY
K
PEI
T
HS
E
E
V
A
TWA
GD
EL
KT
MG
A
L
TR
RE
W
T
L
I
GL
V
L
L
S
L
G
LW
V
FG
SEV
--
I
N
AT
A
VG
LL
A
V
S
LML
A
--
L
H
V
V
P
WKDI
T
R
YN
S
AWNTL
V
N
LA
T
L
V
V
M
A
N
GLT
RS
GFI
D
WFA
NTMST
HL
E
G
F
SP
NA
----
TVI
VL
V
L
VFY
FA
H
Y
L
FAS
L
SA
H
T
A
T
MLPV
IL
A
V
G
KGI
P
---
G
V
P
M
EQL
C
I
L
L
VL
SIG
I
M
G
C
LTPYATGPG
V
IIYG
C
GY
VKSK
DYWRLGAIFGVI
Y
ISM
LL
L
VG
WP
IL
A
M
W
N
fig|562.376.peg.1999
Escherichia coli WV_060327
M
APL
V
V
MG
VM
F
LIP
V
P
D
G
M
PPQ
AW
H
YFAVF
V
A
M
IVG
M
ILEP
I
P
AT
AI
SF
IAVTI
CV
I
G
S
NY
LLF
DAKE
LA
D
P
A
F
NAQ
K
QA
L
K
W
G
L
A
GFSS
T
T
V
WLVF
G
AF
I
F
AL
GYE
V
S
GLGRRIAL
F
LVK
F
MG
K
RTL
T
LGYA
I
V
I
I
D
I
L
LAP
F
TPSNTAR
T
GG
T
V
F
P
V
I
K
NLPPL
FK
S
F
PND
P
S
A
RRIG
G
YLMWM
MV
I
S
T
SL
S
S
S
MF
V
T
GA
APN
V
L
G
L
EF
V
SK
I
A
G
I
--
QISW
L
Q
WFL
CF
LP
V
G
V
ILL
I
I
A
PWL
S
YVLY
K
PEI
T
HS
E
E
V
A
TWA
GD
EL
KT
MG
A
L
TR
RE
W
T
L
I
GL
V
L
L
S
L
G
LW
V
FG
SEV
--
I
N
AT
A
VG
LL
A
V
S
LML
A
--
L
H
V
V
P
WKDI
T
R
YN
S
AWNTL
V
N
LA
T
L
V
V
M
A
N
GLT
RS
GFI
D
WFA
NTMST
HL
E
G
F
SP
NA
----
TVI
VL
V
L
VFY
FA
H
Y
L
FAS
L
SA
H
T
A
T
MLPV
IL
A
V
G
KGI
P
---
G
V
P
M
EQL
C
I
L
L
VL
SIG
I
M
G
C
LTPYATGPG
V
IIYG
C
GY
VKSK
DYWRLGAIFGVI
Y
ISM
LL
L
VG
WP
IL
A
M
W
N
fig|585397.7.peg.611
Escherichia coli ED1a
M
APL
V
V
MG
VM
F
LIP
V
P
D
G
M
PPQ
AW
H
YFAVF
V
A
M
IVG
M
ILEP
I
P
AT
AI
SF
IAVTI
CV
I
G
S
NY
LLF
DAKE
LA
D
P
A
F
NAQ
K
QA
L
Q
W
G
L
A
GFSS
T
T
V
WLVF
G
AF
I
F
AL
GYE
V
S
GLGRRIAL
F
LVK
F
MG
K
RTL
T
LGYA
I
V
I
I
D
I
L
LAP
F
TPSNTAR
T
GG
T
V
F
P
V
I
K
NLPPL
FK
S
F
PND
P
S
A
RRIG
G
YLMWM
MV
I
S
T
SL
S
S
S
MF
V
T
GA
APN
V
L
G
L
EF
V
SK
I
A
G
I
--
QISW
L
Q
WFL
CF
LP
V
G
V
ILL
I
I
A
PWL
S
YVLY
K
PEI
T
HS
E
E
V
A
TWA
GD
EL
KT
MG
A
L
TR
RE
W
T
L
I
GL
V
L
L
S
L
G
LW
V
FG
SEV
--
I
N
AT
A
VG
LL
A
V
S
LML
A
--
L
H
V
V
P
WKDI
T
R
YN
S
AWNTL
V
N
LA
T
L
V
V
M
A
N
GLT
RS
GFI
D
WFA
NTMST
HL
E
G
F
SP
NA
----
TVI
VL
V
L
VFY
FA
H
Y
L
FAS
L
SA
H
T
A
T
MLPV
IL
A
V
G
KGI
P
---
G
V
P
M
EQL
C
I
L
L
VL
SIG
I
M
G
C
LTPYATGPG
V
IIYG
C
GY
VKSK
DYWRLGAIFGVI
Y
ISM
LL
L
VG
WP
IL
A
M
W
N
fig|585397.9.peg.613
Escherichia coli ED1a
M
APL
V
V
MG
VM
F
LIP
V
P
D
G
M
PPQ
AW
H
YFAVF
V
A
M
IVG
M
ILEP
I
P
AT
AI
SF
IAVTI
CV
I
G
S
NY
LLF
DAKE
LA
D
P
A
F
NAQ
K
QA
L
Q
W
G
L
A
GFSS
T
T
V
WLVF
G
AF
I
F
AL
GYE
V
S
GLGRRIAL
F
LVK
F
MG
K
RTL
T
LGYA
I
V
I
I
D
I
L
LAP
F
TPSNTAR
T
GG
T
V
F
P
V
I
K
NLPPL
FK
S
F
PND
P
S
A
RRIG
G
YLMWM
MV
I
S
T
SL
S
S
S
MF
V
T
GA
APN
V
L
G
L
EF
V
SK
I
A
G
I
--
QISW
L
Q
WFL
CF
LP
V
G
V
ILL
I
I
A
PWL
S
YVLY
K
PEI
T
HS
E
E
V
A
TWA
GD
EL
KT
MG
A
L
TR
RE
W
T
L
I
GL
V
L
L
S
L
G
LW
V
FG
SEV
--
I
N
AT
A
VG
LL
A
V
S
LML
A
--
L
H
V
V
P
WKDI
T
R
YN
S
AWNTL
V
N
LA
T
L
V
V
M
A
N
GLT
RS
GFI
D
WFA
NTMST
HL
E
G
F
SP
NA
----
TVI
VL
V
L
VFY
FA
H
Y
L
FAS
L
SA
H
T
A
T
MLPV
IL
A
V
G
KGI
P
---
G
V
P
M
EQL
C
I
L
L
VL
SIG
I
M
G
C
LTPYATGPG
V
IIYG
C
GY
VKSK
DYWRLGAIFGVI
Y
ISM
LL
L
VG
WP
IL
A
M
W
N
fig|155864.8.peg.664
Escherichia coli O157:H7 EDL933
M
APL
V
V
MG
VM
F
LIP
V
P
D
G
M
PPQ
AW
H
YFAVF
V
A
M
IVG
M
ILEP
I
P
AT
AI
SF
IAVTI
CV
I
G
S
NY
LLF
DAKE
LA
D
P
A
F
NAQ
K
QA
L
K
W
G
L
A
GFSS
T
T
V
WLVF
G
AF
I
F
AL
GYE
V
S
GLGRRIAL
F
LVK
F
MG
K
RTL
T
LGYA
I
V
I
I
D
I
L
LAP
F
TPSNTAR
T
GG
T
V
F
P
V
I
K
NLPPL
FK
S
F
PND
P
S
A
RRIG
G
YLMWM
MV
I
S
T
SL
S
S
S
MF
V
T
GA
APN
V
L
G
L
EF
V
SK
I
A
G
I
--
QISW
L
Q
WFL
CF
LP
V
G
V
ILL
I
I
A
PWL
S
YVLY
K
PEI
T
HS
E
E
V
A
TWA
GD
EL
KT
MG
A
L
TR
RE
W
T
L
I
GL
V
L
L
S
L
G
LW
V
FG
SEV
--
I
N
AT
A
VG
LL
A
V
S
LML
A
--
L
H
V
V
P
WKDI
T
R
YN
S
AWNTL
V
N
LA
T
L
V
V
M
A
N
GLT
RS
GFI
D
WFA
GTMST
HL
E
G
F
SP
NA
----
TVI
VL
V
L
VFY
FA
H
Y
L
FAS
L
SA
H
T
A
T
MLPV
IL
A
V
G
KXI
P
---
G
V
P
M
EQL
C
I
L
L
VL
SIG
I
M
G
C
LTPYATGPG
V
IIYG
C
GY
VKSK
DYWRLGAIFGVI
Y
ISM
LL
L
VG
WP
IL
A
M
W
N
fig|155864.1.peg.647
Escherichia coli O157:H7 EDL933 (12-487/487)
LAPL
V
V
MG
VM
F
LIP
V
P
D
G
M
PPQ
AW
H
YFAVF
V
A
M
IVG
M
ILEP
I
P
AT
AI
SF
IAVTI
CV
I
G
S
NY
LLF
DAKE
LA
D
P
A
F
NAQ
K
QA
L
K
W
G
L
A
GFSS
T
T
V
WLVF
G
AF
I
F
AL
GYE
V
S
GLGRRIAL
F
LVK
F
MG
K
RTL
T
LGYA
I
V
I
I
D
I
L
LAP
F
TPSNTAR
T
GG
T
V
F
P
V
I
K
NLPPL
FK
S
F
PND
P
S
A
RRIG
G
YLMWM
MV
I
S
T
SL
S
S
S
MF
V
T
GA
APN
V
L
G
L
EF
V
SK
I
A
G
I
--
QISW
L
Q
WFL
CF
LP
V
G
V
ILL
I
I
A
PWL
S
YVLY
K
PEI
T
HS
E
E
V
A
TWA
GD
EL
KT
MG
A
L
TR
RE
W
T
L
I
GL
V
L
L
S
L
G
LW
V
FG
SEV
--
I
N
AT
A
VG
LL
A
V
S
LML
A
--
L
H
V
V
P
WKDI
T
R
YN
S
AWNTL
V
N
LA
T
L
V
V
M
A
N
GLT
RS
GFI
D
WFA
GTMST
HL
E
G
F
SP
NA
----
TVI
VL
V
L
VFY
FA
H
Y
L
FAS
L
SA
H
T
A
T
MLPV
IL
A
V
G
KXI
P
---
G
V
P
M
EQL
C
I
L
L
VL
SIG
I
M
G
C
LTPYATGPG
V
IIYG
C
GY
VKSK
DYWRLGAIFGVI
Y
ISM
LL
L
VG
WP
IL
A
M
W
N
fig|656393.3.peg.1290
Escherichia coli H299
M
APL
V
V
MG
VM
F
LIP
V
P
D
G
M
PPQ
AW
H
YFAVF
V
A
M
IVG
M
ILEP
I
P
AT
AI
SF
IAVTI
CV
I
G
S
NY
LLF
NAKE
LA
D
P
A
F
NAQ
K
QA
L
K
W
G
L
A
GFSS
T
T
V
WLVF
G
AF
I
F
AL
GYE
V
S
GLGRRIAL
F
LVK
F
MG
K
RTL
T
LGYA
I
V
I
I
D
I
L
LAP
F
TPSNTAR
T
GG
T
V
F
P
V
I
K
NLPPL
FK
S
F
PND
P
S
A
RRIG
G
YLMWM
MV
I
S
T
SL
S
S
S
MF
V
T
GA
APN
V
L
G
L
EF
V
SK
I
A
G
I
--
QISW
L
Q
WFL
CF
LP
V
G
V
ILL
I
I
A
PWL
S
YVLY
K
PEI
T
HS
E
E
V
A
TWA
GD
EL
KT
MG
A
L
TR
RE
W
T
L
I
GL
V
L
L
S
L
G
LW
V
FG
SEV
--
I
N
AT
A
VG
LL
A
V
S
LML
A
--
L
H
V
V
P
WKDI
T
R
YN
S
AWNTL
V
N
LA
T
L
V
V
M
A
N
GLT
RS
GFI
D
WFA
NTMST
HL
E
G
F
SP
NA
----
TVI
VL
V
L
VFY
FA
H
Y
L
FAS
L
SA
H
T
A
T
MLPV
IL
A
V
G
KGI
P
---
G
V
P
M
EQL
C
I
L
L
VL
SIG
I
M
G
C
LTPYATGPG
V
IIYG
C
GY
VKSK
DYWRLGAIFGVI
Y
ISM
LL
L
VG
WP
IL
A
M
W
N
fig|670897.3.peg.777
Escherichia coli 2362-75
M
APL
V
V
MG
VM
F
LIP
V
P
D
G
M
PPQ
AW
H
YFAVF
V
A
M
IVG
M
ILEP
I
P
AT
AI
SF
IA
I
TI
CV
I
G
S
NY
LLF
DAKE
LA
D
P
A
F
NAQ
K
QA
L
K
W
G
L
A
GFSS
T
T
V
WLVF
G
AF
I
F
AL
GYE
V
S
GLGRRIAL
F
LVK
F
MG
K
RTL
T
LGYA
I
V
I
I
D
I
L
LAP
F
TPSNTAR
T
GG
T
V
F
P
V
I
K
NLPPL
FK
S
F
PND
P
S
A
RRIG
G
YLMWM
MV
I
S
T
SL
S
S
S
MF
V
T
GA
APN
V
L
G
L
EF
V
SK
I
A
G
I
--
QISW
L
Q
WFL
CF
LP
V
G
V
ILL
I
I
A
PWL
S
YVLY
K
PEI
T
HS
E
E
V
A
TWA
GD
EL
KT
MG
A
L
TR
RE
W
T
L
I
GL
V
L
L
S
L
G
LW
V
FG
SEV
--
I
N
AT
A
VG
LL
A
V
S
LML
A
--
L
H
V
V
P
WKDI
T
R
YN
S
AWNTL
V
N
LA
T
L
V
V
M
A
N
GLT
RS
GFI
D
WFA
NTMST
HL
E
G
F
SP
NA
----
TVI
VL
V
L
VFY
FA
H
Y
L
FAS
L
SA
H
T
A
T
MLPV
IL
A
V
G
KGI
P
---
G
V
P
M
EQL
C
I
L
L
VL
SIG
I
M
G
C
LTPYATGPG
V
IIYG
C
GY
VKSK
DYW
H
LGAIFGVI
Y
ISM
LL
L
VG
WP
IL
A
M
W
N
fig|574521.7.peg.552
Escherichia coli O127:H6 str. E2348/69
MG
VM
F
LIP
V
P
D
G
M
PPQ
AW
H
YFAVF
V
A
M
IVG
M
ILEP
I
P
AT
AI
SF
IAVTI
CV
I
G
S
NY
LLF
DAKE
LA
D
P
A
F
NAQ
K
QA
L
K
W
G
L
A
GFSS
T
T
V
WLVF
G
AF
I
F
AL
GYE
V
S
GLGRRIAL
F
LVK
F
MG
K
RTL
T
LGYA
I
V
I
I
D
I
L
LAP
F
TPSNTAR
T
GG
T
V
F
P
V
I
K
NLPPL
FK
S
F
PND
P
S
A
RRIG
G
YLMWM
MV
I
S
T
SL
S
S
S
MF
V
T
GA
APN
V
L
G
L
EF
V
SK
I
A
G
I
--
QISW
L
Q
WFL
CF
LP
V
G
V
ILL
I
I
A
PWL
S
YVLY
K
PEI
T
HS
E
E
V
A
TWA
GD
EL
KT
MG
A
L
TR
RE
W
T
L
I
GL
V
L
L
S
L
G
LW
V
FG
SEV
--
I
N
AT
A
VG
LL
A
V
S
LML
A
--
L
H
V
V
P
WKDI
T
R
YN
S
AWNTL
V
N
LA
T
L
V
V
M
A
N
GLT
RS
GFI
D
WFA
NTMST
HL
E
G
F
SP
NA
----
TVI
VL
V
L
VFY
FA
H
Y
L
FAS
L
SA
H
T
A
T
MLPV
IL
A
V
G
KGI
P
---
G
V
P
M
EQL
C
I
L
L
VL
SIG
I
M
G
C
LTPYATGPG
V
IIYG
C
GY
VKSK
DYWRLGAIFGVI
Y
ISM
LL
L
VG
WP
IL
A
M
W
N
fig|439855.10.peg.801
Escherichia coli SMS-3-5
M
APL
V
V
MG
VM
F
LIP
V
P
D
G
M
PPQ
AW
H
YFAVF
V
A
M
IVG
M
ILEP
I
P
AT
AI
SF
IAVTI
CV
I
G
S
NY
LLF
DAKE
LA
D
P
A
F
NAQ
K
QA
L
K
W
G
L
A
GFSS
T
T
V
WLVF
G
AF
I
F
AL
GYE
V
TGLGRRIAL
F
LVK
F
MG
K
RTL
T
LGYA
I
V
I
I
D
I
L
LAP
F
TPSNTAR
T
GG
T
V
F
P
V
I
K
NLPPL
FK
S
F
PND
P
S
A
RRIG
G
YLMWM
MV
I
S
T
SL
S
S
S
MF
V
T
GA
APN
V
L
G
L
EF
V
SK
I
A
G
I
--
QISW
L
Q
WFL
SF
LP
V
GIILL
I
V
A
PWL
S
YVLY
K
PE
V
T
HS
A
E
V
A
A
WA
GD
EL
KT
MG
A
L
SR
K
E
W
T
L
I
GL
V
L
L
S
L
G
LW
V
FG
GEM
--
IDAT
A
VG
LL
A
V
S
LML
A
--
L
H
V
V
P
WKDI
T
R
YN
S
AWNTL
V
N
LA
T
L
V
V
M
A
N
GLT
RS
GFI
D
WFA
STMST
HL
E
G
F
SP
NA
----
TVI
VL
V
L
VFY
FA
H
Y
L
FAS
L
SA
H
T
A
T
MLPV
IL
A
V
G
KGI
P
---
G
V
P
M
EQL
C
I
L
L
VL
SIG
I
M
G
C
LTPYATGPG
V
IIYG
C
GY
VKSK
DYWRLGAIFGVI
Y
ISM
LL
L
VG
WP
IL
A
M
W
N
fig|316385.5.peg.569
Escherichia coli str. K-12 substr. DH10B
M
PPQ
AW
H
YFAVF
V
A
M
IVG
M
ILEP
I
P
AT
AI
SF
IAVTI
CV
I
G
S
NY
LLF
DAKE
LA
D
P
A
F
NAQ
K
QA
L
K
W
G
L
A
GFSS
T
T
V
WLVF
G
AF
I
F
AL
GYE
V
S
GLGRRIAL
F
LVK
F
MG
K
RTL
T
LGYA
I
V
I
I
D
I
L
LAP
F
TPSNTAR
T
GG
T
V
F
P
V
I
K
NLPPL
FK
S
F
PND
P
S
A
RRIG
G
YLMWM
MV
I
S
T
SL
S
S
S
MF
V
T
GA
APN
V
L
G
L
EF
V
SK
I
A
G
I
--
QISW
L
Q
WFL
CF
LP
V
G
V
ILL
I
I
A
PWL
S
YVLY
K
PEI
T
HS
E
E
V
A
TWA
GD
EL
KT
MG
A
L
TR
RE
W
T
L
I
GL
V
L
L
S
L
G
LW
V
FG
SEV
--
I
N
AT
A
VG
LL
A
V
S
LML
A
--
L
H
V
V
P
WKDI
T
R
YN
S
AWNTL
V
N
LA
T
L
V
V
M
A
N
GLT
RS
GFI
D
WFA
GTMST
HL
E
G
F
SP
NA
----
TVI
VL
V
L
VFY
FA
H
Y
L
FAS
L
SA
H
T
A
T
MLPV
IL
A
V
G
KGI
P
---
G
V
P
M
EQL
C
I
L
L
VL
SIG
I
M
G
C
LTPYATGPG
V
IIYG
C
GY
VKSK
DYWRLGAIFGVI
Y
ISM
LL
L
VG
WP
IL
A
M
W
N
fig|316385.5.peg.680
Escherichia coli str. K-12 substr. DH10B
M
PPQ
AW
H
YFAVF
V
A
M
IVG
M
ILEP
I
P
AT
AI
SF
IAVTI
CV
I
G
S
NY
LLF
DAKE
LA
D
P
A
F
NAQ
K
QA
L
K
W
G
L
A
GFSS
T
T
V
WLVF
G
AF
I
F
AL
GYE
V
S
GLGRRIAL
F
LVK
F
MG
K
RTL
T
LGYA
I
V
I
I
D
I
L
LAP
F
TPSNTAR
T
GG
T
V
F
P
V
I
K
NLPPL
FK
S
F
PND
P
S
A
RRIG
G
YLMWM
MV
I
S
T
SL
S
S
S
MF
V
T
GA
APN
V
L
G
L
EF
V
SK
I
A
G
I
--
QISW
L
Q
WFL
CF
LP
V
G
V
ILL
I
I
A
PWL
S
YVLY
K
PEI
T
HS
E
E
V
A
TWA
GD
EL
KT
MG
A
L
TR
RE
W
T
L
I
GL
V
L
L
S
L
G
LW
V
FG
SEV
--
I
N
AT
A
VG
LL
A
V
S
LML
A
--
L
H
V
V
P
WKDI
T
R
YN
S
AWNTL
V
N
LA
T
L
V
V
M
A
N
GLT
RS
GFI
D
WFA
GTMST
HL
E
G
F
SP
NA
----
TVI
VL
V
L
VFY
FA
H
Y
L
FAS
L
SA
H
T
A
T
MLPV
IL
A
V
G
KGI
P
---
G
V
P
M
EQL
C
I
L
L
VL
SIG
I
M
G
C
LTPYATGPG
V
IIYG
C
GY
VKSK
DYWRLGAIFGVI
Y
ISM
LL
L
VG
WP
IL
A
M
W
N
fig|749545.3.peg.1826
Escherichia coli MS 182-1 (11-478/487)
LAPLAV
IA
II
A
LIP
V
PAGL
ESH
T
W
L
YFAVF
T
G
V
IVGLILEP
V
P
GA
VV
AM
VGI
S
I
IA
I
L
S
PW
LLF
SPEQ
LA
Q
P
G
F
KFT
A
KS
L
S
W
A
V
SGFS
N
S
V
I
WL
I
F
A
AF
M
F
GT
GYE
K
TGLGRRIAL
F
LVKKMG
H
RTL
F
LGYA
V
M
F
S
E
L
I
LAP
V
TPSN
S
AR
G
A
GI
I
Y
PII
R
NLPPL
YQ
S
Q
PNDSS
S
R
S
IG
S
Y
I
MWM
GI
V
A
D
CV
TS
A
I
F
L
TAMAPNLL
L
I
GL
M
KS
A
S
H
A
--
TL
SWG
D
WFL
GM
LP
L
S
I
L
L
M
L
L
V
PWL
A
YVLYPP
VL
K
SG
D
Q
V
P
R
WA
ET
EL
QA
MGPL
CS
REK
R
M
LGL
M
V
G
AL
V
LWIFG
GDY
--
IDA
A
M
VG
YS
VVALMLL
--
L
R
I
I
S
W
D
DIV
S
NK
A
AWN
VF
F
WLA
S
LI
T
LA
T
GL
N
NT
GFI
S
WF
G
KLLAG
S
L
S
G
Y
SP
TM
----
VMV
A
LI
V
VFY
LL
RYFFAS
A
T
AYT
S
A
LA
P
M
MI
A
A
A
LAM
P
---
E
I
PL
PVF
CL
M
V
GA
A
IG
L
G
S
I
LTPYATGP
S
PI
Y
YG
S
GY
LPTV
DYWRLGAIFG
L
I
-
FLVLL
V
I
T
G
fig|749532.3.peg.605
Escherichia coli MS 78-1 (11-478/487)
LAPLAV
IA
II
A
LIP
V
PAGL
ESH
T
W
L
YFAVF
T
G
V
IVGLILEP
V
P
GA
VV
AM
VGI
S
I
IA
I
L
S
PW
LLF
SPEQ
LA
Q
P
G
F
KFT
A
KS
L
S
W
A
V
SGFS
N
S
V
I
WL
I
F
A
AF
M
F
GT
GYE
K
TGLGRRIAL
F
LVKKMG
H
RTL
F
LGYA
V
M
F
S
E
L
I
LAP
V
TPSN
S
AR
G
A
GI
I
Y
PII
R
NLPPL
YQ
S
Q
PNDSS
S
R
S
IG
S
Y
I
MWM
GI
V
A
D
CV
TS
A
I
F
L
TAMAPNLL
L
I
GL
M
KS
A
S
H
A
--
TL
SWG
D
WFL
GM
LP
L
S
I
L
L
M
L
L
V
PWL
A
YVLYPP
VL
K
SG
D
Q
V
P
R
WA
ET
EL
QA
MGPL
CS
REK
R
M
LGL
M
V
G
AL
V
LWIFG
GDY
--
IDA
A
M
VG
YS
VVALMLL
--
L
R
I
I
S
W
D
DIV
S
NK
A
AWN
VF
F
WLA
S
LI
T
LA
T
GL
N
NT
GFI
S
WF
G
KLLAG
S
L
S
G
Y
SP
TM
----
VMV
A
LI
V
VFY
LL
RYFFAS
A
T
AYT
S
A
LA
P
M
MI
A
A
A
LAM
P
---
E
I
PL
PVF
CL
M
V
GA
A
IG
L
G
S
I
LTPYATGP
S
PI
Y
YG
S
GY
LPTV
DYWRLGAIFG
L
I
-
FLVLL
V
I
T
G
fig|656444.3.peg.4313
Escherichia coli TA280 (11-478/487)
LAPLAV
IA
II
A
LIP
V
PAGL
ESH
T
W
L
YFAVF
T
G
V
IVGLILEP
V
P
GA
VV
AM
VGI
S
I
IA
I
L
S
PW
LLF
SPEQ
LA
Q
P
G
F
KFT
A
KS
L
S
W
A
V
SGFS
N
S
V
I
WL
I
F
A
AF
M
F
GT
GYE
K
TGLGRRIAL
I
LVKKMG
H
RTL
F
LGYA
V
M
F
S
E
L
I
LAP
V
TPSN
S
AR
G
A
GI
I
Y
PII
R
NLPPL
YQ
S
Q
PNDSS
S
R
S
IG
S
Y
I
MWM
GI
V
A
D
CV
TS
A
I
F
L
TAMAPNLL
L
I
GL
M
KS
A
S
N
A
--
TL
SWG
D
WFL
GM
LP
L
S
I
L
L
V
L
L
V
PWL
A
YVLYPP
VL
K
SG
D
Q
V
P
R
WA
ET
EL
QA
MGPL
CS
REK
R
M
LGL
M
V
G
AL
V
LWIFG
GDY
--
IDA
A
M
VG
YS
VVALMLL
--
L
R
I
I
C
W
D
DIV
S
NK
A
AWN
VF
F
WLA
S
LI
T
LA
T
GL
N
NT
GFI
S
WF
G
KLLAG
S
L
S
G
Y
SP
TM
----
VIV
A
LI
V
VFY
LL
RYFFAS
A
T
AYT
S
A
LA
P
M
MI
A
A
A
LAM
P
---
E
I
PL
PVF
CL
M
V
GA
A
IG
L
G
S
I
LTPYATGP
S
PI
Y
YG
S
GY
LPTE
DYWRLGAIFG
L
I
-
FLVLL
V
I
T
G
fig|679207.4.peg.3778
Escherichia coli MS 107-1 (11-478/487)
LAPLAV
IA
II
A
LIP
V
PAGL
ESH
T
W
L
YFAVF
T
G
V
IVGLILEP
V
P
GA
VV
AM
VGI
S
I
IA
I
L
S
PW
LLF
SPEQ
LA
Q
P
G
F
KFT
A
KS
L
S
W
A
V
SGFS
N
S
V
I
WL
I
F
A
AF
M
F
GT
GYE
K
TGLGRRIAL
F
LVKKMG
H
RTL
F
LGYA
V
M
F
S
E
L
I
LAP
V
TPSN
S
AR
G
A
GI
I
Y
PII
R
NLPPL
YQ
S
Q
PNDSS
S
R
S
IG
S
Y
I
MWM
GI
V
A
D
CV
TS
A
I
F
L
TAMAPNLL
L
I
GL
M
KS
A
S
H
A
--
TL
SWG
D
WFL
GM
LP
L
S
I
L
L
V
L
L
V
PWL
A
YVLYPP
VL
K
SG
D
Q
V
P
R
WA
ET
EL
QA
MGPL
CS
REK
R
M
LGL
M
V
G
AL
V
LWIFG
GDY
--
IDA
A
M
VG
YS
VVALMLL
--
L
R
I
I
S
W
D
DIV
S
NK
A
AWN
VF
F
WLA
S
LI
T
LA
T
GL
N
NT
GFI
S
WF
G
KLLAG
S
L
S
G
Y
SP
TM
----
VMV
A
LI
V
VFY
LL
RYFFAS
A
T
AYT
S
A
LA
P
M
MI
A
A
A
LAM
P
---
E
I
PL
PVF
CL
M
V
GA
A
IG
L
G
S
I
LTPYATGP
S
PI
Y
YG
S
GY
LPTA
DYWRLGAIFG
L
I
-
FLVLL
V
I
T
G
fig|6666666.5357.peg.4444
Escherichia coli TY-2482 (11-478/487)
LAPLAV
IA
II
A
LIP
V
PAGL
ESH
T
W
L
YFAVF
T
G
V
IVGLILEP
V
P
GA
VV
AM
VGI
S
I
IA
I
L
S
PW
LLF
SPEQ
LA
Q
P
G
F
KFT
A
KS
L
S
W
A
V
SGFS
N
S
V
I
WL
I
F
A
AF
M
F
GT
GYE
K
TGLGRRIAL
F
LVKKMG
H
RTL
F
LGYA
V
M
F
S
E
L
I
LAP
V
TPSN
S
AR
G
A
GI
I
Y
PII
R
NLPPL
YQ
S
Q
PNDSS
S
R
S
IG
S
Y
I
MWM
GI
V
A
D
CV
TS
A
I
F
L
TAMAPNLL
L
I
GL
M
KS
A
S
H
A
--
TL
SWG
D
WFL
GM
LP
L
S
I
L
L
V
L
L
V
PWL
A
YVLYPP
VL
K
SG
D
Q
V
P
R
WA
ET
EL
QA
MGPL
CS
REK
R
M
LGL
M
V
G
AL
V
LWIFG
GDY
--
IDA
A
M
VG
YS
VVALMLL
--
L
R
I
I
S
W
D
DIV
S
NK
A
AWN
VF
F
WLA
S
LI
T
LA
T
GL
N
NT
GFI
S
WF
G
KLLAG
S
L
S
G
Y
SP
TM
----
VMV
A
LI
V
VFY
LL
RYFFAS
A
T
AYT
S
A
LA
P
M
MI
A
A
A
LAM
P
---
E
I
PL
PVF
CL
M
V
GA
A
IG
L
G
S
I
LTPYATGP
S
PI
Y
YG
S
GY
LPTV
DYWRLGAIFG
L
I
-
FLVLL
V
I
T
G
fig|585055.6.peg.3512
Escherichia coli 55989 (11-478/487)
LAPLAV
IA
II
A
LIP
V
PAGL
ESH
T
W
L
YFAVF
T
G
V
IVGLILEP
V
P
GA
VV
AM
VGI
S
I
IA
I
L
S
PW
LLF
SPEQ
LA
Q
P
G
F
KFT
A
KS
L
S
W
A
V
SGFS
N
S
V
I
WL
I
F
A
AF
M
F
GT
GYE
K
TGLGRRIAL
F
LVKKMG
H
RTL
F
LGYA
V
M
F
S
E
L
I
LAP
V
TPSN
S
AR
G
A
GI
I
Y
PII
R
NLPPL
YQ
S
Q
PNDSS
S
R
S
IG
S
Y
I
MWM
GI
V
A
D
CV
TS
A
I
F
L
TAMAPNLL
L
I
GL
M
KS
A
S
H
A
--
TL
SWG
D
WFL
GM
LP
L
S
I
L
L
V
L
L
V
PWL
A
YVLYPP
VL
K
SG
D
Q
V
P
R
WA
ET
EL
QA
MGPL
CS
REK
R
M
LGL
M
V
G
AL
V
LWIFG
GDY
--
IDA
A
M
VG
YS
VVALMLL
--
L
R
I
I
S
W
D
DIV
S
NK
A
AWN
VF
F
WLA
S
LI
T
LA
T
GL
N
NT
GFI
S
WF
G
KLLAG
S
L
S
G
Y
SP
TM
----
VMV
A
LI
V
VFY
LL
RYFFAS
A
T
AYT
S
A
LA
P
M
MI
A
A
A
LAM
P
---
E
I
PL
PVF
CL
M
V
GA
A
IG
L
G
S
I
LTPYATGP
S
PI
Y
YG
S
GY
LPTV
DYWRLGAIFG
L
I
-
FLVLL
V
I
T
G
fig|585055.8.peg.3515
Escherichia coli 55989 (11-478/487)
LAPLAV
IA
II
A
LIP
V
PAGL
ESH
T
W
L
YFAVF
T
G
V
IVGLILEP
V
P
GA
VV
AM
VGI
S
I
IA
I
L
S
PW
LLF
SPEQ
LA
Q
P
G
F
KFT
A
KS
L
S
W
A
V
SGFS
N
S
V
I
WL
I
F
A
AF
M
F
GT
GYE
K
TGLGRRIAL
F
LVKKMG
H
RTL
F
LGYA
V
M
F
S
E
L
I
LAP
V
TPSN
S
AR
G
A
GI
I
Y
PII
R
NLPPL
YQ
S
Q
PNDSS
S
R
S
IG
S
Y
I
MWM
GI
V
A
D
CV
TS
A
I
F
L
TAMAPNLL
L
I
GL
M
KS
A
S
H
A
--
TL
SWG
D
WFL
GM
LP
L
S
I
L
L
V
L
L
V
PWL
A
YVLYPP
VL
K
SG
D
Q
V
P
R
WA
ET
EL
QA
MGPL
CS
REK
R
M
LGL
M
V
G
AL
V
LWIFG
GDY
--
IDA
A
M
VG
YS
VVALMLL
--
L
R
I
I
S
W
D
DIV
S
NK
A
AWN
VF
F
WLA
S
LI
T
LA
T
GL
N
NT
GFI
S
WF
G
KLLAG
S
L
S
G
Y
SP
TM
----
VMV
A
LI
V
VFY
LL
RYFFAS
A
T
AYT
S
A
LA
P
M
MI
A
A
A
LAM
P
---
E
I
PL
PVF
CL
M
V
GA
A
IG
L
G
S
I
LTPYATGP
S
PI
Y
YG
S
GY
LPTV
DYWRLGAIFG
L
I
-
FLVLL
V
I
T
G
fig|550672.3.peg.3306
Escherichia coli B088 (11-478/487)
LAPLAV
IA
II
A
L
L
P
V
PAGL
ENH
T
W
L
YFAVF
T
G
V
IVGLILEP
V
P
GA
VV
AM
VGI
S
I
IA
I
L
S
PW
LLF
SPEQ
LA
Q
P
G
F
KFT
A
KS
L
S
W
A
V
SGFS
N
S
V
I
WL
I
F
A
AF
M
F
GT
GYE
K
TGLGRRIAL
F
LVKKMG
H
RTL
F
LGYA
V
M
F
S
E
L
I
LAP
V
TPSN
S
AR
G
A
GI
I
Y
PII
R
NLPPL
YQ
S
Q
PNDSS
S
R
S
IG
S
Y
I
MWM
GI
V
A
D
CV
TS
A
I
F
L
TAMAPNLL
L
I
GL
M
KS
A
S
H
A
--
TL
SWG
D
WFL
GM
LP
L
S
I
L
L
V
L
L
V
PWL
A
YVLYPP
VL
K
SG
D
Q
V
P
R
WA
ET
EL
QA
MGPL
CS
REK
R
M
LGL
M
V
G
AL
V
LWIFG
GDY
--
IDA
A
M
VG
YS
VVALMLL
--
L
R
I
I
S
W
D
DIV
S
NK
A
AWN
VF
F
WLA
S
LI
T
LA
T
GL
N
NT
GFI
S
WF
G
KLLAG
S
L
S
G
Y
SP
TM
----
VMV
A
LI
V
VFY
LL
RYFFAS
A
T
AYT
S
A
LA
P
M
MI
A
A
A
LAM
P
---
E
I
PL
PVF
CL
M
V
GA
A
IG
L
G
S
I
LTPYATGP
S
PI
Y
YG
S
GY
LPTV
DYWRLGAIFG
L
I
-
FLVLL
V
I
T
G
fig|340186.3.peg.475
Escherichia coli E110019 (11-478/487)
LAPLAV
IA
II
A
L
L
P
V
PAGL
ENH
T
W
L
YFAVF
T
G
V
IVGLILEP
V
P
GA
VV
AM
VGI
S
I
IA
I
L
S
PW
LLF
SPEQ
LA
Q
P
G
F
KFT
A
KS
L
S
W
A
V
SGFS
N
S
V
I
WL
I
F
A
AF
M
F
GT
GYE
K
TGLGRRIAL
F
LVKKMG
H
RTL
F
LGYA
V
M
F
S
E
L
I
LAP
V
TPSN
S
AR
G
A
GI
I
Y
PII
R
NLPPL
YQ
S
Q
PNDSS
S
R
S
IG
S
Y
I
MWM
GI
V
A
D
CV
TS
A
I
F
L
TAMAPNLL
L
I
GL
M
KS
A
S
H
A
--
TL
SWG
D
WFL
GM
LP
L
S
I
L
L
V
L
L
V
PWL
A
YVLYPP
VL
K
SG
D
Q
V
P
R
WA
ET
EL
QA
MGPL
CS
REK
R
M
LGL
M
V
G
AL
V
LWIFG
GDY
--
IDA
A
M
VG
YS
VVALMLL
--
L
R
I
I
S
W
D
DIV
S
NK
A
AWN
VF
F
WLA
S
LI
T
LA
T
GL
N
NT
GFI
S
WF
G
KLLAG
S
L
S
G
Y
SP
TM
----
VMV
A
LI
V
VFY
LL
RYFFAS
A
T
AYT
S
A
LA
P
M
MI
A
A
A
LAM
P
---
E
I
PL
PVF
CL
M
V
GA
A
IG
L
G
S
I
LTPYATGP
S
PI
Y
YG
S
GY
LPTV
DYWRLGAIFG
L
I
-
FLVLL
V
I
T
G
fig|340186.5.peg.496
Escherichia coli E110019 (11-478/487)
LAPLAV
IA
II
A
L
L
P
V
PAGL
ENH
T
W
L
YFAVF
T
G
V
IVGLILEP
V
P
GA
VV
AM
VGI
S
I
IA
I
L
S
PW
LLF
SPEQ
LA
Q
P
G
F
KFT
A
KS
L
S
W
A
V
SGFS
N
S
V
I
WL
I
F
A
AF
M
F
GT
GYE
K
TGLGRRIAL
F
LVKKMG
H
RTL
F
LGYA
V
M
F
S
E
L
I
LAP
V
TPSN
S
AR
G
A
GI
I
Y
PII
R
NLPPL
YQ
S
Q
PNDSS
S
R
S
IG
S
Y
I
MWM
GI
V
A
D
CV
TS
A
I
F
L
TAMAPNLL
L
I
GL
M
KS
A
S
H
A
--
TL
SWG
D
WFL
GM
LP
L
S
I
L
L
V
L
L
V
PWL
A
YVLYPP
VL
K
SG
D
Q
V
P
R
WA
ET
EL
QA
MGPL
CS
REK
R
M
LGL
M
V
G
AL
V
LWIFG
GDY
--
IDA
A
M
VG
YS
VVALMLL
--
L
R
I
I
S
W
D
DIV
S
NK
A
AWN
VF
F
WLA
S
LI
T
LA
T
GL
N
NT
GFI
S
WF
G
KLLAG
S
L
S
G
Y
SP
TM
----
VMV
A
LI
V
VFY
LL
RYFFAS
A
T
AYT
S
A
LA
P
M
MI
A
A
A
LAM
P
---
E
I
PL
PVF
CL
M
V
GA
A
IG
L
G
S
I
LTPYATGP
S
PI
Y
YG
S
GY
LPTV
DYWRLGAIFG
L
I
-
FLVLL
V
I
T
G
fig|656408.3.peg.3474
Escherichia coli H591 (11-478/487)
LAPLAV
IA
II
A
L
L
P
V
PAGL
ENH
T
W
L
YFAVF
T
G
V
IVGLILEP
V
P
GA
VV
AM
VGI
S
I
IA
I
L
S
PW
LLF
SPEQ
LA
Q
P
G
F
KFT
A
KS
L
S
W
A
V
SGFS
N
S
V
I
WL
I
F
A
AF
M
F
GT
GYE
K
TGLGRRIAL
F
LVKKMG
H
RTL
F
LGYA
V
M
F
S
E
L
I
LAP
V
TPSN
S
AR
G
A
GI
I
Y
PII
R
NLPPL
YQ
S
Q
PNDSS
S
R
S
IG
S
Y
I
MWM
GI
V
A
D
CV
TS
A
I
F
L
TAMAPNLL
L
I
GL
M
KS
A
S
H
A
--
TL
SWG
D
WFL
GM
LP
L
S
I
L
L
V
L
L
V
PWL
A
YVLYPP
VL
K
SG
D
Q
V
P
R
WA
ET
EL
QA
MGPL
CS
REK
R
M
LGL
M
V
G
AL
V
LWIFG
GDY
--
IDA
A
M
VG
YS
VVALMLL
--
L
R
I
I
S
W
D
DIV
S
NK
A
AWN
VF
F
WLA
S
LI
T
LA
T
GL
N
NT
GFI
S
WF
G
KLLAG
S
L
S
G
Y
SP
TM
----
VMV
A
LI
V
VFY
LL
RYFFAS
A
T
AYT
S
A
LA
P
M
MI
A
A
A
LAM
P
---
E
I
PL
PVF
CL
M
V
GA
A
IG
L
G
S
I
LTPYATGP
S
PI
Y
YG
S
GY
LPTV
DYWRLGAIFG
L
I
-
FLVLL
V
I
T
G
fig|679206.4.peg.1428
Escherichia coli MS 119-7 (11-478/487)
LAPLAV
IA
II
A
L
L
P
V
PAGL
ENH
T
W
L
YFAVF
T
G
V
IVGLILEP
V
P
GA
VV
AM
VGI
S
I
IA
I
L
S
PW
LLF
SPEQ
LA
Q
P
G
F
KFT
A
KS
L
S
W
A
V
SGFS
N
S
V
I
WL
I
F
A
AF
M
F
GT
GYE
K
TGLGRRIAL
F
LVKKMG
H
RTL
F
LGYA
V
M
F
S
E
L
I
LAP
V
TPSN
S
AR
G
A
GI
I
Y
PII
R
NLPPL
YQ
S
Q
PNDSS
S
R
S
IG
S
Y
I
MWM
GI
V
A
D
CV
TS
A
I
F
L
TAMAPNLL
L
I
GL
M
KS
A
S
H
A
--
TL
SWG
D
WFL
GM
LP
L
S
I
L
L
V
L
L
V
PWL
A
YVLYPP
VL
K
SG
D
Q
V
P
R
WA
ET
EL
QA
MGPL
CS
REK
R
M
LGL
M
V
G
AL
V
LWIFG
GDY
--
IDA
A
M
VG
YS
VVALMLL
--
L
R
I
I
S
W
D
DIV
S
NK
A
AWN
VF
F
WLA
S
LI
T
LA
T
GL
N
NT
GFI
S
WF
G
KLLAG
S
L
S
G
Y
SP
TM
----
VMV
A
LI
V
VFY
LL
RYFFAS
A
T
AYT
S
A
LA
P
M
MI
A
A
A
LAM
P
---
E
I
PL
PVF
CL
M
V
GA
A
IG
L
G
S
I
LTPYATGP
S
PI
Y
YG
S
GY
LPTV
DYWRLGAIFG
L
I
-
FLVLL
V
I
T
G
fig|585396.4.peg.4022
Escherichia coli O111:H- str. 11128 (11-478/487)
LAPLAV
IA
II
A
L
L
P
V
PAGL
ENH
T
W
L
YFAVF
T
G
V
IVGLILEP
V
P
GA
VV
AM
VGI
S
I
IA
I
L
S
PW
LLF
SPEQ
LA
Q
P
G
F
KFT
A
KS
L
S
W
A
V
SGFS
N
S
V
I
WL
I
F
A
AF
M
F
GT
GYE
K
TGLGRRIAL
F
LVKKMG
H
RTL
F
LGYA
V
M
F
S
E
L
I
LAP
V
TPSN
S
AR
G
A
GI
I
Y
PII
R
NLPPL
YQ
S
Q
PNDSS
S
R
S
IG
S
Y
I
MWM
GI
V
A
D
CV
TS
A
I
F
L
TAMAPNLL
L
I
GL
M
KS
A
S
H
A
--
TL
SWG
D
WFL
GM
LP
L
S
I
L
L
V
L
L
V
PWL
A
YVLYPP
VL
K
SG
D
Q
V
P
R
WA
ET
EL
QA
MGPL
CS
REK
R
M
LGL
M
V
G
AL
V
LWIFG
GDY
--
IDA
A
M
VG
YS
VVALMLL
--
L
R
I
I
S
W
D
DIV
S
NK
A
AWN
VF
F
WLA
S
LI
T
LA
T
GL
N
NT
GFI
S
WF
G
KLLAG
S
L
S
G
Y
SP
TM
----
VMV
A
LI
V
VFY
LL
RYFFAS
A
T
AYT
S
A
LA
P
M
MI
A
A
A
LAM
P
---
E
I
PL
PVF
CL
M
V
GA
A
IG
L
G
S
I
LTPYATGP
S
PI
Y
YG
S
GY
LPTV
DYWRLGAIFG
L
I
-
FLVLL
V
I
T
G
fig|573235.3.peg.4263
Escherichia coli O26:H11 str. 11368 (11-478/487)
LAPLAV
IA
II
A
L
L
P
V
PAGL
ENH
T
W
L
YFAVF
T
G
V
IVGLILEP
V
P
GA
VV
AM
VGI
S
I
IA
I
L
S
PW
LLF
SPEQ
LA
Q
P
G
F
KFT
A
KS
L
S
W
A
V
SGFS
N
S
V
I
WL
I
F
A
AF
M
F
GT
GYE
K
TGLGRRIAL
F
LVKKMG
H
RTL
F
LGYA
V
M
F
S
E
L
I
LAP
V
TPSN
S
AR
G
A
GI
I
Y
PII
R
NLPPL
YQ
S
Q
PNDSS
S
R
S
IG
S
Y
I
MWM
GI
V
A
D
CV
TS
A
I
F
L
TAMAPNLL
L
I
GL
M
KS
A
S
H
A
--
TL
SWG
D
WFL
GM
LP
L
S
I
L
L
V
L
L
V
PWL
A
YVLYPP
VL
K
SG
D
Q
V
P
R
WA
ET
EL
QA
MGPL
CS
REK
R
M
LGL
M
V
G
AL
V
LWIFG
GDY
--
IDA
A
M
VG
YS
VVALMLL
--
L
R
I
I
S
W
D
DIV
S
NK
A
AWN
VF
F
WLA
S
LI
T
LA
T
GL
N
NT
GFI
S
WF
G
KLLAG
S
L
S
G
Y
SP
TM
----
VMV
A
LI
V
VFY
LL
RYFFAS
A
T
AYT
S
A
LA
P
M
MI
A
A
A
LAM
P
---
E
I
PL
PVF
CL
M
V
GA
A
IG
L
G
S
I
LTPYATGP
S
PI
Y
YG
S
GY
LPTV
DYWRLGAIFG
L
I
-
FLVLL
V
I
T
G
fig|656443.3.peg.3972
Escherichia coli TA271 (11-478/487)
LAPLAV
IA
II
A
L
L
P
V
PAGL
ENH
T
W
L
YFAVF
T
G
V
IVGLILEP
V
P
GA
VV
AM
VGI
S
I
IA
I
L
S
PW
LLF
SPEQ
LA
Q
P
G
F
KFT
A
KS
L
S
W
A
V
SGFS
N
S
V
I
WL
I
F
A
AF
M
F
GT
GYE
K
TGLGRRIAL
F
LVKKMG
H
RTL
F
LGYA
V
M
F
S
E
L
I
LAP
V
TPSN
S
AR
G
A
GI
I
Y
PII
R
NLPPL
YQ
S
Q
PNDSS
S
R
S
IG
S
Y
I
MWM
GI
V
A
D
CV
TS
A
I
F
L
TAMAPNLL
L
I
GL
M
KS
A
S
H
A
--
TL
SWG
D
WFL
GM
LP
L
S
I
L
L
V
L
L
V
PWL
A
YVLYPP
VL
K
SG
D
Q
V
P
R
WA
ET
EL
QA
MGPL
CS
REK
R
M
LGL
M
V
G
AL
V
LWIFG
GDY
--
IDA
A
M
VG
YS
VVALMLL
--
L
R
I
I
S
W
D
DIV
S
NK
A
AWN
VF
F
WLA
S
LI
T
LA
T
GL
N
NT
GFI
S
WF
G
KLLAG
S
L
S
G
Y
SP
TM
----
VMV
A
LI
V
VFY
LL
RYFFAS
A
T
AYT
S
A
LA
P
M
MI
A
A
A
LAM
P
---
E
I
PL
PVF
CL
M
V
GA
A
IG
L
G
S
I
LTPYATGP
S
PI
Y
YG
S
GY
LPTV
DYWRLGAIFG
L
I
-
FLVLL
V
I
T
G
fig|216592.1.peg.3983
Escherichia coli 042 (11-478/487)
LAPLAV
IA
II
A
LIP
V
PAGL
ESH
T
W
L
YFAVF
T
G
V
IVGLILEP
V
P
GA
VV
AM
VGI
S
I
IA
I
L
S
PW
LLF
SPEQ
LA
Q
P
G
F
KFT
A
KS
L
S
W
A
V
SGFS
N
S
V
I
WL
I
F
A
AF
M
F
GT
GYE
K
TGLGRRIAL
I
LVKKMG
H
RTL
F
LGYA
V
M
F
S
E
L
I
LAP
V
TPSN
S
AR
G
A
GI
I
Y
PII
R
NLPPL
YQ
S
Q
PNDSS
S
R
S
IG
S
Y
I
MWM
GI
V
A
D
CV
TS
A
I
F
L
TAMAPNLL
L
I
GL
M
KS
A
S
H
A
--
TL
SWG
D
WFL
GM
LP
L
S
I
L
L
V
L
L
V
PWL
A
YVLYPP
VL
K
SG
D
Q
V
P
R
WA
ET
EL
QA
MGPL
CS
REK
R
M
LGL
M
V
G
AL
V
LWIFG
GDY
--
IDA
A
M
VG
YS
VVALMLL
--
L
R
I
I
C
W
D
DIV
S
NK
A
AWN
VF
F
WLA
S
LI
T
LA
T
GL
N
NT
GFI
S
WF
G
KLLAG
S
L
N
G
Y
SP
TM
----
VMV
A
LI
V
VFY
LL
RYFFAS
A
T
AYT
S
A
LA
P
M
MI
A
A
A
LAM
P
---
E
I
PL
PVF
CL
M
V
GA
A
IG
L
G
S
I
LTPYATGP
S
PI
Y
YG
S
GY
LPTV
DYWRLGAIFG
L
I
-
FLVLL
V
I
T
G
fig|216592.3.peg.3488
Escherichia coli 042 (11-478/487)
LAPLAV
IA
II
A
LIP
V
PAGL
ESH
T
W
L
YFAVF
T
G
V
IVGLILEP
V
P
GA
VV
AM
VGI
S
I
IA
I
L
S
PW
LLF
SPEQ
LA
Q
P
G
F
KFT
A
KS
L
S
W
A
V
SGFS
N
S
V
I
WL
I
F
A
AF
M
F
GT
GYE
K
TGLGRRIAL
I
LVKKMG
H
RTL
F
LGYA
V
M
F
S
E
L
I
LAP
V
TPSN
S
AR
G
A
GI
I
Y
PII
R
NLPPL
YQ
S
Q
PNDSS
S
R
S
IG
S
Y
I
MWM
GI
V
A
D
CV
TS
A
I
F
L
TAMAPNLL
L
I
GL
M
KS
A
S
H
A
--
TL
SWG
D
WFL
GM
LP
L
S
I
L
L
V
L
L
V
PWL
A
YVLYPP
VL
K
SG
D
Q
V
P
R
WA
ET
EL
QA
MGPL
CS
REK
R
M
LGL
M
V
G
AL
V
LWIFG
GDY
--
IDA
A
M
VG
YS
VVALMLL
--
L
R
I
I
C
W
D
DIV
S
NK
A
AWN
VF
F
WLA
S
LI
T
LA
T
GL
N
NT
GFI
S
WF
G
KLLAG
S
L
N
G
Y
SP
TM
----
VMV
A
LI
V
VFY
LL
RYFFAS
A
T
AYT
S
A
LA
P
M
MI
A
A
A
LAM
P
---
E
I
PL
PVF
CL
M
V
GA
A
IG
L
G
S
I
LTPYATGP
S
PI
Y
YG
S
GY
LPTV
DYWRLGAIFG
L
I
-
FLVLL
V
I
T
G
fig|749531.3.peg.2435
Escherichia coli MS 69-1 (11-478/487)
LAPLAV
IA
II
A
LIP
V
PAGL
ESH
T
W
L
YFAVF
T
G
V
IVGLILEP
V
P
GA
VV
AM
VGI
S
I
IA
I
L
S
PW
LLF
SPEQ
LA
Q
P
G
F
KFT
A
KS
L
S
W
A
V
SGFS
N
S
V
I
WL
I
F
A
AF
M
F
GT
GYE
K
TGLGRRIAL
I
LVKKMG
H
RTL
F
LGYA
V
M
F
S
E
L
I
LAP
V
TPSN
S
AR
G
A
GI
I
Y
PII
R
NLPPL
YQ
S
Q
PNDSS
S
R
S
IG
S
Y
I
MWM
GI
V
A
D
CV
TS
A
I
F
L
TAMAPNLL
L
I
GL
M
KS
A
S
H
A
--
TL
SWG
D
WFL
GM
LP
L
S
I
L
L
V
L
L
V
PWL
A
YVLYPP
VL
K
SG
D
Q
V
P
R
WA
ET
EL
QA
MGPL
CS
REK
R
M
LGL
M
V
G
AL
V
LWIFG
GDY
--
IDA
A
M
VG
YS
VVALMLL
--
L
R
I
I
C
W
D
DIV
S
NK
A
AWN
VF
F
WLA
S
LI
T
LA
T
GL
N
NT
GFI
S
WF
G
KLLAG
S
L
N
G
Y
SP
TM
----
VMV
A
LI
V
VFY
LL
RYFFAS
A
T
AYT
S
A
LA
P
M
MI
A
A
A
LAM
P
---
E
I
PL
PVF
CL
M
V
GA
A
IG
L
G
S
I
LTPYATGP
S
PI
Y
YG
S
GY
LPTV
DYWRLGAIFG
L
I
-
FLVLL
V
I
T
G
fig|656437.3.peg.3480
Escherichia coli TA143 (11-478/487)
LAPLAV
IA
II
A
LIP
V
PAGL
ESH
T
W
L
YFAVF
T
G
V
IVGLILEP
V
P
GA
VV
AM
VGI
S
I
IA
I
L
S
PW
LLF
SPEQ
LA
Q
P
G
F
KFT
A
KS
L
S
W
A
V
SGFS
N
S
V
I
WL
I
F
A
AF
M
F
GT
GYE
K
TGLGRRIAL
I
LVKKMG
H
RTL
F
LGYA
V
M
F
S
E
L
I
LAP
V
TPSN
S
AR
G
A
GI
I
Y
PII
R
NLPPL
YQ
S
Q
PNDSS
S
R
S
IG
S
Y
I
MWM
GI
V
A
D
CV
TS
A
I
F
L
TAMAPNLL
L
I
GL
M
KS
A
S
H
A
--
TL
SWG
D
WFL
GM
LP
L
S
I
L
L
V
L
L
V
PWL
A
YVLYPP
VL
K
SG
D
Q
V
P
R
WA
ET
EL
QA
MGPL
CS
REK
R
M
LGL
M
V
G
AL
V
LWIFG
GDY
--
IDA
A
M
VG
YS
VVALMLL
--
L
R
I
I
C
W
D
DIV
S
NK
A
AWN
VF
F
WLA
S
LI
T
LA
T
GL
N
NT
GFI
S
WF
G
KLLAG
S
L
N
G
Y
SP
TM
----
VMV
A
LI
V
VFY
LL
RYFFAS
A
T
AYT
S
A
LA
P
M
MI
A
A
A
LAM
P
---
E
I
PL
PVF
CL
M
V
GA
A
IG
L
G
S
I
LTPYATGP
S
PI
Y
YG
S
GY
LPTV
DYWRLGAIFG
L
I
-
FLVLL
V
I
T
G
fig|562.371.peg.2364
Escherichia coli 1044A (11-478/487)
LAPLAV
IA
II
A
LIP
V
PAGL
ESH
T
W
L
YFAVF
T
G
V
IVGLILEP
V
P
GA
VV
AM
VGI
S
I
IA
I
L
S
PW
LLF
SPEQ
LA
Q
P
G
F
KFT
A
KS
L
S
W
A
V
SGFS
N
S
V
I
WL
I
F
A
AF
M
F
GT
GYE
K
TGLGRRIAL
I
LVKKMG
H
RTL
F
LGYA
V
M
F
S
E
L
I
LAP
V
TPSN
S
AR
G
A
GI
I
Y
PII
R
NLPPL
YQ
S
Q
PNDSS
S
R
S
IG
S
Y
I
MWM
GI
V
A
D
CV
TS
A
I
F
L
TAMAPNLL
L
I
GL
M
KS
A
S
H
A
--
TL
SWG
D
WFL
GM
LP
L
S
I
L
L
V
L
L
V
PWL
A
YVLYPP
VL
K
SG
D
Q
V
P
R
WA
ET
EL
QA
MGPL
CS
REK
R
M
LGL
M
V
G
AL
V
LWIFG
GDY
--
IDA
A
M
VG
YS
VVALMLL
--
L
R
I
I
S
W
D
DIV
S
NK
A
AWN
VF
F
WLA
S
LI
T
LA
T
GL
N
NT
GFI
S
WF
G
KLLAG
S
L
S
G
Y
SP
TM
----
VMV
A
LI
V
VFY
LL
RYFFAS
A
T
AYT
S
A
LA
P
M
MI
A
A
A
LAM
P
---
E
I
PL
PVF
CL
M
V
GA
A
IG
L
G
S
I
LTPYATGP
S
PI
Y
YG
S
GY
LPTA
DYWRLGAIFG
L
I
-
FLVLL
V
I
T
G
fig|562.373.peg.1840
Escherichia coli 1125A (11-478/487)
LAPLAV
IA
II
A
LIP
V
PAGL
ESH
T
W
L
YFAVF
T
G
V
IVGLILEP
V
P
GA
VV
AM
VGI
S
I
IA
I
L
S
PW
LLF
SPEQ
LA
Q
P
G
F
KFT
A
KS
L
S
W
A
V
SGFS
N
S
V
I
WL
I
F
A
AF
M
F
GT
GYE
K
TGLGRRIAL
I
LVKKMG
H
RTL
F
LGYA
V
M
F
S
E
L
I
LAP
V
TPSN
S
AR
G
A
GI
I
Y
PII
R
NLPPL
YQ
S
Q
PNDSS
S
R
S
IG
S
Y
I
MWM
GI
V
A
D
CV
TS
A
I
F
L
TAMAPNLL
L
I
GL
M
KS
A
S
H
A
--
TL
SWG
D
WFL
GM
LP
L
S
I
L
L
V
L
L
V
PWL
A
YVLYPP
VL
K
SG
D
Q
V
P
R
WA
ET
EL
QA
MGPL
CS
REK
R
M
LGL
M
V
G
AL
V
LWIFG
GDY
--
IDA
A
M
VG
YS
VVALMLL
--
L
R
I
I
S
W
D
DIV
S
NK
A
AWN
VF
F
WLA
S
LI
T
LA
T
GL
N
NT
GFI
S
WF
G
KLLAG
S
L
S
G
Y
SP
TM
----
VMV
A
LI
V
VFY
LL
RYFFAS
A
T
AYT
S
A
LA
P
M
MI
A
A
A
LAM
P
---
E
I
PL
PVF
CL
M
V
GA
A
IG
L
G
S
I
LTPYATGP
S
PI
Y
YG
S
GY
LPTA
DYWRLGAIFG
L
I
-
FLVLL
V
I
T
G
fig|562.372.peg.2560
Escherichia coli 1212A (11-478/487)
LAPLAV
IA
II
A
LIP
V
PAGL
ESH
T
W
L
YFAVF
T
G
V
IVGLILEP
V
P
GA
VV
AM
VGI
S
I
IA
I
L
S
PW
LLF
SPEQ
LA
Q
P
G
F
KFT
A
KS
L
S
W
A
V
SGFS
N
S
V
I
WL
I
F
A
AF
M
F
GT
GYE
K
TGLGRRIAL
I
LVKKMG
H
RTL
F
LGYA
V
M
F
S
E
L
I
LAP
V
TPSN
S
AR
G
A
GI
I
Y
PII
R
NLPPL
YQ
S
Q
PNDSS
S
R
S
IG
S
Y
I
MWM
GI
V
A
D
CV
TS
A
I
F
L
TAMAPNLL
L
I
GL
M
KS
A
S
H
A
--
TL
SWG
D
WFL
GM
LP
L
S
I
L
L
V
L
L
V
PWL
A
YVLYPP
VL
K
SG
D
Q
V
P
R
WA
ET
EL
QA
MGPL
CS
REK
R
M
LGL
M
V
G
AL
V
LWIFG
GDY
--
IDA
A
M
VG
YS
VVALMLL
--
L
R
I
I
S
W
D
DIV
S
NK
A
AWN
VF
F
WLA
S
LI
T
LA
T
GL
N
NT
GFI
S
WF
G
KLLAG
S
L
S
G
Y
SP
TM
----
VMV
A
LI
V
VFY
LL
RYFFAS
A
T
AYT
S
A
LA
P
M
MI
A
A
A
LAM
P
---
E
I
PL
PVF
CL
M
V
GA
A
IG
L
G
S
I
LTPYATGP
S
PI
Y
YG
S
GY
LPTA
DYWRLGAIFG
L
I
-
FLVLL
V
I
T
G
fig|344610.3.peg.4716
Escherichia coli 53638 (11-478/487)
LAPLAV
IA
II
A
LIP
V
PAGL
ESH
T
W
L
YFAVF
T
G
V
IVGLILEP
V
P
GA
VV
AM
VGI
S
I
IA
I
L
S
PW
LLF
SPEQ
LA
Q
P
G
F
KFT
A
KS
L
S
W
A
V
SGFS
N
S
V
I
WL
I
F
A
AF
M
F
GT
GYE
K
TGLGRRIAL
I
LVKKMG
H
RTL
F
LGYA
V
M
F
S
E
L
I
LAP
V
TPSN
S
AR
G
A
GI
I
Y
PII
R
NLPPL
YQ
S
Q
PNDSS
S
R
S
IG
S
Y
I
MWM
GI
V
A
D
CV
TS
A
I
F
L
TAMAPNLL
L
I
GL
M
KS
A
S
H
A
--
TL
SWG
D
WFL
GM
LP
L
S
I
L
L
V
L
L
V
PWL
A
YVLYPP
VL
K
SG
D
Q
V
P
R
WA
ET
EL
QA
MGPL
CS
REK
R
M
LGL
M
V
G
AL
V
LWIFG
GDY
--
IDA
A
M
VG
YS
VVALMLL
--
L
R
I
I
S
W
D
DIV
S
NK
A
AWN
VF
F
WLA
S
LI
T
LA
T
GL
N
NT
GFI
S
WF
G
KLLAG
S
L
S
G
Y
SP
TM
----
VMV
A
LI
V
VFY
LL
RYFFAS
A
T
AYT
S
A
LA
P
M
MI
A
A
A
LAM
P
---
E
I
PL
PVF
CL
M
V
GA
A
IG
L
G
S
I
LTPYATGP
S
PI
Y
YG
S
GY
LPTA
DYWRLGAIFG
L
I
-
FLVLL
V
I
T
G
fig|344610.7.peg.3182
Escherichia coli 53638 (11-478/487)
LAPLAV
IA
II
A
LIP
V
PAGL
ESH
T
W
L
YFAVF
T
G
V
IVGLILEP
V
P
GA
VV
AM
VGI
S
I
IA
I
L
S
PW
LLF
SPEQ
LA
Q
P
G
F
KFT
A
KS
L
S
W
A
V
SGFS
N
S
V
I
WL
I
F
A
AF
M
F
GT
GYE
K
TGLGRRIAL
I
LVKKMG
H
RTL
F
LGYA
V
M
F
S
E
L
I
LAP
V
TPSN
S
AR
G
A
GI
I
Y
PII
R
NLPPL
YQ
S
Q
PNDSS
S
R
S
IG
S
Y
I
MWM
GI
V
A
D
CV
TS
A
I
F
L
TAMAPNLL
L
I
GL
M
KS
A
S
H
A
--
TL
SWG
D
WFL
GM
LP
L
S
I
L
L
V
L
L
V
PWL
A
YVLYPP
VL
K
SG
D
Q
V
P
R
WA
ET
EL
QA
MGPL
CS
REK
R
M
LGL
M
V
G
AL
V
LWIFG
GDY
--
IDA
A
M
VG
YS
VVALMLL
--
L
R
I
I
S
W
D
DIV
S
NK
A
AWN
VF
F
WLA
S
LI
T
LA
T
GL
N
NT
GFI
S
WF
G
KLLAG
S
L
S
G
Y
SP
TM
----
VMV
A
LI
V
VFY
LL
RYFFAS
A
T
AYT
S
A
LA
P
M
MI
A
A
A
LAM
P
---
E
I
PL
PVF
CL
M
V
GA
A
IG
L
G
S
I
LTPYATGP
S
PI
Y
YG
S
GY
LPTA
DYWRLGAIFG
L
I
-
FLVLL
V
I
T
G
fig|562.374.peg.4635
Escherichia coli 536A (11-478/487)
LAPLAV
IA
II
A
LIP
V
PAGL
ESH
T
W
L
YFAVF
T
G
V
IVGLILEP
V
P
GA
VV
AM
VGI
S
I
IA
I
L
S
PW
LLF
SPEQ
LA
Q
P
G
F
KFT
A
KS
L
S
W
A
V
SGFS
N
S
V
I
WL
I
F
A
AF
M
F
GT
GYE
K
TGLGRRIAL
I
LVKKMG
H
RTL
F
LGYA
V
M
F
S
E
L
I
LAP
V
TPSN
S
AR
G
A
GI
I
Y
PII
R
NLPPL
YQ
S
Q
PNDSS
S
R
S
IG
S
Y
I
MWM
GI
V
A
D
CV
TS
A
I
F
L
TAMAPNLL
L
I
GL
M
KS
A
S
H
A
--
TL
SWG
D
WFL
GM
LP
L
S
I
L
L
V
L
L
V
PWL
A
YVLYPP
VL
K
SG
D
Q
V
P
R
WA
ET
EL
QA
MGPL
CS
REK
R
M
LGL
M
V
G
AL
V
LWIFG
GDY
--
IDA
A
M
VG
YS
VVALMLL
--
L
R
I
I
S
W
D
DIV
S
NK
A
AWN
VF
F
WLA
S
LI
T
LA
T
GL
N
NT
GFI
S
WF
G
KLLAG
S
L
S
G
Y
SP
TM
----
VMV
A
LI
V
VFY
LL
RYFFAS
A
T
AYT
S
A
LA
P
M
MI
A
A
A
LAM
P
---
E
I
PL
PVF
CL
M
V
GA
A
IG
L
G
S
I
LTPYATGP
S
PI
Y
YG
S
GY
LPTA
DYWRLGAIFG
L
I
-
FLVLL
V
I
T
G
fig|679204.3.peg.788
Escherichia coli MS 145-7 (11-478/487)
LAPLAV
IA
II
A
LIP
V
PAGL
ESH
T
W
L
YFAVF
T
G
V
IVGLILEP
V
P
GA
VV
AM
VGI
S
I
IA
I
L
S
PW
LLF
SPEQ
LA
Q
P
G
F
KFT
A
KS
L
S
W
A
V
SGFS
N
S
V
I
WL
I
F
A
AF
M
F
GT
GYE
K
TGLGRRIAL
I
LVKKMG
H
RTL
F
LGYA
V
M
F
S
E
L
I
LAP
V
TPSN
S
AR
G
A
GI
I
Y
PII
R
NLPPL
YQ
S
Q
PNDSS
S
R
S
IG
S
Y
I
MWM
GI
V
A
D
CV
TS
A
I
F
L
TAMAPNLL
L
I
GL
M
KS
A
S
H
A
--
TL
SWG
D
WFL
GM
LP
L
S
I
L
L
V
L
L
V
PWL
A
YVLYPP
VL
K
SG
D
Q
V
P
R
WA
ET
EL
QA
MGPL
CS
REK
R
M
LGL
M
V
G
AL
V
LWIFG
GDY
--
IDA
A
M
VG
YS
VVALMLL
--
L
R
I
I
S
W
D
DIV
S
NK
A
AWN
VF
F
WLA
S
LI
T
LA
T
GL
N
NT
GFI
S
WF
G
KLLAG
S
L
S
G
Y
SP
TM
----
VMV
A
LI
V
VFY
LL
RYFFAS
A
T
AYT
S
A
LA
P
M
MI
A
A
A
LAM
P
---
E
I
PL
PVF
CL
M
V
GA
A
IG
L
G
S
I
LTPYATGP
S
PI
Y
YG
S
GY
LPTA
DYWRLGAIFG
L
I
-
FLVLL
V
I
T
G
fig|83334.1.peg.3920
Escherichia coli O157:H7 (11-478/487)
LAPLAV
IA
II
A
LIP
V
PAGL
ESH
T
W
L
YFAVF
T
G
V
IVGLILEP
V
P
GA
VV
AM
VGI
S
I
IA
I
L
S
PW
LLF
SPEQ
LA
Q
P
G
F
KFT
A
KS
L
S
W
A
V
SGFS
N
S
V
I
WL
I
F
A
AF
M
F
GT
GYE
K
TGLGRRIAL
I
LVKKMG
H
RTL
F
LGYA
V
M
F
S
E
L
I
LAP
V
TPSN
S
AR
G
A
GI
I
Y
PII
R
NLPPL
YQ
S
Q
PNDSS
S
R
S
IG
S
Y
I
MWM
GI
V
A
D
CV
TS
A
I
F
L
TAMAPNLL
L
I
GL
M
KS
A
S
H
A
--
TL
SWG
D
WFL
GM
LP
L
S
I
L
L
V
L
L
V
PWL
A
YVLYPP
VL
K
SG
D
Q
V
P
R
WA
ET
EL
QA
MGPL
CS
REK
R
M
LGL
M
V
G
AL
V
LWIFG
GDY
--
IDA
A
M
VG
YS
VVALMLL
--
L
R
I
I
S
W
D
DIV
S
NK
A
AWN
VF
F
WLA
S
LI
T
LA
T
GL
N
NT
GFI
S
WF
G
KLLAG
S
L
S
G
Y
SP
TM
----
VMV
A
LI
V
VFY
LL
RYFFAS
A
T
AYT
S
A
LA
P
M
MI
A
A
A
LAM
P
---
E
I
PL
PVF
CL
M
V
GA
A
IG
L
G
S
I
LTPYATGP
S
PI
Y
YG
S
GY
LPTA
DYWRLGAIFG
L
I
-
FLVLL
V
I
T
G
fig|155864.1.peg.3946
Escherichia coli O157:H7 EDL933 (11-478/487)
LAPLAV
IA
II
A
LIP
V
PAGL
ESH
T
W
L
YFAVF
T
G
V
IVGLILEP
V
P
GA
VV
AM
VGI
S
I
IA
I
L
S
PW
LLF
SPEQ
LA
Q
P
G
F
KFT
A
KS
L
S
W
A
V
SGFS
N
S
V
I
WL
I
F
A
AF
M
F
GT
GYE
K
TGLGRRIAL
I
LVKKMG
H
RTL
F
LGYA
V
M
F
S
E
L
I
LAP
V
TPSN
S
AR
G
A
GI
I
Y
PII
R
NLPPL
YQ
S
Q
PNDSS
S
R
S
IG
S
Y
I
MWM
GI
V
A
D
CV
TS
A
I
F
L
TAMAPNLL
L
I
GL
M
KS
A
S
H
A
--
TL
SWG
D
WFL
GM
LP
L
S
I
L
L
V
L
L
V
PWL
A
YVLYPP
VL
K
SG
D
Q
V
P
R
WA
ET
EL
QA
MGPL
CS
REK
R
M
LGL
M
V
G
AL
V
LWIFG
GDY
--
IDA
A
M
VG
YS
VVALMLL
--
L
R
I
I
S
W
D
DIV
S
NK
A
AWN
VF
F
WLA
S
LI
T
LA
T
GL
N
NT
GFI
S
WF
G
KLLAG
S
L
S
G
Y
SP
TM
----
VMV
A
LI
V
VFY
LL
RYFFAS
A
T
AYT
S
A
LA
P
M
MI
A
A
A
LAM
P
---
E
I
PL
PVF
CL
M
V
GA
A
IG
L
G
S
I
LTPYATGP
S
PI
Y
YG
S
GY
LPTA
DYWRLGAIFG
L
I
-
FLVLL
V
I
T
G
fig|155864.8.peg.3871
Escherichia coli O157:H7 EDL933 (11-478/487)
LAPLAV
IA
II
A
LIP
V
PAGL
ESH
T
W
L
YFAVF
T
G
V
IVGLILEP
V
P
GA
VV
AM
VGI
S
I
IA
I
L
S
PW
LLF
SPEQ
LA
Q
P
G
F
KFT
A
KS
L
S
W
A
V
SGFS
N
S
V
I
WL
I
F
A
AF
M
F
GT
GYE
K
TGLGRRIAL
I
LVKKMG
H
RTL
F
LGYA
V
M
F
S
E
L
I
LAP
V
TPSN
S
AR
G
A
GI
I
Y
PII
R
NLPPL
YQ
S
Q
PNDSS
S
R
S
IG
S
Y
I
MWM
GI
V
A
D
CV
TS
A
I
F
L
TAMAPNLL
L
I
GL
M
KS
A
S
H
A
--
TL
SWG
D
WFL
GM
LP
L
S
I
L
L
V
L
L
V
PWL
A
YVLYPP
VL
K
SG
D
Q
V
P
R
WA
ET
EL
QA
MGPL
CS
REK
R
M
LGL
M
V
G
AL
V
LWIFG
GDY
--
IDA
A
M
VG
YS
VVALMLL
--
L
R
I
I
S
W
D
DIV
S
NK
A
AWN
VF
F
WLA
S
LI
T
LA
T
GL
N
NT
GFI
S
WF
G
KLLAG
S
L
S
G
Y
SP
TM
----
VMV
A
LI
V
VFY
LL
RYFFAS
A
T
AYT
S
A
LA
P
M
MI
A
A
A
LAM
P
---
E
I
PL
PVF
CL
M
V
GA
A
IG
L
G
S
I
LTPYATGP
S
PI
Y
YG
S
GY
LPTA
DYWRLGAIFG
L
I
-
FLVLL
V
I
T
G
fig|444454.5.peg.2995
Escherichia coli O157:H7 str. EC4024 (11-478/487)
LAPLAV
IA
II
A
LIP
V
PAGL
ESH
T
W
L
YFAVF
T
G
V
IVGLILEP
V
P
GA
VV
AM
VGI
S
I
IA
I
L
S
PW
LLF
SPEQ
LA
Q
P
G
F
KFT
A
KS
L
S
W
A
V
SGFS
N
S
V
I
WL
I
F
A
AF
M
F
GT
GYE
K
TGLGRRIAL
I
LVKKMG
H
RTL
F
LGYA
V
M
F
S
E
L
I
LAP
V
TPSN
S
AR
G
A
GI
I
Y
PII
R
NLPPL
YQ
S
Q
PNDSS
S
R
S
IG
S
Y
I
MWM
GI
V
A
D
CV
TS
A
I
F
L
TAMAPNLL
L
I
GL
M
KS
A
S
H
A
--
TL
SWG
D
WFL
GM
LP
L
S
I
L
L
V
L
L
V
PWL
A
YVLYPP
VL
K
SG
D
Q
V
P
R
WA
ET
EL
QA
MGPL
CS
REK
R
M
LGL
M
V
G
AL
V
LWIFG
GDY
--
IDA
A
M
VG
YS
VVALMLL
--
L
R
I
I
S
W
D
DIV
S
NK
A
AWN
VF
F
WLA
S
LI
T
LA
T
GL
N
NT
GFI
S
WF
G
KLLAG
S
L
S
G
Y
SP
TM
----
VMV
A
LI
V
VFY
LL
RYFFAS
A
T
AYT
S
A
LA
P
M
MI
A
A
A
LAM
P
---
E
I
PL
PVF
CL
M
V
GA
A
IG
L
G
S
I
LTPYATGP
S
PI
Y
YG
S
GY
LPTA
DYWRLGAIFG
L
I
-
FLVLL
V
I
T
G
fig|444449.5.peg.2453
Escherichia coli O157:H7 str. EC4042 (11-478/487)
LAPLAV
IA
II
A
LIP
V
PAGL
ESH
T
W
L
YFAVF
T
G
V
IVGLILEP
V
P
GA
VV
AM
VGI
S
I
IA
I
L
S
PW
LLF
SPEQ
LA
Q
P
G
F
KFT
A
KS
L
S
W
A
V
SGFS
N
S
V
I
WL
I
F
A
AF
M
F
GT
GYE
K
TGLGRRIAL
I
LVKKMG
H
RTL
F
LGYA
V
M
F
S
E
L
I
LAP
V
TPSN
S
AR
G
A
GI
I
Y
PII
R
NLPPL
YQ
S
Q
PNDSS
S
R
S
IG
S
Y
I
MWM
GI
V
A
D
CV
TS
A
I
F
L
TAMAPNLL
L
I
GL
M
KS
A
S
H
A
--
TL
SWG
D
WFL
GM
LP
L
S
I
L
L
V
L
L
V
PWL
A
YVLYPP
VL
K
SG
D
Q
V
P
R
WA
ET
EL
QA
MGPL
CS
REK
R
M
LGL
M
V
G
AL
V
LWIFG
GDY
--
IDA
A
M
VG
YS
VVALMLL
--
L
R
I
I
S
W
D
DIV
S
NK
A
AWN
VF
F
WLA
S
LI
T
LA
T
GL
N
NT
GFI
S
WF
G
KLLAG
S
L
S
G
Y
SP
TM
----
VMV
A
LI
V
VFY
LL
RYFFAS
A
T
AYT
S
A
LA
P
M
MI
A
A
A
LAM
P
---
E
I
PL
PVF
CL
M
V
GA
A
IG
L
G
S
I
LTPYATGP
S
PI
Y
YG
S
GY
LPTA
DYWRLGAIFG
L
I
-
FLVLL
V
I
T
G
fig|444448.5.peg.1206
Escherichia coli O157:H7 str. EC4045 (11-478/487)
LAPLAV
IA
II
A
LIP
V
PAGL
ESH
T
W
L
YFAVF
T
G
V
IVGLILEP
V
P
GA
VV
AM
VGI
S
I
IA
I
L
S
PW
LLF
SPEQ
LA
Q
P
G
F
KFT
A
KS
L
S
W
A
V
SGFS
N
S
V
I
WL
I
F
A
AF
M
F
GT
GYE
K
TGLGRRIAL
I
LVKKMG
H
RTL
F
LGYA
V
M
F
S
E
L
I
LAP
V
TPSN
S
AR
G
A
GI
I
Y
PII
R
NLPPL
YQ
S
Q
PNDSS
S
R
S
IG
S
Y
I
MWM
GI
V
A
D
CV
TS
A
I
F
L
TAMAPNLL
L
I
GL
M
KS
A
S
H
A
--
TL
SWG
D
WFL
GM
LP
L
S
I
L
L
V
L
L
V
PWL
A
YVLYPP
VL
K
SG
D
Q
V
P
R
WA
ET
EL
QA
MGPL
CS
REK
R
M
LGL
M
V
G
AL
V
LWIFG
GDY
--
IDA
A
M
VG
YS
VVALMLL
--
L
R
I
I
S
W
D
DIV
S
NK
A
AWN
VF
F
WLA
S
LI
T
LA
T
GL
N
NT
GFI
S
WF
G
KLLAG
S
L
S
G
Y
SP
TM
----
VMV
A
LI
V
VFY
LL
RYFFAS
A
T
AYT
S
A
LA
P
M
MI
A
A
A
LAM
P
---
E
I
PL
PVF
CL
M
V
GA
A
IG
L
G
S
I
LTPYATGP
S
PI
Y
YG
S
GY
LPTA
DYWRLGAIFG
L
I
-
FLVLL
V
I
T
G
fig|444453.5.peg.3334
Escherichia coli O157:H7 str. EC4076 (11-478/487)
LAPLAV
IA
II
A
LIP
V
PAGL
ESH
T
W
L
YFAVF
T
G
V
IVGLILEP
V
P
GA
VV
AM
VGI
S
I
IA
I
L
S
PW
LLF
SPEQ
LA
Q
P
G
F
KFT
A
KS
L
S
W
A
V
SGFS
N
S
V
I
WL
I
F
A
AF
M
F
GT
GYE
K
TGLGRRIAL
I
LVKKMG
H
RTL
F
LGYA
V
M
F
S
E
L
I
LAP
V
TPSN
S
AR
G
A
GI
I
Y
PII
R
NLPPL
YQ
S
Q
PNDSS
S
R
S
IG
S
Y
I
MWM
GI
V
A
D
CV
TS
A
I
F
L
TAMAPNLL
L
I
GL
M
KS
A
S
H
A
--
TL
SWG
D
WFL
GM
LP
L
S
I
L
L
V
L
L
V
PWL
A
YVLYPP
VL
K
SG
D
Q
V
P
R
WA
ET
EL
QA
MGPL
CS
REK
R
M
LGL
M
V
G
AL
V
LWIFG
GDY
--
IDA
A
M
VG
YS
VVALMLL
--
L
R
I
I
S
W
D
DIV
S
NK
A
AWN
VF
F
WLA
S
LI
T
LA
T
GL
N
NT
GFI
S
WF
G
KLLAG
S
L
S
G
Y
SP
TM
----
VMV
A
LI
V
VFY
LL
RYFFAS
A
T
AYT
S
A
LA
P
M
MI
A
A
A
LAM
P
---
E
I
PL
PVF
CL
M
V
GA
A
IG
L
G
S
I
LTPYATGP
S
PI
Y
YG
S
GY
LPTA
DYWRLGAIFG
L
I
-
FLVLL
V
I
T
G
fig|444452.5.peg.5517
Escherichia coli O157:H7 str. EC4113 (11-478/487)
LAPLAV
IA
II
A
LIP
V
PAGL
ESH
T
W
L
YFAVF
T
G
V
IVGLILEP
V
P
GA
VV
AM
VGI
S
I
IA
I
L
S
PW
LLF
SPEQ
LA
Q
P
G
F
KFT
A
KS
L
S
W
A
V
SGFS
N
S
V
I
WL
I
F
A
AF
M
F
GT
GYE
K
TGLGRRIAL
I
LVKKMG
H
RTL
F
LGYA
V
M
F
S
E
L
I
LAP
V
TPSN
S
AR
G
A
GI
I
Y
PII
R
NLPPL
YQ
S
Q
PNDSS
S
R
S
IG
S
Y
I
MWM
GI
V
A
D
CV
TS
A
I
F
L
TAMAPNLL
L
I
GL
M
KS
A
S
H
A
--
TL
SWG
D
WFL
GM
LP
L
S
I
L
L
V
L
L
V
PWL
A
YVLYPP
VL
K
SG
D
Q
V
P
R
WA
ET
EL
QA
MGPL
CS
REK
R
M
LGL
M
V
G
AL
V
LWIFG
GDY
--
IDA
A
M
VG
YS
VVALMLL
--
L
R
I
I
S
W
D
DIV
S
NK
A
AWN
VF
F
WLA
S
LI
T
LA
T
GL
N
NT
GFI
S
WF
G
KLLAG
S
L
S
G
Y
SP
TM
----
VMV
A
LI
V
VFY
LL
RYFFAS
A
T
AYT
S
A
LA
P
M
MI
A
A
A
LAM
P
---
E
I
PL
PVF
CL
M
V
GA
A
IG
L
G
S
I
LTPYATGP
S
PI
Y
YG
S
GY
LPTA
DYWRLGAIFG
L
I
-
FLVLL
V
I
T
G
fig|444450.8.peg.4290
Escherichia coli O157:H7 str. EC4115 (11-478/487)
LAPLAV
IA
II
A
LIP
V
PAGL
ESH
T
W
L
YFAVF
T
G
V
IVGLILEP
V
P
GA
VV
AM
VGI
S
I
IA
I
L
S
PW
LLF
SPEQ
LA
Q
P
G
F
KFT
A
KS
L
S
W
A
V
SGFS
N
S
V
I
WL
I
F
A
AF
M
F
GT
GYE
K
TGLGRRIAL
I
LVKKMG
H
RTL
F
LGYA
V
M
F
S
E
L
I
LAP
V
TPSN
S
AR
G
A
GI
I
Y
PII
R
NLPPL
YQ
S
Q
PNDSS
S
R
S
IG
S
Y
I
MWM
GI
V
A
D
CV
TS
A
I
F
L
TAMAPNLL
L
I
GL
M
KS
A
S
H
A
--
TL
SWG
D
WFL
GM
LP
L
S
I
L
L
V
L
L
V
PWL
A
YVLYPP
VL
K
SG
D
Q
V
P
R
WA
ET
EL
QA
MGPL
CS
REK
R
M
LGL
M
V
G
AL
V
LWIFG
GDY
--
IDA
A
M
VG
YS
VVALMLL
--
L
R
I
I
S
W
D
DIV
S
NK
A
AWN
VF
F
WLA
S
LI
T
LA
T
GL
N
NT
GFI
S
WF
G
KLLAG
S
L
S
G
Y
SP
TM
----
VMV
A
LI
V
VFY
LL
RYFFAS
A
T
AYT
S
A
LA
P
M
MI
A
A
A
LAM
P
---
E
I
PL
PVF
CL
M
V
GA
A
IG
L
G
S
I
LTPYATGP
S
PI
Y
YG
S
GY
LPTA
DYWRLGAIFG
L
I
-
FLVLL
V
I
T
G
fig|444451.5.peg.990
Escherichia coli O157:H7 str. EC4196 (11-478/487)
LAPLAV
IA
II
A
LIP
V
PAGL
ESH
T
W
L
YFAVF
T
G
V
IVGLILEP
V
P
GA
VV
AM
VGI
S
I
IA
I
L
S
PW
LLF
SPEQ
LA
Q
P
G
F
KFT
A
KS
L
S
W
A
V
SGFS
N
S
V
I
WL
I
F
A
AF
M
F
GT
GYE
K
TGLGRRIAL
I
LVKKMG
H
RTL
F
LGYA
V
M
F
S
E
L
I
LAP
V
TPSN
S
AR
G
A
GI
I
Y
PII
R
NLPPL
YQ
S
Q
PNDSS
S
R
S
IG
S
Y
I
MWM
GI
V
A
D
CV
TS
A
I
F
L
TAMAPNLL
L
I
GL
M
KS
A
S
H
A
--
TL
SWG
D
WFL
GM
LP
L
S
I
L
L
V
L
L
V
PWL
A
YVLYPP
VL
K
SG
D
Q
V
P
R
WA
ET
EL
QA
MGPL
CS
REK
R
M
LGL
M
V
G
AL
V
LWIFG
GDY
--
IDA
A
M
VG
YS
VVALMLL
--
L
R
I
I
S
W
D
DIV
S
NK
A
AWN
VF
F
WLA
S
LI
T
LA
T
GL
N
NT
GFI
S
WF
G
KLLAG
S
L
S
G
Y
SP
TM
----
VMV
A
LI
V
VFY
LL
RYFFAS
A
T
AYT
S
A
LA
P
M
MI
A
A
A
LAM
P
---
E
I
PL
PVF
CL
M
V
GA
A
IG
L
G
S
I
LTPYATGP
S
PI
Y
YG
S
GY
LPTA
DYWRLGAIFG
L
I
-
FLVLL
V
I
T
G
fig|444447.5.peg.1363
Escherichia coli O157:H7 str. EC4206 (11-478/487)
LAPLAV
IA
II
A
LIP
V
PAGL
ESH
T
W
L
YFAVF
T
G
V
IVGLILEP
V
P
GA
VV
AM
VGI
S
I
IA
I
L
S
PW
LLF
SPEQ
LA
Q
P
G
F
KFT
A
KS
L
S
W
A
V
SGFS
N
S
V
I
WL
I
F
A
AF
M
F
GT
GYE
K
TGLGRRIAL
I
LVKKMG
H
RTL
F
LGYA
V
M
F
S
E
L
I
LAP
V
TPSN
S
AR
G
A
GI
I
Y
PII
R
NLPPL
YQ
S
Q
PNDSS
S
R
S
IG
S
Y
I
MWM
GI
V
A
D
CV
TS
A
I
F
L
TAMAPNLL
L
I
GL
M
KS
A
S
H
A
--
TL
SWG
D
WFL
GM
LP
L
S
I
L
L
V
L
L
V
PWL
A
YVLYPP
VL
K
SG
D
Q
V
P
R
WA
ET
EL
QA
MGPL
CS
REK
R
M
LGL
M
V
G
AL
V
LWIFG
GDY
--
IDA
A
M
VG
YS
VVALMLL
--
L
R
I
I
S
W
D
DIV
S
NK
A
AWN
VF
F
WLA
S
LI
T
LA
T
GL
N
NT
GFI
S
WF
G
KLLAG
S
L
S
G
Y
SP
TM
----
VMV
A
LI
V
VFY
LL
RYFFAS
A
T
AYT
S
A
LA
P
M
MI
A
A
A
LAM
P
---
E
I
PL
PVF
CL
M
V
GA
A
IG
L
G
S
I
LTPYATGP
S
PI
Y
YG
S
GY
LPTA
DYWRLGAIFG
L
I
-
FLVLL
V
I
T
G
fig|478004.5.peg.891
Escherichia coli O157:H7 str. EC4401 (11-478/487)
LAPLAV
IA
II
A
LIP
V
PAGL
ESH
T
W
L
YFAVF
T
G
V
IVGLILEP
V
P
GA
VV
AM
VGI
S
I
IA
I
L
S
PW
LLF
SPEQ
LA
Q
P
G
F
KFT
A
KS
L
S
W
A
V
SGFS
N
S
V
I
WL
I
F
A
AF
M
F
GT
GYE
K
TGLGRRIAL
I
LVKKMG
H
RTL
F
LGYA
V
M
F
S
E
L
I
LAP
V
TPSN
S
AR
G
A
GI
I
Y
PII
R
NLPPL
YQ
S
Q
PNDSS
S
R
S
IG
S
Y
I
MWM
GI
V
A
D
CV
TS
A
I
F
L
TAMAPNLL
L
I
GL
M
KS
A
S
H
A
--
TL
SWG
D
WFL
GM
LP
L
S
I
L
L
V
L
L
V
PWL
A
YVLYPP
VL
K
SG
D
Q
V
P
R
WA
ET
EL
QA
MGPL
CS
REK
R
M
LGL
M
V
G
AL
V
LWIFG
GDY
--
IDA
A
M
VG
YS
VVALMLL
--
L
R
I
I
S
W
D
DIV
S
NK
A
AWN
VF
F
WLA
S
LI
T
LA
T
GL
N
NT
GFI
S
WF
G
KLLAG
S
L
S
G
Y
SP
TM
----
VMV
A
LI
V
VFY
LL
RYFFAS
A
T
AYT
S
A
LA
P
M
MI
A
A
A
LAM
P
---
E
I
PL
PVF
CL
M
V
GA
A
IG
L
G
S
I
LTPYATGP
S
PI
Y
YG
S
GY
LPTA
DYWRLGAIFG
L
I
-
FLVLL
V
I
T
G
fig|478006.5.peg.780
Escherichia coli O157:H7 str. EC4501 (11-478/487)
LAPLAV
IA
II
A
LIP
V
PAGL
ESH
T
W
L
YFAVF
T
G
V
IVGLILEP
V
P
GA
VV
AM
VGI
S
I
IA
I
L
S
PW
LLF
SPEQ
LA
Q
P
G
F
KFT
A
KS
L
S
W
A
V
SGFS
N
S
V
I
WL
I
F
A
AF
M
F
GT
GYE
K
TGLGRRIAL
I
LVKKMG
H
RTL
F
LGYA
V
M
F
S
E
L
I
LAP
V
TPSN
S
AR
G
A
GI
I
Y
PII
R
NLPPL
YQ
S
Q
PNDSS
S
R
S
IG
S
Y
I
MWM
GI
V
A
D
CV
TS
A
I
F
L
TAMAPNLL
L
I
GL
M
KS
A
S
H
A
--
TL
SWG
D
WFL
GM
LP
L
S
I
L
L
V
L
L
V
PWL
A
YVLYPP
VL
K
SG
D
Q
V
P
R
WA
ET
EL
QA
MGPL
CS
REK
R
M
LGL
M
V
G
AL
V
LWIFG
GDY
--
IDA
A
M
VG
YS
VVALMLL
--
L
R
I
I
S
W
D
DIV
S
NK
A
AWN
VF
F
WLA
S
LI
T
LA
T
GL
N
NT
GFI
S
WF
G
KLLAG
S
L
S
G
Y
SP
TM
----
VMV
A
LI
V
VFY
LL
RYFFAS
A
T
AYT
S
A
LA
P
M
MI
A
A
A
LAM
P
---
E
I
PL
PVF
CL
M
V
GA
A
IG
L
G
S
I
LTPYATGP
S
PI
Y
YG
S
GY
LPTA
DYWRLGAIFG
L
I
-
FLVLL
V
I
T
G
fig|478007.5.peg.514
Escherichia coli O157:H7 str. EC508 (11-478/487)
LAPLAV
IA
II
A
LIP
V
PAGL
ESH
T
W
L
YFAVF
T
G
V
IVGLILEP
V
P
GA
VV
AM
VGI
S
I
IA
I
L
S
PW
LLF
SPEQ
LA
Q
P
G
F
KFT
A
KS
L
S
W
A
V
SGFS
N
S
V
I
WL
I
F
A
AF
M
F
GT
GYE
K
TGLGRRIAL
I
LVKKMG
H
RTL
F
LGYA
V
M
F
S
E
L
I
LAP
V
TPSN
S
AR
G
A
GI
I
Y
PII
R
NLPPL
YQ
S
Q
PNDSS
S
R
S
IG
S
Y
I
MWM
GI
V
A
D
CV
TS
A
I
F
L
TAMAPNLL
L
I
GL
M
KS
A
S
H
A
--
TL
SWG
D
WFL
GM
LP
L
S
I
L
L
V
L
L
V
PWL
A
YVLYPP
VL
K
SG
D
Q
V
P
R
WA
ET
EL
QA
MGPL
CS
REK
R
M
LGL
M
V
G
AL
V
LWIFG
GDY
--
IDA
A
M
VG
YS
VVALMLL
--
L
R
I
I
S
W
D
DIV
S
NK
A
AWN
VF
F
WLA
S
LI
T
LA
T
GL
N
NT
GFI
S
WF
G
KLLAG
S
L
S
G
Y
SP
TM
----
VMV
A
LI
V
VFY
LL
RYFFAS
A
T
AYT
S
A
LA
P
M
MI
A
A
A
LAM
P
---
E
I
PL
PVF
CL
M
V
GA
A
IG
L
G
S
I
LTPYATGP
S
PI
Y
YG
S
GY
LPTA
DYWRLGAIFG
L
I
-
FLVLL
V
I
T
G
fig|478008.5.peg.1263
Escherichia coli O157:H7 str. EC869 (11-478/487)
LAPLAV
IA
II
A
LIP
V
PAGL
ESH
T
W
L
YFAVF
T
G
V
IVGLILEP
V
P
GA
VV
AM
VGI
S
I
IA
I
L
S
PW
LLF
SPEQ
LA
Q
P
G
F
KFT
A
KS
L
S
W
A
V
SGFS
N
S
V
I
WL
I
F
A
AF
M
F
GT
GYE
K
TGLGRRIAL
I
LVKKMG
H
RTL
F
LGYA
V
M
F
S
E
L
I
LAP
V
TPSN
S
AR
G
A
GI
I
Y
PII
R
NLPPL
YQ
S
Q
PNDSS
S
R
S
IG
S
Y
I
MWM
GI
V
A
D
CV
TS
A
I
F
L
TAMAPNLL
L
I
GL
M
KS
A
S
H
A
--
TL
SWG
D
WFL
GM
LP
L
S
I
L
L
V
L
L
V
PWL
A
YVLYPP
VL
K
SG
D
Q
V
P
R
WA
ET
EL
QA
MGPL
CS
REK
R
M
LGL
M
V
G
AL
V
LWIFG
GDY
--
IDA
A
M
VG
YS
VVALMLL
--
L
R
I
I
S
W
D
DIV
S
NK
A
AWN
VF
F
WLA
S
LI
T
LA
T
GL
N
NT
GFI
S
WF
G
KLLAG
S
L
S
G
Y
SP
TM
----
VMV
A
LI
V
VFY
LL
RYFFAS
A
T
AYT
S
A
LA
P
M
MI
A
A
A
LAM
P
---
E
I
PL
PVF
CL
M
V
GA
A
IG
L
G
S
I
LTPYATGP
S
PI
Y
YG
S
GY
LPTA
DYWRLGAIFG
L
I
-
FLVLL
V
I
T
G
fig|637388.3.peg.5155
Escherichia coli O157:H7 str. FRIK2000 (11-478/487)
LAPLAV
IA
II
A
LIP
V
PAGL
ESH
T
W
L
YFAVF
T
G
V
IVGLILEP
V
P
GA
VV
AM
VGI
S
I
IA
I
L
S
PW
LLF
SPEQ
LA
Q
P
G
F
KFT
A
KS
L
S
W
A
V
SGFS
N
S
V
I
WL
I
F
A
AF
M
F
GT
GYE
K
TGLGRRIAL
I
LVKKMG
H
RTL
F
LGYA
V
M
F
S
E
L
I
LAP
V
TPSN
S
AR
G
A
GI
I
Y
PII
R
NLPPL
YQ
S
Q
PNDSS
S
R
S
IG
S
Y
I
MWM
GI
V
A
D
CV
TS
A
I
F
L
TAMAPNLL
L
I
GL
M
KS
A
S
H
A
--
TL
SWG
D
WFL
GM
LP
L
S
I
L
L
V
L
L
V
PWL
A
YVLYPP
VL
K
SG
D
Q
V
P
R
WA
ET
EL
QA
MGPL
CS
REK
R
M
LGL
M
V
G
AL
V
LWIFG
GDY
--
IDA
A
M
VG
YS
VVALMLL
--
L
R
I
I
S
W
D
DIV
S
NK
A
AWN
VF
F
WLA
S
LI
T
LA
T
GL
N
NT
GFI
S
WF
G
KLLAG
S
L
S
G
Y
SP
TM
----
VMV
A
LI
V
VFY
LL
RYFFAS
A
T
AYT
S
A
LA
P
M
MI
A
A
A
LAM
P
---
E
I
PL
PVF
CL
M
V
GA
A
IG
L
G
S
I
LTPYATGP
S
PI
Y
YG
S
GY
LPTA
DYWRLGAIFG
L
I
-
FLVLL
V
I
T
G
fig|570506.3.peg.759
Escherichia coli O157:H7 str. FRIK966 (11-478/487)
LAPLAV
IA
II
A
LIP
V
PAGL
ESH
T
W
L
YFAVF
T
G
V
IVGLILEP
V
P
GA
VV
AM
VGI
S
I
IA
I
L
S
PW
LLF
SPEQ
LA
Q
P
G
F
KFT
A
KS
L
S
W
A
V
SGFS
N
S
V
I
WL
I
F
A
AF
M
F
GT
GYE
K
TGLGRRIAL
I
LVKKMG
H
RTL
F
LGYA
V
M
F
S
E
L
I
LAP
V
TPSN
S
AR
G
A
GI
I
Y
PII
R
NLPPL
YQ
S
Q
PNDSS
S
R
S
IG
S
Y
I
MWM
GI
V
A
D
CV
TS
A
I
F
L
TAMAPNLL
L
I
GL
M
KS
A
S
H
A
--
TL
SWG
D
WFL
GM
LP
L
S
I
L
L
V
L
L
V
PWL
A
YVLYPP
VL
K
SG
D
Q
V
P
R
WA
ET
EL
QA
MGPL
CS
REK
R
M
LGL
M
V
G
AL
V
LWIFG
GDY
--
IDA
A
M
VG
YS
VVALMLL
--
L
R
I
I
S
W
D
DIV
S
NK
A
AWN
VF
F
WLA
S
LI
T
LA
T
GL
N
NT
GFI
S
WF
G
KLLAG
S
L
S
G
Y
SP
TM
----
VMV
A
LI
V
VFY
LL
RYFFAS
A
T
AYT
S
A
LA
P
M
MI
A
A
A
LAM
P
---
E
I
PL
PVF
CL
M
V
GA
A
IG
L
G
S
I
LTPYATGP
S
PI
Y
YG
S
GY
LPTA
DYWRLGAIFG
L
I
-
FLVLL
V
I
T
G
fig|386585.9.peg.4116
Escherichia coli O157:H7 str. Sakai (11-478/487)
LAPLAV
IA
II
A
LIP
V
PAGL
ESH
T
W
L
YFAVF
T
G
V
IVGLILEP
V
P
GA
VV
AM
VGI
S
I
IA
I
L
S
PW
LLF
SPEQ
LA
Q
P
G
F
KFT
A
KS
L
S
W
A
V
SGFS
N
S
V
I
WL
I
F
A
AF
M
F
GT
GYE
K
TGLGRRIAL
I
LVKKMG
H
RTL
F
LGYA
V
M
F
S
E
L
I
LAP
V
TPSN
S
AR
G
A
GI
I
Y
PII
R
NLPPL
YQ
S
Q
PNDSS
S
R
S
IG
S
Y
I
MWM
GI
V
A
D
CV
TS
A
I
F
L
TAMAPNLL
L
I
GL
M
KS
A
S
H
A
--
TL
SWG
D
WFL
GM
LP
L
S
I
L
L
V
L
L
V
PWL
A
YVLYPP
VL
K
SG
D
Q
V
P
R
WA
ET
EL
QA
MGPL
CS
REK
R
M
LGL
M
V
G
AL
V
LWIFG
GDY
--
IDA
A
M
VG
YS
VVALMLL
--
L
R
I
I
S
W
D
DIV
S
NK
A
AWN
VF
F
WLA
S
LI
T
LA
T
GL
N
NT
GFI
S
WF
G
KLLAG
S
L
S
G
Y
SP
TM
----
VMV
A
LI
V
VFY
LL
RYFFAS
A
T
AYT
S
A
LA
P
M
MI
A
A
A
LAM
P
---
E
I
PL
PVF
CL
M
V
GA
A
IG
L
G
S
I
LTPYATGP
S
PI
Y
YG
S
GY
LPTA
DYWRLGAIFG
L
I
-
FLVLL
V
I
T
G
fig|544404.4.peg.4099
Escherichia coli O157:H7 str. TW14359 (11-478/487)
LAPLAV
IA
II
A
LIP
V
PAGL
ESH
T
W
L
YFAVF
T
G
V
IVGLILEP
V
P
GA
VV
AM
VGI
S
I
IA
I
L
S
PW
LLF
SPEQ
LA
Q
P
G
F
KFT
A
KS
L
S
W
A
V
SGFS
N
S
V
I
WL
I
F
A
AF
M
F
GT
GYE
K
TGLGRRIAL
I
LVKKMG
H
RTL
F
LGYA
V
M
F
S
E
L
I
LAP
V
TPSN
S
AR
G
A
GI
I
Y
PII
R
NLPPL
YQ
S
Q
PNDSS
S
R
S
IG
S
Y
I
MWM
GI
V
A
D
CV
TS
A
I
F
L
TAMAPNLL
L
I
GL
M
KS
A
S
H
A
--
TL
SWG
D
WFL
GM
LP
L
S
I
L
L
V
L
L
V
PWL
A
YVLYPP
VL
K
SG
D
Q
V
P
R
WA
ET
EL
QA
MGPL
CS
REK
R
M
LGL
M
V
G
AL
V
LWIFG
GDY
--
IDA
A
M
VG
YS
VVALMLL
--
L
R
I
I
S
W
D
DIV
S
NK
A
AWN
VF
F
WLA
S
LI
T
LA
T
GL
N
NT
GFI
S
WF
G
KLLAG
S
L
S
G
Y
SP
TM
----
VMV
A
LI
V
VFY
LL
RYFFAS
A
T
AYT
S
A
LA
P
M
MI
A
A
A
LAM
P
---
E
I
PL
PVF
CL
M
V
GA
A
IG
L
G
S
I
LTPYATGP
S
PI
Y
YG
S
GY
LPTA
DYWRLGAIFG
L
I
-
FLVLL
V
I
T
G
fig|502346.5.peg.3312
Escherichia coli O157:H7 str. TW14588 (11-478/487)
LAPLAV
IA
II
A
LIP
V
PAGL
ESH
T
W
L
YFAVF
T
G
V
IVGLILEP
V
P
GA
VV
AM
VGI
S
I
IA
I
L
S
PW
LLF
SPEQ
LA
Q
P
G
F
KFT
A
KS
L
S
W
A
V
SGFS
N
S
V
I
WL
I
F
A
AF
M
F
GT
GYE
K
TGLGRRIAL
I
LVKKMG
H
RTL
F
LGYA
V
M
F
S
E
L
I
LAP
V
TPSN
S
AR
G
A
GI
I
Y
PII
R
NLPPL
YQ
S
Q
PNDSS
S
R
S
IG
S
Y
I
MWM
GI
V
A
D
CV
TS
A
I
F
L
TAMAPNLL
L
I
GL
M
KS
A
S
H
A
--
TL
SWG
D
WFL
GM
LP
L
S
I
L
L
V
L
L
V
PWL
A
YVLYPP
VL
K
SG
D
Q
V
P
R
WA
ET
EL
QA
MGPL
CS
REK
R
M
LGL
M
V
G
AL
V
LWIFG
GDY
--
IDA
A
M
VG
YS
VVALMLL
--
L
R
I
I
S
W
D
DIV
S
NK
A
AWN
VF
F
WLA
S
LI
T
LA
T
GL
N
NT
GFI
S
WF
G
KLLAG
S
L
S
G
Y
SP
TM
----
VMV
A
LI
V
VFY
LL
RYFFAS
A
T
AYT
S
A
LA
P
M
MI
A
A
A
LAM
P
---
E
I
PL
PVF
CL
M
V
GA
A
IG
L
G
S
I
LTPYATGP
S
PI
Y
YG
S
GY
LPTA
DYWRLGAIFG
L
I
-
FLVLL
V
I
T
G
fig|701177.3.peg.3801
Escherichia coli O55:H7 str. CB9615 (11-478/487)
LAPLAV
IA
II
A
LIP
V
PAGL
ESH
T
W
L
YFAVF
T
G
V
IVGLILEP
V
P
GA
VV
AM
VGI
S
I
IA
I
L
S
PW
LLF
SPEQ
LA
Q
P
G
F
KFT
A
KS
L
S
W
A
V
SGFS
N
S
V
I
WL
I
F
A
AF
M
F
GT
GYE
K
TGLGRRIAL
I
LVKKMG
H
RTL
F
LGYA
V
M
F
S
E
L
I
LAP
V
TPSN
S
AR
G
A
GI
I
Y
PII
R
NLPPL
YQ
S
Q
PNDSS
S
R
S
IG
S
Y
I
MWM
GI
V
A
D
CV
TS
A
I
F
L
TAMAPNLL
L
I
GL
M
KS
A
S
H
A
--
TL
SWG
D
WFL
GM
LP
L
S
I
L
L
V
L
L
V
PWL
A
YVLYPP
VL
K
SG
D
Q
V
P
R
WA
ET
EL
QA
MGPL
CS
REK
R
M
LGL
M
V
G
AL
V
LWIFG
GDY
--
IDA
A
M
VG
YS
VVALMLL
--
L
R
I
I
S
W
D
DIV
S
NK
A
AWN
VF
F
WLA
S
LI
T
LA
T
GL
N
NT
GFI
S
WF
G
KLLAG
S
L
S
G
Y
SP
TM
----
VMV
A
LI
V
VFY
LL
RYFFAS
A
T
AYT
S
A
LA
P
M
MI
A
A
A
LAM
P
---
E
I
PL
PVF
CL
M
V
GA
A
IG
L
G
S
I
LTPYATGP
S
PI
Y
YG
S
GY
LPTA
DYWRLGAIFG
L
I
-
FLVLL
V
I
T
G
fig|656440.3.peg.3298
Escherichia coli TA206 (11-478/487)
LAPLAV
IA
II
A
LIP
V
PAGL
ESH
T
W
L
YFAVF
T
G
V
IVGLILEP
V
P
GA
VV
AM
VGI
S
I
IA
I
L
S
PW
LLF
SPEQ
LA
Q
P
G
F
KFT
A
KS
L
S
W
A
V
SGFS
N
S
V
I
WL
I
F
A
AF
M
F
GT
GYE
K
TGLGRRIAL
I
LVKKMG
H
RTL
F
LGYA
V
M
F
S
E
L
I
LAP
V
TPSN
S
AR
G
A
GI
I
Y
PII
R
NLPPL
YQ
S
Q
PNDSS
S
R
S
IG
S
Y
I
MWM
GI
V
A
D
CV
TS
A
I
F
L
TAMAPNLL
L
I
GL
M
KS
A
S
H
A
--
TL
SWG
D
WFL
GM
LP
L
S
I
L
L
V
L
L
V
PWL
A
YVLYPP
VL
K
SG
D
Q
V
P
R
WA
ET
EL
QA
MGPL
CS
REK
R
M
LGL
M
V
G
AL
V
LWIFG
GDY
--
IDA
A
M
VG
YS
VVALMLL
--
L
R
I
I
S
W
D
DIV
S
NK
A
AWN
VF
F
WLA
S
LI
T
LA
T
GL
N
NT
GFI
S
WF
G
KLLAG
S
L
S
G
Y
SP
TI
----
VMV
A
LI
V
VFY
LL
RYFFAS
A
T
AYT
S
A
LA
P
M
MI
A
A
A
LAM
P
---
E
I
PL
PVF
CL
M
V
GA
A
IG
L
G
S
I
LTPYATGP
S
PI
Y
YG
S
GY
LPTA
DYWRLGAIFG
L
I
-
FLVLL
V
I
T
G
fig|413997.3.peg.3071
Escherichia coli B str. REL606 (11-478/487)
LAPLAV
IA
II
A
L
L
P
V
PAGL
ENH
T
W
L
YFAVF
T
G
V
IVGLILEP
V
P
GA
VV
AM
VGI
S
I
IA
I
L
S
PW
LLF
SPEQ
LA
Q
P
G
F
KFT
A
KS
L
S
W
A
V
SGFS
N
S
V
I
WL
I
F
A
AF
M
F
GT
GYE
K
TGLGRRIAL
I
LVKKMG
H
RTL
F
LGYA
V
M
F
S
E
L
I
LAP
V
TPSN
S
AR
G
A
GI
I
Y
PII
R
NLPPL
YQ
S
Q
PNDSS
S
R
S
IG
S
Y
I
MWM
GI
V
A
D
CV
TS
A
I
F
L
TAMAPNLL
L
I
GL
M
KS
A
S
H
A
--
TL
SWG
D
WFL
EM
LP
L
S
I
L
L
V
L
L
V
PWL
A
YVLYPP
VL
K
SG
D
Q
V
P
R
WA
ET
EL
QA
MGPL
CS
REK
R
M
LGL
M
V
G
AL
V
LWIFG
GDY
--
IDA
A
M
VG
YS
VVALMLL
--
L
R
I
I
S
W
D
DIV
S
NK
A
AWN
VF
F
WLA
S
LI
T
LA
T
GL
N
NT
GFI
S
WF
G
KLLAG
S
L
S
G
Y
SP
TM
----
VMV
A
LI
V
VFY
LL
RYFFAS
A
T
AYT
S
A
LA
P
M
MI
A
A
A
LAM
P
---
E
I
PL
PVF
CL
M
V
GA
A
IG
L
G
S
I
LTPYATGP
S
PI
Y
YG
S
GY
LPTA
DYWRLGAIFG
L
I
-
FLVLL
V
I
T
G
fig|511693.5.peg.3080
Escherichia coli BL21 (11-478/487)
LAPLAV
IA
II
A
L
L
P
V
PAGL
ENH
T
W
L
YFAVF
T
G
V
IVGLILEP
V
P
GA
VV
AM
VGI
S
I
IA
I
L
S
PW
LLF
SPEQ
LA
Q
P
G
F
KFT
A
KS
L
S
W
A
V
SGFS
N
S
V
I
WL
I
F
A
AF
M
F
GT
GYE
K
TGLGRRIAL
I
LVKKMG
H
RTL
F
LGYA
V
M
F
S
E
L
I
LAP
V
TPSN
S
AR
G
A
GI
I
Y
PII
R
NLPPL
YQ
S
Q
PNDSS
S
R
S
IG
S
Y
I
MWM
GI
V
A
D
CV
TS
A
I
F
L
TAMAPNLL
L
I
GL
M
KS
A
S
H
A
--
TL
SWG
D
WFL
EM
LP
L
S
I
L
L
V
L
L
V
PWL
A
YVLYPP
VL
K
SG
D
Q
V
P
R
WA
ET
EL
QA
MGPL
CS
REK
R
M
LGL
M
V
G
AL
V
LWIFG
GDY
--
IDA
A
M
VG
YS
VVALMLL
--
L
R
I
I
S
W
D
DIV
S
NK
A
AWN
VF
F
WLA
S
LI
T
LA
T
GL
N
NT
GFI
S
WF
G
KLLAG
S
L
S
G
Y
SP
TM
----
VMV
A
LI
V
VFY
LL
RYFFAS
A
T
AYT
S
A
LA
P
M
MI
A
A
A
LAM
P
---
E
I
PL
PVF
CL
M
V
GA
A
IG
L
G
S
I
LTPYATGP
S
PI
Y
YG
S
GY
LPTA
DYWRLGAIFG
L
I
-
FLVLL
V
I
T
G
fig|469008.4.peg.694
Escherichia coli BL21(DE3) (11-478/487)
LAPLAV
IA
II
A
L
L
P
V
PAGL
ENH
T
W
L
YFAVF
T
G
V
IVGLILEP
V
P
GA
VV
AM
VGI
S
I
IA
I
L
S
PW
LLF
SPEQ
LA
Q
P
G
F
KFT
A
KS
L
S
W
A
V
SGFS
N
S
V
I
WL
I
F
A
AF
M
F
GT
GYE
K
TGLGRRIAL
I
LVKKMG
H
RTL
F
LGYA
V
M
F
S
E
L
I
LAP
V
TPSN
S
AR
G
A
GI
I
Y
PII
R
NLPPL
YQ
S
Q
PNDSS
S
R
S
IG
S
Y
I
MWM
GI
V
A
D
CV
TS
A
I
F
L
TAMAPNLL
L
I
GL
M
KS
A
S
H
A
--
TL
SWG
D
WFL
EM
LP
L
S
I
L
L
V
L
L
V
PWL
A
YVLYPP
VL
K
SG
D
Q
V
P
R
WA
ET
EL
QA
MGPL
CS
REK
R
M
LGL
M
V
G
AL
V
LWIFG
GDY
--
IDA
A
M
VG
YS
VVALMLL
--
L
R
I
I
S
W
D
DIV
S
NK
A
AWN
VF
F
WLA
S
LI
T
LA
T
GL
N
NT
GFI
S
WF
G
KLLAG
S
L
S
G
Y
SP
TM
----
VMV
A
LI
V
VFY
LL
RYFFAS
A
T
AYT
S
A
LA
P
M
MI
A
A
A
LAM
P
---
E
I
PL
PVF
CL
M
V
GA
A
IG
L
G
S
I
LTPYATGP
S
PI
Y
YG
S
GY
LPTA
DYWRLGAIFG
L
I
-
FLVLL
V
I
T
G
fig|637912.3.peg.2201
Escherichia coli OP50 (11-478/487)
LAPLAV
IA
II
A
L
L
P
V
PAGL
ENH
T
W
L
YFAVF
T
G
V
IVGLILEP
V
P
GA
VV
AM
VGI
S
I
IA
I
L
S
PW
LLF
SPEQ
LA
Q
P
G
F
KFT
A
KS
L
S
W
A
V
SGFS
N
S
V
I
WL
I
F
A
AF
M
F
GT
GYE
K
TGLGRRIAL
I
LVKKMG
H
RTL
F
LGYA
V
M
F
S
E
L
I
LAP
V
TPSN
S
AR
G
A
GI
I
Y
PII
R
NLPPL
YQ
S
Q
PNDSS
S
R
S
IG
S
Y
I
MWM
GI
V
A
D
CV
TS
A
I
F
L
TAMAPNLL
L
I
GL
M
KS
A
S
H
A
--
TL
SWG
D
WFL
EM
LP
L
S
I
L
L
V
L
L
V
PWL
A
YVLYPP
VL
K
SG
D
Q
V
P
R
WA
ET
EL
QA
MGPL
CS
REK
R
M
LGL
M
V
G
AL
V
LWIFG
GDY
--
IDA
A
M
VG
YS
VVALMLL
--
L
R
I
I
S
W
D
DIV
S
NK
A
AWN
VF
F
WLA
S
LI
T
LA
T
GL
N
NT
GFI
S
WF
G
KLLAG
S
L
S
G
Y
SP
TM
----
VMV
A
LI
V
VFY
LL
RYFFAS
A
T
AYT
S
A
LA
P
M
MI
A
A
A
LAM
P
---
E
I
PL
PVF
CL
M
V
GA
A
IG
L
G
S
I
LTPYATGP
S
PI
Y
YG
S
GY
LPTA
DYWRLGAIFG
L
I
-
FLVLL
V
I
T
G
fig|340185.3.peg.426
Escherichia coli E22 (11-478/487)
LAPLAV
IA
II
A
LIP
V
PAGL
ESH
T
W
L
YFAVF
T
G
V
IVGLILEP
V
P
GA
VV
AM
VGI
S
I
IA
I
L
S
PW
LLF
SPEQ
LA
Q
P
G
F
KFT
A
KS
L
S
W
A
V
SGFS
N
S
V
I
WL
I
F
A
AF
M
F
GT
GYE
K
TGLGRRIAL
I
LVKKMG
H
RTL
F
LGYA
V
M
F
S
E
L
I
LAP
V
TPSN
S
AR
G
A
GI
I
Y
PII
R
NLPPL
YQ
S
Q
PNDSS
S
R
S
IG
S
Y
I
MWM
GI
V
A
D
CV
TS
A
I
F
L
TAMAPNLL
L
I
GL
M
KS
A
S
H
A
--
TL
SWG
D
WFL
GM
LP
L
S
I
L
L
V
L
L
V
PWL
A
YVLYPP
VL
K
SG
D
Q
V
P
R
WA
ET
EL
QA
MGPL
CS
REK
R
M
LGL
M
V
G
AL
V
LWIFG
GDY
--
IDA
A
M
VG
YS
VVALMLL
--
L
R
I
I
S
W
D
DIV
S
NK
A
AWN
VF
F
WLA
S
LI
T
LA
T
GL
N
NT
GFI
S
WF
G
KLLAG
S
L
S
G
Y
SP
TM
----
VMV
A
LI
V
VFY
LL
RYFFAS
A
T
AYT
S
A
LA
P
M
MI
A
A
A
LAM
P
---
E
I
PL
PVF
CL
M
V
GA
A
IG
L
G
S
I
LTPYATGP
S
PI
Y
YG
S
GY
LPTV
DYWRLGAIFG
L
I
-
FLVLL
V
I
T
G
fig|340185.4.peg.467
Escherichia coli E22 (11-478/487)
LAPLAV
IA
II
A
LIP
V
PAGL
ESH
T
W
L
YFAVF
T
G
V
IVGLILEP
V
P
GA
VV
AM
VGI
S
I
IA
I
L
S
PW
LLF
SPEQ
LA
Q
P
G
F
KFT
A
KS
L
S
W
A
V
SGFS
N
S
V
I
WL
I
F
A
AF
M
F
GT
GYE
K
TGLGRRIAL
I
LVKKMG
H
RTL
F
LGYA
V
M
F
S
E
L
I
LAP
V
TPSN
S
AR
G
A
GI
I
Y
PII
R
NLPPL
YQ
S
Q
PNDSS
S
R
S
IG
S
Y
I
MWM
GI
V
A
D
CV
TS
A
I
F
L
TAMAPNLL
L
I
GL
M
KS
A
S
H
A
--
TL
SWG
D
WFL
GM
LP
L
S
I
L
L
V
L
L
V
PWL
A
YVLYPP
VL
K
SG
D
Q
V
P
R
WA
ET
EL
QA
MGPL
CS
REK
R
M
LGL
M
V
G
AL
V
LWIFG
GDY
--
IDA
A
M
VG
YS
VVALMLL
--
L
R
I
I
S
W
D
DIV
S
NK
A
AWN
VF
F
WLA
S
LI
T
LA
T
GL
N
NT
GFI
S
WF
G
KLLAG
S
L
S
G
Y
SP
TM
----
VMV
A
LI
V
VFY
LL
RYFFAS
A
T
AYT
S
A
LA
P
M
MI
A
A
A
LAM
P
---
E
I
PL
PVF
CL
M
V
GA
A
IG
L
G
S
I
LTPYATGP
S
PI
Y
YG
S
GY
LPTV
DYWRLGAIFG
L
I
-
FLVLL
V
I
T
G
fig|331111.12.peg.3799
Escherichia coli E24377A (11-478/487)
LAPLAV
IA
II
A
LIP
V
PAGL
ESH
T
W
L
YFAVF
T
G
V
IVGLILEP
V
P
GA
VV
AM
VGI
S
I
IA
I
L
S
PW
LLF
SPEQ
LA
Q
P
G
F
KFT
A
KS
L
S
W
A
V
SGFS
N
S
V
I
WL
I
F
A
AF
M
F
GT
GYE
K
TGLGRRIAL
I
LVKKMG
H
RTL
F
LGYA
V
M
F
S
E
L
I
LAP
V
TPSN
S
AR
G
A
GI
I
Y
PII
R
NLPPL
YQ
S
Q
PNDSS
S
R
S
IG
S
Y
I
MWM
GI
V
A
D
CV
TS
A
I
F
L
TAMAPNLL
L
I
GL
M
KS
A
S
H
A
--
TL
SWG
D
WFL
GM
LP
L
S
I
L
L
V
L
L
V
PWL
A
YVLYPP
VL
K
SG
D
Q
V
P
R
WA
ET
EL
QA
MGPL
CS
REK
R
M
LGL
M
V
G
AL
V
LWIFG
GDY
--
IDA
A
M
VG
YS
VVALMLL
--
L
R
I
I
S
W
D
DIV
S
NK
A
AWN
VF
F
WLA
S
LI
T
LA
T
GL
N
NT
GFI
S
WF
G
KLLAG
S
L
S
G
Y
SP
TM
----
VMV
A
LI
V
VFY
LL
RYFFAS
A
T
AYT
S
A
LA
P
M
MI
A
A
A
LAM
P
---
E
I
PL
PVF
CL
M
V
GA
A
IG
L
G
S
I
LTPYATGP
S
PI
Y
YG
S
GY
LPTV
DYWRLGAIFG
L
I
-
FLVLL
V
I
T
G
fig|331111.3.peg.1215
Escherichia coli E24377A (11-478/487)
LAPLAV
IA
II
A
LIP
V
PAGL
ESH
T
W
L
YFAVF
T
G
V
IVGLILEP
V
P
GA
VV
AM
VGI
S
I
IA
I
L
S
PW
LLF
SPEQ
LA
Q
P
G
F
KFT
A
KS
L
S
W
A
V
SGFS
N
S
V
I
WL
I
F
A
AF
M
F
GT
GYE
K
TGLGRRIAL
I
LVKKMG
H
RTL
F
LGYA
V
M
F
S
E
L
I
LAP
V
TPSN
S
AR
G
A
GI
I
Y
PII
R
NLPPL
YQ
S
Q
PNDSS
S
R
S
IG
S
Y
I
MWM
GI
V
A
D
CV
TS
A
I
F
L
TAMAPNLL
L
I
GL
M
KS
A
S
H
A
--
TL
SWG
D
WFL
GM
LP
L
S
I
L
L
V
L
L
V
PWL
A
YVLYPP
VL
K
SG
D
Q
V
P
R
WA
ET
EL
QA
MGPL
CS
REK
R
M
LGL
M
V
G
AL
V
LWIFG
GDY
--
IDA
A
M
VG
YS
VVALMLL
--
L
R
I
I
S
W
D
DIV
S
NK
A
AWN
VF
F
WLA
S
LI
T
LA
T
GL
N
NT
GFI
S
WF
G
KLLAG
S
L
S
G
Y
SP
TM
----
VMV
A
LI
V
VFY
LL
RYFFAS
A
T
AYT
S
A
LA
P
M
MI
A
A
A
LAM
P
---
E
I
PL
PVF
CL
M
V
GA
A
IG
L
G
S
I
LTPYATGP
S
PI
Y
YG
S
GY
LPTV
DYWRLGAIFG
L
I
-
FLVLL
V
I
T
G
fig|595495.4.peg.868
Escherichia coli KO11 (11-478/487)
LAPLAV
IA
II
A
LIP
V
PAGL
ESH
T
W
L
YFAVF
T
G
V
IVGLILEP
V
P
GA
VV
AM
VGI
S
I
IA
I
L
S
PW
LLF
SPEQ
LA
Q
P
G
F
KFT
A
KS
L
S
W
A
V
SGFS
N
S
V
I
WL
I
F
A
AF
M
F
GT
GYE
K
TGLGRRIAL
I
LVKKMG
H
RTL
F
LGYA
V
M
F
S
E
L
I
LAP
V
TPSN
S
AR
G
A
GI
I
Y
PII
R
NLPPL
YQ
S
Q
PNDSS
S
R
S
IG
S
Y
I
MWM
GI
V
A
D
CV
TS
A
I
F
L
TAMAPNLL
L
I
GL
M
KS
A
S
H
A
--
TL
SWG
D
WFL
GM
LP
L
S
I
L
L
V
L
L
V
PWL
A
YVLYPP
VL
K
SG
D
Q
V
P
R
WA
ET
EL
QA
MGPL
CS
REK
R
M
LGL
M
V
G
AL
V
LWIFG
GDY
--
IDA
A
M
VG
YS
VVALMLL
--
L
R
I
I
S
W
D
DIV
S
NK
A
AWN
VF
F
WLA
S
LI
T
LA
T
GL
N
NT
GFI
S
WF
G
KLLAG
S
L
S
G
Y
SP
TM
----
VMV
A
LI
V
VFY
LL
RYFFAS
A
T
AYT
S
A
LA
P
M
MI
A
A
A
LAM
P
---
E
I
PL
PVF
CL
M
V
GA
A
IG
L
G
S
I
LTPYATGP
S
PI
Y
YG
S
GY
LPTV
DYWRLGAIFG
L
I
-
FLVLL
V
I
T
G
fig|585395.4.peg.3909
Escherichia coli O103:H2 str. 12009 (11-478/487)
LAPLAV
IA
II
A
LIP
V
PAGL
ESH
T
W
L
YFAVF
T
G
V
IVGLILEP
V
P
GA
VV
AM
VGI
S
I
IA
I
L
S
PW
LLF
SPEQ
LA
Q
P
G
F
KFT
A
KS
L
S
W
A
V
SGFS
N
S
V
I
WL
I
F
A
AF
M
F
GT
GYE
K
TGLGRRIAL
I
LVKKMG
H
RTL
F
LGYA
V
M
F
S
E
L
I
LAP
V
TPSN
S
AR
G
A
GI
I
Y
PII
R
NLPPL
YQ
S
Q
PNDSS
S
R
S
IG
S
Y
I
MWM
GI
V
A
D
CV
TS
A
I
F
L
TAMAPNLL
L
I
GL
M
KS
A
S
H
A
--
TL
SWG
D
WFL
GM
LP
L
S
I
L
L
V
L
L
V
PWL
A
YVLYPP
VL
K
SG
D
Q
V
P
R
WA
ET
EL
QA
MGPL
CS
REK
R
M
LGL
M
V
G
AL
V
LWIFG
GDY
--
IDA
A
M
VG
YS
VVALMLL
--
L
R
I
I
S
W
D
DIV
S
NK
A
AWN
VF
F
WLA
S
LI
T
LA
T
GL
N
NT
GFI
S
WF
G
KLLAG
S
L
S
G
Y
SP
TM
----
VMV
A
LI
V
VFY
LL
RYFFAS
A
T
AYT
S
A
LA
P
M
MI
A
A
A
LAM
P
---
E
I
PL
PVF
CL
M
V
GA
A
IG
L
G
S
I
LTPYATGP
S
PI
Y
YG
S
GY
LPTV
DYWRLGAIFG
L
I
-
FLVLL
V
I
T
G
fig|566546.3.peg.542
Escherichia coli W (11-478/487)
LAPLAV
IA
II
A
LIP
V
PAGL
ESH
T
W
L
YFAVF
T
G
V
IVGLILEP
V
P
GA
VV
AM
VGI
S
I
IA
I
L
S
PW
LLF
SPEQ
LA
Q
P
G
F
KFT
A
KS
L
S
W
A
V
SGFS
N
S
V
I
WL
I
F
A
AF
M
F
GT
GYE
K
TGLGRRIAL
I
LVKKMG
H
RTL
F
LGYA
V
M
F
S
E
L
I
LAP
V
TPSN
S
AR
G
A
GI
I
Y
PII
R
NLPPL
YQ
S
Q
PNDSS
S
R
S
IG
S
Y
I
MWM
GI
V
A
D
CV
TS
A
I
F
L
TAMAPNLL
L
I
GL
M
KS
A
S
H
A
--
TL
SWG
D
WFL
GM
LP
L
S
I
L
L
V
L
L
V
PWL
A
YVLYPP
VL
K
SG
D
Q
V
P
R
WA
ET
EL
QA
MGPL
CS
REK
R
M
LGL
M
V
G
AL
V
LWIFG
GDY
--
IDA
A
M
VG
YS
VVALMLL
--
L
R
I
I
S
W
D
DIV
S
NK
A
AWN
VF
F
WLA
S
LI
T
LA
T
GL
N
NT
GFI
S
WF
G
KLLAG
S
L
S
G
Y
SP
TM
----
VMV
A
LI
V
VFY
LL
RYFFAS
A
T
AYT
S
A
LA
P
M
MI
A
A
A
LAM
P
---
E
I
PL
PVF
CL
M
V
GA
A
IG
L
G
S
I
LTPYATGP
S
PI
Y
YG
S
GY
LPTV
DYWRLGAIFG
L
I
-
FLVLL
V
I
T
G
fig|566546.4.peg.3293
Escherichia coli W (11-478/487)
LAPLAV
IA
II
A
LIP
V
PAGL
ESH
T
W
L
YFAVF
T
G
V
IVGLILEP
V
P
GA
VV
AM
VGI
S
I
IA
I
L
S
PW
LLF
SPEQ
LA
Q
P
G
F
KFT
A
KS
L
S
W
A
V
SGFS
N
S
V
I
WL
I
F
A
AF
M
F
GT
GYE
K
TGLGRRIAL
I
LVKKMG
H
RTL
F
LGYA
V
M
F
S
E
L
I
LAP
V
TPSN
S
AR
G
A
GI
I
Y
PII
R
NLPPL
YQ
S
Q
PNDSS
S
R
S
IG
S
Y
I
MWM
GI
V
A
D
CV
TS
A
I
F
L
TAMAPNLL
L
I
GL
M
KS
A
S
H
A
--
TL
SWG
D
WFL
GM
LP
L
S
I
L
L
V
L
L
V
PWL
A
YVLYPP
VL
K
SG
D
Q
V
P
R
WA
ET
EL
QA
MGPL
CS
REK
R
M
LGL
M
V
G
AL
V
LWIFG
GDY
--
IDA
A
M
VG
YS
VVALMLL
--
L
R
I
I
S
W
D
DIV
S
NK
A
AWN
VF
F
WLA
S
LI
T
LA
T
GL
N
NT
GFI
S
WF
G
KLLAG
S
L
S
G
Y
SP
TM
----
VMV
A
LI
V
VFY
LL
RYFFAS
A
T
AYT
S
A
LA
P
M
MI
A
A
A
LAM
P
---
E
I
PL
PVF
CL
M
V
GA
A
IG
L
G
S
I
LTPYATGP
S
PI
Y
YG
S
GY
LPTV
DYWRLGAIFG
L
I
-
FLVLL
V
I
T
G
fig|670897.3.peg.4256
Escherichia coli 2362-75 (11-478/487)
LAPLAV
IA
II
A
L
L
P
V
PAGL
ESH
T
W
L
YFAVF
T
G
V
IVGLILEP
V
P
GA
VV
AM
VGI
S
I
IA
I
L
S
PW
LLF
SPEQ
LA
Q
P
G
F
KFT
A
KS
L
S
W
A
V
SGFS
N
S
V
I
WL
I
F
A
AF
M
F
GT
GYE
K
TGLGRRIAL
I
LVKKMG
H
RTL
F
LGYA
V
M
F
S
E
L
I
LAP
V
TPSN
S
AR
G
A
GI
I
Y
PII
R
NLPPL
YQ
S
Q
PNDSS
S
R
S
IG
S
Y
I
MWM
GI
V
A
D
CV
TS
A
I
F
L
TAMAPNLL
L
I
GL
M
KS
A
S
N
A
--
TL
SWG
D
WFL
GM
LP
L
S
I
L
L
V
L
L
V
PWL
A
YVLYPP
VL
K
SG
D
Q
V
P
R
WA
ET
EL
QA
MGPL
CS
REK
R
M
LGL
M
V
G
AL
V
LWIFG
GDY
--
IDA
A
M
VG
YS
VVALMLL
--
L
R
I
I
C
W
D
DIV
S
NK
A
AWN
VF
F
WLA
S
LI
T
LA
T
GL
N
NT
GFI
S
WF
G
KLLAG
S
L
S
G
Y
SP
TI
----
VMV
A
LI
V
VFY
LL
RYFFAS
A
T
AYT
S
A
LA
P
M
MI
A
A
A
LAM
P
---
E
I
PL
PVF
CL
M
V
GA
A
IG
L
G
S
I
LTPYATGP
S
PI
Y
YG
S
GY
LPTA
DYWRLGAIFG
L
I
-
FLVLL
V
I
T
G
fig|216593.1.peg.5077
Escherichia coli E2348/69 (11-478/487)
LAPLAV
IA
II
A
L
L
P
V
PAGL
ESH
T
W
L
YFAVF
T
G
V
IVGLILEP
V
P
GA
VV
AM
VGI
S
I
IA
I
L
S
PW
LLF
SPEQ
LA
Q
P
G
F
KFT
A
KS
L
S
W
A
V
SGFS
N
S
V
I
WL
I
F
A
AF
M
F
GT
GYE
K
TGLGRRIAL
I
LVKKMG
H
RTL
F
LGYA
V
M
F
S
E
L
I
LAP
V
TPSN
S
AR
G
A
GI
I
Y
PII
R
NLPPL
YQ
S
Q
PNDSS
S
R
S
IG
S
Y
I
MWM
GI
V
A
D
CV
TS
A
I
F
L
TAMAPNLL
L
I
GL
M
KS
A
S
N
A
--
TL
SWG
D
WFL
GM
LP
L
S
I
L
L
V
L
L
V
PWL
A
YVLYPP
VL
K
SG
D
Q
V
P
R
WA
ET
EL
QA
MGPL
CS
REK
R
M
LGL
M
V
G
AL
V
LWIFG
GDY
--
IDA
A
M
VG
YS
VVALMLL
--
L
R
I
I
C
W
D
DIV
S
NK
A
AWN
VF
F
WLA
S
LI
T
LA
T
GL
N
NT
GFI
S
WF
G
KLLAG
S
L
S
G
Y
SP
TI
----
VMV
A
LI
V
VFY
LL
RYFFAS
A
T
AYT
S
A
LA
P
M
MI
A
A
A
LAM
P
---
E
I
PL
PVF
CL
M
V
GA
A
IG
L
G
S
I
LTPYATGP
S
PI
Y
YG
S
GY
LPTA
DYWRLGAIFG
L
I
-
FLVLL
V
I
T
G
fig|574521.7.peg.3421
Escherichia coli O127:H6 str. E2348/69 (11-478/487)
LAPLAV
IA
II
A
L
L
P
V
PAGL
ESH
T
W
L
YFAVF
T
G
V
IVGLILEP
V
P
GA
VV
AM
VGI
S
I
IA
I
L
S
PW
LLF
SPEQ
LA
Q
P
G
F
KFT
A
KS
L
S
W
A
V
SGFS
N
S
V
I
WL
I
F
A
AF
M
F
GT
GYE
K
TGLGRRIAL
I
LVKKMG
H
RTL
F
LGYA
V
M
F
S
E
L
I
LAP
V
TPSN
S
AR
G
A
GI
I
Y
PII
R
NLPPL
YQ
S
Q
PNDSS
S
R
S
IG
S
Y
I
MWM
GI
V
A
D
CV
TS
A
I
F
L
TAMAPNLL
L
I
GL
M
KS
A
S
N
A
--
TL
SWG
D
WFL
GM
LP
L
S
I
L
L
V
L
L
V
PWL
A
YVLYPP
VL
K
SG
D
Q
V
P
R
WA
ET
EL
QA
MGPL
CS
REK
R
M
LGL
M
V
G
AL
V
LWIFG
GDY
--
IDA
A
M
VG
YS
VVALMLL
--
L
R
I
I
C
W
D
DIV
S
NK
A
AWN
VF
F
WLA
S
LI
T
LA
T
GL
N
NT
GFI
S
WF
G
KLLAG
S
L
S
G
Y
SP
TI
----
VMV
A
LI
V
VFY
LL
RYFFAS
A
T
AYT
S
A
LA
P
M
MI
A
A
A
LAM
P
---
E
I
PL
PVF
CL
M
V
GA
A
IG
L
G
S
I
LTPYATGP
S
PI
Y
YG
S
GY
LPTA
DYWRLGAIFG
L
I
-
FLVLL
V
I
T
G
fig|362663.8.peg.3183
Escherichia coli 536 (11-478/487)
LAPLAV
IA
II
A
LIP
V
PAGL
ESH
T
W
L
YFAVF
T
G
V
IVGLILEP
V
P
GA
VV
AM
VGI
S
I
IA
I
L
S
PW
LLF
SPEQ
LA
Q
P
G
F
KFT
A
KS
L
S
W
A
V
SGFS
N
S
V
I
WL
I
F
A
AF
M
F
GT
GYE
K
TGLGRRIAL
I
LVKKMG
H
RTL
F
LGYA
V
M
F
S
E
L
I
LAP
V
TPSN
S
AR
G
A
GI
I
Y
PII
R
NLPPL
YQ
S
Q
PNDSS
S
R
S
IG
S
Y
I
MWM
GI
V
A
D
CV
TS
A
I
F
L
TAMAPNLL
L
I
GL
M
KS
A
S
H
A
--
TL
SWG
D
WFL
GM
LP
L
S
I
L
L
V
L
L
V
PWL
A
YVLYPP
VL
K
SG
D
Q
V
P
R
WA
ET
EL
QA
MGPL
CS
REK
R
M
LGL
M
V
G
AL
V
LWIFG
GDY
--
IDA
A
M
VG
YS
VVALMLL
--
L
R
I
I
S
W
D
DIV
S
NK
A
AWN
VF
F
WLA
S
LI
T
LA
T
GL
N
NT
GFI
S
WF
G
KLLAG
S
L
S
G
Y
SP
TI
----
VMV
A
LI
V
VFY
LL
RYFFAS
A
T
AYT
S
A
LA
P
M
MI
A
A
A
LAM
P
---
E
I
PL
PVF
CL
M
V
GA
A
IG
L
G
S
I
LTPYATGP
S
PI
Y
YG
S
GY
LPTV
DYWRLGAIFG
L
I
-
FLVLL
V
I
T
G
fig|362663.9.peg.3194
Escherichia coli 536 (11-478/487)
LAPLAV
IA
II
A
LIP
V
PAGL
ESH
T
W
L
YFAVF
T
G
V
IVGLILEP
V
P
GA
VV
AM
VGI
S
I
IA
I
L
S
PW
LLF
SPEQ
LA
Q
P
G
F
KFT
A
KS
L
S
W
A
V
SGFS
N
S
V
I
WL
I
F
A
AF
M
F
GT
GYE
K
TGLGRRIAL
I
LVKKMG
H
RTL
F
LGYA
V
M
F
S
E
L
I
LAP
V
TPSN
S
AR
G
A
GI
I
Y
PII
R
NLPPL
YQ
S
Q
PNDSS
S
R
S
IG
S
Y
I
MWM
GI
V
A
D
CV
TS
A
I
F
L
TAMAPNLL
L
I
GL
M
KS
A
S
H
A
--
TL
SWG
D
WFL
GM
LP
L
S
I
L
L
V
L
L
V
PWL
A
YVLYPP
VL
K
SG
D
Q
V
P
R
WA
ET
EL
QA
MGPL
CS
REK
R
M
LGL
M
V
G
AL
V
LWIFG
GDY
--
IDA
A
M
VG
YS
VVALMLL
--
L
R
I
I
S
W
D
DIV
S
NK
A
AWN
VF
F
WLA
S
LI
T
LA
T
GL
N
NT
GFI
S
WF
G
KLLAG
S
L
S
G
Y
SP
TI
----
VMV
A
LI
V
VFY
LL
RYFFAS
A
T
AYT
S
A
LA
P
M
MI
A
A
A
LAM
P
---
E
I
PL
PVF
CL
M
V
GA
A
IG
L
G
S
I
LTPYATGP
S
PI
Y
YG
S
GY
LPTV
DYWRLGAIFG
L
I
-
FLVLL
V
I
T
G
fig|656393.3.peg.4116
Escherichia coli H299 (11-478/487)
LAPLAV
IA
II
A
LIP
V
PAGL
ESH
T
W
L
YFAVF
T
G
V
IVGLILEP
V
P
GA
VV
AM
VGI
S
I
IA
I
L
S
PW
LLF
SPEQ
LA
Q
P
G
F
KFT
A
KS
L
S
W
A
V
SGFS
N
S
V
I
WL
I
F
A
AF
M
F
GT
GYE
K
TGLGRRIAL
I
LVKKMG
H
RTL
F
LGYA
V
M
F
S
E
L
I
LAP
V
TPSN
S
AR
G
A
GI
I
Y
PII
R
NLPPL
YQ
S
Q
PNDSS
S
R
S
IG
S
Y
I
MWM
GI
V
A
D
CV
TS
A
I
F
L
TAMAPNLL
L
I
GL
M
KS
A
S
H
A
--
TL
SWG
D
WFL
GM
LP
L
S
I
L
L
V
L
L
V
PWL
A
YVLYPP
VL
K
SG
D
Q
V
P
R
WA
ET
EL
QA
MGPL
CS
REK
R
M
LGL
M
V
G
AL
V
LWIFG
GDY
--
IDA
A
M
VG
YS
VVALMLL
--
L
R
I
I
S
W
D
DIV
S
NK
A
AWN
VF
F
WLA
S
LI
T
LA
T
GL
N
NT
GFI
S
WF
G
KLLAG
S
L
S
G
Y
SP
TI
----
VMV
A
LI
V
VFY
LL
RYFFAS
A
T
AYT
S
A
LA
P
M
MI
A
A
A
LAM
P
---
E
I
PL
PVF
CL
M
V
GA
A
IG
L
G
S
I
LTPYATGP
S
PI
Y
YG
S
GY
LPTV
DYWRLGAIFG
L
I
-
FLVLL
V
I
T
G
fig|749527.3.peg.2243
Escherichia coli MS 21-1 (11-478/487)
LAPLAV
IA
II
A
LIP
V
PAGL
ESH
T
W
L
YFAVF
T
G
V
IVGLILEP
V
P
GA
VV
AM
VGI
S
I
IA
I
L
S
PW
LLF
SPEQ
LA
Q
P
G
F
KFT
A
KS
L
S
W
A
V
SGFS
N
S
V
I
WL
I
F
A
AF
M
F
GT
GYE
K
TGLGRRIAL
I
LVKKMG
H
RTL
F
LGYA
V
M
F
S
E
L
I
LAP
V
TPSN
S
AR
G
A
GI
I
Y
PII
R
NLPPL
YQ
S
Q
PNDSS
S
R
S
IG
S
Y
I
MWM
GI
V
A
D
CV
TS
A
I
F
L
TAMAPNLL
L
I
GL
M
KS
A
S
H
A
--
TL
SWG
D
WFL
GM
LP
L
S
I
L
L
V
L
L
V
PWL
A
YVLYPP
VL
K
SG
D
Q
V
P
R
WA
ET
EL
QA
MGPL
CS
REK
R
M
LGL
M
V
G
AL
V
LWIFG
GDY
--
IDA
A
M
VG
YS
VVALMLL
--
L
R
I
I
S
W
D
DIV
S
NK
A
AWN
VF
F
WLA
S
LI
T
LA
T
GL
N
NT
GFI
S
WF
G
KLLAG
S
L
S
G
Y
SP
TI
----
VMV
A
LI
V
VFY
LL
RYFFAS
A
T
AYT
S
A
LA
P
M
MI
A
A
A
LAM
P
---
E
I
PL
PVF
CL
M
V
GA
A
IG
L
G
S
I
LTPYATGP
S
PI
Y
YG
S
GY
LPTV
DYWRLGAIFG
L
I
-
FLVLL
V
I
T
G
fig|439855.10.peg.3515
Escherichia coli SMS-3-5 (11-478/487)
LAPLAV
IA
II
A
LIP
V
PAGL
ESH
T
W
L
YFAVF
T
G
V
IVGLILEP
V
P
GA
VV
AM
VGI
S
I
IA
I
L
S
PW
LLF
SPEQ
LA
Q
P
G
F
KFT
A
KS
L
S
W
A
V
SGFS
N
S
V
I
WL
I
F
A
AF
M
F
GT
GYE
K
TGLGRRIAL
I
LVKKMG
H
RTL
F
LGYA
V
M
F
S
E
L
I
LAP
V
TPSN
S
AR
G
A
GI
I
Y
PII
R
NLPPL
YQ
S
Q
PNDSS
S
R
S
IG
S
Y
I
MWM
GI
V
A
D
CV
TS
A
I
F
L
TAMAPNLL
L
I
GL
M
KS
A
S
H
A
--
TL
SWG
D
WFL
GM
LP
L
S
I
L
L
V
L
L
V
PWL
A
YVLYPP
VL
K
SG
D
Q
V
P
R
WA
ET
EL
QA
MGPL
CS
REK
R
M
LGL
M
V
G
AL
V
LWIFG
GDY
--
IDA
A
M
VG
YS
VVALMLL
--
L
R
I
I
S
W
D
DIV
S
NK
A
AWN
VF
F
WLA
S
LI
T
LA
T
GL
N
NT
GFI
S
WF
G
KLLAG
S
L
S
G
Y
SP
TI
----
VMV
A
LI
V
VFY
LL
RYFFAS
A
T
AYT
S
A
LA
P
M
MI
A
A
A
LAM
P
---
E
I
PL
PVF
CL
M
V
GA
A
IG
L
G
S
I
LTPYATGP
S
PI
Y
YG
S
GY
LPTV
DYWRLGAIFG
L
I
-
FLVLL
V
I
T
G
fig|670888.3.peg.3191
Escherichia coli 1827-70 (11-478/487)
LAPLAV
IA
II
A
LIP
V
PAGL
ESH
T
W
L
YFAVF
T
G
V
IVGLILEP
V
P
GA
VV
AM
VGI
S
I
IA
I
L
S
PW
LLF
SPEQ
LA
Q
P
G
F
KFT
A
KS
L
S
W
A
V
SGFS
N
S
V
I
WL
I
F
A
AF
M
F
GT
GYE
K
TGLGRRIAL
I
LVKKMG
H
RTL
F
LGYA
V
M
F
S
E
L
I
LAP
V
TPSN
S
AR
G
A
GI
I
Y
PII
R
NLPPL
YQ
S
Q
PNDSS
S
R
S
IG
S
Y
I
MWM
GI
V
A
D
CV
TS
A
I
F
L
TAMAPNLL
L
I
GL
M
KS
A
S
H
A
--
TL
SWG
D
WFL
GM
LP
L
S
I
L
L
V
L
L
V
PW
M
A
YVLYPP
VL
K
SG
D
Q
V
P
R
WA
ET
EL
QA
MGPL
CS
REK
R
M
LGL
M
V
G
AL
V
LWIFG
GDY
--
IDA
A
M
VG
YS
VVALMLL
--
L
R
I
I
C
W
D
DIV
S
NK
A
AWN
VF
F
WLA
S
LI
T
LA
T
GL
N
NT
GFI
S
WF
G
KLLAG
S
L
S
G
Y
SP
TM
----
VMV
A
LI
V
VFY
LL
RYFFAS
A
T
AYT
S
A
LA
P
M
MI
A
A
A
LAM
P
---
E
I
PL
PVF
CL
M
V
GA
A
IG
L
G
S
I
LTPYATGP
S
PI
Y
YG
S
GY
LPTA
DYWRLGAIFG
L
I
-
FLVLL
V
I
T
G
fig|331112.3.peg.3033
Escherichia coli HS (11-478/487)
LAPLAV
IA
II
A
LIP
V
PAGL
ESH
T
W
L
YFAVF
T
G
V
IVGLILEP
V
P
GA
VV
AM
VGI
S
I
IA
I
L
S
PW
LLF
SPEQ
LA
Q
P
G
F
KFT
A
KS
L
S
W
A
V
SGFS
N
S
V
I
WL
I
F
A
AF
M
F
GT
GYE
K
TGLGRRIAL
I
LVKKMG
H
RTL
F
LGYA
V
M
F
S
E
L
I
LAP
V
TPSN
S
AR
G
A
GI
I
Y
PII
R
NLPPL
YQ
S
Q
PNDSS
S
R
S
IG
S
Y
I
MWM
GI
V
A
D
CV
TS
A
I
F
L
TAMAPNLL
L
I
GL
M
KS
A
S
H
A
--
TL
SWG
D
WFL
GM
LP
L
S
I
L
L
V
L
L
V
PW
M
A
YVLYPP
VL
K
SG
D
Q
V
P
R
WA
ET
EL
QA
MGPL
CS
REK
R
M
LGL
M
V
G
AL
V
LWIFG
GDY
--
IDA
A
M
VG
YS
VVALMLL
--
L
R
I
I
C
W
D
DIV
S
NK
A
AWN
VF
F
WLA
S
LI
T
LA
T
GL
N
NT
GFI
S
WF
G
KLLAG
S
L
S
G
Y
SP
TM
----
VMV
A
LI
V
VFY
LL
RYFFAS
A
T
AYT
S
A
LA
P
M
MI
A
A
A
LAM
P
---
E
I
PL
PVF
CL
M
V
GA
A
IG
L
G
S
I
LTPYATGP
S
PI
Y
YG
S
GY
LPTA
DYWRLGAIFG
L
I
-
FLVLL
V
I
T
G
fig|331112.6.peg.3168
Escherichia coli HS (11-478/487)
LAPLAV
IA
II
A
LIP
V
PAGL
ESH
T
W
L
YFAVF
T
G
V
IVGLILEP
V
P
GA
VV
AM
VGI
S
I
IA
I
L
S
PW
LLF
SPEQ
LA
Q
P
G
F
KFT
A
KS
L
S
W
A
V
SGFS
N
S
V
I
WL
I
F
A
AF
M
F
GT
GYE
K
TGLGRRIAL
I
LVKKMG
H
RTL
F
LGYA
V
M
F
S
E
L
I
LAP
V
TPSN
S
AR
G
A
GI
I
Y
PII
R
NLPPL
YQ
S
Q
PNDSS
S
R
S
IG
S
Y
I
MWM
GI
V
A
D
CV
TS
A
I
F
L
TAMAPNLL
L
I
GL
M
KS
A
S
H
A
--
TL
SWG
D
WFL
GM
LP
L
S
I
L
L
V
L
L
V
PW
M
A
YVLYPP
VL
K
SG
D
Q
V
P
R
WA
ET
EL
QA
MGPL
CS
REK
R
M
LGL
M
V
G
AL
V
LWIFG
GDY
--
IDA
A
M
VG
YS
VVALMLL
--
L
R
I
I
C
W
D
DIV
S
NK
A
AWN
VF
F
WLA
S
LI
T
LA
T
GL
N
NT
GFI
S
WF
G
KLLAG
S
L
S
G
Y
SP
TM
----
VMV
A
LI
V
VFY
LL
RYFFAS
A
T
AYT
S
A
LA
P
M
MI
A
A
A
LAM
P
---
E
I
PL
PVF
CL
M
V
GA
A
IG
L
G
S
I
LTPYATGP
S
PI
Y
YG
S
GY
LPTA
DYWRLGAIFG
L
I
-
FLVLL
V
I
T
G
fig|585057.4.peg.3679
Escherichia coli IAI39 (11-478/487)
LAPLAV
IA
II
A
LIP
V
PAGL
ESH
T
W
L
YFAVF
T
G
V
IVGLILEP
V
P
GA
VV
AM
VGI
S
I
IA
I
L
S
PW
LLF
SPEQ
LA
Q
P
G
F
KFT
A
KS
L
S
W
A
V
SGFS
N
S
V
I
WL
I
F
A
AF
M
F
GT
GYE
K
TGLGRRIAL
I
LVKKMG
H
RTL
F
LGYA
V
M
F
S
E
L
I
LAP
V
TPSN
S
AR
G
A
GI
I
Y
PII
R
NLPPL
YQ
S
Q
PNDSS
S
R
S
IG
S
Y
I
MWM
GI
V
A
D
CV
TS
A
I
F
L
TAMAPNLL
L
I
GL
M
KS
A
S
H
A
--
TL
SWG
D
WFL
GM
LP
L
S
I
L
L
V
L
L
V
PW
M
A
YVLYPP
VL
K
SG
D
Q
V
P
R
WA
ET
EL
QA
MGPL
CS
REK
R
M
LGL
M
V
G
AL
V
LWIFG
GDY
--
IDA
A
M
VG
YS
VVALMLL
--
L
R
I
I
C
W
D
DIV
S
NK
A
AWN
VF
F
WLA
S
LI
T
LA
T
GL
N
NT
GFI
S
WF
G
KLLAG
S
L
S
G
Y
SP
TM
----
VMV
A
LI
V
VFY
LL
RYFFAS
A
T
AYT
S
A
LA
P
M
MI
A
A
A
LAM
P
---
E
I
PL
PVF
CL
M
V
GA
A
IG
L
G
S
I
LTPYATGP
S
PI
Y
YG
S
GY
LPTA
DYWRLGAIFG
L
I
-
FLVLL
V
I
T
G
fig|585057.6.peg.3688
Escherichia coli IAI39 (11-478/487)
LAPLAV
IA
II
A
LIP
V
PAGL
ESH
T
W
L
YFAVF
T
G
V
IVGLILEP
V
P
GA
VV
AM
VGI
S
I
IA
I
L
S
PW
LLF
SPEQ
LA
Q
P
G
F
KFT
A
KS
L
S
W
A
V
SGFS
N
S
V
I
WL
I
F
A
AF
M
F
GT
GYE
K
TGLGRRIAL
I
LVKKMG
H
RTL
F
LGYA
V
M
F
S
E
L
I
LAP
V
TPSN
S
AR
G
A
GI
I
Y
PII
R
NLPPL
YQ
S
Q
PNDSS
S
R
S
IG
S
Y
I
MWM
GI
V
A
D
CV
TS
A
I
F
L
TAMAPNLL
L
I
GL
M
KS
A
S
H
A
--
TL
SWG
D
WFL
GM
LP
L
S
I
L
L
V
L
L
V
PW
M
A
YVLYPP
VL
K
SG
D
Q
V
P
R
WA
ET
EL
QA
MGPL
CS
REK
R
M
LGL
M
V
G
AL
V
LWIFG
GDY
--
IDA
A
M
VG
YS
VVALMLL
--
L
R
I
I
C
W
D
DIV
S
NK
A
AWN
VF
F
WLA
S
LI
T
LA
T
GL
N
NT
GFI
S
WF
G
KLLAG
S
L
S
G
Y
SP
TM
----
VMV
A
LI
V
VFY
LL
RYFFAS
A
T
AYT
S
A
LA
P
M
MI
A
A
A
LAM
P
---
E
I
PL
PVF
CL
M
V
GA
A
IG
L
G
S
I
LTPYATGP
S
PI
Y
YG
S
GY
LPTA
DYWRLGAIFG
L
I
-
FLVLL
V
I
T
G
fig|358709.5.peg.1177
Escherichia coli 101-1 (11-478/487)
LAPLAV
IA
II
A
L
L
P
V
PAGL
ENH
T
W
L
YFAVF
T
G
V
IVGLILEP
V
P
GA
VV
AM
VGI
S
I
IA
I
L
S
PW
LLF
SPEQ
LA
Q
P
G
F
KFT
A
KS
L
S
W
A
V
SGFS
N
S
V
I
WL
I
F
A
AF
M
F
GT
GYE
K
TGLGRRIAL
I
LVKKMG
H
RTL
F
LGYA
V
M
F
S
E
L
I
LAP
V
TPSN
S
AR
G
A
GI
I
Y
PII
R
NLPPL
YQ
S
Q
PNDSS
S
R
S
IG
S
Y
I
MWM
GI
V
A
D
CV
TS
A
I
F
L
TAMAPNLL
L
I
GL
M
KS
A
S
H
A
--
TL
SWG
D
WFL
GM
LP
L
S
I
L
L
V
L
L
V
PWL
A
YVLYPP
VL
K
SG
D
Q
V
P
R
WA
ET
EL
QA
MGPL
CS
REK
R
M
LGL
M
V
G
AL
V
LWIFG
GDY
--
IDA
A
M
VG
YS
VVALMLL
--
L
R
I
I
S
W
D
DIV
S
NK
A
AWN
VF
F
WLA
S
LI
T
LA
T
GL
N
NT
GFI
S
WF
G
KLLAG
S
L
S
G
Y
SP
TM
----
VMV
A
LI
V
VFY
LL
RYFFAS
A
T
AYT
S
A
LA
P
M
MI
A
A
A
LAM
P
---
E
I
PL
PVF
CL
M
V
GA
A
IG
L
G
S
I
LTPYATGP
S
PI
Y
YG
S
GY
LPTA
DYWRLGAIFG
L
I
-
FLVLL
V
I
T
G
fig|481805.3.peg.677
Escherichia coli ATCC 8739 (11-478/487)
LAPLAV
IA
II
A
L
L
P
V
PAGL
ENH
T
W
L
YFAVF
T
G
V
IVGLILEP
V
P
GA
VV
AM
VGI
S
I
IA
I
L
S
PW
LLF
SPEQ
LA
Q
P
G
F
KFT
A
KS
L
S
W
A
V
SGFS
N
S
V
I
WL
I
F
A
AF
M
F
GT
GYE
K
TGLGRRIAL
I
LVKKMG
H
RTL
F
LGYA
V
M
F
S
E
L
I
LAP
V
TPSN
S
AR
G
A
GI
I
Y
PII
R
NLPPL
YQ
S
Q
PNDSS
S
R
S
IG
S
Y
I
MWM
GI
V
A
D
CV
TS
A
I
F
L
TAMAPNLL
L
I
GL
M
KS
A
S
H
A
--
TL
SWG
D
WFL
GM
LP
L
S
I
L
L
V
L
L
V
PWL
A
YVLYPP
VL
K
SG
D
Q
V
P
R
WA
ET
EL
QA
MGPL
CS
REK
R
M
LGL
M
V
G
AL
V
LWIFG
GDY
--
IDA
A
M
VG
YS
VVALMLL
--
L
R
I
I
S
W
D
DIV
S
NK
A
AWN
VF
F
WLA
S
LI
T
LA
T
GL
N
NT
GFI
S
WF
G
KLLAG
S
L
S
G
Y
SP
TM
----
VMV
A
LI
V
VFY
LL
RYFFAS
A
T
AYT
S
A
LA
P
M
MI
A
A
A
LAM
P
---
E
I
PL
PVF
CL
M
V
GA
A
IG
L
G
S
I
LTPYATGP
S
PI
Y
YG
S
GY
LPTA
DYWRLGAIFG
L
I
-
FLVLL
V
I
T
G
fig|481805.6.peg.675
Escherichia coli ATCC 8739 (11-478/487)
LAPLAV
IA
II
A
L
L
P
V
PAGL
ENH
T
W
L
YFAVF
T
G
V
IVGLILEP
V
P
GA
VV
AM
VGI
S
I
IA
I
L
S
PW
LLF
SPEQ
LA
Q
P
G
F
KFT
A
KS
L
S
W
A
V
SGFS
N
S
V
I
WL
I
F
A
AF
M
F
GT
GYE
K
TGLGRRIAL
I
LVKKMG
H
RTL
F
LGYA
V
M
F
S
E
L
I
LAP
V
TPSN
S
AR
G
A
GI
I
Y
PII
R
NLPPL
YQ
S
Q
PNDSS
S
R
S
IG
S
Y
I
MWM
GI
V
A
D
CV
TS
A
I
F
L
TAMAPNLL
L
I
GL
M
KS
A
S
H
A
--
TL
SWG
D
WFL
GM
LP
L
S
I
L
L
V
L
L
V
PWL
A
YVLYPP
VL
K
SG
D
Q
V
P
R
WA
ET
EL
QA
MGPL
CS
REK
R
M
LGL
M
V
G
AL
V
LWIFG
GDY
--
IDA
A
M
VG
YS
VVALMLL
--
L
R
I
I
S
W
D
DIV
S
NK
A
AWN
VF
F
WLA
S
LI
T
LA
T
GL
N
NT
GFI
S
WF
G
KLLAG
S
L
S
G
Y
SP
TM
----
VMV
A
LI
V
VFY
LL
RYFFAS
A
T
AYT
S
A
LA
P
M
MI
A
A
A
LAM
P
---
E
I
PL
PVF
CL
M
V
GA
A
IG
L
G
S
I
LTPYATGP
S
PI
Y
YG
S
GY
LPTA
DYWRLGAIFG
L
I
-
FLVLL
V
I
T
G
fig|595496.3.peg.3041
Escherichia coli BW2952 (11-478/487)
LAPLAV
IA
II
A
L
L
P
V
PAGL
ENH
T
W
L
YFAVF
T
G
V
IVGLILEP
V
P
GA
VV
AM
VGI
S
I
IA
I
L
S
PW
LLF
SPEQ
LA
Q
P
G
F
KFT
A
KS
L
S
W
A
V
SGFS
N
S
V
I
WL
I
F
A
AF
M
F
GT
GYE
K
TGLGRRIAL
I
LVKKMG
H
RTL
F
LGYA
V
M
F
S
E
L
I
LAP
V
TPSN
S
AR
G
A
GI
I
Y
PII
R
NLPPL
YQ
S
Q
PNDSS
S
R
S
IG
S
Y
I
MWM
GI
V
A
D
CV
TS
A
I
F
L
TAMAPNLL
L
I
GL
M
KS
A
S
H
A
--
TL
SWG
D
WFL
GM
LP
L
S
I
L
L
V
L
L
V
PWL
A
YVLYPP
VL
K
SG
D
Q
V
P
R
WA
ET
EL
QA
MGPL
CS
REK
R
M
LGL
M
V
G
AL
V
LWIFG
GDY
--
IDA
A
M
VG
YS
VVALMLL
--
L
R
I
I
S
W
D
DIV
S
NK
A
AWN
VF
F
WLA
S
LI
T
LA
T
GL
N
NT
GFI
S
WF
G
KLLAG
S
L
S
G
Y
SP
TM
----
VMV
A
LI
V
VFY
LL
RYFFAS
A
T
AYT
S
A
LA
P
M
MI
A
A
A
LAM
P
---
E
I
PL
PVF
CL
M
V
GA
A
IG
L
G
S
I
LTPYATGP
S
PI
Y
YG
S
GY
LPTA
DYWRLGAIFG
L
I
-
FLVLL
V
I
T
G
fig|536056.3.peg.667
Escherichia coli DH1 (11-478/487)
LAPLAV
IA
II
A
L
L
P
V
PAGL
ENH
T
W
L
YFAVF
T
G
V
IVGLILEP
V
P
GA
VV
AM
VGI
S
I
IA
I
L
S
PW
LLF
SPEQ
LA
Q
P
G
F
KFT
A
KS
L
S
W
A
V
SGFS
N
S
V
I
WL
I
F
A
AF
M
F
GT
GYE
K
TGLGRRIAL
I
LVKKMG
H
RTL
F
LGYA
V
M
F
S
E
L
I
LAP
V
TPSN
S
AR
G
A
GI
I
Y
PII
R
NLPPL
YQ
S
Q
PNDSS
S
R
S
IG
S
Y
I
MWM
GI
V
A
D
CV
TS
A
I
F
L
TAMAPNLL
L
I
GL
M
KS
A
S
H
A
--
TL
SWG
D
WFL
GM
LP
L
S
I
L
L
V
L
L
V
PWL
A
YVLYPP
VL
K
SG
D
Q
V
P
R
WA
ET
EL
QA
MGPL
CS
REK
R
M
LGL
M
V
G
AL
V
LWIFG
GDY
--
IDA
A
M
VG
YS
VVALMLL
--
L
R
I
I
S
W
D
DIV
S
NK
A
AWN
VF
F
WLA
S
LI
T
LA
T
GL
N
NT
GFI
S
WF
G
KLLAG
S
L
S
G
Y
SP
TM
----
VMV
A
LI
V
VFY
LL
RYFFAS
A
T
AYT
S
A
LA
P
M
MI
A
A
A
LAM
P
---
E
I
PL
PVF
CL
M
V
GA
A
IG
L
G
S
I
LTPYATGP
S
PI
Y
YG
S
GY
LPTA
DYWRLGAIFG
L
I
-
FLVLL
V
I
T
G
fig|316401.4.peg.3784
Escherichia coli ETEC H10407 (11-478/487)
LAPLAV
IA
II
A
L
L
P
V
PAGL
ENH
T
W
L
YFAVF
T
G
V
IVGLILEP
V
P
GA
VV
AM
VGI
S
I
IA
I
L
S
PW
LLF
SPEQ
LA
Q
P
G
F
KFT
A
KS
L
S
W
A
V
SGFS
N
S
V
I
WL
I
F
A
AF
M
F
GT
GYE
K
TGLGRRIAL
I
LVKKMG
H
RTL
F
LGYA
V
M
F
S
E
L
I
LAP
V
TPSN
S
AR
G
A
GI
I
Y
PII
R
NLPPL
YQ
S
Q
PNDSS
S
R
S
IG
S
Y
I
MWM
GI
V
A
D
CV
TS
A
I
F
L
TAMAPNLL
L
I
GL
M
KS
A
S
H
A
--
TL
SWG
D
WFL
GM
LP
L
S
I
L
L
V
L
L
V
PWL
A
YVLYPP
VL
K
SG
D
Q
V
P
R
WA
ET
EL
QA
MGPL
CS
REK
R
M
LGL
M
V
G
AL
V
LWIFG
GDY
--
IDA
A
M
VG
YS
VVALMLL
--
L
R
I
I
S
W
D
DIV
S
NK
A
AWN
VF
F
WLA
S
LI
T
LA
T
GL
N
NT
GFI
S
WF
G
KLLAG
S
L
S
G
Y
SP
TM
----
VMV
A
LI
V
VFY
LL
RYFFAS
A
T
AYT
S
A
LA
P
M
MI
A
A
A
LAM
P
---
E
I
PL
PVF
CL
M
V
GA
A
IG
L
G
S
I
LTPYATGP
S
PI
Y
YG
S
GY
LPTA
DYWRLGAIFG
L
I
-
FLVLL
V
I
T
G
fig|656414.3.peg.3527
Escherichia coli H736 (11-478/487)
LAPLAV
IA
II
A
L
L
P
V
PAGL
ENH
T
W
L
YFAVF
T
G
V
IVGLILEP
V
P
GA
VV
AM
VGI
S
I
IA
I
L
S
PW
LLF
SPEQ
LA
Q
P
G
F
KFT
A
KS
L
S
W
A
V
SGFS
N
S
V
I
WL
I
F
A
AF
M
F
GT
GYE
K
TGLGRRIAL
I
LVKKMG
H
RTL
F
LGYA
V
M
F
S
E
L
I
LAP
V
TPSN
S
AR
G
A
GI
I
Y
PII
R
NLPPL
YQ
S
Q
PNDSS
S
R
S
IG
S
Y
I
MWM
GI
V
A
D
CV
TS
A
I
F
L
TAMAPNLL
L
I
GL
M
KS
A
S
H
A
--
TL
SWG
D
WFL
GM
LP
L
S
I
L
L
V
L
L
V
PWL
A
YVLYPP
VL
K
SG
D
Q
V
P
R
WA
ET
EL
QA
MGPL
CS
REK
R
M
LGL
M
V
G
AL
V
LWIFG
GDY
--
IDA
A
M
VG
YS
VVALMLL
--
L
R
I
I
S
W
D
DIV
S
NK
A
AWN
VF
F
WLA
S
LI
T
LA
T
GL
N
NT
GFI
S
WF
G
KLLAG
S
L
S
G
Y
SP
TM
----
VMV
A
LI
V
VFY
LL
RYFFAS
A
T
AYT
S
A
LA
P
M
MI
A
A
A
LAM
P
---
E
I
PL
PVF
CL
M
V
GA
A
IG
L
G
S
I
LTPYATGP
S
PI
Y
YG
S
GY
LPTA
DYWRLGAIFG
L
I
-
FLVLL
V
I
T
G
fig|585034.4.peg.3145
Escherichia coli IAI1 (11-478/487)
LAPLAV
IA
II
A
L
L
P
V
PAGL
ENH
T
W
L
YFAVF
T
G
V
IVGLILEP
V
P
GA
VV
AM
VGI
S
I
IA
I
L
S
PW
LLF
SPEQ
LA
Q
P
G
F
KFT
A
KS
L
S
W
A
V
SGFS
N
S
V
I
WL
I
F
A
AF
M
F
GT
GYE
K
TGLGRRIAL
I
LVKKMG
H
RTL
F
LGYA
V
M
F
S
E
L
I
LAP
V
TPSN
S
AR
G
A
GI
I
Y
PII
R
NLPPL
YQ
S
Q
PNDSS
S
R
S
IG
S
Y
I
MWM
GI
V
A
D
CV
TS
A
I
F
L
TAMAPNLL
L
I
GL
M
KS
A
S
H
A
--
TL
SWG
D
WFL
GM
LP
L
S
I
L
L
V
L
L
V
PWL
A
YVLYPP
VL
K
SG
D
Q
V
P
R
WA
ET
EL
QA
MGPL
CS
REK
R
M
LGL
M
V
G
AL
V
LWIFG
GDY
--
IDA
A
M
VG
YS
VVALMLL
--
L
R
I
I
S
W
D
DIV
S
NK
A
AWN
VF
F
WLA
S
LI
T
LA
T
GL
N
NT
GFI
S
WF
G
KLLAG
S
L
S
G
Y
SP
TM
----
VMV
A
LI
V
VFY
LL
RYFFAS
A
T
AYT
S
A
LA
P
M
MI
A
A
A
LAM
P
---
E
I
PL
PVF
CL
M
V
GA
A
IG
L
G
S
I
LTPYATGP
S
PI
Y
YG
S
GY
LPTA
DYWRLGAIFG
L
I
-
FLVLL
V
I
T
G
fig|585034.5.peg.3143
Escherichia coli IAI1 (11-478/487)
LAPLAV
IA
II
A
L
L
P
V
PAGL
ENH
T
W
L
YFAVF
T
G
V
IVGLILEP
V
P
GA
VV
AM
VGI
S
I
IA
I
L
S
PW
LLF
SPEQ
LA
Q
P
G
F
KFT
A
KS
L
S
W
A
V
SGFS
N
S
V
I
WL
I
F
A
AF
M
F
GT
GYE
K
TGLGRRIAL
I
LVKKMG
H
RTL
F
LGYA
V
M
F
S
E
L
I
LAP
V
TPSN
S
AR
G
A
GI
I
Y
PII
R
NLPPL
YQ
S
Q
PNDSS
S
R
S
IG
S
Y
I
MWM
GI
V
A
D
CV
TS
A
I
F
L
TAMAPNLL
L
I
GL
M
KS
A
S
H
A
--
TL
SWG
D
WFL
GM
LP
L
S
I
L
L
V
L
L
V
PWL
A
YVLYPP
VL
K
SG
D
Q
V
P
R
WA
ET
EL
QA
MGPL
CS
REK
R
M
LGL
M
V
G
AL
V
LWIFG
GDY
--
IDA
A
M
VG
YS
VVALMLL
--
L
R
I
I
S
W
D
DIV
S
NK
A
AWN
VF
F
WLA
S
LI
T
LA
T
GL
N
NT
GFI
S
WF
G
KLLAG
S
L
S
G
Y
SP
TM
----
VMV
A
LI
V
VFY
LL
RYFFAS
A
T
AYT
S
A
LA
P
M
MI
A
A
A
LAM
P
---
E
I
PL
PVF
CL
M
V
GA
A
IG
L
G
S
I
LTPYATGP
S
PI
Y
YG
S
GY
LPTA
DYWRLGAIFG
L
I
-
FLVLL
V
I
T
G
fig|83333.1.peg.3011
Escherichia coli K12 (11-478/487)
LAPLAV
IA
II
A
L
L
P
V
PAGL
ENH
T
W
L
YFAVF
T
G
V
IVGLILEP
V
P
GA
VV
AM
VGI
S
I
IA
I
L
S
PW
LLF
SPEQ
LA
Q
P
G
F
KFT
A
KS
L
S
W
A
V
SGFS
N
S
V
I
WL
I
F
A
AF
M
F
GT
GYE
K
TGLGRRIAL
I
LVKKMG
H
RTL
F
LGYA
V
M
F
S
E
L
I
LAP
V
TPSN
S
AR
G
A
GI
I
Y
PII
R
NLPPL
YQ
S
Q
PNDSS
S
R
S
IG
S
Y
I
MWM
GI
V
A
D
CV
TS
A
I
F
L
TAMAPNLL
L
I
GL
M
KS
A
S
H
A
--
TL
SWG
D
WFL
GM
LP
L
S
I
L
L
V
L
L
V
PWL
A
YVLYPP
VL
K
SG
D
Q
V
P
R
WA
ET
EL
QA
MGPL
CS
REK
R
M
LGL
M
V
G
AL
V
LWIFG
GDY
--
IDA
A
M
VG
YS
VVALMLL
--
L
R
I
I
S
W
D
DIV
S
NK
A
AWN
VF
F
WLA
S
LI
T
LA
T
GL
N
NT
GFI
S
WF
G
KLLAG
S
L
S
G
Y
SP
TM
----
VMV
A
LI
V
VFY
LL
RYFFAS
A
T
AYT
S
A
LA
P
M
MI
A
A
A
LAM
P
---
E
I
PL
PVF
CL
M
V
GA
A
IG
L
G
S
I
LTPYATGP
S
PI
Y
YG
S
GY
LPTA
DYWRLGAIFG
L
I
-
FLVLL
V
I
T
G
fig|749538.3.peg.3844
Escherichia coli MS 116-1 (11-478/487)
LAPLAV
IA
II
A
L
L
P
V
PAGL
ENH
T
W
L
YFAVF
T
G
V
IVGLILEP
V
P
GA
VV
AM
VGI
S
I
IA
I
L
S
PW
LLF
SPEQ
LA
Q
P
G
F
KFT
A
KS
L
S
W
A
V
SGFS
N
S
V
I
WL
I
F
A
AF
M
F
GT
GYE
K
TGLGRRIAL
I
LVKKMG
H
RTL
F
LGYA
V
M
F
S
E
L
I
LAP
V
TPSN
S
AR
G
A
GI
I
Y
PII
R
NLPPL
YQ
S
Q
PNDSS
S
R
S
IG
S
Y
I
MWM
GI
V
A
D
CV
TS
A
I
F
L
TAMAPNLL
L
I
GL
M
KS
A
S
H
A
--
TL
SWG
D
WFL
GM
LP
L
S
I
L
L
V
L
L
V
PWL
A
YVLYPP
VL
K
SG
D
Q
V
P
R
WA
ET
EL
QA
MGPL
CS
REK
R
M
LGL
M
V
G
AL
V
LWIFG
GDY
--
IDA
A
M
VG
YS
VVALMLL
--
L
R
I
I
S
W
D
DIV
S
NK
A
AWN
VF
F
WLA
S
LI
T
LA
T
GL
N
NT
GFI
S
WF
G
KLLAG
S
L
S
G
Y
SP
TM
----
VMV
A
LI
V
VFY
LL
RYFFAS
A
T
AYT
S
A
LA
P
M
MI
A
A
A
LAM
P
---
E
I
PL
PVF
CL
M
V
GA
A
IG
L
G
S
I
LTPYATGP
S
PI
Y
YG
S
GY
LPTA
DYWRLGAIFG
L
I
-
FLVLL
V
I
T
G
fig|679205.4.peg.438
Escherichia coli MS 124-1 (11-478/487)
LAPLAV
IA
II
A
L
L
P
V
PAGL
ENH
T
W
L
YFAVF
T
G
V
IVGLILEP
V
P
GA
VV
AM
VGI
S
I
IA
I
L
S
PW
LLF
SPEQ
LA
Q
P
G
F
KFT
A
KS
L
S
W
A
V
SGFS
N
S
V
I
WL
I
F
A
AF
M
F
GT
GYE
K
TGLGRRIAL
I
LVKKMG
H
RTL
F
LGYA
V
M
F
S
E
L
I
LAP
V
TPSN
S
AR
G
A
GI
I
Y
PII
R
NLPPL
YQ
S
Q
PNDSS
S
R
S
IG
S
Y
I
MWM
GI
V
A
D
CV
TS
A
I
F
L
TAMAPNLL
L
I
GL
M
KS
A
S
H
A
--
TL
SWG
D
WFL
GM
LP
L
S
I
L
L
V
L
L
V
PWL
A
YVLYPP
VL
K
SG
D
Q
V
P
R
WA
ET
EL
QA
MGPL
CS
REK
R
M
LGL
M
V
G
AL
V
LWIFG
GDY
--
IDA
A
M
VG
YS
VVALMLL
--
L
R
I
I
S
W
D
DIV
S
NK
A
AWN
VF
F
WLA
S
LI
T
LA
T
GL
N
NT
GFI
S
WF
G
KLLAG
S
L
S
G
Y
SP
TM
----
VMV
A
LI
V
VFY
LL
RYFFAS
A
T
AYT
S
A
LA
P
M
MI
A
A
A
LAM
P
---
E
I
PL
PVF
CL
M
V
GA
A
IG
L
G
S
I
LTPYATGP
S
PI
Y
YG
S
GY
LPTA
DYWRLGAIFG
L
I
-
FLVLL
V
I
T
G
fig|749548.3.peg.1085
Escherichia coli MS 196-1 (11-478/487)
LAPLAV
IA
II
A
L
L
P
V
PAGL
ENH
T
W
L
YFAVF
T
G
V
IVGLILEP
V
P
GA
VV
AM
VGI
S
I
IA
I
L
S
PW
LLF
SPEQ
LA
Q
P
G
F
KFT
A
KS
L
S
W
A
V
SGFS
N
S
V
I
WL
I
F
A
AF
M
F
GT
GYE
K
TGLGRRIAL
I
LVKKMG
H
RTL
F
LGYA
V
M
F
S
E
L
I
LAP
V
TPSN
S
AR
G
A
GI
I
Y
PII
R
NLPPL
YQ
S
Q
PNDSS
S
R
S
IG
S
Y
I
MWM
GI
V
A
D
CV
TS
A
I
F
L
TAMAPNLL
L
I
GL
M
KS
A
S
H
A
--
TL
SWG
D
WFL
GM
LP
L
S
I
L
L
V
L
L
V
PWL
A
YVLYPP
VL
K
SG
D
Q
V
P
R
WA
ET
EL
QA
MGPL
CS
REK
R
M
LGL
M
V
G
AL
V
LWIFG
GDY
--
IDA
A
M
VG
YS
VVALMLL
--
L
R
I
I
S
W
D
DIV
S
NK
A
AWN
VF
F
WLA
S
LI
T
LA
T
GL
N
NT
GFI
S
WF
G
KLLAG
S
L
S
G
Y
SP
TM
----
VMV
A
LI
V
VFY
LL
RYFFAS
A
T
AYT
S
A
LA
P
M
MI
A
A
A
LAM
P
---
E
I
PL
PVF
CL
M
V
GA
A
IG
L
G
S
I
LTPYATGP
S
PI
Y
YG
S
GY
LPTA
DYWRLGAIFG
L
I
-
FLVLL
V
I
T
G
fig|749533.3.peg.3569
Escherichia coli MS 84-1 (11-478/487)
LAPLAV
IA
II
A
L
L
P
V
PAGL
ENH
T
W
L
YFAVF
T
G
V
IVGLILEP
V
P
GA
VV
AM
VGI
S
I
IA
I
L
S
PW
LLF
SPEQ
LA
Q
P
G
F
KFT
A
KS
L
S
W
A
V
SGFS
N
S
V
I
WL
I
F
A
AF
M
F
GT
GYE
K
TGLGRRIAL
I
LVKKMG
H
RTL
F
LGYA
V
M
F
S
E
L
I
LAP
V
TPSN
S
AR
G
A
GI
I
Y
PII
R
NLPPL
YQ
S
Q
PNDSS
S
R
S
IG
S
Y
I
MWM
GI
V
A
D
CV
TS
A
I
F
L
TAMAPNLL
L
I
GL
M
KS
A
S
H
A
--
TL
SWG
D
WFL
GM
LP
L
S
I
L
L
V
L
L
V
PWL
A
YVLYPP
VL
K
SG
D
Q
V
P
R
WA
ET
EL
QA
MGPL
CS
REK
R
M
LGL
M
V
G
AL
V
LWIFG
GDY
--
IDA
A
M
VG
YS
VVALMLL
--
L
R
I
I
S
W
D
DIV
S
NK
A
AWN
VF
F
WLA
S
LI
T
LA
T
GL
N
NT
GFI
S
WF
G
KLLAG
S
L
S
G
Y
SP
TM
----
VMV
A
LI
V
VFY
LL
RYFFAS
A
T
AYT
S
A
LA
P
M
MI
A
A
A
LAM
P
---
E
I
PL
PVF
CL
M
V
GA
A
IG
L
G
S
I
LTPYATGP
S
PI
Y
YG
S
GY
LPTA
DYWRLGAIFG
L
I
-
FLVLL
V
I
T
G
fig|316407.3.peg.2949
Escherichia coli W3110 (11-478/487)
LAPLAV
IA
II
A
L
L
P
V
PAGL
ENH
T
W
L
YFAVF
T
G
V
IVGLILEP
V
P
GA
VV
AM
VGI
S
I
IA
I
L
S
PW
LLF
SPEQ
LA
Q
P
G
F
KFT
A
KS
L
S
W
A
V
SGFS
N
S
V
I
WL
I
F
A
AF
M
F
GT
GYE
K
TGLGRRIAL
I
LVKKMG
H
RTL
F
LGYA
V
M
F
S
E
L
I
LAP
V
TPSN
S
AR
G
A
GI
I
Y
PII
R
NLPPL
YQ
S
Q
PNDSS
S
R
S
IG
S
Y
I
MWM
GI
V
A
D
CV
TS
A
I
F
L
TAMAPNLL
L
I
GL
M
KS
A
S
H
A
--
TL
SWG
D
WFL
GM
LP
L
S
I
L
L
V
L
L
V
PWL
A
YVLYPP
VL
K
SG
D
Q
V
P
R
WA
ET
EL
QA
MGPL
CS
REK
R
M
LGL
M
V
G
AL
V
LWIFG
GDY
--
IDA
A
M
VG
YS
VVALMLL
--
L
R
I
I
S
W
D
DIV
S
NK
A
AWN
VF
F
WLA
S
LI
T
LA
T
GL
N
NT
GFI
S
WF
G
KLLAG
S
L
S
G
Y
SP
TM
----
VMV
A
LI
V
VFY
LL
RYFFAS
A
T
AYT
S
A
LA
P
M
MI
A
A
A
LAM
P
---
E
I
PL
PVF
CL
M
V
GA
A
IG
L
G
S
I
LTPYATGP
S
PI
Y
YG
S
GY
LPTA
DYWRLGAIFG
L
I
-
FLVLL
V
I
T
G
fig|316385.5.peg.3191
Escherichia coli str. K-12 substr. DH10B (11-478/487)
LAPLAV
IA
II
A
L
L
P
V
PAGL
ENH
T
W
L
YFAVF
T
G
V
IVGLILEP
V
P
GA
VV
AM
VGI
S
I
IA
I
L
S
PW
LLF
SPEQ
LA
Q
P
G
F
KFT
A
KS
L
S
W
A
V
SGFS
N
S
V
I
WL
I
F
A
AF
M
F
GT
GYE
K
TGLGRRIAL
I
LVKKMG
H
RTL
F
LGYA
V
M
F
S
E
L
I
LAP
V
TPSN
S
AR
G
A
GI
I
Y
PII
R
NLPPL
YQ
S
Q
PNDSS
S
R
S
IG
S
Y
I
MWM
GI
V
A
D
CV
TS
A
I
F
L
TAMAPNLL
L
I
GL
M
KS
A
S
H
A
--
TL
SWG
D
WFL
GM
LP
L
S
I
L
L
V
L
L
V
PWL
A
YVLYPP
VL
K
SG
D
Q
V
P
R
WA
ET
EL
QA
MGPL
CS
REK
R
M
LGL
M
V
G
AL
V
LWIFG
GDY
--
IDA
A
M
VG
YS
VVALMLL
--
L
R
I
I
S
W
D
DIV
S
NK
A
AWN
VF
F
WLA
S
LI
T
LA
T
GL
N
NT
GFI
S
WF
G
KLLAG
S
L
S
G
Y
SP
TM
----
VMV
A
LI
V
VFY
LL
RYFFAS
A
T
AYT
S
A
LA
P
M
MI
A
A
A
LAM
P
---
E
I
PL
PVF
CL
M
V
GA
A
IG
L
G
S
I
LTPYATGP
S
PI
Y
YG
S
GY
LPTA
DYWRLGAIFG
L
I
-
FLVLL
V
I
T
G
fig|316385.7.peg.3260
Escherichia coli str. K-12 substr. DH10B (11-478/487)
LAPLAV
IA
II
A
L
L
P
V
PAGL
ENH
T
W
L
YFAVF
T
G
V
IVGLILEP
V
P
GA
VV
AM
VGI
S
I
IA
I
L
S
PW
LLF
SPEQ
LA
Q
P
G
F
KFT
A
KS
L
S
W
A
V
SGFS
N
S
V
I
WL
I
F
A
AF
M
F
GT
GYE
K
TGLGRRIAL
I
LVKKMG
H
RTL
F
LGYA
V
M
F
S
E
L
I
LAP
V
TPSN
S
AR
G
A
GI
I
Y
PII
R
NLPPL
YQ
S
Q
PNDSS
S
R
S
IG
S
Y
I
MWM
GI
V
A
D
CV
TS
A
I
F
L
TAMAPNLL
L
I
GL
M
KS
A
S
H
A
--
TL
SWG
D
WFL
GM
LP
L
S
I
L
L
V
L
L
V
PWL
A
YVLYPP
VL
K
SG
D
Q
V
P
R
WA
ET
EL
QA
MGPL
CS
REK
R
M
LGL
M
V
G
AL
V
LWIFG
GDY
--
IDA
A
M
VG
YS
VVALMLL
--
L
R
I
I
S
W
D
DIV
S
NK
A
AWN
VF
F
WLA
S
LI
T
LA
T
GL
N
NT
GFI
S
WF
G
KLLAG
S
L
S
G
Y
SP
TM
----
VMV
A
LI
V
VFY
LL
RYFFAS
A
T
AYT
S
A
LA
P
M
MI
A
A
A
LAM
P
---
E
I
PL
PVF
CL
M
V
GA
A
IG
L
G
S
I
LTPYATGP
S
PI
Y
YG
S
GY
LPTA
DYWRLGAIFG
L
I
-
FLVLL
V
I
T
G
fig|511145.12.peg.3157
Escherichia coli str. K-12 substr. MG1655 (11-478/487)
LAPLAV
IA
II
A
L
L
P
V
PAGL
ENH
T
W
L
YFAVF
T
G
V
IVGLILEP
V
P
GA
VV
AM
VGI
S
I
IA
I
L
S
PW
LLF
SPEQ
LA
Q
P
G
F
KFT
A
KS
L
S
W
A
V
SGFS
N
S
V
I
WL
I
F
A
AF
M
F
GT
GYE
K
TGLGRRIAL
I
LVKKMG
H
RTL
F
LGYA
V
M
F
S
E
L
I
LAP
V
TPSN
S
AR
G
A
GI
I
Y
PII
R
NLPPL
YQ
S
Q
PNDSS
S
R
S
IG
S
Y
I
MWM
GI
V
A
D
CV
TS
A
I
F
L
TAMAPNLL
L
I
GL
M
KS
A
S
H
A
--
TL
SWG
D
WFL
GM
LP
L
S
I
L
L
V
L
L
V
PWL
A
YVLYPP
VL
K
SG
D
Q
V
P
R
WA
ET
EL
QA
MGPL
CS
REK
R
M
LGL
M
V
G
AL
V
LWIFG
GDY
--
IDA
A
M
VG
YS
VVALMLL
--
L
R
I
I
S
W
D
DIV
S
NK
A
AWN
VF
F
WLA
S
LI
T
LA
T
GL
N
NT
GFI
S
WF
G
KLLAG
S
L
S
G
Y
SP
TM
----
VMV
A
LI
V
VFY
LL
RYFFAS
A
T
AYT
S
A
LA
P
M
MI
A
A
A
LAM
P
---
E
I
PL
PVF
CL
M
V
GA
A
IG
L
G
S
I
LTPYATGP
S
PI
Y
YG
S
GY
LPTA
DYWRLGAIFG
L
I
-
FLVLL
V
I
T
G
fig|511145.6.peg.3142
Escherichia coli str. K-12 substr. MG1655 (11-478/487)
LAPLAV
IA
II
A
L
L
P
V
PAGL
ENH
T
W
L
YFAVF
T
G
V
IVGLILEP
V
P
GA
VV
AM
VGI
S
I
IA
I
L
S
PW
LLF
SPEQ
LA
Q
P
G
F
KFT
A
KS
L
S
W
A
V
SGFS
N
S
V
I
WL
I
F
A
AF
M
F
GT
GYE
K
TGLGRRIAL
I
LVKKMG
H
RTL
F
LGYA
V
M
F
S
E
L
I
LAP
V
TPSN
S
AR
G
A
GI
I
Y
PII
R
NLPPL
YQ
S
Q
PNDSS
S
R
S
IG
S
Y
I
MWM
GI
V
A
D
CV
TS
A
I
F
L
TAMAPNLL
L
I
GL
M
KS
A
S
H
A
--
TL
SWG
D
WFL
GM
LP
L
S
I
L
L
V
L
L
V
PWL
A
YVLYPP
VL
K
SG
D
Q
V
P
R
WA
ET
EL
QA
MGPL
CS
REK
R
M
LGL
M
V
G
AL
V
LWIFG
GDY
--
IDA
A
M
VG
YS
VVALMLL
--
L
R
I
I
S
W
D
DIV
S
NK
A
AWN
VF
F
WLA
S
LI
T
LA
T
GL
N
NT
GFI
S
WF
G
KLLAG
S
L
S
G
Y
SP
TM
----
VMV
A
LI
V
VFY
LL
RYFFAS
A
T
AYT
S
A
LA
P
M
MI
A
A
A
LAM
P
---
E
I
PL
PVF
CL
M
V
GA
A
IG
L
G
S
I
LTPYATGP
S
PI
Y
YG
S
GY
LPTA
DYWRLGAIFG
L
I
-
FLVLL
V
I
T
G
fig|550677.3.peg.3626
Escherichia coli B354 (11-478/487)
LAPLAV
IA
II
A
LIP
V
PAGL
ESH
T
W
L
YFAVF
T
G
V
IVGLILEP
V
P
GA
VV
AM
VGI
S
I
IA
I
L
S
PW
LLF
SPEQ
LA
Q
P
G
F
KFT
A
KS
L
S
W
A
V
SGFS
N
S
V
I
WL
I
F
A
AF
M
F
GT
GYE
K
TGLGRRIAL
I
LVKKMG
H
RTL
F
LGYA
V
M
F
S
E
L
I
LAP
V
TPSN
S
AR
G
A
GI
I
Y
PII
R
NLPPL
YQ
S
Q
PNDSS
S
R
S
IG
S
Y
I
MWM
GI
V
A
D
CV
TS
A
I
F
L
TAMAPNLL
L
I
GL
M
KS
A
S
H
A
--
TL
SWG
D
WFL
GM
LP
L
S
I
L
L
V
L
L
V
PWL
A
YVLYPP
VL
K
SG
D
Q
V
P
R
WA
ET
EL
QA
MGPL
CS
REK
R
M
LGL
M
V
G
AL
V
LWIFG
GDY
--
IDA
A
M
VG
YS
VVALMLL
--
L
R
I
I
C
W
D
DIV
S
NK
A
AWN
VF
F
WLA
S
LI
T
LA
T
GL
N
NT
GFI
S
WF
G
KLLAG
S
L
S
G
Y
SP
TM
----
VMV
A
LI
V
VFY
LL
RYFFAS
A
T
AYT
S
A
LA
P
M
MI
A
A
A
LAM
P
---
E
I
PL
PVF
CL
M
V
GA
A
IG
L
G
S
I
LTPYATGP
S
PI
Y
YG
S
GY
LPTV
DYWRLGAIFG
L
I
-
FLVLL
V
I
T
G
fig|749537.3.peg.1168
Escherichia coli MS 115-1 (11-478/487)
LAPLAV
IA
II
A
L
L
P
V
PAGL
ENH
T
W
L
YFAVF
T
G
V
IVGLILEP
V
P
GA
VV
AM
VGI
S
I
IA
I
L
S
PW
LLF
SPEQ
LA
Q
P
G
F
KFT
A
KS
L
S
W
A
V
SGFS
N
S
V
I
WL
I
F
A
AF
M
F
GT
GYE
K
TGLGRRIAL
I
LVKKMG
H
RTL
F
LGYA
V
M
F
S
E
L
I
LAP
V
TPSN
S
AR
G
A
GI
I
Y
PII
R
NLPPL
YQ
S
Q
PNDSS
S
R
S
IG
S
Y
I
MWM
GI
V
A
D
CV
TS
A
I
F
L
TAMAPNLL
L
I
GL
M
KS
A
S
H
A
--
TL
SWG
D
WFL
GM
LP
L
S
I
L
L
V
L
L
V
PWL
A
YVLYPP
VL
K
SG
D
Q
V
P
R
WA
ET
EL
QA
MGPL
CS
REK
R
M
LGL
M
V
G
AL
V
LWIFG
GDY
--
IDA
A
M
VG
YS
VVALMLL
--
L
R
I
I
S
W
D
DIV
S
NK
A
AWN
VF
F
WLA
S
LI
T
LA
T
GL
N
NT
GFI
S
WF
G
KLLAG
S
L
S
G
Y
SP
TL
----
VMV
A
LI
V
VFY
LL
RYFFAS
A
T
AYT
S
A
LA
P
M
MI
A
A
A
LAM
P
---
E
I
PL
PVF
CL
M
V
GA
A
IG
L
G
S
I
LTPYATGP
S
PI
Y
YG
S
GY
LPTA
DYWRLGAIFG
L
I
-
FLVLL
V
I
T
G
fig|685038.3.peg.3114
Escherichia coli O83:H1 str. NRG 857C (11-478/487)
LAPLAV
IA
II
A
LIP
V
PAGL
ESH
T
W
L
YFAVF
T
G
V
IVGLILEP
V
P
GA
VV
AM
VGI
S
I
IA
I
L
S
PW
LLF
SPEQ
LA
Q
P
G
F
KFT
A
KS
L
S
W
A
V
SGFS
N
S
V
I
WL
I
F
S
AF
M
F
GT
GYE
K
TGLGRRIAL
I
LVKKMG
H
RTL
F
LGYA
V
M
F
S
E
L
I
LAP
V
TPSN
S
AR
G
A
GI
I
Y
PII
R
NLPPL
YQ
S
Q
PNDSS
S
R
S
IG
S
Y
I
MWM
GI
V
A
D
CV
TS
A
I
F
L
TAMAPNLL
L
I
GL
M
KS
A
S
H
A
--
TL
SWG
D
WFL
GM
LP
L
S
I
L
L
V
L
L
V
PWL
A
YVLYPP
VL
K
SG
D
Q
V
P
R
WA
ET
EL
QA
MGPL
CS
REK
R
M
LGL
M
V
G
AL
V
LWIFG
GDY
--
IDA
A
M
VG
YS
VVALMLL
--
L
R
I
I
C
W
D
DIV
S
NK
A
AWN
VF
F
WLA
S
LI
T
LA
T
GL
N
NT
GFI
S
WF
G
KLLAG
S
L
S
G
Y
SP
TM
----
VMV
A
LI
V
VFY
LL
RYFFAS
A
T
AYT
S
A
LA
P
M
MV
A
A
A
LAM
P
---
E
I
PL
PVF
CL
M
V
GA
A
IG
L
G
S
I
LTPYATGP
S
PI
Y
YG
S
GY
LPTV
DYWRLGAIFG
L
I
-
FLVLL
V
I
T
G
fig|550676.3.peg.3218
Escherichia coli B185 (11-478/487)
LAPLAV
IA
II
A
LIP
V
PAGL
ESH
T
W
L
YFAVF
T
G
V
IVGLILEP
V
P
GA
VV
AM
VGI
S
I
IA
I
L
S
PW
LLF
SPEQ
LA
Q
P
G
F
KFT
A
KS
L
S
W
A
V
SGFS
N
S
V
I
WL
I
F
A
AF
M
F
GT
GYE
K
TGLGRRIAL
I
LVKKMG
H
RTL
F
LGYA
V
M
F
S
E
L
I
LAP
V
TPSN
S
AR
G
A
GI
I
Y
PII
R
NLPPL
YQ
S
Q
PNDSS
S
R
S
IG
S
Y
I
MWM
GI
V
A
D
CV
TS
A
I
F
L
TAMAPNLL
L
I
GL
M
KS
A
S
H
A
--
TL
G
WG
D
WFL
GM
LP
L
S
I
L
L
V
L
L
I
PWL
A
YVLYPP
VL
K
SG
D
Q
V
P
R
WA
ET
EL
QA
MGPL
CS
REK
R
M
LGL
M
V
G
AL
V
LWIFG
GDY
--
IDA
A
M
VG
YS
VVALMLL
--
L
R
I
I
S
W
D
DIV
S
NK
A
AWN
VF
F
WLA
S
LI
T
LA
T
GL
N
NT
GFI
S
WF
G
KLLAG
S
L
S
G
Y
SP
TM
----
VMV
A
LI
V
VFY
LL
RYFFAS
A
T
AYT
S
A
LA
P
M
MI
A
A
A
LAM
P
---
E
I
PL
PVF
CL
M
V
GA
A
IG
L
G
S
I
LTPYATGP
S
PI
Y
YG
S
GY
LPTA
DYWRLGAIFG
L
I
-
FLVLL
V
I
T
G
fig|340197.3.peg.2585
Escherichia coli F11 (11-478/487)
LAPLAV
IA
II
A
L
L
P
L
PAGL
ESH
T
W
L
YFAVF
T
G
V
IVGLILEP
V
P
GA
VV
AM
VGI
S
I
IA
I
L
S
PW
LLF
SPEQ
LA
Q
P
G
F
KFT
A
KS
L
S
W
A
V
SGFS
N
S
V
I
WL
I
F
A
AF
M
F
GT
GYE
K
TGLGRRIAL
I
LVKKMG
H
RTL
F
LGYA
V
M
F
S
E
L
I
LAP
V
TPSN
S
AR
G
A
GI
I
Y
PII
R
NLPPL
YQ
S
Q
PNDSS
S
R
S
IG
S
Y
I
MWM
GI
V
A
D
CV
TS
A
I
F
L
TAMAPNLL
L
I
GL
M
KS
A
S
H
A
--
TL
SWG
D
WFL
GM
LP
L
S
I
L
L
V
L
L
V
PWL
A
YVLYPP
I
L
K
SG
D
Q
V
P
R
WA
ET
EL
QA
MGPL
CS
REK
R
M
LGL
M
V
G
AL
V
LWIFG
GDY
--
IDA
A
M
VG
YS
VVALMLL
--
L
R
I
I
S
W
D
DIV
S
NK
A
AWN
VF
F
WLA
S
LI
T
LA
T
GL
N
NT
GFI
S
WF
G
KLLAG
S
L
S
G
Y
SP
TI
----
VMV
A
LI
V
VFY
LL
RYFFAS
A
T
AYT
S
A
LA
P
M
MI
A
A
A
LAM
P
---
E
I
PL
PVF
CL
M
V
GA
A
IG
L
G
S
I
LTPYATGP
S
PI
Y
YG
S
GY
LPTA
DYWRLGAIFG
L
I
-
FLVLL
V
I
T
G
fig|340197.5.peg.2709
Escherichia coli F11 (11-478/487)
LAPLAV
IA
II
A
L
L
P
L
PAGL
ESH
T
W
L
YFAVF
T
G
V
IVGLILEP
V
P
GA
VV
AM
VGI
S
I
IA
I
L
S
PW
LLF
SPEQ
LA
Q
P
G
F
KFT
A
KS
L
S
W
A
V
SGFS
N
S
V
I
WL
I
F
A
AF
M
F
GT
GYE
K
TGLGRRIAL
I
LVKKMG
H
RTL
F
LGYA
V
M
F
S
E
L
I
LAP
V
TPSN
S
AR
G
A
GI
I
Y
PII
R
NLPPL
YQ
S
Q
PNDSS
S
R
S
IG
S
Y
I
MWM
GI
V
A
D
CV
TS
A
I
F
L
TAMAPNLL
L
I
GL
M
KS
A
S
H
A
--
TL
SWG
D
WFL
GM
LP
L
S
I
L
L
V
L
L
V
PWL
A
YVLYPP
I
L
K
SG
D
Q
V
P
R
WA
ET
EL
QA
MGPL
CS
REK
R
M
LGL
M
V
G
AL
V
LWIFG
GDY
--
IDA
A
M
VG
YS
VVALMLL
--
L
R
I
I
S
W
D
DIV
S
NK
A
AWN
VF
F
WLA
S
LI
T
LA
T
GL
N
NT
GFI
S
WF
G
KLLAG
S
L
S
G
Y
SP
TI
----
VMV
A
LI
V
VFY
LL
RYFFAS
A
T
AYT
S
A
LA
P
M
MI
A
A
A
LAM
P
---
E
I
PL
PVF
CL
M
V
GA
A
IG
L
G
S
I
LTPYATGP
S
PI
Y
YG
S
GY
LPTA
DYWRLGAIFG
L
I
-
FLVLL
V
I
T
G
fig|749550.3.peg.980
Escherichia coli MS 200-1 (11-478/487)
LAPLAV
IA
II
A
L
L
P
L
PAGL
ESH
T
W
L
YFAVF
T
G
V
IVGLILEP
V
P
GA
VV
AM
VGI
S
I
IA
I
L
S
PW
LLF
SPEQ
LA
Q
P
G
F
KFT
A
KS
L
S
W
A
V
SGFS
N
S
V
I
WL
I
F
A
AF
M
F
GT
GYE
K
TGLGRRIAL
I
LVKKMG
H
RTL
F
LGYA
V
M
F
S
E
L
I
LAP
V
TPSN
S
AR
G
A
GI
I
Y
PII
R
NLPPL
YQ
S
Q
PNDSS
S
R
S
IG
S
Y
I
MWM
GI
V
A
D
CV
TS
A
I
F
L
TAMAPNLL
L
I
GL
M
KS
A
S
H
A
--
TL
SWG
D
WFL
GM
LP
L
S
I
L
L
V
L
L
V
PWL
A
YVLYPP
I
L
K
SG
D
Q
V
P
R
WA
ET
EL
QA
MGPL
CS
REK
R
M
LGL
M
V
G
AL
V
LWIFG
GDY
--
IDA
A
M
VG
YS
VVALMLL
--
L
R
I
I
S
W
D
DIV
S
NK
A
AWN
VF
F
WLA
S
LI
T
LA
T
GL
N
NT
GFI
S
WF
G
KLLAG
S
L
S
G
Y
SP
TI
----
VMV
A
LI
V
VFY
LL
RYFFAS
A
T
AYT
S
A
LA
P
M
MI
A
A
A
LAM
P
---
E
I
PL
PVF
CL
M
V
GA
A
IG
L
G
S
I
LTPYATGP
S
PI
Y
YG
S
GY
LPTA
DYWRLGAIFG
L
I
-
FLVLL
V
I
T
G
fig|656419.3.peg.4034
Escherichia coli M718 (11-478/487)
LAPLAV
IA
II
A
LIP
V
PAGL
ESH
T
W
L
YFAVF
T
G
V
IVGLILEP
V
P
GA
VV
AM
VGI
S
I
IA
I
L
S
PW
LLF
SPEQ
LA
Q
P
G
F
KFT
A
KS
L
S
W
A
V
SGFS
N
S
V
I
WL
I
F
A
AF
M
F
GT
GYE
K
TGLGRRIAL
I
LVKKMG
H
RTL
F
LGYA
V
M
F
S
E
L
I
LAP
V
TPSN
S
AR
G
A
GI
I
Y
PII
R
NLPPL
YQ
S
Q
PNDSS
S
R
S
IG
S
Y
I
MWM
GI
V
A
D
CV
TS
A
I
F
L
TAMAPNLL
L
I
GL
M
KS
A
S
H
A
--
TL
G
WG
D
WFL
GM
LP
L
S
I
L
L
V
L
L
V
PWL
A
YVLYPP
VL
K
SG
D
Q
V
P
R
WA
ET
EL
QA
MGPL
CS
REK
R
M
LGL
M
V
G
AL
V
LWIFG
GDY
--
IDA
A
M
VG
YS
VVALMLL
--
L
R
I
I
S
W
D
DIV
S
NK
A
AWN
VF
F
WL
S
S
LI
T
LA
T
GL
N
NT
GFI
S
WF
G
KLLAG
S
L
S
G
Y
SP
TM
----
VMV
A
LI
V
VFY
LL
RYFFAS
A
T
AYT
S
A
LA
P
M
MI
A
A
A
LAM
P
---
E
I
PL
PVF
CL
M
V
GA
A
IG
L
G
S
I
LTPYATGP
S
PI
Y
YG
S
GY
LPTA
DYWRLGAIFG
L
I
-
FLVLL
M
I
T
G
fig|749540.3.peg.1340
Escherichia coli MS 146-1 (11-478/487)
LAPLAV
IA
II
A
L
L
P
V
PAGL
ENH
T
W
L
YFAVF
T
G
V
IVGLILEP
V
P
GA
VV
AM
VGI
S
I
IA
I
L
S
PW
LLF
SPEQ
LA
Q
P
G
F
KFT
A
KS
L
S
W
A
V
SGFS
N
S
V
I
WL
I
F
A
AF
M
F
GT
GYE
K
TGLGRRIAL
I
LVKKMG
H
RTL
F
LGYA
V
M
F
S
E
L
I
LAP
V
TPSN
S
AR
G
A
GI
I
Y
PII
R
NLPPL
YQ
S
Q
PNDSS
S
R
S
IG
S
Y
I
MWM
GI
V
A
D
CV
TS
A
I
F
L
TAMAPNLL
L
I
GL
M
KS
A
S
H
A
--
TL
SWG
D
WFL
GM
LP
L
S
I
L
L
V
L
L
V
PWL
A
YVLYPP
VL
K
SG
D
Q
V
P
R
WA
ET
EL
QA
MGP
F
CS
REK
R
M
LGL
M
V
G
AL
V
LWIFG
GDY
--
IDA
A
M
VG
YS
VVALMLL
--
L
R
I
I
S
W
D
DIV
S
NK
A
AWN
VF
F
WLA
S
LI
T
LA
T
GL
N
NT
GFI
S
WF
G
KLLAG
S
L
S
G
Y
SP
TM
----
VMV
A
LI
V
VFY
LL
RYFFAS
A
T
AYT
S
A
LA
P
M
MI
A
A
A
LAM
P
---
E
I
PL
PVF
CL
M
V
GA
A
IG
L
G
S
I
LTPYATGP
S
PI
Y
YG
S
GY
LPTA
DYWRLGAIFG
L
I
-
FLVLL
V
I
T
G
fig|656417.3.peg.3899
Escherichia coli M605 (11-478/487)
LAPLAV
IA
II
A
L
L
P
L
PAGL
ESH
T
W
L
YFAVF
T
G
V
IVGLILEP
V
P
GA
VV
AM
VGI
S
I
IA
I
L
S
PW
LLF
SPEQ
LA
Q
P
G
F
KFT
A
KS
L
S
W
A
V
SGFS
N
S
V
I
WL
I
F
A
AF
M
F
GT
GYE
K
TGLGRRIAL
I
LVKKMG
H
RTL
F
LGYA
V
M
F
S
E
L
I
LAP
V
TPSN
S
AR
G
A
GI
I
Y
PII
R
NLPPL
YQ
S
Q
PNDSS
S
R
S
IG
S
Y
I
MWM
GI
V
A
D
CV
TS
A
I
F
L
TAMAPNLL
L
I
GL
M
KS
A
S
H
A
--
TL
SWG
D
WFL
GM
LP
L
S
I
L
L
V
L
L
V
PWL
A
YVLYPP
VL
K
SG
D
Q
V
P
R
WA
ET
EL
QA
MGPL
CS
REK
R
M
LGL
M
V
G
AL
V
LWIFG
GDY
--
IDA
A
M
VG
YS
VVALMLL
--
L
R
I
I
S
W
D
DIV
S
NK
A
AWN
VF
F
WLA
S
LI
T
LA
T
GL
N
NT
GFI
S
WF
G
KLLAG
S
L
S
G
Y
SP
TI
----
VMV
A
LI
V
VFY
LL
RYFFAS
A
T
AYT
S
A
LA
P
M
MI
A
A
A
LAM
P
---
E
I
PL
PVF
CL
M
V
GA
A
IG
L
G
S
I
LTPYATGP
S
PI
Y
YG
S
GY
LPTA
DYWRLGAIFG
L
I
-
FLVLL
V
I
T
G
fig|525281.3.peg.3593
Escherichia coli 83972 (11-478/487)
LAPLAV
IA
II
A
L
L
P
L
PAGL
ESH
T
W
L
YFAVF
T
G
V
IVGLILEP
V
P
GA
VV
AM
VGI
S
I
IA
I
L
S
PW
LLF
SSEQ
LA
Q
P
G
F
KFT
A
KS
L
S
W
A
V
SGFS
N
S
V
I
WL
I
F
A
AF
M
F
GT
GYE
K
TGLGRRIAL
I
LVKKMG
H
RTL
F
LGYA
V
M
F
S
E
L
I
LAP
V
TPSN
S
AR
G
A
GI
I
Y
PII
R
NLPPL
YQ
S
Q
PNDSS
S
R
S
IG
S
Y
I
MWM
GI
V
A
D
CV
TS
A
I
F
L
TAMAPNLL
L
I
GL
M
KS
A
S
N
A
--
TL
SWG
D
WFL
GM
LP
L
S
I
L
L
V
L
L
V
PWL
A
YVLYPP
I
L
K
SG
D
Q
V
P
R
WA
ET
EL
QA
MGPL
CS
REK
R
M
LGL
M
V
G
AL
V
LWIFG
GDY
--
IDA
A
M
VG
YS
VVALMLL
--
L
R
I
I
C
W
D
DIV
S
NK
A
AWN
VF
F
WLA
S
LI
T
LA
T
GL
N
NT
GFI
S
WF
G
KLLAG
S
L
S
G
Y
SP
TI
----
VMV
A
LI
V
VFY
LL
RYFFAS
A
T
AYT
S
A
LA
P
M
MI
A
A
A
LAM
P
---
E
I
PL
PVF
CL
M
V
GA
A
IG
L
G
S
I
LTPYATGP
S
PI
Y
YG
S
GY
LPTV
DYWRLGAIFG
L
I
-
FLVLL
V
I
T
G
fig|655817.3.peg.3640
Escherichia coli ABU 83972 (11-478/487)
LAPLAV
IA
II
A
L
L
P
L
PAGL
ESH
T
W
L
YFAVF
T
G
V
IVGLILEP
V
P
GA
VV
AM
VGI
S
I
IA
I
L
S
PW
LLF
SSEQ
LA
Q
P
G
F
KFT
A
KS
L
S
W
A
V
SGFS
N
S
V
I
WL
I
F
A
AF
M
F
GT
GYE
K
TGLGRRIAL
I
LVKKMG
H
RTL
F
LGYA
V
M
F
S
E
L
I
LAP
V
TPSN
S
AR
G
A
GI
I
Y
PII
R
NLPPL
YQ
S
Q
PNDSS
S
R
S
IG
S
Y
I
MWM
GI
V
A
D
CV
TS
A
I
F
L
TAMAPNLL
L
I
GL
M
KS
A
S
N
A
--
TL
SWG
D
WFL
GM
LP
L
S
I
L
L
V
L
L
V
PWL
A
YVLYPP
I
L
K
SG
D
Q
V
P
R
WA
ET
EL
QA
MGPL
CS
REK
R
M
LGL
M
V
G
AL
V
LWIFG
GDY
--
IDA
A
M
VG
YS
VVALMLL
--
L
R
I
I
C
W
D
DIV
S
NK
A
AWN
VF
F
WLA
S
LI
T
LA
T
GL
N
NT
GFI
S
WF
G
KLLAG
S
L
S
G
Y
SP
TI
----
VMV
A
LI
V
VFY
LL
RYFFAS
A
T
AYT
S
A
LA
P
M
MI
A
A
A
LAM
P
---
E
I
PL
PVF
CL
M
V
GA
A
IG
L
G
S
I
LTPYATGP
S
PI
Y
YG
S
GY
LPTV
DYWRLGAIFG
L
I
-
FLVLL
V
I
T
G
fig|431946.3.peg.3036
Escherichia coli SE15 (11-478/487)
LAPLAV
IA
II
A
L
L
P
L
PAGL
ESH
T
W
L
YFAVF
T
G
V
IVGLILEP
V
P
GA
VV
AM
VGI
S
I
IA
I
L
S
PW
LLF
SPEQ
LA
Q
P
G
F
KFT
A
KS
L
S
W
A
V
SGFS
N
S
V
I
WL
I
F
A
AF
M
F
GT
GYE
K
TGLGRRIAL
I
LVKKMG
H
RTL
F
LGYA
V
M
F
S
E
L
I
LAP
V
TPSN
S
AR
G
A
GI
I
Y
PII
R
NLPPL
YQ
S
Q
PNDSS
S
R
S
IG
S
Y
I
MWM
GI
V
A
D
CV
TS
A
I
F
L
TAMAPNLL
L
I
GL
M
KS
A
S
H
A
--
M
L
SWG
D
WFL
GM
LP
L
S
I
L
L
V
L
L
V
PWL
A
YVLYPP
VL
K
SG
D
Q
V
P
R
WA
ET
EL
QA
MGPL
CS
REK
R
M
LGL
M
V
G
AL
V
LWIFG
GDY
--
IDA
A
M
VG
YS
VVALMLL
--
L
R
I
I
S
W
D
DIV
S
NK
A
AWN
VF
F
WLA
S
LI
T
LA
T
GL
N
NT
GFI
S
WF
G
KLLAG
S
L
S
G
Y
SP
TI
----
VMV
A
LI
V
VFY
LL
RYFFAS
A
T
AYT
S
A
LA
P
M
MI
A
A
A
LAM
P
---
E
I
PL
PVF
CL
M
V
GA
A
IG
L
G
S
I
LTPYATGP
S
PI
Y
YG
S
GY
LPTA
DYWRLGAIFG
L
I
-
FLVLL
V
I
T
G
fig|753642.3.peg.4899
Escherichia coli NC101 (11-478/487)
LAPLAV
IA
II
A
L
L
P
L
PAGL
ESH
T
W
L
YFAVF
T
G
V
IVGLILEP
V
P
GA
VV
AM
VGI
S
I
IA
I
L
S
PW
LLF
SPEQ
LA
Q
P
G
F
KFT
A
KS
L
S
W
A
V
SGFS
N
S
V
I
WL
I
F
A
AF
M
F
GT
GYE
K
TGLGRRIAL
I
LVKKMG
H
RTL
F
LGYA
V
M
F
S
E
L
I
LAP
V
TPSN
S
AR
G
A
GI
I
Y
PII
R
NLPPL
YQ
S
Q
PNDSS
S
R
S
IG
S
Y
I
MWM
GI
V
A
D
CV
TS
A
I
F
L
TAMAPNLL
L
I
GL
M
KS
A
S
H
A
--
TL
SWG
D
WFL
GM
LP
L
S
I
L
L
V
L
L
V
PWL
A
YVLYPP
I
L
K
SG
D
Q
V
P
R
WA
ET
EL
QA
MGPL
CS
REK
R
M
LGL
M
V
G
AL
V
LWIFG
GDY
--
IDA
A
M
VG
YS
VVALMLL
--
L
R
I
I
S
W
D
DIV
S
NK
A
AWN
VF
F
WLA
S
LI
T
LA
T
GL
N
NT
GFI
S
WF
G
KLLAG
S
L
S
G
Y
SP
TI
----
VMV
A
LI
V
VFY
LL
RYFFAS
A
T
AYT
S
A
LA
P
M
MI
A
A
A
LAM
P
---
E
I
PL
PVF
CL
M
V
GA
A
IG
L
G
S
I
LTPYATGP
S
PI
Y
YG
S
GY
LPTA
DYWRLGAIFG
L
I
-
FLVLL
V
I
T
G
fig|749547.3.peg.4007
Escherichia coli MS 187-1 (11-478/487)
LAPLAV
IA
II
A
L
L
P
V
PAGL
ENH
T
W
L
YFAVF
T
G
V
IVGLILEP
V
P
GA
VV
AM
VGI
S
I
IA
I
L
S
PW
LLF
SPEQ
LA
Q
P
G
F
KFT
A
KS
L
S
W
A
V
SGFS
N
S
V
I
WL
I
F
A
AF
M
F
GT
GYE
K
TGLGRRIAL
I
LVKKMG
H
RTL
F
LGYA
V
M
F
S
E
L
I
LAP
V
TPSN
S
AR
G
A
GI
I
Y
PII
R
NLPPL
YQ
S
Q
PNDSS
S
R
S
IG
S
Y
I
MW
V
GI
V
A
D
CV
TS
A
I
F
L
TAMAPNLL
L
I
GL
M
KS
A
S
H
A
--
TL
SWG
D
WFL
GM
LP
L
S
I
L
L
V
L
L
V
PWL
A
YVLYPP
VL
K
SG
D
Q
V
P
R
WA
ET
EL
QA
MGPL
CS
REK
R
M
LGL
M
V
G
AL
V
LWIFG
GDY
--
IDA
A
M
VG
YS
VVALMLL
--
L
R
I
I
S
W
D
DIV
S
NK
A
AWN
VF
F
WLA
S
LI
T
LA
T
GL
N
NT
GFI
S
WF
G
KLLAG
S
L
S
G
Y
SP
TM
----
VMV
A
LI
V
VFY
LL
RYFFAS
A
T
AYT
S
A
LA
P
M
MI
A
A
A
LAM
P
---
E
I
PL
PVF
CL
M
V
GA
A
IG
L
G
S
I
LTPYATGP
S
PI
Y
YG
S
GY
LPTA
DYWRLGAIFG
L
I
-
FLVLL
V
I
T
G
fig|405955.13.peg.3492
Escherichia coli APEC O1 (11-478/487)
LAPLAV
IA
II
A
L
L
P
L
PAGL
ESH
T
W
L
YFAVF
T
G
V
IVGLILEP
V
P
GA
VV
AM
VGI
S
I
IA
I
L
S
PW
LLF
SPEQ
LA
Q
P
G
F
KFT
A
KS
L
S
W
A
V
SGFS
N
S
V
I
WL
I
F
A
AF
M
F
GT
GYE
K
TGLGRRIAL
I
LVKKMG
H
RTL
F
LGYA
V
M
F
S
E
L
I
LAP
V
TPSN
S
AR
G
A
GI
I
Y
PII
R
NLPPL
YQ
S
Q
PNDSS
S
R
S
IG
S
Y
I
MWM
GI
V
A
D
CV
TS
A
I
F
L
TAMAPNLL
L
I
GL
M
KS
A
S
N
A
--
TL
SWG
D
WFL
GM
LP
L
S
I
L
L
V
L
L
V
PWL
A
YVLYPP
I
L
K
SG
D
Q
V
P
R
WA
ET
EL
QA
MGPL
CS
REK
R
M
LGL
M
V
G
AL
V
LWIFG
GDY
--
IDA
A
M
VG
YS
VVALMLL
--
L
R
I
I
C
W
D
DIV
S
NK
A
AWN
VF
F
WLA
S
LI
T
LA
T
GL
N
NT
GFI
S
WF
G
KLLAG
S
L
S
G
Y
SP
TI
----
VMV
A
LI
V
VFY
LL
RYFFAS
A
T
AYT
S
A
LA
P
M
MI
A
A
A
LAM
P
---
E
I
PL
PVF
CL
M
V
GA
A
IG
L
G
S
I
LTPYATGP
S
PI
Y
YG
S
GY
LPTV
DYWRLGAIFG
L
I
-
FLVLL
V
I
T
G
fig|405955.9.peg.2896
Escherichia coli APEC O1 (11-478/487)
LAPLAV
IA
II
A
L
L
P
L
PAGL
ESH
T
W
L
YFAVF
T
G
V
IVGLILEP
V
P
GA
VV
AM
VGI
S
I
IA
I
L
S
PW
LLF
SPEQ
LA
Q
P
G
F
KFT
A
KS
L
S
W
A
V
SGFS
N
S
V
I
WL
I
F
A
AF
M
F
GT
GYE
K
TGLGRRIAL
I
LVKKMG
H
RTL
F
LGYA
V
M
F
S
E
L
I
LAP
V
TPSN
S
AR
G
A
GI
I
Y
PII
R
NLPPL
YQ
S
Q
PNDSS
S
R
S
IG
S
Y
I
MWM
GI
V
A
D
CV
TS
A
I
F
L
TAMAPNLL
L
I
GL
M
KS
A
S
N
A
--
TL
SWG
D
WFL
GM
LP
L
S
I
L
L
V
L
L
V
PWL
A
YVLYPP
I
L
K
SG
D
Q
V
P
R
WA
ET
EL
QA
MGPL
CS
REK
R
M
LGL
M
V
G
AL
V
LWIFG
GDY
--
IDA
A
M
VG
YS
VVALMLL
--
L
R
I
I
C
W
D
DIV
S
NK
A
AWN
VF
F
WLA
S
LI
T
LA
T
GL
N
NT
GFI
S
WF
G
KLLAG
S
L
S
G
Y
SP
TI
----
VMV
A
LI
V
VFY
LL
RYFFAS
A
T
AYT
S
A
LA
P
M
MI
A
A
A
LAM
P
---
E
I
PL
PVF
CL
M
V
GA
A
IG
L
G
S
I
LTPYATGP
S
PI
Y
YG
S
GY
LPTV
DYWRLGAIFG
L
I
-
FLVLL
V
I
T
G
fig|199310.1.peg.3728
Escherichia coli CFT073 (11-478/487)
LAPLAV
IA
II
A
L
L
P
L
PAGL
ESH
T
W
L
YFAVF
T
G
V
IVGLILEP
V
P
GA
VV
AM
VGI
S
I
IA
I
L
S
PW
LLF
SPEQ
LA
Q
P
G
F
KFT
A
KS
L
S
W
A
V
SGFS
N
S
V
I
WL
I
F
A
AF
M
F
GT
GYE
K
TGLGRRIAL
I
LVKKMG
H
RTL
F
LGYA
V
M
F
S
E
L
I
LAP
V
TPSN
S
AR
G
A
GI
I
Y
PII
R
NLPPL
YQ
S
Q
PNDSS
S
R
S
IG
S
Y
I
MWM
GI
V
A
D
CV
TS
A
I
F
L
TAMAPNLL
L
I
GL
M
KS
A
S
N
A
--
TL
SWG
D
WFL
GM
LP
L
S
I
L
L
V
L
L
V
PWL
A
YVLYPP
I
L
K
SG
D
Q
V
P
R
WA
ET
EL
QA
MGPL
CS
REK
R
M
LGL
M
V
G
AL
V
LWIFG
GDY
--
IDA
A
M
VG
YS
VVALMLL
--
L
R
I
I
C
W
D
DIV
S
NK
A
AWN
VF
F
WLA
S
LI
T
LA
T
GL
N
NT
GFI
S
WF
G
KLLAG
S
L
S
G
Y
SP
TI
----
VMV
A
LI
V
VFY
LL
RYFFAS
A
T
AYT
S
A
LA
P
M
MI
A
A
A
LAM
P
---
E
I
PL
PVF
CL
M
V
GA
A
IG
L
G
S
I
LTPYATGP
S
PI
Y
YG
S
GY
LPTV
DYWRLGAIFG
L
I
-
FLVLL
V
I
T
G
fig|199310.4.peg.3594
Escherichia coli CFT073 (11-478/487)
LAPLAV
IA
II
A
L
L
P
L
PAGL
ESH
T
W
L
YFAVF
T
G
V
IVGLILEP
V
P
GA
VV
AM
VGI
S
I
IA
I
L
S
PW
LLF
SPEQ
LA
Q
P
G
F
KFT
A
KS
L
S
W
A
V
SGFS
N
S
V
I
WL
I
F
A
AF
M
F
GT
GYE
K
TGLGRRIAL
I
LVKKMG
H
RTL
F
LGYA
V
M
F
S
E
L
I
LAP
V
TPSN
S
AR
G
A
GI
I
Y
PII
R
NLPPL
YQ
S
Q
PNDSS
S
R
S
IG
S
Y
I
MWM
GI
V
A
D
CV
TS
A
I
F
L
TAMAPNLL
L
I
GL
M
KS
A
S
N
A
--
TL
SWG
D
WFL
GM
LP
L
S
I
L
L
V
L
L
V
PWL
A
YVLYPP
I
L
K
SG
D
Q
V
P
R
WA
ET
EL
QA
MGPL
CS
REK
R
M
LGL
M
V
G
AL
V
LWIFG
GDY
--
IDA
A
M
VG
YS
VVALMLL
--
L
R
I
I
C
W
D
DIV
S
NK
A
AWN
VF
F
WLA
S
LI
T
LA
T
GL
N
NT
GFI
S
WF
G
KLLAG
S
L
S
G
Y
SP
TI
----
VMV
A
LI
V
VFY
LL
RYFFAS
A
T
AYT
S
A
LA
P
M
MI
A
A
A
LAM
P
---
E
I
PL
PVF
CL
M
V
GA
A
IG
L
G
S
I
LTPYATGP
S
PI
Y
YG
S
GY
LPTV
DYWRLGAIFG
L
I
-
FLVLL
V
I
T
G
fig|714962.3.peg.3531
Escherichia coli IHE3034 (11-478/487)
LAPLAV
IA
II
A
L
L
P
L
PAGL
ESH
T
W
L
YFAVF
T
G
V
IVGLILEP
V
P
GA
VV
AM
VGI
S
I
IA
I
L
S
PW
LLF
SPEQ
LA
Q
P
G
F
KFT
A
KS
L
S
W
A
V
SGFS
N
S
V
I
WL
I
F
A
AF
M
F
GT
GYE
K
TGLGRRIAL
I
LVKKMG
H
RTL
F
LGYA
V
M
F
S
E
L
I
LAP
V
TPSN
S
AR
G
A
GI
I
Y
PII
R
NLPPL
YQ
S
Q
PNDSS
S
R
S
IG
S
Y
I
MWM
GI
V
A
D
CV
TS
A
I
F
L
TAMAPNLL
L
I
GL
M
KS
A
S
N
A
--
TL
SWG
D
WFL
GM
LP
L
S
I
L
L
V
L
L
V
PWL
A
YVLYPP
I
L
K
SG
D
Q
V
P
R
WA
ET
EL
QA
MGPL
CS
REK
R
M
LGL
M
V
G
AL
V
LWIFG
GDY
--
IDA
A
M
VG
YS
VVALMLL
--
L
R
I
I
C
W
D
DIV
S
NK
A
AWN
VF
F
WLA
S
LI
T
LA
T
GL
N
NT
GFI
S
WF
G
KLLAG
S
L
S
G
Y
SP
TI
----
VMV
A
LI
V
VFY
LL
RYFFAS
A
T
AYT
S
A
LA
P
M
MI
A
A
A
LAM
P
---
E
I
PL
PVF
CL
M
V
GA
A
IG
L
G
S
I
LTPYATGP
S
PI
Y
YG
S
GY
LPTV
DYWRLGAIFG
L
I
-
FLVLL
V
I
T
G
fig|749546.3.peg.1858
Escherichia coli MS 185-1 (11-478/487)
LAPLAV
IA
II
A
L
L
P
L
PAGL
ESH
T
W
L
YFAVF
T
G
V
IVGLILEP
V
P
GA
VV
AM
VGI
S
I
IA
I
L
S
PW
LLF
SPEQ
LA
Q
P
G
F
KFT
A
KS
L
S
W
A
V
SGFS
N
S
V
I
WL
I
F
A
AF
M
F
GT
GYE
K
TGLGRRIAL
I
LVKKMG
H
RTL
F
LGYA
V
M
F
S
E
L
I
LAP
V
TPSN
S
AR
G
A
GI
I
Y
PII
R
NLPPL
YQ
S
Q
PNDSS
S
R
S
IG
S
Y
I
MWM
GI
V
A
D
CV
TS
A
I
F
L
TAMAPNLL
L
I
GL
M
KS
A
S
N
A
--
TL
SWG
D
WFL
GM
LP
L
S
I
L
L
V
L
L
V
PWL
A
YVLYPP
I
L
K
SG
D
Q
V
P
R
WA
ET
EL
QA
MGPL
CS
REK
R
M
LGL
M
V
G
AL
V
LWIFG
GDY
--
IDA
A
M
VG
YS
VVALMLL
--
L
R
I
I
C
W
D
DIV
S
NK
A
AWN
VF
F
WLA
S
LI
T
LA
T
GL
N
NT
GFI
S
WF
G
KLLAG
S
L
S
G
Y
SP
TI
----
VMV
A
LI
V
VFY
LL
RYFFAS
A
T
AYT
S
A
LA
P
M
MI
A
A
A
LAM
P
---
E
I
PL
PVF
CL
M
V
GA
A
IG
L
G
S
I
LTPYATGP
S
PI
Y
YG
S
GY
LPTV
DYWRLGAIFG
L
I
-
FLVLL
V
I
T
G
fig|749528.3.peg.448
Escherichia coli MS 45-1 (11-478/487)
LAPLAV
IA
II
A
L
L
P
L
PAGL
ESH
T
W
L
YFAVF
T
G
V
IVGLILEP
V
P
GA
VV
AM
VGI
S
I
IA
I
L
S
PW
LLF
SPEQ
LA
Q
P
G
F
KFT
A
KS
L
S
W
A
V
SGFS
N
S
V
I
WL
I
F
A
AF
M
F
GT
GYE
K
TGLGRRIAL
I
LVKKMG
H
RTL
F
LGYA
V
M
F
S
E
L
I
LAP
V
TPSN
S
AR
G
A
GI
I
Y
PII
R
NLPPL
YQ
S
Q
PNDSS
S
R
S
IG
S
Y
I
MWM
GI
V
A
D
CV
TS
A
I
F
L
TAMAPNLL
L
I
GL
M
KS
A
S
N
A
--
TL
SWG
D
WFL
GM
LP
L
S
I
L
L
V
L
L
V
PWL
A
YVLYPP
I
L
K
SG
D
Q
V
P
R
WA
ET
EL
QA
MGPL
CS
REK
R
M
LGL
M
V
G
AL
V
LWIFG
GDY
--
IDA
A
M
VG
YS
VVALMLL
--
L
R
I
I
C
W
D
DIV
S
NK
A
AWN
VF
F
WLA
S
LI
T
LA
T
GL
N
NT
GFI
S
WF
G
KLLAG
S
L
S
G
Y
SP
TI
----
VMV
A
LI
V
VFY
LL
RYFFAS
A
T
AYT
S
A
LA
P
M
MI
A
A
A
LAM
P
---
E
I
PL
PVF
CL
M
V
GA
A
IG
L
G
S
I
LTPYATGP
S
PI
Y
YG
S
GY
LPTV
DYWRLGAIFG
L
I
-
FLVLL
V
I
T
G
fig|585035.6.peg.3392
Escherichia coli S88 (11-478/487)
LAPLAV
IA
II
A
L
L
P
L
PAGL
ESH
T
W
L
YFAVF
T
G
V
IVGLILEP
V
P
GA
VV
AM
VGI
S
I
IA
I
L
S
PW
LLF
SPEQ
LA
Q
P
G
F
KFT
A
KS
L
S
W
A
V
SGFS
N
S
V
I
WL
I
F
A
AF
M
F
GT
GYE
K
TGLGRRIAL
I
LVKKMG
H
RTL
F
LGYA
V
M
F
S
E
L
I
LAP
V
TPSN
S
AR
G
A
GI
I
Y
PII
R
NLPPL
YQ
S
Q
PNDSS
S
R
S
IG
S
Y
I
MWM
GI
V
A
D
CV
TS
A
I
F
L
TAMAPNLL
L
I
GL
M
KS
A
S
N
A
--
TL
SWG
D
WFL
GM
LP
L
S
I
L
L
V
L
L
V
PWL
A
YVLYPP
I
L
K
SG
D
Q
V
P
R
WA
ET
EL
QA
MGPL
CS
REK
R
M
LGL
M
V
G
AL
V
LWIFG
GDY
--
IDA
A
M
VG
YS
VVALMLL
--
L
R
I
I
C
W
D
DIV
S
NK
A
AWN
VF
F
WLA
S
LI
T
LA
T
GL
N
NT
GFI
S
WF
G
KLLAG
S
L
S
G
Y
SP
TI
----
VMV
A
LI
V
VFY
LL
RYFFAS
A
T
AYT
S
A
LA
P
M
MI
A
A
A
LAM
P
---
E
I
PL
PVF
CL
M
V
GA
A
IG
L
G
S
I
LTPYATGP
S
PI
Y
YG
S
GY
LPTV
DYWRLGAIFG
L
I
-
FLVLL
V
I
T
G
fig|869729.3.peg.208
Escherichia coli UM146 (11-478/487)
LAPLAV
IA
II
A
L
L
P
L
PAGL
ESH
T
W
L
YFAVF
T
G
V
IVGLILEP
V
P
GA
VV
AM
VGI
S
I
IA
I
L
S
PW
LLF
SPEQ
LA
Q
P
G
F
KFT
A
KS
L
S
W
A
V
SGFS
N
S
V
I
WL
I
F
A
AF
M
F
GT
GYE
K
TGLGRRIAL
I
LVKKMG
H
RTL
F
LGYA
V
M
F
S
E
L
I
LAP
V
TPSN
S
AR
G
A
GI
I
Y
PII
R
NLPPL
YQ
S
Q
PNDSS
S
R
S
IG
S
Y
I
MWM
GI
V
A
D
CV
TS
A
I
F
L
TAMAPNLL
L
I
GL
M
KS
A
S
N
A
--
TL
SWG
D
WFL
GM
LP
L
S
I
L
L
V
L
L
V
PWL
A
YVLYPP
I
L
K
SG
D
Q
V
P
R
WA
ET
EL
QA
MGPL
CS
REK
R
M
LGL
M
V
G
AL
V
LWIFG
GDY
--
IDA
A
M
VG
YS
VVALMLL
--
L
R
I
I
C
W
D
DIV
S
NK
A
AWN
VF
F
WLA
S
LI
T
LA
T
GL
N
NT
GFI
S
WF
G
KLLAG
S
L
S
G
Y
SP
TI
----
VMV
A
LI
V
VFY
LL
RYFFAS
A
T
AYT
S
A
LA
P
M
MI
A
A
A
LAM
P
---
E
I
PL
PVF
CL
M
V
GA
A
IG
L
G
S
I
LTPYATGP
S
PI
Y
YG
S
GY
LPTV
DYWRLGAIFG
L
I
-
FLVLL
V
I
T
G
fig|364106.7.peg.3466
Escherichia coli UTI89 (11-478/487)
LAPLAV
IA
II
A
L
L
P
L
PAGL
ESH
T
W
L
YFAVF
T
G
V
IVGLILEP
V
P
GA
VV
AM
VGI
S
I
IA
I
L
S
PW
LLF
SPEQ
LA
Q
P
G
F
KFT
A
KS
L
S
W
A
V
SGFS
N
S
V
I
WL
I
F
A
AF
M
F
GT
GYE
K
TGLGRRIAL
I
LVKKMG
H
RTL
F
LGYA
V
M
F
S
E
L
I
LAP
V
TPSN
S
AR
G
A
GI
I
Y
PII
R
NLPPL
YQ
S
Q
PNDSS
S
R
S
IG
S
Y
I
MWM
GI
V
A
D
CV
TS
A
I
F
L
TAMAPNLL
L
I
GL
M
KS
A
S
N
A
--
TL
SWG
D
WFL
GM
LP
L
S
I
L
L
V
L
L
V
PWL
A
YVLYPP
I
L
K
SG
D
Q
V
P
R
WA
ET
EL
QA
MGPL
CS
REK
R
M
LGL
M
V
G
AL
V
LWIFG
GDY
--
IDA
A
M
VG
YS
VVALMLL
--
L
R
I
I
C
W
D
DIV
S
NK
A
AWN
VF
F
WLA
S
LI
T
LA
T
GL
N
NT
GFI
S
WF
G
KLLAG
S
L
S
G
Y
SP
TI
----
VMV
A
LI
V
VFY
LL
RYFFAS
A
T
AYT
S
A
LA
P
M
MI
A
A
A
LAM
P
---
E
I
PL
PVF
CL
M
V
GA
A
IG
L
G
S
I
LTPYATGP
S
PI
Y
YG
S
GY
LPTV
DYWRLGAIFG
L
I
-
FLVLL
V
I
T
G
fig|364106.8.peg.3467
Escherichia coli UTI89 (11-478/487)
LAPLAV
IA
II
A
L
L
P
L
PAGL
ESH
T
W
L
YFAVF
T
G
V
IVGLILEP
V
P
GA
VV
AM
VGI
S
I
IA
I
L
S
PW
LLF
SPEQ
LA
Q
P
G
F
KFT
A
KS
L
S
W
A
V
SGFS
N
S
V
I
WL
I
F
A
AF
M
F
GT
GYE
K
TGLGRRIAL
I
LVKKMG
H
RTL
F
LGYA
V
M
F
S
E
L
I
LAP
V
TPSN
S
AR
G
A
GI
I
Y
PII
R
NLPPL
YQ
S
Q
PNDSS
S
R
S
IG
S
Y
I
MWM
GI
V
A
D
CV
TS
A
I
F
L
TAMAPNLL
L
I
GL
M
KS
A
S
N
A
--
TL
SWG
D
WFL
GM
LP
L
S
I
L
L
V
L
L
V
PWL
A
YVLYPP
I
L
K
SG
D
Q
V
P
R
WA
ET
EL
QA
MGPL
CS
REK
R
M
LGL
M
V
G
AL
V
LWIFG
GDY
--
IDA
A
M
VG
YS
VVALMLL
--
L
R
I
I
C
W
D
DIV
S
NK
A
AWN
VF
F
WLA
S
LI
T
LA
T
GL
N
NT
GFI
S
WF
G
KLLAG
S
L
S
G
Y
SP
TI
----
VMV
A
LI
V
VFY
LL
RYFFAS
A
T
AYT
S
A
LA
P
M
MI
A
A
A
LAM
P
---
E
I
PL
PVF
CL
M
V
GA
A
IG
L
G
S
I
LTPYATGP
S
PI
Y
YG
S
GY
LPTV
DYWRLGAIFG
L
I
-
FLVLL
V
I
T
G
fig|409438.11.peg.3512
Escherichia coli SE11 (11-478/487)
LAPLAV
IA
II
A
L
L
P
V
PAGL
ENH
T
W
L
YFAVF
T
G
V
IVGLILEP
V
P
GA
VV
AM
VGI
S
I
IA
I
L
S
PW
LLF
SPEQ
LA
Q
P
G
F
KFT
A
KS
L
S
W
A
V
SGFS
N
S
V
I
WL
I
F
A
AF
M
F
GT
GYE
K
TGLGRRIAL
I
LVKKMG
H
RTL
F
LGYA
V
M
F
S
E
L
I
LAP
V
TPSN
S
AR
G
A
GI
I
Y
PII
R
NLPPL
YQ
S
Q
PNDSS
S
R
S
IG
S
Y
I
MWM
GI
V
A
D
CV
TS
A
I
F
L
TAMAPNLL
L
I
GL
M
KS
A
S
H
A
--
TL
SWG
D
WFL
GM
LP
L
S
I
L
L
V
L
L
V
PWL
A
YVLYPP
VL
K
SG
V
Q
V
P
R
WA
ET
EL
QA
MGPL
CS
REK
R
M
LGL
M
V
G
AL
V
LWIFG
GDY
--
IDA
A
M
VG
YS
VVALMLL
--
L
R
I
I
S
W
D
DIV
S
NK
A
AWN
VF
F
WLA
S
LI
T
LA
T
GL
N
NT
GFI
S
WF
G
KLLAG
S
L
S
G
Y
SP
TM
----
VMV
A
LI
V
VFY
LL
RYFFAS
A
T
AYT
S
A
LA
P
M
MI
A
A
A
LAM
P
---
E
I
PL
PVF
CL
M
V
GA
A
IG
L
G
S
I
LTPYATGP
S
PI
Y
YG
S
GY
LPTA
DYWRLGAIFG
L
I
-
FLVLL
V
I
T
G
fig|656379.3.peg.3801
Escherichia coli FVEC1302 (11-478/487)
LAPLAV
IA
II
A
L
L
P
L
PAGL
ESH
T
W
L
YFAVF
T
G
V
IVGLILEP
V
P
GA
VV
AM
VGI
S
I
IA
I
L
S
PL
LLF
SPEQ
LA
Q
P
G
F
KFT
A
KS
L
S
W
A
V
SGFS
N
S
V
I
WL
I
F
A
AF
M
F
GT
GYE
K
TGLGRRIAL
I
LVKKMG
H
RTL
F
LGYA
V
M
F
S
E
L
I
LAP
V
TPSN
S
AR
G
A
GI
I
Y
PII
R
NLPPL
YQ
S
Q
PNDSS
S
R
S
IG
S
Y
I
MWM
GI
V
A
D
CV
TS
A
I
F
L
TAMAPNLL
L
I
GL
M
KS
A
S
H
A
--
TL
SWG
D
WFL
GM
LP
L
S
I
L
L
V
L
L
V
PWL
A
YVLYPP
VL
K
SG
D
Q
V
P
R
WA
ET
EL
QA
MGPL
CS
REK
R
M
LGL
M
V
G
AL
V
LWIFG
GDY
--
IDA
A
M
VG
YS
VVALMLL
--
L
R
I
I
S
W
D
DIV
S
NK
A
AWN
VF
F
WLA
S
LI
T
LA
T
GL
N
NT
GFI
S
WF
G
KLLAG
S
L
S
G
Y
SP
TM
----
VMV
A
LI
V
VFY
LL
RYFFAS
A
T
AYT
S
A
LA
P
M
MI
A
A
A
LAM
P
---
E
I
PL
PVF
CL
M
V
GA
A
IG
L
G
S
I
LTPYATGP
S
PI
Y
YG
S
GY
LPTV
DYWRLGAIFG
L
I
-
FLVLL
V
I
T
G
fig|656380.3.peg.3720
Escherichia coli FVEC1412 (11-478/487)
LAPLAV
IA
II
A
L
L
P
L
PAGL
ESH
T
W
L
YFAVF
T
G
V
IVGLILEP
V
P
GA
VV
AM
VGI
S
I
IA
I
L
S
PL
LLF
SPEQ
LA
Q
P
G
F
KFT
A
KS
L
S
W
A
V
SGFS
N
S
V
I
WL
I
F
A
AF
M
F
GT
GYE
K
TGLGRRIAL
I
LVKKMG
H
RTL
F
LGYA
V
M
F
S
E
L
I
LAP
V
TPSN
S
AR
G
A
GI
I
Y
PII
R
NLPPL
YQ
S
Q
PNDSS
S
R
S
IG
S
Y
I
MWM
GI
V
A
D
CV
TS
A
I
F
L
TAMAPNLL
L
I
GL
M
KS
A
S
H
A
--
TL
SWG
D
WFL
GM
LP
L
S
I
L
L
V
L
L
V
PWL
A
YVLYPP
VL
K
SG
D
Q
V
P
R
WA
ET
EL
QA
MGPL
CS
REK
R
M
LGL
M
V
G
AL
V
LWIFG
GDY
--
IDA
A
M
VG
YS
VVALMLL
--
L
R
I
I
S
W
D
DIV
S
NK
A
AWN
VF
F
WLA
S
LI
T
LA
T
GL
N
NT
GFI
S
WF
G
KLLAG
S
L
S
G
Y
SP
TM
----
VMV
A
LI
V
VFY
LL
RYFFAS
A
T
AYT
S
A
LA
P
M
MI
A
A
A
LAM
P
---
E
I
PL
PVF
CL
M
V
GA
A
IG
L
G
S
I
LTPYATGP
S
PI
Y
YG
S
GY
LPTV
DYWRLGAIFG
L
I
-
FLVLL
V
I
T
G
fig|749549.3.peg.5136
Escherichia coli MS 198-1 (11-478/487)
LAPLAV
IA
II
A
L
L
P
L
PAGL
ESH
T
W
L
YFAVF
T
G
V
IVGLILEP
V
P
GA
VV
AM
VGI
S
I
IA
I
L
S
PL
LLF
SPEQ
LA
Q
P
G
F
KFT
A
KS
L
S
W
A
V
SGFS
N
S
V
I
WL
I
F
A
AF
M
F
GT
GYE
K
TGLGRRIAL
I
LVKKMG
H
RTL
F
LGYA
V
M
F
S
E
L
I
LAP
V
TPSN
S
AR
G
A
GI
I
Y
PII
R
NLPPL
YQ
S
Q
PNDSS
S
R
S
IG
S
Y
I
MWM
GI
V
A
D
CV
TS
A
I
F
L
TAMAPNLL
L
I
GL
M
KS
A
S
H
A
--
TL
SWG
D
WFL
GM
LP
L
S
I
L
L
V
L
L
V
PWL
A
YVLYPP
VL
K
SG
D
Q
V
P
R
WA
ET
EL
QA
MGPL
CS
REK
R
M
LGL
M
V
G
AL
V
LWIFG
GDY
--
IDA
A
M
VG
YS
VVALMLL
--
L
R
I
I
S
W
D
DIV
S
NK
A
AWN
VF
F
WLA
S
LI
T
LA
T
GL
N
NT
GFI
S
WF
G
KLLAG
S
L
S
G
Y
SP
TM
----
VMV
A
LI
V
VFY
LL
RYFFAS
A
T
AYT
S
A
LA
P
M
MI
A
A
A
LAM
P
---
E
I
PL
PVF
CL
M
V
GA
A
IG
L
G
S
I
LTPYATGP
S
PI
Y
YG
S
GY
LPTV
DYWRLGAIFG
L
I
-
FLVLL
V
I
T
G
fig|585056.7.peg.3721
Escherichia coli UMN026 (11-478/487)
LAPLAV
IA
II
A
L
L
P
L
PAGL
ESH
T
W
L
YFAVF
T
G
V
IVGLILEP
V
P
GA
VV
AM
VGI
S
I
IA
I
L
S
PL
LLF
SPEQ
LA
Q
P
G
F
KFT
A
KS
L
S
W
A
V
SGFS
N
S
V
I
WL
I
F
A
AF
M
F
GT
GYE
K
TGLGRRIAL
I
LVKKMG
H
RTL
F
LGYA
V
M
F
S
E
L
I
LAP
V
TPSN
S
AR
G
A
GI
I
Y
PII
R
NLPPL
YQ
S
Q
PNDSS
S
R
S
IG
S
Y
I
MWM
GI
V
A
D
CV
TS
A
I
F
L
TAMAPNLL
L
I
GL
M
KS
A
S
H
A
--
TL
SWG
D
WFL
GM
LP
L
S
I
L
L
V
L
L
V
PWL
A
YVLYPP
VL
K
SG
D
Q
V
P
R
WA
ET
EL
QA
MGPL
CS
REK
R
M
LGL
M
V
G
AL
V
LWIFG
GDY
--
IDA
A
M
VG
YS
VVALMLL
--
L
R
I
I
S
W
D
DIV
S
NK
A
AWN
VF
F
WLA
S
LI
T
LA
T
GL
N
NT
GFI
S
WF
G
KLLAG
S
L
S
G
Y
SP
TM
----
VMV
A
LI
V
VFY
LL
RYFFAS
A
T
AYT
S
A
LA
P
M
MI
A
A
A
LAM
P
---
E
I
PL
PVF
CL
M
V
GA
A
IG
L
G
S
I
LTPYATGP
S
PI
Y
YG
S
GY
LPTV
DYWRLGAIFG
L
I
-
FLVLL
V
I
T
G
fig|585397.7.peg.3727
Escherichia coli ED1a (11-478/487)
LAPLAV
IA
II
A
L
L
P
L
PAGL
ESH
T
W
L
YFAVF
T
G
V
IVGLILEP
V
P
GA
VV
AM
VGI
S
I
IA
I
L
S
PW
LLF
SPEQ
LA
Q
P
G
F
KFT
A
KS
L
S
W
A
V
SGFS
N
S
V
I
WL
I
F
A
AF
M
F
GT
GYE
K
TGLGRRIAL
I
LVKKMG
H
RTL
F
LGYA
V
M
F
S
E
L
I
LAP
V
TPSN
S
AR
G
A
GI
I
Y
PII
R
NLPPL
YQ
S
Q
PNDSS
S
R
S
IG
S
Y
I
MWM
GI
V
A
D
CV
TS
A
I
F
L
TAMAPNLL
L
I
GL
M
KS
A
S
N
A
--
TL
SWG
D
WFL
GM
LP
L
S
I
L
L
V
L
L
V
PWL
A
YVLYP
AI
L
K
SG
D
Q
V
P
R
WA
ET
EL
QA
MGPL
CS
REK
R
M
LGL
M
V
G
AL
V
LWIFG
GDY
--
IDA
A
M
VG
YS
VVALMLL
--
L
R
I
I
C
W
D
DIV
S
NK
A
AWN
VF
F
WLA
S
LI
T
LA
T
GL
N
NT
GFI
S
WF
G
KLLAG
S
L
S
G
Y
SP
TI
----
VMV
A
LI
V
VFY
LL
RYFFAS
A
T
AYT
S
A
LA
P
M
MI
A
A
A
LAM
P
---
E
I
PL
PVF
CL
M
V
GA
A
IG
L
G
S
I
LTPYATGP
S
PI
Y
YG
S
GY
LPTA
DYWRLGAIFG
L
I
-
FLVLL
V
I
T
G
fig|585397.9.peg.3724
Escherichia coli ED1a (11-478/487)
LAPLAV
IA
II
A
L
L
P
L
PAGL
ESH
T
W
L
YFAVF
T
G
V
IVGLILEP
V
P
GA
VV
AM
VGI
S
I
IA
I
L
S
PW
LLF
SPEQ
LA
Q
P
G
F
KFT
A
KS
L
S
W
A
V
SGFS
N
S
V
I
WL
I
F
A
AF
M
F
GT
GYE
K
TGLGRRIAL
I
LVKKMG
H
RTL
F
LGYA
V
M
F
S
E
L
I
LAP
V
TPSN
S
AR
G
A
GI
I
Y
PII
R
NLPPL
YQ
S
Q
PNDSS
S
R
S
IG
S
Y
I
MWM
GI
V
A
D
CV
TS
A
I
F
L
TAMAPNLL
L
I
GL
M
KS
A
S
N
A
--
TL
SWG
D
WFL
GM
LP
L
S
I
L
L
V
L
L
V
PWL
A
YVLYP
AI
L
K
SG
D
Q
V
P
R
WA
ET
EL
QA
MGPL
CS
REK
R
M
LGL
M
V
G
AL
V
LWIFG
GDY
--
IDA
A
M
VG
YS
VVALMLL
--
L
R
I
I
C
W
D
DIV
S
NK
A
AWN
VF
F
WLA
S
LI
T
LA
T
GL
N
NT
GFI
S
WF
G
KLLAG
S
L
S
G
Y
SP
TI
----
VMV
A
LI
V
VFY
LL
RYFFAS
A
T
AYT
S
A
LA
P
M
MI
A
A
A
LAM
P
---
E
I
PL
PVF
CL
M
V
GA
A
IG
L
G
S
I
LTPYATGP
S
PI
Y
YG
S
GY
LPTA
DYWRLGAIFG
L
I
-
FLVLL
V
I
T
G
fig|409438.11.peg.4920
Escherichia coli SE11 (8-479/486)
L
V
P
V
L
L
AL
II
S
Q
L
P
V
P
Q
GL
LPY
S
W
Y
YF
SL
F
V
G
V
IV
A
LI
I
EP
L
P
GA
V
I
GL
L
GI
V
I
GA
V
F
S
PV
F
LF
SPEQ
L
H
S
L
G
V
NTT
L
MA
F
H
W
A
V
SGFS
N
D
T
V
WL
I
F
S
AF
M
F
AL
GYE
K
TGLG
K
RI
S
L
W
LV
R
L
MG
A
RTL
T
LGYA
I
S
F
A
DL
L
LAP
F
TPSNTAR
S
A
G
TI
Y
P
V
I
R
NLP
T
L
YG
S
C
P
H
D
E
S
A
R
K
IG
A
YLMW
T
AV
S
T
T
CV
TS
S
F
F
L
S
A
L
APNLL
S
V
AL
I
EQ
Q
T
G
I
--
L
I
G
W
I
D
WF
I
SL
LP
T
GIIL
WS
V
T
P
L
L
G
Y
Y
LYPP
TE
K
KN
D
Q
V
P
V
WA
KE
Q
L
SQ
MG
R
L
TT
K
E
V
I
L
I
L
L
V
V
A
AL
I
LW
V
GC
SGF
--
ID
PA
I
AS
LV
II
S
LM
I
L
--
T
D
I
I
S
W
D
DIV
N
NK
N
AWNT
F
F
W
F
A
T
L
V
A
LASGL
S
EV
GF
V
R
W
A
G
DQIAG
T
L
S
G
F
G
E
LF
----
TIL
A
L
V
V
L
YF
FL
H
YFFAS
G
T
A
H
V
T
A
L
LP
L
MI
A
V
V
SQM
D
---
G
V
N
V
LAF
S
L
L
L
CG
T
Q
G
I
M
G
V
I
TPYATGP
S
PI
Y
YG
S
GY
IKPS
E
YWRLG
F
V
FG
A
I
Y
FLV
Y
I
A
I
E
YP
W
L
fig|562.376.peg.3931
Escherichia coli WV_060327 (11-478/487)
LAPLAV
IA
II
A
L
L
P
L
PAGL
ESH
T
W
L
YFAVF
T
G
V
IVGLILEP
V
P
GA
VV
AM
VGI
S
I
IA
I
L
S
PW
LLF
SPEQ
LA
Q
P
G
F
KFT
A
KS
L
S
W
A
V
SGFS
N
S
V
I
WL
I
F
A
AF
M
F
GT
GYE
K
TGLGRRIAL
I
LVKKMG
H
RTL
F
LGYA
V
M
F
S
E
L
I
LAP
V
TPSN
S
AR
G
A
GI
I
Y
PII
R
NLPPL
YQ
S
Q
PNDSS
S
R
S
IG
S
Y
I
M
L
M
GI
V
A
D
CV
TS
A
I
F
L
TAMAPNLL
L
I
GL
M
KS
A
S
N
A
--
TL
SWG
D
WFL
GM
LP
L
S
I
L
L
V
L
L
V
PWL
A
YVLYPP
I
L
K
SG
D
Q
V
P
R
WA
ET
EL
QA
MGPL
CS
REK
R
M
LGL
M
V
G
AL
V
LWIFG
GDY
--
IDA
A
M
VG
YS
VVALMLL
--
L
R
I
I
C
W
D
DIV
S
NK
A
AWN
VF
F
WLA
S
LI
T
LA
T
GL
N
NT
GFI
S
WF
G
KLLAG
S
L
S
G
Y
SP
TI
----
VMV
A
LI
V
VFY
LL
RYFFAS
A
T
AYT
S
A
LA
P
M
MI
A
A
A
LAM
P
---
E
I
PL
PVF
CL
M
V
GA
A
IG
L
G
S
I
LTPYATGP
S
PI
Y
YG
S
GY
LPTA
DYWRLGAIFG
L
I
-
FLVLL
V
I
T
G
fig|344601.3.peg.415
Escherichia coli B171 (11-476/487)
LAPLAV
IA
II
A
LIP
V
PAGL
ESH
T
W
L
YFAVF
T
G
V
IVGLILEP
V
P
GA
VV
AM
VGI
S
I
IA
I
L
S
PW
LLF
SPEQ
LA
Q
P
G
F
KFT
A
KS
L
S
W
A
V
SGFS
N
S
V
I
WL
I
F
A
AF
M
F
GT
GYE
K
TGLGRRIAL
I
LVKKMG
H
RTL
F
LGYA
V
M
F
S
E
L
I
LAP
V
TPSN
S
AR
G
A
GI
I
Y
PII
R
NLPPL
YQ
S
Q
PNDSS
S
R
S
IG
S
Y
I
MWM
GI
V
A
D
CV
TS
A
I
F
L
TAMAPNLL
L
I
GL
M
KS
A
S
H
A
--
TL
SWG
D
WFL
GM
LP
L
S
I
L
L
V
L
L
V
PWL
A
YVLYPP
VL
K
SG
D
Q
V
P
R
WA
ET
EL
QA
MGPL
CS
REK
R
M
LGL
M
V
G
AL
V
LWIFG
GDY
--
IDA
A
M
VG
YS
VVALMLL
--
L
R
I
I
S
W
DG
IV
S
NK
A
AWN
VF
F
WLA
S
LI
T
LA
T
GL
N
NT
GFI
S
WF
G
KLLAG
S
L
S
G
Y
SP
TM
----
VMV
A
LI
V
VFY
LL
RYFFAS
A
T
AYT
S
A
LA
P
M
MI
A
A
A
LAM
P
---
E
I
PL
PVF
CL
M
V
GA
A
IG
L
G
S
I
LTPYATGP
S
PI
Y
YG
S
GY
LPTV
DYWRLGAIFG
L
I
-
FLVLL
V
I
fig|344601.5.peg.412
Escherichia coli B171 (11-476/487)
LAPLAV
IA
II
A
LIP
V
PAGL
ESH
T
W
L
YFAVF
T
G
V
IVGLILEP
V
P
GA
VV
AM
VGI
S
I
IA
I
L
S
PW
LLF
SPEQ
LA
Q
P
G
F
KFT
A
KS
L
S
W
A
V
SGFS
N
S
V
I
WL
I
F
A
AF
M
F
GT
GYE
K
TGLGRRIAL
I
LVKKMG
H
RTL
F
LGYA
V
M
F
S
E
L
I
LAP
V
TPSN
S
AR
G
A
GI
I
Y
PII
R
NLPPL
YQ
S
Q
PNDSS
S
R
S
IG
S
Y
I
MWM
GI
V
A
D
CV
TS
A
I
F
L
TAMAPNLL
L
I
GL
M
KS
A
S
H
A
--
TL
SWG
D
WFL
GM
LP
L
S
I
L
L
V
L
L
V
PWL
A
YVLYPP
VL
K
SG
D
Q
V
P
R
WA
ET
EL
QA
MGPL
CS
REK
R
M
LGL
M
V
G
AL
V
LWIFG
GDY
--
IDA
A
M
VG
YS
VVALMLL
--
L
R
I
I
S
W
DG
IV
S
NK
A
AWN
VF
F
WLA
S
LI
T
LA
T
GL
N
NT
GFI
S
WF
G
KLLAG
S
L
S
G
Y
SP
TM
----
VMV
A
LI
V
VFY
LL
RYFFAS
A
T
AYT
S
A
LA
P
M
MI
A
A
A
LAM
P
---
E
I
PL
PVF
CL
M
V
GA
A
IG
L
G
S
I
LTPYATGP
S
PI
Y
YG
S
GY
LPTV
DYWRLGAIFG
L
I
-
FLVLL
V
I
fig|585057.4.peg.1414
Escherichia coli IAI39 (12-466/466)
I
V
AL
A
I
W
F
F
P
V
P
D
GL
TPL
T
W
H
IL
A
I
F
I
T
T
V
V
AF
IL
Q
P
L
P
VG
AI
AL
IA
I
S
F
IM
L
-
-
--
---
----
T-
-
-
-
-
--G
M
MK
T
S
E
A
L
K
GFSS
T
T
V
WL
I
V
A
AF
L
Y
AK
G
F
I
K
TGLGRRIA
Y
L
L
I
R
GF
G
G
S
S
L
R
LGY
T
L
AL
S
D
MII
AP
A
TPSNTAR
A
GGI
L
F
PI
V
R
SV
SNS
FG
S
E
P
D
QG
P
R
-
K
IG
A
YLM
QT
VF
H
S
N
CL
S
S
S
MF
M
TA
S
APN
A
L
I
V
SL
A
AS
T
L
F
V
--
D
ISWG
M
W
T
L
SA
L
V
P
GII
AF
I
T
M
P
LV
I
Y
K
LYPPEIK
KT
P
E
A
K
AL
A
QE
EL
IK
MGP
V
TR
D
E
R
V
T
I
G
I
F
L
L
S
L
L
A
W
ST
S
KWT
-
G
L
DAT
A
V
A
LS
G
V
C
LML
M
--
T
R
I
I
T
W
Q
D
V
Q
S
E
K
G
AW
D
I
L
V
WL
G
V
M
I
C
M
A
DK
L
N
QL
G
L
F
K
WFA
-VTTS
A
L
F
T
G
I
P
WE
--
I
-
TLT
VL
L
I
V
Y
C
YS
H
YFFA
G
S
T
P
H
V
V
AM
YAA
FG
S
V
S
VAA
-
---
G
A
P
P
MMA
A
L
S
L
AF
VTN
L
MS
G
IS
H
Y
G
N
GP
A
V
I
Y
YG
A
GY
VSQR
E
W
WRLG
F
I
VM
L
L
N
I
VI
WF
G
L
G
AV
WW
K
I
L
G
L
W
fig|585057.6.peg.1414
Escherichia coli IAI39 (12-466/466)
I
V
AL
A
I
W
F
F
P
V
P
D
GL
TPL
T
W
H
IL
A
I
F
I
T
T
V
V
AF
IL
Q
P
L
P
VG
AI
AL
IA
I
S
F
IM
L
-
-
--
---
----
T-
-
-
-
-
--G
M
MK
T
S
E
A
L
K
GFSS
T
T
V
WL
I
V
A
AF
L
Y
AK
G
F
I
K
TGLGRRIA
Y
L
L
I
R
GF
G
G
S
S
L
R
LGY
T
L
AL
S
D
MII
AP
A
TPSNTAR
A
GGI
L
F
PI
V
R
SV
SNS
FG
S
E
P
D
QG
P
R
-
K
IG
A
YLM
QT
VF
H
S
N
CL
S
S
S
MF
M
TA
S
APN
A
L
I
V
SL
A
AS
T
L
F
V
--
D
ISWG
M
W
T
L
SA
L
V
P
GII
AF
I
T
M
P
LV
I
Y
K
LYPPEIK
KT
P
E
A
K
AL
A
QE
EL
IK
MGP
V
TR
D
E
R
V
T
I
G
I
F
L
L
S
L
L
A
W
ST
S
KWT
-
G
L
DAT
A
V
A
LS
G
V
C
LML
M
--
T
R
I
I
T
W
Q
D
V
Q
S
E
K
G
AW
D
I
L
V
WL
G
V
M
I
C
M
A
DK
L
N
QL
G
L
F
K
WFA
-VTTS
A
L
F
T
G
I
P
WE
--
I
-
TLT
VL
L
I
V
Y
C
YS
H
YFFA
G
S
T
P
H
V
V
AM
YAA
FG
S
V
S
VAA
-
---
G
A
P
P
MMA
A
L
S
L
AF
VTN
L
MS
G
IS
H
Y
G
N
GP
A
V
I
Y
YG
A
GY
VSQR
E
W
WRLG
F
I
VM
L
L
N
I
VI
WF
G
L
G
AV
WW
K
I
L
G
L
W
fig|749527.3.peg.3502
Escherichia coli MS 21-1 (12-466/466)
I
V
AL
A
I
W
F
F
P
V
P
D
GL
TPL
T
W
H
IL
A
I
F
I
T
T
V
V
AF
IL
Q
P
L
P
VG
AI
AL
IA
I
S
F
IM
L
-
-
--
---
----
T-
-
-
-
-
--G
M
MK
T
S
E
A
L
K
GFSS
T
T
V
WL
I
V
A
AF
L
Y
AK
G
F
I
K
TGLGRRIA
Y
L
L
I
R
GF
G
G
S
S
L
R
LGY
T
L
AL
S
D
MII
AP
A
TPSNTAR
A
GGI
L
F
PI
V
R
SV
SNS
FG
S
E
P
D
QG
P
R
-
K
IG
A
YLM
QT
VF
H
S
N
CL
S
S
S
MF
M
TA
S
APN
A
L
I
V
SL
A
AS
T
L
F
V
--
D
ISWG
M
W
T
L
SA
L
V
P
GII
AF
I
T
M
P
LV
I
Y
K
LYPPEIK
KT
P
E
A
K
AL
A
QE
EL
IK
MGP
V
TR
D
E
R
V
T
I
G
I
F
L
L
S
L
L
A
W
ST
S
KWT
-
G
L
DAT
A
V
A
LS
G
V
C
LML
M
--
T
R
I
I
T
W
Q
D
V
Q
S
E
K
G
AW
D
I
L
V
WL
G
V
M
I
C
M
A
DK
L
N
QL
G
L
F
K
WFA
-VTTS
A
L
F
T
G
I
P
WE
--
I
-
TLT
VL
L
I
V
Y
C
YS
H
YFFA
G
S
T
P
H
V
V
AM
YAA
FG
S
V
S
VAA
-
---
G
A
P
P
MMA
A
L
S
L
AF
VTN
L
MS
G
IS
H
Y
G
N
GP
A
V
I
Y
YG
A
GY
VSQR
E
W
WRLG
F
I
VM
L
L
N
I
VI
WF
G
L
G
AV
WW
K
I
L
G
L
W
fig|550676.3.peg.2013
Escherichia coli B185 (12-466/466)
I
V
AL
A
I
W
F
S
P
V
P
D
GL
TLL
T
W
H
IL
A
I
F
I
T
T
V
V
AF
IL
Q
P
L
P
VG
AI
AL
IA
I
S
F
IM
L
-
-
--
---
----
T-
-
-
-
-
--G
M
MK
T
S
E
A
L
K
GFSS
T
T
V
WL
I
V
A
AF
L
Y
AK
G
F
I
K
TGLGRRIA
Y
L
L
I
R
GF
G
G
S
S
L
R
LGY
T
L
AL
S
D
MII
AP
A
TPSNTAR
A
GGI
L
F
PI
V
R
SV
SNS
FG
S
E
P
D
QG
P
R
-
K
IG
A
YLM
QT
VF
H
S
N
CL
S
S
S
MF
M
TA
S
APN
A
L
I
V
SL
A
AS
T
L
F
V
--
D
ISWG
M
W
T
L
SA
L
V
P
GII
AF
I
T
M
P
LV
I
Y
K
LYPPEIK
KT
P
E
A
K
AL
A
QE
EL
IK
MGP
V
TR
D
E
R
V
T
I
G
I
F
L
L
S
L
L
A
W
ST
S
KWT
-
G
L
DAT
A
V
A
LS
G
V
C
LML
M
--
T
R
I
I
T
W
Q
D
V
Q
S
E
K
G
AW
D
I
L
V
WL
G
V
M
I
C
M
A
DK
L
N
QL
G
L
F
K
WFA
-VTTS
A
L
F
T
G
I
P
WE
--
I
-
TLT
VL
L
I
V
Y
C
YS
H
YFFA
G
S
T
P
H
V
V
AM
YAA
FG
S
V
S
VAA
-
---
G
A
P
P
MMA
A
L
S
L
AF
VTN
L
MS
G
IS
H
Y
G
N
GP
A
V
I
Y
YG
A
GY
VSQR
E
W
WRLG
F
I
VM
L
L
N
I
VI
WF
G
L
G
AV
WW
K
I
L
G
L
W
fig|409438.11.peg.4898
Escherichia coli SE11 (32-486/486)
PAG
V
NEF
AW
R
TVV
I
F
L
A
T
IV
C
I
I
C
K
V
L
P
VG
AI
GV
IA
I
T
V
YA
L
-
-
--
---
----
TG
S
G
G
A
LTA
Q
ES
I
S
Q
A
LS
AM
N
N
T
L
L
WL
I
V
I
AF
M
I
SR
G
FV
K
TGLG
E
RIAL
V
LV
R
L
L
G
K
RTL
G
L
A
Y
G
L
AL
A
DL
L
L
S
P
A
M
PSNTAR
C
GG
V
I
Y
P
V
A
D
S
L
SRS
YG
S
F
P
D
D
D
S
R
Q
R
L
G
T
F
L
I
TC
TG
L
V
N
DI
TS
T
L
F
L
T
G
FTA
NLL
A
V
KL
A
A-
L
Q
G
I
--
S
L
SW
L
N
WF
T
FM
V
L
P
C
I
V
SF
VV
T
P
L
I
V
YVL
V
PP
Q
IK
VT
P
E
A
P
ES
A
LL
R
L
RE
K
G
K
I
TV
P
E
W
L
M
M
G
T
V
L
L
L
L
V
LWI
A
G
SYA
-
G
ID
Q
T
T
T
A
FI
G
L
S
VL
LL
--
S
G
V
L
N
W
E
D
V
K
N
E
K
G
AW
D
TL
I
W
F
S
A
L
L
M
LA
T
Q
L
S
SL
GF
T
D
WF
G
HIIGS
D
V
R
K
I
I
H
GS
NWIF
VLI
I
L
N
V
IY
C
YL
H
YFFAS
G
N
A
IV
A
A
L
YA
V
FL
S
V
G
ISL
-
---
G
V
P
A
IPM
A
L
M
L
SC
CTN
I
SC
S
LT
Q
Y
TH
A
R
GPI
L
F
G
A
GY
IPTS
V
W
W
K
T
G
F
V
MS
I
I
N
L
VI
FF
L
VG
LI
WW
K
V
L
G
L
Y
fig|749548.3.peg.4681
Escherichia coli MS 196-1 (13-475/477)
LA
I
PC
II
G
F
M
P
A
PAGL
SEL
AW
V
L
F
GIY
L
A
A
IVGL
VIK
P
F
P
EP
VV
LL
IAV
A
-
AS
M
-
-
--
---
----
VV
V
G
N
L
SDG
A
FK
T
T
A
V
LSG
Y
SS
G
T
T
WLVF
S
AF
T
L
SA
AFV
T
TGLG
K
RIA
Y
L
L
IG
K
I
G
N
T
TL
G
LGY
V
T
VF
L
DLVLAP
A
TPSNTAR
A
GGIV
L
PII
N
SVAVA
LG
S
E
P
EK
S
P
R
-
R
V
G
H
YLM
MS
IY
M
V
T
KT
TS
Y
MF
F
TAMA
G
N
I
L
A
L
KM
I
ND
I
L
H
L
--
QISWG
G
W
A
L
AA
GL
P
GII
M
LL
V
T
P
LV
I
Y
TM
YPPEIK
KV
D
N
-
K
T
I
A
KA
G
L
AE
L
GP
M
KI
REK
M
LLG
V
F
VLAL
R
G
WIF
S
KSL
-
GV
D
E
S
T
V
A
IV
V
M
A
T
MLL
--
L
G
IV
T
W
E
D
V
V
K
NK
G
G
WNTL
I
W
YG
G
I
I
G
L
S
S
L
L
S
KV
K
F
F
E
W
L
A
EVFKN
N
L
A
F
D
GH
GN
--
V
-
AFF
V
I
I
F
LSI
IV
RYFFAS
G
SAY
I
V
AMLPV
FA
M
L
A
NVS
-
---
G
A
PL
MLT
A
L
A
L
LF
S
NS
Y
GG
M
V
T
H
Y
GGAA
GP
V
I
F
G
V
GY
NDIK
SW
W
LV
GA
VLT
I
L
T
FLV
HI
T
L
G
VW
WW
N
ML
I
GWN
fig|316401.4.peg.903
Escherichia coli ETEC H10407 (13-464/490)
LA
I
PC
II
G
F
M
P
A
PAGL
SEL
AW
V
L
F
GIY
L
A
A
IVGL
VIK
P
F
P
EP
VV
LL
IAV
A
-
AS
M
-
-
--
---
----
VV
V
G
N
L
SDG
A
FK
T
T
A
V
LSG
Y
SS
G
T
T
WLVF
S
AF
T
L
SA
AFV
T
TGLG
K
RIA
Y
L
L
IG
K
I
G
N
T
TL
G
LGY
V
T
VF
L
DLVLAP
A
TPSNTAR
A
GGIV
L
PII
N
SVAVA
LG
S
E
P
EK
S
P
R
-
R
V
G
H
YLM
MS
IY
M
V
T
KT
TS
Y
MF
F
TAMA
G
N
I
L
A
L
KM
I
ND
I
L
H
L
--
QISWG
G
W
A
L
AA
GL
P
GII
M
LL
V
T
P
LV
I
Y
TM
YPPEIK
KV
D
N
-
K
T
I
A
KA
G
L
AE
L
GP
M
KI
REK
M
LLG
V
F
VLAL
L
G
WIF
S
KSL
-
GV
D
E
S
N
V
A
IV
V
M
A
T
MLL
--
L
G
IV
T
W
E
D
V
V
K
NK
G
G
WNTL
I
W
YG
G
I
I
G
L
S
S
L
L
S
KV
K
F
F
E
W
L
A
EVFKN
N
L
A
F
D
GH
GN
--
V
-
AFF
V
I
I
F
LSI
IV
RYFFAS
G
SAY
I
V
AMLPV
FA
M
L
A
NVS
-
---
G
A
PL
MLT
A
L
A
L
LF
S
NS
Y
GG
M
V
T
H
Y
GGAA
GP
V
I
F
G
V
GY
NDIK
SW
W
LV
GA
VLT
I
L
T
FLV
HI
T
L
G
fig|562.371.peg.240
Escherichia coli 1044A (13-475/477)
LA
I
PC
II
G
F
M
P
A
PAGL
SEL
AW
V
L
F
GIY
L
A
A
IVGL
VIK
P
F
P
EP
VV
LL
IAV
A
-
AS
M
-
-
--
---
----
VV
V
G
N
L
SDG
A
FK
T
T
A
V
LSG
Y
SS
G
T
T
WLVF
S
AF
T
L
SA
AFV
T
TGLG
K
RIA
Y
L
L
IG
K
I
G
N
T
TL
G
LGY
V
T
VF
L
DLVLAP
A
TPSNTAR
A
GGIV
L
PII
N
SVAVA
LG
S
E
P
EK
S
P
R
-
R
V
G
H
YLM
MS
IY
M
V
T
KT
TS
Y
MF
F
TAMA
G
N
I
L
A
L
KM
I
ND
I
L
H
L
--
QISWG
G
W
A
L
AA
GL
P
GII
M
LL
V
T
P
LV
I
Y
TM
YPPEIK
KV
D
N
-
K
T
I
A
KA
G
L
AE
L
GP
M
KI
REK
M
LLG
V
F
VLAL
L
G
WIF
S
KSL
-
GV
D
E
S
S
V
A
IV
V
M
A
T
MLL
--
L
G
IV
T
W
E
D
V
V
K
NK
G
G
WNTL
I
W
YG
G
I
I
G
L
S
S
L
L
S
KV
K
F
F
E
W
L
A
EVFKN
N
L
A
F
D
GH
GN
--
V
-
AFF
V
I
I
F
LSI
IV
RYFFAS
G
SAY
I
V
AMLPV
FA
M
L
A
NVS
-
---
G
A
PL
MLT
A
L
A
L
LF
S
NS
Y
GG
M
V
T
H
Y
GGAA
GP
V
I
F
G
V
GY
NDIK
SW
W
LV
GA
VLT
I
L
T
FLV
HI
T
L
G
VW
WW
N
ML
I
GWN
fig|562.373.peg.2950
Escherichia coli 1125A (13-475/477)
LA
I
PC
II
G
F
M
P
A
PAGL
SEL
AW
V
L
F
GIY
L
A
A
IVGL
VIK
P
F
P
EP
VV
LL
IAV
A
-
AS
M
-
-
--
---
----
VV
V
G
N
L
SDG
A
FK
T
T
A
V
LSG
Y
SS
G
T
T
WLVF
S
AF
T
L
SA
AFV
T
TGLG
K
RIA
Y
L
L
IG
K
I
G
N
T
TL
G
LGY
V
T
VF
L
DLVLAP
A
TPSNTAR
A
GGIV
L
PII
N
SVAVA
LG
S
E
P
EK
S
P
R
-
R
V
G
H
YLM
MS
IY
M
V
T
KT
TS
Y
MF
F
TAMA
G
N
I
L
A
L
KM
I
ND
I
L
H
L
--
QISWG
G
W
A
L
AA
GL
P
GII
M
LL
V
T
P
LV
I
Y
TM
YPPEIK
KV
D
N
-
K
T
I
A
KA
G
L
AE
L
GP
M
KI
REK
M
LLG
V
F
VLAL
L
G
WIF
S
KSL
-
GV
D
E
S
S
V
A
IV
V
M
A
T
MLL
--
L
G
IV
T
W
E
D
V
V
K
NK
G
G
WNTL
I
W
YG
G
I
I
G
L
S
S
L
L
S
KV
K
F
F
E
W
L
A
EVFKN
N
L
A
F
D
GH
GN
--
V
-
AFF
V
I
I
F
LSI
IV
RYFFAS
G
SAY
I
V
AMLPV
FA
M
L
A
NVS
-
---
G
A
PL
MLT
A
L
A
L
LF
S
NS
Y
GG
M
V
T
H
Y
GGAA
GP
V
I
F
G
V
GY
NDIK
SW
W
LV
GA
VLT
I
L
T
FLV
HI
T
L
G
VW
WW
N
ML
I
GWN
fig|562.372.peg.1773
Escherichia coli 1212A (13-475/477)
LA
I
PC
II
G
F
M
P
A
PAGL
SEL
AW
V
L
F
GIY
L
A
A
IVGL
VIK
P
F
P
EP
VV
LL
IAV
A
-
AS
M
-
-
--
---
----
VV
V
G
N
L
SDG
A
FK
T
T
A
V
LSG
Y
SS
G
T
T
WLVF
S
AF
T
L
SA
AFV
T
TGLG
K
RIA
Y
L
L
IG
K
I
G
N
T
TL
G
LGY
V
T
VF
L
DLVLAP
A
TPSNTAR
A
GGIV
L
PII
N
SVAVA
LG
S
E
P
EK
S
P
R
-
R
V
G
H
YLM
MS
IY
M
V
T
KT
TS
Y
MF
F
TAMA
G
N
I
L
A
L
KM
I
ND
I
L
H
L
--
QISWG
G
W
A
L
AA
GL
P
GII
M
LL
V
T
P
LV
I
Y
TM
YPPEIK
KV
D
N
-
K
T
I
A
KA
G
L
AE
L
GP
M
KI
REK
M
LLG
V
F
VLAL
L
G
WIF
S
KSL
-
GV
D
E
S
S
V
A
IV
V
M
A
T
MLL
--
L
G
IV
T
W
E
D
V
V
K
NK
G
G
WNTL
I
W
YG
G
I
I
G
L
S
S
L
L
S
KV
K
F
F
E
W
L
A
EVFKN
N
L
A
F
D
GH
GN
--
V
-
AFF
V
I
I
F
LSI
IV
RYFFAS
G
SAY
I
V
AMLPV
FA
M
L
A
NVS
-
---
G
A
PL
MLT
A
L
A
L
LF
S
NS
Y
GG
M
V
T
H
Y
GGAA
GP
V
I
F
G
V
GY
NDIK
SW
W
LV
GA
VLT
I
L
T
FLV
HI
T
L
G
VW
WW
N
ML
I
GWN
fig|562.374.peg.1075
Escherichia coli 536A (13-475/477)
LA
I
PC
II
G
F
M
P
A
PAGL
SEL
AW
V
L
F
GIY
L
A
A
IVGL
VIK
P
F
P
EP
VV
LL
IAV
A
-
AS
M
-
-
--
---
----
VV
V
G
N
L
SDG
A
FK
T
T
A
V
LSG
Y
SS
G
T
T
WLVF
S
AF
T
L
SA
AFV
T
TGLG
K
RIA
Y
L
L
IG
K
I
G
N
T
TL
G
LGY
V
T
VF
L
DLVLAP
A
TPSNTAR
A
GGIV
L
PII
N
SVAVA
LG
S
E
P
EK
S
P
R
-
R
V
G
H
YLM
MS
IY
M
V
T
KT
TS
Y
MF
F
TAMA
G
N
I
L
A
L
KM
I
ND
I
L
H
L
--
QISWG
G
W
A
L
AA
GL
P
GII
M
LL
V
T
P
LV
I
Y
TM
YPPEIK
KV
D
N
-
K
T
I
A
KA
G
L
AE
L
GP
M
KI
REK
M
LLG
V
F
VLAL
L
G
WIF
S
KSL
-
GV
D
E
S
S
V
A
IV
V
M
A
T
MLL
--
L
G
IV
T
W
E
D
V
V
K
NK
G
G
WNTL
I
W
YG
G
I
I
G
L
S
S
L
L
S
KV
K
F
F
E
W
L
A
EVFKN
N
L
A
F
D
GH
GN
--
V
-
AFF
V
I
I
F
LSI
IV
RYFFAS
G
SAY
I
V
AMLPV
FA
M
L
A
NVS
-
---
G
A
PL
MLT
A
L
A
L
LF
S
NS
Y
GG
M
V
T
H
Y
GGAA
GP
V
I
F
G
V
GY
NDIK
SW
W
LV
GA
VLT
I
L
T
FLV
HI
T
L
G
VW
WW
N
ML
I
GWN
fig|83334.1.peg.869
Escherichia coli O157:H7 (13-475/477)
LA
I
PC
II
G
F
M
P
A
PAGL
SEL
AW
V
L
F
GIY
L
A
A
IVGL
VIK
P
F
P
EP
VV
LL
IAV
A
-
AS
M
-
-
--
---
----
VV
V
G
N
L
SDG
A
FK
T
T
A
V
LSG
Y
SS
G
T
T
WLVF
S
AF
T
L
SA
AFV
T
TGLG
K
RIA
Y
L
L
IG
K
I
G
N
T
TL
G
LGY
V
T
VF
L
DLVLAP
A
TPSNTAR
A
GGIV
L
PII
N
SVAVA
LG
S
E
P
EK
S
P
R
-
R
V
G
H
YLM
MS
IY
M
V
T
KT
TS
Y
MF
F
TAMA
G
N
I
L
A
L
KM
I
ND
I
L
H
L
--
QISWG
G
W
A
L
AA
GL
P
GII
M
LL
V
T
P
LV
I
Y
TM
YPPEIK
KV
D
N
-
K
T
I
A
KA
G
L
AE
L
GP
M
KI
REK
M
LLG
V
F
VLAL
L
G
WIF
S
KSL
-
GV
D
E
S
S
V
A
IV
V
M
A
T
MLL
--
L
G
IV
T
W
E
D
V
V
K
NK
G
G
WNTL
I
W
YG
G
I
I
G
L
S
S
L
L
S
KV
K
F
F
E
W
L
A
EVFKN
N
L
A
F
D
GH
GN
--
V
-
AFF
V
I
I
F
LSI
IV
RYFFAS
G
SAY
I
V
AMLPV
FA
M
L
A
NVS
-
---
G
A
PL
MLT
A
L
A
L
LF
S
NS
Y
GG
M
V
T
H
Y
GGAA
GP
V
I
F
G
V
GY
NDIK
SW
W
LV
GA
VLT
I
L
T
FLV
HI
T
L
G
VW
WW
N
ML
I
GWN
fig|155864.1.peg.799
Escherichia coli O157:H7 EDL933 (13-475/477)
LA
I
PC
II
G
F
M
P
A
PAGL
SEL
AW
V
L
F
GIY
L
A
A
IVGL
VIK
P
F
P
EP
VV
LL
IAV
A
-
AS
M
-
-
--
---
----
VV
V
G
N
L
SDG
A
FK
T
T
A
V
LSG
Y
SS
G
T
T
WLVF
S
AF
T
L
SA
AFV
T
TGLG
K
RIA
Y
L
L
IG
K
I
G
N
T
TL
G
LGY
V
T
VF
L
DLVLAP
A
TPSNTAR
A
GGIV
L
PII
N
SVAVA
LG
S
E
P
EK
S
P
R
-
R
V
G
H
YLM
MS
IY
M
V
T
KT
TS
Y
MF
F
TAMA
G
N
I
L
A
L
KM
I
ND
I
L
H
L
--
QISWG
G
W
A
L
AA
GL
P
GII
M
LL
V
T
P
LV
I
Y
TM
YPPEIK
KV
D
N
-
K
T
I
A
KA
G
L
AE
L
GP
M
KI
REK
M
LLG
V
F
VLAL
L
G
WIF
S
KSL
-
GV
D
E
S
S
V
A
IV
V
M
A
T
MLL
--
L
G
IV
T
W
E
D
V
V
K
NK
G
G
WNTL
I
W
YG
G
I
I
G
L
S
S
L
L
S
KV
K
F
F
E
W
L
A
EVFKN
N
L
A
F
D
GH
GN
--
V
-
AFF
V
I
I
F
LSI
IV
RYFFAS
G
SAY
I
V
AMLPV
FA
M
L
A
NVS
-
---
G
A
PL
MLT
A
L
A
L
LF
S
NS
Y
GG
M
V
T
H
Y
GGAA
GP
V
I
F
G
V
GY
NDIK
SW
W
LV
GA
VLT
I
L
T
FLV
HI
T
L
G
VW
WW
N
ML
I
GWN
fig|155864.8.peg.823
Escherichia coli O157:H7 EDL933 (13-475/477)
LA
I
PC
II
G
F
M
P
A
PAGL
SEL
AW
V
L
F
GIY
L
A
A
IVGL
VIK
P
F
P
EP
VV
LL
IAV
A
-
AS
M
-
-
--
---
----
VV
V
G
N
L
SDG
A
FK
T
T
A
V
LSG
Y
SS
G
T
T
WLVF
S
AF
T
L
SA
AFV
T
TGLG
K
RIA
Y
L
L
IG
K
I
G
N
T
TL
G
LGY
V
T
VF
L
DLVLAP
A
TPSNTAR
A
GGIV
L
PII
N
SVAVA
LG
S
E
P
EK
S
P
R
-
R
V
G
H
YLM
MS
IY
M
V
T
KT
TS
Y
MF
F
TAMA
G
N
I
L
A
L
KM
I
ND
I
L
H
L
--
QISWG
G
W
A
L
AA
GL
P
GII
M
LL
V
T
P
LV
I
Y
TM
YPPEIK
KV
D
N
-
K
T
I
A
KA
G
L
AE
L
GP
M
KI
REK
M
LLG
V
F
VLAL
L
G
WIF
S
KSL
-
GV
D
E
S
S
V
A
IV
V
M
A
T
MLL
--
L
G
IV
T
W
E
D
V
V
K
NK
G
G
WNTL
I
W
YG
G
I
I
G
L
S
S
L
L
S
KV
K
F
F
E
W
L
A
EVFKN
N
L
A
F
D
GH
GN
--
V
-
AFF
V
I
I
F
LSI
IV
RYFFAS
G
SAY
I
V
AMLPV
FA
M
L
A
NVS
-
---
G
A
PL
MLT
A
L
A
L
LF
S
NS
Y
GG
M
V
T
H
Y
GGAA
GP
V
I
F
G
V
GY
NDIK
SW
W
LV
GA
VLT
I
L
T
FLV
HI
T
L
G
VW
WW
N
ML
I
GWN
fig|444454.5.peg.5294
Escherichia coli O157:H7 str. EC4024 (13-475/477)
LA
I
PC
II
G
F
M
P
A
PAGL
SEL
AW
V
L
F
GIY
L
A
A
IVGL
VIK
P
F
P
EP
VV
LL
IAV
A
-
AS
M
-
-
--
---
----
VV
V
G
N
L
SDG
A
FK
T
T
A
V
LSG
Y
SS
G
T
T
WLVF
S
AF
T
L
SA
AFV
T
TGLG
K
RIA
Y
L
L
IG
K
I
G
N
T
TL
G
LGY
V
T
VF
L
DLVLAP
A
TPSNTAR
A
GGIV
L
PII
N
SVAVA
LG
S
E
P
EK
S
P
R
-
R
V
G
H
YLM
MS
IY
M
V
T
KT
TS
Y
MF
F
TAMA
G
N
I
L
A
L
KM
I
ND
I
L
H
L
--
QISWG
G
W
A
L
AA
GL
P
GII
M
LL
V
T
P
LV
I
Y
TM
YPPEIK
KV
D
N
-
K
T
I
A
KA
G
L
AE
L
GP
M
KI
REK
M
LLG
V
F
VLAL
L
G
WIF
S
KSL
-
GV
D
E
S
S
V
A
IV
V
M
A
T
MLL
--
L
G
IV
T
W
E
D
V
V
K
NK
G
G
WNTL
I
W
YG
G
I
I
G
L
S
S
L
L
S
KV
K
F
F
E
W
L
A
EVFKN
N
L
A
F
D
GH
GN
--
V
-
AFF
V
I
I
F
LSI
IV
RYFFAS
G
SAY
I
V
AMLPV
FA
M
L
A
NVS
-
---
G
A
PL
MLT
A
L
A
L
LF
S
NS
Y
GG
M
V
T
H
Y
GGAA
GP
V
I
F
G
V
GY
NDIK
SW
W
LV
GA
VLT
I
L
T
FLV
HI
T
L
G
VW
WW
N
ML
I
GWN
fig|444449.5.peg.4230
Escherichia coli O157:H7 str. EC4042 (13-475/477)
LA
I
PC
II
G
F
M
P
A
PAGL
SEL
AW
V
L
F
GIY
L
A
A
IVGL
VIK
P
F
P
EP
VV
LL
IAV
A
-
AS
M
-
-
--
---
----
VV
V
G
N
L
SDG
A
FK
T
T
A
V
LSG
Y
SS
G
T
T
WLVF
S
AF
T
L
SA
AFV
T
TGLG
K
RIA
Y
L
L
IG
K
I
G
N
T
TL
G
LGY
V
T
VF
L
DLVLAP
A
TPSNTAR
A
GGIV
L
PII
N
SVAVA
LG
S
E
P
EK
S
P
R
-
R
V
G
H
YLM
MS
IY
M
V
T
KT
TS
Y
MF
F
TAMA
G
N
I
L
A
L
KM
I
ND
I
L
H
L
--
QISWG
G
W
A
L
AA
GL
P
GII
M
LL
V
T
P
LV
I
Y
TM
YPPEIK
KV
D
N
-
K
T
I
A
KA
G
L
AE
L
GP
M
KI
REK
M
LLG
V
F
VLAL
L
G
WIF
S
KSL
-
GV
D
E
S
S
V
A
IV
V
M
A
T
MLL
--
L
G
IV
T
W
E
D
V
V
K
NK
G
G
WNTL
I
W
YG
G
I
I
G
L
S
S
L
L
S
KV
K
F
F
E
W
L
A
EVFKN
N
L
A
F
D
GH
GN
--
V
-
AFF
V
I
I
F
LSI
IV
RYFFAS
G
SAY
I
V
AMLPV
FA
M
L
A
NVS
-
---
G
A
PL
MLT
A
L
A
L
LF
S
NS
Y
GG
M
V
T
H
Y
GGAA
GP
V
I
F
G
V
GY
NDIK
SW
W
LV
GA
VLT
I
L
T
FLV
HI
T
L
G
VW
WW
N
ML
I
GWN
fig|444448.5.peg.3507
Escherichia coli O157:H7 str. EC4045 (13-475/477)
LA
I
PC
II
G
F
M
P
A
PAGL
SEL
AW
V
L
F
GIY
L
A
A
IVGL
VIK
P
F
P
EP
VV
LL
IAV
A
-
AS
M
-
-
--
---
----
VV
V
G
N
L
SDG
A
FK
T
T
A
V
LSG
Y
SS
G
T
T
WLVF
S
AF
T
L
SA
AFV
T
TGLG
K
RIA
Y
L
L
IG
K
I
G
N
T
TL
G
LGY
V
T
VF
L
DLVLAP
A
TPSNTAR
A
GGIV
L
PII
N
SVAVA
LG
S
E
P
EK
S
P
R
-
R
V
G
H
YLM
MS
IY
M
V
T
KT
TS
Y
MF
F
TAMA
G
N
I
L
A
L
KM
I
ND
I
L
H
L
--
QISWG
G
W
A
L
AA
GL
P
GII
M
LL
V
T
P
LV
I
Y
TM
YPPEIK
KV
D
N
-
K
T
I
A
KA
G
L
AE
L
GP
M
KI
REK
M
LLG
V
F
VLAL
L
G
WIF
S
KSL
-
GV
D
E
S
S
V
A
IV
V
M
A
T
MLL
--
L
G
IV
T
W
E
D
V
V
K
NK
G
G
WNTL
I
W
YG
G
I
I
G
L
S
S
L
L
S
KV
K
F
F
E
W
L
A
EVFKN
N
L
A
F
D
GH
GN
--
V
-
AFF
V
I
I
F
LSI
IV
RYFFAS
G
SAY
I
V
AMLPV
FA
M
L
A
NVS
-
---
G
A
PL
MLT
A
L
A
L
LF
S
NS
Y
GG
M
V
T
H
Y
GGAA
GP
V
I
F
G
V
GY
NDIK
SW
W
LV
GA
VLT
I
L
T
FLV
HI
T
L
G
VW
WW
N
ML
I
GWN
fig|444453.5.peg.849
Escherichia coli O157:H7 str. EC4076 (13-475/477)
LA
I
PC
II
G
F
M
P
A
PAGL
SEL
AW
V
L
F
GIY
L
A
A
IVGL
VIK
P
F
P
EP
VV
LL
IAV
A
-
AS
M
-
-
--
---
----
VV
V
G
N
L
SDG
A
FK
T
T
A
V
LSG
Y
SS
G
T
T
WLVF
S
AF
T
L
SA
AFV
T
TGLG
K
RIA
Y
L
L
IG
K
I
G
N
T
TL
G
LGY
V
T
VF
L
DLVLAP
A
TPSNTAR
A
GGIV
L
PII
N
SVAVA
LG
S
E
P
EK
S
P
R
-
R
V
G
H
YLM
MS
IY
M
V
T
KT
TS
Y
MF
F
TAMA
G
N
I
L
A
L
KM
I
ND
I
L
H
L
--
QISWG
G
W
A
L
AA
GL
P
GII
M
LL
V
T
P
LV
I
Y
TM
YPPEIK
KV
D
N
-
K
T
I
A
KA
G
L
AE
L
GP
M
KI
REK
M
LLG
V
F
VLAL
L
G
WIF
S
KSL
-
GV
D
E
S
S
V
A
IV
V
M
A
T
MLL
--
L
G
IV
T
W
E
D
V
V
K
NK
G
G
WNTL
I
W
YG
G
I
I
G
L
S
S
L
L
S
KV
K
F
F
E
W
L
A
EVFKN
N
L
A
F
D
GH
GN
--
V
-
AFF
V
I
I
F
LSI
IV
RYFFAS
G
SAY
I
V
AMLPV
FA
M
L
A
NVS
-
---
G
A
PL
MLT
A
L
A
L
LF
S
NS
Y
GG
M
V
T
H
Y
GGAA
GP
V
I
F
G
V
GY
NDIK
SW
W
LV
GA
VLT
I
L
T
FLV
HI
T
L
G
VW
WW
N
ML
I
GWN
fig|444452.5.peg.3238
Escherichia coli O157:H7 str. EC4113 (13-475/477)
LA
I
PC
II
G
F
M
P
A
PAGL
SEL
AW
V
L
F
GIY
L
A
A
IVGL
VIK
P
F
P
EP
VV
LL
IAV
A
-
AS
M
-
-
--
---
----
VV
V
G
N
L
SDG
A
FK
T
T
A
V
LSG
Y
SS
G
T
T
WLVF
S
AF
T
L
SA
AFV
T
TGLG
K
RIA
Y
L
L
IG
K
I
G
N
T
TL
G
LGY
V
T
VF
L
DLVLAP
A
TPSNTAR
A
GGIV
L
PII
N
SVAVA
LG
S
E
P
EK
S
P
R
-
R
V
G
H
YLM
MS
IY
M
V
T
KT
TS
Y
MF
F
TAMA
G
N
I
L
A
L
KM
I
ND
I
L
H
L
--
QISWG
G
W
A
L
AA
GL
P
GII
M
LL
V
T
P
LV
I
Y
TM
YPPEIK
KV
D
N
-
K
T
I
A
KA
G
L
AE
L
GP
M
KI
REK
M
LLG
V
F
VLAL
L
G
WIF
S
KSL
-
GV
D
E
S
S
V
A
IV
V
M
A
T
MLL
--
L
G
IV
T
W
E
D
V
V
K
NK
G
G
WNTL
I
W
YG
G
I
I
G
L
S
S
L
L
S
KV
K
F
F
E
W
L
A
EVFKN
N
L
A
F
D
GH
GN
--
V
-
AFF
V
I
I
F
LSI
IV
RYFFAS
G
SAY
I
V
AMLPV
FA
M
L
A
NVS
-
---
G
A
PL
MLT
A
L
A
L
LF
S
NS
Y
GG
M
V
T
H
Y
GGAA
GP
V
I
F
G
V
GY
NDIK
SW
W
LV
GA
VLT
I
L
T
FLV
HI
T
L
G
VW
WW
N
ML
I
GWN
fig|444450.8.peg.964
Escherichia coli O157:H7 str. EC4115 (13-475/477)
LA
I
PC
II
G
F
M
P
A
PAGL
SEL
AW
V
L
F
GIY
L
A
A
IVGL
VIK
P
F
P
EP
VV
LL
IAV
A
-
AS
M
-
-
--
---
----
VV
V
G
N
L
SDG
A
FK
T
T
A
V
LSG
Y
SS
G
T
T
WLVF
S
AF
T
L
SA
AFV
T
TGLG
K
RIA
Y
L
L
IG
K
I
G
N
T
TL
G
LGY
V
T
VF
L
DLVLAP
A
TPSNTAR
A
GGIV
L
PII
N
SVAVA
LG
S
E
P
EK
S
P
R
-
R
V
G
H
YLM
MS
IY
M
V
T
KT
TS
Y
MF
F
TAMA
G
N
I
L
A
L
KM
I
ND
I
L
H
L
--
QISWG
G
W
A
L
AA
GL
P
GII
M
LL
V
T
P
LV
I
Y
TM
YPPEIK
KV
D
N
-
K
T
I
A
KA
G
L
AE
L
GP
M
KI
REK
M
LLG
V
F
VLAL
L
G
WIF
S
KSL
-
GV
D
E
S
S
V
A
IV
V
M
A
T
MLL
--
L
G
IV
T
W
E
D
V
V
K
NK
G
G
WNTL
I
W
YG
G
I
I
G
L
S
S
L
L
S
KV
K
F
F
E
W
L
A
EVFKN
N
L
A
F
D
GH
GN
--
V
-
AFF
V
I
I
F
LSI
IV
RYFFAS
G
SAY
I
V
AMLPV
FA
M
L
A
NVS
-
---
G
A
PL
MLT
A
L
A
L
LF
S
NS
Y
GG
M
V
T
H
Y
GGAA
GP
V
I
F
G
V
GY
NDIK
SW
W
LV
GA
VLT
I
L
T
FLV
HI
T
L
G
VW
WW
N
ML
I
GWN
fig|444451.5.peg.3986
Escherichia coli O157:H7 str. EC4196 (13-475/477)
LA
I
PC
II
G
F
M
P
A
PAGL
SEL
AW
V
L
F
GIY
L
A
A
IVGL
VIK
P
F
P
EP
VV
LL
IAV
A
-
AS
M
-
-
--
---
----
VV
V
G
N
L
SDG
A
FK
T
T
A
V
LSG
Y
SS
G
T
T
WLVF
S
AF
T
L
SA
AFV
T
TGLG
K
RIA
Y
L
L
IG
K
I
G
N
T
TL
G
LGY
V
T
VF
L
DLVLAP
A
TPSNTAR
A
GGIV
L
PII
N
SVAVA
LG
S
E
P
EK
S
P
R
-
R
V
G
H
YLM
MS
IY
M
V
T
KT
TS
Y
MF
F
TAMA
G
N
I
L
A
L
KM
I
ND
I
L
H
L
--
QISWG
G
W
A
L
AA
GL
P
GII
M
LL
V
T
P
LV
I
Y
TM
YPPEIK
KV
D
N
-
K
T
I
A
KA
G
L
AE
L
GP
M
KI
REK
M
LLG
V
F
VLAL
L
G
WIF
S
KSL
-
GV
D
E
S
S
V
A
IV
V
M
A
T
MLL
--
L
G
IV
T
W
E
D
V
V
K
NK
G
G
WNTL
I
W
YG
G
I
I
G
L
S
S
L
L
S
KV
K
F
F
E
W
L
A
EVFKN
N
L
A
F
D
GH
GN
--
V
-
AFF
V
I
I
F
LSI
IV
RYFFAS
G
SAY
I
V
AMLPV
FA
M
L
A
NVS
-
---
G
A
PL
MLT
A
L
A
L
LF
S
NS
Y
GG
M
V
T
H
Y
GGAA
GP
V
I
F
G
V
GY
NDIK
SW
W
LV
GA
VLT
I
L
T
FLV
HI
T
L
G
VW
WW
N
ML
I
GWN
fig|444447.5.peg.3691
Escherichia coli O157:H7 str. EC4206 (13-475/477)
LA
I
PC
II
G
F
M
P
A
PAGL
SEL
AW
V
L
F
GIY
L
A
A
IVGL
VIK
P
F
P
EP
VV
LL
IAV
A
-
AS
M
-
-
--
---
----
VV
V
G
N
L
SDG
A
FK
T
T
A
V
LSG
Y
SS
G
T
T
WLVF
S
AF
T
L
SA
AFV
T
TGLG
K
RIA
Y
L
L
IG
K
I
G
N
T
TL
G
LGY
V
T
VF
L
DLVLAP
A
TPSNTAR
A
GGIV
L
PII
N
SVAVA
LG
S
E
P
EK
S
P
R
-
R
V
G
H
YLM
MS
IY
M
V
T
KT
TS
Y
MF
F
TAMA
G
N
I
L
A
L
KM
I
ND
I
L
H
L
--
QISWG
G
W
A
L
AA
GL
P
GII
M
LL
V
T
P
LV
I
Y
TM
YPPEIK
KV
D
N
-
K
T
I
A
KA
G
L
AE
L
GP
M
KI
REK
M
LLG
V
F
VLAL
L
G
WIF
S
KSL
-
GV
D
E
S
S
V
A
IV
V
M
A
T
MLL
--
L
G
IV
T
W
E
D
V
V
K
NK
G
G
WNTL
I
W
YG
G
I
I
G
L
S
S
L
L
S
KV
K
F
F
E
W
L
A
EVFKN
N
L
A
F
D
GH
GN
--
V
-
AFF
V
I
I
F
LSI
IV
RYFFAS
G
SAY
I
V
AMLPV
FA
M
L
A
NVS
-
---
G
A
PL
MLT
A
L
A
L
LF
S
NS
Y
GG
M
V
T
H
Y
GGAA
GP
V
I
F
G
V
GY
NDIK
SW
W
LV
GA
VLT
I
L
T
FLV
HI
T
L
G
VW
WW
N
ML
I
GWN
fig|478004.5.peg.3755
Escherichia coli O157:H7 str. EC4401 (13-475/477)
LA
I
PC
II
G
F
M
P
A
PAGL
SEL
AW
V
L
F
GIY
L
A
A
IVGL
VIK
P
F
P
EP
VV
LL
IAV
A
-
AS
M
-
-
--
---
----
VV
V
G
N
L
SDG
A
FK
T
T
A
V
LSG
Y
SS
G
T
T
WLVF
S
AF
T
L
SA
AFV
T
TGLG
K
RIA
Y
L
L
IG
K
I
G
N
T
TL
G
LGY
V
T
VF
L
DLVLAP
A
TPSNTAR
A
GGIV
L
PII
N
SVAVA
LG
S
E
P
EK
S
P
R
-
R
V
G
H
YLM
MS
IY
M
V
T
KT
TS
Y
MF
F
TAMA
G
N
I
L
A
L
KM
I
ND
I
L
H
L
--
QISWG
G
W
A
L
AA
GL
P
GII
M
LL
V
T
P
LV
I
Y
TM
YPPEIK
KV
D
N
-
K
T
I
A
KA
G
L
AE
L
GP
M
KI
REK
M
LLG
V
F
VLAL
L
G
WIF
S
KSL
-
GV
D
E
S
S
V
A
IV
V
M
A
T
MLL
--
L
G
IV
T
W
E
D
V
V
K
NK
G
G
WNTL
I
W
YG
G
I
I
G
L
S
S
L
L
S
KV
K
F
F
E
W
L
A
EVFKN
N
L
A
F
D
GH
GN
--
V
-
AFF
V
I
I
F
LSI
IV
RYFFAS
G
SAY
I
V
AMLPV
FA
M
L
A
NVS
-
---
G
A
PL
MLT
A
L
A
L
LF
S
NS
Y
GG
M
V
T
H
Y
GGAA
GP
V
I
F
G
V
GY
NDIK
SW
W
LV
GA
VLT
I
L
T
FLV
HI
T
L
G
VW
WW
N
ML
I
GWN
fig|478007.5.peg.3457
Escherichia coli O157:H7 str. EC508 (13-475/477)
LA
I
PC
II
G
F
M
P
A
PAGL
SEL
AW
V
L
F
GIY
L
A
A
IVGL
VIK
P
F
P
EP
VV
LL
IAV
A
-
AS
M
-
-
--
---
----
VV
V
G
N
L
SDG
A
FK
T
T
A
V
LSG
Y
SS
G
T
T
WLVF
S
AF
T
L
SA
AFV
T
TGLG
K
RIA
Y
L
L
IG
K
I
G
N
T
TL
G
LGY
V
T
VF
L
DLVLAP
A
TPSNTAR
A
GGIV
L
PII
N
SVAVA
LG
S
E
P
EK
S
P
R
-
R
V
G
H
YLM
MS
IY
M
V
T
KT
TS
Y
MF
F
TAMA
G
N
I
L
A
L
KM
I
ND
I
L
H
L
--
QISWG
G
W
A
L
AA
GL
P
GII
M
LL
V
T
P
LV
I
Y
TM
YPPEIK
KV
D
N
-
K
T
I
A
KA
G
L
AE
L
GP
M
KI
REK
M
LLG
V
F
VLAL
L
G
WIF
S
KSL
-
GV
D
E
S
S
V
A
IV
V
M
A
T
MLL
--
L
G
IV
T
W
E
D
V
V
K
NK
G
G
WNTL
I
W
YG
G
I
I
G
L
S
S
L
L
S
KV
K
F
F
E
W
L
A
EVFKN
N
L
A
F
D
GH
GN
--
V
-
AFF
V
I
I
F
LSI
IV
RYFFAS
G
SAY
I
V
AMLPV
FA
M
L
A
NVS
-
---
G
A
PL
MLT
A
L
A
L
LF
S
NS
Y
GG
M
V
T
H
Y
GGAA
GP
V
I
F
G
V
GY
NDIK
SW
W
LV
GA
VLT
I
L
T
FLV
HI
T
L
G
VW
WW
N
ML
I
GWN
fig|478008.5.peg.2194
Escherichia coli O157:H7 str. EC869 (13-475/477)
LA
I
PC
II
G
F
M
P
A
PAGL
SEL
AW
V
L
F
GIY
L
A
A
IVGL
VIK
P
F
P
EP
VV
LL
IAV
A
-
AS
M
-
-
--
---
----
VV
V
G
N
L
SDG
A
FK
T
T
A
V
LSG
Y
SS
G
T
T
WLVF
S
AF
T
L
SA
AFV
T
TGLG
K
RIA
Y
L
L
IG
K
I
G
N
T
TL
G
LGY
V
T
VF
L
DLVLAP
A
TPSNTAR
A
GGIV
L
PII
N
SVAVA
LG
S
E
P
EK
S
P
R
-
R
V
G
H
YLM
MS
IY
M
V
T
KT
TS
Y
MF
F
TAMA
G
N
I
L
A
L
KM
I
ND
I
L
H
L
--
QISWG
G
W
A
L
AA
GL
P
GII
M
LL
V
T
P
LV
I
Y
TM
YPPEIK
KV
D
N
-
K
T
I
A
KA
G
L
AE
L
GP
M
KI
REK
M
LLG
V
F
VLAL
L
G
WIF
S
KSL
-
GV
D
E
S
S
V
A
IV
V
M
A
T
MLL
--
L
G
IV
T
W
E
D
V
V
K
NK
G
G
WNTL
I
W
YG
G
I
I
G
L
S
S
L
L
S
KV
K
F
F
E
W
L
A
EVFKN
N
L
A
F
D
GH
GN
--
V
-
AFF
V
I
I
F
LSI
IV
RYFFAS
G
SAY
I
V
AMLPV
FA
M
L
A
NVS
-
---
G
A
PL
MLT
A
L
A
L
LF
S
NS
Y
GG
M
V
T
H
Y
GGAA
GP
V
I
F
G
V
GY
NDIK
SW
W
LV
GA
VLT
I
L
T
FLV
HI
T
L
G
VW
WW
N
ML
I
GWN
fig|637388.3.peg.1552
Escherichia coli O157:H7 str. FRIK2000 (13-475/477)
LA
I
PC
II
G
F
M
P
A
PAGL
SEL
AW
V
L
F
GIY
L
A
A
IVGL
VIK
P
F
P
EP
VV
LL
IAV
A
-
AS
M
-
-
--
---
----
VV
V
G
N
L
SDG
A
FK
T
T
A
V
LSG
Y
SS
G
T
T
WLVF
S
AF
T
L
SA
AFV
T
TGLG
K
RIA
Y
L
L
IG
K
I
G
N
T
TL
G
LGY
V
T
VF
L
DLVLAP
A
TPSNTAR
A
GGIV
L
PII
N
SVAVA
LG
S
E
P
EK
S
P
R
-
R
V
G
H
YLM
MS
IY
M
V
T
KT
TS
Y
MF
F
TAMA
G
N
I
L
A
L
KM
I
ND
I
L
H
L
--
QISWG
G
W
A
L
AA
GL
P
GII
M
LL
V
T
P
LV
I
Y
TM
YPPEIK
KV
D
N
-
K
T
I
A
KA
G
L
AE
L
GP
M
KI
REK
M
LLG
V
F
VLAL
L
G
WIF
S
KSL
-
GV
D
E
S
S
V
A
IV
V
M
A
T
MLL
--
L
G
IV
T
W
E
D
V
V
K
NK
G
G
WNTL
I
W
YG
G
I
I
G
L
S
S
L
L
S
KV
K
F
F
E
W
L
A
EVFKN
N
L
A
F
D
GH
GN
--
V
-
AFF
V
I
I
F
LSI
IV
RYFFAS
G
SAY
I
V
AMLPV
FA
M
L
A
NVS
-
---
G
A
PL
MLT
A
L
A
L
LF
S
NS
Y
GG
M
V
T
H
Y
GGAA
GP
V
I
F
G
V
GY
NDIK
SW
W
LV
GA
VLT
I
L
T
FLV
HI
T
L
G
VW
WW
N
ML
I
GWN
fig|570506.3.peg.364
Escherichia coli O157:H7 str. FRIK966 (13-475/477)
LA
I
PC
II
G
F
M
P
A
PAGL
SEL
AW
V
L
F
GIY
L
A
A
IVGL
VIK
P
F
P
EP
VV
LL
IAV
A
-
AS
M
-
-
--
---
----
VV
V
G
N
L
SDG
A
FK
T
T
A
V
LSG
Y
SS
G
T
T
WLVF
S
AF
T
L
SA
AFV
T
TGLG
K
RIA
Y
L
L
IG
K
I
G
N
T
TL
G
LGY
V
T
VF
L
DLVLAP
A
TPSNTAR
A
GGIV
L
PII
N
SVAVA
LG
S
E
P
EK
S
P
R
-
R
V
G
H
YLM
MS
IY
M
V
T
KT
TS
Y
MF
F
TAMA
G
N
I
L
A
L
KM
I
ND
I
L
H
L
--
QISWG
G
W
A
L
AA
GL
P
GII
M
LL
V
T
P
LV
I
Y
TM
YPPEIK
KV
D
N
-
K
T
I
A
KA
G
L
AE
L
GP
M
KI
REK
M
LLG
V
F
VLAL
L
G
WIF
S
KSL
-
GV
D
E
S
S
V
A
IV
V
M
A
T
MLL
--
L
G
IV
T
W
E
D
V
V
K
NK
G
G
WNTL
I
W
YG
G
I
I
G
L
S
S
L
L
S
KV
K
F
F
E
W
L
A
EVFKN
N
L
A
F
D
GH
GN
--
V
-
AFF
V
I
I
F
LSI
IV
RYFFAS
G
SAY
I
V
AMLPV
FA
M
L
A
NVS
-
---
G
A
PL
MLT
A
L
A
L
LF
S
NS
Y
GG
M
V
T
H
Y
GGAA
GP
V
I
F
G
V
GY
NDIK
SW
W
LV
GA
VLT
I
L
T
FLV
HI
T
L
G
VW
WW
N
ML
I
GWN
fig|386585.9.peg.919
Escherichia coli O157:H7 str. Sakai (13-475/477)
LA
I
PC
II
G
F
M
P
A
PAGL
SEL
AW
V
L
F
GIY
L
A
A
IVGL
VIK
P
F
P
EP
VV
LL
IAV
A
-
AS
M
-
-
--
---
----
VV
V
G
N
L
SDG
A
FK
T
T
A
V
LSG
Y
SS
G
T
T
WLVF
S
AF
T
L
SA
AFV
T
TGLG
K
RIA
Y
L
L
IG
K
I
G
N
T
TL
G
LGY
V
T
VF
L
DLVLAP
A
TPSNTAR
A
GGIV
L
PII
N
SVAVA
LG
S
E
P
EK
S
P
R
-
R
V
G
H
YLM
MS
IY
M
V
T
KT
TS
Y
MF
F
TAMA
G
N
I
L
A
L
KM
I
ND
I
L
H
L
--
QISWG
G
W
A
L
AA
GL
P
GII
M
LL
V
T
P
LV
I
Y
TM
YPPEIK
KV
D
N
-
K
T
I
A
KA
G
L
AE
L
GP
M
KI
REK
M
LLG
V
F
VLAL
L
G
WIF
S
KSL
-
GV
D
E
S
S
V
A
IV
V
M
A
T
MLL
--
L
G
IV
T
W
E
D
V
V
K
NK
G
G
WNTL
I
W
YG
G
I
I
G
L
S
S
L
L
S
KV
K
F
F
E
W
L
A
EVFKN
N
L
A
F
D
GH
GN
--
V
-
AFF
V
I
I
F
LSI
IV
RYFFAS
G
SAY
I
V
AMLPV
FA
M
L
A
NVS
-
---
G
A
PL
MLT
A
L
A
L
LF
S
NS
Y
GG
M
V
T
H
Y
GGAA
GP
V
I
F
G
V
GY
NDIK
SW
W
LV
GA
VLT
I
L
T
FLV
HI
T
L
G
VW
WW
N
ML
I
GWN
fig|544404.4.peg.830
Escherichia coli O157:H7 str. TW14359 (13-475/477)
LA
I
PC
II
G
F
M
P
A
PAGL
SEL
AW
V
L
F
GIY
L
A
A
IVGL
VIK
P
F
P
EP
VV
LL
IAV
A
-
AS
M
-
-
--
---
----
VV
V
G
N
L
SDG
A
FK
T
T
A
V
LSG
Y
SS
G
T
T
WLVF
S
AF
T
L
SA
AFV
T
TGLG
K
RIA
Y
L
L
IG
K
I
G
N
T
TL
G
LGY
V
T
VF
L
DLVLAP
A
TPSNTAR
A
GGIV
L
PII
N
SVAVA
LG
S
E
P
EK
S
P
R
-
R
V
G
H
YLM
MS
IY
M
V
T
KT
TS
Y
MF
F
TAMA
G
N
I
L
A
L
KM
I
ND
I
L
H
L
--
QISWG
G
W
A
L
AA
GL
P
GII
M
LL
V
T
P
LV
I
Y
TM
YPPEIK
KV
D
N
-
K
T
I
A
KA
G
L
AE
L
GP
M
KI
REK
M
LLG
V
F
VLAL
L
G
WIF
S
KSL
-
GV
D
E
S
S
V
A
IV
V
M
A
T
MLL
--
L
G
IV
T
W
E
D
V
V
K
NK
G
G
WNTL
I
W
YG
G
I
I
G
L
S
S
L
L
S
KV
K
F
F
E
W
L
A
EVFKN
N
L
A
F
D
GH
GN
--
V
-
AFF
V
I
I
F
LSI
IV
RYFFAS
G
SAY
I
V
AMLPV
FA
M
L
A
NVS
-
---
G
A
PL
MLT
A
L
A
L
LF
S
NS
Y
GG
M
V
T
H
Y
GGAA
GP
V
I
F
G
V
GY
NDIK
SW
W
LV
GA
VLT
I
L
T
FLV
HI
T
L
G
VW
WW
N
ML
I
GWN
fig|701177.3.peg.926
Escherichia coli O55:H7 str. CB9615 (13-475/477)
LA
I
PC
II
G
F
M
P
A
PAGL
SEL
AW
V
L
F
GIY
L
A
A
IVGL
VIK
P
F
P
EP
VV
LL
IAV
A
-
AS
M
-
-
--
---
----
VV
V
G
N
L
SDG
A
FK
T
T
A
V
LSG
Y
SS
G
T
T
WLVF
S
AF
T
L
SA
AFV
T
TGLG
K
RIA
Y
L
L
IG
K
I
G
N
T
TL
G
LGY
V
T
VF
L
DLVLAP
A
TPSNTAR
A
GGIV
L
PII
N
SVAVA
LG
S
E
P
EK
S
P
R
-
R
V
G
H
YLM
MS
IY
M
V
T
KT
TS
Y
MF
F
TAMA
G
N
I
L
A
L
KM
I
ND
I
L
H
L
--
QISWG
G
W
A
L
AA
GL
P
GII
M
LL
V
T
P
LV
I
Y
TM
YPPEIK
KV
D
N
-
K
T
I
A
KA
G
L
AE
L
GP
M
KI
REK
M
LLG
V
F
VLAL
L
G
WIF
S
KSL
-
GV
D
E
S
S
V
A
IV
V
M
A
T
MLL
--
L
G
IV
T
W
E
D
V
V
K
NK
G
G
WNTL
I
W
YG
G
I
I
G
L
S
S
L
L
S
KV
K
F
F
E
W
L
A
EVFKN
N
L
A
F
D
GH
GN
--
V
-
AFF
V
I
I
F
LSI
IV
RYFFAS
G
SAY
I
V
AMLPV
FA
M
L
A
NVS
-
---
G
A
PL
MLT
A
L
A
L
LF
S
NS
Y
GG
M
V
T
H
Y
GGAA
GP
V
I
F
G
V
GY
NDIK
SW
W
LV
GA
VLT
I
L
T
FLV
HI
T
L
G
VW
WW
N
ML
I
GWN
fig|585396.4.peg.816
Escherichia coli O111:H- str. 11128 (13-475/477)
LA
I
PC
II
G
F
M
P
A
PAGL
SEL
AW
V
L
F
GIY
L
A
A
IVGL
VIK
P
F
P
EP
VV
LL
IAV
A
-
AS
M
-
-
--
---
----
VV
V
G
N
L
SDG
A
FK
T
T
A
V
LSG
Y
SS
G
T
T
WLVF
S
AF
T
L
SA
AFV
T
TGLG
K
RIA
Y
L
L
IG
K
I
G
N
T
TL
G
LGY
V
T
VF
L
DLVLAP
A
TPSNTAR
A
GGIV
L
PII
N
SVAVA
LG
S
E
P
EK
S
P
R
-
R
V
G
H
YLM
MS
IY
M
V
T
KT
TS
Y
MF
F
TAMA
G
N
I
L
A
L
KM
I
ND
I
L
H
L
--
QISWG
G
W
V
L
AA
GL
P
GII
M
LL
V
T
P
LV
I
Y
TM
YPPEIK
KV
D
N
-
K
T
I
A
KA
G
L
AE
L
GP
M
KI
REK
M
LLG
V
F
VLAL
L
G
WIF
S
KSL
-
GV
D
E
S
T
V
A
IV
V
M
A
T
MLL
--
L
G
IV
T
W
E
D
V
V
K
NK
G
G
WNTL
I
W
YG
G
I
I
G
L
S
S
L
L
S
KV
K
F
F
E
W
L
A
EVFKN
N
L
A
F
D
GH
GN
--
V
-
AFF
V
I
I
F
LSI
IV
RYFFAS
G
SAY
I
V
AMLPV
FA
M
L
A
NVS
-
---
G
A
PL
MLT
A
L
A
L
LF
S
NS
Y
GG
M
V
T
H
Y
GGAA
GP
V
I
F
G
V
GY
NDIK
SW
W
LV
GA
VLT
I
L
T
FLV
HI
T
L
G
VW
WW
N
ML
I
GWN
fig|1040638.4.peg.4982
Escherichia coli O104:H4 str. LB226692 (13-475/477)
LA
I
PC
II
G
F
M
P
A
PAGL
SEL
AW
V
L
F
GIY
L
A
A
IVGL
VIK
P
F
P
EP
VV
LL
IAV
A
-
AS
M
-
-
--
---
----
VV
V
G
N
L
SDG
A
FK
T
T
A
V
LSG
Y
SS
G
T
T
WLVF
S
AF
T
L
SA
AFV
T
TGLG
K
RIA
Y
L
L
IG
K
I
G
N
T
TL
G
LGY
V
T
VF
L
DLVLAP
A
TPSNTAR
A
GGIV
L
PII
N
SVAVA
LG
S
E
P
EK
S
P
R
-
R
V
G
H
YLM
MS
IY
M
V
T
KT
TS
Y
MF
F
TAMA
G
N
I
L
A
L
KM
I
ND
I
L
H
L
--
QISWG
G
W
A
L
AA
GL
P
GII
M
LL
V
T
P
LV
I
Y
TM
YPPEIK
KV
D
N
-
K
T
I
A
KA
G
L
AE
L
GP
M
KI
REK
M
LLG
V
F
VLAL
L
G
WIF
S
KSL
-
GV
D
E
S
T
V
A
IV
V
M
A
T
MLL
--
L
G
IV
T
W
E
D
V
V
K
NK
G
G
WNTL
I
W
YG
G
I
I
G
L
S
S
L
L
S
KV
K
F
F
E
W
L
A
EVFKN
N
L
A
F
D
GH
GN
--
V
-
AFF
V
I
I
F
LSI
IV
RYFFAS
G
SAY
I
V
AMLPV
FA
M
L
A
NVS
-
---
G
A
PL
MLT
A
L
A
L
LF
S
NS
Y
GG
M
V
T
H
Y
GGAA
GP
V
I
F
G
V
GY
NDIK
SW
W
LV
GA
VLT
I
L
T
FLV
HI
T
L
G
VW
WW
N
ML
I
GWN
fig|216592.1.peg.3226
Escherichia coli 042 (13-475/477)
LA
I
PC
II
G
F
M
P
A
PAGL
SEL
AW
V
L
F
GIY
L
A
A
IVGL
VIK
P
F
P
EP
VV
LL
IAV
A
-
AS
M
-
-
--
---
----
VV
V
G
N
L
SDG
A
FK
T
T
A
V
LSG
Y
SS
G
T
T
WLVF
S
AF
T
L
SA
AFV
T
TGLG
K
RIA
Y
L
L
IG
K
I
G
N
T
TL
G
LGY
V
T
VF
L
DLVLAP
A
TPSNTAR
A
GGIV
L
PII
N
SVAVA
LG
S
E
P
EK
S
P
R
-
R
V
G
H
YLM
MS
IY
M
V
T
KT
TS
Y
MF
F
TAMA
G
N
I
L
A
L
KM
I
ND
I
L
H
L
--
QISWG
G
W
A
L
AA
GL
P
GII
M
LL
V
T
P
LV
I
Y
TM
YPPEIK
KV
D
N
-
K
T
I
A
KA
G
L
AE
L
GP
M
KI
REK
M
LLG
V
F
VLAL
L
G
WIF
S
KSL
-
GV
D
E
S
T
V
A
IV
V
M
A
T
MLL
--
L
G
IV
T
W
E
D
V
V
K
NK
G
G
WNTL
I
W
YG
G
I
I
G
L
S
S
L
L
S
KV
K
F
F
E
W
L
A
EVFKN
N
L
A
F
D
GH
GN
--
V
-
AFF
V
I
I
F
LSI
IV
RYFFAS
G
SAY
I
V
AMLPV
FA
M
L
A
NVS
-
---
G
A
PL
MLT
A
L
A
L
LF
S
NS
Y
GG
M
V
T
H
Y
GGAA
GP
V
I
F
G
V
GY
NDIK
SW
W
LV
GA
VLT
I
L
T
FLV
HI
T
L
G
VW
WW
N
ML
I
GWN
fig|216592.3.peg.823
Escherichia coli 042 (13-475/477)
LA
I
PC
II
G
F
M
P
A
PAGL
SEL
AW
V
L
F
GIY
L
A
A
IVGL
VIK
P
F
P
EP
VV
LL
IAV
A
-
AS
M
-
-
--
---
----
VV
V
G
N
L
SDG
A
FK
T
T
A
V
LSG
Y
SS
G
T
T
WLVF
S
AF
T
L
SA
AFV
T
TGLG
K
RIA
Y
L
L
IG
K
I
G
N
T
TL
G
LGY
V
T
VF
L
DLVLAP
A
TPSNTAR
A
GGIV
L
PII
N
SVAVA
LG
S
E
P
EK
S
P
R
-
R
V
G
H
YLM
MS
IY
M
V
T
KT
TS
Y
MF
F
TAMA
G
N
I
L
A
L
KM
I
ND
I
L
H
L
--
QISWG
G
W
A
L
AA
GL
P
GII
M
LL
V
T
P
LV
I
Y
TM
YPPEIK
KV
D
N
-
K
T
I
A
KA
G
L
AE
L
GP
M
KI
REK
M
LLG
V
F
VLAL
L
G
WIF
S
KSL
-
GV
D
E
S
T
V
A
IV
V
M
A
T
MLL
--
L
G
IV
T
W
E
D
V
V
K
NK
G
G
WNTL
I
W
YG
G
I
I
G
L
S
S
L
L
S
KV
K
F
F
E
W
L
A
EVFKN
N
L
A
F
D
GH
GN
--
V
-
AFF
V
I
I
F
LSI
IV
RYFFAS
G
SAY
I
V
AMLPV
FA
M
L
A
NVS
-
---
G
A
PL
MLT
A
L
A
L
LF
S
NS
Y
GG
M
V
T
H
Y
GGAA
GP
V
I
F
G
V
GY
NDIK
SW
W
LV
GA
VLT
I
L
T
FLV
HI
T
L
G
VW
WW
N
ML
I
GWN
fig|358709.5.peg.4508
Escherichia coli 101-1 (13-475/477)
LA
I
PC
II
G
F
M
P
A
PAGL
SEL
AW
V
L
F
GIY
L
A
A
IVGL
VIK
P
F
P
EP
VV
LL
IAV
A
-
AS
M
-
-
--
---
----
VV
V
G
N
L
SDG
A
FK
T
T
A
V
LSG
Y
SS
G
T
T
WLVF
S
AF
T
L
SA
AFV
T
TGLG
K
RIA
Y
L
L
IG
K
I
G
N
T
TL
G
LGY
V
T
VF
L
DLVLAP
A
TPSNTAR
A
GGIV
L
PII
N
SVAVA
LG
S
E
P
EK
S
P
R
-
R
V
G
H
YLM
MS
IY
M
V
T
KT
TS
Y
MF
F
TAMA
G
N
I
L
A
L
KM
I
ND
I
L
H
L
--
QISWG
G
W
A
L
AA
GL
P
GII
M
LL
V
T
P
LV
I
Y
TM
YPPEIK
KV
D
N
-
K
T
I
A
KA
G
L
AE
L
GP
M
KI
REK
M
LLG
V
F
VLAL
L
G
WIF
S
KSL
-
GV
D
E
S
T
V
A
IV
V
M
A
T
MLL
--
L
G
IV
T
W
E
D
V
V
K
NK
G
G
WNTL
I
W
YG
G
I
I
G
L
S
S
L
L
S
KV
K
F
F
E
W
L
A
EVFKN
N
L
A
F
D
GH
GN
--
V
-
AFF
V
I
I
F
LSI
IV
RYFFAS
G
SAY
I
V
AMLPV
FA
M
L
A
NVS
-
---
G
A
PL
MLT
A
L
A
L
LF
S
NS
Y
GG
M
V
T
H
Y
GGAA
GP
V
I
F
G
V
GY
NDIK
SW
W
LV
GA
VLT
I
L
T
FLV
HI
T
L
G
VW
WW
N
ML
I
GWN
fig|670888.3.peg.1328
Escherichia coli 1827-70 (13-475/477)
LA
I
PC
II
G
F
M
P
A
PAGL
SEL
AW
V
L
F
GIY
L
A
A
IVGL
VIK
P
F
P
EP
VV
LL
IAV
A
-
AS
M
-
-
--
---
----
VV
V
G
N
L
SDG
A
FK
T
T
A
V
LSG
Y
SS
G
T
T
WLVF
S
AF
T
L
SA
AFV
T
TGLG
K
RIA
Y
L
L
IG
K
I
G
N
T
TL
G
LGY
V
T
VF
L
DLVLAP
A
TPSNTAR
A
GGIV
L
PII
N
SVAVA
LG
S
E
P
EK
S
P
R
-
R
V
G
H
YLM
MS
IY
M
V
T
KT
TS
Y
MF
F
TAMA
G
N
I
L
A
L
KM
I
ND
I
L
H
L
--
QISWG
G
W
A
L
AA
GL
P
GII
M
LL
V
T
P
LV
I
Y
TM
YPPEIK
KV
D
N
-
K
T
I
A
KA
G
L
AE
L
GP
M
KI
REK
M
LLG
V
F
VLAL
L
G
WIF
S
KSL
-
GV
D
E
S
T
V
A
IV
V
M
A
T
MLL
--
L
G
IV
T
W
E
D
V
V
K
NK
G
G
WNTL
I
W
YG
G
I
I
G
L
S
S
L
L
S
KV
K
F
F
E
W
L
A
EVFKN
N
L
A
F
D
GH
GN
--
V
-
AFF
V
I
I
F
LSI
IV
RYFFAS
G
SAY
I
V
AMLPV
FA
M
L
A
NVS
-
---
G
A
PL
MLT
A
L
A
L
LF
S
NS
Y
GG
M
V
T
H
Y
GGAA
GP
V
I
F
G
V
GY
NDIK
SW
W
LV
GA
VLT
I
L
T
FLV
HI
T
L
G
VW
WW
N
ML
I
GWN
fig|344610.3.peg.4646
Escherichia coli 53638 (13-475/477)
LA
I
PC
II
G
F
M
P
A
PAGL
SEL
AW
V
L
F
GIY
L
A
A
IVGL
VIK
P
F
P
EP
VV
LL
IAV
A
-
AS
M
-
-
--
---
----
VV
V
G
N
L
SDG
A
FK
T
T
A
V
LSG
Y
SS
G
T
T
WLVF
S
AF
T
L
SA
AFV
T
TGLG
K
RIA
Y
L
L
IG
K
I
G
N
T
TL
G
LGY
V
T
VF
L
DLVLAP
A
TPSNTAR
A
GGIV
L
PII
N
SVAVA
LG
S
E
P
EK
S
P
R
-
R
V
G
H
YLM
MS
IY
M
V
T
KT
TS
Y
MF
F
TAMA
G
N
I
L
A
L
KM
I
ND
I
L
H
L
--
QISWG
G
W
A
L
AA
GL
P
GII
M
LL
V
T
P
LV
I
Y
TM
YPPEIK
KV
D
N
-
K
T
I
A
KA
G
L
AE
L
GP
M
KI
REK
M
LLG
V
F
VLAL
L
G
WIF
S
KSL
-
GV
D
E
S
T
V
A
IV
V
M
A
T
MLL
--
L
G
IV
T
W
E
D
V
V
K
NK
G
G
WNTL
I
W
YG
G
I
I
G
L
S
S
L
L
S
KV
K
F
F
E
W
L
A
EVFKN
N
L
A
F
D
GH
GN
--
V
-
AFF
V
I
I
F
LSI
IV
RYFFAS
G
SAY
I
V
AMLPV
FA
M
L
A
NVS
-
---
G
A
PL
MLT
A
L
A
L
LF
S
NS
Y
GG
M
V
T
H
Y
GGAA
GP
V
I
F
G
V
GY
NDIK
SW
W
LV
GA
VLT
I
L
T
FLV
HI
T
L
G
VW
WW
N
ML
I
GWN
fig|344610.7.peg.919
Escherichia coli 53638 (13-475/477)
LA
I
PC
II
G
F
M
P
A
PAGL
SEL
AW
V
L
F
GIY
L
A
A
IVGL
VIK
P
F
P
EP
VV
LL
IAV
A
-
AS
M
-
-
--
---
----
VV
V
G
N
L
SDG
A
FK
T
T
A
V
LSG
Y
SS
G
T
T
WLVF
S
AF
T
L
SA
AFV
T
TGLG
K
RIA
Y
L
L
IG
K
I
G
N
T
TL
G
LGY
V
T
VF
L
DLVLAP
A
TPSNTAR
A
GGIV
L
PII
N
SVAVA
LG
S
E
P
EK
S
P
R
-
R
V
G
H
YLM
MS
IY
M
V
T
KT
TS
Y
MF
F
TAMA
G
N
I
L
A
L
KM
I
ND
I
L
H
L
--
QISWG
G
W
A
L
AA
GL
P
GII
M
LL
V
T
P
LV
I
Y
TM
YPPEIK
KV
D
N
-
K
T
I
A
KA
G
L
AE
L
GP
M
KI
REK
M
LLG
V
F
VLAL
L
G
WIF
S
KSL
-
GV
D
E
S
T
V
A
IV
V
M
A
T
MLL
--
L
G
IV
T
W
E
D
V
V
K
NK
G
G
WNTL
I
W
YG
G
I
I
G
L
S
S
L
L
S
KV
K
F
F
E
W
L
A
EVFKN
N
L
A
F
D
GH
GN
--
V
-
AFF
V
I
I
F
LSI
IV
RYFFAS
G
SAY
I
V
AMLPV
FA
M
L
A
NVS
-
---
G
A
PL
MLT
A
L
A
L
LF
S
NS
Y
GG
M
V
T
H
Y
GGAA
GP
V
I
F
G
V
GY
NDIK
SW
W
LV
GA
VLT
I
L
T
FLV
HI
T
L
G
VW
WW
N
ML
I
GWN
fig|585055.6.peg.763
Escherichia coli 55989 (13-475/477)
LA
I
PC
II
G
F
M
P
A
PAGL
SEL
AW
V
L
F
GIY
L
A
A
IVGL
VIK
P
F
P
EP
VV
LL
IAV
A
-
AS
M
-
-
--
---
----
VV
V
G
N
L
SDG
A
FK
T
T
A
V
LSG
Y
SS
G
T
T
WLVF
S
AF
T
L
SA
AFV
T
TGLG
K
RIA
Y
L
L
IG
K
I
G
N
T
TL
G
LGY
V
T
VF
L
DLVLAP
A
TPSNTAR
A
GGIV
L
PII
N
SVAVA
LG
S
E
P
EK
S
P
R
-
R
V
G
H
YLM
MS
IY
M
V
T
KT
TS
Y
MF
F
TAMA
G
N
I
L
A
L
KM
I
ND
I
L
H
L
--
QISWG
G
W
A
L
AA
GL
P
GII
M
LL
V
T
P
LV
I
Y
TM
YPPEIK
KV
D
N
-
K
T
I
A
KA
G
L
AE
L
GP
M
KI
REK
M
LLG
V
F
VLAL
L
G
WIF
S
KSL
-
GV
D
E
S
T
V
A
IV
V
M
A
T
MLL
--
L
G
IV
T
W
E
D
V
V
K
NK
G
G
WNTL
I
W
YG
G
I
I
G
L
S
S
L
L
S
KV
K
F
F
E
W
L
A
EVFKN
N
L
A
F
D
GH
GN
--
V
-
AFF
V
I
I
F
LSI
IV
RYFFAS
G
SAY
I
V
AMLPV
FA
M
L
A
NVS
-
---
G
A
PL
MLT
A
L
A
L
LF
S
NS
Y
GG
M
V
T
H
Y
GGAA
GP
V
I
F
G
V
GY
NDIK
SW
W
LV
GA
VLT
I
L
T
FLV
HI
T
L
G
VW
WW
N
ML
I
GWN
fig|585055.8.peg.765
Escherichia coli 55989 (13-475/477)
LA
I
PC
II
G
F
M
P
A
PAGL
SEL
AW
V
L
F
GIY
L
A
A
IVGL
VIK
P
F
P
EP
VV
LL
IAV
A
-
AS
M
-
-
--
---
----
VV
V
G
N
L
SDG
A
FK
T
T
A
V
LSG
Y
SS
G
T
T
WLVF
S
AF
T
L
SA
AFV
T
TGLG
K
RIA
Y
L
L
IG
K
I
G
N
T
TL
G
LGY
V
T
VF
L
DLVLAP
A
TPSNTAR
A
GGIV
L
PII
N
SVAVA
LG
S
E
P
EK
S
P
R
-
R
V
G
H
YLM
MS
IY
M
V
T
KT
TS
Y
MF
F
TAMA
G
N
I
L
A
L
KM
I
ND
I
L
H
L
--
QISWG
G
W
A
L
AA
GL
P
GII
M
LL
V
T
P
LV
I
Y
TM
YPPEIK
KV
D
N
-
K
T
I
A
KA
G
L
AE
L
GP
M
KI
REK
M
LLG
V
F
VLAL
L
G
WIF
S
KSL
-
GV
D
E
S
T
V
A
IV
V
M
A
T
MLL
--
L
G
IV
T
W
E
D
V
V
K
NK
G
G
WNTL
I
W
YG
G
I
I
G
L
S
S
L
L
S
KV
K
F
F
E
W
L
A
EVFKN
N
L
A
F
D
GH
GN
--
V
-
AFF
V
I
I
F
LSI
IV
RYFFAS
G
SAY
I
V
AMLPV
FA
M
L
A
NVS
-
---
G
A
PL
MLT
A
L
A
L
LF
S
NS
Y
GG
M
V
T
H
Y
GGAA
GP
V
I
F
G
V
GY
NDIK
SW
W
LV
GA
VLT
I
L
T
FLV
HI
T
L
G
VW
WW
N
ML
I
GWN
fig|481805.3.peg.3101
Escherichia coli ATCC 8739 (13-475/477)
LA
I
PC
II
G
F
M
P
A
PAGL
SEL
AW
V
L
F
GIY
L
A
A
IVGL
VIK
P
F
P
EP
VV
LL
IAV
A
-
AS
M
-
-
--
---
----
VV
V
G
N
L
SDG
A
FK
T
T
A
V
LSG
Y
SS
G
T
T
WLVF
S
AF
T
L
SA
AFV
T
TGLG
K
RIA
Y
L
L
IG
K
I
G
N
T
TL
G
LGY
V
T
VF
L
DLVLAP
A
TPSNTAR
A
GGIV
L
PII
N
SVAVA
LG
S
E
P
EK
S
P
R
-
R
V
G
H
YLM
MS
IY
M
V
T
KT
TS
Y
MF
F
TAMA
G
N
I
L
A
L
KM
I
ND
I
L
H
L
--
QISWG
G
W
A
L
AA
GL
P
GII
M
LL
V
T
P
LV
I
Y
TM
YPPEIK
KV
D
N
-
K
T
I
A
KA
G
L
AE
L
GP
M
KI
REK
M
LLG
V
F
VLAL
L
G
WIF
S
KSL
-
GV
D
E
S
T
V
A
IV
V
M
A
T
MLL
--
L
G
IV
T
W
E
D
V
V
K
NK
G
G
WNTL
I
W
YG
G
I
I
G
L
S
S
L
L
S
KV
K
F
F
E
W
L
A
EVFKN
N
L
A
F
D
GH
GN
--
V
-
AFF
V
I
I
F
LSI
IV
RYFFAS
G
SAY
I
V
AMLPV
FA
M
L
A
NVS
-
---
G
A
PL
MLT
A
L
A
L
LF
S
NS
Y
GG
M
V
T
H
Y
GGAA
GP
V
I
F
G
V
GY
NDIK
SW
W
LV
GA
VLT
I
L
T
FLV
HI
T
L
G
VW
WW
N
ML
I
GWN
fig|481805.6.peg.3086
Escherichia coli ATCC 8739 (13-475/477)
LA
I
PC
II
G
F
M
P
A
PAGL
SEL
AW
V
L
F
GIY
L
A
A
IVGL
VIK
P
F
P
EP
VV
LL
IAV
A
-
AS
M
-
-
--
---
----
VV
V
G
N
L
SDG
A
FK
T
T
A
V
LSG
Y
SS
G
T
T
WLVF
S
AF
T
L
SA
AFV
T
TGLG
K
RIA
Y
L
L
IG
K
I
G
N
T
TL
G
LGY
V
T
VF
L
DLVLAP
A
TPSNTAR
A
GGIV
L
PII
N
SVAVA
LG
S
E
P
EK
S
P
R
-
R
V
G
H
YLM
MS
IY
M
V
T
KT
TS
Y
MF
F
TAMA
G
N
I
L
A
L
KM
I
ND
I
L
H
L
--
QISWG
G
W
A
L
AA
GL
P
GII
M
LL
V
T
P
LV
I
Y
TM
YPPEIK
KV
D
N
-
K
T
I
A
KA
G
L
AE
L
GP
M
KI
REK
M
LLG
V
F
VLAL
L
G
WIF
S
KSL
-
GV
D
E
S
T
V
A
IV
V
M
A
T
MLL
--
L
G
IV
T
W
E
D
V
V
K
NK
G
G
WNTL
I
W
YG
G
I
I
G
L
S
S
L
L
S
KV
K
F
F
E
W
L
A
EVFKN
N
L
A
F
D
GH
GN
--
V
-
AFF
V
I
I
F
LSI
IV
RYFFAS
G
SAY
I
V
AMLPV
FA
M
L
A
NVS
-
---
G
A
PL
MLT
A
L
A
L
LF
S
NS
Y
GG
M
V
T
H
Y
GGAA
GP
V
I
F
G
V
GY
NDIK
SW
W
LV
GA
VLT
I
L
T
FLV
HI
T
L
G
VW
WW
N
ML
I
GWN
fig|344601.3.peg.4035
Escherichia coli B171 (13-475/477)
LA
I
PC
II
G
F
M
P
A
PAGL
SEL
AW
V
L
F
GIY
L
A
A
IVGL
VIK
P
F
P
EP
VV
LL
IAV
A
-
AS
M
-
-
--
---
----
VV
V
G
N
L
SDG
A
FK
T
T
A
V
LSG
Y
SS
G
T
T
WLVF
S
AF
T
L
SA
AFV
T
TGLG
K
RIA
Y
L
L
IG
K
I
G
N
T
TL
G
LGY
V
T
VF
L
DLVLAP
A
TPSNTAR
A
GGIV
L
PII
N
SVAVA
LG
S
E
P
EK
S
P
R
-
R
V
G
H
YLM
MS
IY
M
V
T
KT
TS
Y
MF
F
TAMA
G
N
I
L
A
L
KM
I
ND
I
L
H
L
--
QISWG
G
W
A
L
AA
GL
P
GII
M
LL
V
T
P
LV
I
Y
TM
YPPEIK
KV
D
N
-
K
T
I
A
KA
G
L
AE
L
GP
M
KI
REK
M
LLG
V
F
VLAL
L
G
WIF
S
KSL
-
GV
D
E
S
T
V
A
IV
V
M
A
T
MLL
--
L
G
IV
T
W
E
D
V
V
K
NK
G
G
WNTL
I
W
YG
G
I
I
G
L
S
S
L
L
S
KV
K
F
F
E
W
L
A
EVFKN
N
L
A
F
D
GH
GN
--
V
-
AFF
V
I
I
F
LSI
IV
RYFFAS
G
SAY
I
V
AMLPV
FA
M
L
A
NVS
-
---
G
A
PL
MLT
A
L
A
L
LF
S
NS
Y
GG
M
V
T
H
Y
GGAA
GP
V
I
F
G
V
GY
NDIK
SW
W
LV
GA
VLT
I
L
T
FLV
HI
T
L
G
VW
WW
N
ML
I
GWN
fig|344601.5.peg.4248
Escherichia coli B171 (13-475/477)
LA
I
PC
II
G
F
M
P
A
PAGL
SEL
AW
V
L
F
GIY
L
A
A
IVGL
VIK
P
F
P
EP
VV
LL
IAV
A
-
AS
M
-
-
--
---
----
VV
V
G
N
L
SDG
A
FK
T
T
A
V
LSG
Y
SS
G
T
T
WLVF
S
AF
T
L
SA
AFV
T
TGLG
K
RIA
Y
L
L
IG
K
I
G
N
T
TL
G
LGY
V
T
VF
L
DLVLAP
A
TPSNTAR
A
GGIV
L
PII
N
SVAVA
LG
S
E
P
EK
S
P
R
-
R
V
G
H
YLM
MS
IY
M
V
T
KT
TS
Y
MF
F
TAMA
G
N
I
L
A
L
KM
I
ND
I
L
H
L
--
QISWG
G
W
A
L
AA
GL
P
GII
M
LL
V
T
P
LV
I
Y
TM
YPPEIK
KV
D
N
-
K
T
I
A
KA
G
L
AE
L
GP
M
KI
REK
M
LLG
V
F
VLAL
L
G
WIF
S
KSL
-
GV
D
E
S
T
V
A
IV
V
M
A
T
MLL
--
L
G
IV
T
W
E
D
V
V
K
NK
G
G
WNTL
I
W
YG
G
I
I
G
L
S
S
L
L
S
KV
K
F
F
E
W
L
A
EVFKN
N
L
A
F
D
GH
GN
--
V
-
AFF
V
I
I
F
LSI
IV
RYFFAS
G
SAY
I
V
AMLPV
FA
M
L
A
NVS
-
---
G
A
PL
MLT
A
L
A
L
LF
S
NS
Y
GG
M
V
T
H
Y
GGAA
GP
V
I
F
G
V
GY
NDIK
SW
W
LV
GA
VLT
I
L
T
FLV
HI
T
L
G
VW
WW
N
ML
I
GWN
fig|550676.3.peg.230
Escherichia coli B185 (13-475/477)
LA
I
PC
II
G
F
M
P
A
PAGL
SEL
AW
V
L
F
GIY
L
A
A
IVGL
VIK
P
F
P
EP
VV
LL
IAV
A
-
AS
M
-
-
--
---
----
VV
V
G
N
L
SDG
A
FK
T
T
A
V
LSG
Y
SS
G
T
T
WLVF
S
AF
T
L
SA
AFV
T
TGLG
K
RIA
Y
L
L
IG
K
I
G
N
T
TL
G
LGY
V
T
VF
L
DLVLAP
A
TPSNTAR
A
GGIV
L
PII
N
SVAVA
LG
S
E
P
EK
S
P
R
-
R
V
G
H
YLM
MS
IY
M
V
T
KT
TS
Y
MF
F
TAMA
G
N
I
L
A
L
KM
I
ND
I
L
H
L
--
QISWG
G
W
A
L
AA
GL
P
GII
M
LL
V
T
P
LV
I
Y
TM
YPPEIK
KV
D
N
-
K
T
I
A
KA
G
L
AE
L
GP
M
KI
REK
M
LLG
V
F
VLAL
L
G
WIF
S
KSL
-
GV
D
E
S
T
V
A
IV
V
M
A
T
MLL
--
L
G
IV
T
W
E
D
V
V
K
NK
G
G
WNTL
I
W
YG
G
I
I
G
L
S
S
L
L
S
KV
K
F
F
E
W
L
A
EVFKN
N
L
A
F
D
GH
GN
--
V
-
AFF
V
I
I
F
LSI
IV
RYFFAS
G
SAY
I
V
AMLPV
FA
M
L
A
NVS
-
---
G
A
PL
MLT
A
L
A
L
LF
S
NS
Y
GG
M
V
T
H
Y
GGAA
GP
V
I
F
G
V
GY
NDIK
SW
W
LV
GA
VLT
I
L
T
FLV
HI
T
L
G
VW
WW
N
ML
I
GWN
fig|550677.3.peg.2037
Escherichia coli B354 (13-475/477)
LA
I
PC
II
G
F
M
P
A
PAGL
SEL
AW
V
L
F
GIY
L
A
A
IVGL
VIK
P
F
P
EP
VV
LL
IAV
A
-
AS
M
-
-
--
---
----
VV
V
G
N
L
SDG
A
FK
T
T
A
V
LSG
Y
SS
G
T
T
WLVF
S
AF
T
L
SA
AFV
T
TGLG
K
RIA
Y
L
L
IG
K
I
G
N
T
TL
G
LGY
V
T
VF
L
DLVLAP
A
TPSNTAR
A
GGIV
L
PII
N
SVAVA
LG
S
E
P
EK
S
P
R
-
R
V
G
H
YLM
MS
IY
M
V
T
KT
TS
Y
MF
F
TAMA
G
N
I
L
A
L
KM
I
ND
I
L
H
L
--
QISWG
G
W
A
L
AA
GL
P
GII
M
LL
V
T
P
LV
I
Y
TM
YPPEIK
KV
D
N
-
K
T
I
A
KA
G
L
AE
L
GP
M
KI
REK
M
LLG
V
F
VLAL
L
G
WIF
S
KSL
-
GV
D
E
S
T
V
A
IV
V
M
A
T
MLL
--
L
G
IV
T
W
E
D
V
V
K
NK
G
G
WNTL
I
W
YG
G
I
I
G
L
S
S
L
L
S
KV
K
F
F
E
W
L
A
EVFKN
N
L
A
F
D
GH
GN
--
V
-
AFF
V
I
I
F
LSI
IV
RYFFAS
G
SAY
I
V
AMLPV
FA
M
L
A
NVS
-
---
G
A
PL
MLT
A
L
A
L
LF
S
NS
Y
GG
M
V
T
H
Y
GGAA
GP
V
I
F
G
V
GY
NDIK
SW
W
LV
GA
VLT
I
L
T
FLV
HI
T
L
G
VW
WW
N
ML
I
GWN
fig|340184.3.peg.3524
Escherichia coli B7A (13-475/477)
LA
I
PC
II
G
F
M
P
A
PAGL
SEL
AW
V
L
F
GIY
L
A
A
IVGL
VIK
P
F
P
EP
VV
LL
IAV
A
-
AS
M
-
-
--
---
----
VV
V
G
N
L
SDG
A
FK
T
T
A
V
LSG
Y
SS
G
T
T
WLVF
S
AF
T
L
SA
AFV
T
TGLG
K
RIA
Y
L
L
IG
K
I
G
N
T
TL
G
LGY
V
T
VF
L
DLVLAP
A
TPSNTAR
A
GGIV
L
PII
N
SVAVA
LG
S
E
P
EK
S
P
R
-
R
V
G
H
YLM
MS
IY
M
V
T
KT
TS
Y
MF
F
TAMA
G
N
I
L
A
L
KM
I
ND
I
L
H
L
--
QISWG
G
W
A
L
AA
GL
P
GII
M
LL
V
T
P
LV
I
Y
TM
YPPEIK
KV
D
N
-
K
T
I
A
KA
G
L
AE
L
GP
M
KI
REK
M
LLG
V
F
VLAL
L
G
WIF
S
KSL
-
GV
D
E
S
T
V
A
IV
V
M
A
T
MLL
--
L
G
IV
T
W
E
D
V
V
K
NK
G
G
WNTL
I
W
YG
G
I
I
G
L
S
S
L
L
S
KV
K
F
F
E
W
L
A
EVFKN
N
L
A
F
D
GH
GN
--
V
-
AFF
V
I
I
F
LSI
IV
RYFFAS
G
SAY
I
V
AMLPV
FA
M
L
A
NVS
-
---
G
A
PL
MLT
A
L
A
L
LF
S
NS
Y
GG
M
V
T
H
Y
GGAA
GP
V
I
F
G
V
GY
NDIK
SW
W
LV
GA
VLT
I
L
T
FLV
HI
T
L
G
VW
WW
N
ML
I
GWN
fig|340184.6.peg.3687
Escherichia coli B7A (13-475/477)
LA
I
PC
II
G
F
M
P
A
PAGL
SEL
AW
V
L
F
GIY
L
A
A
IVGL
VIK
P
F
P
EP
VV
LL
IAV
A
-
AS
M
-
-
--
---
----
VV
V
G
N
L
SDG
A
FK
T
T
A
V
LSG
Y
SS
G
T
T
WLVF
S
AF
T
L
SA
AFV
T
TGLG
K
RIA
Y
L
L
IG
K
I
G
N
T
TL
G
LGY
V
T
VF
L
DLVLAP
A
TPSNTAR
A
GGIV
L
PII
N
SVAVA
LG
S
E
P
EK
S
P
R
-
R
V
G
H
YLM
MS
IY
M
V
T
KT
TS
Y
MF
F
TAMA
G
N
I
L
A
L
KM
I
ND
I
L
H
L
--
QISWG
G
W
A
L
AA
GL
P
GII
M
LL
V
T
P
LV
I
Y
TM
YPPEIK
KV
D
N
-
K
T
I
A
KA
G
L
AE
L
GP
M
KI
REK
M
LLG
V
F
VLAL
L
G
WIF
S
KSL
-
GV
D
E
S
T
V
A
IV
V
M
A
T
MLL
--
L
G
IV
T
W
E
D
V
V
K
NK
G
G
WNTL
I
W
YG
G
I
I
G
L
S
S
L
L
S
KV
K
F
F
E
W
L
A
EVFKN
N
L
A
F
D
GH
GN
--
V
-
AFF
V
I
I
F
LSI
IV
RYFFAS
G
SAY
I
V
AMLPV
FA
M
L
A
NVS
-
---
G
A
PL
MLT
A
L
A
L
LF
S
NS
Y
GG
M
V
T
H
Y
GGAA
GP
V
I
F
G
V
GY
NDIK
SW
W
LV
GA
VLT
I
L
T
FLV
HI
T
L
G
VW
WW
N
ML
I
GWN
fig|595496.3.peg.691
Escherichia coli BW2952 (13-475/477)
LA
I
PC
II
G
F
M
P
A
PAGL
SEL
AW
V
L
F
GIY
L
A
A
IVGL
VIK
P
F
P
EP
VV
LL
IAV
A
-
AS
M
-
-
--
---
----
VV
V
G
N
L
SDG
A
FK
T
T
A
V
LSG
Y
SS
G
T
T
WLVF
S
AF
T
L
SA
AFV
T
TGLG
K
RIA
Y
L
L
IG
K
I
G
N
T
TL
G
LGY
V
T
VF
L
DLVLAP
A
TPSNTAR
A
GGIV
L
PII
N
SVAVA
LG
S
E
P
EK
S
P
R
-
R
V
G
H
YLM
MS
IY
M
V
T
KT
TS
Y
MF
F
TAMA
G
N
I
L
A
L
KM
I
ND
I
L
H
L
--
QISWG
G
W
A
L
AA
GL
P
GII
M
LL
V
T
P
LV
I
Y
TM
YPPEIK
KV
D
N
-
K
T
I
A
KA
G
L
AE
L
GP
M
KI
REK
M
LLG
V
F
VLAL
L
G
WIF
S
KSL
-
GV
D
E
S
T
V
A
IV
V
M
A
T
MLL
--
L
G
IV
T
W
E
D
V
V
K
NK
G
G
WNTL
I
W
YG
G
I
I
G
L
S
S
L
L
S
KV
K
F
F
E
W
L
A
EVFKN
N
L
A
F
D
GH
GN
--
V
-
AFF
V
I
I
F
LSI
IV
RYFFAS
G
SAY
I
V
AMLPV
FA
M
L
A
NVS
-
---
G
A
PL
MLT
A
L
A
L
LF
S
NS
Y
GG
M
V
T
H
Y
GGAA
GP
V
I
F
G
V
GY
NDIK
SW
W
LV
GA
VLT
I
L
T
FLV
HI
T
L
G
VW
WW
N
ML
I
GWN
fig|536056.3.peg.3031
Escherichia coli DH1 (13-475/477)
LA
I
PC
II
G
F
M
P
A
PAGL
SEL
AW
V
L
F
GIY
L
A
A
IVGL
VIK
P
F
P
EP
VV
LL
IAV
A
-
AS
M
-
-
--
---
----
VV
V
G
N
L
SDG
A
FK
T
T
A
V
LSG
Y
SS
G
T
T
WLVF
S
AF
T
L
SA
AFV
T
TGLG
K
RIA
Y
L
L
IG
K
I
G
N
T
TL
G
LGY
V
T
VF
L
DLVLAP
A
TPSNTAR
A
GGIV
L
PII
N
SVAVA
LG
S
E
P
EK
S
P
R
-
R
V
G
H
YLM
MS
IY
M
V
T
KT
TS
Y
MF
F
TAMA
G
N
I
L
A
L
KM
I
ND
I
L
H
L
--
QISWG
G
W
A
L
AA
GL
P
GII
M
LL
V
T
P
LV
I
Y
TM
YPPEIK
KV
D
N
-
K
T
I
A
KA
G
L
AE
L
GP
M
KI
REK
M
LLG
V
F
VLAL
L
G
WIF
S
KSL
-
GV
D
E
S
T
V
A
IV
V
M
A
T
MLL
--
L
G
IV
T
W
E
D
V
V
K
NK
G
G
WNTL
I
W
YG
G
I
I
G
L
S
S
L
L
S
KV
K
F
F
E
W
L
A
EVFKN
N
L
A
F
D
GH
GN
--
V
-
AFF
V
I
I
F
LSI
IV
RYFFAS
G
SAY
I
V
AMLPV
FA
M
L
A
NVS
-
---
G
A
PL
MLT
A
L
A
L
LF
S
NS
Y
GG
M
V
T
H
Y
GGAA
GP
V
I
F
G
V
GY
NDIK
SW
W
LV
GA
VLT
I
L
T
FLV
HI
T
L
G
VW
WW
N
ML
I
GWN
fig|340186.3.peg.2728
Escherichia coli E110019 (13-475/477)
LA
I
PC
II
G
F
M
P
A
PAGL
SEL
AW
V
L
F
GIY
L
A
A
IVGL
VIK
P
F
P
EP
VV
LL
IAV
A
-
AS
M
-
-
--
---
----
VV
V
G
N
L
SDG
A
FK
T
T
A
V
LSG
Y
SS
G
T
T
WLVF
S
AF
T
L
SA
AFV
T
TGLG
K
RIA
Y
L
L
IG
K
I
G
N
T
TL
G
LGY
V
T
VF
L
DLVLAP
A
TPSNTAR
A
GGIV
L
PII
N
SVAVA
LG
S
E
P
EK
S
P
R
-
R
V
G
H
YLM
MS
IY
M
V
T
KT
TS
Y
MF
F
TAMA
G
N
I
L
A
L
KM
I
ND
I
L
H
L
--
QISWG
G
W
A
L
AA
GL
P
GII
M
LL
V
T
P
LV
I
Y
TM
YPPEIK
KV
D
N
-
K
T
I
A
KA
G
L
AE
L
GP
M
KI
REK
M
LLG
V
F
VLAL
L
G
WIF
S
KSL
-
GV
D
E
S
T
V
A
IV
V
M
A
T
MLL
--
L
G
IV
T
W
E
D
V
V
K
NK
G
G
WNTL
I
W
YG
G
I
I
G
L
S
S
L
L
S
KV
K
F
F
E
W
L
A
EVFKN
N
L
A
F
D
GH
GN
--
V
-
AFF
V
I
I
F
LSI
IV
RYFFAS
G
SAY
I
V
AMLPV
FA
M
L
A
NVS
-
---
G
A
PL
MLT
A
L
A
L
LF
S
NS
Y
GG
M
V
T
H
Y
GGAA
GP
V
I
F
G
V
GY
NDIK
SW
W
LV
GA
VLT
I
L
T
FLV
HI
T
L
G
VW
WW
N
ML
I
GWN
fig|340186.5.peg.2827
Escherichia coli E110019 (13-475/477)
LA
I
PC
II
G
F
M
P
A
PAGL
SEL
AW
V
L
F
GIY
L
A
A
IVGL
VIK
P
F
P
EP
VV
LL
IAV
A
-
AS
M
-
-
--
---
----
VV
V
G
N
L
SDG
A
FK
T
T
A
V
LSG
Y
SS
G
T
T
WLVF
S
AF
T
L
SA
AFV
T
TGLG
K
RIA
Y
L
L
IG
K
I
G
N
T
TL
G
LGY
V
T
VF
L
DLVLAP
A
TPSNTAR
A
GGIV
L
PII
N
SVAVA
LG
S
E
P
EK
S
P
R
-
R
V
G
H
YLM
MS
IY
M
V
T
KT
TS
Y
MF
F
TAMA
G
N
I
L
A
L
KM
I
ND
I
L
H
L
--
QISWG
G
W
A
L
AA
GL
P
GII
M
LL
V
T
P
LV
I
Y
TM
YPPEIK
KV
D
N
-
K
T
I
A
KA
G
L
AE
L
GP
M
KI
REK
M
LLG
V
F
VLAL
L
G
WIF
S
KSL
-
GV
D
E
S
T
V
A
IV
V
M
A
T
MLL
--
L
G
IV
T
W
E
D
V
V
K
NK
G
G
WNTL
I
W
YG
G
I
I
G
L
S
S
L
L
S
KV
K
F
F
E
W
L
A
EVFKN
N
L
A
F
D
GH
GN
--
V
-
AFF
V
I
I
F
LSI
IV
RYFFAS
G
SAY
I
V
AMLPV
FA
M
L
A
NVS
-
---
G
A
PL
MLT
A
L
A
L
LF
S
NS
Y
GG
M
V
T
H
Y
GGAA
GP
V
I
F
G
V
GY
NDIK
SW
W
LV
GA
VLT
I
L
T
FLV
HI
T
L
G
VW
WW
N
ML
I
GWN
fig|656379.3.peg.1551
Escherichia coli FVEC1302 (13-475/477)
LA
I
PC
II
G
F
M
P
A
PAGL
SEL
AW
V
L
F
GIY
L
A
A
IVGL
VIK
P
F
P
EP
VV
LL
IAV
A
-
AS
M
-
-
--
---
----
VV
V
G
N
L
SDG
A
FK
T
T
A
V
LSG
Y
SS
G
T
T
WLVF
S
AF
T
L
SA
AFV
T
TGLG
K
RIA
Y
L
L
IG
K
I
G
N
T
TL
G
LGY
V
T
VF
L
DLVLAP
A
TPSNTAR
A
GGIV
L
PII
N
SVAVA
LG
S
E
P
EK
S
P
R
-
R
V
G
H
YLM
MS
IY
M
V
T
KT
TS
Y
MF
F
TAMA
G
N
I
L
A
L
KM
I
ND
I
L
H
L
--
QISWG
G
W
A
L
AA
GL
P
GII
M
LL
V
T
P
LV
I
Y
TM
YPPEIK
KV
D
N
-
K
T
I
A
KA
G
L
AE
L
GP
M
KI
REK
M
LLG
V
F
VLAL
L
G
WIF
S
KSL
-
GV
D
E
S
T
V
A
IV
V
M
A
T
MLL
--
L
G
IV
T
W
E
D
V
V
K
NK
G
G
WNTL
I
W
YG
G
I
I
G
L
S
S
L
L
S
KV
K
F
F
E
W
L
A
EVFKN
N
L
A
F
D
GH
GN
--
V
-
AFF
V
I
I
F
LSI
IV
RYFFAS
G
SAY
I
V
AMLPV
FA
M
L
A
NVS
-
---
G
A
PL
MLT
A
L
A
L
LF
S
NS
Y
GG
M
V
T
H
Y
GGAA
GP
V
I
F
G
V
GY
NDIK
SW
W
LV
GA
VLT
I
L
T
FLV
HI
T
L
G
VW
WW
N
ML
I
GWN
fig|656380.3.peg.1376
Escherichia coli FVEC1412 (13-475/477)
LA
I
PC
II
G
F
M
P
A
PAGL
SEL
AW
V
L
F
GIY
L
A
A
IVGL
VIK
P
F
P
EP
VV
LL
IAV
A
-
AS
M
-
-
--
---
----
VV
V
G
N
L
SDG
A
FK
T
T
A
V
LSG
Y
SS
G
T
T
WLVF
S
AF
T
L
SA
AFV
T
TGLG
K
RIA
Y
L
L
IG
K
I
G
N
T
TL
G
LGY
V
T
VF
L
DLVLAP
A
TPSNTAR
A
GGIV
L
PII
N
SVAVA
LG
S
E
P
EK
S
P
R
-
R
V
G
H
YLM
MS
IY
M
V
T
KT
TS
Y
MF
F
TAMA
G
N
I
L
A
L
KM
I
ND
I
L
H
L
--
QISWG
G
W
A
L
AA
GL
P
GII
M
LL
V
T
P
LV
I
Y
TM
YPPEIK
KV
D
N
-
K
T
I
A
KA
G
L
AE
L
GP
M
KI
REK
M
LLG
V
F
VLAL
L
G
WIF
S
KSL
-
GV
D
E
S
T
V
A
IV
V
M
A
T
MLL
--
L
G
IV
T
W
E
D
V
V
K
NK
G
G
WNTL
I
W
YG
G
I
I
G
L
S
S
L
L
S
KV
K
F
F
E
W
L
A
EVFKN
N
L
A
F
D
GH
GN
--
V
-
AFF
V
I
I
F
LSI
IV
RYFFAS
G
SAY
I
V
AMLPV
FA
M
L
A
NVS
-
---
G
A
PL
MLT
A
L
A
L
LF
S
NS
Y
GG
M
V
T
H
Y
GGAA
GP
V
I
F
G
V
GY
NDIK
SW
W
LV
GA
VLT
I
L
T
FLV
HI
T
L
G
VW
WW
N
ML
I
GWN
fig|656408.3.peg.713
Escherichia coli H591 (13-475/477)
LA
I
PC
II
G
F
M
P
A
PAGL
SEL
AW
V
L
F
GIY
L
A
A
IVGL
VIK
P
F
P
EP
VV
LL
IAV
A
-
AS
M
-
-
--
---
----
VV
V
G
N
L
SDG
A
FK
T
T
A
V
LSG
Y
SS
G
T
T
WLVF
S
AF
T
L
SA
AFV
T
TGLG
K
RIA
Y
L
L
IG
K
I
G
N
T
TL
G
LGY
V
T
VF
L
DLVLAP
A
TPSNTAR
A
GGIV
L
PII
N
SVAVA
LG
S
E
P
EK
S
P
R
-
R
V
G
H
YLM
MS
IY
M
V
T
KT
TS
Y
MF
F
TAMA
G
N
I
L
A
L
KM
I
ND
I
L
H
L
--
QISWG
G
W
A
L
AA
GL
P
GII
M
LL
V
T
P
LV
I
Y
TM
YPPEIK
KV
D
N
-
K
T
I
A
KA
G
L
AE
L
GP
M
KI
REK
M
LLG
V
F
VLAL
L
G
WIF
S
KSL
-
GV
D
E
S
T
V
A
IV
V
M
A
T
MLL
--
L
G
IV
T
W
E
D
V
V
K
NK
G
G
WNTL
I
W
YG
G
I
I
G
L
S
S
L
L
S
KV
K
F
F
E
W
L
A
EVFKN
N
L
A
F
D
GH
GN
--
V
-
AFF
V
I
I
F
LSI
IV
RYFFAS
G
SAY
I
V
AMLPV
FA
M
L
A
NVS
-
---
G
A
PL
MLT
A
L
A
L
LF
S
NS
Y
GG
M
V
T
H
Y
GGAA
GP
V
I
F
G
V
GY
NDIK
SW
W
LV
GA
VLT
I
L
T
FLV
HI
T
L
G
VW
WW
N
ML
I
GWN
fig|656414.3.peg.952
Escherichia coli H736 (13-475/477)
LA
I
PC
II
G
F
M
P
A
PAGL
SEL
AW
V
L
F
GIY
L
A
A
IVGL
VIK
P
F
P
EP
VV
LL
IAV
A
-
AS
M
-
-
--
---
----
VV
V
G
N
L
SDG
A
FK
T
T
A
V
LSG
Y
SS
G
T
T
WLVF
S
AF
T
L
SA
AFV
T
TGLG
K
RIA
Y
L
L
IG
K
I
G
N
T
TL
G
LGY
V
T
VF
L
DLVLAP
A
TPSNTAR
A
GGIV
L
PII
N
SVAVA
LG
S
E
P
EK
S
P
R
-
R
V
G
H
YLM
MS
IY
M
V
T
KT
TS
Y
MF
F
TAMA
G
N
I
L
A
L
KM
I
ND
I
L
H
L
--
QISWG
G
W
A
L
AA
GL
P
GII
M
LL
V
T
P
LV
I
Y
TM
YPPEIK
KV
D
N
-
K
T
I
A
KA
G
L
AE
L
GP
M
KI
REK
M
LLG
V
F
VLAL
L
G
WIF
S
KSL
-
GV
D
E
S
T
V
A
IV
V
M
A
T
MLL
--
L
G
IV
T
W
E
D
V
V
K
NK
G
G
WNTL
I
W
YG
G
I
I
G
L
S
S
L
L
S
KV
K
F
F
E
W
L
A
EVFKN
N
L
A
F
D
GH
GN
--
V
-
AFF
V
I
I
F
LSI
IV
RYFFAS
G
SAY
I
V
AMLPV
FA
M
L
A
NVS
-
---
G
A
PL
MLT
A
L
A
L
LF
S
NS
Y
GG
M
V
T
H
Y
GGAA
GP
V
I
F
G
V
GY
NDIK
SW
W
LV
GA
VLT
I
L
T
FLV
HI
T
L
G
VW
WW
N
ML
I
GWN
fig|331112.3.peg.760
Escherichia coli HS (13-475/477)
LA
I
PC
II
G
F
M
P
A
PAGL
SEL
AW
V
L
F
GIY
L
A
A
IVGL
VIK
P
F
P
EP
VV
LL
IAV
A
-
AS
M
-
-
--
---
----
VV
V
G
N
L
SDG
A
FK
T
T
A
V
LSG
Y
SS
G
T
T
WLVF
S
AF
T
L
SA
AFV
T
TGLG
K
RIA
Y
L
L
IG
K
I
G
N
T
TL
G
LGY
V
T
VF
L
DLVLAP
A
TPSNTAR
A
GGIV
L
PII
N
SVAVA
LG
S
E
P
EK
S
P
R
-
R
V
G
H
YLM
MS
IY
M
V
T
KT
TS
Y
MF
F
TAMA
G
N
I
L
A
L
KM
I
ND
I
L
H
L
--
QISWG
G
W
A
L
AA
GL
P
GII
M
LL
V
T
P
LV
I
Y
TM
YPPEIK
KV
D
N
-
K
T
I
A
KA
G
L
AE
L
GP
M
KI
REK
M
LLG
V
F
VLAL
L
G
WIF
S
KSL
-
GV
D
E
S
T
V
A
IV
V
M
A
T
MLL
--
L
G
IV
T
W
E
D
V
V
K
NK
G
G
WNTL
I
W
YG
G
I
I
G
L
S
S
L
L
S
KV
K
F
F
E
W
L
A
EVFKN
N
L
A
F
D
GH
GN
--
V
-
AFF
V
I
I
F
LSI
IV
RYFFAS
G
SAY
I
V
AMLPV
FA
M
L
A
NVS
-
---
G
A
PL
MLT
A
L
A
L
LF
S
NS
Y
GG
M
V
T
H
Y
GGAA
GP
V
I
F
G
V
GY
NDIK
SW
W
LV
GA
VLT
I
L
T
FLV
HI
T
L
G
VW
WW
N
ML
I
GWN
fig|331112.6.peg.794
Escherichia coli HS (13-475/477)
LA
I
PC
II
G
F
M
P
A
PAGL
SEL
AW
V
L
F
GIY
L
A
A
IVGL
VIK
P
F
P
EP
VV
LL
IAV
A
-
AS
M
-
-
--
---
----
VV
V
G
N
L
SDG
A
FK
T
T
A
V
LSG
Y
SS
G
T
T
WLVF
S
AF
T
L
SA
AFV
T
TGLG
K
RIA
Y
L
L
IG
K
I
G
N
T
TL
G
LGY
V
T
VF
L
DLVLAP
A
TPSNTAR
A
GGIV
L
PII
N
SVAVA
LG
S
E
P
EK
S
P
R
-
R
V
G
H
YLM
MS
IY
M
V
T
KT
TS
Y
MF
F
TAMA
G
N
I
L
A
L
KM
I
ND
I
L
H
L
--
QISWG
G
W
A
L
AA
GL
P
GII
M
LL
V
T
P
LV
I
Y
TM
YPPEIK
KV
D
N
-
K
T
I
A
KA
G
L
AE
L
GP
M
KI
REK
M
LLG
V
F
VLAL
L
G
WIF
S
KSL
-
GV
D
E
S
T
V
A
IV
V
M
A
T
MLL
--
L
G
IV
T
W
E
D
V
V
K
NK
G
G
WNTL
I
W
YG
G
I
I
G
L
S
S
L
L
S
KV
K
F
F
E
W
L
A
EVFKN
N
L
A
F
D
GH
GN
--
V
-
AFF
V
I
I
F
LSI
IV
RYFFAS
G
SAY
I
V
AMLPV
FA
M
L
A
NVS
-
---
G
A
PL
MLT
A
L
A
L
LF
S
NS
Y
GG
M
V
T
H
Y
GGAA
GP
V
I
F
G
V
GY
NDIK
SW
W
LV
GA
VLT
I
L
T
FLV
HI
T
L
G
VW
WW
N
ML
I
GWN
fig|585034.4.peg.734
Escherichia coli IAI1 (13-475/477)
LA
I
PC
II
G
F
M
P
A
PAGL
SEL
AW
V
L
F
GIY
L
A
A
IVGL
VIK
P
F
P
EP
VV
LL
IAV
A
-
AS
M
-
-
--
---
----
VV
V
G
N
L
SDG
A
FK
T
T
A
V
LSG
Y
SS
G
T
T
WLVF
S
AF
T
L
SA
AFV
T
TGLG
K
RIA
Y
L
L
IG
K
I
G
N
T
TL
G
LGY
V
T
VF
L
DLVLAP
A
TPSNTAR
A
GGIV
L
PII
N
SVAVA
LG
S
E
P
EK
S
P
R
-
R
V
G
H
YLM
MS
IY
M
V
T
KT
TS
Y
MF
F
TAMA
G
N
I
L
A
L
KM
I
ND
I
L
H
L
--
QISWG
G
W
A
L
AA
GL
P
GII
M
LL
V
T
P
LV
I
Y
TM
YPPEIK
KV
D
N
-
K
T
I
A
KA
G
L
AE
L
GP
M
KI
REK
M
LLG
V
F
VLAL
L
G
WIF
S
KSL
-
GV
D
E
S
T
V
A
IV
V
M
A
T
MLL
--
L
G
IV
T
W
E
D
V
V
K
NK
G
G
WNTL
I
W
YG
G
I
I
G
L
S
S
L
L
S
KV
K
F
F
E
W
L
A
EVFKN
N
L
A
F
D
GH
GN
--
V
-
AFF
V
I
I
F
LSI
IV
RYFFAS
G
SAY
I
V
AMLPV
FA
M
L
A
NVS
-
---
G
A
PL
MLT
A
L
A
L
LF
S
NS
Y
GG
M
V
T
H
Y
GGAA
GP
V
I
F
G
V
GY
NDIK
SW
W
LV
GA
VLT
I
L
T
FLV
HI
T
L
G
VW
WW
N
ML
I
GWN
fig|585034.5.peg.734
Escherichia coli IAI1 (13-475/477)
LA
I
PC
II
G
F
M
P
A
PAGL
SEL
AW
V
L
F
GIY
L
A
A
IVGL
VIK
P
F
P
EP
VV
LL
IAV
A
-
AS
M
-
-
--
---
----
VV
V
G
N
L
SDG
A
FK
T
T
A
V
LSG
Y
SS
G
T
T
WLVF
S
AF
T
L
SA
AFV
T
TGLG
K
RIA
Y
L
L
IG
K
I
G
N
T
TL
G
LGY
V
T
VF
L
DLVLAP
A
TPSNTAR
A
GGIV
L
PII
N
SVAVA
LG
S
E
P
EK
S
P
R
-
R
V
G
H
YLM
MS
IY
M
V
T
KT
TS
Y
MF
F
TAMA
G
N
I
L
A
L
KM
I
ND
I
L
H
L
--
QISWG
G
W
A
L
AA
GL
P
GII
M
LL
V
T
P
LV
I
Y
TM
YPPEIK
KV
D
N
-
K
T
I
A
KA
G
L
AE
L
GP
M
KI
REK
M
LLG
V
F
VLAL
L
G
WIF
S
KSL
-
GV
D
E
S
T
V
A
IV
V
M
A
T
MLL
--
L
G
IV
T
W
E
D
V
V
K
NK
G
G
WNTL
I
W
YG
G
I
I
G
L
S
S
L
L
S
KV
K
F
F
E
W
L
A
EVFKN
N
L
A
F
D
GH
GN
--
V
-
AFF
V
I
I
F
LSI
IV
RYFFAS
G
SAY
I
V
AMLPV
FA
M
L
A
NVS
-
---
G
A
PL
MLT
A
L
A
L
LF
S
NS
Y
GG
M
V
T
H
Y
GGAA
GP
V
I
F
G
V
GY
NDIK
SW
W
LV
GA
VLT
I
L
T
FLV
HI
T
L
G
VW
WW
N
ML
I
GWN
fig|83333.1.peg.756
Escherichia coli K12 (13-475/477)
LA
I
PC
II
G
F
M
P
A
PAGL
SEL
AW
V
L
F
GIY
L
A
A
IVGL
VIK
P
F
P
EP
VV
LL
IAV
A
-
AS
M
-
-
--
---
----
VV
V
G
N
L
SDG
A
FK
T
T
A
V
LSG
Y
SS
G
T
T
WLVF
S
AF
T
L
SA
AFV
T
TGLG
K
RIA
Y
L
L
IG
K
I
G
N
T
TL
G
LGY
V
T
VF
L
DLVLAP
A
TPSNTAR
A
GGIV
L
PII
N
SVAVA
LG
S
E
P
EK
S
P
R
-
R
V
G
H
YLM
MS
IY
M
V
T
KT
TS
Y
MF
F
TAMA
G
N
I
L
A
L
KM
I
ND
I
L
H
L
--
QISWG
G
W
A
L
AA
GL
P
GII
M
LL
V
T
P
LV
I
Y
TM
YPPEIK
KV
D
N
-
K
T
I
A
KA
G
L
AE
L
GP
M
KI
REK
M
LLG
V
F
VLAL
L
G
WIF
S
KSL
-
GV
D
E
S
T
V
A
IV
V
M
A
T
MLL
--
L
G
IV
T
W
E
D
V
V
K
NK
G
G
WNTL
I
W
YG
G
I
I
G
L
S
S
L
L
S
KV
K
F
F
E
W
L
A
EVFKN
N
L
A
F
D
GH
GN
--
V
-
AFF
V
I
I
F
LSI
IV
RYFFAS
G
SAY
I
V
AMLPV
FA
M
L
A
NVS
-
---
G
A
PL
MLT
A
L
A
L
LF
S
NS
Y
GG
M
V
T
H
Y
GGAA
GP
V
I
F
G
V
GY
NDIK
SW
W
LV
GA
VLT
I
L
T
FLV
HI
T
L
G
VW
WW
N
ML
I
GWN
fig|595495.4.peg.3255
Escherichia coli KO11 (13-475/477)
LA
I
PC
II
G
F
M
P
A
PAGL
SEL
AW
V
L
F
GIY
L
A
A
IVGL
VIK
P
F
P
EP
VV
LL
IAV
A
-
AS
M
-
-
--
---
----
VV
V
G
N
L
SDG
A
FK
T
T
A
V
LSG
Y
SS
G
T
T
WLVF
S
AF
T
L
SA
AFV
T
TGLG
K
RIA
Y
L
L
IG
K
I
G
N
T
TL
G
LGY
V
T
VF
L
DLVLAP
A
TPSNTAR
A
GGIV
L
PII
N
SVAVA
LG
S
E
P
EK
S
P
R
-
R
V
G
H
YLM
MS
IY
M
V
T
KT
TS
Y
MF
F
TAMA
G
N
I
L
A
L
KM
I
ND
I
L
H
L
--
QISWG
G
W
A
L
AA
GL
P
GII
M
LL
V
T
P
LV
I
Y
TM
YPPEIK
KV
D
N
-
K
T
I
A
KA
G
L
AE
L
GP
M
KI
REK
M
LLG
V
F
VLAL
L
G
WIF
S
KSL
-
GV
D
E
S
T
V
A
IV
V
M
A
T
MLL
--
L
G
IV
T
W
E
D
V
V
K
NK
G
G
WNTL
I
W
YG
G
I
I
G
L
S
S
L
L
S
KV
K
F
F
E
W
L
A
EVFKN
N
L
A
F
D
GH
GN
--
V
-
AFF
V
I
I
F
LSI
IV
RYFFAS
G
SAY
I
V
AMLPV
FA
M
L
A
NVS
-
---
G
A
PL
MLT
A
L
A
L
LF
S
NS
Y
GG
M
V
T
H
Y
GGAA
GP
V
I
F
G
V
GY
NDIK
SW
W
LV
GA
VLT
I
L
T
FLV
HI
T
L
G
VW
WW
N
ML
I
GWN
fig|656419.3.peg.1051
Escherichia coli M718 (13-475/477)
LA
I
PC
II
G
F
M
P
A
PAGL
SEL
AW
V
L
F
GIY
L
A
A
IVGL
VIK
P
F
P
EP
VV
LL
IAV
A
-
AS
M
-
-
--
---
----
VV
V
G
N
L
SDG
A
FK
T
T
A
V
LSG
Y
SS
G
T
T
WLVF
S
AF
T
L
SA
AFV
T
TGLG
K
RIA
Y
L
L
IG
K
I
G
N
T
TL
G
LGY
V
T
VF
L
DLVLAP
A
TPSNTAR
A
GGIV
L
PII
N
SVAVA
LG
S
E
P
EK
S
P
R
-
R
V
G
H
YLM
MS
IY
M
V
T
KT
TS
Y
MF
F
TAMA
G
N
I
L
A
L
KM
I
ND
I
L
H
L
--
QISWG
G
W
A
L
AA
GL
P
GII
M
LL
V
T
P
LV
I
Y
TM
YPPEIK
KV
D
N
-
K
T
I
A
KA
G
L
AE
L
GP
M
KI
REK
M
LLG
V
F
VLAL
L
G
WIF
S
KSL
-
GV
D
E
S
T
V
A
IV
V
M
A
T
MLL
--
L
G
IV
T
W
E
D
V
V
K
NK
G
G
WNTL
I
W
YG
G
I
I
G
L
S
S
L
L
S
KV
K
F
F
E
W
L
A
EVFKN
N
L
A
F
D
GH
GN
--
V
-
AFF
V
I
I
F
LSI
IV
RYFFAS
G
SAY
I
V
AMLPV
FA
M
L
A
NVS
-
---
G
A
PL
MLT
A
L
A
L
LF
S
NS
Y
GG
M
V
T
H
Y
GGAA
GP
V
I
F
G
V
GY
NDIK
SW
W
LV
GA
VLT
I
L
T
FLV
HI
T
L
G
VW
WW
N
ML
I
GWN
fig|679207.4.peg.1425
Escherichia coli MS 107-1 (13-475/477)
LA
I
PC
II
G
F
M
P
A
PAGL
SEL
AW
V
L
F
GIY
L
A
A
IVGL
VIK
P
F
P
EP
VV
LL
IAV
A
-
AS
M
-
-
--
---
----
VV
V
G
N
L
SDG
A
FK
T
T
A
V
LSG
Y
SS
G
T
T
WLVF
S
AF
T
L
SA
AFV
T
TGLG
K
RIA
Y
L
L
IG
K
I
G
N
T
TL
G
LGY
V
T
VF
L
DLVLAP
A
TPSNTAR
A
GGIV
L
PII
N
SVAVA
LG
S
E
P
EK
S
P
R
-
R
V
G
H
YLM
MS
IY
M
V
T
KT
TS
Y
MF
F
TAMA
G
N
I
L
A
L
KM
I
ND
I
L
H
L
--
QISWG
G
W
A
L
AA
GL
P
GII
M
LL
V
T
P
LV
I
Y
TM
YPPEIK
KV
D
N
-
K
T
I
A
KA
G
L
AE
L
GP
M
KI
REK
M
LLG
V
F
VLAL
L
G
WIF
S
KSL
-
GV
D
E
S
T
V
A
IV
V
M
A
T
MLL
--
L
G
IV
T
W
E
D
V
V
K
NK
G
G
WNTL
I
W
YG
G
I
I
G
L
S
S
L
L
S
KV
K
F
F
E
W
L
A
EVFKN
N
L
A
F
D
GH
GN
--
V
-
AFF
V
I
I
F
LSI
IV
RYFFAS
G
SAY
I
V
AMLPV
FA
M
L
A
NVS
-
---
G
A
PL
MLT
A
L
A
L
LF
S
NS
Y
GG
M
V
T
H
Y
GGAA
GP
V
I
F
G
V
GY
NDIK
SW
W
LV
GA
VLT
I
L
T
FLV
HI
T
L
G
VW
WW
N
ML
I
GWN
fig|749537.3.peg.3461
Escherichia coli MS 115-1 (13-475/477)
LA
I
PC
II
G
F
M
P
A
PAGL
SEL
AW
V
L
F
GIY
L
A
A
IVGL
VIK
P
F
P
EP
VV
LL
IAV
A
-
AS
M
-
-
--
---
----
VV
V
G
N
L
SDG
A
FK
T
T
A
V
LSG
Y
SS
G
T
T
WLVF
S
AF
T
L
SA
AFV
T
TGLG
K
RIA
Y
L
L
IG
K
I
G
N
T
TL
G
LGY
V
T
VF
L
DLVLAP
A
TPSNTAR
A
GGIV
L
PII
N
SVAVA
LG
S
E
P
EK
S
P
R
-
R
V
G
H
YLM
MS
IY
M
V
T
KT
TS
Y
MF
F
TAMA
G
N
I
L
A
L
KM
I
ND
I
L
H
L
--
QISWG
G
W
A
L
AA
GL
P
GII
M
LL
V
T
P
LV
I
Y
TM
YPPEIK
KV
D
N
-
K
T
I
A
KA
G
L
AE
L
GP
M
KI
REK
M
LLG
V
F
VLAL
L
G
WIF
S
KSL
-
GV
D
E
S
T
V
A
IV
V
M
A
T
MLL
--
L
G
IV
T
W
E
D
V
V
K
NK
G
G
WNTL
I
W
YG
G
I
I
G
L
S
S
L
L
S
KV
K
F
F
E
W
L
A
EVFKN
N
L
A
F
D
GH
GN
--
V
-
AFF
V
I
I
F
LSI
IV
RYFFAS
G
SAY
I
V
AMLPV
FA
M
L
A
NVS
-
---
G
A
PL
MLT
A
L
A
L
LF
S
NS
Y
GG
M
V
T
H
Y
GGAA
GP
V
I
F
G
V
GY
NDIK
SW
W
LV
GA
VLT
I
L
T
FLV
HI
T
L
G
VW
WW
N
ML
I
GWN
fig|749538.3.peg.763
Escherichia coli MS 116-1 (13-475/477)
LA
I
PC
II
G
F
M
P
A
PAGL
SEL
AW
V
L
F
GIY
L
A
A
IVGL
VIK
P
F
P
EP
VV
LL
IAV
A
-
AS
M
-
-
--
---
----
VV
V
G
N
L
SDG
A
FK
T
T
A
V
LSG
Y
SS
G
T
T
WLVF
S
AF
T
L
SA
AFV
T
TGLG
K
RIA
Y
L
L
IG
K
I
G
N
T
TL
G
LGY
V
T
VF
L
DLVLAP
A
TPSNTAR
A
GGIV
L
PII
N
SVAVA
LG
S
E
P
EK
S
P
R
-
R
V
G
H
YLM
MS
IY
M
V
T
KT
TS
Y
MF
F
TAMA
G
N
I
L
A
L
KM
I
ND
I
L
H
L
--
QISWG
G
W
A
L
AA
GL
P
GII
M
LL
V
T
P
LV
I
Y
TM
YPPEIK
KV
D
N
-
K
T
I
A
KA
G
L
AE
L
GP
M
KI
REK
M
LLG
V
F
VLAL
L
G
WIF
S
KSL
-
GV
D
E
S
T
V
A
IV
V
M
A
T
MLL
--
L
G
IV
T
W
E
D
V
V
K
NK
G
G
WNTL
I
W
YG
G
I
I
G
L
S
S
L
L
S
KV
K
F
F
E
W
L
A
EVFKN
N
L
A
F
D
GH
GN
--
V
-
AFF
V
I
I
F
LSI
IV
RYFFAS
G
SAY
I
V
AMLPV
FA
M
L
A
NVS
-
---
G
A
PL
MLT
A
L
A
L
LF
S
NS
Y
GG
M
V
T
H
Y
GGAA
GP
V
I
F
G
V
GY
NDIK
SW
W
LV
GA
VLT
I
L
T
FLV
HI
T
L
G
VW
WW
N
ML
I
GWN
fig|679206.4.peg.2719
Escherichia coli MS 119-7 (13-475/477)
LA
I
PC
II
G
F
M
P
A
PAGL
SEL
AW
V
L
F
GIY
L
A
A
IVGL
VIK
P
F
P
EP
VV
LL
IAV
A
-
AS
M
-
-
--
---
----
VV
V
G
N
L
SDG
A
FK
T
T
A
V
LSG
Y
SS
G
T
T
WLVF
S
AF
T
L
SA
AFV
T
TGLG
K
RIA
Y
L
L
IG
K
I
G
N
T
TL
G
LGY
V
T
VF
L
DLVLAP
A
TPSNTAR
A
GGIV
L
PII
N
SVAVA
LG
S
E
P
EK
S
P
R
-
R
V
G
H
YLM
MS
IY
M
V
T
KT
TS
Y
MF
F
TAMA
G
N
I
L
A
L
KM
I
ND
I
L
H
L
--
QISWG
G
W
A
L
AA
GL
P
GII
M
LL
V
T
P
LV
I
Y
TM
YPPEIK
KV
D
N
-
K
T
I
A
KA
G
L
AE
L
GP
M
KI
REK
M
LLG
V
F
VLAL
L
G
WIF
S
KSL
-
GV
D
E
S
T
V
A
IV
V
M
A
T
MLL
--
L
G
IV
T
W
E
D
V
V
K
NK
G
G
WNTL
I
W
YG
G
I
I
G
L
S
S
L
L
S
KV
K
F
F
E
W
L
A
EVFKN
N
L
A
F
D
GH
GN
--
V
-
AFF
V
I
I
F
LSI
IV
RYFFAS
G
SAY
I
V
AMLPV
FA
M
L
A
NVS
-
---
G
A
PL
MLT
A
L
A
L
LF
S
NS
Y
GG
M
V
T
H
Y
GGAA
GP
V
I
F
G
V
GY
NDIK
SW
W
LV
GA
VLT
I
L
T
FLV
HI
T
L
G
VW
WW
N
ML
I
GWN
fig|679205.4.peg.2532
Escherichia coli MS 124-1 (13-475/477)
LA
I
PC
II
G
F
M
P
A
PAGL
SEL
AW
V
L
F
GIY
L
A
A
IVGL
VIK
P
F
P
EP
VV
LL
IAV
A
-
AS
M
-
-
--
---
----
VV
V
G
N
L
SDG
A
FK
T
T
A
V
LSG
Y
SS
G
T
T
WLVF
S
AF
T
L
SA
AFV
T
TGLG
K
RIA
Y
L
L
IG
K
I
G
N
T
TL
G
LGY
V
T
VF
L
DLVLAP
A
TPSNTAR
A
GGIV
L
PII
N
SVAVA
LG
S
E
P
EK
S
P
R
-
R
V
G
H
YLM
MS
IY
M
V
T
KT
TS
Y
MF
F
TAMA
G
N
I
L
A
L
KM
I
ND
I
L
H
L
--
QISWG
G
W
A
L
AA
GL
P
GII
M
LL
V
T
P
LV
I
Y
TM
YPPEIK
KV
D
N
-
K
T
I
A
KA
G
L
AE
L
GP
M
KI
REK
M
LLG
V
F
VLAL
L
G
WIF
S
KSL
-
GV
D
E
S
T
V
A
IV
V
M
A
T
MLL
--
L
G
IV
T
W
E
D
V
V
K
NK
G
G
WNTL
I
W
YG
G
I
I
G
L
S
S
L
L
S
KV
K
F
F
E
W
L
A
EVFKN
N
L
A
F
D
GH
GN
--
V
-
AFF
V
I
I
F
LSI
IV
RYFFAS
G
SAY
I
V
AMLPV
FA
M
L
A
NVS
-
---
G
A
PL
MLT
A
L
A
L
LF
S
NS
Y
GG
M
V
T
H
Y
GGAA
GP
V
I
F
G
V
GY
NDIK
SW
W
LV
GA
VLT
I
L
T
FLV
HI
T
L
G
VW
WW
N
ML
I
GWN
fig|679204.3.peg.4152
Escherichia coli MS 145-7 (13-475/477)
LA
I
PC
II
G
F
M
P
A
PAGL
SEL
AW
V
L
F
GIY
L
A
A
IVGL
VIK
P
F
P
EP
VV
LL
IAV
A
-
AS
M
-
-
--
---
----
VV
V
G
N
L
SDG
A
FK
T
T
A
V
LSG
Y
SS
G
T
T
WLVF
S
AF
T
L
SA
AFV
T
TGLG
K
RIA
Y
L
L
IG
K
I
G
N
T
TL
G
LGY
V
T
VF
L
DLVLAP
A
TPSNTAR
A
GGIV
L
PII
N
SVAVA
LG
S
E
P
EK
S
P
R
-
R
V
G
H
YLM
MS
IY
M
V
T
KT
TS
Y
MF
F
TAMA
G
N
I
L
A
L
KM
I
ND
I
L
H
L
--
QISWG
G
W
A
L
AA
GL
P
GII
M
LL
V
T
P
LV
I
Y
TM
YPPEIK
KV
D
N
-
K
T
I
A
KA
G
L
AE
L
GP
M
KI
REK
M
LLG
V
F
VLAL
L
G
WIF
S
KSL
-
GV
D
E
S
T
V
A
IV
V
M
A
T
MLL
--
L
G
IV
T
W
E
D
V
V
K
NK
G
G
WNTL
I
W
YG
G
I
I
G
L
S
S
L
L
S
KV
K
F
F
E
W
L
A
EVFKN
N
L
A
F
D
GH
GN
--
V
-
AFF
V
I
I
F
LSI
IV
RYFFAS
G
SAY
I
V
AMLPV
FA
M
L
A
NVS
-
---
G
A
PL
MLT
A
L
A
L
LF
S
NS
Y
GG
M
V
T
H
Y
GGAA
GP
V
I
F
G
V
GY
NDIK
SW
W
LV
GA
VLT
I
L
T
FLV
HI
T
L
G
VW
WW
N
ML
I
GWN
fig|749540.3.peg.2681
Escherichia coli MS 146-1 (13-475/477)
LA
I
PC
II
G
F
M
P
A
PAGL
SEL
AW
V
L
F
GIY
L
A
A
IVGL
VIK
P
F
P
EP
VV
LL
IAV
A
-
AS
M
-
-
--
---
----
VV
V
G
N
L
SDG
A
FK
T
T
A
V
LSG
Y
SS
G
T
T
WLVF
S
AF
T
L
SA
AFV
T
TGLG
K
RIA
Y
L
L
IG
K
I
G
N
T
TL
G
LGY
V
T
VF
L
DLVLAP
A
TPSNTAR
A
GGIV
L
PII
N
SVAVA
LG
S
E
P
EK
S
P
R
-
R
V
G
H
YLM
MS
IY
M
V
T
KT
TS
Y
MF
F
TAMA
G
N
I
L
A
L
KM
I
ND
I
L
H
L
--
QISWG
G
W
A
L
AA
GL
P
GII
M
LL
V
T
P
LV
I
Y
TM
YPPEIK
KV
D
N
-
K
T
I
A
KA
G
L
AE
L
GP
M
KI
REK
M
LLG
V
F
VLAL
L
G
WIF
S
KSL
-
GV
D
E
S
T
V
A
IV
V
M
A
T
MLL
--
L
G
IV
T
W
E
D
V
V
K
NK
G
G
WNTL
I
W
YG
G
I
I
G
L
S
S
L
L
S
KV
K
F
F
E
W
L
A
EVFKN
N
L
A
F
D
GH
GN
--
V
-
AFF
V
I
I
F
LSI
IV
RYFFAS
G
SAY
I
V
AMLPV
FA
M
L
A
NVS
-
---
G
A
PL
MLT
A
L
A
L
LF
S
NS
Y
GG
M
V
T
H
Y
GGAA
GP
V
I
F
G
V
GY
NDIK
SW
W
LV
GA
VLT
I
L
T
FLV
HI
T
L
G
VW
WW
N
ML
I
GWN
fig|749544.3.peg.3319
Escherichia coli MS 175-1 (13-475/477)
LA
I
PC
II
G
F
M
P
A
PAGL
SEL
AW
V
L
F
GIY
L
A
A
IVGL
VIK
P
F
P
EP
VV
LL
IAV
A
-
AS
M
-
-
--
---
----
VV
V
G
N
L
SDG
A
FK
T
T
A
V
LSG
Y
SS
G
T
T
WLVF
S
AF
T
L
SA
AFV
T
TGLG
K
RIA
Y
L
L
IG
K
I
G
N
T
TL
G
LGY
V
T
VF
L
DLVLAP
A
TPSNTAR
A
GGIV
L
PII
N
SVAVA
LG
S
E
P
EK
S
P
R
-
R
V
G
H
YLM
MS
IY
M
V
T
KT
TS
Y
MF
F
TAMA
G
N
I
L
A
L
KM
I
ND
I
L
H
L
--
QISWG
G
W
A
L
AA
GL
P
GII
M
LL
V
T
P
LV
I
Y
TM
YPPEIK
KV
D
N
-
K
T
I
A
KA
G
L
AE
L
GP
M
KI
REK
M
LLG
V
F
VLAL
L
G
WIF
S
KSL
-
GV
D
E
S
T
V
A
IV
V
M
A
T
MLL
--
L
G
IV
T
W
E
D
V
V
K
NK
G
G
WNTL
I
W
YG
G
I
I
G
L
S
S
L
L
S
KV
K
F
F
E
W
L
A
EVFKN
N
L
A
F
D
GH
GN
--
V
-
AFF
V
I
I
F
LSI
IV
RYFFAS
G
SAY
I
V
AMLPV
FA
M
L
A
NVS
-
---
G
A
PL
MLT
A
L
A
L
LF
S
NS
Y
GG
M
V
T
H
Y
GGAA
GP
V
I
F
G
V
GY
NDIK
SW
W
LV
GA
VLT
I
L
T
FLV
HI
T
L
G
VW
WW
N
ML
I
GWN
fig|749545.3.peg.3982
Escherichia coli MS 182-1 (13-475/477)
LA
I
PC
II
G
F
M
P
A
PAGL
SEL
AW
V
L
F
GIY
L
A
A
IVGL
VIK
P
F
P
EP
VV
LL
IAV
A
-
AS
M
-
-
--
---
----
VV
V
G
N
L
SDG
A
FK
T
T
A
V
LSG
Y
SS
G
T
T
WLVF
S
AF
T
L
SA
AFV
T
TGLG
K
RIA
Y
L
L
IG
K
I
G
N
T
TL
G
LGY
V
T
VF
L
DLVLAP
A
TPSNTAR
A
GGIV
L
PII
N
SVAVA
LG
S
E
P
EK
S
P
R
-
R
V
G
H
YLM
MS
IY
M
V
T
KT
TS
Y
MF
F
TAMA
G
N
I
L
A
L
KM
I
ND
I
L
H
L
--
QISWG
G
W
A
L
AA
GL
P
GII
M
LL
V
T
P
LV
I
Y
TM
YPPEIK
KV
D
N
-
K
T
I
A
KA
G
L
AE
L
GP
M
KI
REK
M
LLG
V
F
VLAL
L
G
WIF
S
KSL
-
GV
D
E
S
T
V
A
IV
V
M
A
T
MLL
--
L
G
IV
T
W
E
D
V
V
K
NK
G
G
WNTL
I
W
YG
G
I
I
G
L
S
S
L
L
S
KV
K
F
F
E
W
L
A
EVFKN
N
L
A
F
D
GH
GN
--
V
-
AFF
V
I
I
F
LSI
IV
RYFFAS
G
SAY
I
V
AMLPV
FA
M
L
A
NVS
-
---
G
A
PL
MLT
A
L
A
L
LF
S
NS
Y
GG
M
V
T
H
Y
GGAA
GP
V
I
F
G
V
GY
NDIK
SW
W
LV
GA
VLT
I
L
T
FLV
HI
T
L
G
VW
WW
N
ML
I
GWN
fig|749549.3.peg.2284
Escherichia coli MS 198-1 (13-475/477)
LA
I
PC
II
G
F
M
P
A
PAGL
SEL
AW
V
L
F
GIY
L
A
A
IVGL
VIK
P
F
P
EP
VV
LL
IAV
A
-
AS
M
-
-
--
---
----
VV
V
G
N
L
SDG
A
FK
T
T
A
V
LSG
Y
SS
G
T
T
WLVF
S
AF
T
L
SA
AFV
T
TGLG
K
RIA
Y
L
L
IG
K
I
G
N
T
TL
G
LGY
V
T
VF
L
DLVLAP
A
TPSNTAR
A
GGIV
L
PII
N
SVAVA
LG
S
E
P
EK
S
P
R
-
R
V
G
H
YLM
MS
IY
M
V
T
KT
TS
Y
MF
F
TAMA
G
N
I
L
A
L
KM
I
ND
I
L
H
L
--
QISWG
G
W
A
L
AA
GL
P
GII
M
LL
V
T
P
LV
I
Y
TM
YPPEIK
KV
D
N
-
K
T
I
A
KA
G
L
AE
L
GP
M
KI
REK
M
LLG
V
F
VLAL
L
G
WIF
S
KSL
-
GV
D
E
S
T
V
A
IV
V
M
A
T
MLL
--
L
G
IV
T
W
E
D
V
V
K
NK
G
G
WNTL
I
W
YG
G
I
I
G
L
S
S
L
L
S
KV
K
F
F
E
W
L
A
EVFKN
N
L
A
F
D
GH
GN
--
V
-
AFF
V
I
I
F
LSI
IV
RYFFAS
G
SAY
I
V
AMLPV
FA
M
L
A
NVS
-
---
G
A
PL
MLT
A
L
A
L
LF
S
NS
Y
GG
M
V
T
H
Y
GGAA
GP
V
I
F
G
V
GY
NDIK
SW
W
LV
GA
VLT
I
L
T
FLV
HI
T
L
G
VW
WW
N
ML
I
GWN
fig|749532.3.peg.2642
Escherichia coli MS 78-1 (13-475/477)
LA
I
PC
II
G
F
M
P
A
PAGL
SEL
AW
V
L
F
GIY
L
A
A
IVGL
VIK
P
F
P
EP
VV
LL
IAV
A
-
AS
M
-
-
--
---
----
VV
V
G
N
L
SDG
A
FK
T
T
A
V
LSG
Y
SS
G
T
T
WLVF
S
AF
T
L
SA
AFV
T
TGLG
K
RIA
Y
L
L
IG
K
I
G
N
T
TL
G
LGY
V
T
VF
L
DLVLAP
A
TPSNTAR
A
GGIV
L
PII
N
SVAVA
LG
S
E
P
EK
S
P
R
-
R
V
G
H
YLM
MS
IY
M
V
T
KT
TS
Y
MF
F
TAMA
G
N
I
L
A
L
KM
I
ND
I
L
H
L
--
QISWG
G
W
A
L
AA
GL
P
GII
M
LL
V
T
P
LV
I
Y
TM
YPPEIK
KV
D
N
-
K
T
I
A
KA
G
L
AE
L
GP
M
KI
REK
M
LLG
V
F
VLAL
L
G
WIF
S
KSL
-
GV
D
E
S
T
V
A
IV
V
M
A
T
MLL
--
L
G
IV
T
W
E
D
V
V
K
NK
G
G
WNTL
I
W
YG
G
I
I
G
L
S
S
L
L
S
KV
K
F
F
E
W
L
A
EVFKN
N
L
A
F
D
GH
GN
--
V
-
AFF
V
I
I
F
LSI
IV
RYFFAS
G
SAY
I
V
AMLPV
FA
M
L
A
NVS
-
---
G
A
PL
MLT
A
L
A
L
LF
S
NS
Y
GG
M
V
T
H
Y
GGAA
GP
V
I
F
G
V
GY
NDIK
SW
W
LV
GA
VLT
I
L
T
FLV
HI
T
L
G
VW
WW
N
ML
I
GWN
fig|749533.3.peg.4718
Escherichia coli MS 84-1 (13-475/477)
LA
I
PC
II
G
F
M
P
A
PAGL
SEL
AW
V
L
F
GIY
L
A
A
IVGL
VIK
P
F
P
EP
VV
LL
IAV
A
-
AS
M
-
-
--
---
----
VV
V
G
N
L
SDG
A
FK
T
T
A
V
LSG
Y
SS
G
T
T
WLVF
S
AF
T
L
SA
AFV
T
TGLG
K
RIA
Y
L
L
IG
K
I
G
N
T
TL
G
LGY
V
T
VF
L
DLVLAP
A
TPSNTAR
A
GGIV
L
PII
N
SVAVA
LG
S
E
P
EK
S
P
R
-
R
V
G
H
YLM
MS
IY
M
V
T
KT
TS
Y
MF
F
TAMA
G
N
I
L
A
L
KM
I
ND
I
L
H
L
--
QISWG
G
W
A
L
AA
GL
P
GII
M
LL
V
T
P
LV
I
Y
TM
YPPEIK
KV
D
N
-
K
T
I
A
KA
G
L
AE
L
GP
M
KI
REK
M
LLG
V
F
VLAL
L
G
WIF
S
KSL
-
GV
D
E
S
T
V
A
IV
V
M
A
T
MLL
--
L
G
IV
T
W
E
D
V
V
K
NK
G
G
WNTL
I
W
YG
G
I
I
G
L
S
S
L
L
S
KV
K
F
F
E
W
L
A
EVFKN
N
L
A
F
D
GH
GN
--
V
-
AFF
V
I
I
F
LSI
IV
RYFFAS
G
SAY
I
V
AMLPV
FA
M
L
A
NVS
-
---
G
A
PL
MLT
A
L
A
L
LF
S
NS
Y
GG
M
V
T
H
Y
GGAA
GP
V
I
F
G
V
GY
NDIK
SW
W
LV
GA
VLT
I
L
T
FLV
HI
T
L
G
VW
WW
N
ML
I
GWN
fig|585395.4.peg.802
Escherichia coli O103:H2 str. 12009 (13-475/477)
LA
I
PC
II
G
F
M
P
A
PAGL
SEL
AW
V
L
F
GIY
L
A
A
IVGL
VIK
P
F
P
EP
VV
LL
IAV
A
-
AS
M
-
-
--
---
----
VV
V
G
N
L
SDG
A
FK
T
T
A
V
LSG
Y
SS
G
T
T
WLVF
S
AF
T
L
SA
AFV
T
TGLG
K
RIA
Y
L
L
IG
K
I
G
N
T
TL
G
LGY
V
T
VF
L
DLVLAP
A
TPSNTAR
A
GGIV
L
PII
N
SVAVA
LG
S
E
P
EK
S
P
R
-
R
V
G
H
YLM
MS
IY
M
V
T
KT
TS
Y
MF
F
TAMA
G
N
I
L
A
L
KM
I
ND
I
L
H
L
--
QISWG
G
W
A
L
AA
GL
P
GII
M
LL
V
T
P
LV
I
Y
TM
YPPEIK
KV
D
N
-
K
T
I
A
KA
G
L
AE
L
GP
M
KI
REK
M
LLG
V
F
VLAL
L
G
WIF
S
KSL
-
GV
D
E
S
T
V
A
IV
V
M
A
T
MLL
--
L
G
IV
T
W
E
D
V
V
K
NK
G
G
WNTL
I
W
YG
G
I
I
G
L
S
S
L
L
S
KV
K
F
F
E
W
L
A
EVFKN
N
L
A
F
D
GH
GN
--
V
-
AFF
V
I
I
F
LSI
IV
RYFFAS
G
SAY
I
V
AMLPV
FA
M
L
A
NVS
-
---
G
A
PL
MLT
A
L
A
L
LF
S
NS
Y
GG
M
V
T
H
Y
GGAA
GP
V
I
F
G
V
GY
NDIK
SW
W
LV
GA
VLT
I
L
T
FLV
HI
T
L
G
VW
WW
N
ML
I
GWN
fig|656437.3.peg.849
Escherichia coli TA143 (13-475/477)
LA
I
PC
II
G
F
M
P
A
PAGL
SEL
AW
V
L
F
GIY
L
A
A
IVGL
VIK
P
F
P
EP
VV
LL
IAV
A
-
AS
M
-
-
--
---
----
VV
V
G
N
L
SDG
A
FK
T
T
A
V
LSG
Y
SS
G
T
T
WLVF
S
AF
T
L
SA
AFV
T
TGLG
K
RIA
Y
L
L
IG
K
I
G
N
T
TL
G
LGY
V
T
VF
L
DLVLAP
A
TPSNTAR
A
GGIV
L
PII
N
SVAVA
LG
S
E
P
EK
S
P
R
-
R
V
G
H
YLM
MS
IY
M
V
T
KT
TS
Y
MF
F
TAMA
G
N
I
L
A
L
KM
I
ND
I
L
H
L
--
QISWG
G
W
A
L
AA
GL
P
GII
M
LL
V
T
P
LV
I
Y
TM
YPPEIK
KV
D
N
-
K
T
I
A
KA
G
L
AE
L
GP
M
KI
REK
M
LLG
V
F
VLAL
L
G
WIF
S
KSL
-
GV
D
E
S
T
V
A
IV
V
M
A
T
MLL
--
L
G
IV
T
W
E
D
V
V
K
NK
G
G
WNTL
I
W
YG
G
I
I
G
L
S
S
L
L
S
KV
K
F
F
E
W
L
A
EVFKN
N
L
A
F
D
GH
GN
--
V
-
AFF
V
I
I
F
LSI
IV
RYFFAS
G
SAY
I
V
AMLPV
FA
M
L
A
NVS
-
---
G
A
PL
MLT
A
L
A
L
LF
S
NS
Y
GG
M
V
T
H
Y
GGAA
GP
V
I
F
G
V
GY
NDIK
SW
W
LV
GA
VLT
I
L
T
FLV
HI
T
L
G
VW
WW
N
ML
I
GWN
fig|656443.3.peg.1036
Escherichia coli TA271 (13-475/477)
LA
I
PC
II
G
F
M
P
A
PAGL
SEL
AW
V
L
F
GIY
L
A
A
IVGL
VIK
P
F
P
EP
VV
LL
IAV
A
-
AS
M
-
-
--
---
----
VV
V
G
N
L
SDG
A
FK
T
T
A
V
LSG
Y
SS
G
T
T
WLVF
S
AF
T
L
SA
AFV
T
TGLG
K
RIA
Y
L
L
IG
K
I
G
N
T
TL
G
LGY
V
T
VF
L
DLVLAP
A
TPSNTAR
A
GGIV
L
PII
N
SVAVA
LG
S
E
P
EK
S
P
R
-
R
V
G
H
YLM
MS
IY
M
V
T
KT
TS
Y
MF
F
TAMA
G
N
I
L
A
L
KM
I
ND
I
L
H
L
--
QISWG
G
W
A
L
AA
GL
P
GII
M
LL
V
T
P
LV
I
Y
TM
YPPEIK
KV
D
N
-
K
T
I
A
KA
G
L
AE
L
GP
M
KI
REK
M
LLG
V
F
VLAL
L
G
WIF
S
KSL
-
GV
D
E
S
T
V
A
IV
V
M
A
T
MLL
--
L
G
IV
T
W
E
D
V
V
K
NK
G
G
WNTL
I
W
YG
G
I
I
G
L
S
S
L
L
S
KV
K
F
F
E
W
L
A
EVFKN
N
L
A
F
D
GH
GN
--
V
-
AFF
V
I
I
F
LSI
IV
RYFFAS
G
SAY
I
V
AMLPV
FA
M
L
A
NVS
-
---
G
A
PL
MLT
A
L
A
L
LF
S
NS
Y
GG
M
V
T
H
Y
GGAA
GP
V
I
F
G
V
GY
NDIK
SW
W
LV
GA
VLT
I
L
T
FLV
HI
T
L
G
VW
WW
N
ML
I
GWN
fig|656444.3.peg.1317
Escherichia coli TA280 (13-475/477)
LA
I
PC
II
G
F
M
P
A
PAGL
SEL
AW
V
L
F
GIY
L
A
A
IVGL
VIK
P
F
P
EP
VV
LL
IAV
A
-
AS
M
-
-
--
---
----
VV
V
G
N
L
SDG
A
FK
T
T
A
V
LSG
Y
SS
G
T
T
WLVF
S
AF
T
L
SA
AFV
T
TGLG
K
RIA
Y
L
L
IG
K
I
G
N
T
TL
G
LGY
V
T
VF
L
DLVLAP
A
TPSNTAR
A
GGIV
L
PII
N
SVAVA
LG
S
E
P
EK
S
P
R
-
R
V
G
H
YLM
MS
IY
M
V
T
KT
TS
Y
MF
F
TAMA
G
N
I
L
A
L
KM
I
ND
I
L
H
L
--
QISWG
G
W
A
L
AA
GL
P
GII
M
LL
V
T
P
LV
I
Y
TM
YPPEIK
KV
D
N
-
K
T
I
A
KA
G
L
AE
L
GP
M
KI
REK
M
LLG
V
F
VLAL
L
G
WIF
S
KSL
-
GV
D
E
S
T
V
A
IV
V
M
A
T
MLL
--
L
G
IV
T
W
E
D
V
V
K
NK
G
G
WNTL
I
W
YG
G
I
I
G
L
S
S
L
L
S
KV
K
F
F
E
W
L
A
EVFKN
N
L
A
F
D
GH
GN
--
V
-
AFF
V
I
I
F
LSI
IV
RYFFAS
G
SAY
I
V
AMLPV
FA
M
L
A
NVS
-
---
G
A
PL
MLT
A
L
A
L
LF
S
NS
Y
GG
M
V
T
H
Y
GGAA
GP
V
I
F
G
V
GY
NDIK
SW
W
LV
GA
VLT
I
L
T
FLV
HI
T
L
G
VW
WW
N
ML
I
GWN
fig|585056.7.peg.1055
Escherichia coli UMN026 (13-475/477)
LA
I
PC
II
G
F
M
P
A
PAGL
SEL
AW
V
L
F
GIY
L
A
A
IVGL
VIK
P
F
P
EP
VV
LL
IAV
A
-
AS
M
-
-
--
---
----
VV
V
G
N
L
SDG
A
FK
T
T
A
V
LSG
Y
SS
G
T
T
WLVF
S
AF
T
L
SA
AFV
T
TGLG
K
RIA
Y
L
L
IG
K
I
G
N
T
TL
G
LGY
V
T
VF
L
DLVLAP
A
TPSNTAR
A
GGIV
L
PII
N
SVAVA
LG
S
E
P
EK
S
P
R
-
R
V
G
H
YLM
MS
IY
M
V
T
KT
TS
Y
MF
F
TAMA
G
N
I
L
A
L
KM
I
ND
I
L
H
L
--
QISWG
G
W
A
L
AA
GL
P
GII
M
LL
V
T
P
LV
I
Y
TM
YPPEIK
KV
D
N
-
K
T
I
A
KA
G
L
AE
L
GP
M
KI
REK
M
LLG
V
F
VLAL
L
G
WIF
S
KSL
-
GV
D
E
S
T
V
A
IV
V
M
A
T
MLL
--
L
G
IV
T
W
E
D
V
V
K
NK
G
G
WNTL
I
W
YG
G
I
I
G
L
S
S
L
L
S
KV
K
F
F
E
W
L
A
EVFKN
N
L
A
F
D
GH
GN
--
V
-
AFF
V
I
I
F
LSI
IV
RYFFAS
G
SAY
I
V
AMLPV
FA
M
L
A
NVS
-
---
G
A
PL
MLT
A
L
A
L
LF
S
NS
Y
GG
M
V
T
H
Y
GGAA
GP
V
I
F
G
V
GY
NDIK
SW
W
LV
GA
VLT
I
L
T
FLV
HI
T
L
G
VW
WW
N
ML
I
GWN
fig|566546.3.peg.3797
Escherichia coli W (13-475/477)
LA
I
PC
II
G
F
M
P
A
PAGL
SEL
AW
V
L
F
GIY
L
A
A
IVGL
VIK
P
F
P
EP
VV
LL
IAV
A
-
AS
M
-
-
--
---
----
VV
V
G
N
L
SDG
A
FK
T
T
A
V
LSG
Y
SS
G
T
T
WLVF
S
AF
T
L
SA
AFV
T
TGLG
K
RIA
Y
L
L
IG
K
I
G
N
T
TL
G
LGY
V
T
VF
L
DLVLAP
A
TPSNTAR
A
GGIV
L
PII
N
SVAVA
LG
S
E
P
EK
S
P
R
-
R
V
G
H
YLM
MS
IY
M
V
T
KT
TS
Y
MF
F
TAMA
G
N
I
L
A
L
KM
I
ND
I
L
H
L
--
QISWG
G
W
A
L
AA
GL
P
GII
M
LL
V
T
P
LV
I
Y
TM
YPPEIK
KV
D
N
-
K
T
I
A
KA
G
L
AE
L
GP
M
KI
REK
M
LLG
V
F
VLAL
L
G
WIF
S
KSL
-
GV
D
E
S
T
V
A
IV
V
M
A
T
MLL
--
L
G
IV
T
W
E
D
V
V
K
NK
G
G
WNTL
I
W
YG
G
I
I
G
L
S
S
L
L
S
KV
K
F
F
E
W
L
A
EVFKN
N
L
A
F
D
GH
GN
--
V
-
AFF
V
I
I
F
LSI
IV
RYFFAS
G
SAY
I
V
AMLPV
FA
M
L
A
NVS
-
---
G
A
PL
MLT
A
L
A
L
LF
S
NS
Y
GG
M
V
T
H
Y
GGAA
GP
V
I
F
G
V
GY
NDIK
SW
W
LV
GA
VLT
I
L
T
FLV
HI
T
L
G
VW
WW
N
ML
I
GWN
fig|566546.4.peg.819
Escherichia coli W (13-475/477)
LA
I
PC
II
G
F
M
P
A
PAGL
SEL
AW
V
L
F
GIY
L
A
A
IVGL
VIK
P
F
P
EP
VV
LL
IAV
A
-
AS
M
-
-
--
---
----
VV
V
G
N
L
SDG
A
FK
T
T
A
V
LSG
Y
SS
G
T
T
WLVF
S
AF
T
L
SA
AFV
T
TGLG
K
RIA
Y
L
L
IG
K
I
G
N
T
TL
G
LGY
V
T
VF
L
DLVLAP
A
TPSNTAR
A
GGIV
L
PII
N
SVAVA
LG
S
E
P
EK
S
P
R
-
R
V
G
H
YLM
MS
IY
M
V
T
KT
TS
Y
MF
F
TAMA
G
N
I
L
A
L
KM
I
ND
I
L
H
L
--
QISWG
G
W
A
L
AA
GL
P
GII
M
LL
V
T
P
LV
I
Y
TM
YPPEIK
KV
D
N
-
K
T
I
A
KA
G
L
AE
L
GP
M
KI
REK
M
LLG
V
F
VLAL
L
G
WIF
S
KSL
-
GV
D
E
S
T
V
A
IV
V
M
A
T
MLL
--
L
G
IV
T
W
E
D
V
V
K
NK
G
G
WNTL
I
W
YG
G
I
I
G
L
S
S
L
L
S
KV
K
F
F
E
W
L
A
EVFKN
N
L
A
F
D
GH
GN
--
V
-
AFF
V
I
I
F
LSI
IV
RYFFAS
G
SAY
I
V
AMLPV
FA
M
L
A
NVS
-
---
G
A
PL
MLT
A
L
A
L
LF
S
NS
Y
GG
M
V
T
H
Y
GGAA
GP
V
I
F
G
V
GY
NDIK
SW
W
LV
GA
VLT
I
L
T
FLV
HI
T
L
G
VW
WW
N
ML
I
GWN
fig|316407.3.peg.737
Escherichia coli W3110 (13-475/477)
LA
I
PC
II
G
F
M
P
A
PAGL
SEL
AW
V
L
F
GIY
L
A
A
IVGL
VIK
P
F
P
EP
VV
LL
IAV
A
-
AS
M
-
-
--
---
----
VV
V
G
N
L
SDG
A
FK
T
T
A
V
LSG
Y
SS
G
T
T
WLVF
S
AF
T
L
SA
AFV
T
TGLG
K
RIA
Y
L
L
IG
K
I
G
N
T
TL
G
LGY
V
T
VF
L
DLVLAP
A
TPSNTAR
A
GGIV
L
PII
N
SVAVA
LG
S
E
P
EK
S
P
R
-
R
V
G
H
YLM
MS
IY
M
V
T
KT
TS
Y
MF
F
TAMA
G
N
I
L
A
L
KM
I
ND
I
L
H
L
--
QISWG
G
W
A
L
AA
GL
P
GII
M
LL
V
T
P
LV
I
Y
TM
YPPEIK
KV
D
N
-
K
T
I
A
KA
G
L
AE
L
GP
M
KI
REK
M
LLG
V
F
VLAL
L
G
WIF
S
KSL
-
GV
D
E
S
T
V
A
IV
V
M
A
T
MLL
--
L
G
IV
T
W
E
D
V
V
K
NK
G
G
WNTL
I
W
YG
G
I
I
G
L
S
S
L
L
S
KV
K
F
F
E
W
L
A
EVFKN
N
L
A
F
D
GH
GN
--
V
-
AFF
V
I
I
F
LSI
IV
RYFFAS
G
SAY
I
V
AMLPV
FA
M
L
A
NVS
-
---
G
A
PL
MLT
A
L
A
L
LF
S
NS
Y
GG
M
V
T
H
Y
GGAA
GP
V
I
F
G
V
GY
NDIK
SW
W
LV
GA
VLT
I
L
T
FLV
HI
T
L
G
VW
WW
N
ML
I
GWN
fig|316385.7.peg.844
Escherichia coli str. K-12 substr. DH10B (13-475/477)
LA
I
PC
II
G
F
M
P
A
PAGL
SEL
AW
V
L
F
GIY
L
A
A
IVGL
VIK
P
F
P
EP
VV
LL
IAV
A
-
AS
M
-
-
--
---
----
VV
V
G
N
L
SDG
A
FK
T
T
A
V
LSG
Y
SS
G
T
T
WLVF
S
AF
T
L
SA
AFV
T
TGLG
K
RIA
Y
L
L
IG
K
I
G
N
T
TL
G
LGY
V
T
VF
L
DLVLAP
A
TPSNTAR
A
GGIV
L
PII
N
SVAVA
LG
S
E
P
EK
S
P
R
-
R
V
G
H
YLM
MS
IY
M
V
T
KT
TS
Y
MF
F
TAMA
G
N
I
L
A
L
KM
I
ND
I
L
H
L
--
QISWG
G
W
A
L
AA
GL
P
GII
M
LL
V
T
P
LV
I
Y
TM
YPPEIK
KV
D
N
-
K
T
I
A
KA
G
L
AE
L
GP
M
KI
REK
M
LLG
V
F
VLAL
L
G
WIF
S
KSL
-
GV
D
E
S
T
V
A
IV
V
M
A
T
MLL
--
L
G
IV
T
W
E
D
V
V
K
NK
G
G
WNTL
I
W
YG
G
I
I
G
L
S
S
L
L
S
KV
K
F
F
E
W
L
A
EVFKN
N
L
A
F
D
GH
GN
--
V
-
AFF
V
I
I
F
LSI
IV
RYFFAS
G
SAY
I
V
AMLPV
FA
M
L
A
NVS
-
---
G
A
PL
MLT
A
L
A
L
LF
S
NS
Y
GG
M
V
T
H
Y
GGAA
GP
V
I
F
G
V
GY
NDIK
SW
W
LV
GA
VLT
I
L
T
FLV
HI
T
L
G
VW
WW
N
ML
I
GWN
fig|511145.12.peg.796
Escherichia coli str. K-12 substr. MG1655 (13-475/477)
LA
I
PC
II
G
F
M
P
A
PAGL
SEL
AW
V
L
F
GIY
L
A
A
IVGL
VIK
P
F
P
EP
VV
LL
IAV
A
-
AS
M
-
-
--
---
----
VV
V
G
N
L
SDG
A
FK
T
T
A
V
LSG
Y
SS
G
T
T
WLVF
S
AF
T
L
SA
AFV
T
TGLG
K
RIA
Y
L
L
IG
K
I
G
N
T
TL
G
LGY
V
T
VF
L
DLVLAP
A
TPSNTAR
A
GGIV
L
PII
N
SVAVA
LG
S
E
P
EK
S
P
R
-
R
V
G
H
YLM
MS
IY
M
V
T
KT
TS
Y
MF
F
TAMA
G
N
I
L
A
L
KM
I
ND
I
L
H
L
--
QISWG
G
W
A
L
AA
GL
P
GII
M
LL
V
T
P
LV
I
Y
TM
YPPEIK
KV
D
N
-
K
T
I
A
KA
G
L
AE
L
GP
M
KI
REK
M
LLG
V
F
VLAL
L
G
WIF
S
KSL
-
GV
D
E
S
T
V
A
IV
V
M
A
T
MLL
--
L
G
IV
T
W
E
D
V
V
K
NK
G
G
WNTL
I
W
YG
G
I
I
G
L
S
S
L
L
S
KV
K
F
F
E
W
L
A
EVFKN
N
L
A
F
D
GH
GN
--
V
-
AFF
V
I
I
F
LSI
IV
RYFFAS
G
SAY
I
V
AMLPV
FA
M
L
A
NVS
-
---
G
A
PL
MLT
A
L
A
L
LF
S
NS
Y
GG
M
V
T
H
Y
GGAA
GP
V
I
F
G
V
GY
NDIK
SW
W
LV
GA
VLT
I
L
T
FLV
HI
T
L
G
VW
WW
N
ML
I
GWN
fig|511145.6.peg.787
Escherichia coli str. K-12 substr. MG1655 (13-475/477)
LA
I
PC
II
G
F
M
P
A
PAGL
SEL
AW
V
L
F
GIY
L
A
A
IVGL
VIK
P
F
P
EP
VV
LL
IAV
A
-
AS
M
-
-
--
---
----
VV
V
G
N
L
SDG
A
FK
T
T
A
V
LSG
Y
SS
G
T
T
WLVF
S
AF
T
L
SA
AFV
T
TGLG
K
RIA
Y
L
L
IG
K
I
G
N
T
TL
G
LGY
V
T
VF
L
DLVLAP
A
TPSNTAR
A
GGIV
L
PII
N
SVAVA
LG
S
E
P
EK
S
P
R
-
R
V
G
H
YLM
MS
IY
M
V
T
KT
TS
Y
MF
F
TAMA
G
N
I
L
A
L
KM
I
ND
I
L
H
L
--
QISWG
G
W
A
L
AA
GL
P
GII
M
LL
V
T
P
LV
I
Y
TM
YPPEIK
KV
D
N
-
K
T
I
A
KA
G
L
AE
L
GP
M
KI
REK
M
LLG
V
F
VLAL
L
G
WIF
S
KSL
-
GV
D
E
S
T
V
A
IV
V
M
A
T
MLL
--
L
G
IV
T
W
E
D
V
V
K
NK
G
G
WNTL
I
W
YG
G
I
I
G
L
S
S
L
L
S
KV
K
F
F
E
W
L
A
EVFKN
N
L
A
F
D
GH
GN
--
V
-
AFF
V
I
I
F
LSI
IV
RYFFAS
G
SAY
I
V
AMLPV
FA
M
L
A
NVS
-
---
G
A
PL
MLT
A
L
A
L
LF
S
NS
Y
GG
M
V
T
H
Y
GGAA
GP
V
I
F
G
V
GY
NDIK
SW
W
LV
GA
VLT
I
L
T
FLV
HI
T
L
G
VW
WW
N
ML
I
GWN
fig|478005.5.peg.1346
Escherichia coli O157:H7 str. EC4486 (1-454/456)
M
P
A
PAGL
SEL
AW
V
L
F
GIY
L
A
A
IVGL
VIK
P
F
P
EP
VV
LL
IAV
A
-
AS
M
-
-
--
---
----
VV
V
G
N
L
SDG
A
FK
T
T
A
V
LSG
Y
SS
G
T
T
WLVF
S
AF
T
L
SA
AFV
T
TGLG
K
RIA
Y
L
L
IG
K
I
G
N
T
TL
G
LGY
V
T
VF
L
DLVLAP
A
TPSNTAR
A
GGIV
L
PII
N
SVAVA
LG
S
E
P
EK
S
P
R
-
R
V
G
H
YLM
MS
IY
M
V
T
KT
TS
Y
MF
F
TAMA
G
N
I
L
A
L
KM
I
ND
I
L
H
L
--
QISWG
G
W
A
L
AA
GL
P
GII
M
LL
V
T
P
LV
I
Y
TM
YPPEIK
KV
D
N
-
K
T
I
A
KA
G
L
AE
L
GP
M
KI
REK
M
LLG
V
F
VLAL
L
G
WIF
S
KSL
-
GV
D
E
S
S
V
A
IV
V
M
A
T
MLL
--
L
G
IV
T
W
E
D
V
V
K
NK
G
G
WNTL
I
W
YG
G
I
I
G
L
S
S
L
L
S
KV
K
F
F
E
W
L
A
EVFKN
N
L
A
F
D
GH
GN
--
V
-
AFF
V
I
I
F
LSI
IV
RYFFAS
G
SAY
I
V
AMLPV
FA
M
L
A
NVS
-
---
G
A
PL
MLT
A
L
A
L
LF
S
NS
Y
GG
M
V
T
H
Y
GGAA
GP
V
I
F
G
V
GY
NDIK
SW
W
LV
GA
VLT
I
L
T
FLV
HI
T
L
G
VW
WW
N
ML
I
GWN
fig|331111.12.peg.1086
Escherichia coli E24377A (13-475/477)
LA
I
PC
II
G
F
M
P
A
PAGL
SEL
AW
V
L
F
GIY
L
A
A
IVGL
VIK
P
F
P
EP
VV
LL
IAV
A
-
AS
M
-
-
--
---
----
VV
V
G
N
L
SDG
A
FK
T
T
A
V
LSG
Y
SS
G
T
T
WLVF
S
AF
T
L
SA
AFV
T
TGLG
K
RIA
Y
L
L
IG
K
I
G
S
T
TL
G
LGY
V
T
VF
L
DLVLAP
A
TPSNTAR
A
GGIV
L
PII
N
SVAVA
LG
S
E
P
EK
S
P
R
-
R
V
G
H
YLM
MS
IY
M
V
T
KT
TS
Y
MF
F
TAMA
G
N
I
L
A
L
KM
I
ND
I
L
H
L
--
QISWG
G
W
A
L
AA
GL
P
GII
M
LL
V
T
P
LV
I
Y
TM
YPPEIK
KV
D
N
-
K
T
I
A
KA
G
L
AE
L
GP
M
KI
REK
M
LLG
V
F
VLAL
L
G
WIF
S
KSL
-
GV
D
E
S
T
V
A
IV
V
M
A
T
MLL
--
L
G
IV
T
W
E
D
V
V
K
NK
G
G
WNTL
I
W
YG
G
I
I
G
L
S
S
L
L
S
KV
K
F
F
E
W
L
A
EVFKN
N
L
A
F
D
GH
GN
--
V
-
AFF
V
I
I
F
LSI
IV
RYFFAS
G
SAY
I
V
AMLPV
FA
M
L
A
NVS
-
---
G
A
PL
MLT
A
L
A
L
LF
S
NS
Y
GG
M
V
T
H
Y
GGAA
GP
V
I
F
G
V
GY
NDIK
SW
W
LV
GA
VLT
I
L
T
FLV
HI
T
L
G
VW
WW
N
ML
I
GWN
fig|331111.3.peg.3305
Escherichia coli E24377A (13-475/477)
LA
I
PC
II
G
F
M
P
A
PAGL
SEL
AW
V
L
F
GIY
L
A
A
IVGL
VIK
P
F
P
EP
VV
LL
IAV
A
-
AS
M
-
-
--
---
----
VV
V
G
N
L
SDG
A
FK
T
T
A
V
LSG
Y
SS
G
T
T
WLVF
S
AF
T
L
SA
AFV
T
TGLG
K
RIA
Y
L
L
IG
K
I
G
S
T
TL
G
LGY
V
T
VF
L
DLVLAP
A
TPSNTAR
A
GGIV
L
PII
N
SVAVA
LG
S
E
P
EK
S
P
R
-
R
V
G
H
YLM
MS
IY
M
V
T
KT
TS
Y
MF
F
TAMA
G
N
I
L
A
L
KM
I
ND
I
L
H
L
--
QISWG
G
W
A
L
AA
GL
P
GII
M
LL
V
T
P
LV
I
Y
TM
YPPEIK
KV
D
N
-
K
T
I
A
KA
G
L
AE
L
GP
M
KI
REK
M
LLG
V
F
VLAL
L
G
WIF
S
KSL
-
GV
D
E
S
T
V
A
IV
V
M
A
T
MLL
--
L
G
IV
T
W
E
D
V
V
K
NK
G
G
WNTL
I
W
YG
G
I
I
G
L
S
S
L
L
S
KV
K
F
F
E
W
L
A
EVFKN
N
L
A
F
D
GH
GN
--
V
-
AFF
V
I
I
F
LSI
IV
RYFFAS
G
SAY
I
V
AMLPV
FA
M
L
A
NVS
-
---
G
A
PL
MLT
A
L
A
L
LF
S
NS
Y
GG
M
V
T
H
Y
GGAA
GP
V
I
F
G
V
GY
NDIK
SW
W
LV
GA
VLT
I
L
T
FLV
HI
T
L
G
VW
WW
N
ML
I
GWN
fig|562.375.peg.1384
Escherichia coli EC4100B (13-475/477)
LA
I
PC
II
G
F
M
P
A
PAGL
SEL
AW
V
L
F
GIY
L
A
A
IVGL
VIK
P
F
P
EP
VV
LL
IAV
A
-
AS
M
-
-
--
---
----
VV
V
G
N
L
SDG
A
FK
T
T
A
V
LSG
Y
SS
G
T
T
WLVF
S
AF
T
L
SA
AFV
T
TGLG
K
RIA
Y
L
L
IG
K
I
G
S
T
TL
G
LGY
V
T
VF
L
DLVLAP
A
TPSNTAR
A
GGIV
L
PII
N
SVAVA
LG
S
E
P
EK
S
P
R
-
R
V
G
H
YLM
MS
IY
M
V
T
KT
TS
Y
MF
F
TAMA
G
N
I
L
A
L
KM
I
ND
I
L
H
L
--
QISWG
G
W
A
L
AA
GL
P
GII
M
LL
V
T
P
LV
I
Y
TM
YPPEIK
KV
D
N
-
K
T
I
A
KA
G
L
AE
L
GP
M
KI
REK
M
LLG
V
F
VLAL
L
G
WIF
S
KSL
-
GV
D
E
S
T
V
A
IV
V
M
A
T
MLL
--
L
G
IV
T
W
E
D
V
V
K
NK
G
G
WNTL
I
W
YG
G
I
I
G
L
S
S
L
L
S
KV
K
F
F
E
W
L
A
EVFKN
N
L
A
F
D
GH
GN
--
V
-
AFF
V
I
I
F
LSI
IV
RYFFAS
G
SAY
I
V
AMLPV
FA
M
L
A
NVS
-
---
G
A
PL
MLT
A
L
A
L
LF
S
NS
Y
GG
M
V
T
H
Y
GGAA
GP
V
I
F
G
V
GY
NDIK
SW
W
LV
GA
VLT
I
L
T
FLV
HI
T
L
G
VW
WW
N
ML
I
GWN
fig|749531.3.peg.1787
Escherichia coli MS 69-1 (13-475/477)
LA
I
PC
II
G
F
M
P
A
PAGL
SEL
AW
V
L
F
GIY
L
A
A
IVGL
VIK
P
F
P
EP
VV
LL
IAV
A
-
AS
M
-
-
--
---
----
VV
V
G
N
L
SDG
A
FK
T
T
A
V
LSG
Y
SS
G
T
T
WLVF
S
AF
T
L
SA
AFV
T
TGLG
K
RIA
Y
L
L
IG
K
I
G
S
T
TL
G
LGY
V
T
VF
L
DLVLAP
A
TPSNTAR
A
GGIV
L
PII
N
SVAVA
LG
S
E
P
EK
S
P
R
-
R
V
G
H
YLM
MS
IY
M
V
T
KT
TS
Y
MF
F
TAMA
G
N
I
L
A
L
KM
I
ND
I
L
H
L
--
QISWG
G
W
A
L
AA
GL
P
GII
M
LL
V
T
P
LV
I
Y
TM
YPPEIK
KV
D
N
-
K
T
I
A
KA
G
L
AE
L
GP
M
KI
REK
M
LLG
V
F
VLAL
L
G
WIF
S
KSL
-
GV
D
E
S
T
V
A
IV
V
M
A
T
MLL
--
L
G
IV
T
W
E
D
V
V
K
NK
G
G
WNTL
I
W
YG
G
I
I
G
L
S
S
L
L
S
KV
K
F
F
E
W
L
A
EVFKN
N
L
A
F
D
GH
GN
--
V
-
AFF
V
I
I
F
LSI
IV
RYFFAS
G
SAY
I
V
AMLPV
FA
M
L
A
NVS
-
---
G
A
PL
MLT
A
L
A
L
LF
S
NS
Y
GG
M
V
T
H
Y
GGAA
GP
V
I
F
G
V
GY
NDIK
SW
W
LV
GA
VLT
I
L
T
FLV
HI
T
L
G
VW
WW
N
ML
I
GWN
fig|409438.11.peg.950
Escherichia coli SE11 (13-475/477)
LA
I
PC
II
G
F
M
P
A
PAGL
SEL
AW
V
L
F
GIY
L
A
A
IVGL
VIK
P
F
P
EP
VV
LL
IAV
A
-
AS
M
-
-
--
---
----
VV
V
G
N
L
SDG
A
FK
T
T
A
V
LSG
Y
SS
G
T
T
WLVF
S
AF
T
L
SA
AFV
T
TGLG
K
RIA
Y
L
L
IG
K
I
G
S
T
TL
G
LGY
V
T
VF
L
DLVLAP
A
TPSNTAR
A
GGIV
L
PII
N
SVAVA
LG
S
E
P
EK
S
P
R
-
R
V
G
H
YLM
MS
IY
M
V
T
KT
TS
Y
MF
F
TAMA
G
N
I
L
A
L
KM
I
ND
I
L
H
L
--
QISWG
G
W
A
L
AA
GL
P
GII
M
LL
V
T
P
LV
I
Y
TM
YPPEIK
KV
D
N
-
K
T
I
A
KA
G
L
AE
L
GP
M
KI
REK
M
LLG
V
F
VLAL
L
G
WIF
S
KSL
-
GV
D
E
S
T
V
A
IV
V
M
A
T
MLL
--
L
G
IV
T
W
E
D
V
V
K
NK
G
G
WNTL
I
W
YG
G
I
I
G
L
S
S
L
L
S
KV
K
F
F
E
W
L
A
EVFKN
N
L
A
F
D
GH
GN
--
V
-
AFF
V
I
I
F
LSI
IV
RYFFAS
G
SAY
I
V
AMLPV
FA
M
L
A
NVS
-
---
G
A
PL
MLT
A
L
A
L
LF
S
NS
Y
GG
M
V
T
H
Y
GGAA
GP
V
I
F
G
V
GY
NDIK
SW
W
LV
GA
VLT
I
L
T
FLV
HI
T
L
G
VW
WW
N
ML
I
GWN
fig|749547.3.peg.1682
Escherichia coli MS 187-1 (13-475/477)
LA
I
PC
II
G
F
M
P
A
PAGL
SEL
AW
V
L
F
GIY
L
A
A
IVGL
VIK
P
F
P
EP
VV
LL
IAV
A
-
AS
M
-
-
--
---
----
VV
V
G
N
L
SDG
A
FK
T
T
A
V
LSG
Y
SS
G
T
N
WLVF
S
AF
T
L
SA
AFV
T
TGLG
K
RIA
Y
L
L
IG
K
I
G
N
T
TL
G
LGY
V
T
VF
L
DLVLAP
A
TPSNTAR
A
GGIV
L
PII
N
SVAVA
LG
S
E
P
EK
S
P
R
-
R
V
G
H
YLM
MS
IY
M
V
T
KT
TS
Y
MF
F
TAMA
G
N
I
L
A
L
KM
I
ND
I
L
H
L
--
QISWG
G
W
A
L
AA
GL
P
GII
M
LL
V
T
P
LV
I
Y
TM
YPPEIK
KV
D
N
-
K
T
I
A
KA
G
L
AE
L
GP
M
KI
REK
M
LLG
V
F
VLAL
L
G
WIF
S
KSL
-
GV
D
E
S
T
V
A
IV
V
M
A
T
MLL
--
L
G
IV
T
W
E
D
V
V
K
NK
G
G
WNTL
I
W
YG
G
I
I
G
L
S
S
L
L
S
KV
K
F
F
E
W
L
A
EVFKN
N
L
A
F
D
GH
GN
--
V
-
AFF
V
I
I
F
LSI
IV
RYFFAS
G
SAY
I
V
AMLPV
FA
M
L
A
NVS
-
---
G
A
PL
MLT
A
L
A
L
LF
S
NS
Y
GG
M
V
T
H
Y
GGAA
GP
V
I
F
G
V
GY
NDIK
SW
W
LV
GA
VLT
I
L
T
FLV
HI
T
L
G
VW
WW
N
ML
I
GWN
fig|316385.5.peg.831
Escherichia coli str. K-12 substr. DH10B (1-454/456)
M
P
A
PAGL
SEL
AW
V
L
F
GIY
L
A
A
IVGL
VIK
P
F
P
EP
VV
LL
IAV
A
-
AS
M
-
-
--
---
----
VV
V
G
N
L
SDG
A
FK
T
T
A
V
LSG
Y
SS
G
T
T
WLVF
S
AF
T
L
SA
AFV
T
TGLG
K
RIA
Y
L
L
IG
K
I
G
N
T
TL
G
LGY
V
T
VF
L
DLVLAP
A
TPSNTAR
A
GGIV
L
PII
N
SVAVA
LG
S
E
P
EK
S
P
R
-
R
V
G
H
YLM
MS
IY
M
V
T
KT
TS
Y
MF
F
TAMA
G
N
I
L
A
L
KM
I
ND
I
L
H
L
--
QISWG
G
W
A
L
AA
GL
P
GII
M
LL
V
T
P
LV
I
Y
TM
YPPEIK
KV
D
N
-
K
T
I
A
KA
G
L
AE
L
GP
M
KI
REK
M
LLG
V
F
VLAL
L
G
WIF
S
KSL
-
GV
D
E
S
T
V
A
IV
V
M
A
T
MLL
--
L
G
IV
T
W
E
D
V
V
K
NK
G
G
WNTL
I
W
YG
G
I
I
G
L
S
S
L
L
S
KV
K
F
F
E
W
L
A
EVFKN
N
L
A
F
D
GH
GN
--
V
-
AFF
V
I
I
F
LSI
IV
RYFFAS
G
SAY
I
V
AMLPV
FA
M
L
A
NVS
-
---
G
A
PL
MLT
A
L
A
L
LF
S
NS
Y
GG
M
V
T
H
Y
GGAA
GP
V
I
F
G
V
GY
NDIK
SW
W
LV
GA
VLT
I
L
T
FLV
HI
T
L
G
VW
WW
N
ML
I
GWN
fig|573235.3.peg.840
Escherichia coli O26:H11 str. 11368 (13-475/477)
LA
I
PC
II
G
F
M
P
A
PAGL
SEL
AW
V
L
F
GIY
L
A
A
IVGL
VIK
P
F
P
EP
VV
LL
IAV
A
-
AS
M
-
-
--
---
----
VV
V
G
N
L
SDG
A
FK
T
T
A
V
LSG
Y
SS
G
T
T
WLVF
S
AF
T
L
SA
AFV
T
TGLG
K
RIA
Y
L
L
IG
K
I
G
N
T
TL
G
LGY
V
T
VF
L
DLVLAP
A
TPSNTAR
A
GGIV
L
PII
N
SVAVA
LG
S
E
P
EK
S
P
R
-
R
V
G
H
YLM
MS
IY
M
V
T
KT
TS
Y
MF
F
TAMA
G
N
I
L
A
L
KM
I
ND
I
L
H
L
--
QISWG
G
W
A
L
AA
GL
P
GII
M
LL
V
T
P
LV
I
Y
TM
YPPEIK
KV
D
N
-
K
T
I
A
KA
G
L
AE
L
GP
M
KI
REK
M
LLG
V
F
VLAL
L
G
WIF
S
KFL
-
GV
D
E
S
T
V
A
IV
V
M
A
T
MLL
--
L
G
IV
T
W
E
D
V
V
K
NK
G
G
WNTL
I
W
YG
G
I
I
G
L
S
S
L
L
S
KV
K
F
F
E
W
L
A
EVFKN
N
L
A
F
D
GH
GN
--
V
-
AFF
V
I
I
F
LSI
IV
RYFFAS
G
SAY
I
V
AMLPV
FA
M
L
A
NVS
-
---
G
A
PL
MLT
A
L
A
L
LF
S
NS
Y
GG
M
V
T
H
Y
GGAA
GP
V
I
F
G
V
GY
NDIK
SW
W
LV
GA
VLT
I
L
T
FLV
HI
T
L
G
VW
WW
N
ML
I
GWN
fig|413997.3.peg.767
Escherichia coli B str. REL606 (13-475/477)
LA
I
PC
II
G
F
M
P
A
PAGL
SEL
AW
V
L
F
GIY
L
A
A
IVGL
VIK
P
F
P
EP
VV
LL
IAV
A
-
AS
M
-
-
--
---
----
VV
V
G
N
L
SDG
A
FK
T
T
A
V
LSG
Y
SS
G
T
T
WLVF
S
AF
T
L
SA
AFV
T
TGLG
T
RIA
Y
L
L
IG
K
I
G
N
T
TL
G
LGY
V
T
VF
L
DLVLAP
A
TPSNTAR
A
GGIV
L
PII
N
SVAVA
LG
S
E
P
EK
S
P
R
-
R
V
G
H
YLM
MS
IY
M
V
T
KT
TS
Y
MF
F
TAMA
G
N
I
L
A
L
KM
I
ND
I
L
H
L
--
QISWG
G
W
A
L
AA
GL
P
GII
M
LL
V
T
P
LV
I
Y
TM
YPPEIK
KV
D
N
-
K
T
I
A
KA
G
L
AE
L
GP
M
KI
REK
M
LLG
V
F
VLAL
L
G
WIF
S
KSL
-
GV
D
E
S
T
V
A
IV
V
M
A
T
MLL
--
L
G
IV
T
W
E
D
V
V
K
NK
G
G
WNTL
I
W
YG
G
I
I
G
L
S
S
L
L
S
KV
K
F
F
E
W
L
A
EVFKN
N
L
A
F
D
GH
GN
--
V
-
AFF
V
I
I
F
LSI
IV
RYFFAS
G
SAY
I
V
AMLPV
FA
M
L
A
NVS
-
---
G
A
PL
MLT
A
L
A
L
LF
S
NS
Y
GG
M
V
T
H
Y
GGAA
GP
V
I
F
G
V
GY
NDIK
SW
W
LV
GA
VLT
I
L
T
FLV
HI
T
L
G
VW
WW
N
ML
I
GWN
fig|478006.5.peg.3765
Escherichia coli O157:H7 str. EC4501 (13-464/471)
LA
I
PC
II
G
F
M
P
A
PAGL
SEL
AW
V
L
F
GIY
L
A
A
IVGL
VIK
P
F
P
EP
VV
LL
IAV
A
-
AS
M
-
-
--
---
----
VV
V
G
N
L
SDG
A
FK
T
T
A
V
LSG
Y
SS
G
T
T
WLVF
S
AF
T
L
SA
AFV
T
TGLG
K
RIA
Y
L
L
IG
K
I
G
N
T
TL
G
LGY
V
T
VF
L
DLVLAP
A
TPSNTAR
A
GGIV
L
PII
N
SVAVA
LG
S
E
P
EK
S
P
R
-
R
V
G
H
YLM
MS
IY
M
V
T
KT
TS
Y
MF
F
TAMA
G
N
I
L
A
L
KM
I
ND
I
L
H
L
--
QISWG
G
W
A
L
AA
GL
P
GII
M
LL
V
T
P
LV
I
Y
TM
YPPEIK
KV
D
N
-
K
T
I
A
KA
G
L
AE
L
GP
M
KI
REK
M
LLG
V
F
VLAL
L
G
WIF
S
KSL
-
GV
D
E
S
S
V
A
IV
V
M
A
T
MLL
--
L
G
IV
T
W
E
D
V
V
K
NK
G
G
WNTL
I
W
YG
G
I
I
G
L
S
S
L
L
S
KV
K
F
F
E
W
L
A
EVFKN
N
L
A
F
D
GH
GN
--
V
-
AFF
V
I
I
F
LSI
IV
RYFFAS
G
SAY
I
V
AMLPV
FA
M
L
A
NVS
-
---
G
A
PL
MLT
A
L
A
L
LF
S
NS
Y
GG
M
V
T
H
Y
GGAA
GP
V
I
F
G
V
GY
NDIK
SW
W
LV
GA
VLT
I
L
T
FLV
HI
T
L
G
fig|502346.5.peg.388
Escherichia coli O157:H7 str. TW14588 (13-464/471)
LA
I
PC
II
G
F
M
P
A
PAGL
SEL
AW
V
L
F
GIY
L
A
A
IVGL
VIK
P
F
P
EP
VV
LL
IAV
A
-
AS
M
-
-
--
---
----
VV
V
G
N
L
SDG
A
FK
T
T
A
V
LSG
Y
SS
G
T
T
WLVF
S
AF
T
L
SA
AFV
T
TGLG
K
RIA
Y
L
L
IG
K
I
G
N
T
TL
G
LGY
V
T
VF
L
DLVLAP
A
TPSNTAR
A
GGIV
L
PII
N
SVAVA
LG
S
E
P
EK
S
P
R
-
R
V
G
H
YLM
MS
IY
M
V
T
KT
TS
Y
MF
F
TAMA
G
N
I
L
A
L
KM
I
ND
I
L
H
L
--
QISWG
G
W
A
L
AA
GL
P
GII
M
LL
V
T
P
LV
I
Y
TM
YPPEIK
KV
D
N
-
K
T
I
A
KA
G
L
AE
L
GP
M
KI
REK
M
LLG
V
F
VLAL
L
G
WIF
S
KSL
-
GV
D
E
S
S
V
A
IV
V
M
A
T
MLL
--
L
G
IV
T
W
E
D
V
V
K
NK
G
G
WNTL
I
W
YG
G
I
I
G
L
S
S
L
L
S
KV
K
F
F
E
W
L
A
EVFKN
N
L
A
F
D
GH
GN
--
V
-
AFF
V
I
I
F
LSI
IV
RYFFAS
G
SAY
I
V
AMLPV
FA
M
L
A
NVS
-
---
G
A
PL
MLT
A
L
A
L
LF
S
NS
Y
GG
M
V
T
H
Y
GGAA
GP
V
I
F
G
V
GY
NDIK
SW
W
LV
GA
VLT
I
L
T
FLV
HI
T
L
G
fig|670897.3.peg.918
Escherichia coli 2362-75 (13-475/477)
LA
I
PC
II
G
F
M
P
A
PAGL
SEL
AW
V
L
F
GIY
L
A
A
IVGL
VIK
P
F
P
EP
VV
LL
IAV
A
-
AS
M
-
-
--
---
----
VV
V
G
N
L
SGG
E
FK
T
T
A
V
LSG
Y
SS
G
T
T
WLVF
S
AF
T
L
SA
AFV
T
TGLG
K
RIA
Y
L
L
IG
K
I
G
S
T
TL
G
LGY
V
T
VF
L
DLVLAP
A
TPSNTAR
A
GGIV
L
PII
N
SVAVA
LG
S
E
P
EK
S
P
R
-
R
V
G
H
YLM
MS
IY
M
V
T
KT
TS
Y
MF
F
TAMA
G
N
I
L
A
L
KM
I
ND
I
L
H
L
--
QISWG
G
W
A
L
AA
GL
P
GII
M
LL
V
T
P
LV
I
Y
TM
YPPEIK
KV
D
N
-
K
T
I
A
KA
G
L
AE
L
GP
M
KI
REK
M
LLG
V
F
VLAL
L
G
WIF
S
KSL
-
GV
D
E
S
T
V
A
IV
V
M
A
T
MLL
--
L
G
IV
T
W
E
D
V
V
K
NK
G
G
WNTL
I
W
YG
G
I
I
G
L
S
S
L
L
S
KV
K
F
F
E
W
L
A
EVFKN
N
L
A
F
D
GH
GN
--
V
-
AFF
V
I
I
F
LSI
IV
RYFFAS
G
SAY
I
V
AMLPV
FA
M
L
A
NVS
-
---
G
A
PL
MLT
A
L
A
L
LF
S
NS
Y
GG
M
V
T
H
Y
GGAA
GP
V
I
F
G
V
GY
NDIK
SW
W
LV
GA
VLT
I
L
T
FLV
HI
T
L
G
VW
WW
N
ML
I
GWN
fig|362663.8.peg.788
Escherichia coli 536 (13-475/477)
LA
I
PC
II
G
F
M
P
A
PAGL
SEL
AW
V
L
F
GIY
L
A
A
IVGL
VIK
P
F
P
EP
VV
LL
IAV
A
-
AS
M
-
-
--
---
----
VV
V
G
N
L
SGG
E
FK
T
T
A
V
LSG
Y
SS
G
T
T
WLVF
S
AF
T
L
SA
AFV
T
TGLG
K
RIA
Y
L
L
IG
K
I
G
S
T
TL
G
LGY
V
T
VF
L
DLVLAP
A
TPSNTAR
A
GGIV
L
PII
N
SVAVA
LG
S
E
P
EK
S
P
R
-
R
V
G
H
YLM
MS
IY
M
V
T
KT
TS
Y
MF
F
TAMA
G
N
I
L
A
L
KM
I
ND
I
L
H
L
--
QISWG
G
W
A
L
AA
GL
P
GII
M
LL
V
T
P
LV
I
Y
TM
YPPEIK
KV
D
N
-
K
T
I
A
KA
G
L
AE
L
GP
M
KI
REK
M
LLG
V
F
VLAL
L
G
WIF
S
KSL
-
GV
D
E
S
T
V
A
IV
V
M
A
T
MLL
--
L
G
IV
T
W
E
D
V
V
K
NK
G
G
WNTL
I
W
YG
G
I
I
G
L
S
S
L
L
S
KV
K
F
F
E
W
L
A
EVFKN
N
L
A
F
D
GH
GN
--
V
-
AFF
V
I
I
F
LSI
IV
RYFFAS
G
SAY
I
V
AMLPV
FA
M
L
A
NVS
-
---
G
A
PL
MLT
A
L
A
L
LF
S
NS
Y
GG
M
V
T
H
Y
GGAA
GP
V
I
F
G
V
GY
NDIK
SW
W
LV
GA
VLT
I
L
T
FLV
HI
T
L
G
VW
WW
N
ML
I
GWN
fig|362663.9.peg.788
Escherichia coli 536 (13-475/477)
LA
I
PC
II
G
F
M
P
A
PAGL
SEL
AW
V
L
F
GIY
L
A
A
IVGL
VIK
P
F
P
EP
VV
LL
IAV
A
-
AS
M
-
-
--
---
----
VV
V
G
N
L
SGG
E
FK
T
T
A
V
LSG
Y
SS
G
T
T
WLVF
S
AF
T
L
SA
AFV
T
TGLG
K
RIA
Y
L
L
IG
K
I
G
S
T
TL
G
LGY
V
T
VF
L
DLVLAP
A
TPSNTAR
A
GGIV
L
PII
N
SVAVA
LG
S
E
P
EK
S
P
R
-
R
V
G
H
YLM
MS
IY
M
V
T
KT
TS
Y
MF
F
TAMA
G
N
I
L
A
L
KM
I
ND
I
L
H
L
--
QISWG
G
W
A
L
AA
GL
P
GII
M
LL
V
T
P
LV
I
Y
TM
YPPEIK
KV
D
N
-
K
T
I
A
KA
G
L
AE
L
GP
M
KI
REK
M
LLG
V
F
VLAL
L
G
WIF
S
KSL
-
GV
D
E
S
T
V
A
IV
V
M
A
T
MLL
--
L
G
IV
T
W
E
D
V
V
K
NK
G
G
WNTL
I
W
YG
G
I
I
G
L
S
S
L
L
S
KV
K
F
F
E
W
L
A
EVFKN
N
L
A
F
D
GH
GN
--
V
-
AFF
V
I
I
F
LSI
IV
RYFFAS
G
SAY
I
V
AMLPV
FA
M
L
A
NVS
-
---
G
A
PL
MLT
A
L
A
L
LF
S
NS
Y
GG
M
V
T
H
Y
GGAA
GP
V
I
F
G
V
GY
NDIK
SW
W
LV
GA
VLT
I
L
T
FLV
HI
T
L
G
VW
WW
N
ML
I
GWN
fig|525281.3.peg.2186
Escherichia coli 83972 (13-475/477)
LA
I
PC
II
G
F
M
P
A
PAGL
SEL
AW
V
L
F
GIY
L
A
A
IVGL
VIK
P
F
P
EP
VV
LL
IAV
A
-
AS
M
-
-
--
---
----
VV
V
G
N
L
SGG
E
FK
T
T
A
V
LSG
Y
SS
G
T
T
WLVF
S
AF
T
L
SA
AFV
T
TGLG
K
RIA
Y
L
L
IG
K
I
G
S
T
TL
G
LGY
V
T
VF
L
DLVLAP
A
TPSNTAR
A
GGIV
L
PII
N
SVAVA
LG
S
E
P
EK
S
P
R
-
R
V
G
H
YLM
MS
IY
M
V
T
KT
TS
Y
MF
F
TAMA
G
N
I
L
A
L
KM
I
ND
I
L
H
L
--
QISWG
G
W
A
L
AA
GL
P
GII
M
LL
V
T
P
LV
I
Y
TM
YPPEIK
KV
D
N
-
K
T
I
A
KA
G
L
AE
L
GP
M
KI
REK
M
LLG
V
F
VLAL
L
G
WIF
S
KSL
-
GV
D
E
S
T
V
A
IV
V
M
A
T
MLL
--
L
G
IV
T
W
E
D
V
V
K
NK
G
G
WNTL
I
W
YG
G
I
I
G
L
S
S
L
L
S
KV
K
F
F
E
W
L
A
EVFKN
N
L
A
F
D
GH
GN
--
V
-
AFF
V
I
I
F
LSI
IV
RYFFAS
G
SAY
I
V
AMLPV
FA
M
L
A
NVS
-
---
G
A
PL
MLT
A
L
A
L
LF
S
NS
Y
GG
M
V
T
H
Y
GGAA
GP
V
I
F
G
V
GY
NDIK
SW
W
LV
GA
VLT
I
L
T
FLV
HI
T
L
G
VW
WW
N
ML
I
GWN
fig|655817.3.peg.852
Escherichia coli ABU 83972 (13-475/477)
LA
I
PC
II
G
F
M
P
A
PAGL
SEL
AW
V
L
F
GIY
L
A
A
IVGL
VIK
P
F
P
EP
VV
LL
IAV
A
-
AS
M
-
-
--
---
----
VV
V
G
N
L
SGG
E
FK
T
T
A
V
LSG
Y
SS
G
T
T
WLVF
S
AF
T
L
SA
AFV
T
TGLG
K
RIA
Y
L
L
IG
K
I
G
S
T
TL
G
LGY
V
T
VF
L
DLVLAP
A
TPSNTAR
A
GGIV
L
PII
N
SVAVA
LG
S
E
P
EK
S
P
R
-
R
V
G
H
YLM
MS
IY
M
V
T
KT
TS
Y
MF
F
TAMA
G
N
I
L
A
L
KM
I
ND
I
L
H
L
--
QISWG
G
W
A
L
AA
GL
P
GII
M
LL
V
T
P
LV
I
Y
TM
YPPEIK
KV
D
N
-
K
T
I
A
KA
G
L
AE
L
GP
M
KI
REK
M
LLG
V
F
VLAL
L
G
WIF
S
KSL
-
GV
D
E
S
T
V
A
IV
V
M
A
T
MLL
--
L
G
IV
T
W
E
D
V
V
K
NK
G
G
WNTL
I
W
YG
G
I
I
G
L
S
S
L
L
S
KV
K
F
F
E
W
L
A
EVFKN
N
L
A
F
D
GH
GN
--
V
-
AFF
V
I
I
F
LSI
IV
RYFFAS
G
SAY
I
V
AMLPV
FA
M
L
A
NVS
-
---
G
A
PL
MLT
A
L
A
L
LF
S
NS
Y
GG
M
V
T
H
Y
GGAA
GP
V
I
F
G
V
GY
NDIK
SW
W
LV
GA
VLT
I
L
T
FLV
HI
T
L
G
VW
WW
N
ML
I
GWN
fig|405955.13.peg.727
Escherichia coli APEC O1 (13-475/477)
LA
I
PC
II
G
F
M
P
A
PAGL
SEL
AW
V
L
F
GIY
L
A
A
IVGL
VIK
P
F
P
EP
VV
LL
IAV
A
-
AS
M
-
-
--
---
----
VV
V
G
N
L
SGG
E
FK
T
T
A
V
LSG
Y
SS
G
T
T
WLVF
S
AF
T
L
SA
AFV
T
TGLG
K
RIA
Y
L
L
IG
K
I
G
S
T
TL
G
LGY
V
T
VF
L
DLVLAP
A
TPSNTAR
A
GGIV
L
PII
N
SVAVA
LG
S
E
P
EK
S
P
R
-
R
V
G
H
YLM
MS
IY
M
V
T
KT
TS
Y
MF
F
TAMA
G
N
I
L
A
L
KM
I
ND
I
L
H
L
--
QISWG
G
W
A
L
AA
GL
P
GII
M
LL
V
T
P
LV
I
Y
TM
YPPEIK
KV
D
N
-
K
T
I
A
KA
G
L
AE
L
GP
M
KI
REK
M
LLG
V
F
VLAL
L
G
WIF
S
KSL
-
GV
D
E
S
T
V
A
IV
V
M
A
T
MLL
--
L
G
IV
T
W
E
D
V
V
K
NK
G
G
WNTL
I
W
YG
G
I
I
G
L
S
S
L
L
S
KV
K
F
F
E
W
L
A
EVFKN
N
L
A
F
D
GH
GN
--
V
-
AFF
V
I
I
F
LSI
IV
RYFFAS
G
SAY
I
V
AMLPV
FA
M
L
A
NVS
-
---
G
A
PL
MLT
A
L
A
L
LF
S
NS
Y
GG
M
V
T
H
Y
GGAA
GP
V
I
F
G
V
GY
NDIK
SW
W
LV
GA
VLT
I
L
T
FLV
HI
T
L
G
VW
WW
N
ML
I
GWN
fig|405955.9.peg.608
Escherichia coli APEC O1 (13-475/477)
LA
I
PC
II
G
F
M
P
A
PAGL
SEL
AW
V
L
F
GIY
L
A
A
IVGL
VIK
P
F
P
EP
VV
LL
IAV
A
-
AS
M
-
-
--
---
----
VV
V
G
N
L
SGG
E
FK
T
T
A
V
LSG
Y
SS
G
T
T
WLVF
S
AF
T
L
SA
AFV
T
TGLG
K
RIA
Y
L
L
IG
K
I
G
S
T
TL
G
LGY
V
T
VF
L
DLVLAP
A
TPSNTAR
A
GGIV
L
PII
N
SVAVA
LG
S
E
P
EK
S
P
R
-
R
V
G
H
YLM
MS
IY
M
V
T
KT
TS
Y
MF
F
TAMA
G
N
I
L
A
L
KM
I
ND
I
L
H
L
--
QISWG
G
W
A
L
AA
GL
P
GII
M
LL
V
T
P
LV
I
Y
TM
YPPEIK
KV
D
N
-
K
T
I
A
KA
G
L
AE
L
GP
M
KI
REK
M
LLG
V
F
VLAL
L
G
WIF
S
KSL
-
GV
D
E
S
T
V
A
IV
V
M
A
T
MLL
--
L
G
IV
T
W
E
D
V
V
K
NK
G
G
WNTL
I
W
YG
G
I
I
G
L
S
S
L
L
S
KV
K
F
F
E
W
L
A
EVFKN
N
L
A
F
D
GH
GN
--
V
-
AFF
V
I
I
F
LSI
IV
RYFFAS
G
SAY
I
V
AMLPV
FA
M
L
A
NVS
-
---
G
A
PL
MLT
A
L
A
L
LF
S
NS
Y
GG
M
V
T
H
Y
GGAA
GP
V
I
F
G
V
GY
NDIK
SW
W
LV
GA
VLT
I
L
T
FLV
HI
T
L
G
VW
WW
N
ML
I
GWN
fig|199310.1.peg.820
Escherichia coli CFT073 (13-475/477)
LA
I
PC
II
G
F
M
P
A
PAGL
SEL
AW
V
L
F
GIY
L
A
A
IVGL
VIK
P
F
P
EP
VV
LL
IAV
A
-
AS
M
-
-
--
---
----
VV
V
G
N
L
SGG
E
FK
T
T
A
V
LSG
Y
SS
G
T
T
WLVF
S
AF
T
L
SA
AFV
T
TGLG
K
RIA
Y
L
L
IG
K
I
G
S
T
TL
G
LGY
V
T
VF
L
DLVLAP
A
TPSNTAR
A
GGIV
L
PII
N
SVAVA
LG
S
E
P
EK
S
P
R
-
R
V
G
H
YLM
MS
IY
M
V
T
KT
TS
Y
MF
F
TAMA
G
N
I
L
A
L
KM
I
ND
I
L
H
L
--
QISWG
G
W
A
L
AA
GL
P
GII
M
LL
V
T
P
LV
I
Y
TM
YPPEIK
KV
D
N
-
K
T
I
A
KA
G
L
AE
L
GP
M
KI
REK
M
LLG
V
F
VLAL
L
G
WIF
S
KSL
-
GV
D
E
S
T
V
A
IV
V
M
A
T
MLL
--
L
G
IV
T
W
E
D
V
V
K
NK
G
G
WNTL
I
W
YG
G
I
I
G
L
S
S
L
L
S
KV
K
F
F
E
W
L
A
EVFKN
N
L
A
F
D
GH
GN
--
V
-
AFF
V
I
I
F
LSI
IV
RYFFAS
G
SAY
I
V
AMLPV
FA
M
L
A
NVS
-
---
G
A
PL
MLT
A
L
A
L
LF
S
NS
Y
GG
M
V
T
H
Y
GGAA
GP
V
I
F
G
V
GY
NDIK
SW
W
LV
GA
VLT
I
L
T
FLV
HI
T
L
G
VW
WW
N
ML
I
GWN
fig|199310.4.peg.806
Escherichia coli CFT073 (13-475/477)
LA
I
PC
II
G
F
M
P
A
PAGL
SEL
AW
V
L
F
GIY
L
A
A
IVGL
VIK
P
F
P
EP
VV
LL
IAV
A
-
AS
M
-
-
--
---
----
VV
V
G
N
L
SGG
E
FK
T
T
A
V
LSG
Y
SS
G
T
T
WLVF
S
AF
T
L
SA
AFV
T
TGLG
K
RIA
Y
L
L
IG
K
I
G
S
T
TL
G
LGY
V
T
VF
L
DLVLAP
A
TPSNTAR
A
GGIV
L
PII
N
SVAVA
LG
S
E
P
EK
S
P
R
-
R
V
G
H
YLM
MS
IY
M
V
T
KT
TS
Y
MF
F
TAMA
G
N
I
L
A
L
KM
I
ND
I
L
H
L
--
QISWG
G
W
A
L
AA
GL
P
GII
M
LL
V
T
P
LV
I
Y
TM
YPPEIK
KV
D
N
-
K
T
I
A
KA
G
L
AE
L
GP
M
KI
REK
M
LLG
V
F
VLAL
L
G
WIF
S
KSL
-
GV
D
E
S
T
V
A
IV
V
M
A
T
MLL
--
L
G
IV
T
W
E
D
V
V
K
NK
G
G
WNTL
I
W
YG
G
I
I
G
L
S
S
L
L
S
KV
K
F
F
E
W
L
A
EVFKN
N
L
A
F
D
GH
GN
--
V
-
AFF
V
I
I
F
LSI
IV
RYFFAS
G
SAY
I
V
AMLPV
FA
M
L
A
NVS
-
---
G
A
PL
MLT
A
L
A
L
LF
S
NS
Y
GG
M
V
T
H
Y
GGAA
GP
V
I
F
G
V
GY
NDIK
SW
W
LV
GA
VLT
I
L
T
FLV
HI
T
L
G
VW
WW
N
ML
I
GWN
fig|585397.7.peg.741
Escherichia coli ED1a (13-475/477)
LA
I
PC
II
G
F
M
P
A
PAGL
SEL
AW
V
L
F
GIY
L
A
A
IVGL
VIK
P
F
P
EP
VV
LL
IAV
A
-
AS
M
-
-
--
---
----
VV
V
G
N
L
SGG
E
FK
T
T
A
V
LSG
Y
SS
G
T
T
WLVF
S
AF
T
L
SA
AFV
T
TGLG
K
RIA
Y
L
L
IG
K
I
G
S
T
TL
G
LGY
V
T
VF
L
DLVLAP
A
TPSNTAR
A
GGIV
L
PII
N
SVAVA
LG
S
E
P
EK
S
P
R
-
R
V
G
H
YLM
MS
IY
M
V
T
KT
TS
Y
MF
F
TAMA
G
N
I
L
A
L
KM
I
ND
I
L
H
L
--
QISWG
G
W
A
L
AA
GL
P
GII
M
LL
V
T
P
LV
I
Y
TM
YPPEIK
KV
D
N
-
K
T
I
A
KA
G
L
AE
L
GP
M
KI
REK
M
LLG
V
F
VLAL
L
G
WIF
S
KSL
-
GV
D
E
S
T
V
A
IV
V
M
A
T
MLL
--
L
G
IV
T
W
E
D
V
V
K
NK
G
G
WNTL
I
W
YG
G
I
I
G
L
S
S
L
L
S
KV
K
F
F
E
W
L
A
EVFKN
N
L
A
F
D
GH
GN
--
V
-
AFF
V
I
I
F
LSI
IV
RYFFAS
G
SAY
I
V
AMLPV
FA
M
L
A
NVS
-
---
G
A
PL
MLT
A
L
A
L
LF
S
NS
Y
GG
M
V
T
H
Y
GGAA
GP
V
I
F
G
V
GY
NDIK
SW
W
LV
GA
VLT
I
L
T
FLV
HI
T
L
G
VW
WW
N
ML
I
GWN
fig|585397.9.peg.741
Escherichia coli ED1a (13-475/477)
LA
I
PC
II
G
F
M
P
A
PAGL
SEL
AW
V
L
F
GIY
L
A
A
IVGL
VIK
P
F
P
EP
VV
LL
IAV
A
-
AS
M
-
-
--
---
----
VV
V
G
N
L
SGG
E
FK
T
T
A
V
LSG
Y
SS
G
T
T
WLVF
S
AF
T
L
SA
AFV
T
TGLG
K
RIA
Y
L
L
IG
K
I
G
S
T
TL
G
LGY
V
T
VF
L
DLVLAP
A
TPSNTAR
A
GGIV
L
PII
N
SVAVA
LG
S
E
P
EK
S
P
R
-
R
V
G
H
YLM
MS
IY
M
V
T
KT
TS
Y
MF
F
TAMA
G
N
I
L
A
L
KM
I
ND
I
L
H
L
--
QISWG
G
W
A
L
AA
GL
P
GII
M
LL
V
T
P
LV
I
Y
TM
YPPEIK
KV
D
N
-
K
T
I
A
KA
G
L
AE
L
GP
M
KI
REK
M
LLG
V
F
VLAL
L
G
WIF
S
KSL
-
GV
D
E
S
T
V
A
IV
V
M
A
T
MLL
--
L
G
IV
T
W
E
D
V
V
K
NK
G
G
WNTL
I
W
YG
G
I
I
G
L
S
S
L
L
S
KV
K
F
F
E
W
L
A
EVFKN
N
L
A
F
D
GH
GN
--
V
-
AFF
V
I
I
F
LSI
IV
RYFFAS
G
SAY
I
V
AMLPV
FA
M
L
A
NVS
-
---
G
A
PL
MLT
A
L
A
L
LF
S
NS
Y
GG
M
V
T
H
Y
GGAA
GP
V
I
F
G
V
GY
NDIK
SW
W
LV
GA
VLT
I
L
T
FLV
HI
T
L
G
VW
WW
N
ML
I
GWN
fig|340197.3.peg.4319
Escherichia coli F11 (13-475/477)
LA
I
PC
II
G
F
M
P
A
PAGL
SEL
AW
V
L
F
GIY
L
A
A
IVGL
VIK
P
F
P
EP
VV
LL
IAV
A
-
AS
M
-
-
--
---
----
VV
V
G
N
L
SGG
E
FK
T
T
A
V
LSG
Y
SS
G
T
T
WLVF
S
AF
T
L
SA
AFV
T
TGLG
K
RIA
Y
L
L
IG
K
I
G
S
T
TL
G
LGY
V
T
VF
L
DLVLAP
A
TPSNTAR
A
GGIV
L
PII
N
SVAVA
LG
S
E
P
EK
S
P
R
-
R
V
G
H
YLM
MS
IY
M
V
T
KT
TS
Y
MF
F
TAMA
G
N
I
L
A
L
KM
I
ND
I
L
H
L
--
QISWG
G
W
A
L
AA
GL
P
GII
M
LL
V
T
P
LV
I
Y
TM
YPPEIK
KV
D
N
-
K
T
I
A
KA
G
L
AE
L
GP
M
KI
REK
M
LLG
V
F
VLAL
L
G
WIF
S
KSL
-
GV
D
E
S
T
V
A
IV
V
M
A
T
MLL
--
L
G
IV
T
W
E
D
V
V
K
NK
G
G
WNTL
I
W
YG
G
I
I
G
L
S
S
L
L
S
KV
K
F
F
E
W
L
A
EVFKN
N
L
A
F
D
GH
GN
--
V
-
AFF
V
I
I
F
LSI
IV
RYFFAS
G
SAY
I
V
AMLPV
FA
M
L
A
NVS
-
---
G
A
PL
MLT
A
L
A
L
LF
S
NS
Y
GG
M
V
T
H
Y
GGAA
GP
V
I
F
G
V
GY
NDIK
SW
W
LV
GA
VLT
I
L
T
FLV
HI
T
L
G
VW
WW
N
ML
I
GWN
fig|340197.5.peg.4510
Escherichia coli F11 (13-475/477)
LA
I
PC
II
G
F
M
P
A
PAGL
SEL
AW
V
L
F
GIY
L
A
A
IVGL
VIK
P
F
P
EP
VV
LL
IAV
A
-
AS
M
-
-
--
---
----
VV
V
G
N
L
SGG
E
FK
T
T
A
V
LSG
Y
SS
G
T
T
WLVF
S
AF
T
L
SA
AFV
T
TGLG
K
RIA
Y
L
L
IG
K
I
G
S
T
TL
G
LGY
V
T
VF
L
DLVLAP
A
TPSNTAR
A
GGIV
L
PII
N
SVAVA
LG
S
E
P
EK
S
P
R
-
R
V
G
H
YLM
MS
IY
M
V
T
KT
TS
Y
MF
F
TAMA
G
N
I
L
A
L
KM
I
ND
I
L
H
L
--
QISWG
G
W
A
L
AA
GL
P
GII
M
LL
V
T
P
LV
I
Y
TM
YPPEIK
KV
D
N
-
K
T
I
A
KA
G
L
AE
L
GP
M
KI
REK
M
LLG
V
F
VLAL
L
G
WIF
S
KSL
-
GV
D
E
S
T
V
A
IV
V
M
A
T
MLL
--
L
G
IV
T
W
E
D
V
V
K
NK
G
G
WNTL
I
W
YG
G
I
I
G
L
S
S
L
L
S
KV
K
F
F
E
W
L
A
EVFKN
N
L
A
F
D
GH
GN
--
V
-
AFF
V
I
I
F
LSI
IV
RYFFAS
G
SAY
I
V
AMLPV
FA
M
L
A
NVS
-
---
G
A
PL
MLT
A
L
A
L
LF
S
NS
Y
GG
M
V
T
H
Y
GGAA
GP
V
I
F
G
V
GY
NDIK
SW
W
LV
GA
VLT
I
L
T
FLV
HI
T
L
G
VW
WW
N
ML
I
GWN
fig|656393.3.peg.1451
Escherichia coli H299 (13-475/477)
LA
I
PC
II
G
F
M
P
A
PAGL
SEL
AW
V
L
F
GIY
L
A
A
IVGL
VIK
P
F
P
EP
VV
LL
IAV
A
-
AS
M
-
-
--
---
----
VV
V
G
N
L
SGG
E
FK
T
T
A
V
LSG
Y
SS
G
T
T
WLVF
S
AF
T
L
SA
AFV
T
TGLG
K
RIA
Y
L
L
IG
K
I
G
S
T
TL
G
LGY
V
T
VF
L
DLVLAP
A
TPSNTAR
A
GGIV
L
PII
N
SVAVA
LG
S
E
P
EK
S
P
R
-
R
V
G
H
YLM
MS
IY
M
V
T
KT
TS
Y
MF
F
TAMA
G
N
I
L
A
L
KM
I
ND
I
L
H
L
--
QISWG
G
W
A
L
AA
GL
P
GII
M
LL
V
T
P
LV
I
Y
TM
YPPEIK
KV
D
N
-
K
T
I
A
KA
G
L
AE
L
GP
M
KI
REK
M
LLG
V
F
VLAL
L
G
WIF
S
KSL
-
GV
D
E
S
T
V
A
IV
V
M
A
T
MLL
--
L
G
IV
T
W
E
D
V
V
K
NK
G
G
WNTL
I
W
YG
G
I
I
G
L
S
S
L
L
S
KV
K
F
F
E
W
L
A
EVFKN
N
L
A
F
D
GH
GN
--
V
-
AFF
V
I
I
F
LSI
IV
RYFFAS
G
SAY
I
V
AMLPV
FA
M
L
A
NVS
-
---
G
A
PL
MLT
A
L
A
L
LF
S
NS
Y
GG
M
V
T
H
Y
GGAA
GP
V
I
F
G
V
GY
NDIK
SW
W
LV
GA
VLT
I
L
T
FLV
HI
T
L
G
VW
WW
N
ML
I
GWN
fig|714962.3.peg.775
Escherichia coli IHE3034 (13-475/477)
LA
I
PC
II
G
F
M
P
A
PAGL
SEL
AW
V
L
F
GIY
L
A
A
IVGL
VIK
P
F
P
EP
VV
LL
IAV
A
-
AS
M
-
-
--
---
----
VV
V
G
N
L
SGG
E
FK
T
T
A
V
LSG
Y
SS
G
T
T
WLVF
S
AF
T
L
SA
AFV
T
TGLG
K
RIA
Y
L
L
IG
K
I
G
S
T
TL
G
LGY
V
T
VF
L
DLVLAP
A
TPSNTAR
A
GGIV
L
PII
N
SVAVA
LG
S
E
P
EK
S
P
R
-
R
V
G
H
YLM
MS
IY
M
V
T
KT
TS
Y
MF
F
TAMA
G
N
I
L
A
L
KM
I
ND
I
L
H
L
--
QISWG
G
W
A
L
AA
GL
P
GII
M
LL
V
T
P
LV
I
Y
TM
YPPEIK
KV
D
N
-
K
T
I
A
KA
G
L
AE
L
GP
M
KI
REK
M
LLG
V
F
VLAL
L
G
WIF
S
KSL
-
GV
D
E
S
T
V
A
IV
V
M
A
T
MLL
--
L
G
IV
T
W
E
D
V
V
K
NK
G
G
WNTL
I
W
YG
G
I
I
G
L
S
S
L
L
S
KV
K
F
F
E
W
L
A
EVFKN
N
L
A
F
D
GH
GN
--
V
-
AFF
V
I
I
F
LSI
IV
RYFFAS
G
SAY
I
V
AMLPV
FA
M
L
A
NVS
-
---
G
A
PL
MLT
A
L
A
L
LF
S
NS
Y
GG
M
V
T
H
Y
GGAA
GP
V
I
F
G
V
GY
NDIK
SW
W
LV
GA
VLT
I
L
T
FLV
HI
T
L
G
VW
WW
N
ML
I
GWN
fig|656417.3.peg.895
Escherichia coli M605 (13-475/477)
LA
I
PC
II
G
F
M
P
A
PAGL
SEL
AW
V
L
F
GIY
L
A
A
IVGL
VIK
P
F
P
EP
VV
LL
IAV
A
-
AS
M
-
-
--
---
----
VV
V
G
N
L
SGG
E
FK
T
T
A
V
LSG
Y
SS
G
T
T
WLVF
S
AF
T
L
SA
AFV
T
TGLG
K
RIA
Y
L
L
IG
K
I
G
S
T
TL
G
LGY
V
T
VF
L
DLVLAP
A
TPSNTAR
A
GGIV
L
PII
N
SVAVA
LG
S
E
P
EK
S
P
R
-
R
V
G
H
YLM
MS
IY
M
V
T
KT
TS
Y
MF
F
TAMA
G
N
I
L
A
L
KM
I
ND
I
L
H
L
--
QISWG
G
W
A
L
AA
GL
P
GII
M
LL
V
T
P
LV
I
Y
TM
YPPEIK
KV
D
N
-
K
T
I
A
KA
G
L
AE
L
GP
M
KI
REK
M
LLG
V
F
VLAL
L
G
WIF
S
KSL
-
GV
D
E
S
T
V
A
IV
V
M
A
T
MLL
--
L
G
IV
T
W
E
D
V
V
K
NK
G
G
WNTL
I
W
YG
G
I
I
G
L
S
S
L
L
S
KV
K
F
F
E
W
L
A
EVFKN
N
L
A
F
D
GH
GN
--
V
-
AFF
V
I
I
F
LSI
IV
RYFFAS
G
SAY
I
V
AMLPV
FA
M
L
A
NVS
-
---
G
A
PL
MLT
A
L
A
L
LF
S
NS
Y
GG
M
V
T
H
Y
GGAA
GP
V
I
F
G
V
GY
NDIK
SW
W
LV
GA
VLT
I
L
T
FLV
HI
T
L
G
VW
WW
N
ML
I
GWN
fig|749546.3.peg.4742
Escherichia coli MS 185-1 (13-475/477)
LA
I
PC
II
G
F
M
P
A
PAGL
SEL
AW
V
L
F
GIY
L
A
A
IVGL
VIK
P
F
P
EP
VV
LL
IAV
A
-
AS
M
-
-
--
---
----
VV
V
G
N
L
SGG
E
FK
T
T
A
V
LSG
Y
SS
G
T
T
WLVF
S
AF
T
L
SA
AFV
T
TGLG
K
RIA
Y
L
L
IG
K
I
G
S
T
TL
G
LGY
V
T
VF
L
DLVLAP
A
TPSNTAR
A
GGIV
L
PII
N
SVAVA
LG
S
E
P
EK
S
P
R
-
R
V
G
H
YLM
MS
IY
M
V
T
KT
TS
Y
MF
F
TAMA
G
N
I
L
A
L
KM
I
ND
I
L
H
L
--
QISWG
G
W
A
L
AA
GL
P
GII
M
LL
V
T
P
LV
I
Y
TM
YPPEIK
KV
D
N
-
K
T
I
A
KA
G
L
AE
L
GP
M
KI
REK
M
LLG
V
F
VLAL
L
G
WIF
S
KSL
-
GV
D
E
S
T
V
A
IV
V
M
A
T
MLL
--
L
G
IV
T
W
E
D
V
V
K
NK
G
G
WNTL
I
W
YG
G
I
I
G
L
S
S
L
L
S
KV
K
F
F
E
W
L
A
EVFKN
N
L
A
F
D
GH
GN
--
V
-
AFF
V
I
I
F
LSI
IV
RYFFAS
G
SAY
I
V
AMLPV
FA
M
L
A
NVS
-
---
G
A
PL
MLT
A
L
A
L
LF
S
NS
Y
GG
M
V
T
H
Y
GGAA
GP
V
I
F
G
V
GY
NDIK
SW
W
LV
GA
VLT
I
L
T
FLV
HI
T
L
G
VW
WW
N
ML
I
GWN
fig|749550.3.peg.3803
Escherichia coli MS 200-1 (13-475/477)
LA
I
PC
II
G
F
M
P
A
PAGL
SEL
AW
V
L
F
GIY
L
A
A
IVGL
VIK
P
F
P
EP
VV
LL
IAV
A
-
AS
M
-
-
--
---
----
VV
V
G
N
L
SGG
E
FK
T
T
A
V
LSG
Y
SS
G
T
T
WLVF
S
AF
T
L
SA
AFV
T
TGLG
K
RIA
Y
L
L
IG
K
I
G
S
T
TL
G
LGY
V
T
VF
L
DLVLAP
A
TPSNTAR
A
GGIV
L
PII
N
SVAVA
LG
S
E
P
EK
S
P
R
-
R
V
G
H
YLM
MS
IY
M
V
T
KT
TS
Y
MF
F
TAMA
G
N
I
L
A
L
KM
I
ND
I
L
H
L
--
QISWG
G
W
A
L
AA
GL
P
GII
M
LL
V
T
P
LV
I
Y
TM
YPPEIK
KV
D
N
-
K
T
I
A
KA
G
L
AE
L
GP
M
KI
REK
M
LLG
V
F
VLAL
L
G
WIF
S
KSL
-
GV
D
E
S
T
V
A
IV
V
M
A
T
MLL
--
L
G
IV
T
W
E
D
V
V
K
NK
G
G
WNTL
I
W
YG
G
I
I
G
L
S
S
L
L
S
KV
K
F
F
E
W
L
A
EVFKN
N
L
A
F
D
GH
GN
--
V
-
AFF
V
I
I
F
LSI
IV
RYFFAS
G
SAY
I
V
AMLPV
FA
M
L
A
NVS
-
---
G
A
PL
MLT
A
L
A
L
LF
S
NS
Y
GG
M
V
T
H
Y
GGAA
GP
V
I
F
G
V
GY
NDIK
SW
W
LV
GA
VLT
I
L
T
FLV
HI
T
L
G
VW
WW
N
ML
I
GWN
fig|749528.3.peg.4504
Escherichia coli MS 45-1 (13-475/477)
LA
I
PC
II
G
F
M
P
A
PAGL
SEL
AW
V
L
F
GIY
L
A
A
IVGL
VIK
P
F
P
EP
VV
LL
IAV
A
-
AS
M
-
-
--
---
----
VV
V
G
N
L
SGG
E
FK
T
T
A
V
LSG
Y
SS
G
T
T
WLVF
S
AF
T
L
SA
AFV
T
TGLG
K
RIA
Y
L
L
IG
K
I
G
S
T
TL
G
LGY
V
T
VF
L
DLVLAP
A
TPSNTAR
A
GGIV
L
PII
N
SVAVA
LG
S
E
P
EK
S
P
R
-
R
V
G
H
YLM
MS
IY
M
V
T
KT
TS
Y
MF
F
TAMA
G
N
I
L
A
L
KM
I
ND
I
L
H
L
--
QISWG
G
W
A
L
AA
GL
P
GII
M
LL
V
T
P
LV
I
Y
TM
YPPEIK
KV
D
N
-
K
T
I
A
KA
G
L
AE
L
GP
M
KI
REK
M
LLG
V
F
VLAL
L
G
WIF
S
KSL
-
GV
D
E
S
T
V
A
IV
V
M
A
T
MLL
--
L
G
IV
T
W
E
D
V
V
K
NK
G
G
WNTL
I
W
YG
G
I
I
G
L
S
S
L
L
S
KV
K
F
F
E
W
L
A
EVFKN
N
L
A
F
D
GH
GN
--
V
-
AFF
V
I
I
F
LSI
IV
RYFFAS
G
SAY
I
V
AMLPV
FA
M
L
A
NVS
-
---
G
A
PL
MLT
A
L
A
L
LF
S
NS
Y
GG
M
V
T
H
Y
GGAA
GP
V
I
F
G
V
GY
NDIK
SW
W
LV
GA
VLT
I
L
T
FLV
HI
T
L
G
VW
WW
N
ML
I
GWN
fig|753642.3.peg.899
Escherichia coli NC101 (13-475/477)
LA
I
PC
II
G
F
M
P
A
PAGL
SEL
AW
V
L
F
GIY
L
A
A
IVGL
VIK
P
F
P
EP
VV
LL
IAV
A
-
AS
M
-
-
--
---
----
VV
V
G
N
L
SGG
E
FK
T
T
A
V
LSG
Y
SS
G
T
T
WLVF
S
AF
T
L
SA
AFV
T
TGLG
K
RIA
Y
L
L
IG
K
I
G
S
T
TL
G
LGY
V
T
VF
L
DLVLAP
A
TPSNTAR
A
GGIV
L
PII
N
SVAVA
LG
S
E
P
EK
S
P
R
-
R
V
G
H
YLM
MS
IY
M
V
T
KT
TS
Y
MF
F
TAMA
G
N
I
L
A
L
KM
I
ND
I
L
H
L
--
QISWG
G
W
A
L
AA
GL
P
GII
M
LL
V
T
P
LV
I
Y
TM
YPPEIK
KV
D
N
-
K
T
I
A
KA
G
L
AE
L
GP
M
KI
REK
M
LLG
V
F
VLAL
L
G
WIF
S
KSL
-
GV
D
E
S
T
V
A
IV
V
M
A
T
MLL
--
L
G
IV
T
W
E
D
V
V
K
NK
G
G
WNTL
I
W
YG
G
I
I
G
L
S
S
L
L
S
KV
K
F
F
E
W
L
A
EVFKN
N
L
A
F
D
GH
GN
--
V
-
AFF
V
I
I
F
LSI
IV
RYFFAS
G
SAY
I
V
AMLPV
FA
M
L
A
NVS
-
---
G
A
PL
MLT
A
L
A
L
LF
S
NS
Y
GG
M
V
T
H
Y
GGAA
GP
V
I
F
G
V
GY
NDIK
SW
W
LV
GA
VLT
I
L
T
FLV
HI
T
L
G
VW
WW
N
ML
I
GWN
fig|685038.3.peg.693
Escherichia coli O83:H1 str. NRG 857C (13-475/477)
LA
I
PC
II
G
F
M
P
A
PAGL
SEL
AW
V
L
F
GIY
L
A
A
IVGL
VIK
P
F
P
EP
VV
LL
IAV
A
-
AS
M
-
-
--
---
----
VV
V
G
N
L
SGG
E
FK
T
T
A
V
LSG
Y
SS
G
T
T
WLVF
S
AF
T
L
SA
AFV
T
TGLG
K
RIA
Y
L
L
IG
K
I
G
S
T
TL
G
LGY
V
T
VF
L
DLVLAP
A
TPSNTAR
A
GGIV
L
PII
N
SVAVA
LG
S
E
P
EK
S
P
R
-
R
V
G
H
YLM
MS
IY
M
V
T
KT
TS
Y
MF
F
TAMA
G
N
I
L
A
L
KM
I
ND
I
L
H
L
--
QISWG
G
W
A
L
AA
GL
P
GII
M
LL
V
T
P
LV
I
Y
TM
YPPEIK
KV
D
N
-
K
T
I
A
KA
G
L
AE
L
GP
M
KI
REK
M
LLG
V
F
VLAL
L
G
WIF
S
KSL
-
GV
D
E
S
T
V
A
IV
V
M
A
T
MLL
--
L
G
IV
T
W
E
D
V
V
K
NK
G
G
WNTL
I
W
YG
G
I
I
G
L
S
S
L
L
S
KV
K
F
F
E
W
L
A
EVFKN
N
L
A
F
D
GH
GN
--
V
-
AFF
V
I
I
F
LSI
IV
RYFFAS
G
SAY
I
V
AMLPV
FA
M
L
A
NVS
-
---
G
A
PL
MLT
A
L
A
L
LF
S
NS
Y
GG
M
V
T
H
Y
GGAA
GP
V
I
F
G
V
GY
NDIK
SW
W
LV
GA
VLT
I
L
T
FLV
HI
T
L
G
VW
WW
N
ML
I
GWN
fig|431946.3.peg.729
Escherichia coli SE15 (13-475/477)
LA
I
PC
II
G
F
M
P
A
PAGL
SEL
AW
V
L
F
GIY
L
A
A
IVGL
VIK
P
F
P
EP
VV
LL
IAV
A
-
AS
M
-
-
--
---
----
VV
V
G
N
L
SGG
E
FK
T
T
A
V
LSG
Y
SS
G
T
T
WLVF
S
AF
T
L
SA
AFV
T
TGLG
K
RIA
Y
L
L
IG
K
I
G
S
T
TL
G
LGY
V
T
VF
L
DLVLAP
A
TPSNTAR
A
GGIV
L
PII
N
SVAVA
LG
S
E
P
EK
S
P
R
-
R
V
G
H
YLM
MS
IY
M
V
T
KT
TS
Y
MF
F
TAMA
G
N
I
L
A
L
KM
I
ND
I
L
H
L
--
QISWG
G
W
A
L
AA
GL
P
GII
M
LL
V
T
P
LV
I
Y
TM
YPPEIK
KV
D
N
-
K
T
I
A
KA
G
L
AE
L
GP
M
KI
REK
M
LLG
V
F
VLAL
L
G
WIF
S
KSL
-
GV
D
E
S
T
V
A
IV
V
M
A
T
MLL
--
L
G
IV
T
W
E
D
V
V
K
NK
G
G
WNTL
I
W
YG
G
I
I
G
L
S
S
L
L
S
KV
K
F
F
E
W
L
A
EVFKN
N
L
A
F
D
GH
GN
--
V
-
AFF
V
I
I
F
LSI
IV
RYFFAS
G
SAY
I
V
AMLPV
FA
M
L
A
NVS
-
---
G
A
PL
MLT
A
L
A
L
LF
S
NS
Y
GG
M
V
T
H
Y
GGAA
GP
V
I
F
G
V
GY
NDIK
SW
W
LV
GA
VLT
I
L
T
FLV
HI
T
L
G
VW
WW
N
ML
I
GWN
fig|656440.3.peg.619
Escherichia coli TA206 (13-475/477)
LA
I
PC
II
G
F
M
P
A
PAGL
SEL
AW
V
L
F
GIY
L
A
A
IVGL
VIK
P
F
P
EP
VV
LL
IAV
A
-
AS
M
-
-
--
---
----
VV
V
G
N
L
SGG
E
FK
T
T
A
V
LSG
Y
SS
G
T
T
WLVF
S
AF
T
L
SA
AFV
T
TGLG
K
RIA
Y
L
L
IG
K
I
G
S
T
TL
G
LGY
V
T
VF
L
DLVLAP
A
TPSNTAR
A
GGIV
L
PII
N
SVAVA
LG
S
E
P
EK
S
P
R
-
R
V
G
H
YLM
MS
IY
M
V
T
KT
TS
Y
MF
F
TAMA
G
N
I
L
A
L
KM
I
ND
I
L
H
L
--
QISWG
G
W
A
L
AA
GL
P
GII
M
LL
V
T
P
LV
I
Y
TM
YPPEIK
KV
D
N
-
K
T
I
A
KA
G
L
AE
L
GP
M
KI
REK
M
LLG
V
F
VLAL
L
G
WIF
S
KSL
-
GV
D
E
S
T
V
A
IV
V
M
A
T
MLL
--
L
G
IV
T
W
E
D
V
V
K
NK
G
G
WNTL
I
W
YG
G
I
I
G
L
S
S
L
L
S
KV
K
F
F
E
W
L
A
EVFKN
N
L
A
F
D
GH
GN
--
V
-
AFF
V
I
I
F
LSI
IV
RYFFAS
G
SAY
I
V
AMLPV
FA
M
L
A
NVS
-
---
G
A
PL
MLT
A
L
A
L
LF
S
NS
Y
GG
M
V
T
H
Y
GGAA
GP
V
I
F
G
V
GY
NDIK
SW
W
LV
GA
VLT
I
L
T
FLV
HI
T
L
G
VW
WW
N
ML
I
GWN
fig|869729.3.peg.2945
Escherichia coli UM146 (13-475/477)
LA
I
PC
II
G
F
M
P
A
PAGL
SEL
AW
V
L
F
GIY
L
A
A
IVGL
VIK
P
F
P
EP
VV
LL
IAV
A
-
AS
M
-
-
--
---
----
VV
V
G
N
L
SGG
E
FK
T
T
A
V
LSG
Y
SS
G
T
T
WLVF
S
AF
T
L
SA
AFV
T
TGLG
K
RIA
Y
L
L
IG
K
I
G
S
T
TL
G
LGY
V
T
VF
L
DLVLAP
A
TPSNTAR
A
GGIV
L
PII
N
SVAVA
LG
S
E
P
EK
S
P
R
-
R
V
G
H
YLM
MS
IY
M
V
T
KT
TS
Y
MF
F
TAMA
G
N
I
L
A
L
KM
I
ND
I
L
H
L
--
QISWG
G
W
A
L
AA
GL
P
GII
M
LL
V
T
P
LV
I
Y
TM
YPPEIK
KV
D
N
-
K
T
I
A
KA
G
L
AE
L
GP
M
KI
REK
M
LLG
V
F
VLAL
L
G
WIF
S
KSL
-
GV
D
E
S
T
V
A
IV
V
M
A
T
MLL
--
L
G
IV
T
W
E
D
V
V
K
NK
G
G
WNTL
I
W
YG
G
I
I
G
L
S
S
L
L
S
KV
K
F
F
E
W
L
A
EVFKN
N
L
A
F
D
GH
GN
--
V
-
AFF
V
I
I
F
LSI
IV
RYFFAS
G
SAY
I
V
AMLPV
FA
M
L
A
NVS
-
---
G
A
PL
MLT
A
L
A
L
LF
S
NS
Y
GG
M
V
T
H
Y
GGAA
GP
V
I
F
G
V
GY
NDIK
SW
W
LV
GA
VLT
I
L
T
FLV
HI
T
L
G
VW
WW
N
ML
I
GWN
fig|364106.7.peg.856
Escherichia coli UTI89 (13-475/477)
LA
I
PC
II
G
F
M
P
A
PAGL
SEL
AW
V
L
F
GIY
L
A
A
IVGL
VIK
P
F
P
EP
VV
LL
IAV
A
-
AS
M
-
-
--
---
----
VV
V
G
N
L
SGG
E
FK
T
T
A
V
LSG
Y
SS
G
T
T
WLVF
S
AF
T
L
SA
AFV
T
TGLG
K
RIA
Y
L
L
IG
K
I
G
S
T
TL
G
LGY
V
T
VF
L
DLVLAP
A
TPSNTAR
A
GGIV
L
PII
N
SVAVA
LG
S
E
P
EK
S
P
R
-
R
V
G
H
YLM
MS
IY
M
V
T
KT
TS
Y
MF
F
TAMA
G
N
I
L
A
L
KM
I
ND
I
L
H
L
--
QISWG
G
W
A
L
AA
GL
P
GII
M
LL
V
T
P
LV
I
Y
TM
YPPEIK
KV
D
N
-
K
T
I
A
KA
G
L
AE
L
GP
M
KI
REK
M
LLG
V
F
VLAL
L
G
WIF
S
KSL
-
GV
D
E
S
T
V
A
IV
V
M
A
T
MLL
--
L
G
IV
T
W
E
D
V
V
K
NK
G
G
WNTL
I
W
YG
G
I
I
G
L
S
S
L
L
S
KV
K
F
F
E
W
L
A
EVFKN
N
L
A
F
D
GH
GN
--
V
-
AFF
V
I
I
F
LSI
IV
RYFFAS
G
SAY
I
V
AMLPV
FA
M
L
A
NVS
-
---
G
A
PL
MLT
A
L
A
L
LF
S
NS
Y
GG
M
V
T
H
Y
GGAA
GP
V
I
F
G
V
GY
NDIK
SW
W
LV
GA
VLT
I
L
T
FLV
HI
T
L
G
VW
WW
N
ML
I
GWN
fig|364106.8.peg.855
Escherichia coli UTI89 (13-475/477)
LA
I
PC
II
G
F
M
P
A
PAGL
SEL
AW
V
L
F
GIY
L
A
A
IVGL
VIK
P
F
P
EP
VV
LL
IAV
A
-
AS
M
-
-
--
---
----
VV
V
G
N
L
SGG
E
FK
T
T
A
V
LSG
Y
SS
G
T
T
WLVF
S
AF
T
L
SA
AFV
T
TGLG
K
RIA
Y
L
L
IG
K
I
G
S
T
TL
G
LGY
V
T
VF
L
DLVLAP
A
TPSNTAR
A
GGIV
L
PII
N
SVAVA
LG
S
E
P
EK
S
P
R
-
R
V
G
H
YLM
MS
IY
M
V
T
KT
TS
Y
MF
F
TAMA
G
N
I
L
A
L
KM
I
ND
I
L
H
L
--
QISWG
G
W
A
L
AA
GL
P
GII
M
LL
V
T
P
LV
I
Y
TM
YPPEIK
KV
D
N
-
K
T
I
A
KA
G
L
AE
L
GP
M
KI
REK
M
LLG
V
F
VLAL
L
G
WIF
S
KSL
-
GV
D
E
S
T
V
A
IV
V
M
A
T
MLL
--
L
G
IV
T
W
E
D
V
V
K
NK
G
G
WNTL
I
W
YG
G
I
I
G
L
S
S
L
L
S
KV
K
F
F
E
W
L
A
EVFKN
N
L
A
F
D
GH
GN
--
V
-
AFF
V
I
I
F
LSI
IV
RYFFAS
G
SAY
I
V
AMLPV
FA
M
L
A
NVS
-
---
G
A
PL
MLT
A
L
A
L
LF
S
NS
Y
GG
M
V
T
H
Y
GGAA
GP
V
I
F
G
V
GY
NDIK
SW
W
LV
GA
VLT
I
L
T
FLV
HI
T
L
G
VW
WW
N
ML
I
GWN
fig|562.376.peg.4838
Escherichia coli WV_060327 (13-475/477)
LA
I
PC
II
G
F
M
P
A
PAGL
SEL
AW
V
L
F
GIY
L
A
A
IVGL
VIK
P
F
P
EP
VV
LL
IAV
A
-
AS
M
-
-
--
---
----
VV
V
G
N
L
SGG
E
FK
T
T
A
V
LSG
Y
SS
G
T
T
WLVF
S
AF
T
L
SA
AFV
T
TGLG
K
RIA
Y
L
L
IG
K
I
G
S
T
TL
G
LGY
V
T
VF
L
DLVLAP
A
TPSNTAR
A
GGIV
L
PII
N
SVAVA
LG
S
E
P
EK
S
P
R
-
R
V
G
H
YLM
MS
IY
M
V
T
KT
TS
Y
MF
F
TAMA
G
N
I
L
A
L
KM
I
ND
I
L
H
L
--
QISWG
G
W
A
L
AA
GL
P
GII
M
LL
V
T
P
LV
I
Y
TM
YPPEIK
KV
D
N
-
K
T
I
A
KA
G
L
AE
L
GP
M
KI
REK
M
LLG
V
F
VLAL
L
G
WIF
S
KSL
-
GV
D
E
S
T
V
A
IV
V
M
A
T
MLL
--
L
G
IV
T
W
E
D
V
V
K
NK
G
G
WNTL
I
W
YG
G
I
I
G
L
S
S
L
L
S
KV
K
F
F
E
W
L
A
EVFKN
N
L
A
F
D
GH
GN
--
V
-
AFF
V
I
I
F
LSI
IV
RYFFAS
G
SAY
I
V
AMLPV
FA
M
L
A
NVS
-
---
G
A
PL
MLT
A
L
A
L
LF
S
NS
Y
GG
M
V
T
H
Y
GGAA
GP
V
I
F
G
V
GY
NDIK
SW
W
LV
GA
VLT
I
L
T
FLV
HI
T
L
G
VW
WW
N
ML
I
GWN
fig|439855.10.peg.948
Escherichia coli SMS-3-5 (1-454/456)
M
P
A
PAGL
SEL
AW
V
L
F
GIY
L
A
A
IVGL
VIK
P
F
P
EP
VV
LL
IAV
A
-
AS
M
-
-
--
---
----
VV
V
G
N
L
SGG
E
FK
T
T
A
V
LSG
Y
SS
G
T
T
WLVF
S
AF
T
L
SA
AFV
T
TGLG
K
RIA
Y
L
L
IG
K
I
G
S
T
TL
G
LGY
V
T
VF
L
DLVLAP
A
TPSNTAR
A
GGIV
L
PII
N
SVAVA
LG
S
E
P
EK
S
P
R
-
R
V
G
H
YLM
MS
IY
M
V
T
KT
TS
Y
MF
F
TAMA
G
N
I
L
A
L
KM
I
ND
I
L
H
L
--
QISWG
G
W
A
L
AA
GL
P
GII
M
LL
V
T
P
LV
I
Y
TM
YPPEIK
KV
D
N
-
K
T
I
A
KA
G
L
AE
L
GP
M
KI
REK
M
LLG
V
F
VLAL
L
G
WIF
S
KSL
-
GV
D
E
S
T
V
A
IV
V
M
A
T
MLL
--
L
G
IV
T
W
E
D
V
V
K
NK
G
G
WNTL
I
W
YG
G
I
I
G
L
S
S
L
L
S
KV
K
F
F
E
W
L
A
EVFKN
N
L
A
F
D
GH
GN
--
V
-
AFF
V
I
I
F
LSI
IV
RYFFAS
G
SAY
I
V
AMLPV
FA
M
L
A
NVS
-
---
G
A
PL
MLT
A
L
A
L
LF
S
NS
Y
GG
M
V
T
H
Y
GGAA
GP
V
I
F
G
V
GY
NDIK
SW
W
LV
GA
VLT
I
L
T
FLV
HI
T
L
G
VW
WW
N
ML
I
GWN
fig|656417.3.peg.1821
Escherichia coli M605 (28-492/492)
L
AC
M
S
Y
F
FL
Q
P
E
GL
NTF
AW
R
TVI
I
F
V
A
T
IV
S
I
I
CRV
L
P
IG
A
L
GI
L
A
I
T
V
YA
L
-
-
--
---
----
TF
S
G
G
A
RLA
S
KS
I
T
D
A
LS
AM
N
N
S
L
I
WL
I
V
T
AF
M
I
AR
G
F
I
K
TGLG
Q
RIAL
I
LVK
I
L
G
K
RTL
G
L
A
Y
G
L
AL
A
DL
L
LAP
A
M
PSNTAR
C
GG
V
I
Y
P
V
A
D
S
L
SRS
FD
S
F
P
DN
D
S
R
R
KM
G
T
F
L
V
CC
IG
T
V
N
DV
TS
T
L
F
L
T
G
FTA
NLL
A
V
KL
A
A-
L
Q
G
V
--
S
L
T
W
I
N
WF
T
AM
L
M
P
C
L
L
SF
I
I
T
P
L
A
V
Y
L
FVS
PEIK
TT
P
S
A
P
LA
A
TE
Q
L
KT
MG
K
M
TI
RE
W
G
M
V
G
T
M
L
L
L
L
V
LWI
V
G
AQV
-
H
V
D
Q
T
T
T
A
FI
G
L
S
VL
LL
--
S
G
V
L
T
W
E
D
V
K
N
E
K
D
AW
D
TL
I
W
F
S
A
L
L
M
LAS
Q
L
S
KL
GF
T
G
WF
G
HLIAS
D
I
G
L
M
VR
DI
HW
V
Y
ILI
I
L
N
I
IY
C
YL
H
YFFAS
G
N
A
IV
A
A
L
YS
V
FL
G
V
G
CSL
-
---
G
V
P
A
LPM
A
L
M
L
AC
CTN
I
SC
S
LT
Q
Y
TH
A
R
GPI
L
F
G
A
GY
VPTG
L
W
WR
T
G
F
I
MS
VI
N
LF
I
FF
S
T
G
LI
WW
K
I
L
E
L
Y
fig|340185.4.peg.4516
Escherichia coli E22 (6-461/464)
LL
PI
I
FF
PV
L
F
W
V
IP
H
P
E
G
V
SAQ
T
W
E
MV
GIY
L
A
M
L
C
GL
V
L
R
P
F
T
DA
I
I
ML
I
I
L
GF
AS
L
-
-
--
---
----
VV
-
-
-
-
---
-
-E
P
G
P
L
F
A
GF
G
S
P
M
V
W
F
I
I
S
AF
I
I
CK
AFV
I
TGLG
K
RIA
Y
L
L
LQR
Y
G
K
N
TL
T
LGY
L
M
MI
T
D
T
VLAP
A
T
G
SN
M
S
R
S
GGI
T
Y
PI
F
R
N
I
A
E
A
LG
S
K
P
DE
G
S
R
-
K
IG
A
YL
TI
L
MY
V
V
S
MG
TS
S
L
F
L
T
G
MA
T
N
S
I
T
V
SL
A
NE
I
M
S
V
--
N
L
E
W
M
V
W
LK
AA
V
V
P
AG
I
V
LL
A
A
PW
I
L
Y
K
LY
A
PE
L
K
TI
T
N
V
N
E
I
A
NK
G
L
QE
L
GP
V
KR
E
EK
L
L
I
VF
F
VL
G
I
I
G
W
M
T
G
SIT
-
G
I
E
FI
P
VG
LA
F
L
A
C
L
LL
--
F
G
V
L
S
W
N
D
V
V
S
E
K
S
AW
Q
T
F
V
W
YG
A
FY
G
C
A
VA
L
S
KG
GF
Y
V
Y
L
V
DVIKN
Y
L
D
L
S
QL
SE
--
IS
ALG
VL
V
F
I
S
L
AV
RYFF
V
S
N
SA
F
V
V
S
FY
PV
LF
T
L
G
MTT
-
---
Q
A
HP
MYI
A
L
S
L
AF
S
A
G
Y
G
A
L
LT
H
Y
G
N
G
A
G
V
FT
F
S
S
GY
VPQK
T
F
W
L
LG
T
I
MV
LV
N
V
LV
YF
L
I
G
IP
Y
W
K
M
fig|340185.3.peg.4282
Escherichia coli E22 (16-471/474)
LL
PI
I
FF
PV
L
F
W
V
IP
H
P
E
G
V
SAQ
T
W
E
MV
GIY
L
A
M
L
C
GL
V
L
R
P
F
T
DA
I
I
ML
I
I
L
GF
AS
L
-
-
--
---
----
VV
-
-
-
-
---
-
-E
P
G
P
L
F
A
GF
G
S
P
M
V
W
F
I
I
S
AF
I
I
CK
AFV
I
TGLG
K
RIA
Y
L
L
LQR
Y
G
K
N
TL
T
LGY
L
M
MI
T
D
T
VLAP
A
T
G
SN
M
S
R
S
GGI
T
Y
PI
F
R
N
I
A
E
A
LG
S
K
P
DE
G
S
R
-
K
IG
A
YL
TI
L
MY
V
V
S
MG
TS
S
L
F
L
T
G
MA
T
N
S
I
T
V
SL
A
NE
I
M
S
V
--
N
L
E
W
M
V
W
LK
AA
V
V
P
AG
I
V
LL
A
A
PW
I
L
Y
K
LY
A
PE
L
K
TI
T
N
V
N
E
I
A
NK
G
L
QE
L
GP
V
KR
E
EK
L
L
I
VF
F
VL
G
I
I
G
W
M
T
G
SIT
-
G
I
E
FI
P
VG
LA
F
L
A
C
L
LL
--
F
G
V
L
S
W
N
D
V
V
S
E
K
S
AW
Q
T
F
V
W
YG
A
FY
G
C
A
VA
L
S
KG
GF
Y
V
Y
L
V
DVIKN
Y
L
D
L
S
QL
SE
--
IS
ALG
VL
V
F
I
S
L
AV
RYFF
V
S
N
SA
F
V
V
S
FY
PV
LF
T
L
G
MTT
-
---
Q
A
HP
MYI
A
L
S
L
AF
S
A
G
Y
G
A
L
LT
H
Y
G
N
G
A
G
V
FT
F
S
S
GY
VPQK
T
F
W
L
LG
T
I
MV
LV
N
V
LV
YF
L
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fig|405955.9.peg.3831
Escherichia coli APEC O1 (31-500/501)
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fig|199310.1.peg.4933
Escherichia coli CFT073 (31-500/501)
II
T
L
L
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fig|216593.1.peg.3964
Escherichia coli E2348/69 (31-500/501)
II
T
L
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fig|670897.3.peg.1356
Escherichia coli 2362-75 (29-498/499)
II
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L
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fig|525281.3.peg.1831
Escherichia coli 83972 (29-498/499)
II
T
L
L
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A
L
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fig|655817.3.peg.4783
Escherichia coli ABU 83972 (29-498/499)
II
T
L
L
P
L
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T
L
PVA
GQ
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MI
A
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L
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M
T
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N
S
A
L
A
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A
A
A
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F
I
AA
A
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L
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fig|405955.13.peg.4540
Escherichia coli APEC O1 (29-498/499)
II
T
L
L
P
L
G
D
T
L
PVA
GQ
N
MI
A
I
L
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A
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M
D
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--
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A
I
V
I
SA
L
I
I
FM
V
G
F
APDM
NH
P
D
T
I
LGT
A
KA
L
K
M
T
LSGFS
N
S
A
L
A
LV
A
A
A
M
F
I
AA
A
MT
I
TGL
D
K
RIAL
F
T
M
S
K
I
G
A
S
S
R
S
I
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A
I
V
V
T
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L
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A
L
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L
I
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L
L
L
L
F
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T
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V
T
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L
A
I
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PG
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G
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I
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L
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S
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L
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G
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--
LA
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L
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I
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fig|199310.4.peg.4729
Escherichia coli CFT073 (29-498/499)
II
T
L
L
P
L
G
D
T
L
PVA
GQ
N
MI
A
I
L
V
F
A
I
I
VW
I
S
E
A
M
D
YT
A
S
--
-
A
I
V
I
SA
L
I
I
FM
V
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F
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NH
P
D
T
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A
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L
K
M
T
LSGFS
N
S
A
L
A
LV
A
A
A
M
F
I
AA
A
MT
I
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D
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F
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K
I
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A
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V
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V
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M
M
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-
-
R
L
A
A
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M
M
I
V
IA
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A
T
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N
V
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T
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A
A
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S
I
GF
I
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T
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A
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V
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L
D
W
L
L
AG
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L
T
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V
I
L
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L
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L
L
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G
G
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L
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L
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T
TG
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L
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L
L
L
L
F
W
ST
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ID
T
T
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V
T
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L
A
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I
G
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V
-
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V
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L
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G
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G
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L
G
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T
L
L
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W
M
A
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GF
G
L
D
G
L
PS
--
LA
IFA
I
L
A
A
FL
I
II
H
LG
FAS
A
T
A
L
T
A
A
L
LP
I
LI
S
L
L
SSL
P
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G
V
NP
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T
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L
L
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G
F
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L
-
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G
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L
L
LL
L
FA
AT
WW
K
I
L
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L
fig|714962.3.peg.4578
Escherichia coli IHE3034 (29-498/499)
II
T
L
L
P
L
G
D
T
L
PVA
GQ
N
MI
A
I
L
V
F
A
I
I
VW
I
S
E
A
M
D
YT
A
S
--
-
A
I
V
I
SA
L
I
I
FM
V
G
F
APDM
NH
P
D
T
I
LGT
A
KA
L
K
M
T
LSGFS
N
S
A
L
A
LV
A
A
A
M
F
I
AA
A
MT
I
TGL
D
K
RIAL
F
T
M
S
K
I
G
A
S
S
R
S
I
IIG
A
I
V
V
T
I
VL
S
L
V
V
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A
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T
A
C
V
V
-
PI
M
M
G
V
IA
A
FK
V
D
K
H
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-
-
R
L
A
A
S
M
M
I
V
IA
Q
A
T
SI
W
N
V
GI
Q
T
S
A
A
Q
NLL
S
I
GF
I
NK
T
F
G
A
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V
SW
L
D
W
L
L
AG
A
P
W
S
L
T
M
S
V
I
L
Y
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L
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L
L
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T
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AV
E
G
G
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KK
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L
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L
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T
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K
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R
L
I
G
I
S
L
L
L
L
L
F
W
ST
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ID
T
T
S
V
T
LA
G
L
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I
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G
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M
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K
R
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TL
L
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G
I
G
I
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L
G
S
T
L
L
DT
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S
W
M
A
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GF
G
L
D
G
L
PS
--
LA
IFA
I
L
A
A
FL
I
II
H
LG
FAS
A
T
A
L
T
A
A
L
LP
I
LI
S
L
L
SSL
P
PEL
G
V
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T
I
L
L
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S
V
S
F
G
F
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L
-
P
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CM
G
T
DT
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LY
LT
VI
G
Y
L
L
LL
L
FA
AT
WW
K
I
L
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L
fig|656417.3.peg.5125
Escherichia coli M605 (29-498/499)
II
T
L
L
P
L
G
D
T
L
PVA
GQ
N
MI
A
I
L
V
F
A
I
I
VW
I
S
E
A
M
D
YT
A
S
--
-
A
I
V
I
SA
L
I
I
FM
V
G
F
APDM
NH
P
D
T
I
LGT
A
KA
L
K
M
T
LSGFS
N
S
A
L
A
LV
A
A
A
M
F
I
AA
A
MT
I
TGL
D
K
RIAL
F
T
M
S
K
I
G
A
S
S
R
S
I
IIG
A
I
V
V
T
I
VL
S
L
V
V
PS
A
TAR
T
A
C
V
V
-
PI
M
M
G
V
IA
A
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V
D
K
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-
-
R
L
A
A
S
M
M
I
V
IA
Q
A
T
SI
W
N
V
GI
Q
T
S
A
A
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S
I
GF
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L
D
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L
L
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A
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L
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V
I
L
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L
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L
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E
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G
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KK
A
L
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L
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T
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R
L
I
G
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S
L
L
L
L
L
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W
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ID
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T
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V
T
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G
L
A
I
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K
R
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L
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G
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G
I
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L
G
S
T
L
L
DT
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S
W
M
A
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GF
G
L
D
G
L
PS
--
LA
IFA
I
L
A
A
FL
I
II
H
LG
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A
T
A
L
T
A
A
L
LP
I
LI
S
L
L
SSL
P
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G
V
NP
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T
I
L
L
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V
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L
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G
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LT
VI
G
Y
L
L
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L
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AT
WW
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L
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L
fig|749546.3.peg.1023
Escherichia coli MS 185-1 (29-498/499)
II
T
L
L
P
L
G
D
T
L
PVA
GQ
N
MI
A
I
L
V
F
A
I
I
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I
S
E
A
M
D
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A
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--
-
A
I
V
I
SA
L
I
I
FM
V
G
F
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NH
P
D
T
I
LGT
A
KA
L
K
M
T
LSGFS
N
S
A
L
A
LV
A
A
A
M
F
I
AA
A
MT
I
TGL
D
K
RIAL
F
T
M
S
K
I
G
A
S
S
R
S
I
IIG
A
I
V
V
T
I
VL
S
L
V
V
PS
A
TAR
T
A
C
V
V
-
PI
M
M
G
V
IA
A
FK
V
D
K
H
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-
-
R
L
A
A
S
M
M
I
V
IA
Q
A
T
SI
W
N
V
GI
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T
S
A
A
Q
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S
I
GF
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T
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A
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V
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L
D
W
L
L
AG
A
P
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S
L
T
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S
V
I
L
Y
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L
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L
L
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T
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E
G
G
S
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KK
A
L
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L
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T
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R
L
I
G
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S
L
L
L
L
L
F
W
ST
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ID
T
T
S
V
T
LA
G
L
A
I
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PG
I
G
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M
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WK
E
V
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K
R
V
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W
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TL
L
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G
I
G
I
S
L
G
S
T
L
L
DT
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S
W
M
A
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GF
G
L
D
G
L
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--
LA
IFA
I
L
A
A
FL
I
II
H
LG
FAS
A
T
A
L
T
A
A
L
LP
I
LI
S
L
L
SSL
P
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G
V
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T
I
L
L
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L
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G
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G
Y
L
L
LL
L
FA
AT
WW
K
I
L
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L
fig|749528.3.peg.4441
Escherichia coli MS 45-1 (29-498/499)
II
T
L
L
P
L
G
D
T
L
PVA
GQ
N
MI
A
I
L
V
F
A
I
I
VW
I
S
E
A
M
D
YT
A
S
--
-
A
I
V
I
SA
L
I
I
FM
V
G
F
APDM
NH
P
D
T
I
LGT
A
KA
L
K
M
T
LSGFS
N
S
A
L
A
LV
A
A
A
M
F
I
AA
A
MT
I
TGL
D
K
RIAL
F
T
M
S
K
I
G
A
S
S
R
S
I
IIG
A
I
V
V
T
I
VL
S
L
V
V
PS
A
TAR
T
A
C
V
V
-
PI
M
M
G
V
IA
A
FK
V
D
K
H
S--
-
-
R
L
A
A
S
M
M
I
V
IA
Q
A
T
SI
W
N
V
GI
Q
T
S
A
A
Q
NLL
S
I
GF
I
NK
T
F
G
A
GHS
V
SW
L
D
W
L
L
AG
A
P
W
S
L
T
M
S
V
I
L
Y
F
L
A
RK
L
L
PPE
T
E
AV
E
G
G
S
EAI
KK
A
L
AE
L
GP
T
TG
K
EK
R
L
I
G
I
S
L
L
L
L
L
F
W
ST
G
GKL
HS
ID
T
T
S
V
T
LA
G
L
A
I
MLL
PG
I
G
V
M
S
WK
E
V
-
E
K
R
V
Q
W
G
TL
L
MF
G
I
G
I
S
L
G
S
T
L
L
DT
QAA
S
W
M
A
NYVVK
GF
G
L
D
G
L
PS
--
LA
IFA
I
L
A
A
FL
I
II
H
LG
FAS
A
T
A
L
T
A
A
L
LP
I
LI
S
L
L
SSL
P
PEL
G
V
NP
VGM
T
I
L
L
AF
S
V
S
F
G
F
I
L
-
P
INAPQNM
V
CM
G
T
DT
FTPR
Q
F
T
R
V
G
LY
LT
VI
G
Y
L
L
LL
L
FA
AT
WW
K
I
L
G
L
fig|753642.3.peg.4103
Escherichia coli NC101 (29-498/499)
II
T
L
L
P
L
G
D
T
L
PVA
GQ
N
MI
A
I
L
V
F
A
I
I
VW
I
S
E
A
M
D
YT
A
S
--
-
A
I
V
I
SA
L
I
I
FM
V
G
F
APDM
NH
P
D
T
I
LGT
A
KA
L
K
M
T
LSGFS
N
S
A
L
A
LV
A
A
A
M
F
I
AA
A
MT
I
TGL
D
K
RIAL
F
T
M
S
K
I
G
A
S
S
R
S
I
IIG
A
I
V
V
T
I
VL
S
L
V
V
PS
A
TAR
T
A
C
V
V
-
PI
M
M
G
V
IA
A
FK
V
D
K
H
S--
-
-
R
L
A
A
S
M
M
I
V
IA
Q
A
T
SI
W
N
V
GI
Q
T
S
A
A
Q
NLL
S
I
GF
I
NK
T
F
G
A
GHS
V
SW
L
D
W
L
L
AG
A
P
W
S
L
T
M
S
V
I
L
Y
F
L
A
RK
L
L
PPE
T
E
AV
E
G
G
S
EAI
KK
A
L
AE
L
GP
T
TG
K
EK
R
L
I
G
I
S
L
L
L
L
L
F
W
ST
G
GKL
HS
ID
T
T
S
V
T
LA
G
L
A
I
MLL
PG
I
G
V
M
S
WK
E
V
-
E
K
R
V
Q
W
G
TL
L
MF
G
I
G
I
S
L
G
S
T
L
L
DT
QAA
S
W
M
A
NYVVK
GF
G
L
D
G
L
PS
--
LA
IFA
I
L
A
A
FL
I
II
H
LG
FAS
A
T
A
L
T
A
A
L
LP
I
LI
S
L
L
SSL
P
PEL
G
V
NP
VGM
T
I
L
L
AF
S
V
S
F
G
F
I
L
-
P
INAPQNM
V
CM
G
T
DT
FTPR
Q
F
T
R
V
G
LY
LT
VI
G
Y
L
L
LL
L
FA
AT
WW
K
I
L
G
L
fig|685038.3.peg.4139
Escherichia coli O83:H1 str. NRG 857C (29-498/499)
II
T
L
L
P
L
G
D
T
L
PVA
GQ
N
MI
A
I
L
V
F
A
I
I
VW
I
S
E
A
M
D
YT
A
S
--
-
A
I
V
I
SA
L
I
I
FM
V
G
F
APDM
NH
P
D
T
I
LGT
A
KA
L
K
M
T
LSGFS
N
S
A
L
A
LV
A
A
A
M
F
I
AA
A
MT
I
TGL
D
K
RIAL
F
T
M
S
K
I
G
A
S
S
R
S
I
IIG
A
I
V
V
T
I
VL
S
L
V
V
PS
A
TAR
T
A
C
V
V
-
PI
M
M
G
V
IA
A
FK
V
D
K
H
S--
-
-
R
L
A
A
S
M
M
I
V
IA
Q
A
T
SI
W
N
V
GI
Q
T
S
A
A
Q
NLL
S
I
GF
I
NK
T
F
G
A
GHS
V
SW
L
D
W
L
L
AG
A
P
W
S
L
T
M
S
V
I
L
Y
F
L
A
RK
L
L
PPE
T
E
AV
E
G
G
S
EAI
KK
A
L
AE
L
GP
T
TG
K
EK
R
L
I
G
I
S
L
L
L
L
L
F
W
ST
G
GKL
HS
ID
T
T
S
V
T
LA
G
L
A
I
MLL
PG
I
G
V
M
S
WK
E
V
-
E
K
R
V
Q
W
G
TL
L
MF
G
I
G
I
S
L
G
S
T
L
L
DT
QAA
S
W
M
A
NYVVK
GF
G
L
D
G
L
PS
--
LA
IFA
I
L
A
A
FL
I
II
H
LG
FAS
A
T
A
L
T
A
A
L
LP
I
LI
S
L
L
SSL
P
PEL
G
V
NP
VGM
T
I
L
L
AF
S
V
S
F
G
F
I
L
-
P
INAPQNM
V
CM
G
T
DT
FTPR
Q
F
T
R
V
G
LY
LT
VI
G
Y
L
L
LL
L
FA
AT
WW
K
I
L
G
L
fig|585035.6.peg.4438
Escherichia coli S88 (29-498/499)
II
T
L
L
P
L
G
D
T
L
PVA
GQ
N
MI
A
I
L
V
F
A
I
I
VW
I
S
E
A
M
D
YT
A
S
--
-
A
I
V
I
SA
L
I
I
FM
V
G
F
APDM
NH
P
D
T
I
LGT
A
KA
L
K
M
T
LSGFS
N
S
A
L
A
LV
A
A
A
M
F
I
AA
A
MT
I
TGL
D
K
RIAL
F
T
M
S
K
I
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--
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I
L
A
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L
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AT
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fig|431946.3.peg.4081
Escherichia coli SE15 (29-498/499)
II
T
L
L
P
L
G
D
T
L
PVA
GQ
N
MI
A
I
L
V
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A
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A
M
D
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--
-
A
I
V
I
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L
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V
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NH
P
D
T
I
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A
KA
L
K
M
T
LSGFS
N
S
A
L
A
LV
A
A
A
M
F
I
AA
A
MT
I
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D
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RIAL
F
T
M
S
K
I
G
A
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S
R
S
I
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V
T
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L
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T
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V
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M
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L
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M
I
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T
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A
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S
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G
L
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--
LA
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I
L
A
A
FL
I
II
H
LG
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A
T
A
L
T
A
A
L
LP
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LI
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L
L
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P
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T
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L
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G
Y
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L
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AT
WW
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L
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fig|656440.3.peg.4619
Escherichia coli TA206 (29-498/499)
II
T
L
L
P
L
G
D
T
L
PVA
GQ
N
MI
A
I
L
V
F
A
I
I
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S
E
A
M
D
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A
S
--
-
A
I
V
I
SA
L
I
I
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V
G
F
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NH
P
D
T
I
LGT
A
KA
L
K
M
T
LSGFS
N
S
A
L
A
LV
A
A
A
M
F
I
AA
A
MT
I
TGL
D
K
RIAL
F
T
M
S
K
I
G
A
S
S
R
S
I
IIG
A
I
V
V
T
I
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S
L
V
V
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A
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T
A
C
V
V
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M
M
G
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A
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-
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R
L
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M
I
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T
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--
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I
L
A
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I
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L
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AT
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fig|869729.3.peg.4389
Escherichia coli UM146 (29-498/499)
II
T
L
L
P
L
G
D
T
L
PVA
GQ
N
MI
A
I
L
V
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D
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--
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A
I
V
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SA
L
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V
G
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P
D
T
I
LGT
A
KA
L
K
M
T
LSGFS
N
S
A
L
A
LV
A
A
A
M
F
I
AA
A
MT
I
TGL
D
K
RIAL
F
T
M
S
K
I
G
A
S
S
R
S
I
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A
I
V
V
T
I
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L
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A
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T
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C
V
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M
M
G
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IA
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L
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L
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ID
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L
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G
L
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--
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I
L
A
A
FL
I
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A
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L
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AT
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fig|562.376.peg.1705
Escherichia coli WV_060327 (29-498/499)
II
T
L
L
P
L
G
D
T
L
PVA
GQ
N
MI
A
I
L
V
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M
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--
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I
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I
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L
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V
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P
D
T
I
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A
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L
K
M
T
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N
S
A
L
A
LV
A
A
A
M
F
I
AA
A
MT
I
TGL
D
K
RIAL
F
T
M
S
K
I
G
A
S
S
R
S
I
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A
I
V
V
T
I
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L
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A
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M
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L
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L
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L
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L
I
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L
L
L
L
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ID
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T
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L
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I
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L
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T
L
L
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S
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M
A
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GF
G
L
D
G
L
PS
--
LA
IFA
I
L
A
A
FL
I
II
H
LG
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A
T
A
L
T
A
A
L
LP
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L
L
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T
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L
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L
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L
L
LL
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FA
AT
WW
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L
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fig|574521.7.peg.4474
Escherichia coli O127:H6 str. E2348/69 (29-498/499)
II
T
L
L
P
L
G
D
T
L
PVA
GQ
N
MI
A
I
L
V
F
A
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S
E
A
M
D
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--
-
A
I
V
I
SA
L
I
I
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V
G
F
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NH
P
D
T
I
LGT
A
KA
L
K
M
T
LSGFS
N
S
A
L
A
LV
A
A
A
M
F
I
AA
A
MT
I
TGL
D
K
RIAL
F
T
M
S
K
I
G
A
S
S
R
S
I
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A
I
V
V
T
I
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L
V
V
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A
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T
A
C
V
V
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M
M
G
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M
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A
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S
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L
D
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L
L
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A
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L
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V
I
L
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L
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L
L
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E
G
G
S
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KK
A
L
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L
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T
TG
K
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R
L
I
G
I
S
L
L
L
L
L
F
W
ST
G
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ID
T
T
S
V
T
LA
G
L
A
I
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I
G
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M
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E
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-
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K
R
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Q
W
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TL
L
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G
I
G
I
S
L
G
S
T
L
L
DT
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S
W
M
A
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GF
G
L
D
G
L
PS
--
LA
IFA
I
L
A
A
FL
I
II
H
LG
FAS
A
T
A
L
T
A
A
L
LP
I
LI
S
L
L
SSL
P
PEL
G
V
NP
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T
I
L
L
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S
V
S
F
G
F
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L
-
P
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V
CM
G
T
DT
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Q
F
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LY
LT
VI
G
Y
L
L
LL
L
FA
AT
WW
K
I
L
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L
fig|364106.7.peg.4514
Escherichia coli UTI89 (29-498/499)
II
T
L
L
P
L
G
D
T
L
PVA
GQ
N
MI
A
I
L
V
F
A
I
I
VW
I
S
E
A
M
D
YT
A
S
--
-
A
I
V
I
SA
L
I
I
FM
V
G
F
APDM
NH
P
D
T
I
LGT
A
KA
L
K
M
T
LSGFS
N
S
A
L
A
LV
A
A
A
M
F
I
AA
A
MT
I
TGL
D
K
RIAL
F
T
M
S
K
I
G
A
S
S
R
S
I
IIG
A
I
V
V
T
I
VL
S
L
V
V
PS
A
TAR
T
A
C
V
V
-
PI
M
M
G
V
IA
A
FK
V
D
K
H
S--
-
-
R
L
A
A
S
M
M
I
V
IA
Q
A
T
SI
W
N
V
GI
Q
T
S
A
A
Q
NLL
S
I
GF
I
NK
T
F
G
A
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V
SW
L
D
W
L
L
AG
A
P
W
S
L
T
M
S
VL
L
Y
F
L
A
RK
L
L
PPE
T
E
AV
E
G
G
S
EAI
KK
A
L
AE
L
GP
T
TG
K
EK
R
L
I
G
I
S
L
L
L
L
L
F
W
ST
G
GKL
HS
ID
T
T
S
V
T
LA
G
L
A
I
MLL
PG
I
G
V
M
S
WK
E
V
-
E
K
R
V
Q
W
G
TL
L
MF
G
I
G
I
S
L
G
S
T
L
L
DT
QAA
S
W
M
A
NYVVK
GF
G
L
D
G
L
PS
--
LA
IFA
I
L
A
A
FL
I
II
H
LG
FAS
A
T
A
L
T
A
A
L
LP
I
LI
S
L
L
SSL
P
PEL
G
V
NP
VGM
T
I
L
L
AF
S
V
S
F
G
F
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L
-
P
INAPQNM
V
CM
G
T
DT
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Q
F
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V
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LY
LT
VI
G
Y
L
L
LL
L
FA
AT
WW
K
I
L
G
L
fig|364106.8.peg.4513
Escherichia coli UTI89 (29-498/499)
II
T
L
L
P
L
G
D
T
L
PVA
GQ
N
MI
A
I
L
V
F
A
I
I
VW
I
S
E
A
M
D
YT
A
S
--
-
A
I
V
I
SA
L
I
I
FM
V
G
F
APDM
NH
P
D
T
I
LGT
A
KA
L
K
M
T
LSGFS
N
S
A
L
A
LV
A
A
A
M
F
I
AA
A
MT
I
TGL
D
K
RIAL
F
T
M
S
K
I
G
A
S
S
R
S
I
IIG
A
I
V
V
T
I
VL
S
L
V
V
PS
A
TAR
T
A
C
V
V
-
PI
M
M
G
V
IA
A
FK
V
D
K
H
S--
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R
L
A
A
S
M
M
I
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fig|340197.3.peg.2063
Escherichia coli F11 (31-500/501)
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T
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fig|362663.8.peg.4312
Escherichia coli 536 (29-498/499)
II
T
L
L
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fig|362663.9.peg.4328
Escherichia coli 536 (29-498/499)
II
T
L
L
P
L
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D
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N
MI
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M
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A
L
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A
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I
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fig|585397.7.peg.4758
Escherichia coli ED1a (29-498/499)
II
T
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fig|585397.9.peg.4758
Escherichia coli ED1a (29-498/499)
II
T
L
L
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MI
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L
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I
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fig|340197.5.peg.2175
Escherichia coli F11 (29-498/499)
II
T
L
L
P
L
G
D
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L
PVA
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MI
A
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L
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I
AA
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fig|749550.3.peg.1450
Escherichia coli MS 200-1 (29-498/499)
II
T
L
L
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MI
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A
L
AE
L
GP
T
TG
K
EK
R
L
I
G
I
S
L
L
L
L
L
F
W
ST
G
GKL
HS
ID
T
T
S
V
T
LA
G
L
A
I
MLL
PG
I
G
V
M
S
WK
E
V
-
E
K
R
V
Q
W
G
TL
L
MF
G
I
G
I
S
L
G
S
T
L
L
DT
QAA
S
W
M
A
NYVVK
GF
G
L
D
G
L
PS
--
LA
IFA
I
L
A
A
FL
I
II
H
LG
FAS
A
T
A
L
T
A
A
L
LP
I
LI
S
L
L
SSL
P
PEL
G
V
NP
VGM
T
I
L
L
AF
S
V
S
F
G
F
I
L
-
P
INAPQNM
V
CM
G
T
DT
FTPR
Q
F
T
R
V
G
LY
LT
VI
G
Y
L
L
LL
L
FA
AT
WW
K
I
L
G
L
Consen1
Primary consensus
LlAPLav
ii
liP
PaGl
aW
yFavf
a
IVGlileP
P
vv
iavti
i
s
llf
la
p
f
a
l
w
lsGfSs
t
WLvF
AF
f
gye
tGLGrRIAl
LvkkmG
rTL
LGYa
vf
dlvLAP
TPSNtAR
gGiv
PiI
nlppl
S
Pndss
rriG
YlMwm
i
t
tS
mF
TamApNlL
l
i
i
h
--
qiSWg
WfL
lp
giillli
Pwl
YvlYpPeik
d
v
twA
eL
mGpl
REk
llGl
vlaL
lWiFg
--
idat
Vg
vvalMLl
--
L
iv
WkDiv
nk
aWNtl
wla
li
lasgLt
gFi
Wfa
hL
g
sp
----
vli
vfy
rYfFAS
sAyt
amlPv
a
a
p
---
g
Pl
cl
l
sig
gg
lTpYatgpgpiiyG
GY
dyWrlGAifgvi
flvll
vg
ww
ml
gWN
Consen2
Secondary consensus
m
vi
vm
f
d
m
t
l
giy
g
mvik
ai
vgi
-
m
-
---
vv
g
l
k
t
a
va
y
n
v
i
l
afv
s
k
y
igfi
t
v
mi
ei
s
a
ti
v
svava
ekpp
-
sv
i
ms
d
s
i
ga
g
i
a
g
tl
l
a
gl
svlmvi
lv
tm
k
vlt
e
-
ri
g
l
am
w
mi
v
lgs
g
v
s
gvne
a
amst
a
vi
vt
yn
g
vf
nyg
iv
ms
l
k
f
lg
f
gh
v
aiv
lsi
h
l
t
hi
tla
m
m
g
-
e
m
ai
v
ans
ms
v
h
ggaasvvyf
sw
lv
vlt
l
ismhi
t
il
iw
l
Consensus 1
(when a gap)
Conservative difference
Consensus 2
(when a gap)
Nonconservative diff.
Other character