fig|1040638.4.peg.5274
Escherichia coli O104:H4 str. LB226692
MNKKIHSL
A
LLVNL
G
IYGVA
--
-
Q
A
Q
EP
TD
TPVSH
DDT
I
VVTA
-
A
E
Q
N
L
-
Q
AP
GV
S
---
-------------
T
I
T
A
DEIR
K
N
P
V
A
R
DVS
E
II
R
T
MPGVN
L
---
--
TGNST
S
G
Q
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
K
P
VS
S
R
NSV
RQGW
RGE
RDT
RG
DTSWVPPEM
I
E
R
I
EVLRGP
A
AA
R
YG
N
G
A
A
GG
V
V
NIITK
KG
SGEWH
G
SW
D
A
Y
F
NA
PE
H
KEEGATK
R
TN
FSLTGP
L
-
GD
EFSF
RLYG
NLD
--
KT
Q
A
D
AWD
IN
Q
--
G
HQSAR
AGTYATTLP
AGR
EG
V
I
N
K
DINGV
VR
WDF
AP
LQ
S
LELEA
G
YSRQGN
L
-
Y
AGD
TQ
NTNS
D
---------------
AY
T
RS
--
KY
G
D
-
E
T
NRL
Y
RQ
NY
A
LTWN
GG
WD
N
G
V
T
T
S
NWVQY
EH
-----------
TR
N
SR
IP
E
-
----
G
LA
G
-----
G
TEGKFNEK
A
TQDFVDI
D
L
D
D
V
M
L
H
SEV
N
-
-
-
LPIDF
L
V
--
NQT
----
--
--
--
--
--
LT
L
G
T
EWNQQ
R
M
KDLSS
N
TQA
L
TGA
N
T
---
GGA
I
--
D
G
V
S
A
TD
------------------
R
S
P
Y
SK
AE
I
F
S
L
F
A
EN
N
ME
LTD
S
T
I
V
T
P
GLRFD
H
H
SIVGN
N
WS
PALNISQGL
GD
D
-
---F
T
LKM
G
I
A
RA
----------------
Y
KA
P
S
LY
Q
TN
P
N
--
-
YI
L
Y
S
----
-
K
G
Q
G
CY
A
--
S
AG
GCYLQGND
D
L
KAE
T
SIN
K
EIG
L
EFK
RD
G
-
-
W
L
AG
V
T
W
FR
N
D
YR
NKIE
A
G
Y
V
AV
G
QN
AV
GT
DLYQ
W
D
N
V
P
KA
V
VEG
L
E
G
S
LN---V
P
-
VSE
TVM
W
TN
N
I
T
Y
MLK
S
E
N
K
T
T
----
-
-
-----
GDRL
S
II
PEY
TLN
S
TLSW
QA
RE
D
L
S
M
Q
TTF
T
W
YG
KQQ
P
KKY
-
N
Y
KG
QPAVG
P
ETKEIS
P
-
Y
SIV
G
L
S
AT
W
D
VTKN
V
S
LTGG
VDNLFD
K
R
L
WRAGNA
Q
T
T
G
DLA
GANY
I
A
GA
G
AYT
Y
N
-
E
PG
--
RT
WY
M
SV
NTHF
fig|6666666.5357.peg.1810
Escherichia coli TY-2482
MNKKIHSL
A
LLVNL
G
IYGVA
--
-
Q
A
Q
EP
TD
TPVSH
DDT
I
VVTA
-
A
E
Q
N
L
-
Q
AP
GV
S
---
-------------
T
I
T
A
DEIR
K
N
P
V
A
R
DVS
E
II
R
T
MPGVN
L
---
--
TGNST
S
G
Q
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
K
P
VS
S
R
NSV
RQGW
RGE
RDT
RG
DTSWVPPEM
I
E
R
I
EVLRGP
A
AA
R
YG
N
G
A
A
GG
V
V
NIITK
KG
SGEWH
G
SW
D
A
Y
F
NA
PE
H
KEEGATK
R
TN
FSLTGP
L
-
GD
EFSF
RLYG
NLD
--
KT
Q
A
D
AWD
IN
Q
--
G
HQSAR
AGTYATTLP
AGR
EG
V
I
N
K
DINGV
VR
WDF
AP
LQ
S
LELEA
G
YSRQGN
L
-
Y
AGD
TQ
NTNS
D
---------------
AY
T
RS
--
KY
G
D
-
E
T
NRL
Y
RQ
NY
A
LTWN
GG
WD
N
G
V
T
T
S
NWVQY
EH
-----------
TR
N
SR
IP
E
-
----
G
LA
G
-----
G
TEGKFNEK
A
TQDFVDI
D
L
D
D
V
M
L
H
SEV
N
-
-
-
LPIDF
L
V
--
NQT
----
--
--
--
--
--
LT
L
G
T
EWNQQ
R
M
KDLSS
N
TQA
L
TGA
N
T
---
GGA
I
--
D
G
V
S
A
TD
------------------
R
S
P
Y
SK
AE
I
F
S
L
F
A
EN
N
ME
LTD
S
T
I
V
T
P
GLRFD
H
H
SIVGN
N
WS
PALNISQGL
GD
D
-
---F
T
LKM
G
I
A
RA
----------------
Y
KA
P
S
LY
Q
TN
P
N
--
-
YI
L
Y
S
----
-
K
G
Q
G
CY
A
--
S
AG
GCYLQGND
D
L
KAE
T
SIN
K
EIG
L
EFK
RD
G
-
-
W
L
AG
V
T
W
FR
N
D
YR
NKIE
A
G
Y
V
AV
G
QN
AV
GT
DLYQ
W
D
N
V
P
KA
V
VEG
L
E
G
S
LN---V
P
-
VSE
TVM
W
TN
N
I
T
Y
MLK
S
E
N
K
T
T
----
-
-
-----
GDRL
S
II
PEY
TLN
S
TLSW
QA
RE
D
L
S
M
Q
TTF
T
W
YG
KQQ
P
KKY
-
N
Y
KG
QPAVG
P
ETKEIS
P
-
Y
SIV
G
L
S
AT
W
D
VTKN
V
S
LTGG
VDNLFD
K
R
L
WRAGNA
Q
T
T
G
DLA
GANY
I
A
GA
G
AYT
Y
N
-
E
PG
--
RT
WY
M
SV
NTHF
fig|585055.6.peg.586
Escherichia coli 55989
MNKKIHSL
A
LLVNL
G
IYGVA
--
-
Q
A
Q
EP
TD
TPVSH
DDT
I
VVTA
-
A
E
Q
N
L
-
Q
AP
GV
S
---
-------------
T
I
T
A
DEIR
K
N
P
V
A
R
DVS
E
II
R
T
MPGVN
L
---
--
TGNST
S
G
Q
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
K
P
VS
S
R
NSV
RQGW
RGE
RDT
RG
DTSWVPPEM
I
E
R
I
EVLRGP
A
AA
R
YG
N
G
A
A
GG
V
V
NIITK
KG
SGEWH
G
SW
D
A
Y
F
NA
PE
H
KEEGATK
R
TN
FSLTGP
L
-
GD
EFSF
RLYG
NLD
--
KT
Q
A
D
AWD
IN
Q
--
G
HQSAR
AGTYATTLP
AGR
EG
V
I
N
K
DINGV
VR
WDF
AP
LQ
S
LELEA
G
YSRQGN
L
-
Y
AGD
TQ
NTNS
D
---------------
AY
T
RS
--
KY
G
D
-
E
T
NRL
Y
RQ
NY
A
LTWN
GG
WD
N
G
V
T
T
S
NWVQY
EH
-----------
TR
N
SR
IP
E
-
----
G
LA
G
-----
G
TEGKFNEK
A
TQDFVDI
D
L
D
D
V
M
L
H
SEV
N
-
-
-
LPIDF
L
V
--
NQT
----
--
--
--
--
--
LT
L
G
T
EWNQQ
R
M
KDLSS
N
TQA
L
TGA
N
T
---
GGA
I
--
D
G
V
S
A
TD
------------------
R
S
P
Y
SK
AE
I
F
S
L
F
A
EN
N
ME
LTD
S
T
I
V
T
P
GLRFD
H
H
SIVGN
N
WS
PALNISQGL
GD
D
-
---F
T
LKM
G
I
A
RA
----------------
Y
KA
P
S
LY
Q
TN
P
N
--
-
YI
L
Y
S
----
-
K
G
Q
G
CY
A
--
S
AG
GCYLQGND
D
L
KAE
T
SIN
K
EIG
L
EFK
RD
G
-
-
W
L
AG
V
T
W
FR
N
D
YR
NKIE
A
G
Y
V
AV
G
QN
AV
GT
DLYQ
W
D
N
V
P
KA
V
VEG
L
E
G
S
LN---V
P
-
VSE
TVM
W
TN
N
I
T
Y
MLK
S
E
N
K
T
T
----
-
-
-----
GDRL
S
II
PEY
TLN
S
TLSW
QA
RE
D
L
S
M
Q
TTF
T
W
YG
KQQ
P
KKY
-
N
Y
KG
QPAVG
P
ETKEIS
P
-
Y
SIV
G
L
S
AT
W
D
VTKN
V
S
LTGG
VDNLFD
K
R
L
WRAGNA
Q
T
T
G
DLA
GANY
I
A
GA
G
AYT
Y
N
-
E
PG
--
RT
WY
M
SV
NTHF
fig|585055.8.peg.587
Escherichia coli 55989
MNKKIHSL
A
LLVNL
G
IYGVA
--
-
Q
A
Q
EP
TD
TPVSH
DDT
I
VVTA
-
A
E
Q
N
L
-
Q
AP
GV
S
---
-------------
T
I
T
A
DEIR
K
N
P
V
A
R
DVS
E
II
R
T
MPGVN
L
---
--
TGNST
S
G
Q
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
K
P
VS
S
R
NSV
RQGW
RGE
RDT
RG
DTSWVPPEM
I
E
R
I
EVLRGP
A
AA
R
YG
N
G
A
A
GG
V
V
NIITK
KG
SGEWH
G
SW
D
A
Y
F
NA
PE
H
KEEGATK
R
TN
FSLTGP
L
-
GD
EFSF
RLYG
NLD
--
KT
Q
A
D
AWD
IN
Q
--
G
HQSAR
AGTYATTLP
AGR
EG
V
I
N
K
DINGV
VR
WDF
AP
LQ
S
LELEA
G
YSRQGN
L
-
Y
AGD
TQ
NTNS
D
---------------
AY
T
RS
--
KY
G
D
-
E
T
NRL
Y
RQ
NY
A
LTWN
GG
WD
N
G
V
T
T
S
NWVQY
EH
-----------
TR
N
SR
IP
E
-
----
G
LA
G
-----
G
TEGKFNEK
A
TQDFVDI
D
L
D
D
V
M
L
H
SEV
N
-
-
-
LPIDF
L
V
--
NQT
----
--
--
--
--
--
LT
L
G
T
EWNQQ
R
M
KDLSS
N
TQA
L
TGA
N
T
---
GGA
I
--
D
G
V
S
A
TD
------------------
R
S
P
Y
SK
AE
I
F
S
L
F
A
EN
N
ME
LTD
S
T
I
V
T
P
GLRFD
H
H
SIVGN
N
WS
PALNISQGL
GD
D
-
---F
T
LKM
G
I
A
RA
----------------
Y
KA
P
S
LY
Q
TN
P
N
--
-
YI
L
Y
S
----
-
K
G
Q
G
CY
A
--
S
AG
GCYLQGND
D
L
KAE
T
SIN
K
EIG
L
EFK
RD
G
-
-
W
L
AG
V
T
W
FR
N
D
YR
NKIE
A
G
Y
V
AV
G
QN
AV
GT
DLYQ
W
D
N
V
P
KA
V
VEG
L
E
G
S
LN---V
P
-
VSE
TVM
W
TN
N
I
T
Y
MLK
S
E
N
K
T
T
----
-
-
-----
GDRL
S
II
PEY
TLN
S
TLSW
QA
RE
D
L
S
M
Q
TTF
T
W
YG
KQQ
P
KKY
-
N
Y
KG
QPAVG
P
ETKEIS
P
-
Y
SIV
G
L
S
AT
W
D
VTKN
V
S
LTGG
VDNLFD
K
R
L
WRAGNA
Q
T
T
G
DLA
GANY
I
A
GA
G
AYT
Y
N
-
E
PG
--
RT
WY
M
SV
NTHF
fig|550672.3.peg.151
Escherichia coli B088
MNKKIHSL
A
LLVNL
G
IYGVA
--
-
Q
A
Q
EP
TD
TPVSH
DDT
I
VVTA
-
A
E
Q
N
L
-
Q
AP
GV
S
---
-------------
T
I
T
A
DEIR
K
N
P
V
A
R
DVS
E
II
R
T
MPGVN
L
---
--
TGNST
S
G
Q
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
K
P
VS
S
R
NSV
RQGW
RGE
RDT
RG
DTSWVPPEM
I
E
R
I
EVLRGP
A
AA
R
YG
N
G
A
A
GG
V
V
NIITK
KG
SGEWH
G
SW
D
A
Y
F
NA
PE
H
KEEGATK
R
TN
FSLTGP
L
-
GD
EFSF
RLYG
NLD
--
KT
Q
A
D
AWD
IN
Q
--
G
HQSAR
AGTYATTLP
AGR
EG
V
I
N
K
DINGV
VR
WDF
AP
LQ
S
LELEA
G
YSRQGN
L
-
Y
AGD
TQ
NTNS
D
---------------
AY
T
RS
--
KY
G
D
-
E
T
NRL
Y
RQ
NY
A
LTWN
GG
WD
N
G
V
T
T
S
NWVQY
EH
-----------
TR
N
SR
IP
E
-
----
G
LA
G
-----
G
TEGKFNEK
A
TQDFVDI
D
L
D
D
V
M
L
H
SEV
N
-
-
-
LPIDF
L
V
--
NQT
----
--
--
--
--
--
LT
L
G
T
EWNQQ
R
M
KDLSS
N
TQA
L
TGA
N
T
---
GGA
I
--
D
G
V
S
A
TD
------------------
R
S
P
Y
SK
AE
I
F
S
L
F
A
EN
N
ME
LTD
S
T
I
V
T
P
GLRFD
H
H
SIVGN
N
WS
PALNISQGL
GD
D
-
---F
T
LKM
G
I
A
RA
----------------
Y
KA
P
S
LY
Q
TN
P
N
--
-
YI
L
Y
S
----
-
K
G
Q
G
CY
A
--
S
AG
GCYLQGND
D
L
KAE
T
SIN
K
EIG
L
EFK
RD
G
-
-
W
L
AG
V
T
W
FR
N
D
YR
NKIE
A
G
Y
V
AV
G
QN
AV
GT
DLYQ
W
D
N
V
P
KA
V
VEG
L
E
G
S
LN---V
P
-
VSE
TVM
W
TN
N
I
T
Y
MLK
S
E
N
K
T
T
----
-
-
-----
GDRL
S
II
PEY
TLN
S
TLSW
QA
RE
D
L
S
M
Q
TTF
T
W
YG
KQQ
P
KKY
-
N
Y
KG
QPAVG
P
ETKEIS
P
-
Y
SIV
G
L
S
AT
W
D
VTKN
V
S
LTGG
VDNLFD
K
R
L
WRAGNA
Q
T
T
G
DLA
GANY
I
A
GA
G
AYT
Y
N
-
E
PG
--
RT
WY
M
SV
NTHF
fig|340184.3.peg.2457
Escherichia coli B7A
MNKKIHSL
A
LLVNL
G
IYGVA
--
-
Q
A
Q
EP
TD
TPVSH
DDT
I
VVTA
-
A
E
Q
N
L
-
Q
AP
GV
S
---
-------------
T
I
T
A
DEIR
K
N
P
V
A
R
DVS
E
II
R
T
MPGVN
L
---
--
TGNST
S
G
Q
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
K
P
VS
S
R
NSV
RQGW
RGE
RDT
RG
DTSWVPPEM
I
E
R
I
EVLRGP
A
AA
R
YG
N
G
A
A
GG
V
V
NIITK
KG
SGEWH
G
SW
D
A
Y
F
NA
PE
H
KEEGATK
R
TN
FSLTGP
L
-
GD
EFSF
RLYG
NLD
--
KT
Q
A
D
AWD
IN
Q
--
G
HQSAR
AGTYATTLP
AGR
EG
V
I
N
K
DINGV
VR
WDF
AP
LQ
S
LELEA
G
YSRQGN
L
-
Y
AGD
TQ
NTNS
D
---------------
AY
T
RS
--
KY
G
D
-
E
T
NRL
Y
RQ
NY
A
LTWN
GG
WD
N
G
V
T
T
S
NWVQY
EH
-----------
TR
N
SR
IP
E
-
----
G
LA
G
-----
G
TEGKFNEK
A
TQDFVDI
D
L
D
D
V
M
L
H
SEV
N
-
-
-
LPIDF
L
V
--
NQT
----
--
--
--
--
--
LT
L
G
T
EWNQQ
R
M
KDLSS
N
TQA
L
TGA
N
T
---
GGA
I
--
D
G
V
S
A
TD
------------------
R
S
P
Y
SK
AE
I
F
S
L
F
A
EN
N
ME
LTD
S
T
I
V
T
P
GLRFD
H
H
SIVGN
N
WS
PALNISQGL
GD
D
-
---F
T
LKM
G
I
A
RA
----------------
Y
KA
P
S
LY
Q
TN
P
N
--
-
YI
L
Y
S
----
-
K
G
Q
G
CY
A
--
S
AG
GCYLQGND
D
L
KAE
T
SIN
K
EIG
L
EFK
RD
G
-
-
W
L
AG
V
T
W
FR
N
D
YR
NKIE
A
G
Y
V
AV
G
QN
AV
GT
DLYQ
W
D
N
V
P
KA
V
VEG
L
E
G
S
LN---V
P
-
VSE
TVM
W
TN
N
I
T
Y
MLK
S
E
N
K
T
T
----
-
-
-----
GDRL
S
II
PEY
TLN
S
TLSW
QA
RE
D
L
S
M
Q
TTF
T
W
YG
KQQ
P
KKY
-
N
Y
KG
QPAVG
P
ETKEIS
P
-
Y
SIV
G
L
S
AT
W
D
VTKN
V
S
LTGG
VDNLFD
K
R
L
WRAGNA
Q
T
T
G
DLA
GANY
I
A
GA
G
AYT
Y
N
-
E
PG
--
RT
WY
M
SV
NTHF
fig|340184.6.peg.2576
Escherichia coli B7A
MNKKIHSL
A
LLVNL
G
IYGVA
--
-
Q
A
Q
EP
TD
TPVSH
DDT
I
VVTA
-
A
E
Q
N
L
-
Q
AP
GV
S
---
-------------
T
I
T
A
DEIR
K
N
P
V
A
R
DVS
E
II
R
T
MPGVN
L
---
--
TGNST
S
G
Q
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
K
P
VS
S
R
NSV
RQGW
RGE
RDT
RG
DTSWVPPEM
I
E
R
I
EVLRGP
A
AA
R
YG
N
G
A
A
GG
V
V
NIITK
KG
SGEWH
G
SW
D
A
Y
F
NA
PE
H
KEEGATK
R
TN
FSLTGP
L
-
GD
EFSF
RLYG
NLD
--
KT
Q
A
D
AWD
IN
Q
--
G
HQSAR
AGTYATTLP
AGR
EG
V
I
N
K
DINGV
VR
WDF
AP
LQ
S
LELEA
G
YSRQGN
L
-
Y
AGD
TQ
NTNS
D
---------------
AY
T
RS
--
KY
G
D
-
E
T
NRL
Y
RQ
NY
A
LTWN
GG
WD
N
G
V
T
T
S
NWVQY
EH
-----------
TR
N
SR
IP
E
-
----
G
LA
G
-----
G
TEGKFNEK
A
TQDFVDI
D
L
D
D
V
M
L
H
SEV
N
-
-
-
LPIDF
L
V
--
NQT
----
--
--
--
--
--
LT
L
G
T
EWNQQ
R
M
KDLSS
N
TQA
L
TGA
N
T
---
GGA
I
--
D
G
V
S
A
TD
------------------
R
S
P
Y
SK
AE
I
F
S
L
F
A
EN
N
ME
LTD
S
T
I
V
T
P
GLRFD
H
H
SIVGN
N
WS
PALNISQGL
GD
D
-
---F
T
LKM
G
I
A
RA
----------------
Y
KA
P
S
LY
Q
TN
P
N
--
-
YI
L
Y
S
----
-
K
G
Q
G
CY
A
--
S
AG
GCYLQGND
D
L
KAE
T
SIN
K
EIG
L
EFK
RD
G
-
-
W
L
AG
V
T
W
FR
N
D
YR
NKIE
A
G
Y
V
AV
G
QN
AV
GT
DLYQ
W
D
N
V
P
KA
V
VEG
L
E
G
S
LN---V
P
-
VSE
TVM
W
TN
N
I
T
Y
MLK
S
E
N
K
T
T
----
-
-
-----
GDRL
S
II
PEY
TLN
S
TLSW
QA
RE
D
L
S
M
Q
TTF
T
W
YG
KQQ
P
KKY
-
N
Y
KG
QPAVG
P
ETKEIS
P
-
Y
SIV
G
L
S
AT
W
D
VTKN
V
S
LTGG
VDNLFD
K
R
L
WRAGNA
Q
T
T
G
DLA
GANY
I
A
GA
G
AYT
Y
N
-
E
PG
--
RT
WY
M
SV
NTHF
fig|340186.3.peg.2236
Escherichia coli E110019
MNKKIHSL
A
LLVNL
G
IYGVA
--
-
Q
A
Q
EP
TD
TPVSH
DDT
I
VVTA
-
A
E
Q
N
L
-
Q
AP
GV
S
---
-------------
T
I
T
A
DEIR
K
N
P
V
A
R
DVS
E
II
R
T
MPGVN
L
---
--
TGNST
S
G
Q
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
K
P
VS
S
R
NSV
RQGW
RGE
RDT
RG
DTSWVPPEM
I
E
R
I
EVLRGP
A
AA
R
YG
N
G
A
A
GG
V
V
NIITK
KG
SGEWH
G
SW
D
A
Y
F
NA
PE
H
KEEGATK
R
TN
FSLTGP
L
-
GD
EFSF
RLYG
NLD
--
KT
Q
A
D
AWD
IN
Q
--
G
HQSAR
AGTYATTLP
AGR
EG
V
I
N
K
DINGV
VR
WDF
AP
LQ
S
LELEA
G
YSRQGN
L
-
Y
AGD
TQ
NTNS
D
---------------
AY
T
RS
--
KY
G
D
-
E
T
NRL
Y
RQ
NY
A
LTWN
GG
WD
N
G
V
T
T
S
NWVQY
EH
-----------
TR
N
SR
IP
E
-
----
G
LA
G
-----
G
TEGKFNEK
A
TQDFVDI
D
L
D
D
V
M
L
H
SEV
N
-
-
-
LPIDF
L
V
--
NQT
----
--
--
--
--
--
LT
L
G
T
EWNQQ
R
M
KDLSS
N
TQA
L
TGA
N
T
---
GGA
I
--
D
G
V
S
A
TD
------------------
R
S
P
Y
SK
AE
I
F
S
L
F
A
EN
N
ME
LTD
S
T
I
V
T
P
GLRFD
H
H
SIVGN
N
WS
PALNISQGL
GD
D
-
---F
T
LKM
G
I
A
RA
----------------
Y
KA
P
S
LY
Q
TN
P
N
--
-
YI
L
Y
S
----
-
K
G
Q
G
CY
A
--
S
AG
GCYLQGND
D
L
KAE
T
SIN
K
EIG
L
EFK
RD
G
-
-
W
L
AG
V
T
W
FR
N
D
YR
NKIE
A
G
Y
V
AV
G
QN
AV
GT
DLYQ
W
D
N
V
P
KA
V
VEG
L
E
G
S
LN---V
P
-
VSE
TVM
W
TN
N
I
T
Y
MLK
S
E
N
K
T
T
----
-
-
-----
GDRL
S
II
PEY
TLN
S
TLSW
QA
RE
D
L
S
M
Q
TTF
T
W
YG
KQQ
P
KKY
-
N
Y
KG
QPAVG
P
ETKEIS
P
-
Y
SIV
G
L
S
AT
W
D
VTKN
V
S
LTGG
VDNLFD
K
R
L
WRAGNA
Q
T
T
G
DLA
GANY
I
A
GA
G
AYT
Y
N
-
E
PG
--
RT
WY
M
SV
NTHF
fig|340186.5.peg.2310
Escherichia coli E110019
MNKKIHSL
A
LLVNL
G
IYGVA
--
-
Q
A
Q
EP
TD
TPVSH
DDT
I
VVTA
-
A
E
Q
N
L
-
Q
AP
GV
S
---
-------------
T
I
T
A
DEIR
K
N
P
V
A
R
DVS
E
II
R
T
MPGVN
L
---
--
TGNST
S
G
Q
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
K
P
VS
S
R
NSV
RQGW
RGE
RDT
RG
DTSWVPPEM
I
E
R
I
EVLRGP
A
AA
R
YG
N
G
A
A
GG
V
V
NIITK
KG
SGEWH
G
SW
D
A
Y
F
NA
PE
H
KEEGATK
R
TN
FSLTGP
L
-
GD
EFSF
RLYG
NLD
--
KT
Q
A
D
AWD
IN
Q
--
G
HQSAR
AGTYATTLP
AGR
EG
V
I
N
K
DINGV
VR
WDF
AP
LQ
S
LELEA
G
YSRQGN
L
-
Y
AGD
TQ
NTNS
D
---------------
AY
T
RS
--
KY
G
D
-
E
T
NRL
Y
RQ
NY
A
LTWN
GG
WD
N
G
V
T
T
S
NWVQY
EH
-----------
TR
N
SR
IP
E
-
----
G
LA
G
-----
G
TEGKFNEK
A
TQDFVDI
D
L
D
D
V
M
L
H
SEV
N
-
-
-
LPIDF
L
V
--
NQT
----
--
--
--
--
--
LT
L
G
T
EWNQQ
R
M
KDLSS
N
TQA
L
TGA
N
T
---
GGA
I
--
D
G
V
S
A
TD
------------------
R
S
P
Y
SK
AE
I
F
S
L
F
A
EN
N
ME
LTD
S
T
I
V
T
P
GLRFD
H
H
SIVGN
N
WS
PALNISQGL
GD
D
-
---F
T
LKM
G
I
A
RA
----------------
Y
KA
P
S
LY
Q
TN
P
N
--
-
YI
L
Y
S
----
-
K
G
Q
G
CY
A
--
S
AG
GCYLQGND
D
L
KAE
T
SIN
K
EIG
L
EFK
RD
G
-
-
W
L
AG
V
T
W
FR
N
D
YR
NKIE
A
G
Y
V
AV
G
QN
AV
GT
DLYQ
W
D
N
V
P
KA
V
VEG
L
E
G
S
LN---V
P
-
VSE
TVM
W
TN
N
I
T
Y
MLK
S
E
N
K
T
T
----
-
-
-----
GDRL
S
II
PEY
TLN
S
TLSW
QA
RE
D
L
S
M
Q
TTF
T
W
YG
KQQ
P
KKY
-
N
Y
KG
QPAVG
P
ETKEIS
P
-
Y
SIV
G
L
S
AT
W
D
VTKN
V
S
LTGG
VDNLFD
K
R
L
WRAGNA
Q
T
T
G
DLA
GANY
I
A
GA
G
AYT
Y
N
-
E
PG
--
RT
WY
M
SV
NTHF
fig|562.375.peg.1576
Escherichia coli EC4100B
MNKKIHSL
A
LLVNL
G
IYGVA
--
-
Q
A
Q
EP
TD
TPVSH
DDT
I
VVTA
-
A
E
Q
N
L
-
Q
AP
GV
S
---
-------------
T
I
T
A
DEIR
K
N
P
V
A
R
DVS
E
II
R
T
MPGVN
L
---
--
TGNST
S
G
Q
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
K
P
VS
S
R
NSV
RQGW
RGE
RDT
RG
DTSWVPPEM
I
E
R
I
EVLRGP
A
AA
R
YG
N
G
A
A
GG
V
V
NIITK
KG
SGEWH
G
SW
D
A
Y
F
NA
PE
H
KEEGATK
R
TN
FSLTGP
L
-
GD
EFSF
RLYG
NLD
--
KT
Q
A
D
AWD
IN
Q
--
G
HQSAR
AGTYATTLP
AGR
EG
V
I
N
K
DINGV
VR
WDF
AP
LQ
S
LELEA
G
YSRQGN
L
-
Y
AGD
TQ
NTNS
D
---------------
AY
T
RS
--
KY
G
D
-
E
T
NRL
Y
RQ
NY
A
LTWN
GG
WD
N
G
V
T
T
S
NWVQY
EH
-----------
TR
N
SR
IP
E
-
----
G
LA
G
-----
G
TEGKFNEK
A
TQDFVDI
D
L
D
D
V
M
L
H
SEV
N
-
-
-
LPIDF
L
V
--
NQT
----
--
--
--
--
--
LT
L
G
T
EWNQQ
R
M
KDLSS
N
TQA
L
TGA
N
T
---
GGA
I
--
D
G
V
S
A
TD
------------------
R
S
P
Y
SK
AE
I
F
S
L
F
A
EN
N
ME
LTD
S
T
I
V
T
P
GLRFD
H
H
SIVGN
N
WS
PALNISQGL
GD
D
-
---F
T
LKM
G
I
A
RA
----------------
Y
KA
P
S
LY
Q
TN
P
N
--
-
YI
L
Y
S
----
-
K
G
Q
G
CY
A
--
S
AG
GCYLQGND
D
L
KAE
T
SIN
K
EIG
L
EFK
RD
G
-
-
W
L
AG
V
T
W
FR
N
D
YR
NKIE
A
G
Y
V
AV
G
QN
AV
GT
DLYQ
W
D
N
V
P
KA
V
VEG
L
E
G
S
LN---V
P
-
VSE
TVM
W
TN
N
I
T
Y
MLK
S
E
N
K
T
T
----
-
-
-----
GDRL
S
II
PEY
TLN
S
TLSW
QA
RE
D
L
S
M
Q
TTF
T
W
YG
KQQ
P
KKY
-
N
Y
KG
QPAVG
P
ETKEIS
P
-
Y
SIV
G
L
S
AT
W
D
VTKN
V
S
LTGG
VDNLFD
K
R
L
WRAGNA
Q
T
T
G
DLA
GANY
I
A
GA
G
AYT
Y
N
-
E
PG
--
RT
WY
M
SV
NTHF
fig|585034.4.peg.560
Escherichia coli IAI1
MNKKIHSL
A
LLVNL
G
IYGVA
--
-
Q
A
Q
EP
TD
TPVSH
DDT
I
VVTA
-
A
E
Q
N
L
-
Q
AP
GV
S
---
-------------
T
I
T
A
DEIR
K
N
P
V
A
R
DVS
E
II
R
T
MPGVN
L
---
--
TGNST
S
G
Q
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
K
P
VS
S
R
NSV
RQGW
RGE
RDT
RG
DTSWVPPEM
I
E
R
I
EVLRGP
A
AA
R
YG
N
G
A
A
GG
V
V
NIITK
KG
SGEWH
G
SW
D
A
Y
F
NA
PE
H
KEEGATK
R
TN
FSLTGP
L
-
GD
EFSF
RLYG
NLD
--
KT
Q
A
D
AWD
IN
Q
--
G
HQSAR
AGTYATTLP
AGR
EG
V
I
N
K
DINGV
VR
WDF
AP
LQ
S
LELEA
G
YSRQGN
L
-
Y
AGD
TQ
NTNS
D
---------------
AY
T
RS
--
KY
G
D
-
E
T
NRL
Y
RQ
NY
A
LTWN
GG
WD
N
G
V
T
T
S
NWVQY
EH
-----------
TR
N
SR
IP
E
-
----
G
LA
G
-----
G
TEGKFNEK
A
TQDFVDI
D
L
D
D
V
M
L
H
SEV
N
-
-
-
LPIDF
L
V
--
NQT
----
--
--
--
--
--
LT
L
G
T
EWNQQ
R
M
KDLSS
N
TQA
L
TGA
N
T
---
GGA
I
--
D
G
V
S
A
TD
------------------
R
S
P
Y
SK
AE
I
F
S
L
F
A
EN
N
ME
LTD
S
T
I
V
T
P
GLRFD
H
H
SIVGN
N
WS
PALNISQGL
GD
D
-
---F
T
LKM
G
I
A
RA
----------------
Y
KA
P
S
LY
Q
TN
P
N
--
-
YI
L
Y
S
----
-
K
G
Q
G
CY
A
--
S
AG
GCYLQGND
D
L
KAE
T
SIN
K
EIG
L
EFK
RD
G
-
-
W
L
AG
V
T
W
FR
N
D
YR
NKIE
A
G
Y
V
AV
G
QN
AV
GT
DLYQ
W
D
N
V
P
KA
V
VEG
L
E
G
S
LN---V
P
-
VSE
TVM
W
TN
N
I
T
Y
MLK
S
E
N
K
T
T
----
-
-
-----
GDRL
S
II
PEY
TLN
S
TLSW
QA
RE
D
L
S
M
Q
TTF
T
W
YG
KQQ
P
KKY
-
N
Y
KG
QPAVG
P
ETKEIS
P
-
Y
SIV
G
L
S
AT
W
D
VTKN
V
S
LTGG
VDNLFD
K
R
L
WRAGNA
Q
T
T
G
DLA
GANY
I
A
GA
G
AYT
Y
N
-
E
PG
--
RT
WY
M
SV
NTHF
fig|585034.5.peg.559
Escherichia coli IAI1
MNKKIHSL
A
LLVNL
G
IYGVA
--
-
Q
A
Q
EP
TD
TPVSH
DDT
I
VVTA
-
A
E
Q
N
L
-
Q
AP
GV
S
---
-------------
T
I
T
A
DEIR
K
N
P
V
A
R
DVS
E
II
R
T
MPGVN
L
---
--
TGNST
S
G
Q
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
K
P
VS
S
R
NSV
RQGW
RGE
RDT
RG
DTSWVPPEM
I
E
R
I
EVLRGP
A
AA
R
YG
N
G
A
A
GG
V
V
NIITK
KG
SGEWH
G
SW
D
A
Y
F
NA
PE
H
KEEGATK
R
TN
FSLTGP
L
-
GD
EFSF
RLYG
NLD
--
KT
Q
A
D
AWD
IN
Q
--
G
HQSAR
AGTYATTLP
AGR
EG
V
I
N
K
DINGV
VR
WDF
AP
LQ
S
LELEA
G
YSRQGN
L
-
Y
AGD
TQ
NTNS
D
---------------
AY
T
RS
--
KY
G
D
-
E
T
NRL
Y
RQ
NY
A
LTWN
GG
WD
N
G
V
T
T
S
NWVQY
EH
-----------
TR
N
SR
IP
E
-
----
G
LA
G
-----
G
TEGKFNEK
A
TQDFVDI
D
L
D
D
V
M
L
H
SEV
N
-
-
-
LPIDF
L
V
--
NQT
----
--
--
--
--
--
LT
L
G
T
EWNQQ
R
M
KDLSS
N
TQA
L
TGA
N
T
---
GGA
I
--
D
G
V
S
A
TD
------------------
R
S
P
Y
SK
AE
I
F
S
L
F
A
EN
N
ME
LTD
S
T
I
V
T
P
GLRFD
H
H
SIVGN
N
WS
PALNISQGL
GD
D
-
---F
T
LKM
G
I
A
RA
----------------
Y
KA
P
S
LY
Q
TN
P
N
--
-
YI
L
Y
S
----
-
K
G
Q
G
CY
A
--
S
AG
GCYLQGND
D
L
KAE
T
SIN
K
EIG
L
EFK
RD
G
-
-
W
L
AG
V
T
W
FR
N
D
YR
NKIE
A
G
Y
V
AV
G
QN
AV
GT
DLYQ
W
D
N
V
P
KA
V
VEG
L
E
G
S
LN---V
P
-
VSE
TVM
W
TN
N
I
T
Y
MLK
S
E
N
K
T
T
----
-
-
-----
GDRL
S
II
PEY
TLN
S
TLSW
QA
RE
D
L
S
M
Q
TTF
T
W
YG
KQQ
P
KKY
-
N
Y
KG
QPAVG
P
ETKEIS
P
-
Y
SIV
G
L
S
AT
W
D
VTKN
V
S
LTGG
VDNLFD
K
R
L
WRAGNA
Q
T
T
G
DLA
GANY
I
A
GA
G
AYT
Y
N
-
E
PG
--
RT
WY
M
SV
NTHF
fig|595495.4.peg.2033
Escherichia coli KO11
MNKKIHSL
A
LLVNL
G
IYGVA
--
-
Q
A
Q
EP
TD
TPVSH
DDT
I
VVTA
-
A
E
Q
N
L
-
Q
AP
GV
S
---
-------------
T
I
T
A
DEIR
K
N
P
V
A
R
DVS
E
II
R
T
MPGVN
L
---
--
TGNST
S
G
Q
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
K
P
VS
S
R
NSV
RQGW
RGE
RDT
RG
DTSWVPPEM
I
E
R
I
EVLRGP
A
AA
R
YG
N
G
A
A
GG
V
V
NIITK
KG
SGEWH
G
SW
D
A
Y
F
NA
PE
H
KEEGATK
R
TN
FSLTGP
L
-
GD
EFSF
RLYG
NLD
--
KT
Q
A
D
AWD
IN
Q
--
G
HQSAR
AGTYATTLP
AGR
EG
V
I
N
K
DINGV
VR
WDF
AP
LQ
S
LELEA
G
YSRQGN
L
-
Y
AGD
TQ
NTNS
D
---------------
AY
T
RS
--
KY
G
D
-
E
T
NRL
Y
RQ
NY
A
LTWN
GG
WD
N
G
V
T
T
S
NWVQY
EH
-----------
TR
N
SR
IP
E
-
----
G
LA
G
-----
G
TEGKFNEK
A
TQDFVDI
D
L
D
D
V
M
L
H
SEV
N
-
-
-
LPIDF
L
V
--
NQT
----
--
--
--
--
--
LT
L
G
T
EWNQQ
R
M
KDLSS
N
TQA
L
TGA
N
T
---
GGA
I
--
D
G
V
S
A
TD
------------------
R
S
P
Y
SK
AE
I
F
S
L
F
A
EN
N
ME
LTD
S
T
I
V
T
P
GLRFD
H
H
SIVGN
N
WS
PALNISQGL
GD
D
-
---F
T
LKM
G
I
A
RA
----------------
Y
KA
P
S
LY
Q
TN
P
N
--
-
YI
L
Y
S
----
-
K
G
Q
G
CY
A
--
S
AG
GCYLQGND
D
L
KAE
T
SIN
K
EIG
L
EFK
RD
G
-
-
W
L
AG
V
T
W
FR
N
D
YR
NKIE
A
G
Y
V
AV
G
QN
AV
GT
DLYQ
W
D
N
V
P
KA
V
VEG
L
E
G
S
LN---V
P
-
VSE
TVM
W
TN
N
I
T
Y
MLK
S
E
N
K
T
T
----
-
-
-----
GDRL
S
II
PEY
TLN
S
TLSW
QA
RE
D
L
S
M
Q
TTF
T
W
YG
KQQ
P
KKY
-
N
Y
KG
QPAVG
P
ETKEIS
P
-
Y
SIV
G
L
S
AT
W
D
VTKN
V
S
LTGG
VDNLFD
K
R
L
WRAGNA
Q
T
T
G
DLA
GANY
I
A
GA
G
AYT
Y
N
-
E
PG
--
RT
WY
M
SV
NTHF
fig|679206.4.peg.2887
Escherichia coli MS 119-7
MNKKIHSL
A
LLVNL
G
IYGVA
--
-
Q
A
Q
EP
TD
TPVSH
DDT
I
VVTA
-
A
E
Q
N
L
-
Q
AP
GV
S
---
-------------
T
I
T
A
DEIR
K
N
P
V
A
R
DVS
E
II
R
T
MPGVN
L
---
--
TGNST
S
G
Q
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
K
P
VS
S
R
NSV
RQGW
RGE
RDT
RG
DTSWVPPEM
I
E
R
I
EVLRGP
A
AA
R
YG
N
G
A
A
GG
V
V
NIITK
KG
SGEWH
G
SW
D
A
Y
F
NA
PE
H
KEEGATK
R
TN
FSLTGP
L
-
GD
EFSF
RLYG
NLD
--
KT
Q
A
D
AWD
IN
Q
--
G
HQSAR
AGTYATTLP
AGR
EG
V
I
N
K
DINGV
VR
WDF
AP
LQ
S
LELEA
G
YSRQGN
L
-
Y
AGD
TQ
NTNS
D
---------------
AY
T
RS
--
KY
G
D
-
E
T
NRL
Y
RQ
NY
A
LTWN
GG
WD
N
G
V
T
T
S
NWVQY
EH
-----------
TR
N
SR
IP
E
-
----
G
LA
G
-----
G
TEGKFNEK
A
TQDFVDI
D
L
D
D
V
M
L
H
SEV
N
-
-
-
LPIDF
L
V
--
NQT
----
--
--
--
--
--
LT
L
G
T
EWNQQ
R
M
KDLSS
N
TQA
L
TGA
N
T
---
GGA
I
--
D
G
V
S
A
TD
------------------
R
S
P
Y
SK
AE
I
F
S
L
F
A
EN
N
ME
LTD
S
T
I
V
T
P
GLRFD
H
H
SIVGN
N
WS
PALNISQGL
GD
D
-
---F
T
LKM
G
I
A
RA
----------------
Y
KA
P
S
LY
Q
TN
P
N
--
-
YI
L
Y
S
----
-
K
G
Q
G
CY
A
--
S
AG
GCYLQGND
D
L
KAE
T
SIN
K
EIG
L
EFK
RD
G
-
-
W
L
AG
V
T
W
FR
N
D
YR
NKIE
A
G
Y
V
AV
G
QN
AV
GT
DLYQ
W
D
N
V
P
KA
V
VEG
L
E
G
S
LN---V
P
-
VSE
TVM
W
TN
N
I
T
Y
MLK
S
E
N
K
T
T
----
-
-
-----
GDRL
S
II
PEY
TLN
S
TLSW
QA
RE
D
L
S
M
Q
TTF
T
W
YG
KQQ
P
KKY
-
N
Y
KG
QPAVG
P
ETKEIS
P
-
Y
SIV
G
L
S
AT
W
D
VTKN
V
S
LTGG
VDNLFD
K
R
L
WRAGNA
Q
T
T
G
DLA
GANY
I
A
GA
G
AYT
Y
N
-
E
PG
--
RT
WY
M
SV
NTHF
fig|749545.3.peg.4920
Escherichia coli MS 182-1
MNKKIHSL
A
LLVNL
G
IYGVA
--
-
Q
A
Q
EP
TD
TPVSH
DDT
I
VVTA
-
A
E
Q
N
L
-
Q
AP
GV
S
---
-------------
T
I
T
A
DEIR
K
N
P
V
A
R
DVS
E
II
R
T
MPGVN
L
---
--
TGNST
S
G
Q
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
K
P
VS
S
R
NSV
RQGW
RGE
RDT
RG
DTSWVPPEM
I
E
R
I
EVLRGP
A
AA
R
YG
N
G
A
A
GG
V
V
NIITK
KG
SGEWH
G
SW
D
A
Y
F
NA
PE
H
KEEGATK
R
TN
FSLTGP
L
-
GD
EFSF
RLYG
NLD
--
KT
Q
A
D
AWD
IN
Q
--
G
HQSAR
AGTYATTLP
AGR
EG
V
I
N
K
DINGV
VR
WDF
AP
LQ
S
LELEA
G
YSRQGN
L
-
Y
AGD
TQ
NTNS
D
---------------
AY
T
RS
--
KY
G
D
-
E
T
NRL
Y
RQ
NY
A
LTWN
GG
WD
N
G
V
T
T
S
NWVQY
EH
-----------
TR
N
SR
IP
E
-
----
G
LA
G
-----
G
TEGKFNEK
A
TQDFVDI
D
L
D
D
V
M
L
H
SEV
N
-
-
-
LPIDF
L
V
--
NQT
----
--
--
--
--
--
LT
L
G
T
EWNQQ
R
M
KDLSS
N
TQA
L
TGA
N
T
---
GGA
I
--
D
G
V
S
A
TD
------------------
R
S
P
Y
SK
AE
I
F
S
L
F
A
EN
N
ME
LTD
S
T
I
V
T
P
GLRFD
H
H
SIVGN
N
WS
PALNISQGL
GD
D
-
---F
T
LKM
G
I
A
RA
----------------
Y
KA
P
S
LY
Q
TN
P
N
--
-
YI
L
Y
S
----
-
K
G
Q
G
CY
A
--
S
AG
GCYLQGND
D
L
KAE
T
SIN
K
EIG
L
EFK
RD
G
-
-
W
L
AG
V
T
W
FR
N
D
YR
NKIE
A
G
Y
V
AV
G
QN
AV
GT
DLYQ
W
D
N
V
P
KA
V
VEG
L
E
G
S
LN---V
P
-
VSE
TVM
W
TN
N
I
T
Y
MLK
S
E
N
K
T
T
----
-
-
-----
GDRL
S
II
PEY
TLN
S
TLSW
QA
RE
D
L
S
M
Q
TTF
T
W
YG
KQQ
P
KKY
-
N
Y
KG
QPAVG
P
ETKEIS
P
-
Y
SIV
G
L
S
AT
W
D
VTKN
V
S
LTGG
VDNLFD
K
R
L
WRAGNA
Q
T
T
G
DLA
GANY
I
A
GA
G
AYT
Y
N
-
E
PG
--
RT
WY
M
SV
NTHF
fig|749532.3.peg.3655
Escherichia coli MS 78-1
MNKKIHSL
A
LLVNL
G
IYGVA
--
-
Q
A
Q
EP
TD
TPVSH
DDT
I
VVTA
-
A
E
Q
N
L
-
Q
AP
GV
S
---
-------------
T
I
T
A
DEIR
K
N
P
V
A
R
DVS
E
II
R
T
MPGVN
L
---
--
TGNST
S
G
Q
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
K
P
VS
S
R
NSV
RQGW
RGE
RDT
RG
DTSWVPPEM
I
E
R
I
EVLRGP
A
AA
R
YG
N
G
A
A
GG
V
V
NIITK
KG
SGEWH
G
SW
D
A
Y
F
NA
PE
H
KEEGATK
R
TN
FSLTGP
L
-
GD
EFSF
RLYG
NLD
--
KT
Q
A
D
AWD
IN
Q
--
G
HQSAR
AGTYATTLP
AGR
EG
V
I
N
K
DINGV
VR
WDF
AP
LQ
S
LELEA
G
YSRQGN
L
-
Y
AGD
TQ
NTNS
D
---------------
AY
T
RS
--
KY
G
D
-
E
T
NRL
Y
RQ
NY
A
LTWN
GG
WD
N
G
V
T
T
S
NWVQY
EH
-----------
TR
N
SR
IP
E
-
----
G
LA
G
-----
G
TEGKFNEK
A
TQDFVDI
D
L
D
D
V
M
L
H
SEV
N
-
-
-
LPIDF
L
V
--
NQT
----
--
--
--
--
--
LT
L
G
T
EWNQQ
R
M
KDLSS
N
TQA
L
TGA
N
T
---
GGA
I
--
D
G
V
S
A
TD
------------------
R
S
P
Y
SK
AE
I
F
S
L
F
A
EN
N
ME
LTD
S
T
I
V
T
P
GLRFD
H
H
SIVGN
N
WS
PALNISQGL
GD
D
-
---F
T
LKM
G
I
A
RA
----------------
Y
KA
P
S
LY
Q
TN
P
N
--
-
YI
L
Y
S
----
-
K
G
Q
G
CY
A
--
S
AG
GCYLQGND
D
L
KAE
T
SIN
K
EIG
L
EFK
RD
G
-
-
W
L
AG
V
T
W
FR
N
D
YR
NKIE
A
G
Y
V
AV
G
QN
AV
GT
DLYQ
W
D
N
V
P
KA
V
VEG
L
E
G
S
LN---V
P
-
VSE
TVM
W
TN
N
I
T
Y
MLK
S
E
N
K
T
T
----
-
-
-----
GDRL
S
II
PEY
TLN
S
TLSW
QA
RE
D
L
S
M
Q
TTF
T
W
YG
KQQ
P
KKY
-
N
Y
KG
QPAVG
P
ETKEIS
P
-
Y
SIV
G
L
S
AT
W
D
VTKN
V
S
LTGG
VDNLFD
K
R
L
WRAGNA
Q
T
T
G
DLA
GANY
I
A
GA
G
AYT
Y
N
-
E
PG
--
RT
WY
M
SV
NTHF
fig|585396.4.peg.635
Escherichia coli O111:H- str. 11128
MNKKIHSL
A
LLVNL
G
IYGVA
--
-
Q
A
Q
EP
TD
TPVSH
DDT
I
VVTA
-
A
E
Q
N
L
-
Q
AP
GV
S
---
-------------
T
I
T
A
DEIR
K
N
P
V
A
R
DVS
E
II
R
T
MPGVN
L
---
--
TGNST
S
G
Q
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
K
P
VS
S
R
NSV
RQGW
RGE
RDT
RG
DTSWVPPEM
I
E
R
I
EVLRGP
A
AA
R
YG
N
G
A
A
GG
V
V
NIITK
KG
SGEWH
G
SW
D
A
Y
F
NA
PE
H
KEEGATK
R
TN
FSLTGP
L
-
GD
EFSF
RLYG
NLD
--
KT
Q
A
D
AWD
IN
Q
--
G
HQSAR
AGTYATTLP
AGR
EG
V
I
N
K
DINGV
VR
WDF
AP
LQ
S
LELEA
G
YSRQGN
L
-
Y
AGD
TQ
NTNS
D
---------------
AY
T
RS
--
KY
G
D
-
E
T
NRL
Y
RQ
NY
A
LTWN
GG
WD
N
G
V
T
T
S
NWVQY
EH
-----------
TR
N
SR
IP
E
-
----
G
LA
G
-----
G
TEGKFNEK
A
TQDFVDI
D
L
D
D
V
M
L
H
SEV
N
-
-
-
LPIDF
L
V
--
NQT
----
--
--
--
--
--
LT
L
G
T
EWNQQ
R
M
KDLSS
N
TQA
L
TGA
N
T
---
GGA
I
--
D
G
V
S
A
TD
------------------
R
S
P
Y
SK
AE
I
F
S
L
F
A
EN
N
ME
LTD
S
T
I
V
T
P
GLRFD
H
H
SIVGN
N
WS
PALNISQGL
GD
D
-
---F
T
LKM
G
I
A
RA
----------------
Y
KA
P
S
LY
Q
TN
P
N
--
-
YI
L
Y
S
----
-
K
G
Q
G
CY
A
--
S
AG
GCYLQGND
D
L
KAE
T
SIN
K
EIG
L
EFK
RD
G
-
-
W
L
AG
V
T
W
FR
N
D
YR
NKIE
A
G
Y
V
AV
G
QN
AV
GT
DLYQ
W
D
N
V
P
KA
V
VEG
L
E
G
S
LN---V
P
-
VSE
TVM
W
TN
N
I
T
Y
MLK
S
E
N
K
T
T
----
-
-
-----
GDRL
S
II
PEY
TLN
S
TLSW
QA
RE
D
L
S
M
Q
TTF
T
W
YG
KQQ
P
KKY
-
N
Y
KG
QPAVG
P
ETKEIS
P
-
Y
SIV
G
L
S
AT
W
D
VTKN
V
S
LTGG
VDNLFD
K
R
L
WRAGNA
Q
T
T
G
DLA
GANY
I
A
GA
G
AYT
Y
N
-
E
PG
--
RT
WY
M
SV
NTHF
fig|656443.3.peg.838
Escherichia coli TA271
MNKKIHSL
A
LLVNL
G
IYGVA
--
-
Q
A
Q
EP
TD
TPVSH
DDT
I
VVTA
-
A
E
Q
N
L
-
Q
AP
GV
S
---
-------------
T
I
T
A
DEIR
K
N
P
V
A
R
DVS
E
II
R
T
MPGVN
L
---
--
TGNST
S
G
Q
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
K
P
VS
S
R
NSV
RQGW
RGE
RDT
RG
DTSWVPPEM
I
E
R
I
EVLRGP
A
AA
R
YG
N
G
A
A
GG
V
V
NIITK
KG
SGEWH
G
SW
D
A
Y
F
NA
PE
H
KEEGATK
R
TN
FSLTGP
L
-
GD
EFSF
RLYG
NLD
--
KT
Q
A
D
AWD
IN
Q
--
G
HQSAR
AGTYATTLP
AGR
EG
V
I
N
K
DINGV
VR
WDF
AP
LQ
S
LELEA
G
YSRQGN
L
-
Y
AGD
TQ
NTNS
D
---------------
AY
T
RS
--
KY
G
D
-
E
T
NRL
Y
RQ
NY
A
LTWN
GG
WD
N
G
V
T
T
S
NWVQY
EH
-----------
TR
N
SR
IP
E
-
----
G
LA
G
-----
G
TEGKFNEK
A
TQDFVDI
D
L
D
D
V
M
L
H
SEV
N
-
-
-
LPIDF
L
V
--
NQT
----
--
--
--
--
--
LT
L
G
T
EWNQQ
R
M
KDLSS
N
TQA
L
TGA
N
T
---
GGA
I
--
D
G
V
S
A
TD
------------------
R
S
P
Y
SK
AE
I
F
S
L
F
A
EN
N
ME
LTD
S
T
I
V
T
P
GLRFD
H
H
SIVGN
N
WS
PALNISQGL
GD
D
-
---F
T
LKM
G
I
A
RA
----------------
Y
KA
P
S
LY
Q
TN
P
N
--
-
YI
L
Y
S
----
-
K
G
Q
G
CY
A
--
S
AG
GCYLQGND
D
L
KAE
T
SIN
K
EIG
L
EFK
RD
G
-
-
W
L
AG
V
T
W
FR
N
D
YR
NKIE
A
G
Y
V
AV
G
QN
AV
GT
DLYQ
W
D
N
V
P
KA
V
VEG
L
E
G
S
LN---V
P
-
VSE
TVM
W
TN
N
I
T
Y
MLK
S
E
N
K
T
T
----
-
-
-----
GDRL
S
II
PEY
TLN
S
TLSW
QA
RE
D
L
S
M
Q
TTF
T
W
YG
KQQ
P
KKY
-
N
Y
KG
QPAVG
P
ETKEIS
P
-
Y
SIV
G
L
S
AT
W
D
VTKN
V
S
LTGG
VDNLFD
K
R
L
WRAGNA
Q
T
T
G
DLA
GANY
I
A
GA
G
AYT
Y
N
-
E
PG
--
RT
WY
M
SV
NTHF
fig|566546.3.peg.2868
Escherichia coli W
MNKKIHSL
A
LLVNL
G
IYGVA
--
-
Q
A
Q
EP
TD
TPVSH
DDT
I
VVTA
-
A
E
Q
N
L
-
Q
AP
GV
S
---
-------------
T
I
T
A
DEIR
K
N
P
V
A
R
DVS
E
II
R
T
MPGVN
L
---
--
TGNST
S
G
Q
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
K
P
VS
S
R
NSV
RQGW
RGE
RDT
RG
DTSWVPPEM
I
E
R
I
EVLRGP
A
AA
R
YG
N
G
A
A
GG
V
V
NIITK
KG
SGEWH
G
SW
D
A
Y
F
NA
PE
H
KEEGATK
R
TN
FSLTGP
L
-
GD
EFSF
RLYG
NLD
--
KT
Q
A
D
AWD
IN
Q
--
G
HQSAR
AGTYATTLP
AGR
EG
V
I
N
K
DINGV
VR
WDF
AP
LQ
S
LELEA
G
YSRQGN
L
-
Y
AGD
TQ
NTNS
D
---------------
AY
T
RS
--
KY
G
D
-
E
T
NRL
Y
RQ
NY
A
LTWN
GG
WD
N
G
V
T
T
S
NWVQY
EH
-----------
TR
N
SR
IP
E
-
----
G
LA
G
-----
G
TEGKFNEK
A
TQDFVDI
D
L
D
D
V
M
L
H
SEV
N
-
-
-
LPIDF
L
V
--
NQT
----
--
--
--
--
--
LT
L
G
T
EWNQQ
R
M
KDLSS
N
TQA
L
TGA
N
T
---
GGA
I
--
D
G
V
S
A
TD
------------------
R
S
P
Y
SK
AE
I
F
S
L
F
A
EN
N
ME
LTD
S
T
I
V
T
P
GLRFD
H
H
SIVGN
N
WS
PALNISQGL
GD
D
-
---F
T
LKM
G
I
A
RA
----------------
Y
KA
P
S
LY
Q
TN
P
N
--
-
YI
L
Y
S
----
-
K
G
Q
G
CY
A
--
S
AG
GCYLQGND
D
L
KAE
T
SIN
K
EIG
L
EFK
RD
G
-
-
W
L
AG
V
T
W
FR
N
D
YR
NKIE
A
G
Y
V
AV
G
QN
AV
GT
DLYQ
W
D
N
V
P
KA
V
VEG
L
E
G
S
LN---V
P
-
VSE
TVM
W
TN
N
I
T
Y
MLK
S
E
N
K
T
T
----
-
-
-----
GDRL
S
II
PEY
TLN
S
TLSW
QA
RE
D
L
S
M
Q
TTF
T
W
YG
KQQ
P
KKY
-
N
Y
KG
QPAVG
P
ETKEIS
P
-
Y
SIV
G
L
S
AT
W
D
VTKN
V
S
LTGG
VDNLFD
K
R
L
WRAGNA
Q
T
T
G
DLA
GANY
I
A
GA
G
AYT
Y
N
-
E
PG
--
RT
WY
M
SV
NTHF
fig|566546.4.peg.641
Escherichia coli W
MNKKIHSL
A
LLVNL
G
IYGVA
--
-
Q
A
Q
EP
TD
TPVSH
DDT
I
VVTA
-
A
E
Q
N
L
-
Q
AP
GV
S
---
-------------
T
I
T
A
DEIR
K
N
P
V
A
R
DVS
E
II
R
T
MPGVN
L
---
--
TGNST
S
G
Q
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
K
P
VS
S
R
NSV
RQGW
RGE
RDT
RG
DTSWVPPEM
I
E
R
I
EVLRGP
A
AA
R
YG
N
G
A
A
GG
V
V
NIITK
KG
SGEWH
G
SW
D
A
Y
F
NA
PE
H
KEEGATK
R
TN
FSLTGP
L
-
GD
EFSF
RLYG
NLD
--
KT
Q
A
D
AWD
IN
Q
--
G
HQSAR
AGTYATTLP
AGR
EG
V
I
N
K
DINGV
VR
WDF
AP
LQ
S
LELEA
G
YSRQGN
L
-
Y
AGD
TQ
NTNS
D
---------------
AY
T
RS
--
KY
G
D
-
E
T
NRL
Y
RQ
NY
A
LTWN
GG
WD
N
G
V
T
T
S
NWVQY
EH
-----------
TR
N
SR
IP
E
-
----
G
LA
G
-----
G
TEGKFNEK
A
TQDFVDI
D
L
D
D
V
M
L
H
SEV
N
-
-
-
LPIDF
L
V
--
NQT
----
--
--
--
--
--
LT
L
G
T
EWNQQ
R
M
KDLSS
N
TQA
L
TGA
N
T
---
GGA
I
--
D
G
V
S
A
TD
------------------
R
S
P
Y
SK
AE
I
F
S
L
F
A
EN
N
ME
LTD
S
T
I
V
T
P
GLRFD
H
H
SIVGN
N
WS
PALNISQGL
GD
D
-
---F
T
LKM
G
I
A
RA
----------------
Y
KA
P
S
LY
Q
TN
P
N
--
-
YI
L
Y
S
----
-
K
G
Q
G
CY
A
--
S
AG
GCYLQGND
D
L
KAE
T
SIN
K
EIG
L
EFK
RD
G
-
-
W
L
AG
V
T
W
FR
N
D
YR
NKIE
A
G
Y
V
AV
G
QN
AV
GT
DLYQ
W
D
N
V
P
KA
V
VEG
L
E
G
S
LN---V
P
-
VSE
TVM
W
TN
N
I
T
Y
MLK
S
E
N
K
T
T
----
-
-
-----
GDRL
S
II
PEY
TLN
S
TLSW
QA
RE
D
L
S
M
Q
TTF
T
W
YG
KQQ
P
KKY
-
N
Y
KG
QPAVG
P
ETKEIS
P
-
Y
SIV
G
L
S
AT
W
D
VTKN
V
S
LTGG
VDNLFD
K
R
L
WRAGNA
Q
T
T
G
DLA
GANY
I
A
GA
G
AYT
Y
N
-
E
PG
--
RT
WY
M
SV
NTHF
fig|679207.4.peg.2879
Escherichia coli MS 107-1
MNKKIHSL
A
LLVNL
G
IYGVA
--
-
Q
A
Q
EP
TD
TPVSH
DDT
I
VVTA
-
A
E
Q
N
L
-
Q
AP
GV
S
---
-------------
T
I
T
A
DEIR
K
N
P
V
A
R
DVS
E
II
R
T
MPGVN
L
---
--
TGNST
S
G
Q
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
K
P
VS
S
R
NSV
RQGW
RGE
RDT
RG
DTSWVPPEM
I
E
R
I
EVLRGP
A
AA
R
YG
N
G
A
A
GG
V
V
NIITK
KG
SGEWH
G
SW
D
A
Y
F
NA
PE
H
KEEGATK
R
TN
FSLTGP
L
-
GD
EFSF
H
LYG
NLD
--
KT
Q
A
D
AWD
IN
Q
--
G
HQSAR
AGTYATTLP
AGR
EG
V
I
N
K
DINGV
VR
WDF
AP
LQ
S
LELEA
G
YSRQGN
L
-
Y
AGD
TQ
NTNS
D
---------------
AY
T
RS
--
KY
G
D
-
E
T
NRL
Y
RQ
NY
A
LTWN
GG
WD
N
G
V
T
T
S
NWVQY
EH
-----------
TR
N
SR
IP
E
-
----
G
LA
G
-----
G
TEGKFNEK
A
TQDFVDI
D
L
D
D
V
M
L
H
SEV
N
-
-
-
LPIDF
L
V
--
NQT
----
--
--
--
--
--
LT
L
G
T
EWNQQ
R
M
KDLSS
N
TQA
L
TGA
N
T
---
GGA
I
--
D
G
V
S
A
TD
------------------
R
S
P
Y
SK
AE
I
F
S
L
F
A
EN
N
ME
LTD
S
T
I
V
T
P
GLRFD
H
H
SIVGN
N
WS
PALNISQGL
GD
D
-
---F
T
LKM
G
I
A
RA
----------------
Y
KA
P
S
LY
Q
TN
P
N
--
-
YI
L
Y
S
----
-
K
G
Q
G
CY
A
--
S
AG
GCYLQGND
D
L
KAE
T
SIN
K
EIG
L
EFK
RD
G
-
-
W
L
AG
V
T
W
FR
N
D
YR
NKIE
A
G
Y
V
AV
G
QN
AV
GT
DLYQ
W
D
N
V
P
KA
V
VEG
L
E
G
S
LN---V
P
-
VSE
TVM
W
TN
N
I
T
Y
MLK
S
E
N
K
T
T
----
-
-
-----
GDRL
S
II
PEY
TLN
S
TLSW
QA
RE
D
L
S
M
Q
TTF
T
W
YG
KQQ
P
KKY
-
N
Y
KG
QPAVG
P
ETKEIS
P
-
Y
SIV
G
L
S
AT
W
D
VTKN
V
S
LTGG
VDNLFD
K
R
L
WRAGNA
Q
T
T
G
DLA
GANY
I
A
GA
G
AYT
Y
N
-
E
PG
--
RT
WY
M
SV
NTHF
fig|340185.3.peg.1754
Escherichia coli E22
MNKKIHSL
A
LLVNL
G
IYGVA
--
-
Q
A
Q
EP
TD
TPVSH
DDT
I
VVTA
-
A
E
Q
N
L
-
Q
AP
GV
S
---
-------------
T
I
T
A
DEIR
K
N
P
V
A
R
DVS
E
II
R
T
MPGVN
L
---
--
TGNST
S
G
Q
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
K
P
VS
S
R
NSV
RQGW
RGE
RDT
RG
DTSWVPPEM
I
E
R
I
EVLRGP
A
AA
R
YG
N
G
A
A
GG
V
V
NIITK
KG
SGEWH
G
SW
D
A
Y
F
NA
PE
H
KEEGATK
R
TN
FSLTGP
L
-
GD
EFSF
RLYG
NLD
--
KT
Q
A
D
AWD
IN
Q
--
G
HQSAR
AGTY
V
TTLP
AGR
EG
V
I
N
K
DINGV
VR
WDF
AP
LQ
S
LELEA
G
YSRQGN
L
-
Y
AGD
TQ
NTNS
D
---------------
AY
T
RS
--
KY
G
D
-
E
T
NRL
Y
RQ
NY
A
LTWN
GG
WD
N
G
V
T
T
S
NWVQY
EH
-----------
TR
N
SR
IP
E
-
----
G
LA
G
-----
G
TEGKFNEK
A
TQDFVDI
D
L
D
D
V
M
L
H
SEV
N
-
-
-
LPIDF
L
V
--
NQT
----
--
--
--
--
--
LT
L
G
T
EWNQQ
R
M
KDLSS
N
TQA
L
TGA
N
T
---
GGA
I
--
D
G
V
S
A
TD
------------------
R
S
P
Y
SK
AE
I
F
S
L
F
A
EN
N
ME
LTD
S
T
I
V
T
P
GLRFD
H
H
SIVGN
N
WS
PALNISQGL
GD
D
-
---F
T
LKM
G
I
A
RA
----------------
Y
KA
P
S
LY
Q
TN
P
N
--
-
YI
L
Y
S
----
-
K
G
Q
G
CY
A
--
S
AG
GCYLQGND
D
L
KAE
T
SIN
K
EIG
L
EFK
RD
G
-
-
W
L
AG
V
T
W
FR
N
D
YR
NKIE
A
G
Y
V
AV
G
QN
AV
GT
DLYQ
W
D
N
V
P
KA
V
VEG
L
E
G
S
LN---V
P
-
VSE
TVM
W
TN
N
I
T
Y
MLK
S
K
N
K
T
T
----
-
-
-----
GDRL
S
II
PEY
TLN
S
TLSW
QA
RE
D
L
S
M
Q
TTF
T
W
YG
KQQ
P
KKY
-
N
Y
KG
QPAVG
P
ETKEIS
P
-
Y
SIV
G
L
S
AT
W
D
VTKN
V
S
LTGG
VDNLFD
K
R
L
WRAGNA
Q
T
T
G
DLA
GANY
I
A
GA
G
AYT
Y
N
-
E
PG
--
RT
WY
M
SV
NTHF
fig|340185.4.peg.1848
Escherichia coli E22
MNKKIHSL
A
LLVNL
G
IYGVA
--
-
Q
A
Q
EP
TD
TPVSH
DDT
I
VVTA
-
A
E
Q
N
L
-
Q
AP
GV
S
---
-------------
T
I
T
A
DEIR
K
N
P
V
A
R
DVS
E
II
R
T
MPGVN
L
---
--
TGNST
S
G
Q
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
K
P
VS
S
R
NSV
RQGW
RGE
RDT
RG
DTSWVPPEM
I
E
R
I
EVLRGP
A
AA
R
YG
N
G
A
A
GG
V
V
NIITK
KG
SGEWH
G
SW
D
A
Y
F
NA
PE
H
KEEGATK
R
TN
FSLTGP
L
-
GD
EFSF
RLYG
NLD
--
KT
Q
A
D
AWD
IN
Q
--
G
HQSAR
AGTY
V
TTLP
AGR
EG
V
I
N
K
DINGV
VR
WDF
AP
LQ
S
LELEA
G
YSRQGN
L
-
Y
AGD
TQ
NTNS
D
---------------
AY
T
RS
--
KY
G
D
-
E
T
NRL
Y
RQ
NY
A
LTWN
GG
WD
N
G
V
T
T
S
NWVQY
EH
-----------
TR
N
SR
IP
E
-
----
G
LA
G
-----
G
TEGKFNEK
A
TQDFVDI
D
L
D
D
V
M
L
H
SEV
N
-
-
-
LPIDF
L
V
--
NQT
----
--
--
--
--
--
LT
L
G
T
EWNQQ
R
M
KDLSS
N
TQA
L
TGA
N
T
---
GGA
I
--
D
G
V
S
A
TD
------------------
R
S
P
Y
SK
AE
I
F
S
L
F
A
EN
N
ME
LTD
S
T
I
V
T
P
GLRFD
H
H
SIVGN
N
WS
PALNISQGL
GD
D
-
---F
T
LKM
G
I
A
RA
----------------
Y
KA
P
S
LY
Q
TN
P
N
--
-
YI
L
Y
S
----
-
K
G
Q
G
CY
A
--
S
AG
GCYLQGND
D
L
KAE
T
SIN
K
EIG
L
EFK
RD
G
-
-
W
L
AG
V
T
W
FR
N
D
YR
NKIE
A
G
Y
V
AV
G
QN
AV
GT
DLYQ
W
D
N
V
P
KA
V
VEG
L
E
G
S
LN---V
P
-
VSE
TVM
W
TN
N
I
T
Y
MLK
S
K
N
K
T
T
----
-
-
-----
GDRL
S
II
PEY
TLN
S
TLSW
QA
RE
D
L
S
M
Q
TTF
T
W
YG
KQQ
P
KKY
-
N
Y
KG
QPAVG
P
ETKEIS
P
-
Y
SIV
G
L
S
AT
W
D
VTKN
V
S
LTGG
VDNLFD
K
R
L
WRAGNA
Q
T
T
G
DLA
GANY
I
A
GA
G
AYT
Y
N
-
E
PG
--
RT
WY
M
SV
NTHF
fig|585395.4.peg.619
Escherichia coli O103:H2 str. 12009
MNKKIHSL
A
LLVNL
G
IYGVA
--
-
Q
A
Q
EP
TD
TPVSH
DDT
I
VVTA
-
A
E
Q
N
L
-
Q
AP
GV
S
---
-------------
T
I
T
A
DEIR
K
N
P
V
A
R
DVS
E
II
R
T
MPGVN
L
---
--
TGNST
S
G
Q
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
K
P
VS
S
R
NSV
RQGW
RGE
RDT
RG
DTSWVPPEM
I
E
R
I
EVLRGP
A
AA
R
YG
N
G
A
A
GG
V
V
NIITK
KG
SGEWH
G
SW
D
A
Y
F
NA
PE
H
KEEGATK
R
TN
FSLTGP
L
-
GD
EFSF
RLYG
NLD
--
KT
Q
A
D
AWD
IN
Q
--
G
HQSAR
AGTY
V
TTLP
AGR
EG
V
I
N
K
DINGV
VR
WDF
AP
LQ
S
LELEA
G
YSRQGN
L
-
Y
AGD
TQ
NTNS
D
---------------
AY
T
RS
--
KY
G
D
-
E
T
NRL
Y
RQ
NY
A
LTWN
GG
WD
N
G
V
T
T
S
NWVQY
EH
-----------
TR
N
SR
IP
E
-
----
G
LA
G
-----
G
TEGKFNEK
A
TQDFVDI
D
L
D
D
V
M
L
H
SEV
N
-
-
-
LPIDF
L
V
--
NQT
----
--
--
--
--
--
LT
L
G
T
EWNQQ
R
M
KDLSS
N
TQA
L
TGA
N
T
---
GGA
I
--
D
G
V
S
A
TD
------------------
R
S
P
Y
SK
AE
I
F
S
L
F
A
EN
N
ME
LTD
S
T
I
V
T
P
GLRFD
H
H
SIVGN
N
WS
PALNISQGL
GD
D
-
---F
T
LKM
G
I
A
RA
----------------
Y
KA
P
S
LY
Q
TN
P
N
--
-
YI
L
Y
S
----
-
K
G
Q
G
CY
A
--
S
AG
GCYLQGND
D
L
KAE
T
SIN
K
EIG
L
EFK
RD
G
-
-
W
L
AG
V
T
W
FR
N
D
YR
NKIE
A
G
Y
V
AV
G
QN
AV
GT
DLYQ
W
D
N
V
P
KA
V
VEG
L
E
G
S
LN---V
P
-
VSE
TVM
W
TN
N
I
T
Y
MLK
S
K
N
K
T
T
----
-
-
-----
GDRL
S
II
PEY
TLN
S
TLSW
QA
RE
D
L
S
M
Q
TTF
T
W
YG
KQQ
P
KKY
-
N
Y
KG
QPAVG
P
ETKEIS
P
-
Y
SIV
G
L
S
AT
W
D
VTKN
V
S
LTGG
VDNLFD
K
R
L
WRAGNA
Q
T
T
G
DLA
GANY
I
A
GA
G
AYT
Y
N
-
E
PG
--
RT
WY
M
SV
NTHF
fig|679204.3.peg.2684
Escherichia coli MS 145-7
MNKKIHSL
A
LLVNL
G
IYGVA
--
-
Q
A
Q
EP
TD
TPVSH
DDT
I
VVTA
-
A
E
Q
N
L
-
Q
AP
GV
S
---
-------------
T
I
T
A
DEIR
K
N
P
V
A
R
DVS
E
II
R
T
MPGVN
L
---
--
TGNST
S
G
Q
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
K
P
VS
S
R
NSV
RQGW
RGE
RDT
RG
DTSWVPPEM
I
E
R
I
EVLRGP
A
AA
R
YG
N
G
A
A
GG
V
V
NIIT
QKG
SGEWH
G
SW
D
A
Y
F
NA
PE
H
KEEGATK
R
TN
FSLTGP
L
-
GD
EFSF
RLYG
NLD
--
KT
Q
A
D
AWD
IN
Q
--
G
HQSAR
AGTYATTLP
AGR
EG
V
I
N
K
DINGV
VR
WDF
AP
LQ
S
LELEA
G
YSRQGN
L
-
Y
AGD
TQ
NTNS
D
---------------
AY
T
RS
--
KY
G
D
-
E
T
NRL
Y
RQ
NY
A
LTWN
GG
WD
N
G
V
T
T
S
NWVQY
EH
-----------
TR
N
SR
IP
E
-
----
G
LA
G
-----
G
TEGKFNEK
A
TQDFVDI
D
L
D
D
V
M
L
H
SEV
N
-
-
-
LPIDF
L
V
--
NQT
----
--
--
--
--
--
LT
L
G
T
EWNQQ
R
M
KDLSS
N
TQA
L
TGA
N
T
---
GGA
I
--
D
G
V
S
A
TD
------------------
R
S
P
Y
SK
AE
I
F
S
L
F
A
EN
N
ME
LTD
S
T
I
V
T
P
GLRFD
H
H
SIVGN
N
WS
PALNISQGL
GD
D
-
---F
T
LKM
G
I
A
RA
----------------
Y
KA
P
S
LY
Q
TN
P
N
--
-
YI
L
Y
S
----
-
K
G
Q
G
CY
A
--
S
AG
GCYLQGND
D
L
KAE
T
SIN
K
EIG
L
EFK
RD
G
-
-
W
L
AG
V
T
W
FR
N
D
YR
NKIE
A
G
Y
V
AV
G
QN
AV
GT
DLYQ
W
D
N
V
P
KA
V
VEG
L
E
G
S
LN---V
P
-
VSE
TVM
W
TN
N
I
T
Y
MLK
S
E
N
K
T
T
----
-
-
-----
GDRL
S
II
PEY
TLN
S
TLSW
QA
RE
D
L
S
M
Q
TTF
T
W
YG
KQQ
P
KKY
-
N
Y
KG
QPAVG
P
ETKEIS
P
-
Y
SIV
G
L
S
AT
W
D
VTKN
V
S
LTGG
VDNLFD
K
R
L
WRAGNA
Q
T
T
G
DLA
GANY
I
A
GA
G
AYT
Y
N
-
E
PG
--
RT
WY
M
SV
NTHF
fig|656408.3.peg.516
Escherichia coli H591
MNKKIHSL
A
LLVNL
G
IYGVA
--
-
Q
A
Q
EP
TD
TPVSH
DDT
I
VVTA
-
A
E
Q
N
L
-
Q
AP
GV
S
---
-------------
T
I
T
A
DEIR
K
N
P
V
A
R
DVS
E
II
R
T
MPGVN
L
---
--
TGNST
S
G
Q
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
K
P
VS
S
R
NSV
RQGW
RGE
RDT
RG
DTSWVPPEM
I
E
R
I
EVLRGP
A
AA
R
YG
N
G
A
A
GG
V
V
NIITK
KG
SGEWH
G
SW
D
A
Y
F
NA
PE
H
KEEGATK
R
TN
FSLTGP
L
-
GD
EFSF
RLYG
NLD
--
KT
Q
A
D
AWD
IN
Q
--
G
HQSAR
AGTYATTLP
AGR
EG
V
I
N
K
DINGV
VR
WDF
AP
LQ
S
LELEA
G
YSRQGN
L
-
Y
AGD
TQ
NTNS
D
---------------
AY
T
RS
--
KY
G
D
-
E
T
NRL
Y
RQ
NY
A
LTWN
GG
WD
N
G
V
T
T
S
NWVQY
EH
-----------
TR
N
SR
IP
E
-
----
G
LA
G
-----
G
TEGKFNEK
A
TQDFVDI
D
L
D
D
V
M
L
H
SEV
N
-
-
-
LPIDF
L
V
--
NQT
----
--
--
--
--
--
LT
L
G
T
EWNQQ
R
M
KDLSS
N
TQA
L
TGA
N
T
---
GGA
I
--
D
G
V
S
A
TD
------------------
R
S
P
Y
SK
AE
I
F
S
L
F
A
EN
N
ME
LTD
S
T
I
V
T
P
GLRFD
H
H
SIVGN
N
WS
PALNISQGL
GD
D
-
---L
T
LKM
G
I
A
RA
----------------
Y
KA
P
S
LY
Q
TN
P
N
--
-
YI
L
Y
S
----
-
K
G
Q
G
CY
A
--
S
AG
GCYLQGND
D
L
KAE
T
SIN
K
EIG
L
EFK
RD
G
-
-
W
L
AG
V
T
W
FR
N
D
YR
NKIE
A
G
Y
V
AV
G
QN
AV
GT
DLYQ
W
D
N
V
P
KA
V
VEG
L
E
G
S
LN---V
P
-
VSE
TVM
W
TN
N
I
T
Y
MLK
S
E
N
K
T
T
----
-
-
-----
GDRL
S
II
PEY
TLN
S
TLSW
QA
RE
D
L
S
M
Q
TTF
T
W
YG
KQQ
P
KKY
-
N
Y
KG
QPAVG
P
ETKEIS
P
-
Y
SIV
G
L
S
AT
W
D
VTKN
V
S
LTGG
VDNLFD
K
R
L
WRAGNA
Q
T
T
G
DLA
GANY
I
A
GA
G
AYT
Y
N
-
E
PG
--
RT
WY
M
SV
NTHF
fig|344601.3.peg.2287
Escherichia coli B171
MNKKIHSL
A
LLVNL
G
IYGVA
--
-
Q
A
Q
EP
TD
TPVSH
DDT
I
VVTA
-
A
E
Q
N
L
-
Q
AP
GV
S
---
-------------
T
I
T
A
DEIR
K
N
P
V
A
R
DVS
E
II
R
T
MPGVN
L
---
--
TGNST
S
G
Q
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
K
P
VS
S
R
NSV
RQGW
RGE
RDT
RG
DTSWVPPEM
I
E
R
I
EVLRGP
A
AA
R
YG
N
G
A
A
GG
V
V
NIITK
KG
SGEWH
G
SW
D
A
Y
F
NA
PE
H
KEEGATK
R
TN
FSLTGP
L
-
GD
EFSF
RLYG
NLD
--
KT
Q
A
D
AWD
IN
Q
--
G
HQSAR
AGTY
V
TTLP
AGR
EG
V
I
N
K
DINGV
VR
WDF
AP
LQ
S
LELEA
G
YSRQGN
L
-
Y
AGD
TQ
NTNS
D
---------------
AY
T
RS
--
KY
G
D
-
E
T
NRL
Y
RQ
NY
A
LTWN
GG
WD
N
G
V
T
T
S
NWVQY
EH
-----------
TR
N
SR
IP
E
-
----
G
LA
G
-----
G
TEGKFNEK
A
TQDFVDI
D
L
D
D
V
M
L
H
SEV
N
-
-
-
LPIDF
L
V
--
NQT
----
--
--
--
--
--
LT
L
G
T
EWNQQ
R
M
KDLSS
N
TQA
L
TGA
N
T
---
GGA
I
--
D
G
V
S
A
TD
------------------
R
S
P
Y
SK
AE
I
F
S
L
F
A
EN
N
ME
LTD
S
T
I
V
T
P
GLRFD
H
H
SIVGN
N
WS
PALNISQGL
GD
D
-
---F
T
LKM
G
I
A
RA
----------------
Y
KA
P
S
LY
Q
TN
P
N
--
-
YI
L
Y
S
----
-
K
G
Q
G
CY
A
--
S
AG
GCYLQGND
D
L
KAE
T
SIN
K
EIG
L
EFK
RD
G
-
-
W
L
AG
V
T
W
FR
N
D
YR
NKIE
A
G
Y
V
AV
G
QN
AV
GT
DLYQ
W
D
N
V
P
KA
V
VEG
L
E
G
S
LN---V
P
-
VSE
TVM
W
TN
N
I
T
Y
MLK
S
E
N
K
T
T
----
-
-
-----
GDRL
S
II
PEY
TLN
S
TLSW
QA
RE
D
L
S
M
Q
TTF
T
W
YG
KQQ
P
KKY
-
N
Y
KG
QPAVG
P
ETKEIS
P
-
Y
SIV
G
L
S
AT
W
D
VTKN
V
S
LTGG
VDNLFD
K
R
L
WRAGNA
Q
T
T
G
DLA
R
ANY
I
A
GA
G
AYT
Y
N
-
E
PG
--
RT
WY
M
SV
NTHF
fig|344601.5.peg.2388
Escherichia coli B171
MNKKIHSL
A
LLVNL
G
IYGVA
--
-
Q
A
Q
EP
TD
TPVSH
DDT
I
VVTA
-
A
E
Q
N
L
-
Q
AP
GV
S
---
-------------
T
I
T
A
DEIR
K
N
P
V
A
R
DVS
E
II
R
T
MPGVN
L
---
--
TGNST
S
G
Q
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
K
P
VS
S
R
NSV
RQGW
RGE
RDT
RG
DTSWVPPEM
I
E
R
I
EVLRGP
A
AA
R
YG
N
G
A
A
GG
V
V
NIITK
KG
SGEWH
G
SW
D
A
Y
F
NA
PE
H
KEEGATK
R
TN
FSLTGP
L
-
GD
EFSF
RLYG
NLD
--
KT
Q
A
D
AWD
IN
Q
--
G
HQSAR
AGTY
V
TTLP
AGR
EG
V
I
N
K
DINGV
VR
WDF
AP
LQ
S
LELEA
G
YSRQGN
L
-
Y
AGD
TQ
NTNS
D
---------------
AY
T
RS
--
KY
G
D
-
E
T
NRL
Y
RQ
NY
A
LTWN
GG
WD
N
G
V
T
T
S
NWVQY
EH
-----------
TR
N
SR
IP
E
-
----
G
LA
G
-----
G
TEGKFNEK
A
TQDFVDI
D
L
D
D
V
M
L
H
SEV
N
-
-
-
LPIDF
L
V
--
NQT
----
--
--
--
--
--
LT
L
G
T
EWNQQ
R
M
KDLSS
N
TQA
L
TGA
N
T
---
GGA
I
--
D
G
V
S
A
TD
------------------
R
S
P
Y
SK
AE
I
F
S
L
F
A
EN
N
ME
LTD
S
T
I
V
T
P
GLRFD
H
H
SIVGN
N
WS
PALNISQGL
GD
D
-
---F
T
LKM
G
I
A
RA
----------------
Y
KA
P
S
LY
Q
TN
P
N
--
-
YI
L
Y
S
----
-
K
G
Q
G
CY
A
--
S
AG
GCYLQGND
D
L
KAE
T
SIN
K
EIG
L
EFK
RD
G
-
-
W
L
AG
V
T
W
FR
N
D
YR
NKIE
A
G
Y
V
AV
G
QN
AV
GT
DLYQ
W
D
N
V
P
KA
V
VEG
L
E
G
S
LN---V
P
-
VSE
TVM
W
TN
N
I
T
Y
MLK
S
E
N
K
T
T
----
-
-
-----
GDRL
S
II
PEY
TLN
S
TLSW
QA
RE
D
L
S
M
Q
TTF
T
W
YG
KQQ
P
KKY
-
N
Y
KG
QPAVG
P
ETKEIS
P
-
Y
SIV
G
L
S
AT
W
D
VTKN
V
S
LTGG
VDNLFD
K
R
L
WRAGNA
Q
T
T
G
DLA
R
ANY
I
A
GA
G
AYT
Y
N
-
E
PG
--
RT
WY
M
SV
NTHF
fig|573235.3.peg.664
Escherichia coli O26:H11 str. 11368
MNKKIHSL
A
LLVNL
G
IYGVA
--
-
Q
A
Q
EP
TD
TPVSH
DDT
I
VVTA
-
A
E
Q
N
L
-
Q
AP
GV
S
---
-------------
T
I
T
A
DEIR
K
N
P
V
A
R
DVS
E
II
R
T
MPGVN
L
---
--
TGNST
S
G
Q
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
K
P
VS
S
R
NSV
RQGW
RGE
RDT
RG
DTSWVPPEM
I
E
R
I
EVLRGP
A
AA
R
YG
N
G
A
A
GG
V
V
NIITK
KG
SGEWH
G
SW
D
A
Y
F
NA
PE
H
KEEGATK
R
TN
FSLTGP
L
-
GD
EFSF
RLYG
NLD
--
KT
Q
A
D
AWD
IN
Q
--
G
HQSAR
AGTYATTLP
AGR
EG
V
I
N
K
DINGV
VR
WDF
AP
LQ
S
LELEA
G
YSRQGN
L
-
Y
AGD
TQ
NTNS
D
---------------
AY
T
RS
--
KY
G
D
-
E
T
NRL
Y
RQ
NY
A
LTWN
GG
WD
N
G
V
T
T
S
NWVQY
EH
-----------
TR
N
SR
IP
E
-
----
G
LA
G
-----
G
TEGKFNEK
A
TQDFVDI
D
L
D
D
V
M
L
H
SEV
N
-
-
-
LPIDI
L
V
--
NQT
----
--
--
--
--
--
LT
L
G
T
EWNQQ
R
M
KDLSS
N
TQA
L
TGA
N
T
---
GGA
I
--
D
G
M
S
A
TD
------------------
R
S
P
Y
SK
AE
I
F
S
L
F
A
EN
N
ME
LTD
S
T
I
V
T
P
GLRFD
H
H
SIVGN
N
WS
PALNISQGL
GD
D
-
---F
T
LKM
G
I
A
RA
----------------
Y
KA
P
S
LY
Q
TN
P
N
--
-
YI
L
Y
S
----
-
K
G
Q
G
CY
A
--
S
AG
GCYLQGND
D
L
KAE
T
SIN
K
EIG
L
EFK
RD
G
-
-
W
L
AG
V
T
W
FR
N
D
YR
NKIE
A
G
Y
V
AV
G
QN
AV
GT
DLYQ
W
D
N
V
P
KA
V
VEG
L
E
G
S
LN---V
P
-
VSE
TVM
W
TN
N
I
T
Y
MLK
S
E
N
K
T
T
----
-
-
-----
GDRL
S
II
PEY
TLN
S
TLSW
QA
RE
D
L
S
M
Q
TTF
T
W
YG
KQQ
P
KKY
-
N
Y
KG
QPAVG
P
ETKEIS
P
-
Y
SIV
G
L
S
AT
W
D
VTKN
V
S
LTGG
VDNLFD
K
R
L
WRAGNA
Q
T
T
G
DLA
GANY
I
A
GA
G
AYT
Y
N
-
E
PG
--
RT
WY
M
SV
NTHF
fig|670888.3.peg.1147
Escherichia coli 1827-70
MNKKIHSL
A
LLVNL
G
IYGVA
--
-
Q
A
Q
EP
TD
TPVSH
DDT
I
VVTA
-
A
E
Q
N
L
-
Q
AP
GV
S
---
-------------
T
I
T
A
DEIR
K
N
P
V
A
R
DVS
E
II
R
T
MPGVN
L
---
--
TGNST
S
G
Q
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
K
P
VS
S
R
NSV
RQGW
RGE
RDT
RG
DTSWVPPEM
I
E
R
I
EVLRGP
A
AA
R
YG
N
G
A
A
GG
V
V
NIITK
KG
SGEWH
G
SW
D
A
Y
F
NA
PE
H
KEEGATK
R
TN
FSLTGP
L
-
GD
EFSF
RLYG
NLD
--
KT
Q
A
D
AWD
IN
Q
--
G
HQSAR
AGTYATTLP
AGR
EG
V
I
N
K
DINGV
VR
WDF
AP
LQ
S
LELEA
G
YSRQGN
L
-
Y
AGD
TQ
NTNS
D
---------------
SY
T
RS
--
KY
G
D
-
E
T
NRL
Y
RQ
NY
A
LTWN
GG
WD
N
G
V
T
T
S
NWVQY
EH
-----------
TR
N
SR
IP
E
-
----
G
LA
G
-----
G
TEGKFNEK
A
TQDFVDI
D
L
D
D
V
M
L
H
SEV
N
-
-
-
LPIDF
L
V
--
NQT
----
--
--
--
--
--
LT
L
G
T
EWNQQ
R
M
KDLSS
N
TQA
L
TGT
N
T
---
GGA
I
--
D
G
V
S
A
TD
------------------
R
S
P
Y
SK
AE
I
F
S
L
F
A
EN
N
ME
LTD
S
T
I
V
T
P
GLRFD
H
H
SIVGN
N
WS
PALNISQGL
GD
D
-
---F
T
LKM
G
I
A
RA
----------------
Y
KA
P
S
LY
Q
TN
P
N
--
-
YI
L
Y
S
----
-
K
G
Q
G
CY
A
--
S
AG
GCYLQGND
D
L
KAE
T
SIN
K
EIG
L
EFK
RD
G
-
-
W
L
AG
V
T
W
FR
N
D
YR
NKIE
A
G
Y
V
AV
G
QN
AV
GT
DLYQ
W
D
N
V
P
KA
V
VEG
L
E
G
S
LN---V
P
-
VSE
TVM
W
TN
N
I
T
Y
MLK
S
E
N
K
T
T
----
-
-
-----
GDRL
S
II
PEY
TLN
S
TLSW
QA
RE
D
L
S
M
Q
TTF
T
W
YG
KQQ
P
KKY
-
N
Y
KG
QPAVG
P
ETKEIS
P
-
Y
SIV
G
L
S
AT
W
D
VTKN
V
S
LTGG
VDNLFD
K
R
L
WRAGNA
Q
T
T
G
DLA
GANY
I
A
GA
G
AYT
Y
N
-
E
PG
--
RT
WY
M
SV
NTHF
fig|481805.3.peg.3284
Escherichia coli ATCC 8739
MNKKIHSL
A
LLVNL
G
IYGVA
--
-
Q
A
Q
EP
TD
TPVSH
DDT
I
VVTA
-
A
E
Q
N
L
-
Q
AP
GV
S
---
-------------
T
I
T
A
DEIR
K
N
P
V
A
R
DVS
E
II
R
T
MPGVN
L
---
--
TGNST
S
G
Q
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
K
P
VS
S
R
NSV
RQGW
RGE
RDT
RG
DTSWVPPEM
I
E
R
I
EVLRGP
A
AA
R
YG
N
G
A
A
GG
V
V
NIITK
KG
SGEWH
G
SW
D
A
Y
F
NA
PE
H
KEEGATK
R
TN
FSLTGP
L
-
GD
EFSF
RLYG
NLD
--
KT
Q
A
D
AWD
IN
Q
--
G
HQSAR
AGTYATTLP
AGR
EG
V
I
N
K
DINGV
VR
WDF
AP
LQ
S
LELEA
G
YSRQGN
L
-
Y
AGD
TQ
NTNS
D
---------------
SY
T
RS
--
KY
G
D
-
E
T
NRL
Y
RQ
NY
A
LTWN
GG
WD
N
G
V
T
T
S
NWVQY
EH
-----------
TR
N
SR
IP
E
-
----
G
LA
G
-----
G
TEGKFNEK
A
TQDFVDI
D
L
D
D
V
M
L
H
SEV
N
-
-
-
LPIDF
L
V
--
NQT
----
--
--
--
--
--
LT
L
G
T
EWNQQ
R
M
KDLSS
N
TQA
L
TGT
N
T
---
GGA
I
--
D
G
V
S
A
TD
------------------
R
S
P
Y
SK
AE
I
F
S
L
F
A
EN
N
ME
LTD
S
T
I
V
T
P
GLRFD
H
H
SIVGN
N
WS
PALNISQGL
GD
D
-
---F
T
LKM
G
I
A
RA
----------------
Y
KA
P
S
LY
Q
TN
P
N
--
-
YI
L
Y
S
----
-
K
G
Q
G
CY
A
--
S
AG
GCYLQGND
D
L
KAE
T
SIN
K
EIG
L
EFK
RD
G
-
-
W
L
AG
V
T
W
FR
N
D
YR
NKIE
A
G
Y
V
AV
G
QN
AV
GT
DLYQ
W
D
N
V
P
KA
V
VEG
L
E
G
S
LN---V
P
-
VSE
TVM
W
TN
N
I
T
Y
MLK
S
E
N
K
T
T
----
-
-
-----
GDRL
S
II
PEY
TLN
S
TLSW
QA
RE
D
L
S
M
Q
TTF
T
W
YG
KQQ
P
KKY
-
N
Y
KG
QPAVG
P
ETKEIS
P
-
Y
SIV
G
L
S
AT
W
D
VTKN
V
S
LTGG
VDNLFD
K
R
L
WRAGNA
Q
T
T
G
DLA
GANY
I
A
GA
G
AYT
Y
N
-
E
PG
--
RT
WY
M
SV
NTHF
fig|481805.6.peg.3270
Escherichia coli ATCC 8739
MNKKIHSL
A
LLVNL
G
IYGVA
--
-
Q
A
Q
EP
TD
TPVSH
DDT
I
VVTA
-
A
E
Q
N
L
-
Q
AP
GV
S
---
-------------
T
I
T
A
DEIR
K
N
P
V
A
R
DVS
E
II
R
T
MPGVN
L
---
--
TGNST
S
G
Q
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
K
P
VS
S
R
NSV
RQGW
RGE
RDT
RG
DTSWVPPEM
I
E
R
I
EVLRGP
A
AA
R
YG
N
G
A
A
GG
V
V
NIITK
KG
SGEWH
G
SW
D
A
Y
F
NA
PE
H
KEEGATK
R
TN
FSLTGP
L
-
GD
EFSF
RLYG
NLD
--
KT
Q
A
D
AWD
IN
Q
--
G
HQSAR
AGTYATTLP
AGR
EG
V
I
N
K
DINGV
VR
WDF
AP
LQ
S
LELEA
G
YSRQGN
L
-
Y
AGD
TQ
NTNS
D
---------------
SY
T
RS
--
KY
G
D
-
E
T
NRL
Y
RQ
NY
A
LTWN
GG
WD
N
G
V
T
T
S
NWVQY
EH
-----------
TR
N
SR
IP
E
-
----
G
LA
G
-----
G
TEGKFNEK
A
TQDFVDI
D
L
D
D
V
M
L
H
SEV
N
-
-
-
LPIDF
L
V
--
NQT
----
--
--
--
--
--
LT
L
G
T
EWNQQ
R
M
KDLSS
N
TQA
L
TGT
N
T
---
GGA
I
--
D
G
V
S
A
TD
------------------
R
S
P
Y
SK
AE
I
F
S
L
F
A
EN
N
ME
LTD
S
T
I
V
T
P
GLRFD
H
H
SIVGN
N
WS
PALNISQGL
GD
D
-
---F
T
LKM
G
I
A
RA
----------------
Y
KA
P
S
LY
Q
TN
P
N
--
-
YI
L
Y
S
----
-
K
G
Q
G
CY
A
--
S
AG
GCYLQGND
D
L
KAE
T
SIN
K
EIG
L
EFK
RD
G
-
-
W
L
AG
V
T
W
FR
N
D
YR
NKIE
A
G
Y
V
AV
G
QN
AV
GT
DLYQ
W
D
N
V
P
KA
V
VEG
L
E
G
S
LN---V
P
-
VSE
TVM
W
TN
N
I
T
Y
MLK
S
E
N
K
T
T
----
-
-
-----
GDRL
S
II
PEY
TLN
S
TLSW
QA
RE
D
L
S
M
Q
TTF
T
W
YG
KQQ
P
KKY
-
N
Y
KG
QPAVG
P
ETKEIS
P
-
Y
SIV
G
L
S
AT
W
D
VTKN
V
S
LTGG
VDNLFD
K
R
L
WRAGNA
Q
T
T
G
DLA
GANY
I
A
GA
G
AYT
Y
N
-
E
PG
--
RT
WY
M
SV
NTHF
fig|749537.3.peg.3970
Escherichia coli MS 115-1
MNKKIHSL
A
LLVNL
G
IYGVA
--
-
Q
A
Q
EP
TD
TPVSH
DDT
I
VVTA
-
A
E
Q
N
L
-
Q
AP
GV
S
---
-------------
T
I
T
A
DEIR
K
N
P
V
A
R
DVS
E
II
R
T
MPGVN
L
---
--
TGNST
S
G
Q
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
K
P
VS
S
R
NSV
RQGW
RGE
RDT
RG
DTSWVPPEM
I
E
R
I
EVLRGP
A
AA
R
YG
N
G
A
A
GG
V
V
NIITK
KG
SGEWH
G
SW
D
A
Y
F
NA
PE
H
KEEGATK
R
TN
FSLTGP
L
-
GD
EFSF
RLYG
NLD
--
KT
Q
A
D
AWD
IN
Q
--
G
HQSAR
AGTYATTLP
AGR
EG
V
I
N
K
DINGV
VR
WDF
AP
LQ
S
LELEA
G
YSRQGN
L
-
Y
AGD
TQ
NTNS
D
---------------
SY
T
RS
--
KY
G
D
-
E
T
NRL
Y
RQ
NY
A
LTWN
GG
WD
N
G
V
T
T
S
NWVQY
EH
-----------
TR
N
SR
IP
E
-
----
G
LA
G
-----
G
TEGKFNEK
A
TQDFVDI
D
L
D
D
V
M
L
H
SEV
N
-
-
-
LPIDF
L
V
--
NQT
----
--
--
--
--
--
LT
L
G
T
EWNQQ
R
M
KDLSS
N
TQA
L
TGT
N
T
---
GGA
I
--
D
G
V
S
A
TD
------------------
R
S
P
Y
SK
AE
I
F
S
L
F
A
EN
N
ME
LTD
S
T
I
V
T
P
GLRFD
H
H
SIVGN
N
WS
PALNISQGL
GD
D
-
---F
T
LKM
G
I
A
RA
----------------
Y
KA
P
S
LY
Q
TN
P
N
--
-
YI
L
Y
S
----
-
K
G
Q
G
CY
A
--
S
AG
GCYLQGND
D
L
KAE
T
SIN
K
EIG
L
EFK
RD
G
-
-
W
L
AG
V
T
W
FR
N
D
YR
NKIE
A
G
Y
V
AV
G
QN
AV
GT
DLYQ
W
D
N
V
P
KA
V
VEG
L
E
G
S
LN---V
P
-
VSE
TVM
W
TN
N
I
T
Y
MLK
S
E
N
K
T
T
----
-
-
-----
GDRL
S
II
PEY
TLN
S
TLSW
QA
RE
D
L
S
M
Q
TTF
T
W
YG
KQQ
P
KKY
-
N
Y
KG
QPAVG
P
ETKEIS
P
-
Y
SIV
G
L
S
AT
W
D
VTKN
V
S
LTGG
VDNLFD
K
R
L
WRAGNA
Q
T
T
G
DLA
GANY
I
A
GA
G
AYT
Y
N
-
E
PG
--
RT
WY
M
SV
NTHF
fig|550676.3.peg.48
Escherichia coli B185
MNKKIHSL
A
LLVNL
G
IYGVA
--
-
Q
A
Q
EP
TD
TPVSH
DDT
I
VVTA
-
A
E
Q
N
L
-
Q
AP
GV
S
---
-------------
T
I
T
A
DEIR
K
N
P
V
A
R
DVS
E
II
R
T
MPGVN
L
---
--
TGNST
S
G
Q
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
K
P
VS
S
R
NSV
RQGW
RGE
RDT
RG
DTSWVPPEM
I
E
R
I
EVLRGP
A
AA
R
YG
N
G
A
A
GG
V
V
NIITK
KG
SGEWH
G
SW
D
A
Y
F
NA
PE
H
KEEGATK
R
TN
FSLTGP
L
-
GD
EFSF
RLYG
NLD
--
KT
Q
A
D
AWD
IN
Q
--
G
HQSAR
AGTYATTLP
AGR
EG
V
I
N
K
DINGV
VR
WDF
AP
LQ
S
LELEA
G
YSRQGN
L
-
Y
AGD
TQ
NTNS
D
---------------
AY
T
RS
--
KY
G
D
-
E
T
NRL
Y
RQ
NY
S
LTWN
GG
WD
N
G
V
T
T
S
NWVQY
EH
-----------
TR
N
SR
IP
E
-
----
G
LA
G
-----
G
TEGKFNEK
A
TQDFVDI
D
L
D
D
V
M
L
H
SEV
N
-
-
-
LPIDF
L
V
--
NQT
----
--
--
--
--
--
LT
L
G
T
EWNQQ
R
M
KDLSS
N
TQA
L
TGT
N
T
---
GGA
I
--
D
G
V
S
A
TD
------------------
R
S
P
Y
SK
AE
I
F
S
L
F
A
EN
N
ME
LTD
S
T
I
V
T
P
GLRFD
H
H
SIVGN
N
WS
PALNISQGL
GD
D
-
---F
T
LKM
G
I
A
RA
----------------
Y
KA
P
S
LY
Q
TN
P
N
--
-
YI
L
Y
S
----
-
K
G
Q
G
CY
A
--
S
AG
GCYLQGND
D
L
KAE
T
SIN
K
EIG
L
EFK
RD
G
-
-
W
L
AG
I
T
W
FR
N
D
YR
NKIE
A
G
Y
V
AV
G
QN
AV
GT
DLYQ
W
D
N
V
P
KA
V
VEG
L
E
G
S
LN---V
P
-
VSE
TVM
W
TN
N
I
T
Y
MLK
S
E
N
K
T
T
----
-
-
-----
GDRL
S
II
PEY
TLN
S
TLSW
QA
RE
D
L
S
M
Q
TTF
T
W
YG
KQQ
P
KKY
-
N
Y
KG
QPAVG
P
ETKEIS
P
-
Y
SIV
G
L
S
AT
W
D
VTKN
V
S
LTGG
VDNLFD
K
R
L
WRAGNA
Q
T
T
G
DLA
GANY
I
A
GA
G
AYT
Y
N
-
E
PG
--
RT
WY
M
SV
NTHF
fig|550677.3.peg.1003
Escherichia coli B354
MNKKIHSL
A
LLVNL
G
IYGVA
--
-
Q
A
Q
EP
TD
TPVSH
DDT
I
VVTA
-
A
E
Q
N
L
-
Q
AP
GV
S
---
-------------
T
I
T
A
DEIR
K
N
P
V
A
R
DVS
E
II
R
T
MPGVN
L
---
--
TGNST
S
G
Q
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
K
P
VS
S
R
NSV
RQGW
RGE
RDT
RG
DTSWVPPEM
I
E
R
I
EVLRGP
A
AA
R
YG
N
G
A
A
GG
V
V
NIITK
KG
SGEWH
G
SW
D
A
Y
F
NA
PE
H
KEEGATK
R
TN
FSLTGP
L
-
GD
EFSF
RLYG
NLD
--
KT
Q
A
D
AWD
IN
Q
--
G
HQSAR
AGTYATTLP
AGR
EG
V
I
N
K
DINGV
VR
WDF
AP
LQ
S
LELEA
G
YSRQGN
L
-
Y
AGD
TQ
NTNS
D
---------------
AY
T
RS
--
KY
G
D
-
E
T
NRL
Y
RQ
NY
S
LTWN
GG
WD
N
G
V
T
T
S
NWVQY
EH
-----------
TR
N
SR
IP
E
-
----
G
LA
G
-----
G
TEGKFNEK
A
TQDFVDI
D
L
D
D
V
M
L
H
SEV
N
-
-
-
LPIDF
L
V
--
NQT
----
--
--
--
--
--
LT
L
G
T
EWNQQ
R
M
KDLSS
N
TQA
L
TGT
N
T
---
GGA
I
--
D
G
V
S
A
TD
------------------
R
S
P
Y
SK
AE
I
F
S
L
F
A
EN
N
ME
LTD
S
T
I
V
T
P
GLRFD
H
H
SIVGN
N
WS
PALNISQGL
GD
D
-
---F
T
LKM
G
I
A
RA
----------------
Y
KA
P
S
LY
Q
TN
P
N
--
-
YI
L
Y
S
----
-
K
G
Q
G
CY
A
--
S
AG
GCYLQGND
D
L
KAE
T
SIN
K
EIG
L
EFK
RD
G
-
-
W
L
AG
V
T
W
FR
N
D
YR
NKIE
A
G
Y
V
AV
G
QN
AV
GT
DLYQ
W
D
N
V
P
KA
V
VEG
L
E
G
S
LN---V
P
-
VSE
TVM
W
TN
N
I
T
Y
MLK
S
E
N
K
T
T
----
-
-
-----
GDRL
S
II
PEY
TLN
S
TLSW
QA
RE
D
L
S
M
Q
TTF
T
W
YG
KQQ
P
KKY
-
N
Y
KG
QPAVG
P
ETKEIS
P
-
Y
SIV
G
L
S
AT
W
D
VTKN
V
S
LTGG
VDNLFD
K
R
L
WRAGNA
Q
T
T
G
DLA
GANY
I
A
GA
G
AYT
Y
N
-
E
PG
--
RT
WY
M
SI
NTHF
fig|656419.3.peg.860
Escherichia coli M718
MNKKIHSL
A
LLVNL
G
IYGVA
--
-
Q
A
Q
EP
TD
TPVSH
DDT
I
VVTA
-
A
E
Q
N
L
-
Q
AP
GV
S
---
-------------
T
I
T
A
DEIR
K
N
P
V
A
R
DVS
E
II
R
T
MPGVN
L
---
--
TGNST
S
G
Q
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
K
P
VS
S
R
NSV
RQGW
RGE
RDT
RG
DTSWVPPEM
I
E
R
I
EVLRGP
A
AA
R
YG
N
G
A
A
GG
V
V
NIITK
KG
SGEWH
G
SW
D
A
Y
F
NA
PE
H
KEEGATK
R
TN
FSLTGP
L
-
GD
EFSF
RLYG
NLD
--
KT
Q
A
D
AWD
IN
Q
--
G
HQSAR
AGTYATTLP
AGR
EG
V
I
N
K
DINGV
VR
WDF
AP
LQ
S
LELEA
G
YSRQGN
L
-
Y
AGD
TQ
NTNS
D
---------------
AY
T
RS
--
KY
G
D
-
E
T
NRL
Y
RQ
NY
S
LTWN
GG
WD
N
G
V
T
T
S
NWVQY
EH
-----------
TR
N
SR
IP
E
-
----
G
LA
G
-----
G
TEGKFNEK
A
TQDFVDI
D
L
D
D
V
M
L
H
SEV
N
-
-
-
LPIDF
L
V
--
NQT
----
--
--
--
--
--
LT
L
G
T
EWNQQ
R
M
KDLSS
N
TQA
L
TGT
N
T
---
GGA
I
--
D
G
V
S
A
TD
------------------
R
S
P
Y
SK
AE
I
F
S
L
F
A
EN
N
ME
LTD
S
T
I
V
T
P
GLRFD
H
H
SIVGN
N
WS
PALNISQGL
GD
D
-
---F
T
LKM
G
I
A
RA
----------------
Y
KA
P
S
LY
Q
TN
P
N
--
-
YI
L
Y
S
----
-
K
G
Q
G
CY
A
--
S
AG
GCYLQGND
D
L
KAE
T
SIN
K
EIG
L
EFK
RD
G
-
-
W
L
AG
I
T
W
FR
N
D
YR
NKIE
A
G
Y
V
AV
G
QN
AV
GT
DLYQ
W
D
N
V
P
KA
V
VEG
L
E
G
S
LN---V
P
-
VSE
TVM
W
TN
N
I
T
Y
MLK
S
E
N
K
T
T
----
-
-
-----
GDRL
S
II
PEY
TLN
S
TLSW
QA
RE
D
L
S
M
Q
TTF
T
W
YG
KQQ
P
KKY
-
N
Y
KG
QPAVG
P
ETKEIS
P
-
Y
SIV
G
L
S
AT
W
D
VTKN
V
S
LTGG
VDNLFD
K
R
L
WRAGNA
Q
T
T
G
DLA
GANY
I
A
GA
G
AYT
Y
N
-
E
PG
--
RT
WY
M
SV
NTHF
fig|331112.3.peg.589
Escherichia coli HS
MNKKIHSL
A
LLVNL
G
IYGVA
--
-
Q
A
Q
EP
TD
TPVSH
DDT
I
VVTA
-
A
E
Q
N
L
-
Q
AP
GV
S
---
-------------
T
I
T
A
DEIR
K
N
P
V
A
R
DVS
E
II
R
T
MPGVN
L
---
--
TGNST
S
G
Q
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
K
P
VS
S
R
NSV
RQGW
RGE
RDT
RG
DTSWVPPEM
I
E
R
I
EVLRGP
A
AA
R
YG
N
G
A
A
GG
V
V
NIITK
KG
SGEWH
G
SW
D
A
Y
F
NA
PE
H
KEEGATK
R
TN
FSLTGP
L
-
GD
EFSF
RLYG
NLD
--
KT
Q
A
D
AWD
IN
Q
--
G
HQSAR
AGTYATTLP
AGR
EG
V
I
N
K
DINGV
VR
WDF
AP
LQ
S
LELEA
G
YSRQGN
L
-
Y
AGD
TQ
NTNS
D
---------------
SY
T
RS
--
KY
G
D
-
E
T
NRL
Y
RQ
NY
A
LTWN
GG
WD
N
G
V
T
T
S
NWVQY
EH
-----------
TR
N
SR
IP
E
-
----
G
LA
G
-----
G
TEGKFNEK
A
TQDFVDI
D
L
D
D
V
M
L
H
SEV
N
-
-
-
LPIDF
L
V
--
NQT
----
--
--
--
--
--
LT
L
G
T
EWNQQ
R
M
KDLSS
N
TQV
L
TGT
N
T
---
GGA
I
--
D
G
V
S
A
TD
------------------
R
S
P
Y
SK
AE
I
F
S
L
F
A
EN
N
ME
LTD
S
T
I
V
T
P
GLRFD
H
H
SIVGN
N
WS
PALNISQGL
GD
D
-
---F
T
LKM
G
I
A
RA
----------------
Y
KA
P
S
LY
Q
TN
P
N
--
-
YI
L
Y
S
----
-
K
G
Q
G
CY
A
--
S
AG
GCYLQGND
D
L
KAE
T
SIN
K
EIG
L
EFK
RD
G
-
-
W
L
AG
V
T
W
FR
N
D
YR
NKIE
A
G
Y
V
AV
G
QN
AV
GT
DLYQ
W
D
N
V
P
KA
V
VEG
L
E
G
S
LN---V
P
-
VSE
TVM
W
TN
N
I
T
Y
MLK
S
E
N
K
T
T
----
-
-
-----
GDRL
S
II
PEY
TLN
S
TLSW
QA
RE
D
L
S
M
Q
TTF
T
W
YG
KQQ
P
KKY
-
N
Y
KG
QPAVG
P
ETKEIS
P
-
Y
SIV
G
L
S
AT
W
D
VTKN
V
S
LTGG
VDNLFD
K
R
L
WRAGNA
Q
T
T
G
DLA
GANY
I
A
GA
G
AYT
Y
N
-
E
PG
--
RT
WY
M
SV
NTHF
fig|331112.6.peg.616
Escherichia coli HS
MNKKIHSL
A
LLVNL
G
IYGVA
--
-
Q
A
Q
EP
TD
TPVSH
DDT
I
VVTA
-
A
E
Q
N
L
-
Q
AP
GV
S
---
-------------
T
I
T
A
DEIR
K
N
P
V
A
R
DVS
E
II
R
T
MPGVN
L
---
--
TGNST
S
G
Q
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
K
P
VS
S
R
NSV
RQGW
RGE
RDT
RG
DTSWVPPEM
I
E
R
I
EVLRGP
A
AA
R
YG
N
G
A
A
GG
V
V
NIITK
KG
SGEWH
G
SW
D
A
Y
F
NA
PE
H
KEEGATK
R
TN
FSLTGP
L
-
GD
EFSF
RLYG
NLD
--
KT
Q
A
D
AWD
IN
Q
--
G
HQSAR
AGTYATTLP
AGR
EG
V
I
N
K
DINGV
VR
WDF
AP
LQ
S
LELEA
G
YSRQGN
L
-
Y
AGD
TQ
NTNS
D
---------------
SY
T
RS
--
KY
G
D
-
E
T
NRL
Y
RQ
NY
A
LTWN
GG
WD
N
G
V
T
T
S
NWVQY
EH
-----------
TR
N
SR
IP
E
-
----
G
LA
G
-----
G
TEGKFNEK
A
TQDFVDI
D
L
D
D
V
M
L
H
SEV
N
-
-
-
LPIDF
L
V
--
NQT
----
--
--
--
--
--
LT
L
G
T
EWNQQ
R
M
KDLSS
N
TQV
L
TGT
N
T
---
GGA
I
--
D
G
V
S
A
TD
------------------
R
S
P
Y
SK
AE
I
F
S
L
F
A
EN
N
ME
LTD
S
T
I
V
T
P
GLRFD
H
H
SIVGN
N
WS
PALNISQGL
GD
D
-
---F
T
LKM
G
I
A
RA
----------------
Y
KA
P
S
LY
Q
TN
P
N
--
-
YI
L
Y
S
----
-
K
G
Q
G
CY
A
--
S
AG
GCYLQGND
D
L
KAE
T
SIN
K
EIG
L
EFK
RD
G
-
-
W
L
AG
V
T
W
FR
N
D
YR
NKIE
A
G
Y
V
AV
G
QN
AV
GT
DLYQ
W
D
N
V
P
KA
V
VEG
L
E
G
S
LN---V
P
-
VSE
TVM
W
TN
N
I
T
Y
MLK
S
E
N
K
T
T
----
-
-
-----
GDRL
S
II
PEY
TLN
S
TLSW
QA
RE
D
L
S
M
Q
TTF
T
W
YG
KQQ
P
KKY
-
N
Y
KG
QPAVG
P
ETKEIS
P
-
Y
SIV
G
L
S
AT
W
D
VTKN
V
S
LTGG
VDNLFD
K
R
L
WRAGNA
Q
T
T
G
DLA
GANY
I
A
GA
G
AYT
Y
N
-
E
PG
--
RT
WY
M
SV
NTHF
fig|331111.12.peg.909
Escherichia coli E24377A
MNKKIHSL
A
LLVNL
G
IYGVA
--
-
Q
A
Q
EP
TD
TPVSH
DDT
I
VVTA
-
A
E
Q
N
L
-
Q
AP
GV
S
---
-------------
T
I
T
A
DEIR
K
N
P
V
A
R
DVS
E
II
R
T
MPGVN
L
---
--
TGNST
S
G
Q
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
K
P
VS
S
R
NSV
RQGW
RGE
RDT
RG
DTSWVPPEM
I
E
R
I
EVLRGP
A
AA
R
YG
N
G
A
A
GG
V
V
NIITK
KG
SGEWH
G
SW
D
A
Y
F
NA
PE
H
KEEGATK
R
TN
FSLTGP
L
-
GD
EFSF
RLYG
NLD
--
KT
Q
A
D
AWD
IN
Q
--
G
HQSAR
AGTYATTLP
AGR
EG
V
I
N
K
DINGV
VR
WDF
AP
LQ
S
LELEA
G
YSRQGN
L
-
Y
AGD
TQ
NTNS
D
---------------
AY
T
RS
--
KY
G
D
-
E
T
NRL
Y
RQ
NY
S
LTWN
GG
WD
N
G
V
T
T
S
NWVQY
EH
-----------
TR
N
SR
IP
E
-
----
G
LA
G
-----
G
TEGKFNEK
A
TQDFVDI
D
L
D
D
V
M
L
H
SEV
N
-
-
-
LPLDF
L
V
--
NQT
----
--
--
--
--
--
LT
L
G
T
EWNQQ
R
M
KDLSS
N
TQA
L
TGT
N
T
---
GGA
I
--
D
G
V
S
A
TD
------------------
R
S
P
Y
SK
AE
I
F
S
L
F
A
EN
N
ME
LTD
S
T
I
V
T
P
GLRFD
H
H
SIVGN
N
WS
PALNISQGL
GD
D
-
---F
T
LKM
G
I
A
RA
----------------
Y
KA
P
S
LY
Q
TN
P
N
--
-
YI
L
Y
S
----
-
K
G
Q
G
CY
A
--
S
AG
GCYLQGND
D
L
KAE
T
SIN
K
EIG
L
EFK
RD
G
-
-
W
L
AG
V
T
W
FR
N
D
YR
NKIE
A
G
Y
V
AV
G
QN
AV
GT
DLYQ
W
D
N
V
P
KA
V
VEG
L
E
G
S
LN---V
P
-
VSE
TVM
W
TN
N
I
T
Y
MLK
S
E
N
K
T
T
----
-
-
-----
GDRL
S
II
PEY
TLN
S
TLSW
QA
RE
D
L
S
M
Q
TTF
T
W
YG
KQQ
P
KKY
-
N
Y
KG
QPAVG
P
ETKEIS
P
-
Y
SIV
G
L
S
AT
W
D
VTKN
V
S
LTGG
VDNLFD
K
R
L
WRAGNA
Q
T
T
G
DLA
GANY
I
A
GA
G
AYT
Y
N
-
E
PG
--
RT
WY
M
SV
NTHF
fig|331111.3.peg.3133
Escherichia coli E24377A
MNKKIHSL
A
LLVNL
G
IYGVA
--
-
Q
A
Q
EP
TD
TPVSH
DDT
I
VVTA
-
A
E
Q
N
L
-
Q
AP
GV
S
---
-------------
T
I
T
A
DEIR
K
N
P
V
A
R
DVS
E
II
R
T
MPGVN
L
---
--
TGNST
S
G
Q
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
K
P
VS
S
R
NSV
RQGW
RGE
RDT
RG
DTSWVPPEM
I
E
R
I
EVLRGP
A
AA
R
YG
N
G
A
A
GG
V
V
NIITK
KG
SGEWH
G
SW
D
A
Y
F
NA
PE
H
KEEGATK
R
TN
FSLTGP
L
-
GD
EFSF
RLYG
NLD
--
KT
Q
A
D
AWD
IN
Q
--
G
HQSAR
AGTYATTLP
AGR
EG
V
I
N
K
DINGV
VR
WDF
AP
LQ
S
LELEA
G
YSRQGN
L
-
Y
AGD
TQ
NTNS
D
---------------
AY
T
RS
--
KY
G
D
-
E
T
NRL
Y
RQ
NY
S
LTWN
GG
WD
N
G
V
T
T
S
NWVQY
EH
-----------
TR
N
SR
IP
E
-
----
G
LA
G
-----
G
TEGKFNEK
A
TQDFVDI
D
L
D
D
V
M
L
H
SEV
N
-
-
-
LPLDF
L
V
--
NQT
----
--
--
--
--
--
LT
L
G
T
EWNQQ
R
M
KDLSS
N
TQA
L
TGT
N
T
---
GGA
I
--
D
G
V
S
A
TD
------------------
R
S
P
Y
SK
AE
I
F
S
L
F
A
EN
N
ME
LTD
S
T
I
V
T
P
GLRFD
H
H
SIVGN
N
WS
PALNISQGL
GD
D
-
---F
T
LKM
G
I
A
RA
----------------
Y
KA
P
S
LY
Q
TN
P
N
--
-
YI
L
Y
S
----
-
K
G
Q
G
CY
A
--
S
AG
GCYLQGND
D
L
KAE
T
SIN
K
EIG
L
EFK
RD
G
-
-
W
L
AG
V
T
W
FR
N
D
YR
NKIE
A
G
Y
V
AV
G
QN
AV
GT
DLYQ
W
D
N
V
P
KA
V
VEG
L
E
G
S
LN---V
P
-
VSE
TVM
W
TN
N
I
T
Y
MLK
S
E
N
K
T
T
----
-
-
-----
GDRL
S
II
PEY
TLN
S
TLSW
QA
RE
D
L
S
M
Q
TTF
T
W
YG
KQQ
P
KKY
-
N
Y
KG
QPAVG
P
ETKEIS
P
-
Y
SIV
G
L
S
AT
W
D
VTKN
V
S
LTGG
VDNLFD
K
R
L
WRAGNA
Q
T
T
G
DLA
GANY
I
A
GA
G
AYT
Y
N
-
E
PG
--
RT
WY
M
SV
NTHF
fig|679205.4.peg.587
Escherichia coli MS 124-1
MNKKIHSL
A
LLVNL
G
IYGVA
--
-
Q
A
Q
EP
TD
TPVSH
DDT
I
VVTA
-
A
E
Q
N
L
-
Q
AP
GV
S
---
-------------
T
I
T
A
DEIR
K
N
P
V
A
R
DVS
E
II
R
T
MPGVN
L
---
--
TGNST
S
G
Q
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
K
P
VS
S
R
NSV
RQGW
RGE
RDT
RG
DTSWVPPEM
I
E
R
I
EVLRGP
A
AA
R
YG
N
G
A
A
GG
V
V
NIITK
KG
SGEWH
G
SW
D
A
Y
F
NA
PE
H
KEEGATK
R
TN
FSLTGP
L
-
GD
EFSF
RLYG
NLD
--
KT
Q
A
D
AWD
IN
Q
--
G
HQSAR
AGTYATTLP
AGR
EG
V
I
N
K
DINGV
VR
WDF
AP
LQ
S
LELEA
G
YSRQGN
L
-
Y
AGD
TQ
NTNS
D
---------------
AY
T
RS
--
KY
G
D
-
E
T
NRL
Y
RQ
NY
S
LTWN
GG
WD
N
G
V
T
T
S
NWVQY
EH
-----------
TR
N
SR
IP
E
-
----
G
LA
G
-----
G
TEGKFNEK
A
TQDFVDI
D
L
D
D
V
M
L
H
SEV
N
-
-
-
LPLDF
L
V
--
NQT
----
--
--
--
--
--
LT
L
G
T
EWNQQ
R
M
KDLSS
N
TQA
L
TGT
N
T
---
GGA
I
--
D
G
V
S
A
TD
------------------
R
S
P
Y
SK
AE
I
F
S
L
F
A
EN
N
ME
LTD
S
T
I
V
T
P
GLRFD
H
H
SIVGN
N
WS
PALNISQGL
GD
D
-
---F
T
LKM
G
I
A
RA
----------------
Y
KA
P
S
LY
Q
TN
P
N
--
-
YI
L
Y
S
----
-
K
G
Q
G
CY
A
--
S
AG
GCYLQGND
D
L
KAE
T
SIN
K
EIG
L
EFK
RD
G
-
-
W
L
AG
V
T
W
FR
N
D
YR
NKIE
A
G
Y
V
AV
G
QN
AV
GT
DLYQ
W
D
N
V
P
KA
V
VEG
L
E
G
S
LN---V
P
-
VSE
TVM
W
TN
N
I
T
Y
MLK
S
E
N
K
T
T
----
-
-
-----
GDRL
S
II
PEY
TLN
S
TLSW
QA
RE
D
L
S
M
Q
TTF
T
W
YG
KQQ
P
KKY
-
N
Y
KG
QPAVG
P
ETKEIS
P
-
Y
SIV
G
L
S
AT
W
D
VTKN
V
S
LTGG
VDNLFD
K
R
L
WRAGNA
Q
T
T
G
DLA
GANY
I
A
GA
G
AYT
Y
N
-
E
PG
--
RT
WY
M
SV
NTHF
fig|749533.3.peg.5391
Escherichia coli MS 84-1
MNKKIHSL
A
LLVNL
G
IYGVA
--
-
Q
A
Q
EP
TD
TPVSH
DDT
I
VVTA
-
A
E
Q
N
L
-
Q
AP
GV
S
---
-------------
T
I
T
A
DEIR
K
N
P
V
A
R
DVS
E
II
R
T
MPGVN
L
---
--
TGNST
S
G
Q
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
K
P
VS
S
R
NSV
RQGW
RGE
RDT
RG
DTSWVPPEM
I
E
R
I
EVLRGP
A
AA
R
YG
N
G
A
A
GG
V
V
NIITK
KG
SGEWH
G
SW
D
A
Y
F
NA
PE
H
KEEGATK
R
TN
FSLTGP
L
-
GD
EFSF
RLYG
NLD
--
KT
Q
A
D
AWD
IN
Q
--
G
HQSAR
AGTYATTLP
AGR
EG
V
I
N
K
DINGV
VR
WDF
AP
LQ
S
LELEA
G
YSRQGN
L
-
Y
AGD
TQ
NTNS
D
---------------
AY
T
RS
--
KY
G
D
-
E
T
NRL
Y
RQ
NY
S
LTWN
GG
WD
N
G
V
T
T
S
NWVQY
EH
-----------
TR
N
SR
IP
E
-
----
G
LA
G
-----
G
TEGKFNEK
A
TQDFVDI
D
L
D
D
V
M
L
H
SEV
N
-
-
-
LPLDF
L
V
--
NQT
----
--
--
--
--
--
LT
L
G
T
EWNQQ
R
M
KDLSS
N
TQA
L
TGT
N
T
---
GGA
I
--
D
G
V
S
A
TD
------------------
R
S
P
Y
SK
AE
I
F
S
L
F
A
EN
N
ME
LTD
S
T
I
V
T
P
GLRFD
H
H
SIVGN
N
WS
PALNISQGL
GD
D
-
---F
T
LKM
G
I
A
RA
----------------
Y
KA
P
S
LY
Q
TN
P
N
--
-
YI
L
Y
S
----
-
K
G
Q
G
CY
A
--
S
AG
GCYLQGND
D
L
KAE
T
SIN
K
EIG
L
EFK
RD
G
-
-
W
L
AG
V
T
W
FR
N
D
YR
NKIE
A
G
Y
V
AV
G
QN
AV
GT
DLYQ
W
D
N
V
P
KA
V
VEG
L
E
G
S
LN---V
P
-
VSE
TVM
W
TN
N
I
T
Y
MLK
S
E
N
K
T
T
----
-
-
-----
GDRL
S
II
PEY
TLN
S
TLSW
QA
RE
D
L
S
M
Q
TTF
T
W
YG
KQQ
P
KKY
-
N
Y
KG
QPAVG
P
ETKEIS
P
-
Y
SIV
G
L
S
AT
W
D
VTKN
V
S
LTGG
VDNLFD
K
R
L
WRAGNA
Q
T
T
G
DLA
GANY
I
A
GA
G
AYT
Y
N
-
E
PG
--
RT
WY
M
SV
NTHF
fig|409438.11.peg.774
Escherichia coli SE11
MNKKIHSL
A
LLVNL
G
IYGVA
--
-
Q
A
Q
EP
TD
TPVSH
DDT
I
VVTA
-
A
E
Q
N
L
-
Q
AP
GV
S
---
-------------
T
I
T
A
DEIR
K
N
P
V
A
R
DVS
E
II
R
T
MPGVN
L
---
--
TGNST
S
G
Q
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
K
P
VS
S
R
NSV
RQGW
RGE
RDT
RG
DTSWVPPEM
I
E
R
I
EVLRGP
A
AA
R
YG
N
G
A
A
GG
V
V
NIITK
KG
SGEWH
G
SW
D
A
Y
F
NA
PE
H
KEEGATK
R
TN
FSLTGP
L
-
GD
EFSF
RLYG
NLD
--
KT
Q
A
D
AWD
IN
Q
--
G
HQSAR
AGTYATTLP
AGR
EG
V
I
N
K
DINGV
VR
WDF
AP
LQ
S
LELEA
G
YSRQGN
L
-
Y
AGD
TQ
NTNS
D
---------------
AY
T
RS
--
KY
G
D
-
E
T
NRL
Y
RQ
NY
S
LTWN
GG
WD
N
G
V
T
T
S
NWVQY
EH
-----------
TR
N
SR
IP
E
-
----
G
LA
G
-----
G
TEGKFNEK
A
TQDFVDI
D
L
D
D
V
M
L
H
SEV
N
-
-
-
LPLDF
L
V
--
NQT
----
--
--
--
--
--
LT
L
G
T
EWNQQ
R
M
KDLSS
N
TQA
L
TGT
N
T
---
GGA
I
--
D
G
V
S
A
TD
------------------
R
S
P
Y
SK
AE
I
F
S
L
F
A
EN
N
ME
LTD
S
T
I
V
T
P
GLRFD
H
H
SIVGN
N
WS
PALNISQGL
GD
D
-
---F
T
LKM
G
I
A
RA
----------------
Y
KA
P
S
LY
Q
TN
P
N
--
-
YI
L
Y
S
----
-
K
G
Q
G
CY
A
--
S
AG
GCYLQGND
D
L
KAE
T
SIN
K
EIG
L
EFK
RD
G
-
-
W
L
AG
V
T
W
FR
N
D
YR
NKIE
A
G
Y
V
AV
G
QN
AV
GT
DLYQ
W
D
N
V
P
KA
V
VEG
L
E
G
S
LN---V
P
-
VSE
TVM
W
TN
N
I
T
Y
MLK
S
E
N
K
T
T
----
-
-
-----
GDRL
S
II
PEY
TLN
S
TLSW
QA
RE
D
L
S
M
Q
TTF
T
W
YG
KQQ
P
KKY
-
N
Y
KG
QPAVG
P
ETKEIS
P
-
Y
SIV
G
L
S
AT
W
D
VTKN
V
S
LTGG
VDNLFD
K
R
L
WRAGNA
Q
T
T
G
DLA
GANY
I
A
GA
G
AYT
Y
N
-
E
PG
--
RT
WY
M
SV
NTHF
fig|749527.3.peg.4221
Escherichia coli MS 21-1
MNKKIHSL
A
LLVNL
G
IYGVA
--
-
Q
A
Q
EP
TD
TPVSH
DDT
I
VVTA
-
A
E
Q
N
L
-
Q
AP
GV
S
---
-------------
T
I
T
A
DEIR
K
N
P
V
A
R
DVS
E
II
R
T
MPGVN
L
---
--
TGNST
S
G
Q
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
K
P
VS
S
R
NSV
RQGW
RGE
RDT
RG
DTSWVPPEM
I
E
R
I
EVLRGP
A
AA
R
YG
N
G
A
A
GG
V
V
NIITK
KG
SGEWH
G
SW
D
A
Y
F
NA
PE
H
KEEGATK
R
TN
FSLTGP
L
-
GD
EFSF
RLYG
NLD
--
KT
Q
A
D
AWD
IN
Q
--
G
HQSAR
AGTYATTLP
AGR
EG
V
I
N
K
DINGV
VR
WDF
AP
LQ
S
LELEA
G
YSRQGN
L
-
Y
AGD
TQ
NTNS
D
---------------
SY
T
RS
--
KY
G
D
-
E
T
NRL
Y
RQ
NY
S
LTWN
GG
WD
N
G
V
T
T
S
NWVQY
EH
-----------
TR
N
SR
IP
E
-
----
G
LA
G
-----
G
TEGKFNEK
A
TQDFVDI
D
L
D
D
V
M
L
H
SEV
N
-
-
-
LPIDF
L
V
--
NQT
----
--
--
--
--
--
LT
L
G
T
EWNQQ
R
M
KDLSS
N
TQA
L
TGT
N
T
---
GGA
I
--
D
G
V
S
A
TD
------------------
R
S
P
Y
SK
AE
I
F
S
L
F
A
EN
N
ME
LTD
S
T
I
V
T
P
GLRFD
H
H
SIVGN
N
WS
PALNISQGL
GD
D
-
---F
T
LKM
G
I
A
RA
----------------
Y
KA
P
S
LY
Q
TN
P
N
--
-
YI
L
Y
S
----
-
K
G
Q
G
CY
A
--
S
AG
GCYLQGND
D
L
KAE
T
SIN
K
EIG
L
EFK
RD
G
-
-
W
L
AG
V
T
W
FR
N
D
YR
NKIE
A
G
Y
V
AV
G
QN
AV
GT
DLYQ
W
D
N
V
P
KA
V
VEG
L
E
G
S
LN---V
P
-
VSE
TVM
W
TN
N
I
T
Y
MLK
S
E
N
K
T
T
----
-
-
-----
GDRL
S
II
PEY
TLN
S
TLSW
QA
RE
D
L
S
M
Q
TTF
T
W
YG
KQQ
P
KKY
-
N
Y
KG
QPAVG
P
ETKEIS
P
-
Y
SIV
G
L
S
AT
W
D
VTKN
V
S
LTGG
VDNLFD
K
R
L
WRAGNA
Q
T
T
G
DLA
GANY
I
A
GA
G
AYT
Y
N
-
E
PG
--
RT
WY
M
SV
NTHF
fig|199310.1.peg.644
Escherichia coli CFT073
MNKKIHSL
A
LLVNL
G
IYGVA
--
-
Q
A
Q
EP
TD
TPVSH
DDT
I
VVTA
-
A
E
Q
N
L
-
Q
AP
GV
S
---
-------------
T
I
T
A
DEIR
K
N
P
V
A
R
DVS
E
II
R
T
MPGVN
L
---
--
TGNST
S
G
Q
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
K
P
VS
S
R
NSV
RQGW
RGE
RDT
RG
DTSWVPPEM
I
E
R
I
EVLRGP
A
AA
R
YG
N
G
A
A
GG
V
V
NIITK
KG
SGEWH
G
SW
D
A
Y
F
NA
PE
H
KEEGATK
R
TN
FSLTGP
L
-
GD
EFSF
RLYG
NLD
--
KT
Q
A
D
AWD
IN
Q
--
G
HQSAR
AGTYATTLP
AGR
EG
V
I
N
K
DINGV
VR
WDF
AP
LQ
S
LELEA
G
YSRQGN
L
-
Y
AGD
TQ
NTNS
D
---------------
AY
T
RS
--
KY
G
D
-
E
T
NRL
Y
RQ
NY
S
LTWN
GG
WD
N
G
V
T
T
S
NWVQY
EH
-----------
TR
N
SR
IP
E
-
----
G
LA
G
-----
G
TEGKFNEK
A
AQDFVDI
D
L
D
D
V
M
L
H
SEV
N
-
-
-
LPIDF
L
V
--
NQT
----
--
--
--
--
--
LT
L
G
T
EWNQQ
R
M
KDLSS
N
TQA
L
TGT
N
T
---
GGA
I
--
D
G
V
S
A
TD
------------------
R
S
P
Y
SK
AE
I
F
S
L
F
A
EN
N
ME
LTD
S
T
I
V
T
P
GLRFD
H
H
SIVGN
N
WS
PALNISQGL
GD
D
-
---F
T
LKM
G
I
A
RA
----------------
Y
KA
P
S
LY
Q
TN
P
N
--
-
YI
L
Y
S
----
-
K
G
Q
G
CY
A
--
S
AG
GCYLQGND
D
L
KAE
T
SIN
K
EIG
L
EFK
RD
G
-
-
W
L
AG
V
T
W
FR
N
D
YR
NKIE
A
G
Y
V
AV
G
QN
AV
GT
DLYQ
W
D
N
V
P
KA
V
VEG
L
E
G
S
LN---V
P
-
VSE
TVM
W
TN
N
I
T
Y
MLK
S
E
N
K
T
T
----
-
-
-----
GDRL
S
II
PEY
TLN
S
TLSW
QA
RE
D
L
S
M
Q
TTF
T
W
YG
KQQ
P
KKY
-
N
Y
KG
QPAVG
P
ETKEIS
P
-
Y
SIV
G
L
S
AT
W
D
VTKN
V
S
LTGG
VDNLFD
K
R
L
WRAGNA
Q
T
T
G
DLA
GANY
I
A
GA
G
AYT
Y
N
-
E
PG
--
RT
WY
M
SI
NTHF
fig|199310.4.peg.635
Escherichia coli CFT073
MNKKIHSL
A
LLVNL
G
IYGVA
--
-
Q
A
Q
EP
TD
TPVSH
DDT
I
VVTA
-
A
E
Q
N
L
-
Q
AP
GV
S
---
-------------
T
I
T
A
DEIR
K
N
P
V
A
R
DVS
E
II
R
T
MPGVN
L
---
--
TGNST
S
G
Q
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
K
P
VS
S
R
NSV
RQGW
RGE
RDT
RG
DTSWVPPEM
I
E
R
I
EVLRGP
A
AA
R
YG
N
G
A
A
GG
V
V
NIITK
KG
SGEWH
G
SW
D
A
Y
F
NA
PE
H
KEEGATK
R
TN
FSLTGP
L
-
GD
EFSF
RLYG
NLD
--
KT
Q
A
D
AWD
IN
Q
--
G
HQSAR
AGTYATTLP
AGR
EG
V
I
N
K
DINGV
VR
WDF
AP
LQ
S
LELEA
G
YSRQGN
L
-
Y
AGD
TQ
NTNS
D
---------------
AY
T
RS
--
KY
G
D
-
E
T
NRL
Y
RQ
NY
S
LTWN
GG
WD
N
G
V
T
T
S
NWVQY
EH
-----------
TR
N
SR
IP
E
-
----
G
LA
G
-----
G
TEGKFNEK
A
AQDFVDI
D
L
D
D
V
M
L
H
SEV
N
-
-
-
LPIDF
L
V
--
NQT
----
--
--
--
--
--
LT
L
G
T
EWNQQ
R
M
KDLSS
N
TQA
L
TGT
N
T
---
GGA
I
--
D
G
V
S
A
TD
------------------
R
S
P
Y
SK
AE
I
F
S
L
F
A
EN
N
ME
LTD
S
T
I
V
T
P
GLRFD
H
H
SIVGN
N
WS
PALNISQGL
GD
D
-
---F
T
LKM
G
I
A
RA
----------------
Y
KA
P
S
LY
Q
TN
P
N
--
-
YI
L
Y
S
----
-
K
G
Q
G
CY
A
--
S
AG
GCYLQGND
D
L
KAE
T
SIN
K
EIG
L
EFK
RD
G
-
-
W
L
AG
V
T
W
FR
N
D
YR
NKIE
A
G
Y
V
AV
G
QN
AV
GT
DLYQ
W
D
N
V
P
KA
V
VEG
L
E
G
S
LN---V
P
-
VSE
TVM
W
TN
N
I
T
Y
MLK
S
E
N
K
T
T
----
-
-
-----
GDRL
S
II
PEY
TLN
S
TLSW
QA
RE
D
L
S
M
Q
TTF
T
W
YG
KQQ
P
KKY
-
N
Y
KG
QPAVG
P
ETKEIS
P
-
Y
SIV
G
L
S
AT
W
D
VTKN
V
S
LTGG
VDNLFD
K
R
L
WRAGNA
Q
T
T
G
DLA
GANY
I
A
GA
G
AYT
Y
N
-
E
PG
--
RT
WY
M
SI
NTHF
fig|216593.1.peg.3037
Escherichia coli E2348/69
MNKKIHSL
A
LLVNL
G
IYGVA
--
-
Q
A
Q
EP
TD
TPVSH
DDT
I
VVTA
-
A
E
Q
N
L
-
Q
AP
GV
S
---
-------------
T
I
T
A
DEIR
K
N
P
V
A
R
DVS
E
II
R
T
MPGVN
L
---
--
TGNST
S
G
Q
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
K
P
VS
S
R
NSV
RQGW
RGE
RDT
RG
DTSWVPPEM
I
E
R
I
EVLRGP
A
AA
R
YG
N
G
A
A
GG
V
V
NIITK
KG
SGEWH
G
SW
D
A
Y
F
NA
PE
H
KEEGATK
R
TN
FSLTGP
L
-
GD
EFSF
RLYG
NLD
--
KT
Q
A
D
AWD
IN
Q
--
G
HQSAR
AGTYATTLP
AGR
EG
V
I
N
K
DINGV
VR
WDF
AP
LQ
S
LELEA
G
YSRQGN
L
-
Y
AGD
TQ
NTNS
D
---------------
AY
T
RS
--
KY
G
D
-
E
T
NRL
Y
RQ
NY
S
LTWN
GG
WD
N
G
V
T
T
S
NWVQY
EH
-----------
TR
N
SR
IP
E
-
----
G
LA
G
-----
G
TEGKFNEK
A
AQDFVDI
D
L
D
D
V
M
L
H
SEV
N
-
-
-
LPIDF
L
V
--
NQT
----
--
--
--
--
--
LT
L
G
T
EWNQQ
R
M
KDLSS
N
TQA
L
TGT
N
T
---
GGA
I
--
D
G
V
S
A
TD
------------------
R
S
P
Y
SK
AE
I
F
S
L
F
A
EN
N
ME
LTD
S
T
I
V
T
P
GLRFD
H
H
SIVGN
N
WS
PALNISQGL
GD
D
-
---F
T
LKM
G
I
A
RA
----------------
Y
KA
P
S
LY
Q
TN
P
N
--
-
YI
L
Y
S
----
-
K
G
Q
G
CY
A
--
S
AG
GCYLQGND
D
L
KAE
T
SIN
K
EIG
L
EFK
RD
G
-
-
W
L
AG
V
T
W
FR
N
D
YR
NKIE
A
G
Y
V
AV
G
QN
AV
GT
DLYQ
W
D
N
V
P
KA
V
VEG
L
E
G
S
LN---V
P
-
VSE
TVM
W
TN
N
I
T
Y
MLK
S
E
N
K
T
T
----
-
-
-----
GDRL
S
II
PEY
TLN
S
TLSW
QA
RE
D
L
S
M
Q
TTF
T
W
YG
KQQ
P
KKY
-
N
Y
KG
QPAVG
P
ETKEIS
P
-
Y
SIV
G
L
S
AT
W
D
VTKN
V
S
LTGG
VDNLFD
K
R
L
WRAGNA
Q
T
T
G
DLA
GANY
I
A
GA
G
AYT
Y
N
-
E
PG
--
RT
WY
M
SI
NTHF
fig|714962.3.peg.610
Escherichia coli IHE3034
MNKKIHSL
A
LLVNL
G
IYGVA
--
-
Q
A
Q
EP
TD
TPVSH
DDT
I
VVTA
-
A
E
Q
N
L
-
Q
AP
GV
S
---
-------------
T
I
T
A
DEIR
K
N
P
V
A
R
DVS
E
II
R
T
MPGVN
L
---
--
TGNST
S
G
Q
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
K
P
VS
S
R
NSV
RQGW
RGE
RDT
RG
DTSWVPPEM
I
E
R
I
EVLRGP
A
AA
R
YG
N
G
A
A
GG
V
V
NIITK
KG
SGEWH
G
SW
D
A
Y
F
NA
PE
H
KEEGATK
R
TN
FSLTGP
L
-
GD
EFSF
RLYG
NLD
--
KT
Q
A
D
AWD
IN
Q
--
G
HQSAR
AGTYATTLP
AGR
EG
V
I
N
K
DINGV
VR
WDF
AP
LQ
S
LELEA
G
YSRQGN
L
-
Y
AGD
TQ
NTNS
D
---------------
AY
T
RS
--
KY
G
D
-
E
T
NRL
Y
RQ
NY
S
LTWN
GG
WD
N
G
V
T
T
S
NWVQY
EH
-----------
TR
N
SR
IP
E
-
----
G
LA
G
-----
G
TEGKFNEK
A
AQDFVDI
D
L
D
D
V
M
L
H
SEV
N
-
-
-
LPIDF
L
V
--
NQT
----
--
--
--
--
--
LT
L
G
T
EWNQQ
R
M
KDLSS
N
TQA
L
TGT
N
T
---
GGA
I
--
D
G
V
S
A
TD
------------------
R
S
P
Y
SK
AE
I
F
S
L
F
A
EN
N
ME
LTD
S
T
I
V
T
P
GLRFD
H
H
SIVGN
N
WS
PALNISQGL
GD
D
-
---F
T
LKM
G
I
A
RA
----------------
Y
KA
P
S
LY
Q
TN
P
N
--
-
YI
L
Y
S
----
-
K
G
Q
G
CY
A
--
S
AG
GCYLQGND
D
L
KAE
T
SIN
K
EIG
L
EFK
RD
G
-
-
W
L
AG
V
T
W
FR
N
D
YR
NKIE
A
G
Y
V
AV
G
QN
AV
GT
DLYQ
W
D
N
V
P
KA
V
VEG
L
E
G
S
LN---V
P
-
VSE
TVM
W
TN
N
I
T
Y
MLK
S
E
N
K
T
T
----
-
-
-----
GDRL
S
II
PEY
TLN
S
TLSW
QA
RE
D
L
S
M
Q
TTF
T
W
YG
KQQ
P
KKY
-
N
Y
KG
QPAVG
P
ETKEIS
P
-
Y
SIV
G
L
S
AT
W
D
VTKN
V
S
LTGG
VDNLFD
K
R
L
WRAGNA
Q
T
T
G
DLA
GANY
I
A
GA
G
AYT
Y
N
-
E
PG
--
RT
WY
M
SI
NTHF
fig|749528.3.peg.4054
Escherichia coli MS 45-1
MNKKIHSL
A
LLVNL
G
IYGVA
--
-
Q
A
Q
EP
TD
TPVSH
DDT
I
VVTA
-
A
E
Q
N
L
-
Q
AP
GV
S
---
-------------
T
I
T
A
DEIR
K
N
P
V
A
R
DVS
E
II
R
T
MPGVN
L
---
--
TGNST
S
G
Q
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
K
P
VS
S
R
NSV
RQGW
RGE
RDT
RG
DTSWVPPEM
I
E
R
I
EVLRGP
A
AA
R
YG
N
G
A
A
GG
V
V
NIITK
KG
SGEWH
G
SW
D
A
Y
F
NA
PE
H
KEEGATK
R
TN
FSLTGP
L
-
GD
EFSF
RLYG
NLD
--
KT
Q
A
D
AWD
IN
Q
--
G
HQSAR
AGTYATTLP
AGR
EG
V
I
N
K
DINGV
VR
WDF
AP
LQ
S
LELEA
G
YSRQGN
L
-
Y
AGD
TQ
NTNS
D
---------------
AY
T
RS
--
KY
G
D
-
E
T
NRL
Y
RQ
NY
S
LTWN
GG
WD
N
G
V
T
T
S
NWVQY
EH
-----------
TR
N
SR
IP
E
-
----
G
LA
G
-----
G
TEGKFNEK
A
AQDFVDI
D
L
D
D
V
M
L
H
SEV
N
-
-
-
LPIDF
L
V
--
NQT
----
--
--
--
--
--
LT
L
G
T
EWNQQ
R
M
KDLSS
N
TQA
L
TGT
N
T
---
GGA
I
--
D
G
V
S
A
TD
------------------
R
S
P
Y
SK
AE
I
F
S
L
F
A
EN
N
ME
LTD
S
T
I
V
T
P
GLRFD
H
H
SIVGN
N
WS
PALNISQGL
GD
D
-
---F
T
LKM
G
I
A
RA
----------------
Y
KA
P
S
LY
Q
TN
P
N
--
-
YI
L
Y
S
----
-
K
G
Q
G
CY
A
--
S
AG
GCYLQGND
D
L
KAE
T
SIN
K
EIG
L
EFK
RD
G
-
-
W
L
AG
V
T
W
FR
N
D
YR
NKIE
A
G
Y
V
AV
G
QN
AV
GT
DLYQ
W
D
N
V
P
KA
V
VEG
L
E
G
S
LN---V
P
-
VSE
TVM
W
TN
N
I
T
Y
MLK
S
E
N
K
T
T
----
-
-
-----
GDRL
S
II
PEY
TLN
S
TLSW
QA
RE
D
L
S
M
Q
TTF
T
W
YG
KQQ
P
KKY
-
N
Y
KG
QPAVG
P
ETKEIS
P
-
Y
SIV
G
L
S
AT
W
D
VTKN
V
S
LTGG
VDNLFD
K
R
L
WRAGNA
Q
T
T
G
DLA
GANY
I
A
GA
G
AYT
Y
N
-
E
PG
--
RT
WY
M
SI
NTHF
fig|574521.7.peg.521
Escherichia coli O127:H6 str. E2348/69
MNKKIHSL
A
LLVNL
G
IYGVA
--
-
Q
A
Q
EP
TD
TPVSH
DDT
I
VVTA
-
A
E
Q
N
L
-
Q
AP
GV
S
---
-------------
T
I
T
A
DEIR
K
N
P
V
A
R
DVS
E
II
R
T
MPGVN
L
---
--
TGNST
S
G
Q
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
K
P
VS
S
R
NSV
RQGW
RGE
RDT
RG
DTSWVPPEM
I
E
R
I
EVLRGP
A
AA
R
YG
N
G
A
A
GG
V
V
NIITK
KG
SGEWH
G
SW
D
A
Y
F
NA
PE
H
KEEGATK
R
TN
FSLTGP
L
-
GD
EFSF
RLYG
NLD
--
KT
Q
A
D
AWD
IN
Q
--
G
HQSAR
AGTYATTLP
AGR
EG
V
I
N
K
DINGV
VR
WDF
AP
LQ
S
LELEA
G
YSRQGN
L
-
Y
AGD
TQ
NTNS
D
---------------
AY
T
RS
--
KY
G
D
-
E
T
NRL
Y
RQ
NY
S
LTWN
GG
WD
N
G
V
T
T
S
NWVQY
EH
-----------
TR
N
SR
IP
E
-
----
G
LA
G
-----
G
TEGKFNEK
A
AQDFVDI
D
L
D
D
V
M
L
H
SEV
N
-
-
-
LPIDF
L
V
--
NQT
----
--
--
--
--
--
LT
L
G
T
EWNQQ
R
M
KDLSS
N
TQA
L
TGT
N
T
---
GGA
I
--
D
G
V
S
A
TD
------------------
R
S
P
Y
SK
AE
I
F
S
L
F
A
EN
N
ME
LTD
S
T
I
V
T
P
GLRFD
H
H
SIVGN
N
WS
PALNISQGL
GD
D
-
---F
T
LKM
G
I
A
RA
----------------
Y
KA
P
S
LY
Q
TN
P
N
--
-
YI
L
Y
S
----
-
K
G
Q
G
CY
A
--
S
AG
GCYLQGND
D
L
KAE
T
SIN
K
EIG
L
EFK
RD
G
-
-
W
L
AG
V
T
W
FR
N
D
YR
NKIE
A
G
Y
V
AV
G
QN
AV
GT
DLYQ
W
D
N
V
P
KA
V
VEG
L
E
G
S
LN---V
P
-
VSE
TVM
W
TN
N
I
T
Y
MLK
S
E
N
K
T
T
----
-
-
-----
GDRL
S
II
PEY
TLN
S
TLSW
QA
RE
D
L
S
M
Q
TTF
T
W
YG
KQQ
P
KKY
-
N
Y
KG
QPAVG
P
ETKEIS
P
-
Y
SIV
G
L
S
AT
W
D
VTKN
V
S
LTGG
VDNLFD
K
R
L
WRAGNA
Q
T
T
G
DLA
GANY
I
A
GA
G
AYT
Y
N
-
E
PG
--
RT
WY
M
SI
NTHF
fig|656440.3.peg.439
Escherichia coli TA206
MNKKIHSL
A
LLVNL
G
IYGVA
--
-
Q
A
Q
EP
TD
TPVSH
DDT
I
VVTA
-
A
E
Q
N
L
-
Q
AP
GV
S
---
-------------
T
I
T
A
DEIR
K
N
P
V
A
R
DVS
E
II
R
T
MPGVN
L
---
--
TGNST
S
G
Q
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
K
P
VS
S
R
NSV
RQGW
RGE
RDT
RG
DTSWVPPEM
I
E
R
I
EVLRGP
A
AA
R
YG
N
G
A
A
GG
V
V
NIITK
KG
SGEWH
G
SW
D
A
Y
F
NA
PE
H
KEEGATK
R
TN
FSLTGP
L
-
GD
EFSF
RLYG
NLD
--
KT
Q
A
D
AWD
IN
Q
--
G
HQSAR
AGTYATTLP
AGR
EG
V
I
N
K
DINGV
VR
WDF
AP
LQ
S
LELEA
G
YSRQGN
L
-
Y
AGD
TQ
NTNS
D
---------------
AY
T
RS
--
KY
G
D
-
E
T
NRL
Y
RQ
NY
S
LTWN
GG
WD
N
G
V
T
T
S
NWVQY
EH
-----------
TR
N
SR
IP
E
-
----
G
LA
G
-----
G
TEGKFNEK
A
AQDFVDI
D
L
D
D
V
M
L
H
SEV
N
-
-
-
LPIDF
L
V
--
NQT
----
--
--
--
--
--
LT
L
G
T
EWNQQ
R
M
KDLSS
N
TQA
L
TGT
N
T
---
GGA
I
--
D
G
V
S
A
TD
------------------
R
S
P
Y
SK
AE
I
F
S
L
F
A
EN
N
ME
LTD
S
T
I
V
T
P
GLRFD
H
H
SIVGN
N
WS
PALNISQGL
GD
D
-
---F
T
LKM
G
I
A
RA
----------------
Y
KA
P
S
LY
Q
TN
P
N
--
-
YI
L
Y
S
----
-
K
G
Q
G
CY
A
--
S
AG
GCYLQGND
D
L
KAE
T
SIN
K
EIG
L
EFK
RD
G
-
-
W
L
AG
V
T
W
FR
N
D
YR
NKIE
A
G
Y
V
AV
G
QN
AV
GT
DLYQ
W
D
N
V
P
KA
V
VEG
L
E
G
S
LN---V
P
-
VSE
TVM
W
TN
N
I
T
Y
MLK
S
E
N
K
T
T
----
-
-
-----
GDRL
S
II
PEY
TLN
S
TLSW
QA
RE
D
L
S
M
Q
TTF
T
W
YG
KQQ
P
KKY
-
N
Y
KG
QPAVG
P
ETKEIS
P
-
Y
SIV
G
L
S
AT
W
D
VTKN
V
S
LTGG
VDNLFD
K
R
L
WRAGNA
Q
T
T
G
DLA
GANY
I
A
GA
G
AYT
Y
N
-
E
PG
--
RT
WY
M
SI
NTHF
fig|869729.3.peg.3122
Escherichia coli UM146
MNKKIHSL
A
LLVNL
G
IYGVA
--
-
Q
A
Q
EP
TD
TPVSH
DDT
I
VVTA
-
A
E
Q
N
L
-
Q
AP
GV
S
---
-------------
T
I
T
A
DEIR
K
N
P
V
A
R
DVS
E
II
R
T
MPGVN
L
---
--
TGNST
S
G
Q
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
K
P
VS
S
R
NSV
RQGW
RGE
RDT
RG
DTSWVPPEM
I
E
R
I
EVLRGP
A
AA
R
YG
N
G
A
A
GG
V
V
NIITK
KG
SGEWH
G
SW
D
A
Y
F
NA
PE
H
KEEGATK
R
TN
FSLTGP
L
-
GD
EFSF
RLYG
NLD
--
KT
Q
A
D
AWD
IN
Q
--
G
HQSAR
AGTYATTLP
AGR
EG
V
I
N
K
DINGV
VR
WDF
AP
LQ
S
LELEA
G
YSRQGN
L
-
Y
AGD
TQ
NTNS
D
---------------
AY
T
RS
--
KY
G
D
-
E
T
NRL
Y
RQ
NY
S
LTWN
GG
WD
N
G
V
T
T
S
NWVQY
EH
-----------
TR
N
SR
IP
E
-
----
G
LA
G
-----
G
TEGKFNEK
A
AQDFVDI
D
L
D
D
V
M
L
H
SEV
N
-
-
-
LPIDF
L
V
--
NQT
----
--
--
--
--
--
LT
L
G
T
EWNQQ
R
M
KDLSS
N
TQA
L
TGT
N
T
---
GGA
I
--
D
G
V
S
A
TD
------------------
R
S
P
Y
SK
AE
I
F
S
L
F
A
EN
N
ME
LTD
S
T
I
V
T
P
GLRFD
H
H
SIVGN
N
WS
PALNISQGL
GD
D
-
---F
T
LKM
G
I
A
RA
----------------
Y
KA
P
S
LY
Q
TN
P
N
--
-
YI
L
Y
S
----
-
K
G
Q
G
CY
A
--
S
AG
GCYLQGND
D
L
KAE
T
SIN
K
EIG
L
EFK
RD
G
-
-
W
L
AG
V
T
W
FR
N
D
YR
NKIE
A
G
Y
V
AV
G
QN
AV
GT
DLYQ
W
D
N
V
P
KA
V
VEG
L
E
G
S
LN---V
P
-
VSE
TVM
W
TN
N
I
T
Y
MLK
S
E
N
K
T
T
----
-
-
-----
GDRL
S
II
PEY
TLN
S
TLSW
QA
RE
D
L
S
M
Q
TTF
T
W
YG
KQQ
P
KKY
-
N
Y
KG
QPAVG
P
ETKEIS
P
-
Y
SIV
G
L
S
AT
W
D
VTKN
V
S
LTGG
VDNLFD
K
R
L
WRAGNA
Q
T
T
G
DLA
GANY
I
A
GA
G
AYT
Y
N
-
E
PG
--
RT
WY
M
SI
NTHF
fig|364106.7.peg.690
Escherichia coli UTI89
MNKKIHSL
A
LLVNL
G
IYGVA
--
-
Q
A
Q
EP
TD
TPVSH
DDT
I
VVTA
-
A
E
Q
N
L
-
Q
AP
GV
S
---
-------------
T
I
T
A
DEIR
K
N
P
V
A
R
DVS
E
II
R
T
MPGVN
L
---
--
TGNST
S
G
Q
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
K
P
VS
S
R
NSV
RQGW
RGE
RDT
RG
DTSWVPPEM
I
E
R
I
EVLRGP
A
AA
R
YG
N
G
A
A
GG
V
V
NIITK
KG
SGEWH
G
SW
D
A
Y
F
NA
PE
H
KEEGATK
R
TN
FSLTGP
L
-
GD
EFSF
RLYG
NLD
--
KT
Q
A
D
AWD
IN
Q
--
G
HQSAR
AGTYATTLP
AGR
EG
V
I
N
K
DINGV
VR
WDF
AP
LQ
S
LELEA
G
YSRQGN
L
-
Y
AGD
TQ
NTNS
D
---------------
AY
T
RS
--
KY
G
D
-
E
T
NRL
Y
RQ
NY
S
LTWN
GG
WD
N
G
V
T
T
S
NWVQY
EH
-----------
TR
N
SR
IP
E
-
----
G
LA
G
-----
G
TEGKFNEK
A
AQDFVDI
D
L
D
D
V
M
L
H
SEV
N
-
-
-
LPIDF
L
V
--
NQT
----
--
--
--
--
--
LT
L
G
T
EWNQQ
R
M
KDLSS
N
TQA
L
TGT
N
T
---
GGA
I
--
D
G
V
S
A
TD
------------------
R
S
P
Y
SK
AE
I
F
S
L
F
A
EN
N
ME
LTD
S
T
I
V
T
P
GLRFD
H
H
SIVGN
N
WS
PALNISQGL
GD
D
-
---F
T
LKM
G
I
A
RA
----------------
Y
KA
P
S
LY
Q
TN
P
N
--
-
YI
L
Y
S
----
-
K
G
Q
G
CY
A
--
S
AG
GCYLQGND
D
L
KAE
T
SIN
K
EIG
L
EFK
RD
G
-
-
W
L
AG
V
T
W
FR
N
D
YR
NKIE
A
G
Y
V
AV
G
QN
AV
GT
DLYQ
W
D
N
V
P
KA
V
VEG
L
E
G
S
LN---V
P
-
VSE
TVM
W
TN
N
I
T
Y
MLK
S
E
N
K
T
T
----
-
-
-----
GDRL
S
II
PEY
TLN
S
TLSW
QA
RE
D
L
S
M
Q
TTF
T
W
YG
KQQ
P
KKY
-
N
Y
KG
QPAVG
P
ETKEIS
P
-
Y
SIV
G
L
S
AT
W
D
VTKN
V
S
LTGG
VDNLFD
K
R
L
WRAGNA
Q
T
T
G
DLA
GANY
I
A
GA
G
AYT
Y
N
-
E
PG
--
RT
WY
M
SI
NTHF
fig|364106.8.peg.688
Escherichia coli UTI89
MNKKIHSL
A
LLVNL
G
IYGVA
--
-
Q
A
Q
EP
TD
TPVSH
DDT
I
VVTA
-
A
E
Q
N
L
-
Q
AP
GV
S
---
-------------
T
I
T
A
DEIR
K
N
P
V
A
R
DVS
E
II
R
T
MPGVN
L
---
--
TGNST
S
G
Q
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
K
P
VS
S
R
NSV
RQGW
RGE
RDT
RG
DTSWVPPEM
I
E
R
I
EVLRGP
A
AA
R
YG
N
G
A
A
GG
V
V
NIITK
KG
SGEWH
G
SW
D
A
Y
F
NA
PE
H
KEEGATK
R
TN
FSLTGP
L
-
GD
EFSF
RLYG
NLD
--
KT
Q
A
D
AWD
IN
Q
--
G
HQSAR
AGTYATTLP
AGR
EG
V
I
N
K
DINGV
VR
WDF
AP
LQ
S
LELEA
G
YSRQGN
L
-
Y
AGD
TQ
NTNS
D
---------------
AY
T
RS
--
KY
G
D
-
E
T
NRL
Y
RQ
NY
S
LTWN
GG
WD
N
G
V
T
T
S
NWVQY
EH
-----------
TR
N
SR
IP
E
-
----
G
LA
G
-----
G
TEGKFNEK
A
AQDFVDI
D
L
D
D
V
M
L
H
SEV
N
-
-
-
LPIDF
L
V
--
NQT
----
--
--
--
--
--
LT
L
G
T
EWNQQ
R
M
KDLSS
N
TQA
L
TGT
N
T
---
GGA
I
--
D
G
V
S
A
TD
------------------
R
S
P
Y
SK
AE
I
F
S
L
F
A
EN
N
ME
LTD
S
T
I
V
T
P
GLRFD
H
H
SIVGN
N
WS
PALNISQGL
GD
D
-
---F
T
LKM
G
I
A
RA
----------------
Y
KA
P
S
LY
Q
TN
P
N
--
-
YI
L
Y
S
----
-
K
G
Q
G
CY
A
--
S
AG
GCYLQGND
D
L
KAE
T
SIN
K
EIG
L
EFK
RD
G
-
-
W
L
AG
V
T
W
FR
N
D
YR
NKIE
A
G
Y
V
AV
G
QN
AV
GT
DLYQ
W
D
N
V
P
KA
V
VEG
L
E
G
S
LN---V
P
-
VSE
TVM
W
TN
N
I
T
Y
MLK
S
E
N
K
T
T
----
-
-
-----
GDRL
S
II
PEY
TLN
S
TLSW
QA
RE
D
L
S
M
Q
TTF
T
W
YG
KQQ
P
KKY
-
N
Y
KG
QPAVG
P
ETKEIS
P
-
Y
SIV
G
L
S
AT
W
D
VTKN
V
S
LTGG
VDNLFD
K
R
L
WRAGNA
Q
T
T
G
DLA
GANY
I
A
GA
G
AYT
Y
N
-
E
PG
--
RT
WY
M
SI
NTHF
fig|562.376.peg.2032
Escherichia coli WV_060327
MNKKIHSL
A
LLVNL
G
IYGVA
--
-
Q
A
Q
EP
TD
TPVSH
DDT
I
VVTA
-
A
E
Q
N
L
-
Q
AP
GV
S
---
-------------
T
I
T
A
DEIR
K
N
P
V
A
R
DVS
E
II
R
T
MPGVN
L
---
--
TGNST
S
G
Q
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
K
P
VS
S
R
NSV
RQGW
RGE
RDT
RG
DTSWVPPEM
I
E
R
I
EVLRGP
A
AA
R
YG
N
G
A
A
GG
V
V
NIITK
KG
SGEWH
G
SW
D
A
Y
F
NA
PE
H
KEEGATK
R
TN
FSLTGP
L
-
GD
EFSF
RLYG
NLD
--
KT
Q
A
D
AWD
IN
Q
--
G
HQSAR
AGTYATTLP
AGR
EG
V
I
N
K
DINGV
VR
WDF
AP
LQ
S
LELEA
G
YSRQGN
L
-
Y
AGD
TQ
NTNS
D
---------------
AY
T
RS
--
KY
G
D
-
E
T
NRL
Y
RQ
NY
S
LTWN
GG
WD
N
G
V
T
T
S
NWVQY
EH
-----------
TR
N
SR
IP
E
-
----
G
LA
G
-----
G
TEGKFNEK
A
AQDFVDI
D
L
D
D
V
M
L
H
SEV
N
-
-
-
LPIDF
L
V
--
NQT
----
--
--
--
--
--
LT
L
G
T
EWNQQ
R
M
KDLSS
N
TQA
L
TGT
N
T
---
GGA
I
--
D
G
V
S
A
TD
------------------
R
S
P
Y
SK
AE
I
F
S
L
F
A
EN
N
ME
LTD
S
T
I
V
T
P
GLRFD
H
H
SIVGN
N
WS
PALNISQGL
GD
D
-
---F
T
LKM
G
I
A
RA
----------------
Y
KA
P
S
LY
Q
TN
P
N
--
-
YI
L
Y
S
----
-
K
G
Q
G
CY
A
--
S
AG
GCYLQGND
D
L
KAE
T
SIN
K
EIG
L
EFK
RD
G
-
-
W
L
AG
V
T
W
FR
N
D
YR
NKIE
A
G
Y
V
AV
G
QN
AV
GT
DLYQ
W
D
N
V
P
KA
V
VEG
L
E
G
S
LN---V
P
-
VSE
TVM
W
TN
N
I
T
Y
MLK
S
E
N
K
T
T
----
-
-
-----
GDRL
S
II
PEY
TLN
S
TLSW
QA
RE
D
L
S
M
Q
TTF
T
W
YG
KQQ
P
KKY
-
N
Y
KG
QPAVG
P
ETKEIS
P
-
Y
SIV
G
L
S
AT
W
D
VTKN
V
S
LTGG
VDNLFD
K
R
L
WRAGNA
Q
T
T
G
DLA
GANY
I
A
GA
G
AYT
Y
N
-
E
PG
--
RT
WY
M
SI
NTHF
fig|216592.1.peg.338
Escherichia coli 042
MNKKIHSL
A
LLVNL
G
IYGVA
--
-
Q
A
Q
EP
TD
TPVSH
DDT
I
VVTA
-
A
E
Q
N
L
-
Q
AP
GV
S
---
-------------
T
I
T
A
DEIR
K
N
P
V
A
R
DVS
E
II
R
T
MPGVN
L
---
--
TGNST
S
G
Q
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
K
P
VS
S
R
NSV
RQGW
RGE
RDT
RG
DTSWVPPEM
I
E
R
I
EVLRGP
A
AA
R
YG
N
G
A
A
GG
V
V
NIITK
KG
SGEWH
G
SW
D
A
Y
F
NA
PE
H
KEEGATK
R
TN
FSLTGP
L
-
GD
EFSF
RLYG
NLD
--
KT
Q
A
D
AWD
IN
Q
--
G
HQSAR
AGTYATTLP
AGR
EG
V
I
N
K
DINGV
VR
WDF
AP
LQ
S
LELEA
G
YSRQGN
L
-
Y
AGD
TQ
NTNS
D
---------------
SY
T
RS
--
KY
G
D
-
E
T
NRL
Y
RQ
NY
S
LTWN
GG
WD
N
G
V
T
T
S
NWVQY
EH
-----------
TR
N
SR
IP
E
-
----
G
LA
G
-----
G
TEGKFNEK
A
TQDFVDI
D
L
D
D
V
M
L
H
SEV
N
-
-
-
LPIDF
L
V
--
NQT
----
--
--
--
--
--
LT
L
G
T
EWNQQ
R
M
KDLSS
N
TQA
L
TGT
N
T
---
GGA
I
--
D
G
V
S
A
TD
------------------
R
S
P
Y
SK
AE
I
F
S
L
F
A
EN
N
ME
LTD
S
T
I
V
T
P
GLRFD
H
H
SIVGN
N
WS
PALNISQGL
GD
D
-
---F
T
LKM
G
I
A
RA
----------------
Y
KA
P
S
LY
Q
TN
P
N
--
-
YI
L
Y
S
----
-
K
G
Q
G
CY
A
--
S
AG
GCYLQGND
D
L
KAE
T
SIN
K
EIG
L
EFK
RD
G
-
-
W
L
AG
V
T
W
FR
N
D
YR
NKIE
A
G
Y
V
AV
G
QN
AV
GT
DLYQ
W
D
N
V
P
KA
V
VEG
L
E
G
S
LN---V
P
-
VSE
TVM
W
TN
N
I
T
Y
MLK
S
E
N
K
T
T
----
-
-
-----
GDRL
S
II
PEY
TLN
S
TLSW
QA
RE
D
L
S
M
Q
TTF
T
W
YG
KQQ
P
KKY
-
N
Y
KG
QPAVG
P
ETKEIS
P
-
Y
SIV
G
L
S
AT
W
D
VTKN
V
S
LTGG
VDNLFD
K
R
L
WRAGNA
Q
T
T
G
DLA
GANY
I
A
GA
G
AYT
Y
N
-
E
PG
--
RT
WY
M
SI
NTHF
fig|216592.3.peg.646
Escherichia coli 042
MNKKIHSL
A
LLVNL
G
IYGVA
--
-
Q
A
Q
EP
TD
TPVSH
DDT
I
VVTA
-
A
E
Q
N
L
-
Q
AP
GV
S
---
-------------
T
I
T
A
DEIR
K
N
P
V
A
R
DVS
E
II
R
T
MPGVN
L
---
--
TGNST
S
G
Q
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
K
P
VS
S
R
NSV
RQGW
RGE
RDT
RG
DTSWVPPEM
I
E
R
I
EVLRGP
A
AA
R
YG
N
G
A
A
GG
V
V
NIITK
KG
SGEWH
G
SW
D
A
Y
F
NA
PE
H
KEEGATK
R
TN
FSLTGP
L
-
GD
EFSF
RLYG
NLD
--
KT
Q
A
D
AWD
IN
Q
--
G
HQSAR
AGTYATTLP
AGR
EG
V
I
N
K
DINGV
VR
WDF
AP
LQ
S
LELEA
G
YSRQGN
L
-
Y
AGD
TQ
NTNS
D
---------------
SY
T
RS
--
KY
G
D
-
E
T
NRL
Y
RQ
NY
S
LTWN
GG
WD
N
G
V
T
T
S
NWVQY
EH
-----------
TR
N
SR
IP
E
-
----
G
LA
G
-----
G
TEGKFNEK
A
TQDFVDI
D
L
D
D
V
M
L
H
SEV
N
-
-
-
LPIDF
L
V
--
NQT
----
--
--
--
--
--
LT
L
G
T
EWNQQ
R
M
KDLSS
N
TQA
L
TGT
N
T
---
GGA
I
--
D
G
V
S
A
TD
------------------
R
S
P
Y
SK
AE
I
F
S
L
F
A
EN
N
ME
LTD
S
T
I
V
T
P
GLRFD
H
H
SIVGN
N
WS
PALNISQGL
GD
D
-
---F
T
LKM
G
I
A
RA
----------------
Y
KA
P
S
LY
Q
TN
P
N
--
-
YI
L
Y
S
----
-
K
G
Q
G
CY
A
--
S
AG
GCYLQGND
D
L
KAE
T
SIN
K
EIG
L
EFK
RD
G
-
-
W
L
AG
V
T
W
FR
N
D
YR
NKIE
A
G
Y
V
AV
G
QN
AV
GT
DLYQ
W
D
N
V
P
KA
V
VEG
L
E
G
S
LN---V
P
-
VSE
TVM
W
TN
N
I
T
Y
MLK
S
E
N
K
T
T
----
-
-
-----
GDRL
S
II
PEY
TLN
S
TLSW
QA
RE
D
L
S
M
Q
TTF
T
W
YG
KQQ
P
KKY
-
N
Y
KG
QPAVG
P
ETKEIS
P
-
Y
SIV
G
L
S
AT
W
D
VTKN
V
S
LTGG
VDNLFD
K
R
L
WRAGNA
Q
T
T
G
DLA
GANY
I
A
GA
G
AYT
Y
N
-
E
PG
--
RT
WY
M
SI
NTHF
fig|656379.3.peg.1364
Escherichia coli FVEC1302
MNKKIHSL
A
LLVNL
G
IYGVA
--
-
Q
A
Q
EP
TD
TPVSH
DDT
I
VVTA
-
A
E
Q
N
L
-
Q
AP
GV
S
---
-------------
T
I
T
A
DEIR
K
N
P
V
A
R
DVS
E
II
R
T
MPGVN
L
---
--
TGNST
S
G
Q
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
K
P
VS
S
R
NSV
RQGW
RGE
RDT
RG
DTSWVPPEM
I
E
R
I
EVLRGP
A
AA
R
YG
N
G
A
A
GG
V
V
NIITK
KG
SGEWH
G
SW
D
A
Y
F
NA
PE
H
KEEGATK
R
TN
FSLTGP
L
-
GD
EFSF
RLYG
NLD
--
KT
Q
A
D
AWD
IN
Q
--
G
HQSAR
AGTYATTLP
AGR
EG
V
I
N
K
DINGV
VR
WDF
AP
LQ
S
LELEA
G
YSRQGN
L
-
Y
AGD
TQ
NTNS
D
---------------
SY
T
RS
--
KY
G
D
-
E
T
NRL
Y
RQ
NY
S
LTWN
GG
WD
N
G
V
T
T
S
NWVQY
EH
-----------
TR
N
SR
IP
E
-
----
G
LA
G
-----
G
TEGKFNEK
A
TQDFVDI
D
L
D
D
V
M
L
H
SEV
N
-
-
-
LPIDF
L
V
--
NQT
----
--
--
--
--
--
LT
L
G
T
EWNQQ
R
M
KDLSS
N
TQA
L
TGT
N
T
---
GGA
I
--
D
G
V
S
A
TD
------------------
R
S
P
Y
SK
AE
I
F
S
L
F
A
EN
N
ME
LTD
S
T
I
V
T
P
GLRFD
H
H
SIVGN
N
WS
PALNISQGL
GD
D
-
---F
T
LKM
G
I
A
RA
----------------
Y
KA
P
S
LY
Q
TN
P
N
--
-
YI
L
Y
S
----
-
K
G
Q
G
CY
A
--
S
AG
GCYLQGND
D
L
KAE
T
SIN
K
EIG
L
EFK
RD
G
-
-
W
L
AG
V
T
W
FR
N
D
YR
NKIE
A
G
Y
V
AV
G
QN
AV
GT
DLYQ
W
D
N
V
P
KA
V
VEG
L
E
G
S
LN---V
P
-
VSE
TVM
W
TN
N
I
T
Y
MLK
S
E
N
K
T
T
----
-
-
-----
GDRL
S
II
PEY
TLN
S
TLSW
QA
RE
D
L
S
M
Q
TTF
T
W
YG
KQQ
P
KKY
-
N
Y
KG
QPAVG
P
ETKEIS
P
-
Y
SIV
G
L
S
AT
W
D
VTKN
V
S
LTGG
VDNLFD
K
R
L
WRAGNA
Q
T
T
G
DLA
GANY
I
A
GA
G
AYT
Y
N
-
E
PG
--
RT
WY
M
SI
NTHF
fig|656380.3.peg.1192
Escherichia coli FVEC1412
MNKKIHSL
A
LLVNL
G
IYGVA
--
-
Q
A
Q
EP
TD
TPVSH
DDT
I
VVTA
-
A
E
Q
N
L
-
Q
AP
GV
S
---
-------------
T
I
T
A
DEIR
K
N
P
V
A
R
DVS
E
II
R
T
MPGVN
L
---
--
TGNST
S
G
Q
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
K
P
VS
S
R
NSV
RQGW
RGE
RDT
RG
DTSWVPPEM
I
E
R
I
EVLRGP
A
AA
R
YG
N
G
A
A
GG
V
V
NIITK
KG
SGEWH
G
SW
D
A
Y
F
NA
PE
H
KEEGATK
R
TN
FSLTGP
L
-
GD
EFSF
RLYG
NLD
--
KT
Q
A
D
AWD
IN
Q
--
G
HQSAR
AGTYATTLP
AGR
EG
V
I
N
K
DINGV
VR
WDF
AP
LQ
S
LELEA
G
YSRQGN
L
-
Y
AGD
TQ
NTNS
D
---------------
SY
T
RS
--
KY
G
D
-
E
T
NRL
Y
RQ
NY
S
LTWN
GG
WD
N
G
V
T
T
S
NWVQY
EH
-----------
TR
N
SR
IP
E
-
----
G
LA
G
-----
G
TEGKFNEK
A
TQDFVDI
D
L
D
D
V
M
L
H
SEV
N
-
-
-
LPIDF
L
V
--
NQT
----
--
--
--
--
--
LT
L
G
T
EWNQQ
R
M
KDLSS
N
TQA
L
TGT
N
T
---
GGA
I
--
D
G
V
S
A
TD
------------------
R
S
P
Y
SK
AE
I
F
S
L
F
A
EN
N
ME
LTD
S
T
I
V
T
P
GLRFD
H
H
SIVGN
N
WS
PALNISQGL
GD
D
-
---F
T
LKM
G
I
A
RA
----------------
Y
KA
P
S
LY
Q
TN
P
N
--
-
YI
L
Y
S
----
-
K
G
Q
G
CY
A
--
S
AG
GCYLQGND
D
L
KAE
T
SIN
K
EIG
L
EFK
RD
G
-
-
W
L
AG
V
T
W
FR
N
D
YR
NKIE
A
G
Y
V
AV
G
QN
AV
GT
DLYQ
W
D
N
V
P
KA
V
VEG
L
E
G
S
LN---V
P
-
VSE
TVM
W
TN
N
I
T
Y
MLK
S
E
N
K
T
T
----
-
-
-----
GDRL
S
II
PEY
TLN
S
TLSW
QA
RE
D
L
S
M
Q
TTF
T
W
YG
KQQ
P
KKY
-
N
Y
KG
QPAVG
P
ETKEIS
P
-
Y
SIV
G
L
S
AT
W
D
VTKN
V
S
LTGG
VDNLFD
K
R
L
WRAGNA
Q
T
T
G
DLA
GANY
I
A
GA
G
AYT
Y
N
-
E
PG
--
RT
WY
M
SI
NTHF
fig|656393.3.peg.1259
Escherichia coli H299
MNKKIHSL
A
LLVNL
G
IYGVA
--
-
Q
A
Q
EP
TD
TPVSH
DDT
I
VVTA
-
A
E
Q
N
L
-
Q
AP
GV
S
---
-------------
T
I
T
A
DEIR
K
N
P
V
A
R
DVS
E
II
R
T
MPGVN
L
---
--
TGNST
S
G
Q
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
K
P
VS
S
R
NSV
RQGW
RGE
RDT
RG
DTSWVPPEM
I
E
R
I
EVLRGP
A
AA
R
YG
N
G
A
A
GG
V
V
NIITK
KG
SGEWH
G
SW
D
A
Y
F
NA
PE
H
KEEGATK
R
TN
FSLTGP
L
-
GD
EFSF
RLYG
NLD
--
KT
Q
A
D
AWD
IN
Q
--
G
HQSAR
AGTYATTLP
AGR
EG
V
I
N
K
DINGV
VR
WDF
AP
LQ
S
LELEA
G
YSRQGN
L
-
Y
AGD
TQ
NTNS
D
---------------
SY
T
RS
--
KY
G
D
-
E
T
NRL
Y
RQ
NY
S
LTWN
GG
WD
N
G
V
T
T
S
NWVQY
EH
-----------
TR
N
SR
IP
E
-
----
G
LA
G
-----
G
TEGKFNEK
A
TQDFVDI
D
L
D
D
V
M
L
H
SEV
N
-
-
-
LPIDF
L
V
--
NQT
----
--
--
--
--
--
LT
L
G
T
EWNQQ
R
M
KDLSS
N
TQA
L
TGT
N
T
---
GGA
I
--
D
G
V
S
A
TD
------------------
R
S
P
Y
SK
AE
I
F
S
L
F
A
EN
N
ME
LTD
S
T
I
V
T
P
GLRFD
H
H
SIVGN
N
WS
PALNISQGL
GD
D
-
---F
T
LKM
G
I
A
RA
----------------
Y
KA
P
S
LY
Q
TN
P
N
--
-
YI
L
Y
S
----
-
K
G
Q
G
CY
A
--
S
AG
GCYLQGND
D
L
KAE
T
SIN
K
EIG
L
EFK
RD
G
-
-
W
L
AG
V
T
W
FR
N
D
YR
NKIE
A
G
Y
V
AV
G
QN
AV
GT
DLYQ
W
D
N
V
P
KA
V
VEG
L
E
G
S
LN---V
P
-
VSE
TVM
W
TN
N
I
T
Y
MLK
S
E
N
K
T
T
----
-
-
-----
GDRL
S
II
PEY
TLN
S
TLSW
QA
RE
D
L
S
M
Q
TTF
T
W
YG
KQQ
P
KKY
-
N
Y
KG
QPAVG
P
ETKEIS
P
-
Y
SIV
G
L
S
AT
W
D
VTKN
V
S
LTGG
VDNLFD
K
R
L
WRAGNA
Q
T
T
G
DLA
GANY
I
A
GA
G
AYT
Y
N
-
E
PG
--
RT
WY
M
SI
NTHF
fig|749549.3.peg.4847
Escherichia coli MS 198-1
MNKKIHSL
A
LLVNL
G
IYGVA
--
-
Q
A
Q
EP
TD
TPVSH
DDT
I
VVTA
-
A
E
Q
N
L
-
Q
AP
GV
S
---
-------------
T
I
T
A
DEIR
K
N
P
V
A
R
DVS
E
II
R
T
MPGVN
L
---
--
TGNST
S
G
Q
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
K
P
VS
S
R
NSV
RQGW
RGE
RDT
RG
DTSWVPPEM
I
E
R
I
EVLRGP
A
AA
R
YG
N
G
A
A
GG
V
V
NIITK
KG
SGEWH
G
SW
D
A
Y
F
NA
PE
H
KEEGATK
R
TN
FSLTGP
L
-
GD
EFSF
RLYG
NLD
--
KT
Q
A
D
AWD
IN
Q
--
G
HQSAR
AGTYATTLP
AGR
EG
V
I
N
K
DINGV
VR
WDF
AP
LQ
S
LELEA
G
YSRQGN
L
-
Y
AGD
TQ
NTNS
D
---------------
SY
T
RS
--
KY
G
D
-
E
T
NRL
Y
RQ
NY
S
LTWN
GG
WD
N
G
V
T
T
S
NWVQY
EH
-----------
TR
N
SR
IP
E
-
----
G
LA
G
-----
G
TEGKFNEK
A
TQDFVDI
D
L
D
D
V
M
L
H
SEV
N
-
-
-
LPIDF
L
V
--
NQT
----
--
--
--
--
--
LT
L
G
T
EWNQQ
R
M
KDLSS
N
TQA
L
TGT
N
T
---
GGA
I
--
D
G
V
S
A
TD
------------------
R
S
P
Y
SK
AE
I
F
S
L
F
A
EN
N
ME
LTD
S
T
I
V
T
P
GLRFD
H
H
SIVGN
N
WS
PALNISQGL
GD
D
-
---F
T
LKM
G
I
A
RA
----------------
Y
KA
P
S
LY
Q
TN
P
N
--
-
YI
L
Y
S
----
-
K
G
Q
G
CY
A
--
S
AG
GCYLQGND
D
L
KAE
T
SIN
K
EIG
L
EFK
RD
G
-
-
W
L
AG
V
T
W
FR
N
D
YR
NKIE
A
G
Y
V
AV
G
QN
AV
GT
DLYQ
W
D
N
V
P
KA
V
VEG
L
E
G
S
LN---V
P
-
VSE
TVM
W
TN
N
I
T
Y
MLK
S
E
N
K
T
T
----
-
-
-----
GDRL
S
II
PEY
TLN
S
TLSW
QA
RE
D
L
S
M
Q
TTF
T
W
YG
KQQ
P
KKY
-
N
Y
KG
QPAVG
P
ETKEIS
P
-
Y
SIV
G
L
S
AT
W
D
VTKN
V
S
LTGG
VDNLFD
K
R
L
WRAGNA
Q
T
T
G
DLA
GANY
I
A
GA
G
AYT
Y
N
-
E
PG
--
RT
WY
M
SI
NTHF
fig|656437.3.peg.658
Escherichia coli TA143
MNKKIHSL
A
LLVNL
G
IYGVA
--
-
Q
A
Q
EP
TD
TPVSH
DDT
I
VVTA
-
A
E
Q
N
L
-
Q
AP
GV
S
---
-------------
T
I
T
A
DEIR
K
N
P
V
A
R
DVS
E
II
R
T
MPGVN
L
---
--
TGNST
S
G
Q
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
K
P
VS
S
R
NSV
RQGW
RGE
RDT
RG
DTSWVPPEM
I
E
R
I
EVLRGP
A
AA
R
YG
N
G
A
A
GG
V
V
NIITK
KG
SGEWH
G
SW
D
A
Y
F
NA
PE
H
KEEGATK
R
TN
FSLTGP
L
-
GD
EFSF
RLYG
NLD
--
KT
Q
A
D
AWD
IN
Q
--
G
HQSAR
AGTYATTLP
AGR
EG
V
I
N
K
DINGV
VR
WDF
AP
LQ
S
LELEA
G
YSRQGN
L
-
Y
AGD
TQ
NTNS
D
---------------
SY
T
RS
--
KY
G
D
-
E
T
NRL
Y
RQ
NY
S
LTWN
GG
WD
N
G
V
T
T
S
NWVQY
EH
-----------
TR
N
SR
IP
E
-
----
G
LA
G
-----
G
TEGKFNEK
A
TQDFVDI
D
L
D
D
V
M
L
H
SEV
N
-
-
-
LPIDF
L
V
--
NQT
----
--
--
--
--
--
LT
L
G
T
EWNQQ
R
M
KDLSS
N
TQA
L
TGT
N
T
---
GGA
I
--
D
G
V
S
A
TD
------------------
R
S
P
Y
SK
AE
I
F
S
L
F
A
EN
N
ME
LTD
S
T
I
V
T
P
GLRFD
H
H
SIVGN
N
WS
PALNISQGL
GD
D
-
---F
T
LKM
G
I
A
RA
----------------
Y
KA
P
S
LY
Q
TN
P
N
--
-
YI
L
Y
S
----
-
K
G
Q
G
CY
A
--
S
AG
GCYLQGND
D
L
KAE
T
SIN
K
EIG
L
EFK
RD
G
-
-
W
L
AG
V
T
W
FR
N
D
YR
NKIE
A
G
Y
V
AV
G
QN
AV
GT
DLYQ
W
D
N
V
P
KA
V
VEG
L
E
G
S
LN---V
P
-
VSE
TVM
W
TN
N
I
T
Y
MLK
S
E
N
K
T
T
----
-
-
-----
GDRL
S
II
PEY
TLN
S
TLSW
QA
RE
D
L
S
M
Q
TTF
T
W
YG
KQQ
P
KKY
-
N
Y
KG
QPAVG
P
ETKEIS
P
-
Y
SIV
G
L
S
AT
W
D
VTKN
V
S
LTGG
VDNLFD
K
R
L
WRAGNA
Q
T
T
G
DLA
GANY
I
A
GA
G
AYT
Y
N
-
E
PG
--
RT
WY
M
SI
NTHF
fig|585056.7.peg.873
Escherichia coli UMN026
MNKKIHSL
A
LLVNL
G
IYGVA
--
-
Q
A
Q
EP
TD
TPVSH
DDT
I
VVTA
-
A
E
Q
N
L
-
Q
AP
GV
S
---
-------------
T
I
T
A
DEIR
K
N
P
V
A
R
DVS
E
II
R
T
MPGVN
L
---
--
TGNST
S
G
Q
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
K
P
VS
S
R
NSV
RQGW
RGE
RDT
RG
DTSWVPPEM
I
E
R
I
EVLRGP
A
AA
R
YG
N
G
A
A
GG
V
V
NIITK
KG
SGEWH
G
SW
D
A
Y
F
NA
PE
H
KEEGATK
R
TN
FSLTGP
L
-
GD
EFSF
RLYG
NLD
--
KT
Q
A
D
AWD
IN
Q
--
G
HQSAR
AGTYATTLP
AGR
EG
V
I
N
K
DINGV
VR
WDF
AP
LQ
S
LELEA
G
YSRQGN
L
-
Y
AGD
TQ
NTNS
D
---------------
SY
T
RS
--
KY
G
D
-
E
T
NRL
Y
RQ
NY
S
LTWN
GG
WD
N
G
V
T
T
S
NWVQY
EH
-----------
TR
N
SR
IP
E
-
----
G
LA
G
-----
G
TEGKFNEK
A
TQDFVDI
D
L
D
D
V
M
L
H
SEV
N
-
-
-
LPIDF
L
V
--
NQT
----
--
--
--
--
--
LT
L
G
T
EWNQQ
R
M
KDLSS
N
TQA
L
TGT
N
T
---
GGA
I
--
D
G
V
S
A
TD
------------------
R
S
P
Y
SK
AE
I
F
S
L
F
A
EN
N
ME
LTD
S
T
I
V
T
P
GLRFD
H
H
SIVGN
N
WS
PALNISQGL
GD
D
-
---F
T
LKM
G
I
A
RA
----------------
Y
KA
P
S
LY
Q
TN
P
N
--
-
YI
L
Y
S
----
-
K
G
Q
G
CY
A
--
S
AG
GCYLQGND
D
L
KAE
T
SIN
K
EIG
L
EFK
RD
G
-
-
W
L
AG
V
T
W
FR
N
D
YR
NKIE
A
G
Y
V
AV
G
QN
AV
GT
DLYQ
W
D
N
V
P
KA
V
VEG
L
E
G
S
LN---V
P
-
VSE
TVM
W
TN
N
I
T
Y
MLK
S
E
N
K
T
T
----
-
-
-----
GDRL
S
II
PEY
TLN
S
TLSW
QA
RE
D
L
S
M
Q
TTF
T
W
YG
KQQ
P
KKY
-
N
Y
KG
QPAVG
P
ETKEIS
P
-
Y
SIV
G
L
S
AT
W
D
VTKN
V
S
LTGG
VDNLFD
K
R
L
WRAGNA
Q
T
T
G
DLA
GANY
I
A
GA
G
AYT
Y
N
-
E
PG
--
RT
WY
M
SI
NTHF
fig|749531.3.peg.4123
Escherichia coli MS 69-1
MNKKIHSL
A
LLVNL
G
IYGVA
--
-
Q
A
Q
EP
TD
TPVSH
DDT
I
VVTA
-
A
E
Q
N
L
-
Q
AP
GV
S
---
-------------
T
I
T
A
DEIR
K
N
P
V
A
R
DVS
E
II
R
T
MPGVN
L
---
--
TGNST
S
G
Q
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
K
P
VS
S
R
NSV
RQGW
RGE
RDT
RG
DTSWVPPEM
I
E
R
I
EVLRGP
A
AA
R
YG
N
G
A
A
GG
V
V
NIITK
KG
SGEWH
G
SW
D
A
Y
F
NA
PE
H
KEEGATK
R
TN
FSLTGP
L
-
GD
EFSF
RLYG
NLD
--
KT
Q
A
D
AWD
IN
Q
--
G
HQSAR
AGTYATTLP
AGR
EG
V
I
N
K
DINGV
VR
WDF
AP
LQ
S
LELEA
G
YSRQGN
L
-
Y
AGD
TQ
NTNS
D
---------------
SY
T
RS
--
KY
G
D
-
E
T
NRL
Y
RQ
NY
S
LTWN
GG
WD
N
G
V
T
T
S
NWVQY
EH
-----------
TR
N
SR
IP
E
-
----
G
LA
G
-----
G
TEGKFNEK
A
TQDFVDI
D
L
D
D
V
M
L
H
SEV
N
-
-
-
LPIDF
L
I
--
NQT
----
--
--
--
--
--
LT
L
G
T
EWNQQ
R
M
KDLSS
N
TQA
L
TGT
N
T
---
GGA
I
--
D
G
V
S
A
TD
------------------
R
S
P
Y
SK
AE
I
F
S
L
F
A
EN
N
ME
LTD
S
T
I
V
T
P
GLRFD
H
H
SIVGN
N
WS
PALNISQGL
GD
D
-
---F
T
LKM
G
I
A
RA
----------------
Y
KA
P
S
LY
Q
TN
P
N
--
-
YI
L
Y
S
----
-
K
G
Q
G
CY
A
--
S
AG
GCYLQGND
D
L
KAE
T
SIN
K
EIG
L
EFK
RD
G
-
-
W
L
AG
V
T
W
FR
N
D
YR
NKIE
A
G
Y
V
AV
G
QN
AV
GT
DLYQ
W
D
N
V
P
KA
V
VEG
L
E
G
S
LN---V
P
-
VSE
TVM
W
TN
N
I
T
Y
MLK
S
E
N
K
T
T
----
-
-
-----
GDRL
S
II
PEY
TLN
S
TLSW
QA
RE
D
L
S
M
Q
TTF
T
W
YG
KQQ
P
KKY
-
N
Y
KG
QPAVG
P
ETKEIS
P
-
Y
SIV
G
L
S
AT
W
D
VTKN
V
S
LTGG
VDNLFD
K
R
L
WRAGNA
Q
T
T
G
DLA
GANY
I
A
GA
G
AYT
Y
N
-
E
PG
--
RT
WY
M
SI
NTHF
fig|656417.3.peg.705
Escherichia coli M605
MNKKIHSL
A
LLVNL
G
IYGVA
--
-
Q
A
Q
EP
TD
TPVSH
DDT
I
VVTA
-
A
E
Q
N
L
-
Q
AP
GV
S
---
-------------
T
I
T
A
DEIR
K
N
P
V
A
R
DVS
E
II
R
T
MPGVN
L
---
--
TGNST
S
G
Q
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
K
P
VS
S
R
NSV
RQGW
RGE
RDT
RG
DTSWVPPEM
I
E
R
I
EVLRGP
A
AA
R
YG
N
G
A
A
GG
V
V
NIITK
KG
SGEWH
G
SW
D
A
Y
F
NA
PE
H
KEEGATK
R
TN
FSLTGP
L
-
GD
EFSF
RLYG
NLD
--
KT
Q
A
D
AWD
IN
Q
--
G
HQSAR
AGTYATTLP
AGR
EG
V
I
N
K
DINGV
VR
WDF
AP
LQ
S
LELEA
G
YSRQGN
L
-
Y
AGD
TQ
NTNS
D
---------------
AY
T
RS
--
KY
G
D
-
E
T
NRL
Y
RQ
NY
S
LTWN
GG
WD
N
G
V
T
T
S
NWVQY
EH
-----------
TR
N
SR
IP
E
-
----
G
LA
G
-----
G
TEGKFNEK
A
AQDFVDI
D
L
D
D
V
M
L
H
SEV
N
-
-
-
LPIDF
L
V
--
NQT
----
--
--
--
--
--
LT
L
G
T
EWNQQ
R
M
KDLSS
N
TQA
L
TGT
N
T
---
GGA
I
--
D
G
V
S
A
TD
------------------
R
S
P
Y
SK
AE
I
F
S
L
F
A
EN
N
ME
LTD
S
T
I
V
T
P
GLRFD
H
H
SIVGN
N
WS
PALNISQGL
GD
D
-
---F
T
LKM
G
I
A
RA
----------------
Y
KA
P
S
LY
Q
TN
P
N
--
-
YI
L
Y
S
----
-
K
G
Q
G
CY
A
--
S
AG
GCYLQGND
D
L
KAE
T
SIN
K
EIG
L
EFK
RD
G
-
-
W
L
AG
V
T
W
FR
N
D
YR
NKIE
A
G
Y
V
AV
G
K
N
AV
GT
DLYQ
W
D
N
V
P
KA
V
VEG
L
E
G
S
LN---V
P
-
VSE
TVM
W
TN
N
I
T
Y
MLK
S
E
N
K
T
T
----
-
-
-----
GDRL
S
II
PEY
TLN
S
TLSW
QA
RE
D
L
S
M
Q
TTF
T
W
YG
KQQ
P
KKY
-
N
Y
KG
QPAVG
P
ETKEIS
P
-
Y
SIV
G
L
S
AT
W
D
VTKN
V
S
LTGG
VDNLFD
K
R
L
WRAGNA
Q
T
T
G
DLA
GANY
I
A
GA
G
AYT
Y
N
-
E
PG
--
RT
WY
M
SI
NTHF
fig|431946.3.peg.543
Escherichia coli SE15
MNKKIHSL
A
LLVNL
G
IYGVA
--
-
Q
A
Q
EP
TD
TPVSH
DDT
I
VVTA
-
A
E
Q
N
L
-
Q
AP
GV
S
---
-------------
T
I
T
A
DEIR
K
N
P
V
A
R
DVS
E
II
R
T
MPGVN
L
---
--
TGNST
S
G
Q
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
K
P
VS
S
R
NSV
RQGW
RGE
RDT
RG
DTSWVPPEM
I
E
R
I
EVLRGP
A
AA
R
YG
N
G
A
A
GG
V
V
NIITK
KG
SGEWH
G
SW
D
A
Y
F
NA
PE
H
KEEGATK
R
TN
FSLTGP
L
-
GD
EFSF
RLYG
NLD
--
KT
Q
A
D
AWD
IN
Q
--
G
HQSAR
AGTYATTLP
AGR
EG
V
I
N
K
DINGV
VR
WDF
AP
LQ
S
LELEA
G
YSRQGN
L
-
Y
AGD
TQ
NTNS
D
---------------
AY
T
RS
--
KY
G
D
-
E
T
NRL
Y
RQ
NY
S
LTWN
GG
WD
N
G
V
T
T
S
NWVQY
EH
-----------
TR
N
SR
IP
E
-
----
G
LA
G
-----
G
TEGKFNEK
A
AQDFVDI
D
L
D
D
V
M
L
H
SEV
N
-
-
-
LPIDF
L
V
--
NQT
----
--
--
--
--
--
LT
L
G
T
EWNQQ
R
M
KDLSS
N
TQA
L
TGT
N
T
---
GGA
I
--
D
G
V
S
A
TD
------------------
R
S
P
Y
SK
AE
I
F
S
L
F
A
EN
N
ME
LTD
S
T
I
V
T
P
GLRFD
H
H
SIVGN
N
WS
PALNISQGL
GD
D
-
---F
T
LKM
G
I
A
RA
----------------
Y
KA
P
S
LY
Q
TN
P
N
--
-
YI
L
Y
S
----
-
K
G
Q
G
CY
A
--
S
AG
GCYLQGND
D
L
KAE
T
SIN
K
EIG
L
EFK
RD
G
-
-
W
L
AG
V
T
W
FR
N
D
YR
NKIE
A
G
Y
V
AV
G
K
N
AV
GT
DLYQ
W
D
N
V
P
KA
V
VEG
L
E
G
S
LN---V
P
-
VSE
TVM
W
TN
N
I
T
Y
MLK
S
E
N
K
T
T
----
-
-
-----
GDRL
S
II
PEY
TLN
S
TLSW
QA
RE
D
L
S
M
Q
TTF
T
W
YG
KQQ
P
KKY
-
N
Y
KG
QPAVG
P
ETKEIS
P
-
Y
SIV
G
L
S
AT
W
D
VTKN
V
S
LTGG
VDNLFD
K
R
L
WRAGNA
Q
T
T
G
DLA
GANY
I
A
GA
G
AYT
Y
N
-
E
PG
--
RT
WY
M
SI
NTHF
fig|749546.3.peg.3409
Escherichia coli MS 185-1
MNKKIHSL
A
LLVNL
G
IYGVA
--
-
Q
A
Q
EP
TD
TPVSH
DDT
I
VVTA
-
A
E
Q
N
L
-
Q
AP
GV
S
---
-------------
T
I
T
A
DEIR
K
N
P
V
A
R
DVS
E
II
R
T
MPGVN
L
---
--
TGNST
S
G
Q
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
K
P
VS
S
R
NSV
RQGW
RGE
RDT
RG
DTSWVPPEM
I
E
R
I
EVLRGP
A
AA
R
YG
N
G
A
A
GG
V
V
NIITK
KG
SGEWH
G
SW
D
A
Y
F
NA
PE
H
KEEGATK
R
TN
FSLTGP
L
-
GD
EFSF
RLYG
NLD
--
KT
Q
A
D
AWD
IN
Q
--
G
HQSAR
AGTYATTLP
AGR
EG
V
I
N
K
DINGV
VR
WDF
AP
LQ
S
LELEA
G
YSRQGN
L
-
Y
AGD
TQ
NTNS
D
---------------
AY
T
RS
--
KY
G
D
-
E
T
NRL
Y
RQ
NY
S
LTWN
GG
WD
N
G
V
T
T
S
NWVQY
EH
-----------
TR
N
SR
IP
E
-
----
G
LA
G
-----
G
TEGKFNEK
A
AQDFVDI
D
L
D
D
V
M
L
H
SEV
N
-
-
-
LPIDF
L
V
--
NQT
----
--
--
--
--
--
LT
L
G
T
EWNQQ
R
M
KDLSS
N
TQA
L
TGT
N
T
---
GGA
I
--
D
G
V
S
A
TD
------------------
R
S
P
Y
SK
AE
I
F
S
L
F
A
EN
N
ME
LTD
S
T
I
V
T
P
GLRFD
H
H
SIVGN
N
WS
PALNISQGL
GD
D
-
---F
T
LKM
G
I
A
RA
----------------
Y
KA
P
S
LY
Q
TN
P
N
--
-
YI
L
Y
S
----
-
K
G
Q
G
CY
A
--
S
AG
GCYLQGND
D
L
KAE
T
SIN
K
EIG
L
EFK
RD
G
-
-
W
L
AG
V
T
W
FR
N
D
YR
NKIE
A
G
Y
V
AV
G
QN
AV
GT
DLYQ
W
D
N
V
P
KA
V
VEG
L
E
G
S
LN---V
P
-
VSE
TVM
W
TN
N
I
T
Y
MLK
S
E
N
K
T
T
----
-
-
-----
GDRL
S
II
PEY
TLN
S
TLSW
QA
RE
D
L
S
M
Q
TTF
T
W
YG
KQQ
P
KKY
-
N
Y
KG
QPAVG
P
ETKEIS
P
-
Y
SIV
G
L
S
AT
W
D
VTKN
V
S
LTGG
VDNLFD
K
R
L
WRAGNA
Q
T
T
G
DLA
G
V
NY
I
A
GA
G
AYT
Y
N
-
E
PG
--
RT
WY
M
SI
NTHF
fig|358709.5.peg.1967
Escherichia coli 101-1
MNKKIHSL
A
LLVNL
G
IYGVA
--
-
Q
A
Q
EP
TD
TPVSH
DDT
I
VVTA
-
A
E
Q
N
L
-
Q
AP
GV
S
---
-------------
T
I
T
A
DEIR
K
N
P
V
A
R
DVS
E
II
R
T
MPGVN
L
---
--
TGNST
S
G
Q
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
K
P
VS
S
R
NSV
RQGW
RGE
RDT
RG
DTSWVPPEM
I
E
R
I
EVLRGP
A
AA
R
YG
N
G
A
A
GG
V
V
NIITK
KG
SGEWH
G
SW
D
A
Y
F
NA
PE
H
KEEGATK
R
TN
FSLTGP
L
-
GD
EFSF
RLYG
NLD
--
KT
Q
A
D
AWD
IN
Q
--
G
HQSAR
AGTYATTLP
AGR
EG
V
I
N
K
DINGV
VR
WDF
AP
LQ
S
LELEA
G
YSRQGN
L
-
Y
AGD
TQ
NTNS
D
---------------
SY
T
RS
--
KY
G
D
-
E
T
NRL
Y
RQ
NY
A
LTWN
GG
WD
N
G
V
T
T
S
NWVQY
EH
-----------
TR
N
SR
IP
E
-
----
G
LA
G
-----
G
TEGKFNEK
A
TQDFVDI
D
L
D
D
V
M
L
H
SEV
N
-
-
-
LPIDF
L
V
--
NQT
----
--
--
--
--
--
LT
L
G
T
EWNQQ
R
M
KDLSS
N
TQA
L
TGT
N
T
---
GGA
I
--
D
G
V
S
T
TD
------------------
R
S
P
Y
SK
AE
I
F
S
L
F
A
EN
N
ME
LTD
S
T
I
V
T
P
GLRFD
H
H
SIVGN
N
WS
PALNISQGL
GD
D
-
---F
T
LKM
G
I
A
RA
----------------
Y
KA
P
S
LY
Q
TN
P
N
--
-
YI
L
Y
S
----
-
K
G
Q
G
CY
A
--
S
AG
GCYLQGND
D
L
KAE
T
SIN
K
EIG
L
EFK
RD
G
-
-
W
L
AG
V
T
W
FR
N
D
YR
NKIE
A
G
Y
V
AV
G
QN
AV
GT
DLYQ
W
D
N
V
P
KA
V
VEG
L
E
G
S
LN---V
P
-
VSE
TVM
W
TN
N
I
T
Y
MLK
S
E
N
K
T
T
----
-
-
-----
GDRL
S
II
PEY
TLN
S
TLSW
QA
RE
D
L
S
M
Q
TTF
T
W
YG
KQQ
P
KKY
-
N
Y
KG
QPAVG
P
ETKEIS
P
-
Y
SIV
G
L
S
AT
W
D
VTKN
V
S
LTGG
VDNLFD
K
R
L
WRAGNA
Q
T
T
G
DLA
GANY
I
A
GA
G
AYT
Y
N
-
E
PG
--
RT
WY
M
SV
NTHF
fig|413997.3.peg.577
Escherichia coli B str. REL606
MNKKIHSL
A
LLVNL
G
IYGVA
--
-
Q
A
Q
EP
TD
TPVSH
DDT
I
VVTA
-
A
E
Q
N
L
-
Q
AP
GV
S
---
-------------
T
I
T
A
DEIR
K
N
P
V
A
R
DVS
E
II
R
T
MPGVN
L
---
--
TGNST
S
G
Q
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
K
P
VS
S
R
NSV
RQGW
RGE
RDT
RG
DTSWVPPEM
I
E
R
I
EVLRGP
A
AA
R
YG
N
G
A
A
GG
V
V
NIITK
KG
SGEWH
G
SW
D
A
Y
F
NA
PE
H
KEEGATK
R
TN
FSLTGP
L
-
GD
EFSF
RLYG
NLD
--
KT
Q
A
D
AWD
IN
Q
--
G
HQSAR
AGTYATTLP
AGR
EG
V
I
N
K
DINGV
VR
WDF
AP
LQ
S
LELEA
G
YSRQGN
L
-
Y
AGD
TQ
NTNS
D
---------------
SY
T
RS
--
KY
G
D
-
E
T
NRL
Y
RQ
NY
A
LTWN
GG
WD
N
G
V
T
T
S
NWVQY
EH
-----------
TR
N
SR
IP
E
-
----
G
LA
G
-----
G
TEGKFNEK
A
TQDFVDI
D
L
D
D
V
M
L
H
SEV
N
-
-
-
LPIDF
L
V
--
NQT
----
--
--
--
--
--
LT
L
G
T
EWNQQ
R
M
KDLSS
N
TQA
L
TGT
N
T
---
GGA
I
--
D
G
V
S
T
TD
------------------
R
S
P
Y
SK
AE
I
F
S
L
F
A
EN
N
ME
LTD
S
T
I
V
T
P
GLRFD
H
H
SIVGN
N
WS
PALNISQGL
GD
D
-
---F
T
LKM
G
I
A
RA
----------------
Y
KA
P
S
LY
Q
TN
P
N
--
-
YI
L
Y
S
----
-
K
G
Q
G
CY
A
--
S
AG
GCYLQGND
D
L
KAE
T
SIN
K
EIG
L
EFK
RD
G
-
-
W
L
AG
V
T
W
FR
N
D
YR
NKIE
A
G
Y
V
AV
G
QN
AV
GT
DLYQ
W
D
N
V
P
KA
V
VEG
L
E
G
S
LN---V
P
-
VSE
TVM
W
TN
N
I
T
Y
MLK
S
E
N
K
T
T
----
-
-
-----
GDRL
S
II
PEY
TLN
S
TLSW
QA
RE
D
L
S
M
Q
TTF
T
W
YG
KQQ
P
KKY
-
N
Y
KG
QPAVG
P
ETKEIS
P
-
Y
SIV
G
L
S
AT
W
D
VTKN
V
S
LTGG
VDNLFD
K
R
L
WRAGNA
Q
T
T
G
DLA
GANY
I
A
GA
G
AYT
Y
N
-
E
PG
--
RT
WY
M
SV
NTHF
fig|511693.5.peg.573
Escherichia coli BL21
MNKKIHSL
A
LLVNL
G
IYGVA
--
-
Q
A
Q
EP
TD
TPVSH
DDT
I
VVTA
-
A
E
Q
N
L
-
Q
AP
GV
S
---
-------------
T
I
T
A
DEIR
K
N
P
V
A
R
DVS
E
II
R
T
MPGVN
L
---
--
TGNST
S
G
Q
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
K
P
VS
S
R
NSV
RQGW
RGE
RDT
RG
DTSWVPPEM
I
E
R
I
EVLRGP
A
AA
R
YG
N
G
A
A
GG
V
V
NIITK
KG
SGEWH
G
SW
D
A
Y
F
NA
PE
H
KEEGATK
R
TN
FSLTGP
L
-
GD
EFSF
RLYG
NLD
--
KT
Q
A
D
AWD
IN
Q
--
G
HQSAR
AGTYATTLP
AGR
EG
V
I
N
K
DINGV
VR
WDF
AP
LQ
S
LELEA
G
YSRQGN
L
-
Y
AGD
TQ
NTNS
D
---------------
SY
T
RS
--
KY
G
D
-
E
T
NRL
Y
RQ
NY
A
LTWN
GG
WD
N
G
V
T
T
S
NWVQY
EH
-----------
TR
N
SR
IP
E
-
----
G
LA
G
-----
G
TEGKFNEK
A
TQDFVDI
D
L
D
D
V
M
L
H
SEV
N
-
-
-
LPIDF
L
V
--
NQT
----
--
--
--
--
--
LT
L
G
T
EWNQQ
R
M
KDLSS
N
TQA
L
TGT
N
T
---
GGA
I
--
D
G
V
S
T
TD
------------------
R
S
P
Y
SK
AE
I
F
S
L
F
A
EN
N
ME
LTD
S
T
I
V
T
P
GLRFD
H
H
SIVGN
N
WS
PALNISQGL
GD
D
-
---F
T
LKM
G
I
A
RA
----------------
Y
KA
P
S
LY
Q
TN
P
N
--
-
YI
L
Y
S
----
-
K
G
Q
G
CY
A
--
S
AG
GCYLQGND
D
L
KAE
T
SIN
K
EIG
L
EFK
RD
G
-
-
W
L
AG
V
T
W
FR
N
D
YR
NKIE
A
G
Y
V
AV
G
QN
AV
GT
DLYQ
W
D
N
V
P
KA
V
VEG
L
E
G
S
LN---V
P
-
VSE
TVM
W
TN
N
I
T
Y
MLK
S
E
N
K
T
T
----
-
-
-----
GDRL
S
II
PEY
TLN
S
TLSW
QA
RE
D
L
S
M
Q
TTF
T
W
YG
KQQ
P
KKY
-
N
Y
KG
QPAVG
P
ETKEIS
P
-
Y
SIV
G
L
S
AT
W
D
VTKN
V
S
LTGG
VDNLFD
K
R
L
WRAGNA
Q
T
T
G
DLA
GANY
I
A
GA
G
AYT
Y
N
-
E
PG
--
RT
WY
M
SV
NTHF
fig|469008.4.peg.3182
Escherichia coli BL21(DE3)
MNKKIHSL
A
LLVNL
G
IYGVA
--
-
Q
A
Q
EP
TD
TPVSH
DDT
I
VVTA
-
A
E
Q
N
L
-
Q
AP
GV
S
---
-------------
T
I
T
A
DEIR
K
N
P
V
A
R
DVS
E
II
R
T
MPGVN
L
---
--
TGNST
S
G
Q
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
K
P
VS
S
R
NSV
RQGW
RGE
RDT
RG
DTSWVPPEM
I
E
R
I
EVLRGP
A
AA
R
YG
N
G
A
A
GG
V
V
NIITK
KG
SGEWH
G
SW
D
A
Y
F
NA
PE
H
KEEGATK
R
TN
FSLTGP
L
-
GD
EFSF
RLYG
NLD
--
KT
Q
A
D
AWD
IN
Q
--
G
HQSAR
AGTYATTLP
AGR
EG
V
I
N
K
DINGV
VR
WDF
AP
LQ
S
LELEA
G
YSRQGN
L
-
Y
AGD
TQ
NTNS
D
---------------
SY
T
RS
--
KY
G
D
-
E
T
NRL
Y
RQ
NY
A
LTWN
GG
WD
N
G
V
T
T
S
NWVQY
EH
-----------
TR
N
SR
IP
E
-
----
G
LA
G
-----
G
TEGKFNEK
A
TQDFVDI
D
L
D
D
V
M
L
H
SEV
N
-
-
-
LPIDF
L
V
--
NQT
----
--
--
--
--
--
LT
L
G
T
EWNQQ
R
M
KDLSS
N
TQA
L
TGT
N
T
---
GGA
I
--
D
G
V
S
T
TD
------------------
R
S
P
Y
SK
AE
I
F
S
L
F
A
EN
N
ME
LTD
S
T
I
V
T
P
GLRFD
H
H
SIVGN
N
WS
PALNISQGL
GD
D
-
---F
T
LKM
G
I
A
RA
----------------
Y
KA
P
S
LY
Q
TN
P
N
--
-
YI
L
Y
S
----
-
K
G
Q
G
CY
A
--
S
AG
GCYLQGND
D
L
KAE
T
SIN
K
EIG
L
EFK
RD
G
-
-
W
L
AG
V
T
W
FR
N
D
YR
NKIE
A
G
Y
V
AV
G
QN
AV
GT
DLYQ
W
D
N
V
P
KA
V
VEG
L
E
G
S
LN---V
P
-
VSE
TVM
W
TN
N
I
T
Y
MLK
S
E
N
K
T
T
----
-
-
-----
GDRL
S
II
PEY
TLN
S
TLSW
QA
RE
D
L
S
M
Q
TTF
T
W
YG
KQQ
P
KKY
-
N
Y
KG
QPAVG
P
ETKEIS
P
-
Y
SIV
G
L
S
AT
W
D
VTKN
V
S
LTGG
VDNLFD
K
R
L
WRAGNA
Q
T
T
G
DLA
GANY
I
A
GA
G
AYT
Y
N
-
E
PG
--
RT
WY
M
SV
NTHF
fig|316401.4.peg.702
Escherichia coli ETEC H10407
MNKKIHSL
A
LLVNL
G
IYGVA
--
-
Q
A
Q
EP
TD
TPVSH
DDT
I
VVTA
-
A
E
Q
N
L
-
Q
AP
GV
S
---
-------------
T
I
T
A
DEIR
K
N
P
V
A
R
DVS
E
II
R
T
MPGVN
L
---
--
TGNST
S
G
Q
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
K
P
VS
S
R
NSV
RQGW
RGE
RDT
RG
DTSWVPPEM
I
E
R
I
EVLRGP
A
AA
R
YG
N
G
A
A
GG
V
V
NIITK
KG
SGEWH
G
SW
D
A
Y
F
NA
PE
H
KEEGATK
R
TN
FSLTGP
L
-
GD
EFSF
RLYG
NLD
--
KT
Q
A
D
AWD
IN
Q
--
G
HQSAR
AGTYATTLP
AGR
EG
V
I
N
K
DINGV
VR
WDF
AP
LQ
S
LELEA
G
YSRQGN
L
-
Y
AGD
TQ
NTNS
D
---------------
SY
T
RS
--
KY
G
D
-
E
T
NRL
Y
RQ
NY
A
LTWN
GG
WD
N
G
V
T
T
S
NWVQY
EH
-----------
TR
N
SR
IP
E
-
----
G
LA
G
-----
G
TEGKFNEK
A
TQDFVDI
D
L
D
D
V
M
L
H
SEV
N
-
-
-
LPIDF
L
V
--
NQT
----
--
--
--
--
--
LT
L
G
T
EWNQQ
R
M
KDLSS
N
TQA
L
TGT
N
T
---
GGA
I
--
D
G
V
S
T
TD
------------------
R
S
P
Y
SK
AE
I
F
S
L
F
A
EN
N
ME
LTD
S
T
I
V
T
P
GLRFD
H
H
SIVGN
N
WS
PALNISQGL
GD
D
-
---F
T
LKM
G
I
A
RA
----------------
Y
KA
P
S
LY
Q
TN
P
N
--
-
YI
L
Y
S
----
-
K
G
Q
G
CY
A
--
S
AG
GCYLQGND
D
L
KAE
T
SIN
K
EIG
L
EFK
RD
G
-
-
W
L
AG
V
T
W
FR
N
D
YR
NKIE
A
G
Y
V
AV
G
QN
AV
GT
DLYQ
W
D
N
V
P
KA
V
VEG
L
E
G
S
LN---V
P
-
VSE
TVM
W
TN
N
I
T
Y
MLK
S
E
N
K
T
T
----
-
-
-----
GDRL
S
II
PEY
TLN
S
TLSW
QA
RE
D
L
S
M
Q
TTF
T
W
YG
KQQ
P
KKY
-
N
Y
KG
QPAVG
P
ETKEIS
P
-
Y
SIV
G
L
S
AT
W
D
VTKN
V
S
LTGG
VDNLFD
K
R
L
WRAGNA
Q
T
T
G
DLA
GANY
I
A
GA
G
AYT
Y
N
-
E
PG
--
RT
WY
M
SV
NTHF
fig|656414.3.peg.758
Escherichia coli H736
MNKKIHSL
A
LLVNL
G
IYGVA
--
-
Q
A
Q
EP
TD
TPVSH
DDT
I
VVTA
-
A
E
Q
N
L
-
Q
AP
GV
S
---
-------------
T
I
T
A
DEIR
K
N
P
V
A
R
DVS
E
II
R
T
MPGVN
L
---
--
TGNST
S
G
Q
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
K
P
VS
S
R
NSV
RQGW
RGE
RDT
RG
DTSWVPPEM
I
E
R
I
EVLRGP
A
AA
R
YG
N
G
A
A
GG
V
V
NIITK
KG
SGEWH
G
SW
D
A
Y
F
NA
PE
H
KEEGATK
R
TN
FSLTGP
L
-
GD
EFSF
RLYG
NLD
--
KT
Q
A
D
AWD
IN
Q
--
G
HQSAR
AGTYATTLP
AGR
EG
V
I
N
K
DINGV
VR
WDF
AP
LQ
S
LELEA
G
YSRQGN
L
-
Y
AGD
TQ
NTNS
D
---------------
SY
T
RS
--
KY
G
D
-
E
T
NRL
Y
RQ
NY
A
LTWN
GG
WD
N
G
V
T
T
S
NWVQY
EH
-----------
TR
N
SR
IP
E
-
----
G
LA
G
-----
G
TEGKFNEK
A
TQDFVDI
D
L
D
D
V
M
L
H
SEV
N
-
-
-
LPIDF
L
V
--
NQT
----
--
--
--
--
--
LT
L
G
T
EWNQQ
R
M
KDLSS
N
TQA
L
TGT
N
T
---
GGA
I
--
D
G
V
S
T
TD
------------------
R
S
P
Y
SK
AE
I
F
S
L
F
A
EN
N
ME
LTD
S
T
I
V
T
P
GLRFD
H
H
SIVGN
N
WS
PALNISQGL
GD
D
-
---F
T
LKM
G
I
A
RA
----------------
Y
KA
P
S
LY
Q
TN
P
N
--
-
YI
L
Y
S
----
-
K
G
Q
G
CY
A
--
S
AG
GCYLQGND
D
L
KAE
T
SIN
K
EIG
L
EFK
RD
G
-
-
W
L
AG
V
T
W
FR
N
D
YR
NKIE
A
G
Y
V
AV
G
QN
AV
GT
DLYQ
W
D
N
V
P
KA
V
VEG
L
E
G
S
LN---V
P
-
VSE
TVM
W
TN
N
I
T
Y
MLK
S
E
N
K
T
T
----
-
-
-----
GDRL
S
II
PEY
TLN
S
TLSW
QA
RE
D
L
S
M
Q
TTF
T
W
YG
KQQ
P
KKY
-
N
Y
KG
QPAVG
P
ETKEIS
P
-
Y
SIV
G
L
S
AT
W
D
VTKN
V
S
LTGG
VDNLFD
K
R
L
WRAGNA
Q
T
T
G
DLA
GANY
I
A
GA
G
AYT
Y
N
-
E
PG
--
RT
WY
M
SV
NTHF
fig|749540.3.peg.4747
Escherichia coli MS 146-1
MNKKIHSL
A
LLVNL
G
IYGVA
--
-
Q
A
Q
EP
TD
TPVSH
DDT
I
VVTA
-
A
E
Q
N
L
-
Q
AP
GV
S
---
-------------
T
I
T
A
DEIR
K
N
P
V
A
R
DVS
E
II
R
T
MPGVN
L
---
--
TGNST
S
G
Q
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
K
P
VS
S
R
NSV
RQGW
RGE
RDT
RG
DTSWVPPEM
I
E
R
I
EVLRGP
A
AA
R
YG
N
G
A
A
GG
V
V
NIITK
KG
SGEWH
G
SW
D
A
Y
F
NA
PE
H
KEEGATK
R
TN
FSLTGP
L
-
GD
EFSF
RLYG
NLD
--
KT
Q
A
D
AWD
IN
Q
--
G
HQSAR
AGTYATTLP
AGR
EG
V
I
N
K
DINGV
VR
WDF
AP
LQ
S
LELEA
G
YSRQGN
L
-
Y
AGD
TQ
NTNS
D
---------------
SY
T
RS
--
KY
G
D
-
E
T
NRL
Y
RQ
NY
A
LTWN
GG
WD
N
G
V
T
T
S
NWVQY
EH
-----------
TR
N
SR
IP
E
-
----
G
LA
G
-----
G
TEGKFNEK
A
TQDFVDI
D
L
D
D
V
M
L
H
SEV
N
-
-
-
LPIDF
L
V
--
NQT
----
--
--
--
--
--
LT
L
G
T
EWNQQ
R
M
KDLSS
N
TQA
L
TGT
N
T
---
GGA
I
--
D
G
V
S
T
TD
------------------
R
S
P
Y
SK
AE
I
F
S
L
F
A
EN
N
ME
LTD
S
T
I
V
T
P
GLRFD
H
H
SIVGN
N
WS
PALNISQGL
GD
D
-
---F
T
LKM
G
I
A
RA
----------------
Y
KA
P
S
LY
Q
TN
P
N
--
-
YI
L
Y
S
----
-
K
G
Q
G
CY
A
--
S
AG
GCYLQGND
D
L
KAE
T
SIN
K
EIG
L
EFK
RD
G
-
-
W
L
AG
V
T
W
FR
N
D
YR
NKIE
A
G
Y
V
AV
G
QN
AV
GT
DLYQ
W
D
N
V
P
KA
V
VEG
L
E
G
S
LN---V
P
-
VSE
TVM
W
TN
N
I
T
Y
MLK
S
E
N
K
T
T
----
-
-
-----
GDRL
S
II
PEY
TLN
S
TLSW
QA
RE
D
L
S
M
Q
TTF
T
W
YG
KQQ
P
KKY
-
N
Y
KG
QPAVG
P
ETKEIS
P
-
Y
SIV
G
L
S
AT
W
D
VTKN
V
S
LTGG
VDNLFD
K
R
L
WRAGNA
Q
T
T
G
DLA
GANY
I
A
GA
G
AYT
Y
N
-
E
PG
--
RT
WY
M
SV
NTHF
fig|749548.3.peg.4449
Escherichia coli MS 196-1
MNKKIHSL
A
LLVNL
G
IYGVA
--
-
Q
A
Q
EP
TD
TPVSH
DDT
I
VVTA
-
A
E
Q
N
L
-
Q
AP
GV
S
---
-------------
T
I
T
A
DEIR
K
N
P
V
A
R
DVS
E
II
R
T
MPGVN
L
---
--
TGNST
S
G
Q
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
K
P
VS
S
R
NSV
RQGW
RGE
RDT
RG
DTSWVPPEM
I
E
R
I
EVLRGP
A
AA
R
YG
N
G
A
A
GG
V
V
NIITK
KG
SGEWH
G
SW
D
A
Y
F
NA
PE
H
KEEGATK
R
TN
FSLTGP
L
-
GD
EFSF
RLYG
NLD
--
KT
Q
A
D
AWD
IN
Q
--
G
HQSAR
AGTYATTLP
AGR
EG
V
I
N
K
DINGV
VR
WDF
AP
LQ
S
LELEA
G
YSRQGN
L
-
Y
AGD
TQ
NTNS
D
---------------
SY
T
RS
--
KY
G
D
-
E
T
NRL
Y
RQ
NY
A
LTWN
GG
WD
N
G
V
T
T
S
NWVQY
EH
-----------
TR
N
SR
IP
E
-
----
G
LA
G
-----
G
TEGKFNEK
A
TQDFVDI
D
L
D
D
V
M
L
H
SEV
N
-
-
-
LPIDF
L
V
--
NQT
----
--
--
--
--
--
LT
L
G
T
EWNQQ
R
M
KDLSS
N
TQA
L
TGT
N
T
---
GGA
I
--
D
G
V
S
T
TD
------------------
R
S
P
Y
SK
AE
I
F
S
L
F
A
EN
N
ME
LTD
S
T
I
V
T
P
GLRFD
H
H
SIVGN
N
WS
PALNISQGL
GD
D
-
---F
T
LKM
G
I
A
RA
----------------
Y
KA
P
S
LY
Q
TN
P
N
--
-
YI
L
Y
S
----
-
K
G
Q
G
CY
A
--
S
AG
GCYLQGND
D
L
KAE
T
SIN
K
EIG
L
EFK
RD
G
-
-
W
L
AG
V
T
W
FR
N
D
YR
NKIE
A
G
Y
V
AV
G
QN
AV
GT
DLYQ
W
D
N
V
P
KA
V
VEG
L
E
G
S
LN---V
P
-
VSE
TVM
W
TN
N
I
T
Y
MLK
S
E
N
K
T
T
----
-
-
-----
GDRL
S
II
PEY
TLN
S
TLSW
QA
RE
D
L
S
M
Q
TTF
T
W
YG
KQQ
P
KKY
-
N
Y
KG
QPAVG
P
ETKEIS
P
-
Y
SIV
G
L
S
AT
W
D
VTKN
V
S
LTGG
VDNLFD
K
R
L
WRAGNA
Q
T
T
G
DLA
GANY
I
A
GA
G
AYT
Y
N
-
E
PG
--
RT
WY
M
SV
NTHF
fig|525281.3.peg.2355
Escherichia coli 83972
MNKKIHSL
A
LLVNL
G
IYGVA
--
-
Q
A
Q
EP
TD
TPVSH
DDT
I
VVTA
-
A
E
Q
N
L
-
Q
AP
GV
S
---
-------------
T
I
T
A
DEIR
K
N
P
V
A
R
DVS
E
II
R
T
MPGVN
L
---
--
TGNST
S
G
Q
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
K
P
VS
S
R
NSV
RQGW
RGE
RDT
RG
DTSWVPPEM
I
E
R
I
EVLRGP
A
AA
R
YG
N
G
A
A
GG
V
V
NIITK
KG
SGEWH
G
SW
D
A
Y
F
NA
PE
H
KEEGATK
R
TN
FSLTGP
L
-
GD
EFSF
RLYG
NLD
--
KT
Q
A
D
AWD
IN
Q
--
G
HQSAR
AGT
H
ATTLP
AGR
EG
V
I
N
K
DINGV
VR
WDF
AP
LQ
S
LELEA
G
YSRQGN
L
-
Y
AGD
TQ
NTNS
D
---------------
AY
T
RS
--
KY
G
D
-
E
T
NRL
Y
RQ
NY
S
LTWN
GG
WD
N
G
V
T
T
S
NWVQY
EH
-----------
TR
N
SR
IP
E
-
----
G
LA
G
-----
G
TEGKFNEK
A
AQDFVDI
D
L
D
D
V
M
L
H
SEV
N
-
-
-
LPIDF
L
V
--
NQT
----
--
--
--
--
--
LT
L
G
T
EWNQQ
R
M
KDLSS
N
TQA
L
TGT
N
T
---
GGA
I
--
D
G
V
S
A
TD
------------------
R
S
P
Y
SK
AE
I
F
S
L
F
A
EN
N
ME
LTD
S
T
I
V
T
P
GLRFD
H
H
SIVGN
N
WS
PALNISQGL
GD
D
-
---F
T
LKM
G
I
A
RA
----------------
Y
KA
P
S
LY
Q
TN
P
N
--
-
YI
L
Y
S
----
-
K
G
Q
G
CY
A
--
S
AG
GCYLQGND
D
L
KAE
T
SIN
K
EIG
L
EFK
RD
G
-
-
W
L
AG
V
T
W
FR
N
D
YR
NKIE
A
G
Y
V
AV
G
QN
AV
GT
DLYQ
W
D
N
V
P
KA
V
VEG
L
E
G
S
LN---V
P
-
VSE
TVM
W
TN
N
I
T
Y
MLK
S
E
N
K
T
T
----
-
-
-----
GDRL
S
II
PEY
TLN
S
TLSW
QA
RE
D
L
S
M
Q
TTF
T
W
YG
KQQ
P
KKY
-
N
Y
KG
QPAVG
P
ETKEIS
P
-
Y
SIV
G
L
S
AT
W
D
VTKN
V
S
LTGG
VDNLFD
K
R
L
WRAGNA
Q
T
T
G
DLA
GANY
I
A
GA
G
AYT
Y
N
-
E
PG
--
RT
WY
M
SI
NTHF
fig|655817.3.peg.676
Escherichia coli ABU 83972
MNKKIHSL
A
LLVNL
G
IYGVA
--
-
Q
A
Q
EP
TD
TPVSH
DDT
I
VVTA
-
A
E
Q
N
L
-
Q
AP
GV
S
---
-------------
T
I
T
A
DEIR
K
N
P
V
A
R
DVS
E
II
R
T
MPGVN
L
---
--
TGNST
S
G
Q
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
K
P
VS
S
R
NSV
RQGW
RGE
RDT
RG
DTSWVPPEM
I
E
R
I
EVLRGP
A
AA
R
YG
N
G
A
A
GG
V
V
NIITK
KG
SGEWH
G
SW
D
A
Y
F
NA
PE
H
KEEGATK
R
TN
FSLTGP
L
-
GD
EFSF
RLYG
NLD
--
KT
Q
A
D
AWD
IN
Q
--
G
HQSAR
AGT
H
ATTLP
AGR
EG
V
I
N
K
DINGV
VR
WDF
AP
LQ
S
LELEA
G
YSRQGN
L
-
Y
AGD
TQ
NTNS
D
---------------
AY
T
RS
--
KY
G
D
-
E
T
NRL
Y
RQ
NY
S
LTWN
GG
WD
N
G
V
T
T
S
NWVQY
EH
-----------
TR
N
SR
IP
E
-
----
G
LA
G
-----
G
TEGKFNEK
A
AQDFVDI
D
L
D
D
V
M
L
H
SEV
N
-
-
-
LPIDF
L
V
--
NQT
----
--
--
--
--
--
LT
L
G
T
EWNQQ
R
M
KDLSS
N
TQA
L
TGT
N
T
---
GGA
I
--
D
G
V
S
A
TD
------------------
R
S
P
Y
SK
AE
I
F
S
L
F
A
EN
N
ME
LTD
S
T
I
V
T
P
GLRFD
H
H
SIVGN
N
WS
PALNISQGL
GD
D
-
---F
T
LKM
G
I
A
RA
----------------
Y
KA
P
S
LY
Q
TN
P
N
--
-
YI
L
Y
S
----
-
K
G
Q
G
CY
A
--
S
AG
GCYLQGND
D
L
KAE
T
SIN
K
EIG
L
EFK
RD
G
-
-
W
L
AG
V
T
W
FR
N
D
YR
NKIE
A
G
Y
V
AV
G
QN
AV
GT
DLYQ
W
D
N
V
P
KA
V
VEG
L
E
G
S
LN---V
P
-
VSE
TVM
W
TN
N
I
T
Y
MLK
S
E
N
K
T
T
----
-
-
-----
GDRL
S
II
PEY
TLN
S
TLSW
QA
RE
D
L
S
M
Q
TTF
T
W
YG
KQQ
P
KKY
-
N
Y
KG
QPAVG
P
ETKEIS
P
-
Y
SIV
G
L
S
AT
W
D
VTKN
V
S
LTGG
VDNLFD
K
R
L
WRAGNA
Q
T
T
G
DLA
GANY
I
A
GA
G
AYT
Y
N
-
E
PG
--
RT
WY
M
SI
NTHF
fig|585057.4.peg.598
Escherichia coli IAI39
MNKKIHSL
A
LLVNL
G
IYGVA
--
-
Q
A
Q
EP
TD
TPVSH
DDT
I
VVTA
-
A
E
Q
N
L
-
Q
AP
GV
S
---
-------------
T
I
T
A
DEIR
K
N
P
V
A
R
DVS
E
II
R
T
MPGVN
L
---
--
TGNST
S
G
Q
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
K
P
VS
S
R
NSV
RQGW
RGE
RDT
RG
DTSWVPPEM
I
E
R
I
EVLRGP
A
AA
R
YG
N
G
A
A
GG
V
V
NIITK
KG
SGEWH
G
SW
D
A
Y
F
NA
PE
H
KEEGATK
R
TN
FSLTGP
L
-
GD
EFSF
RLYG
NLD
--
KT
Q
A
D
AWD
IN
Q
--
G
HQSAR
AGTYATTLP
AGR
EG
V
I
N
K
DINGV
VR
WDF
AP
LQ
S
LELEA
G
YSRQGN
L
-
Y
AGD
TQ
NTNS
D
---------------
SY
T
RS
--
KY
G
D
-
E
T
NRL
Y
RQ
NY
S
LTWN
GG
WD
N
G
V
T
T
S
NWVQY
EH
-----------
TR
N
SR
IP
E
-
----
G
LA
G
-----
G
TEGKFNEK
A
TQDFVDI
D
L
D
D
V
M
L
H
SEV
N
-
-
-
LPIDF
L
V
--
NQT
----
--
--
--
--
--
LT
L
G
T
EWNQQ
R
M
KDLSS
N
TQA
L
TGT
N
T
---
GGA
I
--
D
G
V
S
A
TD
------------------
R
S
P
Y
SK
AE
I
F
S
L
F
A
EN
N
ME
V
TD
S
T
I
V
T
P
GLRFD
H
H
SIVGN
N
WS
PALNISQGL
GD
D
-
---F
T
LKM
G
I
A
RA
----------------
Y
KA
P
S
LY
Q
TN
P
N
--
-
YI
L
Y
S
----
-
K
G
Q
G
CY
A
--
S
AG
GCYLQGND
D
L
KAE
T
SIN
K
EIG
L
EFK
RD
G
-
-
W
L
AG
V
T
W
FR
N
D
YR
NKIE
A
G
Y
V
AV
G
QN
AV
GT
DLYQ
W
D
N
V
P
KA
V
VEG
L
E
G
S
LN---V
P
-
VSE
TVM
W
TN
N
I
T
Y
MLK
S
E
N
K
T
T
----
-
-
-----
GDRL
S
II
PEY
TLN
S
TLSW
QA
RE
D
L
S
M
Q
TTF
T
W
YG
KQQ
P
KKY
-
N
Y
KG
QPAVG
P
ETKEIS
P
-
Y
SIV
G
L
S
AT
W
D
VTKN
V
S
LTGG
VDNLFD
K
R
L
WRAGNA
Q
T
T
G
DLA
GANY
I
A
GA
G
AYT
Y
N
-
E
PG
--
RT
WY
M
SV
NTHF
fig|585057.6.peg.596
Escherichia coli IAI39
MNKKIHSL
A
LLVNL
G
IYGVA
--
-
Q
A
Q
EP
TD
TPVSH
DDT
I
VVTA
-
A
E
Q
N
L
-
Q
AP
GV
S
---
-------------
T
I
T
A
DEIR
K
N
P
V
A
R
DVS
E
II
R
T
MPGVN
L
---
--
TGNST
S
G
Q
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
K
P
VS
S
R
NSV
RQGW
RGE
RDT
RG
DTSWVPPEM
I
E
R
I
EVLRGP
A
AA
R
YG
N
G
A
A
GG
V
V
NIITK
KG
SGEWH
G
SW
D
A
Y
F
NA
PE
H
KEEGATK
R
TN
FSLTGP
L
-
GD
EFSF
RLYG
NLD
--
KT
Q
A
D
AWD
IN
Q
--
G
HQSAR
AGTYATTLP
AGR
EG
V
I
N
K
DINGV
VR
WDF
AP
LQ
S
LELEA
G
YSRQGN
L
-
Y
AGD
TQ
NTNS
D
---------------
SY
T
RS
--
KY
G
D
-
E
T
NRL
Y
RQ
NY
S
LTWN
GG
WD
N
G
V
T
T
S
NWVQY
EH
-----------
TR
N
SR
IP
E
-
----
G
LA
G
-----
G
TEGKFNEK
A
TQDFVDI
D
L
D
D
V
M
L
H
SEV
N
-
-
-
LPIDF
L
V
--
NQT
----
--
--
--
--
--
LT
L
G
T
EWNQQ
R
M
KDLSS
N
TQA
L
TGT
N
T
---
GGA
I
--
D
G
V
S
A
TD
------------------
R
S
P
Y
SK
AE
I
F
S
L
F
A
EN
N
ME
V
TD
S
T
I
V
T
P
GLRFD
H
H
SIVGN
N
WS
PALNISQGL
GD
D
-
---F
T
LKM
G
I
A
RA
----------------
Y
KA
P
S
LY
Q
TN
P
N
--
-
YI
L
Y
S
----
-
K
G
Q
G
CY
A
--
S
AG
GCYLQGND
D
L
KAE
T
SIN
K
EIG
L
EFK
RD
G
-
-
W
L
AG
V
T
W
FR
N
D
YR
NKIE
A
G
Y
V
AV
G
QN
AV
GT
DLYQ
W
D
N
V
P
KA
V
VEG
L
E
G
S
LN---V
P
-
VSE
TVM
W
TN
N
I
T
Y
MLK
S
E
N
K
T
T
----
-
-
-----
GDRL
S
II
PEY
TLN
S
TLSW
QA
RE
D
L
S
M
Q
TTF
T
W
YG
KQQ
P
KKY
-
N
Y
KG
QPAVG
P
ETKEIS
P
-
Y
SIV
G
L
S
AT
W
D
VTKN
V
S
LTGG
VDNLFD
K
R
L
WRAGNA
Q
T
T
G
DLA
GANY
I
A
GA
G
AYT
Y
N
-
E
PG
--
RT
WY
M
SV
NTHF
fig|595496.3.peg.506
Escherichia coli BW2952
MNKKIHSL
A
LLVNL
G
IYGVA
--
-
Q
A
Q
EP
TD
TPVSH
DDT
I
VVTA
-
A
E
Q
N
L
-
Q
AP
GV
S
---
-------------
T
I
T
A
DEIR
K
N
P
V
A
R
DVS
K
II
R
T
MPGVN
L
---
--
TGNST
S
G
Q
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
K
P
VS
S
R
NSV
RQGW
RGE
RDT
RG
DTSWVPPEM
I
E
R
I
EVLRGP
A
AA
R
YG
N
G
A
A
GG
V
V
NIITK
KG
SGEWH
G
SW
D
A
Y
F
NA
PE
H
KEEGATK
R
TN
FSLTGP
L
-
GD
EFSF
RLYG
NLD
--
KT
Q
A
D
AWD
IN
Q
--
G
HQSAR
AGTYATTLP
AGR
EG
V
I
N
K
DINGV
VR
WDF
AP
LQ
S
LELEA
G
YSRQGN
L
-
Y
AGD
TQ
NTNS
D
---------------
SY
T
RS
--
KY
G
D
-
E
T
NRL
Y
RQ
NY
A
LTWN
GG
WD
N
G
V
T
T
S
NWVQY
EH
-----------
TR
N
SR
IP
E
-
----
G
LA
G
-----
G
TEGKFNEK
A
TQDFVDI
D
L
D
D
V
M
L
H
SEV
N
-
-
-
LPIDF
L
V
--
NQT
----
--
--
--
--
--
LT
L
G
T
EWNQQ
R
M
KDLSS
N
TQA
L
TGT
N
T
---
GGA
I
--
D
G
V
S
T
TD
------------------
R
S
P
Y
SK
AE
I
F
S
L
F
A
EN
N
ME
LTD
S
T
I
V
T
P
GLRFD
H
H
SIVGN
N
WS
PALNISQGL
GD
D
-
---F
T
LKM
G
I
A
RA
----------------
Y
KA
P
S
LY
Q
TN
P
N
--
-
YI
L
Y
S
----
-
K
G
Q
G
CY
A
--
S
AG
GCYLQGND
D
L
KAE
T
SIN
K
EIG
L
EFK
RD
G
-
-
W
L
AG
V
T
W
FR
N
D
YR
NKIE
A
G
Y
V
AV
G
QN
AV
GT
DLYQ
W
D
N
V
P
KA
V
VEG
L
E
G
S
LN---V
P
-
VSE
TVM
W
TN
N
I
T
Y
MLK
S
E
N
K
T
T
----
-
-
-----
GDRL
S
II
PEY
TLN
S
TLSW
QA
RE
D
L
S
M
Q
TTF
T
W
YG
KQQ
P
KKY
-
N
Y
KG
QPAVG
P
ETKEIS
P
-
Y
SIV
G
L
S
AT
W
D
VTKN
V
S
LTGG
VDNLFD
K
R
L
WRAGNA
Q
T
T
G
DLA
GANY
I
A
GA
G
AYT
Y
N
-
E
PG
--
RT
WY
M
SV
NTHF
fig|536056.3.peg.3217
Escherichia coli DH1
MNKKIHSL
A
LLVNL
G
IYGVA
--
-
Q
A
Q
EP
TD
TPVSH
DDT
I
VVTA
-
A
E
Q
N
L
-
Q
AP
GV
S
---
-------------
T
I
T
A
DEIR
K
N
P
V
A
R
DVS
K
II
R
T
MPGVN
L
---
--
TGNST
S
G
Q
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
K
P
VS
S
R
NSV
RQGW
RGE
RDT
RG
DTSWVPPEM
I
E
R
I
EVLRGP
A
AA
R
YG
N
G
A
A
GG
V
V
NIITK
KG
SGEWH
G
SW
D
A
Y
F
NA
PE
H
KEEGATK
R
TN
FSLTGP
L
-
GD
EFSF
RLYG
NLD
--
KT
Q
A
D
AWD
IN
Q
--
G
HQSAR
AGTYATTLP
AGR
EG
V
I
N
K
DINGV
VR
WDF
AP
LQ
S
LELEA
G
YSRQGN
L
-
Y
AGD
TQ
NTNS
D
---------------
SY
T
RS
--
KY
G
D
-
E
T
NRL
Y
RQ
NY
A
LTWN
GG
WD
N
G
V
T
T
S
NWVQY
EH
-----------
TR
N
SR
IP
E
-
----
G
LA
G
-----
G
TEGKFNEK
A
TQDFVDI
D
L
D
D
V
M
L
H
SEV
N
-
-
-
LPIDF
L
V
--
NQT
----
--
--
--
--
--
LT
L
G
T
EWNQQ
R
M
KDLSS
N
TQA
L
TGT
N
T
---
GGA
I
--
D
G
V
S
T
TD
------------------
R
S
P
Y
SK
AE
I
F
S
L
F
A
EN
N
ME
LTD
S
T
I
V
T
P
GLRFD
H
H
SIVGN
N
WS
PALNISQGL
GD
D
-
---F
T
LKM
G
I
A
RA
----------------
Y
KA
P
S
LY
Q
TN
P
N
--
-
YI
L
Y
S
----
-
K
G
Q
G
CY
A
--
S
AG
GCYLQGND
D
L
KAE
T
SIN
K
EIG
L
EFK
RD
G
-
-
W
L
AG
V
T
W
FR
N
D
YR
NKIE
A
G
Y
V
AV
G
QN
AV
GT
DLYQ
W
D
N
V
P
KA
V
VEG
L
E
G
S
LN---V
P
-
VSE
TVM
W
TN
N
I
T
Y
MLK
S
E
N
K
T
T
----
-
-
-----
GDRL
S
II
PEY
TLN
S
TLSW
QA
RE
D
L
S
M
Q
TTF
T
W
YG
KQQ
P
KKY
-
N
Y
KG
QPAVG
P
ETKEIS
P
-
Y
SIV
G
L
S
AT
W
D
VTKN
V
S
LTGG
VDNLFD
K
R
L
WRAGNA
Q
T
T
G
DLA
GANY
I
A
GA
G
AYT
Y
N
-
E
PG
--
RT
WY
M
SV
NTHF
fig|83333.1.peg.583
Escherichia coli K12
MNKKIHSL
A
LLVNL
G
IYGVA
--
-
Q
A
Q
EP
TD
TPVSH
DDT
I
VVTA
-
A
E
Q
N
L
-
Q
AP
GV
S
---
-------------
T
I
T
A
DEIR
K
N
P
V
A
R
DVS
K
II
R
T
MPGVN
L
---
--
TGNST
S
G
Q
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
K
P
VS
S
R
NSV
RQGW
RGE
RDT
RG
DTSWVPPEM
I
E
R
I
EVLRGP
A
AA
R
YG
N
G
A
A
GG
V
V
NIITK
KG
SGEWH
G
SW
D
A
Y
F
NA
PE
H
KEEGATK
R
TN
FSLTGP
L
-
GD
EFSF
RLYG
NLD
--
KT
Q
A
D
AWD
IN
Q
--
G
HQSAR
AGTYATTLP
AGR
EG
V
I
N
K
DINGV
VR
WDF
AP
LQ
S
LELEA
G
YSRQGN
L
-
Y
AGD
TQ
NTNS
D
---------------
SY
T
RS
--
KY
G
D
-
E
T
NRL
Y
RQ
NY
A
LTWN
GG
WD
N
G
V
T
T
S
NWVQY
EH
-----------
TR
N
SR
IP
E
-
----
G
LA
G
-----
G
TEGKFNEK
A
TQDFVDI
D
L
D
D
V
M
L
H
SEV
N
-
-
-
LPIDF
L
V
--
NQT
----
--
--
--
--
--
LT
L
G
T
EWNQQ
R
M
KDLSS
N
TQA
L
TGT
N
T
---
GGA
I
--
D
G
V
S
T
TD
------------------
R
S
P
Y
SK
AE
I
F
S
L
F
A
EN
N
ME
LTD
S
T
I
V
T
P
GLRFD
H
H
SIVGN
N
WS
PALNISQGL
GD
D
-
---F
T
LKM
G
I
A
RA
----------------
Y
KA
P
S
LY
Q
TN
P
N
--
-
YI
L
Y
S
----
-
K
G
Q
G
CY
A
--
S
AG
GCYLQGND
D
L
KAE
T
SIN
K
EIG
L
EFK
RD
G
-
-
W
L
AG
V
T
W
FR
N
D
YR
NKIE
A
G
Y
V
AV
G
QN
AV
GT
DLYQ
W
D
N
V
P
KA
V
VEG
L
E
G
S
LN---V
P
-
VSE
TVM
W
TN
N
I
T
Y
MLK
S
E
N
K
T
T
----
-
-
-----
GDRL
S
II
PEY
TLN
S
TLSW
QA
RE
D
L
S
M
Q
TTF
T
W
YG
KQQ
P
KKY
-
N
Y
KG
QPAVG
P
ETKEIS
P
-
Y
SIV
G
L
S
AT
W
D
VTKN
V
S
LTGG
VDNLFD
K
R
L
WRAGNA
Q
T
T
G
DLA
GANY
I
A
GA
G
AYT
Y
N
-
E
PG
--
RT
WY
M
SV
NTHF
fig|316407.3.peg.566
Escherichia coli W3110
MNKKIHSL
A
LLVNL
G
IYGVA
--
-
Q
A
Q
EP
TD
TPVSH
DDT
I
VVTA
-
A
E
Q
N
L
-
Q
AP
GV
S
---
-------------
T
I
T
A
DEIR
K
N
P
V
A
R
DVS
K
II
R
T
MPGVN
L
---
--
TGNST
S
G
Q
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
K
P
VS
S
R
NSV
RQGW
RGE
RDT
RG
DTSWVPPEM
I
E
R
I
EVLRGP
A
AA
R
YG
N
G
A
A
GG
V
V
NIITK
KG
SGEWH
G
SW
D
A
Y
F
NA
PE
H
KEEGATK
R
TN
FSLTGP
L
-
GD
EFSF
RLYG
NLD
--
KT
Q
A
D
AWD
IN
Q
--
G
HQSAR
AGTYATTLP
AGR
EG
V
I
N
K
DINGV
VR
WDF
AP
LQ
S
LELEA
G
YSRQGN
L
-
Y
AGD
TQ
NTNS
D
---------------
SY
T
RS
--
KY
G
D
-
E
T
NRL
Y
RQ
NY
A
LTWN
GG
WD
N
G
V
T
T
S
NWVQY
EH
-----------
TR
N
SR
IP
E
-
----
G
LA
G
-----
G
TEGKFNEK
A
TQDFVDI
D
L
D
D
V
M
L
H
SEV
N
-
-
-
LPIDF
L
V
--
NQT
----
--
--
--
--
--
LT
L
G
T
EWNQQ
R
M
KDLSS
N
TQA
L
TGT
N
T
---
GGA
I
--
D
G
V
S
T
TD
------------------
R
S
P
Y
SK
AE
I
F
S
L
F
A
EN
N
ME
LTD
S
T
I
V
T
P
GLRFD
H
H
SIVGN
N
WS
PALNISQGL
GD
D
-
---F
T
LKM
G
I
A
RA
----------------
Y
KA
P
S
LY
Q
TN
P
N
--
-
YI
L
Y
S
----
-
K
G
Q
G
CY
A
--
S
AG
GCYLQGND
D
L
KAE
T
SIN
K
EIG
L
EFK
RD
G
-
-
W
L
AG
V
T
W
FR
N
D
YR
NKIE
A
G
Y
V
AV
G
QN
AV
GT
DLYQ
W
D
N
V
P
KA
V
VEG
L
E
G
S
LN---V
P
-
VSE
TVM
W
TN
N
I
T
Y
MLK
S
E
N
K
T
T
----
-
-
-----
GDRL
S
II
PEY
TLN
S
TLSW
QA
RE
D
L
S
M
Q
TTF
T
W
YG
KQQ
P
KKY
-
N
Y
KG
QPAVG
P
ETKEIS
P
-
Y
SIV
G
L
S
AT
W
D
VTKN
V
S
LTGG
VDNLFD
K
R
L
WRAGNA
Q
T
T
G
DLA
GANY
I
A
GA
G
AYT
Y
N
-
E
PG
--
RT
WY
M
SV
NTHF
fig|316385.5.peg.537
Escherichia coli str. K-12 substr. DH10B
MNKKIHSL
A
LLVNL
G
IYGVA
--
-
Q
A
Q
EP
TD
TPVSH
DDT
I
VVTA
-
A
E
Q
N
L
-
Q
AP
GV
S
---
-------------
T
I
T
A
DEIR
K
N
P
V
A
R
DVS
K
II
R
T
MPGVN
L
---
--
TGNST
S
G
Q
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
K
P
VS
S
R
NSV
RQGW
RGE
RDT
RG
DTSWVPPEM
I
E
R
I
EVLRGP
A
AA
R
YG
N
G
A
A
GG
V
V
NIITK
KG
SGEWH
G
SW
D
A
Y
F
NA
PE
H
KEEGATK
R
TN
FSLTGP
L
-
GD
EFSF
RLYG
NLD
--
KT
Q
A
D
AWD
IN
Q
--
G
HQSAR
AGTYATTLP
AGR
EG
V
I
N
K
DINGV
VR
WDF
AP
LQ
S
LELEA
G
YSRQGN
L
-
Y
AGD
TQ
NTNS
D
---------------
SY
T
RS
--
KY
G
D
-
E
T
NRL
Y
RQ
NY
A
LTWN
GG
WD
N
G
V
T
T
S
NWVQY
EH
-----------
TR
N
SR
IP
E
-
----
G
LA
G
-----
G
TEGKFNEK
A
TQDFVDI
D
L
D
D
V
M
L
H
SEV
N
-
-
-
LPIDF
L
V
--
NQT
----
--
--
--
--
--
LT
L
G
T
EWNQQ
R
M
KDLSS
N
TQA
L
TGT
N
T
---
GGA
I
--
D
G
V
S
T
TD
------------------
R
S
P
Y
SK
AE
I
F
S
L
F
A
EN
N
ME
LTD
S
T
I
V
T
P
GLRFD
H
H
SIVGN
N
WS
PALNISQGL
GD
D
-
---F
T
LKM
G
I
A
RA
----------------
Y
KA
P
S
LY
Q
TN
P
N
--
-
YI
L
Y
S
----
-
K
G
Q
G
CY
A
--
S
AG
GCYLQGND
D
L
KAE
T
SIN
K
EIG
L
EFK
RD
G
-
-
W
L
AG
V
T
W
FR
N
D
YR
NKIE
A
G
Y
V
AV
G
QN
AV
GT
DLYQ
W
D
N
V
P
KA
V
VEG
L
E
G
S
LN---V
P
-
VSE
TVM
W
TN
N
I
T
Y
MLK
S
E
N
K
T
T
----
-
-
-----
GDRL
S
II
PEY
TLN
S
TLSW
QA
RE
D
L
S
M
Q
TTF
T
W
YG
KQQ
P
KKY
-
N
Y
KG
QPAVG
P
ETKEIS
P
-
Y
SIV
G
L
S
AT
W
D
VTKN
V
S
LTGG
VDNLFD
K
R
L
WRAGNA
Q
T
T
G
DLA
GANY
I
A
GA
G
AYT
Y
N
-
E
PG
--
RT
WY
M
SV
NTHF
fig|316385.5.peg.648
Escherichia coli str. K-12 substr. DH10B
MNKKIHSL
A
LLVNL
G
IYGVA
--
-
Q
A
Q
EP
TD
TPVSH
DDT
I
VVTA
-
A
E
Q
N
L
-
Q
AP
GV
S
---
-------------
T
I
T
A
DEIR
K
N
P
V
A
R
DVS
K
II
R
T
MPGVN
L
---
--
TGNST
S
G
Q
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
K
P
VS
S
R
NSV
RQGW
RGE
RDT
RG
DTSWVPPEM
I
E
R
I
EVLRGP
A
AA
R
YG
N
G
A
A
GG
V
V
NIITK
KG
SGEWH
G
SW
D
A
Y
F
NA
PE
H
KEEGATK
R
TN
FSLTGP
L
-
GD
EFSF
RLYG
NLD
--
KT
Q
A
D
AWD
IN
Q
--
G
HQSAR
AGTYATTLP
AGR
EG
V
I
N
K
DINGV
VR
WDF
AP
LQ
S
LELEA
G
YSRQGN
L
-
Y
AGD
TQ
NTNS
D
---------------
SY
T
RS
--
KY
G
D
-
E
T
NRL
Y
RQ
NY
A
LTWN
GG
WD
N
G
V
T
T
S
NWVQY
EH
-----------
TR
N
SR
IP
E
-
----
G
LA
G
-----
G
TEGKFNEK
A
TQDFVDI
D
L
D
D
V
M
L
H
SEV
N
-
-
-
LPIDF
L
V
--
NQT
----
--
--
--
--
--
LT
L
G
T
EWNQQ
R
M
KDLSS
N
TQA
L
TGT
N
T
---
GGA
I
--
D
G
V
S
T
TD
------------------
R
S
P
Y
SK
AE
I
F
S
L
F
A
EN
N
ME
LTD
S
T
I
V
T
P
GLRFD
H
H
SIVGN
N
WS
PALNISQGL
GD
D
-
---F
T
LKM
G
I
A
RA
----------------
Y
KA
P
S
LY
Q
TN
P
N
--
-
YI
L
Y
S
----
-
K
G
Q
G
CY
A
--
S
AG
GCYLQGND
D
L
KAE
T
SIN
K
EIG
L
EFK
RD
G
-
-
W
L
AG
V
T
W
FR
N
D
YR
NKIE
A
G
Y
V
AV
G
QN
AV
GT
DLYQ
W
D
N
V
P
KA
V
VEG
L
E
G
S
LN---V
P
-
VSE
TVM
W
TN
N
I
T
Y
MLK
S
E
N
K
T
T
----
-
-
-----
GDRL
S
II
PEY
TLN
S
TLSW
QA
RE
D
L
S
M
Q
TTF
T
W
YG
KQQ
P
KKY
-
N
Y
KG
QPAVG
P
ETKEIS
P
-
Y
SIV
G
L
S
AT
W
D
VTKN
V
S
LTGG
VDNLFD
K
R
L
WRAGNA
Q
T
T
G
DLA
GANY
I
A
GA
G
AYT
Y
N
-
E
PG
--
RT
WY
M
SV
NTHF
fig|316385.7.peg.545
Escherichia coli str. K-12 substr. DH10B
MNKKIHSL
A
LLVNL
G
IYGVA
--
-
Q
A
Q
EP
TD
TPVSH
DDT
I
VVTA
-
A
E
Q
N
L
-
Q
AP
GV
S
---
-------------
T
I
T
A
DEIR
K
N
P
V
A
R
DVS
K
II
R
T
MPGVN
L
---
--
TGNST
S
G
Q
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
K
P
VS
S
R
NSV
RQGW
RGE
RDT
RG
DTSWVPPEM
I
E
R
I
EVLRGP
A
AA
R
YG
N
G
A
A
GG
V
V
NIITK
KG
SGEWH
G
SW
D
A
Y
F
NA
PE
H
KEEGATK
R
TN
FSLTGP
L
-
GD
EFSF
RLYG
NLD
--
KT
Q
A
D
AWD
IN
Q
--
G
HQSAR
AGTYATTLP
AGR
EG
V
I
N
K
DINGV
VR
WDF
AP
LQ
S
LELEA
G
YSRQGN
L
-
Y
AGD
TQ
NTNS
D
---------------
SY
T
RS
--
KY
G
D
-
E
T
NRL
Y
RQ
NY
A
LTWN
GG
WD
N
G
V
T
T
S
NWVQY
EH
-----------
TR
N
SR
IP
E
-
----
G
LA
G
-----
G
TEGKFNEK
A
TQDFVDI
D
L
D
D
V
M
L
H
SEV
N
-
-
-
LPIDF
L
V
--
NQT
----
--
--
--
--
--
LT
L
G
T
EWNQQ
R
M
KDLSS
N
TQA
L
TGT
N
T
---
GGA
I
--
D
G
V
S
T
TD
------------------
R
S
P
Y
SK
AE
I
F
S
L
F
A
EN
N
ME
LTD
S
T
I
V
T
P
GLRFD
H
H
SIVGN
N
WS
PALNISQGL
GD
D
-
---F
T
LKM
G
I
A
RA
----------------
Y
KA
P
S
LY
Q
TN
P
N
--
-
YI
L
Y
S
----
-
K
G
Q
G
CY
A
--
S
AG
GCYLQGND
D
L
KAE
T
SIN
K
EIG
L
EFK
RD
G
-
-
W
L
AG
V
T
W
FR
N
D
YR
NKIE
A
G
Y
V
AV
G
QN
AV
GT
DLYQ
W
D
N
V
P
KA
V
VEG
L
E
G
S
LN---V
P
-
VSE
TVM
W
TN
N
I
T
Y
MLK
S
E
N
K
T
T
----
-
-
-----
GDRL
S
II
PEY
TLN
S
TLSW
QA
RE
D
L
S
M
Q
TTF
T
W
YG
KQQ
P
KKY
-
N
Y
KG
QPAVG
P
ETKEIS
P
-
Y
SIV
G
L
S
AT
W
D
VTKN
V
S
LTGG
VDNLFD
K
R
L
WRAGNA
Q
T
T
G
DLA
GANY
I
A
GA
G
AYT
Y
N
-
E
PG
--
RT
WY
M
SV
NTHF
fig|316385.7.peg.656
Escherichia coli str. K-12 substr. DH10B
MNKKIHSL
A
LLVNL
G
IYGVA
--
-
Q
A
Q
EP
TD
TPVSH
DDT
I
VVTA
-
A
E
Q
N
L
-
Q
AP
GV
S
---
-------------
T
I
T
A
DEIR
K
N
P
V
A
R
DVS
K
II
R
T
MPGVN
L
---
--
TGNST
S
G
Q
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
K
P
VS
S
R
NSV
RQGW
RGE
RDT
RG
DTSWVPPEM
I
E
R
I
EVLRGP
A
AA
R
YG
N
G
A
A
GG
V
V
NIITK
KG
SGEWH
G
SW
D
A
Y
F
NA
PE
H
KEEGATK
R
TN
FSLTGP
L
-
GD
EFSF
RLYG
NLD
--
KT
Q
A
D
AWD
IN
Q
--
G
HQSAR
AGTYATTLP
AGR
EG
V
I
N
K
DINGV
VR
WDF
AP
LQ
S
LELEA
G
YSRQGN
L
-
Y
AGD
TQ
NTNS
D
---------------
SY
T
RS
--
KY
G
D
-
E
T
NRL
Y
RQ
NY
A
LTWN
GG
WD
N
G
V
T
T
S
NWVQY
EH
-----------
TR
N
SR
IP
E
-
----
G
LA
G
-----
G
TEGKFNEK
A
TQDFVDI
D
L
D
D
V
M
L
H
SEV
N
-
-
-
LPIDF
L
V
--
NQT
----
--
--
--
--
--
LT
L
G
T
EWNQQ
R
M
KDLSS
N
TQA
L
TGT
N
T
---
GGA
I
--
D
G
V
S
T
TD
------------------
R
S
P
Y
SK
AE
I
F
S
L
F
A
EN
N
ME
LTD
S
T
I
V
T
P
GLRFD
H
H
SIVGN
N
WS
PALNISQGL
GD
D
-
---F
T
LKM
G
I
A
RA
----------------
Y
KA
P
S
LY
Q
TN
P
N
--
-
YI
L
Y
S
----
-
K
G
Q
G
CY
A
--
S
AG
GCYLQGND
D
L
KAE
T
SIN
K
EIG
L
EFK
RD
G
-
-
W
L
AG
V
T
W
FR
N
D
YR
NKIE
A
G
Y
V
AV
G
QN
AV
GT
DLYQ
W
D
N
V
P
KA
V
VEG
L
E
G
S
LN---V
P
-
VSE
TVM
W
TN
N
I
T
Y
MLK
S
E
N
K
T
T
----
-
-
-----
GDRL
S
II
PEY
TLN
S
TLSW
QA
RE
D
L
S
M
Q
TTF
T
W
YG
KQQ
P
KKY
-
N
Y
KG
QPAVG
P
ETKEIS
P
-
Y
SIV
G
L
S
AT
W
D
VTKN
V
S
LTGG
VDNLFD
K
R
L
WRAGNA
Q
T
T
G
DLA
GANY
I
A
GA
G
AYT
Y
N
-
E
PG
--
RT
WY
M
SV
NTHF
fig|511145.12.peg.609
Escherichia coli str. K-12 substr. MG1655
MNKKIHSL
A
LLVNL
G
IYGVA
--
-
Q
A
Q
EP
TD
TPVSH
DDT
I
VVTA
-
A
E
Q
N
L
-
Q
AP
GV
S
---
-------------
T
I
T
A
DEIR
K
N
P
V
A
R
DVS
K
II
R
T
MPGVN
L
---
--
TGNST
S
G
Q
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
K
P
VS
S
R
NSV
RQGW
RGE
RDT
RG
DTSWVPPEM
I
E
R
I
EVLRGP
A
AA
R
YG
N
G
A
A
GG
V
V
NIITK
KG
SGEWH
G
SW
D
A
Y
F
NA
PE
H
KEEGATK
R
TN
FSLTGP
L
-
GD
EFSF
RLYG
NLD
--
KT
Q
A
D
AWD
IN
Q
--
G
HQSAR
AGTYATTLP
AGR
EG
V
I
N
K
DINGV
VR
WDF
AP
LQ
S
LELEA
G
YSRQGN
L
-
Y
AGD
TQ
NTNS
D
---------------
SY
T
RS
--
KY
G
D
-
E
T
NRL
Y
RQ
NY
A
LTWN
GG
WD
N
G
V
T
T
S
NWVQY
EH
-----------
TR
N
SR
IP
E
-
----
G
LA
G
-----
G
TEGKFNEK
A
TQDFVDI
D
L
D
D
V
M
L
H
SEV
N
-
-
-
LPIDF
L
V
--
NQT
----
--
--
--
--
--
LT
L
G
T
EWNQQ
R
M
KDLSS
N
TQA
L
TGT
N
T
---
GGA
I
--
D
G
V
S
T
TD
------------------
R
S
P
Y
SK
AE
I
F
S
L
F
A
EN
N
ME
LTD
S
T
I
V
T
P
GLRFD
H
H
SIVGN
N
WS
PALNISQGL
GD
D
-
---F
T
LKM
G
I
A
RA
----------------
Y
KA
P
S
LY
Q
TN
P
N
--
-
YI
L
Y
S
----
-
K
G
Q
G
CY
A
--
S
AG
GCYLQGND
D
L
KAE
T
SIN
K
EIG
L
EFK
RD
G
-
-
W
L
AG
V
T
W
FR
N
D
YR
NKIE
A
G
Y
V
AV
G
QN
AV
GT
DLYQ
W
D
N
V
P
KA
V
VEG
L
E
G
S
LN---V
P
-
VSE
TVM
W
TN
N
I
T
Y
MLK
S
E
N
K
T
T
----
-
-
-----
GDRL
S
II
PEY
TLN
S
TLSW
QA
RE
D
L
S
M
Q
TTF
T
W
YG
KQQ
P
KKY
-
N
Y
KG
QPAVG
P
ETKEIS
P
-
Y
SIV
G
L
S
AT
W
D
VTKN
V
S
LTGG
VDNLFD
K
R
L
WRAGNA
Q
T
T
G
DLA
GANY
I
A
GA
G
AYT
Y
N
-
E
PG
--
RT
WY
M
SV
NTHF
fig|511145.6.peg.600
Escherichia coli str. K-12 substr. MG1655
MNKKIHSL
A
LLVNL
G
IYGVA
--
-
Q
A
Q
EP
TD
TPVSH
DDT
I
VVTA
-
A
E
Q
N
L
-
Q
AP
GV
S
---
-------------
T
I
T
A
DEIR
K
N
P
V
A
R
DVS
K
II
R
T
MPGVN
L
---
--
TGNST
S
G
Q
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
K
P
VS
S
R
NSV
RQGW
RGE
RDT
RG
DTSWVPPEM
I
E
R
I
EVLRGP
A
AA
R
YG
N
G
A
A
GG
V
V
NIITK
KG
SGEWH
G
SW
D
A
Y
F
NA
PE
H
KEEGATK
R
TN
FSLTGP
L
-
GD
EFSF
RLYG
NLD
--
KT
Q
A
D
AWD
IN
Q
--
G
HQSAR
AGTYATTLP
AGR
EG
V
I
N
K
DINGV
VR
WDF
AP
LQ
S
LELEA
G
YSRQGN
L
-
Y
AGD
TQ
NTNS
D
---------------
SY
T
RS
--
KY
G
D
-
E
T
NRL
Y
RQ
NY
A
LTWN
GG
WD
N
G
V
T
T
S
NWVQY
EH
-----------
TR
N
SR
IP
E
-
----
G
LA
G
-----
G
TEGKFNEK
A
TQDFVDI
D
L
D
D
V
M
L
H
SEV
N
-
-
-
LPIDF
L
V
--
NQT
----
--
--
--
--
--
LT
L
G
T
EWNQQ
R
M
KDLSS
N
TQA
L
TGT
N
T
---
GGA
I
--
D
G
V
S
T
TD
------------------
R
S
P
Y
SK
AE
I
F
S
L
F
A
EN
N
ME
LTD
S
T
I
V
T
P
GLRFD
H
H
SIVGN
N
WS
PALNISQGL
GD
D
-
---F
T
LKM
G
I
A
RA
----------------
Y
KA
P
S
LY
Q
TN
P
N
--
-
YI
L
Y
S
----
-
K
G
Q
G
CY
A
--
S
AG
GCYLQGND
D
L
KAE
T
SIN
K
EIG
L
EFK
RD
G
-
-
W
L
AG
V
T
W
FR
N
D
YR
NKIE
A
G
Y
V
AV
G
QN
AV
GT
DLYQ
W
D
N
V
P
KA
V
VEG
L
E
G
S
LN---V
P
-
VSE
TVM
W
TN
N
I
T
Y
MLK
S
E
N
K
T
T
----
-
-
-----
GDRL
S
II
PEY
TLN
S
TLSW
QA
RE
D
L
S
M
Q
TTF
T
W
YG
KQQ
P
KKY
-
N
Y
KG
QPAVG
P
ETKEIS
P
-
Y
SIV
G
L
S
AT
W
D
VTKN
V
S
LTGG
VDNLFD
K
R
L
WRAGNA
Q
T
T
G
DLA
GANY
I
A
GA
G
AYT
Y
N
-
E
PG
--
RT
WY
M
SV
NTHF
fig|344610.3.peg.1570
Escherichia coli 53638
MNKKIHSL
A
LLVNL
G
IYG
G
A
--
-
Q
A
Q
EP
TD
TPVSH
DDT
I
VVTA
-
A
E
Q
N
L
-
Q
AP
GV
S
---
-------------
T
I
T
A
DEIR
K
N
P
V
A
R
DVS
E
II
R
T
MPGVN
L
---
--
TGNST
S
G
Q
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
K
P
VS
S
R
NSV
RQGW
RGE
RDT
RG
DTSWVPPEM
I
E
R
I
EVLRGP
A
AA
R
YG
N
G
A
A
GG
V
V
NIITK
KG
SGEWH
G
SW
D
A
Y
F
NA
PE
H
KEEGATK
R
TN
FSLTGP
L
-
GD
EFSF
RLYG
NLD
--
KT
Q
A
D
AWD
IN
Q
--
G
HQSAR
AGTYATTLP
AGR
EG
V
I
N
K
DINGV
VR
WDF
AP
LQ
S
LELEA
G
YSRQGN
L
-
Y
AGD
TQ
NTNS
D
---------------
AY
T
RS
--
KY
G
D
-
E
T
NRL
Y
RQ
NY
S
LTWN
GG
WD
N
G
V
T
T
S
NWVQY
EH
-----------
TR
N
SR
IP
E
-
----
G
LA
G
-----
G
TEGKFNEK
A
TQDFVDI
D
L
D
D
V
M
L
H
SEV
N
-
-
-
LPIDF
L
V
--
NQT
----
--
--
--
--
--
LT
L
G
T
EWNQQ
R
M
KDLSS
N
TQA
L
TGT
N
T
---
GGA
I
--
D
G
V
S
A
TD
------------------
R
S
P
Y
SK
AE
I
F
S
L
F
A
EN
N
ME
LTD
S
T
I
V
T
P
GLRFD
H
H
SIVGN
N
WS
PALNISQGL
GD
D
-
---F
T
LKM
G
I
A
RA
----------------
Y
KA
P
S
LY
Q
TN
P
N
--
-
YI
L
Y
S
----
-
K
G
Q
G
CY
A
--
S
AG
GCYLQGND
D
L
KAE
T
SIN
K
EIG
L
EFK
RD
G
-
-
W
L
AG
V
T
W
FR
N
D
YR
NKIE
A
G
Y
V
AV
G
QN
AV
GT
DLYQ
W
D
N
V
P
KA
V
VEG
L
E
G
S
LN---V
P
-
VSE
TVM
W
TN
N
I
T
Y
MLK
S
E
N
K
T
T
----
-
-
-----
GDRL
S
II
PEY
TLN
S
TLSW
QA
RE
D
L
S
M
Q
TTF
T
W
YG
KQQ
P
KKY
-
N
Y
KG
QPAVG
P
ETKEIS
P
-
Y
SIV
G
L
S
AT
W
D
VTKN
V
S
LTGG
VDNLFD
K
R
L
WRAGNA
Q
T
T
G
DLA
GANY
I
A
GA
G
AYT
Y
N
-
E
PG
--
RT
WY
M
SV
NTHF
fig|344610.7.peg.1109
Escherichia coli 53638
MNKKIHSL
A
LLVNL
G
IYG
G
A
--
-
Q
A
Q
EP
TD
TPVSH
DDT
I
VVTA
-
A
E
Q
N
L
-
Q
AP
GV
S
---
-------------
T
I
T
A
DEIR
K
N
P
V
A
R
DVS
E
II
R
T
MPGVN
L
---
--
TGNST
S
G
Q
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
K
P
VS
S
R
NSV
RQGW
RGE
RDT
RG
DTSWVPPEM
I
E
R
I
EVLRGP
A
AA
R
YG
N
G
A
A
GG
V
V
NIITK
KG
SGEWH
G
SW
D
A
Y
F
NA
PE
H
KEEGATK
R
TN
FSLTGP
L
-
GD
EFSF
RLYG
NLD
--
KT
Q
A
D
AWD
IN
Q
--
G
HQSAR
AGTYATTLP
AGR
EG
V
I
N
K
DINGV
VR
WDF
AP
LQ
S
LELEA
G
YSRQGN
L
-
Y
AGD
TQ
NTNS
D
---------------
AY
T
RS
--
KY
G
D
-
E
T
NRL
Y
RQ
NY
S
LTWN
GG
WD
N
G
V
T
T
S
NWVQY
EH
-----------
TR
N
SR
IP
E
-
----
G
LA
G
-----
G
TEGKFNEK
A
TQDFVDI
D
L
D
D
V
M
L
H
SEV
N
-
-
-
LPIDF
L
V
--
NQT
----
--
--
--
--
--
LT
L
G
T
EWNQQ
R
M
KDLSS
N
TQA
L
TGT
N
T
---
GGA
I
--
D
G
V
S
A
TD
------------------
R
S
P
Y
SK
AE
I
F
S
L
F
A
EN
N
ME
LTD
S
T
I
V
T
P
GLRFD
H
H
SIVGN
N
WS
PALNISQGL
GD
D
-
---F
T
LKM
G
I
A
RA
----------------
Y
KA
P
S
LY
Q
TN
P
N
--
-
YI
L
Y
S
----
-
K
G
Q
G
CY
A
--
S
AG
GCYLQGND
D
L
KAE
T
SIN
K
EIG
L
EFK
RD
G
-
-
W
L
AG
V
T
W
FR
N
D
YR
NKIE
A
G
Y
V
AV
G
QN
AV
GT
DLYQ
W
D
N
V
P
KA
V
VEG
L
E
G
S
LN---V
P
-
VSE
TVM
W
TN
N
I
T
Y
MLK
S
E
N
K
T
T
----
-
-
-----
GDRL
S
II
PEY
TLN
S
TLSW
QA
RE
D
L
S
M
Q
TTF
T
W
YG
KQQ
P
KKY
-
N
Y
KG
QPAVG
P
ETKEIS
P
-
Y
SIV
G
L
S
AT
W
D
VTKN
V
S
LTGG
VDNLFD
K
R
L
WRAGNA
Q
T
T
G
DLA
GANY
I
A
GA
G
AYT
Y
N
-
E
PG
--
RT
WY
M
SV
NTHF
fig|439855.10.peg.772
Escherichia coli SMS-3-5
MNKKIHSL
A
LLVNL
G
IYGVA
--
-
Q
A
Q
EP
TD
TPVSH
DDT
I
VVTA
-
A
E
Q
N
L
-
Q
AP
GV
S
---
-------------
T
I
T
A
DEIR
K
N
P
V
A
R
DVS
E
II
R
T
MPGVN
L
---
--
TGNST
S
G
Q
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
K
P
VS
S
R
NSV
RQGW
RGE
RDT
RG
DTSWVPPEM
I
E
R
I
EVLRGP
A
AA
R
YG
N
G
A
A
GG
V
V
NIITK
KG
SGEWH
G
SW
D
A
Y
F
NA
PE
H
KEEGATK
R
TN
FSLTGP
L
-
GD
EFSF
RLYG
NLD
--
KT
Q
A
D
AWD
IN
Q
--
G
HQSAR
AGTYATTLP
AGR
EG
V
I
N
K
DINGV
VR
WDF
AP
LQ
S
LELEA
G
YSRQGN
L
-
Y
AGD
TQ
NTNS
D
---------------
AY
T
RS
--
KY
G
D
-
E
T
NRL
Y
RQ
NY
S
LTWN
GG
WD
N
G
V
T
T
S
NWVQY
EH
-----------
TR
N
SR
IP
E
-
----
G
LA
G
-----
G
TEGKFNEK
A
AQDFVDI
D
L
D
D
V
M
L
H
SEV
N
-
-
-
LPIDF
L
V
--
NQT
----
--
--
--
--
--
LT
L
G
T
EWNQQ
R
M
KDLSS
N
TQA
L
TGT
N
T
---
GGA
I
--
D
G
V
S
A
TD
------------------
R
S
P
Y
SK
AE
I
F
S
L
F
A
EN
N
ME
LTD
S
T
I
V
T
P
GLRFD
H
H
SIVGN
N
WS
PALNISQGL
GD
D
-
---F
T
LKM
G
I
A
RA
----------------
Y
KA
P
S
LY
Q
TN
P
N
--
-
YI
L
Y
S
----
-
K
G
Q
G
CY
A
--
S
AG
GCYLQGND
D
L
KAE
T
SIN
K
EIG
L
EFK
RD
G
-
-
W
L
AG
V
T
W
FR
N
D
YR
NKIE
A
G
Y
V
AV
G
QN
AA
GT
DLYQ
W
D
N
V
P
KA
V
VEG
L
E
G
S
LN---V
P
-
VSE
TVM
W
TN
N
I
T
Y
MLK
S
E
N
K
T
T
----
-
-
-----
GDRL
S
II
PEY
TLN
S
TLSW
QA
RE
D
L
S
M
Q
TTF
T
W
YG
KQQ
P
KKY
-
N
Y
KG
QPAVG
P
ETKEIS
P
-
Y
SIV
G
L
S
AT
W
D
VTKN
V
S
LTGG
VDNLFD
K
R
L
WRAGNA
Q
T
T
G
DLA
GANY
I
A
GA
G
AYT
Y
N
-
E
PG
--
RT
WY
M
SV
NTHF
fig|749538.3.peg.4166
Escherichia coli MS 116-1
MNKKIHSL
A
LLVNL
G
IYGVA
--
-
Q
A
Q
EP
TD
TPVSH
DDT
I
VVTA
-
A
E
Q
N
L
-
Q
AP
GV
S
---
-------------
T
I
T
A
DEIR
K
N
P
V
A
R
DVS
E
II
R
T
MPGVN
L
---
--
TGNST
S
G
Q
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
K
P
VS
S
R
NSV
RQGW
RGE
RDT
RG
DTSWVPPEM
I
E
R
I
EVLRGP
A
AA
R
YG
N
G
A
A
GG
V
V
NIITK
KG
SGEWH
G
SW
D
A
Y
F
NA
PE
H
KEEGATK
R
TN
FSLTGP
L
-
GD
EFSF
RLYG
NLD
--
KT
Q
A
D
AWD
IN
Q
--
G
HQSAR
AGTYATTLP
AGR
EG
V
I
N
K
DINGV
VR
WDF
AP
LQ
S
LELEA
G
YSRQGN
L
-
Y
AGD
TQ
NTNS
D
---------------
SY
P
RS
--
KY
G
D
-
E
T
NRL
Y
RQ
NY
A
LTWN
GG
WD
N
G
V
T
T
S
NWVQY
EH
-----------
TR
N
SR
IP
E
-
----
G
LA
G
-----
G
TEGKFNEK
A
TQDFVDI
D
L
D
D
V
M
L
H
SEV
N
-
-
-
LPIDF
L
V
--
NQT
----
--
--
--
--
--
LT
L
G
T
EWNQQ
R
M
KDLSS
N
TQA
L
TGT
N
T
---
GGA
I
--
D
G
V
S
T
TD
------------------
R
S
P
Y
SK
AE
I
F
S
L
F
A
EN
N
ME
LTD
S
T
I
V
T
P
GLRFD
H
H
SIVGN
N
WS
PALNISQGL
GD
D
-
---F
T
LKM
G
I
A
RA
----------------
Y
KA
P
S
LY
Q
TN
P
N
--
-
YI
L
Y
S
----
-
K
G
Q
G
CY
A
--
S
AG
GCYLQGND
D
L
KAE
T
SIN
K
EIG
L
EFK
RD
G
-
-
W
L
AG
V
T
W
FR
N
D
YR
NKIE
A
G
Y
V
AV
G
QN
AV
GT
DLYQ
W
D
N
V
P
KA
V
VEG
L
E
G
S
LN---V
P
-
VSE
TVM
W
TN
N
I
T
Y
MLK
S
E
N
K
T
T
----
-
-
-----
GDRL
S
II
PEY
TLN
S
TLSW
QA
RE
D
L
S
M
Q
TTF
T
W
YG
KQQ
P
KKY
-
N
Y
KG
QPAVG
P
ETKEIS
P
-
Y
SIV
G
L
S
AT
W
D
VTKN
V
S
LTGG
VDNLFD
K
R
L
WRAGNA
Q
T
T
G
DLA
GANY
I
A
GA
G
AYT
Y
N
-
E
PG
--
RT
WY
M
SV
NTHF
fig|670897.3.peg.162
Escherichia coli 2362-75
MNKKIHSL
A
LLVNL
G
IYGVA
--
-
Q
A
Q
EP
TD
TPVSH
DDT
I
VVTA
-
A
E
Q
N
L
-
Q
AP
GV
S
---
-------------
T
I
T
A
DEIR
K
N
P
V
A
R
DVS
E
II
R
T
MPGVN
L
---
--
TGNST
S
G
Q
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
K
P
VS
S
R
NSV
RQGW
RGE
RDT
RG
DTSWVPPEM
I
E
R
I
EVLRGP
A
AA
R
YG
N
G
A
A
GG
V
V
NIITK
KG
SGEWH
G
SW
D
A
Y
F
NA
PE
H
KEEGATK
R
TN
FSLTGP
L
-
GD
EFSF
RLYG
NLD
--
KT
Q
A
D
AWD
IN
Q
--
G
HQSAR
AGTYATTLP
AGR
EG
V
I
N
K
DINGV
VR
WDF
AP
LQ
S
LELEA
G
YSRQGN
L
-
Y
AGD
TQ
NTNS
D
---------------
AY
T
RS
--
KY
G
D
-
E
T
NRL
Y
RQ
NY
S
LTWN
GG
WD
N
G
V
T
T
S
NWVQY
EH
-----------
TR
N
SR
IP
E
-
----
G
LA
G
-----
G
TEGKFNEK
A
AQDFVDI
D
L
D
D
V
M
L
H
SEV
N
-
-
-
LPIDF
L
V
--
NQT
----
--
--
--
--
--
LT
L
G
T
EWNQQ
R
M
KDLSS
N
TQA
L
TGT
N
T
---
GGA
I
--
D
G
V
S
A
TD
------------------
R
S
P
Y
SK
AE
I
F
S
L
F
A
EN
N
ME
LTD
S
T
I
V
T
P
GLRFD
H
H
SIVGN
N
WS
PALNISQGL
G
Y
D
-
---F
T
LKM
G
I
A
RA
----------------
Y
KA
P
S
LY
Q
TN
P
N
--
-
YI
L
Y
S
----
-
K
G
Q
G
CY
A
--
S
AG
GCYLQGND
D
L
KAE
T
SIN
K
EIG
L
EFK
RD
G
-
-
W
L
AG
V
T
W
FR
N
D
YR
NKIE
A
G
Y
V
AV
G
QN
AV
GT
DLYQ
W
D
N
V
P
KA
V
VEG
L
E
G
S
LN---V
P
-
VSE
TVM
W
TN
N
I
T
Y
MLK
S
E
N
K
T
T
----
-
-
-----
GDRL
S
II
PEY
TLN
S
TLSW
QA
RE
D
L
S
M
Q
TTF
T
W
YG
KQQ
P
KKY
-
N
Y
KG
QPAVG
P
ETKEIS
P
-
Y
SIV
G
L
S
AT
W
D
VTKN
V
S
LTGG
VDNLFD
K
R
L
WRAGNA
Q
T
T
G
DLA
GANY
I
A
GA
G
AYT
Y
N
-
E
PG
--
RT
WY
M
SI
NTHF
fig|585035.6.peg.618
Escherichia coli S88
MNKKIHSL
A
LLVNL
G
IYGVA
--
-
Q
A
Q
EP
TD
TPVSH
DDT
I
VVTA
-
A
E
Q
N
L
-
Q
AP
GV
S
---
-------------
T
I
T
A
DEIR
K
N
P
V
A
R
DVS
E
II
R
T
MPGVN
L
---
--
TGNST
S
G
Q
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
K
P
VS
S
R
NSV
RQGW
RGE
RDT
RG
DTSWVPPEM
I
E
R
I
EVLRGP
A
AA
R
YG
N
G
A
A
GG
V
V
NIITK
KG
SGEWH
G
SW
D
A
Y
F
NA
PE
H
KEEGATK
R
TN
FSLTGP
L
-
GD
EFSF
RLYG
NLD
--
KT
Q
A
D
AWD
IN
Q
--
G
HQSAR
AGTYATTLP
AGR
EG
V
I
N
K
DINGV
VR
WDF
AP
LQ
S
LELEA
G
YSRQGN
L
-
Y
AGD
TQ
NTNS
D
---------------
AY
T
RS
--
KY
G
Y
-
E
T
NRL
Y
RQ
NY
S
LTWN
GG
WD
N
G
V
T
T
S
NWVQY
EH
-----------
TR
N
SR
IP
E
-
----
G
LA
G
-----
G
TEGKFNEK
A
AQDFVDI
D
L
D
D
V
M
L
H
SEV
N
-
-
-
LPIDF
L
V
--
NQT
----
--
--
--
--
--
LT
L
G
T
EWNQQ
R
M
KDLSS
N
TQA
L
TGT
N
T
---
GGA
I
--
D
G
V
S
A
TD
------------------
R
S
P
Y
SK
AE
I
F
S
L
F
A
EN
N
ME
LTD
S
T
I
V
T
P
GLRFD
H
H
SIVGN
N
WS
PALNISQGL
GD
D
-
---F
T
LKM
G
I
A
RA
----------------
Y
KA
P
S
LY
Q
TN
P
N
--
-
YI
L
Y
S
----
-
K
G
Q
G
CY
A
--
S
AG
GCYLQGND
D
L
KAE
T
SIN
K
EIG
L
EFK
RD
G
-
-
W
L
AG
V
T
W
FR
N
D
YR
NKIE
A
G
Y
V
AV
G
QN
AV
GT
DLYQ
W
D
N
V
P
KA
V
VEG
L
E
G
S
LN---V
P
-
VSE
TVM
W
TN
N
I
T
Y
MLK
S
E
N
K
T
T
----
-
-
-----
GDRL
S
II
PEY
TLN
S
TLSW
QA
RE
D
L
S
M
Q
TTF
T
W
YG
KQQ
P
KKY
-
N
Y
KG
QPAVG
P
ETKEIS
P
-
Y
SIV
G
L
S
AT
W
D
VTKN
V
S
LTGG
VDNLFD
K
R
L
WRAGNA
Q
T
T
G
DLA
GANY
I
A
GA
G
AYT
Y
N
-
E
PG
--
RT
WY
M
SI
NTHF
fig|562.371.peg.2839
Escherichia coli 1044A
MNKKIHSL
A
LLVNL
G
IYGVA
--
-
Q
A
Q
EP
TD
TPVSH
DDT
I
VVTA
-
A
E
Q
N
L
-
Q
AP
GV
S
---
-------------
T
I
T
A
DEIR
K
N
P
V
A
R
DVS
E
II
R
T
MPGVN
L
---
--
TGNST
S
G
Q
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
K
P
VS
S
R
NSV
RQGW
RGE
RDT
RG
DTSWVPPEM
I
E
R
I
EVLRGP
A
AA
R
YG
N
G
A
A
GG
V
V
NIITK
KG
SGEWH
G
SW
D
A
Y
F
NA
PE
H
KEEGATK
R
TN
FSLTGP
L
-
GD
EFSF
RLYG
NLD
--
KT
Q
A
D
AWD
IN
Q
--
G
HQSAR
AGTYATTLP
AGR
EG
V
I
N
K
DINGV
VR
WDF
AP
LQ
S
LELEA
G
YSRQGN
L
-
Y
AGD
TQ
NTNS
D
---------------
AY
T
RS
--
KY
G
D
-
E
T
NRL
Y
RQ
NY
S
LTWN
GG
WD
N
G
V
T
T
S
NWVQY
EH
-----------
TR
N
SR
IP
E
-
----
G
LA
G
-----
G
TEGKFNEK
A
TQDFVDN
D
L
D
D
V
M
L
H
SEV
N
-
-
-
LPIDF
L
V
--
NQT
----
--
--
--
--
--
LT
L
G
T
EWNQQ
R
M
KDLSS
N
TQA
L
TGT
N
T
---
GGA
I
--
D
G
V
S
A
TD
------------------
R
S
P
Y
SK
AE
I
F
S
L
F
A
EN
N
ME
LTD
S
T
I
V
T
P
GLRFD
H
H
SIVGN
N
WS
PALNISQGL
GD
D
-
---F
T
LKM
G
I
A
RA
----------------
Y
KA
P
S
LY
Q
TN
P
N
--
-
YI
L
Y
S
----
-
K
G
Q
G
CY
A
--
S
AG
GCYLQGND
D
L
KAE
T
SIN
K
EIG
L
EFK
RD
G
-
-
W
L
AG
I
T
W
FR
N
D
YR
NKIE
A
G
Y
V
AV
G
QN
AV
GT
DLYQ
W
D
N
V
P
KA
V
VEG
L
E
G
S
LN---V
P
-
VSE
TVM
W
TN
N
I
T
Y
MLK
S
E
N
K
T
T
----
-
-
-----
GDRL
S
II
PEY
TLN
S
TLSW
QA
RE
D
L
S
M
Q
TTF
T
W
YG
KQQ
P
KKY
-
N
Y
KG
QPAVG
P
ETKEIS
P
-
Y
SIV
G
L
S
AT
W
D
VTKN
V
S
LTGG
VDNLFD
K
R
L
WRAGNA
Q
T
T
G
DLA
GANY
I
A
GA
G
AYT
Y
N
-
E
PG
--
RT
WY
M
SV
NTHF
fig|562.373.peg.3154
Escherichia coli 1125A
MNKKIHSL
A
LLVNL
G
IYGVA
--
-
Q
A
Q
EP
TD
TPVSH
DDT
I
VVTA
-
A
E
Q
N
L
-
Q
AP
GV
S
---
-------------
T
I
T
A
DEIR
K
N
P
V
A
R
DVS
E
II
R
T
MPGVN
L
---
--
TGNST
S
G
Q
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
K
P
VS
S
R
NSV
RQGW
RGE
RDT
RG
DTSWVPPEM
I
E
R
I
EVLRGP
A
AA
R
YG
N
G
A
A
GG
V
V
NIITK
KG
SGEWH
G
SW
D
A
Y
F
NA
PE
H
KEEGATK
R
TN
FSLTGP
L
-
GD
EFSF
RLYG
NLD
--
KT
Q
A
D
AWD
IN
Q
--
G
HQSAR
AGTYATTLP
AGR
EG
V
I
N
K
DINGV
VR
WDF
AP
LQ
S
LELEA
G
YSRQGN
L
-
Y
AGD
TQ
NTNS
D
---------------
AY
T
RS
--
KY
G
D
-
E
T
NRL
Y
RQ
NY
S
LTWN
GG
WD
N
G
V
T
T
S
NWVQY
EH
-----------
TR
N
SR
IP
E
-
----
G
LA
G
-----
G
TEGKFNEK
A
TQDFVDN
D
L
D
D
V
M
L
H
SEV
N
-
-
-
LPIDF
L
V
--
NQT
----
--
--
--
--
--
LT
L
G
T
EWNQQ
R
M
KDLSS
N
TQA
L
TGT
N
T
---
GGA
I
--
D
G
V
S
A
TD
------------------
R
S
P
Y
SK
AE
I
F
S
L
F
A
EN
N
ME
LTD
S
T
I
V
T
P
GLRFD
H
H
SIVGN
N
WS
PALNISQGL
GD
D
-
---F
T
LKM
G
I
A
RA
----------------
Y
KA
P
S
LY
Q
TN
P
N
--
-
YI
L
Y
S
----
-
K
G
Q
G
CY
A
--
S
AG
GCYLQGND
D
L
KAE
T
SIN
K
EIG
L
EFK
RD
G
-
-
W
L
AG
I
T
W
FR
N
D
YR
NKIE
A
G
Y
V
AV
G
QN
AV
GT
DLYQ
W
D
N
V
P
KA
V
VEG
L
E
G
S
LN---V
P
-
VSE
TVM
W
TN
N
I
T
Y
MLK
S
E
N
K
T
T
----
-
-
-----
GDRL
S
II
PEY
TLN
S
TLSW
QA
RE
D
L
S
M
Q
TTF
T
W
YG
KQQ
P
KKY
-
N
Y
KG
QPAVG
P
ETKEIS
P
-
Y
SIV
G
L
S
AT
W
D
VTKN
V
S
LTGG
VDNLFD
K
R
L
WRAGNA
Q
T
T
G
DLA
GANY
I
A
GA
G
AYT
Y
N
-
E
PG
--
RT
WY
M
SV
NTHF
fig|562.372.peg.1570
Escherichia coli 1212A
MNKKIHSL
A
LLVNL
G
IYGVA
--
-
Q
A
Q
EP
TD
TPVSH
DDT
I
VVTA
-
A
E
Q
N
L
-
Q
AP
GV
S
---
-------------
T
I
T
A
DEIR
K
N
P
V
A
R
DVS
E
II
R
T
MPGVN
L
---
--
TGNST
S
G
Q
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
K
P
VS
S
R
NSV
RQGW
RGE
RDT
RG
DTSWVPPEM
I
E
R
I
EVLRGP
A
AA
R
YG
N
G
A
A
GG
V
V
NIITK
KG
SGEWH
G
SW
D
A
Y
F
NA
PE
H
KEEGATK
R
TN
FSLTGP
L
-
GD
EFSF
RLYG
NLD
--
KT
Q
A
D
AWD
IN
Q
--
G
HQSAR
AGTYATTLP
AGR
EG
V
I
N
K
DINGV
VR
WDF
AP
LQ
S
LELEA
G
YSRQGN
L
-
Y
AGD
TQ
NTNS
D
---------------
AY
T
RS
--
KY
G
D
-
E
T
NRL
Y
RQ
NY
S
LTWN
GG
WD
N
G
V
T
T
S
NWVQY
EH
-----------
TR
N
SR
IP
E
-
----
G
LA
G
-----
G
TEGKFNEK
A
TQDFVDN
D
L
D
D
V
M
L
H
SEV
N
-
-
-
LPIDF
L
V
--
NQT
----
--
--
--
--
--
LT
L
G
T
EWNQQ
R
M
KDLSS
N
TQA
L
TGT
N
T
---
GGA
I
--
D
G
V
S
A
TD
------------------
R
S
P
Y
SK
AE
I
F
S
L
F
A
EN
N
ME
LTD
S
T
I
V
T
P
GLRFD
H
H
SIVGN
N
WS
PALNISQGL
GD
D
-
---F
T
LKM
G
I
A
RA
----------------
Y
KA
P
S
LY
Q
TN
P
N
--
-
YI
L
Y
S
----
-
K
G
Q
G
CY
A
--
S
AG
GCYLQGND
D
L
KAE
T
SIN
K
EIG
L
EFK
RD
G
-
-
W
L
AG
I
T
W
FR
N
D
YR
NKIE
A
G
Y
V
AV
G
QN
AV
GT
DLYQ
W
D
N
V
P
KA
V
VEG
L
E
G
S
LN---V
P
-
VSE
TVM
W
TN
N
I
T
Y
MLK
S
E
N
K
T
T
----
-
-
-----
GDRL
S
II
PEY
TLN
S
TLSW
QA
RE
D
L
S
M
Q
TTF
T
W
YG
KQQ
P
KKY
-
N
Y
KG
QPAVG
P
ETKEIS
P
-
Y
SIV
G
L
S
AT
W
D
VTKN
V
S
LTGG
VDNLFD
K
R
L
WRAGNA
Q
T
T
G
DLA
GANY
I
A
GA
G
AYT
Y
N
-
E
PG
--
RT
WY
M
SV
NTHF
fig|562.374.peg.5408
Escherichia coli 536A
MNKKIHSL
A
LLVNL
G
IYGVA
--
-
Q
A
Q
EP
TD
TPVSH
DDT
I
VVTA
-
A
E
Q
N
L
-
Q
AP
GV
S
---
-------------
T
I
T
A
DEIR
K
N
P
V
A
R
DVS
E
II
R
T
MPGVN
L
---
--
TGNST
S
G
Q
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
K
P
VS
S
R
NSV
RQGW
RGE
RDT
RG
DTSWVPPEM
I
E
R
I
EVLRGP
A
AA
R
YG
N
G
A
A
GG
V
V
NIITK
KG
SGEWH
G
SW
D
A
Y
F
NA
PE
H
KEEGATK
R
TN
FSLTGP
L
-
GD
EFSF
RLYG
NLD
--
KT
Q
A
D
AWD
IN
Q
--
G
HQSAR
AGTYATTLP
AGR
EG
V
I
N
K
DINGV
VR
WDF
AP
LQ
S
LELEA
G
YSRQGN
L
-
Y
AGD
TQ
NTNS
D
---------------
AY
T
RS
--
KY
G
D
-
E
T
NRL
Y
RQ
NY
S
LTWN
GG
WD
N
G
V
T
T
S
NWVQY
EH
-----------
TR
N
SR
IP
E
-
----
G
LA
G
-----
G
TEGKFNEK
A
TQDFVDN
D
L
D
D
V
M
L
H
SEV
N
-
-
-
LPIDF
L
V
--
NQT
----
--
--
--
--
--
LT
L
G
T
EWNQQ
R
M
KDLSS
N
TQA
L
TGT
N
T
---
GGA
I
--
D
G
V
S
A
TD
------------------
R
S
P
Y
SK
AE
I
F
S
L
F
A
EN
N
ME
LTD
S
T
I
V
T
P
GLRFD
H
H
SIVGN
N
WS
PALNISQGL
GD
D
-
---F
T
LKM
G
I
A
RA
----------------
Y
KA
P
S
LY
Q
TN
P
N
--
-
YI
L
Y
S
----
-
K
G
Q
G
CY
A
--
S
AG
GCYLQGND
D
L
KAE
T
SIN
K
EIG
L
EFK
RD
G
-
-
W
L
AG
I
T
W
FR
N
D
YR
NKIE
A
G
Y
V
AV
G
QN
AV
GT
DLYQ
W
D
N
V
P
KA
V
VEG
L
E
G
S
LN---V
P
-
VSE
TVM
W
TN
N
I
T
Y
MLK
S
E
N
K
T
T
----
-
-
-----
GDRL
S
II
PEY
TLN
S
TLSW
QA
RE
D
L
S
M
Q
TTF
T
W
YG
KQQ
P
KKY
-
N
Y
KG
QPAVG
P
ETKEIS
P
-
Y
SIV
G
L
S
AT
W
D
VTKN
V
S
LTGG
VDNLFD
K
R
L
WRAGNA
Q
T
T
G
DLA
GANY
I
A
GA
G
AYT
Y
N
-
E
PG
--
RT
WY
M
SV
NTHF
fig|83334.1.peg.696
Escherichia coli O157:H7
MNKKIHSL
A
LLVNL
G
IYGVA
--
-
Q
A
Q
EP
TD
TPVSH
DDT
I
VVTA
-
A
E
Q
N
L
-
Q
AP
GV
S
---
-------------
T
I
T
A
DEIR
K
N
P
V
A
R
DVS
E
II
R
T
MPGVN
L
---
--
TGNST
S
G
Q
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
K
P
VS
S
R
NSV
RQGW
RGE
RDT
RG
DTSWVPPEM
I
E
R
I
EVLRGP
A
AA
R
YG
N
G
A
A
GG
V
V
NIITK
KG
SGEWH
G
SW
D
A
Y
F
NA
PE
H
KEEGATK
R
TN
FSLTGP
L
-
GD
EFSF
RLYG
NLD
--
KT
Q
A
D
AWD
IN
Q
--
G
HQSAR
AGTYATTLP
AGR
EG
V
I
N
K
DINGV
VR
WDF
AP
LQ
S
LELEA
G
YSRQGN
L
-
Y
AGD
TQ
NTNS
D
---------------
AY
T
RS
--
KY
G
D
-
E
T
NRL
Y
RQ
NY
S
LTWN
GG
WD
N
G
V
T
T
S
NWVQY
EH
-----------
TR
N
SR
IP
E
-
----
G
LA
G
-----
G
TEGKFNEK
A
TQDFVDN
D
L
D
D
V
M
L
H
SEV
N
-
-
-
LPIDF
L
V
--
NQT
----
--
--
--
--
--
LT
L
G
T
EWNQQ
R
M
KDLSS
N
TQA
L
TGT
N
T
---
GGA
I
--
D
G
V
S
A
TD
------------------
R
S
P
Y
SK
AE
I
F
S
L
F
A
EN
N
ME
LTD
S
T
I
V
T
P
GLRFD
H
H
SIVGN
N
WS
PALNISQGL
GD
D
-
---F
T
LKM
G
I
A
RA
----------------
Y
KA
P
S
LY
Q
TN
P
N
--
-
YI
L
Y
S
----
-
K
G
Q
G
CY
A
--
S
AG
GCYLQGND
D
L
KAE
T
SIN
K
EIG
L
EFK
RD
G
-
-
W
L
AG
I
T
W
FR
N
D
YR
NKIE
A
G
Y
V
AV
G
QN
AV
GT
DLYQ
W
D
N
V
P
KA
V
VEG
L
E
G
S
LN---V
P
-
VSE
TVM
W
TN
N
I
T
Y
MLK
S
E
N
K
T
T
----
-
-
-----
GDRL
S
II
PEY
TLN
S
TLSW
QA
RE
D
L
S
M
Q
TTF
T
W
YG
KQQ
P
KKY
-
N
Y
KG
QPAVG
P
ETKEIS
P
-
Y
SIV
G
L
S
AT
W
D
VTKN
V
S
LTGG
VDNLFD
K
R
L
WRAGNA
Q
T
T
G
DLA
GANY
I
A
GA
G
AYT
Y
N
-
E
PG
--
RT
WY
M
SV
NTHF
fig|155864.1.peg.618
Escherichia coli O157:H7 EDL933
MNKKIHSL
A
LLVNL
G
IYGVA
--
-
Q
A
Q
EP
TD
TPVSH
DDT
I
VVTA
-
A
E
Q
N
L
-
Q
AP
GV
S
---
-------------
T
I
T
A
DEIR
K
N
P
V
A
R
DVS
E
II
R
T
MPGVN
L
---
--
TGNST
S
G
Q
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
K
P
VS
S
R
NSV
RQGW
RGE
RDT
RG
DTSWVPPEM
I
E
R
I
EVLRGP
A
AA
R
YG
N
G
A
A
GG
V
V
NIITK
KG
SGEWH
G
SW
D
A
Y
F
NA
PE
H
KEEGATK
R
TN
FSLTGP
L
-
GD
EFSF
RLYG
NLD
--
KT
Q
A
D
AWD
IN
Q
--
G
HQSAR
AGTYATTLP
AGR
EG
V
I
N
K
DINGV
VR
WDF
AP
LQ
S
LELEA
G
YSRQGN
L
-
Y
AGD
TQ
NTNS
D
---------------
AY
T
RS
--
KY
G
D
-
E
T
NRL
Y
RQ
NY
S
LTWN
GG
WD
N
G
V
T
T
S
NWVQY
EH
-----------
TR
N
SR
IP
E
-
----
G
LA
G
-----
G
TEGKFNEK
A
TQDFVDN
D
L
D
D
V
M
L
H
SEV
N
-
-
-
LPIDF
L
V
--
NQT
----
--
--
--
--
--
LT
L
G
T
EWNQQ
R
M
KDLSS
N
TQA
L
TGT
N
T
---
GGA
I
--
D
G
V
S
A
TD
------------------
R
S
P
Y
SK
AE
I
F
S
L
F
A
EN
N
ME
LTD
S
T
I
V
T
P
GLRFD
H
H
SIVGN
N
WS
PALNISQGL
GD
D
-
---F
T
LKM
G
I
A
RA
----------------
Y
KA
P
S
LY
Q
TN
P
N
--
-
YI
L
Y
S
----
-
K
G
Q
G
CY
A
--
S
AG
GCYLQGND
D
L
KAE
T
SIN
K
EIG
L
EFK
RD
G
-
-
W
L
AG
I
T
W
FR
N
D
YR
NKIE
A
G
Y
V
AV
G
QN
AV
GT
DLYQ
W
D
N
V
P
KA
V
VEG
L
E
G
S
LN---V
P
-
VSE
TVM
W
TN
N
I
T
Y
MLK
S
E
N
K
T
T
----
-
-
-----
GDRL
S
II
PEY
TLN
S
TLSW
QA
RE
D
L
S
M
Q
TTF
T
W
YG
KQQ
P
KKY
-
N
Y
KG
QPAVG
P
ETKEIS
P
-
Y
SIV
G
L
S
AT
W
D
VTKN
V
S
LTGG
VDNLFD
K
R
L
WRAGNA
Q
T
T
G
DLA
GANY
I
A
GA
G
AYT
Y
N
-
E
PG
--
RT
WY
M
SV
NTHF
fig|444454.5.peg.5108
Escherichia coli O157:H7 str. EC4024
MNKKIHSL
A
LLVNL
G
IYGVA
--
-
Q
A
Q
EP
TD
TPVSH
DDT
I
VVTA
-
A
E
Q
N
L
-
Q
AP
GV
S
---
-------------
T
I
T
A
DEIR
K
N
P
V
A
R
DVS
E
II
R
T
MPGVN
L
---
--
TGNST
S
G
Q
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
K
P
VS
S
R
NSV
RQGW
RGE
RDT
RG
DTSWVPPEM
I
E
R
I
EVLRGP
A
AA
R
YG
N
G
A
A
GG
V
V
NIITK
KG
SGEWH
G
SW
D
A
Y
F
NA
PE
H
KEEGATK
R
TN
FSLTGP
L
-
GD
EFSF
RLYG
NLD
--
KT
Q
A
D
AWD
IN
Q
--
G
HQSAR
AGTYATTLP
AGR
EG
V
I
N
K
DINGV
VR
WDF
AP
LQ
S
LELEA
G
YSRQGN
L
-
Y
AGD
TQ
NTNS
D
---------------
AY
T
RS
--
KY
G
D
-
E
T
NRL
Y
RQ
NY
S
LTWN
GG
WD
N
G
V
T
T
S
NWVQY
EH
-----------
TR
N
SR
IP
E
-
----
G
LA
G
-----
G
TEGKFNEK
A
TQDFVDN
D
L
D
D
V
M
L
H
SEV
N
-
-
-
LPIDF
L
V
--
NQT
----
--
--
--
--
--
LT
L
G
T
EWNQQ
R
M
KDLSS
N
TQA
L
TGT
N
T
---
GGA
I
--
D
G
V
S
A
TD
------------------
R
S
P
Y
SK
AE
I
F
S
L
F
A
EN
N
ME
LTD
S
T
I
V
T
P
GLRFD
H
H
SIVGN
N
WS
PALNISQGL
GD
D
-
---F
T
LKM
G
I
A
RA
----------------
Y
KA
P
S
LY
Q
TN
P
N
--
-
YI
L
Y
S
----
-
K
G
Q
G
CY
A
--
S
AG
GCYLQGND
D
L
KAE
T
SIN
K
EIG
L
EFK
RD
G
-
-
W
L
AG
I
T
W
FR
N
D
YR
NKIE
A
G
Y
V
AV
G
QN
AV
GT
DLYQ
W
D
N
V
P
KA
V
VEG
L
E
G
S
LN---V
P
-
VSE
TVM
W
TN
N
I
T
Y
MLK
S
E
N
K
T
T
----
-
-
-----
GDRL
S
II
PEY
TLN
S
TLSW
QA
RE
D
L
S
M
Q
TTF
T
W
YG
KQQ
P
KKY
-
N
Y
KG
QPAVG
P
ETKEIS
P
-
Y
SIV
G
L
S
AT
W
D
VTKN
V
S
LTGG
VDNLFD
K
R
L
WRAGNA
Q
T
T
G
DLA
GANY
I
A
GA
G
AYT
Y
N
-
E
PG
--
RT
WY
M
SV
NTHF
fig|444449.5.peg.5444
Escherichia coli O157:H7 str. EC4042
MNKKIHSL
A
LLVNL
G
IYGVA
--
-
Q
A
Q
EP
TD
TPVSH
DDT
I
VVTA
-
A
E
Q
N
L
-
Q
AP
GV
S
---
-------------
T
I
T
A
DEIR
K
N
P
V
A
R
DVS
E
II
R
T
MPGVN
L
---
--
TGNST
S
G
Q
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
K
P
VS
S
R
NSV
RQGW
RGE
RDT
RG
DTSWVPPEM
I
E
R
I
EVLRGP
A
AA
R
YG
N
G
A
A
GG
V
V
NIITK
KG
SGEWH
G
SW
D
A
Y
F
NA
PE
H
KEEGATK
R
TN
FSLTGP
L
-
GD
EFSF
RLYG
NLD
--
KT
Q
A
D
AWD
IN
Q
--
G
HQSAR
AGTYATTLP
AGR
EG
V
I
N
K
DINGV
VR
WDF
AP
LQ
S
LELEA
G
YSRQGN
L
-
Y
AGD
TQ
NTNS
D
---------------
AY
T
RS
--
KY
G
D
-
E
T
NRL
Y
RQ
NY
S
LTWN
GG
WD
N
G
V
T
T
S
NWVQY
EH
-----------
TR
N
SR
IP
E
-
----
G
LA
G
-----
G
TEGKFNEK
A
TQDFVDN
D
L
D
D
V
M
L
H
SEV
N
-
-
-
LPIDF
L
V
--
NQT
----
--
--
--
--
--
LT
L
G
T
EWNQQ
R
M
KDLSS
N
TQA
L
TGT
N
T
---
GGA
I
--
D
G
V
S
A
TD
------------------
R
S
P
Y
SK
AE
I
F
S
L
F
A
EN
N
ME
LTD
S
T
I
V
T
P
GLRFD
H
H
SIVGN
N
WS
PALNISQGL
GD
D
-
---F
T
LKM
G
I
A
RA
----------------
Y
KA
P
S
LY
Q
TN
P
N
--
-
YI
L
Y
S
----
-
K
G
Q
G
CY
A
--
S
AG
GCYLQGND
D
L
KAE
T
SIN
K
EIG
L
EFK
RD
G
-
-
W
L
AG
I
T
W
FR
N
D
YR
NKIE
A
G
Y
V
AV
G
QN
AV
GT
DLYQ
W
D
N
V
P
KA
V
VEG
L
E
G
S
LN---V
P
-
VSE
TVM
W
TN
N
I
T
Y
MLK
S
E
N
K
T
T
----
-
-
-----
GDRL
S
II
PEY
TLN
S
TLSW
QA
RE
D
L
S
M
Q
TTF
T
W
YG
KQQ
P
KKY
-
N
Y
KG
QPAVG
P
ETKEIS
P
-
Y
SIV
G
L
S
AT
W
D
VTKN
V
S
LTGG
VDNLFD
K
R
L
WRAGNA
Q
T
T
G
DLA
GANY
I
A
GA
G
AYT
Y
N
-
E
PG
--
RT
WY
M
SV
NTHF
fig|444448.5.peg.3318
Escherichia coli O157:H7 str. EC4045
MNKKIHSL
A
LLVNL
G
IYGVA
--
-
Q
A
Q
EP
TD
TPVSH
DDT
I
VVTA
-
A
E
Q
N
L
-
Q
AP
GV
S
---
-------------
T
I
T
A
DEIR
K
N
P
V
A
R
DVS
E
II
R
T
MPGVN
L
---
--
TGNST
S
G
Q
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
K
P
VS
S
R
NSV
RQGW
RGE
RDT
RG
DTSWVPPEM
I
E
R
I
EVLRGP
A
AA
R
YG
N
G
A
A
GG
V
V
NIITK
KG
SGEWH
G
SW
D
A
Y
F
NA
PE
H
KEEGATK
R
TN
FSLTGP
L
-
GD
EFSF
RLYG
NLD
--
KT
Q
A
D
AWD
IN
Q
--
G
HQSAR
AGTYATTLP
AGR
EG
V
I
N
K
DINGV
VR
WDF
AP
LQ
S
LELEA
G
YSRQGN
L
-
Y
AGD
TQ
NTNS
D
---------------
AY
T
RS
--
KY
G
D
-
E
T
NRL
Y
RQ
NY
S
LTWN
GG
WD
N
G
V
T
T
S
NWVQY
EH
-----------
TR
N
SR
IP
E
-
----
G
LA
G
-----
G
TEGKFNEK
A
TQDFVDN
D
L
D
D
V
M
L
H
SEV
N
-
-
-
LPIDF
L
V
--
NQT
----
--
--
--
--
--
LT
L
G
T
EWNQQ
R
M
KDLSS
N
TQA
L
TGT
N
T
---
GGA
I
--
D
G
V
S
A
TD
------------------
R
S
P
Y
SK
AE
I
F
S
L
F
A
EN
N
ME
LTD
S
T
I
V
T
P
GLRFD
H
H
SIVGN
N
WS
PALNISQGL
GD
D
-
---F
T
LKM
G
I
A
RA
----------------
Y
KA
P
S
LY
Q
TN
P
N
--
-
YI
L
Y
S
----
-
K
G
Q
G
CY
A
--
S
AG
GCYLQGND
D
L
KAE
T
SIN
K
EIG
L
EFK
RD
G
-
-
W
L
AG
I
T
W
FR
N
D
YR
NKIE
A
G
Y
V
AV
G
QN
AV
GT
DLYQ
W
D
N
V
P
KA
V
VEG
L
E
G
S
LN---V
P
-
VSE
TVM
W
TN
N
I
T
Y
MLK
S
E
N
K
T
T
----
-
-
-----
GDRL
S
II
PEY
TLN
S
TLSW
QA
RE
D
L
S
M
Q
TTF
T
W
YG
KQQ
P
KKY
-
N
Y
KG
QPAVG
P
ETKEIS
P
-
Y
SIV
G
L
S
AT
W
D
VTKN
V
S
LTGG
VDNLFD
K
R
L
WRAGNA
Q
T
T
G
DLA
GANY
I
A
GA
G
AYT
Y
N
-
E
PG
--
RT
WY
M
SV
NTHF
fig|444453.5.peg.660
Escherichia coli O157:H7 str. EC4076
MNKKIHSL
A
LLVNL
G
IYGVA
--
-
Q
A
Q
EP
TD
TPVSH
DDT
I
VVTA
-
A
E
Q
N
L
-
Q
AP
GV
S
---
-------------
T
I
T
A
DEIR
K
N
P
V
A
R
DVS
E
II
R
T
MPGVN
L
---
--
TGNST
S
G
Q
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
K
P
VS
S
R
NSV
RQGW
RGE
RDT
RG
DTSWVPPEM
I
E
R
I
EVLRGP
A
AA
R
YG
N
G
A
A
GG
V
V
NIITK
KG
SGEWH
G
SW
D
A
Y
F
NA
PE
H
KEEGATK
R
TN
FSLTGP
L
-
GD
EFSF
RLYG
NLD
--
KT
Q
A
D
AWD
IN
Q
--
G
HQSAR
AGTYATTLP
AGR
EG
V
I
N
K
DINGV
VR
WDF
AP
LQ
S
LELEA
G
YSRQGN
L
-
Y
AGD
TQ
NTNS
D
---------------
AY
T
RS
--
KY
G
D
-
E
T
NRL
Y
RQ
NY
S
LTWN
GG
WD
N
G
V
T
T
S
NWVQY
EH
-----------
TR
N
SR
IP
E
-
----
G
LA
G
-----
G
TEGKFNEK
A
TQDFVDN
D
L
D
D
V
M
L
H
SEV
N
-
-
-
LPIDF
L
V
--
NQT
----
--
--
--
--
--
LT
L
G
T
EWNQQ
R
M
KDLSS
N
TQA
L
TGT
N
T
---
GGA
I
--
D
G
V
S
A
TD
------------------
R
S
P
Y
SK
AE
I
F
S
L
F
A
EN
N
ME
LTD
S
T
I
V
T
P
GLRFD
H
H
SIVGN
N
WS
PALNISQGL
GD
D
-
---F
T
LKM
G
I
A
RA
----------------
Y
KA
P
S
LY
Q
TN
P
N
--
-
YI
L
Y
S
----
-
K
G
Q
G
CY
A
--
S
AG
GCYLQGND
D
L
KAE
T
SIN
K
EIG
L
EFK
RD
G
-
-
W
L
AG
I
T
W
FR
N
D
YR
NKIE
A
G
Y
V
AV
G
QN
AV
GT
DLYQ
W
D
N
V
P
KA
V
VEG
L
E
G
S
LN---V
P
-
VSE
TVM
W
TN
N
I
T
Y
MLK
S
E
N
K
T
T
----
-
-
-----
GDRL
S
II
PEY
TLN
S
TLSW
QA
RE
D
L
S
M
Q
TTF
T
W
YG
KQQ
P
KKY
-
N
Y
KG
QPAVG
P
ETKEIS
P
-
Y
SIV
G
L
S
AT
W
D
VTKN
V
S
LTGG
VDNLFD
K
R
L
WRAGNA
Q
T
T
G
DLA
GANY
I
A
GA
G
AYT
Y
N
-
E
PG
--
RT
WY
M
SV
NTHF
fig|444452.5.peg.868
Escherichia coli O157:H7 str. EC4113
MNKKIHSL
A
LLVNL
G
IYGVA
--
-
Q
A
Q
EP
TD
TPVSH
DDT
I
VVTA
-
A
E
Q
N
L
-
Q
AP
GV
S
---
-------------
T
I
T
A
DEIR
K
N
P
V
A
R
DVS
E
II
R
T
MPGVN
L
---
--
TGNST
S
G
Q
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
K
P
VS
S
R
NSV
RQGW
RGE
RDT
RG
DTSWVPPEM
I
E
R
I
EVLRGP
A
AA
R
YG
N
G
A
A
GG
V
V
NIITK
KG
SGEWH
G
SW
D
A
Y
F
NA
PE
H
KEEGATK
R
TN
FSLTGP
L
-
GD
EFSF
RLYG
NLD
--
KT
Q
A
D
AWD
IN
Q
--
G
HQSAR
AGTYATTLP
AGR
EG
V
I
N
K
DINGV
VR
WDF
AP
LQ
S
LELEA
G
YSRQGN
L
-
Y
AGD
TQ
NTNS
D
---------------
AY
T
RS
--
KY
G
D
-
E
T
NRL
Y
RQ
NY
S
LTWN
GG
WD
N
G
V
T
T
S
NWVQY
EH
-----------
TR
N
SR
IP
E
-
----
G
LA
G
-----
G
TEGKFNEK
A
TQDFVDN
D
L
D
D
V
M
L
H
SEV
N
-
-
-
LPIDF
L
V
--
NQT
----
--
--
--
--
--
LT
L
G
T
EWNQQ
R
M
KDLSS
N
TQA
L
TGT
N
T
---
GGA
I
--
D
G
V
S
A
TD
------------------
R
S
P
Y
SK
AE
I
F
S
L
F
A
EN
N
ME
LTD
S
T
I
V
T
P
GLRFD
H
H
SIVGN
N
WS
PALNISQGL
GD
D
-
---F
T
LKM
G
I
A
RA
----------------
Y
KA
P
S
LY
Q
TN
P
N
--
-
YI
L
Y
S
----
-
K
G
Q
G
CY
A
--
S
AG
GCYLQGND
D
L
KAE
T
SIN
K
EIG
L
EFK
RD
G
-
-
W
L
AG
I
T
W
FR
N
D
YR
NKIE
A
G
Y
V
AV
G
QN
AV
GT
DLYQ
W
D
N
V
P
KA
V
VEG
L
E
G
S
LN---V
P
-
VSE
TVM
W
TN
N
I
T
Y
MLK
S
E
N
K
T
T
----
-
-
-----
GDRL
S
II
PEY
TLN
S
TLSW
QA
RE
D
L
S
M
Q
TTF
T
W
YG
KQQ
P
KKY
-
N
Y
KG
QPAVG
P
ETKEIS
P
-
Y
SIV
G
L
S
AT
W
D
VTKN
V
S
LTGG
VDNLFD
K
R
L
WRAGNA
Q
T
T
G
DLA
GANY
I
A
GA
G
AYT
Y
N
-
E
PG
--
RT
WY
M
SV
NTHF
fig|444450.8.peg.778
Escherichia coli O157:H7 str. EC4115
MNKKIHSL
A
LLVNL
G
IYGVA
--
-
Q
A
Q
EP
TD
TPVSH
DDT
I
VVTA
-
A
E
Q
N
L
-
Q
AP
GV
S
---
-------------
T
I
T
A
DEIR
K
N
P
V
A
R
DVS
E
II
R
T
MPGVN
L
---
--
TGNST
S
G
Q
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
K
P
VS
S
R
NSV
RQGW
RGE
RDT
RG
DTSWVPPEM
I
E
R
I
EVLRGP
A
AA
R
YG
N
G
A
A
GG
V
V
NIITK
KG
SGEWH
G
SW
D
A
Y
F
NA
PE
H
KEEGATK
R
TN
FSLTGP
L
-
GD
EFSF
RLYG
NLD
--
KT
Q
A
D
AWD
IN
Q
--
G
HQSAR
AGTYATTLP
AGR
EG
V
I
N
K
DINGV
VR
WDF
AP
LQ
S
LELEA
G
YSRQGN
L
-
Y
AGD
TQ
NTNS
D
---------------
AY
T
RS
--
KY
G
D
-
E
T
NRL
Y
RQ
NY
S
LTWN
GG
WD
N
G
V
T
T
S
NWVQY
EH
-----------
TR
N
SR
IP
E
-
----
G
LA
G
-----
G
TEGKFNEK
A
TQDFVDN
D
L
D
D
V
M
L
H
SEV
N
-
-
-
LPIDF
L
V
--
NQT
----
--
--
--
--
--
LT
L
G
T
EWNQQ
R
M
KDLSS
N
TQA
L
TGT
N
T
---
GGA
I
--
D
G
V
S
A
TD
------------------
R
S
P
Y
SK
AE
I
F
S
L
F
A
EN
N
ME
LTD
S
T
I
V
T
P
GLRFD
H
H
SIVGN
N
WS
PALNISQGL
GD
D
-
---F
T
LKM
G
I
A
RA
----------------
Y
KA
P
S
LY
Q
TN
P
N
--
-
YI
L
Y
S
----
-
K
G
Q
G
CY
A
--
S
AG
GCYLQGND
D
L
KAE
T
SIN
K
EIG
L
EFK
RD
G
-
-
W
L
AG
I
T
W
FR
N
D
YR
NKIE
A
G
Y
V
AV
G
QN
AV
GT
DLYQ
W
D
N
V
P
KA
V
VEG
L
E
G
S
LN---V
P
-
VSE
TVM
W
TN
N
I
T
Y
MLK
S
E
N
K
T
T
----
-
-
-----
GDRL
S
II
PEY
TLN
S
TLSW
QA
RE
D
L
S
M
Q
TTF
T
W
YG
KQQ
P
KKY
-
N
Y
KG
QPAVG
P
ETKEIS
P
-
Y
SIV
G
L
S
AT
W
D
VTKN
V
S
LTGG
VDNLFD
K
R
L
WRAGNA
Q
T
T
G
DLA
GANY
I
A
GA
G
AYT
Y
N
-
E
PG
--
RT
WY
M
SV
NTHF
fig|444451.5.peg.2280
Escherichia coli O157:H7 str. EC4196
MNKKIHSL
A
LLVNL
G
IYGVA
--
-
Q
A
Q
EP
TD
TPVSH
DDT
I
VVTA
-
A
E
Q
N
L
-
Q
AP
GV
S
---
-------------
T
I
T
A
DEIR
K
N
P
V
A
R
DVS
E
II
R
T
MPGVN
L
---
--
TGNST
S
G
Q
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
K
P
VS
S
R
NSV
RQGW
RGE
RDT
RG
DTSWVPPEM
I
E
R
I
EVLRGP
A
AA
R
YG
N
G
A
A
GG
V
V
NIITK
KG
SGEWH
G
SW
D
A
Y
F
NA
PE
H
KEEGATK
R
TN
FSLTGP
L
-
GD
EFSF
RLYG
NLD
--
KT
Q
A
D
AWD
IN
Q
--
G
HQSAR
AGTYATTLP
AGR
EG
V
I
N
K
DINGV
VR
WDF
AP
LQ
S
LELEA
G
YSRQGN
L
-
Y
AGD
TQ
NTNS
D
---------------
AY
T
RS
--
KY
G
D
-
E
T
NRL
Y
RQ
NY
S
LTWN
GG
WD
N
G
V
T
T
S
NWVQY
EH
-----------
TR
N
SR
IP
E
-
----
G
LA
G
-----
G
TEGKFNEK
A
TQDFVDN
D
L
D
D
V
M
L
H
SEV
N
-
-
-
LPIDF
L
V
--
NQT
----
--
--
--
--
--
LT
L
G
T
EWNQQ
R
M
KDLSS
N
TQA
L
TGT
N
T
---
GGA
I
--
D
G
V
S
A
TD
------------------
R
S
P
Y
SK
AE
I
F
S
L
F
A
EN
N
ME
LTD
S
T
I
V
T
P
GLRFD
H
H
SIVGN
N
WS
PALNISQGL
GD
D
-
---F
T
LKM
G
I
A
RA
----------------
Y
KA
P
S
LY
Q
TN
P
N
--
-
YI
L
Y
S
----
-
K
G
Q
G
CY
A
--
S
AG
GCYLQGND
D
L
KAE
T
SIN
K
EIG
L
EFK
RD
G
-
-
W
L
AG
I
T
W
FR
N
D
YR
NKIE
A
G
Y
V
AV
G
QN
AV
GT
DLYQ
W
D
N
V
P
KA
V
VEG
L
E
G
S
LN---V
P
-
VSE
TVM
W
TN
N
I
T
Y
MLK
S
E
N
K
T
T
----
-
-
-----
GDRL
S
II
PEY
TLN
S
TLSW
QA
RE
D
L
S
M
Q
TTF
T
W
YG
KQQ
P
KKY
-
N
Y
KG
QPAVG
P
ETKEIS
P
-
Y
SIV
G
L
S
AT
W
D
VTKN
V
S
LTGG
VDNLFD
K
R
L
WRAGNA
Q
T
T
G
DLA
GANY
I
A
GA
G
AYT
Y
N
-
E
PG
--
RT
WY
M
SV
NTHF
fig|444447.5.peg.3493
Escherichia coli O157:H7 str. EC4206
MNKKIHSL
A
LLVNL
G
IYGVA
--
-
Q
A
Q
EP
TD
TPVSH
DDT
I
VVTA
-
A
E
Q
N
L
-
Q
AP
GV
S
---
-------------
T
I
T
A
DEIR
K
N
P
V
A
R
DVS
E
II
R
T
MPGVN
L
---
--
TGNST
S
G
Q
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
K
P
VS
S
R
NSV
RQGW
RGE
RDT
RG
DTSWVPPEM
I
E
R
I
EVLRGP
A
AA
R
YG
N
G
A
A
GG
V
V
NIITK
KG
SGEWH
G
SW
D
A
Y
F
NA
PE
H
KEEGATK
R
TN
FSLTGP
L
-
GD
EFSF
RLYG
NLD
--
KT
Q
A
D
AWD
IN
Q
--
G
HQSAR
AGTYATTLP
AGR
EG
V
I
N
K
DINGV
VR
WDF
AP
LQ
S
LELEA
G
YSRQGN
L
-
Y
AGD
TQ
NTNS
D
---------------
AY
T
RS
--
KY
G
D
-
E
T
NRL
Y
RQ
NY
S
LTWN
GG
WD
N
G
V
T
T
S
NWVQY
EH
-----------
TR
N
SR
IP
E
-
----
G
LA
G
-----
G
TEGKFNEK
A
TQDFVDN
D
L
D
D
V
M
L
H
SEV
N
-
-
-
LPIDF
L
V
--
NQT
----
--
--
--
--
--
LT
L
G
T
EWNQQ
R
M
KDLSS
N
TQA
L
TGT
N
T
---
GGA
I
--
D
G
V
S
A
TD
------------------
R
S
P
Y
SK
AE
I
F
S
L
F
A
EN
N
ME
LTD
S
T
I
V
T
P
GLRFD
H
H
SIVGN
N
WS
PALNISQGL
GD
D
-
---F
T
LKM
G
I
A
RA
----------------
Y
KA
P
S
LY
Q
TN
P
N
--
-
YI
L
Y
S
----
-
K
G
Q
G
CY
A
--
S
AG
GCYLQGND
D
L
KAE
T
SIN
K
EIG
L
EFK
RD
G
-
-
W
L
AG
I
T
W
FR
N
D
YR
NKIE
A
G
Y
V
AV
G
QN
AV
GT
DLYQ
W
D
N
V
P
KA
V
VEG
L
E
G
S
LN---V
P
-
VSE
TVM
W
TN
N
I
T
Y
MLK
S
E
N
K
T
T
----
-
-
-----
GDRL
S
II
PEY
TLN
S
TLSW
QA
RE
D
L
S
M
Q
TTF
T
W
YG
KQQ
P
KKY
-
N
Y
KG
QPAVG
P
ETKEIS
P
-
Y
SIV
G
L
S
AT
W
D
VTKN
V
S
LTGG
VDNLFD
K
R
L
WRAGNA
Q
T
T
G
DLA
GANY
I
A
GA
G
AYT
Y
N
-
E
PG
--
RT
WY
M
SV
NTHF
fig|478004.5.peg.1486
Escherichia coli O157:H7 str. EC4401
MNKKIHSL
A
LLVNL
G
IYGVA
--
-
Q
A
Q
EP
TD
TPVSH
DDT
I
VVTA
-
A
E
Q
N
L
-
Q
AP
GV
S
---
-------------
T
I
T
A
DEIR
K
N
P
V
A
R
DVS
E
II
R
T
MPGVN
L
---
--
TGNST
S
G
Q
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
K
P
VS
S
R
NSV
RQGW
RGE
RDT
RG
DTSWVPPEM
I
E
R
I
EVLRGP
A
AA
R
YG
N
G
A
A
GG
V
V
NIITK
KG
SGEWH
G
SW
D
A
Y
F
NA
PE
H
KEEGATK
R
TN
FSLTGP
L
-
GD
EFSF
RLYG
NLD
--
KT
Q
A
D
AWD
IN
Q
--
G
HQSAR
AGTYATTLP
AGR
EG
V
I
N
K
DINGV
VR
WDF
AP
LQ
S
LELEA
G
YSRQGN
L
-
Y
AGD
TQ
NTNS
D
---------------
AY
T
RS
--
KY
G
D
-
E
T
NRL
Y
RQ
NY
S
LTWN
GG
WD
N
G
V
T
T
S
NWVQY
EH
-----------
TR
N
SR
IP
E
-
----
G
LA
G
-----
G
TEGKFNEK
A
TQDFVDN
D
L
D
D
V
M
L
H
SEV
N
-
-
-
LPIDF
L
V
--
NQT
----
--
--
--
--
--
LT
L
G
T
EWNQQ
R
M
KDLSS
N
TQA
L
TGT
N
T
---
GGA
I
--
D
G
V
S
A
TD
------------------
R
S
P
Y
SK
AE
I
F
S
L
F
A
EN
N
ME
LTD
S
T
I
V
T
P
GLRFD
H
H
SIVGN
N
WS
PALNISQGL
GD
D
-
---F
T
LKM
G
I
A
RA
----------------
Y
KA
P
S
LY
Q
TN
P
N
--
-
YI
L
Y
S
----
-
K
G
Q
G
CY
A
--
S
AG
GCYLQGND
D
L
KAE
T
SIN
K
EIG
L
EFK
RD
G
-
-
W
L
AG
I
T
W
FR
N
D
YR
NKIE
A
G
Y
V
AV
G
QN
AV
GT
DLYQ
W
D
N
V
P
KA
V
VEG
L
E
G
S
LN---V
P
-
VSE
TVM
W
TN
N
I
T
Y
MLK
S
E
N
K
T
T
----
-
-
-----
GDRL
S
II
PEY
TLN
S
TLSW
QA
RE
D
L
S
M
Q
TTF
T
W
YG
KQQ
P
KKY
-
N
Y
KG
QPAVG
P
ETKEIS
P
-
Y
SIV
G
L
S
AT
W
D
VTKN
V
S
LTGG
VDNLFD
K
R
L
WRAGNA
Q
T
T
G
DLA
GANY
I
A
GA
G
AYT
Y
N
-
E
PG
--
RT
WY
M
SV
NTHF
fig|478005.5.peg.3996
Escherichia coli O157:H7 str. EC4486
MNKKIHSL
A
LLVNL
G
IYGVA
--
-
Q
A
Q
EP
TD
TPVSH
DDT
I
VVTA
-
A
E
Q
N
L
-
Q
AP
GV
S
---
-------------
T
I
T
A
DEIR
K
N
P
V
A
R
DVS
E
II
R
T
MPGVN
L
---
--
TGNST
S
G
Q
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
K
P
VS
S
R
NSV
RQGW
RGE
RDT
RG
DTSWVPPEM
I
E
R
I
EVLRGP
A
AA
R
YG
N
G
A
A
GG
V
V
NIITK
KG
SGEWH
G
SW
D
A
Y
F
NA
PE
H
KEEGATK
R
TN
FSLTGP
L
-
GD
EFSF
RLYG
NLD
--
KT
Q
A
D
AWD
IN
Q
--
G
HQSAR
AGTYATTLP
AGR
EG
V
I
N
K
DINGV
VR
WDF
AP
LQ
S
LELEA
G
YSRQGN
L
-
Y
AGD
TQ
NTNS
D
---------------
AY
T
RS
--
KY
G
D
-
E
T
NRL
Y
RQ
NY
S
LTWN
GG
WD
N
G
V
T
T
S
NWVQY
EH
-----------
TR
N
SR
IP
E
-
----
G
LA
G
-----
G
TEGKFNEK
A
TQDFVDN
D
L
D
D
V
M
L
H
SEV
N
-
-
-
LPIDF
L
V
--
NQT
----
--
--
--
--
--
LT
L
G
T
EWNQQ
R
M
KDLSS
N
TQA
L
TGT
N
T
---
GGA
I
--
D
G
V
S
A
TD
------------------
R
S
P
Y
SK
AE
I
F
S
L
F
A
EN
N
ME
LTD
S
T
I
V
T
P
GLRFD
H
H
SIVGN
N
WS
PALNISQGL
GD
D
-
---F
T
LKM
G
I
A
RA
----------------
Y
KA
P
S
LY
Q
TN
P
N
--
-
YI
L
Y
S
----
-
K
G
Q
G
CY
A
--
S
AG
GCYLQGND
D
L
KAE
T
SIN
K
EIG
L
EFK
RD
G
-
-
W
L
AG
I
T
W
FR
N
D
YR
NKIE
A
G
Y
V
AV
G
QN
AV
GT
DLYQ
W
D
N
V
P
KA
V
VEG
L
E
G
S
LN---V
P
-
VSE
TVM
W
TN
N
I
T
Y
MLK
S
E
N
K
T
T
----
-
-
-----
GDRL
S
II
PEY
TLN
S
TLSW
QA
RE
D
L
S
M
Q
TTF
T
W
YG
KQQ
P
KKY
-
N
Y
KG
QPAVG
P
ETKEIS
P
-
Y
SIV
G
L
S
AT
W
D
VTKN
V
S
LTGG
VDNLFD
K
R
L
WRAGNA
Q
T
T
G
DLA
GANY
I
A
GA
G
AYT
Y
N
-
E
PG
--
RT
WY
M
SV
NTHF
fig|478006.5.peg.825
Escherichia coli O157:H7 str. EC4501
MNKKIHSL
A
LLVNL
G
IYGVA
--
-
Q
A
Q
EP
TD
TPVSH
DDT
I
VVTA
-
A
E
Q
N
L
-
Q
AP
GV
S
---
-------------
T
I
T
A
DEIR
K
N
P
V
A
R
DVS
E
II
R
T
MPGVN
L
---
--
TGNST
S
G
Q
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
K
P
VS
S
R
NSV
RQGW
RGE
RDT
RG
DTSWVPPEM
I
E
R
I
EVLRGP
A
AA
R
YG
N
G
A
A
GG
V
V
NIITK
KG
SGEWH
G
SW
D
A
Y
F
NA
PE
H
KEEGATK
R
TN
FSLTGP
L
-
GD
EFSF
RLYG
NLD
--
KT
Q
A
D
AWD
IN
Q
--
G
HQSAR
AGTYATTLP
AGR
EG
V
I
N
K
DINGV
VR
WDF
AP
LQ
S
LELEA
G
YSRQGN
L
-
Y
AGD
TQ
NTNS
D
---------------
AY
T
RS
--
KY
G
D
-
E
T
NRL
Y
RQ
NY
S
LTWN
GG
WD
N
G
V
T
T
S
NWVQY
EH
-----------
TR
N
SR
IP
E
-
----
G
LA
G
-----
G
TEGKFNEK
A
TQDFVDN
D
L
D
D
V
M
L
H
SEV
N
-
-
-
LPIDF
L
V
--
NQT
----
--
--
--
--
--
LT
L
G
T
EWNQQ
R
M
KDLSS
N
TQA
L
TGT
N
T
---
GGA
I
--
D
G
V
S
A
TD
------------------
R
S
P
Y
SK
AE
I
F
S
L
F
A
EN
N
ME
LTD
S
T
I
V
T
P
GLRFD
H
H
SIVGN
N
WS
PALNISQGL
GD
D
-
---F
T
LKM
G
I
A
RA
----------------
Y
KA
P
S
LY
Q
TN
P
N
--
-
YI
L
Y
S
----
-
K
G
Q
G
CY
A
--
S
AG
GCYLQGND
D
L
KAE
T
SIN
K
EIG
L
EFK
RD
G
-
-
W
L
AG
I
T
W
FR
N
D
YR
NKIE
A
G
Y
V
AV
G
QN
AV
GT
DLYQ
W
D
N
V
P
KA
V
VEG
L
E
G
S
LN---V
P
-
VSE
TVM
W
TN
N
I
T
Y
MLK
S
E
N
K
T
T
----
-
-
-----
GDRL
S
II
PEY
TLN
S
TLSW
QA
RE
D
L
S
M
Q
TTF
T
W
YG
KQQ
P
KKY
-
N
Y
KG
QPAVG
P
ETKEIS
P
-
Y
SIV
G
L
S
AT
W
D
VTKN
V
S
LTGG
VDNLFD
K
R
L
WRAGNA
Q
T
T
G
DLA
GANY
I
A
GA
G
AYT
Y
N
-
E
PG
--
RT
WY
M
SV
NTHF
fig|478007.5.peg.977
Escherichia coli O157:H7 str. EC508
MNKKIHSL
A
LLVNL
G
IYGVA
--
-
Q
A
Q
EP
TD
TPVSH
DDT
I
VVTA
-
A
E
Q
N
L
-
Q
AP
GV
S
---
-------------
T
I
T
A
DEIR
K
N
P
V
A
R
DVS
E
II
R
T
MPGVN
L
---
--
TGNST
S
G
Q
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
K
P
VS
S
R
NSV
RQGW
RGE
RDT
RG
DTSWVPPEM
I
E
R
I
EVLRGP
A
AA
R
YG
N
G
A
A
GG
V
V
NIITK
KG
SGEWH
G
SW
D
A
Y
F
NA
PE
H
KEEGATK
R
TN
FSLTGP
L
-
GD
EFSF
RLYG
NLD
--
KT
Q
A
D
AWD
IN
Q
--
G
HQSAR
AGTYATTLP
AGR
EG
V
I
N
K
DINGV
VR
WDF
AP
LQ
S
LELEA
G
YSRQGN
L
-
Y
AGD
TQ
NTNS
D
---------------
AY
T
RS
--
KY
G
D
-
E
T
NRL
Y
RQ
NY
S
LTWN
GG
WD
N
G
V
T
T
S
NWVQY
EH
-----------
TR
N
SR
IP
E
-
----
G
LA
G
-----
G
TEGKFNEK
A
TQDFVDN
D
L
D
D
V
M
L
H
SEV
N
-
-
-
LPIDF
L
V
--
NQT
----
--
--
--
--
--
LT
L
G
T
EWNQQ
R
M
KDLSS
N
TQA
L
TGT
N
T
---
GGA
I
--
D
G
V
S
A
TD
------------------
R
S
P
Y
SK
AE
I
F
S
L
F
A
EN
N
ME
LTD
S
T
I
V
T
P
GLRFD
H
H
SIVGN
N
WS
PALNISQGL
GD
D
-
---F
T
LKM
G
I
A
RA
----------------
Y
KA
P
S
LY
Q
TN
P
N
--
-
YI
L
Y
S
----
-
K
G
Q
G
CY
A
--
S
AG
GCYLQGND
D
L
KAE
T
SIN
K
EIG
L
EFK
RD
G
-
-
W
L
AG
I
T
W
FR
N
D
YR
NKIE
A
G
Y
V
AV
G
QN
AV
GT
DLYQ
W
D
N
V
P
KA
V
VEG
L
E
G
S
LN---V
P
-
VSE
TVM
W
TN
N
I
T
Y
MLK
S
E
N
K
T
T
----
-
-
-----
GDRL
S
II
PEY
TLN
S
TLSW
QA
RE
D
L
S
M
Q
TTF
T
W
YG
KQQ
P
KKY
-
N
Y
KG
QPAVG
P
ETKEIS
P
-
Y
SIV
G
L
S
AT
W
D
VTKN
V
S
LTGG
VDNLFD
K
R
L
WRAGNA
Q
T
T
G
DLA
GANY
I
A
GA
G
AYT
Y
N
-
E
PG
--
RT
WY
M
SV
NTHF
fig|478008.5.peg.1720
Escherichia coli O157:H7 str. EC869
MNKKIHSL
A
LLVNL
G
IYGVA
--
-
Q
A
Q
EP
TD
TPVSH
DDT
I
VVTA
-
A
E
Q
N
L
-
Q
AP
GV
S
---
-------------
T
I
T
A
DEIR
K
N
P
V
A
R
DVS
E
II
R
T
MPGVN
L
---
--
TGNST
S
G
Q
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
K
P
VS
S
R
NSV
RQGW
RGE
RDT
RG
DTSWVPPEM
I
E
R
I
EVLRGP
A
AA
R
YG
N
G
A
A
GG
V
V
NIITK
KG
SGEWH
G
SW
D
A
Y
F
NA
PE
H
KEEGATK
R
TN
FSLTGP
L
-
GD
EFSF
RLYG
NLD
--
KT
Q
A
D
AWD
IN
Q
--
G
HQSAR
AGTYATTLP
AGR
EG
V
I
N
K
DINGV
VR
WDF
AP
LQ
S
LELEA
G
YSRQGN
L
-
Y
AGD
TQ
NTNS
D
---------------
AY
T
RS
--
KY
G
D
-
E
T
NRL
Y
RQ
NY
S
LTWN
GG
WD
N
G
V
T
T
S
NWVQY
EH
-----------
TR
N
SR
IP
E
-
----
G
LA
G
-----
G
TEGKFNEK
A
TQDFVDN
D
L
D
D
V
M
L
H
SEV
N
-
-
-
LPIDF
L
V
--
NQT
----
--
--
--
--
--
LT
L
G
T
EWNQQ
R
M
KDLSS
N
TQA
L
TGT
N
T
---
GGA
I
--
D
G
V
S
A
TD
------------------
R
S
P
Y
SK
AE
I
F
S
L
F
A
EN
N
ME
LTD
S
T
I
V
T
P
GLRFD
H
H
SIVGN
N
WS
PALNISQGL
GD
D
-
---F
T
LKM
G
I
A
RA
----------------
Y
KA
P
S
LY
Q
TN
P
N
--
-
YI
L
Y
S
----
-
K
G
Q
G
CY
A
--
S
AG
GCYLQGND
D
L
KAE
T
SIN
K
EIG
L
EFK
RD
G
-
-
W
L
AG
I
T
W
FR
N
D
YR
NKIE
A
G
Y
V
AV
G
QN
AV
GT
DLYQ
W
D
N
V
P
KA
V
VEG
L
E
G
S
LN---V
P
-
VSE
TVM
W
TN
N
I
T
Y
MLK
S
E
N
K
T
T
----
-
-
-----
GDRL
S
II
PEY
TLN
S
TLSW
QA
RE
D
L
S
M
Q
TTF
T
W
YG
KQQ
P
KKY
-
N
Y
KG
QPAVG
P
ETKEIS
P
-
Y
SIV
G
L
S
AT
W
D
VTKN
V
S
LTGG
VDNLFD
K
R
L
WRAGNA
Q
T
T
G
DLA
GANY
I
A
GA
G
AYT
Y
N
-
E
PG
--
RT
WY
M
SV
NTHF
fig|637388.3.peg.1115
Escherichia coli O157:H7 str. FRIK2000
MNKKIHSL
A
LLVNL
G
IYGVA
--
-
Q
A
Q
EP
TD
TPVSH
DDT
I
VVTA
-
A
E
Q
N
L
-
Q
AP
GV
S
---
-------------
T
I
T
A
DEIR
K
N
P
V
A
R
DVS
E
II
R
T
MPGVN
L
---
--
TGNST
S
G
Q
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
K
P
VS
S
R
NSV
RQGW
RGE
RDT
RG
DTSWVPPEM
I
E
R
I
EVLRGP
A
AA
R
YG
N
G
A
A
GG
V
V
NIITK
KG
SGEWH
G
SW
D
A
Y
F
NA
PE
H
KEEGATK
R
TN
FSLTGP
L
-
GD
EFSF
RLYG
NLD
--
KT
Q
A
D
AWD
IN
Q
--
G
HQSAR
AGTYATTLP
AGR
EG
V
I
N
K
DINGV
VR
WDF
AP
LQ
S
LELEA
G
YSRQGN
L
-
Y
AGD
TQ
NTNS
D
---------------
AY
T
RS
--
KY
G
D
-
E
T
NRL
Y
RQ
NY
S
LTWN
GG
WD
N
G
V
T
T
S
NWVQY
EH
-----------
TR
N
SR
IP
E
-
----
G
LA
G
-----
G
TEGKFNEK
A
TQDFVDN
D
L
D
D
V
M
L
H
SEV
N
-
-
-
LPIDF
L
V
--
NQT
----
--
--
--
--
--
LT
L
G
T
EWNQQ
R
M
KDLSS
N
TQA
L
TGT
N
T
---
GGA
I
--
D
G
V
S
A
TD
------------------
R
S
P
Y
SK
AE
I
F
S
L
F
A
EN
N
ME
LTD
S
T
I
V
T
P
GLRFD
H
H
SIVGN
N
WS
PALNISQGL
GD
D
-
---F
T
LKM
G
I
A
RA
----------------
Y
KA
P
S
LY
Q
TN
P
N
--
-
YI
L
Y
S
----
-
K
G
Q
G
CY
A
--
S
AG
GCYLQGND
D
L
KAE
T
SIN
K
EIG
L
EFK
RD
G
-
-
W
L
AG
I
T
W
FR
N
D
YR
NKIE
A
G
Y
V
AV
G
QN
AV
GT
DLYQ
W
D
N
V
P
KA
V
VEG
L
E
G
S
LN---V
P
-
VSE
TVM
W
TN
N
I
T
Y
MLK
S
E
N
K
T
T
----
-
-
-----
GDRL
S
II
PEY
TLN
S
TLSW
QA
RE
D
L
S
M
Q
TTF
T
W
YG
KQQ
P
KKY
-
N
Y
KG
QPAVG
P
ETKEIS
P
-
Y
SIV
G
L
S
AT
W
D
VTKN
V
S
LTGG
VDNLFD
K
R
L
WRAGNA
Q
T
T
G
DLA
GANY
I
A
GA
G
AYT
Y
N
-
E
PG
--
RT
WY
M
SV
NTHF
fig|570506.3.peg.3652
Escherichia coli O157:H7 str. FRIK966
MNKKIHSL
A
LLVNL
G
IYGVA
--
-
Q
A
Q
EP
TD
TPVSH
DDT
I
VVTA
-
A
E
Q
N
L
-
Q
AP
GV
S
---
-------------
T
I
T
A
DEIR
K
N
P
V
A
R
DVS
E
II
R
T
MPGVN
L
---
--
TGNST
S
G
Q
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
K
P
VS
S
R
NSV
RQGW
RGE
RDT
RG
DTSWVPPEM
I
E
R
I
EVLRGP
A
AA
R
YG
N
G
A
A
GG
V
V
NIITK
KG
SGEWH
G
SW
D
A
Y
F
NA
PE
H
KEEGATK
R
TN
FSLTGP
L
-
GD
EFSF
RLYG
NLD
--
KT
Q
A
D
AWD
IN
Q
--
G
HQSAR
AGTYATTLP
AGR
EG
V
I
N
K
DINGV
VR
WDF
AP
LQ
S
LELEA
G
YSRQGN
L
-
Y
AGD
TQ
NTNS
D
---------------
AY
T
RS
--
KY
G
D
-
E
T
NRL
Y
RQ
NY
S
LTWN
GG
WD
N
G
V
T
T
S
NWVQY
EH
-----------
TR
N
SR
IP
E
-
----
G
LA
G
-----
G
TEGKFNEK
A
TQDFVDN
D
L
D
D
V
M
L
H
SEV
N
-
-
-
LPIDF
L
V
--
NQT
----
--
--
--
--
--
LT
L
G
T
EWNQQ
R
M
KDLSS
N
TQA
L
TGT
N
T
---
GGA
I
--
D
G
V
S
A
TD
------------------
R
S
P
Y
SK
AE
I
F
S
L
F
A
EN
N
ME
LTD
S
T
I
V
T
P
GLRFD
H
H
SIVGN
N
WS
PALNISQGL
GD
D
-
---F
T
LKM
G
I
A
RA
----------------
Y
KA
P
S
LY
Q
TN
P
N
--
-
YI
L
Y
S
----
-
K
G
Q
G
CY
A
--
S
AG
GCYLQGND
D
L
KAE
T
SIN
K
EIG
L
EFK
RD
G
-
-
W
L
AG
I
T
W
FR
N
D
YR
NKIE
A
G
Y
V
AV
G
QN
AV
GT
DLYQ
W
D
N
V
P
KA
V
VEG
L
E
G
S
LN---V
P
-
VSE
TVM
W
TN
N
I
T
Y
MLK
S
E
N
K
T
T
----
-
-
-----
GDRL
S
II
PEY
TLN
S
TLSW
QA
RE
D
L
S
M
Q
TTF
T
W
YG
KQQ
P
KKY
-
N
Y
KG
QPAVG
P
ETKEIS
P
-
Y
SIV
G
L
S
AT
W
D
VTKN
V
S
LTGG
VDNLFD
K
R
L
WRAGNA
Q
T
T
G
DLA
GANY
I
A
GA
G
AYT
Y
N
-
E
PG
--
RT
WY
M
SV
NTHF
fig|386585.9.peg.731
Escherichia coli O157:H7 str. Sakai
MNKKIHSL
A
LLVNL
G
IYGVA
--
-
Q
A
Q
EP
TD
TPVSH
DDT
I
VVTA
-
A
E
Q
N
L
-
Q
AP
GV
S
---
-------------
T
I
T
A
DEIR
K
N
P
V
A
R
DVS
E
II
R
T
MPGVN
L
---
--
TGNST
S
G
Q
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
K
P
VS
S
R
NSV
RQGW
RGE
RDT
RG
DTSWVPPEM
I
E
R
I
EVLRGP
A
AA
R
YG
N
G
A
A
GG
V
V
NIITK
KG
SGEWH
G
SW
D
A
Y
F
NA
PE
H
KEEGATK
R
TN
FSLTGP
L
-
GD
EFSF
RLYG
NLD
--
KT
Q
A
D
AWD
IN
Q
--
G
HQSAR
AGTYATTLP
AGR
EG
V
I
N
K
DINGV
VR
WDF
AP
LQ
S
LELEA
G
YSRQGN
L
-
Y
AGD
TQ
NTNS
D
---------------
AY
T
RS
--
KY
G
D
-
E
T
NRL
Y
RQ
NY
S
LTWN
GG
WD
N
G
V
T
T
S
NWVQY
EH
-----------
TR
N
SR
IP
E
-
----
G
LA
G
-----
G
TEGKFNEK
A
TQDFVDN
D
L
D
D
V
M
L
H
SEV
N
-
-
-
LPIDF
L
V
--
NQT
----
--
--
--
--
--
LT
L
G
T
EWNQQ
R
M
KDLSS
N
TQA
L
TGT
N
T
---
GGA
I
--
D
G
V
S
A
TD
------------------
R
S
P
Y
SK
AE
I
F
S
L
F
A
EN
N
ME
LTD
S
T
I
V
T
P
GLRFD
H
H
SIVGN
N
WS
PALNISQGL
GD
D
-
---F
T
LKM
G
I
A
RA
----------------
Y
KA
P
S
LY
Q
TN
P
N
--
-
YI
L
Y
S
----
-
K
G
Q
G
CY
A
--
S
AG
GCYLQGND
D
L
KAE
T
SIN
K
EIG
L
EFK
RD
G
-
-
W
L
AG
I
T
W
FR
N
D
YR
NKIE
A
G
Y
V
AV
G
QN
AV
GT
DLYQ
W
D
N
V
P
KA
V
VEG
L
E
G
S
LN---V
P
-
VSE
TVM
W
TN
N
I
T
Y
MLK
S
E
N
K
T
T
----
-
-
-----
GDRL
S
II
PEY
TLN
S
TLSW
QA
RE
D
L
S
M
Q
TTF
T
W
YG
KQQ
P
KKY
-
N
Y
KG
QPAVG
P
ETKEIS
P
-
Y
SIV
G
L
S
AT
W
D
VTKN
V
S
LTGG
VDNLFD
K
R
L
WRAGNA
Q
T
T
G
DLA
GANY
I
A
GA
G
AYT
Y
N
-
E
PG
--
RT
WY
M
SV
NTHF
fig|544404.4.peg.643
Escherichia coli O157:H7 str. TW14359
MNKKIHSL
A
LLVNL
G
IYGVA
--
-
Q
A
Q
EP
TD
TPVSH
DDT
I
VVTA
-
A
E
Q
N
L
-
Q
AP
GV
S
---
-------------
T
I
T
A
DEIR
K
N
P
V
A
R
DVS
E
II
R
T
MPGVN
L
---
--
TGNST
S
G
Q
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
K
P
VS
S
R
NSV
RQGW
RGE
RDT
RG
DTSWVPPEM
I
E
R
I
EVLRGP
A
AA
R
YG
N
G
A
A
GG
V
V
NIITK
KG
SGEWH
G
SW
D
A
Y
F
NA
PE
H
KEEGATK
R
TN
FSLTGP
L
-
GD
EFSF
RLYG
NLD
--
KT
Q
A
D
AWD
IN
Q
--
G
HQSAR
AGTYATTLP
AGR
EG
V
I
N
K
DINGV
VR
WDF
AP
LQ
S
LELEA
G
YSRQGN
L
-
Y
AGD
TQ
NTNS
D
---------------
AY
T
RS
--
KY
G
D
-
E
T
NRL
Y
RQ
NY
S
LTWN
GG
WD
N
G
V
T
T
S
NWVQY
EH
-----------
TR
N
SR
IP
E
-
----
G
LA
G
-----
G
TEGKFNEK
A
TQDFVDN
D
L
D
D
V
M
L
H
SEV
N
-
-
-
LPIDF
L
V
--
NQT
----
--
--
--
--
--
LT
L
G
T
EWNQQ
R
M
KDLSS
N
TQA
L
TGT
N
T
---
GGA
I
--
D
G
V
S
A
TD
------------------
R
S
P
Y
SK
AE
I
F
S
L
F
A
EN
N
ME
LTD
S
T
I
V
T
P
GLRFD
H
H
SIVGN
N
WS
PALNISQGL
GD
D
-
---F
T
LKM
G
I
A
RA
----------------
Y
KA
P
S
LY
Q
TN
P
N
--
-
YI
L
Y
S
----
-
K
G
Q
G
CY
A
--
S
AG
GCYLQGND
D
L
KAE
T
SIN
K
EIG
L
EFK
RD
G
-
-
W
L
AG
I
T
W
FR
N
D
YR
NKIE
A
G
Y
V
AV
G
QN
AV
GT
DLYQ
W
D
N
V
P
KA
V
VEG
L
E
G
S
LN---V
P
-
VSE
TVM
W
TN
N
I
T
Y
MLK
S
E
N
K
T
T
----
-
-
-----
GDRL
S
II
PEY
TLN
S
TLSW
QA
RE
D
L
S
M
Q
TTF
T
W
YG
KQQ
P
KKY
-
N
Y
KG
QPAVG
P
ETKEIS
P
-
Y
SIV
G
L
S
AT
W
D
VTKN
V
S
LTGG
VDNLFD
K
R
L
WRAGNA
Q
T
T
G
DLA
GANY
I
A
GA
G
AYT
Y
N
-
E
PG
--
RT
WY
M
SV
NTHF
fig|502346.5.peg.578
Escherichia coli O157:H7 str. TW14588
MNKKIHSL
A
LLVNL
G
IYGVA
--
-
Q
A
Q
EP
TD
TPVSH
DDT
I
VVTA
-
A
E
Q
N
L
-
Q
AP
GV
S
---
-------------
T
I
T
A
DEIR
K
N
P
V
A
R
DVS
E
II
R
T
MPGVN
L
---
--
TGNST
S
G
Q
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
K
P
VS
S
R
NSV
RQGW
RGE
RDT
RG
DTSWVPPEM
I
E
R
I
EVLRGP
A
AA
R
YG
N
G
A
A
GG
V
V
NIITK
KG
SGEWH
G
SW
D
A
Y
F
NA
PE
H
KEEGATK
R
TN
FSLTGP
L
-
GD
EFSF
RLYG
NLD
--
KT
Q
A
D
AWD
IN
Q
--
G
HQSAR
AGTYATTLP
AGR
EG
V
I
N
K
DINGV
VR
WDF
AP
LQ
S
LELEA
G
YSRQGN
L
-
Y
AGD
TQ
NTNS
D
---------------
AY
T
RS
--
KY
G
D
-
E
T
NRL
Y
RQ
NY
S
LTWN
GG
WD
N
G
V
T
T
S
NWVQY
EH
-----------
TR
N
SR
IP
E
-
----
G
LA
G
-----
G
TEGKFNEK
A
TQDFVDN
D
L
D
D
V
M
L
H
SEV
N
-
-
-
LPIDF
L
V
--
NQT
----
--
--
--
--
--
LT
L
G
T
EWNQQ
R
M
KDLSS
N
TQA
L
TGT
N
T
---
GGA
I
--
D
G
V
S
A
TD
------------------
R
S
P
Y
SK
AE
I
F
S
L
F
A
EN
N
ME
LTD
S
T
I
V
T
P
GLRFD
H
H
SIVGN
N
WS
PALNISQGL
GD
D
-
---F
T
LKM
G
I
A
RA
----------------
Y
KA
P
S
LY
Q
TN
P
N
--
-
YI
L
Y
S
----
-
K
G
Q
G
CY
A
--
S
AG
GCYLQGND
D
L
KAE
T
SIN
K
EIG
L
EFK
RD
G
-
-
W
L
AG
I
T
W
FR
N
D
YR
NKIE
A
G
Y
V
AV
G
QN
AV
GT
DLYQ
W
D
N
V
P
KA
V
VEG
L
E
G
S
LN---V
P
-
VSE
TVM
W
TN
N
I
T
Y
MLK
S
E
N
K
T
T
----
-
-
-----
GDRL
S
II
PEY
TLN
S
TLSW
QA
RE
D
L
S
M
Q
TTF
T
W
YG
KQQ
P
KKY
-
N
Y
KG
QPAVG
P
ETKEIS
P
-
Y
SIV
G
L
S
AT
W
D
VTKN
V
S
LTGG
VDNLFD
K
R
L
WRAGNA
Q
T
T
G
DLA
GANY
I
A
GA
G
AYT
Y
N
-
E
PG
--
RT
WY
M
SV
NTHF
fig|701177.3.peg.743
Escherichia coli O55:H7 str. CB9615
MNKKIHSL
A
LLVNL
G
IYGVA
--
-
Q
A
Q
EP
TD
TPVSH
DDT
I
VVTA
-
A
E
Q
N
L
-
Q
AP
GV
S
---
-------------
T
I
T
A
DEIR
K
N
P
V
A
R
DVS
E
II
R
T
MPGVN
L
---
--
TGNST
S
G
Q
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
K
P
VS
S
R
NSV
RQGW
RGE
RDT
RG
DTSWVPPEM
I
E
R
I
EVLRGP
A
AA
R
YG
N
G
A
A
GG
V
V
NIITK
KG
SGEWH
G
SW
D
A
Y
F
NA
PE
H
KEEGATK
R
TN
FSLTGP
L
-
GD
EFSF
RLYG
NLD
--
KT
Q
A
D
AWD
IN
Q
--
G
HQSAR
AGTYATTLP
AGR
EG
V
I
N
K
DINGV
VR
WDF
AP
LQ
S
LELEA
G
YSRQGN
L
-
Y
AGD
TQ
NTNS
D
---------------
AY
T
RS
--
KY
G
D
-
E
T
NRL
Y
RQ
NY
S
LTWN
GG
WD
N
G
V
T
T
S
NWVQY
EH
-----------
TR
N
SR
IP
E
-
----
G
LA
G
-----
G
TEGKFNEK
A
TQDFVDN
D
L
D
D
V
M
L
H
SEV
N
-
-
-
LPIDF
L
V
--
NQT
----
--
--
--
--
--
LT
L
G
T
EWNQQ
R
M
KDLSS
N
TQA
L
TGT
N
T
---
GGA
I
--
D
G
V
S
A
TD
------------------
R
S
P
Y
SK
AE
I
F
S
L
F
A
EN
N
ME
LTD
S
T
I
V
T
P
GLRFD
H
H
SIVGN
N
WS
PALNISQGL
GD
D
-
---F
T
LKM
G
I
A
RA
----------------
Y
KA
P
S
LY
Q
TN
P
N
--
-
YI
L
Y
S
----
-
K
G
Q
G
CY
A
--
S
AG
GCYLQGND
D
L
KAE
T
SIN
K
EIG
L
EFK
RD
G
-
-
W
L
AG
I
T
W
FR
N
D
YR
NKIE
A
G
Y
V
AV
G
QN
AV
GT
DLYQ
W
D
N
V
P
KA
V
VEG
L
E
G
S
LN---V
P
-
VSE
TVM
W
TN
N
I
T
Y
MLK
S
E
N
K
T
T
----
-
-
-----
GDRL
S
II
PEY
TLN
S
TLSW
QA
RE
D
L
S
M
Q
TTF
T
W
YG
KQQ
P
KKY
-
N
Y
KG
QPAVG
P
ETKEIS
P
-
Y
SIV
G
L
S
AT
W
D
VTKN
V
S
LTGG
VDNLFD
K
R
L
WRAGNA
Q
T
T
G
DLA
GANY
I
A
GA
G
AYT
Y
N
-
E
PG
--
RT
WY
M
SV
NTHF
fig|656444.3.peg.1059
Escherichia coli TA280
MNKKIHSL
A
LLVNL
G
IYGVA
--
-
Q
A
Q
EP
TD
TPVSH
DDT
I
VVTA
-
A
E
Q
N
L
-
Q
AP
GV
S
---
-------------
T
I
T
A
DEIR
K
N
P
V
A
R
DVS
E
II
R
T
MPGVN
L
---
--
TGNST
S
G
Q
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
K
P
VS
S
R
NSV
RQGW
RGE
RDT
RG
DTSWVPPEM
I
E
R
I
EVLRGP
A
AA
R
YG
N
G
A
A
GG
V
V
NIITK
KG
SGEWH
G
SW
D
A
Y
F
NA
PE
H
KEEGATK
R
TN
FSLTGP
L
-
GD
EFSF
RLYG
NLD
--
KT
Q
A
D
AWD
IN
Q
--
G
HQSAR
AGTYATTLP
AGR
EG
V
I
N
K
DINGV
VR
WDL
AP
LQ
S
LELEA
G
YSRQGN
L
-
Y
AGD
TQ
NTNS
D
---------------
SY
T
RS
--
KY
G
D
-
E
T
NRL
Y
RQ
NY
S
LTWN
GG
WD
N
G
V
T
T
S
NWVQY
EH
-----------
TR
N
SR
IP
E
-
----
G
LA
G
-----
G
TEGKFNEK
A
TQDFVDI
D
L
D
D
V
M
L
H
SEV
N
-
-
-
LPIDF
L
V
--
NQT
----
--
--
--
--
--
LT
L
G
T
EWNQQ
R
M
KDLSS
N
TQA
L
TGT
N
T
---
GGA
I
--
D
G
V
S
A
TD
------------------
R
S
P
Y
SK
AE
I
F
S
L
F
A
EN
N
ME
LTD
S
T
I
V
T
P
GLRFD
H
H
SIVGN
N
WS
PALNISQGL
GD
D
-
---F
T
LKM
G
I
A
RA
----------------
Y
KA
P
S
LY
Q
TN
P
N
--
-
YI
L
Y
S
----
-
K
G
Q
G
CY
A
--
S
AG
GCYLQGND
D
L
KAE
T
SIN
K
EIG
L
EFK
RD
G
-
-
W
L
AG
I
T
W
FR
N
D
YR
NKIE
A
G
Y
V
AV
G
QN
AV
GT
DLYQ
W
D
N
V
P
KA
V
VEG
L
E
G
S
LN---V
P
-
VSE
TVM
W
TN
N
I
T
Y
MLK
S
E
N
K
T
T
----
-
-
-----
GDRL
S
II
PEY
TLN
S
TLSW
QA
RE
D
L
S
M
Q
TTF
T
W
YG
KQQ
P
KKY
-
N
Y
KG
QPAVG
P
ETKEIS
P
-
Y
SIV
G
L
S
AT
W
D
VTKN
V
S
LTGG
VDNLFD
K
R
L
WRAGNA
Q
T
T
G
DLA
GANY
I
A
GA
G
AYT
Y
N
-
E
PG
--
RT
WY
M
SI
NTHF
fig|749547.3.peg.3575
Escherichia coli MS 187-1
MNKKIHSL
A
LLVNL
G
IYGVA
--
-
Q
A
Q
EP
TD
TPVSH
DDT
I
VVTA
-
A
E
Q
N
L
-
Q
AP
GV
S
---
-------------
T
I
T
A
DEIR
K
N
P
V
A
R
DVS
E
II
R
T
MPGVN
L
---
--
TGNST
S
G
Q
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
K
P
VS
S
R
NSV
RQGW
RGE
RDT
RG
DTSWVPPEM
I
E
R
I
EVLRGP
A
AA
R
YG
N
G
A
A
GG
V
V
NIITK
KG
SGEWH
G
SW
G
A
Y
F
NA
PE
H
KEEGATK
R
TN
FSLTGP
L
-
GD
EFSF
RLYG
NLD
--
KT
Q
A
D
AWD
IN
Q
--
G
HQSAR
AGTYATTLP
AGR
EG
V
I
N
K
DINGV
VR
WDF
AP
LQ
S
LELEA
G
YSRQGN
L
-
Y
AGD
TQ
NTNS
D
---------------
SY
T
RS
--
KY
G
D
-
E
T
NRL
Y
RQ
NY
A
LTWN
GG
WD
N
G
V
T
T
S
NWVQY
EH
-----------
TR
N
SR
IP
E
-
----
G
LA
G
-----
G
TEGKFNEK
A
TQDFVDI
D
L
D
D
V
M
L
H
SEV
N
-
-
-
LPIDF
L
V
--
NQT
----
--
--
--
--
--
LT
L
G
T
EWNQQ
R
M
KDLSS
N
TQA
L
TGT
N
T
---
GGA
I
--
D
G
V
S
T
TD
------------------
R
S
P
Y
SK
AE
I
F
S
L
F
A
EN
N
ME
LTD
S
T
I
V
T
P
GLRFD
H
H
SIVGN
N
WS
PALNISQGL
GD
D
-
---F
T
LKM
G
I
A
RA
----------------
Y
KA
P
S
LY
Q
TN
P
N
--
-
YI
L
Y
S
----
-
K
G
Q
G
CY
A
--
S
AG
GCYLQGND
D
L
KAE
T
SIN
K
EIG
L
EFK
RD
G
-
-
W
L
AG
V
T
W
FR
N
D
YR
NKIE
A
G
Y
V
AV
G
QN
AV
GT
DLYQ
W
D
N
V
P
KA
V
VEG
L
E
G
S
LN---V
P
-
VSE
TVM
W
TN
N
I
T
Y
MLK
S
E
N
K
T
T
----
-
-
-----
GDRL
S
II
PEY
TLN
S
TLSW
QA
RE
D
L
S
M
Q
TTF
T
W
YG
KQQ
P
KKY
-
N
Y
KG
QPAVG
P
ETKEIS
P
-
Y
SIV
G
L
S
AT
W
D
VTKN
V
S
LTGG
VDNLFD
K
R
L
WRAGNA
Q
T
T
G
DLA
GANY
I
A
GA
G
AYT
Y
N
-
E
PG
--
RT
WY
M
SV
NTHF
fig|155864.8.peg.633
Escherichia coli O157:H7 EDL933
MNKKIHSL
A
LLVNL
G
IYGVA
--
-
Q
A
Q
XP
TD
TPVSH
DDT
I
VVTA
-
A
E
Q
N
L
-
Q
AP
GV
S
---
-------------
T
I
T
A
DEIR
K
N
P
V
A
R
DVS
E
II
R
T
MPGVN
L
---
--
TGNST
S
G
Q
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
K
P
VS
S
R
NSV
RQGW
RGE
RDT
RG
DTSWVPPEM
I
E
R
I
EVLRGP
A
AA
R
YG
N
G
A
A
GG
V
V
NIITK
KG
SGEWH
G
SW
D
A
Y
F
NA
PE
H
KEEGATK
R
TN
FSLTGP
L
-
GD
EFSF
RLYG
NLD
--
KT
Q
A
D
AWD
IN
Q
--
G
HQSAR
AGTYATTLP
AGR
EG
V
I
N
K
DINGV
VR
WDF
AP
LQ
S
LELEA
G
YSRQGN
L
-
Y
AGD
TQ
NTNS
D
---------------
AY
T
RS
--
KY
G
D
-
E
T
NRL
Y
RQ
NY
S
LTWN
GG
WD
N
G
V
T
T
S
NWVQY
EH
-----------
TR
N
SR
IP
E
-
----
G
LA
G
-----
G
TEGKFNEK
A
TQDFVDN
D
L
D
D
V
M
L
H
SEV
N
-
-
-
LPIDF
L
V
--
NQT
----
--
--
--
--
--
LT
L
G
T
EWNQQ
R
M
KDLSS
N
TQA
L
TGT
N
T
---
GGA
I
--
D
G
V
S
A
TD
------------------
R
S
P
Y
SK
AE
I
F
S
L
F
A
EN
N
ME
LTD
S
T
I
V
T
P
GLRFD
H
H
SIVGN
N
WS
PALNISQGL
GD
D
-
---F
T
LKM
G
I
A
RA
----------------
Y
KA
P
S
LY
Q
TN
P
N
--
-
YI
L
Y
S
----
-
K
G
Q
G
CY
A
--
S
AG
GCYLQGND
D
L
KAE
T
SIN
K
EIG
L
EFK
RD
G
-
-
W
L
AG
I
T
W
FR
N
D
YR
NKIE
A
G
Y
V
AV
G
QN
AV
GT
DLYQ
W
D
N
V
P
KA
V
VEG
L
E
G
S
LN---V
P
-
VSE
TVM
W
TN
N
I
T
Y
MLK
S
E
N
K
T
T
----
-
-
-----
GDRL
S
II
PEY
TLN
S
TLSW
QA
RE
D
L
S
M
Q
TTF
T
W
YG
KQQ
P
KKY
-
N
Y
KG
QPAVG
P
ETKEIS
P
-
Y
SIV
G
L
S
AT
W
D
VTKN
V
S
LTGG
VDNLFD
K
R
L
WRAGNA
Q
T
T
G
DLA
GANY
I
A
GA
G
AYT
Y
N
-
E
PG
--
RT
WY
M
SV
NTHF
fig|362663.8.peg.618
Escherichia coli 536 (23-771/771)
MNKKIHSL
A
LLVNL
G
IYGVA
L
P
V
L
A
E
ET
S
D
NAVSH
DDT
I
VVTA
-
A
E
Q
N
L
-
Q
AP
GV
S
---
-------------
T
I
T
A
DEIR
K
N
P
V
A
R
DVS
E
II
R
T
MPGVN
L
---
--
TGNST
S
G
Q
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
K
P
VS
S
R
NSV
RQGW
RGE
RDT
RG
DTSWVPPEM
I
E
R
I
EVLRGP
A
AA
R
YG
N
G
A
A
GG
V
V
NIITK
KG
SGEWH
G
SW
D
A
Y
F
NA
PE
H
KEEGATK
R
TN
FSLTGP
L
-
GD
EFSF
RLYG
NLD
--
KT
Q
A
D
AWD
IN
Q
--
G
HQSAR
AGTYATTLP
AGR
EG
V
I
N
K
DINGV
VR
WDF
AP
LQ
S
LELEA
G
YSRQGN
L
-
Y
AGD
TQ
NTNS
D
---------------
AY
T
RS
--
KY
G
D
-
E
T
NRL
Y
RQ
NY
S
LTWN
GG
WD
N
G
V
T
T
S
NWVQY
EH
-----------
TR
N
SR
IP
E
-
----
G
LA
G
-----
G
TEGKFNEK
A
AQDFVDI
D
L
D
D
V
M
L
H
SEV
N
-
-
-
LPIDF
L
V
--
NQT
----
--
--
--
--
--
LT
L
G
T
EWNQQ
R
M
KDLSS
N
TQA
L
TGT
N
T
---
GGA
I
--
D
G
V
S
A
TD
------------------
R
S
P
Y
SK
AE
I
F
S
L
F
A
EN
N
ME
LTD
S
T
I
V
T
P
GLRFD
H
H
SIVGN
N
WS
PALNISQSL
GD
D
-
---F
T
LKM
G
I
A
RA
----------------
Y
KA
P
S
LY
Q
TN
P
N
--
-
YI
L
Y
S
----
-
K
G
Q
G
CY
A
--
S
AG
GCYLQGND
D
L
KAE
T
SIN
K
EIG
L
EFK
RD
G
-
-
W
L
AG
V
T
W
FR
N
D
YR
NKIE
A
G
Y
V
AV
G
QN
AV
GT
DLYQ
W
D
N
V
P
KA
V
VEG
L
E
G
S
LN---V
P
-
VSE
TVM
W
TN
N
I
T
Y
MLK
S
E
N
K
T
T
----
-
-
-----
GDRL
S
II
PEY
TLN
S
TLSW
QA
RE
D
L
S
M
Q
TTF
T
W
YG
KQQ
P
KKY
-
N
Y
KG
QPAVG
P
ETKEIS
P
-
Y
SIV
G
L
S
AT
W
D
VTKN
V
S
LTGG
VDNLFD
K
R
L
WRAGNA
Q
T
T
G
DLA
GANY
I
A
GA
G
AYT
Y
N
-
E
PG
--
RT
WY
M
SI
NTHF
fig|362663.9.peg.619
Escherichia coli 536 (23-771/771)
MNKKIHSL
A
LLVNL
G
IYGVA
L
P
V
L
A
E
ET
S
D
NAVSH
DDT
I
VVTA
-
A
E
Q
N
L
-
Q
AP
GV
S
---
-------------
T
I
T
A
DEIR
K
N
P
V
A
R
DVS
E
II
R
T
MPGVN
L
---
--
TGNST
S
G
Q
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
K
P
VS
S
R
NSV
RQGW
RGE
RDT
RG
DTSWVPPEM
I
E
R
I
EVLRGP
A
AA
R
YG
N
G
A
A
GG
V
V
NIITK
KG
SGEWH
G
SW
D
A
Y
F
NA
PE
H
KEEGATK
R
TN
FSLTGP
L
-
GD
EFSF
RLYG
NLD
--
KT
Q
A
D
AWD
IN
Q
--
G
HQSAR
AGTYATTLP
AGR
EG
V
I
N
K
DINGV
VR
WDF
AP
LQ
S
LELEA
G
YSRQGN
L
-
Y
AGD
TQ
NTNS
D
---------------
AY
T
RS
--
KY
G
D
-
E
T
NRL
Y
RQ
NY
S
LTWN
GG
WD
N
G
V
T
T
S
NWVQY
EH
-----------
TR
N
SR
IP
E
-
----
G
LA
G
-----
G
TEGKFNEK
A
AQDFVDI
D
L
D
D
V
M
L
H
SEV
N
-
-
-
LPIDF
L
V
--
NQT
----
--
--
--
--
--
LT
L
G
T
EWNQQ
R
M
KDLSS
N
TQA
L
TGT
N
T
---
GGA
I
--
D
G
V
S
A
TD
------------------
R
S
P
Y
SK
AE
I
F
S
L
F
A
EN
N
ME
LTD
S
T
I
V
T
P
GLRFD
H
H
SIVGN
N
WS
PALNISQSL
GD
D
-
---F
T
LKM
G
I
A
RA
----------------
Y
KA
P
S
LY
Q
TN
P
N
--
-
YI
L
Y
S
----
-
K
G
Q
G
CY
A
--
S
AG
GCYLQGND
D
L
KAE
T
SIN
K
EIG
L
EFK
RD
G
-
-
W
L
AG
V
T
W
FR
N
D
YR
NKIE
A
G
Y
V
AV
G
QN
AV
GT
DLYQ
W
D
N
V
P
KA
V
VEG
L
E
G
S
LN---V
P
-
VSE
TVM
W
TN
N
I
T
Y
MLK
S
E
N
K
T
T
----
-
-
-----
GDRL
S
II
PEY
TLN
S
TLSW
QA
RE
D
L
S
M
Q
TTF
T
W
YG
KQQ
P
KKY
-
N
Y
KG
QPAVG
P
ETKEIS
P
-
Y
SIV
G
L
S
AT
W
D
VTKN
V
S
LTGG
VDNLFD
K
R
L
WRAGNA
Q
T
T
G
DLA
GANY
I
A
GA
G
AYT
Y
N
-
E
PG
--
RT
WY
M
SI
NTHF
fig|340197.5.peg.2540
Escherichia coli F11 (23-771/771)
MNKKIHSL
A
LLVNL
G
IYGVA
L
P
V
L
A
E
ET
S
D
NAVSH
DDT
I
VVTA
-
A
E
Q
N
L
-
Q
AP
GV
S
---
-------------
T
I
T
A
DEIR
K
N
P
V
A
R
DVS
E
II
R
T
MPGVN
L
---
--
TGNST
S
G
Q
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
K
P
VS
S
R
NSV
RQGW
RGE
RDT
RG
DTSWVPPEM
I
E
R
I
EVLRGP
A
AA
R
YG
N
G
A
A
GG
V
V
NIITK
KG
SGEWH
G
SW
D
A
Y
F
NA
PE
H
KEEGATK
R
TN
FSLTGP
L
-
GD
EFSF
RLYG
NLD
--
KT
Q
A
D
AWD
IN
Q
--
G
HQSAR
AGTYATTLP
AGR
EG
V
I
N
K
DINGV
VR
WDF
AP
LQ
S
LELEA
G
YSRQGN
L
-
Y
AGD
TQ
NTNS
D
---------------
AY
T
RS
--
KY
G
D
-
E
T
NRL
Y
RQ
NY
S
LTWN
GG
WD
N
G
V
T
T
S
NWVQY
EH
-----------
TR
N
SR
IP
E
-
----
G
LA
G
-----
G
TEGKFNEK
A
AQDFVDI
D
L
D
D
V
M
L
H
SEV
N
-
-
-
LPIDF
L
V
--
NQT
----
--
--
--
--
--
LT
L
G
T
EWNQQ
R
M
KDLSS
N
TQA
L
TGT
N
T
---
GGA
I
--
D
G
V
S
A
TD
------------------
R
S
P
Y
SK
AE
I
F
S
L
F
A
EN
N
ME
LTD
S
T
I
V
T
P
GLRFD
H
H
SIVGN
N
WS
PALNISQSL
GD
D
-
---F
T
LKM
G
I
A
RA
----------------
Y
KA
P
S
LY
Q
TN
P
N
--
-
YI
L
Y
S
----
-
K
G
Q
G
CY
A
--
S
AG
GCYLQGND
D
L
KAE
T
SIN
K
EIG
L
EFK
RD
G
-
-
W
L
AG
V
T
W
FR
N
D
YR
NKIE
A
G
Y
V
AV
G
QN
AV
GT
DLYQ
W
D
N
V
P
KA
V
VEG
L
E
G
S
LN---V
P
-
VSE
TVM
W
TN
N
I
T
Y
MLK
S
E
N
K
T
T
----
-
-
-----
GDRL
S
II
PEY
TLN
S
TLSW
QA
RE
D
L
S
M
Q
TTF
T
W
YG
KQQ
P
KKY
-
N
Y
KG
QPAVG
P
ETKEIS
P
-
Y
SIV
G
L
S
AT
W
D
VTKN
V
S
LTGG
VDNLFD
K
R
L
WRAGNA
Q
T
T
G
DLA
GANY
I
A
GA
G
AYT
Y
N
-
E
PG
--
RT
WY
M
SI
NTHF
fig|749550.3.peg.4864
Escherichia coli MS 200-1 (23-771/771)
MNKKIHSL
A
LLVNL
G
IYGVA
L
P
V
L
A
E
ET
S
D
NAVSH
DDT
I
VVTA
-
A
E
Q
N
L
-
Q
AP
GV
S
---
-------------
T
I
T
A
DEIR
K
N
P
V
A
R
DVS
E
II
R
T
MPGVN
L
---
--
TGNST
S
G
Q
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
K
P
VS
S
R
NSV
RQGW
RGE
RDT
RG
DTSWVPPEM
I
E
R
I
EVLRGP
A
AA
R
YG
N
G
A
A
GG
V
V
NIITK
KG
SGEWH
G
SW
D
A
Y
F
NA
PE
H
KEEGATK
R
TN
FSLTGP
L
-
GD
EFSF
RLYG
NLD
--
KT
Q
A
D
AWD
IN
Q
--
G
HQSAR
AGTYATTLP
AGR
EG
V
I
N
K
DINGV
VR
WDF
AP
LQ
S
LELEA
G
YSRQGN
L
-
Y
AGD
TQ
NTNS
D
---------------
AY
T
RS
--
KY
G
D
-
E
T
NRL
Y
RQ
NY
S
LTWN
GG
WD
N
G
V
T
T
S
NWVQY
EH
-----------
TR
N
SR
IP
E
-
----
G
LA
G
-----
G
TEGKFNEK
A
AQDFVDI
D
L
D
D
V
M
L
H
SEV
N
-
-
-
LPIDF
L
V
--
NQT
----
--
--
--
--
--
LT
L
G
T
EWNQQ
R
M
KDLSS
N
TQA
L
TGT
N
T
---
GGA
I
--
D
G
V
S
A
TD
------------------
R
S
P
Y
SK
AE
I
F
S
L
F
A
EN
N
ME
LTD
S
T
I
V
T
P
GLRFD
H
H
SIVGN
N
WS
PALNISQSL
GD
D
-
---F
T
LKM
G
I
A
RA
----------------
Y
KA
P
S
LY
Q
TN
P
N
--
-
YI
L
Y
S
----
-
K
G
Q
G
CY
A
--
S
AG
GCYLQGND
D
L
KAE
T
SIN
K
EIG
L
EFK
RD
G
-
-
W
L
AG
V
T
W
FR
N
D
YR
NKIE
A
G
Y
V
AV
G
QN
AV
GT
DLYQ
W
D
N
V
P
KA
V
VEG
L
E
G
S
LN---V
P
-
VSE
TVM
W
TN
N
I
T
Y
MLK
S
E
N
K
T
T
----
-
-
-----
GDRL
S
II
PEY
TLN
S
TLSW
QA
RE
D
L
S
M
Q
TTF
T
W
YG
KQQ
P
KKY
-
N
Y
KG
QPAVG
P
ETKEIS
P
-
Y
SIV
G
L
S
AT
W
D
VTKN
V
S
LTGG
VDNLFD
K
R
L
WRAGNA
Q
T
T
G
DLA
GANY
I
A
GA
G
AYT
Y
N
-
E
PG
--
RT
WY
M
SI
NTHF
fig|753642.3.peg.1073
Escherichia coli NC101 (23-771/771)
MNKKIHSL
A
LLVNL
G
IYGVA
L
P
V
L
A
E
ET
S
D
NAVSH
DDT
I
VVTA
-
A
E
Q
N
L
-
Q
AP
GV
S
---
-------------
T
I
T
A
DEIR
K
N
P
V
A
R
DVS
E
II
R
T
MPGVN
L
---
--
TGNST
S
G
Q
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
K
P
VS
S
R
NSV
RQGW
RGE
RDT
RG
DTSWVPPEM
I
E
R
I
EVLRGP
A
AA
R
YG
N
G
A
A
GG
V
V
NIITK
KG
SGEWH
G
SW
D
A
Y
F
NA
PE
H
KEEGATK
R
TN
FSLTGP
L
-
GD
EFSF
RLYG
NLD
--
KT
Q
A
D
AWD
IN
Q
--
G
HQSAR
AGTYATTLP
AGR
EG
V
I
N
K
DINGV
VR
WDF
AP
LQ
S
LELEA
G
YSRQGN
L
-
Y
AGD
TQ
NTNS
D
---------------
AY
T
RS
--
KY
G
D
-
E
T
NRL
Y
RQ
NY
S
LTWN
GG
WD
N
G
V
T
T
S
NWVQY
EH
-----------
TR
N
SR
IP
E
-
----
G
LA
G
-----
G
TEGKFNEK
A
AQDFVDI
D
L
D
D
V
M
L
H
SEV
N
-
-
-
LPIDF
L
V
--
NQT
----
--
--
--
--
--
LT
L
G
T
EWNQQ
R
M
KDLSS
N
TQA
L
TGT
N
T
---
GGA
I
--
D
G
V
S
A
TD
------------------
R
S
P
Y
SK
AE
I
F
S
L
F
A
EN
N
ME
LTD
S
T
I
V
T
P
GLRFD
H
H
SIVGN
N
WS
PALNISQSL
GD
D
-
---F
T
LKM
G
I
A
RA
----------------
Y
KA
P
S
LY
Q
TN
P
N
--
-
YI
L
Y
S
----
-
K
G
Q
G
CY
A
--
S
AG
GCYLQGND
D
L
KAE
T
SIN
K
EIG
L
EFK
RD
G
-
-
W
L
AG
V
T
W
FR
N
D
YR
NKIE
A
G
Y
V
AV
G
QN
AV
GT
DLYQ
W
D
N
V
P
KA
V
VEG
L
E
G
S
LN---V
P
-
VSE
TVM
W
TN
N
I
T
Y
MLK
S
E
N
K
T
T
----
-
-
-----
GDRL
S
II
PEY
TLN
S
TLSW
QA
RE
D
L
S
M
Q
TTF
T
W
YG
KQQ
P
KKY
-
N
Y
KG
QPAVG
P
ETKEIS
P
-
Y
SIV
G
L
S
AT
W
D
VTKN
V
S
LTGG
VDNLFD
K
R
L
WRAGNA
Q
T
T
G
DLA
GANY
I
A
GA
G
AYT
Y
N
-
E
PG
--
RT
WY
M
SI
NTHF
fig|685038.3.peg.529
Escherichia coli O83:H1 str. NRG 857C (23-771/771)
MNKKIHSL
A
LLVNL
G
IYGVA
L
P
V
L
A
E
ET
S
D
NAVSH
DDT
I
VVTA
-
A
E
Q
N
L
-
Q
AP
GV
S
---
-------------
T
I
T
A
DEIR
K
N
P
V
A
R
DVS
E
II
R
T
MPGVN
L
---
--
TGNST
S
G
Q
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
K
P
VS
S
R
NSV
RQGW
RGE
RDT
RG
DTSWVPPEM
I
E
R
I
EVLRGP
A
AA
R
YG
N
G
A
A
GG
V
V
NIITK
KG
SGEWH
G
SW
D
A
Y
F
NA
PE
H
KEEGATK
R
TN
FSLTGP
L
-
GD
EFSF
RLYG
NLD
--
KT
Q
A
D
AWD
IN
Q
--
G
HQSAR
AGTYATTLP
AGR
EG
V
I
N
K
DINGV
VR
WDF
AP
LQ
S
LELEA
G
YSRQGN
L
-
Y
AGD
TQ
NTNS
D
---------------
AY
T
RS
--
KY
G
D
-
E
T
NRL
Y
RQ
NY
S
LTWN
GG
WD
N
G
V
T
T
S
NWVQY
EH
-----------
TR
N
SR
IP
E
-
----
G
LA
G
-----
G
TEGKFNEK
A
AQDFVDI
D
L
D
D
V
M
L
H
SEV
N
-
-
-
LPIDF
L
V
--
NQT
----
--
--
--
--
--
LT
L
G
T
EWNQQ
R
M
KDLSS
N
TQA
L
TGT
N
T
---
GGA
I
--
D
G
V
S
A
TD
------------------
R
S
P
Y
SK
AE
I
F
S
L
F
A
EN
N
ME
LTD
S
T
I
V
T
P
GLRFD
H
H
SIVGN
N
WS
PALNISQSL
GD
D
-
---F
T
LKM
G
I
A
RA
----------------
Y
KA
P
S
LY
Q
TN
P
N
--
-
YI
L
Y
S
----
-
K
G
Q
G
CY
A
--
S
AG
GCYLQGND
D
L
KAE
T
SIN
K
EIG
L
EFK
RD
G
-
-
W
L
AG
V
T
W
FR
N
D
YR
NKIE
A
G
Y
V
AV
G
QN
AV
GT
DLYQ
W
D
N
V
P
KA
V
VEG
L
E
G
S
LN---V
P
-
VSE
TVM
W
TN
N
I
T
Y
MLK
S
E
N
K
T
T
----
-
-
-----
GDRL
S
II
PEY
TLN
S
TLSW
QA
RE
D
L
S
M
Q
TTF
T
W
YG
KQQ
P
KKY
-
N
Y
KG
QPAVG
P
ETKEIS
P
-
Y
SIV
G
L
S
AT
W
D
VTKN
V
S
LTGG
VDNLFD
K
R
L
WRAGNA
Q
T
T
G
DLA
GANY
I
A
GA
G
AYT
Y
N
-
E
PG
--
RT
WY
M
SI
NTHF
fig|340197.3.peg.2421
Escherichia coli F11
MNKKIHSL
A
LLVNL
G
IYGVA
L
P
V
L
A
E
ET
S
D
NAVSH
DDT
I
VVTA
-
A
E
Q
N
L
-
Q
AP
GV
S
---
-------------
T
I
T
A
DEIR
K
N
P
V
A
R
DVS
E
II
R
T
MPGVN
L
---
--
TGNST
S
G
Q
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
K
P
VS
S
R
NSV
RQGW
RGE
RDT
RG
DTSWVPPEM
I
E
R
I
EVLRGP
A
AA
R
YG
N
G
A
A
GG
V
V
NIITK
KG
SGEWH
G
SW
D
A
Y
F
NA
PE
H
KEEGATK
R
TN
FSLTGP
L
-
GD
EFSF
RLYG
NLD
--
KT
Q
A
D
AWD
IN
Q
--
G
HQSAR
AGTYATTLP
AGR
EG
V
I
N
K
DINGV
VR
WDF
AP
LQ
S
LELEA
G
YSRQGN
L
-
Y
AGD
TQ
NTNS
D
---------------
AY
T
RS
--
KY
G
D
-
E
T
NRL
Y
RQ
NY
S
LTWN
GG
WD
N
G
V
T
T
S
NWVQY
EH
-----------
TR
N
SR
IP
E
-
----
G
LA
G
-----
G
TEGKFNEK
A
AQDFVDI
D
L
D
D
V
M
L
H
SEV
N
-
-
-
LPIDF
L
V
--
NQT
----
--
--
--
--
--
LT
L
G
T
EWNQQ
R
M
KDLSS
N
TQA
L
TGT
N
T
---
GGA
I
--
D
G
V
S
A
TD
------------------
R
S
P
Y
SK
AE
I
F
S
L
F
A
EN
N
ME
LTD
S
T
I
V
T
P
GLRFD
H
H
SIVGN
N
WS
PALNISQSL
GD
D
-
---F
T
LKM
G
I
A
RA
----------------
Y
KA
P
S
LY
Q
TN
P
N
--
-
YI
L
Y
S
----
-
K
G
Q
G
CY
A
--
S
AG
GCYLQGND
D
L
KAE
T
SIN
K
EIG
L
EFK
RD
G
-
-
W
L
AG
V
T
W
FR
N
D
YR
NKIE
A
G
Y
V
AV
G
QN
AV
GT
DLYQ
W
D
N
V
P
KA
V
VEG
L
E
G
S
LN---V
P
-
VSE
TVM
W
TN
N
I
T
Y
MLK
S
E
N
K
T
T
----
-
-
-----
GDRL
S
II
PEY
TLN
S
TLSW
QA
RE
D
L
S
M
Q
TTF
T
W
YG
KQQ
P
KKY
-
N
Y
KG
QPAVG
P
ETKEIS
P
-
Y
SIV
G
L
S
AT
W
D
VTKN
V
S
LTGG
VDNLFD
K
R
L
WRAGNA
Q
T
T
G
DLA
GANY
I
A
GA
G
AYT
Y
N
-
E
PG
--
RT
WY
M
SI
NTHF
fig|525281.3.peg.1457
Escherichia coli 83972 (3-725/725)
I
NK
I
F
W
SLT
V
L
---
-
L
V
G
L
N
S
Q
V
S
V
A
KY
S
D
D--DN
D
E
TLVV
E
A
T
A
E
Q
V
L
K
Q
Q
P
GV
S
---
-------------
V
I
T
S
EDIK
K
T
P
P
V
N
DLS
D
II
R
K
MPGVN
L
---
--
TGNS
A
S
G
T
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
V
P
VT
S
R
NSV
R
YS
W
RGE
RDT
RG
DT
N
WVPPE
Q
V
E
R
I
EV
I
RGP
A
AA
R
YG
S
G
A
A
GG
V
V
NIITK
R
P
TNDWH
G
SL
S
L
Y
T
N
Q
PE
S
SEEGATR
R
AN
FSL
S
GP
L
A
GD
ALTT
RLYG
NLN
--
KT
D
A
D
SWD
IN
S
PV
G
TKNA-
---------
AG
H
EG
V
R
N
K
DINGV
V
S
WKL
N
P
Q
Q
I
LDFEV
G
YSRQGN
I
-
Y
AGD
TQ
NSSS
S
---------------
AV
T
ES
L
A
KS
G
K
-
E
T
NRL
Y
RQ
NY
G
I
T
H
N
GI
WD
W
G
-
Q
S
R
FGVYY
E
K
-----------
T
N
N
T
R
MN
E
-
----
G
LS
G
-----
G
GEGRI--L
A
GEKFTTN
R
L
S
S
W
RT
S
GEL
N
-
-
-
IPLNV
M
V
--
D
QT
----
--
--
--
--
--
LT
V
G
A
EWN
R
D
K
L
DDPSS
T
SLT
V
NDR
D
I
---
SG-
I
--
S
G
-
S
A
AD
------------------
R
S
S
K
NH
SQ
I
S
A
L
Y
I
ED
N
IE
PVP
G
T
N
I
I
P
GLRFD
YL
SDSGG
N
F
S
PSLNLSQEL
GD
Y
-
---F
K
VKA
G
V
A
RT
----------------
F
KA
P
N
LY
Q
S
S
E
G
--
-
Y
L
L
Y
S
----
-
K
G
N
G
CP
KDI
T
S
G
GCYLIGNK
D
L
D
P
E
I
S
V
N
K
EIG
L
EF
T
WE
D
-
-
Y
H
AS
V
T
Y
FR
N
D
YQ
NKI
V
A
G
D
N
VI
G
Q
T
AS
G
AYILK
W
Q
N
G
GKA
L
V
D
G
I
E
A
S
MS---F
P
L
V
K
E
RLN
W
NT
N
A
T
W
M
IT
S
E
Q
K
D
T
----
-
-
-----
G
N
P
L
S
VI
P
K
Y
TIN
N
SLNW
TI
TQ
A
F
S
A
S
FNW
T
L
YG
RQK
P
RTH
AE
T
R
S
EDTGG
L
SGKELG
A
-
Y
SLV
G
T
N
FN
Y
D
I
N
KNL
R
LNVG
V
S
N
I
L
N
K
Q
I
F
R
SSE
-
-
-
-
-
---
-
-----
--
G
ANT
Y
N
-
E
PG
--
R
A
YY
A
GV
TAS
F
fig|655817.3.peg.1278
Escherichia coli ABU 83972 (3-725/725)
I
NK
I
F
W
SLT
V
L
---
-
L
V
G
L
N
S
Q
V
S
V
A
KY
S
D
D--DN
D
E
TLVV
E
A
T
A
E
Q
V
L
K
Q
Q
P
GV
S
---
-------------
V
I
T
S
EDIK
K
T
P
P
V
N
DLS
D
II
R
K
MPGVN
L
---
--
TGNS
A
S
G
T
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
V
P
VT
S
R
NSV
R
YS
W
RGE
RDT
RG
DT
N
WVPPE
Q
V
E
R
I
EV
I
RGP
A
AA
R
YG
S
G
A
A
GG
V
V
NIITK
R
P
TNDWH
G
SL
S
L
Y
T
N
Q
PE
S
SEEGATR
R
AN
FSL
S
GP
L
A
GD
ALTT
RLYG
NLN
--
KT
D
A
D
SWD
IN
S
PV
G
TKNA-
---------
AG
H
EG
V
R
N
K
DINGV
V
S
WKL
N
P
Q
Q
I
LDFEV
G
YSRQGN
I
-
Y
AGD
TQ
NSSS
S
---------------
AV
T
ES
L
A
KS
G
K
-
E
T
NRL
Y
RQ
NY
G
I
T
H
N
GI
WD
W
G
-
Q
S
R
FGVYY
E
K
-----------
T
N
N
T
R
MN
E
-
----
G
LS
G
-----
G
GEGRI--L
A
GEKFTTN
R
L
S
S
W
RT
S
GEL
N
-
-
-
IPLNV
M
V
--
D
QT
----
--
--
--
--
--
LT
V
G
A
EWN
R
D
K
L
DDPSS
T
SLT
V
NDR
D
I
---
SG-
I
--
S
G
-
S
A
AD
------------------
R
S
S
K
NH
SQ
I
S
A
L
Y
I
ED
N
IE
PVP
G
T
N
I
I
P
GLRFD
YL
SDSGG
N
F
S
PSLNLSQEL
GD
Y
-
---F
K
VKA
G
V
A
RT
----------------
F
KA
P
N
LY
Q
S
S
E
G
--
-
Y
L
L
Y
S
----
-
K
G
N
G
CP
KDI
T
S
G
GCYLIGNK
D
L
D
P
E
I
S
V
N
K
EIG
L
EF
T
WE
D
-
-
Y
H
AS
V
T
Y
FR
N
D
YQ
NKI
V
A
G
D
N
VI
G
Q
T
AS
G
AYILK
W
Q
N
G
GKA
L
V
D
G
I
E
A
S
MS---F
P
L
V
K
E
RLN
W
NT
N
A
T
W
M
IT
S
E
Q
K
D
T
----
-
-
-----
G
N
P
L
S
VI
P
K
Y
TIN
N
SLNW
TI
TQ
A
F
S
A
S
FNW
T
L
YG
RQK
P
RTH
AE
T
R
S
EDTGG
L
SGKELG
A
-
Y
SLV
G
T
N
FN
Y
D
I
N
KNL
R
LNVG
V
S
N
I
L
N
K
Q
I
F
R
SSE
-
-
-
-
-
---
-
-----
--
G
ANT
Y
N
-
E
PG
--
R
A
YY
A
GV
TAS
F
fig|199310.1.peg.1207
Escherichia coli CFT073 (3-725/725)
I
NK
I
L
W
SLT
V
L
---
-
L
V
G
L
N
S
Q
V
S
V
A
KY
S
D
D--DN
D
E
TLVV
E
A
T
A
E
Q
V
L
K
Q
Q
P
GV
S
---
-------------
V
I
T
S
EDIK
K
T
P
P
V
N
DLS
D
II
R
K
MPGVN
L
---
--
TGNS
A
S
G
T
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
V
P
VT
S
R
NSV
R
YS
W
RGE
RDT
RG
DT
N
WVPPE
Q
V
E
R
I
EV
I
RGP
A
AA
R
YG
S
G
A
A
GG
V
V
NIITK
R
P
TNDWH
G
SL
S
L
Y
T
N
Q
PE
S
SEEGATR
R
AN
FSL
S
GP
L
A
GD
ALTT
RLYG
NLN
--
KT
D
A
D
SWD
IN
S
PV
G
TKNA-
---------
AG
H
EG
V
R
N
K
DINGV
V
S
WKL
N
P
Q
Q
I
LDFEV
G
YSRQGN
I
-
Y
AGD
TQ
NSSS
S
---------------
AV
T
ES
L
A
KS
G
K
-
E
T
NRL
Y
RQ
NY
G
I
T
H
N
GI
WD
W
G
-
Q
S
R
FGVYY
E
K
-----------
T
N
N
T
R
MN
E
-
----
G
LS
G
-----
G
GEGRI--L
A
GEKFTTN
R
L
S
S
W
RT
S
GEL
N
-
-
-
IPLNV
M
V
--
D
QT
----
--
--
--
--
--
LT
V
G
A
EWN
R
D
K
L
DDPSS
T
SLT
V
NDR
D
I
---
SG-
I
--
S
G
-
S
A
AD
------------------
R
S
S
K
NH
SQ
I
S
A
L
Y
I
ED
N
IE
PVP
G
T
N
I
I
P
GLRFD
YL
SDSGG
N
F
S
PSLNLSQEL
GD
Y
-
---F
K
VKA
G
V
A
RT
----------------
F
KA
P
N
LY
Q
S
S
E
G
--
-
Y
L
L
Y
S
----
-
K
G
N
G
CP
KDI
T
S
G
GCYLIGNK
D
L
D
P
E
I
S
V
N
K
EIG
L
EF
T
WE
D
-
-
Y
H
AS
V
T
Y
FR
N
D
YQ
NKI
V
A
G
D
N
VI
G
Q
T
AS
G
AYILK
W
Q
N
G
GKA
L
V
D
G
I
E
A
S
MS---F
P
L
V
K
E
RLN
W
NT
N
A
T
W
M
IT
S
E
Q
K
D
T
----
-
-
-----
G
N
P
L
S
VI
P
K
Y
TIN
N
SLNW
TI
TQ
A
F
S
A
S
FNW
T
L
YG
RQK
P
RTH
AE
T
R
S
EDTGG
L
SGKELG
A
-
Y
SLV
G
T
N
FN
Y
D
I
N
KNL
R
LNVG
V
S
N
I
L
N
K
Q
I
F
R
SSE
-
-
-
-
-
---
-
-----
--
G
ANT
Y
N
-
E
PG
--
R
A
YY
A
GV
TAS
F
fig|199310.4.peg.1186
Escherichia coli CFT073 (3-725/725)
I
NK
I
L
W
SLT
V
L
---
-
L
V
G
L
N
S
Q
V
S
V
A
KY
S
D
D--DN
D
E
TLVV
E
A
T
A
E
Q
V
L
K
Q
Q
P
GV
S
---
-------------
V
I
T
S
EDIK
K
T
P
P
V
N
DLS
D
II
R
K
MPGVN
L
---
--
TGNS
A
S
G
T
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
V
P
VT
S
R
NSV
R
YS
W
RGE
RDT
RG
DT
N
WVPPE
Q
V
E
R
I
EV
I
RGP
A
AA
R
YG
S
G
A
A
GG
V
V
NIITK
R
P
TNDWH
G
SL
S
L
Y
T
N
Q
PE
S
SEEGATR
R
AN
FSL
S
GP
L
A
GD
ALTT
RLYG
NLN
--
KT
D
A
D
SWD
IN
S
PV
G
TKNA-
---------
AG
H
EG
V
R
N
K
DINGV
V
S
WKL
N
P
Q
Q
I
LDFEV
G
YSRQGN
I
-
Y
AGD
TQ
NSSS
S
---------------
AV
T
ES
L
A
KS
G
K
-
E
T
NRL
Y
RQ
NY
G
I
T
H
N
GI
WD
W
G
-
Q
S
R
FGVYY
E
K
-----------
T
N
N
T
R
MN
E
-
----
G
LS
G
-----
G
GEGRI--L
A
GEKFTTN
R
L
S
S
W
RT
S
GEL
N
-
-
-
IPLNV
M
V
--
D
QT
----
--
--
--
--
--
LT
V
G
A
EWN
R
D
K
L
DDPSS
T
SLT
V
NDR
D
I
---
SG-
I
--
S
G
-
S
A
AD
------------------
R
S
S
K
NH
SQ
I
S
A
L
Y
I
ED
N
IE
PVP
G
T
N
I
I
P
GLRFD
YL
SDSGG
N
F
S
PSLNLSQEL
GD
Y
-
---F
K
VKA
G
V
A
RT
----------------
F
KA
P
N
LY
Q
S
S
E
G
--
-
Y
L
L
Y
S
----
-
K
G
N
G
CP
KDI
T
S
G
GCYLIGNK
D
L
D
P
E
I
S
V
N
K
EIG
L
EF
T
WE
D
-
-
Y
H
AS
V
T
Y
FR
N
D
YQ
NKI
V
A
G
D
N
VI
G
Q
T
AS
G
AYILK
W
Q
N
G
GKA
L
V
D
G
I
E
A
S
MS---F
P
L
V
K
E
RLN
W
NT
N
A
T
W
M
IT
S
E
Q
K
D
T
----
-
-
-----
G
N
P
L
S
VI
P
K
Y
TIN
N
SLNW
TI
TQ
A
F
S
A
S
FNW
T
L
YG
RQK
P
RTH
AE
T
R
S
EDTGG
L
SGKELG
A
-
Y
SLV
G
T
N
FN
Y
D
I
N
KNL
R
LNVG
V
S
N
I
L
N
K
Q
I
F
R
SSE
-
-
-
-
-
---
-
-----
--
G
ANT
Y
N
-
E
PG
--
R
A
YY
A
GV
TAS
F
fig|714962.3.peg.1126
Escherichia coli IHE3034 (3-725/725)
I
NK
I
L
W
SLT
V
L
---
-
L
V
G
L
N
S
Q
I
S
V
A
KY
S
D
D--DN
D
E
TLVV
E
A
T
A
E
Q
V
L
K
Q
Q
P
GV
S
---
-------------
V
I
T
S
EDIK
K
T
P
P
V
N
DLS
D
II
R
K
MPGVN
L
---
--
TGNS
A
S
G
T
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
V
P
VT
S
R
NSV
R
YS
W
RGE
RDT
RG
DT
N
WVPPE
Q
V
E
R
I
EV
I
RGP
A
AA
R
YG
S
G
A
A
GG
V
V
NIITK
R
P
TNDWH
G
SL
S
L
Y
T
N
Q
PE
S
SEEGATR
R
AN
FSL
S
GP
L
A
GD
ALTT
RLYG
NLN
--
KT
D
A
D
SWD
IN
S
PV
G
TKNA-
---------
AG
H
EG
V
R
N
K
DINGV
I
S
WKL
N
P
Q
Q
I
LDFEA
G
YSRQGN
I
-
Y
AGD
TQ
NSSS
S
---------------
AV
T
ES
L
A
KS
G
K
-
E
T
NRL
Y
RQ
NY
G
I
T
H
N
GI
WD
W
G
-
Q
S
R
FGVYY
E
K
-----------
T
N
N
T
R
MN
E
-
----
G
LS
G
-----
G
GEGRI--L
A
GEKFTTN
R
L
S
S
W
RT
S
GEL
N
-
-
-
IPLNV
M
V
--
D
QT
----
--
--
--
--
--
LT
V
G
A
EWN
R
D
K
L
DDPSS
T
SLT
V
NDR
D
I
---
SG-
I
--
S
G
-
S
A
AD
------------------
R
S
S
K
NH
SQ
I
S
A
L
Y
I
ED
N
IE
PVP
G
T
N
I
I
P
GLRFD
YL
SDSGG
N
F
S
PSLNLSQEL
GD
Y
-
---F
K
VKA
G
V
A
RT
----------------
F
KA
P
N
LY
Q
S
S
E
G
--
-
Y
L
L
Y
S
----
-
K
G
N
G
CP
KDI
T
S
G
GCYLIGNK
D
L
D
P
E
I
S
V
N
K
EIG
L
EF
T
WE
D
-
-
Y
H
AS
V
T
Y
FR
N
D
YQ
NKI
V
A
G
D
N
VI
G
Q
T
AS
G
AYILK
W
Q
N
G
GKA
L
V
D
G
I
E
A
S
MS---F
P
L
V
KD
RLN
W
NT
N
A
T
W
M
IT
S
E
Q
K
D
T
----
-
-
-----
G
N
P
L
S
VI
P
K
Y
TIN
N
SLNW
TI
TQ
A
F
S
A
S
VNW
T
L
YG
RQK
P
RTH
AE
T
R
S
EDTGG
L
SGKELG
A
-
Y
SLV
G
T
N
FN
Y
D
I
N
KNL
R
LNVG
V
S
N
I
L
N
K
Q
I
F
R
SSE
-
-
-
-
-
---
-
-----
--
G
ANT
Y
N
-
E
PG
--
R
A
YY
A
GV
TAS
F
fig|753642.3.peg.546
Escherichia coli NC101 (3-725/725)
I
NK
I
L
W
SLT
V
L
---
-
L
V
G
L
N
S
Q
I
S
V
A
KY
S
D
D--DN
D
E
TLVV
E
A
T
A
E
Q
V
L
K
Q
Q
P
GV
S
---
-------------
V
I
T
S
EDIK
K
T
P
P
V
N
DLS
D
II
R
K
MPGVN
L
---
--
TGNS
A
S
G
T
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
V
P
VT
S
R
NSV
R
YS
W
RGE
RDT
RG
DT
N
WVPPE
Q
V
E
R
I
EV
I
RGP
A
AA
R
YG
S
G
A
A
GG
V
V
NIITK
R
P
TNDWH
G
SL
S
L
Y
T
N
Q
PE
S
SEEGATR
R
AN
FSL
S
GP
L
A
GD
ALTT
RLYG
NLN
--
KT
D
A
D
SWD
IN
S
PV
G
TKNA-
---------
AG
H
EG
V
R
N
K
DINGV
I
S
WKL
N
P
Q
Q
I
LDFEA
G
YSRQGN
I
-
Y
AGD
TQ
NSSS
S
---------------
AV
T
ES
L
A
KS
G
K
-
E
T
NRL
Y
RQ
NY
G
I
T
H
N
GI
WD
W
G
-
Q
S
R
FGVYY
E
K
-----------
T
N
N
T
R
MN
E
-
----
G
LS
G
-----
G
GEGRI--L
A
GEKFTTN
R
L
S
S
W
RT
S
GEL
N
-
-
-
IPLNV
M
V
--
D
QT
----
--
--
--
--
--
LT
V
G
A
EWN
R
D
K
L
DDPSS
T
SLT
V
NDR
D
I
---
SG-
I
--
S
G
-
S
A
AD
------------------
R
S
S
K
NH
SQ
I
S
A
L
Y
I
ED
N
IE
PVP
G
T
N
I
I
P
GLRFD
YL
SDSGG
N
F
S
PSLNLSQEL
GD
Y
-
---F
K
VKA
G
V
A
RT
----------------
F
KA
P
N
LY
Q
S
S
E
G
--
-
Y
L
L
Y
S
----
-
K
G
N
G
CP
KDI
T
S
G
GCYLIGNK
D
L
D
P
E
I
S
V
N
K
EIG
L
EF
T
WE
D
-
-
Y
H
AS
V
T
Y
FR
N
D
YQ
NKI
V
A
G
D
N
VI
G
Q
T
AS
G
AYILK
W
Q
N
G
GKA
L
V
D
G
I
E
A
S
MS---F
P
L
V
KD
RLN
W
NT
N
A
T
W
M
IT
S
E
Q
K
D
T
----
-
-
-----
G
N
P
L
S
VI
P
K
Y
TIN
N
SLNW
TI
TQ
A
F
S
A
S
VNW
T
L
YG
RQK
P
RTH
AE
T
R
S
EDTGG
L
SGKELG
A
-
Y
SLV
G
T
N
FN
Y
D
I
N
KNL
R
LNVG
V
S
N
I
L
N
K
Q
I
F
R
SSE
-
-
-
-
-
---
-
-----
--
G
ANT
Y
N
-
E
PG
--
R
A
YY
A
GV
TAS
F
fig|362663.8.peg.300
Escherichia coli 536 (3-725/725)
I
NK
I
L
W
SLT
V
L
---
-
L
V
G
L
N
S
Q
V
S
V
A
KY
S
D
D--DN
D
E
TLVV
E
A
T
A
E
Q
V
L
K
Q
Q
P
GV
S
---
-------------
V
I
T
S
EDIK
K
T
P
P
V
N
DLS
D
II
R
K
MPGVN
L
---
--
TGNS
A
S
G
T
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
V
P
VT
S
R
NSV
R
YS
W
RGE
RDT
RG
DT
N
WVPPE
Q
V
E
R
I
EV
I
RGP
A
AA
R
YG
S
G
A
A
GG
V
V
NIITK
R
P
TNDWH
G
SL
S
L
Y
T
N
Q
PE
S
SEEGATR
R
AN
FSL
S
GP
L
A
GD
ALTT
RLYG
NLN
--
KT
D
A
D
SWD
IN
S
PV
G
TKNA-
---------
AG
H
EG
V
R
N
K
DINGV
I
S
WKL
N
P
Q
Q
I
LDFEA
G
YSRQGN
I
-
Y
AGD
TQ
NSSS
S
---------------
AV
T
ES
L
A
KS
G
K
-
E
T
NRL
Y
RQ
NY
G
I
T
H
N
GI
WD
W
G
-
Q
S
R
FGIYY
E
K
-----------
T
N
N
T
R
MN
E
-
----
G
LS
G
-----
G
GEGRI--L
A
GEKFTTN
R
L
S
S
W
RT
S
GEL
N
-
-
-
IPLNV
M
V
--
D
QT
----
--
--
--
--
--
LT
V
G
A
EWN
R
D
K
L
DDPSS
T
SLT
V
NDR
D
I
---
SG-
I
--
S
G
-
S
A
AD
------------------
R
S
S
K
NH
SQ
I
S
A
L
Y
I
ED
N
IE
PVP
G
T
N
I
I
P
GLRFD
YL
SDSGG
N
F
S
PSLNLSQEL
GD
Y
-
---F
K
VKA
G
V
A
RT
----------------
F
KA
P
N
LY
Q
S
S
E
G
--
-
Y
L
L
Y
S
----
-
K
G
N
G
CP
KDI
T
S
G
GCYLIGNK
D
L
D
P
E
I
S
V
N
K
EIG
L
EF
T
WE
D
-
-
Y
H
AS
V
T
Y
FR
N
D
YQ
NKI
V
A
G
D
N
VI
G
Q
T
AS
G
AYILK
W
Q
N
G
GKA
L
V
D
G
I
E
A
S
MS---F
P
L
V
KD
RLN
W
NT
N
A
T
W
M
IT
S
E
Q
K
D
T
----
-
-
-----
G
N
P
L
S
VI
P
K
Y
TIN
N
SLNW
TI
TQ
A
F
S
A
N
VNW
T
L
YG
RQK
P
RTH
AE
T
R
S
EDTGG
L
SGKELG
A
-
Y
SLV
G
T
N
FN
Y
D
I
N
KNL
R
LNVG
V
S
N
I
L
N
K
Q
I
F
R
SSE
-
-
-
-
-
---
-
-----
--
G
ANT
Y
N
-
E
PG
--
R
A
YY
A
GV
TAS
F
fig|362663.9.peg.299
Escherichia coli 536 (3-725/725)
I
NK
I
L
W
SLT
V
L
---
-
L
V
G
L
N
S
Q
V
S
V
A
KY
S
D
D--DN
D
E
TLVV
E
A
T
A
E
Q
V
L
K
Q
Q
P
GV
S
---
-------------
V
I
T
S
EDIK
K
T
P
P
V
N
DLS
D
II
R
K
MPGVN
L
---
--
TGNS
A
S
G
T
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
V
P
VT
S
R
NSV
R
YS
W
RGE
RDT
RG
DT
N
WVPPE
Q
V
E
R
I
EV
I
RGP
A
AA
R
YG
S
G
A
A
GG
V
V
NIITK
R
P
TNDWH
G
SL
S
L
Y
T
N
Q
PE
S
SEEGATR
R
AN
FSL
S
GP
L
A
GD
ALTT
RLYG
NLN
--
KT
D
A
D
SWD
IN
S
PV
G
TKNA-
---------
AG
H
EG
V
R
N
K
DINGV
I
S
WKL
N
P
Q
Q
I
LDFEA
G
YSRQGN
I
-
Y
AGD
TQ
NSSS
S
---------------
AV
T
ES
L
A
KS
G
K
-
E
T
NRL
Y
RQ
NY
G
I
T
H
N
GI
WD
W
G
-
Q
S
R
FGIYY
E
K
-----------
T
N
N
T
R
MN
E
-
----
G
LS
G
-----
G
GEGRI--L
A
GEKFTTN
R
L
S
S
W
RT
S
GEL
N
-
-
-
IPLNV
M
V
--
D
QT
----
--
--
--
--
--
LT
V
G
A
EWN
R
D
K
L
DDPSS
T
SLT
V
NDR
D
I
---
SG-
I
--
S
G
-
S
A
AD
------------------
R
S
S
K
NH
SQ
I
S
A
L
Y
I
ED
N
IE
PVP
G
T
N
I
I
P
GLRFD
YL
SDSGG
N
F
S
PSLNLSQEL
GD
Y
-
---F
K
VKA
G
V
A
RT
----------------
F
KA
P
N
LY
Q
S
S
E
G
--
-
Y
L
L
Y
S
----
-
K
G
N
G
CP
KDI
T
S
G
GCYLIGNK
D
L
D
P
E
I
S
V
N
K
EIG
L
EF
T
WE
D
-
-
Y
H
AS
V
T
Y
FR
N
D
YQ
NKI
V
A
G
D
N
VI
G
Q
T
AS
G
AYILK
W
Q
N
G
GKA
L
V
D
G
I
E
A
S
MS---F
P
L
V
KD
RLN
W
NT
N
A
T
W
M
IT
S
E
Q
K
D
T
----
-
-
-----
G
N
P
L
S
VI
P
K
Y
TIN
N
SLNW
TI
TQ
A
F
S
A
N
VNW
T
L
YG
RQK
P
RTH
AE
T
R
S
EDTGG
L
SGKELG
A
-
Y
SLV
G
T
N
FN
Y
D
I
N
KNL
R
LNVG
V
S
N
I
L
N
K
Q
I
F
R
SSE
-
-
-
-
-
---
-
-----
--
G
ANT
Y
N
-
E
PG
--
R
A
YY
A
GV
TAS
F
fig|340197.3.peg.1359
Escherichia coli F11 (3-725/725)
I
NK
I
L
W
SLT
V
L
---
-
L
V
G
L
N
S
Q
V
S
V
A
KY
S
D
D--DN
D
E
TLVV
E
A
T
A
E
Q
V
L
K
Q
Q
P
GV
S
---
-------------
V
I
T
S
EDIK
K
T
P
P
V
N
DLS
D
II
R
K
MPGVN
L
---
--
TGNS
A
S
G
T
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
V
P
VT
S
R
NSV
R
YS
W
RGE
RDT
RG
DT
N
WVPPE
Q
V
E
R
I
EV
I
RGP
A
AA
R
YG
S
G
A
A
GG
V
V
NIITK
R
P
TNDWH
G
SL
S
L
Y
T
N
Q
PE
S
SEEGATR
R
AN
FSL
S
GP
L
A
GD
ALTT
RLYG
NLN
--
KT
D
A
D
SWD
IN
S
PV
G
TKNA-
---------
AG
H
EG
V
R
N
K
DINGV
I
S
WKL
N
P
Q
Q
I
LDFEA
G
YSRQGN
I
-
Y
AGD
TQ
NSSS
S
---------------
AV
T
ES
L
A
KS
G
K
-
E
T
NRL
Y
RQ
NY
G
I
T
H
N
GI
WD
W
G
-
Q
S
R
FGIYY
E
K
-----------
T
N
N
T
R
MN
E
-
----
G
LS
G
-----
G
GEGRI--L
A
GEKFTTN
R
L
S
S
W
RT
S
GEL
N
-
-
-
IPLNV
M
V
--
D
QT
----
--
--
--
--
--
LT
V
G
A
EWN
R
D
K
L
DDPSS
T
SLT
V
NDR
D
I
---
SG-
I
--
S
G
-
S
A
AD
------------------
R
S
S
K
NH
SQ
I
S
A
L
Y
I
ED
N
IE
PVP
G
T
N
I
I
P
GLRFD
YL
SDSGG
N
F
S
PSLNLSQEL
GD
Y
-
---F
K
VKA
G
V
A
RT
----------------
F
KA
P
N
LY
Q
S
S
E
G
--
-
Y
L
L
Y
S
----
-
K
G
N
G
CP
KDI
T
S
G
GCYLIGNK
D
L
D
P
E
I
S
V
N
K
EIG
L
EF
T
WE
D
-
-
Y
H
AS
V
T
Y
FR
N
D
YQ
NKI
V
A
G
D
N
VI
G
Q
T
AS
G
AYILK
W
Q
N
G
GKA
L
V
D
G
I
E
A
S
MS---F
P
L
V
KD
RLN
W
NT
N
A
T
W
M
IT
S
E
Q
K
D
T
----
-
-
-----
G
N
P
L
S
VI
P
K
Y
TIN
N
SLNW
TI
TQ
A
F
S
A
N
VNW
T
L
YG
RQK
P
RTH
AE
T
R
S
EDTGG
L
SGKELG
A
-
Y
SLV
G
T
N
FN
Y
D
I
N
KNL
R
LNVG
V
S
N
I
L
N
K
Q
I
F
R
SSE
-
-
-
-
-
---
-
-----
--
G
ANT
Y
N
-
E
PG
--
R
A
YY
A
GV
TAS
F
fig|340197.5.peg.1435
Escherichia coli F11 (3-725/725)
I
NK
I
L
W
SLT
V
L
---
-
L
V
G
L
N
S
Q
V
S
V
A
KY
S
D
D--DN
D
E
TLVV
E
A
T
A
E
Q
V
L
K
Q
Q
P
GV
S
---
-------------
V
I
T
S
EDIK
K
T
P
P
V
N
DLS
D
II
R
K
MPGVN
L
---
--
TGNS
A
S
G
T
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
V
P
VT
S
R
NSV
R
YS
W
RGE
RDT
RG
DT
N
WVPPE
Q
V
E
R
I
EV
I
RGP
A
AA
R
YG
S
G
A
A
GG
V
V
NIITK
R
P
TNDWH
G
SL
S
L
Y
T
N
Q
PE
S
SEEGATR
R
AN
FSL
S
GP
L
A
GD
ALTT
RLYG
NLN
--
KT
D
A
D
SWD
IN
S
PV
G
TKNA-
---------
AG
H
EG
V
R
N
K
DINGV
I
S
WKL
N
P
Q
Q
I
LDFEA
G
YSRQGN
I
-
Y
AGD
TQ
NSSS
S
---------------
AV
T
ES
L
A
KS
G
K
-
E
T
NRL
Y
RQ
NY
G
I
T
H
N
GI
WD
W
G
-
Q
S
R
FGIYY
E
K
-----------
T
N
N
T
R
MN
E
-
----
G
LS
G
-----
G
GEGRI--L
A
GEKFTTN
R
L
S
S
W
RT
S
GEL
N
-
-
-
IPLNV
M
V
--
D
QT
----
--
--
--
--
--
LT
V
G
A
EWN
R
D
K
L
DDPSS
T
SLT
V
NDR
D
I
---
SG-
I
--
S
G
-
S
A
AD
------------------
R
S
S
K
NH
SQ
I
S
A
L
Y
I
ED
N
IE
PVP
G
T
N
I
I
P
GLRFD
YL
SDSGG
N
F
S
PSLNLSQEL
GD
Y
-
---F
K
VKA
G
V
A
RT
----------------
F
KA
P
N
LY
Q
S
S
E
G
--
-
Y
L
L
Y
S
----
-
K
G
N
G
CP
KDI
T
S
G
GCYLIGNK
D
L
D
P
E
I
S
V
N
K
EIG
L
EF
T
WE
D
-
-
Y
H
AS
V
T
Y
FR
N
D
YQ
NKI
V
A
G
D
N
VI
G
Q
T
AS
G
AYILK
W
Q
N
G
GKA
L
V
D
G
I
E
A
S
MS---F
P
L
V
KD
RLN
W
NT
N
A
T
W
M
IT
S
E
Q
K
D
T
----
-
-
-----
G
N
P
L
S
VI
P
K
Y
TIN
N
SLNW
TI
TQ
A
F
S
A
N
VNW
T
L
YG
RQK
P
RTH
AE
T
R
S
EDTGG
L
SGKELG
A
-
Y
SLV
G
T
N
FN
Y
D
I
N
KNL
R
LNVG
V
S
N
I
L
N
K
Q
I
F
R
SSE
-
-
-
-
-
---
-
-----
--
G
ANT
Y
N
-
E
PG
--
R
A
YY
A
GV
TAS
F
fig|749550.3.peg.163
Escherichia coli MS 200-1 (3-725/725)
I
NK
I
L
W
SLT
V
L
---
-
L
V
G
L
N
S
Q
V
S
V
A
KY
S
D
D--DN
D
E
TLVV
E
A
T
A
E
Q
V
L
K
Q
Q
P
GV
S
---
-------------
V
I
T
S
EDIK
K
T
P
P
V
N
DLS
D
II
R
K
MPGVN
L
---
--
TGNS
A
S
G
T
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
V
P
VT
S
R
NSV
R
YS
W
RGE
RDT
RG
DT
N
WVPPE
Q
V
E
R
I
EV
I
RGP
A
AA
R
YG
S
G
A
A
GG
V
V
NIITK
R
P
TNDWH
G
SL
S
L
Y
T
N
Q
PE
S
SEEGATR
R
AN
FSL
S
GP
L
A
GD
ALTT
RLYG
NLN
--
KT
D
A
D
SWD
IN
S
PV
G
TKNA-
---------
AG
H
EG
V
R
N
K
DINGV
I
S
WKL
N
P
Q
Q
I
LDFEA
G
YSRQGN
I
-
Y
AGD
TQ
NSSS
S
---------------
AV
T
ES
L
A
KS
G
K
-
E
T
NRL
Y
RQ
NY
G
I
T
H
N
GI
WD
W
G
-
Q
S
R
FGIYY
E
K
-----------
T
N
N
T
R
MN
E
-
----
G
LS
G
-----
G
GEGRI--L
A
GEKFTTN
R
L
S
S
W
RT
S
GEL
N
-
-
-
IPLNV
M
V
--
D
QT
----
--
--
--
--
--
LT
V
G
A
EWN
R
D
K
L
DDPSS
T
SLT
V
NDR
D
I
---
SG-
I
--
S
G
-
S
A
AD
------------------
R
S
S
K
NH
SQ
I
S
A
L
Y
I
ED
N
IE
PVP
G
T
N
I
I
P
GLRFD
YL
SDSGG
N
F
S
PSLNLSQEL
GD
Y
-
---F
K
VKA
G
V
A
RT
----------------
F
KA
P
N
LY
Q
S
S
E
G
--
-
Y
L
L
Y
S
----
-
K
G
N
G
CP
KDI
T
S
G
GCYLIGNK
D
L
D
P
E
I
S
V
N
K
EIG
L
EF
T
WE
D
-
-
Y
H
AS
V
T
Y
FR
N
D
YQ
NKI
V
A
G
D
N
VI
G
Q
T
AS
G
AYILK
W
Q
N
G
GKA
L
V
D
G
I
E
A
S
MS---F
P
L
V
KD
RLN
W
NT
N
A
T
W
M
IT
S
E
Q
K
D
T
----
-
-
-----
G
N
P
L
S
VI
P
K
Y
TIN
N
SLNW
TI
TQ
A
F
S
A
N
VNW
T
L
YG
RQK
P
RTH
AE
T
R
S
EDTGG
L
SGKELG
A
-
Y
SLV
G
T
N
FN
Y
D
I
N
KNL
R
LNVG
V
S
N
I
L
N
K
Q
I
F
R
SSE
-
-
-
-
-
---
-
-----
--
G
ANT
Y
N
-
E
PG
--
R
A
YY
A
GV
TAS
F
fig|405955.13.peg.5148
Escherichia coli APEC O1 (3-725/725)
I
NK
I
L
W
SLT
V
L
---
-
L
V
G
L
N
S
Q
V
S
V
A
KS
S
D
D--DN
D
E
TLVV
E
A
T
A
E
Q
V
L
K
Q
Q
P
GV
S
---
-------------
V
I
T
S
EDIK
K
T
P
P
V
N
DLS
D
II
R
K
MPGVN
L
---
--
TGNS
A
S
G
T
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
V
P
VT
S
R
NSV
R
YS
W
RGE
RDT
RG
DT
N
WVPPE
Q
V
E
R
I
EV
I
RGP
A
AA
R
YG
S
G
A
A
GG
V
V
NIITK
R
P
TNDWH
G
SL
S
L
Y
T
N
Q
PE
S
SDEGATR
R
AN
FSL
S
GP
L
A
G
N
ALTT
RLYG
NLN
--
KT
D
A
D
SWD
IN
S
PV
G
TKNA-
---------
AG
H
EG
V
R
N
K
DINGV
V
S
WKL
N
P
Q
Q
I
LDFEA
G
YSRQGN
I
-
Y
AGD
TQ
NSSS
S
---------------
AV
T
ES
L
A
KS
G
K
-
E
T
NRL
Y
RQ
NY
G
I
T
H
N
GI
WD
W
G
-
Q
S
R
FGVYY
E
K
-----------
T
N
N
T
R
MN
E
-
----
G
LS
G
-----
G
GEGRI--L
A
GEKFTTN
R
L
S
S
W
RT
S
GEL
N
-
-
-
IPLNV
M
V
--
D
QT
----
--
--
--
--
--
LT
V
G
A
EWN
R
D
K
L
DDPSS
T
SLT
V
NDS
D
I
---
SG-
I
--
S
G
-
S
A
AD
------------------
R
S
S
K
NH
SQ
I
S
A
L
Y
I
ED
N
IE
PVP
G
T
N
I
I
P
GLRFD
YL
SDSGG
N
F
S
PSLNLSQEL
GD
Y
-
---F
K
VKA
G
V
A
RT
----------------
F
KA
P
N
LY
Q
S
S
E
G
--
-
Y
L
L
Y
S
----
-
K
G
N
G
CP
KDI
T
S
G
GCYLIGNK
D
L
D
P
E
I
S
V
N
K
EIG
L
EF
T
WE
D
-
-
Y
H
AS
V
T
Y
FR
N
D
YQ
NKI
V
A
G
D
N
VI
G
Q
T
AS
G
AYILK
W
Q
N
G
GKA
L
V
D
G
I
E
A
S
MS---F
P
L
V
KD
RLN
W
NT
N
A
T
W
M
IT
S
E
Q
K
D
T
----
-
-
-----
G
N
P
L
S
VI
P
K
Y
TIN
N
SLNW
TI
TQ
A
F
S
A
S
VNW
T
L
YG
RQK
P
RTH
AE
T
R
S
EDTGG
L
SGKELG
A
-
Y
SLV
G
T
N
FN
Y
D
I
N
KNL
R
LNVG
V
S
N
I
L
N
K
Q
I
F
R
SSE
-
-
-
-
-
---
-
-----
--
G
ANT
Y
N
-
E
PG
--
R
A
YY
A
GV
TAS
F
fig|405955.9.peg.4312
Escherichia coli APEC O1 (3-725/725)
I
NK
I
L
W
SLT
V
L
---
-
L
V
G
L
N
S
Q
V
S
V
A
KS
S
D
D--DN
D
E
TLVV
E
A
T
A
E
Q
V
L
K
Q
Q
P
GV
S
---
-------------
V
I
T
S
EDIK
K
T
P
P
V
N
DLS
D
II
R
K
MPGVN
L
---
--
TGNS
A
S
G
T
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
V
P
VT
S
R
NSV
R
YS
W
RGE
RDT
RG
DT
N
WVPPE
Q
V
E
R
I
EV
I
RGP
A
AA
R
YG
S
G
A
A
GG
V
V
NIITK
R
P
TNDWH
G
SL
S
L
Y
T
N
Q
PE
S
SDEGATR
R
AN
FSL
S
GP
L
A
G
N
ALTT
RLYG
NLN
--
KT
D
A
D
SWD
IN
S
PV
G
TKNA-
---------
AG
H
EG
V
R
N
K
DINGV
V
S
WKL
N
P
Q
Q
I
LDFEA
G
YSRQGN
I
-
Y
AGD
TQ
NSSS
S
---------------
AV
T
ES
L
A
KS
G
K
-
E
T
NRL
Y
RQ
NY
G
I
T
H
N
GI
WD
W
G
-
Q
S
R
FGVYY
E
K
-----------
T
N
N
T
R
MN
E
-
----
G
LS
G
-----
G
GEGRI--L
A
GEKFTTN
R
L
S
S
W
RT
S
GEL
N
-
-
-
IPLNV
M
V
--
D
QT
----
--
--
--
--
--
LT
V
G
A
EWN
R
D
K
L
DDPSS
T
SLT
V
NDS
D
I
---
SG-
I
--
S
G
-
S
A
AD
------------------
R
S
S
K
NH
SQ
I
S
A
L
Y
I
ED
N
IE
PVP
G
T
N
I
I
P
GLRFD
YL
SDSGG
N
F
S
PSLNLSQEL
GD
Y
-
---F
K
VKA
G
V
A
RT
----------------
F
KA
P
N
LY
Q
S
S
E
G
--
-
Y
L
L
Y
S
----
-
K
G
N
G
CP
KDI
T
S
G
GCYLIGNK
D
L
D
P
E
I
S
V
N
K
EIG
L
EF
T
WE
D
-
-
Y
H
AS
V
T
Y
FR
N
D
YQ
NKI
V
A
G
D
N
VI
G
Q
T
AS
G
AYILK
W
Q
N
G
GKA
L
V
D
G
I
E
A
S
MS---F
P
L
V
KD
RLN
W
NT
N
A
T
W
M
IT
S
E
Q
K
D
T
----
-
-
-----
G
N
P
L
S
VI
P
K
Y
TIN
N
SLNW
TI
TQ
A
F
S
A
S
VNW
T
L
YG
RQK
P
RTH
AE
T
R
S
EDTGG
L
SGKELG
A
-
Y
SLV
G
T
N
FN
Y
D
I
N
KNL
R
LNVG
V
S
N
I
L
N
K
Q
I
F
R
SSE
-
-
-
-
-
---
-
-----
--
G
ANT
Y
N
-
E
PG
--
R
A
YY
A
GV
TAS
F
fig|656419.3.peg.1821
Escherichia coli M718 (3-725/725)
I
NK
I
L
W
SLT
V
L
---
-
L
V
G
L
N
S
Q
V
S
V
A
KS
S
D
D--DN
D
E
TLVV
E
A
T
A
E
Q
V
L
K
Q
Q
P
GV
S
---
-------------
V
I
T
S
EDIK
K
T
P
P
V
N
DLS
D
II
R
K
MPGVN
L
---
--
TGNS
A
S
G
T
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
V
P
VT
S
R
NSV
R
YS
W
RGE
RDT
RG
DT
N
WVPPE
Q
V
E
R
I
EV
I
RGP
A
AA
R
YG
S
G
A
A
GG
V
V
NIITK
R
P
TNDWH
G
SL
S
L
Y
T
N
Q
PE
S
SDEGATR
R
AN
FSL
S
GP
L
A
G
N
ALTT
RLYG
NLN
--
KT
D
A
D
SWD
IN
S
PV
G
TKNA-
---------
AG
H
EG
V
R
N
K
DINGV
V
S
WKL
N
P
Q
Q
I
LDFEA
G
YSRQGN
I
-
Y
AGD
TQ
NSSS
S
---------------
AV
T
ES
L
A
KS
G
K
-
E
T
NRL
Y
RQ
NY
G
I
T
H
N
GI
WD
W
G
-
Q
S
R
FGVYY
E
K
-----------
T
N
N
T
R
MN
E
-
----
G
LS
G
-----
G
GEGRI--L
A
GEKFTTN
R
L
S
S
W
RT
S
GEL
N
-
-
-
IPLNV
M
V
--
D
QT
----
--
--
--
--
--
LT
V
G
A
EWN
R
D
K
L
DDPSS
T
SLT
V
NDS
D
I
---
SG-
I
--
S
G
-
S
A
AD
------------------
R
S
S
K
NH
SQ
I
S
A
L
Y
I
ED
N
IE
PVP
G
T
N
I
I
P
GLRFD
YL
SDSGG
N
F
S
PSLNLSQEL
GD
Y
-
---F
K
VKA
G
V
A
RT
----------------
F
KA
P
N
LY
Q
S
S
E
G
--
-
Y
L
L
Y
S
----
-
K
G
N
G
CP
KDI
T
S
G
GCYLIGNK
D
L
D
P
E
I
S
V
N
K
EIG
L
EF
T
WE
D
-
-
Y
H
AS
V
T
Y
FR
N
D
YQ
NKI
V
A
G
D
N
VI
G
Q
T
AS
G
AYILK
W
Q
N
G
GKA
L
V
D
G
I
E
A
S
MS---F
P
L
V
KD
RLN
W
NT
N
A
T
W
M
IT
S
E
Q
K
D
T
----
-
-
-----
G
N
P
L
S
VI
P
K
Y
TIN
N
SLNW
TI
TQ
A
F
S
A
S
VNW
T
L
YG
RQK
P
RTH
AE
T
R
S
EDTGG
L
SGKELG
A
-
Y
SLV
G
T
N
FN
Y
D
I
N
KNL
R
LNVG
V
S
N
I
L
N
K
Q
I
F
R
SSE
-
-
-
-
-
---
-
-----
--
G
ANT
Y
N
-
E
PG
--
R
A
YY
A
GV
TAS
F
fig|685038.3.peg.4554
Escherichia coli O83:H1 str. NRG 857C (3-725/725)
I
NK
I
L
W
SLT
V
L
---
-
L
V
G
L
N
S
Q
V
S
V
A
KS
S
D
D--DN
D
E
TLVV
E
A
T
A
E
Q
V
L
K
Q
Q
P
GV
S
---
-------------
V
I
T
S
EDIK
K
T
P
P
V
N
DLS
D
II
R
K
MPGVN
L
---
--
TGNS
A
S
G
T
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
V
P
VT
S
R
NSV
R
YS
W
RGE
RDT
RG
DT
N
WVPPE
Q
V
E
R
I
EV
I
RGP
A
AA
R
YG
S
G
A
A
GG
V
V
NIITK
R
P
TNDWH
G
SL
S
L
Y
T
N
Q
PE
S
SDEGATR
R
AN
FSL
S
GP
L
A
G
N
ALTT
RLYG
NLN
--
KT
D
A
D
SWD
IN
S
PV
G
TKNA-
---------
AG
H
EG
V
R
N
K
DINGV
V
S
WKL
N
P
Q
Q
I
LDFEA
G
YSRQGN
I
-
Y
AGD
TQ
NSSS
S
---------------
AV
T
ES
L
A
KS
G
K
-
E
T
NRL
Y
RQ
NY
G
I
T
H
N
GI
WD
W
G
-
Q
S
R
FGVYY
E
K
-----------
T
N
N
T
R
MN
E
-
----
G
LS
G
-----
G
GEGRI--L
A
GEKFTTN
R
L
S
S
W
RT
S
GEL
N
-
-
-
IPLNV
M
V
--
D
QT
----
--
--
--
--
--
LT
V
G
A
EWN
R
D
K
L
DDPSS
T
SLT
V
NDS
D
I
---
SG-
I
--
S
G
-
S
A
AD
------------------
R
S
S
K
NH
SQ
I
S
A
L
Y
I
ED
N
IE
PVP
G
T
N
I
I
P
GLRFD
YL
SDSGG
N
F
S
PSLNLSQEL
GD
Y
-
---F
K
VKA
G
V
A
RT
----------------
F
KA
P
N
LY
Q
S
S
E
G
--
-
Y
L
L
Y
S
----
-
K
G
N
G
CP
KDI
T
S
G
GCYLIGNK
D
L
D
P
E
I
S
V
N
K
EIG
L
EF
T
WE
D
-
-
Y
H
AS
V
T
Y
FR
N
D
YQ
NKI
V
A
G
D
N
VI
G
Q
T
AS
G
AYILK
W
Q
N
G
GKA
L
V
D
G
I
E
A
S
MS---F
P
L
V
KD
RLN
W
NT
N
A
T
W
M
IT
S
E
Q
K
D
T
----
-
-
-----
G
N
P
L
S
VI
P
K
Y
TIN
N
SLNW
TI
TQ
A
F
S
A
S
VNW
T
L
YG
RQK
P
RTH
AE
T
R
S
EDTGG
L
SGKELG
A
-
Y
SLV
G
T
N
FN
Y
D
I
N
KNL
R
LNVG
V
S
N
I
L
N
K
Q
I
F
R
SSE
-
-
-
-
-
---
-
-----
--
G
ANT
Y
N
-
E
PG
--
R
A
YY
A
GV
TAS
F
fig|869729.3.peg.2625
Escherichia coli UM146 (3-725/725)
I
NK
I
L
W
SLT
V
L
---
-
L
V
G
L
N
S
Q
V
S
V
A
KS
S
D
D--DN
D
E
TLVV
E
A
T
A
E
Q
V
L
K
Q
Q
P
GV
S
---
-------------
V
I
T
S
EDIK
K
T
P
P
V
N
DLS
D
II
R
K
MPGVN
L
---
--
TGNS
A
S
G
T
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
V
P
VT
S
R
NSV
R
YS
W
RGE
RDT
RG
DT
N
WVPPE
Q
V
E
R
I
EV
I
RGP
A
AA
R
YG
S
G
A
A
GG
V
V
NIITK
R
P
TNDWH
G
SL
S
L
Y
T
N
Q
PE
S
SDEGATR
R
AN
FSL
S
GP
L
A
G
N
ALTT
RLYG
NLN
--
KT
D
A
D
SWD
IN
S
PV
G
TKNA-
---------
AG
H
EG
V
R
N
K
DINGV
V
S
WKL
N
P
Q
Q
I
LDFEA
G
YSRQGN
I
-
Y
AGD
TQ
NSSS
S
---------------
AV
T
ES
L
A
KS
G
K
-
E
T
NRL
Y
RQ
NY
G
I
T
H
N
GI
WD
W
G
-
Q
S
R
FGVYY
E
K
-----------
T
N
N
T
R
MN
E
-
----
G
LS
G
-----
G
GEGRI--L
A
GEKFTTN
R
L
S
S
W
RT
S
GEL
N
-
-
-
IPLNV
M
V
--
D
QT
----
--
--
--
--
--
LT
V
G
A
EWN
R
D
K
L
DDPSS
T
SLT
V
NDS
D
I
---
SG-
I
--
S
G
-
S
A
AD
------------------
R
S
S
K
NH
SQ
I
S
A
L
Y
I
ED
N
IE
PVP
G
T
N
I
I
P
GLRFD
YL
SDSGG
N
F
S
PSLNLSQEL
GD
Y
-
---F
K
VKA
G
V
A
RT
----------------
F
KA
P
N
LY
Q
S
S
E
G
--
-
Y
L
L
Y
S
----
-
K
G
N
G
CP
KDI
T
S
G
GCYLIGNK
D
L
D
P
E
I
S
V
N
K
EIG
L
EF
T
WE
D
-
-
Y
H
AS
V
T
Y
FR
N
D
YQ
NKI
V
A
G
D
N
VI
G
Q
T
AS
G
AYILK
W
Q
N
G
GKA
L
V
D
G
I
E
A
S
MS---F
P
L
V
KD
RLN
W
NT
N
A
T
W
M
IT
S
E
Q
K
D
T
----
-
-
-----
G
N
P
L
S
VI
P
K
Y
TIN
N
SLNW
TI
TQ
A
F
S
A
S
VNW
T
L
YG
RQK
P
RTH
AE
T
R
S
EDTGG
L
SGKELG
A
-
Y
SLV
G
T
N
FN
Y
D
I
N
KNL
R
LNVG
V
S
N
I
L
N
K
Q
I
F
R
SSE
-
-
-
-
-
---
-
-----
--
G
ANT
Y
N
-
E
PG
--
R
A
YY
A
GV
TAS
F
fig|364106.7.peg.1199
Escherichia coli UTI89 (3-725/725)
I
NK
I
L
W
SLT
V
L
---
-
L
V
G
L
N
S
Q
V
S
V
A
KS
S
D
D--DN
D
E
TLVV
E
A
T
A
E
Q
V
L
K
Q
Q
P
GV
S
---
-------------
V
I
T
S
EDIK
K
T
P
P
V
N
DLS
D
II
R
K
MPGVN
L
---
--
TGNS
A
S
G
T
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
V
P
VT
S
R
NSV
R
YS
W
RGE
RDT
RG
DT
N
WVPPE
Q
V
E
R
I
EV
I
RGP
A
AA
R
YG
S
G
A
A
GG
V
V
NIITK
R
P
TNDWH
G
SL
S
L
Y
T
N
Q
PE
S
SDEGATR
R
AN
FSL
S
GP
L
A
G
N
ALTT
RLYG
NLN
--
KT
D
A
D
SWD
IN
S
PV
G
TKNA-
---------
AG
H
EG
V
R
N
K
DINGV
V
S
WKL
N
P
Q
Q
I
LDFEA
G
YSRQGN
I
-
Y
AGD
TQ
NSSS
S
---------------
AV
T
ES
L
A
KS
G
K
-
E
T
NRL
Y
RQ
NY
G
I
T
H
N
GI
WD
W
G
-
Q
S
R
FGVYY
E
K
-----------
T
N
N
T
R
MN
E
-
----
G
LS
G
-----
G
GEGRI--L
A
GEKFTTN
R
L
S
S
W
RT
S
GEL
N
-
-
-
IPLNV
M
V
--
D
QT
----
--
--
--
--
--
LT
V
G
A
EWN
R
D
K
L
DDPSS
T
SLT
V
NDS
D
I
---
SG-
I
--
S
G
-
S
A
AD
------------------
R
S
S
K
NH
SQ
I
S
A
L
Y
I
ED
N
IE
PVP
G
T
N
I
I
P
GLRFD
YL
SDSGG
N
F
S
PSLNLSQEL
GD
Y
-
---F
K
VKA
G
V
A
RT
----------------
F
KA
P
N
LY
Q
S
S
E
G
--
-
Y
L
L
Y
S
----
-
K
G
N
G
CP
KDI
T
S
G
GCYLIGNK
D
L
D
P
E
I
S
V
N
K
EIG
L
EF
T
WE
D
-
-
Y
H
AS
V
T
Y
FR
N
D
YQ
NKI
V
A
G
D
N
VI
G
Q
T
AS
G
AYILK
W
Q
N
G
GKA
L
V
D
G
I
E
A
S
MS---F
P
L
V
KD
RLN
W
NT
N
A
T
W
M
IT
S
E
Q
K
D
T
----
-
-
-----
G
N
P
L
S
VI
P
K
Y
TIN
N
SLNW
TI
TQ
A
F
S
A
S
VNW
T
L
YG
RQK
P
RTH
AE
T
R
S
EDTGG
L
SGKELG
A
-
Y
SLV
G
T
N
FN
Y
D
I
N
KNL
R
LNVG
V
S
N
I
L
N
K
Q
I
F
R
SSE
-
-
-
-
-
---
-
-----
--
G
ANT
Y
N
-
E
PG
--
R
A
YY
A
GV
TAS
F
fig|364106.8.peg.1197
Escherichia coli UTI89 (3-725/725)
I
NK
I
L
W
SLT
V
L
---
-
L
V
G
L
N
S
Q
V
S
V
A
KS
S
D
D--DN
D
E
TLVV
E
A
T
A
E
Q
V
L
K
Q
Q
P
GV
S
---
-------------
V
I
T
S
EDIK
K
T
P
P
V
N
DLS
D
II
R
K
MPGVN
L
---
--
TGNS
A
S
G
T
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
V
P
VT
S
R
NSV
R
YS
W
RGE
RDT
RG
DT
N
WVPPE
Q
V
E
R
I
EV
I
RGP
A
AA
R
YG
S
G
A
A
GG
V
V
NIITK
R
P
TNDWH
G
SL
S
L
Y
T
N
Q
PE
S
SDEGATR
R
AN
FSL
S
GP
L
A
G
N
ALTT
RLYG
NLN
--
KT
D
A
D
SWD
IN
S
PV
G
TKNA-
---------
AG
H
EG
V
R
N
K
DINGV
V
S
WKL
N
P
Q
Q
I
LDFEA
G
YSRQGN
I
-
Y
AGD
TQ
NSSS
S
---------------
AV
T
ES
L
A
KS
G
K
-
E
T
NRL
Y
RQ
NY
G
I
T
H
N
GI
WD
W
G
-
Q
S
R
FGVYY
E
K
-----------
T
N
N
T
R
MN
E
-
----
G
LS
G
-----
G
GEGRI--L
A
GEKFTTN
R
L
S
S
W
RT
S
GEL
N
-
-
-
IPLNV
M
V
--
D
QT
----
--
--
--
--
--
LT
V
G
A
EWN
R
D
K
L
DDPSS
T
SLT
V
NDS
D
I
---
SG-
I
--
S
G
-
S
A
AD
------------------
R
S
S
K
NH
SQ
I
S
A
L
Y
I
ED
N
IE
PVP
G
T
N
I
I
P
GLRFD
YL
SDSGG
N
F
S
PSLNLSQEL
GD
Y
-
---F
K
VKA
G
V
A
RT
----------------
F
KA
P
N
LY
Q
S
S
E
G
--
-
Y
L
L
Y
S
----
-
K
G
N
G
CP
KDI
T
S
G
GCYLIGNK
D
L
D
P
E
I
S
V
N
K
EIG
L
EF
T
WE
D
-
-
Y
H
AS
V
T
Y
FR
N
D
YQ
NKI
V
A
G
D
N
VI
G
Q
T
AS
G
AYILK
W
Q
N
G
GKA
L
V
D
G
I
E
A
S
MS---F
P
L
V
KD
RLN
W
NT
N
A
T
W
M
IT
S
E
Q
K
D
T
----
-
-
-----
G
N
P
L
S
VI
P
K
Y
TIN
N
SLNW
TI
TQ
A
F
S
A
S
VNW
T
L
YG
RQK
P
RTH
AE
T
R
S
EDTGG
L
SGKELG
A
-
Y
SLV
G
T
N
FN
Y
D
I
N
KNL
R
LNVG
V
S
N
I
L
N
K
Q
I
F
R
SSE
-
-
-
-
-
---
-
-----
--
G
ANT
Y
N
-
E
PG
--
R
A
YY
A
GV
TAS
F
fig|585035.6.peg.5092
Escherichia coli S88 (3-720/720)
I
NK
I
L
W
SLT
V
L
---
-
L
V
G
L
N
S
Q
I
S
V
A
KS
S
D
D--DN
D
E
TLVV
E
A
T
A
E
Q
V
L
K
Q
Q
P
GV
S
---
-------------
V
I
T
S
EDIK
K
T
P
P
V
N
DLS
D
II
R
K
MPGVN
L
---
--
TGNS
A
S
G
T
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
V
P
VT
S
R
NSV
R
YS
W
RGE
RDT
RG
DT
N
WVPPE
Q
V
E
R
I
EV
I
RGP
A
AA
R
YG
S
G
A
A
GG
V
V
NIITK
R
P
TNDWH
G
SL
S
L
Y
T
N
Q
PE
S
SDEGATR
R
AN
FSL
S
GP
L
A
G
N
ALTT
RLYG
NLN
--
KT
D
A
D
SWD
IN
S
PV
G
TKNA-
---------
AG
H
EG
V
R
N
K
DINGV
V
S
WKL
N
P
Q
Q
I
LDFEA
G
YSRQGN
I
-
Y
AGD
TQ
NSSS
S
---------------
AV
T
ES
L
A
KS
G
K
-
E
T
NRL
Y
RQ
NY
G
I
T
H
N
GI
WD
W
G
-
Q
S
R
FGVYY
E
K
-----------
T
N
N
T
R
MN
E
-
----
G
LS
G
-----
G
GEGRI--L
A
GEKFTTN
R
L
S
S
W
RT
S
GEL
N
-
-
-
IPLNV
M
V
--
D
QT
----
--
--
--
--
--
LT
V
G
A
EWN
R
D
K
L
DDPSS
T
SLT
V
NDS
D
I
---
SG-
I
--
S
G
-
S
A
AD
------------------
R
S
S
K
NH
SQ
I
S
A
L
Y
I
ED
N
IE
PVP
G
T
N
I
I
P
GLRFD
YL
SDSGG
N
F
S
PSLNLSQEL
GD
Y
-
---F
K
VKA
G
V
A
RT
----------------
F
KA
P
N
LY
Q
S
S
E
G
--
-
Y
L
L
Y
S
----
-
K
G
N
G
CP
-
--
-
-
G
GCYLIGNK
D
L
D
P
E
I
S
V
N
K
EIG
L
EF
T
WE
D
-
-
Y
H
AS
V
T
Y
FR
N
D
YQ
NKI
V
A
G
D
N
VI
G
Q
T
AS
G
AYILK
W
Q
N
G
GKA
L
V
D
G
I
E
A
S
MS---F
P
L
V
KD
RLN
W
NT
N
A
T
W
M
IT
S
E
Q
K
D
T
----
-
-
-----
G
N
P
L
S
VI
P
K
Y
TIN
N
SLNW
TI
TQ
A
F
S
A
S
VNW
T
L
YG
RQK
P
RTH
AE
T
R
S
EDTGG
L
SGKELG
A
-
Y
SLV
G
T
N
FN
Y
D
I
N
KNL
R
LNVG
V
S
N
I
L
N
K
Q
I
F
R
SSE
-
-
-
-
-
---
-
-----
--
G
ANT
Y
N
-
E
PG
--
R
A
YY
A
GV
TAS
F
fig|679205.4.peg.4865
Escherichia coli MS 124-1 (3-722/722)
I
NK
I
L
W
SLT
V
L
---
-
L
V
G
L
N
S
Q
V
S
V
A
KS
S
D
D--DN
D
E
TLVV
E
A
T
A
E
Q
V
L
K
Q
Q
P
GV
S
---
-------------
V
I
T
S
EDIK
K
T
P
P
V
N
DLS
D
II
R
K
MPGVN
L
---
--
TGNS
A
S
G
T
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
V
P
VT
S
R
NSV
R
YS
W
RGE
RDT
RG
DT
N
WVPPE
Q
V
E
R
I
EV
I
RGP
A
AA
R
YG
S
G
A
A
GG
V
V
NIITK
R
P
TNDWH
G
SL
S
L
Y
T
N
Q
PE
S
SDEGATR
R
AN
FSL
S
GP
L
A
G
N
ALTT
RLYG
NLN
--
KT
D
A
D
SWD
IN
S
PV
G
TKNA-
---------
AG
H
EG
V
R
N
K
DINGV
V
S
WKL
N
P
Q
Q
I
LDFEA
G
YSRQGN
I
-
Y
AGD
TQ
NSSS
S
---------------
AV
T
ES
L
A
KS
G
K
-
E
T
NRL
Y
RQ
NY
G
I
T
H
N
GI
WD
W
G
-
Q
S
R
FGVYY
E
K
-----------
T
N
N
T
R
MN
E
-
----
G
LS
G
-----
G
GEGRI--L
A
GEKFTTN
R
L
S
S
W
RT
S
GEL
N
-
-
-
IPLNV
M
V
--
D
QT
----
--
--
--
--
--
LT
V
G
A
EWN
R
D
K
L
DDPSS
T
SLT
V
NDS
D
-
---
---
I
--
S
G
-
S
A
AD
------------------
R
S
S
K
NH
SQ
I
S
A
L
Y
I
ED
N
IE
PVP
G
T
N
I
I
P
G
V
RFD
YL
SDSGG
N
F
S
PSLNLSQEL
GD
Y
-
---F
K
VKA
G
V
A
RT
----------------
F
KA
P
N
LY
Q
S
S
E
G
--
-
Y
L
L
Y
S
----
-
K
G
N
G
CP
KDI
T
S
G
GCYLIGNK
D
L
D
P
E
I
S
V
N
K
EIG
L
EF
T
WE
D
-
-
Y
H
AS
V
T
Y
FR
N
D
YQ
NKI
V
A
G
D
N
VI
G
Q
T
AS
G
AYILK
W
Q
N
G
GKA
L
V
D
G
I
E
A
S
MS---F
P
L
V
KD
RLN
W
NT
N
A
T
W
M
IT
S
E
Q
K
D
T
----
-
-
-----
G
N
P
L
S
VI
P
K
Y
TIN
N
SLNW
TI
TQ
A
F
S
A
S
VNW
T
L
YG
RQK
P
RTH
AE
T
R
S
EDTGG
L
SGKELG
A
-
Y
SLV
G
T
N
FN
Y
D
I
N
KNL
R
LNVG
V
S
N
I
L
N
K
Q
I
F
R
SSE
-
-
-
-
-
---
-
-----
--
G
ANT
Y
N
-
E
PG
--
R
A
YY
A
GV
TAS
F
fig|749533.3.peg.3468
Escherichia coli MS 84-1 (3-722/722)
I
NK
I
L
W
SLT
V
L
---
-
L
V
G
L
N
S
Q
V
S
V
A
KS
S
D
D--DN
D
E
TLVV
E
A
T
A
E
Q
V
L
K
Q
Q
P
GV
S
---
-------------
V
I
T
S
EDIK
K
T
P
P
V
N
DLS
D
II
R
K
MPGVN
L
---
--
TGNS
A
S
G
T
RGNNR
Q
I
D
IRG
MGPE
N
TL
------
I
L
IDG
V
P
VT
S
R
NSV
R
YS
W
RGE
RDT
RG
DT
N
WVPPE
Q
V
E
R
I
EV
I
RGP
A
AA
R
YG
S
G
A
A
GG
V
V
NIITK
R
P
TNDWH
G
SL
S
L
Y
T
N
Q
PE
S
SDEGATR
R
AN
FSL
S
GP
L
A
G
N
ALTT
RLYG
NLN
--
KT
D
A
D
SWD
IN
S
PV
G
TKNA-
---------
AG
H
EG
V
R
N
K
DINGV
V
S
WKL
N
P
Q
Q
I
LDFEA
G
YSRQGN
I
-
Y
AGD
TQ
NSSS
S
---------------
AV
T
ES
L
A
KS
G
K
-
E
T
NRL
Y
RQ
NY
G
I
T
H
N
GI
WD
W
G
-
Q
S
R
FGVYY
E
K
-----------
T
N
N
T
R
MN
E
-
----
G
LS
G
-----
G
GEGRI--L
A
GEKFTTN
R
L
S
S
W
RT
S
GEL
N
-
-
-
IPLNV
M
V
--
D
QT
----
--
--
--
--
--
LT
V
G
A
EWN
R
D
K
L
DDPSS
T
SLT
V
NDS
D
-
---
---
I
--
S
G
-
S
A
AD
------------------
R
S
S
K
NH
SQ
I
S
A
L
Y
I
ED
N
IE
PVP
G
T
N
I
I
P
G
V
RFD
YL
SDSGG
N
F
S
PSLNLSQEL
GD
Y
-
---F
K
VKA
G
V
A
RT
----------------
F
KA
P
N
LY
Q
S
S
E
G
--
-
Y
L
L
Y
S
----
-
K
G
N
G
CP
KDI
T
S
G
GCYLIGNK
D
L
D
P
E
I
S
V
N
K
EIG
L
EF
T
WE
D
-
-
Y
H
AS
V
T
Y
FR
N
D
YQ
NKI
V
A
G
D
N
VI
G
Q
T
AS
G
AYILK
W
Q
N
G
GKA
L
V
D
G
I
E
A
S
MS---F
P
L
V
KD
RLN
W
NT
N
A
T
W
M
IT
S
E
Q
K
D
T
----
-
-
-----
G
N
P
L
S
VI
P
K
Y
TIN
N
SLNW
TI
TQ
A
F
S
A
S
VNW
T
L
YG
RQK
P
RTH
AE
T
R
S
EDTGG
L
SGKELG
A
-
Y
SLV
G
T
N
FN
Y
D
I
N
KNL
R
LNVG
V
S
N
I
L
N
K
Q
I
F
R
SSE
-
-
-
-
-
---
-
-----
--
G
ANT
Y
N
-
E
PG
--
R
A
YY
A
GV
TAS
F
fig|685038.3.peg.731
Escherichia coli O83:H1 str. NRG 857C (10-760/760)
RQF
HSLT
FFAG
L
-
CI
G
IT
-
P
V
A
Q
A
LA
A
E
GQANA
DDTLVV
E
A
-
S
T
P
SL
-
Y
AP
QQ
S
ADP
KFSRPVADTTRTM
TV
I
S
EQVI
KD
Q
GAT
NLT
D
AL
K
N
V
PGV
G
A
FFA
GE
N
GNST
T
G
D
-----
A
I
Y
M
RG
ADTS
N
S-
------
IYIDG
-
-
IR
D
I
G
SV
----
--S
RDT
FN
---------
T
E
Q
VEV
IK
GP
S
GT
D
YG
R
SA
P
T
G
S
IN
M
I
S
KQP
RN---
-
--
D
S
G
I
D
A
SA
S
IGSAWFR
R
GT
L
D
V
N
QV
I
-
GD
TTAM
RL
NV
MGE
--
KT
H
D
-
---
--
-
--
-
-----
---------
AGR
DK
V
K
N
E
-----
-
R
YGV
AP
--
S
VAFGL
G
TANRLY
L
N
Y
LHV
TQ
HNTP
D
GGIPTIGLPGYSAPS
AG
T
AA
LN
HS
G
K
V
D
T
HNF
Y
GT
--
-
---
D
SD
Y
D
D
S
I
T
D
T
ATMRF
EH
DINDNTTIRNT
TR
W
SR
VK
QD
YLMT
A
IM
G
-----
G
ASNITQPT
S
-------
D
V
N
S
W
T
W
S
RTA
NT
K
D
VSNKI
L
T
--
NQT
NLTS
TF
YT
G
A
IG
HD
L
S
T
G
V
E
FTR
E
T
Q
TNYGV
N
PVT
L
PAV
N
I
YHP
DSS
I
HP
G
GL
T
R
NG
------------------
A
N
A
N
GQ
TD
TFA
I
YA
FD
T
LQ
I
T
R
D
F
E
L
N
GG
I
R
L
D
-
-
-----
NYH
TEYDSATAC
G
G
S
G
RGAI
T
CPA
G
V
A
KG
SPVTTVDTAKSGNLVN
W
KA
G
ALY
H
LT
E
N
GN
V
YI
N
YA
VSQQ
P
P
G
G
N
NF
A
LA
Q
S
G
SGNSANRT
DFK
PQ
K
ANT
S
EIGT
KWQ
VL
D
K
R
L
L
LT
A
A
L
FR
T
D
IE
N
EV
E
-
-
-
-
--
-
QN
DD
GT
----
Y
S
Q
Y
GK
K
R
VEG
Y
E
I
S
VAGNIT
P
----
--A
W
QM
I
G
G
Y
---
T
Q
Q
K
A
T
IKNG
K
D
VAQDG
S
S
S
LP
YT
PE
H
AFT
L
WSQY
QA
TD
D
I
S
V
G
AGA
R
Y
I
G
S--
-
---
-
M
H
KG
SDGAV
G
TPAFTE
G
-
Y
WVA
D
A
K
LG
Y
R
V
N
R
NL
D
FQLN
V
Y
NLFD
-
-
-
------
-
-
-
-
---
-
T
D
YVA
SI
N
KSG
Y
R
Y
H
PG
EP
RT
FL
L
TA
N
M
HF
fig|585397.7.peg.778
Escherichia coli ED1a (10-760/760)
RQF
HSLT
FFAG
L
-
CI
G
IT
-
P
V
A
Q
A
LA
A
E
GQANA
DDTLVV
E
A
-
S
T
P
SL
-
Y
AP
QQ
S
ADP
KFSRPVADTTRTM
TV
I
S
EQVI
KD
Q
GAT
NLT
D
AL
K
N
V
PGV
G
A
FFA
GE
N
GNST
T
G
D
-----
A
I
Y
M
RG
ADTS
N
S-
------
IYIDG
-
-
IR
D
I
G
SV
----
--S
RDT
FN
---------
T
E
Q
VEV
IK
GP
S
GT
D
YG
R
SA
P
T
G
S
IN
M
I
S
KQP
RN---
-
--
D
S
G
I
D
A
SA
S
IGSAWFR
R
GT
L
D
V
N
QV
I
-
GD
TTAV
RL
NV
MGE
--
KT
H
D
-
---
--
-
--
-
-----
---------
AGR
DK
V
K
N
E
-----
-
R
YGV
AP
--
S
VAFGL
G
TANRLY
L
N
Y
LHV
TQ
HNTP
D
GGIPTIGLPGYSAPS
AG
T
AA
LN
HS
G
K
V
D
T
HNF
Y
GT
--
-
---
D
SD
Y
D
D
S
I
T
D
T
ATMRF
EH
DINDN
A
TIRNT
TR
W
SR
VK
QD
YLMT
A
IM
G
-----
G
ASNITQPT
S
-------
D
V
N
S
W
T
W
S
RTA
NT
K
D
VSNKI
L
T
--
NQT
NLTS
TF
YT
G
A
IG
HD
L
S
T
G
V
E
FTR
E
T
Q
TNYGV
N
PVT
L
PAV
N
I
YHP
DSS
I
HP
G
GL
T
R
NG
------------------
A
N
A
N
GQ
TD
TFA
I
YA
FD
T
LQ
I
T
R
D
F
E
L
N
GG
I
R
L
D
-
-
-----
NYH
TEYDSATAC
G
G
S
G
RGAI
T
CPA
G
V
A
KG
SPVTTVDTAKSGNLVN
W
KA
G
ALY
H
LT
E
N
GN
V
YI
N
YA
VSQQ
P
P
G
G
N
NF
A
LA
Q
S
G
SGNSANRT
DFK
PQ
K
ANT
S
EIGT
KWQ
VL
D
K
R
L
L
LT
A
A
L
FR
T
D
IE
N
EV
E
-
-
-
-
--
-
QN
DD
GT
----
Y
S
Q
Y
GK
K
R
VEG
Y
E
I
S
VAGNIT
P
----
--A
W
QM
I
G
G
Y
---
T
Q
Q
K
A
T
IKNG
K
D
VAQDG
S
S
S
LP
YT
PE
H
AFT
L
WSQY
QA
TD
D
I
S
V
G
AGA
R
Y
I
G
S--
-
---
-
M
H
KG
SDGAV
G
TPAFTE
G
-
Y
WVA
D
A
K
LG
Y
R
V
N
R
NL
D
FQLN
V
Y
NLFD
-
-
-
------
-
-
-
-
---
-
T
D
YVA
SI
N
KSG
Y
R
Y
H
PG
EP
RT
FL
L
TA
N
M
HF
fig|585397.9.peg.778
Escherichia coli ED1a (10-760/760)
RQF
HSLT
FFAG
L
-
CI
G
IT
-
P
V
A
Q
A
LA
A
E
GQANA
DDTLVV
E
A
-
S
T
P
SL
-
Y
AP
QQ
S
ADP
KFSRPVADTTRTM
TV
I
S
EQVI
KD
Q
GAT
NLT
D
AL
K
N
V
PGV
G
A
FFA
GE
N
GNST
T
G
D
-----
A
I
Y
M
RG
ADTS
N
S-
------
IYIDG
-
-
IR
D
I
G
SV
----
--S
RDT
FN
---------
T
E
Q
VEV
IK
GP
S
GT
D
YG
R
SA
P
T
G
S
IN
M
I
S
KQP
RN---
-
--
D
S
G
I
D
A
SA
S
IGSAWFR
R
GT
L
D
V
N
QV
I
-
GD
TTAV
RL
NV
MGE
--
KT
H
D
-
---
--
-
--
-
-----
---------
AGR
DK
V
K
N
E
-----
-
R
YGV
AP
--
S
VAFGL
G
TANRLY
L
N
Y
LHV
TQ
HNTP
D
GGIPTIGLPGYSAPS
AG
T
AA
LN
HS
G
K
V
D
T
HNF
Y
GT
--
-
---
D
SD
Y
D
D
S
I
T
D
T
ATMRF
EH
DINDN
A
TIRNT
TR
W
SR
VK
QD
YLMT
A
IM
G
-----
G
ASNITQPT
S
-------
D
V
N
S
W
T
W
S
RTA
NT
K
D
VSNKI
L
T
--
NQT
NLTS
TF
YT
G
A
IG
HD
L
S
T
G
V
E
FTR
E
T
Q
TNYGV
N
PVT
L
PAV
N
I
YHP
DSS
I
HP
G
GL
T
R
NG
------------------
A
N
A
N
GQ
TD
TFA
I
YA
FD
T
LQ
I
T
R
D
F
E
L
N
GG
I
R
L
D
-
-
-----
NYH
TEYDSATAC
G
G
S
G
RGAI
T
CPA
G
V
A
KG
SPVTTVDTAKSGNLVN
W
KA
G
ALY
H
LT
E
N
GN
V
YI
N
YA
VSQQ
P
P
G
G
N
NF
A
LA
Q
S
G
SGNSANRT
DFK
PQ
K
ANT
S
EIGT
KWQ
VL
D
K
R
L
L
LT
A
A
L
FR
T
D
IE
N
EV
E
-
-
-
-
--
-
QN
DD
GT
----
Y
S
Q
Y
GK
K
R
VEG
Y
E
I
S
VAGNIT
P
----
--A
W
QM
I
G
G
Y
---
T
Q
Q
K
A
T
IKNG
K
D
VAQDG
S
S
S
LP
YT
PE
H
AFT
L
WSQY
QA
TD
D
I
S
V
G
AGA
R
Y
I
G
S--
-
---
-
M
H
KG
SDGAV
G
TPAFTE
G
-
Y
WVA
D
A
K
LG
Y
R
V
N
R
NL
D
FQLN
V
Y
NLFD
-
-
-
------
-
-
-
-
---
-
T
D
YVA
SI
N
KSG
Y
R
Y
H
PG
EP
RT
FL
L
TA
N
M
HF
fig|753642.3.peg.860
Escherichia coli NC101 (10-760/760)
RQF
HSLT
FFAG
L
-
CI
G
IT
-
P
V
A
Q
A
LA
A
E
GQANA
DDTLVV
E
A
-
S
T
P
SL
-
Y
AP
QQ
S
ADP
KFSRPVADTTRTM
TV
I
S
EQVI
KD
Q
GAT
NLT
D
AL
K
N
V
PGV
G
A
FFA
GE
N
GNST
T
G
D
-----
A
I
Y
M
RG
ADTS
N
S-
------
IYIDG
-
-
IR
D
I
G
SV
----
--S
RDT
FN
---------
T
E
Q
VEV
IK
GP
S
GT
D
YG
R
SA
P
T
G
S
IN
M
I
S
KQP
RN---
-
--
D
S
G
I
D
A
SA
S
IGSAWFR
R
GT
L
D
V
N
QV
I
-
GD
TTAV
RL
NV
MGE
--
KT
H
D
-
---
--
-
--
-
-----
---------
AGR
DK
V
K
N
E
-----
-
R
YGV
AP
--
S
VAFGL
G
TANRLY
L
N
Y
LHV
TQ
HNTP
D
GGIPTIGLPGYSAPS
AG
T
AA
LN
HS
G
K
V
D
T
HNF
Y
GT
--
-
---
D
SD
Y
D
D
S
I
T
D
T
ATMRF
EH
DINDN
A
TIRNT
TR
W
SR
VK
QD
YLMT
A
IM
G
-----
G
ASNITQPT
S
-------
D
V
N
S
W
T
W
S
RTA
NT
K
D
VSNKI
L
T
--
NQT
NLTS
TF
YT
G
A
IG
HD
L
S
T
G
V
E
FTR
E
T
Q
TNYGV
N
PVT
L
PAV
N
I
YHP
DSS
I
HP
G
GL
T
R
NG
------------------
A
N
A
N
GQ
TD
TFA
I
YA
FD
T
LQ
I
T
R
D
F
E
L
N
GG
I
R
L
D
-
-
-----
NYH
TEYDSATAC
G
G
S
G
RGAI
T
CPA
G
V
A
KG
SPVTTVDTAKSGNLVN
W
KA
G
ALY
H
LT
E
N
GN
V
YI
N
YA
VSQQ
P
P
G
G
N
NF
A
LA
Q
S
G
SGNSANRT
DFK
PQ
K
ANT
S
EIGT
KWQ
VL
D
K
R
L
L
LT
A
A
L
FR
T
D
IE
N
EV
E
-
-
-
-
--
-
QN
DD
GT
----
Y
S
Q
Y
GK
K
R
VEG
Y
E
I
S
VAGNIT
P
----
--A
W
QM
I
G
G
Y
---
T
Q
Q
K
A
T
IKNG
K
D
VAQDG
S
S
S
LP
YT
PE
H
AFT
L
WSQY
QA
TD
D
I
S
V
G
AGA
R
Y
I
G
S--
-
---
-
M
H
KG
SDGAV
G
TPAFTE
G
-
Y
WVA
D
A
K
LG
Y
R
V
N
R
NL
D
FQLN
V
Y
NLFD
-
-
-
------
-
-
-
-
---
-
T
D
YVA
SI
N
KSG
Y
R
Y
H
PG
EP
RT
FL
L
TA
N
M
HF
fig|562.376.peg.4800
Escherichia coli WV_060327 (10-760/760)
RQF
HSLT
FFAG
L
-
CI
G
IT
-
P
V
A
Q
A
LA
A
E
GQANA
DDTLVV
E
A
-
S
T
P
SL
-
Y
AP
QQ
S
ADP
KFSRPVADTTRTM
TV
I
S
EQVI
KD
Q
GAT
NLT
D
AL
K
N
V
PGV
G
A
FFA
GE
N
GNST
T
G
D
-----
A
I
Y
M
RG
ADTS
N
S-
------
IYIDG
-
-
IR
D
I
G
SV
----
--S
RDT
FN
---------
T
E
Q
VEV
IK
GP
S
GT
D
YG
R
SA
P
T
G
S
IN
M
I
S
KQP
RN---
-
--
D
S
G
I
D
A
SA
S
IGSAWFR
R
GT
L
D
V
N
QV
I
-
GD
TTAV
RL
NV
MGE
--
KT
H
D
-
---
--
-
--
-
-----
---------
AGR
DK
V
K
N
E
-----
-
R
YGV
AP
--
S
VAFGL
G
TANRLY
L
N
Y
LHV
TQ
HNTP
D
GGIPTIGLPGYSAPS
AG
T
AA
LN
HS
G
K
V
D
T
HNF
Y
GT
--
-
---
D
SD
Y
D
D
S
I
T
D
T
ATMRF
EH
DINDN
A
TIRNT
TR
W
SR
VK
QD
YLMT
A
IM
G
-----
G
ASNITQPT
S
-------
D
V
N
S
W
T
W
S
RTA
NT
K
D
VSNKI
L
T
--
NQT
NLTS
TF
YT
G
A
IG
HDV
S
T
G
V
E
FTR
E
T
Q
TNYGV
N
PVT
L
PAV
N
I
YHP
DSS
I
HP
G
GL
T
R
NG
------------------
A
N
A
N
GQ
TD
TFA
I
YA
FD
T
LQ
I
T
R
D
F
E
L
N
GG
I
R
L
D
-
-
-----
NYH
TEYDSATAC
G
G
S
G
RGAI
T
CPA
G
V
A
KG
SPVTTVDTAKSGNLVN
W
KA
G
ALY
H
LT
E
N
GN
V
YI
N
YA
VSQQ
P
P
G
G
N
NF
A
LA
Q
S
G
SGNSANRT
DFK
PQ
K
ANT
S
EIGT
KWQ
VL
D
K
R
L
L
LT
A
A
L
FR
T
D
IE
N
EV
E
-
-
-
-
--
-
QN
DD
GT
----
Y
S
Q
Y
GK
K
R
VEG
Y
E
I
S
VAGNIT
P
----
--A
W
QM
I
G
G
Y
---
T
Q
Q
K
A
T
IKNG
K
D
VAQDG
S
S
S
LP
YT
PE
H
AFT
L
WSQY
QA
TD
D
I
S
V
G
AGA
R
Y
I
G
S--
-
---
-
M
H
KG
SDGAV
G
TPAFTE
G
-
Y
WVA
D
A
K
LG
Y
R
V
N
R
NL
D
FQLN
V
Y
NLFD
-
-
-
------
-
-
-
-
---
-
T
D
YVA
SI
N
KSG
Y
R
Y
H
PG
EP
RT
FL
L
TA
N
M
HF
fig|550676.3.peg.267
Escherichia coli B185 (10-760/760)
RQF
HSLT
FFAG
L
-
CI
G
IT
-
P
V
A
Q
A
LA
A
E
GQTNA
DDTLVV
E
A
-
S
T
P
SL
-
Y
AP
QQ
S
ADP
KFSRPVADTTRTM
TV
I
S
EQVI
KD
Q
GAT
NLT
D
AL
K
N
V
PGV
G
A
FFA
GE
N
GNST
T
G
D
-----
A
I
Y
M
RG
ADTS
N
S-
------
IYIDG
-
-
IR
D
I
G
SV
----
--S
RDT
FN
---------
T
E
Q
VEV
IK
GP
S
GT
D
YG
R
SA
P
T
G
S
IN
M
I
S
KQP
RN---
-
--
D
S
G
I
D
A
SA
S
IGSAWFR
R
GT
L
D
V
N
QV
I
-
GD
TTAV
RL
NV
MGE
--
KT
H
D
-
---
--
-
--
-
-----
---------
AGR
DK
V
K
N
E
-----
-
R
YGI
AP
--
S
VAFGL
G
TANRLY
L
N
Y
LHV
TQ
HNTP
D
GGIPTIGLPGYSAPS
AG
T
AT
LN
HS
G
K
V
D
T
HNF
Y
GT
--
-
---
D
SD
Y
D
D
S
T
T
D
T
ATMRF
EH
DINDNTTIRNT
TR
W
SR
VK
QD
YLMT
A
IM
G
-----
G
ASNITQPT
S
-------
D
V
N
S
W
T
W
S
RTA
NT
K
D
VSNKI
L
T
--
NQT
NLTS
TF
YT
GS
IG
HDV
S
T
G
V
E
FTR
E
T
Q
TNYGV
N
PVT
L
PAV
N
I
YHP
DSS
I
HP
G
GL
T
S
NG
------------------
A
N
A
N
GQ
TD
TFA
I
YA
FD
T
LQ
I
T
R
D
F
E
L
N
GG
I
R
L
D
-
-
-----
NYH
TEYDSATAC
G
G
S
G
RGAI
T
CPA
G
V
A
KG
SPVTTVDTAKSGNLVN
W
KA
G
ALY
H
LT
E
N
GN
V
YI
N
YA
VSQQ
P
P
G
G
N
NF
A
LA
Q
S
G
SGNSANRT
DFK
PQ
K
ANT
S
EIGT
KWQ
VL
D
K
R
L
L
LT
A
A
L
FR
T
D
IE
N
EV
E
-
-
-
-
--
-
QN
DD
GT
----
Y
S
Q
Y
GK
K
R
VEG
Y
E
I
S
VAGNIT
P
----
--A
W
QV
I
G
G
Y
---
T
Q
Q
K
A
T
IKNG
K
D
VAQDG
S
S
S
LP
YT
PE
H
AFT
L
WSQY
QA
TD
D
I
S
V
G
AGA
R
Y
I
G
S--
-
---
-
M
H
KG
SDGAV
G
TPAFTE
G
-
Y
WVA
D
A
K
LG
Y
R
V
N
R
NL
D
FQLN
V
Y
NLFD
-
-
-
------
-
-
-
-
---
-
T
D
YVA
SI
N
KSG
Y
R
Y
H
PG
EP
RT
FL
L
TA
N
M
HF
fig|439855.10.peg.986
Escherichia coli SMS-3-5 (10-760/760)
RQF
HSLT
FFAG
L
-
CI
G
IT
-
P
V
A
Q
A
LA
A
E
GQINA
DDTLVV
E
A
-
S
T
P
SL
-
Y
AP
QQ
S
ADP
KFSRPVADTTRTM
TV
I
S
EQVI
KD
Q
GAT
NLT
D
AL
K
N
V
PGV
G
A
FFA
GE
N
GNST
T
G
D
-----
A
I
Y
M
RG
ADTS
N
S-
------
IYIDG
-
-
IR
D
I
G
SV
----
--S
RDT
FN
---------
T
E
Q
VEV
IK
GP
S
GT
D
YG
R
SA
P
T
G
S
IN
M
I
S
KQP
RN---
-
--
D
S
G
I
D
A
SA
S
IGSAWFR
R
GT
L
D
V
N
QV
I
-
GD
TTAV
RL
NV
MGE
--
KT
H
D
-
---
--
-
--
-
-----
---------
AGR
DK
V
K
N
E
-----
-
R
YGV
AP
--
S
VAFGL
G
TANRLY
L
N
Y
LHV
TQ
HNTP
D
GGIPTIGLPGYSAPS
AG
T
AA
LN
HS
G
K
V
D
T
HNF
Y
GT
--
-
---
D
SD
Y
D
D
S
T
T
D
T
ATMRF
EH
DINDNTTIRNT
TR
W
SR
VK
QD
YLMT
A
IM
G
-----
G
ASNITQPT
S
-------
D
V
N
S
W
T
W
S
RTA
NT
K
D
VSNKI
L
T
--
NQT
NLTS
TF
YT
G
A
IG
HDV
S
T
G
V
E
FTR
E
T
Q
TNYGV
N
PVT
L
PAV
N
I
YHP
DSS
I
HP
G
GL
T
R
NG
------------------
A
N
A
N
GQ
TD
TFA
I
YA
FD
T
LQ
I
T
R
D
F
E
L
N
GG
I
R
L
D
-
-
-----
NYH
TEYDSATAC
G
G
S
G
RGAI
T
CPA
G
V
A
KG
SPVTTVDTA
R
SGNLVN
W
KA
G
ALY
H
LT
E
N
GN
V
YI
N
YA
VSQQ
P
P
G
G
N
NF
A
LA
Q
S
G
SGNSANRT
DFK
PQ
K
ANT
S
EIGT
KWQ
VL
D
K
R
L
L
LT
A
A
L
FR
T
D
IE
N
EV
E
-
-
-
-
--
-
QN
DD
GT
----
Y
S
Q
Y
GK
K
R
VEG
Y
E
I
S
GAGNIT
P
----
--A
W
QV
I
G
G
Y
---
T
Q
Q
K
A
T
IKNG
K
D
VAQDG
S
S
S
LP
YT
PE
H
AFT
L
WSQY
QA
TD
D
I
S
V
G
AGA
R
Y
I
G
S--
-
---
-
M
H
KG
SDGAV
G
TPAFTE
G
-
Y
WVA
D
A
K
LG
Y
R
V
N
R
NL
D
FQLN
V
Y
NLFD
-
-
-
------
-
-
-
-
---
-
T
D
YVA
SI
N
KSG
Y
R
Y
H
PG
EP
RT
FL
L
TA
N
M
HF
fig|525281.3.peg.2148
Escherichia coli 83972 (10-760/760)
RQF
HSLT
FFAG
L
-
CI
G
IT
-
P
V
A
Q
A
LA
A
E
GQANA
DDTLVV
E
A
-
S
T
P
SL
-
Y
AP
QQ
S
ADP
KFSRPVADTTRTM
TV
I
S
EQVI
KD
Q
GAT
NLT
D
AL
K
N
V
PGV
G
A
FFA
GE
N
GNST
T
G
D
-----
A
I
Y
M
RG
ADTS
N
S-
------
IYIDG
-
-
IR
D
I
G
SV
----
--S
RDT
FN
---------
T
E
Q
VEV
IK
GP
S
GT
D
YG
R
SA
P
T
G
S
IN
M
I
S
KQP
RN---
-
--
D
S
G
I
D
A
SA
S
IGSAWFR
R
GT
L
D
V
N
QV
I
-
GD
TTAV
RL
NV
MGE
--
KT
H
D
-
---
--
-
--
-
-----
---------
AGR
DK
V
K
N
E
-----
-
R
YGV
AP
--
S
VAFGL
G
TANRLY
L
N
Y
LHV
TQ
HNTP
D
GGIPTIGLPGYSAPS
AG
T
AA
LN
HS
G
K
V
D
T
HNF
Y
GT
--
-
---
D
SD
Y
D
D
S
T
T
D
T
ATMRF
EH
DINDNTTIRNT
TR
W
SR
VK
QD
YLMT
A
IM
G
-----
G
ASNITQPT
S
-------
D
V
N
S
W
T
W
S
RTA
NT
K
D
VSNKI
L
T
--
NQT
NLTS
TF
YT
G
A
IG
HD
L
S
T
G
V
E
FTR
E
T
Q
TNYGV
N
PVT
L
PAV
N
I
YHP
DSS
I
HP
G
GL
T
R
NG
------------------
A
N
A
N
GQ
TD
TFA
I
YA
FD
T
LQ
I
T
R
D
F
E
L
N
GG
I
R
L
D
-
-
-----
NYH
TEYDSATAC
G
G
S
G
RGAI
T
CPA
G
V
A
KG
SPVTTVDTAKSGNLVN
W
KA
G
ALY
H
LT
E
N
GN
V
YI
N
YA
VSQQ
P
P
G
G
N
NF
A
LA
Q
S
G
SGNSANRT
DFK
PQ
K
ANT
S
EIGT
KWQ
VL
D
K
R
L
L
LT
A
A
L
FR
T
D
IE
N
EV
E
-
-
-
-
--
-
QN
DD
GT
----
Y
S
Q
Y
GK
K
R
VEG
Y
E
I
S
VAGNIT
P
----
--A
W
QM
I
G
G
Y
---
T
Q
Q
K
A
T
IKNG
K
D
VAQDG
S
S
S
LP
YT
PE
H
AFT
L
WSQY
QA
TD
D
I
S
V
G
AGA
R
Y
I
G
S--
-
---
-
M
H
KG
SDGAV
G
TPAFTE
G
-
Y
WVA
D
A
K
LG
Y
R
V
N
R
NL
D
FQLN
V
Y
NLFD
-
-
-
------
-
-
-
-
---
-
T
D
YVA
SI
N
KSG
Y
R
Y
H
PG
EP
RT
FL
L
TA
N
M
HF
fig|655817.3.peg.890
Escherichia coli ABU 83972 (10-760/760)
RQF
HSLT
FFAG
L
-
CI
G
IT
-
P
V
A
Q
A
LA
A
E
GQANA
DDTLVV
E
A
-
S
T
P
SL
-
Y
AP
QQ
S
ADP
KFSRPVADTTRTM
TV
I
S
EQVI
KD
Q
GAT
NLT
D
AL
K
N
V
PGV
G
A
FFA
GE
N
GNST
T
G
D
-----
A
I
Y
M
RG
ADTS
N
S-
------
IYIDG
-
-
IR
D
I
G
SV
----
--S
RDT
FN
---------
T
E
Q
VEV
IK
GP
S
GT
D
YG
R
SA
P
T
G
S
IN
M
I
S
KQP
RN---
-
--
D
S
G
I
D
A
SA
S
IGSAWFR
R
GT
L
D
V
N
QV
I
-
GD
TTAV
RL
NV
MGE
--
KT
H
D
-
---
--
-
--
-
-----
---------
AGR
DK
V
K
N
E
-----
-
R
YGV
AP
--
S
VAFGL
G
TANRLY
L
N
Y
LHV
TQ
HNTP
D
GGIPTIGLPGYSAPS
AG
T
AA
LN
HS
G
K
V
D
T
HNF
Y
GT
--
-
---
D
SD
Y
D
D
S
T
T
D
T
ATMRF
EH
DINDNTTIRNT
TR
W
SR
VK
QD
YLMT
A
IM
G
-----
G
ASNITQPT
S
-------
D
V
N
S
W
T
W
S
RTA
NT
K
D
VSNKI
L
T
--
NQT
NLTS
TF
YT
G
A
IG
HD
L
S
T
G
V
E
FTR
E
T
Q
TNYGV
N
PVT
L
PAV
N
I
YHP
DSS
I
HP
G
GL
T
R
NG
------------------
A
N
A
N
GQ
TD
TFA
I
YA
FD
T
LQ
I
T
R
D
F
E
L
N
GG
I
R
L
D
-
-
-----
NYH
TEYDSATAC
G
G
S
G
RGAI
T
CPA
G
V
A
KG
SPVTTVDTAKSGNLVN
W
KA
G
ALY
H
LT
E
N
GN
V
YI
N
YA
VSQQ
P
P
G
G
N
NF
A
LA
Q
S
G
SGNSANRT
DFK
PQ
K
ANT
S
EIGT
KWQ
VL
D
K
R
L
L
LT
A
A
L
FR
T
D
IE
N
EV
E
-
-
-
-
--
-
QN
DD
GT
----
Y
S
Q
Y
GK
K
R
VEG
Y
E
I
S
VAGNIT
P
----
--A
W
QM
I
G
G
Y
---
T
Q
Q
K
A
T
IKNG
K
D
VAQDG
S
S
S
LP
YT
PE
H
AFT
L
WSQY
QA
TD
D
I
S
V
G
AGA
R
Y
I
G
S--
-
---
-
M
H
KG
SDGAV
G
TPAFTE
G
-
Y
WVA
D
A
K
LG
Y
R
V
N
R
NL
D
FQLN
V
Y
NLFD
-
-
-
------
-
-
-
-
---
-
T
D
YVA
SI
N
KSG
Y
R
Y
H
PG
EP
RT
FL
L
TA
N
M
HF
fig|749546.3.peg.4958
Escherichia coli MS 185-1 (10-760/760)
RQF
HSLT
FFAG
L
-
CI
G
IT
-
P
V
A
Q
A
LA
A
E
GQANA
DDTLVV
E
A
-
S
T
P
SL
-
Y
AP
QQ
S
ADP
KFSRPVADTTRTM
TV
I
S
EQVI
KD
Q
GAT
NLT
D
AL
K
N
V
PGV
G
A
FFA
GE
N
GNST
T
G
D
-----
A
I
Y
M
RG
ADTS
N
S-
------
IYIDG
-
-
IR
D
I
G
SV
----
--S
RDT
FN
---------
T
E
Q
VEV
IK
GP
S
GT
D
YG
R
SA
P
T
G
S
IN
M
I
S
KQP
RN---
-
--
D
S
G
I
D
A
SA
S
IGSAWFR
R
GT
L
D
V
N
QV
I
-
GD
TTAV
RL
NV
MGE
--
KT
H
D
-
---
--
-
--
-
-----
---------
AGR
DK
V
K
N
E
-----
-
R
YGV
AP
--
S
VAFGL
G
TANRLY
L
N
Y
LHV
TQ
HNTP
D
GGIPTIGLPGYSAPS
AG
T
AA
LN
HS
G
K
V
D
T
HNF
Y
GT
--
-
---
D
SD
Y
D
D
S
T
T
D
T
ATMRF
EH
DINDNTTIRNT
TR
W
SR
VK
QD
YLMT
A
IM
G
-----
G
ASNITQPT
S
-------
D
V
N
S
W
T
W
S
RTA
NT
K
D
VSNKI
L
T
--
NQT
NLTS
TF
YT
G
A
IG
HD
L
S
T
G
V
E
FTR
E
T
Q
TNYGV
N
PVT
L
PAV
N
I
YHP
DSS
I
HP
G
GL
T
R
NG
------------------
A
N
A
N
GQ
TD
TFA
I
YA
FD
T
LQ
I
T
R
D
F
E
L
N
GG
I
R
L
D
-
-
-----
NYH
TEYDSATAC
G
G
S
G
RGAI
T
CPA
G
V
A
KG
SPVTTVDTAKSGNLVN
W
KA
G
ALY
H
LT
E
N
GN
V
YI
N
YA
VSQQ
P
P
G
G
N
NF
A
LA
Q
S
G
SGNSANRT
DFK
PQ
K
ANT
S
EIGT
KWQ
VL
D
K
R
L
L
LT
A
A
L
FR
T
D
IE
N
EV
E
-
-
-
-
--
-
QN
DD
GT
----
Y
S
Q
Y
GK
K
R
VEG
Y
E
I
S
VAGNIT
P
----
--A
W
QM
I
G
G
Y
---
T
Q
Q
K
A
T
IKNG
K
D
VAQDG
S
S
S
LP
YT
PE
H
AFT
L
WSQY
QA
TD
D
I
S
V
G
AGA
R
Y
I
G
S--
-
---
-
M
H
KG
SDGAV
G
TPAFTE
G
-
Y
WVA
D
A
K
LG
Y
R
V
N
R
NL
D
FQLN
V
Y
NLFD
-
-
-
------
-
-
-
-
---
-
T
D
YVA
SI
N
KSG
Y
R
Y
H
PG
EP
RT
FL
L
TA
N
M
HF
fig|749528.3.peg.4543
Escherichia coli MS 45-1 (10-760/760)
RQF
HSLT
FFAG
L
-
CI
G
IT
-
P
V
A
Q
A
LA
A
E
GQANA
DDTLVV
E
A
-
S
T
P
SL
-
Y
AP
QQ
S
ADP
KFSRPVADTTRTM
TV
I
S
EQVI
KD
Q
GAT
NLT
D
AL
K
N
V
PGV
G
A
FFA
GE
N
GNST
T
G
D
-----
A
I
Y
M
RG
ADTS
N
S-
------
IYIDG
-
-
IR
D
I
G
SV
----
--S
RDT
FN
---------
T
E
Q
VEV
IK
GP
S
GT
D
YG
R
SA
P
T
G
S
IN
M
I
S
KQP
RN---
-
--
D
S
G
I
D
A
SA
S
IGSAWFR
R
GT
L
D
V
N
QV
I
-
GD
TTAV
RL
NV
MGE
--
KT
H
D
-
---
--
-
--
-
-----
---------
AGR
DK
V
K
N
E
-----
-
R
YGV
AP
--
S
VAFGL
G
TANRLY
L
N
Y
LHV
TQ
HNTP
D
GGIPTIGLPGYSAPS
AG
T
AA
LN
HS
G
K
V
D
T
HNF
Y
GT
--
-
---
D
SD
Y
D
D
S
T
T
D
T
ATMRF
EH
DINDNTTIRNT
TR
W
SR
VK
QD
YLMT
A
IM
G
-----
G
ASNITQPT
S
-------
D
V
N
S
W
T
W
S
RTA
NT
K
D
VSNKI
L
T
--
NQT
NLTS
TF
YT
G
A
IG
HD
L
S
T
G
V
E
FTR
E
T
Q
TNYGV
N
PVT
L
PAV
N
I
YHP
DSS
I
HP
G
GL
T
R
NG
------------------
A
N
A
N
GQ
TD
TFA
I
YA
FD
T
LQ
I
T
R
D
F
E
L
N
GG
I
R
L
D
-
-
-----
NYH
TEYDSATAC
G
G
S
G
RGAI
T
CPA
G
V
A
KG
SPVTTVDTAKSGNLVN
W
KA
G
ALY
H
LT
E
N
GN
V
YI
N
YA
VSQQ
P
P
G
G
N
NF
A
LA
Q
S
G
SGNSANRT
DFK
PQ
K
ANT
S
EIGT
KWQ
VL
D
K
R
L
L
LT
A
A
L
FR
T
D
IE
N
EV
E
-
-
-
-
--
-
QN
DD
GT
----
Y
S
Q
Y
GK
K
R
VEG
Y
E
I
S
VAGNIT
P
----
--A
W
QM
I
G
G
Y
---
T
Q
Q
K
A
T
IKNG
K
D
VAQDG
S
S
S
LP
YT
PE
H
AFT
L
WSQY
QA
TD
D
I
S
V
G
AGA
R
Y
I
G
S--
-
---
-
M
H
KG
SDGAV
G
TPAFTE
G
-
Y
WVA
D
A
K
LG
Y
R
V
N
R
NL
D
FQLN
V
Y
NLFD
-
-
-
------
-
-
-
-
---
-
T
D
YVA
SI
N
KSG
Y
R
Y
H
PG
EP
RT
FL
L
TA
N
M
HF
fig|562.372.peg.1095
Escherichia coli 1212A (10-760/760)
RQF
HSLT
FFAG
L
-
CI
G
IT
-
P
V
A
Q
A
LA
A
E
GQTNA
DDTLVV
E
A
-
S
T
P
SL
-
Y
AP
QQ
S
ADP
KFSRPVADTTRTM
TV
I
S
EQVI
KD
Q
GAT
NLT
D
AL
K
N
V
PGV
G
A
FFA
GE
N
GNST
T
G
D
-----
A
I
Y
M
RG
ADTS
N
S-
------
IYIDG
-
-
IR
D
I
G
SV
----
--S
RDT
FN
---------
T
E
Q
VEV
IK
GP
S
GT
D
YG
R
SA
P
T
G
S
IN
M
I
S
KQP
RN---
-
--
D
S
G
I
D
A
SA
S
IGSAWFR
R
GT
L
D
V
N
QV
I
-
GD
TTAV
RL
NV
MGE
--
KT
H
D
-
---
--
-
--
-
-----
---------
AGR
DK
V
K
N
E
-----
-
R
YGV
AP
--
S
IAFGL
G
TANRLY
L
N
Y
LHV
TQ
HNTP
D
GGIPTIGLPGYSAPS
AG
T
AT
LN
HS
G
K
V
D
T
HNF
Y
GT
--
-
---
D
SD
Y
D
D
S
T
T
D
T
ATMRF
EH
DINDNTTIRNT
TR
W
SR
VK
QD
YLMT
A
IM
G
-----
G
ASNITQPT
S
-------
D
V
N
S
W
T
W
S
RTA
NT
K
D
VSNKI
L
T
--
NQT
NLTS
TF
YT
A
S
IG
HDV
S
T
G
V
E
FTR
E
T
Q
TNYGV
N
PVT
L
PAV
N
I
YHP
DSS
I
HP
G
GL
T
R
NG
------------------
A
N
A
N
GQ
TD
TFA
I
YA
FD
T
LQ
I
T
R
D
F
E
L
N
GG
I
R
L
D
-
-
-----
NYH
TEYDSATAC
G
G
S
G
RGAI
T
CPA
G
V
A
KG
SPVTTVDTAKSGNLVN
W
KA
G
ALY
H
LT
E
N
GN
V
YI
N
YA
VSQQ
P
P
G
G
N
NF
A
LA
Q
S
G
SGNSANRT
DFK
PQ
K
ANT
S
EIGT
KWQ
VL
D
K
R
L
L
LT
A
A
L
FR
T
D
IE
N
EV
E
-
-
-
-
--
-
QN
DD
GT
----
Y
S
Q
Y
GK
K
R
VEG
Y
E
I
S
VAGNIT
P
----
--A
W
QV
I
G
G
Y
---
T
Q
Q
K
A
T
IKNG
K
D
VAQDG
S
S
S
LP
YT
PE
H
AFT
L
WSQY
QA
TD
D
I
S
V
G
AGA
R
Y
I
G
S--
-
---
-
M
H
KG
SDGAV
G
TPAFTE
G
-
Y
WVA
D
V
K
LG
Y
R
V
N
R
NL
D
FQLN
V
Y
NLFD
-
-
-
------
-
-
-
-
---
-
T
D
YVA
SI
N
KSG
Y
R
Y
H
PG
EP
RT
FL
L
TA
N
M
HF
fig|562.374.peg.2629
Escherichia coli 536A (10-760/760)
RQF
HSLT
FFAG
L
-
CI
G
IT
-
P
V
A
Q
A
LA
A
E
GQTNA
DDTLVV
E
A
-
S
T
P
SL
-
Y
AP
QQ
S
ADP
KFSRPVADTTRTM
TV
I
S
EQVI
KD
Q
GAT
NLT
D
AL
K
N
V
PGV
G
A
FFA
GE
N
GNST
T
G
D
-----
A
I
Y
M
RG
ADTS
N
S-
------
IYIDG
-
-
IR
D
I
G
SV
----
--S
RDT
FN
---------
T
E
Q
VEV
IK
GP
S
GT
D
YG
R
SA
P
T
G
S
IN
M
I
S
KQP
RN---
-
--
D
S
G
I
D
A
SA
S
IGSAWFR
R
GT
L
D
V
N
QV
I
-
GD
TTAV
RL
NV
MGE
--
KT
H
D
-
---
--
-
--
-
-----
---------
AGR
DK
V
K
N
E
-----
-
R
YGV
AP
--
S
IAFGL
G
TANRLY
L
N
Y
LHV
TQ
HNTP
D
GGIPTIGLPGYSAPS
AG
T
AT
LN
HS
G
K
V
D
T
HNF
Y
GT
--
-
---
D
SD
Y
D
D
S
T
T
D
T
ATMRF
EH
DINDNTTIRNT
TR
W
SR
VK
QD
YLMT
A
IM
G
-----
G
ASNITQPT
S
-------
D
V
N
S
W
T
W
S
RTA
NT
K
D
VSNKI
L
T
--
NQT
NLTS
TF
YT
A
S
IG
HDV
S
T
G
V
E
FTR
E
T
Q
TNYGV
N
PVT
L
PAV
N
I
YHP
DSS
I
HP
G
GL
T
R
NG
------------------
A
N
A
N
GQ
TD
TFA
I
YA
FD
T
LQ
I
T
R
D
F
E
L
N
GG
I
R
L
D
-
-
-----
NYH
TEYDSATAC
G
G
S
G
RGAI
T
CPA
G
V
A
KG
SPVTTVDTAKSGNLVN
W
KA
G
ALY
H
LT
E
N
GN
V
YI
N
YA
VSQQ
P
P
G
G
N
NF
A
LA
Q
S
G
SGNSANRT
DFK
PQ
K
ANT
S
EIGT
KWQ
VL
D
K
R
L
L
LT
A
A
L
FR
T
D
IE
N
EV
E
-
-
-
-
--
-
QN
DD
GT
----
Y
S
Q
Y
GK
K
R
VEG
Y
E
I
S
VAGNIT
P
----
--A
W
QV
I
G
G
Y
---
T
Q
Q
K
A
T
IKNG
K
D
VAQDG
S
S
S
LP
YT
PE
H
AFT
L
WSQY
QA
TD
D
I
S
V
G
AGA
R
Y
I
G
S--
-
---
-
M
H
KG
SDGAV
G
TPAFTE
G
-
Y
WVA
D
V
K
LG
Y
R
V
N
R
NL
D
FQLN
V
Y
NLFD
-
-
-
------
-
-
-
-
---
-
T
D
YVA
SI
N
KSG
Y
R
Y
H
PG
EP
RT
FL
L
TA
N
M
HF
fig|679206.4.peg.4022
Escherichia coli MS 119-7 (10-760/760)
RQF
HSLT
FFAG
L
-
CI
G
IT
-
P
V
A
Q
A
LA
A
E
GQTNA
DDTLVV
E
A
-
S
T
P
SL
-
Y
AP
QQ
S
ADP
KFSRPVADTTRTM
TV
I
S
EQVI
KD
Q
GAT
NLT
D
AL
K
N
V
PGV
G
A
FFA
GE
N
GNST
T
G
D
-----
A
I
Y
M
RG
ADTS
N
S-
------
IYIDG
-
-
IR
D
I
G
SV
----
--S
RDT
FN
---------
T
E
Q
VEV
IK
GP
S
GT
D
YG
R
SA
P
T
G
S
IN
M
I
S
KQP
RN---
-
--
D
S
G
I
D
A
SA
S
IGSAWFR
R
GT
L
D
V
N
QV
I
-
GD
TTAV
RL
NV
MGE
--
KT
H
D
-
---
--
-
--
-
-----
---------
AGR
DK
V
K
N
E
-----
-
R
YGV
AP
--
S
IAFGL
G
TANRLY
L
N
Y
LHV
TQ
HNTP
D
GGIPTIGLPGYSAPS
AG
T
AA
LN
HS
G
K
V
D
T
HNF
Y
GT
--
-
---
D
SD
Y
D
D
S
T
T
D
T
ATMRF
EH
DINDNTTIRNT
TR
W
SR
VK
QD
YLMT
A
IM
G
-----
G
ASNITQPT
S
-------
D
V
N
S
W
T
W
S
RTA
NT
K
D
VSNKI
L
T
--
NQT
NLTS
TF
YT
GS
IG
HDV
T
T
G
V
E
FTR
E
T
Q
TNYGV
N
PVT
L
PAV
N
I
YHP
DSS
I
HP
G
GL
T
R
NG
------------------
A
N
A
N
GQ
TD
TFA
I
YA
FD
T
LQ
I
T
R
D
F
E
L
N
GG
I
R
L
D
-
-
-----
NYH
TEYDSATAC
G
G
S
G
RGAI
T
CPT
G
V
A
KG
SPVTTVDTAKSGNLVN
W
KA
G
ALY
H
LT
E
N
GN
V
YI
N
YA
VSQQ
P
P
G
G
N
NF
A
LA
Q
S
G
SGNSANRT
DFK
PQ
K
ANT
S
EIGT
KWQ
VL
D
K
R
L
L
LT
A
A
L
FR
T
D
IE
N
EV
E
-
-
-
-
--
-
QN
DD
GT
----
Y
S
Q
Y
GK
K
R
VEG
Y
E
I
S
VAGNIT
P
----
--A
W
QV
I
G
G
Y
---
T
Q
Q
K
A
T
IKNG
K
D
VAQDG
S
S
S
LP
YT
PE
H
AFT
L
WSQY
QA
TD
D
I
S
V
G
AGA
R
Y
I
G
S--
-
---
-
M
H
KG
SDGAV
G
TPAFTE
G
-
Y
WVA
D
A
K
LG
Y
R
V
N
R
NL
D
FQLN
V
Y
NLFD
-
-
-
------
-
-
-
-
---
-
T
D
YVA
SI
N
KSG
Y
R
Y
H
PG
EP
RT
FL
L
TA
N
M
HF
fig|340185.3.peg.2852
Escherichia coli E22 (10-760/760)
RQF
HSLT
FFAG
L
-
CI
G
IT
-
P
V
A
Q
A
LA
A
E
GQTNA
DDTLVV
E
A
-
S
T
P
SL
-
Y
AP
QQ
S
ADP
KFSRPVADTTRTM
TV
I
S
EQVI
KD
Q
GAT
NLT
D
AL
K
N
V
PGV
G
A
FFA
GE
N
GNST
T
G
D
-----
A
I
Y
M
RG
ADTS
N
S-
------
IYIDG
-
-
IR
D
I
G
SV
----
--S
RDT
FN
---------
T
E
Q
VEV
IK
GP
S
GT
D
YG
R
SA
P
T
G
S
IN
M
I
S
KQP
RN---
-
--
D
S
G
I
D
A
SA
S
IGSAWFR
R
GT
L
D
V
N
QV
I
-
GD
TTAV
RL
NV
MGE
--
KT
H
D
-
---
--
-
--
-
-----
---------
AGR
DK
V
K
N
E
-----
-
R
YGV
AP
--
S
IAFGL
G
TANRLY
L
N
Y
LHV
TQ
HNTP
D
GGIPTIGLPGYSAPS
AG
T
AA
LN
HS
G
K
V
D
T
HNF
Y
GT
--
-
---
D
SD
Y
D
D
S
T
T
D
T
ATMRF
EH
DINDNTTIRNT
TR
W
SR
VK
QD
YLMT
A
IM
G
-----
G
ASNITQPT
S
-------
D
V
N
S
W
T
W
S
RTA
NT
K
D
VSNKI
L
T
--
NQT
NLTS
TF
YT
GS
IG
HDV
S
T
G
V
E
FTR
E
T
Q
TNYGV
N
PMT
L
PAV
N
I
YHP
DSS
I
HP
G
GL
T
R
NG
------------------
A
N
A
N
GQ
TD
TFA
I
YA
FD
T
LQ
I
T
R
D
F
E
L
N
GG
I
R
L
D
-
-
-----
NYH
TEYDSATAC
G
G
S
G
RGAI
T
CPA
G
V
A
KG
SPVTTVDTAKSGNLVN
W
KA
G
ALY
H
LT
E
N
GN
V
YI
N
YA
VSQQ
P
P
G
G
N
NF
A
LA
Q
S
G
SGNSANRT
DFK
PQ
K
ANT
S
EIGT
KWQ
VL
D
K
R
L
L
LT
A
A
L
FR
T
D
IE
N
EV
E
-
-
-
-
--
-
QN
DD
GT
----
Y
S
Q
Y
GK
K
R
VEG
Y
E
I
S
VAGNIT
P
----
--A
W
QV
I
G
G
Y
---
T
Q
Q
K
A
T
IKNG
K
D
VAQDG
S
S
S
LP
YT
PE
H
AFT
L
WSQY
QA
TD
D
I
S
V
G
AGA
R
Y
I
G
S--
-
---
-
M
H
KG
SDGAV
G
TPAFTE
G
-
Y
WVA
D
A
K
LG
Y
R
V
N
R
NL
D
FQLN
V
Y
NLFD
-
-
-
------
-
-
-
-
---
-
T
D
YVA
SI
N
KSG
Y
R
Y
H
PG
EP
RT
FL
L
TA
N
M
HF
fig|749531.3.peg.1749
Escherichia coli MS 69-1 (10-760/760)
RQF
HSLT
FFAG
L
-
CI
G
IT
-
P
V
A
Q
A
LA
A
E
GQANA
DDTLVV
E
A
-
S
T
P
SL
-
Y
AP
QQ
S
ADP
KFSRPVADTTRTM
TV
I
S
EQVI
KD
Q
GAT
NLT
D
AL
K
N
V
PGV
G
A
FFA
GE
N
GNST
T
G
D
-----
A
I
Y
M
RG
ADTS
N
S-
------
IYIDG
-
-
IR
D
I
G
SV
----
--S
RDT
FN
---------
T
E
Q
VEV
IK
GP
S
GT
D
YG
R
SA
P
T
G
S
IN
M
I
S
KQP
RN---
-
--
D
S
G
I
D
A
SA
S
IGSAWFR
R
GT
L
D
V
N
Q
A
I
-
GD
TTAV
RL
NV
MGE
--
KT
H
D
-
---
--
-
--
-
-----
---------
AGR
DK
I
K
N
E
-----
-
R
YGV
AP
--
S
VAFGL
G
TANRLY
L
N
Y
LHV
TQ
HNTP
D
GGIPTIGLPGYSAPS
AG
T
AA
LN
HS
G
K
V
D
T
HNF
Y
GT
--
-
---
D
SD
Y
D
D
S
T
T
D
T
ATMRF
EH
DINDNTTIRNT
TR
W
SR
VK
QD
YLMT
A
IM
G
-----
G
ASNITQPT
S
-------
D
V
N
S
W
T
W
S
RTA
NT
K
D
VSNKI
L
T
--
NQT
NLTS
TF
YT
GS
IG
HDV
S
T
G
V
E
FTR
E
T
Q
TNYGV
N
PVT
L
PAV
N
I
YHP
DNS
I
HP
G
GL
T
R
NG
------------------
A
N
A
N
GQ
TD
TFA
I
YA
FD
T
LQ
I
T
R
D
F
E
L
N
GG
I
R
L
D
-
-
-----
NYH
TEYDSATAC
G
G
S
G
RGAI
T
CPA
G
V
A
KG
SPVTTVDTAKSGNLVN
W
KA
G
ALY
H
LT
E
N
GN
V
YI
N
YA
VSQQ
P
P
G
G
N
NF
A
LA
Q
S
G
SGNSANRT
DFK
PQ
K
ANT
S
EIGT
KWQ
VL
D
K
R
L
L
LT
A
A
L
FR
T
D
IE
N
EV
E
-
-
-
-
--
-
QN
DD
GT
----
Y
S
Q
Y
GK
K
R
VEG
Y
E
I
S
VAGNIT
P
----
--A
W
QV
I
G
G
Y
---
T
Q
Q
K
A
T
IKNG
K
D
VAQDG
S
S
S
LP
YT
PE
H
AFT
L
WSQY
QA
TD
D
I
S
V
G
AGA
R
Y
I
G
S--
-
---
-
M
H
KG
SDGAV
G
TPAFTE
G
-
Y
WVA
D
A
K
LG
Y
R
V
N
R
NL
D
FQLN
V
Y
NLFD
-
-
-
------
-
-
-
-
---
-
T
D
YVA
SI
N
KSG
Y
R
F
H
PG
EP
RT
FL
L
TA
N
M
HF
fig|656379.3.peg.1641
Escherichia coli FVEC1302 (10-760/760)
RQF
HSLT
FFAG
L
-
CI
G
IT
-
P
V
A
Q
A
LA
A
E
GQANA
DDTLVV
E
A
-
S
T
P
SL
-
Y
AP
QQ
S
ADP
KFSRPVADTTRTM
TV
I
S
EQVI
KD
Q
GAT
NLT
D
AL
K
N
V
PGV
G
A
FFA
GE
N
GNST
T
G
D
-----
A
I
Y
M
RG
ADTS
N
S-
------
IYIDG
-
-
IR
D
I
G
SV
----
--S
RDT
FN
---------
T
E
Q
VEV
IK
GP
S
GT
D
YG
R
SA
P
T
G
S
IN
M
I
S
KQP
RN---
-
--
D
S
G
I
D
A
SA
S
IGSAWFR
R
GT
L
D
V
N
QV
I
-
GD
TTAV
RL
NV
MGE
--
KT
H
D
-
---
--
-
--
-
-----
---------
AGR
DK
I
K
N
E
-----
-
R
YGV
AP
--
S
VAFGL
G
TANRLY
L
N
Y
LHV
TQ
HNTP
D
GGIPTIGLPGYSAPS
AG
T
AA
LN
HS
G
K
V
D
T
HNF
Y
GT
--
-
---
D
SD
Y
D
D
S
T
T
D
T
ATMRF
EH
DINDNTTIRNT
TR
W
SR
VK
QD
YLMT
A
IM
G
-----
G
ASNITQPT
S
-------
D
V
N
S
W
T
W
S
RTA
NT
K
D
VSNKI
L
T
--
NQT
NLTS
TF
YT
GS
IG
HDV
S
T
G
V
E
FTR
E
T
Q
TNYGV
N
PVT
L
PAV
N
I
YHP
DSS
I
HP
G
GL
T
R
NG
------------------
A
N
A
N
GQ
TD
TFA
I
YA
FD
T
LQ
I
T
R
D
F
E
L
N
GG
I
R
L
D
-
-
-----
NYH
TEYDSATAC
G
G
S
G
RGAI
T
CPA
G
M
A
KG
SPVTTVDTAKSGNLVN
W
KA
G
ALY
H
LT
E
N
GN
V
YI
N
YA
VSQQ
P
P
G
G
N
NF
A
LA
Q
S
G
SGNSANRT
DFK
PQ
K
ANT
S
EIGT
KWQ
VL
D
K
R
L
L
LT
A
A
L
FR
T
D
IE
N
EV
E
-
-
-
-
--
-
QN
DD
GT
----
Y
S
Q
Y
GK
K
R
VEG
Y
E
I
S
VAGNIT
P
----
--A
W
QV
I
G
G
Y
---
T
Q
Q
K
A
T
IKNG
K
D
VAQDG
S
S
S
LP
YT
PE
H
AFT
L
WSQY
QA
TD
D
I
S
V
G
AGA
R
Y
I
G
S--
-
---
-
M
H
KG
SDGAV
G
TPAFTE
G
-
Y
WVA
D
A
K
LG
Y
R
V
N
R
NL
D
FQLN
V
Y
NLFD
-
-
-
------
-
-
-
-
---
-
T
D
YVA
SI
N
KSG
Y
R
Y
H
PG
EP
RT
FL
L
TA
N
M
HF
fig|656380.3.peg.1469
Escherichia coli FVEC1412 (10-760/760)
RQF
HSLT
FFAG
L
-
CI
G
IT
-
P
V
A
Q
A
LA
A
E
GQANA
DDTLVV
E
A
-
S
T
P
SL
-
Y
AP
QQ
S
ADP
KFSRPVADTTRTM
TV
I
S
EQVI
KD
Q
GAT
NLT
D
AL
K
N
V
PGV
G
A
FFA
GE
N
GNST
T
G
D
-----
A
I
Y
M
RG
ADTS
N
S-
------
IYIDG
-
-
IR
D
I
G
SV
----
--S
RDT
FN
---------
T
E
Q
VEV
IK
GP
S
GT
D
YG
R
SA
P
T
G
S
IN
M
I
S
KQP
RN---
-
--
D
S
G
I
D
A
SA
S
IGSAWFR
R
GT
L
D
V
N
QV
I
-
GD
TTAV
RL
NV
MGE
--
KT
H
D
-
---
--
-
--
-
-----
---------
AGR
DK
I
K
N
E
-----
-
R
YGV
AP
--
S
VAFGL
G
TANRLY
L
N
Y
LHV
TQ
HNTP
D
GGIPTIGLPGYSAPS
AG
T
AA
LN
HS
G
K
V
D
T
HNF
Y
GT
--
-
---
D
SD
Y
D
D
S
T
T
D
T
ATMRF
EH
DINDNTTIRNT
TR
W
SR
VK
QD
YLMT
A
IM
G
-----
G
ASNITQPT
S
-------
D
V
N
S
W
T
W
S
RTA
NT
K
D
VSNKI
L
T
--
NQT
NLTS
TF
YT
GS
IG
HDV
S
T
G
V
E
FTR
E
T
Q
TNYGV
N
PVT
L
PAV
N
I
YHP
DSS
I
HP
G
GL
T
R
NG
------------------
A
N
A
N
GQ
TD
TFA
I
YA
FD
T
LQ
I
T
R
D
F
E
L
N
GG
I
R
L
D
-
-
-----
NYH
TEYDSATAC
G
G
S
G
RGAI
T
CPA
G
M
A
KG
SPVTTVDTAKSGNLVN
W
KA
G
ALY
H
LT
E
N
GN
V
YI
N
YA
VSQQ
P
P
G
G
N
NF
A
LA
Q
S
G
SGNSANRT
DFK
PQ
K
ANT
S
EIGT
KWQ
VL
D
K
R
L
L
LT
A
A
L
FR
T
D
IE
N
EV
E
-
-
-
-
--
-
QN
DD
GT
----
Y
S
Q
Y
GK
K
R
VEG
Y
E
I
S
VAGNIT
P
----
--A
W
QV
I
G
G
Y
---
T
Q
Q
K
A
T
IKNG
K
D
VAQDG
S
S
S
LP
YT
PE
H
AFT
L
WSQY
QA
TD
D
I
S
V
G
AGA
R
Y
I
G
S--
-
---
-
M
H
KG
SDGAV
G
TPAFTE
G
-
Y
WVA
D
A
K
LG
Y
R
V
N
R
NL
D
FQLN
V
Y
NLFD
-
-
-
------
-
-
-
-
---
-
T
D
YVA
SI
N
KSG
Y
R
Y
H
PG
EP
RT
FL
L
TA
N
M
HF
fig|749549.3.peg.2321
Escherichia coli MS 198-1 (10-760/760)
RQF
HSLT
FFAG
L
-
CI
G
IT
-
P
V
A
Q
A
LA
A
E
GQANA
DDTLVV
E
A
-
S
T
P
SL
-
Y
AP
QQ
S
ADP
KFSRPVADTTRTM
TV
I
S
EQVI
KD
Q
GAT
NLT
D
AL
K
N
V
PGV
G
A
FFA
GE
N
GNST
T
G
D
-----
A
I
Y
M
RG
ADTS
N
S-
------
IYIDG
-
-
IR
D
I
G
SV
----
--S
RDT
FN
---------
T
E
Q
VEV
IK
GP
S
GT
D
YG
R
SA
P
T
G
S
IN
M
I
S
KQP
RN---
-
--
D
S
G
I
D
A
SA
S
IGSAWFR
R
GT
L
D
V
N
QV
I
-
GD
TTAV
RL
NV
MGE
--
KT
H
D
-
---
--
-
--
-
-----
---------
AGR
DK
I
K
N
E
-----
-
R
YGV
AP
--
S
VAFGL
G
TANRLY
L
N
Y
LHV
TQ
HNTP
D
GGIPTIGLPGYSAPS
AG
T
AA
LN
HS
G
K
V
D
T
HNF
Y
GT
--
-
---
D
SD
Y
D
D
S
T
T
D
T
ATMRF
EH
DINDNTTIRNT
TR
W
SR
VK
QD
YLMT
A
IM
G
-----
G
ASNITQPT
S
-------
D
V
N
S
W
T
W
S
RTA
NT
K
D
VSNKI
L
T
--
NQT
NLTS
TF
YT
GS
IG
HDV
S
T
G
V
E
FTR
E
T
Q
TNYGV
N
PVT
L
PAV
N
I
YHP
DSS
I
HP
G
GL
T
R
NG
------------------
A
N
A
N
GQ
TD
TFA
I
YA
FD
T
LQ
I
T
R
D
F
E
L
N
GG
I
R
L
D
-
-
-----
NYH
TEYDSATAC
G
G
S
G
RGAI
T
CPA
G
M
A
KG
SPVTTVDTAKSGNLVN
W
KA
G
ALY
H
LT
E
N
GN
V
YI
N
YA
VSQQ
P
P
G
G
N
NF
A
LA
Q
S
G
SGNSANRT
DFK
PQ
K
ANT
S
EIGT
KWQ
VL
D
K
R
L
L
LT
A
A
L
FR
T
D
IE
N
EV
E
-
-
-
-
--
-
QN
DD
GT
----
Y
S
Q
Y
GK
K
R
VEG
Y
E
I
S
VAGNIT
P
----
--A
W
QV
I
G
G
Y
---
T
Q
Q
K
A
T
IKNG
K
D
VAQDG
S
S
S
LP
YT
PE
H
AFT
L
WSQY
QA
TD
D
I
S
V
G
AGA
R
Y
I
G
S--
-
---
-
M
H
KG
SDGAV
G
TPAFTE
G
-
Y
WVA
D
A
K
LG
Y
R
V
N
R
NL
D
FQLN
V
Y
NLFD
-
-
-
------
-
-
-
-
---
-
T
D
YVA
SI
N
KSG
Y
R
Y
H
PG
EP
RT
FL
L
TA
N
M
HF
fig|656437.3.peg.886
Escherichia coli TA143 (10-760/760)
RQF
HSLT
FFAG
L
-
CI
G
IT
-
P
V
A
Q
A
LA
A
E
GQANA
DDTLVV
E
A
-
S
T
P
SL
-
Y
AP
QQ
S
ADP
KFSRPVADTTRTM
TV
I
S
EQVI
KD
Q
GAT
NLT
D
AL
K
N
V
PGV
G
A
FFA
GE
N
GNST
T
G
D
-----
A
I
Y
M
RG
ADTS
N
S-
------
IYIDG
-
-
IR
D
I
G
SV
----
--S
RDT
FN
---------
T
E
Q
VEV
IK
GP
S
GT
D
YG
R
SA
P
T
G
S
IN
M
I
S
KQP
RN---
-
--
D
S
G
I
D
A
SA
S
IGSAWFR
R
GT
L
D
V
N
QV
I
-
GD
TTAV
RL
NV
MGE
--
KT
H
D
-
---
--
-
--
-
-----
---------
AGR
DK
I
K
N
E
-----
-
R
YGV
AP
--
S
VAFGL
G
TANRLY
L
N
Y
LHV
TQ
HNTP
D
GGIPTIGLPGYSAPS
AG
T
AA
LN
HS
G
K
V
D
T
HNF
Y
GT
--
-
---
D
SD
Y
D
D
S
T
T
D
T
ATMRF
EH
DINDNTTIRNT
TR
W
SR
VK
QD
YLMT
A
IM
G
-----
G
ASNITQPT
S
-------
D
V
N
S
W
T
W
S
RTA
NT
K
D
VSNKI
L
T
--
NQT
NLTS
TF
YT
GS
IG
HDV
S
T
G
V
E
FTR
E
T
Q
TNYGV
N
PVT
L
PAV
N
I
YHP
DSS
I
HP
G
GL
T
R
NG
------------------
A
N
A
N
GQ
TD
TFA
I
YA
FD
T
LQ
I
T
R
D
F
E
L
N
GG
I
R
L
D
-
-
-----
NYH
TEYDSATAC
G
G
S
G
RGAI
T
CPA
G
M
A
KG
SPVTTVDTAKSGNLVN
W
KA
G
ALY
H
LT
E
N
GN
V
YI
N
YA
VSQQ
P
P
G
G
N
NF
A
LA
Q
S
G
SGNSANRT
DFK
PQ
K
ANT
S
EIGT
KWQ
VL
D
K
R
L
L
LT
A
A
L
FR
T
D
IE
N
EV
E
-
-
-
-
--
-
QN
DD
GT
----
Y
S
Q
Y
GK
K
R
VEG
Y
E
I
S
VAGNIT
P
----
--A
W
QV
I
G
G
Y
---
T
Q
Q
K
A
T
IKNG
K
D
VAQDG
S
S
S
LP
YT
PE
H
AFT
L
WSQY
QA
TD
D
I
S
V
G
AGA
R
Y
I
G
S--
-
---
-
M
H
KG
SDGAV
G
TPAFTE
G
-
Y
WVA
D
A
K
LG
Y
R
V
N
R
NL
D
FQLN
V
Y
NLFD
-
-
-
------
-
-
-
-
---
-
T
D
YVA
SI
N
KSG
Y
R
Y
H
PG
EP
RT
FL
L
TA
N
M
HF
fig|585056.7.peg.1144
Escherichia coli UMN026 (10-760/760)
RQF
HSLT
FFAG
L
-
CI
G
IT
-
P
V
A
Q
A
LA
A
E
GQANA
DDTLVV
E
A
-
S
T
P
SL
-
Y
AP
QQ
S
ADP
KFSRPVADTTRTM
TV
I
S
EQVI
KD
Q
GAT
NLT
D
AL
K
N
V
PGV
G
A
FFA
GE
N
GNST
T
G
D
-----
A
I
Y
M
RG
ADTS
N
S-
------
IYIDG
-
-
IR
D
I
G
SV
----
--S
RDT
FN
---------
T
E
Q
VEV
IK
GP
S
GT
D
YG
R
SA
P
T
G
S
IN
M
I
S
KQP
RN---
-
--
D
S
G
I
D
A
SA
S
IGSAWFR
R
GT
L
D
V
N
QV
I
-
GD
TTAV
RL
NV
MGE
--
KT
H
D
-
---
--
-
--
-
-----
---------
AGR
DK
I
K
N
E
-----
-
R
YGV
AP
--
S
VAFGL
G
TANRLY
L
N
Y
LHV
TQ
HNTP
D
GGIPTIGLPGYSAPS
AG
T
AA
LN
HS
G
K
V
D
T
HNF
Y
GT
--
-
---
D
SD
Y
D
D
S
T
T
D
T
ATMRF
EH
DINDNTTIRNT
TR
W
SR
VK
QD
YLMT
A
IM
G
-----
G
ASNITQPT
S
-------
D
V
N
S
W
T
W
S
RTA
NT
K
D
VSNKI
L
T
--
NQT
NLTS
TF
YT
GS
IG
HDV
S
T
G
V
E
FTR
E
T
Q
TNYGV
N
PVT
L
PAV
N
I
YHP
DSS
I
HP
G
GL
T
R
NG
------------------
A
N
A
N
GQ
TD
TFA
I
YA
FD
T
LQ
I
T
R
D
F
E
L
N
GG
I
R
L
D
-
-
-----
NYH
TEYDSATAC
G
G
S
G
RGAI
T
CPA
G
M
A
KG
SPVTTVDTAKSGNLVN
W
KA
G
ALY
H
LT
E
N
GN
V
YI
N
YA
VSQQ
P
P
G
G
N
NF
A
LA
Q
S
G
SGNSANRT
DFK
PQ
K
ANT
S
EIGT
KWQ
VL
D
K
R
L
L
LT
A
A
L
FR
T
D
IE
N
EV
E
-
-
-
-
--
-
QN
DD
GT
----
Y
S
Q
Y
GK
K
R
VEG
Y
E
I
S
VAGNIT
P
----
--A
W
QV
I
G
G
Y
---
T
Q
Q
K
A
T
IKNG
K
D
VAQDG
S
S
S
LP
YT
PE
H
AFT
L
WSQY
QA
TD
D
I
S
V
G
AGA
R
Y
I
G
S--
-
---
-
M
H
KG
SDGAV
G
TPAFTE
G
-
Y
WVA
D
A
K
LG
Y
R
V
N
R
NL
D
FQLN
V
Y
NLFD
-
-
-
------
-
-
-
-
---
-
T
D
YVA
SI
N
KSG
Y
R
Y
H
PG
EP
RT
FL
L
TA
N
M
HF
fig|340197.3.peg.3834
Escherichia coli F11 (10-760/760)
RQF
HSLT
FFAG
L
-
CI
G
IT
-
P
V
A
Q
A
LA
A
E
GQANA
DDTLVV
E
A
-
S
T
P
SL
-
Y
AP
QQ
S
ADP
KFSRPVADTTRTM
TV
I
S
EQVI
KD
Q
GAT
NLT
D
AL
K
N
V
PGV
G
A
FFA
GE
N
GNST
T
G
D
-----
A
I
Y
M
RG
ADTS
N
S-
------
IYIDG
-
-
IR
D
I
G
SV
----
--S
RDT
FN
---------
T
E
Q
VEV
IK
GP
S
GT
D
YG
R
SA
P
T
G
S
IN
M
I
S
KQP
RN---
-
--
D
S
G
I
D
A
SA
S
IGSAWFR
R
GT
L
D
V
N
QV
I
-
GD
TTAV
RL
NV
MGE
--
KT
H
D
-
---
--
-
--
-
-----
---------
AGR
DK
V
K
N
E
-----
-
R
YGV
AP
--
S
VAFGL
G
TANRLY
L
N
Y
LHV
TQ
HNTP
D
GGIPTIGLPGYSAPS
AG
T
AA
LN
HS
G
K
V
D
T
HNF
Y
GT
--
-
---
D
SD
Y
D
D
S
T
T
D
T
ATMRF
EH
DINDNTTIRNT
TR
W
SR
VK
QD
YLMT
A
IM
G
-----
G
ASNITQPT
S
-------
D
V
N
S
W
T
W
S
RTA
NT
K
D
VSNKI
L
T
--
NQT
NLTS
TF
YT
G
A
IG
HDV
S
T
G
V
E
FTR
E
T
Q
TNYGV
N
PVT
L
PAV
N
I
YHP
DSS
I
HP
G
GL
T
R
NG
------------------
A
N
A
N
GQ
TD
TFA
I
YA
FD
T
LQ
I
T
R
D
F
E
L
N
GG
I
R
L
D
-
-
-----
NYH
TEYDSATAC
G
G
S
G
RGAI
T
CPA
G
V
A
KG
SPVTTVDTAKSGNLVN
W
KA
G
ALY
H
LT
E
N
GN
V
YI
N
YA
VSQQ
P
P
G
G
N
NF
A
LA
Q
S
G
SGNSANRT
DFK
PQ
K
ANT
S
EIGT
KWQ
VL
D
K
R
L
L
LT
A
A
L
FR
T
D
IE
N
EV
E
-
-
-
-
--
-
QN
DD
GT
----
Y
S
Q
Y
GK
K
R
VEG
Y
E
I
S
VAGNIT
P
----
--A
W
QM
I
G
G
Y
---
T
Q
Q
K
A
T
IKNG
K
D
VAQDG
S
S
S
LP
YT
PE
H
AFT
L
WSQY
QA
TD
D
I
S
V
G
AGA
R
Y
I
G
S--
-
---
-
M
H
KG
SDGAV
G
TPAFTE
D
-
Y
WVA
D
A
K
LG
Y
R
V
N
R
NL
D
FQLN
V
Y
NLFD
-
-
-
------
-
-
-
-
---
-
T
D
YVA
SI
N
KSG
Y
R
Y
H
PG
EP
RT
FL
L
TA
N
M
HF
fig|340197.5.peg.4010
Escherichia coli F11 (10-760/760)
RQF
HSLT
FFAG
L
-
CI
G
IT
-
P
V
A
Q
A
LA
A
E
GQANA
DDTLVV
E
A
-
S
T
P
SL
-
Y
AP
QQ
S
ADP
KFSRPVADTTRTM
TV
I
S
EQVI
KD
Q
GAT
NLT
D
AL
K
N
V
PGV
G
A
FFA
GE
N
GNST
T
G
D
-----
A
I
Y
M
RG
ADTS
N
S-
------
IYIDG
-
-
IR
D
I
G
SV
----
--S
RDT
FN
---------
T
E
Q
VEV
IK
GP
S
GT
D
YG
R
SA
P
T
G
S
IN
M
I
S
KQP
RN---
-
--
D
S
G
I
D
A
SA
S
IGSAWFR
R
GT
L
D
V
N
QV
I
-
GD
TTAV
RL
NV
MGE
--
KT
H
D
-
---
--
-
--
-
-----
---------
AGR
DK
V
K
N
E
-----
-
R
YGV
AP
--
S
VAFGL
G
TANRLY
L
N
Y
LHV
TQ
HNTP
D
GGIPTIGLPGYSAPS
AG
T
AA
LN
HS
G
K
V
D
T
HNF
Y
GT
--
-
---
D
SD
Y
D
D
S
T
T
D
T
ATMRF
EH
DINDNTTIRNT
TR
W
SR
VK
QD
YLMT
A
IM
G
-----
G
ASNITQPT
S
-------
D
V
N
S
W
T
W
S
RTA
NT
K
D
VSNKI
L
T
--
NQT
NLTS
TF
YT
G
A
IG
HDV
S
T
G
V
E
FTR
E
T
Q
TNYGV
N
PVT
L
PAV
N
I
YHP
DSS
I
HP
G
GL
T
R
NG
------------------
A
N
A
N
GQ
TD
TFA
I
YA
FD
T
LQ
I
T
R
D
F
E
L
N
GG
I
R
L
D
-
-
-----
NYH
TEYDSATAC
G
G
S
G
RGAI
T
CPA
G
V
A
KG
SPVTTVDTAKSGNLVN
W
KA
G
ALY
H
LT
E
N
GN
V
YI
N
YA
VSQQ
P
P
G
G
N
NF
A
LA
Q
S
G
SGNSANRT
DFK
PQ
K
ANT
S
EIGT
KWQ
VL
D
K
R
L
L
LT
A
A
L
FR
T
D
IE
N
EV
E
-
-
-
-
--
-
QN
DD
GT
----
Y
S
Q
Y
GK
K
R
VEG
Y
E
I
S
VAGNIT
P
----
--A
W
QM
I
G
G
Y
---
T
Q
Q
K
A
T
IKNG
K
D
VAQDG
S
S
S
LP
YT
PE
H
AFT
L
WSQY
QA
TD
D
I
S
V
G
AGA
R
Y
I
G
S--
-
---
-
M
H
KG
SDGAV
G
TPAFTE
D
-
Y
WVA
D
A
K
LG
Y
R
V
N
R
NL
D
FQLN
V
Y
NLFD
-
-
-
------
-
-
-
-
---
-
T
D
YVA
SI
N
KSG
Y
R
Y
H
PG
EP
RT
FL
L
TA
N
M
HF
fig|749550.3.peg.3764
Escherichia coli MS 200-1 (10-760/760)
RQF
HSLT
FFAG
L
-
CI
G
IT
-
P
V
A
Q
A
LA
A
E
GQANA
DDTLVV
E
A
-
S
T
P
SL
-
Y
AP
QQ
S
ADP
KFSRPVADTTRTM
TV
I
S
EQVI
KD
Q
GAT
NLT
D
AL
K
N
V
PGV
G
A
FFA
GE
N
GNST
T
G
D
-----
A
I
Y
M
RG
ADTS
N
S-
------
IYIDG
-
-
IR
D
I
G
SV
----
--S
RDT
FN
---------
T
E
Q
VEV
IK
GP
S
GT
D
YG
R
SA
P
T
G
S
IN
M
I
S
KQP
RN---
-
--
D
S
G
I
D
A
SA
S
IGSAWFR
R
GT
L
D
V
N
QV
I
-
GD
TTAV
RL
NV
MGE
--
KT
H
D
-
---
--
-
--
-
-----
---------
AGR
DK
V
K
N
E
-----
-
R
YGV
AP
--
S
VAFGL
G
TANRLY
L
N
Y
LHV
TQ
HNTP
D
GGIPTIGLPGYSAPS
AG
T
AA
LN
HS
G
K
V
D
T
HNF
Y
GT
--
-
---
D
SD
Y
D
D
S
T
T
D
T
ATMRF
EH
DINDNTTIRNT
TR
W
SR
VK
QD
YLMT
A
IM
G
-----
G
ASNITQPT
S
-------
D
V
N
S
W
T
W
S
RTA
NT
K
D
VSNKI
L
T
--
NQT
NLTS
TF
YT
G
A
IG
HDV
S
T
G
V
E
FTR
E
T
Q
TNYGV
N
PVT
L
PAV
N
I
YHP
DSS
I
HP
G
GL
T
R
NG
------------------
A
N
A
N
GQ
TD
TFA
I
YA
FD
T
LQ
I
T
R
D
F
E
L
N
GG
I
R
L
D
-
-
-----
NYH
TEYDSATAC
G
G
S
G
RGAI
T
CPA
G
V
A
KG
SPVTTVDTAKSGNLVN
W
KA
G
ALY
H
LT
E
N
GN
V
YI
N
YA
VSQQ
P
P
G
G
N
NF
A
LA
Q
S
G
SGNSANRT
DFK
PQ
K
ANT
S
EIGT
KWQ
VL
D
K
R
L
L
LT
A
A
L
FR
T
D
IE
N
EV
E
-
-
-
-
--
-
QN
DD
GT
----
Y
S
Q
Y
GK
K
R
VEG
Y
E
I
S
VAGNIT
P
----
--A
W
QM
I
G
G
Y
---
T
Q
Q
K
A
T
IKNG
K
D
VAQDG
S
S
S
LP
YT
PE
H
AFT
L
WSQY
QA
TD
D
I
S
V
G
AGA
R
Y
I
G
S--
-
---
-
M
H
KG
SDGAV
G
TPAFTE
D
-
Y
WVA
D
A
K
LG
Y
R
V
N
R
NL
D
FQLN
V
Y
NLFD
-
-
-
------
-
-
-
-
---
-
T
D
YVA
SI
N
KSG
Y
R
Y
H
PG
EP
RT
FL
L
TA
N
M
HF
fig|199310.1.peg.863
Escherichia coli CFT073 (10-760/760)
RQF
HSLT
FFAG
L
-
CI
G
IT
-
P
V
A
Q
A
LA
A
E
GQANA
DDTLVV
E
A
-
S
T
P
SL
-
Y
AP
QQ
S
ADP
KFSRPVADTTRTM
TV
I
S
EQVI
KD
Q
GAT
NLT
D
AL
K
N
V
PGV
G
A
FFA
GE
N
GNST
T
G
D
-----
A
I
Y
M
RG
ADTS
N
S-
------
IYIDG
-
-
IR
D
I
G
SV
----
--S
RDT
FN
---------
T
E
Q
VEV
IK
GP
S
GT
D
YG
R
SA
P
T
G
S
IN
M
I
S
KQP
RN---
-
--
D
S
G
I
D
A
SA
S
IGSAWFR
R
GT
L
D
V
N
QV
I
-
GD
TTAV
RL
NV
MGE
--
KT
H
D
-
---
--
-
--
-
-----
---------
AGR
DK
V
K
N
E
-----
-
R
YGV
AP
--
S
VVFGL
G
TANRLY
L
N
Y
LHV
TQ
HNTP
D
GGIPTIGLPGYSAPS
AG
T
AA
LN
HS
G
K
V
D
T
HNF
Y
GT
--
-
---
D
SD
Y
D
D
S
T
T
D
T
ATMRF
EH
DINDNTTIRNT
TR
W
SR
VK
QD
YLMT
A
IM
G
-----
G
ASNITQPT
S
-------
D
V
N
S
W
T
W
S
RTA
NT
K
D
VSNKI
L
T
--
NQT
NLTS
TF
YT
G
A
IG
HD
L
S
T
G
V
E
FTR
E
T
Q
TNYGV
N
PVT
L
PAV
N
I
YHP
DSS
I
HP
G
GL
T
R
NG
------------------
A
N
A
N
GQ
TD
TFA
I
YA
FD
T
LQ
I
T
R
D
F
E
L
N
GG
I
R
L
D
-
-
-----
NYH
TEYDSATAC
G
G
S
G
RGAI
T
CPA
G
V
A
KG
SPVTTVDTAKSGNLVN
W
KA
G
ALY
H
LT
E
N
GN
V
YI
N
YA
VSQQ
P
P
G
G
N
NF
A
LA
Q
S
G
SGNSANRT
DFK
PQ
K
ANT
S
EIGT
KWQ
VL
D
K
R
L
L
LT
A
A
L
FR
T
D
IE
N
EV
E
-
-
-
-
--
-
QN
DD
GT
----
Y
S
Q
Y
GK
K
R
VEG
Y
E
I
S
VAGNIT
P
----
--A
W
QM
I
G
G
Y
---
T
Q
Q
K
A
T
IKNG
K
D
VAQDG
S
S
S
LP
YT
PE
H
AFT
L
WSQY
QA
TD
D
I
S
V
G
AGA
R
Y
I
G
S--
-
---
-
M
H
KG
SDGAV
G
TPAFTE
G
-
Y
WVA
D
A
K
LG
Y
R
V
N
R
NL
D
FQLN
V
Y
NLFD
-
-
-
------
-
-
-
-
---
-
T
D
YVA
SI
N
KSG
Y
R
Y
H
PG
EP
RT
FL
L
TA
N
M
HF
fig|199310.4.peg.844
Escherichia coli CFT073 (10-760/760)
RQF
HSLT
FFAG
L
-
CI
G
IT
-
P
V
A
Q
A
LA
A
E
GQANA
DDTLVV
E
A
-
S
T
P
SL
-
Y
AP
QQ
S
ADP
KFSRPVADTTRTM
TV
I
S
EQVI
KD
Q
GAT
NLT
D
AL
K
N
V
PGV
G
A
FFA
GE
N
GNST
T
G
D
-----
A
I
Y
M
RG
ADTS
N
S-
------
IYIDG
-
-
IR
D
I
G
SV
----
--S
RDT
FN
---------
T
E
Q
VEV
IK
GP
S
GT
D
YG
R
SA
P
T
G
S
IN
M
I
S
KQP
RN---
-
--
D
S
G
I
D
A
SA
S
IGSAWFR
R
GT
L
D
V
N
QV
I
-
GD
TTAV
RL
NV
MGE
--
KT
H
D
-
---
--
-
--
-
-----
---------
AGR
DK
V
K
N
E
-----
-
R
YGV
AP
--
S
VVFGL
G
TANRLY
L
N
Y
LHV
TQ
HNTP
D
GGIPTIGLPGYSAPS
AG
T
AA
LN
HS
G
K
V
D
T
HNF
Y
GT
--
-
---
D
SD
Y
D
D
S
T
T
D
T
ATMRF
EH
DINDNTTIRNT
TR
W
SR
VK
QD
YLMT
A
IM
G
-----
G
ASNITQPT
S
-------
D
V
N
S
W
T
W
S
RTA
NT
K
D
VSNKI
L
T
--
NQT
NLTS
TF
YT
G
A
IG
HD
L
S
T
G
V
E
FTR
E
T
Q
TNYGV
N
PVT
L
PAV
N
I
YHP
DSS
I
HP
G
GL
T
R
NG
------------------
A
N
A
N
GQ
TD
TFA
I
YA
FD
T
LQ
I
T
R
D
F
E
L
N
GG
I
R
L
D
-
-
-----
NYH
TEYDSATAC
G
G
S
G
RGAI
T
CPA
G
V
A
KG
SPVTTVDTAKSGNLVN
W
KA
G
ALY
H
LT
E
N
GN
V
YI
N
YA
VSQQ
P
P
G
G
N
NF
A
LA
Q
S
G
SGNSANRT
DFK
PQ
K
ANT
S
EIGT
KWQ
VL
D
K
R
L
L
LT
A
A
L
FR
T
D
IE
N
EV
E
-
-
-
-
--
-
QN
DD
GT
----
Y
S
Q
Y
GK
K
R
VEG
Y
E
I
S
VAGNIT
P
----
--A
W
QM
I
G
G
Y
---
T
Q
Q
K
A
T
IKNG
K
D
VAQDG
S
S
S
LP
YT
PE
H
AFT
L
WSQY
QA
TD
D
I
S
V
G
AGA
R
Y
I
G
S--
-
---
-
M
H
KG
SDGAV
G
TPAFTE
G
-
Y
WVA
D
A
K
LG
Y
R
V
N
R
NL
D
FQLN
V
Y
NLFD
-
-
-
------
-
-
-
-
---
-
T
D
YVA
SI
N
KSG
Y
R
Y
H
PG
EP
RT
FL
L
TA
N
M
HF
fig|550677.3.peg.2074
Escherichia coli B354 (10-760/760)
RQF
HSLT
FFAG
L
-
CI
G
IT
-
P
V
A
Q
A
LA
A
E
GQANA
DDTLVV
E
A
-
S
T
P
SL
-
Y
AP
QQ
S
ADP
KFSRPVADTTRTM
TV
I
S
EQVI
KD
Q
GAT
NLT
D
AL
K
N
V
PGV
G
A
FFA
GE
N
GNST
T
G
D
-----
A
I
Y
M
RG
ADTS
N
S-
------
IYIDG
-
-
IR
D
I
G
SV
----
--S
RDT
FN
---------
T
E
Q
VEV
IK
GP
S
GT
D
YG
R
SA
P
T
G
S
IN
M
I
S
KQP
RN---
-
--
D
S
G
I
D
A
SA
S
IGSAWFR
R
GT
L
D
V
N
Q
A
I
-
GD
TTAV
RL
NV
MGE
--
KT
H
D
-
---
--
-
--
-
-----
---------
AGR
DK
I
K
N
E
-----
-
R
YGV
AP
--
S
VAFGL
G
TANRLY
L
N
Y
LHV
TQ
HNTP
D
GGIPTIGLPGYSAPS
AG
T
AA
LN
HS
G
K
V
D
T
HNF
Y
GT
--
-
---
D
SD
Y
D
D
S
T
T
D
T
ATMRF
EH
DINDNTTIRNT
TR
W
SR
VK
QD
YLMT
A
IM
G
-----
G
ASNITQPT
S
-------
D
V
N
S
W
T
W
S
RTA
NT
K
D
VSNKI
L
T
--
NQT
NLTS
TF
YT
GS
IG
HDV
S
T
G
V
E
FTR
E
T
Q
TNYGV
N
PVT
L
PAV
N
I
YHP
DNS
I
HP
G
GL
T
R
NG
------------------
A
N
A
N
GQ
TD
TFA
I
YA
FD
T
LQ
I
T
R
D
F
E
L
N
GG
I
R
L
D
-
-
-----
NYH
TEYDSATAC
G
G
S
G
RGAI
T
CPA
G
V
A
KG
SPVTTVDTAKSGNLVN
W
KA
G
ALY
H
LT
E
N
GN
V
YI
N
YA
VSQQ
P
P
G
G
N
NF
A
LA
Q
S
G
SGNSANRT
DFK
PQ
K
ANT
S
EIGT
KWQ
VL
D
K
R
L
L
LT
A
A
L
FR
T
D
IE
N
EV
E
-
-
-
-
--
-
QN
DD
GT
----
Y
S
Q
Y
GK
K
R
VEG
Y
E
I
S
VAGNIT
P
----
--A
W
QV
I
G
G
Y
---
T
Q
Q
K
A
T
IKNG
K
D
VAQDG
S
S
S
LP
YT
PE
H
AFT
L
WSQY
QA
TD
D
I
S
V
G
AGA
R
Y
I
G
S--
-
---
-
M
H
KG
SDGAV
G
TPAFTE
G
-
Y
WVA
D
T
K
LG
Y
R
V
N
R
NL
D
FQLN
V
Y
NLFD
-
-
-
------
-
-
-
-
---
-
T
D
YVA
SI
N
KSG
Y
R
Y
H
PG
EP
RT
FL
L
TA
N
M
HF
fig|405955.13.peg.764
Escherichia coli APEC O1 (10-760/760)
RQF
HSLT
FFAG
L
-
CI
G
IT
-
P
V
A
Q
A
LA
A
E
GQANA
DDTLVV
E
A
-
S
T
P
SL
-
Y
AP
QQ
S
ADP
KFSRPVADTTRTM
TV
I
S
EQVI
KD
Q
GAT
NLT
D
AL
K
N
V
PGV
G
A
FFA
GE
N
GNST
T
G
D
-----
A
I
Y
M
RG
ADTS
N
S-
------
IYIDG
-
-
IR
D
I
G
SV
----
--S
RDT
FN
---------
T
E
Q
VEV
IK
GP
S
GT
D
YG
R
SA
P
T
G
S
IN
M
I
S
KQP
RN---
-
--
D
S
G
I
D
A
SA
S
IGSAWFR
R
GT
L
D
V
N
QV
I
-
GD
TTAV
RL
NV
MGE
--
KT
H
D
-
---
--
-
--
-
-----
---------
AGR
DK
V
K
N
E
-----
-
R
YGV
AP
--
S
VAFGL
G
TANRLY
L
N
Y
LHV
TQ
HNTP
D
GGIPTIGLPGYSAPS
AG
T
AA
LN
HS
G
K
V
D
T
HNF
Y
GT
--
-
---
D
SD
Y
D
D
S
T
T
D
T
ATMRF
EH
DINDNTTIRNT
TR
W
SR
VK
QD
YLMT
A
IM
G
-----
G
ASNITQPT
S
-------
D
V
N
S
W
T
W
S
RTA
NT
K
D
VSNKI
L
T
--
NQT
NLTS
TF
YT
G
A
IG
HDV
S
T
G
V
E
FTR
E
T
Q
TNYGV
N
PVT
L
PAV
N
I
YHP
DSS
I
HP
S
GL
T
R
NG
------------------
A
N
A
N
GQ
TD
TFA
I
YA
FD
T
LQ
I
T
R
D
F
E
L
N
GG
I
R
L
D
-
-
-----
NYH
TEYDSATAC
G
G
S
G
RGAI
T
CPA
G
V
A
KG
SPVTTVDTAKSGNLVN
W
KA
G
ALY
H
LT
E
N
GN
I
YI
N
YA
VSQQ
P
P
G
G
N
NF
A
LA
Q
S
G
SGNSANRT
DFK
PQ
K
ANT
S
EIGT
KWQ
VL
D
K
R
L
L
LT
A
A
L
FR
T
D
IE
N
EV
E
-
-
-
-
--
-
QN
DD
GT
----
Y
S
Q
Y
GK
K
R
VEG
Y
E
I
S
VAGNIT
P
----
--A
W
QM
I
G
G
Y
---
T
Q
Q
K
A
T
IKNG
K
D
VAQDG
S
S
S
LP
YT
PE
H
AFT
L
WSQY
QA
TD
D
I
S
V
G
AGA
R
Y
I
G
S--
-
---
-
M
H
KG
SDGAV
G
TPAFTE
G
-
Y
WVA
D
A
K
LG
Y
R
V
N
R
NL
D
FQLN
V
Y
NLFD
-
-
-
------
-
-
-
-
---
-
T
D
YVA
SI
N
KSG
Y
R
Y
H
PG
EP
RT
FL
L
TA
N
M
HF
fig|405955.9.peg.640
Escherichia coli APEC O1 (10-760/760)
RQF
HSLT
FFAG
L
-
CI
G
IT
-
P
V
A
Q
A
LA
A
E
GQANA
DDTLVV
E
A
-
S
T
P
SL
-
Y
AP
QQ
S
ADP
KFSRPVADTTRTM
TV
I
S
EQVI
KD
Q
GAT
NLT
D
AL
K
N
V
PGV
G
A
FFA
GE
N
GNST
T
G
D
-----
A
I
Y
M
RG
ADTS
N
S-
------
IYIDG
-
-
IR
D
I
G
SV
----
--S
RDT
FN
---------
T
E
Q
VEV
IK
GP
S
GT
D
YG
R
SA
P
T
G
S
IN
M
I
S
KQP
RN---
-
--
D
S
G
I
D
A
SA
S
IGSAWFR
R
GT
L
D
V
N
QV
I
-
GD
TTAV
RL
NV
MGE
--
KT
H
D
-
---
--
-
--
-
-----
---------
AGR
DK
V
K
N
E
-----
-
R
YGV
AP
--
S
VAFGL
G
TANRLY
L
N
Y
LHV
TQ
HNTP
D
GGIPTIGLPGYSAPS
AG
T
AA
LN
HS
G
K
V
D
T
HNF
Y
GT
--
-
---
D
SD
Y
D
D
S
T
T
D
T
ATMRF
EH
DINDNTTIRNT
TR
W
SR
VK
QD
YLMT
A
IM
G
-----
G
ASNITQPT
S
-------
D
V
N
S
W
T
W
S
RTA
NT
K
D
VSNKI
L
T
--
NQT
NLTS
TF
YT
G
A
IG
HDV
S
T
G
V
E
FTR
E
T
Q
TNYGV
N
PVT
L
PAV
N
I
YHP
DSS
I
HP
S
GL
T
R
NG
------------------
A
N
A
N
GQ
TD
TFA
I
YA
FD
T
LQ
I
T
R
D
F
E
L
N
GG
I
R
L
D
-
-
-----
NYH
TEYDSATAC
G
G
S
G
RGAI
T
CPA
G
V
A
KG
SPVTTVDTAKSGNLVN
W
KA
G
ALY
H
LT
E
N
GN
I
YI
N
YA
VSQQ
P
P
G
G
N
NF
A
LA
Q
S
G
SGNSANRT
DFK
PQ
K
ANT
S
EIGT
KWQ
VL
D
K
R
L
L
LT
A
A
L
FR
T
D
IE
N
EV
E
-
-
-
-
--
-
QN
DD
GT
----
Y
S
Q
Y
GK
K
R
VEG
Y
E
I
S
VAGNIT
P
----
--A
W
QM
I
G
G
Y
---
T
Q
Q
K
A
T
IKNG
K
D
VAQDG
S
S
S
LP
YT
PE
H
AFT
L
WSQY
QA
TD
D
I
S
V
G
AGA
R
Y
I
G
S--
-
---
-
M
H
KG
SDGAV
G
TPAFTE
G
-
Y
WVA
D
A
K
LG
Y
R
V
N
R
NL
D
FQLN
V
Y
NLFD
-
-
-
------
-
-
-
-
---
-
T
D
YVA
SI
N
KSG
Y
R
Y
H
PG
EP
RT
FL
L
TA
N
M
HF
fig|562.371.peg.2247
Escherichia coli 1044A (10-760/760)
RQF
HSLT
FFAG
L
-
CI
G
IT
-
P
V
A
Q
A
LA
A
E
GQTNA
DDTLVV
E
A
-
S
T
P
SL
-
Y
AP
QQ
S
ADP
KFSRPVADTTRTM
TV
I
S
EQVI
KD
Q
GAT
NLT
D
AL
K
N
V
PGV
G
A
FFA
GE
N
GNST
T
G
D
-----
A
I
Y
M
RG
ADTS
N
S-
------
IYIDG
-
-
IR
D
I
G
SV
----
--S
RDT
FN
---------
T
E
Q
VEV
IK
GP
S
GT
D
YG
R
SA
P
T
G
S
IN
M
I
S
KQP
RN---
-
--
D
S
G
I
D
A
SA
S
IGSAWFR
R
GT
L
D
V
N
QV
I
-
GD
TTAV
RL
NV
MGE
--
KT
H
D
-
---
--
-
--
-
-----
---------
AGR
DK
V
K
N
E
-----
-
R
YGV
AP
--
S
IAFGL
G
TANRLY
L
N
Y
LHV
TQ
HNTP
D
GGIPTIGLPGYSAPS
AG
T
AT
LN
HS
G
K
V
D
T
HNF
Y
GT
--
-
---
D
SD
Y
D
D
S
T
T
D
T
ATMRF
EH
DINDNTTIRNT
TR
W
SR
VK
QD
YLMT
A
IM
G
-----
G
ASNITQPT
S
-------
D
V
N
S
W
T
W
S
RTA
NT
K
D
VSNKI
L
T
--
NQT
NLTS
TF
YT
A
S
IG
HDV
S
T
G
V
E
FTR
E
T
Q
TNYGV
N
PVT
L
PAV
N
I
YHP
DSS
I
HP
G
GL
T
R
NG
------------------
A
N
A
N
GQ
TD
TFA
I
YA
FD
T
LQ
I
T
R
D
F
E
L
N
GG
I
R
L
D
-
-
-----
NYH
TEYDSATAC
G
G
S
G
RGAI
T
CPA
G
V
A
KG
SPVTTVDTAKSGNLVN
W
KA
G
ALY
H
LT
E
N
GN
V
YI
N
YA
VSQQ
P
P
G
G
N
NF
A
LA
Q
S
G
SGNSANRT
DFK
PQ
K
ANT
S
EIGT
KWQ
VL
D
K
R
L
L
LT
A
A
L
FR
T
D
IE
N
EV
E
-
-
-
-
--
-
QN
DD
GT
----
Y
S
Q
Y
GK
K
R
VEG
Y
E
I
S
VAGNIT
P
----
--A
W
QV
I
G
G
Y
---
T
Q
Q
K
A
T
IKNG
K
D
VAQDG
S
S
S
LP
YT
PE
H
AFT
L
WSQY
QA
TD
D
I
S
V
G
AGA
R
Y
I
G
S--
-
---
-
M
H
KG
SDGAV
G
TPAFTE
G
-
Y
WVA
D
A
K
LG
Y
R
V
N
R
NL
D
FQLN
V
Y
NLFD
-
-
-
------
-
-
-
-
---
-
T
D
YVA
SI
N
KSG
Y
R
Y
H
PG
EP
RT
FL
L
TA
N
M
HF
fig|562.373.peg.1230
Escherichia coli 1125A (10-760/760)
RQF
HSLT
FFAG
L
-
CI
G
IT
-
P
V
A
Q
A
LA
A
E
GQTNA
DDTLVV
E
A
-
S
T
P
SL
-
Y
AP
QQ
S
ADP
KFSRPVADTTRTM
TV
I
S
EQVI
KD
Q
GAT
NLT
D
AL
K
N
V
PGV
G
A
FFA
GE
N
GNST
T
G
D
-----
A
I
Y
M
RG
ADTS
N
S-
------
IYIDG
-
-
IR
D
I
G
SV
----
--S
RDT
FN
---------
T
E
Q
VEV
IK
GP
S
GT
D
YG
R
SA
P
T
G
S
IN
M
I
S
KQP
RN---
-
--
D
S
G
I
D
A
SA
S
IGSAWFR
R
GT
L
D
V
N
QV
I
-
GD
TTAV
RL
NV
MGE
--
KT
H
D
-
---
--
-
--
-
-----
---------
AGR
DK
V
K
N
E
-----
-
R
YGV
AP
--
S
IAFGL
G
TANRLY
L
N
Y
LHV
TQ
HNTP
D
GGIPTIGLPGYSAPS
AG
T
AT
LN
HS
G
K
V
D
T
HNF
Y
GT
--
-
---
D
SD
Y
D
D
S
T
T
D
T
ATMRF
EH
DINDNTTIRNT
TR
W
SR
VK
QD
YLMT
A
IM
G
-----
G
ASNITQPT
S
-------
D
V
N
S
W
T
W
S
RTA
NT
K
D
VSNKI
L
T
--
NQT
NLTS
TF
YT
A
S
IG
HDV
S
T
G
V
E
FTR
E
T
Q
TNYGV
N
PVT
L
PAV
N
I
YHP
DSS
I
HP
G
GL
T
R
NG
------------------
A
N
A
N
GQ
TD
TFA
I
YA
FD
T
LQ
I
T
R
D
F
E
L
N
GG
I
R
L
D
-
-
-----
NYH
TEYDSATAC
G
G
S
G
RGAI
T
CPA
G
V
A
KG
SPVTTVDTAKSGNLVN
W
KA
G
ALY
H
LT
E
N
GN
V
YI
N
YA
VSQQ
P
P
G
G
N
NF
A
LA
Q
S
G
SGNSANRT
DFK
PQ
K
ANT
S
EIGT
KWQ
VL
D
K
R
L
L
LT
A
A
L
FR
T
D
IE
N
EV
E
-
-
-
-
--
-
QN
DD
GT
----
Y
S
Q
Y
GK
K
R
VEG
Y
E
I
S
VAGNIT
P
----
--A
W
QV
I
G
G
Y
---
T
Q
Q
K
A
T
IKNG
K
D
VAQDG
S
S
S
LP
YT
PE
H
AFT
L
WSQY
QA
TD
D
I
S
V
G
AGA
R
Y
I
G
S--
-
---
-
M
H
KG
SDGAV
G
TPAFTE
G
-
Y
WVA
D
A
K
LG
Y
R
V
N
R
NL
D
FQLN
V
Y
NLFD
-
-
-
------
-
-
-
-
---
-
T
D
YVA
SI
N
KSG
Y
R
Y
H
PG
EP
RT
FL
L
TA
N
M
HF
fig|83334.1.peg.953
Escherichia coli O157:H7 (10-760/760)
RQF
HSLT
FFAG
L
-
CI
G
IT
-
P
V
A
Q
A
LA
A
E
GQTNA
DDTLVV
E
A
-
S
T
P
SL
-
Y
AP
QQ
S
ADP
KFSRPVADTTRTM
TV
I
S
EQVI
KD
Q
GAT
NLT
D
AL
K
N
V
PGV
G
A
FFA
GE
N
GNST
T
G
D
-----
A
I
Y
M
RG
ADTS
N
S-
------
IYIDG
-
-
IR
D
I
G
SV
----
--S
RDT
FN
---------
T
E
Q
VEV
IK
GP
S
GT
D
YG
R
SA
P
T
G
S
IN
M
I
S
KQP
RN---
-
--
D
S
G
I
D
A
SA
S
IGSAWFR
R
GT
L
D
V
N
QV
I
-
GD
TTAV
RL
NV
MGE
--
KT
H
D
-
---
--
-
--
-
-----
---------
AGR
DK
V
K
N
E
-----
-
R
YGV
AP
--
S
IAFGL
G
TANRLY
L
N
Y
LHV
TQ
HNTP
D
GGIPTIGLPGYSAPS
AG
T
AT
LN
HS
G
K
V
D
T
HNF
Y
GT
--
-
---
D
SD
Y
D
D
S
T
T
D
T
ATMRF
EH
DINDNTTIRNT
TR
W
SR
VK
QD
YLMT
A
IM
G
-----
G
ASNITQPT
S
-------
D
V
N
S
W
T
W
S
RTA
NT
K
D
VSNKI
L
T
--
NQT
NLTS
TF
YT
A
S
IG
HDV
S
T
G
V
E
FTR
E
T
Q
TNYGV
N
PVT
L
PAV
N
I
YHP
DSS
I
HP
G
GL
T
R
NG
------------------
A
N
A
N
GQ
TD
TFA
I
YA
FD
T
LQ
I
T
R
D
F
E
L
N
GG
I
R
L
D
-
-
-----
NYH
TEYDSATAC
G
G
S
G
RGAI
T
CPA
G
V
A
KG
SPVTTVDTAKSGNLVN
W
KA
G
ALY
H
LT
E
N
GN
V
YI
N
YA
VSQQ
P
P
G
G
N
NF
A
LA
Q
S
G
SGNSANRT
DFK
PQ
K
ANT
S
EIGT
KWQ
VL
D
K
R
L
L
LT
A
A
L
FR
T
D
IE
N
EV
E
-
-
-
-
--
-
QN
DD
GT
----
Y
S
Q
Y
GK
K
R
VEG
Y
E
I
S
VAGNIT
P
----
--A
W
QV
I
G
G
Y
---
T
Q
Q
K
A
T
IKNG
K
D
VAQDG
S
S
S
LP
YT
PE
H
AFT
L
WSQY
QA
TD
D
I
S
V
G
AGA
R
Y
I
G
S--
-
---
-
M
H
KG
SDGAV
G
TPAFTE
G
-
Y
WVA
D
A
K
LG
Y
R
V
N
R
NL
D
FQLN
V
Y
NLFD
-
-
-
------
-
-
-
-
---
-
T
D
YVA
SI
N
KSG
Y
R
Y
H
PG
EP
RT
FL
L
TA
N
M
HF
fig|155864.1.peg.877
Escherichia coli O157:H7 EDL933 (10-760/760)
RQF
HSLT
FFAG
L
-
CI
G
IT
-
P
V
A
Q
A
LA
A
E
GQTNA
DDTLVV
E
A
-
S
T
P
SL
-
Y
AP
QQ
S
ADP
KFSRPVADTTRTM
TV
I
S
EQVI
KD
Q
GAT
NLT
D
AL
K
N
V
PGV
G
A
FFA
GE
N
GNST
T
G
D
-----
A
I
Y
M
RG
ADTS
N
S-
------
IYIDG
-
-
IR
D
I
G
SV
----
--S
RDT
FN
---------
T
E
Q
VEV
IK
GP
S
GT
D
YG
R
SA
P
T
G
S
IN
M
I
S
KQP
RN---
-
--
D
S
G
I
D
A
SA
S
IGSAWFR
R
GT
L
D
V
N
QV
I
-
GD
TTAV
RL
NV
MGE
--
KT
H
D
-
---
--
-
--
-
-----
---------
AGR
DK
V
K
N
E
-----
-
R
YGV
AP
--
S
IAFGL
G
TANRLY
L
N
Y
LHV
TQ
HNTP
D
GGIPTIGLPGYSAPS
AG
T
AT
LN
HS
G
K
V
D
T
HNF
Y
GT
--
-
---
D
SD
Y
D
D
S
T
T
D
T
ATMRF
EH
DINDNTTIRNT
TR
W
SR
VK
QD
YLMT
A
IM
G
-----
G
ASNITQPT
S
-------
D
V
N
S
W
T
W
S
RTA
NT
K
D
VSNKI
L
T
--
NQT
NLTS
TF
YT
A
S
IG
HDV
S
T
G
V
E
FTR
E
T
Q
TNYGV
N
PVT
L
PAV
N
I
YHP
DSS
I
HP
G
GL
T
R
NG
------------------
A
N
A
N
GQ
TD
TFA
I
YA
FD
T
LQ
I
T
R
D
F
E
L
N
GG
I
R
L
D
-
-
-----
NYH
TEYDSATAC
G
G
S
G
RGAI
T
CPA
G
V
A
KG
SPVTTVDTAKSGNLVN
W
KA
G
ALY
H
LT
E
N
GN
V
YI
N
YA
VSQQ
P
P
G
G
N
NF
A
LA
Q
S
G
SGNSANRT
DFK
PQ
K
ANT
S
EIGT
KWQ
VL
D
K
R
L
L
LT
A
A
L
FR
T
D
IE
N
EV
E
-
-
-
-
--
-
QN
DD
GT
----
Y
S
Q
Y
GK
K
R
VEG
Y
E
I
S
VAGNIT
P
----
--A
W
QV
I
G
G
Y
---
T
Q
Q
K
A
T
IKNG
K
D
VAQDG
S
S
S
LP
YT
PE
H
AFT
L
WSQY
QA
TD
D
I
S
V
G
AGA
R
Y
I
G
S--
-
---
-
M
H
KG
SDGAV
G
TPAFTE
G
-
Y
WVA
D
A
K
LG
Y
R
V
N
R
NL
D
FQLN
V
Y
NLFD
-
-
-
------
-
-
-
-
---
-
T
D
YVA
SI
N
KSG
Y
R
Y
H
PG
EP
RT
FL
L
TA
N
M
HF
fig|155864.8.peg.903
Escherichia coli O157:H7 EDL933 (10-760/760)
RQF
HSLT
FFAG
L
-
CI
G
IT
-
P
V
A
Q
A
LA
A
E
GQTNA
DDTLVV
E
A
-
S
T
P
SL
-
Y
AP
QQ
S
ADP
KFSRPVADTTRTM
TV
I
S
EQVI
KD
Q
GAT
NLT
D
AL
K
N
V
PGV
G
A
FFA
GE
N
GNST
T
G
D
-----
A
I
Y
M
RG
ADTS
N
S-
------
IYIDG
-
-
IR
D
I
G
SV
----
--S
RDT
FN
---------
T
E
Q
VEV
IK
GP
S
GT
D
YG
R
SA
P
T
G
S
IN
M
I
S
KQP
RN---
-
--
D
S
G
I
D
A
SA
S
IGSAWFR
R
GT
L
D
V
N
QV
I
-
GD
TTAV
RL
NV
MGE
--
KT
H
D
-
---
--
-
--
-
-----
---------
AGR
DK
V
K
N
E
-----
-
R
YGV
AP
--
S
IAFGL
G
TANRLY
L
N
Y
LHV
TQ
HNTP
D
GGIPTIGLPGYSAPS
AG
T
AT
LN
HS
G
K
V
D
T
HNF
Y
GT
--
-
---
D
SD
Y
D
D
S
T
T
D
T
ATMRF
EH
DINDNTTIRNT
TR
W
SR
VK
QD
YLMT
A
IM
G
-----
G
ASNITQPT
S
-------
D
V
N
S
W
T
W
S
RTA
NT
K
D
VSNKI
L
T
--
NQT
NLTS
TF
YT
A
S
IG
HDV
S
T
G
V
E
FTR
E
T
Q
TNYGV
N
PVT
L
PAV
N
I
YHP
DSS
I
HP
G
GL
T
R
NG
------------------
A
N
A
N
GQ
TD
TFA
I
YA
FD
T
LQ
I
T
R
D
F
E
L
N
GG
I
R
L
D
-
-
-----
NYH
TEYDSATAC
G
G
S
G
RGAI
T
CPA
G
V
A
KG
SPVTTVDTAKSGNLVN
W
KA
G
ALY
H
LT
E
N
GN
V
YI
N
YA
VSQQ
P
P
G
G
N
NF
A
LA
Q
S
G
SGNSANRT
DFK
PQ
K
ANT
S
EIGT
KWQ
VL
D
K
R
L
L
LT
A
A
L
FR
T
D
IE
N
EV
E
-
-
-
-
--
-
QN
DD
GT
----
Y
S
Q
Y
GK
K
R
VEG
Y
E
I
S
VAGNIT
P
----
--A
W
QV
I
G
G
Y
---
T
Q
Q
K
A
T
IKNG
K
D
VAQDG
S
S
S
LP
YT
PE
H
AFT
L
WSQY
QA
TD
D
I
S
V
G
AGA
R
Y
I
G
S--
-
---
-
M
H
KG
SDGAV
G
TPAFTE
G
-
Y
WVA
D
A
K
LG
Y
R
V
N
R
NL
D
FQLN
V
Y
NLFD
-
-
-
------
-
-
-
-
---
-
T
D
YVA
SI
N
KSG
Y
R
Y
H
PG
EP
RT
FL
L
TA
N
M
HF
fig|444454.5.peg.5374
Escherichia coli O157:H7 str. EC4024 (10-760/760)
RQF
HSLT
FFAG
L
-
CI
G
IT
-
P
V
A
Q
A
LA
A
E
GQTNA
DDTLVV
E
A
-
S
T
P
SL
-
Y
AP
QQ
S
ADP
KFSRPVADTTRTM
TV
I
S
EQVI
KD
Q
GAT
NLT
D
AL
K
N
V
PGV
G
A
FFA
GE
N
GNST
T
G
D
-----
A
I
Y
M
RG
ADTS
N
S-
------
IYIDG
-
-
IR
D
I
G
SV
----
--S
RDT
FN
---------
T
E
Q
VEV
IK
GP
S
GT
D
YG
R
SA
P
T
G
S
IN
M
I
S
KQP
RN---
-
--
D
S
G
I
D
A
SA
S
IGSAWFR
R
GT
L
D
V
N
QV
I
-
GD
TTAV
RL
NV
MGE
--
KT
H
D
-
---
--
-
--
-
-----
---------
AGR
DK
V
K
N
E
-----
-
R
YGV
AP
--
S
IAFGL
G
TANRLY
L
N
Y
LHV
TQ
HNTP
D
GGIPTIGLPGYSAPS
AG
T
AT
LN
HS
G
K
V
D
T
HNF
Y
GT
--
-
---
D
SD
Y
D
D
S
T
T
D
T
ATMRF
EH
DINDNTTIRNT
TR
W
SR
VK
QD
YLMT
A
IM
G
-----
G
ASNITQPT
S
-------
D
V
N
S
W
T
W
S
RTA
NT
K
D
VSNKI
L
T
--
NQT
NLTS
TF
YT
A
S
IG
HDV
S
T
G
V
E
FTR
E
T
Q
TNYGV
N
PVT
L
PAV
N
I
YHP
DSS
I
HP
G
GL
T
R
NG
------------------
A
N
A
N
GQ
TD
TFA
I
YA
FD
T
LQ
I
T
R
D
F
E
L
N
GG
I
R
L
D
-
-
-----
NYH
TEYDSATAC
G
G
S
G
RGAI
T
CPA
G
V
A
KG
SPVTTVDTAKSGNLVN
W
KA
G
ALY
H
LT
E
N
GN
V
YI
N
YA
VSQQ
P
P
G
G
N
NF
A
LA
Q
S
G
SGNSANRT
DFK
PQ
K
ANT
S
EIGT
KWQ
VL
D
K
R
L
L
LT
A
A
L
FR
T
D
IE
N
EV
E
-
-
-
-
--
-
QN
DD
GT
----
Y
S
Q
Y
GK
K
R
VEG
Y
E
I
S
VAGNIT
P
----
--A
W
QV
I
G
G
Y
---
T
Q
Q
K
A
T
IKNG
K
D
VAQDG
S
S
S
LP
YT
PE
H
AFT
L
WSQY
QA
TD
D
I
S
V
G
AGA
R
Y
I
G
S--
-
---
-
M
H
KG
SDGAV
G
TPAFTE
G
-
Y
WVA
D
A
K
LG
Y
R
V
N
R
NL
D
FQLN
V
Y
NLFD
-
-
-
------
-
-
-
-
---
-
T
D
YVA
SI
N
KSG
Y
R
Y
H
PG
EP
RT
FL
L
TA
N
M
HF
fig|444449.5.peg.4308
Escherichia coli O157:H7 str. EC4042 (10-760/760)
RQF
HSLT
FFAG
L
-
CI
G
IT
-
P
V
A
Q
A
LA
A
E
GQTNA
DDTLVV
E
A
-
S
T
P
SL
-
Y
AP
QQ
S
ADP
KFSRPVADTTRTM
TV
I
S
EQVI
KD
Q
GAT
NLT
D
AL
K
N
V
PGV
G
A
FFA
GE
N
GNST
T
G
D
-----
A
I
Y
M
RG
ADTS
N
S-
------
IYIDG
-
-
IR
D
I
G
SV
----
--S
RDT
FN
---------
T
E
Q
VEV
IK
GP
S
GT
D
YG
R
SA
P
T
G
S
IN
M
I
S
KQP
RN---
-
--
D
S
G
I
D
A
SA
S
IGSAWFR
R
GT
L
D
V
N
QV
I
-
GD
TTAV
RL
NV
MGE
--
KT
H
D
-
---
--
-
--
-
-----
---------
AGR
DK
V
K
N
E
-----
-
R
YGV
AP
--
S
IAFGL
G
TANRLY
L
N
Y
LHV
TQ
HNTP
D
GGIPTIGLPGYSAPS
AG
T
AT
LN
HS
G
K
V
D
T
HNF
Y
GT
--
-
---
D
SD
Y
D
D
S
T
T
D
T
ATMRF
EH
DINDNTTIRNT
TR
W
SR
VK
QD
YLMT
A
IM
G
-----
G
ASNITQPT
S
-------
D
V
N
S
W
T
W
S
RTA
NT
K
D
VSNKI
L
T
--
NQT
NLTS
TF
YT
A
S
IG
HDV
S
T
G
V
E
FTR
E
T
Q
TNYGV
N
PVT
L
PAV
N
I
YHP
DSS
I
HP
G
GL
T
R
NG
------------------
A
N
A
N
GQ
TD
TFA
I
YA
FD
T
LQ
I
T
R
D
F
E
L
N
GG
I
R
L
D
-
-
-----
NYH
TEYDSATAC
G
G
S
G
RGAI
T
CPA
G
V
A
KG
SPVTTVDTAKSGNLVN
W
KA
G
ALY
H
LT
E
N
GN
V
YI
N
YA
VSQQ
P
P
G
G
N
NF
A
LA
Q
S
G
SGNSANRT
DFK
PQ
K
ANT
S
EIGT
KWQ
VL
D
K
R
L
L
LT
A
A
L
FR
T
D
IE
N
EV
E
-
-
-
-
--
-
QN
DD
GT
----
Y
S
Q
Y
GK
K
R
VEG
Y
E
I
S
VAGNIT
P
----
--A
W
QV
I
G
G
Y
---
T
Q
Q
K
A
T
IKNG
K
D
VAQDG
S
S
S
LP
YT
PE
H
AFT
L
WSQY
QA
TD
D
I
S
V
G
AGA
R
Y
I
G
S--
-
---
-
M
H
KG
SDGAV
G
TPAFTE
G
-
Y
WVA
D
A
K
LG
Y
R
V
N
R
NL
D
FQLN
V
Y
NLFD
-
-
-
------
-
-
-
-
---
-
T
D
YVA
SI
N
KSG
Y
R
Y
H
PG
EP
RT
FL
L
TA
N
M
HF
fig|444448.5.peg.3584
Escherichia coli O157:H7 str. EC4045 (10-760/760)
RQF
HSLT
FFAG
L
-
CI
G
IT
-
P
V
A
Q
A
LA
A
E
GQTNA
DDTLVV
E
A
-
S
T
P
SL
-
Y
AP
QQ
S
ADP
KFSRPVADTTRTM
TV
I
S
EQVI
KD
Q
GAT
NLT
D
AL
K
N
V
PGV
G
A
FFA
GE
N
GNST
T
G
D
-----
A
I
Y
M
RG
ADTS
N
S-
------
IYIDG
-
-
IR
D
I
G
SV
----
--S
RDT
FN
---------
T
E
Q
VEV
IK
GP
S
GT
D
YG
R
SA
P
T
G
S
IN
M
I
S
KQP
RN---
-
--
D
S
G
I
D
A
SA
S
IGSAWFR
R
GT
L
D
V
N
QV
I
-
GD
TTAV
RL
NV
MGE
--
KT
H
D
-
---
--
-
--
-
-----
---------
AGR
DK
V
K
N
E
-----
-
R
YGV
AP
--
S
IAFGL
G
TANRLY
L
N
Y
LHV
TQ
HNTP
D
GGIPTIGLPGYSAPS
AG
T
AT
LN
HS
G
K
V
D
T
HNF
Y
GT
--
-
---
D
SD
Y
D
D
S
T
T
D
T
ATMRF
EH
DINDNTTIRNT
TR
W
SR
VK
QD
YLMT
A
IM
G
-----
G
ASNITQPT
S
-------
D
V
N
S
W
T
W
S
RTA
NT
K
D
VSNKI
L
T
--
NQT
NLTS
TF
YT
A
S
IG
HDV
S
T
G
V
E
FTR
E
T
Q
TNYGV
N
PVT
L
PAV
N
I
YHP
DSS
I
HP
G
GL
T
R
NG
------------------
A
N
A
N
GQ
TD
TFA
I
YA
FD
T
LQ
I
T
R
D
F
E
L
N
GG
I
R
L
D
-
-
-----
NYH
TEYDSATAC
G
G
S
G
RGAI
T
CPA
G
V
A
KG
SPVTTVDTAKSGNLVN
W
KA
G
ALY
H
LT
E
N
GN
V
YI
N
YA
VSQQ
P
P
G
G
N
NF
A
LA
Q
S
G
SGNSANRT
DFK
PQ
K
ANT
S
EIGT
KWQ
VL
D
K
R
L
L
LT
A
A
L
FR
T
D
IE
N
EV
E
-
-
-
-
--
-
QN
DD
GT
----
Y
S
Q
Y
GK
K
R
VEG
Y
E
I
S
VAGNIT
P
----
--A
W
QV
I
G
G
Y
---
T
Q
Q
K
A
T
IKNG
K
D
VAQDG
S
S
S
LP
YT
PE
H
AFT
L
WSQY
QA
TD
D
I
S
V
G
AGA
R
Y
I
G
S--
-
---
-
M
H
KG
SDGAV
G
TPAFTE
G
-
Y
WVA
D
A
K
LG
Y
R
V
N
R
NL
D
FQLN
V
Y
NLFD
-
-
-
------
-
-
-
-
---
-
T
D
YVA
SI
N
KSG
Y
R
Y
H
PG
EP
RT
FL
L
TA
N
M
HF
fig|444453.5.peg.926
Escherichia coli O157:H7 str. EC4076 (10-760/760)
RQF
HSLT
FFAG
L
-
CI
G
IT
-
P
V
A
Q
A
LA
A
E
GQTNA
DDTLVV
E
A
-
S
T
P
SL
-
Y
AP
QQ
S
ADP
KFSRPVADTTRTM
TV
I
S
EQVI
KD
Q
GAT
NLT
D
AL
K
N
V
PGV
G
A
FFA
GE
N
GNST
T
G
D
-----
A
I
Y
M
RG
ADTS
N
S-
------
IYIDG
-
-
IR
D
I
G
SV
----
--S
RDT
FN
---------
T
E
Q
VEV
IK
GP
S
GT
D
YG
R
SA
P
T
G
S
IN
M
I
S
KQP
RN---
-
--
D
S
G
I
D
A
SA
S
IGSAWFR
R
GT
L
D
V
N
QV
I
-
GD
TTAV
RL
NV
MGE
--
KT
H
D
-
---
--
-
--
-
-----
---------
AGR
DK
V
K
N
E
-----
-
R
YGV
AP
--
S
IAFGL
G
TANRLY
L
N
Y
LHV
TQ
HNTP
D
GGIPTIGLPGYSAPS
AG
T
AT
LN
HS
G
K
V
D
T
HNF
Y
GT
--
-
---
D
SD
Y
D
D
S
T
T
D
T
ATMRF
EH
DINDNTTIRNT
TR
W
SR
VK
QD
YLMT
A
IM
G
-----
G
ASNITQPT
S
-------
D
V
N
S
W
T
W
S
RTA
NT
K
D
VSNKI
L
T
--
NQT
NLTS
TF
YT
A
S
IG
HDV
S
T
G
V
E
FTR
E
T
Q
TNYGV
N
PVT
L
PAV
N
I
YHP
DSS
I
HP
G
GL
T
R
NG
------------------
A
N
A
N
GQ
TD
TFA
I
YA
FD
T
LQ
I
T
R
D
F
E
L
N
GG
I
R
L
D
-
-
-----
NYH
TEYDSATAC
G
G
S
G
RGAI
T
CPA
G
V
A
KG
SPVTTVDTAKSGNLVN
W
KA
G
ALY
H
LT
E
N
GN
V
YI
N
YA
VSQQ
P
P
G
G
N
NF
A
LA
Q
S
G
SGNSANRT
DFK
PQ
K
ANT
S
EIGT
KWQ
VL
D
K
R
L
L
LT
A
A
L
FR
T
D
IE
N
EV
E
-
-
-
-
--
-
QN
DD
GT
----
Y
S
Q
Y
GK
K
R
VEG
Y
E
I
S
VAGNIT
P
----
--A
W
QV
I
G
G
Y
---
T
Q
Q
K
A
T
IKNG
K
D
VAQDG
S
S
S
LP
YT
PE
H
AFT
L
WSQY
QA
TD
D
I
S
V
G
AGA
R
Y
I
G
S--
-
---
-
M
H
KG
SDGAV
G
TPAFTE
G
-
Y
WVA
D
A
K
LG
Y
R
V
N
R
NL
D
FQLN
V
Y
NLFD
-
-
-
------
-
-
-
-
---
-
T
D
YVA
SI
N
KSG
Y
R
Y
H
PG
EP
RT
FL
L
TA
N
M
HF
fig|444450.8.peg.1041
Escherichia coli O157:H7 str. EC4115 (10-760/760)
RQF
HSLT
FFAG
L
-
CI
G
IT
-
P
V
A
Q
A
LA
A
E
GQTNA
DDTLVV
E
A
-
S
T
P
SL
-
Y
AP
QQ
S
ADP
KFSRPVADTTRTM
TV
I
S
EQVI
KD
Q
GAT
NLT
D
AL
K
N
V
PGV
G
A
FFA
GE
N
GNST
T
G
D
-----
A
I
Y
M
RG
ADTS
N
S-
------
IYIDG
-
-
IR
D
I
G
SV
----
--S
RDT
FN
---------
T
E
Q
VEV
IK
GP
S
GT
D
YG
R
SA
P
T
G
S
IN
M
I
S
KQP
RN---
-
--
D
S
G
I
D
A
SA
S
IGSAWFR
R
GT
L
D
V
N
QV
I
-
GD
TTAV
RL
NV
MGE
--
KT
H
D
-
---
--
-
--
-
-----
---------
AGR
DK
V
K
N
E
-----
-
R
YGV
AP
--
S
IAFGL
G
TANRLY
L
N
Y
LHV
TQ
HNTP
D
GGIPTIGLPGYSAPS
AG
T
AT
LN
HS
G
K
V
D
T
HNF
Y
GT
--
-
---
D
SD
Y
D
D
S
T
T
D
T
ATMRF
EH
DINDNTTIRNT
TR
W
SR
VK
QD
YLMT
A
IM
G
-----
G
ASNITQPT
S
-------
D
V
N
S
W
T
W
S
RTA
NT
K
D
VSNKI
L
T
--
NQT
NLTS
TF
YT
A
S
IG
HDV
S
T
G
V
E
FTR
E
T
Q
TNYGV
N
PVT
L
PAV
N
I
YHP
DSS
I
HP
G
GL
T
R
NG
------------------
A
N
A
N
GQ
TD
TFA
I
YA
FD
T
LQ
I
T
R
D
F
E
L
N
GG
I
R
L
D
-
-
-----
NYH
TEYDSATAC
G
G
S
G
RGAI
T
CPA
G
V
A
KG
SPVTTVDTAKSGNLVN
W
KA
G
ALY
H
LT
E
N
GN
V
YI
N
YA
VSQQ
P
P
G
G
N
NF
A
LA
Q
S
G
SGNSANRT
DFK
PQ
K
ANT
S
EIGT
KWQ
VL
D
K
R
L
L
LT
A
A
L
FR
T
D
IE
N
EV
E
-
-
-
-
--
-
QN
DD
GT
----
Y
S
Q
Y
GK
K
R
VEG
Y
E
I
S
VAGNIT
P
----
--A
W
QV
I
G
G
Y
---
T
Q
Q
K
A
T
IKNG
K
D
VAQDG
S
S
S
LP
YT
PE
H
AFT
L
WSQY
QA
TD
D
I
S
V
G
AGA
R
Y
I
G
S--
-
---
-
M
H
KG
SDGAV
G
TPAFTE
G
-
Y
WVA
D
A
K
LG
Y
R
V
N
R
NL
D
FQLN
V
Y
NLFD
-
-
-
------
-
-
-
-
---
-
T
D
YVA
SI
N
KSG
Y
R
Y
H
PG
EP
RT
FL
L
TA
N
M
HF
fig|444451.5.peg.4681
Escherichia coli O157:H7 str. EC4196 (10-760/760)
RQF
HSLT
FFAG
L
-
CI
G
IT
-
P
V
A
Q
A
LA
A
E
GQTNA
DDTLVV
E
A
-
S
T
P
SL
-
Y
AP
QQ
S
ADP
KFSRPVADTTRTM
TV
I
S
EQVI
KD
Q
GAT
NLT
D
AL
K
N
V
PGV
G
A
FFA
GE
N
GNST
T
G
D
-----
A
I
Y
M
RG
ADTS
N
S-
------
IYIDG
-
-
IR
D
I
G
SV
----
--S
RDT
FN
---------
T
E
Q
VEV
IK
GP
S
GT
D
YG
R
SA
P
T
G
S
IN
M
I
S
KQP
RN---
-
--
D
S
G
I
D
A
SA
S
IGSAWFR
R
GT
L
D
V
N
QV
I
-
GD
TTAV
RL
NV
MGE
--
KT
H
D
-
---
--
-
--
-
-----
---------
AGR
DK
V
K
N
E
-----
-
R
YGV
AP
--
S
IAFGL
G
TANRLY
L
N
Y
LHV
TQ
HNTP
D
GGIPTIGLPGYSAPS
AG
T
AT
LN
HS
G
K
V
D
T
HNF
Y
GT
--
-
---
D
SD
Y
D
D
S
T
T
D
T
ATMRF
EH
DINDNTTIRNT
TR
W
SR
VK
QD
YLMT
A
IM
G
-----
G
ASNITQPT
S
-------
D
V
N
S
W
T
W
S
RTA
NT
K
D
VSNKI
L
T
--
NQT
NLTS
TF
YT
A
S
IG
HDV
S
T
G
V
E
FTR
E
T
Q
TNYGV
N
PVT
L
PAV
N
I
YHP
DSS
I
HP
G
GL
T
R
NG
------------------
A
N
A
N
GQ
TD
TFA
I
YA
FD
T
LQ
I
T
R
D
F
E
L
N
GG
I
R
L
D
-
-
-----
NYH
TEYDSATAC
G
G
S
G
RGAI
T
CPA
G
V
A
KG
SPVTTVDTAKSGNLVN
W
KA
G
ALY
H
LT
E
N
GN
V
YI
N
YA
VSQQ
P
P
G
G
N
NF
A
LA
Q
S
G
SGNSANRT
DFK
PQ
K
ANT
S
EIGT
KWQ
VL
D
K
R
L
L
LT
A
A
L
FR
T
D
IE
N
EV
E
-
-
-
-
--
-
QN
DD
GT
----
Y
S
Q
Y
GK
K
R
VEG
Y
E
I
S
VAGNIT
P
----
--A
W
QV
I
G
G
Y
---
T
Q
Q
K
A
T
IKNG
K
D
VAQDG
S
S
S
LP
YT
PE
H
AFT
L
WSQY
QA
TD
D
I
S
V
G
AGA
R
Y
I
G
S--
-
---
-
M
H
KG
SDGAV
G
TPAFTE
G
-
Y
WVA
D
A
K
LG
Y
R
V
N
R
NL
D
FQLN
V
Y
NLFD
-
-
-
------
-
-
-
-
---
-
T
D
YVA
SI
N
KSG
Y
R
Y
H
PG
EP
RT
FL
L
TA
N
M
HF
fig|478004.5.peg.3303
Escherichia coli O157:H7 str. EC4401 (10-760/760)
RQF
HSLT
FFAG
L
-
CI
G
IT
-
P
V
A
Q
A
LA
A
E
GQTNA
DDTLVV
E
A
-
S
T
P
SL
-
Y
AP
QQ
S
ADP
KFSRPVADTTRTM
TV
I
S
EQVI
KD
Q
GAT
NLT
D
AL
K
N
V
PGV
G
A
FFA
GE
N
GNST
T
G
D
-----
A
I
Y
M
RG
ADTS
N
S-
------
IYIDG
-
-
IR
D
I
G
SV
----
--S
RDT
FN
---------
T
E
Q
VEV
IK
GP
S
GT
D
YG
R
SA
P
T
G
S
IN
M
I
S
KQP
RN---
-
--
D
S
G
I
D
A
SA
S
IGSAWFR
R
GT
L
D
V
N
QV
I
-
GD
TTAV
RL
NV
MGE
--
KT
H
D
-
---
--
-
--
-
-----
---------
AGR
DK
V
K
N
E
-----
-
R
YGV
AP
--
S
IAFGL
G
TANRLY
L
N
Y
LHV
TQ
HNTP
D
GGIPTIGLPGYSAPS
AG
T
AT
LN
HS
G
K
V
D
T
HNF
Y
GT
--
-
---
D
SD
Y
D
D
S
T
T
D
T
ATMRF
EH
DINDNTTIRNT
TR
W
SR
VK
QD
YLMT
A
IM
G
-----
G
ASNITQPT
S
-------
D
V
N
S
W
T
W
S
RTA
NT
K
D
VSNKI
L
T
--
NQT
NLTS
TF
YT
A
S
IG
HDV
S
T
G
V
E
FTR
E
T
Q
TNYGV
N
PVT
L
PAV
N
I
YHP
DSS
I
HP
G
GL
T
R
NG
------------------
A
N
A
N
GQ
TD
TFA
I
YA
FD
T
LQ
I
T
R
D
F
E
L
N
GG
I
R
L
D
-
-
-----
NYH
TEYDSATAC
G
G
S
G
RGAI
T
CPA
G
V
A
KG
SPVTTVDTAKSGNLVN
W
KA
G
ALY
H
LT
E
N
GN
V
YI
N
YA
VSQQ
P
P
G
G
N
NF
A
LA
Q
S
G
SGNSANRT
DFK
PQ
K
ANT
S
EIGT
KWQ
VL
D
K
R
L
L
LT
A
A
L
FR
T
D
IE
N
EV
E
-
-
-
-
--
-
QN
DD
GT
----
Y
S
Q
Y
GK
K
R
VEG
Y
E
I
S
VAGNIT
P
----
--A
W
QV
I
G
G
Y
---
T
Q
Q
K
A
T
IKNG
K
D
VAQDG
S
S
S
LP
YT
PE
H
AFT
L
WSQY
QA
TD
D
I
S
V
G
AGA
R
Y
I
G
S--
-
---
-
M
H
KG
SDGAV
G
TPAFTE
G
-
Y
WVA
D
A
K
LG
Y
R
V
N
R
NL
D
FQLN
V
Y
NLFD
-
-
-
------
-
-
-
-
---
-
T
D
YVA
SI
N
KSG
Y
R
Y
H
PG
EP
RT
FL
L
TA
N
M
HF
fig|478006.5.peg.4607
Escherichia coli O157:H7 str. EC4501 (10-760/760)
RQF
HSLT
FFAG
L
-
CI
G
IT
-
P
V
A
Q
A
LA
A
E
GQTNA
DDTLVV
E
A
-
S
T
P
SL
-
Y
AP
QQ
S
ADP
KFSRPVADTTRTM
TV
I
S
EQVI
KD
Q
GAT
NLT
D
AL
K
N
V
PGV
G
A
FFA
GE
N
GNST
T
G
D
-----
A
I
Y
M
RG
ADTS
N
S-
------
IYIDG
-
-
IR
D
I
G
SV
----
--S
RDT
FN
---------
T
E
Q
VEV
IK
GP
S
GT
D
YG
R
SA
P
T
G
S
IN
M
I
S
KQP
RN---
-
--
D
S
G
I
D
A
SA
S
IGSAWFR
R
GT
L
D
V
N
QV
I
-
GD
TTAV
RL
NV
MGE
--
KT
H
D
-
---
--
-
--
-
-----
---------
AGR
DK
V
K
N
E
-----
-
R
YGV
AP
--
S
IAFGL
G
TANRLY
L
N
Y
LHV
TQ
HNTP
D
GGIPTIGLPGYSAPS
AG
T
AT
LN
HS
G
K
V
D
T
HNF
Y
GT
--
-
---
D
SD
Y
D
D
S
T
T
D
T
ATMRF
EH
DINDNTTIRNT
TR
W
SR
VK
QD
YLMT
A
IM
G
-----
G
ASNITQPT
S
-------
D
V
N
S
W
T
W
S
RTA
NT
K
D
VSNKI
L
T
--
NQT
NLTS
TF
YT
A
S
IG
HDV
S
T
G
V
E
FTR
E
T
Q
TNYGV
N
PVT
L
PAV
N
I
YHP
DSS
I
HP
G
GL
T
R
NG
------------------
A
N
A
N
GQ
TD
TFA
I
YA
FD
T
LQ
I
T
R
D
F
E
L
N
GG
I
R
L
D
-
-
-----
NYH
TEYDSATAC
G
G
S
G
RGAI
T
CPA
G
V
A
KG
SPVTTVDTAKSGNLVN
W
KA
G
ALY
H
LT
E
N
GN
V
YI
N
YA
VSQQ
P
P
G
G
N
NF
A
LA
Q
S
G
SGNSANRT
DFK
PQ
K
ANT
S
EIGT
KWQ
VL
D
K
R
L
L
LT
A
A
L
FR
T
D
IE
N
EV
E
-
-
-
-
--
-
QN
DD
GT
----
Y
S
Q
Y
GK
K
R
VEG
Y
E
I
S
VAGNIT
P
----
--A
W
QV
I
G
G
Y
---
T
Q
Q
K
A
T
IKNG
K
D
VAQDG
S
S
S
LP
YT
PE
H
AFT
L
WSQY
QA
TD
D
I
S
V
G
AGA
R
Y
I
G
S--
-
---
-
M
H
KG
SDGAV
G
TPAFTE
G
-
Y
WVA
D
A
K
LG
Y
R
V
N
R
NL
D
FQLN
V
Y
NLFD
-
-
-
------
-
-
-
-
---
-
T
D
YVA
SI
N
KSG
Y
R
Y
H
PG
EP
RT
FL
L
TA
N
M
HF
fig|478007.5.peg.2629
Escherichia coli O157:H7 str. EC508 (10-760/760)
RQF
HSLT
FFAG
L
-
CI
G
IT
-
P
V
A
Q
A
LA
A
E
GQTNA
DDTLVV
E
A
-
S
T
P
SL
-
Y
AP
QQ
S
ADP
KFSRPVADTTRTM
TV
I
S
EQVI
KD
Q
GAT
NLT
D
AL
K
N
V
PGV
G
A
FFA
GE
N
GNST
T
G
D
-----
A
I
Y
M
RG
ADTS
N
S-
------
IYIDG
-
-
IR
D
I
G
SV
----
--S
RDT
FN
---------
T
E
Q
VEV
IK
GP
S
GT
D
YG
R
SA
P
T
G
S
IN
M
I
S
KQP
RN---
-
--
D
S
G
I
D
A
SA
S
IGSAWFR
R
GT
L
D
V
N
QV
I
-
GD
TTAV
RL
NV
MGE
--
KT
H
D
-
---
--
-
--
-
-----
---------
AGR
DK
V
K
N
E
-----
-
R
YGV
AP
--
S
IAFGL
G
TANRLY
L
N
Y
LHV
TQ
HNTP
D
GGIPTIGLPGYSAPS
AG
T
AT
LN
HS
G
K
V
D
T
HNF
Y
GT
--
-
---
D
SD
Y
D
D
S
T
T
D
T
ATMRF
EH
DINDNTTIRNT
TR
W
SR
VK
QD
YLMT
A
IM
G
-----
G
ASNITQPT
S
-------
D
V
N
S
W
T
W
S
RTA
NT
K
D
VSNKI
L
T
--
NQT
NLTS
TF
YT
A
S
IG
HDV
S
T
G
V
E
FTR
E
T
Q
TNYGV
N
PVT
L
PAV
N
I
YHP
DSS
I
HP
G
GL
T
R
NG
------------------
A
N
A
N
GQ
TD
TFA
I
YA
FD
T
LQ
I
T
R
D
F
E
L
N
GG
I
R
L
D
-
-
-----
NYH
TEYDSATAC
G
G
S
G
RGAI
T
CPA
G
V
A
KG
SPVTTVDTAKSGNLVN
W
KA
G
ALY
H
LT
E
N
GN
V
YI
N
YA
VSQQ
P
P
G
G
N
NF
A
LA
Q
S
G
SGNSANRT
DFK
PQ
K
ANT
S
EIGT
KWQ
VL
D
K
R
L
L
LT
A
A
L
FR
T
D
IE
N
EV
E
-
-
-
-
--
-
QN
DD
GT
----
Y
S
Q
Y
GK
K
R
VEG
Y
E
I
S
VAGNIT
P
----
--A
W
QV
I
G
G
Y
---
T
Q
Q
K
A
T
IKNG
K
D
VAQDG
S
S
S
LP
YT
PE
H
AFT
L
WSQY
QA
TD
D
I
S
V
G
AGA
R
Y
I
G
S--
-
---
-
M
H
KG
SDGAV
G
TPAFTE
G
-
Y
WVA
D
A
K
LG
Y
R
V
N
R
NL
D
FQLN
V
Y
NLFD
-
-
-
------
-
-
-
-
---
-
T
D
YVA
SI
N
KSG
Y
R
Y
H
PG
EP
RT
FL
L
TA
N
M
HF
fig|478008.5.peg.2275
Escherichia coli O157:H7 str. EC869 (10-760/760)
RQF
HSLT
FFAG
L
-
CI
G
IT
-
P
V
A
Q
A
LA
A
E
GQTNA
DDTLVV
E
A
-
S
T
P
SL
-
Y
AP
QQ
S
ADP
KFSRPVADTTRTM
TV
I
S
EQVI
KD
Q
GAT
NLT
D
AL
K
N
V
PGV
G
A
FFA
GE
N
GNST
T
G
D
-----
A
I
Y
M
RG
ADTS
N
S-
------
IYIDG
-
-
IR
D
I
G
SV
----
--S
RDT
FN
---------
T
E
Q
VEV
IK
GP
S
GT
D
YG
R
SA
P
T
G
S
IN
M
I
S
KQP
RN---
-
--
D
S
G
I
D
A
SA
S
IGSAWFR
R
GT
L
D
V
N
QV
I
-
GD
TTAV
RL
NV
MGE
--
KT
H
D
-
---
--
-
--
-
-----
---------
AGR
DK
V
K
N
E
-----
-
R
YGV
AP
--
S
IAFGL
G
TANRLY
L
N
Y
LHV
TQ
HNTP
D
GGIPTIGLPGYSAPS
AG
T
AT
LN
HS
G
K
V
D
T
HNF
Y
GT
--
-
---
D
SD
Y
D
D
S
T
T
D
T
ATMRF
EH
DINDNTTIRNT
TR
W
SR
VK
QD
YLMT
A
IM
G
-----
G
ASNITQPT
S
-------
D
V
N
S
W
T
W
S
RTA
NT
K
D
VSNKI
L
T
--
NQT
NLTS
TF
YT
A
S
IG
HDV
S
T
G
V
E
FTR
E
T
Q
TNYGV
N
PVT
L
PAV
N
I
YHP
DSS
I
HP
G
GL
T
R
NG
------------------
A
N
A
N
GQ
TD
TFA
I
YA
FD
T
LQ
I
T
R
D
F
E
L
N
GG
I
R
L
D
-
-
-----
NYH
TEYDSATAC
G
G
S
G
RGAI
T
CPA
G
V
A
KG
SPVTTVDTAKSGNLVN
W
KA
G
ALY
H
LT
E
N
GN
V
YI
N
YA
VSQQ
P
P
G
G
N
NF
A
LA
Q
S
G
SGNSANRT
DFK
PQ
K
ANT
S
EIGT
KWQ
VL
D
K
R
L
L
LT
A
A
L
FR
T
D
IE
N
EV
E
-
-
-
-
--
-
QN
DD
GT
----
Y
S
Q
Y
GK
K
R
VEG
Y
E
I
S
VAGNIT
P
----
--A
W
QV
I
G
G
Y
---
T
Q
Q
K
A
T
IKNG
K
D
VAQDG
S
S
S
LP
YT
PE
H
AFT
L
WSQY
QA
TD
D
I
S
V
G
AGA
R
Y
I
G
S--
-
---
-
M
H
KG
SDGAV
G
TPAFTE
G
-
Y
WVA
D
A
K
LG
Y
R
V
N
R
NL
D
FQLN
V
Y
NLFD
-
-
-
------
-
-
-
-
---
-
T
D
YVA
SI
N
KSG
Y
R
Y
H
PG
EP
RT
FL
L
TA
N
M
HF
fig|637388.3.peg.2575
Escherichia coli O157:H7 str. FRIK2000 (10-760/760)
RQF
HSLT
FFAG
L
-
CI
G
IT
-
P
V
A
Q
A
LA
A
E
GQTNA
DDTLVV
E
A
-
S
T
P
SL
-
Y
AP
QQ
S
ADP
KFSRPVADTTRTM
TV
I
S
EQVI
KD
Q
GAT
NLT
D
AL
K
N
V
PGV
G
A
FFA
GE
N
GNST
T
G
D
-----
A
I
Y
M
RG
ADTS
N
S-
------
IYIDG
-
-
IR
D
I
G
SV
----
--S
RDT
FN
---------
T
E
Q
VEV
IK
GP
S
GT
D
YG
R
SA
P
T
G
S
IN
M
I
S
KQP
RN---
-
--
D
S
G
I
D
A
SA
S
IGSAWFR
R
GT
L
D
V
N
QV
I
-
GD
TTAV
RL
NV
MGE
--
KT
H
D
-
---
--
-
--
-
-----
---------
AGR
DK
V
K
N
E
-----
-
R
YGV
AP
--
S
IAFGL
G
TANRLY
L
N
Y
LHV
TQ
HNTP
D
GGIPTIGLPGYSAPS
AG
T
AT
LN
HS
G
K
V
D
T
HNF
Y
GT
--
-
---
D
SD
Y
D
D
S
T
T
D
T
ATMRF
EH
DINDNTTIRNT
TR
W
SR
VK
QD
YLMT
A
IM
G
-----
G
ASNITQPT
S
-------
D
V
N
S
W
T
W
S
RTA
NT
K
D
VSNKI
L
T
--
NQT
NLTS
TF
YT
A
S
IG
HDV
S
T
G
V
E
FTR
E
T
Q
TNYGV
N
PVT
L
PAV
N
I
YHP
DSS
I
HP
G
GL
T
R
NG
------------------
A
N
A
N
GQ
TD
TFA
I
YA
FD
T
LQ
I
T
R
D
F
E
L
N
GG
I
R
L
D
-
-
-----
NYH
TEYDSATAC
G
G
S
G
RGAI
T
CPA
G
V
A
KG
SPVTTVDTAKSGNLVN
W
KA
G
ALY
H
LT
E
N
GN
V
YI
N
YA
VSQQ
P
P
G
G
N
NF
A
LA
Q
S
G
SGNSANRT
DFK
PQ
K
ANT
S
EIGT
KWQ
VL
D
K
R
L
L
LT
A
A
L
FR
T
D
IE
N
EV
E
-
-
-
-
--
-
QN
DD
GT
----
Y
S
Q
Y
GK
K
R
VEG
Y
E
I
S
VAGNIT
P
----
--A
W
QV
I
G
G
Y
---
T
Q
Q
K
A
T
IKNG
K
D
VAQDG
S
S
S
LP
YT
PE
H
AFT
L
WSQY
QA
TD
D
I
S
V
G
AGA
R
Y
I
G
S--
-
---
-
M
H
KG
SDGAV
G
TPAFTE
G
-
Y
WVA
D
A
K
LG
Y
R
V
N
R
NL
D
FQLN
V
Y
NLFD
-
-
-
------
-
-
-
-
---
-
T
D
YVA
SI
N
KSG
Y
R
Y
H
PG
EP
RT
FL
L
TA
N
M
HF
fig|570506.3.peg.4454
Escherichia coli O157:H7 str. FRIK966 (10-760/760)
RQF
HSLT
FFAG
L
-
CI
G
IT
-
P
V
A
Q
A
LA
A
E
GQTNA
DDTLVV
E
A
-
S
T
P
SL
-
Y
AP
QQ
S
ADP
KFSRPVADTTRTM
TV
I
S
EQVI
KD
Q
GAT
NLT
D
AL
K
N
V
PGV
G
A
FFA
GE
N
GNST
T
G
D
-----
A
I
Y
M
RG
ADTS
N
S-
------
IYIDG
-
-
IR
D
I
G
SV
----
--S
RDT
FN
---------
T
E
Q
VEV
IK
GP
S
GT
D
YG
R
SA
P
T
G
S
IN
M
I
S
KQP
RN---
-
--
D
S
G
I
D
A
SA
S
IGSAWFR
R
GT
L
D
V
N
QV
I
-
GD
TTAV
RL
NV
MGE
--
KT
H
D
-
---
--
-
--
-
-----
---------
AGR
DK
V
K
N
E
-----
-
R
YGV
AP
--
S
IAFGL
G
TANRLY
L
N
Y
LHV
TQ
HNTP
D
GGIPTIGLPGYSAPS
AG
T
AT
LN
HS
G
K
V
D
T
HNF
Y
GT
--
-
---
D
SD
Y
D
D
S
T
T
D
T
ATMRF
EH
DINDNTTIRNT
TR
W
SR
VK
QD
YLMT
A
IM
G
-----
G
ASNITQPT
S
-------
D
V
N
S
W
T
W
S
RTA
NT
K
D
VSNKI
L
T
--
NQT
NLTS
TF
YT
A
S
IG
HDV
S
T
G
V
E
FTR
E
T
Q
TNYGV
N
PVT
L
PAV
N
I
YHP
DSS
I
HP
G
GL
T
R
NG
------------------
A
N
A
N
GQ
TD
TFA
I
YA
FD
T
LQ
I
T
R
D
F
E
L
N
GG
I
R
L
D
-
-
-----
NYH
TEYDSATAC
G
G
S
G
RGAI
T
CPA
G
V
A
KG
SPVTTVDTAKSGNLVN
W
KA
G
ALY
H
LT
E
N
GN
V
YI
N
YA
VSQQ
P
P
G
G
N
NF
A
LA
Q
S
G
SGNSANRT
DFK
PQ
K
ANT
S
EIGT
KWQ
VL
D
K
R
L
L
LT
A
A
L
FR
T
D
IE
N
EV
E
-
-
-
-
--
-
QN
DD
GT
----
Y
S
Q
Y
GK
K
R
VEG
Y
E
I
S
VAGNIT
P
----
--A
W
QV
I
G
G
Y
---
T
Q
Q
K
A
T
IKNG
K
D
VAQDG
S
S
S
LP
YT
PE
H
AFT
L
WSQY
QA
TD
D
I
S
V
G
AGA
R
Y
I
G
S--
-
---
-
M
H
KG
SDGAV
G
TPAFTE
G
-
Y
WVA
D
A
K
LG
Y
R
V
N
R
NL
D
FQLN
V
Y
NLFD
-
-
-
------
-
-
-
-
---
-
T
D
YVA
SI
N
KSG
Y
R
Y
H
PG
EP
RT
FL
L
TA
N
M
HF
fig|386585.9.peg.997
Escherichia coli O157:H7 str. Sakai (10-760/760)
RQF
HSLT
FFAG
L
-
CI
G
IT
-
P
V
A
Q
A
LA
A
E
GQTNA
DDTLVV
E
A
-
S
T
P
SL
-
Y
AP
QQ
S
ADP
KFSRPVADTTRTM
TV
I
S
EQVI
KD
Q
GAT
NLT
D
AL
K
N
V
PGV
G
A
FFA
GE
N
GNST
T
G
D
-----
A
I
Y
M
RG
ADTS
N
S-
------
IYIDG
-
-
IR
D
I
G
SV
----
--S
RDT
FN
---------
T
E
Q
VEV
IK
GP
S
GT
D
YG
R
SA
P
T
G
S
IN
M
I
S
KQP
RN---
-
--
D
S
G
I
D
A
SA
S
IGSAWFR
R
GT
L
D
V
N
QV
I
-
GD
TTAV
RL
NV
MGE
--
KT
H
D
-
---
--
-
--
-
-----
---------
AGR
DK
V
K
N
E
-----
-
R
YGV
AP
--
S
IAFGL
G
TANRLY
L
N
Y
LHV
TQ
HNTP
D
GGIPTIGLPGYSAPS
AG
T
AT
LN
HS
G
K
V
D
T
HNF
Y
GT
--
-
---
D
SD
Y
D
D
S
T
T
D
T
ATMRF
EH
DINDNTTIRNT
TR
W
SR
VK
QD
YLMT
A
IM
G
-----
G
ASNITQPT
S
-------
D
V
N
S
W
T
W
S
RTA
NT
K
D
VSNKI
L
T
--
NQT
NLTS
TF
YT
A
S
IG
HDV
S
T
G
V
E
FTR
E
T
Q
TNYGV
N
PVT
L
PAV
N
I
YHP
DSS
I
HP
G
GL
T
R
NG
------------------
A
N
A
N
GQ
TD
TFA
I
YA
FD
T
LQ
I
T
R
D
F
E
L
N
GG
I
R
L
D
-
-
-----
NYH
TEYDSATAC
G
G
S
G
RGAI
T
CPA
G
V
A
KG
SPVTTVDTAKSGNLVN
W
KA
G
ALY
H
LT
E
N
GN
V
YI
N
YA
VSQQ
P
P
G
G
N
NF
A
LA
Q
S
G
SGNSANRT
DFK
PQ
K
ANT
S
EIGT
KWQ
VL
D
K
R
L
L
LT
A
A
L
FR
T
D
IE
N
EV
E
-
-
-
-
--
-
QN
DD
GT
----
Y
S
Q
Y
GK
K
R
VEG
Y
E
I
S
VAGNIT
P
----
--A
W
QV
I
G
G
Y
---
T
Q
Q
K
A
T
IKNG
K
D
VAQDG
S
S
S
LP
YT
PE
H
AFT
L
WSQY
QA
TD
D
I
S
V
G
AGA
R
Y
I
G
S--
-
---
-
M
H
KG
SDGAV
G
TPAFTE
G
-
Y
WVA
D
A
K
LG
Y
R
V
N
R
NL
D
FQLN
V
Y
NLFD
-
-
-
------
-
-
-
-
---
-
T
D
YVA
SI
N
KSG
Y
R
Y
H
PG
EP
RT
FL
L
TA
N
M
HF
fig|544404.4.peg.907
Escherichia coli O157:H7 str. TW14359 (10-760/760)
RQF
HSLT
FFAG
L
-
CI
G
IT
-
P
V
A
Q
A
LA
A
E
GQTNA
DDTLVV
E
A
-
S
T
P
SL
-
Y
AP
QQ
S
ADP
KFSRPVADTTRTM
TV
I
S
EQVI
KD
Q
GAT
NLT
D
AL
K
N
V
PGV
G
A
FFA
GE
N
GNST
T
G
D
-----
A
I
Y
M
RG
ADTS
N
S-
------
IYIDG
-
-
IR
D
I
G
SV
----
--S
RDT
FN
---------
T
E
Q
VEV
IK
GP
S
GT
D
YG
R
SA
P
T
G
S
IN
M
I
S
KQP
RN---
-
--
D
S
G
I
D
A
SA
S
IGSAWFR
R
GT
L
D
V
N
QV
I
-
GD
TTAV
RL
NV
MGE
--
KT
H
D
-
---
--
-
--
-
-----
---------
AGR
DK
V
K
N
E
-----
-
R
YGV
AP
--
S
IAFGL
G
TANRLY
L
N
Y
LHV
TQ
HNTP
D
GGIPTIGLPGYSAPS
AG
T
AT
LN
HS
G
K
V
D
T
HNF
Y
GT
--
-
---
D
SD
Y
D
D
S
T
T
D
T
ATMRF
EH
DINDNTTIRNT
TR
W
SR
VK
QD
YLMT
A
IM
G
-----
G
ASNITQPT
S
-------
D
V
N
S
W
T
W
S
RTA
NT
K
D
VSNKI
L
T
--
NQT
NLTS
TF
YT
A
S
IG
HDV
S
T
G
V
E
FTR
E
T
Q
TNYGV
N
PVT
L
PAV
N
I
YHP
DSS
I
HP
G
GL
T
R
NG
------------------
A
N
A
N
GQ
TD
TFA
I
YA
FD
T
LQ
I
T
R
D
F
E
L
N
GG
I
R
L
D
-
-
-----
NYH
TEYDSATAC
G
G
S
G
RGAI
T
CPA
G
V
A
KG
SPVTTVDTAKSGNLVN
W
KA
G
ALY
H
LT
E
N
GN
V
YI
N
YA
VSQQ
P
P
G
G
N
NF
A
LA
Q
S
G
SGNSANRT
DFK
PQ
K
ANT
S
EIGT
KWQ
VL
D
K
R
L
L
LT
A
A
L
FR
T
D
IE
N
EV
E
-
-
-
-
--
-
QN
DD
GT
----
Y
S
Q
Y
GK
K
R
VEG
Y
E
I
S
VAGNIT
P
----
--A
W
QV
I
G
G
Y
---
T
Q
Q
K
A
T
IKNG
K
D
VAQDG
S
S
S
LP
YT
PE
H
AFT
L
WSQY
QA
TD
D
I
S
V
G
AGA
R
Y
I
G
S--
-
---
-
M
H
KG
SDGAV
G
TPAFTE
G
-
Y
WVA
D
A
K
LG
Y
R
V
N
R
NL
D
FQLN
V
Y
NLFD
-
-
-
------
-
-
-
-
---
-
T
D
YVA
SI
N
KSG
Y
R
Y
H
PG
EP
RT
FL
L
TA
N
M
HF
fig|502346.5.peg.308
Escherichia coli O157:H7 str. TW14588 (10-760/760)
RQF
HSLT
FFAG
L
-
CI
G
IT
-
P
V
A
Q
A
LA
A
E
GQTNA
DDTLVV
E
A
-
S
T
P
SL
-
Y
AP
QQ
S
ADP
KFSRPVADTTRTM
TV
I
S
EQVI
KD
Q
GAT
NLT
D
AL
K
N
V
PGV
G
A
FFA
GE
N
GNST
T
G
D
-----
A
I
Y
M
RG
ADTS
N
S-
------
IYIDG
-
-
IR
D
I
G
SV
----
--S
RDT
FN
---------
T
E
Q
VEV
IK
GP
S
GT
D
YG
R
SA
P
T
G
S
IN
M
I
S
KQP
RN---
-
--
D
S
G
I
D
A
SA
S
IGSAWFR
R
GT
L
D
V
N
QV
I
-
GD
TTAV
RL
NV
MGE
--
KT
H
D
-
---
--
-
--
-
-----
---------
AGR
DK
V
K
N
E
-----
-
R
YGV
AP
--
S
IAFGL
G
TANRLY
L
N
Y
LHV
TQ
HNTP
D
GGIPTIGLPGYSAPS
AG
T
AT
LN
HS
G
K
V
D
T
HNF
Y
GT
--
-
---
D
SD
Y
D
D
S
T
T
D
T
ATMRF
EH
DINDNTTIRNT
TR
W
SR
VK
QD
YLMT
A
IM
G
-----
G
ASNITQPT
S
-------
D
V
N
S
W
T
W
S
RTA
NT
K
D
VSNKI
L
T
--
NQT
NLTS
TF
YT
A
S
IG
HDV
S
T
G
V
E
FTR
E
T
Q
TNYGV
N
PVT
L
PAV
N
I
YHP
DSS
I
HP
G
GL
T
R
NG
------------------
A
N
A
N
GQ
TD
TFA
I
YA
FD
T
LQ
I
T
R
D
F
E
L
N
GG
I
R
L
D
-
-
-----
NYH
TEYDSATAC
G
G
S
G
RGAI
T
CPA
G
V
A
KG
SPVTTVDTAKSGNLVN
W
KA
G
ALY
H
LT
E
N
GN
V
YI
N
YA
VSQQ
P
P
G
G
N
NF
A
LA
Q
S
G
SGNSANRT
DFK
PQ
K
ANT
S
EIGT
KWQ
VL
D
K
R
L
L
LT
A
A
L
FR
T
D
IE
N
EV
E
-
-
-
-
--
-
QN
DD
GT
----
Y
S
Q
Y
GK
K
R
VEG
Y
E
I
S
VAGNIT
P
----
--A
W
QV
I
G
G
Y
---
T
Q
Q
K
A
T
IKNG
K
D
VAQDG
S
S
S
LP
YT
PE
H
AFT
L
WSQY
QA
TD
D
I
S
V
G
AGA
R
Y
I
G
S--
-
---
-
M
H
KG
SDGAV
G
TPAFTE
G
-
Y
WVA
D
A
K
LG
Y
R
V
N
R
NL
D
FQLN
V
Y
NLFD
-
-
-
------
-
-
-
-
---
-
T
D
YVA
SI
N
KSG
Y
R
Y
H
PG
EP
RT
FL
L
TA
N
M
HF
fig|701177.3.peg.1015
Escherichia coli O55:H7 str. CB9615 (10-760/760)
RQF
HSLT
FFAG
L
-
CI
G
IT
-
P
V
A
Q
A
LA
A
E
GQTNA
DDTLVV
E
A
-
S
T
P
SL
-
Y
AP
QQ
S
ADP
KFSRPVADTTRTM
TV
I
S
EQVI
KD
Q
GAT
NLT
D
AL
K
N
V
PGV
G
A
FFA
GE
N
GNST
T
G
D
-----
A
I
Y
M
RG
ADTS
N
S-
------
IYIDG
-
-
IR
D
I
G
SV
----
--S
RDT
FN
---------
T
E
Q
VEV
IK
GP
S
GT
D
YG
R
SA
P
T
G
S
IN
M
I
S
KQP
RN---
-
--
D
S
G
I
D
A
SA
S
IGSAWFR
R
GT
L
D
V
N
QV
I
-
GD
TTAV
RL
NV
MGE
--
KT
H
D
-
---
--
-
--
-
-----
---------
AGR
DK
V
K
N
E
-----
-
R
YGV
AP
--
S
IAFGL
G
TANRLY
L
N
Y
LHV
TQ
HNTP
D
GGIPTIGLPGYSAPS
AG
T
AT
LN
HS
G
K
V
D
T
HNF
Y
GT
--
-
---
D
SD
Y
D
D
S
T
T
D
T
ATMRF
EH
DINDNTTIRNT
TR
W
SR
VK
QD
YLMT
A
IM
G
-----
G
ASNITQPT
S
-------
D
V
N
S
W
T
W
S
RTA
NT
K
D
VSNKI
L
T
--
NQT
NLTS
TF
YT
A
S
IG
HDV
S
T
G
V
E
FTR
E
T
Q
TNYGV
N
PVT
L
PAV
N
I
YHP
DSS
I
HP
G
GL
T
R
NG
------------------
A
N
A
N
GQ
TD
TFA
I
YA
FD
T
LQ
I
T
R
D
F
E
L
N
GG
I
R
L
D
-
-
-----
NYH
TEYDSATAC
G
G
S
G
RGAI
T
CPA
G
V
A
KG
SPVTTVDTAKSGNLVN
W
KA
G
ALY
H
LT
E
N
GN
V
YI
N
YA
VSQQ
P
P
G
G
N
NF
A
LA
Q
S
G
SGNSANRT
DFK
PQ
K
ANT
S
EIGT
KWQ
VL
D
K
R
L
L
LT
A
A
L
FR
T
D
IE
N
EV
E
-
-
-
-
--
-
QN
DD
GT
----
Y
S
Q
Y
GK
K
R
VEG
Y
E
I
S
VAGNIT
P
----
--A
W
QV
I
G
G
Y
---
T
Q
Q
K
A
T
IKNG
K
D
VAQDG
S
S
S
LP
YT
PE
H
AFT
L
WSQY
QA
TD
D
I
S
V
G
AGA
R
Y
I
G
S--
-
---
-
M
H
KG
SDGAV
G
TPAFTE
G
-
Y
WVA
D
A
K
LG
Y
R
V
N
R
NL
D
FQLN
V
Y
NLFD
-
-
-
------
-
-
-
-
---
-
T
D
YVA
SI
N
KSG
Y
R
Y
H
PG
EP
RT
FL
L
TA
N
M
HF
fig|656444.3.peg.1356
Escherichia coli TA280 (10-760/760)
RQF
HSLT
FFAG
L
-
CI
G
IT
-
P
V
A
Q
A
LA
A
E
GQANA
DDTLVV
E
A
-
S
T
P
SL
-
Y
AP
QQ
S
ADP
KFSRPVADTTRTM
TV
I
S
EQVI
KD
Q
GAT
NLT
D
AL
K
N
V
PGV
G
A
FFA
GE
N
GNST
T
G
D
-----
A
I
Y
M
RG
ADTS
N
S-
------
IYIDG
-
-
IR
D
I
G
SV
----
--S
RDT
FN
---------
T
E
Q
VEV
IK
GP
S
GT
D
YG
R
SA
P
T
G
S
IN
M
I
S
KQP
RN---
-
--
D
S
G
I
D
A
SA
S
IGSAWFR
R
GT
L
D
V
N
Q
A
I
-
GD
TTAV
RL
NV
MGE
--
KT
H
D
-
---
--
-
--
-
-----
---------
AGR
DK
I
K
N
E
-----
-
R
YGV
AP
--
S
VAFGL
G
TANRLY
L
N
Y
LHV
TQ
HNTP
D
GGIPTIGLPGYSAPS
AG
T
VA
LN
HS
G
K
V
D
T
HNF
Y
GT
--
-
---
D
SD
Y
D
D
S
T
T
D
T
ATMRF
EH
DINDNTTIRNT
TR
W
SR
VK
QD
YLMT
A
IM
G
-----
G
ASNITQPT
S
-------
D
V
N
S
W
T
W
S
RTA
NT
K
D
VSNKI
L
T
--
NQT
NLTS
TF
YT
GS
IG
HDV
S
T
G
V
E
FTR
E
T
Q
TNYGV
N
PVT
L
PAV
N
I
YHP
DSS
I
HP
G
GL
T
R
NG
------------------
A
N
A
N
GQ
TD
TFA
I
YA
FD
T
LQ
I
T
R
D
F
E
L
N
GG
I
R
L
D
-
-
-----
NYH
TEYDSATAC
G
G
S
G
RGAI
T
CPA
G
V
A
KG
SPVTTVDTAKSGNLVN
W
KA
G
ALY
H
LT
E
N
GN
V
YI
N
YA
VSQQ
P
P
G
G
N
NF
A
LA
Q
S
G
SGNSANRT
DFK
PQ
K
ANT
S
EIGT
KWQ
VL
D
K
R
L
L
LT
A
A
L
FR
T
D
IE
N
EV
E
-
-
-
-
--
-
QN
DD
GT
----
Y
S
Q
Y
GK
K
R
VEG
Y
E
I
S
VAGNIT
P
----
--A
W
QV
I
G
G
Y
---
T
Q
Q
K
A
T
IKNG
K
D
VAQDG
S
S
S
LP
YT
PE
H
AFT
L
WSQY
QA
TD
D
I
S
V
G
AGA
R
Y
I
G
S--
-
---
-
M
H
KG
SDGAV
G
TPAFTE
G
-
Y
WVA
D
A
K
LG
Y
R
V
N
R
NL
D
FQLN
V
Y
NLFD
-
-
-
------
-
-
-
-
---
-
T
D
YVA
SI
N
KSG
Y
R
Y
H
PG
EP
RT
FL
L
TA
N
M
HF
fig|670888.3.peg.1366
Escherichia coli 1827-70 (10-760/760)
RQF
HSLT
FFAG
L
-
CI
G
IT
-
P
V
A
Q
A
LA
A
E
GQTNA
DDTLVV
E
A
-
S
T
P
SL
-
Y
AP
QQ
S
ADP
KFSRPVADTTRTM
TV
I
S
EQVI
KD
Q
GAT
NLT
D
AL
K
N
V
PGV
G
A
FFA
GE
N
GNST
T
G
D
-----
A
I
Y
M
RG
ADTS
N
S-
------
IYIDG
-
-
IR
D
I
G
SV
----
--S
RDT
FN
---------
T
E
Q
VEV
IK
GP
S
GT
D
YG
R
SA
P
T
G
S
IN
M
I
S
KQP
RN---
-
--
D
S
G
I
D
A
SA
S
IGSAWFR
R
GT
L
D
V
N
QV
I
-
GD
TTAV
RL
NV
MGE
--
KT
H
D
-
---
--
-
--
-
-----
---------
AGR
DK
V
K
N
E
-----
-
R
YGV
AP
--
S
VAFGL
G
TANRLY
L
N
Y
LHV
TQ
HNTP
D
GGIPTIGLPGYSAPS
AG
T
AA
LN
HS
G
K
V
D
T
HNF
Y
GT
--
-
---
D
SD
Y
D
D
S
T
T
D
T
ATMRF
EH
DINDNTTIRNT
TR
W
SR
VK
QD
YLMT
A
IM
G
-----
G
ASNITQPT
S
-------
D
V
N
S
W
T
W
S
RTA
NT
K
D
VSNKI
L
T
--
NQT
NLTS
TF
YT
GS
IG
HDV
S
T
G
V
E
FTR
E
T
Q
TNYGV
N
PVT
L
PAV
N
I
YHP
DSS
I
HP
G
GL
T
R
NG
------------------
A
N
A
N
GQ
TD
TFA
I
YA
FD
T
LQ
I
T
R
D
F
E
L
N
GG
I
R
L
D
-
-
-----
NYH
TEYDSATAC
G
G
S
G
RGAI
T
CPT
G
V
A
KG
SPVTTVDTAKSGNL
M
N
W
KA
G
ALY
H
LT
E
N
GN
V
YI
N
YA
VSQQ
P
P
G
G
N
NF
A
LA
Q
S
G
SGNSANRT
DFK
PQ
K
ANT
S
EIGT
KWQ
VL
D
K
R
L
L
LT
A
A
L
FR
T
D
IE
N
EV
E
-
-
-
-
--
-
QN
DD
GT
----
Y
S
Q
Y
GK
K
R
VEG
Y
E
I
S
VAGNIT
P
----
--A
W
QV
I
G
G
Y
---
T
Q
Q
K
A
T
IKNG
K
D
VAQDG
S
S
S
LP
YT
PE
H
AFT
L
WSQY
QA
TD
D
I
S
V
G
AGA
R
Y
I
G
S--
-
---
-
M
H
KG
SDGAV
G
TPAFTE
G
-
Y
WVA
D
A
K
LG
Y
R
V
N
R
NL
D
FQLN
V
Y
NLFD
-
-
-
------
-
-
-
-
---
-
T
D
YVA
SI
N
KSG
Y
R
Y
H
PG
EP
RT
FL
L
TA
N
M
HF
fig|481805.3.peg.3050
Escherichia coli ATCC 8739 (10-760/760)
RQF
HSLT
FFAG
L
-
CI
G
IT
-
P
V
A
Q
A
LA
A
E
GQTNA
DDTLVV
E
A
-
S
T
P
SL
-
Y
AP
QQ
S
ADP
KFSRPVADTTRTM
TV
I
S
EQVI
KD
Q
GAT
NLT
D
AL
K
N
V
PGV
G
A
FFA
GE
N
GNST
T
G
D
-----
A
I
Y
M
RG
ADTS
N
S-
------
IYIDG
-
-
IR
D
I
G
SV
----
--S
RDT
FN
---------
T
E
Q
VEV
IK
GP
S
GT
D
YG
R
SA
P
T
G
S
IN
M
I
S
KQP
RN---
-
--
D
S
G
I
D
A
SA
S
IGSAWFR
R
GT
L
D
V
N
QV
I
-
GD
TTAV
RL
NV
MGE
--
KT
H
D
-
---
--
-
--
-
-----
---------
AGR
DK
V
K
N
E
-----
-
R
YGV
AP
--
S
VAFGL
G
TANRLY
L
N
Y
LHV
TQ
HNTP
D
GGIPTIGLPGYSAPS
AG
T
AA
LN
HS
G
K
V
D
T
HNF
Y
GT
--
-
---
D
SD
Y
D
D
S
T
T
D
T
ATMRF
EH
DINDNTTIRNT
TR
W
SR
VK
QD
YLMT
A
IM
G
-----
G
ASNITQPT
S
-------
D
V
N
S
W
T
W
S
RTA
NT
K
D
VSNKI
L
T
--
NQT
NLTS
TF
YT
GS
IG
HDV
S
T
G
V
E
FTR
E
T
Q
TNYGV
N
PVT
L
PAV
N
I
YHP
DSS
I
HP
G
GL
T
R
NG
------------------
A
N
A
N
GQ
TD
TFA
I
YA
FD
T
LQ
I
T
R
D
F
E
L
N
GG
I
R
L
D
-
-
-----
NYH
TEYDSATAC
G
G
S
G
RGAI
T
CPT
G
V
A
KG
SPVTTVDTAKSGNL
M
N
W
KA
G
ALY
H
LT
E
N
GN
V
YI
N
YA
VSQQ
P
P
G
G
N
NF
A
LA
Q
S
G
SGNSANRT
DFK
PQ
K
ANT
S
EIGT
KWQ
VL
D
K
R
L
L
LT
A
A
L
FR
T
D
IE
N
EV
E
-
-
-
-
--
-
QN
DD
GT
----
Y
S
Q
Y
GK
K
R
VEG
Y
E
I
S
VAGNIT
P
----
--A
W
QV
I
G
G
Y
---
T
Q
Q
K
A
T
IKNG
K
D
VAQDG
S
S
S
LP
YT
PE
H
AFT
L
WSQY
QA
TD
D
I
S
V
G
AGA
R
Y
I
G
S--
-
---
-
M
H
KG
SDGAV
G
TPAFTE
G
-
Y
WVA
D
A
K
LG
Y
R
V
N
R
NL
D
FQLN
V
Y
NLFD
-
-
-
------
-
-
-
-
---
-
T
D
YVA
SI
N
KSG
Y
R
Y
H
PG
EP
RT
FL
L
TA
N
M
HF
fig|481805.6.peg.3036
Escherichia coli ATCC 8739 (10-760/760)
RQF
HSLT
FFAG
L
-
CI
G
IT
-
P
V
A
Q
A
LA
A
E
GQTNA
DDTLVV
E
A
-
S
T
P
SL
-
Y
AP
QQ
S
ADP
KFSRPVADTTRTM
TV
I
S
EQVI
KD
Q
GAT
NLT
D
AL
K
N
V
PGV
G
A
FFA
GE
N
GNST
T
G
D
-----
A
I
Y
M
RG
ADTS
N
S-
------
IYIDG
-
-
IR
D
I
G
SV
----
--S
RDT
FN
---------
T
E
Q
VEV
IK
GP
S
GT
D
YG
R
SA
P
T
G
S
IN
M
I
S
KQP
RN---
-
--
D
S
G
I
D
A
SA
S
IGSAWFR
R
GT
L
D
V
N
QV
I
-
GD
TTAV
RL
NV
MGE
--
KT
H
D
-
---
--
-
--
-
-----
---------
AGR
DK
V
K
N
E
-----
-
R
YGV
AP
--
S
VAFGL
G
TANRLY
L
N
Y
LHV
TQ
HNTP
D
GGIPTIGLPGYSAPS
AG
T
AA
LN
HS
G
K
V
D
T
HNF
Y
GT
--
-
---
D
SD
Y
D
D
S
T
T
D
T
ATMRF
EH
DINDNTTIRNT
TR
W
SR
VK
QD
YLMT
A
IM
G
-----
G
ASNITQPT
S
-------
D
V
N
S
W
T
W
S
RTA
NT
K
D
VSNKI
L
T
--
NQT
NLTS
TF
YT
GS
IG
HDV
S
T
G
V
E
FTR
E
T
Q
TNYGV
N
PVT
L
PAV
N
I
YHP
DSS
I
HP
G
GL
T
R
NG
------------------
A
N
A
N
GQ
TD
TFA
I
YA
FD
T
LQ
I
T
R
D
F
E
L
N
GG
I
R
L
D
-
-
-----
NYH
TEYDSATAC
G
G
S
G
RGAI
T
CPT
G
V
A
KG
SPVTTVDTAKSGNL
M
N
W
KA
G
ALY
H
LT
E
N
GN
V
YI
N
YA
VSQQ
P
P
G
G
N
NF
A
LA
Q
S
G
SGNSANRT
DFK
PQ
K
ANT
S
EIGT
KWQ
VL
D
K
R
L
L
LT
A
A
L
FR
T
D
IE
N
EV
E
-
-
-
-
--
-
QN
DD
GT
----
Y
S
Q
Y
GK
K
R
VEG
Y
E
I
S
VAGNIT
P
----
--A
W
QV
I
G
G
Y
---
T
Q
Q
K
A
T
IKNG
K
D
VAQDG
S
S
S
LP
YT
PE
H
AFT
L
WSQY
QA
TD
D
I
S
V
G
AGA
R
Y
I
G
S--
-
---
-
M
H
KG
SDGAV
G
TPAFTE
G
-
Y
WVA
D
A
K
LG
Y
R
V
N
R
NL
D
FQLN
V
Y
NLFD
-
-
-
------
-
-
-
-
---
-
T
D
YVA
SI
N
KSG
Y
R
Y
H
PG
EP
RT
FL
L
TA
N
M
HF
fig|595496.3.peg.728
Escherichia coli BW2952 (10-760/760)
RQF
HSLT
FFAG
L
-
CI
G
IT
-
P
V
A
Q
A
LA
A
E
GQTNA
DDTLVV
E
A
-
S
T
P
SL
-
Y
AP
QQ
S
ADP
KFSRPVADTTRTM
TV
I
S
EQVI
KD
Q
GAT
NLT
D
AL
K
N
V
PGV
G
A
FFA
GE
N
GNST
T
G
D
-----
A
I
Y
M
RG
ADTS
N
S-
------
IYIDG
-
-
IR
D
I
G
SV
----
--S
RDT
FN
---------
T
E
Q
VEV
IK
GP
S
GT
D
YG
R
SA
P
T
G
S
IN
M
I
S
KQP
RN---
-
--
D
S
G
I
D
A
SA
S
IGSAWFR
R
GT
L
D
V
N
QV
I
-
GD
TTAV
RL
NV
MGE
--
KT
H
D
-
---
--
-
--
-
-----
---------
AGR
DK
V
K
N
E
-----
-
R
YGV
AP
--
S
VAFGL
G
TANRLY
L
N
Y
LHV
TQ
HNTP
D
GGIPTIGLPGYSAPS
AG
T
AA
LN
HS
G
K
V
D
T
HNF
Y
GT
--
-
---
D
SD
Y
D
D
S
T
T
D
T
ATMRF
EH
DINDNTTIRNT
TR
W
SR
VK
QD
YLMT
A
IM
G
-----
G
ASNITQPT
S
-------
D
V
N
S
W
T
W
S
RTA
NT
K
D
VSNKI
L
T
--
NQT
NLTS
TF
YT
GS
IG
HDV
S
T
G
V
E
FTR
E
T
Q
TNYGV
N
PVT
L
PAV
N
I
YHP
DSS
I
HP
G
GL
T
R
NG
------------------
A
N
A
N
GQ
TD
TFA
I
YA
FD
T
LQ
I
T
R
D
F
E
L
N
GG
I
R
L
D
-
-
-----
NYH
TEYDSATAC
G
G
S
G
RGAI
T
CPT
G
V
A
KG
SPVTTVDTAKSGNL
M
N
W
KA
G
ALY
H
LT
E
N
GN
V
YI
N
YA
VSQQ
P
P
G
G
N
NF
A
LA
Q
S
G
SGNSANRT
DFK
PQ
K
ANT
S
EIGT
KWQ
VL
D
K
R
L
L
LT
A
A
L
FR
T
D
IE
N
EV
E
-
-
-
-
--
-
QN
DD
GT
----
Y
S
Q
Y
GK
K
R
VEG
Y
E
I
S
VAGNIT
P
----
--A
W
QV
I
G
G
Y
---
T
Q
Q
K
A
T
IKNG
K
D
VAQDG
S
S
S
LP
YT
PE
H
AFT
L
WSQY
QA
TD
D
I
S
V
G
AGA
R
Y
I
G
S--
-
---
-
M
H
KG
SDGAV
G
TPAFTE
G
-
Y
WVA
D
A
K
LG
Y
R
V
N
R
NL
D
FQLN
V
Y
NLFD
-
-
-
------
-
-
-
-
---
-
T
D
YVA
SI
N
KSG
Y
R
Y
H
PG
EP
RT
FL
L
TA
N
M
HF
fig|536056.3.peg.2994
Escherichia coli DH1 (10-760/760)
RQF
HSLT
FFAG
L
-
CI
G
IT
-
P
V
A
Q
A
LA
A
E
GQTNA
DDTLVV
E
A
-
S
T
P
SL
-
Y
AP
QQ
S
ADP
KFSRPVADTTRTM
TV
I
S
EQVI
KD
Q
GAT
NLT
D
AL
K
N
V
PGV
G
A
FFA
GE
N
GNST
T
G
D
-----
A
I
Y
M
RG
ADTS
N
S-
------
IYIDG
-
-
IR
D
I
G
SV
----
--S
RDT
FN
---------
T
E
Q
VEV
IK
GP
S
GT
D
YG
R
SA
P
T
G
S
IN
M
I
S
KQP
RN---
-
--
D
S
G
I
D
A
SA
S
IGSAWFR
R
GT
L
D
V
N
QV
I
-
GD
TTAV
RL
NV
MGE
--
KT
H
D
-
---
--
-
--
-
-----
---------
AGR
DK
V
K
N
E
-----
-
R
YGV
AP
--
S
VAFGL
G
TANRLY
L
N
Y
LHV
TQ
HNTP
D
GGIPTIGLPGYSAPS
AG
T
AA
LN
HS
G
K
V
D
T
HNF
Y
GT
--
-
---
D
SD
Y
D
D
S
T
T
D
T
ATMRF
EH
DINDNTTIRNT
TR
W
SR
VK
QD
YLMT
A
IM
G
-----
G
ASNITQPT
S
-------
D
V
N
S
W
T
W
S
RTA
NT
K
D
VSNKI
L
T
--
NQT
NLTS
TF
YT
GS
IG
HDV
S
T
G
V
E
FTR
E
T
Q
TNYGV
N
PVT
L
PAV
N
I
YHP
DSS
I
HP
G
GL
T
R
NG
------------------
A
N
A
N
GQ
TD
TFA
I
YA
FD
T
LQ
I
T
R
D
F
E
L
N
GG
I
R
L
D
-
-
-----
NYH
TEYDSATAC
G
G
S
G
RGAI
T
CPT
G
V
A
KG
SPVTTVDTAKSGNL
M
N
W
KA
G
ALY
H
LT
E
N
GN
V
YI
N
YA
VSQQ
P
P
G
G
N
NF
A
LA
Q
S
G
SGNSANRT
DFK
PQ
K
ANT
S
EIGT
KWQ
VL
D
K
R
L
L
LT
A
A
L
FR
T
D
IE
N
EV
E
-
-
-
-
--
-
QN
DD
GT
----
Y
S
Q
Y
GK
K
R
VEG
Y
E
I
S
VAGNIT
P
----
--A
W
QV
I
G
G
Y
---
T
Q
Q
K
A
T
IKNG
K
D
VAQDG
S
S
S
LP
YT
PE
H
AFT
L
WSQY
QA
TD
D
I
S
V
G
AGA
R
Y
I
G
S--
-
---
-
M
H
KG
SDGAV
G
TPAFTE
G
-
Y
WVA
D
A
K
LG
Y
R
V
N
R
NL
D
FQLN
V
Y
NLFD
-
-
-
------
-
-
-
-
---
-
T
D
YVA
SI
N
KSG
Y
R
Y
H
PG
EP
RT
FL
L
TA
N
M
HF
fig|562.375.peg.4396
Escherichia coli EC4100B (10-760/760)
RQF
HSLT
FFAG
L
-
CI
G
IT
-
P
V
A
Q
A
LA
A
E
GQTNA
DDTLVV
E
A
-
S
T
P
SL
-
Y
AP
QQ
S
ADP
KFSRPVADTTRTM
TV
I
S
EQVI
KD
Q
GAT
NLT
D
AL
K
N
V
PGV
G
A
FFA
GE
N
GNST
T
G
D
-----
A
I
Y
M
RG
ADTS
N
S-
------
IYIDG
-
-
IR
D
I
G
SV
----
--S
RDT
FN
---------
T
E
Q
VEV
IK
GP
S
GT
D
YG
R
SA
P
T
G
S
IN
M
I
S
KQP
RN---
-
--
D
S
G
I
D
A
SA
S
IGSAWFR
R
GT
L
D
V
N
QV
I
-
GD
TTAV
RL
NV
MGE
--
KT
H
D
-
---
--
-
--
-
-----
---------
AGR
DK
V
K
N
E
-----
-
R
YGV
AP
--
S
VAFGL
G
TANRLY
L
N
Y
LHV
TQ
HNTP
D
GGIPTIGLPGYSAPS
AG
T
AA
LN
HS
G
K
V
D
T
HNF
Y
GT
--
-
---
D
SD
Y
D
D
S
T
T
D
T
ATMRF
EH
DINDNTTIRNT
TR
W
SR
VK
QD
YLMT
A
IM
G
-----
G
ASNITQPT
S
-------
D
V
N
S
W
T
W
S
RTA
NT
K
D
VSNKI
L
T
--
NQT
NLTS
TF
YT
GS
IG
HDV
S
T
G
V
E
FTR
E
T
Q
TNYGV
N
PVT
L
PAV
N
I
YHP
DSS
I
HP
G
GL
T
R
NG
------------------
A
N
A
N
GQ
TD
TFA
I
YA
FD
T
LQ
I
T
R
D
F
E
L
N
GG
I
R
L
D
-
-
-----
NYH
TEYDSATAC
G
G
S
G
RGAI
T
CPT
G
V
A
KG
SPVTTVDTAKSGNL
M
N
W
KA
G
ALY
H
LT
E
N
GN
V
YI
N
YA
VSQQ
P
P
G
G
N
NF
A
LA
Q
S
G
SGNSANRT
DFK
PQ
K
ANT
S
EIGT
KWQ
VL
D
K
R
L
L
LT
A
A
L
FR
T
D
IE
N
EV
E
-
-
-
-
--
-
QN
DD
GT
----
Y
S
Q
Y
GK
K
R
VEG
Y
E
I
S
VAGNIT
P
----
--A
W
QV
I
G
G
Y
---
T
Q
Q
K
A
T
IKNG
K
D
VAQDG
S
S
S
LP
YT
PE
H
AFT
L
WSQY
QA
TD
D
I
S
V
G
AGA
R
Y
I
G
S--
-
---
-
M
H
KG
SDGAV
G
TPAFTE
G
-
Y
WVA
D
A
K
LG
Y
R
V
N
R
NL
D
FQLN
V
Y
NLFD
-
-
-
------
-
-
-
-
---
-
T
D
YVA
SI
N
KSG
Y
R
Y
H
PG
EP
RT
FL
L
TA
N
M
HF
fig|316401.4.peg.1011
Escherichia coli ETEC H10407 (10-760/760)
RQF
HSLT
FFAG
L
-
CI
G
IT
-
P
V
A
Q
A
LA
A
E
GQTNA
DDTLVV
E
A
-
S
T
P
SL
-
Y
AP
QQ
S
ADP
KFSRPVADTTRTM
TV
I
S
EQVI
KD
Q
GAT
NLT
D
AL
K
N
V
PGV
G
A
FFA
GE
N
GNST
T
G
D
-----
A
I
Y
M
RG
ADTS
N
S-
------
IYIDG
-
-
IR
D
I
G
SV
----
--S
RDT
FN
---------
T
E
Q
VEV
IK
GP
S
GT
D
YG
R
SA
P
T
G
S
IN
M
I
S
KQP
RN---
-
--
D
S
G
I
D
A
SA
S
IGSAWFR
R
GT
L
D
V
N
QV
I
-
GD
TTAV
RL
NV
MGE
--
KT
H
D
-
---
--
-
--
-
-----
---------
AGR
DK
V
K
N
E
-----
-
R
YGV
AP
--
S
VAFGL
G
TANRLY
L
N
Y
LHV
TQ
HNTP
D
GGIPTIGLPGYSAPS
AG
T
AA
LN
HS
G
K
V
D
T
HNF
Y
GT
--
-
---
D
SD
Y
D
D
S
T
T
D
T
ATMRF
EH
DINDNTTIRNT
TR
W
SR
VK
QD
YLMT
A
IM
G
-----
G
ASNITQPT
S
-------
D
V
N
S
W
T
W
S
RTA
NT
K
D
VSNKI
L
T
--
NQT
NLTS
TF
YT
GS
IG
HDV
S
T
G
V
E
FTR
E
T
Q
TNYGV
N
PVT
L
PAV
N
I
YHP
DSS
I
HP
G
GL
T
R
NG
------------------
A
N
A
N
GQ
TD
TFA
I
YA
FD
T
LQ
I
T
R
D
F
E
L
N
GG
I
R
L
D
-
-
-----
NYH
TEYDSATAC
G
G
S
G
RGAI
T
CPT
G
V
A
KG
SPVTTVDTAKSGNL
M
N
W
KA
G
ALY
H
LT
E
N
GN
V
YI
N
YA
VSQQ
P
P
G
G
N
NF
A
LA
Q
S
G
SGNSANRT
DFK
PQ
K
ANT
S
EIGT
KWQ
VL
D
K
R
L
L
LT
A
A
L
FR
T
D
IE
N
EV
E
-
-
-
-
--
-
QN
DD
GT
----
Y
S
Q
Y
GK
K
R
VEG
Y
E
I
S
VAGNIT
P
----
--A
W
QV
I
G
G
Y
---
T
Q
Q
K
A
T
IKNG
K
D
VAQDG
S
S
S
LP
YT
PE
H
AFT
L
WSQY
QA
TD
D
I
S
V
G
AGA
R
Y
I
G
S--
-
---
-
M
H
KG
SDGAV
G
TPAFTE
G
-
Y
WVA
D
A
K
LG
Y
R
V
N
R
NL
D
FQLN
V
Y
NLFD
-
-
-
------
-
-
-
-
---
-
T
D
YVA
SI
N
KSG
Y
R
Y
H
PG
EP
RT
FL
L
TA
N
M
HF
fig|656414.3.peg.1004
Escherichia coli H736 (10-760/760)
RQF
HSLT
FFAG
L
-
CI
G
IT
-
P
V
A
Q
A
LA
A
E
GQTNA
DDTLVV
E
A
-
S
T
P
SL
-
Y
AP
QQ
S
ADP
KFSRPVADTTRTM
TV
I
S
EQVI
KD
Q
GAT
NLT
D
AL
K
N
V
PGV
G
A
FFA
GE
N
GNST
T
G
D
-----
A
I
Y
M
RG
ADTS
N
S-
------
IYIDG
-
-
IR
D
I
G
SV
----
--S
RDT
FN
---------
T
E
Q
VEV
IK
GP
S
GT
D
YG
R
SA
P
T
G
S
IN
M
I
S
KQP
RN---
-
--
D
S
G
I
D
A
SA
S
IGSAWFR
R
GT
L
D
V
N
QV
I
-
GD
TTAV
RL
NV
MGE
--
KT
H
D
-
---
--
-
--
-
-----
---------
AGR
DK
V
K
N
E
-----
-
R
YGV
AP
--
S
VAFGL
G
TANRLY
L
N
Y
LHV
TQ
HNTP
D
GGIPTIGLPGYSAPS
AG
T
AA
LN
HS
G
K
V
D
T
HNF
Y
GT
--
-
---
D
SD
Y
D
D
S
T
T
D
T
ATMRF
EH
DINDNTTIRNT
TR
W
SR
VK
QD
YLMT
A
IM
G
-----
G
ASNITQPT
S
-------
D
V
N
S
W
T
W
S
RTA
NT
K
D
VSNKI
L
T
--
NQT
NLTS
TF
YT
GS
IG
HDV
S
T
G
V
E
FTR
E
T
Q
TNYGV
N
PVT
L
PAV
N
I
YHP
DSS
I
HP
G
GL
T
R
NG
------------------
A
N
A
N
GQ
TD
TFA
I
YA
FD
T
LQ
I
T
R
D
F
E
L
N
GG
I
R
L
D
-
-
-----
NYH
TEYDSATAC
G
G
S
G
RGAI
T
CPT
G
V
A
KG
SPVTTVDTAKSGNL
M
N
W
KA
G
ALY
H
LT
E
N
GN
V
YI
N
YA
VSQQ
P
P
G
G
N
NF
A
LA
Q
S
G
SGNSANRT
DFK
PQ
K
ANT
S
EIGT
KWQ
VL
D
K
R
L
L
LT
A
A
L
FR
T
D
IE
N
EV
E
-
-
-
-
--
-
QN
DD
GT
----
Y
S
Q
Y
GK
K
R
VEG
Y
E
I
S
VAGNIT
P
----
--A
W
QV
I
G
G
Y
---
T
Q
Q
K
A
T
IKNG
K
D
VAQDG
S
S
S
LP
YT
PE
H
AFT
L
WSQY
QA
TD
D
I
S
V
G
AGA
R
Y
I
G
S--
-
---
-
M
H
KG
SDGAV
G
TPAFTE
G
-
Y
WVA
D
A
K
LG
Y
R
V
N
R
NL
D
FQLN
V
Y
NLFD
-
-
-
------
-
-
-
-
---
-
T
D
YVA
SI
N
KSG
Y
R
Y
H
PG
EP
RT
FL
L
TA
N
M
HF
fig|331112.3.peg.796
Escherichia coli HS (10-760/760)
RQF
HSLT
FFAG
L
-
CI
G
IT
-
P
V
A
Q
A
LA
A
E
GQTNA
DDTLVV
E
A
-
S
T
P
SL
-
Y
AP
QQ
S
ADP
KFSRPVADTTRTM
TV
I
S
EQVI
KD
Q
GAT
NLT
D
AL
K
N
V
PGV
G
A
FFA
GE
N
GNST
T
G
D
-----
A
I
Y
M
RG
ADTS
N
S-
------
IYIDG
-
-
IR
D
I
G
SV
----
--S
RDT
FN
---------
T
E
Q
VEV
IK
GP
S
GT
D
YG
R
SA
P
T
G
S
IN
M
I
S
KQP
RN---
-
--
D
S
G
I
D
A
SA
S
IGSAWFR
R
GT
L
D
V
N
QV
I
-
GD
TTAV
RL
NV
MGE
--
KT
H
D
-
---
--
-
--
-
-----
---------
AGR
DK
V
K
N
E
-----
-
R
YGV
AP
--
S
VAFGL
G
TANRLY
L
N
Y
LHV
TQ
HNTP
D
GGIPTIGLPGYSAPS
AG
T
AA
LN
HS
G
K
V
D
T
HNF
Y
GT
--
-
---
D
SD
Y
D
D
S
T
T
D
T
ATMRF
EH
DINDNTTIRNT
TR
W
SR
VK
QD
YLMT
A
IM
G
-----
G
ASNITQPT
S
-------
D
V
N
S
W
T
W
S
RTA
NT
K
D
VSNKI
L
T
--
NQT
NLTS
TF
YT
GS
IG
HDV
S
T
G
V
E
FTR
E
T
Q
TNYGV
N
PVT
L
PAV
N
I
YHP
DSS
I
HP
G
GL
T
R
NG
------------------
A
N
A
N
GQ
TD
TFA
I
YA
FD
T
LQ
I
T
R
D
F
E
L
N
GG
I
R
L
D
-
-
-----
NYH
TEYDSATAC
G
G
S
G
RGAI
T
CPT
G
V
A
KG
SPVTTVDTAKSGNL
M
N
W
KA
G
ALY
H
LT
E
N
GN
V
YI
N
YA
VSQQ
P
P
G
G
N
NF
A
LA
Q
S
G
SGNSANRT
DFK
PQ
K
ANT
S
EIGT
KWQ
VL
D
K
R
L
L
LT
A
A
L
FR
T
D
IE
N
EV
E
-
-
-
-
--
-
QN
DD
GT
----
Y
S
Q
Y
GK
K
R
VEG
Y
E
I
S
VAGNIT
P
----
--A
W
QV
I
G
G
Y
---
T
Q
Q
K
A
T
IKNG
K
D
VAQDG
S
S
S
LP
YT
PE
H
AFT
L
WSQY
QA
TD
D
I
S
V
G
AGA
R
Y
I
G
S--
-
---
-
M
H
KG
SDGAV
G
TPAFTE
G
-
Y
WVA
D
A
K
LG
Y
R
V
N
R
NL
D
FQLN
V
Y
NLFD
-
-
-
------
-
-
-
-
---
-
T
D
YVA
SI
N
KSG
Y
R
Y
H
PG
EP
RT
FL
L
TA
N
M
HF
fig|331112.6.peg.830
Escherichia coli HS (10-760/760)
RQF
HSLT
FFAG
L
-
CI
G
IT
-
P
V
A
Q
A
LA
A
E
GQTNA
DDTLVV
E
A
-
S
T
P
SL
-
Y
AP
QQ
S
ADP
KFSRPVADTTRTM
TV
I
S
EQVI
KD
Q
GAT
NLT
D
AL
K
N
V
PGV
G
A
FFA
GE
N
GNST
T
G
D
-----
A
I
Y
M
RG
ADTS
N
S-
------
IYIDG
-
-
IR
D
I
G
SV
----
--S
RDT
FN
---------
T
E
Q
VEV
IK
GP
S
GT
D
YG
R
SA
P
T
G
S
IN
M
I
S
KQP
RN---
-
--
D
S
G
I
D
A
SA
S
IGSAWFR
R
GT
L
D
V
N
QV
I
-
GD
TTAV
RL
NV
MGE
--
KT
H
D
-
---
--
-
--
-
-----
---------
AGR
DK
V
K
N
E
-----
-
R
YGV
AP
--
S
VAFGL
G
TANRLY
L
N
Y
LHV
TQ
HNTP
D
GGIPTIGLPGYSAPS
AG
T
AA
LN
HS
G
K
V
D
T
HNF
Y
GT
--
-
---
D
SD
Y
D
D
S
T
T
D
T
ATMRF
EH
DINDNTTIRNT
TR
W
SR
VK
QD
YLMT
A
IM
G
-----
G
ASNITQPT
S
-------
D
V
N
S
W
T
W
S
RTA
NT
K
D
VSNKI
L
T
--
NQT
NLTS
TF
YT
GS
IG
HDV
S
T
G
V
E
FTR
E
T
Q
TNYGV
N
PVT
L
PAV
N
I
YHP
DSS
I
HP
G
GL
T
R
NG
------------------
A
N
A
N
GQ
TD
TFA
I
YA
FD
T
LQ
I
T
R
D
F
E
L
N
GG
I
R
L
D
-
-
-----
NYH
TEYDSATAC
G
G
S
G
RGAI
T
CPT
G
V
A
KG
SPVTTVDTAKSGNL
M
N
W
KA
G
ALY
H
LT
E
N
GN
V
YI
N
YA
VSQQ
P
P
G
G
N
NF
A
LA
Q
S
G
SGNSANRT
DFK
PQ
K
ANT
S
EIGT
KWQ
VL
D
K
R
L
L
LT
A
A
L
FR
T
D
IE
N
EV
E
-
-
-
-
--
-
QN
DD
GT
----
Y
S
Q
Y
GK
K
R
VEG
Y
E
I
S
VAGNIT
P
----
--A
W
QV
I
G
G
Y
---
T
Q
Q
K
A
T
IKNG
K
D
VAQDG
S
S
S
LP
YT
PE
H
AFT
L
WSQY
QA
TD
D
I
S
V
G
AGA
R
Y
I
G
S--
-
---
-
M
H
KG
SDGAV
G
TPAFTE
G
-
Y
WVA
D
A
K
LG
Y
R
V
N
R
NL
D
FQLN
V
Y
NLFD
-
-
-
------
-
-
-
-
---
-
T
D
YVA
SI
N
KSG
Y
R
Y
H
PG
EP
RT
FL
L
TA
N
M
HF
fig|585057.6.peg.825
Escherichia coli IAI39 (10-760/760)
RQF
HSLT
FFAG
L
-
CI
G
IT
-
P
V
A
Q
A
LA
A
E
GQTNA
DDTLVV
E
A
-
S
T
P
SL
-
Y
AP
QQ
S
ADP
KFSRPVADTTRTM
TV
I
S
EQVI
KD
Q
GAT
NLT
D
AL
K
N
V
PGV
G
A
FFA
GE
N
GNST
T
G
D
-----
A
I
Y
M
RG
ADTS
N
S-
------
IYIDG
-
-
IR
D
I
G
SV
----
--S
RDT
FN
---------
T
E
Q
VEV
IK
GP
S
GT
D
YG
R
SA
P
T
G
S
IN
M
I
S
KQP
RN---
-
--
D
S
G
I
D
A
SA
S
IGSAWFR
R
GT
L
D
V
N
QV
I
-
GD
TTAV
RL
NV
MGE
--
KT
H
D
-
---
--
-
--
-
-----
---------
AGR
DK
V
K
N
E
-----
-
R
YGV
AP
--
S
VAFGL
G
TANRLY
L
N
Y
LHV
TQ
HNTP
D
GGIPTIGLPGYSAPS
AG
T
AA
LN
HS
G
K
V
D
T
HNF
Y
GT
--
-
---
D
SD
Y
D
D
S
T
T
D
T
ATMRF
EH
DINDNTTIRNT
TR
W
SR
VK
QD
YLMT
A
IM
G
-----
G
ASNITQPT
S
-------
D
V
N
S
W
T
W
S
RTA
NT
K
D
VSNKI
L
T
--
NQT
NLTS
TF
YT
GS
IG
HDV
S
T
G
V
E
FTR
E
T
Q
TNYGV
N
PVT
L
PAV
N
I
YHP
DSS
I
HP
G
GL
T
R
NG
------------------
A
N
A
N
GQ
TD
TFA
I
YA
FD
T
LQ
I
T
R
D
F
E
L
N
GG
I
R
L
D
-
-
-----
NYH
TEYDSATAC
G
G
S
G
RGAI
T
CPA
G
V
A
KG
SPVTTVDTAKSGNLVN
W
KA
G
ALY
H
LT
E
N
GN
I
YI
N
YA
VSQQ
P
P
G
G
N
NF
A
LA
Q
S
G
SGNSANRT
DFK
PQ
K
ANT
S
EIGT
KWQ
VL
D
K
R
L
L
LT
A
A
L
FR
T
D
IE
N
EV
E
-
-
-
-
--
-
QN
DD
GT
----
Y
S
Q
Y
GK
K
R
VEG
Y
E
I
S
VAGNIT
P
----
--A
W
QV
I
G
G
Y
---
T
Q
Q
K
A
T
IKNG
K
D
VAQDG
S
S
S
LP
YT
PE
H
AFT
L
WSQY
QA
TD
D
I
S
V
G
AGA
R
Y
I
G
S--
-
---
-
M
H
KG
SDGAV
G
TPAFTE
G
-
Y
WVA
D
A
K
LG
Y
R
V
N
R
NL
D
FQLN
V
Y
NLFD
-
-
-
------
-
-
-
-
---
-
T
D
YVA
SI
N
KSG
Y
R
Y
H
PG
EP
RT
FL
L
TA
N
M
HF
fig|83333.1.peg.791
Escherichia coli K12 (10-760/760)
RQF
HSLT
FFAG
L
-
CI
G
IT
-
P
V
A
Q
A
LA
A
E
GQTNA
DDTLVV
E
A
-
S
T
P
SL
-
Y
AP
QQ
S
ADP
KFSRPVADTTRTM
TV
I
S
EQVI
KD
Q
GAT
NLT
D
AL
K
N
V
PGV
G
A
FFA
GE
N
GNST
T
G
D
-----
A
I
Y
M
RG
ADTS
N
S-
------
IYIDG
-
-
IR
D
I
G
SV
----
--S
RDT
FN
---------
T
E
Q
VEV
IK
GP
S
GT
D
YG
R
SA
P
T
G
S
IN
M
I
S
KQP
RN---
-
--
D
S
G
I
D
A
SA
S
IGSAWFR
R
GT
L
D
V
N
QV
I
-
GD
TTAV
RL
NV
MGE
--
KT
H
D
-
---
--
-
--
-
-----
---------
AGR
DK
V
K
N
E
-----
-
R
YGV
AP
--
S
VAFGL
G
TANRLY
L
N
Y
LHV
TQ
HNTP
D
GGIPTIGLPGYSAPS
AG
T
AA
LN
HS
G
K
V
D
T
HNF
Y
GT
--
-
---
D
SD
Y
D
D
S
T
T
D
T
ATMRF
EH
DINDNTTIRNT
TR
W
SR
VK
QD
YLMT
A
IM
G
-----
G
ASNITQPT
S
-------
D
V
N
S
W
T
W
S
RTA
NT
K
D
VSNKI
L
T
--
NQT
NLTS
TF
YT
GS
IG
HDV
S
T
G
V
E
FTR
E
T
Q
TNYGV
N
PVT
L
PAV
N
I
YHP
DSS
I
HP
G
GL
T
R
NG
------------------
A
N
A
N
GQ
TD
TFA
I
YA
FD
T
LQ
I
T
R
D
F
E
L
N
GG
I
R
L
D
-
-
-----
NYH
TEYDSATAC
G
G
S
G
RGAI
T
CPT
G
V
A
KG
SPVTTVDTAKSGNL
M
N
W
KA
G
ALY
H
LT
E
N
GN
V
YI
N
YA
VSQQ
P
P
G
G
N
NF
A
LA
Q
S
G
SGNSANRT
DFK
PQ
K
ANT
S
EIGT
KWQ
VL
D
K
R
L
L
LT
A
A
L
FR
T
D
IE
N
EV
E
-
-
-
-
--
-
QN
DD
GT
----
Y
S
Q
Y
GK
K
R
VEG
Y
E
I
S
VAGNIT
P
----
--A
W
QV
I
G
G
Y
---
T
Q
Q
K
A
T
IKNG
K
D
VAQDG
S
S
S
LP
YT
PE
H
AFT
L
WSQY
QA
TD
D
I
S
V
G
AGA
R
Y
I
G
S--
-
---
-
M
H
KG
SDGAV
G
TPAFTE
G
-
Y
WVA
D
A
K
LG
Y
R
V
N
R
NL
D
FQLN
V
Y
NLFD
-
-
-
------
-
-
-
-
---
-
T
D
YVA
SI
N
KSG
Y
R
Y
H
PG
EP
RT
FL
L
TA
N
M
HF
fig|749537.3.peg.3550
Escherichia coli MS 115-1 (10-760/760)
RQF
HSLT
FFAG
L
-
CI
G
IT
-
P
V
A
Q
A
LA
A
E
GQTNA
DDTLVV
E
A
-
S
T
P
SL
-
Y
AP
QQ
S
ADP
KFSRPVADTTRTM
TV
I
S
EQVI
KD
Q
GAT
NLT
D
AL
K
N
V
PGV
G
A
FFA
GE
N
GNST
T
G
D
-----
A
I
Y
M
RG
ADTS
N
S-
------
IYIDG
-
-
IR
D
I
G
SV
----
--S
RDT
FN
---------
T
E
Q
VEV
IK
GP
S
GT
D
YG
R
SA
P
T
G
S
IN
M
I
S
KQP
RN---
-
--
D
S
G
I
D
A
SA
S
IGSAWFR
R
GT
L
D
V
N
QV
I
-
GD
TTAV
RL
NV
MGE
--
KT
H
D
-
---
--
-
--
-
-----
---------
AGR
DK
V
K
N
E
-----
-
R
YGV
AP
--
S
VAFGL
G
TANRLY
L
N
Y
LHV
TQ
HNTP
D
GGIPTIGLPGYSAPS
AG
T
AA
LN
HS
G
K
V
D
T
HNF
Y
GT
--
-
---
D
SD
Y
D
D
S
T
T
D
T
ATMRF
EH
DINDNTTIRNT
TR
W
SR
VK
QD
YLMT
A
IM
G
-----
G
ASNITQPT
S
-------
D
V
N
S
W
T
W
S
RTA
NT
K
D
VSNKI
L
T
--
NQT
NLTS
TF
YT
GS
IG
HDV
S
T
G
V
E
FTR
E
T
Q
TNYGV
N
PVT
L
PAV
N
I
YHP
DSS
I
HP
G
GL
T
R
NG
------------------
A
N
A
N
GQ
TD
TFA
I
YA
FD
T
LQ
I
T
R
D
F
E
L
N
GG
I
R
L
D
-
-
-----
NYH
TEYDSATAC
G
G
S
G
RGAI
T
CPT
G
V
A
KG
SPVTTVDTAKSGNL
M
N
W
KA
G
ALY
H
LT
E
N
GN
V
YI
N
YA
VSQQ
P
P
G
G
N
NF
A
LA
Q
S
G
SGNSANRT
DFK
PQ
K
ANT
S
EIGT
KWQ
VL
D
K
R
L
L
LT
A
A
L
FR
T
D
IE
N
EV
E
-
-
-
-
--
-
QN
DD
GT
----
Y
S
Q
Y
GK
K
R
VEG
Y
E
I
S
VAGNIT
P
----
--A
W
QV
I
G
G
Y
---
T
Q
Q
K
A
T
IKNG
K
D
VAQDG
S
S
S
LP
YT
PE
H
AFT
L
WSQY
QA
TD
D
I
S
V
G
AGA
R
Y
I
G
S--
-
---
-
M
H
KG
SDGAV
G
TPAFTE
G
-
Y
WVA
D
A
K
LG
Y
R
V
N
R
NL
D
FQLN
V
Y
NLFD
-
-
-
------
-
-
-
-
---
-
T
D
YVA
SI
N
KSG
Y
R
Y
H
PG
EP
RT
FL
L
TA
N
M
HF
fig|749538.3.peg.727
Escherichia coli MS 116-1 (10-760/760)
RQF
HSLT
FFAG
L
-
CI
G
IT
-
P
V
A
Q
A
LA
A
E
GQTNA
DDTLVV
E
A
-
S
T
P
SL
-
Y
AP
QQ
S
ADP
KFSRPVADTTRTM
TV
I
S
EQVI
KD
Q
GAT
NLT
D
AL
K
N
V
PGV
G
A
FFA
GE
N
GNST
T
G
D
-----
A
I
Y
M
RG
ADTS
N
S-
------
IYIDG
-
-
IR
D
I
G
SV
----
--S
RDT
FN
---------
T
E
Q
VEV
IK
GP
S
GT
D
YG
R
SA
P
T
G
S
IN
M
I
S
KQP
RN---
-
--
D
S
G
I
D
A
SA
S
IGSAWFR
R
GT
L
D
V
N
QV
I
-
GD
TTAV
RL
NV
MGE
--
KT
H
D
-
---
--
-
--
-
-----
---------
AGR
DK
V
K
N
E
-----
-
R
YGV
AP
--
S
VAFGL
G
TANRLY
L
N
Y
LHV
TQ
HNTP
D
GGIPTIGLPGYSAPS
AG
T
AA
LN
HS
G
K
V
D
T
HNF
Y
GT
--
-
---
D
SD
Y
D
D
S
T
T
D
T
ATMRF
EH
DINDNTTIRNT
TR
W
SR
VK
QD
YLMT
A
IM
G
-----
G
ASNITQPT
S
-------
D
V
N
S
W
T
W
S
RTA
NT
K
D
VSNKI
L
T
--
NQT
NLTS
TF
YT
GS
IG
HDV
S
T
G
V
E
FTR
E
T
Q
TNYGV
N
PVT
L
PAV
N
I
YHP
DSS
I
HP
G
GL
T
R
NG
------------------
A
N
A
N
GQ
TD
TFA
I
YA
FD
T
LQ
I
T
R
D
F
E
L
N
GG
I
R
L
D
-
-
-----
NYH
TEYDSATAC
G
G
S
G
RGAI
T
CPT
G
V
A
KG
SPVTTVDTAKSGNL
M
N
W
KA
G
ALY
H
LT
E
N
GN
V
YI
N
YA
VSQQ
P
P
G
G
N
NF
A
LA
Q
S
G
SGNSANRT
DFK
PQ
K
ANT
S
EIGT
KWQ
VL
D
K
R
L
L
LT
A
A
L
FR
T
D
IE
N
EV
E
-
-
-
-
--
-
QN
DD
GT
----
Y
S
Q
Y
GK
K
R
VEG
Y
E
I
S
VAGNIT
P
----
--A
W
QV
I
G
G
Y
---
T
Q
Q
K
A
T
IKNG
K
D
VAQDG
S
S
S
LP
YT
PE
H
AFT
L
WSQY
QA
TD
D
I
S
V
G
AGA
R
Y
I
G
S--
-
---
-
M
H
KG
SDGAV
G
TPAFTE
G
-
Y
WVA
D
A
K
LG
Y
R
V
N
R
NL
D
FQLN
V
Y
NLFD
-
-
-
------
-
-
-
-
---
-
T
D
YVA
SI
N
KSG
Y
R
Y
H
PG
EP
RT
FL
L
TA
N
M
HF
fig|679205.4.peg.2075
Escherichia coli MS 124-1 (10-760/760)
RQF
HSLT
FFAG
L
-
CI
G
IT
-
P
V
A
Q
A
LA
A
E
GQTNA
DDTLVV
E
A
-
S
T
P
SL
-
Y
AP
QQ
S
ADP
KFSRPVADTTRTM
TV
I
S
EQVI
KD
Q
GAT
NLT
D
AL
K
N
V
PGV
G
A
FFA
GE
N
GNST
T
G
D
-----
A
I
Y
M
RG
ADTS
N
S-
------
IYIDG
-
-
IR
D
I
G
SV
----
--S
RDT
FN
---------
T
E
Q
VEV
IK
GP
S
GT
D
YG
R
SA
P
T
G
S
IN
M
I
S
KQP
RN---
-
--
D
S
G
I
D
A
SA
S
IGSAWFR
R
GT
L
D
V
N
QV
I
-
GD
TTAV
RL
NV
MGE
--
KT
H
D
-
---
--
-
--
-
-----
---------
AGR
DK
V
K
N
E
-----
-
R
YGV
AP
--
S
VAFGL
G
TANRLY
L
N
Y
LHV
TQ
HNTP
D
GGIPTIGLPGYSAPS
AG
T
AA
LN
HS
G
K
V
D
T
HNF
Y
GT
--
-
---
D
SD
Y
D
D
S
T
T
D
T
ATMRF
EH
DINDNTTIRNT
TR
W
SR
VK
QD
YLMT
A
IM
G
-----
G
ASNITQPT
S
-------
D
V
N
S
W
T
W
S
RTA
NT
K
D
VSNKI
L
T
--
NQT
NLTS
TF
YT
GS
IG
HDV
S
T
G
V
E
FTR
E
T
Q
TNYGV
N
PVT
L
PAV
N
I
YHP
DSS
I
HP
G
GL
T
R
NG
------------------
A
N
A
N
GQ
TD
TFA
I
YA
FD
T
LQ
I
T
R
D
F
E
L
N
GG
I
R
L
D
-
-
-----
NYH
TEYDSATAC
G
G
S
G
RGAI
T
CPT
G
V
A
KG
SPVTTVDTAKSGNL
M
N
W
KA
G
ALY
H
LT
E
N
GN
V
YI
N
YA
VSQQ
P
P
G
G
N
NF
A
LA
Q
S
G
SGNSANRT
DFK
PQ
K
ANT
S
EIGT
KWQ
VL
D
K
R
L
L
LT
A
A
L
FR
T
D
IE
N
EV
E
-
-
-
-
--
-
QN
DD
GT
----
Y
S
Q
Y
GK
K
R
VEG
Y
E
I
S
VAGNIT
P
----
--A
W
QV
I
G
G
Y
---
T
Q
Q
K
A
T
IKNG
K
D
VAQDG
S
S
S
LP
YT
PE
H
AFT
L
WSQY
QA
TD
D
I
S
V
G
AGA
R
Y
I
G
S--
-
---
-
M
H
KG
SDGAV
G
TPAFTE
G
-
Y
WVA
D
A
K
LG
Y
R
V
N
R
NL
D
FQLN
V
Y
NLFD
-
-
-
------
-
-
-
-
---
-
T
D
YVA
SI
N
KSG
Y
R
Y
H
PG
EP
RT
FL
L
TA
N
M
HF
fig|749540.3.peg.2741
Escherichia coli MS 146-1 (10-760/760)
RQF
HSLT
FFAG
L
-
CI
G
IT
-
P
V
A
Q
A
LA
A
E
GQTNA
DDTLVV
E
A
-
S
T
P
SL
-
Y
AP
QQ
S
ADP
KFSRPVADTTRTM
TV
I
S
EQVI
KD
Q
GAT
NLT
D
AL
K
N
V
PGV
G
A
FFA
GE
N
GNST
T
G
D
-----
A
I
Y
M
RG
ADTS
N
S-
------
IYIDG
-
-
IR
D
I
G
SV
----
--S
RDT
FN
---------
T
E
Q
VEV
IK
GP
S
GT
D
YG
R
SA
P
T
G
S
IN
M
I
S
KQP
RN---
-
--
D
S
G
I
D
A
SA
S
IGSAWFR
R
GT
L
D
V
N
QV
I
-
GD
TTAV
RL
NV
MGE
--
KT
H
D
-
---
--
-
--
-
-----
---------
AGR
DK
V
K
N
E
-----
-
R
YGV
AP
--
S
VAFGL
G
TANRLY
L
N
Y
LHV
TQ
HNTP
D
GGIPTIGLPGYSAPS
AG
T
AA
LN
HS
G
K
V
D
T
HNF
Y
GT
--
-
---
D
SD
Y
D
D
S
T
T
D
T
ATMRF
EH
DINDNTTIRNT
TR
W
SR
VK
QD
YLMT
A
IM
G
-----
G
ASNITQPT
S
-------
D
V
N
S
W
T
W
S
RTA
NT
K
D
VSNKI
L
T
--
NQT
NLTS
TF
YT
GS
IG
HDV
S
T
G
V
E
FTR
E
T
Q
TNYGV
N
PVT
L
PAV
N
I
YHP
DSS
I
HP
G
GL
T
R
NG
------------------
A
N
A
N
GQ
TD
TFA
I
YA
FD
T
LQ
I
T
R
D
F
E
L
N
GG
I
R
L
D
-
-
-----
NYH
TEYDSATAC
G
G
S
G
RGAI
T
CPT
G
V
A
KG
SPVTTVDTAKSGNL
M
N
W
KA
G
ALY
H
LT
E
N
GN
V
YI
N
YA
VSQQ
P
P
G
G
N
NF
A
LA
Q
S
G
SGNSANRT
DFK
PQ
K
ANT
S
EIGT
KWQ
VL
D
K
R
L
L
LT
A
A
L
FR
T
D
IE
N
EV
E
-
-
-
-
--
-
QN
DD
GT
----
Y
S
Q
Y
GK
K
R
VEG
Y
E
I
S
VAGNIT
P
----
--A
W
QV
I
G
G
Y
---
T
Q
Q
K
A
T
IKNG
K
D
VAQDG
S
S
S
LP
YT
PE
H
AFT
L
WSQY
QA
TD
D
I
S
V
G
AGA
R
Y
I
G
S--
-
---
-
M
H
KG
SDGAV
G
TPAFTE
G
-
Y
WVA
D
A
K
LG
Y
R
V
N
R
NL
D
FQLN
V
Y
NLFD
-
-
-
------
-
-
-
-
---
-
T
D
YVA
SI
N
KSG
Y
R
Y
H
PG
EP
RT
FL
L
TA
N
M
HF
fig|749544.3.peg.2689
Escherichia coli MS 175-1 (10-760/760)
RQF
HSLT
FFAG
L
-
CI
G
IT
-
P
V
A
Q
A
LA
A
E
GQTNA
DDTLVV
E
A
-
S
T
P
SL
-
Y
AP
QQ
S
ADP
KFSRPVADTTRTM
TV
I
S
EQVI
KD
Q
GAT
NLT
D
AL
K
N
V
PGV
G
A
FFA
GE
N
GNST
T
G
D
-----
A
I
Y
M
RG
ADTS
N
S-
------
IYIDG
-
-
IR
D
I
G
SV
----
--S
RDT
FN
---------
T
E
Q
VEV
IK
GP
S
GT
D
YG
R
SA
P
T
G
S
IN
M
I
S
KQP
RN---
-
--
D
S
G
I
D
A
SA
S
IGSAWFR
R
GT
L
D
V
N
QV
I
-
GD
TTAV
RL
NV
MGE
--
KT
H
D
-
---
--
-
--
-
-----
---------
AGR
DK
V
K
N
E
-----
-
R
YGV
AP
--
S
VAFGL
G
TANRLY
L
N
Y
LHV
TQ
HNTP
D
GGIPTIGLPGYSAPS
AG
T
AA
LN
HS
G
K
V
D
T
HNF
Y
GT
--
-
---
D
SD
Y
D
D
S
T
T
D
T
ATMRF
EH
DINDNTTIRNT
TR
W
SR
VK
QD
YLMT
A
IM
G
-----
G
ASNITQPT
S
-------
D
V
N
S
W
T
W
S
RTA
NT
K
D
VSNKI
L
T
--
NQT
NLTS
TF
YT
GS
IG
HDV
S
T
G
V
E
FTR
E
T
Q
TNYGV
N
PVT
L
PAV
N
I
YHP
DSS
I
HP
G
GL
T
R
NG
------------------
A
N
A
N
GQ
TD
TFA
I
YA
FD
T
LQ
I
T
R
D
F
E
L
N
GG
I
R
L
D
-
-
-----
NYH
TEYDSATAC
G
G
S
G
RGAI
T
CPT
G
V
A
KG
SPVTTVDTAKSGNL
M
N
W
KA
G
ALY
H
LT
E
N
GN
V
YI
N
YA
VSQQ
P
P
G
G
N
NF
A
LA
Q
S
G
SGNSANRT
DFK
PQ
K
ANT
S
EIGT
KWQ
VL
D
K
R
L
L
LT
A
A
L
FR
T
D
IE
N
EV
E
-
-
-
-
--
-
QN
DD
GT
----
Y
S
Q
Y
GK
K
R
VEG
Y
E
I
S
VAGNIT
P
----
--A
W
QV
I
G
G
Y
---
T
Q
Q
K
A
T
IKNG
K
D
VAQDG
S
S
S
LP
YT
PE
H
AFT
L
WSQY
QA
TD
D
I
S
V
G
AGA
R
Y
I
G
S--
-
---
-
M
H
KG
SDGAV
G
TPAFTE
G
-
Y
WVA
D
A
K
LG
Y
R
V
N
R
NL
D
FQLN
V
Y
NLFD
-
-
-
------
-
-
-
-
---
-
T
D
YVA
SI
N
KSG
Y
R
Y
H
PG
EP
RT
FL
L
TA
N
M
HF
fig|749533.3.peg.4816
Escherichia coli MS 84-1 (10-760/760)
RQF
HSLT
FFAG
L
-
CI
G
IT
-
P
V
A
Q
A
LA
A
E
GQTNA
DDTLVV
E
A
-
S
T
P
SL
-
Y
AP
QQ
S
ADP
KFSRPVADTTRTM
TV
I
S
EQVI
KD
Q
GAT
NLT
D
AL
K
N
V
PGV
G
A
FFA
GE
N
GNST
T
G
D
-----
A
I
Y
M
RG
ADTS
N
S-
------
IYIDG
-
-
IR
D
I
G
SV
----
--S
RDT
FN
---------
T
E
Q
VEV
IK
GP
S
GT
D
YG
R
SA
P
T
G
S
IN
M
I
S
KQP
RN---
-
--
D
S
G
I
D
A
SA
S
IGSAWFR
R
GT
L
D
V
N
QV
I
-
GD
TTAV
RL
NV
MGE
--
KT
H
D
-
---
--
-
--
-
-----
---------
AGR
DK
V
K
N
E
-----
-
R
YGV
AP
--
S
VAFGL
G
TANRLY
L
N
Y
LHV
TQ
HNTP
D
GGIPTIGLPGYSAPS
AG
T
AA
LN
HS
G
K
V
D
T
HNF
Y
GT
--
-
---
D
SD
Y
D
D
S
T
T
D
T
ATMRF
EH
DINDNTTIRNT
TR
W
SR
VK
QD
YLMT
A
IM
G
-----
G
ASNITQPT
S
-------
D
V
N
S
W
T
W
S
RTA
NT
K
D
VSNKI
L
T
--
NQT
NLTS
TF
YT
GS
IG
HDV
S
T
G
V
E
FTR
E
T
Q
TNYGV
N
PVT
L
PAV
N
I
YHP
DSS
I
HP
G
GL
T
R
NG
------------------
A
N
A
N
GQ
TD
TFA
I
YA
FD
T
LQ
I
T
R
D
F
E
L
N
GG
I
R
L
D
-
-
-----
NYH
TEYDSATAC
G
G
S
G
RGAI
T
CPT
G
V
A
KG
SPVTTVDTAKSGNL
M
N
W
KA
G
ALY
H
LT
E
N
GN
V
YI
N
YA
VSQQ
P
P
G
G
N
NF
A
LA
Q
S
G
SGNSANRT
DFK
PQ
K
ANT
S
EIGT
KWQ
VL
D
K
R
L
L
LT
A
A
L
FR
T
D
IE
N
EV
E
-
-
-
-
--
-
QN
DD
GT
----
Y
S
Q
Y
GK
K
R
VEG
Y
E
I
S
VAGNIT
P
----
--A
W
QV
I
G
G
Y
---
T
Q
Q
K
A
T
IKNG
K
D
VAQDG
S
S
S
LP
YT
PE
H
AFT
L
WSQY
QA
TD
D
I
S
V
G
AGA
R
Y
I
G
S--
-
---
-
M
H
KG
SDGAV
G
TPAFTE
G
-
Y
WVA
D
A
K
LG
Y
R
V
N
R
NL
D
FQLN
V
Y
NLFD
-
-
-
------
-
-
-
-
---
-
T
D
YVA
SI
N
KSG
Y
R
Y
H
PG
EP
RT
FL
L
TA
N
M
HF
fig|316407.3.peg.772
Escherichia coli W3110 (10-760/760)
RQF
HSLT
FFAG
L
-
CI
G
IT
-
P
V
A
Q
A
LA
A
E
GQTNA
DDTLVV
E
A
-
S
T
P
SL
-
Y
AP
QQ
S
ADP
KFSRPVADTTRTM
TV
I
S
EQVI
KD
Q
GAT
NLT
D
AL
K
N
V
PGV
G
A
FFA
GE
N
GNST
T
G
D
-----
A
I
Y
M
RG
ADTS
N
S-
------
IYIDG
-
-
IR
D
I
G
SV
----
--S
RDT
FN
---------
T
E
Q
VEV
IK
GP
S
GT
D
YG
R
SA
P
T
G
S
IN
M
I
S
KQP
RN---
-
--
D
S
G
I
D
A
SA
S
IGSAWFR
R
GT
L
D
V
N
QV
I
-
GD
TTAV
RL
NV
MGE
--
KT
H
D
-
---
--
-
--
-
-----
---------
AGR
DK
V
K
N
E
-----
-
R
YGV
AP
--
S
VAFGL
G
TANRLY
L
N
Y
LHV
TQ
HNTP
D
GGIPTIGLPGYSAPS
AG
T
AA
LN
HS
G
K
V
D
T
HNF
Y
GT
--
-
---
D
SD
Y
D
D
S
T
T
D
T
ATMRF
EH
DINDNTTIRNT
TR
W
SR
VK
QD
YLMT
A
IM
G
-----
G
ASNITQPT
S
-------
D
V
N
S
W
T
W
S
RTA
NT
K
D
VSNKI
L
T
--
NQT
NLTS
TF
YT
GS
IG
HDV
S
T
G
V
E
FTR
E
T
Q
TNYGV
N
PVT
L
PAV
N
I
YHP
DSS
I
HP
G
GL
T
R
NG
------------------
A
N
A
N
GQ
TD
TFA
I
YA
FD
T
LQ
I
T
R
D
F
E
L
N
GG
I
R
L
D
-
-
-----
NYH
TEYDSATAC
G
G
S
G
RGAI
T
CPT
G
V
A
KG
SPVTTVDTAKSGNL
M
N
W
KA
G
ALY
H
LT
E
N
GN
V
YI
N
YA
VSQQ
P
P
G
G
N
NF
A
LA
Q
S
G
SGNSANRT
DFK
PQ
K
ANT
S
EIGT
KWQ
VL
D
K
R
L
L
LT
A
A
L
FR
T
D
IE
N
EV
E
-
-
-
-
--
-
QN
DD
GT
----
Y
S
Q
Y
GK
K
R
VEG
Y
E
I
S
VAGNIT
P
----
--A
W
QV
I
G
G
Y
---
T
Q
Q
K
A
T
IKNG
K
D
VAQDG
S
S
S
LP
YT
PE
H
AFT
L
WSQY
QA
TD
D
I
S
V
G
AGA
R
Y
I
G
S--
-
---
-
M
H
KG
SDGAV
G
TPAFTE
G
-
Y
WVA
D
A
K
LG
Y
R
V
N
R
NL
D
FQLN
V
Y
NLFD
-
-
-
------
-
-
-
-
---
-
T
D
YVA
SI
N
KSG
Y
R
Y
H
PG
EP
RT
FL
L
TA
N
M
HF
fig|316385.7.peg.881
Escherichia coli str. K-12 substr. DH10B (10-760/760)
RQF
HSLT
FFAG
L
-
CI
G
IT
-
P
V
A
Q
A
LA
A
E
GQTNA
DDTLVV
E
A
-
S
T
P
SL
-
Y
AP
QQ
S
ADP
KFSRPVADTTRTM
TV
I
S
EQVI
KD
Q
GAT
NLT
D
AL
K
N
V
PGV
G
A
FFA
GE
N
GNST
T
G
D
-----
A
I
Y
M
RG
ADTS
N
S-
------
IYIDG
-
-
IR
D
I
G
SV
----
--S
RDT
FN
---------
T
E
Q
VEV
IK
GP
S
GT
D
YG
R
SA
P
T
G
S
IN
M
I
S
KQP
RN---
-
--
D
S
G
I
D
A
SA
S
IGSAWFR
R
GT
L
D
V
N
QV
I
-
GD
TTAV
RL
NV
MGE
--
KT
H
D
-
---
--
-
--
-
-----
---------
AGR
DK
V
K
N
E
-----
-
R
YGV
AP
--
S
VAFGL
G
TANRLY
L
N
Y
LHV
TQ
HNTP
D
GGIPTIGLPGYSAPS
AG
T
AA
LN
HS
G
K
V
D
T
HNF
Y
GT
--
-
---
D
SD
Y
D
D
S
T
T
D
T
ATMRF
EH
DINDNTTIRNT
TR
W
SR
VK
QD
YLMT
A
IM
G
-----
G
ASNITQPT
S
-------
D
V
N
S
W
T
W
S
RTA
NT
K
D
VSNKI
L
T
--
NQT
NLTS
TF
YT
GS
IG
HDV
S
T
G
V
E
FTR
E
T
Q
TNYGV
N
PVT
L
PAV
N
I
YHP
DSS
I
HP
G
GL
T
R
NG
------------------
A
N
A
N
GQ
TD
TFA
I
YA
FD
T
LQ
I
T
R
D
F
E
L
N
GG
I
R
L
D
-
-
-----
NYH
TEYDSATAC
G
G
S
G
RGAI
T
CPT
G
V
A
KG
SPVTTVDTAKSGNL
M
N
W
KA
G
ALY
H
LT
E
N
GN
V
YI
N
YA
VSQQ
P
P
G
G
N
NF
A
LA
Q
S
G
SGNSANRT
DFK
PQ
K
ANT
S
EIGT
KWQ
VL
D
K
R
L
L
LT
A
A
L
FR
T
D
IE
N
EV
E
-
-
-
-
--
-
QN
DD
GT
----
Y
S
Q
Y
GK
K
R
VEG
Y
E
I
S
VAGNIT
P
----
--A
W
QV
I
G
G
Y
---
T
Q
Q
K
A
T
IKNG
K
D
VAQDG
S
S
S
LP
YT
PE
H
AFT
L
WSQY
QA
TD
D
I
S
V
G
AGA
R
Y
I
G
S--
-
---
-
M
H
KG
SDGAV
G
TPAFTE
G
-
Y
WVA
D
A
K
LG
Y
R
V
N
R
NL
D
FQLN
V
Y
NLFD
-
-
-
------
-
-
-
-
---
-
T
D
YVA
SI
N
KSG
Y
R
Y
H
PG
EP
RT
FL
L
TA
N
M
HF
fig|511145.12.peg.832
Escherichia coli str. K-12 substr. MG1655 (10-760/760)
RQF
HSLT
FFAG
L
-
CI
G
IT
-
P
V
A
Q
A
LA
A
E
GQTNA
DDTLVV
E
A
-
S
T
P
SL
-
Y
AP
QQ
S
ADP
KFSRPVADTTRTM
TV
I
S
EQVI
KD
Q
GAT
NLT
D
AL
K
N
V
PGV
G
A
FFA
GE
N
GNST
T
G
D
-----
A
I
Y
M
RG
ADTS
N
S-
------
IYIDG
-
-
IR
D
I
G
SV
----
--S
RDT
FN
---------
T
E
Q
VEV
IK
GP
S
GT
D
YG
R
SA
P
T
G
S
IN
M
I
S
KQP
RN---
-
--
D
S
G
I
D
A
SA
S
IGSAWFR
R
GT
L
D
V
N
QV
I
-
GD
TTAV
RL
NV
MGE
--
KT
H
D
-
---
--
-
--
-
-----
---------
AGR
DK
V
K
N
E
-----
-
R
YGV
AP
--
S
VAFGL
G
TANRLY
L
N
Y
LHV
TQ
HNTP
D
GGIPTIGLPGYSAPS
AG
T
AA
LN
HS
G
K
V
D
T
HNF
Y
GT
--
-
---
D
SD
Y
D
D
S
T
T
D
T
ATMRF
EH
DINDNTTIRNT
TR
W
SR
VK
QD
YLMT
A
IM
G
-----
G
ASNITQPT
S
-------
D
V
N
S
W
T
W
S
RTA
NT
K
D
VSNKI
L
T
--
NQT
NLTS
TF
YT
GS
IG
HDV
S
T
G
V
E
FTR
E
T
Q
TNYGV
N
PVT
L
PAV
N
I
YHP
DSS
I
HP
G
GL
T
R
NG
------------------
A
N
A
N
GQ
TD
TFA
I
YA
FD
T
LQ
I
T
R
D
F
E
L
N
GG
I
R
L
D
-
-
-----
NYH
TEYDSATAC
G
G
S
G
RGAI
T
CPT
G
V
A
KG
SPVTTVDTAKSGNL
M
N
W
KA
G
ALY
H
LT
E
N
GN
V
YI
N
YA
VSQQ
P
P
G
G
N
NF
A
LA
Q
S
G
SGNSANRT
DFK
PQ
K
ANT
S
EIGT
KWQ
VL
D
K
R
L
L
LT
A
A
L
FR
T
D
IE
N
EV
E
-
-
-
-
--
-
QN
DD
GT
----
Y
S
Q
Y
GK
K
R
VEG
Y
E
I
S
VAGNIT
P
----
--A
W
QV
I
G
G
Y
---
T
Q
Q
K
A
T
IKNG
K
D
VAQDG
S
S
S
LP
YT
PE
H
AFT
L
WSQY
QA
TD
D
I
S
V
G
AGA
R
Y
I
G
S--
-
---
-
M
H
KG
SDGAV
G
TPAFTE
G
-
Y
WVA
D
A
K
LG
Y
R
V
N
R
NL
D
FQLN
V
Y
NLFD
-
-
-
------
-
-
-
-
---
-
T
D
YVA
SI
N
KSG
Y
R
Y
H
PG
EP
RT
FL
L
TA
N
M
HF
fig|511145.6.peg.824
Escherichia coli str. K-12 substr. MG1655 (10-760/760)
RQF
HSLT
FFAG
L
-
CI
G
IT
-
P
V
A
Q
A
LA
A
E
GQTNA
DDTLVV
E
A
-
S
T
P
SL
-
Y
AP
QQ
S
ADP
KFSRPVADTTRTM
TV
I
S
EQVI
KD
Q
GAT
NLT
D
AL
K
N
V
PGV
G
A
FFA
GE
N
GNST
T
G
D
-----
A
I
Y
M
RG
ADTS
N
S-
------
IYIDG
-
-
IR
D
I
G
SV
----
--S
RDT
FN
---------
T
E
Q
VEV
IK
GP
S
GT
D
YG
R
SA
P
T
G
S
IN
M
I
S
KQP
RN---
-
--
D
S
G
I
D
A
SA
S
IGSAWFR
R
GT
L
D
V
N
QV
I
-
GD
TTAV
RL
NV
MGE
--
KT
H
D
-
---
--
-
--
-
-----
---------
AGR
DK
V
K
N
E
-----
-
R
YGV
AP
--
S
VAFGL
G
TANRLY
L
N
Y
LHV
TQ
HNTP
D
GGIPTIGLPGYSAPS
AG
T
AA
LN
HS
G
K
V
D
T
HNF
Y
GT
--
-
---
D
SD
Y
D
D
S
T
T
D
T
ATMRF
EH
DINDNTTIRNT
TR
W
SR
VK
QD
YLMT
A
IM
G
-----
G
ASNITQPT
S
-------
D
V
N
S
W
T
W
S
RTA
NT
K
D
VSNKI
L
T
--
NQT
NLTS
TF
YT
GS
IG
HDV
S
T
G
V
E
FTR
E
T
Q
TNYGV
N
PVT
L
PAV
N
I
YHP
DSS
I
HP
G
GL
T
R
NG
------------------
A
N
A
N
GQ
TD
TFA
I
YA
FD
T
LQ
I
T
R
D
F
E
L
N
GG
I
R
L
D
-
-
-----
NYH
TEYDSATAC
G
G
S
G
RGAI
T
CPT
G
V
A
KG
SPVTTVDTAKSGNL
M
N
W
KA
G
ALY
H
LT
E
N
GN
V
YI
N
YA
VSQQ
P
P
G
G
N
NF
A
LA
Q
S
G
SGNSANRT
DFK
PQ
K
ANT
S
EIGT
KWQ
VL
D
K
R
L
L
LT
A
A
L
FR
T
D
IE
N
EV
E
-
-
-
-
--
-
QN
DD
GT
----
Y
S
Q
Y
GK
K
R
VEG
Y
E
I
S
VAGNIT
P
----
--A
W
QV
I
G
G
Y
---
T
Q
Q
K
A
T
IKNG
K
D
VAQDG
S
S
S
LP
YT
PE
H
AFT
L
WSQY
QA
TD
D
I
S
V
G
AGA
R
Y
I
G
S--
-
---
-
M
H
KG
SDGAV
G
TPAFTE
G
-
Y
WVA
D
A
K
LG
Y
R
V
N
R
NL
D
FQLN
V
Y
NLFD
-
-
-
------
-
-
-
-
---
-
T
D
YVA
SI
N
KSG
Y
R
Y
H
PG
EP
RT
FL
L
TA
N
M
HF
fig|344601.3.peg.2534
Escherichia coli B171 (10-760/760)
RQF
HSLT
FFAG
L
-
CI
G
IT
-
P
V
A
Q
A
LA
A
E
GQTNA
DDTLVV
E
A
-
S
T
P
SL
-
Y
AP
QQ
S
ADP
KFSRPVADTTRTM
TV
I
S
EQVI
KD
Q
GAT
NLT
D
AL
K
N
V
PGV
G
A
FFA
GE
N
GNST
T
G
D
-----
A
I
Y
M
RG
ADTS
N
S-
------
IYIDG
-
-
IR
D
I
G
SV
----
--S
RDT
FN
---------
T
E
Q
VEV
IK
GP
S
GT
D
YG
R
SA
P
T
G
S
IN
M
I
S
KQP
RN---
-
--
D
S
G
I
D
A
SA
S
IGSAWFR
R
GT
L
D
V
N
QV
I
-
GD
TTAV
RL
NV
MGE
--
KT
H
D
-
---
--
-
--
-
-----
---------
AGR
DK
V
K
N
E
-----
-
R
YGV
AP
--
S
IAFGL
G
TANRLY
L
N
Y
LHV
TQ
HNTP
D
GGIPTIGLPGYSAPS
AG
T
AA
LN
HS
G
K
V
D
T
HNF
Y
GT
--
-
---
D
SD
Y
D
D
S
T
T
D
T
ATMRF
EH
DINDNTTIRNT
TR
W
SR
VK
QD
YLMT
A
IM
G
-----
G
ASNITQPT
S
-------
D
V
N
S
W
T
W
S
RTA
NT
K
D
VSNKI
L
T
--
NQT
NLTS
TF
YT
GS
IG
HDV
S
T
G
V
E
FTR
E
T
Q
TNYGV
N
PVT
L
PAV
N
I
YHP
DSS
I
HP
G
GL
T
R
NG
------------------
A
N
A
N
GQ
TD
TFA
I
YA
FD
T
LQ
I
T
R
D
F
E
L
N
GG
I
R
L
D
-
-
-----
NYH
TEYDSATAC
G
G
S
G
RGAI
T
CPA
G
V
A
KG
SPVTTVDTAKSGNLVN
W
KA
G
ALY
H
LT
E
N
GN
V
YI
N
YA
VSQQ
P
P
G
G
N
NF
A
LA
Q
S
G
SGNSANRT
DFK
PQ
K
ANT
S
EIGT
KWQ
VL
D
K
R
L
L
LT
A
A
L
FR
T
D
IE
N
EV
E
-
-
-
-
--
-
QN
DD
GT
----
Y
S
Q
Y
GK
K
R
VEG
Y
E
I
S
VAGNIT
P
----
--A
W
QV
I
G
G
Y
---
T
Q
Q
K
A
T
IKNG
K
D
VAQDG
S
S
S
LP
YT
PE
H
AFT
L
WSQY
QA
TD
D
I
S
V
G
AGA
R
Y
I
G
S--
-
---
-
M
H
KG
SDGAV
G
TPAFTE
G
-
Y
WVA
D
A
K
LG
Y
R
V
N
R
NL
D
FQLN
V
Y
NLFD
-
-
-
------
-
-
-
-
---
-
T
D
YVA
SI
N
KSG
Y
R
Y
H
PG
EP
RT
FL
L
TA
N
M
HF
fig|331111.12.peg.1164
Escherichia coli E24377A (10-760/760)
RQF
HSLT
FFAG
L
-
CI
G
IT
-
P
V
A
Q
A
LA
A
E
GQTNA
DDTLVV
E
A
-
S
T
P
SL
-
Y
AP
QQ
S
ADP
KFSRPVADTTRTM
TV
I
S
EQVI
KD
Q
GAT
NLT
D
AL
K
N
V
PGV
G
A
FFA
GE
N
GNST
T
G
D
-----
A
I
Y
M
RG
ADTS
N
S-
------
IYIDG
-
-
IR
D
I
G
SV
----
--S
RDT
FN
---------
T
E
Q
VEV
IK
GP
S
GT
D
YG
R
SA
P
T
G
S
IN
M
I
S
KQP
RN---
-
--
D
S
G
I
D
A
SA
S
IGSAWFR
R
GT
L
D
V
N
QV
I
-
GD
TTAV
RL
NV
MGE
--
KT
H
D
-
---
--
-
--
-
-----
---------
AGR
DK
V
K
N
E
-----
-
R
YGV
AP
--
S
IAFGL
G
TANRLY
L
N
Y
LHV
TQ
HNTP
D
GGIPTIGLPGYSAPS
AG
T
AA
LN
HS
G
K
V
D
T
HNF
Y
GT
--
-
---
D
SD
Y
D
D
S
T
T
D
T
ATMRF
EH
DINDNTTIRNT
TR
W
SR
VK
QD
YLMT
A
IM
G
-----
G
ASNITQPT
S
-------
D
V
N
S
W
T
W
S
RTA
NT
K
D
VSNKI
L
T
--
NQT
NLTS
TF
YT
GS
IG
HDV
S
T
G
V
E
FTR
E
T
Q
TNYGV
N
PVT
L
PAV
N
I
YHP
DSS
I
HP
G
GL
T
R
NG
------------------
A
N
A
N
GQ
TD
TFA
I
YA
FD
T
LQ
I
T
R
D
F
E
L
N
GG
I
R
L
D
-
-
-----
NYH
TEYDSATAC
G
G
S
G
RGAI
T
CPA
G
V
A
KG
SPVTTVDTAKSGNLVN
W
KA
G
ALY
H
LT
E
N
GN
V
YI
N
YA
VSQQ
P
P
G
G
N
NF
A
LA
Q
S
G
SGNSANRT
DFK
PQ
K
ANT
S
EIGT
KWQ
VL
D
K
R
L
L
LT
A
A
L
FR
T
D
IE
N
EV
E
-
-
-
-
--
-
QN
DD
GT
----
Y
S
Q
Y
GK
K
R
VEG
Y
E
I
S
VAGNIT
P
----
--A
W
QV
I
G
G
Y
---
T
Q
Q
K
A
T
IKNG
K
D
VAQDG
S
S
S
LP
YT
PE
H
AFT
L
WSQY
QA
TD
D
I
S
V
G
AGA
R
Y
I
G
S--
-
---
-
M
H
KG
SDGAV
G
TPAFTE
G
-
Y
WVA
D
A
K
LG
Y
R
V
N
R
NL
D
FQLN
V
Y
NLFD
-
-
-
------
-
-
-
-
---
-
T
D
YVA
SI
N
KSG
Y
R
Y
H
PG
EP
RT
FL
L
TA
N
M
HF
fig|331111.3.peg.3373
Escherichia coli E24377A (10-760/760)
RQF
HSLT
FFAG
L
-
CI
G
IT
-
P
V
A
Q
A
LA
A
E
GQTNA
DDTLVV
E
A
-
S
T
P
SL
-
Y
AP
QQ
S
ADP
KFSRPVADTTRTM
TV
I
S
EQVI
KD
Q
GAT
NLT
D
AL
K
N
V
PGV
G
A
FFA
GE
N
GNST
T
G
D
-----
A
I
Y
M
RG
ADTS
N
S-
------
IYIDG
-
-
IR
D
I
G
SV
----
--S
RDT
FN
---------
T
E
Q
VEV
IK
GP
S
GT
D
YG
R
SA
P
T
G
S
IN
M
I
S
KQP
RN---
-
--
D
S
G
I
D
A
SA
S
IGSAWFR
R
GT
L
D
V
N
QV
I
-
GD
TTAV
RL
NV
MGE
--
KT
H
D
-
---
--
-
--
-
-----
---------
AGR
DK
V
K
N
E
-----
-
R
YGV
AP
--
S
IAFGL
G
TANRLY
L
N
Y
LHV
TQ
HNTP
D
GGIPTIGLPGYSAPS
AG
T
AA
LN
HS
G
K
V
D
T
HNF
Y
GT
--
-
---
D
SD
Y
D
D
S
T
T
D
T
ATMRF
EH
DINDNTTIRNT
TR
W
SR
VK
QD
YLMT
A
IM
G
-----
G
ASNITQPT
S
-------
D
V
N
S
W
T
W
S
RTA
NT
K
D
VSNKI
L
T
--
NQT
NLTS
TF
YT
GS
IG
HDV
S
T
G
V
E
FTR
E
T
Q
TNYGV
N
PVT
L
PAV
N
I
YHP
DSS
I
HP
G
GL
T
R
NG
------------------
A
N
A
N
GQ
TD
TFA
I
YA
FD
T
LQ
I
T
R
D
F
E
L
N
GG
I
R
L
D
-
-
-----
NYH
TEYDSATAC
G
G
S
G
RGAI
T
CPA
G
V
A
KG
SPVTTVDTAKSGNLVN
W
KA
G
ALY
H
LT
E
N
GN
V
YI
N
YA
VSQQ
P
P
G
G
N
NF
A
LA
Q
S
G
SGNSANRT
DFK
PQ
K
ANT
S
EIGT
KWQ
VL
D
K
R
L
L
LT
A
A
L
FR
T
D
IE
N
EV
E
-
-
-
-
--
-
QN
DD
GT
----
Y
S
Q
Y
GK
K
R
VEG
Y
E
I
S
VAGNIT
P
----
--A
W
QV
I
G
G
Y
---
T
Q
Q
K
A
T
IKNG
K
D
VAQDG
S
S
S
LP
YT
PE
H
AFT
L
WSQY
QA
TD
D
I
S
V
G
AGA
R
Y
I
G
S--
-
---
-
M
H
KG
SDGAV
G
TPAFTE
G
-
Y
WVA
D
A
K
LG
Y
R
V
N
R
NL
D
FQLN
V
Y
NLFD
-
-
-
------
-
-
-
-
---
-
T
D
YVA
SI
N
KSG
Y
R
Y
H
PG
EP
RT
FL
L
TA
N
M
HF
fig|595495.4.peg.3218
Escherichia coli KO11 (10-760/760)
RQF
HSLT
FFAG
L
-
CI
G
IT
-
P
V
A
Q
A
LA
A
E
GQTNA
DDTLVV
E
A
-
S
T
P
SL
-
Y
AP
QQ
S
ADP
KFSRPVADTTRTM
TV
I
S
EQVI
KD
Q
GAT
NLT
D
AL
K
N
V
PGV
G
A
FFA
GE
N
GNST
T
G
D
-----
A
I
Y
M
RG
ADTS
N
S-
------
IYIDG
-
-
IR
D
I
G
SV
----
--S
RDT
FN
---------
T
E
Q
VEV
IK
GP
S
GT
D
YG
R
SA
P
T
G
S
IN
M
I
S
KQP
RN---
-
--
D
S
G
I
D
A
SA
S
IGSAWFR
R
GT
L
D
V
N
QV
I
-
GD
TTAV
RL
NV
MGE
--
KT
H
D
-
---
--
-
--
-
-----
---------
AGR
DK
V
K
N
E
-----
-
R
YGV
AP
--
S
IAFGL
G
TANRLY
L
N
Y
LHV
TQ
HNTP
D
GGIPTIGLPGYSAPS
AG
T
AA
LN
HS
G
K
V
D
T
HNF
Y
GT
--
-
---
D
SD
Y
D
D
S
T
T
D
T
ATMRF
EH
DINDNTTIRNT
TR
W
SR
VK
QD
YLMT
A
IM
G
-----
G
ASNITQPT
S
-------
D
V
N
S
W
T
W
S
RTA
NT
K
D
VSNKI
L
T
--
NQT
NLTS
TF
YT
GS
IG
HDV
S
T
G
V
E
FTR
E
T
Q
TNYGV
N
PVT
L
PAV
N
I
YHP
DSS
I
HP
G
GL
T
R
NG
------------------
A
N
A
N
GQ
TD
TFA
I
YA
FD
T
LQ
I
T
R
D
F
E
L
N
GG
I
R
L
D
-
-
-----
NYH
TEYDSATAC
G
G
S
G
RGAI
T
CPA
G
V
A
KG
SPVTTVDTAKSGNLVN
W
KA
G
ALY
H
LT
E
N
GN
V
YI
N
YA
VSQQ
P
P
G
G
N
NF
A
LA
Q
S
G
SGNSANRT
DFK
PQ
K
ANT
S
EIGT
KWQ
VL
D
K
R
L
L
LT
A
A
L
FR
T
D
IE
N
EV
E
-
-
-
-
--
-
QN
DD
GT
----
Y
S
Q
Y
GK
K
R
VEG
Y
E
I
S
VAGNIT
P
----
--A
W
QV
I
G
G
Y
---
T
Q
Q
K
A
T
IKNG
K
D
VAQDG
S
S
S
LP
YT
PE
H
AFT
L
WSQY
QA
TD
D
I
S
V
G
AGA
R
Y
I
G
S--
-
---
-
M
H
KG
SDGAV
G
TPAFTE
G
-
Y
WVA
D
A
K
LG
Y
R
V
N
R
NL
D
FQLN
V
Y
NLFD
-
-
-
------
-
-
-
-
---
-
T
D
YVA
SI
N
KSG
Y
R
Y
H
PG
EP
RT
FL
L
TA
N
M
HF
fig|679207.4.peg.1463
Escherichia coli MS 107-1 (10-760/760)
RQF
HSLT
FFAG
L
-
CI
G
IT
-
P
V
A
Q
A
LA
A
E
GQTNA
DDTLVV
E
A
-
S
T
P
SL
-
Y
AP
QQ
S
ADP
KFSRPVADTTRTM
TV
I
S
EQVI
KD
Q
GAT
NLT
D
AL
K
N
V
PGV
G
A
FFA
GE
N
GNST
T
G
D
-----
A
I
Y
M
RG
ADTS
N
S-
------
IYIDG
-
-
IR
D
I
G
SV
----
--S
RDT
FN
---------
T
E
Q
VEV
IK
GP
S
GT
D
YG
R
SA
P
T
G
S
IN
M
I
S
KQP
RN---
-
--
D
S
G
I
D
A
SA
S
IGSAWFR
R
GT
L
D
V
N
QV
I
-
GD
TTAV
RL
NV
MGE
--
KT
H
D
-
---
--
-
--
-
-----
---------
AGR
DK
V
K
N
E
-----
-
R
YGV
AP
--
S
IAFGL
G
TANRLY
L
N
Y
LHV
TQ
HNTP
D
GGIPTIGLPGYSAPS
AG
T
AA
LN
HS
G
K
V
D
T
HNF
Y
GT
--
-
---
D
SD
Y
D
D
S
T
T
D
T
ATMRF
EH
DINDNTTIRNT
TR
W
SR
VK
QD
YLMT
A
IM
G
-----
G
ASNITQPT
S
-------
D
V
N
S
W
T
W
S
RTA
NT
K
D
VSNKI
L
T
--
NQT
NLTS
TF
YT
GS
IG
HDV
S
T
G
V
E
FTR
E
T
Q
TNYGV
N
PVT
L
PAV
N
I
YHP
DSS
I
HP
G
GL
T
R
NG
------------------
A
N
A
N
GQ
TD
TFA
I
YA
FD
T
LQ
I
T
R
D
F
E
L
N
GG
I
R
L
D
-
-
-----
NYH
TEYDSATAC
G
G
S
G
RGAI
T
CPA
G
V
A
KG
SPVTTVDTAKSGNLVN
W
KA
G
ALY
H
LT
E
N
GN
V
YI
N
YA
VSQQ
P
P
G
G
N
NF
A
LA
Q
S
G
SGNSANRT
DFK
PQ
K
ANT
S
EIGT
KWQ
VL
D
K
R
L
L
LT
A
A
L
FR
T
D
IE
N
EV
E
-
-
-
-
--
-
QN
DD
GT
----
Y
S
Q
Y
GK
K
R
VEG
Y
E
I
S
VAGNIT
P
----
--A
W
QV
I
G
G
Y
---
T
Q
Q
K
A
T
IKNG
K
D
VAQDG
S
S
S
LP
YT
PE
H
AFT
L
WSQY
QA
TD
D
I
S
V
G
AGA
R
Y
I
G
S--
-
---
-
M
H
KG
SDGAV
G
TPAFTE
G
-
Y
WVA
D
A
K
LG
Y
R
V
N
R
NL
D
FQLN
V
Y
NLFD
-
-
-
------
-
-
-
-
---
-
T
D
YVA
SI
N
KSG
Y
R
Y
H
PG
EP
RT
FL
L
TA
N
M
HF
fig|749545.3.peg.1000
Escherichia coli MS 182-1 (10-760/760)
RQF
HSLT
FFAG
L
-
CI
G
IT
-
P
V
A
Q
A
LA
A
E
GQTNA
DDTLVV
E
A
-
S
T
P
SL
-
Y
AP
QQ
S
ADP
KFSRPVADTTRTM
TV
I
S
EQVI
KD
Q
GAT
NLT
D
AL
K
N
V
PGV
G
A
FFA
GE
N
GNST
T
G
D
-----
A
I
Y
M
RG
ADTS
N
S-
------
IYIDG
-
-
IR
D
I
G
SV
----
--S
RDT
FN
---------
T
E
Q
VEV
IK
GP
S
GT
D
YG
R
SA
P
T
G
S
IN
M
I
S
KQP
RN---
-
--
D
S
G
I
D
A
SA
S
IGSAWFR
R
GT
L
D
V
N
QV
I
-
GD
TTAV
RL
NV
MGE
--
KT
H
D
-
---
--
-
--
-
-----
---------
AGR
DK
V
K
N
E
-----
-
R
YGV
AP
--
S
IAFGL
G
TANRLY
L
N
Y
LHV
TQ
HNTP
D
GGIPTIGLPGYSAPS
AG
T
AA
LN
HS
G
K
V
D
T
HNF
Y
GT
--
-
---
D
SD
Y
D
D
S
T
T
D
T
ATMRF
EH
DINDNTTIRNT
TR
W
SR
VK
QD
YLMT
A
IM
G
-----
G
ASNITQPT
S
-------
D
V
N
S
W
T
W
S
RTA
NT
K
D
VSNKI
L
T
--
NQT
NLTS
TF
YT
GS
IG
HDV
S
T
G
V
E
FTR
E
T
Q
TNYGV
N
PVT
L
PAV
N
I
YHP
DSS
I
HP
G
GL
T
R
NG
------------------
A
N
A
N
GQ
TD
TFA
I
YA
FD
T
LQ
I
T
R
D
F
E
L
N
GG
I
R
L
D
-
-
-----
NYH
TEYDSATAC
G
G
S
G
RGAI
T
CPA
G
V
A
KG
SPVTTVDTAKSGNLVN
W
KA
G
ALY
H
LT
E
N
GN
V
YI
N
YA
VSQQ
P
P
G
G
N
NF
A
LA
Q
S
G
SGNSANRT
DFK
PQ
K
ANT
S
EIGT
KWQ
VL
D
K
R
L
L
LT
A
A
L
FR
T
D
IE
N
EV
E
-
-
-
-
--
-
QN
DD
GT
----
Y
S
Q
Y
GK
K
R
VEG
Y
E
I
S
VAGNIT
P
----
--A
W
QV
I
G
G
Y
---
T
Q
Q
K
A
T
IKNG
K
D
VAQDG
S
S
S
LP
YT
PE
H
AFT
L
WSQY
QA
TD
D
I
S
V
G
AGA
R
Y
I
G
S--
-
---
-
M
H
KG
SDGAV
G
TPAFTE
G
-
Y
WVA
D
A
K
LG
Y
R
V
N
R
NL
D
FQLN
V
Y
NLFD
-
-
-
------
-
-
-
-
---
-
T
D
YVA
SI
N
KSG
Y
R
Y
H
PG
EP
RT
FL
L
TA
N
M
HF
fig|749532.3.peg.2677
Escherichia coli MS 78-1 (10-760/760)
RQF
HSLT
FFAG
L
-
CI
G
IT
-
P
V
A
Q
A
LA
A
E
GQTNA
DDTLVV
E
A
-
S
T
P
SL
-
Y
AP
QQ
S
ADP
KFSRPVADTTRTM
TV
I
S
EQVI
KD
Q
GAT
NLT
D
AL
K
N
V
PGV
G
A
FFA
GE
N
GNST
T
G
D
-----
A
I
Y
M
RG
ADTS
N
S-
------
IYIDG
-
-
IR
D
I
G
SV
----
--S
RDT
FN
---------
T
E
Q
VEV
IK
GP
S
GT
D
YG
R
SA
P
T
G
S
IN
M
I
S
KQP
RN---
-
--
D
S
G
I
D
A
SA
S
IGSAWFR
R
GT
L
D
V
N
QV
I
-
GD
TTAV
RL
NV
MGE
--
KT
H
D
-
---
--
-
--
-
-----
---------
AGR
DK
V
K
N
E
-----
-
R
YGV
AP
--
S
IAFGL
G
TANRLY
L
N
Y
LHV
TQ
HNTP
D
GGIPTIGLPGYSAPS
AG
T
AA
LN
HS
G
K
V
D
T
HNF
Y
GT
--
-
---
D
SD
Y
D
D
S
T
T
D
T
ATMRF
EH
DINDNTTIRNT
TR
W
SR
VK
QD
YLMT
A
IM
G
-----
G
ASNITQPT
S
-------
D
V
N
S
W
T
W
S
RTA
NT
K
D
VSNKI
L
T
--
NQT
NLTS
TF
YT
GS
IG
HDV
S
T
G
V
E
FTR
E
T
Q
TNYGV
N
PVT
L
PAV
N
I
YHP
DSS
I
HP
G
GL
T
R
NG
------------------
A
N
A
N
GQ
TD
TFA
I
YA
FD
T
LQ
I
T
R
D
F
E
L
N
GG
I
R
L
D
-
-
-----
NYH
TEYDSATAC
G
G
S
G
RGAI
T
CPA
G
V
A
KG
SPVTTVDTAKSGNLVN
W
KA
G
ALY
H
LT
E
N
GN
V
YI
N
YA
VSQQ
P
P
G
G
N
NF
A
LA
Q
S
G
SGNSANRT
DFK
PQ
K
ANT
S
EIGT
KWQ
VL
D
K
R
L
L
LT
A
A
L
FR
T
D
IE
N
EV
E
-
-
-
-
--
-
QN
DD
GT
----
Y
S
Q
Y
GK
K
R
VEG
Y
E
I
S
VAGNIT
P
----
--A
W
QV
I
G
G
Y
---
T
Q
Q
K
A
T
IKNG
K
D
VAQDG
S
S
S
LP
YT
PE
H
AFT
L
WSQY
QA
TD
D
I
S
V
G
AGA
R
Y
I
G
S--
-
---
-
M
H
KG
SDGAV
G
TPAFTE
G
-
Y
WVA
D
A
K
LG
Y
R
V
N
R
NL
D
FQLN
V
Y
NLFD
-
-
-
------
-
-
-
-
---
-
T
D
YVA
SI
N
KSG
Y
R
Y
H
PG
EP
RT
FL
L
TA
N
M
HF
fig|409438.11.peg.987
Escherichia coli SE11 (10-760/760)
RQF
HSLT
FFAG
L
-
CI
G
IT
-
P
V
A
Q
A
LA
A
E
GQTNA
DDTLVV
E
A
-
S
T
P
SL
-
Y
AP
QQ
S
ADP
KFSRPVADTTRTM
TV
I
S
EQVI
KD
Q
GAT
NLT
D
AL
K
N
V
PGV
G
A
FFA
GE
N
GNST
T
G
D
-----
A
I
Y
M
RG
ADTS
N
S-
------
IYIDG
-
-
IR
D
I
G
SV
----
--S
RDT
FN
---------
T
E
Q
VEV
IK
GP
S
GT
D
YG
R
SA
P
T
G
S
IN
M
I
S
KQP
RN---
-
--
D
S
G
I
D
A
SA
S
IGSAWFR
R
GT
L
D
V
N
QV
I
-
GD
TTAV
RL
NV
MGE
--
KT
H
D
-
---
--
-
--
-
-----
---------
AGR
DK
V
K
N
E
-----
-
R
YGV
AP
--
S
IAFGL
G
TANRLY
L
N
Y
LHV
TQ
HNTP
D
GGIPTIGLPGYSAPS
AG
T
AA
LN
HS
G
K
V
D
T
HNF
Y
GT
--
-
---
D
SD
Y
D
D
S
T
T
D
T
ATMRF
EH
DINDNTTIRNT
TR
W
SR
VK
QD
YLMT
A
IM
G
-----
G
ASNITQPT
S
-------
D
V
N
S
W
T
W
S
RTA
NT
K
D
VSNKI
L
T
--
NQT
NLTS
TF
YT
GS
IG
HDV
S
T
G
V
E
FTR
E
T
Q
TNYGV
N
PVT
L
PAV
N
I
YHP
DSS
I
HP
G
GL
T
R
NG
------------------
A
N
A
N
GQ
TD
TFA
I
YA
FD
T
LQ
I
T
R
D
F
E
L
N
GG
I
R
L
D
-
-
-----
NYH
TEYDSATAC
G
G
S
G
RGAI
T
CPA
G
V
A
KG
SPVTTVDTAKSGNLVN
W
KA
G
ALY
H
LT
E
N
GN
V
YI
N
YA
VSQQ
P
P
G
G
N
NF
A
LA
Q
S
G
SGNSANRT
DFK
PQ
K
ANT
S
EIGT
KWQ
VL
D
K
R
L
L
LT
A
A
L
FR
T
D
IE
N
EV
E
-
-
-
-
--
-
QN
DD
GT
----
Y
S
Q
Y
GK
K
R
VEG
Y
E
I
S
VAGNIT
P
----
--A
W
QV
I
G
G
Y
---
T
Q
Q
K
A
T
IKNG
K
D
VAQDG
S
S
S
LP
YT
PE
H
AFT
L
WSQY
QA
TD
D
I
S
V
G
AGA
R
Y
I
G
S--
-
---
-
M
H
KG
SDGAV
G
TPAFTE
G
-
Y
WVA
D
A
K
LG
Y
R
V
N
R
NL
D
FQLN
V
Y
NLFD
-
-
-
------
-
-
-
-
---
-
T
D
YVA
SI
N
KSG
Y
R
Y
H
PG
EP
RT
FL
L
TA
N
M
HF
fig|566546.3.peg.3760
Escherichia coli W (10-760/760)
RQF
HSLT
FFAG
L
-
CI
G
IT
-
P
V
A
Q
A
LA
A
E
GQTNA
DDTLVV
E
A
-
S
T
P
SL
-
Y
AP
QQ
S
ADP
KFSRPVADTTRTM
TV
I
S
EQVI
KD
Q
GAT
NLT
D
AL
K
N
V
PGV
G
A
FFA
GE
N
GNST
T
G
D
-----
A
I
Y
M
RG
ADTS
N
S-
------
IYIDG
-
-
IR
D
I
G
SV
----
--S
RDT
FN
---------
T
E
Q
VEV
IK
GP
S
GT
D
YG
R
SA
P
T
G
S
IN
M
I
S
KQP
RN---
-
--
D
S
G
I
D
A
SA
S
IGSAWFR
R
GT
L
D
V
N
QV
I
-
GD
TTAV
RL
NV
MGE
--
KT
H
D
-
---
--
-
--
-
-----
---------
AGR
DK
V
K
N
E
-----
-
R
YGV
AP
--
S
IAFGL
G
TANRLY
L
N
Y
LHV
TQ
HNTP
D
GGIPTIGLPGYSAPS
AG
T
AA
LN
HS
G
K
V
D
T
HNF
Y
GT
--
-
---
D
SD
Y
D
D
S
T
T
D
T
ATMRF
EH
DINDNTTIRNT
TR
W
SR
VK
QD
YLMT
A
IM
G
-----
G
ASNITQPT
S
-------
D
V
N
S
W
T
W
S
RTA
NT
K
D
VSNKI
L
T
--
NQT
NLTS
TF
YT
GS
IG
HDV
S
T
G
V
E
FTR
E
T
Q
TNYGV
N
PVT
L
PAV
N
I
YHP
DSS
I
HP
G
GL
T
R
NG
------------------
A
N
A
N
GQ
TD
TFA
I
YA
FD
T
LQ
I
T
R
D
F
E
L
N
GG
I
R
L
D
-
-
-----
NYH
TEYDSATAC
G
G
S
G
RGAI
T
CPA
G
V
A
KG
SPVTTVDTAKSGNLVN
W
KA
G
ALY
H
LT
E
N
GN
V
YI
N
YA
VSQQ
P
P
G
G
N
NF
A
LA
Q
S
G
SGNSANRT
DFK
PQ
K
ANT
S
EIGT
KWQ
VL
D
K
R
L
L
LT
A
A
L
FR
T
D
IE
N
EV
E
-
-
-
-
--
-
QN
DD
GT
----
Y
S
Q
Y
GK
K
R
VEG
Y
E
I
S
VAGNIT
P
----
--A
W
QV
I
G
G
Y
---
T
Q
Q
K
A
T
IKNG
K
D
VAQDG
S
S
S
LP
YT
PE
H
AFT
L
WSQY
QA
TD
D
I
S
V
G
AGA
R
Y
I
G
S--
-
---
-
M
H
KG
SDGAV
G
TPAFTE
G
-
Y
WVA
D
A
K
LG
Y
R
V
N
R
NL
D
FQLN
V
Y
NLFD
-
-
-
------
-
-
-
-
---
-
T
D
YVA
SI
N
KSG
Y
R
Y
H
PG
EP
RT
FL
L
TA
N
M
HF
fig|566546.4.peg.854
Escherichia coli W (10-760/760)
RQF
HSLT
FFAG
L
-
CI
G
IT
-
P
V
A
Q
A
LA
A
E
GQTNA
DDTLVV
E
A
-
S
T
P
SL
-
Y
AP
QQ
S
ADP
KFSRPVADTTRTM
TV
I
S
EQVI
KD
Q
GAT
NLT
D
AL
K
N
V
PGV
G
A
FFA
GE
N
GNST
T
G
D
-----
A
I
Y
M
RG
ADTS
N
S-
------
IYIDG
-
-
IR
D
I
G
SV
----
--S
RDT
FN
---------
T
E
Q
VEV
IK
GP
S
GT
D
YG
R
SA
P
T
G
S
IN
M
I
S
KQP
RN---
-
--
D
S
G
I
D
A
SA
S
IGSAWFR
R
GT
L
D
V
N
QV
I
-
GD
TTAV
RL
NV
MGE
--
KT
H
D
-
---
--
-
--
-
-----
---------
AGR
DK
V
K
N
E
-----
-
R
YGV
AP
--
S
IAFGL
G
TANRLY
L
N
Y
LHV
TQ
HNTP
D
GGIPTIGLPGYSAPS
AG
T
AA
LN
HS
G
K
V
D
T
HNF
Y
GT
--
-
---
D
SD
Y
D
D
S
T
T
D
T
ATMRF
EH
DINDNTTIRNT
TR
W
SR
VK
QD
YLMT
A
IM
G
-----
G
ASNITQPT
S
-------
D
V
N
S
W
T
W
S
RTA
NT
K
D
VSNKI
L
T
--
NQT
NLTS
TF
YT
GS
IG
HDV
S
T
G
V
E
FTR
E
T
Q
TNYGV
N
PVT
L
PAV
N
I
YHP
DSS
I
HP
G
GL
T
R
NG
------------------
A
N
A
N
GQ
TD
TFA
I
YA
FD
T
LQ
I
T
R
D
F
E
L
N
GG
I
R
L
D
-
-
-----
NYH
TEYDSATAC
G
G
S
G
RGAI
T
CPA
G
V
A
KG
SPVTTVDTAKSGNLVN
W
KA
G
ALY
H
LT
E
N
GN
V
YI
N
YA
VSQQ
P
P
G
G
N
NF
A
LA
Q
S
G
SGNSANRT
DFK
PQ
K
ANT
S
EIGT
KWQ
VL
D
K
R
L
L
LT
A
A
L
FR
T
D
IE
N
EV
E
-
-
-
-
--
-
QN
DD
GT
----
Y
S
Q
Y
GK
K
R
VEG
Y
E
I
S
VAGNIT
P
----
--A
W
QV
I
G
G
Y
---
T
Q
Q
K
A
T
IKNG
K
D
VAQDG
S
S
S
LP
YT
PE
H
AFT
L
WSQY
QA
TD
D
I
S
V
G
AGA
R
Y
I
G
S--
-
---
-
M
H
KG
SDGAV
G
TPAFTE
G
-
Y
WVA
D
A
K
LG
Y
R
V
N
R
NL
D
FQLN
V
Y
NLFD
-
-
-
------
-
-
-
-
---
-
T
D
YVA
SI
N
KSG
Y
R
Y
H
PG
EP
RT
FL
L
TA
N
M
HF
fig|362663.8.peg.826
Escherichia coli 536 (10-760/760)
RQF
HSLT
FFAG
L
-
CI
G
IT
-
P
V
A
Q
A
LA
A
E
GQANA
DDTLVV
E
A
-
S
T
P
SL
-
Y
AP
QQ
S
ADP
KFSRPVADTTRTM
TV
I
S
EQVI
KD
Q
GAT
NLT
D
AL
K
N
V
PGV
G
A
FFA
GE
N
GNST
T
G
D
-----
A
I
Y
M
RG
ADTS
N
S-
------
IYIDG
-
-
IR
D
I
G
SV
----
--S
RDT
FN
---------
T
E
Q
VEV
IK
GP
S
GT
D
YG
R
SA
P
T
G
S
IN
M
I
S
KQP
RN---
-
--
D
S
G
I
D
A
SA
S
IGSAWFR
R
GT
L
D
V
N
QV
I
-
GD
TTAV
RL
NV
MGE
--
KT
H
D
-
---
--
-
--
-
-----
---------
AGR
DK
V
K
N
E
-----
-
R
YGV
AP
--
S
VAFGL
G
TANRLY
L
N
Y
LHV
TQ
HNTP
D
GGIPTIGLPGYSAPS
AG
T
AA
LN
HS
G
K
V
D
T
HNF
Y
GT
--
-
---
D
SD
Y
D
D
S
T
T
D
T
ATMRF
EH
DINDNTTIRNT
TR
W
SR
VK
QD
YLMT
A
IM
G
-----
G
ASNITQPT
S
-------
D
V
N
S
W
T
W
S
RTA
NT
K
D
VSNKI
L
T
--
NQT
NLTS
TF
YT
G
A
IG
HDV
S
T
G
V
E
FTR
E
T
Q
TNYGV
N
PVT
L
PAV
N
I
YHP
DSS
I
HP
G
GL
T
R
NG
------------------
A
N
A
N
GQ
TD
TFA
I
YA
FD
T
LQ
I
T
R
D
F
E
L
N
GG
I
R
L
D
-
-
-----
NYH
TEYDSATAY
G
G
S
G
RGAI
T
CPA
G
V
A
KG
SPVTTVDTAKSGNLVN
W
KA
G
ALY
H
LT
E
N
GN
V
YI
N
YA
VSQQ
P
P
G
G
N
NF
A
LA
Q
S
G
SGNSANRT
DFK
PQ
K
ANT
S
EIGT
KWQ
VL
D
K
R
L
L
LT
A
A
L
FR
T
D
IE
N
EV
E
-
-
-
-
--
-
QN
DD
GT
----
Y
S
Q
Y
GK
K
R
VEG
Y
E
I
S
VAGNIT
P
----
--A
W
QM
I
G
G
Y
---
T
Q
Q
K
A
T
IKNG
K
D
VAQDG
S
S
S
LP
YT
PE
H
AFT
L
WSQY
QA
TD
D
I
S
V
G
AGA
R
Y
I
G
S--
-
---
-
M
H
KG
SDGAV
G
TPAFTE
D
-
Y
WVA
D
A
K
LG
Y
R
V
N
R
NL
D
FQLN
V
Y
NLFD
-
-
-
------
-
-
-
-
---
-
T
D
YVA
SI
N
KSG
Y
R
Y
H
PG
EP
RT
FL
L
TA
N
M
HF
fig|362663.9.peg.826
Escherichia coli 536 (10-760/760)
RQF
HSLT
FFAG
L
-
CI
G
IT
-
P
V
A
Q
A
LA
A
E
GQANA
DDTLVV
E
A
-
S
T
P
SL
-
Y
AP
QQ
S
ADP
KFSRPVADTTRTM
TV
I
S
EQVI
KD
Q
GAT
NLT
D
AL
K
N
V
PGV
G
A
FFA
GE
N
GNST
T
G
D
-----
A
I
Y
M
RG
ADTS
N
S-
------
IYIDG
-
-
IR
D
I
G
SV
----
--S
RDT
FN
---------
T
E
Q
VEV
IK
GP
S
GT
D
YG
R
SA
P
T
G
S
IN
M
I
S
KQP
RN---
-
--
D
S
G
I
D
A
SA
S
IGSAWFR
R
GT
L
D
V
N
QV
I
-
GD
TTAV
RL
NV
MGE
--
KT
H
D
-
---
--
-
--
-
-----
---------
AGR
DK
V
K
N
E
-----
-
R
YGV
AP
--
S
VAFGL
G
TANRLY
L
N
Y
LHV
TQ
HNTP
D
GGIPTIGLPGYSAPS
AG
T
AA
LN
HS
G
K
V
D
T
HNF
Y
GT
--
-
---
D
SD
Y
D
D
S
T
T
D
T
ATMRF
EH
DINDNTTIRNT
TR
W
SR
VK
QD
YLMT
A
IM
G
-----
G
ASNITQPT
S
-------
D
V
N
S
W
T
W
S
RTA
NT
K
D
VSNKI
L
T
--
NQT
NLTS
TF
YT
G
A
IG
HDV
S
T
G
V
E
FTR
E
T
Q
TNYGV
N
PVT
L
PAV
N
I
YHP
DSS
I
HP
G
GL
T
R
NG
------------------
A
N
A
N
GQ
TD
TFA
I
YA
FD
T
LQ
I
T
R
D
F
E
L
N
GG
I
R
L
D
-
-
-----
NYH
TEYDSATAY
G
G
S
G
RGAI
T
CPA
G
V
A
KG
SPVTTVDTAKSGNLVN
W
KA
G
ALY
H
LT
E
N
GN
V
YI
N
YA
VSQQ
P
P
G
G
N
NF
A
LA
Q
S
G
SGNSANRT
DFK
PQ
K
ANT
S
EIGT
KWQ
VL
D
K
R
L
L
LT
A
A
L
FR
T
D
IE
N
EV
E
-
-
-
-
--
-
QN
DD
GT
----
Y
S
Q
Y
GK
K
R
VEG
Y
E
I
S
VAGNIT
P
----
--A
W
QM
I
G
G
Y
---
T
Q
Q
K
A
T
IKNG
K
D
VAQDG
S
S
S
LP
YT
PE
H
AFT
L
WSQY
QA
TD
D
I
S
V
G
AGA
R
Y
I
G
S--
-
---
-
M
H
KG
SDGAV
G
TPAFTE
D
-
Y
WVA
D
A
K
LG
Y
R
V
N
R
NL
D
FQLN
V
Y
NLFD
-
-
-
------
-
-
-
-
---
-
T
D
YVA
SI
N
KSG
Y
R
Y
H
PG
EP
RT
FL
L
TA
N
M
HF
fig|714962.3.peg.812
Escherichia coli IHE3034 (10-760/760)
RQF
HSLT
FFAG
L
-
CI
G
IT
-
P
V
A
Q
A
LA
A
E
GQANA
DDTLVV
E
A
-
S
T
P
SL
-
Y
AP
QQ
S
ADP
KFSRPVADTTRTM
TV
I
S
EQVI
KD
Q
GAT
NLT
D
AL
K
N
V
PGV
G
A
FFA
GE
N
GNST
T
G
D
-----
A
I
Y
M
RG
ADTS
N
S-
------
IYIDG
-
-
IR
D
I
G
SV
----
--S
RDT
FN
---------
T
E
Q
VEV
IK
GP
S
GT
D
YG
R
SA
P
T
G
S
IN
M
I
S
KQP
RN---
-
--
D
S
G
I
D
A
SA
S
IGSAWFR
R
GT
L
D
V
N
QV
I
-
GD
TTAV
RL
NV
MGE
--
KT
H
D
-
---
--
-
--
-
-----
---------
AGR
DK
V
K
N
E
-----
-
R
YGV
AP
--
S
VAFGL
G
TANRLY
L
N
Y
LHV
TQ
HNTP
D
GGIPTIGLPGYSAPS
AG
T
AA
LN
HS
G
K
V
D
T
HNF
Y
GT
--
-
---
D
SD
Y
D
D
S
T
T
D
T
ATMRF
EH
DINDNTTIRNT
TR
W
SR
VK
QD
YLMT
A
IM
G
-----
G
ASNITQPT
S
-------
D
V
N
S
W
T
W
S
RTA
NT
K
D
VSNKI
L
T
--
NQT
NLTS
TF
YT
G
A
IG
HDV
S
T
G
V
E
FTR
E
T
Q
TNYGV
N
PVT
L
PAV
N
I
YHP
DSS
I
HP
G
GL
T
R
NG
------------------
A
N
A
N
GQ
TD
TFA
I
YA
FD
T
LQ
I
T
R
D
F
E
L
N
GG
I
R
L
D
-
-
-----
NYH
TEYDSATAC
G
G
S
G
RGAI
T
CPA
G
V
A
KG
SPVTTVDTAKSGNLVN
W
KA
G
ALY
H
LT
E
N
GN
I
YI
N
YA
VSQQ
P
P
G
G
N
NF
A
LA
Q
S
G
SGNSANRT
DFK
PQ
K
ANT
S
EIGT
KWQ
VL
D
K
R
L
L
LT
A
A
L
FR
T
D
IE
N
EV
E
-
-
-
-
--
-
QN
DD
GT
----
Y
S
Q
Y
GK
K
R
VEG
Y
E
I
S
VAGNIT
P
----
--A
W
QM
I
G
G
Y
---
T
Q
Q
K
A
T
IKNG
K
D
VAQDG
S
S
S
LP
YT
PE
H
AFT
L
WSQY
QA
TD
D
I
S
V
G
AGA
R
Y
I
G
S--
-
---
-
M
H
KG
SDGAV
G
TPAFTE
G
-
Y
WVA
D
A
K
LG
Y
R
V
N
R
NL
D
FQLN
V
Y
NLFD
-
-
-
------
-
-
-
-
---
-
T
D
YVA
SI
N
KSG
Y
R
Y
H
PG
EP
RT
FL
L
TA
N
M
HF
fig|869729.3.peg.2908
Escherichia coli UM146 (10-760/760)
RQF
HSLT
FFAG
L
-
CI
G
IT
-
P
V
A
Q
A
LA
A
E
GQANA
DDTLVV
E
A
-
S
T
P
SL
-
Y
AP
QQ
S
ADP
KFSRPVADTTRTM
TV
I
S
EQVI
KD
Q
GAT
NLT
D
AL
K
N
V
PGV
G
A
FFA
GE
N
GNST
T
G
D
-----
A
I
Y
M
RG
ADTS
N
S-
------
IYIDG
-
-
IR
D
I
G
SV
----
--S
RDT
FN
---------
T
E
Q
VEV
IK
GP
S
GT
D
YG
R
SA
P
T
G
S
IN
M
I
S
KQP
RN---
-
--
D
S
G
I
D
A
SA
S
IGSAWFR
R
GT
L
D
V
N
QV
I
-
GD
TTAV
RL
NV
MGE
--
KT
H
D
-
---
--
-
--
-
-----
---------
AGR
DK
V
K
N
E
-----
-
R
YGV
AP
--
S
VAFGL
G
TANRLY
L
N
Y
LHV
TQ
HNTP
D
GGIPTIGLPGYSAPS
AG
T
AA
LN
HS
G
K
V
D
T
HNF
Y
GT
--
-
---
D
SD
Y
D
D
S
T
T
D
T
ATMRF
EH
DINDNTTIRNT
TR
W
SR
VK
QD
YLMT
A
IM
G
-----
G
ASNITQPT
S
-------
D
V
N
S
W
T
W
S
RTA
NT
K
D
VSNKI
L
T
--
NQT
NLTS
TF
YT
G
A
IG
HDV
S
T
G
V
E
FTR
E
T
Q
TNYGV
N
PVT
L
PAV
N
I
YHP
DSS
I
HP
G
GL
T
R
NG
------------------
A
N
A
N
GQ
TD
TFA
I
YA
FD
T
LQ
I
T
R
D
F
E
L
N
GG
I
R
L
D
-
-
-----
NYH
TEYDSATAC
G
G
S
G
RGAI
T
CPA
G
V
A
KG
SPVTTVDTAKSGNLVN
W
KA
G
ALY
H
LT
E
N
GN
I
YI
N
YA
VSQQ
P
P
G
G
N
NF
A
LA
Q
S
G
SGNSANRT
DFK
PQ
K
ANT
S
EIGT
KWQ
VL
D
K
R
L
L
LT
A
A
L
FR
T
D
IE
N
EV
E
-
-
-
-
--
-
QN
DD
GT
----
Y
S
Q
Y
GK
K
R
VEG
Y
E
I
S
VAGNIT
P
----
--A
W
QM
I
G
G
Y
---
T
Q
Q
K
A
T
IKNG
K
D
VAQDG
S
S
S
LP
YT
PE
H
AFT
L
WSQY
QA
TD
D
I
S
V
G
AGA
R
Y
I
G
S--
-
---
-
M
H
KG
SDGAV
G
TPAFTE
G
-
Y
WVA
D
A
K
LG
Y
R
V
N
R
NL
D
FQLN
V
Y
NLFD
-
-
-
------
-
-
-
-
---
-
T
D
YVA
SI
N
KSG
Y
R
Y
H
PG
EP
RT
FL
L
TA
N
M
HF
fig|364106.7.peg.893
Escherichia coli UTI89 (10-760/760)
RQF
HSLT
FFAG
L
-
CI
G
IT
-
P
V
A
Q
A
LA
A
E
GQANA
DDTLVV
E
A
-
S
T
P
SL
-
Y
AP
QQ
S
ADP
KFSRPVADTTRTM
TV
I
S
EQVI
KD
Q
GAT
NLT
D
AL
K
N
V
PGV
G
A
FFA
GE
N
GNST
T
G
D
-----
A
I
Y
M
RG
ADTS
N
S-
------
IYIDG
-
-
IR
D
I
G
SV
----
--S
RDT
FN
---------
T
E
Q
VEV
IK
GP
S
GT
D
YG
R
SA
P
T
G
S
IN
M
I
S
KQP
RN---
-
--
D
S
G
I
D
A
SA
S
IGSAWFR
R
GT
L
D
V
N
QV
I
-
GD
TTAV
RL
NV
MGE
--
KT
H
D
-
---
--
-
--
-
-----
---------
AGR
DK
V
K
N
E
-----
-
R
YGV
AP
--
S
VAFGL
G
TANRLY
L
N
Y
LHV
TQ
HNTP
D
GGIPTIGLPGYSAPS
AG
T
AA
LN
HS
G
K
V
D
T
HNF
Y
GT
--
-
---
D
SD
Y
D
D
S
T
T
D
T
ATMRF
EH
DINDNTTIRNT
TR
W
SR
VK
QD
YLMT
A
IM
G
-----
G
ASNITQPT
S
-------
D
V
N
S
W
T
W
S
RTA
NT
K
D
VSNKI
L
T
--
NQT
NLTS
TF
YT
G
A
IG
HDV
S
T
G
V
E
FTR
E
T
Q
TNYGV
N
PVT
L
PAV
N
I
YHP
DSS
I
HP
G
GL
T
R
NG
------------------
A
N
A
N
GQ
TD
TFA
I
YA
FD
T
LQ
I
T
R
D
F
E
L
N
GG
I
R
L
D
-
-
-----
NYH
TEYDSATAC
G
G
S
G
RGAI
T
CPA
G
V
A
KG
SPVTTVDTAKSGNLVN
W
KA
G
ALY
H
LT
E
N
GN
I
YI
N
YA
VSQQ
P
P
G
G
N
NF
A
LA
Q
S
G
SGNSANRT
DFK
PQ
K
ANT
S
EIGT
KWQ
VL
D
K
R
L
L
LT
A
A
L
FR
T
D
IE
N
EV
E
-
-
-
-
--
-
QN
DD
GT
----
Y
S
Q
Y
GK
K
R
VEG
Y
E
I
S
VAGNIT
P
----
--A
W
QM
I
G
G
Y
---
T
Q
Q
K
A
T
IKNG
K
D
VAQDG
S
S
S
LP
YT
PE
H
AFT
L
WSQY
QA
TD
D
I
S
V
G
AGA
R
Y
I
G
S--
-
---
-
M
H
KG
SDGAV
G
TPAFTE
G
-
Y
WVA
D
A
K
LG
Y
R
V
N
R
NL
D
FQLN
V
Y
NLFD
-
-
-
------
-
-
-
-
---
-
T
D
YVA
SI
N
KSG
Y
R
Y
H
PG
EP
RT
FL
L
TA
N
M
HF
fig|364106.8.peg.892
Escherichia coli UTI89 (10-760/760)
RQF
HSLT
FFAG
L
-
CI
G
IT
-
P
V
A
Q
A
LA
A
E
GQANA
DDTLVV
E
A
-
S
T
P
SL
-
Y
AP
QQ
S
ADP
KFSRPVADTTRTM
TV
I
S
EQVI
KD
Q
GAT
NLT
D
AL
K
N
V
PGV
G
A
FFA
GE
N
GNST
T
G
D
-----
A
I
Y
M
RG
ADTS
N
S-
------
IYIDG
-
-
IR
D
I
G
SV
----
--S
RDT
FN
---------
T
E
Q
VEV
IK
GP
S
GT
D
YG
R
SA
P
T
G
S
IN
M
I
S
KQP
RN---
-
--
D
S
G
I
D
A
SA
S
IGSAWFR
R
GT
L
D
V
N
QV
I
-
GD
TTAV
RL
NV
MGE
--
KT
H
D
-
---
--
-
--
-
-----
---------
AGR
DK
V
K
N
E
-----
-
R
YGV
AP
--
S
VAFGL
G
TANRLY
L
N
Y
LHV
TQ
HNTP
D
GGIPTIGLPGYSAPS
AG
T
AA
LN
HS
G
K
V
D
T
HNF
Y
GT
--
-
---
D
SD
Y
D
D
S
T
T
D
T
ATMRF
EH
DINDNTTIRNT
TR
W
SR
VK
QD
YLMT
A
IM
G
-----
G
ASNITQPT
S
-------
D
V
N
S
W
T
W
S
RTA
NT
K
D
VSNKI
L
T
--
NQT
NLTS
TF
YT
G
A
IG
HDV
S
T
G
V
E
FTR
E
T
Q
TNYGV
N
PVT
L
PAV
N
I
YHP
DSS
I
HP
G
GL
T
R
NG
------------------
A
N
A
N
GQ
TD
TFA
I
YA
FD
T
LQ
I
T
R
D
F
E
L
N
GG
I
R
L
D
-
-
-----
NYH
TEYDSATAC
G
G
S
G
RGAI
T
CPA
G
V
A
KG
SPVTTVDTAKSGNLVN
W
KA
G
ALY
H
LT
E
N
GN
I
YI
N
YA
VSQQ
P
P
G
G
N
NF
A
LA
Q
S
G
SGNSANRT
DFK
PQ
K
ANT
S
EIGT
KWQ
VL
D
K
R
L
L
LT
A
A
L
FR
T
D
IE
N
EV
E
-
-
-
-
--
-
QN
DD
GT
----
Y
S
Q
Y
GK
K
R
VEG
Y
E
I
S
VAGNIT
P
----
--A
W
QM
I
G
G
Y
---
T
Q
Q
K
A
T
IKNG
K
D
VAQDG
S
S
S
LP
YT
PE
H
AFT
L
WSQY
QA
TD
D
I
S
V
G
AGA
R
Y
I
G
S--
-
---
-
M
H
KG
SDGAV
G
TPAFTE
G
-
Y
WVA
D
A
K
LG
Y
R
V
N
R
NL
D
FQLN
V
Y
NLFD
-
-
-
------
-
-
-
-
---
-
T
D
YVA
SI
N
KSG
Y
R
Y
H
PG
EP
RT
FL
L
TA
N
M
HF
fig|1040638.4.peg.4914
Escherichia coli O104:H4 str. LB226692 (10-760/760)
RQF
HSLT
FFAG
L
-
CI
G
IT
-
P
V
A
Q
A
LA
A
E
GQTNA
DDTLVV
E
A
-
S
T
P
SL
-
Y
AP
QQ
S
ADP
KFSRPVADTTRTM
TV
I
S
EQVI
KD
Q
GAT
NLT
D
AL
K
N
V
PGV
G
A
FFA
GE
N
GNST
T
G
D
-----
A
I
Y
M
RG
ADTS
N
S-
------
IYIDG
-
-
IR
D
I
G
SV
----
--S
RDT
FN
---------
T
E
Q
VEV
IK
GP
S
GT
D
YG
R
SA
P
T
G
S
IN
M
I
S
KQP
RN---
-
--
D
S
G
I
D
A
SA
S
IGSAWFR
R
GT
L
D
V
N
QV
I
-
GD
TTAV
RL
NV
MGE
--
KT
H
D
-
---
--
-
--
-
-----
---------
AGR
DK
V
K
N
E
-----
-
R
YGV
AP
--
S
IAFGL
G
TANRLY
L
N
Y
LHV
TQ
HNTP
D
GGIPTIGLPGYSAPS
AG
T
AA
LN
HS
G
K
V
D
T
HNF
Y
GT
--
-
---
D
SD
Y
D
D
S
T
T
D
T
ATMRF
EH
DINDNTTIRNT
TR
W
SR
VK
QD
YLMT
A
IM
G
-----
G
ASNITQPT
S
-------
D
V
N
S
W
T
W
S
RTA
NT
K
D
VSNKI
L
T
--
NQT
NLTS
TF
YT
GS
IG
HDV
S
T
G
V
E
FTR
E
T
Q
TNYGV
N
PVT
L
PAV
N
I
YHP
DSS
I
HP
G
GL
T
R
NG
------------------
A
N
A
N
GQ
TD
TFA
I
YA
FD
T
LQ
I
T
R
D
F
E
L
N
GG
I
R
L
D
-
-
-----
NYH
TEYDSATAC
G
G
S
G
RGAI
T
CPT
G
V
A
KG
SPVTTVDTAKSGNLVN
W
KA
G
ALY
H
LT
E
N
GN
V
YI
N
YA
VSQQ
P
P
G
G
N
NF
A
LA
Q
S
G
SGNSANRT
DFK
PQ
K
ANT
S
EIGT
KWQ
VL
D
K
R
L
L
LT
A
A
L
FR
T
D
IE
N
EV
E
-
-
-
-
--
-
QN
DD
GT
----
Y
S
Q
Y
GK
K
R
VEG
Y
E
I
S
VAGNIT
P
----
--A
W
QV
I
G
G
Y
---
T
Q
Q
K
A
T
IKNG
K
D
VAQDG
S
S
S
LP
YT
PE
H
AFT
L
WSQY
QA
TD
D
I
S
V
G
AGA
R
Y
I
G
S--
-
---
-
M
H
KG
SDGAV
G
TPAFTE
G
-
Y
WVA
D
A
K
LG
Y
R
V
N
R
NL
D
FQLN
V
Y
NLFD
-
-
-
------
-
-
-
-
---
-
T
D
YVA
SI
N
KSG
Y
R
Y
H
PG
EP
RT
FL
L
TA
N
M
HF
fig|585055.6.peg.859
Escherichia coli 55989 (10-760/760)
RQF
HSLT
FFAG
L
-
CI
G
IT
-
P
V
A
Q
A
LA
A
E
GQTNA
DDTLVV
E
A
-
S
T
P
SL
-
Y
AP
QQ
S
ADP
KFSRPVADTTRTM
TV
I
S
EQVI
KD
Q
GAT
NLT
D
AL
K
N
V
PGV
G
A
FFA
GE
N
GNST
T
G
D
-----
A
I
Y
M
RG
ADTS
N
S-
------
IYIDG
-
-
IR
D
I
G
SV
----
--S
RDT
FN
---------
T
E
Q
VEV
IK
GP
S
GT
D
YG
R
SA
P
T
G
S
IN
M
I
S
KQP
RN---
-
--
D
S
G
I
D
A
SA
S
IGSAWFR
R
GT
L
D
V
N
QV
I
-
GD
TTAV
RL
NV
MGE
--
KT
H
D
-
---
--
-
--
-
-----
---------
AGR
DK
V
K
N
E
-----
-
R
YGV
AP
--
S
IAFGL
G
TANRLY
L
N
Y
LHV
TQ
HNTP
D
GGIPTIGLPGYSAPS
AG
T
AA
LN
HS
G
K
V
D
T
HNF
Y
GT
--
-
---
D
SD
Y
D
D
S
T
T
D
T
ATMRF
EH
DINDNTTIRNT
TR
W
SR
VK
QD
YLMT
A
IM
G
-----
G
ASNITQPT
S
-------
D
V
N
S
W
T
W
S
RTA
NT
K
D
VSNKI
L
T
--
NQT
NLTS
TF
YT
GS
IG
HDV
S
T
G
V
E
FTR
E
T
Q
TNYGV
N
PVT
L
PAV
N
I
YHP
DSS
I
HP
G
GL
T
R
NG
------------------
A
N
A
N
GQ
TD
TFA
I
YA
FD
T
LQ
I
T
R
D
F
E
L
N
GG
I
R
L
D
-
-
-----
NYH
TEYDSATAC
G
G
S
G
RGAI
T
CPT
G
V
A
KG
SPVTTVDTAKSGNLVN
W
KA
G
ALY
H
LT
E
N
GN
V
YI
N
YA
VSQQ
P
P
G
G
N
NF
A
LA
Q
S
G
SGNSANRT
DFK
PQ
K
ANT
S
EIGT
KWQ
VL
D
K
R
L
L
LT
A
A
L
FR
T
D
IE
N
EV
E
-
-
-
-
--
-
QN
DD
GT
----
Y
S
Q
Y
GK
K
R
VEG
Y
E
I
S
VAGNIT
P
----
--A
W
QV
I
G
G
Y
---
T
Q
Q
K
A
T
IKNG
K
D
VAQDG
S
S
S
LP
YT
PE
H
AFT
L
WSQY
QA
TD
D
I
S
V
G
AGA
R
Y
I
G
S--
-
---
-
M
H
KG
SDGAV
G
TPAFTE
G
-
Y
WVA
D
A
K
LG
Y
R
V
N
R
NL
D
FQLN
V
Y
NLFD
-
-
-
------
-
-
-
-
---
-
T
D
YVA
SI
N
KSG
Y
R
Y
H
PG
EP
RT
FL
L
TA
N
M
HF
fig|585055.8.peg.863
Escherichia coli 55989 (10-760/760)
RQF
HSLT
FFAG
L
-
CI
G
IT
-
P
V
A
Q
A
LA
A
E
GQTNA
DDTLVV
E
A
-
S
T
P
SL
-
Y
AP
QQ
S
ADP
KFSRPVADTTRTM
TV
I
S
EQVI
KD
Q
GAT
NLT
D
AL
K
N
V
PGV
G
A
FFA
GE
N
GNST
T
G
D
-----
A
I
Y
M
RG
ADTS
N
S-
------
IYIDG
-
-
IR
D
I
G
SV
----
--S
RDT
FN
---------
T
E
Q
VEV
IK
GP
S
GT
D
YG
R
SA
P
T
G
S
IN
M
I
S
KQP
RN---
-
--
D
S
G
I
D
A
SA
S
IGSAWFR
R
GT
L
D
V
N
QV
I
-
GD
TTAV
RL
NV
MGE
--
KT
H
D
-
---
--
-
--
-
-----
---------
AGR
DK
V
K
N
E
-----
-
R
YGV
AP
--
S
IAFGL
G
TANRLY
L
N
Y
LHV
TQ
HNTP
D
GGIPTIGLPGYSAPS
AG
T
AA
LN
HS
G
K
V
D
T
HNF
Y
GT
--
-
---
D
SD
Y
D
D
S
T
T
D
T
ATMRF
EH
DINDNTTIRNT
TR
W
SR
VK
QD
YLMT
A
IM
G
-----
G
ASNITQPT
S
-------
D
V
N
S
W
T
W
S
RTA
NT
K
D
VSNKI
L
T
--
NQT
NLTS
TF
YT
GS
IG
HDV
S
T
G
V
E
FTR
E
T
Q
TNYGV
N
PVT
L
PAV
N
I
YHP
DSS
I
HP
G
GL
T
R
NG
------------------
A
N
A
N
GQ
TD
TFA
I
YA
FD
T
LQ
I
T
R
D
F
E
L
N
GG
I
R
L
D
-
-
-----
NYH
TEYDSATAC
G
G
S
G
RGAI
T
CPT
G
V
A
KG
SPVTTVDTAKSGNLVN
W
KA
G
ALY
H
LT
E
N
GN
V
YI
N
YA
VSQQ
P
P
G
G
N
NF
A
LA
Q
S
G
SGNSANRT
DFK
PQ
K
ANT
S
EIGT
KWQ
VL
D
K
R
L
L
LT
A
A
L
FR
T
D
IE
N
EV
E
-
-
-
-
--
-
QN
DD
GT
----
Y
S
Q
Y
GK
K
R
VEG
Y
E
I
S
VAGNIT
P
----
--A
W
QV
I
G
G
Y
---
T
Q
Q
K
A
T
IKNG
K
D
VAQDG
S
S
S
LP
YT
PE
H
AFT
L
WSQY
QA
TD
D
I
S
V
G
AGA
R
Y
I
G
S--
-
---
-
M
H
KG
SDGAV
G
TPAFTE
G
-
Y
WVA
D
A
K
LG
Y
R
V
N
R
NL
D
FQLN
V
Y
NLFD
-
-
-
------
-
-
-
-
---
-
T
D
YVA
SI
N
KSG
Y
R
Y
H
PG
EP
RT
FL
L
TA
N
M
HF
fig|340186.3.peg.2581
Escherichia coli E110019 (10-760/760)
RQF
HSLT
FFAG
L
-
CI
G
IT
-
P
V
A
Q
A
LA
A
E
GQTNA
DDTLVV
E
A
-
S
T
P
SL
-
Y
AP
QQ
S
ADP
KFSRPVADTTRTM
TV
I
S
EQVI
KD
Q
GAT
NLT
D
AL
K
N
V
PGV
G
A
FFA
GE
N
GNST
T
G
D
-----
A
I
Y
M
RG
ADTS
N
S-
------
IYIDG
-
-
IR
D
I
G
SV
----
--S
RDT
FN
---------
T
E
Q
VEV
IK
GP
S
GT
D
YG
R
SA
P
T
G
S
IN
M
I
S
KQP
RN---
-
--
D
S
G
I
D
A
SA
S
IGSAWFR
R
GT
L
D
V
N
QV
I
-
GD
TTAV
RL
NV
MGE
--
KT
H
D
-
---
--
-
--
-
-----
---------
AGR
DK
V
K
N
E
-----
-
R
YGV
AP
--
S
IAFGL
G
TANRLY
L
N
Y
LHV
TQ
HNTP
D
GGIPTIGLPGYSAPS
AG
T
AA
LN
HS
G
K
V
D
T
HNF
Y
GT
--
-
---
D
SD
Y
D
D
S
T
T
D
T
ATMRF
EH
DINDNTTIRNT
TR
W
SR
VK
QD
YLMT
A
IM
G
-----
G
ASNITQPT
S
-------
D
V
N
S
W
T
W
S
RTA
NT
K
D
VSNKI
L
T
--
NQT
NLTS
TF
YT
GS
IG
HDV
S
T
G
V
E
FTR
E
T
Q
TNYGV
N
PVT
L
PAV
N
I
YHP
DSS
I
HP
G
GL
T
R
NG
------------------
A
N
A
N
GQ
TD
TFA
I
YA
FD
T
LQ
I
T
R
D
F
E
L
N
GG
I
R
L
D
-
-
-----
NYH
TEYDSATAC
G
G
S
G
RGAI
T
CPT
G
V
A
KG
SPVTTVDTAKSGNLVN
W
KA
G
ALY
H
LT
E
N
GN
V
YI
N
YA
VSQQ
P
P
G
G
N
NF
A
LA
Q
S
G
SGNSANRT
DFK
PQ
K
ANT
S
EIGT
KWQ
VL
D
K
R
L
L
LT
A
A
L
FR
T
D
IE
N
EV
E
-
-
-
-
--
-
QN
DD
GT
----
Y
S
Q
Y
GK
K
R
VEG
Y
E
I
S
VAGNIT
P
----
--A
W
QV
I
G
G
Y
---
T
Q
Q
K
A
T
IKNG
K
D
VAQDG
S
S
S
LP
YT
PE
H
AFT
L
WSQY
QA
TD
D
I
S
V
G
AGA
R
Y
I
G
S--
-
---
-
M
H
KG
SDGAV
G
TPAFTE
G
-
Y
WVA
D
A
K
LG
Y
R
V
N
R
NL
D
FQLN
V
Y
NLFD
-
-
-
------
-
-
-
-
---
-
T
D
YVA
SI
N
KSG
Y
R
Y
H
PG
EP
RT
FL
L
TA
N
M
HF
fig|656417.3.peg.991
Escherichia coli M605 (10-760/760)
RQF
HSLT
FFAG
L
-
CI
G
IT
-
P
V
A
Q
A
LA
A
E
GQANA
DDTLVV
E
A
-
S
T
P
SL
-
Y
AP
QK
S
ADP
KFSRPVADTTRTM
TV
I
S
EQVI
KD
Q
GAT
NLT
D
AL
K
N
V
PGV
G
A
FFA
GE
N
GNST
T
G
D
-----
A
I
Y
M
RG
ADTS
N
S-
------
IYIDG
-
-
IR
D
I
G
SV
----
--S
RDT
FN
---------
T
E
Q
VEV
IK
GP
S
GT
D
YG
R
SA
P
T
G
S
IN
M
I
S
KQP
RN---
-
--
D
S
G
I
D
A
SA
S
IGSAWFR
R
GT
L
D
V
N
QV
I
-
GD
TTAV
RL
NV
MGE
--
KT
H
D
-
---
--
-
--
-
-----
---------
AGR
DK
V
K
N
E
-----
-
R
YGV
AP
--
S
VAFGL
G
TANRLY
L
N
Y
LHV
TQ
HNTP
D
GGIPTIGLPGYSAPS
AG
T
AA
LN
HS
G
K
V
D
T
HNF
Y
GT
--
-
---
D
SD
Y
D
D
S
T
T
D
T
ATMRF
EH
DINDNTTIRNT
TR
W
SR
VK
QD
YLMT
A
IM
G
-----
G
ASNITQPA
S
-------
D
V
N
S
W
T
W
S
RTA
NT
K
D
VSNKI
L
T
--
NQT
NLTS
TF
YT
G
A
IG
HDV
S
T
G
V
E
FTR
E
T
Q
TNYGV
N
PVT
L
PAV
N
I
YHP
DSS
I
HP
G
GL
T
R
NG
------------------
A
N
A
N
GQ
TD
TFA
I
YA
FD
T
LQ
I
T
R
D
F
E
L
N
GG
I
R
L
D
-
-
-----
NYH
TEYDSATAC
G
G
S
G
RGAI
T
CPA
G
V
A
KG
SPVTTVDTAKSGNLVN
W
KA
G
ALY
H
LT
E
N
GN
V
YI
N
YA
VSQQ
P
P
G
G
N
NF
A
LA
Q
S
G
SGNSANRT
DFK
PQ
K
ANT
S
EIGT
KWQ
VL
D
K
R
L
L
LT
A
A
L
FR
T
D
IE
N
EV
E
-
-
-
-
--
-
QN
DD
GT
----
Y
S
Q
Y
GK
K
R
VEG
Y
E
I
S
VAGNIT
P
----
--A
W
QM
I
G
G
Y
---
T
Q
Q
K
A
T
IKNG
K
D
VAQDG
S
S
S
LP
YT
PE
H
AFT
L
WSQY
QA
TD
D
I
S
V
G
AGA
R
Y
I
G
S--
-
---
-
M
H
KG
SDGAV
G
TPAFTE
G
-
Y
WVA
D
A
K
LG
Y
R
V
N
R
NL
D
FQLN
V
Y
NLFD
-
-
-
------
-
-
-
-
---
-
T
D
YVA
SI
N
KSG
Y
R
Y
H
PG
EP
RT
FL
L
TA
N
M
HF
fig|749527.3.peg.4375
Escherichia coli MS 21-1 (10-760/760)
RQF
HSLT
FFAG
L
-
CI
G
IT
-
P
V
A
Q
A
LA
A
E
GQTNV
DDTLVV
E
A
-
S
T
P
SL
-
Y
AP
QQ
S
ADP
KFSRPVADTTRTM
TV
I
S
EQVI
KD
Q
GAT
NLT
D
AL
K
N
V
PGV
G
A
FFA
GE
N
GNST
T
G
D
-----
A
I
Y
M
RG
ADTS
N
S-
------
IYIDG
-
-
IR
D
I
G
SV
----
--S
RDT
FN
---------
T
E
Q
VEV
IK
GP
S
GT
D
YG
R
SA
P
T
G
S
IN
M
I
S
KQP
RN---
-
--
D
S
G
I
D
A
SA
S
IGSAWFR
R
GT
L
D
V
N
QV
I
-
GD
TTAV
RL
NV
MGE
--
KT
H
D
-
---
--
-
--
-
-----
---------
AGR
DK
V
K
N
E
-----
-
R
YGV
AP
--
S
VAFGL
G
TANRLY
L
N
Y
LHV
TQ
HNTP
D
GGIPTIGLPGYSAPS
AG
T
AA
LN
HS
G
K
V
D
T
HNF
Y
GT
--
-
---
D
SD
Y
D
D
S
T
T
D
T
ATMRF
EH
DINDNTTIRNT
TR
W
SR
VK
QD
YLMT
A
IM
G
-----
G
ASNITQPT
S
-------
D
V
N
S
W
T
W
S
RTA
NT
K
D
VSNKI
L
T
--
NQT
NLTS
TF
YT
GS
IG
HDV
S
T
G
V
E
FTR
E
T
Q
TNYGV
N
PVT
L
PAV
N
I
YHP
DSS
I
HP
G
GL
T
R
NG
------------------
A
N
A
N
GQ
TD
TFA
I
YA
FD
T
LQ
I
T
R
D
F
E
L
N
GG
I
R
L
D
-
-
-----
NYH
TEYDSATAC
G
G
S
G
RGAI
T
CPA
G
V
A
KG
SPVTTVDTAKSGNLVN
W
KA
G
ALY
H
LT
E
N
GN
I
YI
N
YA
VSQQ
P
P
G
G
N
NF
A
LA
Q
S
G
SGNSANRT
DFK
PQ
K
ANT
S
EIGT
KWQ
VL
D
K
R
L
L
LT
A
A
L
FR
T
D
IE
N
EV
E
-
-
-
-
--
-
QN
DD
GT
----
Y
S
Q
Y
GK
K
R
VEG
Y
E
I
S
VAGNIT
P
----
--A
W
QV
I
G
G
Y
---
T
Q
Q
K
A
T
IKNG
K
D
VAQDG
S
S
S
LP
YT
PE
H
AFT
L
WSQY
QA
TD
D
I
S
V
G
AGA
R
Y
I
G
S--
-
---
-
M
H
KG
SDGAV
G
TPAFTE
G
-
Y
WVA
D
A
K
LG
Y
R
V
N
R
NL
D
FQLN
V
Y
NLFD
-
-
-
------
-
-
-
-
---
-
T
D
YVA
SI
N
KSG
Y
R
Y
H
PG
EP
RT
FL
L
TA
N
M
HF
fig|656419.3.peg.1088
Escherichia coli M718 (10-760/760)
RQF
HSLT
FFAG
L
-
CI
G
IT
-
P
V
A
Q
A
LA
A
E
GQTNA
DDTLVV
E
A
-
S
T
P
SL
-
Y
AP
QQ
S
ADP
KFSRPVADTTRTM
TV
I
S
EQVI
KD
Q
GAT
NLT
D
AL
K
N
V
PGV
G
A
FFA
GE
N
GNST
T
G
D
-----
A
I
Y
M
RG
ADTS
N
S-
------
IYIDG
-
-
IR
D
I
G
SV
----
--S
RDT
FN
---------
T
E
Q
VEV
IK
GP
S
GT
D
YG
R
SA
P
T
G
S
IN
M
I
S
KQP
RN---
-
--
D
S
G
I
D
A
SA
S
IGSAWFR
R
GT
L
D
V
N
QV
I
-
GD
TTAV
RL
NV
MGE
--
KT
H
D
-
---
--
-
--
-
-----
---------
AGR
DK
V
K
N
E
-----
-
R
YGV
AP
--
S
VAFGL
G
TANRLY
L
N
Y
LHV
TQ
HNTP
D
GGIPTIGLPGYSAPS
AG
T
AT
LN
HS
G
K
V
D
T
HNF
Y
GT
--
-
---
D
SD
Y
D
D
S
T
T
D
T
ATMRF
EH
DINDNTTIRNT
TR
W
SR
VK
QD
YLMT
A
IM
G
-----
G
ASNITQPT
S
-------
D
V
N
S
W
T
W
S
RTA
NT
K
D
VSNKI
L
T
--
NQT
NLTS
TF
YT
GS
IG
HDV
S
T
G
V
E
FTR
E
T
Q
TNYGV
N
PVT
L
PAV
N
I
YHP
DSS
I
HP
G
GL
T
R
NG
------------------
A
N
A
N
GQ
TD
TFA
I
YA
FD
T
LQ
I
T
R
D
F
E
L
N
GG
I
R
L
D
-
-
-----
NYH
TEYDSATAC
G
G
S
G
RGAI
T
CPA
G
V
A
KG
SPVTTVDTAKSGNLVN
W
KA
G
ALY
H
LT
E
N
GN
V
YI
N
YA
VSQQ
P
P
G
G
N
NF
A
LA
Q
S
G
SGNSANRT
DFK
PQ
K
ANT
S
EIGT
KWQ
VL
D
K
R
L
L
LT
A
A
L
FR
T
D
IE
N
EV
E
-
-
-
-
--
-
QN
DD
GT
----
Y
S
Q
Y
GK
K
R
VEG
Y
E
I
S
VAGNIT
P
----
--A
W
QV
I
G
G
Y
---
T
Q
Q
K
A
T
IKNG
K
D
VAQDG
S
S
S
LP
YT
PE
H
AFT
L
WSQY
QA
TD
D
I
S
V
G
AGA
R
Y
I
G
S--
-
---
-
M
H
KG
SDGAV
G
TPAFTE
G
-
Y
WVA
D
A
K
LG
Y
R
V
N
R
NL
D
FQLN
V
Y
NLFD
-
-
-
------
-
-
-
-
---
-
T
D
YVA
SI
N
KSG
Y
R
Y
H
PG
EP
RT
FL
L
TA
N
M
HF
fig|679204.3.peg.5067
Escherichia coli MS 145-7 (10-760/760)
RQF
HSLT
FFAG
L
-
CI
G
IT
-
P
V
A
Q
A
LA
A
E
GQTNA
DDTLVV
E
A
-
S
T
P
SL
-
Y
AP
QQ
S
ADP
KFSRPVADTTRTM
TV
I
S
EQVI
KD
Q
GAT
NLT
D
AL
K
N
V
PGV
G
A
FFA
GE
N
GNST
T
G
D
-----
A
I
Y
M
RG
ADTS
N
S-
------
IYIDG
-
-
IR
D
I
G
SV
----
--S
RDT
FN
---------
T
E
Q
VEV
IK
GP
S
GT
D
YG
R
SA
P
T
G
S
IN
M
I
S
KQP
RN---
-
--
D
S
G
I
D
A
SA
S
IGSAWFR
R
GT
L
D
V
N
QV
I
-
GD
TTAV
RL
NV
MGE
--
KT
H
D
-
---
--
-
--
-
-----
---------
A
R
R
DK
V
K
N
E
-----
-
R
YGV
AP
--
S
IAFGL
G
TANRLY
L
N
Y
LHV
TQ
HNTP
D
GGIPTIGLPGYSAPS
AG
T
AA
LN
HS
G
K
V
D
T
HNF
Y
GT
--
-
---
D
SD
Y
D
D
S
T
T
D
T
ATMRF
EH
DINDNTTIRNT
TR
W
SR
VK
QD
YLMT
A
IM
G
-----
G
ASNITQPT
S
-------
D
V
N
S
W
T
W
S
RTA
NT
K
D
VSNKI
L
T
--
NQT
NLTS
TF
YT
GS
IG
HDV
S
T
G
V
E
FTR
E
T
Q
TNYGV
N
PVT
L
PAV
N
I
YHP
DSS
I
HP
G
GL
T
R
NG
------------------
A
N
A
N
GQ
TD
TFA
I
YA
FD
T
LQ
I
T
R
D
F
E
L
N
GG
I
R
L
D
-
-
-----
NYH
TEYDSATAC
G
G
S
G
RGAI
T
CPA
G
V
A
KG
SPVTTVDTAKSGNLVN
W
KA
G
ALY
H
LT
E
N
GN
V
YI
N
YA
VSQQ
P
P
G
G
N
NF
A
LA
Q
S
G
SGNSANRT
DFK
PQ
K
ANT
S
EIGT
KWQ
VL
D
K
R
L
L
LT
A
A
L
FR
T
D
IE
N
EV
E
-
-
-
-
--
-
QN
DD
GT
----
Y
S
Q
Y
GK
K
R
VEG
Y
E
I
S
VAGNIT
P
----
--A
W
QV
I
G
G
Y
---
T
Q
Q
K
A
T
IKNG
K
D
VAQDG
S
S
S
LP
YT
PE
H
AFT
L
WSQY
QA
TD
D
I
S
V
G
AGA
R
Y
I
G
S--
-
---
-
M
H
KG
SDGAV
G
TPAFTE
G
-
Y
WVA
D
A
K
LG
Y
R
V
N
R
NL
D
FQLN
V
Y
NLFD
-
-
-
------
-
-
-
-
---
-
T
D
YVA
SI
N
KSG
Y
R
Y
H
PG
EP
RT
FL
L
TA
N
M
HF
fig|585034.4.peg.829
Escherichia coli IAI1 (10-760/760)
RQF
HSLT
FFAG
L
-
CI
G
IT
-
P
V
A
Q
A
LA
A
E
GQTNA
DDTLVV
E
A
-
S
T
P
SL
-
Y
AP
QQ
S
ADP
KFSRPVADTTRTM
TV
I
S
EQVI
KD
Q
GAT
NLT
D
AL
K
N
V
PGV
G
A
FFA
GE
N
GNST
T
G
D
-----
A
I
Y
M
RG
ADTS
N
S-
------
IYIDG
-
-
IR
D
I
G
SV
----
--S
RDT
FN
---------
T
E
Q
VEV
IK
GP
S
GT
D
YG
R
SA
P
T
G
S
IN
M
I
S
KQP
RN---
-
--
D
S
G
I
D
A
SA
S
IGSAWFR
R
GT
L
D
V
N
QV
I
-
GD
TTAV
RL
NV
MGE
--
KT
H
D
-
---
--
-
--
-
-----
---------
AGR
DK
V
K
N
E
-----
-
R
YGV
AP
--
S
IAFGL
G
TANRLY
L
N
Y
LHV
TQ
HNTP
D
GGIPTIGLPGYSAPS
AG
T
AA
LN
HS
G
K
V
D
T
HNF
Y
GT
--
-
---
D
SD
Y
D
D
S
T
T
D
T
ATMRF
EH
DINDNTTIRNT
TR
W
SR
VK
QD
YLMT
A
IM
G
-----
G
ASNITQPT
S
-------
D
V
N
S
W
T
W
S
RTA
NT
K
D
VSNKI
L
T
--
NQT
NLTS
TF
YT
GS
IG
HDV
S
T
G
V
E
FTR
E
T
Q
TNYGV
N
PVT
L
PAV
N
I
YHP
DSS
I
HP
G
GL
T
R
NG
------------------
A
N
A
N
GQ
TD
TFA
I
YA
FD
T
LQ
I
T
R
D
F
E
L
N
GG
I
R
L
D
-
-
-----
NYH
TEYDSATAC
G
G
S
G
RGAI
T
CPA
G
V
A
KG
SPVTTVDTAKSGNLVN
W
KA
G
ALY
H
LT
E
N
GN
V
YI
N
YA
VSQQ
P
P
G
G
N
NF
A
LA
Q
S
G
SGNSANRT
DFK
PQ
K
ANT
S
EIGT
KWQ
VL
D
K
R
L
L
LT
A
A
L
FR
T
D
IE
N
EV
E
-
-
-
-
--
-
QN
DD
GT
----
Y
S
Q
Y
GK
K
R
VEG
Y
E
I
S
VAGNIT
P
----
--A
W
LV
I
G
G
Y
---
T
Q
Q
K
A
T
IKNG
K
D
VAQDG
S
S
S
LP
YT
PE
H
AFT
L
WSQY
QA
TD
D
I
S
V
G
AGA
R
Y
I
G
S--
-
---
-
M
H
KG
SDGAV
G
TPAFTE
G
-
Y
WVA
D
A
K
LG
Y
R
V
N
R
NL
D
FQLN
V
Y
NLFD
-
-
-
------
-
-
-
-
---
-
T
D
YVA
SI
N
KSG
Y
R
Y
H
PG
EP
RT
FL
L
TA
N
M
HF
fig|585034.5.peg.825
Escherichia coli IAI1 (10-760/760)
RQF
HSLT
FFAG
L
-
CI
G
IT
-
P
V
A
Q
A
LA
A
E
GQTNA
DDTLVV
E
A
-
S
T
P
SL
-
Y
AP
QQ
S
ADP
KFSRPVADTTRTM
TV
I
S
EQVI
KD
Q
GAT
NLT
D
AL
K
N
V
PGV
G
A
FFA
GE
N
GNST
T
G
D
-----
A
I
Y
M
RG
ADTS
N
S-
------
IYIDG
-
-
IR
D
I
G
SV
----
--S
RDT
FN
---------
T
E
Q
VEV
IK
GP
S
GT
D
YG
R
SA
P
T
G
S
IN
M
I
S
KQP
RN---
-
--
D
S
G
I
D
A
SA
S
IGSAWFR
R
GT
L
D
V
N
QV
I
-
GD
TTAV
RL
NV
MGE
--
KT
H
D
-
---
--
-
--
-
-----
---------
AGR
DK
V
K
N
E
-----
-
R
YGV
AP
--
S
IAFGL
G
TANRLY
L
N
Y
LHV
TQ
HNTP
D
GGIPTIGLPGYSAPS
AG
T
AA
LN
HS
G
K
V
D
T
HNF
Y
GT
--
-
---
D
SD
Y
D
D
S
T
T
D
T
ATMRF
EH
DINDNTTIRNT
TR
W
SR
VK
QD
YLMT
A
IM
G
-----
G
ASNITQPT
S
-------
D
V
N
S
W
T
W
S
RTA
NT
K
D
VSNKI
L
T
--
NQT
NLTS
TF
YT
GS
IG
HDV
S
T
G
V
E
FTR
E
T
Q
TNYGV
N
PVT
L
PAV
N
I
YHP
DSS
I
HP
G
GL
T
R
NG
------------------
A
N
A
N
GQ
TD
TFA
I
YA
FD
T
LQ
I
T
R
D
F
E
L
N
GG
I
R
L
D
-
-
-----
NYH
TEYDSATAC
G
G
S
G
RGAI
T
CPA
G
V
A
KG
SPVTTVDTAKSGNLVN
W
KA
G
ALY
H
LT
E
N
GN
V
YI
N
YA
VSQQ
P
P
G
G
N
NF
A
LA
Q
S
G
SGNSANRT
DFK
PQ
K
ANT
S
EIGT
KWQ
VL
D
K
R
L
L
LT
A
A
L
FR
T
D
IE
N
EV
E
-
-
-
-
--
-
QN
DD
GT
----
Y
S
Q
Y
GK
K
R
VEG
Y
E
I
S
VAGNIT
P
----
--A
W
LV
I
G
G
Y
---
T
Q
Q
K
A
T
IKNG
K
D
VAQDG
S
S
S
LP
YT
PE
H
AFT
L
WSQY
QA
TD
D
I
S
V
G
AGA
R
Y
I
G
S--
-
---
-
M
H
KG
SDGAV
G
TPAFTE
G
-
Y
WVA
D
A
K
LG
Y
R
V
N
R
NL
D
FQLN
V
Y
NLFD
-
-
-
------
-
-
-
-
---
-
T
D
YVA
SI
N
KSG
Y
R
Y
H
PG
EP
RT
FL
L
TA
N
M
HF
fig|358709.5.peg.3083
Escherichia coli 101-1 (10-760/760)
RQF
HSLT
FFAG
L
-
CI
G
IT
-
P
V
A
Q
A
LA
A
E
GQANA
DDTLVV
E
A
-
S
T
P
SL
-
Y
AP
QQ
S
ADP
KFSRPVADTTRTM
TV
I
S
EQVI
KD
Q
GAT
NLT
D
AL
K
N
V
PGV
G
A
FFA
GE
N
GNST
T
G
D
-----
A
I
Y
M
RG
ADTS
N
S-
------
IYIDG
-
-
IR
D
I
G
SV
----
--S
RDT
FN
---------
T
E
Q
VEV
IK
GP
S
GT
D
YG
R
SA
P
T
G
S
IN
M
I
S
KQP
RN---
-
--
D
S
G
I
D
A
SA
S
IGSAWFR
R
GT
L
D
V
N
QV
I
-
GD
TTAV
RL
NV
MGE
--
KT
H
D
-
---
--
-
--
-
-----
---------
AGR
DK
V
K
N
E
-----
-
R
YGV
AP
--
S
VAFGL
G
TANRLY
L
N
Y
LHV
TQ
HNTP
D
GGIPTIGLPGYSAPS
AG
T
AA
LN
HS
G
K
V
D
T
HNF
Y
GT
--
-
---
D
SD
Y
D
D
S
T
T
D
T
ATMRF
EH
DINDNTTIRNT
TR
W
SR
VK
QD
YLMT
A
IM
G
-----
G
ASNITQPT
S
-------
D
V
N
S
W
T
W
S
RTA
NT
K
D
VSNKI
L
T
--
NQT
NLTS
TF
YT
GS
IG
HDV
S
T
G
V
E
FTR
E
T
Q
TNYGV
N
PVT
L
PAV
N
I
YHP
DSS
I
HP
G
GL
T
R
NG
------------------
A
N
A
N
GQ
TD
TFA
I
YA
FD
T
LQ
I
T
R
D
F
E
L
N
GG
I
R
L
D
-
-
-----
NYH
TEYDSATAC
G
G
S
G
RGAI
T
CPV
G
V
A
KG
SPVTTVDTA
R
SGNLVN
W
KA
G
ALY
H
LT
E
N
GN
V
YI
N
YA
VSQQ
P
P
G
G
N
NF
A
LA
Q
S
G
SGNSANRT
DFK
PQ
K
ANT
S
EIGT
KWQ
VL
D
K
R
L
L
LT
A
A
L
FR
T
D
IE
N
EV
E
-
-
-
-
--
-
QN
DD
GT
----
Y
S
Q
Y
GK
K
R
VEG
Y
E
I
S
VAGNIT
P
----
--A
W
QV
I
G
G
Y
---
T
Q
Q
K
A
T
IKNG
K
D
VAQDG
S
S
S
LP
YT
PE
H
AFT
L
WSQY
QA
TD
D
I
S
V
G
AGA
R
Y
I
G
S--
-
---
-
M
H
KG
SDGAV
G
TPAFTE
G
-
Y
WVA
D
A
K
LG
Y
R
V
N
R
NL
D
FQLN
V
Y
NLFD
-
-
-
------
-
-
-
-
---
-
T
D
YVA
SI
N
KSG
Y
R
Y
H
PG
EP
RT
FL
L
TA
N
M
HF
fig|413997.3.peg.815
Escherichia coli B str. REL606 (10-760/760)
RQF
HSLT
FFAG
L
-
CI
G
IT
-
P
V
A
Q
A
LA
A
E
GQANA
DDTLVV
E
A
-
S
T
P
SL
-
Y
AP
QQ
S
ADP
KFSRPVADTTRTM
TV
I
S
EQVI
KD
Q
GAT
NLT
D
AL
K
N
V
PGV
G
A
FFA
GE
N
GNST
T
G
D
-----
A
I
Y
M
RG
ADTS
N
S-
------
IYIDG
-
-
IR
D
I
G
SV
----
--S
RDT
FN
---------
T
E
Q
VEV
IK
GP
S
GT
D
YG
R
SA
P
T
G
S
IN
M
I
S
KQP
RN---
-
--
D
S
G
I
D
A
SA
S
IGSAWFR
R
GT
L
D
V
N
QV
I
-
GD
TTAV
RL
NV
MGE
--
KT
H
D
-
---
--
-
--
-
-----
---------
AGR
DK
V
K
N
E
-----
-
R
YGV
AP
--
S
VAFGL
G
TANRLY
L
N
Y
LHV
TQ
HNTP
D
GGIPTIGLPGYSAPS
AG
T
AA
LN
HS
G
K
V
D
T
HNF
Y
GT
--
-
---
D
SD
Y
D
D
S
T
T
D
T
ATMRF
EH
DINDNTTIRNT
TR
W
SR
VK
QD
YLMT
A
IM
G
-----
G
ASNITQPT
S
-------
D
V
N
S
W
T
W
S
RTA
NT
K
D
VSNKI
L
T
--
NQT
NLTS
TF
YT
GS
IG
HDV
S
T
G
V
E
FTR
E
T
Q
TNYGV
N
PVT
L
PAV
N
I
YHP
DSS
I
HP
G
GL
T
R
NG
------------------
A
N
A
N
GQ
TD
TFA
I
YA
FD
T
LQ
I
T
R
D
F
E
L
N
GG
I
R
L
D
-
-
-----
NYH
TEYDSATAC
G
G
S
G
RGAI
T
CPV
G
V
A
KG
SPVTTVDTA
R
SGNLVN
W
KA
G
ALY
H
LT
E
N
GN
V
YI
N
YA
VSQQ
P
P
G
G
N
NF
A
LA
Q
S
G
SGNSANRT
DFK
PQ
K
ANT
S
EIGT
KWQ
VL
D
K
R
L
L
LT
A
A
L
FR
T
D
IE
N
EV
E
-
-
-
-
--
-
QN
DD
GT
----
Y
S
Q
Y
GK
K
R
VEG
Y
E
I
S
VAGNIT
P
----
--A
W
QV
I
G
G
Y
---
T
Q
Q
K
A
T
IKNG
K
D
VAQDG
S
S
S
LP
YT
PE
H
AFT
L
WSQY
QA
TD
D
I
S
V
G
AGA
R
Y
I
G
S--
-
---
-
M
H
KG
SDGAV
G
TPAFTE
G
-
Y
WVA
D
A
K
LG
Y
R
V
N
R
NL
D
FQLN
V
Y
NLFD
-
-
-
------
-
-
-
-
---
-
T
D
YVA
SI
N
KSG
Y
R
Y
H
PG
EP
RT
FL
L
TA
N
M
HF
fig|511693.5.peg.843
Escherichia coli BL21 (10-760/760)
RQF
HSLT
FFAG
L
-
CI
G
IT
-
P
V
A
Q
A
LA
A
E
GQANA
DDTLVV
E
A
-
S
T
P
SL
-
Y
AP
QQ
S
ADP
KFSRPVADTTRTM
TV
I
S
EQVI
KD
Q
GAT
NLT
D
AL
K
N
V
PGV
G
A
FFA
GE
N
GNST
T
G
D
-----
A
I
Y
M
RG
ADTS
N
S-
------
IYIDG
-
-
IR
D
I
G
SV
----
--S
RDT
FN
---------
T
E
Q
VEV
IK
GP
S
GT
D
YG
R
SA
P
T
G
S
IN
M
I
S
KQP
RN---
-
--
D
S
G
I
D
A
SA
S
IGSAWFR
R
GT
L
D
V
N
QV
I
-
GD
TTAV
RL
NV
MGE
--
KT
H
D
-
---
--
-
--
-
-----
---------
AGR
DK
V
K
N
E
-----
-
R
YGV
AP
--
S
VAFGL
G
TANRLY
L
N
Y
LHV
TQ
HNTP
D
GGIPTIGLPGYSAPS
AG
T
AA
LN
HS
G
K
V
D
T
HNF
Y
GT
--
-
---
D
SD
Y
D
D
S
T
T
D
T
ATMRF
EH
DINDNTTIRNT
TR
W
SR
VK
QD
YLMT
A
IM
G
-----
G
ASNITQPT
S
-------
D
V
N
S
W
T
W
S
RTA
NT
K
D
VSNKI
L
T
--
NQT
NLTS
TF
YT
GS
IG
HDV
S
T
G
V
E
FTR
E
T
Q
TNYGV
N
PVT
L
PAV
N
I
YHP
DSS
I
HP
G
GL
T
R
NG
------------------
A
N
A
N
GQ
TD
TFA
I
YA
FD
T
LQ
I
T
R
D
F
E
L
N
GG
I
R
L
D
-
-
-----
NYH
TEYDSATAC
G
G
S
G
RGAI
T
CPV
G
V
A
KG
SPVTTVDTA
R
SGNLVN
W
KA
G
ALY
H
LT
E
N
GN
V
YI
N
YA
VSQQ
P
P
G
G
N
NF
A
LA
Q
S
G
SGNSANRT
DFK
PQ
K
ANT
S
EIGT
KWQ
VL
D
K
R
L
L
LT
A
A
L
FR
T
D
IE
N
EV
E
-
-
-
-
--
-
QN
DD
GT
----
Y
S
Q
Y
GK
K
R
VEG
Y
E
I
S
VAGNIT
P
----
--A
W
QV
I
G
G
Y
---
T
Q
Q
K
A
T
IKNG
K
D
VAQDG
S
S
S
LP
YT
PE
H
AFT
L
WSQY
QA
TD
D
I
S
V
G
AGA
R
Y
I
G
S--
-
---
-
M
H
KG
SDGAV
G
TPAFTE
G
-
Y
WVA
D
A
K
LG
Y
R
V
N
R
NL
D
FQLN
V
Y
NLFD
-
-
-
------
-
-
-
-
---
-
T
D
YVA
SI
N
KSG
Y
R
Y
H
PG
EP
RT
FL
L
TA
N
M
HF
fig|469008.4.peg.2918
Escherichia coli BL21(DE3) (10-760/760)
RQF
HSLT
FFAG
L
-
CI
G
IT
-
P
V
A
Q
A
LA
A
E
GQANA
DDTLVV
E
A
-
S
T
P
SL
-
Y
AP
QQ
S
ADP
KFSRPVADTTRTM
TV
I
S
EQVI
KD
Q
GAT
NLT
D
AL
K
N
V
PGV
G
A
FFA
GE
N
GNST
T
G
D
-----
A
I
Y
M
RG
ADTS
N
S-
------
IYIDG
-
-
IR
D
I
G
SV
----
--S
RDT
FN
---------
T
E
Q
VEV
IK
GP
S
GT
D
YG
R
SA
P
T
G
S
IN
M
I
S
KQP
RN---
-
--
D
S
G
I
D
A
SA
S
IGSAWFR
R
GT
L
D
V
N
QV
I
-
GD
TTAV
RL
NV
MGE
--
KT
H
D
-
---
--
-
--
-
-----
---------
AGR
DK
V
K
N
E
-----
-
R
YGV
AP
--
S
VAFGL
G
TANRLY
L
N
Y
LHV
TQ
HNTP
D
GGIPTIGLPGYSAPS
AG
T
AA
LN
HS
G
K
V
D
T
HNF
Y
GT
--
-
---
D
SD
Y
D
D
S
T
T
D
T
ATMRF
EH
DINDNTTIRNT
TR
W
SR
VK
QD
YLMT
A
IM
G
-----
G
ASNITQPT
S
-------
D
V
N
S
W
T
W
S
RTA
NT
K
D
VSNKI
L
T
--
NQT
NLTS
TF
YT
GS
IG
HDV
S
T
G
V
E
FTR
E
T
Q
TNYGV
N
PVT
L
PAV
N
I
YHP
DSS
I
HP
G
GL
T
R
NG
------------------
A
N
A
N
GQ
TD
TFA
I
YA
FD
T
LQ
I
T
R
D
F
E
L
N
GG
I
R
L
D
-
-
-----
NYH
TEYDSATAC
G
G
S
G
RGAI
T
CPV
G
V
A
KG
SPVTTVDTA
R
SGNLVN
W
KA
G
ALY
H
LT
E
N
GN
V
YI
N
YA
VSQQ
P
P
G
G
N
NF
A
LA
Q
S
G
SGNSANRT
DFK
PQ
K
ANT
S
EIGT
KWQ
VL
D
K
R
L
L
LT
A
A
L
FR
T
D
IE
N
EV
E
-
-
-
-
--
-
QN
DD
GT
----
Y
S
Q
Y
GK
K
R
VEG
Y
E
I
S
VAGNIT
P
----
--A
W
QV
I
G
G
Y
---
T
Q
Q
K
A
T
IKNG
K
D
VAQDG
S
S
S
LP
YT
PE
H
AFT
L
WSQY
QA
TD
D
I
S
V
G
AGA
R
Y
I
G
S--
-
---
-
M
H
KG
SDGAV
G
TPAFTE
G
-
Y
WVA
D
A
K
LG
Y
R
V
N
R
NL
D
FQLN
V
Y
NLFD
-
-
-
------
-
-
-
-
---
-
T
D
YVA
SI
N
KSG
Y
R
Y
H
PG
EP
RT
FL
L
TA
N
M
HF
fig|749547.3.peg.1647
Escherichia coli MS 187-1 (10-760/760)
RQF
HSLT
FFAG
L
-
CI
G
IT
-
P
V
A
Q
A
LA
A
E
GQANA
DDTLVV
E
A
-
S
T
P
SL
-
Y
AP
QQ
S
ADP
KFSRPVADTTRTM
TV
I
S
EQVI
KD
Q
GAT
NLT
D
AL
K
N
V
PGV
G
A
FFA
GE
N
GNST
T
G
D
-----
A
I
Y
M
RG
ADTS
N
S-
------
IYIDG
-
-
IR
D
I
G
SV
----
--S
RDT
FN
---------
T
E
Q
VEV
IK
GP
S
GT
D
YG
R
SA
P
T
G
S
IN
M
I
S
KQP
RN---
-
--
D
S
G
I
D
A
SA
S
IGSAWFR
R
GT
L
D
V
N
QV
I
-
GD
TTAV
RL
NV
MGE
--
KT
H
D
-
---
--
-
--
-
-----
---------
AGR
DK
V
K
N
E
-----
-
R
YGV
AP
--
S
VAFGL
G
TANRLY
L
N
Y
LHV
TQ
HNTP
D
GGIPTIGLPGYSAPS
AG
T
AA
LN
HS
G
K
V
D
T
HNF
Y
GT
--
-
---
D
SD
Y
D
D
S
T
T
D
T
ATMRF
EH
DINDNTTIRNT
TR
W
SR
VK
QD
YLMT
A
IM
G
-----
G
ASNITQPT
S
-------
D
V
N
S
W
T
W
S
RTA
NT
K
D
VSNKI
L
T
--
NQT
NLTS
TF
YT
GS
IG
HDV
S
T
G
V
E
FTR
E
T
Q
TNYGV
N
PVT
L
PAV
N
I
YHP
DSS
I
HP
G
GL
T
R
NG
------------------
A
N
A
N
GQ
TD
TFA
I
YA
FD
T
LQ
I
T
R
D
F
E
L
N
GG
I
R
L
D
-
-
-----
NYH
TEYDSATAC
G
G
S
G
RGAI
T
CPV
G
V
A
KG
SPVTTVDTA
R
SGNLVN
W
KA
G
ALY
H
LT
E
N
GN
V
YI
N
YA
VSQQ
P
P
G
G
N
NF
A
LA
Q
S
G
SGNSANRT
DFK
PQ
K
ANT
S
EIGT
KWQ
VL
D
K
R
L
L
LT
A
A
L
FR
T
D
IE
N
EV
E
-
-
-
-
--
-
QN
DD
GT
----
Y
S
Q
Y
GK
K
R
VEG
Y
E
I
S
VAGNIT
P
----
--A
W
QV
I
G
G
Y
---
T
Q
Q
K
A
T
IKNG
K
D
VAQDG
S
S
S
LP
YT
PE
H
AFT
L
WSQY
QA
TD
D
I
S
V
G
AGA
R
Y
I
G
S--
-
---
-
M
H
KG
SDGAV
G
TPAFTE
G
-
Y
WVA
D
A
K
LG
Y
R
V
N
R
NL
D
FQLN
V
Y
NLFD
-
-
-
------
-
-
-
-
---
-
T
D
YVA
SI
N
KSG
Y
R
Y
H
PG
EP
RT
FL
L
TA
N
M
HF
fig|637912.3.peg.1061
Escherichia coli OP50 (10-760/760)
RQF
HSLT
FFAG
L
-
CI
G
IT
-
P
V
A
Q
A
LA
A
E
GQANA
DDTLVV
E
A
-
S
T
P
SL
-
Y
AP
QQ
S
ADP
KFSRPVADTTRTM
TV
I
S
EQVI
KD
Q
GAT
NLT
D
AL
K
N
V
PGV
G
A
FFA
GE
N
GNST
T
G
D
-----
A
I
Y
M
RG
ADTS
N
S-
------
IYIDG
-
-
IR
D
I
G
SV
----
--S
RDT
FN
---------
T
E
Q
VEV
IK
GP
S
GT
D
YG
R
SA
P
T
G
S
IN
M
I
S
KQP
RN---
-
--
D
S
G
I
D
A
SA
S
IGSAWFR
R
GT
L
D
V
N
QV
I
-
GD
TTAV
RL
NV
MGE
--
KT
H
D
-
---
--
-
--
-
-----
---------
AGR
DK
V
K
N
E
-----
-
R
YGV
AP
--
S
VAFGL
G
TANRLY
L
N
Y
LHV
TQ
HNTP
D
GGIPTIGLPGYSAPS
AG
T
AA
LN
HS
G
K
V
D
T
HNF
Y
GT
--
-
---
D
SD
Y
D
D
S
T
T
D
T
ATMRF
EH
DINDNTTIRNT
TR
W
SR
VK
QD
YLMT
A
IM
G
-----
G
ASNITQPT
S
-------
D
V
N
S
W
T
W
S
RTA
NT
K
D
VSNKI
L
T
--
NQT
NLTS
TF
YT
GS
IG
HDV
S
T
G
V
E
FTR
E
T
Q
TNYGV
N
PVT
L
PAV
N
I
YHP
DSS
I
HP
G
GL
T
R
NG
------------------
A
N
A
N
GQ
TD
TFA
I
YA
FD
T
LQ
I
T
R
D
F
E
L
N
GG
I
R
L
D
-
-
-----
NYH
TEYDSATAC
G
G
S
G
RGAI
T
CPV
G
V
A
KG
SPVTTVDTA
R
SGNLVN
W
KA
G
ALY
H
LT
E
N
GN
V
YI
N
YA
VSQQ
P
P
G
G
N
NF
A
LA
Q
S
G
SGNSANRT
DFK
PQ
K
ANT
S
EIGT
KWQ
VL
D
K
R
L
L
LT
A
A
L
FR
T
D
IE
N
EV
E
-
-
-
-
--
-
QN
DD
GT
----
Y
S
Q
Y
GK
K
R
VEG
Y
E
I
S
VAGNIT
P
----
--A
W
QV
I
G
G
Y
---
T
Q
Q
K
A
T
IKNG
K
D
VAQDG
S
S
S
LP
YT
PE
H
AFT
L
WSQY
QA
TD
D
I
S
V
G
AGA
R
Y
I
G
S--
-
---
-
M
H
KG
SDGAV
G
TPAFTE
G
-
Y
WVA
D
A
K
LG
Y
R
V
N
R
NL
D
FQLN
V
Y
NLFD
-
-
-
------
-
-
-
-
---
-
T
D
YVA
SI
N
KSG
Y
R
Y
H
PG
EP
RT
FL
L
TA
N
M
HF
fig|340184.3.peg.1201
Escherichia coli B7A (10-760/760)
RQF
HSLT
FFAG
L
-
CI
G
IT
-
P
V
A
Q
A
LA
A
E
GQTNA
DDTLVV
E
A
-
S
T
P
SL
-
Y
AP
QQ
S
ADP
KFSRPVADTTRTM
TV
I
S
EQVI
KD
Q
GAT
NLI
D
AL
K
N
V
PGV
G
A
FFA
GE
N
GNST
T
G
D
-----
A
I
Y
M
RG
ADTS
N
S-
------
IYIDG
-
-
IR
D
I
G
SV
----
--S
RDT
FN
---------
T
E
Q
VEV
IK
GP
S
GT
D
YG
R
SA
P
T
G
S
IN
M
I
S
KQP
RN---
-
--
D
S
G
I
D
A
SA
S
IGSAWFR
R
GT
L
D
V
N
QV
I
-
GD
TTAV
RL
NV
MGE
--
KT
H
D
-
---
--
-
--
-
-----
---------
AGR
DK
V
K
N
E
-----
-
R
YGV
AP
--
S
IAFGL
G
TANRLY
L
N
Y
LHV
TQ
HNTP
D
GGIPTIGLPGYSAPS
AG
T
AA
LN
HS
G
K
V
D
T
HNF
Y
GT
--
-
---
D
SD
Y
D
D
S
T
T
D
T
ATMRF
EH
DINDNTTIRNT
TR
W
SR
VK
QD
YLMT
A
IM
G
-----
G
ASNITQPT
S
-------
D
V
N
S
W
T
W
S
RTA
NT
K
D
VSNKI
L
T
--
NQT
NLTS
TF
YT
GS
IG
HDV
S
T
G
V
E
FTR
E
T
Q
TNYGV
N
PVT
L
PAV
N
I
YHP
DSS
I
HP
G
GL
T
R
NG
------------------
A
N
A
N
GQ
TD
TFA
I
YA
FD
T
LQ
I
T
R
D
F
E
L
N
GG
I
R
L
D
-
-
-----
NYH
TEYDSATAC
G
G
S
G
RGAI
T
CPA
G
V
A
KG
SPVTTVDTAKSGNLVN
W
KA
G
ALY
H
LT
E
N
GN
V
YI
N
YA
VSQQ
P
P
G
G
N
NF
A
LA
Q
S
G
SGNSANRT
DFK
PQ
K
ANT
S
EIGT
KWQ
VL
D
K
R
L
L
LT
A
A
L
FR
T
D
IE
N
EV
E
-
-
-
-
--
-
QN
DD
GT
----
Y
S
Q
Y
GK
K
R
VEG
Y
E
I
S
VAGNIT
P
----
--A
W
QV
I
G
G
Y
---
T
Q
Q
K
A
T
IKNG
K
D
VAQDG
S
S
S
LP
YT
PE
H
AFT
L
WSQY
QA
TD
D
I
S
V
G
AGA
R
Y
I
G
S--
-
---
-
M
H
KG
SDGAV
G
TPAFTE
G
-
Y
WVA
D
A
K
LG
Y
R
V
N
R
NL
D
FQLN
V
Y
NLFD
-
-
-
------
-
-
-
-
---
-
T
D
YVA
SI
N
KSG
Y
R
Y
H
PG
EP
RT
FL
L
TA
N
M
HF
fig|340184.6.peg.1264
Escherichia coli B7A (10-760/760)
RQF
HSLT
FFAG
L
-
CI
G
IT
-
P
V
A
Q
A
LA
A
E
GQTNA
DDTLVV
E
A
-
S
T
P
SL
-
Y
AP
QQ
S
ADP
KFSRPVADTTRTM
TV
I
S
EQVI
KD
Q
GAT
NLI
D
AL
K
N
V
PGV
G
A
FFA
GE
N
GNST
T
G
D
-----
A
I
Y
M
RG
ADTS
N
S-
------
IYIDG
-
-
IR
D
I
G
SV
----
--S
RDT
FN
---------
T
E
Q
VEV
IK
GP
S
GT
D
YG
R
SA
P
T
G
S
IN
M
I
S
KQP
RN---
-
--
D
S
G
I
D
A
SA
S
IGSAWFR
R
GT
L
D
V
N
QV
I
-
GD
TTAV
RL
NV
MGE
--
KT
H
D
-
---
--
-
--
-
-----
---------
AGR
DK
V
K
N
E
-----
-
R
YGV
AP
--
S
IAFGL
G
TANRLY
L
N
Y
LHV
TQ
HNTP
D
GGIPTIGLPGYSAPS
AG
T
AA
LN
HS
G
K
V
D
T
HNF
Y
GT
--
-
---
D
SD
Y
D
D
S
T
T
D
T
ATMRF
EH
DINDNTTIRNT
TR
W
SR
VK
QD
YLMT
A
IM
G
-----
G
ASNITQPT
S
-------
D
V
N
S
W
T
W
S
RTA
NT
K
D
VSNKI
L
T
--
NQT
NLTS
TF
YT
GS
IG
HDV
S
T
G
V
E
FTR
E
T
Q
TNYGV
N
PVT
L
PAV
N
I
YHP
DSS
I
HP
G
GL
T
R
NG
------------------
A
N
A
N
GQ
TD
TFA
I
YA
FD
T
LQ
I
T
R
D
F
E
L
N
GG
I
R
L
D
-
-
-----
NYH
TEYDSATAC
G
G
S
G
RGAI
T
CPA
G
V
A
KG
SPVTTVDTAKSGNLVN
W
KA
G
ALY
H
LT
E
N
GN
V
YI
N
YA
VSQQ
P
P
G
G
N
NF
A
LA
Q
S
G
SGNSANRT
DFK
PQ
K
ANT
S
EIGT
KWQ
VL
D
K
R
L
L
LT
A
A
L
FR
T
D
IE
N
EV
E
-
-
-
-
--
-
QN
DD
GT
----
Y
S
Q
Y
GK
K
R
VEG
Y
E
I
S
VAGNIT
P
----
--A
W
QV
I
G
G
Y
---
T
Q
Q
K
A
T
IKNG
K
D
VAQDG
S
S
S
LP
YT
PE
H
AFT
L
WSQY
QA
TD
D
I
S
V
G
AGA
R
Y
I
G
S--
-
---
-
M
H
KG
SDGAV
G
TPAFTE
G
-
Y
WVA
D
A
K
LG
Y
R
V
N
R
NL
D
FQLN
V
Y
NLFD
-
-
-
------
-
-
-
-
---
-
T
D
YVA
SI
N
KSG
Y
R
Y
H
PG
EP
RT
FL
L
TA
N
M
HF
fig|216592.1.peg.3331
Escherichia coli 042 (10-760/760)
RQF
HSLT
FFAG
L
-
CI
S
IT
-
P
V
A
Q
A
LA
A
E
GQANA
DDTLVV
E
A
-
S
T
P
SL
-
Y
AP
QQ
S
ADP
KFSRPVADTTRTM
TV
I
S
EQVI
KD
Q
GAT
NLT
D
AL
K
N
V
PGV
G
A
FFA
GE
N
GNST
T
G
D
-----
A
I
Y
M
RG
ADTS
N
S-
------
IYIDG
-
-
IR
D
I
G
SV
----
--S
RDT
FN
---------
T
E
Q
VEV
IK
GP
S
GT
D
YG
R
SA
P
T
G
S
IN
M
I
S
KQP
RN---
-
--
D
S
G
I
D
A
SA
S
IGSAWFR
R
GT
L
D
V
N
QV
I
-
GD
TTAV
RL
NV
MGE
--
KT
H
D
-
---
--
-
--
-
-----
---------
AGR
DK
V
K
N
E
-----
-
R
YGV
AP
--
S
VAFGL
G
TANRLY
L
N
Y
LHV
TQ
HNTP
D
GGIPTIGLPGYSAPS
AG
T
AA
LN
HS
G
K
V
D
T
HNF
Y
GT
--
-
---
D
SD
Y
D
D
S
T
T
D
T
ATMRF
EH
DINDNTTIRNT
TR
W
SR
VK
QD
YLMT
A
IM
G
-----
G
ASNITQPT
S
-------
D
V
N
S
W
T
W
S
RTA
NT
K
D
VSNKI
L
T
--
NQT
NLTS
TF
YT
GS
IG
HDV
S
T
G
V
E
FTR
E
T
Q
TNYGV
N
PVT
L
PAV
N
I
YHP
DSS
I
HP
G
GL
T
R
NG
------------------
A
N
A
N
GQ
TD
TFA
I
YA
FD
T
LQ
I
T
R
D
F
E
L
N
GG
I
R
L
D
-
-
-----
NYH
TEYDSATAC
G
G
S
G
RGAI
T
CPA
G
M
A
KG
SPVTTVDTAKSGNLVN
W
KA
G
ALY
H
LT
E
N
GN
V
YI
N
YA
VSQQ
P
P
G
G
N
NF
A
LA
Q
S
G
SGNSANRT
DFK
PQ
K
ANT
S
EIGT
KWQ
VL
D
K
R
L
L
LT
A
A
L
FR
T
D
IE
N
EV
E
-
-
-
-
--
-
QN
DD
GT
----
Y
S
Q
Y
GK
K
R
VEG
Y
E
I
S
VAGNIT
P
----
--A
W
QV
I
G
G
Y
---
T
Q
Q
K
A
T
IKNG
K
D
VAQDG
S
S
S
LP
YT
PE
H
AFT
L
WSQY
QA
TD
D
I
S
V
G
AGA
R
Y
I
G
S--
-
---
-
M
H
KG
SDGAV
G
TPAFTE
G
-
Y
WVA
D
A
K
LG
Y
R
V
N
R
NL
D
FQLN
V
Y
NLFD
-
-
-
------
-
-
-
-
---
-
T
D
YVA
SI
N
KSG
Y
R
Y
H
PG
EP
RT
FL
L
TA
N
M
HF
fig|585035.6.peg.824
Escherichia coli S88 (10-760/760)
RQF
HSLT
FFAG
L
-
CI
G
IT
-
P
V
A
Q
A
LA
A
E
GQANA
DDTLVV
E
A
-
S
T
P
SL
-
Y
AP
QQ
S
ADP
KFSRPVADTTRTM
TV
I
S
EQVI
KD
Q
GAT
NLT
D
AL
K
N
V
P
A
V
G
A
FFA
GE
N
GNST
T
G
D
-----
A
I
Y
M
RG
ADTS
N
S-
------
IYIDG
-
-
IR
D
I
G
SV
----
--S
RDT
FN
---------
T
E
Q
VEV
IK
GP
S
GT
D
YG
R
SA
P
T
G
S
IN
M
I
S
KQP
RN---
-
--
D
S
G
I
D
A
SA
S
IGSAWFR
R
GT
L
D
V
N
QV
I
-
GD
TTAV
RL
NV
MGE
--
KT
H
D
-
---
--
-
--
-
-----
---------
AGR
DK
V
K
N
E
-----
-
R
YGV
AP
--
S
VAFGL
G
TANRLY
L
N
Y
LHV
TQ
HNTP
D
GGIPTIGLPGYSAPS
AG
T
AA
LN
HS
G
K
V
D
T
HNF
Y
GT
--
-
---
D
SD
Y
D
D
S
T
T
D
T
ATMRF
EH
DINDNTTIRNT
TR
W
SR
VK
QD
YLMT
A
IM
G
-----
G
ASNITQPT
S
-------
D
V
N
S
W
T
W
S
RTA
NT
K
D
VSNKI
L
T
--
NQT
NLTS
TF
YT
G
A
IG
HDV
S
T
G
V
E
FTR
E
T
Q
TNYGV
N
PVT
L
PAV
N
I
YHP
DSS
I
HP
G
GL
T
R
NG
------------------
A
N
A
N
GQ
TD
TFA
I
YA
FD
T
LQ
I
T
R
D
F
E
L
N
GG
I
R
L
D
-
-
-----
NYH
TEYDSATAC
G
G
S
G
RGAI
T
CPA
G
V
A
KG
SPVTTVDTAKSGNLVN
W
KA
G
ALY
H
LT
E
N
GN
I
YI
N
YA
VSQQ
P
P
G
G
N
NF
A
LA
Q
S
G
SGNSANRT
DFK
PQ
K
ANT
S
EIGT
KWQ
VL
D
K
R
L
L
LT
A
A
L
FR
T
D
IE
N
EV
E
-
-
-
-
--
-
QN
DD
GT
----
Y
S
Q
Y
GK
K
R
VEG
Y
E
I
S
VAGNIT
P
----
--A
W
QM
I
G
G
Y
---
T
Q
Q
K
A
T
IKNG
K
D
VAQDG
S
S
S
LP
YT
PE
H
AFT
L
WSQY
QA
TD
D
I
S
V
G
AGA
R
Y
I
G
S--
-
---
-
M
H
KG
SDGAV
G
TPAFTE
G
-
Y
WVA
D
A
K
LG
Y
R
V
N
R
NL
D
FQLN
V
Y
NLFD
-
-
-
------
-
-
-
-
---
-
T
D
YVA
SI
N
KSG
Y
R
Y
H
PG
EP
RT
FL
L
TA
N
M
HF
fig|431946.3.peg.766
Escherichia coli SE15 (10-760/760)
RQF
HSLT
FFAG
L
-
CI
G
IT
-
P
V
A
Q
A
LA
A
E
GQANA
DDTLVV
E
A
-
S
T
P
SL
-
Y
AP
QK
S
ADP
KFSRPVADTTRTM
TV
I
S
EQVI
KD
Q
GAT
NLT
D
AL
K
N
V
PGV
G
A
FFA
GE
N
GNST
T
G
D
-----
A
I
Y
M
RG
ADTS
N
S-
------
IYIDG
-
-
IR
D
I
G
SV
----
--S
RDT
FN
---------
T
E
Q
VEV
IK
GP
S
GT
D
YG
R
SA
P
T
G
S
IN
M
I
S
KQP
RN---
-
--
D
S
G
I
D
A
SA
S
IGSAWFR
R
GT
L
D
V
N
QV
I
-
GD
TTAV
RL
NV
MGE
--
KT
H
D
-
---
--
-
--
-
-----
---------
AGR
DK
V
K
N
E
-----
-
R
YGV
AP
--
S
VAFGL
G
TANRLY
L
N
Y
LHV
TQ
HNTP
D
GGIPTIGLPG
F
SAPS
AG
T
AA
LN
HS
G
K
V
D
T
HNF
Y
GT
--
-
---
D
SD
Y
D
D
S
T
T
D
T
ATMRF
EH
DINDNTTIRNT
TR
W
SR
VK
QD
YLMT
A
IM
G
-----
G
ASNITQPT
S
-------
D
V
N
S
W
T
W
S
RTA
NT
K
D
VSNKI
L
T
--
NQT
NLTS
TF
YT
G
A
IG
HDV
S
T
G
V
E
FTR
E
T
Q
TNYGV
N
PVT
L
PTV
N
I
YHP
DSS
I
HP
G
GL
T
R
NG
------------------
A
N
A
N
GQ
TD
TFA
I
YA
FD
T
LQ
I
T
R
D
F
E
L
N
GG
I
R
L
D
-
-
-----
NYH
TEYDSATAC
G
G
S
G
RGAI
T
CPA
G
V
A
KG
SPVTTVDTAKSGNLVN
W
KA
G
ALY
H
LT
E
N
GN
V
YI
N
YA
VSQQ
P
P
G
G
N
NF
A
LA
Q
S
G
SGNSANRT
DFK
PQ
K
ANT
S
EIGT
KWQ
VL
D
K
R
L
L
LT
A
A
L
FR
T
D
IE
N
EV
E
-
-
-
-
--
-
QN
DD
GT
----
Y
S
Q
Y
GK
K
R
VEG
Y
E
I
S
VAGNIT
P
----
--A
W
QM
I
G
G
Y
---
T
Q
Q
K
A
T
IKNG
K
D
VAQDG
S
S
S
LP
YT
PE
H
AFT
L
WSQY
QA
TD
D
I
S
V
G
AGA
R
Y
I
G
S--
-
---
-
M
H
KG
SDGAV
G
TPAFTE
G
-
Y
WVA
D
A
K
LG
Y
R
V
N
R
NL
D
FQLN
V
Y
NLFD
-
-
-
------
-
-
-
-
---
-
T
D
YVA
SI
N
KSG
Y
R
Y
H
PG
EP
RT
FL
L
TA
N
M
HF
fig|216593.1.peg.1400
Escherichia coli E2348/69 (10-760/760)
RQF
HSLT
FFAG
L
-
CI
G
IT
-
P
V
A
Q
A
LA
A
E
GQANA
DDTLVV
E
A
-
S
T
P
SL
-
Y
AP
QK
S
ADP
KFSRPVADTTRTM
TV
I
S
EQVI
KD
Q
GAT
NLT
D
AL
K
N
V
PGV
G
A
FFA
GE
N
GNST
T
G
D
-----
A
I
Y
M
RG
ADTS
N
S-
------
IYIDG
-
-
IR
D
I
G
SV
----
--S
RDT
FN
---------
T
E
Q
VEV
IK
GP
S
GT
D
YG
R
SA
P
T
G
S
IN
M
I
S
KQP
RN---
-
--
D
S
G
I
D
A
SA
S
IGSAWFR
R
GT
L
D
V
N
QV
I
-
GD
TTAV
RL
NV
MGE
--
KT
H
D
-
---
--
-
--
-
-----
---------
AGR
NK
V
K
N
E
-----
-
R
YGV
AP
--
S
VAFGL
G
TANRLY
L
N
Y
LHV
TQ
HNTP
D
GGIPTIGLPGYSAPS
AG
T
AA
LN
HS
G
K
V
D
T
HNF
Y
GT
--
-
---
D
SD
Y
D
D
S
T
T
D
T
ATMRF
EH
DINDNTTIRNT
TR
W
SR
VK
QD
YLMT
A
IM
G
-----
G
ASNITQPT
S
-------
D
V
N
S
W
T
W
S
RTA
NT
K
D
VSNKI
L
T
--
NQT
NLTS
TF
YT
G
A
IG
HDV
S
T
G
V
E
FTR
E
T
Q
TNYGV
N
PVT
L
PAV
N
I
YHP
DSS
I
HP
G
GL
T
R
NG
------------------
A
N
A
N
GQ
TD
TFA
I
YA
FD
T
LQ
I
T
R
D
F
E
L
N
GG
I
R
L
D
-
-
-----
NYH
TEYDSATAC
G
G
S
G
RGAI
T
CPA
S
V
A
KG
SPVTTVDTAKSGNLVN
W
KA
G
ALY
H
LT
E
N
GN
V
YI
N
YA
VSQQ
P
P
G
G
N
NF
A
LA
Q
S
G
SGNSANRT
DFK
PQ
K
ANT
S
EIGT
KWQ
VL
D
K
R
L
L
LT
A
A
L
FR
T
D
IE
N
EV
E
-
-
-
-
--
-
QN
DD
GT
----
Y
S
Q
Y
GK
K
R
VEG
Y
E
I
S
VAGNIT
P
----
--A
W
QM
I
G
G
Y
---
T
Q
Q
K
A
T
IKNG
K
D
VAQDG
S
S
S
LP
YT
PE
H
AFT
L
WSQY
QA
TD
D
I
S
V
G
AGA
R
Y
I
G
S--
-
---
-
M
H
KG
SDGAV
G
TPAFTE
G
-
Y
WVA
D
A
K
LG
Y
R
V
N
R
NL
D
FQLN
V
Y
NLFD
-
-
-
------
-
-
-
-
---
-
T
D
YVA
SI
N
KSG
Y
R
Y
H
PG
EP
RT
FL
L
TA
N
M
HF
fig|869729.3.peg.1535
Escherichia coli UM146 (19-668/673)
I
A
N
A
QT
S
Q
---QD
ES
TLVVTA
-
S
K
QS
SR
S
A
S
AN
N
VSS
-------------
TV
V
S
APEL
S
D
A
G
V
T
ASD
K
LP
R
V
L
PG
L
N
I
---
EN
S
GN
ML
F
S
T
-----
-
I
S
L
RG
VSSA
Q
DF
YNPAVTL
Y
V
DG
V
P
QL
S
T
N
TI
----
QAL
T
D
-
--
---------
V
Q
S
VE
L
LRGP
Q
GT
L
YG
K
SA
Q
GG
I
INI
V
T
Q
QP
DSTPR
G
YI
E
G
G
V
S
S
RD
S
Y------
R
SK
F
N
L
S
GPI
-
Q
D
GL--
-
LYG
SVT
LLRQ
V
DD
GDM
IN
P
AT
G
SDDLG
---------
GT
R
AS
I
G
N
-
-----
V
K
LRL
AP
--
-
-----
-
------
-
-
-
---
--
----
D
---------------
--
-
--
--
--
-
-
-
-
-
---
-
--
--
-
---
D
QP
W
E
M
G
F
A
A
S
-----
--
-----------
RE
C
T
R
AT
QD
----
A
YV
G
WNDIK
G
RKLSISDG
S
PDPYMRR
C
T
DS
Q
TLS
GKY
T
T
D
D
WVFNL
I
S
AWQ
Q
Q
HYSR
TF
PS
GS
LI
--
V
N
M
S
Q
R
WNQ
D
V
Q
ELRAA
T
LGD
A
RTV
D
M
---
---
V
--
F
GL
Y
R
QN
TREKLNSAYDMPTMPYLS
S
T
G
Y
TT
AET
L
A
A
Y
S
DL
T
WH
LTD
R
F
D
I
G
GG
V
RF
S
-
H
DKSST
Q
YH
GSM-LGNPF
GD
Q
G
KSND
D
QVL
G
-
-
--
----------------
-
QL
S
A
G
Y
M
LT
D
D
WR
V
Y
T
R
V
A
QGYK
P
S
G
Y
N
IV
P
--
T
AG
----LDAK
P
F
V
AEKSIN
Y
E
L
GT
R
YE
TA
D
V
-
T
L
QA
AT
F
YT
H
T
KD
M
QL
Y
S
G
P
V
GM
-
Q
T
--
--
----
L
SN
A
GKA
D
AT
G
V
E
L
E
AKWRFA
P
----
GWS
W
DI
NG
N
V
---
I
R
S
E
F
T
----
N
D
SELYH
G
N
R
V
P
FV
P
R
Y
GAG
S
SVN-
--
--
-
-
-
-
G
VID
T
R
YG
ALM
P
RLA
V
N
L
V
G
PHYFD
G
DNQLRQ
G
T
Y
ATL
D
S
SLGW
Q
A
T
E
R
MN
ISVY
VDNLFD
R
R
Y
------
R
T
Y
G
YMN
G
SS
A
VA
QV
N
M--
-
-
-
-
-
G
--
RT
--
V
GI
NT
fig|364106.7.peg.2222
Escherichia coli UTI89 (19-668/673)
I
A
N
A
QT
S
Q
---QD
ES
TLVVTA
-
S
K
QS
SR
S
A
S
AN
N
VSS
-------------
TV
V
S
APEL
S
D
A
G
V
T
ASD
K
LP
R
V
L
PG
L
N
I
---
EN
S
GN
ML
F
S
T
-----
-
I
S
L
RG
VSSA
Q
DF
YNPAVTL
Y
V
DG
V
P
QL
S
T
N
TI
----
QAL
T
D
-
--
---------
V
Q
S
VE
L
LRGP
Q
GT
L
YG
K
SA
Q
GG
I
INI
V
T
Q
QP
DSTPR
G
YI
E
G
G
V
S
S
RD
S
Y------
R
SK
F
N
L
S
GPI
-
Q
D
GL--
-
LYG
SVT
LLRQ
V
DD
GDM
IN
P
AT
G
SDDLG
---------
GT
R
AS
I
G
N
-
-----
V
K
LRL
AP
--
-
-----
-
------
-
-
-
---
--
----
D
---------------
--
-
--
--
--
-
-
-
-
-
---
-
--
--
-
---
D
QP
W
E
M
G
F
A
A
S
-----
--
-----------
RE
C
T
R
AT
QD
----
A
YV
G
WNDIK
G
RKLSISDG
S
PDPYMRR
C
T
DS
Q
TLS
GKY
T
T
D
D
WVFNL
I
S
AWQ
Q
Q
HYSR
TF
PS
GS
LI
--
V
N
M
S
Q
R
WNQ
D
V
Q
ELRAA
T
LGD
A
RTV
D
M
---
---
V
--
F
GL
Y
R
QN
TREKLNSAYDMPTMPYLS
S
T
G
Y
TT
AET
L
A
A
Y
S
DL
T
WH
LTD
R
F
D
I
G
GG
V
RF
S
-
H
DKSST
Q
YH
GSM-LGNPF
GD
Q
G
KSND
D
QVL
G
-
-
--
----------------
-
QL
S
A
G
Y
M
LT
D
D
WR
V
Y
T
R
V
A
QGYK
P
S
G
Y
N
IV
P
--
T
AG
----LDAK
P
F
V
AEKSIN
Y
E
L
GT
R
YE
TA
D
V
-
T
L
QA
AT
F
YT
H
T
KD
M
QL
Y
S
G
P
V
GM
-
Q
T
--
--
----
L
SN
A
GKA
D
AT
G
V
E
L
E
AKWRFA
P
----
GWS
W
DI
NG
N
V
---
I
R
S
E
F
T
----
N
D
SELYH
G
N
R
V
P
FV
P
R
Y
GAG
S
SVN-
--
--
-
-
-
-
G
VID
T
R
YG
ALM
P
RLA
V
N
L
V
G
PHYFD
G
DNQLRQ
G
T
Y
ATL
D
S
SLGW
Q
A
T
E
R
MN
ISVY
VDNLFD
R
R
Y
------
R
T
Y
G
YMN
G
SS
A
VA
QV
N
M--
-
-
-
-
-
G
--
RT
--
V
GI
NT
fig|364106.8.peg.2223
Escherichia coli UTI89 (19-668/673)
I
A
N
A
QT
S
Q
---QD
ES
TLVVTA
-
S
K
QS
SR
S
A
S
AN
N
VSS
-------------
TV
V
S
APEL
S
D
A
G
V
T
ASD
K
LP
R
V
L
PG
L
N
I
---
EN
S
GN
ML
F
S
T
-----
-
I
S
L
RG
VSSA
Q
DF
YNPAVTL
Y
V
DG
V
P
QL
S
T
N
TI
----
QAL
T
D
-
--
---------
V
Q
S
VE
L
LRGP
Q
GT
L
YG
K
SA
Q
GG
I
INI
V
T
Q
QP
DSTPR
G
YI
E
G
G
V
S
S
RD
S
Y------
R
SK
F
N
L
S
GPI
-
Q
D
GL--
-
LYG
SVT
LLRQ
V
DD
GDM
IN
P
AT
G
SDDLG
---------
GT
R
AS
I
G
N
-
-----
V
K
LRL
AP
--
-
-----
-
------
-
-
-
---
--
----
D
---------------
--
-
--
--
--
-
-
-
-
-
---
-
--
--
-
---
D
QP
W
E
M
G
F
A
A
S
-----
--
-----------
RE
C
T
R
AT
QD
----
A
YV
G
WNDIK
G
RKLSISDG
S
PDPYMRR
C
T
DS
Q
TLS
GKY
T
T
D
D
WVFNL
I
S
AWQ
Q
Q
HYSR
TF
PS
GS
LI
--
V
N
M
S
Q
R
WNQ
D
V
Q
ELRAA
T
LGD
A
RTV
D
M
---
---
V
--
F
GL
Y
R
QN
TREKLNSAYDMPTMPYLS
S
T
G
Y
TT
AET
L
A
A
Y
S
DL
T
WH
LTD
R
F
D
I
G
GG
V
RF
S
-
H
DKSST
Q
YH
GSM-LGNPF
GD
Q
G
KSND
D
QVL
G
-
-
--
----------------
-
QL
S
A
G
Y
M
LT
D
D
WR
V
Y
T
R
V
A
QGYK
P
S
G
Y
N
IV
P
--
T
AG
----LDAK
P
F
V
AEKSIN
Y
E
L
GT
R
YE
TA
D
V
-
T
L
QA
AT
F
YT
H
T
KD
M
QL
Y
S
G
P
V
GM
-
Q
T
--
--
----
L
SN
A
GKA
D
AT
G
V
E
L
E
AKWRFA
P
----
GWS
W
DI
NG
N
V
---
I
R
S
E
F
T
----
N
D
SELYH
G
N
R
V
P
FV
P
R
Y
GAG
S
SVN-
--
--
-
-
-
-
G
VID
T
R
YG
ALM
P
RLA
V
N
L
V
G
PHYFD
G
DNQLRQ
G
T
Y
ATL
D
S
SLGW
Q
A
T
E
R
MN
ISVY
VDNLFD
R
R
Y
------
R
T
Y
G
YMN
G
SS
A
VA
QV
N
M--
-
-
-
-
-
G
--
RT
--
V
GI
NT
fig|1040638.4.peg.3523
Escherichia coli O104:H4 str. LB226692 (19-668/673)
I
A
N
A
QT
S
Q
---QD
ES
TLVVTA
-
S
K
QS
SR
S
A
S
AN
N
VSS
-------------
TV
V
S
APEL
S
D
A
G
V
T
ASD
K
LP
R
V
L
PG
L
N
I
---
EN
S
GN
ML
F
S
T
-----
-
I
S
L
RG
VSSA
Q
DF
YNPAVTL
Y
V
DG
V
P
QL
S
T
N
TI
----
QAL
T
D
-
--
---------
V
Q
S
VE
L
LRGP
Q
GT
L
YG
K
SA
Q
GG
I
INI
V
T
Q
QP
DSTPR
G
YI
E
G
G
V
S
S
SD
S
Y------
R
SK
F
N
L
S
GPI
-
E
D
GL--
-
LYG
SVT
LLRQ
V
DD
GDM
IN
P
AT
G
SDDLG
---------
GT
R
AS
I
G
N
-
-----
V
K
LRL
AP
--
-
-----
-
------
-
-
-
---
--
----
D
---------------
--
-
--
--
--
-
-
-
-
-
---
-
--
--
-
---
D
QP
W
E
M
G
F
A
A
S
-----
--
-----------
RE
C
T
R
AT
QD
----
A
YV
G
WNDIK
G
RKLSISDG
S
PDPYMRR
C
T
DS
Q
TLS
GKY
T
T
D
D
WVFNL
I
S
AWQ
Q
Q
HYSR
TF
PS
GS
LI
--
V
N
M
P
Q
R
WNQ
D
V
Q
ELRAA
T
LGD
A
RTV
D
M
---
---
V
--
F
GL
Y
R
QN
TREKLNSAYDMPTMPYLS
S
T
G
Y
TT
AET
L
A
A
Y
S
DL
T
WH
LTD
R
F
D
I
G
GG
V
RF
S
-
H
DKSST
Q
YH
GSM-LGNPF
GD
Q
G
KSND
D
QVL
G
-
-
--
----------------
-
QL
S
A
G
Y
M
LT
D
D
WR
V
Y
T
R
V
A
QGYK
P
S
G
Y
N
IV
P
--
T
AG
----LDAK
P
F
V
AEKSIN
Y
E
L
GT
R
YE
TA
D
V
-
T
L
QA
AT
F
YT
H
T
KD
M
QL
Y
S
G
P
V
GM
-
Q
T
--
--
----
L
SN
A
GKA
D
AT
G
V
E
L
E
AKWRFA
P
----
GWS
W
DI
NG
N
V
---
I
R
S
E
F
T
----
N
D
SELYH
G
N
R
V
P
FV
P
R
Y
GAG
S
SVN-
--
--
-
-
-
-
G
VID
T
R
YG
ALM
P
RLA
V
N
L
V
G
PHYFD
G
DNQLRQ
G
T
Y
ATL
D
S
SLGW
Q
A
T
E
R
MN
ISVY
VDNLFD
R
R
Y
------
R
T
Y
G
YMN
G
SS
A
VA
QV
N
M--
-
-
-
-
-
G
--
RT
--
V
GI
NT
fig|6666666.5357.peg.4207
Escherichia coli TY-2482 (19-668/673)
I
A
N
A
QT
S
Q
---QD
ES
TLVVTA
-
S
K
QS
SR
S
A
S
AN
N
VSS
-------------
TV
V
S
APEL
S
D
A
G
V
T
ASD
K
LP
R
V
L
PG
L
N
I
---
EN
S
GN
ML
F
S
T
-----
-
I
S
L
RG
VSSA
Q
DF
YNPAVTL
Y
V
DG
V
P
QL
S
T
N
TI
----
QAL
T
D
-
--
---------
V
Q
S
VE
L
LRGP
Q
GT
L
YG
K
SA
Q
GG
I
INI
V
T
Q
QP
DSTPR
G
YI
E
G
G
V
S
S
SD
S
Y------
R
SK
F
N
L
S
GPI
-
E
D
GL--
-
LYG
SVT
LLRQ
V
DD
GDM
IN
P
AT
G
SDDLG
---------
GT
R
AS
I
G
N
-
-----
V
K
LRL
AP
--
-
-----
-
------
-
-
-
---
--
----
D
---------------
--
-
--
--
--
-
-
-
-
-
---
-
--
--
-
---
D
QP
W
E
M
G
F
A
A
S
-----
--
-----------
RE
C
T
R
AT
QD
----
A
YV
G
WNDIK
G
RKLSISDG
S
PDPYMRR
C
T
DS
Q
TLS
GKY
T
T
D
D
WVFNL
I
S
AWQ
Q
Q
HYSR
TF
PS
GS
LI
--
V
N
M
P
Q
R
WNQ
D
V
Q
ELRAA
T
LGD
A
RTV
D
M
---
---
V
--
F
GL
Y
R
QN
TREKLNSAYDMPTMPYLS
S
T
G
Y
TT
AET
L
A
A
Y
S
DL
T
WH
LTD
R
F
D
I
G
GG
V
RF
S
-
H
DKSST
Q
YH
GSM-LGNPF
GD
Q
G
KSND
D
QVL
G
-
-
--
----------------
-
QL
S
A
G
Y
M
LT
D
D
WR
V
Y
T
R
V
A
QGYK
P
S
G
Y
N
IV
P
--
T
AG
----LDAK
P
F
V
AEKSIN
Y
E
L
GT
R
YE
TA
D
V
-
T
L
QA
AT
F
YT
H
T
KD
M
QL
Y
S
G
P
V
GM
-
Q
T
--
--
----
L
SN
A
GKA
D
AT
G
V
E
L
E
AKWRFA
P
----
GWS
W
DI
NG
N
V
---
I
R
S
E
F
T
----
N
D
SELYH
G
N
R
V
P
FV
P
R
Y
GAG
S
SVN-
--
--
-
-
-
-
G
VID
T
R
YG
ALM
P
RLA
V
N
L
V
G
PHYFD
G
DNQLRQ
G
T
Y
ATL
D
S
SLGW
Q
A
T
E
R
MN
ISVY
VDNLFD
R
R
Y
------
R
T
Y
G
YMN
G
SS
A
VA
QV
N
M--
-
-
-
-
-
G
--
RT
--
V
GI
NT
fig|585055.6.peg.2245
Escherichia coli 55989 (19-668/673)
I
A
N
A
QT
S
Q
---QD
ES
TLVVTA
-
S
K
QS
SR
S
A
S
AN
N
VSS
-------------
TV
V
S
APEL
S
D
A
G
V
T
ASD
K
LP
R
V
L
PG
L
N
I
---
EN
S
GN
ML
F
S
T
-----
-
I
S
L
RG
VSSA
Q
DF
YNPAVTL
Y
V
DG
V
P
QL
S
T
N
TI
----
QAL
T
D
-
--
---------
V
Q
S
VE
L
LRGP
Q
GT
L
YG
K
SA
Q
GG
I
INI
V
T
Q
QP
DSTPR
G
YI
E
G
G
V
S
S
SD
S
Y------
R
SK
F
N
L
S
GPI
-
E
D
GL--
-
LYG
SVT
LLRQ
V
DD
GDM
IN
P
AT
G
SDDLG
---------
GT
R
AS
I
G
N
-
-----
V
K
LRL
AP
--
-
-----
-
------
-
-
-
---
--
----
D
---------------
--
-
--
--
--
-
-
-
-
-
---
-
--
--
-
---
D
QP
W
E
M
G
F
A
A
S
-----
--
-----------
RE
C
T
R
AT
QD
----
A
YV
G
WNDIK
G
RKLSISDG
S
PDPYMRR
C
T
DS
Q
TLS
GKY
T
T
D
D
WVFNL
I
S
AWQ
Q
Q
HYSR
TF
PS
GS
LI
--
V
N
M
P
Q
R
WNQ
D
V
Q
ELRAA
T
LGD
A
RTV
D
M
---
---
V
--
F
GL
Y
R
QN
TREKLNSAYDMPTMPYLS
S
T
G
Y
TT
AET
L
A
A
Y
S
DL
T
WH
LTD
R
F
D
I
G
GG
V
RF
S
-
H
DKSST
Q
YH
GSM-LGNPF
GD
Q
G
KSND
D
QVL
G
-
-
--
----------------
-
QL
S
A
G
Y
M
LT
D
D
WR
V
Y
T
R
V
A
QGYK
P
S
G
Y
N
IV
P
--
T
AG
----LDAK
P
F
V
AEKSIN
Y
E
L
GT
R
YE
TA
D
V
-
T
L
QA
AT
F
YT
H
T
KD
M
QL
Y
S
G
P
V
GM
-
Q
T
--
--
----
L
SN
A
GKA
D
AT
G
V
E
L
E
AKWRFA
P
----
GWS
W
DI
NG
N
V
---
I
R
S
E
F
T
----
N
D
SELYH
G
N
R
V
P
FV
P
R
Y
GAG
S
SVN-
--
--
-
-
-
-
G
VID
T
R
YG
ALM
P
RLA
V
N
L
V
G
PHYFD
G
DNQLRQ
G
T
Y
ATL
D
S
SLGW
Q
A
T
E
R
MN
ISVY
VDNLFD
R
R
Y
------
R
T
Y
G
YMN
G
SS
A
VA
QV
N
M--
-
-
-
-
-
G
--
RT
--
V
GI
NT
fig|585055.8.peg.2250
Escherichia coli 55989 (19-668/673)
I
A
N
A
QT
S
Q
---QD
ES
TLVVTA
-
S
K
QS
SR
S
A
S
AN
N
VSS
-------------
TV
V
S
APEL
S
D
A
G
V
T
ASD
K
LP
R
V
L
PG
L
N
I
---
EN
S
GN
ML
F
S
T
-----
-
I
S
L
RG
VSSA
Q
DF
YNPAVTL
Y
V
DG
V
P
QL
S
T
N
TI
----
QAL
T
D
-
--
---------
V
Q
S
VE
L
LRGP
Q
GT
L
YG
K
SA
Q
GG
I
INI
V
T
Q
QP
DSTPR
G
YI
E
G
G
V
S
S
SD
S
Y------
R
SK
F
N
L
S
GPI
-
E
D
GL--
-
LYG
SVT
LLRQ
V
DD
GDM
IN
P
AT
G
SDDLG
---------
GT
R
AS
I
G
N
-
-----
V
K
LRL
AP
--
-
-----
-
------
-
-
-
---
--
----
D
---------------
--
-
--
--
--
-
-
-
-
-
---
-
--
--
-
---
D
QP
W
E
M
G
F
A
A
S
-----
--
-----------
RE
C
T
R
AT
QD
----
A
YV
G
WNDIK
G
RKLSISDG
S
PDPYMRR
C
T
DS
Q
TLS
GKY
T
T
D
D
WVFNL
I
S
AWQ
Q
Q
HYSR
TF
PS
GS
LI
--
V
N
M
P
Q
R
WNQ
D
V
Q
ELRAA
T
LGD
A
RTV
D
M
---
---
V
--
F
GL
Y
R
QN
TREKLNSAYDMPTMPYLS
S
T
G
Y
TT
AET
L
A
A
Y
S
DL
T
WH
LTD
R
F
D
I
G
GG
V
RF
S
-
H
DKSST
Q
YH
GSM-LGNPF
GD
Q
G
KSND
D
QVL
G
-
-
--
----------------
-
QL
S
A
G
Y
M
LT
D
D
WR
V
Y
T
R
V
A
QGYK
P
S
G
Y
N
IV
P
--
T
AG
----LDAK
P
F
V
AEKSIN
Y
E
L
GT
R
YE
TA
D
V
-
T
L
QA
AT
F
YT
H
T
KD
M
QL
Y
S
G
P
V
GM
-
Q
T
--
--
----
L
SN
A
GKA
D
AT
G
V
E
L
E
AKWRFA
P
----
GWS
W
DI
NG
N
V
---
I
R
S
E
F
T
----
N
D
SELYH
G
N
R
V
P
FV
P
R
Y
GAG
S
SVN-
--
--
-
-
-
-
G
VID
T
R
YG
ALM
P
RLA
V
N
L
V
G
PHYFD
G
DNQLRQ
G
T
Y
ATL
D
S
SLGW
Q
A
T
E
R
MN
ISVY
VDNLFD
R
R
Y
------
R
T
Y
G
YMN
G
SS
A
VA
QV
N
M--
-
-
-
-
-
G
--
RT
--
V
GI
NT
fig|749545.3.peg.1934
Escherichia coli MS 182-1 (19-668/673)
I
A
N
A
QT
S
Q
---QD
ES
TLVVTA
-
S
K
QS
SR
S
A
S
AN
N
VSS
-------------
TV
V
S
APEL
S
D
A
G
V
T
ASD
K
LP
R
V
L
PG
L
N
I
---
EN
S
GN
ML
F
S
T
-----
-
I
S
L
RG
VSSA
Q
DF
YNPAVTL
Y
V
DG
V
P
QL
S
T
N
TI
----
QAL
T
D
-
--
---------
V
Q
S
VE
L
LRGP
Q
GT
L
YG
K
SA
Q
GG
I
INI
V
T
Q
QP
DSTPR
G
YI
E
G
G
V
S
S
RD
S
Y------
R
SK
F
N
L
S
GPI
-
Q
D
GL--
-
LYG
SVT
LLRQ
V
DD
GDM
IN
P
AT
G
SDDLG
---------
GT
R
AS
I
G
N
-
-----
V
K
LRL
AP
--
-
-----
-
------
-
-
-
---
--
----
D
---------------
--
-
--
--
--
-
-
-
-
-
---
-
--
--
-
---
D
QP
W
E
M
G
F
A
A
S
-----
--
-----------
RE
C
T
R
AT
QD
----
A
YV
G
WNDIK
G
RKLSISDG
S
PDPYMRR
C
T
DS
Q
TLS
GKY
T
T
D
D
WVFNL
I
S
AWQ
Q
Q
HYSR
TF
PS
GS
LI
--
V
N
M
P
Q
R
WNQ
N
V
Q
ELRAA
T
LGD
A
RTV
D
M
---
---
V
--
F
GL
Y
R
QN
TREKLNSAYDMPTMPYLS
S
T
G
Y
TT
AET
L
A
A
Y
S
DL
T
WH
LTD
R
F
D
I
G
GG
V
RF
S
-
H
DKSST
Q
YH
GSM-LGNPF
GD
Q
G
KSND
D
QVL
G
-
-
--
----------------
-
QL
S
A
G
Y
M
LT
D
D
WR
V
Y
T
R
V
A
QGYK
P
S
G
Y
N
IV
P
--
T
AG
----LDAK
P
F
V
AEKSIN
Y
E
L
GT
R
YE
TA
D
V
-
T
L
QA
AT
F
YT
H
T
KD
M
QL
Y
S
G
P
V
GM
-
Q
T
--
--
----
L
SN
A
GKA
D
AT
G
V
E
L
E
AKWRFA
P
----
GWS
W
DI
NG
N
V
---
I
R
S
E
F
T
----
N
D
SELYH
G
N
R
V
P
FV
P
R
Y
GAG
S
SVN-
--
--
-
-
-
-
G
VID
T
R
YG
ALM
P
RLA
V
N
L
V
G
PHYFD
G
DNQLRQ
G
T
Y
ATL
D
S
SLGW
Q
A
T
E
R
MN
ISVY
VDNLFD
R
R
Y
------
R
T
Y
G
YMN
G
SS
A
VA
QV
N
M--
-
-
-
-
-
G
--
RT
--
V
GI
NT
fig|362663.8.peg.1973
Escherichia coli 536 (19-668/673)
I
A
N
A
QT
S
Q
---QD
ES
TLVVTA
-
S
K
QS
SR
S
A
S
AN
N
VSS
-------------
TV
V
S
APEL
S
D
A
G
V
T
ASD
K
LP
R
V
L
PG
L
N
I
---
EN
S
GN
ML
F
S
T
-----
-
I
S
L
RG
VSSA
Q
DF
YNPAVTL
Y
V
DG
V
P
QL
S
T
N
TI
----
QAL
T
D
-
--
---------
V
Q
S
VE
L
LRGP
Q
GT
L
YG
K
SA
Q
GG
I
INI
V
T
Q
QP
DSTPR
G
YI
E
G
G
V
S
S
RD
S
Y------
R
SK
F
N
L
S
GPI
-
Q
D
GL--
-
LYG
SVT
LLRQ
V
DD
GDM
IN
P
AT
G
SDDLG
---------
GT
R
AS
I
G
N
-
-----
V
K
LRL
AP
--
-
-----
-
------
-
-
-
---
--
----
D
---------------
--
-
--
--
--
-
-
-
-
-
---
-
--
--
-
---
D
QP
W
E
M
G
F
A
A
S
-----
--
-----------
RE
C
T
R
AT
QD
----
A
YV
G
WNDIK
G
RKLSISDG
S
PDPYMRR
C
T
DS
Q
TLS
GKY
T
T
D
D
WVFNL
I
S
AWQ
Q
Q
HYSR
TF
PS
GS
LI
--
V
N
M
P
Q
R
WNQ
D
V
Q
ELRAA
T
LGD
A
RTV
D
M
---
---
V
--
F
GL
Y
R
QN
TREKLNSAYDMPTMPYLS
S
T
G
Y
TT
AET
L
A
A
Y
S
DL
T
WH
LTD
R
F
D
I
G
GG
V
RF
S
-
H
DKSST
Q
YH
GSM-LGNPF
GD
Q
G
KSND
D
QVL
G
-
-
--
----------------
-
QL
S
A
G
Y
M
LT
D
D
WR
V
Y
T
R
V
A
QGYK
P
S
G
Y
N
IV
P
--
T
AG
----LDAK
P
F
V
AEKSIN
Y
E
L
GT
R
YE
TA
D
V
-
T
L
QA
AT
F
YT
H
T
KD
M
QL
Y
S
G
P
V
GM
-
Q
T
--
--
----
L
SN
A
GKA
D
AT
G
V
E
L
E
AKWRFA
P
----
GWS
W
DI
NG
N
V
---
I
R
S
E
F
T
----
N
D
SELYH
G
N
R
V
P
FV
P
R
Y
GAG
S
SVN-
--
--
-
-
-
-
G
VID
T
R
YG
ALM
P
RLA
V
N
L
V
G
PHYFD
G
DNQLRQ
G
T
Y
ATL
D
S
SLGW
Q
A
T
E
R
MN
ISVY
VDNLFD
R
R
Y
------
R
T
Y
G
YMN
G
SS
A
VA
QV
N
M--
-
-
-
-
-
G
--
RT
--
V
GI
NT
fig|362663.9.peg.1978
Escherichia coli 536 (19-668/673)
I
A
N
A
QT
S
Q
---QD
ES
TLVVTA
-
S
K
QS
SR
S
A
S
AN
N
VSS
-------------
TV
V
S
APEL
S
D
A
G
V
T
ASD
K
LP
R
V
L
PG
L
N
I
---
EN
S
GN
ML
F
S
T
-----
-
I
S
L
RG
VSSA
Q
DF
YNPAVTL
Y
V
DG
V
P
QL
S
T
N
TI
----
QAL
T
D
-
--
---------
V
Q
S
VE
L
LRGP
Q
GT
L
YG
K
SA
Q
GG
I
INI
V
T
Q
QP
DSTPR
G
YI
E
G
G
V
S
S
RD
S
Y------
R
SK
F
N
L
S
GPI
-
Q
D
GL--
-
LYG
SVT
LLRQ
V
DD
GDM
IN
P
AT
G
SDDLG
---------
GT
R
AS
I
G
N
-
-----
V
K
LRL
AP
--
-
-----
-
------
-
-
-
---
--
----
D
---------------
--
-
--
--
--
-
-
-
-
-
---
-
--
--
-
---
D
QP
W
E
M
G
F
A
A
S
-----
--
-----------
RE
C
T
R
AT
QD
----
A
YV
G
WNDIK
G
RKLSISDG
S
PDPYMRR
C
T
DS
Q
TLS
GKY
T
T
D
D
WVFNL
I
S
AWQ
Q
Q
HYSR
TF
PS
GS
LI
--
V
N
M
P
Q
R
WNQ
D
V
Q
ELRAA
T
LGD
A
RTV
D
M
---
---
V
--
F
GL
Y
R
QN
TREKLNSAYDMPTMPYLS
S
T
G
Y
TT
AET
L
A
A
Y
S
DL
T
WH
LTD
R
F
D
I
G
GG
V
RF
S
-
H
DKSST
Q
YH
GSM-LGNPF
GD
Q
G
KSND
D
QVL
G
-
-
--
----------------
-
QL
S
A
G
Y
M
LT
D
D
WR
V
Y
T
R
V
A
QGYK
P
S
G
Y
N
IV
P
--
T
AG
----LDAK
P
F
V
AEKSIN
Y
E
L
GT
R
YE
TA
D
V
-
T
L
QA
AT
F
YT
H
T
KD
M
QL
Y
S
G
P
V
GM
-
Q
T
--
--
----
L
SN
A
GKA
D
AT
G
V
E
L
E
AKWRFA
P
----
GWS
W
DI
NG
N
V
---
I
R
S
E
F
T
----
N
D
SELYH
G
N
R
V
P
FV
P
R
Y
GAG
S
SVN-
--
--
-
-
-
-
G
VID
T
R
YG
ALM
P
RLA
V
N
L
V
G
PHYFD
G
DNQLRQ
G
T
Y
ATL
D
S
SLGW
Q
A
T
E
R
MN
ISVY
VDNLFD
R
R
Y
------
R
T
Y
G
YMN
G
SS
A
VA
QV
N
M--
-
-
-
-
-
G
--
RT
--
V
GI
NT
fig|344610.3.peg.4444
Escherichia coli 53638 (19-668/673)
I
A
N
A
QT
S
Q
---QD
ES
TLVVTA
-
S
K
QS
SR
S
A
S
AN
N
VSS
-------------
TV
V
S
APEL
S
D
A
G
V
T
ASD
K
LP
R
V
L
PG
L
N
I
---
EN
S
GN
ML
F
S
T
-----
-
I
S
L
RG
VSSA
Q
DF
YNPAVTL
Y
V
DG
V
P
QL
S
T
N
TI
----
QAL
T
D
-
--
---------
V
Q
S
VE
L
LRGP
Q
GT
L
YG
K
SA
Q
GG
I
INI
V
T
Q
QP
DSTPR
G
YI
E
G
G
V
S
S
RD
S
Y------
R
SK
F
N
L
S
GPI
-
Q
D
GL--
-
LYG
SVT
LLRQ
V
DD
GDM
IN
P
AT
G
SDDLG
---------
GT
R
AS
I
G
N
-
-----
V
K
LRL
AP
--
-
-----
-
------
-
-
-
---
--
----
D
---------------
--
-
--
--
--
-
-
-
-
-
---
-
--
--
-
---
D
QP
W
E
M
G
F
A
A
S
-----
--
-----------
RE
C
T
R
AT
QD
----
A
YV
G
WNDIK
G
RKLSISDG
S
PDPYMRR
C
T
DS
Q
TLS
GKY
T
T
D
D
WVFNL
I
S
AWQ
Q
Q
HYSR
TF
PS
GS
LI
--
V
N
M
P
Q
R
WNQ
D
V
Q
ELRAA
T
LGD
A
RTV
D
M
---
---
V
--
F
GL
Y
R
QN
TREKLNSAYDMPTMPYLS
S
T
G
Y
TT
AET
L
A
A
Y
S
DL
T
WH
LTD
R
F
D
I
G
GG
V
RF
S
-
H
DKSST
Q
YH
GSM-LGNPF
GD
Q
G
KSND
D
QVL
G
-
-
--
----------------
-
QL
S
A
G
Y
M
LT
D
D
WR
V
Y
T
R
V
A
QGYK
P
S
G
Y
N
IV
P
--
T
AG
----LDAK
P
F
V
AEKSIN
Y
E
L
GT
R
YE
TA
D
V
-
T
L
QA
AT
F
YT
H
T
KD
M
QL
Y
S
G
P
V
GM
-
Q
T
--
--
----
L
SN
A
GKA
D
AT
G
V
E
L
E
AKWRFA
P
----
GWS
W
DI
NG
N
V
---
I
R
S
E
F
T
----
N
D
SELYH
G
N
R
V
P
FV
P
R
Y
GAG
S
SVN-
--
--
-
-
-
-
G
VID
T
R
YG
ALM
P
RLA
V
N
L
V
G
PHYFD
G
DNQLRQ
G
T
Y
ATL
D
S
SLGW
Q
A
T
E
R
MN
ISVY
VDNLFD
R
R
Y
------
R
T
Y
G
YMN
G
SS
A
VA
QV
N
M--
-
-
-
-
-
G
--
RT
--
V
GI
NT
fig|344610.7.peg.4527
Escherichia coli 53638 (19-668/673)
I
A
N
A
QT
S
Q
---QD
ES
TLVVTA
-
S
K
QS
SR
S
A
S
AN
N
VSS
-------------
TV
V
S
APEL
S
D
A
G
V
T
ASD
K
LP
R
V
L
PG
L
N
I
---
EN
S
GN
ML
F
S
T
-----
-
I
S
L
RG
VSSA
Q
DF
YNPAVTL
Y
V
DG
V
P
QL
S
T
N
TI
----
QAL
T
D
-
--
---------
V
Q
S
VE
L
LRGP
Q
GT
L
YG
K
SA
Q
GG
I
INI
V
T
Q
QP
DSTPR
G
YI
E
G
G
V
S
S
RD
S
Y------
R
SK
F
N
L
S
GPI
-
Q
D
GL--
-
LYG
SVT
LLRQ
V
DD
GDM
IN
P
AT
G
SDDLG
---------
GT
R
AS
I
G
N
-
-----
V
K
LRL
AP
--
-
-----
-
------
-
-
-
---
--
----
D
---------------
--
-
--
--
--
-
-
-
-
-
---
-
--
--
-
---
D
QP
W
E
M
G
F
A
A
S
-----
--
-----------
RE
C
T
R
AT
QD
----
A
YV
G
WNDIK
G
RKLSISDG
S
PDPYMRR
C
T
DS
Q
TLS
GKY
T
T
D
D
WVFNL
I
S
AWQ
Q
Q
HYSR
TF
PS
GS
LI
--
V
N
M
P
Q
R
WNQ
D
V
Q
ELRAA
T
LGD
A
RTV
D
M
---
---
V
--
F
GL
Y
R
QN
TREKLNSAYDMPTMPYLS
S
T
G
Y
TT
AET
L
A
A
Y
S
DL
T
WH
LTD
R
F
D
I
G
GG
V
RF
S
-
H
DKSST
Q
YH
GSM-LGNPF
GD
Q
G
KSND
D
QVL
G
-
-
--
----------------
-
QL
S
A
G
Y
M
LT
D
D
WR
V
Y
T
R
V
A
QGYK
P
S
G
Y
N
IV
P
--
T
AG
----LDAK
P
F
V
AEKSIN
Y
E
L
GT
R
YE
TA
D
V
-
T
L
QA
AT
F
YT
H
T
KD
M
QL
Y
S
G
P
V
GM
-
Q
T
--
--
----
L
SN
A
GKA
D
AT
G
V
E
L
E
AKWRFA
P
----
GWS
W
DI
NG
N
V
---
I
R
S
E
F
T
----
N
D
SELYH
G
N
R
V
P
FV
P
R
Y
GAG
S
SVN-
--
--
-
-
-
-
G
VID
T
R
YG
ALM
P
RLA
V
N
L
V
G
PHYFD
G
DNQLRQ
G
T
Y
ATL
D
S
SLGW
Q
A
T
E
R
MN
ISVY
VDNLFD
R
R
Y
------
R
T
Y
G
YMN
G
SS
A
VA
QV
N
M--
-
-
-
-
-
G
--
RT
--
V
GI
NT
fig|199310.1.peg.2371
Escherichia coli CFT073 (19-668/673)
I
A
N
A
QT
S
Q
---QD
ES
TLVVTA
-
S
K
QS
SR
S
A
S
AN
N
VSS
-------------
TV
V
S
APEL
S
D
A
G
V
T
ASD
K
LP
R
V
L
PG
L
N
I
---
EN
S
GN
ML
F
S
T
-----
-
I
S
L
RG
VSSA
Q
DF
YNPAVTL
Y
V
DG
V
P
QL
S
T
N
TI
----
QAL
T
D
-
--
---------
V
Q
S
VE
L
LRGP
Q
GT
L
YG
K
SA
Q
GG
I
INI
V
T
Q
QP
DSTPR
G
YI
E
G
G
V
S
S
RD
S
Y------
R
SK
F
N
L
S
GPI
-
Q
D
GL--
-
LYG
SVT
LLRQ
V
DD
GDM
IN
P
AT
G
SDDLG
---------
GT
R
AS
I
G
N
-
-----
V
K
LRL
AP
--
-
-----
-
------
-
-
-
---
--
----
D
---------------
--
-
--
--
--
-
-
-
-
-
---
-
--
--
-
---
D
QP
W
E
M
G
F
A
A
S
-----
--
-----------
RE
C
T
R
AT
QD
----
A
YV
G
WNDIK
G
RKLSISDG
S
PDPYMRR
C
T
DS
Q
TLS
GKY
T
T
D
D
WVFNL
I
S
AWQ
Q
Q
HYSR
TF
PS
GS
LI
--
V
N
M
P
Q
R
WNQ
D
V
Q
ELRAA
T
LGD
A
RTV
D
M
---
---
V
--
F
GL
Y
R
QN
TREKLNSAYDMPTMPYLS
S
T
G
Y
TT
AET
L
A
A
Y
S
DL
T
WH
LTD
R
F
D
I
G
GG
V
RF
S
-
H
DKSST
Q
YH
GSM-LGNPF
GD
Q
G
KSND
D
QVL
G
-
-
--
----------------
-
QL
S
A
G
Y
M
LT
D
D
WR
V
Y
T
R
V
A
QGYK
P
S
G
Y
N
IV
P
--
T
AG
----LDAK
P
F
V
AEKSIN
Y
E
L
GT
R
YE
TA
D
V
-
T
L
QA
AT
F
YT
H
T
KD
M
QL
Y
S
G
P
V
GM
-
Q
T
--
--
----
L
SN
A
GKA
D
AT
G
V
E
L
E
AKWRFA
P
----
GWS
W
DI
NG
N
V
---
I
R
S
E
F
T
----
N
D
SELYH
G
N
R
V
P
FV
P
R
Y
GAG
S
SVN-
--
--
-
-
-
-
G
VID
T
R
YG
ALM
P
RLA
V
N
L
V
G
PHYFD
G
DNQLRQ
G
T
Y
ATL
D
S
SLGW
Q
A
T
E
R
MN
ISVY
VDNLFD
R
R
Y
------
R
T
Y
G
YMN
G
SS
A
VA
QV
N
M--
-
-
-
-
-
G
--
RT
--
V
GI
NT
fig|199310.4.peg.2286
Escherichia coli CFT073 (19-668/673)
I
A
N
A
QT
S
Q
---QD
ES
TLVVTA
-
S
K
QS
SR
S
A
S
AN
N
VSS
-------------
TV
V
S
APEL
S
D
A
G
V
T
ASD
K
LP
R
V
L
PG
L
N
I
---
EN
S
GN
ML
F
S
T
-----
-
I
S
L
RG
VSSA
Q
DF
YNPAVTL
Y
V
DG
V
P
QL
S
T
N
TI
----
QAL
T
D
-
--
---------
V
Q
S
VE
L
LRGP
Q
GT
L
YG
K
SA
Q
GG
I
INI
V
T
Q
QP
DSTPR
G
YI
E
G
G
V
S
S
RD
S
Y------
R
SK
F
N
L
S
GPI
-
Q
D
GL--
-
LYG
SVT
LLRQ
V
DD
GDM
IN
P
AT
G
SDDLG
---------
GT
R
AS
I
G
N
-
-----
V
K
LRL
AP
--
-
-----
-
------
-
-
-
---
--
----
D
---------------
--
-
--
--
--
-
-
-
-
-
---
-
--
--
-
---
D
QP
W
E
M
G
F
A
A
S
-----
--
-----------
RE
C
T
R
AT
QD
----
A
YV
G
WNDIK
G
RKLSISDG
S
PDPYMRR
C
T
DS
Q
TLS
GKY
T
T
D
D
WVFNL
I
S
AWQ
Q
Q
HYSR
TF
PS
GS
LI
--
V
N
M
P
Q
R
WNQ
D
V
Q
ELRAA
T
LGD
A
RTV
D
M
---
---
V
--
F
GL
Y
R
QN
TREKLNSAYDMPTMPYLS
S
T
G
Y
TT
AET
L
A
A
Y
S
DL
T
WH
LTD
R
F
D
I
G
GG
V
RF
S
-
H
DKSST
Q
YH
GSM-LGNPF
GD
Q
G
KSND
D
QVL
G
-
-
--
----------------
-
QL
S
A
G
Y
M
LT
D
D
WR
V
Y
T
R
V
A
QGYK
P
S
G
Y
N
IV
P
--
T
AG
----LDAK
P
F
V
AEKSIN
Y
E
L
GT
R
YE
TA
D
V
-
T
L
QA
AT
F
YT
H
T
KD
M
QL
Y
S
G
P
V
GM
-
Q
T
--
--
----
L
SN
A
GKA
D
AT
G
V
E
L
E
AKWRFA
P
----
GWS
W
DI
NG
N
V
---
I
R
S
E
F
T
----
N
D
SELYH
G
N
R
V
P
FV
P
R
Y
GAG
S
SVN-
--
--
-
-
-
-
G
VID
T
R
YG
ALM
P
RLA
V
N
L
V
G
PHYFD
G
DNQLRQ
G
T
Y
ATL
D
S
SLGW
Q
A
T
E
R
MN
ISVY
VDNLFD
R
R
Y
------
R
T
Y
G
YMN
G
SS
A
VA
QV
N
M--
-
-
-
-
-
G
--
RT
--
V
GI
NT
fig|340186.3.peg.4166
Escherichia coli E110019 (19-668/673)
I
A
N
A
QT
S
Q
---QD
ES
TLVVTA
-
S
K
QS
SR
S
A
S
AN
N
VSS
-------------
TV
V
S
APEL
S
D
A
G
V
T
ASD
K
LP
R
V
L
PG
L
N
I
---
EN
S
GN
ML
F
S
T
-----
-
I
S
L
RG
VSSA
Q
DF
YNPAVTL
Y
V
DG
V
P
QL
S
T
N
TI
----
QAL
T
D
-
--
---------
V
Q
S
VE
L
LRGP
Q
GT
L
YG
K
SA
Q
GG
I
INI
V
T
Q
QP
DSTPR
G
YI
E
G
G
V
S
S
RD
S
Y------
R
SK
F
N
L
S
GPI
-
Q
D
GL--
-
LYG
SVT
LLRQ
V
DD
GDM
IN
P
AT
G
SDDLG
---------
GT
R
AS
I
G
N
-
-----
V
K
LRL
AP
--
-
-----
-
------
-
-
-
---
--
----
D
---------------
--
-
--
--
--
-
-
-
-
-
---
-
--
--
-
---
D
QP
W
E
M
G
F
A
A
S
-----
--
-----------
RE
C
T
R
AT
QD
----
A
YV
G
WNDIK
G
RKLSISDG
S
PDPYMRR
C
T
DS
Q
TLS
GKY
T
T
D
D
WVFNL
I
S
AWQ
Q
Q
HYSR
TF
PS
GS
LI
--
V
N
M
P
Q
R
WNQ
D
V
Q
ELRAA
T
LGD
A
RTV
D
M
---
---
V
--
F
GL
Y
R
QN
TREKLNSAYDMPTMPYLS
S
T
G
Y
TT
AET
L
A
A
Y
S
DL
T
WH
LTD
R
F
D
I
G
GG
V
RF
S
-
H
DKSST
Q
YH
GSM-LGNPF
GD
Q
G
KSND
D
QVL
G
-
-
--
----------------
-
QL
S
A
G
Y
M
LT
D
D
WR
V
Y
T
R
V
A
QGYK
P
S
G
Y
N
IV
P
--
T
AG
----LDAK
P
F
V
AEKSIN
Y
E
L
GT
R
YE
TA
D
V
-
T
L
QA
AT
F
YT
H
T
KD
M
QL
Y
S
G
P
V
GM
-
Q
T
--
--
----
L
SN
A
GKA
D
AT
G
V
E
L
E
AKWRFA
P
----
GWS
W
DI
NG
N
V
---
I
R
S
E
F
T
----
N
D
SELYH
G
N
R
V
P
FV
P
R
Y
GAG
S
SVN-
--
--
-
-
-
-
G
VID
T
R
YG
ALM
P
RLA
V
N
L
V
G
PHYFD
G
DNQLRQ
G
T
Y
ATL
D
S
SLGW
Q
A
T
E
R
MN
ISVY
VDNLFD
R
R
Y
------
R
T
Y
G
YMN
G
SS
A
VA
QV
N
M--
-
-
-
-
-
G
--
RT
--
V
GI
NT
fig|340186.5.peg.4382
Escherichia coli E110019 (19-668/673)
I
A
N
A
QT
S
Q
---QD
ES
TLVVTA
-
S
K
QS
SR
S
A
S
AN
N
VSS
-------------
TV
V
S
APEL
S
D
A
G
V
T
ASD
K
LP
R
V
L
PG
L
N
I
---
EN
S
GN
ML
F
S
T
-----
-
I
S
L
RG
VSSA
Q
DF
YNPAVTL
Y
V
DG
V
P
QL
S
T
N
TI
----
QAL
T
D
-
--
---------
V
Q
S
VE
L
LRGP
Q
GT
L
YG
K
SA
Q
GG
I
INI
V
T
Q
QP
DSTPR
G
YI
E
G
G
V
S
S
RD
S
Y------
R
SK
F
N
L
S
GPI
-
Q
D
GL--
-
LYG
SVT
LLRQ
V
DD
GDM
IN
P
AT
G
SDDLG
---------
GT
R
AS
I
G
N
-
-----
V
K
LRL
AP
--
-
-----
-
------
-
-
-
---
--
----
D
---------------
--
-
--
--
--
-
-
-
-
-
---
-
--
--
-
---
D
QP
W
E
M
G
F
A
A
S
-----
--
-----------
RE
C
T
R
AT
QD
----
A
YV
G
WNDIK
G
RKLSISDG
S
PDPYMRR
C
T
DS
Q
TLS
GKY
T
T
D
D
WVFNL
I
S
AWQ
Q
Q
HYSR
TF
PS
GS
LI
--
V
N
M
P
Q
R
WNQ
D
V
Q
ELRAA
T
LGD
A
RTV
D
M
---
---
V
--
F
GL
Y
R
QN
TREKLNSAYDMPTMPYLS
S
T
G
Y
TT
AET
L
A
A
Y
S
DL
T
WH
LTD
R
F
D
I
G
GG
V
RF
S
-
H
DKSST
Q
YH
GSM-LGNPF
GD
Q
G
KSND
D
QVL
G
-
-
--
----------------
-
QL
S
A
G
Y
M
LT
D
D
WR
V
Y
T
R
V
A
QGYK
P
S
G
Y
N
IV
P
--
T
AG
----LDAK
P
F
V
AEKSIN
Y
E
L
GT
R
YE
TA
D
V
-
T
L
QA
AT
F
YT
H
T
KD
M
QL
Y
S
G
P
V
GM
-
Q
T
--
--
----
L
SN
A
GKA
D
AT
G
V
E
L
E
AKWRFA
P
----
GWS
W
DI
NG
N
V
---
I
R
S
E
F
T
----
N
D
SELYH
G
N
R
V
P
FV
P
R
Y
GAG
S
SVN-
--
--
-
-
-
-
G
VID
T
R
YG
ALM
P
RLA
V
N
L
V
G
PHYFD
G
DNQLRQ
G
T
Y
ATL
D
S
SLGW
Q
A
T
E
R
MN
ISVY
VDNLFD
R
R
Y
------
R
T
Y
G
YMN
G
SS
A
VA
QV
N
M--
-
-
-
-
-
G
--
RT
--
V
GI
NT
fig|340197.3.peg.4216
Escherichia coli F11 (19-668/673)
I
A
N
A
QT
S
Q
---QD
ES
TLVVTA
-
S
K
QS
SR
S
A
S
AN
N
VSS
-------------
TV
V
S
APEL
S
D
A
G
V
T
ASD
K
LP
R
V
L
PG
L
N
I
---
EN
S
GN
ML
F
S
T
-----
-
I
S
L
RG
VSSA
Q
DF
YNPAVTL
Y
V
DG
V
P
QL
S
T
N
TI
----
QAL
T
D
-
--
---------
V
Q
S
VE
L
LRGP
Q
GT
L
YG
K
SA
Q
GG
I
INI
V
T
Q
QP
DSTPR
G
YI
E
G
G
V
S
S
RD
S
Y------
R
SK
F
N
L
S
GPI
-
Q
D
GL--
-
LYG
SVT
LLRQ
V
DD
GDM
IN
P
AT
G
SDDLG
---------
GT
R
AS
I
G
N
-
-----
V
K
LRL
AP
--
-
-----
-
------
-
-
-
---
--
----
D
---------------
--
-
--
--
--
-
-
-
-
-
---
-
--
--
-
---
D
QP
W
E
M
G
F
A
A
S
-----
--
-----------
RE
C
T
R
AT
QD
----
A
YV
G
WNDIK
G
RKLSISDG
S
PDPYMRR
C
T
DS
Q
TLS
GKY
T
T
D
D
WVFNL
I
S
AWQ
Q
Q
HYSR
TF
PS
GS
LI
--
V
N
M
P
Q
R
WNQ
D
V
Q
ELRAA
T
LGD
A
RTV
D
M
---
---
V
--
F
GL
Y
R
QN
TREKLNSAYDMPTMPYLS
S
T
G
Y
TT
AET
L
A
A
Y
S
DL
T
WH
LTD
R
F
D
I
G
GG
V
RF
S
-
H
DKSST
Q
YH
GSM-LGNPF
GD
Q
G
KSND
D
QVL
G
-
-
--
----------------
-
QL
S
A
G
Y
M
LT
D
D
WR
V
Y
T
R
V
A
QGYK
P
S
G
Y
N
IV
P
--
T
AG
----LDAK
P
F
V
AEKSIN
Y
E
L
GT
R
YE
TA
D
V
-
T
L
QA
AT
F
YT
H
T
KD
M
QL
Y
S
G
P
V
GM
-
Q
T
--
--
----
L
SN
A
GKA
D
AT
G
V
E
L
E
AKWRFA
P
----
GWS
W
DI
NG
N
V
---
I
R
S
E
F
T
----
N
D
SELYH
G
N
R
V
P
FV
P
R
Y
GAG
S
SVN-
--
--
-
-
-
-
G
VID
T
R
YG
ALM
P
RLA
V
N
L
V
G
PHYFD
G
DNQLRQ
G
T
Y
ATL
D
S
SLGW
Q
A
T
E
R
MN
ISVY
VDNLFD
R
R
Y
------
R
T
Y
G
YMN
G
SS
A
VA
QV
N
M--
-
-
-
-
-
G
--
RT
--
V
GI
NT
fig|340197.5.peg.4401
Escherichia coli F11 (19-668/673)
I
A
N
A
QT
S
Q
---QD
ES
TLVVTA
-
S
K
QS
SR
S
A
S
AN
N
VSS
-------------
TV
V
S
APEL
S
D
A
G
V
T
ASD
K
LP
R
V
L
PG
L
N
I
---
EN
S
GN
ML
F
S
T
-----
-
I
S
L
RG
VSSA
Q
DF
YNPAVTL
Y
V
DG
V
P
QL
S
T
N
TI
----
QAL
T
D
-
--
---------
V
Q
S
VE
L
LRGP
Q
GT
L
YG
K
SA
Q
GG
I
INI
V
T
Q
QP
DSTPR
G
YI
E
G
G
V
S
S
RD
S
Y------
R
SK
F
N
L
S
GPI
-
Q
D
GL--
-
LYG
SVT
LLRQ
V
DD
GDM
IN
P
AT
G
SDDLG
---------
GT
R
AS
I
G
N
-
-----
V
K
LRL
AP
--
-
-----
-
------
-
-
-
---
--
----
D
---------------
--
-
--
--
--
-
-
-
-
-
---
-
--
--
-
---
D
QP
W
E
M
G
F
A
A
S
-----
--
-----------
RE
C
T
R
AT
QD
----
A
YV
G
WNDIK
G
RKLSISDG
S
PDPYMRR
C
T
DS
Q
TLS
GKY
T
T
D
D
WVFNL
I
S
AWQ
Q
Q
HYSR
TF
PS
GS
LI
--
V
N
M
P
Q
R
WNQ
D
V
Q
ELRAA
T
LGD
A
RTV
D
M
---
---
V
--
F
GL
Y
R
QN
TREKLNSAYDMPTMPYLS
S
T
G
Y
TT
AET
L
A
A
Y
S
DL
T
WH
LTD
R
F
D
I
G
GG
V
RF
S
-
H
DKSST
Q
YH
GSM-LGNPF
GD
Q
G
KSND
D
QVL
G
-
-
--
----------------
-
QL
S
A
G
Y
M
LT
D
D
WR
V
Y
T
R
V
A
QGYK
P
S
G
Y
N
IV
P
--
T
AG
----LDAK
P
F
V
AEKSIN
Y
E
L
GT
R
YE
TA
D
V
-
T
L
QA
AT
F
YT
H
T
KD
M
QL
Y
S
G
P
V
GM
-
Q
T
--
--
----
L
SN
A
GKA
D
AT
G
V
E
L
E
AKWRFA
P
----
GWS
W
DI
NG
N
V
---
I
R
S
E
F
T
----
N
D
SELYH
G
N
R
V
P
FV
P
R
Y
GAG
S
SVN-
--
--
-
-
-
-
G
VID
T
R
YG
ALM
P
RLA
V
N
L
V
G
PHYFD
G
DNQLRQ
G
T
Y
ATL
D
S
SLGW
Q
A
T
E
R
MN
ISVY
VDNLFD
R
R
Y
------
R
T
Y
G
YMN
G
SS
A
VA
QV
N
M--
-
-
-
-
-
G
--
RT
--
V
GI
NT
fig|656379.3.peg.2471
Escherichia coli FVEC1302 (19-668/673)
I
A
N
A
QT
S
Q
---QD
ES
TLVVTA
-
S
K
QS
SR
S
A
S
AN
N
VSS
-------------
TV
V
S
APEL
S
D
A
G
V
T
ASD
K
LP
R
V
L
PG
L
N
I
---
EN
S
GN
ML
F
S
T
-----
-
I
S
L
RG
VSSA
Q
DF
YNPAVTL
Y
V
DG
V
P
QL
S
T
N
TI
----
QAL
T
D
-
--
---------
V
Q
S
VE
L
LRGP
Q
GT
L
YG
K
SA
Q
GG
I
INI
V
T
Q
QP
DSTPR
G
YI
E
G
G
V
S
S
RD
S
Y------
R
SK
F
N
L
S
GPI
-
Q
D
GL--
-
LYG
SVT
LLRQ
V
DD
GDM
IN
P
AT
G
SDDLG
---------
GT
R
AS
I
G
N
-
-----
V
K
LRL
AP
--
-
-----
-
------
-
-
-
---
--
----
D
---------------
--
-
--
--
--
-
-
-
-
-
---
-
--
--
-
---
D
QP
W
E
M
G
F
A
A
S
-----
--
-----------
RE
C
T
R
AT
QD
----
A
YV
G
WNDIK
G
RKLSISDG
S
PDPYMRR
C
T
DS
Q
TLS
GKY
T
T
D
D
WVFNL
I
S
AWQ
Q
Q
HYSR
TF
PS
GS
LI
--
V
N
M
P
Q
R
WNQ
D
V
Q
ELRAA
T
LGD
A
RTV
D
M
---
---
V
--
F
GL
Y
R
QN
TREKLNSAYDMPTMPYLS
S
T
G
Y
TT
AET
L
A
A
Y
S
DL
T
WH
LTD
R
F
D
I
G
GG
V
RF
S
-
H
DKSST
Q
YH
GSM-LGNPF
GD
Q
G
KSND
D
QVL
G
-
-
--
----------------
-
QL
S
A
G
Y
M
LT
D
D
WR
V
Y
T
R
V
A
QGYK
P
S
G
Y
N
IV
P
--
T
AG
----LDAK
P
F
V
AEKSIN
Y
E
L
GT
R
YE
TA
D
V
-
T
L
QA
AT
F
YT
H
T
KD
M
QL
Y
S
G
P
V
GM
-
Q
T
--
--
----
L
SN
A
GKA
D
AT
G
V
E
L
E
AKWRFA
P
----
GWS
W
DI
NG
N
V
---
I
R
S
E
F
T
----
N
D
SELYH
G
N
R
V
P
FV
P
R
Y
GAG
S
SVN-
--
--
-
-
-
-
G
VID
T
R
YG
ALM
P
RLA
V
N
L
V
G
PHYFD
G
DNQLRQ
G
T
Y
ATL
D
S
SLGW
Q
A
T
E
R
MN
ISVY
VDNLFD
R
R
Y
------
R
T
Y
G
YMN
G
SS
A
VA
QV
N
M--
-
-
-
-
-
G
--
RT
--
V
GI
NT
fig|714962.3.peg.2193
Escherichia coli IHE3034 (19-668/673)
I
A
N
A
QT
S
Q
---QD
ES
TLVVTA
-
S
K
QS
SR
S
A
S
AN
N
VSS
-------------
TV
V
S
APEL
S
D
A
G
V
T
ASD
K
LP
R
V
L
PG
L
N
I
---
EN
S
GN
ML
F
S
T
-----
-
I
S
L
RG
VSSA
Q
DF
YNPAVTL
Y
V
DG
V
P
QL
S
T
N
TI
----
QAL
T
D
-
--
---------
V
Q
S
VE
L
LRGP
Q
GT
L
YG
K
SA
Q
GG
I
INI
V
T
Q
QP
DSTPR
G
YI
E
G
G
V
S
S
RD
S
Y------
R
SK
F
N
L
S
GPI
-
Q
D
GL--
-
LYG
SVT
LLRQ
V
DD
GDM
IN
P
AT
G
SDDLG
---------
GT
R
AS
I
G
N
-
-----
V
K
LRL
AP
--
-
-----
-
------
-
-
-
---
--
----
D
---------------
--
-
--
--
--
-
-
-
-
-
---
-
--
--
-
---
D
QP
W
E
M
G
F
A
A
S
-----
--
-----------
RE
C
T
R
AT
QD
----
A
YV
G
WNDIK
G
RKLSISDG
S
PDPYMRR
C
T
DS
Q
TLS
GKY
T
T
D
D
WVFNL
I
S
AWQ
Q
Q
HYSR
TF
PS
GS
LI
--
V
N
M
P
Q
R
WNQ
D
V
Q
ELRAA
T
LGD
A
RTV
D
M
---
---
V
--
F
GL
Y
R
QN
TREKLNSAYDMPTMPYLS
S
T
G
Y
TT
AET
L
A
A
Y
S
DL
T
WH
LTD
R
F
D
I
G
GG
V
RF
S
-
H
DKSST
Q
YH
GSM-LGNPF
GD
Q
G
KSND
D
QVL
G
-
-
--
----------------
-
QL
S
A
G
Y
M
LT
D
D
WR
V
Y
T
R
V
A
QGYK
P
S
G
Y
N
IV
P
--
T
AG
----LDAK
P
F
V
AEKSIN
Y
E
L
GT
R
YE
TA
D
V
-
T
L
QA
AT
F
YT
H
T
KD
M
QL
Y
S
G
P
V
GM
-
Q
T
--
--
----
L
SN
A
GKA
D
AT
G
V
E
L
E
AKWRFA
P
----
GWS
W
DI
NG
N
V
---
I
R
S
E
F
T
----
N
D
SELYH
G
N
R
V
P
FV
P
R
Y
GAG
S
SVN-
--
--
-
-
-
-
G
VID
T
R
YG
ALM
P
RLA
V
N
L
V
G
PHYFD
G
DNQLRQ
G
T
Y
ATL
D
S
SLGW
Q
A
T
E
R
MN
ISVY
VDNLFD
R
R
Y
------
R
T
Y
G
YMN
G
SS
A
VA
QV
N
M--
-
-
-
-
-
G
--
RT
--
V
GI
NT
fig|656417.3.peg.2595
Escherichia coli M605 (19-668/673)
I
A
N
A
QT
S
Q
---QD
ES
TLVVTA
-
S
K
QS
SR
S
A
S
AN
N
VSS
-------------
TV
V
S
APEL
S
D
A
G
V
T
ASD
K
LP
R
V
L
PG
L
N
I
---
EN
S
GN
ML
F
S
T
-----
-
I
S
L
RG
VSSA
Q
DF
YNPAVTL
Y
V
DG
V
P
QL
S
T
N
TI
----
QAL
T
D
-
--
---------
V
Q
S
VE
L
LRGP
Q
GT
L
YG
K
SA
Q
GG
I
INI
V
T
Q
QP
DSTPR
G
YI
E
G
G
V
S
S
RD
S
Y------
R
SK
F
N
L
S
GPI
-
Q
D
GL--
-
LYG
SVT
LLRQ
V
DD
GDM
IN
P
AT
G
SDDLG
---------
GT
R
AS
I
G
N
-
-----
V
K
LRL
AP
--
-
-----
-
------
-
-
-
---
--
----
D
---------------
--
-
--
--
--
-
-
-
-
-
---
-
--
--
-
---
D
QP
W
E
M
G
F
A
A
S
-----
--
-----------
RE
C
T
R
AT
QD
----
A
YV
G
WNDIK
G
RKLSISDG
S
PDPYMRR
C
T
DS
Q
TLS
GKY
T
T
D
D
WVFNL
I
S
AWQ
Q
Q
HYSR
TF
PS
GS
LI
--
V
N
M
P
Q
R
WNQ
D
V
Q
ELRAA
T
LGD
A
RTV
D
M
---
---
V
--
F
GL
Y
R
QN
TREKLNSAYDMPTMPYLS
S
T
G
Y
TT
AET
L
A
A
Y
S
DL
T
WH
LTD
R
F
D
I
G
GG
V
RF
S
-
H
DKSST
Q
YH
GSM-LGNPF
GD
Q
G
KSND
D
QVL
G
-
-
--
----------------
-
QL
S
A
G
Y
M
LT
D
D
WR
V
Y
T
R
V
A
QGYK
P
S
G
Y
N
IV
P
--
T
AG
----LDAK
P
F
V
AEKSIN
Y
E
L
GT
R
YE
TA
D
V
-
T
L
QA
AT
F
YT
H
T
KD
M
QL
Y
S
G
P
V
GM
-
Q
T
--
--
----
L
SN
A
GKA
D
AT
G
V
E
L
E
AKWRFA
P
----
GWS
W
DI
NG
N
V
---
I
R
S
E
F
T
----
N
D
SELYH
G
N
R
V
P
FV
P
R
Y
GAG
S
SVN-
--
--
-
-
-
-
G
VID
T
R
YG
ALM
P
RLA
V
N
L
V
G
PHYFD
G
DNQLRQ
G
T
Y
ATL
D
S
SLGW
Q
A
T
E
R
MN
ISVY
VDNLFD
R
R
Y
------
R
T
Y
G
YMN
G
SS
A
VA
QV
N
M--
-
-
-
-
-
G
--
RT
--
V
GI
NT
fig|679205.4.peg.2712
Escherichia coli MS 124-1 (19-668/673)
I
A
N
A
QT
S
Q
---QD
ES
TLVVTA
-
S
K
QS
SR
S
A
S
AN
N
VSS
-------------
TV
V
S
APEL
S
D
A
G
V
T
ASD
K
LP
R
V
L
PG
L
N
I
---
EN
S
GN
ML
F
S
T
-----
-
I
S
L
RG
VSSA
Q
DF
YNPAVTL
Y
V
DG
V
P
QL
S
T
N
TI
----
QAL
T
D
-
--
---------
V
Q
S
VE
L
LRGP
Q
GT
L
YG
K
SA
Q
GG
I
INI
V
T
Q
QP
DSTPR
G
YI
E
G
G
V
S
S
RD
S
Y------
R
SK
F
N
L
S
GPI
-
Q
D
GL--
-
LYG
SVT
LLRQ
V
DD
GDM
IN
P
AT
G
SDDLG
---------
GT
R
AS
I
G
N
-
-----
V
K
LRL
AP
--
-
-----
-
------
-
-
-
---
--
----
D
---------------
--
-
--
--
--
-
-
-
-
-
---
-
--
--
-
---
D
QP
W
E
M
G
F
A
A
S
-----
--
-----------
RE
C
T
R
AT
QD
----
A
YV
G
WNDIK
G
RKLSISDG
S
PDPYMRR
C
T
DS
Q
TLS
GKY
T
T
D
D
WVFNL
I
S
AWQ
Q
Q
HYSR
TF
PS
GS
LI
--
V
N
M
P
Q
R
WNQ
D
V
Q
ELRAA
T
LGD
A
RTV
D
M
---
---
V
--
F
GL
Y
R
QN
TREKLNSAYDMPTMPYLS
S
T
G
Y
TT
AET
L
A
A
Y
S
DL
T
WH
LTD
R
F
D
I
G
GG
V
RF
S
-
H
DKSST
Q
YH
GSM-LGNPF
GD
Q
G
KSND
D
QVL
G
-
-
--
----------------
-
QL
S
A
G
Y
M
LT
D
D
WR
V
Y
T
R
V
A
QGYK
P
S
G
Y
N
IV
P
--
T
AG
----LDAK
P
F
V
AEKSIN
Y
E
L
GT
R
YE
TA
D
V
-
T
L
QA
AT
F
YT
H
T
KD
M
QL
Y
S
G
P
V
GM
-
Q
T
--
--
----
L
SN
A
GKA
D
AT
G
V
E
L
E
AKWRFA
P
----
GWS
W
DI
NG
N
V
---
I
R
S
E
F
T
----
N
D
SELYH
G
N
R
V
P
FV
P
R
Y
GAG
S
SVN-
--
--
-
-
-
-
G
VID
T
R
YG
ALM
P
RLA
V
N
L
V
G
PHYFD
G
DNQLRQ
G
T
Y
ATL
D
S
SLGW
Q
A
T
E
R
MN
ISVY
VDNLFD
R
R
Y
------
R
T
Y
G
YMN
G
SS
A
VA
QV
N
M--
-
-
-
-
-
G
--
RT
--
V
GI
NT
fig|749544.3.peg.2213
Escherichia coli MS 175-1 (19-668/673)
I
A
N
A
QT
S
Q
---QD
ES
TLVVTA
-
S
K
QS
SR
S
A
S
AN
N
VSS
-------------
TV
V
S
APEL
S
D
A
G
V
T
ASD
K
LP
R
V
L
PG
L
N
I
---
EN
S
GN
ML
F
S
T
-----
-
I
S
L
RG
VSSA
Q
DF
YNPAVTL
Y
V
DG
V
P
QL
S
T
N
TI
----
QAL
T
D
-
--
---------
V
Q
S
VE
L
LRGP
Q
GT
L
YG
K
SA
Q
GG
I
INI
V
T
Q
QP
DSTPR
G
YI
E
G
G
V
S
S
RD
S
Y------
R
SK
F
N
L
S
GPI
-
Q
D
GL--
-
LYG
SVT
LLRQ
V
DD
GDM
IN
P
AT
G
SDDLG
---------
GT
R
AS
I
G
N
-
-----
V
K
LRL
AP
--
-
-----
-
------
-
-
-
---
--
----
D
---------------
--
-
--
--
--
-
-
-
-
-
---
-
--
--
-
---
D
QP
W
E
M
G
F
A
A
S
-----
--
-----------
RE
C
T
R
AT
QD
----
A
YV
G
WNDIK
G
RKLSISDG
S
PDPYMRR
C
T
DS
Q
TLS
GKY
T
T
D
D
WVFNL
I
S
AWQ
Q
Q
HYSR
TF
PS
GS
LI
--
V
N
M
P
Q
R
WNQ
D
V
Q
ELRAA
T
LGD
A
RTV
D
M
---
---
V
--
F
GL
Y
R
QN
TREKLNSAYDMPTMPYLS
S
T
G
Y
TT
AET
L
A
A
Y
S
DL
T
WH
LTD
R
F
D
I
G
GG
V
RF
S
-
H
DKSST
Q
YH
GSM-LGNPF
GD
Q
G
KSND
D
QVL
G
-
-
--
----------------
-
QL
S
A
G
Y
M
LT
D
D
WR
V
Y
T
R
V
A
QGYK
P
S
G
Y
N
IV
P
--
T
AG
----LDAK
P
F
V
AEKSIN
Y
E
L
GT
R
YE
TA
D
V
-
T
L
QA
AT
F
YT
H
T
KD
M
QL
Y
S
G
P
V
GM
-
Q
T
--
--
----
L
SN
A
GKA
D
AT
G
V
E
L
E
AKWRFA
P
----
GWS
W
DI
NG
N
V
---
I
R
S
E
F
T
----
N
D
SELYH
G
N
R
V
P
FV
P
R
Y
GAG
S
SVN-
--
--
-
-
-
-
G
VID
T
R
YG
ALM
P
RLA
V
N
L
V
G
PHYFD
G
DNQLRQ
G
T
Y
ATL
D
S
SLGW
Q
A
T
E
R
MN
ISVY
VDNLFD
R
R
Y
------
R
T
Y
G
YMN
G
SS
A
VA
QV
N
M--
-
-
-
-
-
G
--
RT
--
V
GI
NT
fig|749546.3.peg.532
Escherichia coli MS 185-1 (19-668/673)
I
A
N
A
QT
S
Q
---QD
ES
TLVVTA
-
S
K
QS
SR
S
A
S
AN
N
VSS
-------------
TV
V
S
APEL
S
D
A
G
V
T
ASD
K
LP
R
V
L
PG
L
N
I
---
EN
S
GN
ML
F
S
T
-----
-
I
S
L
RG
VSSA
Q
DF
YNPAVTL
Y
V
DG
V
P
QL
S
T
N
TI
----
QAL
T
D
-
--
---------
V
Q
S
VE
L
LRGP
Q
GT
L
YG
K
SA
Q
GG
I
INI
V
T
Q
QP
DSTPR
G
YI
E
G
G
V
S
S
RD
S
Y------
R
SK
F
N
L
S
GPI
-
Q
D
GL--
-
LYG
SVT
LLRQ
V
DD
GDM
IN
P
AT
G
SDDLG
---------
GT
R
AS
I
G
N
-
-----
V
K
LRL
AP
--
-
-----
-
------
-
-
-
---
--
----
D
---------------
--
-
--
--
--
-
-
-
-
-
---
-
--
--
-
---
D
QP
W
E
M
G
F
A
A
S
-----
--
-----------
RE
C
T
R
AT
QD
----
A
YV
G
WNDIK
G
RKLSISDG
S
PDPYMRR
C
T
DS
Q
TLS
GKY
T
T
D
D
WVFNL
I
S
AWQ
Q
Q
HYSR
TF
PS
GS
LI
--
V
N
M
P
Q
R
WNQ
D
V
Q
ELRAA
T
LGD
A
RTV
D
M
---
---
V
--
F
GL
Y
R
QN
TREKLNSAYDMPTMPYLS
S
T
G
Y
TT
AET
L
A
A
Y
S
DL
T
WH
LTD
R
F
D
I
G
GG
V
RF
S
-
H
DKSST
Q
YH
GSM-LGNPF
GD
Q
G
KSND
D
QVL
G
-
-
--
----------------
-
QL
S
A
G
Y
M
LT
D
D
WR
V
Y
T
R
V
A
QGYK
P
S
G
Y
N
IV
P
--
T
AG
----LDAK
P
F
V
AEKSIN
Y
E
L
GT
R
YE
TA
D
V
-
T
L
QA
AT
F
YT
H
T
KD
M
QL
Y
S
G
P
V
GM
-
Q
T
--
--
----
L
SN
A
GKA
D
AT
G
V
E
L
E
AKWRFA
P
----
GWS
W
DI
NG
N
V
---
I
R
S
E
F
T
----
N
D
SELYH
G
N
R
V
P
FV
P
R
Y
GAG
S
SVN-
--
--
-
-
-
-
G
VID
T
R
YG
ALM
P
RLA
V
N
L
V
G
PHYFD
G
DNQLRQ
G
T
Y
ATL
D
S
SLGW
Q
A
T
E
R
MN
ISVY
VDNLFD
R
R
Y
------
R
T
Y
G
YMN
G
SS
A
VA
QV
N
M--
-
-
-
-
-
G
--
RT
--
V
GI
NT
fig|749548.3.peg.876
Escherichia coli MS 196-1 (19-668/673)
I
A
N
A
QT
S
Q
---QD
ES
TLVVTA
-
S
K
QS
SR
S
A
S
AN
N
VSS
-------------
TV
V
S
APEL
S
D
A
G
V
T
ASD
K
LP
R
V
L
PG
L
N
I
---
EN
S
GN
ML
F
S
T
-----
-
I
S
L
RG
VSSA
Q
DF
YNPAVTL
Y
V
DG
V
P
QL
S
T
N
TI
----
QAL
T
D
-
--
---------
V
Q
S
VE
L
LRGP
Q
GT
L
YG
K
SA
Q
GG
I
INI
V
T
Q
QP
DSTPR
G
YI
E
G
G
V
S
S
RD
S
Y------
R
SK
F
N
L
S
GPI
-
Q
D
GL--
-
LYG
SVT
LLRQ
V
DD
GDM
IN
P
AT
G
SDDLG
---------
GT
R
AS
I
G
N
-
-----
V
K
LRL
AP
--
-
-----
-
------
-
-
-
---
--
----
D
---------------
--
-
--
--
--
-
-
-
-
-
---
-
--
--
-
---
D
QP
W
E
M
G
F
A
A
S
-----
--
-----------
RE
C
T
R
AT
QD
----
A
YV
G
WNDIK
G
RKLSISDG
S
PDPYMRR
C
T
DS
Q
TLS
GKY
T
T
D
D
WVFNL
I
S
AWQ
Q
Q
HYSR
TF
PS
GS
LI
--
V
N
M
P
Q
R
WNQ
D
V
Q
ELRAA
T
LGD
A
RTV
D
M
---
---
V
--
F
GL
Y
R
QN
TREKLNSAYDMPTMPYLS
S
T
G
Y
TT
AET
L
A
A
Y
S
DL
T
WH
LTD
R
F
D
I
G
GG
V
RF
S
-
H
DKSST
Q
YH
GSM-LGNPF
GD
Q
G
KSND
D
QVL
G
-
-
--
----------------
-
QL
S
A
G
Y
M
LT
D
D
WR
V
Y
T
R
V
A
QGYK
P
S
G
Y
N
IV
P
--
T
AG
----LDAK
P
F
V
AEKSIN
Y
E
L
GT
R
YE
TA
D
V
-
T
L
QA
AT
F
YT
H
T
KD
M
QL
Y
S
G
P
V
GM
-
Q
T
--
--
----
L
SN
A
GKA
D
AT
G
V
E
L
E
AKWRFA
P
----
GWS
W
DI
NG
N
V
---
I
R
S
E
F
T
----
N
D
SELYH
G
N
R
V
P
FV
P
R
Y
GAG
S
SVN-
--
--
-
-
-
-
G
VID
T
R
YG
ALM
P
RLA
V
N
L
V
G
PHYFD
G
DNQLRQ
G
T
Y
ATL
D
S
SLGW
Q
A
T
E
R
MN
ISVY
VDNLFD
R
R
Y
------
R
T
Y
G
YMN
G
SS
A
VA
QV
N
M--
-
-
-
-
-
G
--
RT
--
V
GI
NT
fig|749527.3.peg.5515
Escherichia coli MS 21-1 (19-668/673)
I
A
N
A
QT
S
Q
---QD
ES
TLVVTA
-
S
K
QS
SR
S
A
S
AN
N
VSS
-------------
TV
V
S
APEL
S
D
A
G
V
T
ASD
K
LP
R
V
L
PG
L
N
I
---
EN
S
GN
ML
F
S
T
-----
-
I
S
L
RG
VSSA
Q
DF
YNPAVTL
Y
V
DG
V
P
QL
S
T
N
TI
----
QAL
T
D
-
--
---------
V
Q
S
VE
L
LRGP
Q
GT
L
YG
K
SA
Q
GG
I
INI
V
T
Q
QP
DSTPR
G
YI
E
G
G
V
S
S
RD
S
Y------
R
SK
F
N
L
S
GPI
-
Q
D
GL--
-
LYG
SVT
LLRQ
V
DD
GDM
IN
P
AT
G
SDDLG
---------
GT
R
AS
I
G
N
-
-----
V
K
LRL
AP
--
-
-----
-
------
-
-
-
---
--
----
D
---------------
--
-
--
--
--
-
-
-
-
-
---
-
--
--
-
---
D
QP
W
E
M
G
F
A
A
S
-----
--
-----------
RE
C
T
R
AT
QD
----
A
YV
G
WNDIK
G
RKLSISDG
S
PDPYMRR
C
T
DS
Q
TLS
GKY
T
T
D
D
WVFNL
I
S
AWQ
Q
Q
HYSR
TF
PS
GS
LI
--
V
N
M
P
Q
R
WNQ
D
V
Q
ELRAA
T
LGD
A
RTV
D
M
---
---
V
--
F
GL
Y
R
QN
TREKLNSAYDMPTMPYLS
S
T
G
Y
TT
AET
L
A
A
Y
S
DL
T
WH
LTD
R
F
D
I
G
GG
V
RF
S
-
H
DKSST
Q
YH
GSM-LGNPF
GD
Q
G
KSND
D
QVL
G
-
-
--
----------------
-
QL
S
A
G
Y
M
LT
D
D
WR
V
Y
T
R
V
A
QGYK
P
S
G
Y
N
IV
P
--
T
AG
----LDAK
P
F
V
AEKSIN
Y
E
L
GT
R
YE
TA
D
V
-
T
L
QA
AT
F
YT
H
T
KD
M
QL
Y
S
G
P
V
GM
-
Q
T
--
--
----
L
SN
A
GKA
D
AT
G
V
E
L
E
AKWRFA
P
----
GWS
W
DI
NG
N
V
---
I
R
S
E
F
T
----
N
D
SELYH
G
N
R
V
P
FV
P
R
Y
GAG
S
SVN-
--
--
-
-
-
-
G
VID
T
R
YG
ALM
P
RLA
V
N
L
V
G
PHYFD
G
DNQLRQ
G
T
Y
ATL
D
S
SLGW
Q
A
T
E
R
MN
ISVY
VDNLFD
R
R
Y
------
R
T
Y
G
YMN
G
SS
A
VA
QV
N
M--
-
-
-
-
-
G
--
RT
--
V
GI
NT
fig|749528.3.peg.913
Escherichia coli MS 45-1 (19-668/673)
I
A
N
A
QT
S
Q
---QD
ES
TLVVTA
-
S
K
QS
SR
S
A
S
AN
N
VSS
-------------
TV
V
S
APEL
S
D
A
G
V
T
ASD
K
LP
R
V
L
PG
L
N
I
---
EN
S
GN
ML
F
S
T
-----
-
I
S
L
RG
VSSA
Q
DF
YNPAVTL
Y
V
DG
V
P
QL
S
T
N
TI
----
QAL
T
D
-
--
---------
V
Q
S
VE
L
LRGP
Q
GT
L
YG
K
SA
Q
GG
I
INI
V
T
Q
QP
DSTPR
G
YI
E
G
G
V
S
S
RD
S
Y------
R
SK
F
N
L
S
GPI
-
Q
D
GL--
-
LYG
SVT
LLRQ
V
DD
GDM
IN
P
AT
G
SDDLG
---------
GT
R
AS
I
G
N
-
-----
V
K
LRL
AP
--
-
-----
-
------
-
-
-
---
--
----
D
---------------
--
-
--
--
--
-
-
-
-
-
---
-
--
--
-
---
D
QP
W
E
M
G
F
A
A
S
-----
--
-----------
RE
C
T
R
AT
QD
----
A
YV
G
WNDIK
G
RKLSISDG
S
PDPYMRR
C
T
DS
Q
TLS
GKY
T
T
D
D
WVFNL
I
S
AWQ
Q
Q
HYSR
TF
PS
GS
LI
--
V
N
M
P
Q
R
WNQ
D
V
Q
ELRAA
T
LGD
A
RTV
D
M
---
---
V
--
F
GL
Y
R
QN
TREKLNSAYDMPTMPYLS
S
T
G
Y
TT
AET
L
A
A
Y
S
DL
T
WH
LTD
R
F
D
I
G
GG
V
RF
S
-
H
DKSST
Q
YH
GSM-LGNPF
GD
Q
G
KSND
D
QVL
G
-
-
--
----------------
-
QL
S
A
G
Y
M
LT
D
D
WR
V
Y
T
R
V
A
QGYK
P
S
G
Y
N
IV
P
--
T
AG
----LDAK
P
F
V
AEKSIN
Y
E
L
GT
R
YE
TA
D
V
-
T
L
QA
AT
F
YT
H
T
KD
M
QL
Y
S
G
P
V
GM
-
Q
T
--
--
----
L
SN
A
GKA
D
AT
G
V
E
L
E
AKWRFA
P
----
GWS
W
DI
NG
N
V
---
I
R
S
E
F
T
----
N
D
SELYH
G
N
R
V
P
FV
P
R
Y
GAG
S
SVN-
--
--
-
-
-
-
G
VID
T
R
YG
ALM
P
RLA
V
N
L
V
G
PHYFD
G
DNQLRQ
G
T
Y
ATL
D
S
SLGW
Q
A
T
E
R
MN
ISVY
VDNLFD
R
R
Y
------
R
T
Y
G
YMN
G
SS
A
VA
QV
N
M--
-
-
-
-
-
G
--
RT
--
V
GI
NT
fig|749533.3.peg.152
Escherichia coli MS 84-1 (19-668/673)
I
A
N
A
QT
S
Q
---QD
ES
TLVVTA
-
S
K
QS
SR
S
A
S
AN
N
VSS
-------------
TV
V
S
APEL
S
D
A
G
V
T
ASD
K
LP
R
V
L
PG
L
N
I
---
EN
S
GN
ML
F
S
T
-----
-
I
S
L
RG
VSSA
Q
DF
YNPAVTL
Y
V
DG
V
P
QL
S
T
N
TI
----
QAL
T
D
-
--
---------
V
Q
S
VE
L
LRGP
Q
GT
L
YG
K
SA
Q
GG
I
INI
V
T
Q
QP
DSTPR
G
YI
E
G
G
V
S
S
RD
S
Y------
R
SK
F
N
L
S
GPI
-
Q
D
GL--
-
LYG
SVT
LLRQ
V
DD
GDM
IN
P
AT
G
SDDLG
---------
GT
R
AS
I
G
N
-
-----
V
K
LRL
AP
--
-
-----
-
------
-
-
-
---
--
----
D
---------------
--
-
--
--
--
-
-
-
-
-
---
-
--
--
-
---
D
QP
W
E
M
G
F
A
A
S
-----
--
-----------
RE
C
T
R
AT
QD
----
A
YV
G
WNDIK
G
RKLSISDG
S
PDPYMRR
C
T
DS
Q
TLS
GKY
T
T
D
D
WVFNL
I
S
AWQ
Q
Q
HYSR
TF
PS
GS
LI
--
V
N
M
P
Q
R
WNQ
D
V
Q
ELRAA
T
LGD
A
RTV
D
M
---
---
V
--
F
GL
Y
R
QN
TREKLNSAYDMPTMPYLS
S
T
G
Y
TT
AET
L
A
A
Y
S
DL
T
WH
LTD
R
F
D
I
G
GG
V
RF
S
-
H
DKSST
Q
YH
GSM-LGNPF
GD
Q
G
KSND
D
QVL
G
-
-
--
----------------
-
QL
S
A
G
Y
M
LT
D
D
WR
V
Y
T
R
V
A
QGYK
P
S
G
Y
N
IV
P
--
T
AG
----LDAK
P
F
V
AEKSIN
Y
E
L
GT
R
YE
TA
D
V
-
T
L
QA
AT
F
YT
H
T
KD
M
QL
Y
S
G
P
V
GM
-
Q
T
--
--
----
L
SN
A
GKA
D
AT
G
V
E
L
E
AKWRFA
P
----
GWS
W
DI
NG
N
V
---
I
R
S
E
F
T
----
N
D
SELYH
G
N
R
V
P
FV
P
R
Y
GAG
S
SVN-
--
--
-
-
-
-
G
VID
T
R
YG
ALM
P
RLA
V
N
L
V
G
PHYFD
G
DNQLRQ
G
T
Y
ATL
D
S
SLGW
Q
A
T
E
R
MN
ISVY
VDNLFD
R
R
Y
------
R
T
Y
G
YMN
G
SS
A
VA
QV
N
M--
-
-
-
-
-
G
--
RT
--
V
GI
NT
fig|753642.3.peg.2329
Escherichia coli NC101 (19-668/673)
I
A
N
A
QT
S
Q
---QD
ES
TLVVTA
-
S
K
QS
SR
S
A
S
AN
N
VSS
-------------
TV
V
S
APEL
S
D
A
G
V
T
ASD
K
LP
R
V
L
PG
L
N
I
---
EN
S
GN
ML
F
S
T
-----
-
I
S
L
RG
VSSA
Q
DF
YNPAVTL
Y
V
DG
V
P
QL
S
T
N
TI
----
QAL
T
D
-
--
---------
V
Q
S
VE
L
LRGP
Q
GT
L
YG
K
SA
Q
GG
I
INI
V
T
Q
QP
DSTPR
G
YI
E
G
G
V
S
S
RD
S
Y------
R
SK
F
N
L
S
GPI
-
Q
D
GL--
-
LYG
SVT
LLRQ
V
DD
GDM
IN
P
AT
G
SDDLG
---------
GT
R
AS
I
G
N
-
-----
V
K
LRL
AP
--
-
-----
-
------
-
-
-
---
--
----
D
---------------
--
-
--
--
--
-
-
-
-
-
---
-
--
--
-
---
D
QP
W
E
M
G
F
A
A
S
-----
--
-----------
RE
C
T
R
AT
QD
----
A
YV
G
WNDIK
G
RKLSISDG
S
PDPYMRR
C
T
DS
Q
TLS
GKY
T
T
D
D
WVFNL
I
S
AWQ
Q
Q
HYSR
TF
PS
GS
LI
--
V
N
M
P
Q
R
WNQ
D
V
Q
ELRAA
T
LGD
A
RTV
D
M
---
---
V
--
F
GL
Y
R
QN
TREKLNSAYDMPTMPYLS
S
T
G
Y
TT
AET
L
A
A
Y
S
DL
T
WH
LTD
R
F
D
I
G
GG
V
RF
S
-
H
DKSST
Q
YH
GSM-LGNPF
GD
Q
G
KSND
D
QVL
G
-
-
--
----------------
-
QL
S
A
G
Y
M
LT
D
D
WR
V
Y
T
R
V
A
QGYK
P
S
G
Y
N
IV
P
--
T
AG
----LDAK
P
F
V
AEKSIN
Y
E
L
GT
R
YE
TA
D
V
-
T
L
QA
AT
F
YT
H
T
KD
M
QL
Y
S
G
P
V
GM
-
Q
T
--
--
----
L
SN
A
GKA
D
AT
G
V
E
L
E
AKWRFA
P
----
GWS
W
DI
NG
N
V
---
I
R
S
E
F
T
----
N
D
SELYH
G
N
R
V
P
FV
P
R
Y
GAG
S
SVN-
--
--
-
-
-
-
G
VID
T
R
YG
ALM
P
RLA
V
N
L
V
G
PHYFD
G
DNQLRQ
G
T
Y
ATL
D
S
SLGW
Q
A
T
E
R
MN
ISVY
VDNLFD
R
R
Y
------
R
T
Y
G
YMN
G
SS
A
VA
QV
N
M--
-
-
-
-
-
G
--
RT
--
V
GI
NT
fig|685038.3.peg.2001
Escherichia coli O83:H1 str. NRG 857C (19-668/673)
I
A
N
A
QT
S
Q
---QD
ES
TLVVTA
-
S
K
QS
SR
S
A
S
AN
N
VSS
-------------
TV
V
S
APEL
S
D
A
G
V
T
ASD
K
LP
R
V
L
PG
L
N
I
---
EN
S
GN
ML
F
S
T
-----
-
I
S
L
RG
VSSA
Q
DF
YNPAVTL
Y
V
DG
V
P
QL
S
T
N
TI
----
QAL
T
D
-
--
---------
V
Q
S
VE
L
LRGP
Q
GT
L
YG
K
SA
Q
GG
I
INI
V
T
Q
QP
DSTPR
G
YI
E
G
G
V
S
S
RD
S
Y------
R
SK
F
N
L
S
GPI
-
Q
D
GL--
-
LYG
SVT
LLRQ
V
DD
GDM
IN
P
AT
G
SDDLG
---------
GT
R
AS
I
G
N
-
-----
V
K
LRL
AP
--
-
-----
-
------
-
-
-
---
--
----
D
---------------
--
-
--
--
--
-
-
-
-
-
---
-
--
--
-
---
D
QP
W
E
M
G
F
A
A
S
-----
--
-----------
RE
C
T
R
AT
QD
----
A
YV
G
WNDIK
G
RKLSISDG
S
PDPYMRR
C
T
DS
Q
TLS
GKY
T
T
D
D
WVFNL
I
S
AWQ
Q
Q
HYSR
TF
PS
GS
LI
--
V
N
M
P
Q
R
WNQ
D
V
Q
ELRAA
T
LGD
A
RTV
D
M
---
---
V
--
F
GL
Y
R
QN
TREKLNSAYDMPTMPYLS
S
T
G
Y
TT
AET
L
A
A
Y
S
DL
T
WH
LTD
R
F
D
I
G
GG
V
RF
S
-
H
DKSST
Q
YH
GSM-LGNPF
GD
Q
G
KSND
D
QVL
G
-
-
--
----------------
-
QL
S
A
G
Y
M
LT
D
D
WR
V
Y
T
R
V
A
QGYK
P
S
G
Y
N
IV
P
--
T
AG
----LDAK
P
F
V
AEKSIN
Y
E
L
GT
R
YE
TA
D
V
-
T
L
QA
AT
F
YT
H
T
KD
M
QL
Y
S
G
P
V
GM
-
Q
T
--
--
----
L
SN
A
GKA
D
AT
G
V
E
L
E
AKWRFA
P
----
GWS
W
DI
NG
N
V
---
I
R
S
E
F
T
----
N
D
SELYH
G
N
R
V
P
FV
P
R
Y
GAG
S
SVN-
--
--
-
-
-
-
G
VID
T
R
YG
ALM
P
RLA
V
N
L
V
G
PHYFD
G
DNQLRQ
G
T
Y
ATL
D
S
SLGW
Q
A
T
E
R
MN
ISVY
VDNLFD
R
R
Y
------
R
T
Y
G
YMN
G
SS
A
VA
QV
N
M--
-
-
-
-
-
G
--
RT
--
V
GI
NT
fig|431946.3.peg.1912
Escherichia coli SE15 (19-668/673)
I
A
N
A
QT
S
Q
---QD
ES
TLVVTA
-
S
K
QS
SR
S
A
S
AN
N
VSS
-------------
TV
V
S
APEL
S
D
A
G
V
T
ASD
K
LP
R
V
L
PG
L
N
I
---
EN
S
GN
ML
F
S
T
-----
-
I
S
L
RG
VSSA
Q
DF
YNPAVTL
Y
V
DG
V
P
QL
S
T
N
TI
----
QAL
T
D
-
--
---------
V
Q
S
VE
L
LRGP
Q
GT
L
YG
K
SA
Q
GG
I
INI
V
T
Q
QP
DSTPR
G
YI
E
G
G
V
S
S
RD
S
Y------
R
SK
F
N
L
S
GPI
-
Q
D
GL--
-
LYG
SVT
LLRQ
V
DD
GDM
IN
P
AT
G
SDDLG
---------
GT
R
AS
I
G
N
-
-----
V
K
LRL
AP
--
-
-----
-
------
-
-
-
---
--
----
D
---------------
--
-
--
--
--
-
-
-
-
-
---
-
--
--
-
---
D
QP
W
E
M
G
F
A
A
S
-----
--
-----------
RE
C
T
R
AT
QD
----
A
YV
G
WNDIK
G
RKLSISDG
S
PDPYMRR
C
T
DS
Q
TLS
GKY
T
T
D
D
WVFNL
I
S
AWQ
Q
Q
HYSR
TF
PS
GS
LI
--
V
N
M
P
Q
R
WNQ
D
V
Q
ELRAA
T
LGD
A
RTV
D
M
---
---
V
--
F
GL
Y
R
QN
TREKLNSAYDMPTMPYLS
S
T
G
Y
TT
AET
L
A
A
Y
S
DL
T
WH
LTD
R
F
D
I
G
GG
V
RF
S
-
H
DKSST
Q
YH
GSM-LGNPF
GD
Q
G
KSND
D
QVL
G
-
-
--
----------------
-
QL
S
A
G
Y
M
LT
D
D
WR
V
Y
T
R
V
A
QGYK
P
S
G
Y
N
IV
P
--
T
AG
----LDAK
P
F
V
AEKSIN
Y
E
L
GT
R
YE
TA
D
V
-
T
L
QA
AT
F
YT
H
T
KD
M
QL
Y
S
G
P
V
GM
-
Q
T
--
--
----
L
SN
A
GKA
D
AT
G
V
E
L
E
AKWRFA
P
----
GWS
W
DI
NG
N
V
---
I
R
S
E
F
T
----
N
D
SELYH
G
N
R
V
P
FV
P
R
Y
GAG
S
SVN-
--
--
-
-
-
-
G
VID
T
R
YG
ALM
P
RLA
V
N
L
V
G
PHYFD
G
DNQLRQ
G
T
Y
ATL
D
S
SLGW
Q
A
T
E
R
MN
ISVY
VDNLFD
R
R
Y
------
R
T
Y
G
YMN
G
SS
A
VA
QV
N
M--
-
-
-
-
-
G
--
RT
--
V
GI
NT
fig|585056.7.peg.2465
Escherichia coli UMN026 (19-668/673)
I
A
N
A
QT
S
Q
---QD
ES
TLVVTA
-
S
K
QS
SR
S
A
S
AN
N
VSS
-------------
TV
V
S
APEL
S
D
A
G
V
T
ASD
K
LP
R
V
L
PG
L
N
I
---
EN
S
GN
ML
F
S
T
-----
-
I
S
L
RG
VSSA
Q
DF
YNPAVTL
Y
V
DG
V
P
QL
S
T
N
TI
----
QAL
T
D
-
--
---------
V
Q
S
VE
L
LRGP
Q
GT
L
YG
K
SA
Q
GG
I
INI
V
T
Q
QP
DSTPR
G
YI
E
G
G
V
S
S
RD
S
Y------
R
SK
F
N
L
S
GPI
-
Q
D
GL--
-
LYG
SVT
LLRQ
V
DD
GDM
IN
P
AT
G
SDDLG
---------
GT
R
AS
I
G
N
-
-----
V
K
LRL
AP
--
-
-----
-
------
-
-
-
---
--
----
D
---------------
--
-
--
--
--
-
-
-
-
-
---
-
--
--
-
---
D
QP
W
E
M
G
F
A
A
S
-----
--
-----------
RE
C
T
R
AT
QD
----
A
YV
G
WNDIK
G
RKLSISDG
S
PDPYMRR
C
T
DS
Q
TLS
GKY
T
T
D
D
WVFNL
I
S
AWQ
Q
Q
HYSR
TF
PS
GS
LI
--
V
N
M
P
Q
R
WNQ
D
V
Q
ELRAA
T
LGD
A
RTV
D
M
---
---
V
--
F
GL
Y
R
QN
TREKLNSAYDMPTMPYLS
S
T
G
Y
TT
AET
L
A
A
Y
S
DL
T
WH
LTD
R
F
D
I
G
GG
V
RF
S
-
H
DKSST
Q
YH
GSM-LGNPF
GD
Q
G
KSND
D
QVL
G
-
-
--
----------------
-
QL
S
A
G
Y
M
LT
D
D
WR
V
Y
T
R
V
A
QGYK
P
S
G
Y
N
IV
P
--
T
AG
----LDAK
P
F
V
AEKSIN
Y
E
L
GT
R
YE
TA
D
V
-
T
L
QA
AT
F
YT
H
T
KD
M
QL
Y
S
G
P
V
GM
-
Q
T
--
--
----
L
SN
A
GKA
D
AT
G
V
E
L
E
AKWRFA
P
----
GWS
W
DI
NG
N
V
---
I
R
S
E
F
T
----
N
D
SELYH
G
N
R
V
P
FV
P
R
Y
GAG
S
SVN-
--
--
-
-
-
-
G
VID
T
R
YG
ALM
P
RLA
V
N
L
V
G
PHYFD
G
DNQLRQ
G
T
Y
ATL
D
S
SLGW
Q
A
T
E
R
MN
ISVY
VDNLFD
R
R
Y
------
R
T
Y
G
YMN
G
SS
A
VA
QV
N
M--
-
-
-
-
-
G
--
RT
--
V
GI
NT
fig|585397.7.peg.2283
Escherichia coli ED1a (19-668/673)
I
A
N
A
QT
S
Q
---QD
ES
TLVVTA
-
S
K
QS
SR
S
A
S
AN
N
VSS
-------------
TV
V
S
APEL
S
D
A
G
V
T
ASD
K
LP
R
V
L
PG
L
N
I
---
EN
S
GN
ML
F
S
T
-----
-
I
S
L
RG
VSSA
Q
DF
YNPAVTL
Y
V
DG
V
P
QL
S
T
N
TI
----
QAL
T
D
-
--
---------
V
Q
S
VE
L
LRGP
Q
GT
L
YG
K
SA
Q
GG
I
INI
V
T
Q
QP
DSTPR
G
YI
E
G
G
V
S
S
RD
S
Y------
R
SK
F
N
L
S
GPI
-
Q
D
GL--
-
LYG
SVT
LLRQ
V
DD
GDM
IN
P
AT
G
SDDLG
---------
GT
R
AS
I
G
N
-
-----
V
K
LRL
AP
--
-
-----
-
------
-
-
-
---
--
----
D
---------------
--
-
--
--
--
-
-
-
-
-
---
-
--
--
-
---
D
QP
W
E
M
G
F
A
A
S
-----
--
-----------
RE
C
T
R
AT
QD
----
A
YV
G
WNDIK
G
RKLSISDG
S
PDPYMRR
C
T
DS
Q
TLS
GKY
T
T
D
D
WVFNL
I
S
AWQ
Q
Q
HYSR
TF
PS
GS
LI
--
V
N
I
P
Q
R
WNQ
D
V
Q
ELRAA
T
LGD
A
RTV
D
M
---
---
V
--
F
GL
Y
R
QN
TREKLNSAYDMPTMPYLS
S
T
G
Y
TT
AET
L
A
A
Y
S
DL
T
WH
LTD
R
F
D
I
G
GG
V
RF
S
-
H
DKSST
Q
YH
GSM-LGNPF
GD
Q
G
KSND
D
QVL
G
-
-
--
----------------
-
QL
S
A
G
Y
M
LT
D
D
WR
V
Y
T
R
V
A
QGYK
P
S
G
Y
N
IV
P
--
T
AG
----LDAK
P
F
V
AEKSIN
Y
E
L
GT
R
YE
TA
D
V
-
T
L
QA
AT
F
YT
H
T
KD
M
QL
Y
S
G
P
V
GM
-
Q
T
--
--
----
L
SN
A
GKA
D
AT
G
V
E
L
E
AKWRFA
P
----
GWS
W
DI
NG
N
V
---
I
R
S
E
F
T
----
N
D
SELYH
G
N
R
V
P
FV
P
R
Y
GAG
S
SVN-
--
--
-
-
-
-
G
VID
T
R
YG
ALM
P
RLA
V
N
L
V
G
PHYFD
G
DNQLRQ
G
T
Y
ATL
D
S
SLGW
Q
A
T
E
R
MN
ISVY
VDNLFD
R
R
Y
------
R
T
Y
G
YMN
G
SS
A
VA
QV
N
M--
-
-
-
-
-
G
--
RT
--
V
GI
NT
fig|585397.9.peg.2280
Escherichia coli ED1a (19-668/673)
I
A
N
A
QT
S
Q
---QD
ES
TLVVTA
-
S
K
QS
SR
S
A
S
AN
N
VSS
-------------
TV
V
S
APEL
S
D
A
G
V
T
ASD
K
LP
R
V
L
PG
L
N
I
---
EN
S
GN
ML
F
S
T
-----
-
I
S
L
RG
VSSA
Q
DF
YNPAVTL
Y
V
DG
V
P
QL
S
T
N
TI
----
QAL
T
D
-
--
---------
V
Q
S
VE
L
LRGP
Q
GT
L
YG
K
SA
Q
GG
I
INI
V
T
Q
QP
DSTPR
G
YI
E
G
G
V
S
S
RD
S
Y------
R
SK
F
N
L
S
GPI
-
Q
D
GL--
-
LYG
SVT
LLRQ
V
DD
GDM
IN
P
AT
G
SDDLG
---------
GT
R
AS
I
G
N
-
-----
V
K
LRL
AP
--
-
-----
-
------
-
-
-
---
--
----
D
---------------
--
-
--
--
--
-
-
-
-
-
---
-
--
--
-
---
D
QP
W
E
M
G
F
A
A
S
-----
--
-----------
RE
C
T
R
AT
QD
----
A
YV
G
WNDIK
G
RKLSISDG
S
PDPYMRR
C
T
DS
Q
TLS
GKY
T
T
D
D
WVFNL
I
S
AWQ
Q
Q
HYSR
TF
PS
GS
LI
--
V
N
I
P
Q
R
WNQ
D
V
Q
ELRAA
T
LGD
A
RTV
D
M
---
---
V
--
F
GL
Y
R
QN
TREKLNSAYDMPTMPYLS
S
T
G
Y
TT
AET
L
A
A
Y
S
DL
T
WH
LTD
R
F
D
I
G
GG
V
RF
S
-
H
DKSST
Q
YH
GSM-LGNPF
GD
Q
G
KSND
D
QVL
G
-
-
--
----------------
-
QL
S
A
G
Y
M
LT
D
D
WR
V
Y
T
R
V
A
QGYK
P
S
G
Y
N
IV
P
--
T
AG
----LDAK
P
F
V
AEKSIN
Y
E
L
GT
R
YE
TA
D
V
-
T
L
QA
AT
F
YT
H
T
KD
M
QL
Y
S
G
P
V
GM
-
Q
T
--
--
----
L
SN
A
GKA
D
AT
G
V
E
L
E
AKWRFA
P
----
GWS
W
DI
NG
N
V
---
I
R
S
E
F
T
----
N
D
SELYH
G
N
R
V
P
FV
P
R
Y
GAG
S
SVN-
--
--
-
-
-
-
G
VID
T
R
YG
ALM
P
RLA
V
N
L
V
G
PHYFD
G
DNQLRQ
G
T
Y
ATL
D
S
SLGW
Q
A
T
E
R
MN
ISVY
VDNLFD
R
R
Y
------
R
T
Y
G
YMN
G
SS
A
VA
QV
N
M--
-
-
-
-
-
G
--
RT
--
V
GI
NT
fig|405955.13.peg.2135
Escherichia coli APEC O1 (19-668/673)
I
A
N
A
QT
S
Q
---QD
ES
TLVVTA
-
S
K
QS
SR
S
A
S
AN
N
VSS
-------------
TV
V
S
APEL
S
D
A
G
V
T
ASD
K
LP
R
V
L
PG
L
N
I
---
EN
S
GN
ML
F
S
T
-----
-
I
S
L
RG
VSSA
Q
DF
YNPAVTL
Y
V
DG
V
P
QL
S
T
N
TI
----
QAL
T
D
-
--
---------
V
Q
S
VE
L
LRGP
Q
GT
L
YG
K
SA
Q
GG
I
INI
V
T
Q
QP
DSTPR
G
YI
E
G
G
V
S
S
RD
S
Y------
R
SK
F
N
L
S
GPI
-
Q
D
GL--
-
LYG
SVT
LLRQ
V
DD
GDM
IN
P
AT
G
SDDLG
---------
GT
R
AS
I
G
N
-
-----
V
K
LRL
AP
--
-
-----
-
------
-
-
-
---
--
----
D
---------------
--
-
--
--
--
-
-
-
-
-
---
-
--
--
-
---
D
QP
W
E
M
G
F
A
A
S
-----
--
-----------
RE
C
T
R
AT
QD
----
A
YV
G
WNDIK
G
RKLSISDG
S
PDPYMRR
C
T
DS
Q
TLS
GKY
T
T
D
D
WVFNL
I
S
AWQ
Q
Q
HYSR
A
F
PS
GS
LI
--
V
N
M
P
Q
R
WNQ
D
V
Q
ELRAA
T
LGD
A
RTV
D
M
---
---
V
--
F
GL
Y
R
QN
TREKLNSAYDMPTMPYLS
S
T
G
Y
TT
AET
L
A
A
Y
S
DL
T
WH
LTD
R
F
D
I
G
GG
V
RF
S
-
H
DKSST
Q
YH
GSM-LGNPF
GD
Q
G
KSND
D
QVL
G
-
-
--
----------------
-
QL
S
A
G
Y
M
LT
D
D
WR
V
Y
T
R
V
A
QGYK
P
S
G
Y
N
IV
P
--
T
AG
----LDAK
P
F
V
AEKSIN
Y
E
L
GT
R
YE
TA
D
V
-
T
L
QA
AT
F
YT
H
T
KD
M
QL
Y
S
G
P
V
GM
-
Q
T
--
--
----
L
SN
A
GKA
D
AT
G
V
E
L
E
AKWRFA
P
----
GWS
W
DI
NG
N
V
---
I
R
S
E
F
T
----
N
D
SELYH
G
N
R
V
P
FV
P
R
Y
GAG
S
SVN-
--
--
-
-
-
-
G
VID
T
R
YG
ALM
P
RLA
V
N
L
V
G
PHYFD
G
DNQLRQ
G
T
Y
ATL
D
S
SLGW
Q
A
T
E
R
MN
ISVY
VDNLFD
R
R
Y
------
R
T
Y
G
YMN
G
SS
A
VA
QV
N
M--
-
-
-
-
-
G
--
RT
--
V
GI
NT
fig|405955.9.peg.1743
Escherichia coli APEC O1 (19-668/673)
I
A
N
A
QT
S
Q
---QD
ES
TLVVTA
-
S
K
QS
SR
S
A
S
AN
N
VSS
-------------
TV
V
S
APEL
S
D
A
G
V
T
ASD
K
LP
R
V
L
PG
L
N
I
---
EN
S
GN
ML
F
S
T
-----
-
I
S
L
RG
VSSA
Q
DF
YNPAVTL
Y
V
DG
V
P
QL
S
T
N
TI
----
QAL
T
D
-
--
---------
V
Q
S
VE
L
LRGP
Q
GT
L
YG
K
SA
Q
GG
I
INI
V
T
Q
QP
DSTPR
G
YI
E
G
G
V
S
S
RD
S
Y------
R
SK
F
N
L
S
GPI
-
Q
D
GL--
-
LYG
SVT
LLRQ
V
DD
GDM
IN
P
AT
G
SDDLG
---------
GT
R
AS
I
G
N
-
-----
V
K
LRL
AP
--
-
-----
-
------
-
-
-
---
--
----
D
---------------
--
-
--
--
--
-
-
-
-
-
---
-
--
--
-
---
D
QP
W
E
M
G
F
A
A
S
-----
--
-----------
RE
C
T
R
AT
QD
----
A
YV
G
WNDIK
G
RKLSISDG
S
PDPYMRR
C
T
DS
Q
TLS
GKY
T
T
D
D
WVFNL
I
S
AWQ
Q
Q
HYSR
A
F
PS
GS
LI
--
V
N
M
P
Q
R
WNQ
D
V
Q
ELRAA
T
LGD
A
RTV
D
M
---
---
V
--
F
GL
Y
R
QN
TREKLNSAYDMPTMPYLS
S
T
G
Y
TT
AET
L
A
A
Y
S
DL
T
WH
LTD
R
F
D
I
G
GG
V
RF
S
-
H
DKSST
Q
YH
GSM-LGNPF
GD
Q
G
KSND
D
QVL
G
-
-
--
----------------
-
QL
S
A
G
Y
M
LT
D
D
WR
V
Y
T
R
V
A
QGYK
P
S
G
Y
N
IV
P
--
T
AG
----LDAK
P
F
V
AEKSIN
Y
E
L
GT
R
YE
TA
D
V
-
T
L
QA
AT
F
YT
H
T
KD
M
QL
Y
S
G
P
V
GM
-
Q
T
--
--
----
L
SN
A
GKA
D
AT
G
V
E
L
E
AKWRFA
P
----
GWS
W
DI
NG
N
V
---
I
R
S
E
F
T
----
N
D
SELYH
G
N
R
V
P
FV
P
R
Y
GAG
S
SVN-
--
--
-
-
-
-
G
VID
T
R
YG
ALM
P
RLA
V
N
L
V
G
PHYFD
G
DNQLRQ
G
T
Y
ATL
D
S
SLGW
Q
A
T
E
R
MN
ISVY
VDNLFD
R
R
Y
------
R
T
Y
G
YMN
G
SS
A
VA
QV
N
M--
-
-
-
-
-
G
--
RT
--
V
GI
NT
fig|749549.3.peg.3965
Escherichia coli MS 198-1 (19-668/673)
I
A
N
A
QT
S
Q
---QD
ES
TLVVTA
-
S
K
QS
SR
S
A
S
AN
N
VSS
-------------
TV
V
S
APEL
S
D
A
G
V
T
ASD
K
LP
R
V
L
PG
L
N
I
---
EN
S
GN
ML
F
S
T
-----
-
I
S
L
RG
VSSA
Q
DF
YNPAVTL
Y
V
DG
V
P
QL
S
T
N
TI
----
QAL
T
D
-
--
---------
V
Q
S
VE
L
LRGP
Q
GT
L
YG
K
SA
Q
GG
I
INI
V
T
Q
QP
DSTPR
G
YI
E
G
G
V
S
S
RD
S
Y------
R
SK
F
N
L
S
GPI
-
Q
D
GL--
-
LYG
SVT
LLRQ
V
DD
GDM
IN
P
AT
G
SDDLG
---------
GT
R
AS
I
G
N
-
-----
V
K
LRL
AP
--
-
-----
-
------
-
-
-
---
--
----
D
---------------
--
-
--
--
--
-
-
-
-
-
---
-
--
--
-
---
D
QP
W
E
M
G
F
A
A
S
-----
--
-----------
RE
C
T
R
AT
QD
----
A
YV
G
WNDIK
G
RKLSISDG
S
PDPYMRR
C
T
DS
Q
TLS
GKY
T
T
D
D
WVFNL
I
S
AWQ
Q
Q
HYSR
A
F
PS
GS
LI
--
V
N
M
P
Q
R
WNQ
D
V
Q
ELRAA
T
LGD
A
RTV
D
M
---
---
V
--
F
GL
Y
R
QN
TREKLNSAYDMPTMPYLS
S
T
G
Y
TT
AET
L
A
A
Y
S
DL
T
WH
LTD
R
F
D
I
G
GG
V
RF
S
-
H
DKSST
Q
YH
GSM-LGNPF
GD
Q
G
KSND
D
QVL
G
-
-
--
----------------
-
QL
S
A
G
Y
M
LT
D
D
WR
V
Y
T
R
V
A
QGYK
P
S
G
Y
N
IV
P
--
T
AG
----LDAK
P
F
V
AEKSIN
Y
E
L
GT
R
YE
TA
D
V
-
T
L
QA
AT
F
YT
H
T
KD
M
QL
Y
S
G
P
V
GM
-
Q
T
--
--
----
L
SN
A
GKA
D
AT
G
V
E
L
E
AKWRFA
P
----
GWS
W
DI
NG
N
V
---
I
R
S
E
F
T
----
N
D
SELYH
G
N
R
V
P
FV
P
R
Y
GAG
S
SVN-
--
--
-
-
-
-
G
VID
T
R
YG
ALM
P
RLA
V
N
L
V
G
PHYFD
G
DNQLRQ
G
T
Y
ATL
D
S
SLGW
Q
A
T
E
R
MN
ISVY
VDNLFD
R
R
Y
------
R
T
Y
G
YMN
G
SS
A
VA
QV
N
M--
-
-
-
-
-
G
--
RT
--
V
GI
NT
fig|749531.3.peg.509
Escherichia coli MS 69-1 (19-668/673)
I
A
N
A
QT
S
Q
---QD
ES
TLVVTA
-
S
K
QS
SR
S
A
S
AN
N
VSS
-------------
TV
V
S
APEL
S
D
A
G
V
T
ASD
K
LP
R
V
L
PG
L
N
I
---
EN
S
GN
ML
F
S
T
-----
-
I
S
L
RG
VSSA
Q
DF
YNPAVTL
Y
V
DG
V
P
QL
S
T
N
TI
----
QAL
T
D
-
--
---------
V
Q
S
VE
L
LRGP
Q
GT
L
YG
K
SA
Q
GG
I
INI
V
T
Q
QP
DSTPR
G
YI
E
G
G
V
S
S
RD
S
Y------
R
SK
F
N
L
S
GPI
-
Q
D
GL--
-
LYG
SVT
LLRQ
V
DD
GDM
IN
P
AT
G
SDDLG
---------
GT
R
AS
I
G
N
-
-----
V
K
LRL
AP
--
-
-----
-
------
-
-
-
---
--
----
D
---------------
--
-
--
--
--
-
-
-
-
-
---
-
--
--
-
---
D
QP
W
E
M
G
F
A
A
S
-----
--
-----------
RE
C
T
R
AT
QD
----
A
YV
G
WNDIK
G
RKLSISDG
S
PDPYMRR
C
T
DS
Q
TLS
GKY
T
T
D
D
WVFNL
I
S
AWQ
Q
Q
HYSR
A
F
PS
GS
LI
--
V
N
M
P
Q
R
WNQ
D
V
Q
ELRAA
T
LGD
A
RTV
D
M
---
---
V
--
F
GL
Y
R
QN
TREKLNSAYDMPTMPYLS
S
T
G
Y
TT
AET
L
A
A
Y
S
DL
T
WH
LTD
R
F
D
I
G
GG
V
RF
S
-
H
DKSST
Q
YH
GSM-LGNPF
GD
Q
G
KSND
D
QVL
G
-
-
--
----------------
-
QL
S
A
G
Y
M
LT
D
D
WR
V
Y
T
R
V
A
QGYK
P
S
G
Y
N
IV
P
--
T
AG
----LDAK
P
F
V
AEKSIN
Y
E
L
GT
R
YE
TA
D
V
-
T
L
QA
AT
F
YT
H
T
KD
M
QL
Y
S
G
P
V
GM
-
Q
T
--
--
----
L
SN
A
GKA
D
AT
G
V
E
L
E
AKWRFA
P
----
GWS
W
DI
NG
N
V
---
I
R
S
E
F
T
----
N
D
SELYH
G
N
R
V
P
FV
P
R
Y
GAG
S
SVN-
--
--
-
-
-
-
G
VID
T
R
YG
ALM
P
RLA
V
N
L
V
G
PHYFD
G
DNQLRQ
G
T
Y
ATL
D
S
SLGW
Q
A
T
E
R
MN
ISVY
VDNLFD
R
R
Y
------
R
T
Y
G
YMN
G
SS
A
VA
QV
N
M--
-
-
-
-
-
G
--
RT
--
V
GI
NT
fig|585035.6.peg.2029
Escherichia coli S88 (19-668/673)
I
A
N
A
QT
S
Q
---QD
ES
TLVVTA
-
S
K
QS
SR
S
A
S
AN
N
VSS
-------------
TV
V
S
APEL
S
D
A
G
V
T
ASD
K
LP
R
V
L
PG
L
N
I
---
EN
S
GN
ML
F
S
T
-----
-
I
S
L
RG
VSSA
Q
DF
YNPAVTL
Y
V
DG
V
P
QL
S
T
N
TI
----
QAL
T
D
-
--
---------
V
Q
S
VE
L
LRGP
Q
GT
L
YG
K
SA
Q
GG
I
INI
V
T
Q
QP
DSTPR
G
YI
E
G
G
V
S
S
RD
S
Y------
R
SK
F
N
L
S
GPI
-
Q
D
GL--
-
LYG
SVT
LLRQ
V
DD
GDM
IN
P
AT
G
SDDLG
---------
GT
R
AS
I
G
N
-
-----
V
K
LRL
AP
--
-
-----
-
------
-
-
-
---
--
----
D
---------------
--
-
--
--
--
-
-
-
-
-
---
-
--
--
-
---
D
QP
W
E
M
G
F
A
A
S
-----
--
-----------
RE
C
T
R
AT
QD
----
A
YV
G
WNDIK
G
RKLSISDG
S
PDPYMRR
C
T
DS
Q
TLS
GKY
T
T
D
D
WVFNL
I
S
AWQ
Q
Q
HYSR
A
F
PS
GS
LI
--
V
N
M
P
Q
R
WNQ
D
V
Q
ELRAA
T
LGD
A
RTV
D
M
---
---
V
--
F
GL
Y
R
QN
TREKLNSAYDMPTMPYLS
S
T
G
Y
TT
AET
L
A
A
Y
S
DL
T
WH
LTD
R
F
D
I
G
GG
V
RF
S
-
H
DKSST
Q
YH
GSM-LGNPF
GD
Q
G
KSND
D
QVL
G
-
-
--
----------------
-
QL
S
A
G
Y
M
LT
D
D
WR
V
Y
T
R
V
A
QGYK
P
S
G
Y
N
IV
P
--
T
AG
----LDAK
P
F
V
AEKSIN
Y
E
L
GT
R
YE
TA
D
V
-
T
L
QA
AT
F
YT
H
T
KD
M
QL
Y
S
G
P
V
GM
-
Q
T
--
--
----
L
SN
A
GKA
D
AT
G
V
E
L
E
AKWRFA
P
----
GWS
W
DI
NG
N
V
---
I
R
S
E
F
T
----
N
D
SELYH
G
N
R
V
P
FV
P
R
Y
GAG
S
SVN-
--
--
-
-
-
-
G
VID
T
R
YG
ALM
P
RLA
V
N
L
V
G
PHYFD
G
DNQLRQ
G
T
Y
ATL
D
S
SLGW
Q
A
T
E
R
MN
ISVY
VDNLFD
R
R
Y
------
R
T
Y
G
YMN
G
SS
A
VA
QV
N
M--
-
-
-
-
-
G
--
RT
--
V
GI
NT
fig|216592.1.peg.5534
Escherichia coli 042 (19-668/673)
I
A
N
A
QT
S
Q
---QD
ES
TLVVTA
-
S
K
QS
SR
S
A
S
AN
N
VSS
-------------
TV
V
S
APEL
S
D
A
G
V
T
ASD
K
LP
R
V
L
PG
L
N
I
---
EN
S
GN
ML
F
S
T
-----
-
I
S
L
RG
VSSA
Q
DF
YNPAVTL
Y
V
DG
V
P
QL
S
T
N
TI
----
QAL
T
D
-
--
---------
V
Q
S
VE
L
LRGP
Q
GT
L
YG
K
SA
Q
GG
I
INI
V
T
Q
QP
DSTPR
G
YI
E
G
G
V
S
S
RD
S
Y------
R
SK
F
N
L
S
GPI
-
Q
D
GL--
-
LYG
SVT
LLRQ
V
DD
GDM
IN
P
AT
G
SDDLG
---------
GT
R
AS
I
G
N
-
-----
V
K
LRL
AP
--
-
-----
-
------
-
-
-
---
--
----
D
---------------
--
-
--
--
--
-
-
-
-
-
---
-
--
--
-
---
D
QP
W
E
M
G
F
A
A
S
-----
--
-----------
RE
C
T
R
AT
QD
----
A
YV
G
WNDIK
G
RKLSISDG
S
PDPYMRR
C
T
DS
Q
TLS
GKY
T
T
D
D
WVFNL
I
S
AWQ
Q
Q
HYSR
TF
PS
GS
LI
--
V
N
M
P
Q
R
WNQ
D
V
Q
ELRAA
T
LGD
A
RTV
D
M
---
---
V
--
F
GL
Y
R
QN
TREKLNSAYDMPTMPYLS
S
T
G
Y
TT
AET
L
A
A
Y
S
DL
T
WH
LTD
R
F
D
I
G
GG
V
RF
S
-
H
DKSST
Q
YH
GSM-LGNPF
GD
Q
G
KSND
D
QVL
G
-
-
--
----------------
-
QL
S
A
G
Y
M
LT
D
D
WR
V
Y
T
R
V
A
QGYK
P
S
G
Y
N
IV
P
--
T
AG
----LDAK
P
F
V
AEKSIN
Y
E
L
GT
R
YE
TA
D
V
-
T
L
QA
AT
F
YT
H
T
KD
M
QL
Y
S
G
P
V
GM
-
K
T
--
--
----
L
SN
A
GKA
D
AT
G
V
E
L
E
AKWRFA
P
----
GWS
W
DI
NG
N
V
---
I
R
S
E
F
T
----
N
D
SELYH
G
N
R
V
P
FV
P
R
Y
GAG
S
SVN-
--
--
-
-
-
-
G
VID
T
R
YG
ALM
P
RLA
V
N
L
V
G
PHYFD
G
DNQLRQ
G
T
Y
ATL
D
S
SLGW
Q
A
T
E
R
MN
ISVY
VDNLFD
R
R
Y
------
R
T
Y
G
YMN
G
SS
A
VA
QV
N
M--
-
-
-
-
-
G
--
RT
--
V
GI
NT
fig|216592.3.peg.2309
Escherichia coli 042 (19-668/673)
I
A
N
A
QT
S
Q
---QD
ES
TLVVTA
-
S
K
QS
SR
S
A
S
AN
N
VSS
-------------
TV
V
S
APEL
S
D
A
G
V
T
ASD
K
LP
R
V
L
PG
L
N
I
---
EN
S
GN
ML
F
S
T
-----
-
I
S
L
RG
VSSA
Q
DF
YNPAVTL
Y
V
DG
V
P
QL
S
T
N
TI
----
QAL
T
D
-
--
---------
V
Q
S
VE
L
LRGP
Q
GT
L
YG
K
SA
Q
GG
I
INI
V
T
Q
QP
DSTPR
G
YI
E
G
G
V
S
S
RD
S
Y------
R
SK
F
N
L
S
GPI
-
Q
D
GL--
-
LYG
SVT
LLRQ
V
DD
GDM
IN
P
AT
G
SDDLG
---------
GT
R
AS
I
G
N
-
-----
V
K
LRL
AP
--
-
-----
-
------
-
-
-
---
--
----
D
---------------
--
-
--
--
--
-
-
-
-
-
---
-
--
--
-
---
D
QP
W
E
M
G
F
A
A
S
-----
--
-----------
RE
C
T
R
AT
QD
----
A
YV
G
WNDIK
G
RKLSISDG
S
PDPYMRR
C
T
DS
Q
TLS
GKY
T
T
D
D
WVFNL
I
S
AWQ
Q
Q
HYSR
TF
PS
GS
LI
--
V
N
M
P
Q
R
WNQ
D
V
Q
ELRAA
T
LGD
A
RTV
D
M
---
---
V
--
F
GL
Y
R
QN
TREKLNSAYDMPTMPYLS
S
T
G
Y
TT
AET
L
A
A
Y
S
DL
T
WH
LTD
R
F
D
I
G
GG
V
RF
S
-
H
DKSST
Q
YH
GSM-LGNPF
GD
Q
G
KSND
D
QVL
G
-
-
--
----------------
-
QL
S
A
G
Y
M
LT
D
D
WR
V
Y
T
R
V
A
QGYK
P
S
G
Y
N
IV
P
--
T
AG
----LDAK
P
F
V
AEKSIN
Y
E
L
GT
R
YE
TA
D
V
-
T
L
QA
AT
F
YT
H
T
KD
M
QL
Y
S
G
P
V
GM
-
K
T
--
--
----
L
SN
A
GKA
D
AT
G
V
E
L
E
AKWRFA
P
----
GWS
W
DI
NG
N
V
---
I
R
S
E
F
T
----
N
D
SELYH
G
N
R
V
P
FV
P
R
Y
GAG
S
SVN-
--
--
-
-
-
-
G
VID
T
R
YG
ALM
P
RLA
V
N
L
V
G
PHYFD
G
DNQLRQ
G
T
Y
ATL
D
S
SLGW
Q
A
T
E
R
MN
ISVY
VDNLFD
R
R
Y
------
R
T
Y
G
YMN
G
SS
A
VA
QV
N
M--
-
-
-
-
-
G
--
RT
--
V
GI
NT
fig|316401.4.peg.2383
Escherichia coli ETEC H10407 (19-668/673)
I
A
N
A
QT
S
Q
---QD
ES
TLVVTA
-
S
K
QS
SR
S
A
S
AN
N
VSS
-------------
TV
V
S
APEL
S
D
A
G
V
T
ASD
K
LP
R
V
L
PG
L
N
I
---
EN
S
GN
ML
F
S
T
-----
-
I
S
L
RG
VSSA
Q
DF
YNPAVTL
Y
V
DG
V
P
QL
S
T
N
TI
----
QAL
T
D
-
--
---------
V
Q
S
VE
L
LRGP
Q
GT
L
YG
K
SA
Q
GG
I
INI
V
T
Q
QP
DSTPR
G
YI
E
G
G
V
S
S
RD
S
Y------
R
SK
F
N
L
S
GPI
-
Q
D
GL--
-
LYG
SVT
LLRQ
V
DD
GDM
IN
P
AT
G
SDDLG
---------
GT
R
AS
I
G
N
-
-----
V
K
LRL
AP
--
-
-----
-
------
-
-
-
---
--
----
D
---------------
--
-
--
--
--
-
-
-
-
-
---
-
--
--
-
---
D
QP
W
E
M
G
F
A
A
S
-----
--
-----------
RE
C
T
R
AT
QD
----
A
YV
G
WNDIK
G
RKLSISDG
S
PDPYMRR
C
T
DS
Q
TLS
GKY
T
T
D
D
WVFNL
I
S
AWQ
Q
Q
HYSR
TF
PS
GS
LI
--
V
N
M
P
Q
R
WNQ
D
V
Q
ELRAA
T
LGD
A
RTV
D
M
---
---
V
--
F
GL
Y
R
QN
TREKLNSAYDMPTMPYLS
S
T
G
Y
TT
AET
L
A
A
Y
S
DL
T
WH
LTD
R
F
D
I
G
GG
V
RF
S
-
H
DKSST
Q
YH
GSM-LGNPF
GD
Q
G
KSND
D
QVL
G
-
-
--
----------------
-
QL
S
A
G
Y
M
LT
D
D
WR
V
Y
T
R
V
A
QGYK
P
S
G
Y
N
IV
P
--
T
AG
----LDAK
P
F
V
AEKSIN
Y
E
L
GT
R
YE
TA
D
I
-
T
L
QA
AT
F
YT
H
T
KD
M
QL
Y
S
G
P
V
GM
-
Q
T
--
--
----
L
SN
A
GKA
D
AT
G
V
E
L
E
AKWRFA
P
----
GWS
W
DI
NG
N
V
---
I
R
S
E
F
T
----
N
D
SELYH
G
N
R
V
P
FV
P
R
Y
GAG
S
SVN-
--
--
-
-
-
-
G
VID
T
R
YG
ALM
P
RLA
V
N
L
V
G
PHYFD
G
DNQLRQ
G
T
Y
ATL
D
S
SLGW
Q
A
T
E
R
MN
ISVY
VDNLFD
R
R
Y
------
R
T
Y
G
YMN
G
SS
A
VA
QV
N
M--
-
-
-
-
-
G
--
RT
--
V
GI
NT
fig|656440.3.peg.1938
Escherichia coli TA206 (19-668/673)
I
A
N
A
QT
S
Q
---QD
ES
TLVVTA
-
S
K
QS
SR
S
A
S
AN
N
VSS
-------------
TV
V
S
APEL
S
D
A
G
V
T
ASD
K
LP
R
V
L
PG
L
N
I
---
EN
S
GN
ML
F
S
T
-----
-
I
S
L
RG
VSSA
Q
DF
YNPAVTL
Y
V
DG
V
P
QL
S
T
N
TI
----
QAL
T
D
-
--
---------
V
Q
S
VE
L
LRGP
Q
GT
L
YG
K
SA
Q
GG
I
INI
V
T
Q
QP
DSTPR
G
YI
E
G
G
V
S
S
RD
S
Y------
R
SK
F
N
L
S
GPI
-
Q
D
GL--
-
LYG
SVT
LLRQ
V
DD
GDM
IN
P
AT
G
SDDLG
---------
GT
R
AS
I
G
N
-
-----
V
K
LRL
AP
--
-
-----
-
------
-
-
-
---
--
----
D
---------------
--
-
--
--
--
-
-
-
-
-
---
-
--
--
-
---
D
QP
W
E
M
G
F
A
A
S
-----
--
-----------
RE
C
T
H
AT
QD
----
A
YV
G
WNDIK
G
RKLSISDG
S
PDPYMRR
C
T
DS
Q
TLS
GKY
T
T
D
D
WVFNL
I
S
AWQ
Q
Q
HYSR
TF
PS
GS
LI
--
V
N
M
P
Q
R
WNQ
D
V
Q
ELRAA
T
LGD
A
RTV
D
M
---
---
V
--
F
GL
Y
R
QN
TREKLNSAYDMPTMPYLS
S
T
G
Y
TT
AET
L
A
A
Y
S
DL
T
WH
LTD
R
F
D
I
G
GG
V
RF
S
-
H
DKSST
Q
YH
GSM-LGNPF
GD
Q
G
KSND
D
QVL
G
-
-
--
----------------
-
QL
S
A
G
Y
M
LT
D
D
WR
V
Y
T
R
V
A
QGYK
P
S
G
Y
N
IV
P
--
T
AG
----LDAK
P
F
V
AEKSIN
Y
E
L
GT
R
YE
TA
D
V
-
T
L
QA
AT
F
YT
H
T
KD
M
QL
Y
S
G
P
V
GM
-
Q
T
--
--
----
L
SN
A
GKA
D
AT
G
V
E
L
E
AKWRFA
P
----
GWS
W
DI
NG
N
V
---
I
R
S
E
F
T
----
N
D
SELYH
G
N
R
V
P
FV
P
R
Y
GAG
S
SVN-
--
--
-
-
-
-
G
VID
T
R
YG
ALM
P
RLA
V
N
L
V
G
PHYFD
G
DNQLRQ
G
T
Y
ATL
D
S
SLGW
Q
A
T
E
R
MN
ISVY
VDNLFD
R
R
Y
------
R
T
Y
G
YMN
G
SS
A
VA
QV
N
M--
-
-
-
-
-
G
--
RT
--
V
GI
NT
fig|749550.3.peg.4169
Escherichia coli MS 200-1 (19-668/673)
I
A
N
A
QT
S
Q
---QD
ES
TLVVTA
-
S
K
QS
SR
S
A
S
AN
N
VSS
-------------
TV
V
S
APEL
S
D
A
G
V
T
ASD
K
LP
R
V
L
PG
L
N
I
---
EN
S
GN
ML
F
S
T
-----
-
I
S
L
RG
VSSA
Q
DF
YNPAVTL
Y
V
DG
V
P
QL
S
I
N
TI
----
QAL
T
D
-
--
---------
V
Q
S
VE
L
LRGP
Q
GT
L
YG
K
SA
Q
GG
I
INI
V
T
Q
QP
DSTPR
G
YI
E
G
G
V
S
S
RD
S
Y------
R
SK
F
N
L
S
GPI
-
Q
D
GL--
-
LYG
SVT
LLRQ
V
DD
GDM
IN
P
AT
G
SDDLG
---------
GT
R
AS
I
G
N
-
-----
V
K
LRL
AP
--
-
-----
-
------
-
-
-
---
--
----
D
---------------
--
-
--
--
--
-
-
-
-
-
---
-
--
--
-
---
D
QP
W
E
M
G
F
A
A
S
-----
--
-----------
RE
C
T
R
AT
QD
----
A
YV
G
WNDIK
G
RKLSISDG
S
PDPYMRR
C
T
DS
Q
TLS
GKY
T
T
D
D
WVFNL
I
S
AWQ
Q
Q
HYSR
TF
PS
GS
LI
--
V
N
M
P
Q
R
WNQ
D
V
Q
ELRAA
T
LGD
A
RTV
D
M
---
---
V
--
F
GL
Y
R
QN
TREKLNSAYDMPTMPYLS
S
T
G
Y
TT
AET
L
A
A
Y
S
DL
T
WH
LTD
R
F
D
I
G
GG
V
RF
S
-
H
DKSST
Q
YH
GSM-LGNPF
GD
Q
G
KSND
D
QVL
G
-
-
--
----------------
-
QL
S
A
G
Y
M
LT
D
D
WR
V
Y
T
R
V
A
QGYK
P
S
G
Y
N
IV
P
--
T
AG
----LDAK
P
F
V
AEKSIN
Y
E
L
GT
R
YE
TA
D
V
-
T
L
QA
AT
F
YT
H
T
KD
M
QL
Y
S
G
P
V
GM
-
Q
T
--
--
----
L
SN
A
GKA
D
AT
G
V
E
L
E
AKWRFA
P
----
GWS
W
DI
NG
N
V
---
I
R
S
E
F
T
----
N
D
SELYH
G
N
R
V
P
FV
P
R
Y
GAG
S
SVN-
--
--
-
-
-
-
G
VID
T
R
YG
ALM
P
RLA
V
N
L
V
G
PHYFD
G
DNQLRQ
G
T
Y
ATL
D
S
SLGW
Q
A
T
E
R
MN
ISVY
VDNLFD
R
R
Y
------
R
T
Y
G
YMN
G
SS
A
VA
QV
N
M--
-
-
-
-
-
G
--
RT
--
V
GI
NT
fig|585057.4.peg.1125
Escherichia coli IAI39 (19-668/673)
I
A
N
A
QT
S
Q
---QD
ES
TLVVTA
-
S
K
QS
SR
S
A
S
AN
N
VSS
-------------
TV
V
S
APEL
S
D
A
G
V
T
ASD
K
LP
R
V
L
PG
L
N
I
---
EN
S
GN
ML
F
S
T
-----
-
I
S
L
RG
VSSA
Q
DF
YNPAVTL
Y
V
DG
V
P
QL
S
T
N
TI
----
QAL
T
D
-
--
---------
V
Q
S
VE
L
LRGP
Q
GT
L
YG
K
SA
Q
GG
I
INI
V
T
Q
QP
DSTPR
G
YI
E
G
G
V
S
S
RD
S
Y------
R
SK
F
N
L
S
GPI
-
Q
D
GL--
-
LYG
SVT
LLRQ
V
DD
GDM
IN
P
AT
G
SDDLG
---------
GT
R
AS
I
G
N
-
-----
V
K
LRL
AP
--
-
-----
-
------
-
-
-
---
--
----
D
---------------
--
-
--
--
--
-
-
-
-
-
---
-
--
--
-
---
D
QP
W
E
M
G
F
A
A
S
-----
--
-----------
RE
C
T
R
AT
QD
----
A
YV
G
WNDIK
G
RKLSISDG
S
PDPYMRR
C
T
DS
Q
TLS
GKY
T
T
D
D
WVFNL
I
S
AWQ
Q
Q
HYSR
TF
PS
GS
LI
--
V
N
M
P
Q
R
WNQ
D
V
Q
ELRAA
T
LGD
A
RTV
D
M
---
---
V
--
F
GL
Y
R
QN
TREKLNSAYDMPTMPYLS
S
T
G
Y
TT
AET
L
A
A
Y
S
DL
T
WH
LTD
R
F
D
I
G
GG
V
RF
S
-
H
DKSST
Q
YH
GSM-LGNPF
GD
Q
G
KSND
D
QVL
G
-
-
--
----------------
-
QL
S
A
G
Y
M
LT
D
D
WR
V
Y
T
R
V
A
QGYK
P
S
G
Y
N
IV
P
--
T
AG
----LDAK
P
F
V
AEKSIN
Y
E
L
GT
R
YE
TA
D
V
-
T
L
QA
AT
F
YT
H
T
KD
M
QL
Y
S
G
P
V
GM
-
Q
T
--
--
----
L
SN
A
GKA
D
AT
G
V
E
L
E
AKWRFA
P
----
GWS
W
DI
NG
N
V
---
I
R
S
E
F
T
----
S
D
SELYH
G
N
R
V
P
FV
P
R
Y
GAG
S
SVN-
--
--
-
-
-
-
G
VID
T
R
YG
ALM
P
RLA
V
N
L
V
G
PHYFD
G
DNQLRQ
G
T
Y
ATL
D
S
SLGW
Q
A
T
E
R
MN
IFVY
VDNLFD
R
R
Y
------
R
T
Y
G
YMN
G
SS
A
VA
QV
N
M--
-
-
-
-
-
G
--
RT
--
V
GI
NT
fig|585057.6.peg.1121
Escherichia coli IAI39 (19-668/673)
I
A
N
A
QT
S
Q
---QD
ES
TLVVTA
-
S
K
QS
SR
S
A
S
AN
N
VSS
-------------
TV
V
S
APEL
S
D
A
G
V
T
ASD
K
LP
R
V
L
PG
L
N
I
---
EN
S
GN
ML
F
S
T
-----
-
I
S
L
RG
VSSA
Q
DF
YNPAVTL
Y
V
DG
V
P
QL
S
T
N
TI
----
QAL
T
D
-
--
---------
V
Q
S
VE
L
LRGP
Q
GT
L
YG
K
SA
Q
GG
I
INI
V
T
Q
QP
DSTPR
G
YI
E
G
G
V
S
S
RD
S
Y------
R
SK
F
N
L
S
GPI
-
Q
D
GL--
-
LYG
SVT
LLRQ
V
DD
GDM
IN
P
AT
G
SDDLG
---------
GT
R
AS
I
G
N
-
-----
V
K
LRL
AP
--
-
-----
-
------
-
-
-
---
--
----
D
---------------
--
-
--
--
--
-
-
-
-
-
---
-
--
--
-
---
D
QP
W
E
M
G
F
A
A
S
-----
--
-----------
RE
C
T
R
AT
QD
----
A
YV
G
WNDIK
G
RKLSISDG
S
PDPYMRR
C
T
DS
Q
TLS
GKY
T
T
D
D
WVFNL
I
S
AWQ
Q
Q
HYSR
TF
PS
GS
LI
--
V
N
M
P
Q
R
WNQ
D
V
Q
ELRAA
T
LGD
A
RTV
D
M
---
---
V
--
F
GL
Y
R
QN
TREKLNSAYDMPTMPYLS
S
T
G
Y
TT
AET
L
A
A
Y
S
DL
T
WH
LTD
R
F
D
I
G
GG
V
RF
S
-
H
DKSST
Q
YH
GSM-LGNPF
GD
Q
G
KSND
D
QVL
G
-
-
--
----------------
-
QL
S
A
G
Y
M
LT
D
D
WR
V
Y
T
R
V
A
QGYK
P
S
G
Y
N
IV
P
--
T
AG
----LDAK
P
F
V
AEKSIN
Y
E
L
GT
R
YE
TA
D
V
-
T
L
QA
AT
F
YT
H
T
KD
M
QL
Y
S
G
P
V
GM
-
Q
T
--
--
----
L
SN
A
GKA
D
AT
G
V
E
L
E
AKWRFA
P
----
GWS
W
DI
NG
N
V
---
I
R
S
E
F
T
----
S
D
SELYH
G
N
R
V
P
FV
P
R
Y
GAG
S
SVN-
--
--
-
-
-
-
G
VID
T
R
YG
ALM
P
RLA
V
N
L
V
G
PHYFD
G
DNQLRQ
G
T
Y
ATL
D
S
SLGW
Q
A
T
E
R
MN
IFVY
VDNLFD
R
R
Y
------
R
T
Y
G
YMN
G
SS
A
VA
QV
N
M--
-
-
-
-
-
G
--
RT
--
V
GI
NT
fig|656393.3.peg.2962
Escherichia coli H299 (19-668/673)
I
A
N
A
QT
S
Q
---QD
ES
TLVVTA
-
S
K
QS
SR
S
A
S
AN
N
VSS
-------------
TV
V
S
APEL
S
D
A
G
V
T
ASD
K
LP
R
V
L
PG
L
N
I
---
EN
S
GN
ML
F
S
T
-----
-
I
S
L
RG
VSSA
Q
DF
YNPAVTL
Y
V
DG
V
P
QL
S
T
N
TI
----
QAL
T
D
-
--
---------
V
Q
S
VE
L
LRGP
Q
GT
L
YG
K
SA
Q
GG
I
INI
V
T
Q
QP
DSTPR
G
YI
E
G
G
V
S
S
RD
S
Y------
R
SK
F
N
L
S
GPI
-
Q
D
GL--
-
LYG
SVT
LLRQ
V
DD
GDM
IN
P
AT
G
SDDLG
---------
GT
R
AS
I
G
N
-
-----
V
K
LRL
AP
--
-
-----
-
------
-
-
-
---
--
----
D
---------------
--
-
--
--
--
-
-
-
-
-
---
-
--
--
-
---
D
QP
W
E
M
G
F
A
A
S
-----
--
-----------
RE
C
T
R
AT
QD
----
A
YV
G
WNDIK
G
RKLSISDG
S
PDPYMRR
C
T
DS
Q
TLS
GKY
T
T
D
D
WVFNL
I
S
AWQ
Q
Q
HYSR
TF
PS
GS
LI
--
V
N
M
P
Q
R
WNQ
D
V
Q
ELRAA
T
LGD
A
RTV
D
M
---
---
V
--
F
GL
Y
R
QN
TREKLNSAYDMPTMPYLS
S
T
G
Y
TT
AET
L
A
A
Y
S
DL
T
WH
LTD
R
F
D
I
G
GG
V
RF
S
-
H
DKSST
Q
YH
GSM-LGNPF
GD
Q
G
KSND
D
QVL
G
-
-
--
----------------
-
QL
S
A
G
Y
M
LT
D
D
WR
V
Y
T
R
V
A
QGYK
P
S
G
Y
N
IV
P
--
T
AG
----LDAK
P
F
V
AEKSIN
Y
E
L
GT
R
YE
TA
D
V
-
T
L
QA
AT
F
YT
H
T
KD
M
QL
Y
S
G
P
V
GM
-
Q
T
--
--
----
L
SN
A
GKA
D
AT
G
V
E
L
E
AKWRFA
P
----
GWS
W
DI
NG
N
V
---
I
R
S
E
F
T
----
N
D
SELYH
D
N
R
V
P
FV
P
R
Y
GAG
S
SVN-
--
--
-
-
-
-
G
VID
T
R
YG
ALM
P
RLA
V
N
L
V
G
PHYFD
G
DNQLRQ
G
T
Y
ATL
D
S
SLGW
Q
A
T
E
R
MN
ISVY
VDNLFD
R
R
Y
------
R
T
Y
G
YMN
G
SS
A
VA
QV
N
M--
-
-
-
-
-
G
--
RT
--
V
GI
NT
fig|573235.3.peg.2920
Escherichia coli O26:H11 str. 11368 (19-668/673)
I
A
N
A
QT
S
Q
---QD
ES
TLVVTA
-
S
K
QS
SR
S
A
S
AN
N
VSS
-------------
TV
V
S
APEL
S
D
A
G
V
T
ASD
K
LP
R
V
L
PG
L
N
I
---
EN
S
GN
ML
F
S
T
-----
-
I
S
L
RG
VSSA
Q
DF
YNPAVTL
Y
V
DG
V
P
QL
S
T
N
TI
----
QAL
T
D
-
--
---------
V
Q
S
VE
L
LRGP
Q
GT
L
YG
K
SA
Q
GG
I
INI
V
T
Q
QP
DSTPR
G
YI
E
G
G
V
S
S
RD
S
Y------
R
SK
F
N
L
S
GPI
-
E
D
GL--
-
LYG
SVT
LLRQ
V
DD
GDM
IN
P
AT
G
SDDLG
---------
GT
R
AS
I
G
N
-
-----
V
K
LRL
AP
--
-
-----
-
------
-
-
-
---
--
----
D
---------------
--
-
--
--
--
-
-
-
-
-
---
-
--
--
-
---
D
QP
W
E
M
G
F
A
A
S
-----
--
-----------
RE
C
T
R
AT
QD
----
A
YV
G
WNDIK
G
RKLSISDG
S
PDPYMRR
C
T
DS
Q
TLS
GKY
T
T
D
D
WVFNL
I
S
AWQ
Q
Q
HYSR
TF
PS
GS
LI
--
V
N
M
P
Q
R
WNQ
D
V
Q
ELRAA
T
LGD
A
RTV
D
M
---
---
V
--
F
GL
Y
R
QN
TREKLNSAYDMPTMPYLS
S
T
G
Y
TT
AET
L
A
A
Y
S
DL
T
WH
LTD
R
F
D
I
G
GG
V
RF
S
-
H
DKSST
Q
YH
GSM-LGNPF
GD
Q
G
KSND
D
QVL
G
-
-
--
----------------
-
QL
S
A
G
Y
M
LT
D
D
WR
V
Y
T
R
V
A
QGYK
P
S
G
Y
N
IV
P
--
T
AG
----LDAK
P
F
V
AEKSIN
Y
E
L
GT
R
YE
TA
D
V
-
T
L
QA
AT
F
YT
H
T
KD
M
QL
Y
S
G
P
D
GM
-
Q
T
--
--
----
L
SN
A
GKA
D
AT
G
V
E
L
E
AKWRFA
P
----
GWS
W
DI
NG
N
V
---
I
R
S
E
F
T
----
N
D
SELYH
G
N
R
V
P
FV
P
R
Y
GAG
S
SVN-
--
--
-
-
-
-
G
VID
T
R
YG
ALM
P
RLA
V
N
L
V
G
PHYFD
G
DNQLRQ
G
T
Y
ATL
D
S
SLGW
Q
A
T
E
R
MN
ISVY
VDNLFD
R
R
Y
------
R
T
Y
G
YMN
G
SS
A
VA
QV
N
M--
-
-
-
-
-
G
--
RT
--
V
GI
NT
Consen1
Primary consensus
mNkkiHSLtllvnL
-
iyGva
--
a
a
td
ddTlVVtA
-
s
qsl
-
Ap
s
-------------
Tv
s
kd
gat
d
r
mPGvn
---
tGNst
g
-----
I
iRG
n
------
iyiDG
p
s
nsv
----
rDt
---------
e
vEvlrGP
gt
YG
sA
gG
iNiitkqp
g
d
g
na
s
R
fsltgpi
-
gD
rLyg
--
kt
dd
in
--
g
---------
agR
v
N
-----
vr
AP
--
s
g
l
-
y
tq
D
---------------
t
--
g
-
t
y
--
---
d
wd
g
t
s
eh
-----------
tr
sR
qd
----
a
G
-----
G
s
d
ds
tls
nt
d
l
--
nQt
tf
--
--
lt
g
ewnqq
q
n
l
n
---
i
--
Gl
r
------------------
s
y
aetfa
ya
t
lTd
f
v
gGlRfd
-
h
nyh
Gd
g
t
G
a
----------------
ka
alY
lt
n
-
Yi
ya
p
G
n
a
--
aG
dfkaeksin
EiGtefk
d
-
L
at
fr
d
nkie
g
v
-
Qn
gt
----
sn
gKa
veG
E
s
P
----
W
ng
y
---
e
k
T
----
d
gdrlp
Pey
s
qa
d
s
g
t
yG
p
-
n
kG
g
g
-
Y
d
slgw
vtknls
VdNLFD
r
------
t
g
ganyvA
n
y
-
pG
--
RT
m
NtHF
Consen2
Secondary consensus
i
rqf
affag
gci
itsp
q
q
es
i
e
a
pnsr
s
n
kfsrpvadttrtm
i
a
sn
vvr
k
lg
ffa
ml
s
rgnnr
q
ynpavtllv
-
d
gtirqgw
t
-
dtswvppem
q
i
lik
aa
g
t
v
mvsqkg
-
e
y
s
h
l
v
qvl
q
-
nv
llrq
a
-
--
at
-
agtyattlpgt
i
dingv
-
k
lq
-
-
-
n
-
--
ggiptiglpgysaps
-
ln
-
v
-
-
ny
ltwn
ye
s
a
t
--
dindnttirntre
t
e
-
ylmtg
wndik
a
c
nd
mwh
t
-
-
i
awq
q
--
gs
hdv
p
rftr
m
t
a
d
yhp
vhp
v
a
treklnsaydmptmpyls
n
tdils
fs
n
i
r
t
p
lsh
-
qws
g
-
d
-
spvttvdtaksgnlvn
ql
sg
tn
d
v
t
vs
-
g
pla
s
plvpqtant
l
l
g
r
va
yt
t
m
y
-
-
g
t
--
dlyq
dq
p
k
at
e
vse
ii
vmlk
e
ikng
-
s
svs
rh
l
--
-
-
q
r
i
-
vm
v
p
pt
g
katy
an
r
y
-
wragna
-
-
-
ai
g
-
y
-
ep
m
Consensus 1
(when a gap)
Conservative difference
Consensus 2
(when a gap)
Nonconservative diff.
Other character