┌─ Escherichia coli H299   
                                                  ┌┴─ Escherichia coli M718   
                                                ┌─┴─┬───── Escherichia coli (1-50/62) E24377A   
┌───────────────────────────────────────────────┤   └─ Escherichia coli MS 185-1   
│                                               └─ Escherichia coli MS 119-7   
│                                                                   ┌─ Escherichia coli 042   
│                                                                   ├─ Escherichia coli 1827-70   
│                                                                   ├─ Escherichia coli 536   
│                                                                   ├─ Escherichia coli 83972   
│                                                                   ├─ Escherichia coli APEC O1   
│                                                                   ├─ Escherichia coli B str. REL606   
│                                                                   ├─ Escherichia coli (DE3) BL21(DE3)   
│                                                                   ├─ Escherichia coli CFT073   
│                                                                   ├─ Escherichia coli ED1a   
│                                                                   ├─ Escherichia coli F11   
│                                                                   ├─ Escherichia coli FVEC1412   
│                                                                   ├─ Escherichia coli HS   
│                                                                   ├─ Escherichia coli K12   
│                                                                   ├─ Escherichia coli MS 116-1   
│                                                                   ├─ Escherichia coli MS 175-1   
│                                                                   ├─ Escherichia coli MS 187-1   
│                                                                   ├─ Escherichia coli MS 198-1   
│                                                                   ├─ Escherichia coli MS 45-1   
│                                                                   ├─ Escherichia coli O83:H1 str. NRG 857C   
│                                                                   ├─ Escherichia coli S88   
│                                                                   ├─ Escherichia coli TA206   
│                                                                   ├─ Escherichia coli UM146   
│                                                                   ├─ Escherichia coli UTI89   
│                                                                   ├─ Escherichia coli W3110   
│                                                                   ├─ Escherichia coli str. K-12 substr. DH10B   
│                                                                  ┌┼─ Escherichia coli str. K-12 substr. MG1655   
│                                                                  │├─ Escherichia coli str. K-12 substr. MG1655   
│                                                                  │├─ Escherichia coli WV_060327   
│                                                                  │├─ Escherichia coli UTI89   
│                                                                  │├─ Escherichia coli UMN026   
│                                                                  │├─ Escherichia coli TA280   
│                                                                  │├─ Escherichia coli TA143   
│                                                                  │├─ Escherichia coli OP50   
│                                                                  │├─ Escherichia coli NC101   
│                                                                  │├─ Escherichia coli MS 200-1   
│                                                                  │├─ Escherichia coli MS 196-1   
│                                                                  │├─ Escherichia coli MS 185-1   
│                                                                  │├─ Escherichia coli MS 146-1   
│                                                                  │├─ Escherichia coli MS 115-1   
│                                                                ┌─┤├─ Escherichia coli IHE3034   
│                                                                │ │├─ Escherichia coli H736   
│                                                                │ │├─ Escherichia coli FVEC1302   
│                                                                │ │├─ Escherichia coli ED1a   
│                                                                │ │├─ Escherichia coli DH1   
│                                                                │ │├─ Escherichia coli BW2952   
│                                                                │ │├─ Escherichia coli BL21   
│                                                                │ │├─ Escherichia coli ATCC 8739   
│                                                                │ │├─ Escherichia coli ABU 83972   
│                                                               ┌┤ │├─ Escherichia coli 536   
│                                                               ││ │├─ Escherichia coli 2362-75   
│                                                               ││ │└─ Escherichia coli 101-1   
│                                                               ││ │┌── Escherichia coli 53638   
┤                                                               ││ └┤ ┌─ Escherichia coli IAI39   
│                                                               ││  └─┼─ Escherichia coli SE15   
│                       ┌───────────────────────────────────────┤│    ├─ Escherichia coli M605   
│                       │                                       ││    └─ Escherichia coli IAI39   
│                       │                                       │└┬─ Escherichia coli SMS-3-5   
│                       │                                       │ └─ Escherichia coli MS 21-1   
│   ┌───────────────────┤                                       │ ┌─ Escherichia coli (1-57/78) W   
│   │                   │                                       └─┼─ Escherichia coli (1-57/78) W   
│   │                   │                                         └─ Escherichia coli (1-57/78) KO11   
│   │                   └─────────────────────────────────────┬─ Escherichia coli MS 200-1   
│   │                                                         └┬─ Escherichia coli MS 21-1   
│   │                                                          └─ Escherichia coli MS 196-1   
│   │                                     ┌─ Escherichia coli (46-95/95) 1044A   
│   │                                     ├─ Escherichia coli (46-95/95) 1212A   
│   │                                     ├─ Escherichia coli (46-95/95) M605   
│   │                                     ├─ Escherichia coli (46-95/95) O157:H7 EDL933   
│   │                                     ├─ Escherichia coli (46-95/95) O157:H7 str. EC4042   
│   │                                     ├─ Escherichia coli (46-95/95) O157:H7 str. EC4076   
│   │                                     ├─ Escherichia coli (46-95/95) O157:H7 str. EC4115   
│   │                                     ├─ Escherichia coli (46-95/95) O157:H7 str. EC4206   
│   │                                     ├─ Escherichia coli (46-95/95) O157:H7 str. EC4501   
│   │                                     ├─ Escherichia coli (46-95/95) O157:H7 str. EC869   
│   │                                     ├─ Escherichia coli (46-95/95) O157:H7 str. FRIK966   
│   │                                     ├─ Escherichia coli (46-95/95) O157:H7 str. TW14359   
│   │                                     ├─ Escherichia coli (46-95/95) O55:H7 str. CB9615   
│   │                                     ├─ fig|1040638.4.peg.2642 O104:H4 str. LB226692   
│   │                                     ├─ Escherichia coli 042   
│   │                                     ├─ Escherichia coli 536   
│   │                                     ├─ Escherichia coli 55989   
│   │                                     ├─ Escherichia coli APEC O1   
│   │                                     ├─ Escherichia coli B185   
│   │                                     ├─ Escherichia coli E110019   
│   │                                     ├─ Escherichia coli E2348/69   
│   │                                     ├─ Escherichia coli EC4100B   
│   │                                     ├─ Escherichia coli ED1a   
│   │                                     ├─ Escherichia coli FVEC1302   
│   │                                     ├─ Escherichia coli H299   
│   │                                     ├─ Escherichia coli IAI1   
│   │                                     ├─ Escherichia coli M718   
│   │                                     ├─ Escherichia coli MS 115-1   
│   │                                     ├─ Escherichia coli MS 124-1   
│   │                                     ├─ Escherichia coli MS 185-1   
│   │                                     ├─ Escherichia coli MS 200-1   
│   │                                     ├─ Escherichia coli MS 69-1   
│   │                                     ├─ Escherichia coli MS 84-1   
│   │                                     ├─ Escherichia coli O127:H6 str. E2348/69   
│   │                                     ├─ Escherichia coli O157:H7 EDL933   
│   │                                     ├─ Escherichia coli S88   
│   │                                     ├─ Escherichia coli TA143   
│   │                                     ├─ Escherichia coli UM146   
│   │                                     ├─ Escherichia coli UTI89   
│   │                                   ┌─┼─ Escherichia coli WV_060327   
│   │                                   │ ├─ Escherichia coli UTI89   
│   │                                   │ ├─ Escherichia coli UMN026   
└───┤                                   │ ├─ Escherichia coli TA271   
    │                                   │ ├─ Escherichia coli SE11   
    │                                   │ ├─ Escherichia coli O26:H11 str. 11368   
    │                                   │ ├─ Escherichia coli O157:H7   
    │                                   │ ├─ Escherichia coli O111:H- str. 11128   
    │                                   │ ├─ Escherichia coli MS 78-1   
    │                                   │ ├─ Escherichia coli MS 45-1   
    │                                   │ ├─ Escherichia coli MS 198-1   
    │                                   │ ├─ Escherichia coli MS 182-1   
    │                                   │ ├─ Escherichia coli MS 119-7   
    │                                   │ ├─ Escherichia coli MS 107-1   
    │                                   │ ├─ Escherichia coli IAI1   
    │                                   │ ├─ Escherichia coli H591   
    │                                   │ ├─ Escherichia coli FVEC1412   
    │                                   │ ├─ Escherichia coli F11   
    │                                   │ ├─ Escherichia coli ED1a   
    │                                   │ ├─ Escherichia coli E24377A   
    │                                   │ ├─ Escherichia coli E22   
    │                                   │ ├─ Escherichia coli CFT073   
    │                                   │ ├─ Escherichia coli B088   
    │                                   │ ├─ Escherichia coli ABU 83972   
    │                              ┌────┤ ├─ Escherichia coli 55989   
    │                              │    │ ├─ Escherichia coli 536   
    │                              │    │ ├─ Escherichia coli 042   
    │                              │    │ ├─ Escherichia coli (46-95/95) SE15   
    │                              │    │ ├─ Escherichia coli (46-95/95) O157:H7 str. TW14588   
    │                              │    │ ├─ Escherichia coli (46-95/95) O157:H7 str. Sakai   
    │                              │    │ ├─ Escherichia coli (46-95/95) O157:H7 str. FRIK2000   
    │                              │    │ ├─ Escherichia coli (46-95/95) O157:H7 str. EC508   
    │                              │    │ ├─ Escherichia coli (46-95/95) O157:H7 str. EC4486   
    │                              │    │ ├─ Escherichia coli (46-95/95) O157:H7 str. EC4196   
    │                              │    │ ├─ Escherichia coli (46-95/95) O157:H7 str. EC4113   
    │                              │    │ ├─ Escherichia coli (46-95/95) O157:H7 str. EC4045   
    │                              │    │ ├─ Escherichia coli (46-95/95) O157:H7 str. EC4024   
    │                              │    │ ├─ Escherichia coli (46-95/95) NC101   
    │                              │    │ ├─ Escherichia coli (46-95/95) 536A   
    │                              │    │ └─ Escherichia coli (46-95/95) 1125A   
    │                              │    │┌─ Escherichia coli B str. REL606   
    │                              │    │├─ Escherichia coli B7A   
    │                              │    │├─ Escherichia coli (DE3) BL21(DE3)   
    │                              │    │├─ Escherichia coli IAI39   
    │                              │    │├─ Escherichia coli MS 145-7   
    │                              │    │├─ Escherichia coli OP50   
    │                              │    │├─ Escherichia coli TA280   
    │                              │    └┼─ Escherichia coli W   
    │                              │     ├─ Escherichia coli SMS-3-5   
    │                              │     ├─ Escherichia coli MS 21-1   
    │                              │     ├─ Escherichia coli KO11   
    │                              │     ├─ Escherichia coli H736   
    └──────────────────────────────┤     ├─ Escherichia coli BL21   
                                   │     ├─ Escherichia coli B354   
                                   │     └─ Escherichia coli 101-1   
                                   │                ┌─ Escherichia coli B354   
                                   │              ┌─┼─ Escherichia coli TA280   
                                   │              │ └─ Escherichia coli MS 69-1   
                                   │              │  ┌─ Escherichia coli IAI39   
                                   │              │┌─┴─ Escherichia coli IAI39   
                                   │              ││     ┌─ Escherichia coli (34-83/83) ATCC 8739   
                                   │              ││     ├─ Escherichia coli (34-83/83) str. K-12 substr. DH10B   
                                   │              ││     ├─ Escherichia coli (34-83/83) E2348/69   
                                   │              ││     ├─ Escherichia coli 101-1   
                                   │              ││     ├─ Escherichia coli 2362-75   
                                   │              ││     ├─ Escherichia coli ATCC 8739   
                                   │              ││     ├─ Escherichia coli B354   
                                   │              ││     ├─ Escherichia coli (DE3) BL21(DE3)   
                                   │              ││     ├─ Escherichia coli DH1   
                                   │              ││     ├─ Escherichia coli ETEC H10407   
                                   │              ││     ├─ Escherichia coli HS   
                                   │              ││     ├─ Escherichia coli MS 116-1   
                                   │              ││     ├─ Escherichia coli MS 146-1   
                                   │              ││     ├─ Escherichia coli MS 187-1   
                                   │              ││     ├─ Escherichia coli MS 78-1   
                                   │              ││     ├─ Escherichia coli O111:H- str. 11128   
                                   │              ││     ├─ Escherichia coli OP50   
                                   │              ││     ├─ Escherichia coli W3110   
                                   │              ││     ├─ Escherichia coli str. K-12 substr. DH10B   
                                   │              ││    ┌┼─ Escherichia coli str. K-12 substr. MG1655   
                                   │              ││    │├─ Escherichia coli str. K-12 substr. MG1655   
                                   └──────────────┤│    │├─ Escherichia coli str. K-12 substr. DH10B   
                                                  ││    │├─ Escherichia coli SE15   
                                                  ││    │├─ Escherichia coli O26:H11 str. 11368   
                                                  ││    │├─ Escherichia coli MS 84-1   
                                                  ││    │├─ Escherichia coli MS 196-1   
                                                  ││    │├─ Escherichia coli MS 182-1   
                                                  ││    │├─ Escherichia coli MS 124-1   
                                                  ││    │├─ Escherichia coli MS 115-1   
                                                  ││   ┌┤├─ Escherichia coli H736   
                                                  ││   ││├─ Escherichia coli E24377A   
                                                  ││   ││├─ Escherichia coli BW2952   
                                                  ││   ││├─ Escherichia coli BL21   
                                                  ││   ││├─ Escherichia coli B str. REL606   
                                                  ││   ││├─ Escherichia coli 53638   
                                                  ││   ││├─ Escherichia coli 1827-70   
                                                  ││   ││├─ Escherichia coli (34-83/83) O127:H6 str. E2348/69   
                                                  ││ ┌─┤│├─ Escherichia coli (34-83/83) str. K-12 substr. DH10B   
                                                  ││ │ ││└─ Escherichia coli (34-83/83) K12   
                                                  ││ │ │└── Escherichia coli TA143   
                                                  ││ │ │ ┌─── Escherichia coli IAI1   
                                                  ││ │ │ │┌─ fig|1040638.4.peg.5270 O104:H4 str. LB226692   
                                                  ││ │ │ │├─ Escherichia coli 55989   
                                                  ││ │ │ │├─ Escherichia coli B7A   
                                                  ││ │ │ │├─ Escherichia coli E22   
                                                  ││ │ └─┤├─ Escherichia coli H591   
                                                  └┤ │   │├─ Escherichia coli KO11   
                                                   │ │   │├─ Escherichia coli MS 119-7   
                                                   │ │   │├─ Escherichia coli O103:H2 str. 12009   
                                                   │ │   │├─ Escherichia coli TA271   
                                                   │ │   └┼─ Escherichia coli W   
                                                   │┌┤    ├─ Escherichia coli W   
                                                   │││    ├─ Escherichia coli SE11   
                                                   │││    ├─ Escherichia coli MS 145-7   
                                                   │││    ├─ Escherichia coli MS 107-1   
                                                   │││    ├─ Escherichia coli IAI1   
                                                   │││    ├─ Escherichia coli EC4100B   
                                                   │││    ├─ Escherichia coli E110019   
                                                   │││    ├─ Escherichia coli B171   
                                                   │││    ├─ Escherichia coli 55989   
                                                   │││    └─ Escherichia coli (13-62/62) B171   
                                                   │││┌─ fig|1040638.4.peg.5272 O104:H4 str. LB226692   
                                                   ││││ ┌─ Escherichia coli M718   
                                                   ││││ │ ┌─ Escherichia coli (49-98/98) O157:H7 str. EC4486   
                                                   ││└┤ │ ├─ Escherichia coli 1125A   
                                                   ││ │ │ ├─ Escherichia coli 536A   
                                                   ││ │ │ ├─ Escherichia coli O157:H7 EDL933   
                                                   ││ │ │ ├─ Escherichia coli O157:H7 str. EC4042   
                                                   ││ └─┤ ├─ Escherichia coli O157:H7 str. EC4076   
                                                   ││   │ ├─ Escherichia coli O157:H7 str. EC4115   
                                                   ││   │ ├─ Escherichia coli O157:H7 str. EC4206   
                                                   ││   │ ├─ Escherichia coli O157:H7 str. EC4501   
                                                   ││   │ ├─ Escherichia coli O157:H7 str. EC869   
                                                   ││   │ ├─ Escherichia coli O157:H7 str. FRIK966   
                                                   ││   │ ├─ Escherichia coli O157:H7 str. TW14359   
                                                   ││   └─┼─ Escherichia coli O55:H7 str. CB9615   
                                                   ││     ├─ Escherichia coli O157:H7 str. TW14588   
                                                   ││     ├─ Escherichia coli O157:H7 str. Sakai   
                                                   ││     ├─ Escherichia coli O157:H7 str. FRIK2000   
                                                   ││     ├─ Escherichia coli O157:H7 str. EC508   
                                                   ││     ├─ Escherichia coli O157:H7 str. EC4401   
                                                   ││     ├─ Escherichia coli O157:H7 str. EC4196   
                                                   ││     ├─ Escherichia coli O157:H7 str. EC4113   
                                                   ││     ├─ Escherichia coli O157:H7 str. EC4045   
                                                   ││     ├─ Escherichia coli O157:H7 str. EC4024   
                                                   ││     ├─ Escherichia coli O157:H7   
                                                   ││     ├─ Escherichia coli 1212A   
                                                   ││     ├─ Escherichia coli 1044A   
                                                   ││     └─ Escherichia coli (49-98/98) O157:H7 EDL933   
                                                   ││┌─ Escherichia coli (34-83/83) O157:H7   
                                                   ││├─ Escherichia coli (13-62/62) 042   
                                                   ││├─ Escherichia coli 042   
                                                   ││├─ Escherichia coli 1044A   
                                                   ││├─ Escherichia coli 1212A   
                                                   └┤├─ Escherichia coli 536   
                                                    │├─ Escherichia coli 55989   
                                                    │├─ Escherichia coli 83972   
                                                    │├─ Escherichia coli APEC O1   
                                                    │├─ Escherichia coli B185   
                                                    │├─ Escherichia coli CFT073   
                                                    │├─ Escherichia coli E22   
                                                    │├─ Escherichia coli EC4100B   
                                                    │├─ Escherichia coli ED1a   
                                                    │├─ Escherichia coli FVEC1302   
                                                    │├─ Escherichia coli FVEC1302   
                                                    │├─ Escherichia coli FVEC1412   
                                                    │├─ Escherichia coli H299   
                                                    │├─ Escherichia coli H299   
                                                    │├─ Escherichia coli H299   
                                                    │├─ Escherichia coli IAI1   
                                                    │├─ Escherichia coli IHE3034   
                                                    │├─ Escherichia coli M605   
                                                    │├─ Escherichia coli MS 119-7   
                                                    │├─ Escherichia coli MS 185-1   
                                                    │├─ Escherichia coli MS 200-1   
                                                    │├─ Escherichia coli MS 45-1   
                                                    │├─ Escherichia coli O103:H2 str. 12009   
                                                    │├─ Escherichia coli O157:H7 EDL933   
                                                    │├─ Escherichia coli O157:H7 str. EC4042   
                                                    │├─ Escherichia coli O157:H7 str. EC4076   
                                                    │├─ Escherichia coli O157:H7 str. EC4115   
                                                    │├─ Escherichia coli O157:H7 str. EC4206   
                                                    │├─ Escherichia coli O157:H7 str. EC4486   
                                                    │├─ Escherichia coli O157:H7 str. EC508   
                                                    │├─ Escherichia coli O157:H7 str. FRIK2000   
                                                    │├─ Escherichia coli O157:H7 str. Sakai   
                                                    │├─ Escherichia coli O157:H7 str. TW14588   
                                                    │├─ Escherichia coli O55:H7 str. CB9615   
                                                    │├─ Escherichia coli O83:H1 str. NRG 857C   
                                                    │├─ Escherichia coli SE11   
                                                    │├─ Escherichia coli SMS-3-5   
                                                    │├─ Escherichia coli TA206   
                                                    │├─ Escherichia coli TA206   
                                                    │├─ Escherichia coli TA280   
                                                    │├─ Escherichia coli UMN026   
                                                    │├─ Escherichia coli UTI89   
                                                    │├─ Escherichia coli W   
                                                    └┼─ Escherichia coli WV_060327   
                                                     ├─ Escherichia coli W   
                                                     ├─ Escherichia coli UTI89   
                                                     ├─ Escherichia coli UMN026   
                                                     ├─ Escherichia coli UM146   
                                                     ├─ Escherichia coli TA271   
                                                     ├─ Escherichia coli TA206   
                                                     ├─ Escherichia coli TA143   
                                                     ├─ Escherichia coli SE15   
                                                     ├─ Escherichia coli S88   
                                                     ├─ Escherichia coli O83:H1 str. NRG 857C   
                                                     ├─ Escherichia coli O26:H11 str. 11368   
                                                     ├─ Escherichia coli O157:H7 str. TW14359   
                                                     ├─ Escherichia coli O157:H7 str. FRIK966   
                                                     ├─ Escherichia coli O157:H7 str. EC869   
                                                     ├─ Escherichia coli O157:H7 str. EC4501   
                                                     ├─ Escherichia coli O157:H7 str. EC4401   
                                                     ├─ Escherichia coli O157:H7 str. EC4196   
                                                     ├─ Escherichia coli O157:H7 str. EC4113   
                                                     ├─ Escherichia coli O157:H7 str. EC4045   
                                                     ├─ Escherichia coli O157:H7 str. EC4024   
                                                     ├─ Escherichia coli O111:H- str. 11128   
                                                     ├─ Escherichia coli NC101   
                                                     ├─ Escherichia coli MS 21-1   
                                                     ├─ Escherichia coli MS 198-1   
                                                     ├─ Escherichia coli MS 145-7   
                                                     ├─ Escherichia coli MS 107-1   
                                                     ├─ Escherichia coli KO11   
                                                     ├─ Escherichia coli IAI1   
                                                     ├─ Escherichia coli H591   
                                                     ├─ Escherichia coli H299   
                                                     ├─ Escherichia coli H299   
                                                     ├─ Escherichia coli H299   
                                                     ├─ Escherichia coli FVEC1412   
                                                     ├─ Escherichia coli FVEC1302   
                                                     ├─ Escherichia coli F11   
                                                     ├─ Escherichia coli ED1a   
                                                     ├─ Escherichia coli E24377A   
                                                     ├─ Escherichia coli E110019   
                                                     ├─ Escherichia coli B7A   
                                                     ├─ Escherichia coli B171   
                                                     ├─ Escherichia coli ABU 83972   
                                                     ├─ Escherichia coli 55989   
                                                     ├─ Escherichia coli 536A   
                                                     ├─ Escherichia coli 536   
                                                     ├─ Escherichia coli 1125A   
                                                     ├─ Escherichia coli 042   
                                                     ├─ Escherichia coli 042   
                                                     ├─ Escherichia coli (34-83/83) O157:H7 EDL933   
                                                     └─ Escherichia coli (34-83/83) B088   
  
HokE protein (246)
putative membrane permeability altering protein (61)
hypothetical protein (31)
post-segregation killing protein (5)
SrnB (2)
Hok/Gef family protein (2)
conserved domain protein (1)
Protein pndA (1)
Others (6)