fig|1040638.4.peg.5263
Escherichia coli O104:H4 str. LB226692
MIEWIIRR
S
VA
NRF
L
VLMG
A
L
F
L
S
I
W
G
TWT
I
IN
T
PV
D
AL
P
D
L
SD
V
Q
V
I
I
K
T
S
YPG
Q
A
P
Q
I
V
E
N
Q
VT
Y
PLT
TT
M
LS
V
P
G
AK
T
VRG
F
S
QF-
G
DSY
VYV
I
FE
D
GT
D
P
Y
W
A
RS
R
V
L
EY
L
N
Q
V
QGK
LP
A-----
GV
SAELGPDAT
GVG
W
I
YEY
A
LV
D
RSGKHDLA
D
L
R
S
L
Q
DWF
L
KYE
L
K
TIP
D
V
A
E
V
ASV
G
GVVKEY
QV
V
I
D
S
QR
L
A
QYG
I
SLAE
V
KS
A
L
DAS
N
QEAGG
SSI
--
-
-
--ELAEAEYM
V
R
A
SGY
LQT
L
D
D
F
NH
I
V
L
KASE
N
G
VP
V
Y
L
R
DVA
K
V
Q
I
G
P
E
MRRGI
A
EL
NG
E
G
E
V
A
G
GV
V
I
L
RS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSS
L
P
E
GV
E
IVTT
YD
RS
QL
I
DR
A
I
D
N
LSGK
L
L
E
EF
I
V
V
A
V
V
C
A
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
I
V
M
H
F
Q
G
L
N
A
N
I
MSL
G
G
I
A
I
A
V
G
A
M
VD
A
AIV
MI
EN
AH
K
R
L
E
E
WQHQHPDATL
D
NKT
R
WQ
V
IT
D
ASV
EVG
P
AL
FISLLI
I
T
LS
FIP
I
F
T
LE
G
QE
G
R
LFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------L
N
RF
L
IRV---
----
Y
HPLLL
KVL
HWPKTT
L
L
V
A
A
L
SVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TD
K
--
LIMSVPE
V
A
R
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMD
K
II
E
EL
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LST
G
IK
S
PIGIK
V
SGTVLADI
D
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
LE
GGRYIN
V
E
IN
RE
KA
A
R
Y
G
MTV
A
D
V
QLF
V
T
S
T
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DS
P
QA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DIKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YI
D
A
RDRD
M
V
S
V
V
HDLQKAIAEK
V
Q
LK
P
G
TSVA
F
S
G
--
-Q
FE
LL
E
RANHKLK
L
M
VP
M
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAI
E
AE
PSLNNPQTFSE
QKLD
EA
LYH
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
GAGS
E
VMSR
I
A
A
PM
I
GGM
IT
A
P
LL
S
L
F
II
P
AA
Y
K
L
M
WLHRHRVRK
fig|6666666.5357.peg.2328
Escherichia coli TY-2482
MIEWIIRR
S
VA
NRF
L
VLMG
A
L
F
L
S
I
W
G
TWT
I
IN
T
PV
D
AL
P
D
L
SD
V
Q
V
I
I
K
T
S
YPG
Q
A
P
Q
I
V
E
N
Q
VT
Y
PLT
TT
M
LS
V
P
G
AK
T
VRG
F
S
QF-
G
DSY
VYV
I
FE
D
GT
D
P
Y
W
A
RS
R
V
L
EY
L
N
Q
V
QGK
LP
A-----
GV
SAELGPDAT
GVG
W
I
YEY
A
LV
D
RSGKHDLA
D
L
R
S
L
Q
DWF
L
KYE
L
K
TIP
D
V
A
E
V
ASV
G
GVVKEY
QV
V
I
D
S
QR
L
A
QYG
I
SLAE
V
KS
A
L
DAS
N
QEAGG
SSI
--
-
-
--ELAEAEYM
V
R
A
SGY
LQT
L
D
D
F
NH
I
V
L
KASE
N
G
VP
V
Y
L
R
DVA
K
V
Q
I
G
P
E
MRRGI
A
EL
NG
E
G
E
V
A
G
GV
V
I
L
RS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSS
L
P
E
GV
E
IVTT
YD
RS
QL
I
DR
A
I
D
N
LSGK
L
L
E
EF
I
V
V
A
V
V
C
A
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
I
V
M
H
F
Q
G
L
N
A
N
I
MSL
G
G
I
A
I
A
V
G
A
M
VD
A
AIV
MI
EN
AH
K
R
L
E
E
WQHQHPDATL
D
NKT
R
WQ
V
IT
D
ASV
EVG
P
AL
FISLLI
I
T
LS
FIP
I
F
T
LE
G
QE
G
R
LFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------L
N
RF
L
IRV---
----
Y
HPLLL
KVL
HWPKTT
L
L
V
A
A
L
SVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TD
K
--
LIMSVPE
V
A
R
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMD
K
II
E
EL
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LST
G
IK
S
PIGIK
V
SGTVLADI
D
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
LE
GGRYIN
V
E
IN
RE
KA
A
R
Y
G
MTV
A
D
V
QLF
V
T
S
T
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DS
P
QA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DIKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YI
D
A
RDRD
M
V
S
V
V
HDLQKAIAEK
V
Q
LK
P
G
TSVA
F
S
G
--
-Q
FE
LL
E
RANHKLK
L
M
VP
M
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAI
E
AE
PSLNNPQTFSE
QKLD
EA
LYH
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
GAGS
E
VMSR
I
A
A
PM
I
GGM
IT
A
P
LL
S
L
F
II
P
AA
Y
K
L
M
WLHRHRVRK
fig|585055.6.peg.576
Escherichia coli 55989
MIEWIIRR
S
VA
NRF
L
VLMG
A
L
F
L
S
I
W
G
TWT
I
IN
T
PV
D
AL
P
D
L
SD
V
Q
V
I
I
K
T
S
YPG
Q
A
P
Q
I
V
E
N
Q
VT
Y
PLT
TT
M
LS
V
P
G
AK
T
VRG
F
S
QF-
G
DSY
VYV
I
FE
D
GT
D
P
Y
W
A
RS
R
V
L
EY
L
N
Q
V
QGK
LP
A-----
GV
SAELGPDAT
GVG
W
I
YEY
A
LV
D
RSGKHDLA
D
L
R
S
L
Q
DWF
L
KYE
L
K
TIP
D
V
A
E
V
ASV
G
GVVKEY
QV
V
I
DP
QR
L
A
QYG
I
SLAE
V
KS
A
L
DAS
N
QEAGG
SSI
--
-
-
--ELAEAEYM
V
R
A
SGY
LQT
L
D
D
F
NH
I
V
L
KASE
N
G
VP
V
Y
L
R
DVA
K
V
Q
I
G
P
E
MRRGI
A
EL
NG
E
G
E
V
A
G
GV
V
I
L
RS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSS
L
P
E
GV
E
IVTT
YD
RS
QL
I
DR
A
I
D
N
LSGK
L
L
E
EF
I
V
V
A
V
V
C
A
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
I
V
M
H
F
Q
G
L
N
A
N
I
MSL
G
G
I
A
I
A
V
G
A
M
VD
A
AIV
MI
EN
AH
K
R
L
E
E
WQHQHPDATL
D
NKT
R
WQ
V
IT
D
ASV
EVG
P
AL
FISLLI
I
T
LS
FIP
I
F
T
LE
G
QE
G
R
LFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------L
N
RF
L
IRV---
----
Y
HPLLL
KVL
HWPKTT
L
L
V
A
A
L
SVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TD
K
--
LIMSVPE
V
A
R
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMD
K
II
E
EL
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LST
G
IK
S
PIGIK
V
SGTVLADI
D
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
LE
GGRYIN
V
E
IN
RE
KA
A
R
Y
G
MTV
A
D
V
QLF
V
T
S
T
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DS
P
QA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DIKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YI
D
A
RDRD
M
V
S
V
V
HDLQKAIAEK
V
Q
LK
P
G
TSVA
F
S
G
--
-Q
FE
LL
E
RANHKLK
L
M
VP
M
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAI
E
AE
PSLNNPQTFSE
QKLD
EA
LYH
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
GAGS
E
VMSR
I
A
A
PM
I
GGM
IT
A
P
LL
S
L
F
II
P
AA
Y
K
L
M
WLHRHRVRK
fig|585055.8.peg.577
Escherichia coli 55989
MIEWIIRR
S
VA
NRF
L
VLMG
A
L
F
L
S
I
W
G
TWT
I
IN
T
PV
D
AL
P
D
L
SD
V
Q
V
I
I
K
T
S
YPG
Q
A
P
Q
I
V
E
N
Q
VT
Y
PLT
TT
M
LS
V
P
G
AK
T
VRG
F
S
QF-
G
DSY
VYV
I
FE
D
GT
D
P
Y
W
A
RS
R
V
L
EY
L
N
Q
V
QGK
LP
A-----
GV
SAELGPDAT
GVG
W
I
YEY
A
LV
D
RSGKHDLA
D
L
R
S
L
Q
DWF
L
KYE
L
K
TIP
D
V
A
E
V
ASV
G
GVVKEY
QV
V
I
DP
QR
L
A
QYG
I
SLAE
V
KS
A
L
DAS
N
QEAGG
SSI
--
-
-
--ELAEAEYM
V
R
A
SGY
LQT
L
D
D
F
NH
I
V
L
KASE
N
G
VP
V
Y
L
R
DVA
K
V
Q
I
G
P
E
MRRGI
A
EL
NG
E
G
E
V
A
G
GV
V
I
L
RS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSS
L
P
E
GV
E
IVTT
YD
RS
QL
I
DR
A
I
D
N
LSGK
L
L
E
EF
I
V
V
A
V
V
C
A
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
I
V
M
H
F
Q
G
L
N
A
N
I
MSL
G
G
I
A
I
A
V
G
A
M
VD
A
AIV
MI
EN
AH
K
R
L
E
E
WQHQHPDATL
D
NKT
R
WQ
V
IT
D
ASV
EVG
P
AL
FISLLI
I
T
LS
FIP
I
F
T
LE
G
QE
G
R
LFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------L
N
RF
L
IRV---
----
Y
HPLLL
KVL
HWPKTT
L
L
V
A
A
L
SVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TD
K
--
LIMSVPE
V
A
R
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMD
K
II
E
EL
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LST
G
IK
S
PIGIK
V
SGTVLADI
D
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
LE
GGRYIN
V
E
IN
RE
KA
A
R
Y
G
MTV
A
D
V
QLF
V
T
S
T
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DS
P
QA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DIKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YI
D
A
RDRD
M
V
S
V
V
HDLQKAIAEK
V
Q
LK
P
G
TSVA
F
S
G
--
-Q
FE
LL
E
RANHKLK
L
M
VP
M
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAI
E
AE
PSLNNPQTFSE
QKLD
EA
LYH
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
GAGS
E
VMSR
I
A
A
PM
I
GGM
IT
A
P
LL
S
L
F
II
P
AA
Y
K
L
M
WLHRHRVRK
fig|679207.4.peg.2892
Escherichia coli MS 107-1
MIEWIIRR
S
VA
NRF
L
VLMG
A
L
F
L
S
I
W
G
TWT
I
IN
T
PV
D
AL
P
D
L
SD
V
Q
V
I
I
K
T
S
YPG
Q
A
P
Q
I
V
E
N
Q
VT
Y
PLT
TT
M
LS
V
P
G
AK
T
VRG
F
S
QF-
G
DSY
VYV
I
FE
D
GT
D
P
Y
W
A
RS
R
V
L
EY
L
N
Q
V
QGK
LP
A-----
GV
SAELGPDAT
GVG
W
I
YEY
A
LV
D
RSGKHDLA
D
L
R
S
L
Q
DWF
L
KYE
L
K
TIP
D
V
A
E
V
ASV
G
GVVKEY
QV
V
I
DP
QR
L
A
QYG
I
SLAE
V
KS
A
L
DAS
N
QEAGG
SSI
--
-
-
--ELAEAEYM
V
R
A
SGY
LQT
L
D
D
F
NH
I
V
L
KASE
N
G
VP
V
Y
L
R
DVA
K
V
Q
I
G
P
E
MRRGI
A
EL
NG
E
G
E
V
A
G
GV
V
I
L
RS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSS
L
P
E
GV
E
IVTT
YD
RS
QL
I
DR
A
I
D
N
LSGK
L
L
E
EF
I
V
V
A
V
V
C
A
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
I
V
M
H
F
Q
G
L
N
A
N
I
MSL
G
G
I
A
I
A
V
G
A
M
VD
A
AIV
MI
EN
AH
K
R
L
E
E
WQHQHPDATL
D
NKT
R
WQ
V
IT
D
ASV
EVG
P
AL
FISLLI
I
T
LS
FIP
I
F
T
LE
G
QE
G
R
LFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------L
N
RF
L
IRV---
----
Y
HPLLL
KVL
HWPKTT
L
L
V
A
A
L
SVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TD
K
--
LIMSVPE
V
A
R
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMD
K
II
E
EL
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LST
G
IK
S
PIGIK
V
SGTVLADI
D
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
LE
GGRYIN
V
E
IN
RE
KA
A
R
Y
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DS
P
QA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DIKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YI
D
A
RDRD
M
V
S
V
V
HDLQKAIAEK
V
Q
LK
P
G
TSVA
F
S
G
--
-Q
FE
LL
E
RANHKLK
L
M
VP
M
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAI
E
AE
PSLNNPQTFSE
QKLD
EA
LYH
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
GAGS
E
VMSR
I
A
A
PM
I
GGM
IT
A
P
LL
S
L
F
II
P
AA
Y
K
L
M
WLHRHRVRK
fig|216592.1.peg.326
Escherichia coli 042
MIEWIIRR
S
VA
NRF
L
VLMG
A
L
F
L
S
I
W
G
TWT
I
IN
T
PV
D
AL
P
D
L
SD
V
Q
V
I
I
K
T
S
YPG
Q
A
P
Q
I
V
E
N
Q
VT
Y
PLT
TT
M
LS
V
P
G
AK
T
VRG
F
S
QF-
G
DSY
VYV
I
FE
D
GT
D
P
Y
W
A
RS
R
V
L
EY
L
N
Q
V
QGK
LP
A-----
GV
SAELGPDAT
GVG
W
I
YEY
A
LV
D
RSGKHDLA
D
L
R
S
L
Q
DWF
L
KYE
L
K
TIP
D
V
A
E
V
ASV
G
GVVKEY
QV
V
I
DP
QR
L
A
QYG
I
SLAE
V
KS
A
L
DAS
N
QEAGG
SSI
--
-
-
--ELAEAEYM
V
R
A
SGY
LQT
L
D
D
F
NH
I
V
L
KASE
N
G
VP
V
Y
L
R
DVA
K
V
Q
I
G
P
E
MRRGI
A
EL
NG
E
G
E
V
A
G
GV
V
I
L
RS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSS
L
P
E
GV
E
IVTT
YD
RS
QL
I
DR
A
I
D
N
LSGK
L
L
E
EF
I
V
V
A
V
V
C
A
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
I
V
M
H
F
Q
G
L
N
A
N
I
MSL
G
G
I
A
I
A
V
G
A
M
VD
A
AIV
MI
EN
AH
K
R
L
E
E
WQHQHPDATL
D
NKT
R
WQ
V
IT
D
ASV
EVG
P
AL
FISLLI
I
T
LS
FIP
I
F
T
LE
G
QE
G
R
LFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------L
N
RF
L
IRV---
----
Y
HPLLL
KVL
HWPKTT
L
L
V
A
A
L
SVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TD
K
--
LIMSVPE
V
A
R
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMD
K
II
E
EL
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LST
G
IK
S
PIGIK
V
SGTVLADI
D
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
LE
GGRYIN
V
E
IN
RE
KA
A
R
Y
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DS
P
QA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YI
D
A
RDRD
M
V
S
V
V
HDLQKAIAEK
V
Q
LK
P
G
TSVA
F
S
G
--
-Q
FE
LL
E
RANHKLK
L
M
VP
M
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAI
E
AE
PSLNNPQTFSE
QKLD
EA
LYH
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
GAGS
E
VMSR
I
A
A
PM
I
GGM
IT
A
P
LL
S
L
F
II
P
AA
Y
K
L
M
WLHRHRVRK
fig|216592.3.peg.634
Escherichia coli 042
MIEWIIRR
S
VA
NRF
L
VLMG
A
L
F
L
S
I
W
G
TWT
I
IN
T
PV
D
AL
P
D
L
SD
V
Q
V
I
I
K
T
S
YPG
Q
A
P
Q
I
V
E
N
Q
VT
Y
PLT
TT
M
LS
V
P
G
AK
T
VRG
F
S
QF-
G
DSY
VYV
I
FE
D
GT
D
P
Y
W
A
RS
R
V
L
EY
L
N
Q
V
QGK
LP
A-----
GV
SAELGPDAT
GVG
W
I
YEY
A
LV
D
RSGKHDLA
D
L
R
S
L
Q
DWF
L
KYE
L
K
TIP
D
V
A
E
V
ASV
G
GVVKEY
QV
V
I
DP
QR
L
A
QYG
I
SLAE
V
KS
A
L
DAS
N
QEAGG
SSI
--
-
-
--ELAEAEYM
V
R
A
SGY
LQT
L
D
D
F
NH
I
V
L
KASE
N
G
VP
V
Y
L
R
DVA
K
V
Q
I
G
P
E
MRRGI
A
EL
NG
E
G
E
V
A
G
GV
V
I
L
RS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSS
L
P
E
GV
E
IVTT
YD
RS
QL
I
DR
A
I
D
N
LSGK
L
L
E
EF
I
V
V
A
V
V
C
A
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
I
V
M
H
F
Q
G
L
N
A
N
I
MSL
G
G
I
A
I
A
V
G
A
M
VD
A
AIV
MI
EN
AH
K
R
L
E
E
WQHQHPDATL
D
NKT
R
WQ
V
IT
D
ASV
EVG
P
AL
FISLLI
I
T
LS
FIP
I
F
T
LE
G
QE
G
R
LFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------L
N
RF
L
IRV---
----
Y
HPLLL
KVL
HWPKTT
L
L
V
A
A
L
SVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TD
K
--
LIMSVPE
V
A
R
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMD
K
II
E
EL
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LST
G
IK
S
PIGIK
V
SGTVLADI
D
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
LE
GGRYIN
V
E
IN
RE
KA
A
R
Y
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DS
P
QA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YI
D
A
RDRD
M
V
S
V
V
HDLQKAIAEK
V
Q
LK
P
G
TSVA
F
S
G
--
-Q
FE
LL
E
RANHKLK
L
M
VP
M
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAI
E
AE
PSLNNPQTFSE
QKLD
EA
LYH
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
GAGS
E
VMSR
I
A
A
PM
I
GGM
IT
A
P
LL
S
L
F
II
P
AA
Y
K
L
M
WLHRHRVRK
fig|656414.3.peg.748
Escherichia coli H736
MIEWIIRR
S
VA
NRF
L
VLMG
A
L
F
L
S
I
W
G
TWT
I
IN
T
PV
D
AL
P
D
L
SD
V
Q
V
I
I
K
T
S
YPG
Q
A
P
Q
I
V
E
N
Q
VT
Y
PLT
TT
M
LS
V
P
G
AK
T
VRG
F
S
QF-
G
DSY
VYV
I
FE
D
GT
D
P
Y
W
A
RS
R
V
L
EY
L
N
Q
V
QGK
LP
A-----
GV
SAELGPDAT
GVG
W
I
YEY
A
LV
D
RSGKHDLA
D
L
R
S
L
Q
DWF
L
KYE
L
K
TIP
D
V
A
E
V
ASV
G
GVVKEY
QV
V
I
DP
QR
L
A
QYG
I
SLAE
V
KS
A
L
DAS
N
QEAGG
SSI
--
-
-
--ELAEAEYM
V
R
A
SGY
LQT
L
D
D
F
NH
I
V
L
KASE
N
G
VP
V
Y
L
R
DVA
K
V
Q
I
G
P
E
MRRGI
A
EL
NG
E
G
E
V
A
G
GV
V
I
L
RS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSS
L
P
E
GV
E
IVTT
YD
RS
QL
I
DR
A
I
D
N
LSGK
L
L
E
EF
I
V
V
A
V
V
C
A
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
I
V
M
H
F
Q
G
L
N
A
N
I
MSL
G
G
I
A
I
A
V
G
A
M
VD
A
AIV
MI
EN
AH
K
R
L
E
E
WQHQHPDATL
D
NKT
R
WQ
V
IT
D
ASV
EVG
P
AL
FISLLI
I
T
LS
FIP
I
F
T
LE
G
QE
G
R
LFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------L
N
RF
L
IRV---
----
Y
HPLLL
KVL
HWPKTT
L
L
V
A
A
L
SVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TD
K
--
LIMSVPE
V
A
R
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMD
K
II
E
EL
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LST
G
IK
S
PIGIK
V
SGTVLADI
D
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
LE
GGRYIN
V
E
IN
RE
KA
A
R
Y
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DS
P
QA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YI
D
A
RDRD
M
V
S
V
V
HDLQKAIAEK
V
Q
LK
P
G
TSVA
F
S
G
--
-Q
FE
LL
E
RANHKLK
L
M
VP
M
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAI
E
AE
PSLNNPQTFSE
QKLD
EA
LYH
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
GAGS
E
VMSR
I
A
A
PM
I
GGM
IT
A
P
LL
S
L
F
II
P
AA
Y
K
L
M
WLHRHRVRK
fig|550677.3.peg.993
Escherichia coli B354
MIEWIIRR
S
VA
NRF
L
VLMG
A
L
F
L
S
I
W
G
TWT
I
IN
T
PV
D
AL
P
D
L
SD
V
Q
V
I
I
K
T
S
YPG
Q
A
P
Q
I
V
E
N
Q
VT
Y
PLT
TT
M
LS
V
P
G
AK
T
VRG
F
S
QF-
G
DSY
VYV
I
FE
D
GT
D
P
Y
W
A
RS
R
V
L
EY
L
N
Q
V
QGK
LP
A-----
GV
SAELGPDAT
GVG
W
I
YEY
A
LV
D
RSGKHDLA
D
L
R
S
L
Q
DWF
L
KYE
L
K
TIP
D
V
A
E
V
ASV
G
GVVKEY
QV
V
I
DP
QR
L
A
QYG
I
SLAE
V
KS
A
L
DAS
N
QEAGG
SSI
--
-
-
--ELAEAEYM
V
R
A
SGY
LQT
L
D
D
F
NH
I
V
L
KASE
N
G
VP
V
Y
L
R
DVA
K
V
Q
I
G
P
E
MRRGI
A
EL
NG
E
G
E
V
A
G
GV
V
I
L
RS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSS
L
P
E
GV
E
IVTT
YD
RS
QL
I
DR
A
I
D
N
LSGK
L
L
E
EF
I
V
V
A
V
V
C
A
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
I
V
M
H
F
Q
G
L
N
A
N
I
MSL
G
G
I
A
I
A
V
G
A
M
VD
A
AIV
MI
EN
AH
K
R
L
E
E
WQHQHPDATL
D
NKT
R
WQ
V
IT
D
ASV
EVG
P
AL
FISLLI
I
T
LS
FIP
I
F
T
LE
G
QE
G
R
LFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------L
N
RF
L
IRV---
----
Y
HPLLL
KVL
HWPKTT
L
L
V
A
A
L
SVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TD
K
--
LIMSVPE
V
A
R
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QD
QW
R
PG--MTMD
K
II
E
EL
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LST
G
IK
S
PIGIK
V
SGTVLADI
D
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
LE
GGRYIN
V
E
IN
RE
KA
A
R
Y
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DS
P
QA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YI
D
A
RDRD
M
V
S
V
V
HDLQKAIAEK
V
Q
LK
P
G
TSVA
F
S
G
--
-Q
FE
LL
E
RANHKLK
L
M
VP
M
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAI
E
AE
PSLNNPQTFSE
QKLD
EA
LYH
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
GAGS
E
VMSR
I
A
A
PM
I
GGM
IT
A
P
LL
S
L
F
II
P
AA
Y
K
L
M
WLHRHRVRK
fig|340184.3.peg.4467
Escherichia coli B7A
MIEWIIRR
S
VA
NRF
L
VLMG
A
L
F
L
S
I
W
G
TWT
I
IN
T
PV
D
AL
P
D
L
SD
V
Q
V
I
I
K
T
S
YPG
Q
A
P
Q
I
V
E
N
Q
VT
Y
PLT
TT
M
LS
V
P
G
AK
T
VRG
F
S
QF-
G
DSY
VYV
I
FE
D
GT
D
P
Y
W
A
RS
R
V
L
EY
L
N
Q
V
QGK
LP
A-----
GV
SAELGPDAT
GVG
W
I
YEY
A
LV
D
RSGKHDLA
D
L
R
S
L
Q
DWF
L
KYE
L
K
TIP
D
V
A
E
V
ASV
G
GVVKEY
QV
V
I
DP
QR
L
A
QYG
I
SLAE
V
KS
A
L
DAS
N
QEAGG
SSI
--
-
-
--ELAEAEYM
V
R
A
SGY
LQT
L
D
D
F
NH
I
V
L
KASE
N
G
VP
V
Y
L
R
DVA
K
V
Q
I
G
P
E
MRRGI
A
EL
NG
E
G
E
V
A
G
GV
V
I
L
RS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSS
L
P
E
GV
E
IVTT
YD
RS
QL
I
DR
A
I
D
N
LSGK
L
L
E
EF
I
V
V
A
V
V
C
A
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
I
V
M
H
F
Q
G
L
N
A
N
I
MSL
G
G
I
A
I
A
V
G
A
M
VD
A
AIV
MI
EN
AH
K
R
L
E
E
WQHQHPDATL
D
NKT
R
WQ
V
IT
D
ASV
EVG
P
AL
FISLLI
I
T
LS
FIP
I
F
T
LE
G
QE
G
R
LFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------L
N
RF
L
IRV---
----
Y
HPLLL
KVL
HWPKTT
L
L
V
A
A
L
SVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TD
K
--
LIMSVPE
V
A
R
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QD
QW
R
PG--MTMD
K
II
E
EL
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LST
G
IK
S
PIGIK
V
SGTVLADI
D
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
LE
GGRYIN
V
E
IN
RE
KA
A
R
Y
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DS
P
QA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YI
D
A
RDRD
M
V
S
V
V
HDLQKAIAEK
V
Q
LK
P
G
TSVA
F
S
G
--
-Q
FE
LL
E
RANHKLK
L
M
VP
M
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAI
E
AE
PSLNNPQTFSE
QKLD
EA
LYH
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
GAGS
E
VMSR
I
A
A
PM
I
GGM
IT
A
P
LL
S
L
F
II
P
AA
Y
K
L
M
WLHRHRVRK
fig|340184.6.peg.4678
Escherichia coli B7A
MIEWIIRR
S
VA
NRF
L
VLMG
A
L
F
L
S
I
W
G
TWT
I
IN
T
PV
D
AL
P
D
L
SD
V
Q
V
I
I
K
T
S
YPG
Q
A
P
Q
I
V
E
N
Q
VT
Y
PLT
TT
M
LS
V
P
G
AK
T
VRG
F
S
QF-
G
DSY
VYV
I
FE
D
GT
D
P
Y
W
A
RS
R
V
L
EY
L
N
Q
V
QGK
LP
A-----
GV
SAELGPDAT
GVG
W
I
YEY
A
LV
D
RSGKHDLA
D
L
R
S
L
Q
DWF
L
KYE
L
K
TIP
D
V
A
E
V
ASV
G
GVVKEY
QV
V
I
DP
QR
L
A
QYG
I
SLAE
V
KS
A
L
DAS
N
QEAGG
SSI
--
-
-
--ELAEAEYM
V
R
A
SGY
LQT
L
D
D
F
NH
I
V
L
KASE
N
G
VP
V
Y
L
R
DVA
K
V
Q
I
G
P
E
MRRGI
A
EL
NG
E
G
E
V
A
G
GV
V
I
L
RS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSS
L
P
E
GV
E
IVTT
YD
RS
QL
I
DR
A
I
D
N
LSGK
L
L
E
EF
I
V
V
A
V
V
C
A
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
I
V
M
H
F
Q
G
L
N
A
N
I
MSL
G
G
I
A
I
A
V
G
A
M
VD
A
AIV
MI
EN
AH
K
R
L
E
E
WQHQHPDATL
D
NKT
R
WQ
V
IT
D
ASV
EVG
P
AL
FISLLI
I
T
LS
FIP
I
F
T
LE
G
QE
G
R
LFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------L
N
RF
L
IRV---
----
Y
HPLLL
KVL
HWPKTT
L
L
V
A
A
L
SVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TD
K
--
LIMSVPE
V
A
R
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QD
QW
R
PG--MTMD
K
II
E
EL
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LST
G
IK
S
PIGIK
V
SGTVLADI
D
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
LE
GGRYIN
V
E
IN
RE
KA
A
R
Y
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DS
P
QA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YI
D
A
RDRD
M
V
S
V
V
HDLQKAIAEK
V
Q
LK
P
G
TSVA
F
S
G
--
-Q
FE
LL
E
RANHKLK
L
M
VP
M
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAI
E
AE
PSLNNPQTFSE
QKLD
EA
LYH
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
GAGS
E
VMSR
I
A
A
PM
I
GGM
IT
A
P
LL
S
L
F
II
P
AA
Y
K
L
M
WLHRHRVRK
fig|331111.12.peg.899
Escherichia coli E24377A
MIEWIIRR
S
VA
NRF
L
VLMG
A
L
F
L
S
I
W
G
TWT
I
IN
T
PV
D
AL
P
D
L
SD
V
Q
V
I
I
K
T
S
YPG
Q
A
P
Q
I
V
E
N
Q
VT
Y
PLT
TT
M
LS
V
P
G
AK
T
VRG
F
S
QF-
G
DSY
VYV
I
FE
D
GT
D
P
Y
W
A
RS
R
V
L
EY
L
N
Q
V
QGK
LP
A-----
GV
SAELGPDAT
GVG
W
I
YEY
A
LV
D
RSGKHDLA
D
L
R
S
L
Q
DWF
L
KYE
L
K
TIP
D
V
A
E
V
ASV
G
GVVKEY
QV
V
I
DP
QR
L
A
QYG
I
SLAE
V
KS
A
L
DAS
N
QEAGG
SSI
--
-
-
--ELAEAEYM
V
R
A
SGY
LQT
L
D
D
F
NH
I
V
L
KASE
N
G
VP
V
Y
L
R
DVA
K
V
Q
I
G
P
E
MRRGI
A
EL
NG
E
G
E
V
A
G
GV
V
I
L
RS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSS
L
P
E
GV
E
IVTT
YD
RS
QL
I
DR
A
I
D
N
LSGK
L
L
E
EF
I
V
V
A
V
V
C
A
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
I
V
M
H
F
Q
G
L
N
A
N
I
MSL
G
G
I
A
I
A
V
G
A
M
VD
A
AIV
MI
EN
AH
K
R
L
E
E
WQHQHPDATL
D
NKT
R
WQ
V
IT
D
ASV
EVG
P
AL
FISLLI
I
T
LS
FIP
I
F
T
LE
G
QE
G
R
LFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------L
N
RF
L
IRV---
----
Y
HPLLL
KVL
HWPKTT
L
L
V
A
A
L
SVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TD
K
--
LIMSVPE
V
A
R
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QD
QW
R
PG--MTMD
K
II
E
EL
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LST
G
IK
S
PIGIK
V
SGTVLADI
D
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
LE
GGRYIN
V
E
IN
RE
KA
A
R
Y
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DS
P
QA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YI
D
A
RDRD
M
V
S
V
V
HDLQKAIAEK
V
Q
LK
P
G
TSVA
F
S
G
--
-Q
FE
LL
E
RANHKLK
L
M
VP
M
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAI
E
AE
PSLNNPQTFSE
QKLD
EA
LYH
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
GAGS
E
VMSR
I
A
A
PM
I
GGM
IT
A
P
LL
S
L
F
II
P
AA
Y
K
L
M
WLHRHRVRK
fig|331111.3.peg.3124
Escherichia coli E24377A
MIEWIIRR
S
VA
NRF
L
VLMG
A
L
F
L
S
I
W
G
TWT
I
IN
T
PV
D
AL
P
D
L
SD
V
Q
V
I
I
K
T
S
YPG
Q
A
P
Q
I
V
E
N
Q
VT
Y
PLT
TT
M
LS
V
P
G
AK
T
VRG
F
S
QF-
G
DSY
VYV
I
FE
D
GT
D
P
Y
W
A
RS
R
V
L
EY
L
N
Q
V
QGK
LP
A-----
GV
SAELGPDAT
GVG
W
I
YEY
A
LV
D
RSGKHDLA
D
L
R
S
L
Q
DWF
L
KYE
L
K
TIP
D
V
A
E
V
ASV
G
GVVKEY
QV
V
I
DP
QR
L
A
QYG
I
SLAE
V
KS
A
L
DAS
N
QEAGG
SSI
--
-
-
--ELAEAEYM
V
R
A
SGY
LQT
L
D
D
F
NH
I
V
L
KASE
N
G
VP
V
Y
L
R
DVA
K
V
Q
I
G
P
E
MRRGI
A
EL
NG
E
G
E
V
A
G
GV
V
I
L
RS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSS
L
P
E
GV
E
IVTT
YD
RS
QL
I
DR
A
I
D
N
LSGK
L
L
E
EF
I
V
V
A
V
V
C
A
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
I
V
M
H
F
Q
G
L
N
A
N
I
MSL
G
G
I
A
I
A
V
G
A
M
VD
A
AIV
MI
EN
AH
K
R
L
E
E
WQHQHPDATL
D
NKT
R
WQ
V
IT
D
ASV
EVG
P
AL
FISLLI
I
T
LS
FIP
I
F
T
LE
G
QE
G
R
LFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------L
N
RF
L
IRV---
----
Y
HPLLL
KVL
HWPKTT
L
L
V
A
A
L
SVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TD
K
--
LIMSVPE
V
A
R
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QD
QW
R
PG--MTMD
K
II
E
EL
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LST
G
IK
S
PIGIK
V
SGTVLADI
D
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
LE
GGRYIN
V
E
IN
RE
KA
A
R
Y
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DS
P
QA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YI
D
A
RDRD
M
V
S
V
V
HDLQKAIAEK
V
Q
LK
P
G
TSVA
F
S
G
--
-Q
FE
LL
E
RANHKLK
L
M
VP
M
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAI
E
AE
PSLNNPQTFSE
QKLD
EA
LYH
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
GAGS
E
VMSR
I
A
A
PM
I
GGM
IT
A
P
LL
S
L
F
II
P
AA
Y
K
L
M
WLHRHRVRK
fig|562.375.peg.1588
Escherichia coli EC4100B
MIEWIIRR
S
VA
NRF
L
VLMG
A
L
F
L
S
I
W
G
TWT
I
IN
T
PV
D
AL
P
D
L
SD
V
Q
V
I
I
K
T
S
YPG
Q
A
P
Q
I
V
E
N
Q
VT
Y
PLT
TT
M
LS
V
P
G
AK
T
VRG
F
S
QF-
G
DSY
VYV
I
FE
D
GT
D
P
Y
W
A
RS
R
V
L
EY
L
N
Q
V
QGK
LP
A-----
GV
SAELGPDAT
GVG
W
I
YEY
A
LV
D
RSGKHDLA
D
L
R
S
L
Q
DWF
L
KYE
L
K
TIP
D
V
A
E
V
ASV
G
GVVKEY
QV
V
I
DP
QR
L
A
QYG
I
SLAE
V
KS
A
L
DAS
N
QEAGG
SSI
--
-
-
--ELAEAEYM
V
R
A
SGY
LQT
L
D
D
F
NH
I
V
L
KASE
N
G
VP
V
Y
L
R
DVA
K
V
Q
I
G
P
E
MRRGI
A
EL
NG
E
G
E
V
A
G
GV
V
I
L
RS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSS
L
P
E
GV
E
IVTT
YD
RS
QL
I
DR
A
I
D
N
LSGK
L
L
E
EF
I
V
V
A
V
V
C
A
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
I
V
M
H
F
Q
G
L
N
A
N
I
MSL
G
G
I
A
I
A
V
G
A
M
VD
A
AIV
MI
EN
AH
K
R
L
E
E
WQHQHPDATL
D
NKT
R
WQ
V
IT
D
ASV
EVG
P
AL
FISLLI
I
T
LS
FIP
I
F
T
LE
G
QE
G
R
LFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------L
N
RF
L
IRV---
----
Y
HPLLL
KVL
HWPKTT
L
L
V
A
A
L
SVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TD
K
--
LIMSVPE
V
A
R
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QD
QW
R
PG--MTMD
K
II
E
EL
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LST
G
IK
S
PIGIK
V
SGTVLADI
D
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
LE
GGRYIN
V
E
IN
RE
KA
A
R
Y
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DS
P
QA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YI
D
A
RDRD
M
V
S
V
V
HDLQKAIAEK
V
Q
LK
P
G
TSVA
F
S
G
--
-Q
FE
LL
E
RANHKLK
L
M
VP
M
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAI
E
AE
PSLNNPQTFSE
QKLD
EA
LYH
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
GAGS
E
VMSR
I
A
A
PM
I
GGM
IT
A
P
LL
S
L
F
II
P
AA
Y
K
L
M
WLHRHRVRK
fig|595495.4.peg.2045
Escherichia coli KO11
MIEWIIRR
S
VA
NRF
L
VLMG
A
L
F
L
S
I
W
G
TWT
I
IN
T
PV
D
AL
P
D
L
SD
V
Q
V
I
I
K
T
S
YPG
Q
A
P
Q
I
V
E
N
Q
VT
Y
PLT
TT
M
LS
V
P
G
AK
T
VRG
F
S
QF-
G
DSY
VYV
I
FE
D
GT
D
P
Y
W
A
RS
R
V
L
EY
L
N
Q
V
QGK
LP
A-----
GV
SAELGPDAT
GVG
W
I
YEY
A
LV
D
RSGKHDLA
D
L
R
S
L
Q
DWF
L
KYE
L
K
TIP
D
V
A
E
V
ASV
G
GVVKEY
QV
V
I
DP
QR
L
A
QYG
I
SLAE
V
KS
A
L
DAS
N
QEAGG
SSI
--
-
-
--ELAEAEYM
V
R
A
SGY
LQT
L
D
D
F
NH
I
V
L
KASE
N
G
VP
V
Y
L
R
DVA
K
V
Q
I
G
P
E
MRRGI
A
EL
NG
E
G
E
V
A
G
GV
V
I
L
RS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSS
L
P
E
GV
E
IVTT
YD
RS
QL
I
DR
A
I
D
N
LSGK
L
L
E
EF
I
V
V
A
V
V
C
A
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
I
V
M
H
F
Q
G
L
N
A
N
I
MSL
G
G
I
A
I
A
V
G
A
M
VD
A
AIV
MI
EN
AH
K
R
L
E
E
WQHQHPDATL
D
NKT
R
WQ
V
IT
D
ASV
EVG
P
AL
FISLLI
I
T
LS
FIP
I
F
T
LE
G
QE
G
R
LFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------L
N
RF
L
IRV---
----
Y
HPLLL
KVL
HWPKTT
L
L
V
A
A
L
SVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TD
K
--
LIMSVPE
V
A
R
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QD
QW
R
PG--MTMD
K
II
E
EL
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LST
G
IK
S
PIGIK
V
SGTVLADI
D
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
LE
GGRYIN
V
E
IN
RE
KA
A
R
Y
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DS
P
QA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YI
D
A
RDRD
M
V
S
V
V
HDLQKAIAEK
V
Q
LK
P
G
TSVA
F
S
G
--
-Q
FE
LL
E
RANHKLK
L
M
VP
M
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAI
E
AE
PSLNNPQTFSE
QKLD
EA
LYH
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
GAGS
E
VMSR
I
A
A
PM
I
GGM
IT
A
P
LL
S
L
F
II
P
AA
Y
K
L
M
WLHRHRVRK
fig|679204.3.peg.5117
Escherichia coli MS 145-7
MIEWIIRR
S
VA
NRF
L
VLMG
A
L
F
L
S
I
W
G
TWT
I
IN
T
PV
D
AL
P
D
L
SD
V
Q
V
I
I
K
T
S
YPG
Q
A
P
Q
I
V
E
N
Q
VT
Y
PLT
TT
M
LS
V
P
G
AK
T
VRG
F
S
QF-
G
DSY
VYV
I
FE
D
GT
D
P
Y
W
A
RS
R
V
L
EY
L
N
Q
V
QGK
LP
A-----
GV
SAELGPDAT
GVG
W
I
YEY
A
LV
D
RSGKHDLA
D
L
R
S
L
Q
DWF
L
KYE
L
K
TIP
D
V
A
E
V
ASV
G
GVVKEY
QV
V
I
DP
QR
L
A
QYG
I
SLAE
V
KS
A
L
DAS
N
QEAGG
SSI
--
-
-
--ELAEAEYM
V
R
A
SGY
LQT
L
D
D
F
NH
I
V
L
KASE
N
G
VP
V
Y
L
R
DVA
K
V
Q
I
G
P
E
MRRGI
A
EL
NG
E
G
E
V
A
G
GV
V
I
L
RS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSS
L
P
E
GV
E
IVTT
YD
RS
QL
I
DR
A
I
D
N
LSGK
L
L
E
EF
I
V
V
A
V
V
C
A
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
I
V
M
H
F
Q
G
L
N
A
N
I
MSL
G
G
I
A
I
A
V
G
A
M
VD
A
AIV
MI
EN
AH
K
R
L
E
E
WQHQHPDATL
D
NKT
R
WQ
V
IT
D
ASV
EVG
P
AL
FISLLI
I
T
LS
FIP
I
F
T
LE
G
QE
G
R
LFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------L
N
RF
L
IRV---
----
Y
HPLLL
KVL
HWPKTT
L
L
V
A
A
L
SVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TD
K
--
LIMSVPE
V
A
R
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QD
QW
R
PG--MTMD
K
II
E
EL
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LST
G
IK
S
PIGIK
V
SGTVLADI
D
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
LE
GGRYIN
V
E
IN
RE
KA
A
R
Y
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DS
P
QA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YI
D
A
RDRD
M
V
S
V
V
HDLQKAIAEK
V
Q
LK
P
G
TSVA
F
S
G
--
-Q
FE
LL
E
RANHKLK
L
M
VP
M
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAI
E
AE
PSLNNPQTFSE
QKLD
EA
LYH
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
GAGS
E
VMSR
I
A
A
PM
I
GGM
IT
A
P
LL
S
L
F
II
P
AA
Y
K
L
M
WLHRHRVRK
fig|749532.3.peg.3646
Escherichia coli MS 78-1
MIEWIIRR
S
VA
NRF
L
VLMG
A
L
F
L
S
I
W
G
TWT
I
IN
T
PV
D
AL
P
D
L
SD
V
Q
V
I
I
K
T
S
YPG
Q
A
P
Q
I
V
E
N
Q
VT
Y
PLT
TT
M
LS
V
P
G
AK
T
VRG
F
S
QF-
G
DSY
VYV
I
FE
D
GT
D
P
Y
W
A
RS
R
V
L
EY
L
N
Q
V
QGK
LP
A-----
GV
SAELGPDAT
GVG
W
I
YEY
A
LV
D
RSGKHDLA
D
L
R
S
L
Q
DWF
L
KYE
L
K
TIP
D
V
A
E
V
ASV
G
GVVKEY
QV
V
I
DP
QR
L
A
QYG
I
SLAE
V
KS
A
L
DAS
N
QEAGG
SSI
--
-
-
--ELAEAEYM
V
R
A
SGY
LQT
L
D
D
F
NH
I
V
L
KASE
N
G
VP
V
Y
L
R
DVA
K
V
Q
I
G
P
E
MRRGI
A
EL
NG
E
G
E
V
A
G
GV
V
I
L
RS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSS
L
P
E
GV
E
IVTT
YD
RS
QL
I
DR
A
I
D
N
LSGK
L
L
E
EF
I
V
V
A
V
V
C
A
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
I
V
M
H
F
Q
G
L
N
A
N
I
MSL
G
G
I
A
I
A
V
G
A
M
VD
A
AIV
MI
EN
AH
K
R
L
E
E
WQHQHPDATL
D
NKT
R
WQ
V
IT
D
ASV
EVG
P
AL
FISLLI
I
T
LS
FIP
I
F
T
LE
G
QE
G
R
LFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------L
N
RF
L
IRV---
----
Y
HPLLL
KVL
HWPKTT
L
L
V
A
A
L
SVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TD
K
--
LIMSVPE
V
A
R
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QD
QW
R
PG--MTMD
K
II
E
EL
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LST
G
IK
S
PIGIK
V
SGTVLADI
D
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
LE
GGRYIN
V
E
IN
RE
KA
A
R
Y
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DS
P
QA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YI
D
A
RDRD
M
V
S
V
V
HDLQKAIAEK
V
Q
LK
P
G
TSVA
F
S
G
--
-Q
FE
LL
E
RANHKLK
L
M
VP
M
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAI
E
AE
PSLNNPQTFSE
QKLD
EA
LYH
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
GAGS
E
VMSR
I
A
A
PM
I
GGM
IT
A
P
LL
S
L
F
II
P
AA
Y
K
L
M
WLHRHRVRK
fig|409438.11.peg.764
Escherichia coli SE11
MIEWIIRR
S
VA
NRF
L
VLMG
A
L
F
L
S
I
W
G
TWT
I
IN
T
PV
D
AL
P
D
L
SD
V
Q
V
I
I
K
T
S
YPG
Q
A
P
Q
I
V
E
N
Q
VT
Y
PLT
TT
M
LS
V
P
G
AK
T
VRG
F
S
QF-
G
DSY
VYV
I
FE
D
GT
D
P
Y
W
A
RS
R
V
L
EY
L
N
Q
V
QGK
LP
A-----
GV
SAELGPDAT
GVG
W
I
YEY
A
LV
D
RSGKHDLA
D
L
R
S
L
Q
DWF
L
KYE
L
K
TIP
D
V
A
E
V
ASV
G
GVVKEY
QV
V
I
DP
QR
L
A
QYG
I
SLAE
V
KS
A
L
DAS
N
QEAGG
SSI
--
-
-
--ELAEAEYM
V
R
A
SGY
LQT
L
D
D
F
NH
I
V
L
KASE
N
G
VP
V
Y
L
R
DVA
K
V
Q
I
G
P
E
MRRGI
A
EL
NG
E
G
E
V
A
G
GV
V
I
L
RS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSS
L
P
E
GV
E
IVTT
YD
RS
QL
I
DR
A
I
D
N
LSGK
L
L
E
EF
I
V
V
A
V
V
C
A
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
I
V
M
H
F
Q
G
L
N
A
N
I
MSL
G
G
I
A
I
A
V
G
A
M
VD
A
AIV
MI
EN
AH
K
R
L
E
E
WQHQHPDATL
D
NKT
R
WQ
V
IT
D
ASV
EVG
P
AL
FISLLI
I
T
LS
FIP
I
F
T
LE
G
QE
G
R
LFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------L
N
RF
L
IRV---
----
Y
HPLLL
KVL
HWPKTT
L
L
V
A
A
L
SVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TD
K
--
LIMSVPE
V
A
R
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QD
QW
R
PG--MTMD
K
II
E
EL
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LST
G
IK
S
PIGIK
V
SGTVLADI
D
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
LE
GGRYIN
V
E
IN
RE
KA
A
R
Y
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DS
P
QA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YI
D
A
RDRD
M
V
S
V
V
HDLQKAIAEK
V
Q
LK
P
G
TSVA
F
S
G
--
-Q
FE
LL
E
RANHKLK
L
M
VP
M
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAI
E
AE
PSLNNPQTFSE
QKLD
EA
LYH
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
GAGS
E
VMSR
I
A
A
PM
I
GGM
IT
A
P
LL
S
L
F
II
P
AA
Y
K
L
M
WLHRHRVRK
fig|566546.3.peg.4930
Escherichia coli W
MIEWIIRR
S
VA
NRF
L
VLMG
A
L
F
L
S
I
W
G
TWT
I
IN
T
PV
D
AL
P
D
L
SD
V
Q
V
I
I
K
T
S
YPG
Q
A
P
Q
I
V
E
N
Q
VT
Y
PLT
TT
M
LS
V
P
G
AK
T
VRG
F
S
QF-
G
DSY
VYV
I
FE
D
GT
D
P
Y
W
A
RS
R
V
L
EY
L
N
Q
V
QGK
LP
A-----
GV
SAELGPDAT
GVG
W
I
YEY
A
LV
D
RSGKHDLA
D
L
R
S
L
Q
DWF
L
KYE
L
K
TIP
D
V
A
E
V
ASV
G
GVVKEY
QV
V
I
DP
QR
L
A
QYG
I
SLAE
V
KS
A
L
DAS
N
QEAGG
SSI
--
-
-
--ELAEAEYM
V
R
A
SGY
LQT
L
D
D
F
NH
I
V
L
KASE
N
G
VP
V
Y
L
R
DVA
K
V
Q
I
G
P
E
MRRGI
A
EL
NG
E
G
E
V
A
G
GV
V
I
L
RS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSS
L
P
E
GV
E
IVTT
YD
RS
QL
I
DR
A
I
D
N
LSGK
L
L
E
EF
I
V
V
A
V
V
C
A
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
I
V
M
H
F
Q
G
L
N
A
N
I
MSL
G
G
I
A
I
A
V
G
A
M
VD
A
AIV
MI
EN
AH
K
R
L
E
E
WQHQHPDATL
D
NKT
R
WQ
V
IT
D
ASV
EVG
P
AL
FISLLI
I
T
LS
FIP
I
F
T
LE
G
QE
G
R
LFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------L
N
RF
L
IRV---
----
Y
HPLLL
KVL
HWPKTT
L
L
V
A
A
L
SVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TD
K
--
LIMSVPE
V
A
R
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QD
QW
R
PG--MTMD
K
II
E
EL
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LST
G
IK
S
PIGIK
V
SGTVLADI
D
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
LE
GGRYIN
V
E
IN
RE
KA
A
R
Y
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DS
P
QA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YI
D
A
RDRD
M
V
S
V
V
HDLQKAIAEK
V
Q
LK
P
G
TSVA
F
S
G
--
-Q
FE
LL
E
RANHKLK
L
M
VP
M
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAI
E
AE
PSLNNPQTFSE
QKLD
EA
LYH
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
GAGS
E
VMSR
I
A
A
PM
I
GGM
IT
A
P
LL
S
L
F
II
P
AA
Y
K
L
M
WLHRHRVRK
fig|566546.4.peg.631
Escherichia coli W
MIEWIIRR
S
VA
NRF
L
VLMG
A
L
F
L
S
I
W
G
TWT
I
IN
T
PV
D
AL
P
D
L
SD
V
Q
V
I
I
K
T
S
YPG
Q
A
P
Q
I
V
E
N
Q
VT
Y
PLT
TT
M
LS
V
P
G
AK
T
VRG
F
S
QF-
G
DSY
VYV
I
FE
D
GT
D
P
Y
W
A
RS
R
V
L
EY
L
N
Q
V
QGK
LP
A-----
GV
SAELGPDAT
GVG
W
I
YEY
A
LV
D
RSGKHDLA
D
L
R
S
L
Q
DWF
L
KYE
L
K
TIP
D
V
A
E
V
ASV
G
GVVKEY
QV
V
I
DP
QR
L
A
QYG
I
SLAE
V
KS
A
L
DAS
N
QEAGG
SSI
--
-
-
--ELAEAEYM
V
R
A
SGY
LQT
L
D
D
F
NH
I
V
L
KASE
N
G
VP
V
Y
L
R
DVA
K
V
Q
I
G
P
E
MRRGI
A
EL
NG
E
G
E
V
A
G
GV
V
I
L
RS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSS
L
P
E
GV
E
IVTT
YD
RS
QL
I
DR
A
I
D
N
LSGK
L
L
E
EF
I
V
V
A
V
V
C
A
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
I
V
M
H
F
Q
G
L
N
A
N
I
MSL
G
G
I
A
I
A
V
G
A
M
VD
A
AIV
MI
EN
AH
K
R
L
E
E
WQHQHPDATL
D
NKT
R
WQ
V
IT
D
ASV
EVG
P
AL
FISLLI
I
T
LS
FIP
I
F
T
LE
G
QE
G
R
LFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------L
N
RF
L
IRV---
----
Y
HPLLL
KVL
HWPKTT
L
L
V
A
A
L
SVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TD
K
--
LIMSVPE
V
A
R
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QD
QW
R
PG--MTMD
K
II
E
EL
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LST
G
IK
S
PIGIK
V
SGTVLADI
D
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
LE
GGRYIN
V
E
IN
RE
KA
A
R
Y
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DS
P
QA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YI
D
A
RDRD
M
V
S
V
V
HDLQKAIAEK
V
Q
LK
P
G
TSVA
F
S
G
--
-Q
FE
LL
E
RANHKLK
L
M
VP
M
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAI
E
AE
PSLNNPQTFSE
QKLD
EA
LYH
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
GAGS
E
VMSR
I
A
A
PM
I
GGM
IT
A
P
LL
S
L
F
II
P
AA
Y
K
L
M
WLHRHRVRK
fig|358709.5.peg.1979
Escherichia coli 101-1
MIEWIIRR
S
VA
NRF
L
VLMG
A
L
F
L
S
I
W
G
TWT
I
IN
T
PV
D
AL
P
D
L
SD
V
Q
V
I
I
K
T
S
YPG
Q
A
P
Q
I
V
E
N
Q
VT
Y
PLT
TT
M
LS
V
P
G
AK
T
VRG
F
S
QF-
G
DSY
VYV
I
FE
D
GT
D
P
Y
W
A
RS
R
V
L
EY
L
N
Q
V
QGK
LP
A-----
GV
SAELGPDAT
GVG
W
I
YEY
A
LV
D
RSGKHDLA
D
L
R
S
L
Q
DWF
L
KYE
L
K
TIP
D
V
A
E
V
ASV
G
GVVKEY
QV
V
I
DP
QR
L
A
QYG
I
SLAE
V
KS
A
L
DAS
N
QEAGG
SSI
--
-
-
--ELAEAEYM
V
R
A
SGY
LQT
L
D
D
F
NH
I
V
L
KASE
N
G
VP
V
Y
L
R
DVA
K
V
Q
I
G
P
E
MRRGI
A
EL
NG
E
G
E
V
A
G
GV
V
I
L
RS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSS
L
P
E
GV
E
IVTT
YD
RS
QL
I
DR
A
I
D
N
LSGK
L
L
E
EF
I
V
V
A
V
V
C
A
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
I
V
M
H
F
Q
G
L
N
A
N
I
MSL
G
G
I
A
I
A
V
G
A
M
VD
A
AIV
MI
EN
AH
K
R
L
E
E
WQHQHPDATL
D
NKT
R
WQ
V
IT
D
ASV
EVG
P
AL
FISLLI
I
T
LS
FIP
I
F
T
LE
G
QE
G
R
LFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------L
N
RF
L
IRV---
----
Y
HPLLL
KVL
HWPKTT
L
L
V
A
A
L
SVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TD
K
--
LIMSVPE
V
A
R
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMD
K
II
E
EL
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LST
G
IK
S
PIGIK
V
SGTVLADI
D
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
LE
GGRYIN
V
E
IN
RE
KA
A
R
Y
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DS
P
QA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DIKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YI
D
A
RDRD
M
V
S
V
V
HDLQKAIAEK
V
Q
LK
P
G
TSVA
F
S
G
--
-Q
FE
LL
E
RANHKLK
L
M
VP
M
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAI
E
AV
PSLNNPQTFSE
QKLD
EA
LYH
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
GAGS
E
VMSR
I
A
A
PM
I
GGM
IT
A
P
LL
S
L
F
II
P
AA
Y
K
L
M
WLHRHRVRK
fig|670888.3.peg.1135
Escherichia coli 1827-70
MIEWIIRR
S
VA
NRF
L
VLMG
A
L
F
L
S
I
W
G
TWT
I
IN
T
PV
D
AL
P
D
L
SD
V
Q
V
I
I
K
T
S
YPG
Q
A
P
Q
I
V
E
N
Q
VT
Y
PLT
TT
M
LS
V
P
G
AK
T
VRG
F
S
QF-
G
DSY
VYV
I
FE
D
GT
D
P
Y
W
A
RS
R
V
L
EY
L
N
Q
V
QGK
LP
A-----
GV
SAELGPDAT
GVG
W
I
YEY
A
LV
D
RSGKHDLA
D
L
R
S
L
Q
DWF
L
KYE
L
K
TIP
D
V
A
E
V
ASV
G
GVVKEY
QV
V
I
DP
QR
L
A
QYG
I
SLAE
V
KS
A
L
DAS
N
QEAGG
SSI
--
-
-
--ELAEAEYM
V
R
A
SGY
LQT
L
D
D
F
NH
I
V
L
KASE
N
G
VP
V
Y
L
R
DVA
K
V
Q
I
G
P
E
MRRGI
A
EL
NG
E
G
E
V
A
G
GV
V
I
L
RS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSS
L
P
E
GV
E
IVTT
YD
RS
QL
I
DR
A
I
D
N
LSGK
L
L
E
EF
I
V
V
A
V
V
C
A
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
I
V
M
H
F
Q
G
L
N
A
N
I
MSL
G
G
I
A
I
A
V
G
A
M
VD
A
AIV
MI
EN
AH
K
R
L
E
E
WQHQHPDATL
D
NKT
R
WQ
V
IT
D
ASV
EVG
P
AL
FISLLI
I
T
LS
FIP
I
F
T
LE
G
QE
G
R
LFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------L
N
RF
L
IRV---
----
Y
HPLLL
KVL
HWPKTT
L
L
V
A
A
L
SVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TD
K
--
LIMSVPE
V
A
R
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMD
K
II
E
EL
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LST
G
IK
S
PIGIK
V
SGTVLADI
D
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
LE
GGRYIN
V
E
IN
RE
KA
A
R
Y
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DS
P
QA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DIKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YI
D
A
RDRD
M
V
S
V
V
HDLQKAIAEK
V
Q
LK
P
G
TSVA
F
S
G
--
-Q
FE
LL
E
RANHKLK
L
M
VP
M
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAI
E
AV
PSLNNPQTFSE
QKLD
EA
LYH
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
GAGS
E
VMSR
I
A
A
PM
I
GGM
IT
A
P
LL
S
L
F
II
P
AA
Y
K
L
M
WLHRHRVRK
fig|344610.3.peg.1558
Escherichia coli 53638
MIEWIIRR
S
VA
NRF
L
VLMG
A
L
F
L
S
I
W
G
TWT
I
IN
T
PV
D
AL
P
D
L
SD
V
Q
V
I
I
K
T
S
YPG
Q
A
P
Q
I
V
E
N
Q
VT
Y
PLT
TT
M
LS
V
P
G
AK
T
VRG
F
S
QF-
G
DSY
VYV
I
FE
D
GT
D
P
Y
W
A
RS
R
V
L
EY
L
N
Q
V
QGK
LP
A-----
GV
SAELGPDAT
GVG
W
I
YEY
A
LV
D
RSGKHDLA
D
L
R
S
L
Q
DWF
L
KYE
L
K
TIP
D
V
A
E
V
ASV
G
GVVKEY
QV
V
I
DP
QR
L
A
QYG
I
SLAE
V
KS
A
L
DAS
N
QEAGG
SSI
--
-
-
--ELAEAEYM
V
R
A
SGY
LQT
L
D
D
F
NH
I
V
L
KASE
N
G
VP
V
Y
L
R
DVA
K
V
Q
I
G
P
E
MRRGI
A
EL
NG
E
G
E
V
A
G
GV
V
I
L
RS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSS
L
P
E
GV
E
IVTT
YD
RS
QL
I
DR
A
I
D
N
LSGK
L
L
E
EF
I
V
V
A
V
V
C
A
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
I
V
M
H
F
Q
G
L
N
A
N
I
MSL
G
G
I
A
I
A
V
G
A
M
VD
A
AIV
MI
EN
AH
K
R
L
E
E
WQHQHPDATL
D
NKT
R
WQ
V
IT
D
ASV
EVG
P
AL
FISLLI
I
T
LS
FIP
I
F
T
LE
G
QE
G
R
LFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------L
N
RF
L
IRV---
----
Y
HPLLL
KVL
HWPKTT
L
L
V
A
A
L
SVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TD
K
--
LIMSVPE
V
A
R
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMD
K
II
E
EL
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LST
G
IK
S
PIGIK
V
SGTVLADI
D
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
LE
GGRYIN
V
E
IN
RE
KA
A
R
Y
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DS
P
QA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DIKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YI
D
A
RDRD
M
V
S
V
V
HDLQKAIAEK
V
Q
LK
P
G
TSVA
F
S
G
--
-Q
FE
LL
E
RANHKLK
L
M
VP
M
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAI
E
AV
PSLNNPQTFSE
QKLD
EA
LYH
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
GAGS
E
VMSR
I
A
A
PM
I
GGM
IT
A
P
LL
S
L
F
II
P
AA
Y
K
L
M
WLHRHRVRK
fig|344610.7.peg.1121
Escherichia coli 53638
MIEWIIRR
S
VA
NRF
L
VLMG
A
L
F
L
S
I
W
G
TWT
I
IN
T
PV
D
AL
P
D
L
SD
V
Q
V
I
I
K
T
S
YPG
Q
A
P
Q
I
V
E
N
Q
VT
Y
PLT
TT
M
LS
V
P
G
AK
T
VRG
F
S
QF-
G
DSY
VYV
I
FE
D
GT
D
P
Y
W
A
RS
R
V
L
EY
L
N
Q
V
QGK
LP
A-----
GV
SAELGPDAT
GVG
W
I
YEY
A
LV
D
RSGKHDLA
D
L
R
S
L
Q
DWF
L
KYE
L
K
TIP
D
V
A
E
V
ASV
G
GVVKEY
QV
V
I
DP
QR
L
A
QYG
I
SLAE
V
KS
A
L
DAS
N
QEAGG
SSI
--
-
-
--ELAEAEYM
V
R
A
SGY
LQT
L
D
D
F
NH
I
V
L
KASE
N
G
VP
V
Y
L
R
DVA
K
V
Q
I
G
P
E
MRRGI
A
EL
NG
E
G
E
V
A
G
GV
V
I
L
RS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSS
L
P
E
GV
E
IVTT
YD
RS
QL
I
DR
A
I
D
N
LSGK
L
L
E
EF
I
V
V
A
V
V
C
A
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
I
V
M
H
F
Q
G
L
N
A
N
I
MSL
G
G
I
A
I
A
V
G
A
M
VD
A
AIV
MI
EN
AH
K
R
L
E
E
WQHQHPDATL
D
NKT
R
WQ
V
IT
D
ASV
EVG
P
AL
FISLLI
I
T
LS
FIP
I
F
T
LE
G
QE
G
R
LFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------L
N
RF
L
IRV---
----
Y
HPLLL
KVL
HWPKTT
L
L
V
A
A
L
SVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TD
K
--
LIMSVPE
V
A
R
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMD
K
II
E
EL
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LST
G
IK
S
PIGIK
V
SGTVLADI
D
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
LE
GGRYIN
V
E
IN
RE
KA
A
R
Y
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DS
P
QA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DIKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YI
D
A
RDRD
M
V
S
V
V
HDLQKAIAEK
V
Q
LK
P
G
TSVA
F
S
G
--
-Q
FE
LL
E
RANHKLK
L
M
VP
M
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAI
E
AV
PSLNNPQTFSE
QKLD
EA
LYH
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
GAGS
E
VMSR
I
A
A
PM
I
GGM
IT
A
P
LL
S
L
F
II
P
AA
Y
K
L
M
WLHRHRVRK
fig|481805.3.peg.3294
Escherichia coli ATCC 8739
MIEWIIRR
S
VA
NRF
L
VLMG
A
L
F
L
S
I
W
G
TWT
I
IN
T
PV
D
AL
P
D
L
SD
V
Q
V
I
I
K
T
S
YPG
Q
A
P
Q
I
V
E
N
Q
VT
Y
PLT
TT
M
LS
V
P
G
AK
T
VRG
F
S
QF-
G
DSY
VYV
I
FE
D
GT
D
P
Y
W
A
RS
R
V
L
EY
L
N
Q
V
QGK
LP
A-----
GV
SAELGPDAT
GVG
W
I
YEY
A
LV
D
RSGKHDLA
D
L
R
S
L
Q
DWF
L
KYE
L
K
TIP
D
V
A
E
V
ASV
G
GVVKEY
QV
V
I
DP
QR
L
A
QYG
I
SLAE
V
KS
A
L
DAS
N
QEAGG
SSI
--
-
-
--ELAEAEYM
V
R
A
SGY
LQT
L
D
D
F
NH
I
V
L
KASE
N
G
VP
V
Y
L
R
DVA
K
V
Q
I
G
P
E
MRRGI
A
EL
NG
E
G
E
V
A
G
GV
V
I
L
RS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSS
L
P
E
GV
E
IVTT
YD
RS
QL
I
DR
A
I
D
N
LSGK
L
L
E
EF
I
V
V
A
V
V
C
A
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
I
V
M
H
F
Q
G
L
N
A
N
I
MSL
G
G
I
A
I
A
V
G
A
M
VD
A
AIV
MI
EN
AH
K
R
L
E
E
WQHQHPDATL
D
NKT
R
WQ
V
IT
D
ASV
EVG
P
AL
FISLLI
I
T
LS
FIP
I
F
T
LE
G
QE
G
R
LFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------L
N
RF
L
IRV---
----
Y
HPLLL
KVL
HWPKTT
L
L
V
A
A
L
SVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TD
K
--
LIMSVPE
V
A
R
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMD
K
II
E
EL
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LST
G
IK
S
PIGIK
V
SGTVLADI
D
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
LE
GGRYIN
V
E
IN
RE
KA
A
R
Y
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DS
P
QA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DIKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YI
D
A
RDRD
M
V
S
V
V
HDLQKAIAEK
V
Q
LK
P
G
TSVA
F
S
G
--
-Q
FE
LL
E
RANHKLK
L
M
VP
M
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAI
E
AV
PSLNNPQTFSE
QKLD
EA
LYH
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
GAGS
E
VMSR
I
A
A
PM
I
GGM
IT
A
P
LL
S
L
F
II
P
AA
Y
K
L
M
WLHRHRVRK
fig|481805.6.peg.3280
Escherichia coli ATCC 8739
MIEWIIRR
S
VA
NRF
L
VLMG
A
L
F
L
S
I
W
G
TWT
I
IN
T
PV
D
AL
P
D
L
SD
V
Q
V
I
I
K
T
S
YPG
Q
A
P
Q
I
V
E
N
Q
VT
Y
PLT
TT
M
LS
V
P
G
AK
T
VRG
F
S
QF-
G
DSY
VYV
I
FE
D
GT
D
P
Y
W
A
RS
R
V
L
EY
L
N
Q
V
QGK
LP
A-----
GV
SAELGPDAT
GVG
W
I
YEY
A
LV
D
RSGKHDLA
D
L
R
S
L
Q
DWF
L
KYE
L
K
TIP
D
V
A
E
V
ASV
G
GVVKEY
QV
V
I
DP
QR
L
A
QYG
I
SLAE
V
KS
A
L
DAS
N
QEAGG
SSI
--
-
-
--ELAEAEYM
V
R
A
SGY
LQT
L
D
D
F
NH
I
V
L
KASE
N
G
VP
V
Y
L
R
DVA
K
V
Q
I
G
P
E
MRRGI
A
EL
NG
E
G
E
V
A
G
GV
V
I
L
RS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSS
L
P
E
GV
E
IVTT
YD
RS
QL
I
DR
A
I
D
N
LSGK
L
L
E
EF
I
V
V
A
V
V
C
A
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
I
V
M
H
F
Q
G
L
N
A
N
I
MSL
G
G
I
A
I
A
V
G
A
M
VD
A
AIV
MI
EN
AH
K
R
L
E
E
WQHQHPDATL
D
NKT
R
WQ
V
IT
D
ASV
EVG
P
AL
FISLLI
I
T
LS
FIP
I
F
T
LE
G
QE
G
R
LFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------L
N
RF
L
IRV---
----
Y
HPLLL
KVL
HWPKTT
L
L
V
A
A
L
SVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TD
K
--
LIMSVPE
V
A
R
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMD
K
II
E
EL
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LST
G
IK
S
PIGIK
V
SGTVLADI
D
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
LE
GGRYIN
V
E
IN
RE
KA
A
R
Y
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DS
P
QA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DIKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YI
D
A
RDRD
M
V
S
V
V
HDLQKAIAEK
V
Q
LK
P
G
TSVA
F
S
G
--
-Q
FE
LL
E
RANHKLK
L
M
VP
M
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAI
E
AV
PSLNNPQTFSE
QKLD
EA
LYH
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
GAGS
E
VMSR
I
A
A
PM
I
GGM
IT
A
P
LL
S
L
F
II
P
AA
Y
K
L
M
WLHRHRVRK
fig|550672.3.peg.142
Escherichia coli B088
MIEWIIRR
S
VA
NRF
L
VLMG
A
L
F
L
S
I
W
G
TWT
I
IN
T
PV
D
AL
P
D
L
SD
V
Q
V
I
I
K
T
S
YPG
Q
A
P
Q
I
V
E
N
Q
VT
Y
PLT
TT
M
LS
V
P
G
AK
T
VRG
F
S
QF-
G
DSY
VYV
I
FE
D
GT
D
P
Y
W
A
RS
R
V
L
EY
L
N
Q
V
QGK
LP
A-----
GV
SAELGPDAT
GVG
W
I
YEY
A
LV
D
RSGKHDLA
D
L
R
S
L
Q
DWF
L
KYE
L
K
TIP
D
V
A
E
V
ASV
G
GVVKEY
QV
V
I
DP
QR
L
A
QYG
I
SLAE
V
KS
A
L
DAS
N
QEAGG
SSI
--
-
-
--ELAEAEYM
V
R
A
SGY
LQT
L
D
D
F
NH
I
V
L
KASE
N
G
VP
V
Y
L
R
DVA
K
V
Q
I
G
P
E
MRRGI
A
EL
NG
E
G
E
V
A
G
GV
V
I
L
RS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSS
L
P
E
GV
E
IVTT
YD
RS
QL
I
DR
A
I
D
N
LSGK
L
L
E
EF
I
V
V
A
V
V
C
A
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
I
V
M
H
F
Q
G
L
N
A
N
I
MSL
G
G
I
A
I
A
V
G
A
M
VD
A
AIV
MI
EN
AH
K
R
L
E
E
WQHQHPDATL
D
NKT
R
WQ
V
IT
D
ASV
EVG
P
AL
FISLLI
I
T
LS
FIP
I
F
T
LE
G
QE
G
R
LFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------L
N
RF
L
IRV---
----
Y
HPLLL
KVL
HWPKTT
L
L
V
A
A
L
SVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TD
K
--
LIMSVPE
V
A
R
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMD
K
II
E
EL
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LST
G
IK
S
PIGIK
V
SGTVLADI
D
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
LE
GGRYIN
V
E
IN
RE
KA
A
R
Y
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DS
P
QA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DIKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YI
D
A
RDRD
M
V
S
V
V
HDLQKAIAEK
V
Q
LK
P
G
TSVA
F
S
G
--
-Q
FE
LL
E
RANHKLK
L
M
VP
M
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAI
E
AV
PSLNNPQTFSE
QKLD
EA
LYH
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
GAGS
E
VMSR
I
A
A
PM
I
GGM
IT
A
P
LL
S
L
F
II
P
AA
Y
K
L
M
WLHRHRVRK
fig|595496.3.peg.496
Escherichia coli BW2952
MIEWIIRR
S
VA
NRF
L
VLMG
A
L
F
L
S
I
W
G
TWT
I
IN
T
PV
D
AL
P
D
L
SD
V
Q
V
I
I
K
T
S
YPG
Q
A
P
Q
I
V
E
N
Q
VT
Y
PLT
TT
M
LS
V
P
G
AK
T
VRG
F
S
QF-
G
DSY
VYV
I
FE
D
GT
D
P
Y
W
A
RS
R
V
L
EY
L
N
Q
V
QGK
LP
A-----
GV
SAELGPDAT
GVG
W
I
YEY
A
LV
D
RSGKHDLA
D
L
R
S
L
Q
DWF
L
KYE
L
K
TIP
D
V
A
E
V
ASV
G
GVVKEY
QV
V
I
DP
QR
L
A
QYG
I
SLAE
V
KS
A
L
DAS
N
QEAGG
SSI
--
-
-
--ELAEAEYM
V
R
A
SGY
LQT
L
D
D
F
NH
I
V
L
KASE
N
G
VP
V
Y
L
R
DVA
K
V
Q
I
G
P
E
MRRGI
A
EL
NG
E
G
E
V
A
G
GV
V
I
L
RS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSS
L
P
E
GV
E
IVTT
YD
RS
QL
I
DR
A
I
D
N
LSGK
L
L
E
EF
I
V
V
A
V
V
C
A
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
I
V
M
H
F
Q
G
L
N
A
N
I
MSL
G
G
I
A
I
A
V
G
A
M
VD
A
AIV
MI
EN
AH
K
R
L
E
E
WQHQHPDATL
D
NKT
R
WQ
V
IT
D
ASV
EVG
P
AL
FISLLI
I
T
LS
FIP
I
F
T
LE
G
QE
G
R
LFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------L
N
RF
L
IRV---
----
Y
HPLLL
KVL
HWPKTT
L
L
V
A
A
L
SVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TD
K
--
LIMSVPE
V
A
R
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMD
K
II
E
EL
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LST
G
IK
S
PIGIK
V
SGTVLADI
D
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
LE
GGRYIN
V
E
IN
RE
KA
A
R
Y
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DS
P
QA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DIKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YI
D
A
RDRD
M
V
S
V
V
HDLQKAIAEK
V
Q
LK
P
G
TSVA
F
S
G
--
-Q
FE
LL
E
RANHKLK
L
M
VP
M
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAI
E
AV
PSLNNPQTFSE
QKLD
EA
LYH
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
GAGS
E
VMSR
I
A
A
PM
I
GGM
IT
A
P
LL
S
L
F
II
P
AA
Y
K
L
M
WLHRHRVRK
fig|536056.3.peg.3227
Escherichia coli DH1
MIEWIIRR
S
VA
NRF
L
VLMG
A
L
F
L
S
I
W
G
TWT
I
IN
T
PV
D
AL
P
D
L
SD
V
Q
V
I
I
K
T
S
YPG
Q
A
P
Q
I
V
E
N
Q
VT
Y
PLT
TT
M
LS
V
P
G
AK
T
VRG
F
S
QF-
G
DSY
VYV
I
FE
D
GT
D
P
Y
W
A
RS
R
V
L
EY
L
N
Q
V
QGK
LP
A-----
GV
SAELGPDAT
GVG
W
I
YEY
A
LV
D
RSGKHDLA
D
L
R
S
L
Q
DWF
L
KYE
L
K
TIP
D
V
A
E
V
ASV
G
GVVKEY
QV
V
I
DP
QR
L
A
QYG
I
SLAE
V
KS
A
L
DAS
N
QEAGG
SSI
--
-
-
--ELAEAEYM
V
R
A
SGY
LQT
L
D
D
F
NH
I
V
L
KASE
N
G
VP
V
Y
L
R
DVA
K
V
Q
I
G
P
E
MRRGI
A
EL
NG
E
G
E
V
A
G
GV
V
I
L
RS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSS
L
P
E
GV
E
IVTT
YD
RS
QL
I
DR
A
I
D
N
LSGK
L
L
E
EF
I
V
V
A
V
V
C
A
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
I
V
M
H
F
Q
G
L
N
A
N
I
MSL
G
G
I
A
I
A
V
G
A
M
VD
A
AIV
MI
EN
AH
K
R
L
E
E
WQHQHPDATL
D
NKT
R
WQ
V
IT
D
ASV
EVG
P
AL
FISLLI
I
T
LS
FIP
I
F
T
LE
G
QE
G
R
LFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------L
N
RF
L
IRV---
----
Y
HPLLL
KVL
HWPKTT
L
L
V
A
A
L
SVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TD
K
--
LIMSVPE
V
A
R
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMD
K
II
E
EL
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LST
G
IK
S
PIGIK
V
SGTVLADI
D
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
LE
GGRYIN
V
E
IN
RE
KA
A
R
Y
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DS
P
QA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DIKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YI
D
A
RDRD
M
V
S
V
V
HDLQKAIAEK
V
Q
LK
P
G
TSVA
F
S
G
--
-Q
FE
LL
E
RANHKLK
L
M
VP
M
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAI
E
AV
PSLNNPQTFSE
QKLD
EA
LYH
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
GAGS
E
VMSR
I
A
A
PM
I
GGM
IT
A
P
LL
S
L
F
II
P
AA
Y
K
L
M
WLHRHRVRK
fig|340185.3.peg.1764
Escherichia coli E22
MIEWIIRR
S
VA
NRF
L
VLMG
A
L
F
L
S
I
W
G
TWT
I
IN
T
PV
D
AL
P
D
L
SD
V
Q
V
I
I
K
T
S
YPG
Q
A
P
Q
I
V
E
N
Q
VT
Y
PLT
TT
M
LS
V
P
G
AK
T
VRG
F
S
QF-
G
DSY
VYV
I
FE
D
GT
D
P
Y
W
A
RS
R
V
L
EY
L
N
Q
V
QGK
LP
A-----
GV
SAELGPDAT
GVG
W
I
YEY
A
LV
D
RSGKHDLA
D
L
R
S
L
Q
DWF
L
KYE
L
K
TIP
D
V
A
E
V
ASV
G
GVVKEY
QV
V
I
DP
QR
L
A
QYG
I
SLAE
V
KS
A
L
DAS
N
QEAGG
SSI
--
-
-
--ELAEAEYM
V
R
A
SGY
LQT
L
D
D
F
NH
I
V
L
KASE
N
G
VP
V
Y
L
R
DVA
K
V
Q
I
G
P
E
MRRGI
A
EL
NG
E
G
E
V
A
G
GV
V
I
L
RS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSS
L
P
E
GV
E
IVTT
YD
RS
QL
I
DR
A
I
D
N
LSGK
L
L
E
EF
I
V
V
A
V
V
C
A
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
I
V
M
H
F
Q
G
L
N
A
N
I
MSL
G
G
I
A
I
A
V
G
A
M
VD
A
AIV
MI
EN
AH
K
R
L
E
E
WQHQHPDATL
D
NKT
R
WQ
V
IT
D
ASV
EVG
P
AL
FISLLI
I
T
LS
FIP
I
F
T
LE
G
QE
G
R
LFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------L
N
RF
L
IRV---
----
Y
HPLLL
KVL
HWPKTT
L
L
V
A
A
L
SVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TD
K
--
LIMSVPE
V
A
R
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMD
K
II
E
EL
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LST
G
IK
S
PIGIK
V
SGTVLADI
D
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
LE
GGRYIN
V
E
IN
RE
KA
A
R
Y
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DS
P
QA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DIKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YI
D
A
RDRD
M
V
S
V
V
HDLQKAIAEK
V
Q
LK
P
G
TSVA
F
S
G
--
-Q
FE
LL
E
RANHKLK
L
M
VP
M
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAI
E
AV
PSLNNPQTFSE
QKLD
EA
LYH
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
GAGS
E
VMSR
I
A
A
PM
I
GGM
IT
A
P
LL
S
L
F
II
P
AA
Y
K
L
M
WLHRHRVRK
fig|340185.4.peg.1859
Escherichia coli E22
MIEWIIRR
S
VA
NRF
L
VLMG
A
L
F
L
S
I
W
G
TWT
I
IN
T
PV
D
AL
P
D
L
SD
V
Q
V
I
I
K
T
S
YPG
Q
A
P
Q
I
V
E
N
Q
VT
Y
PLT
TT
M
LS
V
P
G
AK
T
VRG
F
S
QF-
G
DSY
VYV
I
FE
D
GT
D
P
Y
W
A
RS
R
V
L
EY
L
N
Q
V
QGK
LP
A-----
GV
SAELGPDAT
GVG
W
I
YEY
A
LV
D
RSGKHDLA
D
L
R
S
L
Q
DWF
L
KYE
L
K
TIP
D
V
A
E
V
ASV
G
GVVKEY
QV
V
I
DP
QR
L
A
QYG
I
SLAE
V
KS
A
L
DAS
N
QEAGG
SSI
--
-
-
--ELAEAEYM
V
R
A
SGY
LQT
L
D
D
F
NH
I
V
L
KASE
N
G
VP
V
Y
L
R
DVA
K
V
Q
I
G
P
E
MRRGI
A
EL
NG
E
G
E
V
A
G
GV
V
I
L
RS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSS
L
P
E
GV
E
IVTT
YD
RS
QL
I
DR
A
I
D
N
LSGK
L
L
E
EF
I
V
V
A
V
V
C
A
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
I
V
M
H
F
Q
G
L
N
A
N
I
MSL
G
G
I
A
I
A
V
G
A
M
VD
A
AIV
MI
EN
AH
K
R
L
E
E
WQHQHPDATL
D
NKT
R
WQ
V
IT
D
ASV
EVG
P
AL
FISLLI
I
T
LS
FIP
I
F
T
LE
G
QE
G
R
LFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------L
N
RF
L
IRV---
----
Y
HPLLL
KVL
HWPKTT
L
L
V
A
A
L
SVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TD
K
--
LIMSVPE
V
A
R
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMD
K
II
E
EL
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LST
G
IK
S
PIGIK
V
SGTVLADI
D
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
LE
GGRYIN
V
E
IN
RE
KA
A
R
Y
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DS
P
QA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DIKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YI
D
A
RDRD
M
V
S
V
V
HDLQKAIAEK
V
Q
LK
P
G
TSVA
F
S
G
--
-Q
FE
LL
E
RANHKLK
L
M
VP
M
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAI
E
AV
PSLNNPQTFSE
QKLD
EA
LYH
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
GAGS
E
VMSR
I
A
A
PM
I
GGM
IT
A
P
LL
S
L
F
II
P
AA
Y
K
L
M
WLHRHRVRK
fig|331112.3.peg.579
Escherichia coli HS
MIEWIIRR
S
VA
NRF
L
VLMG
A
L
F
L
S
I
W
G
TWT
I
IN
T
PV
D
AL
P
D
L
SD
V
Q
V
I
I
K
T
S
YPG
Q
A
P
Q
I
V
E
N
Q
VT
Y
PLT
TT
M
LS
V
P
G
AK
T
VRG
F
S
QF-
G
DSY
VYV
I
FE
D
GT
D
P
Y
W
A
RS
R
V
L
EY
L
N
Q
V
QGK
LP
A-----
GV
SAELGPDAT
GVG
W
I
YEY
A
LV
D
RSGKHDLA
D
L
R
S
L
Q
DWF
L
KYE
L
K
TIP
D
V
A
E
V
ASV
G
GVVKEY
QV
V
I
DP
QR
L
A
QYG
I
SLAE
V
KS
A
L
DAS
N
QEAGG
SSI
--
-
-
--ELAEAEYM
V
R
A
SGY
LQT
L
D
D
F
NH
I
V
L
KASE
N
G
VP
V
Y
L
R
DVA
K
V
Q
I
G
P
E
MRRGI
A
EL
NG
E
G
E
V
A
G
GV
V
I
L
RS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSS
L
P
E
GV
E
IVTT
YD
RS
QL
I
DR
A
I
D
N
LSGK
L
L
E
EF
I
V
V
A
V
V
C
A
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
I
V
M
H
F
Q
G
L
N
A
N
I
MSL
G
G
I
A
I
A
V
G
A
M
VD
A
AIV
MI
EN
AH
K
R
L
E
E
WQHQHPDATL
D
NKT
R
WQ
V
IT
D
ASV
EVG
P
AL
FISLLI
I
T
LS
FIP
I
F
T
LE
G
QE
G
R
LFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------L
N
RF
L
IRV---
----
Y
HPLLL
KVL
HWPKTT
L
L
V
A
A
L
SVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TD
K
--
LIMSVPE
V
A
R
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMD
K
II
E
EL
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LST
G
IK
S
PIGIK
V
SGTVLADI
D
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
LE
GGRYIN
V
E
IN
RE
KA
A
R
Y
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DS
P
QA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DIKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YI
D
A
RDRD
M
V
S
V
V
HDLQKAIAEK
V
Q
LK
P
G
TSVA
F
S
G
--
-Q
FE
LL
E
RANHKLK
L
M
VP
M
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAI
E
AV
PSLNNPQTFSE
QKLD
EA
LYH
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
GAGS
E
VMSR
I
A
A
PM
I
GGM
IT
A
P
LL
S
L
F
II
P
AA
Y
K
L
M
WLHRHRVRK
fig|331112.6.peg.606
Escherichia coli HS
MIEWIIRR
S
VA
NRF
L
VLMG
A
L
F
L
S
I
W
G
TWT
I
IN
T
PV
D
AL
P
D
L
SD
V
Q
V
I
I
K
T
S
YPG
Q
A
P
Q
I
V
E
N
Q
VT
Y
PLT
TT
M
LS
V
P
G
AK
T
VRG
F
S
QF-
G
DSY
VYV
I
FE
D
GT
D
P
Y
W
A
RS
R
V
L
EY
L
N
Q
V
QGK
LP
A-----
GV
SAELGPDAT
GVG
W
I
YEY
A
LV
D
RSGKHDLA
D
L
R
S
L
Q
DWF
L
KYE
L
K
TIP
D
V
A
E
V
ASV
G
GVVKEY
QV
V
I
DP
QR
L
A
QYG
I
SLAE
V
KS
A
L
DAS
N
QEAGG
SSI
--
-
-
--ELAEAEYM
V
R
A
SGY
LQT
L
D
D
F
NH
I
V
L
KASE
N
G
VP
V
Y
L
R
DVA
K
V
Q
I
G
P
E
MRRGI
A
EL
NG
E
G
E
V
A
G
GV
V
I
L
RS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSS
L
P
E
GV
E
IVTT
YD
RS
QL
I
DR
A
I
D
N
LSGK
L
L
E
EF
I
V
V
A
V
V
C
A
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
I
V
M
H
F
Q
G
L
N
A
N
I
MSL
G
G
I
A
I
A
V
G
A
M
VD
A
AIV
MI
EN
AH
K
R
L
E
E
WQHQHPDATL
D
NKT
R
WQ
V
IT
D
ASV
EVG
P
AL
FISLLI
I
T
LS
FIP
I
F
T
LE
G
QE
G
R
LFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------L
N
RF
L
IRV---
----
Y
HPLLL
KVL
HWPKTT
L
L
V
A
A
L
SVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TD
K
--
LIMSVPE
V
A
R
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMD
K
II
E
EL
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LST
G
IK
S
PIGIK
V
SGTVLADI
D
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
LE
GGRYIN
V
E
IN
RE
KA
A
R
Y
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DS
P
QA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DIKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YI
D
A
RDRD
M
V
S
V
V
HDLQKAIAEK
V
Q
LK
P
G
TSVA
F
S
G
--
-Q
FE
LL
E
RANHKLK
L
M
VP
M
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAI
E
AV
PSLNNPQTFSE
QKLD
EA
LYH
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
GAGS
E
VMSR
I
A
A
PM
I
GGM
IT
A
P
LL
S
L
F
II
P
AA
Y
K
L
M
WLHRHRVRK
fig|585034.4.peg.550
Escherichia coli IAI1
MIEWIIRR
S
VA
NRF
L
VLMG
A
L
F
L
S
I
W
G
TWT
I
IN
T
PV
D
AL
P
D
L
SD
V
Q
V
I
I
K
T
S
YPG
Q
A
P
Q
I
V
E
N
Q
VT
Y
PLT
TT
M
LS
V
P
G
AK
T
VRG
F
S
QF-
G
DSY
VYV
I
FE
D
GT
D
P
Y
W
A
RS
R
V
L
EY
L
N
Q
V
QGK
LP
A-----
GV
SAELGPDAT
GVG
W
I
YEY
A
LV
D
RSGKHDLA
D
L
R
S
L
Q
DWF
L
KYE
L
K
TIP
D
V
A
E
V
ASV
G
GVVKEY
QV
V
I
DP
QR
L
A
QYG
I
SLAE
V
KS
A
L
DAS
N
QEAGG
SSI
--
-
-
--ELAEAEYM
V
R
A
SGY
LQT
L
D
D
F
NH
I
V
L
KASE
N
G
VP
V
Y
L
R
DVA
K
V
Q
I
G
P
E
MRRGI
A
EL
NG
E
G
E
V
A
G
GV
V
I
L
RS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSS
L
P
E
GV
E
IVTT
YD
RS
QL
I
DR
A
I
D
N
LSGK
L
L
E
EF
I
V
V
A
V
V
C
A
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
I
V
M
H
F
Q
G
L
N
A
N
I
MSL
G
G
I
A
I
A
V
G
A
M
VD
A
AIV
MI
EN
AH
K
R
L
E
E
WQHQHPDATL
D
NKT
R
WQ
V
IT
D
ASV
EVG
P
AL
FISLLI
I
T
LS
FIP
I
F
T
LE
G
QE
G
R
LFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------L
N
RF
L
IRV---
----
Y
HPLLL
KVL
HWPKTT
L
L
V
A
A
L
SVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TD
K
--
LIMSVPE
V
A
R
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMD
K
II
E
EL
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LST
G
IK
S
PIGIK
V
SGTVLADI
D
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
LE
GGRYIN
V
E
IN
RE
KA
A
R
Y
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DS
P
QA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DIKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YI
D
A
RDRD
M
V
S
V
V
HDLQKAIAEK
V
Q
LK
P
G
TSVA
F
S
G
--
-Q
FE
LL
E
RANHKLK
L
M
VP
M
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAI
E
AV
PSLNNPQTFSE
QKLD
EA
LYH
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
GAGS
E
VMSR
I
A
A
PM
I
GGM
IT
A
P
LL
S
L
F
II
P
AA
Y
K
L
M
WLHRHRVRK
fig|585034.5.peg.549
Escherichia coli IAI1
MIEWIIRR
S
VA
NRF
L
VLMG
A
L
F
L
S
I
W
G
TWT
I
IN
T
PV
D
AL
P
D
L
SD
V
Q
V
I
I
K
T
S
YPG
Q
A
P
Q
I
V
E
N
Q
VT
Y
PLT
TT
M
LS
V
P
G
AK
T
VRG
F
S
QF-
G
DSY
VYV
I
FE
D
GT
D
P
Y
W
A
RS
R
V
L
EY
L
N
Q
V
QGK
LP
A-----
GV
SAELGPDAT
GVG
W
I
YEY
A
LV
D
RSGKHDLA
D
L
R
S
L
Q
DWF
L
KYE
L
K
TIP
D
V
A
E
V
ASV
G
GVVKEY
QV
V
I
DP
QR
L
A
QYG
I
SLAE
V
KS
A
L
DAS
N
QEAGG
SSI
--
-
-
--ELAEAEYM
V
R
A
SGY
LQT
L
D
D
F
NH
I
V
L
KASE
N
G
VP
V
Y
L
R
DVA
K
V
Q
I
G
P
E
MRRGI
A
EL
NG
E
G
E
V
A
G
GV
V
I
L
RS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSS
L
P
E
GV
E
IVTT
YD
RS
QL
I
DR
A
I
D
N
LSGK
L
L
E
EF
I
V
V
A
V
V
C
A
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
I
V
M
H
F
Q
G
L
N
A
N
I
MSL
G
G
I
A
I
A
V
G
A
M
VD
A
AIV
MI
EN
AH
K
R
L
E
E
WQHQHPDATL
D
NKT
R
WQ
V
IT
D
ASV
EVG
P
AL
FISLLI
I
T
LS
FIP
I
F
T
LE
G
QE
G
R
LFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------L
N
RF
L
IRV---
----
Y
HPLLL
KVL
HWPKTT
L
L
V
A
A
L
SVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TD
K
--
LIMSVPE
V
A
R
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMD
K
II
E
EL
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LST
G
IK
S
PIGIK
V
SGTVLADI
D
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
LE
GGRYIN
V
E
IN
RE
KA
A
R
Y
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DS
P
QA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DIKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YI
D
A
RDRD
M
V
S
V
V
HDLQKAIAEK
V
Q
LK
P
G
TSVA
F
S
G
--
-Q
FE
LL
E
RANHKLK
L
M
VP
M
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAI
E
AV
PSLNNPQTFSE
QKLD
EA
LYH
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
GAGS
E
VMSR
I
A
A
PM
I
GGM
IT
A
P
LL
S
L
F
II
P
AA
Y
K
L
M
WLHRHRVRK
fig|83333.1.peg.573
Escherichia coli K12
MIEWIIRR
S
VA
NRF
L
VLMG
A
L
F
L
S
I
W
G
TWT
I
IN
T
PV
D
AL
P
D
L
SD
V
Q
V
I
I
K
T
S
YPG
Q
A
P
Q
I
V
E
N
Q
VT
Y
PLT
TT
M
LS
V
P
G
AK
T
VRG
F
S
QF-
G
DSY
VYV
I
FE
D
GT
D
P
Y
W
A
RS
R
V
L
EY
L
N
Q
V
QGK
LP
A-----
GV
SAELGPDAT
GVG
W
I
YEY
A
LV
D
RSGKHDLA
D
L
R
S
L
Q
DWF
L
KYE
L
K
TIP
D
V
A
E
V
ASV
G
GVVKEY
QV
V
I
DP
QR
L
A
QYG
I
SLAE
V
KS
A
L
DAS
N
QEAGG
SSI
--
-
-
--ELAEAEYM
V
R
A
SGY
LQT
L
D
D
F
NH
I
V
L
KASE
N
G
VP
V
Y
L
R
DVA
K
V
Q
I
G
P
E
MRRGI
A
EL
NG
E
G
E
V
A
G
GV
V
I
L
RS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSS
L
P
E
GV
E
IVTT
YD
RS
QL
I
DR
A
I
D
N
LSGK
L
L
E
EF
I
V
V
A
V
V
C
A
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
I
V
M
H
F
Q
G
L
N
A
N
I
MSL
G
G
I
A
I
A
V
G
A
M
VD
A
AIV
MI
EN
AH
K
R
L
E
E
WQHQHPDATL
D
NKT
R
WQ
V
IT
D
ASV
EVG
P
AL
FISLLI
I
T
LS
FIP
I
F
T
LE
G
QE
G
R
LFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------L
N
RF
L
IRV---
----
Y
HPLLL
KVL
HWPKTT
L
L
V
A
A
L
SVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TD
K
--
LIMSVPE
V
A
R
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMD
K
II
E
EL
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LST
G
IK
S
PIGIK
V
SGTVLADI
D
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
LE
GGRYIN
V
E
IN
RE
KA
A
R
Y
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DS
P
QA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DIKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YI
D
A
RDRD
M
V
S
V
V
HDLQKAIAEK
V
Q
LK
P
G
TSVA
F
S
G
--
-Q
FE
LL
E
RANHKLK
L
M
VP
M
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAI
E
AV
PSLNNPQTFSE
QKLD
EA
LYH
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
GAGS
E
VMSR
I
A
A
PM
I
GGM
IT
A
P
LL
S
L
F
II
P
AA
Y
K
L
M
WLHRHRVRK
fig|749538.3.peg.2539
Escherichia coli MS 116-1
MIEWIIRR
S
VA
NRF
L
VLMG
A
L
F
L
S
I
W
G
TWT
I
IN
T
PV
D
AL
P
D
L
SD
V
Q
V
I
I
K
T
S
YPG
Q
A
P
Q
I
V
E
N
Q
VT
Y
PLT
TT
M
LS
V
P
G
AK
T
VRG
F
S
QF-
G
DSY
VYV
I
FE
D
GT
D
P
Y
W
A
RS
R
V
L
EY
L
N
Q
V
QGK
LP
A-----
GV
SAELGPDAT
GVG
W
I
YEY
A
LV
D
RSGKHDLA
D
L
R
S
L
Q
DWF
L
KYE
L
K
TIP
D
V
A
E
V
ASV
G
GVVKEY
QV
V
I
DP
QR
L
A
QYG
I
SLAE
V
KS
A
L
DAS
N
QEAGG
SSI
--
-
-
--ELAEAEYM
V
R
A
SGY
LQT
L
D
D
F
NH
I
V
L
KASE
N
G
VP
V
Y
L
R
DVA
K
V
Q
I
G
P
E
MRRGI
A
EL
NG
E
G
E
V
A
G
GV
V
I
L
RS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSS
L
P
E
GV
E
IVTT
YD
RS
QL
I
DR
A
I
D
N
LSGK
L
L
E
EF
I
V
V
A
V
V
C
A
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
I
V
M
H
F
Q
G
L
N
A
N
I
MSL
G
G
I
A
I
A
V
G
A
M
VD
A
AIV
MI
EN
AH
K
R
L
E
E
WQHQHPDATL
D
NKT
R
WQ
V
IT
D
ASV
EVG
P
AL
FISLLI
I
T
LS
FIP
I
F
T
LE
G
QE
G
R
LFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------L
N
RF
L
IRV---
----
Y
HPLLL
KVL
HWPKTT
L
L
V
A
A
L
SVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TD
K
--
LIMSVPE
V
A
R
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMD
K
II
E
EL
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LST
G
IK
S
PIGIK
V
SGTVLADI
D
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
LE
GGRYIN
V
E
IN
RE
KA
A
R
Y
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DS
P
QA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DIKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YI
D
A
RDRD
M
V
S
V
V
HDLQKAIAEK
V
Q
LK
P
G
TSVA
F
S
G
--
-Q
FE
LL
E
RANHKLK
L
M
VP
M
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAI
E
AV
PSLNNPQTFSE
QKLD
EA
LYH
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
GAGS
E
VMSR
I
A
A
PM
I
GGM
IT
A
P
LL
S
L
F
II
P
AA
Y
K
L
M
WLHRHRVRK
fig|679205.4.peg.578
Escherichia coli MS 124-1
MIEWIIRR
S
VA
NRF
L
VLMG
A
L
F
L
S
I
W
G
TWT
I
IN
T
PV
D
AL
P
D
L
SD
V
Q
V
I
I
K
T
S
YPG
Q
A
P
Q
I
V
E
N
Q
VT
Y
PLT
TT
M
LS
V
P
G
AK
T
VRG
F
S
QF-
G
DSY
VYV
I
FE
D
GT
D
P
Y
W
A
RS
R
V
L
EY
L
N
Q
V
QGK
LP
A-----
GV
SAELGPDAT
GVG
W
I
YEY
A
LV
D
RSGKHDLA
D
L
R
S
L
Q
DWF
L
KYE
L
K
TIP
D
V
A
E
V
ASV
G
GVVKEY
QV
V
I
DP
QR
L
A
QYG
I
SLAE
V
KS
A
L
DAS
N
QEAGG
SSI
--
-
-
--ELAEAEYM
V
R
A
SGY
LQT
L
D
D
F
NH
I
V
L
KASE
N
G
VP
V
Y
L
R
DVA
K
V
Q
I
G
P
E
MRRGI
A
EL
NG
E
G
E
V
A
G
GV
V
I
L
RS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSS
L
P
E
GV
E
IVTT
YD
RS
QL
I
DR
A
I
D
N
LSGK
L
L
E
EF
I
V
V
A
V
V
C
A
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
I
V
M
H
F
Q
G
L
N
A
N
I
MSL
G
G
I
A
I
A
V
G
A
M
VD
A
AIV
MI
EN
AH
K
R
L
E
E
WQHQHPDATL
D
NKT
R
WQ
V
IT
D
ASV
EVG
P
AL
FISLLI
I
T
LS
FIP
I
F
T
LE
G
QE
G
R
LFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------L
N
RF
L
IRV---
----
Y
HPLLL
KVL
HWPKTT
L
L
V
A
A
L
SVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TD
K
--
LIMSVPE
V
A
R
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMD
K
II
E
EL
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LST
G
IK
S
PIGIK
V
SGTVLADI
D
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
LE
GGRYIN
V
E
IN
RE
KA
A
R
Y
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DS
P
QA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DIKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YI
D
A
RDRD
M
V
S
V
V
HDLQKAIAEK
V
Q
LK
P
G
TSVA
F
S
G
--
-Q
FE
LL
E
RANHKLK
L
M
VP
M
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAI
E
AV
PSLNNPQTFSE
QKLD
EA
LYH
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
GAGS
E
VMSR
I
A
A
PM
I
GGM
IT
A
P
LL
S
L
F
II
P
AA
Y
K
L
M
WLHRHRVRK
fig|749544.3.peg.295
Escherichia coli MS 175-1
MIEWIIRR
S
VA
NRF
L
VLMG
A
L
F
L
S
I
W
G
TWT
I
IN
T
PV
D
AL
P
D
L
SD
V
Q
V
I
I
K
T
S
YPG
Q
A
P
Q
I
V
E
N
Q
VT
Y
PLT
TT
M
LS
V
P
G
AK
T
VRG
F
S
QF-
G
DSY
VYV
I
FE
D
GT
D
P
Y
W
A
RS
R
V
L
EY
L
N
Q
V
QGK
LP
A-----
GV
SAELGPDAT
GVG
W
I
YEY
A
LV
D
RSGKHDLA
D
L
R
S
L
Q
DWF
L
KYE
L
K
TIP
D
V
A
E
V
ASV
G
GVVKEY
QV
V
I
DP
QR
L
A
QYG
I
SLAE
V
KS
A
L
DAS
N
QEAGG
SSI
--
-
-
--ELAEAEYM
V
R
A
SGY
LQT
L
D
D
F
NH
I
V
L
KASE
N
G
VP
V
Y
L
R
DVA
K
V
Q
I
G
P
E
MRRGI
A
EL
NG
E
G
E
V
A
G
GV
V
I
L
RS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSS
L
P
E
GV
E
IVTT
YD
RS
QL
I
DR
A
I
D
N
LSGK
L
L
E
EF
I
V
V
A
V
V
C
A
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
I
V
M
H
F
Q
G
L
N
A
N
I
MSL
G
G
I
A
I
A
V
G
A
M
VD
A
AIV
MI
EN
AH
K
R
L
E
E
WQHQHPDATL
D
NKT
R
WQ
V
IT
D
ASV
EVG
P
AL
FISLLI
I
T
LS
FIP
I
F
T
LE
G
QE
G
R
LFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------L
N
RF
L
IRV---
----
Y
HPLLL
KVL
HWPKTT
L
L
V
A
A
L
SVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TD
K
--
LIMSVPE
V
A
R
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMD
K
II
E
EL
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LST
G
IK
S
PIGIK
V
SGTVLADI
D
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
LE
GGRYIN
V
E
IN
RE
KA
A
R
Y
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DS
P
QA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DIKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YI
D
A
RDRD
M
V
S
V
V
HDLQKAIAEK
V
Q
LK
P
G
TSVA
F
S
G
--
-Q
FE
LL
E
RANHKLK
L
M
VP
M
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAI
E
AV
PSLNNPQTFSE
QKLD
EA
LYH
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
GAGS
E
VMSR
I
A
A
PM
I
GGM
IT
A
P
LL
S
L
F
II
P
AA
Y
K
L
M
WLHRHRVRK
fig|749548.3.peg.3348
Escherichia coli MS 196-1
MIEWIIRR
S
VA
NRF
L
VLMG
A
L
F
L
S
I
W
G
TWT
I
IN
T
PV
D
AL
P
D
L
SD
V
Q
V
I
I
K
T
S
YPG
Q
A
P
Q
I
V
E
N
Q
VT
Y
PLT
TT
M
LS
V
P
G
AK
T
VRG
F
S
QF-
G
DSY
VYV
I
FE
D
GT
D
P
Y
W
A
RS
R
V
L
EY
L
N
Q
V
QGK
LP
A-----
GV
SAELGPDAT
GVG
W
I
YEY
A
LV
D
RSGKHDLA
D
L
R
S
L
Q
DWF
L
KYE
L
K
TIP
D
V
A
E
V
ASV
G
GVVKEY
QV
V
I
DP
QR
L
A
QYG
I
SLAE
V
KS
A
L
DAS
N
QEAGG
SSI
--
-
-
--ELAEAEYM
V
R
A
SGY
LQT
L
D
D
F
NH
I
V
L
KASE
N
G
VP
V
Y
L
R
DVA
K
V
Q
I
G
P
E
MRRGI
A
EL
NG
E
G
E
V
A
G
GV
V
I
L
RS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSS
L
P
E
GV
E
IVTT
YD
RS
QL
I
DR
A
I
D
N
LSGK
L
L
E
EF
I
V
V
A
V
V
C
A
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
I
V
M
H
F
Q
G
L
N
A
N
I
MSL
G
G
I
A
I
A
V
G
A
M
VD
A
AIV
MI
EN
AH
K
R
L
E
E
WQHQHPDATL
D
NKT
R
WQ
V
IT
D
ASV
EVG
P
AL
FISLLI
I
T
LS
FIP
I
F
T
LE
G
QE
G
R
LFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------L
N
RF
L
IRV---
----
Y
HPLLL
KVL
HWPKTT
L
L
V
A
A
L
SVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TD
K
--
LIMSVPE
V
A
R
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMD
K
II
E
EL
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LST
G
IK
S
PIGIK
V
SGTVLADI
D
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
LE
GGRYIN
V
E
IN
RE
KA
A
R
Y
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DS
P
QA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DIKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YI
D
A
RDRD
M
V
S
V
V
HDLQKAIAEK
V
Q
LK
P
G
TSVA
F
S
G
--
-Q
FE
LL
E
RANHKLK
L
M
VP
M
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAI
E
AV
PSLNNPQTFSE
QKLD
EA
LYH
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
GAGS
E
VMSR
I
A
A
PM
I
GGM
IT
A
P
LL
S
L
F
II
P
AA
Y
K
L
M
WLHRHRVRK
fig|749533.3.peg.5382
Escherichia coli MS 84-1
MIEWIIRR
S
VA
NRF
L
VLMG
A
L
F
L
S
I
W
G
TWT
I
IN
T
PV
D
AL
P
D
L
SD
V
Q
V
I
I
K
T
S
YPG
Q
A
P
Q
I
V
E
N
Q
VT
Y
PLT
TT
M
LS
V
P
G
AK
T
VRG
F
S
QF-
G
DSY
VYV
I
FE
D
GT
D
P
Y
W
A
RS
R
V
L
EY
L
N
Q
V
QGK
LP
A-----
GV
SAELGPDAT
GVG
W
I
YEY
A
LV
D
RSGKHDLA
D
L
R
S
L
Q
DWF
L
KYE
L
K
TIP
D
V
A
E
V
ASV
G
GVVKEY
QV
V
I
DP
QR
L
A
QYG
I
SLAE
V
KS
A
L
DAS
N
QEAGG
SSI
--
-
-
--ELAEAEYM
V
R
A
SGY
LQT
L
D
D
F
NH
I
V
L
KASE
N
G
VP
V
Y
L
R
DVA
K
V
Q
I
G
P
E
MRRGI
A
EL
NG
E
G
E
V
A
G
GV
V
I
L
RS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSS
L
P
E
GV
E
IVTT
YD
RS
QL
I
DR
A
I
D
N
LSGK
L
L
E
EF
I
V
V
A
V
V
C
A
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
I
V
M
H
F
Q
G
L
N
A
N
I
MSL
G
G
I
A
I
A
V
G
A
M
VD
A
AIV
MI
EN
AH
K
R
L
E
E
WQHQHPDATL
D
NKT
R
WQ
V
IT
D
ASV
EVG
P
AL
FISLLI
I
T
LS
FIP
I
F
T
LE
G
QE
G
R
LFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------L
N
RF
L
IRV---
----
Y
HPLLL
KVL
HWPKTT
L
L
V
A
A
L
SVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TD
K
--
LIMSVPE
V
A
R
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMD
K
II
E
EL
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LST
G
IK
S
PIGIK
V
SGTVLADI
D
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
LE
GGRYIN
V
E
IN
RE
KA
A
R
Y
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DS
P
QA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DIKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YI
D
A
RDRD
M
V
S
V
V
HDLQKAIAEK
V
Q
LK
P
G
TSVA
F
S
G
--
-Q
FE
LL
E
RANHKLK
L
M
VP
M
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAI
E
AV
PSLNNPQTFSE
QKLD
EA
LYH
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
GAGS
E
VMSR
I
A
A
PM
I
GGM
IT
A
P
LL
S
L
F
II
P
AA
Y
K
L
M
WLHRHRVRK
fig|585395.4.peg.609
Escherichia coli O103:H2 str. 12009
MIEWIIRR
S
VA
NRF
L
VLMG
A
L
F
L
S
I
W
G
TWT
I
IN
T
PV
D
AL
P
D
L
SD
V
Q
V
I
I
K
T
S
YPG
Q
A
P
Q
I
V
E
N
Q
VT
Y
PLT
TT
M
LS
V
P
G
AK
T
VRG
F
S
QF-
G
DSY
VYV
I
FE
D
GT
D
P
Y
W
A
RS
R
V
L
EY
L
N
Q
V
QGK
LP
A-----
GV
SAELGPDAT
GVG
W
I
YEY
A
LV
D
RSGKHDLA
D
L
R
S
L
Q
DWF
L
KYE
L
K
TIP
D
V
A
E
V
ASV
G
GVVKEY
QV
V
I
DP
QR
L
A
QYG
I
SLAE
V
KS
A
L
DAS
N
QEAGG
SSI
--
-
-
--ELAEAEYM
V
R
A
SGY
LQT
L
D
D
F
NH
I
V
L
KASE
N
G
VP
V
Y
L
R
DVA
K
V
Q
I
G
P
E
MRRGI
A
EL
NG
E
G
E
V
A
G
GV
V
I
L
RS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSS
L
P
E
GV
E
IVTT
YD
RS
QL
I
DR
A
I
D
N
LSGK
L
L
E
EF
I
V
V
A
V
V
C
A
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
I
V
M
H
F
Q
G
L
N
A
N
I
MSL
G
G
I
A
I
A
V
G
A
M
VD
A
AIV
MI
EN
AH
K
R
L
E
E
WQHQHPDATL
D
NKT
R
WQ
V
IT
D
ASV
EVG
P
AL
FISLLI
I
T
LS
FIP
I
F
T
LE
G
QE
G
R
LFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------L
N
RF
L
IRV---
----
Y
HPLLL
KVL
HWPKTT
L
L
V
A
A
L
SVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TD
K
--
LIMSVPE
V
A
R
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMD
K
II
E
EL
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LST
G
IK
S
PIGIK
V
SGTVLADI
D
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
LE
GGRYIN
V
E
IN
RE
KA
A
R
Y
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DS
P
QA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DIKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YI
D
A
RDRD
M
V
S
V
V
HDLQKAIAEK
V
Q
LK
P
G
TSVA
F
S
G
--
-Q
FE
LL
E
RANHKLK
L
M
VP
M
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAI
E
AV
PSLNNPQTFSE
QKLD
EA
LYH
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
GAGS
E
VMSR
I
A
A
PM
I
GGM
IT
A
P
LL
S
L
F
II
P
AA
Y
K
L
M
WLHRHRVRK
fig|316407.3.peg.556
Escherichia coli W3110
MIEWIIRR
S
VA
NRF
L
VLMG
A
L
F
L
S
I
W
G
TWT
I
IN
T
PV
D
AL
P
D
L
SD
V
Q
V
I
I
K
T
S
YPG
Q
A
P
Q
I
V
E
N
Q
VT
Y
PLT
TT
M
LS
V
P
G
AK
T
VRG
F
S
QF-
G
DSY
VYV
I
FE
D
GT
D
P
Y
W
A
RS
R
V
L
EY
L
N
Q
V
QGK
LP
A-----
GV
SAELGPDAT
GVG
W
I
YEY
A
LV
D
RSGKHDLA
D
L
R
S
L
Q
DWF
L
KYE
L
K
TIP
D
V
A
E
V
ASV
G
GVVKEY
QV
V
I
DP
QR
L
A
QYG
I
SLAE
V
KS
A
L
DAS
N
QEAGG
SSI
--
-
-
--ELAEAEYM
V
R
A
SGY
LQT
L
D
D
F
NH
I
V
L
KASE
N
G
VP
V
Y
L
R
DVA
K
V
Q
I
G
P
E
MRRGI
A
EL
NG
E
G
E
V
A
G
GV
V
I
L
RS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSS
L
P
E
GV
E
IVTT
YD
RS
QL
I
DR
A
I
D
N
LSGK
L
L
E
EF
I
V
V
A
V
V
C
A
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
I
V
M
H
F
Q
G
L
N
A
N
I
MSL
G
G
I
A
I
A
V
G
A
M
VD
A
AIV
MI
EN
AH
K
R
L
E
E
WQHQHPDATL
D
NKT
R
WQ
V
IT
D
ASV
EVG
P
AL
FISLLI
I
T
LS
FIP
I
F
T
LE
G
QE
G
R
LFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------L
N
RF
L
IRV---
----
Y
HPLLL
KVL
HWPKTT
L
L
V
A
A
L
SVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TD
K
--
LIMSVPE
V
A
R
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMD
K
II
E
EL
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LST
G
IK
S
PIGIK
V
SGTVLADI
D
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
LE
GGRYIN
V
E
IN
RE
KA
A
R
Y
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DS
P
QA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DIKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YI
D
A
RDRD
M
V
S
V
V
HDLQKAIAEK
V
Q
LK
P
G
TSVA
F
S
G
--
-Q
FE
LL
E
RANHKLK
L
M
VP
M
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAI
E
AV
PSLNNPQTFSE
QKLD
EA
LYH
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
GAGS
E
VMSR
I
A
A
PM
I
GGM
IT
A
P
LL
S
L
F
II
P
AA
Y
K
L
M
WLHRHRVRK
fig|316385.5.peg.527
Escherichia coli str. K-12 substr. DH10B
MIEWIIRR
S
VA
NRF
L
VLMG
A
L
F
L
S
I
W
G
TWT
I
IN
T
PV
D
AL
P
D
L
SD
V
Q
V
I
I
K
T
S
YPG
Q
A
P
Q
I
V
E
N
Q
VT
Y
PLT
TT
M
LS
V
P
G
AK
T
VRG
F
S
QF-
G
DSY
VYV
I
FE
D
GT
D
P
Y
W
A
RS
R
V
L
EY
L
N
Q
V
QGK
LP
A-----
GV
SAELGPDAT
GVG
W
I
YEY
A
LV
D
RSGKHDLA
D
L
R
S
L
Q
DWF
L
KYE
L
K
TIP
D
V
A
E
V
ASV
G
GVVKEY
QV
V
I
DP
QR
L
A
QYG
I
SLAE
V
KS
A
L
DAS
N
QEAGG
SSI
--
-
-
--ELAEAEYM
V
R
A
SGY
LQT
L
D
D
F
NH
I
V
L
KASE
N
G
VP
V
Y
L
R
DVA
K
V
Q
I
G
P
E
MRRGI
A
EL
NG
E
G
E
V
A
G
GV
V
I
L
RS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSS
L
P
E
GV
E
IVTT
YD
RS
QL
I
DR
A
I
D
N
LSGK
L
L
E
EF
I
V
V
A
V
V
C
A
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
I
V
M
H
F
Q
G
L
N
A
N
I
MSL
G
G
I
A
I
A
V
G
A
M
VD
A
AIV
MI
EN
AH
K
R
L
E
E
WQHQHPDATL
D
NKT
R
WQ
V
IT
D
ASV
EVG
P
AL
FISLLI
I
T
LS
FIP
I
F
T
LE
G
QE
G
R
LFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------L
N
RF
L
IRV---
----
Y
HPLLL
KVL
HWPKTT
L
L
V
A
A
L
SVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TD
K
--
LIMSVPE
V
A
R
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMD
K
II
E
EL
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LST
G
IK
S
PIGIK
V
SGTVLADI
D
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
LE
GGRYIN
V
E
IN
RE
KA
A
R
Y
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DS
P
QA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DIKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YI
D
A
RDRD
M
V
S
V
V
HDLQKAIAEK
V
Q
LK
P
G
TSVA
F
S
G
--
-Q
FE
LL
E
RANHKLK
L
M
VP
M
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAI
E
AV
PSLNNPQTFSE
QKLD
EA
LYH
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
GAGS
E
VMSR
I
A
A
PM
I
GGM
IT
A
P
LL
S
L
F
II
P
AA
Y
K
L
M
WLHRHRVRK
fig|316385.5.peg.638
Escherichia coli str. K-12 substr. DH10B
MIEWIIRR
S
VA
NRF
L
VLMG
A
L
F
L
S
I
W
G
TWT
I
IN
T
PV
D
AL
P
D
L
SD
V
Q
V
I
I
K
T
S
YPG
Q
A
P
Q
I
V
E
N
Q
VT
Y
PLT
TT
M
LS
V
P
G
AK
T
VRG
F
S
QF-
G
DSY
VYV
I
FE
D
GT
D
P
Y
W
A
RS
R
V
L
EY
L
N
Q
V
QGK
LP
A-----
GV
SAELGPDAT
GVG
W
I
YEY
A
LV
D
RSGKHDLA
D
L
R
S
L
Q
DWF
L
KYE
L
K
TIP
D
V
A
E
V
ASV
G
GVVKEY
QV
V
I
DP
QR
L
A
QYG
I
SLAE
V
KS
A
L
DAS
N
QEAGG
SSI
--
-
-
--ELAEAEYM
V
R
A
SGY
LQT
L
D
D
F
NH
I
V
L
KASE
N
G
VP
V
Y
L
R
DVA
K
V
Q
I
G
P
E
MRRGI
A
EL
NG
E
G
E
V
A
G
GV
V
I
L
RS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSS
L
P
E
GV
E
IVTT
YD
RS
QL
I
DR
A
I
D
N
LSGK
L
L
E
EF
I
V
V
A
V
V
C
A
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
I
V
M
H
F
Q
G
L
N
A
N
I
MSL
G
G
I
A
I
A
V
G
A
M
VD
A
AIV
MI
EN
AH
K
R
L
E
E
WQHQHPDATL
D
NKT
R
WQ
V
IT
D
ASV
EVG
P
AL
FISLLI
I
T
LS
FIP
I
F
T
LE
G
QE
G
R
LFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------L
N
RF
L
IRV---
----
Y
HPLLL
KVL
HWPKTT
L
L
V
A
A
L
SVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TD
K
--
LIMSVPE
V
A
R
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMD
K
II
E
EL
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LST
G
IK
S
PIGIK
V
SGTVLADI
D
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
LE
GGRYIN
V
E
IN
RE
KA
A
R
Y
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DS
P
QA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DIKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YI
D
A
RDRD
M
V
S
V
V
HDLQKAIAEK
V
Q
LK
P
G
TSVA
F
S
G
--
-Q
FE
LL
E
RANHKLK
L
M
VP
M
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAI
E
AV
PSLNNPQTFSE
QKLD
EA
LYH
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
GAGS
E
VMSR
I
A
A
PM
I
GGM
IT
A
P
LL
S
L
F
II
P
AA
Y
K
L
M
WLHRHRVRK
fig|316385.7.peg.535
Escherichia coli str. K-12 substr. DH10B
MIEWIIRR
S
VA
NRF
L
VLMG
A
L
F
L
S
I
W
G
TWT
I
IN
T
PV
D
AL
P
D
L
SD
V
Q
V
I
I
K
T
S
YPG
Q
A
P
Q
I
V
E
N
Q
VT
Y
PLT
TT
M
LS
V
P
G
AK
T
VRG
F
S
QF-
G
DSY
VYV
I
FE
D
GT
D
P
Y
W
A
RS
R
V
L
EY
L
N
Q
V
QGK
LP
A-----
GV
SAELGPDAT
GVG
W
I
YEY
A
LV
D
RSGKHDLA
D
L
R
S
L
Q
DWF
L
KYE
L
K
TIP
D
V
A
E
V
ASV
G
GVVKEY
QV
V
I
DP
QR
L
A
QYG
I
SLAE
V
KS
A
L
DAS
N
QEAGG
SSI
--
-
-
--ELAEAEYM
V
R
A
SGY
LQT
L
D
D
F
NH
I
V
L
KASE
N
G
VP
V
Y
L
R
DVA
K
V
Q
I
G
P
E
MRRGI
A
EL
NG
E
G
E
V
A
G
GV
V
I
L
RS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSS
L
P
E
GV
E
IVTT
YD
RS
QL
I
DR
A
I
D
N
LSGK
L
L
E
EF
I
V
V
A
V
V
C
A
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
I
V
M
H
F
Q
G
L
N
A
N
I
MSL
G
G
I
A
I
A
V
G
A
M
VD
A
AIV
MI
EN
AH
K
R
L
E
E
WQHQHPDATL
D
NKT
R
WQ
V
IT
D
ASV
EVG
P
AL
FISLLI
I
T
LS
FIP
I
F
T
LE
G
QE
G
R
LFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------L
N
RF
L
IRV---
----
Y
HPLLL
KVL
HWPKTT
L
L
V
A
A
L
SVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TD
K
--
LIMSVPE
V
A
R
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMD
K
II
E
EL
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LST
G
IK
S
PIGIK
V
SGTVLADI
D
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
LE
GGRYIN
V
E
IN
RE
KA
A
R
Y
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DS
P
QA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DIKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YI
D
A
RDRD
M
V
S
V
V
HDLQKAIAEK
V
Q
LK
P
G
TSVA
F
S
G
--
-Q
FE
LL
E
RANHKLK
L
M
VP
M
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAI
E
AV
PSLNNPQTFSE
QKLD
EA
LYH
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
GAGS
E
VMSR
I
A
A
PM
I
GGM
IT
A
P
LL
S
L
F
II
P
AA
Y
K
L
M
WLHRHRVRK
fig|316385.7.peg.646
Escherichia coli str. K-12 substr. DH10B
MIEWIIRR
S
VA
NRF
L
VLMG
A
L
F
L
S
I
W
G
TWT
I
IN
T
PV
D
AL
P
D
L
SD
V
Q
V
I
I
K
T
S
YPG
Q
A
P
Q
I
V
E
N
Q
VT
Y
PLT
TT
M
LS
V
P
G
AK
T
VRG
F
S
QF-
G
DSY
VYV
I
FE
D
GT
D
P
Y
W
A
RS
R
V
L
EY
L
N
Q
V
QGK
LP
A-----
GV
SAELGPDAT
GVG
W
I
YEY
A
LV
D
RSGKHDLA
D
L
R
S
L
Q
DWF
L
KYE
L
K
TIP
D
V
A
E
V
ASV
G
GVVKEY
QV
V
I
DP
QR
L
A
QYG
I
SLAE
V
KS
A
L
DAS
N
QEAGG
SSI
--
-
-
--ELAEAEYM
V
R
A
SGY
LQT
L
D
D
F
NH
I
V
L
KASE
N
G
VP
V
Y
L
R
DVA
K
V
Q
I
G
P
E
MRRGI
A
EL
NG
E
G
E
V
A
G
GV
V
I
L
RS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSS
L
P
E
GV
E
IVTT
YD
RS
QL
I
DR
A
I
D
N
LSGK
L
L
E
EF
I
V
V
A
V
V
C
A
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
I
V
M
H
F
Q
G
L
N
A
N
I
MSL
G
G
I
A
I
A
V
G
A
M
VD
A
AIV
MI
EN
AH
K
R
L
E
E
WQHQHPDATL
D
NKT
R
WQ
V
IT
D
ASV
EVG
P
AL
FISLLI
I
T
LS
FIP
I
F
T
LE
G
QE
G
R
LFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------L
N
RF
L
IRV---
----
Y
HPLLL
KVL
HWPKTT
L
L
V
A
A
L
SVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TD
K
--
LIMSVPE
V
A
R
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMD
K
II
E
EL
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LST
G
IK
S
PIGIK
V
SGTVLADI
D
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
LE
GGRYIN
V
E
IN
RE
KA
A
R
Y
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DS
P
QA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DIKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YI
D
A
RDRD
M
V
S
V
V
HDLQKAIAEK
V
Q
LK
P
G
TSVA
F
S
G
--
-Q
FE
LL
E
RANHKLK
L
M
VP
M
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAI
E
AV
PSLNNPQTFSE
QKLD
EA
LYH
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
GAGS
E
VMSR
I
A
A
PM
I
GGM
IT
A
P
LL
S
L
F
II
P
AA
Y
K
L
M
WLHRHRVRK
fig|511145.12.peg.599
Escherichia coli str. K-12 substr. MG1655
MIEWIIRR
S
VA
NRF
L
VLMG
A
L
F
L
S
I
W
G
TWT
I
IN
T
PV
D
AL
P
D
L
SD
V
Q
V
I
I
K
T
S
YPG
Q
A
P
Q
I
V
E
N
Q
VT
Y
PLT
TT
M
LS
V
P
G
AK
T
VRG
F
S
QF-
G
DSY
VYV
I
FE
D
GT
D
P
Y
W
A
RS
R
V
L
EY
L
N
Q
V
QGK
LP
A-----
GV
SAELGPDAT
GVG
W
I
YEY
A
LV
D
RSGKHDLA
D
L
R
S
L
Q
DWF
L
KYE
L
K
TIP
D
V
A
E
V
ASV
G
GVVKEY
QV
V
I
DP
QR
L
A
QYG
I
SLAE
V
KS
A
L
DAS
N
QEAGG
SSI
--
-
-
--ELAEAEYM
V
R
A
SGY
LQT
L
D
D
F
NH
I
V
L
KASE
N
G
VP
V
Y
L
R
DVA
K
V
Q
I
G
P
E
MRRGI
A
EL
NG
E
G
E
V
A
G
GV
V
I
L
RS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSS
L
P
E
GV
E
IVTT
YD
RS
QL
I
DR
A
I
D
N
LSGK
L
L
E
EF
I
V
V
A
V
V
C
A
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
I
V
M
H
F
Q
G
L
N
A
N
I
MSL
G
G
I
A
I
A
V
G
A
M
VD
A
AIV
MI
EN
AH
K
R
L
E
E
WQHQHPDATL
D
NKT
R
WQ
V
IT
D
ASV
EVG
P
AL
FISLLI
I
T
LS
FIP
I
F
T
LE
G
QE
G
R
LFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------L
N
RF
L
IRV---
----
Y
HPLLL
KVL
HWPKTT
L
L
V
A
A
L
SVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TD
K
--
LIMSVPE
V
A
R
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMD
K
II
E
EL
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LST
G
IK
S
PIGIK
V
SGTVLADI
D
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
LE
GGRYIN
V
E
IN
RE
KA
A
R
Y
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DS
P
QA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DIKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YI
D
A
RDRD
M
V
S
V
V
HDLQKAIAEK
V
Q
LK
P
G
TSVA
F
S
G
--
-Q
FE
LL
E
RANHKLK
L
M
VP
M
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAI
E
AV
PSLNNPQTFSE
QKLD
EA
LYH
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
GAGS
E
VMSR
I
A
A
PM
I
GGM
IT
A
P
LL
S
L
F
II
P
AA
Y
K
L
M
WLHRHRVRK
fig|511145.6.peg.590
Escherichia coli str. K-12 substr. MG1655
MIEWIIRR
S
VA
NRF
L
VLMG
A
L
F
L
S
I
W
G
TWT
I
IN
T
PV
D
AL
P
D
L
SD
V
Q
V
I
I
K
T
S
YPG
Q
A
P
Q
I
V
E
N
Q
VT
Y
PLT
TT
M
LS
V
P
G
AK
T
VRG
F
S
QF-
G
DSY
VYV
I
FE
D
GT
D
P
Y
W
A
RS
R
V
L
EY
L
N
Q
V
QGK
LP
A-----
GV
SAELGPDAT
GVG
W
I
YEY
A
LV
D
RSGKHDLA
D
L
R
S
L
Q
DWF
L
KYE
L
K
TIP
D
V
A
E
V
ASV
G
GVVKEY
QV
V
I
DP
QR
L
A
QYG
I
SLAE
V
KS
A
L
DAS
N
QEAGG
SSI
--
-
-
--ELAEAEYM
V
R
A
SGY
LQT
L
D
D
F
NH
I
V
L
KASE
N
G
VP
V
Y
L
R
DVA
K
V
Q
I
G
P
E
MRRGI
A
EL
NG
E
G
E
V
A
G
GV
V
I
L
RS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSS
L
P
E
GV
E
IVTT
YD
RS
QL
I
DR
A
I
D
N
LSGK
L
L
E
EF
I
V
V
A
V
V
C
A
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
I
V
M
H
F
Q
G
L
N
A
N
I
MSL
G
G
I
A
I
A
V
G
A
M
VD
A
AIV
MI
EN
AH
K
R
L
E
E
WQHQHPDATL
D
NKT
R
WQ
V
IT
D
ASV
EVG
P
AL
FISLLI
I
T
LS
FIP
I
F
T
LE
G
QE
G
R
LFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------L
N
RF
L
IRV---
----
Y
HPLLL
KVL
HWPKTT
L
L
V
A
A
L
SVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TD
K
--
LIMSVPE
V
A
R
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMD
K
II
E
EL
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LST
G
IK
S
PIGIK
V
SGTVLADI
D
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
LE
GGRYIN
V
E
IN
RE
KA
A
R
Y
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DS
P
QA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DIKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YI
D
A
RDRD
M
V
S
V
V
HDLQKAIAEK
V
Q
LK
P
G
TSVA
F
S
G
--
-Q
FE
LL
E
RANHKLK
L
M
VP
M
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAI
E
AV
PSLNNPQTFSE
QKLD
EA
LYH
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
GAGS
E
VMSR
I
A
A
PM
I
GGM
IT
A
P
LL
S
L
F
II
P
AA
Y
K
L
M
WLHRHRVRK
fig|573235.3.peg.654
Escherichia coli O26:H11 str. 11368
MIEWIIRR
S
VA
NRF
L
VLMG
A
L
F
L
S
I
W
G
TWT
I
IN
T
PV
D
AL
P
D
L
SD
V
Q
V
I
I
K
T
S
YPG
Q
A
P
Q
I
V
E
N
Q
VT
Y
PLT
TT
M
LS
V
P
G
AK
T
VRG
F
S
QF-
G
DSY
VYV
I
FE
D
GT
D
P
Y
W
A
RS
R
V
L
EY
L
N
Q
V
QGK
LP
A-----
GV
SAELGPDAT
GVG
W
I
YEY
A
LV
D
RSGKHDLA
D
L
R
S
L
Q
DWF
L
KYE
L
K
TIP
D
V
A
E
V
ASV
G
GVVKEY
QV
V
I
DP
QR
L
A
QYG
I
SLAE
V
KS
A
L
DAS
N
QEAGG
SSI
--
-
-
--ELAEAEYM
V
R
A
SGY
LQT
L
D
D
F
NH
I
V
L
KASE
N
G
VP
V
Y
L
R
DVA
K
V
L
I
G
P
E
MRRGI
A
EL
NG
E
G
E
V
A
G
GV
V
I
L
RS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSS
L
P
E
GV
E
IVTT
YD
RS
QL
I
DR
A
I
D
N
LSGK
L
L
E
EF
I
V
V
A
V
V
C
A
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
I
V
M
H
F
Q
G
L
N
A
N
I
MSL
G
G
I
A
I
A
V
G
A
M
VD
A
AIV
MI
EN
AH
K
R
L
E
E
WQHQHPDATL
D
NKT
R
WQ
V
IT
D
ASV
EVG
P
AL
FISLLI
I
T
LS
FIP
I
F
T
LE
G
QE
G
R
LFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------L
N
RF
L
IRV---
----
Y
HPLLL
KVL
HWPKTT
L
L
V
A
A
L
SVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TD
K
--
LIMSVPE
V
A
R
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMD
K
II
E
EL
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LST
G
IK
S
PIGIK
V
SGTVLADI
D
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
LE
GGRYIN
V
E
IN
RE
KA
A
R
Y
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DS
P
QA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DIKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YI
D
A
RDRD
M
V
S
V
V
HDLQKAIAEK
V
Q
LK
P
G
TSVA
F
S
G
--
-Q
FE
LL
E
RANHKLK
L
M
VP
M
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAI
E
AE
PSLNNPQTFSE
QKLD
EA
LYH
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
GAGS
E
VMSR
I
A
A
PM
I
GGM
IT
A
P
LL
S
L
F
II
P
AA
Y
K
L
M
WLHRHRVRK
fig|749540.3.peg.485
Escherichia coli MS 146-1
MIEWIIRR
S
VA
NRF
L
VLMG
A
L
F
L
S
I
W
G
TWT
I
IN
T
PV
D
AL
P
D
L
SD
V
Q
V
S
I
K
T
S
YPG
Q
A
P
Q
I
V
E
N
Q
VT
Y
PLT
TT
M
LS
V
P
G
AK
T
VRG
F
S
QF-
G
DSY
VYV
I
FE
D
GT
D
P
Y
W
A
RS
R
V
L
EY
L
N
Q
V
QGK
LP
A-----
GV
SAELGPDAT
GVG
W
I
YEY
A
LV
D
RSGKHDLA
D
L
R
S
L
Q
DWF
L
KYE
L
K
TIP
D
V
A
E
V
ASV
G
GVVKEY
QV
V
I
DP
QR
L
A
QYG
I
SLAE
V
KS
A
L
DAS
N
QEAGG
SSI
--
-
-
--ELAEAEYM
V
R
A
SGY
LQT
L
D
D
F
NH
I
V
L
KASE
N
G
VP
V
Y
L
R
DVA
K
V
Q
I
G
P
E
MRRGI
A
EL
NG
E
G
E
V
A
G
GV
V
I
L
RS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSS
L
P
E
GV
E
IVTT
YD
RS
QL
I
DR
A
I
D
N
LSGK
L
L
E
EF
I
V
V
A
V
V
C
A
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
I
V
M
H
F
Q
G
L
N
A
N
I
MSL
G
G
I
A
I
A
V
G
A
M
VD
A
AIV
MI
EN
AH
K
R
L
E
E
WQHQHPDATL
D
NKT
R
WQ
V
IT
D
ASV
EVG
P
AL
FISLLI
I
T
LS
FIP
I
F
T
LE
G
QE
G
R
LFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------L
N
RF
L
IRV---
----
Y
HPLLL
KVL
HWPKTT
L
L
V
A
A
L
SVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TD
K
--
LIMSVPE
V
A
R
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMD
K
II
E
EL
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LST
G
IK
S
PIGIK
V
SGTVLADI
D
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
LE
GGRYIN
V
E
IN
RE
KA
A
R
Y
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DS
P
QA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YI
D
A
RDRD
M
V
S
V
V
HDLQKAIAEK
V
Q
LK
P
G
TSVA
F
S
G
--
-Q
FE
LL
E
RANHKLK
L
M
VP
M
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAI
E
AE
PSLNNPQTFSE
QKLD
EA
LYH
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
GAGS
E
VMSR
I
A
A
PM
I
GGM
IT
A
P
LL
S
L
F
II
P
AA
Y
K
L
M
WLHRHRVRK
fig|749537.3.peg.4060
Escherichia coli MS 115-1
MIEWIIRR
S
VA
NRF
L
VLMG
A
L
F
L
S
I
W
G
TWT
I
IN
T
PV
D
AL
P
D
L
SD
V
Q
V
I
I
K
T
S
YPG
Q
A
P
Q
I
V
E
N
Q
VT
Y
PLT
TT
M
LS
V
P
G
AK
T
VRG
F
S
QF-
G
DSY
VYV
I
FE
D
GT
D
P
Y
W
A
RS
R
V
L
EY
L
N
Q
V
QGK
LP
A-----
GV
SAELGPDAT
GVG
W
I
YEY
A
LV
D
RSGKHDLA
D
L
R
S
L
Q
DWF
L
KYE
L
K
TIP
D
V
A
E
V
ASV
G
GVVKEY
QV
V
I
DP
QR
L
A
QYG
I
SLGE
V
KN
A
L
DAS
N
QEAGG
SSI
--
-
-
--ELAEAEYM
V
R
A
SGY
LQT
L
D
D
F
NH
I
V
L
KASE
N
G
VP
V
Y
L
R
DVA
K
V
Q
V
G
P
E
MRRGI
A
EL
NG
E
G
E
V
A
G
GV
V
I
L
RS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSS
L
P
E
GV
E
IVTT
YD
RS
QL
I
DR
A
I
D
N
LSGK
L
L
E
EF
I
V
V
A
V
V
C
A
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
I
V
M
H
F
Q
G
L
N
A
N
I
MSL
G
G
I
A
I
A
V
G
A
M
VD
A
AIV
MI
EN
AH
K
R
L
E
E
WQHQHPDATL
D
NKT
R
WQ
V
IT
D
ASV
EVG
P
AL
FISLLI
I
T
LS
FIP
I
F
T
LE
G
QE
G
R
LFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------L
N
RF
L
IRV---
----
Y
HPLLL
KVL
HWPKTT
L
L
V
A
A
L
SVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TD
K
--
LIMSVPE
V
A
R
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMD
K
II
E
EL
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LST
G
IK
S
PIGIK
V
SGTVLADI
D
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
LE
GGRYIN
V
E
IN
RE
KA
A
R
Y
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DS
P
QA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DIKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YI
D
A
RDRD
M
V
S
V
V
HDLQKAIAEK
V
Q
LK
P
G
TSVA
F
S
G
--
-Q
FE
LL
E
RANHKLK
L
M
VP
M
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAI
E
AE
PSLNNPQTFSE
QKLD
EA
LYH
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
GAGS
E
VMSR
I
A
A
PM
I
GGM
IT
A
P
LL
S
L
F
II
P
AA
Y
K
L
M
WLHRHRVRK
fig|656408.3.peg.504
Escherichia coli H591
MIEWIIRR
S
VA
NRF
L
VLMG
A
L
F
L
S
I
W
G
TWT
I
IN
T
PV
D
AL
P
D
L
SD
V
Q
V
I
I
K
T
S
YPG
Q
A
P
Q
I
V
E
N
Q
VT
Y
PLT
TT
M
LS
V
P
G
AK
T
VRG
F
S
QF-
G
DSY
VYV
I
FE
D
GT
D
P
Y
W
A
RS
R
V
L
EY
L
N
Q
V
QGK
LP
A-----
GV
SAELGPDAT
GVG
W
I
YEY
A
LV
D
RSGKHDLA
D
L
R
S
L
Q
DWF
L
KYE
L
K
TIP
D
V
A
E
V
ASV
G
GVVKEY
QV
V
I
DP
QR
L
A
QYG
I
SLAE
V
KS
A
L
DAS
N
QEAGG
SSI
--
-
-
--ELAEAEYM
V
R
A
SGY
LQT
L
D
D
F
NH
I
V
L
KASE
N
G
VP
V
Y
L
R
DVA
K
V
Q
I
G
P
E
MRRGI
A
EL
NG
E
G
E
V
A
G
GV
V
I
L
RS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSS
L
P
E
GV
E
IVTT
YD
RS
QL
I
DR
A
I
D
N
LSGK
L
L
E
EF
I
V
V
A
V
V
C
A
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
I
V
M
H
F
Q
G
L
N
A
N
I
MSL
G
G
I
A
I
A
V
G
A
M
VD
A
AIV
MI
EN
AH
K
R
L
E
E
WQHQHPDATL
D
NKT
R
WQ
V
IT
D
ASV
EVG
P
AL
FISLLI
I
T
LS
FIP
I
F
T
LE
G
QE
G
R
LFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------L
N
RF
L
IRV---
----
Y
HPLLL
KVL
HWPKTT
L
L
V
T
A
L
SVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TD
K
--
LIMSVPE
V
A
R
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QD
QW
R
PG--MTMD
K
II
E
EL
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LST
G
IK
S
PIGIK
V
SGTVLADI
D
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
LE
GGRYIN
V
E
IN
RE
KA
A
R
Y
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DS
P
QA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YI
D
A
RDRD
M
V
S
V
V
HDLQKAIAEK
V
Q
LK
P
G
TSVA
F
S
G
--
-Q
FE
LL
E
RANHKLK
L
M
VP
M
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAI
E
AE
PSLNNPQTFSE
QKLD
EA
LYH
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
GAGS
E
VMSR
I
A
A
PM
I
GGM
IT
A
P
LL
S
L
F
II
P
AA
Y
K
L
M
WLHRHRVRK
fig|679206.4.peg.4715
Escherichia coli MS 119-7
MIEWIIRR
S
VA
NRF
L
VLMG
A
L
F
L
S
I
W
G
TWT
I
IN
T
PV
D
AL
P
D
L
SD
V
Q
V
I
I
K
T
S
YPG
Q
A
P
Q
I
V
E
N
Q
VT
Y
PLT
TT
M
LS
V
P
G
AK
T
VRG
F
S
QF-
G
DSY
VYV
I
FE
D
GT
D
P
Y
W
A
RS
R
V
L
EY
L
N
Q
V
QGK
LP
A-----
GV
SAELGPDAT
GVG
W
I
YEY
A
LV
D
RSGKHDLA
D
L
R
S
L
Q
DWF
L
KYE
L
K
TIP
D
V
A
E
V
ASV
G
GVVKEY
QV
V
I
DP
QR
L
A
QYG
I
SLAE
V
KS
A
L
DAS
N
QEAGG
SSI
--
-
-
--ELAEAEYM
V
R
A
SGY
LQT
L
D
D
F
NH
I
V
L
KASE
N
G
VP
V
Y
L
R
DVA
K
V
Q
I
G
P
E
MRRGI
A
EL
NG
E
G
E
V
A
G
GV
V
I
L
RS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSS
L
P
E
GV
E
IVTT
YD
RS
QL
I
DR
A
I
D
N
LSGK
L
L
E
EF
I
V
V
A
V
V
C
A
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
I
V
M
H
F
Q
G
L
N
A
N
I
MSL
G
G
I
A
I
A
V
G
A
M
VD
A
AIV
MI
EN
AH
K
R
L
E
E
WQHQHPDATL
D
NKT
R
WQ
V
IT
D
ASV
EVG
P
AL
FISLLI
I
T
LS
FIP
I
F
T
LE
G
QE
G
R
LFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------L
N
RF
L
IRV---
----
Y
HPLLL
KVL
HWPKTT
L
L
V
T
A
L
SVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TD
K
--
LIMSVPE
V
A
R
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QD
QW
R
PG--MTMD
K
II
E
EL
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LST
G
IK
S
PIGIK
V
SGTVLADI
D
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
LE
GGRYIN
V
E
IN
RE
KA
A
R
Y
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DS
P
QA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YI
D
A
RDRD
M
V
S
V
V
HDLQKAIAEK
V
Q
LK
P
G
TSVA
F
S
G
--
-Q
FE
LL
E
RANHKLK
L
M
VP
M
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAI
E
AE
PSLNNPQTFSE
QKLD
EA
LYH
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
GAGS
E
VMSR
I
A
A
PM
I
GGM
IT
A
P
LL
S
L
F
II
P
AA
Y
K
L
M
WLHRHRVRK
fig|656444.3.peg.1047
Escherichia coli TA280
MIEWIIRR
S
VA
NRF
L
VLMG
A
L
F
L
S
I
W
G
TWT
I
IN
T
PV
D
AL
P
D
L
SD
V
Q
V
I
I
K
T
S
YPG
Q
A
P
Q
I
V
E
N
Q
VT
Y
PLT
TT
M
LS
V
P
G
AK
T
VRG
F
S
QF-
G
DSY
VYV
I
FE
D
GT
D
P
Y
W
A
RS
R
V
L
EY
L
N
Q
V
QGK
LP
A-----
GV
SAELGPDAT
GVG
W
I
YEY
A
LV
D
RSGKHDLA
D
L
R
S
L
Q
DWF
L
KYE
L
K
TIP
D
V
A
E
V
ASV
G
GVVKEY
QV
V
I
DP
QR
L
A
QYG
I
SLAE
V
KS
A
L
DAS
N
QEAGG
SSI
--
-
-
--ELAEAEYM
V
R
A
SGY
LQT
L
D
D
F
NH
I
V
L
KASE
N
G
VP
V
Y
L
R
DVA
K
V
Q
I
G
P
E
MRRGI
A
EL
NG
E
G
E
V
A
G
GV
V
I
L
RS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSS
L
P
E
GV
E
IVTT
YD
RS
QL
I
DR
A
I
D
N
LSGK
L
L
E
EF
I
V
V
A
V
V
C
A
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
I
V
M
H
F
Q
G
L
N
A
N
I
MSL
G
G
I
A
I
A
V
G
A
M
VD
A
AIV
MI
EN
AH
K
R
L
E
E
WQHQHPDATL
D
NKT
R
WQ
V
IT
D
ASV
EVG
P
AL
FISLLI
I
T
LS
FIP
I
F
T
LE
G
QE
G
R
LFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------L
N
RF
L
IRV---
----
Y
HPLLL
KVL
HWPKTT
L
L
V
A
A
L
SVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TN
K
--
LIMSVPE
V
A
R
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QD
QW
R
PG--MTMD
K
II
E
EL
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LST
G
IK
S
PIGIK
V
SGTVLADI
D
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
LE
GGRYIN
V
E
IN
RE
KA
A
R
Y
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DS
P
QA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YI
D
A
RDRD
M
V
S
V
V
HDLQKAIAEK
V
Q
LK
P
G
TSVA
F
S
G
--
-Q
FE
LL
E
RANHKLK
L
M
VP
M
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAI
E
AE
PSLNNPQTFSE
QKLD
EA
LYH
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
GAGS
E
VMSR
I
A
A
PM
I
GGM
IT
A
P
LL
S
L
F
II
P
AA
Y
K
L
M
WLHRHRVRK
fig|585396.4.peg.625
Escherichia coli O111:H- str. 11128
MIEWIIRR
S
VA
NRF
L
VLMG
A
L
F
L
S
I
W
G
TWT
I
IN
T
PV
D
AL
P
D
L
SD
V
Q
V
I
I
K
T
S
YPG
Q
A
P
Q
I
V
E
N
Q
VT
Y
PLT
TT
M
LS
V
P
G
AK
T
VRG
F
S
QF-
G
DSY
VYV
I
FE
D
GT
D
P
Y
W
A
RS
R
V
L
EY
L
N
Q
V
QGK
LP
A-----
GV
SAELGPDAT
GVG
W
I
YEY
A
LV
D
RSGKHDLA
D
L
R
S
L
Q
DWF
L
KYE
L
K
TIP
D
V
A
E
V
ASV
G
GVVKEY
QV
V
I
DP
QR
L
A
QYG
I
SLAE
V
KS
A
L
DAS
N
QEAGG
SSI
--
-
-
--ELAEAEYM
V
R
A
SGY
LQT
L
D
D
F
NH
I
V
L
KASE
N
G
VP
V
Y
L
R
DVA
K
V
Q
I
G
P
E
MRRGI
A
EL
NG
E
G
E
V
A
G
GV
V
I
L
RS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSS
L
P
E
GV
E
IVTT
YD
RS
QL
I
DR
A
I
D
N
LSGK
L
L
E
EF
I
V
V
A
V
V
C
A
LFL
W
H
V
R
SA
L
VA
I
I
SL
L
L
G
L
C
IA
F
I
V
M
H
F
Q
G
L
N
A
N
I
MSL
G
G
I
A
I
A
V
G
A
M
VD
A
AIV
MI
EN
AH
K
R
L
E
E
WQHQHPDATL
D
NKT
R
WQ
V
IT
D
ASV
EVG
P
AL
FISLLI
I
T
LS
FIP
I
F
T
LE
G
QE
G
R
LFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------L
N
RF
L
IRV---
----
Y
HPLLL
KVL
HWPKTT
L
L
V
A
A
L
SVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TD
K
--
LIMSVPE
V
A
R
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMD
K
II
E
EL
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LST
G
IK
S
PIGIK
V
SGTVLADI
D
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
LE
GGRYIN
V
E
IN
RE
KA
A
R
Y
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DS
P
QA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DIKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YI
D
A
RDRD
M
V
S
V
V
HDLQKAIAEK
V
Q
LK
P
G
TSVA
F
S
G
--
-Q
FE
LL
E
RANHKLK
L
M
VP
M
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAI
E
AE
PSLNNPQTFSE
QKLD
EA
LYH
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
GAGS
E
VMSR
I
A
A
PM
I
GGM
IT
A
P
LL
S
L
F
II
P
AA
Y
K
L
M
WLHRHRVRK
fig|585397.7.peg.568
Escherichia coli ED1a
MIEWIIRR
S
VA
NRF
L
VLMG
A
L
F
L
S
I
W
G
TWT
I
IN
T
PV
D
AL
P
D
L
SD
V
Q
V
I
I
K
T
S
YPG
Q
A
P
Q
I
V
E
N
Q
VT
Y
PLT
TT
M
LS
V
P
G
AK
T
VRG
F
S
QF-
G
DSY
VYV
I
FE
D
GT
D
P
Y
W
A
RS
R
V
L
EY
L
N
Q
V
QGK
LP
A-----
GV
SAELGPDAT
GVG
W
I
YEY
A
LV
D
RSGKHDLA
D
L
R
S
L
Q
DWF
L
KYE
L
K
TIP
D
V
A
E
V
ASV
G
GVVKEY
QV
V
I
DP
QR
L
A
QYG
I
SLAE
V
KS
A
L
DAS
N
QEAGG
SSI
--
-
-
--ELAEAEYM
V
R
A
SGY
LQT
L
D
D
F
NH
I
V
L
KASE
N
G
VP
V
Y
L
R
DVA
K
V
Q
V
G
P
E
MRRGI
A
EL
NG
E
G
E
V
A
G
GV
V
I
L
RS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSS
L
P
E
GV
E
IVTT
YD
RS
QL
I
DR
A
I
D
N
LSGK
L
L
E
EF
I
V
V
A
V
V
C
A
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
I
V
M
H
F
Q
G
L
N
A
N
I
MSL
G
G
I
A
I
A
V
G
A
M
VD
A
AIV
MI
EN
AH
K
R
L
E
E
WQHQHPDATL
D
NKT
R
WQ
V
IT
D
ASV
EVG
P
AL
FISLLI
I
T
LS
FIP
I
F
T
LE
G
QE
G
R
LFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------L
N
RF
L
IRV---
----
Y
HPLLL
KVL
HWPKTT
L
L
V
A
A
L
SVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TD
K
--
LIMSVPE
V
A
R
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QD
QW
R
PG--MTMD
K
II
E
EL
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LST
G
IK
S
PIGIK
V
SGTVLADI
D
T
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
LE
GGRYIN
V
E
IN
RE
KA
A
R
Y
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DS
P
QA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YI
D
A
RDRD
M
V
S
V
V
HDLQKAIAEK
V
Q
LK
P
G
TSVA
F
S
G
--
-Q
FE
LL
E
RANHKLK
L
M
VP
M
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAI
E
AE
PSLNNPQTFSE
QKLD
EA
LYH
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
GAGS
E
VMSR
I
A
A
PM
I
GGM
IT
A
P
LL
S
L
F
II
P
AA
Y
K
L
M
WLHRHRVRK
fig|585397.9.peg.570
Escherichia coli ED1a
MIEWIIRR
S
VA
NRF
L
VLMG
A
L
F
L
S
I
W
G
TWT
I
IN
T
PV
D
AL
P
D
L
SD
V
Q
V
I
I
K
T
S
YPG
Q
A
P
Q
I
V
E
N
Q
VT
Y
PLT
TT
M
LS
V
P
G
AK
T
VRG
F
S
QF-
G
DSY
VYV
I
FE
D
GT
D
P
Y
W
A
RS
R
V
L
EY
L
N
Q
V
QGK
LP
A-----
GV
SAELGPDAT
GVG
W
I
YEY
A
LV
D
RSGKHDLA
D
L
R
S
L
Q
DWF
L
KYE
L
K
TIP
D
V
A
E
V
ASV
G
GVVKEY
QV
V
I
DP
QR
L
A
QYG
I
SLAE
V
KS
A
L
DAS
N
QEAGG
SSI
--
-
-
--ELAEAEYM
V
R
A
SGY
LQT
L
D
D
F
NH
I
V
L
KASE
N
G
VP
V
Y
L
R
DVA
K
V
Q
V
G
P
E
MRRGI
A
EL
NG
E
G
E
V
A
G
GV
V
I
L
RS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSS
L
P
E
GV
E
IVTT
YD
RS
QL
I
DR
A
I
D
N
LSGK
L
L
E
EF
I
V
V
A
V
V
C
A
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
I
V
M
H
F
Q
G
L
N
A
N
I
MSL
G
G
I
A
I
A
V
G
A
M
VD
A
AIV
MI
EN
AH
K
R
L
E
E
WQHQHPDATL
D
NKT
R
WQ
V
IT
D
ASV
EVG
P
AL
FISLLI
I
T
LS
FIP
I
F
T
LE
G
QE
G
R
LFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------L
N
RF
L
IRV---
----
Y
HPLLL
KVL
HWPKTT
L
L
V
A
A
L
SVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TD
K
--
LIMSVPE
V
A
R
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QD
QW
R
PG--MTMD
K
II
E
EL
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LST
G
IK
S
PIGIK
V
SGTVLADI
D
T
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
LE
GGRYIN
V
E
IN
RE
KA
A
R
Y
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DS
P
QA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YI
D
A
RDRD
M
V
S
V
V
HDLQKAIAEK
V
Q
LK
P
G
TSVA
F
S
G
--
-Q
FE
LL
E
RANHKLK
L
M
VP
M
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAI
E
AE
PSLNNPQTFSE
QKLD
EA
LYH
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
GAGS
E
VMSR
I
A
A
PM
I
GGM
IT
A
P
LL
S
L
F
II
P
AA
Y
K
L
M
WLHRHRVRK
fig|749546.3.peg.3398
Escherichia coli MS 185-1
MIEWIIRR
S
VA
NRF
L
VLMG
A
L
F
L
S
I
W
G
TWT
I
IN
T
PV
D
AL
P
D
L
SD
V
Q
V
I
I
K
T
S
YPG
Q
A
P
Q
I
V
E
N
Q
VT
Y
PLT
TT
M
LS
V
P
G
AK
T
VRG
F
S
QF-
G
DSY
VYV
I
FE
D
GT
D
P
Y
W
A
RS
R
V
L
EY
L
N
Q
V
QGK
LP
A-----
GV
SAELGPDAT
GVG
W
I
YEY
A
LV
D
RSGKHDLA
D
L
R
S
L
Q
DWF
L
KYE
L
K
TIP
D
V
A
E
V
ASV
G
GVVKEY
QV
V
I
DP
QR
L
A
QYG
I
SLAE
V
KS
A
L
DAS
N
QEAGG
SSI
--
-
-
--ELAEAEYM
V
R
A
SGY
LQT
L
D
D
F
NH
I
V
L
KASE
N
G
VP
V
Y
L
R
DVA
K
V
Q
V
G
P
E
MRRGI
A
EL
NG
E
G
E
V
A
G
GV
V
I
L
RS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSS
L
P
E
GV
E
IVTT
YD
RS
QL
I
DR
A
I
D
N
LSGK
L
L
E
EF
I
V
V
A
V
V
C
A
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
I
V
M
H
F
Q
G
L
N
A
N
I
MSL
G
G
I
A
I
A
V
G
A
M
VD
A
AIV
MI
EN
AH
K
R
L
E
E
WQHQHPDATL
D
NKT
R
WQ
V
IT
D
ASV
EVG
P
AL
FISLLI
I
T
LS
FIP
I
F
T
LE
G
QE
G
R
LFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------L
N
RF
L
IRV---
----
Y
HPLLL
KVL
HWPKTT
L
L
V
A
A
L
SVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TD
K
--
LIMSVPE
V
A
R
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QD
QW
R
PG--MTMD
K
II
E
EL
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LST
G
IK
S
PIGIK
V
SGTVLADI
D
T
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
LE
GGRYIN
V
E
IN
RE
KA
A
R
Y
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DS
P
QA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YI
D
A
RDRD
M
V
S
V
V
HDLQKAIAEK
V
Q
LK
P
G
TSVA
F
S
G
--
-Q
FE
LL
E
RANHKLK
L
M
VP
M
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAI
E
AE
PSLNNPQTFSE
QKLD
EA
LYH
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
GAGS
E
VMSR
I
A
A
PM
I
GGM
IT
A
P
LL
S
L
F
II
P
AA
Y
K
L
M
WLHRHRVRK
fig|749528.3.peg.4064
Escherichia coli MS 45-1
MIEWIIRR
S
VA
NRF
L
VLMG
A
L
F
L
S
I
W
G
TWT
I
IN
T
PV
D
AL
P
D
L
SD
V
Q
V
I
I
K
T
S
YPG
Q
A
P
Q
I
V
E
N
Q
VT
Y
PLT
TT
M
LS
V
P
G
AK
T
VRG
F
S
QF-
G
DSY
VYV
I
FE
D
GT
D
P
Y
W
A
RS
R
V
L
EY
L
N
Q
V
QGK
LP
A-----
GV
SAELGPDAT
GVG
W
I
YEY
A
LV
D
RSGKHDLA
D
L
R
S
L
Q
DWF
L
KYE
L
K
TIP
D
V
A
E
V
ASV
G
GVVKEY
QV
V
I
DP
QR
L
A
QYG
I
SLAE
V
KS
A
L
DAS
N
QEAGG
SSI
--
-
-
--ELAEAEYM
V
R
A
SGY
LQT
L
D
D
F
NH
I
V
L
KASE
N
G
VP
V
Y
L
R
DVA
K
V
Q
V
G
P
E
MRRGI
A
EL
NG
E
G
E
V
A
G
GV
V
I
L
RS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSS
L
P
E
GV
E
IVTT
YD
RS
QL
I
DR
A
I
D
N
LSGK
L
L
E
EF
I
V
V
A
V
V
C
A
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
I
V
M
H
F
Q
G
L
N
A
N
I
MSL
G
G
I
A
I
A
V
G
A
M
VD
A
AIV
MI
EN
AH
K
R
L
E
E
WQHQHPDATL
D
NKT
R
WQ
V
IT
D
ASV
EVG
P
AL
FISLLI
I
T
LS
FIP
I
F
T
LE
G
QE
G
R
LFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------L
N
RF
L
IRV---
----
Y
HPLLL
KVL
HWPKTT
L
L
V
A
A
L
SVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TD
K
--
LIMSVPE
V
A
R
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QD
QW
R
PG--MTMD
K
II
E
EL
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LST
G
IK
S
PIGIK
V
SGTVLADI
D
T
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
LE
GGRYIN
V
E
IN
RE
KA
A
R
Y
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DS
P
QA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YI
D
A
RDRD
M
V
S
V
V
HDLQKAIAEK
V
Q
LK
P
G
TSVA
F
S
G
--
-Q
FE
LL
E
RANHKLK
L
M
VP
M
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAI
E
AE
PSLNNPQTFSE
QKLD
EA
LYH
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
GAGS
E
VMSR
I
A
A
PM
I
GGM
IT
A
P
LL
S
L
F
II
P
AA
Y
K
L
M
WLHRHRVRK
fig|685038.3.peg.517
Escherichia coli O83:H1 str. NRG 857C
MIEWIIRR
S
VA
NRF
L
VLMG
A
L
F
L
S
I
W
G
TWT
I
IN
T
PV
D
AL
P
D
L
SD
V
Q
V
I
I
K
T
S
YPG
Q
A
P
Q
I
V
E
N
Q
VT
Y
PLT
TT
M
LS
V
P
G
AK
T
VRG
F
S
QF-
G
DSY
VYV
I
FE
D
GT
D
P
Y
W
A
RS
R
V
L
EY
L
N
Q
V
QGK
LP
A-----
GV
SAELGPDAT
GVG
W
I
YEY
A
LV
D
RSGKHDLA
D
L
R
S
L
Q
DWF
L
KYE
L
K
TIP
D
V
A
E
V
ASV
G
GVVKEY
QV
V
I
DP
QR
L
A
QYG
I
SLAE
V
KS
A
L
DAS
N
QEAGG
SSI
--
-
-
--ELAEAEYM
V
R
A
SGY
LQT
L
D
D
F
NH
I
V
L
KASE
N
G
VP
V
Y
L
R
DVA
K
V
Q
V
G
P
E
MRRGI
A
EL
NG
E
G
E
V
A
G
GV
V
I
L
RS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSS
L
P
E
GV
E
IVTT
YD
RS
QL
I
DR
A
I
D
N
LSGK
L
L
E
EF
I
V
V
A
V
V
C
A
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
I
V
M
H
F
Q
G
L
N
A
N
I
MSL
G
G
I
A
I
A
V
G
A
M
VD
A
AIV
MI
EN
AH
K
R
L
E
E
WQHQHPDATL
D
NKT
R
WQ
V
IT
D
ASV
EVG
P
AL
FISLLI
I
T
LS
FIP
I
F
T
LE
G
QE
G
R
LFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------L
N
RF
L
IRV---
----
Y
HPLLL
KVL
HWPKTT
L
L
V
A
A
L
SVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TD
K
--
LIMSVPE
V
A
R
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QD
QW
R
PG--MTMD
K
II
E
EL
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LST
G
IK
S
PIGIK
V
SGTVLADI
D
T
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
LE
GGRYIN
V
E
IN
RE
KA
A
R
Y
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DS
P
QA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YI
D
A
RDRD
M
V
S
V
V
HDLQKAIAEK
V
Q
LK
P
G
TSVA
F
S
G
--
-Q
FE
LL
E
RANHKLK
L
M
VP
M
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAI
E
AE
PSLNNPQTFSE
QKLD
EA
LYH
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
GAGS
E
VMSR
I
A
A
PM
I
GGM
IT
A
P
LL
S
L
F
II
P
AA
Y
K
L
M
WLHRHRVRK
fig|585035.6.peg.608
Escherichia coli S88
MIEWIIRR
S
VA
NRF
L
VLMG
A
L
F
L
S
I
W
G
TWT
I
IN
T
PV
D
AL
P
D
L
SD
V
Q
V
I
I
K
T
S
YPG
Q
A
P
Q
I
V
E
N
Q
VT
Y
PLT
TT
M
LS
V
P
G
AK
T
VRG
F
S
QF-
G
DSY
VYV
I
FE
D
GT
D
P
Y
W
A
RS
R
V
L
EY
L
N
Q
V
QGK
LP
A-----
GV
SAELGPDAT
GVG
W
I
YEY
A
LV
D
RSGKHDLA
D
L
R
S
L
Q
DWF
L
KYE
L
K
TIP
D
V
A
E
V
ASV
G
GVVKEY
QV
V
I
DP
QR
L
A
QYG
I
SLAE
V
KS
A
L
DAS
N
QEAGG
SSI
--
-
-
--ELAEAEYM
V
R
A
SGY
LQT
L
D
D
F
NH
I
V
L
KASE
N
G
VP
V
Y
L
R
DVA
K
V
Q
V
G
P
E
MRRGI
A
EL
NG
E
G
E
V
A
G
GV
V
I
L
RS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSS
L
P
E
GV
E
IVTT
YD
RS
QL
I
DR
A
I
D
N
LSGK
L
L
E
EF
I
V
V
A
V
V
C
A
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
I
V
M
H
F
Q
G
L
N
A
N
I
MSL
G
G
I
A
I
A
V
G
A
M
VD
A
AIV
MI
EN
AH
K
R
L
E
E
WQHQHPDATL
D
NKT
R
WQ
V
IT
D
ASV
EVG
P
AL
FISLLI
I
T
LS
FIP
I
F
T
LE
G
QE
G
R
LFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------L
N
RF
L
IRV---
----
Y
HPLLL
KVL
HWPKTT
L
L
V
A
A
L
SVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TD
K
--
LIMSVPE
V
A
R
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QD
QW
R
PG--MTMD
K
II
E
EL
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LST
G
IK
S
PIGIK
V
SGTVLADI
D
T
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
LE
GGRYIN
V
E
IN
RE
KA
A
R
Y
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DS
P
QA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YI
D
A
RDRD
M
V
S
V
V
HDLQKAIAEK
V
Q
LK
P
G
TSVA
F
S
G
--
-Q
FE
LL
E
RANHKLK
L
M
VP
M
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAI
E
AE
PSLNNPQTFSE
QKLD
EA
LYH
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
GAGS
E
VMSR
I
A
A
PM
I
GGM
IT
A
P
LL
S
L
F
II
P
AA
Y
K
L
M
WLHRHRVRK
fig|439855.10.peg.762
Escherichia coli SMS-3-5
MIEWIIRR
S
VA
NRF
L
VLMG
A
L
F
L
S
I
W
G
TWT
I
IN
T
PV
D
AL
P
D
L
SD
V
Q
V
I
I
K
T
S
YPG
Q
A
P
Q
I
V
E
N
Q
VT
Y
PLT
TT
M
LS
V
P
G
AK
T
VRG
F
S
QF-
G
DSY
VYV
I
FE
D
GT
D
P
Y
W
A
RS
R
V
L
EY
L
N
Q
V
QGK
LP
A-----
GV
SAELGPDAT
GVG
W
I
YEY
A
LV
D
RSGKHDLA
D
L
R
S
L
Q
DWF
L
KYE
L
K
TIP
D
V
A
E
V
ASV
G
GVVKEY
QV
V
I
DP
QR
L
A
QYG
I
SLAE
V
KS
A
L
DAS
N
QEAGG
SSI
--
-
-
--ELAEAEYM
V
R
A
SGY
LQT
L
D
D
F
NH
I
V
L
KASE
N
G
VP
V
Y
L
R
DVA
K
V
Q
V
G
P
E
MRRGI
A
EL
NG
E
G
E
V
A
G
GV
V
I
L
RS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSS
L
P
E
GV
E
IVTT
YD
RS
QL
I
DR
A
I
D
N
LSGK
L
L
E
EF
I
V
V
A
V
V
C
A
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
I
V
M
H
F
Q
G
L
N
A
N
I
MSL
G
G
I
A
I
A
V
G
A
M
VD
A
AIV
MI
EN
AH
K
R
L
E
E
WQHQHPDATL
D
NKT
R
WQ
V
IT
D
ASV
EVG
P
AL
FISLLI
I
T
LS
FIP
I
F
T
LE
G
QE
G
R
LFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------L
N
RF
L
IRV---
----
Y
HPLLL
KVL
HWPKTT
L
L
V
A
A
L
SVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TD
K
--
LIMSVPE
V
A
R
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QD
QW
R
PG--MTMD
K
II
E
EL
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LST
G
IK
S
PIGIK
V
SGTVLADI
D
T
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
LE
GGRYIN
V
E
IN
RE
KA
A
R
Y
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DS
P
QA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YI
D
A
RDRD
M
V
S
V
V
HDLQKAIAEK
V
Q
LK
P
G
TSVA
F
S
G
--
-Q
FE
LL
E
RANHKLK
L
M
VP
M
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAI
E
AE
PSLNNPQTFSE
QKLD
EA
LYH
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
GAGS
E
VMSR
I
A
A
PM
I
GGM
IT
A
P
LL
S
L
F
II
P
AA
Y
K
L
M
WLHRHRVRK
fig|562.376.peg.2042
Escherichia coli WV_060327
MIEWIIRR
S
VA
NRF
L
VLMG
A
L
F
L
S
I
W
G
TWT
I
IN
T
PV
D
AL
P
D
L
SD
V
Q
V
I
I
K
T
S
YPG
Q
A
P
Q
I
V
E
N
Q
VT
Y
PLT
TT
M
LS
V
P
G
AK
T
VRG
F
S
QF-
G
DSY
VYV
I
FE
D
GT
D
P
Y
W
A
RS
R
V
L
EY
L
N
Q
V
QGK
LP
A-----
GV
SAELGPDAT
GVG
W
I
YEY
A
LV
D
RSGKHDLA
D
L
R
S
L
Q
DWF
L
KYE
L
K
TIP
D
V
A
E
V
ASV
G
GVVKEY
QV
V
I
DP
QR
L
A
QYG
I
SLAE
V
KS
A
L
DAS
N
QEAGG
SSI
--
-
-
--ELAEAEYM
V
R
A
SGY
LQT
L
D
D
F
NH
I
V
L
KASE
N
G
VP
V
Y
L
R
DVA
K
V
Q
V
G
P
E
MRRGI
A
EL
NG
E
G
E
V
A
G
GV
V
I
L
RS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSS
L
P
E
GV
E
IVTT
YD
RS
QL
I
DR
A
I
D
N
LSGK
L
L
E
EF
I
V
V
A
V
V
C
A
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
I
V
M
H
F
Q
G
L
N
A
N
I
MSL
G
G
I
A
I
A
V
G
A
M
VD
A
AIV
MI
EN
AH
K
R
L
E
E
WQHQHPDATL
D
NKT
R
WQ
V
IT
D
ASV
EVG
P
AL
FISLLI
I
T
LS
FIP
I
F
T
LE
G
QE
G
R
LFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------L
N
RF
L
IRV---
----
Y
HPLLL
KVL
HWPKTT
L
L
V
A
A
L
SVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TD
K
--
LIMSVPE
V
A
R
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QD
QW
R
PG--MTMD
K
II
E
EL
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LST
G
IK
S
PIGIK
V
SGTVLADI
D
T
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
LE
GGRYIN
V
E
IN
RE
KA
A
R
Y
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DS
P
QA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YI
D
A
RDRD
M
V
S
V
V
HDLQKAIAEK
V
Q
LK
P
G
TSVA
F
S
G
--
-Q
FE
LL
E
RANHKLK
L
M
VP
M
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAI
E
AE
PSLNNPQTFSE
QKLD
EA
LYH
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
GAGS
E
VMSR
I
A
A
PM
I
GGM
IT
A
P
LL
S
L
F
II
P
AA
Y
K
L
M
WLHRHRVRK
fig|340186.3.peg.2228
Escherichia coli E110019
MIEWIIRR
S
VA
NRF
L
VLMG
A
L
F
L
S
I
W
G
TWT
I
IN
T
PV
D
AL
P
D
L
SD
V
Q
V
I
I
K
T
S
YPG
Q
A
P
Q
I
V
E
N
Q
VT
Y
PLT
TT
M
LS
V
P
G
AK
T
VRG
F
S
QF-
G
DSY
VYV
I
FE
D
GT
D
P
Y
W
A
RS
R
V
L
EY
L
N
Q
V
QGK
LP
A-----
GV
SAELGPDAT
GVG
W
I
YEY
A
LV
D
RSGKHDLA
D
L
R
S
L
Q
DWF
L
KYE
L
K
TIP
D
V
A
E
V
ASV
G
GVVKEY
QV
V
I
DP
QR
L
A
QYG
I
SLAE
V
KS
A
L
DAS
N
QEAGG
SSI
--
-
-
--ELAEAEYM
V
R
A
SGY
LQT
L
D
D
F
NH
I
V
L
KASE
N
G
VP
V
Y
L
R
DVA
K
V
Q
I
G
P
E
TRRGI
A
EL
NG
E
G
E
V
A
G
GV
V
I
L
RS
G
K
N
ARE
V
IAS
V
KDK
L
ET
L
KSS
L
P
E
GV
E
IVTT
YD
RS
QL
I
DR
A
I
D
N
LSGK
L
L
E
EF
I
V
V
A
V
V
C
A
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
I
V
M
H
F
Q
G
L
N
A
N
I
MSL
G
G
I
A
I
A
V
G
A
M
VD
A
AIV
MI
EN
AH
K
R
L
E
E
WQHQHPDATL
D
NKT
R
WQ
V
IT
D
ASV
EVG
P
AL
FISLLI
I
T
LS
FIP
I
F
T
LE
G
QE
G
R
LFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------L
N
RF
L
IRV---
----
Y
HPLLL
KVL
HWPKTT
L
L
V
A
A
L
SVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TD
K
--
LIMSVPE
V
A
R
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMD
K
II
E
EL
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LST
G
IK
S
PIGIK
V
SGTVLADI
D
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
LE
GGRYIN
V
E
IN
RE
KA
A
R
Y
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DS
P
QA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YI
D
A
RDRD
M
V
S
V
V
HDLQKAIAEK
V
Q
LK
P
G
TSVA
F
S
G
--
-Q
FE
LL
E
RANHKLK
L
M
VP
M
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAI
E
AE
PSLNNPQTFSE
QKLD
EA
LYH
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
GAGS
E
VMSR
I
A
A
PM
I
GGM
IT
A
P
LL
S
L
F
II
P
AA
Y
K
L
M
WLHRHRVRK
fig|340186.5.peg.2300
Escherichia coli E110019
MIEWIIRR
S
VA
NRF
L
VLMG
A
L
F
L
S
I
W
G
TWT
I
IN
T
PV
D
AL
P
D
L
SD
V
Q
V
I
I
K
T
S
YPG
Q
A
P
Q
I
V
E
N
Q
VT
Y
PLT
TT
M
LS
V
P
G
AK
T
VRG
F
S
QF-
G
DSY
VYV
I
FE
D
GT
D
P
Y
W
A
RS
R
V
L
EY
L
N
Q
V
QGK
LP
A-----
GV
SAELGPDAT
GVG
W
I
YEY
A
LV
D
RSGKHDLA
D
L
R
S
L
Q
DWF
L
KYE
L
K
TIP
D
V
A
E
V
ASV
G
GVVKEY
QV
V
I
DP
QR
L
A
QYG
I
SLAE
V
KS
A
L
DAS
N
QEAGG
SSI
--
-
-
--ELAEAEYM
V
R
A
SGY
LQT
L
D
D
F
NH
I
V
L
KASE
N
G
VP
V
Y
L
R
DVA
K
V
Q
I
G
P
E
TRRGI
A
EL
NG
E
G
E
V
A
G
GV
V
I
L
RS
G
K
N
ARE
V
IAS
V
KDK
L
ET
L
KSS
L
P
E
GV
E
IVTT
YD
RS
QL
I
DR
A
I
D
N
LSGK
L
L
E
EF
I
V
V
A
V
V
C
A
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
I
V
M
H
F
Q
G
L
N
A
N
I
MSL
G
G
I
A
I
A
V
G
A
M
VD
A
AIV
MI
EN
AH
K
R
L
E
E
WQHQHPDATL
D
NKT
R
WQ
V
IT
D
ASV
EVG
P
AL
FISLLI
I
T
LS
FIP
I
F
T
LE
G
QE
G
R
LFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------L
N
RF
L
IRV---
----
Y
HPLLL
KVL
HWPKTT
L
L
V
A
A
L
SVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TD
K
--
LIMSVPE
V
A
R
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMD
K
II
E
EL
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LST
G
IK
S
PIGIK
V
SGTVLADI
D
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
LE
GGRYIN
V
E
IN
RE
KA
A
R
Y
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DS
P
QA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YI
D
A
RDRD
M
V
S
V
V
HDLQKAIAEK
V
Q
LK
P
G
TSVA
F
S
G
--
-Q
FE
LL
E
RANHKLK
L
M
VP
M
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAI
E
AE
PSLNNPQTFSE
QKLD
EA
LYH
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
GAGS
E
VMSR
I
A
A
PM
I
GGM
IT
A
P
LL
S
L
F
II
P
AA
Y
K
L
M
WLHRHRVRK
fig|413997.3.peg.563
Escherichia coli B str. REL606
MIEWIIRR
S
VA
NRF
L
VLMG
A
L
F
L
S
I
W
G
TWT
I
IN
T
PV
D
AL
P
D
L
SD
V
Q
V
I
I
K
T
S
YPG
Q
A
P
Q
I
V
E
N
Q
VT
Y
PLT
TT
M
LS
V
P
G
AK
T
VRG
F
S
QF-
G
DSY
VYV
I
FE
D
GT
D
P
Y
W
A
RS
R
V
L
EY
L
N
Q
V
QGK
LP
A-----
GV
SAELGPDAT
GVG
W
I
YEY
A
LV
D
RSGKHDLA
D
L
R
S
L
Q
DWF
L
KYE
L
K
TIP
D
V
A
E
V
ASV
G
GVVKEY
QV
V
I
DP
QR
L
A
QYG
I
SLAE
V
KS
A
L
DAS
N
QEAGG
SSI
--
-
-
--ELAEAEYM
V
R
A
SGY
LQT
L
D
D
F
NH
I
V
L
KASE
N
G
VP
V
Y
L
R
DVA
K
V
Q
I
G
P
E
MRRGI
A
EL
NG
E
G
E
V
A
G
GV
V
I
L
RS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSS
L
P
E
GV
E
IVTT
YD
RS
QL
I
DR
A
I
D
N
LSGK
L
L
E
EF
I
M
V
A
V
V
C
A
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
I
V
M
H
F
Q
G
L
N
A
N
I
MSL
G
G
I
A
I
A
V
G
A
M
VD
A
AIV
MI
EN
AH
K
R
L
E
E
WQHQHPDATL
D
NKT
R
WQ
V
IT
D
ASV
EVG
P
AL
FISLLI
I
T
LS
FIP
I
F
T
LE
G
QE
G
R
LFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------L
N
RF
L
IRV---
----
Y
HPLLL
KVL
HWPKTT
L
L
V
A
A
L
SVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TD
K
--
LIMSVPE
V
A
R
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMD
K
II
E
EL
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LST
G
IK
S
PIGIK
V
SGTVLADI
D
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
LE
GGRYIN
V
E
IN
RE
KA
A
R
Y
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DS
P
QA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DIKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YI
D
A
RDRD
M
V
S
V
V
HDLQKAIAEK
V
Q
LK
P
G
TSVA
F
S
G
--
-Q
FE
LL
E
RANHKLK
L
M
VP
M
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAI
E
AV
PSLNNPQTFSE
QKLD
EA
LYH
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
GAGS
E
VMSR
I
A
A
PM
I
GGM
IT
A
P
LL
S
L
F
II
P
AA
Y
K
L
M
WLHRHRVRK
fig|511693.5.peg.558
Escherichia coli BL21
MIEWIIRR
S
VA
NRF
L
VLMG
A
L
F
L
S
I
W
G
TWT
I
IN
T
PV
D
AL
P
D
L
SD
V
Q
V
I
I
K
T
S
YPG
Q
A
P
Q
I
V
E
N
Q
VT
Y
PLT
TT
M
LS
V
P
G
AK
T
VRG
F
S
QF-
G
DSY
VYV
I
FE
D
GT
D
P
Y
W
A
RS
R
V
L
EY
L
N
Q
V
QGK
LP
A-----
GV
SAELGPDAT
GVG
W
I
YEY
A
LV
D
RSGKHDLA
D
L
R
S
L
Q
DWF
L
KYE
L
K
TIP
D
V
A
E
V
ASV
G
GVVKEY
QV
V
I
DP
QR
L
A
QYG
I
SLAE
V
KS
A
L
DAS
N
QEAGG
SSI
--
-
-
--ELAEAEYM
V
R
A
SGY
LQT
L
D
D
F
NH
I
V
L
KASE
N
G
VP
V
Y
L
R
DVA
K
V
Q
I
G
P
E
MRRGI
A
EL
NG
E
G
E
V
A
G
GV
V
I
L
RS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSS
L
P
E
GV
E
IVTT
YD
RS
QL
I
DR
A
I
D
N
LSGK
L
L
E
EF
I
M
V
A
V
V
C
A
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
I
V
M
H
F
Q
G
L
N
A
N
I
MSL
G
G
I
A
I
A
V
G
A
M
VD
A
AIV
MI
EN
AH
K
R
L
E
E
WQHQHPDATL
D
NKT
R
WQ
V
IT
D
ASV
EVG
P
AL
FISLLI
I
T
LS
FIP
I
F
T
LE
G
QE
G
R
LFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------L
N
RF
L
IRV---
----
Y
HPLLL
KVL
HWPKTT
L
L
V
A
A
L
SVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TD
K
--
LIMSVPE
V
A
R
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMD
K
II
E
EL
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LST
G
IK
S
PIGIK
V
SGTVLADI
D
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
LE
GGRYIN
V
E
IN
RE
KA
A
R
Y
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DS
P
QA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DIKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YI
D
A
RDRD
M
V
S
V
V
HDLQKAIAEK
V
Q
LK
P
G
TSVA
F
S
G
--
-Q
FE
LL
E
RANHKLK
L
M
VP
M
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAI
E
AV
PSLNNPQTFSE
QKLD
EA
LYH
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
GAGS
E
VMSR
I
A
A
PM
I
GGM
IT
A
P
LL
S
L
F
II
P
AA
Y
K
L
M
WLHRHRVRK
fig|469008.4.peg.3196
Escherichia coli BL21(DE3)
MIEWIIRR
S
VA
NRF
L
VLMG
A
L
F
L
S
I
W
G
TWT
I
IN
T
PV
D
AL
P
D
L
SD
V
Q
V
I
I
K
T
S
YPG
Q
A
P
Q
I
V
E
N
Q
VT
Y
PLT
TT
M
LS
V
P
G
AK
T
VRG
F
S
QF-
G
DSY
VYV
I
FE
D
GT
D
P
Y
W
A
RS
R
V
L
EY
L
N
Q
V
QGK
LP
A-----
GV
SAELGPDAT
GVG
W
I
YEY
A
LV
D
RSGKHDLA
D
L
R
S
L
Q
DWF
L
KYE
L
K
TIP
D
V
A
E
V
ASV
G
GVVKEY
QV
V
I
DP
QR
L
A
QYG
I
SLAE
V
KS
A
L
DAS
N
QEAGG
SSI
--
-
-
--ELAEAEYM
V
R
A
SGY
LQT
L
D
D
F
NH
I
V
L
KASE
N
G
VP
V
Y
L
R
DVA
K
V
Q
I
G
P
E
MRRGI
A
EL
NG
E
G
E
V
A
G
GV
V
I
L
RS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSS
L
P
E
GV
E
IVTT
YD
RS
QL
I
DR
A
I
D
N
LSGK
L
L
E
EF
I
M
V
A
V
V
C
A
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
I
V
M
H
F
Q
G
L
N
A
N
I
MSL
G
G
I
A
I
A
V
G
A
M
VD
A
AIV
MI
EN
AH
K
R
L
E
E
WQHQHPDATL
D
NKT
R
WQ
V
IT
D
ASV
EVG
P
AL
FISLLI
I
T
LS
FIP
I
F
T
LE
G
QE
G
R
LFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------L
N
RF
L
IRV---
----
Y
HPLLL
KVL
HWPKTT
L
L
V
A
A
L
SVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TD
K
--
LIMSVPE
V
A
R
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMD
K
II
E
EL
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LST
G
IK
S
PIGIK
V
SGTVLADI
D
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
LE
GGRYIN
V
E
IN
RE
KA
A
R
Y
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DS
P
QA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DIKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YI
D
A
RDRD
M
V
S
V
V
HDLQKAIAEK
V
Q
LK
P
G
TSVA
F
S
G
--
-Q
FE
LL
E
RANHKLK
L
M
VP
M
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAI
E
AV
PSLNNPQTFSE
QKLD
EA
LYH
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
GAGS
E
VMSR
I
A
A
PM
I
GGM
IT
A
P
LL
S
L
F
II
P
AA
Y
K
L
M
WLHRHRVRK
fig|749545.3.peg.4929
Escherichia coli MS 182-1
MIEWIIRR
S
VA
NRF
L
VLMG
A
L
F
L
S
I
W
G
TWT
I
IN
T
PV
D
AL
P
D
L
SD
V
Q
V
I
I
K
T
S
YPG
Q
A
P
Q
I
V
E
N
Q
VT
Y
PLT
TT
M
LS
V
P
G
AK
T
VRG
F
S
QF-
G
DSY
VYV
I
FE
D
GT
D
P
Y
W
A
RS
R
V
L
EY
L
N
Q
V
QGK
LP
A-----
GV
SAELGPDAT
GVG
W
I
YEY
A
LV
D
RSGKHDLA
D
L
R
S
L
Q
DWF
L
KYE
L
K
TIP
D
V
A
E
V
ASV
G
GVVKEY
QV
V
I
DP
QR
L
A
QYG
I
SLAE
V
KS
A
L
DAS
N
QEAGG
SSI
--
-
-
--ELAEAEYM
V
R
A
SGY
LQT
L
D
D
F
NH
I
V
L
KASE
N
G
VP
V
Y
L
R
DVA
K
V
Q
I
G
P
E
MRRGI
A
EL
NG
E
G
E
V
A
G
GV
V
I
L
RS
G
K
T
ARE
V
IAA
V
KDK
L
ET
L
KSS
L
P
E
GV
E
IVTT
YD
RS
QL
I
DR
A
I
D
N
LSGK
L
L
E
EF
I
V
V
A
V
V
C
A
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
I
V
M
H
F
Q
G
L
N
A
N
I
MSL
G
G
I
A
I
A
V
G
A
M
VD
A
AIV
MI
EN
AH
K
R
L
E
E
WQHQHPDATL
D
NKT
R
WQ
V
IT
D
ASV
EVG
P
AL
FISLLI
I
T
LS
FIP
I
F
T
LE
G
QE
G
R
LFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------L
N
RF
L
IRV---
----
Y
HPLLL
KVL
HWPKTT
L
L
V
A
A
L
SVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TD
K
--
LIMSVPE
V
A
R
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QD
QW
R
PG--MTMD
K
II
E
EL
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LST
G
IK
S
PIGIK
V
SGTVLADI
D
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
LE
GGRYIN
V
E
IN
RE
KA
A
R
Y
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DS
P
QA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YI
D
A
RDRD
M
V
S
V
V
HDLQKAIAEK
V
Q
LK
P
G
TSVA
F
S
G
--
-Q
FE
LL
E
RANHKLK
L
M
VP
M
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAI
E
AE
PSLNNPQTFSE
QKLD
EA
LYH
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
GAGS
E
VMSR
I
A
A
PM
I
GGM
IT
A
P
LL
S
L
F
II
P
AA
Y
K
L
M
WLHRHRVRK
fig|656437.3.peg.647
Escherichia coli TA143
MIEWIIRR
S
VA
NRF
L
VLMG
A
L
F
L
S
I
W
G
TWT
I
IN
T
PV
D
AL
P
D
L
SD
V
Q
V
I
I
K
T
S
YPG
Q
A
P
Q
I
V
E
N
Q
VT
Y
PLT
TT
M
LS
V
P
G
AK
T
VRG
F
S
QF-
G
DSY
VYV
I
FE
D
GT
D
P
Y
W
A
RS
R
V
L
EY
L
N
Q
V
QGK
LP
A-----
GV
SAELGPDAT
GVG
W
I
YEY
A
LV
D
RSGKHDLA
D
L
R
S
L
Q
DWF
L
KYE
L
K
TIP
D
V
A
E
V
ASV
G
GVVKEY
QV
V
I
DP
QR
L
A
QYG
I
SLAE
V
KS
A
L
DAS
N
QEAGG
SSI
--
-
-
--ELAEAEYM
V
R
A
SGY
LQT
L
D
D
F
NH
I
V
L
KASE
N
G
VP
V
Y
L
R
DVA
K
V
Q
I
G
P
E
MRRGI
A
EL
NG
E
G
E
V
A
G
GV
V
I
L
RS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSS
L
P
E
GV
E
IVTT
YD
RS
QL
I
DR
A
I
D
N
LSGK
L
L
E
EF
I
V
V
A
V
V
C
A
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
I
V
M
H
F
Q
G
L
N
A
N
I
MSL
G
G
I
A
I
A
V
G
A
M
VD
A
AIV
MI
EN
AH
K
R
L
E
E
WQHQHPDATL
D
NKT
R
WQ
V
IT
D
ASV
EVG
P
AL
FISLLI
I
T
LS
FIP
I
F
T
LE
G
QE
G
R
LFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
I
VI
P
I
L
MG
YW
I
RGKIPPESSNP------L
N
RF
L
IRA---
----
Y
HPLLL
KVL
HWPKTT
L
L
V
A
A
L
SVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TD
K
--
LIMSVPE
V
A
R
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QD
QW
R
PG--MTMD
K
II
E
EL
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LST
G
IK
S
PIGIK
V
SGTVLADI
D
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
LE
GGRYIN
V
E
IN
RE
KA
A
R
Y
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DS
P
QA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YI
D
A
RDRD
M
V
S
V
V
HDLQKAIAEK
V
Q
LK
P
G
TSVA
F
S
G
--
-Q
FE
LL
E
RANHKLK
L
M
VP
M
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAI
E
AE
PSLNNPQTFSE
QKLD
EA
LYH
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
GAGS
E
VMSR
I
A
A
PM
I
GGM
IT
A
P
M
L
S
L
F
II
P
AA
Y
K
L
M
WLHRHRVRK
fig|656393.3.peg.1249
Escherichia coli H299
MIEWIIRR
S
VA
NRF
L
VLMG
A
L
F
L
S
I
W
G
TWT
I
IN
T
PV
D
AL
P
D
L
SD
V
Q
V
I
I
K
T
S
YPG
Q
A
P
Q
I
V
E
N
Q
VT
Y
PLT
TT
M
LS
V
P
G
AK
T
VRG
F
S
QF-
G
DSY
VYV
I
FE
D
GT
D
P
Y
W
A
RS
R
V
L
EY
L
N
Q
V
QGK
LP
A-----
GV
SAELGPDAT
GVG
W
I
YEY
A
LV
D
RSGKHDLA
D
L
R
S
L
Q
DWF
L
KYE
L
K
TIP
D
V
A
E
V
ASV
G
GVVKEY
QV
V
I
DP
QR
L
A
QYG
I
SLAE
V
KS
A
L
DAS
N
QEAGG
SSI
--
-
-
--ELAEAEYM
V
R
A
SGY
LQT
L
D
D
F
NH
I
V
L
KASE
N
G
VP
V
Y
L
R
DVA
K
V
Q
I
G
P
E
MRRGI
A
EL
NG
E
G
E
V
A
G
GV
V
I
L
RS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSS
L
P
E
GV
E
IVTT
YD
RS
QL
I
DR
A
I
D
N
LSGK
L
L
E
EF
I
V
V
A
V
V
C
A
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
I
V
M
H
F
Q
G
L
N
A
N
I
MSL
G
G
I
A
I
A
V
G
A
M
VD
A
AIV
MI
EN
AH
K
R
L
E
E
WQHQHPDATL
D
NKT
R
WQ
V
IT
D
ASV
EVG
P
AL
FISLLI
I
T
LS
FIP
I
F
T
LE
G
QE
G
R
LFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------L
N
RF
L
IRV---
----
Y
HPLLL
KVL
HWPKTT
L
L
V
A
A
L
SVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TD
K
--
LIMSVPE
V
A
R
VF
GKT
G
KAETTTDS
A
PLEMV
ETT
I
Q
LKP
QD
QW
R
PG--MTMD
K
II
E
EL
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LST
G
IK
S
PIGIK
V
SGTVLADI
D
T
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
LE
GGRYIN
V
E
IN
RE
KA
A
R
Y
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DS
P
QA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YI
D
A
RDRD
M
V
S
V
V
HDLQKAIAEK
V
Q
LK
P
G
TSVA
F
S
G
--
-Q
FE
LL
E
RANHKLK
L
M
VP
M
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAI
E
AE
PSLNNPQTFSE
QKLD
EA
LYH
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
GAGS
E
VMSR
I
A
A
PM
I
GGM
IT
A
P
LL
S
L
F
II
P
AA
Y
K
L
M
WLHRHRVRK
fig|525281.3.peg.2364
Escherichia coli 83972
MIEWIIRR
S
V
S
NRF
L
VLMG
A
L
F
L
S
I
W
G
TWT
I
IN
T
PV
D
AL
P
D
L
SD
V
Q
V
I
I
K
T
S
YPG
Q
A
P
Q
I
V
E
N
Q
VT
Y
PLT
TT
M
LS
V
P
G
AK
T
VRG
F
S
QF-
G
DSY
VYV
I
FE
D
GT
D
P
Y
W
A
RS
R
V
L
EY
L
N
Q
V
QGK
LP
A-----
GV
SAELGPDAT
GVG
W
I
YEY
A
LV
D
RSGKHDLA
D
L
R
S
L
Q
DWF
L
KYE
L
K
TIP
D
V
A
E
V
ASV
G
GVVKEY
QV
V
I
DP
QR
L
A
QYG
I
SLAE
V
KS
A
L
DAS
N
QEAGG
SSI
--
-
-
--ELAEAEYM
V
R
A
SGY
LQT
L
D
D
F
NH
I
V
L
KASE
N
G
VP
V
Y
L
R
DVA
K
V
Q
V
G
P
E
MRRGI
A
EL
NG
E
G
E
V
A
G
GV
V
I
L
RS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSS
L
P
E
GV
E
IVTT
YD
RS
QL
I
DR
A
I
D
N
LSGK
L
L
E
EF
I
V
V
A
V
V
C
A
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
I
V
M
H
F
Q
G
L
N
A
N
I
MSL
G
G
I
A
I
A
V
G
A
M
VD
A
AIV
MI
EN
AH
K
R
L
E
E
WQHQHPDATL
D
NKT
R
WQ
V
IT
D
ASV
EVG
P
AL
FISLLI
I
T
LS
FIP
I
F
T
LE
G
QE
G
R
LFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------L
N
RF
L
IRV---
----
Y
HPLLL
KVL
HWPKTT
L
L
V
A
A
L
SVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TD
K
--
LIMSVPE
V
A
R
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QD
QW
R
PG--MTMD
K
II
E
EL
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LST
G
IK
S
PIGIK
V
SGTVLADI
D
T
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
LE
GGRYIN
V
E
IN
RE
KA
A
R
Y
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DS
P
QA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YI
D
A
RDRD
M
V
S
V
V
HDLQKAIAEK
V
Q
LK
P
G
TSVA
F
S
G
--
-Q
FE
LL
E
RANHKLK
L
M
VP
M
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAI
E
AE
PSLNNPQTFSE
QKLD
EA
LYH
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
GAGS
E
VMSR
I
A
A
PM
I
GGM
IT
A
P
LL
S
L
F
II
P
AA
Y
K
L
M
WLHRHRVRK
fig|655817.3.peg.665
Escherichia coli ABU 83972
MIEWIIRR
S
V
S
NRF
L
VLMG
A
L
F
L
S
I
W
G
TWT
I
IN
T
PV
D
AL
P
D
L
SD
V
Q
V
I
I
K
T
S
YPG
Q
A
P
Q
I
V
E
N
Q
VT
Y
PLT
TT
M
LS
V
P
G
AK
T
VRG
F
S
QF-
G
DSY
VYV
I
FE
D
GT
D
P
Y
W
A
RS
R
V
L
EY
L
N
Q
V
QGK
LP
A-----
GV
SAELGPDAT
GVG
W
I
YEY
A
LV
D
RSGKHDLA
D
L
R
S
L
Q
DWF
L
KYE
L
K
TIP
D
V
A
E
V
ASV
G
GVVKEY
QV
V
I
DP
QR
L
A
QYG
I
SLAE
V
KS
A
L
DAS
N
QEAGG
SSI
--
-
-
--ELAEAEYM
V
R
A
SGY
LQT
L
D
D
F
NH
I
V
L
KASE
N
G
VP
V
Y
L
R
DVA
K
V
Q
V
G
P
E
MRRGI
A
EL
NG
E
G
E
V
A
G
GV
V
I
L
RS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSS
L
P
E
GV
E
IVTT
YD
RS
QL
I
DR
A
I
D
N
LSGK
L
L
E
EF
I
V
V
A
V
V
C
A
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
I
V
M
H
F
Q
G
L
N
A
N
I
MSL
G
G
I
A
I
A
V
G
A
M
VD
A
AIV
MI
EN
AH
K
R
L
E
E
WQHQHPDATL
D
NKT
R
WQ
V
IT
D
ASV
EVG
P
AL
FISLLI
I
T
LS
FIP
I
F
T
LE
G
QE
G
R
LFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------L
N
RF
L
IRV---
----
Y
HPLLL
KVL
HWPKTT
L
L
V
A
A
L
SVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TD
K
--
LIMSVPE
V
A
R
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QD
QW
R
PG--MTMD
K
II
E
EL
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LST
G
IK
S
PIGIK
V
SGTVLADI
D
T
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
LE
GGRYIN
V
E
IN
RE
KA
A
R
Y
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DS
P
QA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YI
D
A
RDRD
M
V
S
V
V
HDLQKAIAEK
V
Q
LK
P
G
TSVA
F
S
G
--
-Q
FE
LL
E
RANHKLK
L
M
VP
M
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAI
E
AE
PSLNNPQTFSE
QKLD
EA
LYH
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
GAGS
E
VMSR
I
A
A
PM
I
GGM
IT
A
P
LL
S
L
F
II
P
AA
Y
K
L
M
WLHRHRVRK
fig|656417.3.peg.694
Escherichia coli M605
MIEWIIRR
S
VA
NRF
L
VLMG
A
L
F
L
S
I
W
G
TWT
I
IN
T
PV
D
AL
P
D
L
SD
V
Q
V
I
I
K
T
S
YPG
Q
A
P
Q
I
V
E
N
Q
VT
Y
PLT
TT
M
LS
V
P
G
AK
T
VRG
F
S
QF-
G
DSY
VYV
I
FE
D
GT
D
P
Y
W
A
RS
R
V
L
EY
L
N
Q
V
QGK
LP
A-----
GV
SAELGPDAT
GVG
W
I
YEY
A
LV
D
RSGKHDLA
D
L
R
S
L
Q
DWF
L
KYE
L
K
TIP
D
V
A
E
V
ASV
G
GVVKEY
QV
V
I
DP
QR
L
A
QYG
I
SLAD
V
KS
A
L
DAS
N
QEAGG
SSI
--
-
-
--ELAEAEYM
V
R
A
SGY
LQT
L
D
D
F
NH
I
V
L
KASE
N
G
VP
V
Y
L
R
DVA
K
V
Q
V
G
P
E
MRRGI
A
EL
NG
E
G
E
V
A
G
GV
V
I
L
RS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSS
L
P
E
GV
E
IVTT
YD
RS
QL
I
DR
A
I
D
N
LSGK
L
L
E
EF
I
V
V
A
V
V
C
A
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
I
V
M
H
F
Q
G
L
N
A
N
I
MSL
G
G
I
A
I
A
V
G
A
M
VD
A
AIV
MI
EN
AH
K
R
L
E
E
WQHQHPDATL
D
NKT
R
WQ
V
IT
D
ASV
EVG
P
AL
FISLLI
I
T
LS
FIP
I
F
T
LE
G
QE
G
R
LFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------L
N
RF
L
IRV---
----
Y
HPLLL
KVL
HWPKTT
L
L
V
A
A
L
SVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TD
K
--
LIMSVPE
V
A
R
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QD
QW
R
PG--MTMD
K
II
E
EL
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LST
G
IK
S
PIGIK
V
SGTVLADI
D
T
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
LE
GGRYIN
V
E
IN
RE
KA
A
R
Y
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DS
P
QA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YI
D
A
RDRD
M
V
S
V
V
HDLQKAIAEK
V
Q
LK
P
G
TSVA
F
S
G
--
-Q
FE
LL
E
RANHKLK
L
M
VP
M
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAI
E
AE
PSLNNPQTFSE
QKLD
EA
LYH
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
GAGS
E
VMSR
I
A
A
PM
I
GGM
IT
A
P
LL
S
L
F
II
P
AA
Y
K
L
M
WLHRHRVRK
fig|656440.3.peg.427
Escherichia coli TA206
MIEWIIRR
S
VA
NRF
L
VLMG
A
L
F
L
S
I
W
G
TWT
I
IN
T
PV
D
AL
P
D
L
SD
V
Q
V
I
I
K
T
S
YPG
Q
A
P
Q
I
V
E
N
Q
VT
Y
PLT
TT
M
LS
V
P
G
AK
T
VRG
F
S
QF-
G
DSY
VYV
I
FE
D
GT
D
P
Y
W
A
RS
R
V
L
EY
L
N
Q
V
QGK
LP
A-----
GV
SAELGPDAT
GVG
W
I
YEY
A
LV
D
RSGKHDLA
D
L
R
S
L
Q
DWF
L
KYE
L
K
TIP
D
V
A
E
V
ASV
G
GVVKEY
QV
V
I
DP
QR
L
A
QYG
I
SLAE
V
KS
A
L
DAS
N
QEAGG
SSI
--
-
-
--ELAEAEYM
V
R
A
SGY
LQT
L
D
D
F
NH
I
V
L
KASE
N
G
VP
V
Y
L
R
DVA
K
V
Q
V
G
P
E
MRRGI
A
EL
NG
E
G
E
V
A
G
GV
V
I
L
RS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSS
L
P
E
GV
E
IVTT
YD
RS
QL
I
DR
A
I
D
N
LSGK
L
L
E
EF
I
V
V
A
V
V
C
A
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
I
V
M
H
F
Q
G
L
N
A
N
I
MSL
G
G
I
A
I
A
V
G
A
M
VD
A
AIV
MI
EN
AH
K
R
L
E
E
WQHQHPDATL
D
NKT
R
WQ
V
IT
D
ASV
EVG
P
AL
FISLLI
I
T
LS
FIP
I
F
T
LE
G
QE
G
R
LFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------L
N
RF
L
IRV---
----
Y
HPLLL
KVL
HWPKTT
L
L
V
A
A
L
SVLTALW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TD
K
--
LIMSVPE
V
A
R
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QD
QW
R
PG--MTMD
K
II
E
EL
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LST
G
IK
S
PIGIK
V
SGTVLADI
D
T
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
LE
GGRYIN
V
E
IN
RE
KA
A
R
Y
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DS
P
QA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YI
D
A
RDRD
M
V
S
V
V
HDLQKAIAEK
V
Q
LK
P
G
TSVA
F
S
G
--
-Q
FE
LL
E
RANHKLK
L
M
VP
M
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAI
E
AE
PSLNNPQTFSE
QKLD
EA
LYH
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
GAGS
E
VMSR
I
A
A
PM
I
GGM
IT
A
P
LL
S
L
F
II
P
AA
Y
K
L
M
WLHRHRVRK
fig|585057.4.peg.586
Escherichia coli IAI39
MIEWIIRR
S
VA
NRF
L
VLMG
A
L
F
L
S
I
W
G
TWT
I
IN
T
PV
D
AL
P
D
L
SD
V
Q
V
I
I
K
T
S
YPG
Q
A
P
Q
I
V
E
N
Q
VT
Y
PLT
TT
M
LS
V
P
G
AK
T
VRG
F
S
QF-
G
DSY
VYV
I
FE
D
GT
D
P
Y
W
A
RS
R
V
L
EY
L
N
Q
V
QGK
LP
V-----
GV
SAELGPDAT
GVG
W
I
YEY
A
LV
D
RSGKHDLA
D
L
R
S
L
Q
DWF
L
KYE
L
K
TIP
D
V
A
E
V
ASV
G
GVVKEY
QV
V
I
DP
QR
L
A
QYG
I
SLAE
V
KS
A
L
DAS
N
QEAGG
SSI
--
-
-
--ELAEAEYM
V
R
A
SGY
LQT
L
D
D
F
NH
I
V
L
KASE
N
G
VP
V
Y
L
R
DVA
K
V
Q
V
G
P
E
MRRGI
A
EL
NG
E
G
E
V
A
G
GV
V
I
L
RS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSS
L
P
E
GV
E
IVTT
YD
RS
QL
I
DR
A
I
D
N
LSGK
L
L
E
EF
I
V
V
A
V
V
C
A
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
I
V
M
H
F
Q
G
L
N
A
N
I
MSL
G
G
I
A
I
A
V
G
A
M
VD
A
AIV
MI
EN
AH
K
R
L
E
E
WQHQHPDATL
D
NKT
R
WQ
V
IT
D
ASV
EVG
P
AL
FISLLI
I
T
LS
FIP
I
F
T
LE
G
QE
G
R
LFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------L
N
RF
L
IRV---
----
Y
HPLLL
KVL
HWPKTT
L
L
V
A
A
L
SVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TD
K
--
LIMSVPE
V
A
R
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QD
QW
R
PG--MTMD
K
II
E
EL
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LST
G
IK
S
PIGIK
V
SGTVLADI
D
T
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
LE
GGRYIN
V
E
IN
RE
KA
A
R
Y
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DS
P
QA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YI
D
A
RDRD
M
V
S
V
V
HDLQKAIAEK
V
Q
LK
P
G
TSVA
F
S
G
--
-Q
FE
LL
E
RANHKLK
L
M
VP
M
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAI
E
AE
PSLNNPQTFSE
QKLD
EA
LYH
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
GAGS
E
VMSR
I
A
A
PM
I
GGM
IT
A
P
LL
S
L
F
II
P
AA
Y
K
L
M
WLHRHRVRK
fig|585057.6.peg.584
Escherichia coli IAI39
MIEWIIRR
S
VA
NRF
L
VLMG
A
L
F
L
S
I
W
G
TWT
I
IN
T
PV
D
AL
P
D
L
SD
V
Q
V
I
I
K
T
S
YPG
Q
A
P
Q
I
V
E
N
Q
VT
Y
PLT
TT
M
LS
V
P
G
AK
T
VRG
F
S
QF-
G
DSY
VYV
I
FE
D
GT
D
P
Y
W
A
RS
R
V
L
EY
L
N
Q
V
QGK
LP
V-----
GV
SAELGPDAT
GVG
W
I
YEY
A
LV
D
RSGKHDLA
D
L
R
S
L
Q
DWF
L
KYE
L
K
TIP
D
V
A
E
V
ASV
G
GVVKEY
QV
V
I
DP
QR
L
A
QYG
I
SLAE
V
KS
A
L
DAS
N
QEAGG
SSI
--
-
-
--ELAEAEYM
V
R
A
SGY
LQT
L
D
D
F
NH
I
V
L
KASE
N
G
VP
V
Y
L
R
DVA
K
V
Q
V
G
P
E
MRRGI
A
EL
NG
E
G
E
V
A
G
GV
V
I
L
RS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSS
L
P
E
GV
E
IVTT
YD
RS
QL
I
DR
A
I
D
N
LSGK
L
L
E
EF
I
V
V
A
V
V
C
A
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
I
V
M
H
F
Q
G
L
N
A
N
I
MSL
G
G
I
A
I
A
V
G
A
M
VD
A
AIV
MI
EN
AH
K
R
L
E
E
WQHQHPDATL
D
NKT
R
WQ
V
IT
D
ASV
EVG
P
AL
FISLLI
I
T
LS
FIP
I
F
T
LE
G
QE
G
R
LFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------L
N
RF
L
IRV---
----
Y
HPLLL
KVL
HWPKTT
L
L
V
A
A
L
SVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TD
K
--
LIMSVPE
V
A
R
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QD
QW
R
PG--MTMD
K
II
E
EL
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LST
G
IK
S
PIGIK
V
SGTVLADI
D
T
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
LE
GGRYIN
V
E
IN
RE
KA
A
R
Y
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DS
P
QA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YI
D
A
RDRD
M
V
S
V
V
HDLQKAIAEK
V
Q
LK
P
G
TSVA
F
S
G
--
-Q
FE
LL
E
RANHKLK
L
M
VP
M
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAI
E
AE
PSLNNPQTFSE
QKLD
EA
LYH
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
GAGS
E
VMSR
I
A
A
PM
I
GGM
IT
A
P
LL
S
L
F
II
P
AA
Y
K
L
M
WLHRHRVRK
fig|753642.3.peg.1083
Escherichia coli NC101
MIEWIIRR
S
VA
NRF
L
VLMG
A
L
F
L
S
I
W
G
TWT
I
IN
T
PV
D
AL
P
D
L
SD
V
Q
V
I
I
K
T
S
YPG
Q
V
P
Q
I
V
E
N
Q
VT
Y
PLT
TT
M
LS
V
P
G
AK
T
VRG
F
S
QF-
G
DSY
VYV
I
FE
D
GT
D
P
Y
W
A
RS
R
V
L
EY
L
N
Q
V
QGK
LP
A-----
GV
SAELGPDAT
GVG
W
I
YEY
A
LV
D
RSGKHDLA
D
L
R
S
L
Q
DWF
L
KYE
L
K
TIP
D
V
A
E
V
ASV
G
GVVKEY
QV
V
I
DP
QR
L
A
QYG
I
SLAE
V
KS
A
L
DAS
N
QEAGG
SSI
--
-
-
--ELAEAEYM
V
R
A
SGY
LQT
L
D
D
F
NH
I
V
L
KASE
N
G
VP
V
Y
L
R
DVA
K
V
Q
V
G
P
E
MRRGI
A
EL
NG
E
G
E
V
A
G
GV
V
I
L
RS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSS
L
P
E
GV
E
IVTT
YD
RS
QL
I
DR
A
I
D
N
LSGK
L
L
E
EF
I
V
V
A
V
V
C
A
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
I
V
M
H
F
Q
G
L
N
A
N
I
MSL
G
G
I
A
I
A
V
G
A
M
VD
A
AIV
MI
EN
AH
K
R
L
E
E
WQHQHPDATL
D
NKT
R
WQ
V
IT
D
ASV
EVG
P
AL
FISLLI
I
T
LS
FIP
I
F
T
LE
G
QE
G
R
LFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------L
N
RF
L
IRV---
----
Y
HPLLL
KVL
HWPKTT
L
L
V
A
A
L
SVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TD
K
--
LIMSVPE
V
A
R
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QD
QW
R
PG--MTMD
K
II
E
EL
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LST
G
IK
S
PIGIK
V
SGTVLADI
D
T
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
LE
GGRYIN
V
E
IN
RE
KA
A
R
Y
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DS
P
QA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YI
D
A
RDRD
M
V
S
V
V
HDLQKAIAEK
V
Q
LK
P
G
TSVA
F
S
G
--
-Q
FE
LL
E
RANHKLK
L
M
VP
M
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAI
E
AE
PSLNNPQTFSE
QKLD
EA
LYH
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
GAGS
E
VMSR
I
A
A
PM
I
GGM
IT
A
P
LL
S
L
F
II
P
AA
Y
K
L
M
WLHRHRVRK
fig|199310.1.peg.636
Escherichia coli CFT073
MIEWIIRR
S
VA
NRF
L
VLMG
A
L
F
L
S
I
W
G
TWT
I
IN
T
PV
D
AL
P
D
L
SD
V
Q
V
I
I
K
T
S
YPG
Q
A
P
Q
I
V
E
N
Q
VT
Y
PLT
TT
M
LS
V
P
G
AK
T
VRG
F
S
QF-
G
DSY
VYV
I
FE
D
GT
D
P
Y
W
A
RS
R
V
L
EY
L
N
Q
V
QGK
LP
A-----
GV
SAELGPDAT
GVG
W
I
YEY
A
LV
D
RSGKHDLA
D
L
R
S
L
Q
DWF
L
KYE
L
K
TIP
D
V
A
E
V
ASV
G
GVVKEY
QV
V
I
DP
QR
L
A
QYG
I
SLAE
V
KS
A
L
DAS
N
QEAGG
SSI
--
-
-
--ELAEAEYM
V
R
A
SGY
LQT
L
D
D
F
NH
I
V
L
KASE
N
G
VP
V
Y
L
R
DVA
K
V
Q
V
G
P
E
MRRGI
A
EL
NG
E
G
E
V
A
G
GV
V
I
L
RS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSS
L
P
E
GV
E
IVTT
YD
RS
QL
I
DR
A
I
D
N
LSGK
L
L
E
EF
I
V
V
A
V
V
C
A
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
I
V
M
H
F
Q
G
L
N
A
N
I
MSL
G
G
I
A
I
A
V
G
A
M
VD
A
AIV
MI
EN
AH
K
R
L
E
E
WQHQHPDATL
D
NKT
R
WQ
V
IT
D
ASV
EVG
P
AL
FISLLI
I
T
LS
FIP
I
F
T
LE
G
QE
G
R
LFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------L
N
RF
L
IRV---
----
Y
HPLLL
KVL
HWPKTT
L
L
V
A
A
L
SVLTVLW
P
XNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TD
K
--
LIMSVPE
V
A
R
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QD
QW
R
PG--MTMD
K
II
E
EL
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LST
G
IK
S
PIGIK
V
SGTVLADI
D
T
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
LE
GGRYIN
V
E
IN
RE
KA
A
R
Y
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DS
P
QA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YI
D
A
RDRD
M
V
S
V
V
HDLQKAIAEK
V
Q
LK
P
G
TSVA
F
S
G
--
-Q
FE
LL
E
RANHKLK
L
M
VP
M
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAI
E
AE
PSLNNPQTFSE
QKLD
EA
LYH
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
GAGS
E
VMSR
I
A
A
PM
I
GGM
IT
A
P
LL
S
L
F
II
P
AA
Y
K
L
M
WLHRHRVRK
fig|199310.4.peg.626
Escherichia coli CFT073
MIEWIIRR
S
VA
NRF
L
VLMG
A
L
F
L
S
I
W
G
TWT
I
IN
T
PV
D
AL
P
D
L
SD
V
Q
V
I
I
K
T
S
YPG
Q
A
P
Q
I
V
E
N
Q
VT
Y
PLT
TT
M
LS
V
P
G
AK
T
VRG
F
S
QF-
G
DSY
VYV
I
FE
D
GT
D
P
Y
W
A
RS
R
V
L
EY
L
N
Q
V
QGK
LP
A-----
GV
SAELGPDAT
GVG
W
I
YEY
A
LV
D
RSGKHDLA
D
L
R
S
L
Q
DWF
L
KYE
L
K
TIP
D
V
A
E
V
ASV
G
GVVKEY
QV
V
I
DP
QR
L
A
QYG
I
SLAE
V
KS
A
L
DAS
N
QEAGG
SSI
--
-
-
--ELAEAEYM
V
R
A
SGY
LQT
L
D
D
F
NH
I
V
L
KASE
N
G
VP
V
Y
L
R
DVA
K
V
Q
V
G
P
E
MRRGI
A
EL
NG
E
G
E
V
A
G
GV
V
I
L
RS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSS
L
P
E
GV
E
IVTT
YD
RS
QL
I
DR
A
I
D
N
LSGK
L
L
E
EF
I
V
V
A
V
V
C
A
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
I
V
M
H
F
Q
G
L
N
A
N
I
MSL
G
G
I
A
I
A
V
G
A
M
VD
A
AIV
MI
EN
AH
K
R
L
E
E
WQHQHPDATL
D
NKT
R
WQ
V
IT
D
ASV
EVG
P
AL
FISLLI
I
T
LS
FIP
I
F
T
LE
G
QE
G
R
LFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------L
N
RF
L
IRV---
----
Y
HPLLL
KVL
HWPKTT
L
L
V
A
A
L
SVLTVLW
P
XNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TD
K
--
LIMSVPE
V
A
R
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QD
QW
R
PG--MTMD
K
II
E
EL
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LST
G
IK
S
PIGIK
V
SGTVLADI
D
T
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
LE
GGRYIN
V
E
IN
RE
KA
A
R
Y
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DS
P
QA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YI
D
A
RDRD
M
V
S
V
V
HDLQKAIAEK
V
Q
LK
P
G
TSVA
F
S
G
--
-Q
FE
LL
E
RANHKLK
L
M
VP
M
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAI
E
AE
PSLNNPQTFSE
QKLD
EA
LYH
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
GAGS
E
VMSR
I
A
A
PM
I
GGM
IT
A
P
LL
S
L
F
II
P
AA
Y
K
L
M
WLHRHRVRK
fig|714962.3.peg.600
Escherichia coli IHE3034
MIEWIIRR
S
VA
NRF
L
VLMG
A
L
F
L
S
I
W
G
TWT
I
IN
T
PV
D
AL
P
D
L
SD
V
Q
V
I
I
K
T
S
YPG
Q
A
P
Q
I
V
E
N
Q
VT
Y
PLT
TT
M
LS
V
P
G
AK
T
VRG
F
S
QF-
G
DSY
VYV
I
FE
D
GT
D
P
Y
W
A
RS
R
V
L
EY
L
N
Q
V
QGK
LP
A-----
GV
SAELGPDAT
GVG
W
I
YEY
A
LV
D
RSGKHDLA
D
L
R
S
L
Q
DWF
L
KYE
L
K
TIP
D
V
A
E
V
ASV
G
GVVKEY
QV
V
I
DP
QR
L
A
QYG
I
SLAE
V
KS
A
L
DAS
N
QEAGG
SSI
--
-
-
--ELAEAEYM
V
R
A
SGY
LQT
L
D
D
F
NH
I
V
L
KASE
N
G
VP
V
Y
L
R
DVA
K
V
Q
V
G
P
E
MRRGI
A
EL
NG
E
G
E
V
A
G
GV
V
I
L
RS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSS
L
P
E
GV
E
IVTT
YD
RS
QL
I
DR
A
I
D
N
LSGK
L
L
E
EF
I
V
V
A
V
V
C
A
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
I
V
M
H
F
Q
G
L
N
A
N
I
MSL
G
G
I
A
I
A
V
G
A
M
VD
A
AIV
MI
EN
AH
K
R
L
E
E
WQHQHPDATL
D
NKT
R
WQ
V
IT
D
ASV
EVG
P
AL
FISLLI
I
T
LS
FIP
I
F
T
LE
G
QE
G
R
LFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------L
N
RF
L
IRV---
----
Y
HPLLL
KVL
HWPKTT
L
L
V
A
A
L
SVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TD
K
--
LIMSVPE
V
A
R
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QD
QW
R
PG--MTMD
K
II
E
EL
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LST
G
IK
S
PIGIK
V
SGTVLADI
D
T
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
LE
GGRYIN
V
E
IN
RE
KA
A
R
Y
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DS
P
QA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YI
D
A
RDRD
M
V
S
V
V
HDLQKAIAEK
V
Q
LK
P
G
TSVA
F
S
G
--
-Q
FE
LL
E
RANHKLK
L
M
VP
M
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
AMGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAI
E
AE
PSLNNPQTFSE
QKLD
EA
LYH
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
GAGS
E
VMSR
I
A
A
PM
I
GGM
IT
A
P
LL
S
L
F
II
P
AA
Y
K
L
M
WLHRHRVRK
fig|749547.3.peg.3540
Escherichia coli MS 187-1
MIEWIIRR
S
VA
NRF
L
VLMG
A
L
F
L
S
I
W
G
TWT
I
IN
T
PV
D
AL
P
D
L
SD
V
Q
V
I
I
K
T
S
YPG
Q
A
P
Q
I
V
E
N
Q
VT
Y
PLT
TT
M
LS
V
P
G
AK
T
VRG
F
S
QF-
G
DSY
VYV
I
FE
D
GT
D
P
Y
W
A
RS
R
V
L
EY
L
N
Q
V
QGK
LP
A-----
GV
SAELGPDAT
GVG
W
I
YEY
A
LV
D
RSGKHDLA
D
L
R
S
L
Q
DWF
L
KYE
L
K
TIP
D
V
A
E
V
ASV
G
GVVKEY
QV
V
I
DP
QR
L
A
QYG
I
SLAE
V
KS
A
L
DAS
N
QEAGG
SSI
--
-
-
--ELAEAEYM
V
R
A
SGY
LQT
L
D
D
F
NH
I
V
L
KASE
N
G
VP
V
Y
L
R
DVA
K
V
Q
I
G
P
E
MRRGI
A
EL
NG
E
G
E
V
A
G
GV
V
I
L
RS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSS
L
P
E
GV
E
IVTT
YD
RS
QL
I
DR
A
I
D
N
LSGK
L
L
E
EF
I
V
V
A
V
V
C
A
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
I
V
M
H
F
Q
G
L
N
A
N
I
MSL
G
G
I
A
I
A
V
G
A
M
VD
A
AIV
MI
EN
AH
K
R
L
E
E
WQHQHPDATL
D
NKT
R
WQ
V
IT
D
ASV
EVG
P
AL
FISLLI
I
T
LS
FIP
I
F
T
LE
G
QE
G
R
LFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------L
N
RF
L
IRV---
----
Y
HPLLL
KVL
HWPKTT
L
L
V
A
A
L
SVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TD
K
--
LIMSVPE
V
A
R
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
SG--MTMD
K
II
E
EL
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LST
G
IK
S
PIGIK
V
SGTVLADI
D
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
LE
GGRYIN
V
E
IN
RE
KA
A
R
Y
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DS
P
QA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DIKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YI
D
A
RDRD
M
V
S
V
V
HDLQKAIAEK
V
Q
LK
P
G
TSVA
F
S
G
--
-Q
FE
LL
E
RANHKLK
L
M
VP
M
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAI
E
AV
PSLNNPQTFSE
QKLD
EA
LYH
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
GAGS
E
VMSR
I
A
A
PM
I
GGM
IT
A
P
LL
S
L
F
II
P
AA
Y
K
L
M
WLHRHRVRK
fig|869729.3.peg.3132
Escherichia coli UM146
MIEWIIRR
S
VA
NRF
L
VLMG
A
L
F
L
S
I
W
G
TWT
I
IN
T
PV
D
AL
P
D
L
SD
V
Q
V
I
I
K
T
S
YPG
Q
A
P
Q
I
V
E
N
Q
VT
Y
PLT
TT
M
LS
V
P
G
AK
T
VRG
F
S
QF-
G
DSY
VYV
I
FE
D
GT
D
P
Y
W
A
RS
R
V
L
EY
L
N
Q
V
QGK
LP
A-----
GV
SAELGPDAT
GVG
W
I
YEY
A
LV
D
RSGKHDLA
D
L
R
S
L
Q
DWF
L
KYE
L
K
TIP
D
V
A
E
V
ASV
G
GVVKEY
QV
V
I
DP
QR
L
A
QYG
I
SLAE
V
KS
A
L
DAS
N
QEAGG
SSI
--
-
-
--ELAEAEYM
V
R
A
SGY
LQT
L
D
D
F
NH
I
V
L
KASE
N
G
VP
V
Y
L
R
DVA
K
V
Q
V
G
P
E
MRRGI
A
EL
NG
E
G
E
V
A
G
GV
V
I
L
RS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSS
L
P
E
GV
E
IVTT
YD
RS
QL
I
DR
A
I
D
N
LSGK
L
L
E
EF
I
V
V
A
V
V
C
A
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
I
V
M
H
F
Q
G
L
N
A
N
I
MSL
G
G
I
A
I
A
V
G
A
M
VD
A
AIV
MI
EN
AH
K
R
L
E
E
WQHQHPDATL
D
NKT
R
WQ
V
IT
D
ASV
EVG
P
AL
FISLLI
I
T
LS
FIP
I
F
T
LE
G
QE
G
R
LFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------L
N
RF
L
IRV---
----
Y
HPLLL
KVL
HWPKTT
L
L
V
A
A
L
SVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TD
K
--
LIMSVPE
V
A
R
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QD
QW
R
PG--MTMD
K
II
E
EL
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LST
G
IK
S
PIGIK
V
SGTVLADI
D
T
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
LE
GGRYIN
V
E
IN
RE
KA
A
R
Y
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DS
P
QA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YI
D
A
RDRD
M
V
S
V
V
HDLQKAIAEK
V
Q
LK
P
G
TSVA
F
S
G
--
-Q
FE
LL
E
RANHKLK
L
M
VP
M
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
AMGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAI
E
AE
PSLNNPQTFSE
QKLD
EA
LYH
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
GAGS
E
VMSR
I
A
A
PM
I
GGM
IT
A
P
LL
S
L
F
II
P
AA
Y
K
L
M
WLHRHRVRK
fig|364106.7.peg.680
Escherichia coli UTI89
MIEWIIRR
S
VA
NRF
L
VLMG
A
L
F
L
S
I
W
G
TWT
I
IN
T
PV
D
AL
P
D
L
SD
V
Q
V
I
I
K
T
S
YPG
Q
A
P
Q
I
V
E
N
Q
VT
Y
PLT
TT
M
LS
V
P
G
AK
T
VRG
F
S
QF-
G
DSY
VYV
I
FE
D
GT
D
P
Y
W
A
RS
R
V
L
EY
L
N
Q
V
QGK
LP
A-----
GV
SAELGPDAT
GVG
W
I
YEY
A
LV
D
RSGKHDLA
D
L
R
S
L
Q
DWF
L
KYE
L
K
TIP
D
V
A
E
V
ASV
G
GVVKEY
QV
V
I
DP
QR
L
A
QYG
I
SLAE
V
KS
A
L
DAS
N
QEAGG
SSI
--
-
-
--ELAEAEYM
V
R
A
SGY
LQT
L
D
D
F
NH
I
V
L
KASE
N
G
VP
V
Y
L
R
DVA
K
V
Q
V
G
P
E
MRRGI
A
EL
NG
E
G
E
V
A
G
GV
V
I
L
RS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSS
L
P
E
GV
E
IVTT
YD
RS
QL
I
DR
A
I
D
N
LSGK
L
L
E
EF
I
V
V
A
V
V
C
A
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
I
V
M
H
F
Q
G
L
N
A
N
I
MSL
G
G
I
A
I
A
V
G
A
M
VD
A
AIV
MI
EN
AH
K
R
L
E
E
WQHQHPDATL
D
NKT
R
WQ
V
IT
D
ASV
EVG
P
AL
FISLLI
I
T
LS
FIP
I
F
T
LE
G
QE
G
R
LFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------L
N
RF
L
IRV---
----
Y
HPLLL
KVL
HWPKTT
L
L
V
A
A
L
SVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TD
K
--
LIMSVPE
V
A
R
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QD
QW
R
PG--MTMD
K
II
E
EL
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LST
G
IK
S
PIGIK
V
SGTVLADI
D
T
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
LE
GGRYIN
V
E
IN
RE
KA
A
R
Y
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DS
P
QA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YI
D
A
RDRD
M
V
S
V
V
HDLQKAIAEK
V
Q
LK
P
G
TSVA
F
S
G
--
-Q
FE
LL
E
RANHKLK
L
M
VP
M
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
AMGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAI
E
AE
PSLNNPQTFSE
QKLD
EA
LYH
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
GAGS
E
VMSR
I
A
A
PM
I
GGM
IT
A
P
LL
S
L
F
II
P
AA
Y
K
L
M
WLHRHRVRK
fig|364106.8.peg.678
Escherichia coli UTI89
MIEWIIRR
S
VA
NRF
L
VLMG
A
L
F
L
S
I
W
G
TWT
I
IN
T
PV
D
AL
P
D
L
SD
V
Q
V
I
I
K
T
S
YPG
Q
A
P
Q
I
V
E
N
Q
VT
Y
PLT
TT
M
LS
V
P
G
AK
T
VRG
F
S
QF-
G
DSY
VYV
I
FE
D
GT
D
P
Y
W
A
RS
R
V
L
EY
L
N
Q
V
QGK
LP
A-----
GV
SAELGPDAT
GVG
W
I
YEY
A
LV
D
RSGKHDLA
D
L
R
S
L
Q
DWF
L
KYE
L
K
TIP
D
V
A
E
V
ASV
G
GVVKEY
QV
V
I
DP
QR
L
A
QYG
I
SLAE
V
KS
A
L
DAS
N
QEAGG
SSI
--
-
-
--ELAEAEYM
V
R
A
SGY
LQT
L
D
D
F
NH
I
V
L
KASE
N
G
VP
V
Y
L
R
DVA
K
V
Q
V
G
P
E
MRRGI
A
EL
NG
E
G
E
V
A
G
GV
V
I
L
RS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSS
L
P
E
GV
E
IVTT
YD
RS
QL
I
DR
A
I
D
N
LSGK
L
L
E
EF
I
V
V
A
V
V
C
A
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
I
V
M
H
F
Q
G
L
N
A
N
I
MSL
G
G
I
A
I
A
V
G
A
M
VD
A
AIV
MI
EN
AH
K
R
L
E
E
WQHQHPDATL
D
NKT
R
WQ
V
IT
D
ASV
EVG
P
AL
FISLLI
I
T
LS
FIP
I
F
T
LE
G
QE
G
R
LFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------L
N
RF
L
IRV---
----
Y
HPLLL
KVL
HWPKTT
L
L
V
A
A
L
SVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TD
K
--
LIMSVPE
V
A
R
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QD
QW
R
PG--MTMD
K
II
E
EL
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LST
G
IK
S
PIGIK
V
SGTVLADI
D
T
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
LE
GGRYIN
V
E
IN
RE
KA
A
R
Y
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DS
P
QA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YI
D
A
RDRD
M
V
S
V
V
HDLQKAIAEK
V
Q
LK
P
G
TSVA
F
S
G
--
-Q
FE
LL
E
RANHKLK
L
M
VP
M
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
AMGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAI
E
AE
PSLNNPQTFSE
QKLD
EA
LYH
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
GAGS
E
VMSR
I
A
A
PM
I
GGM
IT
A
P
LL
S
L
F
II
P
AA
Y
K
L
M
WLHRHRVRK
fig|656419.3.peg.850
Escherichia coli M718
MIEWIIRR
S
VA
NRF
L
VLMG
A
L
F
L
S
I
W
G
TWT
I
IN
T
PV
D
AL
P
D
L
SD
V
Q
V
I
I
K
T
S
YPG
Q
A
P
Q
I
V
E
N
Q
VT
Y
PLT
TT
M
LS
V
P
G
AK
T
VRG
F
S
QF-
G
DSY
VYV
I
FE
D
GT
D
P
Y
W
A
RS
R
V
L
EY
L
N
Q
V
QGK
LP
A-----
GV
SAELGPDAT
GVG
W
I
YEY
A
LV
D
RSGKHDLA
D
L
R
S
L
Q
DWF
L
KYE
L
K
TIP
D
V
A
E
V
ASV
G
GVVKEY
QV
V
I
DP
QR
L
A
QYG
I
SLGE
V
KN
A
L
DAS
N
QEAGG
SSI
--
-
-
--ELAEAEYM
V
R
A
SGY
LQT
L
D
D
F
NH
I
V
L
KASE
N
G
VP
V
Y
L
R
DVA
K
V
Q
V
G
P
E
MRRGI
A
EL
NG
E
G
E
V
A
G
GV
V
I
L
RS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSS
L
P
E
GV
E
IVTT
YD
RS
QL
I
DR
A
I
D
N
LSGK
L
L
E
EF
I
V
V
A
V
V
C
A
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
I
V
M
H
F
Q
G
L
N
A
N
I
MSL
G
G
I
A
I
A
V
G
A
M
VD
A
AIV
MI
EN
AH
K
R
L
E
E
WQHQHPDATL
D
NKT
R
WQ
V
IT
D
ASV
EVG
P
AL
FISLLI
I
T
LS
FIP
I
F
T
LE
G
QE
G
R
LFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------L
N
RF
L
IRV---
----
Y
HPLLL
KVL
HWPKTT
L
L
V
A
A
L
SVLTVIW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TD
K
--
LIMSVPE
V
A
R
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QD
QW
R
PG--MTMD
K
II
E
EL
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LST
G
IK
S
PIGIK
V
SGTVLADI
D
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
LE
GGRYIN
V
E
IN
RE
KA
A
R
Y
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DS
P
QA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YI
D
A
RDRD
M
V
S
V
V
HDLQKAIAEK
V
Q
LK
P
G
TSVA
F
S
G
--
-Q
FE
LL
E
RANHKLK
L
M
VP
M
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAI
E
AE
PSLNNPQTFSE
QKLD
EA
LYH
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
GAGS
E
VMSR
I
A
A
PM
I
GGM
IT
A
P
LL
S
L
F
II
P
AA
Y
K
L
M
WLHRHRVRK
fig|362663.8.peg.608
Escherichia coli 536
MIEWIIRR
S
VA
NRF
L
VLMG
A
L
F
L
S
I
W
G
TWT
I
IN
T
PV
D
AL
P
D
L
SD
V
Q
V
I
I
K
T
S
YPG
Q
A
P
Q
I
V
E
N
Q
VT
Y
PLT
TT
M
LS
V
P
G
AK
T
VRG
F
S
QF-
G
DSY
VYV
I
FE
D
GT
D
P
Y
W
A
RS
R
V
L
EY
L
N
Q
V
QGK
LP
A-----
GV
SAELGPDAT
GVG
W
I
YEY
A
LV
D
RSGKHDLA
D
L
R
S
L
Q
DWF
L
KYE
L
K
TIP
D
V
A
E
V
ASV
G
GVVKEY
QV
V
I
DP
QR
L
A
QYG
I
SLAE
V
KS
A
L
DAS
N
QEAGG
SSI
--
-
-
--ELAEAEYM
V
R
A
SGY
LQT
L
D
D
F
NH
I
V
L
KASE
N
G
VP
V
Y
L
R
DVA
K
V
Q
V
G
P
E
MRRGI
A
EL
NG
E
G
E
V
A
G
GV
V
I
L
RS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSS
L
P
E
GV
E
IVTT
YD
RS
QL
I
DR
A
I
D
N
LSGK
L
L
E
EF
I
V
V
A
V
V
C
A
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
I
V
M
H
F
Q
G
L
N
A
N
I
MSL
G
G
I
A
I
A
V
G
A
M
VD
A
AIV
MI
EN
AH
K
R
L
E
E
WQHQHPDATL
D
NKT
R
WQ
V
IT
D
ASV
EVG
P
AL
FISLLI
I
T
LS
FIP
I
F
T
LE
G
QE
G
R
LFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------L
N
RF
L
IRV---
----
Y
HPLLL
KVL
HWPKTT
L
L
V
A
A
L
SVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TD
K
--
LIMSVPE
V
A
R
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QD
QW
R
PG--MTMD
K
II
E
EL
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LST
G
IK
S
PIGIK
V
SGTVLADI
D
T
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
LE
GGRYIN
V
E
IN
RE
KA
A
R
Y
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DS
P
QA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YI
D
A
RDRD
M
V
S
V
V
HDLQKAIAEK
V
Q
LK
P
G
TSVA
F
S
G
--
-Q
FE
LL
E
RANHKLK
L
M
VP
M
T
L
M
I
I
F
V
L
L
YL
AFRR
VSE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAI
E
AE
PSLNNPQTFSE
QKLD
EA
LYH
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
GAGS
E
VMSR
I
A
A
PM
I
GGM
IT
A
P
LL
S
L
F
II
P
AA
Y
K
L
M
WLHRHRVRK
fig|362663.9.peg.609
Escherichia coli 536
MIEWIIRR
S
VA
NRF
L
VLMG
A
L
F
L
S
I
W
G
TWT
I
IN
T
PV
D
AL
P
D
L
SD
V
Q
V
I
I
K
T
S
YPG
Q
A
P
Q
I
V
E
N
Q
VT
Y
PLT
TT
M
LS
V
P
G
AK
T
VRG
F
S
QF-
G
DSY
VYV
I
FE
D
GT
D
P
Y
W
A
RS
R
V
L
EY
L
N
Q
V
QGK
LP
A-----
GV
SAELGPDAT
GVG
W
I
YEY
A
LV
D
RSGKHDLA
D
L
R
S
L
Q
DWF
L
KYE
L
K
TIP
D
V
A
E
V
ASV
G
GVVKEY
QV
V
I
DP
QR
L
A
QYG
I
SLAE
V
KS
A
L
DAS
N
QEAGG
SSI
--
-
-
--ELAEAEYM
V
R
A
SGY
LQT
L
D
D
F
NH
I
V
L
KASE
N
G
VP
V
Y
L
R
DVA
K
V
Q
V
G
P
E
MRRGI
A
EL
NG
E
G
E
V
A
G
GV
V
I
L
RS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSS
L
P
E
GV
E
IVTT
YD
RS
QL
I
DR
A
I
D
N
LSGK
L
L
E
EF
I
V
V
A
V
V
C
A
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
I
V
M
H
F
Q
G
L
N
A
N
I
MSL
G
G
I
A
I
A
V
G
A
M
VD
A
AIV
MI
EN
AH
K
R
L
E
E
WQHQHPDATL
D
NKT
R
WQ
V
IT
D
ASV
EVG
P
AL
FISLLI
I
T
LS
FIP
I
F
T
LE
G
QE
G
R
LFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------L
N
RF
L
IRV---
----
Y
HPLLL
KVL
HWPKTT
L
L
V
A
A
L
SVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TD
K
--
LIMSVPE
V
A
R
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QD
QW
R
PG--MTMD
K
II
E
EL
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LST
G
IK
S
PIGIK
V
SGTVLADI
D
T
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
LE
GGRYIN
V
E
IN
RE
KA
A
R
Y
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DS
P
QA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YI
D
A
RDRD
M
V
S
V
V
HDLQKAIAEK
V
Q
LK
P
G
TSVA
F
S
G
--
-Q
FE
LL
E
RANHKLK
L
M
VP
M
T
L
M
I
I
F
V
L
L
YL
AFRR
VSE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAI
E
AE
PSLNNPQTFSE
QKLD
EA
LYH
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
GAGS
E
VMSR
I
A
A
PM
I
GGM
IT
A
P
LL
S
L
F
II
P
AA
Y
K
L
M
WLHRHRVRK
fig|340197.3.peg.2412
Escherichia coli F11
MIEWIIRR
S
VA
NRF
L
VLMG
A
L
F
L
S
I
W
G
TWT
I
IN
T
PV
D
AL
P
D
L
SD
V
Q
V
I
I
K
T
S
YPG
Q
A
P
Q
I
V
E
N
Q
VT
Y
PLT
TT
M
LS
V
P
G
AK
T
VRG
F
S
QF-
G
DSY
VYV
I
FE
D
GT
D
P
Y
W
A
RS
R
V
L
EY
L
N
Q
V
QGK
LP
A-----
GV
SAELGPDAT
GVG
W
I
YEY
A
LV
D
RSGKHDLA
D
L
R
S
L
Q
DWF
L
KYE
L
K
TIP
D
V
A
E
V
ASV
G
GVVKEY
QV
V
I
DP
QR
L
A
QYG
I
SLAE
V
KS
A
L
DAS
N
QEAGG
SSI
--
-
-
--ELAEAEYM
V
R
A
SGY
LQT
L
D
D
F
NH
I
V
L
KASE
N
G
VP
V
Y
L
R
DVA
K
V
Q
V
G
P
E
MRRGI
A
EL
NG
E
G
E
V
A
G
GV
V
I
L
RS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSS
L
P
E
GV
E
IVTT
YD
RS
QL
I
DR
A
I
D
N
LSGK
L
L
E
EF
I
V
V
A
V
V
C
A
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
I
V
M
H
F
Q
G
L
N
A
N
I
MSL
G
G
I
A
I
A
V
G
A
M
VD
A
AIV
MI
EN
AH
K
R
L
E
E
WQHQHPDATL
D
NKT
R
WQ
V
IT
D
ASV
EVG
P
AL
FISLLI
I
T
LS
FIP
I
F
T
LE
G
QE
G
R
LFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------L
N
RF
L
IRV---
----
Y
HPLLL
KVL
HWPKTT
L
L
V
A
A
L
SVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TD
K
--
LIMSVPE
V
A
R
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QD
QW
R
PG--MTMD
K
II
E
EL
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LST
G
IK
S
PIGIK
V
SGTVLADI
D
T
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
LE
GGRYIN
V
E
IN
RE
KA
A
R
Y
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DS
P
QA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YI
D
A
RDRD
M
V
S
V
V
HDLQKAIAEK
V
Q
LK
P
G
TSVA
F
S
G
--
-Q
FE
LL
E
RANHKLK
L
M
VP
M
T
L
M
I
I
F
V
L
L
YL
AFRR
VSE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAI
E
AE
PSLNNPQTFSE
QKLD
EA
LYH
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
GAGS
E
VMSR
I
A
A
PM
I
GGM
IT
A
P
LL
S
L
F
II
P
AA
Y
K
L
M
WLHRHRVRK
fig|340197.5.peg.2530
Escherichia coli F11
MIEWIIRR
S
VA
NRF
L
VLMG
A
L
F
L
S
I
W
G
TWT
I
IN
T
PV
D
AL
P
D
L
SD
V
Q
V
I
I
K
T
S
YPG
Q
A
P
Q
I
V
E
N
Q
VT
Y
PLT
TT
M
LS
V
P
G
AK
T
VRG
F
S
QF-
G
DSY
VYV
I
FE
D
GT
D
P
Y
W
A
RS
R
V
L
EY
L
N
Q
V
QGK
LP
A-----
GV
SAELGPDAT
GVG
W
I
YEY
A
LV
D
RSGKHDLA
D
L
R
S
L
Q
DWF
L
KYE
L
K
TIP
D
V
A
E
V
ASV
G
GVVKEY
QV
V
I
DP
QR
L
A
QYG
I
SLAE
V
KS
A
L
DAS
N
QEAGG
SSI
--
-
-
--ELAEAEYM
V
R
A
SGY
LQT
L
D
D
F
NH
I
V
L
KASE
N
G
VP
V
Y
L
R
DVA
K
V
Q
V
G
P
E
MRRGI
A
EL
NG
E
G
E
V
A
G
GV
V
I
L
RS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSS
L
P
E
GV
E
IVTT
YD
RS
QL
I
DR
A
I
D
N
LSGK
L
L
E
EF
I
V
V
A
V
V
C
A
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
I
V
M
H
F
Q
G
L
N
A
N
I
MSL
G
G
I
A
I
A
V
G
A
M
VD
A
AIV
MI
EN
AH
K
R
L
E
E
WQHQHPDATL
D
NKT
R
WQ
V
IT
D
ASV
EVG
P
AL
FISLLI
I
T
LS
FIP
I
F
T
LE
G
QE
G
R
LFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------L
N
RF
L
IRV---
----
Y
HPLLL
KVL
HWPKTT
L
L
V
A
A
L
SVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TD
K
--
LIMSVPE
V
A
R
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QD
QW
R
PG--MTMD
K
II
E
EL
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LST
G
IK
S
PIGIK
V
SGTVLADI
D
T
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
LE
GGRYIN
V
E
IN
RE
KA
A
R
Y
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DS
P
QA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YI
D
A
RDRD
M
V
S
V
V
HDLQKAIAEK
V
Q
LK
P
G
TSVA
F
S
G
--
-Q
FE
LL
E
RANHKLK
L
M
VP
M
T
L
M
I
I
F
V
L
L
YL
AFRR
VSE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAI
E
AE
PSLNNPQTFSE
QKLD
EA
LYH
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
GAGS
E
VMSR
I
A
A
PM
I
GGM
IT
A
P
LL
S
L
F
II
P
AA
Y
K
L
M
WLHRHRVRK
fig|749550.3.peg.4627
Escherichia coli MS 200-1
MIEWIIRR
S
VA
NRF
L
VLMG
A
L
F
L
S
I
W
G
TWT
I
IN
T
PV
D
AL
P
D
L
SD
V
Q
V
I
I
K
T
S
YPG
Q
A
P
Q
I
V
E
N
Q
VT
Y
PLT
TT
M
LS
V
P
G
AK
T
VRG
F
S
QF-
G
DSY
VYV
I
FE
D
GT
D
P
Y
W
A
RS
R
V
L
EY
L
N
Q
V
QGK
LP
A-----
GV
SAELGPDAT
GVG
W
I
YEY
A
LV
D
RSGKHDLA
D
L
R
S
L
Q
DWF
L
KYE
L
K
TIP
D
V
A
E
V
ASV
G
GVVKEY
QV
V
I
DP
QR
L
A
QYG
I
SLAE
V
KS
A
L
DAS
N
QEAGG
SSI
--
-
-
--ELAEAEYM
V
R
A
SGY
LQT
L
D
D
F
NH
I
V
L
KASE
N
G
VP
V
Y
L
R
DVA
K
V
Q
V
G
P
E
MRRGI
A
EL
NG
E
G
E
V
A
G
GV
V
I
L
RS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSS
L
P
E
GV
E
IVTT
YD
RS
QL
I
DR
A
I
D
N
LSGK
L
L
E
EF
I
V
V
A
V
V
C
A
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
I
V
M
H
F
Q
G
L
N
A
N
I
MSL
G
G
I
A
I
A
V
G
A
M
VD
A
AIV
MI
EN
AH
K
R
L
E
E
WQHQHPDATL
D
NKT
R
WQ
V
IT
D
ASV
EVG
P
AL
FISLLI
I
T
LS
FIP
I
F
T
LE
G
QE
G
R
LFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------L
N
RF
L
IRV---
----
Y
HPLLL
KVL
HWPKTT
L
L
V
A
A
L
SVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TD
K
--
LIMSVPE
V
A
R
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QD
QW
R
PG--MTMD
K
II
E
EL
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LST
G
IK
S
PIGIK
V
SGTVLADI
D
T
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
LE
GGRYIN
V
E
IN
RE
KA
A
R
Y
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DS
P
QA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YI
D
A
RDRD
M
V
S
V
V
HDLQKAIAEK
V
Q
LK
P
G
TSVA
F
S
G
--
-Q
FE
LL
E
RANHKLK
L
M
VP
M
T
L
M
I
I
F
V
L
L
YL
AFRR
VSE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAI
E
AE
PSLNNPQTFSE
QKLD
EA
LYH
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
GAGS
E
VMSR
I
A
A
PM
I
GGM
IT
A
P
LL
S
L
F
II
P
AA
Y
K
L
M
WLHRHRVRK
fig|670897.3.peg.172
Escherichia coli 2362-75
MIEWIIRR
S
VA
NRF
L
VLMG
A
L
F
L
S
I
W
G
TWT
I
IN
T
PV
D
AL
P
D
L
SD
V
Q
V
I
I
K
T
S
YPG
Q
A
P
Q
I
V
E
N
Q
VT
Y
PLT
TT
M
LS
V
P
G
AK
T
VRG
F
S
QF-
G
DSY
VYV
I
FE
D
GT
D
P
Y
W
A
RS
R
V
L
EY
L
N
Q
V
QGK
LP
A-----
GV
SAELGPDAT
GVG
W
I
YEY
A
LV
D
RSGKHDLA
D
L
R
S
L
Q
DWF
L
KYE
L
K
TIP
D
V
A
E
V
ASV
G
GVVKEY
QV
V
I
DP
QR
L
A
QYG
I
SLAE
V
KS
A
L
DAS
N
QEAGG
SSI
--
-
-
--ELAEAEYM
V
R
A
SGY
LQT
L
D
D
F
NH
I
V
L
KASE
N
G
VP
V
Y
L
R
DVA
K
V
Q
V
G
P
E
MRRGI
A
EL
NG
E
G
E
V
A
G
GV
V
I
L
RS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSS
L
P
E
GV
E
IVTT
YD
RS
QL
I
DR
A
I
D
N
LSGK
L
L
E
EF
I
V
V
A
V
V
C
A
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
I
V
M
H
F
Q
G
L
N
A
N
I
MSL
G
G
I
A
I
A
V
G
A
M
VD
A
AIV
MI
EN
AH
K
R
L
E
E
WQHQHPDATL
D
NKT
R
WQ
V
IT
D
ASV
EVG
P
AL
FISLLI
I
T
LS
FIP
I
F
T
LE
G
QE
G
R
LFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------L
N
RF
L
IRV---
----
Y
HPLLL
KVL
HWPKTT
L
L
V
A
A
L
SVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TD
K
--
LIMSVPE
V
A
R
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QD
QW
R
PG--MTMD
K
II
E
EL
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LST
G
IK
S
PIGIK
V
SGTVLADI
D
T
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
LE
GGRYIN
V
E
IN
RE
KA
A
R
Y
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DS
P
QA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVFT
G
P
SM
L
KTE
N
AR
P
TSW
I
YI
D
A
RDRD
M
V
S
V
V
HDLQKAIAEK
V
Q
LK
P
G
TSVA
F
S
G
--
-Q
FE
LL
E
RANHKLK
L
M
VP
M
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAI
E
AE
PSLNNPQTFSE
QKLD
EA
LYH
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
GAGS
E
VMSR
I
A
A
PM
I
GGM
IT
A
P
LL
S
L
F
II
P
AA
Y
K
L
M
WLHRHRVRK
fig|216593.1.peg.3046
Escherichia coli E2348/69
MIEWIIRR
S
VA
NRF
L
VLMG
A
L
F
L
S
I
W
G
TWT
I
IN
T
PV
D
AL
P
D
L
SD
V
Q
V
I
I
K
T
S
YPG
Q
A
P
Q
I
V
E
N
Q
VT
Y
PLT
TT
M
LS
V
P
G
AK
T
VRG
F
S
QF-
G
DSY
VYV
I
FE
D
GT
D
P
Y
W
A
RS
R
V
L
EY
L
N
Q
V
QGK
LP
A-----
GV
SAELGPDAT
GVG
W
I
YEY
A
LV
D
RSGKHDLA
D
L
R
S
L
Q
DWF
L
KYE
L
K
TIP
D
V
A
E
V
ASV
G
GVVKEY
QV
V
I
DP
QR
L
A
QYG
I
SLAE
V
KS
A
L
DAS
N
QEAGG
SSI
--
-
-
--ELAEAEYM
V
R
A
SGY
LQT
L
D
D
F
NH
I
V
L
KASE
N
G
VP
V
Y
L
R
DVA
K
V
Q
V
G
P
E
MRRGI
A
EL
NG
E
G
E
V
A
G
GV
V
I
L
RS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSS
L
P
E
GV
E
IVTT
YD
RS
QL
I
DR
A
I
D
N
LSGK
L
L
E
EF
I
V
V
A
V
V
C
A
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
I
V
M
H
F
Q
G
L
N
A
N
I
MSL
G
G
I
A
I
A
V
G
A
M
VD
A
AIV
MI
EN
AH
K
R
L
E
E
WQHQHPDATL
D
NKT
R
WQ
V
IT
D
ASV
EVG
P
AL
FISLLI
I
T
LS
FIP
I
F
T
LE
G
QE
G
R
LFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------L
N
RF
L
IRV---
----
Y
HPLLL
KVL
HWPKTT
L
L
V
A
A
L
SVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TD
K
--
LIMSVPE
V
A
R
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QD
QW
R
PG--MTMD
K
II
E
EL
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LST
G
IK
S
PIGIK
V
SGTVLADI
D
T
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
LE
GGRYIN
V
E
IN
RE
KA
A
R
Y
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DS
P
QA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVFT
G
P
SM
L
KTE
N
AR
P
TSW
I
YI
D
A
RDRD
M
V
S
V
V
HDLQKAIAEK
V
Q
LK
P
G
TSVA
F
S
G
--
-Q
FE
LL
E
RANHKLK
L
M
VP
M
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAI
E
AE
PSLNNPQTFSE
QKLD
EA
LYH
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
GAGS
E
VMSR
I
A
A
PM
I
GGM
IT
A
P
LL
S
L
F
II
P
AA
Y
K
L
M
WLHRHRVRK
fig|574521.7.peg.511
Escherichia coli O127:H6 str. E2348/69
MIEWIIRR
S
VA
NRF
L
VLMG
A
L
F
L
S
I
W
G
TWT
I
IN
T
PV
D
AL
P
D
L
SD
V
Q
V
I
I
K
T
S
YPG
Q
A
P
Q
I
V
E
N
Q
VT
Y
PLT
TT
M
LS
V
P
G
AK
T
VRG
F
S
QF-
G
DSY
VYV
I
FE
D
GT
D
P
Y
W
A
RS
R
V
L
EY
L
N
Q
V
QGK
LP
A-----
GV
SAELGPDAT
GVG
W
I
YEY
A
LV
D
RSGKHDLA
D
L
R
S
L
Q
DWF
L
KYE
L
K
TIP
D
V
A
E
V
ASV
G
GVVKEY
QV
V
I
DP
QR
L
A
QYG
I
SLAE
V
KS
A
L
DAS
N
QEAGG
SSI
--
-
-
--ELAEAEYM
V
R
A
SGY
LQT
L
D
D
F
NH
I
V
L
KASE
N
G
VP
V
Y
L
R
DVA
K
V
Q
V
G
P
E
MRRGI
A
EL
NG
E
G
E
V
A
G
GV
V
I
L
RS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSS
L
P
E
GV
E
IVTT
YD
RS
QL
I
DR
A
I
D
N
LSGK
L
L
E
EF
I
V
V
A
V
V
C
A
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
I
V
M
H
F
Q
G
L
N
A
N
I
MSL
G
G
I
A
I
A
V
G
A
M
VD
A
AIV
MI
EN
AH
K
R
L
E
E
WQHQHPDATL
D
NKT
R
WQ
V
IT
D
ASV
EVG
P
AL
FISLLI
I
T
LS
FIP
I
F
T
LE
G
QE
G
R
LFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------L
N
RF
L
IRV---
----
Y
HPLLL
KVL
HWPKTT
L
L
V
A
A
L
SVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TD
K
--
LIMSVPE
V
A
R
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QD
QW
R
PG--MTMD
K
II
E
EL
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LST
G
IK
S
PIGIK
V
SGTVLADI
D
T
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
LE
GGRYIN
V
E
IN
RE
KA
A
R
Y
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DS
P
QA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVFT
G
P
SM
L
KTE
N
AR
P
TSW
I
YI
D
A
RDRD
M
V
S
V
V
HDLQKAIAEK
V
Q
LK
P
G
TSVA
F
S
G
--
-Q
FE
LL
E
RANHKLK
L
M
VP
M
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAI
E
AE
PSLNNPQTFSE
QKLD
EA
LYH
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
GAGS
E
VMSR
I
A
A
PM
I
GGM
IT
A
P
LL
S
L
F
II
P
AA
Y
K
L
M
WLHRHRVRK
fig|749527.3.peg.4942
Escherichia coli MS 21-1
MIEWIIRR
S
VA
NRF
L
VLMG
A
L
F
L
S
I
W
G
TWT
I
IN
T
PV
D
AL
P
D
L
SD
V
Q
V
I
I
K
T
S
YPG
Q
A
P
Q
I
V
E
N
Q
VT
Y
PLT
TT
M
LS
V
P
G
AK
T
VRG
F
S
QF-
G
DSY
VYV
I
FE
D
GT
D
P
Y
W
A
RS
R
V
L
EY
L
N
Q
V
QGK
LP
A-----
GV
SAELGPDAT
GVG
W
I
YEY
A
LV
D
RSGKHDLA
D
L
R
S
L
Q
DWF
L
KYE
L
K
TIP
D
V
A
E
V
ASV
G
GVVKEY
QV
V
I
DP
QR
L
A
QYG
I
SLAE
V
KS
A
L
DAS
N
QEAGG
SSI
--
-
-
--ELAEAEYM
V
R
A
SGY
LQT
L
D
D
F
NH
I
V
L
KASE
N
G
VP
V
Y
L
R
DVA
K
V
Q
V
G
P
E
MRRGI
A
EL
NG
E
G
E
V
A
G
GV
V
I
L
RS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSS
L
P
E
GV
E
IVTT
YD
RS
QL
I
DR
A
I
D
N
LSGK
L
L
E
EF
I
V
V
A
V
V
C
A
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
I
V
M
H
F
Q
G
L
N
A
N
I
MSL
G
G
I
A
I
A
V
G
A
M
VD
A
AIV
MI
EN
AH
K
R
L
E
E
WQHQHPDATL
D
NKT
R
WQ
V
IT
D
ASV
EVG
P
AL
FISLLI
I
T
LS
FIP
I
F
T
LE
G
QE
G
R
LFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------L
N
RF
L
IRV---
----
Y
HPLLL
KVL
HWPKTT
L
L
V
A
A
L
SVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TD
K
--
LIMSVPE
V
A
Q
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
K
LKP
QD
QW
R
PG--MTMD
K
II
E
EL
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LST
G
IK
S
PIGIK
V
SGTVLADI
D
T
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
LE
GGRYIN
V
E
IN
RE
KA
A
R
Y
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DS
P
QA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YI
D
A
RDRD
M
V
S
V
V
HDLQKAIAEK
V
Q
LK
P
G
TSVA
F
S
G
--
-Q
FE
LL
E
RANHKLK
L
M
VP
M
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAI
E
AE
PSLNNPQTFSE
QKLD
EA
LYH
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
GAGS
E
VMSR
I
A
A
PM
I
GGM
IT
A
P
LL
S
L
F
II
P
AA
Y
K
L
M
WLHRHRVRK
fig|344601.3.peg.2299
Escherichia coli B171
MIEWIIRR
S
VA
NRF
L
VLMG
A
L
F
L
S
I
W
G
TWT
I
IN
T
PV
D
AL
P
D
L
SD
V
Q
V
I
I
K
T
S
YPG
Q
A
P
Q
I
V
E
N
Q
VT
Y
PLT
TT
M
LS
V
P
G
AK
T
VRG
F
S
QF-
G
DSY
VYV
I
FE
D
GT
D
P
Y
W
A
RS
R
V
L
EY
L
N
Q
V
QGK
LP
A-----
GV
SAELGPDAT
GVG
W
I
YEY
A
LV
D
RSGKHDLA
D
L
R
S
L
Q
DWF
L
KYE
L
K
TIP
D
V
A
E
V
ASV
G
GVVKEY
QV
V
I
DP
QR
L
A
QYG
I
SLAE
V
KS
A
L
DAS
N
QEAGG
SSI
--
-
-
--ELAEAEYM
V
R
A
SGY
LQT
L
D
D
F
NH
I
V
L
KASE
N
G
VP
V
Y
L
R
DVA
K
V
Q
I
G
P
E
MRRGI
A
EL
NG
E
G
E
V
A
G
GV
V
I
L
RS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSS
L
P
E
GV
E
IVTT
YD
RS
QL
I
DR
A
I
D
N
LSGK
L
L
E
EF
I
V
V
A
V
V
C
A
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
I
V
M
H
F
Q
G
L
N
A
N
I
MSL
S
G
I
A
I
A
V
G
A
M
VD
A
AIV
MI
EN
AH
K
R
L
E
E
WQHQHPDATL
D
NKT
R
WQ
V
IT
D
ASV
EVG
P
AL
FISLLI
I
T
LS
FIP
I
F
T
LE
G
QE
G
R
LFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------L
N
RF
L
IRV---
----
Y
HPLLL
KVL
HWPKTT
L
L
V
A
A
L
SVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TD
K
--
LIMSVPE
V
A
R
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMD
K
II
E
EL
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LST
G
IK
S
PIGIK
V
SGTVLADI
D
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
LE
GGRYIN
V
E
IN
RE
KA
A
R
Y
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DS
P
QA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DIKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YI
D
A
RDRD
M
V
S
V
V
HDLQKAIAEK
V
Q
LK
P
G
TSVA
F
S
G
--
-Q
FE
LL
E
RANHKLK
L
M
VP
M
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
Q
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAI
E
AV
PSLNNPQTFSE
QKLD
EA
LYH
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
GAGS
E
VMSR
I
A
A
PM
I
GGM
IT
A
P
LL
S
L
F
II
P
AA
Y
K
L
M
WLHRHRVRK
fig|344601.5.peg.2400
Escherichia coli B171
MIEWIIRR
S
VA
NRF
L
VLMG
A
L
F
L
S
I
W
G
TWT
I
IN
T
PV
D
AL
P
D
L
SD
V
Q
V
I
I
K
T
S
YPG
Q
A
P
Q
I
V
E
N
Q
VT
Y
PLT
TT
M
LS
V
P
G
AK
T
VRG
F
S
QF-
G
DSY
VYV
I
FE
D
GT
D
P
Y
W
A
RS
R
V
L
EY
L
N
Q
V
QGK
LP
A-----
GV
SAELGPDAT
GVG
W
I
YEY
A
LV
D
RSGKHDLA
D
L
R
S
L
Q
DWF
L
KYE
L
K
TIP
D
V
A
E
V
ASV
G
GVVKEY
QV
V
I
DP
QR
L
A
QYG
I
SLAE
V
KS
A
L
DAS
N
QEAGG
SSI
--
-
-
--ELAEAEYM
V
R
A
SGY
LQT
L
D
D
F
NH
I
V
L
KASE
N
G
VP
V
Y
L
R
DVA
K
V
Q
I
G
P
E
MRRGI
A
EL
NG
E
G
E
V
A
G
GV
V
I
L
RS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSS
L
P
E
GV
E
IVTT
YD
RS
QL
I
DR
A
I
D
N
LSGK
L
L
E
EF
I
V
V
A
V
V
C
A
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
I
V
M
H
F
Q
G
L
N
A
N
I
MSL
S
G
I
A
I
A
V
G
A
M
VD
A
AIV
MI
EN
AH
K
R
L
E
E
WQHQHPDATL
D
NKT
R
WQ
V
IT
D
ASV
EVG
P
AL
FISLLI
I
T
LS
FIP
I
F
T
LE
G
QE
G
R
LFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------L
N
RF
L
IRV---
----
Y
HPLLL
KVL
HWPKTT
L
L
V
A
A
L
SVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TD
K
--
LIMSVPE
V
A
R
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMD
K
II
E
EL
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LST
G
IK
S
PIGIK
V
SGTVLADI
D
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
LE
GGRYIN
V
E
IN
RE
KA
A
R
Y
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DS
P
QA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DIKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YI
D
A
RDRD
M
V
S
V
V
HDLQKAIAEK
V
Q
LK
P
G
TSVA
F
S
G
--
-Q
FE
LL
E
RANHKLK
L
M
VP
M
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
Q
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAI
E
AV
PSLNNPQTFSE
QKLD
EA
LYH
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
GAGS
E
VMSR
I
A
A
PM
I
GGM
IT
A
P
LL
S
L
F
II
P
AA
Y
K
L
M
WLHRHRVRK
fig|431946.3.peg.521
Escherichia coli SE15
MIEWIIRR
S
VA
NRF
L
VLMG
A
L
F
L
S
I
W
G
TWT
I
IN
T
PV
D
AL
P
D
L
SD
V
Q
V
I
I
K
T
S
YPG
Q
A
P
Q
I
V
E
N
Q
VT
Y
PLT
TT
M
LS
V
P
G
AK
T
VRG
F
S
QF-
G
DSY
VYV
I
FE
D
GT
D
P
Y
W
A
RS
R
V
L
EY
L
N
Q
V
QGK
LP
A-----
GV
SAELGPDAT
GVG
W
I
YEY
A
LV
D
RSGKHDLA
D
L
R
S
L
Q
DWF
L
KYE
L
K
TIP
D
V
A
E
V
ASV
G
GVVKEY
QV
V
I
DP
QR
L
A
QYG
I
SLAD
V
KS
A
L
DAS
N
QEAGG
SSI
--
-
-
--ELAEAEYM
V
R
A
SGY
LQT
L
D
D
F
NH
I
V
L
KASE
N
G
VP
V
Y
L
R
DVA
K
V
Q
V
G
P
E
MRRGI
A
EL
NG
E
G
E
V
A
G
GV
V
I
L
RS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSS
L
P
E
GV
E
IVTT
YD
RS
QL
I
DR
A
I
D
N
LSGK
L
L
E
EF
I
V
V
A
V
V
C
A
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
I
V
M
H
F
Q
G
L
N
A
N
I
MSL
G
G
I
A
I
A
V
G
A
M
VD
A
AIV
MI
EN
AH
K
R
L
E
E
W
L
HQHPDATL
D
NKT
R
WQ
V
IT
D
ASV
EVG
P
AL
FISLLI
I
T
LS
FIP
I
F
T
LE
G
QE
G
R
LFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------L
N
RF
L
IRV---
----
Y
HPLLL
KVL
HWPKTT
L
L
V
A
A
L
SVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TD
K
--
LIMSVPE
V
A
R
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QD
QW
R
PG--MTMD
K
II
E
EL
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LST
G
IK
S
PIGIK
V
SGTVLADI
D
T
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
LE
GGRYIN
V
E
IN
RE
KA
A
R
Y
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DS
P
QA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YI
D
A
RDRD
M
V
S
V
V
HDLQKAIAEK
V
Q
LK
P
G
TSVA
F
S
G
--
-Q
FE
LL
E
RANHKLK
L
M
VP
M
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAI
E
AE
PSLNNPQTFSE
QKLD
EA
LYH
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
GAGS
E
VMSR
I
A
A
PM
I
GGM
IT
A
P
LL
S
L
F
II
P
AA
Y
K
L
M
WLHRHRVRK
fig|749531.3.peg.3440
Escherichia coli MS 69-1
MIEWIIRR
S
VA
NRF
L
VLMG
A
L
F
L
S
I
W
G
TWT
I
IN
T
PV
D
AL
P
D
L
SD
V
Q
V
I
I
K
T
S
YPG
Q
A
P
Q
I
V
E
N
Q
VT
Y
PLT
TT
M
LS
V
P
G
AK
T
VRG
F
S
QF-
G
DSY
VYV
I
FE
D
GT
D
P
Y
W
A
RS
R
V
L
EY
L
N
Q
V
QGK
LP
A-----
GV
SAELGPDAT
GVG
W
I
YEY
A
LV
D
RSGKHDLA
D
L
R
S
L
Q
DWF
L
KYE
L
K
TIP
D
V
A
E
V
ASV
G
GVVKEY
QV
V
I
DP
QR
L
A
QYG
I
SLAE
V
KS
A
L
DAS
N
QEAGG
SSI
--
-
-
--ELAEAEYM
V
R
A
SGY
LQT
L
D
D
F
NH
I
V
L
KASE
N
G
VP
V
Y
L
R
DVA
K
V
Q
I
G
P
E
MRRGI
A
EL
NG
E
G
E
V
A
G
GV
V
I
L
RS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSS
L
P
E
GV
E
IVTT
YD
RS
QL
I
DR
A
I
D
N
LSGK
L
L
E
EF
I
V
V
A
V
V
C
A
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
I
V
M
H
F
Q
G
L
N
A
N
I
MSL
G
G
I
A
I
A
V
G
A
M
VD
A
AIV
MI
EN
AH
K
R
L
E
E
WQHQHPDATL
D
NKT
R
WQ
V
IT
D
ASV
EVG
P
AL
FISLLI
I
T
LS
FIP
I
F
T
LE
G
QE
G
R
LFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------L
N
RF
L
IRA---
----
Y
HPLLL
KVL
HWPKTT
L
L
V
A
A
L
SVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TD
K
--
LIMSVPE
V
A
R
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QD
QW
R
PG--MTMD
K
II
E
EL
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LST
G
IK
S
PIGIK
V
SGTVLADI
D
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
LE
GGRYIN
V
E
IN
RE
KA
A
R
Y
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
NS
P
QA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YI
D
A
RDRD
M
V
S
V
V
HDLQKAIAEK
V
Q
LK
P
G
TSVT
F
S
G
--
-Q
FE
LL
E
RANHKLK
L
M
VP
M
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAI
E
VE
PSLNNPQTFSE
QKLD
EA
LYH
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
GAGS
E
VMSR
I
A
A
PM
I
GGM
IT
A
P
LL
S
L
F
II
P
AA
Y
K
L
M
WLHRHRVRK
fig|405955.13.peg.550
Escherichia coli APEC O1
MIEWIIRR
S
VA
NRF
L
VLMG
A
L
F
L
S
I
W
G
TWT
I
IN
T
PV
D
AL
P
D
L
SD
V
Q
V
I
I
K
T
S
YPG
Q
A
P
Q
I
V
E
N
Q
VT
Y
PLT
TT
M
LS
V
P
G
AK
T
VRG
F
S
QF-
G
DSY
VYV
I
FE
D
GT
D
P
Y
W
A
RS
R
V
L
EY
L
N
Q
V
QGK
LP
A-----
GV
SAELGPDAT
GVG
W
I
YEY
A
LV
D
RRGKHDLA
D
L
R
S
L
Q
DWF
L
KYE
L
K
TIP
D
V
A
E
V
ASV
G
GVVKEY
QV
V
I
DP
QR
L
A
QYG
I
SLAE
V
KS
A
L
DAS
N
QEAGG
SSI
--
-
-
--ELAEAEYM
V
R
A
SGY
LQT
L
D
D
F
NH
I
V
L
KASE
N
G
VP
V
Y
L
R
DVA
K
V
Q
V
G
P
E
MRRGI
A
EL
NG
E
G
E
V
A
G
GV
V
I
L
RS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSS
L
P
E
GV
E
IVTT
YD
RS
QL
I
DR
A
I
D
N
LSGK
L
L
E
EF
I
V
V
A
V
V
C
A
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
I
V
M
H
F
Q
G
L
N
A
N
I
MSL
G
G
I
A
I
A
V
G
A
M
VD
A
AIV
MI
EN
AH
K
R
L
E
E
WQHQHPDATL
D
NKT
R
WQ
V
IT
D
ASV
EVG
P
AL
FISLLI
I
T
LS
FIP
I
F
T
LE
G
QE
G
R
LFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------L
N
RF
L
IRV---
----
Y
HPLLL
KVL
HWPKTT
L
L
V
A
A
L
SVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TD
K
--
LIMSVPE
V
A
R
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QD
QW
R
PG--MTMD
K
II
E
EL
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LST
G
IK
S
PIGIK
V
SGTVLADI
D
T
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
LE
GGRYIN
V
E
IN
RE
KA
A
R
Y
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DS
P
QA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YI
D
A
RDRD
M
V
S
V
V
HDLQKAIAEK
V
Q
LK
P
G
TSVA
F
S
G
--
-Q
FE
LL
E
RANHKLK
L
M
VP
M
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
G
A
A
EFGV
V
M
L
M
YL
RHAI
E
AE
PSLNNPQTFSE
QKLD
EA
LYH
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
GAGS
E
VMSR
I
A
A
PM
I
GGM
IT
A
P
LL
S
L
F
II
P
AA
Y
K
L
M
WLHRHRVRK
fig|405955.9.peg.452
Escherichia coli APEC O1
MIEWIIRR
S
VA
NRF
L
VLMG
A
L
F
L
S
I
W
G
TWT
I
IN
T
PV
D
AL
P
D
L
SD
V
Q
V
I
I
K
T
S
YPG
Q
A
P
Q
I
V
E
N
Q
VT
Y
PLT
TT
M
LS
V
P
G
AK
T
VRG
F
S
QF-
G
DSY
VYV
I
FE
D
GT
D
P
Y
W
A
RS
R
V
L
EY
L
N
Q
V
QGK
LP
A-----
GV
SAELGPDAT
GVG
W
I
YEY
A
LV
D
RRGKHDLA
D
L
R
S
L
Q
DWF
L
KYE
L
K
TIP
D
V
A
E
V
ASV
G
GVVKEY
QV
V
I
DP
QR
L
A
QYG
I
SLAE
V
KS
A
L
DAS
N
QEAGG
SSI
--
-
-
--ELAEAEYM
V
R
A
SGY
LQT
L
D
D
F
NH
I
V
L
KASE
N
G
VP
V
Y
L
R
DVA
K
V
Q
V
G
P
E
MRRGI
A
EL
NG
E
G
E
V
A
G
GV
V
I
L
RS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSS
L
P
E
GV
E
IVTT
YD
RS
QL
I
DR
A
I
D
N
LSGK
L
L
E
EF
I
V
V
A
V
V
C
A
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
I
V
M
H
F
Q
G
L
N
A
N
I
MSL
G
G
I
A
I
A
V
G
A
M
VD
A
AIV
MI
EN
AH
K
R
L
E
E
WQHQHPDATL
D
NKT
R
WQ
V
IT
D
ASV
EVG
P
AL
FISLLI
I
T
LS
FIP
I
F
T
LE
G
QE
G
R
LFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------L
N
RF
L
IRV---
----
Y
HPLLL
KVL
HWPKTT
L
L
V
A
A
L
SVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TD
K
--
LIMSVPE
V
A
R
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QD
QW
R
PG--MTMD
K
II
E
EL
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LST
G
IK
S
PIGIK
V
SGTVLADI
D
T
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
LE
GGRYIN
V
E
IN
RE
KA
A
R
Y
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DS
P
QA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YI
D
A
RDRD
M
V
S
V
V
HDLQKAIAEK
V
Q
LK
P
G
TSVA
F
S
G
--
-Q
FE
LL
E
RANHKLK
L
M
VP
M
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
G
A
A
EFGV
V
M
L
M
YL
RHAI
E
AE
PSLNNPQTFSE
QKLD
EA
LYH
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
GAGS
E
VMSR
I
A
A
PM
I
GGM
IT
A
P
LL
S
L
F
II
P
AA
Y
K
L
M
WLHRHRVRK
fig|316401.4.peg.692
Escherichia coli ETEC H10407
MIEWIIRR
S
VA
NRF
L
VLMG
A
L
F
L
S
I
W
G
TWT
I
IN
T
PV
D
AL
P
D
L
SD
V
Q
V
I
I
K
T
S
YPG
Q
A
P
Q
I
V
E
N
Q
VT
Y
PLT
TT
M
LS
V
P
G
AK
T
VRG
F
S
QF-
G
DSY
VYV
I
FE
D
GT
D
P
Y
W
A
RS
R
V
L
EY
L
N
Q
V
QGK
LP
A-----
GV
SAELGPDAT
GVG
W
I
YEY
A
LV
D
RSGKHDLA
D
L
R
S
L
Q
DWF
L
KYE
L
K
TIP
D
V
A
E
V
ASV
G
GVVKEY
QV
V
I
DP
QR
L
A
QYG
I
SLAE
V
KS
A
L
DAS
N
QEAGG
SSI
--
-
-
--ELAEAEYM
V
R
A
SGY
LQT
L
D
D
F
NH
I
V
L
KASE
N
G
VP
V
Y
L
R
DVA
K
V
Q
I
G
P
E
MRRGI
A
EL
NG
E
G
E
V
A
G
GV
V
I
L
RS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSS
L
P
E
GV
E
IVTT
YD
RS
QL
I
DR
A
I
D
N
LSGK
L
L
E
EF
I
V
V
A
V
V
C
A
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
I
V
M
P
F
Q
G
L
N
A
N
I
MSL
G
G
I
A
I
A
V
G
A
M
VD
A
AIV
MI
EN
AH
K
R
L
E
E
WQHQHPDA
M
L
D
NKT
R
WQ
V
IT
D
ASV
EVG
P
AL
FISLLI
I
T
LS
FIP
I
F
T
LE
G
QE
G
R
LFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------L
N
RF
L
IRV---
----
Y
HPLLL
KVL
HWPKTT
L
L
V
A
A
L
SVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TD
K
--
LIMSVPE
V
A
R
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMD
K
II
E
EL
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LST
G
IK
S
PIGIK
V
SGTVLADI
D
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
LE
GGRYIN
V
E
IN
RE
KA
A
R
Y
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DS
P
QA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DIKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YI
D
A
RDRD
M
V
S
V
V
HDLQKAIAEK
V
Q
LK
P
G
TSVA
F
S
G
--
-Q
FE
LL
E
RANHKLK
L
M
VP
M
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAI
E
AV
PSLNNPQTFSE
QKLD
EA
LYH
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
GAGS
E
VMSR
I
A
A
PM
I
GGM
IT
A
P
LL
S
L
F
II
P
AA
Y
K
L
M
WLHRHRVRK
fig|656379.3.peg.1353
Escherichia coli FVEC1302
MIEWIIRR
S
VA
NRF
L
VLMG
A
L
C
L
S
I
W
G
TWT
I
IN
T
PV
D
AL
P
D
L
SD
V
Q
V
I
I
K
T
S
YPG
Q
A
P
Q
I
V
E
N
Q
VT
Y
PLT
TT
M
LS
V
P
G
AK
T
VRG
F
S
QF-
G
DSY
VYV
I
FE
D
GT
D
P
Y
W
A
RS
R
V
L
EY
L
N
Q
V
QGK
LP
A-----
GV
SAELGPDAT
GVG
W
I
YEY
A
LV
D
RSGKHDLA
D
L
R
S
L
Q
DWF
L
KYE
L
K
TIP
D
V
A
E
V
ASV
G
GVVKEY
QV
V
I
DP
QR
L
A
QYG
I
SLAE
V
KS
A
L
DAS
N
QEAGG
SSI
--
-
-
--ELAEAEYM
V
R
A
SGY
LQT
L
D
D
F
NH
I
V
L
KASE
N
G
VP
V
Y
L
R
DVA
K
V
Q
I
G
P
E
MRRGI
A
EL
S
G
E
G
E
V
A
G
GV
V
I
L
RS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSS
L
P
E
GV
E
IVTT
YD
RS
QL
I
DR
A
I
D
N
LSGK
L
L
E
EF
I
V
V
A
V
V
C
A
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
I
V
M
H
F
Q
G
L
N
A
N
I
MSL
G
G
I
A
I
A
V
G
A
M
VD
A
AIV
MI
EN
AH
K
R
L
E
E
WQHQHPDATL
D
NKT
R
WQ
V
IT
D
ASV
EVG
P
AL
FISLLI
I
T
LS
FIP
I
F
T
LE
G
QE
G
R
LFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
I
VI
P
I
L
MG
YW
I
RGKIPPESSNP------L
N
RF
L
IRA---
----
Y
HPLLL
KVL
HWPKTT
L
L
V
A
A
L
SVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TD
K
--
LIMSVPE
V
A
R
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QD
QW
R
PG--MTMD
K
II
E
EL
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LST
G
IK
S
PIGIK
V
SGTVLADI
D
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
LE
GGRYIN
V
E
IN
RE
KA
A
R
Y
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DS
P
QA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YI
D
A
RDRD
M
V
S
V
V
HDLQKAIAEK
V
Q
LK
P
G
TSVA
F
S
G
--
-Q
FE
LL
E
RANHKLK
L
M
VP
M
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAI
E
AE
PSLNNPQTFSE
QKLD
EA
LYH
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
GAGS
E
VMSR
I
A
A
PM
I
GGM
IT
A
P
LL
S
L
F
II
P
AA
Y
K
L
M
WLHRHRVRK
fig|656380.3.peg.1181
Escherichia coli FVEC1412
MIEWIIRR
S
VA
NRF
L
VLMG
A
L
C
L
S
I
W
G
TWT
I
IN
T
PV
D
AL
P
D
L
SD
V
Q
V
I
I
K
T
S
YPG
Q
A
P
Q
I
V
E
N
Q
VT
Y
PLT
TT
M
LS
V
P
G
AK
T
VRG
F
S
QF-
G
DSY
VYV
I
FE
D
GT
D
P
Y
W
A
RS
R
V
L
EY
L
N
Q
V
QGK
LP
A-----
GV
SAELGPDAT
GVG
W
I
YEY
A
LV
D
RSGKHDLA
D
L
R
S
L
Q
DWF
L
KYE
L
K
TIP
D
V
A
E
V
ASV
G
GVVKEY
QV
V
I
DP
QR
L
A
QYG
I
SLAE
V
KS
A
L
DAS
N
QEAGG
SSI
--
-
-
--ELAEAEYM
V
R
A
SGY
LQT
L
D
D
F
NH
I
V
L
KASE
N
G
VP
V
Y
L
R
DVA
K
V
Q
I
G
P
E
MRRGI
A
EL
S
G
E
G
E
V
A
G
GV
V
I
L
RS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSS
L
P
E
GV
E
IVTT
YD
RS
QL
I
DR
A
I
D
N
LSGK
L
L
E
EF
I
V
V
A
V
V
C
A
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
I
V
M
H
F
Q
G
L
N
A
N
I
MSL
G
G
I
A
I
A
V
G
A
M
VD
A
AIV
MI
EN
AH
K
R
L
E
E
WQHQHPDATL
D
NKT
R
WQ
V
IT
D
ASV
EVG
P
AL
FISLLI
I
T
LS
FIP
I
F
T
LE
G
QE
G
R
LFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
I
VI
P
I
L
MG
YW
I
RGKIPPESSNP------L
N
RF
L
IRA---
----
Y
HPLLL
KVL
HWPKTT
L
L
V
A
A
L
SVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TD
K
--
LIMSVPE
V
A
R
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QD
QW
R
PG--MTMD
K
II
E
EL
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LST
G
IK
S
PIGIK
V
SGTVLADI
D
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
LE
GGRYIN
V
E
IN
RE
KA
A
R
Y
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DS
P
QA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YI
D
A
RDRD
M
V
S
V
V
HDLQKAIAEK
V
Q
LK
P
G
TSVA
F
S
G
--
-Q
FE
LL
E
RANHKLK
L
M
VP
M
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAI
E
AE
PSLNNPQTFSE
QKLD
EA
LYH
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
GAGS
E
VMSR
I
A
A
PM
I
GGM
IT
A
P
LL
S
L
F
II
P
AA
Y
K
L
M
WLHRHRVRK
fig|749549.3.peg.4797
Escherichia coli MS 198-1
MIEWIIRR
S
VA
NRF
L
VLMG
A
L
C
L
S
I
W
G
TWT
I
IN
T
PV
D
AL
P
D
L
SD
V
Q
V
I
I
K
T
S
YPG
Q
A
P
Q
I
V
E
N
Q
VT
Y
PLT
TT
M
LS
V
P
G
AK
T
VRG
F
S
QF-
G
DSY
VYV
I
FE
D
GT
D
P
Y
W
A
RS
R
V
L
EY
L
N
Q
V
QGK
LP
A-----
GV
SAELGPDAT
GVG
W
I
YEY
A
LV
D
RSGKHDLA
D
L
R
S
L
Q
DWF
L
KYE
L
K
TIP
D
V
A
E
V
ASV
G
GVVKEY
QV
V
I
DP
QR
L
A
QYG
I
SLAE
V
KS
A
L
DAS
N
QEAGG
SSI
--
-
-
--ELAEAEYM
V
R
A
SGY
LQT
L
D
D
F
NH
I
V
L
KASE
N
G
VP
V
Y
L
R
DVA
K
V
Q
I
G
P
E
MRRGI
A
EL
S
G
E
G
E
V
A
G
GV
V
I
L
RS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSS
L
P
E
GV
E
IVTT
YD
RS
QL
I
DR
A
I
D
N
LSGK
L
L
E
EF
I
V
V
A
V
V
C
A
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
I
V
M
H
F
Q
G
L
N
A
N
I
MSL
G
G
I
A
I
A
V
G
A
M
VD
A
AIV
MI
EN
AH
K
R
L
E
E
WQHQHPDATL
D
NKT
R
WQ
V
IT
D
ASV
EVG
P
AL
FISLLI
I
T
LS
FIP
I
F
T
LE
G
QE
G
R
LFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
I
VI
P
I
L
MG
YW
I
RGKIPPESSNP------L
N
RF
L
IRA---
----
Y
HPLLL
KVL
HWPKTT
L
L
V
A
A
L
SVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TD
K
--
LIMSVPE
V
A
R
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QD
QW
R
PG--MTMD
K
II
E
EL
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LST
G
IK
S
PIGIK
V
SGTVLADI
D
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
LE
GGRYIN
V
E
IN
RE
KA
A
R
Y
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DS
P
QA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YI
D
A
RDRD
M
V
S
V
V
HDLQKAIAEK
V
Q
LK
P
G
TSVA
F
S
G
--
-Q
FE
LL
E
RANHKLK
L
M
VP
M
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAI
E
AE
PSLNNPQTFSE
QKLD
EA
LYH
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
GAGS
E
VMSR
I
A
A
PM
I
GGM
IT
A
P
LL
S
L
F
II
P
AA
Y
K
L
M
WLHRHRVRK
fig|585056.7.peg.862
Escherichia coli UMN026
MIEWIIRR
S
VA
NRF
L
VLMG
A
L
C
L
S
I
W
G
TWT
I
IN
T
PV
D
AL
P
D
L
SD
V
Q
V
I
I
K
T
S
YPG
Q
A
P
Q
I
V
E
N
Q
VT
Y
PLT
TT
M
LS
V
P
G
AK
T
VRG
F
S
QF-
G
DSY
VYV
I
FE
D
GT
D
P
Y
W
A
RS
R
V
L
EY
L
N
Q
V
QGK
LP
A-----
GV
SAELGPDAT
GVG
W
I
YEY
A
LV
D
RSGKHDLA
D
L
R
S
L
Q
DWF
L
KYE
L
K
TIP
D
V
A
E
V
ASV
G
GVVKEY
QV
V
I
DP
QR
L
A
QYG
I
SLAE
V
KS
A
L
DAS
N
QEAGG
SSI
--
-
-
--ELAEAEYM
V
R
A
SGY
LQT
L
D
D
F
NH
I
V
L
KASE
N
G
VP
V
Y
L
R
DVA
K
V
Q
I
G
P
E
MRRGI
A
EL
S
G
E
G
E
V
A
G
GV
V
I
L
RS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSS
L
P
E
GV
E
IVTT
YD
RS
QL
I
DR
A
I
D
N
LSGK
L
L
E
EF
I
V
V
A
V
V
C
A
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
I
V
M
H
F
Q
G
L
N
A
N
I
MSL
G
G
I
A
I
A
V
G
A
M
VD
A
AIV
MI
EN
AH
K
R
L
E
E
WQHQHPDATL
D
NKT
R
WQ
V
IT
D
ASV
EVG
P
AL
FISLLI
I
T
LS
FIP
I
F
T
LE
G
QE
G
R
LFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
I
VI
P
I
L
MG
YW
I
RGKIPPESSNP------L
N
RF
L
IRA---
----
Y
HPLLL
KVL
HWPKTT
L
L
V
A
A
L
SVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TD
K
--
LIMSVPE
V
A
R
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QD
QW
R
PG--MTMD
K
II
E
EL
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LST
G
IK
S
PIGIK
V
SGTVLADI
D
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
LE
GGRYIN
V
E
IN
RE
KA
A
R
Y
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DS
P
QA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YI
D
A
RDRD
M
V
S
V
V
HDLQKAIAEK
V
Q
LK
P
G
TSVA
F
S
G
--
-Q
FE
LL
E
RANHKLK
L
M
VP
M
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAI
E
AE
PSLNNPQTFSE
QKLD
EA
LYH
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
GAGS
E
VMSR
I
A
A
PM
I
GGM
IT
A
P
LL
S
L
F
II
P
AA
Y
K
L
M
WLHRHRVRK
fig|550676.3.peg.38
Escherichia coli B185
MIEWIIRR
S
VA
NRF
L
VLMG
A
L
F
L
S
I
W
G
TWT
I
IN
T
PV
D
AL
P
D
L
SD
V
Q
V
I
I
K
T
S
YPG
Q
A
P
Q
I
V
E
N
Q
VT
Y
PLT
TT
M
LS
V
P
G
AK
T
VRG
F
S
QF-
G
DSY
VYV
I
FE
D
GT
D
P
Y
W
A
RS
R
V
L
EY
L
N
Q
V
QGK
LP
A-----
GV
SAELGPDAT
GVG
W
I
YEY
A
LV
D
RSGKHDLA
D
L
R
S
L
Q
DWF
L
KYE
L
K
TIP
D
V
A
E
V
ASV
G
GVVKEY
QV
V
I
DP
QR
L
A
QYG
I
SLAE
V
KS
A
L
DAS
N
QEAGG
SSI
--
-
-
--ELAEAEYM
V
R
A
SGY
LQT
L
D
D
F
NH
I
V
L
KASE
N
G
VP
V
Y
L
R
DVA
K
I
Q
V
G
P
E
MRRGI
A
EL
NG
E
G
E
V
A
G
GV
V
I
L
RS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSS
L
P
E
GV
E
IVTT
YD
RS
QL
I
DR
A
I
D
N
LSGK
L
L
E
EF
I
V
V
A
V
V
C
A
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
I
V
M
H
F
Q
G
L
N
A
N
I
MSL
G
G
I
A
I
A
V
G
A
M
VD
A
AIV
MI
EN
AH
K
R
L
E
E
WQHQHPDATL
D
NKT
R
WQ
V
IT
D
ASV
EVG
P
AL
FISLLI
I
T
LS
FIP
I
F
T
LE
G
QE
G
R
LFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------L
N
RF
L
IRV---
----
Y
HPLLL
KVL
HRPKTT
L
L
V
A
A
L
SVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TD
K
--
LIMSVPE
V
A
R
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QD
QW
R
PG--MTMD
K
II
E
EL
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LST
G
IK
S
PIGIK
V
SGTVLADI
D
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
LE
GGRYIN
V
E
IN
RE
KA
A
R
Y
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DS
P
QA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YI
D
A
RDRD
M
V
S
V
V
HDLQKAIAEK
V
Q
LK
P
G
TSVA
F
S
G
--
-Q
FE
LL
E
RANHKLK
L
M
VP
M
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
V
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAI
E
AE
PSLNNPQTFSE
QKLD
EA
LYH
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
GAGS
E
VMSR
I
A
A
PM
I
GGM
IT
A
P
LL
S
L
F
II
P
AA
Y
K
L
M
WLHRHRVRK
fig|562.371.peg.2826
Escherichia coli 1044A
MIEWIIRR
S
VA
NRF
L
VLMG
A
L
F
L
S
I
W
G
TWT
I
IN
T
PV
D
AL
P
D
L
SD
V
Q
V
I
I
K
T
S
YPG
Q
A
P
Q
I
V
E
N
Q
VT
Y
PLT
TT
M
LS
V
P
G
AK
T
VRG
F
S
QF-
G
DSY
VYV
I
FE
D
GT
D
P
Y
W
A
RS
R
V
L
EY
L
N
Q
V
QGK
LP
A-----
GV
SAELGPDAT
GVG
W
I
YEY
A
LV
D
RSGKHDLA
D
L
R
S
L
Q
DWF
L
KYE
L
K
TIP
D
V
A
E
V
ASV
G
GVVKEY
QV
V
I
DP
QR
L
A
QYG
I
SLAE
V
KS
A
L
DAS
N
QEAGG
SSI
--
-
-
--ELAEAEYM
V
R
A
SGY
LQT
L
D
D
F
NH
I
V
L
KASE
N
G
VP
V
Y
L
R
DVA
K
I
Q
V
G
P
E
MRRGI
A
EL
N
--
G
E
V
V
G
GV
V
I
L
RS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSS
L
P
E
GV
E
IVTT
YD
RS
QL
I
DR
A
I
D
N
LSGK
L
L
E
EF
I
V
V
A
V
V
C
A
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
I
V
M
H
F
Q
G
L
N
A
N
I
MSL
G
G
I
A
I
A
V
G
A
M
VD
A
AIV
MI
EN
AH
K
R
L
E
E
WQHQHPDATL
D
NKT
R
WQ
V
IT
N
ASV
EVG
P
AL
FISLLI
I
T
LS
FIP
I
F
T
LE
G
QE
G
R
LFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------L
N
RF
L
IRV---
----
Y
HPLLL
KVL
HWPKTT
L
L
V
A
A
L
SVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TD
K
--
LIMSVPE
V
A
R
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMD
K
II
E
EL
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LST
G
IK
S
PIGIK
V
SGTVLADI
D
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
LE
GGRYIN
V
E
IN
RE
KA
A
R
Y
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DS
P
QA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YI
D
A
RDRD
M
V
S
V
V
HDLQKAIAEK
V
Q
LK
P
G
TSVA
F
S
G
--
-Q
FE
LL
E
RANHKLK
L
M
VP
M
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAI
E
AE
PSLNNPQTFSE
QKLD
EA
LHH
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
GAGS
E
VMSR
I
A
A
PM
I
GGM
IT
A
P
LL
S
L
F
II
P
AA
Y
K
L
M
WLHRHRVRK
fig|562.373.peg.3167
Escherichia coli 1125A
MIEWIIRR
S
VA
NRF
L
VLMG
A
L
F
L
S
I
W
G
TWT
I
IN
T
PV
D
AL
P
D
L
SD
V
Q
V
I
I
K
T
S
YPG
Q
A
P
Q
I
V
E
N
Q
VT
Y
PLT
TT
M
LS
V
P
G
AK
T
VRG
F
S
QF-
G
DSY
VYV
I
FE
D
GT
D
P
Y
W
A
RS
R
V
L
EY
L
N
Q
V
QGK
LP
A-----
GV
SAELGPDAT
GVG
W
I
YEY
A
LV
D
RSGKHDLA
D
L
R
S
L
Q
DWF
L
KYE
L
K
TIP
D
V
A
E
V
ASV
G
GVVKEY
QV
V
I
DP
QR
L
A
QYG
I
SLAE
V
KS
A
L
DAS
N
QEAGG
SSI
--
-
-
--ELAEAEYM
V
R
A
SGY
LQT
L
D
D
F
NH
I
V
L
KASE
N
G
VP
V
Y
L
R
DVA
K
I
Q
V
G
P
E
MRRGI
A
EL
N
--
G
E
V
V
G
GV
V
I
L
RS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSS
L
P
E
GV
E
IVTT
YD
RS
QL
I
DR
A
I
D
N
LSGK
L
L
E
EF
I
V
V
A
V
V
C
A
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
I
V
M
H
F
Q
G
L
N
A
N
I
MSL
G
G
I
A
I
A
V
G
A
M
VD
A
AIV
MI
EN
AH
K
R
L
E
E
WQHQHPDATL
D
NKT
R
WQ
V
IT
N
ASV
EVG
P
AL
FISLLI
I
T
LS
FIP
I
F
T
LE
G
QE
G
R
LFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------L
N
RF
L
IRV---
----
Y
HPLLL
KVL
HWPKTT
L
L
V
A
A
L
SVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TD
K
--
LIMSVPE
V
A
R
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMD
K
II
E
EL
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LST
G
IK
S
PIGIK
V
SGTVLADI
D
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
LE
GGRYIN
V
E
IN
RE
KA
A
R
Y
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DS
P
QA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YI
D
A
RDRD
M
V
S
V
V
HDLQKAIAEK
V
Q
LK
P
G
TSVA
F
S
G
--
-Q
FE
LL
E
RANHKLK
L
M
VP
M
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAI
E
AE
PSLNNPQTFSE
QKLD
EA
LHH
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
GAGS
E
VMSR
I
A
A
PM
I
GGM
IT
A
P
LL
S
L
F
II
P
AA
Y
K
L
M
WLHRHRVRK
fig|562.372.peg.1557
Escherichia coli 1212A
MIEWIIRR
S
VA
NRF
L
VLMG
A
L
F
L
S
I
W
G
TWT
I
IN
T
PV
D
AL
P
D
L
SD
V
Q
V
I
I
K
T
S
YPG
Q
A
P
Q
I
V
E
N
Q
VT
Y
PLT
TT
M
LS
V
P
G
AK
T
VRG
F
S
QF-
G
DSY
VYV
I
FE
D
GT
D
P
Y
W
A
RS
R
V
L
EY
L
N
Q
V
QGK
LP
A-----
GV
SAELGPDAT
GVG
W
I
YEY
A
LV
D
RSGKHDLA
D
L
R
S
L
Q
DWF
L
KYE
L
K
TIP
D
V
A
E
V
ASV
G
GVVKEY
QV
V
I
DP
QR
L
A
QYG
I
SLAE
V
KS
A
L
DAS
N
QEAGG
SSI
--
-
-
--ELAEAEYM
V
R
A
SGY
LQT
L
D
D
F
NH
I
V
L
KASE
N
G
VP
V
Y
L
R
DVA
K
I
Q
V
G
P
E
MRRGI
A
EL
N
--
G
E
V
V
G
GV
V
I
L
RS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSS
L
P
E
GV
E
IVTT
YD
RS
QL
I
DR
A
I
D
N
LSGK
L
L
E
EF
I
V
V
A
V
V
C
A
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
I
V
M
H
F
Q
G
L
N
A
N
I
MSL
G
G
I
A
I
A
V
G
A
M
VD
A
AIV
MI
EN
AH
K
R
L
E
E
WQHQHPDATL
D
NKT
R
WQ
V
IT
N
ASV
EVG
P
AL
FISLLI
I
T
LS
FIP
I
F
T
LE
G
QE
G
R
LFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------L
N
RF
L
IRV---
----
Y
HPLLL
KVL
HWPKTT
L
L
V
A
A
L
SVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TD
K
--
LIMSVPE
V
A
R
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMD
K
II
E
EL
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LST
G
IK
S
PIGIK
V
SGTVLADI
D
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
LE
GGRYIN
V
E
IN
RE
KA
A
R
Y
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DS
P
QA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YI
D
A
RDRD
M
V
S
V
V
HDLQKAIAEK
V
Q
LK
P
G
TSVA
F
S
G
--
-Q
FE
LL
E
RANHKLK
L
M
VP
M
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAI
E
AE
PSLNNPQTFSE
QKLD
EA
LHH
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
GAGS
E
VMSR
I
A
A
PM
I
GGM
IT
A
P
LL
S
L
F
II
P
AA
Y
K
L
M
WLHRHRVRK
fig|562.374.peg.5419
Escherichia coli 536A
MIEWIIRR
S
VA
NRF
L
VLMG
A
L
F
L
S
I
W
G
TWT
I
IN
T
PV
D
AL
P
D
L
SD
V
Q
V
I
I
K
T
S
YPG
Q
A
P
Q
I
V
E
N
Q
VT
Y
PLT
TT
M
LS
V
P
G
AK
T
VRG
F
S
QF-
G
DSY
VYV
I
FE
D
GT
D
P
Y
W
A
RS
R
V
L
EY
L
N
Q
V
QGK
LP
A-----
GV
SAELGPDAT
GVG
W
I
YEY
A
LV
D
RSGKHDLA
D
L
R
S
L
Q
DWF
L
KYE
L
K
TIP
D
V
A
E
V
ASV
G
GVVKEY
QV
V
I
DP
QR
L
A
QYG
I
SLAE
V
KS
A
L
DAS
N
QEAGG
SSI
--
-
-
--ELAEAEYM
V
R
A
SGY
LQT
L
D
D
F
NH
I
V
L
KASE
N
G
VP
V
Y
L
R
DVA
K
I
Q
V
G
P
E
MRRGI
A
EL
N
--
G
E
V
V
G
GV
V
I
L
RS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSS
L
P
E
GV
E
IVTT
YD
RS
QL
I
DR
A
I
D
N
LSGK
L
L
E
EF
I
V
V
A
V
V
C
A
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
I
V
M
H
F
Q
G
L
N
A
N
I
MSL
G
G
I
A
I
A
V
G
A
M
VD
A
AIV
MI
EN
AH
K
R
L
E
E
WQHQHPDATL
D
NKT
R
WQ
V
IT
N
ASV
EVG
P
AL
FISLLI
I
T
LS
FIP
I
F
T
LE
G
QE
G
R
LFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------L
N
RF
L
IRV---
----
Y
HPLLL
KVL
HWPKTT
L
L
V
A
A
L
SVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TD
K
--
LIMSVPE
V
A
R
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMD
K
II
E
EL
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LST
G
IK
S
PIGIK
V
SGTVLADI
D
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
LE
GGRYIN
V
E
IN
RE
KA
A
R
Y
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DS
P
QA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YI
D
A
RDRD
M
V
S
V
V
HDLQKAIAEK
V
Q
LK
P
G
TSVA
F
S
G
--
-Q
FE
LL
E
RANHKLK
L
M
VP
M
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAI
E
AE
PSLNNPQTFSE
QKLD
EA
LHH
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
GAGS
E
VMSR
I
A
A
PM
I
GGM
IT
A
P
LL
S
L
F
II
P
AA
Y
K
L
M
WLHRHRVRK
fig|83334.1.peg.686
Escherichia coli O157:H7
MIEWIIRR
S
VA
NRF
L
VLMG
A
L
F
L
S
I
W
G
TWT
I
IN
T
PV
D
AL
P
D
L
SD
V
Q
V
I
I
K
T
S
YPG
Q
A
P
Q
I
V
E
N
Q
VT
Y
PLT
TT
M
LS
V
P
G
AK
T
VRG
F
S
QF-
G
DSY
VYV
I
FE
D
GT
D
P
Y
W
A
RS
R
V
L
EY
L
N
Q
V
QGK
LP
A-----
GV
SAELGPDAT
GVG
W
I
YEY
A
LV
D
RSGKHDLA
D
L
R
S
L
Q
DWF
L
KYE
L
K
TIP
D
V
A
E
V
ASV
G
GVVKEY
QV
V
I
DP
QR
L
A
QYG
I
SLAE
V
KS
A
L
DAS
N
QEAGG
SSI
--
-
-
--ELAEAEYM
V
R
A
SGY
LQT
L
D
D
F
NH
I
V
L
KASE
N
G
VP
V
Y
L
R
DVA
K
I
Q
V
G
P
E
MRRGI
A
EL
N
--
G
E
V
V
G
GV
V
I
L
RS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSS
L
P
E
GV
E
IVTT
YD
RS
QL
I
DR
A
I
D
N
LSGK
L
L
E
EF
I
V
V
A
V
V
C
A
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
I
V
M
H
F
Q
G
L
N
A
N
I
MSL
G
G
I
A
I
A
V
G
A
M
VD
A
AIV
MI
EN
AH
K
R
L
E
E
WQHQHPDATL
D
NKT
R
WQ
V
IT
N
ASV
EVG
P
AL
FISLLI
I
T
LS
FIP
I
F
T
LE
G
QE
G
R
LFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------L
N
RF
L
IRV---
----
Y
HPLLL
KVL
HWPKTT
L
L
V
A
A
L
SVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TD
K
--
LIMSVPE
V
A
R
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMD
K
II
E
EL
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LST
G
IK
S
PIGIK
V
SGTVLADI
D
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
LE
GGRYIN
V
E
IN
RE
KA
A
R
Y
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DS
P
QA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YI
D
A
RDRD
M
V
S
V
V
HDLQKAIAEK
V
Q
LK
P
G
TSVA
F
S
G
--
-Q
FE
LL
E
RANHKLK
L
M
VP
M
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAI
E
AE
PSLNNPQTFSE
QKLD
EA
LHH
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
GAGS
E
VMSR
I
A
A
PM
I
GGM
IT
A
P
LL
S
L
F
II
P
AA
Y
K
L
M
WLHRHRVRK
fig|155864.1.peg.608
Escherichia coli O157:H7 EDL933
MIEWIIRR
S
VA
NRF
L
VLMG
A
L
F
L
S
I
W
G
TWT
I
IN
T
PV
D
AL
P
D
L
SD
V
Q
V
I
I
K
T
S
YPG
Q
A
P
Q
I
V
E
N
Q
VT
Y
PLT
TT
M
LS
V
P
G
AK
T
VRG
F
S
QF-
G
DSY
VYV
I
FE
D
GT
D
P
Y
W
A
RS
R
V
L
EY
L
N
Q
V
QGK
LP
A-----
GV
SAELGPDAT
GVG
W
I
YEY
A
LV
D
RSGKHDLA
D
L
R
S
L
Q
DWF
L
KYE
L
K
TIP
D
V
A
E
V
ASV
G
GVVKEY
QV
V
I
DP
QR
L
A
QYG
I
SLAE
V
KS
A
L
DAS
N
QEAGG
SSI
--
-
-
--ELAEAEYM
V
R
A
SGY
LQT
L
D
D
F
NH
I
V
L
KASE
N
G
VP
V
Y
L
R
DVA
K
I
Q
V
G
P
E
MRRGI
A
EL
N
--
G
E
V
V
G
GV
V
I
L
RS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSS
L
P
E
GV
E
IVTT
YD
RS
QL
I
DR
A
I
D
N
LSGK
L
L
E
EF
I
V
V
A
V
V
C
A
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
I
V
M
H
F
Q
G
L
N
A
N
I
MSL
G
G
I
A
I
A
V
G
A
M
VD
A
AIV
MI
EN
AH
K
R
L
E
E
WQHQHPDATL
D
NKT
R
WQ
V
IT
N
ASV
EVG
P
AL
FISLLI
I
T
LS
FIP
I
F
T
LE
G
QE
G
R
LFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------L
N
RF
L
IRV---
----
Y
HPLLL
KVL
HWPKTT
L
L
V
A
A
L
SVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TD
K
--
LIMSVPE
V
A
R
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMD
K
II
E
EL
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LST
G
IK
S
PIGIK
V
SGTVLADI
D
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
LE
GGRYIN
V
E
IN
RE
KA
A
R
Y
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DS
P
QA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YI
D
A
RDRD
M
V
S
V
V
HDLQKAIAEK
V
Q
LK
P
G
TSVA
F
S
G
--
-Q
FE
LL
E
RANHKLK
L
M
VP
M
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAI
E
AE
PSLNNPQTFSE
QKLD
EA
LHH
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
GAGS
E
VMSR
I
A
A
PM
I
GGM
IT
A
P
LL
S
L
F
II
P
AA
Y
K
L
M
WLHRHRVRK
fig|155864.8.peg.623
Escherichia coli O157:H7 EDL933
MIEWIIRR
S
VA
NRF
L
VLMG
A
L
F
L
S
I
W
G
TWT
I
IN
T
PV
D
AL
P
D
L
SD
V
Q
V
I
I
K
T
S
YPG
Q
A
P
Q
I
V
E
N
Q
VT
Y
PLT
TT
M
LS
V
P
G
AK
T
VRG
F
S
QF-
G
DSY
VYV
I
FE
D
GT
D
P
Y
W
A
RS
R
V
L
EY
L
N
Q
V
QGK
LP
A-----
GV
SAELGPDAT
GVG
W
I
YEY
A
LV
D
RSGKHDLA
D
L
R
S
L
Q
DWF
L
KYE
L
K
TIP
D
V
A
E
V
ASV
G
GVVKEY
QV
V
I
DP
QR
L
A
QYG
I
SLAE
V
KS
A
L
DAS
N
QEAGG
SSI
--
-
-
--ELAEAEYM
V
R
A
SGY
LQT
L
D
D
F
NH
I
V
L
KASE
N
G
VP
V
Y
L
R
DVA
K
I
Q
V
G
P
E
MRRGI
A
EL
N
--
G
E
V
V
G
GV
V
I
L
RS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSS
L
P
E
GV
E
IVTT
YD
RS
QL
I
DR
A
I
D
N
LSGK
L
L
E
EF
I
V
V
A
V
V
C
A
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
I
V
M
H
F
Q
G
L
N
A
N
I
MSL
G
G
I
A
I
A
V
G
A
M
VD
A
AIV
MI
EN
AH
K
R
L
E
E
WQHQHPDATL
D
NKT
R
WQ
V
IT
N
ASV
EVG
P
AL
FISLLI
I
T
LS
FIP
I
F
T
LE
G
QE
G
R
LFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------L
N
RF
L
IRV---
----
Y
HPLLL
KVL
HWPKTT
L
L
V
A
A
L
SVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TD
K
--
LIMSVPE
V
A
R
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMD
K
II
E
EL
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LST
G
IK
S
PIGIK
V
SGTVLADI
D
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
LE
GGRYIN
V
E
IN
RE
KA
A
R
Y
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DS
P
QA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YI
D
A
RDRD
M
V
S
V
V
HDLQKAIAEK
V
Q
LK
P
G
TSVA
F
S
G
--
-Q
FE
LL
E
RANHKLK
L
M
VP
M
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAI
E
AE
PSLNNPQTFSE
QKLD
EA
LHH
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
GAGS
E
VMSR
I
A
A
PM
I
GGM
IT
A
P
LL
S
L
F
II
P
AA
Y
K
L
M
WLHRHRVRK
fig|444454.5.peg.5098
Escherichia coli O157:H7 str. EC4024
MIEWIIRR
S
VA
NRF
L
VLMG
A
L
F
L
S
I
W
G
TWT
I
IN
T
PV
D
AL
P
D
L
SD
V
Q
V
I
I
K
T
S
YPG
Q
A
P
Q
I
V
E
N
Q
VT
Y
PLT
TT
M
LS
V
P
G
AK
T
VRG
F
S
QF-
G
DSY
VYV
I
FE
D
GT
D
P
Y
W
A
RS
R
V
L
EY
L
N
Q
V
QGK
LP
A-----
GV
SAELGPDAT
GVG
W
I
YEY
A
LV
D
RSGKHDLA
D
L
R
S
L
Q
DWF
L
KYE
L
K
TIP
D
V
A
E
V
ASV
G
GVVKEY
QV
V
I
DP
QR
L
A
QYG
I
SLAE
V
KS
A
L
DAS
N
QEAGG
SSI
--
-
-
--ELAEAEYM
V
R
A
SGY
LQT
L
D
D
F
NH
I
V
L
KASE
N
G
VP
V
Y
L
R
DVA
K
I
Q
V
G
P
E
MRRGI
A
EL
N
--
G
E
V
V
G
GV
V
I
L
RS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSS
L
P
E
GV
E
IVTT
YD
RS
QL
I
DR
A
I
D
N
LSGK
L
L
E
EF
I
V
V
A
V
V
C
A
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
I
V
M
H
F
Q
G
L
N
A
N
I
MSL
G
G
I
A
I
A
V
G
A
M
VD
A
AIV
MI
EN
AH
K
R
L
E
E
WQHQHPDATL
D
NKT
R
WQ
V
IT
N
ASV
EVG
P
AL
FISLLI
I
T
LS
FIP
I
F
T
LE
G
QE
G
R
LFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------L
N
RF
L
IRV---
----
Y
HPLLL
KVL
HWPKTT
L
L
V
A
A
L
SVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TD
K
--
LIMSVPE
V
A
R
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMD
K
II
E
EL
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LST
G
IK
S
PIGIK
V
SGTVLADI
D
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
LE
GGRYIN
V
E
IN
RE
KA
A
R
Y
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DS
P
QA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YI
D
A
RDRD
M
V
S
V
V
HDLQKAIAEK
V
Q
LK
P
G
TSVA
F
S
G
--
-Q
FE
LL
E
RANHKLK
L
M
VP
M
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAI
E
AE
PSLNNPQTFSE
QKLD
EA
LHH
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
GAGS
E
VMSR
I
A
A
PM
I
GGM
IT
A
P
LL
S
L
F
II
P
AA
Y
K
L
M
WLHRHRVRK
fig|444449.5.peg.5434
Escherichia coli O157:H7 str. EC4042
MIEWIIRR
S
VA
NRF
L
VLMG
A
L
F
L
S
I
W
G
TWT
I
IN
T
PV
D
AL
P
D
L
SD
V
Q
V
I
I
K
T
S
YPG
Q
A
P
Q
I
V
E
N
Q
VT
Y
PLT
TT
M
LS
V
P
G
AK
T
VRG
F
S
QF-
G
DSY
VYV
I
FE
D
GT
D
P
Y
W
A
RS
R
V
L
EY
L
N
Q
V
QGK
LP
A-----
GV
SAELGPDAT
GVG
W
I
YEY
A
LV
D
RSGKHDLA
D
L
R
S
L
Q
DWF
L
KYE
L
K
TIP
D
V
A
E
V
ASV
G
GVVKEY
QV
V
I
DP
QR
L
A
QYG
I
SLAE
V
KS
A
L
DAS
N
QEAGG
SSI
--
-
-
--ELAEAEYM
V
R
A
SGY
LQT
L
D
D
F
NH
I
V
L
KASE
N
G
VP
V
Y
L
R
DVA
K
I
Q
V
G
P
E
MRRGI
A
EL
N
--
G
E
V
V
G
GV
V
I
L
RS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSS
L
P
E
GV
E
IVTT
YD
RS
QL
I
DR
A
I
D
N
LSGK
L
L
E
EF
I
V
V
A
V
V
C
A
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
I
V
M
H
F
Q
G
L
N
A
N
I
MSL
G
G
I
A
I
A
V
G
A
M
VD
A
AIV
MI
EN
AH
K
R
L
E
E
WQHQHPDATL
D
NKT
R
WQ
V
IT
N
ASV
EVG
P
AL
FISLLI
I
T
LS
FIP
I
F
T
LE
G
QE
G
R
LFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------L
N
RF
L
IRV---
----
Y
HPLLL
KVL
HWPKTT
L
L
V
A
A
L
SVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TD
K
--
LIMSVPE
V
A
R
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMD
K
II
E
EL
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LST
G
IK
S
PIGIK
V
SGTVLADI
D
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
LE
GGRYIN
V
E
IN
RE
KA
A
R
Y
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DS
P
QA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YI
D
A
RDRD
M
V
S
V
V
HDLQKAIAEK
V
Q
LK
P
G
TSVA
F
S
G
--
-Q
FE
LL
E
RANHKLK
L
M
VP
M
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAI
E
AE
PSLNNPQTFSE
QKLD
EA
LHH
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
GAGS
E
VMSR
I
A
A
PM
I
GGM
IT
A
P
LL
S
L
F
II
P
AA
Y
K
L
M
WLHRHRVRK
fig|444448.5.peg.3308
Escherichia coli O157:H7 str. EC4045
MIEWIIRR
S
VA
NRF
L
VLMG
A
L
F
L
S
I
W
G
TWT
I
IN
T
PV
D
AL
P
D
L
SD
V
Q
V
I
I
K
T
S
YPG
Q
A
P
Q
I
V
E
N
Q
VT
Y
PLT
TT
M
LS
V
P
G
AK
T
VRG
F
S
QF-
G
DSY
VYV
I
FE
D
GT
D
P
Y
W
A
RS
R
V
L
EY
L
N
Q
V
QGK
LP
A-----
GV
SAELGPDAT
GVG
W
I
YEY
A
LV
D
RSGKHDLA
D
L
R
S
L
Q
DWF
L
KYE
L
K
TIP
D
V
A
E
V
ASV
G
GVVKEY
QV
V
I
DP
QR
L
A
QYG
I
SLAE
V
KS
A
L
DAS
N
QEAGG
SSI
--
-
-
--ELAEAEYM
V
R
A
SGY
LQT
L
D
D
F
NH
I
V
L
KASE
N
G
VP
V
Y
L
R
DVA
K
I
Q
V
G
P
E
MRRGI
A
EL
N
--
G
E
V
V
G
GV
V
I
L
RS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSS
L
P
E
GV
E
IVTT
YD
RS
QL
I
DR
A
I
D
N
LSGK
L
L
E
EF
I
V
V
A
V
V
C
A
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
I
V
M
H
F
Q
G
L
N
A
N
I
MSL
G
G
I
A
I
A
V
G
A
M
VD
A
AIV
MI
EN
AH
K
R
L
E
E
WQHQHPDATL
D
NKT
R
WQ
V
IT
N
ASV
EVG
P
AL
FISLLI
I
T
LS
FIP
I
F
T
LE
G
QE
G
R
LFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------L
N
RF
L
IRV---
----
Y
HPLLL
KVL
HWPKTT
L
L
V
A
A
L
SVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TD
K
--
LIMSVPE
V
A
R
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMD
K
II
E
EL
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LST
G
IK
S
PIGIK
V
SGTVLADI
D
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
LE
GGRYIN
V
E
IN
RE
KA
A
R
Y
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DS
P
QA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YI
D
A
RDRD
M
V
S
V
V
HDLQKAIAEK
V
Q
LK
P
G
TSVA
F
S
G
--
-Q
FE
LL
E
RANHKLK
L
M
VP
M
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAI
E
AE
PSLNNPQTFSE
QKLD
EA
LHH
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
GAGS
E
VMSR
I
A
A
PM
I
GGM
IT
A
P
LL
S
L
F
II
P
AA
Y
K
L
M
WLHRHRVRK
fig|444453.5.peg.650
Escherichia coli O157:H7 str. EC4076
MIEWIIRR
S
VA
NRF
L
VLMG
A
L
F
L
S
I
W
G
TWT
I
IN
T
PV
D
AL
P
D
L
SD
V
Q
V
I
I
K
T
S
YPG
Q
A
P
Q
I
V
E
N
Q
VT
Y
PLT
TT
M
LS
V
P
G
AK
T
VRG
F
S
QF-
G
DSY
VYV
I
FE
D
GT
D
P
Y
W
A
RS
R
V
L
EY
L
N
Q
V
QGK
LP
A-----
GV
SAELGPDAT
GVG
W
I
YEY
A
LV
D
RSGKHDLA
D
L
R
S
L
Q
DWF
L
KYE
L
K
TIP
D
V
A
E
V
ASV
G
GVVKEY
QV
V
I
DP
QR
L
A
QYG
I
SLAE
V
KS
A
L
DAS
N
QEAGG
SSI
--
-
-
--ELAEAEYM
V
R
A
SGY
LQT
L
D
D
F
NH
I
V
L
KASE
N
G
VP
V
Y
L
R
DVA
K
I
Q
V
G
P
E
MRRGI
A
EL
N
--
G
E
V
V
G
GV
V
I
L
RS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSS
L
P
E
GV
E
IVTT
YD
RS
QL
I
DR
A
I
D
N
LSGK
L
L
E
EF
I
V
V
A
V
V
C
A
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
I
V
M
H
F
Q
G
L
N
A
N
I
MSL
G
G
I
A
I
A
V
G
A
M
VD
A
AIV
MI
EN
AH
K
R
L
E
E
WQHQHPDATL
D
NKT
R
WQ
V
IT
N
ASV
EVG
P
AL
FISLLI
I
T
LS
FIP
I
F
T
LE
G
QE
G
R
LFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------L
N
RF
L
IRV---
----
Y
HPLLL
KVL
HWPKTT
L
L
V
A
A
L
SVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TD
K
--
LIMSVPE
V
A
R
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMD
K
II
E
EL
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LST
G
IK
S
PIGIK
V
SGTVLADI
D
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
LE
GGRYIN
V
E
IN
RE
KA
A
R
Y
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DS
P
QA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YI
D
A
RDRD
M
V
S
V
V
HDLQKAIAEK
V
Q
LK
P
G
TSVA
F
S
G
--
-Q
FE
LL
E
RANHKLK
L
M
VP
M
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAI
E
AE
PSLNNPQTFSE
QKLD
EA
LHH
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
GAGS
E
VMSR
I
A
A
PM
I
GGM
IT
A
P
LL
S
L
F
II
P
AA
Y
K
L
M
WLHRHRVRK
fig|444452.5.peg.878
Escherichia coli O157:H7 str. EC4113
MIEWIIRR
S
VA
NRF
L
VLMG
A
L
F
L
S
I
W
G
TWT
I
IN
T
PV
D
AL
P
D
L
SD
V
Q
V
I
I
K
T
S
YPG
Q
A
P
Q
I
V
E
N
Q
VT
Y
PLT
TT
M
LS
V
P
G
AK
T
VRG
F
S
QF-
G
DSY
VYV
I
FE
D
GT
D
P
Y
W
A
RS
R
V
L
EY
L
N
Q
V
QGK
LP
A-----
GV
SAELGPDAT
GVG
W
I
YEY
A
LV
D
RSGKHDLA
D
L
R
S
L
Q
DWF
L
KYE
L
K
TIP
D
V
A
E
V
ASV
G
GVVKEY
QV
V
I
DP
QR
L
A
QYG
I
SLAE
V
KS
A
L
DAS
N
QEAGG
SSI
--
-
-
--ELAEAEYM
V
R
A
SGY
LQT
L
D
D
F
NH
I
V
L
KASE
N
G
VP
V
Y
L
R
DVA
K
I
Q
V
G
P
E
MRRGI
A
EL
N
--
G
E
V
V
G
GV
V
I
L
RS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSS
L
P
E
GV
E
IVTT
YD
RS
QL
I
DR
A
I
D
N
LSGK
L
L
E
EF
I
V
V
A
V
V
C
A
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
I
V
M
H
F
Q
G
L
N
A
N
I
MSL
G
G
I
A
I
A
V
G
A
M
VD
A
AIV
MI
EN
AH
K
R
L
E
E
WQHQHPDATL
D
NKT
R
WQ
V
IT
N
ASV
EVG
P
AL
FISLLI
I
T
LS
FIP
I
F
T
LE
G
QE
G
R
LFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------L
N
RF
L
IRV---
----
Y
HPLLL
KVL
HWPKTT
L
L
V
A
A
L
SVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TD
K
--
LIMSVPE
V
A
R
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMD
K
II
E
EL
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LST
G
IK
S
PIGIK
V
SGTVLADI
D
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
LE
GGRYIN
V
E
IN
RE
KA
A
R
Y
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DS
P
QA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YI
D
A
RDRD
M
V
S
V
V
HDLQKAIAEK
V
Q
LK
P
G
TSVA
F
S
G
--
-Q
FE
LL
E
RANHKLK
L
M
VP
M
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAI
E
AE
PSLNNPQTFSE
QKLD
EA
LHH
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
GAGS
E
VMSR
I
A
A
PM
I
GGM
IT
A
P
LL
S
L
F
II
P
AA
Y
K
L
M
WLHRHRVRK
fig|444450.8.peg.768
Escherichia coli O157:H7 str. EC4115
MIEWIIRR
S
VA
NRF
L
VLMG
A
L
F
L
S
I
W
G
TWT
I
IN
T
PV
D
AL
P
D
L
SD
V
Q
V
I
I
K
T
S
YPG
Q
A
P
Q
I
V
E
N
Q
VT
Y
PLT
TT
M
LS
V
P
G
AK
T
VRG
F
S
QF-
G
DSY
VYV
I
FE
D
GT
D
P
Y
W
A
RS
R
V
L
EY
L
N
Q
V
QGK
LP
A-----
GV
SAELGPDAT
GVG
W
I
YEY
A
LV
D
RSGKHDLA
D
L
R
S
L
Q
DWF
L
KYE
L
K
TIP
D
V
A
E
V
ASV
G
GVVKEY
QV
V
I
DP
QR
L
A
QYG
I
SLAE
V
KS
A
L
DAS
N
QEAGG
SSI
--
-
-
--ELAEAEYM
V
R
A
SGY
LQT
L
D
D
F
NH
I
V
L
KASE
N
G
VP
V
Y
L
R
DVA
K
I
Q
V
G
P
E
MRRGI
A
EL
N
--
G
E
V
V
G
GV
V
I
L
RS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSS
L
P
E
GV
E
IVTT
YD
RS
QL
I
DR
A
I
D
N
LSGK
L
L
E
EF
I
V
V
A
V
V
C
A
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
I
V
M
H
F
Q
G
L
N
A
N
I
MSL
G
G
I
A
I
A
V
G
A
M
VD
A
AIV
MI
EN
AH
K
R
L
E
E
WQHQHPDATL
D
NKT
R
WQ
V
IT
N
ASV
EVG
P
AL
FISLLI
I
T
LS
FIP
I
F
T
LE
G
QE
G
R
LFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------L
N
RF
L
IRV---
----
Y
HPLLL
KVL
HWPKTT
L
L
V
A
A
L
SVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TD
K
--
LIMSVPE
V
A
R
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMD
K
II
E
EL
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LST
G
IK
S
PIGIK
V
SGTVLADI
D
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
LE
GGRYIN
V
E
IN
RE
KA
A
R
Y
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DS
P
QA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YI
D
A
RDRD
M
V
S
V
V
HDLQKAIAEK
V
Q
LK
P
G
TSVA
F
S
G
--
-Q
FE
LL
E
RANHKLK
L
M
VP
M
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAI
E
AE
PSLNNPQTFSE
QKLD
EA
LHH
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
GAGS
E
VMSR
I
A
A
PM
I
GGM
IT
A
P
LL
S
L
F
II
P
AA
Y
K
L
M
WLHRHRVRK
fig|444451.5.peg.2270
Escherichia coli O157:H7 str. EC4196
MIEWIIRR
S
VA
NRF
L
VLMG
A
L
F
L
S
I
W
G
TWT
I
IN
T
PV
D
AL
P
D
L
SD
V
Q
V
I
I
K
T
S
YPG
Q
A
P
Q
I
V
E
N
Q
VT
Y
PLT
TT
M
LS
V
P
G
AK
T
VRG
F
S
QF-
G
DSY
VYV
I
FE
D
GT
D
P
Y
W
A
RS
R
V
L
EY
L
N
Q
V
QGK
LP
A-----
GV
SAELGPDAT
GVG
W
I
YEY
A
LV
D
RSGKHDLA
D
L
R
S
L
Q
DWF
L
KYE
L
K
TIP
D
V
A
E
V
ASV
G
GVVKEY
QV
V
I
DP
QR
L
A
QYG
I
SLAE
V
KS
A
L
DAS
N
QEAGG
SSI
--
-
-
--ELAEAEYM
V
R
A
SGY
LQT
L
D
D
F
NH
I
V
L
KASE
N
G
VP
V
Y
L
R
DVA
K
I
Q
V
G
P
E
MRRGI
A
EL
N
--
G
E
V
V
G
GV
V
I
L
RS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSS
L
P
E
GV
E
IVTT
YD
RS
QL
I
DR
A
I
D
N
LSGK
L
L
E
EF
I
V
V
A
V
V
C
A
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
I
V
M
H
F
Q
G
L
N
A
N
I
MSL
G
G
I
A
I
A
V
G
A
M
VD
A
AIV
MI
EN
AH
K
R
L
E
E
WQHQHPDATL
D
NKT
R
WQ
V
IT
N
ASV
EVG
P
AL
FISLLI
I
T
LS
FIP
I
F
T
LE
G
QE
G
R
LFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------L
N
RF
L
IRV---
----
Y
HPLLL
KVL
HWPKTT
L
L
V
A
A
L
SVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TD
K
--
LIMSVPE
V
A
R
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMD
K
II
E
EL
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LST
G
IK
S
PIGIK
V
SGTVLADI
D
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
LE
GGRYIN
V
E
IN
RE
KA
A
R
Y
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DS
P
QA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YI
D
A
RDRD
M
V
S
V
V
HDLQKAIAEK
V
Q
LK
P
G
TSVA
F
S
G
--
-Q
FE
LL
E
RANHKLK
L
M
VP
M
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAI
E
AE
PSLNNPQTFSE
QKLD
EA
LHH
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
GAGS
E
VMSR
I
A
A
PM
I
GGM
IT
A
P
LL
S
L
F
II
P
AA
Y
K
L
M
WLHRHRVRK
fig|444447.5.peg.3483
Escherichia coli O157:H7 str. EC4206
MIEWIIRR
S
VA
NRF
L
VLMG
A
L
F
L
S
I
W
G
TWT
I
IN
T
PV
D
AL
P
D
L
SD
V
Q
V
I
I
K
T
S
YPG
Q
A
P
Q
I
V
E
N
Q
VT
Y
PLT
TT
M
LS
V
P
G
AK
T
VRG
F
S
QF-
G
DSY
VYV
I
FE
D
GT
D
P
Y
W
A
RS
R
V
L
EY
L
N
Q
V
QGK
LP
A-----
GV
SAELGPDAT
GVG
W
I
YEY
A
LV
D
RSGKHDLA
D
L
R
S
L
Q
DWF
L
KYE
L
K
TIP
D
V
A
E
V
ASV
G
GVVKEY
QV
V
I
DP
QR
L
A
QYG
I
SLAE
V
KS
A
L
DAS
N
QEAGG
SSI
--
-
-
--ELAEAEYM
V
R
A
SGY
LQT
L
D
D
F
NH
I
V
L
KASE
N
G
VP
V
Y
L
R
DVA
K
I
Q
V
G
P
E
MRRGI
A
EL
N
--
G
E
V
V
G
GV
V
I
L
RS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSS
L
P
E
GV
E
IVTT
YD
RS
QL
I
DR
A
I
D
N
LSGK
L
L
E
EF
I
V
V
A
V
V
C
A
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
I
V
M
H
F
Q
G
L
N
A
N
I
MSL
G
G
I
A
I
A
V
G
A
M
VD
A
AIV
MI
EN
AH
K
R
L
E
E
WQHQHPDATL
D
NKT
R
WQ
V
IT
N
ASV
EVG
P
AL
FISLLI
I
T
LS
FIP
I
F
T
LE
G
QE
G
R
LFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------L
N
RF
L
IRV---
----
Y
HPLLL
KVL
HWPKTT
L
L
V
A
A
L
SVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TD
K
--
LIMSVPE
V
A
R
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMD
K
II
E
EL
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LST
G
IK
S
PIGIK
V
SGTVLADI
D
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
LE
GGRYIN
V
E
IN
RE
KA
A
R
Y
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DS
P
QA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YI
D
A
RDRD
M
V
S
V
V
HDLQKAIAEK
V
Q
LK
P
G
TSVA
F
S
G
--
-Q
FE
LL
E
RANHKLK
L
M
VP
M
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAI
E
AE
PSLNNPQTFSE
QKLD
EA
LHH
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
GAGS
E
VMSR
I
A
A
PM
I
GGM
IT
A
P
LL
S
L
F
II
P
AA
Y
K
L
M
WLHRHRVRK
fig|478004.5.peg.1476
Escherichia coli O157:H7 str. EC4401
MIEWIIRR
S
VA
NRF
L
VLMG
A
L
F
L
S
I
W
G
TWT
I
IN
T
PV
D
AL
P
D
L
SD
V
Q
V
I
I
K
T
S
YPG
Q
A
P
Q
I
V
E
N
Q
VT
Y
PLT
TT
M
LS
V
P
G
AK
T
VRG
F
S
QF-
G
DSY
VYV
I
FE
D
GT
D
P
Y
W
A
RS
R
V
L
EY
L
N
Q
V
QGK
LP
A-----
GV
SAELGPDAT
GVG
W
I
YEY
A
LV
D
RSGKHDLA
D
L
R
S
L
Q
DWF
L
KYE
L
K
TIP
D
V
A
E
V
ASV
G
GVVKEY
QV
V
I
DP
QR
L
A
QYG
I
SLAE
V
KS
A
L
DAS
N
QEAGG
SSI
--
-
-
--ELAEAEYM
V
R
A
SGY
LQT
L
D
D
F
NH
I
V
L
KASE
N
G
VP
V
Y
L
R
DVA
K
I
Q
V
G
P
E
MRRGI
A
EL
N
--
G
E
V
V
G
GV
V
I
L
RS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSS
L
P
E
GV
E
IVTT
YD
RS
QL
I
DR
A
I
D
N
LSGK
L
L
E
EF
I
V
V
A
V
V
C
A
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
I
V
M
H
F
Q
G
L
N
A
N
I
MSL
G
G
I
A
I
A
V
G
A
M
VD
A
AIV
MI
EN
AH
K
R
L
E
E
WQHQHPDATL
D
NKT
R
WQ
V
IT
N
ASV
EVG
P
AL
FISLLI
I
T
LS
FIP
I
F
T
LE
G
QE
G
R
LFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------L
N
RF
L
IRV---
----
Y
HPLLL
KVL
HWPKTT
L
L
V
A
A
L
SVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TD
K
--
LIMSVPE
V
A
R
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMD
K
II
E
EL
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LST
G
IK
S
PIGIK
V
SGTVLADI
D
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
LE
GGRYIN
V
E
IN
RE
KA
A
R
Y
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DS
P
QA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YI
D
A
RDRD
M
V
S
V
V
HDLQKAIAEK
V
Q
LK
P
G
TSVA
F
S
G
--
-Q
FE
LL
E
RANHKLK
L
M
VP
M
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAI
E
AE
PSLNNPQTFSE
QKLD
EA
LHH
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
GAGS
E
VMSR
I
A
A
PM
I
GGM
IT
A
P
LL
S
L
F
II
P
AA
Y
K
L
M
WLHRHRVRK
fig|478005.5.peg.3986
Escherichia coli O157:H7 str. EC4486
MIEWIIRR
S
VA
NRF
L
VLMG
A
L
F
L
S
I
W
G
TWT
I
IN
T
PV
D
AL
P
D
L
SD
V
Q
V
I
I
K
T
S
YPG
Q
A
P
Q
I
V
E
N
Q
VT
Y
PLT
TT
M
LS
V
P
G
AK
T
VRG
F
S
QF-
G
DSY
VYV
I
FE
D
GT
D
P
Y
W
A
RS
R
V
L
EY
L
N
Q
V
QGK
LP
A-----
GV
SAELGPDAT
GVG
W
I
YEY
A
LV
D
RSGKHDLA
D
L
R
S
L
Q
DWF
L
KYE
L
K
TIP
D
V
A
E
V
ASV
G
GVVKEY
QV
V
I
DP
QR
L
A
QYG
I
SLAE
V
KS
A
L
DAS
N
QEAGG
SSI
--
-
-
--ELAEAEYM
V
R
A
SGY
LQT
L
D
D
F
NH
I
V
L
KASE
N
G
VP
V
Y
L
R
DVA
K
I
Q
V
G
P
E
MRRGI
A
EL
N
--
G
E
V
V
G
GV
V
I
L
RS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSS
L
P
E
GV
E
IVTT
YD
RS
QL
I
DR
A
I
D
N
LSGK
L
L
E
EF
I
V
V
A
V
V
C
A
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
I
V
M
H
F
Q
G
L
N
A
N
I
MSL
G
G
I
A
I
A
V
G
A
M
VD
A
AIV
MI
EN
AH
K
R
L
E
E
WQHQHPDATL
D
NKT
R
WQ
V
IT
N
ASV
EVG
P
AL
FISLLI
I
T
LS
FIP
I
F
T
LE
G
QE
G
R
LFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------L
N
RF
L
IRV---
----
Y
HPLLL
KVL
HWPKTT
L
L
V
A
A
L
SVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TD
K
--
LIMSVPE
V
A
R
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMD
K
II
E
EL
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LST
G
IK
S
PIGIK
V
SGTVLADI
D
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
LE
GGRYIN
V
E
IN
RE
KA
A
R
Y
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DS
P
QA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YI
D
A
RDRD
M
V
S
V
V
HDLQKAIAEK
V
Q
LK
P
G
TSVA
F
S
G
--
-Q
FE
LL
E
RANHKLK
L
M
VP
M
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAI
E
AE
PSLNNPQTFSE
QKLD
EA
LHH
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
GAGS
E
VMSR
I
A
A
PM
I
GGM
IT
A
P
LL
S
L
F
II
P
AA
Y
K
L
M
WLHRHRVRK
fig|478006.5.peg.835
Escherichia coli O157:H7 str. EC4501
MIEWIIRR
S
VA
NRF
L
VLMG
A
L
F
L
S
I
W
G
TWT
I
IN
T
PV
D
AL
P
D
L
SD
V
Q
V
I
I
K
T
S
YPG
Q
A
P
Q
I
V
E
N
Q
VT
Y
PLT
TT
M
LS
V
P
G
AK
T
VRG
F
S
QF-
G
DSY
VYV
I
FE
D
GT
D
P
Y
W
A
RS
R
V
L
EY
L
N
Q
V
QGK
LP
A-----
GV
SAELGPDAT
GVG
W
I
YEY
A
LV
D
RSGKHDLA
D
L
R
S
L
Q
DWF
L
KYE
L
K
TIP
D
V
A
E
V
ASV
G
GVVKEY
QV
V
I
DP
QR
L
A
QYG
I
SLAE
V
KS
A
L
DAS
N
QEAGG
SSI
--
-
-
--ELAEAEYM
V
R
A
SGY
LQT
L
D
D
F
NH
I
V
L
KASE
N
G
VP
V
Y
L
R
DVA
K
I
Q
V
G
P
E
MRRGI
A
EL
N
--
G
E
V
V
G
GV
V
I
L
RS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSS
L
P
E
GV
E
IVTT
YD
RS
QL
I
DR
A
I
D
N
LSGK
L
L
E
EF
I
V
V
A
V
V
C
A
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
I
V
M
H
F
Q
G
L
N
A
N
I
MSL
G
G
I
A
I
A
V
G
A
M
VD
A
AIV
MI
EN
AH
K
R
L
E
E
WQHQHPDATL
D
NKT
R
WQ
V
IT
N
ASV
EVG
P
AL
FISLLI
I
T
LS
FIP
I
F
T
LE
G
QE
G
R
LFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------L
N
RF
L
IRV---
----
Y
HPLLL
KVL
HWPKTT
L
L
V
A
A
L
SVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TD
K
--
LIMSVPE
V
A
R
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMD
K
II
E
EL
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LST
G
IK
S
PIGIK
V
SGTVLADI
D
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
LE
GGRYIN
V
E
IN
RE
KA
A
R
Y
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DS
P
QA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YI
D
A
RDRD
M
V
S
V
V
HDLQKAIAEK
V
Q
LK
P
G
TSVA
F
S
G
--
-Q
FE
LL
E
RANHKLK
L
M
VP
M
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAI
E
AE
PSLNNPQTFSE
QKLD
EA
LHH
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
GAGS
E
VMSR
I
A
A
PM
I
GGM
IT
A
P
LL
S
L
F
II
P
AA
Y
K
L
M
WLHRHRVRK
fig|478007.5.peg.967
Escherichia coli O157:H7 str. EC508
MIEWIIRR
S
VA
NRF
L
VLMG
A
L
F
L
S
I
W
G
TWT
I
IN
T
PV
D
AL
P
D
L
SD
V
Q
V
I
I
K
T
S
YPG
Q
A
P
Q
I
V
E
N
Q
VT
Y
PLT
TT
M
LS
V
P
G
AK
T
VRG
F
S
QF-
G
DSY
VYV
I
FE
D
GT
D
P
Y
W
A
RS
R
V
L
EY
L
N
Q
V
QGK
LP
A-----
GV
SAELGPDAT
GVG
W
I
YEY
A
LV
D
RSGKHDLA
D
L
R
S
L
Q
DWF
L
KYE
L
K
TIP
D
V
A
E
V
ASV
G
GVVKEY
QV
V
I
DP
QR
L
A
QYG
I
SLAE
V
KS
A
L
DAS
N
QEAGG
SSI
--
-
-
--ELAEAEYM
V
R
A
SGY
LQT
L
D
D
F
NH
I
V
L
KASE
N
G
VP
V
Y
L
R
DVA
K
I
Q
V
G
P
E
MRRGI
A
EL
N
--
G
E
V
V
G
GV
V
I
L
RS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSS
L
P
E
GV
E
IVTT
YD
RS
QL
I
DR
A
I
D
N
LSGK
L
L
E
EF
I
V
V
A
V
V
C
A
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
I
V
M
H
F
Q
G
L
N
A
N
I
MSL
G
G
I
A
I
A
V
G
A
M
VD
A
AIV
MI
EN
AH
K
R
L
E
E
WQHQHPDATL
D
NKT
R
WQ
V
IT
N
ASV
EVG
P
AL
FISLLI
I
T
LS
FIP
I
F
T
LE
G
QE
G
R
LFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------L
N
RF
L
IRV---
----
Y
HPLLL
KVL
HWPKTT
L
L
V
A
A
L
SVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TD
K
--
LIMSVPE
V
A
R
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMD
K
II
E
EL
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LST
G
IK
S
PIGIK
V
SGTVLADI
D
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
LE
GGRYIN
V
E
IN
RE
KA
A
R
Y
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DS
P
QA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YI
D
A
RDRD
M
V
S
V
V
HDLQKAIAEK
V
Q
LK
P
G
TSVA
F
S
G
--
-Q
FE
LL
E
RANHKLK
L
M
VP
M
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAI
E
AE
PSLNNPQTFSE
QKLD
EA
LHH
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
GAGS
E
VMSR
I
A
A
PM
I
GGM
IT
A
P
LL
S
L
F
II
P
AA
Y
K
L
M
WLHRHRVRK
fig|478008.5.peg.1710
Escherichia coli O157:H7 str. EC869
MIEWIIRR
S
VA
NRF
L
VLMG
A
L
F
L
S
I
W
G
TWT
I
IN
T
PV
D
AL
P
D
L
SD
V
Q
V
I
I
K
T
S
YPG
Q
A
P
Q
I
V
E
N
Q
VT
Y
PLT
TT
M
LS
V
P
G
AK
T
VRG
F
S
QF-
G
DSY
VYV
I
FE
D
GT
D
P
Y
W
A
RS
R
V
L
EY
L
N
Q
V
QGK
LP
A-----
GV
SAELGPDAT
GVG
W
I
YEY
A
LV
D
RSGKHDLA
D
L
R
S
L
Q
DWF
L
KYE
L
K
TIP
D
V
A
E
V
ASV
G
GVVKEY
QV
V
I
DP
QR
L
A
QYG
I
SLAE
V
KS
A
L
DAS
N
QEAGG
SSI
--
-
-
--ELAEAEYM
V
R
A
SGY
LQT
L
D
D
F
NH
I
V
L
KASE
N
G
VP
V
Y
L
R
DVA
K
I
Q
V
G
P
E
MRRGI
A
EL
N
--
G
E
V
V
G
GV
V
I
L
RS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSS
L
P
E
GV
E
IVTT
YD
RS
QL
I
DR
A
I
D
N
LSGK
L
L
E
EF
I
V
V
A
V
V
C
A
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
I
V
M
H
F
Q
G
L
N
A
N
I
MSL
G
G
I
A
I
A
V
G
A
M
VD
A
AIV
MI
EN
AH
K
R
L
E
E
WQHQHPDATL
D
NKT
R
WQ
V
IT
N
ASV
EVG
P
AL
FISLLI
I
T
LS
FIP
I
F
T
LE
G
QE
G
R
LFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------L
N
RF
L
IRV---
----
Y
HPLLL
KVL
HWPKTT
L
L
V
A
A
L
SVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TD
K
--
LIMSVPE
V
A
R
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMD
K
II
E
EL
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LST
G
IK
S
PIGIK
V
SGTVLADI
D
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
LE
GGRYIN
V
E
IN
RE
KA
A
R
Y
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DS
P
QA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YI
D
A
RDRD
M
V
S
V
V
HDLQKAIAEK
V
Q
LK
P
G
TSVA
F
S
G
--
-Q
FE
LL
E
RANHKLK
L
M
VP
M
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAI
E
AE
PSLNNPQTFSE
QKLD
EA
LHH
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
GAGS
E
VMSR
I
A
A
PM
I
GGM
IT
A
P
LL
S
L
F
II
P
AA
Y
K
L
M
WLHRHRVRK
fig|637388.3.peg.1105
Escherichia coli O157:H7 str. FRIK2000
MIEWIIRR
S
VA
NRF
L
VLMG
A
L
F
L
S
I
W
G
TWT
I
IN
T
PV
D
AL
P
D
L
SD
V
Q
V
I
I
K
T
S
YPG
Q
A
P
Q
I
V
E
N
Q
VT
Y
PLT
TT
M
LS
V
P
G
AK
T
VRG
F
S
QF-
G
DSY
VYV
I
FE
D
GT
D
P
Y
W
A
RS
R
V
L
EY
L
N
Q
V
QGK
LP
A-----
GV
SAELGPDAT
GVG
W
I
YEY
A
LV
D
RSGKHDLA
D
L
R
S
L
Q
DWF
L
KYE
L
K
TIP
D
V
A
E
V
ASV
G
GVVKEY
QV
V
I
DP
QR
L
A
QYG
I
SLAE
V
KS
A
L
DAS
N
QEAGG
SSI
--
-
-
--ELAEAEYM
V
R
A
SGY
LQT
L
D
D
F
NH
I
V
L
KASE
N
G
VP
V
Y
L
R
DVA
K
I
Q
V
G
P
E
MRRGI
A
EL
N
--
G
E
V
V
G
GV
V
I
L
RS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSS
L
P
E
GV
E
IVTT
YD
RS
QL
I
DR
A
I
D
N
LSGK
L
L
E
EF
I
V
V
A
V
V
C
A
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
I
V
M
H
F
Q
G
L
N
A
N
I
MSL
G
G
I
A
I
A
V
G
A
M
VD
A
AIV
MI
EN
AH
K
R
L
E
E
WQHQHPDATL
D
NKT
R
WQ
V
IT
N
ASV
EVG
P
AL
FISLLI
I
T
LS
FIP
I
F
T
LE
G
QE
G
R
LFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------L
N
RF
L
IRV---
----
Y
HPLLL
KVL
HWPKTT
L
L
V
A
A
L
SVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TD
K
--
LIMSVPE
V
A
R
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMD
K
II
E
EL
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LST
G
IK
S
PIGIK
V
SGTVLADI
D
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
LE
GGRYIN
V
E
IN
RE
KA
A
R
Y
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DS
P
QA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YI
D
A
RDRD
M
V
S
V
V
HDLQKAIAEK
V
Q
LK
P
G
TSVA
F
S
G
--
-Q
FE
LL
E
RANHKLK
L
M
VP
M
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAI
E
AE
PSLNNPQTFSE
QKLD
EA
LHH
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
GAGS
E
VMSR
I
A
A
PM
I
GGM
IT
A
P
LL
S
L
F
II
P
AA
Y
K
L
M
WLHRHRVRK
fig|570506.3.peg.3642
Escherichia coli O157:H7 str. FRIK966
MIEWIIRR
S
VA
NRF
L
VLMG
A
L
F
L
S
I
W
G
TWT
I
IN
T
PV
D
AL
P
D
L
SD
V
Q
V
I
I
K
T
S
YPG
Q
A
P
Q
I
V
E
N
Q
VT
Y
PLT
TT
M
LS
V
P
G
AK
T
VRG
F
S
QF-
G
DSY
VYV
I
FE
D
GT
D
P
Y
W
A
RS
R
V
L
EY
L
N
Q
V
QGK
LP
A-----
GV
SAELGPDAT
GVG
W
I
YEY
A
LV
D
RSGKHDLA
D
L
R
S
L
Q
DWF
L
KYE
L
K
TIP
D
V
A
E
V
ASV
G
GVVKEY
QV
V
I
DP
QR
L
A
QYG
I
SLAE
V
KS
A
L
DAS
N
QEAGG
SSI
--
-
-
--ELAEAEYM
V
R
A
SGY
LQT
L
D
D
F
NH
I
V
L
KASE
N
G
VP
V
Y
L
R
DVA
K
I
Q
V
G
P
E
MRRGI
A
EL
N
--
G
E
V
V
G
GV
V
I
L
RS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSS
L
P
E
GV
E
IVTT
YD
RS
QL
I
DR
A
I
D
N
LSGK
L
L
E
EF
I
V
V
A
V
V
C
A
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
I
V
M
H
F
Q
G
L
N
A
N
I
MSL
G
G
I
A
I
A
V
G
A
M
VD
A
AIV
MI
EN
AH
K
R
L
E
E
WQHQHPDATL
D
NKT
R
WQ
V
IT
N
ASV
EVG
P
AL
FISLLI
I
T
LS
FIP
I
F
T
LE
G
QE
G
R
LFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------L
N
RF
L
IRV---
----
Y
HPLLL
KVL
HWPKTT
L
L
V
A
A
L
SVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TD
K
--
LIMSVPE
V
A
R
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMD
K
II
E
EL
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LST
G
IK
S
PIGIK
V
SGTVLADI
D
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
LE
GGRYIN
V
E
IN
RE
KA
A
R
Y
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DS
P
QA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YI
D
A
RDRD
M
V
S
V
V
HDLQKAIAEK
V
Q
LK
P
G
TSVA
F
S
G
--
-Q
FE
LL
E
RANHKLK
L
M
VP
M
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAI
E
AE
PSLNNPQTFSE
QKLD
EA
LHH
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
GAGS
E
VMSR
I
A
A
PM
I
GGM
IT
A
P
LL
S
L
F
II
P
AA
Y
K
L
M
WLHRHRVRK
fig|386585.9.peg.721
Escherichia coli O157:H7 str. Sakai
MIEWIIRR
S
VA
NRF
L
VLMG
A
L
F
L
S
I
W
G
TWT
I
IN
T
PV
D
AL
P
D
L
SD
V
Q
V
I
I
K
T
S
YPG
Q
A
P
Q
I
V
E
N
Q
VT
Y
PLT
TT
M
LS
V
P
G
AK
T
VRG
F
S
QF-
G
DSY
VYV
I
FE
D
GT
D
P
Y
W
A
RS
R
V
L
EY
L
N
Q
V
QGK
LP
A-----
GV
SAELGPDAT
GVG
W
I
YEY
A
LV
D
RSGKHDLA
D
L
R
S
L
Q
DWF
L
KYE
L
K
TIP
D
V
A
E
V
ASV
G
GVVKEY
QV
V
I
DP
QR
L
A
QYG
I
SLAE
V
KS
A
L
DAS
N
QEAGG
SSI
--
-
-
--ELAEAEYM
V
R
A
SGY
LQT
L
D
D
F
NH
I
V
L
KASE
N
G
VP
V
Y
L
R
DVA
K
I
Q
V
G
P
E
MRRGI
A
EL
N
--
G
E
V
V
G
GV
V
I
L
RS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSS
L
P
E
GV
E
IVTT
YD
RS
QL
I
DR
A
I
D
N
LSGK
L
L
E
EF
I
V
V
A
V
V
C
A
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
I
V
M
H
F
Q
G
L
N
A
N
I
MSL
G
G
I
A
I
A
V
G
A
M
VD
A
AIV
MI
EN
AH
K
R
L
E
E
WQHQHPDATL
D
NKT
R
WQ
V
IT
N
ASV
EVG
P
AL
FISLLI
I
T
LS
FIP
I
F
T
LE
G
QE
G
R
LFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------L
N
RF
L
IRV---
----
Y
HPLLL
KVL
HWPKTT
L
L
V
A
A
L
SVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TD
K
--
LIMSVPE
V
A
R
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMD
K
II
E
EL
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LST
G
IK
S
PIGIK
V
SGTVLADI
D
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
LE
GGRYIN
V
E
IN
RE
KA
A
R
Y
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DS
P
QA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YI
D
A
RDRD
M
V
S
V
V
HDLQKAIAEK
V
Q
LK
P
G
TSVA
F
S
G
--
-Q
FE
LL
E
RANHKLK
L
M
VP
M
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAI
E
AE
PSLNNPQTFSE
QKLD
EA
LHH
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
GAGS
E
VMSR
I
A
A
PM
I
GGM
IT
A
P
LL
S
L
F
II
P
AA
Y
K
L
M
WLHRHRVRK
fig|544404.4.peg.633
Escherichia coli O157:H7 str. TW14359
MIEWIIRR
S
VA
NRF
L
VLMG
A
L
F
L
S
I
W
G
TWT
I
IN
T
PV
D
AL
P
D
L
SD
V
Q
V
I
I
K
T
S
YPG
Q
A
P
Q
I
V
E
N
Q
VT
Y
PLT
TT
M
LS
V
P
G
AK
T
VRG
F
S
QF-
G
DSY
VYV
I
FE
D
GT
D
P
Y
W
A
RS
R
V
L
EY
L
N
Q
V
QGK
LP
A-----
GV
SAELGPDAT
GVG
W
I
YEY
A
LV
D
RSGKHDLA
D
L
R
S
L
Q
DWF
L
KYE
L
K
TIP
D
V
A
E
V
ASV
G
GVVKEY
QV
V
I
DP
QR
L
A
QYG
I
SLAE
V
KS
A
L
DAS
N
QEAGG
SSI
--
-
-
--ELAEAEYM
V
R
A
SGY
LQT
L
D
D
F
NH
I
V
L
KASE
N
G
VP
V
Y
L
R
DVA
K
I
Q
V
G
P
E
MRRGI
A
EL
N
--
G
E
V
V
G
GV
V
I
L
RS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSS
L
P
E
GV
E
IVTT
YD
RS
QL
I
DR
A
I
D
N
LSGK
L
L
E
EF
I
V
V
A
V
V
C
A
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
I
V
M
H
F
Q
G
L
N
A
N
I
MSL
G
G
I
A
I
A
V
G
A
M
VD
A
AIV
MI
EN
AH
K
R
L
E
E
WQHQHPDATL
D
NKT
R
WQ
V
IT
N
ASV
EVG
P
AL
FISLLI
I
T
LS
FIP
I
F
T
LE
G
QE
G
R
LFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------L
N
RF
L
IRV---
----
Y
HPLLL
KVL
HWPKTT
L
L
V
A
A
L
SVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TD
K
--
LIMSVPE
V
A
R
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMD
K
II
E
EL
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LST
G
IK
S
PIGIK
V
SGTVLADI
D
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
LE
GGRYIN
V
E
IN
RE
KA
A
R
Y
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DS
P
QA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YI
D
A
RDRD
M
V
S
V
V
HDLQKAIAEK
V
Q
LK
P
G
TSVA
F
S
G
--
-Q
FE
LL
E
RANHKLK
L
M
VP
M
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAI
E
AE
PSLNNPQTFSE
QKLD
EA
LHH
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
GAGS
E
VMSR
I
A
A
PM
I
GGM
IT
A
P
LL
S
L
F
II
P
AA
Y
K
L
M
WLHRHRVRK
fig|502346.5.peg.588
Escherichia coli O157:H7 str. TW14588
MIEWIIRR
S
VA
NRF
L
VLMG
A
L
F
L
S
I
W
G
TWT
I
IN
T
PV
D
AL
P
D
L
SD
V
Q
V
I
I
K
T
S
YPG
Q
A
P
Q
I
V
E
N
Q
VT
Y
PLT
TT
M
LS
V
P
G
AK
T
VRG
F
S
QF-
G
DSY
VYV
I
FE
D
GT
D
P
Y
W
A
RS
R
V
L
EY
L
N
Q
V
QGK
LP
A-----
GV
SAELGPDAT
GVG
W
I
YEY
A
LV
D
RSGKHDLA
D
L
R
S
L
Q
DWF
L
KYE
L
K
TIP
D
V
A
E
V
ASV
G
GVVKEY
QV
V
I
DP
QR
L
A
QYG
I
SLAE
V
KS
A
L
DAS
N
QEAGG
SSI
--
-
-
--ELAEAEYM
V
R
A
SGY
LQT
L
D
D
F
NH
I
V
L
KASE
N
G
VP
V
Y
L
R
DVA
K
I
Q
V
G
P
E
MRRGI
A
EL
N
--
G
E
V
V
G
GV
V
I
L
RS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSS
L
P
E
GV
E
IVTT
YD
RS
QL
I
DR
A
I
D
N
LSGK
L
L
E
EF
I
V
V
A
V
V
C
A
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
I
V
M
H
F
Q
G
L
N
A
N
I
MSL
G
G
I
A
I
A
V
G
A
M
VD
A
AIV
MI
EN
AH
K
R
L
E
E
WQHQHPDATL
D
NKT
R
WQ
V
IT
N
ASV
EVG
P
AL
FISLLI
I
T
LS
FIP
I
F
T
LE
G
QE
G
R
LFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------L
N
RF
L
IRV---
----
Y
HPLLL
KVL
HWPKTT
L
L
V
A
A
L
SVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TD
K
--
LIMSVPE
V
A
R
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMD
K
II
E
EL
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LST
G
IK
S
PIGIK
V
SGTVLADI
D
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
LE
GGRYIN
V
E
IN
RE
KA
A
R
Y
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DS
P
QA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YI
D
A
RDRD
M
V
S
V
V
HDLQKAIAEK
V
Q
LK
P
G
TSVA
F
S
G
--
-Q
FE
LL
E
RANHKLK
L
M
VP
M
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAI
E
AE
PSLNNPQTFSE
QKLD
EA
LHH
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
GAGS
E
VMSR
I
A
A
PM
I
GGM
IT
A
P
LL
S
L
F
II
P
AA
Y
K
L
M
WLHRHRVRK
fig|701177.3.peg.733
Escherichia coli O55:H7 str. CB9615
MIEWIIRR
S
VA
NRF
L
VLMG
A
L
F
L
S
I
W
G
TWT
I
IN
T
PV
D
AL
P
D
L
SD
V
Q
V
I
I
K
T
S
YPG
Q
A
P
Q
I
V
E
N
Q
VT
Y
PLT
TT
M
LS
V
P
G
AK
T
VRG
F
S
QF-
G
DSY
VYV
I
FE
D
GT
D
P
Y
W
A
RS
R
V
L
EY
L
N
Q
V
QGK
LP
A-----
GV
SAELGPDAT
GVG
W
I
YEY
A
LV
D
RSGKHDLA
D
L
R
S
L
Q
DWF
L
KYE
L
K
TIP
D
V
A
E
V
ASV
G
GVVKEY
QV
V
I
DP
QR
L
A
QYG
I
SLAE
V
KS
A
L
DAS
N
QEAGG
SSI
--
-
-
--ELAEAEYM
V
R
A
SGY
LQT
L
D
G
F
NH
I
V
L
KASE
N
G
VP
V
Y
L
R
DVA
K
I
Q
V
G
P
E
MRRGI
A
EL
NG
E
G
E
V
V
G
GV
V
I
L
RS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSS
L
P
E
GV
E
IVTT
YD
RS
QL
I
DR
A
I
D
N
LSGK
L
L
E
EF
I
V
V
A
V
V
C
A
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
I
V
M
H
F
Q
G
L
N
A
N
I
MSL
G
G
I
A
I
A
V
G
A
M
VD
A
AIV
MI
EN
AH
K
R
L
E
E
WQHQHPDATL
D
NKT
R
WQ
V
IT
N
ASV
EVG
P
AL
FISLLI
I
T
LS
FIP
I
F
T
LE
G
QE
G
R
LFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------L
N
RF
L
IRV---
----
Y
HPLLL
KVL
HWPKTT
L
L
V
A
A
L
SVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TD
K
--
LIMSVPE
V
A
R
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMD
K
II
E
EL
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LST
G
IK
S
PIGIK
V
SGTVLADI
D
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
LE
GGRYIN
V
E
IN
RE
KA
A
G
Y
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DS
P
QA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YI
D
A
RDRD
M
V
S
V
V
HDLQKAIAEK
V
Q
LK
P
G
TSVA
F
S
G
--
-Q
FE
LL
E
RANHKLK
L
M
VP
M
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAI
E
AE
PSLNNPQTFSE
QKLD
EA
LYH
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
GAGS
E
VMSR
I
A
A
PM
I
GGM
IT
A
P
LL
S
L
F
II
P
AA
Y
K
L
M
WLHRHRVRK
fig|749537.3.peg.100
Escherichia coli MS 115-1 (1-1044/1048)
MIEWIIRR
S
VA
NRF
L
V
M
MG
A
L
F
L
S
I
W
G
TWT
I
IN
T
PV
D
AL
P
D
L
SD
V
Q
V
I
I
K
T
S
YPG
Q
A
P
Q
I
V
E
N
Q
VT
Y
PLT
TT
M
LS
V
P
G
AK
T
VRG
F
S
QF-
G
DSY
VYV
I
FE
D
GT
D
LY
W
A
RS
R
V
L
EY
L
N
Q
V
QGK
LP
A-----
GV
SSEIGPDAT
GVG
W
I
FEY
A
LV
D
RSGKHDLS
EL
R
S
L
Q
DWF
L
KFE
L
K
TIP
N
V
A
E
V
ASV
G
GVVKQY
Q
I
Q
V
N
P
VK
L
S
QYG
I
SLPE
V
KQ
A
L
ESS
N
QEAGG
SS
V
--
-
-
--EMAEAEYM
V
R
A
SGY
LQ
S
I
D
D
F
NN
I
V
L
KTGE
N
G
VP
V
Y
L
R
DVA
R
V
Q
T
G
P
E
MRRGI
A
EL
NG
Q
G
E
V
A
G
GV
V
I
L
RS
G
K
N
ARD
V
ITA
V
RDK
L
ET
L
KAS
L
P
E
GV
E
IVTT
YD
RS
QL
I
DR
A
I
D
N
LSSK
L
L
E
EF
I
V
V
A
I
V
C
A
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
I
V
M
H
F
Q
G
L
N
A
N
I
MSL
G
G
I
A
I
A
V
G
A
M
VD
A
AIV
MI
EN
AH
K
R
L
E
E
W
D
HQHP
GEQI
D
NAT
R
WK
V
IT
D
ASV
EVG
P
AL
FISLLI
I
T
LS
FIP
I
F
T
LE
G
QE
G
R
LFG
P
LAF
T
KTY
S
M
AG
AA
A
L
A
I
I
VI
P
I
L
MG
FW
I
RGKIPAETSNP------L
N
RV
L
IKA---
----
Y
HPLLL
R
VL
HWPKTT
L
L
V
A
A
L
SIFTVIW
P
LSQV
G
GE
FLP
KI
N
E
G
DLLYMP
S
T
L
P
G
V
S
PAEAAALLQ
T
TD
K
--
LIKSVPE
V
A
SVF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
ED
QW
R
PG--MTID
K
II
E
EL
DRTVRLPGLAN
L
WVP
P
I
R
NRID
M
LST
G
IK
S
PIGIK
V
SGTVLSDI
D
V
T
AQ---
S
I
EAV
A
KTV
P
-G
V
VS
A
LA
E
R
LE
GGRYID
V
D
IN
RE
KA
S
R
Y
G
MTV
G
D
V
QLF
V
S
S
A
I
G
GAM
V
GETVEGVAR
Y
P
I
N
IR
YPQDY
R
NS
P
QA
L
REMP
I
L
T
PM
K
QQI
T
L
G
DV
A
DIKVVS
G
P
TM
L
KTE
N
AR
P
ASW
I
YV
D
A
RGRD
M
V
S
V
V
NDIKTAISEK
V
K
L
R
P
G
TSVA
F
S
G
--
-Q
FE
LL
E
HANKKLK
L
M
VP
M
T
V
M
I
I
F
I
L
L
YL
AFRR
VDE
A
LL
I
LM
S
L
P
F
A
L
VG
G
IW
F
LYWQ
G
FH
M
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAI
E
AH
P
E
L
SRKE
TF
TP
EGLD
EA
LYH
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
GAGS
E
VMSR
I
A
A
PM
I
GGM
IT
A
P
LL
S
L
F
II
P
AA
Y
K
L
I
WL
R
K
H
K
fig|6666666.5357.peg.3438
Escherichia coli TY-2482 (1-1044/1048)
MIEWIIRR
S
VA
NRF
L
V
M
MG
A
L
F
L
S
I
W
G
TWT
I
IN
T
PV
D
AL
P
D
L
SD
V
Q
V
I
I
K
T
S
YPG
Q
A
P
Q
I
V
E
N
Q
VT
Y
PLT
TT
M
LS
V
P
G
AK
T
VRG
F
S
QF-
G
DSY
VYV
I
FE
D
GT
D
LY
W
A
RS
R
V
L
EY
L
N
Q
V
QGK
LP
A-----
GV
SSEIGPDAT
GVG
W
I
FEY
A
LV
D
RSGKHDLS
EL
R
S
L
Q
DWF
L
KFE
L
K
TIP
N
V
A
E
V
ASV
G
GVVKQY
Q
I
Q
V
N
P
VK
L
S
QYG
I
SLPE
V
KQ
A
L
ESS
N
QEAGG
SS
V
--
-
-
--EMAEAEYM
V
R
A
SGY
LQ
S
I
D
D
F
NN
I
V
L
KTGE
N
G
VP
V
Y
L
R
DVA
R
V
Q
T
G
P
E
MRRGI
A
EL
NG
Q
G
E
V
A
G
GV
V
I
L
RS
G
K
N
ARD
V
ITA
V
RDK
L
ET
L
KAS
L
P
E
GV
E
IVTT
YD
RS
QL
I
DR
A
I
D
N
LSSK
L
L
E
EF
I
V
V
A
I
V
C
A
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
I
V
M
H
F
Q
G
L
N
A
N
I
MSL
G
G
I
A
I
A
V
G
A
M
VD
A
AIV
MI
EN
AH
K
R
L
E
E
W
D
HQHP
GEQI
D
NAT
R
WK
V
IT
D
ASV
EVG
P
AL
FISLLI
I
T
LS
FIP
I
F
T
LE
G
QE
G
R
LFG
P
LAF
T
KTY
S
M
AG
AA
A
L
A
I
I
VI
P
I
L
MG
FW
I
RGKIPAETSNP------L
N
RV
L
IKA---
----
Y
HPLLL
R
VL
HWPKTT
L
L
V
A
A
L
SIFTVIW
P
LSQV
G
GE
FLP
KI
N
E
G
DLLYMP
S
T
L
P
G
V
S
PAEAAALLQ
T
TD
K
--
LIKSVPE
V
A
SVF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
ED
QW
R
PG--MTID
K
II
E
EL
DRTVRLPGLAN
L
WVP
P
I
R
NRID
M
LST
G
IK
S
PIGIK
V
SGTVLSDI
D
A
T
AQ---
S
I
EAV
A
KTV
P
-G
V
VS
A
LA
E
R
LE
GGRYID
V
D
IN
RE
KA
S
R
Y
G
MTV
G
D
V
QLF
I
S
S
A
I
G
GAT
V
GETVEGVAR
Y
P
I
N
IR
YPQDY
R
NS
P
QA
L
KQMP
I
L
T
PM
K
QQI
T
L
G
DV
A
DIKVVS
G
P
TM
L
KTE
N
AR
P
ASW
I
YI
D
A
RGRD
M
V
S
V
V
NDIKTAISQK
V
K
L
R
P
G
TSVS
F
S
G
--
-Q
FE
LL
E
HANKKLK
L
M
VP
M
T
V
M
I
I
F
I
L
L
YL
AFRR
VDE
A
LL
I
LM
S
L
P
F
A
L
VG
G
IW
F
LYWQ
G
FH
M
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAI
E
AH
P
E
L
SRKE
TF
TP
EGLD
EA
LYH
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
GAGS
E
VMSR
I
A
A
PM
I
GGM
IT
A
P
LL
S
L
F
II
P
AA
Y
K
L
I
WL
R
RH
K
fig|585055.6.peg.3944
Escherichia coli 55989 (1-1044/1048)
MIEWIIRR
S
VA
NRF
L
V
M
MG
A
L
F
L
S
I
W
G
TWT
I
IN
T
PV
D
AL
P
D
L
SD
V
Q
V
I
I
K
T
S
YPG
Q
A
P
Q
I
V
E
N
Q
VT
Y
PLT
TT
M
LS
V
P
G
AK
T
VRG
F
S
QF-
G
DSY
VYV
I
FE
D
GT
D
LY
W
A
RS
R
V
L
EY
L
N
Q
V
QGK
LP
A-----
GV
SSEIGPDAT
GVG
W
I
FEY
A
LV
D
RSGKHDLS
EL
R
S
L
Q
DWF
L
KFE
L
K
TIP
N
V
A
E
V
ASV
G
GVVKQY
Q
I
Q
V
N
P
VK
L
S
QYG
I
SLPE
V
KQ
A
L
ESS
N
QEAGG
SS
V
--
-
-
--EMAEAEYM
V
R
A
SGY
LQ
S
I
D
D
F
NN
I
V
L
KTGE
N
G
VP
V
Y
L
R
DVA
R
V
Q
T
G
P
E
MRRGI
A
EL
NG
Q
G
E
V
A
G
GV
V
I
L
RS
G
K
N
ARD
V
ITA
V
RDK
L
ET
L
KAS
L
P
E
GV
E
IVTT
YD
RS
QL
I
DR
A
I
D
N
LSSK
L
L
E
EF
I
V
V
A
I
V
C
A
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
I
V
M
H
F
Q
G
L
N
A
N
I
MSL
G
G
I
A
I
A
V
G
A
M
VD
A
AIV
MI
EN
AH
K
R
L
E
E
W
D
HQHP
GEQI
D
NAT
R
WK
V
IT
D
ASV
EVG
P
AL
FISLLI
I
T
LS
FIP
I
F
T
LE
G
QE
G
R
LFG
P
LAF
T
KTY
S
M
AG
AA
A
L
A
I
I
VI
P
I
L
MG
FW
I
RGKIPAETSNP------L
N
RV
L
IKA---
----
Y
HPLLL
R
VL
HWPKTT
L
L
V
A
A
L
SIFTVIW
P
LSQV
G
GE
FLP
KI
N
E
G
DLLYMP
S
T
L
P
G
V
S
PAEAAALLQ
T
TD
K
--
LIKSVPE
V
A
SVF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
ED
QW
R
PG--MTID
K
II
E
EL
DRTVRLPGLAN
L
WVP
P
I
R
NRID
M
LST
G
IK
S
PIGIK
V
SGTVLSDI
D
A
T
AQ---
S
I
EAV
A
KTV
P
-G
V
VS
A
LA
E
R
LE
GGRYID
V
D
IN
RE
KA
S
R
Y
G
MTV
G
D
V
QLF
I
S
S
A
I
G
GAT
V
GETVEGVAR
Y
P
I
N
IR
YPQDY
R
NS
P
QA
L
KQMP
I
L
T
PM
K
QQI
T
L
G
DV
A
DIKVVS
G
P
TM
L
KTE
N
AR
P
ASW
I
YI
D
A
RGRD
M
V
S
V
V
NDIKTAISQK
V
K
L
R
P
G
TSVS
F
S
G
--
-Q
FE
LL
E
HANKKLK
L
M
VP
M
T
V
M
I
I
F
I
L
L
YL
AFRR
VDE
A
LL
I
LM
S
L
P
F
A
L
VG
G
IW
F
LYWQ
G
FH
M
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAI
E
AH
P
E
L
SRKE
TF
TP
EGLD
EA
LYH
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
GAGS
E
VMSR
I
A
A
PM
I
GGM
IT
A
P
LL
S
L
F
II
P
AA
Y
K
L
I
WL
R
RH
K
fig|585055.8.peg.3946
Escherichia coli 55989 (1-1044/1048)
MIEWIIRR
S
VA
NRF
L
V
M
MG
A
L
F
L
S
I
W
G
TWT
I
IN
T
PV
D
AL
P
D
L
SD
V
Q
V
I
I
K
T
S
YPG
Q
A
P
Q
I
V
E
N
Q
VT
Y
PLT
TT
M
LS
V
P
G
AK
T
VRG
F
S
QF-
G
DSY
VYV
I
FE
D
GT
D
LY
W
A
RS
R
V
L
EY
L
N
Q
V
QGK
LP
A-----
GV
SSEIGPDAT
GVG
W
I
FEY
A
LV
D
RSGKHDLS
EL
R
S
L
Q
DWF
L
KFE
L
K
TIP
N
V
A
E
V
ASV
G
GVVKQY
Q
I
Q
V
N
P
VK
L
S
QYG
I
SLPE
V
KQ
A
L
ESS
N
QEAGG
SS
V
--
-
-
--EMAEAEYM
V
R
A
SGY
LQ
S
I
D
D
F
NN
I
V
L
KTGE
N
G
VP
V
Y
L
R
DVA
R
V
Q
T
G
P
E
MRRGI
A
EL
NG
Q
G
E
V
A
G
GV
V
I
L
RS
G
K
N
ARD
V
ITA
V
RDK
L
ET
L
KAS
L
P
E
GV
E
IVTT
YD
RS
QL
I
DR
A
I
D
N
LSSK
L
L
E
EF
I
V
V
A
I
V
C
A
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
I
V
M
H
F
Q
G
L
N
A
N
I
MSL
G
G
I
A
I
A
V
G
A
M
VD
A
AIV
MI
EN
AH
K
R
L
E
E
W
D
HQHP
GEQI
D
NAT
R
WK
V
IT
D
ASV
EVG
P
AL
FISLLI
I
T
LS
FIP
I
F
T
LE
G
QE
G
R
LFG
P
LAF
T
KTY
S
M
AG
AA
A
L
A
I
I
VI
P
I
L
MG
FW
I
RGKIPAETSNP------L
N
RV
L
IKA---
----
Y
HPLLL
R
VL
HWPKTT
L
L
V
A
A
L
SIFTVIW
P
LSQV
G
GE
FLP
KI
N
E
G
DLLYMP
S
T
L
P
G
V
S
PAEAAALLQ
T
TD
K
--
LIKSVPE
V
A
SVF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
ED
QW
R
PG--MTID
K
II
E
EL
DRTVRLPGLAN
L
WVP
P
I
R
NRID
M
LST
G
IK
S
PIGIK
V
SGTVLSDI
D
A
T
AQ---
S
I
EAV
A
KTV
P
-G
V
VS
A
LA
E
R
LE
GGRYID
V
D
IN
RE
KA
S
R
Y
G
MTV
G
D
V
QLF
I
S
S
A
I
G
GAT
V
GETVEGVAR
Y
P
I
N
IR
YPQDY
R
NS
P
QA
L
KQMP
I
L
T
PM
K
QQI
T
L
G
DV
A
DIKVVS
G
P
TM
L
KTE
N
AR
P
ASW
I
YI
D
A
RGRD
M
V
S
V
V
NDIKTAISQK
V
K
L
R
P
G
TSVS
F
S
G
--
-Q
FE
LL
E
HANKKLK
L
M
VP
M
T
V
M
I
I
F
I
L
L
YL
AFRR
VDE
A
LL
I
LM
S
L
P
F
A
L
VG
G
IW
F
LYWQ
G
FH
M
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAI
E
AH
P
E
L
SRKE
TF
TP
EGLD
EA
LYH
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
GAGS
E
VMSR
I
A
A
PM
I
GGM
IT
A
P
LL
S
L
F
II
P
AA
Y
K
L
I
WL
R
RH
K
fig|405955.13.peg.5316
Escherichia coli APEC O1 (1-1044/1048)
MIEWIIRR
S
VA
NRF
L
V
M
MG
A
L
F
L
S
I
W
G
TWT
I
IN
T
PV
D
AL
P
D
L
SD
V
Q
V
I
I
K
T
S
YPG
Q
A
P
Q
I
V
E
N
Q
VT
Y
PLT
TT
M
LS
V
P
G
AK
T
VRG
F
S
QF-
G
DSY
VYV
I
FE
D
GT
D
LY
W
A
RS
R
V
L
EY
L
N
Q
V
QGK
LP
A-----
GV
SSEIGPDAT
GVG
W
I
FEY
A
LV
D
RSGKHDLS
EL
R
S
L
Q
DWF
L
KFE
L
K
TIP
N
V
A
E
V
ASV
G
GVVKQY
Q
I
Q
V
N
P
VK
L
S
QYG
I
SLPE
V
KQ
A
L
ESS
N
QEAGG
SS
V
--
-
-
--EMAEAEYM
V
R
A
SGY
LQ
S
I
D
D
F
NN
I
V
L
KTGE
N
G
VP
V
Y
L
R
DVA
R
V
Q
T
G
P
E
MRRGI
A
EL
NG
Q
G
E
V
A
G
GV
V
I
L
RS
G
K
N
ARD
V
ITA
V
RDK
L
ET
L
KAS
L
P
E
GV
E
IVTT
YD
RS
QL
I
DR
A
I
D
N
LSSK
L
L
E
EF
I
V
V
A
I
V
C
A
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
I
V
M
H
F
Q
G
L
N
A
N
I
MSL
G
G
I
A
I
A
V
G
A
M
VD
A
AIV
MI
EN
AH
K
R
L
E
E
W
D
HQHP
GEQI
D
NAT
R
WK
V
IT
D
ASV
EVG
P
AL
FISLLI
I
T
LS
FIP
I
F
T
LE
G
QE
G
R
LFG
P
LAF
T
KTY
S
M
AG
AA
A
L
A
I
I
VI
P
I
L
MG
FW
I
RGKIPAETSNP------L
N
RV
L
IKA---
----
Y
HPLLL
R
VL
HWPKTT
L
L
V
A
A
L
SIFTVIW
P
LSQV
G
GE
FLP
KI
N
E
G
DLLYMP
S
T
L
P
G
V
S
PAEAAALLQ
T
TD
K
--
LIKSVPE
V
A
SVF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
ED
QW
R
PG--MTID
K
II
E
EL
DRTVRLPGLAN
L
WVP
P
I
R
NRID
M
LST
G
IK
S
PIGIK
V
SGTVLSDI
D
A
T
AQ---
S
I
EAV
A
KTV
P
-G
V
VS
A
LA
E
R
LE
GGRYID
V
D
IN
RE
KA
S
R
Y
G
MTV
G
D
V
QLF
I
S
S
A
I
G
GAT
V
GETVEGVAR
Y
P
I
N
IR
YPQDY
R
NS
P
QA
L
KQMP
I
L
T
PM
K
QQI
T
L
G
DV
A
DIKVVS
G
P
TM
L
KTE
N
AR
P
ASW
I
YI
D
A
RGRD
M
V
S
V
V
NDIKTAISQK
V
K
L
R
P
G
TSVS
F
S
G
--
-Q
FE
LL
E
HANKKLK
L
M
VP
M
T
V
M
I
I
F
I
L
L
YL
AFRR
VDE
A
LL
I
LM
S
L
P
F
A
L
VG
G
IW
F
LYWQ
G
FH
M
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAI
E
AH
P
E
L
SRKE
TF
TP
EGLD
EA
LYH
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
GAGS
E
VMSR
I
A
A
PM
I
GGM
IT
A
P
LL
S
L
F
II
P
AA
Y
K
L
I
WL
R
RH
K
fig|405955.9.peg.4433
Escherichia coli APEC O1 (1-1044/1048)
MIEWIIRR
S
VA
NRF
L
V
M
MG
A
L
F
L
S
I
W
G
TWT
I
IN
T
PV
D
AL
P
D
L
SD
V
Q
V
I
I
K
T
S
YPG
Q
A
P
Q
I
V
E
N
Q
VT
Y
PLT
TT
M
LS
V
P
G
AK
T
VRG
F
S
QF-
G
DSY
VYV
I
FE
D
GT
D
LY
W
A
RS
R
V
L
EY
L
N
Q
V
QGK
LP
A-----
GV
SSEIGPDAT
GVG
W
I
FEY
A
LV
D
RSGKHDLS
EL
R
S
L
Q
DWF
L
KFE
L
K
TIP
N
V
A
E
V
ASV
G
GVVKQY
Q
I
Q
V
N
P
VK
L
S
QYG
I
SLPE
V
KQ
A
L
ESS
N
QEAGG
SS
V
--
-
-
--EMAEAEYM
V
R
A
SGY
LQ
S
I
D
D
F
NN
I
V
L
KTGE
N
G
VP
V
Y
L
R
DVA
R
V
Q
T
G
P
E
MRRGI
A
EL
NG
Q
G
E
V
A
G
GV
V
I
L
RS
G
K
N
ARD
V
ITA
V
RDK
L
ET
L
KAS
L
P
E
GV
E
IVTT
YD
RS
QL
I
DR
A
I
D
N
LSSK
L
L
E
EF
I
V
V
A
I
V
C
A
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
I
V
M
H
F
Q
G
L
N
A
N
I
MSL
G
G
I
A
I
A
V
G
A
M
VD
A
AIV
MI
EN
AH
K
R
L
E
E
W
D
HQHP
GEQI
D
NAT
R
WK
V
IT
D
ASV
EVG
P
AL
FISLLI
I
T
LS
FIP
I
F
T
LE
G
QE
G
R
LFG
P
LAF
T
KTY
S
M
AG
AA
A
L
A
I
I
VI
P
I
L
MG
FW
I
RGKIPAETSNP------L
N
RV
L
IKA---
----
Y
HPLLL
R
VL
HWPKTT
L
L
V
A
A
L
SIFTVIW
P
LSQV
G
GE
FLP
KI
N
E
G
DLLYMP
S
T
L
P
G
V
S
PAEAAALLQ
T
TD
K
--
LIKSVPE
V
A
SVF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
ED
QW
R
PG--MTID
K
II
E
EL
DRTVRLPGLAN
L
WVP
P
I
R
NRID
M
LST
G
IK
S
PIGIK
V
SGTVLSDI
D
A
T
AQ---
S
I
EAV
A
KTV
P
-G
V
VS
A
LA
E
R
LE
GGRYID
V
D
IN
RE
KA
S
R
Y
G
MTV
G
D
V
QLF
I
S
S
A
I
G
GAT
V
GETVEGVAR
Y
P
I
N
IR
YPQDY
R
NS
P
QA
L
KQMP
I
L
T
PM
K
QQI
T
L
G
DV
A
DIKVVS
G
P
TM
L
KTE
N
AR
P
ASW
I
YI
D
A
RGRD
M
V
S
V
V
NDIKTAISQK
V
K
L
R
P
G
TSVS
F
S
G
--
-Q
FE
LL
E
HANKKLK
L
M
VP
M
T
V
M
I
I
F
I
L
L
YL
AFRR
VDE
A
LL
I
LM
S
L
P
F
A
L
VG
G
IW
F
LYWQ
G
FH
M
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAI
E
AH
P
E
L
SRKE
TF
TP
EGLD
EA
LYH
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
GAGS
E
VMSR
I
A
A
PM
I
GGM
IT
A
P
LL
S
L
F
II
P
AA
Y
K
L
I
WL
R
RH
K
fig|481805.3.peg.3679
Escherichia coli ATCC 8739 (1-1044/1048)
MIEWIIRR
S
VA
NRF
L
V
M
MG
A
L
F
L
S
I
W
G
TWT
I
IN
T
PV
D
AL
P
D
L
SD
V
Q
V
I
I
K
T
S
YPG
Q
A
P
Q
I
V
E
N
Q
VT
Y
PLT
TT
M
LS
V
P
G
AK
T
VRG
F
S
QF-
G
DSY
VYV
I
FE
D
GT
D
LY
W
A
RS
R
V
L
EY
L
N
Q
V
QGK
LP
A-----
GV
SSEIGPDAT
GVG
W
I
FEY
A
LV
D
RSGKHDLS
EL
R
S
L
Q
DWF
L
KFE
L
K
TIP
N
V
A
E
V
ASV
G
GVVKQY
Q
I
Q
V
N
P
VK
L
S
QYG
I
SLPE
V
KQ
A
L
ESS
N
QEAGG
SS
V
--
-
-
--EIAEAEYM
V
R
A
SGY
LQ
S
I
D
D
F
NN
I
V
L
KTGE
N
G
VP
V
Y
L
R
DVA
R
V
Q
T
G
P
E
MRRGI
A
EL
NG
Q
G
E
V
A
G
GV
V
I
L
RS
G
K
N
ARD
V
ITA
V
KDK
L
DT
L
KAS
L
P
E
GV
E
IVTT
YD
RS
QL
I
DR
A
I
D
N
LSSK
L
L
E
EF
F
V
V
A
I
V
C
A
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
I
V
M
H
F
Q
G
L
N
A
N
I
MSL
G
G
I
A
I
A
V
G
A
M
VD
A
AIV
MI
EN
AH
K
R
L
E
E
W
D
HQHP
GEQI
D
NAT
R
WK
V
IT
D
ASV
EVG
P
AL
FISLLI
I
T
LS
FIP
I
F
T
LE
G
QE
G
R
LFG
P
LAF
T
KTY
S
M
AG
AA
A
L
A
I
I
VI
P
I
L
MG
FW
I
RGKIPAETSNP------L
N
RV
L
IKA---
----
Y
HPLLL
R
VL
HWPKTT
L
L
V
A
A
L
SIFTVIW
P
LSQV
G
GE
FLP
KI
N
E
G
DLLYMP
S
T
L
P
G
V
S
PAEAAALLQ
T
TD
K
--
LIKSVPE
V
A
SVF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
ED
QW
R
PG--MTID
K
II
E
EL
DRTVRLPGLAN
L
WVP
P
I
R
NRID
M
LST
G
IK
S
PIGIK
V
SGTVLSDI
D
V
T
AQ---
S
I
EAV
A
KTV
P
-G
V
VS
A
LA
E
R
LE
GGRYID
V
D
IN
RE
KA
S
R
Y
G
MTV
G
D
V
QLF
V
S
S
A
I
G
GAM
V
GETVEGVAR
Y
P
I
N
IR
YPQDY
R
NS
P
QA
L
REMP
I
L
T
PM
K
QQI
T
L
G
DV
A
DIKVVS
G
P
TM
L
KTE
N
AR
P
ASW
I
YV
D
A
RGRD
M
V
S
V
V
NDIKTAISEK
V
K
L
R
P
G
TSVA
F
S
G
--
-Q
FE
LL
E
HANKKLK
L
M
VP
M
T
V
M
I
I
F
I
L
L
YL
AFRR
VDE
A
LL
I
LM
S
L
P
F
A
L
VG
G
IW
F
LYWQ
G
FH
M
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAI
E
AH
P
E
L
SRKE
TF
TP
EGLD
EA
LYH
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
GAGS
E
VMSR
I
A
A
PM
I
GGM
IT
A
P
LL
S
L
F
II
P
AA
Y
K
L
I
WL
R
K
H
K
fig|481805.6.peg.3657
Escherichia coli ATCC 8739 (1-1044/1048)
MIEWIIRR
S
VA
NRF
L
V
M
MG
A
L
F
L
S
I
W
G
TWT
I
IN
T
PV
D
AL
P
D
L
SD
V
Q
V
I
I
K
T
S
YPG
Q
A
P
Q
I
V
E
N
Q
VT
Y
PLT
TT
M
LS
V
P
G
AK
T
VRG
F
S
QF-
G
DSY
VYV
I
FE
D
GT
D
LY
W
A
RS
R
V
L
EY
L
N
Q
V
QGK
LP
A-----
GV
SSEIGPDAT
GVG
W
I
FEY
A
LV
D
RSGKHDLS
EL
R
S
L
Q
DWF
L
KFE
L
K
TIP
N
V
A
E
V
ASV
G
GVVKQY
Q
I
Q
V
N
P
VK
L
S
QYG
I
SLPE
V
KQ
A
L
ESS
N
QEAGG
SS
V
--
-
-
--EIAEAEYM
V
R
A
SGY
LQ
S
I
D
D
F
NN
I
V
L
KTGE
N
G
VP
V
Y
L
R
DVA
R
V
Q
T
G
P
E
MRRGI
A
EL
NG
Q
G
E
V
A
G
GV
V
I
L
RS
G
K
N
ARD
V
ITA
V
KDK
L
DT
L
KAS
L
P
E
GV
E
IVTT
YD
RS
QL
I
DR
A
I
D
N
LSSK
L
L
E
EF
F
V
V
A
I
V
C
A
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
I
V
M
H
F
Q
G
L
N
A
N
I
MSL
G
G
I
A
I
A
V
G
A
M
VD
A
AIV
MI
EN
AH
K
R
L
E
E
W
D
HQHP
GEQI
D
NAT
R
WK
V
IT
D
ASV
EVG
P
AL
FISLLI
I
T
LS
FIP
I
F
T
LE
G
QE
G
R
LFG
P
LAF
T
KTY
S
M
AG
AA
A
L
A
I
I
VI
P
I
L
MG
FW
I
RGKIPAETSNP------L
N
RV
L
IKA---
----
Y
HPLLL
R
VL
HWPKTT
L
L
V
A
A
L
SIFTVIW
P
LSQV
G
GE
FLP
KI
N
E
G
DLLYMP
S
T
L
P
G
V
S
PAEAAALLQ
T
TD
K
--
LIKSVPE
V
A
SVF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
ED
QW
R
PG--MTID
K
II
E
EL
DRTVRLPGLAN
L
WVP
P
I
R
NRID
M
LST
G
IK
S
PIGIK
V
SGTVLSDI
D
V
T
AQ---
S
I
EAV
A
KTV
P
-G
V
VS
A
LA
E
R
LE
GGRYID
V
D
IN
RE
KA
S
R
Y
G
MTV
G
D
V
QLF
V
S
S
A
I
G
GAM
V
GETVEGVAR
Y
P
I
N
IR
YPQDY
R
NS
P
QA
L
REMP
I
L
T
PM
K
QQI
T
L
G
DV
A
DIKVVS
G
P
TM
L
KTE
N
AR
P
ASW
I
YV
D
A
RGRD
M
V
S
V
V
NDIKTAISEK
V
K
L
R
P
G
TSVA
F
S
G
--
-Q
FE
LL
E
HANKKLK
L
M
VP
M
T
V
M
I
I
F
I
L
L
YL
AFRR
VDE
A
LL
I
LM
S
L
P
F
A
L
VG
G
IW
F
LYWQ
G
FH
M
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAI
E
AH
P
E
L
SRKE
TF
TP
EGLD
EA
LYH
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
GAGS
E
VMSR
I
A
A
PM
I
GGM
IT
A
P
LL
S
L
F
II
P
AA
Y
K
L
I
WL
R
K
H
K
fig|316401.4.peg.250
Escherichia coli ETEC H10407 (1-1044/1048)
MIEWIIRR
S
VA
NRF
L
V
M
MG
A
L
F
L
S
I
W
G
TWT
I
IN
T
PV
D
AL
P
D
L
SE
V
Q
V
I
I
K
T
S
YPG
Q
A
P
Q
I
V
E
N
Q
VT
Y
PLT
TT
M
LS
V
P
G
AK
T
VRG
F
S
QF-
G
DSY
VYV
I
FE
D
GT
D
LY
W
A
RS
R
V
L
EY
L
N
Q
V
QGK
LP
A-----
GV
SSEIGPDAT
GVG
W
I
FEY
A
LV
D
RSGKHDLS
EL
R
S
L
Q
DWF
L
KFE
L
K
TIP
N
V
A
E
V
ASV
G
GVVKQY
Q
I
Q
V
N
P
VK
L
S
QYG
I
SLPE
V
KQ
A
L
ESS
N
QEAGG
SS
V
--
-
-
--EIAEAEYM
V
R
A
SGY
LQ
S
I
D
D
F
NN
I
V
L
KTGE
N
G
VP
V
Y
L
R
DVA
R
V
Q
T
G
P
E
MRRGI
A
EL
NG
Q
G
E
V
A
G
GV
V
I
L
RS
G
K
N
ARD
V
ITA
V
KDK
L
DT
L
KAS
L
P
E
GV
E
IVTT
YD
RS
QL
I
DR
A
I
D
N
LSSK
L
L
E
EF
F
V
V
A
I
V
C
A
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
I
V
M
H
F
Q
G
L
N
A
N
I
MSL
G
G
I
A
I
A
V
G
A
M
VD
A
AIV
MI
EN
AH
K
R
L
E
E
W
D
HQHP
GEQI
D
NAT
R
WK
V
IT
D
ASV
EVG
P
AL
FISLLI
I
T
LS
FIP
I
F
T
LE
G
QE
G
R
LFG
P
LAF
T
KTY
S
M
AG
AA
A
L
A
I
I
VI
P
I
L
MG
FW
I
RGKIPAETSNP------L
N
RV
L
IKA---
----
Y
HPLLL
R
VL
HWPKTT
L
L
V
A
A
L
SIFTVIW
P
LSQV
G
GE
FLP
KI
N
E
G
DLLYMP
S
T
L
P
G
V
S
PAEAAALLQ
T
TD
K
--
LIKSVPE
V
A
SVF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
ED
QW
R
PG--MTID
K
II
E
EL
DRTVRLPGLAN
L
WVP
P
I
R
NRID
M
LST
G
IK
S
PIGIK
V
SGTVLSDI
D
V
T
AQ---
S
I
EAV
A
KTV
P
-G
V
VS
A
LA
E
R
LE
GGRYID
V
D
IN
RE
KA
S
R
Y
G
MTV
G
D
V
QLF
V
S
S
A
I
G
GAM
V
GETVEGVAR
Y
P
I
N
IR
YPQDY
R
NS
P
QA
L
REMP
I
L
T
PM
K
QQI
T
L
G
DV
A
DIKVVS
G
P
TM
L
KTE
N
AR
P
ASW
I
YV
D
A
RGRD
M
V
S
V
V
NDIKTAISEK
V
K
L
R
P
G
TSVA
F
S
G
--
-Q
FE
LL
E
HANKKLK
L
M
VP
M
T
V
M
I
I
F
I
L
L
YL
AFRR
VDE
A
LL
I
LM
S
L
P
F
A
L
VG
G
IW
F
LYWQ
G
FH
M
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAI
E
AH
P
E
L
SRKE
TF
TP
EGLD
EA
LYH
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
GAGS
E
VMSR
I
A
A
PM
I
GGM
IT
A
P
LL
S
L
F
II
P
AA
Y
K
L
I
WL
R
K
H
K
fig|216593.1.peg.1927
Escherichia coli E2348/69 (5-1023/1035)
FF
V
RRPV
F
ARV
I
----
AI
L
I
M
L
A
G
ILA
I
RT
LPV
A
QYP
D
V
AP
P
T
I
K
I
S
A
T
Y
T
GA
S
A
E
T
L
E
N
S
VT
Q
VIE
QQ
L
TG
L
D
N
L
L
Y
F
SS
T
S
SSD
G
SVS
I
N
V
T
FE
Q
GT
D
PD
T
A
QV
QVQ
NK
I
Q
Q
A
ESR
LP
SEVQQT
GV
TVE-KSQSN
---
F
L
LIA
A
VY
D
TTDKASSS
DI
A
D
W
L
VSN
V
QDP
L
A
RVE
GVG
S
L
QVF
G
AEY-AM
RI
W
LDP
AK
L
A
SYS
L
MPSD
V
QS
AI
EAQ
N
VQVTA
G
K
I
G
A
L
P
SPDTQQLTAT
V
R
A
QSR
LQT
V
D
Q
F
KN
I
I
V
KSQS
DG
AV
V
R
I
K
DVA
R
VE
M
G
S
E
DYTAI
G
KL
NG
H
-
P
S
A
G
VA
V
M
L
SP
GAN
ALN
T
ATL
V
KDK
I
AE
F
QRN
M
P
Q
G
YD
IAYP
K
D
S
T
EF
I
KI
S
V
E
D
VIQT
L
F
EAI
V
LV
V
C
V
M
YLFL
Q
N
L
RATLIP
A
L
AVPV
V
L
L
GTF
G
VL
A
L
F
G
Y
S
I
N
T
LT
L
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
R
D
----------
E
GLP
A
RE
A
TE
K
SMG
E
I
S
G
AL
VAIALV
L
S
AVF
L
PM
A
F
FG
G
ST
G
V
IYR
Q
FSIT
IIS
AM
LL
SV
V
VAL
T
LTP
A
LC
G
SV
L
QHVPPH----KKGFFGAF
N
RF
Y
RRTEDK
----
Y
QRGVI
Y
VL
RRAART
M
G
L
Y
V
V
LGGGMAL
M
MWKL
P
GS
FLP
TE
D
Q
G
EIMVQY
T
L
P
A
G
A
T
AARTAEVNR
Q
IV
D
WF
LINEKAN
T
D
V
I
F
TVD
G
FSFSGSGQ
N
TGMAF
---
V
S
LK
N
WS
Q
-
R
KGAENTAQ
AI
A
L
RA
TKELGTIRDAT
V
F--
A
M
-
TPPA
V
DGL
G
QS
N
GFTFE
L
LANGGTDR
E
T
L
LQMRN
QL
IEK
A
NQS
P
-E
L
HS
V
RA
N
D
L
P
QMPQLQ
V
D
I
D
SN
KA
V
S
L
G
L
SL
N
D
V
TDT
L
S
S
A
W
G
GTY
V
NDFIDRGRV
K
K
V
Y
I
Q
GDSEF
R
SA
P
SD
L
GKWF
V
R
G
SD
N
AMT
P
F
S
AF
A
TTRWLY
G
P
ER
L
VRY
N
GS
A
AYE
I
QG
E
N
ATGF
S
S
G
D
A
MTKMEELANS
L
-
-
P
A
G
TTWA
W
S
G
--
LS
L
Q
EK
L
ASGQALS
L
Y
A
-
V
S
I
L
V
VFL
C
L
AA
LYES
WSV
P
FS
V
I
L
V
I
P
L
G
L
L
G
A
A
LA
AWMR
D
LN
NDV
YFQV
A
L
L
TT
IGL
S
S
KNAILIV
E
FA
-EAA
V
AE
----------
G
YSLS
R
A
ALR
A
AQT
R
L
RPI
I
MT
S
LA
F
I
A
G
V
M
PL
AI
A
T
GAG
A
N
SRIA
I
G
T
G
II
GG
T
LT
A
T
LLAIF
FV
P
LF
F
V
LV
fig|574521.7.peg.1509
Escherichia coli O127:H6 str. E2348/69 (5-1023/1035)
FF
V
RRPV
F
ARV
I
----
AI
L
I
M
L
A
G
ILA
I
RT
LPV
A
QYP
D
V
AP
P
T
I
K
I
S
A
T
Y
T
GA
S
A
E
T
L
E
N
S
VT
Q
VIE
QQ
L
TG
L
D
N
L
L
Y
F
SS
T
S
SSD
G
SVS
I
N
V
T
FE
Q
GT
D
PD
T
A
QV
QVQ
NK
I
Q
Q
A
ESR
LP
SEVQQT
GV
TVE-KSQSN
---
F
L
LIA
A
VY
D
TTDKASSS
DI
A
D
W
L
VSN
V
QDP
L
A
RVE
GVG
S
L
QVF
G
AEY-AM
RI
W
LDP
AK
L
A
SYS
L
MPSD
V
QS
AI
EAQ
N
VQVTA
G
K
I
G
A
L
P
SPDTQQLTAT
V
R
A
QSR
LQT
V
D
Q
F
KN
I
I
V
KSQS
DG
AV
V
R
I
K
DVA
R
VE
M
G
S
E
DYTAI
G
KL
NG
H
-
P
S
A
G
VA
V
M
L
SP
GAN
ALN
T
ATL
V
KDK
I
AE
F
QRN
M
P
Q
G
YD
IAYP
K
D
S
T
EF
I
KI
S
V
E
D
VIQT
L
F
EAI
V
LV
V
C
V
M
YLFL
Q
N
L
RATLIP
A
L
AVPV
V
L
L
GTF
G
VL
A
L
F
G
Y
S
I
N
T
LT
L
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
R
D
----------
E
GLP
A
RE
A
TE
K
SMG
E
I
S
G
AL
VAIALV
L
S
AVF
L
PM
A
F
FG
G
ST
G
V
IYR
Q
FSIT
IIS
AM
LL
SV
V
VAL
T
LTP
A
LC
G
SV
L
QHVPPH----KKGFFGAF
N
RF
Y
RRTEDK
----
Y
QRGVI
Y
VL
RRAART
M
G
L
Y
V
V
LGGGMAL
M
MWKL
P
GS
FLP
TE
D
Q
G
EIMVQY
T
L
P
A
G
A
T
AARTAEVNR
Q
IV
D
WF
LINEKAN
T
D
V
I
F
TVD
G
FSFSGSGQ
N
TGMAF
---
V
S
LK
N
WS
Q
-
R
KGAENTAQ
AI
A
L
RA
TKELGTIRDAT
V
F--
A
M
-
TPPA
V
DGL
G
QS
N
GFTFE
L
LANGGTDR
E
T
L
LQMRN
QL
IEK
A
NQS
P
-E
L
HS
V
RA
N
D
L
P
QMPQLQ
V
D
I
D
SN
KA
V
S
L
G
L
SL
N
D
V
TDT
L
S
S
A
W
G
GTY
V
NDFIDRGRV
K
K
V
Y
I
Q
GDSEF
R
SA
P
SD
L
GKWF
V
R
G
SD
N
AMT
P
F
S
AF
A
TTRWLY
G
P
ER
L
VRY
N
GS
A
AYE
I
QG
E
N
ATGF
S
S
G
D
A
MTKMEELANS
L
-
-
P
A
G
TTWA
W
S
G
--
LS
L
Q
EK
L
ASGQALS
L
Y
A
-
V
S
I
L
V
VFL
C
L
AA
LYES
WSV
P
FS
V
I
L
V
I
P
L
G
L
L
G
A
A
LA
AWMR
D
LN
NDV
YFQV
A
L
L
TT
IGL
S
S
KNAILIV
E
FA
-EAA
V
AE
----------
G
YSLS
R
A
ALR
A
AQT
R
L
RPI
I
MT
S
LA
F
I
A
G
V
M
PL
AI
A
T
GAG
A
N
SRIA
I
G
T
G
II
GG
T
LT
A
T
LLAIF
FV
P
LF
F
V
LV
fig|585397.7.peg.1507
Escherichia coli ED1a (17-1023/1035)
AI
L
I
M
L
A
G
ILA
I
RT
LPV
A
QYP
D
V
AP
P
T
I
K
I
S
A
T
Y
T
GA
S
A
E
T
L
E
N
S
VT
Q
VIE
QQ
L
TG
L
D
N
L
L
Y
F
SS
T
S
SSD
G
SVS
I
N
V
T
FE
Q
GT
D
PD
T
A
QV
QVQ
NK
I
Q
Q
A
ESR
LP
SEVQQT
GV
TVE-KSQSN
---
F
L
LIA
A
VY
D
TTDKASSS
DI
A
D
W
L
VSN
V
QDP
L
A
RVE
GVG
S
L
QVF
G
AEY-AM
RI
W
LDP
AK
L
A
SYS
L
MPSD
V
QS
AI
EAQ
N
VQVTA
G
K
I
G
A
L
P
SPDTQQLTAT
V
R
A
QSR
LQT
V
D
Q
F
KN
I
I
V
KSQS
DG
AV
V
R
I
K
DVA
R
VE
M
G
S
E
DYTAI
G
KL
NG
H
-
P
S
A
G
VA
V
M
L
SP
GAN
ALN
T
ATL
V
KDK
I
AE
F
QRN
M
P
Q
G
YD
IAYP
K
D
S
T
EF
I
KI
S
V
E
D
VIQT
L
F
EAI
V
LV
V
C
V
M
YLFL
Q
N
L
RATLIP
A
L
AVPV
V
L
L
GTF
G
VL
A
L
F
G
Y
S
I
N
T
LT
L
F
A
M
V
Q
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
R
D
----------
E
GLP
A
PE
A
TE
K
SMG
E
I
S
G
AL
VAIALV
L
S
AVF
L
PM
A
F
FG
G
ST
G
V
IYR
Q
FSIT
IIS
AM
LL
SV
V
VAL
T
LTP
A
LC
G
SV
L
QHVPPH----KKGFFGAF
N
RF
Y
RRTEDK
----
Y
QRGVI
Y
VL
RRTART
M
G
L
Y
V
V
LGGGMAL
M
MWKL
P
GS
FLP
TE
D
Q
G
EIMVQY
T
L
P
A
G
A
T
AARTAEVNR
Q
IV
D
WF
LINEKAN
T
D
V
I
F
TVD
G
FSFSGSGQ
N
TGMAF
---
V
S
LK
N
WS
Q
-
R
KGAENTAQ
AI
A
L
RA
TKELGTIRDAT
V
F--
A
M
-
TPPA
V
DGL
G
QS
N
GFTFE
L
LANGGTDR
E
T
L
LQMRN
QL
IEK
A
NQS
P
-E
L
HS
V
RA
N
D
L
P
QMPQLQ
V
D
I
D
SN
KA
V
S
L
G
L
SL
N
D
V
TDT
L
S
S
A
W
G
GTY
V
NDFIDRGRV
K
K
V
Y
I
Q
GDSEF
R
SA
P
SD
L
GKWF
V
R
G
SD
N
AMT
P
F
S
AF
A
TTRWLY
G
P
ER
L
VRY
N
GS
A
AYE
I
QG
E
N
ATGF
S
S
G
D
A
MTKMEELANS
L
-
-
P
A
G
TTWA
W
S
G
--
LS
L
Q
EK
L
ASGQALS
L
Y
A
-
V
S
I
L
V
VFL
C
L
AA
LYES
WSV
P
FS
V
I
L
V
I
P
L
G
L
L
G
A
A
LA
AWMR
D
LN
NDV
YFQV
A
L
L
TT
IGL
S
S
KNAILIV
E
FA
-EAA
V
AE
----------
G
YSLS
R
A
ALR
A
AQT
R
L
RPI
I
MT
S
LA
F
I
A
G
V
M
PL
AI
A
T
GAG
A
N
SRIA
I
G
T
G
II
GG
T
LT
A
T
LLAIF
FV
P
LF
F
V
LV
fig|585397.9.peg.1501
Escherichia coli ED1a (17-1023/1035)
AI
L
I
M
L
A
G
ILA
I
RT
LPV
A
QYP
D
V
AP
P
T
I
K
I
S
A
T
Y
T
GA
S
A
E
T
L
E
N
S
VT
Q
VIE
QQ
L
TG
L
D
N
L
L
Y
F
SS
T
S
SSD
G
SVS
I
N
V
T
FE
Q
GT
D
PD
T
A
QV
QVQ
NK
I
Q
Q
A
ESR
LP
SEVQQT
GV
TVE-KSQSN
---
F
L
LIA
A
VY
D
TTDKASSS
DI
A
D
W
L
VSN
V
QDP
L
A
RVE
GVG
S
L
QVF
G
AEY-AM
RI
W
LDP
AK
L
A
SYS
L
MPSD
V
QS
AI
EAQ
N
VQVTA
G
K
I
G
A
L
P
SPDTQQLTAT
V
R
A
QSR
LQT
V
D
Q
F
KN
I
I
V
KSQS
DG
AV
V
R
I
K
DVA
R
VE
M
G
S
E
DYTAI
G
KL
NG
H
-
P
S
A
G
VA
V
M
L
SP
GAN
ALN
T
ATL
V
KDK
I
AE
F
QRN
M
P
Q
G
YD
IAYP
K
D
S
T
EF
I
KI
S
V
E
D
VIQT
L
F
EAI
V
LV
V
C
V
M
YLFL
Q
N
L
RATLIP
A
L
AVPV
V
L
L
GTF
G
VL
A
L
F
G
Y
S
I
N
T
LT
L
F
A
M
V
Q
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
R
D
----------
E
GLP
A
PE
A
TE
K
SMG
E
I
S
G
AL
VAIALV
L
S
AVF
L
PM
A
F
FG
G
ST
G
V
IYR
Q
FSIT
IIS
AM
LL
SV
V
VAL
T
LTP
A
LC
G
SV
L
QHVPPH----KKGFFGAF
N
RF
Y
RRTEDK
----
Y
QRGVI
Y
VL
RRTART
M
G
L
Y
V
V
LGGGMAL
M
MWKL
P
GS
FLP
TE
D
Q
G
EIMVQY
T
L
P
A
G
A
T
AARTAEVNR
Q
IV
D
WF
LINEKAN
T
D
V
I
F
TVD
G
FSFSGSGQ
N
TGMAF
---
V
S
LK
N
WS
Q
-
R
KGAENTAQ
AI
A
L
RA
TKELGTIRDAT
V
F--
A
M
-
TPPA
V
DGL
G
QS
N
GFTFE
L
LANGGTDR
E
T
L
LQMRN
QL
IEK
A
NQS
P
-E
L
HS
V
RA
N
D
L
P
QMPQLQ
V
D
I
D
SN
KA
V
S
L
G
L
SL
N
D
V
TDT
L
S
S
A
W
G
GTY
V
NDFIDRGRV
K
K
V
Y
I
Q
GDSEF
R
SA
P
SD
L
GKWF
V
R
G
SD
N
AMT
P
F
S
AF
A
TTRWLY
G
P
ER
L
VRY
N
GS
A
AYE
I
QG
E
N
ATGF
S
S
G
D
A
MTKMEELANS
L
-
-
P
A
G
TTWA
W
S
G
--
LS
L
Q
EK
L
ASGQALS
L
Y
A
-
V
S
I
L
V
VFL
C
L
AA
LYES
WSV
P
FS
V
I
L
V
I
P
L
G
L
L
G
A
A
LA
AWMR
D
LN
NDV
YFQV
A
L
L
TT
IGL
S
S
KNAILIV
E
FA
-EAA
V
AE
----------
G
YSLS
R
A
ALR
A
AQT
R
L
RPI
I
MT
S
LA
F
I
A
G
V
M
PL
AI
A
T
GAG
A
N
SRIA
I
G
T
G
II
GG
T
LT
A
T
LLAIF
FV
P
LF
F
V
LV
fig|550676.3.peg.848
Escherichia coli B185 (17-1023/1035)
AI
L
I
M
L
A
G
ILA
I
RT
LPV
A
QYP
D
V
AP
P
T
I
K
I
S
A
T
Y
T
GA
S
A
E
T
L
E
N
S
VT
Q
VIE
QQ
L
TG
L
D
N
L
L
Y
F
SS
T
S
SSD
G
SVS
I
N
V
T
FE
Q
GT
D
PD
T
A
QV
QVQ
NK
I
Q
Q
A
ESR
LP
SEVQQT
GV
TVE-KSQSN
---
F
L
LIA
A
VY
D
TTDKASSS
DI
A
D
W
L
VSN
V
QDP
L
A
RVE
GVG
S
L
QVF
G
AEY-AM
RI
W
LDP
AK
L
A
SYS
L
MPSD
V
QS
AI
EAQ
N
VQVTA
G
K
I
G
A
L
P
SPNTQQLTAT
V
R
A
QSR
LQT
V
D
Q
F
KN
I
I
V
KSQS
DG
AV
V
R
I
K
DVA
R
VE
M
G
S
E
DYTAI
G
KL
NG
H
-
P
S
A
G
VA
V
M
L
SP
GAN
ALN
T
ATL
V
KDK
I
AE
F
QRN
M
P
Q
G
YD
IAYP
K
D
S
T
EF
I
KI
S
V
E
D
VIQT
L
F
EAI
V
LV
V
C
V
M
YLFL
Q
N
L
RATLIP
A
L
AVPV
V
L
L
GTF
G
VL
A
L
F
G
Y
S
I
N
T
LT
L
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
R
D
----------
E
GLP
A
RE
A
TE
K
SMG
E
I
S
G
AL
VAIALV
L
S
AVF
L
PM
A
F
FG
G
ST
G
V
IYR
Q
FSIT
IIS
AM
LL
SV
V
VAL
T
LTP
A
LC
G
SV
L
QHVPPH----KKGFFGAF
N
RF
Y
RRTEDK
----
Y
QRGVI
Y
VL
RRAART
M
G
L
Y
L
V
LGGGMAL
M
MWKL
P
GS
FLP
TE
D
Q
G
EIMVQY
T
L
P
A
G
A
T
AARTAEVNR
Q
IV
D
WF
LINEKAN
T
D
V
I
F
TVD
G
FSFSGSGQ
N
TGMAF
---
V
S
LK
N
WS
Q
-
R
KGAENTAQ
AI
A
L
RA
TKELGTIRDAT
V
F--
A
M
-
TPPA
V
DGL
G
QS
N
GFTFE
L
LANGGTDR
E
T
L
LQMRN
QL
IEK
A
NQS
P
-E
L
HS
V
RA
N
D
L
P
QMPQLQ
V
D
I
D
SN
KA
V
S
L
G
L
SL
N
D
V
TDT
L
S
S
A
W
G
GTY
V
NDFIDRGRV
K
K
V
Y
I
Q
GDSEF
R
SA
P
SD
L
GKWF
V
R
G
SD
N
AMT
P
F
S
AF
A
TTRWLY
G
P
ER
L
VRY
N
GS
A
AYE
I
QG
E
N
ATGF
S
S
G
D
A
MTKMEELANS
L
-
-
P
A
G
TTWA
W
S
G
--
LS
L
Q
EK
L
ASGQALS
L
Y
A
-
V
S
I
L
V
VFL
C
L
AA
LYES
WSV
P
FS
V
I
L
V
I
P
L
G
L
L
G
A
A
LA
AWMR
D
LN
NDV
YFQV
A
L
L
TT
IGL
S
S
KNAILIV
E
FA
-EAA
V
AE
----------
G
YSLS
R
A
ALR
A
AQT
R
L
RPI
I
MT
S
LA
F
I
A
G
V
M
PL
AI
A
T
GAG
A
N
SRIA
I
G
T
G
II
GG
T
LT
A
T
LLAIF
FV
P
LF
F
V
LV
fig|656419.3.peg.1639
Escherichia coli M718 (17-1023/1035)
AI
L
I
M
L
A
G
ILA
I
RT
LPV
A
QYP
D
V
AP
P
T
I
K
I
S
A
T
Y
T
GA
S
A
E
T
L
E
N
S
VT
Q
VIE
QQ
L
TG
L
D
N
L
L
Y
F
SS
T
S
SSD
G
SVS
I
N
V
T
FE
Q
GT
D
PD
T
A
QV
QVQ
NK
I
Q
Q
A
ESR
LP
SEVQQT
GV
TVE-KSQSN
---
F
L
LIA
A
VY
D
TTDKASSS
DI
A
D
W
L
VSN
V
QDP
L
A
RVE
GVG
S
L
QVF
G
AEY-AM
RI
W
LDP
AK
L
A
SYS
L
MPSD
V
QS
AI
EAQ
N
VQVTA
G
K
I
G
A
L
P
SPNTQQLTAT
V
R
A
QSR
LQT
V
D
Q
F
KN
I
I
V
KSQS
DG
AV
V
R
I
K
DVA
R
VE
M
G
S
E
DYTAI
G
KL
NG
H
-
P
S
A
G
VA
V
M
L
SP
GAN
ALN
T
ATL
V
KDK
I
AE
F
QRN
M
P
Q
G
YD
IAYP
K
D
S
T
EF
I
KI
S
V
E
D
VIQT
L
F
EAI
V
LV
V
C
V
M
YLFL
Q
N
L
RATLIP
A
L
AVPV
V
L
L
GTF
G
VL
A
L
F
G
Y
S
I
N
T
LT
L
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
R
D
----------
E
GLP
A
RE
A
TE
K
SMG
E
I
S
G
AL
VAIALV
L
S
AVF
L
PM
A
F
FG
G
ST
G
V
IYR
Q
FSIT
IIS
AM
LL
SV
V
VAL
T
LTP
A
LC
G
SV
L
QHVPPH----KKGFFGAF
N
RF
Y
RRTEDK
----
Y
QRGVI
Y
VL
RRAART
M
G
L
Y
L
V
LGGGMAL
M
MWKL
P
GS
FLP
TE
D
Q
G
EIMVQY
T
L
P
A
G
A
T
AARTAEVNR
Q
IV
D
WF
LINEKAN
T
D
V
I
F
TVD
G
FSFSGSGQ
N
TGMAF
---
V
S
LK
N
WS
Q
-
R
KGAENTAQ
AI
A
L
RA
TKELGTIRDAT
V
F--
A
M
-
TPPA
V
DGL
G
QS
N
GFTFE
L
LANGGTDR
E
T
L
LQMRN
QL
IEK
A
NQS
P
-E
L
HS
V
RA
N
D
L
P
QMPQLQ
V
D
I
D
SN
KA
V
S
L
G
L
SL
N
D
V
TDT
L
S
S
A
W
G
GTY
V
NDFIDRGRV
K
K
V
Y
I
Q
GDSEF
R
SA
P
SD
L
GKWF
V
R
G
SD
N
AMT
P
F
S
AF
A
TTRWLY
G
P
ER
L
VRY
N
GS
A
AYE
I
QG
E
N
ATGF
S
S
G
D
A
MTKMEELANS
L
-
-
P
A
G
TTWA
W
S
G
--
LS
L
Q
EK
L
ASGQALS
L
Y
A
-
V
S
I
L
V
VFL
C
L
AA
LYES
WSV
P
FS
V
I
L
V
I
P
L
G
L
L
G
A
A
LA
AWMR
D
LN
NDV
YFQV
A
L
L
TT
IGL
S
S
KNAILIV
E
FA
-EAA
V
AE
----------
G
YSLS
R
A
ALR
A
AQT
R
L
RPI
I
MT
S
LA
F
I
A
G
V
M
PL
AI
A
T
GAG
A
N
SRIA
I
G
T
G
II
GG
T
LT
A
T
LLAIF
FV
P
LF
F
V
LV
fig|585057.4.peg.1712
Escherichia coli IAI39 (17-1023/1035)
AI
L
I
M
L
A
G
ILA
I
RT
LPV
A
QYP
D
V
AP
P
T
I
K
I
S
A
T
Y
T
GA
S
A
E
T
L
E
N
S
VT
Q
VIE
QQ
L
TG
L
D
N
L
L
Y
F
SS
T
S
SSD
G
SVS
I
N
V
T
FE
Q
GT
D
PD
T
A
QV
QVQ
NK
I
Q
Q
A
ESR
LP
SEVQQT
GV
TVE-KSQSN
---
F
L
LIA
A
VY
D
TTDKASSS
DI
A
D
W
L
VSN
V
QDP
L
A
RVE
GVG
S
L
QVF
G
AEY-AM
RI
W
LDP
AK
L
A
SYS
L
MPSD
V
QS
AI
EAQ
N
VQVTA
G
K
I
G
A
L
P
SPDTQQLTAT
V
R
A
QSR
LQT
V
D
Q
F
KN
I
I
V
KSQS
DG
AV
V
R
I
K
DVA
R
VE
M
G
S
E
DYTAI
G
KL
NG
H
-
P
S
A
G
VA
V
M
L
SP
GAN
ALN
T
ATL
V
KDK
I
AE
F
QRN
M
P
Q
G
YD
IAYP
K
D
S
T
EF
I
KI
S
V
E
D
VIQT
L
F
EAI
V
LV
V
C
V
M
YLFL
Q
N
L
RATLIP
A
L
AVPV
V
L
L
GTF
G
VL
A
L
F
G
Y
S
I
N
T
LT
L
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
R
D
----------
E
GLP
A
RE
A
TE
K
SMG
E
I
S
G
AL
VAIALV
L
S
AVF
L
PM
A
F
FG
G
ST
G
V
IYR
Q
FSIT
IIS
AM
LL
SV
V
VAL
T
LTP
A
LC
G
SV
L
QHVPPH----KKGFFGAF
N
RF
Y
RRTEDK
----
Y
QQGVI
Y
VL
RRAART
M
G
L
Y
V
V
LGGGMAL
M
MWKL
P
GS
FLP
TE
D
Q
G
EIMVQY
T
L
P
A
G
A
T
AARTAEVNR
Q
IV
D
WF
LINEKAN
T
D
V
I
F
TVD
G
FSFSGSGQ
N
TGMAF
---
V
S
LK
N
WS
Q
-
R
KGAENTAQ
AI
A
L
RA
TKELGTIRDAT
V
F--
A
M
-
TPPA
V
DGL
G
QS
N
GFTFE
L
LANGGTDR
E
T
L
LQMRN
QL
IEK
A
NQS
P
-E
L
HS
V
RA
N
D
L
P
QMPQLQ
V
D
I
D
SN
KA
V
S
L
G
L
SL
N
D
V
TDT
L
S
S
A
W
G
GTY
V
NDFIDRGRV
K
K
V
Y
I
Q
GDSEF
R
SA
P
SD
L
GKWF
V
R
G
SD
N
AMT
P
F
S
AF
A
TTRWLY
G
P
ER
L
VRY
N
GS
A
AYE
I
QG
E
N
ATGF
S
S
G
D
A
MTKMEELANS
L
-
-
P
A
G
TTWA
W
S
G
--
LS
L
Q
EK
L
ASGQALS
L
Y
A
-
V
S
I
L
V
VFL
C
L
AA
LYES
WSV
P
FS
V
I
L
V
I
P
L
G
L
L
G
A
A
LA
AWMR
D
LN
NDV
YFQV
A
L
L
TT
IGL
S
S
KNAILIV
E
FA
-EAA
V
AE
----------
G
YSLS
R
A
ALR
A
AQT
R
L
RPI
I
MT
S
LA
F
I
A
G
V
M
PL
AI
A
T
GAG
A
N
SRIA
I
G
T
G
II
GG
T
LT
A
T
LLAIF
FV
P
LF
F
V
LV
fig|585057.6.peg.1712
Escherichia coli IAI39 (17-1023/1035)
AI
L
I
M
L
A
G
ILA
I
RT
LPV
A
QYP
D
V
AP
P
T
I
K
I
S
A
T
Y
T
GA
S
A
E
T
L
E
N
S
VT
Q
VIE
QQ
L
TG
L
D
N
L
L
Y
F
SS
T
S
SSD
G
SVS
I
N
V
T
FE
Q
GT
D
PD
T
A
QV
QVQ
NK
I
Q
Q
A
ESR
LP
SEVQQT
GV
TVE-KSQSN
---
F
L
LIA
A
VY
D
TTDKASSS
DI
A
D
W
L
VSN
V
QDP
L
A
RVE
GVG
S
L
QVF
G
AEY-AM
RI
W
LDP
AK
L
A
SYS
L
MPSD
V
QS
AI
EAQ
N
VQVTA
G
K
I
G
A
L
P
SPDTQQLTAT
V
R
A
QSR
LQT
V
D
Q
F
KN
I
I
V
KSQS
DG
AV
V
R
I
K
DVA
R
VE
M
G
S
E
DYTAI
G
KL
NG
H
-
P
S
A
G
VA
V
M
L
SP
GAN
ALN
T
ATL
V
KDK
I
AE
F
QRN
M
P
Q
G
YD
IAYP
K
D
S
T
EF
I
KI
S
V
E
D
VIQT
L
F
EAI
V
LV
V
C
V
M
YLFL
Q
N
L
RATLIP
A
L
AVPV
V
L
L
GTF
G
VL
A
L
F
G
Y
S
I
N
T
LT
L
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
R
D
----------
E
GLP
A
RE
A
TE
K
SMG
E
I
S
G
AL
VAIALV
L
S
AVF
L
PM
A
F
FG
G
ST
G
V
IYR
Q
FSIT
IIS
AM
LL
SV
V
VAL
T
LTP
A
LC
G
SV
L
QHVPPH----KKGFFGAF
N
RF
Y
RRTEDK
----
Y
QQGVI
Y
VL
RRAART
M
G
L
Y
V
V
LGGGMAL
M
MWKL
P
GS
FLP
TE
D
Q
G
EIMVQY
T
L
P
A
G
A
T
AARTAEVNR
Q
IV
D
WF
LINEKAN
T
D
V
I
F
TVD
G
FSFSGSGQ
N
TGMAF
---
V
S
LK
N
WS
Q
-
R
KGAENTAQ
AI
A
L
RA
TKELGTIRDAT
V
F--
A
M
-
TPPA
V
DGL
G
QS
N
GFTFE
L
LANGGTDR
E
T
L
LQMRN
QL
IEK
A
NQS
P
-E
L
HS
V
RA
N
D
L
P
QMPQLQ
V
D
I
D
SN
KA
V
S
L
G
L
SL
N
D
V
TDT
L
S
S
A
W
G
GTY
V
NDFIDRGRV
K
K
V
Y
I
Q
GDSEF
R
SA
P
SD
L
GKWF
V
R
G
SD
N
AMT
P
F
S
AF
A
TTRWLY
G
P
ER
L
VRY
N
GS
A
AYE
I
QG
E
N
ATGF
S
S
G
D
A
MTKMEELANS
L
-
-
P
A
G
TTWA
W
S
G
--
LS
L
Q
EK
L
ASGQALS
L
Y
A
-
V
S
I
L
V
VFL
C
L
AA
LYES
WSV
P
FS
V
I
L
V
I
P
L
G
L
L
G
A
A
LA
AWMR
D
LN
NDV
YFQV
A
L
L
TT
IGL
S
S
KNAILIV
E
FA
-EAA
V
AE
----------
G
YSLS
R
A
ALR
A
AQT
R
L
RPI
I
MT
S
LA
F
I
A
G
V
M
PL
AI
A
T
GAG
A
N
SRIA
I
G
T
G
II
GG
T
LT
A
T
LLAIF
FV
P
LF
F
V
LV
fig|670897.3.peg.2458
Escherichia coli 2362-75 (17-1023/1035)
AI
L
I
M
L
A
G
ILA
I
RT
LPV
A
QYP
D
V
AP
P
T
I
K
I
S
A
T
Y
T
GA
S
A
E
T
L
E
N
S
VT
Q
VIE
QQ
L
TG
L
D
N
L
L
Y
F
SS
T
S
SSD
G
SVS
I
N
V
T
FE
Q
GT
D
PD
T
A
QV
QVQ
NK
I
Q
Q
A
ESR
LP
SEVQQT
GV
TVE-KSQSN
---
F
L
LIA
A
VY
D
TTDKASSS
DI
A
D
W
L
VSN
V
QDP
L
A
RVE
GVG
S
L
QVF
G
AEY-AM
RI
W
LDP
AK
L
A
SYS
L
MPSD
V
QS
AI
EAQ
N
VQVTA
G
K
I
G
A
L
P
SPDTQQLTAT
V
R
A
QSR
LQT
V
D
Q
F
KN
I
I
V
KSQS
DG
AV
V
R
I
K
DVA
R
VE
M
G
S
E
DYTAI
G
KL
NG
H
-
P
S
A
G
VA
V
M
L
SP
GAN
ALN
T
ATL
V
KDK
I
AE
F
QRN
M
P
Q
G
YD
IAYP
K
D
S
T
EF
I
KI
S
V
E
D
VIQT
L
F
EAI
V
LV
V
C
V
M
YLFL
Q
N
L
RATLIP
A
L
AVPV
V
L
L
GTF
G
VL
A
L
F
G
Y
S
I
N
T
LT
L
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
R
D
----------
E
GLP
A
RE
A
TE
K
SMG
E
I
S
G
AL
VAIALV
L
S
AVF
L
PM
A
F
FG
G
ST
G
V
IYR
Q
FSIT
IIS
AM
LL
SV
V
VAL
T
LTP
A
LC
G
SV
L
QHVPPH----KKGFFGAF
N
RF
Y
RRTEDK
----
Y
QRGVI
Y
VL
RRAART
M
G
L
Y
V
V
LGGGMAL
M
MWKL
P
GS
FLP
TE
D
Q
G
EIMVQY
T
L
P
A
G
A
T
AARTAEVNR
Q
IV
D
WF
LINEKAN
T
D
V
I
F
TVD
G
FSFSGSGQ
N
TGMAF
---
V
S
LK
N
WS
Q
-
R
KGAENTAQ
AI
A
L
RA
TKELGTIRDAT
V
F--
A
M
-
TPPA
V
DGL
G
QS
N
GFTFE
L
LANGGTDR
E
T
L
LQMRN
QL
IEK
A
NQS
P
-E
L
HS
V
RA
N
D
L
P
QMPQLQ
V
D
I
D
SN
KA
V
S
L
G
L
SL
N
D
V
TDT
L
S
S
A
W
G
GTY
V
NDFIDRGRV
K
K
V
Y
I
Q
GDSEF
R
SA
P
SD
L
GKWF
V
R
G
SD
N
AMT
P
F
S
AF
A
TTRWLY
G
P
ER
L
VRY
N
GS
A
AYE
I
QG
E
N
ATGF
S
S
G
D
A
MTKMEELANS
L
-
-
P
A
G
TTWA
W
S
G
--
LS
L
Q
EK
L
ASGQALS
L
Y
A
-
V
S
I
L
V
VFL
C
L
AA
LYES
WSV
P
FS
V
I
L
V
I
P
L
G
L
L
G
A
A
LA
AWMR
D
LN
NDV
YFQV
A
L
L
TT
IGL
S
S
KNAILIV
E
FA
-EAA
V
AE
----------
G
YSLS
R
A
ALR
A
AQT
R
L
RPI
I
MT
S
LA
F
I
A
G
V
M
PL
AI
A
T
GAG
A
N
SRIA
I
G
T
G
II
GG
T
LT
A
T
LLAIF
FV
P
LF
F
V
LV
fig|753642.3.peg.1821
Escherichia coli NC101 (17-1023/1035)
AI
L
I
M
L
A
G
ILA
I
RT
LPV
A
QYP
D
V
AP
P
T
I
K
I
S
A
T
Y
T
GA
S
A
E
T
L
E
N
S
VT
Q
VIE
QQ
L
TG
L
D
N
L
L
Y
F
SS
T
S
SSD
G
SVS
I
N
V
T
FE
Q
GT
D
PD
T
A
QV
QVQ
NK
I
Q
Q
A
ESR
LP
SEVQQT
GV
TVE-KSQSN
---
F
L
LIA
A
VY
D
TTDKASSS
DI
A
D
W
L
VSN
V
QDP
L
A
RVE
GVG
S
L
QVF
G
AEY-AM
RI
W
LDP
AK
L
A
SYS
L
MPSD
V
QS
AI
EAQ
N
VQVTA
G
K
I
G
A
L
P
SPDTQQLTAT
V
R
A
QSR
LQT
V
D
Q
F
KN
I
I
V
KSQS
DG
AV
V
R
I
K
DVA
R
VE
M
G
S
E
DYTAI
G
KL
NG
H
-
P
S
A
G
VA
V
M
L
SP
GAN
ALN
T
ATL
V
KDK
I
AE
F
QRN
M
P
Q
G
YD
IAYP
K
D
S
T
EF
I
KI
S
V
E
D
VIQT
L
F
EAI
V
LV
V
C
V
M
YLFL
Q
N
L
RATLIP
A
L
AVPV
V
L
L
GTF
G
VL
A
L
F
G
Y
S
I
N
T
LT
L
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
R
D
----------
E
GLP
A
RE
A
TE
K
SMG
E
I
S
G
AL
VAIALV
L
S
AVF
L
PM
A
F
FG
G
ST
G
V
IYR
Q
FSIT
IIS
AM
LL
SV
V
VAL
T
LTP
A
LC
G
SV
L
QHVPPH----KKGFFGAF
N
RF
Y
RRTEDK
----
Y
QRGVI
Y
VL
RRAART
M
G
L
Y
V
V
LGGGMAL
M
MWKL
P
GS
FLP
TE
D
Q
G
EIMVQY
T
L
P
A
G
A
T
AARTAEVNR
Q
IV
D
WF
LINEKAN
T
D
V
I
F
TVD
G
FSFSGSGQ
N
TGMAF
---
V
S
LK
N
WS
Q
-
R
KGAENTAQ
AI
A
L
RA
TKELGTIRDAT
V
F--
A
M
-
TPPA
V
DGL
G
QS
N
GFTFE
L
LANGGTDR
E
T
L
LQMRN
QL
IEK
A
NQS
P
-E
L
HS
V
RA
N
D
L
P
QMPQLQ
V
D
I
D
SN
KA
V
S
L
G
L
SL
N
D
V
TDT
L
S
S
A
W
G
GTY
V
NDFIDRGRV
K
K
V
Y
I
Q
GDSEF
R
SA
P
SD
L
GKWF
V
R
G
SD
N
AMT
P
F
S
AF
A
TTRWLY
G
P
ER
L
VRY
N
GS
A
AYE
I
QG
E
N
ATGF
S
S
G
D
A
MTKMEELANS
L
-
-
P
A
G
TTWA
W
S
G
--
LS
L
Q
EK
L
ASGQALS
L
Y
A
-
V
S
I
L
V
VFL
C
L
AA
LYES
WSV
P
FS
V
I
L
V
I
P
L
G
L
L
G
A
A
LA
AWMR
D
LN
NDV
YFQV
A
L
L
TT
IGL
S
S
KNAILIV
E
FA
-EAA
V
AE
----------
G
YSLS
R
A
ALR
A
AQT
R
L
RPI
I
MT
S
LA
F
I
A
G
V
M
PL
AI
A
T
GAG
A
N
SRIA
I
G
T
G
II
GG
T
LT
A
T
LLAIF
FV
P
LF
F
V
LV
fig|431946.3.peg.1319
Escherichia coli SE15 (17-1023/1035)
AI
L
I
M
L
A
G
ILA
I
RT
LPV
A
QYP
D
V
AP
P
T
I
K
I
S
A
T
Y
T
GA
S
A
E
T
L
E
N
S
VT
Q
VIE
QQ
L
TG
L
D
N
L
L
Y
F
SS
T
S
SSD
G
SVS
I
N
V
T
FE
Q
GT
D
PD
T
A
QV
QVQ
NK
I
Q
Q
A
ESR
LP
SEVQQT
GV
TVE-KSQSN
---
F
L
LIA
A
VY
D
TTDKASSS
DI
A
D
W
L
VSN
V
QDP
L
A
RVE
GVG
S
L
QVF
G
AEY-AM
RI
W
LDP
AK
L
A
SYS
L
MPSD
V
QS
AI
EAQ
N
VQVTA
G
K
I
G
A
L
P
SPDTQQLTAT
V
R
A
QSR
LQT
V
D
Q
F
KN
I
I
V
KSQS
DG
AV
V
R
I
K
DVA
R
VE
M
G
S
E
DYTAI
G
KL
NG
H
-
P
S
A
G
VA
V
M
L
SP
GAN
ALN
T
ATL
V
KDK
I
AE
F
QRN
M
P
Q
G
YD
IAYP
K
D
S
T
EF
I
KI
S
V
E
D
VIQT
L
F
EAI
V
LV
V
C
V
M
YLFL
Q
N
L
RATLIP
A
L
AVPV
V
L
L
GTF
G
VL
A
L
F
G
Y
S
I
N
T
LT
L
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
R
D
----------
E
GLP
A
RE
A
TE
K
SMG
E
I
S
G
AL
VAIALV
L
S
AVF
L
PM
A
F
FG
G
ST
G
V
IYR
Q
FSIT
IIS
AM
LL
SV
V
VAL
T
LTP
A
LC
G
SV
L
QHVPPH----KKGFFGAF
N
RF
Y
RRTEDK
----
Y
QRGVI
Y
VL
RRAART
M
G
L
Y
V
V
LGGGMAL
M
MWKL
P
GS
FLP
TE
D
Q
G
EIMVQY
T
L
P
A
G
A
T
AARTAEVNR
Q
IV
D
WF
LINEKAN
T
D
V
I
F
TVD
G
FSFSGSGQ
N
TGMAF
---
V
S
LK
N
WS
Q
-
R
KGAENTAQ
AI
A
L
RA
TKELGTIRDAT
V
F--
A
M
-
TPPA
V
DGL
G
QS
N
GFTFE
L
LANGGTDR
E
T
L
LQMRN
QL
IEK
A
NQS
P
-E
L
HS
V
RA
N
D
L
P
QMPQLQ
V
D
I
D
SN
KA
V
S
L
G
L
SL
N
D
V
TDT
L
S
S
A
W
G
GTY
V
NDFIDRGRV
K
K
V
Y
I
Q
GDSEF
R
SA
P
SD
L
GKWF
V
R
G
SD
N
AMT
P
F
S
AF
A
TTRWLY
G
P
ER
L
VRY
N
GS
A
AYE
I
QG
E
N
ATGF
S
S
G
D
A
MTKMEELANS
L
-
-
P
A
G
TTWA
W
S
G
--
LS
L
Q
EK
L
ASGQALS
L
Y
A
-
V
S
I
L
V
VFL
C
L
AA
LYES
WSV
P
FS
V
I
L
V
I
P
L
G
L
L
G
A
A
LA
AWMR
D
LN
NDV
YFQV
A
L
L
TT
IGL
S
S
KNAILIV
E
FA
-EAA
V
AE
----------
G
YSLS
R
A
ALR
A
AQT
R
L
RPI
I
MT
S
LA
F
I
A
G
V
M
PL
AI
A
T
GAG
A
N
SRIA
I
G
T
G
II
GG
T
LT
A
T
LLAIF
FV
P
LF
F
V
LV
fig|749531.3.peg.294
Escherichia coli MS 69-1 (17-1023/1035)
AI
L
I
M
L
A
G
ILA
I
RT
LPV
A
QYP
D
V
AP
P
T
I
K
I
S
A
T
Y
T
GA
S
A
E
T
L
E
N
S
VT
Q
VIE
QQ
L
TG
L
D
N
L
L
Y
F
SS
T
S
SSD
G
SVS
I
N
V
T
FE
Q
GT
D
PD
T
A
QV
QVQ
NK
I
Q
Q
A
ESR
LP
SEVQQT
GV
TVE-KSQSN
---
F
L
LIA
A
VY
D
TTDKASSS
DI
A
D
W
L
VSN
V
QDP
L
A
RVE
GVG
S
L
QVF
G
AEY-AM
RI
W
LDP
AK
L
A
SYS
L
MPSD
V
QS
AI
EAQ
N
VQVTA
G
K
I
G
A
L
P
SPNTQQLTAT
V
R
A
QSR
LQT
V
D
Q
F
KN
I
I
V
KSQS
DG
AV
V
R
I
K
DVA
R
VE
M
G
S
E
DYTAI
G
KL
NG
H
-
P
S
A
G
VA
V
M
L
SP
GAN
ALN
T
ATL
V
KDK
I
AE
F
QRN
M
P
Q
G
YD
IAYP
K
D
S
T
EF
I
KI
S
V
E
D
VIQT
L
F
EAI
V
LV
V
C
V
M
YLFL
Q
N
L
RATLIP
A
L
AVPV
V
L
L
GTF
G
VL
A
L
F
G
Y
S
I
N
T
LT
L
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
R
D
----------
E
GLP
A
RE
A
TE
K
SMG
E
I
S
G
AL
VAIALV
L
S
AVF
L
PM
A
F
FG
G
ST
G
V
IYR
Q
FSIT
IIS
AM
LL
SV
V
VAL
T
LTP
A
LC
G
SV
L
QHVPPH----KKGFFGAF
N
RF
Y
RRTEDK
----
Y
QRGVI
Y
VL
RRAART
M
G
L
Y
V
V
LGGGMAL
M
MWKL
P
GS
FLP
TE
D
Q
G
EIMVQY
T
L
P
A
G
A
T
AARTAEVNR
Q
IV
D
WF
LINEKAN
T
D
V
I
F
TVD
G
FSFSGSGQ
N
TGMAF
---
V
S
LK
N
WS
Q
-
R
KGAENTAQ
AI
A
L
RA
TKELGTIRDAT
V
F--
A
M
-
TPPA
V
DGL
G
QS
N
GFTFE
L
LANGGTDR
E
T
L
LQMRN
QL
IEK
A
NQS
P
-E
L
HS
V
RA
N
D
L
P
QMPQLQ
V
D
I
D
SN
KA
V
S
L
G
L
SL
N
D
V
TDT
L
S
S
A
W
G
GTY
V
NDFIDRGRV
K
K
V
Y
I
Q
GDSEF
R
ST
P
SD
L
GKWF
V
R
G
SD
N
AMT
L
F
S
AF
A
TTRWLY
G
P
ER
L
VRY
N
GS
A
AYE
I
QG
E
N
ATGF
S
S
G
D
A
MTKMEELANS
L
-
-
P
A
G
TTWA
W
S
G
--
LS
L
Q
EK
L
ASGQALS
L
Y
A
-
V
S
I
L
V
VFL
C
L
AA
LYES
WSV
P
FS
V
I
L
V
I
P
L
G
L
L
G
A
A
LA
AWMR
D
LN
NDV
YFQV
A
L
L
TT
IGL
S
S
KNAILIV
E
FA
-EAA
V
AE
----------
G
YSLS
R
A
ALR
A
AQT
R
L
RPI
I
MT
S
LA
F
I
A
G
V
M
PL
AI
A
T
GAG
A
N
SRIA
I
G
T
G
II
GG
T
LT
A
T
LLAIF
FV
P
LF
F
V
LV
fig|749527.3.peg.410
Escherichia coli MS 21-1 (17-1023/1035)
AI
L
I
M
L
A
G
ILA
I
RT
LPV
A
QYP
D
V
AP
P
T
I
K
I
S
A
T
Y
T
GA
S
A
E
T
L
E
N
S
VT
Q
VIE
QQ
L
TG
L
D
N
L
L
Y
F
SS
T
S
SSD
G
SVS
I
N
V
T
FE
Q
GT
D
PD
T
A
QV
QVQ
NK
I
Q
Q
A
ESR
LP
SEVQQT
GV
TVE-KSQSN
---
F
L
LIA
A
VY
D
TTDKASSS
DI
A
D
W
L
VSN
V
QDP
L
A
RVE
GVG
S
L
QVF
G
AEY-AM
RI
W
LDP
AK
L
A
SYS
L
MPSD
V
QS
AI
EAQ
N
VQVTA
G
K
I
G
A
L
P
SPNTQQLTAT
V
R
A
QSR
LQT
V
D
Q
F
KN
I
I
V
KSQS
DG
AV
V
R
I
K
DVA
R
VE
M
G
S
E
DYTAI
G
KL
NG
H
-
P
S
A
G
VA
V
M
L
SP
GAN
ALN
T
ATL
V
KDK
I
AE
F
QRN
M
P
Q
G
YD
IAYP
K
D
S
T
EF
I
KI
S
V
E
D
VIQT
L
F
EAI
V
LV
V
C
V
M
YLFL
Q
N
L
RATLIP
A
L
AVPV
V
L
L
GTF
G
VL
A
L
F
G
Y
S
I
N
T
LT
L
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
R
D
----------
E
GLP
A
RE
A
TE
K
SMG
E
I
S
G
AL
VAIALV
L
S
AVF
L
PM
A
F
FG
G
ST
G
V
IYR
Q
FSIT
IIS
AM
LL
SV
V
VAL
T
LTP
A
LC
G
SV
L
QHVPPH----KKGFFGAF
N
RF
Y
RRTEDK
----
Y
QRGVI
Y
VL
RRAART
M
G
L
Y
V
V
LGGGMAL
M
MWKL
P
GS
FLP
TE
D
Q
G
EIMVQY
T
L
P
A
G
A
T
AARTAEVNR
Q
IV
D
WF
LINEKAN
T
D
V
I
F
TVD
G
FSFSGSGQ
N
TGMAF
---
V
S
LK
N
WS
Q
-
R
KGTENTAQ
AI
A
L
RA
TKELGTIRDAT
V
F--
A
M
-
TPPA
V
DGL
G
QS
N
GFTFE
L
LANGGTDR
E
T
L
LQMRN
QL
IEK
A
NQS
P
-E
L
HS
V
RA
N
D
L
P
QMPQLQ
V
D
I
D
SN
KA
V
S
L
G
L
SL
N
D
V
TDT
L
S
S
A
W
G
GTY
V
NDFIDRGRV
K
K
V
Y
I
Q
GDSEF
R
SA
P
SD
L
GKWF
V
R
G
SD
N
AMT
P
F
S
AF
A
TTRWLY
G
P
ER
L
VRY
N
GS
A
AYE
I
QG
E
N
ATGF
S
S
G
D
A
MTKMEELANS
L
-
-
P
A
G
TTWA
W
S
G
--
LS
L
Q
EK
L
ASGQALS
L
Y
A
-
V
S
I
L
V
VFL
C
L
AA
LYES
WSV
P
FS
V
I
L
V
I
P
L
G
L
L
G
A
A
LA
AWMR
D
LN
NDV
YFQV
A
L
L
TT
IGL
S
S
KNAILIV
E
FA
-EAA
V
AE
----------
G
YSLS
R
A
ALR
A
AQT
R
L
RPI
I
MT
S
LA
F
I
A
G
V
M
PL
AI
A
T
GAG
A
N
SRIA
I
G
T
G
II
GG
T
LT
A
T
LLAIF
FV
P
LF
F
V
LV
fig|362663.8.peg.1356
Escherichia coli 536 (17-1023/1035)
AI
L
I
M
L
A
G
ILA
I
RT
LPV
A
QYP
D
V
AP
P
T
I
K
I
S
A
T
Y
T
GA
S
A
E
T
L
E
N
S
VT
Q
VIE
QQ
L
TG
L
D
N
L
L
Y
F
SS
T
S
SSD
G
SVS
I
N
V
T
FE
Q
GT
D
PD
T
A
QV
QVQ
NK
I
Q
Q
A
ESR
LP
SEVQQT
GV
TVE-KSQSN
---
F
L
LIA
A
VY
D
TTDKASSS
DI
A
D
W
L
VSN
V
QDP
L
A
RVE
GVG
S
L
QVF
G
AEY-AM
RI
W
LDP
AK
L
A
SYS
L
MPSD
V
QS
AI
EAQ
N
VQVTA
G
K
I
G
A
L
P
SPNTQQLTAT
V
R
A
QSR
LQT
V
D
Q
F
KN
I
I
V
KSQS
DG
AV
V
R
I
K
DVA
R
VE
M
G
S
E
DYTAI
G
KL
NG
H
-
P
S
A
G
VA
V
M
L
SP
GAN
ALN
T
ATL
V
KDK
I
AE
F
QRN
M
P
Q
G
YD
IAYP
K
D
S
T
EF
I
KI
S
V
E
D
VIQT
L
F
EAI
V
LV
V
C
V
M
YLFL
Q
N
L
RATLIP
A
L
AVPV
V
L
L
GTF
G
VL
A
L
F
G
Y
S
I
N
T
LT
L
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
R
D
----------
E
GLP
A
RE
A
TE
K
SMG
E
I
S
G
AL
VAIALV
L
S
AVF
L
PM
A
F
FG
G
ST
G
V
IYR
Q
FSIT
IIS
AM
LL
SV
V
VAL
T
LTP
A
LC
G
SV
L
QHVPPH----KKGFFGAF
N
RF
Y
RRTEDK
----
Y
QRGVI
Y
VL
RRAART
M
G
L
Y
V
V
LGGGMAL
M
MWKL
P
GS
FLP
TE
D
Q
G
EIMVQY
T
L
P
A
G
A
T
AARTAEVNR
Q
IV
D
WF
LINEKAN
T
D
V
I
F
TVD
G
FSFSGSGQ
N
TGMAF
---
V
S
LK
N
WS
Q
-
R
KGAENTAQ
AI
A
L
RA
TKELGTIRDAT
V
F--
A
M
-
TPPA
V
DGL
G
QS
N
GFTFE
L
LANGGTDR
E
T
L
LQMRN
QL
IEK
A
NQS
P
-E
L
HS
V
RA
N
D
L
P
QMPQLQ
V
D
I
D
SN
KA
V
S
L
G
L
SL
N
D
V
TDT
L
S
S
A
W
G
GTY
V
NDFIDRGRV
K
K
V
Y
I
Q
GDSEF
R
SA
P
SD
L
GKWF
V
R
G
SD
N
AMT
P
F
S
AF
A
TTRWLY
G
P
ER
L
VRY
N
GS
A
AYE
I
QG
E
N
ATGF
S
S
G
D
A
MTKMEELANS
L
-
-
P
A
G
TTWA
W
S
G
--
LS
L
Q
EK
L
ASGQALS
L
Y
A
-
V
S
I
L
V
VFL
C
L
AA
LYES
WSV
P
FS
V
I
L
V
I
P
L
G
L
L
G
A
A
LA
AWMR
D
LN
NDV
YFQV
A
L
L
TT
IGL
S
S
KNAILIV
E
FA
-EAA
V
AE
----------
G
YSLS
R
A
ALR
A
AQT
R
L
RPI
I
MT
S
LA
F
I
A
G
V
M
PL
AI
A
T
GAG
A
N
SRIA
I
G
T
G
II
GG
T
LT
A
T
LLAIF
FV
P
LF
F
V
LV
fig|362663.9.peg.1356
Escherichia coli 536 (17-1023/1035)
AI
L
I
M
L
A
G
ILA
I
RT
LPV
A
QYP
D
V
AP
P
T
I
K
I
S
A
T
Y
T
GA
S
A
E
T
L
E
N
S
VT
Q
VIE
QQ
L
TG
L
D
N
L
L
Y
F
SS
T
S
SSD
G
SVS
I
N
V
T
FE
Q
GT
D
PD
T
A
QV
QVQ
NK
I
Q
Q
A
ESR
LP
SEVQQT
GV
TVE-KSQSN
---
F
L
LIA
A
VY
D
TTDKASSS
DI
A
D
W
L
VSN
V
QDP
L
A
RVE
GVG
S
L
QVF
G
AEY-AM
RI
W
LDP
AK
L
A
SYS
L
MPSD
V
QS
AI
EAQ
N
VQVTA
G
K
I
G
A
L
P
SPNTQQLTAT
V
R
A
QSR
LQT
V
D
Q
F
KN
I
I
V
KSQS
DG
AV
V
R
I
K
DVA
R
VE
M
G
S
E
DYTAI
G
KL
NG
H
-
P
S
A
G
VA
V
M
L
SP
GAN
ALN
T
ATL
V
KDK
I
AE
F
QRN
M
P
Q
G
YD
IAYP
K
D
S
T
EF
I
KI
S
V
E
D
VIQT
L
F
EAI
V
LV
V
C
V
M
YLFL
Q
N
L
RATLIP
A
L
AVPV
V
L
L
GTF
G
VL
A
L
F
G
Y
S
I
N
T
LT
L
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
R
D
----------
E
GLP
A
RE
A
TE
K
SMG
E
I
S
G
AL
VAIALV
L
S
AVF
L
PM
A
F
FG
G
ST
G
V
IYR
Q
FSIT
IIS
AM
LL
SV
V
VAL
T
LTP
A
LC
G
SV
L
QHVPPH----KKGFFGAF
N
RF
Y
RRTEDK
----
Y
QRGVI
Y
VL
RRAART
M
G
L
Y
V
V
LGGGMAL
M
MWKL
P
GS
FLP
TE
D
Q
G
EIMVQY
T
L
P
A
G
A
T
AARTAEVNR
Q
IV
D
WF
LINEKAN
T
D
V
I
F
TVD
G
FSFSGSGQ
N
TGMAF
---
V
S
LK
N
WS
Q
-
R
KGAENTAQ
AI
A
L
RA
TKELGTIRDAT
V
F--
A
M
-
TPPA
V
DGL
G
QS
N
GFTFE
L
LANGGTDR
E
T
L
LQMRN
QL
IEK
A
NQS
P
-E
L
HS
V
RA
N
D
L
P
QMPQLQ
V
D
I
D
SN
KA
V
S
L
G
L
SL
N
D
V
TDT
L
S
S
A
W
G
GTY
V
NDFIDRGRV
K
K
V
Y
I
Q
GDSEF
R
SA
P
SD
L
GKWF
V
R
G
SD
N
AMT
P
F
S
AF
A
TTRWLY
G
P
ER
L
VRY
N
GS
A
AYE
I
QG
E
N
ATGF
S
S
G
D
A
MTKMEELANS
L
-
-
P
A
G
TTWA
W
S
G
--
LS
L
Q
EK
L
ASGQALS
L
Y
A
-
V
S
I
L
V
VFL
C
L
AA
LYES
WSV
P
FS
V
I
L
V
I
P
L
G
L
L
G
A
A
LA
AWMR
D
LN
NDV
YFQV
A
L
L
TT
IGL
S
S
KNAILIV
E
FA
-EAA
V
AE
----------
G
YSLS
R
A
ALR
A
AQT
R
L
RPI
I
MT
S
LA
F
I
A
G
V
M
PL
AI
A
T
GAG
A
N
SRIA
I
G
T
G
II
GG
T
LT
A
T
LLAIF
FV
P
LF
F
V
LV
fig|525281.3.peg.128
Escherichia coli 83972 (17-1023/1035)
AI
L
I
M
L
A
G
ILA
I
RT
LPV
A
QYP
D
V
AP
P
T
I
K
I
S
A
T
Y
T
GA
S
A
E
T
L
E
N
S
VT
Q
VIE
QQ
L
TG
L
D
N
L
L
Y
F
SS
T
S
SSD
G
SVS
I
N
V
T
FE
Q
GT
D
PD
T
A
QV
QVQ
NK
I
Q
Q
A
ESR
LP
SEVQQT
GV
TVE-KSQSN
---
F
L
LIA
A
VY
D
TTDKASSS
DI
A
D
W
L
VSN
V
QDP
L
A
RVE
GVG
S
L
QVF
G
AEY-AM
RI
W
LDP
AK
L
A
SYS
L
MPSD
V
QS
AI
EAQ
N
VQVTA
G
K
I
G
A
L
P
SPNTQQLTAT
V
R
A
QSR
LQT
V
D
Q
F
KN
I
I
V
KSQS
DG
AV
V
R
I
K
DVA
R
VE
M
G
S
E
DYTAI
G
KL
NG
H
-
P
S
A
G
VA
V
M
L
SP
GAN
ALN
T
ATL
V
KDK
I
AE
F
QRN
M
P
Q
G
YD
IAYP
K
D
S
T
EF
I
KI
S
V
E
D
VIQT
L
F
EAI
V
LV
V
C
V
M
YLFL
Q
N
L
RATLIP
A
L
AVPV
V
L
L
GTF
G
VL
A
L
F
G
Y
S
I
N
T
LT
L
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
R
D
----------
E
GLP
A
RE
A
TE
K
SMG
E
I
S
G
AL
VAIALV
L
S
AVF
L
PM
A
F
FG
G
ST
G
V
IYR
Q
FSIT
IIS
AM
LL
SV
V
VAL
T
LTP
A
LC
G
SV
L
QHVPPH----KKGFFGAF
N
RF
Y
RRTEDK
----
Y
QRGVI
Y
VL
RRAART
M
G
L
Y
V
V
LGGGMAL
M
MWKL
P
GS
FLP
TE
D
Q
G
EIMVQY
T
L
P
A
G
A
T
AARTAEVNR
Q
IV
D
WF
LINEKAN
T
D
V
I
F
TVD
G
FSFSGSGQ
N
TGMAF
---
V
S
LK
N
WS
Q
-
R
KGAENTAQ
AI
A
L
RA
TKELGTIRDAT
V
F--
A
M
-
TPPA
V
DGL
G
QS
N
GFTFE
L
LANGGTDR
E
T
L
LQMRN
QL
IEK
A
NQS
P
-E
L
HS
V
RA
N
D
L
P
QMPQLQ
V
D
I
D
SN
KA
V
S
L
G
L
SL
N
D
V
TDT
L
S
S
A
W
G
GTY
V
NDFIDRGRV
K
K
V
Y
I
Q
GDSEF
R
SA
P
SD
L
GKWF
V
R
G
SD
N
AMT
P
F
S
AF
A
TTRWLY
G
P
ER
L
VRY
N
GS
A
AYE
I
QG
E
N
ATGF
S
S
G
D
A
MTKMEELANS
L
-
-
P
A
G
TTWA
W
S
G
--
LS
L
Q
EK
L
ASGQALS
L
Y
A
-
V
S
I
L
V
VFL
C
L
AA
LYES
WSV
P
FS
V
I
L
V
I
P
L
G
L
L
G
A
A
LA
AWMR
D
LN
NDV
YFQV
A
L
L
TT
IGL
S
S
KNAILIV
E
FA
-EAA
V
AE
----------
G
YSLS
R
A
ALR
A
AQT
R
L
RPI
I
MT
S
LA
F
I
A
G
V
M
PL
AI
A
T
GAG
A
N
SRIA
I
G
T
G
II
GG
T
LT
A
T
LLAIF
FV
P
LF
F
V
LV
fig|655817.3.peg.1652
Escherichia coli ABU 83972 (17-1023/1035)
AI
L
I
M
L
A
G
ILA
I
RT
LPV
A
QYP
D
V
AP
P
T
I
K
I
S
A
T
Y
T
GA
S
A
E
T
L
E
N
S
VT
Q
VIE
QQ
L
TG
L
D
N
L
L
Y
F
SS
T
S
SSD
G
SVS
I
N
V
T
FE
Q
GT
D
PD
T
A
QV
QVQ
NK
I
Q
Q
A
ESR
LP
SEVQQT
GV
TVE-KSQSN
---
F
L
LIA
A
VY
D
TTDKASSS
DI
A
D
W
L
VSN
V
QDP
L
A
RVE
GVG
S
L
QVF
G
AEY-AM
RI
W
LDP
AK
L
A
SYS
L
MPSD
V
QS
AI
EAQ
N
VQVTA
G
K
I
G
A
L
P
SPNTQQLTAT
V
R
A
QSR
LQT
V
D
Q
F
KN
I
I
V
KSQS
DG
AV
V
R
I
K
DVA
R
VE
M
G
S
E
DYTAI
G
KL
NG
H
-
P
S
A
G
VA
V
M
L
SP
GAN
ALN
T
ATL
V
KDK
I
AE
F
QRN
M
P
Q
G
YD
IAYP
K
D
S
T
EF
I
KI
S
V
E
D
VIQT
L
F
EAI
V
LV
V
C
V
M
YLFL
Q
N
L
RATLIP
A
L
AVPV
V
L
L
GTF
G
VL
A
L
F
G
Y
S
I
N
T
LT
L
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
R
D
----------
E
GLP
A
RE
A
TE
K
SMG
E
I
S
G
AL
VAIALV
L
S
AVF
L
PM
A
F
FG
G
ST
G
V
IYR
Q
FSIT
IIS
AM
LL
SV
V
VAL
T
LTP
A
LC
G
SV
L
QHVPPH----KKGFFGAF
N
RF
Y
RRTEDK
----
Y
QRGVI
Y
VL
RRAART
M
G
L
Y
V
V
LGGGMAL
M
MWKL
P
GS
FLP
TE
D
Q
G
EIMVQY
T
L
P
A
G
A
T
AARTAEVNR
Q
IV
D
WF
LINEKAN
T
D
V
I
F
TVD
G
FSFSGSGQ
N
TGMAF
---
V
S
LK
N
WS
Q
-
R
KGAENTAQ
AI
A
L
RA
TKELGTIRDAT
V
F--
A
M
-
TPPA
V
DGL
G
QS
N
GFTFE
L
LANGGTDR
E
T
L
LQMRN
QL
IEK
A
NQS
P
-E
L
HS
V
RA
N
D
L
P
QMPQLQ
V
D
I
D
SN
KA
V
S
L
G
L
SL
N
D
V
TDT
L
S
S
A
W
G
GTY
V
NDFIDRGRV
K
K
V
Y
I
Q
GDSEF
R
SA
P
SD
L
GKWF
V
R
G
SD
N
AMT
P
F
S
AF
A
TTRWLY
G
P
ER
L
VRY
N
GS
A
AYE
I
QG
E
N
ATGF
S
S
G
D
A
MTKMEELANS
L
-
-
P
A
G
TTWA
W
S
G
--
LS
L
Q
EK
L
ASGQALS
L
Y
A
-
V
S
I
L
V
VFL
C
L
AA
LYES
WSV
P
FS
V
I
L
V
I
P
L
G
L
L
G
A
A
LA
AWMR
D
LN
NDV
YFQV
A
L
L
TT
IGL
S
S
KNAILIV
E
FA
-EAA
V
AE
----------
G
YSLS
R
A
ALR
A
AQT
R
L
RPI
I
MT
S
LA
F
I
A
G
V
M
PL
AI
A
T
GAG
A
N
SRIA
I
G
T
G
II
GG
T
LT
A
T
LLAIF
FV
P
LF
F
V
LV
fig|550677.3.peg.2753
Escherichia coli B354 (17-1023/1035)
AI
L
I
M
L
A
G
ILA
I
RT
LPV
A
QYP
D
V
AP
P
T
I
K
I
S
A
T
Y
T
GA
S
A
E
T
L
E
N
S
VT
Q
VIE
QQ
L
TG
L
D
N
L
L
Y
F
SS
T
S
SSD
G
SVS
I
N
V
T
FE
Q
GT
D
PD
T
A
QV
QVQ
NK
I
Q
Q
A
ESR
LP
SEVQQT
GV
TVE-KSQSN
---
F
L
LIA
A
VY
D
TTDKASSS
DI
A
D
W
L
VSN
V
QDP
L
A
RVE
GVG
S
L
QVF
G
AEY-AM
RI
W
LDP
AK
L
A
SYS
L
MPSD
V
QS
AI
EAQ
N
VQVTA
G
K
I
G
A
L
P
SPNTQQLTAT
V
R
A
QSR
LQT
V
D
Q
F
KN
I
I
V
KSQS
DG
AV
V
R
I
K
DVA
R
VE
M
G
S
E
DYTAI
G
KL
NG
H
-
P
S
A
G
VA
V
M
L
SP
GAN
ALN
T
ATL
V
KDK
I
AE
F
QRN
M
P
Q
G
YD
IAYP
K
D
S
T
EF
I
KI
S
V
E
D
VIQT
L
F
EAI
V
LV
V
C
V
M
YLFL
Q
N
L
RATLIP
A
L
AVPV
V
L
L
GTF
G
VL
A
L
F
G
Y
S
I
N
T
LT
L
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
R
D
----------
E
GLP
A
RE
A
TE
K
SMG
E
I
S
G
AL
VAIALV
L
S
AVF
L
PM
A
F
FG
G
ST
G
V
IYR
Q
FSIT
IIS
AM
LL
SV
V
VAL
T
LTP
A
LC
G
SV
L
QHVPPH----KKGFFGAF
N
RF
Y
RRTEDK
----
Y
QRGVI
Y
VL
RRAART
M
G
L
Y
V
V
LGGGMAL
M
MWKL
P
GS
FLP
TE
D
Q
G
EIMVQY
T
L
P
A
G
A
T
AARTAEVNR
Q
IV
D
WF
LINEKAN
T
D
V
I
F
TVD
G
FSFSGSGQ
N
TGMAF
---
V
S
LK
N
WS
Q
-
R
KGAENTAQ
AI
A
L
RA
TKELGTIRDAT
V
F--
A
M
-
TPPA
V
DGL
G
QS
N
GFTFE
L
LANGGTDR
E
T
L
LQMRN
QL
IEK
A
NQS
P
-E
L
HS
V
RA
N
D
L
P
QMPQLQ
V
D
I
D
SN
KA
V
S
L
G
L
SL
N
D
V
TDT
L
S
S
A
W
G
GTY
V
NDFIDRGRV
K
K
V
Y
I
Q
GDSEF
R
SA
P
SD
L
GKWF
V
R
G
SD
N
AMT
P
F
S
AF
A
TTRWLY
G
P
ER
L
VRY
N
GS
A
AYE
I
QG
E
N
ATGF
S
S
G
D
A
MTKMEELANS
L
-
-
P
A
G
TTWA
W
S
G
--
LS
L
Q
EK
L
ASGQALS
L
Y
A
-
V
S
I
L
V
VFL
C
L
AA
LYES
WSV
P
FS
V
I
L
V
I
P
L
G
L
L
G
A
A
LA
AWMR
D
LN
NDV
YFQV
A
L
L
TT
IGL
S
S
KNAILIV
E
FA
-EAA
V
AE
----------
G
YSLS
R
A
ALR
A
AQT
R
L
RPI
I
MT
S
LA
F
I
A
G
V
M
PL
AI
A
T
GAG
A
N
SRIA
I
G
T
G
II
GG
T
LT
A
T
LLAIF
FV
P
LF
F
V
LV
fig|199310.4.peg.1640
Escherichia coli CFT073 (17-1023/1035)
AI
L
I
M
L
A
G
ILA
I
RT
LPV
A
QYP
D
V
AP
P
T
I
K
I
S
A
T
Y
T
GA
S
A
E
T
L
E
N
S
VT
Q
VIE
QQ
L
TG
L
D
N
L
L
Y
F
SS
T
S
SSD
G
SVS
I
N
V
T
FE
Q
GT
D
PD
T
A
QV
QVQ
NK
I
Q
Q
A
ESR
LP
SEVQQT
GV
TVE-KSQSN
---
F
L
LIA
A
VY
D
TTDKASSS
DI
A
D
W
L
VSN
V
QDP
L
A
RVE
GVG
S
L
QVF
G
AEY-AM
RI
W
LDP
AK
L
A
SYS
L
MPSD
V
QS
AI
EAQ
N
VQVTA
G
K
I
G
A
L
P
SPNTQQLTAT
V
R
A
QSR
LQT
V
D
Q
F
KN
I
I
V
KSQS
DG
AV
V
R
I
K
DVA
R
VE
M
G
S
E
DYTAI
G
KL
NG
H
-
P
S
A
G
VA
V
M
L
SP
GAN
ALN
T
ATL
V
KDK
I
AE
F
QRN
M
P
Q
G
YD
IAYP
K
D
S
T
EF
I
KI
S
V
E
D
VIQT
L
F
EAI
V
LV
V
C
V
M
YLFL
Q
N
L
RATLIP
A
L
AVPV
V
L
L
GTF
G
VL
A
L
F
G
Y
S
I
N
T
LT
L
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
R
D
----------
E
GLP
A
RE
A
TE
K
SMG
E
I
S
G
AL
VAIALV
L
S
AVF
L
PM
A
F
FG
G
ST
G
V
IYR
Q
FSIT
IIS
AM
LL
SV
V
VAL
T
LTP
A
LC
G
SV
L
QHVPPH----KKGFFGAF
N
RF
Y
RRTEDK
----
Y
QRGVI
Y
VL
RRAART
M
G
L
Y
V
V
LGGGMAL
M
MWKL
P
GS
FLP
TE
D
Q
G
EIMVQY
T
L
P
A
G
A
T
AARTAEVNR
Q
IV
D
WF
LINEKAN
T
D
V
I
F
TVD
G
FSFSGSGQ
N
TGMAF
---
V
S
LK
N
WS
Q
-
R
KGAENTAQ
AI
A
L
RA
TKELGTIRDAT
V
F--
A
M
-
TPPA
V
DGL
G
QS
N
GFTFE
L
LANGGTDR
E
T
L
LQMRN
QL
IEK
A
NQS
P
-E
L
HS
V
RA
N
D
L
P
QMPQLQ
V
D
I
D
SN
KA
V
S
L
G
L
SL
N
D
V
TDT
L
S
S
A
W
G
GTY
V
NDFIDRGRV
K
K
V
Y
I
Q
GDSEF
R
SA
P
SD
L
GKWF
V
R
G
SD
N
AMT
P
F
S
AF
A
TTRWLY
G
P
ER
L
VRY
N
GS
A
AYE
I
QG
E
N
ATGF
S
S
G
D
A
MTKMEELANS
L
-
-
P
A
G
TTWA
W
S
G
--
LS
L
Q
EK
L
ASGQALS
L
Y
A
-
V
S
I
L
V
VFL
C
L
AA
LYES
WSV
P
FS
V
I
L
V
I
P
L
G
L
L
G
A
A
LA
AWMR
D
LN
NDV
YFQV
A
L
L
TT
IGL
S
S
KNAILIV
E
FA
-EAA
V
AE
----------
G
YSLS
R
A
ALR
A
AQT
R
L
RPI
I
MT
S
LA
F
I
A
G
V
M
PL
AI
A
T
GAG
A
N
SRIA
I
G
T
G
II
GG
T
LT
A
T
LLAIF
FV
P
LF
F
V
LV
fig|340197.3.peg.1121
Escherichia coli F11 (17-1023/1035)
AI
L
I
M
L
A
G
ILA
I
RT
LPV
A
QYP
D
V
AP
P
T
I
K
I
S
A
T
Y
T
GA
S
A
E
T
L
E
N
S
VT
Q
VIE
QQ
L
TG
L
D
N
L
L
Y
F
SS
T
S
SSD
G
SVS
I
N
V
T
FE
Q
GT
D
PD
T
A
QV
QVQ
NK
I
Q
Q
A
ESR
LP
SEVQQT
GV
TVE-KSQSN
---
F
L
LIA
A
VY
D
TTDKASSS
DI
A
D
W
L
VSN
V
QDP
L
A
RVE
GVG
S
L
QVF
G
AEY-AM
RI
W
LDP
AK
L
A
SYS
L
MPSD
V
QS
AI
EAQ
N
VQVTA
G
K
I
G
A
L
P
SPNTQQLTAT
V
R
A
QSR
LQT
V
D
Q
F
KN
I
I
V
KSQS
DG
AV
V
R
I
K
DVA
R
VE
M
G
S
E
DYTAI
G
KL
NG
H
-
P
S
A
G
VA
V
M
L
SP
GAN
ALN
T
ATL
V
KDK
I
AE
F
QRN
M
P
Q
G
YD
IAYP
K
D
S
T
EF
I
KI
S
V
E
D
VIQT
L
F
EAI
V
LV
V
C
V
M
YLFL
Q
N
L
RATLIP
A
L
AVPV
V
L
L
GTF
G
VL
A
L
F
G
Y
S
I
N
T
LT
L
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
R
D
----------
E
GLP
A
RE
A
TE
K
SMG
E
I
S
G
AL
VAIALV
L
S
AVF
L
PM
A
F
FG
G
ST
G
V
IYR
Q
FSIT
IIS
AM
LL
SV
V
VAL
T
LTP
A
LC
G
SV
L
QHVPPH----KKGFFGAF
N
RF
Y
RRTEDK
----
Y
QRGVI
Y
VL
RRAART
M
G
L
Y
V
V
LGGGMAL
M
MWKL
P
GS
FLP
TE
D
Q
G
EIMVQY
T
L
P
A
G
A
T
AARTAEVNR
Q
IV
D
WF
LINEKAN
T
D
V
I
F
TVD
G
FSFSGSGQ
N
TGMAF
---
V
S
LK
N
WS
Q
-
R
KGAENTAQ
AI
A
L
RA
TKELGTIRDAT
V
F--
A
M
-
TPPA
V
DGL
G
QS
N
GFTFE
L
LANGGTDR
E
T
L
LQMRN
QL
IEK
A
NQS
P
-E
L
HS
V
RA
N
D
L
P
QMPQLQ
V
D
I
D
SN
KA
V
S
L
G
L
SL
N
D
V
TDT
L
S
S
A
W
G
GTY
V
NDFIDRGRV
K
K
V
Y
I
Q
GDSEF
R
SA
P
SD
L
GKWF
V
R
G
SD
N
AMT
P
F
S
AF
A
TTRWLY
G
P
ER
L
VRY
N
GS
A
AYE
I
QG
E
N
ATGF
S
S
G
D
A
MTKMEELANS
L
-
-
P
A
G
TTWA
W
S
G
--
LS
L
Q
EK
L
ASGQALS
L
Y
A
-
V
S
I
L
V
VFL
C
L
AA
LYES
WSV
P
FS
V
I
L
V
I
P
L
G
L
L
G
A
A
LA
AWMR
D
LN
NDV
YFQV
A
L
L
TT
IGL
S
S
KNAILIV
E
FA
-EAA
V
AE
----------
G
YSLS
R
A
ALR
A
AQT
R
L
RPI
I
MT
S
LA
F
I
A
G
V
M
PL
AI
A
T
GAG
A
N
SRIA
I
G
T
G
II
GG
T
LT
A
T
LLAIF
FV
P
LF
F
V
LV
fig|340197.5.peg.1182
Escherichia coli F11 (17-1023/1035)
AI
L
I
M
L
A
G
ILA
I
RT
LPV
A
QYP
D
V
AP
P
T
I
K
I
S
A
T
Y
T
GA
S
A
E
T
L
E
N
S
VT
Q
VIE
QQ
L
TG
L
D
N
L
L
Y
F
SS
T
S
SSD
G
SVS
I
N
V
T
FE
Q
GT
D
PD
T
A
QV
QVQ
NK
I
Q
Q
A
ESR
LP
SEVQQT
GV
TVE-KSQSN
---
F
L
LIA
A
VY
D
TTDKASSS
DI
A
D
W
L
VSN
V
QDP
L
A
RVE
GVG
S
L
QVF
G
AEY-AM
RI
W
LDP
AK
L
A
SYS
L
MPSD
V
QS
AI
EAQ
N
VQVTA
G
K
I
G
A
L
P
SPNTQQLTAT
V
R
A
QSR
LQT
V
D
Q
F
KN
I
I
V
KSQS
DG
AV
V
R
I
K
DVA
R
VE
M
G
S
E
DYTAI
G
KL
NG
H
-
P
S
A
G
VA
V
M
L
SP
GAN
ALN
T
ATL
V
KDK
I
AE
F
QRN
M
P
Q
G
YD
IAYP
K
D
S
T
EF
I
KI
S
V
E
D
VIQT
L
F
EAI
V
LV
V
C
V
M
YLFL
Q
N
L
RATLIP
A
L
AVPV
V
L
L
GTF
G
VL
A
L
F
G
Y
S
I
N
T
LT
L
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
R
D
----------
E
GLP
A
RE
A
TE
K
SMG
E
I
S
G
AL
VAIALV
L
S
AVF
L
PM
A
F
FG
G
ST
G
V
IYR
Q
FSIT
IIS
AM
LL
SV
V
VAL
T
LTP
A
LC
G
SV
L
QHVPPH----KKGFFGAF
N
RF
Y
RRTEDK
----
Y
QRGVI
Y
VL
RRAART
M
G
L
Y
V
V
LGGGMAL
M
MWKL
P
GS
FLP
TE
D
Q
G
EIMVQY
T
L
P
A
G
A
T
AARTAEVNR
Q
IV
D
WF
LINEKAN
T
D
V
I
F
TVD
G
FSFSGSGQ
N
TGMAF
---
V
S
LK
N
WS
Q
-
R
KGAENTAQ
AI
A
L
RA
TKELGTIRDAT
V
F--
A
M
-
TPPA
V
DGL
G
QS
N
GFTFE
L
LANGGTDR
E
T
L
LQMRN
QL
IEK
A
NQS
P
-E
L
HS
V
RA
N
D
L
P
QMPQLQ
V
D
I
D
SN
KA
V
S
L
G
L
SL
N
D
V
TDT
L
S
S
A
W
G
GTY
V
NDFIDRGRV
K
K
V
Y
I
Q
GDSEF
R
SA
P
SD
L
GKWF
V
R
G
SD
N
AMT
P
F
S
AF
A
TTRWLY
G
P
ER
L
VRY
N
GS
A
AYE
I
QG
E
N
ATGF
S
S
G
D
A
MTKMEELANS
L
-
-
P
A
G
TTWA
W
S
G
--
LS
L
Q
EK
L
ASGQALS
L
Y
A
-
V
S
I
L
V
VFL
C
L
AA
LYES
WSV
P
FS
V
I
L
V
I
P
L
G
L
L
G
A
A
LA
AWMR
D
LN
NDV
YFQV
A
L
L
TT
IGL
S
S
KNAILIV
E
FA
-EAA
V
AE
----------
G
YSLS
R
A
ALR
A
AQT
R
L
RPI
I
MT
S
LA
F
I
A
G
V
M
PL
AI
A
T
GAG
A
N
SRIA
I
G
T
G
II
GG
T
LT
A
T
LLAIF
FV
P
LF
F
V
LV
fig|656393.3.peg.2062
Escherichia coli H299 (17-1023/1035)
AI
L
I
M
L
A
G
ILA
I
RT
LPV
A
QYP
D
V
AP
P
T
I
K
I
S
A
T
Y
T
GA
S
A
E
T
L
E
N
S
VT
Q
VIE
QQ
L
TG
L
D
N
L
L
Y
F
SS
T
S
SSD
G
SVS
I
N
V
T
FE
Q
GT
D
PD
T
A
QV
QVQ
NK
I
Q
Q
A
ESR
LP
SEVQQT
GV
TVE-KSQSN
---
F
L
LIA
A
VY
D
TTDKASSS
DI
A
D
W
L
VSN
V
QDP
L
A
RVE
GVG
S
L
QVF
G
AEY-AM
RI
W
LDP
AK
L
A
SYS
L
MPSD
V
QS
AI
EAQ
N
VQVTA
G
K
I
G
A
L
P
SPNTQQLTAT
V
R
A
QSR
LQT
V
D
Q
F
KN
I
I
V
KSQS
DG
AV
V
R
I
K
DVA
R
VE
M
G
S
E
DYTAI
G
KL
NG
H
-
P
S
A
G
VA
V
M
L
SP
GAN
ALN
T
ATL
V
KDK
I
AE
F
QRN
M
P
Q
G
YD
IAYP
K
D
S
T
EF
I
KI
S
V
E
D
VIQT
L
F
EAI
V
LV
V
C
V
M
YLFL
Q
N
L
RATLIP
A
L
AVPV
V
L
L
GTF
G
VL
A
L
F
G
Y
S
I
N
T
LT
L
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
R
D
----------
E
GLP
A
RE
A
TE
K
SMG
E
I
S
G
AL
VAIALV
L
S
AVF
L
PM
A
F
FG
G
ST
G
V
IYR
Q
FSIT
IIS
AM
LL
SV
V
VAL
T
LTP
A
LC
G
SV
L
QHVPPH----KKGFFGAF
N
RF
Y
RRTEDK
----
Y
QRGVI
Y
VL
RRAART
M
G
L
Y
V
V
LGGGMAL
M
MWKL
P
GS
FLP
TE
D
Q
G
EIMVQY
T
L
P
A
G
A
T
AARTAEVNR
Q
IV
D
WF
LINEKAN
T
D
V
I
F
TVD
G
FSFSGSGQ
N
TGMAF
---
V
S
LK
N
WS
Q
-
R
KGAENTAQ
AI
A
L
RA
TKELGTIRDAT
V
F--
A
M
-
TPPA
V
DGL
G
QS
N
GFTFE
L
LANGGTDR
E
T
L
LQMRN
QL
IEK
A
NQS
P
-E
L
HS
V
RA
N
D
L
P
QMPQLQ
V
D
I
D
SN
KA
V
S
L
G
L
SL
N
D
V
TDT
L
S
S
A
W
G
GTY
V
NDFIDRGRV
K
K
V
Y
I
Q
GDSEF
R
SA
P
SD
L
GKWF
V
R
G
SD
N
AMT
P
F
S
AF
A
TTRWLY
G
P
ER
L
VRY
N
GS
A
AYE
I
QG
E
N
ATGF
S
S
G
D
A
MTKMEELANS
L
-
-
P
A
G
TTWA
W
S
G
--
LS
L
Q
EK
L
ASGQALS
L
Y
A
-
V
S
I
L
V
VFL
C
L
AA
LYES
WSV
P
FS
V
I
L
V
I
P
L
G
L
L
G
A
A
LA
AWMR
D
LN
NDV
YFQV
A
L
L
TT
IGL
S
S
KNAILIV
E
FA
-EAA
V
AE
----------
G
YSLS
R
A
ALR
A
AQT
R
L
RPI
I
MT
S
LA
F
I
A
G
V
M
PL
AI
A
T
GAG
A
N
SRIA
I
G
T
G
II
GG
T
LT
A
T
LLAIF
FV
P
LF
F
V
LV
fig|749546.3.peg.265
Escherichia coli MS 185-1 (17-1023/1035)
AI
L
I
M
L
A
G
ILA
I
RT
LPV
A
QYP
D
V
AP
P
T
I
K
I
S
A
T
Y
T
GA
S
A
E
T
L
E
N
S
VT
Q
VIE
QQ
L
TG
L
D
N
L
L
Y
F
SS
T
S
SSD
G
SVS
I
N
V
T
FE
Q
GT
D
PD
T
A
QV
QVQ
NK
I
Q
Q
A
ESR
LP
SEVQQT
GV
TVE-KSQSN
---
F
L
LIA
A
VY
D
TTDKASSS
DI
A
D
W
L
VSN
V
QDP
L
A
RVE
GVG
S
L
QVF
G
AEY-AM
RI
W
LDP
AK
L
A
SYS
L
MPSD
V
QS
AI
EAQ
N
VQVTA
G
K
I
G
A
L
P
SPNTQQLTAT
V
R
A
QSR
LQT
V
D
Q
F
KN
I
I
V
KSQS
DG
AV
V
R
I
K
DVA
R
VE
M
G
S
E
DYTAI
G
KL
NG
H
-
P
S
A
G
VA
V
M
L
SP
GAN
ALN
T
ATL
V
KDK
I
AE
F
QRN
M
P
Q
G
YD
IAYP
K
D
S
T
EF
I
KI
S
V
E
D
VIQT
L
F
EAI
V
LV
V
C
V
M
YLFL
Q
N
L
RATLIP
A
L
AVPV
V
L
L
GTF
G
VL
A
L
F
G
Y
S
I
N
T
LT
L
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
R
D
----------
E
GLP
A
RE
A
TE
K
SMG
E
I
S
G
AL
VAIALV
L
S
AVF
L
PM
A
F
FG
G
ST
G
V
IYR
Q
FSIT
IIS
AM
LL
SV
V
VAL
T
LTP
A
LC
G
SV
L
QHVPPH----KKGFFGAF
N
RF
Y
RRTEDK
----
Y
QRGVI
Y
VL
RRAART
M
G
L
Y
V
V
LGGGMAL
M
MWKL
P
GS
FLP
TE
D
Q
G
EIMVQY
T
L
P
A
G
A
T
AARTAEVNR
Q
IV
D
WF
LINEKAN
T
D
V
I
F
TVD
G
FSFSGSGQ
N
TGMAF
---
V
S
LK
N
WS
Q
-
R
KGAENTAQ
AI
A
L
RA
TKELGTIRDAT
V
F--
A
M
-
TPPA
V
DGL
G
QS
N
GFTFE
L
LANGGTDR
E
T
L
LQMRN
QL
IEK
A
NQS
P
-E
L
HS
V
RA
N
D
L
P
QMPQLQ
V
D
I
D
SN
KA
V
S
L
G
L
SL
N
D
V
TDT
L
S
S
A
W
G
GTY
V
NDFIDRGRV
K
K
V
Y
I
Q
GDSEF
R
SA
P
SD
L
GKWF
V
R
G
SD
N
AMT
P
F
S
AF
A
TTRWLY
G
P
ER
L
VRY
N
GS
A
AYE
I
QG
E
N
ATGF
S
S
G
D
A
MTKMEELANS
L
-
-
P
A
G
TTWA
W
S
G
--
LS
L
Q
EK
L
ASGQALS
L
Y
A
-
V
S
I
L
V
VFL
C
L
AA
LYES
WSV
P
FS
V
I
L
V
I
P
L
G
L
L
G
A
A
LA
AWMR
D
LN
NDV
YFQV
A
L
L
TT
IGL
S
S
KNAILIV
E
FA
-EAA
V
AE
----------
G
YSLS
R
A
ALR
A
AQT
R
L
RPI
I
MT
S
LA
F
I
A
G
V
M
PL
AI
A
T
GAG
A
N
SRIA
I
G
T
G
II
GG
T
LT
A
T
LLAIF
FV
P
LF
F
V
LV
fig|749550.3.peg.61
Escherichia coli MS 200-1 (17-1023/1035)
AI
L
I
M
L
A
G
ILA
I
RT
LPV
A
QYP
D
V
AP
P
T
I
K
I
S
A
T
Y
T
GA
S
A
E
T
L
E
N
S
VT
Q
VIE
QQ
L
TG
L
D
N
L
L
Y
F
SS
T
S
SSD
G
SVS
I
N
V
T
FE
Q
GT
D
PD
T
A
QV
QVQ
NK
I
Q
Q
A
ESR
LP
SEVQQT
GV
TVE-KSQSN
---
F
L
LIA
A
VY
D
TTDKASSS
DI
A
D
W
L
VSN
V
QDP
L
A
RVE
GVG
S
L
QVF
G
AEY-AM
RI
W
LDP
AK
L
A
SYS
L
MPSD
V
QS
AI
EAQ
N
VQVTA
G
K
I
G
A
L
P
SPNTQQLTAT
V
R
A
QSR
LQT
V
D
Q
F
KN
I
I
V
KSQS
DG
AV
V
R
I
K
DVA
R
VE
M
G
S
E
DYTAI
G
KL
NG
H
-
P
S
A
G
VA
V
M
L
SP
GAN
ALN
T
ATL
V
KDK
I
AE
F
QRN
M
P
Q
G
YD
IAYP
K
D
S
T
EF
I
KI
S
V
E
D
VIQT
L
F
EAI
V
LV
V
C
V
M
YLFL
Q
N
L
RATLIP
A
L
AVPV
V
L
L
GTF
G
VL
A
L
F
G
Y
S
I
N
T
LT
L
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
R
D
----------
E
GLP
A
RE
A
TE
K
SMG
E
I
S
G
AL
VAIALV
L
S
AVF
L
PM
A
F
FG
G
ST
G
V
IYR
Q
FSIT
IIS
AM
LL
SV
V
VAL
T
LTP
A
LC
G
SV
L
QHVPPH----KKGFFGAF
N
RF
Y
RRTEDK
----
Y
QRGVI
Y
VL
RRAART
M
G
L
Y
V
V
LGGGMAL
M
MWKL
P
GS
FLP
TE
D
Q
G
EIMVQY
T
L
P
A
G
A
T
AARTAEVNR
Q
IV
D
WF
LINEKAN
T
D
V
I
F
TVD
G
FSFSGSGQ
N
TGMAF
---
V
S
LK
N
WS
Q
-
R
KGAENTAQ
AI
A
L
RA
TKELGTIRDAT
V
F--
A
M
-
TPPA
V
DGL
G
QS
N
GFTFE
L
LANGGTDR
E
T
L
LQMRN
QL
IEK
A
NQS
P
-E
L
HS
V
RA
N
D
L
P
QMPQLQ
V
D
I
D
SN
KA
V
S
L
G
L
SL
N
D
V
TDT
L
S
S
A
W
G
GTY
V
NDFIDRGRV
K
K
V
Y
I
Q
GDSEF
R
SA
P
SD
L
GKWF
V
R
G
SD
N
AMT
P
F
S
AF
A
TTRWLY
G
P
ER
L
VRY
N
GS
A
AYE
I
QG
E
N
ATGF
S
S
G
D
A
MTKMEELANS
L
-
-
P
A
G
TTWA
W
S
G
--
LS
L
Q
EK
L
ASGQALS
L
Y
A
-
V
S
I
L
V
VFL
C
L
AA
LYES
WSV
P
FS
V
I
L
V
I
P
L
G
L
L
G
A
A
LA
AWMR
D
LN
NDV
YFQV
A
L
L
TT
IGL
S
S
KNAILIV
E
FA
-EAA
V
AE
----------
G
YSLS
R
A
ALR
A
AQT
R
L
RPI
I
MT
S
LA
F
I
A
G
V
M
PL
AI
A
T
GAG
A
N
SRIA
I
G
T
G
II
GG
T
LT
A
T
LLAIF
FV
P
LF
F
V
LV
fig|749528.3.peg.176
Escherichia coli MS 45-1 (17-1023/1035)
AI
L
I
M
L
A
G
ILA
I
RT
LPV
A
QYP
D
V
AP
P
T
I
K
I
S
A
T
Y
T
GA
S
A
E
T
L
E
N
S
VT
Q
VIE
QQ
L
TG
L
D
N
L
L
Y
F
SS
T
S
SSD
G
SVS
I
N
V
T
FE
Q
GT
D
PD
T
A
QV
QVQ
NK
I
Q
Q
A
ESR
LP
SEVQQT
GV
TVE-KSQSN
---
F
L
LIA
A
VY
D
TTDKASSS
DI
A
D
W
L
VSN
V
QDP
L
A
RVE
GVG
S
L
QVF
G
AEY-AM
RI
W
LDP
AK
L
A
SYS
L
MPSD
V
QS
AI
EAQ
N
VQVTA
G
K
I
G
A
L
P
SPNTQQLTAT
V
R
A
QSR
LQT
V
D
Q
F
KN
I
I
V
KSQS
DG
AV
V
R
I
K
DVA
R
VE
M
G
S
E
DYTAI
G
KL
NG
H
-
P
S
A
G
VA
V
M
L
SP
GAN
ALN
T
ATL
V
KDK
I
AE
F
QRN
M
P
Q
G
YD
IAYP
K
D
S
T
EF
I
KI
S
V
E
D
VIQT
L
F
EAI
V
LV
V
C
V
M
YLFL
Q
N
L
RATLIP
A
L
AVPV
V
L
L
GTF
G
VL
A
L
F
G
Y
S
I
N
T
LT
L
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
R
D
----------
E
GLP
A
RE
A
TE
K
SMG
E
I
S
G
AL
VAIALV
L
S
AVF
L
PM
A
F
FG
G
ST
G
V
IYR
Q
FSIT
IIS
AM
LL
SV
V
VAL
T
LTP
A
LC
G
SV
L
QHVPPH----KKGFFGAF
N
RF
Y
RRTEDK
----
Y
QRGVI
Y
VL
RRAART
M
G
L
Y
V
V
LGGGMAL
M
MWKL
P
GS
FLP
TE
D
Q
G
EIMVQY
T
L
P
A
G
A
T
AARTAEVNR
Q
IV
D
WF
LINEKAN
T
D
V
I
F
TVD
G
FSFSGSGQ
N
TGMAF
---
V
S
LK
N
WS
Q
-
R
KGAENTAQ
AI
A
L
RA
TKELGTIRDAT
V
F--
A
M
-
TPPA
V
DGL
G
QS
N
GFTFE
L
LANGGTDR
E
T
L
LQMRN
QL
IEK
A
NQS
P
-E
L
HS
V
RA
N
D
L
P
QMPQLQ
V
D
I
D
SN
KA
V
S
L
G
L
SL
N
D
V
TDT
L
S
S
A
W
G
GTY
V
NDFIDRGRV
K
K
V
Y
I
Q
GDSEF
R
SA
P
SD
L
GKWF
V
R
G
SD
N
AMT
P
F
S
AF
A
TTRWLY
G
P
ER
L
VRY
N
GS
A
AYE
I
QG
E
N
ATGF
S
S
G
D
A
MTKMEELANS
L
-
-
P
A
G
TTWA
W
S
G
--
LS
L
Q
EK
L
ASGQALS
L
Y
A
-
V
S
I
L
V
VFL
C
L
AA
LYES
WSV
P
FS
V
I
L
V
I
P
L
G
L
L
G
A
A
LA
AWMR
D
LN
NDV
YFQV
A
L
L
TT
IGL
S
S
KNAILIV
E
FA
-EAA
V
AE
----------
G
YSLS
R
A
ALR
A
AQT
R
L
RPI
I
MT
S
LA
F
I
A
G
V
M
PL
AI
A
T
GAG
A
N
SRIA
I
G
T
G
II
GG
T
LT
A
T
LLAIF
FV
P
LF
F
V
LV
fig|685038.3.peg.1335
Escherichia coli O83:H1 str. NRG 857C (17-1023/1035)
AI
L
I
M
L
A
G
ILA
I
RT
LPV
A
QYP
D
V
AP
P
T
I
K
I
S
A
T
Y
T
GA
S
A
E
T
L
E
N
S
VT
Q
VIE
QQ
L
TG
L
D
N
L
L
Y
F
SS
T
S
SSD
G
SVS
I
N
V
T
FE
Q
GT
D
PD
T
A
QV
QVQ
NK
I
Q
Q
A
ESR
LP
SEVQQT
GV
TVE-KSQSN
---
F
L
LIA
A
VY
D
TTDKASSS
DI
A
D
W
L
VSN
V
QDP
L
A
RVE
GVG
S
L
QVF
G
AEY-AM
RI
W
LDP
AK
L
A
SYS
L
MPSD
V
QS
AI
EAQ
N
VQVTA
G
K
I
G
A
L
P
SPNTQQLTAT
V
R
A
QSR
LQT
V
D
Q
F
KN
I
I
V
KSQS
DG
AV
V
R
I
K
DVA
R
VE
M
G
S
E
DYTAI
G
KL
NG
H
-
P
S
A
G
VA
V
M
L
SP
GAN
ALN
T
ATL
V
KDK
I
AE
F
QRN
M
P
Q
G
YD
IAYP
K
D
S
T
EF
I
KI
S
V
E
D
VIQT
L
F
EAI
V
LV
V
C
V
M
YLFL
Q
N
L
RATLIP
A
L
AVPV
V
L
L
GTF
G
VL
A
L
F
G
Y
S
I
N
T
LT
L
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
R
D
----------
E
GLP
A
RE
A
TE
K
SMG
E
I
S
G
AL
VAIALV
L
S
AVF
L
PM
A
F
FG
G
ST
G
V
IYR
Q
FSIT
IIS
AM
LL
SV
V
VAL
T
LTP
A
LC
G
SV
L
QHVPPH----KKGFFGAF
N
RF
Y
RRTEDK
----
Y
QRGVI
Y
VL
RRAART
M
G
L
Y
V
V
LGGGMAL
M
MWKL
P
GS
FLP
TE
D
Q
G
EIMVQY
T
L
P
A
G
A
T
AARTAEVNR
Q
IV
D
WF
LINEKAN
T
D
V
I
F
TVD
G
FSFSGSGQ
N
TGMAF
---
V
S
LK
N
WS
Q
-
R
KGAENTAQ
AI
A
L
RA
TKELGTIRDAT
V
F--
A
M
-
TPPA
V
DGL
G
QS
N
GFTFE
L
LANGGTDR
E
T
L
LQMRN
QL
IEK
A
NQS
P
-E
L
HS
V
RA
N
D
L
P
QMPQLQ
V
D
I
D
SN
KA
V
S
L
G
L
SL
N
D
V
TDT
L
S
S
A
W
G
GTY
V
NDFIDRGRV
K
K
V
Y
I
Q
GDSEF
R
SA
P
SD
L
GKWF
V
R
G
SD
N
AMT
P
F
S
AF
A
TTRWLY
G
P
ER
L
VRY
N
GS
A
AYE
I
QG
E
N
ATGF
S
S
G
D
A
MTKMEELANS
L
-
-
P
A
G
TTWA
W
S
G
--
LS
L
Q
EK
L
ASGQALS
L
Y
A
-
V
S
I
L
V
VFL
C
L
AA
LYES
WSV
P
FS
V
I
L
V
I
P
L
G
L
L
G
A
A
LA
AWMR
D
LN
NDV
YFQV
A
L
L
TT
IGL
S
S
KNAILIV
E
FA
-EAA
V
AE
----------
G
YSLS
R
A
ALR
A
AQT
R
L
RPI
I
MT
S
LA
F
I
A
G
V
M
PL
AI
A
T
GAG
A
N
SRIA
I
G
T
G
II
GG
T
LT
A
T
LLAIF
FV
P
LF
F
V
LV
fig|439855.10.peg.1994
Escherichia coli SMS-3-5 (17-1023/1035)
AI
L
I
M
L
A
G
ILA
I
RT
LPV
A
QYP
D
V
AP
P
T
I
K
I
S
A
T
Y
T
GA
S
A
E
T
L
E
N
S
VT
Q
VIE
QQ
L
TG
L
D
N
L
L
Y
F
SS
T
S
SSD
G
SVS
I
N
V
T
FE
Q
GT
D
PD
T
A
QV
QVQ
NK
I
Q
Q
A
ESR
LP
SEVQQT
GV
TVE-KSQSN
---
F
L
LIA
A
VY
D
TTDKASSS
DI
A
D
W
L
VSN
V
QDP
L
A
RVE
GVG
S
L
QVF
G
AEY-AM
RI
W
LDP
AK
L
A
SYS
L
MPSD
V
QS
AI
EAQ
N
VQVTA
G
K
I
G
A
L
P
SPNTQQLTAT
V
R
A
QSR
LQT
V
D
Q
F
KN
I
I
V
KSQS
DG
AV
V
R
I
K
DVA
R
VE
M
G
S
E
DYTAI
G
KL
NG
H
-
P
S
A
G
VA
V
M
L
SP
GAN
ALN
T
ATL
V
KDK
I
AE
F
QRN
M
P
Q
G
YD
IAYP
K
D
S
T
EF
I
KI
S
V
E
D
VIQT
L
F
EAI
V
LV
V
C
V
M
YLFL
Q
N
L
RATLIP
A
L
AVPV
V
L
L
GTF
G
VL
A
L
F
G
Y
S
I
N
T
LT
L
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
R
D
----------
E
GLP
A
RE
A
TE
K
SMG
E
I
S
G
AL
VAIALV
L
S
AVF
L
PM
A
F
FG
G
ST
G
V
IYR
Q
FSIT
IIS
AM
LL
SV
V
VAL
T
LTP
A
LC
G
SV
L
QHVPPH----KKGFFGAF
N
RF
Y
RRTEDK
----
Y
QRGVI
Y
VL
RRAART
M
G
L
Y
V
V
LGGGMAL
M
MWKL
P
GS
FLP
TE
D
Q
G
EIMVQY
T
L
P
A
G
A
T
AARTAEVNR
Q
IV
D
WF
LINEKAN
T
D
V
I
F
TVD
G
FSFSGSGQ
N
TGMAF
---
V
S
LK
N
WS
Q
-
R
KGAENTAQ
AI
A
L
RA
TKELGTIRDAT
V
F--
A
M
-
TPPA
V
DGL
G
QS
N
GFTFE
L
LANGGTDR
E
T
L
LQMRN
QL
IEK
A
NQS
P
-E
L
HS
V
RA
N
D
L
P
QMPQLQ
V
D
I
D
SN
KA
V
S
L
G
L
SL
N
D
V
TDT
L
S
S
A
W
G
GTY
V
NDFIDRGRV
K
K
V
Y
I
Q
GDSEF
R
SA
P
SD
L
GKWF
V
R
G
SD
N
AMT
P
F
S
AF
A
TTRWLY
G
P
ER
L
VRY
N
GS
A
AYE
I
QG
E
N
ATGF
S
S
G
D
A
MTKMEELANS
L
-
-
P
A
G
TTWA
W
S
G
--
LS
L
Q
EK
L
ASGQALS
L
Y
A
-
V
S
I
L
V
VFL
C
L
AA
LYES
WSV
P
FS
V
I
L
V
I
P
L
G
L
L
G
A
A
LA
AWMR
D
LN
NDV
YFQV
A
L
L
TT
IGL
S
S
KNAILIV
E
FA
-EAA
V
AE
----------
G
YSLS
R
A
ALR
A
AQT
R
L
RPI
I
MT
S
LA
F
I
A
G
V
M
PL
AI
A
T
GAG
A
N
SRIA
I
G
T
G
II
GG
T
LT
A
T
LLAIF
FV
P
LF
F
V
LV
fig|562.376.peg.3163
Escherichia coli WV_060327 (17-1023/1035)
AI
L
I
M
L
A
G
ILA
I
RT
LPV
A
QYP
D
V
AP
P
T
I
K
I
S
A
T
Y
T
GA
S
A
E
T
L
E
N
S
VT
Q
VIE
QQ
L
TG
L
D
N
L
L
Y
F
SS
T
S
SSD
G
SVS
I
N
V
T
FE
Q
GT
D
PD
T
A
QV
QVQ
NK
I
Q
Q
A
ESR
LP
SEVQQT
GV
TVE-KSQSN
---
F
L
LIA
A
VY
D
TTDKASSS
DI
A
D
W
L
VSN
V
QDP
L
A
RVE
GVG
S
L
QVF
G
AEY-AM
RI
W
LDP
AK
L
A
SYS
L
MPSD
V
QS
AI
EAQ
N
VQVTA
G
K
I
G
A
L
P
SPNTQQLTAT
V
R
A
QSR
LQT
V
D
Q
F
KN
I
I
V
KSQS
DG
AV
V
R
I
K
DVA
R
VE
M
G
S
E
DYTAI
G
KL
NG
H
-
P
S
A
G
VA
V
M
L
SP
GAN
ALN
T
ATL
V
KDK
I
AE
F
QRN
M
P
Q
G
YD
IAYP
K
D
S
T
EF
I
KI
S
V
E
D
VIQT
L
F
EAI
V
LV
V
C
V
M
YLFL
Q
N
L
RATLIP
A
L
AVPV
V
L
L
GTF
G
VL
A
L
F
G
Y
S
I
N
T
LT
L
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
R
D
----------
E
GLP
A
RE
A
TE
K
SMG
E
I
S
G
AL
VAIALV
L
S
AVF
L
PM
A
F
FG
G
ST
G
V
IYR
Q
FSIT
IIS
AM
LL
SV
V
VAL
T
LTP
A
LC
G
SV
L
QHVPPH----KKGFFGAF
N
RF
Y
RRTEDK
----
Y
QRGVI
Y
VL
RRAART
M
G
L
Y
V
V
LGGGMAL
M
MWKL
P
GS
FLP
TE
D
Q
G
EIMVQY
T
L
P
A
G
A
T
AARTAEVNR
Q
IV
D
WF
LINEKAN
T
D
V
I
F
TVD
G
FSFSGSGQ
N
TGMAF
---
V
S
LK
N
WS
Q
-
R
KGAENTAQ
AI
A
L
RA
TKELGTIRDAT
V
F--
A
M
-
TPPA
V
DGL
G
QS
N
GFTFE
L
LANGGTDR
E
T
L
LQMRN
QL
IEK
A
NQS
P
-E
L
HS
V
RA
N
D
L
P
QMPQLQ
V
D
I
D
SN
KA
V
S
L
G
L
SL
N
D
V
TDT
L
S
S
A
W
G
GTY
V
NDFIDRGRV
K
K
V
Y
I
Q
GDSEF
R
SA
P
SD
L
GKWF
V
R
G
SD
N
AMT
P
F
S
AF
A
TTRWLY
G
P
ER
L
VRY
N
GS
A
AYE
I
QG
E
N
ATGF
S
S
G
D
A
MTKMEELANS
L
-
-
P
A
G
TTWA
W
S
G
--
LS
L
Q
EK
L
ASGQALS
L
Y
A
-
V
S
I
L
V
VFL
C
L
AA
LYES
WSV
P
FS
V
I
L
V
I
P
L
G
L
L
G
A
A
LA
AWMR
D
LN
NDV
YFQV
A
L
L
TT
IGL
S
S
KNAILIV
E
FA
-EAA
V
AE
----------
G
YSLS
R
A
ALR
A
AQT
R
L
RPI
I
MT
S
LA
F
I
A
G
V
M
PL
AI
A
T
GAG
A
N
SRIA
I
G
T
G
II
GG
T
LT
A
T
LLAIF
FV
P
LF
F
V
LV
fig|714962.3.peg.1532
Escherichia coli IHE3034 (17-1023/1035)
AI
L
I
M
L
A
G
ILA
I
RT
LPV
A
QYP
D
V
AP
P
T
I
K
I
S
A
T
Y
T
GA
S
A
E
T
L
E
N
S
VT
Q
VIE
QQ
L
TG
L
D
N
L
L
Y
F
SS
T
S
SSD
G
SVS
I
N
V
T
FE
Q
GT
D
PD
T
A
QV
QVQ
NK
I
Q
Q
A
ESR
LP
SEVQQT
GV
TVE-KSQSN
---
F
L
LIA
A
VY
D
TTDKASSS
DI
A
D
W
L
VSN
V
QDP
L
A
RVE
GVG
S
L
QVF
G
AEY-AM
RI
W
LDP
AK
L
A
SYS
L
MPSD
V
QS
AI
EAQ
N
VQVTA
G
K
I
G
A
L
P
SPNTQQLTAT
V
R
A
QSR
LQT
V
D
Q
F
KN
I
I
V
KSQS
DG
AV
V
R
I
K
DVA
R
VE
M
G
S
E
DYTAI
G
KL
NG
H
-
P
S
A
G
VA
V
M
L
SP
GAN
ALN
T
ATL
V
KDK
I
AE
F
QRN
M
P
Q
G
YD
IAYP
K
D
S
T
EF
I
KI
S
V
E
D
VIQT
L
F
EAI
V
LV
V
C
V
M
YLFL
Q
N
L
RATLIP
A
L
AVPV
V
L
L
GTF
G
VL
A
L
F
G
Y
S
I
N
T
LT
L
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
R
D
----------
E
GLP
A
RE
A
TE
K
SMG
E
I
S
G
AL
VAIALV
L
S
AVF
L
PM
A
F
FG
G
ST
G
V
IYR
Q
FSIT
IIS
AM
LL
SV
V
VAL
T
LTP
A
LC
G
SV
L
QHVPPH----KKGFFGAF
N
RF
Y
RRTEDK
----
Y
QRGVI
Y
VL
RRAART
M
G
L
Y
V
V
LGGGMAL
M
MWKL
P
GS
FLP
TE
D
Q
G
EIMVQY
T
L
P
A
G
A
T
AARTAEVNR
Q
IV
D
WF
LINEKAN
T
D
V
I
F
TVD
G
FSFSGSGQ
N
TGMAF
---
V
S
LK
N
WS
Q
-
R
KGAENTAQ
AI
A
L
RA
TKELGTIRDAT
V
F--
A
M
-
TPPA
V
DGL
G
QS
N
GFTFE
L
LANGGADR
E
T
L
LQMRN
QL
IEK
A
NQS
P
-E
L
HS
V
RA
N
D
L
P
QMPQLQ
V
D
I
D
SN
KA
V
S
L
G
L
SL
N
D
V
TDT
L
S
S
A
W
G
GTY
V
NDFIDRGRV
K
K
V
Y
I
Q
GDSEF
R
SA
P
SD
L
GKWF
V
R
G
SD
N
AMT
P
F
S
AF
A
TTRWLY
G
P
ER
L
VRY
N
GS
A
AYE
I
QG
E
N
ATGF
S
S
G
D
A
MTKMEELANS
L
-
-
P
A
G
TTWA
W
S
G
--
LS
L
Q
EK
L
ASGQALS
L
Y
A
-
V
S
I
L
V
VFL
C
L
AA
LYES
WSV
P
FS
V
I
L
V
I
P
L
G
L
L
G
A
A
LA
AWMR
D
LN
NDV
YFQV
A
L
L
TT
IGL
S
S
KNAILIV
E
FA
-EAA
V
AE
----------
G
YSLS
R
A
ALR
A
AQT
R
L
RPI
I
MT
S
LA
F
I
A
G
V
M
PL
AI
A
T
GAG
A
N
SRIA
I
G
T
G
II
GG
T
LT
A
T
LLAIF
FV
P
LF
F
V
LV
fig|585035.6.peg.1423
Escherichia coli S88 (17-1023/1035)
AI
L
I
M
L
A
G
ILA
I
RT
LPV
A
QYP
D
V
AP
P
T
I
K
I
S
A
T
Y
T
GA
S
A
E
T
L
E
N
S
VT
Q
VIE
QQ
L
TG
L
D
N
L
L
Y
F
SS
T
S
SSD
G
SVS
I
N
V
T
FE
Q
GT
D
PD
T
A
QV
QVQ
NK
I
Q
Q
A
ESR
LP
SEVQQT
GV
TVE-KSQSN
---
F
L
LIA
A
VY
D
TTDKASSS
DI
A
D
W
L
VSN
V
QDP
L
A
RVE
GVG
S
L
QVF
G
AEY-AM
RI
W
LDP
AK
L
A
SYS
L
MPSD
V
QS
AI
EAQ
N
VQVTA
G
K
I
G
A
L
P
SPNTQQLTAT
V
R
A
QSR
LQT
V
D
Q
F
KN
I
I
V
KSQS
DG
AV
V
R
I
K
DVA
R
VE
M
G
S
E
DYTAI
G
KL
NG
H
-
P
S
A
G
VA
V
M
L
SP
GAN
ALN
T
ATL
V
KDK
I
AE
F
QRN
M
P
Q
G
YD
IAYP
K
D
S
T
EF
I
KI
S
V
E
D
VIQT
L
F
EAI
V
LV
V
C
V
M
YLFL
Q
N
L
RATLIP
A
L
AVPV
V
L
L
GTF
G
VL
A
L
F
G
Y
S
I
N
T
LT
L
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
R
D
----------
E
GLP
A
RE
A
TE
K
SMG
E
I
S
G
AL
VAIALV
L
S
AVF
L
PM
A
F
FG
G
ST
G
V
IYR
Q
FSIT
IIS
AM
LL
SV
V
VAL
T
LTP
A
LC
G
SV
L
QHVPPH----KKGFFGAF
N
RF
Y
RRTEDK
----
Y
QRGVI
Y
VL
RRAART
M
G
L
Y
V
V
LGGGMAL
M
MWKL
P
GS
FLP
TE
D
Q
G
EIMVQY
T
L
P
A
G
A
T
AARTAEVNR
Q
IV
D
WF
LINEKAN
T
D
V
I
F
TVD
G
FSFSGSGQ
N
TGMAF
---
V
S
LK
N
WS
Q
-
R
KGAENTAQ
AI
A
L
RA
TKELGTIRDAT
V
F--
A
M
-
TPPA
V
DGL
G
QS
N
GFTFE
L
LANGGADR
E
T
L
LQMRN
QL
IEK
A
NQS
P
-E
L
HS
V
RA
N
D
L
P
QMPQLQ
V
D
I
D
SN
KA
V
S
L
G
L
SL
N
D
V
TDT
L
S
S
A
W
G
GTY
V
NDFIDRGRV
K
K
V
Y
I
Q
GDSEF
R
SA
P
SD
L
GKWF
V
R
G
SD
N
AMT
P
F
S
AF
A
TTRWLY
G
P
ER
L
VRY
N
GS
A
AYE
I
QG
E
N
ATGF
S
S
G
D
A
MTKMEELANS
L
-
-
P
A
G
TTWA
W
S
G
--
LS
L
Q
EK
L
ASGQALS
L
Y
A
-
V
S
I
L
V
VFL
C
L
AA
LYES
WSV
P
FS
V
I
L
V
I
P
L
G
L
L
G
A
A
LA
AWMR
D
LN
NDV
YFQV
A
L
L
TT
IGL
S
S
KNAILIV
E
FA
-EAA
V
AE
----------
G
YSLS
R
A
ALR
A
AQT
R
L
RPI
I
MT
S
LA
F
I
A
G
V
M
PL
AI
A
T
GAG
A
N
SRIA
I
G
T
G
II
GG
T
LT
A
T
LLAIF
FV
P
LF
F
V
LV
fig|364106.7.peg.1603
Escherichia coli UTI89 (17-1023/1035)
AI
L
I
M
L
A
G
ILA
I
RT
LPV
A
QYP
D
V
AP
P
T
I
K
I
S
A
T
Y
T
GA
S
A
E
T
L
E
N
S
VT
Q
VIE
QQ
L
TG
L
D
N
L
L
Y
F
SS
T
S
SSD
G
SVS
I
N
V
T
FE
Q
GT
D
PD
T
A
QV
QVQ
NK
I
Q
Q
A
ESR
LP
SEVQQT
GV
TVE-KSQSN
---
F
L
LIA
A
VY
D
TTDKASSS
DI
A
D
W
L
VSN
V
QDP
L
A
RVE
GVG
S
L
QVF
G
AEY-AM
RI
W
LDP
AK
L
A
SYS
L
MPSD
V
QS
AI
EAQ
N
VQVTA
G
K
I
G
A
L
P
SPNTQQLTAT
V
R
A
QSR
LQT
V
D
Q
F
KN
I
I
V
KSQS
DG
AV
V
R
I
K
DVA
R
VE
M
G
S
E
DYTAI
G
KL
NG
H
-
P
S
A
G
VA
V
M
L
SP
GAN
ALN
T
ATL
V
KDK
I
AE
F
QRN
M
P
Q
G
YD
IAYP
K
D
S
T
EF
I
KI
S
V
E
D
VIQT
L
F
EAI
V
LV
V
C
V
M
YLFL
Q
N
L
RATLIP
A
L
AVPV
V
L
L
GTF
G
VL
A
L
F
G
Y
S
I
N
T
LT
L
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
R
D
----------
E
GLP
A
RE
A
TE
K
SMG
E
I
S
G
AL
VAIALV
L
S
AVF
L
PM
A
F
FG
G
ST
G
V
IYR
Q
FSIT
IIS
AM
LL
SV
V
VAL
T
LTP
A
LC
G
SV
L
QHVPPH----KKGFFGAF
N
RF
Y
RRTEDK
----
Y
QRGVI
Y
VL
RRAART
M
G
L
Y
V
V
LGGGMAL
M
MWKL
P
GS
FLP
TE
D
Q
G
EIMVQY
T
L
P
A
G
A
T
AARTAEVNR
Q
IV
D
WF
LINEKAN
T
D
V
I
F
TVD
G
FSFSGSGQ
N
TGMAF
---
V
S
LK
N
WS
Q
-
R
KGAENTAQ
AI
A
L
RA
TKELGTIRDAT
V
F--
A
M
-
TPPA
V
DGL
G
QS
N
GFTFE
L
LANGGADR
E
T
L
LQMRN
QL
IEK
A
NQS
P
-E
L
HS
V
RA
N
D
L
P
QMPQLQ
V
D
I
D
SN
KA
V
S
L
G
L
SL
N
D
V
TDT
L
S
S
A
W
G
GTY
V
NDFIDRGRV
K
K
V
Y
I
Q
GDSEF
R
SA
P
SD
L
GKWF
V
R
G
SD
N
AMT
P
F
S
AF
A
TTRWLY
G
P
ER
L
VRY
N
GS
A
AYE
I
QG
E
N
ATGF
S
S
G
D
A
MTKMEELANS
L
-
-
P
A
G
TTWA
W
S
G
--
LS
L
Q
EK
L
ASGQALS
L
Y
A
-
V
S
I
L
V
VFL
C
L
AA
LYES
WSV
P
FS
V
I
L
V
I
P
L
G
L
L
G
A
A
LA
AWMR
D
LN
NDV
YFQV
A
L
L
TT
IGL
S
S
KNAILIV
E
FA
-EAA
V
AE
----------
G
YSLS
R
A
ALR
A
AQT
R
L
RPI
I
MT
S
LA
F
I
A
G
V
M
PL
AI
A
T
GAG
A
N
SRIA
I
G
T
G
II
GG
T
LT
A
T
LLAIF
FV
P
LF
F
V
LV
fig|364106.8.peg.1603
Escherichia coli UTI89 (17-1023/1035)
AI
L
I
M
L
A
G
ILA
I
RT
LPV
A
QYP
D
V
AP
P
T
I
K
I
S
A
T
Y
T
GA
S
A
E
T
L
E
N
S
VT
Q
VIE
QQ
L
TG
L
D
N
L
L
Y
F
SS
T
S
SSD
G
SVS
I
N
V
T
FE
Q
GT
D
PD
T
A
QV
QVQ
NK
I
Q
Q
A
ESR
LP
SEVQQT
GV
TVE-KSQSN
---
F
L
LIA
A
VY
D
TTDKASSS
DI
A
D
W
L
VSN
V
QDP
L
A
RVE
GVG
S
L
QVF
G
AEY-AM
RI
W
LDP
AK
L
A
SYS
L
MPSD
V
QS
AI
EAQ
N
VQVTA
G
K
I
G
A
L
P
SPNTQQLTAT
V
R
A
QSR
LQT
V
D
Q
F
KN
I
I
V
KSQS
DG
AV
V
R
I
K
DVA
R
VE
M
G
S
E
DYTAI
G
KL
NG
H
-
P
S
A
G
VA
V
M
L
SP
GAN
ALN
T
ATL
V
KDK
I
AE
F
QRN
M
P
Q
G
YD
IAYP
K
D
S
T
EF
I
KI
S
V
E
D
VIQT
L
F
EAI
V
LV
V
C
V
M
YLFL
Q
N
L
RATLIP
A
L
AVPV
V
L
L
GTF
G
VL
A
L
F
G
Y
S
I
N
T
LT
L
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
R
D
----------
E
GLP
A
RE
A
TE
K
SMG
E
I
S
G
AL
VAIALV
L
S
AVF
L
PM
A
F
FG
G
ST
G
V
IYR
Q
FSIT
IIS
AM
LL
SV
V
VAL
T
LTP
A
LC
G
SV
L
QHVPPH----KKGFFGAF
N
RF
Y
RRTEDK
----
Y
QRGVI
Y
VL
RRAART
M
G
L
Y
V
V
LGGGMAL
M
MWKL
P
GS
FLP
TE
D
Q
G
EIMVQY
T
L
P
A
G
A
T
AARTAEVNR
Q
IV
D
WF
LINEKAN
T
D
V
I
F
TVD
G
FSFSGSGQ
N
TGMAF
---
V
S
LK
N
WS
Q
-
R
KGAENTAQ
AI
A
L
RA
TKELGTIRDAT
V
F--
A
M
-
TPPA
V
DGL
G
QS
N
GFTFE
L
LANGGADR
E
T
L
LQMRN
QL
IEK
A
NQS
P
-E
L
HS
V
RA
N
D
L
P
QMPQLQ
V
D
I
D
SN
KA
V
S
L
G
L
SL
N
D
V
TDT
L
S
S
A
W
G
GTY
V
NDFIDRGRV
K
K
V
Y
I
Q
GDSEF
R
SA
P
SD
L
GKWF
V
R
G
SD
N
AMT
P
F
S
AF
A
TTRWLY
G
P
ER
L
VRY
N
GS
A
AYE
I
QG
E
N
ATGF
S
S
G
D
A
MTKMEELANS
L
-
-
P
A
G
TTWA
W
S
G
--
LS
L
Q
EK
L
ASGQALS
L
Y
A
-
V
S
I
L
V
VFL
C
L
AA
LYES
WSV
P
FS
V
I
L
V
I
P
L
G
L
L
G
A
A
LA
AWMR
D
LN
NDV
YFQV
A
L
L
TT
IGL
S
S
KNAILIV
E
FA
-EAA
V
AE
----------
G
YSLS
R
A
ALR
A
AQT
R
L
RPI
I
MT
S
LA
F
I
A
G
V
M
PL
AI
A
T
GAG
A
N
SRIA
I
G
T
G
II
GG
T
LT
A
T
LLAIF
FV
P
LF
F
V
LV
fig|869729.3.peg.2190
Escherichia coli UM146 (17-1017/1022)
AI
L
I
M
L
A
G
ILA
I
RT
LPV
A
QYP
D
V
AP
P
T
I
K
I
S
A
T
Y
T
GA
S
A
E
T
L
E
N
S
VT
Q
VIE
QQ
L
TG
L
D
N
L
L
Y
F
SS
T
S
SSD
G
SVS
I
N
V
T
FE
Q
GT
D
PD
T
A
QV
QVQ
NK
I
Q
Q
A
ESR
LP
SEVQQT
GV
TVE-KSQSN
---
F
L
LIA
A
VY
D
TTDKASSS
DI
A
D
W
L
VSN
V
QDP
L
A
RVE
GVG
S
L
QVF
G
AEY-AM
RI
W
LDP
AK
L
A
SYS
L
MPSD
V
QS
AI
EAQ
N
VQVTA
G
K
I
G
A
L
P
SPNTQQLTAT
V
R
A
QSR
LQT
V
D
Q
F
KN
I
I
V
KSQS
DG
AV
V
R
I
K
DVA
R
VE
M
G
S
E
DYTAI
G
KL
NG
H
-
P
S
A
G
VA
V
M
L
SP
GAN
ALN
T
ATL
V
KDK
I
AE
F
QRN
M
P
Q
G
YD
IAYP
K
D
S
T
EF
I
KI
S
V
E
D
VIQT
L
F
EAI
V
LV
V
C
V
M
YLFL
Q
N
L
RATLIP
A
L
AVPV
V
L
L
GTF
G
VL
A
L
F
G
Y
S
I
N
T
LT
L
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
R
D
----------
E
GLP
A
RE
A
TE
K
SMG
E
I
S
G
AL
VAIALV
L
S
AVF
L
PM
A
F
FG
G
ST
G
V
IYR
Q
FSIT
IIS
AM
LL
SV
V
VAL
T
LTP
A
LC
G
SV
L
QHVPPH----KKGFFGAF
N
RF
Y
RRTEDK
----
Y
QRGVI
Y
VL
RRAART
M
G
L
Y
V
V
LGGGMAL
M
MWKL
P
GS
FLP
TE
D
Q
G
EIMVQY
T
L
P
A
G
A
T
AARTAEVNR
Q
IV
D
WF
LINEKAN
T
D
V
I
F
TVD
G
FSFSGSGQ
N
TGMAF
---
V
S
LK
N
WS
Q
-
R
KGAENTAQ
AI
A
L
RA
TKELGTIRDAT
V
F--
A
M
-
TPPA
V
DGL
G
QS
N
GFTFE
L
LANGGADR
E
T
L
LQMRN
QL
IEK
A
NQS
P
-E
L
HS
V
RA
N
D
L
P
QMPQLQ
V
D
I
D
SN
KA
V
S
L
G
L
SL
N
D
V
TDT
L
S
S
A
W
G
GTY
V
NDFIDRGRV
K
K
V
Y
I
Q
GDSEF
R
SA
P
SD
L
GKWF
V
R
G
SD
N
AMT
P
F
S
AF
A
TTRWLY
G
P
ER
L
VRY
N
GS
A
AYE
I
QG
E
N
ATGF
S
S
G
D
A
MTKMEELANS
L
-
-
P
A
G
TTWA
W
S
G
--
LS
L
Q
EK
L
ASGQALS
L
Y
A
-
V
S
I
L
V
VFL
C
L
AA
LYES
WSV
P
FS
V
I
L
V
I
P
L
G
L
L
G
A
A
LA
AWMR
D
LN
NDV
YFQV
A
L
L
TT
IGL
S
S
KNAILIV
E
FA
-EAA
V
AE
----------
G
YSLS
R
A
ALR
A
AQT
R
L
RPI
I
MT
S
LA
F
I
A
G
V
M
PL
AI
A
T
GAG
A
N
SRIA
I
G
T
G
II
GG
T
LT
A
T
LLAIF
FV
P
fig|405955.13.peg.1406
Escherichia coli APEC O1 (17-1023/1035)
AI
L
I
M
L
A
G
ILA
I
RT
LPV
A
QYP
D
V
AP
P
T
I
K
V
S
A
T
Y
T
GA
S
A
E
T
L
E
N
S
VT
Q
VIE
QQ
L
TG
L
D
N
L
L
Y
F
SS
T
S
SSD
G
SVS
I
N
V
T
FE
Q
GT
D
PD
T
A
QV
QVQ
NK
I
Q
Q
A
ESR
LP
SEVQQT
GV
TVE-KSQSN
---
F
L
LIA
A
VY
D
TTDKASSS
DI
A
D
W
L
VSN
V
QDP
L
A
RVE
GVG
S
L
QVF
G
AEY-AM
RI
W
LDP
AK
L
A
SYS
L
MPSD
V
QS
AI
EAQ
N
VQVTA
G
K
I
G
A
L
P
SPNTQQLTAT
V
R
A
QSR
LQT
V
D
Q
F
KN
I
I
V
KSQS
DG
AV
V
R
I
K
DVA
R
VE
M
G
S
E
DYTAI
G
KL
NG
H
-
P
S
A
G
VA
V
M
L
SP
GAN
ALN
T
ATL
V
KDK
I
AE
F
QRN
M
P
Q
G
YD
IAYP
K
D
S
T
EF
I
KI
S
V
E
D
VIQT
L
F
EAI
V
LV
V
C
V
M
YLFL
Q
N
L
RATLIP
A
L
AVPV
V
L
L
GTF
G
VL
A
L
F
G
Y
S
I
N
T
LT
L
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
R
D
----------
E
GLP
A
RE
A
TE
K
SMG
E
I
S
G
AL
VAIALV
L
S
AVF
L
PM
A
F
FG
G
ST
G
V
IYR
Q
FSIT
IIS
AM
LL
SV
V
VAL
T
LTP
A
LC
G
SV
L
QHVPPH----KKGFFGAF
N
RF
Y
RRTEDK
----
Y
QRGVI
Y
VL
RRAART
M
G
L
Y
V
V
LGGGMAL
M
MWKL
P
GS
FLP
TE
D
Q
G
EIMVQY
T
L
P
A
G
A
T
AARTAEVNR
Q
IV
D
WF
LINEKAN
T
D
V
I
F
TVD
G
FSFSGSGQ
N
TGMAF
---
V
S
LK
N
WS
Q
-
R
KGAENTAQ
AI
A
L
RA
TKELGTIRDAT
V
F--
A
M
-
TPPA
V
DGL
G
QS
N
GFTFE
L
LANGGADR
E
T
L
LQMRN
QL
IEK
A
NQS
P
-E
L
HS
V
RA
N
D
L
P
QMPQLQ
V
D
I
D
SN
KA
V
S
L
G
L
SL
N
D
V
TDT
L
S
S
A
W
G
GTY
V
NDFIDRGRV
K
K
V
Y
I
Q
GDSEF
R
SA
P
SD
L
GKWF
V
R
G
SD
N
AMT
P
F
S
AF
A
TTRWLY
G
P
ER
L
VRY
N
GS
A
AYE
I
QG
E
N
ATGF
S
S
G
D
A
MTKMEELANS
L
-
-
P
A
G
TTWA
W
S
G
--
LS
L
Q
EK
L
ASGQALS
L
Y
A
-
V
S
I
L
V
VFL
C
L
AA
LYES
WSV
P
FS
V
I
L
V
I
P
L
G
L
L
G
A
A
LA
AWMR
D
LN
NDV
YFQV
A
L
L
TT
IGL
S
S
KNAILIV
E
FA
-EAA
V
AE
----------
G
YSLS
R
A
ALR
A
AQT
R
L
RPI
I
MT
S
LA
F
I
A
G
V
M
PL
AI
A
T
GAG
A
N
SRIA
I
G
T
G
II
GG
T
LT
A
T
LLAIF
FV
P
LF
F
V
LV
fig|405955.9.peg.1156
Escherichia coli APEC O1 (17-1023/1035)
AI
L
I
M
L
A
G
ILA
I
RT
LPV
A
QYP
D
V
AP
P
T
I
K
V
S
A
T
Y
T
GA
S
A
E
T
L
E
N
S
VT
Q
VIE
QQ
L
TG
L
D
N
L
L
Y
F
SS
T
S
SSD
G
SVS
I
N
V
T
FE
Q
GT
D
PD
T
A
QV
QVQ
NK
I
Q
Q
A
ESR
LP
SEVQQT
GV
TVE-KSQSN
---
F
L
LIA
A
VY
D
TTDKASSS
DI
A
D
W
L
VSN
V
QDP
L
A
RVE
GVG
S
L
QVF
G
AEY-AM
RI
W
LDP
AK
L
A
SYS
L
MPSD
V
QS
AI
EAQ
N
VQVTA
G
K
I
G
A
L
P
SPNTQQLTAT
V
R
A
QSR
LQT
V
D
Q
F
KN
I
I
V
KSQS
DG
AV
V
R
I
K
DVA
R
VE
M
G
S
E
DYTAI
G
KL
NG
H
-
P
S
A
G
VA
V
M
L
SP
GAN
ALN
T
ATL
V
KDK
I
AE
F
QRN
M
P
Q
G
YD
IAYP
K
D
S
T
EF
I
KI
S
V
E
D
VIQT
L
F
EAI
V
LV
V
C
V
M
YLFL
Q
N
L
RATLIP
A
L
AVPV
V
L
L
GTF
G
VL
A
L
F
G
Y
S
I
N
T
LT
L
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
R
D
----------
E
GLP
A
RE
A
TE
K
SMG
E
I
S
G
AL
VAIALV
L
S
AVF
L
PM
A
F
FG
G
ST
G
V
IYR
Q
FSIT
IIS
AM
LL
SV
V
VAL
T
LTP
A
LC
G
SV
L
QHVPPH----KKGFFGAF
N
RF
Y
RRTEDK
----
Y
QRGVI
Y
VL
RRAART
M
G
L
Y
V
V
LGGGMAL
M
MWKL
P
GS
FLP
TE
D
Q
G
EIMVQY
T
L
P
A
G
A
T
AARTAEVNR
Q
IV
D
WF
LINEKAN
T
D
V
I
F
TVD
G
FSFSGSGQ
N
TGMAF
---
V
S
LK
N
WS
Q
-
R
KGAENTAQ
AI
A
L
RA
TKELGTIRDAT
V
F--
A
M
-
TPPA
V
DGL
G
QS
N
GFTFE
L
LANGGADR
E
T
L
LQMRN
QL
IEK
A
NQS
P
-E
L
HS
V
RA
N
D
L
P
QMPQLQ
V
D
I
D
SN
KA
V
S
L
G
L
SL
N
D
V
TDT
L
S
S
A
W
G
GTY
V
NDFIDRGRV
K
K
V
Y
I
Q
GDSEF
R
SA
P
SD
L
GKWF
V
R
G
SD
N
AMT
P
F
S
AF
A
TTRWLY
G
P
ER
L
VRY
N
GS
A
AYE
I
QG
E
N
ATGF
S
S
G
D
A
MTKMEELANS
L
-
-
P
A
G
TTWA
W
S
G
--
LS
L
Q
EK
L
ASGQALS
L
Y
A
-
V
S
I
L
V
VFL
C
L
AA
LYES
WSV
P
FS
V
I
L
V
I
P
L
G
L
L
G
A
A
LA
AWMR
D
LN
NDV
YFQV
A
L
L
TT
IGL
S
S
KNAILIV
E
FA
-EAA
V
AE
----------
G
YSLS
R
A
ALR
A
AQT
R
L
RPI
I
MT
S
LA
F
I
A
G
V
M
PL
AI
A
T
GAG
A
N
SRIA
I
G
T
G
II
GG
T
LT
A
T
LLAIF
FV
P
LF
F
V
LV
fig|656417.3.peg.1603
Escherichia coli M605 (17-1023/1035)
AI
L
I
M
L
A
G
ILA
I
RT
LPV
A
QYP
D
V
AP
P
T
I
K
I
S
A
T
Y
T
GA
S
A
E
T
L
E
N
S
VT
Q
VIE
QQ
L
TG
L
D
N
L
L
Y
F
SS
T
S
SSD
G
SVS
I
N
V
T
FE
Q
GT
D
PD
T
A
QV
QVQ
NK
I
Q
Q
A
ESR
LP
SEVQQT
GV
TVE-KSQSN
---
F
L
LIA
A
VY
D
TTDKASSS
DI
A
D
W
L
VSN
V
QDP
L
A
RVE
GVG
S
L
QVF
G
AEY-AM
RI
W
LDP
AK
L
A
SSS
L
MPSD
V
QS
AI
EAQ
N
VQVTA
G
K
I
G
A
L
P
SPDTQQLTAT
V
R
A
QSR
LQT
V
D
Q
F
KN
I
I
V
KSQS
DG
AV
V
R
I
K
DVA
R
VE
M
G
S
E
DYTAI
G
KL
NG
H
-
P
S
A
G
VA
V
M
L
SP
GAN
ALN
T
ATL
V
KDK
I
AE
F
QRN
M
P
Q
G
YD
IAYP
K
D
S
T
EF
I
KI
S
V
E
D
VIQT
L
F
EAI
V
LV
V
C
V
M
YLFL
Q
N
L
RATLIP
A
L
AVPV
V
L
L
GTF
G
VL
A
L
F
G
Y
S
I
N
T
LT
L
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
R
D
----------
E
GLP
A
RE
A
TE
K
SMG
E
I
S
G
AL
VAIALV
L
S
AVF
L
PM
A
F
FG
G
ST
G
V
IYR
Q
FSIT
IIS
AM
LL
SV
V
VAL
T
LTP
A
LC
G
SV
L
QHVPPH----KKGFFGAF
N
RF
Y
RRTEDK
----
Y
QRGVI
Y
VL
RRAART
M
G
L
Y
V
V
LGGGMAL
M
MWKL
P
GS
FLP
TE
D
Q
G
EIMVQY
T
L
P
A
G
A
T
AARTAEVNR
Q
IV
D
WF
LINEKAN
T
D
V
I
F
TVD
G
FSFSGSGQ
N
TGMAF
---
V
S
LK
N
WS
Q
-
R
KGAENTAQ
AI
A
L
RA
TKELGTIRDAT
V
F--
A
M
-
TPPA
V
DGL
G
QS
N
GFTFE
L
LANGGTDR
E
T
L
LQMRN
QL
IEK
A
NQS
P
-E
L
HS
V
RA
N
D
L
P
QMPQLQ
V
D
I
D
SN
KA
V
S
L
G
L
SL
N
D
V
TDT
L
S
S
A
W
G
GTY
V
NDFIDRGRV
K
K
V
Y
I
Q
GDSEF
R
SA
P
SD
L
GKWF
V
R
G
SD
N
AMT
P
F
S
AF
A
TTRWLY
G
P
ER
L
VRY
N
GS
A
AYE
I
QG
E
N
ATGF
S
S
G
D
A
MTKMEELANS
L
-
-
P
A
G
TTWA
W
S
G
--
LS
L
Q
EK
L
ASGQALS
L
Y
A
-
V
S
I
L
V
VFL
C
L
AA
LYES
WSV
P
FS
V
I
L
V
I
P
L
G
L
L
G
A
A
LA
AWMR
D
LN
NDV
YFQV
A
L
L
TT
IGL
S
S
KNAILIV
E
FA
-EAA
V
AE
----------
G
YSLS
R
A
ALR
A
AQT
R
L
RPI
I
MT
S
LA
F
I
A
G
V
M
PL
AI
A
T
GAG
A
N
SRIA
I
G
T
G
II
GG
T
LT
A
T
LLAIF
FV
P
LF
F
V
LV
fig|562.373.peg.5239
Escherichia coli 1125A (17-1023/1035)
AI
L
I
M
L
A
G
ILA
I
RT
LPV
A
QYP
D
V
AP
P
T
I
K
I
S
A
T
Y
T
GA
S
A
E
T
L
E
N
S
VT
Q
VIE
QQ
L
TG
L
D
N
L
L
Y
F
SS
T
S
SSD
G
SVS
I
N
V
T
FE
Q
GT
D
PD
T
A
QV
QVQ
NK
I
Q
Q
A
ESR
LP
SEVQQT
GV
TVE-KSQSN
---
F
L
LIA
A
VY
D
TTDKASSS
DI
A
D
W
L
VSN
V
QDP
L
A
RVE
GVG
S
L
QVF
G
AEY-AM
RI
W
LDP
AK
L
A
SYS
L
MPSD
V
QS
AI
EAQ
N
VQVTA
G
K
I
G
A
L
P
SPNTQQLTAT
V
R
A
QSR
LQT
V
D
Q
F
KN
I
I
V
KSQS
D
S
AV
V
R
I
K
DVA
R
VE
M
G
S
E
DYTAI
G
KL
NG
H
-
P
S
A
G
VA
V
M
L
SP
GAN
ALN
T
ATL
V
KDK
I
AE
F
QRN
M
P
Q
G
YD
IAYP
K
D
S
T
EF
I
KI
S
V
E
D
VIQT
L
F
EAI
V
LV
V
C
V
M
YLFL
Q
N
L
RATLIP
A
L
AVPV
V
L
L
GTF
G
VL
A
L
F
G
Y
S
I
N
T
LT
L
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
R
D
----------
K
GLP
A
RE
A
TE
K
SMG
E
I
S
G
AL
VAIVLV
L
S
AVF
L
PM
A
F
FG
G
ST
G
V
IYR
Q
FSIT
IIS
AM
LL
SV
V
VAL
T
LTP
A
LC
G
SV
L
QHVPPH----KKGFFGAF
D
RF
Y
RRTEDK
----
Y
QRGVI
Y
VL
RRAART
M
G
L
Y
L
V
LGGGMAL
M
MWKL
P
GS
FLP
TE
D
Q
G
EIMVQY
T
L
P
A
G
A
T
AARTAEVNR
Q
IV
D
WF
LINEKAN
T
D
V
I
F
TVD
G
FSFSGSGQ
N
TGMAF
---
V
S
LK
N
WS
Q
-
R
KGAENTAQ
AI
A
L
RA
TKELGTIRDAT
V
F--
A
M
-
TPPA
V
DGL
G
QS
N
GFTFE
L
LANGGTDR
E
T
L
LQMRN
QL
IEK
A
NQS
P
-E
L
HS
V
RA
N
D
L
P
QMPQLQ
V
D
I
D
SN
KA
V
S
L
G
L
SL
N
D
V
TDT
L
S
S
A
W
G
GTY
V
NDFIDRGRV
K
K
V
Y
I
Q
GDSEF
R
SA
P
SD
L
GKWF
V
R
G
SD
N
AMT
P
F
S
AF
A
TTRWLY
G
P
ER
L
VRY
N
GS
A
AYE
I
QG
E
N
ATGF
S
S
G
D
A
MTKMEELANS
L
-
-
P
A
G
TTWA
W
S
G
--
LS
L
Q
EK
L
ASGQALS
L
Y
A
-
V
S
I
L
V
VFL
C
L
AA
LYES
WSV
P
FS
V
I
L
V
I
P
L
G
L
L
G
A
A
LA
AWMR
D
LN
NDV
YFQV
A
L
L
TT
IGL
S
S
KNAILIV
E
FA
-EAA
V
AE
----------
G
YSLS
R
A
ALR
A
AQT
R
L
RPI
I
MT
S
LA
F
I
A
G
V
M
PL
AI
A
T
G
S
G
A
N
SRIA
I
G
T
G
II
GG
T
LT
A
T
LLAIF
FV
P
LF
F
V
LV
fig|749548.3.peg.1997
Escherichia coli MS 196-1 (16-1026/1037)
AI
L
L
C
L
T
G
TLA
I
FS
LPV
E
QYP
D
L
AP
P
N
V
R
V
T
A
N
YPGA
S
AQ
T
L
E
N
T
VT
Q
VIE
QN
M
TG
L
D
N
LM
Y
MSS
Q
S
SGT
G
QAS
V
TL
S
F
K
A
GT
D
PD
E
A
VQ
QVQ
NQ
LQ
S
A
MRK
LP
QAVQNQ
GV
TVR-KTGDT
---
N
I
LTI
A
FV
S
TDGSMDKQ
DI
A
D
Y
V
ASN
I
QDP
LS
RVN
GVG
D
I
DAY
G
SQY-SM
RI
W
LDP
AK
LN
SFQ
M
TAKD
V
TD
AI
ESQ
N
AQIAV
GQLGG
T
P
SVDKQALNAT
I
N
A
QSL
LQT
P
E
Q
F
RD
I
T
L
RVNQ
DG
SE
V
R
L
G
DVA
T
VE
M
G
A
E
KYDYL
S
RF
NGK
-
P
A
S
G
LG
V
K
L
AS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQY
FP
H
G
L
E
YKVA
Y
E
TT
SF
V
KA
SI
E
D
VVKT
L
L
EAI
A
LV
F
LV
M
YLFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
S
VL
Y
A
F
G
Y
S
V
N
T
LTM
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
E
GLT
P
RE
A
TR
K
SMG
QIQ
G
AL
VGIAMV
L
S
AVF
V
PM
A
F
FG
G
TT
G
A
IYR
Q
FSIT
IVA
AM
VL
SV
L
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWF
N
QM
F
NRNAER
----
Y
EKGVA
K
I
L
HRSLRW
I
V
I
Y
V
L
LLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKGVE
Q
IE
K
YY
FTHEKDN
I
M
SVF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFNQIKEAR
V
I--
A
S
-
SPPA
I
SGL
G
SS
A
GFDME
L
QDHAGAGH
D
A
L
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
L
D
DSPQLQ
ID
I
D
QR
KA
Q
A
L
GV
AI
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
ML
P
DD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VG
EA
APGV
S
T
G
T
A
MDIMESLVKQ
L
-
-
P
N
G
FGLE
W
T
A
--
MS
YQ
ER
L
SGAQAPA
L
Y
A
-
I
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NEMN
Q
K-
----------
G
HDLF
EA
TLH
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
S
T
GAGSG
GQHA
VG
T
GVMGGM
IS
A
T
I
LAI
Y
FV
P
LF
F
V
LV
fig|216593.1.peg.2195
Escherichia coli E2348/69 (16-1026/1037)
AI
L
L
C
L
T
G
TLA
I
FS
LPV
E
QYP
D
L
AP
P
N
V
R
V
T
A
N
YPGA
S
AQ
T
L
E
N
T
VT
Q
VIE
QN
M
TG
L
D
N
LM
Y
MSS
Q
S
SGT
G
QAS
V
TL
S
F
K
A
GT
D
PD
E
A
VQ
QVQ
NQ
LQ
S
A
MRK
LP
QAVQNQ
GV
TVR-KTGDT
---
N
I
LTI
A
FV
S
TDGSMDKQ
DI
A
D
Y
V
ASN
I
QDP
LS
RVN
GVG
D
I
DAY
G
SQY-SM
RI
W
LDP
AK
LN
SFQ
M
TAKD
V
TD
AI
ESQ
N
AQIAV
GQLGG
T
P
SVDKQALNAT
I
N
A
QSL
LQT
P
E
Q
F
RD
I
T
L
RVNQ
DG
SE
V
R
L
G
DVA
T
VE
M
G
A
E
KYDYL
S
RF
NGK
-
P
A
S
G
LG
V
K
L
AS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQY
FP
H
G
L
E
YKVA
Y
E
TT
SF
V
KA
SI
E
D
VVKT
L
L
EAI
A
LV
F
LV
M
YLFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
S
VL
Y
A
F
G
Y
S
V
N
T
LTM
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
E
GLT
P
RE
A
TR
K
SMG
QIQ
G
AL
VGIAMV
L
S
AVF
V
PM
A
F
FG
G
TT
G
A
IYR
Q
FSIT
IVA
AM
VL
SV
L
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWF
N
QM
F
NRNAER
----
Y
EKGVA
K
I
L
HRSLRW
I
V
I
Y
V
L
LLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IE
K
YY
FTHEKDN
I
M
SVF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFNKIKEAR
V
I--
A
S
-
SPPA
I
SGL
G
SS
A
GFDME
L
QDHAGAGH
D
A
L
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
L
D
DSPQLQ
ID
I
D
QR
KA
Q
A
L
GV
AI
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
ML
P
DD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VG
EA
APGV
S
T
G
T
A
MDIMESLVKQ
L
-
-
P
N
G
FGLE
W
T
A
--
MS
YQ
ER
L
SGAQAPA
L
Y
A
-
I
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NEMN
Q
K-
----------
G
HDLF
EA
TLH
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
S
T
GAGSG
GLHA
VG
T
GVMGGM
IS
A
T
I
LAI
Y
FV
P
LF
F
V
LV
fig|216592.1.peg.5437
Escherichia coli 042 (16-1026/1037)
AI
L
L
C
L
T
G
TLA
I
FS
LPV
E
QYP
D
L
AP
P
N
V
R
V
T
A
N
YPGA
S
AQ
T
L
E
N
T
VT
Q
VIE
QN
M
TG
L
D
N
LM
Y
MSS
Q
S
SGT
G
QAS
V
TL
S
F
K
A
GT
D
PD
E
A
VQ
QVQ
NQ
LQ
S
A
MRK
LP
QAVQNQ
GV
TVR-KTGDT
---
N
I
LTI
A
FV
S
TDGSMDKQ
DI
A
D
Y
V
ASN
I
QDP
LS
RVN
GVG
D
I
DAY
G
SQY-SM
RI
W
LDP
AK
LN
SFQ
M
TAKD
V
TD
AI
ESQ
N
AQIAV
GQLGG
T
P
SVDKQALNAT
I
N
A
QSL
LQT
P
E
Q
F
RD
I
T
L
RVNQ
DG
SE
V
R
L
G
DVA
T
VE
M
G
A
E
KYDYL
S
RF
NGK
-
P
A
S
G
LG
V
K
L
AS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQY
FP
H
G
L
E
YKVA
Y
E
TT
SF
V
KA
SI
E
D
VVKT
L
L
EAI
A
LV
F
LV
M
YLFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
S
I
L
Y
A
F
G
Y
S
V
N
T
LTM
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
E
GLT
P
RE
A
TR
K
SMG
QIQ
G
AL
VGIAMV
L
S
AVF
V
PM
A
F
FG
G
TT
G
A
IYR
Q
FSIT
IVA
AM
VL
SV
L
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWF
N
QM
F
NRNAER
----
Y
EKGVA
K
I
L
HRSLRW
I
V
I
Y
V
L
LLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IE
K
YY
FTHEKDN
I
M
SVF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFNKIKEAR
V
I--
A
S
-
SPPA
I
SGL
G
SS
A
GFDME
L
QDHAGAGH
D
A
L
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
L
D
DSPQLQ
ID
I
D
QR
KA
Q
A
L
GV
AI
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
ML
P
DD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VG
EA
APGV
S
T
G
T
A
MDIMESLVKQ
L
-
-
P
N
G
FGLE
W
T
A
--
MS
YQ
ER
L
SGAQAPA
L
Y
A
-
I
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
S
FA
NEMN
Q
K-
----------
G
HDLF
EA
TLH
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
S
T
GAGSG
GQHA
VG
T
GVMGGM
IS
A
T
I
LAI
Y
FV
P
LF
F
V
LV
fig|216592.3.peg.2793
Escherichia coli 042 (16-1026/1037)
AI
L
L
C
L
T
G
TLA
I
FS
LPV
E
QYP
D
L
AP
P
N
V
R
V
T
A
N
YPGA
S
AQ
T
L
E
N
T
VT
Q
VIE
QN
M
TG
L
D
N
LM
Y
MSS
Q
S
SGT
G
QAS
V
TL
S
F
K
A
GT
D
PD
E
A
VQ
QVQ
NQ
LQ
S
A
MRK
LP
QAVQNQ
GV
TVR-KTGDT
---
N
I
LTI
A
FV
S
TDGSMDKQ
DI
A
D
Y
V
ASN
I
QDP
LS
RVN
GVG
D
I
DAY
G
SQY-SM
RI
W
LDP
AK
LN
SFQ
M
TAKD
V
TD
AI
ESQ
N
AQIAV
GQLGG
T
P
SVDKQALNAT
I
N
A
QSL
LQT
P
E
Q
F
RD
I
T
L
RVNQ
DG
SE
V
R
L
G
DVA
T
VE
M
G
A
E
KYDYL
S
RF
NGK
-
P
A
S
G
LG
V
K
L
AS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQY
FP
H
G
L
E
YKVA
Y
E
TT
SF
V
KA
SI
E
D
VVKT
L
L
EAI
A
LV
F
LV
M
YLFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
S
I
L
Y
A
F
G
Y
S
V
N
T
LTM
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
E
GLT
P
RE
A
TR
K
SMG
QIQ
G
AL
VGIAMV
L
S
AVF
V
PM
A
F
FG
G
TT
G
A
IYR
Q
FSIT
IVA
AM
VL
SV
L
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWF
N
QM
F
NRNAER
----
Y
EKGVA
K
I
L
HRSLRW
I
V
I
Y
V
L
LLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IE
K
YY
FTHEKDN
I
M
SVF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFNKIKEAR
V
I--
A
S
-
SPPA
I
SGL
G
SS
A
GFDME
L
QDHAGAGH
D
A
L
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
L
D
DSPQLQ
ID
I
D
QR
KA
Q
A
L
GV
AI
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
ML
P
DD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VG
EA
APGV
S
T
G
T
A
MDIMESLVKQ
L
-
-
P
N
G
FGLE
W
T
A
--
MS
YQ
ER
L
SGAQAPA
L
Y
A
-
I
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
S
FA
NEMN
Q
K-
----------
G
HDLF
EA
TLH
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
S
T
GAGSG
GQHA
VG
T
GVMGGM
IS
A
T
I
LAI
Y
FV
P
LF
F
V
LV
fig|656379.3.peg.3043
Escherichia coli FVEC1302 (16-1026/1037)
AI
L
L
C
L
T
G
TLA
I
FS
LPV
E
QYP
D
L
AP
P
N
V
R
V
T
A
N
YPGA
S
AQ
T
L
E
N
T
VT
Q
VIE
QN
M
TG
L
D
N
LM
Y
MSS
Q
S
SGT
G
QAS
V
TL
S
F
K
A
GT
D
PD
E
A
VQ
QVQ
NQ
LQ
S
A
MRK
LP
QAVQNQ
GV
TVR-KTGDT
---
N
I
LTI
A
FV
S
TDGSMDKQ
DI
A
D
Y
V
ASN
I
QDP
LS
RVN
GVG
D
I
DAY
G
SQY-SM
RI
W
LDP
AK
LN
SFQ
M
TAKD
V
TD
AI
ESQ
N
AQIAV
GQLGG
T
P
SVDKQALNAT
I
N
A
QSL
LQT
P
E
Q
F
RD
I
T
L
RVNQ
DG
SE
V
R
L
G
DVA
T
VE
M
G
A
E
KYDYL
S
RF
NGK
-
P
A
S
G
LG
V
K
L
AS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQY
FP
H
G
L
E
YKVA
Y
E
TT
SF
V
KA
SI
E
D
VVKT
L
L
EAI
A
LV
F
LV
M
YLFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
S
VL
Y
A
F
G
Y
S
V
N
T
LTM
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
E
GLT
P
RE
A
TR
K
SMG
QIQ
G
AL
VGIAMV
L
S
AVF
V
PM
A
F
FG
G
TT
G
A
IYR
Q
FSIT
IVA
AM
VL
SV
L
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWF
N
QM
F
NRNAER
----
Y
EKGVA
K
I
L
HRSLRW
I
V
I
Y
V
L
LLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IE
K
YY
FTHEKDN
I
M
SVF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFNKIKEAR
V
I--
A
S
-
SPPA
I
SGL
G
SS
A
GFDME
L
QDHAGAGH
E
A
L
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
L
D
DSPQLQ
ID
I
D
QR
KA
Q
A
L
GV
AI
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
ML
P
DD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VG
EA
APGV
S
T
G
T
A
MDIMESLVKQ
L
-
-
P
N
G
FGLE
W
T
A
--
MS
YQ
ER
L
SGAQAPA
L
Y
A
-
I
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NEMN
Q
K-
----------
G
HDLF
EA
TLH
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
S
T
GAGSG
GQHA
VG
T
GVMGGM
IS
A
T
I
LAI
Y
FV
P
LF
F
V
LV
fig|656380.3.peg.2543
Escherichia coli FVEC1412 (16-1026/1037)
AI
L
L
C
L
T
G
TLA
I
FS
LPV
E
QYP
D
L
AP
P
N
V
R
V
T
A
N
YPGA
S
AQ
T
L
E
N
T
VT
Q
VIE
QN
M
TG
L
D
N
LM
Y
MSS
Q
S
SGT
G
QAS
V
TL
S
F
K
A
GT
D
PD
E
A
VQ
QVQ
NQ
LQ
S
A
MRK
LP
QAVQNQ
GV
TVR-KTGDT
---
N
I
LTI
A
FV
S
TDGSMDKQ
DI
A
D
Y
V
ASN
I
QDP
LS
RVN
GVG
D
I
DAY
G
SQY-SM
RI
W
LDP
AK
LN
SFQ
M
TAKD
V
TD
AI
ESQ
N
AQIAV
GQLGG
T
P
SVDKQALNAT
I
N
A
QSL
LQT
P
E
Q
F
RD
I
T
L
RVNQ
DG
SE
V
R
L
G
DVA
T
VE
M
G
A
E
KYDYL
S
RF
NGK
-
P
A
S
G
LG
V
K
L
AS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQY
FP
H
G
L
E
YKVA
Y
E
TT
SF
V
KA
SI
E
D
VVKT
L
L
EAI
A
LV
F
LV
M
YLFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
S
VL
Y
A
F
G
Y
S
V
N
T
LTM
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
E
GLT
P
RE
A
TR
K
SMG
QIQ
G
AL
VGIAMV
L
S
AVF
V
PM
A
F
FG
G
TT
G
A
IYR
Q
FSIT
IVA
AM
VL
SV
L
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWF
N
QM
F
NRNAER
----
Y
EKGVA
K
I
L
HRSLRW
I
V
I
Y
V
L
LLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IE
K
YY
FTHEKDN
I
M
SVF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFNKIKEAR
V
I--
A
S
-
SPPA
I
SGL
G
SS
A
GFDME
L
QDHAGAGH
E
A
L
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
L
D
DSPQLQ
ID
I
D
QR
KA
Q
A
L
GV
AI
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
ML
P
DD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VG
EA
APGV
S
T
G
T
A
MDIMESLVKQ
L
-
-
P
N
G
FGLE
W
T
A
--
MS
YQ
ER
L
SGAQAPA
L
Y
A
-
I
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NEMN
Q
K-
----------
G
HDLF
EA
TLH
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
S
T
GAGSG
GQHA
VG
T
GVMGGM
IS
A
T
I
LAI
Y
FV
P
LF
F
V
LV
fig|749549.3.peg.1756
Escherichia coli MS 198-1 (16-1026/1037)
AI
L
L
C
L
T
G
TLA
I
FS
LPV
E
QYP
D
L
AP
P
N
V
R
V
T
A
N
YPGA
S
AQ
T
L
E
N
T
VT
Q
VIE
QN
M
TG
L
D
N
LM
Y
MSS
Q
S
SGT
G
QAS
V
TL
S
F
K
A
GT
D
PD
E
A
VQ
QVQ
NQ
LQ
S
A
MRK
LP
QAVQNQ
GV
TVR-KTGDT
---
N
I
LTI
A
FV
S
TDGSMDKQ
DI
A
D
Y
V
ASN
I
QDP
LS
RVN
GVG
D
I
DAY
G
SQY-SM
RI
W
LDP
AK
LN
SFQ
M
TAKD
V
TD
AI
ESQ
N
AQIAV
GQLGG
T
P
SVDKQALNAT
I
N
A
QSL
LQT
P
E
Q
F
RD
I
T
L
RVNQ
DG
SE
V
R
L
G
DVA
T
VE
M
G
A
E
KYDYL
S
RF
NGK
-
P
A
S
G
LG
V
K
L
AS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQY
FP
H
G
L
E
YKVA
Y
E
TT
SF
V
KA
SI
E
D
VVKT
L
L
EAI
A
LV
F
LV
M
YLFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
S
VL
Y
A
F
G
Y
S
V
N
T
LTM
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
E
GLT
P
RE
A
TR
K
SMG
QIQ
G
AL
VGIAMV
L
S
AVF
V
PM
A
F
FG
G
TT
G
A
IYR
Q
FSIT
IVA
AM
VL
SV
L
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWF
N
QM
F
NRNAER
----
Y
EKGVA
K
I
L
HRSLRW
I
V
I
Y
V
L
LLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IE
K
YY
FTHEKDN
I
M
SVF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFNKIKEAR
V
I--
A
S
-
SPPA
I
SGL
G
SS
A
GFDME
L
QDHAGAGH
E
A
L
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
L
D
DSPQLQ
ID
I
D
QR
KA
Q
A
L
GV
AI
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
ML
P
DD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VG
EA
APGV
S
T
G
T
A
MDIMESLVKQ
L
-
-
P
N
G
FGLE
W
T
A
--
MS
YQ
ER
L
SGAQAPA
L
Y
A
-
I
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NEMN
Q
K-
----------
G
HDLF
EA
TLH
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
S
T
GAGSG
GQHA
VG
T
GVMGGM
IS
A
T
I
LAI
Y
FV
P
LF
F
V
LV
fig|585056.7.peg.2966
Escherichia coli UMN026 (16-1026/1037)
AI
L
L
C
L
T
G
TLA
I
FS
LPV
E
QYP
D
L
AP
P
N
V
R
V
T
A
N
YPGA
S
AQ
T
L
E
N
T
VT
Q
VIE
QN
M
TG
L
D
N
LM
Y
MSS
Q
S
SGT
G
QAS
V
TL
S
F
K
A
GT
D
PD
E
A
VQ
QVQ
NQ
LQ
S
A
MRK
LP
QAVQNQ
GV
TVR-KTGDT
---
N
I
LTI
A
FV
S
TDGSMDKQ
DI
A
D
Y
V
ASN
I
QDP
LS
RVN
GVG
D
I
DAY
G
SQY-SM
RI
W
LDP
AK
LN
SFQ
M
TAKD
V
TD
AI
ESQ
N
AQIAV
GQLGG
T
P
SVDKQALNAT
I
N
A
QSL
LQT
P
E
Q
F
RD
I
T
L
RVNQ
DG
SE
V
R
L
G
DVA
T
VE
M
G
A
E
KYDYL
S
RF
NGK
-
P
A
S
G
LG
V
K
L
AS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQY
FP
H
G
L
E
YKVA
Y
E
TT
SF
V
KA
SI
E
D
VVKT
L
L
EAI
A
LV
F
LV
M
YLFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
S
VL
Y
A
F
G
Y
S
V
N
T
LTM
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
E
GLT
P
RE
A
TR
K
SMG
QIQ
G
AL
VGIAMV
L
S
AVF
V
PM
A
F
FG
G
TT
G
A
IYR
Q
FSIT
IVA
AM
VL
SV
L
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWF
N
QM
F
NRNAER
----
Y
EKGVA
K
I
L
HRSLRW
I
V
I
Y
V
L
LLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IE
K
YY
FTHEKDN
I
M
SVF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFNKIKEAR
V
I--
A
S
-
SPPA
I
SGL
G
SS
A
GFDME
L
QDHAGAGH
E
A
L
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
L
D
DSPQLQ
ID
I
D
QR
KA
Q
A
L
GV
AI
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
ML
P
DD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VG
EA
APGV
S
T
G
T
A
MDIMESLVKQ
L
-
-
P
N
G
FGLE
W
T
A
--
MS
YQ
ER
L
SGAQAPA
L
Y
A
-
I
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NEMN
Q
K-
----------
G
HDLF
EA
TLH
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
S
T
GAGSG
GQHA
VG
T
GVMGGM
IS
A
T
I
LAI
Y
FV
P
LF
F
V
LV
fig|656393.3.peg.3483
Escherichia coli H299 (16-1026/1037)
AI
L
L
C
L
T
G
TLA
I
FS
LPV
E
QYP
D
L
AP
P
N
V
R
V
T
A
N
YPGA
S
AQ
T
L
E
N
T
VT
Q
VIE
QN
M
TG
L
D
N
LM
Y
MSS
Q
S
SGT
G
QAS
V
TL
S
F
K
A
GT
D
PD
E
A
VQ
QVQ
NQ
LQ
S
A
MRK
LP
QAVQNQ
GV
TVR-KTGDT
---
N
I
LTI
A
FV
S
TDGSMDKQ
DI
A
D
Y
V
ASN
I
QDP
LS
RVN
GVG
D
I
DAY
G
SQY-SM
RI
W
LDP
AK
LN
SFQ
M
TAKD
V
TD
AI
ESQ
N
AQIAV
GQLGG
T
P
SVDKQALNAT
I
N
A
QSL
LQT
P
E
Q
F
RD
I
T
L
RVNQ
DG
SE
V
R
L
G
DVA
T
VE
M
G
A
E
KYDYL
S
RF
NGK
-
P
A
S
G
LG
V
K
L
AS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQY
FP
H
G
L
E
YKVA
Y
E
TT
SF
V
KA
SI
E
D
VVKT
L
L
EAI
A
LV
F
LV
M
YLFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
S
VL
Y
A
F
G
Y
S
V
N
T
LTM
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
E
GLT
P
RE
A
TR
K
SMG
QIQ
G
AL
VGIAMV
L
S
AVF
V
PM
A
F
FG
G
TT
G
A
IYR
Q
FSIT
IVA
AM
VL
SV
L
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWF
N
QM
F
NRNAER
----
Y
EKGVA
K
I
L
HRSLRW
I
V
I
Y
V
L
LLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IE
K
YY
FTHEKDN
I
M
SVF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFNKIKEAR
V
I--
A
S
-
SPPA
I
SGL
G
SS
A
GFDME
L
QDHAGAGH
D
A
L
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
L
D
DSPQLQ
ID
I
D
QR
KA
Q
A
L
GV
AI
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
ML
P
DD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VG
EA
APGV
S
T
G
M
A
MDIMESLVKQ
L
-
-
P
N
G
FGLE
W
T
A
--
MS
YQ
ER
L
SGAQAPA
L
Y
A
-
I
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NEMN
Q
K-
----------
G
HDLF
EA
TLH
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
S
T
GAGSG
GQHA
VG
T
GVMGGM
IS
A
T
I
LAI
Y
FV
P
LF
F
V
LV
fig|670888.3.peg.3828
Escherichia coli 1827-70 (16-1026/1037)
AI
L
L
C
L
T
G
TLA
I
FS
LPV
E
QYP
D
L
AP
P
N
V
R
V
T
A
N
YPGA
S
AQ
T
L
E
N
T
VT
Q
VIE
QN
M
TG
L
D
N
LM
Y
MSS
Q
S
SGT
G
QAS
V
TL
S
F
K
A
GT
D
PD
E
A
VQ
QVQ
NQ
LQ
S
A
MRK
LP
QAVQNQ
GV
TVR-KTGDT
---
N
I
LTI
A
FV
S
TDGSMDKQ
DI
A
D
Y
V
ASN
I
QDP
LS
RVN
GVG
D
I
DAY
G
SQY-SM
RI
W
LDP
AK
LN
SFQ
M
TAKD
V
TD
AI
ESQ
N
AQIAV
GQLGG
T
P
SVDKQALNAT
I
N
A
QSL
LQT
P
E
Q
F
RD
I
T
L
RVNQ
DG
SE
V
R
L
G
DVA
T
VE
M
G
A
E
KYDYL
S
RF
NGK
-
P
A
S
G
LG
V
K
L
AS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQY
FP
H
G
L
E
YKVA
Y
E
TT
SF
V
KA
SI
E
D
VVKT
L
L
EAI
A
LV
F
LV
M
YLFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
S
VL
Y
A
F
G
Y
S
V
N
T
LTM
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
E
GLT
P
RE
A
TR
K
SMG
QIQ
G
AL
VGIAMV
L
S
AVF
V
PM
A
F
FG
G
TT
G
A
IYR
Q
FSIT
IVA
AM
VL
SV
L
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWF
N
QM
F
NRNAER
----
Y
EKGVA
K
I
L
HRSLRW
I
V
I
Y
V
L
LLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IE
K
YY
FTHEKDN
I
M
SVF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFNKIKEAR
V
I--
A
S
-
SPPA
I
SGL
G
SS
A
GFDME
L
QDHAGAGH
D
A
L
MAARN
QL
LAL
A
AEN
P
-K
L
TR
V
RH
N
G
L
D
DSPQLQ
ID
I
D
QR
KA
Q
A
L
GV
AI
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
ML
P
DD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VG
EA
APGV
S
T
G
T
A
MDIMESLVKQ
L
-
-
P
N
G
FGLE
W
T
A
--
MS
YQ
ER
L
SGAQAPA
L
Y
A
-
I
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NEMN
Q
K-
----------
G
HDLF
EA
TLH
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
S
T
GAGSG
GQHA
VG
T
GVMGGM
IS
A
T
I
LAI
Y
FV
P
LF
F
V
LV
fig|344610.3.peg.415
Escherichia coli 53638 (16-1026/1037)
AI
L
L
C
L
T
G
TLA
I
FS
LPV
E
QYP
D
L
AP
P
N
V
R
V
T
A
N
YPGA
S
AQ
T
L
E
N
T
VT
Q
VIE
QN
M
TG
L
D
N
LM
Y
MSS
Q
S
SGT
G
QAS
V
TL
S
F
K
A
GT
D
PD
E
A
VQ
QVQ
NQ
LQ
S
A
MRK
LP
QAVQNQ
GV
TVR-KTGDT
---
N
I
LTI
A
FV
S
TDGSMDKQ
DI
A
D
Y
V
ASN
I
QDP
LS
RVN
GVG
D
I
DAY
G
SQY-SM
RI
W
LDP
AK
LN
SFQ
M
TAKD
V
TD
AI
ESQ
N
AQIAV
GQLGG
T
P
SVDKQALNAT
I
N
A
QSL
LQT
P
E
Q
F
RD
I
T
L
RVNQ
DG
SE
V
R
L
G
DVA
T
VE
M
G
A
E
KYDYL
S
RF
NGK
-
P
A
S
G
LG
V
K
L
AS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQY
FP
H
G
L
E
YKVA
Y
E
TT
SF
V
KA
SI
E
D
VVKT
L
L
EAI
A
LV
F
LV
M
YLFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
S
VL
Y
A
F
G
Y
S
V
N
T
LTM
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
E
GLT
P
RE
A
TR
K
SMG
QIQ
G
AL
VGIAMV
L
S
AVF
V
PM
A
F
FG
G
TT
G
A
IYR
Q
FSIT
IVA
AM
VL
SV
L
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWF
N
QM
F
NRNAER
----
Y
EKGVA
K
I
L
HRSLRW
I
V
I
Y
V
L
LLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IE
K
YY
FTHEKDN
I
M
SVF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFNQIKEAR
V
I--
A
S
-
SPPA
I
SGL
G
SS
A
GFDME
L
QDHAGAGH
D
A
L
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
L
D
DSPQLQ
ID
I
D
QR
KA
Q
A
L
GV
AI
D
DI
NDT
L
Q
TA
R
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
ML
P
DD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VG
EA
APGV
S
T
G
T
T
MDIMESLVKQ
L
-
-
P
N
G
FGLE
W
T
A
--
MS
YQ
ER
L
SGAQAPA
L
Y
A
-
I
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NEMN
Q
K-
----------
G
HDLF
EA
TLH
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
S
T
GAGSG
GQHA
VG
T
GVMGGM
IS
A
T
I
LAI
Y
FV
P
LF
F
V
LV
fig|344610.7.peg.3865
Escherichia coli 53638 (16-1026/1037)
AI
L
L
C
L
T
G
TLA
I
FS
LPV
E
QYP
D
L
AP
P
N
V
R
V
T
A
N
YPGA
S
AQ
T
L
E
N
T
VT
Q
VIE
QN
M
TG
L
D
N
LM
Y
MSS
Q
S
SGT
G
QAS
V
TL
S
F
K
A
GT
D
PD
E
A
VQ
QVQ
NQ
LQ
S
A
MRK
LP
QAVQNQ
GV
TVR-KTGDT
---
N
I
LTI
A
FV
S
TDGSMDKQ
DI
A
D
Y
V
ASN
I
QDP
LS
RVN
GVG
D
I
DAY
G
SQY-SM
RI
W
LDP
AK
LN
SFQ
M
TAKD
V
TD
AI
ESQ
N
AQIAV
GQLGG
T
P
SVDKQALNAT
I
N
A
QSL
LQT
P
E
Q
F
RD
I
T
L
RVNQ
DG
SE
V
R
L
G
DVA
T
VE
M
G
A
E
KYDYL
S
RF
NGK
-
P
A
S
G
LG
V
K
L
AS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQY
FP
H
G
L
E
YKVA
Y
E
TT
SF
V
KA
SI
E
D
VVKT
L
L
EAI
A
LV
F
LV
M
YLFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
S
VL
Y
A
F
G
Y
S
V
N
T
LTM
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
E
GLT
P
RE
A
TR
K
SMG
QIQ
G
AL
VGIAMV
L
S
AVF
V
PM
A
F
FG
G
TT
G
A
IYR
Q
FSIT
IVA
AM
VL
SV
L
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWF
N
QM
F
NRNAER
----
Y
EKGVA
K
I
L
HRSLRW
I
V
I
Y
V
L
LLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IE
K
YY
FTHEKDN
I
M
SVF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFNQIKEAR
V
I--
A
S
-
SPPA
I
SGL
G
SS
A
GFDME
L
QDHAGAGH
D
A
L
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
L
D
DSPQLQ
ID
I
D
QR
KA
Q
A
L
GV
AI
D
DI
NDT
L
Q
TA
R
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
ML
P
DD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VG
EA
APGV
S
T
G
T
T
MDIMESLVKQ
L
-
-
P
N
G
FGLE
W
T
A
--
MS
YQ
ER
L
SGAQAPA
L
Y
A
-
I
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NEMN
Q
K-
----------
G
HDLF
EA
TLH
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
S
T
GAGSG
GQHA
VG
T
GVMGGM
IS
A
T
I
LAI
Y
FV
P
LF
F
V
LV
fig|749527.3.peg.4775
Escherichia coli MS 21-1 (16-1026/1037)
AI
L
L
C
L
T
G
TLA
I
FS
LPV
E
QYP
D
L
AP
P
N
V
R
V
T
A
N
YPGA
S
AQ
T
L
E
N
T
VT
Q
VIE
QN
M
TG
L
D
N
LM
Y
MSS
Q
S
SGT
G
QAS
V
TL
S
F
K
A
GT
D
PD
E
A
VQ
QVQ
NQ
LQ
S
A
MRK
LP
QAVQNQ
GV
TVR-KTGDT
---
N
I
LTI
A
FV
S
TDGSMDKQ
DI
A
D
Y
V
ASN
I
QDP
LS
RVN
GVG
D
I
DAY
G
SQY-SM
RI
W
LDP
AK
LN
SFQ
M
TAKD
V
TD
AI
ESQ
N
AQIAV
GQLGG
T
P
SVDKQALNAT
I
N
A
QSL
LQT
P
E
Q
F
RD
I
T
L
RVNQ
DG
SE
V
R
L
G
DVA
T
VE
M
G
A
E
KYDYL
S
RF
NGK
-
P
A
S
G
LG
V
K
L
AS
GAN
EMA
T
AQL
V
LNR
L
DE
L
AQY
FP
H
G
L
E
YKVA
Y
E
TT
SF
V
KA
SI
E
D
VVKT
L
L
EAI
A
LV
F
LV
M
YLFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
S
VL
Y
A
F
G
Y
S
V
N
T
LTM
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
E
GLT
P
RE
A
TR
K
SMG
QIQ
G
AL
VGIAMV
L
S
AVF
V
PM
A
F
FG
G
TT
G
A
IYR
Q
FSIT
IVA
AM
VL
SV
L
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWF
N
QM
F
NRNAER
----
Y
EKGVA
K
I
L
HRSLRW
I
V
I
Y
V
L
LLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IE
K
YY
FTHEKDN
I
M
SVF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFNKIKEAR
V
I--
A
S
-
SPPA
I
SGL
G
SS
A
GFDME
L
QDHAGAGH
D
A
L
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
L
D
DSPQLQ
ID
I
D
QR
KA
Q
A
L
GV
AI
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
ML
P
DD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VG
EA
APGV
S
T
G
T
A
MDIMESLVKQ
L
-
-
P
N
G
FGLE
W
T
A
--
MS
YQ
ER
L
SGAQAPA
L
Y
A
-
I
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NEMN
Q
K-
----------
G
HDLF
EA
TLH
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
S
T
GAGSG
GQHA
VG
T
GVMGGM
IS
A
T
I
LAI
Y
FV
P
LF
F
V
LV
fig|6666666.5357.peg.4416
Escherichia coli TY-2482 (16-1026/1037)
AI
L
L
C
L
T
G
TLA
I
FS
LPV
E
QYP
D
L
AP
P
N
V
R
V
T
A
N
YPGA
S
AQ
T
L
E
N
T
VT
Q
VIE
QN
M
TG
L
D
N
LM
Y
MSS
Q
S
SGT
G
QAS
V
TL
S
F
K
A
GT
D
PD
E
A
VQ
QVQ
NQ
LQ
S
A
MRK
LP
QAVQNQ
GV
TVR-KTGDT
---
N
I
LTI
A
FV
S
TDGSMDKQ
DI
A
D
Y
V
ASN
I
QDP
LS
RVN
GVG
D
I
DAY
G
SQY-SM
RI
W
LDP
AK
LN
SFQ
M
TAKD
V
TD
AI
ESQ
N
AQIAV
GQLGG
T
P
SVDKQALNAT
I
N
A
QSL
LQT
P
E
Q
F
RD
I
T
L
RVNQ
DG
SE
V
R
L
G
DVA
T
VE
M
G
A
E
KYDYL
S
RF
NGK
-
P
A
S
G
LG
V
K
L
AS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQY
FP
H
G
L
E
YKVA
Y
E
TT
SF
V
KA
SI
E
D
VVKT
L
L
EAI
A
LV
F
LV
M
YLFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
S
VL
Y
A
F
G
Y
S
V
N
T
LTM
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
E
GLT
P
RE
A
TR
K
SMG
QIQ
G
AL
VGIAMV
L
S
AVF
V
PM
A
F
FG
G
TT
G
A
IYR
Q
FSIT
IVA
AM
VL
SV
L
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWF
N
QM
F
NRNAER
----
Y
EKGVA
K
I
L
HRSLRW
I
V
I
Y
V
L
LLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IE
K
YY
FTHEKDN
I
M
SVF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFNKIKEAR
V
I--
A
S
-
SPPA
I
SGL
G
SS
A
GFDME
L
QDHAGAGH
D
A
L
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
L
D
DSPQLQ
ID
I
D
QR
KA
Q
A
L
GV
AI
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
ML
P
DD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VG
EA
APGV
S
T
G
T
A
MDIMESLVKQ
L
-
-
P
N
G
FGLE
W
T
A
--
MS
YQ
ER
L
SGAQAPA
L
Y
A
-
I
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NEMN
Q
K-
----------
G
HDLF
EA
TLH
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
S
T
GAGSG
GQHA
VG
T
GVMGGM
IS
A
T
I
LAI
Y
FV
P
LF
F
V
LV
fig|585055.6.peg.2782
Escherichia coli 55989 (16-1026/1037)
AI
L
L
C
L
T
G
TLA
I
FS
LPV
E
QYP
D
L
AP
P
N
V
R
V
T
A
N
YPGA
S
AQ
T
L
E
N
T
VT
Q
VIE
QN
M
TG
L
D
N
LM
Y
MSS
Q
S
SGT
G
QAS
V
TL
S
F
K
A
GT
D
PD
E
A
VQ
QVQ
NQ
LQ
S
A
MRK
LP
QAVQNQ
GV
TVR-KTGDT
---
N
I
LTI
A
FV
S
TDGSMDKQ
DI
A
D
Y
V
ASN
I
QDP
LS
RVN
GVG
D
I
DAY
G
SQY-SM
RI
W
LDP
AK
LN
SFQ
M
TAKD
V
TD
AI
ESQ
N
AQIAV
GQLGG
T
P
SVDKQALNAT
I
N
A
QSL
LQT
P
E
Q
F
RD
I
T
L
RVNQ
DG
SE
V
R
L
G
DVA
T
VE
M
G
A
E
KYDYL
S
RF
NGK
-
P
A
S
G
LG
V
K
L
AS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQY
FP
H
G
L
E
YKVA
Y
E
TT
SF
V
KA
SI
E
D
VVKT
L
L
EAI
A
LV
F
LV
M
YLFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
S
VL
Y
A
F
G
Y
S
V
N
T
LTM
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
E
GLT
P
RE
A
TR
K
SMG
QIQ
G
AL
VGIAMV
L
S
AVF
V
PM
A
F
FG
G
TT
G
A
IYR
Q
FSIT
IVA
AM
VL
SV
L
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWF
N
QM
F
NRNAER
----
Y
EKGVA
K
I
L
HRSLRW
I
V
I
Y
V
L
LLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IE
K
YY
FTHEKDN
I
M
SVF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFNKIKEAR
V
I--
A
S
-
SPPA
I
SGL
G
SS
A
GFDME
L
QDHAGAGH
D
A
L
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
L
D
DSPQLQ
ID
I
D
QR
KA
Q
A
L
GV
AI
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
ML
P
DD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VG
EA
APGV
S
T
G
T
A
MDIMESLVKQ
L
-
-
P
N
G
FGLE
W
T
A
--
MS
YQ
ER
L
SGAQAPA
L
Y
A
-
I
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NEMN
Q
K-
----------
G
HDLF
EA
TLH
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
S
T
GAGSG
GQHA
VG
T
GVMGGM
IS
A
T
I
LAI
Y
FV
P
LF
F
V
LV
fig|585055.8.peg.2786
Escherichia coli 55989 (16-1026/1037)
AI
L
L
C
L
T
G
TLA
I
FS
LPV
E
QYP
D
L
AP
P
N
V
R
V
T
A
N
YPGA
S
AQ
T
L
E
N
T
VT
Q
VIE
QN
M
TG
L
D
N
LM
Y
MSS
Q
S
SGT
G
QAS
V
TL
S
F
K
A
GT
D
PD
E
A
VQ
QVQ
NQ
LQ
S
A
MRK
LP
QAVQNQ
GV
TVR-KTGDT
---
N
I
LTI
A
FV
S
TDGSMDKQ
DI
A
D
Y
V
ASN
I
QDP
LS
RVN
GVG
D
I
DAY
G
SQY-SM
RI
W
LDP
AK
LN
SFQ
M
TAKD
V
TD
AI
ESQ
N
AQIAV
GQLGG
T
P
SVDKQALNAT
I
N
A
QSL
LQT
P
E
Q
F
RD
I
T
L
RVNQ
DG
SE
V
R
L
G
DVA
T
VE
M
G
A
E
KYDYL
S
RF
NGK
-
P
A
S
G
LG
V
K
L
AS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQY
FP
H
G
L
E
YKVA
Y
E
TT
SF
V
KA
SI
E
D
VVKT
L
L
EAI
A
LV
F
LV
M
YLFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
S
VL
Y
A
F
G
Y
S
V
N
T
LTM
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
E
GLT
P
RE
A
TR
K
SMG
QIQ
G
AL
VGIAMV
L
S
AVF
V
PM
A
F
FG
G
TT
G
A
IYR
Q
FSIT
IVA
AM
VL
SV
L
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWF
N
QM
F
NRNAER
----
Y
EKGVA
K
I
L
HRSLRW
I
V
I
Y
V
L
LLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IE
K
YY
FTHEKDN
I
M
SVF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFNKIKEAR
V
I--
A
S
-
SPPA
I
SGL
G
SS
A
GFDME
L
QDHAGAGH
D
A
L
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
L
D
DSPQLQ
ID
I
D
QR
KA
Q
A
L
GV
AI
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
ML
P
DD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VG
EA
APGV
S
T
G
T
A
MDIMESLVKQ
L
-
-
P
N
G
FGLE
W
T
A
--
MS
YQ
ER
L
SGAQAPA
L
Y
A
-
I
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NEMN
Q
K-
----------
G
HDLF
EA
TLH
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
S
T
GAGSG
GQHA
VG
T
GVMGGM
IS
A
T
I
LAI
Y
FV
P
LF
F
V
LV
fig|405955.13.peg.2715
Escherichia coli APEC O1 (16-1026/1037)
AI
L
L
C
L
T
G
TLA
I
FS
LPV
E
QYP
D
L
AP
P
N
V
R
V
T
A
N
YPGA
S
AQ
T
L
E
N
T
VT
Q
VIE
QN
M
TG
L
D
N
LM
Y
MSS
Q
S
SGT
G
QAS
V
TL
S
F
K
A
GT
D
PD
E
A
VQ
QVQ
NQ
LQ
S
A
MRK
LP
QAVQNQ
GV
TVR-KTGDT
---
N
I
LTI
A
FV
S
TDGSMDKQ
DI
A
D
Y
V
ASN
I
QDP
LS
RVN
GVG
D
I
DAY
G
SQY-SM
RI
W
LDP
AK
LN
SFQ
M
TAKD
V
TD
AI
ESQ
N
AQIAV
GQLGG
T
P
SVDKQALNAT
I
N
A
QSL
LQT
P
E
Q
F
RD
I
T
L
RVNQ
DG
SE
V
R
L
G
DVA
T
VE
M
G
A
E
KYDYL
S
RF
NGK
-
P
A
S
G
LG
V
K
L
AS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQY
FP
H
G
L
E
YKVA
Y
E
TT
SF
V
KA
SI
E
D
VVKT
L
L
EAI
A
LV
F
LV
M
YLFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
S
VL
Y
A
F
G
Y
S
V
N
T
LTM
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
E
GLT
P
RE
A
TR
K
SMG
QIQ
G
AL
VGIAMV
L
S
AVF
V
PM
A
F
FG
G
TT
G
A
IYR
Q
FSIT
IVA
AM
VL
SV
L
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWF
N
QM
F
NRNAER
----
Y
EKGVA
K
I
L
HRSLRW
I
V
I
Y
V
L
LLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IE
K
YY
FTHEKDN
I
M
SVF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFNKIKEAR
V
I--
A
S
-
SPPA
I
SGL
G
SS
A
GFDME
L
QDHAGAGH
D
A
L
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
L
D
DSPQLQ
ID
I
D
QR
KA
Q
A
L
GV
AI
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
ML
P
DD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VG
EA
APGV
S
T
G
T
A
MDIMESLVKQ
L
-
-
P
N
G
FGLE
W
T
A
--
MS
YQ
ER
L
SGAQAPA
L
Y
A
-
I
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NEMN
Q
K-
----------
G
HDLF
EA
TLH
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
S
T
GAGSG
GQHA
VG
T
GVMGGM
IS
A
T
I
LAI
Y
FV
P
LF
F
V
LV
fig|405955.9.peg.2235
Escherichia coli APEC O1 (16-1026/1037)
AI
L
L
C
L
T
G
TLA
I
FS
LPV
E
QYP
D
L
AP
P
N
V
R
V
T
A
N
YPGA
S
AQ
T
L
E
N
T
VT
Q
VIE
QN
M
TG
L
D
N
LM
Y
MSS
Q
S
SGT
G
QAS
V
TL
S
F
K
A
GT
D
PD
E
A
VQ
QVQ
NQ
LQ
S
A
MRK
LP
QAVQNQ
GV
TVR-KTGDT
---
N
I
LTI
A
FV
S
TDGSMDKQ
DI
A
D
Y
V
ASN
I
QDP
LS
RVN
GVG
D
I
DAY
G
SQY-SM
RI
W
LDP
AK
LN
SFQ
M
TAKD
V
TD
AI
ESQ
N
AQIAV
GQLGG
T
P
SVDKQALNAT
I
N
A
QSL
LQT
P
E
Q
F
RD
I
T
L
RVNQ
DG
SE
V
R
L
G
DVA
T
VE
M
G
A
E
KYDYL
S
RF
NGK
-
P
A
S
G
LG
V
K
L
AS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQY
FP
H
G
L
E
YKVA
Y
E
TT
SF
V
KA
SI
E
D
VVKT
L
L
EAI
A
LV
F
LV
M
YLFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
S
VL
Y
A
F
G
Y
S
V
N
T
LTM
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
E
GLT
P
RE
A
TR
K
SMG
QIQ
G
AL
VGIAMV
L
S
AVF
V
PM
A
F
FG
G
TT
G
A
IYR
Q
FSIT
IVA
AM
VL
SV
L
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWF
N
QM
F
NRNAER
----
Y
EKGVA
K
I
L
HRSLRW
I
V
I
Y
V
L
LLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IE
K
YY
FTHEKDN
I
M
SVF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFNKIKEAR
V
I--
A
S
-
SPPA
I
SGL
G
SS
A
GFDME
L
QDHAGAGH
D
A
L
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
L
D
DSPQLQ
ID
I
D
QR
KA
Q
A
L
GV
AI
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
ML
P
DD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VG
EA
APGV
S
T
G
T
A
MDIMESLVKQ
L
-
-
P
N
G
FGLE
W
T
A
--
MS
YQ
ER
L
SGAQAPA
L
Y
A
-
I
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NEMN
Q
K-
----------
G
HDLF
EA
TLH
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
S
T
GAGSG
GQHA
VG
T
GVMGGM
IS
A
T
I
LAI
Y
FV
P
LF
F
V
LV
fig|481805.3.peg.1293
Escherichia coli ATCC 8739 (16-1026/1037)
AI
L
L
C
L
T
G
TLA
I
FS
LPV
E
QYP
D
L
AP
P
N
V
R
V
T
A
N
YPGA
S
AQ
T
L
E
N
T
VT
Q
VIE
QN
M
TG
L
D
N
LM
Y
MSS
Q
S
SGT
G
QAS
V
TL
S
F
K
A
GT
D
PD
E
A
VQ
QVQ
NQ
LQ
S
A
MRK
LP
QAVQNQ
GV
TVR-KTGDT
---
N
I
LTI
A
FV
S
TDGSMDKQ
DI
A
D
Y
V
ASN
I
QDP
LS
RVN
GVG
D
I
DAY
G
SQY-SM
RI
W
LDP
AK
LN
SFQ
M
TAKD
V
TD
AI
ESQ
N
AQIAV
GQLGG
T
P
SVDKQALNAT
I
N
A
QSL
LQT
P
E
Q
F
RD
I
T
L
RVNQ
DG
SE
V
R
L
G
DVA
T
VE
M
G
A
E
KYDYL
S
RF
NGK
-
P
A
S
G
LG
V
K
L
AS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQY
FP
H
G
L
E
YKVA
Y
E
TT
SF
V
KA
SI
E
D
VVKT
L
L
EAI
A
LV
F
LV
M
YLFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
S
VL
Y
A
F
G
Y
S
V
N
T
LTM
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
E
GLT
P
RE
A
TR
K
SMG
QIQ
G
AL
VGIAMV
L
S
AVF
V
PM
A
F
FG
G
TT
G
A
IYR
Q
FSIT
IVA
AM
VL
SV
L
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWF
N
QM
F
NRNAER
----
Y
EKGVA
K
I
L
HRSLRW
I
V
I
Y
V
L
LLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IE
K
YY
FTHEKDN
I
M
SVF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFNQIKEAR
V
I--
A
S
-
SPPA
I
SGL
G
SS
A
GFDME
L
QDHAGAGH
D
A
L
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
L
D
DSPQLQ
ID
I
D
QR
KA
Q
A
L
GV
AI
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
ML
P
DD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VG
EA
APGV
S
T
G
T
A
MDIMESLVKQ
L
-
-
P
N
G
FGLE
W
T
A
--
MS
YQ
ER
L
SGAQAPA
L
Y
A
-
I
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NEMN
Q
K-
----------
G
HDLF
EA
TLH
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
S
T
GAGSG
GQHA
VG
T
GVMGGM
IS
A
T
I
LAI
Y
FV
P
LF
F
V
LV
fig|481805.6.peg.1292
Escherichia coli ATCC 8739 (16-1026/1037)
AI
L
L
C
L
T
G
TLA
I
FS
LPV
E
QYP
D
L
AP
P
N
V
R
V
T
A
N
YPGA
S
AQ
T
L
E
N
T
VT
Q
VIE
QN
M
TG
L
D
N
LM
Y
MSS
Q
S
SGT
G
QAS
V
TL
S
F
K
A
GT
D
PD
E
A
VQ
QVQ
NQ
LQ
S
A
MRK
LP
QAVQNQ
GV
TVR-KTGDT
---
N
I
LTI
A
FV
S
TDGSMDKQ
DI
A
D
Y
V
ASN
I
QDP
LS
RVN
GVG
D
I
DAY
G
SQY-SM
RI
W
LDP
AK
LN
SFQ
M
TAKD
V
TD
AI
ESQ
N
AQIAV
GQLGG
T
P
SVDKQALNAT
I
N
A
QSL
LQT
P
E
Q
F
RD
I
T
L
RVNQ
DG
SE
V
R
L
G
DVA
T
VE
M
G
A
E
KYDYL
S
RF
NGK
-
P
A
S
G
LG
V
K
L
AS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQY
FP
H
G
L
E
YKVA
Y
E
TT
SF
V
KA
SI
E
D
VVKT
L
L
EAI
A
LV
F
LV
M
YLFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
S
VL
Y
A
F
G
Y
S
V
N
T
LTM
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
E
GLT
P
RE
A
TR
K
SMG
QIQ
G
AL
VGIAMV
L
S
AVF
V
PM
A
F
FG
G
TT
G
A
IYR
Q
FSIT
IVA
AM
VL
SV
L
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWF
N
QM
F
NRNAER
----
Y
EKGVA
K
I
L
HRSLRW
I
V
I
Y
V
L
LLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IE
K
YY
FTHEKDN
I
M
SVF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFNQIKEAR
V
I--
A
S
-
SPPA
I
SGL
G
SS
A
GFDME
L
QDHAGAGH
D
A
L
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
L
D
DSPQLQ
ID
I
D
QR
KA
Q
A
L
GV
AI
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
ML
P
DD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VG
EA
APGV
S
T
G
T
A
MDIMESLVKQ
L
-
-
P
N
G
FGLE
W
T
A
--
MS
YQ
ER
L
SGAQAPA
L
Y
A
-
I
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NEMN
Q
K-
----------
G
HDLF
EA
TLH
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
S
T
GAGSG
GQHA
VG
T
GVMGGM
IS
A
T
I
LAI
Y
FV
P
LF
F
V
LV
fig|413997.3.peg.2471
Escherichia coli B str. REL606 (16-1026/1037)
AI
L
L
C
L
T
G
TLA
I
FS
LPV
E
QYP
D
L
AP
P
N
V
R
V
T
A
N
YPGA
S
AQ
T
L
E
N
T
VT
Q
VIE
QN
M
TG
L
D
N
LM
Y
MSS
Q
S
SGT
G
QAS
V
TL
S
F
K
A
GT
D
PD
E
A
VQ
QVQ
NQ
LQ
S
A
MRK
LP
QAVQNQ
GV
TVR-KTGDT
---
N
I
LTI
A
FV
S
TDGSMDKQ
DI
A
D
Y
V
ASN
I
QDP
LS
RVN
GVG
D
I
DAY
G
SQY-SM
RI
W
LDP
AK
LN
SFQ
M
TAKD
V
TD
AI
ESQ
N
AQIAV
GQLGG
T
P
SVDKQALNAT
I
N
A
QSL
LQT
P
E
Q
F
RD
I
T
L
RVNQ
DG
SE
V
R
L
G
DVA
T
VE
M
G
A
E
KYDYL
S
RF
NGK
-
P
A
S
G
LG
V
K
L
AS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQY
FP
H
G
L
E
YKVA
Y
E
TT
SF
V
KA
SI
E
D
VVKT
L
L
EAI
A
LV
F
LV
M
YLFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
S
VL
Y
A
F
G
Y
S
V
N
T
LTM
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
E
GLT
P
RE
A
TR
K
SMG
QIQ
G
AL
VGIAMV
L
S
AVF
V
PM
A
F
FG
G
TT
G
A
IYR
Q
FSIT
IVA
AM
VL
SV
L
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWF
N
QM
F
NRNAER
----
Y
EKGVA
K
I
L
HRSLRW
I
V
I
Y
V
L
LLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IE
K
YY
FTHEKDN
I
M
SVF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFNQIKEAR
V
I--
A
S
-
SPPA
I
SGL
G
SS
A
GFDME
L
QDHAGAGH
D
A
L
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
L
D
DSPQLQ
ID
I
D
QR
KA
Q
A
L
GV
AI
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
ML
P
DD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VG
EA
APGV
S
T
G
T
A
MDIMESLVKQ
L
-
-
P
N
G
FGLE
W
T
A
--
MS
YQ
ER
L
SGAQAPA
L
Y
A
-
I
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NEMN
Q
K-
----------
G
HDLF
EA
TLH
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
S
T
GAGSG
GQHA
VG
T
GVMGGM
IS
A
T
I
LAI
Y
FV
P
LF
F
V
LV
fig|550676.3.peg.1663
Escherichia coli B185 (16-1026/1037)
AI
L
L
C
L
T
G
TLA
I
FS
LPV
E
QYP
D
L
AP
P
N
V
R
V
T
A
N
YPGA
S
AQ
T
L
E
N
T
VT
Q
VIE
QN
M
TG
L
D
N
LM
Y
MSS
Q
S
SGT
G
QAS
V
TL
S
F
K
A
GT
D
PD
E
A
VQ
QVQ
NQ
LQ
S
A
MRK
LP
QAVQNQ
GV
TVR-KTGDT
---
N
I
LTI
A
FV
S
TDGSMDKQ
DI
A
D
Y
V
ASN
I
QDP
LS
RVN
GVG
D
I
DAY
G
SQY-SM
RI
W
LDP
AK
LN
SFQ
M
TAKD
V
TD
AI
ESQ
N
AQIAV
GQLGG
T
P
SVDKQALNAT
I
N
A
QSL
LQT
P
E
Q
F
RD
I
T
L
RVNQ
DG
SE
V
R
L
G
DVA
T
VE
M
G
A
E
KYDYL
S
RF
NGK
-
P
A
S
G
LG
V
K
L
AS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQY
FP
H
G
L
E
YKVA
Y
E
TT
SF
V
KA
SI
E
D
VVKT
L
L
EAI
A
LV
F
LV
M
YLFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
S
VL
Y
A
F
G
Y
S
V
N
T
LTM
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
E
GLT
P
RE
A
TR
K
SMG
QIQ
G
AL
VGIAMV
L
S
AVF
V
PM
A
F
FG
G
TT
G
A
IYR
Q
FSIT
IVA
AM
VL
SV
L
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWF
N
QM
F
NRNAER
----
Y
EKGVA
K
I
L
HRSLRW
I
V
I
Y
V
L
LLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IE
K
YY
FTHEKDN
I
M
SVF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFNKIKEAR
V
I--
A
S
-
SPPA
I
SGL
G
SS
A
GFDME
L
QDHAGAGH
D
A
L
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
L
D
DSPQLQ
ID
I
D
QR
KA
Q
A
L
GV
AI
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
ML
P
DD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VG
EA
APGV
S
T
G
T
A
MDIMESLVKQ
L
-
-
P
N
G
FGLE
W
T
A
--
MS
YQ
ER
L
SGAQAPA
L
Y
A
-
I
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NEMN
Q
K-
----------
G
HDLF
EA
TLH
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
S
T
GAGSG
GQHA
VG
T
GVMGGM
IS
A
T
I
LAI
Y
FV
P
LF
F
V
LV
fig|550677.3.peg.2332
Escherichia coli B354 (16-1026/1037)
AI
L
L
C
L
T
G
TLA
I
FS
LPV
E
QYP
D
L
AP
P
N
V
R
V
T
A
N
YPGA
S
AQ
T
L
E
N
T
VT
Q
VIE
QN
M
TG
L
D
N
LM
Y
MSS
Q
S
SGT
G
QAS
V
TL
S
F
K
A
GT
D
PD
E
A
VQ
QVQ
NQ
LQ
S
A
MRK
LP
QAVQNQ
GV
TVR-KTGDT
---
N
I
LTI
A
FV
S
TDGSMDKQ
DI
A
D
Y
V
ASN
I
QDP
LS
RVN
GVG
D
I
DAY
G
SQY-SM
RI
W
LDP
AK
LN
SFQ
M
TAKD
V
TD
AI
ESQ
N
AQIAV
GQLGG
T
P
SVDKQALNAT
I
N
A
QSL
LQT
P
E
Q
F
RD
I
T
L
RVNQ
DG
SE
V
R
L
G
DVA
T
VE
M
G
A
E
KYDYL
S
RF
NGK
-
P
A
S
G
LG
V
K
L
AS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQY
FP
H
G
L
E
YKVA
Y
E
TT
SF
V
KA
SI
E
D
VVKT
L
L
EAI
A
LV
F
LV
M
YLFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
S
VL
Y
A
F
G
Y
S
V
N
T
LTM
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
E
GLT
P
RE
A
TR
K
SMG
QIQ
G
AL
VGIAMV
L
S
AVF
V
PM
A
F
FG
G
TT
G
A
IYR
Q
FSIT
IVA
AM
VL
SV
L
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWF
N
QM
F
NRNAER
----
Y
EKGVA
K
I
L
HRSLRW
I
V
I
Y
V
L
LLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IE
K
YY
FTHEKDN
I
M
SVF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFNKIKEAR
V
I--
A
S
-
SPPA
I
SGL
G
SS
A
GFDME
L
QDHAGAGH
D
A
L
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
L
D
DSPQLQ
ID
I
D
QR
KA
Q
A
L
GV
AI
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
ML
P
DD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VG
EA
APGV
S
T
G
T
A
MDIMESLVKQ
L
-
-
P
N
G
FGLE
W
T
A
--
MS
YQ
ER
L
SGAQAPA
L
Y
A
-
I
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NEMN
Q
K-
----------
G
HDLF
EA
TLH
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
S
T
GAGSG
GQHA
VG
T
GVMGGM
IS
A
T
I
LAI
Y
FV
P
LF
F
V
LV
fig|511693.5.peg.2483
Escherichia coli BL21 (16-1026/1037)
AI
L
L
C
L
T
G
TLA
I
FS
LPV
E
QYP
D
L
AP
P
N
V
R
V
T
A
N
YPGA
S
AQ
T
L
E
N
T
VT
Q
VIE
QN
M
TG
L
D
N
LM
Y
MSS
Q
S
SGT
G
QAS
V
TL
S
F
K
A
GT
D
PD
E
A
VQ
QVQ
NQ
LQ
S
A
MRK
LP
QAVQNQ
GV
TVR-KTGDT
---
N
I
LTI
A
FV
S
TDGSMDKQ
DI
A
D
Y
V
ASN
I
QDP
LS
RVN
GVG
D
I
DAY
G
SQY-SM
RI
W
LDP
AK
LN
SFQ
M
TAKD
V
TD
AI
ESQ
N
AQIAV
GQLGG
T
P
SVDKQALNAT
I
N
A
QSL
LQT
P
E
Q
F
RD
I
T
L
RVNQ
DG
SE
V
R
L
G
DVA
T
VE
M
G
A
E
KYDYL
S
RF
NGK
-
P
A
S
G
LG
V
K
L
AS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQY
FP
H
G
L
E
YKVA
Y
E
TT
SF
V
KA
SI
E
D
VVKT
L
L
EAI
A
LV
F
LV
M
YLFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
S
VL
Y
A
F
G
Y
S
V
N
T
LTM
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
E
GLT
P
RE
A
TR
K
SMG
QIQ
G
AL
VGIAMV
L
S
AVF
V
PM
A
F
FG
G
TT
G
A
IYR
Q
FSIT
IVA
AM
VL
SV
L
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWF
N
QM
F
NRNAER
----
Y
EKGVA
K
I
L
HRSLRW
I
V
I
Y
V
L
LLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IE
K
YY
FTHEKDN
I
M
SVF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFNQIKEAR
V
I--
A
S
-
SPPA
I
SGL
G
SS
A
GFDME
L
QDHAGAGH
D
A
L
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
L
D
DSPQLQ
ID
I
D
QR
KA
Q
A
L
GV
AI
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
ML
P
DD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VG
EA
APGV
S
T
G
T
A
MDIMESLVKQ
L
-
-
P
N
G
FGLE
W
T
A
--
MS
YQ
ER
L
SGAQAPA
L
Y
A
-
I
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NEMN
Q
K-
----------
G
HDLF
EA
TLH
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
S
T
GAGSG
GQHA
VG
T
GVMGGM
IS
A
T
I
LAI
Y
FV
P
LF
F
V
LV
fig|469008.4.peg.1253
Escherichia coli BL21(DE3) (16-1026/1037)
AI
L
L
C
L
T
G
TLA
I
FS
LPV
E
QYP
D
L
AP
P
N
V
R
V
T
A
N
YPGA
S
AQ
T
L
E
N
T
VT
Q
VIE
QN
M
TG
L
D
N
LM
Y
MSS
Q
S
SGT
G
QAS
V
TL
S
F
K
A
GT
D
PD
E
A
VQ
QVQ
NQ
LQ
S
A
MRK
LP
QAVQNQ
GV
TVR-KTGDT
---
N
I
LTI
A
FV
S
TDGSMDKQ
DI
A
D
Y
V
ASN
I
QDP
LS
RVN
GVG
D
I
DAY
G
SQY-SM
RI
W
LDP
AK
LN
SFQ
M
TAKD
V
TD
AI
ESQ
N
AQIAV
GQLGG
T
P
SVDKQALNAT
I
N
A
QSL
LQT
P
E
Q
F
RD
I
T
L
RVNQ
DG
SE
V
R
L
G
DVA
T
VE
M
G
A
E
KYDYL
S
RF
NGK
-
P
A
S
G
LG
V
K
L
AS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQY
FP
H
G
L
E
YKVA
Y
E
TT
SF
V
KA
SI
E
D
VVKT
L
L
EAI
A
LV
F
LV
M
YLFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
S
VL
Y
A
F
G
Y
S
V
N
T
LTM
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
E
GLT
P
RE
A
TR
K
SMG
QIQ
G
AL
VGIAMV
L
S
AVF
V
PM
A
F
FG
G
TT
G
A
IYR
Q
FSIT
IVA
AM
VL
SV
L
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWF
N
QM
F
NRNAER
----
Y
EKGVA
K
I
L
HRSLRW
I
V
I
Y
V
L
LLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IE
K
YY
FTHEKDN
I
M
SVF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFNQIKEAR
V
I--
A
S
-
SPPA
I
SGL
G
SS
A
GFDME
L
QDHAGAGH
D
A
L
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
L
D
DSPQLQ
ID
I
D
QR
KA
Q
A
L
GV
AI
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
ML
P
DD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VG
EA
APGV
S
T
G
T
A
MDIMESLVKQ
L
-
-
P
N
G
FGLE
W
T
A
--
MS
YQ
ER
L
SGAQAPA
L
Y
A
-
I
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NEMN
Q
K-
----------
G
HDLF
EA
TLH
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
S
T
GAGSG
GQHA
VG
T
GVMGGM
IS
A
T
I
LAI
Y
FV
P
LF
F
V
LV
fig|595496.3.peg.2446
Escherichia coli BW2952 (16-1026/1037)
AI
L
L
C
L
T
G
TLA
I
FS
LPV
E
QYP
D
L
AP
P
N
V
R
V
T
A
N
YPGA
S
AQ
T
L
E
N
T
VT
Q
VIE
QN
M
TG
L
D
N
LM
Y
MSS
Q
S
SGT
G
QAS
V
TL
S
F
K
A
GT
D
PD
E
A
VQ
QVQ
NQ
LQ
S
A
MRK
LP
QAVQNQ
GV
TVR-KTGDT
---
N
I
LTI
A
FV
S
TDGSMDKQ
DI
A
D
Y
V
ASN
I
QDP
LS
RVN
GVG
D
I
DAY
G
SQY-SM
RI
W
LDP
AK
LN
SFQ
M
TAKD
V
TD
AI
ESQ
N
AQIAV
GQLGG
T
P
SVDKQALNAT
I
N
A
QSL
LQT
P
E
Q
F
RD
I
T
L
RVNQ
DG
SE
V
R
L
G
DVA
T
VE
M
G
A
E
KYDYL
S
RF
NGK
-
P
A
S
G
LG
V
K
L
AS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQY
FP
H
G
L
E
YKVA
Y
E
TT
SF
V
KA
SI
E
D
VVKT
L
L
EAI
A
LV
F
LV
M
YLFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
S
VL
Y
A
F
G
Y
S
V
N
T
LTM
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
E
GLT
P
RE
A
TR
K
SMG
QIQ
G
AL
VGIAMV
L
S
AVF
V
PM
A
F
FG
G
TT
G
A
IYR
Q
FSIT
IVA
AM
VL
SV
L
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWF
N
QM
F
NRNAER
----
Y
EKGVA
K
I
L
HRSLRW
I
V
I
Y
V
L
LLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IE
K
YY
FTHEKDN
I
M
SVF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFNQIKEAR
V
I--
A
S
-
SPPA
I
SGL
G
SS
A
GFDME
L
QDHAGAGH
D
A
L
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
L
D
DSPQLQ
ID
I
D
QR
KA
Q
A
L
GV
AI
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
ML
P
DD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VG
EA
APGV
S
T
G
T
A
MDIMESLVKQ
L
-
-
P
N
G
FGLE
W
T
A
--
MS
YQ
ER
L
SGAQAPA
L
Y
A
-
I
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NEMN
Q
K-
----------
G
HDLF
EA
TLH
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
S
T
GAGSG
GQHA
VG
T
GVMGGM
IS
A
T
I
LAI
Y
FV
P
LF
F
V
LV
fig|536056.3.peg.1263
Escherichia coli DH1 (16-1026/1037)
AI
L
L
C
L
T
G
TLA
I
FS
LPV
E
QYP
D
L
AP
P
N
V
R
V
T
A
N
YPGA
S
AQ
T
L
E
N
T
VT
Q
VIE
QN
M
TG
L
D
N
LM
Y
MSS
Q
S
SGT
G
QAS
V
TL
S
F
K
A
GT
D
PD
E
A
VQ
QVQ
NQ
LQ
S
A
MRK
LP
QAVQNQ
GV
TVR-KTGDT
---
N
I
LTI
A
FV
S
TDGSMDKQ
DI
A
D
Y
V
ASN
I
QDP
LS
RVN
GVG
D
I
DAY
G
SQY-SM
RI
W
LDP
AK
LN
SFQ
M
TAKD
V
TD
AI
ESQ
N
AQIAV
GQLGG
T
P
SVDKQALNAT
I
N
A
QSL
LQT
P
E
Q
F
RD
I
T
L
RVNQ
DG
SE
V
R
L
G
DVA
T
VE
M
G
A
E
KYDYL
S
RF
NGK
-
P
A
S
G
LG
V
K
L
AS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQY
FP
H
G
L
E
YKVA
Y
E
TT
SF
V
KA
SI
E
D
VVKT
L
L
EAI
A
LV
F
LV
M
YLFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
S
VL
Y
A
F
G
Y
S
V
N
T
LTM
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
E
GLT
P
RE
A
TR
K
SMG
QIQ
G
AL
VGIAMV
L
S
AVF
V
PM
A
F
FG
G
TT
G
A
IYR
Q
FSIT
IVA
AM
VL
SV
L
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWF
N
QM
F
NRNAER
----
Y
EKGVA
K
I
L
HRSLRW
I
V
I
Y
V
L
LLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IE
K
YY
FTHEKDN
I
M
SVF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFNQIKEAR
V
I--
A
S
-
SPPA
I
SGL
G
SS
A
GFDME
L
QDHAGAGH
D
A
L
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
L
D
DSPQLQ
ID
I
D
QR
KA
Q
A
L
GV
AI
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
ML
P
DD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VG
EA
APGV
S
T
G
T
A
MDIMESLVKQ
L
-
-
P
N
G
FGLE
W
T
A
--
MS
YQ
ER
L
SGAQAPA
L
Y
A
-
I
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NEMN
Q
K-
----------
G
HDLF
EA
TLH
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
S
T
GAGSG
GQHA
VG
T
GVMGGM
IS
A
T
I
LAI
Y
FV
P
LF
F
V
LV
fig|340185.3.peg.3122
Escherichia coli E22 (16-1026/1037)
AI
L
L
C
L
T
G
TLA
I
FS
LPV
E
QYP
D
L
AP
P
N
V
R
V
T
A
N
YPGA
S
AQ
T
L
E
N
T
VT
Q
VIE
QN
M
TG
L
D
N
LM
Y
MSS
Q
S
SGT
G
QAS
V
TL
S
F
K
A
GT
D
PD
E
A
VQ
QVQ
NQ
LQ
S
A
MRK
LP
QAVQNQ
GV
TVR-KTGDT
---
N
I
LTI
A
FV
S
TDGSMDKQ
DI
A
D
Y
V
ASN
I
QDP
LS
RVN
GVG
D
I
DAY
G
SQY-SM
RI
W
LDP
AK
LN
SFQ
M
TAKD
V
TD
AI
ESQ
N
AQIAV
GQLGG
T
P
SVDKQALNAT
I
N
A
QSL
LQT
P
E
Q
F
RD
I
T
L
RVNQ
DG
SE
V
R
L
G
DVA
T
VE
M
G
A
E
KYDYL
S
RF
NGK
-
P
A
S
G
LG
V
K
L
AS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQY
FP
H
G
L
E
YKVA
Y
E
TT
SF
V
KA
SI
E
D
VVKT
L
L
EAI
A
LV
F
LV
M
YLFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
S
VL
Y
A
F
G
Y
S
V
N
T
LTM
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
E
GLT
P
RE
A
TR
K
SMG
QIQ
G
AL
VGIAMV
L
S
AVF
V
PM
A
F
FG
G
TT
G
A
IYR
Q
FSIT
IVA
AM
VL
SV
L
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWF
N
QM
F
NRNAER
----
Y
EKGVA
K
I
L
HRSLRW
I
V
I
Y
V
L
LLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IE
K
YY
FTHEKDN
I
M
SVF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFNKIKEAR
V
I--
A
S
-
SPPA
I
SGL
G
SS
A
GFDME
L
QDHAGAGH
D
A
L
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
L
D
DSPQLQ
ID
I
D
QR
KA
Q
A
L
GV
AI
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
ML
P
DD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VG
EA
APGV
S
T
G
T
A
MDIMESLVKQ
L
-
-
P
N
G
FGLE
W
T
A
--
MS
YQ
ER
L
SGAQAPA
L
Y
A
-
I
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NEMN
Q
K-
----------
G
HDLF
EA
TLH
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
S
T
GAGSG
GQHA
VG
T
GVMGGM
IS
A
T
I
LAI
Y
FV
P
LF
F
V
LV
fig|340185.4.peg.3285
Escherichia coli E22 (16-1026/1037)
AI
L
L
C
L
T
G
TLA
I
FS
LPV
E
QYP
D
L
AP
P
N
V
R
V
T
A
N
YPGA
S
AQ
T
L
E
N
T
VT
Q
VIE
QN
M
TG
L
D
N
LM
Y
MSS
Q
S
SGT
G
QAS
V
TL
S
F
K
A
GT
D
PD
E
A
VQ
QVQ
NQ
LQ
S
A
MRK
LP
QAVQNQ
GV
TVR-KTGDT
---
N
I
LTI
A
FV
S
TDGSMDKQ
DI
A
D
Y
V
ASN
I
QDP
LS
RVN
GVG
D
I
DAY
G
SQY-SM
RI
W
LDP
AK
LN
SFQ
M
TAKD
V
TD
AI
ESQ
N
AQIAV
GQLGG
T
P
SVDKQALNAT
I
N
A
QSL
LQT
P
E
Q
F
RD
I
T
L
RVNQ
DG
SE
V
R
L
G
DVA
T
VE
M
G
A
E
KYDYL
S
RF
NGK
-
P
A
S
G
LG
V
K
L
AS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQY
FP
H
G
L
E
YKVA
Y
E
TT
SF
V
KA
SI
E
D
VVKT
L
L
EAI
A
LV
F
LV
M
YLFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
S
VL
Y
A
F
G
Y
S
V
N
T
LTM
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
E
GLT
P
RE
A
TR
K
SMG
QIQ
G
AL
VGIAMV
L
S
AVF
V
PM
A
F
FG
G
TT
G
A
IYR
Q
FSIT
IVA
AM
VL
SV
L
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWF
N
QM
F
NRNAER
----
Y
EKGVA
K
I
L
HRSLRW
I
V
I
Y
V
L
LLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IE
K
YY
FTHEKDN
I
M
SVF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFNKIKEAR
V
I--
A
S
-
SPPA
I
SGL
G
SS
A
GFDME
L
QDHAGAGH
D
A
L
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
L
D
DSPQLQ
ID
I
D
QR
KA
Q
A
L
GV
AI
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
ML
P
DD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VG
EA
APGV
S
T
G
T
A
MDIMESLVKQ
L
-
-
P
N
G
FGLE
W
T
A
--
MS
YQ
ER
L
SGAQAPA
L
Y
A
-
I
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NEMN
Q
K-
----------
G
HDLF
EA
TLH
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
S
T
GAGSG
GQHA
VG
T
GVMGGM
IS
A
T
I
LAI
Y
FV
P
LF
F
V
LV
fig|316401.4.peg.2937
Escherichia coli ETEC H10407 (16-1026/1037)
AI
L
L
C
L
T
G
TLA
I
FS
LPV
E
QYP
D
L
AP
P
N
V
R
V
T
A
N
YPGA
S
AQ
T
L
E
N
T
VT
Q
VIE
QN
M
TG
L
D
N
LM
Y
MSS
Q
S
SGT
G
QAS
V
TL
S
F
K
A
GT
D
PD
E
A
VQ
QVQ
NQ
LQ
S
A
MRK
LP
QAVQNQ
GV
TVR-KTGDT
---
N
I
LTI
A
FV
S
TDGSMDKQ
DI
A
D
Y
V
ASN
I
QDP
LS
RVN
GVG
D
I
DAY
G
SQY-SM
RI
W
LDP
AK
LN
SFQ
M
TAKD
V
TD
AI
ESQ
N
AQIAV
GQLGG
T
P
SVDKQALNAT
I
N
A
QSL
LQT
P
E
Q
F
RD
I
T
L
RVNQ
DG
SE
V
R
L
G
DVA
T
VE
M
G
A
E
KYDYL
S
RF
NGK
-
P
A
S
G
LG
V
K
L
AS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQY
FP
H
G
L
E
YKVA
Y
E
TT
SF
V
KA
SI
E
D
VVKT
L
L
EAI
A
LV
F
LV
M
YLFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
S
VL
Y
A
F
G
Y
S
V
N
T
LTM
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
E
GLT
P
RE
A
TR
K
SMG
QIQ
G
AL
VGIAMV
L
S
AVF
V
PM
A
F
FG
G
TT
G
A
IYR
Q
FSIT
IVA
AM
VL
SV
L
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWF
N
QM
F
NRNAER
----
Y
EKGVA
K
I
L
HRSLRW
I
V
I
Y
V
L
LLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IE
K
YY
FTHEKDN
I
M
SVF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFNQIKEAR
V
I--
A
S
-
SPPA
I
SGL
G
SS
A
GFDME
L
QDHAGAGH
D
A
L
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
L
D
DSPQLQ
ID
I
D
QR
KA
Q
A
L
GV
AI
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
ML
P
DD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VG
EA
APGV
S
T
G
T
A
MDIMESLVKQ
L
-
-
P
N
G
FGLE
W
T
A
--
MS
YQ
ER
L
SGAQAPA
L
Y
A
-
I
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NEMN
Q
K-
----------
G
HDLF
EA
TLH
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
S
T
GAGSG
GQHA
VG
T
GVMGGM
IS
A
T
I
LAI
Y
FV
P
LF
F
V
LV
fig|340197.3.peg.3049
Escherichia coli F11 (16-1026/1037)
AI
L
L
C
L
T
G
TLA
I
FS
LPV
E
QYP
D
L
AP
P
N
V
R
V
T
A
N
YPGA
S
AQ
T
L
E
N
T
VT
Q
VIE
QN
M
TG
L
D
N
LM
Y
MSS
Q
S
SGT
G
QAS
V
TL
S
F
K
A
GT
D
PD
E
A
VQ
QVQ
NQ
LQ
S
A
MRK
LP
QAVQNQ
GV
TVR-KTGDT
---
N
I
LTI
A
FV
S
TDGSMDKQ
DI
A
D
Y
V
ASN
I
QDP
LS
RVN
GVG
D
I
DAY
G
SQY-SM
RI
W
LDP
AK
LN
SFQ
M
TAKD
V
TD
AI
ESQ
N
AQIAV
GQLGG
T
P
SVDKQALNAT
I
N
A
QSL
LQT
P
E
Q
F
RD
I
T
L
RVNQ
DG
SE
V
R
L
G
DVA
T
VE
M
G
A
E
KYDYL
S
RF
NGK
-
P
A
S
G
LG
V
K
L
AS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQY
FP
H
G
L
E
YKVA
Y
E
TT
SF
V
KA
SI
E
D
VVKT
L
L
EAI
A
LV
F
LV
M
YLFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
S
VL
Y
A
F
G
Y
S
V
N
T
LTM
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
E
GLT
P
RE
A
TR
K
SMG
QIQ
G
AL
VGIAMV
L
S
AVF
V
PM
A
F
FG
G
TT
G
A
IYR
Q
FSIT
IVA
AM
VL
SV
L
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWF
N
QM
F
NRNAER
----
Y
EKGVA
K
I
L
HRSLRW
I
V
I
Y
V
L
LLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IE
K
YY
FTHEKDN
I
M
SVF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFNKIKEAR
V
I--
A
S
-
SPPA
I
SGL
G
SS
A
GFDME
L
QDHAGAGH
D
A
L
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
L
D
DSPQLQ
ID
I
D
QH
KA
Q
A
L
GV
AI
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
ML
P
DD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VG
EA
APGV
S
T
G
T
A
MDIMESLVKQ
L
-
-
P
N
G
FGLE
W
T
A
--
MS
YQ
ER
L
SGAQAPA
L
Y
A
-
I
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NEMN
Q
K-
----------
G
HDLF
EA
TLH
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
S
T
GAGSG
GQHA
VG
T
GVMGGM
IS
A
T
I
LAI
Y
FV
P
LF
F
V
LV
fig|340197.5.peg.3187
Escherichia coli F11 (16-1026/1037)
AI
L
L
C
L
T
G
TLA
I
FS
LPV
E
QYP
D
L
AP
P
N
V
R
V
T
A
N
YPGA
S
AQ
T
L
E
N
T
VT
Q
VIE
QN
M
TG
L
D
N
LM
Y
MSS
Q
S
SGT
G
QAS
V
TL
S
F
K
A
GT
D
PD
E
A
VQ
QVQ
NQ
LQ
S
A
MRK
LP
QAVQNQ
GV
TVR-KTGDT
---
N
I
LTI
A
FV
S
TDGSMDKQ
DI
A
D
Y
V
ASN
I
QDP
LS
RVN
GVG
D
I
DAY
G
SQY-SM
RI
W
LDP
AK
LN
SFQ
M
TAKD
V
TD
AI
ESQ
N
AQIAV
GQLGG
T
P
SVDKQALNAT
I
N
A
QSL
LQT
P
E
Q
F
RD
I
T
L
RVNQ
DG
SE
V
R
L
G
DVA
T
VE
M
G
A
E
KYDYL
S
RF
NGK
-
P
A
S
G
LG
V
K
L
AS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQY
FP
H
G
L
E
YKVA
Y
E
TT
SF
V
KA
SI
E
D
VVKT
L
L
EAI
A
LV
F
LV
M
YLFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
S
VL
Y
A
F
G
Y
S
V
N
T
LTM
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
E
GLT
P
RE
A
TR
K
SMG
QIQ
G
AL
VGIAMV
L
S
AVF
V
PM
A
F
FG
G
TT
G
A
IYR
Q
FSIT
IVA
AM
VL
SV
L
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWF
N
QM
F
NRNAER
----
Y
EKGVA
K
I
L
HRSLRW
I
V
I
Y
V
L
LLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IE
K
YY
FTHEKDN
I
M
SVF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFNKIKEAR
V
I--
A
S
-
SPPA
I
SGL
G
SS
A
GFDME
L
QDHAGAGH
D
A
L
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
L
D
DSPQLQ
ID
I
D
QH
KA
Q
A
L
GV
AI
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
ML
P
DD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VG
EA
APGV
S
T
G
T
A
MDIMESLVKQ
L
-
-
P
N
G
FGLE
W
T
A
--
MS
YQ
ER
L
SGAQAPA
L
Y
A
-
I
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NEMN
Q
K-
----------
G
HDLF
EA
TLH
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
S
T
GAGSG
GQHA
VG
T
GVMGGM
IS
A
T
I
LAI
Y
FV
P
LF
F
V
LV
fig|585034.4.peg.2485
Escherichia coli IAI1 (16-1026/1037)
AI
L
L
C
L
T
G
TLA
I
FS
LPV
E
QYP
D
L
AP
P
N
V
R
V
T
A
N
YPGA
S
AQ
T
L
E
N
T
VT
Q
VIE
QN
M
TG
L
D
N
LM
Y
MSS
Q
S
SGT
G
QAS
V
TL
S
F
K
A
GT
D
PD
E
A
VQ
QVQ
NQ
LQ
S
A
MRK
LP
QAVQNQ
GV
TVR-KTGDT
---
N
I
LTI
A
FV
S
TDGSMDKQ
DI
A
D
Y
V
ASN
I
QDP
LS
RVN
GVG
D
I
DAY
G
SQY-SM
RI
W
LDP
AK
LN
SFQ
M
TAKD
V
TD
AI
ESQ
N
AQIAV
GQLGG
T
P
SVDKQALNAT
I
N
A
QSL
LQT
P
E
Q
F
RD
I
T
L
RVNQ
DG
SE
V
R
L
G
DVA
T
VE
M
G
A
E
KYDYL
S
RF
NGK
-
P
A
S
G
LG
V
K
L
AS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQY
FP
H
G
L
E
YKVA
Y
E
TT
SF
V
KA
SI
E
D
VVKT
L
L
EAI
A
LV
F
LV
M
YLFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
S
VL
Y
A
F
G
Y
S
V
N
T
LTM
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
E
GLT
P
RE
A
TR
K
SMG
QIQ
G
AL
VGIAMV
L
S
AVF
V
PM
A
F
FG
G
TT
G
A
IYR
Q
FSIT
IVA
AM
VL
SV
L
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWF
N
QM
F
NRNAER
----
Y
EKGVA
K
I
L
HRSLRW
I
V
I
Y
V
L
LLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IE
K
YY
FTHEKDN
I
M
SVF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFNKIKEAR
V
I--
A
S
-
SPPA
I
SGL
G
SS
A
GFDME
L
QDHAGAGH
D
A
L
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
L
D
DSPQLQ
ID
I
D
QR
KA
Q
A
L
GV
AI
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
ML
P
DD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VG
EA
APGV
S
T
G
T
A
MDIMESLVKQ
L
-
-
P
N
G
FGLE
W
T
A
--
MS
YQ
ER
L
SGAQAPA
L
Y
A
-
I
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NEMN
Q
K-
----------
G
HDLF
EA
TLH
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
S
T
GAGSG
GQHA
VG
T
GVMGGM
IS
A
T
I
LAI
Y
FV
P
LF
F
V
LV
fig|585034.5.peg.2483
Escherichia coli IAI1 (16-1026/1037)
AI
L
L
C
L
T
G
TLA
I
FS
LPV
E
QYP
D
L
AP
P
N
V
R
V
T
A
N
YPGA
S
AQ
T
L
E
N
T
VT
Q
VIE
QN
M
TG
L
D
N
LM
Y
MSS
Q
S
SGT
G
QAS
V
TL
S
F
K
A
GT
D
PD
E
A
VQ
QVQ
NQ
LQ
S
A
MRK
LP
QAVQNQ
GV
TVR-KTGDT
---
N
I
LTI
A
FV
S
TDGSMDKQ
DI
A
D
Y
V
ASN
I
QDP
LS
RVN
GVG
D
I
DAY
G
SQY-SM
RI
W
LDP
AK
LN
SFQ
M
TAKD
V
TD
AI
ESQ
N
AQIAV
GQLGG
T
P
SVDKQALNAT
I
N
A
QSL
LQT
P
E
Q
F
RD
I
T
L
RVNQ
DG
SE
V
R
L
G
DVA
T
VE
M
G
A
E
KYDYL
S
RF
NGK
-
P
A
S
G
LG
V
K
L
AS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQY
FP
H
G
L
E
YKVA
Y
E
TT
SF
V
KA
SI
E
D
VVKT
L
L
EAI
A
LV
F
LV
M
YLFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
S
VL
Y
A
F
G
Y
S
V
N
T
LTM
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
E
GLT
P
RE
A
TR
K
SMG
QIQ
G
AL
VGIAMV
L
S
AVF
V
PM
A
F
FG
G
TT
G
A
IYR
Q
FSIT
IVA
AM
VL
SV
L
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWF
N
QM
F
NRNAER
----
Y
EKGVA
K
I
L
HRSLRW
I
V
I
Y
V
L
LLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IE
K
YY
FTHEKDN
I
M
SVF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFNKIKEAR
V
I--
A
S
-
SPPA
I
SGL
G
SS
A
GFDME
L
QDHAGAGH
D
A
L
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
L
D
DSPQLQ
ID
I
D
QR
KA
Q
A
L
GV
AI
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
ML
P
DD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VG
EA
APGV
S
T
G
T
A
MDIMESLVKQ
L
-
-
P
N
G
FGLE
W
T
A
--
MS
YQ
ER
L
SGAQAPA
L
Y
A
-
I
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NEMN
Q
K-
----------
G
HDLF
EA
TLH
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
S
T
GAGSG
GQHA
VG
T
GVMGGM
IS
A
T
I
LAI
Y
FV
P
LF
F
V
LV
fig|585057.4.peg.2710
Escherichia coli IAI39 (16-1026/1037)
AI
L
L
C
L
T
G
TLA
I
FS
LPV
E
QYP
D
L
AP
P
N
V
R
V
T
A
N
YPGA
S
AQ
T
L
E
N
T
VT
Q
VIE
QN
M
TG
L
D
N
LM
Y
MSS
Q
S
SGT
G
QAS
V
TL
S
F
K
A
GT
D
PD
E
A
VQ
QVQ
NQ
LQ
S
A
MRK
LP
QAVQNQ
GV
TVR-KTGDT
---
N
I
LTI
A
FV
S
TDGSMDKQ
DI
A
D
Y
V
ASN
I
QDP
LS
RVN
GVG
D
I
DAY
G
SQY-SM
RI
W
LDP
AK
LN
SFQ
M
TAKD
V
TD
AI
ESQ
N
AQIAV
GQLGG
T
P
SVDKQALNAT
I
N
A
QSL
LQT
P
E
Q
F
RD
I
T
L
RVNQ
DG
SE
V
R
L
G
DVA
T
VE
M
G
A
E
KYDYL
S
RF
NGK
-
P
A
S
G
LG
V
K
L
AS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQY
FP
H
G
L
E
YKVA
Y
E
TT
SF
V
KA
SI
E
D
VVKT
L
L
EAI
A
LV
F
LV
M
YLFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
S
VL
Y
A
F
G
Y
S
V
N
T
LTM
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
E
GLT
P
RE
A
TR
K
SMG
QIQ
G
AL
VGIAMV
L
S
AVF
V
PM
A
F
FG
G
TT
G
A
IYR
Q
FSIT
IVA
AM
VL
SV
L
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWF
N
QM
F
NRNAER
----
Y
EKGVA
K
I
L
HRSLRW
I
V
I
Y
V
L
LLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IE
K
YY
FTHEKDN
I
M
SVF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFNKIKEAR
V
I--
A
S
-
SPPA
I
SGL
G
SS
A
GFDME
L
QDHAGAGH
D
A
L
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
L
D
DSPQLQ
ID
I
D
QR
KA
Q
A
L
GV
AI
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
ML
P
DD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VG
EA
APGV
S
T
G
T
A
MDIMESLVKQ
L
-
-
P
N
G
FGLE
W
T
A
--
MS
YQ
ER
L
SGAQAPA
L
Y
A
-
I
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NEMN
Q
K-
----------
G
HDLF
EA
TLH
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
S
T
GAGSG
GQHA
VG
T
GVMGGM
IS
A
T
I
LAI
Y
FV
P
LF
F
V
LV
fig|585057.6.peg.2713
Escherichia coli IAI39 (16-1026/1037)
AI
L
L
C
L
T
G
TLA
I
FS
LPV
E
QYP
D
L
AP
P
N
V
R
V
T
A
N
YPGA
S
AQ
T
L
E
N
T
VT
Q
VIE
QN
M
TG
L
D
N
LM
Y
MSS
Q
S
SGT
G
QAS
V
TL
S
F
K
A
GT
D
PD
E
A
VQ
QVQ
NQ
LQ
S
A
MRK
LP
QAVQNQ
GV
TVR-KTGDT
---
N
I
LTI
A
FV
S
TDGSMDKQ
DI
A
D
Y
V
ASN
I
QDP
LS
RVN
GVG
D
I
DAY
G
SQY-SM
RI
W
LDP
AK
LN
SFQ
M
TAKD
V
TD
AI
ESQ
N
AQIAV
GQLGG
T
P
SVDKQALNAT
I
N
A
QSL
LQT
P
E
Q
F
RD
I
T
L
RVNQ
DG
SE
V
R
L
G
DVA
T
VE
M
G
A
E
KYDYL
S
RF
NGK
-
P
A
S
G
LG
V
K
L
AS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQY
FP
H
G
L
E
YKVA
Y
E
TT
SF
V
KA
SI
E
D
VVKT
L
L
EAI
A
LV
F
LV
M
YLFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
S
VL
Y
A
F
G
Y
S
V
N
T
LTM
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
E
GLT
P
RE
A
TR
K
SMG
QIQ
G
AL
VGIAMV
L
S
AVF
V
PM
A
F
FG
G
TT
G
A
IYR
Q
FSIT
IVA
AM
VL
SV
L
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWF
N
QM
F
NRNAER
----
Y
EKGVA
K
I
L
HRSLRW
I
V
I
Y
V
L
LLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IE
K
YY
FTHEKDN
I
M
SVF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFNKIKEAR
V
I--
A
S
-
SPPA
I
SGL
G
SS
A
GFDME
L
QDHAGAGH
D
A
L
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
L
D
DSPQLQ
ID
I
D
QR
KA
Q
A
L
GV
AI
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
ML
P
DD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VG
EA
APGV
S
T
G
T
A
MDIMESLVKQ
L
-
-
P
N
G
FGLE
W
T
A
--
MS
YQ
ER
L
SGAQAPA
L
Y
A
-
I
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NEMN
Q
K-
----------
G
HDLF
EA
TLH
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
S
T
GAGSG
GQHA
VG
T
GVMGGM
IS
A
T
I
LAI
Y
FV
P
LF
F
V
LV
fig|714962.3.peg.2822
Escherichia coli IHE3034 (16-1026/1037)
AI
L
L
C
L
T
G
TLA
I
FS
LPV
E
QYP
D
L
AP
P
N
V
R
V
T
A
N
YPGA
S
AQ
T
L
E
N
T
VT
Q
VIE
QN
M
TG
L
D
N
LM
Y
MSS
Q
S
SGT
G
QAS
V
TL
S
F
K
A
GT
D
PD
E
A
VQ
QVQ
NQ
LQ
S
A
MRK
LP
QAVQNQ
GV
TVR-KTGDT
---
N
I
LTI
A
FV
S
TDGSMDKQ
DI
A
D
Y
V
ASN
I
QDP
LS
RVN
GVG
D
I
DAY
G
SQY-SM
RI
W
LDP
AK
LN
SFQ
M
TAKD
V
TD
AI
ESQ
N
AQIAV
GQLGG
T
P
SVDKQALNAT
I
N
A
QSL
LQT
P
E
Q
F
RD
I
T
L
RVNQ
DG
SE
V
R
L
G
DVA
T
VE
M
G
A
E
KYDYL
S
RF
NGK
-
P
A
S
G
LG
V
K
L
AS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQY
FP
H
G
L
E
YKVA
Y
E
TT
SF
V
KA
SI
E
D
VVKT
L
L
EAI
A
LV
F
LV
M
YLFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
S
VL
Y
A
F
G
Y
S
V
N
T
LTM
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
E
GLT
P
RE
A
TR
K
SMG
QIQ
G
AL
VGIAMV
L
S
AVF
V
PM
A
F
FG
G
TT
G
A
IYR
Q
FSIT
IVA
AM
VL
SV
L
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWF
N
QM
F
NRNAER
----
Y
EKGVA
K
I
L
HRSLRW
I
V
I
Y
V
L
LLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IE
K
YY
FTHEKDN
I
M
SVF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFNKIKEAR
V
I--
A
S
-
SPPA
I
SGL
G
SS
A
GFDME
L
QDHAGAGH
D
A
L
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
L
D
DSPQLQ
ID
I
D
QR
KA
Q
A
L
GV
AI
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
ML
P
DD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VG
EA
APGV
S
T
G
T
A
MDIMESLVKQ
L
-
-
P
N
G
FGLE
W
T
A
--
MS
YQ
ER
L
SGAQAPA
L
Y
A
-
I
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NEMN
Q
K-
----------
G
HDLF
EA
TLH
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
S
T
GAGSG
GQHA
VG
T
GVMGGM
IS
A
T
I
LAI
Y
FV
P
LF
F
V
LV
fig|83333.1.peg.2438
Escherichia coli K12 (16-1026/1037)
AI
L
L
C
L
T
G
TLA
I
FS
LPV
E
QYP
D
L
AP
P
N
V
R
V
T
A
N
YPGA
S
AQ
T
L
E
N
T
VT
Q
VIE
QN
M
TG
L
D
N
LM
Y
MSS
Q
S
SGT
G
QAS
V
TL
S
F
K
A
GT
D
PD
E
A
VQ
QVQ
NQ
LQ
S
A
MRK
LP
QAVQNQ
GV
TVR-KTGDT
---
N
I
LTI
A
FV
S
TDGSMDKQ
DI
A
D
Y
V
ASN
I
QDP
LS
RVN
GVG
D
I
DAY
G
SQY-SM
RI
W
LDP
AK
LN
SFQ
M
TAKD
V
TD
AI
ESQ
N
AQIAV
GQLGG
T
P
SVDKQALNAT
I
N
A
QSL
LQT
P
E
Q
F
RD
I
T
L
RVNQ
DG
SE
V
R
L
G
DVA
T
VE
M
G
A
E
KYDYL
S
RF
NGK
-
P
A
S
G
LG
V
K
L
AS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQY
FP
H
G
L
E
YKVA
Y
E
TT
SF
V
KA
SI
E
D
VVKT
L
L
EAI
A
LV
F
LV
M
YLFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
S
VL
Y
A
F
G
Y
S
V
N
T
LTM
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
E
GLT
P
RE
A
TR
K
SMG
QIQ
G
AL
VGIAMV
L
S
AVF
V
PM
A
F
FG
G
TT
G
A
IYR
Q
FSIT
IVA
AM
VL
SV
L
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWF
N
QM
F
NRNAER
----
Y
EKGVA
K
I
L
HRSLRW
I
V
I
Y
V
L
LLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IE
K
YY
FTHEKDN
I
M
SVF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFNQIKEAR
V
I--
A
S
-
SPPA
I
SGL
G
SS
A
GFDME
L
QDHAGAGH
D
A
L
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
L
D
DSPQLQ
ID
I
D
QR
KA
Q
A
L
GV
AI
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
ML
P
DD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VG
EA
APGV
S
T
G
T
A
MDIMESLVKQ
L
-
-
P
N
G
FGLE
W
T
A
--
MS
YQ
ER
L
SGAQAPA
L
Y
A
-
I
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NEMN
Q
K-
----------
G
HDLF
EA
TLH
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
S
T
GAGSG
GQHA
VG
T
GVMGGM
IS
A
T
I
LAI
Y
FV
P
LF
F
V
LV
fig|656417.3.peg.3145
Escherichia coli M605 (16-1026/1037)
AI
L
L
C
L
T
G
TLA
I
FS
LPV
E
QYP
D
L
AP
P
N
V
R
V
T
A
N
YPGA
S
AQ
T
L
E
N
T
VT
Q
VIE
QN
M
TG
L
D
N
LM
Y
MSS
Q
S
SGT
G
QAS
V
TL
S
F
K
A
GT
D
PD
E
A
VQ
QVQ
NQ
LQ
S
A
MRK
LP
QAVQNQ
GV
TVR-KTGDT
---
N
I
LTI
A
FV
S
TDGSMDKQ
DI
A
D
Y
V
ASN
I
QDP
LS
RVN
GVG
D
I
DAY
G
SQY-SM
RI
W
LDP
AK
LN
SFQ
M
TAKD
V
TD
AI
ESQ
N
AQIAV
GQLGG
T
P
SVDKQALNAT
I
N
A
QSL
LQT
P
E
Q
F
RD
I
T
L
RVNQ
DG
SE
V
R
L
G
DVA
T
VE
M
G
A
E
KYDYL
S
RF
NGK
-
P
A
S
G
LG
V
K
L
AS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQY
FP
H
G
L
E
YKVA
Y
E
TT
SF
V
KA
SI
E
D
VVKT
L
L
EAI
A
LV
F
LV
M
YLFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
S
VL
Y
A
F
G
Y
S
V
N
T
LTM
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
E
GLT
P
RE
A
TR
K
SMG
QIQ
G
AL
VGIAMV
L
S
AVF
V
PM
A
F
FG
G
TT
G
A
IYR
Q
FSIT
IVA
AM
VL
SV
L
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWF
N
QM
F
NRNAER
----
Y
EKGVA
K
I
L
HRSLRW
I
V
I
Y
V
L
LLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IE
K
YY
FTHEKDN
I
M
SVF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFNKIKEAR
V
I--
A
S
-
SPPA
I
SGL
G
SS
A
GFDME
L
QDHAGAGH
D
A
L
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
L
D
DSPQLQ
ID
I
D
QR
KA
Q
A
L
GV
AI
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
ML
P
DD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VG
EA
APGV
S
T
G
T
A
MDIMESLVKQ
L
-
-
P
N
G
FGLE
W
T
A
--
MS
YQ
ER
L
SGAQAPA
L
Y
A
-
I
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NEMN
Q
K-
----------
G
HDLF
EA
TLH
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
S
T
GAGSG
GQHA
VG
T
GVMGGM
IS
A
T
I
LAI
Y
FV
P
LF
F
V
LV
fig|656419.3.peg.3228
Escherichia coli M718 (16-1026/1037)
AI
L
L
C
L
T
G
TLA
I
FS
LPV
E
QYP
D
L
AP
P
N
V
R
V
T
A
N
YPGA
S
AQ
T
L
E
N
T
VT
Q
VIE
QN
M
TG
L
D
N
LM
Y
MSS
Q
S
SGT
G
QAS
V
TL
S
F
K
A
GT
D
PD
E
A
VQ
QVQ
NQ
LQ
S
A
MRK
LP
QAVQNQ
GV
TVR-KTGDT
---
N
I
LTI
A
FV
S
TDGSMDKQ
DI
A
D
Y
V
ASN
I
QDP
LS
RVN
GVG
D
I
DAY
G
SQY-SM
RI
W
LDP
AK
LN
SFQ
M
TAKD
V
TD
AI
ESQ
N
AQIAV
GQLGG
T
P
SVDKQALNAT
I
N
A
QSL
LQT
P
E
Q
F
RD
I
T
L
RVNQ
DG
SE
V
R
L
G
DVA
T
VE
M
G
A
E
KYDYL
S
RF
NGK
-
P
A
S
G
LG
V
K
L
AS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQY
FP
H
G
L
E
YKVA
Y
E
TT
SF
V
KA
SI
E
D
VVKT
L
L
EAI
A
LV
F
LV
M
YLFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
S
VL
Y
A
F
G
Y
S
V
N
T
LTM
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
E
GLT
P
RE
A
TR
K
SMG
QIQ
G
AL
VGIAMV
L
S
AVF
V
PM
A
F
FG
G
TT
G
A
IYR
Q
FSIT
IVA
AM
VL
SV
L
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWF
N
QM
F
NRNAER
----
Y
EKGVA
K
I
L
HRSLRW
I
V
I
Y
V
L
LLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IE
K
YY
FTHEKDN
I
M
SVF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFNKIKEAR
V
I--
A
S
-
SPPA
I
SGL
G
SS
A
GFDME
L
QDHAGAGH
D
A
L
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
L
D
DSPQLQ
ID
I
D
QR
KA
Q
A
L
GV
AI
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
ML
P
DD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VG
EA
APGV
S
T
G
T
A
MDIMESLVKQ
L
-
-
P
N
G
FGLE
W
T
A
--
MS
YQ
ER
L
SGAQAPA
L
Y
A
-
I
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NEMN
Q
K-
----------
G
HDLF
EA
TLH
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
S
T
GAGSG
GQHA
VG
T
GVMGGM
IS
A
T
I
LAI
Y
FV
P
LF
F
V
LV
fig|749538.3.peg.4763
Escherichia coli MS 116-1 (16-1026/1037)
AI
L
L
C
L
T
G
TLA
I
FS
LPV
E
QYP
D
L
AP
P
N
V
R
V
T
A
N
YPGA
S
AQ
T
L
E
N
T
VT
Q
VIE
QN
M
TG
L
D
N
LM
Y
MSS
Q
S
SGT
G
QAS
V
TL
S
F
K
A
GT
D
PD
E
A
VQ
QVQ
NQ
LQ
S
A
MRK
LP
QAVQNQ
GV
TVR-KTGDT
---
N
I
LTI
A
FV
S
TDGSMDKQ
DI
A
D
Y
V
ASN
I
QDP
LS
RVN
GVG
D
I
DAY
G
SQY-SM
RI
W
LDP
AK
LN
SFQ
M
TAKD
V
TD
AI
ESQ
N
AQIAV
GQLGG
T
P
SVDKQALNAT
I
N
A
QSL
LQT
P
E
Q
F
RD
I
T
L
RVNQ
DG
SE
V
R
L
G
DVA
T
VE
M
G
A
E
KYDYL
S
RF
NGK
-
P
A
S
G
LG
V
K
L
AS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQY
FP
H
G
L
E
YKVA
Y
E
TT
SF
V
KA
SI
E
D
VVKT
L
L
EAI
A
LV
F
LV
M
YLFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
S
VL
Y
A
F
G
Y
S
V
N
T
LTM
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
E
GLT
P
RE
A
TR
K
SMG
QIQ
G
AL
VGIAMV
L
S
AVF
V
PM
A
F
FG
G
TT
G
A
IYR
Q
FSIT
IVA
AM
VL
SV
L
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWF
N
QM
F
NRNAER
----
Y
EKGVA
K
I
L
HRSLRW
I
V
I
Y
V
L
LLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IE
K
YY
FTHEKDN
I
M
SVF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFNQIKEAR
V
I--
A
S
-
SPPA
I
SGL
G
SS
A
GFDME
L
QDHAGAGH
D
A
L
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
L
D
DSPQLQ
ID
I
D
QR
KA
Q
A
L
GV
AI
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
ML
P
DD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VG
EA
APGV
S
T
G
T
A
MDIMESLVKQ
L
-
-
P
N
G
FGLE
W
T
A
--
MS
YQ
ER
L
SGAQAPA
L
Y
A
-
I
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NEMN
Q
K-
----------
G
HDLF
EA
TLH
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
S
T
GAGSG
GQHA
VG
T
GVMGGM
IS
A
T
I
LAI
Y
FV
P
LF
F
V
LV
fig|749544.3.peg.2847
Escherichia coli MS 175-1 (16-1026/1037)
AI
L
L
C
L
T
G
TLA
I
FS
LPV
E
QYP
D
L
AP
P
N
V
R
V
T
A
N
YPGA
S
AQ
T
L
E
N
T
VT
Q
VIE
QN
M
TG
L
D
N
LM
Y
MSS
Q
S
SGT
G
QAS
V
TL
S
F
K
A
GT
D
PD
E
A
VQ
QVQ
NQ
LQ
S
A
MRK
LP
QAVQNQ
GV
TVR-KTGDT
---
N
I
LTI
A
FV
S
TDGSMDKQ
DI
A
D
Y
V
ASN
I
QDP
LS
RVN
GVG
D
I
DAY
G
SQY-SM
RI
W
LDP
AK
LN
SFQ
M
TAKD
V
TD
AI
ESQ
N
AQIAV
GQLGG
T
P
SVDKQALNAT
I
N
A
QSL
LQT
P
E
Q
F
RD
I
T
L
RVNQ
DG
SE
V
R
L
G
DVA
T
VE
M
G
A
E
KYDYL
S
RF
NGK
-
P
A
S
G
LG
V
K
L
AS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQY
FP
H
G
L
E
YKVA
Y
E
TT
SF
V
KA
SI
E
D
VVKT
L
L
EAI
A
LV
F
LV
M
YLFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
S
VL
Y
A
F
G
Y
S
V
N
T
LTM
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
E
GLT
P
RE
A
TR
K
SMG
QIQ
G
AL
VGIAMV
L
S
AVF
V
PM
A
F
FG
G
TT
G
A
IYR
Q
FSIT
IVA
AM
VL
SV
L
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWF
N
QM
F
NRNAER
----
Y
EKGVA
K
I
L
HRSLRW
I
V
I
Y
V
L
LLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IE
K
YY
FTHEKDN
I
M
SVF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFNQIKEAR
V
I--
A
S
-
SPPA
I
SGL
G
SS
A
GFDME
L
QDHAGAGH
D
A
L
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
L
D
DSPQLQ
ID
I
D
QR
KA
Q
A
L
GV
AI
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
ML
P
DD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VG
EA
APGV
S
T
G
T
A
MDIMESLVKQ
L
-
-
P
N
G
FGLE
W
T
A
--
MS
YQ
ER
L
SGAQAPA
L
Y
A
-
I
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NEMN
Q
K-
----------
G
HDLF
EA
TLH
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
S
T
GAGSG
GQHA
VG
T
GVMGGM
IS
A
T
I
LAI
Y
FV
P
LF
F
V
LV
fig|749547.3.peg.2320
Escherichia coli MS 187-1 (16-1026/1037)
AI
L
L
C
L
T
G
TLA
I
FS
LPV
E
QYP
D
L
AP
P
N
V
R
V
T
A
N
YPGA
S
AQ
T
L
E
N
T
VT
Q
VIE
QN
M
TG
L
D
N
LM
Y
MSS
Q
S
SGT
G
QAS
V
TL
S
F
K
A
GT
D
PD
E
A
VQ
QVQ
NQ
LQ
S
A
MRK
LP
QAVQNQ
GV
TVR-KTGDT
---
N
I
LTI
A
FV
S
TDGSMDKQ
DI
A
D
Y
V
ASN
I
QDP
LS
RVN
GVG
D
I
DAY
G
SQY-SM
RI
W
LDP
AK
LN
SFQ
M
TAKD
V
TD
AI
ESQ
N
AQIAV
GQLGG
T
P
SVDKQALNAT
I
N
A
QSL
LQT
P
E
Q
F
RD
I
T
L
RVNQ
DG
SE
V
R
L
G
DVA
T
VE
M
G
A
E
KYDYL
S
RF
NGK
-
P
A
S
G
LG
V
K
L
AS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQY
FP
H
G
L
E
YKVA
Y
E
TT
SF
V
KA
SI
E
D
VVKT
L
L
EAI
A
LV
F
LV
M
YLFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
S
VL
Y
A
F
G
Y
S
V
N
T
LTM
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
E
GLT
P
RE
A
TR
K
SMG
QIQ
G
AL
VGIAMV
L
S
AVF
V
PM
A
F
FG
G
TT
G
A
IYR
Q
FSIT
IVA
AM
VL
SV
L
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWF
N
QM
F
NRNAER
----
Y
EKGVA
K
I
L
HRSLRW
I
V
I
Y
V
L
LLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IE
K
YY
FTHEKDN
I
M
SVF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFNQIKEAR
V
I--
A
S
-
SPPA
I
SGL
G
SS
A
GFDME
L
QDHAGAGH
D
A
L
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
L
D
DSPQLQ
ID
I
D
QR
KA
Q
A
L
GV
AI
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
ML
P
DD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VG
EA
APGV
S
T
G
T
A
MDIMESLVKQ
L
-
-
P
N
G
FGLE
W
T
A
--
MS
YQ
ER
L
SGAQAPA
L
Y
A
-
I
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NEMN
Q
K-
----------
G
HDLF
EA
TLH
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
S
T
GAGSG
GQHA
VG
T
GVMGGM
IS
A
T
I
LAI
Y
FV
P
LF
F
V
LV
fig|749550.3.peg.5137
Escherichia coli MS 200-1 (16-1026/1037)
AI
L
L
C
L
T
G
TLA
I
FS
LPV
E
QYP
D
L
AP
P
N
V
R
V
T
A
N
YPGA
S
AQ
T
L
E
N
T
VT
Q
VIE
QN
M
TG
L
D
N
LM
Y
MSS
Q
S
SGT
G
QAS
V
TL
S
F
K
A
GT
D
PD
E
A
VQ
QVQ
NQ
LQ
S
A
MRK
LP
QAVQNQ
GV
TVR-KTGDT
---
N
I
LTI
A
FV
S
TDGSMDKQ
DI
A
D
Y
V
ASN
I
QDP
LS
RVN
GVG
D
I
DAY
G
SQY-SM
RI
W
LDP
AK
LN
SFQ
M
TAKD
V
TD
AI
ESQ
N
AQIAV
GQLGG
T
P
SVDKQALNAT
I
N
A
QSL
LQT
P
E
Q
F
RD
I
T
L
RVNQ
DG
SE
V
R
L
G
DVA
T
VE
M
G
A
E
KYDYL
S
RF
NGK
-
P
A
S
G
LG
V
K
L
AS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQY
FP
H
G
L
E
YKVA
Y
E
TT
SF
V
KA
SI
E
D
VVKT
L
L
EAI
A
LV
F
LV
M
YLFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
S
VL
Y
A
F
G
Y
S
V
N
T
LTM
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
E
GLT
P
RE
A
TR
K
SMG
QIQ
G
AL
VGIAMV
L
S
AVF
V
PM
A
F
FG
G
TT
G
A
IYR
Q
FSIT
IVA
AM
VL
SV
L
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWF
N
QM
F
NRNAER
----
Y
EKGVA
K
I
L
HRSLRW
I
V
I
Y
V
L
LLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IE
K
YY
FTHEKDN
I
M
SVF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFNKIKEAR
V
I--
A
S
-
SPPA
I
SGL
G
SS
A
GFDME
L
QDHAGAGH
D
A
L
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
L
D
DSPQLQ
ID
I
D
QR
KA
Q
A
L
GV
AI
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
ML
P
DD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VG
EA
APGV
S
T
G
T
A
MDIMESLVKQ
L
-
-
P
N
G
FGLE
W
T
A
--
MS
YQ
ER
L
SGAQAPA
L
Y
A
-
I
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NEMN
Q
K-
----------
G
HDLF
EA
TLH
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
S
T
GAGSG
GQHA
VG
T
GVMGGM
IS
A
T
I
LAI
Y
FV
P
LF
F
V
LV
fig|753642.3.peg.2636
Escherichia coli NC101 (16-1026/1037)
AI
L
L
C
L
T
G
TLA
I
FS
LPV
E
QYP
D
L
AP
P
N
V
R
V
T
A
N
YPGA
S
AQ
T
L
E
N
T
VT
Q
VIE
QN
M
TG
L
D
N
LM
Y
MSS
Q
S
SGT
G
QAS
V
TL
S
F
K
A
GT
D
PD
E
A
VQ
QVQ
NQ
LQ
S
A
MRK
LP
QAVQNQ
GV
TVR-KTGDT
---
N
I
LTI
A
FV
S
TDGSMDKQ
DI
A
D
Y
V
ASN
I
QDP
LS
RVN
GVG
D
I
DAY
G
SQY-SM
RI
W
LDP
AK
LN
SFQ
M
TAKD
V
TD
AI
ESQ
N
AQIAV
GQLGG
T
P
SVDKQALNAT
I
N
A
QSL
LQT
P
E
Q
F
RD
I
T
L
RVNQ
DG
SE
V
R
L
G
DVA
T
VE
M
G
A
E
KYDYL
S
RF
NGK
-
P
A
S
G
LG
V
K
L
AS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQY
FP
H
G
L
E
YKVA
Y
E
TT
SF
V
KA
SI
E
D
VVKT
L
L
EAI
A
LV
F
LV
M
YLFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
S
VL
Y
A
F
G
Y
S
V
N
T
LTM
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
E
GLT
P
RE
A
TR
K
SMG
QIQ
G
AL
VGIAMV
L
S
AVF
V
PM
A
F
FG
G
TT
G
A
IYR
Q
FSIT
IVA
AM
VL
SV
L
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWF
N
QM
F
NRNAER
----
Y
EKGVA
K
I
L
HRSLRW
I
V
I
Y
V
L
LLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IE
K
YY
FTHEKDN
I
M
SVF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFNKIKEAR
V
I--
A
S
-
SPPA
I
SGL
G
SS
A
GFDME
L
QDHAGAGH
D
A
L
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
L
D
DSPQLQ
ID
I
D
QR
KA
Q
A
L
GV
AI
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
ML
P
DD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VG
EA
APGV
S
T
G
T
A
MDIMESLVKQ
L
-
-
P
N
G
FGLE
W
T
A
--
MS
YQ
ER
L
SGAQAPA
L
Y
A
-
I
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NEMN
Q
K-
----------
G
HDLF
EA
TLH
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
S
T
GAGSG
GQHA
VG
T
GVMGGM
IS
A
T
I
LAI
Y
FV
P
LF
F
V
LV
fig|585395.4.peg.3117
Escherichia coli O103:H2 str. 12009 (16-1026/1037)
AI
L
L
C
L
T
G
TLA
I
FS
LPV
E
QYP
D
L
AP
P
N
V
R
V
T
A
N
YPGA
S
AQ
T
L
E
N
T
VT
Q
VIE
QN
M
TG
L
D
N
LM
Y
MSS
Q
S
SGT
G
QAS
V
TL
S
F
K
A
GT
D
PD
E
A
VQ
QVQ
NQ
LQ
S
A
MRK
LP
QAVQNQ
GV
TVR-KTGDT
---
N
I
LTI
A
FV
S
TDGSMDKQ
DI
A
D
Y
V
ASN
I
QDP
LS
RVN
GVG
D
I
DAY
G
SQY-SM
RI
W
LDP
AK
LN
SFQ
M
TAKD
V
TD
AI
ESQ
N
AQIAV
GQLGG
T
P
SVDKQALNAT
I
N
A
QSL
LQT
P
E
Q
F
RD
I
T
L
RVNQ
DG
SE
V
R
L
G
DVA
T
VE
M
G
A
E
KYDYL
S
RF
NGK
-
P
A
S
G
LG
V
K
L
AS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQY
FP
H
G
L
E
YKVA
Y
E
TT
SF
V
KA
SI
E
D
VVKT
L
L
EAI
A
LV
F
LV
M
YLFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
S
VL
Y
A
F
G
Y
S
V
N
T
LTM
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
E
GLT
P
RE
A
TR
K
SMG
QIQ
G
AL
VGIAMV
L
S
AVF
V
PM
A
F
FG
G
TT
G
A
IYR
Q
FSIT
IVA
AM
VL
SV
L
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWF
N
QM
F
NRNAER
----
Y
EKGVA
K
I
L
HRSLRW
I
V
I
Y
V
L
LLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IE
K
YY
FTHEKDN
I
M
SVF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFNKIKEAR
V
I--
A
S
-
SPPA
I
SGL
G
SS
A
GFDME
L
QDHAGAGH
D
A
L
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
L
D
DSPQLQ
ID
I
D
QR
KA
Q
A
L
GV
AI
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
ML
P
DD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VG
EA
APGV
S
T
G
T
A
MDIMESLVKQ
L
-
-
P
N
G
FGLE
W
T
A
--
MS
YQ
ER
L
SGAQAPA
L
Y
A
-
I
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NEMN
Q
K-
----------
G
HDLF
EA
TLH
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
S
T
GAGSG
GQHA
VG
T
GVMGGM
IS
A
T
I
LAI
Y
FV
P
LF
F
V
LV
fig|585396.4.peg.3291
Escherichia coli O111:H- str. 11128 (16-1026/1037)
AI
L
L
C
L
T
G
TLA
I
FS
LPV
E
QYP
D
L
AP
P
N
V
R
V
T
A
N
YPGA
S
AQ
T
L
E
N
T
VT
Q
VIE
QN
M
TG
L
D
N
LM
Y
MSS
Q
S
SGT
G
QAS
V
TL
S
F
K
A
GT
D
PD
E
A
VQ
QVQ
NQ
LQ
S
A
MRK
LP
QAVQNQ
GV
TVR-KTGDT
---
N
I
LTI
A
FV
S
TDGSMDKQ
DI
A
D
Y
V
ASN
I
QDP
LS
RVN
GVG
D
I
DAY
G
SQY-SM
RI
W
LDP
AK
LN
SFQ
M
TAKD
V
TD
AI
ESQ
N
AQIAV
GQLGG
T
P
SVDKQALNAT
I
N
A
QSL
LQT
P
E
Q
F
RD
I
T
L
RVNQ
DG
SE
V
R
L
G
DVA
T
VE
M
G
A
E
KYDYL
S
RF
NGK
-
P
A
S
G
LG
V
K
L
AS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQY
FP
H
G
L
E
YKVA
Y
E
TT
SF
V
KA
SI
E
D
VVKT
L
L
EAI
A
LV
F
LV
M
YLFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
S
VL
Y
A
F
G
Y
S
V
N
T
LTM
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
E
GLT
P
RE
A
TR
K
SMG
QIQ
G
AL
VGIAMV
L
S
AVF
V
PM
A
F
FG
G
TT
G
A
IYR
Q
FSIT
IVA
AM
VL
SV
L
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWF
N
QM
F
NRNAER
----
Y
EKGVA
K
I
L
HRSLRW
I
V
I
Y
V
L
LLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IE
K
YY
FTHEKDN
I
M
SVF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFNQIKEAR
V
I--
A
S
-
SPPA
I
SGL
G
SS
A
GFDME
L
QDHAGAGH
D
A
L
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
L
D
DSPQLQ
ID
I
D
QR
KA
Q
A
L
GV
AI
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
ML
P
DD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VG
EA
APGV
S
T
G
T
A
MDIMESLVKQ
L
-
-
P
N
G
FGLE
W
T
A
--
MS
YQ
ER
L
SGAQAPA
L
Y
A
-
I
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NEMN
Q
K-
----------
G
HDLF
EA
TLH
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
S
T
GAGSG
GQHA
VG
T
GVMGGM
IS
A
T
I
LAI
Y
FV
P
LF
F
V
LV
fig|573235.3.peg.3579
Escherichia coli O26:H11 str. 11368 (16-1026/1037)
AI
L
L
C
L
T
G
TLA
I
FS
LPV
E
QYP
D
L
AP
P
N
V
R
V
T
A
N
YPGA
S
AQ
T
L
E
N
T
VT
Q
VIE
QN
M
TG
L
D
N
LM
Y
MSS
Q
S
SGT
G
QAS
V
TL
S
F
K
A
GT
D
PD
E
A
VQ
QVQ
NQ
LQ
S
A
MRK
LP
QAVQNQ
GV
TVR-KTGDT
---
N
I
LTI
A
FV
S
TDGSMDKQ
DI
A
D
Y
V
ASN
I
QDP
LS
RVN
GVG
D
I
DAY
G
SQY-SM
RI
W
LDP
AK
LN
SFQ
M
TAKD
V
TD
AI
ESQ
N
AQIAV
GQLGG
T
P
SVDKQALNAT
I
N
A
QSL
LQT
P
E
Q
F
RD
I
T
L
RVNQ
DG
SE
V
R
L
G
DVA
T
VE
M
G
A
E
KYDYL
S
RF
NGK
-
P
A
S
G
LG
V
K
L
AS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQY
FP
H
G
L
E
YKVA
Y
E
TT
SF
V
KA
SI
E
D
VVKT
L
L
EAI
A
LV
F
LV
M
YLFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
S
VL
Y
A
F
G
Y
S
V
N
T
LTM
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
E
GLT
P
RE
A
TR
K
SMG
QIQ
G
AL
VGIAMV
L
S
AVF
V
PM
A
F
FG
G
TT
G
A
IYR
Q
FSIT
IVA
AM
VL
SV
L
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWF
N
QM
F
NRNAER
----
Y
EKGVA
K
I
L
HRSLRW
I
V
I
Y
V
L
LLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IE
K
YY
FTHEKDN
I
M
SVF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFNQIKEAR
V
I--
A
S
-
SPPA
I
SGL
G
SS
A
GFDME
L
QDHAGAGH
D
A
L
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
L
D
DSPQLQ
ID
I
D
QR
KA
Q
A
L
GV
AI
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
ML
P
DD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VG
EA
APGV
S
T
G
T
A
MDIMESLVKQ
L
-
-
P
N
G
FGLE
W
T
A
--
MS
YQ
ER
L
SGAQAPA
L
Y
A
-
I
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NEMN
Q
K-
----------
G
HDLF
EA
TLH
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
S
T
GAGSG
GQHA
VG
T
GVMGGM
IS
A
T
I
LAI
Y
FV
P
LF
F
V
LV
fig|701177.3.peg.3023
Escherichia coli O55:H7 str. CB9615 (16-1026/1037)
AI
L
L
C
L
T
G
TLA
I
FS
LPV
E
QYP
D
L
AP
P
N
V
R
V
T
A
N
YPGA
S
AQ
T
L
E
N
T
VT
Q
VIE
QN
M
TG
L
D
N
LM
Y
MSS
Q
S
SGT
G
QAS
V
TL
S
F
K
A
GT
D
PD
E
A
VQ
QVQ
NQ
LQ
S
A
MRK
LP
QAVQNQ
GV
TVR-KTGDT
---
N
I
LTI
A
FV
S
TDGSMDKQ
DI
A
D
Y
V
ASN
I
QDP
LS
RVN
GVG
D
I
DAY
G
SQY-SM
RI
W
LDP
AK
LN
SFQ
M
TAKD
V
TD
AI
ESQ
N
AQIAV
GQLGG
T
P
SVDKQALNAT
I
N
A
QSL
LQT
P
E
Q
F
RD
I
T
L
RVNQ
DG
SE
V
R
L
G
DVA
T
VE
M
G
A
E
KYDYL
S
RF
NGK
-
P
A
S
G
LG
V
K
L
AS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQY
FP
H
G
L
E
YKVA
Y
E
TT
SF
V
KA
SI
E
D
VVKT
L
L
EAI
A
LV
F
LV
M
YLFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
S
VL
Y
A
F
G
Y
S
V
N
T
LTM
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
E
GLT
P
RE
A
TR
K
SMG
QIQ
G
AL
VGIAMV
L
S
AVF
V
PM
A
F
FG
G
TT
G
A
IYR
Q
FSIT
IVA
AM
VL
SV
L
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWF
N
QM
F
NRNAER
----
Y
EKGVA
K
I
L
HRSLRW
I
V
I
Y
V
L
LLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IE
K
YY
FTHEKDN
I
M
SVF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFNQIKEAR
V
I--
A
S
-
SPPA
I
SGL
G
SS
A
GFDME
L
QDHAGAGH
D
A
L
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
L
D
DSPQLQ
ID
I
D
QR
KA
Q
A
L
GV
AI
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
ML
P
DD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VG
EA
APGV
S
T
G
T
A
MDIMESLVKQ
L
-
-
P
N
G
FGLE
W
T
A
--
MS
YQ
ER
L
SGAQAPA
L
Y
A
-
I
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NEMN
Q
K-
----------
G
HDLF
EA
TLH
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
S
T
GAGSG
GQHA
VG
T
GVMGGM
IS
A
T
I
LAI
Y
FV
P
LF
F
V
LV
fig|585035.6.peg.2620
Escherichia coli S88 (16-1026/1037)
AI
L
L
C
L
T
G
TLA
I
FS
LPV
E
QYP
D
L
AP
P
N
V
R
V
T
A
N
YPGA
S
AQ
T
L
E
N
T
VT
Q
VIE
QN
M
TG
L
D
N
LM
Y
MSS
Q
S
SGT
G
QAS
V
TL
S
F
K
A
GT
D
PD
E
A
VQ
QVQ
NQ
LQ
S
A
MRK
LP
QAVQNQ
GV
TVR-KTGDT
---
N
I
LTI
A
FV
S
TDGSMDKQ
DI
A
D
Y
V
ASN
I
QDP
LS
RVN
GVG
D
I
DAY
G
SQY-SM
RI
W
LDP
AK
LN
SFQ
M
TAKD
V
TD
AI
ESQ
N
AQIAV
GQLGG
T
P
SVDKQALNAT
I
N
A
QSL
LQT
P
E
Q
F
RD
I
T
L
RVNQ
DG
SE
V
R
L
G
DVA
T
VE
M
G
A
E
KYDYL
S
RF
NGK
-
P
A
S
G
LG
V
K
L
AS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQY
FP
H
G
L
E
YKVA
Y
E
TT
SF
V
KA
SI
E
D
VVKT
L
L
EAI
A
LV
F
LV
M
YLFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
S
VL
Y
A
F
G
Y
S
V
N
T
LTM
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
E
GLT
P
RE
A
TR
K
SMG
QIQ
G
AL
VGIAMV
L
S
AVF
V
PM
A
F
FG
G
TT
G
A
IYR
Q
FSIT
IVA
AM
VL
SV
L
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWF
N
QM
F
NRNAER
----
Y
EKGVA
K
I
L
HRSLRW
I
V
I
Y
V
L
LLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IE
K
YY
FTHEKDN
I
M
SVF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFNKIKEAR
V
I--
A
S
-
SPPA
I
SGL
G
SS
A
GFDME
L
QDHAGAGH
D
A
L
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
L
D
DSPQLQ
ID
I
D
QR
KA
Q
A
L
GV
AI
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
ML
P
DD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VG
EA
APGV
S
T
G
T
A
MDIMESLVKQ
L
-
-
P
N
G
FGLE
W
T
A
--
MS
YQ
ER
L
SGAQAPA
L
Y
A
-
I
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NEMN
Q
K-
----------
G
HDLF
EA
TLH
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
S
T
GAGSG
GQHA
VG
T
GVMGGM
IS
A
T
I
LAI
Y
FV
P
LF
F
V
LV
fig|431946.3.peg.2428
Escherichia coli SE15 (16-1026/1037)
AI
L
L
C
L
T
G
TLA
I
FS
LPV
E
QYP
D
L
AP
P
N
V
R
V
T
A
N
YPGA
S
AQ
T
L
E
N
T
VT
Q
VIE
QN
M
TG
L
D
N
LM
Y
MSS
Q
S
SGT
G
QAS
V
TL
S
F
K
A
GT
D
PD
E
A
VQ
QVQ
NQ
LQ
S
A
MRK
LP
QAVQNQ
GV
TVR-KTGDT
---
N
I
LTI
A
FV
S
TDGSMDKQ
DI
A
D
Y
V
ASN
I
QDP
LS
RVN
GVG
D
I
DAY
G
SQY-SM
RI
W
LDP
AK
LN
SFQ
M
TAKD
V
TD
AI
ESQ
N
AQIAV
GQLGG
T
P
SVDKQALNAT
I
N
A
QSL
LQT
P
E
Q
F
RD
I
T
L
RVNQ
DG
SE
V
R
L
G
DVA
T
VE
M
G
A
E
KYDYL
S
RF
NGK
-
P
A
S
G
LG
V
K
L
AS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQY
FP
H
G
L
E
YKVA
Y
E
TT
SF
V
KA
SI
E
D
VVKT
L
L
EAI
A
LV
F
LV
M
YLFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
S
VL
Y
A
F
G
Y
S
V
N
T
LTM
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
E
GLT
P
RE
A
TR
K
SMG
QIQ
G
AL
VGIAMV
L
S
AVF
V
PM
A
F
FG
G
TT
G
A
IYR
Q
FSIT
IVA
AM
VL
SV
L
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWF
N
QM
F
NRNAER
----
Y
EKGVA
K
I
L
HRSLRW
I
V
I
Y
V
L
LLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IE
K
YY
FTHEKDN
I
M
SVF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFNKIKEAR
V
I--
A
S
-
SPPA
I
SGL
G
SS
A
GFDME
L
QDHAGAGH
D
A
L
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
L
D
DSPQLQ
ID
I
D
QR
KA
Q
A
L
GV
AI
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
ML
P
DD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VG
EA
APGV
S
T
G
T
A
MDIMESLVKQ
L
-
-
P
N
G
FGLE
W
T
A
--
MS
YQ
ER
L
SGAQAPA
L
Y
A
-
I
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NEMN
Q
K-
----------
G
HDLF
EA
TLH
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
S
T
GAGSG
GQHA
VG
T
GVMGGM
IS
A
T
I
LAI
Y
FV
P
LF
F
V
LV
fig|869729.3.peg.928
Escherichia coli UM146 (16-1026/1037)
AI
L
L
C
L
T
G
TLA
I
FS
LPV
E
QYP
D
L
AP
P
N
V
R
V
T
A
N
YPGA
S
AQ
T
L
E
N
T
VT
Q
VIE
QN
M
TG
L
D
N
LM
Y
MSS
Q
S
SGT
G
QAS
V
TL
S
F
K
A
GT
D
PD
E
A
VQ
QVQ
NQ
LQ
S
A
MRK
LP
QAVQNQ
GV
TVR-KTGDT
---
N
I
LTI
A
FV
S
TDGSMDKQ
DI
A
D
Y
V
ASN
I
QDP
LS
RVN
GVG
D
I
DAY
G
SQY-SM
RI
W
LDP
AK
LN
SFQ
M
TAKD
V
TD
AI
ESQ
N
AQIAV
GQLGG
T
P
SVDKQALNAT
I
N
A
QSL
LQT
P
E
Q
F
RD
I
T
L
RVNQ
DG
SE
V
R
L
G
DVA
T
VE
M
G
A
E
KYDYL
S
RF
NGK
-
P
A
S
G
LG
V
K
L
AS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQY
FP
H
G
L
E
YKVA
Y
E
TT
SF
V
KA
SI
E
D
VVKT
L
L
EAI
A
LV
F
LV
M
YLFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
S
VL
Y
A
F
G
Y
S
V
N
T
LTM
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
E
GLT
P
RE
A
TR
K
SMG
QIQ
G
AL
VGIAMV
L
S
AVF
V
PM
A
F
FG
G
TT
G
A
IYR
Q
FSIT
IVA
AM
VL
SV
L
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWF
N
QM
F
NRNAER
----
Y
EKGVA
K
I
L
HRSLRW
I
V
I
Y
V
L
LLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IE
K
YY
FTHEKDN
I
M
SVF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFNKIKEAR
V
I--
A
S
-
SPPA
I
SGL
G
SS
A
GFDME
L
QDHAGAGH
D
A
L
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
L
D
DSPQLQ
ID
I
D
QR
KA
Q
A
L
GV
AI
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
ML
P
DD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VG
EA
APGV
S
T
G
T
A
MDIMESLVKQ
L
-
-
P
N
G
FGLE
W
T
A
--
MS
YQ
ER
L
SGAQAPA
L
Y
A
-
I
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NEMN
Q
K-
----------
G
HDLF
EA
TLH
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
S
T
GAGSG
GQHA
VG
T
GVMGGM
IS
A
T
I
LAI
Y
FV
P
LF
F
V
LV
fig|364106.7.peg.2801
Escherichia coli UTI89 (16-1026/1037)
AI
L
L
C
L
T
G
TLA
I
FS
LPV
E
QYP
D
L
AP
P
N
V
R
V
T
A
N
YPGA
S
AQ
T
L
E
N
T
VT
Q
VIE
QN
M
TG
L
D
N
LM
Y
MSS
Q
S
SGT
G
QAS
V
TL
S
F
K
A
GT
D
PD
E
A
VQ
QVQ
NQ
LQ
S
A
MRK
LP
QAVQNQ
GV
TVR-KTGDT
---
N
I
LTI
A
FV
S
TDGSMDKQ
DI
A
D
Y
V
ASN
I
QDP
LS
RVN
GVG
D
I
DAY
G
SQY-SM
RI
W
LDP
AK
LN
SFQ
M
TAKD
V
TD
AI
ESQ
N
AQIAV
GQLGG
T
P
SVDKQALNAT
I
N
A
QSL
LQT
P
E
Q
F
RD
I
T
L
RVNQ
DG
SE
V
R
L
G
DVA
T
VE
M
G
A
E
KYDYL
S
RF
NGK
-
P
A
S
G
LG
V
K
L
AS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQY
FP
H
G
L
E
YKVA
Y
E
TT
SF
V
KA
SI
E
D
VVKT
L
L
EAI
A
LV
F
LV
M
YLFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
S
VL
Y
A
F
G
Y
S
V
N
T
LTM
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
E
GLT
P
RE
A
TR
K
SMG
QIQ
G
AL
VGIAMV
L
S
AVF
V
PM
A
F
FG
G
TT
G
A
IYR
Q
FSIT
IVA
AM
VL
SV
L
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWF
N
QM
F
NRNAER
----
Y
EKGVA
K
I
L
HRSLRW
I
V
I
Y
V
L
LLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IE
K
YY
FTHEKDN
I
M
SVF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFNKIKEAR
V
I--
A
S
-
SPPA
I
SGL
G
SS
A
GFDME
L
QDHAGAGH
D
A
L
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
L
D
DSPQLQ
ID
I
D
QR
KA
Q
A
L
GV
AI
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
ML
P
DD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VG
EA
APGV
S
T
G
T
A
MDIMESLVKQ
L
-
-
P
N
G
FGLE
W
T
A
--
MS
YQ
ER
L
SGAQAPA
L
Y
A
-
I
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NEMN
Q
K-
----------
G
HDLF
EA
TLH
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
S
T
GAGSG
GQHA
VG
T
GVMGGM
IS
A
T
I
LAI
Y
FV
P
LF
F
V
LV
fig|364106.8.peg.2801
Escherichia coli UTI89 (16-1026/1037)
AI
L
L
C
L
T
G
TLA
I
FS
LPV
E
QYP
D
L
AP
P
N
V
R
V
T
A
N
YPGA
S
AQ
T
L
E
N
T
VT
Q
VIE
QN
M
TG
L
D
N
LM
Y
MSS
Q
S
SGT
G
QAS
V
TL
S
F
K
A
GT
D
PD
E
A
VQ
QVQ
NQ
LQ
S
A
MRK
LP
QAVQNQ
GV
TVR-KTGDT
---
N
I
LTI
A
FV
S
TDGSMDKQ
DI
A
D
Y
V
ASN
I
QDP
LS
RVN
GVG
D
I
DAY
G
SQY-SM
RI
W
LDP
AK
LN
SFQ
M
TAKD
V
TD
AI
ESQ
N
AQIAV
GQLGG
T
P
SVDKQALNAT
I
N
A
QSL
LQT
P
E
Q
F
RD
I
T
L
RVNQ
DG
SE
V
R
L
G
DVA
T
VE
M
G
A
E
KYDYL
S
RF
NGK
-
P
A
S
G
LG
V
K
L
AS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQY
FP
H
G
L
E
YKVA
Y
E
TT
SF
V
KA
SI
E
D
VVKT
L
L
EAI
A
LV
F
LV
M
YLFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
S
VL
Y
A
F
G
Y
S
V
N
T
LTM
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
E
GLT
P
RE
A
TR
K
SMG
QIQ
G
AL
VGIAMV
L
S
AVF
V
PM
A
F
FG
G
TT
G
A
IYR
Q
FSIT
IVA
AM
VL
SV
L
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWF
N
QM
F
NRNAER
----
Y
EKGVA
K
I
L
HRSLRW
I
V
I
Y
V
L
LLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IE
K
YY
FTHEKDN
I
M
SVF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFNKIKEAR
V
I--
A
S
-
SPPA
I
SGL
G
SS
A
GFDME
L
QDHAGAGH
D
A
L
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
L
D
DSPQLQ
ID
I
D
QR
KA
Q
A
L
GV
AI
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
ML
P
DD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VG
EA
APGV
S
T
G
T
A
MDIMESLVKQ
L
-
-
P
N
G
FGLE
W
T
A
--
MS
YQ
ER
L
SGAQAPA
L
Y
A
-
I
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NEMN
Q
K-
----------
G
HDLF
EA
TLH
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
S
T
GAGSG
GQHA
VG
T
GVMGGM
IS
A
T
I
LAI
Y
FV
P
LF
F
V
LV
fig|316407.3.peg.2391
Escherichia coli W3110 (16-1026/1037)
AI
L
L
C
L
T
G
TLA
I
FS
LPV
E
QYP
D
L
AP
P
N
V
R
V
T
A
N
YPGA
S
AQ
T
L
E
N
T
VT
Q
VIE
QN
M
TG
L
D
N
LM
Y
MSS
Q
S
SGT
G
QAS
V
TL
S
F
K
A
GT
D
PD
E
A
VQ
QVQ
NQ
LQ
S
A
MRK
LP
QAVQNQ
GV
TVR-KTGDT
---
N
I
LTI
A
FV
S
TDGSMDKQ
DI
A
D
Y
V
ASN
I
QDP
LS
RVN
GVG
D
I
DAY
G
SQY-SM
RI
W
LDP
AK
LN
SFQ
M
TAKD
V
TD
AI
ESQ
N
AQIAV
GQLGG
T
P
SVDKQALNAT
I
N
A
QSL
LQT
P
E
Q
F
RD
I
T
L
RVNQ
DG
SE
V
R
L
G
DVA
T
VE
M
G
A
E
KYDYL
S
RF
NGK
-
P
A
S
G
LG
V
K
L
AS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQY
FP
H
G
L
E
YKVA
Y
E
TT
SF
V
KA
SI
E
D
VVKT
L
L
EAI
A
LV
F
LV
M
YLFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
S
VL
Y
A
F
G
Y
S
V
N
T
LTM
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
E
GLT
P
RE
A
TR
K
SMG
QIQ
G
AL
VGIAMV
L
S
AVF
V
PM
A
F
FG
G
TT
G
A
IYR
Q
FSIT
IVA
AM
VL
SV
L
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWF
N
QM
F
NRNAER
----
Y
EKGVA
K
I
L
HRSLRW
I
V
I
Y
V
L
LLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IE
K
YY
FTHEKDN
I
M
SVF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFNQIKEAR
V
I--
A
S
-
SPPA
I
SGL
G
SS
A
GFDME
L
QDHAGAGH
D
A
L
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
L
D
DSPQLQ
ID
I
D
QR
KA
Q
A
L
GV
AI
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
ML
P
DD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VG
EA
APGV
S
T
G
T
A
MDIMESLVKQ
L
-
-
P
N
G
FGLE
W
T
A
--
MS
YQ
ER
L
SGAQAPA
L
Y
A
-
I
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NEMN
Q
K-
----------
G
HDLF
EA
TLH
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
S
T
GAGSG
GQHA
VG
T
GVMGGM
IS
A
T
I
LAI
Y
FV
P
LF
F
V
LV
fig|562.376.peg.4385
Escherichia coli WV_060327 (16-1026/1037)
AI
L
L
C
L
T
G
TLA
I
FS
LPV
E
QYP
D
L
AP
P
N
V
R
V
T
A
N
YPGA
S
AQ
T
L
E
N
T
VT
Q
VIE
QN
M
TG
L
D
N
LM
Y
MSS
Q
S
SGT
G
QAS
V
TL
S
F
K
A
GT
D
PD
E
A
VQ
QVQ
NQ
LQ
S
A
MRK
LP
QAVQNQ
GV
TVR-KTGDT
---
N
I
LTI
A
FV
S
TDGSMDKQ
DI
A
D
Y
V
ASN
I
QDP
LS
RVN
GVG
D
I
DAY
G
SQY-SM
RI
W
LDP
AK
LN
SFQ
M
TAKD
V
TD
AI
ESQ
N
AQIAV
GQLGG
T
P
SVDKQALNAT
I
N
A
QSL
LQT
P
E
Q
F
RD
I
T
L
RVNQ
DG
SE
V
R
L
G
DVA
T
VE
M
G
A
E
KYDYL
S
RF
NGK
-
P
A
S
G
LG
V
K
L
AS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQY
FP
H
G
L
E
YKVA
Y
E
TT
SF
V
KA
SI
E
D
VVKT
L
L
EAI
A
LV
F
LV
M
YLFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
S
VL
Y
A
F
G
Y
S
V
N
T
LTM
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
E
GLT
P
RE
A
TR
K
SMG
QIQ
G
AL
VGIAMV
L
S
AVF
V
PM
A
F
FG
G
TT
G
A
IYR
Q
FSIT
IVA
AM
VL
SV
L
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWF
N
QM
F
NRNAER
----
Y
EKGVA
K
I
L
HRSLRW
I
V
I
Y
V
L
LLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IE
K
YY
FTHEKDN
I
M
SVF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFNKIKEAR
V
I--
A
S
-
SPPA
I
SGL
G
SS
A
GFDME
L
QDHAGAGH
D
A
L
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
L
D
DSPQLQ
ID
I
D
QR
KA
Q
A
L
GV
AI
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
ML
P
DD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VG
EA
APGV
S
T
G
T
A
MDIMESLVKQ
L
-
-
P
N
G
FGLE
W
T
A
--
MS
YQ
ER
L
SGAQAPA
L
Y
A
-
I
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NEMN
Q
K-
----------
G
HDLF
EA
TLH
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
S
T
GAGSG
GQHA
VG
T
GVMGGM
IS
A
T
I
LAI
Y
FV
P
LF
F
V
LV
fig|316385.7.peg.2658
Escherichia coli str. K-12 substr. DH10B (16-1026/1037)
AI
L
L
C
L
T
G
TLA
I
FS
LPV
E
QYP
D
L
AP
P
N
V
R
V
T
A
N
YPGA
S
AQ
T
L
E
N
T
VT
Q
VIE
QN
M
TG
L
D
N
LM
Y
MSS
Q
S
SGT
G
QAS
V
TL
S
F
K
A
GT
D
PD
E
A
VQ
QVQ
NQ
LQ
S
A
MRK
LP
QAVQNQ
GV
TVR-KTGDT
---
N
I
LTI
A
FV
S
TDGSMDKQ
DI
A
D
Y
V
ASN
I
QDP
LS
RVN
GVG
D
I
DAY
G
SQY-SM
RI
W
LDP
AK
LN
SFQ
M
TAKD
V
TD
AI
ESQ
N
AQIAV
GQLGG
T
P
SVDKQALNAT
I
N
A
QSL
LQT
P
E
Q
F
RD
I
T
L
RVNQ
DG
SE
V
R
L
G
DVA
T
VE
M
G
A
E
KYDYL
S
RF
NGK
-
P
A
S
G
LG
V
K
L
AS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQY
FP
H
G
L
E
YKVA
Y
E
TT
SF
V
KA
SI
E
D
VVKT
L
L
EAI
A
LV
F
LV
M
YLFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
S
VL
Y
A
F
G
Y
S
V
N
T
LTM
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
E
GLT
P
RE
A
TR
K
SMG
QIQ
G
AL
VGIAMV
L
S
AVF
V
PM
A
F
FG
G
TT
G
A
IYR
Q
FSIT
IVA
AM
VL
SV
L
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWF
N
QM
F
NRNAER
----
Y
EKGVA
K
I
L
HRSLRW
I
V
I
Y
V
L
LLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IE
K
YY
FTHEKDN
I
M
SVF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFNQIKEAR
V
I--
A
S
-
SPPA
I
SGL
G
SS
A
GFDME
L
QDHAGAGH
D
A
L
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
L
D
DSPQLQ
ID
I
D
QR
KA
Q
A
L
GV
AI
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
ML
P
DD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VG
EA
APGV
S
T
G
T
A
MDIMESLVKQ
L
-
-
P
N
G
FGLE
W
T
A
--
MS
YQ
ER
L
SGAQAPA
L
Y
A
-
I
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NEMN
Q
K-
----------
G
HDLF
EA
TLH
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
S
T
GAGSG
GQHA
VG
T
GVMGGM
IS
A
T
I
LAI
Y
FV
P
LF
F
V
LV
fig|511145.12.peg.2564
Escherichia coli str. K-12 substr. MG1655 (16-1026/1037)
AI
L
L
C
L
T
G
TLA
I
FS
LPV
E
QYP
D
L
AP
P
N
V
R
V
T
A
N
YPGA
S
AQ
T
L
E
N
T
VT
Q
VIE
QN
M
TG
L
D
N
LM
Y
MSS
Q
S
SGT
G
QAS
V
TL
S
F
K
A
GT
D
PD
E
A
VQ
QVQ
NQ
LQ
S
A
MRK
LP
QAVQNQ
GV
TVR-KTGDT
---
N
I
LTI
A
FV
S
TDGSMDKQ
DI
A
D
Y
V
ASN
I
QDP
LS
RVN
GVG
D
I
DAY
G
SQY-SM
RI
W
LDP
AK
LN
SFQ
M
TAKD
V
TD
AI
ESQ
N
AQIAV
GQLGG
T
P
SVDKQALNAT
I
N
A
QSL
LQT
P
E
Q
F
RD
I
T
L
RVNQ
DG
SE
V
R
L
G
DVA
T
VE
M
G
A
E
KYDYL
S
RF
NGK
-
P
A
S
G
LG
V
K
L
AS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQY
FP
H
G
L
E
YKVA
Y
E
TT
SF
V
KA
SI
E
D
VVKT
L
L
EAI
A
LV
F
LV
M
YLFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
S
VL
Y
A
F
G
Y
S
V
N
T
LTM
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
E
GLT
P
RE
A
TR
K
SMG
QIQ
G
AL
VGIAMV
L
S
AVF
V
PM
A
F
FG
G
TT
G
A
IYR
Q
FSIT
IVA
AM
VL
SV
L
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWF
N
QM
F
NRNAER
----
Y
EKGVA
K
I
L
HRSLRW
I
V
I
Y
V
L
LLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IE
K
YY
FTHEKDN
I
M
SVF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFNQIKEAR
V
I--
A
S
-
SPPA
I
SGL
G
SS
A
GFDME
L
QDHAGAGH
D
A
L
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
L
D
DSPQLQ
ID
I
D
QR
KA
Q
A
L
GV
AI
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
ML
P
DD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VG
EA
APGV
S
T
G
T
A
MDIMESLVKQ
L
-
-
P
N
G
FGLE
W
T
A
--
MS
YQ
ER
L
SGAQAPA
L
Y
A
-
I
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NEMN
Q
K-
----------
G
HDLF
EA
TLH
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
S
T
GAGSG
GQHA
VG
T
GVMGGM
IS
A
T
I
LAI
Y
FV
P
LF
F
V
LV
fig|511145.6.peg.2550
Escherichia coli str. K-12 substr. MG1655 (16-1026/1037)
AI
L
L
C
L
T
G
TLA
I
FS
LPV
E
QYP
D
L
AP
P
N
V
R
V
T
A
N
YPGA
S
AQ
T
L
E
N
T
VT
Q
VIE
QN
M
TG
L
D
N
LM
Y
MSS
Q
S
SGT
G
QAS
V
TL
S
F
K
A
GT
D
PD
E
A
VQ
QVQ
NQ
LQ
S
A
MRK
LP
QAVQNQ
GV
TVR-KTGDT
---
N
I
LTI
A
FV
S
TDGSMDKQ
DI
A
D
Y
V
ASN
I
QDP
LS
RVN
GVG
D
I
DAY
G
SQY-SM
RI
W
LDP
AK
LN
SFQ
M
TAKD
V
TD
AI
ESQ
N
AQIAV
GQLGG
T
P
SVDKQALNAT
I
N
A
QSL
LQT
P
E
Q
F
RD
I
T
L
RVNQ
DG
SE
V
R
L
G
DVA
T
VE
M
G
A
E
KYDYL
S
RF
NGK
-
P
A
S
G
LG
V
K
L
AS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQY
FP
H
G
L
E
YKVA
Y
E
TT
SF
V
KA
SI
E
D
VVKT
L
L
EAI
A
LV
F
LV
M
YLFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
S
VL
Y
A
F
G
Y
S
V
N
T
LTM
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
E
GLT
P
RE
A
TR
K
SMG
QIQ
G
AL
VGIAMV
L
S
AVF
V
PM
A
F
FG
G
TT
G
A
IYR
Q
FSIT
IVA
AM
VL
SV
L
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWF
N
QM
F
NRNAER
----
Y
EKGVA
K
I
L
HRSLRW
I
V
I
Y
V
L
LLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IE
K
YY
FTHEKDN
I
M
SVF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFNQIKEAR
V
I--
A
S
-
SPPA
I
SGL
G
SS
A
GFDME
L
QDHAGAGH
D
A
L
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
L
D
DSPQLQ
ID
I
D
QR
KA
Q
A
L
GV
AI
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
ML
P
DD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VG
EA
APGV
S
T
G
T
A
MDIMESLVKQ
L
-
-
P
N
G
FGLE
W
T
A
--
MS
YQ
ER
L
SGAQAPA
L
Y
A
-
I
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NEMN
Q
K-
----------
G
HDLF
EA
TLH
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
S
T
GAGSG
GQHA
VG
T
GVMGGM
IS
A
T
I
LAI
Y
FV
P
LF
F
V
LV
fig|340186.3.peg.1585
Escherichia coli E110019 (16-1026/1037)
AI
L
L
C
L
T
G
TLA
I
FS
LPV
E
QYP
D
L
AP
P
N
V
R
V
T
A
N
YPGA
S
AQ
T
L
E
N
T
VT
Q
VIE
QN
M
TG
L
D
N
LM
Y
MSS
Q
S
SGT
G
QAS
V
TL
S
F
K
A
GT
D
PD
E
A
VQ
QVQ
NQ
LQ
S
A
MRK
LP
QAVQNQ
GV
TVR-KTGDT
---
N
I
LTI
A
FV
S
TDGSMDKQ
DI
A
D
Y
V
ASN
I
QDP
LS
RVN
GVG
D
I
DAY
G
SQY-SM
RI
W
LDP
AK
LN
SFQ
M
TAKD
V
TD
AI
ESQ
N
AQIAV
GQLGG
T
P
SVDKQALNAT
I
N
A
QSL
LQT
P
E
Q
F
RD
I
T
L
RVNQ
DG
SE
V
R
L
G
DVA
T
VE
M
G
A
E
KYDYL
S
RF
NGK
-
P
A
S
G
LG
V
K
L
AS
GAN
EMA
T
AEL
V
LNR
L
DD
L
AQY
FP
H
G
L
E
YKVA
Y
E
TT
SF
V
KA
SI
E
D
VVKT
L
L
EAI
A
LV
F
LV
M
YLFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
S
VL
Y
A
F
G
Y
S
V
N
T
LTM
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
E
GLT
P
RE
A
TR
K
SMG
QIQ
G
AL
VGIAMV
L
S
AVF
V
PM
A
F
FG
G
TT
G
A
IYR
Q
FSIT
IVA
AM
VL
SV
L
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWF
N
QM
F
NRNAER
----
Y
EKGVA
K
I
L
HRSLRW
I
V
I
Y
V
L
LLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IE
K
YY
FTHEKDN
I
M
SVF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFNKIKEAR
V
I--
A
S
-
SPPA
I
SGL
G
SS
A
GFDME
L
QDHAGAGH
D
A
L
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
L
D
DSPQLQ
ID
I
D
QR
KA
Q
A
L
GV
AI
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
ML
P
DD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VG
EA
APGV
S
T
G
T
A
MDIMESLVKQ
L
-
-
P
N
G
FGLE
W
T
A
--
MS
YQ
ER
L
SGAQAPA
L
Y
A
-
I
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NEMN
Q
K-
----------
G
HDLF
EA
TLH
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
S
T
GAGSG
GQHA
VG
T
GVMGGM
IS
A
T
I
LAI
Y
FV
P
LF
F
V
LV
fig|340186.5.peg.1634
Escherichia coli E110019 (16-1026/1037)
AI
L
L
C
L
T
G
TLA
I
FS
LPV
E
QYP
D
L
AP
P
N
V
R
V
T
A
N
YPGA
S
AQ
T
L
E
N
T
VT
Q
VIE
QN
M
TG
L
D
N
LM
Y
MSS
Q
S
SGT
G
QAS
V
TL
S
F
K
A
GT
D
PD
E
A
VQ
QVQ
NQ
LQ
S
A
MRK
LP
QAVQNQ
GV
TVR-KTGDT
---
N
I
LTI
A
FV
S
TDGSMDKQ
DI
A
D
Y
V
ASN
I
QDP
LS
RVN
GVG
D
I
DAY
G
SQY-SM
RI
W
LDP
AK
LN
SFQ
M
TAKD
V
TD
AI
ESQ
N
AQIAV
GQLGG
T
P
SVDKQALNAT
I
N
A
QSL
LQT
P
E
Q
F
RD
I
T
L
RVNQ
DG
SE
V
R
L
G
DVA
T
VE
M
G
A
E
KYDYL
S
RF
NGK
-
P
A
S
G
LG
V
K
L
AS
GAN
EMA
T
AEL
V
LNR
L
DD
L
AQY
FP
H
G
L
E
YKVA
Y
E
TT
SF
V
KA
SI
E
D
VVKT
L
L
EAI
A
LV
F
LV
M
YLFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
S
VL
Y
A
F
G
Y
S
V
N
T
LTM
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
E
GLT
P
RE
A
TR
K
SMG
QIQ
G
AL
VGIAMV
L
S
AVF
V
PM
A
F
FG
G
TT
G
A
IYR
Q
FSIT
IVA
AM
VL
SV
L
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWF
N
QM
F
NRNAER
----
Y
EKGVA
K
I
L
HRSLRW
I
V
I
Y
V
L
LLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IE
K
YY
FTHEKDN
I
M
SVF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFNKIKEAR
V
I--
A
S
-
SPPA
I
SGL
G
SS
A
GFDME
L
QDHAGAGH
D
A
L
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
L
D
DSPQLQ
ID
I
D
QR
KA
Q
A
L
GV
AI
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
ML
P
DD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VG
EA
APGV
S
T
G
T
A
MDIMESLVKQ
L
-
-
P
N
G
FGLE
W
T
A
--
MS
YQ
ER
L
SGAQAPA
L
Y
A
-
I
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NEMN
Q
K-
----------
G
HDLF
EA
TLH
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
S
T
GAGSG
GQHA
VG
T
GVMGGM
IS
A
T
I
LAI
Y
FV
P
LF
F
V
LV
fig|749546.3.peg.459
Escherichia coli MS 185-1 (16-1026/1037)
AI
L
L
C
L
T
G
TLA
I
FS
LPV
E
QYP
D
L
AP
P
N
V
R
V
T
A
N
YPGA
S
AQ
T
L
E
N
T
VT
Q
VIE
QN
M
TG
L
D
N
LM
Y
MSS
Q
S
SGT
G
QAS
V
TL
S
F
K
A
GT
D
PD
E
A
VQ
QVQ
NQ
LQ
S
A
MRK
LP
QAVQNQ
GV
TVR-KTGDT
---
N
I
LTI
A
FV
S
TDGSMDKQ
DI
A
D
Y
V
ASN
I
QDP
LS
RVN
GVG
D
I
DAY
G
SQY-SM
RI
W
LDP
AK
LN
SFQ
M
TAKD
V
TD
AI
ESQ
N
AQIAV
GQLGG
T
P
SVDKQALNAT
I
N
A
QSL
LQT
P
E
Q
F
RD
I
T
L
RVNQ
DG
SE
V
R
L
G
DVA
T
VE
M
G
A
E
KYDYL
S
RF
NGK
-
P
A
S
G
LG
V
K
L
AS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQY
FP
H
G
L
E
YKVA
Y
E
TT
SF
V
KA
SI
E
D
VVKT
L
L
EAI
A
LV
F
LV
M
YLFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
S
VL
Y
A
F
G
Y
S
V
N
T
LTM
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
E
GLT
P
RE
A
TR
K
SMG
QIQ
G
AL
VGIAMV
L
S
AVF
V
PM
T
F
FG
G
TT
G
A
IYR
Q
FSIT
IVA
AM
VL
SV
L
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWF
N
QM
F
NRNSER
----
Y
EKGVA
K
I
L
HRSLRW
I
V
I
Y
V
L
LLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IE
K
YY
FTHEKDN
I
M
SVF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFNKIKEAR
V
I--
A
S
-
SPPA
I
SGL
G
SS
A
GFDME
L
QDHAGAGH
D
A
L
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
L
D
DSPQLQ
ID
I
D
QR
KA
Q
A
L
GV
AI
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
ML
P
DD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VG
EA
APGV
S
T
G
T
A
MDIMESLVKQ
L
-
-
P
N
G
FGLE
W
T
A
--
MS
YQ
ER
L
SGAQAPA
L
Y
A
-
I
S
L
L
V
VFL
C
L
AA
LYES
RSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NEMN
Q
K-
----------
G
HDLF
EA
TLH
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
S
T
GAGSG
GQHA
VG
T
GVMGGM
IS
A
T
I
LAI
Y
FV
P
LF
F
V
LV
fig|358709.5.peg.2250
Escherichia coli 101-1 (16-1026/1037)
AI
L
L
C
L
T
G
TLA
I
FS
LPV
E
QYP
D
L
AP
P
N
V
R
V
T
A
N
YPGA
S
AQ
T
L
E
N
T
VT
Q
VIE
QN
M
TG
L
D
N
LM
Y
MSS
Q
S
SGT
G
QAS
V
TL
S
F
K
A
GT
D
PD
E
A
VQ
QVQ
NQ
LQ
S
A
MRK
LP
QAVQNQ
GV
TVR-KTGDT
---
N
I
LTI
A
FV
S
TDGSMDKQ
DI
A
D
Y
V
ASN
I
QDP
LS
RVN
GVG
D
I
DAY
G
SQY-SM
RI
W
LDP
AK
LN
SFQ
M
TAKD
V
TD
AI
ESQ
N
AQIAV
GQLGG
T
P
SVDKQALNAT
I
N
A
QSL
LQT
P
E
Q
F
RD
I
T
L
RVNQ
DG
SE
V
R
L
G
DVA
T
VE
M
G
A
E
KYDYL
S
RF
NGK
-
P
A
S
G
LG
V
K
L
AS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQY
FP
H
G
L
E
YKVA
Y
E
TT
SF
V
KA
SI
E
D
VVKT
L
L
EAI
A
LV
F
LV
M
YLFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
S
VL
Y
A
F
G
Y
S
V
N
T
LTM
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
E
GLT
P
RE
A
TR
K
SMG
QIQ
G
AL
VGIAMV
L
S
AVF
V
PM
A
F
FG
G
TT
G
A
IYR
Q
FSIT
IVA
AM
VL
SV
L
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWF
N
QM
F
NRNAER
----
Y
EKGVA
K
I
L
HRSLRW
I
V
I
Y
V
L
LLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQPLKVVE
Q
IE
K
YY
FTHEKDN
I
M
SVF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFNQIKEAR
V
I--
A
S
-
SPPA
I
SGL
G
SS
A
GFDME
L
QDHAGAGH
D
A
L
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
L
D
DSPQLQ
ID
I
D
QR
KA
Q
A
L
GV
AI
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
ML
P
DD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VG
EA
APGV
S
T
G
T
A
MDIMESLVKQ
L
-
-
P
N
G
FGLE
W
T
A
--
MS
YQ
ER
L
SGAQAPA
L
Y
A
-
I
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NEMN
Q
K-
----------
G
HDLF
EA
TLH
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
S
T
GAGSG
GQHA
VG
T
GVMGGM
IS
A
T
I
LAI
Y
FV
P
LF
F
V
LV
fig|562.375.peg.3443
Escherichia coli EC4100B (16-1026/1037)
AI
L
L
C
L
T
G
TLA
I
FS
LPV
E
QYP
D
L
AP
P
N
V
R
V
T
A
N
YPGA
S
AQ
T
L
E
N
T
VT
Q
VIE
QN
M
TG
L
D
N
LM
Y
MSS
Q
S
SGT
G
QAS
V
TL
S
F
K
A
GT
D
PD
E
A
VQ
QVQ
NQ
LQ
S
A
MRK
LP
QAVQNQ
GV
TVR-KTGDT
---
N
I
LTI
A
FV
S
TDGSMDKQ
DI
A
D
Y
V
ASN
I
QDP
LS
RVN
GVG
D
I
DAY
G
SQY-SM
RI
W
LDP
TK
LN
SFQ
M
TAKD
V
TD
AI
ESQ
N
AQIAV
GQLGG
T
P
SVDKQALNAT
I
N
A
QSL
LQT
P
E
Q
F
RD
I
T
L
RVNQ
DG
SE
V
R
L
G
DVA
T
VE
M
G
A
E
KYDYL
S
RF
NGK
-
P
A
S
G
LG
V
K
L
AS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQY
FP
H
G
L
E
YKVA
Y
E
TT
SF
V
KA
SI
E
D
VVKT
L
L
EAI
A
LV
F
LV
M
YLFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
S
VL
Y
A
F
G
Y
S
V
N
T
LTM
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
E
GLT
P
RE
A
TR
K
SMG
QIQ
G
AL
VGIAMV
L
S
AVF
V
PM
A
F
FG
G
TT
G
A
IYR
Q
FSIT
IVA
AM
VL
SV
L
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWF
N
QM
F
NRNAER
----
Y
EKGVA
K
I
L
HRSLRW
I
V
I
Y
V
L
LLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IE
K
YY
FTHEKDN
I
M
SVF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFNKIKEAR
V
I--
A
S
-
SPPA
I
SGL
G
SS
A
GFDME
L
QDHAGAGH
D
A
L
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
L
D
DSPQLQ
ID
I
D
QR
KA
Q
A
L
GV
D
I
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
ML
P
DD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VG
EA
APGV
S
T
G
T
A
MDIMESLVKQ
L
-
-
P
N
G
FGLE
W
T
A
--
MS
YQ
ER
L
SGAQAPA
L
Y
A
-
I
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NEMN
Q
K-
----------
G
HDLF
EA
TLH
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
S
T
GAGSG
GQHA
VG
T
GVMGGM
IS
A
T
I
LAI
Y
FV
P
LF
F
V
LV
fig|679205.4.peg.1336
Escherichia coli MS 124-1 (16-1026/1037)
AI
L
L
C
L
T
G
TLA
I
FS
LPV
E
QYP
D
L
AP
P
N
V
R
V
T
A
N
YPGA
S
AQ
T
L
E
N
T
VT
Q
VIE
QN
M
TG
L
D
N
LM
Y
MSS
Q
S
SGT
G
QAS
V
TL
S
F
K
A
GT
D
PD
E
A
VQ
QVQ
NQ
LQ
S
A
MRK
LP
QAVQNQ
GV
TVR-KTGDT
---
N
I
LTI
A
FV
S
TDGSMDKQ
DI
A
D
Y
V
ASN
I
QDP
LS
RVN
GVG
D
I
DAY
G
SQY-SM
RI
W
LDP
AK
LN
SFQ
M
TAKD
V
TD
AI
ESQ
N
AQIAV
GQLGG
T
P
SVDKQALNAT
I
N
A
QSL
LQT
P
E
Q
F
RD
I
T
L
RVNQ
DG
SE
V
R
L
G
DVA
T
VE
M
G
A
E
KYDYL
S
RF
NGK
-
P
A
S
G
LG
V
K
L
AS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQY
FP
H
G
L
E
YKVA
Y
E
TT
SF
V
KA
SI
E
D
VVKT
L
L
EAI
A
LV
F
LV
M
YLFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
S
VL
Y
A
F
G
Y
S
V
N
T
LTM
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
E
GLT
P
RE
A
TR
K
SMG
QIQ
G
AL
VGIAMV
L
S
AVF
V
PM
A
F
FG
G
TT
G
A
IYR
Q
FSIT
IVT
AM
VL
SV
L
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWF
N
QM
F
NRNAER
----
Y
EKGVA
K
I
L
HRSLRW
I
V
I
Y
V
L
LLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IE
K
YY
FTHEKDN
I
M
SVF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFNKIKEAR
V
I--
A
S
-
SPPA
I
SGL
G
SS
A
GFDME
L
QDHAGAGH
D
A
L
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
L
D
DSPQLQ
ID
I
D
QR
KA
Q
A
L
GV
D
I
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
ML
P
DD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VG
EA
APGV
S
T
G
T
A
MDIMESLVKQ
L
-
-
P
N
G
FGLE
W
T
A
--
MS
YQ
ER
L
SGAQAPA
L
Y
A
-
I
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NEMN
Q
K-
----------
G
HDLF
EA
TLH
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
S
T
GAGSG
GQHA
VG
T
GVMGGM
IS
A
T
I
LAI
Y
FV
P
LF
F
V
LV
fig|749533.3.peg.1535
Escherichia coli MS 84-1 (16-1026/1037)
AI
L
L
C
L
T
G
TLA
I
FS
LPV
E
QYP
D
L
AP
P
N
V
R
V
T
A
N
YPGA
S
AQ
T
L
E
N
T
VT
Q
VIE
QN
M
TG
L
D
N
LM
Y
MSS
Q
S
SGT
G
QAS
V
TL
S
F
K
A
GT
D
PD
E
A
VQ
QVQ
NQ
LQ
S
A
MRK
LP
QAVQNQ
GV
TVR-KTGDT
---
N
I
LTI
A
FV
S
TDGSMDKQ
DI
A
D
Y
V
ASN
I
QDP
LS
RVN
GVG
D
I
DAY
G
SQY-SM
RI
W
LDP
AK
LN
SFQ
M
TAKD
V
TD
AI
ESQ
N
AQIAV
GQLGG
T
P
SVDKQALNAT
I
N
A
QSL
LQT
P
E
Q
F
RD
I
T
L
RVNQ
DG
SE
V
R
L
G
DVA
T
VE
M
G
A
E
KYDYL
S
RF
NGK
-
P
A
S
G
LG
V
K
L
AS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQY
FP
H
G
L
E
YKVA
Y
E
TT
SF
V
KA
SI
E
D
VVKT
L
L
EAI
A
LV
F
LV
M
YLFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
S
VL
Y
A
F
G
Y
S
V
N
T
LTM
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
E
GLT
P
RE
A
TR
K
SMG
QIQ
G
AL
VGIAMV
L
S
AVF
V
PM
A
F
FG
G
TT
G
A
IYR
Q
FSIT
IVT
AM
VL
SV
L
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWF
N
QM
F
NRNAER
----
Y
EKGVA
K
I
L
HRSLRW
I
V
I
Y
V
L
LLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IE
K
YY
FTHEKDN
I
M
SVF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFNKIKEAR
V
I--
A
S
-
SPPA
I
SGL
G
SS
A
GFDME
L
QDHAGAGH
D
A
L
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
L
D
DSPQLQ
ID
I
D
QR
KA
Q
A
L
GV
D
I
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
ML
P
DD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VG
EA
APGV
S
T
G
T
A
MDIMESLVKQ
L
-
-
P
N
G
FGLE
W
T
A
--
MS
YQ
ER
L
SGAQAPA
L
Y
A
-
I
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NEMN
Q
K-
----------
G
HDLF
EA
TLH
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
S
T
GAGSG
GQHA
VG
T
GVMGGM
IS
A
T
I
LAI
Y
FV
P
LF
F
V
LV
fig|199310.1.peg.2922
Escherichia coli CFT073 (16-1026/1037)
AI
L
L
C
L
T
G
TLA
I
FS
LPV
E
QYP
D
L
AP
P
N
V
R
V
T
A
N
YPGA
S
AQ
T
L
E
N
T
VT
Q
VIE
QN
M
TG
L
D
N
LM
Y
MSS
Q
S
SGT
G
QAS
V
TL
S
F
K
A
GT
D
PD
E
A
VQ
QVQ
NQ
LQ
S
A
MRK
LP
QAVQNQ
GV
TVR-KTGDT
---
N
I
LTI
A
FV
S
TDGSMDKQ
DI
A
D
Y
V
ASN
I
QDP
LS
RVN
GVG
D
I
DAY
G
SQY-SM
RI
W
LDP
AK
LN
SFQ
M
TAKD
V
TD
AI
ESQ
N
AQIAV
GQLGG
T
P
SVDKQALNAT
I
N
A
QSL
LQT
P
E
Q
F
RD
I
T
L
RVNQ
DG
SE
V
R
L
G
DVA
T
VE
M
G
A
E
KYDYL
S
RF
NGK
-
P
A
S
G
LG
V
K
L
AS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQY
FP
H
G
L
E
YKVA
Y
E
TT
SF
V
KA
SI
E
D
VVKT
L
L
EAI
A
LV
F
LV
M
YLFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
S
VL
Y
A
F
G
Y
S
V
N
T
LTM
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
E
GLT
P
RE
A
TR
K
SMG
QIQ
G
AL
VGIAMV
L
S
AVF
V
PM
T
F
FG
G
TT
G
A
IYR
Q
FSIT
IVA
AM
VL
SV
L
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWF
N
QM
F
NRNSER
----
Y
EKGVA
K
I
L
HRSLRW
I
V
I
Y
V
L
LLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IE
K
YY
FTHEKDN
I
M
SVF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFNKIKEAR
V
I--
A
S
-
SPPA
I
SGL
G
SS
A
GFDME
L
QDHAGAGH
D
A
L
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
L
D
DSPQLQ
ID
I
D
QR
KA
Q
A
L
GV
AI
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
ML
P
DD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VG
EA
APGV
S
T
G
T
A
MDIMESLVKQ
L
-
-
P
N
G
FGLE
W
T
A
--
MS
YQ
ER
L
SGAQAPA
L
Y
A
-
I
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NEMN
Q
K-
----------
G
HDLF
EA
TLH
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
S
T
GAGSG
GQHA
VG
T
GVMGGM
IS
A
T
I
LAI
Y
FV
P
LF
F
V
LV
fig|199310.4.peg.2827
Escherichia coli CFT073 (16-1026/1037)
AI
L
L
C
L
T
G
TLA
I
FS
LPV
E
QYP
D
L
AP
P
N
V
R
V
T
A
N
YPGA
S
AQ
T
L
E
N
T
VT
Q
VIE
QN
M
TG
L
D
N
LM
Y
MSS
Q
S
SGT
G
QAS
V
TL
S
F
K
A
GT
D
PD
E
A
VQ
QVQ
NQ
LQ
S
A
MRK
LP
QAVQNQ
GV
TVR-KTGDT
---
N
I
LTI
A
FV
S
TDGSMDKQ
DI
A
D
Y
V
ASN
I
QDP
LS
RVN
GVG
D
I
DAY
G
SQY-SM
RI
W
LDP
AK
LN
SFQ
M
TAKD
V
TD
AI
ESQ
N
AQIAV
GQLGG
T
P
SVDKQALNAT
I
N
A
QSL
LQT
P
E
Q
F
RD
I
T
L
RVNQ
DG
SE
V
R
L
G
DVA
T
VE
M
G
A
E
KYDYL
S
RF
NGK
-
P
A
S
G
LG
V
K
L
AS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQY
FP
H
G
L
E
YKVA
Y
E
TT
SF
V
KA
SI
E
D
VVKT
L
L
EAI
A
LV
F
LV
M
YLFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
S
VL
Y
A
F
G
Y
S
V
N
T
LTM
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
E
GLT
P
RE
A
TR
K
SMG
QIQ
G
AL
VGIAMV
L
S
AVF
V
PM
T
F
FG
G
TT
G
A
IYR
Q
FSIT
IVA
AM
VL
SV
L
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWF
N
QM
F
NRNSER
----
Y
EKGVA
K
I
L
HRSLRW
I
V
I
Y
V
L
LLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IE
K
YY
FTHEKDN
I
M
SVF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFNKIKEAR
V
I--
A
S
-
SPPA
I
SGL
G
SS
A
GFDME
L
QDHAGAGH
D
A
L
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
L
D
DSPQLQ
ID
I
D
QR
KA
Q
A
L
GV
AI
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
ML
P
DD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VG
EA
APGV
S
T
G
T
A
MDIMESLVKQ
L
-
-
P
N
G
FGLE
W
T
A
--
MS
YQ
ER
L
SGAQAPA
L
Y
A
-
I
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NEMN
Q
K-
----------
G
HDLF
EA
TLH
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
S
T
GAGSG
GQHA
VG
T
GVMGGM
IS
A
T
I
LAI
Y
FV
P
LF
F
V
LV
fig|749528.3.peg.2359
Escherichia coli MS 45-1 (16-1026/1037)
AI
L
L
C
L
T
G
TLA
I
FS
LPV
E
QYP
D
L
AP
P
N
V
R
V
T
A
N
YPGA
S
AQ
T
L
E
N
T
VT
Q
VIE
QN
M
TG
L
D
N
LM
Y
MSS
Q
S
SGT
G
QAS
V
TL
S
F
K
A
GT
D
PD
E
A
VQ
QVQ
NQ
LQ
S
A
MRK
LP
QAVQNQ
GV
TVR-KTGDT
---
N
I
LTI
A
FV
S
TDGSMDKQ
DI
A
D
Y
V
ASN
I
QDP
LS
RVN
GVG
D
I
DAY
G
SQY-SM
RI
W
LDP
AK
LN
SFQ
M
TAKD
V
TD
AI
ESQ
N
AQIAV
GQLGG
T
P
SVDKQALNAT
I
N
A
QSL
LQT
P
E
Q
F
RD
I
T
L
RVNQ
DG
SE
V
R
L
G
DVA
T
VE
M
G
A
E
KYDYL
S
RF
NGK
-
P
A
S
G
LG
V
K
L
AS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQY
FP
H
G
L
E
YKVA
Y
E
TT
SF
V
KA
SI
E
D
VVKT
L
L
EAI
A
LV
F
LV
M
YLFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
S
VL
Y
A
F
G
Y
S
V
N
T
LTM
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
E
GLT
P
RE
A
TR
K
SMG
QIQ
G
AL
VGIAMV
L
S
AVF
V
PM
T
F
FG
G
TT
G
A
IYR
Q
FSIT
IVA
AM
VL
SV
L
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWF
N
QM
F
NRNSER
----
Y
EKGVA
K
I
L
HRSLRW
I
V
I
Y
V
L
LLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IE
K
YY
FTHEKDN
I
M
SVF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFNKIKEAR
V
I--
A
S
-
SPPA
I
SGL
G
SS
A
GFDME
L
QDHAGAGH
D
A
L
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
L
D
DSPQLQ
ID
I
D
QR
KA
Q
A
L
GV
AI
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
ML
P
DD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VG
EA
APGV
S
T
G
T
A
MDIMESLVKQ
L
-
-
P
N
G
FGLE
W
T
A
--
MS
YQ
ER
L
SGAQAPA
L
Y
A
-
I
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NEMN
Q
K-
----------
G
HDLF
EA
TLH
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
S
T
GAGSG
GQHA
VG
T
GVMGGM
IS
A
T
I
LAI
Y
FV
P
LF
F
V
LV
fig|562.371.peg.5329
Escherichia coli 1044A (16-1026/1037)
AI
L
L
C
L
T
G
TLA
I
FS
LPV
E
QYP
D
L
AP
P
N
V
R
V
T
A
N
YPGA
S
AQ
T
L
E
N
T
VT
Q
VIE
QN
M
TG
L
D
N
LM
Y
MSS
Q
S
SGT
G
QAS
V
TL
S
F
K
A
GT
D
PD
E
A
VQ
QVQ
NQ
LQ
S
A
MRK
LP
QAVQNQ
G
L
TVR-KTGDT
---
N
I
LTI
A
FV
S
TDGSMDKQ
DI
A
D
Y
V
ASN
I
QDP
LS
RVN
GVG
D
I
DAY
G
SQY-SM
RI
W
LDP
AK
LN
SFQ
M
TAKD
V
TD
AI
ESQ
N
AQIAV
GQLGG
T
P
SVDKQALNAT
I
N
A
QSL
LQT
P
E
Q
F
RD
I
T
L
RVNQ
DG
SE
V
R
L
G
DVA
T
A
E
M
G
A
E
KYDYL
S
RF
NGK
-
P
A
S
G
LG
V
K
L
AS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQY
FP
H
G
L
E
YKVA
Y
E
TT
SF
V
KA
SI
E
D
VVKT
L
L
EAI
A
LV
F
LV
M
YLFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
S
VL
Y
A
F
G
Y
S
V
N
T
LTM
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
E
GLT
P
RE
A
TR
K
SMG
QIQ
G
AL
VGIAMV
L
S
AVF
V
PM
A
F
FG
G
TT
G
A
IYR
Q
FSIT
IVA
AM
VL
SV
L
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWF
N
QM
F
NRNAER
----
Y
EKGVA
K
I
L
HRSLRW
I
V
I
Y
V
L
LLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IE
K
YY
FTHEKDN
I
M
SVF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFNQIKEAR
V
I--
A
S
-
SPPA
I
SGL
G
SS
A
GFDME
L
QDHAGAGH
D
A
L
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
L
D
DSPQLQ
ID
I
D
QR
KA
Q
A
L
GV
AI
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
ML
P
DD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VG
EA
APGV
S
T
G
T
A
MDIMESLVKQ
L
-
-
P
N
G
FGLE
W
T
A
--
MS
YQ
ER
L
SGAQAPA
L
Y
A
-
I
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NEMN
Q
K-
----------
G
HDLF
EA
TLH
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
S
T
GAGSG
GQHA
VG
T
GVMGGM
IS
A
T
I
LAI
Y
FV
P
LF
F
V
LV
fig|83334.1.peg.3329
Escherichia coli O157:H7 (16-1026/1037)
AI
L
L
C
L
T
G
TLA
I
FS
LPV
E
QYP
D
L
AP
P
N
V
R
V
T
A
N
YPGA
S
AQ
T
L
E
N
T
VT
Q
VIE
QN
M
TG
L
D
N
LM
Y
MSS
Q
S
SGT
G
QAS
V
TL
S
F
K
A
GT
D
PD
E
A
VQ
QVQ
NQ
LQ
S
A
MRK
LP
QAVQNQ
G
L
TVR-KTGDT
---
N
I
LTI
A
FV
S
TDGSMDKQ
DI
A
D
Y
V
ASN
I
QDP
LS
RVN
GVG
D
I
DAY
G
SQY-SM
RI
W
LDP
AK
LN
SFQ
M
TAKD
V
TD
AI
ESQ
N
AQIAV
GQLGG
T
P
SVDKQALNAT
I
N
A
QSL
LQT
P
E
Q
F
RD
I
T
L
RVNQ
DG
SE
V
R
L
G
DVA
T
A
E
M
G
A
E
KYDYL
S
RF
NGK
-
P
A
S
G
LG
V
K
L
AS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQY
FP
H
G
L
E
YKVA
Y
E
TT
SF
V
KA
SI
E
D
VVKT
L
L
EAI
A
LV
F
LV
M
YLFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
S
VL
Y
A
F
G
Y
S
V
N
T
LTM
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
E
GLT
P
RE
A
TR
K
SMG
QIQ
G
AL
VGIAMV
L
S
AVF
V
PM
A
F
FG
G
TT
G
A
IYR
Q
FSIT
IVA
AM
VL
SV
L
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWF
N
QM
F
NRNAER
----
Y
EKGVA
K
I
L
HRSLRW
I
V
I
Y
V
L
LLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IE
K
YY
FTHEKDN
I
M
SVF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFNQIKEAR
V
I--
A
S
-
SPPA
I
SGL
G
SS
A
GFDME
L
QDHAGAGH
D
A
L
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
L
D
DSPQLQ
ID
I
D
QR
KA
Q
A
L
GV
AI
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
ML
P
DD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VG
EA
APGV
S
T
G
T
A
MDIMESLVKQ
L
-
-
P
N
G
FGLE
W
T
A
--
MS
YQ
ER
L
SGAQAPA
L
Y
A
-
I
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NEMN
Q
K-
----------
G
HDLF
EA
TLH
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
S
T
GAGSG
GQHA
VG
T
GVMGGM
IS
A
T
I
LAI
Y
FV
P
LF
F
V
LV
fig|478006.5.peg.1579
Escherichia coli O157:H7 str. EC4501 (16-1026/1037)
AI
L
L
C
L
T
G
TLA
I
FS
LPV
E
QYP
D
L
AP
P
N
V
R
V
T
A
N
YPGA
S
AQ
T
L
E
N
T
VT
Q
VIE
QN
M
TG
L
D
N
LM
Y
MSS
Q
S
SGT
G
QAS
V
TL
S
F
K
A
GT
D
PD
E
A
VQ
QVQ
NQ
LQ
S
A
MRK
LP
QAVQNQ
G
L
TVR-KTGDT
---
N
I
LTI
A
FV
S
TDGSMDKQ
DI
A
D
Y
V
ASN
I
QDP
LS
RVN
GVG
D
I
DAY
G
SQY-SM
RI
W
LDP
AK
LN
SFQ
M
TAKD
V
TD
AI
ESQ
N
AQIAV
GQLGG
T
P
SVDKQALNAT
I
N
A
QSL
LQT
P
E
Q
F
RD
I
T
L
RVNQ
DG
SE
V
R
L
G
DVA
T
A
E
M
G
A
E
KYDYL
S
RF
NGK
-
P
A
S
G
LG
V
K
L
AS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQY
FP
H
G
L
E
YKVA
Y
E
TT
SF
V
KA
SI
E
D
VVKT
L
L
EAI
A
LV
F
LV
M
YLFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
S
VL
Y
A
F
G
Y
S
V
N
T
LTM
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
E
GLT
P
RE
A
TR
K
SMG
QIQ
G
AL
VGIAMV
L
S
AVF
V
PM
A
F
FG
G
TT
G
A
IYR
Q
FSIT
IVA
AM
VL
SV
L
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWF
N
QM
F
NRNAER
----
Y
EKGVA
K
I
L
HRSLRW
I
V
I
Y
V
L
LLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IE
K
YY
FTHEKDN
I
M
SVF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFNQIKEAR
V
I--
A
S
-
SPPA
I
SGL
G
SS
A
GFDME
L
QDHAGAGH
D
A
L
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
L
D
DSPQLQ
ID
I
D
QR
KA
Q
A
L
GV
AI
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
ML
P
DD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VG
EA
APGV
S
T
G
T
A
MDIMESLVKQ
L
-
-
P
N
G
FGLE
W
T
A
--
MS
YQ
ER
L
SGAQAPA
L
Y
A
-
I
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NEMN
Q
K-
----------
G
HDLF
EA
TLH
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
S
T
GAGSG
GQHA
VG
T
GVMGGM
IS
A
T
I
LAI
Y
FV
P
LF
F
V
LV
fig|386585.9.peg.3479
Escherichia coli O157:H7 str. Sakai (16-1026/1037)
AI
L
L
C
L
T
G
TLA
I
FS
LPV
E
QYP
D
L
AP
P
N
V
R
V
T
A
N
YPGA
S
AQ
T
L
E
N
T
VT
Q
VIE
QN
M
TG
L
D
N
LM
Y
MSS
Q
S
SGT
G
QAS
V
TL
S
F
K
A
GT
D
PD
E
A
VQ
QVQ
NQ
LQ
S
A
MRK
LP
QAVQNQ
G
L
TVR-KTGDT
---
N
I
LTI
A
FV
S
TDGSMDKQ
DI
A
D
Y
V
ASN
I
QDP
LS
RVN
GVG
D
I
DAY
G
SQY-SM
RI
W
LDP
AK
LN
SFQ
M
TAKD
V
TD
AI
ESQ
N
AQIAV
GQLGG
T
P
SVDKQALNAT
I
N
A
QSL
LQT
P
E
Q
F
RD
I
T
L
RVNQ
DG
SE
V
R
L
G
DVA
T
A
E
M
G
A
E
KYDYL
S
RF
NGK
-
P
A
S
G
LG
V
K
L
AS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQY
FP
H
G
L
E
YKVA
Y
E
TT
SF
V
KA
SI
E
D
VVKT
L
L
EAI
A
LV
F
LV
M
YLFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
S
VL
Y
A
F
G
Y
S
V
N
T
LTM
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
E
GLT
P
RE
A
TR
K
SMG
QIQ
G
AL
VGIAMV
L
S
AVF
V
PM
A
F
FG
G
TT
G
A
IYR
Q
FSIT
IVA
AM
VL
SV
L
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWF
N
QM
F
NRNAER
----
Y
EKGVA
K
I
L
HRSLRW
I
V
I
Y
V
L
LLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IE
K
YY
FTHEKDN
I
M
SVF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFNQIKEAR
V
I--
A
S
-
SPPA
I
SGL
G
SS
A
GFDME
L
QDHAGAGH
D
A
L
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
L
D
DSPQLQ
ID
I
D
QR
KA
Q
A
L
GV
AI
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
ML
P
DD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VG
EA
APGV
S
T
G
T
A
MDIMESLVKQ
L
-
-
P
N
G
FGLE
W
T
A
--
MS
YQ
ER
L
SGAQAPA
L
Y
A
-
I
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NEMN
Q
K-
----------
G
HDLF
EA
TLH
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
S
T
GAGSG
GQHA
VG
T
GVMGGM
IS
A
T
I
LAI
Y
FV
P
LF
F
V
LV
fig|502346.5.peg.3954
Escherichia coli O157:H7 str. TW14588 (16-1026/1037)
AI
L
L
C
L
T
G
TLA
I
FS
LPV
E
QYP
D
L
AP
P
N
V
R
V
T
A
N
YPGA
S
AQ
T
L
E
N
T
VT
Q
VIE
QN
M
TG
L
D
N
LM
Y
MSS
Q
S
SGT
G
QAS
V
TL
S
F
K
A
GT
D
PD
E
A
VQ
QVQ
NQ
LQ
S
A
MRK
LP
QAVQNQ
G
L
TVR-KTGDT
---
N
I
LTI
A
FV
S
TDGSMDKQ
DI
A
D
Y
V
ASN
I
QDP
LS
RVN
GVG
D
I
DAY
G
SQY-SM
RI
W
LDP
AK
LN
SFQ
M
TAKD
V
TD
AI
ESQ
N
AQIAV
GQLGG
T
P
SVDKQALNAT
I
N
A
QSL
LQT
P
E
Q
F
RD
I
T
L
RVNQ
DG
SE
V
R
L
G
DVA
T
A
E
M
G
A
E
KYDYL
S
RF
NGK
-
P
A
S
G
LG
V
K
L
AS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQY
FP
H
G
L
E
YKVA
Y
E
TT
SF
V
KA
SI
E
D
VVKT
L
L
EAI
A
LV
F
LV
M
YLFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
S
VL
Y
A
F
G
Y
S
V
N
T
LTM
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
E
GLT
P
RE
A
TR
K
SMG
QIQ
G
AL
VGIAMV
L
S
AVF
V
PM
A
F
FG
G
TT
G
A
IYR
Q
FSIT
IVA
AM
VL
SV
L
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWF
N
QM
F
NRNAER
----
Y
EKGVA
K
I
L
HRSLRW
I
V
I
Y
V
L
LLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IE
K
YY
FTHEKDN
I
M
SVF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFNQIKEAR
V
I--
A
S
-
SPPA
I
SGL
G
SS
A
GFDME
L
QDHAGAGH
D
A
L
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
L
D
DSPQLQ
ID
I
D
QR
KA
Q
A
L
GV
AI
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
ML
P
DD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VG
EA
APGV
S
T
G
T
A
MDIMESLVKQ
L
-
-
P
N
G
FGLE
W
T
A
--
MS
YQ
ER
L
SGAQAPA
L
Y
A
-
I
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NEMN
Q
K-
----------
G
HDLF
EA
TLH
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
S
T
GAGSG
GQHA
VG
T
GVMGGM
IS
A
T
I
LAI
Y
FV
P
LF
F
V
LV
fig|585397.7.peg.2914
Escherichia coli ED1a (16-1026/1037)
AI
L
L
C
L
T
G
TLA
I
FS
LPV
E
QYP
D
L
AP
P
N
V
R
V
T
A
N
YPGA
S
AQ
T
L
E
N
T
VT
Q
VIE
QN
M
TG
L
D
N
LM
Y
MSS
Q
S
SGT
G
QAS
V
TL
S
F
K
A
GT
D
PD
E
A
VQ
QVQ
NQ
LQ
S
A
MRK
LP
QAVQNQ
GV
TVR-KTGDT
---
N
I
LTI
A
FV
S
TDGSMDKQ
DI
A
D
Y
V
ASN
I
QDP
LS
RVN
GVG
D
I
DAY
G
SQY-SM
RI
W
LDP
AK
LN
SFQ
M
TAKD
V
TD
AI
ESQ
N
AQIAV
GQLGG
T
P
SVDKQALNAT
I
N
A
QSL
LQT
P
E
Q
F
RD
I
T
L
RVNQ
DG
SE
V
R
L
G
DVA
T
VE
M
G
A
E
KYDYL
S
RF
NGK
-
P
A
S
G
LG
V
K
L
AS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQY
FP
H
G
L
E
YKVA
Y
E
TT
SF
V
KA
SI
E
D
VVKT
L
L
EAI
A
LV
F
LV
M
YLFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
S
VL
Y
A
F
G
Y
S
V
N
T
LTM
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
E
GLT
P
RE
A
TR
K
SMG
QIQ
G
AL
VGIAMV
L
S
AVF
V
PM
A
F
FG
G
TT
G
A
IYR
Q
FSIT
IVA
AM
VL
SV
L
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWF
N
QM
F
NRNSER
----
Y
EKGVA
K
I
L
HRSLRW
I
V
I
Y
V
L
LLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IE
K
YY
FTHEKDN
I
M
SVF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFNKIKEAR
V
I--
A
S
-
SPPA
I
SGL
G
SS
A
GFDME
L
QDHAGAGH
D
A
L
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
L
D
DSPQLQ
ID
I
D
QR
KA
Q
A
L
GV
AI
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
ML
P
DD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VG
EA
APGV
S
T
G
T
A
MDIMESLVKQ
L
-
-
P
N
G
FGLE
W
T
A
--
MS
YQ
ER
L
SGAQAPA
L
Y
A
-
I
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NEMN
Q
K-
----------
G
HDLF
EA
TLH
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
S
T
GAGSG
GQHA
VG
T
GVMGGM
IS
A
T
I
LAI
Y
FV
P
LF
F
V
LV
fig|585397.9.peg.2911
Escherichia coli ED1a (16-1026/1037)
AI
L
L
C
L
T
G
TLA
I
FS
LPV
E
QYP
D
L
AP
P
N
V
R
V
T
A
N
YPGA
S
AQ
T
L
E
N
T
VT
Q
VIE
QN
M
TG
L
D
N
LM
Y
MSS
Q
S
SGT
G
QAS
V
TL
S
F
K
A
GT
D
PD
E
A
VQ
QVQ
NQ
LQ
S
A
MRK
LP
QAVQNQ
GV
TVR-KTGDT
---
N
I
LTI
A
FV
S
TDGSMDKQ
DI
A
D
Y
V
ASN
I
QDP
LS
RVN
GVG
D
I
DAY
G
SQY-SM
RI
W
LDP
AK
LN
SFQ
M
TAKD
V
TD
AI
ESQ
N
AQIAV
GQLGG
T
P
SVDKQALNAT
I
N
A
QSL
LQT
P
E
Q
F
RD
I
T
L
RVNQ
DG
SE
V
R
L
G
DVA
T
VE
M
G
A
E
KYDYL
S
RF
NGK
-
P
A
S
G
LG
V
K
L
AS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQY
FP
H
G
L
E
YKVA
Y
E
TT
SF
V
KA
SI
E
D
VVKT
L
L
EAI
A
LV
F
LV
M
YLFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
S
VL
Y
A
F
G
Y
S
V
N
T
LTM
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
E
GLT
P
RE
A
TR
K
SMG
QIQ
G
AL
VGIAMV
L
S
AVF
V
PM
A
F
FG
G
TT
G
A
IYR
Q
FSIT
IVA
AM
VL
SV
L
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWF
N
QM
F
NRNSER
----
Y
EKGVA
K
I
L
HRSLRW
I
V
I
Y
V
L
LLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IE
K
YY
FTHEKDN
I
M
SVF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFNKIKEAR
V
I--
A
S
-
SPPA
I
SGL
G
SS
A
GFDME
L
QDHAGAGH
D
A
L
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
L
D
DSPQLQ
ID
I
D
QR
KA
Q
A
L
GV
AI
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
ML
P
DD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VG
EA
APGV
S
T
G
T
A
MDIMESLVKQ
L
-
-
P
N
G
FGLE
W
T
A
--
MS
YQ
ER
L
SGAQAPA
L
Y
A
-
I
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NEMN
Q
K-
----------
G
HDLF
EA
TLH
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
S
T
GAGSG
GQHA
VG
T
GVMGGM
IS
A
T
I
LAI
Y
FV
P
LF
F
V
LV
fig|685038.3.peg.2506
Escherichia coli O83:H1 str. NRG 857C (16-1026/1037)
AI
L
L
C
L
T
G
TLA
I
FS
LPV
E
QYP
D
L
AP
P
N
V
R
V
T
A
N
YPGA
S
AQ
T
L
E
N
T
VT
Q
VIE
QN
M
TG
L
D
N
LM
Y
MSS
Q
S
SGT
G
QAS
V
TL
S
F
K
A
GT
D
PD
E
A
VQ
QVQ
NQ
LQ
S
A
MRK
LP
QAVQNQ
GV
TVR-KTGDT
---
N
I
LTI
A
FV
S
TDGSMDKQ
DI
A
D
Y
V
ASN
I
QDP
LS
RVN
GVG
D
I
DAY
G
SQY-SM
RI
W
LDP
AK
LN
SFQ
M
TAKD
V
TD
AI
ESQ
N
AQIAV
GQLGG
T
P
SVDKQALNAT
I
N
A
QSL
LQT
P
E
Q
F
RD
I
T
L
RVNQ
DG
SE
V
R
L
G
DVA
T
VE
M
G
A
E
KYDYL
S
RF
NGK
-
P
A
S
G
LG
V
K
L
AS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQY
FP
H
G
L
E
YKVA
Y
E
TT
SF
V
KA
SI
E
D
VVKT
L
L
EAI
A
LV
F
LV
M
YLFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
S
VL
Y
A
F
G
Y
S
V
N
T
LTM
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
E
GLT
P
RE
A
TR
K
SMG
QIQ
G
AL
VGIAMV
L
S
AVF
V
PM
A
F
FG
G
TT
G
A
IYR
Q
FSIT
IVA
AM
VL
SV
L
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWF
N
QM
F
NRNSER
----
Y
EKGVA
K
I
L
HRSLRW
I
V
I
Y
V
L
LLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IE
K
YY
FTHEKDN
I
M
SVF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFNKIKEAR
V
I--
A
S
-
SPPA
I
SGL
G
SS
A
GFDME
L
QDHAGAGH
D
A
L
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
L
D
DSPQLQ
ID
I
D
QR
KA
Q
A
L
GV
AI
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
ML
P
DD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VG
EA
APGV
S
T
G
T
A
MDIMESLVKQ
L
-
-
P
N
G
FGLE
W
T
A
--
MS
YQ
ER
L
SGAQAPA
L
Y
A
-
I
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NEMN
Q
K-
----------
G
HDLF
EA
TLH
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
S
T
GAGSG
GQHA
VG
T
GVMGGM
IS
A
T
I
LAI
Y
FV
P
LF
F
V
LV
fig|340184.3.peg.2721
Escherichia coli B7A (16-1026/1037)
AI
L
L
C
L
T
G
TLA
I
FS
LPV
E
QYP
D
L
AP
P
N
V
R
V
T
A
N
YPGA
S
AQ
T
L
E
N
T
VT
Q
VIE
QN
M
TG
L
D
N
LM
Y
MSS
Q
S
SGT
G
QAS
V
TL
S
F
K
A
GT
D
PD
E
A
VQ
QVQ
NQ
LQ
S
A
MRK
LP
QAVQNQ
GV
TVR-KTGDT
---
N
I
LTI
A
FV
S
TDGSMDKQ
DI
A
D
Y
V
ASN
I
QDP
LS
RVN
GVG
D
I
DAY
G
SQY-SM
RI
W
LDP
AK
LN
SFQ
M
TAKD
V
TD
AI
ESQ
N
AQIAV
GQLGG
T
P
SVDKQALNAT
I
N
A
QSL
LQT
P
E
Q
F
RD
I
T
L
RVNQ
DG
SE
V
R
L
G
DVA
T
VE
M
G
A
E
KYDYL
S
RF
NGK
-
P
A
S
G
LG
V
K
L
AS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQY
FP
H
G
L
E
YKVA
Y
E
TT
SF
V
KA
SI
E
D
VVKT
L
L
EAI
A
LV
F
LV
M
YLFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
S
VL
Y
A
F
G
Y
S
V
N
T
LTM
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
E
GLT
P
RE
A
TR
K
SMG
QIQ
G
AL
VGIAMV
L
S
AVF
V
PM
A
F
FG
G
TT
G
A
IYR
Q
FSIT
IVA
AM
VL
SV
L
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWF
N
QM
F
NRNAER
----
Y
EKGVA
K
I
L
HRSLRW
I
V
I
Y
V
L
LLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IE
K
YY
FTHEKDN
I
M
SVF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFNKIKEAR
V
I--
A
S
-
SPPA
I
SGL
G
SS
A
GFDME
L
QDHAGAGH
D
A
L
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
L
D
DSPQLQ
ID
I
D
QR
KA
Q
A
L
GV
D
I
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
ML
P
DD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VG
EA
APGV
S
T
G
T
A
MDIMESLVKQ
L
-
-
P
N
G
FGLE
W
T
A
--
MS
YQ
ER
L
SGAQAPA
L
Y
A
-
I
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NEMN
Q
K-
----------
G
HDLF
EA
TLH
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
S
T
GAGSG
GQHA
VG
T
GVMGGM
IS
A
T
I
LAI
Y
FV
P
LF
F
V
LV
fig|340184.6.peg.2848
Escherichia coli B7A (16-1026/1037)
AI
L
L
C
L
T
G
TLA
I
FS
LPV
E
QYP
D
L
AP
P
N
V
R
V
T
A
N
YPGA
S
AQ
T
L
E
N
T
VT
Q
VIE
QN
M
TG
L
D
N
LM
Y
MSS
Q
S
SGT
G
QAS
V
TL
S
F
K
A
GT
D
PD
E
A
VQ
QVQ
NQ
LQ
S
A
MRK
LP
QAVQNQ
GV
TVR-KTGDT
---
N
I
LTI
A
FV
S
TDGSMDKQ
DI
A
D
Y
V
ASN
I
QDP
LS
RVN
GVG
D
I
DAY
G
SQY-SM
RI
W
LDP
AK
LN
SFQ
M
TAKD
V
TD
AI
ESQ
N
AQIAV
GQLGG
T
P
SVDKQALNAT
I
N
A
QSL
LQT
P
E
Q
F
RD
I
T
L
RVNQ
DG
SE
V
R
L
G
DVA
T
VE
M
G
A
E
KYDYL
S
RF
NGK
-
P
A
S
G
LG
V
K
L
AS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQY
FP
H
G
L
E
YKVA
Y
E
TT
SF
V
KA
SI
E
D
VVKT
L
L
EAI
A
LV
F
LV
M
YLFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
S
VL
Y
A
F
G
Y
S
V
N
T
LTM
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
E
GLT
P
RE
A
TR
K
SMG
QIQ
G
AL
VGIAMV
L
S
AVF
V
PM
A
F
FG
G
TT
G
A
IYR
Q
FSIT
IVA
AM
VL
SV
L
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWF
N
QM
F
NRNAER
----
Y
EKGVA
K
I
L
HRSLRW
I
V
I
Y
V
L
LLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IE
K
YY
FTHEKDN
I
M
SVF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFNKIKEAR
V
I--
A
S
-
SPPA
I
SGL
G
SS
A
GFDME
L
QDHAGAGH
D
A
L
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
L
D
DSPQLQ
ID
I
D
QR
KA
Q
A
L
GV
D
I
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
ML
P
DD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VG
EA
APGV
S
T
G
T
A
MDIMESLVKQ
L
-
-
P
N
G
FGLE
W
T
A
--
MS
YQ
ER
L
SGAQAPA
L
Y
A
-
I
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NEMN
Q
K-
----------
G
HDLF
EA
TLH
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
S
T
GAGSG
GQHA
VG
T
GVMGGM
IS
A
T
I
LAI
Y
FV
P
LF
F
V
LV
fig|656408.3.peg.2751
Escherichia coli H591 (16-1026/1037)
AI
L
L
C
L
T
G
TLA
I
FS
LPV
E
QYP
D
L
AP
P
N
V
R
V
T
A
N
YPGA
S
AQ
T
L
E
N
T
VT
Q
VIE
QN
M
TG
L
D
N
LM
Y
MSS
Q
S
SGT
G
QAS
V
TL
S
F
K
A
GT
D
PD
E
A
VQ
QVQ
NQ
LQ
S
A
MRK
LP
QAVQNQ
GV
TVR-KTGDT
---
N
I
LTI
A
FV
S
TDGSMDKQ
DI
A
D
Y
V
ASN
I
QDP
LS
RVN
GVG
D
I
DAY
G
SQY-SM
RI
W
LDP
AK
LN
SFQ
M
TAKD
V
TD
AI
ESQ
N
AQIAV
GQLGG
T
P
SVDKQALNAT
I
N
A
QSL
LQT
P
E
Q
F
RD
I
T
L
RVNQ
DG
SE
V
R
L
G
DVA
T
VE
M
G
A
E
KYDYL
S
RF
NGK
-
P
A
S
G
LG
V
K
L
AS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQY
FP
H
G
L
E
YKVA
Y
E
TT
SF
V
KA
SI
E
D
VVKT
L
L
EAI
A
LV
F
LV
M
YLFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
S
VL
Y
A
F
G
Y
S
V
N
T
LTM
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
E
GLT
P
RE
A
TR
K
SMG
QIQ
G
AL
VGIAMV
L
S
AVF
V
PM
A
F
FG
G
TT
G
A
IYR
Q
FSIT
IVA
AM
VL
SV
L
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWF
N
QM
F
NRNAER
----
Y
EKGVA
K
I
L
HRSLRW
I
V
I
Y
V
L
LLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IE
K
YY
FTHEKDN
I
M
SVF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFNKIKEAR
V
I--
A
S
-
SPPA
I
SGL
G
SS
A
GFDME
L
QDHAGAGH
D
A
L
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
L
D
DSPQLQ
ID
I
D
QR
KA
Q
A
L
GV
D
I
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
ML
P
DD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VG
EA
APGV
S
T
G
T
A
MDIMESLVKQ
L
-
-
P
N
G
FGLE
W
T
A
--
MS
YQ
ER
L
SGAQAPA
L
Y
A
-
I
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NEMN
Q
K-
----------
G
HDLF
EA
TLH
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
S
T
GAGSG
GQHA
VG
T
GVMGGM
IS
A
T
I
LAI
Y
FV
P
LF
F
V
LV
fig|595495.4.peg.2507
Escherichia coli KO11 (16-1026/1037)
AI
L
L
C
L
T
G
TLA
I
FS
LPV
E
QYP
D
L
AP
P
N
V
R
V
T
A
N
YPGA
S
AQ
T
L
E
N
T
VT
Q
VIE
QN
M
TG
L
D
N
LM
Y
MSS
Q
S
SGT
G
QAS
V
TL
S
F
K
A
GT
D
PD
E
A
VQ
QVQ
NQ
LQ
S
A
MRK
LP
QAVQNQ
GV
TVR-KTGDT
---
N
I
LTI
A
FV
S
TDGSMDKQ
DI
A
D
Y
V
ASN
I
QDP
LS
RVN
GVG
D
I
DAY
G
SQY-SM
RI
W
LDP
AK
LN
SFQ
M
TAKD
V
TD
AI
ESQ
N
AQIAV
GQLGG
T
P
SVDKQALNAT
I
N
A
QSL
LQT
P
E
Q
F
RD
I
T
L
RVNQ
DG
SE
V
R
L
G
DVA
T
VE
M
G
A
E
KYDYL
S
RF
NGK
-
P
A
S
G
LG
V
K
L
AS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQY
FP
H
G
L
E
YKVA
Y
E
TT
SF
V
KA
SI
E
D
VVKT
L
L
EAI
A
LV
F
LV
M
YLFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
S
VL
Y
A
F
G
Y
S
V
N
T
LTM
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
E
GLT
P
RE
A
TR
K
SMG
QIQ
G
AL
VGIAMV
L
S
AVF
V
PM
A
F
FG
G
TT
G
A
IYR
Q
FSIT
IVA
AM
VL
SV
L
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWF
N
QM
F
NRNAER
----
Y
EKGVA
K
I
L
HRSLRW
I
V
I
Y
V
L
LLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IE
K
YY
FTHEKDN
I
M
SVF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFNKIKEAR
V
I--
A
S
-
SPPA
I
SGL
G
SS
A
GFDME
L
QDHAGAGH
D
A
L
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
L
D
DSPQLQ
ID
I
D
QR
KA
Q
A
L
GV
D
I
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
ML
P
DD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VG
EA
APGV
S
T
G
T
A
MDIMESLVKQ
L
-
-
P
N
G
FGLE
W
T
A
--
MS
YQ
ER
L
SGAQAPA
L
Y
A
-
I
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NEMN
Q
K-
----------
G
HDLF
EA
TLH
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
S
T
GAGSG
GQHA
VG
T
GVMGGM
IS
A
T
I
LAI
Y
FV
P
LF
F
V
LV
fig|679206.4.peg.651
Escherichia coli MS 119-7 (16-1026/1037)
AI
L
L
C
L
T
G
TLA
I
FS
LPV
E
QYP
D
L
AP
P
N
V
R
V
T
A
N
YPGA
S
AQ
T
L
E
N
T
VT
Q
VIE
QN
M
TG
L
D
N
LM
Y
MSS
Q
S
SGT
G
QAS
V
TL
S
F
K
A
GT
D
PD
E
A
VQ
QVQ
NQ
LQ
S
A
MRK
LP
QAVQNQ
GV
TVR-KTGDT
---
N
I
LTI
A
FV
S
TDGSMDKQ
DI
A
D
Y
V
ASN
I
QDP
LS
RVN
GVG
D
I
DAY
G
SQY-SM
RI
W
LDP
AK
LN
SFQ
M
TAKD
V
TD
AI
ESQ
N
AQIAV
GQLGG
T
P
SVDKQALNAT
I
N
A
QSL
LQT
P
E
Q
F
RD
I
T
L
RVNQ
DG
SE
V
R
L
G
DVA
T
VE
M
G
A
E
KYDYL
S
RF
NGK
-
P
A
S
G
LG
V
K
L
AS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQY
FP
H
G
L
E
YKVA
Y
E
TT
SF
V
KA
SI
E
D
VVKT
L
L
EAI
A
LV
F
LV
M
YLFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
S
VL
Y
A
F
G
Y
S
V
N
T
LTM
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
E
GLT
P
RE
A
TR
K
SMG
QIQ
G
AL
VGIAMV
L
S
AVF
V
PM
A
F
FG
G
TT
G
A
IYR
Q
FSIT
IVA
AM
VL
SV
L
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWF
N
QM
F
NRNAER
----
Y
EKGVA
K
I
L
HRSLRW
I
V
I
Y
V
L
LLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IE
K
YY
FTHEKDN
I
M
SVF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFNKIKEAR
V
I--
A
S
-
SPPA
I
SGL
G
SS
A
GFDME
L
QDHAGAGH
D
A
L
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
L
D
DSPQLQ
ID
I
D
QR
KA
Q
A
L
GV
D
I
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
ML
P
DD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VG
EA
APGV
S
T
G
T
A
MDIMESLVKQ
L
-
-
P
N
G
FGLE
W
T
A
--
MS
YQ
ER
L
SGAQAPA
L
Y
A
-
I
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NEMN
Q
K-
----------
G
HDLF
EA
TLH
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
S
T
GAGSG
GQHA
VG
T
GVMGGM
IS
A
T
I
LAI
Y
FV
P
LF
F
V
LV
fig|749532.3.peg.3273
Escherichia coli MS 78-1 (16-1026/1037)
AI
L
L
C
L
T
G
TLA
I
FS
LPV
E
QYP
D
L
AP
P
N
V
R
V
T
A
N
YPGA
S
AQ
T
L
E
N
T
VT
Q
VIE
QN
M
TG
L
D
N
LM
Y
MSS
Q
S
SGT
G
QAS
V
TL
S
F
K
A
GT
D
PD
E
A
VQ
QVQ
NQ
LQ
S
A
MRK
LP
QAVQNQ
GV
TVR-KTGDT
---
N
I
LTI
A
FV
S
TDGSMDKQ
DI
A
D
Y
V
ASN
I
QDP
LS
RVN
GVG
D
I
DAY
G
SQY-SM
RI
W
LDP
AK
LN
SFQ
M
TAKD
V
TD
AI
ESQ
N
AQIAV
GQLGG
T
P
SVDKQALNAT
I
N
A
QSL
LQT
P
E
Q
F
RD
I
T
L
RVNQ
DG
SE
V
R
L
G
DVA
T
VE
M
G
A
E
KYDYL
S
RF
NGK
-
P
A
S
G
LG
V
K
L
AS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQY
FP
H
G
L
E
YKVA
Y
E
TT
SF
V
KA
SI
E
D
VVKT
L
L
EAI
A
LV
F
LV
M
YLFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
S
VL
Y
A
F
G
Y
S
V
N
T
LTM
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
E
GLT
P
RE
A
TR
K
SMG
QIQ
G
AL
VGIAMV
L
S
AVF
V
PM
A
F
FG
G
TT
G
A
IYR
Q
FSIT
IVA
AM
VL
SV
L
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWF
N
QM
F
NRNAER
----
Y
EKGVA
K
I
L
HRSLRW
I
V
I
Y
V
L
LLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IE
K
YY
FTHEKDN
I
M
SVF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFNKIKEAR
V
I--
A
S
-
SPPA
I
SGL
G
SS
A
GFDME
L
QDHAGAGH
D
A
L
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
L
D
DSPQLQ
ID
I
D
QR
KA
Q
A
L
GV
D
I
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
ML
P
DD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VG
EA
APGV
S
T
G
T
A
MDIMESLVKQ
L
-
-
P
N
G
FGLE
W
T
A
--
MS
YQ
ER
L
SGAQAPA
L
Y
A
-
I
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NEMN
Q
K-
----------
G
HDLF
EA
TLH
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
S
T
GAGSG
GQHA
VG
T
GVMGGM
IS
A
T
I
LAI
Y
FV
P
LF
F
V
LV
fig|409438.11.peg.2918
Escherichia coli SE11 (16-1026/1037)
AI
L
L
C
L
T
G
TLA
I
FS
LPV
E
QYP
D
L
AP
P
N
V
R
V
T
A
N
YPGA
S
AQ
T
L
E
N
T
VT
Q
VIE
QN
M
TG
L
D
N
LM
Y
MSS
Q
S
SGT
G
QAS
V
TL
S
F
K
A
GT
D
PD
E
A
VQ
QVQ
NQ
LQ
S
A
MRK
LP
QAVQNQ
GV
TVR-KTGDT
---
N
I
LTI
A
FV
S
TDGSMDKQ
DI
A
D
Y
V
ASN
I
QDP
LS
RVN
GVG
D
I
DAY
G
SQY-SM
RI
W
LDP
AK
LN
SFQ
M
TAKD
V
TD
AI
ESQ
N
AQIAV
GQLGG
T
P
SVDKQALNAT
I
N
A
QSL
LQT
P
E
Q
F
RD
I
T
L
RVNQ
DG
SE
V
R
L
G
DVA
T
VE
M
G
A
E
KYDYL
S
RF
NGK
-
P
A
S
G
LG
V
K
L
AS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQY
FP
H
G
L
E
YKVA
Y
E
TT
SF
V
KA
SI
E
D
VVKT
L
L
EAI
A
LV
F
LV
M
YLFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
S
VL
Y
A
F
G
Y
S
V
N
T
LTM
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
E
GLT
P
RE
A
TR
K
SMG
QIQ
G
AL
VGIAMV
L
S
AVF
V
PM
A
F
FG
G
TT
G
A
IYR
Q
FSIT
IVA
AM
VL
SV
L
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWF
N
QM
F
NRNAER
----
Y
EKGVA
K
I
L
HRSLRW
I
V
I
Y
V
L
LLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IE
K
YY
FTHEKDN
I
M
SVF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFNKIKEAR
V
I--
A
S
-
SPPA
I
SGL
G
SS
A
GFDME
L
QDHAGAGH
D
A
L
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
L
D
DSPQLQ
ID
I
D
QR
KA
Q
A
L
GV
D
I
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
ML
P
DD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VG
EA
APGV
S
T
G
T
A
MDIMESLVKQ
L
-
-
P
N
G
FGLE
W
T
A
--
MS
YQ
ER
L
SGAQAPA
L
Y
A
-
I
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NEMN
Q
K-
----------
G
HDLF
EA
TLH
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
S
T
GAGSG
GQHA
VG
T
GVMGGM
IS
A
T
I
LAI
Y
FV
P
LF
F
V
LV
fig|566546.3.peg.2692
Escherichia coli W (16-1026/1037)
AI
L
L
C
L
T
G
TLA
I
FS
LPV
E
QYP
D
L
AP
P
N
V
R
V
T
A
N
YPGA
S
AQ
T
L
E
N
T
VT
Q
VIE
QN
M
TG
L
D
N
LM
Y
MSS
Q
S
SGT
G
QAS
V
TL
S
F
K
A
GT
D
PD
E
A
VQ
QVQ
NQ
LQ
S
A
MRK
LP
QAVQNQ
GV
TVR-KTGDT
---
N
I
LTI
A
FV
S
TDGSMDKQ
DI
A
D
Y
V
ASN
I
QDP
LS
RVN
GVG
D
I
DAY
G
SQY-SM
RI
W
LDP
AK
LN
SFQ
M
TAKD
V
TD
AI
ESQ
N
AQIAV
GQLGG
T
P
SVDKQALNAT
I
N
A
QSL
LQT
P
E
Q
F
RD
I
T
L
RVNQ
DG
SE
V
R
L
G
DVA
T
VE
M
G
A
E
KYDYL
S
RF
NGK
-
P
A
S
G
LG
V
K
L
AS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQY
FP
H
G
L
E
YKVA
Y
E
TT
SF
V
KA
SI
E
D
VVKT
L
L
EAI
A
LV
F
LV
M
YLFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
S
VL
Y
A
F
G
Y
S
V
N
T
LTM
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
E
GLT
P
RE
A
TR
K
SMG
QIQ
G
AL
VGIAMV
L
S
AVF
V
PM
A
F
FG
G
TT
G
A
IYR
Q
FSIT
IVA
AM
VL
SV
L
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWF
N
QM
F
NRNAER
----
Y
EKGVA
K
I
L
HRSLRW
I
V
I
Y
V
L
LLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IE
K
YY
FTHEKDN
I
M
SVF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFNKIKEAR
V
I--
A
S
-
SPPA
I
SGL
G
SS
A
GFDME
L
QDHAGAGH
D
A
L
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
L
D
DSPQLQ
ID
I
D
QR
KA
Q
A
L
GV
D
I
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
ML
P
DD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VG
EA
APGV
S
T
G
T
A
MDIMESLVKQ
L
-
-
P
N
G
FGLE
W
T
A
--
MS
YQ
ER
L
SGAQAPA
L
Y
A
-
I
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NEMN
Q
K-
----------
G
HDLF
EA
TLH
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
S
T
GAGSG
GQHA
VG
T
GVMGGM
IS
A
T
I
LAI
Y
FV
P
LF
F
V
LV
fig|566546.4.peg.2662
Escherichia coli W (16-1026/1037)
AI
L
L
C
L
T
G
TLA
I
FS
LPV
E
QYP
D
L
AP
P
N
V
R
V
T
A
N
YPGA
S
AQ
T
L
E
N
T
VT
Q
VIE
QN
M
TG
L
D
N
LM
Y
MSS
Q
S
SGT
G
QAS
V
TL
S
F
K
A
GT
D
PD
E
A
VQ
QVQ
NQ
LQ
S
A
MRK
LP
QAVQNQ
GV
TVR-KTGDT
---
N
I
LTI
A
FV
S
TDGSMDKQ
DI
A
D
Y
V
ASN
I
QDP
LS
RVN
GVG
D
I
DAY
G
SQY-SM
RI
W
LDP
AK
LN
SFQ
M
TAKD
V
TD
AI
ESQ
N
AQIAV
GQLGG
T
P
SVDKQALNAT
I
N
A
QSL
LQT
P
E
Q
F
RD
I
T
L
RVNQ
DG
SE
V
R
L
G
DVA
T
VE
M
G
A
E
KYDYL
S
RF
NGK
-
P
A
S
G
LG
V
K
L
AS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQY
FP
H
G
L
E
YKVA
Y
E
TT
SF
V
KA
SI
E
D
VVKT
L
L
EAI
A
LV
F
LV
M
YLFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
S
VL
Y
A
F
G
Y
S
V
N
T
LTM
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
E
GLT
P
RE
A
TR
K
SMG
QIQ
G
AL
VGIAMV
L
S
AVF
V
PM
A
F
FG
G
TT
G
A
IYR
Q
FSIT
IVA
AM
VL
SV
L
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWF
N
QM
F
NRNAER
----
Y
EKGVA
K
I
L
HRSLRW
I
V
I
Y
V
L
LLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IE
K
YY
FTHEKDN
I
M
SVF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFNKIKEAR
V
I--
A
S
-
SPPA
I
SGL
G
SS
A
GFDME
L
QDHAGAGH
D
A
L
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
L
D
DSPQLQ
ID
I
D
QR
KA
Q
A
L
GV
D
I
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
ML
P
DD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VG
EA
APGV
S
T
G
T
A
MDIMESLVKQ
L
-
-
P
N
G
FGLE
W
T
A
--
MS
YQ
ER
L
SGAQAPA
L
Y
A
-
I
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NEMN
Q
K-
----------
G
HDLF
EA
TLH
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
S
T
GAGSG
GQHA
VG
T
GVMGGM
IS
A
T
I
LAI
Y
FV
P
LF
F
V
LV
fig|656414.3.peg.2834
Escherichia coli H736 (16-1026/1037)
AI
L
L
C
L
T
G
TLA
I
FS
LPV
E
QYP
D
L
AP
P
N
V
R
V
T
A
N
YPGA
S
AQ
T
L
E
N
T
VT
Q
VIE
HN
M
TG
L
D
N
LM
Y
MSS
Q
S
SGT
G
QAS
V
TL
S
F
K
A
GT
D
PD
E
A
VQ
QVQ
NQ
LQ
S
A
MRK
LP
QAVQNQ
GV
TVR-KTGDT
---
N
I
LTI
A
FV
S
TDGSMDKQ
DI
A
D
Y
V
ASN
I
QDP
LS
RVN
GVG
D
I
DAY
G
SQY-SM
RI
W
LDP
AK
LN
SFQ
M
TAKD
V
TD
AI
ESQ
N
AQIAV
GQLGG
T
P
SVDKQALNAT
I
N
A
QSL
LQT
P
E
Q
F
RD
I
T
L
RVNQ
DG
SE
V
R
L
G
DVA
T
VE
M
G
A
E
KYDYL
S
RF
NGK
-
P
A
S
G
LG
V
K
L
AS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQY
FP
H
G
L
E
YKVA
Y
E
TT
SF
V
KA
SI
E
D
VVKT
L
L
EAI
A
LV
F
LV
M
YLFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
S
VL
Y
A
F
G
Y
S
V
N
T
LTM
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
E
GLT
P
RE
A
TR
K
SMG
QIQ
G
AL
VGIAMV
L
S
AVF
V
PM
A
F
FG
G
TT
G
A
IYR
Q
FSIT
IVA
AM
VL
SV
L
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWF
N
QM
F
NRNAER
----
Y
EKGVA
K
I
L
HRSLRW
I
V
I
Y
V
L
LLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IE
K
YY
FTHEKDN
I
M
SVF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFNQIKEAR
V
I--
A
S
-
SPPA
I
SGL
G
SS
A
GFDME
L
QDHAGAGH
D
A
L
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
L
D
DSPQLQ
ID
I
D
QR
KA
Q
A
L
GV
AI
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
ML
P
DD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VG
EA
APGV
S
T
G
T
A
MDIMESLVKQ
L
-
-
P
N
G
FGLE
W
T
A
--
MS
YQ
ER
L
SGAQAPA
L
Y
A
-
I
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NEMN
Q
K-
----------
G
HDLF
EA
TLH
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
S
T
GAGSG
GQHA
VG
T
GVMGGM
IS
A
T
I
LAI
Y
FV
P
LF
F
V
LV
fig|331111.12.peg.3018
Escherichia coli E24377A (16-1026/1037)
AI
L
L
C
L
T
G
TLS
I
FS
LPV
E
QYP
D
L
AP
P
N
V
R
V
T
A
N
YPGA
S
AQ
T
L
E
N
T
VT
Q
VIE
QN
M
TG
L
D
N
LM
Y
MSS
Q
S
SGT
G
QAS
V
TL
S
F
K
A
GT
D
PD
E
A
VQ
QVQ
NQ
LQ
S
A
MRK
LP
QAVQNQ
GV
TVR-KTGDT
---
N
I
LTI
A
FV
S
TDGSMDKQ
DI
A
D
Y
V
ASN
I
QDP
LS
RVN
GVG
D
I
DAY
G
SQY-SM
RI
W
LDP
AK
LN
SFQ
M
TAKD
V
TD
AI
ESQ
N
AQIAV
GQLGG
T
P
SVDKQALNAT
I
N
A
QSL
LQT
P
E
Q
F
RD
I
T
L
RVNQ
DG
SE
V
R
L
G
DVA
T
VE
M
G
A
E
KYDYL
S
RF
NGK
-
P
A
S
G
LG
V
K
L
AS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQY
FP
H
G
L
E
YKVA
Y
E
TT
SF
V
KA
SI
E
D
VVKT
L
L
EAI
A
LV
F
LV
M
YLFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
S
VL
Y
A
F
G
Y
S
V
N
T
LTM
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
E
GLT
P
RE
A
TR
K
SMG
QIQ
G
AL
VGIAMV
L
S
AVF
V
PM
A
F
FG
G
TT
G
A
IYR
Q
FSIT
IVA
AM
VL
SV
L
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWF
N
QM
F
NRNAER
----
Y
EKGVA
K
I
L
HRSLRW
I
V
I
Y
V
L
LLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IE
K
YY
FTHEKDN
I
M
SVF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFNKIKEAR
V
I--
A
S
-
SPPA
I
SGL
G
SS
A
GFDME
L
QDHAGAGH
D
A
L
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
L
D
DSPQLQ
ID
I
E
QR
KA
Q
A
L
GV
D
I
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
ML
P
DD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VG
EA
APGV
S
T
G
T
A
MDIMESLVKQ
L
-
-
P
N
G
FGLE
W
T
A
--
MS
YQ
ER
L
SGAQAPA
L
Y
A
-
I
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NEMN
Q
K-
----------
G
HDLF
EA
TLH
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
S
T
GAGSG
GQHA
VG
T
GVMGGM
IS
A
T
I
LAI
Y
FV
P
LF
F
V
LV
fig|331111.3.peg.472
Escherichia coli E24377A (16-1026/1037)
AI
L
L
C
L
T
G
TLS
I
FS
LPV
E
QYP
D
L
AP
P
N
V
R
V
T
A
N
YPGA
S
AQ
T
L
E
N
T
VT
Q
VIE
QN
M
TG
L
D
N
LM
Y
MSS
Q
S
SGT
G
QAS
V
TL
S
F
K
A
GT
D
PD
E
A
VQ
QVQ
NQ
LQ
S
A
MRK
LP
QAVQNQ
GV
TVR-KTGDT
---
N
I
LTI
A
FV
S
TDGSMDKQ
DI
A
D
Y
V
ASN
I
QDP
LS
RVN
GVG
D
I
DAY
G
SQY-SM
RI
W
LDP
AK
LN
SFQ
M
TAKD
V
TD
AI
ESQ
N
AQIAV
GQLGG
T
P
SVDKQALNAT
I
N
A
QSL
LQT
P
E
Q
F
RD
I
T
L
RVNQ
DG
SE
V
R
L
G
DVA
T
VE
M
G
A
E
KYDYL
S
RF
NGK
-
P
A
S
G
LG
V
K
L
AS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQY
FP
H
G
L
E
YKVA
Y
E
TT
SF
V
KA
SI
E
D
VVKT
L
L
EAI
A
LV
F
LV
M
YLFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
S
VL
Y
A
F
G
Y
S
V
N
T
LTM
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
E
GLT
P
RE
A
TR
K
SMG
QIQ
G
AL
VGIAMV
L
S
AVF
V
PM
A
F
FG
G
TT
G
A
IYR
Q
FSIT
IVA
AM
VL
SV
L
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWF
N
QM
F
NRNAER
----
Y
EKGVA
K
I
L
HRSLRW
I
V
I
Y
V
L
LLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IE
K
YY
FTHEKDN
I
M
SVF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFNKIKEAR
V
I--
A
S
-
SPPA
I
SGL
G
SS
A
GFDME
L
QDHAGAGH
D
A
L
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
L
D
DSPQLQ
ID
I
E
QR
KA
Q
A
L
GV
D
I
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
ML
P
DD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VG
EA
APGV
S
T
G
T
A
MDIMESLVKQ
L
-
-
P
N
G
FGLE
W
T
A
--
MS
YQ
ER
L
SGAQAPA
L
Y
A
-
I
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NEMN
Q
K-
----------
G
HDLF
EA
TLH
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
S
T
GAGSG
GQHA
VG
T
GVMGGM
IS
A
T
I
LAI
Y
FV
P
LF
F
V
LV
fig|656437.3.peg.2792
Escherichia coli TA143 (16-1026/1037)
AI
L
L
C
L
T
G
TLA
I
FS
LPV
E
QYP
D
L
AP
P
N
V
R
V
T
A
N
YPGA
S
AQ
T
L
E
N
T
VT
Q
VIE
QN
M
TG
L
D
N
LM
Y
MSS
Q
S
SGT
G
QAS
V
TL
S
F
K
A
GT
D
PD
E
A
VQ
QVQ
NQ
LQ
S
A
MRK
LP
QAVQNQ
GV
MVR-KTGDT
---
N
I
LTI
A
FV
S
TDGSMDKQ
DI
A
D
Y
V
ASN
I
QDP
LS
RVN
GVG
D
I
DAY
G
SQY-SM
RI
W
LDP
AK
LN
SFQ
M
TAKD
V
TD
AI
ESQ
N
AQIAV
GQLGG
T
P
SVDKQALNAT
I
N
A
QSL
LQT
P
E
Q
F
RD
I
T
L
RVNQ
DG
SE
V
R
L
G
DVA
T
VE
M
G
A
E
KYDYL
S
RF
NGK
-
P
A
S
G
LG
V
K
L
AS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQY
FP
H
G
L
E
YKVA
Y
E
TT
SF
V
KA
SI
E
D
VVKT
L
L
EAI
A
LV
F
LV
M
YLFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
S
VL
Y
A
F
G
Y
S
V
N
T
LTM
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
E
GLT
P
RE
A
TR
K
SMG
QIQ
G
AL
VGIAMV
L
S
AVF
V
PM
A
F
FG
G
TT
G
A
IYR
Q
FSIT
IVA
AM
VL
SV
L
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWF
N
QM
F
NRNAER
----
Y
EKGVA
K
I
L
HRSLRW
I
V
I
Y
V
L
LLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IE
K
YY
FTHEKDN
I
M
SVF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFNKIKEAR
V
I--
A
S
-
SPPA
I
SGL
G
SS
A
GFDME
L
QDHAGAGH
D
A
L
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
L
D
DSPQLQ
ID
I
D
QR
KA
Q
A
L
GV
AI
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
ML
P
DD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VG
EA
APGV
S
T
G
T
A
MDIMESLVKQ
L
-
-
P
N
G
FGLE
W
T
A
--
MS
YQ
ER
L
SGAQAPA
L
Y
A
-
I
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NEMN
Q
K-
----------
G
HDLF
EA
TLH
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
S
T
GAGSG
GQHA
VG
T
GVMGGM
IS
A
T
I
LAI
Y
FV
P
LF
F
V
LV
fig|749531.3.peg.2713
Escherichia coli MS 69-1 (16-1026/1037)
AI
L
L
C
L
T
G
TLA
I
FS
LPV
E
QYP
D
L
AP
P
N
V
R
V
T
A
N
YPGA
S
AQ
T
L
E
N
T
VT
Q
VIE
QN
M
TG
L
D
N
LM
Y
MSS
Q
S
SGT
G
QAS
V
TL
S
F
K
A
GT
D
PD
E
A
VQ
QVQ
NQ
LQ
S
A
MRK
LP
QAVQNQ
GV
TVR-KTGDT
---
N
I
LTI
A
FV
S
TDGSMDKQ
DI
A
D
Y
V
ASN
I
QDP
LS
RVN
GVG
D
I
DAY
G
SQY-SM
RI
W
LDP
AK
LN
SFQ
M
TAKD
V
TD
AI
ESQ
N
AQIAV
GQLGG
T
P
SVDKQALNAT
I
N
A
QSL
LQT
P
E
Q
F
RD
I
T
L
RVNQ
DG
SE
V
R
L
G
DVA
T
VE
M
G
A
E
KYDYL
S
RF
NGK
-
P
A
S
G
LG
V
K
L
AS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQY
FP
H
G
L
E
YKVA
Y
E
TT
SF
V
KA
SI
E
D
VVKT
L
L
EAI
A
LV
F
LV
M
YLFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
S
VL
Y
A
F
G
Y
S
V
N
T
LTM
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
E
GLT
P
RE
A
TR
K
SMG
QIQ
G
AL
VGIAMV
L
S
AVF
V
PM
A
F
FG
G
TT
G
A
IYR
Q
FSIT
IVA
AM
VL
SV
L
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWF
N
QM
F
NRNAER
----
Y
EKGVA
K
I
L
HRSLRW
I
V
I
Y
V
L
LLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IE
K
YY
FTHEKDN
I
M
SVF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFNKIKEAR
V
I--
A
S
-
SPPA
I
SGL
G
SS
A
GFDME
L
QDHAGAGH
D
A
L
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
L
D
DSPQLQ
ID
I
D
QR
KA
Q
A
L
GV
AI
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
ML
P
DD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VG
EA
APGV
S
T
G
T
A
MDIMESLVKQ
L
-
-
P
N
G
FGLE
W
T
E
--
MS
YQ
ER
L
SGAQAPA
L
Y
A
-
I
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NEMN
Q
K-
----------
G
HDLF
EA
TLH
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
S
T
GAGSG
GQHA
VG
T
GVMGGM
IS
A
T
I
LAI
Y
FV
P
LF
F
V
LV
fig|749545.3.peg.420
Escherichia coli MS 182-1 (16-1026/1037)
AI
L
L
C
L
T
G
TLA
I
FS
LPV
E
QYP
D
L
AP
P
N
V
R
V
T
A
N
YPGA
S
AQ
T
L
E
N
T
VT
Q
VIE
QN
M
TG
L
D
N
LM
Y
MSS
Q
S
SGT
G
QAS
V
TL
S
F
K
A
GT
D
PD
E
A
VQ
QVQ
NQ
LQ
S
A
MRK
LP
QAVQNQ
GV
TVR-KTGDT
---
N
I
LTI
A
FV
S
TDGSMDKQ
DI
A
D
Y
V
ASN
I
QDP
LS
RVN
GVG
D
I
DAY
G
SQY-SM
RI
W
LDP
AK
LN
SFQ
M
TAKD
V
TD
AI
ESQ
N
AQIAV
GQLGG
T
P
SVDKQALNAT
I
N
A
QSL
LQT
P
E
Q
F
RD
I
T
L
RVNQ
DG
SE
V
R
L
G
DVA
T
VE
M
G
A
E
KYDYL
S
RF
NGK
-
P
A
S
G
LG
V
K
L
AS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQY
FP
H
G
L
E
YKVA
Y
E
TT
SF
V
KA
SI
E
D
VVKT
L
L
EAI
A
LV
F
LV
M
YLFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
S
VL
Y
A
F
G
Y
S
V
N
T
LTM
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
E
GLT
P
RE
A
TR
K
SMG
QIQ
G
AL
VGIAMV
L
S
AVF
V
PM
A
F
FG
G
PT
G
A
IYR
Q
FSIT
IVA
AM
VL
SV
L
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWF
N
QM
F
NRNAER
----
Y
EKGVA
K
I
L
HRSLRW
I
V
I
Y
V
L
LLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IE
K
YY
FTHEKDN
I
M
SVF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFNKIKEAR
V
I--
A
S
-
SPPA
I
SGL
G
SS
A
GFDME
L
QDHAGAGH
D
A
L
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
L
D
DSPQLQ
ID
I
D
QR
KA
Q
A
L
GV
D
I
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
ML
P
DD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VG
EA
APGV
S
T
G
T
A
MDIMESLVKQ
L
-
-
P
N
G
FGLE
W
T
A
--
MS
YQ
ER
L
SGAQAPA
L
Y
A
-
I
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NEMN
Q
K-
----------
G
HDLF
EA
TLH
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
S
T
GAGSG
GQHA
VG
T
GVMGGM
IS
A
T
I
LAI
Y
FV
P
LF
F
V
LV
fig|679207.4.peg.2750
Escherichia coli MS 107-1 (16-1026/1037)
AI
L
L
C
L
T
G
TLA
I
FS
LPV
E
QYP
D
L
AP
P
N
V
R
V
T
A
N
YPGA
S
AQ
T
L
E
N
T
VT
Q
VIE
QN
M
TG
L
D
N
LM
Y
MSS
Q
S
SGT
G
QAS
V
TL
S
F
K
A
GT
D
PD
E
A
VQ
QVQ
NQ
LQ
S
A
MRK
LP
QAVQNQ
GV
TVR-KTGDT
---
N
I
LTI
A
FV
S
TDGSMDKQ
DI
A
D
Y
V
ASN
I
QDP
LS
RVN
GVG
D
I
DAY
G
SQY-SM
RI
W
LDP
AK
LN
SFQ
M
TAKD
V
TD
AI
ESQ
N
AQIAV
GQLGG
T
P
SVDKQALNAT
I
N
A
QSL
LQT
P
E
Q
F
RD
I
T
L
RVNQ
DG
SE
V
R
L
G
DVA
T
VE
M
G
A
E
KYDYL
S
RF
NGK
-
P
A
S
G
LG
V
K
L
AS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQY
FP
H
G
L
E
YKVA
Y
E
TT
SF
V
KA
SI
E
D
VVKT
L
L
EAI
A
LV
F
LV
M
YLFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
S
VL
Y
A
F
G
Y
S
V
N
T
LTM
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
E
GLT
P
RE
A
TR
K
SMG
QIQ
G
AL
VGIAMV
L
S
AVF
V
PM
A
F
FG
G
TT
G
A
IYR
Q
FSIT
IVA
AM
VL
SV
L
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWF
N
QM
F
NRNAER
----
Y
EKGVA
K
I
L
HRSLRW
I
V
I
Y
V
L
LLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IE
K
YY
FTHEKDN
I
M
SVF
ATI
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFNKIKEAR
V
I--
A
S
-
SPPA
I
SGL
G
SS
A
GFDME
L
QDHAGAGH
D
A
L
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
L
D
DSPQLQ
ID
I
D
QR
KA
Q
A
L
GV
D
I
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
ML
P
DD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VG
EA
APGV
S
T
G
T
A
MDIMESLVKQ
L
-
-
P
N
G
FGLE
W
T
A
--
MS
YQ
ER
L
SGAQAPA
L
Y
A
-
I
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NEMN
Q
K-
----------
G
HDLF
EA
TLH
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
S
T
GAGSG
GQHA
VG
T
GVMGGM
IS
A
T
I
LAI
Y
FV
P
LF
F
V
LV
fig|331112.3.peg.2439
Escherichia coli HS (16-1026/1037)
AI
L
L
C
L
T
G
TLA
I
FS
LPV
E
QYP
D
L
AP
P
N
V
R
V
T
A
N
YPGA
S
AQ
T
L
E
N
T
VT
Q
VIE
QN
M
TG
L
D
N
LM
Y
MSS
Q
S
SGT
G
QAS
V
TL
S
F
K
A
GT
D
PD
E
A
VQ
QVQ
NQ
LQ
S
A
MRK
LP
QAVQNQ
GV
TVR-KTGDT
---
N
I
LTI
A
FV
S
TDGSMDKQ
DI
A
D
Y
V
ASN
I
QDP
LS
RVN
GVG
D
I
DAY
G
SQY-SM
RI
W
LDP
AK
LN
SFQ
M
TAKD
V
TD
AI
ESQ
N
AQIAV
GQLGG
T
P
SVDKQALNAT
I
N
A
QSL
LQT
P
E
Q
F
RD
I
T
L
RVNQ
DG
SE
V
R
L
G
DVA
T
VE
M
G
A
E
KYDYL
S
RF
NGK
-
P
A
S
G
LG
V
K
L
AS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQY
FP
H
G
L
E
YKVA
Y
E
TT
SF
V
KA
SI
E
D
VVKT
L
L
EAI
A
LV
F
LV
M
YLFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
S
VL
Y
A
F
G
Y
S
V
N
T
LTM
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
E
GLT
P
RE
A
TR
K
SMG
QIQ
G
AL
VGIAMV
L
S
AVF
V
PM
A
F
FG
G
IT
G
A
IYR
Q
FSIT
IVA
AM
VL
SV
L
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWF
N
QM
F
NRNAER
----
Y
EKGVA
K
I
L
HRSLRW
I
V
I
Y
V
L
LLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IE
K
YY
FTHEKDN
I
M
SVF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFNQIKEAR
V
I--
A
S
-
SPPA
I
SGL
G
SS
A
GFDME
L
QDHAGAGH
D
A
L
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
L
D
DSPQLQ
ID
I
D
QR
KA
Q
A
L
GV
AI
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
ML
P
DD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VG
EA
APGV
S
T
G
T
T
MDIMESLVKQ
L
-
-
P
N
G
FGLE
W
T
A
--
MS
YQ
ER
L
SGAQAPA
L
Y
A
-
I
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NEMN
Q
K-
----------
G
HDLF
EA
TLH
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
S
T
GAGSG
GQHA
VG
T
GVMGGM
IS
A
T
I
LAI
Y
FV
P
LF
F
V
LV
fig|331112.6.peg.2543
Escherichia coli HS (16-1026/1037)
AI
L
L
C
L
T
G
TLA
I
FS
LPV
E
QYP
D
L
AP
P
N
V
R
V
T
A
N
YPGA
S
AQ
T
L
E
N
T
VT
Q
VIE
QN
M
TG
L
D
N
LM
Y
MSS
Q
S
SGT
G
QAS
V
TL
S
F
K
A
GT
D
PD
E
A
VQ
QVQ
NQ
LQ
S
A
MRK
LP
QAVQNQ
GV
TVR-KTGDT
---
N
I
LTI
A
FV
S
TDGSMDKQ
DI
A
D
Y
V
ASN
I
QDP
LS
RVN
GVG
D
I
DAY
G
SQY-SM
RI
W
LDP
AK
LN
SFQ
M
TAKD
V
TD
AI
ESQ
N
AQIAV
GQLGG
T
P
SVDKQALNAT
I
N
A
QSL
LQT
P
E
Q
F
RD
I
T
L
RVNQ
DG
SE
V
R
L
G
DVA
T
VE
M
G
A
E
KYDYL
S
RF
NGK
-
P
A
S
G
LG
V
K
L
AS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQY
FP
H
G
L
E
YKVA
Y
E
TT
SF
V
KA
SI
E
D
VVKT
L
L
EAI
A
LV
F
LV
M
YLFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
S
VL
Y
A
F
G
Y
S
V
N
T
LTM
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
E
GLT
P
RE
A
TR
K
SMG
QIQ
G
AL
VGIAMV
L
S
AVF
V
PM
A
F
FG
G
IT
G
A
IYR
Q
FSIT
IVA
AM
VL
SV
L
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWF
N
QM
F
NRNAER
----
Y
EKGVA
K
I
L
HRSLRW
I
V
I
Y
V
L
LLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IE
K
YY
FTHEKDN
I
M
SVF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFNQIKEAR
V
I--
A
S
-
SPPA
I
SGL
G
SS
A
GFDME
L
QDHAGAGH
D
A
L
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
L
D
DSPQLQ
ID
I
D
QR
KA
Q
A
L
GV
AI
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
ML
P
DD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VG
EA
APGV
S
T
G
T
T
MDIMESLVKQ
L
-
-
P
N
G
FGLE
W
T
A
--
MS
YQ
ER
L
SGAQAPA
L
Y
A
-
I
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NEMN
Q
K-
----------
G
HDLF
EA
TLH
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
S
T
GAGSG
GQHA
VG
T
GVMGGM
IS
A
T
I
LAI
Y
FV
P
LF
F
V
LV
fig|679204.3.peg.1632
Escherichia coli MS 145-7 (16-1026/1037)
AI
L
L
C
L
T
G
TLA
I
FS
LPV
E
QYP
D
L
AP
P
N
V
R
V
T
A
N
YPGA
S
AQ
T
L
E
N
T
VT
Q
VIE
QN
M
TG
L
D
N
LM
Y
MSS
Q
S
SGT
G
QAS
V
TL
S
F
K
A
GT
D
PD
E
A
VQ
QVQ
NQ
LQ
S
A
MRK
LP
QAVQNQ
GV
TVR-KTGDT
---
N
I
LTI
A
FV
S
TDGSMDKQ
DI
A
D
Y
V
ASN
I
QDP
LS
RVN
GVG
D
I
DAY
G
SQY-SM
RI
W
LDP
AK
LN
SFQ
M
TAKD
V
TD
AI
ESQ
N
AQIAV
GQLGG
T
P
SVDKQALNAT
I
N
A
QSL
LQT
P
E
Q
F
RD
I
T
L
RVNQ
DG
SE
V
R
L
G
DVA
T
VE
M
G
A
E
KYDYL
S
RF
NGK
-
P
A
S
G
LG
V
K
L
AS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQY
FP
H
G
L
E
YKVA
Y
E
TT
SF
V
KA
SI
E
D
VVKT
L
L
EAI
A
LV
F
LV
M
YLFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
S
VL
Y
A
F
G
Y
S
V
N
T
LTM
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
E
GLT
P
RE
A
TR
K
SMG
QIQ
G
AL
VGIAMV
L
S
AVF
V
PM
A
F
FG
G
TT
G
A
IYR
Q
FSIT
IVA
AM
VL
SV
L
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWF
N
QM
F
NRNAER
----
Y
EKGVA
K
I
L
HRSLRW
I
V
I
Y
V
L
LLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IE
K
YY
FTHEKDN
I
M
SVF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFNKIKEAR
V
I--
A
S
-
SPPA
I
SGL
G
SS
A
GFDME
L
QDHAGAGH
D
A
L
MAARN
QL
LVL
A
AEN
P
-E
L
TR
V
RH
N
G
L
D
DSPQLQ
ID
I
D
QR
KA
Q
A
L
GV
D
I
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
ML
P
DD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VG
EA
APGV
S
T
G
T
A
MDIMESLVKQ
L
-
-
P
N
G
FGLE
W
T
A
--
MS
YQ
ER
L
SGAQAPA
L
Y
A
-
I
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NEMN
Q
K-
----------
G
HDLF
EA
TLH
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
S
T
GAGSG
GQHA
VG
T
GVMGGM
IS
A
T
I
LAI
Y
FV
P
LF
F
V
LV
fig|155864.8.peg.3235
Escherichia coli O157:H7 EDL933 (16-1026/1037)
AI
L
L
C
L
T
G
TLA
I
FS
LPV
E
QYP
D
L
AP
P
N
V
R
V
T
A
N
YPGA
S
AQ
T
L
E
N
T
VT
Q
VIE
QN
M
TG
L
D
N
LM
Y
MSS
Q
S
SGT
G
QAS
V
TL
S
F
K
A
GT
D
PD
E
A
VQ
QVQ
NQ
LQ
S
A
MRK
LP
QAVQNQ
GV
TVR-KTGDT
---
N
I
LTI
A
FV
S
TDGSMDKQ
DI
A
D
Y
V
ASN
I
QDP
LS
RVN
GVG
D
I
DAY
G
SQY-SM
RI
W
LDP
AK
LN
SFQ
M
TAKD
V
TD
AI
ESQ
N
AQIAV
GQLGG
T
P
SVDKQALNAT
I
N
A
QSL
LQT
P
E
Q
F
RD
I
T
L
RVNQ
DG
SE
V
R
L
G
DVA
T
A
E
M
G
A
E
KYDYL
S
RF
NGK
-
P
A
S
G
LG
V
K
L
AS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQY
FP
H
G
L
E
YKVA
Y
E
TT
SF
V
KA
SI
E
D
VVKT
L
L
EAI
A
LV
F
LV
M
YLFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
S
VL
Y
A
F
G
Y
S
V
N
T
LTM
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
E
GLT
P
RE
A
TR
K
SMG
QIQ
G
AL
VGIAMV
L
S
AVF
V
PM
A
F
FG
G
TT
G
A
IYR
Q
FSIT
IVA
AM
VL
SV
L
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWF
N
QM
F
NRNAER
----
Y
EKGVA
K
I
L
HRSLRW
I
V
I
Y
V
L
LLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTXKVVE
Q
IE
K
YY
FTHEKDN
I
M
SVF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFNQIKEAR
V
I--
A
S
-
SPPA
I
SGL
G
SS
A
GFDME
L
QDHAGAGH
D
A
L
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
L
D
DSPQLQ
ID
I
D
QR
KA
Q
A
L
GV
AI
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
ML
P
DD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VG
EA
APGV
S
T
G
T
A
MDIMESLVKQ
L
-
-
P
N
G
FGLE
W
T
A
--
MS
YQ
ER
L
SGAQAPA
L
Y
A
-
I
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NEMN
Q
K-
----------
G
HDLF
EA
TLH
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
S
T
GAGSG
GQHA
VG
T
GVMGGM
IS
A
T
I
LAI
Y
FV
P
LF
F
V
LV
fig|670897.3.peg.2991
Escherichia coli 2362-75 (17-1021/1040)
I
M
RPVA
TTL
L
----
M
V
A
I
L
L
A
G
IIG
Y
QA
LPV
S
AL
P
E
V
DY
P
T
I
Q
V
V
T
L
YPGA
S
PD
V
M
T
S
A
VT
A
PL
E
RQ
F
GQ
M
S
GL
K
Q
MSS
Q
S
SG-
G
ASV
ITL
Q
F
Q
L
TL
P
L
D
V
A
EQ
E
VQ
AA
IN
A
A
TNL
LP
SDLPNP
P
V
YSKVNPADP
---
P
I
MTL
A
VT
S
T--AMPMT
Q
V
E
D
M
V
ETR
V
AQK
I
S
QIS
GVG
L
V
TLS
G
GQRPAV
R
V
K
L
NA
QA
IA
ALG
L
TSET
V
RT
AI
TGA
N
VNSAK
G
S
L
--
-
-
--DGPSRAVT
L
S
A
NDQ
M
Q
S
A
EE
Y
RQ
L
I
I
AYQ-
N
G
AP
I
R
L
G
DVA
T
VE
Q
G
A
E
NSWLG
A
WA
N
K
E
-
Q
A
I
V
MN
V
Q
R
QP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TES
L
P
K
S
VK
VTVL
S
D
R
T
TN
I
RA
S
V
D
D
TQFE
L
M
M
AI
A
LV
V
M
I
I
YLFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
A
V
M
V
F
L
D
F
S
I
N
N
LT
L
M
A
L
T
I
A
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
K
GEK
P
LA
A
AL
N
GAG
E
I
G
F
TI
ISLTFS
L
I
AV
L
IP
L
L
F
MG
D
IV
G
R
LF
R
E
F
A
IT
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRAS
E
KM
F
ERIIAA
----
Y
GQGLA
KVL
NHPWLT
L
S
V
A
L
S
TLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VA
D
--
VILQDPA
V
Q
S
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQ
V
SR
T
QYQFT
L
QAT---SL
D
A
L
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
QD
KGLVAY
VNVD
RD
S
A
S
R
L
G
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
L
E
HNTEN
T
PG
L
AA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SF
N
V
PDNY
S
L
G
D
A
VQAIMDTEKT
L
N
L
P
V
D
ITTQ
F
Q
G
ST
LA
F
Q
SA
L
GS--TVW
L
I
V
-
A
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAE
R
EQ
----------
G
MSPR
D
A
IYQ
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
IV
S
Q
V
L
T
L
F
TT
P
VI
Y
L
L
fig|550677.3.peg.1624
Escherichia coli B354 (17-1021/1040)
I
M
RPVA
TTL
L
----
M
V
A
I
L
L
A
G
IIG
Y
RA
LPV
S
AL
P
E
V
DY
P
T
I
Q
V
V
T
L
YPGA
S
PD
V
M
T
S
A
VT
A
PL
E
RQ
F
GQ
M
S
GL
K
Q
MSS
Q
S
SG-
G
ASV
ITL
Q
F
Q
L
TL
P
L
D
V
A
EQ
E
VQ
AA
IN
A
A
TNL
LP
SDLPNP
P
V
YSKVNPADP
---
P
I
MTL
A
VT
S
T--AMPMT
Q
V
E
D
M
V
ETR
V
AQK
I
S
QIS
GVG
L
V
TLS
G
GQRPAV
R
V
K
L
NA
QA
IA
ALG
L
TSET
V
RT
AI
TGA
N
VNSAK
G
S
L
--
-
-
--DGPSRAVT
L
S
A
NDQ
M
Q
S
A
EE
Y
RQ
L
I
I
AYQ-
N
G
AP
I
R
L
G
DVA
T
VE
Q
G
A
E
NSWLG
A
WA
N
K
E
-
Q
A
I
V
MN
V
Q
R
QP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TES
L
P
K
S
VK
VTVL
S
D
R
T
TN
I
RA
S
V
D
D
TQFE
L
M
M
AI
A
LV
V
M
I
I
YLFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
A
V
M
V
F
L
D
F
S
I
N
N
LT
L
M
A
L
T
I
A
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
K
GEK
P
LA
A
AL
K
GAG
E
I
G
F
TI
ISLTFS
L
I
AV
L
IP
L
L
F
MG
D
IV
G
R
LF
R
E
F
A
IT
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRAS
E
KM
F
DRIIAA
----
Y
GRGLA
KVL
NHPWLT
L
S
V
A
L
S
TLLLSVL
L
WVLI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VA
D
--
VILQDPA
V
Q
S
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQ
V
SR
T
QYQFT
L
QAT---SL
D
A
L
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
QD
KGLVAY
VNVD
RD
S
A
S
R
L
G
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
L
E
HNTEN
T
PG
L
AA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SF
N
V
PDNY
S
L
G
D
A
VQAIMDTEKT
L
N
L
P
V
D
ITTQ
F
Q
G
ST
LA
F
Q
SA
L
GS--TVW
L
I
V
-
A
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAE
R
EQ
----------
G
MSPR
D
A
IYQ
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
IV
S
Q
V
L
T
L
F
TT
P
VI
Y
L
L
fig|749528.3.peg.1606
Escherichia coli MS 45-1 (17-1021/1040)
I
M
RPVA
TTL
L
----
M
V
A
I
L
L
A
G
IIG
Y
RA
LPV
S
AL
P
E
V
DY
P
T
I
Q
V
V
T
L
YPGA
S
PD
V
M
T
S
A
VT
A
PL
E
RQ
F
GQ
M
S
GL
K
Q
MSS
Q
S
SG-
G
ASV
ITL
Q
F
Q
L
TL
P
L
D
V
A
EQ
E
VQ
AA
IN
A
A
TNL
LP
SDLPNP
P
V
YSKVNPADP
---
P
I
MTL
A
VT
S
T--AMPMT
Q
V
E
D
M
V
ETR
V
AQK
I
S
QIS
GVG
L
V
TLS
G
GQRPAV
R
V
K
L
NA
QA
IA
ALG
L
TSET
V
RT
AI
TGA
N
VNSAK
G
S
L
--
-
-
--DGPSRAVT
L
S
A
NDQ
M
Q
S
A
EE
Y
RQ
L
I
I
AYQ-
N
G
AP
I
R
L
G
DVA
T
VE
Q
G
A
E
NSWLG
A
WA
N
K
E
-
Q
A
I
V
MN
V
Q
R
QP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TES
L
P
K
S
VK
VTVL
S
D
R
T
TN
I
RA
S
V
D
D
TQFE
L
M
M
AI
A
LV
V
M
I
I
YLFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
A
V
M
V
F
L
D
F
S
I
N
N
LT
L
M
A
L
T
I
A
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
K
GEK
P
LA
A
AL
K
GAG
E
I
G
F
TI
ISLTFS
L
I
AV
L
IP
L
L
F
IG
D
IV
G
R
LF
R
E
F
A
IT
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRAS
E
KM
F
DRIIAA
----
Y
GRGLA
KVL
NHPWLT
L
S
V
A
L
S
TLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VA
D
--
VILQDPA
V
Q
S
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQ
V
GR
T
QYQFT
L
QAT---SL
D
A
L
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
QD
KGLVAY
VNVD
RD
S
A
S
R
L
G
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
L
E
HNTEN
T
PG
L
AA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SF
N
V
PDNY
S
L
G
D
A
VQAIMDTEKT
L
N
L
P
V
D
ITTQ
F
Q
G
ST
LA
F
Q
SA
L
GS--TVW
L
I
V
-
A
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAE
R
EQ
----------
G
MSPR
EA
IYQ
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
IV
S
Q
V
L
T
L
F
TT
P
VI
Y
L
L
fig|562.373.peg.3655
Escherichia coli 1125A (16-1026/1037)
AI
L
L
C
L
T
G
TLA
I
FS
LPV
E
QYP
D
L
AP
P
N
V
R
V
T
A
N
YPGA
S
AQ
T
L
E
N
T
VT
Q
VIE
QN
M
TG
L
D
N
LM
Y
MSS
Q
S
SGT
G
QAS
V
TL
S
F
K
A
GT
D
PD
E
A
VQ
QVQ
NQ
LQ
S
A
MRK
LP
QAVQNQ
GV
TVR-KTGDT
---
N
I
LTI
A
FV
S
TDGSMDKQ
DI
A
D
Y
V
ASN
I
QDP
LS
RVN
GVG
D
I
DAY
G
SQY-SM
RI
W
LDP
AK
LN
SFQ
M
TAKD
V
TD
AI
ESQ
N
AQIAV
GQLGG
T
P
SVDKQALNAT
I
N
A
QSL
LQT
P
E
Q
F
RD
I
T
L
RVNQ
DG
SE
V
R
L
G
DVA
T
A
E
M
G
A
E
KYDYL
S
RF
NGK
-
P
A
S
G
LG
V
K
L
AS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQY
FP
H
G
L
E
YKVA
Y
E
TT
SF
V
KA
SI
E
D
VVKT
L
L
EAI
A
LV
F
LV
M
YLFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
S
VL
Y
A
F
G
Y
S
V
N
T
LTM
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
E
GLT
P
RE
A
TR
K
SMG
QIQ
G
AL
VGIAMV
L
S
AVF
V
PM
A
F
FG
G
TT
G
A
IYR
Q
FSIT
IVA
AM
VL
SV
L
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWF
N
QM
F
NRNAER
----
Y
EKGVA
K
I
L
HRSLRW
I
V
I
Y
V
L
LLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IE
K
YY
FTHEKDN
I
M
SVF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFNQIKEAR
V
I--
A
S
-
SPPA
I
SGL
G
SS
A
GFDME
L
QDHAGAGH
D
A
L
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
L
D
DSPQLQ
ID
I
D
QR
KA
Q
A
L
GV
AI
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
ML
P
DD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VG
EA
APGV
S
T
G
T
A
MDIMESLVKQ
L
-
-
P
N
G
FGLE
W
T
A
--
MS
YQ
ER
L
SGAQAPA
L
Y
A
-
I
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NEMN
Q
K-
----------
G
HDLF
EA
TLH
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
S
T
GAGSG
GQHA
VG
T
GVMGGM
IS
A
T
I
LAI
Y
FV
P
LF
F
V
LV
fig|562.372.peg.1878
Escherichia coli 1212A (16-1026/1037)
AI
L
L
C
L
T
G
TLA
I
FS
LPV
E
QYP
D
L
AP
P
N
V
R
V
T
A
N
YPGA
S
AQ
T
L
E
N
T
VT
Q
VIE
QN
M
TG
L
D
N
LM
Y
MSS
Q
S
SGT
G
QAS
V
TL
S
F
K
A
GT
D
PD
E
A
VQ
QVQ
NQ
LQ
S
A
MRK
LP
QAVQNQ
GV
TVR-KTGDT
---
N
I
LTI
A
FV
S
TDGSMDKQ
DI
A
D
Y
V
ASN
I
QDP
LS
RVN
GVG
D
I
DAY
G
SQY-SM
RI
W
LDP
AK
LN
SFQ
M
TAKD
V
TD
AI
ESQ
N
AQIAV
GQLGG
T
P
SVDKQALNAT
I
N
A
QSL
LQT
P
E
Q
F
RD
I
T
L
RVNQ
DG
SE
V
R
L
G
DVA
T
A
E
M
G
A
E
KYDYL
S
RF
NGK
-
P
A
S
G
LG
V
K
L
AS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQY
FP
H
G
L
E
YKVA
Y
E
TT
SF
V
KA
SI
E
D
VVKT
L
L
EAI
A
LV
F
LV
M
YLFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
S
VL
Y
A
F
G
Y
S
V
N
T
LTM
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
E
GLT
P
RE
A
TR
K
SMG
QIQ
G
AL
VGIAMV
L
S
AVF
V
PM
A
F
FG
G
TT
G
A
IYR
Q
FSIT
IVA
AM
VL
SV
L
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWF
N
QM
F
NRNAER
----
Y
EKGVA
K
I
L
HRSLRW
I
V
I
Y
V
L
LLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IE
K
YY
FTHEKDN
I
M
SVF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFNQIKEAR
V
I--
A
S
-
SPPA
I
SGL
G
SS
A
GFDME
L
QDHAGAGH
D
A
L
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
L
D
DSPQLQ
ID
I
D
QR
KA
Q
A
L
GV
AI
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
ML
P
DD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VG
EA
APGV
S
T
G
T
A
MDIMESLVKQ
L
-
-
P
N
G
FGLE
W
T
A
--
MS
YQ
ER
L
SGAQAPA
L
Y
A
-
I
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NEMN
Q
K-
----------
G
HDLF
EA
TLH
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
S
T
GAGSG
GQHA
VG
T
GVMGGM
IS
A
T
I
LAI
Y
FV
P
LF
F
V
LV
fig|562.374.peg.3080
Escherichia coli 536A (16-1026/1037)
AI
L
L
C
L
T
G
TLA
I
FS
LPV
E
QYP
D
L
AP
P
N
V
R
V
T
A
N
YPGA
S
AQ
T
L
E
N
T
VT
Q
VIE
QN
M
TG
L
D
N
LM
Y
MSS
Q
S
SGT
G
QAS
V
TL
S
F
K
A
GT
D
PD
E
A
VQ
QVQ
NQ
LQ
S
A
MRK
LP
QAVQNQ
GV
TVR-KTGDT
---
N
I
LTI
A
FV
S
TDGSMDKQ
DI
A
D
Y
V
ASN
I
QDP
LS
RVN
GVG
D
I
DAY
G
SQY-SM
RI
W
LDP
AK
LN
SFQ
M
TAKD
V
TD
AI
ESQ
N
AQIAV
GQLGG
T
P
SVDKQALNAT
I
N
A
QSL
LQT
P
E
Q
F
RD
I
T
L
RVNQ
DG
SE
V
R
L
G
DVA
T
A
E
M
G
A
E
KYDYL
S
RF
NGK
-
P
A
S
G
LG
V
K
L
AS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQY
FP
H
G
L
E
YKVA
Y
E
TT
SF
V
KA
SI
E
D
VVKT
L
L
EAI
A
LV
F
LV
M
YLFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
S
VL
Y
A
F
G
Y
S
V
N
T
LTM
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
E
GLT
P
RE
A
TR
K
SMG
QIQ
G
AL
VGIAMV
L
S
AVF
V
PM
A
F
FG
G
TT
G
A
IYR
Q
FSIT
IVA
AM
VL
SV
L
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWF
N
QM
F
NRNAER
----
Y
EKGVA
K
I
L
HRSLRW
I
V
I
Y
V
L
LLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IE
K
YY
FTHEKDN
I
M
SVF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFNQIKEAR
V
I--
A
S
-
SPPA
I
SGL
G
SS
A
GFDME
L
QDHAGAGH
D
A
L
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
L
D
DSPQLQ
ID
I
D
QR
KA
Q
A
L
GV
AI
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
ML
P
DD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VG
EA
APGV
S
T
G
T
A
MDIMESLVKQ
L
-
-
P
N
G
FGLE
W
T
A
--
MS
YQ
ER
L
SGAQAPA
L
Y
A
-
I
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NEMN
Q
K-
----------
G
HDLF
EA
TLH
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
S
T
GAGSG
GQHA
VG
T
GVMGGM
IS
A
T
I
LAI
Y
FV
P
LF
F
V
LV
fig|155864.1.peg.3330
Escherichia coli O157:H7 EDL933 (16-1026/1037)
AI
L
L
C
L
T
G
TLA
I
FS
LPV
E
QYP
D
L
AP
P
N
V
R
V
T
A
N
YPGA
S
AQ
T
L
E
N
T
VT
Q
VIE
QN
M
TG
L
D
N
LM
Y
MSS
Q
S
SGT
G
QAS
V
TL
S
F
K
A
GT
D
PD
E
A
VQ
QVQ
NQ
LQ
S
A
MRK
LP
QAVQNQ
GV
TVR-KTGDT
---
N
I
LTI
A
FV
S
TDGSMDKQ
DI
A
D
Y
V
ASN
I
QDP
LS
RVN
GVG
D
I
DAY
G
SQY-SM
RI
W
LDP
AK
LN
SFQ
M
TAKD
V
TD
AI
ESQ
N
AQIAV
GQLGG
T
P
SVDKQALNAT
I
N
A
QSL
LQT
P
E
Q
F
RD
I
T
L
RVNQ
DG
SE
V
R
L
G
DVA
T
A
E
M
G
A
E
KYDYL
S
RF
NGK
-
P
A
S
G
LG
V
K
L
AS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQY
FP
H
G
L
E
YKVA
Y
E
TT
SF
V
KA
SI
E
D
VVKT
L
L
EAI
A
LV
F
LV
M
YLFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
S
VL
Y
A
F
G
Y
S
V
N
T
LTM
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
E
GLT
P
RE
A
TR
K
SMG
QIQ
G
AL
VGIAMV
L
S
AVF
V
PM
A
F
FG
G
TT
G
A
IYR
Q
FSIT
IVA
AM
VL
SV
L
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWF
N
QM
F
NRNAER
----
Y
EKGVA
K
I
L
HRSLRW
I
V
I
Y
V
L
LLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IE
K
YY
FTHEKDN
I
M
SVF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFNQIKEAR
V
I--
A
S
-
SPPA
I
SGL
G
SS
A
GFDME
L
QDHAGAGH
D
A
L
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
L
D
DSPQLQ
ID
I
D
QR
KA
Q
A
L
GV
AI
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
ML
P
DD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VG
EA
APGV
S
T
G
T
A
MDIMESLVKQ
L
-
-
P
N
G
FGLE
W
T
A
--
MS
YQ
ER
L
SGAQAPA
L
Y
A
-
I
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NEMN
Q
K-
----------
G
HDLF
EA
TLH
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
S
T
GAGSG
GQHA
VG
T
GVMGGM
IS
A
T
I
LAI
Y
FV
P
LF
F
V
LV
fig|444454.5.peg.2351
Escherichia coli O157:H7 str. EC4024 (16-1026/1037)
AI
L
L
C
L
T
G
TLA
I
FS
LPV
E
QYP
D
L
AP
P
N
V
R
V
T
A
N
YPGA
S
AQ
T
L
E
N
T
VT
Q
VIE
QN
M
TG
L
D
N
LM
Y
MSS
Q
S
SGT
G
QAS
V
TL
S
F
K
A
GT
D
PD
E
A
VQ
QVQ
NQ
LQ
S
A
MRK
LP
QAVQNQ
GV
TVR-KTGDT
---
N
I
LTI
A
FV
S
TDGSMDKQ
DI
A
D
Y
V
ASN
I
QDP
LS
RVN
GVG
D
I
DAY
G
SQY-SM
RI
W
LDP
AK
LN
SFQ
M
TAKD
V
TD
AI
ESQ
N
AQIAV
GQLGG
T
P
SVDKQALNAT
I
N
A
QSL
LQT
P
E
Q
F
RD
I
T
L
RVNQ
DG
SE
V
R
L
G
DVA
T
A
E
M
G
A
E
KYDYL
S
RF
NGK
-
P
A
S
G
LG
V
K
L
AS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQY
FP
H
G
L
E
YKVA
Y
E
TT
SF
V
KA
SI
E
D
VVKT
L
L
EAI
A
LV
F
LV
M
YLFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
S
VL
Y
A
F
G
Y
S
V
N
T
LTM
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
E
GLT
P
RE
A
TR
K
SMG
QIQ
G
AL
VGIAMV
L
S
AVF
V
PM
A
F
FG
G
TT
G
A
IYR
Q
FSIT
IVA
AM
VL
SV
L
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWF
N
QM
F
NRNAER
----
Y
EKGVA
K
I
L
HRSLRW
I
V
I
Y
V
L
LLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IE
K
YY
FTHEKDN
I
M
SVF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFNQIKEAR
V
I--
A
S
-
SPPA
I
SGL
G
SS
A
GFDME
L
QDHAGAGH
D
A
L
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
L
D
DSPQLQ
ID
I
D
QR
KA
Q
A
L
GV
AI
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
ML
P
DD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VG
EA
APGV
S
T
G
T
A
MDIMESLVKQ
L
-
-
P
N
G
FGLE
W
T
A
--
MS
YQ
ER
L
SGAQAPA
L
Y
A
-
I
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NEMN
Q
K-
----------
G
HDLF
EA
TLH
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
S
T
GAGSG
GQHA
VG
T
GVMGGM
IS
A
T
I
LAI
Y
FV
P
LF
F
V
LV
fig|444449.5.peg.1816
Escherichia coli O157:H7 str. EC4042 (16-1026/1037)
AI
L
L
C
L
T
G
TLA
I
FS
LPV
E
QYP
D
L
AP
P
N
V
R
V
T
A
N
YPGA
S
AQ
T
L
E
N
T
VT
Q
VIE
QN
M
TG
L
D
N
LM
Y
MSS
Q
S
SGT
G
QAS
V
TL
S
F
K
A
GT
D
PD
E
A
VQ
QVQ
NQ
LQ
S
A
MRK
LP
QAVQNQ
GV
TVR-KTGDT
---
N
I
LTI
A
FV
S
TDGSMDKQ
DI
A
D
Y
V
ASN
I
QDP
LS
RVN
GVG
D
I
DAY
G
SQY-SM
RI
W
LDP
AK
LN
SFQ
M
TAKD
V
TD
AI
ESQ
N
AQIAV
GQLGG
T
P
SVDKQALNAT
I
N
A
QSL
LQT
P
E
Q
F
RD
I
T
L
RVNQ
DG
SE
V
R
L
G
DVA
T
A
E
M
G
A
E
KYDYL
S
RF
NGK
-
P
A
S
G
LG
V
K
L
AS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQY
FP
H
G
L
E
YKVA
Y
E
TT
SF
V
KA
SI
E
D
VVKT
L
L
EAI
A
LV
F
LV
M
YLFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
S
VL
Y
A
F
G
Y
S
V
N
T
LTM
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
E
GLT
P
RE
A
TR
K
SMG
QIQ
G
AL
VGIAMV
L
S
AVF
V
PM
A
F
FG
G
TT
G
A
IYR
Q
FSIT
IVA
AM
VL
SV
L
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWF
N
QM
F
NRNAER
----
Y
EKGVA
K
I
L
HRSLRW
I
V
I
Y
V
L
LLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IE
K
YY
FTHEKDN
I
M
SVF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFNQIKEAR
V
I--
A
S
-
SPPA
I
SGL
G
SS
A
GFDME
L
QDHAGAGH
D
A
L
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
L
D
DSPQLQ
ID
I
D
QR
KA
Q
A
L
GV
AI
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
ML
P
DD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VG
EA
APGV
S
T
G
T
A
MDIMESLVKQ
L
-
-
P
N
G
FGLE
W
T
A
--
MS
YQ
ER
L
SGAQAPA
L
Y
A
-
I
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NEMN
Q
K-
----------
G
HDLF
EA
TLH
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
S
T
GAGSG
GQHA
VG
T
GVMGGM
IS
A
T
I
LAI
Y
FV
P
LF
F
V
LV
fig|444448.5.peg.570
Escherichia coli O157:H7 str. EC4045 (16-1026/1037)
AI
L
L
C
L
T
G
TLA
I
FS
LPV
E
QYP
D
L
AP
P
N
V
R
V
T
A
N
YPGA
S
AQ
T
L
E
N
T
VT
Q
VIE
QN
M
TG
L
D
N
LM
Y
MSS
Q
S
SGT
G
QAS
V
TL
S
F
K
A
GT
D
PD
E
A
VQ
QVQ
NQ
LQ
S
A
MRK
LP
QAVQNQ
GV
TVR-KTGDT
---
N
I
LTI
A
FV
S
TDGSMDKQ
DI
A
D
Y
V
ASN
I
QDP
LS
RVN
GVG
D
I
DAY
G
SQY-SM
RI
W
LDP
AK
LN
SFQ
M
TAKD
V
TD
AI
ESQ
N
AQIAV
GQLGG
T
P
SVDKQALNAT
I
N
A
QSL
LQT
P
E
Q
F
RD
I
T
L
RVNQ
DG
SE
V
R
L
G
DVA
T
A
E
M
G
A
E
KYDYL
S
RF
NGK
-
P
A
S
G
LG
V
K
L
AS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQY
FP
H
G
L
E
YKVA
Y
E
TT
SF
V
KA
SI
E
D
VVKT
L
L
EAI
A
LV
F
LV
M
YLFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
S
VL
Y
A
F
G
Y
S
V
N
T
LTM
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
E
GLT
P
RE
A
TR
K
SMG
QIQ
G
AL
VGIAMV
L
S
AVF
V
PM
A
F
FG
G
TT
G
A
IYR
Q
FSIT
IVA
AM
VL
SV
L
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWF
N
QM
F
NRNAER
----
Y
EKGVA
K
I
L
HRSLRW
I
V
I
Y
V
L
LLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IE
K
YY
FTHEKDN
I
M
SVF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFNQIKEAR
V
I--
A
S
-
SPPA
I
SGL
G
SS
A
GFDME
L
QDHAGAGH
D
A
L
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
L
D
DSPQLQ
ID
I
D
QR
KA
Q
A
L
GV
AI
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
ML
P
DD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VG
EA
APGV
S
T
G
T
A
MDIMESLVKQ
L
-
-
P
N
G
FGLE
W
T
A
--
MS
YQ
ER
L
SGAQAPA
L
Y
A
-
I
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NEMN
Q
K-
----------
G
HDLF
EA
TLH
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
S
T
GAGSG
GQHA
VG
T
GVMGGM
IS
A
T
I
LAI
Y
FV
P
LF
F
V
LV
fig|444453.5.peg.52
Escherichia coli O157:H7 str. EC4076 (16-1026/1037)
AI
L
L
C
L
T
G
TLA
I
FS
LPV
E
QYP
D
L
AP
P
N
V
R
V
T
A
N
YPGA
S
AQ
T
L
E
N
T
VT
Q
VIE
QN
M
TG
L
D
N
LM
Y
MSS
Q
S
SGT
G
QAS
V
TL
S
F
K
A
GT
D
PD
E
A
VQ
QVQ
NQ
LQ
S
A
MRK
LP
QAVQNQ
GV
TVR-KTGDT
---
N
I
LTI
A
FV
S
TDGSMDKQ
DI
A
D
Y
V
ASN
I
QDP
LS
RVN
GVG
D
I
DAY
G
SQY-SM
RI
W
LDP
AK
LN
SFQ
M
TAKD
V
TD
AI
ESQ
N
AQIAV
GQLGG
T
P
SVDKQALNAT
I
N
A
QSL
LQT
P
E
Q
F
RD
I
T
L
RVNQ
DG
SE
V
R
L
G
DVA
T
A
E
M
G
A
E
KYDYL
S
RF
NGK
-
P
A
S
G
LG
V
K
L
AS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQY
FP
H
G
L
E
YKVA
Y
E
TT
SF
V
KA
SI
E
D
VVKT
L
L
EAI
A
LV
F
LV
M
YLFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
S
VL
Y
A
F
G
Y
S
V
N
T
LTM
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
E
GLT
P
RE
A
TR
K
SMG
QIQ
G
AL
VGIAMV
L
S
AVF
V
PM
A
F
FG
G
TT
G
A
IYR
Q
FSIT
IVA
AM
VL
SV
L
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWF
N
QM
F
NRNAER
----
Y
EKGVA
K
I
L
HRSLRW
I
V
I
Y
V
L
LLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IE
K
YY
FTHEKDN
I
M
SVF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFNQIKEAR
V
I--
A
S
-
SPPA
I
SGL
G
SS
A
GFDME
L
QDHAGAGH
D
A
L
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
L
D
DSPQLQ
ID
I
D
QR
KA
Q
A
L
GV
AI
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
ML
P
DD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VG
EA
APGV
S
T
G
T
A
MDIMESLVKQ
L
-
-
P
N
G
FGLE
W
T
A
--
MS
YQ
ER
L
SGAQAPA
L
Y
A
-
I
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NEMN
Q
K-
----------
G
HDLF
EA
TLH
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
S
T
GAGSG
GQHA
VG
T
GVMGGM
IS
A
T
I
LAI
Y
FV
P
LF
F
V
LV
fig|444452.5.peg.1540
Escherichia coli O157:H7 str. EC4113 (16-1026/1037)
AI
L
L
C
L
T
G
TLA
I
FS
LPV
E
QYP
D
L
AP
P
N
V
R
V
T
A
N
YPGA
S
AQ
T
L
E
N
T
VT
Q
VIE
QN
M
TG
L
D
N
LM
Y
MSS
Q
S
SGT
G
QAS
V
TL
S
F
K
A
GT
D
PD
E
A
VQ
QVQ
NQ
LQ
S
A
MRK
LP
QAVQNQ
GV
TVR-KTGDT
---
N
I
LTI
A
FV
S
TDGSMDKQ
DI
A
D
Y
V
ASN
I
QDP
LS
RVN
GVG
D
I
DAY
G
SQY-SM
RI
W
LDP
AK
LN
SFQ
M
TAKD
V
TD
AI
ESQ
N
AQIAV
GQLGG
T
P
SVDKQALNAT
I
N
A
QSL
LQT
P
E
Q
F
RD
I
T
L
RVNQ
DG
SE
V
R
L
G
DVA
T
A
E
M
G
A
E
KYDYL
S
RF
NGK
-
P
A
S
G
LG
V
K
L
AS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQY
FP
H
G
L
E
YKVA
Y
E
TT
SF
V
KA
SI
E
D
VVKT
L
L
EAI
A
LV
F
LV
M
YLFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
S
VL
Y
A
F
G
Y
S
V
N
T
LTM
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
E
GLT
P
RE
A
TR
K
SMG
QIQ
G
AL
VGIAMV
L
S
AVF
V
PM
A
F
FG
G
TT
G
A
IYR
Q
FSIT
IVA
AM
VL
SV
L
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWF
N
QM
F
NRNAER
----
Y
EKGVA
K
I
L
HRSLRW
I
V
I
Y
V
L
LLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IE
K
YY
FTHEKDN
I
M
SVF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFNQIKEAR
V
I--
A
S
-
SPPA
I
SGL
G
SS
A
GFDME
L
QDHAGAGH
D
A
L
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
L
D
DSPQLQ
ID
I
D
QR
KA
Q
A
L
GV
AI
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
ML
P
DD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VG
EA
APGV
S
T
G
T
A
MDIMESLVKQ
L
-
-
P
N
G
FGLE
W
T
A
--
MS
YQ
ER
L
SGAQAPA
L
Y
A
-
I
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NEMN
Q
K-
----------
G
HDLF
EA
TLH
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
S
T
GAGSG
GQHA
VG
T
GVMGGM
IS
A
T
I
LAI
Y
FV
P
LF
F
V
LV
fig|444450.8.peg.3659
Escherichia coli O157:H7 str. EC4115 (16-1026/1037)
AI
L
L
C
L
T
G
TLA
I
FS
LPV
E
QYP
D
L
AP
P
N
V
R
V
T
A
N
YPGA
S
AQ
T
L
E
N
T
VT
Q
VIE
QN
M
TG
L
D
N
LM
Y
MSS
Q
S
SGT
G
QAS
V
TL
S
F
K
A
GT
D
PD
E
A
VQ
QVQ
NQ
LQ
S
A
MRK
LP
QAVQNQ
GV
TVR-KTGDT
---
N
I
LTI
A
FV
S
TDGSMDKQ
DI
A
D
Y
V
ASN
I
QDP
LS
RVN
GVG
D
I
DAY
G
SQY-SM
RI
W
LDP
AK
LN
SFQ
M
TAKD
V
TD
AI
ESQ
N
AQIAV
GQLGG
T
P
SVDKQALNAT
I
N
A
QSL
LQT
P
E
Q
F
RD
I
T
L
RVNQ
DG
SE
V
R
L
G
DVA
T
A
E
M
G
A
E
KYDYL
S
RF
NGK
-
P
A
S
G
LG
V
K
L
AS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQY
FP
H
G
L
E
YKVA
Y
E
TT
SF
V
KA
SI
E
D
VVKT
L
L
EAI
A
LV
F
LV
M
YLFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
S
VL
Y
A
F
G
Y
S
V
N
T
LTM
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
E
GLT
P
RE
A
TR
K
SMG
QIQ
G
AL
VGIAMV
L
S
AVF
V
PM
A
F
FG
G
TT
G
A
IYR
Q
FSIT
IVA
AM
VL
SV
L
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWF
N
QM
F
NRNAER
----
Y
EKGVA
K
I
L
HRSLRW
I
V
I
Y
V
L
LLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IE
K
YY
FTHEKDN
I
M
SVF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFNQIKEAR
V
I--
A
S
-
SPPA
I
SGL
G
SS
A
GFDME
L
QDHAGAGH
D
A
L
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
L
D
DSPQLQ
ID
I
D
QR
KA
Q
A
L
GV
AI
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
ML
P
DD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VG
EA
APGV
S
T
G
T
A
MDIMESLVKQ
L
-
-
P
N
G
FGLE
W
T
A
--
MS
YQ
ER
L
SGAQAPA
L
Y
A
-
I
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NEMN
Q
K-
----------
G
HDLF
EA
TLH
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
S
T
GAGSG
GQHA
VG
T
GVMGGM
IS
A
T
I
LAI
Y
FV
P
LF
F
V
LV
fig|444451.5.peg.1310
Escherichia coli O157:H7 str. EC4196 (16-1026/1037)
AI
L
L
C
L
T
G
TLA
I
FS
LPV
E
QYP
D
L
AP
P
N
V
R
V
T
A
N
YPGA
S
AQ
T
L
E
N
T
VT
Q
VIE
QN
M
TG
L
D
N
LM
Y
MSS
Q
S
SGT
G
QAS
V
TL
S
F
K
A
GT
D
PD
E
A
VQ
QVQ
NQ
LQ
S
A
MRK
LP
QAVQNQ
GV
TVR-KTGDT
---
N
I
LTI
A
FV
S
TDGSMDKQ
DI
A
D
Y
V
ASN
I
QDP
LS
RVN
GVG
D
I
DAY
G
SQY-SM
RI
W
LDP
AK
LN
SFQ
M
TAKD
V
TD
AI
ESQ
N
AQIAV
GQLGG
T
P
SVDKQALNAT
I
N
A
QSL
LQT
P
E
Q
F
RD
I
T
L
RVNQ
DG
SE
V
R
L
G
DVA
T
A
E
M
G
A
E
KYDYL
S
RF
NGK
-
P
A
S
G
LG
V
K
L
AS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQY
FP
H
G
L
E
YKVA
Y
E
TT
SF
V
KA
SI
E
D
VVKT
L
L
EAI
A
LV
F
LV
M
YLFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
S
VL
Y
A
F
G
Y
S
V
N
T
LTM
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
E
GLT
P
RE
A
TR
K
SMG
QIQ
G
AL
VGIAMV
L
S
AVF
V
PM
A
F
FG
G
TT
G
A
IYR
Q
FSIT
IVA
AM
VL
SV
L
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWF
N
QM
F
NRNAER
----
Y
EKGVA
K
I
L
HRSLRW
I
V
I
Y
V
L
LLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IE
K
YY
FTHEKDN
I
M
SVF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFNQIKEAR
V
I--
A
S
-
SPPA
I
SGL
G
SS
A
GFDME
L
QDHAGAGH
D
A
L
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
L
D
DSPQLQ
ID
I
D
QR
KA
Q
A
L
GV
AI
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
ML
P
DD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VG
EA
APGV
S
T
G
T
A
MDIMESLVKQ
L
-
-
P
N
G
FGLE
W
T
A
--
MS
YQ
ER
L
SGAQAPA
L
Y
A
-
I
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NEMN
Q
K-
----------
G
HDLF
EA
TLH
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
S
T
GAGSG
GQHA
VG
T
GVMGGM
IS
A
T
I
LAI
Y
FV
P
LF
F
V
LV
fig|444447.5.peg.710
Escherichia coli O157:H7 str. EC4206 (16-1026/1037)
AI
L
L
C
L
T
G
TLA
I
FS
LPV
E
QYP
D
L
AP
P
N
V
R
V
T
A
N
YPGA
S
AQ
T
L
E
N
T
VT
Q
VIE
QN
M
TG
L
D
N
LM
Y
MSS
Q
S
SGT
G
QAS
V
TL
S
F
K
A
GT
D
PD
E
A
VQ
QVQ
NQ
LQ
S
A
MRK
LP
QAVQNQ
GV
TVR-KTGDT
---
N
I
LTI
A
FV
S
TDGSMDKQ
DI
A
D
Y
V
ASN
I
QDP
LS
RVN
GVG
D
I
DAY
G
SQY-SM
RI
W
LDP
AK
LN
SFQ
M
TAKD
V
TD
AI
ESQ
N
AQIAV
GQLGG
T
P
SVDKQALNAT
I
N
A
QSL
LQT
P
E
Q
F
RD
I
T
L
RVNQ
DG
SE
V
R
L
G
DVA
T
A
E
M
G
A
E
KYDYL
S
RF
NGK
-
P
A
S
G
LG
V
K
L
AS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQY
FP
H
G
L
E
YKVA
Y
E
TT
SF
V
KA
SI
E
D
VVKT
L
L
EAI
A
LV
F
LV
M
YLFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
S
VL
Y
A
F
G
Y
S
V
N
T
LTM
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
E
GLT
P
RE
A
TR
K
SMG
QIQ
G
AL
VGIAMV
L
S
AVF
V
PM
A
F
FG
G
TT
G
A
IYR
Q
FSIT
IVA
AM
VL
SV
L
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWF
N
QM
F
NRNAER
----
Y
EKGVA
K
I
L
HRSLRW
I
V
I
Y
V
L
LLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IE
K
YY
FTHEKDN
I
M
SVF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFNQIKEAR
V
I--
A
S
-
SPPA
I
SGL
G
SS
A
GFDME
L
QDHAGAGH
D
A
L
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
L
D
DSPQLQ
ID
I
D
QR
KA
Q
A
L
GV
AI
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
ML
P
DD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VG
EA
APGV
S
T
G
T
A
MDIMESLVKQ
L
-
-
P
N
G
FGLE
W
T
A
--
MS
YQ
ER
L
SGAQAPA
L
Y
A
-
I
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NEMN
Q
K-
----------
G
HDLF
EA
TLH
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
S
T
GAGSG
GQHA
VG
T
GVMGGM
IS
A
T
I
LAI
Y
FV
P
LF
F
V
LV
fig|478004.5.peg.2971
Escherichia coli O157:H7 str. EC4401 (16-1026/1037)
AI
L
L
C
L
T
G
TLA
I
FS
LPV
E
QYP
D
L
AP
P
N
V
R
V
T
A
N
YPGA
S
AQ
T
L
E
N
T
VT
Q
VIE
QN
M
TG
L
D
N
LM
Y
MSS
Q
S
SGT
G
QAS
V
TL
S
F
K
A
GT
D
PD
E
A
VQ
QVQ
NQ
LQ
S
A
MRK
LP
QAVQNQ
GV
TVR-KTGDT
---
N
I
LTI
A
FV
S
TDGSMDKQ
DI
A
D
Y
V
ASN
I
QDP
LS
RVN
GVG
D
I
DAY
G
SQY-SM
RI
W
LDP
AK
LN
SFQ
M
TAKD
V
TD
AI
ESQ
N
AQIAV
GQLGG
T
P
SVDKQALNAT
I
N
A
QSL
LQT
P
E
Q
F
RD
I
T
L
RVNQ
DG
SE
V
R
L
G
DVA
T
A
E
M
G
A
E
KYDYL
S
RF
NGK
-
P
A
S
G
LG
V
K
L
AS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQY
FP
H
G
L
E
YKVA
Y
E
TT
SF
V
KA
SI
E
D
VVKT
L
L
EAI
A
LV
F
LV
M
YLFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
S
VL
Y
A
F
G
Y
S
V
N
T
LTM
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
E
GLT
P
RE
A
TR
K
SMG
QIQ
G
AL
VGIAMV
L
S
AVF
V
PM
A
F
FG
G
TT
G
A
IYR
Q
FSIT
IVA
AM
VL
SV
L
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWF
N
QM
F
NRNAER
----
Y
EKGVA
K
I
L
HRSLRW
I
V
I
Y
V
L
LLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IE
K
YY
FTHEKDN
I
M
SVF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFNQIKEAR
V
I--
A
S
-
SPPA
I
SGL
G
SS
A
GFDME
L
QDHAGAGH
D
A
L
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
L
D
DSPQLQ
ID
I
D
QR
KA
Q
A
L
GV
AI
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
ML
P
DD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VG
EA
APGV
S
T
G
T
A
MDIMESLVKQ
L
-
-
P
N
G
FGLE
W
T
A
--
MS
YQ
ER
L
SGAQAPA
L
Y
A
-
I
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NEMN
Q
K-
----------
G
HDLF
EA
TLH
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
S
T
GAGSG
GQHA
VG
T
GVMGGM
IS
A
T
I
LAI
Y
FV
P
LF
F
V
LV
fig|478007.5.peg.1624
Escherichia coli O157:H7 str. EC508 (16-1026/1037)
AI
L
L
C
L
T
G
TLA
I
FS
LPV
E
QYP
D
L
AP
P
N
V
R
V
T
A
N
YPGA
S
AQ
T
L
E
N
T
VT
Q
VIE
QN
M
TG
L
D
N
LM
Y
MSS
Q
S
SGT
G
QAS
V
TL
S
F
K
A
GT
D
PD
E
A
VQ
QVQ
NQ
LQ
S
A
MRK
LP
QAVQNQ
GV
TVR-KTGDT
---
N
I
LTI
A
FV
S
TDGSMDKQ
DI
A
D
Y
V
ASN
I
QDP
LS
RVN
GVG
D
I
DAY
G
SQY-SM
RI
W
LDP
AK
LN
SFQ
M
TAKD
V
TD
AI
ESQ
N
AQIAV
GQLGG
T
P
SVDKQALNAT
I
N
A
QSL
LQT
P
E
Q
F
RD
I
T
L
RVNQ
DG
SE
V
R
L
G
DVA
T
A
E
M
G
A
E
KYDYL
S
RF
NGK
-
P
A
S
G
LG
V
K
L
AS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQY
FP
H
G
L
E
YKVA
Y
E
TT
SF
V
KA
SI
E
D
VVKT
L
L
EAI
A
LV
F
LV
M
YLFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
S
VL
Y
A
F
G
Y
S
V
N
T
LTM
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
E
GLT
P
RE
A
TR
K
SMG
QIQ
G
AL
VGIAMV
L
S
AVF
V
PM
A
F
FG
G
TT
G
A
IYR
Q
FSIT
IVA
AM
VL
SV
L
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWF
N
QM
F
NRNAER
----
Y
EKGVA
K
I
L
HRSLRW
I
V
I
Y
V
L
LLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IE
K
YY
FTHEKDN
I
M
SVF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFNQIKEAR
V
I--
A
S
-
SPPA
I
SGL
G
SS
A
GFDME
L
QDHAGAGH
D
A
L
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
L
D
DSPQLQ
ID
I
D
QR
KA
Q
A
L
GV
AI
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
ML
P
DD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VG
EA
APGV
S
T
G
T
A
MDIMESLVKQ
L
-
-
P
N
G
FGLE
W
T
A
--
MS
YQ
ER
L
SGAQAPA
L
Y
A
-
I
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NEMN
Q
K-
----------
G
HDLF
EA
TLH
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
S
T
GAGSG
GQHA
VG
T
GVMGGM
IS
A
T
I
LAI
Y
FV
P
LF
F
V
LV
fig|478008.5.peg.3015
Escherichia coli O157:H7 str. EC869 (16-1026/1037)
AI
L
L
C
L
T
G
TLA
I
FS
LPV
E
QYP
D
L
AP
P
N
V
R
V
T
A
N
YPGA
S
AQ
T
L
E
N
T
VT
Q
VIE
QN
M
TG
L
D
N
LM
Y
MSS
Q
S
SGT
G
QAS
V
TL
S
F
K
A
GT
D
PD
E
A
VQ
QVQ
NQ
LQ
S
A
MRK
LP
QAVQNQ
GV
TVR-KTGDT
---
N
I
LTI
A
FV
S
TDGSMDKQ
DI
A
D
Y
V
ASN
I
QDP
LS
RVN
GVG
D
I
DAY
G
SQY-SM
RI
W
LDP
AK
LN
SFQ
M
TAKD
V
TD
AI
ESQ
N
AQIAV
GQLGG
T
P
SVDKQALNAT
I
N
A
QSL
LQT
P
E
Q
F
RD
I
T
L
RVNQ
DG
SE
V
R
L
G
DVA
T
A
E
M
G
A
E
KYDYL
S
RF
NGK
-
P
A
S
G
LG
V
K
L
AS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQY
FP
H
G
L
E
YKVA
Y
E
TT
SF
V
KA
SI
E
D
VVKT
L
L
EAI
A
LV
F
LV
M
YLFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
S
VL
Y
A
F
G
Y
S
V
N
T
LTM
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
E
GLT
P
RE
A
TR
K
SMG
QIQ
G
AL
VGIAMV
L
S
AVF
V
PM
A
F
FG
G
TT
G
A
IYR
Q
FSIT
IVA
AM
VL
SV
L
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWF
N
QM
F
NRNAER
----
Y
EKGVA
K
I
L
HRSLRW
I
V
I
Y
V
L
LLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IE
K
YY
FTHEKDN
I
M
SVF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFNQIKEAR
V
I--
A
S
-
SPPA
I
SGL
G
SS
A
GFDME
L
QDHAGAGH
D
A
L
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
L
D
DSPQLQ
ID
I
D
QR
KA
Q
A
L
GV
AI
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
ML
P
DD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VG
EA
APGV
S
T
G
T
A
MDIMESLVKQ
L
-
-
P
N
G
FGLE
W
T
A
--
MS
YQ
ER
L
SGAQAPA
L
Y
A
-
I
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NEMN
Q
K-
----------
G
HDLF
EA
TLH
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
S
T
GAGSG
GQHA
VG
T
GVMGGM
IS
A
T
I
LAI
Y
FV
P
LF
F
V
LV
fig|637388.3.peg.131
Escherichia coli O157:H7 str. FRIK2000 (16-1026/1037)
AI
L
L
C
L
T
G
TLA
I
FS
LPV
E
QYP
D
L
AP
P
N
V
R
V
T
A
N
YPGA
S
AQ
T
L
E
N
T
VT
Q
VIE
QN
M
TG
L
D
N
LM
Y
MSS
Q
S
SGT
G
QAS
V
TL
S
F
K
A
GT
D
PD
E
A
VQ
QVQ
NQ
LQ
S
A
MRK
LP
QAVQNQ
GV
TVR-KTGDT
---
N
I
LTI
A
FV
S
TDGSMDKQ
DI
A
D
Y
V
ASN
I
QDP
LS
RVN
GVG
D
I
DAY
G
SQY-SM
RI
W
LDP
AK
LN
SFQ
M
TAKD
V
TD
AI
ESQ
N
AQIAV
GQLGG
T
P
SVDKQALNAT
I
N
A
QSL
LQT
P
E
Q
F
RD
I
T
L
RVNQ
DG
SE
V
R
L
G
DVA
T
A
E
M
G
A
E
KYDYL
S
RF
NGK
-
P
A
S
G
LG
V
K
L
AS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQY
FP
H
G
L
E
YKVA
Y
E
TT
SF
V
KA
SI
E
D
VVKT
L
L
EAI
A
LV
F
LV
M
YLFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
S
VL
Y
A
F
G
Y
S
V
N
T
LTM
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
E
GLT
P
RE
A
TR
K
SMG
QIQ
G
AL
VGIAMV
L
S
AVF
V
PM
A
F
FG
G
TT
G
A
IYR
Q
FSIT
IVA
AM
VL
SV
L
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWF
N
QM
F
NRNAER
----
Y
EKGVA
K
I
L
HRSLRW
I
V
I
Y
V
L
LLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IE
K
YY
FTHEKDN
I
M
SVF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFNQIKEAR
V
I--
A
S
-
SPPA
I
SGL
G
SS
A
GFDME
L
QDHAGAGH
D
A
L
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
L
D
DSPQLQ
ID
I
D
QR
KA
Q
A
L
GV
AI
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
ML
P
DD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VG
EA
APGV
S
T
G
T
A
MDIMESLVKQ
L
-
-
P
N
G
FGLE
W
T
A
--
MS
YQ
ER
L
SGAQAPA
L
Y
A
-
I
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NEMN
Q
K-
----------
G
HDLF
EA
TLH
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
S
T
GAGSG
GQHA
VG
T
GVMGGM
IS
A
T
I
LAI
Y
FV
P
LF
F
V
LV
fig|570506.3.peg.5202
Escherichia coli O157:H7 str. FRIK966 (16-1026/1037)
AI
L
L
C
L
T
G
TLA
I
FS
LPV
E
QYP
D
L
AP
P
N
V
R
V
T
A
N
YPGA
S
AQ
T
L
E
N
T
VT
Q
VIE
QN
M
TG
L
D
N
LM
Y
MSS
Q
S
SGT
G
QAS
V
TL
S
F
K
A
GT
D
PD
E
A
VQ
QVQ
NQ
LQ
S
A
MRK
LP
QAVQNQ
GV
TVR-KTGDT
---
N
I
LTI
A
FV
S
TDGSMDKQ
DI
A
D
Y
V
ASN
I
QDP
LS
RVN
GVG
D
I
DAY
G
SQY-SM
RI
W
LDP
AK
LN
SFQ
M
TAKD
V
TD
AI
ESQ
N
AQIAV
GQLGG
T
P
SVDKQALNAT
I
N
A
QSL
LQT
P
E
Q
F
RD
I
T
L
RVNQ
DG
SE
V
R
L
G
DVA
T
A
E
M
G
A
E
KYDYL
S
RF
NGK
-
P
A
S
G
LG
V
K
L
AS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQY
FP
H
G
L
E
YKVA
Y
E
TT
SF
V
KA
SI
E
D
VVKT
L
L
EAI
A
LV
F
LV
M
YLFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
S
VL
Y
A
F
G
Y
S
V
N
T
LTM
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
E
GLT
P
RE
A
TR
K
SMG
QIQ
G
AL
VGIAMV
L
S
AVF
V
PM
A
F
FG
G
TT
G
A
IYR
Q
FSIT
IVA
AM
VL
SV
L
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWF
N
QM
F
NRNAER
----
Y
EKGVA
K
I
L
HRSLRW
I
V
I
Y
V
L
LLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IE
K
YY
FTHEKDN
I
M
SVF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFNQIKEAR
V
I--
A
S
-
SPPA
I
SGL
G
SS
A
GFDME
L
QDHAGAGH
D
A
L
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
L
D
DSPQLQ
ID
I
D
QR
KA
Q
A
L
GV
AI
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
ML
P
DD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VG
EA
APGV
S
T
G
T
A
MDIMESLVKQ
L
-
-
P
N
G
FGLE
W
T
A
--
MS
YQ
ER
L
SGAQAPA
L
Y
A
-
I
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NEMN
Q
K-
----------
G
HDLF
EA
TLH
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
S
T
GAGSG
GQHA
VG
T
GVMGGM
IS
A
T
I
LAI
Y
FV
P
LF
F
V
LV
fig|544404.4.peg.3462
Escherichia coli O157:H7 str. TW14359 (16-1026/1037)
AI
L
L
C
L
T
G
TLA
I
FS
LPV
E
QYP
D
L
AP
P
N
V
R
V
T
A
N
YPGA
S
AQ
T
L
E
N
T
VT
Q
VIE
QN
M
TG
L
D
N
LM
Y
MSS
Q
S
SGT
G
QAS
V
TL
S
F
K
A
GT
D
PD
E
A
VQ
QVQ
NQ
LQ
S
A
MRK
LP
QAVQNQ
GV
TVR-KTGDT
---
N
I
LTI
A
FV
S
TDGSMDKQ
DI
A
D
Y
V
ASN
I
QDP
LS
RVN
GVG
D
I
DAY
G
SQY-SM
RI
W
LDP
AK
LN
SFQ
M
TAKD
V
TD
AI
ESQ
N
AQIAV
GQLGG
T
P
SVDKQALNAT
I
N
A
QSL
LQT
P
E
Q
F
RD
I
T
L
RVNQ
DG
SE
V
R
L
G
DVA
T
A
E
M
G
A
E
KYDYL
S
RF
NGK
-
P
A
S
G
LG
V
K
L
AS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQY
FP
H
G
L
E
YKVA
Y
E
TT
SF
V
KA
SI
E
D
VVKT
L
L
EAI
A
LV
F
LV
M
YLFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
S
VL
Y
A
F
G
Y
S
V
N
T
LTM
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
E
GLT
P
RE
A
TR
K
SMG
QIQ
G
AL
VGIAMV
L
S
AVF
V
PM
A
F
FG
G
TT
G
A
IYR
Q
FSIT
IVA
AM
VL
SV
L
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWF
N
QM
F
NRNAER
----
Y
EKGVA
K
I
L
HRSLRW
I
V
I
Y
V
L
LLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IE
K
YY
FTHEKDN
I
M
SVF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFNQIKEAR
V
I--
A
S
-
SPPA
I
SGL
G
SS
A
GFDME
L
QDHAGAGH
D
A
L
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
L
D
DSPQLQ
ID
I
D
QR
KA
Q
A
L
GV
AI
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
ML
P
DD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VG
EA
APGV
S
T
G
T
A
MDIMESLVKQ
L
-
-
P
N
G
FGLE
W
T
A
--
MS
YQ
ER
L
SGAQAPA
L
Y
A
-
I
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NEMN
Q
K-
----------
G
HDLF
EA
TLH
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
S
T
GAGSG
GQHA
VG
T
GVMGGM
IS
A
T
I
LAI
Y
FV
P
LF
F
V
LV
fig|439855.10.peg.2775
Escherichia coli SMS-3-5 (16-1026/1037)
AI
L
L
C
L
T
G
TLA
I
FS
LPV
E
QYP
D
L
AP
P
N
V
R
V
T
A
N
YPGA
S
AQ
T
L
E
N
T
VT
Q
VIE
QN
M
TG
L
D
N
LM
Y
MSS
Q
S
SGT
G
QAS
V
TL
S
F
K
A
GT
D
PD
E
A
VQ
QVQ
NQ
LQ
S
A
MRK
LP
QAVQNQ
GV
TVR-KTGDT
---
N
I
LTI
A
FV
S
TDGSMDKQ
DI
A
D
Y
V
ASN
I
QDP
LS
RVN
GVG
D
I
DAY
G
SQY-SM
RI
W
LDP
AK
LN
SFQ
M
TAKD
V
TD
AI
ESQ
N
AQIAV
GQLGG
T
P
SVDKQALNAT
I
N
A
QSL
LQT
P
E
Q
F
RD
I
T
L
RVNQ
DG
SE
V
R
L
G
DVA
T
I
E
M
G
A
E
KYDYL
S
RF
NG
M
-
P
A
S
G
LG
V
K
L
AS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQY
FP
H
G
L
E
YKVA
Y
E
TT
SF
V
KA
SI
E
D
VVKT
L
L
EAI
A
LV
F
LV
M
YLFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
S
VL
Y
A
F
G
Y
S
V
N
T
LTM
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
E
GLT
P
RE
A
TR
K
SMG
QIQ
G
AL
VGIAMV
L
S
AVF
V
PM
A
F
FG
G
TT
G
A
IYR
Q
FSIT
IVA
AM
VL
SV
L
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWF
N
QM
F
NRNAER
----
Y
EKGVA
K
I
L
HRSLRW
I
V
I
Y
V
L
LLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IE
K
YY
FTHEKDN
I
M
SVF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFNKIKEAR
V
I--
A
S
-
SPPA
I
SGL
G
SS
A
GFDME
L
QDHAGAGH
D
A
L
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
L
D
DSPQLQ
ID
I
D
QR
KA
Q
A
L
GV
AI
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
ML
P
DD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VG
EA
APGV
S
T
G
T
A
MDIMESLVKQ
L
-
-
P
N
G
FGLE
W
T
A
--
MS
YQ
ER
L
SGAQAPA
L
Y
A
-
I
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NEMN
Q
K-
----------
G
HDLF
EA
TLH
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
S
T
GAGSG
GQHA
VG
T
GVMGGM
IS
A
T
I
LAI
Y
FV
P
LF
F
V
LV
fig|749540.3.peg.1070
Escherichia coli MS 146-1 (16-1026/1037)
AI
L
L
C
L
T
G
TLA
I
FS
LPV
E
QYP
D
L
AP
P
N
V
R
V
T
A
N
YPGA
S
AQ
T
L
E
N
T
M
T
Q
VIE
HN
M
TG
L
D
N
LM
Y
MSS
Q
S
SGT
G
QAS
V
TL
S
F
K
A
GT
D
PD
E
A
VQ
QVQ
NQ
LQ
S
A
MRK
LP
QAVQNQ
GV
TVR-KTGDT
---
N
I
LTI
A
FV
S
TDGSMDKQ
DI
A
D
Y
V
ASN
I
QDP
LS
RVN
GVG
D
I
DAY
G
SQY-SM
RI
W
LDP
AK
LN
SFQ
M
TAKD
V
TD
AI
ESQ
N
AQIAV
GQLGG
T
P
SVDKQALNAT
I
N
A
QSL
LQT
P
E
Q
F
RD
I
T
L
RVNQ
DG
SE
V
R
L
G
DVA
T
VE
M
G
A
E
KYDYL
S
RF
NGK
-
P
A
S
G
LG
V
K
L
AS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQY
FP
H
G
L
E
YKVA
Y
E
TT
SF
V
KA
SI
E
D
VVKT
L
L
EAI
A
LV
F
LV
M
YLFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
S
VL
Y
A
F
G
Y
S
V
N
T
LTM
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
E
GLT
P
RE
A
TR
K
SMG
QIQ
G
AL
VGIAMV
L
S
AVF
V
PM
A
F
FG
G
TT
G
A
IYR
Q
FSIT
IVA
AM
VL
SV
L
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWF
N
QM
F
NRNAER
----
Y
EKGVA
K
I
L
HRSLRW
I
V
I
Y
V
L
LLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IE
K
YY
FTHEKDN
I
M
SVF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFNQIKEAR
V
I--
A
S
-
SPPA
I
SGL
G
SS
A
GFDME
L
QDHAGAGH
D
A
L
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
L
D
DSPQLQ
ID
I
D
QR
KA
Q
A
L
GV
AI
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
ML
P
DD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VG
EA
APGV
S
T
G
T
A
MDIMESLVKQ
L
-
-
P
N
G
FGLE
W
T
A
--
MS
YQ
ER
L
SGAQAPA
L
Y
A
-
I
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NEMN
Q
K-
----------
G
HDLF
EA
TLH
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
S
T
GAGSG
GQHA
VG
T
GVMGGM
IS
A
T
I
LAI
Y
FV
P
LF
F
V
LV
fig|340197.3.peg.135
Escherichia coli F11 (17-1021/1040)
I
M
RPVA
TTL
L
----
M
V
A
I
L
L
A
G
IIG
Y
RA
LPV
S
AL
P
E
V
DY
P
T
I
Q
V
V
T
L
YPGA
S
PD
V
M
T
S
A
VT
A
PL
E
RQ
F
GQ
M
S
GL
K
Q
MSS
Q
S
SG-
G
ASV
ITL
Q
F
Q
L
TL
P
L
D
V
A
EQ
E
VQ
AA
IN
A
A
TNL
LP
SDLPNP
P
V
YSKVNPADP
---
P
I
MTL
A
VT
S
T--AMPMT
Q
V
E
D
M
V
ETR
V
AQK
I
S
QIS
GVG
L
V
TLS
G
GQRPAV
R
V
K
L
NA
QA
IA
ALG
L
TSES
V
RT
AI
TGA
N
VNSAK
G
S
L
--
-
-
--DGPSRAVT
L
S
A
NDQ
M
Q
S
A
EE
Y
RQ
L
I
I
AYQ-
N
G
AP
I
R
L
G
DVA
T
VE
Q
G
A
E
NSWLG
A
WA
N
K
E
-
Q
A
I
V
MN
V
Q
R
QP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TES
L
P
K
S
VK
VTVL
S
D
R
T
TN
I
RA
S
V
D
D
TQFE
L
M
M
AI
A
LV
V
M
I
I
YLFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
A
V
M
V
F
L
D
F
S
I
N
N
LT
L
M
A
L
T
I
A
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
K
GEK
P
LA
A
AL
K
GAG
E
I
G
F
TI
ISLTFS
L
I
AV
L
IP
L
L
F
MG
D
IV
G
R
LF
P
E
F
A
IT
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRAS
E
KM
F
DRIIAA
----
Y
GRGLA
KVL
NHPWLT
L
S
V
A
L
S
TLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VA
D
--
VILQDPA
V
Q
S
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQ
V
SR
T
QYQFT
L
QAT---SL
D
A
L
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
QD
KGLVAY
VNVD
RD
S
A
S
R
L
G
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
L
E
HNTEN
T
PG
L
AA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SF
N
V
PDNY
S
L
G
D
A
VQAIMDTEKT
L
N
L
P
V
D
ITTQ
F
Q
G
ST
LA
F
Q
SA
L
GS--TVW
L
I
V
-
A
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAE
R
EQ
----------
G
MSPR
EA
IYQ
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
IV
S
Q
V
L
T
L
F
TT
P
VI
Y
L
L
fig|340197.5.peg.139
Escherichia coli F11 (17-1021/1040)
I
M
RPVA
TTL
L
----
M
V
A
I
L
L
A
G
IIG
Y
RA
LPV
S
AL
P
E
V
DY
P
T
I
Q
V
V
T
L
YPGA
S
PD
V
M
T
S
A
VT
A
PL
E
RQ
F
GQ
M
S
GL
K
Q
MSS
Q
S
SG-
G
ASV
ITL
Q
F
Q
L
TL
P
L
D
V
A
EQ
E
VQ
AA
IN
A
A
TNL
LP
SDLPNP
P
V
YSKVNPADP
---
P
I
MTL
A
VT
S
T--AMPMT
Q
V
E
D
M
V
ETR
V
AQK
I
S
QIS
GVG
L
V
TLS
G
GQRPAV
R
V
K
L
NA
QA
IA
ALG
L
TSES
V
RT
AI
TGA
N
VNSAK
G
S
L
--
-
-
--DGPSRAVT
L
S
A
NDQ
M
Q
S
A
EE
Y
RQ
L
I
I
AYQ-
N
G
AP
I
R
L
G
DVA
T
VE
Q
G
A
E
NSWLG
A
WA
N
K
E
-
Q
A
I
V
MN
V
Q
R
QP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TES
L
P
K
S
VK
VTVL
S
D
R
T
TN
I
RA
S
V
D
D
TQFE
L
M
M
AI
A
LV
V
M
I
I
YLFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
A
V
M
V
F
L
D
F
S
I
N
N
LT
L
M
A
L
T
I
A
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
K
GEK
P
LA
A
AL
K
GAG
E
I
G
F
TI
ISLTFS
L
I
AV
L
IP
L
L
F
MG
D
IV
G
R
LF
P
E
F
A
IT
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRAS
E
KM
F
DRIIAA
----
Y
GRGLA
KVL
NHPWLT
L
S
V
A
L
S
TLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VA
D
--
VILQDPA
V
Q
S
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQ
V
SR
T
QYQFT
L
QAT---SL
D
A
L
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
QD
KGLVAY
VNVD
RD
S
A
S
R
L
G
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
L
E
HNTEN
T
PG
L
AA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SF
N
V
PDNY
S
L
G
D
A
VQAIMDTEKT
L
N
L
P
V
D
ITTQ
F
Q
G
ST
LA
F
Q
SA
L
GS--TVW
L
I
V
-
A
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAE
R
EQ
----------
G
MSPR
EA
IYQ
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
IV
S
Q
V
L
T
L
F
TT
P
VI
Y
L
L
fig|749550.3.peg.1588
Escherichia coli MS 200-1 (17-1021/1040)
I
M
RPVA
TTL
L
----
M
V
A
I
L
L
A
G
IIG
Y
RA
LPV
S
AL
P
E
V
DY
P
T
I
Q
V
V
T
L
YPGA
S
PD
V
M
T
S
A
VT
A
PL
E
RQ
F
GQ
M
S
GL
K
Q
MSS
Q
S
SG-
G
ASV
ITL
Q
F
Q
L
TL
P
L
D
V
A
EQ
E
VQ
AA
IN
A
A
TNL
LP
SDLPNP
P
V
YSKVNPADP
---
P
I
MTL
A
VT
S
T--AMPMT
Q
V
E
D
M
V
ETR
V
AQK
I
S
QIS
GVG
L
V
TLS
G
GQRPAV
R
V
K
L
NA
QA
IA
ALG
L
TSES
V
RT
AI
TGA
N
VNSAK
G
S
L
--
-
-
--DGPSRAVT
L
S
A
NDQ
M
Q
S
A
EE
Y
RQ
L
I
I
AYQ-
N
G
AP
I
R
L
G
DVA
T
VE
Q
G
A
E
NSWLG
A
WA
N
K
E
-
Q
A
I
V
MN
V
Q
R
QP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TES
L
P
K
S
VK
VTVL
S
D
R
T
TN
I
RA
S
V
D
D
TQFE
L
M
M
AI
A
LV
V
M
I
I
YLFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
A
V
M
V
F
L
D
F
S
I
N
N
LT
L
M
A
L
T
I
A
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
K
GEK
P
LA
A
AL
K
GAG
E
I
G
F
TI
ISLTFS
L
I
AV
L
IP
L
L
F
MG
D
IV
G
R
LF
P
E
F
A
IT
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRAS
E
KM
F
DRIIAA
----
Y
GRGLA
KVL
NHPWLT
L
S
V
A
L
S
TLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VA
D
--
VILQDPA
V
Q
S
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQ
V
SR
T
QYQFT
L
QAT---SL
D
A
L
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
QD
KGLVAY
VNVD
RD
S
A
S
R
L
G
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
L
E
HNTEN
T
PG
L
AA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SF
N
V
PDNY
S
L
G
D
A
VQAIMDTEKT
L
N
L
P
V
D
ITTQ
F
Q
G
ST
LA
F
Q
SA
L
GS--TVW
L
I
V
-
A
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAE
R
EQ
----------
G
MSPR
EA
IYQ
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
IV
S
Q
V
L
T
L
F
TT
P
VI
Y
L
L
fig|585055.6.peg.2366
Escherichia coli 55989 (17-1021/1040)
I
M
RPVA
TTL
L
----
M
V
A
I
L
L
A
G
IIG
Y
RA
LPV
S
AL
P
E
V
DY
P
T
I
Q
V
V
T
L
YPGA
S
PD
V
M
T
S
A
VT
A
PL
E
RQ
F
GQ
M
S
GL
K
Q
MSS
Q
S
SG-
G
ASV
ITL
Q
F
Q
L
TL
P
L
D
V
A
EQ
E
VQ
AA
IN
A
A
TNL
LP
SDLPNP
P
V
YSKVNPADP
---
P
I
MTL
A
VT
S
T--AMPMT
Q
V
E
D
M
V
ETR
V
AQK
I
S
QIS
GVG
L
V
TLS
G
GQRPAV
R
V
K
L
NA
QA
IA
ALG
L
TSET
V
RT
AI
TGA
N
VNSAK
G
S
L
--
-
-
--DGPSRAVT
L
S
A
NDQ
M
Q
S
A
EE
Y
RQ
L
I
I
AYQ-
N
G
AP
I
R
L
G
DVA
T
VE
Q
G
A
E
NSWLG
A
WA
N
K
E
-
Q
A
I
V
MN
V
Q
R
QP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TES
L
P
K
S
VK
VTVL
S
D
R
T
TN
I
RA
S
V
D
D
TQFE
L
M
M
AI
A
LV
V
M
I
I
YLFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
A
V
M
V
F
L
D
F
S
I
N
N
LT
L
M
A
L
T
I
A
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
K
GEK
P
LA
A
AL
K
GAG
E
I
G
F
TI
ISLTFS
L
I
AV
L
IP
L
L
F
MG
D
IV
G
R
LF
R
E
F
A
IT
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRAS
E
KM
F
DRIIAA
----
Y
GQGLA
KVL
NHPWLT
L
S
V
A
L
S
TLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VA
D
--
VILQDPA
V
Q
S
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LE
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQ
V
SR
T
QYQFT
L
QAT---SL
D
A
L
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
QD
KGLVAY
VNVD
RD
S
A
S
R
L
G
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
L
E
HNTEN
T
PG
L
AA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SF
N
V
PDNY
S
L
G
D
A
VQAIMDTEKT
L
N
L
P
V
D
ITTQ
F
Q
G
ST
LA
F
Q
SA
L
GS--TVW
L
I
V
-
A
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAE
R
EQ
----------
G
MSPR
D
A
IYQ
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
IV
S
Q
V
L
T
L
F
TT
P
VI
Y
L
L
fig|585055.8.peg.2373
Escherichia coli 55989 (17-1021/1040)
I
M
RPVA
TTL
L
----
M
V
A
I
L
L
A
G
IIG
Y
RA
LPV
S
AL
P
E
V
DY
P
T
I
Q
V
V
T
L
YPGA
S
PD
V
M
T
S
A
VT
A
PL
E
RQ
F
GQ
M
S
GL
K
Q
MSS
Q
S
SG-
G
ASV
ITL
Q
F
Q
L
TL
P
L
D
V
A
EQ
E
VQ
AA
IN
A
A
TNL
LP
SDLPNP
P
V
YSKVNPADP
---
P
I
MTL
A
VT
S
T--AMPMT
Q
V
E
D
M
V
ETR
V
AQK
I
S
QIS
GVG
L
V
TLS
G
GQRPAV
R
V
K
L
NA
QA
IA
ALG
L
TSET
V
RT
AI
TGA
N
VNSAK
G
S
L
--
-
-
--DGPSRAVT
L
S
A
NDQ
M
Q
S
A
EE
Y
RQ
L
I
I
AYQ-
N
G
AP
I
R
L
G
DVA
T
VE
Q
G
A
E
NSWLG
A
WA
N
K
E
-
Q
A
I
V
MN
V
Q
R
QP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TES
L
P
K
S
VK
VTVL
S
D
R
T
TN
I
RA
S
V
D
D
TQFE
L
M
M
AI
A
LV
V
M
I
I
YLFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
A
V
M
V
F
L
D
F
S
I
N
N
LT
L
M
A
L
T
I
A
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
K
GEK
P
LA
A
AL
K
GAG
E
I
G
F
TI
ISLTFS
L
I
AV
L
IP
L
L
F
MG
D
IV
G
R
LF
R
E
F
A
IT
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRAS
E
KM
F
DRIIAA
----
Y
GQGLA
KVL
NHPWLT
L
S
V
A
L
S
TLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VA
D
--
VILQDPA
V
Q
S
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LE
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQ
V
SR
T
QYQFT
L
QAT---SL
D
A
L
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
QD
KGLVAY
VNVD
RD
S
A
S
R
L
G
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
L
E
HNTEN
T
PG
L
AA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SF
N
V
PDNY
S
L
G
D
A
VQAIMDTEKT
L
N
L
P
V
D
ITTQ
F
Q
G
ST
LA
F
Q
SA
L
GS--TVW
L
I
V
-
A
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAE
R
EQ
----------
G
MSPR
D
A
IYQ
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
IV
S
Q
V
L
T
L
F
TT
P
VI
Y
L
L
fig|362663.8.peg.2126
Escherichia coli 536 (17-1021/1040)
I
M
RPVA
TTL
L
----
M
V
A
I
L
L
A
G
IIG
Y
RA
LPV
S
AL
P
E
V
DY
P
T
I
Q
V
V
T
L
YPGA
S
PD
V
M
T
S
A
VT
A
PL
E
RQ
F
GQ
M
S
GL
K
Q
MSS
Q
S
SG-
G
ASV
ITL
Q
F
Q
L
TL
P
L
D
V
A
EQ
E
VQ
AA
IN
A
A
TNL
LP
SDLPNP
P
V
YSKVNPADP
---
P
I
MTL
A
VT
S
T--AMPMT
Q
V
E
D
M
V
ETR
V
AQK
I
S
QIS
GVG
L
V
TLS
G
GQRPAV
R
V
K
L
NA
QA
IA
ALG
L
TSES
V
RT
AI
TGA
N
VNSAK
G
S
L
--
-
-
--DGPSRAVT
L
S
A
NDQ
M
Q
S
A
EE
Y
RQ
L
I
I
AYQ-
N
G
AP
I
R
L
G
DVA
T
VE
Q
G
A
E
NSWLG
A
WA
N
K
E
-
Q
A
I
V
MN
V
Q
R
QP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TES
L
P
K
S
VK
VTVL
S
D
R
T
TN
I
RA
S
V
D
D
TQFE
L
M
M
AI
A
LV
V
M
I
I
YLFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
A
V
M
V
F
L
D
F
S
I
N
N
LT
L
M
A
L
T
I
A
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
K
GEK
P
LA
A
AL
K
GAG
E
I
G
F
TI
ISLTFS
L
I
AV
L
IP
L
L
F
MG
D
IV
G
R
LF
R
E
F
A
IT
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRAS
E
KM
F
DRIIAA
----
Y
GRGLA
KVL
NHPWLT
L
S
V
A
L
S
TLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VA
D
--
VILQDPA
V
Q
S
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQ
V
SR
T
QYQFT
L
QAT---SL
D
A
L
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
QD
KGLVAY
VNVD
RD
S
A
S
R
L
G
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
L
E
HNTEN
T
PG
L
AA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SF
N
V
PDNY
S
L
G
D
A
VQAIMDTEKT
L
N
L
P
V
D
ITTQ
F
Q
G
ST
LA
F
Q
SA
L
GS--TVW
L
I
V
-
A
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAE
R
EQ
----------
G
MSPR
EA
IYQ
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
IV
S
Q
V
L
T
L
F
TT
P
VI
Y
L
L
fig|362663.9.peg.2131
Escherichia coli 536 (17-1021/1040)
I
M
RPVA
TTL
L
----
M
V
A
I
L
L
A
G
IIG
Y
RA
LPV
S
AL
P
E
V
DY
P
T
I
Q
V
V
T
L
YPGA
S
PD
V
M
T
S
A
VT
A
PL
E
RQ
F
GQ
M
S
GL
K
Q
MSS
Q
S
SG-
G
ASV
ITL
Q
F
Q
L
TL
P
L
D
V
A
EQ
E
VQ
AA
IN
A
A
TNL
LP
SDLPNP
P
V
YSKVNPADP
---
P
I
MTL
A
VT
S
T--AMPMT
Q
V
E
D
M
V
ETR
V
AQK
I
S
QIS
GVG
L
V
TLS
G
GQRPAV
R
V
K
L
NA
QA
IA
ALG
L
TSES
V
RT
AI
TGA
N
VNSAK
G
S
L
--
-
-
--DGPSRAVT
L
S
A
NDQ
M
Q
S
A
EE
Y
RQ
L
I
I
AYQ-
N
G
AP
I
R
L
G
DVA
T
VE
Q
G
A
E
NSWLG
A
WA
N
K
E
-
Q
A
I
V
MN
V
Q
R
QP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TES
L
P
K
S
VK
VTVL
S
D
R
T
TN
I
RA
S
V
D
D
TQFE
L
M
M
AI
A
LV
V
M
I
I
YLFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
A
V
M
V
F
L
D
F
S
I
N
N
LT
L
M
A
L
T
I
A
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
K
GEK
P
LA
A
AL
K
GAG
E
I
G
F
TI
ISLTFS
L
I
AV
L
IP
L
L
F
MG
D
IV
G
R
LF
R
E
F
A
IT
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRAS
E
KM
F
DRIIAA
----
Y
GRGLA
KVL
NHPWLT
L
S
V
A
L
S
TLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VA
D
--
VILQDPA
V
Q
S
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQ
V
SR
T
QYQFT
L
QAT---SL
D
A
L
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
QD
KGLVAY
VNVD
RD
S
A
S
R
L
G
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
L
E
HNTEN
T
PG
L
AA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SF
N
V
PDNY
S
L
G
D
A
VQAIMDTEKT
L
N
L
P
V
D
ITTQ
F
Q
G
ST
LA
F
Q
SA
L
GS--TVW
L
I
V
-
A
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAE
R
EQ
----------
G
MSPR
EA
IYQ
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
IV
S
Q
V
L
T
L
F
TT
P
VI
Y
L
L
fig|656417.3.peg.2742
Escherichia coli M605 (17-1021/1040)
I
M
RPVA
TTL
L
----
M
V
A
I
L
L
A
G
IIG
Y
RA
LPV
S
AL
P
E
V
DY
P
T
I
Q
V
V
T
L
YPGA
S
PD
V
M
T
S
A
VT
A
PL
E
RQ
F
GQ
M
S
GL
K
Q
MSS
Q
S
SG-
G
ASV
ITL
Q
F
Q
L
TL
P
L
D
V
A
EQ
E
VQ
AA
IN
A
A
TNL
LP
SDLPNP
P
V
YSKVNPADP
---
P
I
MTL
A
VT
S
T--AMPMT
Q
V
E
D
M
V
ETR
V
AQK
I
S
QIS
GVG
L
V
TLS
G
GQRPAV
R
V
K
L
NA
QA
IA
ALG
L
TSES
V
RT
AI
TGA
N
VNSAK
G
S
L
--
-
-
--DGPSRAVT
L
S
A
NDQ
M
Q
S
A
EE
Y
RQ
L
I
I
AYQ-
N
G
AP
I
R
L
G
DVA
T
VE
Q
G
A
E
NSWLG
A
WA
N
K
E
-
Q
A
I
V
MN
V
Q
R
QP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TES
L
P
K
S
VK
VTVL
S
D
R
T
TN
I
RA
S
V
D
D
TQFE
L
M
M
AI
A
LV
V
M
I
I
YLFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
A
V
M
V
F
L
D
F
S
I
N
N
LT
L
M
A
L
T
I
A
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
K
GEK
P
LA
A
AL
K
GAG
E
I
G
F
TI
ISLTFS
L
I
AV
L
IP
L
L
F
MG
D
IV
G
R
LF
R
E
F
A
IT
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRAS
E
KM
F
DRIIAA
----
Y
GRGLA
KVL
NHPWLT
L
S
V
A
L
S
TLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VA
D
--
VILQDPA
V
Q
S
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQ
V
SR
T
QYQFT
L
QAT---SL
D
A
L
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
QD
KGLVAY
VNVD
RD
S
A
S
R
L
G
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
L
E
HNTEN
T
PG
L
AA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SF
N
V
PDNY
S
L
G
D
A
VQAIMDTEKT
L
N
L
P
V
D
ITTQ
F
Q
G
ST
LA
F
Q
SA
L
GS--TVW
L
I
V
-
A
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAE
R
EQ
----------
G
MSPR
EA
IYQ
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
IV
S
Q
V
L
T
L
F
TT
P
VI
Y
L
L
fig|753642.3.peg.3016
Escherichia coli NC101 (17-1021/1040)
I
M
RPVA
TTL
L
----
M
V
A
I
L
L
A
G
IIG
Y
RA
LPV
S
AL
P
E
V
DY
P
T
I
Q
V
V
T
L
YPGA
S
PD
V
M
T
S
A
VT
A
PL
E
RQ
F
GQ
M
S
GL
K
Q
MSS
Q
S
SG-
G
ASV
ITL
Q
F
Q
L
TL
P
L
D
V
A
EQ
E
VQ
AA
IN
A
A
TNL
LP
SDLPNP
P
V
YSKVNPADP
---
P
I
MTL
A
VT
S
T--AMPMT
Q
V
E
D
M
V
ETR
V
AQK
I
S
QIS
GVG
L
V
TLS
G
GQRPAV
R
V
K
L
NA
QA
IA
ALG
L
TSES
V
RT
AI
TGA
N
VNSAK
G
S
L
--
-
-
--DGPSRAVT
L
S
A
NDQ
M
Q
S
A
EE
Y
RQ
L
I
I
AYQ-
N
G
AP
I
R
L
G
DVA
T
VE
Q
G
A
E
NSWLG
A
WA
N
K
E
-
Q
A
I
V
MN
V
Q
R
QP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TES
L
P
K
S
VK
VTVL
S
D
R
T
TN
I
RA
S
V
D
D
TQFE
L
M
M
AI
A
LV
V
M
I
I
YLFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
A
V
M
V
F
L
D
F
S
I
N
N
LT
L
M
A
L
T
I
A
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
K
GEK
P
LA
A
AL
K
GAG
E
I
G
F
TI
ISLTFS
L
I
AV
L
IP
L
L
F
MG
D
IV
G
R
LF
R
E
F
A
IT
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRAS
E
KM
F
DRIIAA
----
Y
GRGLA
KVL
NHPWLT
L
S
V
A
L
S
TLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VA
D
--
VILQDPA
V
Q
S
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQ
V
SR
T
QYQFT
L
QAT---SL
D
A
L
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
QD
KGLVAY
VNVD
RD
S
A
S
R
L
G
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
L
E
HNTEN
T
PG
L
AA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SF
N
V
PDNY
S
L
G
D
A
VQAIMDTEKT
L
N
L
P
V
D
ITTQ
F
Q
G
ST
LA
F
Q
SA
L
GS--TVW
L
I
V
-
A
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
ISII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAE
R
EQ
----------
G
MSPR
EA
IYQ
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
IV
S
Q
V
L
T
L
F
TT
P
VI
Y
L
L
fig|431946.3.peg.2048
Escherichia coli SE15 (17-1021/1040)
I
M
RPVA
TTL
L
----
M
V
A
I
L
L
A
G
IIG
Y
RA
LPV
S
AL
P
E
V
DY
P
T
I
Q
V
V
T
L
YPGA
S
PD
V
M
T
S
A
VT
A
PL
E
RQ
F
GQ
M
S
GL
K
Q
MSS
Q
S
SG-
G
ASV
ITL
Q
F
Q
L
TL
P
L
D
V
A
EQ
E
VQ
AA
IN
A
A
TNL
LP
SDLPNP
P
V
YSKVNPADP
---
P
I
MTL
A
VT
S
T--AMPMT
Q
V
E
D
M
V
ETR
V
AQK
I
S
QIS
GVG
L
V
TLS
G
GQRPAV
R
V
K
L
NA
QA
IA
ALG
L
TSES
V
RT
AI
TGA
N
VNSAK
G
S
L
--
-
-
--DGPSRAVT
L
S
A
NDQ
M
Q
S
A
EE
Y
RQ
L
I
I
AYQ-
N
G
AP
I
R
L
G
DVA
T
VE
Q
G
A
E
NSWLG
A
WA
N
K
E
-
Q
A
I
V
MN
V
Q
R
QP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TES
L
P
K
S
VK
VTVL
S
D
R
T
TN
I
RA
S
V
D
D
TQFE
L
M
M
AI
A
LV
V
M
I
I
YLFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
A
V
M
V
F
L
D
F
S
I
N
N
LT
L
M
A
L
T
I
A
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
K
GEK
P
LA
A
AL
K
GAG
E
I
G
F
TI
ISLTFS
L
I
AV
L
IP
L
L
F
MG
D
IV
G
R
LF
R
E
F
A
IT
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRAS
E
KM
F
DRIIAA
----
Y
GRGLA
KVL
NHPWLT
L
S
V
A
L
S
TLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VA
D
--
VILQDPA
V
Q
S
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQ
V
SR
T
QYQFT
L
QAT---SL
D
A
L
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
QD
KGLVAY
VNVD
RD
S
A
S
R
L
G
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
L
E
HNTEN
T
PG
L
AA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SF
N
V
PDNY
S
L
G
D
A
VQAIMDTEKT
L
N
L
P
V
D
ITTQ
F
Q
G
ST
LA
F
Q
SA
L
GS--TVW
L
I
V
-
A
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAE
R
EQ
----------
G
MSPR
EA
IYQ
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
IV
S
Q
V
L
T
L
F
TT
P
VI
Y
L
L
fig|362663.8.peg.2511
Escherichia coli 536 (16-1026/1037)
AI
L
L
C
L
T
G
TLA
I
FS
LPV
E
QYP
D
L
AP
P
N
V
R
V
T
A
N
YPGA
S
AQ
T
L
E
N
T
VT
Q
VIE
QN
M
TG
L
D
N
LM
Y
MSS
Q
S
SGT
G
QAS
V
TL
S
F
K
A
GT
D
PD
E
A
VQ
QVQ
NQ
LQ
S
A
MRK
LP
QAVQNQ
GV
TVR-KTGDT
---
N
I
LTI
A
FV
S
TDGSMDKQ
DI
A
D
Y
V
ASN
I
QDP
LS
RVN
GVG
D
I
DAY
G
SQY-SM
RI
W
LDP
AK
LN
SFQ
M
TAKD
V
TD
AI
ESQ
N
AQIAV
GQLGG
T
P
SVDKQALNAT
I
N
A
QSL
LQT
P
E
Q
F
RD
I
T
L
RVNQ
DG
SE
V
R
L
G
DVA
T
VE
M
G
A
E
KYDYL
S
RF
NGK
-
P
A
S
G
LG
V
K
L
AS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQY
FP
H
G
L
E
YKVA
Y
E
TT
SF
V
KA
SI
E
D
VVKT
L
L
EAI
A
LV
F
LV
M
YLFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
S
VL
Y
A
F
G
Y
S
V
N
T
LTM
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
E
GLT
P
RE
A
TR
K
SMG
QIQ
G
AL
VGIAMV
L
S
AVF
V
PM
A
F
FG
G
TT
G
A
IYR
Q
FSIT
IIA
AM
VL
SV
L
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWF
N
QM
F
NRNAER
----
Y
EKGVA
K
I
L
HRSLRW
I
V
I
Y
V
L
LLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IE
K
YY
FTHEKDN
I
M
SVF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
V
-
R
DSKTGTSF
AII
E
RA
TKAFNKIKEAR
V
I--
A
S
-
SPPA
I
SGL
G
SS
A
GFDME
L
QDHAGAGH
D
A
L
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
L
D
DSPQLQ
ID
I
D
QR
KA
Q
A
L
GV
AI
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
ML
P
DD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VG
EA
APGV
S
T
G
T
A
MDIMESLVKQ
L
-
-
P
N
G
FGLE
W
T
A
--
MS
YQ
ER
L
SGAQAPA
L
Y
A
-
I
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NEMN
Q
K-
----------
G
HDLF
EA
TLH
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
S
T
GAGSG
GQHA
VG
T
GVMGGM
IS
A
T
I
LAI
Y
FV
P
LF
F
V
LV
fig|362663.9.peg.2516
Escherichia coli 536 (16-1026/1037)
AI
L
L
C
L
T
G
TLA
I
FS
LPV
E
QYP
D
L
AP
P
N
V
R
V
T
A
N
YPGA
S
AQ
T
L
E
N
T
VT
Q
VIE
QN
M
TG
L
D
N
LM
Y
MSS
Q
S
SGT
G
QAS
V
TL
S
F
K
A
GT
D
PD
E
A
VQ
QVQ
NQ
LQ
S
A
MRK
LP
QAVQNQ
GV
TVR-KTGDT
---
N
I
LTI
A
FV
S
TDGSMDKQ
DI
A
D
Y
V
ASN
I
QDP
LS
RVN
GVG
D
I
DAY
G
SQY-SM
RI
W
LDP
AK
LN
SFQ
M
TAKD
V
TD
AI
ESQ
N
AQIAV
GQLGG
T
P
SVDKQALNAT
I
N
A
QSL
LQT
P
E
Q
F
RD
I
T
L
RVNQ
DG
SE
V
R
L
G
DVA
T
VE
M
G
A
E
KYDYL
S
RF
NGK
-
P
A
S
G
LG
V
K
L
AS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQY
FP
H
G
L
E
YKVA
Y
E
TT
SF
V
KA
SI
E
D
VVKT
L
L
EAI
A
LV
F
LV
M
YLFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
S
VL
Y
A
F
G
Y
S
V
N
T
LTM
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
E
GLT
P
RE
A
TR
K
SMG
QIQ
G
AL
VGIAMV
L
S
AVF
V
PM
A
F
FG
G
TT
G
A
IYR
Q
FSIT
IIA
AM
VL
SV
L
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWF
N
QM
F
NRNAER
----
Y
EKGVA
K
I
L
HRSLRW
I
V
I
Y
V
L
LLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IE
K
YY
FTHEKDN
I
M
SVF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
V
-
R
DSKTGTSF
AII
E
RA
TKAFNKIKEAR
V
I--
A
S
-
SPPA
I
SGL
G
SS
A
GFDME
L
QDHAGAGH
D
A
L
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
L
D
DSPQLQ
ID
I
D
QR
KA
Q
A
L
GV
AI
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
ML
P
DD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VG
EA
APGV
S
T
G
T
A
MDIMESLVKQ
L
-
-
P
N
G
FGLE
W
T
A
--
MS
YQ
ER
L
SGAQAPA
L
Y
A
-
I
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NEMN
Q
K-
----------
G
HDLF
EA
TLH
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
S
T
GAGSG
GQHA
VG
T
GVMGGM
IS
A
T
I
LAI
Y
FV
P
LF
F
V
LV
fig|216592.1.peg.781
Escherichia coli 042 (16-1018/1037)
AI
I
M
M
L
A
G
GLA
I
MN
LPV
A
QYP
Q
I
AP
P
T
I
T
I
S
A
T
YPGA
D
AQ
T
V
E
D
S
VT
Q
VIE
QN
M
NG
L
D
GLM
Y
MSS
T
S
DAA
G
NAS
ITL
T
FE
T
GT
S
PD
I
A
QV
QVQ
NK
LQ
L
A
MPS
LP
EAVQQQ
G
I
SVD-KSSSN
---
I
L
MVA
A
FI
S
DNGSLNQY
DI
A
D
Y
V
ASN
I
KDP
LS
RTA
GVG
S
V
QLF
G
SEY-AM
RI
W
LDP
QK
LN
KYN
L
VPSD
V
IS
Q
I
KVQ
N
NQISG
GQLGG
M
P
QAADQQLNAS
I
I
V
QTR
LQT
P
EEF
GK
I
L
L
KVQQ
DG
SQ
V
L
L
R
DVA
R
VE
L
G
A
E
DYSTV
A
RY
NGK
-
P
A
A
G
IA
I
K
L
AT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAY
FP
A
S
L
K
TVYP
YDTT
PF
I
EI
SI
Q
E
VFKT
L
V
EAI
I
LV
F
LV
M
YLFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
A
I
L
S
A
V
G
F
T
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
D
KLP
P
KE
A
TH
K
SMG
QIQ
R
AL
VGIAVV
L
S
AVF
M
PM
A
F
MS
G
AT
G
E
IYR
Q
FSIT
LIS
S
M
LL
SV
F
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARF
N
TL
F
EKSTQH
----
Y
TNSTR
S
L
L
RCTGRY
M
V
VY
L
L
ICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
L
P
S
G
A
T
MVNTTKVLQ
Q
VT
DYY
LTKEKDN
V
Q
SVF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVT
AII
Q
RA
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AEL
G
TA
S
GFDME
L
LDNGNLGH
E
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
TG
V
RP
N
G
LE
DTPMFK
VNV
N
AA
KA
E
A
M
GV
A
L
S
DI
NQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
ML
P
DN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
GS
PR
L
ERY
N
GI
P
SME
I
LG
EA
AAGK
S
T
G
D
A
MKFMADLVAK
L
-
-
P
A
G
VGYS
W
T
G
--
LS
YQ
EA
L
SSNQAPA
L
Y
A
-
I
S
L
V
V
VFL
A
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LS
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
VEMM
Q
KE
----------
G
KTPI
EA
IIE
A
ARM
R
L
RPILMT
S
LA
F
I
L
G
L
LPL
VI
S
H
GAGSG
AQNA
VG
T
GVMGGM
FA
A
T
V
LAI
Y
fig|216592.3.peg.3957
Escherichia coli 042 (16-1018/1037)
AI
I
M
M
L
A
G
GLA
I
MN
LPV
A
QYP
Q
I
AP
P
T
I
T
I
S
A
T
YPGA
D
AQ
T
V
E
D
S
VT
Q
VIE
QN
M
NG
L
D
GLM
Y
MSS
T
S
DAA
G
NAS
ITL
T
FE
T
GT
S
PD
I
A
QV
QVQ
NK
LQ
L
A
MPS
LP
EAVQQQ
G
I
SVD-KSSSN
---
I
L
MVA
A
FI
S
DNGSLNQY
DI
A
D
Y
V
ASN
I
KDP
LS
RTA
GVG
S
V
QLF
G
SEY-AM
RI
W
LDP
QK
LN
KYN
L
VPSD
V
IS
Q
I
KVQ
N
NQISG
GQLGG
M
P
QAADQQLNAS
I
I
V
QTR
LQT
P
EEF
GK
I
L
L
KVQQ
DG
SQ
V
L
L
R
DVA
R
VE
L
G
A
E
DYSTV
A
RY
NGK
-
P
A
A
G
IA
I
K
L
AT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAY
FP
A
S
L
K
TVYP
YDTT
PF
I
EI
SI
Q
E
VFKT
L
V
EAI
I
LV
F
LV
M
YLFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
A
I
L
S
A
V
G
F
T
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
D
KLP
P
KE
A
TH
K
SMG
QIQ
R
AL
VGIAVV
L
S
AVF
M
PM
A
F
MS
G
AT
G
E
IYR
Q
FSIT
LIS
S
M
LL
SV
F
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARF
N
TL
F
EKSTQH
----
Y
TNSTR
S
L
L
RCTGRY
M
V
VY
L
L
ICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
L
P
S
G
A
T
MVNTTKVLQ
Q
VT
DYY
LTKEKDN
V
Q
SVF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVT
AII
Q
RA
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AEL
G
TA
S
GFDME
L
LDNGNLGH
E
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
TG
V
RP
N
G
LE
DTPMFK
VNV
N
AA
KA
E
A
M
GV
A
L
S
DI
NQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
ML
P
DN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
GS
PR
L
ERY
N
GI
P
SME
I
LG
EA
AAGK
S
T
G
D
A
MKFMADLVAK
L
-
-
P
A
G
VGYS
W
T
G
--
LS
YQ
EA
L
SSNQAPA
L
Y
A
-
I
S
L
V
V
VFL
A
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LS
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
VEMM
Q
KE
----------
G
KTPI
EA
IIE
A
ARM
R
L
RPILMT
S
LA
F
I
L
G
L
LPL
VI
S
H
GAGSG
AQNA
VG
T
GVMGGM
FA
A
T
V
LAI
Y
fig|405955.13.peg.2260
Escherichia coli APEC O1 (17-1021/1040)
I
M
RPVA
TTL
L
----
M
V
A
I
L
L
A
G
IIG
Y
RA
LPV
S
AL
P
E
V
DY
P
T
I
Q
V
V
T
L
YPGA
S
PD
V
M
T
S
A
VT
A
PL
E
RQ
F
GQ
M
S
GL
K
Q
MSS
Q
S
SG-
G
ASV
ITL
Q
F
Q
L
TL
P
L
D
V
A
EQ
E
VQ
AA
IN
A
A
TNL
LP
SDLPNP
P
V
YSKVNPADP
---
P
I
MTL
A
VT
S
T--AMPMT
Q
V
E
D
M
V
ETR
V
AQK
I
S
QIS
GVG
L
V
TLS
G
GQRPAV
R
V
K
L
NA
QA
IA
ALG
L
TSET
V
RT
AI
TGA
N
VNSAK
G
S
L
--
-
-
--DGPSRAVT
L
S
A
NDQ
M
Q
S
A
EE
Y
RQ
L
I
I
AYQ-
N
G
AP
I
R
L
G
DVA
T
VE
Q
G
A
E
NSWLG
A
WA
N
K
E
-
Q
A
I
V
MN
V
Q
R
QP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TES
L
P
K
S
VK
VTVL
S
D
R
T
TN
I
RA
S
V
D
D
TQFE
L
M
M
AI
A
LV
V
M
I
I
YLFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
A
V
M
V
F
L
D
F
S
I
N
N
LT
L
M
A
L
T
I
A
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
K
GEK
P
LA
A
AL
K
GAG
E
I
G
F
TI
ISLTFS
L
I
AV
L
IP
L
L
F
MG
D
IV
G
R
LF
R
E
F
A
IT
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRAS
E
KM
F
DRIIAA
----
Y
GRGLA
KVL
NHPWLT
L
S
V
A
L
S
TLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VA
D
--
VILQDPA
V
Q
S
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQ
V
SR
T
QYQFT
L
QAT---SL
D
A
L
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
QD
KGLVAY
VNVD
RD
S
A
S
R
L
G
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
L
E
HNTEN
T
PG
L
AA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SF
N
V
PDNY
S
L
G
D
A
VQAIMDTEKT
L
N
L
P
V
D
ITTQ
F
Q
G
ST
LA
F
Q
SA
L
GS--TVW
L
I
V
-
A
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAE
R
EQ
----------
G
MSPR
EA
IYQ
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
IV
S
Q
V
L
T
L
F
TT
P
VI
Y
L
L
fig|405955.9.peg.1843
Escherichia coli APEC O1 (17-1021/1040)
I
M
RPVA
TTL
L
----
M
V
A
I
L
L
A
G
IIG
Y
RA
LPV
S
AL
P
E
V
DY
P
T
I
Q
V
V
T
L
YPGA
S
PD
V
M
T
S
A
VT
A
PL
E
RQ
F
GQ
M
S
GL
K
Q
MSS
Q
S
SG-
G
ASV
ITL
Q
F
Q
L
TL
P
L
D
V
A
EQ
E
VQ
AA
IN
A
A
TNL
LP
SDLPNP
P
V
YSKVNPADP
---
P
I
MTL
A
VT
S
T--AMPMT
Q
V
E
D
M
V
ETR
V
AQK
I
S
QIS
GVG
L
V
TLS
G
GQRPAV
R
V
K
L
NA
QA
IA
ALG
L
TSET
V
RT
AI
TGA
N
VNSAK
G
S
L
--
-
-
--DGPSRAVT
L
S
A
NDQ
M
Q
S
A
EE
Y
RQ
L
I
I
AYQ-
N
G
AP
I
R
L
G
DVA
T
VE
Q
G
A
E
NSWLG
A
WA
N
K
E
-
Q
A
I
V
MN
V
Q
R
QP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TES
L
P
K
S
VK
VTVL
S
D
R
T
TN
I
RA
S
V
D
D
TQFE
L
M
M
AI
A
LV
V
M
I
I
YLFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
A
V
M
V
F
L
D
F
S
I
N
N
LT
L
M
A
L
T
I
A
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
K
GEK
P
LA
A
AL
K
GAG
E
I
G
F
TI
ISLTFS
L
I
AV
L
IP
L
L
F
MG
D
IV
G
R
LF
R
E
F
A
IT
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRAS
E
KM
F
DRIIAA
----
Y
GRGLA
KVL
NHPWLT
L
S
V
A
L
S
TLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VA
D
--
VILQDPA
V
Q
S
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQ
V
SR
T
QYQFT
L
QAT---SL
D
A
L
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
QD
KGLVAY
VNVD
RD
S
A
S
R
L
G
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
L
E
HNTEN
T
PG
L
AA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SF
N
V
PDNY
S
L
G
D
A
VQAIMDTEKT
L
N
L
P
V
D
ITTQ
F
Q
G
ST
LA
F
Q
SA
L
GS--TVW
L
I
V
-
A
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAE
R
EQ
----------
G
MSPR
EA
IYQ
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
IV
S
Q
V
L
T
L
F
TT
P
VI
Y
L
L
fig|199310.1.peg.2532
Escherichia coli CFT073 (17-1021/1040)
I
M
RPVA
TTL
L
----
M
V
A
I
L
L
A
G
IIG
Y
RA
LPV
S
AL
P
E
V
DY
P
T
I
Q
V
V
T
L
YPGA
S
PD
V
M
T
S
A
VT
A
PL
E
RQ
F
GQ
M
S
GL
K
Q
MSS
Q
S
SG-
G
ASV
ITL
Q
F
Q
L
TL
P
L
D
V
A
EQ
E
VQ
AA
IN
A
A
TNL
LP
SDLPNP
P
V
YSKVNPADP
---
P
I
MTL
A
VT
S
T--AMPMT
Q
V
E
D
M
V
ETR
V
AQK
I
S
QIS
GVG
L
V
TLS
G
GQRPAV
R
V
K
L
NA
QA
IA
ALG
L
TSET
V
RT
AI
TGA
N
VNSAK
G
S
L
--
-
-
--DGPSRAVT
L
S
A
NDQ
M
Q
S
A
EE
Y
RQ
L
I
I
AYQ-
N
G
AP
I
R
L
G
DVA
T
VE
Q
G
A
E
NSWLG
A
WA
N
K
E
-
Q
A
I
V
MN
V
Q
R
QP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TES
L
P
K
S
VK
VTVL
S
D
R
T
TN
I
RA
S
V
D
D
TQFE
L
M
M
AI
A
LV
V
M
I
I
YLFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
A
V
M
V
F
L
D
F
S
I
N
N
LT
L
M
A
L
T
I
A
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
K
GEK
P
LA
A
AL
K
GAG
E
I
G
F
TI
ISLTFS
L
I
AV
L
IP
L
L
F
MG
D
IV
G
R
LF
R
E
F
A
IT
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRAS
E
KM
F
DRIIAA
----
Y
GRGLA
KVL
NHPWLT
L
S
V
A
L
S
TLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VA
D
--
VILQDPA
V
Q
S
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQ
V
SR
T
QYQFT
L
QAT---SL
D
A
L
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
QD
KGLVAY
VNVD
RD
S
A
S
R
L
G
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
L
E
HNTEN
T
PG
L
AA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SF
N
V
PDNY
S
L
G
D
A
VQAIMDTEKT
L
N
L
P
V
D
ITTQ
F
Q
G
ST
LA
F
Q
SA
L
GS--TVW
L
I
V
-
A
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAE
R
EQ
----------
G
MSPR
EA
IYQ
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
IV
S
Q
V
L
T
L
F
TT
P
VI
Y
L
L
fig|199310.4.peg.2446
Escherichia coli CFT073 (17-1021/1040)
I
M
RPVA
TTL
L
----
M
V
A
I
L
L
A
G
IIG
Y
RA
LPV
S
AL
P
E
V
DY
P
T
I
Q
V
V
T
L
YPGA
S
PD
V
M
T
S
A
VT
A
PL
E
RQ
F
GQ
M
S
GL
K
Q
MSS
Q
S
SG-
G
ASV
ITL
Q
F
Q
L
TL
P
L
D
V
A
EQ
E
VQ
AA
IN
A
A
TNL
LP
SDLPNP
P
V
YSKVNPADP
---
P
I
MTL
A
VT
S
T--AMPMT
Q
V
E
D
M
V
ETR
V
AQK
I
S
QIS
GVG
L
V
TLS
G
GQRPAV
R
V
K
L
NA
QA
IA
ALG
L
TSET
V
RT
AI
TGA
N
VNSAK
G
S
L
--
-
-
--DGPSRAVT
L
S
A
NDQ
M
Q
S
A
EE
Y
RQ
L
I
I
AYQ-
N
G
AP
I
R
L
G
DVA
T
VE
Q
G
A
E
NSWLG
A
WA
N
K
E
-
Q
A
I
V
MN
V
Q
R
QP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TES
L
P
K
S
VK
VTVL
S
D
R
T
TN
I
RA
S
V
D
D
TQFE
L
M
M
AI
A
LV
V
M
I
I
YLFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
A
V
M
V
F
L
D
F
S
I
N
N
LT
L
M
A
L
T
I
A
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
K
GEK
P
LA
A
AL
K
GAG
E
I
G
F
TI
ISLTFS
L
I
AV
L
IP
L
L
F
MG
D
IV
G
R
LF
R
E
F
A
IT
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRAS
E
KM
F
DRIIAA
----
Y
GRGLA
KVL
NHPWLT
L
S
V
A
L
S
TLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VA
D
--
VILQDPA
V
Q
S
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQ
V
SR
T
QYQFT
L
QAT---SL
D
A
L
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
QD
KGLVAY
VNVD
RD
S
A
S
R
L
G
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
L
E
HNTEN
T
PG
L
AA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SF
N
V
PDNY
S
L
G
D
A
VQAIMDTEKT
L
N
L
P
V
D
ITTQ
F
Q
G
ST
LA
F
Q
SA
L
GS--TVW
L
I
V
-
A
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAE
R
EQ
----------
G
MSPR
EA
IYQ
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
IV
S
Q
V
L
T
L
F
TT
P
VI
Y
L
L
fig|714962.3.peg.2348
Escherichia coli IHE3034 (17-1021/1040)
I
M
RPVA
TTL
L
----
M
V
A
I
L
L
A
G
IIG
Y
RA
LPV
S
AL
P
E
V
DY
P
T
I
Q
V
V
T
L
YPGA
S
PD
V
M
T
S
A
VT
A
PL
E
RQ
F
GQ
M
S
GL
K
Q
MSS
Q
S
SG-
G
ASV
ITL
Q
F
Q
L
TL
P
L
D
V
A
EQ
E
VQ
AA
IN
A
A
TNL
LP
SDLPNP
P
V
YSKVNPADP
---
P
I
MTL
A
VT
S
T--AMPMT
Q
V
E
D
M
V
ETR
V
AQK
I
S
QIS
GVG
L
V
TLS
G
GQRPAV
R
V
K
L
NA
QA
IA
ALG
L
TSET
V
RT
AI
TGA
N
VNSAK
G
S
L
--
-
-
--DGPSRAVT
L
S
A
NDQ
M
Q
S
A
EE
Y
RQ
L
I
I
AYQ-
N
G
AP
I
R
L
G
DVA
T
VE
Q
G
A
E
NSWLG
A
WA
N
K
E
-
Q
A
I
V
MN
V
Q
R
QP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TES
L
P
K
S
VK
VTVL
S
D
R
T
TN
I
RA
S
V
D
D
TQFE
L
M
M
AI
A
LV
V
M
I
I
YLFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
A
V
M
V
F
L
D
F
S
I
N
N
LT
L
M
A
L
T
I
A
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
K
GEK
P
LA
A
AL
K
GAG
E
I
G
F
TI
ISLTFS
L
I
AV
L
IP
L
L
F
MG
D
IV
G
R
LF
R
E
F
A
IT
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRAS
E
KM
F
DRIIAA
----
Y
GRGLA
KVL
NHPWLT
L
S
V
A
L
S
TLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VA
D
--
VILQDPA
V
Q
S
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQ
V
SR
T
QYQFT
L
QAT---SL
D
A
L
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
QD
KGLVAY
VNVD
RD
S
A
S
R
L
G
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
L
E
HNTEN
T
PG
L
AA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SF
N
V
PDNY
S
L
G
D
A
VQAIMDTEKT
L
N
L
P
V
D
ITTQ
F
Q
G
ST
LA
F
Q
SA
L
GS--TVW
L
I
V
-
A
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAE
R
EQ
----------
G
MSPR
EA
IYQ
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
IV
S
Q
V
L
T
L
F
TT
P
VI
Y
L
L
fig|749546.3.peg.2833
Escherichia coli MS 185-1 (17-1021/1040)
I
M
RPVA
TTL
L
----
M
V
A
I
L
L
A
G
IIG
Y
RA
LPV
S
AL
P
E
V
DY
P
T
I
Q
V
V
T
L
YPGA
S
PD
V
M
T
S
A
VT
A
PL
E
RQ
F
GQ
M
S
GL
K
Q
MSS
Q
S
SG-
G
ASV
ITL
Q
F
Q
L
TL
P
L
D
V
A
EQ
E
VQ
AA
IN
A
A
TNL
LP
SDLPNP
P
V
YSKVNPADP
---
P
I
MTL
A
VT
S
T--AMPMT
Q
V
E
D
M
V
ETR
V
AQK
I
S
QIS
GVG
L
V
TLS
G
GQRPAV
R
V
K
L
NA
QA
IA
ALG
L
TSET
V
RT
AI
TGA
N
VNSAK
G
S
L
--
-
-
--DGPSRAVT
L
S
A
NDQ
M
Q
S
A
EE
Y
RQ
L
I
I
AYQ-
N
G
AP
I
R
L
G
DVA
T
VE
Q
G
A
E
NSWLG
A
WA
N
K
E
-
Q
A
I
V
MN
V
Q
R
QP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TES
L
P
K
S
VK
VTVL
S
D
R
T
TN
I
RA
S
V
D
D
TQFE
L
M
M
AI
A
LV
V
M
I
I
YLFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
A
V
M
V
F
L
D
F
S
I
N
N
LT
L
M
A
L
T
I
A
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
K
GEK
P
LA
A
AL
K
GAG
E
I
G
F
TI
ISLTFS
L
I
AV
L
IP
L
L
F
MG
D
IV
G
R
LF
R
E
F
A
IT
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRAS
E
KM
F
DRIIAA
----
Y
GRGLA
KVL
NHPWLT
L
S
V
A
L
S
TLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VA
D
--
VILQDPA
V
Q
S
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQ
V
SR
T
QYQFT
L
QAT---SL
D
A
L
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
QD
KGLVAY
VNVD
RD
S
A
S
R
L
G
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
L
E
HNTEN
T
PG
L
AA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SF
N
V
PDNY
S
L
G
D
A
VQAIMDTEKT
L
N
L
P
V
D
ITTQ
F
Q
G
ST
LA
F
Q
SA
L
GS--TVW
L
I
V
-
A
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAE
R
EQ
----------
G
MSPR
EA
IYQ
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
IV
S
Q
V
L
T
L
F
TT
P
VI
Y
L
L
fig|749527.3.peg.1512
Escherichia coli MS 21-1 (17-1021/1040)
I
M
RPVA
TTL
L
----
M
V
A
I
L
L
A
G
IIG
Y
RA
LPV
S
AL
P
E
V
DY
P
T
I
Q
V
V
T
L
YPGA
S
PD
V
M
T
S
A
VT
A
PL
E
RQ
F
GQ
M
S
GL
K
Q
MSS
Q
S
SG-
G
ASV
ITL
Q
F
Q
L
TL
P
L
D
V
A
EQ
E
VQ
AA
IN
A
A
TNL
LP
SDLPNP
P
V
YSKVNPADP
---
P
I
MTL
A
VT
S
T--AMPMT
Q
V
E
D
M
V
ETR
V
AQK
I
S
QIS
GVG
L
V
TLS
G
GQRPAV
R
V
K
L
NA
QA
IA
ALG
L
TSET
V
RT
AI
TGA
N
VNSAK
G
S
L
--
-
-
--DGPSRAVT
L
S
A
NDQ
M
Q
S
A
EE
Y
RQ
L
I
I
AYQ-
N
G
AP
I
R
L
G
DVA
T
VE
Q
G
A
E
NSWLG
A
WA
N
K
E
-
Q
A
I
V
MN
V
Q
R
QP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TES
L
P
K
S
VK
VTVL
S
D
R
T
TN
I
RA
S
V
D
D
TQFE
L
M
M
AI
A
LV
V
M
I
I
YLFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
A
V
M
V
F
L
D
F
S
I
N
N
LT
L
M
A
L
T
I
A
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
K
GEK
P
LA
A
AL
K
GAG
E
I
G
F
TI
ISLTFS
L
I
AV
L
IP
L
L
F
MG
D
IV
G
R
LF
R
E
F
A
IT
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRAS
E
KM
F
DRIIAA
----
Y
GRGLA
KVL
NHPWLT
L
S
V
A
L
S
TLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VA
D
--
VILQDPA
V
Q
S
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQ
V
SR
T
QYQFT
L
QAT---SL
D
A
L
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
QD
KGLVAY
VNVD
RD
S
A
S
R
L
G
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
L
E
HNTEN
T
PG
L
AA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SF
N
V
PDNY
S
L
G
D
A
VQAIMDTEKT
L
N
L
P
V
D
ITTQ
F
Q
G
ST
LA
F
Q
SA
L
GS--TVW
L
I
V
-
A
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAE
R
EQ
----------
G
MSPR
EA
IYQ
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
IV
S
Q
V
L
T
L
F
TT
P
VI
Y
L
L
fig|749531.3.peg.2069
Escherichia coli MS 69-1 (17-1021/1040)
I
M
RPVA
TTL
L
----
M
V
A
I
L
L
A
G
IIG
Y
RA
LPV
S
AL
P
E
V
DY
P
T
I
Q
V
V
T
L
YPGA
S
PD
V
M
T
S
A
VT
A
PL
E
RQ
F
GQ
M
S
GL
K
Q
MSS
Q
S
SG-
G
ASV
ITL
Q
F
Q
L
TL
P
L
D
V
A
EQ
E
VQ
AA
IN
A
A
TNL
LP
SDLPNP
P
V
YSKVNPADP
---
P
I
MTL
A
VT
S
T--AMPMT
Q
V
E
D
M
V
ETR
V
AQK
I
S
QIS
GVG
L
V
TLS
G
GQRPAV
R
V
K
L
NA
QA
IA
ALG
L
TSET
V
RT
AI
TGA
N
VNSAK
G
S
L
--
-
-
--DGPSRAVT
L
S
A
NDQ
M
Q
S
A
EE
Y
RQ
L
I
I
AYQ-
N
G
AP
I
R
L
G
DVA
T
VE
Q
G
A
E
NSWLG
A
WA
N
K
E
-
Q
A
I
V
MN
V
Q
R
QP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TES
L
P
K
S
VK
VTVL
S
D
R
T
TN
I
RA
S
V
D
D
TQFE
L
M
M
AI
A
LV
V
M
I
I
YLFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
A
V
M
V
F
L
D
F
S
I
N
N
LT
L
M
A
L
T
I
A
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
K
GEK
P
LA
A
AL
K
GAG
E
I
G
F
TI
ISLTFS
L
I
AV
L
IP
L
L
F
MG
D
IV
G
R
LF
R
E
F
A
IT
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRAS
E
KM
F
DRIIAA
----
Y
GRGLA
KVL
NHPWLT
L
S
V
A
L
S
TLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VA
D
--
VILQDPA
V
Q
S
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQ
V
SR
T
QYQFT
L
QAT---SL
D
A
L
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
QD
KGLVAY
VNVD
RD
S
A
S
R
L
G
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
L
E
HNTEN
T
PG
L
AA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SF
N
V
PDNY
S
L
G
D
A
VQAIMDTEKT
L
N
L
P
V
D
ITTQ
F
Q
G
ST
LA
F
Q
SA
L
GS--TVW
L
I
V
-
A
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAE
R
EQ
----------
G
MSPR
EA
IYQ
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
IV
S
Q
V
L
T
L
F
TT
P
VI
Y
L
L
fig|585035.6.peg.2154
Escherichia coli S88 (17-1021/1040)
I
M
RPVA
TTL
L
----
M
V
A
I
L
L
A
G
IIG
Y
RA
LPV
S
AL
P
E
V
DY
P
T
I
Q
V
V
T
L
YPGA
S
PD
V
M
T
S
A
VT
A
PL
E
RQ
F
GQ
M
S
GL
K
Q
MSS
Q
S
SG-
G
ASV
ITL
Q
F
Q
L
TL
P
L
D
V
A
EQ
E
VQ
AA
IN
A
A
TNL
LP
SDLPNP
P
V
YSKVNPADP
---
P
I
MTL
A
VT
S
T--AMPMT
Q
V
E
D
M
V
ETR
V
AQK
I
S
QIS
GVG
L
V
TLS
G
GQRPAV
R
V
K
L
NA
QA
IA
ALG
L
TSET
V
RT
AI
TGA
N
VNSAK
G
S
L
--
-
-
--DGPSRAVT
L
S
A
NDQ
M
Q
S
A
EE
Y
RQ
L
I
I
AYQ-
N
G
AP
I
R
L
G
DVA
T
VE
Q
G
A
E
NSWLG
A
WA
N
K
E
-
Q
A
I
V
MN
V
Q
R
QP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TES
L
P
K
S
VK
VTVL
S
D
R
T
TN
I
RA
S
V
D
D
TQFE
L
M
M
AI
A
LV
V
M
I
I
YLFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
A
V
M
V
F
L
D
F
S
I
N
N
LT
L
M
A
L
T
I
A
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
K
GEK
P
LA
A
AL
K
GAG
E
I
G
F
TI
ISLTFS
L
I
AV
L
IP
L
L
F
MG
D
IV
G
R
LF
R
E
F
A
IT
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRAS
E
KM
F
DRIIAA
----
Y
GRGLA
KVL
NHPWLT
L
S
V
A
L
S
TLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VA
D
--
VILQDPA
V
Q
S
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQ
V
SR
T
QYQFT
L
QAT---SL
D
A
L
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
QD
KGLVAY
VNVD
RD
S
A
S
R
L
G
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
L
E
HNTEN
T
PG
L
AA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SF
N
V
PDNY
S
L
G
D
A
VQAIMDTEKT
L
N
L
P
V
D
ITTQ
F
Q
G
ST
LA
F
Q
SA
L
GS--TVW
L
I
V
-
A
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAE
R
EQ
----------
G
MSPR
EA
IYQ
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
IV
S
Q
V
L
T
L
F
TT
P
VI
Y
L
L
fig|439855.10.peg.1143
Escherichia coli SMS-3-5 (17-1021/1040)
I
M
RPVA
TTL
L
----
M
V
A
I
L
L
A
G
IIG
Y
RA
LPV
S
AL
P
E
V
DY
P
T
I
Q
V
V
T
L
YPGA
S
PD
V
M
T
S
A
VT
A
PL
E
RQ
F
GQ
M
S
GL
K
Q
MSS
Q
S
SG-
G
ASV
ITL
Q
F
Q
L
TL
P
L
D
V
A
EQ
E
VQ
AA
IN
A
A
TNL
LP
SDLPNP
P
V
YSKVNPADP
---
P
I
MTL
A
VT
S
T--AMPMT
Q
V
E
D
M
V
ETR
V
AQK
I
S
QIS
GVG
L
V
TLS
G
GQRPAV
R
V
K
L
NA
QA
IA
ALG
L
TSET
V
RT
AI
TGA
N
VNSAK
G
S
L
--
-
-
--DGPSRAVT
L
S
A
NDQ
M
Q
S
A
EE
Y
RQ
L
I
I
AYQ-
N
G
AP
I
R
L
G
DVA
T
VE
Q
G
A
E
NSWLG
A
WA
N
K
E
-
Q
A
I
V
MN
V
Q
R
QP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TES
L
P
K
S
VK
VTVL
S
D
R
T
TN
I
RA
S
V
D
D
TQFE
L
M
M
AI
A
LV
V
M
I
I
YLFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
A
V
M
V
F
L
D
F
S
I
N
N
LT
L
M
A
L
T
I
A
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
K
GEK
P
LA
A
AL
K
GAG
E
I
G
F
TI
ISLTFS
L
I
AV
L
IP
L
L
F
MG
D
IV
G
R
LF
R
E
F
A
IT
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRAS
E
KM
F
DRIIAA
----
Y
GRGLA
KVL
NHPWLT
L
S
V
A
L
S
TLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VA
D
--
VILQDPA
V
Q
S
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQ
V
SR
T
QYQFT
L
QAT---SL
D
A
L
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
QD
KGLVAY
VNVD
RD
S
A
S
R
L
G
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
L
E
HNTEN
T
PG
L
AA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SF
N
V
PDNY
S
L
G
D
A
VQAIMDTEKT
L
N
L
P
V
D
ITTQ
F
Q
G
ST
LA
F
Q
SA
L
GS--TVW
L
I
V
-
A
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAE
R
EQ
----------
G
MSPR
EA
IYQ
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
IV
S
Q
V
L
T
L
F
TT
P
VI
Y
L
L
fig|656440.3.peg.2059
Escherichia coli TA206 (17-1021/1040)
I
M
RPVA
TTL
L
----
M
V
A
I
L
L
A
G
IIG
Y
RA
LPV
S
AL
P
E
V
DY
P
T
I
Q
V
V
T
L
YPGA
S
PD
V
M
T
S
A
VT
A
PL
E
RQ
F
GQ
M
S
GL
K
Q
MSS
Q
S
SG-
G
ASV
ITL
Q
F
Q
L
TL
P
L
D
V
A
EQ
E
VQ
AA
IN
A
A
TNL
LP
SDLPNP
P
V
YSKVNPADP
---
P
I
MTL
A
VT
S
T--AMPMT
Q
V
E
D
M
V
ETR
V
AQK
I
S
QIS
GVG
L
V
TLS
G
GQRPAV
R
V
K
L
NA
QA
IA
ALG
L
TSET
V
RT
AI
TGA
N
VNSAK
G
S
L
--
-
-
--DGPSRAVT
L
S
A
NDQ
M
Q
S
A
EE
Y
RQ
L
I
I
AYQ-
N
G
AP
I
R
L
G
DVA
T
VE
Q
G
A
E
NSWLG
A
WA
N
K
E
-
Q
A
I
V
MN
V
Q
R
QP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TES
L
P
K
S
VK
VTVL
S
D
R
T
TN
I
RA
S
V
D
D
TQFE
L
M
M
AI
A
LV
V
M
I
I
YLFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
A
V
M
V
F
L
D
F
S
I
N
N
LT
L
M
A
L
T
I
A
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
K
GEK
P
LA
A
AL
K
GAG
E
I
G
F
TI
ISLTFS
L
I
AV
L
IP
L
L
F
MG
D
IV
G
R
LF
R
E
F
A
IT
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRAS
E
KM
F
DRIIAA
----
Y
GRGLA
KVL
NHPWLT
L
S
V
A
L
S
TLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VA
D
--
VILQDPA
V
Q
S
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQ
V
SR
T
QYQFT
L
QAT---SL
D
A
L
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
QD
KGLVAY
VNVD
RD
S
A
S
R
L
G
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
L
E
HNTEN
T
PG
L
AA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SF
N
V
PDNY
S
L
G
D
A
VQAIMDTEKT
L
N
L
P
V
D
ITTQ
F
Q
G
ST
LA
F
Q
SA
L
GS--TVW
L
I
V
-
A
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAE
R
EQ
----------
G
MSPR
EA
IYQ
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
IV
S
Q
V
L
T
L
F
TT
P
VI
Y
L
L
fig|869729.3.peg.1363
Escherichia coli UM146 (17-1021/1040)
I
M
RPVA
TTL
L
----
M
V
A
I
L
L
A
G
IIG
Y
RA
LPV
S
AL
P
E
V
DY
P
T
I
Q
V
V
T
L
YPGA
S
PD
V
M
T
S
A
VT
A
PL
E
RQ
F
GQ
M
S
GL
K
Q
MSS
Q
S
SG-
G
ASV
ITL
Q
F
Q
L
TL
P
L
D
V
A
EQ
E
VQ
AA
IN
A
A
TNL
LP
SDLPNP
P
V
YSKVNPADP
---
P
I
MTL
A
VT
S
T--AMPMT
Q
V
E
D
M
V
ETR
V
AQK
I
S
QIS
GVG
L
V
TLS
G
GQRPAV
R
V
K
L
NA
QA
IA
ALG
L
TSET
V
RT
AI
TGA
N
VNSAK
G
S
L
--
-
-
--DGPSRAVT
L
S
A
NDQ
M
Q
S
A
EE
Y
RQ
L
I
I
AYQ-
N
G
AP
I
R
L
G
DVA
T
VE
Q
G
A
E
NSWLG
A
WA
N
K
E
-
Q
A
I
V
MN
V
Q
R
QP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TES
L
P
K
S
VK
VTVL
S
D
R
T
TN
I
RA
S
V
D
D
TQFE
L
M
M
AI
A
LV
V
M
I
I
YLFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
A
V
M
V
F
L
D
F
S
I
N
N
LT
L
M
A
L
T
I
A
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
K
GEK
P
LA
A
AL
K
GAG
E
I
G
F
TI
ISLTFS
L
I
AV
L
IP
L
L
F
MG
D
IV
G
R
LF
R
E
F
A
IT
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRAS
E
KM
F
DRIIAA
----
Y
GRGLA
KVL
NHPWLT
L
S
V
A
L
S
TLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VA
D
--
VILQDPA
V
Q
S
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQ
V
SR
T
QYQFT
L
QAT---SL
D
A
L
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
QD
KGLVAY
VNVD
RD
S
A
S
R
L
G
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
L
E
HNTEN
T
PG
L
AA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SF
N
V
PDNY
S
L
G
D
A
VQAIMDTEKT
L
N
L
P
V
D
ITTQ
F
Q
G
ST
LA
F
Q
SA
L
GS--TVW
L
I
V
-
A
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAE
R
EQ
----------
G
MSPR
EA
IYQ
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
IV
S
Q
V
L
T
L
F
TT
P
VI
Y
L
L
fig|364106.7.peg.2375
Escherichia coli UTI89 (17-1021/1040)
I
M
RPVA
TTL
L
----
M
V
A
I
L
L
A
G
IIG
Y
RA
LPV
S
AL
P
E
V
DY
P
T
I
Q
V
V
T
L
YPGA
S
PD
V
M
T
S
A
VT
A
PL
E
RQ
F
GQ
M
S
GL
K
Q
MSS
Q
S
SG-
G
ASV
ITL
Q
F
Q
L
TL
P
L
D
V
A
EQ
E
VQ
AA
IN
A
A
TNL
LP
SDLPNP
P
V
YSKVNPADP
---
P
I
MTL
A
VT
S
T--AMPMT
Q
V
E
D
M
V
ETR
V
AQK
I
S
QIS
GVG
L
V
TLS
G
GQRPAV
R
V
K
L
NA
QA
IA
ALG
L
TSET
V
RT
AI
TGA
N
VNSAK
G
S
L
--
-
-
--DGPSRAVT
L
S
A
NDQ
M
Q
S
A
EE
Y
RQ
L
I
I
AYQ-
N
G
AP
I
R
L
G
DVA
T
VE
Q
G
A
E
NSWLG
A
WA
N
K
E
-
Q
A
I
V
MN
V
Q
R
QP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TES
L
P
K
S
VK
VTVL
S
D
R
T
TN
I
RA
S
V
D
D
TQFE
L
M
M
AI
A
LV
V
M
I
I
YLFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
A
V
M
V
F
L
D
F
S
I
N
N
LT
L
M
A
L
T
I
A
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
K
GEK
P
LA
A
AL
K
GAG
E
I
G
F
TI
ISLTFS
L
I
AV
L
IP
L
L
F
MG
D
IV
G
R
LF
R
E
F
A
IT
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRAS
E
KM
F
DRIIAA
----
Y
GRGLA
KVL
NHPWLT
L
S
V
A
L
S
TLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VA
D
--
VILQDPA
V
Q
S
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQ
V
SR
T
QYQFT
L
QAT---SL
D
A
L
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
QD
KGLVAY
VNVD
RD
S
A
S
R
L
G
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
L
E
HNTEN
T
PG
L
AA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SF
N
V
PDNY
S
L
G
D
A
VQAIMDTEKT
L
N
L
P
V
D
ITTQ
F
Q
G
ST
LA
F
Q
SA
L
GS--TVW
L
I
V
-
A
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAE
R
EQ
----------
G
MSPR
EA
IYQ
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
IV
S
Q
V
L
T
L
F
TT
P
VI
Y
L
L
fig|364106.8.peg.2378
Escherichia coli UTI89 (17-1021/1040)
I
M
RPVA
TTL
L
----
M
V
A
I
L
L
A
G
IIG
Y
RA
LPV
S
AL
P
E
V
DY
P
T
I
Q
V
V
T
L
YPGA
S
PD
V
M
T
S
A
VT
A
PL
E
RQ
F
GQ
M
S
GL
K
Q
MSS
Q
S
SG-
G
ASV
ITL
Q
F
Q
L
TL
P
L
D
V
A
EQ
E
VQ
AA
IN
A
A
TNL
LP
SDLPNP
P
V
YSKVNPADP
---
P
I
MTL
A
VT
S
T--AMPMT
Q
V
E
D
M
V
ETR
V
AQK
I
S
QIS
GVG
L
V
TLS
G
GQRPAV
R
V
K
L
NA
QA
IA
ALG
L
TSET
V
RT
AI
TGA
N
VNSAK
G
S
L
--
-
-
--DGPSRAVT
L
S
A
NDQ
M
Q
S
A
EE
Y
RQ
L
I
I
AYQ-
N
G
AP
I
R
L
G
DVA
T
VE
Q
G
A
E
NSWLG
A
WA
N
K
E
-
Q
A
I
V
MN
V
Q
R
QP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TES
L
P
K
S
VK
VTVL
S
D
R
T
TN
I
RA
S
V
D
D
TQFE
L
M
M
AI
A
LV
V
M
I
I
YLFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
A
V
M
V
F
L
D
F
S
I
N
N
LT
L
M
A
L
T
I
A
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
K
GEK
P
LA
A
AL
K
GAG
E
I
G
F
TI
ISLTFS
L
I
AV
L
IP
L
L
F
MG
D
IV
G
R
LF
R
E
F
A
IT
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRAS
E
KM
F
DRIIAA
----
Y
GRGLA
KVL
NHPWLT
L
S
V
A
L
S
TLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VA
D
--
VILQDPA
V
Q
S
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQ
V
SR
T
QYQFT
L
QAT---SL
D
A
L
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
QD
KGLVAY
VNVD
RD
S
A
S
R
L
G
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
L
E
HNTEN
T
PG
L
AA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SF
N
V
PDNY
S
L
G
D
A
VQAIMDTEKT
L
N
L
P
V
D
ITTQ
F
Q
G
ST
LA
F
Q
SA
L
GS--TVW
L
I
V
-
A
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAE
R
EQ
----------
G
MSPR
EA
IYQ
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
IV
S
Q
V
L
T
L
F
TT
P
VI
Y
L
L
fig|562.376.peg.3981
Escherichia coli WV_060327 (17-1021/1040)
I
M
RPVA
TTL
L
----
M
V
A
I
L
L
A
G
IIG
Y
RA
LPV
S
AL
P
E
V
DY
P
T
I
Q
V
V
T
L
YPGA
S
PD
V
M
T
S
A
VT
A
PL
E
RQ
F
GQ
M
S
GL
K
Q
MSS
Q
S
SG-
G
ASV
ITL
Q
F
Q
L
TL
P
L
D
V
A
EQ
E
VQ
AA
IN
A
A
TNL
LP
SDLPNP
P
V
YSKVNPADP
---
P
I
MTL
A
VT
S
T--AMPMT
Q
V
E
D
M
V
ETR
V
AQK
I
S
QIS
GVG
L
V
TLS
G
GQRPAV
R
V
K
L
NA
QA
IA
ALG
L
TSET
V
RT
AI
TGA
N
VNSAK
G
S
L
--
-
-
--DGPSRAVT
L
S
A
NDQ
M
Q
S
A
EE
Y
RQ
L
I
I
AYQ-
N
G
AP
I
R
L
G
DVA
T
VE
Q
G
A
E
NSWLG
A
WA
N
K
E
-
Q
A
I
V
MN
V
Q
R
QP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TES
L
P
K
S
VK
VTVL
S
D
R
T
TN
I
RA
S
V
D
D
TQFE
L
M
M
AI
A
LV
V
M
I
I
YLFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
A
V
M
V
F
L
D
F
S
I
N
N
LT
L
M
A
L
T
I
A
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
K
GEK
P
LA
A
AL
K
GAG
E
I
G
F
TI
ISLTFS
L
I
AV
L
IP
L
L
F
MG
D
IV
G
R
LF
R
E
F
A
IT
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRAS
E
KM
F
DRIIAA
----
Y
GRGLA
KVL
NHPWLT
L
S
V
A
L
S
TLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VA
D
--
VILQDPA
V
Q
S
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQ
V
SR
T
QYQFT
L
QAT---SL
D
A
L
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
QD
KGLVAY
VNVD
RD
S
A
S
R
L
G
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
L
E
HNTEN
T
PG
L
AA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SF
N
V
PDNY
S
L
G
D
A
VQAIMDTEKT
L
N
L
P
V
D
ITTQ
F
Q
G
ST
LA
F
Q
SA
L
GS--TVW
L
I
V
-
A
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAE
R
EQ
----------
G
MSPR
EA
IYQ
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
IV
S
Q
V
L
T
L
F
TT
P
VI
Y
L
L
fig|344610.3.peg.2093
Escherichia coli 53638 (17-1021/1040)
I
M
RPVA
TTL
L
----
M
V
A
I
L
L
A
G
IIG
Y
RA
LPV
S
AL
P
E
V
DY
P
T
I
Q
V
V
T
L
YPGA
S
PD
V
M
T
S
A
VT
A
PL
E
RQ
F
GQ
M
S
GL
K
Q
MSS
Q
S
SG-
G
ASV
ITL
Q
F
Q
L
TL
P
L
D
V
A
EQ
E
VQ
AA
IN
A
A
TNL
LP
SDLPNP
P
V
YSKVNPADP
---
P
I
MTL
A
VT
S
T--AMPMT
Q
V
E
D
M
V
ETR
V
AQK
I
S
QIS
GVG
L
V
TLS
G
GQRPAV
R
V
K
L
NA
QA
IA
ALG
L
TSET
V
RT
AI
TGA
N
VNSAK
G
S
L
--
-
-
--DGPSRAVT
L
S
A
NDQ
M
Q
S
A
EE
Y
RQ
L
I
I
AYQ-
N
G
AP
I
R
L
G
DVA
T
VE
Q
G
A
E
NSWLG
A
WA
N
K
E
-
Q
A
I
V
MN
V
Q
R
QP
G
T
N
IIS
T
ADS
I
RQM
L
PQ
L
TES
L
P
K
S
VK
VTVL
S
D
R
T
TN
I
RA
S
V
D
D
TQFE
L
M
M
AI
A
LV
V
M
I
I
YLFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
A
V
M
V
F
L
D
F
S
I
N
N
LT
L
M
A
L
T
I
A
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
K
GEK
P
LA
A
AL
K
GAG
E
I
G
F
TI
ISLTFS
L
I
AV
L
IP
L
L
F
MG
D
IV
G
R
LF
R
E
F
A
IT
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRAS
E
KM
F
DRIIAA
----
Y
GRGLA
KVL
NHPWLT
L
S
V
A
L
S
TLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VA
D
--
VILQDPA
V
Q
S
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQ
V
SR
T
QYQFT
L
QAT---SL
D
A
L
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
QD
KGLVAY
VNVD
RD
S
A
S
R
L
G
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
L
E
HNTEN
T
PG
L
AA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SF
N
V
PDNY
S
L
G
D
A
VQAIMDTEKT
L
N
L
P
V
D
ITTQ
F
Q
G
ST
LA
F
Q
SA
L
GS--TVW
L
I
V
-
A
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAE
R
EQ
----------
G
MSPR
EA
IYQ
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
IV
S
Q
V
L
T
L
F
TT
P
VI
Y
L
L
fig|344610.7.peg.4398
Escherichia coli 53638 (17-1021/1040)
I
M
RPVA
TTL
L
----
M
V
A
I
L
L
A
G
IIG
Y
RA
LPV
S
AL
P
E
V
DY
P
T
I
Q
V
V
T
L
YPGA
S
PD
V
M
T
S
A
VT
A
PL
E
RQ
F
GQ
M
S
GL
K
Q
MSS
Q
S
SG-
G
ASV
ITL
Q
F
Q
L
TL
P
L
D
V
A
EQ
E
VQ
AA
IN
A
A
TNL
LP
SDLPNP
P
V
YSKVNPADP
---
P
I
MTL
A
VT
S
T--AMPMT
Q
V
E
D
M
V
ETR
V
AQK
I
S
QIS
GVG
L
V
TLS
G
GQRPAV
R
V
K
L
NA
QA
IA
ALG
L
TSET
V
RT
AI
TGA
N
VNSAK
G
S
L
--
-
-
--DGPSRAVT
L
S
A
NDQ
M
Q
S
A
EE
Y
RQ
L
I
I
AYQ-
N
G
AP
I
R
L
G
DVA
T
VE
Q
G
A
E
NSWLG
A
WA
N
K
E
-
Q
A
I
V
MN
V
Q
R
QP
G
T
N
IIS
T
ADS
I
RQM
L
PQ
L
TES
L
P
K
S
VK
VTVL
S
D
R
T
TN
I
RA
S
V
D
D
TQFE
L
M
M
AI
A
LV
V
M
I
I
YLFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
A
V
M
V
F
L
D
F
S
I
N
N
LT
L
M
A
L
T
I
A
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
K
GEK
P
LA
A
AL
K
GAG
E
I
G
F
TI
ISLTFS
L
I
AV
L
IP
L
L
F
MG
D
IV
G
R
LF
R
E
F
A
IT
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRAS
E
KM
F
DRIIAA
----
Y
GRGLA
KVL
NHPWLT
L
S
V
A
L
S
TLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VA
D
--
VILQDPA
V
Q
S
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQ
V
SR
T
QYQFT
L
QAT---SL
D
A
L
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
QD
KGLVAY
VNVD
RD
S
A
S
R
L
G
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
L
E
HNTEN
T
PG
L
AA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SF
N
V
PDNY
S
L
G
D
A
VQAIMDTEKT
L
N
L
P
V
D
ITTQ
F
Q
G
ST
LA
F
Q
SA
L
GS--TVW
L
I
V
-
A
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAE
R
EQ
----------
G
MSPR
EA
IYQ
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
IV
S
Q
V
L
T
L
F
TT
P
VI
Y
L
L
fig|585397.7.peg.2437
Escherichia coli ED1a (17-1021/1040)
I
M
RPVA
TTL
L
----
M
V
A
I
L
L
A
G
IIG
Y
RA
LPV
S
AL
P
E
V
DY
P
T
I
Q
V
V
T
L
YPGA
S
PD
V
M
T
S
A
VT
A
PL
E
RQ
F
GQ
M
S
GL
K
Q
MSS
Q
S
SG-
G
ASV
ITL
Q
F
Q
L
TL
P
L
D
V
A
EQ
E
VQ
AA
IN
A
A
TNL
LP
SDLPNP
P
V
YSKVNPADP
---
P
I
MTL
A
VT
S
T--AMPMT
Q
V
E
D
M
V
ETR
V
AQK
I
S
QIS
GVG
L
V
TLS
G
GQRPAV
R
V
K
L
NA
QA
IA
ALG
L
TSET
V
RT
AI
TGA
N
VNSAK
G
S
L
--
-
-
--DGPSRAVT
L
S
A
NDQ
M
Q
S
A
EE
Y
RQ
L
I
I
AYQ-
N
G
AP
I
R
L
G
DVA
T
VE
Q
G
A
E
NSWLG
A
WA
N
K
E
-
Q
A
I
V
MN
V
Q
R
QP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TES
L
P
K
S
VK
VTVL
S
D
R
T
TN
I
RA
S
V
D
D
TQFE
L
M
M
AI
A
LV
V
M
I
I
YLFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
A
V
M
V
F
L
D
F
S
I
N
N
LT
L
M
A
L
T
I
A
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
K
GEK
P
LA
A
AL
K
GAG
E
I
G
F
TI
ISLTFS
L
I
AV
L
IP
L
L
F
MG
D
IV
G
R
LF
R
E
F
A
IT
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRAS
E
KM
F
DRIIAA
----
Y
GRGLA
KVL
NHPWLT
L
S
V
A
L
S
TLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VA
D
--
VILQDPA
V
Q
S
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQ
V
SR
T
QYQFT
L
QAT---SL
D
A
L
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
QD
KGLVAY
VNVD
RD
S
A
S
R
L
G
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
L
E
HNTEN
T
PG
L
AA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEPRF
AP
LS
I
NHL
D
QF
P
VTT
I
SF
N
V
PDNY
S
L
G
D
A
VQAIMDTEKT
L
N
L
P
V
D
ITTQ
F
Q
G
ST
LA
F
Q
SA
L
GS--TVW
L
I
V
-
A
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAE
R
EQ
----------
G
MSPR
EA
IYQ
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
IV
S
Q
V
L
T
L
F
TT
P
VI
Y
L
L
fig|585397.9.peg.2435
Escherichia coli ED1a (17-1021/1040)
I
M
RPVA
TTL
L
----
M
V
A
I
L
L
A
G
IIG
Y
RA
LPV
S
AL
P
E
V
DY
P
T
I
Q
V
V
T
L
YPGA
S
PD
V
M
T
S
A
VT
A
PL
E
RQ
F
GQ
M
S
GL
K
Q
MSS
Q
S
SG-
G
ASV
ITL
Q
F
Q
L
TL
P
L
D
V
A
EQ
E
VQ
AA
IN
A
A
TNL
LP
SDLPNP
P
V
YSKVNPADP
---
P
I
MTL
A
VT
S
T--AMPMT
Q
V
E
D
M
V
ETR
V
AQK
I
S
QIS
GVG
L
V
TLS
G
GQRPAV
R
V
K
L
NA
QA
IA
ALG
L
TSET
V
RT
AI
TGA
N
VNSAK
G
S
L
--
-
-
--DGPSRAVT
L
S
A
NDQ
M
Q
S
A
EE
Y
RQ
L
I
I
AYQ-
N
G
AP
I
R
L
G
DVA
T
VE
Q
G
A
E
NSWLG
A
WA
N
K
E
-
Q
A
I
V
MN
V
Q
R
QP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TES
L
P
K
S
VK
VTVL
S
D
R
T
TN
I
RA
S
V
D
D
TQFE
L
M
M
AI
A
LV
V
M
I
I
YLFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
A
V
M
V
F
L
D
F
S
I
N
N
LT
L
M
A
L
T
I
A
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
K
GEK
P
LA
A
AL
K
GAG
E
I
G
F
TI
ISLTFS
L
I
AV
L
IP
L
L
F
MG
D
IV
G
R
LF
R
E
F
A
IT
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRAS
E
KM
F
DRIIAA
----
Y
GRGLA
KVL
NHPWLT
L
S
V
A
L
S
TLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VA
D
--
VILQDPA
V
Q
S
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQ
V
SR
T
QYQFT
L
QAT---SL
D
A
L
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
QD
KGLVAY
VNVD
RD
S
A
S
R
L
G
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
L
E
HNTEN
T
PG
L
AA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEPRF
AP
LS
I
NHL
D
QF
P
VTT
I
SF
N
V
PDNY
S
L
G
D
A
VQAIMDTEKT
L
N
L
P
V
D
ITTQ
F
Q
G
ST
LA
F
Q
SA
L
GS--TVW
L
I
V
-
A
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAE
R
EQ
----------
G
MSPR
EA
IYQ
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
IV
S
Q
V
L
T
L
F
TT
P
VI
Y
L
L
fig|670888.3.peg.4212
Escherichia coli 1827-70 (17-1021/1040)
I
M
RPVA
TTL
L
----
M
V
A
I
L
L
A
G
IIG
Y
RA
LPV
S
AL
P
E
V
DY
P
T
I
Q
V
V
T
L
YPGA
S
PD
V
M
T
S
A
VT
A
PL
E
RQ
F
GQ
M
S
GL
K
Q
MSS
Q
S
SG-
G
ASV
ITL
Q
F
Q
L
TL
P
L
D
V
A
EQ
E
VQ
AA
IN
A
A
TNL
LP
SDLPNP
P
V
YSKVNPADP
---
P
I
MTL
A
VT
S
T--AMPMT
Q
V
E
D
M
V
ETR
V
AQK
I
S
QIS
GVG
L
V
TLS
G
GQRPAV
R
V
K
L
NA
QA
IA
ALG
L
TSET
V
RT
AI
TGA
N
VNSAK
G
S
L
--
-
-
--DGPSRAVT
L
S
A
NDQ
M
Q
S
A
EE
Y
RQ
L
I
I
AYQ-
N
G
AP
I
R
L
G
DVA
T
VE
Q
G
A
E
NSWLG
A
WA
N
K
E
-
Q
A
I
V
MN
V
Q
R
QP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TES
L
P
K
S
VK
VTVL
S
D
R
T
TN
I
RA
S
V
D
D
TQFE
L
M
M
AI
A
LV
V
M
I
I
YLFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
A
V
M
V
F
L
D
F
S
I
N
N
LT
L
M
A
L
T
I
A
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
K
GEK
P
LA
A
AL
K
GAG
E
I
G
F
TI
ISLTFS
L
I
AV
L
IP
L
L
F
MG
D
IV
G
R
LF
R
E
F
A
IT
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRAS
E
KM
F
DRIIAA
----
Y
GRGLA
KVL
NHPWLT
L
S
V
A
L
S
TLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VA
D
--
VILQDPA
V
Q
S
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQ
V
SR
T
QYQFT
L
QAT---SL
D
A
L
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
QD
KGLVAY
VNVD
RD
S
A
S
R
L
G
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
L
E
HNTEN
T
PG
L
AA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SF
N
V
PDNY
S
L
G
D
A
VQAIMDTEKT
L
N
L
P
V
D
ITTQ
F
Q
G
ST
LA
F
Q
SA
L
GS--TVW
L
I
V
-
A
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAE
R
EQ
----------
G
MSPR
EA
IYQ
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
IV
S
Q
V
L
T
L
F
TT
P
VI
Y
L
L
fig|481805.3.peg.1678
Escherichia coli ATCC 8739 (17-1021/1040)
I
M
RPVA
TTL
L
----
M
V
A
I
L
L
A
G
IIG
Y
RA
LPV
S
AL
P
E
V
DY
P
T
I
Q
V
V
T
L
YPGA
S
PD
V
M
T
S
A
VT
A
PL
E
RQ
F
GQ
M
S
GL
K
Q
MSS
Q
S
SG-
G
ASV
ITL
Q
F
Q
L
TL
P
L
D
V
A
EQ
E
VQ
AA
IN
A
A
TNL
LP
SDLPNP
P
V
YSKVNPADP
---
P
I
MTL
A
VT
S
T--AMPMT
Q
V
E
D
M
V
ETR
V
AQK
I
S
QIS
GVG
L
V
TLS
G
GQRPAV
R
V
K
L
NA
QA
IA
ALG
L
TSET
V
RT
AI
TGA
N
VNSAK
G
S
L
--
-
-
--DGPSRAVT
L
S
A
NDQ
M
Q
S
A
EE
Y
RQ
L
I
I
AYQ-
N
G
AP
I
R
L
G
DVA
T
VE
Q
G
A
E
NSWLG
A
WA
N
K
E
-
Q
A
I
V
MN
V
Q
R
QP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TES
L
P
K
S
VK
VTVL
S
D
R
T
TN
I
RA
S
V
D
D
TQFE
L
M
M
AI
A
LV
V
M
I
I
YLFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
A
V
M
V
F
L
D
F
S
I
N
N
LT
L
M
A
L
T
I
A
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
K
GEK
P
LA
A
AL
K
GAG
E
I
G
F
TI
ISLTFS
L
I
AV
L
IP
L
L
F
MG
D
IV
G
R
LF
R
E
F
A
IT
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRAS
E
KM
F
DRIIAA
----
Y
GRGLA
KVL
NHPWLT
L
S
V
A
L
S
TLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VA
D
--
VILQDPA
V
Q
S
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQ
V
SR
T
QYQFT
L
QAT---SL
D
A
L
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
QD
KGLVAY
VNVD
RD
S
A
S
R
L
G
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
L
E
HNTEN
T
PG
L
AA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SF
N
V
PDNY
S
L
G
D
A
VQAIMDTEKT
L
N
L
P
V
D
ITTQ
F
Q
G
ST
LA
F
Q
SA
L
GS--TVW
L
I
V
-
A
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAE
R
EQ
----------
G
MSPR
EA
IYQ
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
IV
S
Q
V
L
T
L
F
TT
P
VI
Y
L
L
fig|481805.6.peg.1673
Escherichia coli ATCC 8739 (17-1021/1040)
I
M
RPVA
TTL
L
----
M
V
A
I
L
L
A
G
IIG
Y
RA
LPV
S
AL
P
E
V
DY
P
T
I
Q
V
V
T
L
YPGA
S
PD
V
M
T
S
A
VT
A
PL
E
RQ
F
GQ
M
S
GL
K
Q
MSS
Q
S
SG-
G
ASV
ITL
Q
F
Q
L
TL
P
L
D
V
A
EQ
E
VQ
AA
IN
A
A
TNL
LP
SDLPNP
P
V
YSKVNPADP
---
P
I
MTL
A
VT
S
T--AMPMT
Q
V
E
D
M
V
ETR
V
AQK
I
S
QIS
GVG
L
V
TLS
G
GQRPAV
R
V
K
L
NA
QA
IA
ALG
L
TSET
V
RT
AI
TGA
N
VNSAK
G
S
L
--
-
-
--DGPSRAVT
L
S
A
NDQ
M
Q
S
A
EE
Y
RQ
L
I
I
AYQ-
N
G
AP
I
R
L
G
DVA
T
VE
Q
G
A
E
NSWLG
A
WA
N
K
E
-
Q
A
I
V
MN
V
Q
R
QP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TES
L
P
K
S
VK
VTVL
S
D
R
T
TN
I
RA
S
V
D
D
TQFE
L
M
M
AI
A
LV
V
M
I
I
YLFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
A
V
M
V
F
L
D
F
S
I
N
N
LT
L
M
A
L
T
I
A
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
K
GEK
P
LA
A
AL
K
GAG
E
I
G
F
TI
ISLTFS
L
I
AV
L
IP
L
L
F
MG
D
IV
G
R
LF
R
E
F
A
IT
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRAS
E
KM
F
DRIIAA
----
Y
GRGLA
KVL
NHPWLT
L
S
V
A
L
S
TLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VA
D
--
VILQDPA
V
Q
S
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQ
V
SR
T
QYQFT
L
QAT---SL
D
A
L
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
QD
KGLVAY
VNVD
RD
S
A
S
R
L
G
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
L
E
HNTEN
T
PG
L
AA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SF
N
V
PDNY
S
L
G
D
A
VQAIMDTEKT
L
N
L
P
V
D
ITTQ
F
Q
G
ST
LA
F
Q
SA
L
GS--TVW
L
I
V
-
A
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAE
R
EQ
----------
G
MSPR
EA
IYQ
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
IV
S
Q
V
L
T
L
F
TT
P
VI
Y
L
L
fig|595496.3.peg.2043
Escherichia coli BW2952 (17-1021/1040)
I
M
RPVA
TTL
L
----
M
V
A
I
L
L
A
G
IIG
Y
RA
LPV
S
AL
P
E
V
DY
P
T
I
Q
V
V
T
L
YPGA
S
PD
V
M
T
S
A
VT
A
PL
E
RQ
F
GQ
M
S
GL
K
Q
MSS
Q
S
SG-
G
ASV
ITL
Q
F
Q
L
TL
P
L
D
V
A
EQ
E
VQ
AA
IN
A
A
TNL
LP
SDLPNP
P
V
YSKVNPADP
---
P
I
MTL
A
VT
S
T--AMPMT
Q
V
E
D
M
V
ETR
V
AQK
I
S
QIS
GVG
L
V
TLS
G
GQRPAV
R
V
K
L
NA
QA
IA
ALG
L
TSET
V
RT
AI
TGA
N
VNSAK
G
S
L
--
-
-
--DGPSRAVT
L
S
A
NDQ
M
Q
S
A
EE
Y
RQ
L
I
I
AYQ-
N
G
AP
I
R
L
G
DVA
T
VE
Q
G
A
E
NSWLG
A
WA
N
K
E
-
Q
A
I
V
MN
V
Q
R
QP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TES
L
P
K
S
VK
VTVL
S
D
R
T
TN
I
RA
S
V
D
D
TQFE
L
M
M
AI
A
LV
V
M
I
I
YLFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
A
V
M
V
F
L
D
F
S
I
N
N
LT
L
M
A
L
T
I
A
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
K
GEK
P
LA
A
AL
K
GAG
E
I
G
F
TI
ISLTFS
L
I
AV
L
IP
L
L
F
MG
D
IV
G
R
LF
R
E
F
A
IT
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRAS
E
KM
F
DRIIAA
----
Y
GRGLA
KVL
NHPWLT
L
S
V
A
L
S
TLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VA
D
--
VILQDPA
V
Q
S
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQ
V
SR
T
QYQFT
L
QAT---SL
D
A
L
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
QD
KGLVAY
VNVD
RD
S
A
S
R
L
G
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
L
E
HNTEN
T
PG
L
AA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SF
N
V
PDNY
S
L
G
D
A
VQAIMDTEKT
L
N
L
P
V
D
ITTQ
F
Q
G
ST
LA
F
Q
SA
L
GS--TVW
L
I
V
-
A
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAE
R
EQ
----------
G
MSPR
EA
IYQ
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
IV
S
Q
V
L
T
L
F
TT
P
VI
Y
L
L
fig|536056.3.peg.1670
Escherichia coli DH1 (17-1021/1040)
I
M
RPVA
TTL
L
----
M
V
A
I
L
L
A
G
IIG
Y
RA
LPV
S
AL
P
E
V
DY
P
T
I
Q
V
V
T
L
YPGA
S
PD
V
M
T
S
A
VT
A
PL
E
RQ
F
GQ
M
S
GL
K
Q
MSS
Q
S
SG-
G
ASV
ITL
Q
F
Q
L
TL
P
L
D
V
A
EQ
E
VQ
AA
IN
A
A
TNL
LP
SDLPNP
P
V
YSKVNPADP
---
P
I
MTL
A
VT
S
T--AMPMT
Q
V
E
D
M
V
ETR
V
AQK
I
S
QIS
GVG
L
V
TLS
G
GQRPAV
R
V
K
L
NA
QA
IA
ALG
L
TSET
V
RT
AI
TGA
N
VNSAK
G
S
L
--
-
-
--DGPSRAVT
L
S
A
NDQ
M
Q
S
A
EE
Y
RQ
L
I
I
AYQ-
N
G
AP
I
R
L
G
DVA
T
VE
Q
G
A
E
NSWLG
A
WA
N
K
E
-
Q
A
I
V
MN
V
Q
R
QP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TES
L
P
K
S
VK
VTVL
S
D
R
T
TN
I
RA
S
V
D
D
TQFE
L
M
M
AI
A
LV
V
M
I
I
YLFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
A
V
M
V
F
L
D
F
S
I
N
N
LT
L
M
A
L
T
I
A
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
K
GEK
P
LA
A
AL
K
GAG
E
I
G
F
TI
ISLTFS
L
I
AV
L
IP
L
L
F
MG
D
IV
G
R
LF
R
E
F
A
IT
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRAS
E
KM
F
DRIIAA
----
Y
GRGLA
KVL
NHPWLT
L
S
V
A
L
S
TLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VA
D
--
VILQDPA
V
Q
S
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQ
V
SR
T
QYQFT
L
QAT---SL
D
A
L
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
QD
KGLVAY
VNVD
RD
S
A
S
R
L
G
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
L
E
HNTEN
T
PG
L
AA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SF
N
V
PDNY
S
L
G
D
A
VQAIMDTEKT
L
N
L
P
V
D
ITTQ
F
Q
G
ST
LA
F
Q
SA
L
GS--TVW
L
I
V
-
A
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAE
R
EQ
----------
G
MSPR
EA
IYQ
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
IV
S
Q
V
L
T
L
F
TT
P
VI
Y
L
L
fig|656393.3.peg.3099
Escherichia coli H299 (17-1021/1040)
I
M
RPVA
TTL
L
----
M
V
A
I
L
L
A
G
IIG
Y
RA
LPV
S
AL
P
E
V
DY
P
T
I
Q
V
V
T
L
YPGA
S
PD
V
M
T
S
A
VT
A
PL
E
RQ
F
GQ
M
S
GL
K
Q
MSS
Q
S
SG-
G
ASV
ITL
Q
F
Q
L
TL
P
L
D
V
A
EQ
E
VQ
AA
IN
A
A
TNL
LP
SDLPNP
P
V
YSKVNPADP
---
P
I
MTL
A
VT
S
T--AMPMT
Q
V
E
D
M
V
ETR
V
AQK
I
S
QIS
GVG
L
V
TLS
G
GQRPAV
R
V
K
L
NA
QA
IA
ALG
L
TSET
V
RT
AI
TGA
N
VNSAK
G
S
L
--
-
-
--DGPSRAVT
L
S
A
NDQ
M
Q
S
A
EE
Y
RQ
L
I
I
AYQ-
N
G
AP
I
R
L
G
DVA
T
VE
Q
G
A
E
NSWLG
A
WA
N
K
E
-
Q
A
I
V
MN
V
Q
R
QP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TES
L
P
K
S
VK
VTVL
S
D
R
T
TN
I
RA
S
V
D
D
TQFE
L
M
M
AI
A
LV
V
M
I
I
YLFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
A
V
M
V
F
L
D
F
S
I
N
N
LT
L
M
A
L
T
I
A
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
K
GEK
P
LA
A
AL
K
GAG
E
I
G
F
TI
ISLTFS
L
I
AV
L
IP
L
L
F
MG
D
IV
G
R
LF
R
E
F
A
IT
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRAS
E
KM
F
DRIIAA
----
Y
GRGLA
KVL
NHPWLT
L
S
V
A
L
S
TLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VA
D
--
VILQDPA
V
Q
S
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQ
V
SR
T
QYQFT
L
QAT---SL
D
A
L
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
QD
KGLVAY
VNVD
RD
S
A
S
R
L
G
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
L
E
HNTEN
T
PG
L
AA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SF
N
V
PDNY
S
L
G
D
A
VQAIMDTEKT
L
N
L
P
V
D
ITTQ
F
Q
G
ST
LA
F
Q
SA
L
GS--TVW
L
I
V
-
A
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAE
R
EQ
----------
G
MSPR
EA
IYQ
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
IV
S
Q
V
L
T
L
F
TT
P
VI
Y
L
L
fig|83333.1.peg.2051
Escherichia coli K12 (17-1021/1040)
I
M
RPVA
TTL
L
----
M
V
A
I
L
L
A
G
IIG
Y
RA
LPV
S
AL
P
E
V
DY
P
T
I
Q
V
V
T
L
YPGA
S
PD
V
M
T
S
A
VT
A
PL
E
RQ
F
GQ
M
S
GL
K
Q
MSS
Q
S
SG-
G
ASV
ITL
Q
F
Q
L
TL
P
L
D
V
A
EQ
E
VQ
AA
IN
A
A
TNL
LP
SDLPNP
P
V
YSKVNPADP
---
P
I
MTL
A
VT
S
T--AMPMT
Q
V
E
D
M
V
ETR
V
AQK
I
S
QIS
GVG
L
V
TLS
G
GQRPAV
R
V
K
L
NA
QA
IA
ALG
L
TSET
V
RT
AI
TGA
N
VNSAK
G
S
L
--
-
-
--DGPSRAVT
L
S
A
NDQ
M
Q
S
A
EE
Y
RQ
L
I
I
AYQ-
N
G
AP
I
R
L
G
DVA
T
VE
Q
G
A
E
NSWLG
A
WA
N
K
E
-
Q
A
I
V
MN
V
Q
R
QP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TES
L
P
K
S
VK
VTVL
S
D
R
T
TN
I
RA
S
V
D
D
TQFE
L
M
M
AI
A
LV
V
M
I
I
YLFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
A
V
M
V
F
L
D
F
S
I
N
N
LT
L
M
A
L
T
I
A
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
K
GEK
P
LA
A
AL
K
GAG
E
I
G
F
TI
ISLTFS
L
I
AV
L
IP
L
L
F
MG
D
IV
G
R
LF
R
E
F
A
IT
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRAS
E
KM
F
DRIIAA
----
Y
GRGLA
KVL
NHPWLT
L
S
V
A
L
S
TLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VA
D
--
VILQDPA
V
Q
S
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQ
V
SR
T
QYQFT
L
QAT---SL
D
A
L
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
QD
KGLVAY
VNVD
RD
S
A
S
R
L
G
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
L
E
HNTEN
T
PG
L
AA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SF
N
V
PDNY
S
L
G
D
A
VQAIMDTEKT
L
N
L
P
V
D
ITTQ
F
Q
G
ST
LA
F
Q
SA
L
GS--TVW
L
I
V
-
A
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAE
R
EQ
----------
G
MSPR
EA
IYQ
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
IV
S
Q
V
L
T
L
F
TT
P
VI
Y
L
L
fig|595495.4.peg.2945
Escherichia coli KO11 (17-1021/1040)
I
M
RPVA
TTL
L
----
M
V
A
I
L
L
A
G
IIG
Y
RA
LPV
S
AL
P
E
V
DY
P
T
I
Q
V
V
T
L
YPGA
S
PD
V
M
T
S
A
VT
A
PL
E
RQ
F
GQ
M
S
GL
K
Q
MSS
Q
S
SG-
G
ASV
ITL
Q
F
Q
L
TL
P
L
D
V
A
EQ
E
VQ
AA
IN
A
A
TNL
LP
SDLPNP
P
V
YSKVNPADP
---
P
I
MTL
A
VT
S
T--AMPMT
Q
V
E
D
M
V
ETR
V
AQK
I
S
QIS
GVG
L
V
TLS
G
GQRPAV
R
V
K
L
NA
QA
IA
ALG
L
TSET
V
RT
AI
TGA
N
VNSAK
G
S
L
--
-
-
--DGPSRAVT
L
S
A
NDQ
M
Q
S
A
EE
Y
RQ
L
I
I
AYQ-
N
G
AP
I
R
L
G
DVA
T
VE
Q
G
A
E
NSWLG
A
WA
N
K
E
-
Q
A
I
V
MN
V
Q
R
QP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TES
L
P
K
S
VK
VTVL
S
D
R
T
TN
I
RA
S
V
D
D
TQFE
L
M
M
AI
A
LV
V
M
I
I
YLFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
A
V
M
V
F
L
D
F
S
I
N
N
LT
L
M
A
L
T
I
A
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
K
GEK
P
LA
A
AL
K
GAG
E
I
G
F
TI
ISLTFS
L
I
AV
L
IP
L
L
F
MG
D
IV
G
R
LF
R
E
F
A
IT
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRAS
E
KM
F
DRIIAA
----
Y
GRGLA
KVL
NHPWLT
L
S
V
A
L
S
TLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VA
D
--
VILQDPA
V
Q
S
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQ
V
SR
T
QYQFT
L
QAT---SL
D
A
L
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
QD
KGLVAY
VNVD
RD
S
A
S
R
L
G
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
L
E
HNTEN
T
PG
L
AA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SF
N
V
PDNY
S
L
G
D
A
VQAIMDTEKT
L
N
L
P
V
D
ITTQ
F
Q
G
ST
LA
F
Q
SA
L
GS--TVW
L
I
V
-
A
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAE
R
EQ
----------
G
MSPR
EA
IYQ
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
IV
S
Q
V
L
T
L
F
TT
P
VI
Y
L
L
fig|656419.3.peg.2830
Escherichia coli M718 (17-1021/1040)
I
M
RPVA
TTL
L
----
M
V
A
I
L
L
A
G
IIG
Y
RA
LPV
S
AL
P
E
V
DY
P
T
I
Q
V
V
T
L
YPGA
S
PD
V
M
T
S
A
VT
A
PL
E
RQ
F
GQ
M
S
GL
K
Q
MSS
Q
S
SG-
G
ASV
ITL
Q
F
Q
L
TL
P
L
D
V
A
EQ
E
VQ
AA
IN
A
A
TNL
LP
SDLPNP
P
V
YSKVNPADP
---
P
I
MTL
A
VT
S
T--AMPMT
Q
V
E
D
M
V
ETR
V
AQK
I
S
QIS
GVG
L
V
TLS
G
GQRPAV
R
V
K
L
NA
QA
IA
ALG
L
TSET
V
RT
AI
TGA
N
VNSAK
G
S
L
--
-
-
--DGPSRAVT
L
S
A
NDQ
M
Q
S
A
EE
Y
RQ
L
I
I
AYQ-
N
G
AP
I
R
L
G
DVA
T
VE
Q
G
A
E
NSWLG
A
WA
N
K
E
-
Q
A
I
V
MN
V
Q
R
QP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TES
L
P
K
S
VK
VTVL
S
D
R
T
TN
I
RA
S
V
D
D
TQFE
L
M
M
AI
A
LV
V
M
I
I
YLFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
A
V
M
V
F
L
D
F
S
I
N
N
LT
L
M
A
L
T
I
A
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
K
GEK
P
LA
A
AL
K
GAG
E
I
G
F
TI
ISLTFS
L
I
AV
L
IP
L
L
F
MG
D
IV
G
R
LF
R
E
F
A
IT
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRAS
E
KM
F
DRIIAA
----
Y
GRGLA
KVL
NHPWLT
L
S
V
A
L
S
TLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VA
D
--
VILQDPA
V
Q
S
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQ
V
SR
T
QYQFT
L
QAT---SL
D
A
L
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
QD
KGLVAY
VNVD
RD
S
A
S
R
L
G
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
L
E
HNTEN
T
PG
L
AA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SF
N
V
PDNY
S
L
G
D
A
VQAIMDTEKT
L
N
L
P
V
D
ITTQ
F
Q
G
ST
LA
F
Q
SA
L
GS--TVW
L
I
V
-
A
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAE
R
EQ
----------
G
MSPR
EA
IYQ
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
IV
S
Q
V
L
T
L
F
TT
P
VI
Y
L
L
fig|749540.3.peg.199
Escherichia coli MS 146-1 (17-1021/1040)
I
M
RPVA
TTL
L
----
M
V
A
I
L
L
A
G
IIG
Y
RA
LPV
S
AL
P
E
V
DY
P
T
I
Q
V
V
T
L
YPGA
S
PD
V
M
T
S
A
VT
A
PL
E
RQ
F
GQ
M
S
GL
K
Q
MSS
Q
S
SG-
G
ASV
ITL
Q
F
Q
L
TL
P
L
D
V
A
EQ
E
VQ
AA
IN
A
A
TNL
LP
SDLPNP
P
V
YSKVNPADP
---
P
I
MTL
A
VT
S
T--AMPMT
Q
V
E
D
M
V
ETR
V
AQK
I
S
QIS
GVG
L
V
TLS
G
GQRPAV
R
V
K
L
NA
QA
IA
ALG
L
TSET
V
RT
AI
TGA
N
VNSAK
G
S
L
--
-
-
--DGPSRAVT
L
S
A
NDQ
M
Q
S
A
EE
Y
RQ
L
I
I
AYQ-
N
G
AP
I
R
L
G
DVA
T
VE
Q
G
A
E
NSWLG
A
WA
N
K
E
-
Q
A
I
V
MN
V
Q
R
QP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TES
L
P
K
S
VK
VTVL
S
D
R
T
TN
I
RA
S
V
D
D
TQFE
L
M
M
AI
A
LV
V
M
I
I
YLFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
A
V
M
V
F
L
D
F
S
I
N
N
LT
L
M
A
L
T
I
A
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
K
GEK
P
LA
A
AL
K
GAG
E
I
G
F
TI
ISLTFS
L
I
AV
L
IP
L
L
F
MG
D
IV
G
R
LF
R
E
F
A
IT
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRAS
E
KM
F
DRIIAA
----
Y
GRGLA
KVL
NHPWLT
L
S
V
A
L
S
TLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VA
D
--
VILQDPA
V
Q
S
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQ
V
SR
T
QYQFT
L
QAT---SL
D
A
L
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
QD
KGLVAY
VNVD
RD
S
A
S
R
L
G
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
L
E
HNTEN
T
PG
L
AA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SF
N
V
PDNY
S
L
G
D
A
VQAIMDTEKT
L
N
L
P
V
D
ITTQ
F
Q
G
ST
LA
F
Q
SA
L
GS--TVW
L
I
V
-
A
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LTAE
R
EQ
----------
G
MSPR
EA
IYQ
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
IV
S
Q
V
L
T
L
F
TT
P
VI
Y
L
L
fig|566546.3.peg.2499
Escherichia coli W (17-1021/1040)
I
M
RPVA
TTL
L
----
M
V
A
I
L
L
A
G
IIG
Y
RA
LPV
S
AL
P
E
V
DY
P
T
I
Q
V
V
T
L
YPGA
S
PD
V
M
T
S
A
VT
A
PL
E
RQ
F
GQ
M
S
GL
K
Q
MSS
Q
S
SG-
G
ASV
ITL
Q
F
Q
L
TL
P
L
D
V
A
EQ
E
VQ
AA
IN
A
A
TNL
LP
SDLPNP
P
V
YSKVNPADP
---
P
I
MTL
A
VT
S
T--AMPMT
Q
V
E
D
M
V
ETR
V
AQK
I
S
QIS
GVG
L
V
TLS
G
GQRPAV
R
V
K
L
NA
QA
IA
ALG
L
TSET
V
RT
AI
TGA
N
VNSAK
G
S
L
--
-
-
--DGPSRAVT
L
S
A
NDQ
M
Q
S
A
EE
Y
RQ
L
I
I
AYQ-
N
G
AP
I
R
L
G
DVA
T
VE
Q
G
A
E
NSWLG
A
WA
N
K
E
-
Q
A
I
V
MN
V
Q
R
QP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TES
L
P
K
S
VK
VTVL
S
D
R
T
TN
I
RA
S
V
D
D
TQFE
L
M
M
AI
A
LV
V
M
I
I
YLFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
A
V
M
V
F
L
D
F
S
I
N
N
LT
L
M
A
L
T
I
A
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
K
GEK
P
LA
A
AL
K
GAG
E
I
G
F
TI
ISLTFS
L
I
AV
L
IP
L
L
F
MG
D
IV
G
R
LF
R
E
F
A
IT
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRAS
E
KM
F
DRIIAA
----
Y
GRGLA
KVL
NHPWLT
L
S
V
A
L
S
TLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VA
D
--
VILQDPA
V
Q
S
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQ
V
SR
T
QYQFT
L
QAT---SL
D
A
L
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
QD
KGLVAY
VNVD
RD
S
A
S
R
L
G
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
L
E
HNTEN
T
PG
L
AA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SF
N
V
PDNY
S
L
G
D
A
VQAIMDTEKT
L
N
L
P
V
D
ITTQ
F
Q
G
ST
LA
F
Q
SA
L
GS--TVW
L
I
V
-
A
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAE
R
EQ
----------
G
MSPR
EA
IYQ
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
IV
S
Q
V
L
T
L
F
TT
P
VI
Y
L
L
fig|566546.4.peg.2219
Escherichia coli W (17-1021/1040)
I
M
RPVA
TTL
L
----
M
V
A
I
L
L
A
G
IIG
Y
RA
LPV
S
AL
P
E
V
DY
P
T
I
Q
V
V
T
L
YPGA
S
PD
V
M
T
S
A
VT
A
PL
E
RQ
F
GQ
M
S
GL
K
Q
MSS
Q
S
SG-
G
ASV
ITL
Q
F
Q
L
TL
P
L
D
V
A
EQ
E
VQ
AA
IN
A
A
TNL
LP
SDLPNP
P
V
YSKVNPADP
---
P
I
MTL
A
VT
S
T--AMPMT
Q
V
E
D
M
V
ETR
V
AQK
I
S
QIS
GVG
L
V
TLS
G
GQRPAV
R
V
K
L
NA
QA
IA
ALG
L
TSET
V
RT
AI
TGA
N
VNSAK
G
S
L
--
-
-
--DGPSRAVT
L
S
A
NDQ
M
Q
S
A
EE
Y
RQ
L
I
I
AYQ-
N
G
AP
I
R
L
G
DVA
T
VE
Q
G
A
E
NSWLG
A
WA
N
K
E
-
Q
A
I
V
MN
V
Q
R
QP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TES
L
P
K
S
VK
VTVL
S
D
R
T
TN
I
RA
S
V
D
D
TQFE
L
M
M
AI
A
LV
V
M
I
I
YLFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
A
V
M
V
F
L
D
F
S
I
N
N
LT
L
M
A
L
T
I
A
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
K
GEK
P
LA
A
AL
K
GAG
E
I
G
F
TI
ISLTFS
L
I
AV
L
IP
L
L
F
MG
D
IV
G
R
LF
R
E
F
A
IT
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRAS
E
KM
F
DRIIAA
----
Y
GRGLA
KVL
NHPWLT
L
S
V
A
L
S
TLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VA
D
--
VILQDPA
V
Q
S
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQ
V
SR
T
QYQFT
L
QAT---SL
D
A
L
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
QD
KGLVAY
VNVD
RD
S
A
S
R
L
G
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
L
E
HNTEN
T
PG
L
AA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SF
N
V
PDNY
S
L
G
D
A
VQAIMDTEKT
L
N
L
P
V
D
ITTQ
F
Q
G
ST
LA
F
Q
SA
L
GS--TVW
L
I
V
-
A
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAE
R
EQ
----------
G
MSPR
EA
IYQ
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
IV
S
Q
V
L
T
L
F
TT
P
VI
Y
L
L
fig|316407.3.peg.2011
Escherichia coli W3110 (17-1021/1040)
I
M
RPVA
TTL
L
----
M
V
A
I
L
L
A
G
IIG
Y
RA
LPV
S
AL
P
E
V
DY
P
T
I
Q
V
V
T
L
YPGA
S
PD
V
M
T
S
A
VT
A
PL
E
RQ
F
GQ
M
S
GL
K
Q
MSS
Q
S
SG-
G
ASV
ITL
Q
F
Q
L
TL
P
L
D
V
A
EQ
E
VQ
AA
IN
A
A
TNL
LP
SDLPNP
P
V
YSKVNPADP
---
P
I
MTL
A
VT
S
T--AMPMT
Q
V
E
D
M
V
ETR
V
AQK
I
S
QIS
GVG
L
V
TLS
G
GQRPAV
R
V
K
L
NA
QA
IA
ALG
L
TSET
V
RT
AI
TGA
N
VNSAK
G
S
L
--
-
-
--DGPSRAVT
L
S
A
NDQ
M
Q
S
A
EE
Y
RQ
L
I
I
AYQ-
N
G
AP
I
R
L
G
DVA
T
VE
Q
G
A
E
NSWLG
A
WA
N
K
E
-
Q
A
I
V
MN
V
Q
R
QP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TES
L
P
K
S
VK
VTVL
S
D
R
T
TN
I
RA
S
V
D
D
TQFE
L
M
M
AI
A
LV
V
M
I
I
YLFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
A
V
M
V
F
L
D
F
S
I
N
N
LT
L
M
A
L
T
I
A
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
K
GEK
P
LA
A
AL
K
GAG
E
I
G
F
TI
ISLTFS
L
I
AV
L
IP
L
L
F
MG
D
IV
G
R
LF
R
E
F
A
IT
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRAS
E
KM
F
DRIIAA
----
Y
GRGLA
KVL
NHPWLT
L
S
V
A
L
S
TLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VA
D
--
VILQDPA
V
Q
S
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQ
V
SR
T
QYQFT
L
QAT---SL
D
A
L
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
QD
KGLVAY
VNVD
RD
S
A
S
R
L
G
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
L
E
HNTEN
T
PG
L
AA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SF
N
V
PDNY
S
L
G
D
A
VQAIMDTEKT
L
N
L
P
V
D
ITTQ
F
Q
G
ST
LA
F
Q
SA
L
GS--TVW
L
I
V
-
A
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAE
R
EQ
----------
G
MSPR
EA
IYQ
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
IV
S
Q
V
L
T
L
F
TT
P
VI
Y
L
L
fig|316385.7.peg.2240
Escherichia coli str. K-12 substr. DH10B (17-1021/1040)
I
M
RPVA
TTL
L
----
M
V
A
I
L
L
A
G
IIG
Y
RA
LPV
S
AL
P
E
V
DY
P
T
I
Q
V
V
T
L
YPGA
S
PD
V
M
T
S
A
VT
A
PL
E
RQ
F
GQ
M
S
GL
K
Q
MSS
Q
S
SG-
G
ASV
ITL
Q
F
Q
L
TL
P
L
D
V
A
EQ
E
VQ
AA
IN
A
A
TNL
LP
SDLPNP
P
V
YSKVNPADP
---
P
I
MTL
A
VT
S
T--AMPMT
Q
V
E
D
M
V
ETR
V
AQK
I
S
QIS
GVG
L
V
TLS
G
GQRPAV
R
V
K
L
NA
QA
IA
ALG
L
TSET
V
RT
AI
TGA
N
VNSAK
G
S
L
--
-
-
--DGPSRAVT
L
S
A
NDQ
M
Q
S
A
EE
Y
RQ
L
I
I
AYQ-
N
G
AP
I
R
L
G
DVA
T
VE
Q
G
A
E
NSWLG
A
WA
N
K
E
-
Q
A
I
V
MN
V
Q
R
QP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TES
L
P
K
S
VK
VTVL
S
D
R
T
TN
I
RA
S
V
D
D
TQFE
L
M
M
AI
A
LV
V
M
I
I
YLFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
A
V
M
V
F
L
D
F
S
I
N
N
LT
L
M
A
L
T
I
A
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
K
GEK
P
LA
A
AL
K
GAG
E
I
G
F
TI
ISLTFS
L
I
AV
L
IP
L
L
F
MG
D
IV
G
R
LF
R
E
F
A
IT
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRAS
E
KM
F
DRIIAA
----
Y
GRGLA
KVL
NHPWLT
L
S
V
A
L
S
TLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VA
D
--
VILQDPA
V
Q
S
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQ
V
SR
T
QYQFT
L
QAT---SL
D
A
L
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
QD
KGLVAY
VNVD
RD
S
A
S
R
L
G
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
L
E
HNTEN
T
PG
L
AA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SF
N
V
PDNY
S
L
G
D
A
VQAIMDTEKT
L
N
L
P
V
D
ITTQ
F
Q
G
ST
LA
F
Q
SA
L
GS--TVW
L
I
V
-
A
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAE
R
EQ
----------
G
MSPR
EA
IYQ
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
IV
S
Q
V
L
T
L
F
TT
P
VI
Y
L
L
fig|511145.12.peg.2152
Escherichia coli str. K-12 substr. MG1655 (17-1021/1040)
I
M
RPVA
TTL
L
----
M
V
A
I
L
L
A
G
IIG
Y
RA
LPV
S
AL
P
E
V
DY
P
T
I
Q
V
V
T
L
YPGA
S
PD
V
M
T
S
A
VT
A
PL
E
RQ
F
GQ
M
S
GL
K
Q
MSS
Q
S
SG-
G
ASV
ITL
Q
F
Q
L
TL
P
L
D
V
A
EQ
E
VQ
AA
IN
A
A
TNL
LP
SDLPNP
P
V
YSKVNPADP
---
P
I
MTL
A
VT
S
T--AMPMT
Q
V
E
D
M
V
ETR
V
AQK
I
S
QIS
GVG
L
V
TLS
G
GQRPAV
R
V
K
L
NA
QA
IA
ALG
L
TSET
V
RT
AI
TGA
N
VNSAK
G
S
L
--
-
-
--DGPSRAVT
L
S
A
NDQ
M
Q
S
A
EE
Y
RQ
L
I
I
AYQ-
N
G
AP
I
R
L
G
DVA
T
VE
Q
G
A
E
NSWLG
A
WA
N
K
E
-
Q
A
I
V
MN
V
Q
R
QP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TES
L
P
K
S
VK
VTVL
S
D
R
T
TN
I
RA
S
V
D
D
TQFE
L
M
M
AI
A
LV
V
M
I
I
YLFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
A
V
M
V
F
L
D
F
S
I
N
N
LT
L
M
A
L
T
I
A
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
K
GEK
P
LA
A
AL
K
GAG
E
I
G
F
TI
ISLTFS
L
I
AV
L
IP
L
L
F
MG
D
IV
G
R
LF
R
E
F
A
IT
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRAS
E
KM
F
DRIIAA
----
Y
GRGLA
KVL
NHPWLT
L
S
V
A
L
S
TLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VA
D
--
VILQDPA
V
Q
S
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQ
V
SR
T
QYQFT
L
QAT---SL
D
A
L
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
QD
KGLVAY
VNVD
RD
S
A
S
R
L
G
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
L
E
HNTEN
T
PG
L
AA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SF
N
V
PDNY
S
L
G
D
A
VQAIMDTEKT
L
N
L
P
V
D
ITTQ
F
Q
G
ST
LA
F
Q
SA
L
GS--TVW
L
I
V
-
A
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAE
R
EQ
----------
G
MSPR
EA
IYQ
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
IV
S
Q
V
L
T
L
F
TT
P
VI
Y
L
L
fig|511145.6.peg.2137
Escherichia coli str. K-12 substr. MG1655 (17-1021/1040)
I
M
RPVA
TTL
L
----
M
V
A
I
L
L
A
G
IIG
Y
RA
LPV
S
AL
P
E
V
DY
P
T
I
Q
V
V
T
L
YPGA
S
PD
V
M
T
S
A
VT
A
PL
E
RQ
F
GQ
M
S
GL
K
Q
MSS
Q
S
SG-
G
ASV
ITL
Q
F
Q
L
TL
P
L
D
V
A
EQ
E
VQ
AA
IN
A
A
TNL
LP
SDLPNP
P
V
YSKVNPADP
---
P
I
MTL
A
VT
S
T--AMPMT
Q
V
E
D
M
V
ETR
V
AQK
I
S
QIS
GVG
L
V
TLS
G
GQRPAV
R
V
K
L
NA
QA
IA
ALG
L
TSET
V
RT
AI
TGA
N
VNSAK
G
S
L
--
-
-
--DGPSRAVT
L
S
A
NDQ
M
Q
S
A
EE
Y
RQ
L
I
I
AYQ-
N
G
AP
I
R
L
G
DVA
T
VE
Q
G
A
E
NSWLG
A
WA
N
K
E
-
Q
A
I
V
MN
V
Q
R
QP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TES
L
P
K
S
VK
VTVL
S
D
R
T
TN
I
RA
S
V
D
D
TQFE
L
M
M
AI
A
LV
V
M
I
I
YLFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
A
V
M
V
F
L
D
F
S
I
N
N
LT
L
M
A
L
T
I
A
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
K
GEK
P
LA
A
AL
K
GAG
E
I
G
F
TI
ISLTFS
L
I
AV
L
IP
L
L
F
MG
D
IV
G
R
LF
R
E
F
A
IT
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRAS
E
KM
F
DRIIAA
----
Y
GRGLA
KVL
NHPWLT
L
S
V
A
L
S
TLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VA
D
--
VILQDPA
V
Q
S
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQ
V
SR
T
QYQFT
L
QAT---SL
D
A
L
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
QD
KGLVAY
VNVD
RD
S
A
S
R
L
G
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
L
E
HNTEN
T
PG
L
AA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SF
N
V
PDNY
S
L
G
D
A
VQAIMDTEKT
L
N
L
P
V
D
ITTQ
F
Q
G
ST
LA
F
Q
SA
L
GS--TVW
L
I
V
-
A
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAE
R
EQ
----------
G
MSPR
EA
IYQ
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
IV
S
Q
V
L
T
L
F
TT
P
VI
Y
L
L
fig|340185.3.peg.1199
Escherichia coli E22 (17-1021/1040)
I
M
RPVA
TTL
L
----
M
V
A
I
L
L
A
G
IIG
Y
RA
LPV
S
AL
P
E
V
DY
P
T
I
Q
V
V
T
L
YPGA
S
PD
V
M
T
S
A
VT
A
PL
E
RQ
F
GQ
M
S
GL
K
Q
MSS
Q
S
SG-
G
ASV
ITL
Q
F
Q
L
TL
P
L
D
V
A
EQ
E
VQ
AA
IN
A
A
TNL
LP
SDLPNP
P
V
YSKVNPADP
---
P
I
MTL
A
VT
S
T--AMPMT
Q
V
E
D
M
V
ETR
V
AQK
I
S
QIS
GVG
L
V
TLS
G
GQRPAV
R
V
K
L
NA
QA
IA
ALG
L
TSET
V
RT
AI
TGA
N
VNSAK
G
S
L
--
-
-
--DGPSRAVT
L
S
A
NDQ
M
Q
S
A
EE
Y
RQ
L
I
I
AYQ-
N
G
AP
I
R
L
G
DVA
T
VE
Q
G
A
E
NSWLG
A
WA
N
K
E
-
Q
A
I
V
MN
V
Q
R
QP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TES
L
P
K
S
VK
VTVL
S
D
R
T
TN
I
RA
S
V
D
D
TQFE
L
M
M
AI
A
LV
V
M
I
I
YLFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
A
V
M
V
F
L
D
F
S
I
N
N
LT
L
M
A
L
T
I
A
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
K
GEK
P
LA
A
AL
K
GAG
E
I
G
F
TI
ISLTFS
L
I
AV
L
IP
L
L
F
MG
D
IV
G
R
LF
R
E
F
A
IT
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRAS
E
KM
F
DRIIAA
----
Y
GRGLA
KVL
NHPWLT
L
S
V
A
L
S
TLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VA
D
--
VILQDPA
V
Q
S
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQ
V
SR
T
QYQFT
L
QAT---SL
D
A
L
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
QD
KGLVAY
VNVD
RD
S
A
S
R
L
G
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
L
E
HNTEI
T
PG
L
AA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KVEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SF
N
V
PDNY
S
L
G
D
A
VQAIMDTEKT
L
N
L
P
V
D
ITTQ
F
Q
G
ST
LA
F
Q
SA
L
GS--TVW
L
I
V
-
A
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAE
R
EQ
----------
G
MSPR
EA
IYQ
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
IV
S
Q
V
L
T
L
F
TT
P
VI
Y
L
L
fig|340185.4.peg.1265
Escherichia coli E22 (17-1021/1040)
I
M
RPVA
TTL
L
----
M
V
A
I
L
L
A
G
IIG
Y
RA
LPV
S
AL
P
E
V
DY
P
T
I
Q
V
V
T
L
YPGA
S
PD
V
M
T
S
A
VT
A
PL
E
RQ
F
GQ
M
S
GL
K
Q
MSS
Q
S
SG-
G
ASV
ITL
Q
F
Q
L
TL
P
L
D
V
A
EQ
E
VQ
AA
IN
A
A
TNL
LP
SDLPNP
P
V
YSKVNPADP
---
P
I
MTL
A
VT
S
T--AMPMT
Q
V
E
D
M
V
ETR
V
AQK
I
S
QIS
GVG
L
V
TLS
G
GQRPAV
R
V
K
L
NA
QA
IA
ALG
L
TSET
V
RT
AI
TGA
N
VNSAK
G
S
L
--
-
-
--DGPSRAVT
L
S
A
NDQ
M
Q
S
A
EE
Y
RQ
L
I
I
AYQ-
N
G
AP
I
R
L
G
DVA
T
VE
Q
G
A
E
NSWLG
A
WA
N
K
E
-
Q
A
I
V
MN
V
Q
R
QP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TES
L
P
K
S
VK
VTVL
S
D
R
T
TN
I
RA
S
V
D
D
TQFE
L
M
M
AI
A
LV
V
M
I
I
YLFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
A
V
M
V
F
L
D
F
S
I
N
N
LT
L
M
A
L
T
I
A
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
K
GEK
P
LA
A
AL
K
GAG
E
I
G
F
TI
ISLTFS
L
I
AV
L
IP
L
L
F
MG
D
IV
G
R
LF
R
E
F
A
IT
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRAS
E
KM
F
DRIIAA
----
Y
GRGLA
KVL
NHPWLT
L
S
V
A
L
S
TLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VA
D
--
VILQDPA
V
Q
S
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQ
V
SR
T
QYQFT
L
QAT---SL
D
A
L
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
QD
KGLVAY
VNVD
RD
S
A
S
R
L
G
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
L
E
HNTEI
T
PG
L
AA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KVEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SF
N
V
PDNY
S
L
G
D
A
VQAIMDTEKT
L
N
L
P
V
D
ITTQ
F
Q
G
ST
LA
F
Q
SA
L
GS--TVW
L
I
V
-
A
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAE
R
EQ
----------
G
MSPR
EA
IYQ
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
IV
S
Q
V
L
T
L
F
TT
P
VI
Y
L
L
fig|585395.4.peg.2670
Escherichia coli O103:H2 str. 12009 (17-1021/1040)
I
M
RPVA
TTL
L
----
M
V
A
I
L
L
A
G
IIG
Y
RA
LPV
S
AL
P
E
V
DY
P
T
I
Q
V
V
T
L
YPGA
S
PD
V
M
T
S
A
VT
A
PL
E
RQ
F
GQ
M
S
GL
K
Q
MSS
Q
S
SG-
G
ASV
ITL
Q
F
Q
L
TL
P
L
D
V
A
EQ
E
VQ
AA
IN
A
A
TNL
LP
SDLPNP
P
V
YSKVNPADP
---
P
I
MTL
A
VT
S
T--AMPMT
Q
V
E
D
M
V
ETR
V
AQK
I
S
QIS
GVG
L
V
TLS
G
GQRPAV
R
V
K
L
NA
QA
IA
ALG
L
TSET
V
RT
AI
TGA
N
VNSAK
G
S
L
--
-
-
--DGPSRAVT
L
S
A
NDQ
M
Q
S
A
EE
Y
RQ
L
I
I
AYQ-
N
G
AP
I
R
L
G
DVA
T
VE
Q
G
A
E
NSWLG
A
WA
N
K
E
-
Q
A
I
V
MN
V
Q
R
QP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TES
L
P
K
S
VK
VTVL
S
D
R
T
TN
I
RA
S
V
D
D
TQFE
L
M
M
AI
A
LV
V
M
I
I
YLFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
A
V
M
V
F
L
D
F
S
I
N
N
LT
L
M
A
L
T
I
A
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
K
GEK
P
LA
A
AL
K
GAG
E
I
G
F
TI
ISLTFS
L
I
AV
L
IP
L
L
F
MG
D
IV
G
R
LF
R
E
F
A
IT
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRAS
E
KM
F
DRIIAA
----
Y
GRGLA
KVL
NHPWLT
L
S
V
A
L
S
TLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VA
D
--
VILQDPA
V
Q
S
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQ
V
SR
T
QYQFT
L
QAT---SL
D
A
L
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
QD
KGLVAY
VNVD
RD
S
A
S
R
L
G
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
L
E
HNTEI
T
PG
L
AA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KVEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SF
N
V
PDNY
S
L
G
D
A
VQAIMDTEKT
L
N
L
P
V
D
ITTQ
F
Q
G
ST
LA
F
Q
SA
L
GS--TVW
L
I
V
-
A
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAE
R
EQ
----------
G
MSPR
EA
IYQ
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
IV
S
Q
V
L
T
L
F
TT
P
VI
Y
L
L
fig|670897.3.peg.3434
Escherichia coli 2362-75 (16-1026/1037)
AI
L
L
C
L
T
G
TLA
I
FS
LPV
E
QYP
D
L
AP
P
N
V
R
V
T
A
N
YPGA
S
AQ
T
L
E
N
T
V
P
Q
VIE
QN
M
TG
L
D
N
LM
Y
MSS
Q
S
SGT
G
QAS
V
TL
S
F
K
A
GT
D
PD
E
A
VQ
QVQ
NQ
LQ
S
A
MRK
LP
QAVQNQ
GV
TVR-KTGDT
---
N
I
LTI
A
FV
S
TDGSMDKQ
DI
A
D
Y
V
ASN
I
QDP
LS
RVN
GVG
D
I
DAY
G
SQY-SM
RI
W
LDP
AK
LN
SFQ
M
TAKD
V
TD
AI
ESQ
N
AQIAV
GQLGG
T
P
SVDKQALNAT
I
N
A
QSL
LQT
P
E
Q
F
RD
I
T
L
RVNQ
DG
SE
V
R
L
G
DVA
T
VE
M
G
A
E
KYDYL
S
RF
NGK
-
P
A
S
G
LG
V
K
L
AS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQY
FP
H
G
L
E
YKVA
Y
E
TT
SF
V
KA
SI
E
D
VVKT
L
L
EAI
A
LV
F
LV
M
YLFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
S
VL
Y
A
F
G
Y
S
V
N
T
LTM
F
A
M
V
LA
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
E
GLT
P
RE
A
TR
K
SMG
QIQ
G
AL
VGIAMV
L
S
AVF
V
PM
A
F
FG
G
TT
G
A
IYR
Q
FSIT
IVA
AM
VL
SV
L
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWF
N
QM
F
NRNAER
----
Y
EKGVA
K
I
L
HRSLRW
I
V
I
Y
V
L
LLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IE
K
YY
FTHEKDN
I
M
SVF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFNKIKEAR
V
I--
A
S
-
SPPA
I
SGL
G
SS
A
GFDME
L
QDHAGAGH
D
A
L
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
L
D
DSPQLQ
ID
I
D
QR
KA
Q
A
L
GV
AI
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
ML
P
DD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VG
EA
APGV
S
T
G
T
A
MDIMESLVKQ
L
-
-
P
N
G
FGLE
W
T
A
--
MS
YQ
ER
L
SGAQAPA
L
Y
A
-
I
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NEMN
Q
K-
----------
G
HDLF
EA
TLH
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
S
T
GAGSG
GQHA
VG
T
GVMGGM
IS
A
T
I
LAI
Y
FV
P
LF
F
V
LV
fig|656408.3.peg.2278
Escherichia coli H591 (17-1021/1040)
I
M
RPVA
TTL
L
----
M
V
A
I
L
L
A
G
IIG
Y
RA
LPV
S
AL
P
E
V
DY
P
T
I
Q
V
V
T
L
YPGA
S
PD
V
M
T
S
A
VT
A
PL
E
RQ
F
GQ
M
S
GL
K
Q
MSS
Q
S
SG-
G
ASV
ITL
Q
F
Q
L
TL
P
L
D
V
A
EQ
E
VQ
AA
IN
A
A
TNL
LP
SDLPNP
P
V
YSKVNPADP
---
P
I
MTL
A
VT
S
T--AMPMT
Q
V
E
D
M
V
ETR
V
AQK
I
S
QIS
GVG
L
V
TLS
G
GQRPAV
R
V
K
L
NA
QA
IA
ALG
L
TSET
V
RT
AI
TGA
N
VNSAK
G
S
L
--
-
-
--DGPSRAVT
L
S
A
NDQ
M
Q
S
A
EE
Y
RQ
L
I
I
AYQ-
N
G
AP
I
R
L
G
DVA
T
VE
Q
G
A
E
NSWLG
A
WA
N
K
E
-
Q
A
I
V
MN
V
Q
R
QP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TES
L
P
K
S
VK
VTVL
S
D
R
T
TN
I
RA
S
V
D
D
TQFE
L
M
M
AI
A
LV
V
M
I
I
YLFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
A
V
M
V
F
L
D
F
S
I
N
N
LT
L
M
A
L
T
I
A
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
K
GEK
P
LA
A
AL
K
GAG
E
I
G
F
TI
ISLTFS
L
I
AV
L
IP
L
L
F
MG
D
IV
G
R
LF
R
E
F
A
IT
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRAS
E
KM
F
DRIIAA
----
Y
GQGLA
KVL
NHPWLT
L
S
V
A
L
S
TLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VA
D
--
VILQDPA
V
Q
S
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LE
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQ
V
SR
T
QYQFT
L
QAT---SL
D
A
L
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
QD
KGLVAY
VNVD
RD
S
A
S
R
L
G
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
L
E
HNTEN
T
PG
L
AA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KVEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SF
N
V
PDNY
S
L
G
D
A
VQAIMDTEKT
L
N
L
P
V
D
ITTQ
F
Q
G
ST
LA
F
Q
SA
L
GS--TVW
L
I
V
-
A
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAE
R
EQ
----------
G
MSPR
D
A
IYQ
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
IV
S
Q
V
L
T
L
F
TT
P
VI
Y
L
L
fig|749545.3.peg.10
Escherichia coli MS 182-1 (17-1021/1040)
I
M
RPVA
TTL
L
----
M
V
A
I
L
L
A
G
IIG
Y
RA
LPV
S
AL
P
E
V
DY
P
T
I
Q
V
V
T
L
YPGA
S
PD
V
M
T
S
A
VT
A
PL
E
RQ
F
GQ
M
S
GL
K
Q
MSS
Q
S
SG-
G
ASV
ITL
Q
F
Q
L
TL
P
L
D
V
A
EQ
E
VQ
AA
IN
A
A
TNL
LP
SDLPNP
P
V
YSKVNPADP
---
P
I
MTL
A
VT
S
T--AMPMT
Q
V
E
D
M
V
ETR
V
AQK
I
S
QIS
GVG
L
V
TLS
G
GQRPAV
R
V
K
L
NA
QA
IA
ALG
L
TSET
V
RT
AI
TGA
N
VNSAK
G
S
L
--
-
-
--DGPSRAVT
L
S
A
NDQ
M
Q
S
A
EE
Y
RQ
L
I
I
AYQ-
N
G
AP
I
R
L
G
DVA
T
VE
Q
G
A
E
NSWLG
A
WA
N
K
E
-
Q
A
I
V
MN
V
Q
R
QP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TES
L
P
K
S
VK
VTVL
S
D
R
T
TN
I
RA
S
V
D
D
TQFE
L
M
M
AI
A
LV
V
M
I
I
YLFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
A
V
M
V
F
L
D
F
S
I
N
N
LT
L
M
A
L
T
I
A
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
K
GEK
P
LA
A
AL
K
GAG
E
I
G
F
TI
ISLTFS
L
I
AV
L
IP
L
L
F
MG
D
IV
G
R
LF
R
E
F
A
IT
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRAS
E
KM
F
DRIIAA
----
Y
GQGLA
KVL
NHPWLT
L
S
V
A
L
S
TLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VA
D
--
VILQDPA
V
Q
S
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LE
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQ
V
SR
T
QYQFT
L
QAT---SL
D
A
L
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
QD
KGLVAY
VNVD
RD
S
A
S
R
L
G
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
L
E
HNTEN
T
PG
L
AA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KVEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SF
N
V
PDNY
S
L
G
D
A
VQAIMDTEKT
L
N
L
P
V
D
ITTQ
F
Q
G
ST
LA
F
Q
SA
L
GS--TVW
L
I
V
-
A
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAE
R
EQ
----------
G
MSPR
D
A
IYQ
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
IV
S
Q
V
L
T
L
F
TT
P
VI
Y
L
L
fig|679205.4.peg.2972
Escherichia coli MS 124-1 (17-1021/1040)
I
M
RPVA
TTL
L
----
M
V
A
I
L
L
A
G
IIG
Y
RA
LPV
S
AL
P
E
V
DY
P
T
I
Q
V
V
T
L
YPGA
S
PD
V
M
T
S
A
VT
A
PL
E
RQ
F
GQ
M
S
GL
K
Q
MSS
Q
S
SG-
G
ASV
ITL
Q
F
Q
L
TL
P
L
D
V
A
EQ
E
VQ
AA
IN
A
A
TNL
LP
SDLPNP
P
V
YSKVNPADP
---
P
I
MTL
A
VT
S
T--AMPMT
Q
V
E
D
M
V
ETR
V
ARK
I
S
QIS
GVG
L
V
TLS
G
GQRPAV
R
V
K
L
NA
QA
IA
ALG
L
TSET
V
RT
AI
TGA
N
VNSAK
G
S
L
--
-
-
--DGPSRAVT
L
S
A
NDQ
M
Q
S
A
EE
Y
RQ
L
I
I
AYQ-
N
G
AP
I
R
L
G
DVA
T
VE
Q
G
A
E
NSWLG
A
WA
N
K
E
-
Q
A
I
V
MN
V
Q
R
QP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TES
L
P
K
S
VK
VTVL
S
D
R
T
TN
I
RA
S
V
D
D
TQFE
L
M
M
AI
A
LV
V
M
I
I
YLFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
A
V
M
V
F
L
D
F
S
I
N
N
LT
L
M
A
L
T
I
A
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
K
GEK
P
LA
A
AL
K
GAG
E
I
G
F
TI
ISLTFS
L
I
AV
L
IP
L
L
F
MG
D
IV
G
R
LF
R
E
F
A
IT
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRAS
E
KM
F
DRIIAA
----
Y
GRGLA
KVL
NHPWLT
L
S
V
A
L
S
TLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VA
D
--
VILQDPA
V
Q
S
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQ
V
SR
T
QYQFT
L
QAT---SL
D
A
L
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
QD
KGLVAY
VNVD
RD
S
A
S
R
L
G
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
L
E
HNTEN
T
PG
L
AA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SF
N
V
PDNY
S
L
G
D
A
VQAIMDTEKT
L
N
L
P
V
D
ITTQ
F
Q
G
ST
LA
F
Q
SA
L
GS--TVW
L
I
V
-
A
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAE
R
EQ
----------
G
MSPR
EA
IYQ
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
IV
S
Q
V
L
T
L
F
TT
P
VI
Y
L
L
fig|749533.3.peg.436
Escherichia coli MS 84-1 (17-1021/1040)
I
M
RPVA
TTL
L
----
M
V
A
I
L
L
A
G
IIG
Y
RA
LPV
S
AL
P
E
V
DY
P
T
I
Q
V
V
T
L
YPGA
S
PD
V
M
T
S
A
VT
A
PL
E
RQ
F
GQ
M
S
GL
K
Q
MSS
Q
S
SG-
G
ASV
ITL
Q
F
Q
L
TL
P
L
D
V
A
EQ
E
VQ
AA
IN
A
A
TNL
LP
SDLPNP
P
V
YSKVNPADP
---
P
I
MTL
A
VT
S
T--AMPMT
Q
V
E
D
M
V
ETR
V
ARK
I
S
QIS
GVG
L
V
TLS
G
GQRPAV
R
V
K
L
NA
QA
IA
ALG
L
TSET
V
RT
AI
TGA
N
VNSAK
G
S
L
--
-
-
--DGPSRAVT
L
S
A
NDQ
M
Q
S
A
EE
Y
RQ
L
I
I
AYQ-
N
G
AP
I
R
L
G
DVA
T
VE
Q
G
A
E
NSWLG
A
WA
N
K
E
-
Q
A
I
V
MN
V
Q
R
QP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TES
L
P
K
S
VK
VTVL
S
D
R
T
TN
I
RA
S
V
D
D
TQFE
L
M
M
AI
A
LV
V
M
I
I
YLFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
A
V
M
V
F
L
D
F
S
I
N
N
LT
L
M
A
L
T
I
A
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
K
GEK
P
LA
A
AL
K
GAG
E
I
G
F
TI
ISLTFS
L
I
AV
L
IP
L
L
F
MG
D
IV
G
R
LF
R
E
F
A
IT
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRAS
E
KM
F
DRIIAA
----
Y
GRGLA
KVL
NHPWLT
L
S
V
A
L
S
TLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VA
D
--
VILQDPA
V
Q
S
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQ
V
SR
T
QYQFT
L
QAT---SL
D
A
L
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
QD
KGLVAY
VNVD
RD
S
A
S
R
L
G
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
L
E
HNTEN
T
PG
L
AA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SF
N
V
PDNY
S
L
G
D
A
VQAIMDTEKT
L
N
L
P
V
D
ITTQ
F
Q
G
ST
LA
F
Q
SA
L
GS--TVW
L
I
V
-
A
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAE
R
EQ
----------
G
MSPR
EA
IYQ
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
IV
S
Q
V
L
T
L
F
TT
P
VI
Y
L
L
fig|562.373.peg.4607
Escherichia coli 1125A (17-1021/1040)
I
M
RPVA
TTL
L
----
M
V
A
I
L
L
A
G
IIG
Y
RA
LPV
S
AL
P
E
V
DY
P
T
I
Q
V
V
T
L
YPGA
S
PD
V
M
T
S
A
VT
A
PL
E
RQ
F
GQ
M
S
GL
K
Q
MSS
Q
S
SG-
G
ASV
ITL
Q
F
Q
L
TL
P
L
D
V
A
EQ
E
VQ
AA
IN
A
A
TNL
LP
SDLPNP
P
V
YSKVNPADP
---
P
I
MTL
A
VT
S
T--AMPMT
Q
V
E
D
M
V
ETR
V
AQK
I
S
QIS
GVG
L
V
TLS
G
GQRPAV
R
V
K
L
NA
QA
IA
ALG
L
TSET
V
RT
AI
TGA
N
VNSAK
G
S
L
--
-
-
--DGPSRAVT
L
S
A
NDQ
M
Q
S
A
EE
Y
RQ
L
I
I
AYQ-
N
G
AP
I
R
L
G
DVA
T
VE
Q
G
A
E
NSWLG
A
WA
N
K
E
-
Q
A
I
V
MN
V
Q
R
QP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TES
L
P
K
S
VK
VTVL
S
D
R
T
TN
I
RA
S
V
D
D
TQFE
L
M
M
AI
T
LV
V
M
I
I
YLFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
A
V
M
V
F
L
D
F
S
I
N
N
LT
L
M
A
L
T
I
A
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
K
GEK
P
LA
A
AL
K
GAG
E
I
G
F
TI
ISLTFS
L
I
AV
L
IP
L
L
F
MG
D
IV
G
R
LF
R
E
F
A
IT
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRAS
E
KM
F
DRIIAA
----
Y
GRGLA
KVL
NHPWLT
L
S
V
A
L
S
TLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VA
D
--
VILQDPA
V
Q
S
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQ
V
SR
T
QYQFT
L
QAT---SL
D
A
L
STWVP
QL
MEK
L
QQL
P
-Q
I
SD
V
SS
D
W
QD
KGLVAY
VNVD
RD
S
A
S
R
L
G
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
L
E
HNTEN
T
PG
L
AA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SF
N
V
PDNY
S
L
G
D
A
VQAIMDTEKT
L
N
L
P
V
D
ITTQ
F
Q
G
ST
LA
F
Q
SA
L
GS--TVW
L
I
V
-
A
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAE
R
EQ
----------
G
MSPR
D
A
IYQ
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
IV
S
Q
V
L
T
L
F
TT
P
VI
Y
L
L
fig|444454.5.peg.1747
Escherichia coli O157:H7 str. EC4024 (17-1021/1040)
I
M
RPVA
TTL
L
----
M
V
A
I
L
L
A
G
IIG
Y
RA
LPV
S
AL
P
E
V
DY
P
T
I
Q
V
V
T
L
YPGA
S
PD
V
M
T
S
A
VT
A
PL
E
RQ
F
GQ
M
S
GL
K
Q
MSS
Q
S
SG-
G
ASV
ITL
Q
F
Q
L
TL
P
L
D
V
A
EQ
E
VQ
AA
IN
A
A
TNL
LP
SDLPNP
P
V
YSKVNPADP
---
P
I
MTL
A
VT
S
T--AMPMT
Q
V
E
D
M
V
ETR
V
AQK
I
S
QIS
GVG
L
V
TLS
G
GQRPAV
R
V
K
L
NA
QA
IA
ALG
L
TSET
V
RT
AI
TGA
N
VNSAK
G
S
L
--
-
-
--DGPSRAVT
L
S
A
NDQ
M
Q
S
A
EE
Y
RQ
L
I
I
AYQ-
N
G
AP
I
R
L
G
DVA
T
VE
Q
G
A
E
NSWLG
A
WA
N
K
E
-
Q
A
I
V
MN
V
Q
R
QP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TES
L
P
K
S
VK
VTVL
S
D
R
T
TN
I
RA
S
V
D
D
TQFE
L
M
M
AI
T
LV
V
M
I
I
YLFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
A
V
M
V
F
L
D
F
S
I
N
N
LT
L
M
A
L
T
I
A
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
K
GEK
P
LA
A
AL
K
GAG
E
I
G
F
TI
ISLTFS
L
I
AV
L
IP
L
L
F
MG
D
IV
G
R
LF
R
E
F
A
IT
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRAS
E
KM
F
DRIIAA
----
Y
GRGLA
KVL
NHPWLT
L
S
V
A
L
S
TLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VA
D
--
VILQDPA
V
Q
S
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQ
V
SR
T
QYQFT
L
QAT---SL
D
A
L
STWVP
QL
MEK
L
QQL
P
-Q
I
SD
V
SS
D
W
QD
KGLVAY
VNVD
RD
S
A
S
R
L
G
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
L
E
HNTEN
T
PG
L
AA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SF
N
V
PDNY
S
L
G
D
A
VQAIMDTEKT
L
N
L
P
V
D
ITTQ
F
Q
G
ST
LA
F
Q
SA
L
GS--TVW
L
I
V
-
A
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAE
R
EQ
----------
G
MSPR
D
A
IYQ
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
IV
S
Q
V
L
T
L
F
TT
P
VI
Y
L
L
fig|444449.5.peg.1223
Escherichia coli O157:H7 str. EC4042 (17-1021/1040)
I
M
RPVA
TTL
L
----
M
V
A
I
L
L
A
G
IIG
Y
RA
LPV
S
AL
P
E
V
DY
P
T
I
Q
V
V
T
L
YPGA
S
PD
V
M
T
S
A
VT
A
PL
E
RQ
F
GQ
M
S
GL
K
Q
MSS
Q
S
SG-
G
ASV
ITL
Q
F
Q
L
TL
P
L
D
V
A
EQ
E
VQ
AA
IN
A
A
TNL
LP
SDLPNP
P
V
YSKVNPADP
---
P
I
MTL
A
VT
S
T--AMPMT
Q
V
E
D
M
V
ETR
V
AQK
I
S
QIS
GVG
L
V
TLS
G
GQRPAV
R
V
K
L
NA
QA
IA
ALG
L
TSET
V
RT
AI
TGA
N
VNSAK
G
S
L
--
-
-
--DGPSRAVT
L
S
A
NDQ
M
Q
S
A
EE
Y
RQ
L
I
I
AYQ-
N
G
AP
I
R
L
G
DVA
T
VE
Q
G
A
E
NSWLG
A
WA
N
K
E
-
Q
A
I
V
MN
V
Q
R
QP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TES
L
P
K
S
VK
VTVL
S
D
R
T
TN
I
RA
S
V
D
D
TQFE
L
M
M
AI
T
LV
V
M
I
I
YLFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
A
V
M
V
F
L
D
F
S
I
N
N
LT
L
M
A
L
T
I
A
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
K
GEK
P
LA
A
AL
K
GAG
E
I
G
F
TI
ISLTFS
L
I
AV
L
IP
L
L
F
MG
D
IV
G
R
LF
R
E
F
A
IT
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRAS
E
KM
F
DRIIAA
----
Y
GRGLA
KVL
NHPWLT
L
S
V
A
L
S
TLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VA
D
--
VILQDPA
V
Q
S
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQ
V
SR
T
QYQFT
L
QAT---SL
D
A
L
STWVP
QL
MEK
L
QQL
P
-Q
I
SD
V
SS
D
W
QD
KGLVAY
VNVD
RD
S
A
S
R
L
G
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
L
E
HNTEN
T
PG
L
AA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SF
N
V
PDNY
S
L
G
D
A
VQAIMDTEKT
L
N
L
P
V
D
ITTQ
F
Q
G
ST
LA
F
Q
SA
L
GS--TVW
L
I
V
-
A
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAE
R
EQ
----------
G
MSPR
D
A
IYQ
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
IV
S
Q
V
L
T
L
F
TT
P
VI
Y
L
L
fig|444448.5.peg.5497
Escherichia coli O157:H7 str. EC4045 (17-1021/1040)
I
M
RPVA
TTL
L
----
M
V
A
I
L
L
A
G
IIG
Y
RA
LPV
S
AL
P
E
V
DY
P
T
I
Q
V
V
T
L
YPGA
S
PD
V
M
T
S
A
VT
A
PL
E
RQ
F
GQ
M
S
GL
K
Q
MSS
Q
S
SG-
G
ASV
ITL
Q
F
Q
L
TL
P
L
D
V
A
EQ
E
VQ
AA
IN
A
A
TNL
LP
SDLPNP
P
V
YSKVNPADP
---
P
I
MTL
A
VT
S
T--AMPMT
Q
V
E
D
M
V
ETR
V
AQK
I
S
QIS
GVG
L
V
TLS
G
GQRPAV
R
V
K
L
NA
QA
IA
ALG
L
TSET
V
RT
AI
TGA
N
VNSAK
G
S
L
--
-
-
--DGPSRAVT
L
S
A
NDQ
M
Q
S
A
EE
Y
RQ
L
I
I
AYQ-
N
G
AP
I
R
L
G
DVA
T
VE
Q
G
A
E
NSWLG
A
WA
N
K
E
-
Q
A
I
V
MN
V
Q
R
QP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TES
L
P
K
S
VK
VTVL
S
D
R
T
TN
I
RA
S
V
D
D
TQFE
L
M
M
AI
T
LV
V
M
I
I
YLFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
A
V
M
V
F
L
D
F
S
I
N
N
LT
L
M
A
L
T
I
A
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
K
GEK
P
LA
A
AL
K
GAG
E
I
G
F
TI
ISLTFS
L
I
AV
L
IP
L
L
F
MG
D
IV
G
R
LF
R
E
F
A
IT
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRAS
E
KM
F
DRIIAA
----
Y
GRGLA
KVL
NHPWLT
L
S
V
A
L
S
TLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VA
D
--
VILQDPA
V
Q
S
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQ
V
SR
T
QYQFT
L
QAT---SL
D
A
L
STWVP
QL
MEK
L
QQL
P
-Q
I
SD
V
SS
D
W
QD
KGLVAY
VNVD
RD
S
A
S
R
L
G
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
L
E
HNTEN
T
PG
L
AA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SF
N
V
PDNY
S
L
G
D
A
VQAIMDTEKT
L
N
L
P
V
D
ITTQ
F
Q
G
ST
LA
F
Q
SA
L
GS--TVW
L
I
V
-
A
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAE
R
EQ
----------
G
MSPR
D
A
IYQ
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
IV
S
Q
V
L
T
L
F
TT
P
VI
Y
L
L
fig|444453.5.peg.3716
Escherichia coli O157:H7 str. EC4076 (17-1021/1040)
I
M
RPVA
TTL
L
----
M
V
A
I
L
L
A
G
IIG
Y
RA
LPV
S
AL
P
E
V
DY
P
T
I
Q
V
V
T
L
YPGA
S
PD
V
M
T
S
A
VT
A
PL
E
RQ
F
GQ
M
S
GL
K
Q
MSS
Q
S
SG-
G
ASV
ITL
Q
F
Q
L
TL
P
L
D
V
A
EQ
E
VQ
AA
IN
A
A
TNL
LP
SDLPNP
P
V
YSKVNPADP
---
P
I
MTL
A
VT
S
T--AMPMT
Q
V
E
D
M
V
ETR
V
AQK
I
S
QIS
GVG
L
V
TLS
G
GQRPAV
R
V
K
L
NA
QA
IA
ALG
L
TSET
V
RT
AI
TGA
N
VNSAK
G
S
L
--
-
-
--DGPSRAVT
L
S
A
NDQ
M
Q
S
A
EE
Y
RQ
L
I
I
AYQ-
N
G
AP
I
R
L
G
DVA
T
VE
Q
G
A
E
NSWLG
A
WA
N
K
E
-
Q
A
I
V
MN
V
Q
R
QP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TES
L
P
K
S
VK
VTVL
S
D
R
T
TN
I
RA
S
V
D
D
TQFE
L
M
M
AI
T
LV
V
M
I
I
YLFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
A
V
M
V
F
L
D
F
S
I
N
N
LT
L
M
A
L
T
I
A
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
K
GEK
P
LA
A
AL
K
GAG
E
I
G
F
TI
ISLTFS
L
I
AV
L
IP
L
L
F
MG
D
IV
G
R
LF
R
E
F
A
IT
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRAS
E
KM
F
DRIIAA
----
Y
GRGLA
KVL
NHPWLT
L
S
V
A
L
S
TLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VA
D
--
VILQDPA
V
Q
S
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQ
V
SR
T
QYQFT
L
QAT---SL
D
A
L
STWVP
QL
MEK
L
QQL
P
-Q
I
SD
V
SS
D
W
QD
KGLVAY
VNVD
RD
S
A
S
R
L
G
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
L
E
HNTEN
T
PG
L
AA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SF
N
V
PDNY
S
L
G
D
A
VQAIMDTEKT
L
N
L
P
V
D
ITTQ
F
Q
G
ST
LA
F
Q
SA
L
GS--TVW
L
I
V
-
A
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAE
R
EQ
----------
G
MSPR
D
A
IYQ
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
IV
S
Q
V
L
T
L
F
TT
P
VI
Y
L
L
fig|444452.5.peg.3369
Escherichia coli O157:H7 str. EC4113 (17-1021/1040)
I
M
RPVA
TTL
L
----
M
V
A
I
L
L
A
G
IIG
Y
RA
LPV
S
AL
P
E
V
DY
P
T
I
Q
V
V
T
L
YPGA
S
PD
V
M
T
S
A
VT
A
PL
E
RQ
F
GQ
M
S
GL
K
Q
MSS
Q
S
SG-
G
ASV
ITL
Q
F
Q
L
TL
P
L
D
V
A
EQ
E
VQ
AA
IN
A
A
TNL
LP
SDLPNP
P
V
YSKVNPADP
---
P
I
MTL
A
VT
S
T--AMPMT
Q
V
E
D
M
V
ETR
V
AQK
I
S
QIS
GVG
L
V
TLS
G
GQRPAV
R
V
K
L
NA
QA
IA
ALG
L
TSET
V
RT
AI
TGA
N
VNSAK
G
S
L
--
-
-
--DGPSRAVT
L
S
A
NDQ
M
Q
S
A
EE
Y
RQ
L
I
I
AYQ-
N
G
AP
I
R
L
G
DVA
T
VE
Q
G
A
E
NSWLG
A
WA
N
K
E
-
Q
A
I
V
MN
V
Q
R
QP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TES
L
P
K
S
VK
VTVL
S
D
R
T
TN
I
RA
S
V
D
D
TQFE
L
M
M
AI
T
LV
V
M
I
I
YLFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
A
V
M
V
F
L
D
F
S
I
N
N
LT
L
M
A
L
T
I
A
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
K
GEK
P
LA
A
AL
K
GAG
E
I
G
F
TI
ISLTFS
L
I
AV
L
IP
L
L
F
MG
D
IV
G
R
LF
R
E
F
A
IT
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRAS
E
KM
F
DRIIAA
----
Y
GRGLA
KVL
NHPWLT
L
S
V
A
L
S
TLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VA
D
--
VILQDPA
V
Q
S
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQ
V
SR
T
QYQFT
L
QAT---SL
D
A
L
STWVP
QL
MEK
L
QQL
P
-Q
I
SD
V
SS
D
W
QD
KGLVAY
VNVD
RD
S
A
S
R
L
G
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
L
E
HNTEN
T
PG
L
AA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SF
N
V
PDNY
S
L
G
D
A
VQAIMDTEKT
L
N
L
P
V
D
ITTQ
F
Q
G
ST
LA
F
Q
SA
L
GS--TVW
L
I
V
-
A
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAE
R
EQ
----------
G
MSPR
D
A
IYQ
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
IV
S
Q
V
L
T
L
F
TT
P
VI
Y
L
L
fig|444450.8.peg.3017
Escherichia coli O157:H7 str. EC4115 (17-1021/1040)
I
M
RPVA
TTL
L
----
M
V
A
I
L
L
A
G
IIG
Y
RA
LPV
S
AL
P
E
V
DY
P
T
I
Q
V
V
T
L
YPGA
S
PD
V
M
T
S
A
VT
A
PL
E
RQ
F
GQ
M
S
GL
K
Q
MSS
Q
S
SG-
G
ASV
ITL
Q
F
Q
L
TL
P
L
D
V
A
EQ
E
VQ
AA
IN
A
A
TNL
LP
SDLPNP
P
V
YSKVNPADP
---
P
I
MTL
A
VT
S
T--AMPMT
Q
V
E
D
M
V
ETR
V
AQK
I
S
QIS
GVG
L
V
TLS
G
GQRPAV
R
V
K
L
NA
QA
IA
ALG
L
TSET
V
RT
AI
TGA
N
VNSAK
G
S
L
--
-
-
--DGPSRAVT
L
S
A
NDQ
M
Q
S
A
EE
Y
RQ
L
I
I
AYQ-
N
G
AP
I
R
L
G
DVA
T
VE
Q
G
A
E
NSWLG
A
WA
N
K
E
-
Q
A
I
V
MN
V
Q
R
QP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TES
L
P
K
S
VK
VTVL
S
D
R
T
TN
I
RA
S
V
D
D
TQFE
L
M
M
AI
T
LV
V
M
I
I
YLFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
A
V
M
V
F
L
D
F
S
I
N
N
LT
L
M
A
L
T
I
A
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
K
GEK
P
LA
A
AL
K
GAG
E
I
G
F
TI
ISLTFS
L
I
AV
L
IP
L
L
F
MG
D
IV
G
R
LF
R
E
F
A
IT
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRAS
E
KM
F
DRIIAA
----
Y
GRGLA
KVL
NHPWLT
L
S
V
A
L
S
TLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VA
D
--
VILQDPA
V
Q
S
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQ
V
SR
T
QYQFT
L
QAT---SL
D
A
L
STWVP
QL
MEK
L
QQL
P
-Q
I
SD
V
SS
D
W
QD
KGLVAY
VNVD
RD
S
A
S
R
L
G
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
L
E
HNTEN
T
PG
L
AA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SF
N
V
PDNY
S
L
G
D
A
VQAIMDTEKT
L
N
L
P
V
D
ITTQ
F
Q
G
ST
LA
F
Q
SA
L
GS--TVW
L
I
V
-
A
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAE
R
EQ
----------
G
MSPR
D
A
IYQ
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
IV
S
Q
V
L
T
L
F
TT
P
VI
Y
L
L
fig|444451.5.peg.3058
Escherichia coli O157:H7 str. EC4196 (17-1021/1040)
I
M
RPVA
TTL
L
----
M
V
A
I
L
L
A
G
IIG
Y
RA
LPV
S
AL
P
E
V
DY
P
T
I
Q
V
V
T
L
YPGA
S
PD
V
M
T
S
A
VT
A
PL
E
RQ
F
GQ
M
S
GL
K
Q
MSS
Q
S
SG-
G
ASV
ITL
Q
F
Q
L
TL
P
L
D
V
A
EQ
E
VQ
AA
IN
A
A
TNL
LP
SDLPNP
P
V
YSKVNPADP
---
P
I
MTL
A
VT
S
T--AMPMT
Q
V
E
D
M
V
ETR
V
AQK
I
S
QIS
GVG
L
V
TLS
G
GQRPAV
R
V
K
L
NA
QA
IA
ALG
L
TSET
V
RT
AI
TGA
N
VNSAK
G
S
L
--
-
-
--DGPSRAVT
L
S
A
NDQ
M
Q
S
A
EE
Y
RQ
L
I
I
AYQ-
N
G
AP
I
R
L
G
DVA
T
VE
Q
G
A
E
NSWLG
A
WA
N
K
E
-
Q
A
I
V
MN
V
Q
R
QP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TES
L
P
K
S
VK
VTVL
S
D
R
T
TN
I
RA
S
V
D
D
TQFE
L
M
M
AI
T
LV
V
M
I
I
YLFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
A
V
M
V
F
L
D
F
S
I
N
N
LT
L
M
A
L
T
I
A
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
K
GEK
P
LA
A
AL
K
GAG
E
I
G
F
TI
ISLTFS
L
I
AV
L
IP
L
L
F
MG
D
IV
G
R
LF
R
E
F
A
IT
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRAS
E
KM
F
DRIIAA
----
Y
GRGLA
KVL
NHPWLT
L
S
V
A
L
S
TLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VA
D
--
VILQDPA
V
Q
S
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQ
V
SR
T
QYQFT
L
QAT---SL
D
A
L
STWVP
QL
MEK
L
QQL
P
-Q
I
SD
V
SS
D
W
QD
KGLVAY
VNVD
RD
S
A
S
R
L
G
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
L
E
HNTEN
T
PG
L
AA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SF
N
V
PDNY
S
L
G
D
A
VQAIMDTEKT
L
N
L
P
V
D
ITTQ
F
Q
G
ST
LA
F
Q
SA
L
GS--TVW
L
I
V
-
A
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAE
R
EQ
----------
G
MSPR
D
A
IYQ
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
IV
S
Q
V
L
T
L
F
TT
P
VI
Y
L
L
fig|444447.5.peg.118
Escherichia coli O157:H7 str. EC4206 (17-1021/1040)
I
M
RPVA
TTL
L
----
M
V
A
I
L
L
A
G
IIG
Y
RA
LPV
S
AL
P
E
V
DY
P
T
I
Q
V
V
T
L
YPGA
S
PD
V
M
T
S
A
VT
A
PL
E
RQ
F
GQ
M
S
GL
K
Q
MSS
Q
S
SG-
G
ASV
ITL
Q
F
Q
L
TL
P
L
D
V
A
EQ
E
VQ
AA
IN
A
A
TNL
LP
SDLPNP
P
V
YSKVNPADP
---
P
I
MTL
A
VT
S
T--AMPMT
Q
V
E
D
M
V
ETR
V
AQK
I
S
QIS
GVG
L
V
TLS
G
GQRPAV
R
V
K
L
NA
QA
IA
ALG
L
TSET
V
RT
AI
TGA
N
VNSAK
G
S
L
--
-
-
--DGPSRAVT
L
S
A
NDQ
M
Q
S
A
EE
Y
RQ
L
I
I
AYQ-
N
G
AP
I
R
L
G
DVA
T
VE
Q
G
A
E
NSWLG
A
WA
N
K
E
-
Q
A
I
V
MN
V
Q
R
QP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TES
L
P
K
S
VK
VTVL
S
D
R
T
TN
I
RA
S
V
D
D
TQFE
L
M
M
AI
T
LV
V
M
I
I
YLFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
A
V
M
V
F
L
D
F
S
I
N
N
LT
L
M
A
L
T
I
A
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
K
GEK
P
LA
A
AL
K
GAG
E
I
G
F
TI
ISLTFS
L
I
AV
L
IP
L
L
F
MG
D
IV
G
R
LF
R
E
F
A
IT
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRAS
E
KM
F
DRIIAA
----
Y
GRGLA
KVL
NHPWLT
L
S
V
A
L
S
TLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VA
D
--
VILQDPA
V
Q
S
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQ
V
SR
T
QYQFT
L
QAT---SL
D
A
L
STWVP
QL
MEK
L
QQL
P
-Q
I
SD
V
SS
D
W
QD
KGLVAY
VNVD
RD
S
A
S
R
L
G
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
L
E
HNTEN
T
PG
L
AA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SF
N
V
PDNY
S
L
G
D
A
VQAIMDTEKT
L
N
L
P
V
D
ITTQ
F
Q
G
ST
LA
F
Q
SA
L
GS--TVW
L
I
V
-
A
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAE
R
EQ
----------
G
MSPR
D
A
IYQ
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
IV
S
Q
V
L
T
L
F
TT
P
VI
Y
L
L
fig|478004.5.peg.4589
Escherichia coli O157:H7 str. EC4401 (17-1021/1040)
I
M
RPVA
TTL
L
----
M
V
A
I
L
L
A
G
IIG
Y
RA
LPV
S
AL
P
E
V
DY
P
T
I
Q
V
V
T
L
YPGA
S
PD
V
M
T
S
A
VT
A
PL
E
RQ
F
GQ
M
S
GL
K
Q
MSS
Q
S
SG-
G
ASV
ITL
Q
F
Q
L
TL
P
L
D
V
A
EQ
E
VQ
AA
IN
A
A
TNL
LP
SDLPNP
P
V
YSKVNPADP
---
P
I
MTL
A
VT
S
T--AMPMT
Q
V
E
D
M
V
ETR
V
AQK
I
S
QIS
GVG
L
V
TLS
G
GQRPAV
R
V
K
L
NA
QA
IA
ALG
L
TSET
V
RT
AI
TGA
N
VNSAK
G
S
L
--
-
-
--DGPSRAVT
L
S
A
NDQ
M
Q
S
A
EE
Y
RQ
L
I
I
AYQ-
N
G
AP
I
R
L
G
DVA
T
VE
Q
G
A
E
NSWLG
A
WA
N
K
E
-
Q
A
I
V
MN
V
Q
R
QP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TES
L
P
K
S
VK
VTVL
S
D
R
T
TN
I
RA
S
V
D
D
TQFE
L
M
M
AI
T
LV
V
M
I
I
YLFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
A
V
M
V
F
L
D
F
S
I
N
N
LT
L
M
A
L
T
I
A
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
K
GEK
P
LA
A
AL
K
GAG
E
I
G
F
TI
ISLTFS
L
I
AV
L
IP
L
L
F
MG
D
IV
G
R
LF
R
E
F
A
IT
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRAS
E
KM
F
DRIIAA
----
Y
GRGLA
KVL
NHPWLT
L
S
V
A
L
S
TLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VA
D
--
VILQDPA
V
Q
S
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQ
V
SR
T
QYQFT
L
QAT---SL
D
A
L
STWVP
QL
MEK
L
QQL
P
-Q
I
SD
V
SS
D
W
QD
KGLVAY
VNVD
RD
S
A
S
R
L
G
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
L
E
HNTEN
T
PG
L
AA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SF
N
V
PDNY
S
L
G
D
A
VQAIMDTEKT
L
N
L
P
V
D
ITTQ
F
Q
G
ST
LA
F
Q
SA
L
GS--TVW
L
I
V
-
A
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAE
R
EQ
----------
G
MSPR
D
A
IYQ
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
IV
S
Q
V
L
T
L
F
TT
P
VI
Y
L
L
fig|478007.5.peg.1817
Escherichia coli O157:H7 str. EC508 (17-1021/1040)
I
M
RPVA
TTL
L
----
M
V
A
I
L
L
A
G
IIG
Y
RA
LPV
S
AL
P
E
V
DY
P
T
I
Q
V
V
T
L
YPGA
S
PD
V
M
T
S
A
VT
A
PL
E
RQ
F
GQ
M
S
GL
K
Q
MSS
Q
S
SG-
G
ASV
ITL
Q
F
Q
L
TL
P
L
D
V
A
EQ
E
VQ
AA
IN
A
A
TNL
LP
SDLPNP
P
V
YSKVNPADP
---
P
I
MTL
A
VT
S
T--AMPMT
Q
V
E
D
M
V
ETR
V
AQK
I
S
QIS
GVG
L
V
TLS
G
GQRPAV
R
V
K
L
NA
QA
IA
ALG
L
TSET
V
RT
AI
TGA
N
VNSAK
G
S
L
--
-
-
--DGPSRAVT
L
S
A
NDQ
M
Q
S
A
EE
Y
RQ
L
I
I
AYQ-
N
G
AP
I
R
L
G
DVA
T
VE
Q
G
A
E
NSWLG
A
WA
N
K
E
-
Q
A
I
V
MN
V
Q
R
QP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TES
L
P
K
S
VK
VTVL
S
D
R
T
TN
I
RA
S
V
D
D
TQFE
L
M
M
AI
T
LV
V
M
I
I
YLFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
A
V
M
V
F
L
D
F
S
I
N
N
LT
L
M
A
L
T
I
A
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
K
GEK
P
LA
A
AL
K
GAG
E
I
G
F
TI
ISLTFS
L
I
AV
L
IP
L
L
F
MG
D
IV
G
R
LF
R
E
F
A
IT
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRAS
E
KM
F
DRIIAA
----
Y
GRGLA
KVL
NHPWLT
L
S
V
A
L
S
TLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VA
D
--
VILQDPA
V
Q
S
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQ
V
SR
T
QYQFT
L
QAT---SL
D
A
L
STWVP
QL
MEK
L
QQL
P
-Q
I
SD
V
SS
D
W
QD
KGLVAY
VNVD
RD
S
A
S
R
L
G
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
L
E
HNTEN
T
PG
L
AA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SF
N
V
PDNY
S
L
G
D
A
VQAIMDTEKT
L
N
L
P
V
D
ITTQ
F
Q
G
ST
LA
F
Q
SA
L
GS--TVW
L
I
V
-
A
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAE
R
EQ
----------
G
MSPR
D
A
IYQ
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
IV
S
Q
V
L
T
L
F
TT
P
VI
Y
L
L
fig|544404.4.peg.2879
Escherichia coli O157:H7 str. TW14359 (17-1021/1040)
I
M
RPVA
TTL
L
----
M
V
A
I
L
L
A
G
IIG
Y
RA
LPV
S
AL
P
E
V
DY
P
T
I
Q
V
V
T
L
YPGA
S
PD
V
M
T
S
A
VT
A
PL
E
RQ
F
GQ
M
S
GL
K
Q
MSS
Q
S
SG-
G
ASV
ITL
Q
F
Q
L
TL
P
L
D
V
A
EQ
E
VQ
AA
IN
A
A
TNL
LP
SDLPNP
P
V
YSKVNPADP
---
P
I
MTL
A
VT
S
T--AMPMT
Q
V
E
D
M
V
ETR
V
AQK
I
S
QIS
GVG
L
V
TLS
G
GQRPAV
R
V
K
L
NA
QA
IA
ALG
L
TSET
V
RT
AI
TGA
N
VNSAK
G
S
L
--
-
-
--DGPSRAVT
L
S
A
NDQ
M
Q
S
A
EE
Y
RQ
L
I
I
AYQ-
N
G
AP
I
R
L
G
DVA
T
VE
Q
G
A
E
NSWLG
A
WA
N
K
E
-
Q
A
I
V
MN
V
Q
R
QP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TES
L
P
K
S
VK
VTVL
S
D
R
T
TN
I
RA
S
V
D
D
TQFE
L
M
M
AI
T
LV
V
M
I
I
YLFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
A
V
M
V
F
L
D
F
S
I
N
N
LT
L
M
A
L
T
I
A
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
K
GEK
P
LA
A
AL
K
GAG
E
I
G
F
TI
ISLTFS
L
I
AV
L
IP
L
L
F
MG
D
IV
G
R
LF
R
E
F
A
IT
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRAS
E
KM
F
DRIIAA
----
Y
GRGLA
KVL
NHPWLT
L
S
V
A
L
S
TLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VA
D
--
VILQDPA
V
Q
S
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQ
V
SR
T
QYQFT
L
QAT---SL
D
A
L
STWVP
QL
MEK
L
QQL
P
-Q
I
SD
V
SS
D
W
QD
KGLVAY
VNVD
RD
S
A
S
R
L
G
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
L
E
HNTEN
T
PG
L
AA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SF
N
V
PDNY
S
L
G
D
A
VQAIMDTEKT
L
N
L
P
V
D
ITTQ
F
Q
G
ST
LA
F
Q
SA
L
GS--TVW
L
I
V
-
A
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAE
R
EQ
----------
G
MSPR
D
A
IYQ
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
IV
S
Q
V
L
T
L
F
TT
P
VI
Y
L
L
fig|749538.3.peg.1296
Escherichia coli MS 116-1 (17-1021/1040)
I
M
RPVA
TTL
L
----
M
V
A
I
L
L
A
G
IIG
Y
RA
LP
I
S
AL
P
E
V
DY
P
T
I
Q
V
V
T
L
YPGA
S
PD
V
M
T
S
A
VT
A
PL
E
RQ
F
GQ
M
S
GL
K
Q
MSS
Q
S
SG-
G
ASV
ITL
Q
F
Q
L
TL
P
L
D
V
A
EQ
E
VQ
AA
IN
A
A
TNL
LP
SDLPNP
P
V
YSKVNPADP
---
P
I
MTL
A
VT
S
T--AMPMT
Q
V
E
D
M
V
ETR
V
AQK
I
S
QIS
GVG
L
V
TLS
G
GQRPAV
R
V
K
L
NA
QA
IA
ALG
L
TSET
V
RT
AI
TGA
N
VNSAK
G
S
L
--
-
-
--DGPSRAVT
L
S
A
NDQ
M
Q
S
A
EE
Y
RQ
L
I
I
AYQ-
N
G
AP
I
R
L
G
DVA
T
VE
Q
G
A
E
NSWLG
A
WA
N
K
E
-
Q
A
I
V
MN
V
Q
R
QP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TES
L
P
K
S
VK
VTVL
S
D
R
T
TN
I
RA
S
V
D
D
TQFE
L
M
M
AI
A
LV
V
M
I
I
YLFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
A
V
M
V
F
L
D
F
S
I
N
N
LT
L
M
A
L
T
I
A
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
K
GEK
P
LA
A
AL
K
GAG
E
I
G
F
TI
ISLTFS
L
I
AV
L
IP
L
L
F
MG
D
IV
G
R
LF
R
E
F
A
IT
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRAS
E
KM
F
DRIIAA
----
Y
GRGLA
KVL
NHPWLT
L
S
V
A
L
S
TLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VA
D
--
VILQDPA
V
Q
S
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQ
V
SR
T
QYQFT
L
QAT---SL
D
A
L
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
QD
KGLVAY
VNVD
RD
S
A
S
R
L
G
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
L
E
HNTEN
T
PG
L
AA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SF
N
V
PDNY
S
L
G
D
A
VQAIMDTEKT
L
N
L
P
V
D
ITTQ
F
Q
G
ST
LA
F
Q
SA
L
GS--TVW
L
I
V
-
A
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAE
R
EQ
----------
G
MSPR
EA
IYQ
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
IV
S
Q
V
L
T
L
F
TT
P
VI
Y
L
L
fig|331112.3.peg.2073
Escherichia coli HS (17-1021/1040)
I
M
RPVA
TTL
L
----
M
V
A
I
L
L
A
G
IIG
Y
RA
LPV
S
AL
P
E
V
DY
P
T
I
Q
V
V
T
L
YPGA
S
PD
V
M
T
S
A
VT
A
PL
E
RQ
F
GQ
M
S
GL
K
Q
MSS
Q
S
SG-
G
ASV
ITL
Q
F
Q
L
TL
P
L
D
V
A
EQ
E
VQ
AA
IN
A
A
TNL
LP
SDLPNP
P
V
YSKVNPADP
---
P
I
MTL
A
VT
S
I--AMPMT
Q
V
E
D
M
V
ETR
V
AQK
I
S
QIS
GVG
L
V
TLS
G
GQRPAV
R
V
K
L
NA
QA
IA
ALG
L
TSET
V
RT
AI
TGA
N
VNSAK
G
S
L
--
-
-
--DGPSRAVT
L
S
A
NDQ
M
Q
S
A
EE
Y
RQ
L
I
I
AYQ-
N
G
AP
I
R
L
G
DVA
T
VE
Q
G
A
E
NSWLG
A
WA
N
K
E
-
Q
A
I
V
MN
V
Q
R
QP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TES
L
P
K
S
VK
VTVL
S
D
R
T
TN
I
RA
S
V
D
D
TQFE
L
M
M
AI
A
LV
V
M
I
I
YLFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
A
V
M
V
F
L
D
F
S
I
N
N
LT
L
M
A
L
T
I
A
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
K
GEK
P
LA
A
AL
K
GAG
E
I
G
F
TI
ISLTFS
L
I
AV
L
IP
L
L
F
MG
D
IV
G
R
LF
R
E
F
A
IT
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRAS
E
KM
F
DRIIAA
----
Y
GRGLA
KVL
NHPWLT
L
S
V
A
L
S
TLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VA
D
--
VILQDPA
V
Q
S
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQ
V
SR
T
QYQFT
L
QAT---SL
D
A
L
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
QD
KGLVAY
VNVD
RD
S
A
S
R
L
G
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
L
E
HNTEN
T
PG
L
AA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SF
N
V
PDNY
S
L
G
D
A
VQAIMDTEKT
L
N
L
P
V
D
ITTQ
F
Q
G
ST
LA
F
Q
SA
L
GS--TVW
L
I
V
-
A
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAE
R
EQ
----------
G
MSPR
EA
IYQ
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
IV
S
Q
V
L
T
L
F
TT
P
VI
Y
L
L
fig|331112.6.peg.2168
Escherichia coli HS (17-1021/1040)
I
M
RPVA
TTL
L
----
M
V
A
I
L
L
A
G
IIG
Y
RA
LPV
S
AL
P
E
V
DY
P
T
I
Q
V
V
T
L
YPGA
S
PD
V
M
T
S
A
VT
A
PL
E
RQ
F
GQ
M
S
GL
K
Q
MSS
Q
S
SG-
G
ASV
ITL
Q
F
Q
L
TL
P
L
D
V
A
EQ
E
VQ
AA
IN
A
A
TNL
LP
SDLPNP
P
V
YSKVNPADP
---
P
I
MTL
A
VT
S
I--AMPMT
Q
V
E
D
M
V
ETR
V
AQK
I
S
QIS
GVG
L
V
TLS
G
GQRPAV
R
V
K
L
NA
QA
IA
ALG
L
TSET
V
RT
AI
TGA
N
VNSAK
G
S
L
--
-
-
--DGPSRAVT
L
S
A
NDQ
M
Q
S
A
EE
Y
RQ
L
I
I
AYQ-
N
G
AP
I
R
L
G
DVA
T
VE
Q
G
A
E
NSWLG
A
WA
N
K
E
-
Q
A
I
V
MN
V
Q
R
QP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TES
L
P
K
S
VK
VTVL
S
D
R
T
TN
I
RA
S
V
D
D
TQFE
L
M
M
AI
A
LV
V
M
I
I
YLFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
A
V
M
V
F
L
D
F
S
I
N
N
LT
L
M
A
L
T
I
A
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
K
GEK
P
LA
A
AL
K
GAG
E
I
G
F
TI
ISLTFS
L
I
AV
L
IP
L
L
F
MG
D
IV
G
R
LF
R
E
F
A
IT
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRAS
E
KM
F
DRIIAA
----
Y
GRGLA
KVL
NHPWLT
L
S
V
A
L
S
TLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VA
D
--
VILQDPA
V
Q
S
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQ
V
SR
T
QYQFT
L
QAT---SL
D
A
L
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
QD
KGLVAY
VNVD
RD
S
A
S
R
L
G
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
L
E
HNTEN
T
PG
L
AA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SF
N
V
PDNY
S
L
G
D
A
VQAIMDTEKT
L
N
L
P
V
D
ITTQ
F
Q
G
ST
LA
F
Q
SA
L
GS--TVW
L
I
V
-
A
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAE
R
EQ
----------
G
MSPR
EA
IYQ
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
IV
S
Q
V
L
T
L
F
TT
P
VI
Y
L
L
fig|562.371.peg.4280
Escherichia coli 1044A (17-1021/1040)
I
M
RPVA
TTL
L
----
M
V
A
I
L
L
A
G
IIG
Y
RA
LPV
S
AL
P
E
V
DY
P
T
I
Q
V
V
T
L
YPGA
S
PD
V
M
T
S
A
VT
A
PL
E
RQ
F
GQ
M
S
GL
K
Q
MSS
Q
S
SG-
G
ASV
ITL
Q
F
Q
L
TL
P
L
D
V
A
EQ
E
VQ
AA
IN
A
A
TNL
LP
SDLPNP
P
V
YSKVNPADP
---
P
I
MTL
A
VT
S
T--AMPMT
Q
V
E
D
M
V
ETR
V
AQK
I
S
QIS
GVG
L
V
TLS
G
GQRPAV
R
V
K
L
NA
QA
IA
ALG
L
TSET
V
RT
AI
TGA
N
VNSAK
G
S
L
--
-
-
--DGPSRAVT
L
S
A
NDQ
M
Q
S
A
EE
Y
RQ
L
I
I
AYQ-
N
G
AP
I
R
L
G
DVA
T
VE
Q
G
A
E
NSWLG
A
WA
N
K
E
-
Q
A
I
V
MN
V
Q
R
QP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TES
L
P
K
S
VK
VTVL
S
D
R
T
TN
I
RA
S
V
D
D
TQFE
L
M
M
AI
A
LV
V
M
I
I
YLFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
A
V
M
V
F
L
D
F
S
I
N
N
LT
L
M
A
L
T
I
A
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
K
GEK
P
LA
A
AL
K
GAG
E
I
G
F
TI
ISLTFS
L
I
AV
L
IP
L
L
F
MG
D
IV
G
R
LF
R
E
F
A
IT
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRAS
E
KM
F
DRIIAA
----
Y
GRGLA
KVL
NHPWLT
L
S
V
A
L
S
TLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VA
D
--
VILQDPA
V
Q
S
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQ
V
SR
T
QYQFT
L
QAT---SL
D
A
L
STWVP
QL
MEK
L
QQL
P
-Q
I
SD
V
SS
D
W
QD
KGLVAY
VNVD
RD
S
A
S
R
L
G
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
L
E
HNTEN
T
PG
L
AA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SF
N
V
PDNY
S
L
G
D
A
VQAIMDTEKT
L
N
L
P
V
D
ITTQ
F
Q
G
ST
LA
F
Q
SA
L
GS--TVW
L
I
V
-
A
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAE
R
EQ
----------
G
MSPR
D
A
IYQ
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
IV
S
Q
V
L
T
L
F
TT
P
VI
Y
L
L
fig|562.372.peg.5780
Escherichia coli 1212A (17-1021/1040)
I
M
RPVA
TTL
L
----
M
V
A
I
L
L
A
G
IIG
Y
RA
LPV
S
AL
P
E
V
DY
P
T
I
Q
V
V
T
L
YPGA
S
PD
V
M
T
S
A
VT
A
PL
E
RQ
F
GQ
M
S
GL
K
Q
MSS
Q
S
SG-
G
ASV
ITL
Q
F
Q
L
TL
P
L
D
V
A
EQ
E
VQ
AA
IN
A
A
TNL
LP
SDLPNP
P
V
YSKVNPADP
---
P
I
MTL
A
VT
S
T--AMPMT
Q
V
E
D
M
V
ETR
V
AQK
I
S
QIS
GVG
L
V
TLS
G
GQRPAV
R
V
K
L
NA
QA
IA
ALG
L
TSET
V
RT
AI
TGA
N
VNSAK
G
S
L
--
-
-
--DGPSRAVT
L
S
A
NDQ
M
Q
S
A
EE
Y
RQ
L
I
I
AYQ-
N
G
AP
I
R
L
G
DVA
T
VE
Q
G
A
E
NSWLG
A
WA
N
K
E
-
Q
A
I
V
MN
V
Q
R
QP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TES
L
P
K
S
VK
VTVL
S
D
R
T
TN
I
RA
S
V
D
D
TQFE
L
M
M
AI
A
LV
V
M
I
I
YLFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
A
V
M
V
F
L
D
F
S
I
N
N
LT
L
M
A
L
T
I
A
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
K
GEK
P
LA
A
AL
K
GAG
E
I
G
F
TI
ISLTFS
L
I
AV
L
IP
L
L
F
MG
D
IV
G
R
LF
R
E
F
A
IT
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRAS
E
KM
F
DRIIAA
----
Y
GRGLA
KVL
NHPWLT
L
S
V
A
L
S
TLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VA
D
--
VILQDPA
V
Q
S
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQ
V
SR
T
QYQFT
L
QAT---SL
D
A
L
STWVP
QL
MEK
L
QQL
P
-Q
I
SD
V
SS
D
W
QD
KGLVAY
VNVD
RD
S
A
S
R
L
G
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
L
E
HNTEN
T
PG
L
AA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SF
N
V
PDNY
S
L
G
D
A
VQAIMDTEKT
L
N
L
P
V
D
ITTQ
F
Q
G
ST
LA
F
Q
SA
L
GS--TVW
L
I
V
-
A
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAE
R
EQ
----------
G
MSPR
D
A
IYQ
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
IV
S
Q
V
L
T
L
F
TT
P
VI
Y
L
L
fig|562.374.peg.1790
Escherichia coli 536A (17-1021/1040)
I
M
RPVA
TTL
L
----
M
V
A
I
L
L
A
G
IIG
Y
RA
LPV
S
AL
P
E
V
DY
P
T
I
Q
V
V
T
L
YPGA
S
PD
V
M
T
S
A
VT
A
PL
E
RQ
F
GQ
M
S
GL
K
Q
MSS
Q
S
SG-
G
ASV
ITL
Q
F
Q
L
TL
P
L
D
V
A
EQ
E
VQ
AA
IN
A
A
TNL
LP
SDLPNP
P
V
YSKVNPADP
---
P
I
MTL
A
VT
S
T--AMPMT
Q
V
E
D
M
V
ETR
V
AQK
I
S
QIS
GVG
L
V
TLS
G
GQRPAV
R
V
K
L
NA
QA
IA
ALG
L
TSET
V
RT
AI
TGA
N
VNSAK
G
S
L
--
-
-
--DGPSRAVT
L
S
A
NDQ
M
Q
S
A
EE
Y
RQ
L
I
I
AYQ-
N
G
AP
I
R
L
G
DVA
T
VE
Q
G
A
E
NSWLG
A
WA
N
K
E
-
Q
A
I
V
MN
V
Q
R
QP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TES
L
P
K
S
VK
VTVL
S
D
R
T
TN
I
RA
S
V
D
D
TQFE
L
M
M
AI
A
LV
V
M
I
I
YLFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
A
V
M
V
F
L
D
F
S
I
N
N
LT
L
M
A
L
T
I
A
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
K
GEK
P
LA
A
AL
K
GAG
E
I
G
F
TI
ISLTFS
L
I
AV
L
IP
L
L
F
MG
D
IV
G
R
LF
R
E
F
A
IT
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRAS
E
KM
F
DRIIAA
----
Y
GRGLA
KVL
NHPWLT
L
S
V
A
L
S
TLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VA
D
--
VILQDPA
V
Q
S
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQ
V
SR
T
QYQFT
L
QAT---SL
D
A
L
STWVP
QL
MEK
L
QQL
P
-Q
I
SD
V
SS
D
W
QD
KGLVAY
VNVD
RD
S
A
S
R
L
G
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
L
E
HNTEN
T
PG
L
AA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SF
N
V
PDNY
S
L
G
D
A
VQAIMDTEKT
L
N
L
P
V
D
ITTQ
F
Q
G
ST
LA
F
Q
SA
L
GS--TVW
L
I
V
-
A
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAE
R
EQ
----------
G
MSPR
D
A
IYQ
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
IV
S
Q
V
L
T
L
F
TT
P
VI
Y
L
L
fig|83334.1.peg.2887
Escherichia coli O157:H7 (17-1021/1040)
I
M
RPVA
TTL
L
----
M
V
A
I
L
L
A
G
IIG
Y
RA
LPV
S
AL
P
E
V
DY
P
T
I
Q
V
V
T
L
YPGA
S
PD
V
M
T
S
A
VT
A
PL
E
RQ
F
GQ
M
S
GL
K
Q
MSS
Q
S
SG-
G
ASV
ITL
Q
F
Q
L
TL
P
L
D
V
A
EQ
E
VQ
AA
IN
A
A
TNL
LP
SDLPNP
P
V
YSKVNPADP
---
P
I
MTL
A
VT
S
T--AMPMT
Q
V
E
D
M
V
ETR
V
AQK
I
S
QIS
GVG
L
V
TLS
G
GQRPAV
R
V
K
L
NA
QA
IA
ALG
L
TSET
V
RT
AI
TGA
N
VNSAK
G
S
L
--
-
-
--DGPSRAVT
L
S
A
NDQ
M
Q
S
A
EE
Y
RQ
L
I
I
AYQ-
N
G
AP
I
R
L
G
DVA
T
VE
Q
G
A
E
NSWLG
A
WA
N
K
E
-
Q
A
I
V
MN
V
Q
R
QP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TES
L
P
K
S
VK
VTVL
S
D
R
T
TN
I
RA
S
V
D
D
TQFE
L
M
M
AI
A
LV
V
M
I
I
YLFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
A
V
M
V
F
L
D
F
S
I
N
N
LT
L
M
A
L
T
I
A
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
K
GEK
P
LA
A
AL
K
GAG
E
I
G
F
TI
ISLTFS
L
I
AV
L
IP
L
L
F
MG
D
IV
G
R
LF
R
E
F
A
IT
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRAS
E
KM
F
DRIIAA
----
Y
GRGLA
KVL
NHPWLT
L
S
V
A
L
S
TLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VA
D
--
VILQDPA
V
Q
S
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQ
V
SR
T
QYQFT
L
QAT---SL
D
A
L
STWVP
QL
MEK
L
QQL
P
-Q
I
SD
V
SS
D
W
QD
KGLVAY
VNVD
RD
S
A
S
R
L
G
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
L
E
HNTEN
T
PG
L
AA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SF
N
V
PDNY
S
L
G
D
A
VQAIMDTEKT
L
N
L
P
V
D
ITTQ
F
Q
G
ST
LA
F
Q
SA
L
GS--TVW
L
I
V
-
A
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAE
R
EQ
----------
G
MSPR
D
A
IYQ
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
IV
S
Q
V
L
T
L
F
TT
P
VI
Y
L
L
fig|155864.1.peg.2891
Escherichia coli O157:H7 EDL933 (17-1021/1040)
I
M
RPVA
TTL
L
----
M
V
A
I
L
L
A
G
IIG
Y
RA
LPV
S
AL
P
E
V
DY
P
T
I
Q
V
V
T
L
YPGA
S
PD
V
M
T
S
A
VT
A
PL
E
RQ
F
GQ
M
S
GL
K
Q
MSS
Q
S
SG-
G
ASV
ITL
Q
F
Q
L
TL
P
L
D
V
A
EQ
E
VQ
AA
IN
A
A
TNL
LP
SDLPNP
P
V
YSKVNPADP
---
P
I
MTL
A
VT
S
T--AMPMT
Q
V
E
D
M
V
ETR
V
AQK
I
S
QIS
GVG
L
V
TLS
G
GQRPAV
R
V
K
L
NA
QA
IA
ALG
L
TSET
V
RT
AI
TGA
N
VNSAK
G
S
L
--
-
-
--DGPSRAVT
L
S
A
NDQ
M
Q
S
A
EE
Y
RQ
L
I
I
AYQ-
N
G
AP
I
R
L
G
DVA
T
VE
Q
G
A
E
NSWLG
A
WA
N
K
E
-
Q
A
I
V
MN
V
Q
R
QP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TES
L
P
K
S
VK
VTVL
S
D
R
T
TN
I
RA
S
V
D
D
TQFE
L
M
M
AI
A
LV
V
M
I
I
YLFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
A
V
M
V
F
L
D
F
S
I
N
N
LT
L
M
A
L
T
I
A
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
K
GEK
P
LA
A
AL
K
GAG
E
I
G
F
TI
ISLTFS
L
I
AV
L
IP
L
L
F
MG
D
IV
G
R
LF
R
E
F
A
IT
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRAS
E
KM
F
DRIIAA
----
Y
GRGLA
KVL
NHPWLT
L
S
V
A
L
S
TLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VA
D
--
VILQDPA
V
Q
S
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQ
V
SR
T
QYQFT
L
QAT---SL
D
A
L
STWVP
QL
MEK
L
QQL
P
-Q
I
SD
V
SS
D
W
QD
KGLVAY
VNVD
RD
S
A
S
R
L
G
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
L
E
HNTEN
T
PG
L
AA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SF
N
V
PDNY
S
L
G
D
A
VQAIMDTEKT
L
N
L
P
V
D
ITTQ
F
Q
G
ST
LA
F
Q
SA
L
GS--TVW
L
I
V
-
A
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAE
R
EQ
----------
G
MSPR
D
A
IYQ
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
IV
S
Q
V
L
T
L
F
TT
P
VI
Y
L
L
fig|155864.8.peg.2775
Escherichia coli O157:H7 EDL933 (17-1021/1040)
I
M
RPVA
TTL
L
----
M
V
A
I
L
L
A
G
IIG
Y
RA
LPV
S
AL
P
E
V
DY
P
T
I
Q
V
V
T
L
YPGA
S
PD
V
M
T
S
A
VT
A
PL
E
RQ
F
GQ
M
S
GL
K
Q
MSS
Q
S
SG-
G
ASV
ITL
Q
F
Q
L
TL
P
L
D
V
A
EQ
E
VQ
AA
IN
A
A
TNL
LP
SDLPNP
P
V
YSKVNPADP
---
P
I
MTL
A
VT
S
T--AMPMT
Q
V
E
D
M
V
ETR
V
AQK
I
S
QIS
GVG
L
V
TLS
G
GQRPAV
R
V
K
L
NA
QA
IA
ALG
L
TSET
V
RT
AI
TGA
N
VNSAK
G
S
L
--
-
-
--DGPSRAVT
L
S
A
NDQ
M
Q
S
A
EE
Y
RQ
L
I
I
AYQ-
N
G
AP
I
R
L
G
DVA
T
VE
Q
G
A
E
NSWLG
A
WA
N
K
E
-
Q
A
I
V
MN
V
Q
R
QP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TES
L
P
K
S
VK
VTVL
S
D
R
T
TN
I
RA
S
V
D
D
TQFE
L
M
M
AI
A
LV
V
M
I
I
YLFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
A
V
M
V
F
L
D
F
S
I
N
N
LT
L
M
A
L
T
I
A
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
K
GEK
P
LA
A
AL
K
GAG
E
I
G
F
TI
ISLTFS
L
I
AV
L
IP
L
L
F
MG
D
IV
G
R
LF
R
E
F
A
IT
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRAS
E
KM
F
DRIIAA
----
Y
GRGLA
KVL
NHPWLT
L
S
V
A
L
S
TLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VA
D
--
VILQDPA
V
Q
S
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQ
V
SR
T
QYQFT
L
QAT---SL
D
A
L
STWVP
QL
MEK
L
QQL
P
-Q
I
SD
V
SS
D
W
QD
KGLVAY
VNVD
RD
S
A
S
R
L
G
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
L
E
HNTEN
T
PG
L
AA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SF
N
V
PDNY
S
L
G
D
A
VQAIMDTEKT
L
N
L
P
V
D
ITTQ
F
Q
G
ST
LA
F
Q
SA
L
GS--TVW
L
I
V
-
A
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAE
R
EQ
----------
G
MSPR
D
A
IYQ
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
IV
S
Q
V
L
T
L
F
TT
P
VI
Y
L
L
fig|478006.5.peg.2302
Escherichia coli O157:H7 str. EC4501 (17-1021/1040)
I
M
RPVA
TTL
L
----
M
V
A
I
L
L
A
G
IIG
Y
RA
LPV
S
AL
P
E
V
DY
P
T
I
Q
V
V
T
L
YPGA
S
PD
V
M
T
S
A
VT
A
PL
E
RQ
F
GQ
M
S
GL
K
Q
MSS
Q
S
SG-
G
ASV
ITL
Q
F
Q
L
TL
P
L
D
V
A
EQ
E
VQ
AA
IN
A
A
TNL
LP
SDLPNP
P
V
YSKVNPADP
---
P
I
MTL
A
VT
S
T--AMPMT
Q
V
E
D
M
V
ETR
V
AQK
I
S
QIS
GVG
L
V
TLS
G
GQRPAV
R
V
K
L
NA
QA
IA
ALG
L
TSET
V
RT
AI
TGA
N
VNSAK
G
S
L
--
-
-
--DGPSRAVT
L
S
A
NDQ
M
Q
S
A
EE
Y
RQ
L
I
I
AYQ-
N
G
AP
I
R
L
G
DVA
T
VE
Q
G
A
E
NSWLG
A
WA
N
K
E
-
Q
A
I
V
MN
V
Q
R
QP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TES
L
P
K
S
VK
VTVL
S
D
R
T
TN
I
RA
S
V
D
D
TQFE
L
M
M
AI
A
LV
V
M
I
I
YLFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
A
V
M
V
F
L
D
F
S
I
N
N
LT
L
M
A
L
T
I
A
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
K
GEK
P
LA
A
AL
K
GAG
E
I
G
F
TI
ISLTFS
L
I
AV
L
IP
L
L
F
MG
D
IV
G
R
LF
R
E
F
A
IT
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRAS
E
KM
F
DRIIAA
----
Y
GRGLA
KVL
NHPWLT
L
S
V
A
L
S
TLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VA
D
--
VILQDPA
V
Q
S
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQ
V
SR
T
QYQFT
L
QAT---SL
D
A
L
STWVP
QL
MEK
L
QQL
P
-Q
I
SD
V
SS
D
W
QD
KGLVAY
VNVD
RD
S
A
S
R
L
G
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
L
E
HNTEN
T
PG
L
AA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SF
N
V
PDNY
S
L
G
D
A
VQAIMDTEKT
L
N
L
P
V
D
ITTQ
F
Q
G
ST
LA
F
Q
SA
L
GS--TVW
L
I
V
-
A
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAE
R
EQ
----------
G
MSPR
D
A
IYQ
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
IV
S
Q
V
L
T
L
F
TT
P
VI
Y
L
L
fig|478008.5.peg.3901
Escherichia coli O157:H7 str. EC869 (17-1021/1040)
I
M
RPVA
TTL
L
----
M
V
A
I
L
L
A
G
IIG
Y
RA
LPV
S
AL
P
E
V
DY
P
T
I
Q
V
V
T
L
YPGA
S
PD
V
M
T
S
A
VT
A
PL
E
RQ
F
GQ
M
S
GL
K
Q
MSS
Q
S
SG-
G
ASV
ITL
Q
F
Q
L
TL
P
L
D
V
A
EQ
E
VQ
AA
IN
A
A
TNL
LP
SDLPNP
P
V
YSKVNPADP
---
P
I
MTL
A
VT
S
T--AMPMT
Q
V
E
D
M
V
ETR
V
AQK
I
S
QIS
GVG
L
V
TLS
G
GQRPAV
R
V
K
L
NA
QA
IA
ALG
L
TSET
V
RT
AI
TGA
N
VNSAK
G
S
L
--
-
-
--DGPSRAVT
L
S
A
NDQ
M
Q
S
A
EE
Y
RQ
L
I
I
AYQ-
N
G
AP
I
R
L
G
DVA
T
VE
Q
G
A
E
NSWLG
A
WA
N
K
E
-
Q
A
I
V
MN
V
Q
R
QP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TES
L
P
K
S
VK
VTVL
S
D
R
T
TN
I
RA
S
V
D
D
TQFE
L
M
M
AI
A
LV
V
M
I
I
YLFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
A
V
M
V
F
L
D
F
S
I
N
N
LT
L
M
A
L
T
I
A
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
K
GEK
P
LA
A
AL
K
GAG
E
I
G
F
TI
ISLTFS
L
I
AV
L
IP
L
L
F
MG
D
IV
G
R
LF
R
E
F
A
IT
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRAS
E
KM
F
DRIIAA
----
Y
GRGLA
KVL
NHPWLT
L
S
V
A
L
S
TLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VA
D
--
VILQDPA
V
Q
S
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQ
V
SR
T
QYQFT
L
QAT---SL
D
A
L
STWVP
QL
MEK
L
QQL
P
-Q
I
SD
V
SS
D
W
QD
KGLVAY
VNVD
RD
S
A
S
R
L
G
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
L
E
HNTEN
T
PG
L
AA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SF
N
V
PDNY
S
L
G
D
A
VQAIMDTEKT
L
N
L
P
V
D
ITTQ
F
Q
G
ST
LA
F
Q
SA
L
GS--TVW
L
I
V
-
A
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAE
R
EQ
----------
G
MSPR
D
A
IYQ
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
IV
S
Q
V
L
T
L
F
TT
P
VI
Y
L
L
fig|637388.3.peg.2194
Escherichia coli O157:H7 str. FRIK2000 (17-1021/1040)
I
M
RPVA
TTL
L
----
M
V
A
I
L
L
A
G
IIG
Y
RA
LPV
S
AL
P
E
V
DY
P
T
I
Q
V
V
T
L
YPGA
S
PD
V
M
T
S
A
VT
A
PL
E
RQ
F
GQ
M
S
GL
K
Q
MSS
Q
S
SG-
G
ASV
ITL
Q
F
Q
L
TL
P
L
D
V
A
EQ
E
VQ
AA
IN
A
A
TNL
LP
SDLPNP
P
V
YSKVNPADP
---
P
I
MTL
A
VT
S
T--AMPMT
Q
V
E
D
M
V
ETR
V
AQK
I
S
QIS
GVG
L
V
TLS
G
GQRPAV
R
V
K
L
NA
QA
IA
ALG
L
TSET
V
RT
AI
TGA
N
VNSAK
G
S
L
--
-
-
--DGPSRAVT
L
S
A
NDQ
M
Q
S
A
EE
Y
RQ
L
I
I
AYQ-
N
G
AP
I
R
L
G
DVA
T
VE
Q
G
A
E
NSWLG
A
WA
N
K
E
-
Q
A
I
V
MN
V
Q
R
QP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TES
L
P
K
S
VK
VTVL
S
D
R
T
TN
I
RA
S
V
D
D
TQFE
L
M
M
AI
A
LV
V
M
I
I
YLFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
A
V
M
V
F
L
D
F
S
I
N
N
LT
L
M
A
L
T
I
A
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
K
GEK
P
LA
A
AL
K
GAG
E
I
G
F
TI
ISLTFS
L
I
AV
L
IP
L
L
F
MG
D
IV
G
R
LF
R
E
F
A
IT
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRAS
E
KM
F
DRIIAA
----
Y
GRGLA
KVL
NHPWLT
L
S
V
A
L
S
TLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VA
D
--
VILQDPA
V
Q
S
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQ
V
SR
T
QYQFT
L
QAT---SL
D
A
L
STWVP
QL
MEK
L
QQL
P
-Q
I
SD
V
SS
D
W
QD
KGLVAY
VNVD
RD
S
A
S
R
L
G
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
L
E
HNTEN
T
PG
L
AA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SF
N
V
PDNY
S
L
G
D
A
VQAIMDTEKT
L
N
L
P
V
D
ITTQ
F
Q
G
ST
LA
F
Q
SA
L
GS--TVW
L
I
V
-
A
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAE
R
EQ
----------
G
MSPR
D
A
IYQ
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
IV
S
Q
V
L
T
L
F
TT
P
VI
Y
L
L
fig|570506.3.peg.3472
Escherichia coli O157:H7 str. FRIK966 (17-1021/1040)
I
M
RPVA
TTL
L
----
M
V
A
I
L
L
A
G
IIG
Y
RA
LPV
S
AL
P
E
V
DY
P
T
I
Q
V
V
T
L
YPGA
S
PD
V
M
T
S
A
VT
A
PL
E
RQ
F
GQ
M
S
GL
K
Q
MSS
Q
S
SG-
G
ASV
ITL
Q
F
Q
L
TL
P
L
D
V
A
EQ
E
VQ
AA
IN
A
A
TNL
LP
SDLPNP
P
V
YSKVNPADP
---
P
I
MTL
A
VT
S
T--AMPMT
Q
V
E
D
M
V
ETR
V
AQK
I
S
QIS
GVG
L
V
TLS
G
GQRPAV
R
V
K
L
NA
QA
IA
ALG
L
TSET
V
RT
AI
TGA
N
VNSAK
G
S
L
--
-
-
--DGPSRAVT
L
S
A
NDQ
M
Q
S
A
EE
Y
RQ
L
I
I
AYQ-
N
G
AP
I
R
L
G
DVA
T
VE
Q
G
A
E
NSWLG
A
WA
N
K
E
-
Q
A
I
V
MN
V
Q
R
QP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TES
L
P
K
S
VK
VTVL
S
D
R
T
TN
I
RA
S
V
D
D
TQFE
L
M
M
AI
A
LV
V
M
I
I
YLFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
A
V
M
V
F
L
D
F
S
I
N
N
LT
L
M
A
L
T
I
A
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
K
GEK
P
LA
A
AL
K
GAG
E
I
G
F
TI
ISLTFS
L
I
AV
L
IP
L
L
F
MG
D
IV
G
R
LF
R
E
F
A
IT
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRAS
E
KM
F
DRIIAA
----
Y
GRGLA
KVL
NHPWLT
L
S
V
A
L
S
TLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VA
D
--
VILQDPA
V
Q
S
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQ
V
SR
T
QYQFT
L
QAT---SL
D
A
L
STWVP
QL
MEK
L
QQL
P
-Q
I
SD
V
SS
D
W
QD
KGLVAY
VNVD
RD
S
A
S
R
L
G
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
L
E
HNTEN
T
PG
L
AA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SF
N
V
PDNY
S
L
G
D
A
VQAIMDTEKT
L
N
L
P
V
D
ITTQ
F
Q
G
ST
LA
F
Q
SA
L
GS--TVW
L
I
V
-
A
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAE
R
EQ
----------
G
MSPR
D
A
IYQ
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
IV
S
Q
V
L
T
L
F
TT
P
VI
Y
L
L
fig|386585.9.peg.3015
Escherichia coli O157:H7 str. Sakai (17-1021/1040)
I
M
RPVA
TTL
L
----
M
V
A
I
L
L
A
G
IIG
Y
RA
LPV
S
AL
P
E
V
DY
P
T
I
Q
V
V
T
L
YPGA
S
PD
V
M
T
S
A
VT
A
PL
E
RQ
F
GQ
M
S
GL
K
Q
MSS
Q
S
SG-
G
ASV
ITL
Q
F
Q
L
TL
P
L
D
V
A
EQ
E
VQ
AA
IN
A
A
TNL
LP
SDLPNP
P
V
YSKVNPADP
---
P
I
MTL
A
VT
S
T--AMPMT
Q
V
E
D
M
V
ETR
V
AQK
I
S
QIS
GVG
L
V
TLS
G
GQRPAV
R
V
K
L
NA
QA
IA
ALG
L
TSET
V
RT
AI
TGA
N
VNSAK
G
S
L
--
-
-
--DGPSRAVT
L
S
A
NDQ
M
Q
S
A
EE
Y
RQ
L
I
I
AYQ-
N
G
AP
I
R
L
G
DVA
T
VE
Q
G
A
E
NSWLG
A
WA
N
K
E
-
Q
A
I
V
MN
V
Q
R
QP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TES
L
P
K
S
VK
VTVL
S
D
R
T
TN
I
RA
S
V
D
D
TQFE
L
M
M
AI
A
LV
V
M
I
I
YLFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
A
V
M
V
F
L
D
F
S
I
N
N
LT
L
M
A
L
T
I
A
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
K
GEK
P
LA
A
AL
K
GAG
E
I
G
F
TI
ISLTFS
L
I
AV
L
IP
L
L
F
MG
D
IV
G
R
LF
R
E
F
A
IT
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRAS
E
KM
F
DRIIAA
----
Y
GRGLA
KVL
NHPWLT
L
S
V
A
L
S
TLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VA
D
--
VILQDPA
V
Q
S
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQ
V
SR
T
QYQFT
L
QAT---SL
D
A
L
STWVP
QL
MEK
L
QQL
P
-Q
I
SD
V
SS
D
W
QD
KGLVAY
VNVD
RD
S
A
S
R
L
G
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
L
E
HNTEN
T
PG
L
AA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SF
N
V
PDNY
S
L
G
D
A
VQAIMDTEKT
L
N
L
P
V
D
ITTQ
F
Q
G
ST
LA
F
Q
SA
L
GS--TVW
L
I
V
-
A
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAE
R
EQ
----------
G
MSPR
D
A
IYQ
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
IV
S
Q
V
L
T
L
F
TT
P
VI
Y
L
L
fig|502346.5.peg.4502
Escherichia coli O157:H7 str. TW14588 (17-1021/1040)
I
M
RPVA
TTL
L
----
M
V
A
I
L
L
A
G
IIG
Y
RA
LPV
S
AL
P
E
V
DY
P
T
I
Q
V
V
T
L
YPGA
S
PD
V
M
T
S
A
VT
A
PL
E
RQ
F
GQ
M
S
GL
K
Q
MSS
Q
S
SG-
G
ASV
ITL
Q
F
Q
L
TL
P
L
D
V
A
EQ
E
VQ
AA
IN
A
A
TNL
LP
SDLPNP
P
V
YSKVNPADP
---
P
I
MTL
A
VT
S
T--AMPMT
Q
V
E
D
M
V
ETR
V
AQK
I
S
QIS
GVG
L
V
TLS
G
GQRPAV
R
V
K
L
NA
QA
IA
ALG
L
TSET
V
RT
AI
TGA
N
VNSAK
G
S
L
--
-
-
--DGPSRAVT
L
S
A
NDQ
M
Q
S
A
EE
Y
RQ
L
I
I
AYQ-
N
G
AP
I
R
L
G
DVA
T
VE
Q
G
A
E
NSWLG
A
WA
N
K
E
-
Q
A
I
V
MN
V
Q
R
QP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TES
L
P
K
S
VK
VTVL
S
D
R
T
TN
I
RA
S
V
D
D
TQFE
L
M
M
AI
A
LV
V
M
I
I
YLFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
A
V
M
V
F
L
D
F
S
I
N
N
LT
L
M
A
L
T
I
A
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
K
GEK
P
LA
A
AL
K
GAG
E
I
G
F
TI
ISLTFS
L
I
AV
L
IP
L
L
F
MG
D
IV
G
R
LF
R
E
F
A
IT
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRAS
E
KM
F
DRIIAA
----
Y
GRGLA
KVL
NHPWLT
L
S
V
A
L
S
TLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VA
D
--
VILQDPA
V
Q
S
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQ
V
SR
T
QYQFT
L
QAT---SL
D
A
L
STWVP
QL
MEK
L
QQL
P
-Q
I
SD
V
SS
D
W
QD
KGLVAY
VNVD
RD
S
A
S
R
L
G
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
L
E
HNTEN
T
PG
L
AA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SF
N
V
PDNY
S
L
G
D
A
VQAIMDTEKT
L
N
L
P
V
D
ITTQ
F
Q
G
ST
LA
F
Q
SA
L
GS--TVW
L
I
V
-
A
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAE
R
EQ
----------
G
MSPR
D
A
IYQ
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
IV
S
Q
V
L
T
L
F
TT
P
VI
Y
L
L
fig|340186.3.peg.2458
Escherichia coli E110019 (17-1021/1040)
I
M
RPVA
TTL
L
----
M
V
A
I
L
L
A
G
IIG
Y
RA
LPV
S
AL
P
E
V
DY
P
T
I
Q
V
V
T
L
YPGA
S
PD
V
M
T
S
A
VT
A
PL
E
RQ
F
GQ
M
S
GL
K
Q
MSS
Q
S
SG-
G
ASV
ITL
Q
F
Q
L
TL
P
L
D
V
A
EQ
E
VQ
AA
IN
A
A
TNL
LP
SDLPNP
P
V
YSKVNPADP
---
P
I
MTL
A
VT
S
T--AMPMT
Q
V
E
D
M
V
ETR
V
AQK
I
S
QIS
GVG
L
V
TLS
G
GQRPAV
R
V
K
L
NA
QA
IA
ALG
L
TSET
V
RT
AI
TGA
N
VNSAK
G
S
L
--
-
-
--DGPSRAVT
L
S
A
NDQ
M
Q
S
A
EE
Y
RQ
L
I
I
AYQ-
N
G
AP
I
R
L
G
DVA
T
VE
Q
G
A
E
NSWLG
A
WA
N
K
E
-
Q
A
I
V
MN
V
Q
R
QP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TES
L
P
K
S
VK
VTVL
S
D
R
T
TN
I
RA
S
V
D
D
TQFE
L
M
M
AI
A
LV
V
M
I
N
YLFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
A
V
M
V
F
L
D
F
S
I
N
N
LT
L
M
A
L
T
I
A
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
K
GEK
P
LA
A
AL
K
GAG
E
I
G
F
TI
ISLTFS
L
I
AV
L
IP
L
L
F
MG
D
IV
G
R
LF
R
E
F
A
IT
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRAS
E
KM
F
DRIIAA
----
Y
GRGLA
KVL
NHPWLT
L
S
V
A
L
S
TLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VA
D
--
VILQDPA
V
Q
S
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQ
V
SR
T
QYQFT
L
QAT---SL
D
A
L
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
QD
KGLVAY
VNVD
RD
S
A
S
R
L
G
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
L
E
HNTEN
T
PG
L
AA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SF
N
V
PDNY
S
L
G
D
A
VQAIMDTEKT
L
N
L
P
V
D
ITTQ
F
Q
G
ST
LA
F
Q
SA
L
GS--TVW
L
I
V
-
A
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAE
R
EQ
----------
G
MSPR
EA
IYQ
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
IV
S
Q
V
L
T
L
F
TT
P
VI
Y
L
L
fig|340186.5.peg.2537
Escherichia coli E110019 (17-1021/1040)
I
M
RPVA
TTL
L
----
M
V
A
I
L
L
A
G
IIG
Y
RA
LPV
S
AL
P
E
V
DY
P
T
I
Q
V
V
T
L
YPGA
S
PD
V
M
T
S
A
VT
A
PL
E
RQ
F
GQ
M
S
GL
K
Q
MSS
Q
S
SG-
G
ASV
ITL
Q
F
Q
L
TL
P
L
D
V
A
EQ
E
VQ
AA
IN
A
A
TNL
LP
SDLPNP
P
V
YSKVNPADP
---
P
I
MTL
A
VT
S
T--AMPMT
Q
V
E
D
M
V
ETR
V
AQK
I
S
QIS
GVG
L
V
TLS
G
GQRPAV
R
V
K
L
NA
QA
IA
ALG
L
TSET
V
RT
AI
TGA
N
VNSAK
G
S
L
--
-
-
--DGPSRAVT
L
S
A
NDQ
M
Q
S
A
EE
Y
RQ
L
I
I
AYQ-
N
G
AP
I
R
L
G
DVA
T
VE
Q
G
A
E
NSWLG
A
WA
N
K
E
-
Q
A
I
V
MN
V
Q
R
QP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TES
L
P
K
S
VK
VTVL
S
D
R
T
TN
I
RA
S
V
D
D
TQFE
L
M
M
AI
A
LV
V
M
I
N
YLFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
A
V
M
V
F
L
D
F
S
I
N
N
LT
L
M
A
L
T
I
A
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
K
GEK
P
LA
A
AL
K
GAG
E
I
G
F
TI
ISLTFS
L
I
AV
L
IP
L
L
F
MG
D
IV
G
R
LF
R
E
F
A
IT
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRAS
E
KM
F
DRIIAA
----
Y
GRGLA
KVL
NHPWLT
L
S
V
A
L
S
TLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VA
D
--
VILQDPA
V
Q
S
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQ
V
SR
T
QYQFT
L
QAT---SL
D
A
L
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
QD
KGLVAY
VNVD
RD
S
A
S
R
L
G
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
L
E
HNTEN
T
PG
L
AA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SF
N
V
PDNY
S
L
G
D
A
VQAIMDTEKT
L
N
L
P
V
D
ITTQ
F
Q
G
ST
LA
F
Q
SA
L
GS--TVW
L
I
V
-
A
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAE
R
EQ
----------
G
MSPR
EA
IYQ
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
IV
S
Q
V
L
T
L
F
TT
P
VI
Y
L
L
fig|656444.3.peg.3048
Escherichia coli TA280 (17-1021/1040)
I
M
RPVA
TTL
L
----
M
V
A
I
L
L
A
G
IIS
Y
RA
LPV
S
AL
P
E
V
DY
P
T
I
Q
V
V
T
L
YPGA
S
PD
V
M
T
S
A
VT
A
PL
E
RQ
F
GQ
M
S
GL
K
Q
MSS
Q
S
SG-
G
ASV
ITL
Q
F
Q
L
TL
P
L
D
V
A
EQ
E
VQ
AA
IN
A
A
TNL
LP
SDLPNP
P
V
YSKVNPADP
---
P
I
MTL
A
VT
S
T--AMPMT
Q
V
E
D
M
V
ETR
V
AQK
I
S
QIS
GVG
L
V
TLS
G
GQRPAV
R
V
K
L
NA
QA
IA
ALG
L
TSET
V
RT
AI
TGA
N
VNSAK
G
S
L
--
-
-
--DGPSRAVT
L
S
A
NDQ
M
Q
S
A
EE
Y
RQ
L
I
I
AYQ-
N
G
AP
I
R
L
G
DVA
T
VE
Q
G
A
E
NSWLG
A
WA
N
K
E
-
Q
A
I
V
MN
V
Q
R
QP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TES
L
P
K
S
VK
VTVL
S
D
R
T
TN
I
RA
S
V
D
D
TQFE
L
M
M
AI
A
LV
V
M
I
I
YLFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
A
V
M
V
F
L
D
F
S
I
N
N
LT
L
M
A
L
T
I
A
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
K
GEK
P
LA
A
AL
K
GAG
E
I
G
F
TI
ISLTFS
L
I
AV
L
IP
L
L
F
MG
D
IV
G
R
LF
R
E
F
A
IT
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRAS
E
KM
F
DRIIAA
----
Y
GRGLA
KVL
NHPWLT
L
S
V
A
L
S
TLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VA
D
--
VILQDPA
V
Q
S
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQ
V
SR
T
QYQFT
L
QAT---SL
D
A
L
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
QD
KGLVAY
VNVD
RD
S
A
S
R
L
G
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
L
E
HNTEN
T
PG
L
AA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SF
N
V
PDNY
S
L
G
D
A
VQAIMDTEKT
L
N
L
P
V
D
ITTQ
F
Q
G
ST
LA
F
Q
SA
L
GS--TVW
L
I
V
-
A
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAE
R
EQ
----------
G
MSPR
D
A
IYQ
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
IV
S
Q
V
L
T
L
F
TT
P
VI
Y
L
L
fig|216593.1.peg.2687
Escherichia coli E2348/69 (17-1021/1040)
I
M
RPVA
TTL
L
----
M
V
A
I
L
L
A
G
IIG
Y
QA
LPV
S
AL
P
E
V
DY
P
T
I
Q
V
V
T
L
YPGA
S
PD
V
M
T
S
A
VT
A
PL
E
RQ
F
GQ
M
S
GL
K
Q
MSS
Q
S
SG-
G
ASV
ITL
Q
F
Q
L
TL
P
L
D
V
A
EQ
E
VQ
AA
IN
A
A
TNL
LP
SDLPNP
P
V
YSKVNPADP
---
P
I
MTL
A
VT
S
T--AMPMT
Q
V
E
D
M
V
ETR
V
AQK
I
S
QIS
GVG
L
V
TLS
G
GQRPAV
R
V
K
L
NA
QA
IA
ALG
L
TSET
V
RT
AI
TGA
N
VNSAK
G
S
L
--
-
-
--DGPSRAVT
L
S
A
NDQ
M
Q
S
A
EE
Y
RQ
L
I
I
AYQ-
N
G
AP
I
R
L
G
DVA
T
VE
Q
G
A
E
NSWLG
A
WA
N
K
E
-
Q
A
I
V
MN
V
Q
R
QP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TES
L
P
K
S
VK
VTVL
S
D
R
T
TN
I
RA
S
V
D
D
TQFE
L
M
M
AI
A
LV
V
M
I
I
YLFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
A
V
M
V
F
L
D
F
S
I
N
N
LT
L
M
A
L
T
I
A
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
K
GEK
P
LA
A
AL
K
GAG
E
I
G
F
TI
ISLTFS
L
I
AV
L
IP
L
L
F
MG
D
IV
G
R
LF
R
E
F
A
IT
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRAS
E
KM
F
ERIIAA
----
Y
GQGLA
KVL
NHPWLT
L
S
V
A
L
S
TLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VA
D
--
VILQDPA
V
Q
S
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQ
V
SR
T
QYQFT
L
QAT---SL
D
A
L
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
QD
KGLVAY
VNVD
RD
S
A
S
R
L
G
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
L
E
HNTEN
T
PG
L
AA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SF
N
V
PDNY
S
L
G
D
A
VQAIMDTEKT
L
N
L
P
V
D
ITTQ
F
Q
G
ST
LA
F
Q
SA
L
GS--TVW
L
I
V
-
A
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAE
R
EQ
----------
G
MSPR
D
A
IYQ
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
IV
S
Q
V
L
T
L
F
TT
P
VI
Y
L
L
fig|574521.7.peg.2266
Escherichia coli O127:H6 str. E2348/69 (17-1021/1040)
I
M
RPVA
TTL
L
----
M
V
A
I
L
L
A
G
IIG
Y
QA
LPV
S
AL
P
E
V
DY
P
T
I
Q
V
V
T
L
YPGA
S
PD
V
M
T
S
A
VT
A
PL
E
RQ
F
GQ
M
S
GL
K
Q
MSS
Q
S
SG-
G
ASV
ITL
Q
F
Q
L
TL
P
L
D
V
A
EQ
E
VQ
AA
IN
A
A
TNL
LP
SDLPNP
P
V
YSKVNPADP
---
P
I
MTL
A
VT
S
T--AMPMT
Q
V
E
D
M
V
ETR
V
AQK
I
S
QIS
GVG
L
V
TLS
G
GQRPAV
R
V
K
L
NA
QA
IA
ALG
L
TSET
V
RT
AI
TGA
N
VNSAK
G
S
L
--
-
-
--DGPSRAVT
L
S
A
NDQ
M
Q
S
A
EE
Y
RQ
L
I
I
AYQ-
N
G
AP
I
R
L
G
DVA
T
VE
Q
G
A
E
NSWLG
A
WA
N
K
E
-
Q
A
I
V
MN
V
Q
R
QP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TES
L
P
K
S
VK
VTVL
S
D
R
T
TN
I
RA
S
V
D
D
TQFE
L
M
M
AI
A
LV
V
M
I
I
YLFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
A
V
M
V
F
L
D
F
S
I
N
N
LT
L
M
A
L
T
I
A
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
K
GEK
P
LA
A
AL
K
GAG
E
I
G
F
TI
ISLTFS
L
I
AV
L
IP
L
L
F
MG
D
IV
G
R
LF
R
E
F
A
IT
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRAS
E
KM
F
ERIIAA
----
Y
GQGLA
KVL
NHPWLT
L
S
V
A
L
S
TLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VA
D
--
VILQDPA
V
Q
S
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQ
V
SR
T
QYQFT
L
QAT---SL
D
A
L
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
QD
KGLVAY
VNVD
RD
S
A
S
R
L
G
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
L
E
HNTEN
T
PG
L
AA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SF
N
V
PDNY
S
L
G
D
A
VQAIMDTEKT
L
N
L
P
V
D
ITTQ
F
Q
G
ST
LA
F
Q
SA
L
GS--TVW
L
I
V
-
A
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAE
R
EQ
----------
G
MSPR
D
A
IYQ
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
IV
S
Q
V
L
T
L
F
TT
P
VI
Y
L
L
fig|344601.3.peg.3240
Escherichia coli B171 (17-1021/1040)
I
M
RPVA
TTL
L
----
M
V
A
I
L
L
A
G
IIG
Y
RA
LPV
S
AL
P
E
V
DY
P
T
I
Q
V
V
T
L
YPGA
S
PD
V
M
T
S
A
VT
A
PL
E
RQ
F
GQ
M
S
GL
K
Q
MSS
Q
S
SG-
G
ASV
ITL
Q
F
Q
L
TL
P
L
D
V
A
EQ
E
VQ
AA
IN
A
A
TNL
LP
SDLPNP
P
V
YSKVNPADP
---
P
I
MTL
A
VT
S
T--AMPMT
Q
V
E
D
M
V
ETR
V
AQK
I
S
QIS
GVG
L
V
TLS
G
GQRPAV
R
V
K
L
NA
QA
IA
ALG
L
TSET
V
RT
AI
TGA
N
VNSAK
G
S
L
--
-
-
--DGPSRAVT
L
S
A
NDQ
M
Q
S
A
EE
Y
RQ
L
I
I
AYQ-
N
G
AP
I
R
L
G
DVA
T
VE
Q
G
A
E
NSWLG
A
WA
N
K
E
-
Q
A
I
V
MN
V
Q
R
QP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TES
L
P
K
S
VK
VTVL
S
D
R
T
TN
I
RA
S
V
D
D
TQFE
L
M
M
AI
A
LV
V
M
I
I
YLFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
A
V
M
V
F
L
D
F
S
I
N
N
LT
L
M
A
L
T
I
A
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
K
GEK
P
LA
A
AL
K
GAG
E
I
G
F
TI
ISLTFS
L
I
AV
L
IP
L
L
F
MG
D
IV
G
R
LF
R
E
F
A
IT
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRAS
E
KM
F
DRIIAA
----
Y
GRGLA
KVL
NHPWLT
L
S
V
A
L
S
TLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VA
D
--
VILQDPA
V
Q
S
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQ
V
SR
T
QYQFT
L
QAT---SL
D
A
L
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
QD
KGLVAY
VNVD
RD
S
A
S
R
L
G
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
L
E
HNTEI
T
PG
L
AA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KVEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SF
N
V
PDNY
S
L
G
D
A
VQAIMDTEKT
L
N
L
P
V
D
ITTQ
F
Q
G
S
P
LA
F
Q
SA
L
GS--TVW
L
I
V
-
A
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAE
R
EQ
----------
G
MSPR
EA
IYQ
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
IV
S
Q
V
L
T
L
F
TT
P
VI
Y
L
L
fig|344601.5.peg.3386
Escherichia coli B171 (17-1021/1040)
I
M
RPVA
TTL
L
----
M
V
A
I
L
L
A
G
IIG
Y
RA
LPV
S
AL
P
E
V
DY
P
T
I
Q
V
V
T
L
YPGA
S
PD
V
M
T
S
A
VT
A
PL
E
RQ
F
GQ
M
S
GL
K
Q
MSS
Q
S
SG-
G
ASV
ITL
Q
F
Q
L
TL
P
L
D
V
A
EQ
E
VQ
AA
IN
A
A
TNL
LP
SDLPNP
P
V
YSKVNPADP
---
P
I
MTL
A
VT
S
T--AMPMT
Q
V
E
D
M
V
ETR
V
AQK
I
S
QIS
GVG
L
V
TLS
G
GQRPAV
R
V
K
L
NA
QA
IA
ALG
L
TSET
V
RT
AI
TGA
N
VNSAK
G
S
L
--
-
-
--DGPSRAVT
L
S
A
NDQ
M
Q
S
A
EE
Y
RQ
L
I
I
AYQ-
N
G
AP
I
R
L
G
DVA
T
VE
Q
G
A
E
NSWLG
A
WA
N
K
E
-
Q
A
I
V
MN
V
Q
R
QP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TES
L
P
K
S
VK
VTVL
S
D
R
T
TN
I
RA
S
V
D
D
TQFE
L
M
M
AI
A
LV
V
M
I
I
YLFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
A
V
M
V
F
L
D
F
S
I
N
N
LT
L
M
A
L
T
I
A
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
K
GEK
P
LA
A
AL
K
GAG
E
I
G
F
TI
ISLTFS
L
I
AV
L
IP
L
L
F
MG
D
IV
G
R
LF
R
E
F
A
IT
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRAS
E
KM
F
DRIIAA
----
Y
GRGLA
KVL
NHPWLT
L
S
V
A
L
S
TLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VA
D
--
VILQDPA
V
Q
S
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQ
V
SR
T
QYQFT
L
QAT---SL
D
A
L
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
QD
KGLVAY
VNVD
RD
S
A
S
R
L
G
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
L
E
HNTEI
T
PG
L
AA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KVEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SF
N
V
PDNY
S
L
G
D
A
VQAIMDTEKT
L
N
L
P
V
D
ITTQ
F
Q
G
S
P
LA
F
Q
SA
L
GS--TVW
L
I
V
-
A
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAE
R
EQ
----------
G
MSPR
EA
IYQ
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
IV
S
Q
V
L
T
L
F
TT
P
VI
Y
L
L
fig|216592.1.peg.2869
Escherichia coli 042 (17-1021/1040)
I
M
RPVA
TTL
L
----
M
V
A
I
L
L
A
G
IIG
Y
RA
LPV
S
AL
P
E
V
DY
P
T
I
Q
V
V
T
L
YPGA
S
PD
V
M
T
S
A
VT
A
PL
E
RQ
F
GQ
M
S
GL
K
Q
MSS
Q
S
SG-
G
ASV
ITL
Q
F
Q
L
TL
P
L
D
V
A
EQ
E
VQ
AA
IN
A
A
TNL
LP
SDLPNP
P
V
YSKVNPADP
---
P
I
MTL
A
VT
S
T--AMPMT
Q
V
E
D
M
V
ETR
V
AQK
I
S
QIS
GVG
L
V
TLS
G
GQRPAV
R
V
K
L
NA
QA
IA
ALG
L
TSET
V
RT
AI
TGA
N
VNSAK
G
S
L
--
-
-
--DGPSRAVT
L
S
A
NDQ
M
Q
S
A
EE
Y
RQ
L
I
I
AYQ-
N
G
AP
I
R
L
G
DVA
T
VE
Q
G
A
E
NSWLG
A
WA
N
K
E
-
Q
A
I
V
MN
V
Q
R
QP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TES
L
P
K
S
VK
VTVL
S
D
R
T
TN
I
RA
S
V
D
D
TQFE
L
M
M
AI
A
LV
V
M
I
I
YLFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
A
V
M
V
F
L
D
F
S
I
N
N
LT
L
M
A
L
T
I
A
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
K
GEK
P
LA
A
AL
K
GAG
E
I
G
F
TI
ISLTFS
L
I
AV
L
IP
L
L
F
MG
D
IV
G
R
LF
R
E
F
A
IT
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRAS
E
KM
F
DRIIAA
----
Y
GRGLA
KVL
NHPWLT
L
S
V
A
L
S
TLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VA
D
--
VILQDPA
V
Q
S
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQ
V
SR
T
QYQFT
L
QAT---TL
D
A
L
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
QD
QGLVAY
VNVD
RD
S
A
S
R
L
G
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
L
E
HNTEN
T
PG
L
AA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SF
N
V
PDNY
S
L
G
D
A
VQAIMDTEKT
L
N
L
P
V
D
ITTQ
F
Q
G
ST
LA
F
Q
SA
L
GS--TVW
L
I
V
-
A
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAE
R
EQ
----------
G
MSPR
D
A
IYQ
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
IV
S
Q
V
L
T
L
F
TT
P
VI
Y
L
L
fig|216592.3.peg.2415
Escherichia coli 042 (17-1021/1040)
I
M
RPVA
TTL
L
----
M
V
A
I
L
L
A
G
IIG
Y
RA
LPV
S
AL
P
E
V
DY
P
T
I
Q
V
V
T
L
YPGA
S
PD
V
M
T
S
A
VT
A
PL
E
RQ
F
GQ
M
S
GL
K
Q
MSS
Q
S
SG-
G
ASV
ITL
Q
F
Q
L
TL
P
L
D
V
A
EQ
E
VQ
AA
IN
A
A
TNL
LP
SDLPNP
P
V
YSKVNPADP
---
P
I
MTL
A
VT
S
T--AMPMT
Q
V
E
D
M
V
ETR
V
AQK
I
S
QIS
GVG
L
V
TLS
G
GQRPAV
R
V
K
L
NA
QA
IA
ALG
L
TSET
V
RT
AI
TGA
N
VNSAK
G
S
L
--
-
-
--DGPSRAVT
L
S
A
NDQ
M
Q
S
A
EE
Y
RQ
L
I
I
AYQ-
N
G
AP
I
R
L
G
DVA
T
VE
Q
G
A
E
NSWLG
A
WA
N
K
E
-
Q
A
I
V
MN
V
Q
R
QP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TES
L
P
K
S
VK
VTVL
S
D
R
T
TN
I
RA
S
V
D
D
TQFE
L
M
M
AI
A
LV
V
M
I
I
YLFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
A
V
M
V
F
L
D
F
S
I
N
N
LT
L
M
A
L
T
I
A
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
K
GEK
P
LA
A
AL
K
GAG
E
I
G
F
TI
ISLTFS
L
I
AV
L
IP
L
L
F
MG
D
IV
G
R
LF
R
E
F
A
IT
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRAS
E
KM
F
DRIIAA
----
Y
GRGLA
KVL
NHPWLT
L
S
V
A
L
S
TLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VA
D
--
VILQDPA
V
Q
S
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQ
V
SR
T
QYQFT
L
QAT---TL
D
A
L
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
QD
QGLVAY
VNVD
RD
S
A
S
R
L
G
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
L
E
HNTEN
T
PG
L
AA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SF
N
V
PDNY
S
L
G
D
A
VQAIMDTEKT
L
N
L
P
V
D
ITTQ
F
Q
G
ST
LA
F
Q
SA
L
GS--TVW
L
I
V
-
A
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAE
R
EQ
----------
G
MSPR
D
A
IYQ
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
IV
S
Q
V
L
T
L
F
TT
P
VI
Y
L
L
fig|550677.3.peg.4076
Escherichia coli B354 (16-1018/1037)
AI
I
M
M
L
A
G
GLA
I
MN
LPV
A
QYP
Q
I
AP
P
T
I
T
I
S
A
T
YPGA
D
AQ
T
V
E
D
S
VT
Q
VIE
QN
M
NG
L
D
GLM
Y
MSS
T
S
DAA
G
NAS
ITL
T
FE
T
GT
S
PD
I
A
QV
QVQ
NK
LQ
L
A
MPS
LP
EAVQQQ
G
I
SVD-KSSSN
---
I
L
MVA
A
FI
S
DNGSLNQY
DI
A
D
Y
V
ASN
I
KDP
LS
RTA
GVG
S
V
QLF
G
SEY-AM
RI
W
LDP
QK
LN
KYN
L
VPSD
V
IS
Q
I
KVQ
N
NQISG
GQLGG
M
P
QAADQQLNAS
I
I
V
QTR
LQT
P
EEF
GK
I
L
L
KVQQ
DG
SQ
V
L
L
R
DVA
R
VE
L
G
A
E
DYSTV
A
RY
NGK
-
P
A
A
G
IA
I
K
L
AT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAY
FP
A
S
L
K
TVYP
YDTT
PF
I
EI
SI
Q
E
VFKT
L
V
EAI
I
LV
F
LV
M
YLFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
A
I
L
S
A
V
G
F
T
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
D
KLP
P
KE
A
TH
K
SMG
QIQ
R
AL
VGIAVV
L
S
AVF
M
PM
A
F
MS
G
AT
G
E
IYR
Q
FSIT
LIS
S
M
LL
SV
F
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARF
N
TL
F
EKSTQH
----
Y
TNSTR
S
L
L
RCTGRY
M
V
VY
L
L
ICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
L
P
S
G
A
T
MVNTTKVLQ
Q
VT
DYY
LTKEKDN
V
Q
SVF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVT
AII
Q
RA
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AEL
G
TA
S
GFDME
L
LDNGNLGH
E
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
TG
V
RP
N
G
LE
DTPMFK
VNV
N
AA
KA
E
A
M
GV
A
L
S
DI
NQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
ML
P
DN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
GS
PR
L
ERY
N
GI
P
SME
I
LG
EA
AAGK
S
T
G
D
A
MKFMADLVAK
L
-
-
P
A
G
VGYS
W
T
G
--
LS
YQ
EA
L
SSNQAPA
L
Y
A
-
I
S
L
V
V
VFL
A
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LS
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
VEMM
Q
KE
----------
G
KTPI
EA
IIE
A
ARM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
VI
S
H
GAGSG
AQNA
VG
T
GVMGGM
FA
A
T
V
LAI
Y
fig|656379.3.peg.4834
Escherichia coli FVEC1302 (16-1018/1037)
AI
I
M
M
L
A
G
GLA
I
MN
LPV
A
QYP
Q
I
AP
P
T
I
T
I
S
A
T
YPGA
D
AQ
T
V
E
D
S
VT
Q
VIE
QN
M
NG
L
D
GLM
Y
MSS
T
S
DAA
G
NAS
ITL
T
FE
T
GT
S
PD
I
A
QV
QVQ
NK
LQ
L
A
MPS
LP
EAVQQQ
G
I
SVD-KSSSN
---
I
L
MVA
A
FI
S
DNGSLNQY
DI
A
D
Y
V
ASN
I
KDP
LS
RTA
GVG
S
V
QLF
G
SEY-AM
RI
W
LDP
QK
LN
KYN
L
VPSD
V
IS
Q
I
KVQ
N
NQISG
GQLGG
M
P
QAADQQLNAS
I
I
V
QTR
LQT
P
EEF
GK
I
L
L
KVQQ
DG
SQ
V
L
L
R
DVA
R
VE
L
G
A
E
DYSTV
A
RY
NGK
-
P
A
A
G
IA
I
K
L
AT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAY
FP
A
S
L
K
TVYP
YDTT
PF
I
EI
SI
Q
E
VFKT
L
V
EAI
I
LV
F
LV
M
YLFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
A
I
L
S
A
V
G
F
T
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
D
KLP
P
KE
A
TH
K
SMG
QIQ
R
AL
VGIAVV
L
S
AVF
M
PM
A
F
MS
G
AT
G
E
IYR
Q
FSIT
LIS
S
M
LL
SV
F
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARF
N
TL
F
EKSTQH
----
Y
TNSTR
S
L
L
RCTGRY
M
V
VY
L
L
ICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
L
P
S
G
A
T
MVNTTKVLQ
Q
VT
DYY
LTKEKDN
V
Q
SVF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVT
AII
Q
RA
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AEL
G
TA
S
GFDME
L
LDNGNLGH
E
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
TG
V
RP
N
G
LE
DTPMFK
VNV
N
AA
KA
E
A
M
GV
A
L
S
DI
NQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
ML
P
DN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
GS
PR
L
ERY
N
GI
P
SME
I
LG
EA
AAGK
S
T
G
D
A
MKFMADLVAK
L
-
-
P
A
G
VGYS
W
T
G
--
LS
YQ
EA
L
SSNQAPA
L
Y
A
-
I
S
L
V
V
VFL
A
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LS
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
VEMM
Q
KE
----------
G
KTPI
EA
IIE
A
ARM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
VI
S
H
GAGSG
AQNA
VG
T
GVMGGM
FA
A
T
V
LAI
Y
fig|656380.3.peg.4621
Escherichia coli FVEC1412 (16-1018/1037)
AI
I
M
M
L
A
G
GLA
I
MN
LPV
A
QYP
Q
I
AP
P
T
I
T
I
S
A
T
YPGA
D
AQ
T
V
E
D
S
VT
Q
VIE
QN
M
NG
L
D
GLM
Y
MSS
T
S
DAA
G
NAS
ITL
T
FE
T
GT
S
PD
I
A
QV
QVQ
NK
LQ
L
A
MPS
LP
EAVQQQ
G
I
SVD-KSSSN
---
I
L
MVA
A
FI
S
DNGSLNQY
DI
A
D
Y
V
ASN
I
KDP
LS
RTA
GVG
S
V
QLF
G
SEY-AM
RI
W
LDP
QK
LN
KYN
L
VPSD
V
IS
Q
I
KVQ
N
NQISG
GQLGG
M
P
QAADQQLNAS
I
I
V
QTR
LQT
P
EEF
GK
I
L
L
KVQQ
DG
SQ
V
L
L
R
DVA
R
VE
L
G
A
E
DYSTV
A
RY
NGK
-
P
A
A
G
IA
I
K
L
AT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAY
FP
A
S
L
K
TVYP
YDTT
PF
I
EI
SI
Q
E
VFKT
L
V
EAI
I
LV
F
LV
M
YLFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
A
I
L
S
A
V
G
F
T
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
D
KLP
P
KE
A
TH
K
SMG
QIQ
R
AL
VGIAVV
L
S
AVF
M
PM
A
F
MS
G
AT
G
E
IYR
Q
FSIT
LIS
S
M
LL
SV
F
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARF
N
TL
F
EKSTQH
----
Y
TNSTR
S
L
L
RCTGRY
M
V
VY
L
L
ICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
L
P
S
G
A
T
MVNTTKVLQ
Q
VT
DYY
LTKEKDN
V
Q
SVF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVT
AII
Q
RA
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AEL
G
TA
S
GFDME
L
LDNGNLGH
E
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
TG
V
RP
N
G
LE
DTPMFK
VNV
N
AA
KA
E
A
M
GV
A
L
S
DI
NQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
ML
P
DN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
GS
PR
L
ERY
N
GI
P
SME
I
LG
EA
AAGK
S
T
G
D
A
MKFMADLVAK
L
-
-
P
A
G
VGYS
W
T
G
--
LS
YQ
EA
L
SSNQAPA
L
Y
A
-
I
S
L
V
V
VFL
A
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LS
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
VEMM
Q
KE
----------
G
KTPI
EA
IIE
A
ARM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
VI
S
H
GAGSG
AQNA
VG
T
GVMGGM
FA
A
T
V
LAI
Y
fig|749549.3.peg.2217
Escherichia coli MS 198-1 (16-1018/1037)
AI
I
M
M
L
A
G
GLA
I
MN
LPV
A
QYP
Q
I
AP
P
T
I
T
I
S
A
T
YPGA
D
AQ
T
V
E
D
S
VT
Q
VIE
QN
M
NG
L
D
GLM
Y
MSS
T
S
DAA
G
NAS
ITL
T
FE
T
GT
S
PD
I
A
QV
QVQ
NK
LQ
L
A
MPS
LP
EAVQQQ
G
I
SVD-KSSSN
---
I
L
MVA
A
FI
S
DNGSLNQY
DI
A
D
Y
V
ASN
I
KDP
LS
RTA
GVG
S
V
QLF
G
SEY-AM
RI
W
LDP
QK
LN
KYN
L
VPSD
V
IS
Q
I
KVQ
N
NQISG
GQLGG
M
P
QAADQQLNAS
I
I
V
QTR
LQT
P
EEF
GK
I
L
L
KVQQ
DG
SQ
V
L
L
R
DVA
R
VE
L
G
A
E
DYSTV
A
RY
NGK
-
P
A
A
G
IA
I
K
L
AT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAY
FP
A
S
L
K
TVYP
YDTT
PF
I
EI
SI
Q
E
VFKT
L
V
EAI
I
LV
F
LV
M
YLFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
A
I
L
S
A
V
G
F
T
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
D
KLP
P
KE
A
TH
K
SMG
QIQ
R
AL
VGIAVV
L
S
AVF
M
PM
A
F
MS
G
AT
G
E
IYR
Q
FSIT
LIS
S
M
LL
SV
F
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARF
N
TL
F
EKSTQH
----
Y
TNSTR
S
L
L
RCTGRY
M
V
VY
L
L
ICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
L
P
S
G
A
T
MVNTTKVLQ
Q
VT
DYY
LTKEKDN
V
Q
SVF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVT
AII
Q
RA
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AEL
G
TA
S
GFDME
L
LDNGNLGH
E
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
TG
V
RP
N
G
LE
DTPMFK
VNV
N
AA
KA
E
A
M
GV
A
L
S
DI
NQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
ML
P
DN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
GS
PR
L
ERY
N
GI
P
SME
I
LG
EA
AAGK
S
T
G
D
A
MKFMADLVAK
L
-
-
P
A
G
VGYS
W
T
G
--
LS
YQ
EA
L
SSNQAPA
L
Y
A
-
I
S
L
V
V
VFL
A
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LS
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
VEMM
Q
KE
----------
G
KTPI
EA
IIE
A
ARM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
VI
S
H
GAGSG
AQNA
VG
T
GVMGGM
FA
A
T
V
LAI
Y
fig|585056.7.peg.4188
Escherichia coli UMN026 (16-1018/1037)
AI
I
M
M
L
A
G
GLA
I
MN
LPV
A
QYP
Q
I
AP
P
T
I
T
I
S
A
T
YPGA
D
AQ
T
V
E
D
S
VT
Q
VIE
QN
M
NG
L
D
GLM
Y
MSS
T
S
DAA
G
NAS
ITL
T
FE
T
GT
S
PD
I
A
QV
QVQ
NK
LQ
L
A
MPS
LP
EAVQQQ
G
I
SVD-KSSSN
---
I
L
MVA
A
FI
S
DNGSLNQY
DI
A
D
Y
V
ASN
I
KDP
LS
RTA
GVG
S
V
QLF
G
SEY-AM
RI
W
LDP
QK
LN
KYN
L
VPSD
V
IS
Q
I
KVQ
N
NQISG
GQLGG
M
P
QAADQQLNAS
I
I
V
QTR
LQT
P
EEF
GK
I
L
L
KVQQ
DG
SQ
V
L
L
R
DVA
R
VE
L
G
A
E
DYSTV
A
RY
NGK
-
P
A
A
G
IA
I
K
L
AT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAY
FP
A
S
L
K
TVYP
YDTT
PF
I
EI
SI
Q
E
VFKT
L
V
EAI
I
LV
F
LV
M
YLFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
A
I
L
S
A
V
G
F
T
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
D
KLP
P
KE
A
TH
K
SMG
QIQ
R
AL
VGIAVV
L
S
AVF
M
PM
A
F
MS
G
AT
G
E
IYR
Q
FSIT
LIS
S
M
LL
SV
F
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARF
N
TL
F
EKSTQH
----
Y
TNSTR
S
L
L
RCTGRY
M
V
VY
L
L
ICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
L
P
S
G
A
T
MVNTTKVLQ
Q
VT
DYY
LTKEKDN
V
Q
SVF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVT
AII
Q
RA
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AEL
G
TA
S
GFDME
L
LDNGNLGH
E
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
TG
V
RP
N
G
LE
DTPMFK
VNV
N
AA
KA
E
A
M
GV
A
L
S
DI
NQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
ML
P
DN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
GS
PR
L
ERY
N
GI
P
SME
I
LG
EA
AAGK
S
T
G
D
A
MKFMADLVAK
L
-
-
P
A
G
VGYS
W
T
G
--
LS
YQ
EA
L
SSNQAPA
L
Y
A
-
I
S
L
V
V
VFL
A
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LS
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
VEMM
Q
KE
----------
G
KTPI
EA
IIE
A
ARM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
VI
S
H
GAGSG
AQNA
VG
T
GVMGGM
FA
A
T
V
LAI
Y
fig|679205.4.peg.3318
Escherichia coli MS 124-1 (16-1018/1037)
AI
I
M
M
L
A
G
GLA
I
MN
LPV
A
QYP
Q
I
AP
P
T
I
T
V
S
A
T
YPGA
D
AQ
T
V
E
D
S
VT
Q
VIE
QN
M
NG
L
D
GLM
Y
MSS
T
S
DAA
G
NAS
ITL
T
FE
T
GT
S
PD
I
A
QV
QVQ
NK
LQ
L
A
MPS
LP
EAVQQQ
G
I
SVD-KSSSN
---
I
L
MVA
A
FI
S
DNGSLNQY
DI
A
D
Y
V
ASN
I
KDP
LS
RTA
GVG
S
V
QLF
G
SEY-AM
RI
W
LDP
QK
LN
KYN
L
VPSD
V
IS
Q
I
KVQ
N
NQISG
GQLGG
M
P
QAADQQLNAS
I
I
V
QTR
LQT
P
EEF
GK
I
L
L
KVQQ
DG
SQ
V
L
L
R
DVA
R
VE
L
G
A
E
DYSTV
A
RY
NGK
-
P
A
A
G
IA
I
K
L
AT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAY
FP
A
S
L
K
TVYP
YDTT
PF
I
EI
SI
Q
E
VFKT
L
V
EAI
I
LV
F
LV
M
YLFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
A
I
L
S
A
V
G
F
T
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
D
KLP
P
KE
A
TH
K
SMG
QIQ
R
AL
VGIAVV
L
S
AVF
M
PM
A
F
MS
G
AT
G
E
IYR
Q
FSIT
LIS
S
M
LL
SV
F
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARF
N
TL
F
EKSTQH
----
Y
TDSTR
S
L
L
RCTGRY
M
V
VY
L
L
ICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
L
P
S
G
A
T
MVNTTKVLQ
Q
VT
DYY
LIKEKDN
V
Q
SVF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVT
AII
Q
RA
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AEL
G
TA
S
GFDME
L
LDNGNLGH
E
K
L
TQARN
E
L
LSL
A
AQS
P
DQ
V
TG
V
RP
N
G
LE
DTPMFK
VNV
N
AA
KA
E
A
M
GV
A
L
S
DI
NQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
ML
P
DN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
GS
PR
L
ERY
N
GI
P
SME
I
LG
EA
AAGK
S
T
G
D
A
MKFMADLVAK
L
-
-
P
A
G
VGYS
W
T
G
--
LS
YQ
EA
L
SSNQAPA
L
Y
A
-
I
S
L
V
V
VFL
A
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LS
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
VEMM
Q
KE
----------
G
KTPI
EA
IIE
A
ARM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
VI
S
H
GAGSG
AQNA
VG
T
GVMGGM
FA
A
T
V
LAI
Y
fig|749533.3.peg.5066
Escherichia coli MS 84-1 (16-1018/1037)
AI
I
M
M
L
A
G
GLA
I
MN
LPV
A
QYP
Q
I
AP
P
T
I
T
V
S
A
T
YPGA
D
AQ
T
V
E
D
S
VT
Q
VIE
QN
M
NG
L
D
GLM
Y
MSS
T
S
DAA
G
NAS
ITL
T
FE
T
GT
S
PD
I
A
QV
QVQ
NK
LQ
L
A
MPS
LP
EAVQQQ
G
I
SVD-KSSSN
---
I
L
MVA
A
FI
S
DNGSLNQY
DI
A
D
Y
V
ASN
I
KDP
LS
RTA
GVG
S
V
QLF
G
SEY-AM
RI
W
LDP
QK
LN
KYN
L
VPSD
V
IS
Q
I
KVQ
N
NQISG
GQLGG
M
P
QAADQQLNAS
I
I
V
QTR
LQT
P
EEF
GK
I
L
L
KVQQ
DG
SQ
V
L
L
R
DVA
R
VE
L
G
A
E
DYSTV
A
RY
NGK
-
P
A
A
G
IA
I
K
L
AT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAY
FP
A
S
L
K
TVYP
YDTT
PF
I
EI
SI
Q
E
VFKT
L
V
EAI
I
LV
F
LV
M
YLFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
A
I
L
S
A
V
G
F
T
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
D
KLP
P
KE
A
TH
K
SMG
QIQ
R
AL
VGIAVV
L
S
AVF
M
PM
A
F
MS
G
AT
G
E
IYR
Q
FSIT
LIS
S
M
LL
SV
F
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARF
N
TL
F
EKSTQH
----
Y
TDSTR
S
L
L
RCTGRY
M
V
VY
L
L
ICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
L
P
S
G
A
T
MVNTTKVLQ
Q
VT
DYY
LIKEKDN
V
Q
SVF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVT
AII
Q
RA
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AEL
G
TA
S
GFDME
L
LDNGNLGH
E
K
L
TQARN
E
L
LSL
A
AQS
P
DQ
V
TG
V
RP
N
G
LE
DTPMFK
VNV
N
AA
KA
E
A
M
GV
A
L
S
DI
NQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
ML
P
DN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
GS
PR
L
ERY
N
GI
P
SME
I
LG
EA
AAGK
S
T
G
D
A
MKFMADLVAK
L
-
-
P
A
G
VGYS
W
T
G
--
LS
YQ
EA
L
SSNQAPA
L
Y
A
-
I
S
L
V
V
VFL
A
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LS
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
VEMM
Q
KE
----------
G
KTPI
EA
IIE
A
ARM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
VI
S
H
GAGSG
AQNA
VG
T
GVMGGM
FA
A
T
V
LAI
Y
fig|331111.12.peg.2647
Escherichia coli E24377A (17-1021/1040)
I
M
RPVA
TTL
L
----
M
V
A
I
L
L
A
G
IIG
Y
RA
LPV
S
AL
P
E
V
DY
P
T
I
Q
V
V
T
L
YPGA
S
PD
V
M
T
S
A
VT
A
PL
E
RQ
F
GQ
M
S
GL
K
Q
MSS
Q
S
SG-
G
ASV
ITL
Q
F
Q
L
TL
P
L
D
V
A
EQ
E
VQ
AA
IN
A
A
TNL
LP
SDLPNP
P
V
YSKVNPADP
---
P
I
MTL
A
VT
S
T--AMPMT
Q
V
E
D
M
V
ETR
V
AQK
I
S
QIS
GVG
L
V
TLS
G
GQRPAV
R
V
K
L
NA
QA
IA
ALG
L
TSET
V
RT
AI
TGA
N
VNSAK
G
S
L
--
-
-
--DGPSRAVT
L
S
A
NDQ
M
Q
S
A
EE
Y
RQ
L
I
I
AYQ-
N
G
AP
I
R
L
G
DVA
T
VE
Q
G
A
E
NSWLG
A
WA
N
K
E
-
Q
A
I
V
MN
V
Q
R
QP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TES
L
P
K
S
VK
VTVL
S
D
R
T
TN
I
RA
S
V
D
D
TQFE
L
M
M
AI
A
LV
V
M
I
I
YLFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
A
V
M
V
F
L
D
F
S
I
N
N
LT
L
M
A
L
T
I
A
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
K
GEK
P
LA
A
AL
K
GAG
E
I
G
F
TI
ISLTFS
L
I
AV
L
IP
L
L
F
MG
D
IV
G
R
LF
R
E
F
A
IT
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRAS
E
KM
F
DRIIAA
----
Y
GRGLA
KVL
NHPWLT
L
S
V
A
L
S
TLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VA
D
--
VILQDPA
V
Q
S
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQ
V
SR
T
QYQFT
L
QAT---SL
D
A
L
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
QD
KGLVAY
VNVD
RD
S
A
S
R
L
G
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
L
E
HNTEN
T
PG
L
AA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SF
N
V
PDNY
S
L
G
D
A
VQAIMDTEKT
L
N
L
P
V
D
ITTQ
F
Q
G
ST
LA
F
Q
SA
L
GS--TVW
L
I
V
-
A
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAE
R
EQ
----------
G
MSPR
D
A
IYQ
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
IV
S
Q
V
L
T
L
F
TT
P
VI
Y
L
L
fig|331111.3.peg.109
Escherichia coli E24377A (17-1021/1040)
I
M
RPVA
TTL
L
----
M
V
A
I
L
L
A
G
IIG
Y
RA
LPV
S
AL
P
E
V
DY
P
T
I
Q
V
V
T
L
YPGA
S
PD
V
M
T
S
A
VT
A
PL
E
RQ
F
GQ
M
S
GL
K
Q
MSS
Q
S
SG-
G
ASV
ITL
Q
F
Q
L
TL
P
L
D
V
A
EQ
E
VQ
AA
IN
A
A
TNL
LP
SDLPNP
P
V
YSKVNPADP
---
P
I
MTL
A
VT
S
T--AMPMT
Q
V
E
D
M
V
ETR
V
AQK
I
S
QIS
GVG
L
V
TLS
G
GQRPAV
R
V
K
L
NA
QA
IA
ALG
L
TSET
V
RT
AI
TGA
N
VNSAK
G
S
L
--
-
-
--DGPSRAVT
L
S
A
NDQ
M
Q
S
A
EE
Y
RQ
L
I
I
AYQ-
N
G
AP
I
R
L
G
DVA
T
VE
Q
G
A
E
NSWLG
A
WA
N
K
E
-
Q
A
I
V
MN
V
Q
R
QP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TES
L
P
K
S
VK
VTVL
S
D
R
T
TN
I
RA
S
V
D
D
TQFE
L
M
M
AI
A
LV
V
M
I
I
YLFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
A
V
M
V
F
L
D
F
S
I
N
N
LT
L
M
A
L
T
I
A
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
K
GEK
P
LA
A
AL
K
GAG
E
I
G
F
TI
ISLTFS
L
I
AV
L
IP
L
L
F
MG
D
IV
G
R
LF
R
E
F
A
IT
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRAS
E
KM
F
DRIIAA
----
Y
GRGLA
KVL
NHPWLT
L
S
V
A
L
S
TLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VA
D
--
VILQDPA
V
Q
S
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQ
V
SR
T
QYQFT
L
QAT---SL
D
A
L
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
QD
KGLVAY
VNVD
RD
S
A
S
R
L
G
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
L
E
HNTEN
T
PG
L
AA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SF
N
V
PDNY
S
L
G
D
A
VQAIMDTEKT
L
N
L
P
V
D
ITTQ
F
Q
G
ST
LA
F
Q
SA
L
GS--TVW
L
I
V
-
A
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAE
R
EQ
----------
G
MSPR
D
A
IYQ
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
IV
S
Q
V
L
T
L
F
TT
P
VI
Y
L
L
fig|749531.3.peg.1632
Escherichia coli MS 69-1 (16-1018/1037)
AI
I
M
M
L
A
G
GLA
I
MN
LPV
A
QYP
Q
I
AP
P
T
I
T
I
S
A
T
YPGA
D
AQ
T
V
E
D
S
VT
Q
VIE
QN
M
NG
L
D
GLM
Y
MSS
T
S
DAA
G
NAS
ITL
T
FE
T
GT
S
PD
I
A
QV
QVQ
NK
LQ
L
A
MPS
LP
EAVQQQ
G
I
SVD-KSSSN
---
I
L
MVA
A
FI
S
DNGSLNQY
DI
A
D
Y
V
ASN
I
KDP
LS
RTA
GVG
S
V
QLF
G
SEY-AM
RI
W
LDP
QK
LN
KYN
L
VPSD
V
IS
Q
I
KVQ
N
NQISG
GQLGG
M
P
QAADQQLNAS
I
I
V
QTR
LQT
P
EEF
GK
I
L
L
KVQQ
DG
SQ
V
L
L
R
DVA
R
VE
L
G
A
E
DYSTV
A
RY
NGK
-
P
A
A
G
IA
I
K
L
AT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAY
FP
A
S
L
K
TVYP
YDTT
PF
I
EI
SI
Q
E
VFKT
L
V
EAI
I
LV
F
LV
M
YLFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
A
I
L
S
A
V
G
F
T
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
D
KLP
P
KE
A
TH
K
SMG
QIQ
R
AL
VGIAVV
L
S
AVF
M
PM
A
F
MS
G
AT
G
E
IYR
Q
FSIT
LIS
S
M
LL
SV
F
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARF
N
TL
F
EKSTQH
----
Y
TDSTR
S
L
L
RCTGRY
M
V
VY
L
L
ICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
L
P
S
G
A
T
MVNTTKVLQ
Q
VT
DYY
LTKEKDN
V
Q
SVF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVT
AII
Q
RA
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AEL
G
TA
S
GFDME
L
LDNGNLGH
E
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
TG
V
RP
N
G
LE
DTPMFK
VNV
N
AA
KA
E
A
M
GV
A
L
S
DI
NQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
ML
P
DN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
GS
PR
L
ERY
N
GI
P
SME
I
LG
EA
AAGK
S
T
G
D
A
MKFMADLVAK
L
-
-
P
A
G
VGYS
W
T
G
--
LS
YQ
EA
L
SSNQAPA
L
Y
A
-
I
S
L
V
V
VFL
A
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LS
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
VEMM
Q
KE
----------
G
KTPI
EA
IIE
A
ARM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
VI
S
H
GAGSG
AQNA
VG
T
GVMGGM
FA
A
T
V
LAI
Y
fig|656437.3.peg.3955
Escherichia coli TA143 (16-1018/1037)
AI
I
M
M
L
A
G
GLA
I
MN
LPV
A
QYP
Q
I
AP
P
T
I
T
I
S
A
T
YPGA
D
AQ
T
V
E
D
S
VT
Q
VIE
QN
M
NG
L
D
GLM
Y
MSS
T
S
DAA
G
NAS
ITL
T
FE
T
GT
S
PD
I
A
QV
QVQ
NK
LQ
L
A
MPS
LP
EAVQQQ
G
I
SVD-KSSSN
---
I
L
MVA
A
FI
S
DNGSLNQY
DI
A
D
Y
V
ASN
I
KDP
LS
RTA
GVG
S
V
QLF
G
SEY-AM
RI
W
LDP
QK
LN
KYN
L
VPSD
V
IS
Q
I
KVQ
N
NQISG
GQLGG
M
P
QAADQQLNAS
I
I
V
QTR
LQT
P
EEF
GK
I
L
L
KVQQ
DG
SQ
V
L
L
R
DVA
R
VE
L
G
A
E
DYSTV
A
RY
NGK
-
P
A
A
G
IA
I
K
L
AT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAY
FP
A
S
L
K
TVYP
YDTT
PF
I
EI
SI
Q
E
VFKT
L
V
EAI
I
LV
F
LV
M
YLFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
A
I
L
S
A
V
G
F
T
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
D
KLP
P
KE
A
TH
K
SMG
QIQ
R
AL
VGIAVV
L
S
AVF
M
PM
A
F
MS
G
AT
G
E
IYR
Q
FSIT
LIS
S
M
LL
SV
F
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARF
N
TL
F
EKSTQH
----
Y
TDSTR
S
L
L
RCTGRY
M
V
VY
L
L
ICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
L
P
S
G
A
T
MVNTTKVLQ
Q
VT
DYY
LTKEKDN
V
Q
SVF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVT
AII
Q
RA
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AEL
G
TA
S
GFDME
L
LDNGNLGH
E
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
TG
V
RP
N
G
LE
DTPMFK
VNV
N
AA
KA
E
A
M
GV
A
L
S
DI
NQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
ML
P
DN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
GS
PR
L
ERY
N
GI
P
SME
I
LG
EA
AAGK
S
T
G
D
A
MKFMADLVAK
L
-
-
P
A
G
VGYS
W
T
G
--
LS
YQ
EA
L
SSNQAPA
L
Y
A
-
I
S
L
V
V
VFL
A
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LS
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
VEMM
Q
KE
----------
G
KTPI
EA
IIE
A
ARM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
VI
S
H
GAGSG
AQNA
VG
T
GVMGGM
FA
A
T
V
LAI
Y
fig|525281.3.peg.3878
Escherichia coli 83972 (17-1021/1040)
I
M
RPVA
TTL
L
----
M
V
A
I
L
L
A
G
IIG
Y
RA
LPV
S
AL
P
E
V
DY
P
T
I
Q
V
V
T
L
YPGA
S
PD
V
M
T
S
A
VT
A
PL
E
RQ
F
GQ
M
S
GL
K
Q
MSS
Q
S
SG-
G
ASV
ITL
Q
F
Q
L
TL
P
L
D
V
A
EQ
E
VQ
AA
IN
A
A
TNL
LP
SDLPNP
P
V
YSKVNPADP
---
P
I
MTL
A
VT
S
T--AMPMT
Q
V
E
D
M
V
ETR
V
AQK
I
S
QIS
GVG
L
V
TLS
G
GQRPAV
R
V
K
L
NA
QA
IA
ALG
L
TSET
V
RT
AI
TGA
N
VNSAK
G
S
L
--
-
-
--DGPSRAVT
L
S
A
NDQ
M
Q
S
A
EE
Y
RQ
L
I
I
AYQ-
N
G
AP
I
R
L
G
DVA
T
VE
Q
G
A
E
NSWLG
A
WA
N
K
E
-
Q
A
I
V
MN
V
Q
R
QP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TES
L
P
K
S
VK
VTVL
S
D
R
T
TN
I
RA
S
V
D
D
TQFE
L
M
M
AI
A
LV
V
M
I
I
YLFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
A
V
M
V
F
L
D
F
S
I
N
N
LT
L
M
A
L
T
I
A
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
K
GEK
P
LA
A
AL
K
GAG
E
I
G
F
TI
ISLTFS
L
I
AV
L
IP
L
L
F
MG
D
IV
G
R
LF
R
E
F
A
IT
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRAS
E
KM
F
DRIIAA
----
Y
GRGLA
KVL
NHPWLT
L
S
V
A
L
S
TLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VA
D
--
VILQDPA
V
Q
S
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQ
V
SR
T
QYQFT
L
QAT---SL
D
A
L
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
QD
KGLVAY
VNVD
RD
S
A
S
R
L
G
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
L
E
HNTEN
T
PG
L
AA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SF
N
V
PDNY
S
L
G
D
A
VQAIMDTEKT
L
N
L
P
V
D
ITTQ
F
Q
G
ST
LA
F
Q
SA
L
GS--TVW
L
I
V
-
A
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAE
R
EQ
----------
G
MSPR
D
A
IYQ
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
IV
S
Q
V
L
T
L
F
TT
P
VI
Y
L
L
fig|655817.3.peg.2518
Escherichia coli ABU 83972 (17-1021/1040)
I
M
RPVA
TTL
L
----
M
V
A
I
L
L
A
G
IIG
Y
RA
LPV
S
AL
P
E
V
DY
P
T
I
Q
V
V
T
L
YPGA
S
PD
V
M
T
S
A
VT
A
PL
E
RQ
F
GQ
M
S
GL
K
Q
MSS
Q
S
SG-
G
ASV
ITL
Q
F
Q
L
TL
P
L
D
V
A
EQ
E
VQ
AA
IN
A
A
TNL
LP
SDLPNP
P
V
YSKVNPADP
---
P
I
MTL
A
VT
S
T--AMPMT
Q
V
E
D
M
V
ETR
V
AQK
I
S
QIS
GVG
L
V
TLS
G
GQRPAV
R
V
K
L
NA
QA
IA
ALG
L
TSET
V
RT
AI
TGA
N
VNSAK
G
S
L
--
-
-
--DGPSRAVT
L
S
A
NDQ
M
Q
S
A
EE
Y
RQ
L
I
I
AYQ-
N
G
AP
I
R
L
G
DVA
T
VE
Q
G
A
E
NSWLG
A
WA
N
K
E
-
Q
A
I
V
MN
V
Q
R
QP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TES
L
P
K
S
VK
VTVL
S
D
R
T
TN
I
RA
S
V
D
D
TQFE
L
M
M
AI
A
LV
V
M
I
I
YLFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
A
V
M
V
F
L
D
F
S
I
N
N
LT
L
M
A
L
T
I
A
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
K
GEK
P
LA
A
AL
K
GAG
E
I
G
F
TI
ISLTFS
L
I
AV
L
IP
L
L
F
MG
D
IV
G
R
LF
R
E
F
A
IT
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRAS
E
KM
F
DRIIAA
----
Y
GRGLA
KVL
NHPWLT
L
S
V
A
L
S
TLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VA
D
--
VILQDPA
V
Q
S
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQ
V
SR
T
QYQFT
L
QAT---SL
D
A
L
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
QD
KGLVAY
VNVD
RD
S
A
S
R
L
G
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
L
E
HNTEN
T
PG
L
AA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SF
N
V
PDNY
S
L
G
D
A
VQAIMDTEKT
L
N
L
P
V
D
ITTQ
F
Q
G
ST
LA
F
Q
SA
L
GS--TVW
L
I
V
-
A
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAE
R
EQ
----------
G
MSPR
D
A
IYQ
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
IV
S
Q
V
L
T
L
F
TT
P
VI
Y
L
L
fig|344601.3.peg.1354
Escherichia coli B171 (16-1018/1037)
AI
I
M
M
L
A
G
GLA
I
MN
LPV
A
QYP
Q
I
AP
P
T
I
T
V
S
A
T
YPGA
D
AQ
T
V
E
D
S
VT
Q
VIE
QN
M
NG
L
D
GLM
Y
MSS
T
S
DAA
G
NAS
ITL
T
FE
T
GT
S
PD
I
A
QV
QVQ
NK
LQ
L
A
MPS
LP
EAVQQQ
G
I
SVD-KSSSN
---
I
L
MVA
A
FI
S
DNGSLNQY
DI
A
D
Y
V
ASN
I
KDP
LS
RTA
GVG
S
V
QLF
G
SEY-AM
RI
W
LDP
QK
LN
KYN
L
VPSD
V
IS
Q
I
KVQ
N
NQISG
GQLGG
M
P
QAADQQLNAS
I
I
V
QTR
LQT
P
EEF
GK
I
L
L
KVQQ
DG
SQ
V
L
L
R
DVA
R
VE
L
G
A
E
DYSTV
A
RY
NGK
-
P
A
A
G
IA
I
K
L
AT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAY
FP
A
S
L
K
TVYP
YDTT
PF
I
EI
SI
Q
E
VFKT
L
V
EAI
I
LV
F
LV
M
YLFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
A
I
L
S
A
V
G
F
T
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
D
KLP
P
KE
A
TH
K
SMG
QIQ
R
AL
VGIAVV
L
S
AVF
M
PM
A
F
MS
G
AT
G
E
IYR
Q
FSIT
LIS
S
M
LL
SV
F
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARF
N
TL
F
EKSTQH
----
Y
TDSTR
S
L
L
RCTGRY
M
V
VY
L
L
ICAGMAV
L
FLCT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
L
P
S
G
A
T
MVNTTKVLQ
Q
VT
DYY
LTKEKDN
V
Q
SVF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVT
AII
Q
RA
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AEL
G
TA
S
GFDME
L
LDNGNLGH
E
K
L
TQARN
E
L
LSL
A
AQS
P
DQ
V
TG
V
RP
N
G
LE
DTPMFK
VNV
N
AA
KA
E
A
M
GV
A
L
S
DI
NQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
ML
P
DN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
GS
PR
L
ERY
N
GI
P
SME
I
LG
EA
AAGK
S
T
G
D
A
MKFMADLVAK
L
-
-
P
A
G
VGYS
W
T
G
--
LS
YQ
EA
L
SSNQAPA
L
Y
A
-
I
S
L
V
V
VFL
A
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LS
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
VEMM
Q
KE
----------
G
KTPI
EA
IIE
A
ARM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
VI
S
H
GAGSG
AQNA
VG
T
GVMGGM
FA
A
T
V
LAI
Y
fig|344601.5.peg.1427
Escherichia coli B171 (16-1018/1037)
AI
I
M
M
L
A
G
GLA
I
MN
LPV
A
QYP
Q
I
AP
P
T
I
T
V
S
A
T
YPGA
D
AQ
T
V
E
D
S
VT
Q
VIE
QN
M
NG
L
D
GLM
Y
MSS
T
S
DAA
G
NAS
ITL
T
FE
T
GT
S
PD
I
A
QV
QVQ
NK
LQ
L
A
MPS
LP
EAVQQQ
G
I
SVD-KSSSN
---
I
L
MVA
A
FI
S
DNGSLNQY
DI
A
D
Y
V
ASN
I
KDP
LS
RTA
GVG
S
V
QLF
G
SEY-AM
RI
W
LDP
QK
LN
KYN
L
VPSD
V
IS
Q
I
KVQ
N
NQISG
GQLGG
M
P
QAADQQLNAS
I
I
V
QTR
LQT
P
EEF
GK
I
L
L
KVQQ
DG
SQ
V
L
L
R
DVA
R
VE
L
G
A
E
DYSTV
A
RY
NGK
-
P
A
A
G
IA
I
K
L
AT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAY
FP
A
S
L
K
TVYP
YDTT
PF
I
EI
SI
Q
E
VFKT
L
V
EAI
I
LV
F
LV
M
YLFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
A
I
L
S
A
V
G
F
T
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
D
KLP
P
KE
A
TH
K
SMG
QIQ
R
AL
VGIAVV
L
S
AVF
M
PM
A
F
MS
G
AT
G
E
IYR
Q
FSIT
LIS
S
M
LL
SV
F
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARF
N
TL
F
EKSTQH
----
Y
TDSTR
S
L
L
RCTGRY
M
V
VY
L
L
ICAGMAV
L
FLCT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
L
P
S
G
A
T
MVNTTKVLQ
Q
VT
DYY
LTKEKDN
V
Q
SVF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVT
AII
Q
RA
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AEL
G
TA
S
GFDME
L
LDNGNLGH
E
K
L
TQARN
E
L
LSL
A
AQS
P
DQ
V
TG
V
RP
N
G
LE
DTPMFK
VNV
N
AA
KA
E
A
M
GV
A
L
S
DI
NQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
ML
P
DN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
GS
PR
L
ERY
N
GI
P
SME
I
LG
EA
AAGK
S
T
G
D
A
MKFMADLVAK
L
-
-
P
A
G
VGYS
W
T
G
--
LS
YQ
EA
L
SSNQAPA
L
Y
A
-
I
S
L
V
V
VFL
A
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LS
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
VEMM
Q
KE
----------
G
KTPI
EA
IIE
A
ARM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
VI
S
H
GAGSG
AQNA
VG
T
GVMGGM
FA
A
T
V
LAI
Y
fig|340185.3.peg.86
Escherichia coli E22 (16-1018/1037)
AI
I
M
M
L
A
G
GLA
I
MN
LPV
A
QYP
Q
I
AP
P
T
I
T
V
S
A
T
YPGA
D
AQ
T
V
E
D
S
VT
Q
VIE
QN
M
NG
L
D
GLM
Y
MSS
T
S
DAA
G
NAS
ITL
T
FE
T
GT
S
PD
I
A
QV
QVQ
NK
LQ
L
A
MPS
LP
EAVQQQ
G
I
SVD-KSSSN
---
I
L
MVA
A
FI
S
DNGSLNQY
DI
A
D
Y
V
ASN
I
KDP
LS
RTA
GVG
S
V
QLF
G
SEY-AM
RI
W
LDP
QK
LN
KYN
L
VPSD
V
IS
Q
I
KVQ
N
NQISG
GQLGG
M
P
QAADQQLNAS
I
I
V
QTR
LQT
P
EEF
GK
I
L
L
KVQQ
DG
SQ
V
L
L
R
DVA
R
VE
L
G
A
E
DYSTV
A
RY
NGK
-
P
A
A
G
IA
I
K
L
AT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAY
FP
A
S
L
K
TVYP
YDTT
PF
I
EI
SI
Q
E
VFKT
L
V
EAI
I
LV
F
LV
M
YLFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
A
I
L
S
A
V
G
F
T
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
D
KLP
P
KE
A
TH
K
SMG
QIQ
R
AL
VGIAVV
L
S
AVF
M
PM
A
F
MS
G
AT
G
E
IYR
Q
FSIT
LIS
S
M
LL
SV
F
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARF
N
TL
F
EKSTQH
----
Y
TDSTR
S
L
L
RCTGRY
M
V
VY
L
L
ICAGMAV
L
FLCT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
L
P
S
G
A
T
MVNTTKVLQ
Q
VT
DYY
LTKEKDN
V
Q
SVF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVT
AII
Q
RA
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AEL
G
TA
S
GFDME
L
LDNGNLGH
E
K
L
TQARN
E
L
LSL
A
AQS
P
DQ
V
TG
V
RP
N
G
LE
DTPMFK
VNV
N
AA
KA
E
A
M
GV
A
L
S
DI
NQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
ML
P
DN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
GS
PR
L
ERY
N
GI
P
SME
I
LG
EA
AAGK
S
T
G
D
A
MKFMADLVAK
L
-
-
P
A
G
VGYS
W
T
G
--
LS
YQ
EA
L
SSNQAPA
L
Y
A
-
I
S
L
V
V
VFL
A
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LS
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
VEMM
Q
KE
----------
G
KTPI
EA
IIE
A
ARM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
VI
S
H
GAGSG
AQNA
VG
T
GVMGGM
FA
A
T
V
LAI
Y
fig|340185.4.peg.95
Escherichia coli E22 (16-1018/1037)
AI
I
M
M
L
A
G
GLA
I
MN
LPV
A
QYP
Q
I
AP
P
T
I
T
V
S
A
T
YPGA
D
AQ
T
V
E
D
S
VT
Q
VIE
QN
M
NG
L
D
GLM
Y
MSS
T
S
DAA
G
NAS
ITL
T
FE
T
GT
S
PD
I
A
QV
QVQ
NK
LQ
L
A
MPS
LP
EAVQQQ
G
I
SVD-KSSSN
---
I
L
MVA
A
FI
S
DNGSLNQY
DI
A
D
Y
V
ASN
I
KDP
LS
RTA
GVG
S
V
QLF
G
SEY-AM
RI
W
LDP
QK
LN
KYN
L
VPSD
V
IS
Q
I
KVQ
N
NQISG
GQLGG
M
P
QAADQQLNAS
I
I
V
QTR
LQT
P
EEF
GK
I
L
L
KVQQ
DG
SQ
V
L
L
R
DVA
R
VE
L
G
A
E
DYSTV
A
RY
NGK
-
P
A
A
G
IA
I
K
L
AT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAY
FP
A
S
L
K
TVYP
YDTT
PF
I
EI
SI
Q
E
VFKT
L
V
EAI
I
LV
F
LV
M
YLFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
A
I
L
S
A
V
G
F
T
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
D
KLP
P
KE
A
TH
K
SMG
QIQ
R
AL
VGIAVV
L
S
AVF
M
PM
A
F
MS
G
AT
G
E
IYR
Q
FSIT
LIS
S
M
LL
SV
F
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARF
N
TL
F
EKSTQH
----
Y
TDSTR
S
L
L
RCTGRY
M
V
VY
L
L
ICAGMAV
L
FLCT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
L
P
S
G
A
T
MVNTTKVLQ
Q
VT
DYY
LTKEKDN
V
Q
SVF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVT
AII
Q
RA
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AEL
G
TA
S
GFDME
L
LDNGNLGH
E
K
L
TQARN
E
L
LSL
A
AQS
P
DQ
V
TG
V
RP
N
G
LE
DTPMFK
VNV
N
AA
KA
E
A
M
GV
A
L
S
DI
NQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
ML
P
DN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
GS
PR
L
ERY
N
GI
P
SME
I
LG
EA
AAGK
S
T
G
D
A
MKFMADLVAK
L
-
-
P
A
G
VGYS
W
T
G
--
LS
YQ
EA
L
SSNQAPA
L
Y
A
-
I
S
L
V
V
VFL
A
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LS
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
VEMM
Q
KE
----------
G
KTPI
EA
IIE
A
ARM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
VI
S
H
GAGSG
AQNA
VG
T
GVMGGM
FA
A
T
V
LAI
Y
fig|585395.4.peg.4435
Escherichia coli O103:H2 str. 12009 (16-1018/1037)
AI
I
M
M
L
A
G
GLA
I
MN
LPV
A
QYP
Q
I
AP
P
T
I
T
V
S
A
T
YPGA
D
AQ
T
V
E
D
S
VT
Q
VIE
QN
M
NG
L
D
GLM
Y
MSS
T
S
DAA
G
NAS
ITL
T
FE
T
GT
S
PD
I
A
QV
QVQ
NK
LQ
L
A
MPS
LP
EAVQQQ
G
I
SVD-KSSSN
---
I
L
MVA
A
FI
S
DNGSLNQY
DI
A
D
Y
V
ASN
I
KDP
LS
RTA
GVG
S
V
QLF
G
SEY-AM
RI
W
LDP
QK
LN
KYN
L
VPSD
V
IS
Q
I
KVQ
N
NQISG
GQLGG
M
P
QAADQQLNAS
I
I
V
QTR
LQT
P
EEF
GK
I
L
L
KVQQ
DG
SQ
V
L
L
R
DVA
R
VE
L
G
A
E
DYSTV
A
RY
NGK
-
P
A
A
G
IA
I
K
L
AT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAY
FP
A
S
L
K
TVYP
YDTT
PF
I
EI
SI
Q
E
VFKT
L
V
EAI
I
LV
F
LV
M
YLFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
A
I
L
S
A
V
G
F
T
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
D
KLP
P
KE
A
TH
K
SMG
QIQ
R
AL
VGIAVV
L
S
AVF
M
PM
A
F
MS
G
AT
G
E
IYR
Q
FSIT
LIS
S
M
LL
SV
F
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARF
N
TL
F
EKSTQH
----
Y
TDSTR
S
L
L
RCTGRY
M
V
VY
L
L
ICAGMAV
L
FLCT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
L
P
S
G
A
T
MVNTTKVLQ
Q
VT
DYY
LTKEKDN
V
Q
SVF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVT
AII
Q
RA
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AEL
G
TA
S
GFDME
L
LDNGNLGH
E
K
L
TQARN
E
L
LSL
A
AQS
P
DQ
V
TG
V
RP
N
G
LE
DTPMFK
VNV
N
AA
KA
E
A
M
GV
A
L
S
DI
NQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
ML
P
DN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
GS
PR
L
ERY
N
GI
P
SME
I
LG
EA
AAGK
S
T
G
D
A
MKFMADLVAK
L
-
-
P
A
G
VGYS
W
T
G
--
LS
YQ
EA
L
SSNQAPA
L
Y
A
-
I
S
L
V
V
VFL
A
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LS
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
VEMM
Q
KE
----------
G
KTPI
EA
IIE
A
ARM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
VI
S
H
GAGSG
AQNA
VG
T
GVMGGM
FA
A
T
V
LAI
Y
fig|340184.3.peg.3957
Escherichia coli B7A (17-1021/1040)
I
M
RPVA
TTL
L
----
M
V
A
I
L
L
A
G
IIG
Y
RA
LPV
S
AL
P
E
V
DY
P
T
I
Q
V
V
T
L
YPGA
S
PD
V
M
T
S
A
VT
A
PL
E
RQ
F
GQ
M
S
GL
K
Q
MSS
Q
S
SG-
G
ASV
ITL
Q
F
Q
L
TL
P
L
D
V
A
EQ
E
VQ
AA
IN
A
A
TNL
LP
SDLPNP
P
V
YSKVNPADP
---
P
I
MTL
A
VT
S
T--AMPMT
Q
V
E
D
M
V
ETR
V
AQK
I
S
QIS
GVG
L
V
TLS
G
GQRPAV
R
V
K
L
NA
QA
IA
ALG
L
TSET
V
RT
AI
TGA
N
VNSAK
G
S
L
--
-
-
--DGPSRAVT
L
S
A
NDQ
M
Q
S
A
EE
Y
RQ
L
I
I
AYQ-
N
G
AP
I
R
L
G
DVA
T
VE
Q
G
A
E
NSWLG
A
WA
N
K
E
-
Q
A
I
V
MN
V
Q
R
QP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TES
L
P
K
S
VK
VTVL
S
D
R
T
TN
I
RA
S
V
D
D
TQFE
L
M
M
AI
A
LV
V
M
I
I
YLFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
A
V
M
V
F
L
D
F
S
I
N
N
LT
L
M
A
L
T
I
A
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
K
GEK
P
LA
A
AL
K
GAG
E
I
G
F
TI
ISLTFS
L
I
AV
L
IP
L
L
F
MG
D
IV
G
R
LF
R
E
F
A
IT
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRAS
E
KM
F
DRIIAA
----
Y
GRGLA
KVL
NHPWLT
L
S
V
A
L
S
TLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VA
D
--
VILQDPA
V
Q
S
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQ
V
SR
T
QYQFT
L
QAT---SL
D
A
L
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
QD
KGLVAY
VNVD
RD
S
A
S
R
L
G
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
L
E
HNTEI
T
PG
L
AA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KVEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SF
N
V
PDNY
S
L
G
D
A
VQAIMDTEKT
L
N
L
P
V
D
ITTQ
F
Q
G
ST
LA
F
Q
SA
L
GS--TVW
L
I
V
-
A
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAE
R
EQ
----------
G
MSPR
D
A
IYQ
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
IV
S
Q
V
L
T
L
F
TT
P
VI
Y
L
L
fig|340184.6.peg.4139
Escherichia coli B7A (17-1021/1040)
I
M
RPVA
TTL
L
----
M
V
A
I
L
L
A
G
IIG
Y
RA
LPV
S
AL
P
E
V
DY
P
T
I
Q
V
V
T
L
YPGA
S
PD
V
M
T
S
A
VT
A
PL
E
RQ
F
GQ
M
S
GL
K
Q
MSS
Q
S
SG-
G
ASV
ITL
Q
F
Q
L
TL
P
L
D
V
A
EQ
E
VQ
AA
IN
A
A
TNL
LP
SDLPNP
P
V
YSKVNPADP
---
P
I
MTL
A
VT
S
T--AMPMT
Q
V
E
D
M
V
ETR
V
AQK
I
S
QIS
GVG
L
V
TLS
G
GQRPAV
R
V
K
L
NA
QA
IA
ALG
L
TSET
V
RT
AI
TGA
N
VNSAK
G
S
L
--
-
-
--DGPSRAVT
L
S
A
NDQ
M
Q
S
A
EE
Y
RQ
L
I
I
AYQ-
N
G
AP
I
R
L
G
DVA
T
VE
Q
G
A
E
NSWLG
A
WA
N
K
E
-
Q
A
I
V
MN
V
Q
R
QP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TES
L
P
K
S
VK
VTVL
S
D
R
T
TN
I
RA
S
V
D
D
TQFE
L
M
M
AI
A
LV
V
M
I
I
YLFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
A
V
M
V
F
L
D
F
S
I
N
N
LT
L
M
A
L
T
I
A
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
K
GEK
P
LA
A
AL
K
GAG
E
I
G
F
TI
ISLTFS
L
I
AV
L
IP
L
L
F
MG
D
IV
G
R
LF
R
E
F
A
IT
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRAS
E
KM
F
DRIIAA
----
Y
GRGLA
KVL
NHPWLT
L
S
V
A
L
S
TLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VA
D
--
VILQDPA
V
Q
S
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQ
V
SR
T
QYQFT
L
QAT---SL
D
A
L
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
QD
KGLVAY
VNVD
RD
S
A
S
R
L
G
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
L
E
HNTEI
T
PG
L
AA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KVEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SF
N
V
PDNY
S
L
G
D
A
VQAIMDTEKT
L
N
L
P
V
D
ITTQ
F
Q
G
ST
LA
F
Q
SA
L
GS--TVW
L
I
V
-
A
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAE
R
EQ
----------
G
MSPR
D
A
IYQ
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
IV
S
Q
V
L
T
L
F
TT
P
VI
Y
L
L
fig|749537.3.peg.892
Escherichia coli MS 115-1 (17-1021/1040)
I
M
RPVA
TTL
L
----
M
V
A
I
L
L
A
G
IIG
Y
RA
LPV
S
AL
P
E
V
DY
P
T
I
Q
V
V
T
L
YPGA
S
PD
V
M
T
S
A
VT
A
PL
E
RQ
F
GQ
M
S
GL
K
Q
MSS
Q
S
SG-
G
ASV
ITL
Q
F
Q
L
TL
P
L
D
V
A
EQ
E
VQ
AA
IN
A
A
TNL
LP
SDLPNP
P
V
YSKVNPADP
---
P
I
MTL
A
VT
S
T--AMPMT
Q
V
E
D
M
V
ETR
V
AQK
I
S
QIS
GVG
L
V
TLS
G
GQRPAV
R
V
K
L
NA
QA
IA
ALG
L
TSET
V
RT
AI
TGA
N
VNSAK
G
S
L
--
-
-
--DGPSRAVT
L
S
A
NDQ
M
Q
S
A
EE
Y
RQ
L
I
I
AYQ-
N
G
AP
I
R
L
G
DVA
T
VE
Q
G
A
E
NSWLG
A
WA
N
K
E
-
Q
A
I
V
MN
V
Q
R
QP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TES
L
P
K
S
VK
VTVL
S
D
R
T
TN
I
RA
S
V
D
D
TQFE
L
M
M
AI
A
LV
V
M
I
I
YLFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
A
V
M
V
F
L
D
F
S
I
N
N
LT
L
M
A
L
T
I
A
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
K
GEK
P
LA
A
AL
K
GAG
E
I
G
F
TI
ISLTFS
L
I
AV
L
IP
L
L
F
MG
D
IV
G
R
LF
R
E
F
A
IT
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRAS
E
KM
F
DRIIAA
----
Y
GRGLA
KVL
NHPWLT
L
S
V
A
L
S
TLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VA
D
--
VILQDPA
V
Q
S
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQ
V
SR
T
QYQFT
L
QAT---SL
D
A
L
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
QD
KGLVAY
VNVD
RD
S
A
S
R
L
G
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
L
E
HNTEI
T
PG
L
AA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KVEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SF
N
V
PDNY
S
L
G
D
A
VQAIMDTEKT
L
N
L
P
V
D
ITTQ
F
Q
G
ST
LA
F
Q
SA
L
GS--TVW
L
I
V
-
A
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAE
R
EQ
----------
G
MSPR
D
A
IYQ
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
IV
S
Q
V
L
T
L
F
TT
P
VI
Y
L
L
fig|585396.4.peg.2889
Escherichia coli O111:H- str. 11128 (17-1021/1040)
I
M
RPVA
TTL
L
----
M
V
A
I
L
L
A
G
IIG
Y
RA
LPV
S
AL
P
E
V
DY
P
T
I
Q
V
V
T
L
YPGA
S
PD
V
M
T
S
A
VT
A
PL
E
RQ
F
GQ
M
S
GL
K
Q
MSS
Q
S
SG-
G
ASV
ITL
Q
F
Q
L
TL
P
L
D
V
A
EQ
E
VQ
AA
IN
A
A
TNL
LP
SDLPNP
P
V
YSKVNPADP
---
P
I
MTL
A
VT
S
T--AMPMT
Q
V
E
D
M
V
ETR
V
AQK
I
S
QIS
GVG
L
V
TLS
G
GQRPAV
R
V
K
L
NA
QA
IA
ALG
L
TSET
V
RT
AI
TGA
N
VNSAK
G
S
L
--
-
-
--DGPSRAVT
L
S
A
NDQ
M
Q
S
A
EE
Y
RQ
L
I
I
AYQ-
N
G
AP
I
R
L
G
DVA
T
VE
Q
G
A
E
NSWLG
A
WA
N
K
E
-
Q
A
I
V
MN
V
Q
R
QP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TES
L
P
K
S
VK
VTVL
S
D
R
T
TN
I
RA
S
V
D
D
TQFE
L
M
M
AI
A
LV
V
M
I
I
YLFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
A
V
M
V
F
L
D
F
S
I
N
N
LT
L
M
A
L
T
I
A
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
K
GEK
P
LA
A
AL
K
GAG
E
I
G
F
TI
ISLTFS
L
I
AV
L
IP
L
L
F
MG
D
IV
G
R
LF
R
E
F
A
IT
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRAS
E
KM
F
DRIIAA
----
Y
GRGLA
KVL
NHPWLT
L
S
V
A
L
S
TLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VA
D
--
VILQDPA
V
Q
S
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQ
V
SR
T
QYQFT
L
QAT---SL
D
A
L
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
QD
KGLVAY
VNVD
RD
S
A
S
R
L
G
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
L
E
HNTEI
T
PG
L
AA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KVEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SF
N
V
PDNY
S
L
G
D
A
VQAIMDTEKT
L
N
L
P
V
D
ITTQ
F
Q
G
ST
LA
F
Q
SA
L
GS--TVW
L
I
V
-
A
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAE
R
EQ
----------
G
MSPR
D
A
IYQ
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
IV
S
Q
V
L
T
L
F
TT
P
VI
Y
L
L
fig|409438.11.peg.2499
Escherichia coli SE11 (17-1021/1040)
I
M
RPVA
TTL
L
----
M
V
A
I
L
L
A
G
IIG
Y
RA
LPV
S
AL
P
E
V
DY
P
T
I
Q
V
V
T
L
YPGA
S
PD
V
M
T
S
A
VT
A
PL
E
RQ
F
GQ
M
S
GL
K
Q
MSS
Q
S
SG-
G
ASV
ITL
Q
F
Q
L
TL
P
L
D
V
A
EQ
E
VQ
AA
IN
A
A
TNL
LP
SDLPNP
P
V
YSKVNPADP
---
P
I
MTL
A
VT
S
T--AMPMT
Q
V
E
D
M
V
ETR
V
AQK
I
S
QIS
GVG
L
V
TLS
G
GQRPAV
R
V
K
L
NA
QA
IA
ALG
L
TSET
V
RT
AI
TGA
N
VNSAK
G
S
L
--
-
-
--DGPSRAVT
L
S
A
NDQ
M
Q
S
A
EE
Y
RQ
L
I
I
AYQ-
N
G
AP
I
R
L
G
DVA
T
VE
Q
G
A
E
NSWLG
A
WA
N
K
E
-
Q
A
I
V
MN
V
Q
R
QP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TES
L
P
K
S
VK
VTVL
S
D
R
T
TN
I
RA
S
V
D
D
TQFE
L
M
M
AI
A
LV
V
M
I
I
YLFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
A
V
M
V
F
L
D
F
S
I
N
N
LT
L
M
A
L
T
I
A
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
K
GEK
P
LA
A
AL
K
GAG
E
I
G
F
TI
ISLTFS
L
I
AV
L
IP
L
L
F
MG
D
IV
G
R
LF
R
E
F
A
IT
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRAS
E
KM
F
DRIIAA
----
Y
GRGLA
KVL
NHPWLT
L
S
V
A
L
S
TLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VA
D
--
VILQDPA
V
Q
S
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQ
V
SR
T
QYQFT
L
QAT---SL
D
A
L
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
QD
KGLVAY
VNVD
RD
S
A
S
R
L
G
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
L
E
HNTEI
T
PG
L
AA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KVEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SF
N
V
PDNY
S
L
G
D
A
VQAIMDTEKT
L
N
L
P
V
D
ITTQ
F
Q
G
ST
LA
F
Q
SA
L
GS--TVW
L
I
V
-
A
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAE
R
EQ
----------
G
MSPR
D
A
IYQ
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
IV
S
Q
V
L
T
L
F
TT
P
VI
Y
L
L
fig|573235.3.peg.4719
Escherichia coli O26:H11 str. 11368 (16-1018/1037)
AI
I
M
M
L
A
G
GLA
I
MN
LPV
A
QYP
Q
I
AP
P
T
I
T
V
S
A
T
YPGA
D
AQ
T
V
E
D
S
VT
Q
VIE
QN
M
NG
L
D
GLM
Y
MSS
T
S
DAA
G
NAS
ITL
T
FE
T
GT
S
PD
I
A
QV
QVQ
NK
LQ
L
A
MPS
LP
EAVQQQ
G
I
SVD-KSSSN
---
I
L
MVA
A
FI
S
DNGSLNQY
DI
A
D
Y
V
ASN
I
KDP
LS
RTA
GVG
S
V
QLF
G
SEY-AM
RI
W
LDP
QK
LN
KYN
L
VPSD
V
IS
Q
I
KVQ
N
NQISG
GQLGG
M
P
QAADQQLNAS
I
I
V
QTR
LQT
P
EEF
GK
I
L
L
KVQQ
DG
SQ
V
L
L
R
DVA
R
VE
L
G
A
E
DYSTV
A
RY
NGK
-
P
A
A
G
IA
I
K
L
AT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAY
FP
A
S
L
K
TVYP
YDTT
PF
I
EI
SI
Q
E
VFKT
L
V
EAI
I
LV
F
LV
M
YLFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
A
I
L
S
A
V
G
F
T
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
D
KLP
P
KE
A
TH
K
SMG
QIQ
R
AL
VGIAVV
L
S
AVF
M
PM
A
F
MS
G
AT
G
E
IYR
Q
FSIT
LIS
S
M
LL
SV
F
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARF
N
TL
F
EKSTQH
----
Y
TDSTR
S
L
L
RCTGRY
M
V
VY
L
L
ICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
L
P
S
G
A
T
MVNTTKVLQ
Q
VT
DYY
LTKEKDN
V
Q
SVF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVT
AII
Q
RA
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AEL
G
TA
S
GFDME
L
LDNGNLGH
E
K
L
TQARN
E
L
LSL
A
AQS
P
DQ
V
TG
V
RP
N
G
LE
DTPMFK
VNV
N
AA
KA
E
A
M
GV
A
L
S
DI
NQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
ML
P
DN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
GS
PR
L
ERY
N
GI
P
SME
I
LG
EA
AAGK
S
T
G
D
A
MKFMADLVAK
L
-
-
P
A
G
VGYS
W
T
G
--
LS
YQ
EA
L
SSNQAPA
L
Y
A
-
I
S
L
V
V
VFL
A
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LS
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
VEMM
Q
KE
----------
G
KTPI
EA
IIE
A
ARM
R
L
RPI
Q
MT
S
LA
F
I
L
G
V
LPL
VI
S
H
GAGSG
AQNA
VG
T
GVMGGM
FA
A
T
V
LAI
Y
fig|749537.3.peg.596
Escherichia coli MS 115-1 (16-1018/1037)
AI
I
M
M
L
A
G
GLA
I
MN
LPV
A
QYP
Q
I
AP
P
T
I
T
V
S
A
T
YPGA
D
AQ
T
V
E
D
S
VT
Q
VIE
QN
M
NG
L
D
GLM
Y
MSS
T
S
DAA
G
NAS
ITL
T
FE
T
GT
S
PD
I
A
QV
QVQ
NK
LQ
L
A
MPS
LP
EAVQQQ
G
I
SVD-KSSSN
---
I
L
MVA
A
FI
S
DNGSLNQY
DI
A
D
Y
V
ASN
I
KDP
LS
RTA
GVG
S
V
QLF
G
SEY-AM
RI
W
LDP
QK
LN
KYN
L
VPSD
V
IS
Q
I
KVQ
N
NQISG
GQLGG
M
P
QVADQQLNAS
I
I
V
QTR
LQT
P
EEF
GK
I
L
L
KVQQ
DG
SQ
V
L
L
R
DVA
R
VE
L
G
A
E
DYSTV
A
RY
NGK
-
P
A
A
G
IA
I
K
L
AT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAY
FP
A
S
L
K
TVYP
YDTT
PF
I
EI
SI
Q
E
VFKT
L
V
EAI
I
LV
F
LV
M
YLFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
A
I
L
S
A
V
G
F
T
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
D
KLP
P
KE
A
TH
K
SMG
QIQ
R
AL
VGIAVV
L
S
AVF
M
PM
A
F
MS
G
AT
G
E
IYR
Q
FSIT
LIS
S
M
LL
SV
F
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARF
N
TL
F
EKSTQH
----
Y
TDSTR
S
L
L
RCTGRY
M
V
VY
L
L
ICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
L
P
S
G
A
T
MVNTTKVLQ
Q
VT
DYY
LTKEKDN
V
Q
SVF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVT
AII
Q
RA
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AEL
G
TA
S
GFDME
L
LDNGNLGH
E
K
L
TQARN
E
L
LSL
A
AQS
P
DQ
V
TG
V
RP
N
G
LE
DTPMFK
VNV
N
AA
KA
E
A
M
GV
A
L
S
DI
NQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
ML
P
DN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
GS
PR
L
ERY
N
GI
P
SME
I
LG
EA
AAGK
S
T
G
D
A
MKFMADLVAK
L
-
-
P
A
G
VGYS
W
T
G
--
LS
YQ
EA
L
SSNQAPA
L
Y
A
-
I
S
L
V
V
VFL
A
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LS
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
VEMM
Q
KE
----------
G
KTPI
EA
IIE
A
ARM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
VI
S
H
GAGSG
AQNA
VG
T
GVMGGM
FA
A
T
V
LAI
Y
fig|585034.4.peg.3585
Escherichia coli IAI1 (16-1018/1037)
AI
I
M
M
L
A
G
GLA
I
MN
LPV
A
QYP
Q
I
AP
P
T
I
T
V
S
A
T
YPGA
D
AQ
T
V
E
D
S
VT
Q
VIE
QN
M
NG
L
D
GLM
Y
MSS
T
S
DAA
G
NAS
ITL
T
FE
T
GT
S
PD
I
A
QV
QVQ
NK
LQ
L
A
MPS
LP
EAVQQQ
G
I
SVD-KSSSN
---
I
L
MVA
A
FI
S
DNGSLNQY
DI
A
D
Y
V
ASN
I
KDP
LS
RTA
GVG
S
V
QLF
G
SEY-AM
RI
W
LDP
QK
LN
KYN
L
VPSD
V
IS
Q
I
KVQ
N
NQISG
GQLGG
M
P
QAADQQLNAS
I
I
V
QTR
LQT
P
EEF
GK
I
L
L
KVQQ
DG
SQ
V
L
L
R
DVA
R
VE
L
G
A
E
DYSTV
A
RY
NGK
-
P
A
A
G
IA
I
K
L
AT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAY
FP
A
S
L
K
TVYP
YDTT
PF
I
EI
SI
Q
E
VFKT
L
V
EAI
I
LV
F
LV
M
YLFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
A
I
L
S
A
V
G
F
T
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
D
KLP
P
KE
A
TH
K
SMG
QIQ
R
AL
VGIAVV
L
S
AVF
M
PM
A
F
MS
G
AT
G
E
IYR
Q
FSIT
LIS
S
M
LL
SV
F
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARF
N
TL
F
EKSTQH
----
Y
TDSTR
S
L
L
RCTGRY
M
V
VY
L
L
ICAGMAV
L
FLRT
P
AS
FLP
EE
D
Q
G
VFMTTA
Q
L
P
S
G
A
T
MVNTTKVLQ
Q
VT
DYY
LTKEKDN
V
Q
SVF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVT
AII
Q
RA
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AEL
G
TA
S
GFDME
L
LDNGNLGH
E
K
L
TQARN
E
L
LSL
A
AQS
P
DQ
V
TG
V
RP
N
G
LE
DTPMFK
VNV
N
AA
KA
E
A
M
GV
A
L
S
DI
NQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
ML
P
DN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
GS
PR
L
ERY
N
GI
P
SME
I
LG
EA
AAGK
S
T
G
D
A
MKFMADLVAK
L
-
-
P
A
G
VGYS
W
T
G
--
LS
YQ
EA
L
SSNQAPA
L
Y
A
-
I
S
L
V
V
VFL
A
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LS
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
VEMM
Q
KE
----------
G
KTPI
EA
IIE
A
ARM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
VI
S
H
GAGSG
AQNA
VG
T
GVMGGM
FA
A
T
V
LAI
Y
fig|585034.5.peg.3583
Escherichia coli IAI1 (16-1018/1037)
AI
I
M
M
L
A
G
GLA
I
MN
LPV
A
QYP
Q
I
AP
P
T
I
T
V
S
A
T
YPGA
D
AQ
T
V
E
D
S
VT
Q
VIE
QN
M
NG
L
D
GLM
Y
MSS
T
S
DAA
G
NAS
ITL
T
FE
T
GT
S
PD
I
A
QV
QVQ
NK
LQ
L
A
MPS
LP
EAVQQQ
G
I
SVD-KSSSN
---
I
L
MVA
A
FI
S
DNGSLNQY
DI
A
D
Y
V
ASN
I
KDP
LS
RTA
GVG
S
V
QLF
G
SEY-AM
RI
W
LDP
QK
LN
KYN
L
VPSD
V
IS
Q
I
KVQ
N
NQISG
GQLGG
M
P
QAADQQLNAS
I
I
V
QTR
LQT
P
EEF
GK
I
L
L
KVQQ
DG
SQ
V
L
L
R
DVA
R
VE
L
G
A
E
DYSTV
A
RY
NGK
-
P
A
A
G
IA
I
K
L
AT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAY
FP
A
S
L
K
TVYP
YDTT
PF
I
EI
SI
Q
E
VFKT
L
V
EAI
I
LV
F
LV
M
YLFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
A
I
L
S
A
V
G
F
T
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
D
KLP
P
KE
A
TH
K
SMG
QIQ
R
AL
VGIAVV
L
S
AVF
M
PM
A
F
MS
G
AT
G
E
IYR
Q
FSIT
LIS
S
M
LL
SV
F
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARF
N
TL
F
EKSTQH
----
Y
TDSTR
S
L
L
RCTGRY
M
V
VY
L
L
ICAGMAV
L
FLRT
P
AS
FLP
EE
D
Q
G
VFMTTA
Q
L
P
S
G
A
T
MVNTTKVLQ
Q
VT
DYY
LTKEKDN
V
Q
SVF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVT
AII
Q
RA
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AEL
G
TA
S
GFDME
L
LDNGNLGH
E
K
L
TQARN
E
L
LSL
A
AQS
P
DQ
V
TG
V
RP
N
G
LE
DTPMFK
VNV
N
AA
KA
E
A
M
GV
A
L
S
DI
NQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
ML
P
DN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
GS
PR
L
ERY
N
GI
P
SME
I
LG
EA
AAGK
S
T
G
D
A
MKFMADLVAK
L
-
-
P
A
G
VGYS
W
T
G
--
LS
YQ
EA
L
SSNQAPA
L
Y
A
-
I
S
L
V
V
VFL
A
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LS
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
VEMM
Q
KE
----------
G
KTPI
EA
IIE
A
ARM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
VI
S
H
GAGSG
AQNA
VG
T
GVMGGM
FA
A
T
V
LAI
Y
fig|656444.3.peg.4807
Escherichia coli TA280 (16-1018/1037)
AI
I
M
M
L
A
G
CLA
I
MN
LPV
A
QYP
Q
I
AP
P
T
I
T
V
S
A
T
YPGA
D
AQ
T
V
E
D
S
VT
Q
VIE
QN
M
NG
L
D
GLM
Y
MSS
T
S
DAA
G
NAS
ITL
T
FE
T
GT
S
PD
I
A
QV
QVQ
NK
LQ
L
A
MPS
LP
EAVQQQ
G
I
SVD-KSSSN
---
I
L
MVA
A
FI
S
DNGSLNQY
DI
A
D
Y
V
ASN
I
KDP
LS
RTA
GVG
S
V
QLF
G
SEY-AM
RI
W
LDP
QK
LN
KYN
L
VPSD
V
IS
Q
I
KVQ
N
NQISG
GQLGG
M
P
QAADQQLNAS
I
I
V
QTR
LQT
P
EEF
GK
I
L
L
KVQQ
DG
SQ
V
L
L
R
DVA
R
VE
L
G
A
E
DYSTV
A
RY
NGK
-
P
A
A
G
IA
I
K
L
AT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAY
FP
A
S
L
K
TVYP
YDTT
PF
I
EI
SI
Q
E
VFKT
L
V
EAI
I
LV
F
LV
M
YLFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
A
I
L
S
A
V
G
F
T
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
D
KLP
P
KE
A
TH
K
SMG
QIQ
R
AL
VGIAVV
L
S
AVF
M
PM
A
F
MS
G
AT
G
E
IYR
Q
FSIT
LIS
S
M
LL
SV
F
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARF
N
TL
F
EKSTQH
----
Y
TDSTR
S
L
L
RCTGRY
M
V
VY
L
L
ICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
L
P
S
G
A
T
MVNTTKVLQ
Q
VT
DYY
LTKEKDN
V
Q
SVF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVT
AII
Q
RA
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AEL
G
TA
S
GFDME
L
LDNGNLGH
E
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
TG
V
RP
N
G
LE
DTPMFK
VNV
N
AA
KA
E
A
M
GV
A
L
S
DI
NQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
ML
P
DN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
GS
PR
L
ERY
N
GI
P
SME
I
LG
EA
AAGK
S
T
G
D
A
MKFMADLVAK
L
-
-
P
A
G
VGYS
W
T
G
--
LS
YQ
EA
L
SSNQAPA
L
Y
A
-
I
S
L
V
V
VFL
A
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LS
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
VEMM
Q
KE
----------
G
KTPI
EA
IIE
A
ARM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
VI
S
H
GAGSG
AQNA
VG
T
GVMGGM
FA
A
T
V
LAI
Y
fig|1040638.4.peg.2143
Escherichia coli O104:H4 str. LB226692 (16-1018/1037)
AI
I
M
M
L
A
G
GLA
I
MN
LPV
A
QYP
Q
I
AP
P
T
I
T
V
S
A
T
YPGA
D
AQ
T
V
E
D
S
VT
Q
VIE
QN
M
NG
L
D
GLM
Y
MSS
T
S
DAA
G
NAS
ITL
T
FE
T
GT
S
PD
I
A
QV
QVQ
NK
LQ
L
A
MPS
LP
EAVQQQ
G
I
SVD-KSSSN
---
I
L
MVA
A
FI
S
DNGSLNQY
DI
A
D
Y
V
ASN
I
KDP
LS
RTA
GVG
S
V
QLF
G
SEY-AM
RI
W
LDP
QK
LN
KYN
L
VPSD
V
IS
Q
I
KVQ
N
NQISG
GQLGG
M
P
QAADQQLNAS
I
I
V
QTR
LQT
P
EEF
GK
I
L
L
KVQQ
DG
SQ
V
L
L
R
DVA
R
VE
L
G
A
E
DYSTV
A
RY
NGK
-
P
A
A
G
IA
I
K
L
AT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAY
FP
A
S
L
K
TVYP
YDTT
PF
I
EI
SI
Q
E
VFKT
L
V
EAI
I
LV
F
LV
M
YLFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
A
I
L
S
A
V
G
F
T
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
D
KLP
P
KE
A
TH
K
SMG
QIQ
R
AL
VGIAVV
L
S
AVF
M
PM
A
F
MS
G
AT
G
E
IYR
Q
FSIT
LIS
S
M
LL
SV
F
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARF
N
TL
F
EKSTQH
----
Y
TDSTR
S
L
L
RCTGRY
M
V
VY
L
L
ICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
L
P
S
G
A
T
MVNTTKVLQ
Q
VT
DYY
LTKEKDN
V
Q
SVF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVT
AII
Q
RA
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AEL
G
TA
S
GFDME
L
LDNGNLGH
E
K
L
TQARN
E
L
LSL
A
AQS
P
DQ
V
TG
V
RP
N
G
LE
DTPMFK
VNV
N
AA
KA
E
A
M
GV
A
L
S
DI
NQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
ML
P
DN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
GS
PR
L
ERY
N
GI
P
SME
I
LG
EA
AAGK
S
T
G
D
A
MKFMADLVAK
L
-
-
P
A
G
VGYS
W
T
G
--
LS
YQ
EA
L
SSNQAPA
L
Y
A
-
I
S
L
V
V
VFL
A
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LS
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
VEMM
Q
KE
----------
G
KTPI
EA
IIE
A
ARM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
VI
S
H
GAGSG
AQNA
VG
T
GVMGGM
FA
A
T
V
LAI
Y
fig|585055.6.peg.3988
Escherichia coli 55989 (16-1018/1037)
AI
I
M
M
L
A
G
GLA
I
MN
LPV
A
QYP
Q
I
AP
P
T
I
T
V
S
A
T
YPGA
D
AQ
T
V
E
D
S
VT
Q
VIE
QN
M
NG
L
D
GLM
Y
MSS
T
S
DAA
G
NAS
ITL
T
FE
T
GT
S
PD
I
A
QV
QVQ
NK
LQ
L
A
MPS
LP
EAVQQQ
G
I
SVD-KSSSN
---
I
L
MVA
A
FI
S
DNGSLNQY
DI
A
D
Y
V
ASN
I
KDP
LS
RTA
GVG
S
V
QLF
G
SEY-AM
RI
W
LDP
QK
LN
KYN
L
VPSD
V
IS
Q
I
KVQ
N
NQISG
GQLGG
M
P
QAADQQLNAS
I
I
V
QTR
LQT
P
EEF
GK
I
L
L
KVQQ
DG
SQ
V
L
L
R
DVA
R
VE
L
G
A
E
DYSTV
A
RY
NGK
-
P
A
A
G
IA
I
K
L
AT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAY
FP
A
S
L
K
TVYP
YDTT
PF
I
EI
SI
Q
E
VFKT
L
V
EAI
I
LV
F
LV
M
YLFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
A
I
L
S
A
V
G
F
T
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
D
KLP
P
KE
A
TH
K
SMG
QIQ
R
AL
VGIAVV
L
S
AVF
M
PM
A
F
MS
G
AT
G
E
IYR
Q
FSIT
LIS
S
M
LL
SV
F
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARF
N
TL
F
EKSTQH
----
Y
TDSTR
S
L
L
RCTGRY
M
V
VY
L
L
ICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
L
P
S
G
A
T
MVNTTKVLQ
Q
VT
DYY
LTKEKDN
V
Q
SVF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVT
AII
Q
RA
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AEL
G
TA
S
GFDME
L
LDNGNLGH
E
K
L
TQARN
E
L
LSL
A
AQS
P
DQ
V
TG
V
RP
N
G
LE
DTPMFK
VNV
N
AA
KA
E
A
M
GV
A
L
S
DI
NQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
ML
P
DN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
GS
PR
L
ERY
N
GI
P
SME
I
LG
EA
AAGK
S
T
G
D
A
MKFMADLVAK
L
-
-
P
A
G
VGYS
W
T
G
--
LS
YQ
EA
L
SSNQAPA
L
Y
A
-
I
S
L
V
V
VFL
A
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LS
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
VEMM
Q
KE
----------
G
KTPI
EA
IIE
A
ARM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
VI
S
H
GAGSG
AQNA
VG
T
GVMGGM
FA
A
T
V
LAI
Y
fig|585055.8.peg.3990
Escherichia coli 55989 (16-1018/1037)
AI
I
M
M
L
A
G
GLA
I
MN
LPV
A
QYP
Q
I
AP
P
T
I
T
V
S
A
T
YPGA
D
AQ
T
V
E
D
S
VT
Q
VIE
QN
M
NG
L
D
GLM
Y
MSS
T
S
DAA
G
NAS
ITL
T
FE
T
GT
S
PD
I
A
QV
QVQ
NK
LQ
L
A
MPS
LP
EAVQQQ
G
I
SVD-KSSSN
---
I
L
MVA
A
FI
S
DNGSLNQY
DI
A
D
Y
V
ASN
I
KDP
LS
RTA
GVG
S
V
QLF
G
SEY-AM
RI
W
LDP
QK
LN
KYN
L
VPSD
V
IS
Q
I
KVQ
N
NQISG
GQLGG
M
P
QAADQQLNAS
I
I
V
QTR
LQT
P
EEF
GK
I
L
L
KVQQ
DG
SQ
V
L
L
R
DVA
R
VE
L
G
A
E
DYSTV
A
RY
NGK
-
P
A
A
G
IA
I
K
L
AT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAY
FP
A
S
L
K
TVYP
YDTT
PF
I
EI
SI
Q
E
VFKT
L
V
EAI
I
LV
F
LV
M
YLFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
A
I
L
S
A
V
G
F
T
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
D
KLP
P
KE
A
TH
K
SMG
QIQ
R
AL
VGIAVV
L
S
AVF
M
PM
A
F
MS
G
AT
G
E
IYR
Q
FSIT
LIS
S
M
LL
SV
F
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARF
N
TL
F
EKSTQH
----
Y
TDSTR
S
L
L
RCTGRY
M
V
VY
L
L
ICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
L
P
S
G
A
T
MVNTTKVLQ
Q
VT
DYY
LTKEKDN
V
Q
SVF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVT
AII
Q
RA
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AEL
G
TA
S
GFDME
L
LDNGNLGH
E
K
L
TQARN
E
L
LSL
A
AQS
P
DQ
V
TG
V
RP
N
G
LE
DTPMFK
VNV
N
AA
KA
E
A
M
GV
A
L
S
DI
NQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
ML
P
DN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
GS
PR
L
ERY
N
GI
P
SME
I
LG
EA
AAGK
S
T
G
D
A
MKFMADLVAK
L
-
-
P
A
G
VGYS
W
T
G
--
LS
YQ
EA
L
SSNQAPA
L
Y
A
-
I
S
L
V
V
VFL
A
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LS
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
VEMM
Q
KE
----------
G
KTPI
EA
IIE
A
ARM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
VI
S
H
GAGSG
AQNA
VG
T
GVMGGM
FA
A
T
V
LAI
Y
fig|550672.3.peg.3562
Escherichia coli B088 (16-1018/1037)
AI
I
M
M
L
A
G
GLA
I
MN
LPV
A
QYP
Q
I
AP
P
T
I
T
V
S
A
T
YPGA
D
AQ
T
V
E
D
S
VT
Q
VIE
QN
M
NG
L
D
GLM
Y
MSS
T
S
DAA
G
NAS
ITL
T
FE
T
GT
S
PD
I
A
QV
QVQ
NK
LQ
L
A
MPS
LP
EAVQQQ
G
I
SVD-KSSSN
---
I
L
MVA
A
FI
S
DNGSLNQY
DI
A
D
Y
V
ASN
I
KDP
LS
RTA
GVG
S
V
QLF
G
SEY-AM
RI
W
LDP
QK
LN
KYN
L
VPSD
V
IS
Q
I
KVQ
N
NQISG
GQLGG
M
P
QAADQQLNAS
I
I
V
QTR
LQT
P
EEF
GK
I
L
L
KVQQ
DG
SQ
V
L
L
R
DVA
R
VE
L
G
A
E
DYSTV
A
RY
NGK
-
P
A
A
G
IA
I
K
L
AT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAY
FP
A
S
L
K
TVYP
YDTT
PF
I
EI
SI
Q
E
VFKT
L
V
EAI
I
LV
F
LV
M
YLFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
A
I
L
S
A
V
G
F
T
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
D
KLP
P
KE
A
TH
K
SMG
QIQ
R
AL
VGIAVV
L
S
AVF
M
PM
A
F
MS
G
AT
G
E
IYR
Q
FSIT
LIS
S
M
LL
SV
F
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARF
N
TL
F
EKSTQH
----
Y
TDSTR
S
L
L
RCTGRY
M
V
VY
L
L
ICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
L
P
S
G
A
T
MVNTTKVLQ
Q
VT
DYY
LTKEKDN
V
Q
SVF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVT
AII
Q
RA
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AEL
G
TA
S
GFDME
L
LDNGNLGH
E
K
L
TQARN
E
L
LSL
A
AQS
P
DQ
V
TG
V
RP
N
G
LE
DTPMFK
VNV
N
AA
KA
E
A
M
GV
A
L
S
DI
NQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
ML
P
DN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
GS
PR
L
ERY
N
GI
P
SME
I
LG
EA
AAGK
S
T
G
D
A
MKFMADLVAK
L
-
-
P
A
G
VGYS
W
T
G
--
LS
YQ
EA
L
SSNQAPA
L
Y
A
-
I
S
L
V
V
VFL
A
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LS
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
VEMM
Q
KE
----------
G
KTPI
EA
IIE
A
ARM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
VI
S
H
GAGSG
AQNA
VG
T
GVMGGM
FA
A
T
V
LAI
Y
fig|340184.3.peg.341
Escherichia coli B7A (16-1018/1037)
AI
I
M
M
L
A
G
GLA
I
MN
LPV
A
QYP
Q
I
AP
P
T
I
T
V
S
A
T
YPGA
D
AQ
T
V
E
D
S
VT
Q
VIE
QN
M
NG
L
D
GLM
Y
MSS
T
S
DAA
G
NAS
ITL
T
FE
T
GT
S
PD
I
A
QV
QVQ
NK
LQ
L
A
MPS
LP
EAVQQQ
G
I
SVD-KSSSN
---
I
L
MVA
A
FI
S
DNGSLNQY
DI
A
D
Y
V
ASN
I
KDP
LS
RTA
GVG
S
V
QLF
G
SEY-AM
RI
W
LDP
QK
LN
KYN
L
VPSD
V
IS
Q
I
KVQ
N
NQISG
GQLGG
M
P
QAADQQLNAS
I
I
V
QTR
LQT
P
EEF
GK
I
L
L
KVQQ
DG
SQ
V
L
L
R
DVA
R
VE
L
G
A
E
DYSTV
A
RY
NGK
-
P
A
A
G
IA
I
K
L
AT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAY
FP
A
S
L
K
TVYP
YDTT
PF
I
EI
SI
Q
E
VFKT
L
V
EAI
I
LV
F
LV
M
YLFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
A
I
L
S
A
V
G
F
T
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
D
KLP
P
KE
A
TH
K
SMG
QIQ
R
AL
VGIAVV
L
S
AVF
M
PM
A
F
MS
G
AT
G
E
IYR
Q
FSIT
LIS
S
M
LL
SV
F
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARF
N
TL
F
EKSTQH
----
Y
TDSTR
S
L
L
RCTGRY
M
V
VY
L
L
ICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
L
P
S
G
A
T
MVNTTKVLQ
Q
VT
DYY
LTKEKDN
V
Q
SVF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVT
AII
Q
RA
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AEL
G
TA
S
GFDME
L
LDNGNLGH
E
K
L
TQARN
E
L
LSL
A
AQS
P
DQ
V
TG
V
RP
N
G
LE
DTPMFK
VNV
N
AA
KA
E
A
M
GV
A
L
S
DI
NQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
ML
P
DN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
GS
PR
L
ERY
N
GI
P
SME
I
LG
EA
AAGK
S
T
G
D
A
MKFMADLVAK
L
-
-
P
A
G
VGYS
W
T
G
--
LS
YQ
EA
L
SSNQAPA
L
Y
A
-
I
S
L
V
V
VFL
A
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LS
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
VEMM
Q
KE
----------
G
KTPI
EA
IIE
A
ARM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
VI
S
H
GAGSG
AQNA
VG
T
GVMGGM
FA
A
T
V
LAI
Y
fig|340184.6.peg.355
Escherichia coli B7A (16-1018/1037)
AI
I
M
M
L
A
G
GLA
I
MN
LPV
A
QYP
Q
I
AP
P
T
I
T
V
S
A
T
YPGA
D
AQ
T
V
E
D
S
VT
Q
VIE
QN
M
NG
L
D
GLM
Y
MSS
T
S
DAA
G
NAS
ITL
T
FE
T
GT
S
PD
I
A
QV
QVQ
NK
LQ
L
A
MPS
LP
EAVQQQ
G
I
SVD-KSSSN
---
I
L
MVA
A
FI
S
DNGSLNQY
DI
A
D
Y
V
ASN
I
KDP
LS
RTA
GVG
S
V
QLF
G
SEY-AM
RI
W
LDP
QK
LN
KYN
L
VPSD
V
IS
Q
I
KVQ
N
NQISG
GQLGG
M
P
QAADQQLNAS
I
I
V
QTR
LQT
P
EEF
GK
I
L
L
KVQQ
DG
SQ
V
L
L
R
DVA
R
VE
L
G
A
E
DYSTV
A
RY
NGK
-
P
A
A
G
IA
I
K
L
AT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAY
FP
A
S
L
K
TVYP
YDTT
PF
I
EI
SI
Q
E
VFKT
L
V
EAI
I
LV
F
LV
M
YLFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
A
I
L
S
A
V
G
F
T
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
D
KLP
P
KE
A
TH
K
SMG
QIQ
R
AL
VGIAVV
L
S
AVF
M
PM
A
F
MS
G
AT
G
E
IYR
Q
FSIT
LIS
S
M
LL
SV
F
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARF
N
TL
F
EKSTQH
----
Y
TDSTR
S
L
L
RCTGRY
M
V
VY
L
L
ICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
L
P
S
G
A
T
MVNTTKVLQ
Q
VT
DYY
LTKEKDN
V
Q
SVF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVT
AII
Q
RA
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AEL
G
TA
S
GFDME
L
LDNGNLGH
E
K
L
TQARN
E
L
LSL
A
AQS
P
DQ
V
TG
V
RP
N
G
LE
DTPMFK
VNV
N
AA
KA
E
A
M
GV
A
L
S
DI
NQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
ML
P
DN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
GS
PR
L
ERY
N
GI
P
SME
I
LG
EA
AAGK
S
T
G
D
A
MKFMADLVAK
L
-
-
P
A
G
VGYS
W
T
G
--
LS
YQ
EA
L
SSNQAPA
L
Y
A
-
I
S
L
V
V
VFL
A
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LS
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
VEMM
Q
KE
----------
G
KTPI
EA
IIE
A
ARM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
VI
S
H
GAGSG
AQNA
VG
T
GVMGGM
FA
A
T
V
LAI
Y
fig|340186.3.peg.1646
Escherichia coli E110019 (16-1018/1037)
AI
I
M
M
L
A
G
GLA
I
MN
LPV
A
QYP
Q
I
AP
P
T
I
T
V
S
A
T
YPGA
D
AQ
T
V
E
D
S
VT
Q
VIE
QN
M
NG
L
D
GLM
Y
MSS
T
S
DAA
G
NAS
ITL
T
FE
T
GT
S
PD
I
A
QV
QVQ
NK
LQ
L
A
MPS
LP
EAVQQQ
G
I
SVD-KSSSN
---
I
L
MVA
A
FI
S
DNGSLNQY
DI
A
D
Y
V
ASN
I
KDP
LS
RTA
GVG
S
V
QLF
G
SEY-AM
RI
W
LDP
QK
LN
KYN
L
VPSD
V
IS
Q
I
KVQ
N
NQISG
GQLGG
M
P
QAADQQLNAS
I
I
V
QTR
LQT
P
EEF
GK
I
L
L
KVQQ
DG
SQ
V
L
L
R
DVA
R
VE
L
G
A
E
DYSTV
A
RY
NGK
-
P
A
A
G
IA
I
K
L
AT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAY
FP
A
S
L
K
TVYP
YDTT
PF
I
EI
SI
Q
E
VFKT
L
V
EAI
I
LV
F
LV
M
YLFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
A
I
L
S
A
V
G
F
T
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
D
KLP
P
KE
A
TH
K
SMG
QIQ
R
AL
VGIAVV
L
S
AVF
M
PM
A
F
MS
G
AT
G
E
IYR
Q
FSIT
LIS
S
M
LL
SV
F
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARF
N
TL
F
EKSTQH
----
Y
TDSTR
S
L
L
RCTGRY
M
V
VY
L
L
ICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
L
P
S
G
A
T
MVNTTKVLQ
Q
VT
DYY
LTKEKDN
V
Q
SVF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVT
AII
Q
RA
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AEL
G
TA
S
GFDME
L
LDNGNLGH
E
K
L
TQARN
E
L
LSL
A
AQS
P
DQ
V
TG
V
RP
N
G
LE
DTPMFK
VNV
N
AA
KA
E
A
M
GV
A
L
S
DI
NQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
ML
P
DN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
GS
PR
L
ERY
N
GI
P
SME
I
LG
EA
AAGK
S
T
G
D
A
MKFMADLVAK
L
-
-
P
A
G
VGYS
W
T
G
--
LS
YQ
EA
L
SSNQAPA
L
Y
A
-
I
S
L
V
V
VFL
A
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LS
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
VEMM
Q
KE
----------
G
KTPI
EA
IIE
A
ARM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
VI
S
H
GAGSG
AQNA
VG
T
GVMGGM
FA
A
T
V
LAI
Y
fig|340186.5.peg.1697
Escherichia coli E110019 (16-1018/1037)
AI
I
M
M
L
A
G
GLA
I
MN
LPV
A
QYP
Q
I
AP
P
T
I
T
V
S
A
T
YPGA
D
AQ
T
V
E
D
S
VT
Q
VIE
QN
M
NG
L
D
GLM
Y
MSS
T
S
DAA
G
NAS
ITL
T
FE
T
GT
S
PD
I
A
QV
QVQ
NK
LQ
L
A
MPS
LP
EAVQQQ
G
I
SVD-KSSSN
---
I
L
MVA
A
FI
S
DNGSLNQY
DI
A
D
Y
V
ASN
I
KDP
LS
RTA
GVG
S
V
QLF
G
SEY-AM
RI
W
LDP
QK
LN
KYN
L
VPSD
V
IS
Q
I
KVQ
N
NQISG
GQLGG
M
P
QAADQQLNAS
I
I
V
QTR
LQT
P
EEF
GK
I
L
L
KVQQ
DG
SQ
V
L
L
R
DVA
R
VE
L
G
A
E
DYSTV
A
RY
NGK
-
P
A
A
G
IA
I
K
L
AT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAY
FP
A
S
L
K
TVYP
YDTT
PF
I
EI
SI
Q
E
VFKT
L
V
EAI
I
LV
F
LV
M
YLFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
A
I
L
S
A
V
G
F
T
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
D
KLP
P
KE
A
TH
K
SMG
QIQ
R
AL
VGIAVV
L
S
AVF
M
PM
A
F
MS
G
AT
G
E
IYR
Q
FSIT
LIS
S
M
LL
SV
F
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARF
N
TL
F
EKSTQH
----
Y
TDSTR
S
L
L
RCTGRY
M
V
VY
L
L
ICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
L
P
S
G
A
T
MVNTTKVLQ
Q
VT
DYY
LTKEKDN
V
Q
SVF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVT
AII
Q
RA
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AEL
G
TA
S
GFDME
L
LDNGNLGH
E
K
L
TQARN
E
L
LSL
A
AQS
P
DQ
V
TG
V
RP
N
G
LE
DTPMFK
VNV
N
AA
KA
E
A
M
GV
A
L
S
DI
NQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
ML
P
DN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
GS
PR
L
ERY
N
GI
P
SME
I
LG
EA
AAGK
S
T
G
D
A
MKFMADLVAK
L
-
-
P
A
G
VGYS
W
T
G
--
LS
YQ
EA
L
SSNQAPA
L
Y
A
-
I
S
L
V
V
VFL
A
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LS
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
VEMM
Q
KE
----------
G
KTPI
EA
IIE
A
ARM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
VI
S
H
GAGSG
AQNA
VG
T
GVMGGM
FA
A
T
V
LAI
Y
fig|331111.12.peg.4241
Escherichia coli E24377A (16-1018/1037)
AI
I
M
M
L
A
G
GLA
I
MN
LPV
A
QYP
Q
I
AP
P
T
I
T
V
S
A
T
YPGA
D
AQ
T
V
E
D
S
VT
Q
VIE
QN
M
NG
L
D
GLM
Y
MSS
T
S
DAA
G
NAS
ITL
T
FE
T
GT
S
PD
I
A
QV
QVQ
NK
LQ
L
A
MPS
LP
EAVQQQ
G
I
SVD-KSSSN
---
I
L
MVA
A
FI
S
DNGSLNQY
DI
A
D
Y
V
ASN
I
KDP
LS
RTA
GVG
S
V
QLF
G
SEY-AM
RI
W
LDP
QK
LN
KYN
L
VPSD
V
IS
Q
I
KVQ
N
NQISG
GQLGG
M
P
QAADQQLNAS
I
I
V
QTR
LQT
P
EEF
GK
I
L
L
KVQQ
DG
SQ
V
L
L
R
DVA
R
VE
L
G
A
E
DYSTV
A
RY
NGK
-
P
A
A
G
IA
I
K
L
AT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAY
FP
A
S
L
K
TVYP
YDTT
PF
I
EI
SI
Q
E
VFKT
L
V
EAI
I
LV
F
LV
M
YLFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
A
I
L
S
A
V
G
F
T
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
D
KLP
P
KE
A
TH
K
SMG
QIQ
R
AL
VGIAVV
L
S
AVF
M
PM
A
F
MS
G
AT
G
E
IYR
Q
FSIT
LIS
S
M
LL
SV
F
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARF
N
TL
F
EKSTQH
----
Y
TDSTR
S
L
L
RCTGRY
M
V
VY
L
L
ICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
L
P
S
G
A
T
MVNTTKVLQ
Q
VT
DYY
LTKEKDN
V
Q
SVF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVT
AII
Q
RA
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AEL
G
TA
S
GFDME
L
LDNGNLGH
E
K
L
TQARN
E
L
LSL
A
AQS
P
DQ
V
TG
V
RP
N
G
LE
DTPMFK
VNV
N
AA
KA
E
A
M
GV
A
L
S
DI
NQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
ML
P
DN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
GS
PR
L
ERY
N
GI
P
SME
I
LG
EA
AAGK
S
T
G
D
A
MKFMADLVAK
L
-
-
P
A
G
VGYS
W
T
G
--
LS
YQ
EA
L
SSNQAPA
L
Y
A
-
I
S
L
V
V
VFL
A
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LS
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
VEMM
Q
KE
----------
G
KTPI
EA
IIE
A
ARM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
VI
S
H
GAGSG
AQNA
VG
T
GVMGGM
FA
A
T
V
LAI
Y
fig|331111.3.peg.1653
Escherichia coli E24377A (16-1018/1037)
AI
I
M
M
L
A
G
GLA
I
MN
LPV
A
QYP
Q
I
AP
P
T
I
T
V
S
A
T
YPGA
D
AQ
T
V
E
D
S
VT
Q
VIE
QN
M
NG
L
D
GLM
Y
MSS
T
S
DAA
G
NAS
ITL
T
FE
T
GT
S
PD
I
A
QV
QVQ
NK
LQ
L
A
MPS
LP
EAVQQQ
G
I
SVD-KSSSN
---
I
L
MVA
A
FI
S
DNGSLNQY
DI
A
D
Y
V
ASN
I
KDP
LS
RTA
GVG
S
V
QLF
G
SEY-AM
RI
W
LDP
QK
LN
KYN
L
VPSD
V
IS
Q
I
KVQ
N
NQISG
GQLGG
M
P
QAADQQLNAS
I
I
V
QTR
LQT
P
EEF
GK
I
L
L
KVQQ
DG
SQ
V
L
L
R
DVA
R
VE
L
G
A
E
DYSTV
A
RY
NGK
-
P
A
A
G
IA
I
K
L
AT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAY
FP
A
S
L
K
TVYP
YDTT
PF
I
EI
SI
Q
E
VFKT
L
V
EAI
I
LV
F
LV
M
YLFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
A
I
L
S
A
V
G
F
T
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
D
KLP
P
KE
A
TH
K
SMG
QIQ
R
AL
VGIAVV
L
S
AVF
M
PM
A
F
MS
G
AT
G
E
IYR
Q
FSIT
LIS
S
M
LL
SV
F
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARF
N
TL
F
EKSTQH
----
Y
TDSTR
S
L
L
RCTGRY
M
V
VY
L
L
ICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
L
P
S
G
A
T
MVNTTKVLQ
Q
VT
DYY
LTKEKDN
V
Q
SVF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVT
AII
Q
RA
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AEL
G
TA
S
GFDME
L
LDNGNLGH
E
K
L
TQARN
E
L
LSL
A
AQS
P
DQ
V
TG
V
RP
N
G
LE
DTPMFK
VNV
N
AA
KA
E
A
M
GV
A
L
S
DI
NQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
ML
P
DN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
GS
PR
L
ERY
N
GI
P
SME
I
LG
EA
AAGK
S
T
G
D
A
MKFMADLVAK
L
-
-
P
A
G
VGYS
W
T
G
--
LS
YQ
EA
L
SSNQAPA
L
Y
A
-
I
S
L
V
V
VFL
A
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LS
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
VEMM
Q
KE
----------
G
KTPI
EA
IIE
A
ARM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
VI
S
H
GAGSG
AQNA
VG
T
GVMGGM
FA
A
T
V
LAI
Y
fig|562.375.peg.4874
Escherichia coli EC4100B (16-1018/1037)
AI
I
M
M
L
A
G
GLA
I
MN
LPV
A
QYP
Q
I
AP
P
T
I
T
V
S
A
T
YPGA
D
AQ
T
V
E
D
S
VT
Q
VIE
QN
M
NG
L
D
GLM
Y
MSS
T
S
DAA
G
NAS
ITL
T
FE
T
GT
S
PD
I
A
QV
QVQ
NK
LQ
L
A
MPS
LP
EAVQQQ
G
I
SVD-KSSSN
---
I
L
MVA
A
FI
S
DNGSLNQY
DI
A
D
Y
V
ASN
I
KDP
LS
RTA
GVG
S
V
QLF
G
SEY-AM
RI
W
LDP
QK
LN
KYN
L
VPSD
V
IS
Q
I
KVQ
N
NQISG
GQLGG
M
P
QAADQQLNAS
I
I
V
QTR
LQT
P
EEF
GK
I
L
L
KVQQ
DG
SQ
V
L
L
R
DVA
R
VE
L
G
A
E
DYSTV
A
RY
NGK
-
P
A
A
G
IA
I
K
L
AT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAY
FP
A
S
L
K
TVYP
YDTT
PF
I
EI
SI
Q
E
VFKT
L
V
EAI
I
LV
F
LV
M
YLFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
A
I
L
S
A
V
G
F
T
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
D
KLP
P
KE
A
TH
K
SMG
QIQ
R
AL
VGIAVV
L
S
AVF
M
PM
A
F
MS
G
AT
G
E
IYR
Q
FSIT
LIS
S
M
LL
SV
F
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARF
N
TL
F
EKSTQH
----
Y
TDSTR
S
L
L
RCTGRY
M
V
VY
L
L
ICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
L
P
S
G
A
T
MVNTTKVLQ
Q
VT
DYY
LTKEKDN
V
Q
SVF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVT
AII
Q
RA
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AEL
G
TA
S
GFDME
L
LDNGNLGH
E
K
L
TQARN
E
L
LSL
A
AQS
P
DQ
V
TG
V
RP
N
G
LE
DTPMFK
VNV
N
AA
KA
E
A
M
GV
A
L
S
DI
NQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
ML
P
DN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
GS
PR
L
ERY
N
GI
P
SME
I
LG
EA
AAGK
S
T
G
D
A
MKFMADLVAK
L
-
-
P
A
G
VGYS
W
T
G
--
LS
YQ
EA
L
SSNQAPA
L
Y
A
-
I
S
L
V
V
VFL
A
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LS
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
VEMM
Q
KE
----------
G
KTPI
EA
IIE
A
ARM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
VI
S
H
GAGSG
AQNA
VG
T
GVMGGM
FA
A
T
V
LAI
Y
fig|656408.3.peg.3945
Escherichia coli H591 (16-1018/1037)
AI
I
M
M
L
A
G
GLA
I
MN
LPV
A
QYP
Q
I
AP
P
T
I
T
V
S
A
T
YPGA
D
AQ
T
V
E
D
S
VT
Q
VIE
QN
M
NG
L
D
GLM
Y
MSS
T
S
DAA
G
NAS
ITL
T
FE
T
GT
S
PD
I
A
QV
QVQ
NK
LQ
L
A
MPS
LP
EAVQQQ
G
I
SVD-KSSSN
---
I
L
MVA
A
FI
S
DNGSLNQY
DI
A
D
Y
V
ASN
I
KDP
LS
RTA
GVG
S
V
QLF
G
SEY-AM
RI
W
LDP
QK
LN
KYN
L
VPSD
V
IS
Q
I
KVQ
N
NQISG
GQLGG
M
P
QAADQQLNAS
I
I
V
QTR
LQT
P
EEF
GK
I
L
L
KVQQ
DG
SQ
V
L
L
R
DVA
R
VE
L
G
A
E
DYSTV
A
RY
NGK
-
P
A
A
G
IA
I
K
L
AT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAY
FP
A
S
L
K
TVYP
YDTT
PF
I
EI
SI
Q
E
VFKT
L
V
EAI
I
LV
F
LV
M
YLFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
A
I
L
S
A
V
G
F
T
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
D
KLP
P
KE
A
TH
K
SMG
QIQ
R
AL
VGIAVV
L
S
AVF
M
PM
A
F
MS
G
AT
G
E
IYR
Q
FSIT
LIS
S
M
LL
SV
F
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARF
N
TL
F
EKSTQH
----
Y
TDSTR
S
L
L
RCTGRY
M
V
VY
L
L
ICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
L
P
S
G
A
T
MVNTTKVLQ
Q
VT
DYY
LTKEKDN
V
Q
SVF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVT
AII
Q
RA
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AEL
G
TA
S
GFDME
L
LDNGNLGH
E
K
L
TQARN
E
L
LSL
A
AQS
P
DQ
V
TG
V
RP
N
G
LE
DTPMFK
VNV
N
AA
KA
E
A
M
GV
A
L
S
DI
NQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
ML
P
DN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
GS
PR
L
ERY
N
GI
P
SME
I
LG
EA
AAGK
S
T
G
D
A
MKFMADLVAK
L
-
-
P
A
G
VGYS
W
T
G
--
LS
YQ
EA
L
SSNQAPA
L
Y
A
-
I
S
L
V
V
VFL
A
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LS
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
VEMM
Q
KE
----------
G
KTPI
EA
IIE
A
ARM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
VI
S
H
GAGSG
AQNA
VG
T
GVMGGM
FA
A
T
V
LAI
Y
fig|595495.4.peg.1385
Escherichia coli KO11 (16-1018/1037)
AI
I
M
M
L
A
G
GLA
I
MN
LPV
A
QYP
Q
I
AP
P
T
I
T
V
S
A
T
YPGA
D
AQ
T
V
E
D
S
VT
Q
VIE
QN
M
NG
L
D
GLM
Y
MSS
T
S
DAA
G
NAS
ITL
T
FE
T
GT
S
PD
I
A
QV
QVQ
NK
LQ
L
A
MPS
LP
EAVQQQ
G
I
SVD-KSSSN
---
I
L
MVA
A
FI
S
DNGSLNQY
DI
A
D
Y
V
ASN
I
KDP
LS
RTA
GVG
S
V
QLF
G
SEY-AM
RI
W
LDP
QK
LN
KYN
L
VPSD
V
IS
Q
I
KVQ
N
NQISG
GQLGG
M
P
QAADQQLNAS
I
I
V
QTR
LQT
P
EEF
GK
I
L
L
KVQQ
DG
SQ
V
L
L
R
DVA
R
VE
L
G
A
E
DYSTV
A
RY
NGK
-
P
A
A
G
IA
I
K
L
AT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAY
FP
A
S
L
K
TVYP
YDTT
PF
I
EI
SI
Q
E
VFKT
L
V
EAI
I
LV
F
LV
M
YLFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
A
I
L
S
A
V
G
F
T
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
D
KLP
P
KE
A
TH
K
SMG
QIQ
R
AL
VGIAVV
L
S
AVF
M
PM
A
F
MS
G
AT
G
E
IYR
Q
FSIT
LIS
S
M
LL
SV
F
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARF
N
TL
F
EKSTQH
----
Y
TDSTR
S
L
L
RCTGRY
M
V
VY
L
L
ICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
L
P
S
G
A
T
MVNTTKVLQ
Q
VT
DYY
LTKEKDN
V
Q
SVF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVT
AII
Q
RA
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AEL
G
TA
S
GFDME
L
LDNGNLGH
E
K
L
TQARN
E
L
LSL
A
AQS
P
DQ
V
TG
V
RP
N
G
LE
DTPMFK
VNV
N
AA
KA
E
A
M
GV
A
L
S
DI
NQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
ML
P
DN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
GS
PR
L
ERY
N
GI
P
SME
I
LG
EA
AAGK
S
T
G
D
A
MKFMADLVAK
L
-
-
P
A
G
VGYS
W
T
G
--
LS
YQ
EA
L
SSNQAPA
L
Y
A
-
I
S
L
V
V
VFL
A
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LS
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
VEMM
Q
KE
----------
G
KTPI
EA
IIE
A
ARM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
VI
S
H
GAGSG
AQNA
VG
T
GVMGGM
FA
A
T
V
LAI
Y
fig|679207.4.peg.287
Escherichia coli MS 107-1 (16-1018/1037)
AI
I
M
M
L
A
G
GLA
I
MN
LPV
A
QYP
Q
I
AP
P
T
I
T
V
S
A
T
YPGA
D
AQ
T
V
E
D
S
VT
Q
VIE
QN
M
NG
L
D
GLM
Y
MSS
T
S
DAA
G
NAS
ITL
T
FE
T
GT
S
PD
I
A
QV
QVQ
NK
LQ
L
A
MPS
LP
EAVQQQ
G
I
SVD-KSSSN
---
I
L
MVA
A
FI
S
DNGSLNQY
DI
A
D
Y
V
ASN
I
KDP
LS
RTA
GVG
S
V
QLF
G
SEY-AM
RI
W
LDP
QK
LN
KYN
L
VPSD
V
IS
Q
I
KVQ
N
NQISG
GQLGG
M
P
QAADQQLNAS
I
I
V
QTR
LQT
P
EEF
GK
I
L
L
KVQQ
DG
SQ
V
L
L
R
DVA
R
VE
L
G
A
E
DYSTV
A
RY
NGK
-
P
A
A
G
IA
I
K
L
AT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAY
FP
A
S
L
K
TVYP
YDTT
PF
I
EI
SI
Q
E
VFKT
L
V
EAI
I
LV
F
LV
M
YLFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
A
I
L
S
A
V
G
F
T
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
D
KLP
P
KE
A
TH
K
SMG
QIQ
R
AL
VGIAVV
L
S
AVF
M
PM
A
F
MS
G
AT
G
E
IYR
Q
FSIT
LIS
S
M
LL
SV
F
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARF
N
TL
F
EKSTQH
----
Y
TDSTR
S
L
L
RCTGRY
M
V
VY
L
L
ICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
L
P
S
G
A
T
MVNTTKVLQ
Q
VT
DYY
LTKEKDN
V
Q
SVF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVT
AII
Q
RA
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AEL
G
TA
S
GFDME
L
LDNGNLGH
E
K
L
TQARN
E
L
LSL
A
AQS
P
DQ
V
TG
V
RP
N
G
LE
DTPMFK
VNV
N
AA
KA
E
A
M
GV
A
L
S
DI
NQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
ML
P
DN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
GS
PR
L
ERY
N
GI
P
SME
I
LG
EA
AAGK
S
T
G
D
A
MKFMADLVAK
L
-
-
P
A
G
VGYS
W
T
G
--
LS
YQ
EA
L
SSNQAPA
L
Y
A
-
I
S
L
V
V
VFL
A
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LS
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
VEMM
Q
KE
----------
G
KTPI
EA
IIE
A
ARM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
VI
S
H
GAGSG
AQNA
VG
T
GVMGGM
FA
A
T
V
LAI
Y
fig|679206.4.peg.1869
Escherichia coli MS 119-7 (16-1018/1037)
AI
I
M
M
L
A
G
GLA
I
MN
LPV
A
QYP
Q
I
AP
P
T
I
T
V
S
A
T
YPGA
D
AQ
T
V
E
D
S
VT
Q
VIE
QN
M
NG
L
D
GLM
Y
MSS
T
S
DAA
G
NAS
ITL
T
FE
T
GT
S
PD
I
A
QV
QVQ
NK
LQ
L
A
MPS
LP
EAVQQQ
G
I
SVD-KSSSN
---
I
L
MVA
A
FI
S
DNGSLNQY
DI
A
D
Y
V
ASN
I
KDP
LS
RTA
GVG
S
V
QLF
G
SEY-AM
RI
W
LDP
QK
LN
KYN
L
VPSD
V
IS
Q
I
KVQ
N
NQISG
GQLGG
M
P
QAADQQLNAS
I
I
V
QTR
LQT
P
EEF
GK
I
L
L
KVQQ
DG
SQ
V
L
L
R
DVA
R
VE
L
G
A
E
DYSTV
A
RY
NGK
-
P
A
A
G
IA
I
K
L
AT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAY
FP
A
S
L
K
TVYP
YDTT
PF
I
EI
SI
Q
E
VFKT
L
V
EAI
I
LV
F
LV
M
YLFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
A
I
L
S
A
V
G
F
T
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
D
KLP
P
KE
A
TH
K
SMG
QIQ
R
AL
VGIAVV
L
S
AVF
M
PM
A
F
MS
G
AT
G
E
IYR
Q
FSIT
LIS
S
M
LL
SV
F
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARF
N
TL
F
EKSTQH
----
Y
TDSTR
S
L
L
RCTGRY
M
V
VY
L
L
ICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
L
P
S
G
A
T
MVNTTKVLQ
Q
VT
DYY
LTKEKDN
V
Q
SVF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVT
AII
Q
RA
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AEL
G
TA
S
GFDME
L
LDNGNLGH
E
K
L
TQARN
E
L
LSL
A
AQS
P
DQ
V
TG
V
RP
N
G
LE
DTPMFK
VNV
N
AA
KA
E
A
M
GV
A
L
S
DI
NQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
ML
P
DN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
GS
PR
L
ERY
N
GI
P
SME
I
LG
EA
AAGK
S
T
G
D
A
MKFMADLVAK
L
-
-
P
A
G
VGYS
W
T
G
--
LS
YQ
EA
L
SSNQAPA
L
Y
A
-
I
S
L
V
V
VFL
A
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LS
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
VEMM
Q
KE
----------
G
KTPI
EA
IIE
A
ARM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
VI
S
H
GAGSG
AQNA
VG
T
GVMGGM
FA
A
T
V
LAI
Y
fig|749545.3.peg.4577
Escherichia coli MS 182-1 (16-1018/1037)
AI
I
M
M
L
A
G
GLA
I
MN
LPV
A
QYP
Q
I
AP
P
T
I
T
V
S
A
T
YPGA
D
AQ
T
V
E
D
S
VT
Q
VIE
QN
M
NG
L
D
GLM
Y
MSS
T
S
DAA
G
NAS
ITL
T
FE
T
GT
S
PD
I
A
QV
QVQ
NK
LQ
L
A
MPS
LP
EAVQQQ
G
I
SVD-KSSSN
---
I
L
MVA
A
FI
S
DNGSLNQY
DI
A
D
Y
V
ASN
I
KDP
LS
RTA
GVG
S
V
QLF
G
SEY-AM
RI
W
LDP
QK
LN
KYN
L
VPSD
V
IS
Q
I
KVQ
N
NQISG
GQLGG
M
P
QAADQQLNAS
I
I
V
QTR
LQT
P
EEF
GK
I
L
L
KVQQ
DG
SQ
V
L
L
R
DVA
R
VE
L
G
A
E
DYSTV
A
RY
NGK
-
P
A
A
G
IA
I
K
L
AT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAY
FP
A
S
L
K
TVYP
YDTT
PF
I
EI
SI
Q
E
VFKT
L
V
EAI
I
LV
F
LV
M
YLFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
A
I
L
S
A
V
G
F
T
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
D
KLP
P
KE
A
TH
K
SMG
QIQ
R
AL
VGIAVV
L
S
AVF
M
PM
A
F
MS
G
AT
G
E
IYR
Q
FSIT
LIS
S
M
LL
SV
F
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARF
N
TL
F
EKSTQH
----
Y
TDSTR
S
L
L
RCTGRY
M
V
VY
L
L
ICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
L
P
S
G
A
T
MVNTTKVLQ
Q
VT
DYY
LTKEKDN
V
Q
SVF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVT
AII
Q
RA
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AEL
G
TA
S
GFDME
L
LDNGNLGH
E
K
L
TQARN
E
L
LSL
A
AQS
P
DQ
V
TG
V
RP
N
G
LE
DTPMFK
VNV
N
AA
KA
E
A
M
GV
A
L
S
DI
NQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
ML
P
DN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
GS
PR
L
ERY
N
GI
P
SME
I
LG
EA
AAGK
S
T
G
D
A
MKFMADLVAK
L
-
-
P
A
G
VGYS
W
T
G
--
LS
YQ
EA
L
SSNQAPA
L
Y
A
-
I
S
L
V
V
VFL
A
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LS
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
VEMM
Q
KE
----------
G
KTPI
EA
IIE
A
ARM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
VI
S
H
GAGSG
AQNA
VG
T
GVMGGM
FA
A
T
V
LAI
Y
fig|749532.3.peg.3889
Escherichia coli MS 78-1 (16-1018/1037)
AI
I
M
M
L
A
G
GLA
I
MN
LPV
A
QYP
Q
I
AP
P
T
I
T
V
S
A
T
YPGA
D
AQ
T
V
E
D
S
VT
Q
VIE
QN
M
NG
L
D
GLM
Y
MSS
T
S
DAA
G
NAS
ITL
T
FE
T
GT
S
PD
I
A
QV
QVQ
NK
LQ
L
A
MPS
LP
EAVQQQ
G
I
SVD-KSSSN
---
I
L
MVA
A
FI
S
DNGSLNQY
DI
A
D
Y
V
ASN
I
KDP
LS
RTA
GVG
S
V
QLF
G
SEY-AM
RI
W
LDP
QK
LN
KYN
L
VPSD
V
IS
Q
I
KVQ
N
NQISG
GQLGG
M
P
QAADQQLNAS
I
I
V
QTR
LQT
P
EEF
GK
I
L
L
KVQQ
DG
SQ
V
L
L
R
DVA
R
VE
L
G
A
E
DYSTV
A
RY
NGK
-
P
A
A
G
IA
I
K
L
AT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAY
FP
A
S
L
K
TVYP
YDTT
PF
I
EI
SI
Q
E
VFKT
L
V
EAI
I
LV
F
LV
M
YLFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
A
I
L
S
A
V
G
F
T
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
D
KLP
P
KE
A
TH
K
SMG
QIQ
R
AL
VGIAVV
L
S
AVF
M
PM
A
F
MS
G
AT
G
E
IYR
Q
FSIT
LIS
S
M
LL
SV
F
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARF
N
TL
F
EKSTQH
----
Y
TDSTR
S
L
L
RCTGRY
M
V
VY
L
L
ICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
L
P
S
G
A
T
MVNTTKVLQ
Q
VT
DYY
LTKEKDN
V
Q
SVF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVT
AII
Q
RA
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AEL
G
TA
S
GFDME
L
LDNGNLGH
E
K
L
TQARN
E
L
LSL
A
AQS
P
DQ
V
TG
V
RP
N
G
LE
DTPMFK
VNV
N
AA
KA
E
A
M
GV
A
L
S
DI
NQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
ML
P
DN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
GS
PR
L
ERY
N
GI
P
SME
I
LG
EA
AAGK
S
T
G
D
A
MKFMADLVAK
L
-
-
P
A
G
VGYS
W
T
G
--
LS
YQ
EA
L
SSNQAPA
L
Y
A
-
I
S
L
V
V
VFL
A
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LS
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
VEMM
Q
KE
----------
G
KTPI
EA
IIE
A
ARM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
VI
S
H
GAGSG
AQNA
VG
T
GVMGGM
FA
A
T
V
LAI
Y
fig|585396.4.peg.4477
Escherichia coli O111:H- str. 11128 (16-1018/1037)
AI
I
M
M
L
A
G
GLA
I
MN
LPV
A
QYP
Q
I
AP
P
T
I
T
V
S
A
T
YPGA
D
AQ
T
V
E
D
S
VT
Q
VIE
QN
M
NG
L
D
GLM
Y
MSS
T
S
DAA
G
NAS
ITL
T
FE
T
GT
S
PD
I
A
QV
QVQ
NK
LQ
L
A
MPS
LP
EAVQQQ
G
I
SVD-KSSSN
---
I
L
MVA
A
FI
S
DNGSLNQY
DI
A
D
Y
V
ASN
I
KDP
LS
RTA
GVG
S
V
QLF
G
SEY-AM
RI
W
LDP
QK
LN
KYN
L
VPSD
V
IS
Q
I
KVQ
N
NQISG
GQLGG
M
P
QAADQQLNAS
I
I
V
QTR
LQT
P
EEF
GK
I
L
L
KVQQ
DG
SQ
V
L
L
R
DVA
R
VE
L
G
A
E
DYSTV
A
RY
NGK
-
P
A
A
G
IA
I
K
L
AT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAY
FP
A
S
L
K
TVYP
YDTT
PF
I
EI
SI
Q
E
VFKT
L
V
EAI
I
LV
F
LV
M
YLFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
A
I
L
S
A
V
G
F
T
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
D
KLP
P
KE
A
TH
K
SMG
QIQ
R
AL
VGIAVV
L
S
AVF
M
PM
A
F
MS
G
AT
G
E
IYR
Q
FSIT
LIS
S
M
LL
SV
F
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARF
N
TL
F
EKSTQH
----
Y
TDSTR
S
L
L
RCTGRY
M
V
VY
L
L
ICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
L
P
S
G
A
T
MVNTTKVLQ
Q
VT
DYY
LTKEKDN
V
Q
SVF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVT
AII
Q
RA
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AEL
G
TA
S
GFDME
L
LDNGNLGH
E
K
L
TQARN
E
L
LSL
A
AQS
P
DQ
V
TG
V
RP
N
G
LE
DTPMFK
VNV
N
AA
KA
E
A
M
GV
A
L
S
DI
NQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
ML
P
DN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
GS
PR
L
ERY
N
GI
P
SME
I
LG
EA
AAGK
S
T
G
D
A
MKFMADLVAK
L
-
-
P
A
G
VGYS
W
T
G
--
LS
YQ
EA
L
SSNQAPA
L
Y
A
-
I
S
L
V
V
VFL
A
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LS
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
VEMM
Q
KE
----------
G
KTPI
EA
IIE
A
ARM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
VI
S
H
GAGSG
AQNA
VG
T
GVMGGM
FA
A
T
V
LAI
Y
fig|409438.11.peg.3956
Escherichia coli SE11 (16-1018/1037)
AI
I
M
M
L
A
G
GLA
I
MN
LPV
A
QYP
Q
I
AP
P
T
I
T
V
S
A
T
YPGA
D
AQ
T
V
E
D
S
VT
Q
VIE
QN
M
NG
L
D
GLM
Y
MSS
T
S
DAA
G
NAS
ITL
T
FE
T
GT
S
PD
I
A
QV
QVQ
NK
LQ
L
A
MPS
LP
EAVQQQ
G
I
SVD-KSSSN
---
I
L
MVA
A
FI
S
DNGSLNQY
DI
A
D
Y
V
ASN
I
KDP
LS
RTA
GVG
S
V
QLF
G
SEY-AM
RI
W
LDP
QK
LN
KYN
L
VPSD
V
IS
Q
I
KVQ
N
NQISG
GQLGG
M
P
QAADQQLNAS
I
I
V
QTR
LQT
P
EEF
GK
I
L
L
KVQQ
DG
SQ
V
L
L
R
DVA
R
VE
L
G
A
E
DYSTV
A
RY
NGK
-
P
A
A
G
IA
I
K
L
AT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAY
FP
A
S
L
K
TVYP
YDTT
PF
I
EI
SI
Q
E
VFKT
L
V
EAI
I
LV
F
LV
M
YLFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
A
I
L
S
A
V
G
F
T
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
D
KLP
P
KE
A
TH
K
SMG
QIQ
R
AL
VGIAVV
L
S
AVF
M
PM
A
F
MS
G
AT
G
E
IYR
Q
FSIT
LIS
S
M
LL
SV
F
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARF
N
TL
F
EKSTQH
----
Y
TDSTR
S
L
L
RCTGRY
M
V
VY
L
L
ICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
L
P
S
G
A
T
MVNTTKVLQ
Q
VT
DYY
LTKEKDN
V
Q
SVF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVT
AII
Q
RA
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AEL
G
TA
S
GFDME
L
LDNGNLGH
E
K
L
TQARN
E
L
LSL
A
AQS
P
DQ
V
TG
V
RP
N
G
LE
DTPMFK
VNV
N
AA
KA
E
A
M
GV
A
L
S
DI
NQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
ML
P
DN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
GS
PR
L
ERY
N
GI
P
SME
I
LG
EA
AAGK
S
T
G
D
A
MKFMADLVAK
L
-
-
P
A
G
VGYS
W
T
G
--
LS
YQ
EA
L
SSNQAPA
L
Y
A
-
I
S
L
V
V
VFL
A
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LS
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
VEMM
Q
KE
----------
G
KTPI
EA
IIE
A
ARM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
VI
S
H
GAGSG
AQNA
VG
T
GVMGGM
FA
A
T
V
LAI
Y
fig|656443.3.peg.4425
Escherichia coli TA271 (16-1018/1037)
AI
I
M
M
L
A
G
GLA
I
MN
LPV
A
QYP
Q
I
AP
P
T
I
T
V
S
A
T
YPGA
D
AQ
T
V
E
D
S
VT
Q
VIE
QN
M
NG
L
D
GLM
Y
MSS
T
S
DAA
G
NAS
ITL
T
FE
T
GT
S
PD
I
A
QV
QVQ
NK
LQ
L
A
MPS
LP
EAVQQQ
G
I
SVD-KSSSN
---
I
L
MVA
A
FI
S
DNGSLNQY
DI
A
D
Y
V
ASN
I
KDP
LS
RTA
GVG
S
V
QLF
G
SEY-AM
RI
W
LDP
QK
LN
KYN
L
VPSD
V
IS
Q
I
KVQ
N
NQISG
GQLGG
M
P
QAADQQLNAS
I
I
V
QTR
LQT
P
EEF
GK
I
L
L
KVQQ
DG
SQ
V
L
L
R
DVA
R
VE
L
G
A
E
DYSTV
A
RY
NGK
-
P
A
A
G
IA
I
K
L
AT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAY
FP
A
S
L
K
TVYP
YDTT
PF
I
EI
SI
Q
E
VFKT
L
V
EAI
I
LV
F
LV
M
YLFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
A
I
L
S
A
V
G
F
T
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
D
KLP
P
KE
A
TH
K
SMG
QIQ
R
AL
VGIAVV
L
S
AVF
M
PM
A
F
MS
G
AT
G
E
IYR
Q
FSIT
LIS
S
M
LL
SV
F
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARF
N
TL
F
EKSTQH
----
Y
TDSTR
S
L
L
RCTGRY
M
V
VY
L
L
ICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
L
P
S
G
A
T
MVNTTKVLQ
Q
VT
DYY
LTKEKDN
V
Q
SVF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVT
AII
Q
RA
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AEL
G
TA
S
GFDME
L
LDNGNLGH
E
K
L
TQARN
E
L
LSL
A
AQS
P
DQ
V
TG
V
RP
N
G
LE
DTPMFK
VNV
N
AA
KA
E
A
M
GV
A
L
S
DI
NQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
ML
P
DN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
GS
PR
L
ERY
N
GI
P
SME
I
LG
EA
AAGK
S
T
G
D
A
MKFMADLVAK
L
-
-
P
A
G
VGYS
W
T
G
--
LS
YQ
EA
L
SSNQAPA
L
Y
A
-
I
S
L
V
V
VFL
A
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LS
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
VEMM
Q
KE
----------
G
KTPI
EA
IIE
A
ARM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
VI
S
H
GAGSG
AQNA
VG
T
GVMGGM
FA
A
T
V
LAI
Y
fig|566546.3.peg.1948
Escherichia coli W (16-1018/1037)
AI
I
M
M
L
A
G
GLA
I
MN
LPV
A
QYP
Q
I
AP
P
T
I
T
V
S
A
T
YPGA
D
AQ
T
V
E
D
S
VT
Q
VIE
QN
M
NG
L
D
GLM
Y
MSS
T
S
DAA
G
NAS
ITL
T
FE
T
GT
S
PD
I
A
QV
QVQ
NK
LQ
L
A
MPS
LP
EAVQQQ
G
I
SVD-KSSSN
---
I
L
MVA
A
FI
S
DNGSLNQY
DI
A
D
Y
V
ASN
I
KDP
LS
RTA
GVG
S
V
QLF
G
SEY-AM
RI
W
LDP
QK
LN
KYN
L
VPSD
V
IS
Q
I
KVQ
N
NQISG
GQLGG
M
P
QAADQQLNAS
I
I
V
QTR
LQT
P
EEF
GK
I
L
L
KVQQ
DG
SQ
V
L
L
R
DVA
R
VE
L
G
A
E
DYSTV
A
RY
NGK
-
P
A
A
G
IA
I
K
L
AT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAY
FP
A
S
L
K
TVYP
YDTT
PF
I
EI
SI
Q
E
VFKT
L
V
EAI
I
LV
F
LV
M
YLFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
A
I
L
S
A
V
G
F
T
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
D
KLP
P
KE
A
TH
K
SMG
QIQ
R
AL
VGIAVV
L
S
AVF
M
PM
A
F
MS
G
AT
G
E
IYR
Q
FSIT
LIS
S
M
LL
SV
F
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARF
N
TL
F
EKSTQH
----
Y
TDSTR
S
L
L
RCTGRY
M
V
VY
L
L
ICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
L
P
S
G
A
T
MVNTTKVLQ
Q
VT
DYY
LTKEKDN
V
Q
SVF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVT
AII
Q
RA
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AEL
G
TA
S
GFDME
L
LDNGNLGH
E
K
L
TQARN
E
L
LSL
A
AQS
P
DQ
V
TG
V
RP
N
G
LE
DTPMFK
VNV
N
AA
KA
E
A
M
GV
A
L
S
DI
NQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
ML
P
DN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
GS
PR
L
ERY
N
GI
P
SME
I
LG
EA
AAGK
S
T
G
D
A
MKFMADLVAK
L
-
-
P
A
G
VGYS
W
T
G
--
LS
YQ
EA
L
SSNQAPA
L
Y
A
-
I
S
L
V
V
VFL
A
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LS
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
VEMM
Q
KE
----------
G
KTPI
EA
IIE
A
ARM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
VI
S
H
GAGSG
AQNA
VG
T
GVMGGM
FA
A
T
V
LAI
Y
fig|566546.4.peg.3734
Escherichia coli W (16-1018/1037)
AI
I
M
M
L
A
G
GLA
I
MN
LPV
A
QYP
Q
I
AP
P
T
I
T
V
S
A
T
YPGA
D
AQ
T
V
E
D
S
VT
Q
VIE
QN
M
NG
L
D
GLM
Y
MSS
T
S
DAA
G
NAS
ITL
T
FE
T
GT
S
PD
I
A
QV
QVQ
NK
LQ
L
A
MPS
LP
EAVQQQ
G
I
SVD-KSSSN
---
I
L
MVA
A
FI
S
DNGSLNQY
DI
A
D
Y
V
ASN
I
KDP
LS
RTA
GVG
S
V
QLF
G
SEY-AM
RI
W
LDP
QK
LN
KYN
L
VPSD
V
IS
Q
I
KVQ
N
NQISG
GQLGG
M
P
QAADQQLNAS
I
I
V
QTR
LQT
P
EEF
GK
I
L
L
KVQQ
DG
SQ
V
L
L
R
DVA
R
VE
L
G
A
E
DYSTV
A
RY
NGK
-
P
A
A
G
IA
I
K
L
AT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAY
FP
A
S
L
K
TVYP
YDTT
PF
I
EI
SI
Q
E
VFKT
L
V
EAI
I
LV
F
LV
M
YLFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
A
I
L
S
A
V
G
F
T
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
D
KLP
P
KE
A
TH
K
SMG
QIQ
R
AL
VGIAVV
L
S
AVF
M
PM
A
F
MS
G
AT
G
E
IYR
Q
FSIT
LIS
S
M
LL
SV
F
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARF
N
TL
F
EKSTQH
----
Y
TDSTR
S
L
L
RCTGRY
M
V
VY
L
L
ICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
L
P
S
G
A
T
MVNTTKVLQ
Q
VT
DYY
LTKEKDN
V
Q
SVF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVT
AII
Q
RA
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AEL
G
TA
S
GFDME
L
LDNGNLGH
E
K
L
TQARN
E
L
LSL
A
AQS
P
DQ
V
TG
V
RP
N
G
LE
DTPMFK
VNV
N
AA
KA
E
A
M
GV
A
L
S
DI
NQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
ML
P
DN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
GS
PR
L
ERY
N
GI
P
SME
I
LG
EA
AAGK
S
T
G
D
A
MKFMADLVAK
L
-
-
P
A
G
VGYS
W
T
G
--
LS
YQ
EA
L
SSNQAPA
L
Y
A
-
I
S
L
V
V
VFL
A
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LS
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
VEMM
Q
KE
----------
G
KTPI
EA
IIE
A
ARM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
VI
S
H
GAGSG
AQNA
VG
T
GVMGGM
FA
A
T
V
LAI
Y
fig|562.371.peg.3299
Escherichia coli 1044A (16-1018/1037)
AI
I
M
M
L
A
G
GLA
I
MN
LPV
A
QYP
Q
I
AP
P
T
I
T
V
S
A
T
YPGA
D
AQ
T
V
E
D
S
VT
Q
VIE
QN
M
NG
L
D
GLM
Y
MSS
T
S
DAA
G
NAS
ITL
T
FE
T
GT
S
PD
I
A
QV
QVQ
NK
LQ
L
A
MPS
LP
EAVQQQ
G
I
SVD-KSSSN
---
I
L
MVA
A
FI
S
DNGSLNQY
DI
A
D
Y
V
ASN
I
KDP
LS
RTA
GVG
S
V
QLF
G
SEY-AM
RI
W
LDP
QK
LN
KYN
L
VPSD
V
IS
Q
I
KVQ
N
NQISG
GQLGG
M
P
QAADQQLNAS
I
I
V
QTR
LQT
P
EEF
GK
I
L
L
KVQQ
DG
SQ
V
L
L
R
DVA
R
VE
L
G
A
E
DYSTV
A
RY
NGK
-
P
A
A
G
IA
I
K
L
AT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAY
FP
A
S
L
K
TVYP
YDTT
PF
I
EI
SI
Q
E
VFKT
L
V
EAI
I
LV
F
LV
M
YLFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
A
I
L
S
A
V
G
F
T
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
D
KLP
P
KE
A
TH
K
SMG
QIQ
R
AL
VGIAVV
L
S
AVF
M
PM
A
F
MS
G
AT
G
E
IYR
Q
FSIT
LIS
S
M
LL
SV
F
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARF
N
TL
F
EKSTQH
----
Y
TDSTR
S
L
L
RCTGRY
M
V
I
Y
L
L
ICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
L
P
S
G
A
T
MVNTTKVLQ
Q
VT
DYY
LTKEKDN
V
Q
SVF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVT
AII
Q
RA
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AEL
G
TA
S
GFDME
L
LDNGNLGH
E
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
TG
V
RP
N
G
LE
DTPMFK
VNV
N
AA
KA
E
A
M
GV
A
L
S
DI
NQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
ML
P
DN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
GS
PR
L
ERY
N
GI
P
SME
I
LG
EA
AAGK
S
T
G
D
A
MKFMADLVAK
L
-
-
P
A
G
VGYS
W
T
G
--
LS
YQ
EA
L
SSNQAPA
L
Y
A
-
I
S
L
V
V
VFL
A
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LS
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
VEMM
Q
KE
----------
G
KTPI
EA
IIE
A
ARM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
VI
S
H
GAGSG
AQNA
VG
T
GVMGGM
FA
A
T
V
LAI
Y
fig|562.373.peg.1711
Escherichia coli 1125A (16-1018/1037)
AI
I
M
M
L
A
G
GLA
I
MN
LPV
A
QYP
Q
I
AP
P
T
I
T
V
S
A
T
YPGA
D
AQ
T
V
E
D
S
VT
Q
VIE
QN
M
NG
L
D
GLM
Y
MSS
T
S
DAA
G
NAS
ITL
T
FE
T
GT
S
PD
I
A
QV
QVQ
NK
LQ
L
A
MPS
LP
EAVQQQ
G
I
SVD-KSSSN
---
I
L
MVA
A
FI
S
DNGSLNQY
DI
A
D
Y
V
ASN
I
KDP
LS
RTA
GVG
S
V
QLF
G
SEY-AM
RI
W
LDP
QK
LN
KYN
L
VPSD
V
IS
Q
I
KVQ
N
NQISG
GQLGG
M
P
QAADQQLNAS
I
I
V
QTR
LQT
P
EEF
GK
I
L
L
KVQQ
DG
SQ
V
L
L
R
DVA
R
VE
L
G
A
E
DYSTV
A
RY
NGK
-
P
A
A
G
IA
I
K
L
AT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAY
FP
A
S
L
K
TVYP
YDTT
PF
I
EI
SI
Q
E
VFKT
L
V
EAI
I
LV
F
LV
M
YLFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
A
I
L
S
A
V
G
F
T
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
D
KLP
P
KE
A
TH
K
SMG
QIQ
R
AL
VGIAVV
L
S
AVF
M
PM
A
F
MS
G
AT
G
E
IYR
Q
FSIT
LIS
S
M
LL
SV
F
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARF
N
TL
F
EKSTQH
----
Y
TDSTR
S
L
L
RCTGRY
M
V
I
Y
L
L
ICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
L
P
S
G
A
T
MVNTTKVLQ
Q
VT
DYY
LTKEKDN
V
Q
SVF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVT
AII
Q
RA
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AEL
G
TA
S
GFDME
L
LDNGNLGH
E
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
TG
V
RP
N
G
LE
DTPMFK
VNV
N
AA
KA
E
A
M
GV
A
L
S
DI
NQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
ML
P
DN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
GS
PR
L
ERY
N
GI
P
SME
I
LG
EA
AAGK
S
T
G
D
A
MKFMADLVAK
L
-
-
P
A
G
VGYS
W
T
G
--
LS
YQ
EA
L
SSNQAPA
L
Y
A
-
I
S
L
V
V
VFL
A
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LS
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
VEMM
Q
KE
----------
G
KTPI
EA
IIE
A
ARM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
VI
S
H
GAGSG
AQNA
VG
T
GVMGGM
FA
A
T
V
LAI
Y
fig|562.372.peg.4181
Escherichia coli 1212A (16-1018/1037)
AI
I
M
M
L
A
G
GLA
I
MN
LPV
A
QYP
Q
I
AP
P
T
I
T
V
S
A
T
YPGA
D
AQ
T
V
E
D
S
VT
Q
VIE
QN
M
NG
L
D
GLM
Y
MSS
T
S
DAA
G
NAS
ITL
T
FE
T
GT
S
PD
I
A
QV
QVQ
NK
LQ
L
A
MPS
LP
EAVQQQ
G
I
SVD-KSSSN
---
I
L
MVA
A
FI
S
DNGSLNQY
DI
A
D
Y
V
ASN
I
KDP
LS
RTA
GVG
S
V
QLF
G
SEY-AM
RI
W
LDP
QK
LN
KYN
L
VPSD
V
IS
Q
I
KVQ
N
NQISG
GQLGG
M
P
QAADQQLNAS
I
I
V
QTR
LQT
P
EEF
GK
I
L
L
KVQQ
DG
SQ
V
L
L
R
DVA
R
VE
L
G
A
E
DYSTV
A
RY
NGK
-
P
A
A
G
IA
I
K
L
AT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAY
FP
A
S
L
K
TVYP
YDTT
PF
I
EI
SI
Q
E
VFKT
L
V
EAI
I
LV
F
LV
M
YLFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
A
I
L
S
A
V
G
F
T
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
D
KLP
P
KE
A
TH
K
SMG
QIQ
R
AL
VGIAVV
L
S
AVF
M
PM
A
F
MS
G
AT
G
E
IYR
Q
FSIT
LIS
S
M
LL
SV
F
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARF
N
TL
F
EKSTQH
----
Y
TDSTR
S
L
L
RCTGRY
M
V
I
Y
L
L
ICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
L
P
S
G
A
T
MVNTTKVLQ
Q
VT
DYY
LTKEKDN
V
Q
SVF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVT
AII
Q
RA
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AEL
G
TA
S
GFDME
L
LDNGNLGH
E
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
TG
V
RP
N
G
LE
DTPMFK
VNV
N
AA
KA
E
A
M
GV
A
L
S
DI
NQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
ML
P
DN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
GS
PR
L
ERY
N
GI
P
SME
I
LG
EA
AAGK
S
T
G
D
A
MKFMADLVAK
L
-
-
P
A
G
VGYS
W
T
G
--
LS
YQ
EA
L
SSNQAPA
L
Y
A
-
I
S
L
V
V
VFL
A
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LS
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
VEMM
Q
KE
----------
G
KTPI
EA
IIE
A
ARM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
VI
S
H
GAGSG
AQNA
VG
T
GVMGGM
FA
A
T
V
LAI
Y
fig|562.374.peg.5134
Escherichia coli 536A (16-1018/1037)
AI
I
M
M
L
A
G
GLA
I
MN
LPV
A
QYP
Q
I
AP
P
T
I
T
V
S
A
T
YPGA
D
AQ
T
V
E
D
S
VT
Q
VIE
QN
M
NG
L
D
GLM
Y
MSS
T
S
DAA
G
NAS
ITL
T
FE
T
GT
S
PD
I
A
QV
QVQ
NK
LQ
L
A
MPS
LP
EAVQQQ
G
I
SVD-KSSSN
---
I
L
MVA
A
FI
S
DNGSLNQY
DI
A
D
Y
V
ASN
I
KDP
LS
RTA
GVG
S
V
QLF
G
SEY-AM
RI
W
LDP
QK
LN
KYN
L
VPSD
V
IS
Q
I
KVQ
N
NQISG
GQLGG
M
P
QAADQQLNAS
I
I
V
QTR
LQT
P
EEF
GK
I
L
L
KVQQ
DG
SQ
V
L
L
R
DVA
R
VE
L
G
A
E
DYSTV
A
RY
NGK
-
P
A
A
G
IA
I
K
L
AT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAY
FP
A
S
L
K
TVYP
YDTT
PF
I
EI
SI
Q
E
VFKT
L
V
EAI
I
LV
F
LV
M
YLFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
A
I
L
S
A
V
G
F
T
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
D
KLP
P
KE
A
TH
K
SMG
QIQ
R
AL
VGIAVV
L
S
AVF
M
PM
A
F
MS
G
AT
G
E
IYR
Q
FSIT
LIS
S
M
LL
SV
F
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARF
N
TL
F
EKSTQH
----
Y
TDSTR
S
L
L
RCTGRY
M
V
I
Y
L
L
ICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
L
P
S
G
A
T
MVNTTKVLQ
Q
VT
DYY
LTKEKDN
V
Q
SVF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVT
AII
Q
RA
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AEL
G
TA
S
GFDME
L
LDNGNLGH
E
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
TG
V
RP
N
G
LE
DTPMFK
VNV
N
AA
KA
E
A
M
GV
A
L
S
DI
NQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
ML
P
DN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
GS
PR
L
ERY
N
GI
P
SME
I
LG
EA
AAGK
S
T
G
D
A
MKFMADLVAK
L
-
-
P
A
G
VGYS
W
T
G
--
LS
YQ
EA
L
SSNQAPA
L
Y
A
-
I
S
L
V
V
VFL
A
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LS
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
VEMM
Q
KE
----------
G
KTPI
EA
IIE
A
ARM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
VI
S
H
GAGSG
AQNA
VG
T
GVMGGM
FA
A
T
V
LAI
Y
fig|550676.3.peg.3693
Escherichia coli B185 (16-1018/1037)
AI
I
M
M
L
A
G
GLA
I
MN
LPV
A
QYP
Q
I
AP
P
T
I
T
V
S
A
T
YPGA
D
AQ
T
V
E
D
S
VT
Q
VIE
QN
M
NG
L
D
GLM
Y
MSS
T
S
DAA
G
NAS
ITL
T
FE
T
GT
S
PD
I
A
QV
QVQ
NK
LQ
L
A
MPS
LP
EAVQQQ
G
I
SVD-KSSSN
---
I
L
MVA
A
FI
S
DNGSLNQY
DI
A
D
Y
V
ASN
I
KDP
LS
RTA
GVG
S
V
QLF
G
SEY-AM
RI
W
LDP
QK
LN
KYN
L
VPSD
V
IS
Q
I
KVQ
N
NQISG
GQLGG
M
P
QAADQQLNAS
I
I
V
QTR
LQT
P
EEF
GK
I
L
L
KVQQ
DG
SQ
V
L
L
R
DVA
R
VE
L
G
A
E
DYSTV
A
RY
NGK
-
P
A
A
G
IA
I
K
L
AT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAY
FP
A
S
L
K
TVYP
YDTT
PF
I
EI
SI
Q
E
VFKT
L
V
EAI
I
LV
F
LV
M
YLFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
A
I
L
S
A
V
G
F
T
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
D
KLP
P
KE
A
TH
K
SMG
QIQ
R
AL
VGIAVV
L
S
AVF
M
PM
A
F
MS
G
AT
G
E
IYR
Q
FSIT
LIS
S
M
LL
SV
F
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARF
N
TL
F
EKSTQH
----
Y
TDSTR
S
L
L
RCTGRY
M
V
VY
L
L
ICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
L
P
S
G
A
T
MVNTTKVLQ
Q
VT
DYY
LTKEKDN
V
Q
SVF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVT
AII
Q
RA
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AEL
G
TA
S
GFDME
L
LDNGNLGH
E
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
TG
V
RP
N
G
LE
DTPMFK
VNV
N
AA
KA
E
A
M
GV
A
L
S
DI
NQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
ML
P
DN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
GS
PR
L
ERY
N
GI
P
SME
I
LG
EA
AAGK
S
T
G
D
A
MKFMADLVAK
L
-
-
P
A
G
VGYS
W
T
G
--
LS
YQ
EA
L
SSNQAPA
L
Y
A
-
I
S
L
V
V
VFL
A
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LS
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
VEMM
Q
KE
----------
G
KTPI
EA
IIE
A
ARM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
VI
S
H
GAGSG
AQNA
VG
T
GVMGGM
FA
A
T
V
LAI
Y
fig|83334.1.peg.4365
Escherichia coli O157:H7 (16-1018/1037)
AI
I
M
M
L
A
G
GLA
I
MN
LPV
A
QYP
Q
I
AP
P
T
I
T
V
S
A
T
YPGA
D
AQ
T
V
E
D
S
VT
Q
VIE
QN
M
NG
L
D
GLM
Y
MSS
T
S
DAA
G
NAS
ITL
T
FE
T
GT
S
PD
I
A
QV
QVQ
NK
LQ
L
A
MPS
LP
EAVQQQ
G
I
SVD-KSSSN
---
I
L
MVA
A
FI
S
DNGSLNQY
DI
A
D
Y
V
ASN
I
KDP
LS
RTA
GVG
S
V
QLF
G
SEY-AM
RI
W
LDP
QK
LN
KYN
L
VPSD
V
IS
Q
I
KVQ
N
NQISG
GQLGG
M
P
QAADQQLNAS
I
I
V
QTR
LQT
P
EEF
GK
I
L
L
KVQQ
DG
SQ
V
L
L
R
DVA
R
VE
L
G
A
E
DYSTV
A
RY
NGK
-
P
A
A
G
IA
I
K
L
AT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAY
FP
A
S
L
K
TVYP
YDTT
PF
I
EI
SI
Q
E
VFKT
L
V
EAI
I
LV
F
LV
M
YLFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
A
I
L
S
A
V
G
F
T
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
D
KLP
P
KE
A
TH
K
SMG
QIQ
R
AL
VGIAVV
L
S
AVF
M
PM
A
F
MS
G
AT
G
E
IYR
Q
FSIT
LIS
S
M
LL
SV
F
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARF
N
TL
F
EKSTQH
----
Y
TDSTR
S
L
L
RCTGRY
M
V
I
Y
L
L
ICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
L
P
S
G
A
T
MVNTTKVLQ
Q
VT
DYY
LTKEKDN
V
Q
SVF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVT
AII
Q
RA
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AEL
G
TA
S
GFDME
L
LDNGNLGH
E
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
TG
V
RP
N
G
LE
DTPMFK
VNV
N
AA
KA
E
A
M
GV
A
L
S
DI
NQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
ML
P
DN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
GS
PR
L
ERY
N
GI
P
SME
I
LG
EA
AAGK
S
T
G
D
A
MKFMADLVAK
L
-
-
P
A
G
VGYS
W
T
G
--
LS
YQ
EA
L
SSNQAPA
L
Y
A
-
I
S
L
V
V
VFL
A
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LS
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
VEMM
Q
KE
----------
G
KTPI
EA
IIE
A
ARM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
VI
S
H
GAGSG
AQNA
VG
T
GVMGGM
FA
A
T
V
LAI
Y
fig|444454.5.peg.3479
Escherichia coli O157:H7 str. EC4024 (16-1018/1037)
AI
I
M
M
L
A
G
GLA
I
MN
LPV
A
QYP
Q
I
AP
P
T
I
T
V
S
A
T
YPGA
D
AQ
T
V
E
D
S
VT
Q
VIE
QN
M
NG
L
D
GLM
Y
MSS
T
S
DAA
G
NAS
ITL
T
FE
T
GT
S
PD
I
A
QV
QVQ
NK
LQ
L
A
MPS
LP
EAVQQQ
G
I
SVD-KSSSN
---
I
L
MVA
A
FI
S
DNGSLNQY
DI
A
D
Y
V
ASN
I
KDP
LS
RTA
GVG
S
V
QLF
G
SEY-AM
RI
W
LDP
QK
LN
KYN
L
VPSD
V
IS
Q
I
KVQ
N
NQISG
GQLGG
M
P
QAADQQLNAS
I
I
V
QTR
LQT
P
EEF
GK
I
L
L
KVQQ
DG
SQ
V
L
L
R
DVA
R
VE
L
G
A
E
DYSTV
A
RY
NGK
-
P
A
A
G
IA
I
K
L
AT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAY
FP
A
S
L
K
TVYP
YDTT
PF
I
EI
SI
Q
E
VFKT
L
V
EAI
I
LV
F
LV
M
YLFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
A
I
L
S
A
V
G
F
T
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
D
KLP
P
KE
A
TH
K
SMG
QIQ
R
AL
VGIAVV
L
S
AVF
M
PM
A
F
MS
G
AT
G
E
IYR
Q
FSIT
LIS
S
M
LL
SV
F
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARF
N
TL
F
EKSTQH
----
Y
TDSTR
S
L
L
RCTGRY
M
V
I
Y
L
L
ICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
L
P
S
G
A
T
MVNTTKVLQ
Q
VT
DYY
LTKEKDN
V
Q
SVF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVT
AII
Q
RA
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AEL
G
TA
S
GFDME
L
LDNGNLGH
E
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
TG
V
RP
N
G
LE
DTPMFK
VNV
N
AA
KA
E
A
M
GV
A
L
S
DI
NQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
ML
P
DN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
GS
PR
L
ERY
N
GI
P
SME
I
LG
EA
AAGK
S
T
G
D
A
MKFMADLVAK
L
-
-
P
A
G
VGYS
W
T
G
--
LS
YQ
EA
L
SSNQAPA
L
Y
A
-
I
S
L
V
V
VFL
A
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LS
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
VEMM
Q
KE
----------
G
KTPI
EA
IIE
A
ARM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
VI
S
H
GAGSG
AQNA
VG
T
GVMGGM
FA
A
T
V
LAI
Y
fig|444449.5.peg.2933
Escherichia coli O157:H7 str. EC4042 (16-1018/1037)
AI
I
M
M
L
A
G
GLA
I
MN
LPV
A
QYP
Q
I
AP
P
T
I
T
V
S
A
T
YPGA
D
AQ
T
V
E
D
S
VT
Q
VIE
QN
M
NG
L
D
GLM
Y
MSS
T
S
DAA
G
NAS
ITL
T
FE
T
GT
S
PD
I
A
QV
QVQ
NK
LQ
L
A
MPS
LP
EAVQQQ
G
I
SVD-KSSSN
---
I
L
MVA
A
FI
S
DNGSLNQY
DI
A
D
Y
V
ASN
I
KDP
LS
RTA
GVG
S
V
QLF
G
SEY-AM
RI
W
LDP
QK
LN
KYN
L
VPSD
V
IS
Q
I
KVQ
N
NQISG
GQLGG
M
P
QAADQQLNAS
I
I
V
QTR
LQT
P
EEF
GK
I
L
L
KVQQ
DG
SQ
V
L
L
R
DVA
R
VE
L
G
A
E
DYSTV
A
RY
NGK
-
P
A
A
G
IA
I
K
L
AT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAY
FP
A
S
L
K
TVYP
YDTT
PF
I
EI
SI
Q
E
VFKT
L
V
EAI
I
LV
F
LV
M
YLFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
A
I
L
S
A
V
G
F
T
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
D
KLP
P
KE
A
TH
K
SMG
QIQ
R
AL
VGIAVV
L
S
AVF
M
PM
A
F
MS
G
AT
G
E
IYR
Q
FSIT
LIS
S
M
LL
SV
F
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARF
N
TL
F
EKSTQH
----
Y
TDSTR
S
L
L
RCTGRY
M
V
I
Y
L
L
ICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
L
P
S
G
A
T
MVNTTKVLQ
Q
VT
DYY
LTKEKDN
V
Q
SVF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVT
AII
Q
RA
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AEL
G
TA
S
GFDME
L
LDNGNLGH
E
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
TG
V
RP
N
G
LE
DTPMFK
VNV
N
AA
KA
E
A
M
GV
A
L
S
DI
NQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
ML
P
DN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
GS
PR
L
ERY
N
GI
P
SME
I
LG
EA
AAGK
S
T
G
D
A
MKFMADLVAK
L
-
-
P
A
G
VGYS
W
T
G
--
LS
YQ
EA
L
SSNQAPA
L
Y
A
-
I
S
L
V
V
VFL
A
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LS
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
VEMM
Q
KE
----------
G
KTPI
EA
IIE
A
ARM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
VI
S
H
GAGSG
AQNA
VG
T
GVMGGM
FA
A
T
V
LAI
Y
fig|444448.5.peg.1687
Escherichia coli O157:H7 str. EC4045 (16-1018/1037)
AI
I
M
M
L
A
G
GLA
I
MN
LPV
A
QYP
Q
I
AP
P
T
I
T
V
S
A
T
YPGA
D
AQ
T
V
E
D
S
VT
Q
VIE
QN
M
NG
L
D
GLM
Y
MSS
T
S
DAA
G
NAS
ITL
T
FE
T
GT
S
PD
I
A
QV
QVQ
NK
LQ
L
A
MPS
LP
EAVQQQ
G
I
SVD-KSSSN
---
I
L
MVA
A
FI
S
DNGSLNQY
DI
A
D
Y
V
ASN
I
KDP
LS
RTA
GVG
S
V
QLF
G
SEY-AM
RI
W
LDP
QK
LN
KYN
L
VPSD
V
IS
Q
I
KVQ
N
NQISG
GQLGG
M
P
QAADQQLNAS
I
I
V
QTR
LQT
P
EEF
GK
I
L
L
KVQQ
DG
SQ
V
L
L
R
DVA
R
VE
L
G
A
E
DYSTV
A
RY
NGK
-
P
A
A
G
IA
I
K
L
AT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAY
FP
A
S
L
K
TVYP
YDTT
PF
I
EI
SI
Q
E
VFKT
L
V
EAI
I
LV
F
LV
M
YLFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
A
I
L
S
A
V
G
F
T
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
D
KLP
P
KE
A
TH
K
SMG
QIQ
R
AL
VGIAVV
L
S
AVF
M
PM
A
F
MS
G
AT
G
E
IYR
Q
FSIT
LIS
S
M
LL
SV
F
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARF
N
TL
F
EKSTQH
----
Y
TDSTR
S
L
L
RCTGRY
M
V
I
Y
L
L
ICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
L
P
S
G
A
T
MVNTTKVLQ
Q
VT
DYY
LTKEKDN
V
Q
SVF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVT
AII
Q
RA
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AEL
G
TA
S
GFDME
L
LDNGNLGH
E
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
TG
V
RP
N
G
LE
DTPMFK
VNV
N
AA
KA
E
A
M
GV
A
L
S
DI
NQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
ML
P
DN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
GS
PR
L
ERY
N
GI
P
SME
I
LG
EA
AAGK
S
T
G
D
A
MKFMADLVAK
L
-
-
P
A
G
VGYS
W
T
G
--
LS
YQ
EA
L
SSNQAPA
L
Y
A
-
I
S
L
V
V
VFL
A
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LS
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
VEMM
Q
KE
----------
G
KTPI
EA
IIE
A
ARM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
VI
S
H
GAGSG
AQNA
VG
T
GVMGGM
FA
A
T
V
LAI
Y
fig|444453.5.peg.1218
Escherichia coli O157:H7 str. EC4076 (16-1018/1037)
AI
I
M
M
L
A
G
GLA
I
MN
LPV
A
QYP
Q
I
AP
P
T
I
T
V
S
A
T
YPGA
D
AQ
T
V
E
D
S
VT
Q
VIE
QN
M
NG
L
D
GLM
Y
MSS
T
S
DAA
G
NAS
ITL
T
FE
T
GT
S
PD
I
A
QV
QVQ
NK
LQ
L
A
MPS
LP
EAVQQQ
G
I
SVD-KSSSN
---
I
L
MVA
A
FI
S
DNGSLNQY
DI
A
D
Y
V
ASN
I
KDP
LS
RTA
GVG
S
V
QLF
G
SEY-AM
RI
W
LDP
QK
LN
KYN
L
VPSD
V
IS
Q
I
KVQ
N
NQISG
GQLGG
M
P
QAADQQLNAS
I
I
V
QTR
LQT
P
EEF
GK
I
L
L
KVQQ
DG
SQ
V
L
L
R
DVA
R
VE
L
G
A
E
DYSTV
A
RY
NGK
-
P
A
A
G
IA
I
K
L
AT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAY
FP
A
S
L
K
TVYP
YDTT
PF
I
EI
SI
Q
E
VFKT
L
V
EAI
I
LV
F
LV
M
YLFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
A
I
L
S
A
V
G
F
T
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
D
KLP
P
KE
A
TH
K
SMG
QIQ
R
AL
VGIAVV
L
S
AVF
M
PM
A
F
MS
G
AT
G
E
IYR
Q
FSIT
LIS
S
M
LL
SV
F
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARF
N
TL
F
EKSTQH
----
Y
TDSTR
S
L
L
RCTGRY
M
V
I
Y
L
L
ICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
L
P
S
G
A
T
MVNTTKVLQ
Q
VT
DYY
LTKEKDN
V
Q
SVF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVT
AII
Q
RA
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AEL
G
TA
S
GFDME
L
LDNGNLGH
E
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
TG
V
RP
N
G
LE
DTPMFK
VNV
N
AA
KA
E
A
M
GV
A
L
S
DI
NQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
ML
P
DN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
GS
PR
L
ERY
N
GI
P
SME
I
LG
EA
AAGK
S
T
G
D
A
MKFMADLVAK
L
-
-
P
A
G
VGYS
W
T
G
--
LS
YQ
EA
L
SSNQAPA
L
Y
A
-
I
S
L
V
V
VFL
A
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LS
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
VEMM
Q
KE
----------
G
KTPI
EA
IIE
A
ARM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
VI
S
H
GAGSG
AQNA
VG
T
GVMGGM
FA
A
T
V
LAI
Y
fig|444452.5.peg.124
Escherichia coli O157:H7 str. EC4113 (16-1018/1037)
AI
I
M
M
L
A
G
GLA
I
MN
LPV
A
QYP
Q
I
AP
P
T
I
T
V
S
A
T
YPGA
D
AQ
T
V
E
D
S
VT
Q
VIE
QN
M
NG
L
D
GLM
Y
MSS
T
S
DAA
G
NAS
ITL
T
FE
T
GT
S
PD
I
A
QV
QVQ
NK
LQ
L
A
MPS
LP
EAVQQQ
G
I
SVD-KSSSN
---
I
L
MVA
A
FI
S
DNGSLNQY
DI
A
D
Y
V
ASN
I
KDP
LS
RTA
GVG
S
V
QLF
G
SEY-AM
RI
W
LDP
QK
LN
KYN
L
VPSD
V
IS
Q
I
KVQ
N
NQISG
GQLGG
M
P
QAADQQLNAS
I
I
V
QTR
LQT
P
EEF
GK
I
L
L
KVQQ
DG
SQ
V
L
L
R
DVA
R
VE
L
G
A
E
DYSTV
A
RY
NGK
-
P
A
A
G
IA
I
K
L
AT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAY
FP
A
S
L
K
TVYP
YDTT
PF
I
EI
SI
Q
E
VFKT
L
V
EAI
I
LV
F
LV
M
YLFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
A
I
L
S
A
V
G
F
T
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
D
KLP
P
KE
A
TH
K
SMG
QIQ
R
AL
VGIAVV
L
S
AVF
M
PM
A
F
MS
G
AT
G
E
IYR
Q
FSIT
LIS
S
M
LL
SV
F
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARF
N
TL
F
EKSTQH
----
Y
TDSTR
S
L
L
RCTGRY
M
V
I
Y
L
L
ICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
L
P
S
G
A
T
MVNTTKVLQ
Q
VT
DYY
LTKEKDN
V
Q
SVF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVT
AII
Q
RA
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AEL
G
TA
S
GFDME
L
LDNGNLGH
E
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
TG
V
RP
N
G
LE
DTPMFK
VNV
N
AA
KA
E
A
M
GV
A
L
S
DI
NQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
ML
P
DN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
GS
PR
L
ERY
N
GI
P
SME
I
LG
EA
AAGK
S
T
G
D
A
MKFMADLVAK
L
-
-
P
A
G
VGYS
W
T
G
--
LS
YQ
EA
L
SSNQAPA
L
Y
A
-
I
S
L
V
V
VFL
A
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LS
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
VEMM
Q
KE
----------
G
KTPI
EA
IIE
A
ARM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
VI
S
H
GAGSG
AQNA
VG
T
GVMGGM
FA
A
T
V
LAI
Y
fig|444450.8.peg.4768
Escherichia coli O157:H7 str. EC4115 (16-1018/1037)
AI
I
M
M
L
A
G
GLA
I
MN
LPV
A
QYP
Q
I
AP
P
T
I
T
V
S
A
T
YPGA
D
AQ
T
V
E
D
S
VT
Q
VIE
QN
M
NG
L
D
GLM
Y
MSS
T
S
DAA
G
NAS
ITL
T
FE
T
GT
S
PD
I
A
QV
QVQ
NK
LQ
L
A
MPS
LP
EAVQQQ
G
I
SVD-KSSSN
---
I
L
MVA
A
FI
S
DNGSLNQY
DI
A
D
Y
V
ASN
I
KDP
LS
RTA
GVG
S
V
QLF
G
SEY-AM
RI
W
LDP
QK
LN
KYN
L
VPSD
V
IS
Q
I
KVQ
N
NQISG
GQLGG
M
P
QAADQQLNAS
I
I
V
QTR
LQT
P
EEF
GK
I
L
L
KVQQ
DG
SQ
V
L
L
R
DVA
R
VE
L
G
A
E
DYSTV
A
RY
NGK
-
P
A
A
G
IA
I
K
L
AT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAY
FP
A
S
L
K
TVYP
YDTT
PF
I
EI
SI
Q
E
VFKT
L
V
EAI
I
LV
F
LV
M
YLFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
A
I
L
S
A
V
G
F
T
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
D
KLP
P
KE
A
TH
K
SMG
QIQ
R
AL
VGIAVV
L
S
AVF
M
PM
A
F
MS
G
AT
G
E
IYR
Q
FSIT
LIS
S
M
LL
SV
F
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARF
N
TL
F
EKSTQH
----
Y
TDSTR
S
L
L
RCTGRY
M
V
I
Y
L
L
ICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
L
P
S
G
A
T
MVNTTKVLQ
Q
VT
DYY
LTKEKDN
V
Q
SVF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVT
AII
Q
RA
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AEL
G
TA
S
GFDME
L
LDNGNLGH
E
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
TG
V
RP
N
G
LE
DTPMFK
VNV
N
AA
KA
E
A
M
GV
A
L
S
DI
NQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
ML
P
DN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
GS
PR
L
ERY
N
GI
P
SME
I
LG
EA
AAGK
S
T
G
D
A
MKFMADLVAK
L
-
-
P
A
G
VGYS
W
T
G
--
LS
YQ
EA
L
SSNQAPA
L
Y
A
-
I
S
L
V
V
VFL
A
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LS
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
VEMM
Q
KE
----------
G
KTPI
EA
IIE
A
ARM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
VI
S
H
GAGSG
AQNA
VG
T
GVMGGM
FA
A
T
V
LAI
Y
fig|444451.5.peg.298
Escherichia coli O157:H7 str. EC4196 (16-1018/1037)
AI
I
M
M
L
A
G
GLA
I
MN
LPV
A
QYP
Q
I
AP
P
T
I
T
V
S
A
T
YPGA
D
AQ
T
V
E
D
S
VT
Q
VIE
QN
M
NG
L
D
GLM
Y
MSS
T
S
DAA
G
NAS
ITL
T
FE
T
GT
S
PD
I
A
QV
QVQ
NK
LQ
L
A
MPS
LP
EAVQQQ
G
I
SVD-KSSSN
---
I
L
MVA
A
FI
S
DNGSLNQY
DI
A
D
Y
V
ASN
I
KDP
LS
RTA
GVG
S
V
QLF
G
SEY-AM
RI
W
LDP
QK
LN
KYN
L
VPSD
V
IS
Q
I
KVQ
N
NQISG
GQLGG
M
P
QAADQQLNAS
I
I
V
QTR
LQT
P
EEF
GK
I
L
L
KVQQ
DG
SQ
V
L
L
R
DVA
R
VE
L
G
A
E
DYSTV
A
RY
NGK
-
P
A
A
G
IA
I
K
L
AT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAY
FP
A
S
L
K
TVYP
YDTT
PF
I
EI
SI
Q
E
VFKT
L
V
EAI
I
LV
F
LV
M
YLFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
A
I
L
S
A
V
G
F
T
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
D
KLP
P
KE
A
TH
K
SMG
QIQ
R
AL
VGIAVV
L
S
AVF
M
PM
A
F
MS
G
AT
G
E
IYR
Q
FSIT
LIS
S
M
LL
SV
F
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARF
N
TL
F
EKSTQH
----
Y
TDSTR
S
L
L
RCTGRY
M
V
I
Y
L
L
ICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
L
P
S
G
A
T
MVNTTKVLQ
Q
VT
DYY
LTKEKDN
V
Q
SVF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVT
AII
Q
RA
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AEL
G
TA
S
GFDME
L
LDNGNLGH
E
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
TG
V
RP
N
G
LE
DTPMFK
VNV
N
AA
KA
E
A
M
GV
A
L
S
DI
NQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
ML
P
DN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
GS
PR
L
ERY
N
GI
P
SME
I
LG
EA
AAGK
S
T
G
D
A
MKFMADLVAK
L
-
-
P
A
G
VGYS
W
T
G
--
LS
YQ
EA
L
SSNQAPA
L
Y
A
-
I
S
L
V
V
VFL
A
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LS
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
VEMM
Q
KE
----------
G
KTPI
EA
IIE
A
ARM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
VI
S
H
GAGSG
AQNA
VG
T
GVMGGM
FA
A
T
V
LAI
Y
fig|444447.5.peg.1850
Escherichia coli O157:H7 str. EC4206 (16-1018/1037)
AI
I
M
M
L
A
G
GLA
I
MN
LPV
A
QYP
Q
I
AP
P
T
I
T
V
S
A
T
YPGA
D
AQ
T
V
E
D
S
VT
Q
VIE
QN
M
NG
L
D
GLM
Y
MSS
T
S
DAA
G
NAS
ITL
T
FE
T
GT
S
PD
I
A
QV
QVQ
NK
LQ
L
A
MPS
LP
EAVQQQ
G
I
SVD-KSSSN
---
I
L
MVA
A
FI
S
DNGSLNQY
DI
A
D
Y
V
ASN
I
KDP
LS
RTA
GVG
S
V
QLF
G
SEY-AM
RI
W
LDP
QK
LN
KYN
L
VPSD
V
IS
Q
I
KVQ
N
NQISG
GQLGG
M
P
QAADQQLNAS
I
I
V
QTR
LQT
P
EEF
GK
I
L
L
KVQQ
DG
SQ
V
L
L
R
DVA
R
VE
L
G
A
E
DYSTV
A
RY
NGK
-
P
A
A
G
IA
I
K
L
AT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAY
FP
A
S
L
K
TVYP
YDTT
PF
I
EI
SI
Q
E
VFKT
L
V
EAI
I
LV
F
LV
M
YLFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
A
I
L
S
A
V
G
F
T
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
D
KLP
P
KE
A
TH
K
SMG
QIQ
R
AL
VGIAVV
L
S
AVF
M
PM
A
F
MS
G
AT
G
E
IYR
Q
FSIT
LIS
S
M
LL
SV
F
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARF
N
TL
F
EKSTQH
----
Y
TDSTR
S
L
L
RCTGRY
M
V
I
Y
L
L
ICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
L
P
S
G
A
T
MVNTTKVLQ
Q
VT
DYY
LTKEKDN
V
Q
SVF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVT
AII
Q
RA
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AEL
G
TA
S
GFDME
L
LDNGNLGH
E
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
TG
V
RP
N
G
LE
DTPMFK
VNV
N
AA
KA
E
A
M
GV
A
L
S
DI
NQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
ML
P
DN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
GS
PR
L
ERY
N
GI
P
SME
I
LG
EA
AAGK
S
T
G
D
A
MKFMADLVAK
L
-
-
P
A
G
VGYS
W
T
G
--
LS
YQ
EA
L
SSNQAPA
L
Y
A
-
I
S
L
V
V
VFL
A
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LS
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
VEMM
Q
KE
----------
G
KTPI
EA
IIE
A
ARM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
VI
S
H
GAGSG
AQNA
VG
T
GVMGGM
FA
A
T
V
LAI
Y
fig|478004.5.peg.244
Escherichia coli O157:H7 str. EC4401 (16-1018/1037)
AI
I
M
M
L
A
G
GLA
I
MN
LPV
A
QYP
Q
I
AP
P
T
I
T
V
S
A
T
YPGA
D
AQ
T
V
E
D
S
VT
Q
VIE
QN
M
NG
L
D
GLM
Y
MSS
T
S
DAA
G
NAS
ITL
T
FE
T
GT
S
PD
I
A
QV
QVQ
NK
LQ
L
A
MPS
LP
EAVQQQ
G
I
SVD-KSSSN
---
I
L
MVA
A
FI
S
DNGSLNQY
DI
A
D
Y
V
ASN
I
KDP
LS
RTA
GVG
S
V
QLF
G
SEY-AM
RI
W
LDP
QK
LN
KYN
L
VPSD
V
IS
Q
I
KVQ
N
NQISG
GQLGG
M
P
QAADQQLNAS
I
I
V
QTR
LQT
P
EEF
GK
I
L
L
KVQQ
DG
SQ
V
L
L
R
DVA
R
VE
L
G
A
E
DYSTV
A
RY
NGK
-
P
A
A
G
IA
I
K
L
AT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAY
FP
A
S
L
K
TVYP
YDTT
PF
I
EI
SI
Q
E
VFKT
L
V
EAI
I
LV
F
LV
M
YLFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
A
I
L
S
A
V
G
F
T
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
D
KLP
P
KE
A
TH
K
SMG
QIQ
R
AL
VGIAVV
L
S
AVF
M
PM
A
F
MS
G
AT
G
E
IYR
Q
FSIT
LIS
S
M
LL
SV
F
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARF
N
TL
F
EKSTQH
----
Y
TDSTR
S
L
L
RCTGRY
M
V
I
Y
L
L
ICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
L
P
S
G
A
T
MVNTTKVLQ
Q
VT
DYY
LTKEKDN
V
Q
SVF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVT
AII
Q
RA
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AEL
G
TA
S
GFDME
L
LDNGNLGH
E
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
TG
V
RP
N
G
LE
DTPMFK
VNV
N
AA
KA
E
A
M
GV
A
L
S
DI
NQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
ML
P
DN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
GS
PR
L
ERY
N
GI
P
SME
I
LG
EA
AAGK
S
T
G
D
A
MKFMADLVAK
L
-
-
P
A
G
VGYS
W
T
G
--
LS
YQ
EA
L
SSNQAPA
L
Y
A
-
I
S
L
V
V
VFL
A
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LS
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
VEMM
Q
KE
----------
G
KTPI
EA
IIE
A
ARM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
VI
S
H
GAGSG
AQNA
VG
T
GVMGGM
FA
A
T
V
LAI
Y
fig|478005.5.peg.201
Escherichia coli O157:H7 str. EC4486 (16-1018/1037)
AI
I
M
M
L
A
G
GLA
I
MN
LPV
A
QYP
Q
I
AP
P
T
I
T
V
S
A
T
YPGA
D
AQ
T
V
E
D
S
VT
Q
VIE
QN
M
NG
L
D
GLM
Y
MSS
T
S
DAA
G
NAS
ITL
T
FE
T
GT
S
PD
I
A
QV
QVQ
NK
LQ
L
A
MPS
LP
EAVQQQ
G
I
SVD-KSSSN
---
I
L
MVA
A
FI
S
DNGSLNQY
DI
A
D
Y
V
ASN
I
KDP
LS
RTA
GVG
S
V
QLF
G
SEY-AM
RI
W
LDP
QK
LN
KYN
L
VPSD
V
IS
Q
I
KVQ
N
NQISG
GQLGG
M
P
QAADQQLNAS
I
I
V
QTR
LQT
P
EEF
GK
I
L
L
KVQQ
DG
SQ
V
L
L
R
DVA
R
VE
L
G
A
E
DYSTV
A
RY
NGK
-
P
A
A
G
IA
I
K
L
AT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAY
FP
A
S
L
K
TVYP
YDTT
PF
I
EI
SI
Q
E
VFKT
L
V
EAI
I
LV
F
LV
M
YLFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
A
I
L
S
A
V
G
F
T
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
D
KLP
P
KE
A
TH
K
SMG
QIQ
R
AL
VGIAVV
L
S
AVF
M
PM
A
F
MS
G
AT
G
E
IYR
Q
FSIT
LIS
S
M
LL
SV
F
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARF
N
TL
F
EKSTQH
----
Y
TDSTR
S
L
L
RCTGRY
M
V
I
Y
L
L
ICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
L
P
S
G
A
T
MVNTTKVLQ
Q
VT
DYY
LTKEKDN
V
Q
SVF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVT
AII
Q
RA
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AEL
G
TA
S
GFDME
L
LDNGNLGH
E
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
TG
V
RP
N
G
LE
DTPMFK
VNV
N
AA
KA
E
A
M
GV
A
L
S
DI
NQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
ML
P
DN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
GS
PR
L
ERY
N
GI
P
SME
I
LG
EA
AAGK
S
T
G
D
A
MKFMADLVAK
L
-
-
P
A
G
VGYS
W
T
G
--
LS
YQ
EA
L
SSNQAPA
L
Y
A
-
I
S
L
V
V
VFL
A
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LS
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
VEMM
Q
KE
----------
G
KTPI
EA
IIE
A
ARM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
VI
S
H
GAGSG
AQNA
VG
T
GVMGGM
FA
A
T
V
LAI
Y
fig|478006.5.peg.209
Escherichia coli O157:H7 str. EC4501 (16-1018/1037)
AI
I
M
M
L
A
G
GLA
I
MN
LPV
A
QYP
Q
I
AP
P
T
I
T
V
S
A
T
YPGA
D
AQ
T
V
E
D
S
VT
Q
VIE
QN
M
NG
L
D
GLM
Y
MSS
T
S
DAA
G
NAS
ITL
T
FE
T
GT
S
PD
I
A
QV
QVQ
NK
LQ
L
A
MPS
LP
EAVQQQ
G
I
SVD-KSSSN
---
I
L
MVA
A
FI
S
DNGSLNQY
DI
A
D
Y
V
ASN
I
KDP
LS
RTA
GVG
S
V
QLF
G
SEY-AM
RI
W
LDP
QK
LN
KYN
L
VPSD
V
IS
Q
I
KVQ
N
NQISG
GQLGG
M
P
QAADQQLNAS
I
I
V
QTR
LQT
P
EEF
GK
I
L
L
KVQQ
DG
SQ
V
L
L
R
DVA
R
VE
L
G
A
E
DYSTV
A
RY
NGK
-
P
A
A
G
IA
I
K
L
AT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAY
FP
A
S
L
K
TVYP
YDTT
PF
I
EI
SI
Q
E
VFKT
L
V
EAI
I
LV
F
LV
M
YLFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
A
I
L
S
A
V
G
F
T
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
D
KLP
P
KE
A
TH
K
SMG
QIQ
R
AL
VGIAVV
L
S
AVF
M
PM
A
F
MS
G
AT
G
E
IYR
Q
FSIT
LIS
S
M
LL
SV
F
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARF
N
TL
F
EKSTQH
----
Y
TDSTR
S
L
L
RCTGRY
M
V
I
Y
L
L
ICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
L
P
S
G
A
T
MVNTTKVLQ
Q
VT
DYY
LTKEKDN
V
Q
SVF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVT
AII
Q
RA
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AEL
G
TA
S
GFDME
L
LDNGNLGH
E
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
TG
V
RP
N
G
LE
DTPMFK
VNV
N
AA
KA
E
A
M
GV
A
L
S
DI
NQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
ML
P
DN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
GS
PR
L
ERY
N
GI
P
SME
I
LG
EA
AAGK
S
T
G
D
A
MKFMADLVAK
L
-
-
P
A
G
VGYS
W
T
G
--
LS
YQ
EA
L
SSNQAPA
L
Y
A
-
I
S
L
V
V
VFL
A
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LS
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
VEMM
Q
KE
----------
G
KTPI
EA
IIE
A
ARM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
VI
S
H
GAGSG
AQNA
VG
T
GVMGGM
FA
A
T
V
LAI
Y
fig|478007.5.peg.217
Escherichia coli O157:H7 str. EC508 (16-1018/1037)
AI
I
M
M
L
A
G
GLA
I
MN
LPV
A
QYP
Q
I
AP
P
T
I
T
V
S
A
T
YPGA
D
AQ
T
V
E
D
S
VT
Q
VIE
QN
M
NG
L
D
GLM
Y
MSS
T
S
DAA
G
NAS
ITL
T
FE
T
GT
S
PD
I
A
QV
QVQ
NK
LQ
L
A
MPS
LP
EAVQQQ
G
I
SVD-KSSSN
---
I
L
MVA
A
FI
S
DNGSLNQY
DI
A
D
Y
V
ASN
I
KDP
LS
RTA
GVG
S
V
QLF
G
SEY-AM
RI
W
LDP
QK
LN
KYN
L
VPSD
V
IS
Q
I
KVQ
N
NQISG
GQLGG
M
P
QAADQQLNAS
I
I
V
QTR
LQT
P
EEF
GK
I
L
L
KVQQ
DG
SQ
V
L
L
R
DVA
R
VE
L
G
A
E
DYSTV
A
RY
NGK
-
P
A
A
G
IA
I
K
L
AT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAY
FP
A
S
L
K
TVYP
YDTT
PF
I
EI
SI
Q
E
VFKT
L
V
EAI
I
LV
F
LV
M
YLFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
A
I
L
S
A
V
G
F
T
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
D
KLP
P
KE
A
TH
K
SMG
QIQ
R
AL
VGIAVV
L
S
AVF
M
PM
A
F
MS
G
AT
G
E
IYR
Q
FSIT
LIS
S
M
LL
SV
F
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARF
N
TL
F
EKSTQH
----
Y
TDSTR
S
L
L
RCTGRY
M
V
I
Y
L
L
ICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
L
P
S
G
A
T
MVNTTKVLQ
Q
VT
DYY
LTKEKDN
V
Q
SVF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVT
AII
Q
RA
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AEL
G
TA
S
GFDME
L
LDNGNLGH
E
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
TG
V
RP
N
G
LE
DTPMFK
VNV
N
AA
KA
E
A
M
GV
A
L
S
DI
NQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
ML
P
DN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
GS
PR
L
ERY
N
GI
P
SME
I
LG
EA
AAGK
S
T
G
D
A
MKFMADLVAK
L
-
-
P
A
G
VGYS
W
T
G
--
LS
YQ
EA
L
SSNQAPA
L
Y
A
-
I
S
L
V
V
VFL
A
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LS
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
VEMM
Q
KE
----------
G
KTPI
EA
IIE
A
ARM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
VI
S
H
GAGSG
AQNA
VG
T
GVMGGM
FA
A
T
V
LAI
Y
fig|478008.5.peg.738
Escherichia coli O157:H7 str. EC869 (16-1018/1037)
AI
I
M
M
L
A
G
GLA
I
MN
LPV
A
QYP
Q
I
AP
P
T
I
T
V
S
A
T
YPGA
D
AQ
T
V
E
D
S
VT
Q
VIE
QN
M
NG
L
D
GLM
Y
MSS
T
S
DAA
G
NAS
ITL
T
FE
T
GT
S
PD
I
A
QV
QVQ
NK
LQ
L
A
MPS
LP
EAVQQQ
G
I
SVD-KSSSN
---
I
L
MVA
A
FI
S
DNGSLNQY
DI
A
D
Y
V
ASN
I
KDP
LS
RTA
GVG
S
V
QLF
G
SEY-AM
RI
W
LDP
QK
LN
KYN
L
VPSD
V
IS
Q
I
KVQ
N
NQISG
GQLGG
M
P
QAADQQLNAS
I
I
V
QTR
LQT
P
EEF
GK
I
L
L
KVQQ
DG
SQ
V
L
L
R
DVA
R
VE
L
G
A
E
DYSTV
A
RY
NGK
-
P
A
A
G
IA
I
K
L
AT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAY
FP
A
S
L
K
TVYP
YDTT
PF
I
EI
SI
Q
E
VFKT
L
V
EAI
I
LV
F
LV
M
YLFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
A
I
L
S
A
V
G
F
T
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
D
KLP
P
KE
A
TH
K
SMG
QIQ
R
AL
VGIAVV
L
S
AVF
M
PM
A
F
MS
G
AT
G
E
IYR
Q
FSIT
LIS
S
M
LL
SV
F
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARF
N
TL
F
EKSTQH
----
Y
TDSTR
S
L
L
RCTGRY
M
V
I
Y
L
L
ICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
L
P
S
G
A
T
MVNTTKVLQ
Q
VT
DYY
LTKEKDN
V
Q
SVF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVT
AII
Q
RA
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AEL
G
TA
S
GFDME
L
LDNGNLGH
E
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
TG
V
RP
N
G
LE
DTPMFK
VNV
N
AA
KA
E
A
M
GV
A
L
S
DI
NQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
ML
P
DN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
GS
PR
L
ERY
N
GI
P
SME
I
LG
EA
AAGK
S
T
G
D
A
MKFMADLVAK
L
-
-
P
A
G
VGYS
W
T
G
--
LS
YQ
EA
L
SSNQAPA
L
Y
A
-
I
S
L
V
V
VFL
A
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LS
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
VEMM
Q
KE
----------
G
KTPI
EA
IIE
A
ARM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
VI
S
H
GAGSG
AQNA
VG
T
GVMGGM
FA
A
T
V
LAI
Y
fig|637388.3.peg.1929
Escherichia coli O157:H7 str. FRIK2000 (16-1018/1037)
AI
I
M
M
L
A
G
GLA
I
MN
LPV
A
QYP
Q
I
AP
P
T
I
T
V
S
A
T
YPGA
D
AQ
T
V
E
D
S
VT
Q
VIE
QN
M
NG
L
D
GLM
Y
MSS
T
S
DAA
G
NAS
ITL
T
FE
T
GT
S
PD
I
A
QV
QVQ
NK
LQ
L
A
MPS
LP
EAVQQQ
G
I
SVD-KSSSN
---
I
L
MVA
A
FI
S
DNGSLNQY
DI
A
D
Y
V
ASN
I
KDP
LS
RTA
GVG
S
V
QLF
G
SEY-AM
RI
W
LDP
QK
LN
KYN
L
VPSD
V
IS
Q
I
KVQ
N
NQISG
GQLGG
M
P
QAADQQLNAS
I
I
V
QTR
LQT
P
EEF
GK
I
L
L
KVQQ
DG
SQ
V
L
L
R
DVA
R
VE
L
G
A
E
DYSTV
A
RY
NGK
-
P
A
A
G
IA
I
K
L
AT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAY
FP
A
S
L
K
TVYP
YDTT
PF
I
EI
SI
Q
E
VFKT
L
V
EAI
I
LV
F
LV
M
YLFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
A
I
L
S
A
V
G
F
T
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
D
KLP
P
KE
A
TH
K
SMG
QIQ
R
AL
VGIAVV
L
S
AVF
M
PM
A
F
MS
G
AT
G
E
IYR
Q
FSIT
LIS
S
M
LL
SV
F
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARF
N
TL
F
EKSTQH
----
Y
TDSTR
S
L
L
RCTGRY
M
V
I
Y
L
L
ICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
L
P
S
G
A
T
MVNTTKVLQ
Q
VT
DYY
LTKEKDN
V
Q
SVF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVT
AII
Q
RA
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AEL
G
TA
S
GFDME
L
LDNGNLGH
E
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
TG
V
RP
N
G
LE
DTPMFK
VNV
N
AA
KA
E
A
M
GV
A
L
S
DI
NQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
ML
P
DN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
GS
PR
L
ERY
N
GI
P
SME
I
LG
EA
AAGK
S
T
G
D
A
MKFMADLVAK
L
-
-
P
A
G
VGYS
W
T
G
--
LS
YQ
EA
L
SSNQAPA
L
Y
A
-
I
S
L
V
V
VFL
A
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LS
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
VEMM
Q
KE
----------
G
KTPI
EA
IIE
A
ARM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
VI
S
H
GAGSG
AQNA
VG
T
GVMGGM
FA
A
T
V
LAI
Y
fig|570506.3.peg.91
Escherichia coli O157:H7 str. FRIK966 (16-1018/1037)
AI
I
M
M
L
A
G
GLA
I
MN
LPV
A
QYP
Q
I
AP
P
T
I
T
V
S
A
T
YPGA
D
AQ
T
V
E
D
S
VT
Q
VIE
QN
M
NG
L
D
GLM
Y
MSS
T
S
DAA
G
NAS
ITL
T
FE
T
GT
S
PD
I
A
QV
QVQ
NK
LQ
L
A
MPS
LP
EAVQQQ
G
I
SVD-KSSSN
---
I
L
MVA
A
FI
S
DNGSLNQY
DI
A
D
Y
V
ASN
I
KDP
LS
RTA
GVG
S
V
QLF
G
SEY-AM
RI
W
LDP
QK
LN
KYN
L
VPSD
V
IS
Q
I
KVQ
N
NQISG
GQLGG
M
P
QAADQQLNAS
I
I
V
QTR
LQT
P
EEF
GK
I
L
L
KVQQ
DG
SQ
V
L
L
R
DVA
R
VE
L
G
A
E
DYSTV
A
RY
NGK
-
P
A
A
G
IA
I
K
L
AT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAY
FP
A
S
L
K
TVYP
YDTT
PF
I
EI
SI
Q
E
VFKT
L
V
EAI
I
LV
F
LV
M
YLFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
A
I
L
S
A
V
G
F
T
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
D
KLP
P
KE
A
TH
K
SMG
QIQ
R
AL
VGIAVV
L
S
AVF
M
PM
A
F
MS
G
AT
G
E
IYR
Q
FSIT
LIS
S
M
LL
SV
F
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARF
N
TL
F
EKSTQH
----
Y
TDSTR
S
L
L
RCTGRY
M
V
I
Y
L
L
ICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
L
P
S
G
A
T
MVNTTKVLQ
Q
VT
DYY
LTKEKDN
V
Q
SVF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVT
AII
Q
RA
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AEL
G
TA
S
GFDME
L
LDNGNLGH
E
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
TG
V
RP
N
G
LE
DTPMFK
VNV
N
AA
KA
E
A
M
GV
A
L
S
DI
NQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
ML
P
DN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
GS
PR
L
ERY
N
GI
P
SME
I
LG
EA
AAGK
S
T
G
D
A
MKFMADLVAK
L
-
-
P
A
G
VGYS
W
T
G
--
LS
YQ
EA
L
SSNQAPA
L
Y
A
-
I
S
L
V
V
VFL
A
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LS
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
VEMM
Q
KE
----------
G
KTPI
EA
IIE
A
ARM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
VI
S
H
GAGSG
AQNA
VG
T
GVMGGM
FA
A
T
V
LAI
Y
fig|386585.9.peg.4592
Escherichia coli O157:H7 str. Sakai (16-1018/1037)
AI
I
M
M
L
A
G
GLA
I
MN
LPV
A
QYP
Q
I
AP
P
T
I
T
V
S
A
T
YPGA
D
AQ
T
V
E
D
S
VT
Q
VIE
QN
M
NG
L
D
GLM
Y
MSS
T
S
DAA
G
NAS
ITL
T
FE
T
GT
S
PD
I
A
QV
QVQ
NK
LQ
L
A
MPS
LP
EAVQQQ
G
I
SVD-KSSSN
---
I
L
MVA
A
FI
S
DNGSLNQY
DI
A
D
Y
V
ASN
I
KDP
LS
RTA
GVG
S
V
QLF
G
SEY-AM
RI
W
LDP
QK
LN
KYN
L
VPSD
V
IS
Q
I
KVQ
N
NQISG
GQLGG
M
P
QAADQQLNAS
I
I
V
QTR
LQT
P
EEF
GK
I
L
L
KVQQ
DG
SQ
V
L
L
R
DVA
R
VE
L
G
A
E
DYSTV
A
RY
NGK
-
P
A
A
G
IA
I
K
L
AT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAY
FP
A
S
L
K
TVYP
YDTT
PF
I
EI
SI
Q
E
VFKT
L
V
EAI
I
LV
F
LV
M
YLFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
A
I
L
S
A
V
G
F
T
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
D
KLP
P
KE
A
TH
K
SMG
QIQ
R
AL
VGIAVV
L
S
AVF
M
PM
A
F
MS
G
AT
G
E
IYR
Q
FSIT
LIS
S
M
LL
SV
F
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARF
N
TL
F
EKSTQH
----
Y
TDSTR
S
L
L
RCTGRY
M
V
I
Y
L
L
ICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
L
P
S
G
A
T
MVNTTKVLQ
Q
VT
DYY
LTKEKDN
V
Q
SVF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVT
AII
Q
RA
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AEL
G
TA
S
GFDME
L
LDNGNLGH
E
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
TG
V
RP
N
G
LE
DTPMFK
VNV
N
AA
KA
E
A
M
GV
A
L
S
DI
NQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
ML
P
DN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
GS
PR
L
ERY
N
GI
P
SME
I
LG
EA
AAGK
S
T
G
D
A
MKFMADLVAK
L
-
-
P
A
G
VGYS
W
T
G
--
LS
YQ
EA
L
SSNQAPA
L
Y
A
-
I
S
L
V
V
VFL
A
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LS
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
VEMM
Q
KE
----------
G
KTPI
EA
IIE
A
ARM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
VI
S
H
GAGSG
AQNA
VG
T
GVMGGM
FA
A
T
V
LAI
Y
fig|544404.4.peg.4579
Escherichia coli O157:H7 str. TW14359 (16-1018/1037)
AI
I
M
M
L
A
G
GLA
I
MN
LPV
A
QYP
Q
I
AP
P
T
I
T
V
S
A
T
YPGA
D
AQ
T
V
E
D
S
VT
Q
VIE
QN
M
NG
L
D
GLM
Y
MSS
T
S
DAA
G
NAS
ITL
T
FE
T
GT
S
PD
I
A
QV
QVQ
NK
LQ
L
A
MPS
LP
EAVQQQ
G
I
SVD-KSSSN
---
I
L
MVA
A
FI
S
DNGSLNQY
DI
A
D
Y
V
ASN
I
KDP
LS
RTA
GVG
S
V
QLF
G
SEY-AM
RI
W
LDP
QK
LN
KYN
L
VPSD
V
IS
Q
I
KVQ
N
NQISG
GQLGG
M
P
QAADQQLNAS
I
I
V
QTR
LQT
P
EEF
GK
I
L
L
KVQQ
DG
SQ
V
L
L
R
DVA
R
VE
L
G
A
E
DYSTV
A
RY
NGK
-
P
A
A
G
IA
I
K
L
AT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAY
FP
A
S
L
K
TVYP
YDTT
PF
I
EI
SI
Q
E
VFKT
L
V
EAI
I
LV
F
LV
M
YLFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
A
I
L
S
A
V
G
F
T
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
D
KLP
P
KE
A
TH
K
SMG
QIQ
R
AL
VGIAVV
L
S
AVF
M
PM
A
F
MS
G
AT
G
E
IYR
Q
FSIT
LIS
S
M
LL
SV
F
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARF
N
TL
F
EKSTQH
----
Y
TDSTR
S
L
L
RCTGRY
M
V
I
Y
L
L
ICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
L
P
S
G
A
T
MVNTTKVLQ
Q
VT
DYY
LTKEKDN
V
Q
SVF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVT
AII
Q
RA
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AEL
G
TA
S
GFDME
L
LDNGNLGH
E
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
TG
V
RP
N
G
LE
DTPMFK
VNV
N
AA
KA
E
A
M
GV
A
L
S
DI
NQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
ML
P
DN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
GS
PR
L
ERY
N
GI
P
SME
I
LG
EA
AAGK
S
T
G
D
A
MKFMADLVAK
L
-
-
P
A
G
VGYS
W
T
G
--
LS
YQ
EA
L
SSNQAPA
L
Y
A
-
I
S
L
V
V
VFL
A
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LS
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
VEMM
Q
KE
----------
G
KTPI
EA
IIE
A
ARM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
VI
S
H
GAGSG
AQNA
VG
T
GVMGGM
FA
A
T
V
LAI
Y
fig|502346.5.peg.2251
Escherichia coli O157:H7 str. TW14588 (16-1018/1037)
AI
I
M
M
L
A
G
GLA
I
MN
LPV
A
QYP
Q
I
AP
P
T
I
T
V
S
A
T
YPGA
D
AQ
T
V
E
D
S
VT
Q
VIE
QN
M
NG
L
D
GLM
Y
MSS
T
S
DAA
G
NAS
ITL
T
FE
T
GT
S
PD
I
A
QV
QVQ
NK
LQ
L
A
MPS
LP
EAVQQQ
G
I
SVD-KSSSN
---
I
L
MVA
A
FI
S
DNGSLNQY
DI
A
D
Y
V
ASN
I
KDP
LS
RTA
GVG
S
V
QLF
G
SEY-AM
RI
W
LDP
QK
LN
KYN
L
VPSD
V
IS
Q
I
KVQ
N
NQISG
GQLGG
M
P
QAADQQLNAS
I
I
V
QTR
LQT
P
EEF
GK
I
L
L
KVQQ
DG
SQ
V
L
L
R
DVA
R
VE
L
G
A
E
DYSTV
A
RY
NGK
-
P
A
A
G
IA
I
K
L
AT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAY
FP
A
S
L
K
TVYP
YDTT
PF
I
EI
SI
Q
E
VFKT
L
V
EAI
I
LV
F
LV
M
YLFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
A
I
L
S
A
V
G
F
T
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
D
KLP
P
KE
A
TH
K
SMG
QIQ
R
AL
VGIAVV
L
S
AVF
M
PM
A
F
MS
G
AT
G
E
IYR
Q
FSIT
LIS
S
M
LL
SV
F
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARF
N
TL
F
EKSTQH
----
Y
TDSTR
S
L
L
RCTGRY
M
V
I
Y
L
L
ICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
L
P
S
G
A
T
MVNTTKVLQ
Q
VT
DYY
LTKEKDN
V
Q
SVF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVT
AII
Q
RA
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AEL
G
TA
S
GFDME
L
LDNGNLGH
E
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
TG
V
RP
N
G
LE
DTPMFK
VNV
N
AA
KA
E
A
M
GV
A
L
S
DI
NQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
ML
P
DN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
GS
PR
L
ERY
N
GI
P
SME
I
LG
EA
AAGK
S
T
G
D
A
MKFMADLVAK
L
-
-
P
A
G
VGYS
W
T
G
--
LS
YQ
EA
L
SSNQAPA
L
Y
A
-
I
S
L
V
V
VFL
A
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LS
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
VEMM
Q
KE
----------
G
KTPI
EA
IIE
A
ARM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
VI
S
H
GAGSG
AQNA
VG
T
GVMGGM
FA
A
T
V
LAI
Y
fig|701177.3.peg.4269
Escherichia coli O55:H7 str. CB9615 (16-1018/1037)
AI
I
M
M
L
A
G
GLA
I
MN
LPV
A
QYP
Q
I
AP
P
T
I
T
V
S
A
T
YPGA
D
AQ
T
V
E
D
S
VT
Q
VIE
QN
M
NG
L
D
GLM
Y
MSS
T
S
DAA
G
NAS
ITL
T
FE
T
GT
S
PD
I
A
QV
QVQ
NK
LQ
L
A
MPS
LP
EAVQQQ
G
I
SVD-KSSSN
---
I
L
MVA
A
FI
S
DNGSLNQY
DI
A
D
Y
V
ASN
I
KDP
LS
RTA
GVG
S
V
QLF
G
SEY-AM
RI
W
LDP
QK
LN
KYN
L
VPSD
V
IS
Q
I
KVQ
N
NQISG
GQLGG
M
P
QAADQQLNAS
I
I
V
QTR
LQT
P
EEF
GK
I
L
L
KVQQ
DG
SQ
V
L
L
R
DVA
R
VE
L
G
A
E
DYSTV
A
RY
NGK
-
P
A
A
G
IA
I
K
L
AT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAY
FP
A
S
L
K
TVYP
YDTT
PF
I
EI
SI
Q
E
VFKT
L
V
EAI
I
LV
F
LV
M
YLFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
A
I
L
S
A
V
G
F
T
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
D
KLP
P
KE
A
TH
K
SMG
QIQ
R
AL
VGIAVV
L
S
AVF
M
PM
A
F
MS
G
AT
G
E
IYR
Q
FSIT
LIS
S
M
LL
SV
F
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARF
N
TL
F
EKSTQH
----
Y
TDSTR
S
L
L
RCTGRY
M
V
I
Y
L
L
ICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
L
P
S
G
A
T
MVNTTKVLQ
Q
VT
DYY
LTKEKDN
V
Q
SVF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVT
AII
Q
RA
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AEL
G
TA
S
GFDME
L
LDNGNLGH
E
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
TG
V
RP
N
G
LE
DTPMFK
VNV
N
AA
KA
E
A
M
GV
A
L
S
DI
NQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
ML
P
DN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
GS
PR
L
ERY
N
GI
P
SME
I
LG
EA
AAGK
S
T
G
D
A
MKFMADLVAK
L
-
-
P
A
G
VGYS
W
T
G
--
LS
YQ
EA
L
SSNQAPA
L
Y
A
-
I
S
L
V
V
VFL
A
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LS
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
VEMM
Q
KE
----------
G
KTPI
EA
IIE
A
ARM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
VI
S
H
GAGSG
AQNA
VG
T
GVMGGM
FA
A
T
V
LAI
Y
fig|679204.3.peg.4608
Escherichia coli MS 145-7 (16-1018/1037)
AI
I
M
M
L
A
G
GLA
I
MN
LPV
A
QYP
Q
I
AP
P
T
I
T
V
S
A
T
YPGA
D
AQ
T
V
E
D
S
VT
Q
VIE
QN
M
NG
L
D
GLM
Y
MSS
T
S
DAA
G
NAS
ITL
T
FE
T
GT
S
PD
I
A
QV
QVQ
NK
LQ
L
A
MPS
LP
EAVQQQ
G
I
SVD-KSSSN
---
I
L
MVA
A
FI
S
DNGSLNQY
DI
A
D
Y
V
ASN
I
KDP
LS
RTA
GVG
S
V
QLF
G
SEY-AM
RI
W
LDP
QK
LN
KYN
L
VPSD
V
IS
Q
I
KVQ
N
NQISG
GQLGG
M
P
QAADQQLNAS
I
I
V
QTR
LQT
P
EEF
GK
I
L
L
KVQQ
DG
SQ
V
L
L
R
DVA
R
VE
L
G
A
E
DYSTV
A
RY
NGK
-
P
A
A
G
IA
I
K
L
AT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAY
FP
A
S
L
K
TVYP
YDTT
PF
I
EI
SI
Q
E
VFKT
L
V
EAI
I
LV
F
LV
M
YLFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
A
I
L
S
A
V
G
F
T
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
D
KLP
P
KE
A
TH
K
SMG
QIQ
R
AL
VGIAVV
L
S
AVF
M
PM
A
F
MS
G
AT
G
E
IYR
Q
FSIT
LIS
S
M
LL
SV
F
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARF
N
TL
F
EKSTQH
----
Y
TDSTR
S
L
L
RCTGRY
M
V
VY
L
L
ICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
L
P
S
G
A
T
MVNTTKVLQ
Q
VT
DYY
LTKEKDN
V
Q
SVF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVT
AII
Q
RA
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AEL
G
TA
S
GFDME
L
LDNGNLGH
E
K
L
TQARN
E
L
LSL
A
AQS
P
DQ
V
TG
V
RP
N
G
LE
DTPMFK
VNV
N
AA
KA
E
A
M
GV
A
L
S
DI
NQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
ML
P
DN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
GS
PR
L
ERY
N
GI
P
SME
I
LG
EA
AAGK
S
T
G
D
A
MKFMADLVAK
L
-
-
P
A
G
VGYS
W
T
G
--
LS
YQ
EA
L
SSNQAPA
L
Y
A
-
I
S
L
V
V
VFL
A
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LS
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
VKMM
Q
KE
----------
G
KTPI
EA
IIE
A
ARM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
VI
S
H
GAGSG
AQNA
VG
T
GVMGGM
FA
A
T
V
LAI
Y
fig|749548.3.peg.3917
Escherichia coli MS 196-1 (16-1018/1037)
AI
I
M
M
L
A
G
GLA
I
MN
LPV
A
QYP
Q
I
AP
P
T
I
T
V
S
A
T
YPGA
D
AQ
T
V
E
D
S
VT
Q
VIE
QN
M
NG
L
D
GLM
Y
MSS
T
S
DAA
G
NAS
ITL
T
FE
T
GT
S
PD
I
A
QV
QVQ
NK
LQ
L
A
MPS
LP
EAVQQQ
G
I
SVD-KSSSN
---
I
L
MVA
A
FI
S
DNGSLNQY
DI
A
D
Y
V
ASN
I
KDP
LS
RTA
GVG
S
V
QLF
G
SEY-AM
RI
W
LDP
QK
LN
KYN
L
VPSD
V
IS
Q
I
KVQ
N
NQISG
GQLGG
M
P
QAADQQLNAS
I
I
V
QTR
LQT
P
EEF
GK
I
L
L
KVQQ
DG
SQ
V
L
L
R
DVA
R
VE
L
G
A
E
DYSTV
A
RY
NGK
-
P
A
A
G
IA
I
K
L
AA
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAY
FP
A
S
L
K
TVYP
YDTT
PF
I
EI
SI
Q
E
VFKT
L
V
EAI
I
LV
F
LV
M
YLFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
A
I
L
S
A
V
G
F
T
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
D
KLP
P
KE
A
TH
K
SMG
QIQ
R
AL
VGIAVV
L
S
AVF
M
PM
A
F
MS
G
AT
G
E
IYR
Q
FSIT
LIS
S
M
LL
SV
F
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARF
N
TL
F
EKSTQH
----
Y
TDSTR
S
L
L
RCTGRY
M
V
VY
L
L
ICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
L
P
S
G
A
T
MVNTTKVLQ
Q
VT
DYY
LTKEKDN
V
Q
SVF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVT
AII
Q
RA
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AEL
G
TA
S
GFDME
L
LDNGNLGH
E
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
TG
V
RP
N
G
LE
DTPMFK
VNV
N
AA
KA
E
A
M
GV
A
L
S
DI
NQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
ML
P
DN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
GS
PR
L
ERY
N
GI
P
SME
I
LG
EA
AAGK
S
T
G
D
A
MKFMADLVAK
L
-
-
P
A
G
VGYS
W
T
G
--
LA
YQ
EA
L
SSNQAPA
L
Y
A
-
I
S
L
V
V
VFL
A
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LS
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
VEMM
Q
KE
----------
G
KTPI
EA
IIE
A
ARM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
VI
S
H
GAGSG
AQNA
VG
T
GVMGGM
FA
A
T
V
LAI
Y
fig|670888.3.peg.2726
Escherichia coli 1827-70 (16-1018/1037)
AI
I
M
M
L
A
G
GLA
I
MN
LPV
A
QYP
Q
I
AP
P
T
I
T
V
S
A
T
YPGA
D
AQ
T
V
E
D
S
VT
Q
VIE
QN
M
NG
L
D
GLM
Y
MSS
T
S
DAA
G
NAS
ITL
T
FE
T
GT
S
PD
I
A
QV
QVQ
NK
LQ
L
A
MPS
LP
EAVQQQ
G
I
SVD-KSSSN
---
I
L
MVA
A
FI
S
DNGSLNQY
DI
A
D
Y
V
ASN
I
KDP
LS
RTA
GVG
S
V
QLF
G
SEY-AM
RI
W
LDP
QK
LN
KYN
L
VPSD
V
IS
Q
I
KVQ
N
NQISG
GQLGG
M
P
QAADQQLNAS
I
I
V
QTR
LQT
P
EEF
GK
I
L
L
KVQQ
DG
SQ
V
L
L
R
DVA
R
VE
L
G
A
E
DYSTV
A
RY
NGK
-
P
A
A
G
IA
I
K
L
AA
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAY
FP
A
S
L
K
TVYP
YDTT
PF
I
EI
SI
Q
E
VFKT
L
V
EAI
I
LV
F
LV
M
YLFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
A
I
L
S
A
V
G
F
T
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
D
KLP
P
KE
A
TH
K
SMG
QIQ
R
AL
VGIAVV
L
S
AVF
M
PM
A
F
MS
G
AT
G
E
IYR
Q
FSIT
LIS
S
M
LL
SV
F
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARF
N
TL
F
EKSTQH
----
Y
TDSTR
S
L
L
RCTGRY
M
V
VY
L
L
ICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
L
P
S
G
A
T
MVNTTKVLQ
Q
VT
DYY
LTKEKDN
V
Q
SVF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVT
AII
Q
RA
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AEL
G
TA
S
GFDME
L
LDNGNLGH
E
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
TG
V
RP
N
G
LE
DTPMFK
VNV
N
AA
KA
E
A
M
GV
A
L
S
DI
NQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
ML
P
DN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
GS
PR
L
ERY
N
GI
P
SME
I
LG
EA
AAGK
S
T
G
D
A
MKFMADLVAK
L
-
-
P
A
G
VGYS
W
T
G
--
LS
YQ
EA
L
SSNQAPA
L
Y
A
-
I
S
L
V
V
VFL
A
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LS
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
VEMM
Q
KE
----------
G
KTPI
EA
IIE
A
ARM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
VI
S
H
GAGSG
AQNA
VG
T
GVMGGM
FA
A
T
V
LAI
Y
fig|344610.3.peg.88
Escherichia coli 53638 (16-1018/1037)
AI
I
M
M
L
A
G
GLA
I
MN
LPV
A
QYP
Q
I
AP
P
T
I
T
V
S
A
T
YPGA
D
AQ
T
V
E
D
S
VT
Q
VIE
QN
M
NG
L
D
GLM
Y
MSS
T
S
DAA
G
NAS
ITL
T
FE
T
GT
S
PD
I
A
QV
QVQ
NK
LQ
L
A
MPS
LP
EAVQQQ
G
I
SVD-KSSSN
---
I
L
MVA
A
FI
S
DNGSLNQY
DI
A
D
Y
V
ASN
I
KDP
LS
RTA
GVG
S
V
QLF
G
SEY-AM
RI
W
LDP
QK
LN
KYN
L
VPSD
V
IS
Q
I
KVQ
N
NQISG
GQLGG
M
P
QAADQQLNAS
I
I
V
QTR
LQT
P
EEF
GK
I
L
L
KVQQ
DG
SQ
V
L
L
R
DVA
R
VE
L
G
A
E
DYSTV
A
RY
NGK
-
P
A
A
G
IA
I
K
L
AA
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAY
FP
A
S
L
K
TVYP
YDTT
PF
I
EI
SI
Q
E
VFKT
L
V
EAI
I
LV
F
LV
M
YLFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
A
I
L
S
A
V
G
F
T
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
D
KLP
P
KE
A
TH
K
SMG
QIQ
R
AL
VGIAVV
L
S
AVF
M
PM
A
F
MS
G
AT
G
E
IYR
Q
FSIT
LIS
S
M
LL
SV
F
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARF
N
TL
F
EKSTQH
----
Y
TDSTR
S
L
L
RCTGRY
M
V
VY
L
L
ICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
L
P
S
G
A
T
MVNTTKVLQ
Q
VT
DYY
LTKEKDN
V
Q
SVF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVT
AII
Q
RA
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AEL
G
TA
S
GFDME
L
LDNGNLGH
E
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
TG
V
RP
N
G
LE
DTPMFK
VNV
N
AA
KA
E
A
M
GV
A
L
S
DI
NQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
ML
P
DN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
GS
PR
L
ERY
N
GI
P
SME
I
LG
EA
AAGK
S
T
G
D
A
MKFMADLVAK
L
-
-
P
A
G
VGYS
W
T
G
--
LS
YQ
EA
L
SSNQAPA
L
Y
A
-
I
S
L
V
V
VFL
A
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LS
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
VEMM
Q
KE
----------
G
KTPI
EA
IIE
A
ARM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
VI
S
H
GAGSG
AQNA
VG
T
GVMGGM
FA
A
T
V
LAI
Y
fig|344610.7.peg.2711
Escherichia coli 53638 (16-1018/1037)
AI
I
M
M
L
A
G
GLA
I
MN
LPV
A
QYP
Q
I
AP
P
T
I
T
V
S
A
T
YPGA
D
AQ
T
V
E
D
S
VT
Q
VIE
QN
M
NG
L
D
GLM
Y
MSS
T
S
DAA
G
NAS
ITL
T
FE
T
GT
S
PD
I
A
QV
QVQ
NK
LQ
L
A
MPS
LP
EAVQQQ
G
I
SVD-KSSSN
---
I
L
MVA
A
FI
S
DNGSLNQY
DI
A
D
Y
V
ASN
I
KDP
LS
RTA
GVG
S
V
QLF
G
SEY-AM
RI
W
LDP
QK
LN
KYN
L
VPSD
V
IS
Q
I
KVQ
N
NQISG
GQLGG
M
P
QAADQQLNAS
I
I
V
QTR
LQT
P
EEF
GK
I
L
L
KVQQ
DG
SQ
V
L
L
R
DVA
R
VE
L
G
A
E
DYSTV
A
RY
NGK
-
P
A
A
G
IA
I
K
L
AA
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAY
FP
A
S
L
K
TVYP
YDTT
PF
I
EI
SI
Q
E
VFKT
L
V
EAI
I
LV
F
LV
M
YLFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
A
I
L
S
A
V
G
F
T
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
D
KLP
P
KE
A
TH
K
SMG
QIQ
R
AL
VGIAVV
L
S
AVF
M
PM
A
F
MS
G
AT
G
E
IYR
Q
FSIT
LIS
S
M
LL
SV
F
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARF
N
TL
F
EKSTQH
----
Y
TDSTR
S
L
L
RCTGRY
M
V
VY
L
L
ICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
L
P
S
G
A
T
MVNTTKVLQ
Q
VT
DYY
LTKEKDN
V
Q
SVF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVT
AII
Q
RA
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AEL
G
TA
S
GFDME
L
LDNGNLGH
E
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
TG
V
RP
N
G
LE
DTPMFK
VNV
N
AA
KA
E
A
M
GV
A
L
S
DI
NQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
ML
P
DN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
GS
PR
L
ERY
N
GI
P
SME
I
LG
EA
AAGK
S
T
G
D
A
MKFMADLVAK
L
-
-
P
A
G
VGYS
W
T
G
--
LS
YQ
EA
L
SSNQAPA
L
Y
A
-
I
S
L
V
V
VFL
A
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LS
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
VEMM
Q
KE
----------
G
KTPI
EA
IIE
A
ARM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
VI
S
H
GAGSG
AQNA
VG
T
GVMGGM
FA
A
T
V
LAI
Y
fig|481805.3.peg.211
Escherichia coli ATCC 8739 (16-1018/1037)
AI
I
M
M
L
A
G
GLA
I
MN
LPV
A
QYP
Q
I
AP
P
T
I
T
V
S
A
T
YPGA
D
AQ
T
V
E
D
S
VT
Q
VIE
QN
M
NG
L
D
GLM
Y
MSS
T
S
DAA
G
NAS
ITL
T
FE
T
GT
S
PD
I
A
QV
QVQ
NK
LQ
L
A
MPS
LP
EAVQQQ
G
I
SVD-KSSSN
---
I
L
MVA
A
FI
S
DNGSLNQY
DI
A
D
Y
V
ASN
I
KDP
LS
RTA
GVG
S
V
QLF
G
SEY-AM
RI
W
LDP
QK
LN
KYN
L
VPSD
V
IS
Q
I
KVQ
N
NQISG
GQLGG
M
P
QAADQQLNAS
I
I
V
QTR
LQT
P
EEF
GK
I
L
L
KVQQ
DG
SQ
V
L
L
R
DVA
R
VE
L
G
A
E
DYSTV
A
RY
NGK
-
P
A
A
G
IA
I
K
L
AA
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAY
FP
A
S
L
K
TVYP
YDTT
PF
I
EI
SI
Q
E
VFKT
L
V
EAI
I
LV
F
LV
M
YLFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
A
I
L
S
A
V
G
F
T
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
D
KLP
P
KE
A
TH
K
SMG
QIQ
R
AL
VGIAVV
L
S
AVF
M
PM
A
F
MS
G
AT
G
E
IYR
Q
FSIT
LIS
S
M
LL
SV
F
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARF
N
TL
F
EKSTQH
----
Y
TDSTR
S
L
L
RCTGRY
M
V
VY
L
L
ICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
L
P
S
G
A
T
MVNTTKVLQ
Q
VT
DYY
LTKEKDN
V
Q
SVF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVT
AII
Q
RA
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AEL
G
TA
S
GFDME
L
LDNGNLGH
E
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
TG
V
RP
N
G
LE
DTPMFK
VNV
N
AA
KA
E
A
M
GV
A
L
S
DI
NQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
ML
P
DN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
GS
PR
L
ERY
N
GI
P
SME
I
LG
EA
AAGK
S
T
G
D
A
MKFMADLVAK
L
-
-
P
A
G
VGYS
W
T
G
--
LS
YQ
EA
L
SSNQAPA
L
Y
A
-
I
S
L
V
V
VFL
A
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LS
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
VEMM
Q
KE
----------
G
KTPI
EA
IIE
A
ARM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
VI
S
H
GAGSG
AQNA
VG
T
GVMGGM
FA
A
T
V
LAI
Y
fig|481805.6.peg.218
Escherichia coli ATCC 8739 (16-1018/1037)
AI
I
M
M
L
A
G
GLA
I
MN
LPV
A
QYP
Q
I
AP
P
T
I
T
V
S
A
T
YPGA
D
AQ
T
V
E
D
S
VT
Q
VIE
QN
M
NG
L
D
GLM
Y
MSS
T
S
DAA
G
NAS
ITL
T
FE
T
GT
S
PD
I
A
QV
QVQ
NK
LQ
L
A
MPS
LP
EAVQQQ
G
I
SVD-KSSSN
---
I
L
MVA
A
FI
S
DNGSLNQY
DI
A
D
Y
V
ASN
I
KDP
LS
RTA
GVG
S
V
QLF
G
SEY-AM
RI
W
LDP
QK
LN
KYN
L
VPSD
V
IS
Q
I
KVQ
N
NQISG
GQLGG
M
P
QAADQQLNAS
I
I
V
QTR
LQT
P
EEF
GK
I
L
L
KVQQ
DG
SQ
V
L
L
R
DVA
R
VE
L
G
A
E
DYSTV
A
RY
NGK
-
P
A
A
G
IA
I
K
L
AA
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAY
FP
A
S
L
K
TVYP
YDTT
PF
I
EI
SI
Q
E
VFKT
L
V
EAI
I
LV
F
LV
M
YLFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
A
I
L
S
A
V
G
F
T
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
D
KLP
P
KE
A
TH
K
SMG
QIQ
R
AL
VGIAVV
L
S
AVF
M
PM
A
F
MS
G
AT
G
E
IYR
Q
FSIT
LIS
S
M
LL
SV
F
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARF
N
TL
F
EKSTQH
----
Y
TDSTR
S
L
L
RCTGRY
M
V
VY
L
L
ICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
L
P
S
G
A
T
MVNTTKVLQ
Q
VT
DYY
LTKEKDN
V
Q
SVF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVT
AII
Q
RA
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AEL
G
TA
S
GFDME
L
LDNGNLGH
E
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
TG
V
RP
N
G
LE
DTPMFK
VNV
N
AA
KA
E
A
M
GV
A
L
S
DI
NQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
ML
P
DN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
GS
PR
L
ERY
N
GI
P
SME
I
LG
EA
AAGK
S
T
G
D
A
MKFMADLVAK
L
-
-
P
A
G
VGYS
W
T
G
--
LS
YQ
EA
L
SSNQAPA
L
Y
A
-
I
S
L
V
V
VFL
A
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LS
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
VEMM
Q
KE
----------
G
KTPI
EA
IIE
A
ARM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
VI
S
H
GAGSG
AQNA
VG
T
GVMGGM
FA
A
T
V
LAI
Y
fig|413997.3.peg.3526
Escherichia coli B str. REL606 (16-1018/1037)
AI
I
M
M
L
A
G
GLA
I
MN
LPV
A
QYP
Q
I
AP
P
T
I
T
V
S
A
T
YPGA
D
AQ
T
V
E
D
S
VT
Q
VIE
QN
M
NG
L
D
GLM
Y
MSS
T
S
DAA
G
NAS
ITL
T
FE
T
GT
S
PD
I
A
QV
QVQ
NK
LQ
L
A
MPS
LP
EAVQQQ
G
I
SVD-KSSSN
---
I
L
MVA
A
FI
S
DNGSLNQY
DI
A
D
Y
V
ASN
I
KDP
LS
RTA
GVG
S
V
QLF
G
SEY-AM
RI
W
LDP
QK
LN
KYN
L
VPSD
V
IS
Q
I
KVQ
N
NQISG
GQLGG
M
P
QAADQQLNAS
I
I
V
QTR
LQT
P
EEF
GK
I
L
L
KVQQ
DG
SQ
V
L
L
R
DVA
R
VE
L
G
A
E
DYSTV
A
RY
NGK
-
P
A
A
G
IA
I
K
L
AA
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAY
FP
A
S
L
K
TVYP
YDTT
PF
I
EI
SI
Q
E
VFKT
L
V
EAI
I
LV
F
LV
M
YLFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
A
I
L
S
A
V
G
F
T
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
D
KLP
P
KE
A
TH
K
SMG
QIQ
R
AL
VGIAVV
L
S
AVF
M
PM
A
F
MS
G
AT
G
E
IYR
Q
FSIT
LIS
S
M
LL
SV
F
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARF
N
TL
F
EKSTQH
----
Y
TDSTR
S
L
L
RCTGRY
M
V
VY
L
L
ICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
L
P
S
G
A
T
MVNTTKVLQ
Q
VT
DYY
LTKEKDN
V
Q
SVF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVT
AII
Q
RA
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AEL
G
TA
S
GFDME
L
LDNGNLGH
E
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
TG
V
RP
N
G
LE
DTPMFK
VNV
N
AA
KA
E
A
M
GV
A
L
S
DI
NQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
ML
P
DN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
GS
PR
L
ERY
N
GI
P
SME
I
LG
EA
AAGK
S
T
G
D
A
MKFMADLVAK
L
-
-
P
A
G
VGYS
W
T
G
--
LS
YQ
EA
L
SSNQAPA
L
Y
A
-
I
S
L
V
V
VFL
A
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LS
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
VEMM
Q
KE
----------
G
KTPI
EA
IIE
A
ARM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
VI
S
H
GAGSG
AQNA
VG
T
GVMGGM
FA
A
T
V
LAI
Y
fig|511693.5.peg.3542
Escherichia coli BL21 (16-1018/1037)
AI
I
M
M
L
A
G
GLA
I
MN
LPV
A
QYP
Q
I
AP
P
T
I
T
V
S
A
T
YPGA
D
AQ
T
V
E
D
S
VT
Q
VIE
QN
M
NG
L
D
GLM
Y
MSS
T
S
DAA
G
NAS
ITL
T
FE
T
GT
S
PD
I
A
QV
QVQ
NK
LQ
L
A
MPS
LP
EAVQQQ
G
I
SVD-KSSSN
---
I
L
MVA
A
FI
S
DNGSLNQY
DI
A
D
Y
V
ASN
I
KDP
LS
RTA
GVG
S
V
QLF
G
SEY-AM
RI
W
LDP
QK
LN
KYN
L
VPSD
V
IS
Q
I
KVQ
N
NQISG
GQLGG
M
P
QAADQQLNAS
I
I
V
QTR
LQT
P
EEF
GK
I
L
L
KVQQ
DG
SQ
V
L
L
R
DVA
R
VE
L
G
A
E
DYSTV
A
RY
NGK
-
P
A
A
G
IA
I
K
L
AA
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAY
FP
A
S
L
K
TVYP
YDTT
PF
I
EI
SI
Q
E
VFKT
L
V
EAI
I
LV
F
LV
M
YLFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
A
I
L
S
A
V
G
F
T
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
D
KLP
P
KE
A
TH
K
SMG
QIQ
R
AL
VGIAVV
L
S
AVF
M
PM
A
F
MS
G
AT
G
E
IYR
Q
FSIT
LIS
S
M
LL
SV
F
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARF
N
TL
F
EKSTQH
----
Y
TDSTR
S
L
L
RCTGRY
M
V
VY
L
L
ICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
L
P
S
G
A
T
MVNTTKVLQ
Q
VT
DYY
LTKEKDN
V
Q
SVF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVT
AII
Q
RA
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AEL
G
TA
S
GFDME
L
LDNGNLGH
E
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
TG
V
RP
N
G
LE
DTPMFK
VNV
N
AA
KA
E
A
M
GV
A
L
S
DI
NQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
ML
P
DN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
GS
PR
L
ERY
N
GI
P
SME
I
LG
EA
AAGK
S
T
G
D
A
MKFMADLVAK
L
-
-
P
A
G
VGYS
W
T
G
--
LS
YQ
EA
L
SSNQAPA
L
Y
A
-
I
S
L
V
V
VFL
A
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LS
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
VEMM
Q
KE
----------
G
KTPI
EA
IIE
A
ARM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
VI
S
H
GAGSG
AQNA
VG
T
GVMGGM
FA
A
T
V
LAI
Y
fig|469008.4.peg.238
Escherichia coli BL21(DE3) (16-1018/1037)
AI
I
M
M
L
A
G
GLA
I
MN
LPV
A
QYP
Q
I
AP
P
T
I
T
V
S
A
T
YPGA
D
AQ
T
V
E
D
S
VT
Q
VIE
QN
M
NG
L
D
GLM
Y
MSS
T
S
DAA
G
NAS
ITL
T
FE
T
GT
S
PD
I
A
QV
QVQ
NK
LQ
L
A
MPS
LP
EAVQQQ
G
I
SVD-KSSSN
---
I
L
MVA
A
FI
S
DNGSLNQY
DI
A
D
Y
V
ASN
I
KDP
LS
RTA
GVG
S
V
QLF
G
SEY-AM
RI
W
LDP
QK
LN
KYN
L
VPSD
V
IS
Q
I
KVQ
N
NQISG
GQLGG
M
P
QAADQQLNAS
I
I
V
QTR
LQT
P
EEF
GK
I
L
L
KVQQ
DG
SQ
V
L
L
R
DVA
R
VE
L
G
A
E
DYSTV
A
RY
NGK
-
P
A
A
G
IA
I
K
L
AA
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAY
FP
A
S
L
K
TVYP
YDTT
PF
I
EI
SI
Q
E
VFKT
L
V
EAI
I
LV
F
LV
M
YLFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
A
I
L
S
A
V
G
F
T
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
D
KLP
P
KE
A
TH
K
SMG
QIQ
R
AL
VGIAVV
L
S
AVF
M
PM
A
F
MS
G
AT
G
E
IYR
Q
FSIT
LIS
S
M
LL
SV
F
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARF
N
TL
F
EKSTQH
----
Y
TDSTR
S
L
L
RCTGRY
M
V
VY
L
L
ICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
L
P
S
G
A
T
MVNTTKVLQ
Q
VT
DYY
LTKEKDN
V
Q
SVF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVT
AII
Q
RA
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AEL
G
TA
S
GFDME
L
LDNGNLGH
E
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
TG
V
RP
N
G
LE
DTPMFK
VNV
N
AA
KA
E
A
M
GV
A
L
S
DI
NQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
ML
P
DN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
GS
PR
L
ERY
N
GI
P
SME
I
LG
EA
AAGK
S
T
G
D
A
MKFMADLVAK
L
-
-
P
A
G
VGYS
W
T
G
--
LS
YQ
EA
L
SSNQAPA
L
Y
A
-
I
S
L
V
V
VFL
A
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LS
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
VEMM
Q
KE
----------
G
KTPI
EA
IIE
A
ARM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
VI
S
H
GAGSG
AQNA
VG
T
GVMGGM
FA
A
T
V
LAI
Y
fig|595496.3.peg.3503
Escherichia coli BW2952 (16-1018/1037)
AI
I
M
M
L
A
G
GLA
I
MN
LPV
A
QYP
Q
I
AP
P
T
I
T
V
S
A
T
YPGA
D
AQ
T
V
E
D
S
VT
Q
VIE
QN
M
NG
L
D
GLM
Y
MSS
T
S
DAA
G
NAS
ITL
T
FE
T
GT
S
PD
I
A
QV
QVQ
NK
LQ
L
A
MPS
LP
EAVQQQ
G
I
SVD-KSSSN
---
I
L
MVA
A
FI
S
DNGSLNQY
DI
A
D
Y
V
ASN
I
KDP
LS
RTA
GVG
S
V
QLF
G
SEY-AM
RI
W
LDP
QK
LN
KYN
L
VPSD
V
IS
Q
I
KVQ
N
NQISG
GQLGG
M
P
QAADQQLNAS
I
I
V
QTR
LQT
P
EEF
GK
I
L
L
KVQQ
DG
SQ
V
L
L
R
DVA
R
VE
L
G
A
E
DYSTV
A
RY
NGK
-
P
A
A
G
IA
I
K
L
AA
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAY
FP
A
S
L
K
TVYP
YDTT
PF
I
EI
SI
Q
E
VFKT
L
V
EAI
I
LV
F
LV
M
YLFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
A
I
L
S
A
V
G
F
T
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
D
KLP
P
KE
A
TH
K
SMG
QIQ
R
AL
VGIAVV
L
S
AVF
M
PM
A
F
MS
G
AT
G
E
IYR
Q
FSIT
LIS
S
M
LL
SV
F
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARF
N
TL
F
EKSTQH
----
Y
TDSTR
S
L
L
RCTGRY
M
V
VY
L
L
ICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
L
P
S
G
A
T
MVNTTKVLQ
Q
VT
DYY
LTKEKDN
V
Q
SVF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVT
AII
Q
RA
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AEL
G
TA
S
GFDME
L
LDNGNLGH
E
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
TG
V
RP
N
G
LE
DTPMFK
VNV
N
AA
KA
E
A
M
GV
A
L
S
DI
NQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
ML
P
DN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
GS
PR
L
ERY
N
GI
P
SME
I
LG
EA
AAGK
S
T
G
D
A
MKFMADLVAK
L
-
-
P
A
G
VGYS
W
T
G
--
LS
YQ
EA
L
SSNQAPA
L
Y
A
-
I
S
L
V
V
VFL
A
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LS
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
VEMM
Q
KE
----------
G
KTPI
EA
IIE
A
ARM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
VI
S
H
GAGSG
AQNA
VG
T
GVMGGM
FA
A
T
V
LAI
Y
fig|536056.3.peg.206
Escherichia coli DH1 (16-1018/1037)
AI
I
M
M
L
A
G
GLA
I
MN
LPV
A
QYP
Q
I
AP
P
T
I
T
V
S
A
T
YPGA
D
AQ
T
V
E
D
S
VT
Q
VIE
QN
M
NG
L
D
GLM
Y
MSS
T
S
DAA
G
NAS
ITL
T
FE
T
GT
S
PD
I
A
QV
QVQ
NK
LQ
L
A
MPS
LP
EAVQQQ
G
I
SVD-KSSSN
---
I
L
MVA
A
FI
S
DNGSLNQY
DI
A
D
Y
V
ASN
I
KDP
LS
RTA
GVG
S
V
QLF
G
SEY-AM
RI
W
LDP
QK
LN
KYN
L
VPSD
V
IS
Q
I
KVQ
N
NQISG
GQLGG
M
P
QAADQQLNAS
I
I
V
QTR
LQT
P
EEF
GK
I
L
L
KVQQ
DG
SQ
V
L
L
R
DVA
R
VE
L
G
A
E
DYSTV
A
RY
NGK
-
P
A
A
G
IA
I
K
L
AA
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAY
FP
A
S
L
K
TVYP
YDTT
PF
I
EI
SI
Q
E
VFKT
L
V
EAI
I
LV
F
LV
M
YLFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
A
I
L
S
A
V
G
F
T
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
D
KLP
P
KE
A
TH
K
SMG
QIQ
R
AL
VGIAVV
L
S
AVF
M
PM
A
F
MS
G
AT
G
E
IYR
Q
FSIT
LIS
S
M
LL
SV
F
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARF
N
TL
F
EKSTQH
----
Y
TDSTR
S
L
L
RCTGRY
M
V
VY
L
L
ICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
L
P
S
G
A
T
MVNTTKVLQ
Q
VT
DYY
LTKEKDN
V
Q
SVF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVT
AII
Q
RA
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AEL
G
TA
S
GFDME
L
LDNGNLGH
E
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
TG
V
RP
N
G
LE
DTPMFK
VNV
N
AA
KA
E
A
M
GV
A
L
S
DI
NQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
ML
P
DN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
GS
PR
L
ERY
N
GI
P
SME
I
LG
EA
AAGK
S
T
G
D
A
MKFMADLVAK
L
-
-
P
A
G
VGYS
W
T
G
--
LS
YQ
EA
L
SSNQAPA
L
Y
A
-
I
S
L
V
V
VFL
A
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LS
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
VEMM
Q
KE
----------
G
KTPI
EA
IIE
A
ARM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
VI
S
H
GAGSG
AQNA
VG
T
GVMGGM
FA
A
T
V
LAI
Y
fig|316401.4.peg.4264
Escherichia coli ETEC H10407 (16-1018/1037)
AI
I
M
M
L
A
G
GLA
I
MN
LPV
A
QYP
Q
I
AP
P
T
I
T
V
S
A
T
YPGA
D
AQ
T
V
E
D
S
VT
Q
VIE
QN
M
NG
L
D
GLM
Y
MSS
T
S
DAA
G
NAS
ITL
T
FE
T
GT
S
PD
I
A
QV
QVQ
NK
LQ
L
A
MPS
LP
EAVQQQ
G
I
SVD-KSSSN
---
I
L
MVA
A
FI
S
DNGSLNQY
DI
A
D
Y
V
ASN
I
KDP
LS
RTA
GVG
S
V
QLF
G
SEY-AM
RI
W
LDP
QK
LN
KYN
L
VPSD
V
IS
Q
I
KVQ
N
NQISG
GQLGG
M
P
QAADQQLNAS
I
I
V
QTR
LQT
P
EEF
GK
I
L
L
KVQQ
DG
SQ
V
L
L
R
DVA
R
VE
L
G
A
E
DYSTV
A
RY
NGK
-
P
A
A
G
IA
I
K
L
AA
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAY
FP
A
S
L
K
TVYP
YDTT
PF
I
EI
SI
Q
E
VFKT
L
V
EAI
I
LV
F
LV
M
YLFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
A
I
L
S
A
V
G
F
T
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
D
KLP
P
KE
A
TH
K
SMG
QIQ
R
AL
VGIAVV
L
S
AVF
M
PM
A
F
MS
G
AT
G
E
IYR
Q
FSIT
LIS
S
M
LL
SV
F
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARF
N
TL
F
EKSTQH
----
Y
TDSTR
S
L
L
RCTGRY
M
V
VY
L
L
ICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
L
P
S
G
A
T
MVNTTKVLQ
Q
VT
DYY
LTKEKDN
V
Q
SVF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVT
AII
Q
RA
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AEL
G
TA
S
GFDME
L
LDNGNLGH
E
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
TG
V
RP
N
G
LE
DTPMFK
VNV
N
AA
KA
E
A
M
GV
A
L
S
DI
NQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
ML
P
DN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
GS
PR
L
ERY
N
GI
P
SME
I
LG
EA
AAGK
S
T
G
D
A
MKFMADLVAK
L
-
-
P
A
G
VGYS
W
T
G
--
LS
YQ
EA
L
SSNQAPA
L
Y
A
-
I
S
L
V
V
VFL
A
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LS
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
VEMM
Q
KE
----------
G
KTPI
EA
IIE
A
ARM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
VI
S
H
GAGSG
AQNA
VG
T
GVMGGM
FA
A
T
V
LAI
Y
fig|656414.3.peg.4012
Escherichia coli H736 (16-1018/1037)
AI
I
M
M
L
A
G
GLA
I
MN
LPV
A
QYP
Q
I
AP
P
T
I
T
V
S
A
T
YPGA
D
AQ
T
V
E
D
S
VT
Q
VIE
QN
M
NG
L
D
GLM
Y
MSS
T
S
DAA
G
NAS
ITL
T
FE
T
GT
S
PD
I
A
QV
QVQ
NK
LQ
L
A
MPS
LP
EAVQQQ
G
I
SVD-KSSSN
---
I
L
MVA
A
FI
S
DNGSLNQY
DI
A
D
Y
V
ASN
I
KDP
LS
RTA
GVG
S
V
QLF
G
SEY-AM
RI
W
LDP
QK
LN
KYN
L
VPSD
V
IS
Q
I
KVQ
N
NQISG
GQLGG
M
P
QAADQQLNAS
I
I
V
QTR
LQT
P
EEF
GK
I
L
L
KVQQ
DG
SQ
V
L
L
R
DVA
R
VE
L
G
A
E
DYSTV
A
RY
NGK
-
P
A
A
G
IA
I
K
L
AA
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAY
FP
A
S
L
K
TVYP
YDTT
PF
I
EI
SI
Q
E
VFKT
L
V
EAI
I
LV
F
LV
M
YLFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
A
I
L
S
A
V
G
F
T
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
D
KLP
P
KE
A
TH
K
SMG
QIQ
R
AL
VGIAVV
L
S
AVF
M
PM
A
F
MS
G
AT
G
E
IYR
Q
FSIT
LIS
S
M
LL
SV
F
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARF
N
TL
F
EKSTQH
----
Y
TDSTR
S
L
L
RCTGRY
M
V
VY
L
L
ICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
L
P
S
G
A
T
MVNTTKVLQ
Q
VT
DYY
LTKEKDN
V
Q
SVF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVT
AII
Q
RA
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AEL
G
TA
S
GFDME
L
LDNGNLGH
E
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
TG
V
RP
N
G
LE
DTPMFK
VNV
N
AA
KA
E
A
M
GV
A
L
S
DI
NQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
ML
P
DN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
GS
PR
L
ERY
N
GI
P
SME
I
LG
EA
AAGK
S
T
G
D
A
MKFMADLVAK
L
-
-
P
A
G
VGYS
W
T
G
--
LS
YQ
EA
L
SSNQAPA
L
Y
A
-
I
S
L
V
V
VFL
A
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LS
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
VEMM
Q
KE
----------
G
KTPI
EA
IIE
A
ARM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
VI
S
H
GAGSG
AQNA
VG
T
GVMGGM
FA
A
T
V
LAI
Y
fig|331112.3.peg.3483
Escherichia coli HS (16-1018/1037)
AI
I
M
M
L
A
G
GLA
I
MN
LPV
A
QYP
Q
I
AP
P
T
I
T
V
S
A
T
YPGA
D
AQ
T
V
E
D
S
VT
Q
VIE
QN
M
NG
L
D
GLM
Y
MSS
T
S
DAA
G
NAS
ITL
T
FE
T
GT
S
PD
I
A
QV
QVQ
NK
LQ
L
A
MPS
LP
EAVQQQ
G
I
SVD-KSSSN
---
I
L
MVA
A
FI
S
DNGSLNQY
DI
A
D
Y
V
ASN
I
KDP
LS
RTA
GVG
S
V
QLF
G
SEY-AM
RI
W
LDP
QK
LN
KYN
L
VPSD
V
IS
Q
I
KVQ
N
NQISG
GQLGG
M
P
QAADQQLNAS
I
I
V
QTR
LQT
P
EEF
GK
I
L
L
KVQQ
DG
SQ
V
L
L
R
DVA
R
VE
L
G
A
E
DYSTV
A
RY
NGK
-
P
A
A
G
IA
I
K
L
AA
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAY
FP
A
S
L
K
TVYP
YDTT
PF
I
EI
SI
Q
E
VFKT
L
V
EAI
I
LV
F
LV
M
YLFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
A
I
L
S
A
V
G
F
T
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
D
KLP
P
KE
A
TH
K
SMG
QIQ
R
AL
VGIAVV
L
S
AVF
M
PM
A
F
MS
G
AT
G
E
IYR
Q
FSIT
LIS
S
M
LL
SV
F
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARF
N
TL
F
EKSTQH
----
Y
TDSTR
S
L
L
RCTGRY
M
V
VY
L
L
ICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
L
P
S
G
A
T
MVNTTKVLQ
Q
VT
DYY
LTKEKDN
V
Q
SVF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVT
AII
Q
RA
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AEL
G
TA
S
GFDME
L
LDNGNLGH
E
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
TG
V
RP
N
G
LE
DTPMFK
VNV
N
AA
KA
E
A
M
GV
A
L
S
DI
NQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
ML
P
DN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
GS
PR
L
ERY
N
GI
P
SME
I
LG
EA
AAGK
S
T
G
D
A
MKFMADLVAK
L
-
-
P
A
G
VGYS
W
T
G
--
LS
YQ
EA
L
SSNQAPA
L
Y
A
-
I
S
L
V
V
VFL
A
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LS
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
VEMM
Q
KE
----------
G
KTPI
EA
IIE
A
ARM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
VI
S
H
GAGSG
AQNA
VG
T
GVMGGM
FA
A
T
V
LAI
Y
fig|331112.6.peg.3625
Escherichia coli HS (16-1018/1037)
AI
I
M
M
L
A
G
GLA
I
MN
LPV
A
QYP
Q
I
AP
P
T
I
T
V
S
A
T
YPGA
D
AQ
T
V
E
D
S
VT
Q
VIE
QN
M
NG
L
D
GLM
Y
MSS
T
S
DAA
G
NAS
ITL
T
FE
T
GT
S
PD
I
A
QV
QVQ
NK
LQ
L
A
MPS
LP
EAVQQQ
G
I
SVD-KSSSN
---
I
L
MVA
A
FI
S
DNGSLNQY
DI
A
D
Y
V
ASN
I
KDP
LS
RTA
GVG
S
V
QLF
G
SEY-AM
RI
W
LDP
QK
LN
KYN
L
VPSD
V
IS
Q
I
KVQ
N
NQISG
GQLGG
M
P
QAADQQLNAS
I
I
V
QTR
LQT
P
EEF
GK
I
L
L
KVQQ
DG
SQ
V
L
L
R
DVA
R
VE
L
G
A
E
DYSTV
A
RY
NGK
-
P
A
A
G
IA
I
K
L
AA
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAY
FP
A
S
L
K
TVYP
YDTT
PF
I
EI
SI
Q
E
VFKT
L
V
EAI
I
LV
F
LV
M
YLFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
A
I
L
S
A
V
G
F
T
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
D
KLP
P
KE
A
TH
K
SMG
QIQ
R
AL
VGIAVV
L
S
AVF
M
PM
A
F
MS
G
AT
G
E
IYR
Q
FSIT
LIS
S
M
LL
SV
F
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARF
N
TL
F
EKSTQH
----
Y
TDSTR
S
L
L
RCTGRY
M
V
VY
L
L
ICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
L
P
S
G
A
T
MVNTTKVLQ
Q
VT
DYY
LTKEKDN
V
Q
SVF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVT
AII
Q
RA
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AEL
G
TA
S
GFDME
L
LDNGNLGH
E
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
TG
V
RP
N
G
LE
DTPMFK
VNV
N
AA
KA
E
A
M
GV
A
L
S
DI
NQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
ML
P
DN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
GS
PR
L
ERY
N
GI
P
SME
I
LG
EA
AAGK
S
T
G
D
A
MKFMADLVAK
L
-
-
P
A
G
VGYS
W
T
G
--
LS
YQ
EA
L
SSNQAPA
L
Y
A
-
I
S
L
V
V
VFL
A
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LS
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
VEMM
Q
KE
----------
G
KTPI
EA
IIE
A
ARM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
VI
S
H
GAGSG
AQNA
VG
T
GVMGGM
FA
A
T
V
LAI
Y
fig|83333.1.peg.3447
Escherichia coli K12 (16-1018/1037)
AI
I
M
M
L
A
G
GLA
I
MN
LPV
A
QYP
Q
I
AP
P
T
I
T
V
S
A
T
YPGA
D
AQ
T
V
E
D
S
VT
Q
VIE
QN
M
NG
L
D
GLM
Y
MSS
T
S
DAA
G
NAS
ITL
T
FE
T
GT
S
PD
I
A
QV
QVQ
NK
LQ
L
A
MPS
LP
EAVQQQ
G
I
SVD-KSSSN
---
I
L
MVA
A
FI
S
DNGSLNQY
DI
A
D
Y
V
ASN
I
KDP
LS
RTA
GVG
S
V
QLF
G
SEY-AM
RI
W
LDP
QK
LN
KYN
L
VPSD
V
IS
Q
I
KVQ
N
NQISG
GQLGG
M
P
QAADQQLNAS
I
I
V
QTR
LQT
P
EEF
GK
I
L
L
KVQQ
DG
SQ
V
L
L
R
DVA
R
VE
L
G
A
E
DYSTV
A
RY
NGK
-
P
A
A
G
IA
I
K
L
AA
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAY
FP
A
S
L
K
TVYP
YDTT
PF
I
EI
SI
Q
E
VFKT
L
V
EAI
I
LV
F
LV
M
YLFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
A
I
L
S
A
V
G
F
T
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
D
KLP
P
KE
A
TH
K
SMG
QIQ
R
AL
VGIAVV
L
S
AVF
M
PM
A
F
MS
G
AT
G
E
IYR
Q
FSIT
LIS
S
M
LL
SV
F
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARF
N
TL
F
EKSTQH
----
Y
TDSTR
S
L
L
RCTGRY
M
V
VY
L
L
ICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
L
P
S
G
A
T
MVNTTKVLQ
Q
VT
DYY
LTKEKDN
V
Q
SVF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVT
AII
Q
RA
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AEL
G
TA
S
GFDME
L
LDNGNLGH
E
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
TG
V
RP
N
G
LE
DTPMFK
VNV
N
AA
KA
E
A
M
GV
A
L
S
DI
NQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
ML
P
DN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
GS
PR
L
ERY
N
GI
P
SME
I
LG
EA
AAGK
S
T
G
D
A
MKFMADLVAK
L
-
-
P
A
G
VGYS
W
T
G
--
LS
YQ
EA
L
SSNQAPA
L
Y
A
-
I
S
L
V
V
VFL
A
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LS
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
VEMM
Q
KE
----------
G
KTPI
EA
IIE
A
ARM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
VI
S
H
GAGSG
AQNA
VG
T
GVMGGM
FA
A
T
V
LAI
Y
fig|749538.3.peg.4048
Escherichia coli MS 116-1 (16-1018/1037)
AI
I
M
M
L
A
G
GLA
I
MN
LPV
A
QYP
Q
I
AP
P
T
I
T
V
S
A
T
YPGA
D
AQ
T
V
E
D
S
VT
Q
VIE
QN
M
NG
L
D
GLM
Y
MSS
T
S
DAA
G
NAS
ITL
T
FE
T
GT
S
PD
I
A
QV
QVQ
NK
LQ
L
A
MPS
LP
EAVQQQ
G
I
SVD-KSSSN
---
I
L
MVA
A
FI
S
DNGSLNQY
DI
A
D
Y
V
ASN
I
KDP
LS
RTA
GVG
S
V
QLF
G
SEY-AM
RI
W
LDP
QK
LN
KYN
L
VPSD
V
IS
Q
I
KVQ
N
NQISG
GQLGG
M
P
QAADQQLNAS
I
I
V
QTR
LQT
P
EEF
GK
I
L
L
KVQQ
DG
SQ
V
L
L
R
DVA
R
VE
L
G
A
E
DYSTV
A
RY
NGK
-
P
A
A
G
IA
I
K
L
AA
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAY
FP
A
S
L
K
TVYP
YDTT
PF
I
EI
SI
Q
E
VFKT
L
V
EAI
I
LV
F
LV
M
YLFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
A
I
L
S
A
V
G
F
T
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
D
KLP
P
KE
A
TH
K
SMG
QIQ
R
AL
VGIAVV
L
S
AVF
M
PM
A
F
MS
G
AT
G
E
IYR
Q
FSIT
LIS
S
M
LL
SV
F
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARF
N
TL
F
EKSTQH
----
Y
TDSTR
S
L
L
RCTGRY
M
V
VY
L
L
ICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
L
P
S
G
A
T
MVNTTKVLQ
Q
VT
DYY
LTKEKDN
V
Q
SVF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVT
AII
Q
RA
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AEL
G
TA
S
GFDME
L
LDNGNLGH
E
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
TG
V
RP
N
G
LE
DTPMFK
VNV
N
AA
KA
E
A
M
GV
A
L
S
DI
NQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
ML
P
DN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
GS
PR
L
ERY
N
GI
P
SME
I
LG
EA
AAGK
S
T
G
D
A
MKFMADLVAK
L
-
-
P
A
G
VGYS
W
T
G
--
LS
YQ
EA
L
SSNQAPA
L
Y
A
-
I
S
L
V
V
VFL
A
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LS
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
VEMM
Q
KE
----------
G
KTPI
EA
IIE
A
ARM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
VI
S
H
GAGSG
AQNA
VG
T
GVMGGM
FA
A
T
V
LAI
Y
fig|749540.3.peg.2558
Escherichia coli MS 146-1 (16-1018/1037)
AI
I
M
M
L
A
G
GLA
I
MN
LPV
A
QYP
Q
I
AP
P
T
I
T
V
S
A
T
YPGA
D
AQ
T
V
E
D
S
VT
Q
VIE
QN
M
NG
L
D
GLM
Y
MSS
T
S
DAA
G
NAS
ITL
T
FE
T
GT
S
PD
I
A
QV
QVQ
NK
LQ
L
A
MPS
LP
EAVQQQ
G
I
SVD-KSSSN
---
I
L
MVA
A
FI
S
DNGSLNQY
DI
A
D
Y
V
ASN
I
KDP
LS
RTA
GVG
S
V
QLF
G
SEY-AM
RI
W
LDP
QK
LN
KYN
L
VPSD
V
IS
Q
I
KVQ
N
NQISG
GQLGG
M
P
QAADQQLNAS
I
I
V
QTR
LQT
P
EEF
GK
I
L
L
KVQQ
DG
SQ
V
L
L
R
DVA
R
VE
L
G
A
E
DYSTV
A
RY
NGK
-
P
A
A
G
IA
I
K
L
AA
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAY
FP
A
S
L
K
TVYP
YDTT
PF
I
EI
SI
Q
E
VFKT
L
V
EAI
I
LV
F
LV
M
YLFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
A
I
L
S
A
V
G
F
T
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
D
KLP
P
KE
A
TH
K
SMG
QIQ
R
AL
VGIAVV
L
S
AVF
M
PM
A
F
MS
G
AT
G
E
IYR
Q
FSIT
LIS
S
M
LL
SV
F
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARF
N
TL
F
EKSTQH
----
Y
TDSTR
S
L
L
RCTGRY
M
V
VY
L
L
ICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
L
P
S
G
A
T
MVNTTKVLQ
Q
VT
DYY
LTKEKDN
V
Q
SVF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVT
AII
Q
RA
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AEL
G
TA
S
GFDME
L
LDNGNLGH
E
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
TG
V
RP
N
G
LE
DTPMFK
VNV
N
AA
KA
E
A
M
GV
A
L
S
DI
NQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
ML
P
DN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
GS
PR
L
ERY
N
GI
P
SME
I
LG
EA
AAGK
S
T
G
D
A
MKFMADLVAK
L
-
-
P
A
G
VGYS
W
T
G
--
LS
YQ
EA
L
SSNQAPA
L
Y
A
-
I
S
L
V
V
VFL
A
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LS
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
VEMM
Q
KE
----------
G
KTPI
EA
IIE
A
ARM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
VI
S
H
GAGSG
AQNA
VG
T
GVMGGM
FA
A
T
V
LAI
Y
fig|749544.3.peg.2968
Escherichia coli MS 175-1 (16-1018/1037)
AI
I
M
M
L
A
G
GLA
I
MN
LPV
A
QYP
Q
I
AP
P
T
I
T
V
S
A
T
YPGA
D
AQ
T
V
E
D
S
VT
Q
VIE
QN
M
NG
L
D
GLM
Y
MSS
T
S
DAA
G
NAS
ITL
T
FE
T
GT
S
PD
I
A
QV
QVQ
NK
LQ
L
A
MPS
LP
EAVQQQ
G
I
SVD-KSSSN
---
I
L
MVA
A
FI
S
DNGSLNQY
DI
A
D
Y
V
ASN
I
KDP
LS
RTA
GVG
S
V
QLF
G
SEY-AM
RI
W
LDP
QK
LN
KYN
L
VPSD
V
IS
Q
I
KVQ
N
NQISG
GQLGG
M
P
QAADQQLNAS
I
I
V
QTR
LQT
P
EEF
GK
I
L
L
KVQQ
DG
SQ
V
L
L
R
DVA
R
VE
L
G
A
E
DYSTV
A
RY
NGK
-
P
A
A
G
IA
I
K
L
AA
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAY
FP
A
S
L
K
TVYP
YDTT
PF
I
EI
SI
Q
E
VFKT
L
V
EAI
I
LV
F
LV
M
YLFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
A
I
L
S
A
V
G
F
T
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
D
KLP
P
KE
A
TH
K
SMG
QIQ
R
AL
VGIAVV
L
S
AVF
M
PM
A
F
MS
G
AT
G
E
IYR
Q
FSIT
LIS
S
M
LL
SV
F
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARF
N
TL
F
EKSTQH
----
Y
TDSTR
S
L
L
RCTGRY
M
V
VY
L
L
ICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
L
P
S
G
A
T
MVNTTKVLQ
Q
VT
DYY
LTKEKDN
V
Q
SVF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVT
AII
Q
RA
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AEL
G
TA
S
GFDME
L
LDNGNLGH
E
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
TG
V
RP
N
G
LE
DTPMFK
VNV
N
AA
KA
E
A
M
GV
A
L
S
DI
NQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
ML
P
DN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
GS
PR
L
ERY
N
GI
P
SME
I
LG
EA
AAGK
S
T
G
D
A
MKFMADLVAK
L
-
-
P
A
G
VGYS
W
T
G
--
LS
YQ
EA
L
SSNQAPA
L
Y
A
-
I
S
L
V
V
VFL
A
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LS
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
VEMM
Q
KE
----------
G
KTPI
EA
IIE
A
ARM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
VI
S
H
GAGSG
AQNA
VG
T
GVMGGM
FA
A
T
V
LAI
Y
fig|316407.3.peg.3615
Escherichia coli W3110 (16-1018/1037)
AI
I
M
M
L
A
G
GLA
I
MN
LPV
A
QYP
Q
I
AP
P
T
I
T
V
S
A
T
YPGA
D
AQ
T
V
E
D
S
VT
Q
VIE
QN
M
NG
L
D
GLM
Y
MSS
T
S
DAA
G
NAS
ITL
T
FE
T
GT
S
PD
I
A
QV
QVQ
NK
LQ
L
A
MPS
LP
EAVQQQ
G
I
SVD-KSSSN
---
I
L
MVA
A
FI
S
DNGSLNQY
DI
A
D
Y
V
ASN
I
KDP
LS
RTA
GVG
S
V
QLF
G
SEY-AM
RI
W
LDP
QK
LN
KYN
L
VPSD
V
IS
Q
I
KVQ
N
NQISG
GQLGG
M
P
QAADQQLNAS
I
I
V
QTR
LQT
P
EEF
GK
I
L
L
KVQQ
DG
SQ
V
L
L
R
DVA
R
VE
L
G
A
E
DYSTV
A
RY
NGK
-
P
A
A
G
IA
I
K
L
AA
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAY
FP
A
S
L
K
TVYP
YDTT
PF
I
EI
SI
Q
E
VFKT
L
V
EAI
I
LV
F
LV
M
YLFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
A
I
L
S
A
V
G
F
T
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
D
KLP
P
KE
A
TH
K
SMG
QIQ
R
AL
VGIAVV
L
S
AVF
M
PM
A
F
MS
G
AT
G
E
IYR
Q
FSIT
LIS
S
M
LL
SV
F
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARF
N
TL
F
EKSTQH
----
Y
TDSTR
S
L
L
RCTGRY
M
V
VY
L
L
ICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
L
P
S
G
A
T
MVNTTKVLQ
Q
VT
DYY
LTKEKDN
V
Q
SVF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVT
AII
Q
RA
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AEL
G
TA
S
GFDME
L
LDNGNLGH
E
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
TG
V
RP
N
G
LE
DTPMFK
VNV
N
AA
KA
E
A
M
GV
A
L
S
DI
NQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
ML
P
DN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
GS
PR
L
ERY
N
GI
P
SME
I
LG
EA
AAGK
S
T
G
D
A
MKFMADLVAK
L
-
-
P
A
G
VGYS
W
T
G
--
LS
YQ
EA
L
SSNQAPA
L
Y
A
-
I
S
L
V
V
VFL
A
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LS
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
VEMM
Q
KE
----------
G
KTPI
EA
IIE
A
ARM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
VI
S
H
GAGSG
AQNA
VG
T
GVMGGM
FA
A
T
V
LAI
Y
fig|316385.5.peg.3639
Escherichia coli str. K-12 substr. DH10B (16-1018/1037)
AI
I
M
M
L
A
G
GLA
I
MN
LPV
A
QYP
Q
I
AP
P
T
I
T
V
S
A
T
YPGA
D
AQ
T
V
E
D
S
VT
Q
VIE
QN
M
NG
L
D
GLM
Y
MSS
T
S
DAA
G
NAS
ITL
T
FE
T
GT
S
PD
I
A
QV
QVQ
NK
LQ
L
A
MPS
LP
EAVQQQ
G
I
SVD-KSSSN
---
I
L
MVA
A
FI
S
DNGSLNQY
DI
A
D
Y
V
ASN
I
KDP
LS
RTA
GVG
S
V
QLF
G
SEY-AM
RI
W
LDP
QK
LN
KYN
L
VPSD
V
IS
Q
I
KVQ
N
NQISG
GQLGG
M
P
QAADQQLNAS
I
I
V
QTR
LQT
P
EEF
GK
I
L
L
KVQQ
DG
SQ
V
L
L
R
DVA
R
VE
L
G
A
E
DYSTV
A
RY
NGK
-
P
A
A
G
IA
I
K
L
AA
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAY
FP
A
S
L
K
TVYP
YDTT
PF
I
EI
SI
Q
E
VFKT
L
V
EAI
I
LV
F
LV
M
YLFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
A
I
L
S
A
V
G
F
T
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
D
KLP
P
KE
A
TH
K
SMG
QIQ
R
AL
VGIAVV
L
S
AVF
M
PM
A
F
MS
G
AT
G
E
IYR
Q
FSIT
LIS
S
M
LL
SV
F
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARF
N
TL
F
EKSTQH
----
Y
TDSTR
S
L
L
RCTGRY
M
V
VY
L
L
ICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
L
P
S
G
A
T
MVNTTKVLQ
Q
VT
DYY
LTKEKDN
V
Q
SVF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVT
AII
Q
RA
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AEL
G
TA
S
GFDME
L
LDNGNLGH
E
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
TG
V
RP
N
G
LE
DTPMFK
VNV
N
AA
KA
E
A
M
GV
A
L
S
DI
NQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
ML
P
DN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
GS
PR
L
ERY
N
GI
P
SME
I
LG
EA
AAGK
S
T
G
D
A
MKFMADLVAK
L
-
-
P
A
G
VGYS
W
T
G
--
LS
YQ
EA
L
SSNQAPA
L
Y
A
-
I
S
L
V
V
VFL
A
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LS
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
VEMM
Q
KE
----------
G
KTPI
EA
IIE
A
ARM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
VI
S
H
GAGSG
AQNA
VG
T
GVMGGM
FA
A
T
V
LAI
Y
fig|316385.7.peg.3723
Escherichia coli str. K-12 substr. DH10B (16-1018/1037)
AI
I
M
M
L
A
G
GLA
I
MN
LPV
A
QYP
Q
I
AP
P
T
I
T
V
S
A
T
YPGA
D
AQ
T
V
E
D
S
VT
Q
VIE
QN
M
NG
L
D
GLM
Y
MSS
T
S
DAA
G
NAS
ITL
T
FE
T
GT
S
PD
I
A
QV
QVQ
NK
LQ
L
A
MPS
LP
EAVQQQ
G
I
SVD-KSSSN
---
I
L
MVA
A
FI
S
DNGSLNQY
DI
A
D
Y
V
ASN
I
KDP
LS
RTA
GVG
S
V
QLF
G
SEY-AM
RI
W
LDP
QK
LN
KYN
L
VPSD
V
IS
Q
I
KVQ
N
NQISG
GQLGG
M
P
QAADQQLNAS
I
I
V
QTR
LQT
P
EEF
GK
I
L
L
KVQQ
DG
SQ
V
L
L
R
DVA
R
VE
L
G
A
E
DYSTV
A
RY
NGK
-
P
A
A
G
IA
I
K
L
AA
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAY
FP
A
S
L
K
TVYP
YDTT
PF
I
EI
SI
Q
E
VFKT
L
V
EAI
I
LV
F
LV
M
YLFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
A
I
L
S
A
V
G
F
T
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
D
KLP
P
KE
A
TH
K
SMG
QIQ
R
AL
VGIAVV
L
S
AVF
M
PM
A
F
MS
G
AT
G
E
IYR
Q
FSIT
LIS
S
M
LL
SV
F
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARF
N
TL
F
EKSTQH
----
Y
TDSTR
S
L
L
RCTGRY
M
V
VY
L
L
ICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
L
P
S
G
A
T
MVNTTKVLQ
Q
VT
DYY
LTKEKDN
V
Q
SVF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVT
AII
Q
RA
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AEL
G
TA
S
GFDME
L
LDNGNLGH
E
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
TG
V
RP
N
G
LE
DTPMFK
VNV
N
AA
KA
E
A
M
GV
A
L
S
DI
NQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
ML
P
DN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
GS
PR
L
ERY
N
GI
P
SME
I
LG
EA
AAGK
S
T
G
D
A
MKFMADLVAK
L
-
-
P
A
G
VGYS
W
T
G
--
LS
YQ
EA
L
SSNQAPA
L
Y
A
-
I
S
L
V
V
VFL
A
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LS
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
VEMM
Q
KE
----------
G
KTPI
EA
IIE
A
ARM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
VI
S
H
GAGSG
AQNA
VG
T
GVMGGM
FA
A
T
V
LAI
Y
fig|511145.12.peg.3622
Escherichia coli str. K-12 substr. MG1655 (16-1018/1037)
AI
I
M
M
L
A
G
GLA
I
MN
LPV
A
QYP
Q
I
AP
P
T
I
T
V
S
A
T
YPGA
D
AQ
T
V
E
D
S
VT
Q
VIE
QN
M
NG
L
D
GLM
Y
MSS
T
S
DAA
G
NAS
ITL
T
FE
T
GT
S
PD
I
A
QV
QVQ
NK
LQ
L
A
MPS
LP
EAVQQQ
G
I
SVD-KSSSN
---
I
L
MVA
A
FI
S
DNGSLNQY
DI
A
D
Y
V
ASN
I
KDP
LS
RTA
GVG
S
V
QLF
G
SEY-AM
RI
W
LDP
QK
LN
KYN
L
VPSD
V
IS
Q
I
KVQ
N
NQISG
GQLGG
M
P
QAADQQLNAS
I
I
V
QTR
LQT
P
EEF
GK
I
L
L
KVQQ
DG
SQ
V
L
L
R
DVA
R
VE
L
G
A
E
DYSTV
A
RY
NGK
-
P
A
A
G
IA
I
K
L
AA
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAY
FP
A
S
L
K
TVYP
YDTT
PF
I
EI
SI
Q
E
VFKT
L
V
EAI
I
LV
F
LV
M
YLFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
A
I
L
S
A
V
G
F
T
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
D
KLP
P
KE
A
TH
K
SMG
QIQ
R
AL
VGIAVV
L
S
AVF
M
PM
A
F
MS
G
AT
G
E
IYR
Q
FSIT
LIS
S
M
LL
SV
F
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARF
N
TL
F
EKSTQH
----
Y
TDSTR
S
L
L
RCTGRY
M
V
VY
L
L
ICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
L
P
S
G
A
T
MVNTTKVLQ
Q
VT
DYY
LTKEKDN
V
Q
SVF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVT
AII
Q
RA
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AEL
G
TA
S
GFDME
L
LDNGNLGH
E
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
TG
V
RP
N
G
LE
DTPMFK
VNV
N
AA
KA
E
A
M
GV
A
L
S
DI
NQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
ML
P
DN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
GS
PR
L
ERY
N
GI
P
SME
I
LG
EA
AAGK
S
T
G
D
A
MKFMADLVAK
L
-
-
P
A
G
VGYS
W
T
G
--
LS
YQ
EA
L
SSNQAPA
L
Y
A
-
I
S
L
V
V
VFL
A
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LS
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
VEMM
Q
KE
----------
G
KTPI
EA
IIE
A
ARM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
VI
S
H
GAGSG
AQNA
VG
T
GVMGGM
FA
A
T
V
LAI
Y
fig|511145.6.peg.3604
Escherichia coli str. K-12 substr. MG1655 (16-1018/1037)
AI
I
M
M
L
A
G
GLA
I
MN
LPV
A
QYP
Q
I
AP
P
T
I
T
V
S
A
T
YPGA
D
AQ
T
V
E
D
S
VT
Q
VIE
QN
M
NG
L
D
GLM
Y
MSS
T
S
DAA
G
NAS
ITL
T
FE
T
GT
S
PD
I
A
QV
QVQ
NK
LQ
L
A
MPS
LP
EAVQQQ
G
I
SVD-KSSSN
---
I
L
MVA
A
FI
S
DNGSLNQY
DI
A
D
Y
V
ASN
I
KDP
LS
RTA
GVG
S
V
QLF
G
SEY-AM
RI
W
LDP
QK
LN
KYN
L
VPSD
V
IS
Q
I
KVQ
N
NQISG
GQLGG
M
P
QAADQQLNAS
I
I
V
QTR
LQT
P
EEF
GK
I
L
L
KVQQ
DG
SQ
V
L
L
R
DVA
R
VE
L
G
A
E
DYSTV
A
RY
NGK
-
P
A
A
G
IA
I
K
L
AA
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAY
FP
A
S
L
K
TVYP
YDTT
PF
I
EI
SI
Q
E
VFKT
L
V
EAI
I
LV
F
LV
M
YLFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
A
I
L
S
A
V
G
F
T
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
D
KLP
P
KE
A
TH
K
SMG
QIQ
R
AL
VGIAVV
L
S
AVF
M
PM
A
F
MS
G
AT
G
E
IYR
Q
FSIT
LIS
S
M
LL
SV
F
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARF
N
TL
F
EKSTQH
----
Y
TDSTR
S
L
L
RCTGRY
M
V
VY
L
L
ICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
L
P
S
G
A
T
MVNTTKVLQ
Q
VT
DYY
LTKEKDN
V
Q
SVF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVT
AII
Q
RA
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AEL
G
TA
S
GFDME
L
LDNGNLGH
E
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
TG
V
RP
N
G
LE
DTPMFK
VNV
N
AA
KA
E
A
M
GV
A
L
S
DI
NQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
ML
P
DN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
GS
PR
L
ERY
N
GI
P
SME
I
LG
EA
AAGK
S
T
G
D
A
MKFMADLVAK
L
-
-
P
A
G
VGYS
W
T
G
--
LS
YQ
EA
L
SSNQAPA
L
Y
A
-
I
S
L
V
V
VFL
A
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LS
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
VEMM
Q
KE
----------
G
KTPI
EA
IIE
A
ARM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
VI
S
H
GAGSG
AQNA
VG
T
GVMGGM
FA
A
T
V
LAI
Y
fig|439855.10.peg.3963
Escherichia coli SMS-3-5 (16-1018/1037)
AI
I
M
M
L
A
G
GLA
I
MN
LPV
A
QYP
Q
I
AP
P
T
I
T
I
S
A
T
YPGA
D
AQ
T
V
E
D
S
VT
Q
VIE
QN
M
NG
L
D
GLM
Y
MSS
T
S
DAA
G
NAS
ITL
T
FE
T
GT
S
PD
I
A
QV
QVQ
NK
LQ
L
A
MPS
LP
EAVQQQ
G
I
SVD-KSSSN
---
I
L
MVA
A
FI
S
DNGSLNQY
DI
A
D
Y
V
ASN
I
KDP
LS
RTA
GVG
S
V
QLF
G
SEY-AM
RI
W
LDP
QK
LN
KYN
L
VPSD
V
IS
Q
I
KVQ
N
NQISG
GQLGG
M
P
QAADQQLNAS
I
I
V
QTR
LQT
P
EEF
GK
I
L
L
KVQQ
DG
SQ
V
L
L
R
DVA
R
VE
L
G
A
E
DYSTV
A
RY
NGK
-
P
A
A
G
IA
I
K
L
AT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAY
FP
A
S
L
K
TVYP
YDTT
PF
I
KI
SI
Q
E
VFKT
L
V
EAI
I
LV
F
LV
M
YLFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
A
I
L
S
A
V
G
F
T
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
D
KLP
P
KE
A
TH
K
SMR
QIQ
R
AL
VGIAVV
L
S
AVF
M
PM
A
F
MS
G
AT
G
E
IYR
Q
FSIT
LIS
S
M
LL
SV
F
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARF
N
TL
F
EKSTQH
----
Y
TDSTR
S
L
L
RCTGRY
M
V
VY
L
L
ICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
L
P
S
G
A
T
MVNTTKVLQ
Q
VT
DYY
LTKEKDN
V
Q
SVF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVT
AII
Q
RA
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AEL
G
TA
S
GFDME
L
LDNGNLGH
E
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
TG
V
RP
N
G
LE
DTPMFK
VNV
N
AA
KA
E
A
M
GV
A
L
S
DI
NQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
ML
P
DN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
GS
PR
L
ERY
N
GI
P
SME
I
LG
EA
AAGK
S
T
G
D
A
MKFMADLVAK
L
-
-
P
A
G
VGYS
W
T
G
--
LS
YQ
EA
L
SSNQAPA
L
Y
A
-
I
S
L
V
V
VFL
A
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LS
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
VEMM
Q
KE
----------
G
KTPI
EA
IIE
A
ARM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
VI
S
H
GAGSG
AQNA
VG
T
GVMGGM
FA
A
T
V
LAI
Y
fig|362663.8.peg.3645
Escherichia coli 536 (16-1018/1037)
AI
I
M
M
L
A
G
GLA
I
MN
LPV
A
QYP
Q
I
AP
P
T
I
T
I
S
A
T
YPGA
D
AQ
T
V
E
D
S
VT
Q
VIE
QN
M
NG
L
D
GLM
Y
MSS
T
S
DAA
G
NAS
ITL
T
FE
T
GT
S
PD
I
A
QV
QVQ
NK
LQ
L
A
MPS
LP
EAVQQQ
G
I
SVD-KSSSN
---
I
L
MVA
A
FI
S
DNGSLNQY
DI
A
D
Y
V
ASN
I
KDP
LS
RTA
GVG
S
V
QLF
G
SEY-AM
RI
W
LDP
QK
LN
KYN
L
VPSD
V
IS
Q
I
KVQ
N
NQISG
GQLGG
M
P
QAADQQLNAS
I
I
V
QTR
LQT
P
EEF
GK
I
L
L
KVQQ
DG
SQ
V
L
L
R
DVA
R
VE
L
G
A
E
DYSTV
A
RY
NGK
-
P
A
A
G
IA
I
K
L
AT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAY
FP
A
S
L
K
TVYP
YDTT
PF
I
KI
SI
Q
E
VFKT
L
V
EAI
I
LV
F
LV
M
YLFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
A
I
L
S
A
V
G
F
T
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
D
KLP
P
KE
A
TH
K
SMG
QIQ
R
AL
VGIAVV
L
S
AVF
M
PM
A
F
MS
G
AT
G
E
IYR
Q
FSIT
LIS
S
M
LL
SV
F
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNTLFARF
N
TL
F
EKSTQH
----
Y
TDSTR
S
L
L
RCTGRY
M
V
VY
L
L
ICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
L
P
S
G
A
T
MVNTTKVLQ
Q
VT
DYY
LTKEKNN
V
Q
SVF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVT
AII
Q
RA
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AEL
G
TA
S
GFDME
L
LDNGNLGH
E
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
IG
V
RP
N
G
LE
DTPMFK
VNV
N
AA
KA
E
A
M
GV
A
L
S
DI
NQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
ML
P
DN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
GS
PR
L
ERY
N
GI
P
SME
I
LG
EA
AAGK
S
T
G
D
A
MKFMADLVAE
L
-
-
P
A
G
VGYS
W
T
G
--
LS
YQ
EA
L
SSNQAPA
L
Y
A
-
I
S
L
V
V
VFL
A
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LS
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
VEMM
Q
KE
----------
G
KTPV
EA
IIE
A
ARM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
VI
S
H
GAGSG
AQNA
VG
T
GVMGGM
FA
A
T
V
LAI
Y
fig|362663.9.peg.3658
Escherichia coli 536 (16-1018/1037)
AI
I
M
M
L
A
G
GLA
I
MN
LPV
A
QYP
Q
I
AP
P
T
I
T
I
S
A
T
YPGA
D
AQ
T
V
E
D
S
VT
Q
VIE
QN
M
NG
L
D
GLM
Y
MSS
T
S
DAA
G
NAS
ITL
T
FE
T
GT
S
PD
I
A
QV
QVQ
NK
LQ
L
A
MPS
LP
EAVQQQ
G
I
SVD-KSSSN
---
I
L
MVA
A
FI
S
DNGSLNQY
DI
A
D
Y
V
ASN
I
KDP
LS
RTA
GVG
S
V
QLF
G
SEY-AM
RI
W
LDP
QK
LN
KYN
L
VPSD
V
IS
Q
I
KVQ
N
NQISG
GQLGG
M
P
QAADQQLNAS
I
I
V
QTR
LQT
P
EEF
GK
I
L
L
KVQQ
DG
SQ
V
L
L
R
DVA
R
VE
L
G
A
E
DYSTV
A
RY
NGK
-
P
A
A
G
IA
I
K
L
AT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAY
FP
A
S
L
K
TVYP
YDTT
PF
I
KI
SI
Q
E
VFKT
L
V
EAI
I
LV
F
LV
M
YLFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
A
I
L
S
A
V
G
F
T
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
D
KLP
P
KE
A
TH
K
SMG
QIQ
R
AL
VGIAVV
L
S
AVF
M
PM
A
F
MS
G
AT
G
E
IYR
Q
FSIT
LIS
S
M
LL
SV
F
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNTLFARF
N
TL
F
EKSTQH
----
Y
TDSTR
S
L
L
RCTGRY
M
V
VY
L
L
ICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
L
P
S
G
A
T
MVNTTKVLQ
Q
VT
DYY
LTKEKNN
V
Q
SVF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVT
AII
Q
RA
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AEL
G
TA
S
GFDME
L
LDNGNLGH
E
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
IG
V
RP
N
G
LE
DTPMFK
VNV
N
AA
KA
E
A
M
GV
A
L
S
DI
NQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
ML
P
DN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
GS
PR
L
ERY
N
GI
P
SME
I
LG
EA
AAGK
S
T
G
D
A
MKFMADLVAE
L
-
-
P
A
G
VGYS
W
T
G
--
LS
YQ
EA
L
SSNQAPA
L
Y
A
-
I
S
L
V
V
VFL
A
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LS
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
VEMM
Q
KE
----------
G
KTPV
EA
IIE
A
ARM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
VI
S
H
GAGSG
AQNA
VG
T
GVMGGM
FA
A
T
V
LAI
Y
fig|340197.3.peg.651
Escherichia coli F11 (16-1018/1037)
AI
I
M
M
L
A
G
GLA
I
MN
LPV
A
QYP
Q
I
AP
P
T
I
T
I
S
A
T
YPGA
D
AQ
T
V
E
D
S
VT
Q
VIE
QN
M
NG
L
D
GLM
Y
MSS
T
S
DAA
G
NAS
ITL
T
FE
T
GT
S
PD
I
A
QV
QVQ
NK
LQ
L
A
MPS
LP
EAVQQQ
G
I
SVD-KSSSN
---
I
L
MVA
A
FI
S
DNGSLNQY
DI
A
D
Y
V
ASN
I
KDP
LS
RTA
GVG
S
V
QLF
G
SEY-AM
RI
W
LDP
QK
LN
KYN
L
VPSD
V
IS
Q
I
KVQ
N
NQISG
GQLGG
M
P
QAADQQLNAS
I
I
V
QTR
LQT
P
EEF
GK
I
L
L
KVQQ
DG
SQ
V
L
L
R
DVA
R
VE
L
G
A
E
DYSTV
A
RY
NGK
-
P
A
A
G
IA
I
K
L
AT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAY
FP
A
S
L
K
TVYP
YDTT
PF
I
KI
SI
Q
E
VFKT
L
V
EAI
I
LV
F
LV
M
YLFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
A
I
L
S
A
V
G
F
T
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
D
KLP
P
KE
A
TH
K
SMG
QIQ
R
AL
VGIAVV
L
S
AVF
M
PM
A
F
MS
G
AT
G
E
IYR
Q
FSIT
LIS
S
M
LL
SV
F
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNTLFARF
N
TL
F
EKSTQH
----
Y
TDSTR
S
L
L
RCTGRY
M
V
VY
L
L
ICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
L
P
S
G
A
T
MVNTTKVLQ
Q
VT
DYY
LTKEKNN
V
Q
SVF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVT
AII
Q
RA
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AEL
G
TA
S
GFDME
L
LDNGNLGH
E
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
IG
V
RP
N
G
LE
DTPMFK
VNV
N
AA
KA
E
A
M
GV
A
L
S
DI
NQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
ML
P
DN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
GS
PR
L
ERY
N
GI
P
SME
I
LG
EA
AAGK
S
T
G
D
A
MKFMADLVAE
L
-
-
P
A
G
VGYS
W
T
G
--
LS
YQ
EA
L
SSNQAPA
L
Y
A
-
I
S
L
V
V
VFL
A
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LS
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
VEMM
Q
KE
----------
G
KTPV
EA
IIE
A
ARM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
VI
S
H
GAGSG
AQNA
VG
T
GVMGGM
FA
A
T
V
LAI
Y
fig|340197.5.peg.675
Escherichia coli F11 (16-1018/1037)
AI
I
M
M
L
A
G
GLA
I
MN
LPV
A
QYP
Q
I
AP
P
T
I
T
I
S
A
T
YPGA
D
AQ
T
V
E
D
S
VT
Q
VIE
QN
M
NG
L
D
GLM
Y
MSS
T
S
DAA
G
NAS
ITL
T
FE
T
GT
S
PD
I
A
QV
QVQ
NK
LQ
L
A
MPS
LP
EAVQQQ
G
I
SVD-KSSSN
---
I
L
MVA
A
FI
S
DNGSLNQY
DI
A
D
Y
V
ASN
I
KDP
LS
RTA
GVG
S
V
QLF
G
SEY-AM
RI
W
LDP
QK
LN
KYN
L
VPSD
V
IS
Q
I
KVQ
N
NQISG
GQLGG
M
P
QAADQQLNAS
I
I
V
QTR
LQT
P
EEF
GK
I
L
L
KVQQ
DG
SQ
V
L
L
R
DVA
R
VE
L
G
A
E
DYSTV
A
RY
NGK
-
P
A
A
G
IA
I
K
L
AT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAY
FP
A
S
L
K
TVYP
YDTT
PF
I
KI
SI
Q
E
VFKT
L
V
EAI
I
LV
F
LV
M
YLFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
A
I
L
S
A
V
G
F
T
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
D
KLP
P
KE
A
TH
K
SMG
QIQ
R
AL
VGIAVV
L
S
AVF
M
PM
A
F
MS
G
AT
G
E
IYR
Q
FSIT
LIS
S
M
LL
SV
F
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNTLFARF
N
TL
F
EKSTQH
----
Y
TDSTR
S
L
L
RCTGRY
M
V
VY
L
L
ICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
L
P
S
G
A
T
MVNTTKVLQ
Q
VT
DYY
LTKEKNN
V
Q
SVF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVT
AII
Q
RA
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AEL
G
TA
S
GFDME
L
LDNGNLGH
E
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
IG
V
RP
N
G
LE
DTPMFK
VNV
N
AA
KA
E
A
M
GV
A
L
S
DI
NQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
ML
P
DN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
GS
PR
L
ERY
N
GI
P
SME
I
LG
EA
AAGK
S
T
G
D
A
MKFMADLVAE
L
-
-
P
A
G
VGYS
W
T
G
--
LS
YQ
EA
L
SSNQAPA
L
Y
A
-
I
S
L
V
V
VFL
A
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LS
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
VEMM
Q
KE
----------
G
KTPV
EA
IIE
A
ARM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
VI
S
H
GAGSG
AQNA
VG
T
GVMGGM
FA
A
T
V
LAI
Y
fig|749550.3.peg.2940
Escherichia coli MS 200-1 (16-1018/1037)
AI
I
M
M
L
A
G
GLA
I
MN
LPV
A
QYP
Q
I
AP
P
T
I
T
I
S
A
T
YPGA
D
AQ
T
V
E
D
S
VT
Q
VIE
QN
M
NG
L
D
GLM
Y
MSS
T
S
DAA
G
NAS
ITL
T
FE
T
GT
S
PD
I
A
QV
QVQ
NK
LQ
L
A
MPS
LP
EAVQQQ
G
I
SVD-KSSSN
---
I
L
MVA
A
FI
S
DNGSLNQY
DI
A
D
Y
V
ASN
I
KDP
LS
RTA
GVG
S
V
QLF
G
SEY-AM
RI
W
LDP
QK
LN
KYN
L
VPSD
V
IS
Q
I
KVQ
N
NQISG
GQLGG
M
P
QAADQQLNAS
I
I
V
QTR
LQT
P
EEF
GK
I
L
L
KVQQ
DG
SQ
V
L
L
R
DVA
R
VE
L
G
A
E
DYSTV
A
RY
NGK
-
P
A
A
G
IA
I
K
L
AT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAY
FP
A
S
L
K
TVYP
YDTT
PF
I
KI
SI
Q
E
VFKT
L
V
EAI
I
LV
F
LV
M
YLFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
A
I
L
S
A
V
G
F
T
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
D
KLP
P
KE
A
TH
K
SMG
QIQ
R
AL
VGIAVV
L
S
AVF
M
PM
A
F
MS
G
AT
G
E
IYR
Q
FSIT
LIS
S
M
LL
SV
F
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNTLFARF
N
TL
F
EKSTQH
----
Y
TDSTR
S
L
L
RCTGRY
M
V
VY
L
L
ICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
L
P
S
G
A
T
MVNTTKVLQ
Q
VT
DYY
LTKEKNN
V
Q
SVF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVT
AII
Q
RA
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AEL
G
TA
S
GFDME
L
LDNGNLGH
E
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
IG
V
RP
N
G
LE
DTPMFK
VNV
N
AA
KA
E
A
M
GV
A
L
S
DI
NQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
ML
P
DN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
GS
PR
L
ERY
N
GI
P
SME
I
LG
EA
AAGK
S
T
G
D
A
MKFMADLVAE
L
-
-
P
A
G
VGYS
W
T
G
--
LS
YQ
EA
L
SSNQAPA
L
Y
A
-
I
S
L
V
V
VFL
A
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LS
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
VEMM
Q
KE
----------
G
KTPV
EA
IIE
A
ARM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
VI
S
H
GAGSG
AQNA
VG
T
GVMGGM
FA
A
T
V
LAI
Y
fig|685038.3.peg.2129
Escherichia coli O83:H1 str. NRG 857C (17-1021/1040)
I
M
RPVA
TTL
L
----
M
V
A
I
L
L
A
G
IIG
Y
RA
LPV
S
AL
P
E
V
DY
P
T
I
Q
V
V
T
L
YPGA
S
PD
V
M
T
S
A
VT
A
PL
E
RQ
F
GQ
M
S
GL
K
Q
MSS
Q
S
SG-
G
ASV
ITL
Q
F
Q
L
TL
P
L
D
V
A
EQ
E
VQ
AA
IN
A
A
TNL
LP
SDLPNP
P
V
YSKVNPADP
---
P
I
MTL
A
VT
S
T--AMPMT
Q
V
E
D
M
V
ETR
V
AQK
I
S
QIS
GVG
L
V
TLS
G
GQRPAV
R
V
K
L
NA
QA
IA
ALG
L
TSES
V
RT
AI
TGA
N
VNSAK
G
S
L
--
-
-
--DGPSRAVT
L
S
A
NDQ
M
Q
S
A
EE
Y
RQ
L
I
I
AYQ-
N
G
AP
I
R
L
G
DVA
T
VE
Q
G
A
E
NSWLG
A
WA
N
K
E
-
Q
A
I
V
MN
V
Q
R
QP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TES
L
P
K
S
VK
VTVL
S
D
R
T
TN
I
RA
S
V
D
D
TQFE
L
M
M
AI
A
LV
V
M
I
I
YLFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
A
V
M
V
F
L
D
F
S
I
N
N
LT
L
M
A
L
T
I
A
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
K
GEK
P
LA
A
AL
K
GAG
E
I
G
F
TI
ISLTFS
L
I
AV
L
IP
L
L
F
MG
D
IV
G
R
LF
R
E
F
A
IT
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRAS
E
KM
F
DRIIAA
----
Y
GRGLA
KVL
NHPWLT
L
S
V
A
L
S
TLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VA
D
--
VILQDPA
V
Q
S
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQ
V
SR
T
QYQFT
L
QAT---SL
D
A
L
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
QD
KGLVAY
VNVD
RD
S
A
S
R
L
G
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
L
E
HNTEN
T
PG
L
AA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SF
N
V
PDNY
S
L
G
D
A
VQAIMDTEKT
L
N
L
P
V
D
ITTQ
F
Q
G
ST
LA
F
Q
SA
L
GS--TVW
L
I
V
-
A
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
D
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAE
R
EQ
----------
G
MSPR
EA
IYQ
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
IV
S
Q
V
L
T
L
F
TT
P
VI
Y
L
L
fig|155864.1.peg.4402
Escherichia coli O157:H7 EDL933 (16-1018/1037)
AI
I
M
M
L
A
G
GLA
I
MN
LPV
A
QYP
Q
I
AP
P
T
I
T
V
S
A
T
YPGA
D
AQ
T
V
E
D
S
VT
Q
VIE
QN
M
NG
L
D
GLM
Y
MSS
T
S
DAA
G
NAS
ITL
T
FE
T
GT
S
PD
I
A
QV
QVQ
NK
LQ
L
A
MPS
LP
EAVQQQ
G
I
SVD-KSSSN
---
I
L
MVA
A
FI
S
DNGSLNQY
DI
A
D
Y
V
ASN
I
KDP
LS
RTA
GVG
S
V
QLF
G
SEY-AM
RI
W
LDP
QK
LN
KYN
L
VPSD
V
IS
Q
I
KVQ
N
NQISG
GQLGG
M
P
QAADQQLNAS
I
I
V
QTR
LQT
P
EEF
GK
I
L
L
KVQQ
DG
SQ
V
L
L
R
DVA
R
VE
L
G
A
E
DYSTV
A
RY
NGK
-
P
A
A
G
IA
I
K
L
AT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAY
FP
A
S
L
K
TVYP
YDTT
PF
I
EI
SI
Q
E
VFKT
L
V
EAI
I
X
V
F
LV
M
YLFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
A
I
L
S
A
V
G
F
T
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
D
KLP
P
KE
A
TH
K
SMG
QIQ
R
AL
VGIAVV
L
S
AVF
M
PM
A
F
MS
G
AT
G
E
IYR
Q
FSIT
LIS
S
M
LL
SV
F
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARF
N
TL
F
EKSTQH
----
Y
TDSTR
S
L
L
RCTGRY
M
V
I
Y
L
L
ICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
L
P
S
G
A
T
MVNTTKVLQ
Q
VT
DYY
LTKEKDN
V
Q
SVF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVT
AII
Q
RA
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AEL
G
TA
S
GFDME
L
LDNGNLGH
E
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
TG
V
RP
N
G
LE
DTPMFK
VNV
N
AA
KA
E
A
M
GV
A
L
S
DI
NQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
ML
P
DN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
GS
PR
L
ERY
N
GI
P
SME
I
LG
EA
AAGK
S
T
G
D
A
MKFMADLVAK
L
-
-
P
A
G
VGYS
W
T
G
--
LS
YQ
EA
L
SSNQAPA
L
Y
A
-
I
S
L
V
V
VFL
A
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LS
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
VEMM
Q
KE
----------
G
KTPI
EA
IIE
A
ARM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
VI
S
H
GAGSG
AQNA
VG
T
GVMGGM
FA
A
T
V
LAI
Y
fig|155864.8.peg.4349
Escherichia coli O157:H7 EDL933 (16-1018/1037)
AI
I
M
M
L
A
G
GLA
I
MN
LPV
A
QYP
Q
I
AP
P
T
I
T
V
S
A
T
YPGA
D
AQ
T
V
E
D
S
VT
Q
VIE
QN
M
NG
L
D
GLM
Y
MSS
T
S
DAA
G
NAS
ITL
T
FE
T
GT
S
PD
I
A
QV
QVQ
NK
LQ
L
A
MPS
LP
EAVQQQ
G
I
SVD-KSSSN
---
I
L
MVA
A
FI
S
DNGSLNQY
DI
A
D
Y
V
ASN
I
KDP
LS
RTA
GVG
S
V
QLF
G
SEY-AM
RI
W
LDP
QK
LN
KYN
L
VPSD
V
IS
Q
I
KVQ
N
NQISG
GQLGG
M
P
QAADQQLNAS
I
I
V
QTR
LQT
P
EEF
GK
I
L
L
KVQQ
DG
SQ
V
L
L
R
DVA
R
VE
L
G
A
E
DYSTV
A
RY
NGK
-
P
A
A
G
IA
I
K
L
AT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAY
FP
A
S
L
K
TVYP
YDTT
PF
I
EI
SI
Q
E
VFKT
L
V
EAI
I
X
V
F
LV
M
YLFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
A
I
L
S
A
V
G
F
T
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
D
KLP
P
KE
A
TH
K
SMG
QIQ
R
AL
VGIAVV
L
S
AVF
M
PM
A
F
MS
G
AT
G
E
IYR
Q
FSIT
LIS
S
M
LL
SV
F
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARF
N
TL
F
EKSTQH
----
Y
TDSTR
S
L
L
RCTGRY
M
V
I
Y
L
L
ICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
L
P
S
G
A
T
MVNTTKVLQ
Q
VT
DYY
LTKEKDN
V
Q
SVF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVT
AII
Q
RA
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AEL
G
TA
S
GFDME
L
LDNGNLGH
E
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
TG
V
RP
N
G
LE
DTPMFK
VNV
N
AA
KA
E
A
M
GV
A
L
S
DI
NQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
ML
P
DN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
GS
PR
L
ERY
N
GI
P
SME
I
LG
EA
AAGK
S
T
G
D
A
MKFMADLVAK
L
-
-
P
A
G
VGYS
W
T
G
--
LS
YQ
EA
L
SSNQAPA
L
Y
A
-
I
S
L
V
V
VFL
A
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LS
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
VEMM
Q
KE
----------
G
KTPI
EA
IIE
A
ARM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
VI
S
H
GAGSG
AQNA
VG
T
GVMGGM
FA
A
T
V
LAI
Y
fig|656419.3.peg.4527
Escherichia coli M718 (16-1018/1037)
AI
I
M
M
L
A
G
GLA
I
MN
LPV
A
QYP
Q
I
AP
P
T
I
T
V
S
A
T
YPGA
D
AQ
T
V
E
D
S
VT
Q
VIE
QN
M
NG
L
D
GLM
Y
MSS
T
S
DAA
G
NAS
ITL
T
FE
T
GT
S
PD
I
A
QV
QVQ
NK
LQ
L
A
MPS
LP
EAVQQQ
G
I
SVD-KSSSN
---
I
L
MVA
A
FI
S
DNGSLNQY
DI
A
D
Y
V
ASN
I
KDP
LS
RTA
GVG
S
V
QLF
G
SEY-AM
RI
W
LDP
QK
LN
KYN
L
VPSD
V
IS
Q
I
KVQ
N
NQISG
GQLGG
M
P
QAADQQLNAS
I
I
V
QTR
LQT
P
EEF
GK
I
L
L
KVQQ
DG
SQ
V
L
L
R
DVA
R
VE
L
G
A
E
DYSTV
A
RY
NGK
-
P
A
A
G
IA
I
K
L
AT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAY
FP
A
S
L
K
TVYP
YDTT
PF
I
EI
SI
Q
E
VFKT
L
V
EAI
I
LV
F
LV
M
YLFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
A
I
L
S
A
V
G
F
T
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
D
KLP
P
KE
A
TH
K
SMG
QIQ
R
AL
VGIAVV
L
S
AVF
M
PM
A
F
MS
G
AT
G
E
IYR
Q
FSIT
LIS
S
M
LL
SV
F
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARF
N
TL
F
EKSTQH
----
Y
TDSTR
S
L
L
RCTGRY
M
V
I
Y
L
L
ICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
L
P
S
G
A
T
MVNTTKVLQ
Q
VT
DYY
LTKEKDN
V
Q
SVF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVT
AII
Q
RA
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AEL
G
TA
S
GFDME
L
LDNGNLGH
E
K
L
TQARN
E
L
LSL
A
AQA
P
NQ
V
TG
V
RP
N
G
LE
DTPMFK
VNV
N
AA
KA
E
A
M
GV
A
L
S
DI
NQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
ML
P
DN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
GS
PR
L
ERY
N
GI
P
SME
I
LG
EA
AAGK
S
T
G
D
A
MKFMADLVAK
L
-
-
P
A
G
VGYS
W
T
G
--
LS
YQ
EA
L
SSNQAPA
L
Y
A
-
I
S
L
V
V
VFL
A
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LS
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
VEMM
Q
KE
----------
G
KTPI
EA
IIE
A
ARM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
VI
S
H
GAGSG
AQNA
VG
T
GVMGGM
FA
A
T
V
LAI
Y
fig|749547.3.peg.1992
Escherichia coli MS 187-1 (16-1018/1037)
AI
I
M
M
L
A
G
GLA
I
MN
LPV
A
QYP
Q
I
AP
P
T
I
T
V
S
A
T
YPGA
D
AQ
T
V
E
D
S
VT
Q
VIE
QN
M
NG
L
D
GLM
Y
MSS
T
S
DAA
G
NAS
ITL
T
FE
T
GT
S
PD
I
A
QV
QVQ
NK
LQ
L
A
MPS
LP
EAVQQQ
G
I
SVD-KSSSN
---
I
L
MVA
A
FI
S
DNGSLNQY
DI
A
D
Y
V
ASN
I
KDP
LS
RTA
GVG
S
V
QLF
G
SEY-AM
RI
W
LDP
QK
LN
KYN
L
VPSD
V
IS
Q
I
KVQ
N
NQISG
GQLGG
M
P
QAADQQLNAS
I
I
V
QTR
LQT
P
EEF
GK
I
L
L
KVQQ
DG
SQ
V
L
L
R
DVA
R
VE
L
G
A
E
DYSTV
A
RY
NGK
-
P
A
A
G
IA
I
K
L
AA
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAY
FP
A
S
L
K
TVYP
YDTT
PF
I
EI
SI
Q
E
VFKT
L
V
EAI
I
LV
F
LV
M
YLFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
A
I
L
S
A
V
G
F
T
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
D
KLP
P
KE
A
TH
K
SMG
QIQ
R
AL
VGIAVV
L
S
AVF
M
PM
A
F
MS
G
AT
G
E
IYR
Q
FSIT
LIS
S
M
LL
SV
F
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARF
N
TL
F
EKSTQH
----
Y
TDSTR
S
L
L
RCTGRY
M
V
VY
L
L
ICAGVAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
L
P
S
G
A
T
MVNTTKVLQ
Q
VT
DYY
LTKEKDN
V
Q
SVF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVT
AII
Q
RA
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AEL
G
TA
S
GFDME
L
LDNGNLGH
E
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
TG
V
RP
N
G
LE
DTPMFK
VNV
N
AA
KA
E
A
M
GV
A
L
S
DI
NQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
ML
P
DN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
GS
PR
L
ERY
N
GI
P
SME
I
LG
EA
AAGK
S
T
G
D
A
MKFMADLVAK
L
-
-
P
A
G
VGYS
W
T
G
--
LS
YQ
EA
L
SSNQAPA
L
Y
A
-
I
S
L
V
V
VFL
A
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LS
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
VEMM
Q
KE
----------
G
KTPI
EA
IIE
A
ARM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
VI
S
H
GAGSG
AQNA
VG
T
GVMGGM
FA
A
T
V
LAI
Y
fig|753642.3.peg.4423
Escherichia coli NC101 (16-1018/1037)
AI
I
M
M
L
A
G
GLA
I
MN
LPV
A
QYP
Q
I
AP
P
T
I
T
I
S
A
T
YPGA
D
AQ
T
V
E
D
S
VT
Q
VIE
QN
M
NG
L
D
GLM
Y
MSS
T
S
DAA
G
NAS
ITL
T
FE
T
GT
S
PD
I
A
QV
QVQ
NK
LQ
L
A
MPS
LP
EAVQQQ
G
I
SVD-KSSSN
---
I
L
MVA
A
FI
S
DNGSLNQY
DI
A
D
Y
V
ASN
I
KDP
LS
RTA
GVG
S
V
QLF
G
SEY-AM
RI
W
LDP
QK
LN
KYN
L
VPSD
V
IS
Q
I
KVQ
N
NQISG
GQLGG
M
P
QAADQQLNAS
I
I
V
QTR
LQT
P
EEF
GK
I
L
L
KVQQ
DG
SQ
V
L
L
R
DVA
R
VE
L
G
A
E
DYSTV
A
RY
NGK
-
P
A
A
G
IA
I
K
L
AT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAY
FP
A
S
L
K
TVYP
YDTT
PF
I
KI
SI
Q
E
VFKT
L
V
EAI
I
LV
F
LV
M
YLFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
A
I
L
S
A
V
G
F
T
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
D
KLP
P
KE
A
TH
K
SMG
QIQ
R
AL
VGIAVV
L
S
AVF
M
PM
A
F
MS
G
AT
G
E
IYR
Q
FSIT
LIS
S
M
LL
SV
F
VA
M
S
LTP
A
LCA
TI
L
KAAPEGDHK-PNALFARF
N
TL
F
EKSTQH
----
Y
TDSTR
S
L
L
RCTGRY
M
V
VY
L
L
ICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
L
P
S
G
A
T
MVNTTKVLQ
Q
VT
DYY
LTKEKNN
V
Q
SVF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVT
AII
Q
RA
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AEL
G
TA
S
GFDME
L
LDNGNLGH
E
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
IG
V
RP
N
G
LE
DTPMFK
VNV
N
AA
KA
E
A
M
GV
A
L
S
DI
NQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
ML
P
DN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
GS
PR
L
ERY
N
GI
P
SME
I
LG
EA
AAGK
S
T
G
D
A
MKFMADLVAK
L
-
-
P
A
G
VGYS
W
T
G
--
LS
YQ
EA
L
SSNQAPA
L
Y
A
-
I
S
L
V
V
VFL
A
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LS
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
VEMM
Q
KE
----------
G
KTPV
EA
IIE
A
ARM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
VI
S
H
GAGSG
AQNA
VG
T
GVMGGM
FA
A
T
V
LAI
Y
fig|670897.3.peg.3837
Escherichia coli 2362-75 (16-1018/1037)
AI
I
M
M
L
A
G
GLA
I
MN
LPV
A
QYP
Q
I
AP
P
T
I
T
I
S
A
T
YPGA
D
AQ
T
V
E
D
S
VT
Q
VIE
QN
M
NG
L
D
GLM
Y
MSS
T
S
DAA
G
NAS
ITL
T
FE
T
GT
S
PD
I
A
QV
QVQ
NK
LQ
L
A
MPS
LP
EAVQQQ
G
I
SVD-KSSSN
---
I
L
MVA
A
FI
S
DNGSLNQY
DI
A
D
Y
V
ASN
I
KDP
LS
RTA
GVG
S
V
QLF
G
SEY-AM
RI
W
LDP
QK
LN
KYN
L
VPSD
V
IS
Q
I
KVQ
N
NQISG
GQLGG
M
P
QAADQQLNAS
I
I
V
QTR
LQT
P
EEF
GK
I
L
L
KVQQ
DG
SQ
V
L
L
R
DVA
R
VE
L
G
A
E
DYSTV
A
RY
NGK
-
P
A
A
G
IA
I
K
L
AT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAY
FP
A
S
L
K
TVYP
YDTT
PF
I
KI
SI
Q
E
VFKT
L
V
EAI
I
LV
F
LV
M
YLFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
A
I
L
S
A
V
G
F
T
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
D
KLP
P
KE
A
TH
K
SMG
QIQ
R
AL
VGIAVV
L
S
AVF
M
PM
A
F
MS
G
AT
G
E
IYR
Q
FSIT
LIS
S
M
LL
SV
F
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARF
N
TL
F
EKSTQH
----
Y
TDSTR
S
L
L
RCTGRY
M
V
VY
L
L
ICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
L
P
S
G
A
T
MVNTTKVLQ
Q
VT
DYY
LTKEKNN
V
Q
SVF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVT
AII
Q
RA
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AEL
G
TA
S
GFDME
L
LDNGNLGH
E
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
IG
V
RP
N
G
LE
DTPMFK
VNV
N
AA
KA
E
A
M
GV
A
L
S
DI
NQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
ML
P
DN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
GS
PR
L
ERY
N
GI
P
SME
I
LG
EA
AAGK
S
T
G
D
A
MKFMADLVAK
L
-
-
P
A
G
VGYS
W
T
G
--
LS
YQ
EA
L
SSNQAPA
L
Y
A
-
I
S
L
V
V
VFL
A
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LS
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
VEMM
Q
KE
----------
G
KTPV
EA
IIE
A
ARM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
VI
S
H
GAGSG
AQNA
VG
T
GVMGGM
FA
A
T
V
LAI
Y
fig|405955.13.peg.3957
Escherichia coli APEC O1 (16-1018/1037)
AI
I
M
M
L
A
G
GLA
I
MN
LPV
A
QYP
Q
I
AP
P
T
I
T
I
S
A
T
YPGA
D
AQ
T
V
E
D
S
VT
Q
VIE
QN
M
NG
L
D
GLM
Y
MSS
T
S
DAA
G
NAS
ITL
T
FE
T
GT
S
PD
I
A
QV
QVQ
NK
LQ
L
A
MPS
LP
EAVQQQ
G
I
SVD-KSSSN
---
I
L
MVA
A
FI
S
DNGSLNQY
DI
A
D
Y
V
ASN
I
KDP
LS
RTA
GVG
S
V
QLF
G
SEY-AM
RI
W
LDP
QK
LN
KYN
L
VPSD
V
IS
Q
I
KVQ
N
NQISG
GQLGG
M
P
QAADQQLNAS
I
I
V
QTR
LQT
P
EEF
GK
I
L
L
KVQQ
DG
SQ
V
L
L
R
DVA
R
VE
L
G
A
E
DYSTV
A
RY
NGK
-
P
A
A
G
IA
I
K
L
AT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAY
FP
A
S
L
K
TVYP
YDTT
PF
I
KI
SI
Q
E
VFKT
L
V
EAI
I
LV
F
LV
M
YLFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
A
I
L
S
A
V
G
F
T
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
D
KLP
P
KE
A
TH
K
SMG
QIQ
R
AL
VGIAVV
L
S
AVF
M
PM
A
F
MS
G
AT
G
E
IYR
Q
FSIT
LIS
S
M
LL
SV
F
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARF
N
TL
F
EKSTQH
----
Y
TDSTR
S
L
L
RCTGRY
M
V
VY
L
L
ICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
L
P
S
G
A
T
MVNTTKVLQ
Q
VT
DYY
LTKEKNN
V
Q
SVF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVT
AII
Q
RA
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AEL
G
TA
S
GFDME
L
LDNGNLGH
E
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
IG
V
RP
N
G
LE
DTPMFK
VNV
N
AA
KA
E
A
M
GV
A
L
S
DI
NQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
ML
P
DN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
GS
PR
L
ERY
N
GI
P
SME
I
LG
EA
AAGK
S
T
G
D
A
MKFMADLVAK
L
-
-
P
A
G
VGYS
W
T
G
--
LS
YQ
EA
L
SSNQAPA
L
Y
A
-
I
S
L
V
V
VFL
A
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LS
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
VEMM
Q
KE
----------
G
KTPV
EA
IIE
A
ARM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
VI
S
H
GAGSG
AQNA
VG
T
GVMGGM
FA
A
T
V
LAI
Y
fig|405955.9.peg.3311
Escherichia coli APEC O1 (16-1018/1037)
AI
I
M
M
L
A
G
GLA
I
MN
LPV
A
QYP
Q
I
AP
P
T
I
T
I
S
A
T
YPGA
D
AQ
T
V
E
D
S
VT
Q
VIE
QN
M
NG
L
D
GLM
Y
MSS
T
S
DAA
G
NAS
ITL
T
FE
T
GT
S
PD
I
A
QV
QVQ
NK
LQ
L
A
MPS
LP
EAVQQQ
G
I
SVD-KSSSN
---
I
L
MVA
A
FI
S
DNGSLNQY
DI
A
D
Y
V
ASN
I
KDP
LS
RTA
GVG
S
V
QLF
G
SEY-AM
RI
W
LDP
QK
LN
KYN
L
VPSD
V
IS
Q
I
KVQ
N
NQISG
GQLGG
M
P
QAADQQLNAS
I
I
V
QTR
LQT
P
EEF
GK
I
L
L
KVQQ
DG
SQ
V
L
L
R
DVA
R
VE
L
G
A
E
DYSTV
A
RY
NGK
-
P
A
A
G
IA
I
K
L
AT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAY
FP
A
S
L
K
TVYP
YDTT
PF
I
KI
SI
Q
E
VFKT
L
V
EAI
I
LV
F
LV
M
YLFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
A
I
L
S
A
V
G
F
T
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
D
KLP
P
KE
A
TH
K
SMG
QIQ
R
AL
VGIAVV
L
S
AVF
M
PM
A
F
MS
G
AT
G
E
IYR
Q
FSIT
LIS
S
M
LL
SV
F
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARF
N
TL
F
EKSTQH
----
Y
TDSTR
S
L
L
RCTGRY
M
V
VY
L
L
ICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
L
P
S
G
A
T
MVNTTKVLQ
Q
VT
DYY
LTKEKNN
V
Q
SVF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVT
AII
Q
RA
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AEL
G
TA
S
GFDME
L
LDNGNLGH
E
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
IG
V
RP
N
G
LE
DTPMFK
VNV
N
AA
KA
E
A
M
GV
A
L
S
DI
NQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
ML
P
DN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
GS
PR
L
ERY
N
GI
P
SME
I
LG
EA
AAGK
S
T
G
D
A
MKFMADLVAK
L
-
-
P
A
G
VGYS
W
T
G
--
LS
YQ
EA
L
SSNQAPA
L
Y
A
-
I
S
L
V
V
VFL
A
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LS
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
VEMM
Q
KE
----------
G
KTPV
EA
IIE
A
ARM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
VI
S
H
GAGSG
AQNA
VG
T
GVMGGM
FA
A
T
V
LAI
Y
fig|216593.1.peg.4245
Escherichia coli E2348/69 (16-1018/1037)
AI
I
M
M
L
A
G
GLA
I
MN
LPV
A
QYP
Q
I
AP
P
T
I
T
I
S
A
T
YPGA
D
AQ
T
V
E
D
S
VT
Q
VIE
QN
M
NG
L
D
GLM
Y
MSS
T
S
DAA
G
NAS
ITL
T
FE
T
GT
S
PD
I
A
QV
QVQ
NK
LQ
L
A
MPS
LP
EAVQQQ
G
I
SVD-KSSSN
---
I
L
MVA
A
FI
S
DNGSLNQY
DI
A
D
Y
V
ASN
I
KDP
LS
RTA
GVG
S
V
QLF
G
SEY-AM
RI
W
LDP
QK
LN
KYN
L
VPSD
V
IS
Q
I
KVQ
N
NQISG
GQLGG
M
P
QAADQQLNAS
I
I
V
QTR
LQT
P
EEF
GK
I
L
L
KVQQ
DG
SQ
V
L
L
R
DVA
R
VE
L
G
A
E
DYSTV
A
RY
NGK
-
P
A
A
G
IA
I
K
L
AT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAY
FP
A
S
L
K
TVYP
YDTT
PF
I
KI
SI
Q
E
VFKT
L
V
EAI
I
LV
F
LV
M
YLFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
A
I
L
S
A
V
G
F
T
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
D
KLP
P
KE
A
TH
K
SMG
QIQ
R
AL
VGIAVV
L
S
AVF
M
PM
A
F
MS
G
AT
G
E
IYR
Q
FSIT
LIS
S
M
LL
SV
F
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARF
N
TL
F
EKSTQH
----
Y
TDSTR
S
L
L
RCTGRY
M
V
VY
L
L
ICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
L
P
S
G
A
T
MVNTTKVLQ
Q
VT
DYY
LTKEKNN
V
Q
SVF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVT
AII
Q
RA
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AEL
G
TA
S
GFDME
L
LDNGNLGH
E
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
IG
V
RP
N
G
LE
DTPMFK
VNV
N
AA
KA
E
A
M
GV
A
L
S
DI
NQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
ML
P
DN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
GS
PR
L
ERY
N
GI
P
SME
I
LG
EA
AAGK
S
T
G
D
A
MKFMADLVAK
L
-
-
P
A
G
VGYS
W
T
G
--
LS
YQ
EA
L
SSNQAPA
L
Y
A
-
I
S
L
V
V
VFL
A
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LS
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
VEMM
Q
KE
----------
G
KTPV
EA
IIE
A
ARM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
VI
S
H
GAGSG
AQNA
VG
T
GVMGGM
FA
A
T
V
LAI
Y
fig|714962.3.peg.3989
Escherichia coli IHE3034 (16-1018/1037)
AI
I
M
M
L
A
G
GLA
I
MN
LPV
A
QYP
Q
I
AP
P
T
I
T
I
S
A
T
YPGA
D
AQ
T
V
E
D
S
VT
Q
VIE
QN
M
NG
L
D
GLM
Y
MSS
T
S
DAA
G
NAS
ITL
T
FE
T
GT
S
PD
I
A
QV
QVQ
NK
LQ
L
A
MPS
LP
EAVQQQ
G
I
SVD-KSSSN
---
I
L
MVA
A
FI
S
DNGSLNQY
DI
A
D
Y
V
ASN
I
KDP
LS
RTA
GVG
S
V
QLF
G
SEY-AM
RI
W
LDP
QK
LN
KYN
L
VPSD
V
IS
Q
I
KVQ
N
NQISG
GQLGG
M
P
QAADQQLNAS
I
I
V
QTR
LQT
P
EEF
GK
I
L
L
KVQQ
DG
SQ
V
L
L
R
DVA
R
VE
L
G
A
E
DYSTV
A
RY
NGK
-
P
A
A
G
IA
I
K
L
AT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAY
FP
A
S
L
K
TVYP
YDTT
PF
I
KI
SI
Q
E
VFKT
L
V
EAI
I
LV
F
LV
M
YLFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
A
I
L
S
A
V
G
F
T
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
D
KLP
P
KE
A
TH
K
SMG
QIQ
R
AL
VGIAVV
L
S
AVF
M
PM
A
F
MS
G
AT
G
E
IYR
Q
FSIT
LIS
S
M
LL
SV
F
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARF
N
TL
F
EKSTQH
----
Y
TDSTR
S
L
L
RCTGRY
M
V
VY
L
L
ICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
L
P
S
G
A
T
MVNTTKVLQ
Q
VT
DYY
LTKEKNN
V
Q
SVF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVT
AII
Q
RA
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AEL
G
TA
S
GFDME
L
LDNGNLGH
E
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
IG
V
RP
N
G
LE
DTPMFK
VNV
N
AA
KA
E
A
M
GV
A
L
S
DI
NQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
ML
P
DN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
GS
PR
L
ERY
N
GI
P
SME
I
LG
EA
AAGK
S
T
G
D
A
MKFMADLVAK
L
-
-
P
A
G
VGYS
W
T
G
--
LS
YQ
EA
L
SSNQAPA
L
Y
A
-
I
S
L
V
V
VFL
A
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LS
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
VEMM
Q
KE
----------
G
KTPV
EA
IIE
A
ARM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
VI
S
H
GAGSG
AQNA
VG
T
GVMGGM
FA
A
T
V
LAI
Y
fig|656417.3.peg.4383
Escherichia coli M605 (16-1018/1037)
AI
I
M
M
L
A
G
GLA
I
MN
LPV
A
QYP
Q
I
AP
P
T
I
T
I
S
A
T
YPGA
D
AQ
T
V
E
D
S
VT
Q
VIE
QN
M
NG
L
D
GLM
Y
MSS
T
S
DAA
G
NAS
ITL
T
FE
T
GT
S
PD
I
A
QV
QVQ
NK
LQ
L
A
MPS
LP
EAVQQQ
G
I
SVD-KSSSN
---
I
L
MVA
A
FI
S
DNGSLNQY
DI
A
D
Y
V
ASN
I
KDP
LS
RTA
GVG
S
V
QLF
G
SEY-AM
RI
W
LDP
QK
LN
KYN
L
VPSD
V
IS
Q
I
KVQ
N
NQISG
GQLGG
M
P
QAADQQLNAS
I
I
V
QTR
LQT
P
EEF
GK
I
L
L
KVQQ
DG
SQ
V
L
L
R
DVA
R
VE
L
G
A
E
DYSTV
A
RY
NGK
-
P
A
A
G
IA
I
K
L
AT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAY
FP
A
S
L
K
TVYP
YDTT
PF
I
KI
SI
Q
E
VFKT
L
V
EAI
I
LV
F
LV
M
YLFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
A
I
L
S
A
V
G
F
T
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
D
KLP
P
KE
A
TH
K
SMG
QIQ
R
AL
VGIAVV
L
S
AVF
M
PM
A
F
MS
G
AT
G
E
IYR
Q
FSIT
LIS
S
M
LL
SV
F
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARF
N
TL
F
EKSTQH
----
Y
TDSTR
S
L
L
RCTGRY
M
V
VY
L
L
ICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
L
P
S
G
A
T
MVNTTKVLQ
Q
VT
DYY
LTKEKNN
V
Q
SVF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVT
AII
Q
RA
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AEL
G
TA
S
GFDME
L
LDNGNLGH
E
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
IG
V
RP
N
G
LE
DTPMFK
VNV
N
AA
KA
E
A
M
GV
A
L
S
DI
NQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
ML
P
DN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
GS
PR
L
ERY
N
GI
P
SME
I
LG
EA
AAGK
S
T
G
D
A
MKFMADLVAK
L
-
-
P
A
G
VGYS
W
T
G
--
LS
YQ
EA
L
SSNQAPA
L
Y
A
-
I
S
L
V
V
VFL
A
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LS
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
VEMM
Q
KE
----------
G
KTPV
EA
IIE
A
ARM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
VI
S
H
GAGSG
AQNA
VG
T
GVMGGM
FA
A
T
V
LAI
Y
fig|574521.7.peg.3842
Escherichia coli O127:H6 str. E2348/69 (16-1018/1037)
AI
I
M
M
L
A
G
GLA
I
MN
LPV
A
QYP
Q
I
AP
P
T
I
T
I
S
A
T
YPGA
D
AQ
T
V
E
D
S
VT
Q
VIE
QN
M
NG
L
D
GLM
Y
MSS
T
S
DAA
G
NAS
ITL
T
FE
T
GT
S
PD
I
A
QV
QVQ
NK
LQ
L
A
MPS
LP
EAVQQQ
G
I
SVD-KSSSN
---
I
L
MVA
A
FI
S
DNGSLNQY
DI
A
D
Y
V
ASN
I
KDP
LS
RTA
GVG
S
V
QLF
G
SEY-AM
RI
W
LDP
QK
LN
KYN
L
VPSD
V
IS
Q
I
KVQ
N
NQISG
GQLGG
M
P
QAADQQLNAS
I
I
V
QTR
LQT
P
EEF
GK
I
L
L
KVQQ
DG
SQ
V
L
L
R
DVA
R
VE
L
G
A
E
DYSTV
A
RY
NGK
-
P
A
A
G
IA
I
K
L
AT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAY
FP
A
S
L
K
TVYP
YDTT
PF
I
KI
SI
Q
E
VFKT
L
V
EAI
I
LV
F
LV
M
YLFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
A
I
L
S
A
V
G
F
T
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
D
KLP
P
KE
A
TH
K
SMG
QIQ
R
AL
VGIAVV
L
S
AVF
M
PM
A
F
MS
G
AT
G
E
IYR
Q
FSIT
LIS
S
M
LL
SV
F
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARF
N
TL
F
EKSTQH
----
Y
TDSTR
S
L
L
RCTGRY
M
V
VY
L
L
ICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
L
P
S
G
A
T
MVNTTKVLQ
Q
VT
DYY
LTKEKNN
V
Q
SVF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVT
AII
Q
RA
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AEL
G
TA
S
GFDME
L
LDNGNLGH
E
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
IG
V
RP
N
G
LE
DTPMFK
VNV
N
AA
KA
E
A
M
GV
A
L
S
DI
NQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
ML
P
DN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
GS
PR
L
ERY
N
GI
P
SME
I
LG
EA
AAGK
S
T
G
D
A
MKFMADLVAK
L
-
-
P
A
G
VGYS
W
T
G
--
LS
YQ
EA
L
SSNQAPA
L
Y
A
-
I
S
L
V
V
VFL
A
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LS
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
VEMM
Q
KE
----------
G
KTPV
EA
IIE
A
ARM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
VI
S
H
GAGSG
AQNA
VG
T
GVMGGM
FA
A
T
V
LAI
Y
fig|685038.3.peg.3565
Escherichia coli O83:H1 str. NRG 857C (16-1018/1037)
AI
I
M
M
L
A
G
GLA
I
MN
LPV
A
QYP
Q
I
AP
P
T
I
T
I
S
A
T
YPGA
D
AQ
T
V
E
D
S
VT
Q
VIE
QN
M
NG
L
D
GLM
Y
MSS
T
S
DAA
G
NAS
ITL
T
FE
T
GT
S
PD
I
A
QV
QVQ
NK
LQ
L
A
MPS
LP
EAVQQQ
G
I
SVD-KSSSN
---
I
L
MVA
A
FI
S
DNGSLNQY
DI
A
D
Y
V
ASN
I
KDP
LS
RTA
GVG
S
V
QLF
G
SEY-AM
RI
W
LDP
QK
LN
KYN
L
VPSD
V
IS
Q
I
KVQ
N
NQISG
GQLGG
M
P
QAADQQLNAS
I
I
V
QTR
LQT
P
EEF
GK
I
L
L
KVQQ
DG
SQ
V
L
L
R
DVA
R
VE
L
G
A
E
DYSTV
A
RY
NGK
-
P
A
A
G
IA
I
K
L
AT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAY
FP
A
S
L
K
TVYP
YDTT
PF
I
KI
SI
Q
E
VFKT
L
V
EAI
I
LV
F
LV
M
YLFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
A
I
L
S
A
V
G
F
T
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
D
KLP
P
KE
A
TH
K
SMG
QIQ
R
AL
VGIAVV
L
S
AVF
M
PM
A
F
MS
G
AT
G
E
IYR
Q
FSIT
LIS
S
M
LL
SV
F
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARF
N
TL
F
EKSTQH
----
Y
TDSTR
S
L
L
RCTGRY
M
V
VY
L
L
ICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
L
P
S
G
A
T
MVNTTKVLQ
Q
VT
DYY
LTKEKNN
V
Q
SVF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVT
AII
Q
RA
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AEL
G
TA
S
GFDME
L
LDNGNLGH
E
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
IG
V
RP
N
G
LE
DTPMFK
VNV
N
AA
KA
E
A
M
GV
A
L
S
DI
NQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
ML
P
DN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
GS
PR
L
ERY
N
GI
P
SME
I
LG
EA
AAGK
S
T
G
D
A
MKFMADLVAK
L
-
-
P
A
G
VGYS
W
T
G
--
LS
YQ
EA
L
SSNQAPA
L
Y
A
-
I
S
L
V
V
VFL
A
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LS
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
VEMM
Q
KE
----------
G
KTPV
EA
IIE
A
ARM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
VI
S
H
GAGSG
AQNA
VG
T
GVMGGM
FA
A
T
V
LAI
Y
fig|585035.6.peg.3851
Escherichia coli S88 (16-1018/1037)
AI
I
M
M
L
A
G
GLA
I
MN
LPV
A
QYP
Q
I
AP
P
T
I
T
I
S
A
T
YPGA
D
AQ
T
V
E
D
S
VT
Q
VIE
QN
M
NG
L
D
GLM
Y
MSS
T
S
DAA
G
NAS
ITL
T
FE
T
GT
S
PD
I
A
QV
QVQ
NK
LQ
L
A
MPS
LP
EAVQQQ
G
I
SVD-KSSSN
---
I
L
MVA
A
FI
S
DNGSLNQY
DI
A
D
Y
V
ASN
I
KDP
LS
RTA
GVG
S
V
QLF
G
SEY-AM
RI
W
LDP
QK
LN
KYN
L
VPSD
V
IS
Q
I
KVQ
N
NQISG
GQLGG
M
P
QAADQQLNAS
I
I
V
QTR
LQT
P
EEF
GK
I
L
L
KVQQ
DG
SQ
V
L
L
R
DVA
R
VE
L
G
A
E
DYSTV
A
RY
NGK
-
P
A
A
G
IA
I
K
L
AT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAY
FP
A
S
L
K
TVYP
YDTT
PF
I
KI
SI
Q
E
VFKT
L
V
EAI
I
LV
F
LV
M
YLFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
A
I
L
S
A
V
G
F
T
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
D
KLP
P
KE
A
TH
K
SMG
QIQ
R
AL
VGIAVV
L
S
AVF
M
PM
A
F
MS
G
AT
G
E
IYR
Q
FSIT
LIS
S
M
LL
SV
F
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARF
N
TL
F
EKSTQH
----
Y
TDSTR
S
L
L
RCTGRY
M
V
VY
L
L
ICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
L
P
S
G
A
T
MVNTTKVLQ
Q
VT
DYY
LTKEKNN
V
Q
SVF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVT
AII
Q
RA
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AEL
G
TA
S
GFDME
L
LDNGNLGH
E
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
IG
V
RP
N
G
LE
DTPMFK
VNV
N
AA
KA
E
A
M
GV
A
L
S
DI
NQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
ML
P
DN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
GS
PR
L
ERY
N
GI
P
SME
I
LG
EA
AAGK
S
T
G
D
A
MKFMADLVAK
L
-
-
P
A
G
VGYS
W
T
G
--
LS
YQ
EA
L
SSNQAPA
L
Y
A
-
I
S
L
V
V
VFL
A
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LS
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
VEMM
Q
KE
----------
G
KTPV
EA
IIE
A
ARM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
VI
S
H
GAGSG
AQNA
VG
T
GVMGGM
FA
A
T
V
LAI
Y
fig|431946.3.peg.3484
Escherichia coli SE15 (16-1018/1037)
AI
I
M
M
L
A
G
GLA
I
MN
LPV
A
QYP
Q
I
AP
P
T
I
T
I
S
A
T
YPGA
D
AQ
T
V
E
D
S
VT
Q
VIE
QN
M
NG
L
D
GLM
Y
MSS
T
S
DAA
G
NAS
ITL
T
FE
T
GT
S
PD
I
A
QV
QVQ
NK
LQ
L
A
MPS
LP
EAVQQQ
G
I
SVD-KSSSN
---
I
L
MVA
A
FI
S
DNGSLNQY
DI
A
D
Y
V
ASN
I
KDP
LS
RTA
GVG
S
V
QLF
G
SEY-AM
RI
W
LDP
QK
LN
KYN
L
VPSD
V
IS
Q
I
KVQ
N
NQISG
GQLGG
M
P
QAADQQLNAS
I
I
V
QTR
LQT
P
EEF
GK
I
L
L
KVQQ
DG
SQ
V
L
L
R
DVA
R
VE
L
G
A
E
DYSTV
A
RY
NGK
-
P
A
A
G
IA
I
K
L
AT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAY
FP
A
S
L
K
TVYP
YDTT
PF
I
KI
SI
Q
E
VFKT
L
V
EAI
I
LV
F
LV
M
YLFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
A
I
L
S
A
V
G
F
T
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
D
KLP
P
KE
A
TH
K
SMG
QIQ
R
AL
VGIAVV
L
S
AVF
M
PM
A
F
MS
G
AT
G
E
IYR
Q
FSIT
LIS
S
M
LL
SV
F
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARF
N
TL
F
EKSTQH
----
Y
TDSTR
S
L
L
RCTGRY
M
V
VY
L
L
IFAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
L
P
S
G
A
T
MVNTTKVLQ
Q
VT
DYY
LTKEKNN
V
Q
SVF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVT
AII
Q
RA
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AEL
G
TA
S
GFDME
L
LDNGNLGH
E
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
IG
V
RP
N
G
LE
DTPMFK
VNV
N
AA
KA
E
A
M
GV
A
L
S
DI
NQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
ML
P
DN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
GS
PR
L
ERY
N
GI
P
SME
I
LG
EA
AAGK
S
T
G
D
A
MKFMADLVAK
L
-
-
P
A
G
VGYS
W
T
G
--
LS
YQ
EA
L
SSNQAPA
L
Y
A
-
I
S
L
V
V
VFL
A
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LS
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
VEMM
Q
KE
----------
G
KTPV
EA
IIE
A
ARM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
VI
S
H
GAGSG
AQNA
VG
T
GVMGGM
FA
A
T
V
LAI
Y
fig|656440.3.peg.3778
Escherichia coli TA206 (16-1018/1037)
AI
I
M
M
L
A
G
GLA
I
MN
LPV
A
QYP
Q
I
AP
P
T
I
T
I
S
A
T
YPGA
D
AQ
T
V
E
D
S
VT
Q
VIE
QN
M
NG
L
D
GLM
Y
MSS
T
S
DAA
G
NAS
ITL
T
FE
T
GT
S
PD
I
A
QV
QVQ
NK
LQ
L
A
MPS
LP
EAVQQQ
G
I
SVD-KSSSN
---
I
L
MVA
A
FI
S
DNGSLNQY
DI
A
D
Y
V
ASN
I
KDP
LS
RTA
GVG
S
V
QLF
G
SEY-AM
RI
W
LDP
QK
LN
KYN
L
VPSD
V
IS
Q
I
KVQ
N
NQISG
GQLGG
M
P
QAADQQLNAS
I
I
V
QTR
LQT
P
EEF
GK
I
L
L
KVQQ
DG
SQ
V
L
L
R
DVA
R
VE
L
G
A
E
DYSTV
A
RY
NGK
-
P
A
A
G
IA
I
K
L
AT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAY
FP
A
S
L
K
TVYP
YDTT
PF
I
KI
SI
Q
E
VFKT
L
V
EAI
I
LV
F
LV
M
YLFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
A
I
L
S
A
V
G
F
T
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
D
KLP
P
KE
A
TH
K
SMG
QIQ
R
AL
VGIAVV
L
S
AVF
M
PM
A
F
MS
G
AT
G
E
IYR
Q
FSIT
LIS
S
M
LL
SV
F
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARF
N
TL
F
EKSTQH
----
Y
TDSTR
S
L
L
RCTGRY
M
V
VY
L
L
ICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
L
P
S
G
A
T
MVNTTKVLQ
Q
VT
DYY
LTKEKNN
V
Q
SVF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVT
AII
Q
RA
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AEL
G
TA
S
GFDME
L
LDNGNLGH
E
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
IG
V
RP
N
G
LE
DTPMFK
VNV
N
AA
KA
E
A
M
GV
A
L
S
DI
NQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
ML
P
DN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
GS
PR
L
ERY
N
GI
P
SME
I
LG
EA
AAGK
S
T
G
D
A
MKFMADLVAK
L
-
-
P
A
G
VGYS
W
T
G
--
LS
YQ
EA
L
SSNQAPA
L
Y
A
-
I
S
L
V
V
VFL
A
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LS
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
VEMM
Q
KE
----------
G
KTPV
EA
IIE
A
ARM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
VI
S
H
GAGSG
AQNA
VG
T
GVMGGM
FA
A
T
V
LAI
Y
fig|562.376.peg.2729
Escherichia coli WV_060327 (16-1018/1037)
AI
I
M
M
L
A
G
GLA
I
MN
LPV
A
QYP
Q
I
AP
P
T
I
T
I
S
A
T
YPGA
D
AQ
T
V
E
D
S
VT
Q
VIE
QN
M
NG
L
D
GLM
Y
MSS
T
S
DAA
G
NAS
ITL
T
FE
T
GT
S
PD
I
A
QV
QVQ
NK
LQ
L
A
MPS
LP
EAVQQQ
G
I
SVD-KSSSN
---
I
L
MVA
A
FI
S
DNGSLNQY
DI
A
D
Y
V
ASN
I
KDP
LS
RTA
GVG
S
V
QLF
G
SEY-AM
RI
W
LDP
QK
LN
KYN
L
VPSD
V
IS
Q
I
KVQ
N
NQISG
GQLGG
M
P
QAADQQLNAS
I
I
V
QTR
LQT
P
EEF
GK
I
L
L
KVQQ
DG
SQ
V
L
L
R
DVA
R
VE
L
G
A
E
DYSTV
A
RY
NGK
-
P
A
A
G
IA
I
K
L
AT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAY
FP
A
S
L
K
TVYP
YDTT
PF
I
KI
SI
Q
E
VFKT
L
V
EAI
I
LV
F
LV
M
YLFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
A
I
L
S
A
V
G
F
T
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
D
KLP
P
KE
A
TH
K
SMG
QIQ
R
AL
VGIAVV
L
S
AVF
M
PM
A
F
MS
G
AT
G
E
IYR
Q
FSIT
LIS
S
M
LL
SV
F
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARF
N
TL
F
EKSTQH
----
Y
TDSTR
S
L
L
RCTGRY
M
V
VY
L
L
ICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
L
P
S
G
A
T
MVNTTKVLQ
Q
VT
DYY
LTKEKNN
V
Q
SVF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVT
AII
Q
RA
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AEL
G
TA
S
GFDME
L
LDNGNLGH
E
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
IG
V
RP
N
G
LE
DTPMFK
VNV
N
AA
KA
E
A
M
GV
A
L
S
DI
NQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
ML
P
DN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
GS
PR
L
ERY
N
GI
P
SME
I
LG
EA
AAGK
S
T
G
D
A
MKFMADLVAK
L
-
-
P
A
G
VGYS
W
T
G
--
LS
YQ
EA
L
SSNQAPA
L
Y
A
-
I
S
L
V
V
VFL
A
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LS
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
VEMM
Q
KE
----------
G
KTPV
EA
IIE
A
ARM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
VI
S
H
GAGSG
AQNA
VG
T
GVMGGM
FA
A
T
V
LAI
Y
fig|340197.3.peg.3941
Escherichia coli F11 (1-1018/1034)
M
ANFF
IRRP
IF
AWV
L
----
AI
I
L
M
M
A
G
ALA
I
LQ
LPV
A
QYP
T
I
AP
P
A
V
S
V
S
A
N
YPGA
D
AQ
T
V
Q
D
T
VT
Q
VIE
QN
M
NG
I
D
N
LM
Y
MSS
T
S
DSA
G
SVT
ITL
T
F
Q
S
GT
D
PD
I
A
QV
QVQ
NK
LQ
L
A
TPL
LP
QEVQQQ
G
I
SVE-KSSSS
---
Y
L
MVA
G
FV
S
DNPGTTQD
DI
S
D
Y
V
ASN
V
KDT
LS
RLN
GVG
D
V
QLF
G
AQY-AM
RI
W
LD
A
DL
LN
KYK
L
TPVD
V
IN
QL
KVQ
N
DQIAA
GQLGG
T
P
ALPGQQLNAS
I
I
A
QTR
L
K
N
P
EEF
GK
V
T
L
RVNS
DG
SV
V
R
L
K
DVA
R
VE
L
G
G
E
NYNVI
A
RI
NGK
-
P
A
A
G
LG
I
K
L
AT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPF
FP
Q
G
M
K
VLYP
YDTT
PF
V
QL
SI
Q
E
VVKT
L
F
EAI
M
LV
F
LV
M
YLFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
A
I
L
A
A
F
G
Y
S
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
D
KLP
P
RE
A
TE
K
SMS
QIQ
G
AL
VGIAMV
L
S
AVFIPM
A
F
FG
G
ST
G
A
IYR
Q
FSIT
IVS
AM
AL
SV
L
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWF
N
TT
F
DHSVNH
----
Y
TNSVG
K
I
L
GSTGRY
L
L
I
Y
A
L
IVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VT
DYY
LKNEKAN
V
E
SVF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
SGDENSAE
A
V
I
H
RA
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VEL
G
TA
T
GFDFE
L
IDQAGLGH
D
A
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
L
E
VD
QE
KA
Q
A
L
GVSL
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
ML
P
ED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QG
EA
APRT
S
S
G
D
A
MALMENLASK
L
-
-
P
A
G
IGYD
W
T
G
--
MS
YQ
ER
L
SGNQAPA
L
V
A
-
I
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLM
E
KE
----------
G
KGVV
EA
TLM
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
VS
A
T
LLAI
fig|340197.5.peg.4117
Escherichia coli F11 (1-1018/1034)
M
ANFF
IRRP
IF
AWV
L
----
AI
I
L
M
M
A
G
ALA
I
LQ
LPV
A
QYP
T
I
AP
P
A
V
S
V
S
A
N
YPGA
D
AQ
T
V
Q
D
T
VT
Q
VIE
QN
M
NG
I
D
N
LM
Y
MSS
T
S
DSA
G
SVT
ITL
T
F
Q
S
GT
D
PD
I
A
QV
QVQ
NK
LQ
L
A
TPL
LP
QEVQQQ
G
I
SVE-KSSSS
---
Y
L
MVA
G
FV
S
DNPGTTQD
DI
S
D
Y
V
ASN
V
KDT
LS
RLN
GVG
D
V
QLF
G
AQY-AM
RI
W
LD
A
DL
LN
KYK
L
TPVD
V
IN
QL
KVQ
N
DQIAA
GQLGG
T
P
ALPGQQLNAS
I
I
A
QTR
L
K
N
P
EEF
GK
V
T
L
RVNS
DG
SV
V
R
L
K
DVA
R
VE
L
G
G
E
NYNVI
A
RI
NGK
-
P
A
A
G
LG
I
K
L
AT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPF
FP
Q
G
M
K
VLYP
YDTT
PF
V
QL
SI
Q
E
VVKT
L
F
EAI
M
LV
F
LV
M
YLFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
A
I
L
A
A
F
G
Y
S
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
D
KLP
P
RE
A
TE
K
SMS
QIQ
G
AL
VGIAMV
L
S
AVFIPM
A
F
FG
G
ST
G
A
IYR
Q
FSIT
IVS
AM
AL
SV
L
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWF
N
TT
F
DHSVNH
----
Y
TNSVG
K
I
L
GSTGRY
L
L
I
Y
A
L
IVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VT
DYY
LKNEKAN
V
E
SVF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
SGDENSAE
A
V
I
H
RA
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VEL
G
TA
T
GFDFE
L
IDQAGLGH
D
A
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
L
E
VD
QE
KA
Q
A
L
GVSL
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
ML
P
ED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QG
EA
APRT
S
S
G
D
A
MALMENLASK
L
-
-
P
A
G
IGYD
W
T
G
--
MS
YQ
ER
L
SGNQAPA
L
V
A
-
I
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLM
E
KE
----------
G
KGVV
EA
TLM
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
VS
A
T
LLAI
fig|749550.3.peg.1298
Escherichia coli MS 200-1 (1-1018/1034)
M
ANFF
IRRP
IF
AWV
L
----
AI
I
L
M
M
A
G
ALA
I
LQ
LPV
A
QYP
T
I
AP
P
A
V
S
V
S
A
N
YPGA
D
AQ
T
V
Q
D
T
VT
Q
VIE
QN
M
NG
I
D
N
LM
Y
MSS
T
S
DSA
G
SVT
ITL
T
F
Q
S
GT
D
PD
I
A
QV
QVQ
NK
LQ
L
A
TPL
LP
QEVQQQ
G
I
SVE-KSSSS
---
Y
L
MVA
G
FV
S
DNPGTTQD
DI
S
D
Y
V
ASN
V
KDT
LS
RLN
GVG
D
V
QLF
G
AQY-AM
RI
W
LD
A
DL
LN
KYK
L
TPVD
V
IN
QL
KVQ
N
DQIAA
GQLGG
T
P
ALPGQQLNAS
I
I
A
QTR
L
K
N
P
EEF
GK
V
T
L
RVNS
DG
SV
V
R
L
K
DVA
R
VE
L
G
G
E
NYNVI
A
RI
NGK
-
P
A
A
G
LG
I
K
L
AT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPF
FP
Q
G
M
K
VLYP
YDTT
PF
V
QL
SI
Q
E
VVKT
L
F
EAI
M
LV
F
LV
M
YLFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
A
I
L
A
A
F
G
Y
S
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
D
KLP
P
RE
A
TE
K
SMS
QIQ
G
AL
VGIAMV
L
S
AVFIPM
A
F
FG
G
ST
G
A
IYR
Q
FSIT
IVS
AM
AL
SV
L
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWF
N
TT
F
DHSVNH
----
Y
TNSVG
K
I
L
GSTGRY
L
L
I
Y
A
L
IVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VT
DYY
LKNEKAN
V
E
SVF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
SGDENSAE
A
V
I
H
RA
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VEL
G
TA
T
GFDFE
L
IDQAGLGH
D
A
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
L
E
VD
QE
KA
Q
A
L
GVSL
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
ML
P
ED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QG
EA
APRT
S
S
G
D
A
MALMENLASK
L
-
-
P
A
G
IGYD
W
T
G
--
MS
YQ
ER
L
SGNQAPA
L
V
A
-
I
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLM
E
KE
----------
G
KGVV
EA
TLM
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
VS
A
T
LLAI
fig|358709.5.peg.296
Escherichia coli 101-1 (16-1018/1037)
AI
I
M
M
L
A
G
GLA
I
MN
LPV
A
QYP
Q
I
AP
P
T
I
T
V
S
A
T
YPGA
D
AQ
T
V
E
D
S
VT
Q
VIE
QN
M
NG
L
D
GLM
Y
MSS
T
S
DAA
G
NAS
ITL
T
FE
T
GT
S
PD
I
A
QV
QVQ
NK
LQ
L
A
MPS
LP
EAVQQQ
G
I
SVD-KSSSN
---
I
L
MVA
A
FI
S
DNGSLNQY
DI
A
D
Y
V
ASN
I
KDP
LS
RTA
GVG
S
V
QLF
G
SEY-AM
RI
W
LDP
QK
LN
KYN
L
VPSD
V
IS
Q
I
KVQ
N
NQISG
GQLGG
M
P
QAADQQLNAS
I
I
V
QTR
LQT
P
EEF
GK
I
L
L
KVQQ
DG
SQ
V
L
L
R
DVA
R
VE
L
G
A
E
DYSTV
A
RY
NGK
-
P
A
A
G
IA
I
K
L
AA
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAY
FP
A
S
L
K
TVYP
YDTT
PF
I
EI
SI
Q
E
VFKT
L
V
EAI
I
LV
F
LV
M
YLFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
A
I
L
S
A
V
G
F
T
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
D
KLP
P
KE
A
TH
K
SMG
QIQ
R
AL
VGIAVV
L
S
AVF
M
PM
A
F
MS
G
AT
G
E
IYR
Q
FSIT
LIS
S
M
LL
SV
F
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARF
N
TL
F
EKSTQH
----
Y
TDSTR
S
L
L
RCTGRY
M
V
VY
L
L
ICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
L
P
S
G
A
T
MVNTTKVLQ
Q
VT
DYY
LTKEKDN
V
Q
SVF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVT
AII
Q
RA
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AEL
G
TA
S
GFDME
L
LDNGNLGH
E
K
L
TQARN
E
L
LLL
A
AQS
P
NQ
V
TG
V
RP
N
G
LE
DTPMFK
VNV
N
AA
KA
E
A
M
GV
A
L
S
DI
NQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
ML
P
DN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
GS
PR
L
ERY
N
GI
P
SME
I
LG
EA
AAGK
S
T
G
D
A
MKFMADLVAK
L
-
-
P
A
G
VGYS
W
T
G
--
LS
YQ
EA
L
SSNQAPA
L
Y
A
-
I
S
L
V
V
VFL
A
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LS
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
VEMM
Q
KE
----------
G
KTPI
EA
IIE
A
ARM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
VI
S
H
GAGSG
AQNA
VG
T
GVMGGM
FA
A
T
V
LAI
Y
fig|869729.3.peg.3796
Escherichia coli UM146 (16-1018/1037)
AI
I
M
M
L
A
G
GLA
I
MN
LPV
A
QYP
Q
I
AP
P
T
I
T
I
S
A
T
YPGA
D
AQ
T
V
E
D
S
VT
Q
VIE
QN
M
NG
L
D
GLM
Y
MSS
T
S
DAA
G
NAS
ITL
T
FE
T
GT
S
PD
I
A
QV
QVQ
NK
LQ
L
A
MPS
LP
EAVQQQ
G
I
SVD-KSSSN
---
I
L
MVA
A
FI
S
DNGSLNQY
DI
A
D
Y
V
ASN
I
KDP
LS
RTA
GVG
S
V
QLF
G
SEY-AM
RI
W
LDP
QK
LN
KYN
L
VPSD
V
IS
Q
I
KVQ
N
NQISG
GQLGG
M
P
QAADQQLNAS
I
I
V
QTR
LQT
P
EEF
GK
I
L
L
KVQQ
DG
SQ
V
L
L
R
DVA
R
VE
L
G
A
E
DYSTV
A
RY
NGK
-
P
A
A
G
IA
I
K
L
AT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAY
FP
A
S
L
K
TIYP
YDTT
PF
I
KI
SI
Q
E
VFKT
L
V
EAI
I
LV
F
LV
M
YLFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
A
I
L
S
A
V
G
F
T
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
D
KLP
P
KE
A
TH
K
SMG
QIQ
R
AL
VGIAVV
L
S
AVF
M
PM
A
F
MS
G
AT
G
E
IYR
Q
FSIT
LIS
S
M
LL
SV
F
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARF
N
TL
F
EKSTQH
----
Y
TDSTR
S
L
L
RCTGRY
M
V
VY
L
L
ICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
L
P
S
G
A
T
MVNTTKVLQ
Q
VT
DYY
LTKEKNN
V
Q
SVF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVT
AII
Q
RA
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AEL
G
TA
S
GFDME
L
LDNGNLGH
E
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
IG
V
RP
N
G
LE
DTPMFK
VNV
N
AA
KA
E
A
M
GV
A
L
S
DI
NQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
ML
P
DN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
GS
PR
L
ERY
N
GI
P
SME
I
LG
EA
AAGK
S
T
G
D
A
MKFMADLVAK
L
-
-
P
A
G
VGYS
W
T
G
--
LS
YQ
EA
L
SSNQAPA
L
Y
A
-
I
S
L
V
V
VFL
A
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LS
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
VEMM
Q
KE
----------
G
KTPV
EA
IIE
A
ARM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
VI
S
H
GAGSG
AQNA
VG
T
GVMGGM
FA
A
T
V
LAI
Y
fig|364106.7.peg.3957
Escherichia coli UTI89 (16-1018/1037)
AI
I
M
M
L
A
G
GLA
I
MN
LPV
A
QYP
Q
I
AP
P
T
I
T
I
S
A
T
YPGA
D
AQ
T
V
E
D
S
VT
Q
VIE
QN
M
NG
L
D
GLM
Y
MSS
T
S
DAA
G
NAS
ITL
T
FE
T
GT
S
PD
I
A
QV
QVQ
NK
LQ
L
A
MPS
LP
EAVQQQ
G
I
SVD-KSSSN
---
I
L
MVA
A
FI
S
DNGSLNQY
DI
A
D
Y
V
ASN
I
KDP
LS
RTA
GVG
S
V
QLF
G
SEY-AM
RI
W
LDP
QK
LN
KYN
L
VPSD
V
IS
Q
I
KVQ
N
NQISG
GQLGG
M
P
QAADQQLNAS
I
I
V
QTR
LQT
P
EEF
GK
I
L
L
KVQQ
DG
SQ
V
L
L
R
DVA
R
VE
L
G
A
E
DYSTV
A
RY
NGK
-
P
A
A
G
IA
I
K
L
AT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAY
FP
A
S
L
K
TIYP
YDTT
PF
I
KI
SI
Q
E
VFKT
L
V
EAI
I
LV
F
LV
M
YLFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
A
I
L
S
A
V
G
F
T
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
D
KLP
P
KE
A
TH
K
SMG
QIQ
R
AL
VGIAVV
L
S
AVF
M
PM
A
F
MS
G
AT
G
E
IYR
Q
FSIT
LIS
S
M
LL
SV
F
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARF
N
TL
F
EKSTQH
----
Y
TDSTR
S
L
L
RCTGRY
M
V
VY
L
L
ICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
L
P
S
G
A
T
MVNTTKVLQ
Q
VT
DYY
LTKEKNN
V
Q
SVF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVT
AII
Q
RA
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AEL
G
TA
S
GFDME
L
LDNGNLGH
E
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
IG
V
RP
N
G
LE
DTPMFK
VNV
N
AA
KA
E
A
M
GV
A
L
S
DI
NQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
ML
P
DN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
GS
PR
L
ERY
N
GI
P
SME
I
LG
EA
AAGK
S
T
G
D
A
MKFMADLVAK
L
-
-
P
A
G
VGYS
W
T
G
--
LS
YQ
EA
L
SSNQAPA
L
Y
A
-
I
S
L
V
V
VFL
A
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LS
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
VEMM
Q
KE
----------
G
KTPV
EA
IIE
A
ARM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
VI
S
H
GAGSG
AQNA
VG
T
GVMGGM
FA
A
T
V
LAI
Y
fig|364106.8.peg.3958
Escherichia coli UTI89 (16-1018/1037)
AI
I
M
M
L
A
G
GLA
I
MN
LPV
A
QYP
Q
I
AP
P
T
I
T
I
S
A
T
YPGA
D
AQ
T
V
E
D
S
VT
Q
VIE
QN
M
NG
L
D
GLM
Y
MSS
T
S
DAA
G
NAS
ITL
T
FE
T
GT
S
PD
I
A
QV
QVQ
NK
LQ
L
A
MPS
LP
EAVQQQ
G
I
SVD-KSSSN
---
I
L
MVA
A
FI
S
DNGSLNQY
DI
A
D
Y
V
ASN
I
KDP
LS
RTA
GVG
S
V
QLF
G
SEY-AM
RI
W
LDP
QK
LN
KYN
L
VPSD
V
IS
Q
I
KVQ
N
NQISG
GQLGG
M
P
QAADQQLNAS
I
I
V
QTR
LQT
P
EEF
GK
I
L
L
KVQQ
DG
SQ
V
L
L
R
DVA
R
VE
L
G
A
E
DYSTV
A
RY
NGK
-
P
A
A
G
IA
I
K
L
AT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAY
FP
A
S
L
K
TIYP
YDTT
PF
I
KI
SI
Q
E
VFKT
L
V
EAI
I
LV
F
LV
M
YLFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
A
I
L
S
A
V
G
F
T
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
D
KLP
P
KE
A
TH
K
SMG
QIQ
R
AL
VGIAVV
L
S
AVF
M
PM
A
F
MS
G
AT
G
E
IYR
Q
FSIT
LIS
S
M
LL
SV
F
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARF
N
TL
F
EKSTQH
----
Y
TDSTR
S
L
L
RCTGRY
M
V
VY
L
L
ICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
L
P
S
G
A
T
MVNTTKVLQ
Q
VT
DYY
LTKEKNN
V
Q
SVF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVT
AII
Q
RA
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AEL
G
TA
S
GFDME
L
LDNGNLGH
E
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
IG
V
RP
N
G
LE
DTPMFK
VNV
N
AA
KA
E
A
M
GV
A
L
S
DI
NQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
ML
P
DN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
GS
PR
L
ERY
N
GI
P
SME
I
LG
EA
AAGK
S
T
G
D
A
MKFMADLVAK
L
-
-
P
A
G
VGYS
W
T
G
--
LS
YQ
EA
L
SSNQAPA
L
Y
A
-
I
S
L
V
V
VFL
A
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LS
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
VEMM
Q
KE
----------
G
KTPV
EA
IIE
A
ARM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
VI
S
H
GAGSG
AQNA
VG
T
GVMGGM
FA
A
T
V
LAI
Y
fig|362663.8.peg.3389
Escherichia coli 536 (1-1018/1034)
M
ANFF
IRRP
IF
AWV
L
----
AI
I
L
M
M
A
G
ALA
I
LQ
LPV
A
QYP
T
I
AP
P
A
V
S
V
S
A
N
YPGA
D
AQ
T
V
Q
D
T
VT
Q
VIE
QN
M
NG
I
D
N
LM
Y
MSS
T
S
DSA
G
SVT
ITL
T
F
Q
S
GT
D
PD
I
A
QV
QVQ
NK
LQ
L
A
TPL
LP
QEVQQQ
G
I
SVE-KSSSS
---
Y
L
MVP
G
FV
S
DNPGTTQD
DI
S
D
Y
V
ASN
V
KDT
LS
RLN
GVG
D
V
QLF
G
AQY-AM
RI
W
LD
A
DL
LN
KYK
L
TPVD
V
IN
QL
KVQ
N
DQIAA
GQLGG
T
P
ALPGQQLNAS
I
I
A
QTR
L
K
N
P
EEF
GK
V
T
L
RVNS
DG
SV
V
R
L
K
DVA
R
VE
L
G
G
E
NYNVI
A
RI
NGK
-
P
A
A
G
LG
I
K
L
AT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPF
FP
Q
G
M
K
VLYP
YDTT
PF
V
QL
SI
Q
E
VVKT
L
F
EAI
M
LV
F
LV
M
YLFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
A
I
L
A
A
F
G
Y
S
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
D
KLP
P
RE
A
TE
K
SMS
QIQ
G
AL
VGIAMV
L
S
AVFIPM
A
F
FG
G
ST
G
A
IYR
Q
FSIT
IVS
AM
AL
SV
L
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWF
N
TT
F
DHSVNH
----
Y
TNSVG
K
I
L
GSTGRY
L
L
I
Y
A
L
IVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VT
DYY
LKNEKAN
V
E
SVF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
SGDENSAE
A
V
I
H
RA
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VEL
G
TA
T
GFDFE
L
IDQAGLGH
D
A
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
L
E
VD
QE
KA
Q
A
L
GVSL
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
ML
P
ED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QG
EA
APRT
S
S
G
D
A
MALMENLASK
L
-
-
P
A
G
IGYD
W
T
G
--
MS
YQ
ER
L
SGNQAPA
L
V
A
-
I
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLM
E
KE
----------
G
KGVV
EA
TLM
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
VS
A
T
LLAI
fig|362663.9.peg.3401
Escherichia coli 536 (1-1018/1034)
M
ANFF
IRRP
IF
AWV
L
----
AI
I
L
M
M
A
G
ALA
I
LQ
LPV
A
QYP
T
I
AP
P
A
V
S
V
S
A
N
YPGA
D
AQ
T
V
Q
D
T
VT
Q
VIE
QN
M
NG
I
D
N
LM
Y
MSS
T
S
DSA
G
SVT
ITL
T
F
Q
S
GT
D
PD
I
A
QV
QVQ
NK
LQ
L
A
TPL
LP
QEVQQQ
G
I
SVE-KSSSS
---
Y
L
MVP
G
FV
S
DNPGTTQD
DI
S
D
Y
V
ASN
V
KDT
LS
RLN
GVG
D
V
QLF
G
AQY-AM
RI
W
LD
A
DL
LN
KYK
L
TPVD
V
IN
QL
KVQ
N
DQIAA
GQLGG
T
P
ALPGQQLNAS
I
I
A
QTR
L
K
N
P
EEF
GK
V
T
L
RVNS
DG
SV
V
R
L
K
DVA
R
VE
L
G
G
E
NYNVI
A
RI
NGK
-
P
A
A
G
LG
I
K
L
AT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPF
FP
Q
G
M
K
VLYP
YDTT
PF
V
QL
SI
Q
E
VVKT
L
F
EAI
M
LV
F
LV
M
YLFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
A
I
L
A
A
F
G
Y
S
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
D
KLP
P
RE
A
TE
K
SMS
QIQ
G
AL
VGIAMV
L
S
AVFIPM
A
F
FG
G
ST
G
A
IYR
Q
FSIT
IVS
AM
AL
SV
L
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWF
N
TT
F
DHSVNH
----
Y
TNSVG
K
I
L
GSTGRY
L
L
I
Y
A
L
IVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VT
DYY
LKNEKAN
V
E
SVF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
SGDENSAE
A
V
I
H
RA
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VEL
G
TA
T
GFDFE
L
IDQAGLGH
D
A
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
L
E
VD
QE
KA
Q
A
L
GVSL
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
ML
P
ED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QG
EA
APRT
S
S
G
D
A
MALMENLASK
L
-
-
P
A
G
IGYD
W
T
G
--
MS
YQ
ER
L
SGNQAPA
L
V
A
-
I
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLM
E
KE
----------
G
KGVV
EA
TLM
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
VS
A
T
LLAI
fig|525281.3.peg.2964
Escherichia coli 83972 (16-1018/1037)
AI
I
M
M
L
A
G
GLA
I
MN
LPV
A
QYP
Q
I
AP
P
T
I
T
V
S
A
T
YPGA
D
AQ
T
V
E
D
S
VT
Q
VIE
QN
M
NG
L
D
GLM
Y
MSS
T
S
DAA
G
NAS
ITL
T
FE
T
GT
S
PD
I
A
QV
QVQ
NK
LQ
L
A
MPS
LP
EAVQQQ
G
I
SVD-KSSSN
---
I
L
MVA
A
FI
S
DNGSLNQY
DI
A
D
Y
V
ASN
I
KDP
LS
RTA
GVG
S
V
QLF
G
SEY-AM
RI
W
LDP
QK
LN
KYN
L
VPSD
V
IS
Q
I
KVQ
N
NQISG
GQLGG
M
P
QAADQQLNAS
I
I
V
QTR
LQT
P
EEF
GK
I
L
L
KVQQ
DG
SQ
V
L
L
R
DVA
R
VE
L
G
A
E
DYSTV
A
RY
NGK
-
P
A
A
G
IA
I
K
L
AT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAY
FP
A
S
L
K
TVYP
YDTT
PF
I
KI
SI
Q
E
VFKT
L
V
EAI
I
LV
F
LV
M
YLFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
A
I
L
S
A
V
G
F
T
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
D
KLP
P
KE
A
TH
K
SMG
QIQ
R
AL
VGIAVV
L
S
AVF
M
PM
A
F
MS
G
AT
G
E
IYR
Q
FSIT
LIS
S
M
LL
SV
F
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARF
N
TL
F
EKSTQH
----
Y
TDSTR
S
L
L
RCTGRY
M
V
VY
L
L
ICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
L
P
S
G
A
T
MVNTTKVLQ
Q
VT
DYY
LTKEKNN
V
Q
SVF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVT
AII
Q
RA
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AEL
G
TA
S
GFDME
L
LDNGNLGH
E
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
IG
V
RP
N
G
LE
DTPMFK
VNV
N
AA
KA
E
A
M
GV
A
L
S
DI
NQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
ML
P
DN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
GS
PR
L
ERY
N
GI
P
SME
I
LG
EA
AAGK
S
T
G
D
A
MKFMADLVAK
L
-
-
P
A
G
VGYS
W
T
G
--
LS
YQ
EA
L
SSNQAPA
L
Y
A
-
I
S
L
V
V
VFL
A
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LS
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
VEMM
Q
KE
----------
G
KTPV
EA
IIE
A
ARM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
VI
S
H
GAGSG
AQNA
VG
T
GVMGGM
FA
A
T
V
LAI
Y
fig|655817.3.peg.4126
Escherichia coli ABU 83972 (16-1018/1037)
AI
I
M
M
L
A
G
GLA
I
MN
LPV
A
QYP
Q
I
AP
P
T
I
T
V
S
A
T
YPGA
D
AQ
T
V
E
D
S
VT
Q
VIE
QN
M
NG
L
D
GLM
Y
MSS
T
S
DAA
G
NAS
ITL
T
FE
T
GT
S
PD
I
A
QV
QVQ
NK
LQ
L
A
MPS
LP
EAVQQQ
G
I
SVD-KSSSN
---
I
L
MVA
A
FI
S
DNGSLNQY
DI
A
D
Y
V
ASN
I
KDP
LS
RTA
GVG
S
V
QLF
G
SEY-AM
RI
W
LDP
QK
LN
KYN
L
VPSD
V
IS
Q
I
KVQ
N
NQISG
GQLGG
M
P
QAADQQLNAS
I
I
V
QTR
LQT
P
EEF
GK
I
L
L
KVQQ
DG
SQ
V
L
L
R
DVA
R
VE
L
G
A
E
DYSTV
A
RY
NGK
-
P
A
A
G
IA
I
K
L
AT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAY
FP
A
S
L
K
TVYP
YDTT
PF
I
KI
SI
Q
E
VFKT
L
V
EAI
I
LV
F
LV
M
YLFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
A
I
L
S
A
V
G
F
T
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
D
KLP
P
KE
A
TH
K
SMG
QIQ
R
AL
VGIAVV
L
S
AVF
M
PM
A
F
MS
G
AT
G
E
IYR
Q
FSIT
LIS
S
M
LL
SV
F
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARF
N
TL
F
EKSTQH
----
Y
TDSTR
S
L
L
RCTGRY
M
V
VY
L
L
ICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
L
P
S
G
A
T
MVNTTKVLQ
Q
VT
DYY
LTKEKNN
V
Q
SVF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVT
AII
Q
RA
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AEL
G
TA
S
GFDME
L
LDNGNLGH
E
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
IG
V
RP
N
G
LE
DTPMFK
VNV
N
AA
KA
E
A
M
GV
A
L
S
DI
NQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
ML
P
DN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
GS
PR
L
ERY
N
GI
P
SME
I
LG
EA
AAGK
S
T
G
D
A
MKFMADLVAK
L
-
-
P
A
G
VGYS
W
T
G
--
LS
YQ
EA
L
SSNQAPA
L
Y
A
-
I
S
L
V
V
VFL
A
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LS
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
VEMM
Q
KE
----------
G
KTPV
EA
IIE
A
ARM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
VI
S
H
GAGSG
AQNA
VG
T
GVMGGM
FA
A
T
V
LAI
Y
fig|199310.1.peg.4230
Escherichia coli CFT073 (16-1018/1037)
AI
I
M
M
L
A
G
GLA
I
MN
LPV
A
QYP
Q
I
AP
P
T
I
T
V
S
A
T
YPGA
D
AQ
T
V
E
D
S
VT
Q
VIE
QN
M
NG
L
D
GLM
Y
MSS
T
S
DAA
G
NAS
ITL
T
FE
T
GT
S
PD
I
A
QV
QVQ
NK
LQ
L
A
MPS
LP
EAVQQQ
G
I
SVD-KSSSN
---
I
L
MVA
A
FI
S
DNGSLNQY
DI
A
D
Y
V
ASN
I
KDP
LS
RTA
GVG
S
V
QLF
G
SEY-AM
RI
W
LDP
QK
LN
KYN
L
VPSD
V
IS
Q
I
KVQ
N
NQISG
GQLGG
M
P
QAADQQLNAS
I
I
V
QTR
LQT
P
EEF
GK
I
L
L
KVQQ
DG
SQ
V
L
L
R
DVA
R
VE
L
G
A
E
DYSTV
A
RY
NGK
-
P
A
A
G
IA
I
K
L
AT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAY
FP
A
S
L
K
TVYP
YDTT
PF
I
KI
SI
Q
E
VFKT
L
V
EAI
I
LV
F
LV
M
YLFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
A
I
L
S
A
V
G
F
T
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
D
KLP
P
KE
A
TH
K
SMG
QIQ
R
AL
VGIAVV
L
S
AVF
M
PM
A
F
MS
G
AT
G
E
IYR
Q
FSIT
LIS
S
M
LL
SV
F
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARF
N
TL
F
EKSTQH
----
Y
TDSTR
S
L
L
RCTGRY
M
V
VY
L
L
ICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
L
P
S
G
A
T
MVNTTKVLQ
Q
VT
DYY
LTKEKNN
V
Q
SVF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVT
AII
Q
RA
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AEL
G
TA
S
GFDME
L
LDNGNLGH
E
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
IG
V
RP
N
G
LE
DTPMFK
VNV
N
AA
KA
E
A
M
GV
A
L
S
DI
NQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
ML
P
DN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
GS
PR
L
ERY
N
GI
P
SME
I
LG
EA
AAGK
S
T
G
D
A
MKFMADLVAK
L
-
-
P
A
G
VGYS
W
T
G
--
LS
YQ
EA
L
SSNQAPA
L
Y
A
-
I
S
L
V
V
VFL
A
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LS
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
VEMM
Q
KE
----------
G
KTPV
EA
IIE
A
ARM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
VI
S
H
GAGSG
AQNA
VG
T
GVMGGM
FA
A
T
V
LAI
Y
fig|199310.4.peg.4061
Escherichia coli CFT073 (16-1018/1037)
AI
I
M
M
L
A
G
GLA
I
MN
LPV
A
QYP
Q
I
AP
P
T
I
T
V
S
A
T
YPGA
D
AQ
T
V
E
D
S
VT
Q
VIE
QN
M
NG
L
D
GLM
Y
MSS
T
S
DAA
G
NAS
ITL
T
FE
T
GT
S
PD
I
A
QV
QVQ
NK
LQ
L
A
MPS
LP
EAVQQQ
G
I
SVD-KSSSN
---
I
L
MVA
A
FI
S
DNGSLNQY
DI
A
D
Y
V
ASN
I
KDP
LS
RTA
GVG
S
V
QLF
G
SEY-AM
RI
W
LDP
QK
LN
KYN
L
VPSD
V
IS
Q
I
KVQ
N
NQISG
GQLGG
M
P
QAADQQLNAS
I
I
V
QTR
LQT
P
EEF
GK
I
L
L
KVQQ
DG
SQ
V
L
L
R
DVA
R
VE
L
G
A
E
DYSTV
A
RY
NGK
-
P
A
A
G
IA
I
K
L
AT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAY
FP
A
S
L
K
TVYP
YDTT
PF
I
KI
SI
Q
E
VFKT
L
V
EAI
I
LV
F
LV
M
YLFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
A
I
L
S
A
V
G
F
T
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
D
KLP
P
KE
A
TH
K
SMG
QIQ
R
AL
VGIAVV
L
S
AVF
M
PM
A
F
MS
G
AT
G
E
IYR
Q
FSIT
LIS
S
M
LL
SV
F
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARF
N
TL
F
EKSTQH
----
Y
TDSTR
S
L
L
RCTGRY
M
V
VY
L
L
ICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
L
P
S
G
A
T
MVNTTKVLQ
Q
VT
DYY
LTKEKNN
V
Q
SVF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVT
AII
Q
RA
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AEL
G
TA
S
GFDME
L
LDNGNLGH
E
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
IG
V
RP
N
G
LE
DTPMFK
VNV
N
AA
KA
E
A
M
GV
A
L
S
DI
NQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
ML
P
DN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
GS
PR
L
ERY
N
GI
P
SME
I
LG
EA
AAGK
S
T
G
D
A
MKFMADLVAK
L
-
-
P
A
G
VGYS
W
T
G
--
LS
YQ
EA
L
SSNQAPA
L
Y
A
-
I
S
L
V
V
VFL
A
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LS
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
VEMM
Q
KE
----------
G
KTPV
EA
IIE
A
ARM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
VI
S
H
GAGSG
AQNA
VG
T
GVMGGM
FA
A
T
V
LAI
Y
fig|749528.3.peg.2997
Escherichia coli MS 45-1 (16-1018/1037)
AI
I
M
M
L
A
G
GLA
I
MN
LPV
A
QYP
Q
I
AP
P
T
I
T
V
S
A
T
YPGA
D
AQ
T
V
E
D
S
VT
Q
VIE
QN
M
NG
L
D
GLM
Y
MSS
T
S
DAA
G
NAS
ITL
T
FE
T
GT
S
PD
I
A
QV
QVQ
NK
LQ
L
A
MPS
LP
EAVQQQ
G
I
SVD-KSSSN
---
I
L
MVA
A
FI
S
DNGSLNQY
DI
A
D
Y
V
ASN
I
KDP
LS
RTA
GVG
S
V
QLF
G
SEY-AM
RI
W
LDP
QK
LN
KYN
L
VPSD
V
IS
Q
I
KVQ
N
NQISG
GQLGG
M
P
QAADQQLNAS
I
I
V
QTR
LQT
P
EEF
GK
I
L
L
KVQQ
DG
SQ
V
L
L
R
DVA
R
VE
L
G
A
E
DYSTV
A
RY
NGK
-
P
A
A
G
IA
I
K
L
AT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAY
FP
A
S
L
K
TVYP
YDTT
PF
I
KI
SI
Q
E
VFKT
L
V
EAI
I
LV
F
LV
M
YLFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
A
I
L
S
A
V
G
F
T
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
D
KLP
P
KE
A
TH
K
SMG
QIQ
R
AL
VGIAVV
L
S
AVF
M
PM
A
F
MS
G
AT
G
E
IYR
Q
FSIT
LIS
S
M
LL
SV
F
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARF
N
TL
F
EKSTQH
----
Y
TDSTR
S
L
L
RCTGRY
M
V
VY
L
L
ICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
L
P
S
G
A
T
MVNTTKVLQ
Q
VT
DYY
LTKEKNN
V
Q
SVF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVT
AII
Q
RA
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AEL
G
TA
S
GFDME
L
LDNGNLGH
E
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
IG
V
RP
N
G
LE
DTPMFK
VNV
N
AA
KA
E
A
M
GV
A
L
S
DI
NQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
ML
P
DN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
GS
PR
L
ERY
N
GI
P
SME
I
LG
EA
AAGK
S
T
G
D
A
MKFMADLVAK
L
-
-
P
A
G
VGYS
W
T
G
--
LS
YQ
EA
L
SSNQAPA
L
Y
A
-
I
S
L
V
V
VFL
A
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LS
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
VEMM
Q
KE
----------
G
KTPV
EA
IIE
A
ARM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
VI
S
H
GAGSG
AQNA
VG
T
GVMGGM
FA
A
T
V
LAI
Y
fig|585057.4.peg.4149
Escherichia coli IAI39 (16-1018/1037)
AI
I
M
M
L
A
G
GLA
I
MN
LPV
A
QYP
Q
I
AP
P
T
I
T
V
S
A
T
YPGA
D
AQ
T
V
E
D
S
VT
Q
VIE
QN
M
NG
L
D
GLM
Y
MSS
T
S
DAA
G
NAS
ITL
T
FE
T
GT
S
PD
I
A
QV
QVQ
NK
LQ
L
A
MPS
LP
EAVQQQ
G
I
SVD-KSSSN
---
I
L
MVA
A
FI
S
DNGSLNQY
DI
A
D
Y
V
ASN
I
KDP
LS
RTA
GVG
S
V
QLF
G
SEY-AM
RI
W
LDP
QK
LN
KYN
L
VPSD
V
IS
Q
I
KVQ
N
NQISG
GQLGG
M
P
QAADQQLNAS
I
I
V
QTR
LQT
P
EEF
GK
I
L
L
KVQQ
DG
SQ
V
L
L
R
DVA
R
VE
L
G
A
E
DYSTV
A
RY
NGK
-
P
A
A
G
IA
I
K
L
AT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAY
FP
A
S
L
K
TVYP
YDTT
PF
I
KI
SI
Q
E
VFKT
L
V
EAI
I
LV
F
LV
M
YLFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
A
I
L
S
A
V
G
F
T
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
D
KLP
P
KE
A
TH
K
SMG
QIQ
R
AL
VGIAVV
L
S
AVF
M
PM
A
F
MS
G
AT
G
E
IYR
Q
FSIT
LIS
S
M
LL
SV
F
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARF
N
TL
F
EKSTQH
----
Y
TDSTR
S
L
L
RCTGRY
M
V
VY
L
L
ICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
L
P
S
G
A
T
MVNTTKVLQ
Q
VT
DYY
LTKEKNN
V
Q
SVF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVT
AII
Q
RA
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AEL
G
TA
S
GFDME
L
LDNGNLGH
E
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
IG
V
RP
N
G
LE
DTPMFK
VNV
N
AA
KA
E
A
M
GV
A
L
S
DI
NQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
ML
P
DN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
GS
PR
L
ERY
N
GI
P
SME
I
LG
EA
AAGK
S
T
G
D
A
MKFMADLVAK
L
-
-
P
A
G
VGYS
W
T
G
--
LS
YQ
EA
L
SSNQAPA
L
Y
A
-
I
S
L
V
V
VFL
A
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LS
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
VEMM
Q
KE
----------
G
KTPI
EA
IIE
A
ARM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
VI
S
H
GAGSG
AQNA
VG
T
GVMGGM
FA
A
T
V
LAI
Y
fig|585057.6.peg.4157
Escherichia coli IAI39 (16-1018/1037)
AI
I
M
M
L
A
G
GLA
I
MN
LPV
A
QYP
Q
I
AP
P
T
I
T
V
S
A
T
YPGA
D
AQ
T
V
E
D
S
VT
Q
VIE
QN
M
NG
L
D
GLM
Y
MSS
T
S
DAA
G
NAS
ITL
T
FE
T
GT
S
PD
I
A
QV
QVQ
NK
LQ
L
A
MPS
LP
EAVQQQ
G
I
SVD-KSSSN
---
I
L
MVA
A
FI
S
DNGSLNQY
DI
A
D
Y
V
ASN
I
KDP
LS
RTA
GVG
S
V
QLF
G
SEY-AM
RI
W
LDP
QK
LN
KYN
L
VPSD
V
IS
Q
I
KVQ
N
NQISG
GQLGG
M
P
QAADQQLNAS
I
I
V
QTR
LQT
P
EEF
GK
I
L
L
KVQQ
DG
SQ
V
L
L
R
DVA
R
VE
L
G
A
E
DYSTV
A
RY
NGK
-
P
A
A
G
IA
I
K
L
AT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAY
FP
A
S
L
K
TVYP
YDTT
PF
I
KI
SI
Q
E
VFKT
L
V
EAI
I
LV
F
LV
M
YLFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
A
I
L
S
A
V
G
F
T
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
D
KLP
P
KE
A
TH
K
SMG
QIQ
R
AL
VGIAVV
L
S
AVF
M
PM
A
F
MS
G
AT
G
E
IYR
Q
FSIT
LIS
S
M
LL
SV
F
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARF
N
TL
F
EKSTQH
----
Y
TDSTR
S
L
L
RCTGRY
M
V
VY
L
L
ICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
L
P
S
G
A
T
MVNTTKVLQ
Q
VT
DYY
LTKEKNN
V
Q
SVF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVT
AII
Q
RA
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AEL
G
TA
S
GFDME
L
LDNGNLGH
E
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
IG
V
RP
N
G
LE
DTPMFK
VNV
N
AA
KA
E
A
M
GV
A
L
S
DI
NQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
ML
P
DN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
GS
PR
L
ERY
N
GI
P
SME
I
LG
EA
AAGK
S
T
G
D
A
MKFMADLVAK
L
-
-
P
A
G
VGYS
W
T
G
--
LS
YQ
EA
L
SSNQAPA
L
Y
A
-
I
S
L
V
V
VFL
A
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LS
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
VEMM
Q
KE
----------
G
KTPI
EA
IIE
A
ARM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
VI
S
H
GAGSG
AQNA
VG
T
GVMGGM
FA
A
T
V
LAI
Y
fig|749527.3.peg.4640
Escherichia coli MS 21-1 (16-1018/1037)
AI
I
M
M
L
A
G
GLA
I
MN
LPV
A
QYP
Q
I
AP
P
T
I
T
V
S
A
T
YPGA
D
AQ
T
V
E
D
S
VT
Q
VIE
QN
M
NG
L
D
GLM
Y
MSS
T
S
DAA
G
NAS
ITL
T
FE
T
GT
S
PD
I
A
QV
QVQ
NK
LQ
L
A
MPS
LP
EAVQQQ
G
I
SVD-KSSSN
---
I
L
MVA
A
FI
S
DNGSLNQY
DI
A
D
Y
V
ASN
I
KDP
LS
RTA
GVG
S
V
QLF
G
SEY-AM
RI
W
LDP
QK
LN
KYN
L
VPSD
V
IS
Q
I
KVQ
N
NQISG
GQLGG
M
P
QAADQQLNAS
I
I
V
QTR
LQT
P
EEF
GK
I
L
L
KVQQ
DG
SQ
V
L
L
R
DVA
R
VE
L
G
A
E
DYSTV
A
RY
NGK
-
P
A
A
G
IA
I
K
L
AT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAY
FP
A
S
L
K
TVYP
YDTT
PF
I
KI
SI
Q
E
VFKT
L
V
EAI
I
LV
F
LV
M
YLFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
A
I
L
S
A
V
G
F
T
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
D
KLP
P
KE
A
TH
K
SMG
QIQ
R
AL
VGIAVV
L
S
AVF
M
PM
A
F
MS
G
AT
G
E
IYR
Q
FSIT
LIS
S
M
LL
SV
F
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARF
N
TL
F
EKSTQH
----
Y
TDSTR
S
L
L
RCTGRY
M
V
VY
L
L
ICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
L
P
S
G
A
T
MVNTTKVLQ
Q
VT
DYY
LTKEKNN
V
Q
SVF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVT
AII
Q
RA
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AEL
G
TA
S
GFDME
L
LDNGNLGH
E
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
IG
V
RP
N
G
LE
DTPMFK
VNV
N
AA
KA
E
A
M
GV
A
L
S
DI
NQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
ML
P
DN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
GS
PR
L
ERY
N
GI
P
SME
I
LG
EA
AAGK
S
T
G
D
A
MKFMADLVAK
L
-
-
P
A
G
VGYS
W
T
G
--
LS
YQ
EA
L
SSNQAPA
L
Y
A
-
I
S
L
V
V
VFL
A
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LS
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
VEMM
Q
KE
----------
G
KTPI
EA
IIE
A
ARM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
VI
S
H
GAGSG
AQNA
VG
T
GVMGGM
FA
A
T
V
LAI
Y
fig|656393.3.peg.4588
Escherichia coli H299 (16-1018/1037)
AI
I
M
M
L
A
G
GLA
I
MN
LPV
A
QYP
Q
I
AP
P
T
I
T
V
S
A
T
YPGA
D
AQ
T
V
E
D
S
VT
Q
VIE
QN
M
NG
L
D
GLM
Y
MSS
T
S
DAA
G
NAS
ITL
T
FE
T
GT
S
PD
I
A
QV
QVQ
NK
LQ
L
A
MPS
LP
EAVQQQ
G
I
SVD-KSSSN
---
I
L
MVA
A
FI
S
DNGSLNQY
DI
A
D
Y
V
ASN
I
KDP
LS
RTA
GVG
S
V
QLF
G
SEY-AM
RI
W
LDP
QK
LN
KYN
L
VPSD
V
IS
Q
I
KVQ
N
NQISG
GQLGG
M
P
QAADQQLNAS
I
I
V
QTR
LQT
P
EEF
GK
I
L
L
KVQQ
DG
SQ
V
L
L
R
DVA
R
VE
L
G
A
E
DYSTV
A
RY
NGK
-
P
A
A
G
IA
I
K
L
AA
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAY
FP
A
S
L
K
TVYP
YDTT
PF
I
KI
SI
Q
E
VFKT
L
V
EAI
I
LV
F
LV
M
YLFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
A
I
L
S
A
V
G
F
T
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
D
KLP
P
KE
A
TH
K
SMG
QIQ
R
AL
VGIAVV
L
S
AVF
M
PM
A
F
MS
G
AT
G
E
IYR
Q
FSIT
LIS
S
M
LL
SV
F
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARF
N
TL
F
EKSTQH
----
Y
TDSTR
S
L
L
RCTGRY
M
V
VY
L
L
ICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
L
P
S
G
A
T
MVNTTKVLQ
Q
VT
DYY
LTKEKDN
V
Q
SVF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVT
AII
Q
RA
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AEL
G
TA
S
GFDME
L
LDNGNLGH
E
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
IG
V
RP
N
G
LE
DTPMFK
VNV
N
AA
KA
E
A
M
GV
A
L
S
DI
NQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
ML
P
DN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
GS
PR
L
ERY
N
GI
P
SME
I
LG
EA
AAGK
S
T
G
D
A
MKFMADLVAK
L
-
-
P
A
G
VGYS
W
T
G
--
LS
YQ
EA
L
SSNQAPA
L
Y
A
-
I
S
L
V
V
VFL
A
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
VG
A
L
M
A
TDLR
G
LS
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
VEMM
Q
KE
----------
G
KTPI
EA
IIE
A
ARM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
VI
S
H
GAGSG
AQNA
VG
T
GVMGGM
FA
A
T
V
LAI
Y
fig|749532.3.peg.4103
Escherichia coli MS 78-1 (17-1021/1040)
I
M
RPVA
TTL
L
----
M
V
A
I
L
L
A
G
IIG
Y
RA
LPV
S
AL
P
E
V
DY
P
T
I
Q
V
V
T
L
Y
S
GA
S
PD
V
M
T
S
A
VT
A
PL
E
RQ
F
GQ
M
S
GL
K
Q
MSS
Q
S
SG-
G
ASV
ITL
Q
F
Q
L
TL
P
L
D
V
A
EQ
E
VQ
AA
IN
A
A
TNL
LP
SDLPNP
P
V
YSKVNPADP
---
P
I
MTL
A
VT
S
T--AMPMT
Q
V
E
D
M
V
ETR
V
AQK
I
S
QIS
GVG
L
V
TLS
G
GQRPAV
R
V
K
L
NA
QA
IA
ALG
L
TSET
V
RT
AI
TGA
N
VNSAK
G
S
L
--
-
-
--DGPSRAVT
L
S
A
NDQ
M
Q
S
A
EE
Y
RQ
L
I
I
AYQ-
N
G
AP
I
R
L
G
DVA
T
VE
Q
G
A
E
NSWLG
A
WA
N
K
E
-
Q
A
I
V
MN
V
Q
R
QP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TES
L
P
K
S
VK
VTVL
S
D
R
T
TN
I
RA
S
V
D
D
TQFE
L
M
M
AI
A
LV
V
M
I
I
YLFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
A
V
M
V
F
L
D
F
S
I
N
N
LT
L
M
A
L
T
I
A
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
K
GEK
P
LA
A
AL
K
GAG
E
I
G
F
TI
ISLTFS
L
I
AV
L
IP
L
L
F
MG
D
IV
G
R
LF
R
E
F
A
IT
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRAS
E
KM
F
DRIIAA
----
Y
GQGLA
KVL
NHPWLT
L
S
V
A
L
S
TLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VA
D
--
VILQDPA
V
Q
S
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LE
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQ
V
SR
T
QYQFT
L
QAT---SL
D
A
L
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
QD
KGLVAY
VNVD
RD
S
A
S
R
L
G
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
L
E
HNTEN
T
PG
L
AA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KVEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SF
N
V
PDNY
S
L
G
D
A
VQAIMDTEKT
L
N
L
P
V
D
ITTQ
F
Q
G
ST
LA
F
Q
SA
L
GS--TVW
L
I
V
-
A
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAE
R
EQ
----------
G
MSPR
D
A
IYQ
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
IV
S
Q
V
L
T
L
F
TT
P
VI
Y
L
L
fig|316401.4.peg.2539
Escherichia coli ETEC H10407 (17-1021/1040)
I
M
RPVA
TTL
L
----
M
V
A
I
L
L
A
G
IIG
Y
RA
LPV
S
AL
P
E
V
DY
P
T
I
Q
V
V
T
L
YPGA
S
PD
V
M
T
S
A
VT
A
PL
E
RQ
F
GQ
M
S
GL
K
Q
MSS
Q
S
SG-
G
ASV
ITL
Q
F
Q
L
TL
P
L
D
V
A
EQ
E
VQ
AA
IN
A
A
TNL
LP
SDLPNP
P
V
YSKVNPADP
---
P
I
MTL
A
VT
S
T--AMPMT
Q
V
E
D
M
V
ETR
V
AQK
I
S
QIS
GVG
L
V
TLS
G
GQRPAV
R
V
K
L
NA
QA
IA
ALG
L
TSET
V
RT
AI
TGA
N
VNSAK
G
S
L
--
-
-
--DGPSRAVT
L
S
A
NDQ
M
Q
S
A
EE
Y
RQ
L
I
I
AYQ-
N
G
AP
I
R
L
G
DVA
T
VE
Q
G
A
E
NSWLG
A
WA
N
K
E
-
Q
A
I
V
MN
V
Q
R
QP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TES
L
P
K
S
VK
VTVL
S
D
R
T
TN
I
RA
S
V
N
D
TQFE
L
M
M
AI
A
LV
V
M
I
I
YLFL
R
N
I
P
AT
I
IP
G
F
AVP
L
S
L
I
GTF
A
V
M
V
F
L
D
F
S
I
N
N
LT
L
M
A
L
T
I
A
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
K
GEK
P
LA
A
AL
K
GAG
E
I
G
F
TI
ISLTFS
L
I
AV
L
IP
L
L
F
MG
D
IV
G
R
LF
R
E
F
A
IT
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRAS
E
KM
F
DRIIAA
----
Y
GRGLA
KVL
NHPWLT
L
S
V
A
L
S
TLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VA
D
--
VILQDPA
V
Q
S
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQ
V
SR
T
QYQFT
L
QAT---SL
D
A
L
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
QD
KGLVAY
VNVD
RD
S
A
S
R
L
G
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
L
E
HNTEN
T
PG
L
AA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SF
N
V
PDNY
S
L
G
D
A
VQAIMDTEKT
L
N
L
P
V
D
ITTQ
F
Q
G
S
P
LA
F
Q
SA
L
GS--TVW
L
I
V
-
A
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAE
R
EQ
----------
G
MSPR
EA
IYQ
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
IV
S
Q
V
L
T
L
F
TT
P
VI
Y
L
L
fig|701177.3.peg.2620
Escherichia coli O55:H7 str. CB9615 (17-1021/1040)
I
M
RPVA
TTL
L
----
M
V
A
I
L
L
A
G
IIG
Y
RA
LPV
S
AL
P
E
V
DY
P
T
I
Q
V
V
T
L
YPGA
S
PD
V
M
T
S
A
VT
A
PL
E
RQ
F
GQ
M
S
GL
K
Q
MSS
Q
S
SG-
G
ASV
ITL
Q
F
Q
L
TL
P
L
D
V
A
EQ
E
VQ
AA
IN
A
A
TNL
LP
SDLPNP
P
V
YSKVNPADP
---
P
I
MTL
T
VT
S
T--AMPMT
Q
V
E
D
M
V
ETR
V
AQK
I
S
QIS
GVG
L
V
TLS
G
GQRPAV
R
V
K
L
NA
QA
IA
ALG
L
TSET
V
RT
AI
TGA
N
VNSAK
G
S
L
--
-
-
--DGPSRAVT
L
S
A
NDQ
M
Q
S
A
EE
Y
RQ
L
I
I
AYQ-
N
G
AP
I
R
L
G
DVA
T
VE
Q
G
A
E
NSWLG
A
WA
N
K
E
-
Q
A
I
V
MN
V
Q
R
QP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TES
L
P
K
S
VK
VTVL
S
D
R
T
TN
I
RA
S
V
D
D
TQFE
L
M
M
AI
A
LV
V
M
I
I
YLFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
A
V
M
V
F
L
D
F
S
I
N
N
LT
L
M
A
L
T
I
A
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
K
GEK
P
LA
A
AL
K
GAG
E
I
G
F
TI
ISLTFS
L
I
AV
L
IP
L
L
F
MG
D
IV
G
R
LF
R
E
F
A
IT
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRAS
E
KM
F
DRIIAA
----
Y
GRGLA
KVL
NHPWLT
L
S
V
A
L
S
TLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VA
D
--
VILQDPA
V
Q
S
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQ
V
SR
T
QYQFT
L
QAT---SL
D
A
L
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
QD
KGLVAY
VNVD
RD
S
A
S
R
L
G
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
L
E
HNTEN
T
PG
L
AA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KVEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SF
N
V
PDNY
S
L
G
D
A
VQAIMDTEKT
L
N
L
P
V
D
ITTQ
F
Q
G
ST
LA
F
L
SA
L
GS--TVW
L
I
V
-
A
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAE
R
EQ
----------
G
MSPR
D
A
IYQ
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
IV
S
Q
V
L
T
L
F
TT
P
VI
Y
L
L
fig|344601.3.peg.3239
Escherichia coli B171 (8-1014/1025)
I
Y
R
R
VA
TIL
L
----
SV
A
I
T
L
C
G
ILG
F
RM
LPV
A
P
L
P
Q
V
DF
P
V
I
M
V
S
A
S
L
PGA
S
P
E
T
M
A
S
S
V
A
T
PL
E
RS
L
GR
I
A
G
V
S
E
M
T
S
S
S
SL-
G
STR
I
I
L
Q
F
D
F
DR
D
I
N
G
A
AR
D
VQ
AA
IN
A
A
QSL
LP
SGMPSR
P
T
YRKANPSDA
---
P
I
MIL
T
LT
S
D--TYSQG
EL
Y
D
F
A
STQ
L
APT
I
S
QID
GVG
D
V
DVG
G
SSLPAV
R
V
G
L
N
P
QA
L
F
NQG
V
SLDD
V
RT
AI
SNA
N
VRKPQ
G
A
L
--
-
-
--EDGTHRWQ
I
Q
T
NDE
L
K
T
A
D
E
Y
QP
L
I
I
HYN-
N
G
GA
V
R
L
G
DVA
T
V
T
D
S
V
Q
DVRNA
G
MT
N
A
K
-
P
A
I
L
LM
I
R
K
LP
E
AN
IIQ
T
VDS
I
RAK
L
PE
L
QET
I
P
A
A
I
D
LQIA
Q
D
RS
PT
I
RS
S
L
E
E
VEQT
L
I
I
SV
A
LV
I
LV
V
F
LFL
R
S
G
RAT
I
IP
A
VS
VPV
S
L
I
GTF
A
A
M
Y
L
C
G
F
S
L
N
N
L
SL
M
A
L
T
I
A
T
G
F
V
VDDAIVV
L
EN
IA
R
H
L
-
E
----------
A
GMK
P
LQ
A
AL
Q
GTR
EVG
F
T
V
LSMSLS
L
V
AVF
L
P
L
L
L
MG
G
LP
G
R
L
L
R
E
F
A
V
T
LSV
A
I
GI
S
L
L
V
S
L
T
LTP
M
M
C
G
WM
L
KASKPRE---QKRM----
-
RG
F
GRMLVA
LQQG
Y
GKSLK
W
VL
NHTRLV
G
V
V
L
L
G
TIALNIW
L
YISI
P
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
A
D
Q
S
I
S
FQAMRGKLQ
D
FM
K
--
IIRDDPA
V
D
N
V
T
GFT
G
----GSRV
N
SGMMF
---
I
T
LKP
RD
E
-
R
S---ETAQ
Q
II
D
R
L
RVKLAKEPGAN
L
FLM
A
V
-
QDIR
V
GGR
Q
SN
A
SYQYT
L
LSD---DL
A
A
L
REWEP
K
I
RKK
L
ATL
P
-E
L
AD
V
NS
D
Q
QD
NGAEMN
L
VY
D
RD
TM
A
R
L
G
I
D
V
Q
AA
NSL
L
N
N
A
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
ME
VDPRY
T
QD
I
SA
L
EKMF
V
I
N
NE
G
KAI
PLS
YF
A
KWQPAN
AP
LS
V
NHQ
G
LS
A
AST
I
SF
NL
PTGK
S
L
S
D
A
SAAIDRAMTQ
L
G
V
P
S
T
VRGS
F
A
G
TA
QV
F
Q
ET
M
NS--QVI
L
I
I
-
A
A
I
A
T
V
Y
I
V
L
GI
LYES
YVH
P
LT
I
L
S
T
L
P
S
A
G
VG
A
LLA
LELF
N
AP
F
S
L
IALI
G
I
M
LL
IG
I
V
K
KNAI
M
M
V
D
FA
LEAQ
R
HG
----------
N
LTPQ
EA
IFQ
A
CLL
R
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GS
E
LRQP
L
G
I
T
IV
GG
L
VM
S
Q
LL
T
LY
TT
P
VV
Y
L
FFDRL
R
L
R
fig|344601.5.peg.3385
Escherichia coli B171 (8-1014/1025)
I
Y
R
R
VA
TIL
L
----
SV
A
I
T
L
C
G
ILG
F
RM
LPV
A
P
L
P
Q
V
DF
P
V
I
M
V
S
A
S
L
PGA
S
P
E
T
M
A
S
S
V
A
T
PL
E
RS
L
GR
I
A
G
V
S
E
M
T
S
S
S
SL-
G
STR
I
I
L
Q
F
D
F
DR
D
I
N
G
A
AR
D
VQ
AA
IN
A
A
QSL
LP
SGMPSR
P
T
YRKANPSDA
---
P
I
MIL
T
LT
S
D--TYSQG
EL
Y
D
F
A
STQ
L
APT
I
S
QID
GVG
D
V
DVG
G
SSLPAV
R
V
G
L
N
P
QA
L
F
NQG
V
SLDD
V
RT
AI
SNA
N
VRKPQ
G
A
L
--
-
-
--EDGTHRWQ
I
Q
T
NDE
L
K
T
A
D
E
Y
QP
L
I
I
HYN-
N
G
GA
V
R
L
G
DVA
T
V
T
D
S
V
Q
DVRNA
G
MT
N
A
K
-
P
A
I
L
LM
I
R
K
LP
E
AN
IIQ
T
VDS
I
RAK
L
PE
L
QET
I
P
A
A
I
D
LQIA
Q
D
RS
PT
I
RS
S
L
E
E
VEQT
L
I
I
SV
A
LV
I
LV
V
F
LFL
R
S
G
RAT
I
IP
A
VS
VPV
S
L
I
GTF
A
A
M
Y
L
C
G
F
S
L
N
N
L
SL
M
A
L
T
I
A
T
G
F
V
VDDAIVV
L
EN
IA
R
H
L
-
E
----------
A
GMK
P
LQ
A
AL
Q
GTR
EVG
F
T
V
LSMSLS
L
V
AVF
L
P
L
L
L
MG
G
LP
G
R
L
L
R
E
F
A
V
T
LSV
A
I
GI
S
L
L
V
S
L
T
LTP
M
M
C
G
WM
L
KASKPRE---QKRM----
-
RG
F
GRMLVA
LQQG
Y
GKSLK
W
VL
NHTRLV
G
V
V
L
L
G
TIALNIW
L
YISI
P
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
A
D
Q
S
I
S
FQAMRGKLQ
D
FM
K
--
IIRDDPA
V
D
N
V
T
GFT
G
----GSRV
N
SGMMF
---
I
T
LKP
RD
E
-
R
S---ETAQ
Q
II
D
R
L
RVKLAKEPGAN
L
FLM
A
V
-
QDIR
V
GGR
Q
SN
A
SYQYT
L
LSD---DL
A
A
L
REWEP
K
I
RKK
L
ATL
P
-E
L
AD
V
NS
D
Q
QD
NGAEMN
L
VY
D
RD
TM
A
R
L
G
I
D
V
Q
AA
NSL
L
N
N
A
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
ME
VDPRY
T
QD
I
SA
L
EKMF
V
I
N
NE
G
KAI
PLS
YF
A
KWQPAN
AP
LS
V
NHQ
G
LS
A
AST
I
SF
NL
PTGK
S
L
S
D
A
SAAIDRAMTQ
L
G
V
P
S
T
VRGS
F
A
G
TA
QV
F
Q
ET
M
NS--QVI
L
I
I
-
A
A
I
A
T
V
Y
I
V
L
GI
LYES
YVH
P
LT
I
L
S
T
L
P
S
A
G
VG
A
LLA
LELF
N
AP
F
S
L
IALI
G
I
M
LL
IG
I
V
K
KNAI
M
M
V
D
FA
LEAQ
R
HG
----------
N
LTPQ
EA
IFQ
A
CLL
R
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GS
E
LRQP
L
G
I
T
IV
GG
L
VM
S
Q
LL
T
LY
TT
P
VV
Y
L
FFDRL
R
L
R
fig|701177.3.peg.4003
Escherichia coli O55:H7 str. CB9615 (1-1018/1034)
M
ANFF
IRRP
IF
AWV
L
----
AI
I
L
M
M
A
G
ALA
I
LQ
LPV
A
QYP
T
I
AP
P
A
V
S
V
S
A
N
YPGA
D
AQ
T
V
Q
D
T
VT
Q
VIE
QN
M
NG
I
D
N
LM
Y
MSS
T
S
DSA
G
SVT
ITL
T
F
Q
S
GT
D
PD
I
A
QV
QVQ
NK
LQ
L
A
TPL
LP
QEVQQQ
G
I
SVE-KSSSS
---
Y
L
MVA
G
FV
S
DNPDTTQD
DI
S
D
Y
V
ASN
V
KDT
LS
RLN
S
VG
D
V
QLF
G
AQY-AM
RI
W
LD
A
DL
LN
KYK
L
TPVD
V
IN
QL
KVQ
N
DQIAA
GQLGG
T
P
ALPGQQLNAS
I
I
A
QTR
L
K
N
P
EEF
GK
V
T
L
RVNS
DG
SV
V
R
L
K
DVA
R
VE
L
G
G
E
NYNVI
A
RI
NGK
-
P
A
A
G
LG
I
K
L
AT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPF
FP
Q
G
M
K
VLYP
YDTT
PF
V
QL
SI
H
E
VVKT
L
F
EAI
M
LV
F
LV
M
YLFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
A
I
L
A
A
F
G
Y
S
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
D
KLP
P
KE
A
TE
K
SMS
QIQ
G
AL
VGIAMV
L
S
AVFIPM
A
F
FG
G
ST
G
A
IYR
Q
FSIT
IVS
AM
AL
SV
L
VAL
I
LTP
A
LCA
TL
L
KPTSAEHHENKGGFFGWF
N
TT
F
DHSVNH
----
Y
TNSVG
K
I
L
GSTGRY
L
L
I
Y
A
L
IVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VT
DYY
LKNEKAN
V
E
SVF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
NGDENSAE
A
V
I
H
RA
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VEL
G
TA
T
GFDFE
L
IDKAGLGH
D
A
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
L
E
VD
QE
KA
Q
A
L
GVSL
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
ML
P
ED
V
DKLY
V
R
S
TN
G
EMV
P
F
S
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QG
EA
APGT
S
S
G
D
A
MALMENLASK
L
-
-
P
A
G
IGYD
W
T
G
--
MS
YQ
ER
L
SGNQAPA
L
V
A
-
I
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLM
E
KE
----------
G
KGVV
EA
TLM
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
VS
A
T
LLAI
fig|585397.7.peg.4182
Escherichia coli ED1a (16-1018/1037)
AI
I
M
M
L
A
G
GLA
I
MN
LPV
A
QYP
Q
I
AP
P
T
I
T
I
S
A
T
YPGA
D
AQ
T
V
E
D
S
VT
Q
VIE
QN
M
NG
L
D
GLM
Y
MSS
T
S
DAA
G
NAS
ITL
T
FE
T
GT
S
PD
I
A
QV
QVQ
NK
LQ
L
A
MPS
LP
EAVQQQ
G
I
SVD-KSSSN
---
I
L
MVA
A
FI
S
DNGSLNQY
DI
A
D
Y
V
ASN
I
KDP
LS
RTA
GVG
S
V
QLF
G
SEY-AM
RI
W
LDP
QK
LN
KYN
L
VPSD
V
IS
Q
I
KVQ
N
NQISG
GQLGG
M
P
QAADQQLNAS
I
I
V
QTR
LQT
P
EEF
GK
I
L
L
KVQQ
DG
SQ
V
L
L
R
DVA
R
VE
L
G
A
E
DYSTV
A
RY
NGK
-
P
A
A
G
IA
I
K
L
AT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAY
FP
A
S
L
K
TVYP
YDTT
PF
I
KI
SI
Q
E
VFKT
L
V
EAI
I
LV
F
LV
M
YLFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
A
I
L
S
A
V
G
F
T
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
D
KLP
P
KE
A
TH
K
SMG
QIQ
R
AL
VGIAVV
L
S
AVF
M
PM
A
F
MS
G
AT
G
E
IYR
Q
FSIT
LIS
S
M
LL
SV
F
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNTLFARF
N
TL
F
EKSTQH
----
Y
TDSTR
S
L
L
RCTGRY
M
V
VY
L
L
ICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
L
P
S
G
A
T
MVNTTKVLQ
Q
VT
DYY
LTKEKNN
V
Q
SVF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVT
AII
Q
RA
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AEL
G
TA
S
GFDME
L
LDNGNLGH
E
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
IG
V
RP
N
G
LE
DTPMFK
VNV
N
AA
KA
E
A
M
GV
A
L
S
DI
NQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
ML
P
DN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
GS
PR
L
ERY
N
GI
P
SME
I
LG
EA
AAGK
S
T
G
D
A
MKFMADLVAK
L
-
-
P
A
G
VGYS
W
T
G
--
LS
YQ
EA
L
SSNQAPA
L
Y
A
-
I
S
L
V
V
VFL
A
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LS
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
VEMM
Q
KE
----------
G
KTPV
EA
IIE
A
ARM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
VI
S
H
GAGSG
AQNA
A
G
T
GVMGGM
FA
A
T
V
LAI
Y
fig|585397.9.peg.4179
Escherichia coli ED1a (16-1018/1037)
AI
I
M
M
L
A
G
GLA
I
MN
LPV
A
QYP
Q
I
AP
P
T
I
T
I
S
A
T
YPGA
D
AQ
T
V
E
D
S
VT
Q
VIE
QN
M
NG
L
D
GLM
Y
MSS
T
S
DAA
G
NAS
ITL
T
FE
T
GT
S
PD
I
A
QV
QVQ
NK
LQ
L
A
MPS
LP
EAVQQQ
G
I
SVD-KSSSN
---
I
L
MVA
A
FI
S
DNGSLNQY
DI
A
D
Y
V
ASN
I
KDP
LS
RTA
GVG
S
V
QLF
G
SEY-AM
RI
W
LDP
QK
LN
KYN
L
VPSD
V
IS
Q
I
KVQ
N
NQISG
GQLGG
M
P
QAADQQLNAS
I
I
V
QTR
LQT
P
EEF
GK
I
L
L
KVQQ
DG
SQ
V
L
L
R
DVA
R
VE
L
G
A
E
DYSTV
A
RY
NGK
-
P
A
A
G
IA
I
K
L
AT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAY
FP
A
S
L
K
TVYP
YDTT
PF
I
KI
SI
Q
E
VFKT
L
V
EAI
I
LV
F
LV
M
YLFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
A
I
L
S
A
V
G
F
T
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
D
KLP
P
KE
A
TH
K
SMG
QIQ
R
AL
VGIAVV
L
S
AVF
M
PM
A
F
MS
G
AT
G
E
IYR
Q
FSIT
LIS
S
M
LL
SV
F
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNTLFARF
N
TL
F
EKSTQH
----
Y
TDSTR
S
L
L
RCTGRY
M
V
VY
L
L
ICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
L
P
S
G
A
T
MVNTTKVLQ
Q
VT
DYY
LTKEKNN
V
Q
SVF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVT
AII
Q
RA
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AEL
G
TA
S
GFDME
L
LDNGNLGH
E
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
IG
V
RP
N
G
LE
DTPMFK
VNV
N
AA
KA
E
A
M
GV
A
L
S
DI
NQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
ML
P
DN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
GS
PR
L
ERY
N
GI
P
SME
I
LG
EA
AAGK
S
T
G
D
A
MKFMADLVAK
L
-
-
P
A
G
VGYS
W
T
G
--
LS
YQ
EA
L
SSNQAPA
L
Y
A
-
I
S
L
V
V
VFL
A
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LS
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
VEMM
Q
KE
----------
G
KTPV
EA
IIE
A
ARM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
VI
S
H
GAGSG
AQNA
A
G
T
GVMGGM
FA
A
T
V
LAI
Y
fig|358709.5.peg.523
Escherichia coli 101-1 (17-1021/1040)
I
M
RPVA
TTL
L
----
M
V
A
I
L
L
A
G
IIG
Y
RA
LPV
S
AL
P
E
V
DY
P
T
I
Q
V
V
T
L
YPGA
S
PD
V
M
T
S
A
VT
A
PL
E
RQ
F
GQ
M
S
GL
K
Q
MSS
Q
S
SG-
G
ASV
ITL
Q
F
Q
L
TL
P
L
D
V
A
EQ
E
VQ
AA
IN
A
A
TNL
LP
SDLPNP
P
V
YSKVNPADP
---
P
I
MTL
A
VT
S
T--AMPMT
Q
V
E
D
M
V
ETR
V
AQK
I
S
QIS
GVG
L
V
TLS
G
GQRPAV
R
V
K
L
NA
QA
IA
ALG
L
TSET
V
RT
AI
TGA
N
VNSAK
G
S
L
--
-
-
--DGPSRAVT
L
S
A
NDQ
M
Q
S
A
EE
Y
RQ
L
I
I
AYQ-
N
G
AP
I
R
L
G
DVA
T
VE
Q
G
A
E
NSWLG
A
WA
N
K
E
-
Q
A
I
V
MN
V
Q
R
QP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TES
L
P
K
S
VK
VTVL
S
D
R
T
TN
I
RA
S
V
N
D
TQFE
L
M
M
AI
A
LV
V
M
I
I
YLFL
R
N
I
P
AT
I
IP
G
F
AVP
L
S
L
I
GTF
A
V
M
V
F
L
D
F
S
I
N
N
LT
L
M
A
L
T
I
A
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
K
GEK
P
LA
A
AL
K
GAG
E
I
G
F
TI
ISLTFS
L
I
AV
L
IP
L
L
F
MG
D
IV
G
R
LF
R
E
F
A
IT
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRAS
E
KM
F
DRIIAA
----
Y
GRGLA
KVL
NHPWLT
L
S
V
A
L
S
TLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VA
D
--
VILQDPA
V
Q
S
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQ
V
SR
T
QYQFT
L
QAT---SL
D
A
L
STWVP
E
L
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
QD
KGLVAY
VNVD
RD
S
A
S
R
L
G
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
L
E
HNTEN
T
PG
L
AA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SF
N
V
PDNY
S
L
G
D
A
VQAIMDTEKT
L
N
L
P
V
D
ITTQ
F
Q
G
ST
LA
F
Q
SA
L
GS--TVW
L
I
V
-
A
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAE
R
EQ
----------
G
MSPR
EA
IYQ
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
IV
S
Q
V
L
T
L
F
TT
P
VI
Y
L
L
fig|413997.3.peg.2072
Escherichia coli B str. REL606 (17-1021/1040)
I
M
RPVA
TTL
L
----
M
V
A
I
L
L
A
G
IIG
Y
RA
LPV
S
AL
P
E
V
DY
P
T
I
Q
V
V
T
L
YPGA
S
PD
V
M
T
S
A
VT
A
PL
E
RQ
F
GQ
M
S
GL
K
Q
MSS
Q
S
SG-
G
ASV
ITL
Q
F
Q
L
TL
P
L
D
V
A
EQ
E
VQ
AA
IN
A
A
TNL
LP
SDLPNP
P
V
YSKVNPADP
---
P
I
MTL
A
VT
S
T--AMPMT
Q
V
E
D
M
V
ETR
V
AQK
I
S
QIS
GVG
L
V
TLS
G
GQRPAV
R
V
K
L
NA
QA
IA
ALG
L
TSET
V
RT
AI
TGA
N
VNSAK
G
S
L
--
-
-
--DGPSRAVT
L
S
A
NDQ
M
Q
S
A
EE
Y
RQ
L
I
I
AYQ-
N
G
AP
I
R
L
G
DVA
T
VE
Q
G
A
E
NSWLG
A
WA
N
K
E
-
Q
A
I
V
MN
V
Q
R
QP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TES
L
P
K
S
VK
VTVL
S
D
R
T
TN
I
RA
S
V
N
D
TQFE
L
M
M
AI
A
LV
V
M
I
I
YLFL
R
N
I
P
AT
I
IP
G
F
AVP
L
S
L
I
GTF
A
V
M
V
F
L
D
F
S
I
N
N
LT
L
M
A
L
T
I
A
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
K
GEK
P
LA
A
AL
K
GAG
E
I
G
F
TI
ISLTFS
L
I
AV
L
IP
L
L
F
MG
D
IV
G
R
LF
R
E
F
A
IT
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRAS
E
KM
F
DRIIAA
----
Y
GRGLA
KVL
NHPWLT
L
S
V
A
L
S
TLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VA
D
--
VILQDPA
V
Q
S
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQ
V
SR
T
QYQFT
L
QAT---SL
D
A
L
STWVP
E
L
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
QD
KGLVAY
VNVD
RD
S
A
S
R
L
G
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
L
E
HNTEN
T
PG
L
AA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SF
N
V
PDNY
S
L
G
D
A
VQAIMDTEKT
L
N
L
P
V
D
ITTQ
F
Q
G
ST
LA
F
Q
SA
L
GS--TVW
L
I
V
-
A
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAE
R
EQ
----------
G
MSPR
EA
IYQ
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
IV
S
Q
V
L
T
L
F
TT
P
VI
Y
L
L
fig|511693.5.peg.2103
Escherichia coli BL21 (17-1021/1040)
I
M
RPVA
TTL
L
----
M
V
A
I
L
L
A
G
IIG
Y
RA
LPV
S
AL
P
E
V
DY
P
T
I
Q
V
V
T
L
YPGA
S
PD
V
M
T
S
A
VT
A
PL
E
RQ
F
GQ
M
S
GL
K
Q
MSS
Q
S
SG-
G
ASV
ITL
Q
F
Q
L
TL
P
L
D
V
A
EQ
E
VQ
AA
IN
A
A
TNL
LP
SDLPNP
P
V
YSKVNPADP
---
P
I
MTL
A
VT
S
T--AMPMT
Q
V
E
D
M
V
ETR
V
AQK
I
S
QIS
GVG
L
V
TLS
G
GQRPAV
R
V
K
L
NA
QA
IA
ALG
L
TSET
V
RT
AI
TGA
N
VNSAK
G
S
L
--
-
-
--DGPSRAVT
L
S
A
NDQ
M
Q
S
A
EE
Y
RQ
L
I
I
AYQ-
N
G
AP
I
R
L
G
DVA
T
VE
Q
G
A
E
NSWLG
A
WA
N
K
E
-
Q
A
I
V
MN
V
Q
R
QP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TES
L
P
K
S
VK
VTVL
S
D
R
T
TN
I
RA
S
V
N
D
TQFE
L
M
M
AI
A
LV
V
M
I
I
YLFL
R
N
I
P
AT
I
IP
G
F
AVP
L
S
L
I
GTF
A
V
M
V
F
L
D
F
S
I
N
N
LT
L
M
A
L
T
I
A
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
K
GEK
P
LA
A
AL
K
GAG
E
I
G
F
TI
ISLTFS
L
I
AV
L
IP
L
L
F
MG
D
IV
G
R
LF
R
E
F
A
IT
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRAS
E
KM
F
DRIIAA
----
Y
GRGLA
KVL
NHPWLT
L
S
V
A
L
S
TLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VA
D
--
VILQDPA
V
Q
S
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQ
V
SR
T
QYQFT
L
QAT---SL
D
A
L
STWVP
E
L
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
QD
KGLVAY
VNVD
RD
S
A
S
R
L
G
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
L
E
HNTEN
T
PG
L
AA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SF
N
V
PDNY
S
L
G
D
A
VQAIMDTEKT
L
N
L
P
V
D
ITTQ
F
Q
G
ST
LA
F
Q
SA
L
GS--TVW
L
I
V
-
A
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAE
R
EQ
----------
G
MSPR
EA
IYQ
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
IV
S
Q
V
L
T
L
F
TT
P
VI
Y
L
L
fig|469008.4.peg.1629
Escherichia coli BL21(DE3) (17-1021/1040)
I
M
RPVA
TTL
L
----
M
V
A
I
L
L
A
G
IIG
Y
RA
LPV
S
AL
P
E
V
DY
P
T
I
Q
V
V
T
L
YPGA
S
PD
V
M
T
S
A
VT
A
PL
E
RQ
F
GQ
M
S
GL
K
Q
MSS
Q
S
SG-
G
ASV
ITL
Q
F
Q
L
TL
P
L
D
V
A
EQ
E
VQ
AA
IN
A
A
TNL
LP
SDLPNP
P
V
YSKVNPADP
---
P
I
MTL
A
VT
S
T--AMPMT
Q
V
E
D
M
V
ETR
V
AQK
I
S
QIS
GVG
L
V
TLS
G
GQRPAV
R
V
K
L
NA
QA
IA
ALG
L
TSET
V
RT
AI
TGA
N
VNSAK
G
S
L
--
-
-
--DGPSRAVT
L
S
A
NDQ
M
Q
S
A
EE
Y
RQ
L
I
I
AYQ-
N
G
AP
I
R
L
G
DVA
T
VE
Q
G
A
E
NSWLG
A
WA
N
K
E
-
Q
A
I
V
MN
V
Q
R
QP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TES
L
P
K
S
VK
VTVL
S
D
R
T
TN
I
RA
S
V
N
D
TQFE
L
M
M
AI
A
LV
V
M
I
I
YLFL
R
N
I
P
AT
I
IP
G
F
AVP
L
S
L
I
GTF
A
V
M
V
F
L
D
F
S
I
N
N
LT
L
M
A
L
T
I
A
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
K
GEK
P
LA
A
AL
K
GAG
E
I
G
F
TI
ISLTFS
L
I
AV
L
IP
L
L
F
MG
D
IV
G
R
LF
R
E
F
A
IT
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRAS
E
KM
F
DRIIAA
----
Y
GRGLA
KVL
NHPWLT
L
S
V
A
L
S
TLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VA
D
--
VILQDPA
V
Q
S
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQ
V
SR
T
QYQFT
L
QAT---SL
D
A
L
STWVP
E
L
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
QD
KGLVAY
VNVD
RD
S
A
S
R
L
G
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
L
E
HNTEN
T
PG
L
AA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SF
N
V
PDNY
S
L
G
D
A
VQAIMDTEKT
L
N
L
P
V
D
ITTQ
F
Q
G
ST
LA
F
Q
SA
L
GS--TVW
L
I
V
-
A
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAE
R
EQ
----------
G
MSPR
EA
IYQ
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
IV
S
Q
V
L
T
L
F
TT
P
VI
Y
L
L
fig|749547.3.peg.3117
Escherichia coli MS 187-1 (17-1021/1040)
I
M
RPVA
TTL
L
----
M
V
A
I
L
L
A
G
IIG
Y
RA
LPV
S
AL
P
E
V
DY
P
T
I
Q
V
V
T
L
YPGA
S
PD
V
M
T
S
A
VT
A
PL
E
RQ
F
GQ
M
S
GL
K
Q
MSS
Q
S
SG-
G
ASV
ITL
Q
F
Q
L
TL
P
L
D
V
A
EQ
E
VQ
AA
IN
A
A
TNL
LP
SDLPNP
P
V
YSKVNPADP
---
P
I
MTL
A
VT
S
T--AMPMT
Q
V
E
D
M
V
ETR
V
AQK
I
S
QIS
GVG
L
V
TLS
G
GQRPAV
R
V
K
L
NA
QA
IA
ALG
L
TSET
V
RT
AI
TGA
N
VNSAK
G
S
L
--
-
-
--DGPSRAVT
L
S
A
NDQ
M
Q
S
A
EE
Y
RQ
L
I
I
AYQ-
N
G
AP
I
R
L
G
DVA
T
VE
Q
G
A
E
NSWLG
A
WA
N
K
E
-
Q
A
I
V
MN
V
Q
R
QP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TES
L
P
K
S
VK
VTVL
S
D
R
T
TN
I
RA
S
V
N
D
TQFE
L
M
M
AI
A
LV
V
M
I
I
YLFL
R
N
I
P
AT
I
IP
G
F
AVP
L
S
L
I
GTF
A
V
M
V
F
L
D
F
S
I
N
N
LT
L
M
A
L
T
I
A
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
K
GEK
P
LA
A
AL
K
GAG
E
I
G
F
TI
ISLTFS
L
I
AV
L
IP
L
L
F
MG
D
IV
G
R
LF
R
E
F
A
IT
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRAS
E
KM
F
DRIIAA
----
Y
GRGLA
KVL
NHPWLT
L
S
V
A
L
S
TLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VA
D
--
VILQDPA
V
Q
S
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQ
V
SR
T
QYQFT
L
QAT---SL
D
A
L
STWVP
E
L
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
QD
KGLVAY
VNVD
RD
S
A
S
R
L
G
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
L
E
HNTEN
T
PG
L
AA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SF
N
V
PDNY
S
L
G
D
A
VQAIMDTEKT
L
N
L
P
V
D
ITTQ
F
Q
G
ST
LA
F
Q
SA
L
GS--TVW
L
I
V
-
A
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAE
R
EQ
----------
G
MSPR
EA
IYQ
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
IV
S
Q
V
L
T
L
F
TT
P
VI
Y
L
L
fig|749548.3.peg.2930
Escherichia coli MS 196-1 (17-1021/1040)
I
M
RPVA
TTL
L
----
M
V
A
I
L
L
A
G
IIG
Y
RA
LPV
S
AL
P
E
V
DY
P
T
I
Q
V
V
T
L
YPGA
S
PD
V
M
T
S
A
VT
A
PL
E
RQ
F
GQ
M
S
GL
K
Q
MSS
Q
S
SG-
G
ASV
ITL
Q
F
Q
L
TL
P
L
D
V
A
EQ
E
VQ
AA
IN
A
A
TNL
LP
SDLPNP
P
V
YSKVNPADP
---
P
I
MTL
A
VT
S
T--AMPMT
Q
V
E
D
M
V
ETR
V
AQK
I
S
QIS
GVG
L
V
TLS
G
GQRPAV
R
V
K
L
NA
QA
IA
ALG
L
TSET
V
RT
AI
TGA
N
VNSAK
G
S
L
--
-
-
--DGPSRAVT
L
S
A
NDQ
M
Q
S
A
EE
Y
RQ
L
I
I
AYQ-
N
G
AP
I
R
L
G
DVA
T
VE
Q
G
A
E
NSWLG
A
WA
N
K
E
-
Q
A
I
V
MN
V
Q
R
QP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TES
L
P
K
S
VK
VTVL
S
D
R
T
TN
I
RA
S
V
N
D
TQFE
L
M
M
AI
A
LV
V
M
I
I
YLFL
R
N
I
P
AT
I
IP
G
F
AVP
L
S
L
I
GTF
A
V
M
V
F
L
D
F
S
I
N
N
LT
L
M
A
L
T
I
A
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
K
GEK
P
LA
A
AL
K
GAG
E
I
G
F
TI
ISLTFS
L
I
AV
L
IP
L
L
F
MG
D
IV
G
R
LF
R
E
F
A
IT
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRAS
E
KM
F
DRIIAA
----
Y
GRGLA
KVL
NHPWLT
L
S
V
A
L
S
TLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VA
D
--
VILQDPA
V
Q
S
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQ
V
SR
T
QYQFT
L
QAT---SL
D
A
L
STWVP
E
L
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
QD
KGLVAY
VNVD
RD
S
A
S
R
L
G
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
L
E
HNTEN
T
PG
L
AA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SF
N
V
PDNY
S
L
G
D
A
VQAIMDTEKT
L
N
L
P
V
D
ITTQ
F
Q
G
ST
LA
F
Q
SA
L
GS--TVW
L
I
V
-
A
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAE
R
EQ
----------
G
MSPR
EA
IYQ
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
IV
S
Q
V
L
T
L
F
TT
P
VI
Y
L
L
fig|749549.3.peg.1282
Escherichia coli MS 198-1 (17-1021/1040)
I
M
RPVA
TTL
L
----
M
V
A
I
L
L
A
G
IIG
Y
RA
LPV
S
AL
P
E
V
DY
P
T
I
Q
V
V
T
L
YPGA
S
PD
V
M
T
S
A
VT
A
PL
E
RQ
F
GQ
M
S
GL
K
Q
MSS
Q
S
SG-
G
ASV
ITL
Q
F
Q
L
TL
P
L
D
V
A
EQ
E
VQ
AA
IN
A
A
TNL
LP
SDLPNP
P
V
YSKVNPADP
---
P
I
MTL
A
VT
S
T--AMPMT
Q
V
E
D
M
V
ETR
V
AQK
I
S
QIS
GVG
L
V
TLS
G
GQRPAV
R
V
K
L
NA
QA
IA
ALG
L
TSET
V
RT
AI
TGA
N
VNSAK
G
S
L
--
-
-
--DGPSRAVT
L
S
A
NDQ
M
Q
S
A
EE
Y
RQ
L
I
I
AYQ-
N
G
AP
I
R
L
G
DVA
T
VE
Q
G
A
E
NSWLG
A
WA
N
K
E
-
Q
A
I
V
MN
V
Q
R
QP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TES
L
P
K
S
VK
VTVL
S
D
R
T
TN
I
RA
S
V
N
D
TQFE
L
M
M
AI
A
LV
V
M
I
I
YLFL
R
N
I
P
AT
I
IP
G
F
AVP
L
S
L
I
GTF
A
V
M
V
F
L
D
F
S
I
N
N
LT
L
M
A
L
T
I
A
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
K
GEK
P
LA
A
AL
K
GAG
E
I
G
F
TI
ISLTFS
L
I
AV
L
IP
L
L
F
MG
D
IV
G
R
LF
R
E
F
A
IT
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRAS
E
KM
F
DRIIAA
----
Y
GRGLA
KVL
NHPWLT
L
S
V
A
L
S
TLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VA
D
--
VILQDPA
V
Q
S
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQ
V
SR
T
QYQFT
L
QAT---SL
D
A
L
STWVP
E
L
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
QD
KGLVAY
VNVD
RD
S
A
S
R
L
G
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
L
E
HNTEN
T
PG
L
AA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SF
N
V
PDNY
S
L
G
D
A
VQAIMDTEKT
L
N
L
P
V
D
ITTQ
F
Q
G
ST
LA
F
Q
SA
L
GS--TVW
L
I
V
-
A
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAE
R
EQ
----------
G
MSPR
EA
IYQ
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
IV
S
Q
V
L
T
L
F
TT
P
VI
Y
L
L
fig|670897.3.peg.4068
Escherichia coli 2362-75 (1-1018/1034)
M
ANFF
IRRP
IF
AWV
L
----
AI
I
L
M
M
A
G
ALA
I
LQ
LPV
A
QYP
T
I
AP
P
A
V
S
V
S
A
N
YPGA
D
AQ
T
V
Q
D
T
VT
Q
VIE
QN
M
NG
I
D
N
LM
Y
MSS
T
S
DSA
G
SVT
ITL
T
F
Q
S
GT
D
PD
I
A
QV
QVQ
NK
LQ
L
A
TPL
LP
QEVQQQ
G
I
SVE-KSSSS
---
Y
L
MVA
G
FV
S
DNPGTTQD
DI
S
D
Y
V
ASN
V
KDT
LS
RLN
GVG
D
V
QLF
G
AQY-AM
RI
W
LD
A
DL
LN
KYK
L
TPVD
V
IN
QL
KVQ
N
DQIAA
GQLGG
T
P
ALPGQQLNAS
I
I
A
QTR
L
K
N
P
EEF
GK
V
T
L
RVNS
DG
SV
V
R
L
K
DVA
R
VE
L
G
G
E
NYNVI
A
RI
NGK
-
P
A
A
G
LG
I
K
L
AT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPF
FP
Q
G
M
K
VLYP
YDTT
PF
V
QL
SI
Q
E
VVKT
L
F
EAI
I
LV
F
LV
M
YLFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
A
I
L
A
A
F
G
Y
S
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
D
KLP
P
KE
A
TE
K
SMS
QIQ
G
AL
VGIAMV
L
S
AVFIPM
A
F
FG
G
ST
G
A
IYR
Q
FSIT
IVS
AM
AL
SV
L
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWF
N
TT
F
DHSVNH
----
Y
TNSVG
K
I
L
GSTGRY
L
L
I
Y
A
L
IVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VT
DYY
LKNEKAN
V
E
SVF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
SGDENSAE
A
V
I
H
RA
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VEL
G
TA
T
GFDFE
L
IDQAGLGH
D
A
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
L
E
VD
QE
KA
Q
A
L
GVSL
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
ML
P
ED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QG
EA
APGT
S
S
G
D
A
MALMENLASK
L
-
-
P
A
G
IGYD
W
T
G
--
MS
YQ
ER
L
SGNQAPA
L
V
A
-
I
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLM
E
KE
----------
G
KGVV
EA
TLM
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
VS
A
T
LLAI
fig|562.376.peg.1659
Escherichia coli WV_060327 (1-1018/1034)
M
ANFF
IRRP
IF
AWV
L
----
AI
I
L
M
M
A
G
ALA
I
LQ
LPV
A
QYP
T
I
AP
P
A
V
S
V
S
A
N
YPGA
D
AQ
T
V
Q
D
T
VT
Q
VIE
QN
M
NG
I
D
N
LM
Y
MSS
T
S
DSA
G
SVT
ITL
T
F
Q
S
GT
D
PD
I
A
QV
QVQ
NK
LQ
L
A
TPL
LP
QEVQQQ
G
I
SVE-KSSSS
---
Y
L
MVA
G
FV
S
DNPGTTQD
DI
S
D
Y
V
ASN
V
KDT
LS
RLN
GVG
D
V
QLF
G
AQY-AM
RI
W
LD
A
DL
LN
KYK
L
TPVD
V
IN
QL
KVQ
N
DQIAA
GQLGG
T
P
ALPGQQLNAS
I
I
A
QTR
L
K
N
P
EEF
GK
V
T
L
RVNS
DG
SV
V
R
L
K
DVA
R
VE
L
G
G
E
NYNVI
A
RI
NGK
-
P
A
A
G
LG
I
K
L
AT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPF
FP
Q
G
M
K
VLYP
YDTT
PF
V
QL
SI
Q
E
VVKT
L
F
EAI
I
LV
F
LV
M
YLFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
A
I
L
A
A
F
G
Y
S
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
D
KLP
P
KE
A
TE
K
SMS
QIQ
G
AL
VGIAMV
L
S
AVFIPM
A
F
FG
G
ST
G
A
IYR
Q
FSIT
IVS
AM
AL
SV
L
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWF
N
TT
F
DHSVNH
----
Y
TNSVG
K
I
L
GSTGRY
L
L
I
Y
A
L
IVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VT
DYY
LKNEKAN
V
E
SVF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
SGDENSAE
A
V
I
H
RA
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VEL
G
TA
T
GFDFE
L
IDQAGLGH
D
A
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
L
E
VD
QE
KA
Q
A
L
GVSL
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
ML
P
ED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QG
EA
APGT
S
S
G
D
A
MALMENLASK
L
-
-
P
A
G
IGYD
W
T
G
--
MS
YQ
ER
L
SGNQAPA
L
V
A
-
I
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLM
E
KE
----------
G
KGVV
EA
TLM
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
VS
A
T
LLAI
fig|749531.3.peg.2480
Escherichia coli MS 69-1 (1-1018/1034)
M
ANFF
IRRP
IF
AWV
L
----
AI
I
L
M
M
A
G
VLA
I
LQ
LPV
A
QYP
T
I
AP
P
A
V
S
V
S
A
N
YPGA
D
AQ
T
V
Q
D
T
VT
Q
VIE
QN
M
NG
I
D
N
LM
Y
MSS
T
S
DSA
G
SVT
ITL
T
F
Q
S
GT
D
PD
I
A
QV
QVQ
NK
LQ
L
A
TPL
LP
QEVQQQ
G
I
SVE-KSSSS
---
Y
L
MVA
G
FV
S
DNPGTTQD
DI
S
D
Y
V
ASN
V
KDT
LS
RLN
GVG
D
V
QLF
G
AQY-AM
RI
W
LD
A
DL
LN
KYK
L
TPVD
V
IN
QL
KVQ
N
DQIAA
GQLGG
T
P
ALPGQQLNAS
I
I
A
QTR
L
K
N
P
EEF
GK
V
T
L
RVNS
DG
SV
V
R
L
K
DVA
R
VE
L
G
G
E
NYNVI
A
RI
NGK
-
P
A
A
G
LG
I
K
L
AT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPF
FP
Q
G
M
K
VLYP
YDTT
PF
V
QL
SI
H
E
VVKT
L
F
EAI
M
LV
F
LV
M
YLFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
A
I
L
A
A
F
G
Y
S
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
D
KLP
P
KE
A
TE
K
SMS
QIQ
G
AL
VGIAMV
L
S
AVFIPM
A
F
FG
G
ST
G
A
IYR
Q
FSIT
IVS
AM
AL
SV
L
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGSFFGWF
N
TT
F
DHSVNH
----
Y
TNSVG
K
I
L
GSTGRY
L
L
I
Y
A
L
IVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VT
DYY
LKNEKAN
V
E
SVF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
SGDENSAE
A
V
I
H
RA
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VEL
G
TA
T
GFDFE
L
IDQAGLGH
D
A
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
L
E
VD
QE
KA
Q
A
L
GVSL
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
ML
P
ED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TAHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QG
EA
APGT
S
S
G
D
A
MALMENLASQ
L
-
-
P
A
G
IDYD
W
T
G
--
MS
YQ
ER
L
SGNQAPA
L
V
A
-
I
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLM
E
KE
----------
G
KGVV
EA
TLM
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
VS
A
T
LLAI
fig|656379.3.peg.4005
Escherichia coli FVEC1302 (1-1018/1034)
M
ANFF
IRRP
IF
AWV
L
----
AI
I
L
M
M
A
G
ALA
I
LQ
LPV
A
QYP
T
I
AP
P
A
V
S
V
S
A
N
YPGA
D
AQ
T
V
Q
D
T
VT
Q
VIE
QN
M
NG
I
D
N
LM
Y
MSS
T
S
DSA
G
SVT
ITL
T
F
Q
S
GT
D
PD
I
A
QV
QVQ
NK
LQ
L
A
TPL
LP
QEVQQQ
G
I
SVE-KSSSS
---
Y
L
MVA
G
FV
S
DNPDTTQD
DI
S
D
Y
V
ASN
V
KDT
LS
RLN
GVG
D
V
QLF
G
AQY-AM
RI
W
LD
A
DL
LN
KYK
L
TPVD
V
IN
QL
KVQ
N
DQIAA
GQLGG
T
P
ALPGQQLNAS
I
I
A
QTR
L
K
N
P
EEF
GK
V
T
L
RVNS
DG
SV
V
R
L
K
DVA
R
VE
L
G
G
E
NYNVI
A
RI
NGK
-
P
A
A
G
LG
I
K
L
AT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPF
FP
Q
G
M
K
VLYP
YDTT
PF
V
QL
SI
H
E
VVKT
L
F
EAI
M
LV
F
LV
M
YLFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
A
I
L
A
A
F
G
Y
S
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
D
KLP
P
KE
A
TE
K
SMS
QIQ
G
AL
VGIAMV
L
S
AVFIPM
A
F
FG
G
ST
G
A
IYR
Q
FSIT
IVS
AM
AL
SV
L
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWF
N
TT
F
DHSVNH
----
Y
TNSVG
K
I
L
GSTGRY
L
L
I
Y
A
L
IVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VT
DYY
LKNEKAN
V
E
SVF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
SGDENSAE
A
V
I
H
RA
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VEL
G
TA
T
GFDFE
L
IDQAGLGH
D
A
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
L
E
VD
QE
KA
Q
A
L
GVSL
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
ML
P
ED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TAHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QG
EA
APGT
S
S
G
D
A
MALMENLASQ
L
-
-
P
A
G
IGYD
W
T
G
--
MS
YQ
ER
L
SGNQAPA
L
V
A
-
I
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLM
E
KE
----------
G
KGVV
EA
TLM
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
VS
A
T
LLAI
fig|656380.3.peg.3924
Escherichia coli FVEC1412 (1-1018/1034)
M
ANFF
IRRP
IF
AWV
L
----
AI
I
L
M
M
A
G
ALA
I
LQ
LPV
A
QYP
T
I
AP
P
A
V
S
V
S
A
N
YPGA
D
AQ
T
V
Q
D
T
VT
Q
VIE
QN
M
NG
I
D
N
LM
Y
MSS
T
S
DSA
G
SVT
ITL
T
F
Q
S
GT
D
PD
I
A
QV
QVQ
NK
LQ
L
A
TPL
LP
QEVQQQ
G
I
SVE-KSSSS
---
Y
L
MVA
G
FV
S
DNPDTTQD
DI
S
D
Y
V
ASN
V
KDT
LS
RLN
GVG
D
V
QLF
G
AQY-AM
RI
W
LD
A
DL
LN
KYK
L
TPVD
V
IN
QL
KVQ
N
DQIAA
GQLGG
T
P
ALPGQQLNAS
I
I
A
QTR
L
K
N
P
EEF
GK
V
T
L
RVNS
DG
SV
V
R
L
K
DVA
R
VE
L
G
G
E
NYNVI
A
RI
NGK
-
P
A
A
G
LG
I
K
L
AT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPF
FP
Q
G
M
K
VLYP
YDTT
PF
V
QL
SI
H
E
VVKT
L
F
EAI
M
LV
F
LV
M
YLFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
A
I
L
A
A
F
G
Y
S
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
D
KLP
P
KE
A
TE
K
SMS
QIQ
G
AL
VGIAMV
L
S
AVFIPM
A
F
FG
G
ST
G
A
IYR
Q
FSIT
IVS
AM
AL
SV
L
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWF
N
TT
F
DHSVNH
----
Y
TNSVG
K
I
L
GSTGRY
L
L
I
Y
A
L
IVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VT
DYY
LKNEKAN
V
E
SVF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
SGDENSAE
A
V
I
H
RA
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VEL
G
TA
T
GFDFE
L
IDQAGLGH
D
A
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
L
E
VD
QE
KA
Q
A
L
GVSL
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
ML
P
ED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TAHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QG
EA
APGT
S
S
G
D
A
MALMENLASQ
L
-
-
P
A
G
IGYD
W
T
G
--
MS
YQ
ER
L
SGNQAPA
L
V
A
-
I
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLM
E
KE
----------
G
KGVV
EA
TLM
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
VS
A
T
LLAI
fig|749549.3.peg.2017
Escherichia coli MS 198-1 (1-1018/1034)
M
ANFF
IRRP
IF
AWV
L
----
AI
I
L
M
M
A
G
ALA
I
LQ
LPV
A
QYP
T
I
AP
P
A
V
S
V
S
A
N
YPGA
D
AQ
T
V
Q
D
T
VT
Q
VIE
QN
M
NG
I
D
N
LM
Y
MSS
T
S
DSA
G
SVT
ITL
T
F
Q
S
GT
D
PD
I
A
QV
QVQ
NK
LQ
L
A
TPL
LP
QEVQQQ
G
I
SVE-KSSSS
---
Y
L
MVA
G
FV
S
DNPDTTQD
DI
S
D
Y
V
ASN
V
KDT
LS
RLN
GVG
D
V
QLF
G
AQY-AM
RI
W
LD
A
DL
LN
KYK
L
TPVD
V
IN
QL
KVQ
N
DQIAA
GQLGG
T
P
ALPGQQLNAS
I
I
A
QTR
L
K
N
P
EEF
GK
V
T
L
RVNS
DG
SV
V
R
L
K
DVA
R
VE
L
G
G
E
NYNVI
A
RI
NGK
-
P
A
A
G
LG
I
K
L
AT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPF
FP
Q
G
M
K
VLYP
YDTT
PF
V
QL
SI
H
E
VVKT
L
F
EAI
M
LV
F
LV
M
YLFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
A
I
L
A
A
F
G
Y
S
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
D
KLP
P
KE
A
TE
K
SMS
QIQ
G
AL
VGIAMV
L
S
AVFIPM
A
F
FG
G
ST
G
A
IYR
Q
FSIT
IVS
AM
AL
SV
L
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWF
N
TT
F
DHSVNH
----
Y
TNSVG
K
I
L
GSTGRY
L
L
I
Y
A
L
IVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VT
DYY
LKNEKAN
V
E
SVF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
SGDENSAE
A
V
I
H
RA
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VEL
G
TA
T
GFDFE
L
IDQAGLGH
D
A
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
L
E
VD
QE
KA
Q
A
L
GVSL
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
ML
P
ED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TAHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QG
EA
APGT
S
S
G
D
A
MALMENLASQ
L
-
-
P
A
G
IGYD
W
T
G
--
MS
YQ
ER
L
SGNQAPA
L
V
A
-
I
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLM
E
KE
----------
G
KGVV
EA
TLM
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
VS
A
T
LLAI
fig|199310.1.peg.3941
Escherichia coli CFT073 (1-1018/1034)
M
ANFF
IRRP
IF
AWV
L
----
AI
I
L
M
I
A
G
ALA
I
LQ
LPV
A
QYP
T
I
AP
P
A
V
S
V
S
A
N
YPGA
D
AQ
T
V
Q
D
T
VT
Q
VIE
QN
M
NG
I
D
N
LM
Y
MSS
T
S
DSA
G
SVT
ITL
T
F
Q
S
GT
D
PD
I
A
QV
QVQ
NK
LQ
L
A
TPL
LP
QEVQQQ
G
I
SVE-KSSSS
---
Y
L
MVA
G
FV
S
DNPGTTQD
DI
S
D
Y
V
ASN
V
KDT
LS
RLN
GVG
D
V
QLF
G
AQY-AM
RI
W
LD
A
DL
LN
KYK
L
TPVD
V
IN
QL
KVQ
N
DQIAA
GQLGG
T
P
ALPGQQLNAS
I
I
A
QTR
L
K
N
P
EEF
GK
V
T
L
RVNS
DG
SV
V
R
L
K
DVA
R
VE
L
G
G
E
NYNVI
A
RI
NGK
-
P
A
A
G
LG
I
K
L
AT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPF
FP
Q
G
M
K
VLYP
YDTT
PF
V
QL
SI
Q
E
VVKT
L
F
EAI
M
LV
F
LV
M
YLFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
A
I
L
A
A
F
G
Y
S
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
D
KLP
P
RE
A
TE
K
SMS
QIQ
G
AL
VGIAMV
L
S
AVFIPM
A
F
FG
G
ST
G
A
IYR
Q
FSIT
IVS
AM
AL
SV
L
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWF
N
TT
F
DHSVNH
----
Y
TNSVG
K
I
L
GSTGRY
L
L
I
Y
A
L
IVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VT
DYY
LKNEKAN
V
E
SVF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
SGDENSAE
A
V
I
H
RA
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VEL
G
TA
T
GFDFE
L
IDQAGLGH
D
A
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
L
E
VD
QE
KA
Q
A
L
GVSL
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
ML
P
ED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QG
EA
APGT
S
S
G
D
A
MALMENLASK
L
-
-
P
A
G
IGYD
W
T
G
--
MS
YQ
ER
L
SGNQAPA
L
V
A
-
I
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLM
E
KE
----------
G
KGVV
EA
TLM
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
VS
A
T
LLAI
fig|199310.4.peg.3796
Escherichia coli CFT073 (1-1018/1034)
M
ANFF
IRRP
IF
AWV
L
----
AI
I
L
M
I
A
G
ALA
I
LQ
LPV
A
QYP
T
I
AP
P
A
V
S
V
S
A
N
YPGA
D
AQ
T
V
Q
D
T
VT
Q
VIE
QN
M
NG
I
D
N
LM
Y
MSS
T
S
DSA
G
SVT
ITL
T
F
Q
S
GT
D
PD
I
A
QV
QVQ
NK
LQ
L
A
TPL
LP
QEVQQQ
G
I
SVE-KSSSS
---
Y
L
MVA
G
FV
S
DNPGTTQD
DI
S
D
Y
V
ASN
V
KDT
LS
RLN
GVG
D
V
QLF
G
AQY-AM
RI
W
LD
A
DL
LN
KYK
L
TPVD
V
IN
QL
KVQ
N
DQIAA
GQLGG
T
P
ALPGQQLNAS
I
I
A
QTR
L
K
N
P
EEF
GK
V
T
L
RVNS
DG
SV
V
R
L
K
DVA
R
VE
L
G
G
E
NYNVI
A
RI
NGK
-
P
A
A
G
LG
I
K
L
AT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPF
FP
Q
G
M
K
VLYP
YDTT
PF
V
QL
SI
Q
E
VVKT
L
F
EAI
M
LV
F
LV
M
YLFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
A
I
L
A
A
F
G
Y
S
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
D
KLP
P
RE
A
TE
K
SMS
QIQ
G
AL
VGIAMV
L
S
AVFIPM
A
F
FG
G
ST
G
A
IYR
Q
FSIT
IVS
AM
AL
SV
L
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWF
N
TT
F
DHSVNH
----
Y
TNSVG
K
I
L
GSTGRY
L
L
I
Y
A
L
IVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VT
DYY
LKNEKAN
V
E
SVF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
SGDENSAE
A
V
I
H
RA
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VEL
G
TA
T
GFDFE
L
IDQAGLGH
D
A
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
L
E
VD
QE
KA
Q
A
L
GVSL
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
ML
P
ED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QG
EA
APGT
S
S
G
D
A
MALMENLASK
L
-
-
P
A
G
IGYD
W
T
G
--
MS
YQ
ER
L
SGNQAPA
L
V
A
-
I
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLM
E
KE
----------
G
KGVV
EA
TLM
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
VS
A
T
LLAI
fig|1040638.4.peg.1852
Escherichia coli O104:H4 str. LB226692 (1-1018/1034)
M
ANFF
IRRP
IF
AWV
L
----
AI
I
L
M
M
A
G
ALA
I
LQ
LPV
A
QYP
T
I
AP
P
A
V
S
V
S
A
N
YPGA
D
AQ
T
V
Q
D
T
VT
Q
VIE
QN
M
NG
I
D
N
LM
Y
MSS
T
S
DSA
G
SVT
ITL
T
F
Q
S
GT
D
PD
I
A
QV
QVQ
NK
LQ
L
A
TPL
LP
QEVQQQ
G
I
SVE-KSSSS
---
Y
L
MVA
G
FV
S
DNPDTTQD
DI
S
D
Y
V
ASN
V
KDT
LS
RLN
GVG
D
V
QLF
G
AQY-AM
RI
W
LD
A
DL
LN
KYK
L
TPVD
V
IN
QL
KVQ
N
DQIAA
GQLGG
T
P
ALPGQQLNAS
I
I
A
QTR
L
K
N
P
EEF
GK
V
T
L
RVNS
DG
SV
V
R
L
K
DVA
R
VE
L
G
G
E
NYNVI
A
RI
NGK
-
P
A
A
G
LG
I
K
L
AT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPF
FP
Q
G
M
K
VLYP
YDTT
PF
V
QL
SI
H
E
VVKT
L
F
EAI
M
LV
F
LV
M
YLFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
A
I
L
A
A
F
G
Y
S
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
D
KLP
P
KE
A
TE
K
SMS
QIQ
G
AL
VGIAMV
L
S
AVFIPM
A
F
FG
G
ST
G
A
IYR
Q
FSIT
IVS
AM
AL
SV
L
VAL
I
LTP
A
LCA
TL
L
KPTSAEHHENKGGFFGWF
N
TT
F
DHSVNH
----
Y
TNSVG
K
I
L
GSTGRY
L
L
I
Y
A
L
IVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VT
DYY
LKNEKAN
V
E
SVF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
NSDENSAE
A
V
I
H
RA
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VEL
G
TA
T
GFDFE
L
IDQAGLGH
D
A
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
L
E
VD
QE
KA
Q
A
L
GVSL
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
ML
P
ED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QG
EA
APGT
S
S
G
D
A
MALMENLASK
L
-
-
P
A
G
IGYD
W
T
G
--
MS
YQ
ER
L
SGNQAPA
L
V
A
-
I
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLM
E
KE
----------
G
KGVV
EA
TLM
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
VS
A
T
LLAI
fig|331111.3.peg.1417
Escherichia coli E24377A (1-1018/1034)
M
ANFF
IRRP
IF
AWV
L
----
AI
I
L
M
M
A
G
ALA
I
LQ
LPV
A
QYP
T
I
AP
P
A
V
S
V
S
A
N
YPGA
D
AQ
T
V
Q
D
T
VT
Q
VIE
QN
M
NG
I
D
N
LM
Y
MSS
T
S
DSA
G
SVT
ITL
T
F
Q
S
GT
D
PD
I
A
QV
QVQ
NK
LQ
L
A
TPL
LP
QEVQQQ
G
I
SVE-KSSSS
---
Y
L
MVA
G
FV
S
DNPDTTQD
DI
S
D
Y
V
ASN
V
KDT
LS
RLN
GVG
D
V
QLF
G
AQY-AM
RI
W
LD
A
DL
LN
KYK
L
TPVD
V
IN
QL
KVQ
N
DQIAA
GQLGG
T
P
ALPGQQLNAS
I
I
A
QTR
L
K
N
P
EEF
GK
V
T
L
RVNS
DG
SV
V
R
L
K
DVA
R
VE
L
G
G
E
NYNVI
A
RI
NGK
-
P
A
A
G
LG
I
K
L
AT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPF
FP
Q
G
M
K
VLYP
YDTT
PF
V
QL
SI
H
E
VVKT
L
F
EAI
M
LV
F
LV
M
YLFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
A
I
L
A
A
F
G
Y
S
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
D
KLP
P
KE
A
TE
K
SMS
QIQ
G
AL
VGIAMV
L
S
AVFIPM
A
F
FG
G
ST
G
A
IYR
Q
FSIT
IVS
AM
AL
SV
L
VAL
I
LTP
A
LCA
TL
L
KPTSAEHHENKGGFFGWF
N
TT
F
DHSVNH
----
Y
TNSVG
K
I
L
GSTGRY
L
L
I
Y
A
L
IVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VT
DYY
LKNEKAN
V
E
SVF
TVN
S
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
NGDENSAE
A
V
I
H
RA
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VEL
G
TA
T
GFDFE
L
IDQAGLGH
D
A
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
L
E
VD
QE
KA
Q
A
L
GVSL
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
ML
P
ED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QG
EA
APGT
S
S
G
D
A
MALMENLASK
L
-
-
P
A
G
IGYD
W
T
G
--
MS
YQ
ER
L
SGNQAPA
L
V
A
-
I
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLM
E
KE
----------
G
KGVV
EA
TLM
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
VS
A
T
LLAI
fig|656408.3.peg.3689
Escherichia coli H591 (1-1018/1034)
M
ANFF
IRRP
IF
AWV
L
----
AI
I
L
M
M
A
G
ALA
I
LQ
LPV
A
QYP
T
I
AP
P
A
V
S
V
S
A
N
YPGA
D
AQ
T
V
Q
D
T
VT
Q
VIE
QN
M
NG
I
D
N
LM
Y
MSS
T
S
DSA
G
SVT
ITL
T
F
Q
S
GT
D
PD
I
A
QV
QVQ
NK
LQ
L
A
TPL
LP
QEVQQQ
G
I
SVE-KSSSS
---
Y
L
MVA
G
FV
S
DNPDTTQD
DI
S
D
Y
V
ASN
V
KDT
LS
RLN
GVG
D
V
QLF
G
AQY-AM
RI
W
LD
A
DL
LN
KYK
L
TPVD
V
IN
QL
KVQ
N
DQIAA
GQLGG
T
P
ALPGQQLNAS
I
I
A
QTR
L
K
N
P
EEF
GK
V
T
L
RVNS
DG
SV
V
R
L
K
DVA
R
VE
L
G
G
E
NYNVI
A
RI
NGK
-
P
A
A
G
LG
I
K
L
AT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPF
FP
Q
G
M
K
VLYP
YDTT
PF
V
QL
SI
H
E
VVKT
L
F
EAI
M
LV
F
LV
M
YLFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
A
I
L
A
A
F
G
Y
S
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
D
KLP
P
KE
A
TE
K
SMS
QIQ
G
AL
VGIAMV
L
S
AVFIPM
A
F
FG
G
ST
G
A
IYR
Q
FSIT
IVS
AM
AL
SV
L
VAL
I
LTP
A
LCA
TL
L
KPTSAEHHENKGGFFGWF
N
TT
F
DHSVNH
----
Y
TNSVG
K
I
L
GSTGRY
L
L
I
Y
A
L
IVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VT
DYY
LKNEKAN
V
E
SVF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
NSDENSAE
A
V
I
H
RA
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VEL
G
TA
T
GFDFE
L
IDQAGLGH
D
A
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
L
E
VD
QE
KA
Q
A
L
GVSL
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
ML
P
ED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QG
EA
APGT
S
S
G
D
A
MALMENLASK
L
-
-
P
A
G
IGYD
W
T
G
--
MS
YQ
ER
L
SGNQAPA
L
V
A
-
I
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLM
E
KE
----------
G
KGVV
EA
TLM
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
VS
A
T
LLAI
fig|595495.4.peg.650
Escherichia coli KO11 (1-1018/1034)
M
ANFF
IRRP
IF
AWV
L
----
AI
I
L
M
M
A
G
ALA
I
LQ
LPV
A
QYP
T
I
AP
P
A
V
S
V
S
A
N
YPGA
D
AQ
T
V
Q
D
T
VT
Q
VIE
QN
M
NG
I
D
N
LM
Y
MSS
T
S
DSA
G
SVT
ITL
T
F
Q
S
GT
D
PD
I
A
QV
QVQ
NK
LQ
L
A
TPL
LP
QEVQQQ
G
I
SVE-KSSSS
---
Y
L
MVA
G
FV
S
DNPDTTQD
DI
S
D
Y
V
ASN
V
KDT
LS
RLN
GVG
D
V
QLF
G
AQY-AM
RI
W
LD
A
DL
LN
KYK
L
TPVD
V
IN
QL
KVQ
N
DQIAA
GQLGG
T
P
ALPGQQLNAS
I
I
A
QTR
L
K
N
P
EEF
GK
V
T
L
RVNS
DG
SV
V
R
L
K
DVA
R
VE
L
G
G
E
NYNVI
A
RI
NGK
-
P
A
A
G
LG
I
K
L
AT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPF
FP
Q
G
M
K
VLYP
YDTT
PF
V
QL
SI
H
E
VVKT
L
F
EAI
M
LV
F
LV
M
YLFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
A
I
L
A
A
F
G
Y
S
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
D
KLP
P
KE
A
TE
K
SMS
QIQ
G
AL
VGIAMV
L
S
AVFIPM
A
F
FG
G
ST
G
A
IYR
Q
FSIT
IVS
AM
AL
SV
L
VAL
I
LTP
A
LCA
TL
L
KPTSAEHHENKGGFFGWF
N
TT
F
DHSVNH
----
Y
TNSVG
K
I
L
GSTGRY
L
L
I
Y
A
L
IVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VT
DYY
LKNEKAN
V
E
SVF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
NSDENSAE
A
V
I
H
RA
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VEL
G
TA
T
GFDFE
L
IDQAGLGH
D
A
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
L
E
VD
QE
KA
Q
A
L
GVSL
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
ML
P
ED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QG
EA
APGT
S
S
G
D
A
MALMENLASK
L
-
-
P
A
G
IGYD
W
T
G
--
MS
YQ
ER
L
SGNQAPA
L
V
A
-
I
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLM
E
KE
----------
G
KGVV
EA
TLM
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
VS
A
T
LLAI
fig|656419.3.peg.4247
Escherichia coli M718 (1-1018/1034)
M
ANFF
IRRP
IF
AWV
L
----
AI
I
L
M
M
A
G
ALA
I
LQ
LPV
A
QYP
T
I
AP
P
A
V
S
V
S
A
N
YPGA
D
AQ
T
V
Q
D
T
VT
Q
VIE
QN
M
NG
I
D
N
LM
Y
MSS
T
S
DSA
G
SVT
ITL
T
F
Q
S
GT
D
PD
I
A
QV
QVQ
NK
LQ
L
A
TPL
LP
QEVQQQ
G
I
SVE-KSSSS
---
Y
L
MVA
G
FV
S
DNPDTTQD
DI
S
D
Y
V
ASN
V
KDT
LS
RLN
GVG
D
V
QLF
G
AQY-AM
RI
W
LD
A
DL
LN
KYK
L
TPVD
V
IN
QL
KVQ
N
DQIAA
GQLGG
T
P
ALPGQQLNAS
I
I
A
QTR
L
K
N
P
EEF
GK
V
T
L
RVNS
DG
SV
V
R
L
K
DVA
R
VE
L
G
G
E
NYNVI
A
RI
NGK
-
P
A
A
G
LG
I
K
L
AT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPF
FP
Q
G
M
K
VLYP
YDTT
PF
V
QL
SI
H
E
VVKT
L
F
EAI
M
LV
F
LV
M
YLFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
A
I
L
A
A
F
G
Y
S
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
D
KLP
P
KE
A
TE
K
SMS
QIQ
G
AL
VGIAMV
L
S
AVFIPM
A
F
FG
G
ST
G
A
IYR
Q
FSIT
IVS
AM
AL
SV
L
VAL
I
LTP
A
LCA
TL
L
KPTSAEHHENKGGFFGWF
N
TT
F
DHSVNH
----
Y
TNSVG
K
I
L
GSTGRY
L
L
I
Y
A
L
IVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VT
DYY
LKNEKAN
V
E
SVF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
SGDENSAE
A
V
I
H
RA
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VEL
G
TA
T
GFDFE
L
IDQAGLGH
D
A
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
L
E
VD
QE
KA
Q
A
L
GVSL
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
ML
P
ED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QG
EA
APGT
S
S
G
D
A
MALMENLASK
L
-
-
P
A
G
IGYD
W
T
G
--
MS
YQ
ER
L
SGNQAPA
L
V
A
-
I
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLM
E
KE
----------
G
KGVV
EA
TLM
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
VS
A
T
LLAI
fig|679207.4.peg.2470
Escherichia coli MS 107-1 (1-1018/1034)
M
ANFF
IRRP
IF
AWV
L
----
AI
I
L
M
M
A
G
ALA
I
LQ
LPV
A
QYP
T
I
AP
P
A
V
S
V
S
A
N
YPGA
D
AQ
T
V
Q
D
T
VT
Q
VIE
QN
M
NG
I
D
N
LM
Y
MSS
T
S
DSA
G
SVT
ITL
T
F
Q
S
GT
D
PD
I
A
QV
QVQ
NK
LQ
L
A
TPL
LP
QEVQQQ
G
I
SVE-KSSSS
---
Y
L
MVA
G
FV
S
DNPDTTQD
DI
S
D
Y
V
ASN
V
KDT
LS
RLN
GVG
D
V
QLF
G
AQY-AM
RI
W
LD
A
DL
LN
KYK
L
TPVD
V
IN
QL
KVQ
N
DQIAA
GQLGG
T
P
ALPGQQLNAS
I
I
A
QTR
L
K
N
P
EEF
GK
V
T
L
RVNS
DG
SV
V
R
L
K
DVA
R
VE
L
G
G
E
NYNVI
A
RI
NGK
-
P
A
A
G
LG
I
K
L
AT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPF
FP
Q
G
M
K
VLYP
YDTT
PF
V
QL
SI
H
E
VVKT
L
F
EAI
M
LV
F
LV
M
YLFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
A
I
L
A
A
F
G
Y
S
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
D
KLP
P
KE
A
TE
K
SMS
QIQ
G
AL
VGIAMV
L
S
AVFIPM
A
F
FG
G
ST
G
A
IYR
Q
FSIT
IVS
AM
AL
SV
L
VAL
I
LTP
A
LCA
TL
L
KPTSAEHHENKGGFFGWF
N
TT
F
DHSVNH
----
Y
TNSVG
K
I
L
GSTGRY
L
L
I
Y
A
L
IVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VT
DYY
LKNEKAN
V
E
SVF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
NSDENSAE
A
V
I
H
RA
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VEL
G
TA
T
GFDFE
L
IDQAGLGH
D
A
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
L
E
VD
QE
KA
Q
A
L
GVSL
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
ML
P
ED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QG
EA
APGT
S
S
G
D
A
MALMENLASK
L
-
-
P
A
G
IGYD
W
T
G
--
MS
YQ
ER
L
SGNQAPA
L
V
A
-
I
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLM
E
KE
----------
G
KGVV
EA
TLM
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
VS
A
T
LLAI
fig|679206.4.peg.4698
Escherichia coli MS 119-7 (1-1018/1034)
M
ANFF
IRRP
IF
AWV
L
----
AI
I
L
M
M
A
G
ALA
I
LQ
LPV
A
QYP
T
I
AP
P
A
V
S
V
S
A
N
YPGA
D
AQ
T
V
Q
D
T
VT
Q
VIE
QN
M
NG
I
D
N
LM
Y
MSS
T
S
DSA
G
SVT
ITL
T
F
Q
S
GT
D
PD
I
A
QV
QVQ
NK
LQ
L
A
TPL
LP
QEVQQQ
G
I
SVE-KSSSS
---
Y
L
MVA
G
FV
S
DNPDTTQD
DI
S
D
Y
V
ASN
V
KDT
LS
RLN
GVG
D
V
QLF
G
AQY-AM
RI
W
LD
A
DL
LN
KYK
L
TPVD
V
IN
QL
KVQ
N
DQIAA
GQLGG
T
P
ALPGQQLNAS
I
I
A
QTR
L
K
N
P
EEF
GK
V
T
L
RVNS
DG
SV
V
R
L
K
DVA
R
VE
L
G
G
E
NYNVI
A
RI
NGK
-
P
A
A
G
LG
I
K
L
AT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPF
FP
Q
G
M
K
VLYP
YDTT
PF
V
QL
SI
H
E
VVKT
L
F
EAI
M
LV
F
LV
M
YLFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
A
I
L
A
A
F
G
Y
S
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
D
KLP
P
KE
A
TE
K
SMS
QIQ
G
AL
VGIAMV
L
S
AVFIPM
A
F
FG
G
ST
G
A
IYR
Q
FSIT
IVS
AM
AL
SV
L
VAL
I
LTP
A
LCA
TL
L
KPTSAEHHENKGGFFGWF
N
TT
F
DHSVNH
----
Y
TNSVG
K
I
L
GSTGRY
L
L
I
Y
A
L
IVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VT
DYY
LKNEKAN
V
E
SVF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
NSDENSAE
A
V
I
H
RA
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VEL
G
TA
T
GFDFE
L
IDQAGLGH
D
A
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
L
E
VD
QE
KA
Q
A
L
GVSL
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
ML
P
ED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QG
EA
APGT
S
S
G
D
A
MALMENLASK
L
-
-
P
A
G
IGYD
W
T
G
--
MS
YQ
ER
L
SGNQAPA
L
V
A
-
I
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLM
E
KE
----------
G
KGVV
EA
TLM
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
VS
A
T
LLAI
fig|679204.3.peg.1000
Escherichia coli MS 145-7 (1-1018/1034)
M
ANFF
IRRP
IF
AWV
L
----
AI
I
L
M
M
A
G
ALA
I
LQ
LPV
A
QYP
T
I
AP
P
A
V
S
V
S
A
N
YPGA
D
AQ
T
V
Q
D
T
VT
Q
VIE
QN
M
NG
I
D
N
LM
Y
MSS
T
S
DSA
G
SVT
ITL
T
F
Q
S
GT
D
PD
I
A
QV
QVQ
NK
LQ
L
A
TPL
LP
QEVQQQ
G
I
SVE-KSSSS
---
Y
L
MVA
G
FV
S
DNPDTTQD
DI
S
D
Y
V
ASN
V
KDT
LS
RLN
GVG
D
V
QLF
G
AQY-AM
RI
W
LD
A
DL
LN
KYK
L
TPVD
V
IN
QL
KVQ
N
DQIAA
GQLGG
T
P
ALPGQQLNAS
I
I
A
QTR
L
K
N
P
EEF
GK
V
T
L
RVNS
DG
SV
V
R
L
K
DVA
R
VE
L
G
G
E
NYNVI
A
RI
NGK
-
P
A
A
G
LG
I
K
L
AT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPF
FP
Q
G
M
K
VLYP
YDTT
PF
V
QL
SI
H
E
VVKT
L
F
EAI
M
LV
F
LV
M
YLFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
A
I
L
A
A
F
G
Y
S
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
D
KLP
P
KE
A
TE
K
SMS
QIQ
G
AL
VGIAMV
L
S
AVFIPM
A
F
FG
G
ST
G
A
IYR
Q
FSIT
IVS
AM
AL
SV
L
VAL
I
LTP
A
LCA
TL
L
KPTSAEHHENKGGFFGWF
N
TT
F
DHSVNH
----
Y
TNSVG
K
I
L
GSTGRY
L
L
I
Y
A
L
IVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VT
DYY
LKNEKAN
V
E
SVF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
NSDENSAE
A
V
I
H
RA
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VEL
G
TA
T
GFDFE
L
IDQAGLGH
D
A
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
L
E
VD
QE
KA
Q
A
L
GVSL
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
ML
P
ED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QG
EA
APGT
S
S
G
D
A
MALMENLASK
L
-
-
P
A
G
IGYD
W
T
G
--
MS
YQ
ER
L
SGNQAPA
L
V
A
-
I
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLM
E
KE
----------
G
KGVV
EA
TLM
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
VS
A
T
LLAI
fig|749545.3.peg.3813
Escherichia coli MS 182-1 (1-1018/1034)
M
ANFF
IRRP
IF
AWV
L
----
AI
I
L
M
M
A
G
ALA
I
LQ
LPV
A
QYP
T
I
AP
P
A
V
S
V
S
A
N
YPGA
D
AQ
T
V
Q
D
T
VT
Q
VIE
QN
M
NG
I
D
N
LM
Y
MSS
T
S
DSA
G
SVT
ITL
T
F
Q
S
GT
D
PD
I
A
QV
QVQ
NK
LQ
L
A
TPL
LP
QEVQQQ
G
I
SVE-KSSSS
---
Y
L
MVA
G
FV
S
DNPDTTQD
DI
S
D
Y
V
ASN
V
KDT
LS
RLN
GVG
D
V
QLF
G
AQY-AM
RI
W
LD
A
DL
LN
KYK
L
TPVD
V
IN
QL
KVQ
N
DQIAA
GQLGG
T
P
ALPGQQLNAS
I
I
A
QTR
L
K
N
P
EEF
GK
V
T
L
RVNS
DG
SV
V
R
L
K
DVA
R
VE
L
G
G
E
NYNVI
A
RI
NGK
-
P
A
A
G
LG
I
K
L
AT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPF
FP
Q
G
M
K
VLYP
YDTT
PF
V
QL
SI
H
E
VVKT
L
F
EAI
M
LV
F
LV
M
YLFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
A
I
L
A
A
F
G
Y
S
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
D
KLP
P
KE
A
TE
K
SMS
QIQ
G
AL
VGIAMV
L
S
AVFIPM
A
F
FG
G
ST
G
A
IYR
Q
FSIT
IVS
AM
AL
SV
L
VAL
I
LTP
A
LCA
TL
L
KPTSAEHHENKGGFFGWF
N
TT
F
DHSVNH
----
Y
TNSVG
K
I
L
GSTGRY
L
L
I
Y
A
L
IVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VT
DYY
LKNEKAN
V
E
SVF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
NGDENSAE
A
V
I
H
RA
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VEL
G
TA
T
GFDFE
L
IDQAGLGH
D
A
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
L
E
VD
QE
KA
Q
A
L
GVSL
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
ML
P
ED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QG
EA
APGT
S
S
G
D
A
MALMENLASK
L
-
-
P
A
G
IGYD
W
T
G
--
MS
YQ
ER
L
SGNQAPA
L
V
A
-
I
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLM
E
KE
----------
G
KGVV
EA
TLM
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
VS
A
T
LLAI
fig|749532.3.peg.1210
Escherichia coli MS 78-1 (1-1018/1034)
M
ANFF
IRRP
IF
AWV
L
----
AI
I
L
M
M
A
G
ALA
I
LQ
LPV
A
QYP
T
I
AP
P
A
V
S
V
S
A
N
YPGA
D
AQ
T
V
Q
D
T
VT
Q
VIE
QN
M
NG
I
D
N
LM
Y
MSS
T
S
DSA
G
SVT
ITL
T
F
Q
S
GT
D
PD
I
A
QV
QVQ
NK
LQ
L
A
TPL
LP
QEVQQQ
G
I
SVE-KSSSS
---
Y
L
MVA
G
FV
S
DNPDTTQD
DI
S
D
Y
V
ASN
V
KDT
LS
RLN
GVG
D
V
QLF
G
AQY-AM
RI
W
LD
A
DL
LN
KYK
L
TPVD
V
IN
QL
KVQ
N
DQIAA
GQLGG
T
P
ALPGQQLNAS
I
I
A
QTR
L
K
N
P
EEF
GK
V
T
L
RVNS
DG
SV
V
R
L
K
DVA
R
VE
L
G
G
E
NYNVI
A
RI
NGK
-
P
A
A
G
LG
I
K
L
AT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPF
FP
Q
G
M
K
VLYP
YDTT
PF
V
QL
SI
H
E
VVKT
L
F
EAI
M
LV
F
LV
M
YLFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
A
I
L
A
A
F
G
Y
S
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
D
KLP
P
KE
A
TE
K
SMS
QIQ
G
AL
VGIAMV
L
S
AVFIPM
A
F
FG
G
ST
G
A
IYR
Q
FSIT
IVS
AM
AL
SV
L
VAL
I
LTP
A
LCA
TL
L
KPTSAEHHENKGGFFGWF
N
TT
F
DHSVNH
----
Y
TNSVG
K
I
L
GSTGRY
L
L
I
Y
A
L
IVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VT
DYY
LKNEKAN
V
E
SVF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
NGDENSAE
A
V
I
H
RA
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VEL
G
TA
T
GFDFE
L
IDQAGLGH
D
A
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
L
E
VD
QE
KA
Q
A
L
GVSL
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
ML
P
ED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QG
EA
APGT
S
S
G
D
A
MALMENLASK
L
-
-
P
A
G
IGYD
W
T
G
--
MS
YQ
ER
L
SGNQAPA
L
V
A
-
I
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLM
E
KE
----------
G
KGVV
EA
TLM
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
VS
A
T
LLAI
fig|656443.3.peg.4164
Escherichia coli TA271 (1-1018/1034)
M
ANFF
IRRP
IF
AWV
L
----
AI
I
L
M
M
A
G
ALA
I
LQ
LPV
A
QYP
T
I
AP
P
A
V
S
V
S
A
N
YPGA
D
AQ
T
V
Q
D
T
VT
Q
VIE
QN
M
NG
I
D
N
LM
Y
MSS
T
S
DSA
G
SVT
ITL
T
F
Q
S
GT
D
PD
I
A
QV
QVQ
NK
LQ
L
A
TPL
LP
QEVQQQ
G
I
SVE-KSSSS
---
Y
L
MVA
G
FV
S
DNPDTTQD
DI
S
D
Y
V
ASN
V
KDT
LS
RLN
GVG
D
V
QLF
G
AQY-AM
RI
W
LD
A
DL
LN
KYK
L
TPVD
V
IN
QL
KVQ
N
DQIAA
GQLGG
T
P
ALPGQQLNAS
I
I
A
QTR
L
K
N
P
EEF
GK
V
T
L
RVNS
DG
SV
V
R
L
K
DVA
R
VE
L
G
G
E
NYNVI
A
RI
NGK
-
P
A
A
G
LG
I
K
L
AT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPF
FP
Q
G
M
K
VLYP
YDTT
PF
V
QL
SI
H
E
VVKT
L
F
EAI
M
LV
F
LV
M
YLFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
A
I
L
A
A
F
G
Y
S
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
D
KLP
P
KE
A
TE
K
SMS
QIQ
G
AL
VGIAMV
L
S
AVFIPM
A
F
FG
G
ST
G
A
IYR
Q
FSIT
IVS
AM
AL
SV
L
VAL
I
LTP
A
LCA
TL
L
KPTSAEHHENKGGFFGWF
N
TT
F
DHSVNH
----
Y
TNSVG
K
I
L
GSTGRY
L
L
I
Y
A
L
IVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VT
DYY
LKNEKAN
V
E
SVF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
NSDENSAE
A
V
I
H
RA
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VEL
G
TA
T
GFDFE
L
IDQAGLGH
D
A
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
L
E
VD
QE
KA
Q
A
L
GVSL
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
ML
P
ED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QG
EA
APGT
S
S
G
D
A
MALMENLASK
L
-
-
P
A
G
IGYD
W
T
G
--
MS
YQ
ER
L
SGNQAPA
L
V
A
-
I
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLM
E
KE
----------
G
KGVV
EA
TLM
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
VS
A
T
LLAI
fig|566546.3.peg.4708
Escherichia coli W (1-1018/1034)
M
ANFF
IRRP
IF
AWV
L
----
AI
I
L
M
M
A
G
ALA
I
LQ
LPV
A
QYP
T
I
AP
P
A
V
S
V
S
A
N
YPGA
D
AQ
T
V
Q
D
T
VT
Q
VIE
QN
M
NG
I
D
N
LM
Y
MSS
T
S
DSA
G
SVT
ITL
T
F
Q
S
GT
D
PD
I
A
QV
QVQ
NK
LQ
L
A
TPL
LP
QEVQQQ
G
I
SVE-KSSSS
---
Y
L
MVA
G
FV
S
DNPDTTQD
DI
S
D
Y
V
ASN
V
KDT
LS
RLN
GVG
D
V
QLF
G
AQY-AM
RI
W
LD
A
DL
LN
KYK
L
TPVD
V
IN
QL
KVQ
N
DQIAA
GQLGG
T
P
ALPGQQLNAS
I
I
A
QTR
L
K
N
P
EEF
GK
V
T
L
RVNS
DG
SV
V
R
L
K
DVA
R
VE
L
G
G
E
NYNVI
A
RI
NGK
-
P
A
A
G
LG
I
K
L
AT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPF
FP
Q
G
M
K
VLYP
YDTT
PF
V
QL
SI
H
E
VVKT
L
F
EAI
M
LV
F
LV
M
YLFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
A
I
L
A
A
F
G
Y
S
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
D
KLP
P
KE
A
TE
K
SMS
QIQ
G
AL
VGIAMV
L
S
AVFIPM
A
F
FG
G
ST
G
A
IYR
Q
FSIT
IVS
AM
AL
SV
L
VAL
I
LTP
A
LCA
TL
L
KPTSAEHHENKGGFFGWF
N
TT
F
DHSVNH
----
Y
TNSVG
K
I
L
GSTGRY
L
L
I
Y
A
L
IVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VT
DYY
LKNEKAN
V
E
SVF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
NSDENSAE
A
V
I
H
RA
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VEL
G
TA
T
GFDFE
L
IDQAGLGH
D
A
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
L
E
VD
QE
KA
Q
A
L
GVSL
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
ML
P
ED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QG
EA
APGT
S
S
G
D
A
MALMENLASK
L
-
-
P
A
G
IGYD
W
T
G
--
MS
YQ
ER
L
SGNQAPA
L
V
A
-
I
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLM
E
KE
----------
G
KGVV
EA
TLM
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
VS
A
T
LLAI
fig|566546.4.peg.3495
Escherichia coli W (1-1018/1034)
M
ANFF
IRRP
IF
AWV
L
----
AI
I
L
M
M
A
G
ALA
I
LQ
LPV
A
QYP
T
I
AP
P
A
V
S
V
S
A
N
YPGA
D
AQ
T
V
Q
D
T
VT
Q
VIE
QN
M
NG
I
D
N
LM
Y
MSS
T
S
DSA
G
SVT
ITL
T
F
Q
S
GT
D
PD
I
A
QV
QVQ
NK
LQ
L
A
TPL
LP
QEVQQQ
G
I
SVE-KSSSS
---
Y
L
MVA
G
FV
S
DNPDTTQD
DI
S
D
Y
V
ASN
V
KDT
LS
RLN
GVG
D
V
QLF
G
AQY-AM
RI
W
LD
A
DL
LN
KYK
L
TPVD
V
IN
QL
KVQ
N
DQIAA
GQLGG
T
P
ALPGQQLNAS
I
I
A
QTR
L
K
N
P
EEF
GK
V
T
L
RVNS
DG
SV
V
R
L
K
DVA
R
VE
L
G
G
E
NYNVI
A
RI
NGK
-
P
A
A
G
LG
I
K
L
AT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPF
FP
Q
G
M
K
VLYP
YDTT
PF
V
QL
SI
H
E
VVKT
L
F
EAI
M
LV
F
LV
M
YLFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
A
I
L
A
A
F
G
Y
S
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
D
KLP
P
KE
A
TE
K
SMS
QIQ
G
AL
VGIAMV
L
S
AVFIPM
A
F
FG
G
ST
G
A
IYR
Q
FSIT
IVS
AM
AL
SV
L
VAL
I
LTP
A
LCA
TL
L
KPTSAEHHENKGGFFGWF
N
TT
F
DHSVNH
----
Y
TNSVG
K
I
L
GSTGRY
L
L
I
Y
A
L
IVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VT
DYY
LKNEKAN
V
E
SVF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
NSDENSAE
A
V
I
H
RA
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VEL
G
TA
T
GFDFE
L
IDQAGLGH
D
A
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
L
E
VD
QE
KA
Q
A
L
GVSL
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
ML
P
ED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QG
EA
APGT
S
S
G
D
A
MALMENLASK
L
-
-
P
A
G
IGYD
W
T
G
--
MS
YQ
ER
L
SGNQAPA
L
V
A
-
I
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLM
E
KE
----------
G
KGVV
EA
TLM
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
VS
A
T
LLAI
fig|340186.3.peg.4745
Escherichia coli E110019 (1-1018/1034)
M
ANFF
IRRP
IF
AWV
L
----
AI
I
L
M
M
A
G
ALA
I
LQ
LPV
A
QYP
T
I
AP
P
A
V
S
V
S
A
N
YPGA
D
AQ
T
V
Q
D
T
VT
Q
VIE
QN
M
NG
I
D
N
LM
Y
MSS
T
S
DSA
G
SVT
ITL
T
F
Q
S
GT
D
PD
I
A
QV
QVQ
NK
LQ
L
A
TPL
LP
QEVQQQ
G
I
SVE-KSSSS
---
Y
L
MVA
G
FV
S
DNPDTTQD
DI
S
D
Y
V
ASN
V
KDT
LS
RLN
GVG
D
V
QLF
G
AQY-AM
RI
W
LD
A
DL
LN
KYK
L
TPVD
V
IN
QL
KVQ
N
DQIAA
GQLGG
T
P
ALPGQQLNAS
I
I
A
QTR
L
K
N
P
EEF
GK
V
T
L
RVNS
DG
SV
V
R
L
K
DVA
R
VE
L
G
G
E
NYNVI
A
RI
NGK
-
P
A
A
G
LG
I
K
L
AT
GAN
ALV
T
AKA
I
KAK
L
AE
L
QPF
FP
Q
G
M
K
VLYP
YDTT
PF
V
QL
SI
H
E
VVKT
L
F
EAI
M
LV
F
LV
M
YLFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
A
I
L
A
A
F
G
Y
S
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
D
KLP
P
KE
A
TE
K
SMS
QIQ
G
AL
VGIAMV
L
S
AVFIPM
A
F
FG
G
ST
G
A
IYR
Q
FSIT
IVS
AM
AL
SV
L
VAL
I
LTP
A
LCA
TL
L
KPTSAEHHENKGGFFGWF
N
TT
F
DHSVNH
----
Y
TNSVG
K
I
L
GSTGRY
L
L
I
Y
A
L
IVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VT
DYY
LKNEKAN
V
E
SVF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
NGDENSAE
A
V
I
H
RA
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VEL
G
TA
T
GFDFE
L
IDQAGLGH
D
A
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
L
E
VD
QE
KA
Q
A
L
GVSL
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
ML
P
ED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
GS
PR
L
ERY
N
AL
P
SME
I
QG
EA
APGT
S
S
G
D
A
MALMENLASK
L
-
-
P
A
G
IGYD
W
T
G
--
MS
YQ
ER
L
SGNQAPA
L
V
A
-
I
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLM
E
KE
----------
G
KGVV
EA
TLM
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
VS
A
T
LLAI
fig|585034.4.peg.3347
Escherichia coli IAI1 (1-1018/1034)
M
ANFF
IRRP
IF
AWV
L
----
AI
I
L
M
M
A
G
ALA
I
LQ
LPV
A
QYP
T
I
AP
P
A
V
S
V
S
A
N
YPGA
D
AQ
T
V
Q
D
T
VT
Q
VIE
QN
M
NG
I
D
N
LM
Y
MSS
T
S
DSA
G
SVT
ITL
T
F
Q
S
GT
D
PD
I
A
QV
QVQ
NK
LQ
L
A
TPL
LP
QEVQQQ
G
I
SVE-KSSSS
---
Y
L
MVA
G
FV
S
DNPDTTQD
DI
S
D
Y
V
ASN
V
KDT
LS
RLN
GVG
D
V
QLF
G
AQY-AM
RI
W
LD
A
DL
LN
KYK
L
TPVD
V
IN
QL
KVQ
N
DQIAA
GQLGG
T
P
ALPGQQLNAS
I
I
A
QTR
L
K
N
P
EEF
GK
V
T
L
RVNS
DG
SV
V
R
L
K
DVA
R
VE
L
G
G
E
NYNVI
A
RI
NGK
-
P
A
A
G
LG
I
K
L
AT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPF
FP
Q
G
M
K
VLYP
YDTT
PF
V
QL
SI
H
E
VVKT
L
F
EAI
M
LV
F
LV
M
YLFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
A
I
L
A
A
F
G
Y
S
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
D
KLP
P
KE
A
TE
K
SMS
QIQ
G
AL
VGIAMV
L
S
AVFIPM
A
F
FG
G
ST
G
A
IYR
Q
FSIT
IVS
AM
AL
SV
L
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWF
N
TT
F
DHSVNH
----
Y
TNSVG
K
I
L
GSTGRY
L
L
VY
A
L
IVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VT
DYY
LKNEKAN
V
E
SVF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
NGDENSAE
A
V
I
H
RA
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VEL
G
TA
T
GFDFE
L
IDQAGLGH
D
A
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
L
E
VD
QE
KA
Q
A
L
GVSL
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
ML
P
ED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QG
EA
APGT
S
S
G
D
A
MALMENLASK
L
-
-
P
A
G
IGYD
W
T
G
--
MS
YQ
ER
L
SGNQAPA
L
V
A
-
I
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLM
E
KE
----------
G
KGVV
EA
TLM
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
VS
A
T
LLAI
fig|550677.3.peg.3822
Escherichia coli B354 (1-1018/1034)
M
ANFF
IRRP
IF
AWV
L
----
AI
I
L
M
M
A
G
VLA
I
LQ
LPV
A
QYP
T
I
AP
P
A
V
S
V
S
A
N
YPGA
D
AQ
T
V
Q
D
T
VT
Q
VIE
QN
M
NG
I
D
N
LM
Y
MSS
T
S
DSA
G
SVT
ITL
T
F
Q
S
GT
D
PD
I
A
QV
QVQ
NK
LQ
L
A
TPL
LP
QEVQQQ
G
I
SVE-KSSSS
---
Y
L
MVA
G
FV
S
DNPGTTQD
DI
S
D
Y
V
ASN
V
KDT
LS
RLN
GVG
D
V
QLF
G
AQY-AM
RI
W
LD
A
DL
LN
KYK
L
TPVD
V
IN
QL
KVQ
N
DQIAA
GQLGG
T
P
ALPGQQLNAS
I
I
A
QTR
L
K
N
P
EEF
GK
V
T
L
RVNS
DG
SV
V
R
L
K
DVA
R
VE
L
G
G
E
NYNVI
A
RI
NGK
-
P
A
A
G
LG
I
K
L
AT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPF
FP
Q
G
M
K
VLYP
YDTT
PF
V
QL
SI
H
E
VVKT
L
F
EAI
M
LV
F
LV
M
YLFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
A
I
L
A
A
F
G
Y
S
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
D
KLP
P
KE
A
TE
K
SMS
QIQ
G
AL
VGIAMV
L
S
AVFIPM
A
F
FG
G
ST
G
A
IYR
Q
FSIT
IVS
AM
AL
SV
L
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWF
N
TT
F
DHSVNH
----
Y
TNSVG
K
I
L
GSTGRY
L
L
I
Y
A
L
IVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VT
DYY
LKNEKAN
V
E
SVF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
SGDENSAE
A
V
I
H
RA
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VEL
G
TA
T
GFDFE
L
IDQAGLGH
D
A
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
L
E
VD
QE
KA
Q
A
L
GVSL
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
ML
P
ED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TAHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QG
EA
APGT
S
S
G
D
A
MALMENLASQ
L
-
-
P
A
G
IGYD
W
T
G
--
MS
YQ
ER
L
SGNQAPA
L
V
A
-
I
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLM
E
KE
----------
G
KGVV
EA
TLM
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
VS
A
T
LLAI
fig|340184.3.peg.4288
Escherichia coli B7A (1-1018/1034)
M
ANFF
IRRP
IF
AWV
L
----
AI
I
L
M
M
A
G
ALA
I
LQ
LPV
A
QYP
T
I
AP
P
A
V
S
V
S
A
N
YPGA
D
AQ
T
V
Q
D
T
VT
Q
VIE
QN
M
NG
I
D
N
LM
Y
MSS
T
S
DSA
G
SVT
ITL
T
F
Q
S
GT
D
PD
I
A
QV
QVQ
NK
LQ
L
A
TPL
LP
QEVQQQ
G
I
SVE-KSSSS
---
Y
L
MVA
G
FV
S
DNPDTTQD
DI
S
D
Y
V
ASN
V
KDT
LS
RLN
GVG
D
V
QLF
G
AQY-AM
RI
W
LD
A
DL
LN
KYK
L
TPVD
V
IN
QL
KVQ
N
DQIAA
GQLGG
T
P
ALPGQQLNAS
I
I
A
QTR
L
K
N
P
EEF
GK
V
T
L
RVNS
DG
SV
V
R
L
K
DVA
R
VE
L
G
G
E
NYNVI
A
RI
NGK
-
P
A
A
G
LG
I
K
L
AT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPF
FP
Q
G
M
K
VLYP
YDTT
PF
V
QL
SI
H
E
VVKT
L
F
EAI
M
LV
F
LV
M
YLFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
A
I
L
A
A
F
G
Y
S
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
D
KLP
P
KE
A
TE
K
SMS
QIQ
G
AL
VGIAMV
L
S
AVFIPM
A
F
FG
G
ST
G
A
IYR
Q
FSIT
IVS
AM
AL
SV
L
VAL
I
LTP
A
LCA
TL
L
KPTSAEHHENKGGFFGWF
N
TT
F
DHSVNH
----
Y
TNSVG
K
I
L
GSTGRY
L
L
I
Y
A
L
IVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VT
DYY
LKNEKAN
V
E
SVF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
NSDENSAE
A
V
I
H
RA
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VEL
G
TA
T
GFDFE
L
IDQAGLGH
D
A
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
L
E
VD
QE
KA
Q
A
L
GVSL
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
ML
P
ED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QG
EA
APGT
S
S
G
D
A
MALMENLASK
L
-
-
P
A
G
IGYD
W
T
G
--
MS
YQ
ER
L
SGNQAPA
L
V
A
-
I
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLM
E
KE
----------
G
KGVV
EA
TLM
A
VHM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
VS
A
T
LLAI
fig|340184.6.peg.4493
Escherichia coli B7A (1-1018/1034)
M
ANFF
IRRP
IF
AWV
L
----
AI
I
L
M
M
A
G
ALA
I
LQ
LPV
A
QYP
T
I
AP
P
A
V
S
V
S
A
N
YPGA
D
AQ
T
V
Q
D
T
VT
Q
VIE
QN
M
NG
I
D
N
LM
Y
MSS
T
S
DSA
G
SVT
ITL
T
F
Q
S
GT
D
PD
I
A
QV
QVQ
NK
LQ
L
A
TPL
LP
QEVQQQ
G
I
SVE-KSSSS
---
Y
L
MVA
G
FV
S
DNPDTTQD
DI
S
D
Y
V
ASN
V
KDT
LS
RLN
GVG
D
V
QLF
G
AQY-AM
RI
W
LD
A
DL
LN
KYK
L
TPVD
V
IN
QL
KVQ
N
DQIAA
GQLGG
T
P
ALPGQQLNAS
I
I
A
QTR
L
K
N
P
EEF
GK
V
T
L
RVNS
DG
SV
V
R
L
K
DVA
R
VE
L
G
G
E
NYNVI
A
RI
NGK
-
P
A
A
G
LG
I
K
L
AT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPF
FP
Q
G
M
K
VLYP
YDTT
PF
V
QL
SI
H
E
VVKT
L
F
EAI
M
LV
F
LV
M
YLFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
A
I
L
A
A
F
G
Y
S
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
D
KLP
P
KE
A
TE
K
SMS
QIQ
G
AL
VGIAMV
L
S
AVFIPM
A
F
FG
G
ST
G
A
IYR
Q
FSIT
IVS
AM
AL
SV
L
VAL
I
LTP
A
LCA
TL
L
KPTSAEHHENKGGFFGWF
N
TT
F
DHSVNH
----
Y
TNSVG
K
I
L
GSTGRY
L
L
I
Y
A
L
IVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VT
DYY
LKNEKAN
V
E
SVF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
NSDENSAE
A
V
I
H
RA
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VEL
G
TA
T
GFDFE
L
IDQAGLGH
D
A
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
L
E
VD
QE
KA
Q
A
L
GVSL
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
ML
P
ED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QG
EA
APGT
S
S
G
D
A
MALMENLASK
L
-
-
P
A
G
IGYD
W
T
G
--
MS
YQ
ER
L
SGNQAPA
L
V
A
-
I
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLM
E
KE
----------
G
KGVV
EA
TLM
A
VHM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
VS
A
T
LLAI
fig|216593.1.peg.4876
Escherichia coli E2348/69 (1-1018/1034)
M
ANFF
IRRP
IF
AWV
L
----
AI
I
L
M
M
A
G
ALA
I
LQ
LPV
A
QYP
T
I
AP
P
A
V
S
V
S
A
N
YPGA
D
AQ
T
V
Q
D
T
VT
Q
VIE
QN
M
NG
I
D
N
LM
Y
MSS
T
S
DSA
G
SVT
ITL
T
F
Q
S
GT
D
PD
I
A
QV
QVQ
NK
LQ
L
A
TPL
LP
QEVQQQ
G
I
SVE-KSSSS
---
Y
L
MVA
G
FV
S
DNPGTTQD
DI
S
D
Y
V
ASN
V
KDT
LS
RLN
GVG
D
V
QLF
G
AQY-AM
RI
W
LD
A
DL
LN
KYK
L
TPVD
V
IN
QL
KVQ
N
DQIAA
GQLGG
T
P
ALPGQQLNAS
I
I
A
QTR
L
K
N
P
EEF
GK
V
T
L
RVNS
DG
SV
V
R
L
K
DVA
R
VE
L
G
G
E
NYNVI
A
RI
NGK
-
P
A
A
G
LG
I
K
L
AT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPF
FP
Q
G
M
K
VLYP
YDTT
PF
V
QL
SI
Q
E
VVKT
L
F
EAI
I
LV
F
LV
M
YLFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
A
I
L
A
A
F
G
Y
S
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
M
I
E
----------
D
KLP
P
KE
A
TE
K
SMS
QIQ
G
AL
VGIAMV
L
S
AVFIPM
A
F
FG
G
ST
G
A
IYR
Q
FSIT
IVS
AM
AL
SV
L
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGAFFGWF
N
TT
F
DHSVNH
----
Y
TNSVG
K
I
L
GSTGRY
L
L
I
Y
A
L
IVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VT
DYY
LKNEKAN
V
E
SVF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
SGDENSAE
A
V
I
H
RA
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VEL
G
TA
T
GFDFE
L
IDQAGLGH
D
A
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
L
E
VD
QE
KA
Q
A
L
GVSL
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
ML
P
ED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QG
EA
APGT
S
S
G
D
A
MALMENLASK
L
-
-
P
A
G
IGYD
W
T
G
--
MS
YQ
ER
L
SGNQAPA
L
V
A
-
I
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLM
E
KE
----------
G
KGVV
EA
TLM
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
VS
A
T
LLAI
fig|656393.3.peg.4313
Escherichia coli H299 (1-1018/1034)
M
ANFF
IRRP
IF
AWV
L
----
AI
I
L
M
M
A
G
ALA
I
LQ
LPV
A
QYP
T
I
AP
P
A
V
S
V
S
A
N
YPGA
D
AQ
T
V
Q
D
T
VT
Q
VIE
QN
M
NG
I
D
N
LM
Y
MSS
T
S
DSA
G
SVT
ITL
T
F
Q
S
GT
D
PD
I
A
QV
QVQ
NK
LQ
L
A
TPL
LP
QEVQQQ
G
I
SVE-KSSSS
---
Y
L
MVA
G
FV
S
DNPGTTQD
DI
S
D
Y
V
ASN
V
KDT
LS
RLN
GVG
D
V
QLF
G
AQY-AM
RI
W
LD
A
DL
LN
KYK
L
TPVD
V
IN
QL
KVQ
N
DQIAA
GQLGG
T
P
ALPGQQLNAS
I
I
A
QTR
L
K
N
P
EEF
GK
V
T
L
RVNS
DG
SV
V
R
L
K
DVA
R
VE
L
G
G
E
NYNVI
A
RI
NGK
-
P
A
A
G
LG
I
K
L
AT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPF
FP
Q
G
M
K
VLYP
YDTT
PF
V
QL
SI
H
E
VVKT
L
F
EAI
M
LV
F
LV
M
YLFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
A
I
L
A
A
F
G
Y
S
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
D
KLP
P
KE
A
TE
K
SMS
QIQ
G
AL
VGIAMV
L
S
AVFIPM
A
F
FG
G
ST
G
A
IYR
Q
FSIT
IVS
AM
AL
SV
L
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWF
N
TT
F
DHSVNH
----
Y
TNSVG
K
I
L
GSTGRY
L
L
I
Y
A
L
IVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VT
DYY
LKNEKAN
V
E
SVF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
SGDENSAE
A
V
I
H
RA
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VEL
G
TA
T
GFDFE
L
IDQAGLGH
D
A
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
L
E
VD
QE
KA
Q
A
L
GVSL
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
ML
P
ED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TAHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QG
EA
APGT
S
S
G
D
A
MALMENLASQ
L
-
-
P
A
G
IGYD
W
T
G
--
MS
YQ
ER
L
SGNQAPA
L
V
A
-
I
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLM
E
KE
----------
G
KGVV
EA
TLM
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
VS
A
T
LLAI
fig|574521.7.peg.3616
Escherichia coli O127:H6 str. E2348/69 (1-1018/1034)
M
ANFF
IRRP
IF
AWV
L
----
AI
I
L
M
M
A
G
ALA
I
LQ
LPV
A
QYP
T
I
AP
P
A
V
S
V
S
A
N
YPGA
D
AQ
T
V
Q
D
T
VT
Q
VIE
QN
M
NG
I
D
N
LM
Y
MSS
T
S
DSA
G
SVT
ITL
T
F
Q
S
GT
D
PD
I
A
QV
QVQ
NK
LQ
L
A
TPL
LP
QEVQQQ
G
I
SVE-KSSSS
---
Y
L
MVA
G
FV
S
DNPGTTQD
DI
S
D
Y
V
ASN
V
KDT
LS
RLN
GVG
D
V
QLF
G
AQY-AM
RI
W
LD
A
DL
LN
KYK
L
TPVD
V
IN
QL
KVQ
N
DQIAA
GQLGG
T
P
ALPGQQLNAS
I
I
A
QTR
L
K
N
P
EEF
GK
V
T
L
RVNS
DG
SV
V
R
L
K
DVA
R
VE
L
G
G
E
NYNVI
A
RI
NGK
-
P
A
A
G
LG
I
K
L
AT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPF
FP
Q
G
M
K
VLYP
YDTT
PF
V
QL
SI
Q
E
VVKT
L
F
EAI
I
LV
F
LV
M
YLFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
A
I
L
A
A
F
G
Y
S
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
M
I
E
----------
D
KLP
P
KE
A
TE
K
SMS
QIQ
G
AL
VGIAMV
L
S
AVFIPM
A
F
FG
G
ST
G
A
IYR
Q
FSIT
IVS
AM
AL
SV
L
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGAFFGWF
N
TT
F
DHSVNH
----
Y
TNSVG
K
I
L
GSTGRY
L
L
I
Y
A
L
IVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VT
DYY
LKNEKAN
V
E
SVF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
SGDENSAE
A
V
I
H
RA
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VEL
G
TA
T
GFDFE
L
IDQAGLGH
D
A
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
L
E
VD
QE
KA
Q
A
L
GVSL
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
ML
P
ED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QG
EA
APGT
S
S
G
D
A
MALMENLASK
L
-
-
P
A
G
IGYD
W
T
G
--
MS
YQ
ER
L
SGNQAPA
L
V
A
-
I
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLM
E
KE
----------
G
KGVV
EA
TLM
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
VS
A
T
LLAI
fig|656437.3.peg.3690
Escherichia coli TA143 (1-1018/1034)
M
ANFF
IRRP
IF
AWV
L
----
AI
I
L
M
M
A
G
VLA
I
LQ
LPV
A
QYP
T
I
AP
P
A
V
S
V
S
A
N
YPGA
D
AQ
T
V
Q
D
T
VT
Q
VIE
QN
M
NG
I
D
N
LM
Y
MSS
T
S
DSA
G
SVT
ITL
T
F
Q
S
GT
D
PD
I
A
QV
QVQ
NK
LQ
L
A
TPL
LP
QEVQQQ
G
I
SVE-KSSSS
---
Y
L
MVA
G
FV
S
DNPGTTQD
DI
S
D
Y
V
ASN
V
KDT
LS
RLN
GVG
D
V
QLF
G
AQY-AM
RI
W
LD
A
DL
LN
KYK
L
TPVD
V
IN
QL
KVQ
N
DQIAA
GQLGG
T
P
ALPGQQLNAS
I
I
A
QTR
L
K
N
P
EEF
GK
V
T
L
RVNS
DG
SV
V
R
L
K
DVA
R
VE
L
G
G
E
NYNVI
A
RI
NGK
-
P
A
A
G
LG
I
K
L
AT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPF
FP
Q
G
M
K
VLYP
YDTT
PF
V
QL
SI
H
E
VVKT
L
F
EAI
M
LV
F
LV
M
YLFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
A
I
L
A
A
F
G
Y
S
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
D
KLP
P
KE
A
TE
K
SMS
QIQ
G
AL
VGIAMV
L
S
AVFIPM
A
F
FG
G
ST
G
A
IYR
Q
FSIT
IVS
AM
AL
SV
L
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWF
N
TT
F
DHSVNH
----
Y
TNSVG
K
I
L
GSTGRY
L
L
I
Y
A
L
IVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VT
DYY
LKNEKAN
V
E
SVF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
SGDENSAE
A
V
I
H
RA
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VEL
G
TA
T
GFDFE
L
IDQAGLGH
D
A
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
L
E
VD
QE
KA
Q
A
L
GVSL
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
ML
P
ED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TAHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QG
EA
APGT
S
S
G
D
A
MALMENLASQ
L
-
-
P
A
G
IGYD
W
T
G
--
MS
YQ
ER
L
SGNQAPA
L
V
A
-
I
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLM
E
KE
----------
G
KGVV
EA
TLM
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
VS
A
T
LLAI
fig|550676.3.peg.2372
Escherichia coli B185 (17-1021/1040)
I
M
RPVA
TTL
L
----
M
V
A
I
L
L
A
G
IIG
Y
RA
LPV
S
AL
P
E
V
DY
P
T
I
Q
V
V
T
L
YPGA
S
PD
V
M
T
S
A
VT
A
PL
E
RQ
F
GQ
M
S
GL
K
Q
MSS
Q
S
SG-
G
ASV
ITL
Q
F
Q
L
TL
P
L
D
V
A
EQ
E
VQ
AA
IN
A
A
TNL
LP
SDLPNP
P
V
YSKVNPADP
---
P
I
MTL
A
VT
S
T--AMPMT
Q
V
E
D
M
V
ETR
V
AQK
I
S
QIS
GVG
L
V
TLS
G
GQRPAV
R
V
K
L
NA
QA
IA
ALG
L
TSET
V
RT
AI
TGA
N
VNSAK
G
S
L
--
-
-
--DGPSRAVT
L
S
A
NDQ
M
Q
S
A
EE
Y
RQ
L
I
I
AYQ-
N
G
AP
I
R
L
G
DVA
T
VE
Q
G
A
E
NSWLG
A
WA
N
K
E
-
Q
A
I
V
MN
V
Q
R
QP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TES
L
P
K
S
VK
VTVL
S
D
R
T
TN
I
RA
S
V
D
D
TQFE
L
M
M
AI
A
LV
V
M
I
I
YLFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
A
V
M
V
F
L
D
F
S
I
N
N
LT
L
M
A
L
T
I
A
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
K
GEK
P
LA
A
AL
K
GAG
E
I
G
F
TI
ISLTFS
L
I
AV
L
IP
L
L
F
MG
D
IV
G
R
LF
R
E
F
A
IT
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRAS
E
KM
F
DRIIAA
----
Y
GRGLA
KVL
NHPWLT
L
S
V
A
L
S
TLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VA
D
--
VILQDPA
V
Q
S
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LK
L
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQ
V
SR
T
QYQFT
L
QAT---SL
D
A
L
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
QD
KGLVAY
VNVD
RD
S
A
S
R
L
G
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
L
E
HNTEN
T
PG
L
AA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SF
N
V
PDNY
S
L
G
D
A
VQAIMDTEKT
L
N
L
P
V
D
ITTQ
F
Q
G
ST
LA
F
Q
SA
L
GS--TVW
L
I
V
-
A
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAE
R
EQ
----------
G
MSPR
D
A
IYQ
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
VV
S
Q
V
L
T
L
F
TT
P
VI
Y
L
L
fig|216592.1.peg.4196
Escherichia coli 042 (1-1018/1034)
M
ANFF
IRRP
IF
AWV
L
----
AI
I
L
M
M
A
G
VLA
I
LQ
LPV
A
QYP
T
I
AP
P
A
V
S
V
S
A
N
YPGA
D
AQ
T
V
Q
D
T
VT
Q
VIE
QN
M
NG
I
D
N
LM
Y
MSS
T
S
DSA
G
SVT
ITL
T
F
Q
S
GT
D
PD
I
A
QV
QVQ
NK
LQ
L
A
TPL
LP
QEVQQQ
G
I
SVE-KSSSS
---
Y
L
MVA
G
FV
S
DNPGTTQD
DI
S
D
Y
V
ASN
V
KDT
LS
RLN
GVG
D
V
QLF
G
AQY-AM
RI
W
LD
A
DL
LN
KYK
L
TPVD
V
IN
QL
KVQ
N
DQIAA
GQLGG
T
P
ALPGQQLNAS
I
I
A
QTR
L
K
N
P
EEF
GK
V
T
L
RVNS
DG
SV
V
R
L
K
DVA
R
VE
L
G
G
E
NYNVI
A
RI
NGK
-
P
A
A
G
LG
I
K
L
AT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPF
FP
Q
G
M
K
VLYP
YDTT
PF
V
QL
SI
H
E
VVKT
L
F
EAI
M
LV
F
LV
M
YLFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
A
I
L
A
A
F
G
Y
S
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
D
KLP
P
KE
A
TE
K
SMS
QIQ
G
AL
VGIAMV
L
S
AVFIPM
A
F
FG
G
ST
G
A
IYR
Q
FSIT
IVS
AM
AL
SV
L
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWF
N
TT
F
DHSVNH
----
Y
TNSVG
K
I
L
GSTGRY
L
L
I
Y
A
L
IVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VT
DYY
LKNEKAN
V
E
SVF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
K
-
R
NGDKNSAE
A
V
I
H
RA
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VEL
G
TA
T
GFDFE
L
IDQAGLGH
D
A
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
L
E
VD
QE
KA
Q
A
L
GVSL
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
ML
P
ED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TAHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QG
EA
APGT
S
S
G
D
A
MALMENLASQ
L
-
-
P
A
G
IGYD
W
T
G
--
MS
YQ
ER
L
SGNQAPA
L
V
A
-
I
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLM
E
KE
----------
G
KGVV
EA
TLM
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
VS
A
T
LLAI
fig|216592.3.peg.3689
Escherichia coli 042 (1-1018/1034)
M
ANFF
IRRP
IF
AWV
L
----
AI
I
L
M
M
A
G
VLA
I
LQ
LPV
A
QYP
T
I
AP
P
A
V
S
V
S
A
N
YPGA
D
AQ
T
V
Q
D
T
VT
Q
VIE
QN
M
NG
I
D
N
LM
Y
MSS
T
S
DSA
G
SVT
ITL
T
F
Q
S
GT
D
PD
I
A
QV
QVQ
NK
LQ
L
A
TPL
LP
QEVQQQ
G
I
SVE-KSSSS
---
Y
L
MVA
G
FV
S
DNPGTTQD
DI
S
D
Y
V
ASN
V
KDT
LS
RLN
GVG
D
V
QLF
G
AQY-AM
RI
W
LD
A
DL
LN
KYK
L
TPVD
V
IN
QL
KVQ
N
DQIAA
GQLGG
T
P
ALPGQQLNAS
I
I
A
QTR
L
K
N
P
EEF
GK
V
T
L
RVNS
DG
SV
V
R
L
K
DVA
R
VE
L
G
G
E
NYNVI
A
RI
NGK
-
P
A
A
G
LG
I
K
L
AT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPF
FP
Q
G
M
K
VLYP
YDTT
PF
V
QL
SI
H
E
VVKT
L
F
EAI
M
LV
F
LV
M
YLFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
A
I
L
A
A
F
G
Y
S
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
D
KLP
P
KE
A
TE
K
SMS
QIQ
G
AL
VGIAMV
L
S
AVFIPM
A
F
FG
G
ST
G
A
IYR
Q
FSIT
IVS
AM
AL
SV
L
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWF
N
TT
F
DHSVNH
----
Y
TNSVG
K
I
L
GSTGRY
L
L
I
Y
A
L
IVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VT
DYY
LKNEKAN
V
E
SVF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
K
-
R
NGDKNSAE
A
V
I
H
RA
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VEL
G
TA
T
GFDFE
L
IDQAGLGH
D
A
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
L
E
VD
QE
KA
Q
A
L
GVSL
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
ML
P
ED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TAHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QG
EA
APGT
S
S
G
D
A
MALMENLASQ
L
-
-
P
A
G
IGYD
W
T
G
--
MS
YQ
ER
L
SGNQAPA
L
V
A
-
I
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLM
E
KE
----------
G
KGVV
EA
TLM
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
VS
A
T
LLAI
fig|656379.3.peg.2607
Escherichia coli FVEC1302 (17-1021/1040)
I
M
RPVA
TTL
L
----
M
V
A
I
L
L
A
G
IIG
Y
RA
LPV
S
AL
P
E
V
DY
P
T
I
Q
V
V
T
L
YPGA
S
PD
V
M
T
S
A
VT
A
PL
E
RQ
F
GQ
M
S
GL
K
Q
MSS
Q
S
SG-
G
ASV
ITL
Q
F
Q
L
TL
P
L
D
V
A
EQ
E
VQ
AA
IN
A
A
TNL
LP
SDLPNP
P
V
YSKVNPADP
---
P
I
MTL
A
VT
S
T--AMPMT
Q
V
E
D
M
V
ETR
V
AQK
I
S
QIS
GVG
L
V
TLS
G
GQRPAV
R
V
K
L
NA
QA
IA
ALG
L
TSET
V
RT
AI
TGA
N
VNSAK
G
S
L
--
-
-
--DGPSRAVT
L
S
A
NDQ
M
Q
S
A
EE
Y
RQ
L
I
I
AYQ-
N
G
AP
I
R
L
G
DVA
T
VE
Q
G
A
E
NSWLG
A
WA
N
K
E
-
Q
A
I
V
MN
V
Q
R
QP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TES
L
P
K
S
VK
VTVL
S
D
R
T
TN
I
RA
S
V
N
D
TQFE
L
M
M
AI
A
LV
V
M
I
I
YLFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
A
V
M
V
F
L
D
F
S
I
N
N
LT
L
M
A
L
T
I
A
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
K
GEK
P
LA
A
AL
K
GAG
E
I
G
F
TI
ISLTFS
L
I
AV
L
IP
L
L
F
MG
D
IV
G
R
LF
R
E
F
A
IT
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRAS
E
KM
F
ERIIAA
----
Y
GRGLA
KVL
NHPWLT
L
S
V
A
L
S
TLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FTNMAQRQR
Q
VA
D
--
VILQDPA
V
Q
S
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQ
V
SR
T
QYQFT
L
QAT---SL
D
A
L
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
QD
KGLVAY
VNVD
RD
S
A
S
R
L
G
INM
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
L
E
HNTEN
T
PG
L
AA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SF
N
V
PDNY
S
L
G
D
A
VQAIMDTEKT
L
N
L
P
V
D
ITTQ
F
Q
G
ST
LA
F
Q
SA
L
GS--TVW
L
I
V
-
A
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAE
R
EQ
----------
G
MSPR
D
A
IYQ
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
IV
S
Q
V
L
T
L
F
TT
P
VI
Y
L
L
fig|656380.3.peg.2167
Escherichia coli FVEC1412 (17-1021/1040)
I
M
RPVA
TTL
L
----
M
V
A
I
L
L
A
G
IIG
Y
RA
LPV
S
AL
P
E
V
DY
P
T
I
Q
V
V
T
L
YPGA
S
PD
V
M
T
S
A
VT
A
PL
E
RQ
F
GQ
M
S
GL
K
Q
MSS
Q
S
SG-
G
ASV
ITL
Q
F
Q
L
TL
P
L
D
V
A
EQ
E
VQ
AA
IN
A
A
TNL
LP
SDLPNP
P
V
YSKVNPADP
---
P
I
MTL
A
VT
S
T--AMPMT
Q
V
E
D
M
V
ETR
V
AQK
I
S
QIS
GVG
L
V
TLS
G
GQRPAV
R
V
K
L
NA
QA
IA
ALG
L
TSET
V
RT
AI
TGA
N
VNSAK
G
S
L
--
-
-
--DGPSRAVT
L
S
A
NDQ
M
Q
S
A
EE
Y
RQ
L
I
I
AYQ-
N
G
AP
I
R
L
G
DVA
T
VE
Q
G
A
E
NSWLG
A
WA
N
K
E
-
Q
A
I
V
MN
V
Q
R
QP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TES
L
P
K
S
VK
VTVL
S
D
R
T
TN
I
RA
S
V
N
D
TQFE
L
M
M
AI
A
LV
V
M
I
I
YLFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
A
V
M
V
F
L
D
F
S
I
N
N
LT
L
M
A
L
T
I
A
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
K
GEK
P
LA
A
AL
K
GAG
E
I
G
F
TI
ISLTFS
L
I
AV
L
IP
L
L
F
MG
D
IV
G
R
LF
R
E
F
A
IT
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRAS
E
KM
F
ERIIAA
----
Y
GRGLA
KVL
NHPWLT
L
S
V
A
L
S
TLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FTNMAQRQR
Q
VA
D
--
VILQDPA
V
Q
S
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQ
V
SR
T
QYQFT
L
QAT---SL
D
A
L
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
QD
KGLVAY
VNVD
RD
S
A
S
R
L
G
INM
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
L
E
HNTEN
T
PG
L
AA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SF
N
V
PDNY
S
L
G
D
A
VQAIMDTEKT
L
N
L
P
V
D
ITTQ
F
Q
G
ST
LA
F
Q
SA
L
GS--TVW
L
I
V
-
A
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAE
R
EQ
----------
G
MSPR
D
A
IYQ
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
IV
S
Q
V
L
T
L
F
TT
P
VI
Y
L
L
fig|656437.3.peg.2336
Escherichia coli TA143 (17-1021/1040)
I
M
RPVA
TTL
L
----
M
V
A
I
L
L
A
G
IIG
Y
RA
LPV
S
AL
P
E
V
DY
P
T
I
Q
V
V
T
L
YPGA
S
PD
V
M
T
S
A
VT
A
PL
E
RQ
F
GQ
M
S
GL
K
Q
MSS
Q
S
SG-
G
ASV
ITL
Q
F
Q
L
TL
P
L
D
V
A
EQ
E
VQ
AA
IN
A
A
TNL
LP
SDLPNP
P
V
YSKVNPADP
---
P
I
MTL
A
VT
S
T--AMPMT
Q
V
E
D
M
V
ETR
V
AQK
I
S
QIS
GVG
L
V
TLS
G
GQRPAV
R
V
K
L
NA
QA
IA
ALG
L
TSET
V
RT
AI
TGA
N
VNSAK
G
S
L
--
-
-
--DGPSRAVT
L
S
A
NDQ
M
Q
S
A
EE
Y
RQ
L
I
I
AYQ-
N
G
AP
I
R
L
G
DVA
T
VE
Q
G
A
E
NSWLG
A
WA
N
K
E
-
Q
A
I
V
MN
V
Q
R
QP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TES
L
P
K
S
VK
VTVL
S
D
R
T
TN
I
RA
S
V
N
D
TQFE
L
M
M
AI
A
LV
V
M
I
I
YLFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
A
V
M
V
F
L
D
F
S
I
N
N
LT
L
M
A
L
T
I
A
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
K
GEK
P
LA
A
AL
K
GAG
E
I
G
F
TI
ISLTFS
L
I
AV
L
IP
L
L
F
MG
D
IV
G
R
LF
R
E
F
A
IT
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRAS
E
KM
F
ERIIAA
----
Y
GRGLA
KVL
NHPWLT
L
S
V
A
L
S
TLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FTNMAQRQR
Q
VA
D
--
VILQDPA
V
Q
S
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQ
V
SR
T
QYQFT
L
QAT---SL
D
A
L
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
QD
KGLVAY
VNVD
RD
S
A
S
R
L
G
INM
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
L
E
HNTEN
T
PG
L
AA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SF
N
V
PDNY
S
L
G
D
A
VQAIMDTEKT
L
N
L
P
V
D
ITTQ
F
Q
G
ST
LA
F
Q
SA
L
GS--TVW
L
I
V
-
A
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAE
R
EQ
----------
G
MSPR
D
A
IYQ
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
IV
S
Q
V
L
T
L
F
TT
P
VI
Y
L
L
fig|585056.7.peg.2594
Escherichia coli UMN026 (17-1021/1040)
I
M
RPVA
TTL
L
----
M
V
A
I
L
L
A
G
IIG
Y
RA
LPV
S
AL
P
E
V
DY
P
T
I
Q
V
V
T
L
YPGA
S
PD
V
M
T
S
A
VT
A
PL
E
RQ
F
GQ
M
S
GL
K
Q
MSS
Q
S
SG-
G
ASV
ITL
Q
F
Q
L
TL
P
L
D
V
A
EQ
E
VQ
AA
IN
A
A
TNL
LP
SDLPNP
P
V
YSKVNPADP
---
P
I
MTL
A
VT
S
T--AMPMT
Q
V
E
D
M
V
ETR
V
AQK
I
S
QIS
GVG
L
V
TLS
G
GQRPAV
R
V
K
L
NA
QA
IA
ALG
L
TSET
V
RT
AI
TGA
N
VNSAK
G
S
L
--
-
-
--DGPSRAVT
L
S
A
NDQ
M
Q
S
A
EE
Y
RQ
L
I
I
AYQ-
N
G
AP
I
R
L
G
DVA
T
VE
Q
G
A
E
NSWLG
A
WA
N
K
E
-
Q
A
I
V
MN
V
Q
R
QP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TES
L
P
K
S
VK
VTVL
S
D
R
T
TN
I
RA
S
V
N
D
TQFE
L
M
M
AI
A
LV
V
M
I
I
YLFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
A
V
M
V
F
L
D
F
S
I
N
N
LT
L
M
A
L
T
I
A
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
K
GEK
P
LA
A
AL
K
GAG
E
I
G
F
TI
ISLTFS
L
I
AV
L
IP
L
L
F
MG
D
IV
G
R
LF
R
E
F
A
IT
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRAS
E
KM
F
ERIIAA
----
Y
GRGLA
KVL
NHPWLT
L
S
V
A
L
S
TLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FTNMAQRQR
Q
VA
D
--
VILQDPA
V
Q
S
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQ
V
SR
T
QYQFT
L
QAT---SL
D
A
L
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
QD
KGLVAY
VNVD
RD
S
A
S
R
L
G
INM
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
L
E
HNTEN
T
PG
L
AA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SF
N
V
PDNY
S
L
G
D
A
VQAIMDTEKT
L
N
L
P
V
D
ITTQ
F
Q
G
ST
LA
F
Q
SA
L
GS--TVW
L
I
V
-
A
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAE
R
EQ
----------
G
MSPR
D
A
IYQ
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
IV
S
Q
V
L
T
L
F
TT
P
VI
Y
L
L
fig|585057.4.peg.992
Escherichia coli IAI39 (17-1021/1040)
I
M
RPVA
TTL
L
----
M
V
A
I
L
L
A
G
IIG
Y
RA
LPV
S
AL
P
E
V
DY
P
T
I
Q
V
V
T
L
YPGA
S
PD
V
M
T
S
A
VT
A
PL
E
RQ
F
GQ
M
S
GL
K
Q
MSS
Q
S
SG-
G
ASV
ITL
Q
F
Q
L
TL
P
L
D
V
A
EQ
E
VQ
AA
IN
A
A
TNL
LP
SDLPNP
P
V
YSKVNPADP
---
P
I
MTL
A
VT
S
T--AMPMT
Q
V
E
D
M
V
ETR
V
AQK
I
S
QIS
GVG
L
V
TLS
G
GQRPAV
R
V
K
L
NA
QA
IA
ALG
L
TSET
V
RT
AI
TGA
N
VNSAK
G
S
L
--
-
-
--DGPSRAVT
L
S
A
NDQ
M
Q
S
A
EE
Y
RQ
L
I
I
AYQ-
N
S
AP
I
R
L
G
DVA
T
VE
Q
G
A
E
NSWLG
A
WA
N
K
E
-
Q
A
I
V
MN
V
Q
R
QP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TES
L
P
K
S
VK
VTVL
S
D
R
T
TN
I
RA
S
V
D
D
TQFE
L
M
M
AI
A
LV
V
M
I
I
YLFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
A
V
M
V
F
L
D
F
S
I
N
N
LT
L
M
A
L
T
I
A
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
K
GEK
P
LA
A
AL
K
GAG
E
I
G
F
TI
ISLTFS
L
I
AV
L
IP
L
L
F
MG
D
IV
G
R
LF
R
E
F
A
IT
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRAS
E
KM
F
DRIIAA
----
Y
GRGLA
KVL
NHPWLT
L
S
V
A
L
S
TLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FTNMAQRQR
Q
VA
D
--
VILQDPA
V
Q
S
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQ
V
SR
T
QYQFT
L
QAT---SL
D
A
L
STWVP
QL
VEK
L
QQL
P
-Q
L
SD
V
SS
D
W
QD
KGLVAY
VNVD
RD
S
A
S
R
L
G
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
L
E
HNTEN
T
PG
L
AA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SF
N
V
PDNY
S
L
G
D
A
VQAIMDTEKT
L
N
L
P
V
D
ITTQ
F
Q
G
ST
LA
F
Q
SA
L
GS--TVW
L
I
V
-
A
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAE
R
EQ
----------
G
MSPR
D
A
IYQ
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
IV
S
Q
V
L
T
L
F
TT
P
VI
Y
L
L
fig|585057.6.peg.989
Escherichia coli IAI39 (17-1021/1040)
I
M
RPVA
TTL
L
----
M
V
A
I
L
L
A
G
IIG
Y
RA
LPV
S
AL
P
E
V
DY
P
T
I
Q
V
V
T
L
YPGA
S
PD
V
M
T
S
A
VT
A
PL
E
RQ
F
GQ
M
S
GL
K
Q
MSS
Q
S
SG-
G
ASV
ITL
Q
F
Q
L
TL
P
L
D
V
A
EQ
E
VQ
AA
IN
A
A
TNL
LP
SDLPNP
P
V
YSKVNPADP
---
P
I
MTL
A
VT
S
T--AMPMT
Q
V
E
D
M
V
ETR
V
AQK
I
S
QIS
GVG
L
V
TLS
G
GQRPAV
R
V
K
L
NA
QA
IA
ALG
L
TSET
V
RT
AI
TGA
N
VNSAK
G
S
L
--
-
-
--DGPSRAVT
L
S
A
NDQ
M
Q
S
A
EE
Y
RQ
L
I
I
AYQ-
N
S
AP
I
R
L
G
DVA
T
VE
Q
G
A
E
NSWLG
A
WA
N
K
E
-
Q
A
I
V
MN
V
Q
R
QP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TES
L
P
K
S
VK
VTVL
S
D
R
T
TN
I
RA
S
V
D
D
TQFE
L
M
M
AI
A
LV
V
M
I
I
YLFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
A
V
M
V
F
L
D
F
S
I
N
N
LT
L
M
A
L
T
I
A
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
K
GEK
P
LA
A
AL
K
GAG
E
I
G
F
TI
ISLTFS
L
I
AV
L
IP
L
L
F
MG
D
IV
G
R
LF
R
E
F
A
IT
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRAS
E
KM
F
DRIIAA
----
Y
GRGLA
KVL
NHPWLT
L
S
V
A
L
S
TLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FTNMAQRQR
Q
VA
D
--
VILQDPA
V
Q
S
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQ
V
SR
T
QYQFT
L
QAT---SL
D
A
L
STWVP
QL
VEK
L
QQL
P
-Q
L
SD
V
SS
D
W
QD
KGLVAY
VNVD
RD
S
A
S
R
L
G
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
L
E
HNTEN
T
PG
L
AA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SF
N
V
PDNY
S
L
G
D
A
VQAIMDTEKT
L
N
L
P
V
D
ITTQ
F
Q
G
ST
LA
F
Q
SA
L
GS--TVW
L
I
V
-
A
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAE
R
EQ
----------
G
MSPR
D
A
IYQ
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
IV
S
Q
V
L
T
L
F
TT
P
VI
Y
L
L
fig|358709.5.peg.4812
Escherichia coli 101-1 (1-1018/1034)
M
ANFF
IRRP
IF
AWV
L
----
AI
I
L
M
M
A
G
ALA
I
LQ
LPV
A
QYP
T
I
AP
P
A
V
S
V
S
A
N
YPGA
D
AQ
T
V
Q
D
T
VT
Q
VIE
QN
M
NG
I
D
N
LM
Y
MSS
T
S
DSA
G
SVT
ITL
T
F
Q
S
GT
D
PD
I
A
QV
QVQ
NK
LQ
L
A
TPL
LP
QEVQQQ
G
I
SVE-KSSSS
---
Y
L
MVA
G
FV
S
DNPDTTQD
DI
S
D
Y
V
ASN
V
KDT
LS
RLN
GVG
D
V
QLF
G
AQY-AM
RI
W
LD
A
DL
LN
KYK
L
TPVD
V
IN
QL
KVQ
N
DQIAA
GQLGG
T
P
ALPGQQLNAS
I
I
A
QTR
L
K
N
P
EEF
GK
V
T
L
RVNS
DG
SV
V
R
L
K
DVA
R
VE
L
G
G
E
NYNVI
A
RI
NGK
-
P
A
A
G
LG
I
K
L
AT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPF
FP
Q
G
M
K
VLYP
YDTT
PF
V
QL
SI
H
E
VVKT
L
F
EAI
M
LV
F
LV
M
YLFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
A
I
L
A
A
F
G
Y
S
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
D
KLP
P
KE
A
TE
K
SMS
QIQ
G
AL
VGIAMV
L
S
AVFIPM
A
F
FG
G
ST
G
A
IYR
Q
FSIT
IVS
AM
AL
SV
L
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWF
N
TT
F
DHSVNH
----
Y
TNSVG
K
I
L
GSTGRY
L
L
I
Y
A
L
IVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VT
DYY
LKNEKAN
V
E
SVF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
NGDENSAE
A
V
I
H
RA
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VEL
G
TA
T
GFDFE
L
IDQAGLGH
D
A
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
L
E
VD
QE
KA
Q
A
L
GVSL
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
ML
P
ED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QG
EA
APGT
S
S
G
D
A
MALMENLASK
L
-
-
P
A
G
IGYD
W
T
G
--
MS
YQ
ER
L
SGNQAPA
L
V
A
-
I
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLM
E
KE
----------
G
KGVV
EA
TLM
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
VS
A
T
LLAI
fig|670888.3.peg.2982
Escherichia coli 1827-70 (1-1018/1034)
M
ANFF
IRRP
IF
AWV
L
----
AI
I
L
M
M
A
G
ALA
I
LQ
LPV
A
QYP
T
I
AP
P
A
V
S
V
S
A
N
YPGA
D
AQ
T
V
Q
D
T
VT
Q
VIE
QN
M
NG
I
D
N
LM
Y
MSS
T
S
DSA
G
SVT
ITL
T
F
Q
S
GT
D
PD
I
A
QV
QVQ
NK
LQ
L
A
TPL
LP
QEVQQQ
G
I
SVE-KSSSS
---
Y
L
MVA
G
FV
S
DNPDTTQD
DI
S
D
Y
V
ASN
V
KDT
LS
RLN
GVG
D
V
QLF
G
AQY-AM
RI
W
LD
A
DL
LN
KYK
L
TPVD
V
IN
QL
KVQ
N
DQIAA
GQLGG
T
P
ALPGQQLNAS
I
I
A
QTR
L
K
N
P
EEF
GK
V
T
L
RVNS
DG
SV
V
R
L
K
DVA
R
VE
L
G
G
E
NYNVI
A
RI
NGK
-
P
A
A
G
LG
I
K
L
AT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPF
FP
Q
G
M
K
VLYP
YDTT
PF
V
QL
SI
H
E
VVKT
L
F
EAI
M
LV
F
LV
M
YLFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
A
I
L
A
A
F
G
Y
S
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
D
KLP
P
KE
A
TE
K
SMS
QIQ
G
AL
VGIAMV
L
S
AVFIPM
A
F
FG
G
ST
G
A
IYR
Q
FSIT
IVS
AM
AL
SV
L
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWF
N
TT
F
DHSVNH
----
Y
TNSVG
K
I
L
GSTGRY
L
L
I
Y
A
L
IVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VT
DYY
LKNEKAN
V
E
SVF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
NGDENSAE
A
V
I
H
RA
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VEL
G
TA
T
GFDFE
L
IDQAGLGH
D
A
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
L
E
VD
QE
KA
Q
A
L
GVSL
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
ML
P
ED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QG
EA
APGT
S
S
G
D
A
MALMENLASK
L
-
-
P
A
G
IGYD
W
T
G
--
MS
YQ
ER
L
SGNQAPA
L
V
A
-
I
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLM
E
KE
----------
G
KGVV
EA
TLM
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
VS
A
T
LLAI
fig|331112.3.peg.3237
Escherichia coli HS (1-1018/1034)
M
ANFF
IRRP
IF
AWV
L
----
AI
I
L
M
M
A
G
ALA
I
LQ
LPV
A
QYP
T
I
AP
P
A
V
S
V
S
A
N
YPGA
D
AQ
T
V
Q
D
T
VT
Q
VIE
QN
M
NG
I
D
N
LM
Y
MSS
T
S
DSA
G
SVT
ITL
T
F
Q
S
GT
D
PD
I
A
QV
QVQ
NK
LQ
L
A
TPL
LP
QEVQQQ
G
I
SVE-KSSSS
---
Y
L
MVA
G
FV
S
DNPDTTQD
DI
S
D
Y
V
ASN
V
KDT
LS
RLN
GVG
D
V
QLF
G
AQY-AM
RI
W
LD
A
DL
LN
KYK
L
TPVD
V
IN
QL
KVQ
N
DQIAA
GQLGG
T
P
ALPGQQLNAS
I
I
A
QTR
L
K
N
P
EEF
GK
V
T
L
RVNS
DG
SV
V
R
L
K
DVA
R
VE
L
G
G
E
NYNVI
A
RI
NGK
-
P
A
A
G
LG
I
K
L
AT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPF
FP
Q
G
M
K
VLYP
YDTT
PF
V
QL
SI
H
E
VVKT
L
F
EAI
M
LV
F
LV
M
YLFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
A
I
L
A
A
F
G
Y
S
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
D
KLP
P
KE
A
TE
K
SMS
QIQ
G
AL
VGIAMV
L
S
AVFIPM
A
F
FG
G
ST
G
A
IYR
Q
FSIT
IVS
AM
AL
SV
L
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWF
N
TT
F
DHSVNH
----
Y
TNSVG
K
I
L
GSTGRY
L
L
I
Y
A
L
IVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VT
DYY
LKNEKAN
V
E
SVF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
NGDENSAE
A
V
I
H
RA
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VEL
G
TA
T
GFDFE
L
IDQAGLGH
D
A
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
L
E
VD
QE
KA
Q
A
L
GVSL
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
ML
P
ED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QG
EA
APGT
S
S
G
D
A
MALMENLASK
L
-
-
P
A
G
IGYD
W
T
G
--
MS
YQ
ER
L
SGNQAPA
L
V
A
-
I
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLM
E
KE
----------
G
KGVV
EA
TLM
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
VS
A
T
LLAI
fig|331112.6.peg.3374
Escherichia coli HS (1-1018/1034)
M
ANFF
IRRP
IF
AWV
L
----
AI
I
L
M
M
A
G
ALA
I
LQ
LPV
A
QYP
T
I
AP
P
A
V
S
V
S
A
N
YPGA
D
AQ
T
V
Q
D
T
VT
Q
VIE
QN
M
NG
I
D
N
LM
Y
MSS
T
S
DSA
G
SVT
ITL
T
F
Q
S
GT
D
PD
I
A
QV
QVQ
NK
LQ
L
A
TPL
LP
QEVQQQ
G
I
SVE-KSSSS
---
Y
L
MVA
G
FV
S
DNPDTTQD
DI
S
D
Y
V
ASN
V
KDT
LS
RLN
GVG
D
V
QLF
G
AQY-AM
RI
W
LD
A
DL
LN
KYK
L
TPVD
V
IN
QL
KVQ
N
DQIAA
GQLGG
T
P
ALPGQQLNAS
I
I
A
QTR
L
K
N
P
EEF
GK
V
T
L
RVNS
DG
SV
V
R
L
K
DVA
R
VE
L
G
G
E
NYNVI
A
RI
NGK
-
P
A
A
G
LG
I
K
L
AT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPF
FP
Q
G
M
K
VLYP
YDTT
PF
V
QL
SI
H
E
VVKT
L
F
EAI
M
LV
F
LV
M
YLFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
A
I
L
A
A
F
G
Y
S
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
D
KLP
P
KE
A
TE
K
SMS
QIQ
G
AL
VGIAMV
L
S
AVFIPM
A
F
FG
G
ST
G
A
IYR
Q
FSIT
IVS
AM
AL
SV
L
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWF
N
TT
F
DHSVNH
----
Y
TNSVG
K
I
L
GSTGRY
L
L
I
Y
A
L
IVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VT
DYY
LKNEKAN
V
E
SVF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
NGDENSAE
A
V
I
H
RA
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VEL
G
TA
T
GFDFE
L
IDQAGLGH
D
A
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
L
E
VD
QE
KA
Q
A
L
GVSL
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
ML
P
ED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QG
EA
APGT
S
S
G
D
A
MALMENLASK
L
-
-
P
A
G
IGYD
W
T
G
--
MS
YQ
ER
L
SGNQAPA
L
V
A
-
I
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLM
E
KE
----------
G
KGVV
EA
TLM
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
VS
A
T
LLAI
fig|562.375.peg.2295
Escherichia coli EC4100B (17-1021/1040)
I
M
RPVA
TTL
L
----
M
V
A
I
L
L
A
G
IIG
Y
RA
LPV
S
AL
P
E
V
DY
P
T
I
Q
V
V
T
L
YPGA
S
PD
V
M
T
S
A
VT
A
PL
E
RQ
F
GQ
M
S
GL
K
Q
MSS
Q
S
SG-
G
ASV
ITL
Q
F
Q
L
TL
P
L
D
V
A
EQ
E
VQ
AA
IN
A
A
TNL
LP
SDLPNP
P
V
YSKVNPADP
---
P
I
MTL
A
VT
S
T--AMPMT
Q
V
E
D
M
V
ETR
V
AQK
I
S
QIS
GVG
L
V
TLS
G
GQRPAV
R
V
K
L
NA
QA
IA
ALG
L
TSET
V
RT
AI
TGA
N
VNSAK
G
S
L
--
-
-
--DGPSRAVT
L
S
A
NDQ
M
Q
S
A
EE
Y
RQ
L
I
I
AYQ-
N
G
AP
I
R
L
G
DVA
T
VE
Q
G
A
E
NSWLG
A
WA
N
K
E
-
Q
A
I
V
MN
V
Q
R
QP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TES
L
P
K
S
VK
VTVL
S
D
R
T
TN
I
RA
S
V
N
D
TQFE
L
M
M
AI
A
LV
V
M
I
I
YLFL
R
N
I
P
AT
I
IP
G
F
AVP
L
S
L
I
GTF
A
V
M
V
F
L
D
F
S
I
N
N
LT
L
M
A
L
T
I
A
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
K
GEK
P
LA
A
AL
K
GAG
E
I
G
F
TI
ISLTFS
L
I
AV
L
IP
L
L
F
MG
D
IV
G
R
LF
R
E
F
A
IT
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRAS
E
KM
F
DRIIAA
----
Y
GRGLA
KVL
NHPWLT
L
S
V
A
L
S
TLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VA
D
--
VILQDPA
V
Q
S
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQ
V
SR
T
QYQFT
L
QAT---SL
D
A
L
STWVP
E
L
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
QD
KGLVAY
VNVD
RD
S
A
S
R
L
G
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
L
E
HNTEN
T
PG
L
AA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SF
N
V
PDNY
S
L
G
D
A
VQAIMDTEKT
L
N
L
P
V
D
ITTQ
F
Q
G
ST
LA
F
Q
SA
L
GS--TVW
L
I
V
-
A
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAE
R
EQ
----------
G
MSPR
D
A
IYQ
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
IV
S
Q
V
L
T
L
F
TT
P
VI
Y
L
L
fig|656414.3.peg.2434
Escherichia coli H736 (17-1021/1040)
I
M
RPVA
TTL
L
----
M
V
A
I
L
L
A
G
IIG
Y
RA
LPV
S
AL
P
E
V
DY
P
T
I
Q
V
V
T
L
YPGA
S
PD
V
M
T
S
A
VT
A
PL
E
RQ
F
GQ
M
S
GL
K
Q
MSS
Q
S
SG-
G
ASV
ITL
Q
F
Q
L
TL
P
L
D
V
A
EQ
E
VQ
AA
IN
A
A
TNL
LP
SDLPNP
P
V
YSKVNPADP
---
P
I
MTL
A
VT
S
T--AMPMT
Q
V
E
D
M
V
ETR
V
AQK
I
S
QIS
GVG
L
V
TLS
G
GQRPAV
R
V
K
L
NA
QA
IA
ALG
L
TSET
V
RT
AI
TGA
N
VNSAK
G
S
L
--
-
-
--DGPSRAVT
L
S
A
NDQ
M
Q
S
A
EE
Y
RQ
L
I
I
AYQ-
N
G
AP
I
R
L
G
DVA
T
VE
Q
G
A
E
NSWLG
A
WA
N
K
E
-
Q
A
I
V
MN
V
Q
R
QP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TES
L
P
K
S
VK
VTVL
S
D
R
T
TN
I
RA
S
V
N
D
TQFE
L
M
M
AI
A
LV
V
M
I
I
YLFL
R
N
I
P
AT
I
IP
G
F
AVP
L
S
L
I
GTF
A
V
M
V
F
L
D
F
S
I
N
N
LT
L
M
A
L
T
I
A
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
K
GEK
P
LA
A
AL
K
GAG
E
I
G
F
TI
ISLTFS
L
I
AV
L
IP
L
L
F
MG
D
IV
G
R
LF
R
E
F
A
IT
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRAS
E
KM
F
DRIIAA
----
Y
GRGLA
KVL
NHPWLT
L
S
V
A
L
S
TLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VA
D
--
VILQDPA
V
Q
S
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQ
V
SR
T
QYQFT
L
QAT---SL
D
A
L
STWVP
E
L
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
QD
KGLVAY
VNVD
RD
S
A
S
R
L
G
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
L
E
HNTEN
T
PG
L
AA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SF
N
V
PDNY
S
L
G
D
A
VQAIMDTEKT
L
N
L
P
V
D
ITTQ
F
Q
G
ST
LA
F
Q
SA
L
GS--TVW
L
I
V
-
A
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAE
R
EQ
----------
G
MSPR
D
A
IYQ
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
IV
S
Q
V
L
T
L
F
TT
P
VI
Y
L
L
fig|585034.4.peg.2126
Escherichia coli IAI1 (17-1021/1040)
I
M
RPVA
TTL
L
----
M
V
A
I
L
L
A
G
IIG
Y
RA
LPV
S
AL
P
E
V
DY
P
T
I
Q
V
V
T
L
YPGA
S
PD
V
M
T
S
A
VT
A
PL
E
RQ
F
GQ
M
S
GL
K
Q
MSS
Q
S
SG-
G
ASV
ITL
Q
F
Q
L
TL
P
L
D
V
A
EQ
E
VQ
AA
IN
A
A
TNL
LP
SDLPNP
P
V
YSKVNPADP
---
P
I
MTL
A
VT
S
T--AMPMT
Q
V
E
D
M
V
ETR
V
AQK
I
S
QIS
GVG
L
V
TLS
G
GQRPAV
R
V
K
L
NA
QA
IA
ALG
L
TSET
V
RT
AI
TGA
N
VNSAK
G
S
L
--
-
-
--DGPSRAVT
L
S
A
NDQ
M
Q
S
A
EE
Y
RQ
L
I
I
AYQ-
N
G
AP
I
R
L
G
DVA
T
VE
Q
G
A
E
NSWLG
A
WA
N
K
E
-
Q
A
I
V
MN
V
Q
R
QP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TES
L
P
K
S
VK
VTVL
S
D
R
T
TN
I
RA
S
V
N
D
TQFE
L
M
M
AI
A
LV
V
M
I
I
YLFL
R
N
I
P
AT
I
IP
G
F
AVP
L
S
L
I
GTF
A
V
M
V
F
L
D
F
S
I
N
N
LT
L
M
A
L
T
I
A
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
K
GEK
P
LA
A
AL
K
GAG
E
I
G
F
TI
ISLTFS
L
I
AV
L
IP
L
L
F
MG
D
IV
G
R
LF
R
E
F
A
IT
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRAS
E
KM
F
DRIIAA
----
Y
GRGLA
KVL
NHPWLT
L
S
V
A
L
S
TLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VA
D
--
VILQDPA
V
Q
S
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQ
V
SR
T
QYQFT
L
QAT---SL
D
A
L
STWVP
E
L
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
QD
KGLVAY
VNVD
RD
S
A
S
R
L
G
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
L
E
HNTEN
T
PG
L
AA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SF
N
V
PDNY
S
L
G
D
A
VQAIMDTEKT
L
N
L
P
V
D
ITTQ
F
Q
G
ST
LA
F
Q
SA
L
GS--TVW
L
I
V
-
A
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAE
R
EQ
----------
G
MSPR
D
A
IYQ
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
IV
S
Q
V
L
T
L
F
TT
P
VI
Y
L
L
fig|585034.5.peg.2121
Escherichia coli IAI1 (17-1021/1040)
I
M
RPVA
TTL
L
----
M
V
A
I
L
L
A
G
IIG
Y
RA
LPV
S
AL
P
E
V
DY
P
T
I
Q
V
V
T
L
YPGA
S
PD
V
M
T
S
A
VT
A
PL
E
RQ
F
GQ
M
S
GL
K
Q
MSS
Q
S
SG-
G
ASV
ITL
Q
F
Q
L
TL
P
L
D
V
A
EQ
E
VQ
AA
IN
A
A
TNL
LP
SDLPNP
P
V
YSKVNPADP
---
P
I
MTL
A
VT
S
T--AMPMT
Q
V
E
D
M
V
ETR
V
AQK
I
S
QIS
GVG
L
V
TLS
G
GQRPAV
R
V
K
L
NA
QA
IA
ALG
L
TSET
V
RT
AI
TGA
N
VNSAK
G
S
L
--
-
-
--DGPSRAVT
L
S
A
NDQ
M
Q
S
A
EE
Y
RQ
L
I
I
AYQ-
N
G
AP
I
R
L
G
DVA
T
VE
Q
G
A
E
NSWLG
A
WA
N
K
E
-
Q
A
I
V
MN
V
Q
R
QP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TES
L
P
K
S
VK
VTVL
S
D
R
T
TN
I
RA
S
V
N
D
TQFE
L
M
M
AI
A
LV
V
M
I
I
YLFL
R
N
I
P
AT
I
IP
G
F
AVP
L
S
L
I
GTF
A
V
M
V
F
L
D
F
S
I
N
N
LT
L
M
A
L
T
I
A
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
K
GEK
P
LA
A
AL
K
GAG
E
I
G
F
TI
ISLTFS
L
I
AV
L
IP
L
L
F
MG
D
IV
G
R
LF
R
E
F
A
IT
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRAS
E
KM
F
DRIIAA
----
Y
GRGLA
KVL
NHPWLT
L
S
V
A
L
S
TLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VA
D
--
VILQDPA
V
Q
S
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQ
V
SR
T
QYQFT
L
QAT---SL
D
A
L
STWVP
E
L
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
QD
KGLVAY
VNVD
RD
S
A
S
R
L
G
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
L
E
HNTEN
T
PG
L
AA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SF
N
V
PDNY
S
L
G
D
A
VQAIMDTEKT
L
N
L
P
V
D
ITTQ
F
Q
G
ST
LA
F
Q
SA
L
GS--TVW
L
I
V
-
A
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAE
R
EQ
----------
G
MSPR
D
A
IYQ
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
IV
S
Q
V
L
T
L
F
TT
P
VI
Y
L
L
fig|679207.4.peg.3868
Escherichia coli MS 107-1 (17-1021/1040)
I
M
RPVA
TTL
L
----
M
V
A
I
L
L
A
G
IIG
Y
RA
LPV
S
AL
P
E
V
DY
P
T
I
Q
V
V
T
L
YPGA
S
PD
V
M
T
S
A
VT
A
PL
E
RQ
F
GQ
M
S
GL
K
Q
MSS
Q
S
SG-
G
ASV
ITL
Q
F
Q
L
TL
P
L
D
V
A
EQ
E
VQ
AA
IN
A
A
TNL
LP
SDLPNP
P
V
YSKVNPADP
---
P
I
MTL
A
VT
S
T--AMPMT
Q
V
E
D
M
V
ETR
V
AQK
I
S
QIS
GVG
L
V
TLS
G
GQRPAV
R
V
K
L
NA
QA
IA
ALG
L
TSET
V
RT
AI
TGA
N
VNSAK
G
S
L
--
-
-
--DGPSRAVT
L
S
A
NDQ
M
Q
S
A
EE
Y
RQ
L
I
I
AYQ-
N
G
AP
I
R
L
G
DVA
T
VE
Q
G
A
E
NSWLG
A
WA
N
K
E
-
Q
A
I
V
MN
V
Q
R
QP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TES
L
P
K
S
VK
VTVL
S
D
R
T
TN
I
RA
S
V
N
D
TQFE
L
M
M
AI
A
LV
V
M
I
I
YLFL
R
N
I
P
AT
I
IP
G
F
AVP
L
S
L
I
GTF
A
V
M
V
F
L
D
F
S
I
N
N
LT
L
M
A
L
T
I
A
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
K
GEK
P
LA
A
AL
K
GAG
E
I
G
F
TI
ISLTFS
L
I
AV
L
IP
L
L
F
MG
D
IV
G
R
LF
R
E
F
A
IT
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRAS
E
KM
F
DRIIAA
----
Y
GRGLA
KVL
NHPWLT
L
S
V
A
L
S
TLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VA
D
--
VILQDPA
V
Q
S
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQ
V
SR
T
QYQFT
L
QAT---SL
D
A
L
STWVP
E
L
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
QD
KGLVAY
VNVD
RD
S
A
S
R
L
G
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
L
E
HNTEN
T
PG
L
AA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SF
N
V
PDNY
S
L
G
D
A
VQAIMDTEKT
L
N
L
P
V
D
ITTQ
F
Q
G
ST
LA
F
Q
SA
L
GS--TVW
L
I
V
-
A
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAE
R
EQ
----------
G
MSPR
D
A
IYQ
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
IV
S
Q
V
L
T
L
F
TT
P
VI
Y
L
L
fig|679206.4.peg.1593
Escherichia coli MS 119-7 (17-1021/1040)
I
M
RPVA
TTL
L
----
M
V
A
I
L
L
A
G
IIG
Y
RA
LPV
S
AL
P
E
V
DY
P
T
I
Q
V
V
T
L
YPGA
S
PD
V
M
T
S
A
VT
A
PL
E
RQ
F
GQ
M
S
GL
K
Q
MSS
Q
S
SG-
G
ASV
ITL
Q
F
Q
L
TL
P
L
D
V
A
EQ
E
VQ
AA
IN
A
A
TNL
LP
SDLPNP
P
V
YSKVNPADP
---
P
I
MTL
A
VT
S
T--AMPMT
Q
V
E
D
M
V
ETR
V
AQK
I
S
QIS
GVG
L
V
TLS
G
GQRPAV
R
V
K
L
NA
QA
IA
ALG
L
TSET
V
RT
AI
TGA
N
VNSAK
G
S
L
--
-
-
--DGPSRAVT
L
S
A
NDQ
M
Q
S
A
EE
Y
RQ
L
I
I
AYQ-
N
G
AP
I
R
L
G
DVA
T
VE
Q
G
A
E
NSWLG
A
WA
N
K
E
-
Q
A
I
V
MN
V
Q
R
QP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TES
L
P
K
S
VK
VTVL
S
D
R
T
TN
I
RA
S
V
N
D
TQFE
L
M
M
AI
A
LV
V
M
I
I
YLFL
R
N
I
P
AT
I
IP
G
F
AVP
L
S
L
I
GTF
A
V
M
V
F
L
D
F
S
I
N
N
LT
L
M
A
L
T
I
A
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
K
GEK
P
LA
A
AL
K
GAG
E
I
G
F
TI
ISLTFS
L
I
AV
L
IP
L
L
F
MG
D
IV
G
R
LF
R
E
F
A
IT
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRAS
E
KM
F
DRIIAA
----
Y
GRGLA
KVL
NHPWLT
L
S
V
A
L
S
TLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VA
D
--
VILQDPA
V
Q
S
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQ
V
SR
T
QYQFT
L
QAT---SL
D
A
L
STWVP
E
L
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
QD
KGLVAY
VNVD
RD
S
A
S
R
L
G
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
L
E
HNTEN
T
PG
L
AA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SF
N
V
PDNY
S
L
G
D
A
VQAIMDTEKT
L
N
L
P
V
D
ITTQ
F
Q
G
ST
LA
F
Q
SA
L
GS--TVW
L
I
V
-
A
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAE
R
EQ
----------
G
MSPR
D
A
IYQ
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
IV
S
Q
V
L
T
L
F
TT
P
VI
Y
L
L
fig|679204.3.peg.105
Escherichia coli MS 145-7 (17-1021/1040)
I
M
RPVA
TTL
L
----
M
V
A
I
L
L
A
G
IIG
Y
RA
LPV
S
AL
P
E
V
DY
P
T
I
Q
V
V
T
L
YPGA
S
PD
V
M
T
S
A
VT
A
PL
E
RQ
F
GQ
M
S
GL
K
Q
MSS
Q
S
SG-
G
ASV
ITL
Q
F
Q
L
TL
P
L
D
V
A
EQ
E
VQ
AA
IN
A
A
TNL
LP
SDLPNP
P
V
YSKVNPADP
---
P
I
MTL
A
VT
S
T--AMPMT
Q
V
E
D
M
V
ETR
V
AQK
I
S
QIS
GVG
L
V
TLS
G
GQRPAV
R
V
K
L
NA
QA
IA
ALG
L
TSET
V
RT
AI
TGA
N
VNSAK
G
S
L
--
-
-
--DGPSRAVT
L
S
A
NDQ
M
Q
S
A
EE
Y
RQ
L
I
I
AYQ-
N
G
AP
I
R
L
G
DVA
T
VE
Q
G
A
E
NSWLG
A
WA
N
K
E
-
Q
A
I
V
MN
V
Q
R
QP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TES
L
P
K
S
VK
VTVL
S
D
R
T
TN
I
RA
S
V
N
D
TQFE
L
M
M
AI
A
LV
V
M
I
I
YLFL
R
N
I
P
AT
I
IP
G
F
AVP
L
S
L
I
GTF
A
V
M
V
F
L
D
F
S
I
N
N
LT
L
M
A
L
T
I
A
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
K
GEK
P
LA
A
AL
K
GAG
E
I
G
F
TI
ISLTFS
L
I
AV
L
IP
L
L
F
MG
D
IV
G
R
LF
R
E
F
A
IT
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRAS
E
KM
F
DRIIAA
----
Y
GRGLA
KVL
NHPWLT
L
S
V
A
L
S
TLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VA
D
--
VILQDPA
V
Q
S
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQ
V
SR
T
QYQFT
L
QAT---SL
D
A
L
STWVP
E
L
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
QD
KGLVAY
VNVD
RD
S
A
S
R
L
G
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
L
E
HNTEN
T
PG
L
AA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SF
N
V
PDNY
S
L
G
D
A
VQAIMDTEKT
L
N
L
P
V
D
ITTQ
F
Q
G
ST
LA
F
Q
SA
L
GS--TVW
L
I
V
-
A
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAE
R
EQ
----------
G
MSPR
D
A
IYQ
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
IV
S
Q
V
L
T
L
F
TT
P
VI
Y
L
L
fig|749544.3.peg.957
Escherichia coli MS 175-1 (17-1021/1040)
I
M
RPVA
TTL
L
----
M
V
A
I
L
L
A
G
IIG
Y
RA
LPV
S
AL
P
E
V
DY
P
T
I
Q
V
V
T
L
YPGA
S
PD
V
M
T
S
A
VT
A
PL
E
RQ
F
GQ
M
S
GL
K
Q
MSS
Q
S
SG-
G
ASV
ITL
Q
F
Q
L
TL
P
L
D
V
A
EQ
E
VQ
AA
IN
A
A
TNL
LP
SDLPNP
P
V
YSKVNPADP
---
P
I
MTL
A
VT
S
T--AMPMT
Q
V
E
D
M
V
ETR
V
AQK
I
S
QIS
GVG
L
V
TLS
G
GQRPAV
R
V
K
L
NA
QA
IA
ALG
L
TSET
V
RT
AI
TGA
N
VNSAK
G
S
L
--
-
-
--DGPSRAVT
L
S
A
NDQ
M
Q
S
A
EE
Y
RQ
L
I
I
AYQ-
N
G
AP
I
R
L
G
DVA
T
VE
Q
G
A
E
NSWLG
A
WA
N
K
E
-
Q
A
I
V
MN
V
Q
R
QP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TES
L
P
K
S
VK
VTVL
S
D
R
T
TN
I
RA
S
V
N
D
TQFE
L
M
M
AI
A
LV
V
M
I
I
YLFL
R
N
I
P
AT
I
IP
G
F
AVP
L
S
L
I
GTF
A
V
M
V
F
L
D
F
S
I
N
N
LT
L
M
A
L
T
I
A
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
K
GEK
P
LA
A
AL
K
GAG
E
I
G
F
TI
ISLTFS
L
I
AV
L
IP
L
L
F
MG
D
IV
G
R
LF
R
E
F
A
IT
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRAS
E
KM
F
DRIIAA
----
Y
GRGLA
KVL
NHPWLT
L
S
V
A
L
S
TLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VA
D
--
VILQDPA
V
Q
S
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQ
V
SR
T
QYQFT
L
QAT---SL
D
A
L
STWVP
E
L
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
QD
KGLVAY
VNVD
RD
S
A
S
R
L
G
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
L
E
HNTEN
T
PG
L
AA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SF
N
V
PDNY
S
L
G
D
A
VQAIMDTEKT
L
N
L
P
V
D
ITTQ
F
Q
G
ST
LA
F
Q
SA
L
GS--TVW
L
I
V
-
A
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAE
R
EQ
----------
G
MSPR
D
A
IYQ
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
IV
S
Q
V
L
T
L
F
TT
P
VI
Y
L
L
fig|656443.3.peg.2773
Escherichia coli TA271 (17-1021/1040)
I
M
RPVA
TTL
L
----
M
V
A
I
L
L
A
G
IIG
Y
RA
LPV
S
AL
P
E
V
DY
P
T
I
Q
V
V
T
L
YPGA
S
PD
V
M
T
S
A
VT
A
PL
E
RQ
F
GQ
M
S
GL
K
Q
MSS
Q
S
SG-
G
ASV
ITL
Q
F
Q
L
TL
P
L
D
V
A
EQ
E
VQ
AA
IN
A
A
TNL
LP
SDLPNP
P
V
YSKVNPADP
---
P
I
MTL
A
VT
S
T--AMPMT
Q
V
E
D
M
V
ETR
V
AQK
I
S
QIS
GVG
L
V
TLS
G
GQRPAV
R
V
K
L
NA
QA
IA
ALG
L
TSET
V
RT
AI
TGA
N
VNSAK
G
S
L
--
-
-
--DGPSRAVT
L
S
A
NDQ
M
Q
S
A
EE
Y
RQ
L
I
I
AYQ-
N
G
AP
I
R
L
G
DVA
T
VE
Q
G
A
E
NSWLG
A
WA
N
K
E
-
Q
A
I
V
MN
V
Q
R
QP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TES
L
P
K
S
VK
VTVL
S
D
R
T
TN
I
RA
S
V
N
D
TQFE
L
M
M
AI
A
LV
V
M
I
I
YLFL
R
N
I
P
AT
I
IP
G
F
AVP
L
S
L
I
GTF
A
V
M
V
F
L
D
F
S
I
N
N
LT
L
M
A
L
T
I
A
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
K
GEK
P
LA
A
AL
K
GAG
E
I
G
F
TI
ISLTFS
L
I
AV
L
IP
L
L
F
MG
D
IV
G
R
LF
R
E
F
A
IT
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRAS
E
KM
F
DRIIAA
----
Y
GRGLA
KVL
NHPWLT
L
S
V
A
L
S
TLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VA
D
--
VILQDPA
V
Q
S
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQ
V
SR
T
QYQFT
L
QAT---SL
D
A
L
STWVP
E
L
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
QD
KGLVAY
VNVD
RD
S
A
S
R
L
G
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
L
E
HNTEN
T
PG
L
AA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SF
N
V
PDNY
S
L
G
D
A
VQAIMDTEKT
L
N
L
P
V
D
ITTQ
F
Q
G
ST
LA
F
Q
SA
L
GS--TVW
L
I
V
-
A
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAE
R
EQ
----------
G
MSPR
D
A
IYQ
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
IV
S
Q
V
L
T
L
F
TT
P
VI
Y
L
L
fig|585056.7.peg.3922
Escherichia coli UMN026 (1-1005/1021)
M
L
----
AI
I
L
M
M
A
G
ALA
I
LQ
LPV
A
QYP
T
I
AP
P
A
V
S
V
S
A
N
YPGA
D
AQ
T
V
Q
D
T
VT
Q
VIE
QN
M
NG
I
D
N
LM
Y
MSS
T
S
DSA
G
SVT
ITL
T
F
Q
S
GT
D
PD
I
A
QV
QVQ
NK
LQ
L
A
TPL
LP
QEVQQQ
G
I
SVE-KSSSS
---
Y
L
MVA
G
FV
S
DNPDTTQD
DI
S
D
Y
V
ASN
V
KDT
LS
RLN
GVG
D
V
QLF
G
AQY-AM
RI
W
LD
A
DL
LN
KYK
L
TPVD
V
IN
QL
KVQ
N
DQIAA
GQLGG
T
P
ALPGQQLNAS
I
I
A
QTR
L
K
N
P
EEF
GK
V
T
L
RVNS
DG
SV
V
R
L
K
DVA
R
VE
L
G
G
E
NYNVI
A
RI
NGK
-
P
A
A
G
LG
I
K
L
AT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPF
FP
Q
G
M
K
VLYP
YDTT
PF
V
QL
SI
H
E
VVKT
L
F
EAI
M
LV
F
LV
M
YLFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
A
I
L
A
A
F
G
Y
S
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
D
KLP
P
KE
A
TE
K
SMS
QIQ
G
AL
VGIAMV
L
S
AVFIPM
A
F
FG
G
ST
G
A
IYR
Q
FSIT
IVS
AM
AL
SV
L
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWF
N
TT
F
DHSVNH
----
Y
TNSVG
K
I
L
GSTGRY
L
L
I
Y
A
L
IVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VT
DYY
LKNEKAN
V
E
SVF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
SGDENSAE
A
V
I
H
RA
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VEL
G
TA
T
GFDFE
L
IDQAGLGH
D
A
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
L
E
VD
QE
KA
Q
A
L
GVSL
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
ML
P
ED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TAHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QG
EA
APGT
S
S
G
D
A
MALMENLASQ
L
-
-
P
A
G
IGYD
W
T
G
--
MS
YQ
ER
L
SGNQAPA
L
V
A
-
I
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLM
E
KE
----------
G
KGVV
EA
TLM
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
VS
A
T
LLAI
fig|550676.3.peg.3416
Escherichia coli B185 (1-1005/1021)
M
L
----
AI
I
L
M
M
A
G
ALA
I
LQ
LPV
A
QYP
T
I
AP
P
A
V
S
V
S
A
N
YPGA
D
AQ
T
V
Q
D
T
VT
Q
VIE
QN
M
NG
I
D
N
LM
Y
MSS
T
S
DSA
G
SVT
ITL
T
F
Q
S
GT
D
PD
I
A
QV
QVQ
NK
LQ
L
A
TPL
LP
QEVQQQ
G
I
SVE-KSSSS
---
Y
L
MVA
G
FV
S
DNPDTTQD
DI
S
D
Y
V
ASN
V
KDT
LS
RLN
GVG
D
V
QLF
G
AQY-AM
RI
W
LD
A
DL
LN
KYK
L
TPVD
V
IN
QL
KVQ
N
DQIAA
GQLGG
T
P
ALPGQQLNAS
I
I
A
QTR
L
K
N
P
EEF
GK
V
T
L
RVNS
DG
SV
V
R
L
K
DVA
R
VE
L
G
G
E
NYNVI
A
RI
NGK
-
P
A
A
G
LG
I
K
L
AT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPF
FP
Q
G
M
K
VLYP
YDTT
PF
V
QL
SI
H
E
VVKT
L
F
EAI
M
LV
F
LV
M
YLFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
A
I
L
A
A
F
G
Y
S
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
D
KLP
P
KE
A
TE
K
SMS
QIQ
G
AL
VGIAMV
L
S
AVFIPM
A
F
FG
G
ST
G
A
IYR
Q
FSIT
IVS
AM
AL
SV
L
VAL
I
LTP
A
LCA
TL
L
KPTSAEHHENKGGFFGWF
N
TT
F
DHSVNH
----
Y
TNSVG
K
I
L
GSTGRY
L
L
I
Y
A
L
IVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VT
DYY
LKNEKAN
V
E
SVF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
NGDENSAE
A
V
I
H
RA
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VEL
G
TA
T
GFDFE
L
IDQAGLGH
D
A
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
L
E
VD
QE
KA
Q
A
L
GVSL
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
ML
P
ED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QG
EA
APGT
S
S
G
D
A
MALMENLASK
L
-
-
P
A
G
IGYD
W
T
G
--
MS
YQ
ER
L
SGNQAPA
L
V
A
-
I
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLM
E
KE
----------
G
KGVV
EA
TLM
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
VS
A
T
LLAI
fig|331111.12.peg.4004
Escherichia coli E24377A (1-1005/1021)
M
L
----
AI
I
L
M
M
A
G
ALA
I
LQ
LPV
A
QYP
T
I
AP
P
A
V
S
V
S
A
N
YPGA
D
AQ
T
V
Q
D
T
VT
Q
VIE
QN
M
NG
I
D
N
LM
Y
MSS
T
S
DSA
G
SVT
ITL
T
F
Q
S
GT
D
PD
I
A
QV
QVQ
NK
LQ
L
A
TPL
LP
QEVQQQ
G
I
SVE-KSSSS
---
Y
L
MVA
G
FV
S
DNPDTTQD
DI
S
D
Y
V
ASN
V
KDT
LS
RLN
GVG
D
V
QLF
G
AQY-AM
RI
W
LD
A
DL
LN
KYK
L
TPVD
V
IN
QL
KVQ
N
DQIAA
GQLGG
T
P
ALPGQQLNAS
I
I
A
QTR
L
K
N
P
EEF
GK
V
T
L
RVNS
DG
SV
V
R
L
K
DVA
R
VE
L
G
G
E
NYNVI
A
RI
NGK
-
P
A
A
G
LG
I
K
L
AT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPF
FP
Q
G
M
K
VLYP
YDTT
PF
V
QL
SI
H
E
VVKT
L
F
EAI
M
LV
F
LV
M
YLFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
A
I
L
A
A
F
G
Y
S
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
D
KLP
P
KE
A
TE
K
SMS
QIQ
G
AL
VGIAMV
L
S
AVFIPM
A
F
FG
G
ST
G
A
IYR
Q
FSIT
IVS
AM
AL
SV
L
VAL
I
LTP
A
LCA
TL
L
KPTSAEHHENKGGFFGWF
N
TT
F
DHSVNH
----
Y
TNSVG
K
I
L
GSTGRY
L
L
I
Y
A
L
IVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VT
DYY
LKNEKAN
V
E
SVF
TVN
S
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
NGDENSAE
A
V
I
H
RA
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VEL
G
TA
T
GFDFE
L
IDQAGLGH
D
A
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
L
E
VD
QE
KA
Q
A
L
GVSL
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
ML
P
ED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QG
EA
APGT
S
S
G
D
A
MALMENLASK
L
-
-
P
A
G
IGYD
W
T
G
--
MS
YQ
ER
L
SGNQAPA
L
V
A
-
I
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLM
E
KE
----------
G
KGVV
EA
TLM
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
VS
A
T
LLAI
fig|409438.11.peg.3715
Escherichia coli SE11 (1-1005/1021)
M
L
----
AI
I
L
M
M
A
G
ALA
I
LQ
LPV
A
QYP
T
I
AP
P
A
V
S
V
S
A
N
YPGA
D
AQ
T
V
Q
D
T
VT
Q
VIE
QN
M
NG
I
D
N
LM
Y
MSS
T
S
DSA
G
SVT
ITL
T
F
Q
S
GT
D
PD
I
A
QV
QVQ
NK
LQ
L
A
TPL
LP
QEVQQQ
G
I
SVE-KSSSS
---
Y
L
MVA
G
FV
S
DNPDTTQD
DI
S
D
Y
V
ASN
V
KDT
LS
RLN
GVG
D
V
QLF
G
AQY-AM
RI
W
LD
A
DL
LN
KYK
L
TPVD
V
IN
QL
KVQ
N
DQIAA
GQLGG
T
P
ALPGQQLNAS
I
I
A
QTR
L
K
N
P
EEF
GK
V
T
L
RVNS
DG
SV
V
R
L
K
DVA
R
VE
L
G
G
E
NYNVI
A
RI
NGK
-
P
A
A
G
LG
I
K
L
AT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPF
FP
Q
G
M
K
VLYP
YDTT
PF
V
QL
SI
H
E
VVKT
L
F
EAI
M
LV
F
LV
M
YLFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
A
I
L
A
A
F
G
Y
S
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
D
KLP
P
KE
A
TE
K
SMS
QIQ
G
AL
VGIAMV
L
S
AVFIPM
A
F
FG
G
ST
G
A
IYR
Q
FSIT
IVS
AM
AL
SV
L
VAL
I
LTP
A
LCA
TL
L
KPTSAEHHENKGGFFGWF
N
TT
F
DHSVNH
----
Y
TNSVG
K
I
L
GSTGRY
L
L
I
Y
A
L
IVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VT
DYY
LKNEKAN
V
E
SVF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
NSDENSAE
A
V
I
H
RA
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VEL
G
TA
T
GFDFE
L
IDQAGLGH
D
A
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
L
E
VD
QE
KA
Q
A
L
GVSL
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
ML
P
ED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QG
EA
APGT
S
S
G
D
A
MALMENLASK
L
-
-
P
A
G
IGYD
W
T
G
--
MS
YQ
ER
L
SGNQAPA
L
V
A
-
I
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLM
E
KE
----------
G
KGVV
EA
TLM
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
VS
A
T
LLAI
fig|340186.5.peg.5008
Escherichia coli E110019 (1-1005/1021)
M
L
----
AI
I
L
M
M
A
G
ALA
I
LQ
LPV
A
QYP
T
I
AP
P
A
V
S
V
S
A
N
YPGA
D
AQ
T
V
Q
D
T
VT
Q
VIE
QN
M
NG
I
D
N
LM
Y
MSS
T
S
DSA
G
SVT
ITL
T
F
Q
S
GT
D
PD
I
A
QV
QVQ
NK
LQ
L
A
TPL
LP
QEVQQQ
G
I
SVE-KSSSS
---
Y
L
MVA
G
FV
S
DNPDTTQD
DI
S
D
Y
V
ASN
V
KDT
LS
RLN
GVG
D
V
QLF
G
AQY-AM
RI
W
LD
A
DL
LN
KYK
L
TPVD
V
IN
QL
KVQ
N
DQIAA
GQLGG
T
P
ALPGQQLNAS
I
I
A
QTR
L
K
N
P
EEF
GK
V
T
L
RVNS
DG
SV
V
R
L
K
DVA
R
VE
L
G
G
E
NYNVI
A
RI
NGK
-
P
A
A
G
LG
I
K
L
AT
GAN
ALV
T
AKA
I
KAK
L
AE
L
QPF
FP
Q
G
M
K
VLYP
YDTT
PF
V
QL
SI
H
E
VVKT
L
F
EAI
M
LV
F
LV
M
YLFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
A
I
L
A
A
F
G
Y
S
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
D
KLP
P
KE
A
TE
K
SMS
QIQ
G
AL
VGIAMV
L
S
AVFIPM
A
F
FG
G
ST
G
A
IYR
Q
FSIT
IVS
AM
AL
SV
L
VAL
I
LTP
A
LCA
TL
L
KPTSAEHHENKGGFFGWF
N
TT
F
DHSVNH
----
Y
TNSVG
K
I
L
GSTGRY
L
L
I
Y
A
L
IVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VT
DYY
LKNEKAN
V
E
SVF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
NGDENSAE
A
V
I
H
RA
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VEL
G
TA
T
GFDFE
L
IDQAGLGH
D
A
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
L
E
VD
QE
KA
Q
A
L
GVSL
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
ML
P
ED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
GS
PR
L
ERY
N
AL
P
SME
I
QG
EA
APGT
S
S
G
D
A
MALMENLASK
L
-
-
P
A
G
IGYD
W
T
G
--
MS
YQ
ER
L
SGNQAPA
L
V
A
-
I
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLM
E
KE
----------
G
KGVV
EA
TLM
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
VS
A
T
LLAI
fig|585034.5.peg.3345
Escherichia coli IAI1 (1-1005/1021)
M
L
----
AI
I
L
M
M
A
G
ALA
I
LQ
LPV
A
QYP
T
I
AP
P
A
V
S
V
S
A
N
YPGA
D
AQ
T
V
Q
D
T
VT
Q
VIE
QN
M
NG
I
D
N
LM
Y
MSS
T
S
DSA
G
SVT
ITL
T
F
Q
S
GT
D
PD
I
A
QV
QVQ
NK
LQ
L
A
TPL
LP
QEVQQQ
G
I
SVE-KSSSS
---
Y
L
MVA
G
FV
S
DNPDTTQD
DI
S
D
Y
V
ASN
V
KDT
LS
RLN
GVG
D
V
QLF
G
AQY-AM
RI
W
LD
A
DL
LN
KYK
L
TPVD
V
IN
QL
KVQ
N
DQIAA
GQLGG
T
P
ALPGQQLNAS
I
I
A
QTR
L
K
N
P
EEF
GK
V
T
L
RVNS
DG
SV
V
R
L
K
DVA
R
VE
L
G
G
E
NYNVI
A
RI
NGK
-
P
A
A
G
LG
I
K
L
AT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPF
FP
Q
G
M
K
VLYP
YDTT
PF
V
QL
SI
H
E
VVKT
L
F
EAI
M
LV
F
LV
M
YLFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
A
I
L
A
A
F
G
Y
S
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
D
KLP
P
KE
A
TE
K
SMS
QIQ
G
AL
VGIAMV
L
S
AVFIPM
A
F
FG
G
ST
G
A
IYR
Q
FSIT
IVS
AM
AL
SV
L
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWF
N
TT
F
DHSVNH
----
Y
TNSVG
K
I
L
GSTGRY
L
L
VY
A
L
IVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VT
DYY
LKNEKAN
V
E
SVF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
NGDENSAE
A
V
I
H
RA
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VEL
G
TA
T
GFDFE
L
IDQAGLGH
D
A
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
L
E
VD
QE
KA
Q
A
L
GVSL
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
ML
P
ED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QG
EA
APGT
S
S
G
D
A
MALMENLASK
L
-
-
P
A
G
IGYD
W
T
G
--
MS
YQ
ER
L
SGNQAPA
L
V
A
-
I
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLM
E
KE
----------
G
KGVV
EA
TLM
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
VS
A
T
LLAI
fig|525281.3.peg.3792
Escherichia coli 83972 (1-1018/1034)
M
ANFF
IRRP
IF
AWV
L
----
AI
I
L
M
M
A
G
ALA
I
LQ
LPV
A
QYP
T
I
AP
P
A
V
S
V
S
A
N
YPGA
D
AQ
T
V
Q
D
T
VT
Q
VIE
QN
M
NG
I
D
N
LM
Y
MSS
T
S
DSA
G
SVT
ITL
T
F
Q
S
GT
D
PD
I
A
QV
QVQ
NK
LQ
L
A
TPL
LP
QEVQQQ
G
I
SVE-KSSSS
---
Y
L
MVA
G
FV
S
DNPGTTQD
DI
S
D
Y
V
ASN
V
KDT
LS
RLN
GVG
D
V
QLF
G
AQY-AM
RI
W
LD
A
DL
LN
KYK
L
TPVD
V
IN
QL
KVQ
N
DQIAA
GQLGG
T
P
ALPGQQLNAS
I
I
A
QTR
L
K
N
P
EEF
GK
V
T
L
RVNS
DG
SV
V
R
L
K
DVA
R
VE
L
G
G
E
NYNVI
A
RI
NGK
-
P
A
A
G
LG
I
K
L
AT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPF
FP
Q
G
M
K
VLYP
YDTT
PF
V
QL
SI
Q
E
VVKT
L
F
EAI
M
LV
F
LV
M
YLFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
A
I
L
A
A
F
G
Y
S
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
D
KLP
P
RE
A
TE
K
SMS
QIQ
G
AL
VGIAMV
L
S
AVFIPM
A
F
FG
G
ST
G
A
IYR
Q
FSIT
IVS
AM
AL
SV
L
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWF
N
TT
F
DHSVNH
----
Y
TNSVG
K
I
L
GSTGRY
L
L
I
Y
A
L
IVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VT
DYY
LKNEKAN
V
E
SVF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
SGDENSAE
A
V
I
H
RA
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VEL
G
TA
T
GFDFE
L
IDQAGLGH
D
A
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
L
E
VD
QE
KA
Q
A
L
GVSL
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
ML
P
ED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QG
EA
APGT
S
S
G
D
A
MALMENLASK
L
-
-
P
A
G
IGYD
W
T
G
--
MS
YQ
ER
L
SGNQAPA
L
V
A
-
I
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLM
E
KE
----------
G
KGVV
EA
TLM
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
VS
A
T
LLAI
fig|655817.3.peg.3849
Escherichia coli ABU 83972 (1-1018/1034)
M
ANFF
IRRP
IF
AWV
L
----
AI
I
L
M
M
A
G
ALA
I
LQ
LPV
A
QYP
T
I
AP
P
A
V
S
V
S
A
N
YPGA
D
AQ
T
V
Q
D
T
VT
Q
VIE
QN
M
NG
I
D
N
LM
Y
MSS
T
S
DSA
G
SVT
ITL
T
F
Q
S
GT
D
PD
I
A
QV
QVQ
NK
LQ
L
A
TPL
LP
QEVQQQ
G
I
SVE-KSSSS
---
Y
L
MVA
G
FV
S
DNPGTTQD
DI
S
D
Y
V
ASN
V
KDT
LS
RLN
GVG
D
V
QLF
G
AQY-AM
RI
W
LD
A
DL
LN
KYK
L
TPVD
V
IN
QL
KVQ
N
DQIAA
GQLGG
T
P
ALPGQQLNAS
I
I
A
QTR
L
K
N
P
EEF
GK
V
T
L
RVNS
DG
SV
V
R
L
K
DVA
R
VE
L
G
G
E
NYNVI
A
RI
NGK
-
P
A
A
G
LG
I
K
L
AT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPF
FP
Q
G
M
K
VLYP
YDTT
PF
V
QL
SI
Q
E
VVKT
L
F
EAI
M
LV
F
LV
M
YLFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
A
I
L
A
A
F
G
Y
S
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
D
KLP
P
RE
A
TE
K
SMS
QIQ
G
AL
VGIAMV
L
S
AVFIPM
A
F
FG
G
ST
G
A
IYR
Q
FSIT
IVS
AM
AL
SV
L
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWF
N
TT
F
DHSVNH
----
Y
TNSVG
K
I
L
GSTGRY
L
L
I
Y
A
L
IVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VT
DYY
LKNEKAN
V
E
SVF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
SGDENSAE
A
V
I
H
RA
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VEL
G
TA
T
GFDFE
L
IDQAGLGH
D
A
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
L
E
VD
QE
KA
Q
A
L
GVSL
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
ML
P
ED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QG
EA
APGT
S
S
G
D
A
MALMENLASK
L
-
-
P
A
G
IGYD
W
T
G
--
MS
YQ
ER
L
SGNQAPA
L
V
A
-
I
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLM
E
KE
----------
G
KGVV
EA
TLM
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
VS
A
T
LLAI
fig|405955.13.peg.3687
Escherichia coli APEC O1 (1-1018/1034)
M
ANFF
IRRP
IF
AWV
L
----
AI
I
L
M
M
A
G
ALA
I
LQ
LPV
A
QYP
T
I
AP
P
A
V
S
V
S
A
N
YPGA
D
AQ
T
V
Q
D
T
VT
Q
VIE
QN
M
NG
I
D
N
LM
Y
MSS
T
S
DSA
G
SVT
ITL
T
F
Q
S
GT
D
PD
I
A
QV
QVQ
NK
LQ
L
A
TPL
LP
QEVQQQ
G
I
SVE-KSSSS
---
Y
L
MVA
G
FV
S
DNPGTTQD
DI
S
D
Y
V
ASN
V
KDT
LS
RLN
GVG
D
V
QLF
G
AQY-AM
RI
W
LD
A
DL
LN
KYK
L
TPVD
V
IN
QL
KVQ
N
DQIAA
GQLGG
T
P
ALPGQQLNAS
I
I
A
QTR
L
K
N
P
EEF
GK
V
T
L
RVNS
DG
SV
V
R
L
K
DVA
R
VE
L
G
G
E
NYNVI
A
RI
NGK
-
P
A
A
G
LG
I
K
L
AT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPF
FP
Q
G
M
K
VLYP
YDTT
PF
V
QL
SI
Q
E
VVKT
L
F
EAI
M
LV
F
LV
M
YLFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
A
I
L
A
A
F
G
Y
S
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
D
KLP
P
RE
A
TE
K
SMS
QIQ
G
AL
VGIAMV
L
S
AVFIPM
A
F
FG
G
ST
G
A
IYR
Q
FSIT
IVS
AM
AL
SV
L
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWF
N
TT
F
DHSVNH
----
Y
TNSVG
K
I
L
GSTGRY
L
L
I
Y
A
L
IVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VT
DYY
LKNEKAN
V
E
SVF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
SGDENSAE
A
V
I
H
RA
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VEL
G
TA
T
GFDFE
L
IDQAGLGH
D
A
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
L
E
VD
QE
KA
Q
A
L
GVSL
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
ML
P
ED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QG
EA
APGT
S
S
G
D
A
MALMENLASK
L
-
-
P
A
G
IGYD
W
T
G
--
MS
YQ
ER
L
SGNQAPA
L
V
A
-
I
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLM
E
KE
----------
G
KGVV
EA
TLM
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
VS
A
T
LLAI
fig|405955.9.peg.3079
Escherichia coli APEC O1 (1-1018/1034)
M
ANFF
IRRP
IF
AWV
L
----
AI
I
L
M
M
A
G
ALA
I
LQ
LPV
A
QYP
T
I
AP
P
A
V
S
V
S
A
N
YPGA
D
AQ
T
V
Q
D
T
VT
Q
VIE
QN
M
NG
I
D
N
LM
Y
MSS
T
S
DSA
G
SVT
ITL
T
F
Q
S
GT
D
PD
I
A
QV
QVQ
NK
LQ
L
A
TPL
LP
QEVQQQ
G
I
SVE-KSSSS
---
Y
L
MVA
G
FV
S
DNPGTTQD
DI
S
D
Y
V
ASN
V
KDT
LS
RLN
GVG
D
V
QLF
G
AQY-AM
RI
W
LD
A
DL
LN
KYK
L
TPVD
V
IN
QL
KVQ
N
DQIAA
GQLGG
T
P
ALPGQQLNAS
I
I
A
QTR
L
K
N
P
EEF
GK
V
T
L
RVNS
DG
SV
V
R
L
K
DVA
R
VE
L
G
G
E
NYNVI
A
RI
NGK
-
P
A
A
G
LG
I
K
L
AT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPF
FP
Q
G
M
K
VLYP
YDTT
PF
V
QL
SI
Q
E
VVKT
L
F
EAI
M
LV
F
LV
M
YLFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
A
I
L
A
A
F
G
Y
S
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
D
KLP
P
RE
A
TE
K
SMS
QIQ
G
AL
VGIAMV
L
S
AVFIPM
A
F
FG
G
ST
G
A
IYR
Q
FSIT
IVS
AM
AL
SV
L
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWF
N
TT
F
DHSVNH
----
Y
TNSVG
K
I
L
GSTGRY
L
L
I
Y
A
L
IVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VT
DYY
LKNEKAN
V
E
SVF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
SGDENSAE
A
V
I
H
RA
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VEL
G
TA
T
GFDFE
L
IDQAGLGH
D
A
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
L
E
VD
QE
KA
Q
A
L
GVSL
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
ML
P
ED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QG
EA
APGT
S
S
G
D
A
MALMENLASK
L
-
-
P
A
G
IGYD
W
T
G
--
MS
YQ
ER
L
SGNQAPA
L
V
A
-
I
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLM
E
KE
----------
G
KGVV
EA
TLM
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
VS
A
T
LLAI
fig|714962.3.peg.3724
Escherichia coli IHE3034 (1-1018/1034)
M
ANFF
IRRP
IF
AWV
L
----
AI
I
L
M
M
A
G
ALA
I
LQ
LPV
A
QYP
T
I
AP
P
A
V
S
V
S
A
N
YPGA
D
AQ
T
V
Q
D
T
VT
Q
VIE
QN
M
NG
I
D
N
LM
Y
MSS
T
S
DSA
G
SVT
ITL
T
F
Q
S
GT
D
PD
I
A
QV
QVQ
NK
LQ
L
A
TPL
LP
QEVQQQ
G
I
SVE-KSSSS
---
Y
L
MVA
G
FV
S
DNPGTTQD
DI
S
D
Y
V
ASN
V
KDT
LS
RLN
GVG
D
V
QLF
G
AQY-AM
RI
W
LD
A
DL
LN
KYK
L
TPVD
V
IN
QL
KVQ
N
DQIAA
GQLGG
T
P
ALPGQQLNAS
I
I
A
QTR
L
K
N
P
EEF
GK
V
T
L
RVNS
DG
SV
V
R
L
K
DVA
R
VE
L
G
G
E
NYNVI
A
RI
NGK
-
P
A
A
G
LG
I
K
L
AT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPF
FP
Q
G
M
K
VLYP
YDTT
PF
V
QL
SI
Q
E
VVKT
L
F
EAI
M
LV
F
LV
M
YLFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
A
I
L
A
A
F
G
Y
S
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
D
KLP
P
RE
A
TE
K
SMS
QIQ
G
AL
VGIAMV
L
S
AVFIPM
A
F
FG
G
ST
G
A
IYR
Q
FSIT
IVS
AM
AL
SV
L
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWF
N
TT
F
DHSVNH
----
Y
TNSVG
K
I
L
GSTGRY
L
L
I
Y
A
L
IVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VT
DYY
LKNEKAN
V
E
SVF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
SGDENSAE
A
V
I
H
RA
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VEL
G
TA
T
GFDFE
L
IDQAGLGH
D
A
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
L
E
VD
QE
KA
Q
A
L
GVSL
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
ML
P
ED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QG
EA
APGT
S
S
G
D
A
MALMENLASK
L
-
-
P
A
G
IGYD
W
T
G
--
MS
YQ
ER
L
SGNQAPA
L
V
A
-
I
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLM
E
KE
----------
G
KGVV
EA
TLM
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
VS
A
T
LLAI
fig|749528.3.peg.4231
Escherichia coli MS 45-1 (1-1018/1034)
M
ANFF
IRRP
IF
AWV
L
----
AI
I
L
M
M
A
G
ALA
I
LQ
LPV
A
QYP
T
I
AP
P
A
V
S
V
S
A
N
YPGA
D
AQ
T
V
Q
D
T
VT
Q
VIE
QN
M
NG
I
D
N
LM
Y
MSS
T
S
DSA
G
SVT
ITL
T
F
Q
S
GT
D
PD
I
A
QV
QVQ
NK
LQ
L
A
TPL
LP
QEVQQQ
G
I
SVE-KSSSS
---
Y
L
MVA
G
FV
S
DNPGTTQD
DI
S
D
Y
V
ASN
V
KDT
LS
RLN
GVG
D
V
QLF
G
AQY-AM
RI
W
LD
A
DL
LN
KYK
L
TPVD
V
IN
QL
KVQ
N
DQIAA
GQLGG
T
P
ALPGQQLNAS
I
I
A
QTR
L
K
N
P
EEF
GK
V
T
L
RVNS
DG
SV
V
R
L
K
DVA
R
VE
L
G
G
E
NYNVI
A
RI
NGK
-
P
A
A
G
LG
I
K
L
AT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPF
FP
Q
G
M
K
VLYP
YDTT
PF
V
QL
SI
Q
E
VVKT
L
F
EAI
M
LV
F
LV
M
YLFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
A
I
L
A
A
F
G
Y
S
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
D
KLP
P
RE
A
TE
K
SMS
QIQ
G
AL
VGIAMV
L
S
AVFIPM
A
F
FG
G
ST
G
A
IYR
Q
FSIT
IVS
AM
AL
SV
L
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWF
N
TT
F
DHSVNH
----
Y
TNSVG
K
I
L
GSTGRY
L
L
I
Y
A
L
IVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VT
DYY
LKNEKAN
V
E
SVF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
SGDENSAE
A
V
I
H
RA
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VEL
G
TA
T
GFDFE
L
IDQAGLGH
D
A
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
L
E
VD
QE
KA
Q
A
L
GVSL
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
ML
P
ED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QG
EA
APGT
S
S
G
D
A
MALMENLASK
L
-
-
P
A
G
IGYD
W
T
G
--
MS
YQ
ER
L
SGNQAPA
L
V
A
-
I
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLM
E
KE
----------
G
KGVV
EA
TLM
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
VS
A
T
LLAI
fig|585035.6.peg.3587
Escherichia coli S88 (1-1018/1034)
M
ANFF
IRRP
IF
AWV
L
----
AI
I
L
M
M
A
G
ALA
I
LQ
LPV
A
QYP
T
I
AP
P
A
V
S
V
S
A
N
YPGA
D
AQ
T
V
Q
D
T
VT
Q
VIE
QN
M
NG
I
D
N
LM
Y
MSS
T
S
DSA
G
SVT
ITL
T
F
Q
S
GT
D
PD
I
A
QV
QVQ
NK
LQ
L
A
TPL
LP
QEVQQQ
G
I
SVE-KSSSS
---
Y
L
MVA
G
FV
S
DNPGTTQD
DI
S
D
Y
V
ASN
V
KDT
LS
RLN
GVG
D
V
QLF
G
AQY-AM
RI
W
LD
A
DL
LN
KYK
L
TPVD
V
IN
QL
KVQ
N
DQIAA
GQLGG
T
P
ALPGQQLNAS
I
I
A
QTR
L
K
N
P
EEF
GK
V
T
L
RVNS
DG
SV
V
R
L
K
DVA
R
VE
L
G
G
E
NYNVI
A
RI
NGK
-
P
A
A
G
LG
I
K
L
AT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPF
FP
Q
G
M
K
VLYP
YDTT
PF
V
QL
SI
Q
E
VVKT
L
F
EAI
M
LV
F
LV
M
YLFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
A
I
L
A
A
F
G
Y
S
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
D
KLP
P
RE
A
TE
K
SMS
QIQ
G
AL
VGIAMV
L
S
AVFIPM
A
F
FG
G
ST
G
A
IYR
Q
FSIT
IVS
AM
AL
SV
L
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWF
N
TT
F
DHSVNH
----
Y
TNSVG
K
I
L
GSTGRY
L
L
I
Y
A
L
IVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VT
DYY
LKNEKAN
V
E
SVF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
SGDENSAE
A
V
I
H
RA
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VEL
G
TA
T
GFDFE
L
IDQAGLGH
D
A
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
L
E
VD
QE
KA
Q
A
L
GVSL
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
ML
P
ED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QG
EA
APGT
S
S
G
D
A
MALMENLASK
L
-
-
P
A
G
IGYD
W
T
G
--
MS
YQ
ER
L
SGNQAPA
L
V
A
-
I
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLM
E
KE
----------
G
KGVV
EA
TLM
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
VS
A
T
LLAI
fig|656440.3.peg.3505
Escherichia coli TA206 (1-1018/1034)
M
ANFF
IRRP
IF
AWV
L
----
AI
I
L
M
M
A
G
ALA
I
LQ
LPV
A
QYP
T
I
AP
P
A
V
S
V
S
A
N
YPGA
D
AQ
T
V
Q
D
T
VT
Q
VIE
QN
M
NG
I
D
N
LM
Y
MSS
T
S
DSA
G
SVT
ITL
T
F
Q
S
GT
D
PD
I
A
QV
QVQ
NK
LQ
L
A
TPL
LP
QEVQQQ
G
I
SVE-KSSSS
---
Y
L
MVA
G
FV
S
DNPGTTQD
DI
S
D
Y
V
ASN
V
KDT
LS
RLN
GVG
D
V
QLF
G
AQY-AM
RI
W
LD
A
DL
LN
KYK
L
TPVD
V
IN
QL
KVQ
N
DQIAA
GQLGG
T
P
ALPGQQLNAS
I
I
A
QTR
L
K
N
P
EEF
GK
V
T
L
RVNS
DG
SV
V
R
L
K
DVA
R
VE
L
G
G
E
NYNVI
A
RI
NGK
-
P
A
A
G
LG
I
K
L
AT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPF
FP
Q
G
M
K
VLYP
YDTT
PF
V
QL
SI
Q
E
VVKT
L
F
EAI
M
LV
F
LV
M
YLFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
A
I
L
A
A
F
G
Y
S
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
D
KLP
P
RE
A
TE
K
SMS
QIQ
G
AL
VGIAMV
L
S
AVFIPM
A
F
FG
G
ST
G
A
IYR
Q
FSIT
IVS
AM
AL
SV
L
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWF
N
TT
F
DHSVNH
----
Y
TNSVG
K
I
L
GSTGRY
L
L
I
Y
A
L
IVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VT
DYY
LKNEKAN
V
E
SVF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
SGDENSAE
A
V
I
H
RA
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VEL
G
TA
T
GFDFE
L
IDQAGLGH
D
A
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
L
E
VD
QE
KA
Q
A
L
GVSL
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
ML
P
ED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QG
EA
APGT
S
S
G
D
A
MALMENLASK
L
-
-
P
A
G
IGYD
W
T
G
--
MS
YQ
ER
L
SGNQAPA
L
V
A
-
I
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLM
E
KE
----------
G
KGVV
EA
TLM
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
VS
A
T
LLAI
fig|869729.3.peg.6
Escherichia coli UM146 (1-1018/1034)
M
ANFF
IRRP
IF
AWV
L
----
AI
I
L
M
M
A
G
ALA
I
LQ
LPV
A
QYP
T
I
AP
P
A
V
S
V
S
A
N
YPGA
D
AQ
T
V
Q
D
T
VT
Q
VIE
QN
M
NG
I
D
N
LM
Y
MSS
T
S
DSA
G
SVT
ITL
T
F
Q
S
GT
D
PD
I
A
QV
QVQ
NK
LQ
L
A
TPL
LP
QEVQQQ
G
I
SVE-KSSSS
---
Y
L
MVA
G
FV
S
DNPGTTQD
DI
S
D
Y
V
ASN
V
KDT
LS
RLN
GVG
D
V
QLF
G
AQY-AM
RI
W
LD
A
DL
LN
KYK
L
TPVD
V
IN
QL
KVQ
N
DQIAA
GQLGG
T
P
ALPGQQLNAS
I
I
A
QTR
L
K
N
P
EEF
GK
V
T
L
RVNS
DG
SV
V
R
L
K
DVA
R
VE
L
G
G
E
NYNVI
A
RI
NGK
-
P
A
A
G
LG
I
K
L
AT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPF
FP
Q
G
M
K
VLYP
YDTT
PF
V
QL
SI
Q
E
VVKT
L
F
EAI
M
LV
F
LV
M
YLFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
A
I
L
A
A
F
G
Y
S
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
D
KLP
P
RE
A
TE
K
SMS
QIQ
G
AL
VGIAMV
L
S
AVFIPM
A
F
FG
G
ST
G
A
IYR
Q
FSIT
IVS
AM
AL
SV
L
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWF
N
TT
F
DHSVNH
----
Y
TNSVG
K
I
L
GSTGRY
L
L
I
Y
A
L
IVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VT
DYY
LKNEKAN
V
E
SVF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
SGDENSAE
A
V
I
H
RA
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VEL
G
TA
T
GFDFE
L
IDQAGLGH
D
A
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
L
E
VD
QE
KA
Q
A
L
GVSL
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
ML
P
ED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QG
EA
APGT
S
S
G
D
A
MALMENLASK
L
-
-
P
A
G
IGYD
W
T
G
--
MS
YQ
ER
L
SGNQAPA
L
V
A
-
I
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLM
E
KE
----------
G
KGVV
EA
TLM
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
VS
A
T
LLAI
fig|364106.7.peg.3660
Escherichia coli UTI89 (1-1018/1034)
M
ANFF
IRRP
IF
AWV
L
----
AI
I
L
M
M
A
G
ALA
I
LQ
LPV
A
QYP
T
I
AP
P
A
V
S
V
S
A
N
YPGA
D
AQ
T
V
Q
D
T
VT
Q
VIE
QN
M
NG
I
D
N
LM
Y
MSS
T
S
DSA
G
SVT
ITL
T
F
Q
S
GT
D
PD
I
A
QV
QVQ
NK
LQ
L
A
TPL
LP
QEVQQQ
G
I
SVE-KSSSS
---
Y
L
MVA
G
FV
S
DNPGTTQD
DI
S
D
Y
V
ASN
V
KDT
LS
RLN
GVG
D
V
QLF
G
AQY-AM
RI
W
LD
A
DL
LN
KYK
L
TPVD
V
IN
QL
KVQ
N
DQIAA
GQLGG
T
P
ALPGQQLNAS
I
I
A
QTR
L
K
N
P
EEF
GK
V
T
L
RVNS
DG
SV
V
R
L
K
DVA
R
VE
L
G
G
E
NYNVI
A
RI
NGK
-
P
A
A
G
LG
I
K
L
AT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPF
FP
Q
G
M
K
VLYP
YDTT
PF
V
QL
SI
Q
E
VVKT
L
F
EAI
M
LV
F
LV
M
YLFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
A
I
L
A
A
F
G
Y
S
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
D
KLP
P
RE
A
TE
K
SMS
QIQ
G
AL
VGIAMV
L
S
AVFIPM
A
F
FG
G
ST
G
A
IYR
Q
FSIT
IVS
AM
AL
SV
L
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWF
N
TT
F
DHSVNH
----
Y
TNSVG
K
I
L
GSTGRY
L
L
I
Y
A
L
IVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VT
DYY
LKNEKAN
V
E
SVF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
SGDENSAE
A
V
I
H
RA
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VEL
G
TA
T
GFDFE
L
IDQAGLGH
D
A
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
L
E
VD
QE
KA
Q
A
L
GVSL
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
ML
P
ED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QG
EA
APGT
S
S
G
D
A
MALMENLASK
L
-
-
P
A
G
IGYD
W
T
G
--
MS
YQ
ER
L
SGNQAPA
L
V
A
-
I
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLM
E
KE
----------
G
KGVV
EA
TLM
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
VS
A
T
LLAI
fig|364106.8.peg.3661
Escherichia coli UTI89 (1-1018/1034)
M
ANFF
IRRP
IF
AWV
L
----
AI
I
L
M
M
A
G
ALA
I
LQ
LPV
A
QYP
T
I
AP
P
A
V
S
V
S
A
N
YPGA
D
AQ
T
V
Q
D
T
VT
Q
VIE
QN
M
NG
I
D
N
LM
Y
MSS
T
S
DSA
G
SVT
ITL
T
F
Q
S
GT
D
PD
I
A
QV
QVQ
NK
LQ
L
A
TPL
LP
QEVQQQ
G
I
SVE-KSSSS
---
Y
L
MVA
G
FV
S
DNPGTTQD
DI
S
D
Y
V
ASN
V
KDT
LS
RLN
GVG
D
V
QLF
G
AQY-AM
RI
W
LD
A
DL
LN
KYK
L
TPVD
V
IN
QL
KVQ
N
DQIAA
GQLGG
T
P
ALPGQQLNAS
I
I
A
QTR
L
K
N
P
EEF
GK
V
T
L
RVNS
DG
SV
V
R
L
K
DVA
R
VE
L
G
G
E
NYNVI
A
RI
NGK
-
P
A
A
G
LG
I
K
L
AT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPF
FP
Q
G
M
K
VLYP
YDTT
PF
V
QL
SI
Q
E
VVKT
L
F
EAI
M
LV
F
LV
M
YLFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
A
I
L
A
A
F
G
Y
S
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
D
KLP
P
RE
A
TE
K
SMS
QIQ
G
AL
VGIAMV
L
S
AVFIPM
A
F
FG
G
ST
G
A
IYR
Q
FSIT
IVS
AM
AL
SV
L
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWF
N
TT
F
DHSVNH
----
Y
TNSVG
K
I
L
GSTGRY
L
L
I
Y
A
L
IVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VT
DYY
LKNEKAN
V
E
SVF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
SGDENSAE
A
V
I
H
RA
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VEL
G
TA
T
GFDFE
L
IDQAGLGH
D
A
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
L
E
VD
QE
KA
Q
A
L
GVSL
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
ML
P
ED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QG
EA
APGT
S
S
G
D
A
MALMENLASK
L
-
-
P
A
G
IGYD
W
T
G
--
MS
YQ
ER
L
SGNQAPA
L
V
A
-
I
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLM
E
KE
----------
G
KGVV
EA
TLM
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
VS
A
T
LLAI
fig|749547.3.peg.1020
Escherichia coli MS 187-1 (1-1018/1034)
M
ANFF
IRRP
IF
AWV
L
----
AI
I
L
M
M
A
G
ALA
I
LQ
LPV
A
QYP
T
I
AP
P
A
V
S
V
S
A
N
YPGA
D
AQ
T
V
Q
D
T
VT
Q
VIE
QN
M
NG
I
D
N
LM
Y
MSS
T
S
DSA
G
SVT
ITL
T
F
Q
S
GT
D
PD
I
A
QV
QVQ
NK
LQ
L
A
TPL
LP
QEVQQQ
G
I
SVE-KSSSS
---
Y
L
MVA
G
FV
S
DNPDITQD
DI
S
D
Y
V
ASN
V
KDT
LS
RLN
GVG
D
V
QLF
G
AQY-AM
RI
W
LD
A
DL
LN
KYK
L
TPVD
V
IN
QL
KVQ
N
DQIAA
GQLGG
T
P
ALPGQQLNAS
I
I
A
QTR
L
K
N
P
EEF
GK
V
T
L
RVNS
DG
SV
V
R
L
K
DVA
R
VE
L
G
G
E
NYNVI
A
RI
NGK
-
P
A
A
G
LG
I
K
L
AT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPF
FP
Q
G
M
K
VLYP
YDTT
PF
V
QL
SI
H
E
VVKT
L
F
EAI
M
LV
F
LV
M
YLFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
A
I
L
A
A
F
G
Y
S
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
D
KLP
P
KE
A
TE
K
SMS
QIQ
G
AL
VGIAMV
L
S
AVFIPM
A
F
FG
G
ST
G
A
IYR
Q
FSIT
IVS
AM
AL
SV
L
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWF
N
TT
F
DHSVNH
----
Y
TNSVG
K
I
L
GSTGRY
L
L
I
Y
A
L
IVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VT
DYY
LKNEKAN
V
E
SVF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
NGDENSAE
A
V
I
H
RA
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VEL
G
TA
T
GFDFE
L
IDQAGLGH
D
A
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
L
E
VD
QE
KA
Q
A
L
GVSL
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
ML
P
ED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QG
EA
APGT
S
S
G
D
A
MALMENLASK
L
-
-
P
A
G
IGYD
W
T
G
--
MS
YQ
ER
L
SGNQAPA
L
V
A
-
I
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLM
E
KE
----------
G
KGVV
EA
TLM
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
VS
A
T
LLAI
fig|656417.3.peg.4107
Escherichia coli M605 (1-1018/1034)
M
ANFF
IRRP
IF
AWV
L
----
AI
I
L
M
M
A
G
ALA
I
LQ
LPV
A
QYP
T
I
AP
P
A
V
S
V
S
A
N
YPGA
D
AQ
T
V
Q
D
T
VT
Q
VIE
QN
M
NG
I
D
N
LM
Y
MSS
T
S
DSA
G
SVT
ITL
T
F
Q
S
GT
D
PD
I
A
QV
QVQ
NK
LQ
L
A
TPL
LP
QEVQQQ
G
I
SVE-KSSSS
---
Y
L
MVA
G
FV
S
DNPGTTQD
DI
S
D
Y
V
ASN
V
KDT
LS
RLN
GVG
D
V
QLF
G
AQY-AM
RI
W
LD
A
DL
LN
KYK
L
TPVD
V
IN
QL
KVQ
N
DQIAA
GQLGG
T
P
ALPGQQLNAS
I
I
A
QTR
L
K
N
P
EEF
GK
V
T
L
RVNS
DG
SV
V
R
L
K
DVA
R
VE
L
G
G
E
NYNVI
A
RI
NGK
-
P
A
A
G
LG
I
K
L
AT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPF
FP
Q
G
M
K
VLYP
YDTT
PF
V
QL
SI
H
E
VVKT
L
F
EAI
M
LV
F
LV
M
YLFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
A
I
L
A
A
F
G
Y
S
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
D
KLP
P
RE
A
TE
K
SMS
QIQ
G
AL
VGIAMV
L
S
AVFIPM
A
F
FG
G
ST
G
A
IYR
Q
FSIT
IVS
AM
AL
SV
L
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWF
N
TT
F
DHSVNH
----
Y
TNSVG
K
I
L
GSTGRY
L
L
I
Y
A
L
IVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VT
DYY
LKNEKAN
V
E
SVF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
SGDENSAE
A
V
I
H
RA
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VEL
G
TA
T
GFDFE
L
IDQAGLGH
D
A
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
L
E
VD
QE
KA
Q
A
L
GVSL
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
ML
P
ED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QG
EA
APGT
S
S
G
D
A
MALMENLASK
L
-
-
P
A
G
IGYD
W
T
G
--
MS
YQ
ER
L
SGNQAPA
L
V
A
-
I
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLM
E
KE
----------
G
KGVV
EA
TLM
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
VS
A
T
LLAI
fig|753642.3.peg.4693
Escherichia coli NC101 (1-1018/1034)
M
ANFF
IRRP
IF
AWV
L
----
AI
I
L
M
M
A
G
ALA
I
LQ
LPV
A
QYP
T
I
AP
P
A
V
S
V
S
A
N
YPGA
D
AQ
T
V
Q
D
T
VT
Q
VIE
QN
M
NG
I
D
N
LM
Y
MSS
T
S
DSA
G
SVT
ITL
T
F
Q
S
GT
D
PD
I
A
QV
QVQ
NK
LQ
L
A
TPL
LP
QEVQQQ
G
I
SVE-KSSSS
---
Y
L
MVA
G
FV
S
DNPGTTQD
DI
S
D
Y
V
ASN
V
KDT
LS
RLN
GVG
D
V
QLF
G
AQY-AM
RI
W
LD
A
DL
LN
KYK
L
TPVD
V
IN
QL
KVQ
N
DQIAA
GQLGG
T
P
ALPGQQLNAS
I
I
A
QTR
L
K
N
P
EEF
GK
V
T
L
RVNS
DG
SV
V
R
L
K
DVA
R
VE
L
G
G
E
NYNVI
A
RI
NGK
-
P
A
A
G
LG
I
K
L
AT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPF
FP
Q
G
M
K
VLYP
YDTT
PF
V
QL
SI
H
E
VVKT
L
F
EAI
M
LV
F
LV
M
YLFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
A
I
L
A
A
F
G
Y
S
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
D
KLP
P
RE
A
TE
K
SMS
QIQ
G
AL
VGIAMV
L
S
AVFIPM
A
F
FG
G
ST
G
A
IYR
Q
FSIT
IVS
AM
AL
SV
L
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWF
N
TT
F
DHSVNH
----
Y
TNSVG
K
I
L
GSTGRY
L
L
I
Y
A
L
IVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VT
DYY
LKNEKAN
V
E
SVF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
SGDENSAE
A
V
I
H
RA
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VEL
G
TA
T
GFDFE
L
IDQAGLGH
D
A
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
L
E
VD
QE
KA
Q
A
L
GVSL
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
ML
P
ED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QG
EA
APGT
S
S
G
D
A
MALMENLASK
L
-
-
P
A
G
IGYD
W
T
G
--
MS
YQ
ER
L
SGNQAPA
L
V
A
-
I
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLM
E
KE
----------
G
KGVV
EA
TLM
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
VS
A
T
LLAI
fig|685038.3.peg.3308
Escherichia coli O83:H1 str. NRG 857C (1-1018/1034)
M
ANFF
IRRP
IF
AWV
L
----
AI
I
L
M
M
A
G
VLA
I
LQ
LPV
A
QYP
T
I
AP
P
A
V
S
V
S
A
N
YPGA
D
AQ
T
V
Q
D
T
VT
Q
VIE
QN
M
NG
I
D
N
LM
Y
MSS
T
S
DSA
G
SVT
ITL
T
F
Q
S
GT
D
PD
I
A
QV
QVQ
NK
LQ
L
A
TPL
LP
QEVQQQ
G
I
SVE-KSSSS
---
Y
L
MVA
G
FV
S
DNPGTTQD
DI
S
D
Y
V
ASN
V
KDT
LS
RLN
GVG
D
V
QLF
G
AQY-AM
RI
W
LD
A
DL
LN
KYK
L
TPVD
V
IN
QL
KVQ
N
DQIAA
GQLGG
T
P
ALPGQQLNAS
I
I
A
QTR
L
K
N
P
EEF
GK
V
T
L
RVNS
DG
SV
V
R
L
K
DVA
R
VE
L
G
G
E
NYNVI
A
RI
NGK
-
P
A
A
G
LG
I
K
L
AT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPF
FP
Q
G
M
K
VLYP
YDTT
PF
V
QL
SI
H
E
VVKT
L
F
EAI
M
LV
F
LV
M
YLFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
A
I
L
A
A
F
G
Y
S
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
D
KLP
P
RE
A
TE
K
SMS
QIQ
G
AL
VGIAMV
L
S
AVFIPM
A
F
FG
G
ST
G
A
IYR
Q
FSIT
IVS
AM
AL
SV
L
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWF
N
TT
F
DHSVNH
----
Y
TNSVG
K
I
L
GSTGRY
L
L
I
Y
A
L
IVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VT
DYY
LKNEKAN
V
E
SVF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
SGDENSAE
A
V
I
H
RA
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VEL
G
TA
T
GFDFE
L
IDQAGLGH
D
A
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
L
E
VD
QE
KA
Q
A
L
GVSL
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
ML
P
ED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QG
EA
APGT
S
S
G
D
A
MALMENLASK
L
-
-
P
A
G
IGYD
W
T
G
--
MS
YQ
ER
L
SGNQAPA
L
V
A
-
I
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLM
E
KE
----------
G
KGVV
EA
TLM
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
VS
A
T
LLAI
fig|6666666.5357.peg.2522
Escherichia coli TY-2482 (1-1018/1034)
M
ANFF
IRRP
IF
AWV
L
----
AI
I
L
M
M
A
G
ALA
I
LQ
LPV
A
QYP
T
I
AP
P
A
V
S
V
S
A
N
YPGA
D
AQ
T
V
Q
D
T
VT
Q
VIE
QN
M
NG
I
D
N
LM
Y
MSS
T
S
DSA
G
SVT
ITL
T
F
Q
S
GT
D
PD
I
A
QV
QVQ
NK
LQ
L
A
TPL
LP
QEVQQQ
G
I
SVE-KSSSS
---
Y
L
MVA
G
FV
S
DNPDTTQD
DI
S
D
Y
V
ASN
V
KDT
LS
RLN
GVG
D
V
QLF
G
AQY-AM
RI
W
LD
A
DL
LN
KYK
L
TPVD
V
IN
QL
KVQ
N
DQIAA
GQLGG
T
P
ALPGQQLNAS
I
I
A
QTR
L
K
N
P
EEF
GK
V
T
L
RVNS
DG
SV
V
R
L
K
DVA
R
VE
L
G
G
E
NYNVI
A
RI
NGK
-
P
A
A
G
LG
I
K
L
AT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPF
FP
Q
G
M
K
VLYP
YDTT
PF
V
QL
SI
H
E
VVKT
L
F
EAI
M
LV
F
LV
M
YLFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
A
I
L
A
A
F
G
Y
S
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
D
KLP
P
KE
A
TE
K
SMS
QIQ
G
AL
VGIAMV
L
S
AVFIPM
A
F
FG
G
ST
G
A
IYR
Q
FSIT
IVS
AM
AL
SV
L
VAL
I
LTP
A
LCA
TL
L
KPTSAEHHENKGGFFGWF
N
TT
F
DHSVNH
----
Y
TNSVG
K
I
L
GSTGRY
L
L
I
Y
A
L
IVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VT
DYY
LKNEKAN
V
E
SVF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
NSDENSAE
A
V
I
H
RA
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VEL
G
TA
T
GFDFE
L
IDQAGLGH
D
A
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
L
E
VD
QE
KA
Q
A
L
GVSL
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
ML
P
ED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QG
EA
APGT
S
S
G
D
A
MALMENLASK
L
-
-
P
A
G
IGYD
W
T
G
--
MS
YQ
ER
L
SGNQAPA
L
V
A
-
I
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATPH
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLM
E
KE
----------
G
KGVV
EA
TLM
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
VS
A
T
LLAI
fig|344601.3.peg.4583
Escherichia coli B171 (1-1018/1034)
M
ANFF
IRRP
IF
AWV
L
----
AI
I
L
M
M
A
G
ALA
I
LQ
LPV
A
QYP
T
I
AP
P
A
V
S
V
S
A
N
YPGA
D
AQ
T
V
Q
D
T
VT
Q
VIE
QN
M
NG
I
D
N
LM
Y
MSS
T
S
DSA
G
SVT
ITL
T
F
Q
S
GT
D
PD
I
A
QV
QVQ
NK
LQ
L
A
TPL
LP
QEVQQQ
G
I
SVE-KSSSS
---
Y
L
MVA
G
FV
S
DNPDTTQD
DI
S
D
Y
V
ASN
V
KDT
LS
RLN
GVG
D
V
QLF
G
AQY-AM
RI
W
LD
A
DL
LN
KYK
L
TPVD
V
IN
QL
KVQ
N
DQIAA
GQLGG
T
P
ALPGQQLNAS
I
I
A
QTR
L
K
N
P
EEF
GK
V
T
L
RVNS
DG
SV
V
R
L
K
DVA
R
VE
L
G
G
E
NYNVI
A
RI
NGK
-
P
A
A
G
LG
I
K
L
AT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPF
FP
Q
G
M
K
VLYP
YDTT
PF
V
QL
SI
H
E
VVKT
L
F
EAI
M
LV
F
LV
M
YLFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
A
I
L
A
A
F
G
Y
S
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
D
KLP
P
KE
A
TE
K
SMS
QIQ
G
AL
VGIAMV
L
S
AVFIPM
A
F
FG
G
ST
G
A
IYR
Q
FSIT
IVS
AM
AL
SV
L
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWF
N
TT
F
DHSVNH
----
Y
TNSVG
K
I
L
GSTGRY
L
L
I
Y
A
L
IVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VT
DYY
LKNEKAN
V
E
SVF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
NGDENSAE
A
V
I
H
RA
KMEFGKIRDGF
V
I--
P
F
-
NMPA
I
VEL
G
TA
T
GFDFE
L
IDQAGLGH
D
A
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
L
E
VD
QE
KA
Q
A
L
GVSL
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
ML
P
ED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QG
EA
APGT
S
S
G
D
A
MALMENLASK
L
-
-
P
A
G
IGYD
W
T
G
--
MS
YQ
ER
L
SGNQAPA
L
V
A
-
I
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLM
E
KE
----------
G
KGVV
EA
TLM
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
VS
A
T
LLAI
fig|340185.3.peg.4834
Escherichia coli E22 (1-1018/1034)
M
ANFF
IRRP
IF
AWV
L
----
AI
I
L
M
M
A
G
ALA
I
LQ
LPV
A
QYP
T
I
AP
P
A
V
S
V
S
A
N
YPGA
D
AQ
T
V
Q
D
T
VT
Q
VIE
QN
M
NG
I
D
N
LM
Y
MSS
T
S
DSA
G
SVT
ITL
T
F
Q
S
GT
D
PD
I
A
QV
QVQ
NK
LQ
L
A
TPL
LP
QEVQQQ
G
I
SVE-KSSSS
---
Y
L
MVA
G
FV
S
DNPDTTQD
DI
S
D
Y
V
ASN
V
KDT
LS
RLN
GVG
D
V
QLF
G
AQY-AM
RI
W
LD
A
DL
LN
KYK
L
TPVD
V
IN
QL
KVQ
N
DQIAA
GQLGG
T
P
ALPGQQLNAS
I
I
A
QTR
L
K
N
P
EEF
GK
V
T
L
RVNS
DG
SV
V
R
L
K
DVA
R
VE
L
G
G
E
NYNVI
A
RI
NGK
-
P
A
A
G
LG
I
K
L
AT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPF
FP
Q
G
M
K
VLYP
YDTT
PF
V
QL
SI
H
E
VVKT
L
F
EAI
M
LV
F
LV
M
YLFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
A
I
L
A
A
F
G
Y
S
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
D
KLP
P
KE
A
TE
K
SMS
QIQ
G
AL
VGIAMV
L
S
AVFIPM
A
F
FG
G
ST
G
A
IYR
Q
FSIT
IVS
AM
AL
SV
L
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWF
N
TT
F
DHSVNH
----
Y
TNSVG
K
I
L
GSTGRY
L
L
I
Y
A
L
IVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VT
DYY
LKNEKAN
V
E
SVF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
NGDENSAE
A
V
I
H
RA
KMEFGKIRDGF
V
I--
P
F
-
NMPA
I
VEL
G
TA
T
GFDFE
L
IDQAGLGH
D
A
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
L
E
VD
QE
KA
Q
A
L
GVSL
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
ML
P
ED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QG
EA
APGT
S
S
G
D
A
MALMENLASK
L
-
-
P
A
G
IGYD
W
T
G
--
MS
YQ
ER
L
SGNQAPA
L
V
A
-
I
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLM
E
KE
----------
G
KGVV
EA
TLM
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
VS
A
T
LLAI
fig|340185.4.peg.5107
Escherichia coli E22 (1-1018/1034)
M
ANFF
IRRP
IF
AWV
L
----
AI
I
L
M
M
A
G
ALA
I
LQ
LPV
A
QYP
T
I
AP
P
A
V
S
V
S
A
N
YPGA
D
AQ
T
V
Q
D
T
VT
Q
VIE
QN
M
NG
I
D
N
LM
Y
MSS
T
S
DSA
G
SVT
ITL
T
F
Q
S
GT
D
PD
I
A
QV
QVQ
NK
LQ
L
A
TPL
LP
QEVQQQ
G
I
SVE-KSSSS
---
Y
L
MVA
G
FV
S
DNPDTTQD
DI
S
D
Y
V
ASN
V
KDT
LS
RLN
GVG
D
V
QLF
G
AQY-AM
RI
W
LD
A
DL
LN
KYK
L
TPVD
V
IN
QL
KVQ
N
DQIAA
GQLGG
T
P
ALPGQQLNAS
I
I
A
QTR
L
K
N
P
EEF
GK
V
T
L
RVNS
DG
SV
V
R
L
K
DVA
R
VE
L
G
G
E
NYNVI
A
RI
NGK
-
P
A
A
G
LG
I
K
L
AT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPF
FP
Q
G
M
K
VLYP
YDTT
PF
V
QL
SI
H
E
VVKT
L
F
EAI
M
LV
F
LV
M
YLFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
A
I
L
A
A
F
G
Y
S
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
D
KLP
P
KE
A
TE
K
SMS
QIQ
G
AL
VGIAMV
L
S
AVFIPM
A
F
FG
G
ST
G
A
IYR
Q
FSIT
IVS
AM
AL
SV
L
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWF
N
TT
F
DHSVNH
----
Y
TNSVG
K
I
L
GSTGRY
L
L
I
Y
A
L
IVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VT
DYY
LKNEKAN
V
E
SVF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
NGDENSAE
A
V
I
H
RA
KMEFGKIRDGF
V
I--
P
F
-
NMPA
I
VEL
G
TA
T
GFDFE
L
IDQAGLGH
D
A
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
L
E
VD
QE
KA
Q
A
L
GVSL
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
ML
P
ED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QG
EA
APGT
S
S
G
D
A
MALMENLASK
L
-
-
P
A
G
IGYD
W
T
G
--
MS
YQ
ER
L
SGNQAPA
L
V
A
-
I
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLM
E
KE
----------
G
KGVV
EA
TLM
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
VS
A
T
LLAI
fig|562.375.peg.922
Escherichia coli EC4100B (1-1018/1034)
M
ANFF
IRRP
IF
AWV
L
----
AI
I
L
M
M
A
G
ALA
I
LQ
LPV
A
QYP
T
I
AP
P
A
V
S
V
S
A
N
YPGA
D
AQ
T
V
Q
D
T
VT
Q
VIE
QN
M
NG
I
D
N
LM
Y
MSS
T
S
DSA
G
SVT
ITL
T
F
Q
S
GT
D
PD
I
A
QV
QVQ
NK
LQ
L
A
TPL
LP
QEVQQQ
G
I
SVE-KSSSS
---
Y
L
MVA
G
FV
S
DNPDTTQD
DI
S
D
Y
V
ASN
V
KDT
LS
RLN
GVG
D
V
QLF
G
AQY-AM
RI
W
LD
A
DL
LN
KYK
L
TPVD
V
IN
QL
KVQ
N
DQIAA
GQLGG
T
P
ALPGQQLNAS
I
I
A
QTR
L
K
N
P
EEF
GK
V
T
L
RVNS
DG
SV
V
R
L
K
DVA
R
VE
L
G
G
E
NYNVI
A
RI
NGK
-
P
A
A
G
LG
I
K
L
AT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPF
FP
Q
G
M
K
VLYP
YDTT
PF
V
QL
SI
H
E
VVKT
L
F
EAI
M
LV
F
LV
M
YLFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
A
I
L
A
A
F
G
Y
S
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
D
KLP
P
KE
A
TE
K
SMS
QIQ
G
AL
VGIAMV
L
S
AVFIPM
A
F
FG
G
ST
G
A
IYR
Q
FSIT
IVS
AM
AL
SV
L
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWF
N
TT
F
DHSVNH
----
Y
TNSVG
K
I
L
GSTGRY
L
L
I
Y
A
L
IVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VT
DYY
LKNEKAN
V
E
SVF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
NGNENSAE
A
V
I
H
RA
KMEFGKIRDGF
V
I--
P
F
-
NMPA
I
VEL
G
TA
T
GFDFE
L
IDQAGLGH
D
A
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
L
E
VD
QE
KA
Q
A
L
GVSL
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
ML
P
ED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QG
EA
APGT
S
S
G
D
A
MALMENLASK
L
-
-
P
A
G
IGYD
W
T
G
--
MS
YQ
ER
L
SGNQAPA
L
V
A
-
I
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLM
E
KE
----------
G
KGVV
EA
TLM
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
VS
A
T
LLAI
fig|679205.4.peg.2758
Escherichia coli MS 124-1 (1-1018/1034)
M
ANFF
IRRP
IF
AWV
L
----
AI
I
L
M
M
A
G
ALA
I
LQ
LPV
A
QYP
T
I
AP
P
A
V
S
V
S
A
N
YPGA
D
AQ
T
V
Q
D
T
VT
Q
VIE
QN
M
NG
I
D
N
LM
Y
MSS
T
S
DSA
G
SVT
ITL
T
F
Q
S
GT
D
PD
I
A
QV
QVQ
NK
LQ
L
A
TPL
LP
QEVQQQ
G
I
SVE-KSSSS
---
Y
L
MVA
G
FV
S
DNPDTTQD
DI
S
D
Y
V
ASN
V
KDT
LS
RLN
GVG
D
V
QLF
G
AQY-AM
RI
W
LD
A
DL
LN
KYK
L
TPVD
V
IN
QL
KVQ
N
DQIAA
GQLGG
T
P
ALPGQQLNAS
I
I
A
QTR
L
K
N
P
EEF
GK
V
T
L
RVNS
DG
SV
V
R
L
K
DVA
R
VE
L
G
G
E
NYNVI
A
RI
NGK
-
P
A
A
G
LG
I
K
L
AT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPF
FP
Q
G
M
K
VLYP
YDTT
PF
V
QL
SI
H
E
VVKT
L
F
EAI
M
LV
F
LV
M
YLFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
A
I
L
A
A
F
G
Y
S
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
D
KLP
P
KE
A
TE
K
SMS
QIQ
G
AL
VGIAMV
L
S
AVFIPM
A
F
FG
G
ST
G
A
IYR
Q
FSIT
IVS
AM
AL
SV
L
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWF
N
TT
F
DHSVNH
----
Y
TNSVG
K
I
L
GSTGRY
L
L
I
Y
A
L
IVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VT
DYY
LKNEKAN
V
E
SVF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
NGDENSAE
A
V
I
H
RA
KMEFGKIRDGF
V
I--
P
F
-
NMPA
I
VEL
G
TA
T
GFDFE
L
IDQAGLGH
D
A
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
L
E
VD
QE
KA
Q
A
L
GVSL
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
ML
P
ED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QG
EA
APGT
S
S
G
D
A
MALMENLASK
L
-
-
P
A
G
IGYD
W
T
G
--
MS
YQ
ER
L
SGNQAPA
L
V
A
-
I
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLM
E
KE
----------
G
KGVV
EA
TLM
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
VS
A
T
LLAI
fig|749533.3.peg.2406
Escherichia coli MS 84-1 (1-1018/1034)
M
ANFF
IRRP
IF
AWV
L
----
AI
I
L
M
M
A
G
ALA
I
LQ
LPV
A
QYP
T
I
AP
P
A
V
S
V
S
A
N
YPGA
D
AQ
T
V
Q
D
T
VT
Q
VIE
QN
M
NG
I
D
N
LM
Y
MSS
T
S
DSA
G
SVT
ITL
T
F
Q
S
GT
D
PD
I
A
QV
QVQ
NK
LQ
L
A
TPL
LP
QEVQQQ
G
I
SVE-KSSSS
---
Y
L
MVA
G
FV
S
DNPDTTQD
DI
S
D
Y
V
ASN
V
KDT
LS
RLN
GVG
D
V
QLF
G
AQY-AM
RI
W
LD
A
DL
LN
KYK
L
TPVD
V
IN
QL
KVQ
N
DQIAA
GQLGG
T
P
ALPGQQLNAS
I
I
A
QTR
L
K
N
P
EEF
GK
V
T
L
RVNS
DG
SV
V
R
L
K
DVA
R
VE
L
G
G
E
NYNVI
A
RI
NGK
-
P
A
A
G
LG
I
K
L
AT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPF
FP
Q
G
M
K
VLYP
YDTT
PF
V
QL
SI
H
E
VVKT
L
F
EAI
M
LV
F
LV
M
YLFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
A
I
L
A
A
F
G
Y
S
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
D
KLP
P
KE
A
TE
K
SMS
QIQ
G
AL
VGIAMV
L
S
AVFIPM
A
F
FG
G
ST
G
A
IYR
Q
FSIT
IVS
AM
AL
SV
L
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWF
N
TT
F
DHSVNH
----
Y
TNSVG
K
I
L
GSTGRY
L
L
I
Y
A
L
IVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VT
DYY
LKNEKAN
V
E
SVF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
NGDENSAE
A
V
I
H
RA
KMEFGKIRDGF
V
I--
P
F
-
NMPA
I
VEL
G
TA
T
GFDFE
L
IDQAGLGH
D
A
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
L
E
VD
QE
KA
Q
A
L
GVSL
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
ML
P
ED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QG
EA
APGT
S
S
G
D
A
MALMENLASK
L
-
-
P
A
G
IGYD
W
T
G
--
MS
YQ
ER
L
SGNQAPA
L
V
A
-
I
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLM
E
KE
----------
G
KGVV
EA
TLM
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
VS
A
T
LLAI
fig|585395.4.peg.4189
Escherichia coli O103:H2 str. 12009 (1-1018/1034)
M
ANFF
IRRP
IF
AWV
L
----
AI
I
L
M
M
A
G
ALA
I
LQ
LPV
A
QYP
T
I
AP
P
A
V
S
V
S
A
N
YPGA
D
AQ
T
V
Q
D
T
VT
Q
VIE
QN
M
NG
I
D
N
LM
Y
MSS
T
S
DSA
G
SVT
ITL
T
F
Q
S
GT
D
PD
I
A
QV
QVQ
NK
LQ
L
A
TPL
LP
QEVQQQ
G
I
SVE-KSSSS
---
Y
L
MVA
G
FV
S
DNPDTTQD
DI
S
D
Y
V
ASN
V
KDT
LS
RLN
GVG
D
V
QLF
G
AQY-AM
RI
W
LD
A
DL
LN
KYK
L
TPVD
V
IN
QL
KVQ
N
DQIAA
GQLGG
T
P
ALPGQQLNAS
I
I
A
QTR
L
K
N
P
EEF
GK
V
T
L
RVNS
DG
SV
V
R
L
K
DVA
R
VE
L
G
G
E
NYNVI
A
RI
NGK
-
P
A
A
G
LG
I
K
L
AT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPF
FP
Q
G
M
K
VLYP
YDTT
PF
V
QL
SI
H
E
VVKT
L
F
EAI
M
LV
F
LV
M
YLFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
A
I
L
A
A
F
G
Y
S
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
D
KLP
P
KE
A
TE
K
SMS
QIQ
G
AL
VGIAMV
L
S
AVFIPM
A
F
FG
G
ST
G
A
IYR
Q
FSIT
IVS
AM
AL
SV
L
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWF
N
TT
F
DHSVNH
----
Y
TNSVG
K
I
L
GSTGRY
L
L
I
Y
A
L
IVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VT
DYY
LKNEKAN
V
E
SVF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
NGDENSAE
A
V
I
H
RA
KMEFGKIRDGF
V
I--
P
F
-
NMPA
I
VEL
G
TA
T
GFDFE
L
IDQAGLGH
D
A
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
L
E
VD
QE
KA
Q
A
L
GVSL
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
ML
P
ED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QG
EA
APGT
S
S
G
D
A
MALMENLASK
L
-
-
P
A
G
IGYD
W
T
G
--
MS
YQ
ER
L
SGNQAPA
L
V
A
-
I
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLM
E
KE
----------
G
KGVV
EA
TLM
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
VS
A
T
LLAI
fig|585396.4.peg.4236
Escherichia coli O111:H- str. 11128 (1-1018/1034)
M
ANFF
IRRP
IF
AWV
L
----
AI
I
L
M
M
A
G
ALA
I
LQ
LPV
A
QYP
T
I
AP
P
A
V
S
V
S
A
N
YPGA
D
AQ
T
V
Q
D
T
VT
Q
VIE
QN
M
NG
I
D
N
LM
Y
MSS
T
S
DSA
G
SVT
ITL
T
F
Q
S
GT
D
PD
I
A
QV
QVQ
NK
LQ
L
A
TPL
LP
QEVQQQ
G
I
SVE-KSSSS
---
Y
L
MVA
G
FV
S
DNPDTTQD
DI
S
D
Y
V
ASN
V
KDT
LS
RLN
GVG
D
V
QLF
G
AQY-AM
RI
W
LD
A
DL
LN
KYK
L
TPVD
V
IN
QL
KVQ
N
DQIAA
GQLGG
T
P
ALPGQQLNAS
I
I
A
QTR
L
K
N
P
EEF
GK
V
T
L
RVNS
DG
SV
V
R
L
K
DVA
R
VE
L
G
G
E
NYNVI
A
RI
NGK
-
P
A
A
G
LG
I
K
L
AT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPF
FP
Q
G
M
K
VLYP
YDTT
PF
V
QL
SI
H
E
VVKT
L
F
EAI
M
LV
F
LV
M
YLFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
A
I
L
A
A
F
G
Y
S
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
D
KLP
P
KE
A
TE
K
SMS
QIQ
G
AL
VGIAMV
L
S
AVFIPM
A
F
FG
G
ST
G
A
IYR
Q
FSIT
IVS
AM
AL
SV
L
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWF
N
TT
F
DHSVNH
----
Y
TNSVG
K
I
L
GSTGRY
L
L
I
Y
A
L
IVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VT
DYY
LKNEKAN
V
E
SVF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
NGDENSAE
A
V
I
H
RA
KMEFGKIRDGF
V
I--
P
F
-
NMPA
I
VEL
G
TA
T
GFDFE
L
IDQAGLGH
D
A
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
L
E
VD
QE
KA
Q
A
L
GVSL
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
ML
P
ED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
GS
PR
L
EHY
N
GL
P
SME
I
QG
EA
APGT
S
S
G
D
A
MALMENLASK
L
-
-
P
A
G
IGYD
W
T
G
--
MS
YQ
ER
L
SGNQAPA
L
V
A
-
I
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLM
E
KE
----------
G
KGVV
EA
TLM
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
VS
A
T
LLAI
fig|344610.3.peg.4782
Escherichia coli 53638 (1-1018/1034)
M
ANFF
IRRP
IF
AWV
L
----
AI
I
L
M
M
A
G
ALA
I
LQ
LPV
A
QYP
T
I
AP
P
A
V
S
V
S
A
N
YPGA
D
AQ
T
V
Q
D
T
VT
Q
VIE
QN
M
NG
I
D
N
LM
Y
MSS
T
S
DSA
G
SVT
ITL
T
F
Q
S
GT
D
PD
I
A
QV
QVQ
NK
LQ
L
A
TPL
LP
QEVQQQ
G
I
SVE-KSSSS
---
Y
L
MVA
G
FV
S
DNPDTTQD
DI
S
D
Y
V
ASN
V
KDT
LS
RLN
GVG
D
V
QLF
G
AQY-AM
RI
W
LD
A
DL
LN
KYK
L
TPVD
V
IN
QL
KVQ
N
DQIAA
GQLGG
T
P
ALPGQQLNAS
I
I
A
QTR
L
K
N
P
EEF
GK
V
T
L
RVNS
DG
SV
V
R
L
K
DVA
R
VE
L
G
G
E
NYNVI
A
RI
NGK
-
P
A
A
G
LG
I
K
L
AT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPF
FP
Q
G
M
K
VLYP
YDTT
PF
V
QL
SI
H
E
VVKT
L
F
EAI
M
LV
F
LV
M
YLFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
A
I
L
A
A
F
G
Y
S
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
D
KLP
P
KE
A
TE
K
SMS
QIQ
G
AL
VGIAMV
L
S
AVFIPM
A
F
FG
G
ST
G
A
IYR
Q
FSIT
IVS
AM
AL
SV
L
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWF
N
TT
F
DHSVNH
----
Y
TNSVG
K
I
L
GSTGRY
L
L
I
Y
A
L
IVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VT
DYY
LKNEKAN
V
E
SVF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
SGDENSAE
A
V
I
H
RA
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VEL
G
TA
T
GFDFE
L
IDQAGLGH
D
A
L
TQARN
QL
LGM
A
AQH
P
AS
L
VN
V
RP
N
G
LE
DTAQFK
L
E
VD
QE
KA
Q
A
L
GVSL
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
ML
P
ED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QG
EA
APGT
S
S
G
D
A
MALMENLASK
L
-
-
P
A
G
IGYD
W
T
G
--
MS
YQ
ER
L
SGNQAPA
L
V
A
-
I
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLM
E
KE
----------
G
KGVV
EA
TLM
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
VS
A
T
LLAI
fig|431946.3.peg.3234
Escherichia coli SE15 (1-1018/1034)
M
ANFF
IRRP
IF
AWV
L
----
AI
I
L
M
M
A
G
ALA
I
LQ
LPV
A
QYP
T
I
AP
P
A
V
S
V
S
A
N
YPGA
D
AQ
T
V
Q
D
T
VT
Q
VIE
QN
M
NG
I
D
N
LM
Y
MSS
T
S
DSA
G
SVT
ITL
T
F
Q
S
GT
D
PD
I
A
QV
QVQ
NK
LQ
L
A
TPL
LP
QEVQQQ
G
I
SVE-KSSSS
---
Y
L
MVA
G
FV
S
DNPGTTQD
DI
S
D
Y
V
ASN
V
KDT
LS
RLN
GVG
D
V
QLF
G
AQY-AM
RI
W
LD
A
DL
LN
KYK
L
TPVD
V
IN
QL
KVQ
N
DQIAA
GQLGG
T
P
ALPGQQLNAS
I
I
A
QTR
L
K
N
P
EEF
GK
V
T
L
RVNS
DG
SV
V
R
L
K
DVA
R
VE
L
G
G
E
NYNVI
A
RI
NGK
-
P
A
A
G
LG
I
K
L
AT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPF
FP
Q
G
M
K
VLYP
YDTT
PF
V
QL
SI
Q
E
VVKT
L
F
EAI
M
LV
F
LV
M
YLFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
A
I
L
A
A
F
G
Y
S
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
D
KLP
P
RE
A
TE
K
SMS
QIQ
G
AL
VGIAMV
L
S
AVFIPM
A
F
FG
G
ST
G
A
IYR
Q
FSIT
IVS
AM
AL
SV
L
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWF
N
TT
F
DHSVNH
----
Y
TNSVG
K
I
L
GSTGRY
L
L
I
Y
A
L
IVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VT
DYY
LKNEKAN
V
E
SVF
TVN
G
FSFSGQEQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
SGDENSAE
A
V
I
H
RA
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VEL
G
TA
T
GFDFE
L
IDQAGLGH
D
A
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
L
E
VD
QE
KA
Q
A
L
GVSL
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
ML
P
ED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QG
EA
APGT
S
S
G
D
A
MALMENLASK
L
-
-
P
A
G
IGYD
W
T
G
--
MS
YQ
ER
L
SGNQAPA
L
V
A
-
I
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLM
E
KE
----------
G
KGVV
EA
TLM
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
VS
A
T
LLAI
fig|316401.4.peg.4000
Escherichia coli ETEC H10407 (1-1018/1034)
M
ANFF
IRRP
IF
AWV
L
----
AI
I
L
M
M
A
G
ALA
I
LQ
LPV
A
QYP
T
I
AP
P
A
V
S
V
S
A
N
YPGA
D
AQ
T
V
Q
D
T
VT
Q
VIE
QN
M
NG
I
D
N
LM
Y
MSS
T
S
DSA
G
SVT
ITL
T
F
Q
S
GT
D
PD
I
A
QV
QVQ
NK
LQ
L
A
TPL
LP
QEVQQQ
G
I
SVE-KSSSS
---
Y
L
MVA
G
FV
S
DNPGTTQD
DI
S
D
Y
V
ASN
V
KDT
LS
RLN
GVG
D
V
QLF
G
AQY-AM
RI
W
LD
A
DL
LN
KYK
L
TPVD
V
IN
QL
KVQ
N
DQIAA
GQLGG
T
P
ALPGQQLNAS
I
I
A
QTR
F
K
N
P
EEF
GK
V
T
L
RVNS
DG
SV
V
R
L
K
DVA
R
VE
L
G
G
E
NYNVI
A
RI
NGK
-
P
A
A
G
LG
I
K
L
AT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPF
FP
Q
G
M
K
VLYP
YDTT
PF
V
QL
SI
H
E
VVKT
L
F
EAI
M
LV
F
LV
M
YLFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
A
I
L
A
A
F
G
Y
S
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
D
KLP
P
KE
A
TE
K
SMS
QIQ
G
AL
VGIAMV
L
S
AVFIPM
A
F
FG
G
ST
G
A
IYR
Q
FSIT
IVS
AM
AL
SV
L
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWF
N
TT
F
DHSVNH
----
Y
TNSVG
K
I
L
GSTGRY
L
L
I
Y
A
L
IVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VT
DYY
LKNEKAN
V
E
SVF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
NGDENSAE
A
V
I
H
RA
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VEL
G
TA
T
GFDFE
L
IDQAGLGH
D
A
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
L
E
VD
QE
KA
Q
A
L
GVSL
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
ML
P
ED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QG
EA
APGT
S
S
G
D
A
MALMENLASK
L
-
-
P
A
G
IGYD
W
T
G
--
MS
YQ
ER
L
SGNQAPA
L
V
A
-
I
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
IS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLM
E
KE
----------
G
KGVV
EA
TLM
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
VS
A
T
LLAI
fig|749527.3.peg.2193
Escherichia coli MS 21-1 (1-1018/1034)
M
ANFF
IRRP
IF
AWV
L
----
AI
I
L
M
M
A
G
ALA
I
LQ
LPV
A
QYP
T
I
AP
P
A
V
S
V
S
A
N
YPGA
D
AQ
T
V
Q
D
T
VT
Q
VIE
QN
M
NG
I
D
N
LM
Y
MSS
T
S
DSA
G
SVT
ITL
T
F
Q
S
GT
D
PD
I
A
QV
QVQ
NK
LQ
L
A
TPL
LP
QEVQQQ
G
I
SVE-KSSSS
---
Y
L
MVA
G
FV
S
DNPGTTQD
DI
S
D
Y
V
ASN
V
KDT
LS
RLN
GVG
D
V
QLF
G
AQY-AM
RI
W
LD
A
DL
LN
KYK
L
TPVD
V
IN
QL
KVQ
N
DQIAA
GQLGG
T
P
ALPGQQLNAS
I
I
A
QTR
L
K
N
P
EEF
GK
V
T
L
RVNS
DG
SV
V
R
L
K
DVA
R
VE
L
G
G
E
NYNVI
A
RI
N
D
K
-
P
A
A
G
LG
I
K
L
AT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPF
FP
Q
G
M
K
VLYP
YDTT
PF
V
QL
SI
H
E
VVKT
L
F
EAI
M
LV
F
LV
M
YLFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
A
I
L
A
A
F
G
Y
S
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
D
KLP
P
KE
A
TE
K
SMS
QIQ
G
AL
VGIAMV
L
S
AVFIPM
A
F
FG
G
ST
G
A
IYR
Q
FSIT
IVS
AM
AL
SV
L
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWV
N
TT
F
DHSVNH
----
Y
TNSVG
K
I
L
GSTGRY
L
L
I
Y
A
L
IVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VT
DYY
LKNEKAN
V
E
SVF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
SGDENSAE
A
V
I
H
RA
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VEL
G
TA
T
GFDFE
L
IDQAGLGH
D
A
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
L
E
VD
QE
KA
Q
A
L
GVSL
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
ML
P
ED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TAHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QG
EA
APGT
S
S
G
D
A
MALMENIASK
L
-
-
P
A
G
IGYD
W
T
G
--
MS
YQ
ER
L
SGNQAPA
L
V
A
-
I
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLM
E
KE
----------
G
KGVV
EA
TLM
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
VS
A
T
LLAI
fig|585055.8.peg.3721
Escherichia coli 55989 (1-1018/1034)
M
ANFF
IRRP
IF
AWV
L
----
AI
I
L
M
M
A
G
ALA
I
LQ
LPV
A
QYP
T
I
AP
P
A
V
S
V
S
A
N
YPGA
D
AQ
T
V
Q
D
T
VT
Q
VIE
QN
M
NG
I
D
N
LM
Y
MSS
T
S
DSA
G
SVT
ITL
T
F
Q
S
GT
D
PD
I
A
QV
QVQ
NK
LQ
L
A
TPL
LP
QEVQQQ
G
I
SVE-KSSSS
---
Y
L
MVA
G
FV
S
DNPDTTQD
DI
S
D
Y
V
ASN
V
KDT
LS
RLN
GVG
D
V
QLF
G
AQY-AM
RI
W
LD
A
DL
LN
KYK
L
TPVD
V
IN
QL
KVQ
N
DQIAA
GQLGG
T
P
ALPGQQLNAS
I
I
A
QTR
L
K
N
P
EEF
GK
V
T
L
RVNS
DG
SV
V
R
L
K
DVA
R
VE
L
G
G
E
NYNVI
A
RI
NGK
-
P
A
A
G
LG
I
K
L
AT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPF
FP
Q
G
M
K
VLYP
YDTT
PF
V
QL
SI
H
E
VVKT
L
F
EAI
M
LV
F
LV
M
YLFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
A
I
L
A
A
F
G
Y
S
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
D
KLP
P
KE
A
TE
K
SMS
QIQ
G
AL
VGIAMV
L
S
AVFIPM
A
F
FG
G
ST
G
A
IYR
Q
FSIT
IVS
AM
AL
SV
L
VAL
I
LTP
A
LCA
TL
L
KPTSAEHHENKGGFFGWF
N
TT
F
DHSVNH
----
Y
TNSVG
K
I
L
GSTGRY
L
L
I
Y
A
L
IVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VT
DYY
LKNEKAN
V
E
SVF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
NSDENSAE
A
V
I
H
RA
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VEL
G
TA
T
GFDFE
L
IDQAGLGH
D
A
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
L
E
VD
QE
KA
Q
A
L
GVSL
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
ML
P
ED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QG
EA
APGT
S
S
G
D
A
MALMENLASK
L
-
-
P
A
G
IGYD
W
T
G
--
MS
YQ
ER
L
SGNQAPA
L
V
A
-
I
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLM
E
KE
----------
G
KGVV
EA
TLM
A
VRM
R
L
H
PILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
VS
A
T
LLAI
fig|344601.5.peg.4834
Escherichia coli B171 (1-1005/1021)
M
L
----
AI
I
L
M
M
A
G
ALA
I
LQ
LPV
A
QYP
T
I
AP
P
A
V
S
V
S
A
N
YPGA
D
AQ
T
V
Q
D
T
VT
Q
VIE
QN
M
NG
I
D
N
LM
Y
MSS
T
S
DSA
G
SVT
ITL
T
F
Q
S
GT
D
PD
I
A
QV
QVQ
NK
LQ
L
A
TPL
LP
QEVQQQ
G
I
SVE-KSSSS
---
Y
L
MVA
G
FV
S
DNPDTTQD
DI
S
D
Y
V
ASN
V
KDT
LS
RLN
GVG
D
V
QLF
G
AQY-AM
RI
W
LD
A
DL
LN
KYK
L
TPVD
V
IN
QL
KVQ
N
DQIAA
GQLGG
T
P
ALPGQQLNAS
I
I
A
QTR
L
K
N
P
EEF
GK
V
T
L
RVNS
DG
SV
V
R
L
K
DVA
R
VE
L
G
G
E
NYNVI
A
RI
NGK
-
P
A
A
G
LG
I
K
L
AT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPF
FP
Q
G
M
K
VLYP
YDTT
PF
V
QL
SI
H
E
VVKT
L
F
EAI
M
LV
F
LV
M
YLFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
A
I
L
A
A
F
G
Y
S
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
D
KLP
P
KE
A
TE
K
SMS
QIQ
G
AL
VGIAMV
L
S
AVFIPM
A
F
FG
G
ST
G
A
IYR
Q
FSIT
IVS
AM
AL
SV
L
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWF
N
TT
F
DHSVNH
----
Y
TNSVG
K
I
L
GSTGRY
L
L
I
Y
A
L
IVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VT
DYY
LKNEKAN
V
E
SVF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
NGDENSAE
A
V
I
H
RA
KMEFGKIRDGF
V
I--
P
F
-
NMPA
I
VEL
G
TA
T
GFDFE
L
IDQAGLGH
D
A
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
L
E
VD
QE
KA
Q
A
L
GVSL
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
ML
P
ED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QG
EA
APGT
S
S
G
D
A
MALMENLASK
L
-
-
P
A
G
IGYD
W
T
G
--
MS
YQ
ER
L
SGNQAPA
L
V
A
-
I
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLM
E
KE
----------
G
KGVV
EA
TLM
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
VS
A
T
LLAI
fig|573235.3.peg.4477
Escherichia coli O26:H11 str. 11368 (1-1005/1021)
M
L
----
AI
I
L
M
M
A
G
ALA
I
LQ
LPV
A
QYP
T
I
AP
P
A
V
S
V
S
A
N
YPGA
D
AQ
T
V
Q
D
T
VT
Q
VIE
QN
M
NG
I
D
N
LM
Y
MSS
T
S
DSA
G
SVT
ITL
T
F
Q
S
GT
D
PD
I
A
QV
QVQ
NK
LQ
L
A
TPL
LP
QEVQQQ
G
I
SVE-KSSSS
---
Y
L
MVA
G
FV
S
DNPDTTQD
DI
S
D
Y
V
ASN
V
KDT
LS
RLN
GVG
D
V
QLF
G
AQY-AM
RI
W
LD
A
DL
LN
KYK
L
TPVD
V
IN
QL
KVQ
N
DQIAA
GQLGG
T
P
ALPGQQLNAS
I
I
A
QTR
L
K
N
P
EEF
GK
V
T
L
RVNS
DG
SV
V
R
L
K
DVA
R
VE
L
G
G
E
NYNVI
A
RI
NGK
-
P
A
A
G
LG
I
K
L
AT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPF
FP
Q
G
M
K
VLYP
YDTT
PF
V
QL
SI
H
E
VVKT
L
F
EAI
M
LV
F
LV
M
YLFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
A
I
L
A
A
F
G
Y
S
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
D
KLP
P
KE
A
TE
K
SMS
QIQ
G
AL
VGIAMV
L
S
AVFIPM
A
F
FG
G
ST
G
A
IYR
Q
FSIT
IVS
AM
AL
SV
L
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWF
N
TT
F
DHSVNH
----
Y
TNSVG
K
I
L
GSTGRY
L
L
I
Y
A
L
IVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VT
DYY
LKNEKAN
V
E
SVF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
NGDENSAE
A
V
I
H
RA
KMEFGKIRDGF
V
I--
P
F
-
NMPA
I
VEL
G
TA
T
GFDFE
L
IDQAGLGH
D
A
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
L
E
VD
QE
KA
Q
A
L
GVSL
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
ML
P
ED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QG
EA
APGT
S
S
G
D
A
MALMENLASK
L
-
-
P
A
G
IGYD
W
T
G
--
MS
YQ
ER
L
SGNQAPA
L
V
A
-
I
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLM
E
KE
----------
G
KGVV
EA
TLM
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
VS
A
T
LLAI
fig|536056.3.peg.460
Escherichia coli DH1 (1-1018/1034)
M
ANFF
IRRP
IF
AWV
L
----
AI
I
L
M
M
A
G
ALA
I
LQ
LPV
A
QYP
T
I
AP
P
A
V
S
V
S
A
N
YPGA
D
AQ
T
V
Q
D
T
VT
Q
VIE
QN
M
NG
I
D
N
LM
Y
MSS
T
S
DSA
G
SVT
ITL
T
F
Q
S
GT
D
PD
I
A
QV
QVQ
NK
LQ
L
A
TPL
LP
QEVQQQ
G
I
SVE-KSSSS
---
Y
L
MVA
G
FV
S
DNPGTTQD
DI
S
D
Y
V
ASN
V
KDT
LS
RLN
GVG
D
V
QLF
G
AQY-AM
RI
W
LD
A
DL
LN
KYK
L
TPVD
V
IN
QL
KVQ
N
DQIAA
GQLGG
T
P
ALPGQQLNAS
I
I
A
QTR
F
K
N
P
EEF
GK
V
T
L
RVNS
DG
SV
V
R
L
K
DVA
R
VE
L
G
G
E
NYNVI
A
RI
NGK
-
P
A
A
G
LG
I
K
L
AT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPF
FP
Q
G
M
K
VLYP
YDTT
PF
V
QL
SI
H
E
VVKT
L
F
EAI
M
LV
F
LV
M
YLFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
A
I
L
A
A
F
G
Y
S
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
D
KLP
P
KE
A
TE
K
SMS
QIQ
G
AL
VGIAMV
L
S
AVFIPM
A
F
FG
G
ST
G
A
IYR
Q
FSIT
IVS
AM
AL
SV
L
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWF
N
TT
F
DHSVNH
----
Y
TNSVG
K
I
L
GSTGRY
L
L
I
Y
A
L
IVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VT
DYY
LKNEKAN
V
E
SVF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
NGDENSAE
A
V
I
H
RA
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VEL
G
TA
T
GFDFE
L
IDQAGLGH
D
A
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
L
E
VD
QE
KA
Q
A
L
GVSL
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
L
Y
VQ
ADAKF
R
ML
P
ED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QG
EA
APGT
S
S
G
D
A
MALMENLASK
L
-
-
P
A
G
IGYD
W
T
G
--
MS
YQ
ER
L
SGNQAPA
L
V
A
-
I
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLM
E
KE
----------
G
KGVV
EA
TLM
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
VS
A
T
LLAI
fig|83333.1.peg.3208
Escherichia coli K12 (1-1018/1034)
M
ANFF
IRRP
IF
AWV
L
----
AI
I
L
M
M
A
G
ALA
I
LQ
LPV
A
QYP
T
I
AP
P
A
V
S
V
S
A
N
YPGA
D
AQ
T
V
Q
D
T
VT
Q
VIE
QN
M
NG
I
D
N
LM
Y
MSS
T
S
DSA
G
SVT
ITL
T
F
Q
S
GT
D
PD
I
A
QV
QVQ
NK
LQ
L
A
TPL
LP
QEVQQQ
G
I
SVE-KSSSS
---
Y
L
MVA
G
FV
S
DNPGTTQD
DI
S
D
Y
V
ASN
V
KDT
LS
RLN
GVG
D
V
QLF
G
AQY-AM
RI
W
LD
A
DL
LN
KYK
L
TPVD
V
IN
QL
KVQ
N
DQIAA
GQLGG
T
P
ALPGQQLNAS
I
I
A
QTR
F
K
N
P
EEF
GK
V
T
L
RVNS
DG
SV
V
R
L
K
DVA
R
VE
L
G
G
E
NYNVI
A
RI
NGK
-
P
A
A
G
LG
I
K
L
AT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPF
FP
Q
G
M
K
VLYP
YDTT
PF
V
QL
SI
H
E
VVKT
L
F
EAI
M
LV
F
LV
M
YLFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
A
I
L
A
A
F
G
Y
S
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
D
KLP
P
KE
A
TE
K
SMS
QIQ
G
AL
VGIAMV
L
S
AVFIPM
A
F
FG
G
ST
G
A
IYR
Q
FSIT
IVS
AM
AL
SV
L
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWF
N
TT
F
DHSVNH
----
Y
TNSVG
K
I
L
GSTGRY
L
L
I
Y
A
L
IVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VT
DYY
LKNEKAN
V
E
SVF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
NGDENSAE
A
V
I
H
RA
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VEL
G
TA
T
GFDFE
L
IDQAGLGH
D
A
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
L
E
VD
QE
KA
Q
A
L
GVSL
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
L
Y
VQ
ADAKF
R
ML
P
ED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QG
EA
APGT
S
S
G
D
A
MALMENLASK
L
-
-
P
A
G
IGYD
W
T
G
--
MS
YQ
ER
L
SGNQAPA
L
V
A
-
I
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLM
E
KE
----------
G
KGVV
EA
TLM
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
VS
A
T
LLAI
fig|749538.3.peg.530
Escherichia coli MS 116-1 (1-1018/1034)
M
ANFF
IRRP
IF
AWV
L
----
AI
I
L
M
M
A
G
ALA
I
LQ
LPV
A
QYP
T
I
AP
P
A
V
S
V
S
A
N
YPGA
D
AQ
T
V
Q
D
T
VT
Q
VIE
QN
M
NG
I
D
N
LM
Y
MSS
T
S
DSA
G
SVT
ITL
T
F
Q
S
GT
D
PD
I
A
QV
QVQ
NK
LQ
L
A
TPL
LP
QEVQQQ
G
I
SVE-KSSSS
---
Y
L
MVA
G
FV
S
DNPGTTQD
DI
S
D
Y
V
ASN
V
KDT
LS
RLN
GVG
D
V
QLF
G
AQY-AM
RI
W
LD
A
DL
LN
KYK
L
TPVD
V
IN
QL
KVQ
N
DQIAA
GQLGG
T
P
ALPGQQLNAS
I
I
A
QTR
F
K
N
P
EEF
GK
V
T
L
RVNS
DG
SV
V
R
L
K
DVA
R
VE
L
G
G
E
NYNVI
A
RI
NGK
-
P
A
A
G
LG
I
K
L
AT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPF
FP
Q
G
M
K
VLYP
YDTT
PF
V
QL
SI
H
E
VVKT
L
F
EAI
M
LV
F
LV
M
YLFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
A
I
L
A
A
F
G
Y
S
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
D
KLP
P
KE
A
TE
K
SMS
QIQ
G
AL
VGIAMV
L
S
AVFIPM
A
F
FG
G
ST
G
A
IYR
Q
FSIT
IVS
AM
AL
SV
L
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWF
N
TT
F
DHSVNH
----
Y
TNSVG
K
I
L
GSTGRY
L
L
I
Y
A
L
IVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VT
DYY
LKNEKAN
V
E
SVF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
NGDENSAE
A
V
I
H
RA
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VEL
G
TA
T
GFDFE
L
IDQAGLGH
D
A
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
L
E
VD
QE
KA
Q
A
L
GVSL
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
L
Y
VQ
ADAKF
R
ML
P
ED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QG
EA
APGT
S
S
G
D
A
MALMENLASK
L
-
-
P
A
G
IGYD
W
T
G
--
MS
YQ
ER
L
SGNQAPA
L
V
A
-
I
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLM
E
KE
----------
G
KGVV
EA
TLM
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
VS
A
T
LLAI
fig|749548.3.peg.3972
Escherichia coli MS 196-1 (1-1018/1034)
M
ANFF
IRRP
IF
AWV
L
----
AI
I
L
M
M
A
G
ALA
I
LQ
LPV
A
QYP
T
I
AP
P
A
V
S
V
S
A
N
YPGA
D
AQ
T
V
Q
D
T
VT
Q
VIE
QN
M
NG
I
D
N
LM
Y
MSS
T
S
DSA
G
SVT
ITL
T
F
Q
S
GT
D
PD
I
A
QV
QVQ
NK
LQ
L
A
TPL
LP
QEVQQQ
G
I
SVE-KSSSS
---
Y
L
MVA
G
FV
S
DNPGTTQD
DI
S
D
Y
V
ASN
V
KDT
LS
RLN
GVG
D
V
QLF
G
AQY-AM
RI
W
LD
A
DL
LN
KYK
L
TPVD
V
IN
QL
KVQ
N
DQIAA
GQLGG
T
P
ALPGQQLNAS
I
I
A
QTR
F
K
N
P
EEF
GK
V
T
L
RVNS
DG
SV
V
R
L
K
DVA
R
VE
L
G
G
E
NYNVI
A
RI
NGK
-
P
A
A
G
LG
I
K
L
AT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPF
FP
Q
G
M
K
VLYP
YDTT
PF
V
QL
SI
H
E
VVKT
L
F
EAI
M
LV
F
LV
M
YLFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
A
I
L
A
A
F
G
Y
S
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
D
KLP
P
KE
A
TE
K
SMS
QIQ
G
AL
VGIAMV
L
S
AVFIPM
A
F
FG
G
ST
G
A
IYR
Q
FSIT
IVS
AM
AL
SV
L
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWF
N
TT
F
DHSVNH
----
Y
TNSVG
K
I
L
GSTGRY
L
L
I
Y
A
L
IVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VT
DYY
LKNEKAN
V
E
SVF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
NGDENSAE
A
V
I
H
RA
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VEL
G
TA
T
GFDFE
L
IDQAGLGH
D
A
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
L
E
VD
QE
KA
Q
A
L
GVSL
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
L
Y
VQ
ADAKF
R
ML
P
ED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QG
EA
APGT
S
S
G
D
A
MALMENLASK
L
-
-
P
A
G
IGYD
W
T
G
--
MS
YQ
ER
L
SGNQAPA
L
V
A
-
I
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLM
E
KE
----------
G
KGVV
EA
TLM
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
VS
A
T
LLAI
fig|316407.3.peg.3142
Escherichia coli W3110 (1-1018/1034)
M
ANFF
IRRP
IF
AWV
L
----
AI
I
L
M
M
A
G
ALA
I
LQ
LPV
A
QYP
T
I
AP
P
A
V
S
V
S
A
N
YPGA
D
AQ
T
V
Q
D
T
VT
Q
VIE
QN
M
NG
I
D
N
LM
Y
MSS
T
S
DSA
G
SVT
ITL
T
F
Q
S
GT
D
PD
I
A
QV
QVQ
NK
LQ
L
A
TPL
LP
QEVQQQ
G
I
SVE-KSSSS
---
Y
L
MVA
G
FV
S
DNPGTTQD
DI
S
D
Y
V
ASN
V
KDT
LS
RLN
GVG
D
V
QLF
G
AQY-AM
RI
W
LD
A
DL
LN
KYK
L
TPVD
V
IN
QL
KVQ
N
DQIAA
GQLGG
T
P
ALPGQQLNAS
I
I
A
QTR
F
K
N
P
EEF
GK
V
T
L
RVNS
DG
SV
V
R
L
K
DVA
R
VE
L
G
G
E
NYNVI
A
RI
NGK
-
P
A
A
G
LG
I
K
L
AT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPF
FP
Q
G
M
K
VLYP
YDTT
PF
V
QL
SI
H
E
VVKT
L
F
EAI
M
LV
F
LV
M
YLFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
A
I
L
A
A
F
G
Y
S
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
D
KLP
P
KE
A
TE
K
SMS
QIQ
G
AL
VGIAMV
L
S
AVFIPM
A
F
FG
G
ST
G
A
IYR
Q
FSIT
IVS
AM
AL
SV
L
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWF
N
TT
F
DHSVNH
----
Y
TNSVG
K
I
L
GSTGRY
L
L
I
Y
A
L
IVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VT
DYY
LKNEKAN
V
E
SVF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
NGDENSAE
A
V
I
H
RA
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VEL
G
TA
T
GFDFE
L
IDQAGLGH
D
A
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
L
E
VD
QE
KA
Q
A
L
GVSL
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
L
Y
VQ
ADAKF
R
ML
P
ED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QG
EA
APGT
S
S
G
D
A
MALMENLASK
L
-
-
P
A
G
IGYD
W
T
G
--
MS
YQ
ER
L
SGNQAPA
L
V
A
-
I
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLM
E
KE
----------
G
KGVV
EA
TLM
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
VS
A
T
LLAI
fig|316385.5.peg.3394
Escherichia coli str. K-12 substr. DH10B (1-1018/1034)
M
ANFF
IRRP
IF
AWV
L
----
AI
I
L
M
M
A
G
ALA
I
LQ
LPV
A
QYP
T
I
AP
P
A
V
S
V
S
A
N
YPGA
D
AQ
T
V
Q
D
T
VT
Q
VIE
QN
M
NG
I
D
N
LM
Y
MSS
T
S
DSA
G
SVT
ITL
T
F
Q
S
GT
D
PD
I
A
QV
QVQ
NK
LQ
L
A
TPL
LP
QEVQQQ
G
I
SVE-KSSSS
---
Y
L
MVA
G
FV
S
DNPGTTQD
DI
S
D
Y
V
ASN
V
KDT
LS
RLN
GVG
D
V
QLF
G
AQY-AM
RI
W
LD
A
DL
LN
KYK
L
TPVD
V
IN
QL
KVQ
N
DQIAA
GQLGG
T
P
ALPGQQLNAS
I
I
A
QTR
F
K
N
P
EEF
GK
V
T
L
RVNS
DG
SV
V
R
L
K
DVA
R
VE
L
G
G
E
NYNVI
A
RI
NGK
-
P
A
A
G
LG
I
K
L
AT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPF
FP
Q
G
M
K
VLYP
YDTT
PF
V
QL
SI
H
E
VVKT
L
F
EAI
M
LV
F
LV
M
YLFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
A
I
L
A
A
F
G
Y
S
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
D
KLP
P
KE
A
TE
K
SMS
QIQ
G
AL
VGIAMV
L
S
AVFIPM
A
F
FG
G
ST
G
A
IYR
Q
FSIT
IVS
AM
AL
SV
L
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWF
N
TT
F
DHSVNH
----
Y
TNSVG
K
I
L
GSTGRY
L
L
I
Y
A
L
IVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VT
DYY
LKNEKAN
V
E
SVF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
NGDENSAE
A
V
I
H
RA
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VEL
G
TA
T
GFDFE
L
IDQAGLGH
D
A
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
L
E
VD
QE
KA
Q
A
L
GVSL
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
L
Y
VQ
ADAKF
R
ML
P
ED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QG
EA
APGT
S
S
G
D
A
MALMENLASK
L
-
-
P
A
G
IGYD
W
T
G
--
MS
YQ
ER
L
SGNQAPA
L
V
A
-
I
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLM
E
KE
----------
G
KGVV
EA
TLM
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
VS
A
T
LLAI
fig|511145.6.peg.3349
Escherichia coli str. K-12 substr. MG1655 (1-1018/1034)
M
ANFF
IRRP
IF
AWV
L
----
AI
I
L
M
M
A
G
ALA
I
LQ
LPV
A
QYP
T
I
AP
P
A
V
S
V
S
A
N
YPGA
D
AQ
T
V
Q
D
T
VT
Q
VIE
QN
M
NG
I
D
N
LM
Y
MSS
T
S
DSA
G
SVT
ITL
T
F
Q
S
GT
D
PD
I
A
QV
QVQ
NK
LQ
L
A
TPL
LP
QEVQQQ
G
I
SVE-KSSSS
---
Y
L
MVA
G
FV
S
DNPGTTQD
DI
S
D
Y
V
ASN
V
KDT
LS
RLN
GVG
D
V
QLF
G
AQY-AM
RI
W
LD
A
DL
LN
KYK
L
TPVD
V
IN
QL
KVQ
N
DQIAA
GQLGG
T
P
ALPGQQLNAS
I
I
A
QTR
F
K
N
P
EEF
GK
V
T
L
RVNS
DG
SV
V
R
L
K
DVA
R
VE
L
G
G
E
NYNVI
A
RI
NGK
-
P
A
A
G
LG
I
K
L
AT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPF
FP
Q
G
M
K
VLYP
YDTT
PF
V
QL
SI
H
E
VVKT
L
F
EAI
M
LV
F
LV
M
YLFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
A
I
L
A
A
F
G
Y
S
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
D
KLP
P
KE
A
TE
K
SMS
QIQ
G
AL
VGIAMV
L
S
AVFIPM
A
F
FG
G
ST
G
A
IYR
Q
FSIT
IVS
AM
AL
SV
L
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWF
N
TT
F
DHSVNH
----
Y
TNSVG
K
I
L
GSTGRY
L
L
I
Y
A
L
IVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VT
DYY
LKNEKAN
V
E
SVF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
NGDENSAE
A
V
I
H
RA
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VEL
G
TA
T
GFDFE
L
IDQAGLGH
D
A
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
L
E
VD
QE
KA
Q
A
L
GVSL
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
L
Y
VQ
ADAKF
R
ML
P
ED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QG
EA
APGT
S
S
G
D
A
MALMENLASK
L
-
-
P
A
G
IGYD
W
T
G
--
MS
YQ
ER
L
SGNQAPA
L
V
A
-
I
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLM
E
KE
----------
G
KGVV
EA
TLM
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
VS
A
T
LLAI
fig|344610.7.peg.2970
Escherichia coli 53638 (1-1005/1021)
M
L
----
AI
I
L
M
M
A
G
ALA
I
LQ
LPV
A
QYP
T
I
AP
P
A
V
S
V
S
A
N
YPGA
D
AQ
T
V
Q
D
T
VT
Q
VIE
QN
M
NG
I
D
N
LM
Y
MSS
T
S
DSA
G
SVT
ITL
T
F
Q
S
GT
D
PD
I
A
QV
QVQ
NK
LQ
L
A
TPL
LP
QEVQQQ
G
I
SVE-KSSSS
---
Y
L
MVA
G
FV
S
DNPDTTQD
DI
S
D
Y
V
ASN
V
KDT
LS
RLN
GVG
D
V
QLF
G
AQY-AM
RI
W
LD
A
DL
LN
KYK
L
TPVD
V
IN
QL
KVQ
N
DQIAA
GQLGG
T
P
ALPGQQLNAS
I
I
A
QTR
L
K
N
P
EEF
GK
V
T
L
RVNS
DG
SV
V
R
L
K
DVA
R
VE
L
G
G
E
NYNVI
A
RI
NGK
-
P
A
A
G
LG
I
K
L
AT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPF
FP
Q
G
M
K
VLYP
YDTT
PF
V
QL
SI
H
E
VVKT
L
F
EAI
M
LV
F
LV
M
YLFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
A
I
L
A
A
F
G
Y
S
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
D
KLP
P
KE
A
TE
K
SMS
QIQ
G
AL
VGIAMV
L
S
AVFIPM
A
F
FG
G
ST
G
A
IYR
Q
FSIT
IVS
AM
AL
SV
L
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWF
N
TT
F
DHSVNH
----
Y
TNSVG
K
I
L
GSTGRY
L
L
I
Y
A
L
IVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VT
DYY
LKNEKAN
V
E
SVF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
SGDENSAE
A
V
I
H
RA
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VEL
G
TA
T
GFDFE
L
IDQAGLGH
D
A
L
TQARN
QL
LGM
A
AQH
P
AS
L
VN
V
RP
N
G
LE
DTAQFK
L
E
VD
QE
KA
Q
A
L
GVSL
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
ML
P
ED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QG
EA
APGT
S
S
G
D
A
MALMENLASK
L
-
-
P
A
G
IGYD
W
T
G
--
MS
YQ
ER
L
SGNQAPA
L
V
A
-
I
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLM
E
KE
----------
G
KGVV
EA
TLM
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
VS
A
T
LLAI
fig|481805.3.peg.466
Escherichia coli ATCC 8739 (1-1018/1034)
M
ANFF
IRRP
IF
AWV
L
----
AI
I
L
M
M
A
G
ALA
I
LQ
LPV
A
QYP
T
I
AP
P
A
V
S
V
S
A
N
YPGA
D
AQ
T
V
Q
D
T
VT
Q
VIE
QN
M
NG
I
D
N
LM
Y
MSS
T
S
DSA
G
SVT
ITL
T
F
Q
S
GT
D
PD
I
A
QV
QVQ
NK
LQ
L
A
TPL
LP
QEVQQQ
G
I
SVE-KSSSS
---
Y
L
MVA
G
FV
S
DNPDTTQD
DI
S
D
Y
V
ASN
V
KDT
LS
RLN
GVG
D
V
QLF
G
AQY-AM
RI
W
LD
A
DL
LN
KYK
L
TPVD
V
IN
QL
KVQ
N
DQIAA
GQLGG
T
P
ALPGQQLNAS
I
I
A
QTR
L
K
N
P
EEF
GK
V
T
L
RVNS
DG
SV
V
R
L
K
DVA
R
VE
L
G
G
E
NYNVI
A
RI
NGK
-
P
A
A
G
LG
I
K
L
AT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPF
FP
Q
G
M
K
VLYP
YDTT
PF
V
QL
SI
H
E
VVKT
L
F
EAI
M
LV
F
LV
M
YLFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
A
I
L
A
A
F
G
Y
S
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVE
K
VE
R
V
M
M
E
----------
D
KLP
P
KE
A
TE
K
SMS
QIQ
G
AL
VGIAMV
L
S
AVFIPM
A
F
FG
G
ST
G
A
IYR
Q
FSIT
IVS
AM
AL
SV
L
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWF
N
TT
F
DHSVNH
----
Y
TNSVG
K
I
L
GSTGRY
L
L
I
Y
A
L
IVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VT
DYY
LKNEKAN
V
E
SVF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
NGDENSAE
A
V
I
H
RA
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VEL
G
TA
T
GFDFE
L
IDQAGLGH
D
A
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
L
E
VD
QE
KA
Q
A
L
GVSL
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
ML
P
ED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QG
EA
APGT
S
S
G
D
A
MALMENLASK
L
-
-
P
A
G
IGYD
W
T
G
--
MS
YQ
ER
L
SGNQAPA
L
V
A
-
I
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLM
E
KE
----------
G
KGVV
EA
TLM
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
VS
A
T
LLAI
fig|585055.6.peg.3718
Escherichia coli 55989 (1-1005/1021)
M
L
----
AI
I
L
M
M
A
G
ALA
I
LQ
LPV
A
QYP
T
I
AP
P
A
V
S
V
S
A
N
YPGA
D
AQ
T
V
Q
D
T
VT
Q
VIE
QN
M
NG
I
D
N
LM
Y
MSS
T
S
DSA
G
SVT
ITL
T
F
Q
S
GT
D
PD
I
A
QV
QVQ
NK
LQ
L
A
TPL
LP
QEVQQQ
G
I
SVE-KSSSS
---
Y
L
MVA
G
FV
S
DNPDTTQD
DI
S
D
Y
V
ASN
V
KDT
LS
RLN
GVG
D
V
QLF
G
AQY-AM
RI
W
LD
A
DL
LN
KYK
L
TPVD
V
IN
QL
KVQ
N
DQIAA
GQLGG
T
P
ALPGQQLNAS
I
I
A
QTR
L
K
N
P
EEF
GK
V
T
L
RVNS
DG
SV
V
R
L
K
DVA
R
VE
L
G
G
E
NYNVI
A
RI
NGK
-
P
A
A
G
LG
I
K
L
AT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPF
FP
Q
G
M
K
VLYP
YDTT
PF
V
QL
SI
H
E
VVKT
L
F
EAI
M
LV
F
LV
M
YLFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
A
I
L
A
A
F
G
Y
S
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
D
KLP
P
KE
A
TE
K
SMS
QIQ
G
AL
VGIAMV
L
S
AVFIPM
A
F
FG
G
ST
G
A
IYR
Q
FSIT
IVS
AM
AL
SV
L
VAL
I
LTP
A
LCA
TL
L
KPTSAEHHENKGGFFGWF
N
TT
F
DHSVNH
----
Y
TNSVG
K
I
L
GSTGRY
L
L
I
Y
A
L
IVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VT
DYY
LKNEKAN
V
E
SVF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
NSDENSAE
A
V
I
H
RA
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VEL
G
TA
T
GFDFE
L
IDQAGLGH
D
A
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
L
E
VD
QE
KA
Q
A
L
GVSL
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
ML
P
ED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QG
EA
APGT
S
S
G
D
A
MALMENLASK
L
-
-
P
A
G
IGYD
W
T
G
--
MS
YQ
ER
L
SGNQAPA
L
V
A
-
I
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLM
E
KE
----------
G
KGVV
EA
TLM
A
VRM
R
L
H
PILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
VS
A
T
LLAI
fig|656414.3.peg.3746
Escherichia coli H736 (1-1018/1034)
M
ANFF
IRRP
IF
AWV
L
----
AI
I
L
M
M
A
G
ALA
I
LQ
LPV
A
QYP
T
I
AP
P
A
V
S
V
S
A
N
YPGA
D
AQ
T
V
Q
D
T
VT
Q
VIE
QN
M
NG
I
D
N
LM
Y
MSS
T
S
DSA
G
SVT
ITL
T
F
Q
S
GT
D
PD
I
A
QV
QVQ
NK
LQ
L
A
TPL
LP
QEVQQQ
G
I
SVE-KSSSS
---
Y
L
MVA
G
FV
S
DNPGTTQD
DI
S
D
Y
V
ASN
V
KDT
LS
RLN
GVG
D
V
QLF
G
AQY-AM
RI
W
LD
A
DL
LN
KYK
L
TPVD
V
IN
QL
KVQ
N
DQIAA
GQLGG
T
P
ALPGQQLNAS
I
I
A
QTR
F
K
N
P
EEF
GK
V
T
L
RVNS
DG
SV
V
R
L
K
DVA
R
VE
L
G
G
E
NYNVI
A
RI
NGK
-
P
A
A
G
LG
I
K
L
AT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPF
FP
Q
G
M
K
VLYP
YDTT
PF
V
QL
SI
H
E
VVKT
L
F
EAI
M
LV
F
LV
M
YLFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
A
I
L
A
A
F
G
Y
S
I
N
T
LTM
F
GM
V
LA
L
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
D
KLP
P
KE
A
TE
K
SMS
QIQ
G
AL
VGIAMV
L
S
AVFIPM
A
F
FG
G
ST
G
A
IYR
Q
FSIT
IVS
AM
AL
SV
L
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWF
N
TT
F
DHSVNH
----
Y
TNSVG
K
I
L
GSTGRY
L
L
I
Y
A
L
IVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VT
DYY
LKNEKAN
V
E
SVF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
NGDENSAE
A
V
I
H
RA
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VEL
G
TA
T
GFDFE
L
IDQAGLGH
D
A
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
L
E
VD
QE
KA
Q
A
L
GVSL
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
L
Y
VQ
ADAKF
R
ML
P
ED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QG
EA
APGT
S
S
G
D
A
MALMENLASK
L
-
-
P
A
G
IGYD
W
T
G
--
MS
YQ
ER
L
SGNQAPA
L
V
A
-
I
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLM
E
KE
----------
G
KGVV
EA
TLM
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
VS
A
T
LLAI
fig|749540.3.peg.3425
Escherichia coli MS 146-1 (1-1018/1034)
M
ANFF
IRRP
IF
AWV
L
----
AI
I
L
M
M
A
G
ALA
I
LQ
LPV
A
QYP
T
I
AP
P
A
V
S
V
S
A
N
YPGA
D
AQ
T
V
Q
D
T
VT
Q
VIE
QN
M
NG
I
D
N
LM
Y
MSS
T
S
DSA
G
SVT
ITL
T
F
Q
S
GT
D
PD
I
A
QV
QVQ
NK
LQ
L
A
TPL
LP
QEVQQQ
G
I
SVE-KSSSS
---
Y
L
MVA
G
FV
S
DNPGTTQD
DI
S
D
Y
V
ASN
V
KDT
LS
RLN
GVG
D
V
QLF
G
AQY-AM
RI
W
LD
A
DL
LN
KYK
L
TPVD
V
IN
QL
KVQ
N
DQIAA
GQLGG
T
P
ALPGQQLNAS
I
I
A
QTR
F
K
N
P
EEF
GK
V
T
L
RVNS
DG
SV
V
R
L
K
DVA
R
VE
L
G
G
E
NYNVI
A
RI
NGK
-
P
A
A
G
LG
I
K
L
AT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPF
FP
Q
G
M
K
VLYP
YDTT
PF
V
QL
SI
H
E
VVKT
L
F
EAI
M
LV
F
LV
M
YLFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
A
I
L
A
A
F
G
Y
S
I
N
T
LTM
F
GM
V
LA
L
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
D
KLP
P
KE
A
TE
K
SMS
QIQ
G
AL
VGIAMV
L
S
AVFIPM
A
F
FG
G
ST
G
A
IYR
Q
FSIT
IVS
AM
AL
SV
L
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWF
N
TT
F
DHSVNH
----
Y
TNSVG
K
I
L
GSTGRY
L
L
I
Y
A
L
IVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VT
DYY
LKNEKAN
V
E
SVF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
NGDENSAE
A
V
I
H
RA
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VEL
G
TA
T
GFDFE
L
IDQAGLGH
D
A
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
L
E
VD
QE
KA
Q
A
L
GVSL
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
L
Y
VQ
ADAKF
R
ML
P
ED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QG
EA
APGT
S
S
G
D
A
MALMENLASK
L
-
-
P
A
G
IGYD
W
T
G
--
MS
YQ
ER
L
SGNQAPA
L
V
A
-
I
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLM
E
KE
----------
G
KGVV
EA
TLM
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
VS
A
T
LLAI
fig|511693.5.peg.3285
Escherichia coli BL21 (1-1018/1034)
M
ANFF
IRRP
IF
AWV
L
----
AI
I
L
M
M
A
G
ALA
I
LQ
LPV
A
QYP
T
I
AP
P
A
V
S
V
S
A
N
YPGA
D
AQ
T
V
Q
D
T
VT
Q
VIE
QN
M
NG
I
D
N
LM
Y
MSS
T
S
DSA
G
SVT
ITL
T
F
Q
S
GT
D
PD
I
A
QV
QVQ
NK
LQ
L
A
TPL
LP
QEVQQQ
G
I
SVE-KSSSS
---
Y
L
MVA
G
FV
S
DNPDITQD
DI
S
D
Y
V
ASN
V
KDT
LS
RLN
GVG
D
V
QLF
G
AQY-AM
RI
W
LD
A
DL
LN
KYK
L
TPVD
V
IN
QL
KVQ
N
DQIAA
GQLGG
T
P
ALPGQQLNAS
I
I
A
QTR
L
K
N
P
EEF
GK
V
T
L
RVNS
DG
SV
V
R
L
K
DVA
R
VE
L
G
G
E
NYNVI
A
RI
NGK
-
P
A
A
G
LG
I
K
L
AT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPF
FP
Q
G
M
K
VLYP
YDTT
PF
V
QL
SI
H
E
VVKT
L
F
EAI
M
LV
F
LV
M
YLFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
A
I
L
A
A
F
G
Y
S
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
D
KLP
P
KE
A
TE
K
SMS
QIQ
G
AL
VGIAMV
L
S
AVFIPM
A
F
FG
G
ST
G
A
IYR
Q
FSIT
IVS
AM
AL
SV
L
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWF
N
TT
F
DHSVNH
----
Y
TNSVG
K
I
L
GSTGRY
L
L
I
Y
A
L
IVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VT
DYY
LKNEKAN
V
E
SVF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
NGDENSAE
A
V
I
H
RA
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VEL
G
TA
T
GFDFE
L
IDQAGLGH
D
A
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
L
E
VD
QE
KA
Q
A
L
GVSL
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
ML
P
ED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QG
EA
APGT
S
S
G
D
A
MALMENLASK
L
-
-
P
A
G
IGYD
W
T
G
--
MS
YQ
ER
L
SGNQAPA
L
V
A
-
I
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLM
E
KE
----------
G
KGVV
EA
TLM
A
VRM
H
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
VS
A
T
LLAI
fig|595496.3.peg.3248
Escherichia coli BW2952 (1-1005/1021)
M
L
----
AI
I
L
M
M
A
G
ALA
I
LQ
LPV
A
QYP
T
I
AP
P
A
V
S
V
S
A
N
YPGA
D
AQ
T
V
Q
D
T
VT
Q
VIE
QN
M
NG
I
D
N
LM
Y
MSS
T
S
DSA
G
SVT
ITL
T
F
Q
S
GT
D
PD
I
A
QV
QVQ
NK
LQ
L
A
TPL
LP
QEVQQQ
G
I
SVE-KSSSS
---
Y
L
MVA
G
FV
S
DNPGTTQD
DI
S
D
Y
V
ASN
V
KDT
LS
RLN
GVG
D
V
QLF
G
AQY-AM
RI
W
LD
A
DL
LN
KYK
L
TPVD
V
IN
QL
KVQ
N
DQIAA
GQLGG
T
P
ALPGQQLNAS
I
I
A
QTR
F
K
N
P
EEF
GK
V
T
L
RVNS
DG
SV
V
R
L
K
DVA
R
VE
L
G
G
E
NYNVI
A
RI
NGK
-
P
A
A
G
LG
I
K
L
AT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPF
FP
Q
G
M
K
VLYP
YDTT
PF
V
QL
SI
H
E
VVKT
L
F
EAI
M
LV
F
LV
M
YLFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
A
I
L
A
A
F
G
Y
S
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
D
KLP
P
KE
A
TE
K
SMS
QIQ
G
AL
VGIAMV
L
S
AVFIPM
A
F
FG
G
ST
G
A
IYR
Q
FSIT
IVS
AM
AL
SV
L
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWF
N
TT
F
DHSVNH
----
Y
TNSVG
K
I
L
GSTGRY
L
L
I
Y
A
L
IVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VT
DYY
LKNEKAN
V
E
SVF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
NGDENSAE
A
V
I
H
RA
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VEL
G
TA
T
GFDFE
L
IDQAGLGH
D
A
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
L
E
VD
QE
KA
Q
A
L
GVSL
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
L
Y
VQ
ADAKF
R
ML
P
ED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QG
EA
APGT
S
S
G
D
A
MALMENLASK
L
-
-
P
A
G
IGYD
W
T
G
--
MS
YQ
ER
L
SGNQAPA
L
V
A
-
I
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLM
E
KE
----------
G
KGVV
EA
TLM
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
VS
A
T
LLAI
fig|316385.7.peg.3468
Escherichia coli str. K-12 substr. DH10B (1-1005/1021)
M
L
----
AI
I
L
M
M
A
G
ALA
I
LQ
LPV
A
QYP
T
I
AP
P
A
V
S
V
S
A
N
YPGA
D
AQ
T
V
Q
D
T
VT
Q
VIE
QN
M
NG
I
D
N
LM
Y
MSS
T
S
DSA
G
SVT
ITL
T
F
Q
S
GT
D
PD
I
A
QV
QVQ
NK
LQ
L
A
TPL
LP
QEVQQQ
G
I
SVE-KSSSS
---
Y
L
MVA
G
FV
S
DNPGTTQD
DI
S
D
Y
V
ASN
V
KDT
LS
RLN
GVG
D
V
QLF
G
AQY-AM
RI
W
LD
A
DL
LN
KYK
L
TPVD
V
IN
QL
KVQ
N
DQIAA
GQLGG
T
P
ALPGQQLNAS
I
I
A
QTR
F
K
N
P
EEF
GK
V
T
L
RVNS
DG
SV
V
R
L
K
DVA
R
VE
L
G
G
E
NYNVI
A
RI
NGK
-
P
A
A
G
LG
I
K
L
AT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPF
FP
Q
G
M
K
VLYP
YDTT
PF
V
QL
SI
H
E
VVKT
L
F
EAI
M
LV
F
LV
M
YLFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
A
I
L
A
A
F
G
Y
S
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
D
KLP
P
KE
A
TE
K
SMS
QIQ
G
AL
VGIAMV
L
S
AVFIPM
A
F
FG
G
ST
G
A
IYR
Q
FSIT
IVS
AM
AL
SV
L
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWF
N
TT
F
DHSVNH
----
Y
TNSVG
K
I
L
GSTGRY
L
L
I
Y
A
L
IVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VT
DYY
LKNEKAN
V
E
SVF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
NGDENSAE
A
V
I
H
RA
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VEL
G
TA
T
GFDFE
L
IDQAGLGH
D
A
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
L
E
VD
QE
KA
Q
A
L
GVSL
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
L
Y
VQ
ADAKF
R
ML
P
ED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QG
EA
APGT
S
S
G
D
A
MALMENLASK
L
-
-
P
A
G
IGYD
W
T
G
--
MS
YQ
ER
L
SGNQAPA
L
V
A
-
I
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLM
E
KE
----------
G
KGVV
EA
TLM
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
VS
A
T
LLAI
fig|585397.7.peg.3929
Escherichia coli ED1a (1-1018/1034)
M
ANFF
IRRP
IF
AWV
L
----
AI
I
L
M
M
A
G
ALA
I
LQ
LPV
A
QYP
T
I
AP
P
A
V
S
V
S
A
N
YPGA
D
AQ
T
V
Q
D
T
VT
Q
VIE
QN
M
NG
I
D
N
LM
Y
MSS
T
S
DSA
G
SVT
ITL
T
F
Q
S
GT
D
PD
I
A
QV
QVQ
NK
LQ
L
A
TPL
LP
QEVQQQ
G
I
SVE-KSSSS
---
Y
L
MVA
G
FV
S
DNPGTTQD
DI
S
D
Y
V
ASN
V
KDT
LS
RLN
GVG
D
V
QLF
G
AQY-AM
RI
W
LD
A
DL
LN
KYK
L
TPVD
V
IN
QL
KVQ
N
DQIAA
GQLGG
T
P
ALPGQQLNAS
I
I
A
QTR
L
K
N
P
EEF
GK
V
T
L
RVNS
DG
SV
V
R
L
K
DVA
R
VE
L
G
G
E
NYNVI
A
RI
NGK
-
P
A
A
G
LG
I
K
L
AT
GAN
ALD
T
AKA
I
KAK
P
AE
L
QPF
FP
Q
G
M
K
VLYP
YDTT
PF
V
QL
SI
Q
E
VVKT
L
F
EAI
M
LV
F
LV
M
YLFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
A
I
L
A
A
F
G
Y
S
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
D
KLP
P
RE
A
TE
K
SMS
QIQ
G
AL
VGIAMV
L
S
AVFIPM
A
F
FG
G
ST
G
A
IYR
Q
FSIT
IVS
AM
AL
SV
L
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWF
N
TT
F
DHSVNH
----
Y
TNSVG
K
I
L
GSTGRY
L
L
I
Y
A
L
IVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VT
DYY
LKNEKAN
V
E
SVF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
SGDENSAE
A
V
I
H
RA
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VEL
G
TA
T
GFDFE
L
IDQAGLGH
D
A
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
L
E
VD
QE
KA
Q
A
L
GVSL
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
ML
P
ED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QG
EA
APGT
S
S
G
D
A
MALMENLASK
L
-
-
P
A
G
IGYD
W
T
G
--
MS
YQ
ER
L
SGNQAPA
L
V
A
-
I
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLM
E
KE
----------
G
KGVV
EA
TLM
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
VS
A
T
LLAI
fig|585397.9.peg.3926
Escherichia coli ED1a (1-1018/1034)
M
ANFF
IRRP
IF
AWV
L
----
AI
I
L
M
M
A
G
ALA
I
LQ
LPV
A
QYP
T
I
AP
P
A
V
S
V
S
A
N
YPGA
D
AQ
T
V
Q
D
T
VT
Q
VIE
QN
M
NG
I
D
N
LM
Y
MSS
T
S
DSA
G
SVT
ITL
T
F
Q
S
GT
D
PD
I
A
QV
QVQ
NK
LQ
L
A
TPL
LP
QEVQQQ
G
I
SVE-KSSSS
---
Y
L
MVA
G
FV
S
DNPGTTQD
DI
S
D
Y
V
ASN
V
KDT
LS
RLN
GVG
D
V
QLF
G
AQY-AM
RI
W
LD
A
DL
LN
KYK
L
TPVD
V
IN
QL
KVQ
N
DQIAA
GQLGG
T
P
ALPGQQLNAS
I
I
A
QTR
L
K
N
P
EEF
GK
V
T
L
RVNS
DG
SV
V
R
L
K
DVA
R
VE
L
G
G
E
NYNVI
A
RI
NGK
-
P
A
A
G
LG
I
K
L
AT
GAN
ALD
T
AKA
I
KAK
P
AE
L
QPF
FP
Q
G
M
K
VLYP
YDTT
PF
V
QL
SI
Q
E
VVKT
L
F
EAI
M
LV
F
LV
M
YLFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
A
I
L
A
A
F
G
Y
S
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
D
KLP
P
RE
A
TE
K
SMS
QIQ
G
AL
VGIAMV
L
S
AVFIPM
A
F
FG
G
ST
G
A
IYR
Q
FSIT
IVS
AM
AL
SV
L
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWF
N
TT
F
DHSVNH
----
Y
TNSVG
K
I
L
GSTGRY
L
L
I
Y
A
L
IVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VT
DYY
LKNEKAN
V
E
SVF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
SGDENSAE
A
V
I
H
RA
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VEL
G
TA
T
GFDFE
L
IDQAGLGH
D
A
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
L
E
VD
QE
KA
Q
A
L
GVSL
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
ML
P
ED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QG
EA
APGT
S
S
G
D
A
MALMENLASK
L
-
-
P
A
G
IGYD
W
T
G
--
MS
YQ
ER
L
SGNQAPA
L
V
A
-
I
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLM
E
KE
----------
G
KGVV
EA
TLM
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
VS
A
T
LLAI
fig|481805.6.peg.468
Escherichia coli ATCC 8739 (1-1005/1021)
M
L
----
AI
I
L
M
M
A
G
ALA
I
LQ
LPV
A
QYP
T
I
AP
P
A
V
S
V
S
A
N
YPGA
D
AQ
T
V
Q
D
T
VT
Q
VIE
QN
M
NG
I
D
N
LM
Y
MSS
T
S
DSA
G
SVT
ITL
T
F
Q
S
GT
D
PD
I
A
QV
QVQ
NK
LQ
L
A
TPL
LP
QEVQQQ
G
I
SVE-KSSSS
---
Y
L
MVA
G
FV
S
DNPDTTQD
DI
S
D
Y
V
ASN
V
KDT
LS
RLN
GVG
D
V
QLF
G
AQY-AM
RI
W
LD
A
DL
LN
KYK
L
TPVD
V
IN
QL
KVQ
N
DQIAA
GQLGG
T
P
ALPGQQLNAS
I
I
A
QTR
L
K
N
P
EEF
GK
V
T
L
RVNS
DG
SV
V
R
L
K
DVA
R
VE
L
G
G
E
NYNVI
A
RI
NGK
-
P
A
A
G
LG
I
K
L
AT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPF
FP
Q
G
M
K
VLYP
YDTT
PF
V
QL
SI
H
E
VVKT
L
F
EAI
M
LV
F
LV
M
YLFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
A
I
L
A
A
F
G
Y
S
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVE
K
VE
R
V
M
M
E
----------
D
KLP
P
KE
A
TE
K
SMS
QIQ
G
AL
VGIAMV
L
S
AVFIPM
A
F
FG
G
ST
G
A
IYR
Q
FSIT
IVS
AM
AL
SV
L
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWF
N
TT
F
DHSVNH
----
Y
TNSVG
K
I
L
GSTGRY
L
L
I
Y
A
L
IVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VT
DYY
LKNEKAN
V
E
SVF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
NGDENSAE
A
V
I
H
RA
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VEL
G
TA
T
GFDFE
L
IDQAGLGH
D
A
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
L
E
VD
QE
KA
Q
A
L
GVSL
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
ML
P
ED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QG
EA
APGT
S
S
G
D
A
MALMENLASK
L
-
-
P
A
G
IGYD
W
T
G
--
MS
YQ
ER
L
SGNQAPA
L
V
A
-
I
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLM
E
KE
----------
G
KGVV
EA
TLM
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
VS
A
T
LLAI
fig|413997.3.peg.3273
Escherichia coli B str. REL606 (1-1005/1021)
M
L
----
AI
I
L
M
M
A
G
ALA
I
LQ
LPV
A
QYP
T
I
AP
P
A
V
S
V
S
A
N
YPGA
D
AQ
T
V
Q
D
T
VT
Q
VIE
QN
M
NG
I
D
N
LM
Y
MSS
T
S
DSA
G
SVT
ITL
T
F
Q
S
GT
D
PD
I
A
QV
QVQ
NK
LQ
L
A
TPL
LP
QEVQQQ
G
I
SVE-KSSSS
---
Y
L
MVA
G
FV
S
DNPDITQD
DI
S
D
Y
V
ASN
V
KDT
LS
RLN
GVG
D
V
QLF
G
AQY-AM
RI
W
LD
A
DL
LN
KYK
L
TPVD
V
IN
QL
KVQ
N
DQIAA
GQLGG
T
P
ALPGQQLNAS
I
I
A
QTR
L
K
N
P
EEF
GK
V
T
L
RVNS
DG
SV
V
R
L
K
DVA
R
VE
L
G
G
E
NYNVI
A
RI
NGK
-
P
A
A
G
LG
I
K
L
AT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPF
FP
Q
G
M
K
VLYP
YDTT
PF
V
QL
SI
H
E
VVKT
L
F
EAI
M
LV
F
LV
M
YLFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
A
I
L
A
A
F
G
Y
S
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
D
KLP
P
KE
A
TE
K
SMS
QIQ
G
AL
VGIAMV
L
S
AVFIPM
A
F
FG
G
ST
G
A
IYR
Q
FSIT
IVS
AM
AL
SV
L
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWF
N
TT
F
DHSVNH
----
Y
TNSVG
K
I
L
GSTGRY
L
L
I
Y
A
L
IVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VT
DYY
LKNEKAN
V
E
SVF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
NGDENSAE
A
V
I
H
RA
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VEL
G
TA
T
GFDFE
L
IDQAGLGH
D
A
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
L
E
VD
QE
KA
Q
A
L
GVSL
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
ML
P
ED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QG
EA
APGT
S
S
G
D
A
MALMENLASK
L
-
-
P
A
G
IGYD
W
T
G
--
MS
YQ
ER
L
SGNQAPA
L
V
A
-
I
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLM
E
KE
----------
G
KGVV
EA
TLM
A
VRM
H
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
VS
A
T
LLAI
fig|469008.4.peg.492
Escherichia coli BL21(DE3) (1-1005/1021)
M
L
----
AI
I
L
M
M
A
G
ALA
I
LQ
LPV
A
QYP
T
I
AP
P
A
V
S
V
S
A
N
YPGA
D
AQ
T
V
Q
D
T
VT
Q
VIE
QN
M
NG
I
D
N
LM
Y
MSS
T
S
DSA
G
SVT
ITL
T
F
Q
S
GT
D
PD
I
A
QV
QVQ
NK
LQ
L
A
TPL
LP
QEVQQQ
G
I
SVE-KSSSS
---
Y
L
MVA
G
FV
S
DNPDITQD
DI
S
D
Y
V
ASN
V
KDT
LS
RLN
GVG
D
V
QLF
G
AQY-AM
RI
W
LD
A
DL
LN
KYK
L
TPVD
V
IN
QL
KVQ
N
DQIAA
GQLGG
T
P
ALPGQQLNAS
I
I
A
QTR
L
K
N
P
EEF
GK
V
T
L
RVNS
DG
SV
V
R
L
K
DVA
R
VE
L
G
G
E
NYNVI
A
RI
NGK
-
P
A
A
G
LG
I
K
L
AT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPF
FP
Q
G
M
K
VLYP
YDTT
PF
V
QL
SI
H
E
VVKT
L
F
EAI
M
LV
F
LV
M
YLFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
A
I
L
A
A
F
G
Y
S
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
D
KLP
P
KE
A
TE
K
SMS
QIQ
G
AL
VGIAMV
L
S
AVFIPM
A
F
FG
G
ST
G
A
IYR
Q
FSIT
IVS
AM
AL
SV
L
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWF
N
TT
F
DHSVNH
----
Y
TNSVG
K
I
L
GSTGRY
L
L
I
Y
A
L
IVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VT
DYY
LKNEKAN
V
E
SVF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
NGDENSAE
A
V
I
H
RA
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VEL
G
TA
T
GFDFE
L
IDQAGLGH
D
A
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
L
E
VD
QE
KA
Q
A
L
GVSL
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
ML
P
ED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QG
EA
APGT
S
S
G
D
A
MALMENLASK
L
-
-
P
A
G
IGYD
W
T
G
--
MS
YQ
ER
L
SGNQAPA
L
V
A
-
I
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLM
E
KE
----------
G
KGVV
EA
TLM
A
VRM
H
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
VS
A
T
LLAI
fig|749546.3.peg.1815
Escherichia coli MS 185-1 (1-1018/1034)
M
ANFF
IRRP
IF
AWV
L
----
AI
I
L
M
M
A
G
ALA
I
LQ
LPV
A
QYP
T
I
AP
P
A
V
S
V
S
A
N
YPGA
D
AQ
T
V
Q
D
T
VT
Q
VIE
QN
M
NG
I
D
N
LM
Y
MSS
T
S
DSA
G
SVT
ITL
T
F
Q
S
GT
D
PD
I
A
QV
QVQ
NK
LQ
L
A
TPL
LP
QEVQQQ
G
I
SVE-KSSSS
---
Y
L
MVA
G
FV
S
DNPGTTQD
DI
S
D
Y
V
ASN
V
KDT
LS
RLN
GVG
D
V
QLF
G
AQY-AM
RI
W
LD
A
DL
LN
KYK
L
TPVD
V
IN
QL
KVQ
N
DQIAA
GQLGG
T
P
ALPGQQLNAS
I
I
A
QTR
L
K
N
P
EEF
GK
V
T
L
RVNS
DG
SV
V
R
L
K
Y
VA
R
VE
L
G
G
E
NYNVI
A
RI
NGK
-
P
A
A
G
LG
I
K
L
AT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPF
FP
Q
G
M
K
VLYP
YDTT
PF
V
QL
SI
Q
E
VVKT
L
F
EAI
M
LV
F
LV
M
YLFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
A
I
L
A
A
F
G
Y
S
I
N
T
LTM
F
GM
V
LA
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
D
KLP
P
RE
A
TE
K
SMS
QIQ
G
AL
VGIAMV
L
S
AVFIPM
A
F
FG
G
ST
G
A
IYR
Q
FSIT
IVS
AM
AL
SV
L
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWF
N
TT
F
DHSVNH
----
Y
TNSVG
K
I
L
GSTGRY
L
L
I
Y
A
L
IVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VT
DYY
LKNEKAN
V
E
SVF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
SGDENSAE
A
V
I
H
RA
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VEL
G
TA
T
GFDFE
L
IDQAGLGH
D
A
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
L
E
VD
QE
KA
Q
A
L
GVSL
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
ML
P
ED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QG
EA
APGT
S
S
G
D
A
MALMENLASK
L
-
-
P
A
G
IGYD
W
T
G
--
MS
YQ
ER
L
SGNQAPA
L
V
A
-
I
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLM
E
KE
----------
G
KGVV
EA
TLM
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
VS
A
T
LLAI
Consen1
Primary consensus
MiewiIrRpva
L
----
ai
l
l
G
i
lPV
qyP
l
p
v
v
a
YPGa
aq
v
n
VT
vie
m
l
glm
mss
S
G
itl
Fe
gt
pd
A
qVq
lq
a
LP
gv
---
i
a
s
di
d
v
v
ls
gVg
v
G
ri
ldp
ln
l
V
ai
N
gqlgg
p
i
a
lqt
eef
i
l
dG
v
L
DVA
Ve
G
E
a
Ngk
-
a
g
v
l
GaN
t
v
L
L
fP
gvk
ydtt
i
si
d
L
eai
lV
lv
yLFL
n
ratlip
iavPv
l
gtF
vl
a
g
s
N
ltm
gm
lA
G
lVDdAIVvvEN
r
i
E
----------
d
p
a
k
qiq
al
l
avfiPm
f
g
G
iyr
fsiT
am
sv
val
ltP
lca
l
n
f
----
Y
kvL
l
vy
l
l
p
FlP
d
G
q
p
g
t
q
dyy
v
svf
G
n
---
i
LKp
e
-
R
aiI
ra
v
p
-
i
g
s
l
d
l
ql
a
P
l
v
n
le
vnvd
kA
a
Gvsl
Di
l
tA
G
v
k
v
vq
r
p
l
v
n
g
pls
a
gs
l
n
p
I
ea
s
g
a
l
-
p
g
w
g
--
yq
l
L
a
-
s
v
vfl
L
lyes
p
vml
vP
g
vG
lla
g
ndV
G
l
iGl
aknailiv
fa
q
----------
g
eA
a
R
RPilMT
la
i
G
LPl
s
GaGsg
vg
gvmGGm
a
lLaif
P
y
LvWLHRHRVRK
Consen2
Secondary consensus
anff
m
sif
vlmgm
y
t
al
v
i
i
t
q
pd
plt
f
nak
vrg
vyv
tl
ly
l
in
v
pi
gvg
l
g
d
q
s
q
ik
d
a
i
qv
ina
ia
ql
ssi
--
-
v
mk
d
y
i
n
i
q
s
k
g
v
v
i
r
k
v
i
l
s
e
sers
v
av
mef
v
i
a
h
psaiva
vsl
l
i
ia
im
f
d
msl
a
i
a
mi
k
wqhqhpdatl
r
v
d
evg
ti
i
lsl
t
d
lfg
laf
si
aa
ls
vi
mmg
i
e
l
s
ia
s
p
g
f
n
s
l
s
s
k
k
--
i
rlt
a
ettv
d
qw
kv
el
l
a
r
v
v
e
m
ei
l
v
a
qd
in
s
r
v
i
y
i
l
t
l
k
tfa
ap
i
d
s
v
m
s
v
v
lk
d
f
ast
fe
e
vp
y
afrr
a
i
s
l
a
i
iwl
n
ls
i
a
kefgv
m
yl
pslnnpqtfse
d
g
ka
av
l
g
v
ae
a
pm
l
s
ly
f
m
Consensus 1
(when a gap)
Conservative difference
Consensus 2
(when a gap)
Nonconservative diff.
Other character