fig|199310.1.peg.544
Escherichia coli CFT073 (39-631/631)
MRSFSQLW
P
T
LK
RL
LAYGSP
W
--------
-
R
KPL
G
I
A
V
LMM
WV
A
AAA-
--
E
V
SG
P
LLISYFI
D
N
MVAKNN
L
PLK
V
V
A
G
LA
AA
Y
VGL
QL
FAAG
L
----
---
-
--H
Y
AQ
S
L
L
FNR
A
AVG
VV
QQ
LR
T
D
VMDAAL
RQP
L
S
E
FD
T
Q
P
V
G
Q
V
ISR
V
TND
T
E
VIRDLYV
T
VV
A-------
TV
L
R
SA
ALV
G
A
---
M
L
V
A
MF
SL
D
W
RM
---
A
L
V
A
I
M
I
F
PVV
LV
VMVIYQ
R
YSTP
IV
R
RVR
A
YLA
D
I
ND
----
G
FNE
I
IN
G
MSV
I
QQ
F
R
-----------
QQA
R
FGERMGEASRSHYMAR
MQ
TL
R
L
D
G
F
LL
R
P
L
L
S
L
FS
SL
I
L
CG
LL
M
L
F
G
F
S
---
A
S
G
TIE
V
G
V
L
Y
A
F
I
SYLG
R
L
NE
PL
IE
LT
TQ
-------
Q
A
ML
Q
Q
AV
V
A
GERV
F
E
L
M
DG
P
R
QQ
-----
Y
GNDD
R
PLQ
S
GT
-
-
I
E
VD
NV
S
F
A
Y
-
RD
D
N
LV
LKNINL
S
V
P
S
R
NF
VALVG
H
TGSGKSTLASL
L
M
G
YY
P
L
T
EGEIR
L
DG
R
PL
SS
L
S
H
S
A
LR
QG
VAMV
Q
Q
D
P
V
VL
ADT
FLA
N
VT
LG
-
-RDI
SEER
VW
Q
A
LE
T
V
QLA
E
L
A
RS
M
SD
G
I
Y
T
P
LGE
Q
G
N
N
LS
V
GQKQ
LL
A
L
AR
V
L
V
ETPQ
ILILDEAT
AS
ID
SG
TE
Q
AIQHAL
AAVR
E
H
T
T
L
V
VIAHRLSTI
V
DAD
T
I
L
VL
HR
G
Q
A
VE
Q
GTH
QQ
LL
AAQ
G
R
Y
W
QMYQ
L
Q
LA
GEELAASVR
E
EESLSA
fig|216592.1.peg.4766
Escherichia coli 042 (39-631/631)
MRSFSQLW
P
T
LK
RL
LAYGSP
W
--------
-
R
KPL
G
I
A
V
LMM
WV
A
AAA-
--
E
V
SG
P
LLISYFI
D
N
MVAKNN
L
PLK
V
V
A
G
LA
AA
Y
VGL
QL
FAAG
L
----
---
-
--H
Y
AQ
S
L
L
FNR
A
AVG
VV
QQ
LR
T
D
VMDAAL
RQP
L
S
E
FD
T
Q
P
V
G
Q
V
ISR
V
TND
T
E
VIRDLYV
T
VV
A-------
TV
L
R
SA
ALV
G
A
---
M
L
V
A
MF
SL
D
W
RM
---
A
L
V
A
I
M
I
F
PVV
LV
VMVIYQ
R
YSTP
IV
R
RVR
A
YLA
D
I
ND
----
G
FNE
I
IN
G
MSV
I
QQ
F
R
-----------
QQA
R
FGERMGEASRSHYMAR
MQ
TL
R
L
D
G
F
LL
R
P
L
L
S
L
FS
SL
I
L
CG
LL
I
L
F
G
F
S
---
A
S
G
TIE
V
G
V
L
Y
A
F
I
SYLG
R
L
NE
PL
IE
LT
TQ
-------
Q
A
ML
Q
Q
AV
V
A
GERV
F
E
L
M
DG
P
R
QQ
-----
Y
GNDD
R
PLQ
S
GT
-
-
I
E
VD
NV
S
F
A
Y
-
RD
D
N
LV
LKNINL
S
V
P
S
R
NF
VALVG
H
TGSGKSTLASL
L
M
G
YY
P
L
T
EGEIR
L
DG
R
PL
SS
L
S
H
S
A
LR
QG
VAMV
Q
Q
D
P
V
VL
ADT
FLA
N
VT
LG
-
-RDI
SEER
VW
Q
A
LE
T
V
QLA
E
L
A
RS
M
SD
G
I
Y
T
P
LGE
Q
G
N
N
LS
V
GQKQ
LL
A
L
AR
V
L
V
ETPQ
ILILDEAT
AS
ID
SG
TE
Q
AIQHAL
AAVR
E
H
T
T
L
V
VIAHRLSTI
V
DAD
T
I
L
VL
HR
G
Q
A
VE
Q
GTH
QQ
LL
AAQ
G
R
Y
W
QMYQ
L
Q
LA
GEELAASVR
E
EESLSA
fig|216593.1.peg.3151
Escherichia coli E2348/69 (39-631/631)
MRSFSQLW
P
T
LK
RL
LAYGSP
W
--------
-
R
KPL
G
I
A
V
LMM
WV
A
AAA-
--
E
V
SG
P
LLISYFI
D
N
MVAKNN
L
PLK
V
V
A
G
LA
AA
Y
VGL
QL
FAAG
L
----
---
-
--H
Y
AQ
S
L
L
FNR
A
AVG
VV
QQ
LR
T
D
VMDAAL
RQP
L
S
E
FD
T
Q
P
V
G
Q
V
ISR
V
TND
T
E
VIRDLYV
T
VV
A-------
TV
L
R
SA
ALV
G
A
---
M
L
V
A
MF
SL
D
W
RM
---
A
L
V
A
I
M
I
F
PVV
LV
VMVIYQ
R
YSTP
IV
R
RVR
A
YLA
D
I
ND
----
G
FNE
I
IN
G
MSV
I
QQ
F
R
-----------
QQA
R
FGERMGEASRSHYMAR
MQ
TL
R
L
D
G
F
LL
R
P
L
L
S
L
FS
SL
I
L
CG
LL
M
L
F
G
F
S
---
A
S
G
TIE
V
G
V
L
Y
A
F
I
SYLG
R
L
NE
PL
IE
LT
TQ
-------
Q
A
ML
Q
Q
AV
V
A
GERV
F
E
L
M
DG
P
R
QQ
-----
Y
GNDD
R
PLQ
S
GT
-
-
I
D
VD
NV
S
F
A
Y
-
RD
D
N
LV
LKNINL
S
V
P
S
R
NF
VALVG
H
TGSGKSTLASL
L
M
G
YY
P
L
T
EGEIR
L
DG
R
PL
ST
L
S
H
S
A
LR
QG
V
T
MV
Q
Q
D
P
V
VL
ADT
FLA
N
VT
LG
-
-RDI
SEER
VW
Q
A
LE
T
V
QLA
E
L
A
RS
M
SD
G
I
Y
T
P
LGE
Q
G
N
N
LS
V
GQKQ
LL
A
L
AR
V
L
V
ETPQ
ILILDEAT
AS
ID
SG
TE
Q
AIQHAL
AAVR
E
H
T
T
L
V
VIAHRLSTI
V
DAD
T
I
L
VL
HR
G
Q
A
VE
Q
GTH
QQ
LL
AAQ
G
R
Y
W
QMYQ
L
Q
LA
GEELAASVR
E
EESLSA
fig|405955.9.peg.370
Escherichia coli APEC O1 (39-631/631)
MRSFSQLW
P
T
LK
RL
LAYGSP
W
--------
-
R
KPL
G
I
A
V
LMM
WV
A
AAA-
--
E
V
SG
P
LLISYFI
D
N
MVAKNN
L
PLK
V
G
A
G
LA
AA
Y
VGL
QL
FAAG
L
----
---
-
--H
Y
AQ
S
L
L
FNR
A
AVG
VV
QQ
LR
T
D
VMDAAL
RQP
L
S
E
FD
T
Q
P
V
G
Q
V
ISR
V
TND
T
E
VIRDLYV
T
VV
A-------
TV
L
R
SA
ALV
G
A
---
M
L
V
A
MF
SL
D
W
RM
---
A
L
V
A
I
M
I
F
PVV
LV
VMVIYQ
R
YSTP
IV
R
RVR
A
YLA
D
I
ND
----
G
FNE
I
IN
G
MSV
I
QQ
F
R
-----------
QQA
R
FGERMGEASRSHYMAR
MQ
TL
R
L
D
G
F
LL
R
P
L
L
S
L
FS
SL
I
L
CG
LL
M
L
F
G
F
S
---
A
S
G
TIE
V
G
V
L
Y
A
F
I
SYLG
R
L
NE
PL
IE
LT
TQ
-------
Q
A
ML
Q
Q
AV
V
A
GERV
F
E
L
M
DG
P
R
QQ
-----
Y
GNDD
R
PLQ
S
GT
-
-
I
D
VD
NV
S
F
A
Y
-
RD
D
N
LV
LKNINL
S
V
P
S
R
NF
VALVG
H
TGSGKSTLASL
L
M
G
YY
P
L
T
EGEIR
L
DG
R
PL
ST
L
S
H
S
A
LR
QG
VAMV
Q
Q
D
P
V
VL
ADT
FLA
N
VT
LG
-
-RDI
SEER
VW
Q
A
LE
I
V
QLA
E
L
A
RS
M
SD
G
I
Y
T
P
LGE
Q
G
N
N
LS
V
GQKQ
LL
A
L
AR
V
L
V
ETPQ
ILILDEAT
AS
ID
SG
TE
Q
AIQHAL
AAVR
E
H
T
T
L
V
VIAHRLSTI
V
DAD
T
I
L
VL
HR
G
Q
A
VE
Q
GTH
QQ
LL
AAQ
G
R
Y
W
QMYQ
L
Q
LA
GEELAASVR
E
EESLSA
fig|1040638.4.peg.5142
Escherichia coli O104:H4 str. LB226692
MRSFSQLW
P
T
LK
RL
LAYGSP
W
--------
-
R
KPL
G
I
A
V
LMM
WV
A
AAA-
--
E
V
SG
P
LLISYFI
D
N
MVAKNN
L
PLK
M
V
A
G
LA
AA
Y
VGL
QL
FAAG
L
----
---
-
--H
Y
AQ
S
L
L
FNR
A
AVG
VV
QQ
LR
T
D
VMDAAL
RQP
L
S
E
FD
T
Q
P
V
G
Q
V
ISR
V
TND
T
E
VIRDLYV
T
VV
A-------
TV
L
R
SA
ALV
G
A
---
M
L
V
A
MF
SL
D
W
RM
---
A
L
V
A
I
M
I
F
PVV
LV
VMVIYQ
R
YSTP
IV
R
RVR
A
YLA
D
I
ND
----
G
FNE
I
IN
G
MSV
I
QQ
F
R
-----------
QQA
R
FGERMGEASRSHYMAR
MQ
TL
R
L
D
G
F
LL
R
P
L
L
S
L
FS
SL
I
L
CG
LL
M
L
F
G
F
S
---
A
S
G
TIE
V
G
V
L
Y
A
F
I
SYLG
R
L
NE
PL
IE
LT
TQ
-------
Q
A
ML
Q
Q
AV
V
A
GERV
F
E
L
M
DG
P
R
QQ
-----
Y
GNDD
R
PLQ
S
GT
-
-
I
E
VD
NV
S
F
A
Y
-
RD
D
N
LV
LKNINL
S
V
P
S
R
NF
VALVG
H
TGSGKSTLASL
L
M
G
YY
P
L
T
EGEIR
L
DG
R
PL
SS
L
S
H
S
A
LR
QG
VAMV
Q
Q
D
P
V
VL
ADT
FLA
N
VT
LG
-
-RDI
SEER
VW
Q
A
LE
T
V
QLA
E
L
A
RS
M
SD
G
I
Y
T
P
LGE
Q
G
N
N
LS
V
GQKQ
LL
A
L
AR
V
L
V
ETPQ
ILILDEAT
AS
ID
SG
TE
Q
AIQHAL
AAVR
E
H
T
T
L
V
VIAHRLSTI
V
DAD
T
I
L
VL
HR
G
Q
A
VE
Q
GTH
QQ
LL
AAQ
G
R
Y
W
QMYQ
L
Q
LA
GEELAASVR
E
EESLSA
fig|6666666.5357.peg.1401
Escherichia coli TY-2482
MRSFSQLW
P
T
LK
RL
LAYGSP
W
--------
-
R
KPL
G
I
A
V
LMM
WV
A
AAA-
--
E
V
SG
P
LLISYFI
D
N
MVAKNN
L
PLK
M
V
A
G
LA
AA
Y
VGL
QL
FAAG
L
----
---
-
--H
Y
AQ
S
L
L
FNR
A
AVG
VV
QQ
LR
T
D
VMDAAL
RQP
L
S
E
FD
T
Q
P
V
G
Q
V
ISR
V
TND
T
E
VIRDLYV
T
VV
A-------
TV
L
R
SA
ALV
G
A
---
M
L
V
A
MF
SL
D
W
RM
---
A
L
V
A
I
M
I
F
PVV
LV
VMVIYQ
R
YSTP
IV
R
RVR
A
YLA
D
I
ND
----
G
FNE
I
IN
G
MSV
I
QQ
F
R
-----------
QQA
R
FGERMGEASRSHYMAR
MQ
TL
R
L
D
G
F
LL
R
P
L
L
S
L
FS
SL
I
L
CG
LL
M
L
F
G
F
S
---
A
S
G
TIE
V
G
V
L
Y
A
F
I
SYLG
R
L
NE
PL
IE
LT
TQ
-------
Q
A
ML
Q
Q
AV
V
A
GERV
F
E
L
M
DG
P
R
QQ
-----
Y
GNDD
R
PLQ
S
GT
-
-
I
E
VD
NV
S
F
A
Y
-
RD
D
N
LV
LKNINL
S
V
P
S
R
NF
VALVG
H
TGSGKSTLASL
L
M
G
YY
P
L
T
EGEIR
L
DG
R
PL
SS
L
S
H
S
A
LR
QG
VAMV
Q
Q
D
P
V
VL
ADT
FLA
N
VT
LG
-
-RDI
SEER
VW
Q
A
LE
T
V
QLA
E
L
A
RS
M
SD
G
I
Y
T
P
LGE
Q
G
N
N
LS
V
GQKQ
LL
A
L
AR
V
L
V
ETPQ
ILILDEAT
AS
ID
SG
TE
Q
AIQHAL
AAVR
E
H
T
T
L
V
VIAHRLSTI
V
DAD
T
I
L
VL
HR
G
Q
A
VE
Q
GTH
QQ
LL
AAQ
G
R
Y
W
QMYQ
L
Q
LA
GEELAASVR
E
EESLSA
fig|358709.5.peg.2105
Escherichia coli 101-1
MRSFSQLW
P
T
LK
RL
LAYGSP
W
--------
-
R
KPL
G
I
A
V
LMM
WV
A
AAA-
--
E
V
SG
P
LLISYFI
D
N
MVAKNN
L
PLK
M
V
A
G
LA
AA
Y
VGL
QL
FAAG
L
----
---
-
--H
Y
AQ
S
L
L
FNR
A
AVG
VV
QQ
LR
T
D
VMDAAL
RQP
L
S
E
FD
T
Q
P
V
G
Q
V
ISR
V
TND
T
E
VIRDLYV
T
VV
A-------
TV
L
R
SA
ALV
G
A
---
M
L
V
A
MF
SL
D
W
RM
---
A
L
V
A
I
M
I
F
PVV
LV
VMVIYQ
R
YSTP
IV
R
RVR
A
YLA
D
I
ND
----
G
FNE
I
IN
G
MSV
I
QQ
F
R
-----------
QQA
R
FGERMGEASRSHYMAR
MQ
TL
R
L
D
G
F
LL
R
P
L
L
S
L
FS
SL
I
L
CG
LL
M
L
F
G
F
S
---
A
S
G
TIE
V
G
V
L
Y
A
F
I
SYLG
R
L
NE
PL
IE
LT
TQ
-------
Q
A
ML
Q
Q
AV
V
A
GERV
F
E
L
M
DG
P
R
QQ
-----
Y
GNDD
R
PLQ
S
GT
-
-
I
E
VD
NV
S
F
A
Y
-
RD
D
N
LV
LKNINL
S
V
P
S
R
NF
VALVG
H
TGSGKSTLASL
L
M
G
YY
P
L
T
EGEIR
L
DG
R
PL
SS
L
S
H
S
A
LR
QG
VAMV
Q
Q
D
P
V
VL
ADT
FLA
N
VT
LG
-
-RDI
SEER
VW
Q
A
LE
T
V
QLA
E
L
A
RS
M
SD
G
I
Y
T
P
LGE
Q
G
N
N
LS
V
GQKQ
LL
A
L
AR
V
L
V
ETPQ
ILILDEAT
AS
ID
SG
TE
Q
AIQHAL
AAVR
E
H
T
T
L
V
VIAHRLSTI
V
DAD
T
I
L
VL
HR
G
Q
A
VE
Q
GTH
QQ
LL
AAQ
G
R
Y
W
QMYQ
L
Q
LA
GEELAASVR
E
EESLSA
fig|585055.6.peg.471
Escherichia coli 55989
MRSFSQLW
P
T
LK
RL
LAYGSP
W
--------
-
R
KPL
G
I
A
V
LMM
WV
A
AAA-
--
E
V
SG
P
LLISYFI
D
N
MVAKNN
L
PLK
M
V
A
G
LA
AA
Y
VGL
QL
FAAG
L
----
---
-
--H
Y
AQ
S
L
L
FNR
A
AVG
VV
QQ
LR
T
D
VMDAAL
RQP
L
S
E
FD
T
Q
P
V
G
Q
V
ISR
V
TND
T
E
VIRDLYV
T
VV
A-------
TV
L
R
SA
ALV
G
A
---
M
L
V
A
MF
SL
D
W
RM
---
A
L
V
A
I
M
I
F
PVV
LV
VMVIYQ
R
YSTP
IV
R
RVR
A
YLA
D
I
ND
----
G
FNE
I
IN
G
MSV
I
QQ
F
R
-----------
QQA
R
FGERMGEASRSHYMAR
MQ
TL
R
L
D
G
F
LL
R
P
L
L
S
L
FS
SL
I
L
CG
LL
M
L
F
G
F
S
---
A
S
G
TIE
V
G
V
L
Y
A
F
I
SYLG
R
L
NE
PL
IE
LT
TQ
-------
Q
A
ML
Q
Q
AV
V
A
GERV
F
E
L
M
DG
P
R
QQ
-----
Y
GNDD
R
PLQ
S
GT
-
-
I
E
VD
NV
S
F
A
Y
-
RD
D
N
LV
LKNINL
S
V
P
S
R
NF
VALVG
H
TGSGKSTLASL
L
M
G
YY
P
L
T
EGEIR
L
DG
R
PL
SS
L
S
H
S
A
LR
QG
VAMV
Q
Q
D
P
V
VL
ADT
FLA
N
VT
LG
-
-RDI
SEER
VW
Q
A
LE
T
V
QLA
E
L
A
RS
M
SD
G
I
Y
T
P
LGE
Q
G
N
N
LS
V
GQKQ
LL
A
L
AR
V
L
V
ETPQ
ILILDEAT
AS
ID
SG
TE
Q
AIQHAL
AAVR
E
H
T
T
L
V
VIAHRLSTI
V
DAD
T
I
L
VL
HR
G
Q
A
VE
Q
GTH
QQ
LL
AAQ
G
R
Y
W
QMYQ
L
Q
LA
GEELAASVR
E
EESLSA
fig|585055.8.peg.472
Escherichia coli 55989
MRSFSQLW
P
T
LK
RL
LAYGSP
W
--------
-
R
KPL
G
I
A
V
LMM
WV
A
AAA-
--
E
V
SG
P
LLISYFI
D
N
MVAKNN
L
PLK
M
V
A
G
LA
AA
Y
VGL
QL
FAAG
L
----
---
-
--H
Y
AQ
S
L
L
FNR
A
AVG
VV
QQ
LR
T
D
VMDAAL
RQP
L
S
E
FD
T
Q
P
V
G
Q
V
ISR
V
TND
T
E
VIRDLYV
T
VV
A-------
TV
L
R
SA
ALV
G
A
---
M
L
V
A
MF
SL
D
W
RM
---
A
L
V
A
I
M
I
F
PVV
LV
VMVIYQ
R
YSTP
IV
R
RVR
A
YLA
D
I
ND
----
G
FNE
I
IN
G
MSV
I
QQ
F
R
-----------
QQA
R
FGERMGEASRSHYMAR
MQ
TL
R
L
D
G
F
LL
R
P
L
L
S
L
FS
SL
I
L
CG
LL
M
L
F
G
F
S
---
A
S
G
TIE
V
G
V
L
Y
A
F
I
SYLG
R
L
NE
PL
IE
LT
TQ
-------
Q
A
ML
Q
Q
AV
V
A
GERV
F
E
L
M
DG
P
R
QQ
-----
Y
GNDD
R
PLQ
S
GT
-
-
I
E
VD
NV
S
F
A
Y
-
RD
D
N
LV
LKNINL
S
V
P
S
R
NF
VALVG
H
TGSGKSTLASL
L
M
G
YY
P
L
T
EGEIR
L
DG
R
PL
SS
L
S
H
S
A
LR
QG
VAMV
Q
Q
D
P
V
VL
ADT
FLA
N
VT
LG
-
-RDI
SEER
VW
Q
A
LE
T
V
QLA
E
L
A
RS
M
SD
G
I
Y
T
P
LGE
Q
G
N
N
LS
V
GQKQ
LL
A
L
AR
V
L
V
ETPQ
ILILDEAT
AS
ID
SG
TE
Q
AIQHAL
AAVR
E
H
T
T
L
V
VIAHRLSTI
V
DAD
T
I
L
VL
HR
G
Q
A
VE
Q
GTH
QQ
LL
AAQ
G
R
Y
W
QMYQ
L
Q
LA
GEELAASVR
E
EESLSA
fig|413997.3.peg.431
Escherichia coli B str. REL606
MRSFSQLW
P
T
LK
RL
LAYGSP
W
--------
-
R
KPL
G
I
A
V
LMM
WV
A
AAA-
--
E
V
SG
P
LLISYFI
D
N
MVAKNN
L
PLK
M
V
A
G
LA
AA
Y
VGL
QL
FAAG
L
----
---
-
--H
Y
AQ
S
L
L
FNR
A
AVG
VV
QQ
LR
T
D
VMDAAL
RQP
L
S
E
FD
T
Q
P
V
G
Q
V
ISR
V
TND
T
E
VIRDLYV
T
VV
A-------
TV
L
R
SA
ALV
G
A
---
M
L
V
A
MF
SL
D
W
RM
---
A
L
V
A
I
M
I
F
PVV
LV
VMVIYQ
R
YSTP
IV
R
RVR
A
YLA
D
I
ND
----
G
FNE
I
IN
G
MSV
I
QQ
F
R
-----------
QQA
R
FGERMGEASRSHYMAR
MQ
TL
R
L
D
G
F
LL
R
P
L
L
S
L
FS
SL
I
L
CG
LL
M
L
F
G
F
S
---
A
S
G
TIE
V
G
V
L
Y
A
F
I
SYLG
R
L
NE
PL
IE
LT
TQ
-------
Q
A
ML
Q
Q
AV
V
A
GERV
F
E
L
M
DG
P
R
QQ
-----
Y
GNDD
R
PLQ
S
GT
-
-
I
E
VD
NV
S
F
A
Y
-
RD
D
N
LV
LKNINL
S
V
P
S
R
NF
VALVG
H
TGSGKSTLASL
L
M
G
YY
P
L
T
EGEIR
L
DG
R
PL
SS
L
S
H
S
A
LR
QG
VAMV
Q
Q
D
P
V
VL
ADT
FLA
N
VT
LG
-
-RDI
SEER
VW
Q
A
LE
T
V
QLA
E
L
A
RS
M
SD
G
I
Y
T
P
LGE
Q
G
N
N
LS
V
GQKQ
LL
A
L
AR
V
L
V
ETPQ
ILILDEAT
AS
ID
SG
TE
Q
AIQHAL
AAVR
E
H
T
T
L
V
VIAHRLSTI
V
DAD
T
I
L
VL
HR
G
Q
A
VE
Q
GTH
QQ
LL
AAQ
G
R
Y
W
QMYQ
L
Q
LA
GEELAASVR
E
EESLSA
fig|344601.3.peg.3355
Escherichia coli B171
MRSFSQLW
P
T
LK
RL
LAYGSP
W
--------
-
R
KPL
G
I
A
V
LMM
WV
A
AAA-
--
E
V
SG
P
LLISYFI
D
N
MVAKNN
L
PLK
M
V
A
G
LA
AA
Y
VGL
QL
FAAG
L
----
---
-
--H
Y
AQ
S
L
L
FNR
A
AVG
VV
QQ
LR
T
D
VMDAAL
RQP
L
S
E
FD
T
Q
P
V
G
Q
V
ISR
V
TND
T
E
VIRDLYV
T
VV
A-------
TV
L
R
SA
ALV
G
A
---
M
L
V
A
MF
SL
D
W
RM
---
A
L
V
A
I
M
I
F
PVV
LV
VMVIYQ
R
YSTP
IV
R
RVR
A
YLA
D
I
ND
----
G
FNE
I
IN
G
MSV
I
QQ
F
R
-----------
QQA
R
FGERMGEASRSHYMAR
MQ
TL
R
L
D
G
F
LL
R
P
L
L
S
L
FS
SL
I
L
CG
LL
M
L
F
G
F
S
---
A
S
G
TIE
V
G
V
L
Y
A
F
I
SYLG
R
L
NE
PL
IE
LT
TQ
-------
Q
A
ML
Q
Q
AV
V
A
GERV
F
E
L
M
DG
P
R
QQ
-----
Y
GNDD
R
PLQ
S
GT
-
-
I
E
VD
NV
S
F
A
Y
-
RD
D
N
LV
LKNINL
S
V
P
S
R
NF
VALVG
H
TGSGKSTLASL
L
M
G
YY
P
L
T
EGEIR
L
DG
R
PL
SS
L
S
H
S
A
LR
QG
VAMV
Q
Q
D
P
V
VL
ADT
FLA
N
VT
LG
-
-RDI
SEER
VW
Q
A
LE
T
V
QLA
E
L
A
RS
M
SD
G
I
Y
T
P
LGE
Q
G
N
N
LS
V
GQKQ
LL
A
L
AR
V
L
V
ETPQ
ILILDEAT
AS
ID
SG
TE
Q
AIQHAL
AAVR
E
H
T
T
L
V
VIAHRLSTI
V
DAD
T
I
L
VL
HR
G
Q
A
VE
Q
GTH
QQ
LL
AAQ
G
R
Y
W
QMYQ
L
Q
LA
GEELAASVR
E
EESLSA
fig|344601.5.peg.3510
Escherichia coli B171
MRSFSQLW
P
T
LK
RL
LAYGSP
W
--------
-
R
KPL
G
I
A
V
LMM
WV
A
AAA-
--
E
V
SG
P
LLISYFI
D
N
MVAKNN
L
PLK
M
V
A
G
LA
AA
Y
VGL
QL
FAAG
L
----
---
-
--H
Y
AQ
S
L
L
FNR
A
AVG
VV
QQ
LR
T
D
VMDAAL
RQP
L
S
E
FD
T
Q
P
V
G
Q
V
ISR
V
TND
T
E
VIRDLYV
T
VV
A-------
TV
L
R
SA
ALV
G
A
---
M
L
V
A
MF
SL
D
W
RM
---
A
L
V
A
I
M
I
F
PVV
LV
VMVIYQ
R
YSTP
IV
R
RVR
A
YLA
D
I
ND
----
G
FNE
I
IN
G
MSV
I
QQ
F
R
-----------
QQA
R
FGERMGEASRSHYMAR
MQ
TL
R
L
D
G
F
LL
R
P
L
L
S
L
FS
SL
I
L
CG
LL
M
L
F
G
F
S
---
A
S
G
TIE
V
G
V
L
Y
A
F
I
SYLG
R
L
NE
PL
IE
LT
TQ
-------
Q
A
ML
Q
Q
AV
V
A
GERV
F
E
L
M
DG
P
R
QQ
-----
Y
GNDD
R
PLQ
S
GT
-
-
I
E
VD
NV
S
F
A
Y
-
RD
D
N
LV
LKNINL
S
V
P
S
R
NF
VALVG
H
TGSGKSTLASL
L
M
G
YY
P
L
T
EGEIR
L
DG
R
PL
SS
L
S
H
S
A
LR
QG
VAMV
Q
Q
D
P
V
VL
ADT
FLA
N
VT
LG
-
-RDI
SEER
VW
Q
A
LE
T
V
QLA
E
L
A
RS
M
SD
G
I
Y
T
P
LGE
Q
G
N
N
LS
V
GQKQ
LL
A
L
AR
V
L
V
ETPQ
ILILDEAT
AS
ID
SG
TE
Q
AIQHAL
AAVR
E
H
T
T
L
V
VIAHRLSTI
V
DAD
T
I
L
VL
HR
G
Q
A
VE
Q
GTH
QQ
LL
AAQ
G
R
Y
W
QMYQ
L
Q
LA
GEELAASVR
E
EESLSA
fig|340184.3.peg.3336
Escherichia coli B7A
MRSFSQLW
P
T
LK
RL
LAYGSP
W
--------
-
R
KPL
G
I
A
V
LMM
WV
A
AAA-
--
E
V
SG
P
LLISYFI
D
N
MVAKNN
L
PLK
M
V
A
G
LA
AA
Y
VGL
QL
FAAG
L
----
---
-
--H
Y
AQ
S
L
L
FNR
A
AVG
VV
QQ
LR
T
D
VMDAAL
RQP
L
S
E
FD
T
Q
P
V
G
Q
V
ISR
V
TND
T
E
VIRDLYV
T
VV
A-------
TV
L
R
SA
ALV
G
A
---
M
L
V
A
MF
SL
D
W
RM
---
A
L
V
A
I
M
I
F
PVV
LV
VMVIYQ
R
YSTP
IV
R
RVR
A
YLA
D
I
ND
----
G
FNE
I
IN
G
MSV
I
QQ
F
R
-----------
QQA
R
FGERMGEASRSHYMAR
MQ
TL
R
L
D
G
F
LL
R
P
L
L
S
L
FS
SL
I
L
CG
LL
M
L
F
G
F
S
---
A
S
G
TIE
V
G
V
L
Y
A
F
I
SYLG
R
L
NE
PL
IE
LT
TQ
-------
Q
A
ML
Q
Q
AV
V
A
GERV
F
E
L
M
DG
P
R
QQ
-----
Y
GNDD
R
PLQ
S
GT
-
-
I
E
VD
NV
S
F
A
Y
-
RD
D
N
LV
LKNINL
S
V
P
S
R
NF
VALVG
H
TGSGKSTLASL
L
M
G
YY
P
L
T
EGEIR
L
DG
R
PL
SS
L
S
H
S
A
LR
QG
VAMV
Q
Q
D
P
V
VL
ADT
FLA
N
VT
LG
-
-RDI
SEER
VW
Q
A
LE
T
V
QLA
E
L
A
RS
M
SD
G
I
Y
T
P
LGE
Q
G
N
N
LS
V
GQKQ
LL
A
L
AR
V
L
V
ETPQ
ILILDEAT
AS
ID
SG
TE
Q
AIQHAL
AAVR
E
H
T
T
L
V
VIAHRLSTI
V
DAD
T
I
L
VL
HR
G
Q
A
VE
Q
GTH
QQ
LL
AAQ
G
R
Y
W
QMYQ
L
Q
LA
GEELAASVR
E
EESLSA
fig|340184.6.peg.3482
Escherichia coli B7A
MRSFSQLW
P
T
LK
RL
LAYGSP
W
--------
-
R
KPL
G
I
A
V
LMM
WV
A
AAA-
--
E
V
SG
P
LLISYFI
D
N
MVAKNN
L
PLK
M
V
A
G
LA
AA
Y
VGL
QL
FAAG
L
----
---
-
--H
Y
AQ
S
L
L
FNR
A
AVG
VV
QQ
LR
T
D
VMDAAL
RQP
L
S
E
FD
T
Q
P
V
G
Q
V
ISR
V
TND
T
E
VIRDLYV
T
VV
A-------
TV
L
R
SA
ALV
G
A
---
M
L
V
A
MF
SL
D
W
RM
---
A
L
V
A
I
M
I
F
PVV
LV
VMVIYQ
R
YSTP
IV
R
RVR
A
YLA
D
I
ND
----
G
FNE
I
IN
G
MSV
I
QQ
F
R
-----------
QQA
R
FGERMGEASRSHYMAR
MQ
TL
R
L
D
G
F
LL
R
P
L
L
S
L
FS
SL
I
L
CG
LL
M
L
F
G
F
S
---
A
S
G
TIE
V
G
V
L
Y
A
F
I
SYLG
R
L
NE
PL
IE
LT
TQ
-------
Q
A
ML
Q
Q
AV
V
A
GERV
F
E
L
M
DG
P
R
QQ
-----
Y
GNDD
R
PLQ
S
GT
-
-
I
E
VD
NV
S
F
A
Y
-
RD
D
N
LV
LKNINL
S
V
P
S
R
NF
VALVG
H
TGSGKSTLASL
L
M
G
YY
P
L
T
EGEIR
L
DG
R
PL
SS
L
S
H
S
A
LR
QG
VAMV
Q
Q
D
P
V
VL
ADT
FLA
N
VT
LG
-
-RDI
SEER
VW
Q
A
LE
T
V
QLA
E
L
A
RS
M
SD
G
I
Y
T
P
LGE
Q
G
N
N
LS
V
GQKQ
LL
A
L
AR
V
L
V
ETPQ
ILILDEAT
AS
ID
SG
TE
Q
AIQHAL
AAVR
E
H
T
T
L
V
VIAHRLSTI
V
DAD
T
I
L
VL
HR
G
Q
A
VE
Q
GTH
QQ
LL
AAQ
G
R
Y
W
QMYQ
L
Q
LA
GEELAASVR
E
EESLSA
fig|511693.5.peg.435
Escherichia coli BL21
MRSFSQLW
P
T
LK
RL
LAYGSP
W
--------
-
R
KPL
G
I
A
V
LMM
WV
A
AAA-
--
E
V
SG
P
LLISYFI
D
N
MVAKNN
L
PLK
M
V
A
G
LA
AA
Y
VGL
QL
FAAG
L
----
---
-
--H
Y
AQ
S
L
L
FNR
A
AVG
VV
QQ
LR
T
D
VMDAAL
RQP
L
S
E
FD
T
Q
P
V
G
Q
V
ISR
V
TND
T
E
VIRDLYV
T
VV
A-------
TV
L
R
SA
ALV
G
A
---
M
L
V
A
MF
SL
D
W
RM
---
A
L
V
A
I
M
I
F
PVV
LV
VMVIYQ
R
YSTP
IV
R
RVR
A
YLA
D
I
ND
----
G
FNE
I
IN
G
MSV
I
QQ
F
R
-----------
QQA
R
FGERMGEASRSHYMAR
MQ
TL
R
L
D
G
F
LL
R
P
L
L
S
L
FS
SL
I
L
CG
LL
M
L
F
G
F
S
---
A
S
G
TIE
V
G
V
L
Y
A
F
I
SYLG
R
L
NE
PL
IE
LT
TQ
-------
Q
A
ML
Q
Q
AV
V
A
GERV
F
E
L
M
DG
P
R
QQ
-----
Y
GNDD
R
PLQ
S
GT
-
-
I
E
VD
NV
S
F
A
Y
-
RD
D
N
LV
LKNINL
S
V
P
S
R
NF
VALVG
H
TGSGKSTLASL
L
M
G
YY
P
L
T
EGEIR
L
DG
R
PL
SS
L
S
H
S
A
LR
QG
VAMV
Q
Q
D
P
V
VL
ADT
FLA
N
VT
LG
-
-RDI
SEER
VW
Q
A
LE
T
V
QLA
E
L
A
RS
M
SD
G
I
Y
T
P
LGE
Q
G
N
N
LS
V
GQKQ
LL
A
L
AR
V
L
V
ETPQ
ILILDEAT
AS
ID
SG
TE
Q
AIQHAL
AAVR
E
H
T
T
L
V
VIAHRLSTI
V
DAD
T
I
L
VL
HR
G
Q
A
VE
Q
GTH
QQ
LL
AAQ
G
R
Y
W
QMYQ
L
Q
LA
GEELAASVR
E
EESLSA
fig|469008.4.peg.3314
Escherichia coli BL21(DE3)
MRSFSQLW
P
T
LK
RL
LAYGSP
W
--------
-
R
KPL
G
I
A
V
LMM
WV
A
AAA-
--
E
V
SG
P
LLISYFI
D
N
MVAKNN
L
PLK
M
V
A
G
LA
AA
Y
VGL
QL
FAAG
L
----
---
-
--H
Y
AQ
S
L
L
FNR
A
AVG
VV
QQ
LR
T
D
VMDAAL
RQP
L
S
E
FD
T
Q
P
V
G
Q
V
ISR
V
TND
T
E
VIRDLYV
T
VV
A-------
TV
L
R
SA
ALV
G
A
---
M
L
V
A
MF
SL
D
W
RM
---
A
L
V
A
I
M
I
F
PVV
LV
VMVIYQ
R
YSTP
IV
R
RVR
A
YLA
D
I
ND
----
G
FNE
I
IN
G
MSV
I
QQ
F
R
-----------
QQA
R
FGERMGEASRSHYMAR
MQ
TL
R
L
D
G
F
LL
R
P
L
L
S
L
FS
SL
I
L
CG
LL
M
L
F
G
F
S
---
A
S
G
TIE
V
G
V
L
Y
A
F
I
SYLG
R
L
NE
PL
IE
LT
TQ
-------
Q
A
ML
Q
Q
AV
V
A
GERV
F
E
L
M
DG
P
R
QQ
-----
Y
GNDD
R
PLQ
S
GT
-
-
I
E
VD
NV
S
F
A
Y
-
RD
D
N
LV
LKNINL
S
V
P
S
R
NF
VALVG
H
TGSGKSTLASL
L
M
G
YY
P
L
T
EGEIR
L
DG
R
PL
SS
L
S
H
S
A
LR
QG
VAMV
Q
Q
D
P
V
VL
ADT
FLA
N
VT
LG
-
-RDI
SEER
VW
Q
A
LE
T
V
QLA
E
L
A
RS
M
SD
G
I
Y
T
P
LGE
Q
G
N
N
LS
V
GQKQ
LL
A
L
AR
V
L
V
ETPQ
ILILDEAT
AS
ID
SG
TE
Q
AIQHAL
AAVR
E
H
T
T
L
V
VIAHRLSTI
V
DAD
T
I
L
VL
HR
G
Q
A
VE
Q
GTH
QQ
LL
AAQ
G
R
Y
W
QMYQ
L
Q
LA
GEELAASVR
E
EESLSA
fig|340186.3.peg.888
Escherichia coli E110019
MRSFSQLW
P
T
LK
RL
LAYGSP
W
--------
-
R
KPL
G
I
A
V
LMM
WV
A
AAA-
--
E
V
SG
P
LLISYFI
D
N
MVAKNN
L
PLK
M
V
A
G
LA
AA
Y
VGL
QL
FAAG
L
----
---
-
--H
Y
AQ
S
L
L
FNR
A
AVG
VV
QQ
LR
T
D
VMDAAL
RQP
L
S
E
FD
T
Q
P
V
G
Q
V
ISR
V
TND
T
E
VIRDLYV
T
VV
A-------
TV
L
R
SA
ALV
G
A
---
M
L
V
A
MF
SL
D
W
RM
---
A
L
V
A
I
M
I
F
PVV
LV
VMVIYQ
R
YSTP
IV
R
RVR
A
YLA
D
I
ND
----
G
FNE
I
IN
G
MSV
I
QQ
F
R
-----------
QQA
R
FGERMGEASRSHYMAR
MQ
TL
R
L
D
G
F
LL
R
P
L
L
S
L
FS
SL
I
L
CG
LL
M
L
F
G
F
S
---
A
S
G
TIE
V
G
V
L
Y
A
F
I
SYLG
R
L
NE
PL
IE
LT
TQ
-------
Q
A
ML
Q
Q
AV
V
A
GERV
F
E
L
M
DG
P
R
QQ
-----
Y
GNDD
R
PLQ
S
GT
-
-
I
E
VD
NV
S
F
A
Y
-
RD
D
N
LV
LKNINL
S
V
P
S
R
NF
VALVG
H
TGSGKSTLASL
L
M
G
YY
P
L
T
EGEIR
L
DG
R
PL
SS
L
S
H
S
A
LR
QG
VAMV
Q
Q
D
P
V
VL
ADT
FLA
N
VT
LG
-
-RDI
SEER
VW
Q
A
LE
T
V
QLA
E
L
A
RS
M
SD
G
I
Y
T
P
LGE
Q
G
N
N
LS
V
GQKQ
LL
A
L
AR
V
L
V
ETPQ
ILILDEAT
AS
ID
SG
TE
Q
AIQHAL
AAVR
E
H
T
T
L
V
VIAHRLSTI
V
DAD
T
I
L
VL
HR
G
Q
A
VE
Q
GTH
QQ
LL
AAQ
G
R
Y
W
QMYQ
L
Q
LA
GEELAASVR
E
EESLSA
fig|340186.5.peg.928
Escherichia coli E110019
MRSFSQLW
P
T
LK
RL
LAYGSP
W
--------
-
R
KPL
G
I
A
V
LMM
WV
A
AAA-
--
E
V
SG
P
LLISYFI
D
N
MVAKNN
L
PLK
M
V
A
G
LA
AA
Y
VGL
QL
FAAG
L
----
---
-
--H
Y
AQ
S
L
L
FNR
A
AVG
VV
QQ
LR
T
D
VMDAAL
RQP
L
S
E
FD
T
Q
P
V
G
Q
V
ISR
V
TND
T
E
VIRDLYV
T
VV
A-------
TV
L
R
SA
ALV
G
A
---
M
L
V
A
MF
SL
D
W
RM
---
A
L
V
A
I
M
I
F
PVV
LV
VMVIYQ
R
YSTP
IV
R
RVR
A
YLA
D
I
ND
----
G
FNE
I
IN
G
MSV
I
QQ
F
R
-----------
QQA
R
FGERMGEASRSHYMAR
MQ
TL
R
L
D
G
F
LL
R
P
L
L
S
L
FS
SL
I
L
CG
LL
M
L
F
G
F
S
---
A
S
G
TIE
V
G
V
L
Y
A
F
I
SYLG
R
L
NE
PL
IE
LT
TQ
-------
Q
A
ML
Q
Q
AV
V
A
GERV
F
E
L
M
DG
P
R
QQ
-----
Y
GNDD
R
PLQ
S
GT
-
-
I
E
VD
NV
S
F
A
Y
-
RD
D
N
LV
LKNINL
S
V
P
S
R
NF
VALVG
H
TGSGKSTLASL
L
M
G
YY
P
L
T
EGEIR
L
DG
R
PL
SS
L
S
H
S
A
LR
QG
VAMV
Q
Q
D
P
V
VL
ADT
FLA
N
VT
LG
-
-RDI
SEER
VW
Q
A
LE
T
V
QLA
E
L
A
RS
M
SD
G
I
Y
T
P
LGE
Q
G
N
N
LS
V
GQKQ
LL
A
L
AR
V
L
V
ETPQ
ILILDEAT
AS
ID
SG
TE
Q
AIQHAL
AAVR
E
H
T
T
L
V
VIAHRLSTI
V
DAD
T
I
L
VL
HR
G
Q
A
VE
Q
GTH
QQ
LL
AAQ
G
R
Y
W
QMYQ
L
Q
LA
GEELAASVR
E
EESLSA
fig|340185.3.peg.2564
Escherichia coli E22
MRSFSQLW
P
T
LK
RL
LAYGSP
W
--------
-
R
KPL
G
I
A
V
LMM
WV
A
AAA-
--
E
V
SG
P
LLISYFI
D
N
MVAKNN
L
PLK
M
V
A
G
LA
AA
Y
VGL
QL
FAAG
L
----
---
-
--H
Y
AQ
S
L
L
FNR
A
AVG
VV
QQ
LR
T
D
VMDAAL
RQP
L
S
E
FD
T
Q
P
V
G
Q
V
ISR
V
TND
T
E
VIRDLYV
T
VV
A-------
TV
L
R
SA
ALV
G
A
---
M
L
V
A
MF
SL
D
W
RM
---
A
L
V
A
I
M
I
F
PVV
LV
VMVIYQ
R
YSTP
IV
R
RVR
A
YLA
D
I
ND
----
G
FNE
I
IN
G
MSV
I
QQ
F
R
-----------
QQA
R
FGERMGEASRSHYMAR
MQ
TL
R
L
D
G
F
LL
R
P
L
L
S
L
FS
SL
I
L
CG
LL
M
L
F
G
F
S
---
A
S
G
TIE
V
G
V
L
Y
A
F
I
SYLG
R
L
NE
PL
IE
LT
TQ
-------
Q
A
ML
Q
Q
AV
V
A
GERV
F
E
L
M
DG
P
R
QQ
-----
Y
GNDD
R
PLQ
S
GT
-
-
I
E
VD
NV
S
F
A
Y
-
RD
D
N
LV
LKNINL
S
V
P
S
R
NF
VALVG
H
TGSGKSTLASL
L
M
G
YY
P
L
T
EGEIR
L
DG
R
PL
SS
L
S
H
S
A
LR
QG
VAMV
Q
Q
D
P
V
VL
ADT
FLA
N
VT
LG
-
-RDI
SEER
VW
Q
A
LE
T
V
QLA
E
L
A
RS
M
SD
G
I
Y
T
P
LGE
Q
G
N
N
LS
V
GQKQ
LL
A
L
AR
V
L
V
ETPQ
ILILDEAT
AS
ID
SG
TE
Q
AIQHAL
AAVR
E
H
T
T
L
V
VIAHRLSTI
V
DAD
T
I
L
VL
HR
G
Q
A
VE
Q
GTH
QQ
LL
AAQ
G
R
Y
W
QMYQ
L
Q
LA
GEELAASVR
E
EESLSA
fig|340185.4.peg.2706
Escherichia coli E22
MRSFSQLW
P
T
LK
RL
LAYGSP
W
--------
-
R
KPL
G
I
A
V
LMM
WV
A
AAA-
--
E
V
SG
P
LLISYFI
D
N
MVAKNN
L
PLK
M
V
A
G
LA
AA
Y
VGL
QL
FAAG
L
----
---
-
--H
Y
AQ
S
L
L
FNR
A
AVG
VV
QQ
LR
T
D
VMDAAL
RQP
L
S
E
FD
T
Q
P
V
G
Q
V
ISR
V
TND
T
E
VIRDLYV
T
VV
A-------
TV
L
R
SA
ALV
G
A
---
M
L
V
A
MF
SL
D
W
RM
---
A
L
V
A
I
M
I
F
PVV
LV
VMVIYQ
R
YSTP
IV
R
RVR
A
YLA
D
I
ND
----
G
FNE
I
IN
G
MSV
I
QQ
F
R
-----------
QQA
R
FGERMGEASRSHYMAR
MQ
TL
R
L
D
G
F
LL
R
P
L
L
S
L
FS
SL
I
L
CG
LL
M
L
F
G
F
S
---
A
S
G
TIE
V
G
V
L
Y
A
F
I
SYLG
R
L
NE
PL
IE
LT
TQ
-------
Q
A
ML
Q
Q
AV
V
A
GERV
F
E
L
M
DG
P
R
QQ
-----
Y
GNDD
R
PLQ
S
GT
-
-
I
E
VD
NV
S
F
A
Y
-
RD
D
N
LV
LKNINL
S
V
P
S
R
NF
VALVG
H
TGSGKSTLASL
L
M
G
YY
P
L
T
EGEIR
L
DG
R
PL
SS
L
S
H
S
A
LR
QG
VAMV
Q
Q
D
P
V
VL
ADT
FLA
N
VT
LG
-
-RDI
SEER
VW
Q
A
LE
T
V
QLA
E
L
A
RS
M
SD
G
I
Y
T
P
LGE
Q
G
N
N
LS
V
GQKQ
LL
A
L
AR
V
L
V
ETPQ
ILILDEAT
AS
ID
SG
TE
Q
AIQHAL
AAVR
E
H
T
T
L
V
VIAHRLSTI
V
DAD
T
I
L
VL
HR
G
Q
A
VE
Q
GTH
QQ
LL
AAQ
G
R
Y
W
QMYQ
L
Q
LA
GEELAASVR
E
EESLSA
fig|331111.12.peg.793
Escherichia coli E24377A
MRSFSQLW
P
T
LK
RL
LAYGSP
W
--------
-
R
KPL
G
I
A
V
LMM
WV
A
AAA-
--
E
V
SG
P
LLISYFI
D
N
MVAKNN
L
PLK
M
V
A
G
LA
AA
Y
VGL
QL
FAAG
L
----
---
-
--H
Y
AQ
S
L
L
FNR
A
AVG
VV
QQ
LR
T
D
VMDAAL
RQP
L
S
E
FD
T
Q
P
V
G
Q
V
ISR
V
TND
T
E
VIRDLYV
T
VV
A-------
TV
L
R
SA
ALV
G
A
---
M
L
V
A
MF
SL
D
W
RM
---
A
L
V
A
I
M
I
F
PVV
LV
VMVIYQ
R
YSTP
IV
R
RVR
A
YLA
D
I
ND
----
G
FNE
I
IN
G
MSV
I
QQ
F
R
-----------
QQA
R
FGERMGEASRSHYMAR
MQ
TL
R
L
D
G
F
LL
R
P
L
L
S
L
FS
SL
I
L
CG
LL
M
L
F
G
F
S
---
A
S
G
TIE
V
G
V
L
Y
A
F
I
SYLG
R
L
NE
PL
IE
LT
TQ
-------
Q
A
ML
Q
Q
AV
V
A
GERV
F
E
L
M
DG
P
R
QQ
-----
Y
GNDD
R
PLQ
S
GT
-
-
I
E
VD
NV
S
F
A
Y
-
RD
D
N
LV
LKNINL
S
V
P
S
R
NF
VALVG
H
TGSGKSTLASL
L
M
G
YY
P
L
T
EGEIR
L
DG
R
PL
SS
L
S
H
S
A
LR
QG
VAMV
Q
Q
D
P
V
VL
ADT
FLA
N
VT
LG
-
-RDI
SEER
VW
Q
A
LE
T
V
QLA
E
L
A
RS
M
SD
G
I
Y
T
P
LGE
Q
G
N
N
LS
V
GQKQ
LL
A
L
AR
V
L
V
ETPQ
ILILDEAT
AS
ID
SG
TE
Q
AIQHAL
AAVR
E
H
T
T
L
V
VIAHRLSTI
V
DAD
T
I
L
VL
HR
G
Q
A
VE
Q
GTH
QQ
LL
AAQ
G
R
Y
W
QMYQ
L
Q
LA
GEELAASVR
E
EESLSA
fig|331111.3.peg.3024
Escherichia coli E24377A
MRSFSQLW
P
T
LK
RL
LAYGSP
W
--------
-
R
KPL
G
I
A
V
LMM
WV
A
AAA-
--
E
V
SG
P
LLISYFI
D
N
MVAKNN
L
PLK
M
V
A
G
LA
AA
Y
VGL
QL
FAAG
L
----
---
-
--H
Y
AQ
S
L
L
FNR
A
AVG
VV
QQ
LR
T
D
VMDAAL
RQP
L
S
E
FD
T
Q
P
V
G
Q
V
ISR
V
TND
T
E
VIRDLYV
T
VV
A-------
TV
L
R
SA
ALV
G
A
---
M
L
V
A
MF
SL
D
W
RM
---
A
L
V
A
I
M
I
F
PVV
LV
VMVIYQ
R
YSTP
IV
R
RVR
A
YLA
D
I
ND
----
G
FNE
I
IN
G
MSV
I
QQ
F
R
-----------
QQA
R
FGERMGEASRSHYMAR
MQ
TL
R
L
D
G
F
LL
R
P
L
L
S
L
FS
SL
I
L
CG
LL
M
L
F
G
F
S
---
A
S
G
TIE
V
G
V
L
Y
A
F
I
SYLG
R
L
NE
PL
IE
LT
TQ
-------
Q
A
ML
Q
Q
AV
V
A
GERV
F
E
L
M
DG
P
R
QQ
-----
Y
GNDD
R
PLQ
S
GT
-
-
I
E
VD
NV
S
F
A
Y
-
RD
D
N
LV
LKNINL
S
V
P
S
R
NF
VALVG
H
TGSGKSTLASL
L
M
G
YY
P
L
T
EGEIR
L
DG
R
PL
SS
L
S
H
S
A
LR
QG
VAMV
Q
Q
D
P
V
VL
ADT
FLA
N
VT
LG
-
-RDI
SEER
VW
Q
A
LE
T
V
QLA
E
L
A
RS
M
SD
G
I
Y
T
P
LGE
Q
G
N
N
LS
V
GQKQ
LL
A
L
AR
V
L
V
ETPQ
ILILDEAT
AS
ID
SG
TE
Q
AIQHAL
AAVR
E
H
T
T
L
V
VIAHRLSTI
V
DAD
T
I
L
VL
HR
G
Q
A
VE
Q
GTH
QQ
LL
AAQ
G
R
Y
W
QMYQ
L
Q
LA
GEELAASVR
E
EESLSA
fig|656408.3.peg.389
Escherichia coli H591
MRSFSQLW
P
T
LK
RL
LAYGSP
W
--------
-
R
KPL
G
I
A
V
LMM
WV
A
AAA-
--
E
V
SG
P
LLISYFI
D
N
MVAKNN
L
PLK
M
V
A
G
LA
AA
Y
VGL
QL
FAAG
L
----
---
-
--H
Y
AQ
S
L
L
FNR
A
AVG
VV
QQ
LR
T
D
VMDAAL
RQP
L
S
E
FD
T
Q
P
V
G
Q
V
ISR
V
TND
T
E
VIRDLYV
T
VV
A-------
TV
L
R
SA
ALV
G
A
---
M
L
V
A
MF
SL
D
W
RM
---
A
L
V
A
I
M
I
F
PVV
LV
VMVIYQ
R
YSTP
IV
R
RVR
A
YLA
D
I
ND
----
G
FNE
I
IN
G
MSV
I
QQ
F
R
-----------
QQA
R
FGERMGEASRSHYMAR
MQ
TL
R
L
D
G
F
LL
R
P
L
L
S
L
FS
SL
I
L
CG
LL
M
L
F
G
F
S
---
A
S
G
TIE
V
G
V
L
Y
A
F
I
SYLG
R
L
NE
PL
IE
LT
TQ
-------
Q
A
ML
Q
Q
AV
V
A
GERV
F
E
L
M
DG
P
R
QQ
-----
Y
GNDD
R
PLQ
S
GT
-
-
I
E
VD
NV
S
F
A
Y
-
RD
D
N
LV
LKNINL
S
V
P
S
R
NF
VALVG
H
TGSGKSTLASL
L
M
G
YY
P
L
T
EGEIR
L
DG
R
PL
SS
L
S
H
S
A
LR
QG
VAMV
Q
Q
D
P
V
VL
ADT
FLA
N
VT
LG
-
-RDI
SEER
VW
Q
A
LE
T
V
QLA
E
L
A
RS
M
SD
G
I
Y
T
P
LGE
Q
G
N
N
LS
V
GQKQ
LL
A
L
AR
V
L
V
ETPQ
ILILDEAT
AS
ID
SG
TE
Q
AIQHAL
AAVR
E
H
T
T
L
V
VIAHRLSTI
V
DAD
T
I
L
VL
HR
G
Q
A
VE
Q
GTH
QQ
LL
AAQ
G
R
Y
W
QMYQ
L
Q
LA
GEELAASVR
E
EESLSA
fig|679206.4.peg.99
Escherichia coli MS 119-7
MRSFSQLW
P
T
LK
RL
LAYGSP
W
--------
-
R
KPL
G
I
A
V
LMM
WV
A
AAA-
--
E
V
SG
P
LLISYFI
D
N
MVAKNN
L
PLK
M
V
A
G
LA
AA
Y
VGL
QL
FAAG
L
----
---
-
--H
Y
AQ
S
L
L
FNR
A
AVG
VV
QQ
LR
T
D
VMDAAL
RQP
L
S
E
FD
T
Q
P
V
G
Q
V
ISR
V
TND
T
E
VIRDLYV
T
VV
A-------
TV
L
R
SA
ALV
G
A
---
M
L
V
A
MF
SL
D
W
RM
---
A
L
V
A
I
M
I
F
PVV
LV
VMVIYQ
R
YSTP
IV
R
RVR
A
YLA
D
I
ND
----
G
FNE
I
IN
G
MSV
I
QQ
F
R
-----------
QQA
R
FGERMGEASRSHYMAR
MQ
TL
R
L
D
G
F
LL
R
P
L
L
S
L
FS
SL
I
L
CG
LL
M
L
F
G
F
S
---
A
S
G
TIE
V
G
V
L
Y
A
F
I
SYLG
R
L
NE
PL
IE
LT
TQ
-------
Q
A
ML
Q
Q
AV
V
A
GERV
F
E
L
M
DG
P
R
QQ
-----
Y
GNDD
R
PLQ
S
GT
-
-
I
E
VD
NV
S
F
A
Y
-
RD
D
N
LV
LKNINL
S
V
P
S
R
NF
VALVG
H
TGSGKSTLASL
L
M
G
YY
P
L
T
EGEIR
L
DG
R
PL
SS
L
S
H
S
A
LR
QG
VAMV
Q
Q
D
P
V
VL
ADT
FLA
N
VT
LG
-
-RDI
SEER
VW
Q
A
LE
T
V
QLA
E
L
A
RS
M
SD
G
I
Y
T
P
LGE
Q
G
N
N
LS
V
GQKQ
LL
A
L
AR
V
L
V
ETPQ
ILILDEAT
AS
ID
SG
TE
Q
AIQHAL
AAVR
E
H
T
T
L
V
VIAHRLSTI
V
DAD
T
I
L
VL
HR
G
Q
A
VE
Q
GTH
QQ
LL
AAQ
G
R
Y
W
QMYQ
L
Q
LA
GEELAASVR
E
EESLSA
fig|679205.4.peg.155
Escherichia coli MS 124-1
MRSFSQLW
P
T
LK
RL
LAYGSP
W
--------
-
R
KPL
G
I
A
V
LMM
WV
A
AAA-
--
E
V
SG
P
LLISYFI
D
N
MVAKNN
L
PLK
M
V
A
G
LA
AA
Y
VGL
QL
FAAG
L
----
---
-
--H
Y
AQ
S
L
L
FNR
A
AVG
VV
QQ
LR
T
D
VMDAAL
RQP
L
S
E
FD
T
Q
P
V
G
Q
V
ISR
V
TND
T
E
VIRDLYV
T
VV
A-------
TV
L
R
SA
ALV
G
A
---
M
L
V
A
MF
SL
D
W
RM
---
A
L
V
A
I
M
I
F
PVV
LV
VMVIYQ
R
YSTP
IV
R
RVR
A
YLA
D
I
ND
----
G
FNE
I
IN
G
MSV
I
QQ
F
R
-----------
QQA
R
FGERMGEASRSHYMAR
MQ
TL
R
L
D
G
F
LL
R
P
L
L
S
L
FS
SL
I
L
CG
LL
M
L
F
G
F
S
---
A
S
G
TIE
V
G
V
L
Y
A
F
I
SYLG
R
L
NE
PL
IE
LT
TQ
-------
Q
A
ML
Q
Q
AV
V
A
GERV
F
E
L
M
DG
P
R
QQ
-----
Y
GNDD
R
PLQ
S
GT
-
-
I
E
VD
NV
S
F
A
Y
-
RD
D
N
LV
LKNINL
S
V
P
S
R
NF
VALVG
H
TGSGKSTLASL
L
M
G
YY
P
L
T
EGEIR
L
DG
R
PL
SS
L
S
H
S
A
LR
QG
VAMV
Q
Q
D
P
V
VL
ADT
FLA
N
VT
LG
-
-RDI
SEER
VW
Q
A
LE
T
V
QLA
E
L
A
RS
M
SD
G
I
Y
T
P
LGE
Q
G
N
N
LS
V
GQKQ
LL
A
L
AR
V
L
V
ETPQ
ILILDEAT
AS
ID
SG
TE
Q
AIQHAL
AAVR
E
H
T
T
L
V
VIAHRLSTI
V
DAD
T
I
L
VL
HR
G
Q
A
VE
Q
GTH
QQ
LL
AAQ
G
R
Y
W
QMYQ
L
Q
LA
GEELAASVR
E
EESLSA
fig|679204.3.peg.1952
Escherichia coli MS 145-7
MRSFSQLW
P
T
LK
RL
LAYGSP
W
--------
-
R
KPL
G
I
A
V
LMM
WV
A
AAA-
--
E
V
SG
P
LLISYFI
D
N
MVAKNN
L
PLK
M
V
A
G
LA
AA
Y
VGL
QL
FAAG
L
----
---
-
--H
Y
AQ
S
L
L
FNR
A
AVG
VV
QQ
LR
T
D
VMDAAL
RQP
L
S
E
FD
T
Q
P
V
G
Q
V
ISR
V
TND
T
E
VIRDLYV
T
VV
A-------
TV
L
R
SA
ALV
G
A
---
M
L
V
A
MF
SL
D
W
RM
---
A
L
V
A
I
M
I
F
PVV
LV
VMVIYQ
R
YSTP
IV
R
RVR
A
YLA
D
I
ND
----
G
FNE
I
IN
G
MSV
I
QQ
F
R
-----------
QQA
R
FGERMGEASRSHYMAR
MQ
TL
R
L
D
G
F
LL
R
P
L
L
S
L
FS
SL
I
L
CG
LL
M
L
F
G
F
S
---
A
S
G
TIE
V
G
V
L
Y
A
F
I
SYLG
R
L
NE
PL
IE
LT
TQ
-------
Q
A
ML
Q
Q
AV
V
A
GERV
F
E
L
M
DG
P
R
QQ
-----
Y
GNDD
R
PLQ
S
GT
-
-
I
E
VD
NV
S
F
A
Y
-
RD
D
N
LV
LKNINL
S
V
P
S
R
NF
VALVG
H
TGSGKSTLASL
L
M
G
YY
P
L
T
EGEIR
L
DG
R
PL
SS
L
S
H
S
A
LR
QG
VAMV
Q
Q
D
P
V
VL
ADT
FLA
N
VT
LG
-
-RDI
SEER
VW
Q
A
LE
T
V
QLA
E
L
A
RS
M
SD
G
I
Y
T
P
LGE
Q
G
N
N
LS
V
GQKQ
LL
A
L
AR
V
L
V
ETPQ
ILILDEAT
AS
ID
SG
TE
Q
AIQHAL
AAVR
E
H
T
T
L
V
VIAHRLSTI
V
DAD
T
I
L
VL
HR
G
Q
A
VE
Q
GTH
QQ
LL
AAQ
G
R
Y
W
QMYQ
L
Q
LA
GEELAASVR
E
EESLSA
fig|749533.3.peg.1349
Escherichia coli MS 84-1
MRSFSQLW
P
T
LK
RL
LAYGSP
W
--------
-
R
KPL
G
I
A
V
LMM
WV
A
AAA-
--
E
V
SG
P
LLISYFI
D
N
MVAKNN
L
PLK
M
V
A
G
LA
AA
Y
VGL
QL
FAAG
L
----
---
-
--H
Y
AQ
S
L
L
FNR
A
AVG
VV
QQ
LR
T
D
VMDAAL
RQP
L
S
E
FD
T
Q
P
V
G
Q
V
ISR
V
TND
T
E
VIRDLYV
T
VV
A-------
TV
L
R
SA
ALV
G
A
---
M
L
V
A
MF
SL
D
W
RM
---
A
L
V
A
I
M
I
F
PVV
LV
VMVIYQ
R
YSTP
IV
R
RVR
A
YLA
D
I
ND
----
G
FNE
I
IN
G
MSV
I
QQ
F
R
-----------
QQA
R
FGERMGEASRSHYMAR
MQ
TL
R
L
D
G
F
LL
R
P
L
L
S
L
FS
SL
I
L
CG
LL
M
L
F
G
F
S
---
A
S
G
TIE
V
G
V
L
Y
A
F
I
SYLG
R
L
NE
PL
IE
LT
TQ
-------
Q
A
ML
Q
Q
AV
V
A
GERV
F
E
L
M
DG
P
R
QQ
-----
Y
GNDD
R
PLQ
S
GT
-
-
I
E
VD
NV
S
F
A
Y
-
RD
D
N
LV
LKNINL
S
V
P
S
R
NF
VALVG
H
TGSGKSTLASL
L
M
G
YY
P
L
T
EGEIR
L
DG
R
PL
SS
L
S
H
S
A
LR
QG
VAMV
Q
Q
D
P
V
VL
ADT
FLA
N
VT
LG
-
-RDI
SEER
VW
Q
A
LE
T
V
QLA
E
L
A
RS
M
SD
G
I
Y
T
P
LGE
Q
G
N
N
LS
V
GQKQ
LL
A
L
AR
V
L
V
ETPQ
ILILDEAT
AS
ID
SG
TE
Q
AIQHAL
AAVR
E
H
T
T
L
V
VIAHRLSTI
V
DAD
T
I
L
VL
HR
G
Q
A
VE
Q
GTH
QQ
LL
AAQ
G
R
Y
W
QMYQ
L
Q
LA
GEELAASVR
E
EESLSA
fig|585395.4.peg.449
Escherichia coli O103:H2 str. 12009
MRSFSQLW
P
T
LK
RL
LAYGSP
W
--------
-
R
KPL
G
I
A
V
LMM
WV
A
AAA-
--
E
V
SG
P
LLISYFI
D
N
MVAKNN
L
PLK
M
V
A
G
LA
AA
Y
VGL
QL
FAAG
L
----
---
-
--H
Y
AQ
S
L
L
FNR
A
AVG
VV
QQ
LR
T
D
VMDAAL
RQP
L
S
E
FD
T
Q
P
V
G
Q
V
ISR
V
TND
T
E
VIRDLYV
T
VV
A-------
TV
L
R
SA
ALV
G
A
---
M
L
V
A
MF
SL
D
W
RM
---
A
L
V
A
I
M
I
F
PVV
LV
VMVIYQ
R
YSTP
IV
R
RVR
A
YLA
D
I
ND
----
G
FNE
I
IN
G
MSV
I
QQ
F
R
-----------
QQA
R
FGERMGEASRSHYMAR
MQ
TL
R
L
D
G
F
LL
R
P
L
L
S
L
FS
SL
I
L
CG
LL
M
L
F
G
F
S
---
A
S
G
TIE
V
G
V
L
Y
A
F
I
SYLG
R
L
NE
PL
IE
LT
TQ
-------
Q
A
ML
Q
Q
AV
V
A
GERV
F
E
L
M
DG
P
R
QQ
-----
Y
GNDD
R
PLQ
S
GT
-
-
I
E
VD
NV
S
F
A
Y
-
RD
D
N
LV
LKNINL
S
V
P
S
R
NF
VALVG
H
TGSGKSTLASL
L
M
G
YY
P
L
T
EGEIR
L
DG
R
PL
SS
L
S
H
S
A
LR
QG
VAMV
Q
Q
D
P
V
VL
ADT
FLA
N
VT
LG
-
-RDI
SEER
VW
Q
A
LE
T
V
QLA
E
L
A
RS
M
SD
G
I
Y
T
P
LGE
Q
G
N
N
LS
V
GQKQ
LL
A
L
AR
V
L
V
ETPQ
ILILDEAT
AS
ID
SG
TE
Q
AIQHAL
AAVR
E
H
T
T
L
V
VIAHRLSTI
V
DAD
T
I
L
VL
HR
G
Q
A
VE
Q
GTH
QQ
LL
AAQ
G
R
Y
W
QMYQ
L
Q
LA
GEELAASVR
E
EESLSA
fig|585396.4.peg.498
Escherichia coli O111:H- str. 11128
MRSFSQLW
P
T
LK
RL
LAYGSP
W
--------
-
R
KPL
G
I
A
V
LMM
WV
A
AAA-
--
E
V
SG
P
LLISYFI
D
N
MVAKNN
L
PLK
M
V
A
G
LA
AA
Y
VGL
QL
FAAG
L
----
---
-
--H
Y
AQ
S
L
L
FNR
A
AVG
VV
QQ
LR
T
D
VMDAAL
RQP
L
S
E
FD
T
Q
P
V
G
Q
V
ISR
V
TND
T
E
VIRDLYV
T
VV
A-------
TV
L
R
SA
ALV
G
A
---
M
L
V
A
MF
SL
D
W
RM
---
A
L
V
A
I
M
I
F
PVV
LV
VMVIYQ
R
YSTP
IV
R
RVR
A
YLA
D
I
ND
----
G
FNE
I
IN
G
MSV
I
QQ
F
R
-----------
QQA
R
FGERMGEASRSHYMAR
MQ
TL
R
L
D
G
F
LL
R
P
L
L
S
L
FS
SL
I
L
CG
LL
M
L
F
G
F
S
---
A
S
G
TIE
V
G
V
L
Y
A
F
I
SYLG
R
L
NE
PL
IE
LT
TQ
-------
Q
A
ML
Q
Q
AV
V
A
GERV
F
E
L
M
DG
P
R
QQ
-----
Y
GNDD
R
PLQ
S
GT
-
-
I
E
VD
NV
S
F
A
Y
-
RD
D
N
LV
LKNINL
S
V
P
S
R
NF
VALVG
H
TGSGKSTLASL
L
M
G
YY
P
L
T
EGEIR
L
DG
R
PL
SS
L
S
H
S
A
LR
QG
VAMV
Q
Q
D
P
V
VL
ADT
FLA
N
VT
LG
-
-RDI
SEER
VW
Q
A
LE
T
V
QLA
E
L
A
RS
M
SD
G
I
Y
T
P
LGE
Q
G
N
N
LS
V
GQKQ
LL
A
L
AR
V
L
V
ETPQ
ILILDEAT
AS
ID
SG
TE
Q
AIQHAL
AAVR
E
H
T
T
L
V
VIAHRLSTI
V
DAD
T
I
L
VL
HR
G
Q
A
VE
Q
GTH
QQ
LL
AAQ
G
R
Y
W
QMYQ
L
Q
LA
GEELAASVR
E
EESLSA
fig|573235.3.peg.490
Escherichia coli O26:H11 str. 11368
MRSFSQLW
P
T
LK
RL
LAYGSP
W
--------
-
R
KPL
G
I
A
V
LMM
WV
A
AAA-
--
E
V
SG
P
LLISYFI
D
N
MVAKNN
L
PLK
M
V
A
G
LA
AA
Y
VGL
QL
FAAG
L
----
---
-
--H
Y
AQ
S
L
L
FNR
A
AVG
VV
QQ
LR
T
D
VMDAAL
RQP
L
S
E
FD
T
Q
P
V
G
Q
V
ISR
V
TND
T
E
VIRDLYV
T
VV
A-------
TV
L
R
SA
ALV
G
A
---
M
L
V
A
MF
SL
D
W
RM
---
A
L
V
A
I
M
I
F
PVV
LV
VMVIYQ
R
YSTP
IV
R
RVR
A
YLA
D
I
ND
----
G
FNE
I
IN
G
MSV
I
QQ
F
R
-----------
QQA
R
FGERMGEASRSHYMAR
MQ
TL
R
L
D
G
F
LL
R
P
L
L
S
L
FS
SL
I
L
CG
LL
M
L
F
G
F
S
---
A
S
G
TIE
V
G
V
L
Y
A
F
I
SYLG
R
L
NE
PL
IE
LT
TQ
-------
Q
A
ML
Q
Q
AV
V
A
GERV
F
E
L
M
DG
P
R
QQ
-----
Y
GNDD
R
PLQ
S
GT
-
-
I
E
VD
NV
S
F
A
Y
-
RD
D
N
LV
LKNINL
S
V
P
S
R
NF
VALVG
H
TGSGKSTLASL
L
M
G
YY
P
L
T
EGEIR
L
DG
R
PL
SS
L
S
H
S
A
LR
QG
VAMV
Q
Q
D
P
V
VL
ADT
FLA
N
VT
LG
-
-RDI
SEER
VW
Q
A
LE
T
V
QLA
E
L
A
RS
M
SD
G
I
Y
T
P
LGE
Q
G
N
N
LS
V
GQKQ
LL
A
L
AR
V
L
V
ETPQ
ILILDEAT
AS
ID
SG
TE
Q
AIQHAL
AAVR
E
H
T
T
L
V
VIAHRLSTI
V
DAD
T
I
L
VL
HR
G
Q
A
VE
Q
GTH
QQ
LL
AAQ
G
R
Y
W
QMYQ
L
Q
LA
GEELAASVR
E
EESLSA
fig|562.371.peg.2703
Escherichia coli 1044A
MRSFSQLW
P
T
LK
RL
LAYGSP
W
--------
-
R
KPL
G
I
A
V
LMM
WV
A
AAA-
--
E
V
SG
P
LLISYFI
D
N
MVAKNN
L
PLK
V
V
A
G
LA
AA
Y
VGL
QL
FAAG
L
----
---
-
--H
Y
AQ
S
L
L
FNR
A
AVG
VV
QQ
LR
T
D
VMDAAL
RQP
L
S
E
FD
T
Q
P
V
G
Q
V
ISR
V
TND
T
E
VIRDLYV
T
VV
A-------
TV
L
R
SA
ALV
G
A
---
M
L
V
A
MF
SL
D
W
RM
---
A
L
V
A
I
M
I
F
PVV
LV
VMVIYQ
R
YSTP
IV
R
RVR
A
YLA
D
I
ND
----
G
FNE
I
IN
G
MSV
I
QQ
F
R
-----------
QQA
R
FGERMGEASRSHYMAR
MQ
TL
R
L
D
G
F
LL
R
P
L
L
S
L
FS
SL
I
L
CG
LL
M
L
F
G
F
S
---
A
S
G
TIE
V
G
V
L
Y
A
F
I
SYLG
R
L
NE
PL
IE
LT
TQ
-------
Q
A
ML
Q
Q
AV
V
A
GERV
F
E
L
M
DG
P
R
QQ
-----
Y
GNDD
R
PLQ
S
GT
-
-
I
E
VD
NV
S
F
A
Y
-
RD
D
N
LV
LKNINL
S
V
P
S
R
NF
VALVG
H
TGSGKSTLASL
L
M
G
YY
P
L
T
EGEIR
L
DG
R
PL
SS
L
S
H
S
A
LR
QG
VAMV
Q
Q
D
P
V
VL
ADT
FLA
N
VT
LG
-
-RDI
SEER
VW
Q
A
LE
T
V
QLA
E
L
A
RS
M
SD
G
I
Y
T
P
LGE
Q
G
N
N
LS
V
GQKQ
LL
A
L
AR
V
L
V
ETPQ
ILILDEAT
AS
ID
SG
TE
Q
AIQHAL
AAVR
E
H
T
T
L
V
VIAHRLSTI
V
DAD
T
I
L
VL
HR
G
Q
A
VE
Q
GTH
QQ
LL
AAQ
G
R
Y
W
QMYQ
L
Q
LA
GEELAASVR
E
EESLSA
fig|562.373.peg.3293
Escherichia coli 1125A
MRSFSQLW
P
T
LK
RL
LAYGSP
W
--------
-
R
KPL
G
I
A
V
LMM
WV
A
AAA-
--
E
V
SG
P
LLISYFI
D
N
MVAKNN
L
PLK
V
V
A
G
LA
AA
Y
VGL
QL
FAAG
L
----
---
-
--H
Y
AQ
S
L
L
FNR
A
AVG
VV
QQ
LR
T
D
VMDAAL
RQP
L
S
E
FD
T
Q
P
V
G
Q
V
ISR
V
TND
T
E
VIRDLYV
T
VV
A-------
TV
L
R
SA
ALV
G
A
---
M
L
V
A
MF
SL
D
W
RM
---
A
L
V
A
I
M
I
F
PVV
LV
VMVIYQ
R
YSTP
IV
R
RVR
A
YLA
D
I
ND
----
G
FNE
I
IN
G
MSV
I
QQ
F
R
-----------
QQA
R
FGERMGEASRSHYMAR
MQ
TL
R
L
D
G
F
LL
R
P
L
L
S
L
FS
SL
I
L
CG
LL
M
L
F
G
F
S
---
A
S
G
TIE
V
G
V
L
Y
A
F
I
SYLG
R
L
NE
PL
IE
LT
TQ
-------
Q
A
ML
Q
Q
AV
V
A
GERV
F
E
L
M
DG
P
R
QQ
-----
Y
GNDD
R
PLQ
S
GT
-
-
I
E
VD
NV
S
F
A
Y
-
RD
D
N
LV
LKNINL
S
V
P
S
R
NF
VALVG
H
TGSGKSTLASL
L
M
G
YY
P
L
T
EGEIR
L
DG
R
PL
SS
L
S
H
S
A
LR
QG
VAMV
Q
Q
D
P
V
VL
ADT
FLA
N
VT
LG
-
-RDI
SEER
VW
Q
A
LE
T
V
QLA
E
L
A
RS
M
SD
G
I
Y
T
P
LGE
Q
G
N
N
LS
V
GQKQ
LL
A
L
AR
V
L
V
ETPQ
ILILDEAT
AS
ID
SG
TE
Q
AIQHAL
AAVR
E
H
T
T
L
V
VIAHRLSTI
V
DAD
T
I
L
VL
HR
G
Q
A
VE
Q
GTH
QQ
LL
AAQ
G
R
Y
W
QMYQ
L
Q
LA
GEELAASVR
E
EESLSA
fig|562.372.peg.1434
Escherichia coli 1212A
MRSFSQLW
P
T
LK
RL
LAYGSP
W
--------
-
R
KPL
G
I
A
V
LMM
WV
A
AAA-
--
E
V
SG
P
LLISYFI
D
N
MVAKNN
L
PLK
V
V
A
G
LA
AA
Y
VGL
QL
FAAG
L
----
---
-
--H
Y
AQ
S
L
L
FNR
A
AVG
VV
QQ
LR
T
D
VMDAAL
RQP
L
S
E
FD
T
Q
P
V
G
Q
V
ISR
V
TND
T
E
VIRDLYV
T
VV
A-------
TV
L
R
SA
ALV
G
A
---
M
L
V
A
MF
SL
D
W
RM
---
A
L
V
A
I
M
I
F
PVV
LV
VMVIYQ
R
YSTP
IV
R
RVR
A
YLA
D
I
ND
----
G
FNE
I
IN
G
MSV
I
QQ
F
R
-----------
QQA
R
FGERMGEASRSHYMAR
MQ
TL
R
L
D
G
F
LL
R
P
L
L
S
L
FS
SL
I
L
CG
LL
M
L
F
G
F
S
---
A
S
G
TIE
V
G
V
L
Y
A
F
I
SYLG
R
L
NE
PL
IE
LT
TQ
-------
Q
A
ML
Q
Q
AV
V
A
GERV
F
E
L
M
DG
P
R
QQ
-----
Y
GNDD
R
PLQ
S
GT
-
-
I
E
VD
NV
S
F
A
Y
-
RD
D
N
LV
LKNINL
S
V
P
S
R
NF
VALVG
H
TGSGKSTLASL
L
M
G
YY
P
L
T
EGEIR
L
DG
R
PL
SS
L
S
H
S
A
LR
QG
VAMV
Q
Q
D
P
V
VL
ADT
FLA
N
VT
LG
-
-RDI
SEER
VW
Q
A
LE
T
V
QLA
E
L
A
RS
M
SD
G
I
Y
T
P
LGE
Q
G
N
N
LS
V
GQKQ
LL
A
L
AR
V
L
V
ETPQ
ILILDEAT
AS
ID
SG
TE
Q
AIQHAL
AAVR
E
H
T
T
L
V
VIAHRLSTI
V
DAD
T
I
L
VL
HR
G
Q
A
VE
Q
GTH
QQ
LL
AAQ
G
R
Y
W
QMYQ
L
Q
LA
GEELAASVR
E
EESLSA
fig|670888.3.peg.1032
Escherichia coli 1827-70
MRSFSQLW
P
T
LK
RL
LAYGSP
W
--------
-
R
KPL
G
I
A
V
LMM
WV
A
AAA-
--
E
V
SG
P
LLISYFI
D
N
MVAKNN
L
PLK
V
V
A
G
LA
AA
Y
VGL
QL
FAAG
L
----
---
-
--H
Y
AQ
S
L
L
FNR
A
AVG
VV
QQ
LR
T
D
VMDAAL
RQP
L
S
E
FD
T
Q
P
V
G
Q
V
ISR
V
TND
T
E
VIRDLYV
T
VV
A-------
TV
L
R
SA
ALV
G
A
---
M
L
V
A
MF
SL
D
W
RM
---
A
L
V
A
I
M
I
F
PVV
LV
VMVIYQ
R
YSTP
IV
R
RVR
A
YLA
D
I
ND
----
G
FNE
I
IN
G
MSV
I
QQ
F
R
-----------
QQA
R
FGERMGEASRSHYMAR
MQ
TL
R
L
D
G
F
LL
R
P
L
L
S
L
FS
SL
I
L
CG
LL
M
L
F
G
F
S
---
A
S
G
TIE
V
G
V
L
Y
A
F
I
SYLG
R
L
NE
PL
IE
LT
TQ
-------
Q
A
ML
Q
Q
AV
V
A
GERV
F
E
L
M
DG
P
R
QQ
-----
Y
GNDD
R
PLQ
S
GT
-
-
I
E
VD
NV
S
F
A
Y
-
RD
D
N
LV
LKNINL
S
V
P
S
R
NF
VALVG
H
TGSGKSTLASL
L
M
G
YY
P
L
T
EGEIR
L
DG
R
PL
SS
L
S
H
S
A
LR
QG
VAMV
Q
Q
D
P
V
VL
ADT
FLA
N
VT
LG
-
-RDI
SEER
VW
Q
A
LE
T
V
QLA
E
L
A
RS
M
SD
G
I
Y
T
P
LGE
Q
G
N
N
LS
V
GQKQ
LL
A
L
AR
V
L
V
ETPQ
ILILDEAT
AS
ID
SG
TE
Q
AIQHAL
AAVR
E
H
T
T
L
V
VIAHRLSTI
V
DAD
T
I
L
VL
HR
G
Q
A
VE
Q
GTH
QQ
LL
AAQ
G
R
Y
W
QMYQ
L
Q
LA
GEELAASVR
E
EESLSA
fig|344610.3.peg.1458
Escherichia coli 53638
MRSFSQLW
P
T
LK
RL
LAYGSP
W
--------
-
R
KPL
G
I
A
V
LMM
WV
A
AAA-
--
E
V
SG
P
LLISYFI
D
N
MVAKNN
L
PLK
V
V
A
G
LA
AA
Y
VGL
QL
FAAG
L
----
---
-
--H
Y
AQ
S
L
L
FNR
A
AVG
VV
QQ
LR
T
D
VMDAAL
RQP
L
S
E
FD
T
Q
P
V
G
Q
V
ISR
V
TND
T
E
VIRDLYV
T
VV
A-------
TV
L
R
SA
ALV
G
A
---
M
L
V
A
MF
SL
D
W
RM
---
A
L
V
A
I
M
I
F
PVV
LV
VMVIYQ
R
YSTP
IV
R
RVR
A
YLA
D
I
ND
----
G
FNE
I
IN
G
MSV
I
QQ
F
R
-----------
QQA
R
FGERMGEASRSHYMAR
MQ
TL
R
L
D
G
F
LL
R
P
L
L
S
L
FS
SL
I
L
CG
LL
M
L
F
G
F
S
---
A
S
G
TIE
V
G
V
L
Y
A
F
I
SYLG
R
L
NE
PL
IE
LT
TQ
-------
Q
A
ML
Q
Q
AV
V
A
GERV
F
E
L
M
DG
P
R
QQ
-----
Y
GNDD
R
PLQ
S
GT
-
-
I
E
VD
NV
S
F
A
Y
-
RD
D
N
LV
LKNINL
S
V
P
S
R
NF
VALVG
H
TGSGKSTLASL
L
M
G
YY
P
L
T
EGEIR
L
DG
R
PL
SS
L
S
H
S
A
LR
QG
VAMV
Q
Q
D
P
V
VL
ADT
FLA
N
VT
LG
-
-RDI
SEER
VW
Q
A
LE
T
V
QLA
E
L
A
RS
M
SD
G
I
Y
T
P
LGE
Q
G
N
N
LS
V
GQKQ
LL
A
L
AR
V
L
V
ETPQ
ILILDEAT
AS
ID
SG
TE
Q
AIQHAL
AAVR
E
H
T
T
L
V
VIAHRLSTI
V
DAD
T
I
L
VL
HR
G
Q
A
VE
Q
GTH
QQ
LL
AAQ
G
R
Y
W
QMYQ
L
Q
LA
GEELAASVR
E
EESLSA
fig|344610.7.peg.1224
Escherichia coli 53638
MRSFSQLW
P
T
LK
RL
LAYGSP
W
--------
-
R
KPL
G
I
A
V
LMM
WV
A
AAA-
--
E
V
SG
P
LLISYFI
D
N
MVAKNN
L
PLK
V
V
A
G
LA
AA
Y
VGL
QL
FAAG
L
----
---
-
--H
Y
AQ
S
L
L
FNR
A
AVG
VV
QQ
LR
T
D
VMDAAL
RQP
L
S
E
FD
T
Q
P
V
G
Q
V
ISR
V
TND
T
E
VIRDLYV
T
VV
A-------
TV
L
R
SA
ALV
G
A
---
M
L
V
A
MF
SL
D
W
RM
---
A
L
V
A
I
M
I
F
PVV
LV
VMVIYQ
R
YSTP
IV
R
RVR
A
YLA
D
I
ND
----
G
FNE
I
IN
G
MSV
I
QQ
F
R
-----------
QQA
R
FGERMGEASRSHYMAR
MQ
TL
R
L
D
G
F
LL
R
P
L
L
S
L
FS
SL
I
L
CG
LL
M
L
F
G
F
S
---
A
S
G
TIE
V
G
V
L
Y
A
F
I
SYLG
R
L
NE
PL
IE
LT
TQ
-------
Q
A
ML
Q
Q
AV
V
A
GERV
F
E
L
M
DG
P
R
QQ
-----
Y
GNDD
R
PLQ
S
GT
-
-
I
E
VD
NV
S
F
A
Y
-
RD
D
N
LV
LKNINL
S
V
P
S
R
NF
VALVG
H
TGSGKSTLASL
L
M
G
YY
P
L
T
EGEIR
L
DG
R
PL
SS
L
S
H
S
A
LR
QG
VAMV
Q
Q
D
P
V
VL
ADT
FLA
N
VT
LG
-
-RDI
SEER
VW
Q
A
LE
T
V
QLA
E
L
A
RS
M
SD
G
I
Y
T
P
LGE
Q
G
N
N
LS
V
GQKQ
LL
A
L
AR
V
L
V
ETPQ
ILILDEAT
AS
ID
SG
TE
Q
AIQHAL
AAVR
E
H
T
T
L
V
VIAHRLSTI
V
DAD
T
I
L
VL
HR
G
Q
A
VE
Q
GTH
QQ
LL
AAQ
G
R
Y
W
QMYQ
L
Q
LA
GEELAASVR
E
EESLSA
fig|562.374.peg.5542
Escherichia coli 536A
MRSFSQLW
P
T
LK
RL
LAYGSP
W
--------
-
R
KPL
G
I
A
V
LMM
WV
A
AAA-
--
E
V
SG
P
LLISYFI
D
N
MVAKNN
L
PLK
V
V
A
G
LA
AA
Y
VGL
QL
FAAG
L
----
---
-
--H
Y
AQ
S
L
L
FNR
A
AVG
VV
QQ
LR
T
D
VMDAAL
RQP
L
S
E
FD
T
Q
P
V
G
Q
V
ISR
V
TND
T
E
VIRDLYV
T
VV
A-------
TV
L
R
SA
ALV
G
A
---
M
L
V
A
MF
SL
D
W
RM
---
A
L
V
A
I
M
I
F
PVV
LV
VMVIYQ
R
YSTP
IV
R
RVR
A
YLA
D
I
ND
----
G
FNE
I
IN
G
MSV
I
QQ
F
R
-----------
QQA
R
FGERMGEASRSHYMAR
MQ
TL
R
L
D
G
F
LL
R
P
L
L
S
L
FS
SL
I
L
CG
LL
M
L
F
G
F
S
---
A
S
G
TIE
V
G
V
L
Y
A
F
I
SYLG
R
L
NE
PL
IE
LT
TQ
-------
Q
A
ML
Q
Q
AV
V
A
GERV
F
E
L
M
DG
P
R
QQ
-----
Y
GNDD
R
PLQ
S
GT
-
-
I
E
VD
NV
S
F
A
Y
-
RD
D
N
LV
LKNINL
S
V
P
S
R
NF
VALVG
H
TGSGKSTLASL
L
M
G
YY
P
L
T
EGEIR
L
DG
R
PL
SS
L
S
H
S
A
LR
QG
VAMV
Q
Q
D
P
V
VL
ADT
FLA
N
VT
LG
-
-RDI
SEER
VW
Q
A
LE
T
V
QLA
E
L
A
RS
M
SD
G
I
Y
T
P
LGE
Q
G
N
N
LS
V
GQKQ
LL
A
L
AR
V
L
V
ETPQ
ILILDEAT
AS
ID
SG
TE
Q
AIQHAL
AAVR
E
H
T
T
L
V
VIAHRLSTI
V
DAD
T
I
L
VL
HR
G
Q
A
VE
Q
GTH
QQ
LL
AAQ
G
R
Y
W
QMYQ
L
Q
LA
GEELAASVR
E
EESLSA
fig|525281.3.peg.2456
Escherichia coli 83972
MRSFSQLW
P
T
LK
RL
LAYGSP
W
--------
-
R
KPL
G
I
A
V
LMM
WV
A
AAA-
--
E
V
SG
P
LLISYFI
D
N
MVAKNN
L
PLK
V
V
A
G
LA
AA
Y
VGL
QL
FAAG
L
----
---
-
--H
Y
AQ
S
L
L
FNR
A
AVG
VV
QQ
LR
T
D
VMDAAL
RQP
L
S
E
FD
T
Q
P
V
G
Q
V
ISR
V
TND
T
E
VIRDLYV
T
VV
A-------
TV
L
R
SA
ALV
G
A
---
M
L
V
A
MF
SL
D
W
RM
---
A
L
V
A
I
M
I
F
PVV
LV
VMVIYQ
R
YSTP
IV
R
RVR
A
YLA
D
I
ND
----
G
FNE
I
IN
G
MSV
I
QQ
F
R
-----------
QQA
R
FGERMGEASRSHYMAR
MQ
TL
R
L
D
G
F
LL
R
P
L
L
S
L
FS
SL
I
L
CG
LL
M
L
F
G
F
S
---
A
S
G
TIE
V
G
V
L
Y
A
F
I
SYLG
R
L
NE
PL
IE
LT
TQ
-------
Q
A
ML
Q
Q
AV
V
A
GERV
F
E
L
M
DG
P
R
QQ
-----
Y
GNDD
R
PLQ
S
GT
-
-
I
E
VD
NV
S
F
A
Y
-
RD
D
N
LV
LKNINL
S
V
P
S
R
NF
VALVG
H
TGSGKSTLASL
L
M
G
YY
P
L
T
EGEIR
L
DG
R
PL
SS
L
S
H
S
A
LR
QG
VAMV
Q
Q
D
P
V
VL
ADT
FLA
N
VT
LG
-
-RDI
SEER
VW
Q
A
LE
T
V
QLA
E
L
A
RS
M
SD
G
I
Y
T
P
LGE
Q
G
N
N
LS
V
GQKQ
LL
A
L
AR
V
L
V
ETPQ
ILILDEAT
AS
ID
SG
TE
Q
AIQHAL
AAVR
E
H
T
T
L
V
VIAHRLSTI
V
DAD
T
I
L
VL
HR
G
Q
A
VE
Q
GTH
QQ
LL
AAQ
G
R
Y
W
QMYQ
L
Q
LA
GEELAASVR
E
EESLSA
fig|655817.3.peg.567
Escherichia coli ABU 83972
MRSFSQLW
P
T
LK
RL
LAYGSP
W
--------
-
R
KPL
G
I
A
V
LMM
WV
A
AAA-
--
E
V
SG
P
LLISYFI
D
N
MVAKNN
L
PLK
V
V
A
G
LA
AA
Y
VGL
QL
FAAG
L
----
---
-
--H
Y
AQ
S
L
L
FNR
A
AVG
VV
QQ
LR
T
D
VMDAAL
RQP
L
S
E
FD
T
Q
P
V
G
Q
V
ISR
V
TND
T
E
VIRDLYV
T
VV
A-------
TV
L
R
SA
ALV
G
A
---
M
L
V
A
MF
SL
D
W
RM
---
A
L
V
A
I
M
I
F
PVV
LV
VMVIYQ
R
YSTP
IV
R
RVR
A
YLA
D
I
ND
----
G
FNE
I
IN
G
MSV
I
QQ
F
R
-----------
QQA
R
FGERMGEASRSHYMAR
MQ
TL
R
L
D
G
F
LL
R
P
L
L
S
L
FS
SL
I
L
CG
LL
M
L
F
G
F
S
---
A
S
G
TIE
V
G
V
L
Y
A
F
I
SYLG
R
L
NE
PL
IE
LT
TQ
-------
Q
A
ML
Q
Q
AV
V
A
GERV
F
E
L
M
DG
P
R
QQ
-----
Y
GNDD
R
PLQ
S
GT
-
-
I
E
VD
NV
S
F
A
Y
-
RD
D
N
LV
LKNINL
S
V
P
S
R
NF
VALVG
H
TGSGKSTLASL
L
M
G
YY
P
L
T
EGEIR
L
DG
R
PL
SS
L
S
H
S
A
LR
QG
VAMV
Q
Q
D
P
V
VL
ADT
FLA
N
VT
LG
-
-RDI
SEER
VW
Q
A
LE
T
V
QLA
E
L
A
RS
M
SD
G
I
Y
T
P
LGE
Q
G
N
N
LS
V
GQKQ
LL
A
L
AR
V
L
V
ETPQ
ILILDEAT
AS
ID
SG
TE
Q
AIQHAL
AAVR
E
H
T
T
L
V
VIAHRLSTI
V
DAD
T
I
L
VL
HR
G
Q
A
VE
Q
GTH
QQ
LL
AAQ
G
R
Y
W
QMYQ
L
Q
LA
GEELAASVR
E
EESLSA
fig|481805.3.peg.3390
Escherichia coli ATCC 8739
MRSFSQLW
P
T
LK
RL
LAYGSP
W
--------
-
R
KPL
G
I
A
V
LMM
WV
A
AAA-
--
E
V
SG
P
LLISYFI
D
N
MVAKNN
L
PLK
V
V
A
G
LA
AA
Y
VGL
QL
FAAG
L
----
---
-
--H
Y
AQ
S
L
L
FNR
A
AVG
VV
QQ
LR
T
D
VMDAAL
RQP
L
S
E
FD
T
Q
P
V
G
Q
V
ISR
V
TND
T
E
VIRDLYV
T
VV
A-------
TV
L
R
SA
ALV
G
A
---
M
L
V
A
MF
SL
D
W
RM
---
A
L
V
A
I
M
I
F
PVV
LV
VMVIYQ
R
YSTP
IV
R
RVR
A
YLA
D
I
ND
----
G
FNE
I
IN
G
MSV
I
QQ
F
R
-----------
QQA
R
FGERMGEASRSHYMAR
MQ
TL
R
L
D
G
F
LL
R
P
L
L
S
L
FS
SL
I
L
CG
LL
M
L
F
G
F
S
---
A
S
G
TIE
V
G
V
L
Y
A
F
I
SYLG
R
L
NE
PL
IE
LT
TQ
-------
Q
A
ML
Q
Q
AV
V
A
GERV
F
E
L
M
DG
P
R
QQ
-----
Y
GNDD
R
PLQ
S
GT
-
-
I
E
VD
NV
S
F
A
Y
-
RD
D
N
LV
LKNINL
S
V
P
S
R
NF
VALVG
H
TGSGKSTLASL
L
M
G
YY
P
L
T
EGEIR
L
DG
R
PL
SS
L
S
H
S
A
LR
QG
VAMV
Q
Q
D
P
V
VL
ADT
FLA
N
VT
LG
-
-RDI
SEER
VW
Q
A
LE
T
V
QLA
E
L
A
RS
M
SD
G
I
Y
T
P
LGE
Q
G
N
N
LS
V
GQKQ
LL
A
L
AR
V
L
V
ETPQ
ILILDEAT
AS
ID
SG
TE
Q
AIQHAL
AAVR
E
H
T
T
L
V
VIAHRLSTI
V
DAD
T
I
L
VL
HR
G
Q
A
VE
Q
GTH
QQ
LL
AAQ
G
R
Y
W
QMYQ
L
Q
LA
GEELAASVR
E
EESLSA
fig|481805.6.peg.3379
Escherichia coli ATCC 8739
MRSFSQLW
P
T
LK
RL
LAYGSP
W
--------
-
R
KPL
G
I
A
V
LMM
WV
A
AAA-
--
E
V
SG
P
LLISYFI
D
N
MVAKNN
L
PLK
V
V
A
G
LA
AA
Y
VGL
QL
FAAG
L
----
---
-
--H
Y
AQ
S
L
L
FNR
A
AVG
VV
QQ
LR
T
D
VMDAAL
RQP
L
S
E
FD
T
Q
P
V
G
Q
V
ISR
V
TND
T
E
VIRDLYV
T
VV
A-------
TV
L
R
SA
ALV
G
A
---
M
L
V
A
MF
SL
D
W
RM
---
A
L
V
A
I
M
I
F
PVV
LV
VMVIYQ
R
YSTP
IV
R
RVR
A
YLA
D
I
ND
----
G
FNE
I
IN
G
MSV
I
QQ
F
R
-----------
QQA
R
FGERMGEASRSHYMAR
MQ
TL
R
L
D
G
F
LL
R
P
L
L
S
L
FS
SL
I
L
CG
LL
M
L
F
G
F
S
---
A
S
G
TIE
V
G
V
L
Y
A
F
I
SYLG
R
L
NE
PL
IE
LT
TQ
-------
Q
A
ML
Q
Q
AV
V
A
GERV
F
E
L
M
DG
P
R
QQ
-----
Y
GNDD
R
PLQ
S
GT
-
-
I
E
VD
NV
S
F
A
Y
-
RD
D
N
LV
LKNINL
S
V
P
S
R
NF
VALVG
H
TGSGKSTLASL
L
M
G
YY
P
L
T
EGEIR
L
DG
R
PL
SS
L
S
H
S
A
LR
QG
VAMV
Q
Q
D
P
V
VL
ADT
FLA
N
VT
LG
-
-RDI
SEER
VW
Q
A
LE
T
V
QLA
E
L
A
RS
M
SD
G
I
Y
T
P
LGE
Q
G
N
N
LS
V
GQKQ
LL
A
L
AR
V
L
V
ETPQ
ILILDEAT
AS
ID
SG
TE
Q
AIQHAL
AAVR
E
H
T
T
L
V
VIAHRLSTI
V
DAD
T
I
L
VL
HR
G
Q
A
VE
Q
GTH
QQ
LL
AAQ
G
R
Y
W
QMYQ
L
Q
LA
GEELAASVR
E
EESLSA
fig|595496.3.peg.370
Escherichia coli BW2952
MRSFSQLW
P
T
LK
RL
LAYGSP
W
--------
-
R
KPL
G
I
A
V
LMM
WV
A
AAA-
--
E
V
SG
P
LLISYFI
D
N
MVAKNN
L
PLK
V
V
A
G
LA
AA
Y
VGL
QL
FAAG
L
----
---
-
--H
Y
AQ
S
L
L
FNR
A
AVG
VV
QQ
LR
T
D
VMDAAL
RQP
L
S
E
FD
T
Q
P
V
G
Q
V
ISR
V
TND
T
E
VIRDLYV
T
VV
A-------
TV
L
R
SA
ALV
G
A
---
M
L
V
A
MF
SL
D
W
RM
---
A
L
V
A
I
M
I
F
PVV
LV
VMVIYQ
R
YSTP
IV
R
RVR
A
YLA
D
I
ND
----
G
FNE
I
IN
G
MSV
I
QQ
F
R
-----------
QQA
R
FGERMGEASRSHYMAR
MQ
TL
R
L
D
G
F
LL
R
P
L
L
S
L
FS
SL
I
L
CG
LL
M
L
F
G
F
S
---
A
S
G
TIE
V
G
V
L
Y
A
F
I
SYLG
R
L
NE
PL
IE
LT
TQ
-------
Q
A
ML
Q
Q
AV
V
A
GERV
F
E
L
M
DG
P
R
QQ
-----
Y
GNDD
R
PLQ
S
GT
-
-
I
E
VD
NV
S
F
A
Y
-
RD
D
N
LV
LKNINL
S
V
P
S
R
NF
VALVG
H
TGSGKSTLASL
L
M
G
YY
P
L
T
EGEIR
L
DG
R
PL
SS
L
S
H
S
A
LR
QG
VAMV
Q
Q
D
P
V
VL
ADT
FLA
N
VT
LG
-
-RDI
SEER
VW
Q
A
LE
T
V
QLA
E
L
A
RS
M
SD
G
I
Y
T
P
LGE
Q
G
N
N
LS
V
GQKQ
LL
A
L
AR
V
L
V
ETPQ
ILILDEAT
AS
ID
SG
TE
Q
AIQHAL
AAVR
E
H
T
T
L
V
VIAHRLSTI
V
DAD
T
I
L
VL
HR
G
Q
A
VE
Q
GTH
QQ
LL
AAQ
G
R
Y
W
QMYQ
L
Q
LA
GEELAASVR
E
EESLSA
fig|199310.4.peg.531
Escherichia coli CFT073
MRSFSQLW
P
T
LK
RL
LAYGSP
W
--------
-
R
KPL
G
I
A
V
LMM
WV
A
AAA-
--
E
V
SG
P
LLISYFI
D
N
MVAKNN
L
PLK
V
V
A
G
LA
AA
Y
VGL
QL
FAAG
L
----
---
-
--H
Y
AQ
S
L
L
FNR
A
AVG
VV
QQ
LR
T
D
VMDAAL
RQP
L
S
E
FD
T
Q
P
V
G
Q
V
ISR
V
TND
T
E
VIRDLYV
T
VV
A-------
TV
L
R
SA
ALV
G
A
---
M
L
V
A
MF
SL
D
W
RM
---
A
L
V
A
I
M
I
F
PVV
LV
VMVIYQ
R
YSTP
IV
R
RVR
A
YLA
D
I
ND
----
G
FNE
I
IN
G
MSV
I
QQ
F
R
-----------
QQA
R
FGERMGEASRSHYMAR
MQ
TL
R
L
D
G
F
LL
R
P
L
L
S
L
FS
SL
I
L
CG
LL
M
L
F
G
F
S
---
A
S
G
TIE
V
G
V
L
Y
A
F
I
SYLG
R
L
NE
PL
IE
LT
TQ
-------
Q
A
ML
Q
Q
AV
V
A
GERV
F
E
L
M
DG
P
R
QQ
-----
Y
GNDD
R
PLQ
S
GT
-
-
I
E
VD
NV
S
F
A
Y
-
RD
D
N
LV
LKNINL
S
V
P
S
R
NF
VALVG
H
TGSGKSTLASL
L
M
G
YY
P
L
T
EGEIR
L
DG
R
PL
SS
L
S
H
S
A
LR
QG
VAMV
Q
Q
D
P
V
VL
ADT
FLA
N
VT
LG
-
-RDI
SEER
VW
Q
A
LE
T
V
QLA
E
L
A
RS
M
SD
G
I
Y
T
P
LGE
Q
G
N
N
LS
V
GQKQ
LL
A
L
AR
V
L
V
ETPQ
ILILDEAT
AS
ID
SG
TE
Q
AIQHAL
AAVR
E
H
T
T
L
V
VIAHRLSTI
V
DAD
T
I
L
VL
HR
G
Q
A
VE
Q
GTH
QQ
LL
AAQ
G
R
Y
W
QMYQ
L
Q
LA
GEELAASVR
E
EESLSA
fig|536056.3.peg.3340
Escherichia coli DH1
MRSFSQLW
P
T
LK
RL
LAYGSP
W
--------
-
R
KPL
G
I
A
V
LMM
WV
A
AAA-
--
E
V
SG
P
LLISYFI
D
N
MVAKNN
L
PLK
V
V
A
G
LA
AA
Y
VGL
QL
FAAG
L
----
---
-
--H
Y
AQ
S
L
L
FNR
A
AVG
VV
QQ
LR
T
D
VMDAAL
RQP
L
S
E
FD
T
Q
P
V
G
Q
V
ISR
V
TND
T
E
VIRDLYV
T
VV
A-------
TV
L
R
SA
ALV
G
A
---
M
L
V
A
MF
SL
D
W
RM
---
A
L
V
A
I
M
I
F
PVV
LV
VMVIYQ
R
YSTP
IV
R
RVR
A
YLA
D
I
ND
----
G
FNE
I
IN
G
MSV
I
QQ
F
R
-----------
QQA
R
FGERMGEASRSHYMAR
MQ
TL
R
L
D
G
F
LL
R
P
L
L
S
L
FS
SL
I
L
CG
LL
M
L
F
G
F
S
---
A
S
G
TIE
V
G
V
L
Y
A
F
I
SYLG
R
L
NE
PL
IE
LT
TQ
-------
Q
A
ML
Q
Q
AV
V
A
GERV
F
E
L
M
DG
P
R
QQ
-----
Y
GNDD
R
PLQ
S
GT
-
-
I
E
VD
NV
S
F
A
Y
-
RD
D
N
LV
LKNINL
S
V
P
S
R
NF
VALVG
H
TGSGKSTLASL
L
M
G
YY
P
L
T
EGEIR
L
DG
R
PL
SS
L
S
H
S
A
LR
QG
VAMV
Q
Q
D
P
V
VL
ADT
FLA
N
VT
LG
-
-RDI
SEER
VW
Q
A
LE
T
V
QLA
E
L
A
RS
M
SD
G
I
Y
T
P
LGE
Q
G
N
N
LS
V
GQKQ
LL
A
L
AR
V
L
V
ETPQ
ILILDEAT
AS
ID
SG
TE
Q
AIQHAL
AAVR
E
H
T
T
L
V
VIAHRLSTI
V
DAD
T
I
L
VL
HR
G
Q
A
VE
Q
GTH
QQ
LL
AAQ
G
R
Y
W
QMYQ
L
Q
LA
GEELAASVR
E
EESLSA
fig|585397.7.peg.474
Escherichia coli ED1a
MRSFSQLW
P
T
LK
RL
LAYGSP
W
--------
-
R
KPL
G
I
A
V
LMM
WV
A
AAA-
--
E
V
SG
P
LLISYFI
D
N
MVAKNN
L
PLK
V
V
A
G
LA
AA
Y
VGL
QL
FAAG
L
----
---
-
--H
Y
AQ
S
L
L
FNR
A
AVG
VV
QQ
LR
T
D
VMDAAL
RQP
L
S
E
FD
T
Q
P
V
G
Q
V
ISR
V
TND
T
E
VIRDLYV
T
VV
A-------
TV
L
R
SA
ALV
G
A
---
M
L
V
A
MF
SL
D
W
RM
---
A
L
V
A
I
M
I
F
PVV
LV
VMVIYQ
R
YSTP
IV
R
RVR
A
YLA
D
I
ND
----
G
FNE
I
IN
G
MSV
I
QQ
F
R
-----------
QQA
R
FGERMGEASRSHYMAR
MQ
TL
R
L
D
G
F
LL
R
P
L
L
S
L
FS
SL
I
L
CG
LL
M
L
F
G
F
S
---
A
S
G
TIE
V
G
V
L
Y
A
F
I
SYLG
R
L
NE
PL
IE
LT
TQ
-------
Q
A
ML
Q
Q
AV
V
A
GERV
F
E
L
M
DG
P
R
QQ
-----
Y
GNDD
R
PLQ
S
GT
-
-
I
E
VD
NV
S
F
A
Y
-
RD
D
N
LV
LKNINL
S
V
P
S
R
NF
VALVG
H
TGSGKSTLASL
L
M
G
YY
P
L
T
EGEIR
L
DG
R
PL
SS
L
S
H
S
A
LR
QG
VAMV
Q
Q
D
P
V
VL
ADT
FLA
N
VT
LG
-
-RDI
SEER
VW
Q
A
LE
T
V
QLA
E
L
A
RS
M
SD
G
I
Y
T
P
LGE
Q
G
N
N
LS
V
GQKQ
LL
A
L
AR
V
L
V
ETPQ
ILILDEAT
AS
ID
SG
TE
Q
AIQHAL
AAVR
E
H
T
T
L
V
VIAHRLSTI
V
DAD
T
I
L
VL
HR
G
Q
A
VE
Q
GTH
QQ
LL
AAQ
G
R
Y
W
QMYQ
L
Q
LA
GEELAASVR
E
EESLSA
fig|585397.9.peg.476
Escherichia coli ED1a
MRSFSQLW
P
T
LK
RL
LAYGSP
W
--------
-
R
KPL
G
I
A
V
LMM
WV
A
AAA-
--
E
V
SG
P
LLISYFI
D
N
MVAKNN
L
PLK
V
V
A
G
LA
AA
Y
VGL
QL
FAAG
L
----
---
-
--H
Y
AQ
S
L
L
FNR
A
AVG
VV
QQ
LR
T
D
VMDAAL
RQP
L
S
E
FD
T
Q
P
V
G
Q
V
ISR
V
TND
T
E
VIRDLYV
T
VV
A-------
TV
L
R
SA
ALV
G
A
---
M
L
V
A
MF
SL
D
W
RM
---
A
L
V
A
I
M
I
F
PVV
LV
VMVIYQ
R
YSTP
IV
R
RVR
A
YLA
D
I
ND
----
G
FNE
I
IN
G
MSV
I
QQ
F
R
-----------
QQA
R
FGERMGEASRSHYMAR
MQ
TL
R
L
D
G
F
LL
R
P
L
L
S
L
FS
SL
I
L
CG
LL
M
L
F
G
F
S
---
A
S
G
TIE
V
G
V
L
Y
A
F
I
SYLG
R
L
NE
PL
IE
LT
TQ
-------
Q
A
ML
Q
Q
AV
V
A
GERV
F
E
L
M
DG
P
R
QQ
-----
Y
GNDD
R
PLQ
S
GT
-
-
I
E
VD
NV
S
F
A
Y
-
RD
D
N
LV
LKNINL
S
V
P
S
R
NF
VALVG
H
TGSGKSTLASL
L
M
G
YY
P
L
T
EGEIR
L
DG
R
PL
SS
L
S
H
S
A
LR
QG
VAMV
Q
Q
D
P
V
VL
ADT
FLA
N
VT
LG
-
-RDI
SEER
VW
Q
A
LE
T
V
QLA
E
L
A
RS
M
SD
G
I
Y
T
P
LGE
Q
G
N
N
LS
V
GQKQ
LL
A
L
AR
V
L
V
ETPQ
ILILDEAT
AS
ID
SG
TE
Q
AIQHAL
AAVR
E
H
T
T
L
V
VIAHRLSTI
V
DAD
T
I
L
VL
HR
G
Q
A
VE
Q
GTH
QQ
LL
AAQ
G
R
Y
W
QMYQ
L
Q
LA
GEELAASVR
E
EESLSA
fig|316401.4.peg.577
Escherichia coli ETEC H10407
MRSFSQLW
P
T
LK
RL
LAYGSP
W
--------
-
R
KPL
G
I
A
V
LMM
WV
A
AAA-
--
E
V
SG
P
LLISYFI
D
N
MVAKNN
L
PLK
V
V
A
G
LA
AA
Y
VGL
QL
FAAG
L
----
---
-
--H
Y
AQ
S
L
L
FNR
A
AVG
VV
QQ
LR
T
D
VMDAAL
RQP
L
S
E
FD
T
Q
P
V
G
Q
V
ISR
V
TND
T
E
VIRDLYV
T
VV
A-------
TV
L
R
SA
ALV
G
A
---
M
L
V
A
MF
SL
D
W
RM
---
A
L
V
A
I
M
I
F
PVV
LV
VMVIYQ
R
YSTP
IV
R
RVR
A
YLA
D
I
ND
----
G
FNE
I
IN
G
MSV
I
QQ
F
R
-----------
QQA
R
FGERMGEASRSHYMAR
MQ
TL
R
L
D
G
F
LL
R
P
L
L
S
L
FS
SL
I
L
CG
LL
M
L
F
G
F
S
---
A
S
G
TIE
V
G
V
L
Y
A
F
I
SYLG
R
L
NE
PL
IE
LT
TQ
-------
Q
A
ML
Q
Q
AV
V
A
GERV
F
E
L
M
DG
P
R
QQ
-----
Y
GNDD
R
PLQ
S
GT
-
-
I
E
VD
NV
S
F
A
Y
-
RD
D
N
LV
LKNINL
S
V
P
S
R
NF
VALVG
H
TGSGKSTLASL
L
M
G
YY
P
L
T
EGEIR
L
DG
R
PL
SS
L
S
H
S
A
LR
QG
VAMV
Q
Q
D
P
V
VL
ADT
FLA
N
VT
LG
-
-RDI
SEER
VW
Q
A
LE
T
V
QLA
E
L
A
RS
M
SD
G
I
Y
T
P
LGE
Q
G
N
N
LS
V
GQKQ
LL
A
L
AR
V
L
V
ETPQ
ILILDEAT
AS
ID
SG
TE
Q
AIQHAL
AAVR
E
H
T
T
L
V
VIAHRLSTI
V
DAD
T
I
L
VL
HR
G
Q
A
VE
Q
GTH
QQ
LL
AAQ
G
R
Y
W
QMYQ
L
Q
LA
GEELAASVR
E
EESLSA
fig|656379.3.peg.934
Escherichia coli FVEC1302
MRSFSQLW
P
T
LK
RL
LAYGSP
W
--------
-
R
KPL
G
I
A
V
LMM
WV
A
AAA-
--
E
V
SG
P
LLISYFI
D
N
MVAKNN
L
PLK
V
V
A
G
LA
AA
Y
VGL
QL
FAAG
L
----
---
-
--H
Y
AQ
S
L
L
FNR
A
AVG
VV
QQ
LR
T
D
VMDAAL
RQP
L
S
E
FD
T
Q
P
V
G
Q
V
ISR
V
TND
T
E
VIRDLYV
T
VV
A-------
TV
L
R
SA
ALV
G
A
---
M
L
V
A
MF
SL
D
W
RM
---
A
L
V
A
I
M
I
F
PVV
LV
VMVIYQ
R
YSTP
IV
R
RVR
A
YLA
D
I
ND
----
G
FNE
I
IN
G
MSV
I
QQ
F
R
-----------
QQA
R
FGERMGEASRSHYMAR
MQ
TL
R
L
D
G
F
LL
R
P
L
L
S
L
FS
SL
I
L
CG
LL
M
L
F
G
F
S
---
A
S
G
TIE
V
G
V
L
Y
A
F
I
SYLG
R
L
NE
PL
IE
LT
TQ
-------
Q
A
ML
Q
Q
AV
V
A
GERV
F
E
L
M
DG
P
R
QQ
-----
Y
GNDD
R
PLQ
S
GT
-
-
I
E
VD
NV
S
F
A
Y
-
RD
D
N
LV
LKNINL
S
V
P
S
R
NF
VALVG
H
TGSGKSTLASL
L
M
G
YY
P
L
T
EGEIR
L
DG
R
PL
SS
L
S
H
S
A
LR
QG
VAMV
Q
Q
D
P
V
VL
ADT
FLA
N
VT
LG
-
-RDI
SEER
VW
Q
A
LE
T
V
QLA
E
L
A
RS
M
SD
G
I
Y
T
P
LGE
Q
G
N
N
LS
V
GQKQ
LL
A
L
AR
V
L
V
ETPQ
ILILDEAT
AS
ID
SG
TE
Q
AIQHAL
AAVR
E
H
T
T
L
V
VIAHRLSTI
V
DAD
T
I
L
VL
HR
G
Q
A
VE
Q
GTH
QQ
LL
AAQ
G
R
Y
W
QMYQ
L
Q
LA
GEELAASVR
E
EESLSA
fig|656380.3.peg.1084
Escherichia coli FVEC1412
MRSFSQLW
P
T
LK
RL
LAYGSP
W
--------
-
R
KPL
G
I
A
V
LMM
WV
A
AAA-
--
E
V
SG
P
LLISYFI
D
N
MVAKNN
L
PLK
V
V
A
G
LA
AA
Y
VGL
QL
FAAG
L
----
---
-
--H
Y
AQ
S
L
L
FNR
A
AVG
VV
QQ
LR
T
D
VMDAAL
RQP
L
S
E
FD
T
Q
P
V
G
Q
V
ISR
V
TND
T
E
VIRDLYV
T
VV
A-------
TV
L
R
SA
ALV
G
A
---
M
L
V
A
MF
SL
D
W
RM
---
A
L
V
A
I
M
I
F
PVV
LV
VMVIYQ
R
YSTP
IV
R
RVR
A
YLA
D
I
ND
----
G
FNE
I
IN
G
MSV
I
QQ
F
R
-----------
QQA
R
FGERMGEASRSHYMAR
MQ
TL
R
L
D
G
F
LL
R
P
L
L
S
L
FS
SL
I
L
CG
LL
M
L
F
G
F
S
---
A
S
G
TIE
V
G
V
L
Y
A
F
I
SYLG
R
L
NE
PL
IE
LT
TQ
-------
Q
A
ML
Q
Q
AV
V
A
GERV
F
E
L
M
DG
P
R
QQ
-----
Y
GNDD
R
PLQ
S
GT
-
-
I
E
VD
NV
S
F
A
Y
-
RD
D
N
LV
LKNINL
S
V
P
S
R
NF
VALVG
H
TGSGKSTLASL
L
M
G
YY
P
L
T
EGEIR
L
DG
R
PL
SS
L
S
H
S
A
LR
QG
VAMV
Q
Q
D
P
V
VL
ADT
FLA
N
VT
LG
-
-RDI
SEER
VW
Q
A
LE
T
V
QLA
E
L
A
RS
M
SD
G
I
Y
T
P
LGE
Q
G
N
N
LS
V
GQKQ
LL
A
L
AR
V
L
V
ETPQ
ILILDEAT
AS
ID
SG
TE
Q
AIQHAL
AAVR
E
H
T
T
L
V
VIAHRLSTI
V
DAD
T
I
L
VL
HR
G
Q
A
VE
Q
GTH
QQ
LL
AAQ
G
R
Y
W
QMYQ
L
Q
LA
GEELAASVR
E
EESLSA
fig|331112.3.peg.490
Escherichia coli HS
MRSFSQLW
P
T
LK
RL
LAYGSP
W
--------
-
R
KPL
G
I
A
V
LMM
WV
A
AAA-
--
E
V
SG
P
LLISYFI
D
N
MVAKNN
L
PLK
V
V
A
G
LA
AA
Y
VGL
QL
FAAG
L
----
---
-
--H
Y
AQ
S
L
L
FNR
A
AVG
VV
QQ
LR
T
D
VMDAAL
RQP
L
S
E
FD
T
Q
P
V
G
Q
V
ISR
V
TND
T
E
VIRDLYV
T
VV
A-------
TV
L
R
SA
ALV
G
A
---
M
L
V
A
MF
SL
D
W
RM
---
A
L
V
A
I
M
I
F
PVV
LV
VMVIYQ
R
YSTP
IV
R
RVR
A
YLA
D
I
ND
----
G
FNE
I
IN
G
MSV
I
QQ
F
R
-----------
QQA
R
FGERMGEASRSHYMAR
MQ
TL
R
L
D
G
F
LL
R
P
L
L
S
L
FS
SL
I
L
CG
LL
M
L
F
G
F
S
---
A
S
G
TIE
V
G
V
L
Y
A
F
I
SYLG
R
L
NE
PL
IE
LT
TQ
-------
Q
A
ML
Q
Q
AV
V
A
GERV
F
E
L
M
DG
P
R
QQ
-----
Y
GNDD
R
PLQ
S
GT
-
-
I
E
VD
NV
S
F
A
Y
-
RD
D
N
LV
LKNINL
S
V
P
S
R
NF
VALVG
H
TGSGKSTLASL
L
M
G
YY
P
L
T
EGEIR
L
DG
R
PL
SS
L
S
H
S
A
LR
QG
VAMV
Q
Q
D
P
V
VL
ADT
FLA
N
VT
LG
-
-RDI
SEER
VW
Q
A
LE
T
V
QLA
E
L
A
RS
M
SD
G
I
Y
T
P
LGE
Q
G
N
N
LS
V
GQKQ
LL
A
L
AR
V
L
V
ETPQ
ILILDEAT
AS
ID
SG
TE
Q
AIQHAL
AAVR
E
H
T
T
L
V
VIAHRLSTI
V
DAD
T
I
L
VL
HR
G
Q
A
VE
Q
GTH
QQ
LL
AAQ
G
R
Y
W
QMYQ
L
Q
LA
GEELAASVR
E
EESLSA
fig|331112.6.peg.514
Escherichia coli HS
MRSFSQLW
P
T
LK
RL
LAYGSP
W
--------
-
R
KPL
G
I
A
V
LMM
WV
A
AAA-
--
E
V
SG
P
LLISYFI
D
N
MVAKNN
L
PLK
V
V
A
G
LA
AA
Y
VGL
QL
FAAG
L
----
---
-
--H
Y
AQ
S
L
L
FNR
A
AVG
VV
QQ
LR
T
D
VMDAAL
RQP
L
S
E
FD
T
Q
P
V
G
Q
V
ISR
V
TND
T
E
VIRDLYV
T
VV
A-------
TV
L
R
SA
ALV
G
A
---
M
L
V
A
MF
SL
D
W
RM
---
A
L
V
A
I
M
I
F
PVV
LV
VMVIYQ
R
YSTP
IV
R
RVR
A
YLA
D
I
ND
----
G
FNE
I
IN
G
MSV
I
QQ
F
R
-----------
QQA
R
FGERMGEASRSHYMAR
MQ
TL
R
L
D
G
F
LL
R
P
L
L
S
L
FS
SL
I
L
CG
LL
M
L
F
G
F
S
---
A
S
G
TIE
V
G
V
L
Y
A
F
I
SYLG
R
L
NE
PL
IE
LT
TQ
-------
Q
A
ML
Q
Q
AV
V
A
GERV
F
E
L
M
DG
P
R
QQ
-----
Y
GNDD
R
PLQ
S
GT
-
-
I
E
VD
NV
S
F
A
Y
-
RD
D
N
LV
LKNINL
S
V
P
S
R
NF
VALVG
H
TGSGKSTLASL
L
M
G
YY
P
L
T
EGEIR
L
DG
R
PL
SS
L
S
H
S
A
LR
QG
VAMV
Q
Q
D
P
V
VL
ADT
FLA
N
VT
LG
-
-RDI
SEER
VW
Q
A
LE
T
V
QLA
E
L
A
RS
M
SD
G
I
Y
T
P
LGE
Q
G
N
N
LS
V
GQKQ
LL
A
L
AR
V
L
V
ETPQ
ILILDEAT
AS
ID
SG
TE
Q
AIQHAL
AAVR
E
H
T
T
L
V
VIAHRLSTI
V
DAD
T
I
L
VL
HR
G
Q
A
VE
Q
GTH
QQ
LL
AAQ
G
R
Y
W
QMYQ
L
Q
LA
GEELAASVR
E
EESLSA
fig|83333.1.peg.446
Escherichia coli K12
MRSFSQLW
P
T
LK
RL
LAYGSP
W
--------
-
R
KPL
G
I
A
V
LMM
WV
A
AAA-
--
E
V
SG
P
LLISYFI
D
N
MVAKNN
L
PLK
V
V
A
G
LA
AA
Y
VGL
QL
FAAG
L
----
---
-
--H
Y
AQ
S
L
L
FNR
A
AVG
VV
QQ
LR
T
D
VMDAAL
RQP
L
S
E
FD
T
Q
P
V
G
Q
V
ISR
V
TND
T
E
VIRDLYV
T
VV
A-------
TV
L
R
SA
ALV
G
A
---
M
L
V
A
MF
SL
D
W
RM
---
A
L
V
A
I
M
I
F
PVV
LV
VMVIYQ
R
YSTP
IV
R
RVR
A
YLA
D
I
ND
----
G
FNE
I
IN
G
MSV
I
QQ
F
R
-----------
QQA
R
FGERMGEASRSHYMAR
MQ
TL
R
L
D
G
F
LL
R
P
L
L
S
L
FS
SL
I
L
CG
LL
M
L
F
G
F
S
---
A
S
G
TIE
V
G
V
L
Y
A
F
I
SYLG
R
L
NE
PL
IE
LT
TQ
-------
Q
A
ML
Q
Q
AV
V
A
GERV
F
E
L
M
DG
P
R
QQ
-----
Y
GNDD
R
PLQ
S
GT
-
-
I
E
VD
NV
S
F
A
Y
-
RD
D
N
LV
LKNINL
S
V
P
S
R
NF
VALVG
H
TGSGKSTLASL
L
M
G
YY
P
L
T
EGEIR
L
DG
R
PL
SS
L
S
H
S
A
LR
QG
VAMV
Q
Q
D
P
V
VL
ADT
FLA
N
VT
LG
-
-RDI
SEER
VW
Q
A
LE
T
V
QLA
E
L
A
RS
M
SD
G
I
Y
T
P
LGE
Q
G
N
N
LS
V
GQKQ
LL
A
L
AR
V
L
V
ETPQ
ILILDEAT
AS
ID
SG
TE
Q
AIQHAL
AAVR
E
H
T
T
L
V
VIAHRLSTI
V
DAD
T
I
L
VL
HR
G
Q
A
VE
Q
GTH
QQ
LL
AAQ
G
R
Y
W
QMYQ
L
Q
LA
GEELAASVR
E
EESLSA
fig|749538.3.peg.1388
Escherichia coli MS 116-1
MRSFSQLW
P
T
LK
RL
LAYGSP
W
--------
-
R
KPL
G
I
A
V
LMM
WV
A
AAA-
--
E
V
SG
P
LLISYFI
D
N
MVAKNN
L
PLK
V
V
A
G
LA
AA
Y
VGL
QL
FAAG
L
----
---
-
--H
Y
AQ
S
L
L
FNR
A
AVG
VV
QQ
LR
T
D
VMDAAL
RQP
L
S
E
FD
T
Q
P
V
G
Q
V
ISR
V
TND
T
E
VIRDLYV
T
VV
A-------
TV
L
R
SA
ALV
G
A
---
M
L
V
A
MF
SL
D
W
RM
---
A
L
V
A
I
M
I
F
PVV
LV
VMVIYQ
R
YSTP
IV
R
RVR
A
YLA
D
I
ND
----
G
FNE
I
IN
G
MSV
I
QQ
F
R
-----------
QQA
R
FGERMGEASRSHYMAR
MQ
TL
R
L
D
G
F
LL
R
P
L
L
S
L
FS
SL
I
L
CG
LL
M
L
F
G
F
S
---
A
S
G
TIE
V
G
V
L
Y
A
F
I
SYLG
R
L
NE
PL
IE
LT
TQ
-------
Q
A
ML
Q
Q
AV
V
A
GERV
F
E
L
M
DG
P
R
QQ
-----
Y
GNDD
R
PLQ
S
GT
-
-
I
E
VD
NV
S
F
A
Y
-
RD
D
N
LV
LKNINL
S
V
P
S
R
NF
VALVG
H
TGSGKSTLASL
L
M
G
YY
P
L
T
EGEIR
L
DG
R
PL
SS
L
S
H
S
A
LR
QG
VAMV
Q
Q
D
P
V
VL
ADT
FLA
N
VT
LG
-
-RDI
SEER
VW
Q
A
LE
T
V
QLA
E
L
A
RS
M
SD
G
I
Y
T
P
LGE
Q
G
N
N
LS
V
GQKQ
LL
A
L
AR
V
L
V
ETPQ
ILILDEAT
AS
ID
SG
TE
Q
AIQHAL
AAVR
E
H
T
T
L
V
VIAHRLSTI
V
DAD
T
I
L
VL
HR
G
Q
A
VE
Q
GTH
QQ
LL
AAQ
G
R
Y
W
QMYQ
L
Q
LA
GEELAASVR
E
EESLSA
fig|749546.3.peg.3559
Escherichia coli MS 185-1
MRSFSQLW
P
T
LK
RL
LAYGSP
W
--------
-
R
KPL
G
I
A
V
LMM
WV
A
AAA-
--
E
V
SG
P
LLISYFI
D
N
MVAKNN
L
PLK
V
V
A
G
LA
AA
Y
VGL
QL
FAAG
L
----
---
-
--H
Y
AQ
S
L
L
FNR
A
AVG
VV
QQ
LR
T
D
VMDAAL
RQP
L
S
E
FD
T
Q
P
V
G
Q
V
ISR
V
TND
T
E
VIRDLYV
T
VV
A-------
TV
L
R
SA
ALV
G
A
---
M
L
V
A
MF
SL
D
W
RM
---
A
L
V
A
I
M
I
F
PVV
LV
VMVIYQ
R
YSTP
IV
R
RVR
A
YLA
D
I
ND
----
G
FNE
I
IN
G
MSV
I
QQ
F
R
-----------
QQA
R
FGERMGEASRSHYMAR
MQ
TL
R
L
D
G
F
LL
R
P
L
L
S
L
FS
SL
I
L
CG
LL
M
L
F
G
F
S
---
A
S
G
TIE
V
G
V
L
Y
A
F
I
SYLG
R
L
NE
PL
IE
LT
TQ
-------
Q
A
ML
Q
Q
AV
V
A
GERV
F
E
L
M
DG
P
R
QQ
-----
Y
GNDD
R
PLQ
S
GT
-
-
I
E
VD
NV
S
F
A
Y
-
RD
D
N
LV
LKNINL
S
V
P
S
R
NF
VALVG
H
TGSGKSTLASL
L
M
G
YY
P
L
T
EGEIR
L
DG
R
PL
SS
L
S
H
S
A
LR
QG
VAMV
Q
Q
D
P
V
VL
ADT
FLA
N
VT
LG
-
-RDI
SEER
VW
Q
A
LE
T
V
QLA
E
L
A
RS
M
SD
G
I
Y
T
P
LGE
Q
G
N
N
LS
V
GQKQ
LL
A
L
AR
V
L
V
ETPQ
ILILDEAT
AS
ID
SG
TE
Q
AIQHAL
AAVR
E
H
T
T
L
V
VIAHRLSTI
V
DAD
T
I
L
VL
HR
G
Q
A
VE
Q
GTH
QQ
LL
AAQ
G
R
Y
W
QMYQ
L
Q
LA
GEELAASVR
E
EESLSA
fig|749548.3.peg.2605
Escherichia coli MS 196-1
MRSFSQLW
P
T
LK
RL
LAYGSP
W
--------
-
R
KPL
G
I
A
V
LMM
WV
A
AAA-
--
E
V
SG
P
LLISYFI
D
N
MVAKNN
L
PLK
V
V
A
G
LA
AA
Y
VGL
QL
FAAG
L
----
---
-
--H
Y
AQ
S
L
L
FNR
A
AVG
VV
QQ
LR
T
D
VMDAAL
RQP
L
S
E
FD
T
Q
P
V
G
Q
V
ISR
V
TND
T
E
VIRDLYV
T
VV
A-------
TV
L
R
SA
ALV
G
A
---
M
L
V
A
MF
SL
D
W
RM
---
A
L
V
A
I
M
I
F
PVV
LV
VMVIYQ
R
YSTP
IV
R
RVR
A
YLA
D
I
ND
----
G
FNE
I
IN
G
MSV
I
QQ
F
R
-----------
QQA
R
FGERMGEASRSHYMAR
MQ
TL
R
L
D
G
F
LL
R
P
L
L
S
L
FS
SL
I
L
CG
LL
M
L
F
G
F
S
---
A
S
G
TIE
V
G
V
L
Y
A
F
I
SYLG
R
L
NE
PL
IE
LT
TQ
-------
Q
A
ML
Q
Q
AV
V
A
GERV
F
E
L
M
DG
P
R
QQ
-----
Y
GNDD
R
PLQ
S
GT
-
-
I
E
VD
NV
S
F
A
Y
-
RD
D
N
LV
LKNINL
S
V
P
S
R
NF
VALVG
H
TGSGKSTLASL
L
M
G
YY
P
L
T
EGEIR
L
DG
R
PL
SS
L
S
H
S
A
LR
QG
VAMV
Q
Q
D
P
V
VL
ADT
FLA
N
VT
LG
-
-RDI
SEER
VW
Q
A
LE
T
V
QLA
E
L
A
RS
M
SD
G
I
Y
T
P
LGE
Q
G
N
N
LS
V
GQKQ
LL
A
L
AR
V
L
V
ETPQ
ILILDEAT
AS
ID
SG
TE
Q
AIQHAL
AAVR
E
H
T
T
L
V
VIAHRLSTI
V
DAD
T
I
L
VL
HR
G
Q
A
VE
Q
GTH
QQ
LL
AAQ
G
R
Y
W
QMYQ
L
Q
LA
GEELAASVR
E
EESLSA
fig|749549.3.peg.4323
Escherichia coli MS 198-1
MRSFSQLW
P
T
LK
RL
LAYGSP
W
--------
-
R
KPL
G
I
A
V
LMM
WV
A
AAA-
--
E
V
SG
P
LLISYFI
D
N
MVAKNN
L
PLK
V
V
A
G
LA
AA
Y
VGL
QL
FAAG
L
----
---
-
--H
Y
AQ
S
L
L
FNR
A
AVG
VV
QQ
LR
T
D
VMDAAL
RQP
L
S
E
FD
T
Q
P
V
G
Q
V
ISR
V
TND
T
E
VIRDLYV
T
VV
A-------
TV
L
R
SA
ALV
G
A
---
M
L
V
A
MF
SL
D
W
RM
---
A
L
V
A
I
M
I
F
PVV
LV
VMVIYQ
R
YSTP
IV
R
RVR
A
YLA
D
I
ND
----
G
FNE
I
IN
G
MSV
I
QQ
F
R
-----------
QQA
R
FGERMGEASRSHYMAR
MQ
TL
R
L
D
G
F
LL
R
P
L
L
S
L
FS
SL
I
L
CG
LL
M
L
F
G
F
S
---
A
S
G
TIE
V
G
V
L
Y
A
F
I
SYLG
R
L
NE
PL
IE
LT
TQ
-------
Q
A
ML
Q
Q
AV
V
A
GERV
F
E
L
M
DG
P
R
QQ
-----
Y
GNDD
R
PLQ
S
GT
-
-
I
E
VD
NV
S
F
A
Y
-
RD
D
N
LV
LKNINL
S
V
P
S
R
NF
VALVG
H
TGSGKSTLASL
L
M
G
YY
P
L
T
EGEIR
L
DG
R
PL
SS
L
S
H
S
A
LR
QG
VAMV
Q
Q
D
P
V
VL
ADT
FLA
N
VT
LG
-
-RDI
SEER
VW
Q
A
LE
T
V
QLA
E
L
A
RS
M
SD
G
I
Y
T
P
LGE
Q
G
N
N
LS
V
GQKQ
LL
A
L
AR
V
L
V
ETPQ
ILILDEAT
AS
ID
SG
TE
Q
AIQHAL
AAVR
E
H
T
T
L
V
VIAHRLSTI
V
DAD
T
I
L
VL
HR
G
Q
A
VE
Q
GTH
QQ
LL
AAQ
G
R
Y
W
QMYQ
L
Q
LA
GEELAASVR
E
EESLSA
fig|749528.3.peg.3610
Escherichia coli MS 45-1
MRSFSQLW
P
T
LK
RL
LAYGSP
W
--------
-
R
KPL
G
I
A
V
LMM
WV
A
AAA-
--
E
V
SG
P
LLISYFI
D
N
MVAKNN
L
PLK
V
V
A
G
LA
AA
Y
VGL
QL
FAAG
L
----
---
-
--H
Y
AQ
S
L
L
FNR
A
AVG
VV
QQ
LR
T
D
VMDAAL
RQP
L
S
E
FD
T
Q
P
V
G
Q
V
ISR
V
TND
T
E
VIRDLYV
T
VV
A-------
TV
L
R
SA
ALV
G
A
---
M
L
V
A
MF
SL
D
W
RM
---
A
L
V
A
I
M
I
F
PVV
LV
VMVIYQ
R
YSTP
IV
R
RVR
A
YLA
D
I
ND
----
G
FNE
I
IN
G
MSV
I
QQ
F
R
-----------
QQA
R
FGERMGEASRSHYMAR
MQ
TL
R
L
D
G
F
LL
R
P
L
L
S
L
FS
SL
I
L
CG
LL
M
L
F
G
F
S
---
A
S
G
TIE
V
G
V
L
Y
A
F
I
SYLG
R
L
NE
PL
IE
LT
TQ
-------
Q
A
ML
Q
Q
AV
V
A
GERV
F
E
L
M
DG
P
R
QQ
-----
Y
GNDD
R
PLQ
S
GT
-
-
I
E
VD
NV
S
F
A
Y
-
RD
D
N
LV
LKNINL
S
V
P
S
R
NF
VALVG
H
TGSGKSTLASL
L
M
G
YY
P
L
T
EGEIR
L
DG
R
PL
SS
L
S
H
S
A
LR
QG
VAMV
Q
Q
D
P
V
VL
ADT
FLA
N
VT
LG
-
-RDI
SEER
VW
Q
A
LE
T
V
QLA
E
L
A
RS
M
SD
G
I
Y
T
P
LGE
Q
G
N
N
LS
V
GQKQ
LL
A
L
AR
V
L
V
ETPQ
ILILDEAT
AS
ID
SG
TE
Q
AIQHAL
AAVR
E
H
T
T
L
V
VIAHRLSTI
V
DAD
T
I
L
VL
HR
G
Q
A
VE
Q
GTH
QQ
LL
AAQ
G
R
Y
W
QMYQ
L
Q
LA
GEELAASVR
E
EESLSA
fig|83334.1.peg.580
Escherichia coli O157:H7
MRSFSQLW
P
T
LK
RL
LAYGSP
W
--------
-
R
KPL
G
I
A
V
LMM
WV
A
AAA-
--
E
V
SG
P
LLISYFI
D
N
MVAKNN
L
PLK
V
V
A
G
LA
AA
Y
VGL
QL
FAAG
L
----
---
-
--H
Y
AQ
S
L
L
FNR
A
AVG
VV
QQ
LR
T
D
VMDAAL
RQP
L
S
E
FD
T
Q
P
V
G
Q
V
ISR
V
TND
T
E
VIRDLYV
T
VV
A-------
TV
L
R
SA
ALV
G
A
---
M
L
V
A
MF
SL
D
W
RM
---
A
L
V
A
I
M
I
F
PVV
LV
VMVIYQ
R
YSTP
IV
R
RVR
A
YLA
D
I
ND
----
G
FNE
I
IN
G
MSV
I
QQ
F
R
-----------
QQA
R
FGERMGEASRSHYMAR
MQ
TL
R
L
D
G
F
LL
R
P
L
L
S
L
FS
SL
I
L
CG
LL
M
L
F
G
F
S
---
A
S
G
TIE
V
G
V
L
Y
A
F
I
SYLG
R
L
NE
PL
IE
LT
TQ
-------
Q
A
ML
Q
Q
AV
V
A
GERV
F
E
L
M
DG
P
R
QQ
-----
Y
GNDD
R
PLQ
S
GT
-
-
I
E
VD
NV
S
F
A
Y
-
RD
D
N
LV
LKNINL
S
V
P
S
R
NF
VALVG
H
TGSGKSTLASL
L
M
G
YY
P
L
T
EGEIR
L
DG
R
PL
SS
L
S
H
S
A
LR
QG
VAMV
Q
Q
D
P
V
VL
ADT
FLA
N
VT
LG
-
-RDI
SEER
VW
Q
A
LE
T
V
QLA
E
L
A
RS
M
SD
G
I
Y
T
P
LGE
Q
G
N
N
LS
V
GQKQ
LL
A
L
AR
V
L
V
ETPQ
ILILDEAT
AS
ID
SG
TE
Q
AIQHAL
AAVR
E
H
T
T
L
V
VIAHRLSTI
V
DAD
T
I
L
VL
HR
G
Q
A
VE
Q
GTH
QQ
LL
AAQ
G
R
Y
W
QMYQ
L
Q
LA
GEELAASVR
E
EESLSA
fig|155864.1.peg.499
Escherichia coli O157:H7 EDL933
MRSFSQLW
P
T
LK
RL
LAYGSP
W
--------
-
R
KPL
G
I
A
V
LMM
WV
A
AAA-
--
E
V
SG
P
LLISYFI
D
N
MVAKNN
L
PLK
V
V
A
G
LA
AA
Y
VGL
QL
FAAG
L
----
---
-
--H
Y
AQ
S
L
L
FNR
A
AVG
VV
QQ
LR
T
D
VMDAAL
RQP
L
S
E
FD
T
Q
P
V
G
Q
V
ISR
V
TND
T
E
VIRDLYV
T
VV
A-------
TV
L
R
SA
ALV
G
A
---
M
L
V
A
MF
SL
D
W
RM
---
A
L
V
A
I
M
I
F
PVV
LV
VMVIYQ
R
YSTP
IV
R
RVR
A
YLA
D
I
ND
----
G
FNE
I
IN
G
MSV
I
QQ
F
R
-----------
QQA
R
FGERMGEASRSHYMAR
MQ
TL
R
L
D
G
F
LL
R
P
L
L
S
L
FS
SL
I
L
CG
LL
M
L
F
G
F
S
---
A
S
G
TIE
V
G
V
L
Y
A
F
I
SYLG
R
L
NE
PL
IE
LT
TQ
-------
Q
A
ML
Q
Q
AV
V
A
GERV
F
E
L
M
DG
P
R
QQ
-----
Y
GNDD
R
PLQ
S
GT
-
-
I
E
VD
NV
S
F
A
Y
-
RD
D
N
LV
LKNINL
S
V
P
S
R
NF
VALVG
H
TGSGKSTLASL
L
M
G
YY
P
L
T
EGEIR
L
DG
R
PL
SS
L
S
H
S
A
LR
QG
VAMV
Q
Q
D
P
V
VL
ADT
FLA
N
VT
LG
-
-RDI
SEER
VW
Q
A
LE
T
V
QLA
E
L
A
RS
M
SD
G
I
Y
T
P
LGE
Q
G
N
N
LS
V
GQKQ
LL
A
L
AR
V
L
V
ETPQ
ILILDEAT
AS
ID
SG
TE
Q
AIQHAL
AAVR
E
H
T
T
L
V
VIAHRLSTI
V
DAD
T
I
L
VL
HR
G
Q
A
VE
Q
GTH
QQ
LL
AAQ
G
R
Y
W
QMYQ
L
Q
LA
GEELAASVR
E
EESLSA
fig|155864.8.peg.507
Escherichia coli O157:H7 EDL933
MRSFSQLW
P
T
LK
RL
LAYGSP
W
--------
-
R
KPL
G
I
A
V
LMM
WV
A
AAA-
--
E
V
SG
P
LLISYFI
D
N
MVAKNN
L
PLK
V
V
A
G
LA
AA
Y
VGL
QL
FAAG
L
----
---
-
--H
Y
AQ
S
L
L
FNR
A
AVG
VV
QQ
LR
T
D
VMDAAL
RQP
L
S
E
FD
T
Q
P
V
G
Q
V
ISR
V
TND
T
E
VIRDLYV
T
VV
A-------
TV
L
R
SA
ALV
G
A
---
M
L
V
A
MF
SL
D
W
RM
---
A
L
V
A
I
M
I
F
PVV
LV
VMVIYQ
R
YSTP
IV
R
RVR
A
YLA
D
I
ND
----
G
FNE
I
IN
G
MSV
I
QQ
F
R
-----------
QQA
R
FGERMGEASRSHYMAR
MQ
TL
R
L
D
G
F
LL
R
P
L
L
S
L
FS
SL
I
L
CG
LL
M
L
F
G
F
S
---
A
S
G
TIE
V
G
V
L
Y
A
F
I
SYLG
R
L
NE
PL
IE
LT
TQ
-------
Q
A
ML
Q
Q
AV
V
A
GERV
F
E
L
M
DG
P
R
QQ
-----
Y
GNDD
R
PLQ
S
GT
-
-
I
E
VD
NV
S
F
A
Y
-
RD
D
N
LV
LKNINL
S
V
P
S
R
NF
VALVG
H
TGSGKSTLASL
L
M
G
YY
P
L
T
EGEIR
L
DG
R
PL
SS
L
S
H
S
A
LR
QG
VAMV
Q
Q
D
P
V
VL
ADT
FLA
N
VT
LG
-
-RDI
SEER
VW
Q
A
LE
T
V
QLA
E
L
A
RS
M
SD
G
I
Y
T
P
LGE
Q
G
N
N
LS
V
GQKQ
LL
A
L
AR
V
L
V
ETPQ
ILILDEAT
AS
ID
SG
TE
Q
AIQHAL
AAVR
E
H
T
T
L
V
VIAHRLSTI
V
DAD
T
I
L
VL
HR
G
Q
A
VE
Q
GTH
QQ
LL
AAQ
G
R
Y
W
QMYQ
L
Q
LA
GEELAASVR
E
EESLSA
fig|444454.5.peg.4980
Escherichia coli O157:H7 str. EC4024
MRSFSQLW
P
T
LK
RL
LAYGSP
W
--------
-
R
KPL
G
I
A
V
LMM
WV
A
AAA-
--
E
V
SG
P
LLISYFI
D
N
MVAKNN
L
PLK
V
V
A
G
LA
AA
Y
VGL
QL
FAAG
L
----
---
-
--H
Y
AQ
S
L
L
FNR
A
AVG
VV
QQ
LR
T
D
VMDAAL
RQP
L
S
E
FD
T
Q
P
V
G
Q
V
ISR
V
TND
T
E
VIRDLYV
T
VV
A-------
TV
L
R
SA
ALV
G
A
---
M
L
V
A
MF
SL
D
W
RM
---
A
L
V
A
I
M
I
F
PVV
LV
VMVIYQ
R
YSTP
IV
R
RVR
A
YLA
D
I
ND
----
G
FNE
I
IN
G
MSV
I
QQ
F
R
-----------
QQA
R
FGERMGEASRSHYMAR
MQ
TL
R
L
D
G
F
LL
R
P
L
L
S
L
FS
SL
I
L
CG
LL
M
L
F
G
F
S
---
A
S
G
TIE
V
G
V
L
Y
A
F
I
SYLG
R
L
NE
PL
IE
LT
TQ
-------
Q
A
ML
Q
Q
AV
V
A
GERV
F
E
L
M
DG
P
R
QQ
-----
Y
GNDD
R
PLQ
S
GT
-
-
I
E
VD
NV
S
F
A
Y
-
RD
D
N
LV
LKNINL
S
V
P
S
R
NF
VALVG
H
TGSGKSTLASL
L
M
G
YY
P
L
T
EGEIR
L
DG
R
PL
SS
L
S
H
S
A
LR
QG
VAMV
Q
Q
D
P
V
VL
ADT
FLA
N
VT
LG
-
-RDI
SEER
VW
Q
A
LE
T
V
QLA
E
L
A
RS
M
SD
G
I
Y
T
P
LGE
Q
G
N
N
LS
V
GQKQ
LL
A
L
AR
V
L
V
ETPQ
ILILDEAT
AS
ID
SG
TE
Q
AIQHAL
AAVR
E
H
T
T
L
V
VIAHRLSTI
V
DAD
T
I
L
VL
HR
G
Q
A
VE
Q
GTH
QQ
LL
AAQ
G
R
Y
W
QMYQ
L
Q
LA
GEELAASVR
E
EESLSA
fig|444449.5.peg.5317
Escherichia coli O157:H7 str. EC4042
MRSFSQLW
P
T
LK
RL
LAYGSP
W
--------
-
R
KPL
G
I
A
V
LMM
WV
A
AAA-
--
E
V
SG
P
LLISYFI
D
N
MVAKNN
L
PLK
V
V
A
G
LA
AA
Y
VGL
QL
FAAG
L
----
---
-
--H
Y
AQ
S
L
L
FNR
A
AVG
VV
QQ
LR
T
D
VMDAAL
RQP
L
S
E
FD
T
Q
P
V
G
Q
V
ISR
V
TND
T
E
VIRDLYV
T
VV
A-------
TV
L
R
SA
ALV
G
A
---
M
L
V
A
MF
SL
D
W
RM
---
A
L
V
A
I
M
I
F
PVV
LV
VMVIYQ
R
YSTP
IV
R
RVR
A
YLA
D
I
ND
----
G
FNE
I
IN
G
MSV
I
QQ
F
R
-----------
QQA
R
FGERMGEASRSHYMAR
MQ
TL
R
L
D
G
F
LL
R
P
L
L
S
L
FS
SL
I
L
CG
LL
M
L
F
G
F
S
---
A
S
G
TIE
V
G
V
L
Y
A
F
I
SYLG
R
L
NE
PL
IE
LT
TQ
-------
Q
A
ML
Q
Q
AV
V
A
GERV
F
E
L
M
DG
P
R
QQ
-----
Y
GNDD
R
PLQ
S
GT
-
-
I
E
VD
NV
S
F
A
Y
-
RD
D
N
LV
LKNINL
S
V
P
S
R
NF
VALVG
H
TGSGKSTLASL
L
M
G
YY
P
L
T
EGEIR
L
DG
R
PL
SS
L
S
H
S
A
LR
QG
VAMV
Q
Q
D
P
V
VL
ADT
FLA
N
VT
LG
-
-RDI
SEER
VW
Q
A
LE
T
V
QLA
E
L
A
RS
M
SD
G
I
Y
T
P
LGE
Q
G
N
N
LS
V
GQKQ
LL
A
L
AR
V
L
V
ETPQ
ILILDEAT
AS
ID
SG
TE
Q
AIQHAL
AAVR
E
H
T
T
L
V
VIAHRLSTI
V
DAD
T
I
L
VL
HR
G
Q
A
VE
Q
GTH
QQ
LL
AAQ
G
R
Y
W
QMYQ
L
Q
LA
GEELAASVR
E
EESLSA
fig|444448.5.peg.3192
Escherichia coli O157:H7 str. EC4045
MRSFSQLW
P
T
LK
RL
LAYGSP
W
--------
-
R
KPL
G
I
A
V
LMM
WV
A
AAA-
--
E
V
SG
P
LLISYFI
D
N
MVAKNN
L
PLK
V
V
A
G
LA
AA
Y
VGL
QL
FAAG
L
----
---
-
--H
Y
AQ
S
L
L
FNR
A
AVG
VV
QQ
LR
T
D
VMDAAL
RQP
L
S
E
FD
T
Q
P
V
G
Q
V
ISR
V
TND
T
E
VIRDLYV
T
VV
A-------
TV
L
R
SA
ALV
G
A
---
M
L
V
A
MF
SL
D
W
RM
---
A
L
V
A
I
M
I
F
PVV
LV
VMVIYQ
R
YSTP
IV
R
RVR
A
YLA
D
I
ND
----
G
FNE
I
IN
G
MSV
I
QQ
F
R
-----------
QQA
R
FGERMGEASRSHYMAR
MQ
TL
R
L
D
G
F
LL
R
P
L
L
S
L
FS
SL
I
L
CG
LL
M
L
F
G
F
S
---
A
S
G
TIE
V
G
V
L
Y
A
F
I
SYLG
R
L
NE
PL
IE
LT
TQ
-------
Q
A
ML
Q
Q
AV
V
A
GERV
F
E
L
M
DG
P
R
QQ
-----
Y
GNDD
R
PLQ
S
GT
-
-
I
E
VD
NV
S
F
A
Y
-
RD
D
N
LV
LKNINL
S
V
P
S
R
NF
VALVG
H
TGSGKSTLASL
L
M
G
YY
P
L
T
EGEIR
L
DG
R
PL
SS
L
S
H
S
A
LR
QG
VAMV
Q
Q
D
P
V
VL
ADT
FLA
N
VT
LG
-
-RDI
SEER
VW
Q
A
LE
T
V
QLA
E
L
A
RS
M
SD
G
I
Y
T
P
LGE
Q
G
N
N
LS
V
GQKQ
LL
A
L
AR
V
L
V
ETPQ
ILILDEAT
AS
ID
SG
TE
Q
AIQHAL
AAVR
E
H
T
T
L
V
VIAHRLSTI
V
DAD
T
I
L
VL
HR
G
Q
A
VE
Q
GTH
QQ
LL
AAQ
G
R
Y
W
QMYQ
L
Q
LA
GEELAASVR
E
EESLSA
fig|444453.5.peg.534
Escherichia coli O157:H7 str. EC4076
MRSFSQLW
P
T
LK
RL
LAYGSP
W
--------
-
R
KPL
G
I
A
V
LMM
WV
A
AAA-
--
E
V
SG
P
LLISYFI
D
N
MVAKNN
L
PLK
V
V
A
G
LA
AA
Y
VGL
QL
FAAG
L
----
---
-
--H
Y
AQ
S
L
L
FNR
A
AVG
VV
QQ
LR
T
D
VMDAAL
RQP
L
S
E
FD
T
Q
P
V
G
Q
V
ISR
V
TND
T
E
VIRDLYV
T
VV
A-------
TV
L
R
SA
ALV
G
A
---
M
L
V
A
MF
SL
D
W
RM
---
A
L
V
A
I
M
I
F
PVV
LV
VMVIYQ
R
YSTP
IV
R
RVR
A
YLA
D
I
ND
----
G
FNE
I
IN
G
MSV
I
QQ
F
R
-----------
QQA
R
FGERMGEASRSHYMAR
MQ
TL
R
L
D
G
F
LL
R
P
L
L
S
L
FS
SL
I
L
CG
LL
M
L
F
G
F
S
---
A
S
G
TIE
V
G
V
L
Y
A
F
I
SYLG
R
L
NE
PL
IE
LT
TQ
-------
Q
A
ML
Q
Q
AV
V
A
GERV
F
E
L
M
DG
P
R
QQ
-----
Y
GNDD
R
PLQ
S
GT
-
-
I
E
VD
NV
S
F
A
Y
-
RD
D
N
LV
LKNINL
S
V
P
S
R
NF
VALVG
H
TGSGKSTLASL
L
M
G
YY
P
L
T
EGEIR
L
DG
R
PL
SS
L
S
H
S
A
LR
QG
VAMV
Q
Q
D
P
V
VL
ADT
FLA
N
VT
LG
-
-RDI
SEER
VW
Q
A
LE
T
V
QLA
E
L
A
RS
M
SD
G
I
Y
T
P
LGE
Q
G
N
N
LS
V
GQKQ
LL
A
L
AR
V
L
V
ETPQ
ILILDEAT
AS
ID
SG
TE
Q
AIQHAL
AAVR
E
H
T
T
L
V
VIAHRLSTI
V
DAD
T
I
L
VL
HR
G
Q
A
VE
Q
GTH
QQ
LL
AAQ
G
R
Y
W
QMYQ
L
Q
LA
GEELAASVR
E
EESLSA
fig|444452.5.peg.992
Escherichia coli O157:H7 str. EC4113
MRSFSQLW
P
T
LK
RL
LAYGSP
W
--------
-
R
KPL
G
I
A
V
LMM
WV
A
AAA-
--
E
V
SG
P
LLISYFI
D
N
MVAKNN
L
PLK
V
V
A
G
LA
AA
Y
VGL
QL
FAAG
L
----
---
-
--H
Y
AQ
S
L
L
FNR
A
AVG
VV
QQ
LR
T
D
VMDAAL
RQP
L
S
E
FD
T
Q
P
V
G
Q
V
ISR
V
TND
T
E
VIRDLYV
T
VV
A-------
TV
L
R
SA
ALV
G
A
---
M
L
V
A
MF
SL
D
W
RM
---
A
L
V
A
I
M
I
F
PVV
LV
VMVIYQ
R
YSTP
IV
R
RVR
A
YLA
D
I
ND
----
G
FNE
I
IN
G
MSV
I
QQ
F
R
-----------
QQA
R
FGERMGEASRSHYMAR
MQ
TL
R
L
D
G
F
LL
R
P
L
L
S
L
FS
SL
I
L
CG
LL
M
L
F
G
F
S
---
A
S
G
TIE
V
G
V
L
Y
A
F
I
SYLG
R
L
NE
PL
IE
LT
TQ
-------
Q
A
ML
Q
Q
AV
V
A
GERV
F
E
L
M
DG
P
R
QQ
-----
Y
GNDD
R
PLQ
S
GT
-
-
I
E
VD
NV
S
F
A
Y
-
RD
D
N
LV
LKNINL
S
V
P
S
R
NF
VALVG
H
TGSGKSTLASL
L
M
G
YY
P
L
T
EGEIR
L
DG
R
PL
SS
L
S
H
S
A
LR
QG
VAMV
Q
Q
D
P
V
VL
ADT
FLA
N
VT
LG
-
-RDI
SEER
VW
Q
A
LE
T
V
QLA
E
L
A
RS
M
SD
G
I
Y
T
P
LGE
Q
G
N
N
LS
V
GQKQ
LL
A
L
AR
V
L
V
ETPQ
ILILDEAT
AS
ID
SG
TE
Q
AIQHAL
AAVR
E
H
T
T
L
V
VIAHRLSTI
V
DAD
T
I
L
VL
HR
G
Q
A
VE
Q
GTH
QQ
LL
AAQ
G
R
Y
W
QMYQ
L
Q
LA
GEELAASVR
E
EESLSA
fig|444450.8.peg.654
Escherichia coli O157:H7 str. EC4115
MRSFSQLW
P
T
LK
RL
LAYGSP
W
--------
-
R
KPL
G
I
A
V
LMM
WV
A
AAA-
--
E
V
SG
P
LLISYFI
D
N
MVAKNN
L
PLK
V
V
A
G
LA
AA
Y
VGL
QL
FAAG
L
----
---
-
--H
Y
AQ
S
L
L
FNR
A
AVG
VV
QQ
LR
T
D
VMDAAL
RQP
L
S
E
FD
T
Q
P
V
G
Q
V
ISR
V
TND
T
E
VIRDLYV
T
VV
A-------
TV
L
R
SA
ALV
G
A
---
M
L
V
A
MF
SL
D
W
RM
---
A
L
V
A
I
M
I
F
PVV
LV
VMVIYQ
R
YSTP
IV
R
RVR
A
YLA
D
I
ND
----
G
FNE
I
IN
G
MSV
I
QQ
F
R
-----------
QQA
R
FGERMGEASRSHYMAR
MQ
TL
R
L
D
G
F
LL
R
P
L
L
S
L
FS
SL
I
L
CG
LL
M
L
F
G
F
S
---
A
S
G
TIE
V
G
V
L
Y
A
F
I
SYLG
R
L
NE
PL
IE
LT
TQ
-------
Q
A
ML
Q
Q
AV
V
A
GERV
F
E
L
M
DG
P
R
QQ
-----
Y
GNDD
R
PLQ
S
GT
-
-
I
E
VD
NV
S
F
A
Y
-
RD
D
N
LV
LKNINL
S
V
P
S
R
NF
VALVG
H
TGSGKSTLASL
L
M
G
YY
P
L
T
EGEIR
L
DG
R
PL
SS
L
S
H
S
A
LR
QG
VAMV
Q
Q
D
P
V
VL
ADT
FLA
N
VT
LG
-
-RDI
SEER
VW
Q
A
LE
T
V
QLA
E
L
A
RS
M
SD
G
I
Y
T
P
LGE
Q
G
N
N
LS
V
GQKQ
LL
A
L
AR
V
L
V
ETPQ
ILILDEAT
AS
ID
SG
TE
Q
AIQHAL
AAVR
E
H
T
T
L
V
VIAHRLSTI
V
DAD
T
I
L
VL
HR
G
Q
A
VE
Q
GTH
QQ
LL
AAQ
G
R
Y
W
QMYQ
L
Q
LA
GEELAASVR
E
EESLSA
fig|444451.5.peg.4618
Escherichia coli O157:H7 str. EC4196
MRSFSQLW
P
T
LK
RL
LAYGSP
W
--------
-
R
KPL
G
I
A
V
LMM
WV
A
AAA-
--
E
V
SG
P
LLISYFI
D
N
MVAKNN
L
PLK
V
V
A
G
LA
AA
Y
VGL
QL
FAAG
L
----
---
-
--H
Y
AQ
S
L
L
FNR
A
AVG
VV
QQ
LR
T
D
VMDAAL
RQP
L
S
E
FD
T
Q
P
V
G
Q
V
ISR
V
TND
T
E
VIRDLYV
T
VV
A-------
TV
L
R
SA
ALV
G
A
---
M
L
V
A
MF
SL
D
W
RM
---
A
L
V
A
I
M
I
F
PVV
LV
VMVIYQ
R
YSTP
IV
R
RVR
A
YLA
D
I
ND
----
G
FNE
I
IN
G
MSV
I
QQ
F
R
-----------
QQA
R
FGERMGEASRSHYMAR
MQ
TL
R
L
D
G
F
LL
R
P
L
L
S
L
FS
SL
I
L
CG
LL
M
L
F
G
F
S
---
A
S
G
TIE
V
G
V
L
Y
A
F
I
SYLG
R
L
NE
PL
IE
LT
TQ
-------
Q
A
ML
Q
Q
AV
V
A
GERV
F
E
L
M
DG
P
R
QQ
-----
Y
GNDD
R
PLQ
S
GT
-
-
I
E
VD
NV
S
F
A
Y
-
RD
D
N
LV
LKNINL
S
V
P
S
R
NF
VALVG
H
TGSGKSTLASL
L
M
G
YY
P
L
T
EGEIR
L
DG
R
PL
SS
L
S
H
S
A
LR
QG
VAMV
Q
Q
D
P
V
VL
ADT
FLA
N
VT
LG
-
-RDI
SEER
VW
Q
A
LE
T
V
QLA
E
L
A
RS
M
SD
G
I
Y
T
P
LGE
Q
G
N
N
LS
V
GQKQ
LL
A
L
AR
V
L
V
ETPQ
ILILDEAT
AS
ID
SG
TE
Q
AIQHAL
AAVR
E
H
T
T
L
V
VIAHRLSTI
V
DAD
T
I
L
VL
HR
G
Q
A
VE
Q
GTH
QQ
LL
AAQ
G
R
Y
W
QMYQ
L
Q
LA
GEELAASVR
E
EESLSA
fig|444447.5.peg.3366
Escherichia coli O157:H7 str. EC4206
MRSFSQLW
P
T
LK
RL
LAYGSP
W
--------
-
R
KPL
G
I
A
V
LMM
WV
A
AAA-
--
E
V
SG
P
LLISYFI
D
N
MVAKNN
L
PLK
V
V
A
G
LA
AA
Y
VGL
QL
FAAG
L
----
---
-
--H
Y
AQ
S
L
L
FNR
A
AVG
VV
QQ
LR
T
D
VMDAAL
RQP
L
S
E
FD
T
Q
P
V
G
Q
V
ISR
V
TND
T
E
VIRDLYV
T
VV
A-------
TV
L
R
SA
ALV
G
A
---
M
L
V
A
MF
SL
D
W
RM
---
A
L
V
A
I
M
I
F
PVV
LV
VMVIYQ
R
YSTP
IV
R
RVR
A
YLA
D
I
ND
----
G
FNE
I
IN
G
MSV
I
QQ
F
R
-----------
QQA
R
FGERMGEASRSHYMAR
MQ
TL
R
L
D
G
F
LL
R
P
L
L
S
L
FS
SL
I
L
CG
LL
M
L
F
G
F
S
---
A
S
G
TIE
V
G
V
L
Y
A
F
I
SYLG
R
L
NE
PL
IE
LT
TQ
-------
Q
A
ML
Q
Q
AV
V
A
GERV
F
E
L
M
DG
P
R
QQ
-----
Y
GNDD
R
PLQ
S
GT
-
-
I
E
VD
NV
S
F
A
Y
-
RD
D
N
LV
LKNINL
S
V
P
S
R
NF
VALVG
H
TGSGKSTLASL
L
M
G
YY
P
L
T
EGEIR
L
DG
R
PL
SS
L
S
H
S
A
LR
QG
VAMV
Q
Q
D
P
V
VL
ADT
FLA
N
VT
LG
-
-RDI
SEER
VW
Q
A
LE
T
V
QLA
E
L
A
RS
M
SD
G
I
Y
T
P
LGE
Q
G
N
N
LS
V
GQKQ
LL
A
L
AR
V
L
V
ETPQ
ILILDEAT
AS
ID
SG
TE
Q
AIQHAL
AAVR
E
H
T
T
L
V
VIAHRLSTI
V
DAD
T
I
L
VL
HR
G
Q
A
VE
Q
GTH
QQ
LL
AAQ
G
R
Y
W
QMYQ
L
Q
LA
GEELAASVR
E
EESLSA
fig|478004.5.peg.1362
Escherichia coli O157:H7 str. EC4401
MRSFSQLW
P
T
LK
RL
LAYGSP
W
--------
-
R
KPL
G
I
A
V
LMM
WV
A
AAA-
--
E
V
SG
P
LLISYFI
D
N
MVAKNN
L
PLK
V
V
A
G
LA
AA
Y
VGL
QL
FAAG
L
----
---
-
--H
Y
AQ
S
L
L
FNR
A
AVG
VV
QQ
LR
T
D
VMDAAL
RQP
L
S
E
FD
T
Q
P
V
G
Q
V
ISR
V
TND
T
E
VIRDLYV
T
VV
A-------
TV
L
R
SA
ALV
G
A
---
M
L
V
A
MF
SL
D
W
RM
---
A
L
V
A
I
M
I
F
PVV
LV
VMVIYQ
R
YSTP
IV
R
RVR
A
YLA
D
I
ND
----
G
FNE
I
IN
G
MSV
I
QQ
F
R
-----------
QQA
R
FGERMGEASRSHYMAR
MQ
TL
R
L
D
G
F
LL
R
P
L
L
S
L
FS
SL
I
L
CG
LL
M
L
F
G
F
S
---
A
S
G
TIE
V
G
V
L
Y
A
F
I
SYLG
R
L
NE
PL
IE
LT
TQ
-------
Q
A
ML
Q
Q
AV
V
A
GERV
F
E
L
M
DG
P
R
QQ
-----
Y
GNDD
R
PLQ
S
GT
-
-
I
E
VD
NV
S
F
A
Y
-
RD
D
N
LV
LKNINL
S
V
P
S
R
NF
VALVG
H
TGSGKSTLASL
L
M
G
YY
P
L
T
EGEIR
L
DG
R
PL
SS
L
S
H
S
A
LR
QG
VAMV
Q
Q
D
P
V
VL
ADT
FLA
N
VT
LG
-
-RDI
SEER
VW
Q
A
LE
T
V
QLA
E
L
A
RS
M
SD
G
I
Y
T
P
LGE
Q
G
N
N
LS
V
GQKQ
LL
A
L
AR
V
L
V
ETPQ
ILILDEAT
AS
ID
SG
TE
Q
AIQHAL
AAVR
E
H
T
T
L
V
VIAHRLSTI
V
DAD
T
I
L
VL
HR
G
Q
A
VE
Q
GTH
QQ
LL
AAQ
G
R
Y
W
QMYQ
L
Q
LA
GEELAASVR
E
EESLSA
fig|478005.5.peg.2395
Escherichia coli O157:H7 str. EC4486
MRSFSQLW
P
T
LK
RL
LAYGSP
W
--------
-
R
KPL
G
I
A
V
LMM
WV
A
AAA-
--
E
V
SG
P
LLISYFI
D
N
MVAKNN
L
PLK
V
V
A
G
LA
AA
Y
VGL
QL
FAAG
L
----
---
-
--H
Y
AQ
S
L
L
FNR
A
AVG
VV
QQ
LR
T
D
VMDAAL
RQP
L
S
E
FD
T
Q
P
V
G
Q
V
ISR
V
TND
T
E
VIRDLYV
T
VV
A-------
TV
L
R
SA
ALV
G
A
---
M
L
V
A
MF
SL
D
W
RM
---
A
L
V
A
I
M
I
F
PVV
LV
VMVIYQ
R
YSTP
IV
R
RVR
A
YLA
D
I
ND
----
G
FNE
I
IN
G
MSV
I
QQ
F
R
-----------
QQA
R
FGERMGEASRSHYMAR
MQ
TL
R
L
D
G
F
LL
R
P
L
L
S
L
FS
SL
I
L
CG
LL
M
L
F
G
F
S
---
A
S
G
TIE
V
G
V
L
Y
A
F
I
SYLG
R
L
NE
PL
IE
LT
TQ
-------
Q
A
ML
Q
Q
AV
V
A
GERV
F
E
L
M
DG
P
R
QQ
-----
Y
GNDD
R
PLQ
S
GT
-
-
I
E
VD
NV
S
F
A
Y
-
RD
D
N
LV
LKNINL
S
V
P
S
R
NF
VALVG
H
TGSGKSTLASL
L
M
G
YY
P
L
T
EGEIR
L
DG
R
PL
SS
L
S
H
S
A
LR
QG
VAMV
Q
Q
D
P
V
VL
ADT
FLA
N
VT
LG
-
-RDI
SEER
VW
Q
A
LE
T
V
QLA
E
L
A
RS
M
SD
G
I
Y
T
P
LGE
Q
G
N
N
LS
V
GQKQ
LL
A
L
AR
V
L
V
ETPQ
ILILDEAT
AS
ID
SG
TE
Q
AIQHAL
AAVR
E
H
T
T
L
V
VIAHRLSTI
V
DAD
T
I
L
VL
HR
G
Q
A
VE
Q
GTH
QQ
LL
AAQ
G
R
Y
W
QMYQ
L
Q
LA
GEELAASVR
E
EESLSA
fig|478006.5.peg.953
Escherichia coli O157:H7 str. EC4501
MRSFSQLW
P
T
LK
RL
LAYGSP
W
--------
-
R
KPL
G
I
A
V
LMM
WV
A
AAA-
--
E
V
SG
P
LLISYFI
D
N
MVAKNN
L
PLK
V
V
A
G
LA
AA
Y
VGL
QL
FAAG
L
----
---
-
--H
Y
AQ
S
L
L
FNR
A
AVG
VV
QQ
LR
T
D
VMDAAL
RQP
L
S
E
FD
T
Q
P
V
G
Q
V
ISR
V
TND
T
E
VIRDLYV
T
VV
A-------
TV
L
R
SA
ALV
G
A
---
M
L
V
A
MF
SL
D
W
RM
---
A
L
V
A
I
M
I
F
PVV
LV
VMVIYQ
R
YSTP
IV
R
RVR
A
YLA
D
I
ND
----
G
FNE
I
IN
G
MSV
I
QQ
F
R
-----------
QQA
R
FGERMGEASRSHYMAR
MQ
TL
R
L
D
G
F
LL
R
P
L
L
S
L
FS
SL
I
L
CG
LL
M
L
F
G
F
S
---
A
S
G
TIE
V
G
V
L
Y
A
F
I
SYLG
R
L
NE
PL
IE
LT
TQ
-------
Q
A
ML
Q
Q
AV
V
A
GERV
F
E
L
M
DG
P
R
QQ
-----
Y
GNDD
R
PLQ
S
GT
-
-
I
E
VD
NV
S
F
A
Y
-
RD
D
N
LV
LKNINL
S
V
P
S
R
NF
VALVG
H
TGSGKSTLASL
L
M
G
YY
P
L
T
EGEIR
L
DG
R
PL
SS
L
S
H
S
A
LR
QG
VAMV
Q
Q
D
P
V
VL
ADT
FLA
N
VT
LG
-
-RDI
SEER
VW
Q
A
LE
T
V
QLA
E
L
A
RS
M
SD
G
I
Y
T
P
LGE
Q
G
N
N
LS
V
GQKQ
LL
A
L
AR
V
L
V
ETPQ
ILILDEAT
AS
ID
SG
TE
Q
AIQHAL
AAVR
E
H
T
T
L
V
VIAHRLSTI
V
DAD
T
I
L
VL
HR
G
Q
A
VE
Q
GTH
QQ
LL
AAQ
G
R
Y
W
QMYQ
L
Q
LA
GEELAASVR
E
EESLSA
fig|478007.5.peg.852
Escherichia coli O157:H7 str. EC508
MRSFSQLW
P
T
LK
RL
LAYGSP
W
--------
-
R
KPL
G
I
A
V
LMM
WV
A
AAA-
--
E
V
SG
P
LLISYFI
D
N
MVAKNN
L
PLK
V
V
A
G
LA
AA
Y
VGL
QL
FAAG
L
----
---
-
--H
Y
AQ
S
L
L
FNR
A
AVG
VV
QQ
LR
T
D
VMDAAL
RQP
L
S
E
FD
T
Q
P
V
G
Q
V
ISR
V
TND
T
E
VIRDLYV
T
VV
A-------
TV
L
R
SA
ALV
G
A
---
M
L
V
A
MF
SL
D
W
RM
---
A
L
V
A
I
M
I
F
PVV
LV
VMVIYQ
R
YSTP
IV
R
RVR
A
YLA
D
I
ND
----
G
FNE
I
IN
G
MSV
I
QQ
F
R
-----------
QQA
R
FGERMGEASRSHYMAR
MQ
TL
R
L
D
G
F
LL
R
P
L
L
S
L
FS
SL
I
L
CG
LL
M
L
F
G
F
S
---
A
S
G
TIE
V
G
V
L
Y
A
F
I
SYLG
R
L
NE
PL
IE
LT
TQ
-------
Q
A
ML
Q
Q
AV
V
A
GERV
F
E
L
M
DG
P
R
QQ
-----
Y
GNDD
R
PLQ
S
GT
-
-
I
E
VD
NV
S
F
A
Y
-
RD
D
N
LV
LKNINL
S
V
P
S
R
NF
VALVG
H
TGSGKSTLASL
L
M
G
YY
P
L
T
EGEIR
L
DG
R
PL
SS
L
S
H
S
A
LR
QG
VAMV
Q
Q
D
P
V
VL
ADT
FLA
N
VT
LG
-
-RDI
SEER
VW
Q
A
LE
T
V
QLA
E
L
A
RS
M
SD
G
I
Y
T
P
LGE
Q
G
N
N
LS
V
GQKQ
LL
A
L
AR
V
L
V
ETPQ
ILILDEAT
AS
ID
SG
TE
Q
AIQHAL
AAVR
E
H
T
T
L
V
VIAHRLSTI
V
DAD
T
I
L
VL
HR
G
Q
A
VE
Q
GTH
QQ
LL
AAQ
G
R
Y
W
QMYQ
L
Q
LA
GEELAASVR
E
EESLSA
fig|478008.5.peg.1594
Escherichia coli O157:H7 str. EC869
MRSFSQLW
P
T
LK
RL
LAYGSP
W
--------
-
R
KPL
G
I
A
V
LMM
WV
A
AAA-
--
E
V
SG
P
LLISYFI
D
N
MVAKNN
L
PLK
V
V
A
G
LA
AA
Y
VGL
QL
FAAG
L
----
---
-
--H
Y
AQ
S
L
L
FNR
A
AVG
VV
QQ
LR
T
D
VMDAAL
RQP
L
S
E
FD
T
Q
P
V
G
Q
V
ISR
V
TND
T
E
VIRDLYV
T
VV
A-------
TV
L
R
SA
ALV
G
A
---
M
L
V
A
MF
SL
D
W
RM
---
A
L
V
A
I
M
I
F
PVV
LV
VMVIYQ
R
YSTP
IV
R
RVR
A
YLA
D
I
ND
----
G
FNE
I
IN
G
MSV
I
QQ
F
R
-----------
QQA
R
FGERMGEASRSHYMAR
MQ
TL
R
L
D
G
F
LL
R
P
L
L
S
L
FS
SL
I
L
CG
LL
M
L
F
G
F
S
---
A
S
G
TIE
V
G
V
L
Y
A
F
I
SYLG
R
L
NE
PL
IE
LT
TQ
-------
Q
A
ML
Q
Q
AV
V
A
GERV
F
E
L
M
DG
P
R
QQ
-----
Y
GNDD
R
PLQ
S
GT
-
-
I
E
VD
NV
S
F
A
Y
-
RD
D
N
LV
LKNINL
S
V
P
S
R
NF
VALVG
H
TGSGKSTLASL
L
M
G
YY
P
L
T
EGEIR
L
DG
R
PL
SS
L
S
H
S
A
LR
QG
VAMV
Q
Q
D
P
V
VL
ADT
FLA
N
VT
LG
-
-RDI
SEER
VW
Q
A
LE
T
V
QLA
E
L
A
RS
M
SD
G
I
Y
T
P
LGE
Q
G
N
N
LS
V
GQKQ
LL
A
L
AR
V
L
V
ETPQ
ILILDEAT
AS
ID
SG
TE
Q
AIQHAL
AAVR
E
H
T
T
L
V
VIAHRLSTI
V
DAD
T
I
L
VL
HR
G
Q
A
VE
Q
GTH
QQ
LL
AAQ
G
R
Y
W
QMYQ
L
Q
LA
GEELAASVR
E
EESLSA
fig|637388.3.peg.990
Escherichia coli O157:H7 str. FRIK2000
MRSFSQLW
P
T
LK
RL
LAYGSP
W
--------
-
R
KPL
G
I
A
V
LMM
WV
A
AAA-
--
E
V
SG
P
LLISYFI
D
N
MVAKNN
L
PLK
V
V
A
G
LA
AA
Y
VGL
QL
FAAG
L
----
---
-
--H
Y
AQ
S
L
L
FNR
A
AVG
VV
QQ
LR
T
D
VMDAAL
RQP
L
S
E
FD
T
Q
P
V
G
Q
V
ISR
V
TND
T
E
VIRDLYV
T
VV
A-------
TV
L
R
SA
ALV
G
A
---
M
L
V
A
MF
SL
D
W
RM
---
A
L
V
A
I
M
I
F
PVV
LV
VMVIYQ
R
YSTP
IV
R
RVR
A
YLA
D
I
ND
----
G
FNE
I
IN
G
MSV
I
QQ
F
R
-----------
QQA
R
FGERMGEASRSHYMAR
MQ
TL
R
L
D
G
F
LL
R
P
L
L
S
L
FS
SL
I
L
CG
LL
M
L
F
G
F
S
---
A
S
G
TIE
V
G
V
L
Y
A
F
I
SYLG
R
L
NE
PL
IE
LT
TQ
-------
Q
A
ML
Q
Q
AV
V
A
GERV
F
E
L
M
DG
P
R
QQ
-----
Y
GNDD
R
PLQ
S
GT
-
-
I
E
VD
NV
S
F
A
Y
-
RD
D
N
LV
LKNINL
S
V
P
S
R
NF
VALVG
H
TGSGKSTLASL
L
M
G
YY
P
L
T
EGEIR
L
DG
R
PL
SS
L
S
H
S
A
LR
QG
VAMV
Q
Q
D
P
V
VL
ADT
FLA
N
VT
LG
-
-RDI
SEER
VW
Q
A
LE
T
V
QLA
E
L
A
RS
M
SD
G
I
Y
T
P
LGE
Q
G
N
N
LS
V
GQKQ
LL
A
L
AR
V
L
V
ETPQ
ILILDEAT
AS
ID
SG
TE
Q
AIQHAL
AAVR
E
H
T
T
L
V
VIAHRLSTI
V
DAD
T
I
L
VL
HR
G
Q
A
VE
Q
GTH
QQ
LL
AAQ
G
R
Y
W
QMYQ
L
Q
LA
GEELAASVR
E
EESLSA
fig|570506.3.peg.2220
Escherichia coli O157:H7 str. FRIK966
MRSFSQLW
P
T
LK
RL
LAYGSP
W
--------
-
R
KPL
G
I
A
V
LMM
WV
A
AAA-
--
E
V
SG
P
LLISYFI
D
N
MVAKNN
L
PLK
V
V
A
G
LA
AA
Y
VGL
QL
FAAG
L
----
---
-
--H
Y
AQ
S
L
L
FNR
A
AVG
VV
QQ
LR
T
D
VMDAAL
RQP
L
S
E
FD
T
Q
P
V
G
Q
V
ISR
V
TND
T
E
VIRDLYV
T
VV
A-------
TV
L
R
SA
ALV
G
A
---
M
L
V
A
MF
SL
D
W
RM
---
A
L
V
A
I
M
I
F
PVV
LV
VMVIYQ
R
YSTP
IV
R
RVR
A
YLA
D
I
ND
----
G
FNE
I
IN
G
MSV
I
QQ
F
R
-----------
QQA
R
FGERMGEASRSHYMAR
MQ
TL
R
L
D
G
F
LL
R
P
L
L
S
L
FS
SL
I
L
CG
LL
M
L
F
G
F
S
---
A
S
G
TIE
V
G
V
L
Y
A
F
I
SYLG
R
L
NE
PL
IE
LT
TQ
-------
Q
A
ML
Q
Q
AV
V
A
GERV
F
E
L
M
DG
P
R
QQ
-----
Y
GNDD
R
PLQ
S
GT
-
-
I
E
VD
NV
S
F
A
Y
-
RD
D
N
LV
LKNINL
S
V
P
S
R
NF
VALVG
H
TGSGKSTLASL
L
M
G
YY
P
L
T
EGEIR
L
DG
R
PL
SS
L
S
H
S
A
LR
QG
VAMV
Q
Q
D
P
V
VL
ADT
FLA
N
VT
LG
-
-RDI
SEER
VW
Q
A
LE
T
V
QLA
E
L
A
RS
M
SD
G
I
Y
T
P
LGE
Q
G
N
N
LS
V
GQKQ
LL
A
L
AR
V
L
V
ETPQ
ILILDEAT
AS
ID
SG
TE
Q
AIQHAL
AAVR
E
H
T
T
L
V
VIAHRLSTI
V
DAD
T
I
L
VL
HR
G
Q
A
VE
Q
GTH
QQ
LL
AAQ
G
R
Y
W
QMYQ
L
Q
LA
GEELAASVR
E
EESLSA
fig|386585.9.peg.607
Escherichia coli O157:H7 str. Sakai
MRSFSQLW
P
T
LK
RL
LAYGSP
W
--------
-
R
KPL
G
I
A
V
LMM
WV
A
AAA-
--
E
V
SG
P
LLISYFI
D
N
MVAKNN
L
PLK
V
V
A
G
LA
AA
Y
VGL
QL
FAAG
L
----
---
-
--H
Y
AQ
S
L
L
FNR
A
AVG
VV
QQ
LR
T
D
VMDAAL
RQP
L
S
E
FD
T
Q
P
V
G
Q
V
ISR
V
TND
T
E
VIRDLYV
T
VV
A-------
TV
L
R
SA
ALV
G
A
---
M
L
V
A
MF
SL
D
W
RM
---
A
L
V
A
I
M
I
F
PVV
LV
VMVIYQ
R
YSTP
IV
R
RVR
A
YLA
D
I
ND
----
G
FNE
I
IN
G
MSV
I
QQ
F
R
-----------
QQA
R
FGERMGEASRSHYMAR
MQ
TL
R
L
D
G
F
LL
R
P
L
L
S
L
FS
SL
I
L
CG
LL
M
L
F
G
F
S
---
A
S
G
TIE
V
G
V
L
Y
A
F
I
SYLG
R
L
NE
PL
IE
LT
TQ
-------
Q
A
ML
Q
Q
AV
V
A
GERV
F
E
L
M
DG
P
R
QQ
-----
Y
GNDD
R
PLQ
S
GT
-
-
I
E
VD
NV
S
F
A
Y
-
RD
D
N
LV
LKNINL
S
V
P
S
R
NF
VALVG
H
TGSGKSTLASL
L
M
G
YY
P
L
T
EGEIR
L
DG
R
PL
SS
L
S
H
S
A
LR
QG
VAMV
Q
Q
D
P
V
VL
ADT
FLA
N
VT
LG
-
-RDI
SEER
VW
Q
A
LE
T
V
QLA
E
L
A
RS
M
SD
G
I
Y
T
P
LGE
Q
G
N
N
LS
V
GQKQ
LL
A
L
AR
V
L
V
ETPQ
ILILDEAT
AS
ID
SG
TE
Q
AIQHAL
AAVR
E
H
T
T
L
V
VIAHRLSTI
V
DAD
T
I
L
VL
HR
G
Q
A
VE
Q
GTH
QQ
LL
AAQ
G
R
Y
W
QMYQ
L
Q
LA
GEELAASVR
E
EESLSA
fig|544404.4.peg.519
Escherichia coli O157:H7 str. TW14359
MRSFSQLW
P
T
LK
RL
LAYGSP
W
--------
-
R
KPL
G
I
A
V
LMM
WV
A
AAA-
--
E
V
SG
P
LLISYFI
D
N
MVAKNN
L
PLK
V
V
A
G
LA
AA
Y
VGL
QL
FAAG
L
----
---
-
--H
Y
AQ
S
L
L
FNR
A
AVG
VV
QQ
LR
T
D
VMDAAL
RQP
L
S
E
FD
T
Q
P
V
G
Q
V
ISR
V
TND
T
E
VIRDLYV
T
VV
A-------
TV
L
R
SA
ALV
G
A
---
M
L
V
A
MF
SL
D
W
RM
---
A
L
V
A
I
M
I
F
PVV
LV
VMVIYQ
R
YSTP
IV
R
RVR
A
YLA
D
I
ND
----
G
FNE
I
IN
G
MSV
I
QQ
F
R
-----------
QQA
R
FGERMGEASRSHYMAR
MQ
TL
R
L
D
G
F
LL
R
P
L
L
S
L
FS
SL
I
L
CG
LL
M
L
F
G
F
S
---
A
S
G
TIE
V
G
V
L
Y
A
F
I
SYLG
R
L
NE
PL
IE
LT
TQ
-------
Q
A
ML
Q
Q
AV
V
A
GERV
F
E
L
M
DG
P
R
QQ
-----
Y
GNDD
R
PLQ
S
GT
-
-
I
E
VD
NV
S
F
A
Y
-
RD
D
N
LV
LKNINL
S
V
P
S
R
NF
VALVG
H
TGSGKSTLASL
L
M
G
YY
P
L
T
EGEIR
L
DG
R
PL
SS
L
S
H
S
A
LR
QG
VAMV
Q
Q
D
P
V
VL
ADT
FLA
N
VT
LG
-
-RDI
SEER
VW
Q
A
LE
T
V
QLA
E
L
A
RS
M
SD
G
I
Y
T
P
LGE
Q
G
N
N
LS
V
GQKQ
LL
A
L
AR
V
L
V
ETPQ
ILILDEAT
AS
ID
SG
TE
Q
AIQHAL
AAVR
E
H
T
T
L
V
VIAHRLSTI
V
DAD
T
I
L
VL
HR
G
Q
A
VE
Q
GTH
QQ
LL
AAQ
G
R
Y
W
QMYQ
L
Q
LA
GEELAASVR
E
EESLSA
fig|502346.5.peg.705
Escherichia coli O157:H7 str. TW14588
MRSFSQLW
P
T
LK
RL
LAYGSP
W
--------
-
R
KPL
G
I
A
V
LMM
WV
A
AAA-
--
E
V
SG
P
LLISYFI
D
N
MVAKNN
L
PLK
V
V
A
G
LA
AA
Y
VGL
QL
FAAG
L
----
---
-
--H
Y
AQ
S
L
L
FNR
A
AVG
VV
QQ
LR
T
D
VMDAAL
RQP
L
S
E
FD
T
Q
P
V
G
Q
V
ISR
V
TND
T
E
VIRDLYV
T
VV
A-------
TV
L
R
SA
ALV
G
A
---
M
L
V
A
MF
SL
D
W
RM
---
A
L
V
A
I
M
I
F
PVV
LV
VMVIYQ
R
YSTP
IV
R
RVR
A
YLA
D
I
ND
----
G
FNE
I
IN
G
MSV
I
QQ
F
R
-----------
QQA
R
FGERMGEASRSHYMAR
MQ
TL
R
L
D
G
F
LL
R
P
L
L
S
L
FS
SL
I
L
CG
LL
M
L
F
G
F
S
---
A
S
G
TIE
V
G
V
L
Y
A
F
I
SYLG
R
L
NE
PL
IE
LT
TQ
-------
Q
A
ML
Q
Q
AV
V
A
GERV
F
E
L
M
DG
P
R
QQ
-----
Y
GNDD
R
PLQ
S
GT
-
-
I
E
VD
NV
S
F
A
Y
-
RD
D
N
LV
LKNINL
S
V
P
S
R
NF
VALVG
H
TGSGKSTLASL
L
M
G
YY
P
L
T
EGEIR
L
DG
R
PL
SS
L
S
H
S
A
LR
QG
VAMV
Q
Q
D
P
V
VL
ADT
FLA
N
VT
LG
-
-RDI
SEER
VW
Q
A
LE
T
V
QLA
E
L
A
RS
M
SD
G
I
Y
T
P
LGE
Q
G
N
N
LS
V
GQKQ
LL
A
L
AR
V
L
V
ETPQ
ILILDEAT
AS
ID
SG
TE
Q
AIQHAL
AAVR
E
H
T
T
L
V
VIAHRLSTI
V
DAD
T
I
L
VL
HR
G
Q
A
VE
Q
GTH
QQ
LL
AAQ
G
R
Y
W
QMYQ
L
Q
LA
GEELAASVR
E
EESLSA
fig|585056.7.peg.694
Escherichia coli UMN026
MRSFSQLW
P
T
LK
RL
LAYGSP
W
--------
-
R
KPL
G
I
A
V
LMM
WV
A
AAA-
--
E
V
SG
P
LLISYFI
D
N
MVAKNN
L
PLK
V
V
A
G
LA
AA
Y
VGL
QL
FAAG
L
----
---
-
--H
Y
AQ
S
L
L
FNR
A
AVG
VV
QQ
LR
T
D
VMDAAL
RQP
L
S
E
FD
T
Q
P
V
G
Q
V
ISR
V
TND
T
E
VIRDLYV
T
VV
A-------
TV
L
R
SA
ALV
G
A
---
M
L
V
A
MF
SL
D
W
RM
---
A
L
V
A
I
M
I
F
PVV
LV
VMVIYQ
R
YSTP
IV
R
RVR
A
YLA
D
I
ND
----
G
FNE
I
IN
G
MSV
I
QQ
F
R
-----------
QQA
R
FGERMGEASRSHYMAR
MQ
TL
R
L
D
G
F
LL
R
P
L
L
S
L
FS
SL
I
L
CG
LL
M
L
F
G
F
S
---
A
S
G
TIE
V
G
V
L
Y
A
F
I
SYLG
R
L
NE
PL
IE
LT
TQ
-------
Q
A
ML
Q
Q
AV
V
A
GERV
F
E
L
M
DG
P
R
QQ
-----
Y
GNDD
R
PLQ
S
GT
-
-
I
E
VD
NV
S
F
A
Y
-
RD
D
N
LV
LKNINL
S
V
P
S
R
NF
VALVG
H
TGSGKSTLASL
L
M
G
YY
P
L
T
EGEIR
L
DG
R
PL
SS
L
S
H
S
A
LR
QG
VAMV
Q
Q
D
P
V
VL
ADT
FLA
N
VT
LG
-
-RDI
SEER
VW
Q
A
LE
T
V
QLA
E
L
A
RS
M
SD
G
I
Y
T
P
LGE
Q
G
N
N
LS
V
GQKQ
LL
A
L
AR
V
L
V
ETPQ
ILILDEAT
AS
ID
SG
TE
Q
AIQHAL
AAVR
E
H
T
T
L
V
VIAHRLSTI
V
DAD
T
I
L
VL
HR
G
Q
A
VE
Q
GTH
QQ
LL
AAQ
G
R
Y
W
QMYQ
L
Q
LA
GEELAASVR
E
EESLSA
fig|316407.3.peg.435
Escherichia coli W3110
MRSFSQLW
P
T
LK
RL
LAYGSP
W
--------
-
R
KPL
G
I
A
V
LMM
WV
A
AAA-
--
E
V
SG
P
LLISYFI
D
N
MVAKNN
L
PLK
V
V
A
G
LA
AA
Y
VGL
QL
FAAG
L
----
---
-
--H
Y
AQ
S
L
L
FNR
A
AVG
VV
QQ
LR
T
D
VMDAAL
RQP
L
S
E
FD
T
Q
P
V
G
Q
V
ISR
V
TND
T
E
VIRDLYV
T
VV
A-------
TV
L
R
SA
ALV
G
A
---
M
L
V
A
MF
SL
D
W
RM
---
A
L
V
A
I
M
I
F
PVV
LV
VMVIYQ
R
YSTP
IV
R
RVR
A
YLA
D
I
ND
----
G
FNE
I
IN
G
MSV
I
QQ
F
R
-----------
QQA
R
FGERMGEASRSHYMAR
MQ
TL
R
L
D
G
F
LL
R
P
L
L
S
L
FS
SL
I
L
CG
LL
M
L
F
G
F
S
---
A
S
G
TIE
V
G
V
L
Y
A
F
I
SYLG
R
L
NE
PL
IE
LT
TQ
-------
Q
A
ML
Q
Q
AV
V
A
GERV
F
E
L
M
DG
P
R
QQ
-----
Y
GNDD
R
PLQ
S
GT
-
-
I
E
VD
NV
S
F
A
Y
-
RD
D
N
LV
LKNINL
S
V
P
S
R
NF
VALVG
H
TGSGKSTLASL
L
M
G
YY
P
L
T
EGEIR
L
DG
R
PL
SS
L
S
H
S
A
LR
QG
VAMV
Q
Q
D
P
V
VL
ADT
FLA
N
VT
LG
-
-RDI
SEER
VW
Q
A
LE
T
V
QLA
E
L
A
RS
M
SD
G
I
Y
T
P
LGE
Q
G
N
N
LS
V
GQKQ
LL
A
L
AR
V
L
V
ETPQ
ILILDEAT
AS
ID
SG
TE
Q
AIQHAL
AAVR
E
H
T
T
L
V
VIAHRLSTI
V
DAD
T
I
L
VL
HR
G
Q
A
VE
Q
GTH
QQ
LL
AAQ
G
R
Y
W
QMYQ
L
Q
LA
GEELAASVR
E
EESLSA
fig|316385.5.peg.404
Escherichia coli str. K-12 substr. DH10B
MRSFSQLW
P
T
LK
RL
LAYGSP
W
--------
-
R
KPL
G
I
A
V
LMM
WV
A
AAA-
--
E
V
SG
P
LLISYFI
D
N
MVAKNN
L
PLK
V
V
A
G
LA
AA
Y
VGL
QL
FAAG
L
----
---
-
--H
Y
AQ
S
L
L
FNR
A
AVG
VV
QQ
LR
T
D
VMDAAL
RQP
L
S
E
FD
T
Q
P
V
G
Q
V
ISR
V
TND
T
E
VIRDLYV
T
VV
A-------
TV
L
R
SA
ALV
G
A
---
M
L
V
A
MF
SL
D
W
RM
---
A
L
V
A
I
M
I
F
PVV
LV
VMVIYQ
R
YSTP
IV
R
RVR
A
YLA
D
I
ND
----
G
FNE
I
IN
G
MSV
I
QQ
F
R
-----------
QQA
R
FGERMGEASRSHYMAR
MQ
TL
R
L
D
G
F
LL
R
P
L
L
S
L
FS
SL
I
L
CG
LL
M
L
F
G
F
S
---
A
S
G
TIE
V
G
V
L
Y
A
F
I
SYLG
R
L
NE
PL
IE
LT
TQ
-------
Q
A
ML
Q
Q
AV
V
A
GERV
F
E
L
M
DG
P
R
QQ
-----
Y
GNDD
R
PLQ
S
GT
-
-
I
E
VD
NV
S
F
A
Y
-
RD
D
N
LV
LKNINL
S
V
P
S
R
NF
VALVG
H
TGSGKSTLASL
L
M
G
YY
P
L
T
EGEIR
L
DG
R
PL
SS
L
S
H
S
A
LR
QG
VAMV
Q
Q
D
P
V
VL
ADT
FLA
N
VT
LG
-
-RDI
SEER
VW
Q
A
LE
T
V
QLA
E
L
A
RS
M
SD
G
I
Y
T
P
LGE
Q
G
N
N
LS
V
GQKQ
LL
A
L
AR
V
L
V
ETPQ
ILILDEAT
AS
ID
SG
TE
Q
AIQHAL
AAVR
E
H
T
T
L
V
VIAHRLSTI
V
DAD
T
I
L
VL
HR
G
Q
A
VE
Q
GTH
QQ
LL
AAQ
G
R
Y
W
QMYQ
L
Q
LA
GEELAASVR
E
EESLSA
fig|316385.7.peg.410
Escherichia coli str. K-12 substr. DH10B
MRSFSQLW
P
T
LK
RL
LAYGSP
W
--------
-
R
KPL
G
I
A
V
LMM
WV
A
AAA-
--
E
V
SG
P
LLISYFI
D
N
MVAKNN
L
PLK
V
V
A
G
LA
AA
Y
VGL
QL
FAAG
L
----
---
-
--H
Y
AQ
S
L
L
FNR
A
AVG
VV
QQ
LR
T
D
VMDAAL
RQP
L
S
E
FD
T
Q
P
V
G
Q
V
ISR
V
TND
T
E
VIRDLYV
T
VV
A-------
TV
L
R
SA
ALV
G
A
---
M
L
V
A
MF
SL
D
W
RM
---
A
L
V
A
I
M
I
F
PVV
LV
VMVIYQ
R
YSTP
IV
R
RVR
A
YLA
D
I
ND
----
G
FNE
I
IN
G
MSV
I
QQ
F
R
-----------
QQA
R
FGERMGEASRSHYMAR
MQ
TL
R
L
D
G
F
LL
R
P
L
L
S
L
FS
SL
I
L
CG
LL
M
L
F
G
F
S
---
A
S
G
TIE
V
G
V
L
Y
A
F
I
SYLG
R
L
NE
PL
IE
LT
TQ
-------
Q
A
ML
Q
Q
AV
V
A
GERV
F
E
L
M
DG
P
R
QQ
-----
Y
GNDD
R
PLQ
S
GT
-
-
I
E
VD
NV
S
F
A
Y
-
RD
D
N
LV
LKNINL
S
V
P
S
R
NF
VALVG
H
TGSGKSTLASL
L
M
G
YY
P
L
T
EGEIR
L
DG
R
PL
SS
L
S
H
S
A
LR
QG
VAMV
Q
Q
D
P
V
VL
ADT
FLA
N
VT
LG
-
-RDI
SEER
VW
Q
A
LE
T
V
QLA
E
L
A
RS
M
SD
G
I
Y
T
P
LGE
Q
G
N
N
LS
V
GQKQ
LL
A
L
AR
V
L
V
ETPQ
ILILDEAT
AS
ID
SG
TE
Q
AIQHAL
AAVR
E
H
T
T
L
V
VIAHRLSTI
V
DAD
T
I
L
VL
HR
G
Q
A
VE
Q
GTH
QQ
LL
AAQ
G
R
Y
W
QMYQ
L
Q
LA
GEELAASVR
E
EESLSA
fig|511145.12.peg.467
Escherichia coli str. K-12 substr. MG1655
MRSFSQLW
P
T
LK
RL
LAYGSP
W
--------
-
R
KPL
G
I
A
V
LMM
WV
A
AAA-
--
E
V
SG
P
LLISYFI
D
N
MVAKNN
L
PLK
V
V
A
G
LA
AA
Y
VGL
QL
FAAG
L
----
---
-
--H
Y
AQ
S
L
L
FNR
A
AVG
VV
QQ
LR
T
D
VMDAAL
RQP
L
S
E
FD
T
Q
P
V
G
Q
V
ISR
V
TND
T
E
VIRDLYV
T
VV
A-------
TV
L
R
SA
ALV
G
A
---
M
L
V
A
MF
SL
D
W
RM
---
A
L
V
A
I
M
I
F
PVV
LV
VMVIYQ
R
YSTP
IV
R
RVR
A
YLA
D
I
ND
----
G
FNE
I
IN
G
MSV
I
QQ
F
R
-----------
QQA
R
FGERMGEASRSHYMAR
MQ
TL
R
L
D
G
F
LL
R
P
L
L
S
L
FS
SL
I
L
CG
LL
M
L
F
G
F
S
---
A
S
G
TIE
V
G
V
L
Y
A
F
I
SYLG
R
L
NE
PL
IE
LT
TQ
-------
Q
A
ML
Q
Q
AV
V
A
GERV
F
E
L
M
DG
P
R
QQ
-----
Y
GNDD
R
PLQ
S
GT
-
-
I
E
VD
NV
S
F
A
Y
-
RD
D
N
LV
LKNINL
S
V
P
S
R
NF
VALVG
H
TGSGKSTLASL
L
M
G
YY
P
L
T
EGEIR
L
DG
R
PL
SS
L
S
H
S
A
LR
QG
VAMV
Q
Q
D
P
V
VL
ADT
FLA
N
VT
LG
-
-RDI
SEER
VW
Q
A
LE
T
V
QLA
E
L
A
RS
M
SD
G
I
Y
T
P
LGE
Q
G
N
N
LS
V
GQKQ
LL
A
L
AR
V
L
V
ETPQ
ILILDEAT
AS
ID
SG
TE
Q
AIQHAL
AAVR
E
H
T
T
L
V
VIAHRLSTI
V
DAD
T
I
L
VL
HR
G
Q
A
VE
Q
GTH
QQ
LL
AAQ
G
R
Y
W
QMYQ
L
Q
LA
GEELAASVR
E
EESLSA
fig|511145.6.peg.462
Escherichia coli str. K-12 substr. MG1655
MRSFSQLW
P
T
LK
RL
LAYGSP
W
--------
-
R
KPL
G
I
A
V
LMM
WV
A
AAA-
--
E
V
SG
P
LLISYFI
D
N
MVAKNN
L
PLK
V
V
A
G
LA
AA
Y
VGL
QL
FAAG
L
----
---
-
--H
Y
AQ
S
L
L
FNR
A
AVG
VV
QQ
LR
T
D
VMDAAL
RQP
L
S
E
FD
T
Q
P
V
G
Q
V
ISR
V
TND
T
E
VIRDLYV
T
VV
A-------
TV
L
R
SA
ALV
G
A
---
M
L
V
A
MF
SL
D
W
RM
---
A
L
V
A
I
M
I
F
PVV
LV
VMVIYQ
R
YSTP
IV
R
RVR
A
YLA
D
I
ND
----
G
FNE
I
IN
G
MSV
I
QQ
F
R
-----------
QQA
R
FGERMGEASRSHYMAR
MQ
TL
R
L
D
G
F
LL
R
P
L
L
S
L
FS
SL
I
L
CG
LL
M
L
F
G
F
S
---
A
S
G
TIE
V
G
V
L
Y
A
F
I
SYLG
R
L
NE
PL
IE
LT
TQ
-------
Q
A
ML
Q
Q
AV
V
A
GERV
F
E
L
M
DG
P
R
QQ
-----
Y
GNDD
R
PLQ
S
GT
-
-
I
E
VD
NV
S
F
A
Y
-
RD
D
N
LV
LKNINL
S
V
P
S
R
NF
VALVG
H
TGSGKSTLASL
L
M
G
YY
P
L
T
EGEIR
L
DG
R
PL
SS
L
S
H
S
A
LR
QG
VAMV
Q
Q
D
P
V
VL
ADT
FLA
N
VT
LG
-
-RDI
SEER
VW
Q
A
LE
T
V
QLA
E
L
A
RS
M
SD
G
I
Y
T
P
LGE
Q
G
N
N
LS
V
GQKQ
LL
A
L
AR
V
L
V
ETPQ
ILILDEAT
AS
ID
SG
TE
Q
AIQHAL
AAVR
E
H
T
T
L
V
VIAHRLSTI
V
DAD
T
I
L
VL
HR
G
Q
A
VE
Q
GTH
QQ
LL
AAQ
G
R
Y
W
QMYQ
L
Q
LA
GEELAASVR
E
EESLSA
fig|749527.3.peg.1904
Escherichia coli MS 21-1
MRSFSQLW
P
T
LK
RL
LAYGSP
W
--------
-
R
KPL
G
I
A
V
LMM
WV
A
AAA-
--
E
V
SG
P
LLISYFI
D
N
MVAKNN
L
PLK
V
V
A
G
LA
AA
Y
VGL
QL
FAAG
L
----
---
-
--H
Y
AQ
S
L
L
FNR
A
AVG
VV
QQ
LR
T
D
VMDAAL
RQP
L
S
E
FD
T
Q
P
V
G
Q
V
ISR
V
TND
T
E
VIRDLYV
T
VV
A-------
TV
L
R
SA
ALV
G
A
---
M
L
V
A
MF
SL
D
W
RM
---
A
L
V
A
I
M
I
F
PVV
LV
VMVIYQ
R
YSTP
IV
R
RVR
A
YLA
D
I
ND
----
G
FNE
I
IN
G
MSV
I
QQ
F
R
-----------
QQA
R
FGERMGEASRSHYMAR
MQ
TL
R
L
D
G
F
LL
R
P
L
L
S
L
FS
SL
I
L
CG
LL
M
L
F
G
F
S
---
A
S
G
TIE
V
G
V
L
Y
A
F
I
SYLG
R
L
NE
PL
IE
LT
TQ
-------
Q
A
ML
Q
Q
AV
V
A
GERV
F
E
L
M
DG
P
R
QQ
-----
Y
GNDD
R
PLQ
S
GT
-
-
I
E
VD
NV
S
F
A
Y
-
RD
D
N
M
V
LKNINL
S
V
P
S
R
NF
VALVG
H
TGSGKSTLASL
L
M
G
YY
P
L
T
EGEIR
L
DG
R
PL
SS
L
S
H
S
A
LR
QG
VAMV
Q
Q
D
P
V
VL
ADT
FLA
N
VT
LG
-
-RDI
SEER
VW
Q
A
LE
T
V
QLA
E
L
A
RS
M
SD
G
I
Y
T
P
LGE
Q
G
N
N
LS
V
GQKQ
LL
A
L
AR
V
L
V
ETPQ
ILILDEAT
AS
ID
SG
TE
Q
AIQHAL
AAVR
E
H
T
T
L
V
VIAHRLSTI
V
DAD
T
I
L
VL
HR
G
Q
A
VE
Q
GTH
QQ
LL
AAQ
G
R
Y
W
QMYQ
L
Q
LA
GEELAASVR
E
EESLSA
fig|701177.3.peg.559
Escherichia coli O55:H7 str. CB9615
MRSFSQLW
P
T
LK
RL
LAYGSP
W
--------
-
R
KPL
G
I
A
V
LMM
WV
A
AAA-
--
E
V
SG
P
LLISYFI
D
N
MVAKNN
L
PLK
V
V
A
G
LA
AA
Y
VGL
QL
FAAG
L
----
---
-
--H
Y
AQ
S
L
L
FNR
A
AVG
VV
QQ
LR
T
D
VMDAAL
RQP
L
S
E
FD
T
Q
P
V
G
Q
V
ISR
V
TND
T
E
VIRDLYV
T
VV
A-------
TV
L
R
SA
ALV
G
A
---
M
L
V
A
MF
SL
D
W
RM
---
A
L
V
A
I
M
I
F
PVV
LV
VMVIYQ
R
YSTP
IV
R
RVR
A
YMA
D
I
ND
----
G
FNE
I
IN
G
MSV
I
QQ
F
R
-----------
QQA
R
FGERMGEASRSHYMAR
MQ
TL
R
L
D
G
F
LL
R
P
L
L
S
L
FS
SL
I
L
CG
LL
M
L
F
G
F
S
---
A
S
G
TIE
V
G
V
L
Y
A
F
I
SYLG
R
L
NE
PL
IE
LT
TQ
-------
Q
A
ML
Q
Q
AV
V
A
GERV
F
E
L
M
DG
P
R
QQ
-----
Y
GNDD
R
PLQ
S
GT
-
-
I
E
VD
NV
S
F
A
Y
-
RD
D
N
LV
LKNINL
S
V
P
S
R
NF
VALVG
H
TGSGKSTLASL
L
M
G
YY
P
L
T
EGEIR
L
DG
R
PL
SS
L
S
H
S
A
LR
QG
VAMV
Q
Q
D
P
V
VL
ADT
FLA
N
VT
LG
-
-RDI
SEER
VW
Q
A
LE
T
V
QLA
E
L
A
RS
M
SD
G
I
Y
T
P
LGE
Q
G
N
N
LS
V
GQKQ
LL
A
L
AR
V
L
V
ETPQ
ILILDEAT
AS
ID
SG
TE
Q
AIQHAL
AAVR
E
H
T
T
L
V
VIAHRLSTI
V
DAD
T
I
L
VL
HR
G
Q
A
VE
Q
GTH
QQ
LL
AAQ
G
R
Y
W
QMYQ
L
Q
LA
GEELAASVR
E
EESLSA
fig|656444.3.peg.926
Escherichia coli TA280
MRSFSQLW
P
T
LK
RL
LAYGSP
W
--------
-
R
KPL
G
I
A
V
LMM
WV
A
AAA-
--
E
V
SG
P
LLISYFI
D
N
MVAKNN
L
PLK
V
V
A
G
LA
AA
Y
VGL
QL
FAAG
L
----
---
-
--H
Y
AQ
S
L
L
FNR
A
AVG
VV
QQ
LR
T
D
VMDAAL
RQP
L
S
E
FD
T
Q
P
V
G
Q
V
ISR
V
TND
T
E
VIRDLYV
T
VV
A-------
TV
L
R
SA
ALV
G
A
---
M
L
V
A
MF
SL
D
W
RM
---
A
L
V
A
I
M
I
F
PVV
LV
VMVIYQ
R
YSTP
IV
R
RVR
A
YLA
D
I
ND
----
G
FNE
I
IN
G
MSV
I
QQ
F
R
-----------
QQA
R
FGERMGEASRSHYMAR
MQ
TL
R
L
D
G
F
LL
R
P
L
L
S
L
FS
SL
I
L
CG
LL
M
L
F
G
F
S
---
A
S
G
TIE
V
G
V
L
Y
A
F
I
SYLG
R
L
NE
PL
IE
LT
TQ
-------
Q
A
MM
Q
Q
AV
V
A
GERV
F
E
L
M
DG
P
R
QQ
-----
Y
GNDD
R
PLQ
S
GT
-
-
I
E
VD
NV
S
F
A
Y
-
RD
D
N
LV
LKNINL
S
V
P
S
R
NF
VALVG
H
TGSGKSTLASL
L
M
G
YY
P
L
T
EGEIR
L
DG
R
PL
SS
L
S
H
S
A
LR
QG
VAMV
Q
Q
D
P
V
VL
ADT
FLA
N
VT
LG
-
-RDI
SEER
VW
Q
A
LE
T
V
QLA
E
L
A
RS
M
SD
G
I
Y
T
P
LGE
Q
G
N
N
LS
V
GQKQ
LL
A
L
AR
V
L
V
ETPQ
ILILDEAT
AS
ID
SG
TE
Q
AIQHAL
AAVR
E
H
T
T
L
V
VIAHRLSTI
V
DAD
T
I
L
VL
HR
G
Q
A
VE
Q
GTH
QQ
LL
AAQ
G
R
Y
W
QMYQ
L
Q
LA
GEELAASVR
E
EESLSA
fig|749531.3.peg.2798
Escherichia coli MS 69-1
MRSFSQLW
P
T
LK
RL
LAYGSP
W
--------
-
R
KPL
G
I
A
V
LMM
WV
A
AAA-
--
E
V
SG
P
LLISYFI
D
N
MVAKNN
L
PLK
V
V
A
G
LA
AA
Y
VGL
QL
FAAG
L
----
---
-
--H
Y
AQ
S
L
L
FNR
A
AVG
VV
QQ
LR
T
D
VMDAAL
RQP
L
S
E
FD
T
Q
P
V
G
Q
V
ISR
V
TND
T
E
VIRDLYV
T
VV
A-------
TV
L
R
SA
ALV
G
A
---
M
L
V
A
MF
SL
D
W
RM
---
A
L
V
A
I
M
I
F
PVV
LV
VMVIYQ
R
YSTP
IV
R
RVR
A
YLA
D
I
ND
----
G
FNE
I
IN
G
MSV
I
QQ
F
R
-----------
QQS
R
FGERMGEASRSHYMAR
MQ
TL
R
L
D
G
F
LL
R
P
L
L
S
L
FS
SL
I
L
CG
LL
M
L
F
G
F
S
---
A
S
G
TIE
V
G
V
L
Y
A
F
I
SYLG
R
L
NE
PL
IE
LT
TQ
-------
Q
A
ML
Q
Q
AV
V
A
GERV
F
E
L
M
DG
P
R
QQ
-----
Y
GNDD
R
PLQ
S
GT
-
-
I
E
VD
NV
S
F
A
Y
-
RD
D
N
LV
LKNINL
S
V
P
S
R
NF
VALVG
H
TGSGKSTLASL
L
M
G
YY
P
L
T
EGEIR
L
DG
R
PL
SS
L
S
H
S
A
LR
QG
VAMV
Q
Q
D
P
V
VL
ADT
FLA
N
VT
LG
-
-RDI
SEER
VW
Q
A
LE
T
V
QLA
E
L
A
RS
M
SD
G
I
Y
T
P
LGE
Q
G
N
N
LS
V
GQKQ
LL
A
L
AR
V
L
V
ETPQ
ILILDEAT
AS
ID
SG
TE
Q
AIQHAL
AAVR
E
H
T
T
L
V
VIAHRLSTI
V
DAD
T
I
L
VL
HR
G
Q
A
VE
Q
GTH
QQ
LL
AAQ
G
R
Y
W
QMYQ
L
Q
LA
GEELAASVR
E
EESLSA
fig|753642.3.peg.1184
Escherichia coli NC101
MRSFSQLW
P
T
LK
RL
LAYGSP
W
--------
-
R
KPL
G
I
A
V
LMM
WV
A
AAA-
--
E
V
SG
P
LLISYFI
D
N
MVAKNN
L
PLK
V
V
A
G
LA
AA
Y
VGL
QL
FAAG
L
----
---
-
--H
Y
AQ
S
L
L
FNR
A
AVG
VV
QQ
LR
T
D
VMDAAL
RQP
L
S
E
FD
T
Q
P
V
G
Q
V
ISR
V
TND
T
E
VIRDLYV
T
VV
A-------
TV
L
R
SA
ALV
G
A
---
M
L
V
A
MF
SL
D
W
RM
---
A
L
V
A
I
M
I
F
PVV
LV
VMVIYQ
R
YSTP
IV
R
RVR
A
YLA
D
I
ND
----
G
FNE
I
IN
G
MSV
I
QQ
F
R
-----------
QQA
R
FGERMGEASRSHYMAR
MQ
TL
R
L
D
G
F
LL
R
P
L
L
S
L
FS
SL
I
L
CG
LL
M
L
F
G
F
S
---
A
S
G
TIE
V
G
V
L
Y
A
F
I
SYLG
R
L
NE
PL
IE
LT
TQ
-------
Q
A
ML
Q
Q
AV
V
A
GERV
F
E
L
M
DG
P
R
QQ
-----
Y
GNDD
R
PLQ
S
GT
-
-
I
E
VD
NV
S
F
A
Y
-
RD
D
N
LV
LKNINL
S
V
P
S
R
NF
VALVG
H
TGSGKSTLASL
L
M
G
YY
P
L
T
EGEIR
L
DG
R
PL
ST
L
S
H
S
A
LR
QG
VAMV
Q
Q
D
P
V
VL
ADT
FLA
N
VT
LG
-
-RDI
SEER
VW
Q
A
LE
T
V
QLA
E
L
A
RS
M
SD
G
I
Y
T
P
LGE
Q
G
N
N
LS
V
GQKQ
LL
A
L
AR
V
L
V
ETPQ
ILILDEAT
AS
ID
SG
TE
Q
AIQHAL
AAVR
E
H
T
T
L
V
VIAHRLSTI
V
DAD
T
I
L
VL
HR
G
Q
A
VE
Q
GTH
QQ
LL
AAQ
G
R
Y
W
QMYQ
L
Q
LA
GEELAASVR
E
EESLSA
fig|550672.3.peg.471
Escherichia coli B088
MRSFSQLW
P
T
LK
RL
LAYGSP
W
--------
-
R
KPL
G
I
A
V
LMM
WV
A
AAA-
--
E
V
SG
P
LLISYFI
D
N
MVAKNN
L
PLK
M
V
A
G
LA
AA
Y
VGL
QL
FAAG
L
----
---
-
--H
Y
AQ
S
L
L
FNR
A
AVG
VV
QQ
LR
T
D
VMDAAL
RQP
L
S
E
FD
T
Q
P
V
G
Q
V
ISR
V
TND
T
E
VIRDLYV
T
VV
A-------
TV
L
R
SA
ALV
G
A
---
M
L
V
A
MF
SL
D
W
RM
---
A
L
V
A
I
M
I
F
PVV
LV
VMVIYQ
R
YSTP
IV
R
RVR
A
YLA
D
I
ND
----
G
FNE
I
IN
G
MSV
I
QQ
F
R
-----------
QQA
R
FGERMGEASRSHYMAR
MQ
TL
R
L
D
G
F
LL
R
P
L
L
S
L
FS
SL
I
L
CG
LL
M
L
F
G
F
S
---
A
S
G
TIE
V
G
V
L
Y
A
F
I
SYLG
R
L
NE
PL
IE
LT
TQ
-------
Q
A
ML
Q
Q
AV
V
A
GERV
F
E
L
M
DG
P
R
QQ
-----
Y
GNDE
R
PLQ
S
GT
-
-
I
E
VD
NV
S
F
A
Y
-
RD
D
N
LV
LKNINL
S
V
P
S
R
NF
VALVG
H
TGSGKSTLASL
L
M
G
YY
P
L
T
EGEIR
L
DG
R
PL
SS
L
S
H
S
A
LR
QG
VAMV
Q
Q
D
P
V
VL
ADT
FLA
N
VT
LG
-
-RDI
SEER
VW
Q
A
LE
T
V
QLA
E
L
A
RS
M
SD
G
I
Y
T
P
LGE
Q
G
N
N
LS
V
GQKQ
LL
A
L
AR
V
L
V
ETPQ
ILILDEAT
AS
ID
SG
TE
Q
AIQHAL
AAVR
E
H
T
T
L
V
VIAHRLSTI
V
DAD
T
I
L
VL
HR
G
Q
A
VE
Q
GTH
QQ
LL
AAQ
G
R
Y
W
QMYQ
L
Q
LA
GEELAASVR
E
EESLSA
fig|562.375.peg.3727
Escherichia coli EC4100B
MRSFSQLW
P
T
LK
RL
LAYGSP
W
--------
-
R
KPL
G
I
A
V
LMM
WV
A
AAA-
--
E
V
SG
P
LLISYFI
D
N
MVAKNN
L
PLK
M
V
A
G
LA
AA
Y
VGL
QL
FAAG
L
----
---
-
--H
Y
AQ
S
L
L
FNR
A
AVG
VV
QQ
LR
T
D
VMDAAL
RQP
L
S
E
FD
T
Q
P
V
G
Q
V
ISR
V
TND
T
E
VIRDLYV
T
VV
A-------
TV
L
R
SA
ALV
G
A
---
M
L
V
A
MF
SL
D
W
RM
---
A
L
V
A
I
M
I
F
PVV
LV
VMVIYQ
R
YSTP
IV
R
RVR
A
YLA
D
I
ND
----
G
FNE
I
IN
G
MSV
I
QQ
F
R
-----------
QQA
R
FGERMGEASRSHYMAR
MQ
TL
R
L
D
G
F
LL
R
P
L
L
S
L
FS
SL
I
L
CG
LL
M
L
F
G
F
S
---
A
S
G
TIE
V
G
V
L
Y
A
F
I
SYLG
R
L
NE
PL
IE
LT
TQ
-------
Q
A
ML
Q
Q
AV
V
A
GERV
F
E
L
M
DG
P
R
QQ
-----
Y
GNDE
R
PLQ
S
GT
-
-
I
E
VD
NV
S
F
A
Y
-
RD
D
N
LV
LKNINL
S
V
P
S
R
NF
VALVG
H
TGSGKSTLASL
L
M
G
YY
P
L
T
EGEIR
L
DG
R
PL
SS
L
S
H
S
A
LR
QG
VAMV
Q
Q
D
P
V
VL
ADT
FLA
N
VT
LG
-
-RDI
SEER
VW
Q
A
LE
T
V
QLA
E
L
A
RS
M
SD
G
I
Y
T
P
LGE
Q
G
N
N
LS
V
GQKQ
LL
A
L
AR
V
L
V
ETPQ
ILILDEAT
AS
ID
SG
TE
Q
AIQHAL
AAVR
E
H
T
T
L
V
VIAHRLSTI
V
DAD
T
I
L
VL
HR
G
Q
A
VE
Q
GTH
QQ
LL
AAQ
G
R
Y
W
QMYQ
L
Q
LA
GEELAASVR
E
EESLSA
fig|679207.4.peg.3176
Escherichia coli MS 107-1
MRSFSQLW
P
T
LK
RL
LAYGSP
W
--------
-
R
KPL
G
I
A
V
LMM
WV
A
AAA-
--
E
V
SG
P
LLISYFI
D
N
MVAKNN
L
PLK
M
V
A
G
LA
AA
Y
VGL
QL
FAAG
L
----
---
-
--H
Y
AQ
S
L
L
FNR
A
AVG
VV
QQ
LR
T
D
VMDAAL
RQP
L
S
E
FD
T
Q
P
V
G
Q
V
ISR
V
TND
T
E
VIRDLYV
T
VV
A-------
TV
L
R
SA
ALV
G
A
---
M
L
V
A
MF
SL
D
W
RM
---
A
L
V
A
I
M
I
F
PVV
LV
VMVIYQ
R
YSTP
IV
R
RVR
A
YLA
D
I
ND
----
G
FNE
I
IN
G
MSV
I
QQ
F
R
-----------
QQA
R
FGERMGEASRSHYMAR
MQ
TL
R
L
D
G
F
LL
R
P
L
L
S
L
FS
SL
I
L
CG
LL
M
L
F
G
F
S
---
A
S
G
TIE
V
G
V
L
Y
A
F
I
SYLG
R
L
NE
PL
IE
LT
TQ
-------
Q
A
ML
Q
Q
AV
V
A
GERV
F
E
L
M
DG
P
R
QQ
-----
Y
GNDE
R
PLQ
S
GT
-
-
I
E
VD
NV
S
F
A
Y
-
RD
D
N
LV
LKNINL
S
V
P
S
R
NF
VALVG
H
TGSGKSTLASL
L
M
G
YY
P
L
T
EGEIR
L
DG
R
PL
SS
L
S
H
S
A
LR
QG
VAMV
Q
Q
D
P
V
VL
ADT
FLA
N
VT
LG
-
-RDI
SEER
VW
Q
A
LE
T
V
QLA
E
L
A
RS
M
SD
G
I
Y
T
P
LGE
Q
G
N
N
LS
V
GQKQ
LL
A
L
AR
V
L
V
ETPQ
ILILDEAT
AS
ID
SG
TE
Q
AIQHAL
AAVR
E
H
T
T
L
V
VIAHRLSTI
V
DAD
T
I
L
VL
HR
G
Q
A
VE
Q
GTH
QQ
LL
AAQ
G
R
Y
W
QMYQ
L
Q
LA
GEELAASVR
E
EESLSA
fig|749545.3.peg.2225
Escherichia coli MS 182-1
MRSFSQLW
P
T
LK
RL
LAYGSP
W
--------
-
R
KPL
G
I
A
V
LMM
WV
A
AAA-
--
E
V
SG
P
LLISYFI
D
N
MVAKNN
L
PLK
M
V
A
G
LA
AA
Y
VGL
QL
FAAG
L
----
---
-
--H
Y
AQ
S
L
L
FNR
A
AVG
VV
QQ
LR
T
D
VMDAAL
RQP
L
S
E
FD
T
Q
P
V
G
Q
V
ISR
V
TND
T
E
VIRDLYV
T
VV
A-------
TV
L
R
SA
ALV
G
A
---
M
L
V
A
MF
SL
D
W
RM
---
A
L
V
A
I
M
I
F
PVV
LV
VMVIYQ
R
YSTP
IV
R
RVR
A
YLA
D
I
ND
----
G
FNE
I
IN
G
MSV
I
QQ
F
R
-----------
QQA
R
FGERMGEASRSHYMAR
MQ
TL
R
L
D
G
F
LL
R
P
L
L
S
L
FS
SL
I
L
CG
LL
M
L
F
G
F
S
---
A
S
G
TIE
V
G
V
L
Y
A
F
I
SYLG
R
L
NE
PL
IE
LT
TQ
-------
Q
A
ML
Q
Q
AV
V
A
GERV
F
E
L
M
DG
P
R
QQ
-----
Y
GNDE
R
PLQ
S
GT
-
-
I
E
VD
NV
S
F
A
Y
-
RD
D
N
LV
LKNINL
S
V
P
S
R
NF
VALVG
H
TGSGKSTLASL
L
M
G
YY
P
L
T
EGEIR
L
DG
R
PL
SS
L
S
H
S
A
LR
QG
VAMV
Q
Q
D
P
V
VL
ADT
FLA
N
VT
LG
-
-RDI
SEER
VW
Q
A
LE
T
V
QLA
E
L
A
RS
M
SD
G
I
Y
T
P
LGE
Q
G
N
N
LS
V
GQKQ
LL
A
L
AR
V
L
V
ETPQ
ILILDEAT
AS
ID
SG
TE
Q
AIQHAL
AAVR
E
H
T
T
L
V
VIAHRLSTI
V
DAD
T
I
L
VL
HR
G
Q
A
VE
Q
GTH
QQ
LL
AAQ
G
R
Y
W
QMYQ
L
Q
LA
GEELAASVR
E
EESLSA
fig|749532.3.peg.4727
Escherichia coli MS 78-1
MRSFSQLW
P
T
LK
RL
LAYGSP
W
--------
-
R
KPL
G
I
A
V
LMM
WV
A
AAA-
--
E
V
SG
P
LLISYFI
D
N
MVAKNN
L
PLK
M
V
A
G
LA
AA
Y
VGL
QL
FAAG
L
----
---
-
--H
Y
AQ
S
L
L
FNR
A
AVG
VV
QQ
LR
T
D
VMDAAL
RQP
L
S
E
FD
T
Q
P
V
G
Q
V
ISR
V
TND
T
E
VIRDLYV
T
VV
A-------
TV
L
R
SA
ALV
G
A
---
M
L
V
A
MF
SL
D
W
RM
---
A
L
V
A
I
M
I
F
PVV
LV
VMVIYQ
R
YSTP
IV
R
RVR
A
YLA
D
I
ND
----
G
FNE
I
IN
G
MSV
I
QQ
F
R
-----------
QQA
R
FGERMGEASRSHYMAR
MQ
TL
R
L
D
G
F
LL
R
P
L
L
S
L
FS
SL
I
L
CG
LL
M
L
F
G
F
S
---
A
S
G
TIE
V
G
V
L
Y
A
F
I
SYLG
R
L
NE
PL
IE
LT
TQ
-------
Q
A
ML
Q
Q
AV
V
A
GERV
F
E
L
M
DG
P
R
QQ
-----
Y
GNDE
R
PLQ
S
GT
-
-
I
E
VD
NV
S
F
A
Y
-
RD
D
N
LV
LKNINL
S
V
P
S
R
NF
VALVG
H
TGSGKSTLASL
L
M
G
YY
P
L
T
EGEIR
L
DG
R
PL
SS
L
S
H
S
A
LR
QG
VAMV
Q
Q
D
P
V
VL
ADT
FLA
N
VT
LG
-
-RDI
SEER
VW
Q
A
LE
T
V
QLA
E
L
A
RS
M
SD
G
I
Y
T
P
LGE
Q
G
N
N
LS
V
GQKQ
LL
A
L
AR
V
L
V
ETPQ
ILILDEAT
AS
ID
SG
TE
Q
AIQHAL
AAVR
E
H
T
T
L
V
VIAHRLSTI
V
DAD
T
I
L
VL
HR
G
Q
A
VE
Q
GTH
QQ
LL
AAQ
G
R
Y
W
QMYQ
L
Q
LA
GEELAASVR
E
EESLSA
fig|409438.11.peg.601
Escherichia coli SE11
MRSFSQLW
P
T
LK
RL
LAYGSP
W
--------
-
R
KPL
G
I
A
V
LMM
WV
A
AAA-
--
E
V
SG
P
LLISYFI
D
N
MVAKNN
L
PLK
M
V
A
G
LA
AA
Y
VGL
QL
FAAG
L
----
---
-
--H
Y
AQ
S
L
L
FNR
A
AVG
VV
QQ
LR
T
D
VMDAAL
RQP
L
S
E
FD
T
Q
P
V
G
Q
V
ISR
V
TND
T
E
VIRDLYV
T
VV
A-------
TV
L
R
SA
ALV
G
A
---
M
L
V
A
MF
SL
D
W
RM
---
A
L
V
A
I
M
I
F
PVV
LV
VMVIYQ
R
YSTP
IV
R
RVR
A
YLA
D
I
ND
----
G
FNE
I
IN
G
MSV
I
QQ
F
R
-----------
QQA
R
FGERMGEASRSHYMAR
MQ
TL
R
L
D
G
F
LL
R
P
L
L
S
L
FS
SL
I
L
CG
LL
M
L
F
G
F
S
---
A
S
G
TIE
V
G
V
L
Y
A
F
I
SYLG
R
L
NE
PL
IE
LT
TQ
-------
Q
A
ML
Q
Q
AV
V
A
GERV
F
E
L
M
DG
P
R
QQ
-----
Y
GNDE
R
PLQ
S
GT
-
-
I
E
VD
NV
S
F
A
Y
-
RD
D
N
LV
LKNINL
S
V
P
S
R
NF
VALVG
H
TGSGKSTLASL
L
M
G
YY
P
L
T
EGEIR
L
DG
R
PL
SS
L
S
H
S
A
LR
QG
VAMV
Q
Q
D
P
V
VL
ADT
FLA
N
VT
LG
-
-RDI
SEER
VW
Q
A
LE
T
V
QLA
E
L
A
RS
M
SD
G
I
Y
T
P
LGE
Q
G
N
N
LS
V
GQKQ
LL
A
L
AR
V
L
V
ETPQ
ILILDEAT
AS
ID
SG
TE
Q
AIQHAL
AAVR
E
H
T
T
L
V
VIAHRLSTI
V
DAD
T
I
L
VL
HR
G
Q
A
VE
Q
GTH
QQ
LL
AAQ
G
R
Y
W
QMYQ
L
Q
LA
GEELAASVR
E
EESLSA
fig|749547.3.peg.2458
Escherichia coli MS 187-1
MRSFSQLW
P
T
LK
RL
LAYGSP
W
--------
-
R
KPL
G
I
A
V
LMM
WV
A
AAA-
--
E
V
SG
P
LLISYFI
D
N
MVAKNN
L
PLK
M
V
A
G
LA
AA
Y
VGL
QL
FAAG
L
----
---
-
--H
Y
AQ
S
L
L
FNR
A
AVG
VV
QQ
LR
T
D
VMDAAL
RQP
L
S
E
FD
T
Q
P
V
G
Q
V
ISR
V
TND
T
E
VIRDLYV
T
VV
A-------
TV
L
R
SA
ALV
G
A
---
M
L
V
A
MF
SL
D
W
RM
---
A
L
V
A
I
M
I
F
PVV
LV
VMVIYQ
R
YSTP
IV
R
RVR
A
YLA
D
I
ND
----
G
FNE
I
IN
G
MSV
I
QQ
F
R
-----------
QQA
R
FGERMGEASRSHYMAR
MQ
TL
R
L
D
G
F
LL
R
P
L
L
S
L
FS
SL
I
L
CG
LL
M
L
F
G
F
S
---
A
S
G
TIE
V
G
V
L
Y
A
F
I
SYLG
R
L
NE
PL
IE
LT
TQ
-------
Q
A
ML
Q
Q
AV
V
A
GERV
F
E
L
M
DG
P
R
QQ
-----
Y
GNDD
R
PLQ
S
G
A
-
-
I
E
VD
NV
S
F
A
Y
-
RD
D
N
LV
LKNINL
S
V
P
S
R
NF
VALVG
H
TGSGKSTLASL
L
M
G
YY
P
L
T
EGEIR
L
DG
R
PL
SS
L
S
H
S
A
LR
QG
VAMV
Q
Q
D
P
V
VL
ADT
FLA
N
VT
LG
-
-RDI
SEER
VW
Q
A
LE
T
V
QLA
E
L
A
RS
M
SD
G
I
Y
T
P
LGE
Q
G
N
N
LS
V
GQKQ
LL
A
L
AR
V
L
V
ETPQ
ILILDEAT
AS
ID
SG
TE
Q
AIQHAL
AAVR
E
H
T
T
L
V
VIAHRLSTI
V
DAD
T
I
L
VL
HR
G
Q
A
VE
Q
GTH
QQ
LL
AAQ
G
R
Y
W
QMYQ
L
Q
LA
GEELAASVR
E
EESLSA
fig|216592.3.peg.511
Escherichia coli 042
MRSFSQLW
P
T
LK
RL
LAYGSP
W
--------
-
R
KPL
G
I
A
V
LMM
WV
A
AAA-
--
E
V
SG
P
LLISYFI
D
N
MVAKNN
L
PLK
V
V
A
G
LA
AA
Y
VGL
QL
FAAG
L
----
---
-
--H
Y
AQ
S
L
L
FNR
A
AVG
VV
QQ
LR
T
D
VMDAAL
RQP
L
S
E
FD
T
Q
P
V
G
Q
V
ISR
V
TND
T
E
VIRDLYV
T
VV
A-------
TV
L
R
SA
ALV
G
A
---
M
L
V
A
MF
SL
D
W
RM
---
A
L
V
A
I
M
I
F
PVV
LV
VMVIYQ
R
YSTP
IV
R
RVR
A
YLA
D
I
ND
----
G
FNE
I
IN
G
MSV
I
QQ
F
R
-----------
QQA
R
FGERMGEASRSHYMAR
MQ
TL
R
L
D
G
F
LL
R
P
L
L
S
L
FS
SL
I
L
CG
LL
I
L
F
G
F
S
---
A
S
G
TIE
V
G
V
L
Y
A
F
I
SYLG
R
L
NE
PL
IE
LT
TQ
-------
Q
A
ML
Q
Q
AV
V
A
GERV
F
E
L
M
DG
P
R
QQ
-----
Y
GNDD
R
PLQ
S
GT
-
-
I
E
VD
NV
S
F
A
Y
-
RD
D
N
LV
LKNINL
S
V
P
S
R
NF
VALVG
H
TGSGKSTLASL
L
M
G
YY
P
L
T
EGEIR
L
DG
R
PL
SS
L
S
H
S
A
LR
QG
VAMV
Q
Q
D
P
V
VL
ADT
FLA
N
VT
LG
-
-RDI
SEER
VW
Q
A
LE
T
V
QLA
E
L
A
RS
M
SD
G
I
Y
T
P
LGE
Q
G
N
N
LS
V
GQKQ
LL
A
L
AR
V
L
V
ETPQ
ILILDEAT
AS
ID
SG
TE
Q
AIQHAL
AAVR
E
H
T
T
L
V
VIAHRLSTI
V
DAD
T
I
L
VL
HR
G
Q
A
VE
Q
GTH
QQ
LL
AAQ
G
R
Y
W
QMYQ
L
Q
LA
GEELAASVR
E
EESLSA
fig|656437.3.peg.534
Escherichia coli TA143
MRSFSQLW
P
T
LK
RL
LAYGSP
W
--------
-
R
KPL
G
I
A
V
LMM
WV
A
AAA-
--
E
V
SG
P
LLISYFI
D
N
MVAKNN
L
PLK
V
V
A
G
LA
AA
Y
VGL
QL
FAAG
L
----
---
-
--H
Y
AQ
S
L
L
FNR
A
AVG
VV
QQ
LR
T
D
VMDAAL
RQP
L
S
E
FD
T
Q
P
V
G
Q
V
ISR
V
TND
T
E
VIRDLYV
T
VV
A-------
TV
L
R
SA
ALV
G
A
---
M
L
V
A
MF
SL
D
W
RM
---
A
L
V
A
I
M
I
F
PVV
LV
VMVIYQ
R
YSTP
IV
R
RVR
A
YLA
D
I
ND
----
G
FNE
I
IN
G
MSV
I
QQ
F
R
-----------
QQA
R
FGERMGEASRSHYMAR
MQ
TL
R
L
D
G
F
LL
R
P
L
L
S
L
FS
SL
I
L
CG
LL
I
L
F
G
F
S
---
A
S
G
TIE
V
G
V
L
Y
A
F
I
SYLG
R
L
NE
PL
IE
LT
TQ
-------
Q
A
ML
Q
Q
AV
V
A
GERV
F
E
L
M
DG
P
R
QQ
-----
Y
GNDD
R
PLQ
S
GT
-
-
I
E
VD
NV
S
F
A
Y
-
RD
D
N
LV
LKNINL
S
V
P
S
R
NF
VALVG
H
TGSGKSTLASL
L
M
G
YY
P
L
T
EGEIR
L
DG
R
PL
SS
L
S
H
S
A
LR
QG
VAMV
Q
Q
D
P
V
VL
ADT
FLA
N
VT
LG
-
-RDI
SEER
VW
Q
A
LE
T
V
QLA
E
L
A
RS
M
SD
G
I
Y
T
P
LGE
Q
G
N
N
LS
V
GQKQ
LL
A
L
AR
V
L
V
ETPQ
ILILDEAT
AS
ID
SG
TE
Q
AIQHAL
AAVR
E
H
T
T
L
V
VIAHRLSTI
V
DAD
T
I
L
VL
HR
G
Q
A
VE
Q
GTH
QQ
LL
AAQ
G
R
Y
W
QMYQ
L
Q
LA
GEELAASVR
E
EESLSA
fig|550676.3.peg.1246
Escherichia coli B185
MRSFSQLW
P
T
LK
RL
LAYGSP
W
--------
-
R
KPL
G
I
A
V
LMM
WV
A
AAA-
--
E
V
SG
P
LLISYFI
D
N
MVAKNN
L
PLK
V
V
A
G
LA
AA
Y
VGL
QL
FAAG
L
----
---
-
--H
Y
AQ
S
L
L
FNR
A
AVG
VV
QQ
LR
T
D
VMDAAL
RQP
L
S
E
FD
T
Q
P
V
G
Q
V
ISR
V
TND
T
E
VIRDLYV
T
VV
A-------
TV
L
R
SA
ALV
G
A
---
M
L
V
A
MF
SL
D
W
RM
---
A
L
V
A
I
M
I
F
PVV
LV
VMVIYQ
R
YSTP
IV
R
RVR
A
YLA
D
I
ND
----
G
FNE
I
IN
G
MSV
I
QQ
F
R
-----------
QQA
R
FGERMGEASRSHYMAR
MQ
TL
R
L
D
G
F
LL
R
P
L
L
S
L
FS
SL
I
L
CG
LL
M
L
F
G
F
S
---
A
S
G
TIE
V
G
V
L
Y
A
F
I
SYLG
R
L
NE
PL
IE
LT
TQ
-------
Q
A
ML
Q
Q
AV
V
A
GERV
F
E
L
M
DG
P
R
QQ
-----
Y
GNDD
R
PLQ
S
GT
-
-
I
E
VD
NV
S
F
A
Y
-
RD
N
N
LV
LKNINL
S
V
P
S
R
NF
VALVG
H
TGSGKSTLASL
L
M
G
YY
P
L
T
EGEIR
L
DG
R
PL
SS
L
S
H
S
A
LR
QG
VAMV
Q
Q
D
P
V
VL
ADT
FLA
N
VT
LG
-
-RDI
SEER
VW
Q
A
LE
T
V
QLA
E
L
A
RS
M
SD
G
I
Y
T
P
LGE
Q
G
N
N
LS
V
GQKQ
LL
A
L
AR
V
L
V
ETPQ
ILILDEAT
AS
ID
SG
TE
Q
AIQHAL
AAVR
E
H
T
T
L
V
VIAHRLSTI
V
DAD
T
I
L
VL
HR
G
Q
A
VE
Q
GTH
QQ
LL
AAQ
G
R
Y
W
QMYQ
L
Q
LA
GEELAASVR
E
EESLSA
fig|656419.3.peg.656
Escherichia coli M718
MRSFSQLW
P
T
LK
RL
LAYGSP
W
--------
-
R
KPL
G
I
A
V
LMM
WV
A
AAA-
--
E
V
SG
P
LLISYFI
D
N
MVAKNN
L
PLK
V
V
A
G
LA
AA
Y
VGL
QL
FAAG
L
----
---
-
--H
Y
AQ
S
L
L
FNR
A
AVG
VV
QQ
LR
T
D
VMDAAL
RQP
L
S
E
FD
T
Q
P
V
G
Q
V
ISR
V
TND
T
E
VIRDLYV
T
VV
A-------
TV
L
R
SA
ALV
G
A
---
M
L
V
A
MF
SL
D
W
RM
---
A
L
V
A
I
M
I
F
PVV
LV
VMVIYQ
R
YSTP
IV
R
RVR
A
YLA
D
I
ND
----
G
FNE
I
IN
G
MSV
I
QQ
F
R
-----------
QQA
R
FGERMGEASRSHYMAR
MQ
TL
R
L
D
G
F
LL
R
P
L
L
S
L
FS
SL
I
L
CG
LL
M
L
F
G
F
S
---
A
S
G
TIE
V
G
V
L
Y
A
F
I
SYLG
R
L
NE
PL
IE
LT
TQ
-------
Q
A
ML
Q
Q
AV
V
A
GERV
F
E
L
M
DG
P
R
QQ
-----
Y
GNDD
R
PLQ
S
GT
-
-
I
E
VD
NV
S
F
A
Y
-
RD
N
N
LV
LKNINL
S
V
P
S
R
NF
VALVG
H
TGSGKSTLASL
L
M
G
YY
P
L
T
EGEIR
L
DG
R
PL
SS
L
S
H
S
A
LR
QG
VAMV
Q
Q
D
P
V
VL
ADT
FLA
N
VT
LG
-
-RDI
SEER
VW
Q
A
LE
T
V
QLA
E
L
A
RS
M
SD
G
I
Y
T
P
LGE
Q
G
N
N
LS
V
GQKQ
LL
A
L
AR
V
L
V
ETPQ
ILILDEAT
AS
ID
SG
TE
Q
AIQHAL
AAVR
E
H
T
T
L
V
VIAHRLSTI
V
DAD
T
I
L
VL
HR
G
Q
A
VE
Q
GTH
QQ
LL
AAQ
G
R
Y
W
QMYQ
L
Q
LA
GEELAASVR
E
EESLSA
fig|749537.3.peg.1858
Escherichia coli MS 115-1
MRSFSQLW
P
T
LK
RL
LAYGSP
W
--------
-
R
KPL
G
I
A
V
LMM
WV
A
AAA-
--
E
V
SG
P
LLISYFI
D
N
MVAKNN
L
PLK
V
V
A
G
LA
AA
Y
VGL
QL
FAAG
L
----
---
-
--H
Y
AQ
S
L
L
FNR
A
AVG
VV
QQ
LR
T
D
VMDAAL
RQP
L
S
E
FD
T
Q
P
V
G
Q
V
ISR
V
TND
T
E
VIRDLYV
T
VV
A-------
TV
L
R
SA
ALV
G
A
---
M
L
V
A
MF
SL
D
W
RM
---
A
L
V
A
I
M
I
F
PVV
LV
VMVIYQ
R
YSTP
IV
R
RVR
A
YLA
D
I
ND
----
G
FNE
I
IN
G
MSV
I
QQ
F
R
-----------
QQA
R
FGERMGEASRSHYMAR
MQ
TL
R
L
D
G
F
LL
R
P
L
L
S
L
FS
SL
I
L
CG
LL
M
L
F
G
F
S
---
A
S
G
TIE
V
G
V
L
Y
A
F
I
SYLG
R
L
NE
PL
IE
LT
TQ
-------
Q
A
ML
Q
Q
AV
V
A
GERV
F
E
L
M
DG
P
R
QQ
-----
Y
GNDD
R
PLQ
S
GT
-
-
I
E
VD
NV
S
F
A
Y
-
RD
N
N
LV
LKNINL
S
V
P
S
R
NF
VALVG
H
TGSGKSTLASL
L
M
G
YY
P
L
T
EGEIR
L
DG
R
PL
SS
L
S
H
S
A
LR
QG
VAMV
Q
Q
D
P
V
VL
ADT
FLA
N
VT
LG
-
-RDI
SEER
VW
Q
A
LE
T
V
QLA
E
L
A
RS
M
SD
G
I
Y
T
P
LGE
Q
G
N
N
LS
V
GQKQ
LL
A
L
AR
V
L
V
ETPQ
ILILDEAT
AS
ID
SG
TE
Q
AIQHAL
AAVR
E
H
T
T
L
V
VIAHRLSTI
V
DAD
T
I
L
VL
HR
G
Q
A
VE
Q
GTH
QQ
LL
AAQ
G
R
Y
W
QMYQ
L
Q
LA
GEELAASVR
E
EESLSA
fig|670897.3.peg.270
Escherichia coli 2362-75
MRSFSQLW
P
T
LK
RL
LAYGSP
W
--------
-
R
KPL
G
I
A
V
LMM
WV
A
AAA-
--
E
V
SG
P
LLISYFI
D
N
MVAKNN
L
PLK
V
V
A
G
LA
AA
Y
VGL
QL
FAAG
L
----
---
-
--H
Y
AQ
S
L
L
FNR
A
AVG
VV
QQ
LR
T
D
VMDAAL
RQP
L
S
E
FD
T
Q
P
V
G
Q
V
ISR
V
TND
T
E
VIRDLYV
T
VV
A-------
TV
L
R
SA
ALV
G
A
---
M
L
V
A
MF
SL
D
W
RM
---
A
L
V
A
I
M
I
F
PVV
LV
VMVIYQ
R
YSTP
IV
R
RVR
A
YLA
D
I
ND
----
G
FNE
I
IN
G
MSV
I
QQ
F
R
-----------
QQA
R
FGERMGEASRSHYMAR
MQ
TL
R
L
D
G
F
LL
R
P
L
L
S
L
FS
SL
I
L
CG
LL
M
L
F
G
F
S
---
A
S
G
TIE
V
G
V
L
Y
A
F
I
SYLG
R
L
NE
PL
IE
LT
TQ
-------
Q
A
ML
Q
Q
AV
V
A
GERV
F
E
L
M
DG
P
R
QQ
-----
Y
GNDD
R
PLQ
S
GT
-
-
I
D
VD
NV
S
F
A
Y
-
RD
D
N
LV
LKNINL
S
V
P
S
R
NF
VALVG
H
TGSGKSTLASL
L
M
G
YY
P
L
T
EGEIR
L
DG
R
PL
ST
L
S
H
S
A
LR
QG
VAMV
Q
Q
D
P
V
VL
ADT
FLA
N
VT
LG
-
-RDI
SEER
VW
Q
A
LE
T
V
QLA
E
L
A
RS
M
SD
G
I
Y
T
P
LGE
Q
G
N
N
LS
V
GQKQ
LL
A
L
AR
V
L
V
ETPQ
ILILDEAT
AS
ID
SG
TE
Q
AIQHAL
AAVR
E
H
T
T
L
V
VIAHRLSTI
V
DAD
T
I
L
VL
HR
G
Q
A
VE
Q
GTH
QQ
LL
AAQ
G
R
Y
W
QMYQ
L
Q
LA
GEELAASVR
E
EESLSA
fig|585034.4.peg.448
Escherichia coli IAI1
MRSFSQLW
P
T
LK
RL
LAYGSP
W
--------
-
R
KPL
G
I
A
V
LMM
WV
A
AAA-
--
E
V
SG
P
LLISYFI
D
N
MVAKNN
L
PLK
M
V
A
G
LA
AA
Y
VGL
QL
FAAG
L
----
---
-
--H
Y
AQ
S
L
L
FNR
A
AVG
VV
QQ
LR
T
D
VMDAAL
RQP
L
S
E
FD
T
Q
P
V
G
Q
V
ISR
V
TND
T
E
VIRDLYV
T
VV
A-------
TV
L
R
ST
ALV
G
A
---
M
L
V
A
MF
SL
D
W
RM
---
A
L
V
A
I
M
I
F
PVV
LV
VMVIYQ
R
YSTP
IV
R
RVR
A
YLA
D
I
ND
----
G
FNE
I
IN
G
MSV
I
QQ
F
R
-----------
QQA
R
FGERMGEASRSHYMAR
MQ
TL
R
L
D
G
F
LL
R
P
L
L
S
L
FS
SL
I
L
CG
LL
M
L
F
G
F
S
---
A
S
G
TIE
V
G
V
L
Y
A
F
I
SYLG
R
L
NE
PL
IE
LT
TQ
-------
Q
A
ML
Q
Q
AV
V
A
GERV
F
E
L
M
DG
P
R
QQ
-----
Y
GNDD
Y
PLQ
S
GT
-
-
I
E
VD
NV
S
F
A
Y
-
RD
D
N
LV
LKNINL
S
V
P
S
R
NF
VALVG
H
TGSGKSTLASL
L
M
G
YY
P
L
T
EGEIR
L
DG
R
PL
SS
L
S
H
S
A
LR
QG
VAMV
Q
Q
D
P
V
VL
ADT
FLA
N
VT
LG
-
-RDI
SEER
VW
Q
A
LE
T
V
QLA
E
L
A
RS
M
SD
G
I
Y
T
P
LGE
Q
G
N
N
LS
V
GQKQ
LL
A
L
AR
V
L
V
ETPQ
ILILDEAT
AS
ID
SG
TE
Q
AIQHAL
AAVR
E
H
T
T
L
V
VIAHRLSTI
V
DAD
T
I
L
VL
HR
G
Q
A
VE
Q
GTH
QQ
LL
AAQ
G
R
Y
W
QMYQ
L
Q
LA
GEELAASVR
E
EESLSA
fig|585034.5.peg.447
Escherichia coli IAI1
MRSFSQLW
P
T
LK
RL
LAYGSP
W
--------
-
R
KPL
G
I
A
V
LMM
WV
A
AAA-
--
E
V
SG
P
LLISYFI
D
N
MVAKNN
L
PLK
M
V
A
G
LA
AA
Y
VGL
QL
FAAG
L
----
---
-
--H
Y
AQ
S
L
L
FNR
A
AVG
VV
QQ
LR
T
D
VMDAAL
RQP
L
S
E
FD
T
Q
P
V
G
Q
V
ISR
V
TND
T
E
VIRDLYV
T
VV
A-------
TV
L
R
ST
ALV
G
A
---
M
L
V
A
MF
SL
D
W
RM
---
A
L
V
A
I
M
I
F
PVV
LV
VMVIYQ
R
YSTP
IV
R
RVR
A
YLA
D
I
ND
----
G
FNE
I
IN
G
MSV
I
QQ
F
R
-----------
QQA
R
FGERMGEASRSHYMAR
MQ
TL
R
L
D
G
F
LL
R
P
L
L
S
L
FS
SL
I
L
CG
LL
M
L
F
G
F
S
---
A
S
G
TIE
V
G
V
L
Y
A
F
I
SYLG
R
L
NE
PL
IE
LT
TQ
-------
Q
A
ML
Q
Q
AV
V
A
GERV
F
E
L
M
DG
P
R
QQ
-----
Y
GNDD
Y
PLQ
S
GT
-
-
I
E
VD
NV
S
F
A
Y
-
RD
D
N
LV
LKNINL
S
V
P
S
R
NF
VALVG
H
TGSGKSTLASL
L
M
G
YY
P
L
T
EGEIR
L
DG
R
PL
SS
L
S
H
S
A
LR
QG
VAMV
Q
Q
D
P
V
VL
ADT
FLA
N
VT
LG
-
-RDI
SEER
VW
Q
A
LE
T
V
QLA
E
L
A
RS
M
SD
G
I
Y
T
P
LGE
Q
G
N
N
LS
V
GQKQ
LL
A
L
AR
V
L
V
ETPQ
ILILDEAT
AS
ID
SG
TE
Q
AIQHAL
AAVR
E
H
T
T
L
V
VIAHRLSTI
V
DAD
T
I
L
VL
HR
G
Q
A
VE
Q
GTH
QQ
LL
AAQ
G
R
Y
W
QMYQ
L
Q
LA
GEELAASVR
E
EESLSA
fig|595495.4.peg.420
Escherichia coli KO11
MRSFSQLW
P
T
LK
RL
LAYGSP
W
--------
-
R
KPL
G
I
A
V
LMM
WV
A
AAA-
--
E
V
SG
P
LLISYFI
D
N
MVAKNN
L
PLK
M
V
A
G
LA
AA
Y
VGL
QL
FAAG
L
----
---
-
--H
Y
AQ
S
L
L
FNR
A
AVG
VV
QQ
LR
T
D
VMDAAL
RQP
L
S
E
FD
T
Q
P
V
G
Q
V
ISR
V
TND
T
E
VIRDLYV
T
VV
A-------
TV
L
R
SA
ALV
G
A
---
M
L
V
A
MF
SL
D
W
RM
---
A
L
V
A
I
M
I
F
PVV
LV
VMVIYQ
R
YSTP
IV
R
RVR
A
YLA
D
I
ND
----
G
FNE
I
IN
G
MSV
I
QQ
F
R
-----------
QQA
R
FGERMGEASRSHYMAR
MQ
TL
R
L
D
G
F
LL
R
P
L
L
S
L
FS
SL
I
L
CG
LL
M
L
F
G
F
S
---
A
S
G
TIE
V
G
V
L
Y
A
F
I
SYLG
R
L
NE
PL
IE
LT
TQ
-------
Q
A
ML
Q
Q
AV
V
A
GERV
F
E
L
M
DG
P
R
QQ
-----
Y
GNDE
R
PLQ
S
GT
-
-
I
E
VD
NV
S
F
A
Y
-
RD
D
N
LV
LKNINL
S
M
P
S
R
NF
VALVG
H
TGSGKSTLASL
L
M
G
YY
P
L
T
EGEIR
L
DG
R
PL
SS
L
S
H
S
A
LR
QG
VAMV
Q
Q
D
P
V
VL
ADT
FLA
N
VT
LG
-
-RDI
SEER
VW
Q
A
LE
T
V
QLA
E
L
A
RS
M
SD
G
I
Y
T
P
LGE
Q
G
N
N
LS
V
GQKQ
LL
A
L
AR
V
L
V
ETPQ
ILILDEAT
AS
ID
SG
TE
Q
AIQHAL
AAVR
E
H
T
T
L
V
VIAHRLSTI
V
DAD
T
I
L
VL
HR
G
Q
A
VE
Q
GTH
QQ
LL
AAQ
G
R
Y
W
QMYQ
L
Q
LA
GEELAASVR
E
EESLSA
fig|566546.3.peg.2335
Escherichia coli W
MRSFSQLW
P
T
LK
RL
LAYGSP
W
--------
-
R
KPL
G
I
A
V
LMM
WV
A
AAA-
--
E
V
SG
P
LLISYFI
D
N
MVAKNN
L
PLK
M
V
A
G
LA
AA
Y
VGL
QL
FAAG
L
----
---
-
--H
Y
AQ
S
L
L
FNR
A
AVG
VV
QQ
LR
T
D
VMDAAL
RQP
L
S
E
FD
T
Q
P
V
G
Q
V
ISR
V
TND
T
E
VIRDLYV
T
VV
A-------
TV
L
R
SA
ALV
G
A
---
M
L
V
A
MF
SL
D
W
RM
---
A
L
V
A
I
M
I
F
PVV
LV
VMVIYQ
R
YSTP
IV
R
RVR
A
YLA
D
I
ND
----
G
FNE
I
IN
G
MSV
I
QQ
F
R
-----------
QQA
R
FGERMGEASRSHYMAR
MQ
TL
R
L
D
G
F
LL
R
P
L
L
S
L
FS
SL
I
L
CG
LL
M
L
F
G
F
S
---
A
S
G
TIE
V
G
V
L
Y
A
F
I
SYLG
R
L
NE
PL
IE
LT
TQ
-------
Q
A
ML
Q
Q
AV
V
A
GERV
F
E
L
M
DG
P
R
QQ
-----
Y
GNDE
R
PLQ
S
GT
-
-
I
E
VD
NV
S
F
A
Y
-
RD
D
N
LV
LKNINL
S
M
P
S
R
NF
VALVG
H
TGSGKSTLASL
L
M
G
YY
P
L
T
EGEIR
L
DG
R
PL
SS
L
S
H
S
A
LR
QG
VAMV
Q
Q
D
P
V
VL
ADT
FLA
N
VT
LG
-
-RDI
SEER
VW
Q
A
LE
T
V
QLA
E
L
A
RS
M
SD
G
I
Y
T
P
LGE
Q
G
N
N
LS
V
GQKQ
LL
A
L
AR
V
L
V
ETPQ
ILILDEAT
AS
ID
SG
TE
Q
AIQHAL
AAVR
E
H
T
T
L
V
VIAHRLSTI
V
DAD
T
I
L
VL
HR
G
Q
A
VE
Q
GTH
QQ
LL
AAQ
G
R
Y
W
QMYQ
L
Q
LA
GEELAASVR
E
EESLSA
fig|566546.4.peg.526
Escherichia coli W
MRSFSQLW
P
T
LK
RL
LAYGSP
W
--------
-
R
KPL
G
I
A
V
LMM
WV
A
AAA-
--
E
V
SG
P
LLISYFI
D
N
MVAKNN
L
PLK
M
V
A
G
LA
AA
Y
VGL
QL
FAAG
L
----
---
-
--H
Y
AQ
S
L
L
FNR
A
AVG
VV
QQ
LR
T
D
VMDAAL
RQP
L
S
E
FD
T
Q
P
V
G
Q
V
ISR
V
TND
T
E
VIRDLYV
T
VV
A-------
TV
L
R
SA
ALV
G
A
---
M
L
V
A
MF
SL
D
W
RM
---
A
L
V
A
I
M
I
F
PVV
LV
VMVIYQ
R
YSTP
IV
R
RVR
A
YLA
D
I
ND
----
G
FNE
I
IN
G
MSV
I
QQ
F
R
-----------
QQA
R
FGERMGEASRSHYMAR
MQ
TL
R
L
D
G
F
LL
R
P
L
L
S
L
FS
SL
I
L
CG
LL
M
L
F
G
F
S
---
A
S
G
TIE
V
G
V
L
Y
A
F
I
SYLG
R
L
NE
PL
IE
LT
TQ
-------
Q
A
ML
Q
Q
AV
V
A
GERV
F
E
L
M
DG
P
R
QQ
-----
Y
GNDE
R
PLQ
S
GT
-
-
I
E
VD
NV
S
F
A
Y
-
RD
D
N
LV
LKNINL
S
M
P
S
R
NF
VALVG
H
TGSGKSTLASL
L
M
G
YY
P
L
T
EGEIR
L
DG
R
PL
SS
L
S
H
S
A
LR
QG
VAMV
Q
Q
D
P
V
VL
ADT
FLA
N
VT
LG
-
-RDI
SEER
VW
Q
A
LE
T
V
QLA
E
L
A
RS
M
SD
G
I
Y
T
P
LGE
Q
G
N
N
LS
V
GQKQ
LL
A
L
AR
V
L
V
ETPQ
ILILDEAT
AS
ID
SG
TE
Q
AIQHAL
AAVR
E
H
T
T
L
V
VIAHRLSTI
V
DAD
T
I
L
VL
HR
G
Q
A
VE
Q
GTH
QQ
LL
AAQ
G
R
Y
W
QMYQ
L
Q
LA
GEELAASVR
E
EESLSA
fig|656414.3.peg.643
Escherichia coli H736
MRSFSQLW
P
T
LK
RL
LAYGSP
W
--------
-
R
KPL
G
I
A
V
LMM
WV
A
AAA-
--
E
V
SG
P
LLISYFI
D
N
MVAKNN
L
PLK
V
V
A
G
LA
AA
Y
VGL
QL
FAAG
L
----
---
-
--H
Y
AQ
S
L
L
FNR
A
AVG
VV
QQ
LR
T
D
VMDAAL
RQP
L
S
E
FD
T
Q
P
V
G
Q
V
ISR
V
TND
T
E
VIRDLYV
T
VV
A-------
TV
L
R
SA
ALV
G
A
---
M
L
V
A
MF
SL
D
W
RM
---
A
L
V
A
I
M
I
F
PVV
LV
VMVIYQ
R
YSTP
IV
R
RVR
A
YLA
D
I
ND
----
G
FNE
I
IN
G
MSV
I
QQ
F
R
-----------
QQA
R
FGERMGEASRSHYMAR
MQ
TL
R
L
D
G
F
LL
R
P
L
L
S
L
FS
SL
I
L
CG
LL
M
L
F
G
F
S
---
A
S
G
TIE
V
G
V
L
Y
A
F
I
SYLG
R
L
NE
PL
IE
LT
TQ
-------
Q
A
ML
Q
Q
AV
V
A
GERV
F
E
L
M
DG
P
R
QQ
-----
Y
GNDD
R
PLQ
S
GT
-
-
I
E
VD
NV
S
F
A
Y
-
RD
D
N
LV
LKNINL
S
V
P
S
R
NF
VALVG
H
TGSGKSTLASL
L
M
G
YY
P
L
T
EGEIR
L
DG
R
PL
SS
L
S
H
S
A
LR
QG
VAMV
Q
Q
D
P
V
VL
ADT
FLA
N
VT
LG
-
-RDI
SEER
VW
Q
A
LE
T
V
QLA
E
L
A
RS
M
SD
G
I
Y
T
P
LGE
Q
G
N
N
LS
V
GQKQ
LL
A
L
AR
V
L
V
ETPQ
ILILDEAT
AS
ID
SG
TE
Q
AIQHAL
AAVR
E
H
T
T
L
V
VIAHRLSTI
V
DAD
T
I
Q
VL
HR
G
Q
A
VE
Q
GTH
QQ
LL
AAQ
G
R
Y
W
QMYQ
L
Q
LA
GEELAASVR
E
EESLSA
fig|749540.3.peg.3767
Escherichia coli MS 146-1
MRSFSQLW
P
T
LK
RL
LAYGSP
W
--------
-
R
KPL
G
I
A
V
LMM
WV
A
AAA-
--
E
V
SG
P
LLISYFI
D
N
MVAKNN
L
PLK
V
V
A
G
LA
AA
Y
VGL
QL
FAAG
L
----
---
-
--H
Y
AQ
S
L
L
FNR
A
AVG
VV
QQ
LR
T
D
VMDAAL
RQP
L
S
E
FD
T
Q
P
V
G
Q
V
ISR
V
TND
T
E
VIRDLYV
T
VV
A-------
TV
L
R
SA
ALV
G
A
---
M
L
V
A
MF
SL
D
W
RM
---
A
L
V
A
I
M
I
F
PVV
LV
VMVIYQ
R
YSTP
IV
R
RVR
A
YLA
D
I
ND
----
G
FNE
I
IN
G
MSV
I
QQ
F
R
-----------
QQA
R
FGERMGEASRSHYMAR
MQ
TL
R
L
D
G
F
LL
R
P
L
L
S
L
FS
SL
I
L
CG
LL
M
L
F
G
F
S
---
A
S
G
TIE
V
G
V
L
Y
A
F
I
SYLG
R
L
NE
PL
IE
LT
TQ
-------
Q
A
ML
Q
Q
AV
V
A
GERV
F
E
L
M
DG
P
R
QQ
-----
Y
GNDD
R
PLQ
S
GT
-
-
I
E
VD
NV
S
F
A
Y
-
RD
D
N
LV
LKNINL
S
V
P
S
R
NF
VALVG
H
TGSGKSTLASL
L
M
G
YY
P
L
T
EGEIR
L
DG
R
PL
SS
L
S
H
S
A
LR
QG
VAMV
Q
Q
D
P
V
VL
ADT
FLA
N
VT
LG
-
-RDI
SEER
VW
Q
A
LE
T
V
QLA
E
L
A
RS
M
SD
G
I
Y
T
P
LGE
Q
G
N
N
LS
V
GQKQ
LL
A
L
AR
V
L
V
ETPQ
ILILDEAT
AS
ID
SG
TE
Q
AIQHAL
AAVR
E
H
T
T
L
V
VIAHRLSTI
V
DAD
T
I
Q
VL
HR
G
Q
A
VE
Q
GTH
QQ
LL
AAQ
G
R
Y
W
QMYQ
L
Q
LA
GEELAASVR
E
EESLSA
fig|585057.4.peg.243
Escherichia coli IAI39
MRSFSQLW
P
T
LK
RL
LAYGSP
W
--------
-
R
KPL
G
I
A
V
LMM
WV
A
AAA-
--
E
V
SG
P
LLISYFI
D
N
MVANNN
L
PLK
V
V
A
G
LA
AA
Y
VGL
QL
FAAG
L
----
---
-
--H
Y
AQ
S
L
L
FNR
A
AVG
VV
QQ
LR
T
D
VMDAAL
RQP
L
S
E
FD
T
Q
P
V
G
Q
V
ISR
V
TND
T
E
VIRDLYV
T
VV
A-------
TV
L
R
SA
ALV
G
A
---
M
L
V
A
MF
SL
D
W
RM
---
A
L
V
A
I
M
I
F
PVV
LV
VMVIYQ
R
YSTP
IV
R
RVR
A
YLA
D
I
ND
----
G
FNE
I
IN
G
MSV
I
QQ
F
R
-----------
QQA
R
FGERMGEASRSHYMAR
MQ
TL
R
L
D
G
F
LL
R
P
L
L
S
L
FS
SL
I
L
CG
LL
M
L
F
G
F
S
---
A
S
G
TIE
V
G
V
L
Y
A
F
I
SYLG
R
L
NE
PL
IE
LT
TQ
-------
Q
A
ML
Q
Q
AV
V
A
GERV
F
E
L
M
DG
P
R
QQ
-----
Y
GNDD
R
PLQ
S
GT
-
-
I
E
VD
NV
S
F
A
Y
-
RD
D
N
M
V
LKNINL
S
V
P
S
R
NF
VALVG
H
TGSGKSTLASL
L
M
G
YY
P
L
T
EGEIR
L
DG
R
PL
SS
L
S
H
S
A
LR
QG
VAMV
Q
Q
D
P
V
VL
ADT
FLA
N
VT
LG
-
-RDI
SEER
VW
Q
A
LE
T
V
QLA
E
L
A
RS
M
SD
G
I
Y
T
P
LGE
Q
G
N
N
LS
V
GQKQ
LL
A
L
AR
V
L
V
ETPQ
ILILDEAT
AS
ID
SG
TE
Q
AIQHAL
AAVR
E
H
T
T
L
V
VIAHRLSTI
V
DAD
T
I
L
VL
HR
G
Q
A
VE
Q
GTH
QQ
LL
AAQ
G
R
Y
W
QMYQ
L
Q
LA
GEELAASVR
E
EESLSA
fig|585057.6.peg.242
Escherichia coli IAI39
MRSFSQLW
P
T
LK
RL
LAYGSP
W
--------
-
R
KPL
G
I
A
V
LMM
WV
A
AAA-
--
E
V
SG
P
LLISYFI
D
N
MVANNN
L
PLK
V
V
A
G
LA
AA
Y
VGL
QL
FAAG
L
----
---
-
--H
Y
AQ
S
L
L
FNR
A
AVG
VV
QQ
LR
T
D
VMDAAL
RQP
L
S
E
FD
T
Q
P
V
G
Q
V
ISR
V
TND
T
E
VIRDLYV
T
VV
A-------
TV
L
R
SA
ALV
G
A
---
M
L
V
A
MF
SL
D
W
RM
---
A
L
V
A
I
M
I
F
PVV
LV
VMVIYQ
R
YSTP
IV
R
RVR
A
YLA
D
I
ND
----
G
FNE
I
IN
G
MSV
I
QQ
F
R
-----------
QQA
R
FGERMGEASRSHYMAR
MQ
TL
R
L
D
G
F
LL
R
P
L
L
S
L
FS
SL
I
L
CG
LL
M
L
F
G
F
S
---
A
S
G
TIE
V
G
V
L
Y
A
F
I
SYLG
R
L
NE
PL
IE
LT
TQ
-------
Q
A
ML
Q
Q
AV
V
A
GERV
F
E
L
M
DG
P
R
QQ
-----
Y
GNDD
R
PLQ
S
GT
-
-
I
E
VD
NV
S
F
A
Y
-
RD
D
N
M
V
LKNINL
S
V
P
S
R
NF
VALVG
H
TGSGKSTLASL
L
M
G
YY
P
L
T
EGEIR
L
DG
R
PL
SS
L
S
H
S
A
LR
QG
VAMV
Q
Q
D
P
V
VL
ADT
FLA
N
VT
LG
-
-RDI
SEER
VW
Q
A
LE
T
V
QLA
E
L
A
RS
M
SD
G
I
Y
T
P
LGE
Q
G
N
N
LS
V
GQKQ
LL
A
L
AR
V
L
V
ETPQ
ILILDEAT
AS
ID
SG
TE
Q
AIQHAL
AAVR
E
H
T
T
L
V
VIAHRLSTI
V
DAD
T
I
L
VL
HR
G
Q
A
VE
Q
GTH
QQ
LL
AAQ
G
R
Y
W
QMYQ
L
Q
LA
GEELAASVR
E
EESLSA
fig|340197.3.peg.3780
Escherichia coli F11
MRSFSQLW
P
T
LK
RL
LAYGSP
W
--------
-
R
KPL
G
I
A
V
LMM
WV
A
AAA-
--
E
V
SG
P
LLISYFI
D
N
MVAKNN
L
PLK
V
V
A
G
LA
AA
Y
VGL
QL
FAAG
L
----
---
-
--H
Y
AQ
S
L
L
FNR
A
AVG
VV
QQ
LR
T
D
VMDAAL
RQP
L
S
E
FD
T
Q
P
V
G
Q
V
ISR
V
TND
T
E
VIRDLYV
T
VV
A-------
TV
L
R
SA
ALV
G
A
---
M
L
V
A
MF
SL
D
W
RM
---
A
L
V
A
I
M
I
F
PVV
LV
VMVIYQ
R
YSTP
IV
R
RVR
A
YLA
D
I
ND
----
G
FNE
I
IN
G
MSV
I
QQ
F
R
-----------
QQA
R
FGERMGEASRSHYMAR
MQ
TL
R
L
D
G
F
LL
R
P
L
L
S
L
FS
SL
I
L
CG
LL
M
L
F
G
F
S
---
A
S
G
TIE
V
G
V
L
Y
A
F
I
SYLG
R
L
NE
PL
IE
LT
TQ
-------
Q
A
ML
Q
Q
AV
V
A
GERV
F
E
L
M
DG
P
R
QQ
-----
Y
GNDD
R
PLQ
S
GT
-
-
I
E
VD
NV
S
F
A
Y
-
RD
D
N
LV
LKNINL
S
V
P
S
R
NF
VALVG
H
TGSGKSTLASL
L
M
G
YY
P
L
T
EGEIR
L
DG
R
PL
ST
L
S
H
S
A
LR
QG
VAMV
Q
Q
D
P
V
VL
ADT
FLA
N
VT
LG
-
-RDI
SEER
VW
Q
A
LE
I
V
QLA
E
L
A
RS
M
SD
G
I
Y
T
P
LGE
Q
G
N
N
LS
V
GQKQ
LL
A
L
AR
V
L
V
ETPQ
ILILDEAT
AS
ID
SG
TE
Q
AIQHAL
AAVR
E
H
T
T
L
V
VIAHRLSTI
V
DAD
T
I
L
VL
HR
G
Q
A
VE
Q
GTH
QQ
LL
AAQ
G
R
Y
W
QMYQ
L
Q
LA
GEELAASVR
E
EESLSA
fig|340197.5.peg.3956
Escherichia coli F11
MRSFSQLW
P
T
LK
RL
LAYGSP
W
--------
-
R
KPL
G
I
A
V
LMM
WV
A
AAA-
--
E
V
SG
P
LLISYFI
D
N
MVAKNN
L
PLK
V
V
A
G
LA
AA
Y
VGL
QL
FAAG
L
----
---
-
--H
Y
AQ
S
L
L
FNR
A
AVG
VV
QQ
LR
T
D
VMDAAL
RQP
L
S
E
FD
T
Q
P
V
G
Q
V
ISR
V
TND
T
E
VIRDLYV
T
VV
A-------
TV
L
R
SA
ALV
G
A
---
M
L
V
A
MF
SL
D
W
RM
---
A
L
V
A
I
M
I
F
PVV
LV
VMVIYQ
R
YSTP
IV
R
RVR
A
YLA
D
I
ND
----
G
FNE
I
IN
G
MSV
I
QQ
F
R
-----------
QQA
R
FGERMGEASRSHYMAR
MQ
TL
R
L
D
G
F
LL
R
P
L
L
S
L
FS
SL
I
L
CG
LL
M
L
F
G
F
S
---
A
S
G
TIE
V
G
V
L
Y
A
F
I
SYLG
R
L
NE
PL
IE
LT
TQ
-------
Q
A
ML
Q
Q
AV
V
A
GERV
F
E
L
M
DG
P
R
QQ
-----
Y
GNDD
R
PLQ
S
GT
-
-
I
E
VD
NV
S
F
A
Y
-
RD
D
N
LV
LKNINL
S
V
P
S
R
NF
VALVG
H
TGSGKSTLASL
L
M
G
YY
P
L
T
EGEIR
L
DG
R
PL
ST
L
S
H
S
A
LR
QG
VAMV
Q
Q
D
P
V
VL
ADT
FLA
N
VT
LG
-
-RDI
SEER
VW
Q
A
LE
I
V
QLA
E
L
A
RS
M
SD
G
I
Y
T
P
LGE
Q
G
N
N
LS
V
GQKQ
LL
A
L
AR
V
L
V
ETPQ
ILILDEAT
AS
ID
SG
TE
Q
AIQHAL
AAVR
E
H
T
T
L
V
VIAHRLSTI
V
DAD
T
I
L
VL
HR
G
Q
A
VE
Q
GTH
QQ
LL
AAQ
G
R
Y
W
QMYQ
L
Q
LA
GEELAASVR
E
EESLSA
fig|749550.3.peg.4728
Escherichia coli MS 200-1
MRSFSQLW
P
T
LK
RL
LAYGSP
W
--------
-
R
KPL
G
I
A
V
LMM
WV
A
AAA-
--
E
V
SG
P
LLISYFI
D
N
MVAKNN
L
PLK
V
V
A
G
LA
AA
Y
VGL
QL
FAAG
L
----
---
-
--H
Y
AQ
S
L
L
FNR
A
AVG
VV
QQ
LR
T
D
VMDAAL
RQP
L
S
E
FD
T
Q
P
V
G
Q
V
ISR
V
TND
T
E
VIRDLYV
T
VV
A-------
TV
L
R
SA
ALV
G
A
---
M
L
V
A
MF
SL
D
W
RM
---
A
L
V
A
I
M
I
F
PVV
LV
VMVIYQ
R
YSTP
IV
R
RVR
A
YLA
D
I
ND
----
G
FNE
I
IN
G
MSV
I
QQ
F
R
-----------
QQA
R
FGERMGEASRSHYMAR
MQ
TL
R
L
D
G
F
LL
R
P
L
L
S
L
FS
SL
I
L
CG
LL
M
L
F
G
F
S
---
A
S
G
TIE
V
G
V
L
Y
A
F
I
SYLG
R
L
NE
PL
IE
LT
TQ
-------
Q
A
ML
Q
Q
AV
V
A
GERV
F
E
L
M
DG
P
R
QQ
-----
Y
GNDD
R
PLQ
S
GT
-
-
I
E
VD
NV
S
F
A
Y
-
RD
D
N
LV
LKNINL
S
V
P
S
R
NF
VALVG
H
TGSGKSTLASL
L
M
G
YY
P
L
T
EGEIR
L
DG
R
PL
ST
L
S
H
S
A
LR
QG
VAMV
Q
Q
D
P
V
VL
ADT
FLA
N
VT
LG
-
-RDI
SEER
VW
Q
A
LE
I
V
QLA
E
L
A
RS
M
SD
G
I
Y
T
P
LGE
Q
G
N
N
LS
V
GQKQ
LL
A
L
AR
V
L
V
ETPQ
ILILDEAT
AS
ID
SG
TE
Q
AIQHAL
AAVR
E
H
T
T
L
V
VIAHRLSTI
V
DAD
T
I
L
VL
HR
G
Q
A
VE
Q
GTH
QQ
LL
AAQ
G
R
Y
W
QMYQ
L
Q
LA
GEELAASVR
E
EESLSA
fig|656440.3.peg.326
Escherichia coli TA206
MRSFSQLW
P
T
LK
RL
LAYGSP
W
--------
-
R
KPL
G
I
A
V
LMM
WV
A
AAA-
--
E
V
SG
P
LLISYFI
D
N
MVAKNN
L
PLK
V
V
A
G
LA
AA
Y
VGL
QL
FAAG
L
----
---
-
--H
Y
AQ
S
L
L
FNR
A
AVG
VV
QQ
LR
T
D
VMDAAL
RQP
L
S
E
FD
T
Q
P
V
G
Q
V
ISR
V
TND
T
E
VIRDLYV
T
VV
A-------
TV
L
R
SA
ALV
G
A
---
M
L
V
A
MF
SL
D
W
RM
---
A
L
V
A
I
M
I
F
PVV
LV
VMVIYQ
R
YSTP
IV
R
RVR
A
YLA
D
I
ND
----
G
FNE
I
IN
G
MSV
I
QQ
F
R
-----------
QQA
R
FGERMGEASRSHYMAR
MQ
TL
R
L
D
G
F
LL
R
P
L
L
S
L
FS
SL
I
L
CG
LL
M
L
F
G
F
S
---
A
S
G
TIE
V
G
V
L
Y
A
F
I
SYLG
R
L
NE
PL
IE
LT
TQ
-------
Q
A
ML
Q
Q
AV
V
A
GERV
F
E
L
M
DG
P
R
QQ
-----
Y
GNDD
R
PLQ
S
GT
-
-
I
E
VD
NV
S
F
A
Y
-
RD
D
N
LV
LKNINL
S
V
P
S
R
NF
VALVG
H
TGSGKSTLASL
L
M
G
YY
P
L
T
EGEIR
L
DG
R
PL
ST
L
S
H
S
A
LR
QG
VAMV
Q
Q
D
P
V
VL
ADT
FLA
N
VT
LG
-
-RDI
SEER
VW
Q
A
LE
I
V
QLA
E
L
A
RS
M
SD
G
I
Y
T
P
LGE
Q
G
N
N
LS
V
GQKQ
LL
A
L
AR
V
L
V
ETPQ
ILILDEAT
AS
ID
SG
TE
Q
AIQHAL
AAVR
E
H
T
T
L
V
VIAHRLSTI
V
DAD
T
I
L
VL
HR
G
Q
A
VE
Q
GTH
QQ
LL
AAQ
G
R
Y
W
QMYQ
L
Q
LA
GEELAASVR
E
EESLSA
fig|574521.7.peg.413
Escherichia coli O127:H6 str. E2348/69
MRSFSQLW
P
T
LK
RL
LAYGSP
W
--------
-
R
KPL
G
I
A
V
LMM
WV
A
AAA-
--
E
V
SG
P
LLISYFI
D
N
MVAKNN
L
PLK
V
V
A
G
LA
AA
Y
VGL
QL
FAAG
L
----
---
-
--H
Y
AQ
S
L
L
FNR
A
AVG
VV
QQ
LR
T
D
VMDAAL
RQP
L
S
E
FD
T
Q
P
V
G
Q
V
ISR
V
TND
T
E
VIRDLYV
T
VV
A-------
TV
L
R
SA
ALV
G
A
---
M
L
V
A
MF
SL
D
W
RM
---
A
L
V
A
I
M
I
F
PVV
LV
VMVIYQ
R
YSTP
IV
R
RVR
A
YLA
D
I
ND
----
G
FNE
I
IN
G
MSV
I
QQ
F
R
-----------
QQA
R
FGERMGEASRSHYMAR
MQ
TL
R
L
D
G
F
LL
R
P
L
L
S
L
FS
SL
I
L
CG
LL
M
L
F
G
F
S
---
A
S
G
TIE
V
G
V
L
Y
A
F
I
SYLG
R
L
NE
PL
IE
LT
TQ
-------
Q
A
ML
Q
Q
AV
V
A
GERV
F
E
L
M
DG
P
R
QQ
-----
Y
GNDD
R
PLQ
S
GT
-
-
I
D
VD
NV
S
F
A
Y
-
RD
D
N
LV
LKNINL
S
V
P
S
R
NF
VALVG
H
TGSGKSTLASL
L
M
G
YY
P
L
T
EGEIR
L
DG
R
PL
ST
L
S
H
S
A
LR
QG
V
T
MV
Q
Q
D
P
V
VL
ADT
FLA
N
VT
LG
-
-RDI
SEER
VW
Q
A
LE
T
V
QLA
E
L
A
RS
M
SD
G
I
Y
T
P
LGE
Q
G
N
N
LS
V
GQKQ
LL
A
L
AR
V
L
V
ETPQ
ILILDEAT
AS
ID
SG
TE
Q
AIQHAL
AAVR
E
H
T
T
L
V
VIAHRLSTI
V
DAD
T
I
L
VL
HR
G
Q
A
VE
Q
GTH
QQ
LL
AAQ
G
R
Y
W
QMYQ
L
Q
LA
GEELAASVR
E
EESLSA
fig|439855.10.peg.666
Escherichia coli SMS-3-5
MRSFSQLW
P
T
LK
RL
LAYGSP
W
--------
-
R
KPL
G
I
A
V
LMM
WV
A
AAA-
--
E
V
SG
P
LLISYFI
D
N
MVAKNN
L
PLK
V
V
A
G
LA
AA
Y
VGL
QL
FAAG
L
----
---
-
--H
Y
AQ
S
L
L
FNR
A
AVG
VV
QQ
LR
T
D
VMDAAL
RQP
L
S
E
FD
T
Q
P
V
G
Q
V
ISR
V
TND
T
E
VIRDLYV
T
VV
A-------
TV
L
R
SA
ALV
G
A
---
M
L
V
A
MF
SL
D
W
RM
---
A
L
V
A
I
M
I
F
PVV
LV
VMVIYQ
R
YSTP
IV
R
RVR
A
YLA
D
I
ND
----
G
FNE
I
IN
G
MSV
I
QQ
F
R
-----------
QQA
R
FGERMGEASRSHYMAR
MQ
TL
R
L
D
G
F
LL
R
P
L
L
S
L
FS
SL
I
L
CG
LL
M
L
F
G
F
S
---
V
S
G
TIE
V
G
V
L
Y
A
F
I
SYLG
R
L
NE
PL
IE
LT
TQ
-------
Q
A
ML
Q
Q
AV
V
A
GERV
F
E
L
M
DG
P
R
QQ
-----
Y
GNDD
R
PLQ
S
GT
-
-
I
E
VD
NV
S
F
A
Y
-
RD
D
N
M
V
LKNINL
S
V
P
S
R
NF
VALVG
H
TGSGKSTLASL
L
M
G
YY
P
L
T
EGEIR
L
DG
R
PL
SS
L
S
H
S
A
LR
QG
VAMV
Q
Q
D
P
V
VL
ADT
FLA
N
VT
LG
-
-RDI
SEER
VW
Q
A
LE
T
V
QLT
E
L
A
RS
M
ND
G
I
Y
T
P
LGE
Q
G
N
N
LS
V
GQKQ
LL
A
L
AR
V
L
V
ETPQ
ILILDEAT
AS
ID
SG
TE
Q
AIQHAL
AAVR
E
H
T
T
L
V
VIAHRLSTI
V
DAD
T
I
L
VL
HR
G
Q
A
VE
Q
GTH
QQ
LL
AAQ
G
R
Y
W
QMYQ
L
Q
LA
GEELAASVR
E
EESLSA
fig|550677.3.peg.888
Escherichia coli B354
MRSFSQLW
P
T
LK
RL
LAYGSP
W
--------
-
R
KPL
G
I
A
V
LMM
WV
A
AAA-
--
E
V
SG
P
LLISYFI
D
N
MVAKNN
L
PLK
V
V
A
G
LA
AA
Y
VGL
QL
FAAG
L
----
---
-
--H
Y
AQ
S
L
L
FNR
A
AVG
VV
QQ
LR
T
D
VMDAAL
RQP
L
S
E
FD
T
Q
P
V
G
Q
V
ISR
V
TND
T
E
VIRDLYV
T
VV
A-------
TV
L
R
SA
ALV
G
A
---
M
L
V
A
MF
SL
D
W
RM
---
V
L
V
A
I
M
I
F
PVV
LV
VMVIYQ
R
YSTP
IV
R
RVR
A
YLA
D
I
ND
----
G
FNE
I
IN
G
MSV
I
QQ
F
R
-----------
QQA
R
FGERMGEASRSHYMAR
MQ
TL
R
L
D
G
F
LL
R
P
L
L
S
L
FS
SL
I
L
CG
LL
I
L
F
G
F
S
---
A
S
G
TIE
V
G
V
L
Y
A
F
I
SYLG
R
L
NE
PL
IE
LT
TQ
-------
Q
A
ML
Q
Q
AV
V
A
GERV
F
E
L
M
DG
P
R
QQ
-----
Y
GNDD
R
PLQ
S
GT
-
-
I
E
VD
NV
S
F
A
Y
-
RD
D
N
M
V
LKNINL
S
V
P
S
R
NF
VALVG
H
TGSGKSTLASL
L
M
G
YY
P
L
T
EGEIR
L
DG
R
PL
SS
L
S
H
S
A
LR
QG
VAMV
Q
Q
D
P
V
VL
ADT
FLA
N
VT
LG
-
-RDI
SEER
VW
Q
A
LE
T
V
QLA
E
L
A
RS
M
SD
G
I
Y
T
P
LGE
Q
G
N
N
LS
V
GQKQ
LL
A
L
AR
V
L
V
DTPQ
ILILDEAT
AS
ID
SG
TE
Q
AIQHAL
AAVR
E
H
T
T
L
V
VIAHRLSTI
V
DAD
T
I
L
VL
HR
G
Q
A
VE
Q
GTH
QQ
LL
AAQ
G
R
Y
W
QMYQ
L
Q
LA
GEELAASVR
E
EESLSA
fig|362663.8.peg.510
Escherichia coli 536
MRSFSQLW
P
T
LK
RL
LAYGSP
W
--------
-
R
KPL
G
I
A
V
LMM
WV
A
AAA-
--
E
V
SG
P
LLISYFI
D
N
MVAKNN
L
PLK
V
V
A
G
LA
AA
Y
VGL
QL
FAAG
L
----
---
-
--H
Y
AQ
S
L
L
FNR
A
AVG
VV
QQ
LR
T
D
VMDAAL
RQP
L
S
E
FD
T
Q
P
V
G
Q
V
ISR
V
TND
T
E
VIRDLYV
T
VV
A-------
TV
L
R
SA
ALV
G
A
---
M
L
V
A
MF
SL
D
W
RM
---
A
L
V
A
I
M
I
F
PVV
LV
VMVIYQ
R
YSTP
IV
R
RVR
A
YLA
D
I
ND
----
G
FNE
I
IN
G
MSV
I
QQ
F
R
-----------
QQA
R
FGERMGEASRSHYMAR
MQ
TL
R
L
D
G
F
LL
R
P
L
L
S
L
FS
SL
I
L
CG
LL
M
L
F
G
F
S
---
A
S
G
TIE
V
G
V
L
Y
A
F
I
SYLG
R
L
NE
PL
IE
LT
TQ
-------
Q
A
ML
Q
Q
AV
V
A
GERV
F
E
L
M
DG
P
R
QQ
-----
Y
GNDD
R
PLQ
S
GT
-
-
I
E
VD
NV
S
F
A
Y
-
RD
D
N
LV
LKNINL
S
V
P
S
R
NF
VALVG
H
TGSGKSTLASL
L
M
G
YY
P
L
T
EGEIR
L
DG
R
PL
ST
L
S
H
S
A
LR
QG
VAMV
Q
Q
D
P
V
VL
ADT
FLA
N
VT
LG
-
-RDI
SEER
VW
Q
A
LE
I
V
QLA
E
L
A
RS
M
SD
G
I
Y
T
P
LGE
Q
G
K
N
LS
V
GQKQ
LL
A
L
AR
V
L
V
ETPQ
ILILDEAT
AS
ID
SG
TE
Q
AIQHAL
AAVR
E
H
T
T
L
V
VIAHRLSTI
V
DAD
T
I
L
VL
HR
G
Q
A
VE
Q
GTH
QQ
LL
AAQ
G
R
Y
W
QMYQ
L
Q
LA
GEELAASVR
E
EESLSA
fig|362663.9.peg.510
Escherichia coli 536
MRSFSQLW
P
T
LK
RL
LAYGSP
W
--------
-
R
KPL
G
I
A
V
LMM
WV
A
AAA-
--
E
V
SG
P
LLISYFI
D
N
MVAKNN
L
PLK
V
V
A
G
LA
AA
Y
VGL
QL
FAAG
L
----
---
-
--H
Y
AQ
S
L
L
FNR
A
AVG
VV
QQ
LR
T
D
VMDAAL
RQP
L
S
E
FD
T
Q
P
V
G
Q
V
ISR
V
TND
T
E
VIRDLYV
T
VV
A-------
TV
L
R
SA
ALV
G
A
---
M
L
V
A
MF
SL
D
W
RM
---
A
L
V
A
I
M
I
F
PVV
LV
VMVIYQ
R
YSTP
IV
R
RVR
A
YLA
D
I
ND
----
G
FNE
I
IN
G
MSV
I
QQ
F
R
-----------
QQA
R
FGERMGEASRSHYMAR
MQ
TL
R
L
D
G
F
LL
R
P
L
L
S
L
FS
SL
I
L
CG
LL
M
L
F
G
F
S
---
A
S
G
TIE
V
G
V
L
Y
A
F
I
SYLG
R
L
NE
PL
IE
LT
TQ
-------
Q
A
ML
Q
Q
AV
V
A
GERV
F
E
L
M
DG
P
R
QQ
-----
Y
GNDD
R
PLQ
S
GT
-
-
I
E
VD
NV
S
F
A
Y
-
RD
D
N
LV
LKNINL
S
V
P
S
R
NF
VALVG
H
TGSGKSTLASL
L
M
G
YY
P
L
T
EGEIR
L
DG
R
PL
ST
L
S
H
S
A
LR
QG
VAMV
Q
Q
D
P
V
VL
ADT
FLA
N
VT
LG
-
-RDI
SEER
VW
Q
A
LE
I
V
QLA
E
L
A
RS
M
SD
G
I
Y
T
P
LGE
Q
G
K
N
LS
V
GQKQ
LL
A
L
AR
V
L
V
ETPQ
ILILDEAT
AS
ID
SG
TE
Q
AIQHAL
AAVR
E
H
T
T
L
V
VIAHRLSTI
V
DAD
T
I
L
VL
HR
G
Q
A
VE
Q
GTH
QQ
LL
AAQ
G
R
Y
W
QMYQ
L
Q
LA
GEELAASVR
E
EESLSA
fig|431946.3.peg.425
Escherichia coli SE15
MRSFSQLW
P
T
LK
RL
LAYGSP
W
--------
-
R
KPL
G
I
A
V
LMM
WV
A
AAA-
--
E
V
SG
P
LLISYFI
D
N
MVAKNN
L
PLK
V
V
A
G
LA
AA
Y
VGL
QL
FAAG
L
----
---
-
--H
Y
AQ
S
L
L
FNR
A
AVG
VV
QQ
LR
T
D
VMDAAL
RQP
L
S
E
FD
T
Q
P
V
G
Q
V
ISR
V
TND
T
E
VIRDLYV
T
VV
A-------
TV
L
R
SA
ALV
G
A
---
M
L
V
A
MF
SL
D
W
RM
---
A
L
V
A
I
M
I
F
PVV
LV
VMVIYQ
R
YSTP
IV
R
RVR
A
YLA
D
I
ND
----
G
FNE
I
IN
G
MSV
I
QQ
F
R
-----------
QQA
R
FGERMGEASRSHYMAR
MQ
TL
R
L
D
G
F
LL
R
P
L
L
S
L
FS
SL
I
L
CG
LL
M
L
F
G
F
S
---
A
S
G
TIE
V
G
V
L
Y
A
F
I
SYLG
R
L
NE
PL
IE
LT
TQ
-------
Q
A
ML
Q
Q
AV
V
A
GERV
F
E
L
M
DG
P
R
QQ
-----
Y
GNDD
R
PLQ
S
GT
-
-
I
E
VD
NV
S
F
A
Y
-
RD
D
N
LV
LKNINL
S
V
P
S
R
NF
VALVG
H
TGSGKSTLASL
L
M
G
YY
P
L
T
EGEIR
L
DG
R
PL
ST
L
S
H
S
A
LR
QG
VAMV
Q
Q
D
P
V
VL
ADT
FLA
N
VT
LG
-
-RDI
SEER
VW
Q
A
LE
T
V
QLA
E
L
A
RS
M
SD
G
I
Y
T
L
LGE
Q
G
N
N
LS
V
GQKQ
LL
A
L
AR
V
L
V
ETPQ
ILILDEAT
AS
ID
SG
TE
Q
AIQHAL
AAVR
E
H
T
T
L
V
VIAHRLSTI
V
DAD
T
I
L
VL
HR
G
Q
A
VE
Q
GTH
QQ
LL
AAQ
G
R
Y
W
QMYQ
L
Q
LA
GEELAASVR
E
EESLSA
fig|685038.3.peg.425
Escherichia coli O83:H1 str. NRG 857C
MRSFSQLW
P
T
LK
RL
LAYGSP
W
--------
-
R
KPL
G
I
A
V
LMM
WV
A
AAA-
--
E
V
SG
P
LLISYFI
D
N
MVAKNN
L
PLK
V
V
A
G
LA
AA
Y
VGL
QL
FAAG
L
----
---
-
--H
Y
AQ
S
L
L
FNR
A
AVG
VV
QQ
LR
T
D
VMDAAL
RQP
L
S
E
FD
T
Q
P
V
G
Q
V
ISR
V
TND
T
E
VIRDLYV
T
VV
A-------
TV
L
R
SA
ALV
G
A
---
M
L
V
A
MF
SL
D
W
RM
---
A
L
V
A
I
M
I
F
PVV
LV
VMVIYQ
R
YSTP
IV
R
RVR
A
YLA
D
I
ND
----
G
FNE
I
IN
G
MSV
I
QQ
F
R
-----------
QQA
R
FGERMGEASRSHYMAR
MQ
TL
R
L
D
G
F
LL
R
P
L
L
S
L
FS
SL
I
L
CG
LL
M
L
F
G
F
S
---
A
S
G
TIE
V
G
V
L
Y
A
F
I
SYLG
R
L
NE
PL
IE
LT
TQ
-------
Q
A
ML
Q
Q
AV
V
A
GERV
F
E
L
M
DG
P
R
QQ
-----
Y
GNDD
R
PLQ
S
GT
-
-
I
E
VD
NV
S
F
A
Y
-
RD
D
N
LV
LKNINL
S
V
P
S
R
NF
VALVG
H
TGSGKSTLASL
L
M
G
YY
P
L
T
EGEIR
L
DG
R
PL
ST
L
S
H
S
A
LR
QG
VAMV
Q
Q
D
P
V
VL
ADT
FLA
N
VT
LG
-
-RDI
SEER
VW
Q
A
LE
I
V
QLA
E
L
A
RS
M
SD
G
I
Y
T
P
LGE
Q
G
N
N
LS
V
GQKQ
LL
A
L
AR
V
L
V
ETPQ
ILILDEAT
AS
ID
SG
TE
Q
AIQHAL
AAVR
E
H
T
T
L
V
VIAHRLSTI
V
DA
N
T
I
L
VL
HR
G
Q
A
VE
Q
GTH
QQ
LL
AAQ
G
R
Y
W
QMYQ
L
Q
LV
GEELAASVR
E
EESLSA
fig|405955.13.peg.452
Escherichia coli APEC O1
MRSFSQLW
P
T
LK
RL
LAYGSP
W
--------
-
R
KPL
G
I
A
V
LMM
WV
A
AAA-
--
E
V
SG
P
LLISYFI
D
N
MVAKNN
L
PLK
V
G
A
G
LA
AA
Y
VGL
QL
FAAG
L
----
---
-
--H
Y
AQ
S
L
L
FNR
A
AVG
VV
QQ
LR
T
D
VMDAAL
RQP
L
S
E
FD
T
Q
P
V
G
Q
V
ISR
V
TND
T
E
VIRDLYV
T
VV
A-------
TV
L
R
SA
ALV
G
A
---
M
L
V
A
MF
SL
D
W
RM
---
A
L
V
A
I
M
I
F
PVV
LV
VMVIYQ
R
YSTP
IV
R
RVR
A
YLA
D
I
ND
----
G
FNE
I
IN
G
MSV
I
QQ
F
R
-----------
QQA
R
FGERMGEASRSHYMAR
MQ
TL
R
L
D
G
F
LL
R
P
L
L
S
L
FS
SL
I
L
CG
LL
M
L
F
G
F
S
---
A
S
G
TIE
V
G
V
L
Y
A
F
I
SYLG
R
L
NE
PL
IE
LT
TQ
-------
Q
A
ML
Q
Q
AV
V
A
GERV
F
E
L
M
DG
P
R
QQ
-----
Y
GNDD
R
PLQ
S
GT
-
-
I
D
VD
NV
S
F
A
Y
-
RD
D
N
LV
LKNINL
S
V
P
S
R
NF
VALVG
H
TGSGKSTLASL
L
M
G
YY
P
L
T
EGEIR
L
DG
R
PL
ST
L
S
H
S
A
LR
QG
VAMV
Q
Q
D
P
V
VL
ADT
FLA
N
VT
LG
-
-RDI
SEER
VW
Q
A
LE
I
V
QLA
E
L
A
RS
M
SD
G
I
Y
T
P
LGE
Q
G
N
N
LS
V
GQKQ
LL
A
L
AR
V
L
V
ETPQ
ILILDEAT
AS
ID
SG
TE
Q
AIQHAL
AAVR
E
H
T
T
L
V
VIAHRLSTI
V
DAD
T
I
L
VL
HR
G
Q
A
VE
Q
GTH
QQ
LL
AAQ
G
R
Y
W
QMYQ
L
Q
LA
GEELAASVR
E
EESLSA
fig|714962.3.peg.442
Escherichia coli IHE3034
MRSFSQLW
P
T
LK
RL
LAYGSP
W
--------
-
R
KPL
G
I
A
V
LMM
WV
A
AAA-
--
E
V
SG
P
LLISYFI
D
N
MVAKNN
L
PLK
V
G
A
G
LA
AA
Y
VGL
QL
FAAG
L
----
---
-
--H
Y
AQ
S
L
L
FNR
A
AVG
VV
QQ
LR
T
D
VMDAAL
RQP
L
S
E
FD
T
Q
P
V
G
Q
V
ISR
V
TND
T
E
VIRDLYV
T
VV
A-------
TV
L
R
SA
ALV
G
A
---
M
L
V
A
MF
SL
D
W
RM
---
A
L
V
A
I
M
I
F
PVV
LV
VMVIYQ
R
YSTP
IV
R
RVR
A
YLA
D
I
ND
----
G
FNE
I
IN
G
MSV
I
QQ
F
R
-----------
QQA
R
FGERMGEASRSHYMAR
MQ
TL
R
L
D
G
F
LL
R
P
L
L
S
L
FS
SL
I
L
CG
LL
M
L
F
G
F
S
---
A
S
G
TIE
V
G
V
L
Y
A
F
I
SYLG
R
L
NE
PL
IE
LT
TQ
-------
Q
A
ML
Q
Q
AV
V
A
GERV
F
E
L
M
DG
P
R
QQ
-----
Y
GNDD
R
PLQ
S
GT
-
-
I
D
VD
NV
S
F
A
Y
-
RD
D
N
LV
LKNINL
S
V
P
S
R
NF
VALVG
H
TGSGKSTLASL
L
M
G
YY
P
L
T
EGEIR
L
DG
R
PL
ST
L
S
H
S
A
LR
QG
VAMV
Q
Q
D
P
V
VL
ADT
FLA
N
VT
LG
-
-RDI
SEER
VW
Q
A
LE
I
V
QLA
E
L
A
RS
M
SD
G
I
Y
T
P
LGE
Q
G
N
N
LS
V
GQKQ
LL
A
L
AR
V
L
V
ETPQ
ILILDEAT
AS
ID
SG
TE
Q
AIQHAL
AAVR
E
H
T
T
L
V
VIAHRLSTI
V
DAD
T
I
L
VL
HR
G
Q
A
VE
Q
GTH
QQ
LL
AAQ
G
R
Y
W
QMYQ
L
Q
LA
GEELAASVR
E
EESLSA
fig|585035.6.peg.445
Escherichia coli S88
MRSFSQLW
P
T
LK
RL
LAYGSP
W
--------
-
R
KPL
G
I
A
V
LMM
WV
A
AAA-
--
E
V
SG
P
LLISYFI
D
N
MVAKNN
L
PLK
V
G
A
G
LA
AA
Y
VGL
QL
FAAG
L
----
---
-
--H
Y
AQ
S
L
L
FNR
A
AVG
VV
QQ
LR
T
D
VMDAAL
RQP
L
S
E
FD
T
Q
P
V
G
Q
V
ISR
V
TND
T
E
VIRDLYV
T
VV
A-------
TV
L
R
SA
ALV
G
A
---
M
L
V
A
MF
SL
D
W
RM
---
A
L
V
A
I
M
I
F
PVV
LV
VMVIYQ
R
YSTP
IV
R
RVR
A
YLA
D
I
ND
----
G
FNE
I
IN
G
MSV
I
QQ
F
R
-----------
QQA
R
FGERMGEASRSHYMAR
MQ
TL
R
L
D
G
F
LL
R
P
L
L
S
L
FS
SL
I
L
CG
LL
M
L
F
G
F
S
---
A
S
G
TIE
V
G
V
L
Y
A
F
I
SYLG
R
L
NE
PL
IE
LT
TQ
-------
Q
A
ML
Q
Q
AV
V
A
GERV
F
E
L
M
DG
P
R
QQ
-----
Y
GNDD
R
PLQ
S
GT
-
-
I
D
VD
NV
S
F
A
Y
-
RD
D
N
LV
LKNINL
S
V
P
S
R
NF
VALVG
H
TGSGKSTLASL
L
M
G
YY
P
L
T
EGEIR
L
DG
R
PL
ST
L
S
H
S
A
LR
QG
VAMV
Q
Q
D
P
V
VL
ADT
FLA
N
VT
LG
-
-RDI
SEER
VW
Q
A
LE
I
V
QLA
E
L
A
RS
M
SD
G
I
Y
T
P
LGE
Q
G
N
N
LS
V
GQKQ
LL
A
L
AR
V
L
V
ETPQ
ILILDEAT
AS
ID
SG
TE
Q
AIQHAL
AAVR
E
H
T
T
L
V
VIAHRLSTI
V
DAD
T
I
L
VL
HR
G
Q
A
VE
Q
GTH
QQ
LL
AAQ
G
R
Y
W
QMYQ
L
Q
LA
GEELAASVR
E
EESLSA
fig|869729.3.peg.3235
Escherichia coli UM146
MRSFSQLW
P
T
LK
RL
LAYGSP
W
--------
-
R
KPL
G
I
A
V
LMM
WV
A
AAA-
--
E
V
SG
P
LLISYFI
D
N
MVAKNN
L
PLK
V
G
A
G
LA
AA
Y
VGL
QL
FAAG
L
----
---
-
--H
Y
AQ
S
L
L
FNR
A
AVG
VV
QQ
LR
T
D
VMDAAL
RQP
L
S
E
FD
T
Q
P
V
G
Q
V
ISR
V
TND
T
E
VIRDLYV
T
VV
A-------
TV
L
R
SA
ALV
G
A
---
M
L
V
A
MF
SL
D
W
RM
---
A
L
V
A
I
M
I
F
PVV
LV
VMVIYQ
R
YSTP
IV
R
RVR
A
YLA
D
I
ND
----
G
FNE
I
IN
G
MSV
I
QQ
F
R
-----------
QQA
R
FGERMGEASRSHYMAR
MQ
TL
R
L
D
G
F
LL
R
P
L
L
S
L
FS
SL
I
L
CG
LL
M
L
F
G
F
S
---
A
S
G
TIE
V
G
V
L
Y
A
F
I
SYLG
R
L
NE
PL
IE
LT
TQ
-------
Q
A
ML
Q
Q
AV
V
A
GERV
F
E
L
M
DG
P
R
QQ
-----
Y
GNDD
R
PLQ
S
GT
-
-
I
D
VD
NV
S
F
A
Y
-
RD
D
N
LV
LKNINL
S
V
P
S
R
NF
VALVG
H
TGSGKSTLASL
L
M
G
YY
P
L
T
EGEIR
L
DG
R
PL
ST
L
S
H
S
A
LR
QG
VAMV
Q
Q
D
P
V
VL
ADT
FLA
N
VT
LG
-
-RDI
SEER
VW
Q
A
LE
I
V
QLA
E
L
A
RS
M
SD
G
I
Y
T
P
LGE
Q
G
N
N
LS
V
GQKQ
LL
A
L
AR
V
L
V
ETPQ
ILILDEAT
AS
ID
SG
TE
Q
AIQHAL
AAVR
E
H
T
T
L
V
VIAHRLSTI
V
DAD
T
I
L
VL
HR
G
Q
A
VE
Q
GTH
QQ
LL
AAQ
G
R
Y
W
QMYQ
L
Q
LA
GEELAASVR
E
EESLSA
fig|364106.7.peg.583
Escherichia coli UTI89
MRSFSQLW
P
T
LK
RL
LAYGSP
W
--------
-
R
KPL
G
I
A
V
LMM
WV
A
AAA-
--
E
V
SG
P
LLISYFI
D
N
MVAKNN
L
PLK
V
G
A
G
LA
AA
Y
VGL
QL
FAAG
L
----
---
-
--H
Y
AQ
S
L
L
FNR
A
AVG
VV
QQ
LR
T
D
VMDAAL
RQP
L
S
E
FD
T
Q
P
V
G
Q
V
ISR
V
TND
T
E
VIRDLYV
T
VV
A-------
TV
L
R
SA
ALV
G
A
---
M
L
V
A
MF
SL
D
W
RM
---
A
L
V
A
I
M
I
F
PVV
LV
VMVIYQ
R
YSTP
IV
R
RVR
A
YLA
D
I
ND
----
G
FNE
I
IN
G
MSV
I
QQ
F
R
-----------
QQA
R
FGERMGEASRSHYMAR
MQ
TL
R
L
D
G
F
LL
R
P
L
L
S
L
FS
SL
I
L
CG
LL
M
L
F
G
F
S
---
A
S
G
TIE
V
G
V
L
Y
A
F
I
SYLG
R
L
NE
PL
IE
LT
TQ
-------
Q
A
ML
Q
Q
AV
V
A
GERV
F
E
L
M
DG
P
R
QQ
-----
Y
GNDD
R
PLQ
S
GT
-
-
I
D
VD
NV
S
F
A
Y
-
RD
D
N
LV
LKNINL
S
V
P
S
R
NF
VALVG
H
TGSGKSTLASL
L
M
G
YY
P
L
T
EGEIR
L
DG
R
PL
ST
L
S
H
S
A
LR
QG
VAMV
Q
Q
D
P
V
VL
ADT
FLA
N
VT
LG
-
-RDI
SEER
VW
Q
A
LE
I
V
QLA
E
L
A
RS
M
SD
G
I
Y
T
P
LGE
Q
G
N
N
LS
V
GQKQ
LL
A
L
AR
V
L
V
ETPQ
ILILDEAT
AS
ID
SG
TE
Q
AIQHAL
AAVR
E
H
T
T
L
V
VIAHRLSTI
V
DAD
T
I
L
VL
HR
G
Q
A
VE
Q
GTH
QQ
LL
AAQ
G
R
Y
W
QMYQ
L
Q
LA
GEELAASVR
E
EESLSA
fig|364106.8.peg.581
Escherichia coli UTI89
MRSFSQLW
P
T
LK
RL
LAYGSP
W
--------
-
R
KPL
G
I
A
V
LMM
WV
A
AAA-
--
E
V
SG
P
LLISYFI
D
N
MVAKNN
L
PLK
V
G
A
G
LA
AA
Y
VGL
QL
FAAG
L
----
---
-
--H
Y
AQ
S
L
L
FNR
A
AVG
VV
QQ
LR
T
D
VMDAAL
RQP
L
S
E
FD
T
Q
P
V
G
Q
V
ISR
V
TND
T
E
VIRDLYV
T
VV
A-------
TV
L
R
SA
ALV
G
A
---
M
L
V
A
MF
SL
D
W
RM
---
A
L
V
A
I
M
I
F
PVV
LV
VMVIYQ
R
YSTP
IV
R
RVR
A
YLA
D
I
ND
----
G
FNE
I
IN
G
MSV
I
QQ
F
R
-----------
QQA
R
FGERMGEASRSHYMAR
MQ
TL
R
L
D
G
F
LL
R
P
L
L
S
L
FS
SL
I
L
CG
LL
M
L
F
G
F
S
---
A
S
G
TIE
V
G
V
L
Y
A
F
I
SYLG
R
L
NE
PL
IE
LT
TQ
-------
Q
A
ML
Q
Q
AV
V
A
GERV
F
E
L
M
DG
P
R
QQ
-----
Y
GNDD
R
PLQ
S
GT
-
-
I
D
VD
NV
S
F
A
Y
-
RD
D
N
LV
LKNINL
S
V
P
S
R
NF
VALVG
H
TGSGKSTLASL
L
M
G
YY
P
L
T
EGEIR
L
DG
R
PL
ST
L
S
H
S
A
LR
QG
VAMV
Q
Q
D
P
V
VL
ADT
FLA
N
VT
LG
-
-RDI
SEER
VW
Q
A
LE
I
V
QLA
E
L
A
RS
M
SD
G
I
Y
T
P
LGE
Q
G
N
N
LS
V
GQKQ
LL
A
L
AR
V
L
V
ETPQ
ILILDEAT
AS
ID
SG
TE
Q
AIQHAL
AAVR
E
H
T
T
L
V
VIAHRLSTI
V
DAD
T
I
L
VL
HR
G
Q
A
VE
Q
GTH
QQ
LL
AAQ
G
R
Y
W
QMYQ
L
Q
LA
GEELAASVR
E
EESLSA
fig|656393.3.peg.1100
Escherichia coli H299
MRSFSQLW
P
T
LK
RL
LAYGSP
W
--------
-
R
KPL
G
I
A
V
I
MM
WV
A
AAA-
--
E
V
SG
P
LLISYFI
D
N
MVAKNN
L
PLK
V
V
A
G
LA
AA
Y
VGL
QL
FAAG
L
----
---
-
--H
Y
AQ
S
L
L
FNR
A
AVG
VV
QQ
LR
T
D
VMDAAL
RQP
L
S
E
FD
T
Q
P
V
G
Q
V
ISR
V
TND
T
E
VIRDLYV
T
VV
A-------
TV
L
R
SA
ALV
G
A
---
M
L
V
A
MF
SL
D
W
RM
---
A
L
V
A
I
M
I
F
PVV
LV
VMVIYQ
R
YSTP
IV
R
RVR
A
YLA
D
I
ND
----
G
FNE
I
IN
G
MSV
I
QQ
F
R
-----------
QQA
R
FGERMGEASRSHYMAR
MQ
TL
R
L
D
G
F
LL
R
P
L
L
S
L
FS
SL
I
L
CG
LL
M
L
F
G
F
S
---
A
S
G
TIE
V
G
V
L
Y
A
F
I
SYLG
R
L
NE
PL
IE
LT
TQ
-------
Q
A
ML
Q
Q
AV
V
A
GERV
F
E
L
M
DG
P
R
QQ
-----
Y
GNDD
R
PLQ
S
GT
-
-
I
D
VD
NV
S
F
A
Y
-
RD
D
N
LV
LKNINL
S
V
P
S
R
NF
VALVG
H
TGSGKSTLASL
L
M
G
YY
P
L
T
EGEIR
L
DG
R
PL
ST
L
S
H
S
A
LR
QG
VAMV
Q
Q
D
P
V
VL
ADT
FLA
N
VT
LG
-
-RDI
SEER
VW
Q
A
LE
I
V
QLA
E
L
A
RS
M
SD
G
I
Y
T
P
LGE
Q
G
N
N
LS
V
GQKQ
LL
A
L
AR
V
L
V
ETPQ
ILILDEAT
AS
ID
SG
TE
Q
AIQHAL
AAVR
E
H
T
T
L
V
VIAHRLSTI
V
DA
N
T
I
L
VL
HR
G
Q
A
VE
Q
GTH
QQ
LL
AAQ
G
R
Y
W
QMYQ
L
Q
LA
GEELAASVR
E
EESLSA
fig|562.376.peg.703
Escherichia coli WV_060327
MRSFSQLW
P
T
LK
RL
LAYGSP
W
--------
-
R
KPL
G
I
A
V
LMM
WV
A
AAA-
--
E
V
SG
P
LLISYFI
D
N
MVAKNN
L
PLK
V
V
A
G
LA
AA
Y
VGL
QL
FAAG
L
----
---
-
--H
Y
AQ
S
L
L
FNR
A
AVG
VV
QQ
LR
T
D
VMDAAL
RQP
L
S
E
FD
T
Q
P
V
G
Q
V
ISR
V
TND
T
E
VIRDLYV
T
VV
A-------
TV
L
R
SA
ALV
G
A
---
M
L
V
A
MF
SL
D
W
RM
---
A
L
V
A
I
M
I
F
PVV
LV
VMVIYQ
R
YSTP
IV
R
RVR
A
YLA
D
I
ND
----
G
FNE
I
IN
G
MSV
I
QQ
F
R
-----------
QQA
R
FGERMGEASRSHYMAR
MQ
TL
R
L
D
G
F
LL
R
P
L
L
S
L
FS
SL
I
L
CG
LL
M
L
F
G
F
S
---
A
S
G
TIE
V
G
V
L
Y
A
F
I
SYLG
R
L
NE
PL
IE
LT
TQ
-------
Q
A
ML
Q
Q
AV
V
A
GERV
F
E
L
M
DG
P
R
QQ
-----
Y
GNDD
R
PLQ
S
GT
-
-
I
D
VD
NV
S
F
A
Y
-
RD
D
N
LV
LKNINL
S
V
P
S
R
NF
VALVG
H
TGSGKSTLASL
L
M
G
YY
P
L
T
EGEIR
L
DG
R
PL
ST
L
S
H
S
A
LR
QG
VAMV
Q
Q
D
P
V
VL
ADT
FLA
N
VT
LG
-
-RDI
SEER
VW
Q
A
LE
T
V
QLA
E
L
A
RS
M
SD
G
I
Y
T
L
LGE
Q
G
N
N
LS
V
GQKQ
LL
A
L
AR
V
L
V
ETPQ
ILILDEAT
AS
ID
SG
TE
Q
AIQHAL
AAVR
E
H
T
T
L
V
VIAHRLSTI
V
DAD
T
I
L
VL
HR
G
Q
A
VE
Q
GTH
QQ
LL
AAQ
G
R
Y
W
QMYQ
L
Q
LA
GEELAASVR
E
EESLSA
fig|656417.3.peg.592
Escherichia coli M605
MRSFSQLW
P
T
LK
RL
LAYGSP
W
--------
-
R
KPL
G
I
A
V
LMM
WV
A
AAA-
--
E
V
SG
P
LLISYFI
D
N
MVAKNN
L
PLK
V
V
A
G
LA
AA
Y
VGL
QL
FAAG
L
----
---
-
--H
Y
AQ
S
L
L
FNR
A
AVG
VV
QQ
LR
T
D
VMDAAL
RQP
L
S
E
FD
T
Q
P
V
G
Q
V
ISR
V
TND
T
E
VIRDLYV
T
VV
A-------
TV
L
R
SA
ALV
G
A
---
M
L
V
A
MF
SL
D
W
RM
---
A
L
V
A
I
M
I
F
PVV
LV
VMVIYQ
R
YSTP
IV
R
RVR
A
YLA
D
I
ND
----
G
FNE
I
IN
G
MSV
I
QQ
F
R
-----------
QQA
R
FGERMGEASRSHYMAR
MQ
TL
R
L
D
G
F
LL
R
P
L
L
S
L
FS
SL
I
L
CG
LL
M
L
F
G
F
S
---
A
S
G
TIE
V
G
V
L
Y
A
F
I
SYLG
R
L
NE
PL
IE
LT
TQ
-------
Q
A
ML
Q
Q
AV
V
A
GERV
F
E
L
M
DG
P
R
QQ
-----
Y
GNDD
R
SLQ
S
GT
-
-
I
D
VD
NV
S
F
A
Y
-
RD
D
N
LV
LKNINL
S
V
P
S
R
NF
VALVG
H
TGSGKSTLASL
L
M
G
YY
P
L
T
EGEIR
L
DG
R
PL
ST
L
S
H
S
A
LR
QG
VAMV
Q
Q
D
P
V
VL
ADT
FLA
N
VT
LG
-
-RDI
SEER
VW
Q
A
LE
T
V
QLA
E
L
A
RS
M
SD
G
I
Y
T
L
LGE
Q
G
N
N
LS
V
GQKQ
LL
A
L
AR
V
L
V
ETPQ
ILILDEAT
AS
ID
SG
TE
Q
AIQHAL
AAVR
E
H
T
T
L
V
VIAHRLSTI
V
DAD
T
I
L
VL
HR
G
Q
A
VE
Q
GTH
QQ
LL
AAQ
G
R
Y
W
QMYQ
L
Q
LA
GEELAASVR
E
EESLSA
fig|344601.3.peg.2688
Escherichia coli B171 (11-581/582)
Q
TFRRL
------
W
PTIAPFKA
G
L
IVA
GVAL
-
IL
NA
A
SDTF
ML
S
L
LK
P
----LLD
DG
FGK---
T
DRS
VL
V
W
M
P
LV
V
I
GL
MI
----
L
RG
--
ITS
Y
VSS
Y
CI
S
W
V
SG-
-
--K
VV
MT
M
R
R
R
LFDHMM
GM
P
V
SFFD
K
Q
S
TG
T
L
L
SR
I
T
Y
D
S
E
-------
Q
V
A
SSSSGALI
TVVR
EG
A
SI
I
G
---
L
F
I
MMF
YY
SWQL
-
SI
I
L
I
V
L
A
P
I
VS
I
AI
------
R
VVSK
RFR
NIS
K
NMQ
N
T
MG
QVTT
S
AEQ
M
LK
G
HKE
V
LI
FG
GQEVETKRFDK
VSN
R
MRLQ-----------G
M
K
MV
S
A
S
S
-
IS
DP
I
I
Q
L
IA
SLAL
--
AF
V
L
Y
A
A
S
FPS
V
M
D
SLT
A
G
T
I
T
V
V
F
S
SMI
A
L
MR
PL
KS
LT
NV
-------
N
A
QF
QR
GM
AA
CQTL
F
T
I
L
D
S
E
Q
EK
------
DEGK
R
VIE
R
A
T
G
DVE
FR
NV
T
FTYP
GR
D
V
PAL
R
NINL
K
IP
A
G
KT
VALVG
R
S
GSGKST
I
ASLI
T
R
F
YD
I
D
EGEI
L
M
DG
H
D
L
RE
Y
T
L
A
SLR
NQ
VA
L
VSQ
N
V
H
LF
N
DTVANNIA
YAR
TEQY
S
R
E
Q
IE
E
AAR
M
A
YAM
D
F
I
NK
M
DN
G
L
DT
V
I
GE
N
GV
L
LSGGQ
R
QRIAIARALL
RDSP
ILILDEATSA
L
D
TE
S
E
R
AIQ
A
AL
DELQ
K
N
RT
S
LVIAHRLSTI
E
K
ADEIVV
V
ED
G
V
IVERGTH
ND
LL
EHR
G
V
Y
A
Q
LH
K
M
Q
FG
fig|344601.5.peg.2796
Escherichia coli B171 (11-581/582)
Q
TFRRL
------
W
PTIAPFKA
G
L
IVA
GVAL
-
IL
NA
A
SDTF
ML
S
L
LK
P
----LLD
DG
FGK---
T
DRS
VL
V
W
M
P
LV
V
I
GL
MI
----
L
RG
--
ITS
Y
VSS
Y
CI
S
W
V
SG-
-
--K
VV
MT
M
R
R
R
LFDHMM
GM
P
V
SFFD
K
Q
S
TG
T
L
L
SR
I
T
Y
D
S
E
-------
Q
V
A
SSSSGALI
TVVR
EG
A
SI
I
G
---
L
F
I
MMF
YY
SWQL
-
SI
I
L
I
V
L
A
P
I
VS
I
AI
------
R
VVSK
RFR
NIS
K
NMQ
N
T
MG
QVTT
S
AEQ
M
LK
G
HKE
V
LI
FG
GQEVETKRFDK
VSN
R
MRLQ-----------G
M
K
MV
S
A
S
S
-
IS
DP
I
I
Q
L
IA
SLAL
--
AF
V
L
Y
A
A
S
FPS
V
M
D
SLT
A
G
T
I
T
V
V
F
S
SMI
A
L
MR
PL
KS
LT
NV
-------
N
A
QF
QR
GM
AA
CQTL
F
T
I
L
D
S
E
Q
EK
------
DEGK
R
VIE
R
A
T
G
DVE
FR
NV
T
FTYP
GR
D
V
PAL
R
NINL
K
IP
A
G
KT
VALVG
R
S
GSGKST
I
ASLI
T
R
F
YD
I
D
EGEI
L
M
DG
H
D
L
RE
Y
T
L
A
SLR
NQ
VA
L
VSQ
N
V
H
LF
N
DTVANNIA
YAR
TEQY
S
R
E
Q
IE
E
AAR
M
A
YAM
D
F
I
NK
M
DN
G
L
DT
V
I
GE
N
GV
L
LSGGQ
R
QRIAIARALL
RDSP
ILILDEATSA
L
D
TE
S
E
R
AIQ
A
AL
DELQ
K
N
RT
S
LVIAHRLSTI
E
K
ADEIVV
V
ED
G
V
IVERGTH
ND
LL
EHR
G
V
Y
A
Q
LH
K
M
Q
FG
fig|340185.3.peg.3030
Escherichia coli E22 (11-581/582)
Q
TFRRL
------
W
PTIAPFKA
G
L
IVA
GVAL
-
IL
NA
A
SDTF
ML
S
L
LK
P
----LLD
DG
FGK---
T
DRS
VL
V
W
M
P
LV
V
I
GL
MI
----
L
RG
--
ITS
Y
VSS
Y
CI
S
W
V
SG-
-
--K
VV
MT
M
R
R
R
LFDHMM
GM
P
V
SFFD
K
Q
S
TG
T
L
L
SR
I
T
Y
D
S
E
-------
Q
V
A
SSSSGALI
TVVR
EG
A
SI
I
G
---
L
F
I
MMF
YY
SWQL
-
SI
I
L
I
V
L
A
P
I
VS
I
AI
------
R
VVSK
RFR
NIS
K
NMQ
N
T
MG
QVTT
S
AEQ
M
LK
G
HKE
V
LI
FG
GQEVETKRFDK
VSN
R
MRLQ-----------G
M
K
MV
S
A
S
S
-
IS
DP
I
I
Q
L
IA
SLAL
--
AF
V
L
Y
A
A
S
FPS
V
M
D
SLT
A
G
T
I
T
V
V
F
S
SMI
A
L
MR
PL
KS
LT
NV
-------
N
A
QF
QR
GM
AA
CQTL
F
T
I
L
D
S
E
Q
EK
------
DEGK
R
VIE
R
A
T
G
DVE
FR
NV
T
FTYP
GR
D
V
PAL
R
NINL
K
IP
A
G
KT
VALVG
R
S
GSGKST
I
ASLI
T
R
F
YD
I
D
EGEI
L
M
DG
H
D
L
RE
Y
T
L
A
SLR
NQ
VA
L
VSQ
N
V
H
LF
N
DTVANNIA
YAR
TEQY
S
R
E
Q
IE
E
AAR
M
A
YAM
D
F
I
NK
M
DN
G
L
DT
V
I
GE
N
GV
L
LSGGQ
R
QRIAIARALL
RDSP
ILILDEATSA
L
D
TE
S
E
R
AIQ
A
AL
DELQ
K
N
RT
S
LVIAHRLSTI
E
K
ADEIVV
V
ED
G
V
IVERGTH
ND
LL
EHR
G
V
Y
A
Q
LH
K
M
Q
FG
fig|340185.4.peg.3196
Escherichia coli E22 (11-581/582)
Q
TFRRL
------
W
PTIAPFKA
G
L
IVA
GVAL
-
IL
NA
A
SDTF
ML
S
L
LK
P
----LLD
DG
FGK---
T
DRS
VL
V
W
M
P
LV
V
I
GL
MI
----
L
RG
--
ITS
Y
VSS
Y
CI
S
W
V
SG-
-
--K
VV
MT
M
R
R
R
LFDHMM
GM
P
V
SFFD
K
Q
S
TG
T
L
L
SR
I
T
Y
D
S
E
-------
Q
V
A
SSSSGALI
TVVR
EG
A
SI
I
G
---
L
F
I
MMF
YY
SWQL
-
SI
I
L
I
V
L
A
P
I
VS
I
AI
------
R
VVSK
RFR
NIS
K
NMQ
N
T
MG
QVTT
S
AEQ
M
LK
G
HKE
V
LI
FG
GQEVETKRFDK
VSN
R
MRLQ-----------G
M
K
MV
S
A
S
S
-
IS
DP
I
I
Q
L
IA
SLAL
--
AF
V
L
Y
A
A
S
FPS
V
M
D
SLT
A
G
T
I
T
V
V
F
S
SMI
A
L
MR
PL
KS
LT
NV
-------
N
A
QF
QR
GM
AA
CQTL
F
T
I
L
D
S
E
Q
EK
------
DEGK
R
VIE
R
A
T
G
DVE
FR
NV
T
FTYP
GR
D
V
PAL
R
NINL
K
IP
A
G
KT
VALVG
R
S
GSGKST
I
ASLI
T
R
F
YD
I
D
EGEI
L
M
DG
H
D
L
RE
Y
T
L
A
SLR
NQ
VA
L
VSQ
N
V
H
LF
N
DTVANNIA
YAR
TEQY
S
R
E
Q
IE
E
AAR
M
A
YAM
D
F
I
NK
M
DN
G
L
DT
V
I
GE
N
GV
L
LSGGQ
R
QRIAIARALL
RDSP
ILILDEATSA
L
D
TE
S
E
R
AIQ
A
AL
DELQ
K
N
RT
S
LVIAHRLSTI
E
K
ADEIVV
V
ED
G
V
IVERGTH
ND
LL
EHR
G
V
Y
A
Q
LH
K
M
Q
FG
fig|585395.4.peg.1009
Escherichia coli O103:H2 str. 12009 (11-581/582)
Q
TFRRL
------
W
PTIAPFKA
G
L
IVA
GVAL
-
IL
NA
A
SDTF
ML
S
L
LK
P
----LLD
DG
FGK---
T
DRS
VL
V
W
M
P
LV
V
I
GL
MI
----
L
RG
--
ITS
Y
VSS
Y
CI
S
W
V
SG-
-
--K
VV
MT
M
R
R
R
LFDHMM
GM
P
V
SFFD
K
Q
S
TG
T
L
L
SR
I
T
Y
D
S
E
-------
Q
V
A
SSSSGALI
TVVR
EG
A
SI
I
G
---
L
F
I
MMF
YY
SWQL
-
SI
I
L
I
V
L
A
P
I
VS
I
AI
------
R
VVSK
RFR
NIS
K
NMQ
N
T
MG
QVTT
S
AEQ
M
LK
G
HKE
V
LI
FG
GQEVETKRFDK
VSN
R
MRLQ-----------G
M
K
MV
S
A
S
S
-
IS
DP
I
I
Q
L
IA
SLAL
--
AF
V
L
Y
A
A
S
FPS
V
M
D
SLT
A
G
T
I
T
V
V
F
S
SMI
A
L
MR
PL
KS
LT
NV
-------
N
A
QF
QR
GM
AA
CQTL
F
T
I
L
D
S
E
Q
EK
------
DEGK
R
VIE
R
A
T
G
DVE
FR
NV
T
FTYP
GR
D
V
PAL
R
NINL
K
IP
A
G
KT
VALVG
R
S
GSGKST
I
ASLI
T
R
F
YD
I
D
EGEI
L
M
DG
H
D
L
RE
Y
T
L
A
SLR
NQ
VA
L
VSQ
N
V
H
LF
N
DTVANNIA
YAR
TEQY
S
R
E
Q
IE
E
AAR
M
A
YAM
D
F
I
NK
M
DN
G
L
DT
V
I
GE
N
GV
L
LSGGQ
R
QRIAIARALL
RDSP
ILILDEATSA
L
D
TE
S
E
R
AIQ
A
AL
DELQ
K
N
RT
S
LVIAHRLSTI
E
K
ADEIVV
V
ED
G
V
IVERGTH
ND
LL
EHR
G
V
Y
A
Q
LH
K
M
Q
FG
fig|670897.3.peg.4672
Escherichia coli 2362-75 (11-581/582)
Q
TFRRL
------
W
PTIAPFKA
G
L
IVA
GVAL
-
IL
NA
A
SDTF
ML
S
L
LK
P
----LLD
DG
FGK---
T
DRS
VL
M
W
M
P
LV
V
I
GL
MI
----
L
RG
--
ITS
Y
ISS
Y
CI
S
W
V
SG-
-
--K
VV
MT
M
R
R
R
LFGHMM
GM
P
V
SFFD
K
Q
S
TG
T
L
L
SR
I
T
Y
D
S
E
-------
Q
V
A
SSSSGALI
TVVR
EG
A
SI
I
G
---
L
F
I
MMF
YY
SWQL
-
SI
I
L
I
V
L
A
P
I
VS
I
AI
------
R
VVSK
RFR
NIS
K
NMQ
N
T
MG
QVTT
S
AEQ
M
LK
G
HKE
V
LI
FG
GQEVETKRFDK
VSN
R
MRLQ-----------G
M
K
MV
S
A
S
S
-
IS
DP
I
I
Q
L
IA
SLAL
--
AF
V
L
Y
A
A
S
FPS
V
M
D
SLT
A
G
T
I
T
V
V
F
S
SMI
A
L
MR
PL
KS
LT
NV
-------
N
A
QF
QR
GM
AA
CQTL
F
T
I
L
D
S
E
Q
EK
------
DEGK
R
VIE
R
A
T
G
DVE
FR
NV
T
FTYP
GR
D
V
PAL
R
NINL
K
IP
A
G
KT
VALVG
R
S
GSGKST
I
ASLI
T
R
F
YD
I
D
EGEI
L
M
DG
H
D
L
RE
Y
T
L
A
SLR
NQ
VA
L
VSQ
N
V
H
LF
N
DTVANNIA
YAR
TEQY
S
R
E
Q
IE
E
AAR
M
A
YAM
D
F
I
NK
M
DN
G
L
DT
V
I
GE
N
GV
L
LSGGQ
R
QRIAIARALL
RDSP
ILILDEATSA
L
D
TE
S
E
R
AIQ
A
AL
DELQ
K
N
RT
S
LVIAHRLSTI
E
K
ADEIVV
V
ED
G
V
IVERGTH
ND
LL
ERR
G
V
Y
A
Q
LH
K
M
Q
FG
fig|216593.1.peg.1563
Escherichia coli E2348/69 (11-581/582)
Q
TFRRL
------
W
PTIAPFKA
G
L
IVA
GVAL
-
IL
NA
A
SDTF
ML
S
L
LK
P
----LLD
DG
FGK---
T
DRS
VL
M
W
M
P
LV
V
I
GL
MI
----
L
RG
--
ITS
Y
ISS
Y
CI
S
W
V
SG-
-
--K
VV
MT
M
R
R
R
LFGHMM
GM
P
V
SFFD
K
Q
S
TG
T
L
L
SR
I
T
Y
D
S
E
-------
Q
V
A
SSSSGALI
TVVR
EG
A
SI
I
G
---
L
F
I
MMF
YY
SWQL
-
SI
I
L
I
V
L
A
P
I
VS
I
AI
------
R
VVSK
RFR
NIS
K
NMQ
N
T
MG
QVTT
S
AEQ
M
LK
G
HKE
V
LI
FG
GQEVETKRFDK
VSN
R
MRLQ-----------G
M
K
MV
S
A
S
S
-
IS
DP
I
I
Q
L
IA
SLAL
--
AF
V
L
Y
A
A
S
FPS
V
M
D
SLT
A
G
T
I
T
V
V
F
S
SMI
A
L
MR
PL
KS
LT
NV
-------
N
A
QF
QR
GM
AA
CQTL
F
T
I
L
D
S
E
Q
EK
------
DEGK
R
VIE
R
A
T
G
DVE
FR
NV
T
FTYP
GR
D
V
PAL
R
NINL
K
IP
A
G
KT
VALVG
R
S
GSGKST
I
ASLI
T
R
F
YD
I
D
EGEI
L
M
DG
H
D
L
RE
Y
T
L
A
SLR
NQ
VA
L
VSQ
N
V
H
LF
N
DTVANNIA
YAR
TEQY
S
R
E
Q
IE
E
AAR
M
A
YAM
D
F
I
NK
M
DN
G
L
DT
V
I
GE
N
GV
L
LSGGQ
R
QRIAIARALL
RDSP
ILILDEATSA
L
D
TE
S
E
R
AIQ
A
AL
DELQ
K
N
RT
S
LVIAHRLSTI
E
K
ADEIVV
V
ED
G
V
IVERGTH
ND
LL
ERR
G
V
Y
A
Q
LH
K
M
Q
FG
fig|869729.3.peg.2770
Escherichia coli UM146 (11-581/582)
Q
TFRRL
------
W
PTIAPFKA
G
L
IVA
GVAL
-
IL
NA
A
SDTF
ML
S
L
LK
P
----LLD
DG
FGK---
T
DRS
VL
M
W
M
P
LV
V
I
GL
MI
----
L
RG
--
ITS
Y
ISS
Y
CI
S
W
V
SG-
-
--K
VV
MT
M
R
R
R
LFGHMM
GM
P
V
SFFD
K
Q
S
TG
T
L
L
SR
I
T
Y
D
S
E
-------
Q
V
A
SSSSGALI
TVVR
EG
A
SI
I
G
---
L
F
I
MMF
YY
SWQL
-
SI
I
L
I
V
L
A
P
I
VS
I
AI
------
R
VVSK
RFR
NIS
K
NMQ
N
T
MG
QVTT
S
AEQ
M
LK
G
HKE
V
LI
FG
GQEVETKRFDK
VSN
R
MRLQ-----------G
M
K
MV
S
A
S
S
-
IS
DP
I
I
Q
L
IA
SLAL
--
AF
V
L
Y
A
A
S
FPS
V
M
D
SLT
A
G
T
I
T
V
V
F
S
SMI
A
L
MR
PL
KS
LT
NV
-------
N
A
QF
QR
GM
AA
CQTL
F
T
I
L
D
S
E
Q
EK
------
DEGK
R
VIE
R
A
T
G
DVE
FR
NV
T
FTYP
GR
D
V
PAL
R
NINL
K
IP
A
G
KT
VALVG
R
S
GSGKST
I
ASLI
T
R
F
YD
I
D
EGEI
L
M
DG
H
D
L
RE
Y
T
L
A
SLR
NQ
VA
L
VSQ
N
V
H
LF
N
DTVANNIA
YAR
TEQY
S
R
E
Q
IE
E
AAR
M
A
YAM
D
F
I
NK
M
DN
G
L
DT
V
I
GE
N
GV
L
LSGGQ
R
QRIAIARALL
RDSP
ILILDEATSA
L
D
TE
S
E
R
AIQ
A
AL
DELQ
K
N
RT
S
LVIAHRLSTI
E
K
AD
K
IVV
V
ED
G
V
IVERGTH
ND
LL
EHR
G
V
Y
A
Q
LH
K
M
Q
FG
fig|362663.8.peg.936
Escherichia coli 536 (11-581/582)
Q
TFRRL
------
W
PTIAPFKA
G
L
IVA
GVAL
-
IL
NA
A
SDTF
ML
S
L
LK
P
----LLD
DG
FGK---
T
DRS
VL
M
W
M
P
LV
V
I
GL
MI
----
L
RG
--
ITS
Y
ISS
Y
CI
S
W
V
SG-
-
--K
VV
MT
M
R
R
R
LFGHMM
GM
P
V
SFFD
K
Q
S
TG
T
L
L
SR
I
T
Y
D
S
E
-------
Q
V
A
SSSSGALI
TVVR
EG
A
SI
I
G
---
L
F
I
MMF
YY
SWQL
-
SI
I
L
I
V
L
A
P
I
VS
I
AI
------
R
VVSK
RFR
NIS
K
NMQ
N
T
MG
QVTT
S
AEQ
M
LK
G
HKE
V
LI
FG
GQEVETKRFDK
VSN
R
MRLQ-----------G
M
K
MV
S
A
S
S
-
IS
DP
I
I
Q
L
IA
SLAL
--
AF
V
L
Y
A
A
S
FPS
V
M
D
SLT
A
G
T
I
T
V
V
F
S
SMI
A
L
MR
PL
KS
LT
NV
-------
N
A
QF
QR
GM
AA
CQTL
F
T
I
L
D
S
E
Q
EK
------
DEGK
R
VIE
R
A
T
G
DVE
FR
NV
T
FTYP
GR
D
V
PAL
R
NINL
K
IP
A
G
KT
VALVG
R
S
GSGKST
I
ASLI
T
R
F
YD
I
D
EGEI
L
M
DG
H
D
L
RE
Y
T
L
A
SLR
NQ
VA
L
VSQ
N
V
H
LF
N
DTVANNIA
YAR
TEQY
S
R
E
Q
IE
E
AAR
M
A
YAM
D
F
I
NK
M
DN
G
L
DT
V
I
GE
N
GV
L
LSGGQ
R
QRIAIARALL
RDSP
ILILDEATSA
L
D
TE
S
E
R
AIQ
A
AL
DELQ
K
N
RT
S
LVIAHRLSTI
E
K
ADEIVV
V
ED
G
V
IVERGTH
ND
LL
EHR
G
V
Y
A
Q
LH
K
M
Q
FG
fig|362663.9.peg.936
Escherichia coli 536 (11-581/582)
Q
TFRRL
------
W
PTIAPFKA
G
L
IVA
GVAL
-
IL
NA
A
SDTF
ML
S
L
LK
P
----LLD
DG
FGK---
T
DRS
VL
M
W
M
P
LV
V
I
GL
MI
----
L
RG
--
ITS
Y
ISS
Y
CI
S
W
V
SG-
-
--K
VV
MT
M
R
R
R
LFGHMM
GM
P
V
SFFD
K
Q
S
TG
T
L
L
SR
I
T
Y
D
S
E
-------
Q
V
A
SSSSGALI
TVVR
EG
A
SI
I
G
---
L
F
I
MMF
YY
SWQL
-
SI
I
L
I
V
L
A
P
I
VS
I
AI
------
R
VVSK
RFR
NIS
K
NMQ
N
T
MG
QVTT
S
AEQ
M
LK
G
HKE
V
LI
FG
GQEVETKRFDK
VSN
R
MRLQ-----------G
M
K
MV
S
A
S
S
-
IS
DP
I
I
Q
L
IA
SLAL
--
AF
V
L
Y
A
A
S
FPS
V
M
D
SLT
A
G
T
I
T
V
V
F
S
SMI
A
L
MR
PL
KS
LT
NV
-------
N
A
QF
QR
GM
AA
CQTL
F
T
I
L
D
S
E
Q
EK
------
DEGK
R
VIE
R
A
T
G
DVE
FR
NV
T
FTYP
GR
D
V
PAL
R
NINL
K
IP
A
G
KT
VALVG
R
S
GSGKST
I
ASLI
T
R
F
YD
I
D
EGEI
L
M
DG
H
D
L
RE
Y
T
L
A
SLR
NQ
VA
L
VSQ
N
V
H
LF
N
DTVANNIA
YAR
TEQY
S
R
E
Q
IE
E
AAR
M
A
YAM
D
F
I
NK
M
DN
G
L
DT
V
I
GE
N
GV
L
LSGGQ
R
QRIAIARALL
RDSP
ILILDEATSA
L
D
TE
S
E
R
AIQ
A
AL
DELQ
K
N
RT
S
LVIAHRLSTI
E
K
ADEIVV
V
ED
G
V
IVERGTH
ND
LL
EHR
G
V
Y
A
Q
LH
K
M
Q
FG
fig|525281.3.peg.2038
Escherichia coli 83972 (11-581/582)
Q
TFRRL
------
W
PTIAPFKA
G
L
IVA
GVAL
-
IL
NA
A
SDTF
ML
S
L
LK
P
----LLD
DG
FGK---
T
DRS
VL
M
W
M
P
LV
V
I
GL
MI
----
L
RG
--
ITS
Y
ISS
Y
CI
S
W
V
SG-
-
--K
VV
MT
M
R
R
R
LFGHMM
GM
P
V
SFFD
K
Q
S
TG
T
L
L
SR
I
T
Y
D
S
E
-------
Q
V
A
SSSSGALI
TVVR
EG
A
SI
I
G
---
L
F
I
MMF
YY
SWQL
-
SI
I
L
I
V
L
A
P
I
VS
I
AI
------
R
VVSK
RFR
NIS
K
NMQ
N
T
MG
QVTT
S
AEQ
M
LK
G
HKE
V
LI
FG
GQEVETKRFDK
VSN
R
MRLQ-----------G
M
K
MV
S
A
S
S
-
IS
DP
I
I
Q
L
IA
SLAL
--
AF
V
L
Y
A
A
S
FPS
V
M
D
SLT
A
G
T
I
T
V
V
F
S
SMI
A
L
MR
PL
KS
LT
NV
-------
N
A
QF
QR
GM
AA
CQTL
F
T
I
L
D
S
E
Q
EK
------
DEGK
R
VIE
R
A
T
G
DVE
FR
NV
T
FTYP
GR
D
V
PAL
R
NINL
K
IP
A
G
KT
VALVG
R
S
GSGKST
I
ASLI
T
R
F
YD
I
D
EGEI
L
M
DG
H
D
L
RE
Y
T
L
A
SLR
NQ
VA
L
VSQ
N
V
H
LF
N
DTVANNIA
YAR
TEQY
S
R
E
Q
IE
E
AAR
M
A
YAM
D
F
I
NK
M
DN
G
L
DT
V
I
GE
N
GV
L
LSGGQ
R
QRIAIARALL
RDSP
ILILDEATSA
L
D
TE
S
E
R
AIQ
A
AL
DELQ
K
N
RT
S
LVIAHRLSTI
E
K
ADEIVV
V
ED
G
V
IVERGTH
ND
LL
EHR
G
V
Y
A
Q
LH
K
M
Q
FG
fig|655817.3.peg.1005
Escherichia coli ABU 83972 (11-581/582)
Q
TFRRL
------
W
PTIAPFKA
G
L
IVA
GVAL
-
IL
NA
A
SDTF
ML
S
L
LK
P
----LLD
DG
FGK---
T
DRS
VL
M
W
M
P
LV
V
I
GL
MI
----
L
RG
--
ITS
Y
ISS
Y
CI
S
W
V
SG-
-
--K
VV
MT
M
R
R
R
LFGHMM
GM
P
V
SFFD
K
Q
S
TG
T
L
L
SR
I
T
Y
D
S
E
-------
Q
V
A
SSSSGALI
TVVR
EG
A
SI
I
G
---
L
F
I
MMF
YY
SWQL
-
SI
I
L
I
V
L
A
P
I
VS
I
AI
------
R
VVSK
RFR
NIS
K
NMQ
N
T
MG
QVTT
S
AEQ
M
LK
G
HKE
V
LI
FG
GQEVETKRFDK
VSN
R
MRLQ-----------G
M
K
MV
S
A
S
S
-
IS
DP
I
I
Q
L
IA
SLAL
--
AF
V
L
Y
A
A
S
FPS
V
M
D
SLT
A
G
T
I
T
V
V
F
S
SMI
A
L
MR
PL
KS
LT
NV
-------
N
A
QF
QR
GM
AA
CQTL
F
T
I
L
D
S
E
Q
EK
------
DEGK
R
VIE
R
A
T
G
DVE
FR
NV
T
FTYP
GR
D
V
PAL
R
NINL
K
IP
A
G
KT
VALVG
R
S
GSGKST
I
ASLI
T
R
F
YD
I
D
EGEI
L
M
DG
H
D
L
RE
Y
T
L
A
SLR
NQ
VA
L
VSQ
N
V
H
LF
N
DTVANNIA
YAR
TEQY
S
R
E
Q
IE
E
AAR
M
A
YAM
D
F
I
NK
M
DN
G
L
DT
V
I
GE
N
GV
L
LSGGQ
R
QRIAIARALL
RDSP
ILILDEATSA
L
D
TE
S
E
R
AIQ
A
AL
DELQ
K
N
RT
S
LVIAHRLSTI
E
K
ADEIVV
V
ED
G
V
IVERGTH
ND
LL
EHR
G
V
Y
A
Q
LH
K
M
Q
FG
fig|405955.13.peg.929
Escherichia coli APEC O1 (11-581/582)
Q
TFRRL
------
W
PTIAPFKA
G
L
IVA
GVAL
-
IL
NA
A
SDTF
ML
S
L
LK
P
----LLD
DG
FGK---
T
DRS
VL
M
W
M
P
LV
V
I
GL
MI
----
L
RG
--
ITS
Y
ISS
Y
CI
S
W
V
SG-
-
--K
VV
MT
M
R
R
R
LFGHMM
GM
P
V
SFFD
K
Q
S
TG
T
L
L
SR
I
T
Y
D
S
E
-------
Q
V
A
SSSSGALI
TVVR
EG
A
SI
I
G
---
L
F
I
MMF
YY
SWQL
-
SI
I
L
I
V
L
A
P
I
VS
I
AI
------
R
VVSK
RFR
NIS
K
NMQ
N
T
MG
QVTT
S
AEQ
M
LK
G
HKE
V
LI
FG
GQEVETKRFDK
VSN
R
MRLQ-----------G
M
K
MV
S
A
S
S
-
IS
DP
I
I
Q
L
IA
SLAL
--
AF
V
L
Y
A
A
S
FPS
V
M
D
SLT
A
G
T
I
T
V
V
F
S
SMI
A
L
MR
PL
KS
LT
NV
-------
N
A
QF
QR
GM
AA
CQTL
F
T
I
L
D
S
E
Q
EK
------
DEGK
R
VIE
R
A
T
G
DVE
FR
NV
T
FTYP
GR
D
V
PAL
R
NINL
K
IP
A
G
KT
VALVG
R
S
GSGKST
I
ASLI
T
R
F
YD
I
D
EGEI
L
M
DG
H
D
L
RE
Y
T
L
A
SLR
NQ
VA
L
VSQ
N
V
H
LF
N
DTVANNIA
YAR
TEQY
S
R
E
Q
IE
E
AAR
M
A
YAM
D
F
I
NK
M
DN
G
L
DT
V
I
GE
N
GV
L
LSGGQ
R
QRIAIARALL
RDSP
ILILDEATSA
L
D
TE
S
E
R
AIQ
A
AL
DELQ
K
N
RT
S
LVIAHRLSTI
E
K
ADEIVV
V
ED
G
V
IVERGTH
ND
LL
EHR
G
V
Y
A
Q
LH
K
M
Q
FG
fig|405955.9.peg.778
Escherichia coli APEC O1 (11-581/582)
Q
TFRRL
------
W
PTIAPFKA
G
L
IVA
GVAL
-
IL
NA
A
SDTF
ML
S
L
LK
P
----LLD
DG
FGK---
T
DRS
VL
M
W
M
P
LV
V
I
GL
MI
----
L
RG
--
ITS
Y
ISS
Y
CI
S
W
V
SG-
-
--K
VV
MT
M
R
R
R
LFGHMM
GM
P
V
SFFD
K
Q
S
TG
T
L
L
SR
I
T
Y
D
S
E
-------
Q
V
A
SSSSGALI
TVVR
EG
A
SI
I
G
---
L
F
I
MMF
YY
SWQL
-
SI
I
L
I
V
L
A
P
I
VS
I
AI
------
R
VVSK
RFR
NIS
K
NMQ
N
T
MG
QVTT
S
AEQ
M
LK
G
HKE
V
LI
FG
GQEVETKRFDK
VSN
R
MRLQ-----------G
M
K
MV
S
A
S
S
-
IS
DP
I
I
Q
L
IA
SLAL
--
AF
V
L
Y
A
A
S
FPS
V
M
D
SLT
A
G
T
I
T
V
V
F
S
SMI
A
L
MR
PL
KS
LT
NV
-------
N
A
QF
QR
GM
AA
CQTL
F
T
I
L
D
S
E
Q
EK
------
DEGK
R
VIE
R
A
T
G
DVE
FR
NV
T
FTYP
GR
D
V
PAL
R
NINL
K
IP
A
G
KT
VALVG
R
S
GSGKST
I
ASLI
T
R
F
YD
I
D
EGEI
L
M
DG
H
D
L
RE
Y
T
L
A
SLR
NQ
VA
L
VSQ
N
V
H
LF
N
DTVANNIA
YAR
TEQY
S
R
E
Q
IE
E
AAR
M
A
YAM
D
F
I
NK
M
DN
G
L
DT
V
I
GE
N
GV
L
LSGGQ
R
QRIAIARALL
RDSP
ILILDEATSA
L
D
TE
S
E
R
AIQ
A
AL
DELQ
K
N
RT
S
LVIAHRLSTI
E
K
ADEIVV
V
ED
G
V
IVERGTH
ND
LL
EHR
G
V
Y
A
Q
LH
K
M
Q
FG
fig|199310.1.peg.1024
Escherichia coli CFT073 (11-581/582)
Q
TFRRL
------
W
PTIAPFKA
G
L
IVA
GVAL
-
IL
NA
A
SDTF
ML
S
L
LK
P
----LLD
DG
FGK---
T
DRS
VL
M
W
M
P
LV
V
I
GL
MI
----
L
RG
--
ITS
Y
ISS
Y
CI
S
W
V
SG-
-
--K
VV
MT
M
R
R
R
LFGHMM
GM
P
V
SFFD
K
Q
S
TG
T
L
L
SR
I
T
Y
D
S
E
-------
Q
V
A
SSSSGALI
TVVR
EG
A
SI
I
G
---
L
F
I
MMF
YY
SWQL
-
SI
I
L
I
V
L
A
P
I
VS
I
AI
------
R
VVSK
RFR
NIS
K
NMQ
N
T
MG
QVTT
S
AEQ
M
LK
G
HKE
V
LI
FG
GQEVETKRFDK
VSN
R
MRLQ-----------G
M
K
MV
S
A
S
S
-
IS
DP
I
I
Q
L
IA
SLAL
--
AF
V
L
Y
A
A
S
FPS
V
M
D
SLT
A
G
T
I
T
V
V
F
S
SMI
A
L
MR
PL
KS
LT
NV
-------
N
A
QF
QR
GM
AA
CQTL
F
T
I
L
D
S
E
Q
EK
------
DEGK
R
VIE
R
A
T
G
DVE
FR
NV
T
FTYP
GR
D
V
PAL
R
NINL
K
IP
A
G
KT
VALVG
R
S
GSGKST
I
ASLI
T
R
F
YD
I
D
EGEI
L
M
DG
H
D
L
RE
Y
T
L
A
SLR
NQ
VA
L
VSQ
N
V
H
LF
N
DTVANNIA
YAR
TEQY
S
R
E
Q
IE
E
AAR
M
A
YAM
D
F
I
NK
M
DN
G
L
DT
V
I
GE
N
GV
L
LSGGQ
R
QRIAIARALL
RDSP
ILILDEATSA
L
D
TE
S
E
R
AIQ
A
AL
DELQ
K
N
RT
S
LVIAHRLSTI
E
K
ADEIVV
V
ED
G
V
IVERGTH
ND
LL
EHR
G
V
Y
A
Q
LH
K
M
Q
FG
fig|199310.4.peg.1001
Escherichia coli CFT073 (11-581/582)
Q
TFRRL
------
W
PTIAPFKA
G
L
IVA
GVAL
-
IL
NA
A
SDTF
ML
S
L
LK
P
----LLD
DG
FGK---
T
DRS
VL
M
W
M
P
LV
V
I
GL
MI
----
L
RG
--
ITS
Y
ISS
Y
CI
S
W
V
SG-
-
--K
VV
MT
M
R
R
R
LFGHMM
GM
P
V
SFFD
K
Q
S
TG
T
L
L
SR
I
T
Y
D
S
E
-------
Q
V
A
SSSSGALI
TVVR
EG
A
SI
I
G
---
L
F
I
MMF
YY
SWQL
-
SI
I
L
I
V
L
A
P
I
VS
I
AI
------
R
VVSK
RFR
NIS
K
NMQ
N
T
MG
QVTT
S
AEQ
M
LK
G
HKE
V
LI
FG
GQEVETKRFDK
VSN
R
MRLQ-----------G
M
K
MV
S
A
S
S
-
IS
DP
I
I
Q
L
IA
SLAL
--
AF
V
L
Y
A
A
S
FPS
V
M
D
SLT
A
G
T
I
T
V
V
F
S
SMI
A
L
MR
PL
KS
LT
NV
-------
N
A
QF
QR
GM
AA
CQTL
F
T
I
L
D
S
E
Q
EK
------
DEGK
R
VIE
R
A
T
G
DVE
FR
NV
T
FTYP
GR
D
V
PAL
R
NINL
K
IP
A
G
KT
VALVG
R
S
GSGKST
I
ASLI
T
R
F
YD
I
D
EGEI
L
M
DG
H
D
L
RE
Y
T
L
A
SLR
NQ
VA
L
VSQ
N
V
H
LF
N
DTVANNIA
YAR
TEQY
S
R
E
Q
IE
E
AAR
M
A
YAM
D
F
I
NK
M
DN
G
L
DT
V
I
GE
N
GV
L
LSGGQ
R
QRIAIARALL
RDSP
ILILDEATSA
L
D
TE
S
E
R
AIQ
A
AL
DELQ
K
N
RT
S
LVIAHRLSTI
E
K
ADEIVV
V
ED
G
V
IVERGTH
ND
LL
EHR
G
V
Y
A
Q
LH
K
M
Q
FG
fig|585397.7.peg.950
Escherichia coli ED1a (11-581/582)
Q
TFRRL
------
W
PTIAPFKA
G
L
IVA
GVAL
-
IL
NA
A
SDTF
ML
S
L
LK
P
----LLD
DG
FGK---
T
DRS
VL
M
W
M
P
LV
V
I
GL
MI
----
L
RG
--
ITS
Y
ISS
Y
CI
S
W
V
SG-
-
--K
VV
MT
M
R
R
R
LFGHMM
GM
P
V
SFFD
K
Q
S
TG
T
L
L
SR
I
T
Y
D
S
E
-------
Q
V
A
SSSSGALI
TVVR
EG
A
SI
I
G
---
L
F
I
MMF
YY
SWQL
-
SI
I
L
I
V
L
A
P
I
VS
I
AI
------
R
VVSK
RFR
NIS
K
NMQ
N
T
MG
QVTT
S
AEQ
M
LK
G
HKE
V
LI
FG
GQEVETKRFDK
VSN
R
MRLQ-----------G
M
K
MV
S
A
S
S
-
IS
DP
I
I
Q
L
IA
SLAL
--
AF
V
L
Y
A
A
S
FPS
V
M
D
SLT
A
G
T
I
T
V
V
F
S
SMI
A
L
MR
PL
KS
LT
NV
-------
N
A
QF
QR
GM
AA
CQTL
F
T
I
L
D
S
E
Q
EK
------
DEGK
R
VIE
R
A
T
G
DVE
FR
NV
T
FTYP
GR
D
V
PAL
R
NINL
K
IP
A
G
KT
VALVG
R
S
GSGKST
I
ASLI
T
R
F
YD
I
D
EGEI
L
M
DG
H
D
L
RE
Y
T
L
A
SLR
NQ
VA
L
VSQ
N
V
H
LF
N
DTVANNIA
YAR
TEQY
S
R
E
Q
IE
E
AAR
M
A
YAM
D
F
I
NK
M
DN
G
L
DT
V
I
GE
N
GV
L
LSGGQ
R
QRIAIARALL
RDSP
ILILDEATSA
L
D
TE
S
E
R
AIQ
A
AL
DELQ
K
N
RT
S
LVIAHRLSTI
E
K
ADEIVV
V
ED
G
V
IVERGTH
ND
LL
EHR
G
V
Y
A
Q
LH
K
M
Q
FG
fig|585397.9.peg.950
Escherichia coli ED1a (11-581/582)
Q
TFRRL
------
W
PTIAPFKA
G
L
IVA
GVAL
-
IL
NA
A
SDTF
ML
S
L
LK
P
----LLD
DG
FGK---
T
DRS
VL
M
W
M
P
LV
V
I
GL
MI
----
L
RG
--
ITS
Y
ISS
Y
CI
S
W
V
SG-
-
--K
VV
MT
M
R
R
R
LFGHMM
GM
P
V
SFFD
K
Q
S
TG
T
L
L
SR
I
T
Y
D
S
E
-------
Q
V
A
SSSSGALI
TVVR
EG
A
SI
I
G
---
L
F
I
MMF
YY
SWQL
-
SI
I
L
I
V
L
A
P
I
VS
I
AI
------
R
VVSK
RFR
NIS
K
NMQ
N
T
MG
QVTT
S
AEQ
M
LK
G
HKE
V
LI
FG
GQEVETKRFDK
VSN
R
MRLQ-----------G
M
K
MV
S
A
S
S
-
IS
DP
I
I
Q
L
IA
SLAL
--
AF
V
L
Y
A
A
S
FPS
V
M
D
SLT
A
G
T
I
T
V
V
F
S
SMI
A
L
MR
PL
KS
LT
NV
-------
N
A
QF
QR
GM
AA
CQTL
F
T
I
L
D
S
E
Q
EK
------
DEGK
R
VIE
R
A
T
G
DVE
FR
NV
T
FTYP
GR
D
V
PAL
R
NINL
K
IP
A
G
KT
VALVG
R
S
GSGKST
I
ASLI
T
R
F
YD
I
D
EGEI
L
M
DG
H
D
L
RE
Y
T
L
A
SLR
NQ
VA
L
VSQ
N
V
H
LF
N
DTVANNIA
YAR
TEQY
S
R
E
Q
IE
E
AAR
M
A
YAM
D
F
I
NK
M
DN
G
L
DT
V
I
GE
N
GV
L
LSGGQ
R
QRIAIARALL
RDSP
ILILDEATSA
L
D
TE
S
E
R
AIQ
A
AL
DELQ
K
N
RT
S
LVIAHRLSTI
E
K
ADEIVV
V
ED
G
V
IVERGTH
ND
LL
EHR
G
V
Y
A
Q
LH
K
M
Q
FG
fig|340197.3.peg.2219
Escherichia coli F11 (11-581/582)
Q
TFRRL
------
W
PTIAPFKA
G
L
IVA
GVAL
-
IL
NA
A
SDTF
ML
S
L
LK
P
----LLD
DG
FGK---
T
DRS
VL
M
W
M
P
LV
V
I
GL
MI
----
L
RG
--
ITS
Y
ISS
Y
CI
S
W
V
SG-
-
--K
VV
MT
M
R
R
R
LFGHMM
GM
P
V
SFFD
K
Q
S
TG
T
L
L
SR
I
T
Y
D
S
E
-------
Q
V
A
SSSSGALI
TVVR
EG
A
SI
I
G
---
L
F
I
MMF
YY
SWQL
-
SI
I
L
I
V
L
A
P
I
VS
I
AI
------
R
VVSK
RFR
NIS
K
NMQ
N
T
MG
QVTT
S
AEQ
M
LK
G
HKE
V
LI
FG
GQEVETKRFDK
VSN
R
MRLQ-----------G
M
K
MV
S
A
S
S
-
IS
DP
I
I
Q
L
IA
SLAL
--
AF
V
L
Y
A
A
S
FPS
V
M
D
SLT
A
G
T
I
T
V
V
F
S
SMI
A
L
MR
PL
KS
LT
NV
-------
N
A
QF
QR
GM
AA
CQTL
F
T
I
L
D
S
E
Q
EK
------
DEGK
R
VIE
R
A
T
G
DVE
FR
NV
T
FTYP
GR
D
V
PAL
R
NINL
K
IP
A
G
KT
VALVG
R
S
GSGKST
I
ASLI
T
R
F
YD
I
D
EGEI
L
M
DG
H
D
L
RE
Y
T
L
A
SLR
NQ
VA
L
VSQ
N
V
H
LF
N
DTVANNIA
YAR
TEQY
S
R
E
Q
IE
E
AAR
M
A
YAM
D
F
I
NK
M
DN
G
L
DT
V
I
GE
N
GV
L
LSGGQ
R
QRIAIARALL
RDSP
ILILDEATSA
L
D
TE
S
E
R
AIQ
A
AL
DELQ
K
N
RT
S
LVIAHRLSTI
E
K
ADEIVV
V
ED
G
V
IVERGTH
ND
LL
EHR
G
V
Y
A
Q
LH
K
M
Q
FG
fig|340197.5.peg.2333
Escherichia coli F11 (11-581/582)
Q
TFRRL
------
W
PTIAPFKA
G
L
IVA
GVAL
-
IL
NA
A
SDTF
ML
S
L
LK
P
----LLD
DG
FGK---
T
DRS
VL
M
W
M
P
LV
V
I
GL
MI
----
L
RG
--
ITS
Y
ISS
Y
CI
S
W
V
SG-
-
--K
VV
MT
M
R
R
R
LFGHMM
GM
P
V
SFFD
K
Q
S
TG
T
L
L
SR
I
T
Y
D
S
E
-------
Q
V
A
SSSSGALI
TVVR
EG
A
SI
I
G
---
L
F
I
MMF
YY
SWQL
-
SI
I
L
I
V
L
A
P
I
VS
I
AI
------
R
VVSK
RFR
NIS
K
NMQ
N
T
MG
QVTT
S
AEQ
M
LK
G
HKE
V
LI
FG
GQEVETKRFDK
VSN
R
MRLQ-----------G
M
K
MV
S
A
S
S
-
IS
DP
I
I
Q
L
IA
SLAL
--
AF
V
L
Y
A
A
S
FPS
V
M
D
SLT
A
G
T
I
T
V
V
F
S
SMI
A
L
MR
PL
KS
LT
NV
-------
N
A
QF
QR
GM
AA
CQTL
F
T
I
L
D
S
E
Q
EK
------
DEGK
R
VIE
R
A
T
G
DVE
FR
NV
T
FTYP
GR
D
V
PAL
R
NINL
K
IP
A
G
KT
VALVG
R
S
GSGKST
I
ASLI
T
R
F
YD
I
D
EGEI
L
M
DG
H
D
L
RE
Y
T
L
A
SLR
NQ
VA
L
VSQ
N
V
H
LF
N
DTVANNIA
YAR
TEQY
S
R
E
Q
IE
E
AAR
M
A
YAM
D
F
I
NK
M
DN
G
L
DT
V
I
GE
N
GV
L
LSGGQ
R
QRIAIARALL
RDSP
ILILDEATSA
L
D
TE
S
E
R
AIQ
A
AL
DELQ
K
N
RT
S
LVIAHRLSTI
E
K
ADEIVV
V
ED
G
V
IVERGTH
ND
LL
EHR
G
V
Y
A
Q
LH
K
M
Q
FG
fig|656393.3.peg.1678
Escherichia coli H299 (11-581/582)
Q
TFRRL
------
W
PTIAPFKA
G
L
IVA
GVAL
-
IL
NA
A
SDTF
ML
S
L
LK
P
----LLD
DG
FGK---
T
DRS
VL
M
W
M
P
LV
V
I
GL
MI
----
L
RG
--
ITS
Y
ISS
Y
CI
S
W
V
SG-
-
--K
VV
MT
M
R
R
R
LFGHMM
GM
P
V
SFFD
K
Q
S
TG
T
L
L
SR
I
T
Y
D
S
E
-------
Q
V
A
SSSSGALI
TVVR
EG
A
SI
I
G
---
L
F
I
MMF
YY
SWQL
-
SI
I
L
I
V
L
A
P
I
VS
I
AI
------
R
VVSK
RFR
NIS
K
NMQ
N
T
MG
QVTT
S
AEQ
M
LK
G
HKE
V
LI
FG
GQEVETKRFDK
VSN
R
MRLQ-----------G
M
K
MV
S
A
S
S
-
IS
DP
I
I
Q
L
IA
SLAL
--
AF
V
L
Y
A
A
S
FPS
V
M
D
SLT
A
G
T
I
T
V
V
F
S
SMI
A
L
MR
PL
KS
LT
NV
-------
N
A
QF
QR
GM
AA
CQTL
F
T
I
L
D
S
E
Q
EK
------
DEGK
R
VIE
R
A
T
G
DVE
FR
NV
T
FTYP
GR
D
V
PAL
R
NINL
K
IP
A
G
KT
VALVG
R
S
GSGKST
I
ASLI
T
R
F
YD
I
D
EGEI
L
M
DG
H
D
L
RE
Y
T
L
A
SLR
NQ
VA
L
VSQ
N
V
H
LF
N
DTVANNIA
YAR
TEQY
S
R
E
Q
IE
E
AAR
M
A
YAM
D
F
I
NK
M
DN
G
L
DT
V
I
GE
N
GV
L
LSGGQ
R
QRIAIARALL
RDSP
ILILDEATSA
L
D
TE
S
E
R
AIQ
A
AL
DELQ
K
N
RT
S
LVIAHRLSTI
E
K
ADEIVV
V
ED
G
V
IVERGTH
ND
LL
EHR
G
V
Y
A
Q
LH
K
M
Q
FG
fig|714962.3.peg.990
Escherichia coli IHE3034 (11-581/582)
Q
TFRRL
------
W
PTIAPFKA
G
L
IVA
GVAL
-
IL
NA
A
SDTF
ML
S
L
LK
P
----LLD
DG
FGK---
T
DRS
VL
M
W
M
P
LV
V
I
GL
MI
----
L
RG
--
ITS
Y
ISS
Y
CI
S
W
V
SG-
-
--K
VV
MT
M
R
R
R
LFGHMM
GM
P
V
SFFD
K
Q
S
TG
T
L
L
SR
I
T
Y
D
S
E
-------
Q
V
A
SSSSGALI
TVVR
EG
A
SI
I
G
---
L
F
I
MMF
YY
SWQL
-
SI
I
L
I
V
L
A
P
I
VS
I
AI
------
R
VVSK
RFR
NIS
K
NMQ
N
T
MG
QVTT
S
AEQ
M
LK
G
HKE
V
LI
FG
GQEVETKRFDK
VSN
R
MRLQ-----------G
M
K
MV
S
A
S
S
-
IS
DP
I
I
Q
L
IA
SLAL
--
AF
V
L
Y
A
A
S
FPS
V
M
D
SLT
A
G
T
I
T
V
V
F
S
SMI
A
L
MR
PL
KS
LT
NV
-------
N
A
QF
QR
GM
AA
CQTL
F
T
I
L
D
S
E
Q
EK
------
DEGK
R
VIE
R
A
T
G
DVE
FR
NV
T
FTYP
GR
D
V
PAL
R
NINL
K
IP
A
G
KT
VALVG
R
S
GSGKST
I
ASLI
T
R
F
YD
I
D
EGEI
L
M
DG
H
D
L
RE
Y
T
L
A
SLR
NQ
VA
L
VSQ
N
V
H
LF
N
DTVANNIA
YAR
TEQY
S
R
E
Q
IE
E
AAR
M
A
YAM
D
F
I
NK
M
DN
G
L
DT
V
I
GE
N
GV
L
LSGGQ
R
QRIAIARALL
RDSP
ILILDEATSA
L
D
TE
S
E
R
AIQ
A
AL
DELQ
K
N
RT
S
LVIAHRLSTI
E
K
ADEIVV
V
ED
G
V
IVERGTH
ND
LL
EHR
G
V
Y
A
Q
LH
K
M
Q
FG
fig|656417.3.peg.1154
Escherichia coli M605 (11-581/582)
Q
TFRRL
------
W
PTIAPFKA
G
L
IVA
GVAL
-
IL
NA
A
SDTF
ML
S
L
LK
P
----LLD
DG
FGK---
T
DRS
VL
M
W
M
P
LV
V
I
GL
MI
----
L
RG
--
ITS
Y
ISS
Y
CI
S
W
V
SG-
-
--K
VV
MT
M
R
R
R
LFGHMM
GM
P
V
SFFD
K
Q
S
TG
T
L
L
SR
I
T
Y
D
S
E
-------
Q
V
A
SSSSGALI
TVVR
EG
A
SI
I
G
---
L
F
I
MMF
YY
SWQL
-
SI
I
L
I
V
L
A
P
I
VS
I
AI
------
R
VVSK
RFR
NIS
K
NMQ
N
T
MG
QVTT
S
AEQ
M
LK
G
HKE
V
LI
FG
GQEVETKRFDK
VSN
R
MRLQ-----------G
M
K
MV
S
A
S
S
-
IS
DP
I
I
Q
L
IA
SLAL
--
AF
V
L
Y
A
A
S
FPS
V
M
D
SLT
A
G
T
I
T
V
V
F
S
SMI
A
L
MR
PL
KS
LT
NV
-------
N
A
QF
QR
GM
AA
CQTL
F
T
I
L
D
S
E
Q
EK
------
DEGK
R
VIE
R
A
T
G
DVE
FR
NV
T
FTYP
GR
D
V
PAL
R
NINL
K
IP
A
G
KT
VALVG
R
S
GSGKST
I
ASLI
T
R
F
YD
I
D
EGEI
L
M
DG
H
D
L
RE
Y
T
L
A
SLR
NQ
VA
L
VSQ
N
V
H
LF
N
DTVANNIA
YAR
TEQY
S
R
E
Q
IE
E
AAR
M
A
YAM
D
F
I
NK
M
DN
G
L
DT
V
I
GE
N
GV
L
LSGGQ
R
QRIAIARALL
RDSP
ILILDEATSA
L
D
TE
S
E
R
AIQ
A
AL
DELQ
K
N
RT
S
LVIAHRLSTI
E
K
ADEIVV
V
ED
G
V
IVERGTH
ND
LL
EHR
G
V
Y
A
Q
LH
K
M
Q
FG
fig|749546.3.peg.1766
Escherichia coli MS 185-1 (11-581/582)
Q
TFRRL
------
W
PTIAPFKA
G
L
IVA
GVAL
-
IL
NA
A
SDTF
ML
S
L
LK
P
----LLD
DG
FGK---
T
DRS
VL
M
W
M
P
LV
V
I
GL
MI
----
L
RG
--
ITS
Y
ISS
Y
CI
S
W
V
SG-
-
--K
VV
MT
M
R
R
R
LFGHMM
GM
P
V
SFFD
K
Q
S
TG
T
L
L
SR
I
T
Y
D
S
E
-------
Q
V
A
SSSSGALI
TVVR
EG
A
SI
I
G
---
L
F
I
MMF
YY
SWQL
-
SI
I
L
I
V
L
A
P
I
VS
I
AI
------
R
VVSK
RFR
NIS
K
NMQ
N
T
MG
QVTT
S
AEQ
M
LK
G
HKE
V
LI
FG
GQEVETKRFDK
VSN
R
MRLQ-----------G
M
K
MV
S
A
S
S
-
IS
DP
I
I
Q
L
IA
SLAL
--
AF
V
L
Y
A
A
S
FPS
V
M
D
SLT
A
G
T
I
T
V
V
F
S
SMI
A
L
MR
PL
KS
LT
NV
-------
N
A
QF
QR
GM
AA
CQTL
F
T
I
L
D
S
E
Q
EK
------
DEGK
R
VIE
R
A
T
G
DVE
FR
NV
T
FTYP
GR
D
V
PAL
R
NINL
K
IP
A
G
KT
VALVG
R
S
GSGKST
I
ASLI
T
R
F
YD
I
D
EGEI
L
M
DG
H
D
L
RE
Y
T
L
A
SLR
NQ
VA
L
VSQ
N
V
H
LF
N
DTVANNIA
YAR
TEQY
S
R
E
Q
IE
E
AAR
M
A
YAM
D
F
I
NK
M
DN
G
L
DT
V
I
GE
N
GV
L
LSGGQ
R
QRIAIARALL
RDSP
ILILDEATSA
L
D
TE
S
E
R
AIQ
A
AL
DELQ
K
N
RT
S
LVIAHRLSTI
E
K
ADEIVV
V
ED
G
V
IVERGTH
ND
LL
EHR
G
V
Y
A
Q
LH
K
M
Q
FG
fig|749550.3.peg.2110
Escherichia coli MS 200-1 (11-581/582)
Q
TFRRL
------
W
PTIAPFKA
G
L
IVA
GVAL
-
IL
NA
A
SDTF
ML
S
L
LK
P
----LLD
DG
FGK---
T
DRS
VL
M
W
M
P
LV
V
I
GL
MI
----
L
RG
--
ITS
Y
ISS
Y
CI
S
W
V
SG-
-
--K
VV
MT
M
R
R
R
LFGHMM
GM
P
V
SFFD
K
Q
S
TG
T
L
L
SR
I
T
Y
D
S
E
-------
Q
V
A
SSSSGALI
TVVR
EG
A
SI
I
G
---
L
F
I
MMF
YY
SWQL
-
SI
I
L
I
V
L
A
P
I
VS
I
AI
------
R
VVSK
RFR
NIS
K
NMQ
N
T
MG
QVTT
S
AEQ
M
LK
G
HKE
V
LI
FG
GQEVETKRFDK
VSN
R
MRLQ-----------G
M
K
MV
S
A
S
S
-
IS
DP
I
I
Q
L
IA
SLAL
--
AF
V
L
Y
A
A
S
FPS
V
M
D
SLT
A
G
T
I
T
V
V
F
S
SMI
A
L
MR
PL
KS
LT
NV
-------
N
A
QF
QR
GM
AA
CQTL
F
T
I
L
D
S
E
Q
EK
------
DEGK
R
VIE
R
A
T
G
DVE
FR
NV
T
FTYP
GR
D
V
PAL
R
NINL
K
IP
A
G
KT
VALVG
R
S
GSGKST
I
ASLI
T
R
F
YD
I
D
EGEI
L
M
DG
H
D
L
RE
Y
T
L
A
SLR
NQ
VA
L
VSQ
N
V
H
LF
N
DTVANNIA
YAR
TEQY
S
R
E
Q
IE
E
AAR
M
A
YAM
D
F
I
NK
M
DN
G
L
DT
V
I
GE
N
GV
L
LSGGQ
R
QRIAIARALL
RDSP
ILILDEATSA
L
D
TE
S
E
R
AIQ
A
AL
DELQ
K
N
RT
S
LVIAHRLSTI
E
K
ADEIVV
V
ED
G
V
IVERGTH
ND
LL
EHR
G
V
Y
A
Q
LH
K
M
Q
FG
fig|749528.3.peg.1691
Escherichia coli MS 45-1 (11-581/582)
Q
TFRRL
------
W
PTIAPFKA
G
L
IVA
GVAL
-
IL
NA
A
SDTF
ML
S
L
LK
P
----LLD
DG
FGK---
T
DRS
VL
M
W
M
P
LV
V
I
GL
MI
----
L
RG
--
ITS
Y
ISS
Y
CI
S
W
V
SG-
-
--K
VV
MT
M
R
R
R
LFGHMM
GM
P
V
SFFD
K
Q
S
TG
T
L
L
SR
I
T
Y
D
S
E
-------
Q
V
A
SSSSGALI
TVVR
EG
A
SI
I
G
---
L
F
I
MMF
YY
SWQL
-
SI
I
L
I
V
L
A
P
I
VS
I
AI
------
R
VVSK
RFR
NIS
K
NMQ
N
T
MG
QVTT
S
AEQ
M
LK
G
HKE
V
LI
FG
GQEVETKRFDK
VSN
R
MRLQ-----------G
M
K
MV
S
A
S
S
-
IS
DP
I
I
Q
L
IA
SLAL
--
AF
V
L
Y
A
A
S
FPS
V
M
D
SLT
A
G
T
I
T
V
V
F
S
SMI
A
L
MR
PL
KS
LT
NV
-------
N
A
QF
QR
GM
AA
CQTL
F
T
I
L
D
S
E
Q
EK
------
DEGK
R
VIE
R
A
T
G
DVE
FR
NV
T
FTYP
GR
D
V
PAL
R
NINL
K
IP
A
G
KT
VALVG
R
S
GSGKST
I
ASLI
T
R
F
YD
I
D
EGEI
L
M
DG
H
D
L
RE
Y
T
L
A
SLR
NQ
VA
L
VSQ
N
V
H
LF
N
DTVANNIA
YAR
TEQY
S
R
E
Q
IE
E
AAR
M
A
YAM
D
F
I
NK
M
DN
G
L
DT
V
I
GE
N
GV
L
LSGGQ
R
QRIAIARALL
RDSP
ILILDEATSA
L
D
TE
S
E
R
AIQ
A
AL
DELQ
K
N
RT
S
LVIAHRLSTI
E
K
ADEIVV
V
ED
G
V
IVERGTH
ND
LL
EHR
G
V
Y
A
Q
LH
K
M
Q
FG
fig|753642.3.peg.690
Escherichia coli NC101 (11-581/582)
Q
TFRRL
------
W
PTIAPFKA
G
L
IVA
GVAL
-
IL
NA
A
SDTF
ML
S
L
LK
P
----LLD
DG
FGK---
T
DRS
VL
M
W
M
P
LV
V
I
GL
MI
----
L
RG
--
ITS
Y
ISS
Y
CI
S
W
V
SG-
-
--K
VV
MT
M
R
R
R
LFGHMM
GM
P
V
SFFD
K
Q
S
TG
T
L
L
SR
I
T
Y
D
S
E
-------
Q
V
A
SSSSGALI
TVVR
EG
A
SI
I
G
---
L
F
I
MMF
YY
SWQL
-
SI
I
L
I
V
L
A
P
I
VS
I
AI
------
R
VVSK
RFR
NIS
K
NMQ
N
T
MG
QVTT
S
AEQ
M
LK
G
HKE
V
LI
FG
GQEVETKRFDK
VSN
R
MRLQ-----------G
M
K
MV
S
A
S
S
-
IS
DP
I
I
Q
L
IA
SLAL
--
AF
V
L
Y
A
A
S
FPS
V
M
D
SLT
A
G
T
I
T
V
V
F
S
SMI
A
L
MR
PL
KS
LT
NV
-------
N
A
QF
QR
GM
AA
CQTL
F
T
I
L
D
S
E
Q
EK
------
DEGK
R
VIE
R
A
T
G
DVE
FR
NV
T
FTYP
GR
D
V
PAL
R
NINL
K
IP
A
G
KT
VALVG
R
S
GSGKST
I
ASLI
T
R
F
YD
I
D
EGEI
L
M
DG
H
D
L
RE
Y
T
L
A
SLR
NQ
VA
L
VSQ
N
V
H
LF
N
DTVANNIA
YAR
TEQY
S
R
E
Q
IE
E
AAR
M
A
YAM
D
F
I
NK
M
DN
G
L
DT
V
I
GE
N
GV
L
LSGGQ
R
QRIAIARALL
RDSP
ILILDEATSA
L
D
TE
S
E
R
AIQ
A
AL
DELQ
K
N
RT
S
LVIAHRLSTI
E
K
ADEIVV
V
ED
G
V
IVERGTH
ND
LL
EHR
G
V
Y
A
Q
LH
K
M
Q
FG
fig|685038.3.peg.846
Escherichia coli O83:H1 str. NRG 857C (11-581/582)
Q
TFRRL
------
W
PTIAPFKA
G
L
IVA
GVAL
-
IL
NA
A
SDTF
ML
S
L
LK
P
----LLD
DG
FGK---
T
DRS
VL
M
W
M
P
LV
V
I
GL
MI
----
L
RG
--
ITS
Y
ISS
Y
CI
S
W
V
SG-
-
--K
VV
MT
M
R
R
R
LFGHMM
GM
P
V
SFFD
K
Q
S
TG
T
L
L
SR
I
T
Y
D
S
E
-------
Q
V
A
SSSSGALI
TVVR
EG
A
SI
I
G
---
L
F
I
MMF
YY
SWQL
-
SI
I
L
I
V
L
A
P
I
VS
I
AI
------
R
VVSK
RFR
NIS
K
NMQ
N
T
MG
QVTT
S
AEQ
M
LK
G
HKE
V
LI
FG
GQEVETKRFDK
VSN
R
MRLQ-----------G
M
K
MV
S
A
S
S
-
IS
DP
I
I
Q
L
IA
SLAL
--
AF
V
L
Y
A
A
S
FPS
V
M
D
SLT
A
G
T
I
T
V
V
F
S
SMI
A
L
MR
PL
KS
LT
NV
-------
N
A
QF
QR
GM
AA
CQTL
F
T
I
L
D
S
E
Q
EK
------
DEGK
R
VIE
R
A
T
G
DVE
FR
NV
T
FTYP
GR
D
V
PAL
R
NINL
K
IP
A
G
KT
VALVG
R
S
GSGKST
I
ASLI
T
R
F
YD
I
D
EGEI
L
M
DG
H
D
L
RE
Y
T
L
A
SLR
NQ
VA
L
VSQ
N
V
H
LF
N
DTVANNIA
YAR
TEQY
S
R
E
Q
IE
E
AAR
M
A
YAM
D
F
I
NK
M
DN
G
L
DT
V
I
GE
N
GV
L
LSGGQ
R
QRIAIARALL
RDSP
ILILDEATSA
L
D
TE
S
E
R
AIQ
A
AL
DELQ
K
N
RT
S
LVIAHRLSTI
E
K
ADEIVV
V
ED
G
V
IVERGTH
ND
LL
EHR
G
V
Y
A
Q
LH
K
M
Q
FG
fig|585035.6.peg.943
Escherichia coli S88 (11-581/582)
Q
TFRRL
------
W
PTIAPFKA
G
L
IVA
GVAL
-
IL
NA
A
SDTF
ML
S
L
LK
P
----LLD
DG
FGK---
T
DRS
VL
M
W
M
P
LV
V
I
GL
MI
----
L
RG
--
ITS
Y
ISS
Y
CI
S
W
V
SG-
-
--K
VV
MT
M
R
R
R
LFGHMM
GM
P
V
SFFD
K
Q
S
TG
T
L
L
SR
I
T
Y
D
S
E
-------
Q
V
A
SSSSGALI
TVVR
EG
A
SI
I
G
---
L
F
I
MMF
YY
SWQL
-
SI
I
L
I
V
L
A
P
I
VS
I
AI
------
R
VVSK
RFR
NIS
K
NMQ
N
T
MG
QVTT
S
AEQ
M
LK
G
HKE
V
LI
FG
GQEVETKRFDK
VSN
R
MRLQ-----------G
M
K
MV
S
A
S
S
-
IS
DP
I
I
Q
L
IA
SLAL
--
AF
V
L
Y
A
A
S
FPS
V
M
D
SLT
A
G
T
I
T
V
V
F
S
SMI
A
L
MR
PL
KS
LT
NV
-------
N
A
QF
QR
GM
AA
CQTL
F
T
I
L
D
S
E
Q
EK
------
DEGK
R
VIE
R
A
T
G
DVE
FR
NV
T
FTYP
GR
D
V
PAL
R
NINL
K
IP
A
G
KT
VALVG
R
S
GSGKST
I
ASLI
T
R
F
YD
I
D
EGEI
L
M
DG
H
D
L
RE
Y
T
L
A
SLR
NQ
VA
L
VSQ
N
V
H
LF
N
DTVANNIA
YAR
TEQY
S
R
E
Q
IE
E
AAR
M
A
YAM
D
F
I
NK
M
DN
G
L
DT
V
I
GE
N
GV
L
LSGGQ
R
QRIAIARALL
RDSP
ILILDEATSA
L
D
TE
S
E
R
AIQ
A
AL
DELQ
K
N
RT
S
LVIAHRLSTI
E
K
ADEIVV
V
ED
G
V
IVERGTH
ND
LL
EHR
G
V
Y
A
Q
LH
K
M
Q
FG
fig|431946.3.peg.875
Escherichia coli SE15 (11-581/582)
Q
TFRRL
------
W
PTIAPFKA
G
L
IVA
GVAL
-
IL
NA
A
SDTF
ML
S
L
LK
P
----LLD
DG
FGK---
T
DRS
VL
M
W
M
P
LV
V
I
GL
MI
----
L
RG
--
ITS
Y
ISS
Y
CI
S
W
V
SG-
-
--K
VV
MT
M
R
R
R
LFGHMM
GM
P
V
SFFD
K
Q
S
TG
T
L
L
SR
I
T
Y
D
S
E
-------
Q
V
A
SSSSGALI
TVVR
EG
A
SI
I
G
---
L
F
I
MMF
YY
SWQL
-
SI
I
L
I
V
L
A
P
I
VS
I
AI
------
R
VVSK
RFR
NIS
K
NMQ
N
T
MG
QVTT
S
AEQ
M
LK
G
HKE
V
LI
FG
GQEVETKRFDK
VSN
R
MRLQ-----------G
M
K
MV
S
A
S
S
-
IS
DP
I
I
Q
L
IA
SLAL
--
AF
V
L
Y
A
A
S
FPS
V
M
D
SLT
A
G
T
I
T
V
V
F
S
SMI
A
L
MR
PL
KS
LT
NV
-------
N
A
QF
QR
GM
AA
CQTL
F
T
I
L
D
S
E
Q
EK
------
DEGK
R
VIE
R
A
T
G
DVE
FR
NV
T
FTYP
GR
D
V
PAL
R
NINL
K
IP
A
G
KT
VALVG
R
S
GSGKST
I
ASLI
T
R
F
YD
I
D
EGEI
L
M
DG
H
D
L
RE
Y
T
L
A
SLR
NQ
VA
L
VSQ
N
V
H
LF
N
DTVANNIA
YAR
TEQY
S
R
E
Q
IE
E
AAR
M
A
YAM
D
F
I
NK
M
DN
G
L
DT
V
I
GE
N
GV
L
LSGGQ
R
QRIAIARALL
RDSP
ILILDEATSA
L
D
TE
S
E
R
AIQ
A
AL
DELQ
K
N
RT
S
LVIAHRLSTI
E
K
ADEIVV
V
ED
G
V
IVERGTH
ND
LL
EHR
G
V
Y
A
Q
LH
K
M
Q
FG
fig|656440.3.peg.830
Escherichia coli TA206 (11-581/582)
Q
TFRRL
------
W
PTIAPFKA
G
L
IVA
GVAL
-
IL
NA
A
SDTF
ML
S
L
LK
P
----LLD
DG
FGK---
T
DRS
VL
M
W
M
P
LV
V
I
GL
MI
----
L
RG
--
ITS
Y
ISS
Y
CI
S
W
V
SG-
-
--K
VV
MT
M
R
R
R
LFGHMM
GM
P
V
SFFD
K
Q
S
TG
T
L
L
SR
I
T
Y
D
S
E
-------
Q
V
A
SSSSGALI
TVVR
EG
A
SI
I
G
---
L
F
I
MMF
YY
SWQL
-
SI
I
L
I
V
L
A
P
I
VS
I
AI
------
R
VVSK
RFR
NIS
K
NMQ
N
T
MG
QVTT
S
AEQ
M
LK
G
HKE
V
LI
FG
GQEVETKRFDK
VSN
R
MRLQ-----------G
M
K
MV
S
A
S
S
-
IS
DP
I
I
Q
L
IA
SLAL
--
AF
V
L
Y
A
A
S
FPS
V
M
D
SLT
A
G
T
I
T
V
V
F
S
SMI
A
L
MR
PL
KS
LT
NV
-------
N
A
QF
QR
GM
AA
CQTL
F
T
I
L
D
S
E
Q
EK
------
DEGK
R
VIE
R
A
T
G
DVE
FR
NV
T
FTYP
GR
D
V
PAL
R
NINL
K
IP
A
G
KT
VALVG
R
S
GSGKST
I
ASLI
T
R
F
YD
I
D
EGEI
L
M
DG
H
D
L
RE
Y
T
L
A
SLR
NQ
VA
L
VSQ
N
V
H
LF
N
DTVANNIA
YAR
TEQY
S
R
E
Q
IE
E
AAR
M
A
YAM
D
F
I
NK
M
DN
G
L
DT
V
I
GE
N
GV
L
LSGGQ
R
QRIAIARALL
RDSP
ILILDEATSA
L
D
TE
S
E
R
AIQ
A
AL
DELQ
K
N
RT
S
LVIAHRLSTI
E
K
ADEIVV
V
ED
G
V
IVERGTH
ND
LL
EHR
G
V
Y
A
Q
LH
K
M
Q
FG
fig|364106.7.peg.1064
Escherichia coli UTI89 (11-581/582)
Q
TFRRL
------
W
PTIAPFKA
G
L
IVA
GVAL
-
IL
NA
A
SDTF
ML
S
L
LK
P
----LLD
DG
FGK---
T
DRS
VL
M
W
M
P
LV
V
I
GL
MI
----
L
RG
--
ITS
Y
ISS
Y
CI
S
W
V
SG-
-
--K
VV
MT
M
R
R
R
LFGHMM
GM
P
V
SFFD
K
Q
S
TG
T
L
L
SR
I
T
Y
D
S
E
-------
Q
V
A
SSSSGALI
TVVR
EG
A
SI
I
G
---
L
F
I
MMF
YY
SWQL
-
SI
I
L
I
V
L
A
P
I
VS
I
AI
------
R
VVSK
RFR
NIS
K
NMQ
N
T
MG
QVTT
S
AEQ
M
LK
G
HKE
V
LI
FG
GQEVETKRFDK
VSN
R
MRLQ-----------G
M
K
MV
S
A
S
S
-
IS
DP
I
I
Q
L
IA
SLAL
--
AF
V
L
Y
A
A
S
FPS
V
M
D
SLT
A
G
T
I
T
V
V
F
S
SMI
A
L
MR
PL
KS
LT
NV
-------
N
A
QF
QR
GM
AA
CQTL
F
T
I
L
D
S
E
Q
EK
------
DEGK
R
VIE
R
A
T
G
DVE
FR
NV
T
FTYP
GR
D
V
PAL
R
NINL
K
IP
A
G
KT
VALVG
R
S
GSGKST
I
ASLI
T
R
F
YD
I
D
EGEI
L
M
DG
H
D
L
RE
Y
T
L
A
SLR
NQ
VA
L
VSQ
N
V
H
LF
N
DTVANNIA
YAR
TEQY
S
R
E
Q
IE
E
AAR
M
A
YAM
D
F
I
NK
M
DN
G
L
DT
V
I
GE
N
GV
L
LSGGQ
R
QRIAIARALL
RDSP
ILILDEATSA
L
D
TE
S
E
R
AIQ
A
AL
DELQ
K
N
RT
S
LVIAHRLSTI
E
K
ADEIVV
V
ED
G
V
IVERGTH
ND
LL
EHR
G
V
Y
A
Q
LH
K
M
Q
FG
fig|364106.8.peg.1061
Escherichia coli UTI89 (11-581/582)
Q
TFRRL
------
W
PTIAPFKA
G
L
IVA
GVAL
-
IL
NA
A
SDTF
ML
S
L
LK
P
----LLD
DG
FGK---
T
DRS
VL
M
W
M
P
LV
V
I
GL
MI
----
L
RG
--
ITS
Y
ISS
Y
CI
S
W
V
SG-
-
--K
VV
MT
M
R
R
R
LFGHMM
GM
P
V
SFFD
K
Q
S
TG
T
L
L
SR
I
T
Y
D
S
E
-------
Q
V
A
SSSSGALI
TVVR
EG
A
SI
I
G
---
L
F
I
MMF
YY
SWQL
-
SI
I
L
I
V
L
A
P
I
VS
I
AI
------
R
VVSK
RFR
NIS
K
NMQ
N
T
MG
QVTT
S
AEQ
M
LK
G
HKE
V
LI
FG
GQEVETKRFDK
VSN
R
MRLQ-----------G
M
K
MV
S
A
S
S
-
IS
DP
I
I
Q
L
IA
SLAL
--
AF
V
L
Y
A
A
S
FPS
V
M
D
SLT
A
G
T
I
T
V
V
F
S
SMI
A
L
MR
PL
KS
LT
NV
-------
N
A
QF
QR
GM
AA
CQTL
F
T
I
L
D
S
E
Q
EK
------
DEGK
R
VIE
R
A
T
G
DVE
FR
NV
T
FTYP
GR
D
V
PAL
R
NINL
K
IP
A
G
KT
VALVG
R
S
GSGKST
I
ASLI
T
R
F
YD
I
D
EGEI
L
M
DG
H
D
L
RE
Y
T
L
A
SLR
NQ
VA
L
VSQ
N
V
H
LF
N
DTVANNIA
YAR
TEQY
S
R
E
Q
IE
E
AAR
M
A
YAM
D
F
I
NK
M
DN
G
L
DT
V
I
GE
N
GV
L
LSGGQ
R
QRIAIARALL
RDSP
ILILDEATSA
L
D
TE
S
E
R
AIQ
A
AL
DELQ
K
N
RT
S
LVIAHRLSTI
E
K
ADEIVV
V
ED
G
V
IVERGTH
ND
LL
EHR
G
V
Y
A
Q
LH
K
M
Q
FG
fig|562.376.peg.4686
Escherichia coli WV_060327 (11-581/582)
Q
TFRRL
------
W
PTIAPFKA
G
L
IVA
GVAL
-
IL
NA
A
SDTF
ML
S
L
LK
P
----LLD
DG
FGK---
T
DRS
VL
M
W
M
P
LV
V
I
GL
MI
----
L
RG
--
ITS
Y
ISS
Y
CI
S
W
V
SG-
-
--K
VV
MT
M
R
R
R
LFGHMM
GM
P
V
SFFD
K
Q
S
TG
T
L
L
SR
I
T
Y
D
S
E
-------
Q
V
A
SSSSGALI
TVVR
EG
A
SI
I
G
---
L
F
I
MMF
YY
SWQL
-
SI
I
L
I
V
L
A
P
I
VS
I
AI
------
R
VVSK
RFR
NIS
K
NMQ
N
T
MG
QVTT
S
AEQ
M
LK
G
HKE
V
LI
FG
GQEVETKRFDK
VSN
R
MRLQ-----------G
M
K
MV
S
A
S
S
-
IS
DP
I
I
Q
L
IA
SLAL
--
AF
V
L
Y
A
A
S
FPS
V
M
D
SLT
A
G
T
I
T
V
V
F
S
SMI
A
L
MR
PL
KS
LT
NV
-------
N
A
QF
QR
GM
AA
CQTL
F
T
I
L
D
S
E
Q
EK
------
DEGK
R
VIE
R
A
T
G
DVE
FR
NV
T
FTYP
GR
D
V
PAL
R
NINL
K
IP
A
G
KT
VALVG
R
S
GSGKST
I
ASLI
T
R
F
YD
I
D
EGEI
L
M
DG
H
D
L
RE
Y
T
L
A
SLR
NQ
VA
L
VSQ
N
V
H
LF
N
DTVANNIA
YAR
TEQY
S
R
E
Q
IE
E
AAR
M
A
YAM
D
F
I
NK
M
DN
G
L
DT
V
I
GE
N
GV
L
LSGGQ
R
QRIAIARALL
RDSP
ILILDEATSA
L
D
TE
S
E
R
AIQ
A
AL
DELQ
K
N
RT
S
LVIAHRLSTI
E
K
ADEIVV
V
ED
G
V
IVERGTH
ND
LL
EHR
G
V
Y
A
Q
LH
K
M
Q
FG
fig|749527.3.peg.2405
Escherichia coli MS 21-1 (11-581/582)
Q
TFRRL
------
W
PTIAPFKA
G
L
IVA
GVAL
-
IL
NA
A
SDTF
ML
S
L
LK
P
----LLD
DG
FGK---
T
DRS
VL
V
W
M
P
LV
V
I
GL
MI
----
L
RG
--
ITS
Y
VSS
Y
CI
S
W
V
SG-
-
--K
VV
MT
M
R
R
R
LFGHMM
GM
P
V
SFFD
K
Q
S
TG
T
L
L
SR
I
T
Y
D
S
E
-------
Q
V
A
SSSSGALI
TVVR
EG
A
SI
I
G
---
L
F
I
MMF
YY
SWQL
-
SI
I
L
I
V
L
A
P
I
VS
I
AI
------
R
VVSK
RFR
NIS
K
NMQ
N
T
MG
QVTT
S
AEQ
M
LK
G
HKE
V
LI
FG
GQEVETKRFDK
VSN
R
MRLQ-----------G
M
K
MV
S
A
S
S
-
IS
DP
I
I
Q
L
IA
SLAL
--
AF
V
L
Y
V
A
S
FPS
V
M
D
SLT
A
G
T
I
T
V
V
F
S
SMI
A
L
MR
PL
KS
LT
NV
-------
N
A
QF
QR
GM
AA
CQTL
F
T
I
L
D
S
E
Q
EK
------
DEGK
R
VIE
R
A
T
G
DVE
FR
NV
T
FTYP
GR
D
V
PAL
R
NINL
K
IP
A
G
KT
VALVG
R
S
GSGKST
I
ASLI
T
R
F
YD
I
D
EGEI
L
M
DG
H
D
L
RE
Y
T
L
A
SLR
NQ
VA
L
VSQ
N
V
H
LF
N
DTVANNIA
YAR
TEQY
S
R
E
Q
IE
E
AAR
M
A
YAM
D
F
I
NK
M
DN
G
L
DT
V
I
GE
N
GV
L
LSGGQ
R
QRIAIARALL
RDSP
ILILDEATSA
L
D
TE
S
E
R
AIQ
A
AL
DELQ
K
N
RT
S
LVIAHRLSTI
E
K
ADEIVV
V
ED
G
V
IVERGTH
ND
LL
EHR
G
V
Y
A
Q
LH
K
M
Q
FG
fig|749532.3.peg.1499
Escherichia coli MS 78-1 (11-581/582)
Q
TFRRL
------
W
PTIAPFKA
G
L
IVA
GVAL
-
IL
NA
A
SDTF
ML
S
L
LK
P
----LLD
DG
FGK---
T
DRS
VL
V
W
M
P
LV
V
I
GL
MI
----
L
RG
--
ITS
Y
VSS
Y
CI
S
W
V
SG-
-
--K
VV
MT
M
R
R
R
LFGHMM
GM
P
V
SFFD
K
Q
S
TG
T
L
L
SR
I
T
Y
D
S
E
-------
Q
V
A
SSSSGALI
TVVR
EG
A
SI
I
G
---
L
F
I
MMF
YY
SWQL
-
SI
I
L
I
V
L
A
P
I
VS
I
AI
------
R
VVSK
RFR
NIS
K
NMQ
N
T
MG
QVTT
S
AEQ
M
LK
G
HKE
V
LI
FG
GQEVETKRFDK
VSN
R
MRLQ-----------G
M
K
MV
S
A
S
S
-
IS
DP
I
I
Q
L
IA
SLAL
--
AF
V
L
Y
A
A
S
FPS
V
M
D
SLT
A
G
T
I
T
V
V
F
S
SMI
A
L
MR
PL
KS
LT
NV
-------
N
A
QF
QR
GM
AA
CQTL
F
S
I
L
D
S
E
Q
EK
------
DEGK
R
VIE
R
A
T
G
DVE
FR
NV
T
FTYP
GR
D
V
PAL
R
NINL
K
IP
A
G
KT
VALVG
R
S
GSGKST
I
ASLI
T
R
F
YD
I
D
EGEI
L
M
DG
H
D
L
RE
Y
T
L
A
SLR
NQ
VA
L
VSQ
N
V
H
LF
N
DTVANNIA
YAR
TEQY
S
R
E
Q
IE
E
AAR
M
A
YAM
D
F
I
NK
M
DN
G
L
DT
V
I
GE
N
GV
L
LSGGQ
R
QRIAIARALL
RDSP
ILILDEATSA
L
D
TE
S
E
R
AIQ
A
AL
DELQ
K
N
RT
S
LVIAHRLSTI
E
K
ADEIVV
V
ED
G
V
IVERGTH
ND
LL
EHR
G
V
Y
A
Q
LH
K
M
Q
FG
fig|6666666.5357.peg.2564
Escherichia coli TY-2482 (11-581/582)
Q
TFRRL
------
W
PTIAPFK
T
G
L
IVA
GVAL
-
IL
NA
A
SDTF
ML
S
L
LK
P
----LLD
DG
FGK---
T
DRS
VL
V
W
M
P
LV
V
I
GL
MI
----
L
RG
--
ITS
Y
VSS
Y
CI
S
W
V
SG-
-
--K
VV
MT
M
R
R
R
LFGHMM
GM
P
V
SFFD
K
Q
S
TG
T
L
L
SR
I
T
Y
D
S
E
-------
Q
V
A
SSSSGALI
TVVR
EG
A
SI
I
G
---
L
F
I
MMF
YY
SWQL
-
SI
I
L
I
V
L
A
P
I
VS
I
AI
------
R
VVSK
RFR
NIS
K
NMQ
N
T
MG
QVTT
S
AEQ
M
LK
G
HKE
V
LI
FG
GQEVETKRFDK
VSN
R
MRLQ-----------G
M
K
MV
S
A
S
S
-
IS
DP
I
I
Q
L
IA
SLAL
--
AF
V
L
Y
A
A
S
FPS
V
M
D
SLT
A
G
T
I
T
V
V
F
S
SMI
A
L
MR
PL
KS
LT
NV
-------
N
A
QF
QR
GM
AA
CQTL
F
T
I
L
D
S
E
Q
EK
------
DEGK
R
VIE
R
A
T
G
DVE
FR
NV
T
FTYP
GR
D
V
PAL
R
NINL
K
IP
A
G
KT
VALVG
R
S
GSGKST
I
ASLI
T
R
F
YD
I
D
EGEI
L
M
DG
H
D
L
RE
Y
T
L
A
SLR
NQ
VA
L
VSQ
N
V
H
LF
N
DTVANNIA
YAR
TEQY
S
R
E
Q
IE
E
AAR
M
A
YAM
D
F
I
NK
M
DN
G
L
DT
V
I
GE
N
GV
L
LSGGQ
R
QRIAIARALL
RDSP
ILILDEATSA
L
D
TE
S
E
R
AIQ
A
AL
DELQ
K
N
RT
S
LVIAHRLSTI
E
K
ADEIVV
V
ED
G
V
IVERGTH
ND
LL
EHR
G
V
Y
A
Q
LH
K
M
Q
FG
fig|1040638.4.peg.4765
Escherichia coli O104:H4 str. LB226692 (11-581/582)
Q
TFRRL
------
W
PTIAPFKA
G
L
IVA
GVAL
-
IL
NA
A
SDTF
ML
S
L
LK
P
----LLD
DG
FGK---
T
DRS
VL
V
W
M
P
LV
V
I
GL
MI
----
L
RG
--
ITS
Y
VSS
Y
CI
S
W
V
SG-
-
--K
VV
MT
M
R
R
R
LFGHMM
GM
P
V
SFFD
K
Q
S
TG
T
L
L
SR
I
T
Y
D
S
E
-------
Q
V
A
SSSSGALI
TVVR
EG
A
SI
I
G
---
L
F
I
MMF
YY
SWQL
-
SI
I
L
I
V
L
A
P
I
VS
I
AI
------
R
VVSK
RFR
NIS
K
NMQ
N
T
MG
QVTT
S
AEQ
M
LK
G
HKE
V
LI
FG
GQEVETKRFDK
VSN
R
MRLQ-----------G
M
K
MV
S
A
S
S
-
IS
DP
I
I
Q
L
IA
SLAL
--
AF
V
L
Y
A
A
S
FPS
V
M
D
SLT
A
G
T
I
T
V
V
F
S
SMI
A
L
MR
PL
KS
LT
NV
-------
N
A
QF
QR
GM
AA
CQTL
F
T
I
L
D
S
E
Q
EK
------
DEGK
R
VIE
R
A
T
G
DVE
FR
NV
T
FTYP
GR
D
V
PAL
R
NINL
K
IP
A
G
KT
VALVG
R
S
GSGKST
I
ASLI
T
R
F
YD
I
D
EGEI
L
M
DG
H
D
L
RE
Y
T
L
A
SLR
NQ
VA
L
VSQ
N
V
H
LF
N
DTVANNIA
YAR
TEQY
S
R
E
Q
IE
E
AAR
M
A
YAM
D
F
I
NK
M
DN
G
L
DT
V
I
GE
N
GV
L
LSGGQ
R
QRIAIARALL
RDSP
ILILDEATSA
L
D
TE
S
E
R
AIQ
A
AL
DELQ
K
N
RT
S
LVIAHRLSTI
E
K
ADEIVV
V
ED
G
V
IVERGTH
ND
LL
EHR
G
V
Y
A
Q
LH
K
M
Q
FG
fig|562.371.peg.2119
Escherichia coli 1044A (11-581/582)
Q
TFRRL
------
W
PTIAPFKA
G
L
IVA
GVAL
-
IL
NA
A
SDTF
ML
S
L
LK
P
----LLD
DG
FGK---
T
DRS
VL
V
W
M
P
LV
V
I
GL
MI
----
L
RG
--
ITS
Y
VSS
Y
CI
S
W
V
SG-
-
--K
VV
MT
M
R
R
R
LFGHMM
GM
P
V
SFFD
K
Q
S
TG
T
L
L
SR
I
T
Y
D
S
E
-------
Q
V
A
SSSSGALI
TVVR
EG
A
SI
I
G
---
L
F
I
MMF
YY
SWQL
-
SI
I
L
I
V
L
A
P
I
VS
I
AI
------
R
VVSK
RFR
NIS
K
NMQ
N
T
MG
QVTT
S
AEQ
M
LK
G
HKE
V
LI
FG
GQEVETKRFDK
VSN
R
MRLQ-----------G
M
K
MV
S
A
S
S
-
IS
DP
I
I
Q
L
IA
SLAL
--
AF
V
L
Y
A
A
S
FPS
V
M
D
SLT
A
G
T
I
T
V
V
F
S
SMI
A
L
MR
PL
KS
LT
NV
-------
N
A
QF
QR
GM
AA
CQTL
F
T
I
L
D
S
E
Q
EK
------
DEGK
R
VIE
R
A
T
G
DVE
FR
NV
T
FTYP
GR
D
V
PAL
R
NINL
K
IP
A
G
KT
VALVG
R
S
GSGKST
I
ASLI
T
R
F
YD
I
D
EGEI
L
M
DG
H
D
L
RE
Y
T
L
A
SLR
NQ
VA
L
VSQ
N
V
H
LF
N
DTVANNIA
YAR
TEQY
S
R
E
Q
IE
E
AAR
M
A
YAM
D
F
I
NK
M
DN
G
L
DT
V
I
GE
N
GV
L
LSGGQ
R
QRIAIARALL
RDSP
ILILDEATSA
L
D
TE
S
E
R
AIQ
A
AL
DELQ
K
N
RT
S
LVIAHRLSTI
E
K
ADEIVV
V
ED
G
V
IVERGTH
ND
LL
EHR
G
V
Y
A
Q
LH
K
M
Q
FG
fig|562.373.peg.1101
Escherichia coli 1125A (11-581/582)
Q
TFRRL
------
W
PTIAPFKA
G
L
IVA
GVAL
-
IL
NA
A
SDTF
ML
S
L
LK
P
----LLD
DG
FGK---
T
DRS
VL
V
W
M
P
LV
V
I
GL
MI
----
L
RG
--
ITS
Y
VSS
Y
CI
S
W
V
SG-
-
--K
VV
MT
M
R
R
R
LFGHMM
GM
P
V
SFFD
K
Q
S
TG
T
L
L
SR
I
T
Y
D
S
E
-------
Q
V
A
SSSSGALI
TVVR
EG
A
SI
I
G
---
L
F
I
MMF
YY
SWQL
-
SI
I
L
I
V
L
A
P
I
VS
I
AI
------
R
VVSK
RFR
NIS
K
NMQ
N
T
MG
QVTT
S
AEQ
M
LK
G
HKE
V
LI
FG
GQEVETKRFDK
VSN
R
MRLQ-----------G
M
K
MV
S
A
S
S
-
IS
DP
I
I
Q
L
IA
SLAL
--
AF
V
L
Y
A
A
S
FPS
V
M
D
SLT
A
G
T
I
T
V
V
F
S
SMI
A
L
MR
PL
KS
LT
NV
-------
N
A
QF
QR
GM
AA
CQTL
F
T
I
L
D
S
E
Q
EK
------
DEGK
R
VIE
R
A
T
G
DVE
FR
NV
T
FTYP
GR
D
V
PAL
R
NINL
K
IP
A
G
KT
VALVG
R
S
GSGKST
I
ASLI
T
R
F
YD
I
D
EGEI
L
M
DG
H
D
L
RE
Y
T
L
A
SLR
NQ
VA
L
VSQ
N
V
H
LF
N
DTVANNIA
YAR
TEQY
S
R
E
Q
IE
E
AAR
M
A
YAM
D
F
I
NK
M
DN
G
L
DT
V
I
GE
N
GV
L
LSGGQ
R
QRIAIARALL
RDSP
ILILDEATSA
L
D
TE
S
E
R
AIQ
A
AL
DELQ
K
N
RT
S
LVIAHRLSTI
E
K
ADEIVV
V
ED
G
V
IVERGTH
ND
LL
EHR
G
V
Y
A
Q
LH
K
M
Q
FG
fig|562.372.peg.967
Escherichia coli 1212A (11-581/582)
Q
TFRRL
------
W
PTIAPFKA
G
L
IVA
GVAL
-
IL
NA
A
SDTF
ML
S
L
LK
P
----LLD
DG
FGK---
T
DRS
VL
V
W
M
P
LV
V
I
GL
MI
----
L
RG
--
ITS
Y
VSS
Y
CI
S
W
V
SG-
-
--K
VV
MT
M
R
R
R
LFGHMM
GM
P
V
SFFD
K
Q
S
TG
T
L
L
SR
I
T
Y
D
S
E
-------
Q
V
A
SSSSGALI
TVVR
EG
A
SI
I
G
---
L
F
I
MMF
YY
SWQL
-
SI
I
L
I
V
L
A
P
I
VS
I
AI
------
R
VVSK
RFR
NIS
K
NMQ
N
T
MG
QVTT
S
AEQ
M
LK
G
HKE
V
LI
FG
GQEVETKRFDK
VSN
R
MRLQ-----------G
M
K
MV
S
A
S
S
-
IS
DP
I
I
Q
L
IA
SLAL
--
AF
V
L
Y
A
A
S
FPS
V
M
D
SLT
A
G
T
I
T
V
V
F
S
SMI
A
L
MR
PL
KS
LT
NV
-------
N
A
QF
QR
GM
AA
CQTL
F
T
I
L
D
S
E
Q
EK
------
DEGK
R
VIE
R
A
T
G
DVE
FR
NV
T
FTYP
GR
D
V
PAL
R
NINL
K
IP
A
G
KT
VALVG
R
S
GSGKST
I
ASLI
T
R
F
YD
I
D
EGEI
L
M
DG
H
D
L
RE
Y
T
L
A
SLR
NQ
VA
L
VSQ
N
V
H
LF
N
DTVANNIA
YAR
TEQY
S
R
E
Q
IE
E
AAR
M
A
YAM
D
F
I
NK
M
DN
G
L
DT
V
I
GE
N
GV
L
LSGGQ
R
QRIAIARALL
RDSP
ILILDEATSA
L
D
TE
S
E
R
AIQ
A
AL
DELQ
K
N
RT
S
LVIAHRLSTI
E
K
ADEIVV
V
ED
G
V
IVERGTH
ND
LL
EHR
G
V
Y
A
Q
LH
K
M
Q
FG
fig|670888.3.peg.1530
Escherichia coli 1827-70 (11-581/582)
Q
TFRRL
------
W
PTIAPFKA
G
L
IVA
GVAL
-
IL
NA
A
SDTF
ML
S
L
LK
P
----LLD
DG
FGK---
T
DRS
VL
V
W
M
P
LV
V
I
GL
MI
----
L
RG
--
ITS
Y
VSS
Y
CI
S
W
V
SG-
-
--K
VV
MT
M
R
R
R
LFGHMM
GM
P
V
SFFD
K
Q
S
TG
T
L
L
SR
I
T
Y
D
S
E
-------
Q
V
A
SSSSGALI
TVVR
EG
A
SI
I
G
---
L
F
I
MMF
YY
SWQL
-
SI
I
L
I
V
L
A
P
I
VS
I
AI
------
R
VVSK
RFR
NIS
K
NMQ
N
T
MG
QVTT
S
AEQ
M
LK
G
HKE
V
LI
FG
GQEVETKRFDK
VSN
R
MRLQ-----------G
M
K
MV
S
A
S
S
-
IS
DP
I
I
Q
L
IA
SLAL
--
AF
V
L
Y
A
A
S
FPS
V
M
D
SLT
A
G
T
I
T
V
V
F
S
SMI
A
L
MR
PL
KS
LT
NV
-------
N
A
QF
QR
GM
AA
CQTL
F
T
I
L
D
S
E
Q
EK
------
DEGK
R
VIE
R
A
T
G
DVE
FR
NV
T
FTYP
GR
D
V
PAL
R
NINL
K
IP
A
G
KT
VALVG
R
S
GSGKST
I
ASLI
T
R
F
YD
I
D
EGEI
L
M
DG
H
D
L
RE
Y
T
L
A
SLR
NQ
VA
L
VSQ
N
V
H
LF
N
DTVANNIA
YAR
TEQY
S
R
E
Q
IE
E
AAR
M
A
YAM
D
F
I
NK
M
DN
G
L
DT
V
I
GE
N
GV
L
LSGGQ
R
QRIAIARALL
RDSP
ILILDEATSA
L
D
TE
S
E
R
AIQ
A
AL
DELQ
K
N
RT
S
LVIAHRLSTI
E
K
ADEIVV
V
ED
G
V
IVERGTH
ND
LL
EHR
G
V
Y
A
Q
LH
K
M
Q
FG
fig|344610.3.peg.3966
Escherichia coli 53638 (11-581/582)
Q
TFRRL
------
W
PTIAPFKA
G
L
IVA
GVAL
-
IL
NA
A
SDTF
ML
S
L
LK
P
----LLD
DG
FGK---
T
DRS
VL
V
W
M
P
LV
V
I
GL
MI
----
L
RG
--
ITS
Y
VSS
Y
CI
S
W
V
SG-
-
--K
VV
MT
M
R
R
R
LFGHMM
GM
P
V
SFFD
K
Q
S
TG
T
L
L
SR
I
T
Y
D
S
E
-------
Q
V
A
SSSSGALI
TVVR
EG
A
SI
I
G
---
L
F
I
MMF
YY
SWQL
-
SI
I
L
I
V
L
A
P
I
VS
I
AI
------
R
VVSK
RFR
NIS
K
NMQ
N
T
MG
QVTT
S
AEQ
M
LK
G
HKE
V
LI
FG
GQEVETKRFDK
VSN
R
MRLQ-----------G
M
K
MV
S
A
S
S
-
IS
DP
I
I
Q
L
IA
SLAL
--
AF
V
L
Y
A
A
S
FPS
V
M
D
SLT
A
G
T
I
T
V
V
F
S
SMI
A
L
MR
PL
KS
LT
NV
-------
N
A
QF
QR
GM
AA
CQTL
F
T
I
L
D
S
E
Q
EK
------
DEGK
R
VIE
R
A
T
G
DVE
FR
NV
T
FTYP
GR
D
V
PAL
R
NINL
K
IP
A
G
KT
VALVG
R
S
GSGKST
I
ASLI
T
R
F
YD
I
D
EGEI
L
M
DG
H
D
L
RE
Y
T
L
A
SLR
NQ
VA
L
VSQ
N
V
H
LF
N
DTVANNIA
YAR
TEQY
S
R
E
Q
IE
E
AAR
M
A
YAM
D
F
I
NK
M
DN
G
L
DT
V
I
GE
N
GV
L
LSGGQ
R
QRIAIARALL
RDSP
ILILDEATSA
L
D
TE
S
E
R
AIQ
A
AL
DELQ
K
N
RT
S
LVIAHRLSTI
E
K
ADEIVV
V
ED
G
V
IVERGTH
ND
LL
EHR
G
V
Y
A
Q
LH
K
M
Q
FG
fig|344610.7.peg.745
Escherichia coli 53638 (11-581/582)
Q
TFRRL
------
W
PTIAPFKA
G
L
IVA
GVAL
-
IL
NA
A
SDTF
ML
S
L
LK
P
----LLD
DG
FGK---
T
DRS
VL
V
W
M
P
LV
V
I
GL
MI
----
L
RG
--
ITS
Y
VSS
Y
CI
S
W
V
SG-
-
--K
VV
MT
M
R
R
R
LFGHMM
GM
P
V
SFFD
K
Q
S
TG
T
L
L
SR
I
T
Y
D
S
E
-------
Q
V
A
SSSSGALI
TVVR
EG
A
SI
I
G
---
L
F
I
MMF
YY
SWQL
-
SI
I
L
I
V
L
A
P
I
VS
I
AI
------
R
VVSK
RFR
NIS
K
NMQ
N
T
MG
QVTT
S
AEQ
M
LK
G
HKE
V
LI
FG
GQEVETKRFDK
VSN
R
MRLQ-----------G
M
K
MV
S
A
S
S
-
IS
DP
I
I
Q
L
IA
SLAL
--
AF
V
L
Y
A
A
S
FPS
V
M
D
SLT
A
G
T
I
T
V
V
F
S
SMI
A
L
MR
PL
KS
LT
NV
-------
N
A
QF
QR
GM
AA
CQTL
F
T
I
L
D
S
E
Q
EK
------
DEGK
R
VIE
R
A
T
G
DVE
FR
NV
T
FTYP
GR
D
V
PAL
R
NINL
K
IP
A
G
KT
VALVG
R
S
GSGKST
I
ASLI
T
R
F
YD
I
D
EGEI
L
M
DG
H
D
L
RE
Y
T
L
A
SLR
NQ
VA
L
VSQ
N
V
H
LF
N
DTVANNIA
YAR
TEQY
S
R
E
Q
IE
E
AAR
M
A
YAM
D
F
I
NK
M
DN
G
L
DT
V
I
GE
N
GV
L
LSGGQ
R
QRIAIARALL
RDSP
ILILDEATSA
L
D
TE
S
E
R
AIQ
A
AL
DELQ
K
N
RT
S
LVIAHRLSTI
E
K
ADEIVV
V
ED
G
V
IVERGTH
ND
LL
EHR
G
V
Y
A
Q
LH
K
M
Q
FG
fig|562.374.peg.2501
Escherichia coli 536A (11-581/582)
Q
TFRRL
------
W
PTIAPFKA
G
L
IVA
GVAL
-
IL
NA
A
SDTF
ML
S
L
LK
P
----LLD
DG
FGK---
T
DRS
VL
V
W
M
P
LV
V
I
GL
MI
----
L
RG
--
ITS
Y
VSS
Y
CI
S
W
V
SG-
-
--K
VV
MT
M
R
R
R
LFGHMM
GM
P
V
SFFD
K
Q
S
TG
T
L
L
SR
I
T
Y
D
S
E
-------
Q
V
A
SSSSGALI
TVVR
EG
A
SI
I
G
---
L
F
I
MMF
YY
SWQL
-
SI
I
L
I
V
L
A
P
I
VS
I
AI
------
R
VVSK
RFR
NIS
K
NMQ
N
T
MG
QVTT
S
AEQ
M
LK
G
HKE
V
LI
FG
GQEVETKRFDK
VSN
R
MRLQ-----------G
M
K
MV
S
A
S
S
-
IS
DP
I
I
Q
L
IA
SLAL
--
AF
V
L
Y
A
A
S
FPS
V
M
D
SLT
A
G
T
I
T
V
V
F
S
SMI
A
L
MR
PL
KS
LT
NV
-------
N
A
QF
QR
GM
AA
CQTL
F
T
I
L
D
S
E
Q
EK
------
DEGK
R
VIE
R
A
T
G
DVE
FR
NV
T
FTYP
GR
D
V
PAL
R
NINL
K
IP
A
G
KT
VALVG
R
S
GSGKST
I
ASLI
T
R
F
YD
I
D
EGEI
L
M
DG
H
D
L
RE
Y
T
L
A
SLR
NQ
VA
L
VSQ
N
V
H
LF
N
DTVANNIA
YAR
TEQY
S
R
E
Q
IE
E
AAR
M
A
YAM
D
F
I
NK
M
DN
G
L
DT
V
I
GE
N
GV
L
LSGGQ
R
QRIAIARALL
RDSP
ILILDEATSA
L
D
TE
S
E
R
AIQ
A
AL
DELQ
K
N
RT
S
LVIAHRLSTI
E
K
ADEIVV
V
ED
G
V
IVERGTH
ND
LL
EHR
G
V
Y
A
Q
LH
K
M
Q
FG
fig|585055.6.peg.976
Escherichia coli 55989 (11-581/582)
Q
TFRRL
------
W
PTIAPFKA
G
L
IVA
GVAL
-
IL
NA
A
SDTF
ML
S
L
LK
P
----LLD
DG
FGK---
T
DRS
VL
V
W
M
P
LV
V
I
GL
MI
----
L
RG
--
ITS
Y
VSS
Y
CI
S
W
V
SG-
-
--K
VV
MT
M
R
R
R
LFGHMM
GM
P
V
SFFD
K
Q
S
TG
T
L
L
SR
I
T
Y
D
S
E
-------
Q
V
A
SSSSGALI
TVVR
EG
A
SI
I
G
---
L
F
I
MMF
YY
SWQL
-
SI
I
L
I
V
L
A
P
I
VS
I
AI
------
R
VVSK
RFR
NIS
K
NMQ
N
T
MG
QVTT
S
AEQ
M
LK
G
HKE
V
LI
FG
GQEVETKRFDK
VSN
R
MRLQ-----------G
M
K
MV
S
A
S
S
-
IS
DP
I
I
Q
L
IA
SLAL
--
AF
V
L
Y
A
A
S
FPS
V
M
D
SLT
A
G
T
I
T
V
V
F
S
SMI
A
L
MR
PL
KS
LT
NV
-------
N
A
QF
QR
GM
AA
CQTL
F
T
I
L
D
S
E
Q
EK
------
DEGK
R
VIE
R
A
T
G
DVE
FR
NV
T
FTYP
GR
D
V
PAL
R
NINL
K
IP
A
G
KT
VALVG
R
S
GSGKST
I
ASLI
T
R
F
YD
I
D
EGEI
L
M
DG
H
D
L
RE
Y
T
L
A
SLR
NQ
VA
L
VSQ
N
V
H
LF
N
DTVANNIA
YAR
TEQY
S
R
E
Q
IE
E
AAR
M
A
YAM
D
F
I
NK
M
DN
G
L
DT
V
I
GE
N
GV
L
LSGGQ
R
QRIAIARALL
RDSP
ILILDEATSA
L
D
TE
S
E
R
AIQ
A
AL
DELQ
K
N
RT
S
LVIAHRLSTI
E
K
ADEIVV
V
ED
G
V
IVERGTH
ND
LL
EHR
G
V
Y
A
Q
LH
K
M
Q
FG
fig|585055.8.peg.978
Escherichia coli 55989 (11-581/582)
Q
TFRRL
------
W
PTIAPFKA
G
L
IVA
GVAL
-
IL
NA
A
SDTF
ML
S
L
LK
P
----LLD
DG
FGK---
T
DRS
VL
V
W
M
P
LV
V
I
GL
MI
----
L
RG
--
ITS
Y
VSS
Y
CI
S
W
V
SG-
-
--K
VV
MT
M
R
R
R
LFGHMM
GM
P
V
SFFD
K
Q
S
TG
T
L
L
SR
I
T
Y
D
S
E
-------
Q
V
A
SSSSGALI
TVVR
EG
A
SI
I
G
---
L
F
I
MMF
YY
SWQL
-
SI
I
L
I
V
L
A
P
I
VS
I
AI
------
R
VVSK
RFR
NIS
K
NMQ
N
T
MG
QVTT
S
AEQ
M
LK
G
HKE
V
LI
FG
GQEVETKRFDK
VSN
R
MRLQ-----------G
M
K
MV
S
A
S
S
-
IS
DP
I
I
Q
L
IA
SLAL
--
AF
V
L
Y
A
A
S
FPS
V
M
D
SLT
A
G
T
I
T
V
V
F
S
SMI
A
L
MR
PL
KS
LT
NV
-------
N
A
QF
QR
GM
AA
CQTL
F
T
I
L
D
S
E
Q
EK
------
DEGK
R
VIE
R
A
T
G
DVE
FR
NV
T
FTYP
GR
D
V
PAL
R
NINL
K
IP
A
G
KT
VALVG
R
S
GSGKST
I
ASLI
T
R
F
YD
I
D
EGEI
L
M
DG
H
D
L
RE
Y
T
L
A
SLR
NQ
VA
L
VSQ
N
V
H
LF
N
DTVANNIA
YAR
TEQY
S
R
E
Q
IE
E
AAR
M
A
YAM
D
F
I
NK
M
DN
G
L
DT
V
I
GE
N
GV
L
LSGGQ
R
QRIAIARALL
RDSP
ILILDEATSA
L
D
TE
S
E
R
AIQ
A
AL
DELQ
K
N
RT
S
LVIAHRLSTI
E
K
ADEIVV
V
ED
G
V
IVERGTH
ND
LL
EHR
G
V
Y
A
Q
LH
K
M
Q
FG
fig|481805.3.peg.2882
Escherichia coli ATCC 8739 (11-581/582)
Q
TFRRL
------
W
PTIAPFKA
G
L
IVA
GVAL
-
IL
NA
A
SDTF
ML
S
L
LK
P
----LLD
DG
FGK---
T
DRS
VL
V
W
M
P
LV
V
I
GL
MI
----
L
RG
--
ITS
Y
VSS
Y
CI
S
W
V
SG-
-
--K
VV
MT
M
R
R
R
LFGHMM
GM
P
V
SFFD
K
Q
S
TG
T
L
L
SR
I
T
Y
D
S
E
-------
Q
V
A
SSSSGALI
TVVR
EG
A
SI
I
G
---
L
F
I
MMF
YY
SWQL
-
SI
I
L
I
V
L
A
P
I
VS
I
AI
------
R
VVSK
RFR
NIS
K
NMQ
N
T
MG
QVTT
S
AEQ
M
LK
G
HKE
V
LI
FG
GQEVETKRFDK
VSN
R
MRLQ-----------G
M
K
MV
S
A
S
S
-
IS
DP
I
I
Q
L
IA
SLAL
--
AF
V
L
Y
A
A
S
FPS
V
M
D
SLT
A
G
T
I
T
V
V
F
S
SMI
A
L
MR
PL
KS
LT
NV
-------
N
A
QF
QR
GM
AA
CQTL
F
T
I
L
D
S
E
Q
EK
------
DEGK
R
VIE
R
A
T
G
DVE
FR
NV
T
FTYP
GR
D
V
PAL
R
NINL
K
IP
A
G
KT
VALVG
R
S
GSGKST
I
ASLI
T
R
F
YD
I
D
EGEI
L
M
DG
H
D
L
RE
Y
T
L
A
SLR
NQ
VA
L
VSQ
N
V
H
LF
N
DTVANNIA
YAR
TEQY
S
R
E
Q
IE
E
AAR
M
A
YAM
D
F
I
NK
M
DN
G
L
DT
V
I
GE
N
GV
L
LSGGQ
R
QRIAIARALL
RDSP
ILILDEATSA
L
D
TE
S
E
R
AIQ
A
AL
DELQ
K
N
RT
S
LVIAHRLSTI
E
K
ADEIVV
V
ED
G
V
IVERGTH
ND
LL
EHR
G
V
Y
A
Q
LH
K
M
Q
FG
fig|481805.6.peg.2872
Escherichia coli ATCC 8739 (11-581/582)
Q
TFRRL
------
W
PTIAPFKA
G
L
IVA
GVAL
-
IL
NA
A
SDTF
ML
S
L
LK
P
----LLD
DG
FGK---
T
DRS
VL
V
W
M
P
LV
V
I
GL
MI
----
L
RG
--
ITS
Y
VSS
Y
CI
S
W
V
SG-
-
--K
VV
MT
M
R
R
R
LFGHMM
GM
P
V
SFFD
K
Q
S
TG
T
L
L
SR
I
T
Y
D
S
E
-------
Q
V
A
SSSSGALI
TVVR
EG
A
SI
I
G
---
L
F
I
MMF
YY
SWQL
-
SI
I
L
I
V
L
A
P
I
VS
I
AI
------
R
VVSK
RFR
NIS
K
NMQ
N
T
MG
QVTT
S
AEQ
M
LK
G
HKE
V
LI
FG
GQEVETKRFDK
VSN
R
MRLQ-----------G
M
K
MV
S
A
S
S
-
IS
DP
I
I
Q
L
IA
SLAL
--
AF
V
L
Y
A
A
S
FPS
V
M
D
SLT
A
G
T
I
T
V
V
F
S
SMI
A
L
MR
PL
KS
LT
NV
-------
N
A
QF
QR
GM
AA
CQTL
F
T
I
L
D
S
E
Q
EK
------
DEGK
R
VIE
R
A
T
G
DVE
FR
NV
T
FTYP
GR
D
V
PAL
R
NINL
K
IP
A
G
KT
VALVG
R
S
GSGKST
I
ASLI
T
R
F
YD
I
D
EGEI
L
M
DG
H
D
L
RE
Y
T
L
A
SLR
NQ
VA
L
VSQ
N
V
H
LF
N
DTVANNIA
YAR
TEQY
S
R
E
Q
IE
E
AAR
M
A
YAM
D
F
I
NK
M
DN
G
L
DT
V
I
GE
N
GV
L
LSGGQ
R
QRIAIARALL
RDSP
ILILDEATSA
L
D
TE
S
E
R
AIQ
A
AL
DELQ
K
N
RT
S
LVIAHRLSTI
E
K
ADEIVV
V
ED
G
V
IVERGTH
ND
LL
EHR
G
V
Y
A
Q
LH
K
M
Q
FG
fig|413997.3.peg.962
Escherichia coli B str. REL606 (11-581/582)
Q
TFRRL
------
W
PTIAPFKA
G
L
IVA
GVAL
-
IL
NA
A
SDTF
ML
S
L
LK
P
----LLD
DG
FGK---
T
DRS
VL
V
W
M
P
LV
V
I
GL
MI
----
L
RG
--
ITS
Y
VSS
Y
CI
S
W
V
SG-
-
--K
VV
MT
M
R
R
R
LFGHMM
GM
P
V
SFFD
K
Q
S
TG
T
L
L
SR
I
T
Y
D
S
E
-------
Q
V
A
SSSSGALI
TVVR
EG
A
SI
I
G
---
L
F
I
MMF
YY
SWQL
-
SI
I
L
I
V
L
A
P
I
VS
I
AI
------
R
VVSK
RFR
NIS
K
NMQ
N
T
MG
QVTT
S
AEQ
M
LK
G
HKE
V
LI
FG
GQEVETKRFDK
VSN
R
MRLQ-----------G
M
K
MV
S
A
S
S
-
IS
DP
I
I
Q
L
IA
SLAL
--
AF
V
L
Y
A
A
S
FPS
V
M
D
SLT
A
G
T
I
T
V
V
F
S
SMI
A
L
MR
PL
KS
LT
NV
-------
N
A
QF
QR
GM
AA
CQTL
F
T
I
L
D
S
E
Q
EK
------
DEGK
R
VIE
R
A
T
G
DVE
FR
NV
T
FTYP
GR
D
V
PAL
R
NINL
K
IP
A
G
KT
VALVG
R
S
GSGKST
I
ASLI
T
R
F
YD
I
D
EGEI
L
M
DG
H
D
L
RE
Y
T
L
A
SLR
NQ
VA
L
VSQ
N
V
H
LF
N
DTVANNIA
YAR
TEQY
S
R
E
Q
IE
E
AAR
M
A
YAM
D
F
I
NK
M
DN
G
L
DT
V
I
GE
N
GV
L
LSGGQ
R
QRIAIARALL
RDSP
ILILDEATSA
L
D
TE
S
E
R
AIQ
A
AL
DELQ
K
N
RT
S
LVIAHRLSTI
E
K
ADEIVV
V
ED
G
V
IVERGTH
ND
LL
EHR
G
V
Y
A
Q
LH
K
M
Q
FG
fig|550676.3.peg.383
Escherichia coli B185 (11-581/582)
Q
TFRRL
------
W
PTIAPFKA
G
L
IVA
GVAL
-
IL
NA
A
SDTF
ML
S
L
LK
P
----LLD
DG
FGK---
T
DRS
VL
V
W
M
P
LV
V
I
GL
MI
----
L
RG
--
ITS
Y
VSS
Y
CI
S
W
V
SG-
-
--K
VV
MT
M
R
R
R
LFGHMM
GM
P
V
SFFD
K
Q
S
TG
T
L
L
SR
I
T
Y
D
S
E
-------
Q
V
A
SSSSGALI
TVVR
EG
A
SI
I
G
---
L
F
I
MMF
YY
SWQL
-
SI
I
L
I
V
L
A
P
I
VS
I
AI
------
R
VVSK
RFR
NIS
K
NMQ
N
T
MG
QVTT
S
AEQ
M
LK
G
HKE
V
LI
FG
GQEVETKRFDK
VSN
R
MRLQ-----------G
M
K
MV
S
A
S
S
-
IS
DP
I
I
Q
L
IA
SLAL
--
AF
V
L
Y
A
A
S
FPS
V
M
D
SLT
A
G
T
I
T
V
V
F
S
SMI
A
L
MR
PL
KS
LT
NV
-------
N
A
QF
QR
GM
AA
CQTL
F
T
I
L
D
S
E
Q
EK
------
DEGK
R
VIE
R
A
T
G
DVE
FR
NV
T
FTYP
GR
D
V
PAL
R
NINL
K
IP
A
G
KT
VALVG
R
S
GSGKST
I
ASLI
T
R
F
YD
I
D
EGEI
L
M
DG
H
D
L
RE
Y
T
L
A
SLR
NQ
VA
L
VSQ
N
V
H
LF
N
DTVANNIA
YAR
TEQY
S
R
E
Q
IE
E
AAR
M
A
YAM
D
F
I
NK
M
DN
G
L
DT
V
I
GE
N
GV
L
LSGGQ
R
QRIAIARALL
RDSP
ILILDEATSA
L
D
TE
S
E
R
AIQ
A
AL
DELQ
K
N
RT
S
LVIAHRLSTI
E
K
ADEIVV
V
ED
G
V
IVERGTH
ND
LL
EHR
G
V
Y
A
Q
LH
K
M
Q
FG
fig|550677.3.peg.2188
Escherichia coli B354 (11-581/582)
Q
TFRRL
------
W
PTIAPFKA
G
L
IVA
GVAL
-
IL
NA
A
SDTF
ML
S
L
LK
P
----LLD
DG
FGK---
T
DRS
VL
V
W
M
P
LV
V
I
GL
MI
----
L
RG
--
ITS
Y
VSS
Y
CI
S
W
V
SG-
-
--K
VV
MT
M
R
R
R
LFGHMM
GM
P
V
SFFD
K
Q
S
TG
T
L
L
SR
I
T
Y
D
S
E
-------
Q
V
A
SSSSGALI
TVVR
EG
A
SI
I
G
---
L
F
I
MMF
YY
SWQL
-
SI
I
L
I
V
L
A
P
I
VS
I
AI
------
R
VVSK
RFR
NIS
K
NMQ
N
T
MG
QVTT
S
AEQ
M
LK
G
HKE
V
LI
FG
GQEVETKRFDK
VSN
R
MRLQ-----------G
M
K
MV
S
A
S
S
-
IS
DP
I
I
Q
L
IA
SLAL
--
AF
V
L
Y
A
A
S
FPS
V
M
D
SLT
A
G
T
I
T
V
V
F
S
SMI
A
L
MR
PL
KS
LT
NV
-------
N
A
QF
QR
GM
AA
CQTL
F
T
I
L
D
S
E
Q
EK
------
DEGK
R
VIE
R
A
T
G
DVE
FR
NV
T
FTYP
GR
D
V
PAL
R
NINL
K
IP
A
G
KT
VALVG
R
S
GSGKST
I
ASLI
T
R
F
YD
I
D
EGEI
L
M
DG
H
D
L
RE
Y
T
L
A
SLR
NQ
VA
L
VSQ
N
V
H
LF
N
DTVANNIA
YAR
TEQY
S
R
E
Q
IE
E
AAR
M
A
YAM
D
F
I
NK
M
DN
G
L
DT
V
I
GE
N
GV
L
LSGGQ
R
QRIAIARALL
RDSP
ILILDEATSA
L
D
TE
S
E
R
AIQ
A
AL
DELQ
K
N
RT
S
LVIAHRLSTI
E
K
ADEIVV
V
ED
G
V
IVERGTH
ND
LL
EHR
G
V
Y
A
Q
LH
K
M
Q
FG
fig|340184.3.peg.2071
Escherichia coli B7A (11-581/582)
Q
TFRRL
------
W
PTIAPFKA
G
L
IVA
GVAL
-
IL
NA
A
SDTF
ML
S
L
LK
P
----LLD
DG
FGK---
T
DRS
VL
V
W
M
P
LV
V
I
GL
MI
----
L
RG
--
ITS
Y
VSS
Y
CI
S
W
V
SG-
-
--K
VV
MT
M
R
R
R
LFGHMM
GM
P
V
SFFD
K
Q
S
TG
T
L
L
SR
I
T
Y
D
S
E
-------
Q
V
A
SSSSGALI
TVVR
EG
A
SI
I
G
---
L
F
I
MMF
YY
SWQL
-
SI
I
L
I
V
L
A
P
I
VS
I
AI
------
R
VVSK
RFR
NIS
K
NMQ
N
T
MG
QVTT
S
AEQ
M
LK
G
HKE
V
LI
FG
GQEVETKRFDK
VSN
R
MRLQ-----------G
M
K
MV
S
A
S
S
-
IS
DP
I
I
Q
L
IA
SLAL
--
AF
V
L
Y
A
A
S
FPS
V
M
D
SLT
A
G
T
I
T
V
V
F
S
SMI
A
L
MR
PL
KS
LT
NV
-------
N
A
QF
QR
GM
AA
CQTL
F
T
I
L
D
S
E
Q
EK
------
DEGK
R
VIE
R
A
T
G
DVE
FR
NV
T
FTYP
GR
D
V
PAL
R
NINL
K
IP
A
G
KT
VALVG
R
S
GSGKST
I
ASLI
T
R
F
YD
I
D
EGEI
L
M
DG
H
D
L
RE
Y
T
L
A
SLR
NQ
VA
L
VSQ
N
V
H
LF
N
DTVANNIA
YAR
TEQY
S
R
E
Q
IE
E
AAR
M
A
YAM
D
F
I
NK
M
DN
G
L
DT
V
I
GE
N
GV
L
LSGGQ
R
QRIAIARALL
RDSP
ILILDEATSA
L
D
TE
S
E
R
AIQ
A
AL
DELQ
K
N
RT
S
LVIAHRLSTI
E
K
ADEIVV
V
ED
G
V
IVERGTH
ND
LL
EHR
G
V
Y
A
Q
LH
K
M
Q
FG
fig|340184.6.peg.2177
Escherichia coli B7A (11-581/582)
Q
TFRRL
------
W
PTIAPFKA
G
L
IVA
GVAL
-
IL
NA
A
SDTF
ML
S
L
LK
P
----LLD
DG
FGK---
T
DRS
VL
V
W
M
P
LV
V
I
GL
MI
----
L
RG
--
ITS
Y
VSS
Y
CI
S
W
V
SG-
-
--K
VV
MT
M
R
R
R
LFGHMM
GM
P
V
SFFD
K
Q
S
TG
T
L
L
SR
I
T
Y
D
S
E
-------
Q
V
A
SSSSGALI
TVVR
EG
A
SI
I
G
---
L
F
I
MMF
YY
SWQL
-
SI
I
L
I
V
L
A
P
I
VS
I
AI
------
R
VVSK
RFR
NIS
K
NMQ
N
T
MG
QVTT
S
AEQ
M
LK
G
HKE
V
LI
FG
GQEVETKRFDK
VSN
R
MRLQ-----------G
M
K
MV
S
A
S
S
-
IS
DP
I
I
Q
L
IA
SLAL
--
AF
V
L
Y
A
A
S
FPS
V
M
D
SLT
A
G
T
I
T
V
V
F
S
SMI
A
L
MR
PL
KS
LT
NV
-------
N
A
QF
QR
GM
AA
CQTL
F
T
I
L
D
S
E
Q
EK
------
DEGK
R
VIE
R
A
T
G
DVE
FR
NV
T
FTYP
GR
D
V
PAL
R
NINL
K
IP
A
G
KT
VALVG
R
S
GSGKST
I
ASLI
T
R
F
YD
I
D
EGEI
L
M
DG
H
D
L
RE
Y
T
L
A
SLR
NQ
VA
L
VSQ
N
V
H
LF
N
DTVANNIA
YAR
TEQY
S
R
E
Q
IE
E
AAR
M
A
YAM
D
F
I
NK
M
DN
G
L
DT
V
I
GE
N
GV
L
LSGGQ
R
QRIAIARALL
RDSP
ILILDEATSA
L
D
TE
S
E
R
AIQ
A
AL
DELQ
K
N
RT
S
LVIAHRLSTI
E
K
ADEIVV
V
ED
G
V
IVERGTH
ND
LL
EHR
G
V
Y
A
Q
LH
K
M
Q
FG
fig|511693.5.peg.987
Escherichia coli BL21 (11-581/582)
Q
TFRRL
------
W
PTIAPFKA
G
L
IVA
GVAL
-
IL
NA
A
SDTF
ML
S
L
LK
P
----LLD
DG
FGK---
T
DRS
VL
V
W
M
P
LV
V
I
GL
MI
----
L
RG
--
ITS
Y
VSS
Y
CI
S
W
V
SG-
-
--K
VV
MT
M
R
R
R
LFGHMM
GM
P
V
SFFD
K
Q
S
TG
T
L
L
SR
I
T
Y
D
S
E
-------
Q
V
A
SSSSGALI
TVVR
EG
A
SI
I
G
---
L
F
I
MMF
YY
SWQL
-
SI
I
L
I
V
L
A
P
I
VS
I
AI
------
R
VVSK
RFR
NIS
K
NMQ
N
T
MG
QVTT
S
AEQ
M
LK
G
HKE
V
LI
FG
GQEVETKRFDK
VSN
R
MRLQ-----------G
M
K
MV
S
A
S
S
-
IS
DP
I
I
Q
L
IA
SLAL
--
AF
V
L
Y
A
A
S
FPS
V
M
D
SLT
A
G
T
I
T
V
V
F
S
SMI
A
L
MR
PL
KS
LT
NV
-------
N
A
QF
QR
GM
AA
CQTL
F
T
I
L
D
S
E
Q
EK
------
DEGK
R
VIE
R
A
T
G
DVE
FR
NV
T
FTYP
GR
D
V
PAL
R
NINL
K
IP
A
G
KT
VALVG
R
S
GSGKST
I
ASLI
T
R
F
YD
I
D
EGEI
L
M
DG
H
D
L
RE
Y
T
L
A
SLR
NQ
VA
L
VSQ
N
V
H
LF
N
DTVANNIA
YAR
TEQY
S
R
E
Q
IE
E
AAR
M
A
YAM
D
F
I
NK
M
DN
G
L
DT
V
I
GE
N
GV
L
LSGGQ
R
QRIAIARALL
RDSP
ILILDEATSA
L
D
TE
S
E
R
AIQ
A
AL
DELQ
K
N
RT
S
LVIAHRLSTI
E
K
ADEIVV
V
ED
G
V
IVERGTH
ND
LL
EHR
G
V
Y
A
Q
LH
K
M
Q
FG
fig|469008.4.peg.2775
Escherichia coli BL21(DE3) (11-581/582)
Q
TFRRL
------
W
PTIAPFKA
G
L
IVA
GVAL
-
IL
NA
A
SDTF
ML
S
L
LK
P
----LLD
DG
FGK---
T
DRS
VL
V
W
M
P
LV
V
I
GL
MI
----
L
RG
--
ITS
Y
VSS
Y
CI
S
W
V
SG-
-
--K
VV
MT
M
R
R
R
LFGHMM
GM
P
V
SFFD
K
Q
S
TG
T
L
L
SR
I
T
Y
D
S
E
-------
Q
V
A
SSSSGALI
TVVR
EG
A
SI
I
G
---
L
F
I
MMF
YY
SWQL
-
SI
I
L
I
V
L
A
P
I
VS
I
AI
------
R
VVSK
RFR
NIS
K
NMQ
N
T
MG
QVTT
S
AEQ
M
LK
G
HKE
V
LI
FG
GQEVETKRFDK
VSN
R
MRLQ-----------G
M
K
MV
S
A
S
S
-
IS
DP
I
I
Q
L
IA
SLAL
--
AF
V
L
Y
A
A
S
FPS
V
M
D
SLT
A
G
T
I
T
V
V
F
S
SMI
A
L
MR
PL
KS
LT
NV
-------
N
A
QF
QR
GM
AA
CQTL
F
T
I
L
D
S
E
Q
EK
------
DEGK
R
VIE
R
A
T
G
DVE
FR
NV
T
FTYP
GR
D
V
PAL
R
NINL
K
IP
A
G
KT
VALVG
R
S
GSGKST
I
ASLI
T
R
F
YD
I
D
EGEI
L
M
DG
H
D
L
RE
Y
T
L
A
SLR
NQ
VA
L
VSQ
N
V
H
LF
N
DTVANNIA
YAR
TEQY
S
R
E
Q
IE
E
AAR
M
A
YAM
D
F
I
NK
M
DN
G
L
DT
V
I
GE
N
GV
L
LSGGQ
R
QRIAIARALL
RDSP
ILILDEATSA
L
D
TE
S
E
R
AIQ
A
AL
DELQ
K
N
RT
S
LVIAHRLSTI
E
K
ADEIVV
V
ED
G
V
IVERGTH
ND
LL
EHR
G
V
Y
A
Q
LH
K
M
Q
FG
fig|595496.3.peg.844
Escherichia coli BW2952 (11-581/582)
Q
TFRRL
------
W
PTIAPFKA
G
L
IVA
GVAL
-
IL
NA
A
SDTF
ML
S
L
LK
P
----LLD
DG
FGK---
T
DRS
VL
V
W
M
P
LV
V
I
GL
MI
----
L
RG
--
ITS
Y
VSS
Y
CI
S
W
V
SG-
-
--K
VV
MT
M
R
R
R
LFGHMM
GM
P
V
SFFD
K
Q
S
TG
T
L
L
SR
I
T
Y
D
S
E
-------
Q
V
A
SSSSGALI
TVVR
EG
A
SI
I
G
---
L
F
I
MMF
YY
SWQL
-
SI
I
L
I
V
L
A
P
I
VS
I
AI
------
R
VVSK
RFR
NIS
K
NMQ
N
T
MG
QVTT
S
AEQ
M
LK
G
HKE
V
LI
FG
GQEVETKRFDK
VSN
R
MRLQ-----------G
M
K
MV
S
A
S
S
-
IS
DP
I
I
Q
L
IA
SLAL
--
AF
V
L
Y
A
A
S
FPS
V
M
D
SLT
A
G
T
I
T
V
V
F
S
SMI
A
L
MR
PL
KS
LT
NV
-------
N
A
QF
QR
GM
AA
CQTL
F
T
I
L
D
S
E
Q
EK
------
DEGK
R
VIE
R
A
T
G
DVE
FR
NV
T
FTYP
GR
D
V
PAL
R
NINL
K
IP
A
G
KT
VALVG
R
S
GSGKST
I
ASLI
T
R
F
YD
I
D
EGEI
L
M
DG
H
D
L
RE
Y
T
L
A
SLR
NQ
VA
L
VSQ
N
V
H
LF
N
DTVANNIA
YAR
TEQY
S
R
E
Q
IE
E
AAR
M
A
YAM
D
F
I
NK
M
DN
G
L
DT
V
I
GE
N
GV
L
LSGGQ
R
QRIAIARALL
RDSP
ILILDEATSA
L
D
TE
S
E
R
AIQ
A
AL
DELQ
K
N
RT
S
LVIAHRLSTI
E
K
ADEIVV
V
ED
G
V
IVERGTH
ND
LL
EHR
G
V
Y
A
Q
LH
K
M
Q
FG
fig|536056.3.peg.2881
Escherichia coli DH1 (11-581/582)
Q
TFRRL
------
W
PTIAPFKA
G
L
IVA
GVAL
-
IL
NA
A
SDTF
ML
S
L
LK
P
----LLD
DG
FGK---
T
DRS
VL
V
W
M
P
LV
V
I
GL
MI
----
L
RG
--
ITS
Y
VSS
Y
CI
S
W
V
SG-
-
--K
VV
MT
M
R
R
R
LFGHMM
GM
P
V
SFFD
K
Q
S
TG
T
L
L
SR
I
T
Y
D
S
E
-------
Q
V
A
SSSSGALI
TVVR
EG
A
SI
I
G
---
L
F
I
MMF
YY
SWQL
-
SI
I
L
I
V
L
A
P
I
VS
I
AI
------
R
VVSK
RFR
NIS
K
NMQ
N
T
MG
QVTT
S
AEQ
M
LK
G
HKE
V
LI
FG
GQEVETKRFDK
VSN
R
MRLQ-----------G
M
K
MV
S
A
S
S
-
IS
DP
I
I
Q
L
IA
SLAL
--
AF
V
L
Y
A
A
S
FPS
V
M
D
SLT
A
G
T
I
T
V
V
F
S
SMI
A
L
MR
PL
KS
LT
NV
-------
N
A
QF
QR
GM
AA
CQTL
F
T
I
L
D
S
E
Q
EK
------
DEGK
R
VIE
R
A
T
G
DVE
FR
NV
T
FTYP
GR
D
V
PAL
R
NINL
K
IP
A
G
KT
VALVG
R
S
GSGKST
I
ASLI
T
R
F
YD
I
D
EGEI
L
M
DG
H
D
L
RE
Y
T
L
A
SLR
NQ
VA
L
VSQ
N
V
H
LF
N
DTVANNIA
YAR
TEQY
S
R
E
Q
IE
E
AAR
M
A
YAM
D
F
I
NK
M
DN
G
L
DT
V
I
GE
N
GV
L
LSGGQ
R
QRIAIARALL
RDSP
ILILDEATSA
L
D
TE
S
E
R
AIQ
A
AL
DELQ
K
N
RT
S
LVIAHRLSTI
E
K
ADEIVV
V
ED
G
V
IVERGTH
ND
LL
EHR
G
V
Y
A
Q
LH
K
M
Q
FG
fig|340186.3.peg.3954
Escherichia coli E110019 (11-581/582)
Q
TFRRL
------
W
PTIAPFKA
G
L
IVA
GVAL
-
IL
NA
A
SDTF
ML
S
L
LK
P
----LLD
DG
FGK---
T
DRS
VL
V
W
M
P
LV
V
I
GL
MI
----
L
RG
--
ITS
Y
VSS
Y
CI
S
W
V
SG-
-
--K
VV
MT
M
R
R
R
LFGHMM
GM
P
V
SFFD
K
Q
S
TG
T
L
L
SR
I
T
Y
D
S
E
-------
Q
V
A
SSSSGALI
TVVR
EG
A
SI
I
G
---
L
F
I
MMF
YY
SWQL
-
SI
I
L
I
V
L
A
P
I
VS
I
AI
------
R
VVSK
RFR
NIS
K
NMQ
N
T
MG
QVTT
S
AEQ
M
LK
G
HKE
V
LI
FG
GQEVETKRFDK
VSN
R
MRLQ-----------G
M
K
MV
S
A
S
S
-
IS
DP
I
I
Q
L
IA
SLAL
--
AF
V
L
Y
A
A
S
FPS
V
M
D
SLT
A
G
T
I
T
V
V
F
S
SMI
A
L
MR
PL
KS
LT
NV
-------
N
A
QF
QR
GM
AA
CQTL
F
T
I
L
D
S
E
Q
EK
------
DEGK
R
VIE
R
A
T
G
DVE
FR
NV
T
FTYP
GR
D
V
PAL
R
NINL
K
IP
A
G
KT
VALVG
R
S
GSGKST
I
ASLI
T
R
F
YD
I
D
EGEI
L
M
DG
H
D
L
RE
Y
T
L
A
SLR
NQ
VA
L
VSQ
N
V
H
LF
N
DTVANNIA
YAR
TEQY
S
R
E
Q
IE
E
AAR
M
A
YAM
D
F
I
NK
M
DN
G
L
DT
V
I
GE
N
GV
L
LSGGQ
R
QRIAIARALL
RDSP
ILILDEATSA
L
D
TE
S
E
R
AIQ
A
AL
DELQ
K
N
RT
S
LVIAHRLSTI
E
K
ADEIVV
V
ED
G
V
IVERGTH
ND
LL
EHR
G
V
Y
A
Q
LH
K
M
Q
FG
fig|340186.5.peg.4157
Escherichia coli E110019 (11-581/582)
Q
TFRRL
------
W
PTIAPFKA
G
L
IVA
GVAL
-
IL
NA
A
SDTF
ML
S
L
LK
P
----LLD
DG
FGK---
T
DRS
VL
V
W
M
P
LV
V
I
GL
MI
----
L
RG
--
ITS
Y
VSS
Y
CI
S
W
V
SG-
-
--K
VV
MT
M
R
R
R
LFGHMM
GM
P
V
SFFD
K
Q
S
TG
T
L
L
SR
I
T
Y
D
S
E
-------
Q
V
A
SSSSGALI
TVVR
EG
A
SI
I
G
---
L
F
I
MMF
YY
SWQL
-
SI
I
L
I
V
L
A
P
I
VS
I
AI
------
R
VVSK
RFR
NIS
K
NMQ
N
T
MG
QVTT
S
AEQ
M
LK
G
HKE
V
LI
FG
GQEVETKRFDK
VSN
R
MRLQ-----------G
M
K
MV
S
A
S
S
-
IS
DP
I
I
Q
L
IA
SLAL
--
AF
V
L
Y
A
A
S
FPS
V
M
D
SLT
A
G
T
I
T
V
V
F
S
SMI
A
L
MR
PL
KS
LT
NV
-------
N
A
QF
QR
GM
AA
CQTL
F
T
I
L
D
S
E
Q
EK
------
DEGK
R
VIE
R
A
T
G
DVE
FR
NV
T
FTYP
GR
D
V
PAL
R
NINL
K
IP
A
G
KT
VALVG
R
S
GSGKST
I
ASLI
T
R
F
YD
I
D
EGEI
L
M
DG
H
D
L
RE
Y
T
L
A
SLR
NQ
VA
L
VSQ
N
V
H
LF
N
DTVANNIA
YAR
TEQY
S
R
E
Q
IE
E
AAR
M
A
YAM
D
F
I
NK
M
DN
G
L
DT
V
I
GE
N
GV
L
LSGGQ
R
QRIAIARALL
RDSP
ILILDEATSA
L
D
TE
S
E
R
AIQ
A
AL
DELQ
K
N
RT
S
LVIAHRLSTI
E
K
ADEIVV
V
ED
G
V
IVERGTH
ND
LL
EHR
G
V
Y
A
Q
LH
K
M
Q
FG
fig|331111.12.peg.1301
Escherichia coli E24377A (11-581/582)
Q
TFRRL
------
W
PTIAPFKA
G
L
IVA
GVAL
-
IL
NA
A
SDTF
ML
S
L
LK
P
----LLD
DG
FGK---
T
DRS
VL
V
W
M
P
LV
V
I
GL
MI
----
L
RG
--
ITS
Y
VSS
Y
CI
S
W
V
SG-
-
--K
VV
MT
M
R
R
R
LFGHMM
GM
P
V
SFFD
K
Q
S
TG
T
L
L
SR
I
T
Y
D
S
E
-------
Q
V
A
SSSSGALI
TVVR
EG
A
SI
I
G
---
L
F
I
MMF
YY
SWQL
-
SI
I
L
I
V
L
A
P
I
VS
I
AI
------
R
VVSK
RFR
NIS
K
NMQ
N
T
MG
QVTT
S
AEQ
M
LK
G
HKE
V
LI
FG
GQEVETKRFDK
VSN
R
MRLQ-----------G
M
K
MV
S
A
S
S
-
IS
DP
I
I
Q
L
IA
SLAL
--
AF
V
L
Y
A
A
S
FPS
V
M
D
SLT
A
G
T
I
T
V
V
F
S
SMI
A
L
MR
PL
KS
LT
NV
-------
N
A
QF
QR
GM
AA
CQTL
F
T
I
L
D
S
E
Q
EK
------
DEGK
R
VIE
R
A
T
G
DVE
FR
NV
T
FTYP
GR
D
V
PAL
R
NINL
K
IP
A
G
KT
VALVG
R
S
GSGKST
I
ASLI
T
R
F
YD
I
D
EGEI
L
M
DG
H
D
L
RE
Y
T
L
A
SLR
NQ
VA
L
VSQ
N
V
H
LF
N
DTVANNIA
YAR
TEQY
S
R
E
Q
IE
E
AAR
M
A
YAM
D
F
I
NK
M
DN
G
L
DT
V
I
GE
N
GV
L
LSGGQ
R
QRIAIARALL
RDSP
ILILDEATSA
L
D
TE
S
E
R
AIQ
A
AL
DELQ
K
N
RT
S
LVIAHRLSTI
E
K
ADEIVV
V
ED
G
V
IVERGTH
ND
LL
EHR
G
V
Y
A
Q
LH
K
M
Q
FG
fig|331111.3.peg.3504
Escherichia coli E24377A (11-581/582)
Q
TFRRL
------
W
PTIAPFKA
G
L
IVA
GVAL
-
IL
NA
A
SDTF
ML
S
L
LK
P
----LLD
DG
FGK---
T
DRS
VL
V
W
M
P
LV
V
I
GL
MI
----
L
RG
--
ITS
Y
VSS
Y
CI
S
W
V
SG-
-
--K
VV
MT
M
R
R
R
LFGHMM
GM
P
V
SFFD
K
Q
S
TG
T
L
L
SR
I
T
Y
D
S
E
-------
Q
V
A
SSSSGALI
TVVR
EG
A
SI
I
G
---
L
F
I
MMF
YY
SWQL
-
SI
I
L
I
V
L
A
P
I
VS
I
AI
------
R
VVSK
RFR
NIS
K
NMQ
N
T
MG
QVTT
S
AEQ
M
LK
G
HKE
V
LI
FG
GQEVETKRFDK
VSN
R
MRLQ-----------G
M
K
MV
S
A
S
S
-
IS
DP
I
I
Q
L
IA
SLAL
--
AF
V
L
Y
A
A
S
FPS
V
M
D
SLT
A
G
T
I
T
V
V
F
S
SMI
A
L
MR
PL
KS
LT
NV
-------
N
A
QF
QR
GM
AA
CQTL
F
T
I
L
D
S
E
Q
EK
------
DEGK
R
VIE
R
A
T
G
DVE
FR
NV
T
FTYP
GR
D
V
PAL
R
NINL
K
IP
A
G
KT
VALVG
R
S
GSGKST
I
ASLI
T
R
F
YD
I
D
EGEI
L
M
DG
H
D
L
RE
Y
T
L
A
SLR
NQ
VA
L
VSQ
N
V
H
LF
N
DTVANNIA
YAR
TEQY
S
R
E
Q
IE
E
AAR
M
A
YAM
D
F
I
NK
M
DN
G
L
DT
V
I
GE
N
GV
L
LSGGQ
R
QRIAIARALL
RDSP
ILILDEATSA
L
D
TE
S
E
R
AIQ
A
AL
DELQ
K
N
RT
S
LVIAHRLSTI
E
K
ADEIVV
V
ED
G
V
IVERGTH
ND
LL
EHR
G
V
Y
A
Q
LH
K
M
Q
FG
fig|562.375.peg.4567
Escherichia coli EC4100B (11-581/582)
Q
TFRRL
------
W
PTIAPFKA
G
L
IVA
GVAL
-
IL
NA
A
SDTF
ML
S
L
LK
P
----LLD
DG
FGK---
T
DRS
VL
V
W
M
P
LV
V
I
GL
MI
----
L
RG
--
ITS
Y
VSS
Y
CI
S
W
V
SG-
-
--K
VV
MT
M
R
R
R
LFGHMM
GM
P
V
SFFD
K
Q
S
TG
T
L
L
SR
I
T
Y
D
S
E
-------
Q
V
A
SSSSGALI
TVVR
EG
A
SI
I
G
---
L
F
I
MMF
YY
SWQL
-
SI
I
L
I
V
L
A
P
I
VS
I
AI
------
R
VVSK
RFR
NIS
K
NMQ
N
T
MG
QVTT
S
AEQ
M
LK
G
HKE
V
LI
FG
GQEVETKRFDK
VSN
R
MRLQ-----------G
M
K
MV
S
A
S
S
-
IS
DP
I
I
Q
L
IA
SLAL
--
AF
V
L
Y
A
A
S
FPS
V
M
D
SLT
A
G
T
I
T
V
V
F
S
SMI
A
L
MR
PL
KS
LT
NV
-------
N
A
QF
QR
GM
AA
CQTL
F
T
I
L
D
S
E
Q
EK
------
DEGK
R
VIE
R
A
T
G
DVE
FR
NV
T
FTYP
GR
D
V
PAL
R
NINL
K
IP
A
G
KT
VALVG
R
S
GSGKST
I
ASLI
T
R
F
YD
I
D
EGEI
L
M
DG
H
D
L
RE
Y
T
L
A
SLR
NQ
VA
L
VSQ
N
V
H
LF
N
DTVANNIA
YAR
TEQY
S
R
E
Q
IE
E
AAR
M
A
YAM
D
F
I
NK
M
DN
G
L
DT
V
I
GE
N
GV
L
LSGGQ
R
QRIAIARALL
RDSP
ILILDEATSA
L
D
TE
S
E
R
AIQ
A
AL
DELQ
K
N
RT
S
LVIAHRLSTI
E
K
ADEIVV
V
ED
G
V
IVERGTH
ND
LL
EHR
G
V
Y
A
Q
LH
K
M
Q
FG
fig|656408.3.peg.977
Escherichia coli H591 (11-581/582)
Q
TFRRL
------
W
PTIAPFKA
G
L
IVA
GVAL
-
IL
NA
A
SDTF
ML
S
L
LK
P
----LLD
DG
FGK---
T
DRS
VL
V
W
M
P
LV
V
I
GL
MI
----
L
RG
--
ITS
Y
VSS
Y
CI
S
W
V
SG-
-
--K
VV
MT
M
R
R
R
LFGHMM
GM
P
V
SFFD
K
Q
S
TG
T
L
L
SR
I
T
Y
D
S
E
-------
Q
V
A
SSSSGALI
TVVR
EG
A
SI
I
G
---
L
F
I
MMF
YY
SWQL
-
SI
I
L
I
V
L
A
P
I
VS
I
AI
------
R
VVSK
RFR
NIS
K
NMQ
N
T
MG
QVTT
S
AEQ
M
LK
G
HKE
V
LI
FG
GQEVETKRFDK
VSN
R
MRLQ-----------G
M
K
MV
S
A
S
S
-
IS
DP
I
I
Q
L
IA
SLAL
--
AF
V
L
Y
A
A
S
FPS
V
M
D
SLT
A
G
T
I
T
V
V
F
S
SMI
A
L
MR
PL
KS
LT
NV
-------
N
A
QF
QR
GM
AA
CQTL
F
T
I
L
D
S
E
Q
EK
------
DEGK
R
VIE
R
A
T
G
DVE
FR
NV
T
FTYP
GR
D
V
PAL
R
NINL
K
IP
A
G
KT
VALVG
R
S
GSGKST
I
ASLI
T
R
F
YD
I
D
EGEI
L
M
DG
H
D
L
RE
Y
T
L
A
SLR
NQ
VA
L
VSQ
N
V
H
LF
N
DTVANNIA
YAR
TEQY
S
R
E
Q
IE
E
AAR
M
A
YAM
D
F
I
NK
M
DN
G
L
DT
V
I
GE
N
GV
L
LSGGQ
R
QRIAIARALL
RDSP
ILILDEATSA
L
D
TE
S
E
R
AIQ
A
AL
DELQ
K
N
RT
S
LVIAHRLSTI
E
K
ADEIVV
V
ED
G
V
IVERGTH
ND
LL
EHR
G
V
Y
A
Q
LH
K
M
Q
FG
fig|656414.3.peg.1130
Escherichia coli H736 (11-581/582)
Q
TFRRL
------
W
PTIAPFKA
G
L
IVA
GVAL
-
IL
NA
A
SDTF
ML
S
L
LK
P
----LLD
DG
FGK---
T
DRS
VL
V
W
M
P
LV
V
I
GL
MI
----
L
RG
--
ITS
Y
VSS
Y
CI
S
W
V
SG-
-
--K
VV
MT
M
R
R
R
LFGHMM
GM
P
V
SFFD
K
Q
S
TG
T
L
L
SR
I
T
Y
D
S
E
-------
Q
V
A
SSSSGALI
TVVR
EG
A
SI
I
G
---
L
F
I
MMF
YY
SWQL
-
SI
I
L
I
V
L
A
P
I
VS
I
AI
------
R
VVSK
RFR
NIS
K
NMQ
N
T
MG
QVTT
S
AEQ
M
LK
G
HKE
V
LI
FG
GQEVETKRFDK
VSN
R
MRLQ-----------G
M
K
MV
S
A
S
S
-
IS
DP
I
I
Q
L
IA
SLAL
--
AF
V
L
Y
A
A
S
FPS
V
M
D
SLT
A
G
T
I
T
V
V
F
S
SMI
A
L
MR
PL
KS
LT
NV
-------
N
A
QF
QR
GM
AA
CQTL
F
T
I
L
D
S
E
Q
EK
------
DEGK
R
VIE
R
A
T
G
DVE
FR
NV
T
FTYP
GR
D
V
PAL
R
NINL
K
IP
A
G
KT
VALVG
R
S
GSGKST
I
ASLI
T
R
F
YD
I
D
EGEI
L
M
DG
H
D
L
RE
Y
T
L
A
SLR
NQ
VA
L
VSQ
N
V
H
LF
N
DTVANNIA
YAR
TEQY
S
R
E
Q
IE
E
AAR
M
A
YAM
D
F
I
NK
M
DN
G
L
DT
V
I
GE
N
GV
L
LSGGQ
R
QRIAIARALL
RDSP
ILILDEATSA
L
D
TE
S
E
R
AIQ
A
AL
DELQ
K
N
RT
S
LVIAHRLSTI
E
K
ADEIVV
V
ED
G
V
IVERGTH
ND
LL
EHR
G
V
Y
A
Q
LH
K
M
Q
FG
fig|331112.3.peg.950
Escherichia coli HS (11-581/582)
Q
TFRRL
------
W
PTIAPFKA
G
L
IVA
GVAL
-
IL
NA
A
SDTF
ML
S
L
LK
P
----LLD
DG
FGK---
T
DRS
VL
V
W
M
P
LV
V
I
GL
MI
----
L
RG
--
ITS
Y
VSS
Y
CI
S
W
V
SG-
-
--K
VV
MT
M
R
R
R
LFGHMM
GM
P
V
SFFD
K
Q
S
TG
T
L
L
SR
I
T
Y
D
S
E
-------
Q
V
A
SSSSGALI
TVVR
EG
A
SI
I
G
---
L
F
I
MMF
YY
SWQL
-
SI
I
L
I
V
L
A
P
I
VS
I
AI
------
R
VVSK
RFR
NIS
K
NMQ
N
T
MG
QVTT
S
AEQ
M
LK
G
HKE
V
LI
FG
GQEVETKRFDK
VSN
R
MRLQ-----------G
M
K
MV
S
A
S
S
-
IS
DP
I
I
Q
L
IA
SLAL
--
AF
V
L
Y
A
A
S
FPS
V
M
D
SLT
A
G
T
I
T
V
V
F
S
SMI
A
L
MR
PL
KS
LT
NV
-------
N
A
QF
QR
GM
AA
CQTL
F
T
I
L
D
S
E
Q
EK
------
DEGK
R
VIE
R
A
T
G
DVE
FR
NV
T
FTYP
GR
D
V
PAL
R
NINL
K
IP
A
G
KT
VALVG
R
S
GSGKST
I
ASLI
T
R
F
YD
I
D
EGEI
L
M
DG
H
D
L
RE
Y
T
L
A
SLR
NQ
VA
L
VSQ
N
V
H
LF
N
DTVANNIA
YAR
TEQY
S
R
E
Q
IE
E
AAR
M
A
YAM
D
F
I
NK
M
DN
G
L
DT
V
I
GE
N
GV
L
LSGGQ
R
QRIAIARALL
RDSP
ILILDEATSA
L
D
TE
S
E
R
AIQ
A
AL
DELQ
K
N
RT
S
LVIAHRLSTI
E
K
ADEIVV
V
ED
G
V
IVERGTH
ND
LL
EHR
G
V
Y
A
Q
LH
K
M
Q
FG
fig|331112.6.peg.989
Escherichia coli HS (11-581/582)
Q
TFRRL
------
W
PTIAPFKA
G
L
IVA
GVAL
-
IL
NA
A
SDTF
ML
S
L
LK
P
----LLD
DG
FGK---
T
DRS
VL
V
W
M
P
LV
V
I
GL
MI
----
L
RG
--
ITS
Y
VSS
Y
CI
S
W
V
SG-
-
--K
VV
MT
M
R
R
R
LFGHMM
GM
P
V
SFFD
K
Q
S
TG
T
L
L
SR
I
T
Y
D
S
E
-------
Q
V
A
SSSSGALI
TVVR
EG
A
SI
I
G
---
L
F
I
MMF
YY
SWQL
-
SI
I
L
I
V
L
A
P
I
VS
I
AI
------
R
VVSK
RFR
NIS
K
NMQ
N
T
MG
QVTT
S
AEQ
M
LK
G
HKE
V
LI
FG
GQEVETKRFDK
VSN
R
MRLQ-----------G
M
K
MV
S
A
S
S
-
IS
DP
I
I
Q
L
IA
SLAL
--
AF
V
L
Y
A
A
S
FPS
V
M
D
SLT
A
G
T
I
T
V
V
F
S
SMI
A
L
MR
PL
KS
LT
NV
-------
N
A
QF
QR
GM
AA
CQTL
F
T
I
L
D
S
E
Q
EK
------
DEGK
R
VIE
R
A
T
G
DVE
FR
NV
T
FTYP
GR
D
V
PAL
R
NINL
K
IP
A
G
KT
VALVG
R
S
GSGKST
I
ASLI
T
R
F
YD
I
D
EGEI
L
M
DG
H
D
L
RE
Y
T
L
A
SLR
NQ
VA
L
VSQ
N
V
H
LF
N
DTVANNIA
YAR
TEQY
S
R
E
Q
IE
E
AAR
M
A
YAM
D
F
I
NK
M
DN
G
L
DT
V
I
GE
N
GV
L
LSGGQ
R
QRIAIARALL
RDSP
ILILDEATSA
L
D
TE
S
E
R
AIQ
A
AL
DELQ
K
N
RT
S
LVIAHRLSTI
E
K
ADEIVV
V
ED
G
V
IVERGTH
ND
LL
EHR
G
V
Y
A
Q
LH
K
M
Q
FG
fig|585034.4.peg.945
Escherichia coli IAI1 (11-581/582)
Q
TFRRL
------
W
PTIAPFKA
G
L
IVA
GVAL
-
IL
NA
A
SDTF
ML
S
L
LK
P
----LLD
DG
FGK---
T
DRS
VL
V
W
M
P
LV
V
I
GL
MI
----
L
RG
--
ITS
Y
VSS
Y
CI
S
W
V
SG-
-
--K
VV
MT
M
R
R
R
LFGHMM
GM
P
V
SFFD
K
Q
S
TG
T
L
L
SR
I
T
Y
D
S
E
-------
Q
V
A
SSSSGALI
TVVR
EG
A
SI
I
G
---
L
F
I
MMF
YY
SWQL
-
SI
I
L
I
V
L
A
P
I
VS
I
AI
------
R
VVSK
RFR
NIS
K
NMQ
N
T
MG
QVTT
S
AEQ
M
LK
G
HKE
V
LI
FG
GQEVETKRFDK
VSN
R
MRLQ-----------G
M
K
MV
S
A
S
S
-
IS
DP
I
I
Q
L
IA
SLAL
--
AF
V
L
Y
A
A
S
FPS
V
M
D
SLT
A
G
T
I
T
V
V
F
S
SMI
A
L
MR
PL
KS
LT
NV
-------
N
A
QF
QR
GM
AA
CQTL
F
T
I
L
D
S
E
Q
EK
------
DEGK
R
VIE
R
A
T
G
DVE
FR
NV
T
FTYP
GR
D
V
PAL
R
NINL
K
IP
A
G
KT
VALVG
R
S
GSGKST
I
ASLI
T
R
F
YD
I
D
EGEI
L
M
DG
H
D
L
RE
Y
T
L
A
SLR
NQ
VA
L
VSQ
N
V
H
LF
N
DTVANNIA
YAR
TEQY
S
R
E
Q
IE
E
AAR
M
A
YAM
D
F
I
NK
M
DN
G
L
DT
V
I
GE
N
GV
L
LSGGQ
R
QRIAIARALL
RDSP
ILILDEATSA
L
D
TE
S
E
R
AIQ
A
AL
DELQ
K
N
RT
S
LVIAHRLSTI
E
K
ADEIVV
V
ED
G
V
IVERGTH
ND
LL
EHR
G
V
Y
A
Q
LH
K
M
Q
FG
fig|585034.5.peg.941
Escherichia coli IAI1 (11-581/582)
Q
TFRRL
------
W
PTIAPFKA
G
L
IVA
GVAL
-
IL
NA
A
SDTF
ML
S
L
LK
P
----LLD
DG
FGK---
T
DRS
VL
V
W
M
P
LV
V
I
GL
MI
----
L
RG
--
ITS
Y
VSS
Y
CI
S
W
V
SG-
-
--K
VV
MT
M
R
R
R
LFGHMM
GM
P
V
SFFD
K
Q
S
TG
T
L
L
SR
I
T
Y
D
S
E
-------
Q
V
A
SSSSGALI
TVVR
EG
A
SI
I
G
---
L
F
I
MMF
YY
SWQL
-
SI
I
L
I
V
L
A
P
I
VS
I
AI
------
R
VVSK
RFR
NIS
K
NMQ
N
T
MG
QVTT
S
AEQ
M
LK
G
HKE
V
LI
FG
GQEVETKRFDK
VSN
R
MRLQ-----------G
M
K
MV
S
A
S
S
-
IS
DP
I
I
Q
L
IA
SLAL
--
AF
V
L
Y
A
A
S
FPS
V
M
D
SLT
A
G
T
I
T
V
V
F
S
SMI
A
L
MR
PL
KS
LT
NV
-------
N
A
QF
QR
GM
AA
CQTL
F
T
I
L
D
S
E
Q
EK
------
DEGK
R
VIE
R
A
T
G
DVE
FR
NV
T
FTYP
GR
D
V
PAL
R
NINL
K
IP
A
G
KT
VALVG
R
S
GSGKST
I
ASLI
T
R
F
YD
I
D
EGEI
L
M
DG
H
D
L
RE
Y
T
L
A
SLR
NQ
VA
L
VSQ
N
V
H
LF
N
DTVANNIA
YAR
TEQY
S
R
E
Q
IE
E
AAR
M
A
YAM
D
F
I
NK
M
DN
G
L
DT
V
I
GE
N
GV
L
LSGGQ
R
QRIAIARALL
RDSP
ILILDEATSA
L
D
TE
S
E
R
AIQ
A
AL
DELQ
K
N
RT
S
LVIAHRLSTI
E
K
ADEIVV
V
ED
G
V
IVERGTH
ND
LL
EHR
G
V
Y
A
Q
LH
K
M
Q
FG
fig|585057.4.peg.2325
Escherichia coli IAI39 (11-581/582)
Q
TFRRL
------
W
PTIAPFKA
G
L
IVA
GVAL
-
IL
NA
A
SDTF
ML
S
L
LK
P
----LLD
DG
FGK---
T
DRS
VL
V
W
M
P
LV
V
I
GL
MI
----
L
RG
--
ITS
Y
VSS
Y
CI
S
W
V
SG-
-
--K
VV
MT
M
R
R
R
LFGHMM
GM
P
V
SFFD
K
Q
S
TG
T
L
L
SR
I
T
Y
D
S
E
-------
Q
V
A
SSSSGALI
TVVR
EG
A
SI
I
G
---
L
F
I
MMF
YY
SWQL
-
SI
I
L
I
V
L
A
P
I
VS
I
AI
------
R
VVSK
RFR
NIS
K
NMQ
N
T
MG
QVTT
S
AEQ
M
LK
G
HKE
V
LI
FG
GQEVETKRFDK
VSN
R
MRLQ-----------G
M
K
MV
S
A
S
S
-
IS
DP
I
I
Q
L
IA
SLAL
--
AF
V
L
Y
A
A
S
FPS
V
M
D
SLT
A
G
T
I
T
V
V
F
S
SMI
A
L
MR
PL
KS
LT
NV
-------
N
A
QF
QR
GM
AA
CQTL
F
T
I
L
D
S
E
Q
EK
------
DEGK
R
VIE
R
A
T
G
DVE
FR
NV
T
FTYP
GR
D
V
PAL
R
NINL
K
IP
A
G
KT
VALVG
R
S
GSGKST
I
ASLI
T
R
F
YD
I
D
EGEI
L
M
DG
H
D
L
RE
Y
T
L
A
SLR
NQ
VA
L
VSQ
N
V
H
LF
N
DTVANNIA
YAR
TEQY
S
R
E
Q
IE
E
AAR
M
A
YAM
D
F
I
NK
M
DN
G
L
DT
V
I
GE
N
GV
L
LSGGQ
R
QRIAIARALL
RDSP
ILILDEATSA
L
D
TE
S
E
R
AIQ
A
AL
DELQ
K
N
RT
S
LVIAHRLSTI
E
K
ADEIVV
V
ED
G
V
IVERGTH
ND
LL
EHR
G
V
Y
A
Q
LH
K
M
Q
FG
fig|585057.6.peg.2326
Escherichia coli IAI39 (11-581/582)
Q
TFRRL
------
W
PTIAPFKA
G
L
IVA
GVAL
-
IL
NA
A
SDTF
ML
S
L
LK
P
----LLD
DG
FGK---
T
DRS
VL
V
W
M
P
LV
V
I
GL
MI
----
L
RG
--
ITS
Y
VSS
Y
CI
S
W
V
SG-
-
--K
VV
MT
M
R
R
R
LFGHMM
GM
P
V
SFFD
K
Q
S
TG
T
L
L
SR
I
T
Y
D
S
E
-------
Q
V
A
SSSSGALI
TVVR
EG
A
SI
I
G
---
L
F
I
MMF
YY
SWQL
-
SI
I
L
I
V
L
A
P
I
VS
I
AI
------
R
VVSK
RFR
NIS
K
NMQ
N
T
MG
QVTT
S
AEQ
M
LK
G
HKE
V
LI
FG
GQEVETKRFDK
VSN
R
MRLQ-----------G
M
K
MV
S
A
S
S
-
IS
DP
I
I
Q
L
IA
SLAL
--
AF
V
L
Y
A
A
S
FPS
V
M
D
SLT
A
G
T
I
T
V
V
F
S
SMI
A
L
MR
PL
KS
LT
NV
-------
N
A
QF
QR
GM
AA
CQTL
F
T
I
L
D
S
E
Q
EK
------
DEGK
R
VIE
R
A
T
G
DVE
FR
NV
T
FTYP
GR
D
V
PAL
R
NINL
K
IP
A
G
KT
VALVG
R
S
GSGKST
I
ASLI
T
R
F
YD
I
D
EGEI
L
M
DG
H
D
L
RE
Y
T
L
A
SLR
NQ
VA
L
VSQ
N
V
H
LF
N
DTVANNIA
YAR
TEQY
S
R
E
Q
IE
E
AAR
M
A
YAM
D
F
I
NK
M
DN
G
L
DT
V
I
GE
N
GV
L
LSGGQ
R
QRIAIARALL
RDSP
ILILDEATSA
L
D
TE
S
E
R
AIQ
A
AL
DELQ
K
N
RT
S
LVIAHRLSTI
E
K
ADEIVV
V
ED
G
V
IVERGTH
ND
LL
EHR
G
V
Y
A
Q
LH
K
M
Q
FG
fig|83333.1.peg.899
Escherichia coli K12 (11-581/582)
Q
TFRRL
------
W
PTIAPFKA
G
L
IVA
GVAL
-
IL
NA
A
SDTF
ML
S
L
LK
P
----LLD
DG
FGK---
T
DRS
VL
V
W
M
P
LV
V
I
GL
MI
----
L
RG
--
ITS
Y
VSS
Y
CI
S
W
V
SG-
-
--K
VV
MT
M
R
R
R
LFGHMM
GM
P
V
SFFD
K
Q
S
TG
T
L
L
SR
I
T
Y
D
S
E
-------
Q
V
A
SSSSGALI
TVVR
EG
A
SI
I
G
---
L
F
I
MMF
YY
SWQL
-
SI
I
L
I
V
L
A
P
I
VS
I
AI
------
R
VVSK
RFR
NIS
K
NMQ
N
T
MG
QVTT
S
AEQ
M
LK
G
HKE
V
LI
FG
GQEVETKRFDK
VSN
R
MRLQ-----------G
M
K
MV
S
A
S
S
-
IS
DP
I
I
Q
L
IA
SLAL
--
AF
V
L
Y
A
A
S
FPS
V
M
D
SLT
A
G
T
I
T
V
V
F
S
SMI
A
L
MR
PL
KS
LT
NV
-------
N
A
QF
QR
GM
AA
CQTL
F
T
I
L
D
S
E
Q
EK
------
DEGK
R
VIE
R
A
T
G
DVE
FR
NV
T
FTYP
GR
D
V
PAL
R
NINL
K
IP
A
G
KT
VALVG
R
S
GSGKST
I
ASLI
T
R
F
YD
I
D
EGEI
L
M
DG
H
D
L
RE
Y
T
L
A
SLR
NQ
VA
L
VSQ
N
V
H
LF
N
DTVANNIA
YAR
TEQY
S
R
E
Q
IE
E
AAR
M
A
YAM
D
F
I
NK
M
DN
G
L
DT
V
I
GE
N
GV
L
LSGGQ
R
QRIAIARALL
RDSP
ILILDEATSA
L
D
TE
S
E
R
AIQ
A
AL
DELQ
K
N
RT
S
LVIAHRLSTI
E
K
ADEIVV
V
ED
G
V
IVERGTH
ND
LL
EHR
G
V
Y
A
Q
LH
K
M
Q
FG
fig|595495.4.peg.2314
Escherichia coli KO11 (11-581/582)
Q
TFRRL
------
W
PTIAPFKA
G
L
IVA
GVAL
-
IL
NA
A
SDTF
ML
S
L
LK
P
----LLD
DG
FGK---
T
DRS
VL
V
W
M
P
LV
V
I
GL
MI
----
L
RG
--
ITS
Y
VSS
Y
CI
S
W
V
SG-
-
--K
VV
MT
M
R
R
R
LFGHMM
GM
P
V
SFFD
K
Q
S
TG
T
L
L
SR
I
T
Y
D
S
E
-------
Q
V
A
SSSSGALI
TVVR
EG
A
SI
I
G
---
L
F
I
MMF
YY
SWQL
-
SI
I
L
I
V
L
A
P
I
VS
I
AI
------
R
VVSK
RFR
NIS
K
NMQ
N
T
MG
QVTT
S
AEQ
M
LK
G
HKE
V
LI
FG
GQEVETKRFDK
VSN
R
MRLQ-----------G
M
K
MV
S
A
S
S
-
IS
DP
I
I
Q
L
IA
SLAL
--
AF
V
L
Y
A
A
S
FPS
V
M
D
SLT
A
G
T
I
T
V
V
F
S
SMI
A
L
MR
PL
KS
LT
NV
-------
N
A
QF
QR
GM
AA
CQTL
F
T
I
L
D
S
E
Q
EK
------
DEGK
R
VIE
R
A
T
G
DVE
FR
NV
T
FTYP
GR
D
V
PAL
R
NINL
K
IP
A
G
KT
VALVG
R
S
GSGKST
I
ASLI
T
R
F
YD
I
D
EGEI
L
M
DG
H
D
L
RE
Y
T
L
A
SLR
NQ
VA
L
VSQ
N
V
H
LF
N
DTVANNIA
YAR
TEQY
S
R
E
Q
IE
E
AAR
M
A
YAM
D
F
I
NK
M
DN
G
L
DT
V
I
GE
N
GV
L
LSGGQ
R
QRIAIARALL
RDSP
ILILDEATSA
L
D
TE
S
E
R
AIQ
A
AL
DELQ
K
N
RT
S
LVIAHRLSTI
E
K
ADEIVV
V
ED
G
V
IVERGTH
ND
LL
EHR
G
V
Y
A
Q
LH
K
M
Q
FG
fig|656419.3.peg.1212
Escherichia coli M718 (11-581/582)
Q
TFRRL
------
W
PTIAPFKA
G
L
IVA
GVAL
-
IL
NA
A
SDTF
ML
S
L
LK
P
----LLD
DG
FGK---
T
DRS
VL
V
W
M
P
LV
V
I
GL
MI
----
L
RG
--
ITS
Y
VSS
Y
CI
S
W
V
SG-
-
--K
VV
MT
M
R
R
R
LFGHMM
GM
P
V
SFFD
K
Q
S
TG
T
L
L
SR
I
T
Y
D
S
E
-------
Q
V
A
SSSSGALI
TVVR
EG
A
SI
I
G
---
L
F
I
MMF
YY
SWQL
-
SI
I
L
I
V
L
A
P
I
VS
I
AI
------
R
VVSK
RFR
NIS
K
NMQ
N
T
MG
QVTT
S
AEQ
M
LK
G
HKE
V
LI
FG
GQEVETKRFDK
VSN
R
MRLQ-----------G
M
K
MV
S
A
S
S
-
IS
DP
I
I
Q
L
IA
SLAL
--
AF
V
L
Y
A
A
S
FPS
V
M
D
SLT
A
G
T
I
T
V
V
F
S
SMI
A
L
MR
PL
KS
LT
NV
-------
N
A
QF
QR
GM
AA
CQTL
F
T
I
L
D
S
E
Q
EK
------
DEGK
R
VIE
R
A
T
G
DVE
FR
NV
T
FTYP
GR
D
V
PAL
R
NINL
K
IP
A
G
KT
VALVG
R
S
GSGKST
I
ASLI
T
R
F
YD
I
D
EGEI
L
M
DG
H
D
L
RE
Y
T
L
A
SLR
NQ
VA
L
VSQ
N
V
H
LF
N
DTVANNIA
YAR
TEQY
S
R
E
Q
IE
E
AAR
M
A
YAM
D
F
I
NK
M
DN
G
L
DT
V
I
GE
N
GV
L
LSGGQ
R
QRIAIARALL
RDSP
ILILDEATSA
L
D
TE
S
E
R
AIQ
A
AL
DELQ
K
N
RT
S
LVIAHRLSTI
E
K
ADEIVV
V
ED
G
V
IVERGTH
ND
LL
EHR
G
V
Y
A
Q
LH
K
M
Q
FG
fig|679207.4.peg.1987
Escherichia coli MS 107-1 (11-581/582)
Q
TFRRL
------
W
PTIAPFKA
G
L
IVA
GVAL
-
IL
NA
A
SDTF
ML
S
L
LK
P
----LLD
DG
FGK---
T
DRS
VL
V
W
M
P
LV
V
I
GL
MI
----
L
RG
--
ITS
Y
VSS
Y
CI
S
W
V
SG-
-
--K
VV
MT
M
R
R
R
LFGHMM
GM
P
V
SFFD
K
Q
S
TG
T
L
L
SR
I
T
Y
D
S
E
-------
Q
V
A
SSSSGALI
TVVR
EG
A
SI
I
G
---
L
F
I
MMF
YY
SWQL
-
SI
I
L
I
V
L
A
P
I
VS
I
AI
------
R
VVSK
RFR
NIS
K
NMQ
N
T
MG
QVTT
S
AEQ
M
LK
G
HKE
V
LI
FG
GQEVETKRFDK
VSN
R
MRLQ-----------G
M
K
MV
S
A
S
S
-
IS
DP
I
I
Q
L
IA
SLAL
--
AF
V
L
Y
A
A
S
FPS
V
M
D
SLT
A
G
T
I
T
V
V
F
S
SMI
A
L
MR
PL
KS
LT
NV
-------
N
A
QF
QR
GM
AA
CQTL
F
T
I
L
D
S
E
Q
EK
------
DEGK
R
VIE
R
A
T
G
DVE
FR
NV
T
FTYP
GR
D
V
PAL
R
NINL
K
IP
A
G
KT
VALVG
R
S
GSGKST
I
ASLI
T
R
F
YD
I
D
EGEI
L
M
DG
H
D
L
RE
Y
T
L
A
SLR
NQ
VA
L
VSQ
N
V
H
LF
N
DTVANNIA
YAR
TEQY
S
R
E
Q
IE
E
AAR
M
A
YAM
D
F
I
NK
M
DN
G
L
DT
V
I
GE
N
GV
L
LSGGQ
R
QRIAIARALL
RDSP
ILILDEATSA
L
D
TE
S
E
R
AIQ
A
AL
DELQ
K
N
RT
S
LVIAHRLSTI
E
K
ADEIVV
V
ED
G
V
IVERGTH
ND
LL
EHR
G
V
Y
A
Q
LH
K
M
Q
FG
fig|749537.3.peg.4514
Escherichia coli MS 115-1 (11-581/582)
Q
TFRRL
------
W
PTIAPFKA
G
L
IVA
GVAL
-
IL
NA
A
SDTF
ML
S
L
LK
P
----LLD
DG
FGK---
T
DRS
VL
V
W
M
P
LV
V
I
GL
MI
----
L
RG
--
ITS
Y
VSS
Y
CI
S
W
V
SG-
-
--K
VV
MT
M
R
R
R
LFGHMM
GM
P
V
SFFD
K
Q
S
TG
T
L
L
SR
I
T
Y
D
S
E
-------
Q
V
A
SSSSGALI
TVVR
EG
A
SI
I
G
---
L
F
I
MMF
YY
SWQL
-
SI
I
L
I
V
L
A
P
I
VS
I
AI
------
R
VVSK
RFR
NIS
K
NMQ
N
T
MG
QVTT
S
AEQ
M
LK
G
HKE
V
LI
FG
GQEVETKRFDK
VSN
R
MRLQ-----------G
M
K
MV
S
A
S
S
-
IS
DP
I
I
Q
L
IA
SLAL
--
AF
V
L
Y
A
A
S
FPS
V
M
D
SLT
A
G
T
I
T
V
V
F
S
SMI
A
L
MR
PL
KS
LT
NV
-------
N
A
QF
QR
GM
AA
CQTL
F
T
I
L
D
S
E
Q
EK
------
DEGK
R
VIE
R
A
T
G
DVE
FR
NV
T
FTYP
GR
D
V
PAL
R
NINL
K
IP
A
G
KT
VALVG
R
S
GSGKST
I
ASLI
T
R
F
YD
I
D
EGEI
L
M
DG
H
D
L
RE
Y
T
L
A
SLR
NQ
VA
L
VSQ
N
V
H
LF
N
DTVANNIA
YAR
TEQY
S
R
E
Q
IE
E
AAR
M
A
YAM
D
F
I
NK
M
DN
G
L
DT
V
I
GE
N
GV
L
LSGGQ
R
QRIAIARALL
RDSP
ILILDEATSA
L
D
TE
S
E
R
AIQ
A
AL
DELQ
K
N
RT
S
LVIAHRLSTI
E
K
ADEIVV
V
ED
G
V
IVERGTH
ND
LL
EHR
G
V
Y
A
Q
LH
K
M
Q
FG
fig|679206.4.peg.3430
Escherichia coli MS 119-7 (11-581/582)
Q
TFRRL
------
W
PTIAPFKA
G
L
IVA
GVAL
-
IL
NA
A
SDTF
ML
S
L
LK
P
----LLD
DG
FGK---
T
DRS
VL
V
W
M
P
LV
V
I
GL
MI
----
L
RG
--
ITS
Y
VSS
Y
CI
S
W
V
SG-
-
--K
VV
MT
M
R
R
R
LFGHMM
GM
P
V
SFFD
K
Q
S
TG
T
L
L
SR
I
T
Y
D
S
E
-------
Q
V
A
SSSSGALI
TVVR
EG
A
SI
I
G
---
L
F
I
MMF
YY
SWQL
-
SI
I
L
I
V
L
A
P
I
VS
I
AI
------
R
VVSK
RFR
NIS
K
NMQ
N
T
MG
QVTT
S
AEQ
M
LK
G
HKE
V
LI
FG
GQEVETKRFDK
VSN
R
MRLQ-----------G
M
K
MV
S
A
S
S
-
IS
DP
I
I
Q
L
IA
SLAL
--
AF
V
L
Y
A
A
S
FPS
V
M
D
SLT
A
G
T
I
T
V
V
F
S
SMI
A
L
MR
PL
KS
LT
NV
-------
N
A
QF
QR
GM
AA
CQTL
F
T
I
L
D
S
E
Q
EK
------
DEGK
R
VIE
R
A
T
G
DVE
FR
NV
T
FTYP
GR
D
V
PAL
R
NINL
K
IP
A
G
KT
VALVG
R
S
GSGKST
I
ASLI
T
R
F
YD
I
D
EGEI
L
M
DG
H
D
L
RE
Y
T
L
A
SLR
NQ
VA
L
VSQ
N
V
H
LF
N
DTVANNIA
YAR
TEQY
S
R
E
Q
IE
E
AAR
M
A
YAM
D
F
I
NK
M
DN
G
L
DT
V
I
GE
N
GV
L
LSGGQ
R
QRIAIARALL
RDSP
ILILDEATSA
L
D
TE
S
E
R
AIQ
A
AL
DELQ
K
N
RT
S
LVIAHRLSTI
E
K
ADEIVV
V
ED
G
V
IVERGTH
ND
LL
EHR
G
V
Y
A
Q
LH
K
M
Q
FG
fig|679205.4.peg.1004
Escherichia coli MS 124-1 (11-581/582)
Q
TFRRL
------
W
PTIAPFKA
G
L
IVA
GVAL
-
IL
NA
A
SDTF
ML
S
L
LK
P
----LLD
DG
FGK---
T
DRS
VL
V
W
M
P
LV
V
I
GL
MI
----
L
RG
--
ITS
Y
VSS
Y
CI
S
W
V
SG-
-
--K
VV
MT
M
R
R
R
LFGHMM
GM
P
V
SFFD
K
Q
S
TG
T
L
L
SR
I
T
Y
D
S
E
-------
Q
V
A
SSSSGALI
TVVR
EG
A
SI
I
G
---
L
F
I
MMF
YY
SWQL
-
SI
I
L
I
V
L
A
P
I
VS
I
AI
------
R
VVSK
RFR
NIS
K
NMQ
N
T
MG
QVTT
S
AEQ
M
LK
G
HKE
V
LI
FG
GQEVETKRFDK
VSN
R
MRLQ-----------G
M
K
MV
S
A
S
S
-
IS
DP
I
I
Q
L
IA
SLAL
--
AF
V
L
Y
A
A
S
FPS
V
M
D
SLT
A
G
T
I
T
V
V
F
S
SMI
A
L
MR
PL
KS
LT
NV
-------
N
A
QF
QR
GM
AA
CQTL
F
T
I
L
D
S
E
Q
EK
------
DEGK
R
VIE
R
A
T
G
DVE
FR
NV
T
FTYP
GR
D
V
PAL
R
NINL
K
IP
A
G
KT
VALVG
R
S
GSGKST
I
ASLI
T
R
F
YD
I
D
EGEI
L
M
DG
H
D
L
RE
Y
T
L
A
SLR
NQ
VA
L
VSQ
N
V
H
LF
N
DTVANNIA
YAR
TEQY
S
R
E
Q
IE
E
AAR
M
A
YAM
D
F
I
NK
M
DN
G
L
DT
V
I
GE
N
GV
L
LSGGQ
R
QRIAIARALL
RDSP
ILILDEATSA
L
D
TE
S
E
R
AIQ
A
AL
DELQ
K
N
RT
S
LVIAHRLSTI
E
K
ADEIVV
V
ED
G
V
IVERGTH
ND
LL
EHR
G
V
Y
A
Q
LH
K
M
Q
FG
fig|679204.3.peg.2239
Escherichia coli MS 145-7 (11-581/582)
Q
TFRRL
------
W
PTIAPFKA
G
L
IVA
GVAL
-
IL
NA
A
SDTF
ML
S
L
LK
P
----LLD
DG
FGK---
T
DRS
VL
V
W
M
P
LV
V
I
GL
MI
----
L
RG
--
ITS
Y
VSS
Y
CI
S
W
V
SG-
-
--K
VV
MT
M
R
R
R
LFGHMM
GM
P
V
SFFD
K
Q
S
TG
T
L
L
SR
I
T
Y
D
S
E
-------
Q
V
A
SSSSGALI
TVVR
EG
A
SI
I
G
---
L
F
I
MMF
YY
SWQL
-
SI
I
L
I
V
L
A
P
I
VS
I
AI
------
R
VVSK
RFR
NIS
K
NMQ
N
T
MG
QVTT
S
AEQ
M
LK
G
HKE
V
LI
FG
GQEVETKRFDK
VSN
R
MRLQ-----------G
M
K
MV
S
A
S
S
-
IS
DP
I
I
Q
L
IA
SLAL
--
AF
V
L
Y
A
A
S
FPS
V
M
D
SLT
A
G
T
I
T
V
V
F
S
SMI
A
L
MR
PL
KS
LT
NV
-------
N
A
QF
QR
GM
AA
CQTL
F
T
I
L
D
S
E
Q
EK
------
DEGK
R
VIE
R
A
T
G
DVE
FR
NV
T
FTYP
GR
D
V
PAL
R
NINL
K
IP
A
G
KT
VALVG
R
S
GSGKST
I
ASLI
T
R
F
YD
I
D
EGEI
L
M
DG
H
D
L
RE
Y
T
L
A
SLR
NQ
VA
L
VSQ
N
V
H
LF
N
DTVANNIA
YAR
TEQY
S
R
E
Q
IE
E
AAR
M
A
YAM
D
F
I
NK
M
DN
G
L
DT
V
I
GE
N
GV
L
LSGGQ
R
QRIAIARALL
RDSP
ILILDEATSA
L
D
TE
S
E
R
AIQ
A
AL
DELQ
K
N
RT
S
LVIAHRLSTI
E
K
ADEIVV
V
ED
G
V
IVERGTH
ND
LL
EHR
G
V
Y
A
Q
LH
K
M
Q
FG
fig|749540.3.peg.104
Escherichia coli MS 146-1 (11-581/582)
Q
TFRRL
------
W
PTIAPFKA
G
L
IVA
GVAL
-
IL
NA
A
SDTF
ML
S
L
LK
P
----LLD
DG
FGK---
T
DRS
VL
V
W
M
P
LV
V
I
GL
MI
----
L
RG
--
ITS
Y
VSS
Y
CI
S
W
V
SG-
-
--K
VV
MT
M
R
R
R
LFGHMM
GM
P
V
SFFD
K
Q
S
TG
T
L
L
SR
I
T
Y
D
S
E
-------
Q
V
A
SSSSGALI
TVVR
EG
A
SI
I
G
---
L
F
I
MMF
YY
SWQL
-
SI
I
L
I
V
L
A
P
I
VS
I
AI
------
R
VVSK
RFR
NIS
K
NMQ
N
T
MG
QVTT
S
AEQ
M
LK
G
HKE
V
LI
FG
GQEVETKRFDK
VSN
R
MRLQ-----------G
M
K
MV
S
A
S
S
-
IS
DP
I
I
Q
L
IA
SLAL
--
AF
V
L
Y
A
A
S
FPS
V
M
D
SLT
A
G
T
I
T
V
V
F
S
SMI
A
L
MR
PL
KS
LT
NV
-------
N
A
QF
QR
GM
AA
CQTL
F
T
I
L
D
S
E
Q
EK
------
DEGK
R
VIE
R
A
T
G
DVE
FR
NV
T
FTYP
GR
D
V
PAL
R
NINL
K
IP
A
G
KT
VALVG
R
S
GSGKST
I
ASLI
T
R
F
YD
I
D
EGEI
L
M
DG
H
D
L
RE
Y
T
L
A
SLR
NQ
VA
L
VSQ
N
V
H
LF
N
DTVANNIA
YAR
TEQY
S
R
E
Q
IE
E
AAR
M
A
YAM
D
F
I
NK
M
DN
G
L
DT
V
I
GE
N
GV
L
LSGGQ
R
QRIAIARALL
RDSP
ILILDEATSA
L
D
TE
S
E
R
AIQ
A
AL
DELQ
K
N
RT
S
LVIAHRLSTI
E
K
ADEIVV
V
ED
G
V
IVERGTH
ND
LL
EHR
G
V
Y
A
Q
LH
K
M
Q
FG
fig|749544.3.peg.1260
Escherichia coli MS 175-1 (11-581/582)
Q
TFRRL
------
W
PTIAPFKA
G
L
IVA
GVAL
-
IL
NA
A
SDTF
ML
S
L
LK
P
----LLD
DG
FGK---
T
DRS
VL
V
W
M
P
LV
V
I
GL
MI
----
L
RG
--
ITS
Y
VSS
Y
CI
S
W
V
SG-
-
--K
VV
MT
M
R
R
R
LFGHMM
GM
P
V
SFFD
K
Q
S
TG
T
L
L
SR
I
T
Y
D
S
E
-------
Q
V
A
SSSSGALI
TVVR
EG
A
SI
I
G
---
L
F
I
MMF
YY
SWQL
-
SI
I
L
I
V
L
A
P
I
VS
I
AI
------
R
VVSK
RFR
NIS
K
NMQ
N
T
MG
QVTT
S
AEQ
M
LK
G
HKE
V
LI
FG
GQEVETKRFDK
VSN
R
MRLQ-----------G
M
K
MV
S
A
S
S
-
IS
DP
I
I
Q
L
IA
SLAL
--
AF
V
L
Y
A
A
S
FPS
V
M
D
SLT
A
G
T
I
T
V
V
F
S
SMI
A
L
MR
PL
KS
LT
NV
-------
N
A
QF
QR
GM
AA
CQTL
F
T
I
L
D
S
E
Q
EK
------
DEGK
R
VIE
R
A
T
G
DVE
FR
NV
T
FTYP
GR
D
V
PAL
R
NINL
K
IP
A
G
KT
VALVG
R
S
GSGKST
I
ASLI
T
R
F
YD
I
D
EGEI
L
M
DG
H
D
L
RE
Y
T
L
A
SLR
NQ
VA
L
VSQ
N
V
H
LF
N
DTVANNIA
YAR
TEQY
S
R
E
Q
IE
E
AAR
M
A
YAM
D
F
I
NK
M
DN
G
L
DT
V
I
GE
N
GV
L
LSGGQ
R
QRIAIARALL
RDSP
ILILDEATSA
L
D
TE
S
E
R
AIQ
A
AL
DELQ
K
N
RT
S
LVIAHRLSTI
E
K
ADEIVV
V
ED
G
V
IVERGTH
ND
LL
EHR
G
V
Y
A
Q
LH
K
M
Q
FG
fig|749545.3.peg.3241
Escherichia coli MS 182-1 (11-581/582)
Q
TFRRL
------
W
PTIAPFKA
G
L
IVA
GVAL
-
IL
NA
A
SDTF
ML
S
L
LK
P
----LLD
DG
FGK---
T
DRS
VL
V
W
M
P
LV
V
I
GL
MI
----
L
RG
--
ITS
Y
VSS
Y
CI
S
W
V
SG-
-
--K
VV
MT
M
R
R
R
LFGHMM
GM
P
V
SFFD
K
Q
S
TG
T
L
L
SR
I
T
Y
D
S
E
-------
Q
V
A
SSSSGALI
TVVR
EG
A
SI
I
G
---
L
F
I
MMF
YY
SWQL
-
SI
I
L
I
V
L
A
P
I
VS
I
AI
------
R
VVSK
RFR
NIS
K
NMQ
N
T
MG
QVTT
S
AEQ
M
LK
G
HKE
V
LI
FG
GQEVETKRFDK
VSN
R
MRLQ-----------G
M
K
MV
S
A
S
S
-
IS
DP
I
I
Q
L
IA
SLAL
--
AF
V
L
Y
A
A
S
FPS
V
M
D
SLT
A
G
T
I
T
V
V
F
S
SMI
A
L
MR
PL
KS
LT
NV
-------
N
A
QF
QR
GM
AA
CQTL
F
T
I
L
D
S
E
Q
EK
------
DEGK
R
VIE
R
A
T
G
DVE
FR
NV
T
FTYP
GR
D
V
PAL
R
NINL
K
IP
A
G
KT
VALVG
R
S
GSGKST
I
ASLI
T
R
F
YD
I
D
EGEI
L
M
DG
H
D
L
RE
Y
T
L
A
SLR
NQ
VA
L
VSQ
N
V
H
LF
N
DTVANNIA
YAR
TEQY
S
R
E
Q
IE
E
AAR
M
A
YAM
D
F
I
NK
M
DN
G
L
DT
V
I
GE
N
GV
L
LSGGQ
R
QRIAIARALL
RDSP
ILILDEATSA
L
D
TE
S
E
R
AIQ
A
AL
DELQ
K
N
RT
S
LVIAHRLSTI
E
K
ADEIVV
V
ED
G
V
IVERGTH
ND
LL
EHR
G
V
Y
A
Q
LH
K
M
Q
FG
fig|749547.3.peg.1865
Escherichia coli MS 187-1 (11-581/582)
Q
TFRRL
------
W
PTIAPFKA
G
L
IVA
GVAL
-
IL
NA
A
SDTF
ML
S
L
LK
P
----LLD
DG
FGK---
T
DRS
VL
V
W
M
P
LV
V
I
GL
MI
----
L
RG
--
ITS
Y
VSS
Y
CI
S
W
V
SG-
-
--K
VV
MT
M
R
R
R
LFGHMM
GM
P
V
SFFD
K
Q
S
TG
T
L
L
SR
I
T
Y
D
S
E
-------
Q
V
A
SSSSGALI
TVVR
EG
A
SI
I
G
---
L
F
I
MMF
YY
SWQL
-
SI
I
L
I
V
L
A
P
I
VS
I
AI
------
R
VVSK
RFR
NIS
K
NMQ
N
T
MG
QVTT
S
AEQ
M
LK
G
HKE
V
LI
FG
GQEVETKRFDK
VSN
R
MRLQ-----------G
M
K
MV
S
A
S
S
-
IS
DP
I
I
Q
L
IA
SLAL
--
AF
V
L
Y
A
A
S
FPS
V
M
D
SLT
A
G
T
I
T
V
V
F
S
SMI
A
L
MR
PL
KS
LT
NV
-------
N
A
QF
QR
GM
AA
CQTL
F
T
I
L
D
S
E
Q
EK
------
DEGK
R
VIE
R
A
T
G
DVE
FR
NV
T
FTYP
GR
D
V
PAL
R
NINL
K
IP
A
G
KT
VALVG
R
S
GSGKST
I
ASLI
T
R
F
YD
I
D
EGEI
L
M
DG
H
D
L
RE
Y
T
L
A
SLR
NQ
VA
L
VSQ
N
V
H
LF
N
DTVANNIA
YAR
TEQY
S
R
E
Q
IE
E
AAR
M
A
YAM
D
F
I
NK
M
DN
G
L
DT
V
I
GE
N
GV
L
LSGGQ
R
QRIAIARALL
RDSP
ILILDEATSA
L
D
TE
S
E
R
AIQ
A
AL
DELQ
K
N
RT
S
LVIAHRLSTI
E
K
ADEIVV
V
ED
G
V
IVERGTH
ND
LL
EHR
G
V
Y
A
Q
LH
K
M
Q
FG
fig|749548.3.peg.1418
Escherichia coli MS 196-1 (11-581/582)
Q
TFRRL
------
W
PTIAPFKA
G
L
IVA
GVAL
-
IL
NA
A
SDTF
ML
S
L
LK
P
----LLD
DG
FGK---
T
DRS
VL
V
W
M
P
LV
V
I
GL
MI
----
L
RG
--
ITS
Y
VSS
Y
CI
S
W
V
SG-
-
--K
VV
MT
M
R
R
R
LFGHMM
GM
P
V
SFFD
K
Q
S
TG
T
L
L
SR
I
T
Y
D
S
E
-------
Q
V
A
SSSSGALI
TVVR
EG
A
SI
I
G
---
L
F
I
MMF
YY
SWQL
-
SI
I
L
I
V
L
A
P
I
VS
I
AI
------
R
VVSK
RFR
NIS
K
NMQ
N
T
MG
QVTT
S
AEQ
M
LK
G
HKE
V
LI
FG
GQEVETKRFDK
VSN
R
MRLQ-----------G
M
K
MV
S
A
S
S
-
IS
DP
I
I
Q
L
IA
SLAL
--
AF
V
L
Y
A
A
S
FPS
V
M
D
SLT
A
G
T
I
T
V
V
F
S
SMI
A
L
MR
PL
KS
LT
NV
-------
N
A
QF
QR
GM
AA
CQTL
F
T
I
L
D
S
E
Q
EK
------
DEGK
R
VIE
R
A
T
G
DVE
FR
NV
T
FTYP
GR
D
V
PAL
R
NINL
K
IP
A
G
KT
VALVG
R
S
GSGKST
I
ASLI
T
R
F
YD
I
D
EGEI
L
M
DG
H
D
L
RE
Y
T
L
A
SLR
NQ
VA
L
VSQ
N
V
H
LF
N
DTVANNIA
YAR
TEQY
S
R
E
Q
IE
E
AAR
M
A
YAM
D
F
I
NK
M
DN
G
L
DT
V
I
GE
N
GV
L
LSGGQ
R
QRIAIARALL
RDSP
ILILDEATSA
L
D
TE
S
E
R
AIQ
A
AL
DELQ
K
N
RT
S
LVIAHRLSTI
E
K
ADEIVV
V
ED
G
V
IVERGTH
ND
LL
EHR
G
V
Y
A
Q
LH
K
M
Q
FG
fig|749533.3.peg.1000
Escherichia coli MS 84-1 (11-581/582)
Q
TFRRL
------
W
PTIAPFKA
G
L
IVA
GVAL
-
IL
NA
A
SDTF
ML
S
L
LK
P
----LLD
DG
FGK---
T
DRS
VL
V
W
M
P
LV
V
I
GL
MI
----
L
RG
--
ITS
Y
VSS
Y
CI
S
W
V
SG-
-
--K
VV
MT
M
R
R
R
LFGHMM
GM
P
V
SFFD
K
Q
S
TG
T
L
L
SR
I
T
Y
D
S
E
-------
Q
V
A
SSSSGALI
TVVR
EG
A
SI
I
G
---
L
F
I
MMF
YY
SWQL
-
SI
I
L
I
V
L
A
P
I
VS
I
AI
------
R
VVSK
RFR
NIS
K
NMQ
N
T
MG
QVTT
S
AEQ
M
LK
G
HKE
V
LI
FG
GQEVETKRFDK
VSN
R
MRLQ-----------G
M
K
MV
S
A
S
S
-
IS
DP
I
I
Q
L
IA
SLAL
--
AF
V
L
Y
A
A
S
FPS
V
M
D
SLT
A
G
T
I
T
V
V
F
S
SMI
A
L
MR
PL
KS
LT
NV
-------
N
A
QF
QR
GM
AA
CQTL
F
T
I
L
D
S
E
Q
EK
------
DEGK
R
VIE
R
A
T
G
DVE
FR
NV
T
FTYP
GR
D
V
PAL
R
NINL
K
IP
A
G
KT
VALVG
R
S
GSGKST
I
ASLI
T
R
F
YD
I
D
EGEI
L
M
DG
H
D
L
RE
Y
T
L
A
SLR
NQ
VA
L
VSQ
N
V
H
LF
N
DTVANNIA
YAR
TEQY
S
R
E
Q
IE
E
AAR
M
A
YAM
D
F
I
NK
M
DN
G
L
DT
V
I
GE
N
GV
L
LSGGQ
R
QRIAIARALL
RDSP
ILILDEATSA
L
D
TE
S
E
R
AIQ
A
AL
DELQ
K
N
RT
S
LVIAHRLSTI
E
K
ADEIVV
V
ED
G
V
IVERGTH
ND
LL
EHR
G
V
Y
A
Q
LH
K
M
Q
FG
fig|585396.4.peg.1023
Escherichia coli O111:H- str. 11128 (11-581/582)
Q
TFRRL
------
W
PTIAPFKA
G
L
IVA
GVAL
-
IL
NA
A
SDTF
ML
S
L
LK
P
----LLD
DG
FGK---
T
DRS
VL
V
W
M
P
LV
V
I
GL
MI
----
L
RG
--
ITS
Y
VSS
Y
CI
S
W
V
SG-
-
--K
VV
MT
M
R
R
R
LFGHMM
GM
P
V
SFFD
K
Q
S
TG
T
L
L
SR
I
T
Y
D
S
E
-------
Q
V
A
SSSSGALI
TVVR
EG
A
SI
I
G
---
L
F
I
MMF
YY
SWQL
-
SI
I
L
I
V
L
A
P
I
VS
I
AI
------
R
VVSK
RFR
NIS
K
NMQ
N
T
MG
QVTT
S
AEQ
M
LK
G
HKE
V
LI
FG
GQEVETKRFDK
VSN
R
MRLQ-----------G
M
K
MV
S
A
S
S
-
IS
DP
I
I
Q
L
IA
SLAL
--
AF
V
L
Y
A
A
S
FPS
V
M
D
SLT
A
G
T
I
T
V
V
F
S
SMI
A
L
MR
PL
KS
LT
NV
-------
N
A
QF
QR
GM
AA
CQTL
F
T
I
L
D
S
E
Q
EK
------
DEGK
R
VIE
R
A
T
G
DVE
FR
NV
T
FTYP
GR
D
V
PAL
R
NINL
K
IP
A
G
KT
VALVG
R
S
GSGKST
I
ASLI
T
R
F
YD
I
D
EGEI
L
M
DG
H
D
L
RE
Y
T
L
A
SLR
NQ
VA
L
VSQ
N
V
H
LF
N
DTVANNIA
YAR
TEQY
S
R
E
Q
IE
E
AAR
M
A
YAM
D
F
I
NK
M
DN
G
L
DT
V
I
GE
N
GV
L
LSGGQ
R
QRIAIARALL
RDSP
ILILDEATSA
L
D
TE
S
E
R
AIQ
A
AL
DELQ
K
N
RT
S
LVIAHRLSTI
E
K
ADEIVV
V
ED
G
V
IVERGTH
ND
LL
EHR
G
V
Y
A
Q
LH
K
M
Q
FG
fig|83334.1.peg.1065
Escherichia coli O157:H7 (11-581/582)
Q
TFRRL
------
W
PTIAPFKA
G
L
IVA
GVAL
-
IL
NA
A
SDTF
ML
S
L
LK
P
----LLD
DG
FGK---
T
DRS
VL
V
W
M
P
LV
V
I
GL
MI
----
L
RG
--
ITS
Y
VSS
Y
CI
S
W
V
SG-
-
--K
VV
MT
M
R
R
R
LFGHMM
GM
P
V
SFFD
K
Q
S
TG
T
L
L
SR
I
T
Y
D
S
E
-------
Q
V
A
SSSSGALI
TVVR
EG
A
SI
I
G
---
L
F
I
MMF
YY
SWQL
-
SI
I
L
I
V
L
A
P
I
VS
I
AI
------
R
VVSK
RFR
NIS
K
NMQ
N
T
MG
QVTT
S
AEQ
M
LK
G
HKE
V
LI
FG
GQEVETKRFDK
VSN
R
MRLQ-----------G
M
K
MV
S
A
S
S
-
IS
DP
I
I
Q
L
IA
SLAL
--
AF
V
L
Y
A
A
S
FPS
V
M
D
SLT
A
G
T
I
T
V
V
F
S
SMI
A
L
MR
PL
KS
LT
NV
-------
N
A
QF
QR
GM
AA
CQTL
F
T
I
L
D
S
E
Q
EK
------
DEGK
R
VIE
R
A
T
G
DVE
FR
NV
T
FTYP
GR
D
V
PAL
R
NINL
K
IP
A
G
KT
VALVG
R
S
GSGKST
I
ASLI
T
R
F
YD
I
D
EGEI
L
M
DG
H
D
L
RE
Y
T
L
A
SLR
NQ
VA
L
VSQ
N
V
H
LF
N
DTVANNIA
YAR
TEQY
S
R
E
Q
IE
E
AAR
M
A
YAM
D
F
I
NK
M
DN
G
L
DT
V
I
GE
N
GV
L
LSGGQ
R
QRIAIARALL
RDSP
ILILDEATSA
L
D
TE
S
E
R
AIQ
A
AL
DELQ
K
N
RT
S
LVIAHRLSTI
E
K
ADEIVV
V
ED
G
V
IVERGTH
ND
LL
EHR
G
V
Y
A
Q
LH
K
M
Q
FG
fig|155864.1.peg.1097
Escherichia coli O157:H7 EDL933 (11-581/582)
Q
TFRRL
------
W
PTIAPFKA
G
L
IVA
GVAL
-
IL
NA
A
SDTF
ML
S
L
LK
P
----LLD
DG
FGK---
T
DRS
VL
V
W
M
P
LV
V
I
GL
MI
----
L
RG
--
ITS
Y
VSS
Y
CI
S
W
V
SG-
-
--K
VV
MT
M
R
R
R
LFGHMM
GM
P
V
SFFD
K
Q
S
TG
T
L
L
SR
I
T
Y
D
S
E
-------
Q
V
A
SSSSGALI
TVVR
EG
A
SI
I
G
---
L
F
I
MMF
YY
SWQL
-
SI
I
L
I
V
L
A
P
I
VS
I
AI
------
R
VVSK
RFR
NIS
K
NMQ
N
T
MG
QVTT
S
AEQ
M
LK
G
HKE
V
LI
FG
GQEVETKRFDK
VSN
R
MRLQ-----------G
M
K
MV
S
A
S
S
-
IS
DP
I
I
Q
L
IA
SLAL
--
AF
V
L
Y
A
A
S
FPS
V
M
D
SLT
A
G
T
I
T
V
V
F
S
SMI
A
L
MR
PL
KS
LT
NV
-------
N
A
QF
QR
GM
AA
CQTL
F
T
I
L
D
S
E
Q
EK
------
DEGK
R
VIE
R
A
T
G
DVE
FR
NV
T
FTYP
GR
D
V
PAL
R
NINL
K
IP
A
G
KT
VALVG
R
S
GSGKST
I
ASLI
T
R
F
YD
I
D
EGEI
L
M
DG
H
D
L
RE
Y
T
L
A
SLR
NQ
VA
L
VSQ
N
V
H
LF
N
DTVANNIA
YAR
TEQY
S
R
E
Q
IE
E
AAR
M
A
YAM
D
F
I
NK
M
DN
G
L
DT
V
I
GE
N
GV
L
LSGGQ
R
QRIAIARALL
RDSP
ILILDEATSA
L
D
TE
S
E
R
AIQ
A
AL
DELQ
K
N
RT
S
LVIAHRLSTI
E
K
ADEIVV
V
ED
G
V
IVERGTH
ND
LL
EHR
G
V
Y
A
Q
LH
K
M
Q
FG
fig|155864.8.peg.1130
Escherichia coli O157:H7 EDL933 (11-581/582)
Q
TFRRL
------
W
PTIAPFKA
G
L
IVA
GVAL
-
IL
NA
A
SDTF
ML
S
L
LK
P
----LLD
DG
FGK---
T
DRS
VL
V
W
M
P
LV
V
I
GL
MI
----
L
RG
--
ITS
Y
VSS
Y
CI
S
W
V
SG-
-
--K
VV
MT
M
R
R
R
LFGHMM
GM
P
V
SFFD
K
Q
S
TG
T
L
L
SR
I
T
Y
D
S
E
-------
Q
V
A
SSSSGALI
TVVR
EG
A
SI
I
G
---
L
F
I
MMF
YY
SWQL
-
SI
I
L
I
V
L
A
P
I
VS
I
AI
------
R
VVSK
RFR
NIS
K
NMQ
N
T
MG
QVTT
S
AEQ
M
LK
G
HKE
V
LI
FG
GQEVETKRFDK
VSN
R
MRLQ-----------G
M
K
MV
S
A
S
S
-
IS
DP
I
I
Q
L
IA
SLAL
--
AF
V
L
Y
A
A
S
FPS
V
M
D
SLT
A
G
T
I
T
V
V
F
S
SMI
A
L
MR
PL
KS
LT
NV
-------
N
A
QF
QR
GM
AA
CQTL
F
T
I
L
D
S
E
Q
EK
------
DEGK
R
VIE
R
A
T
G
DVE
FR
NV
T
FTYP
GR
D
V
PAL
R
NINL
K
IP
A
G
KT
VALVG
R
S
GSGKST
I
ASLI
T
R
F
YD
I
D
EGEI
L
M
DG
H
D
L
RE
Y
T
L
A
SLR
NQ
VA
L
VSQ
N
V
H
LF
N
DTVANNIA
YAR
TEQY
S
R
E
Q
IE
E
AAR
M
A
YAM
D
F
I
NK
M
DN
G
L
DT
V
I
GE
N
GV
L
LSGGQ
R
QRIAIARALL
RDSP
ILILDEATSA
L
D
TE
S
E
R
AIQ
A
AL
DELQ
K
N
RT
S
LVIAHRLSTI
E
K
ADEIVV
V
ED
G
V
IVERGTH
ND
LL
EHR
G
V
Y
A
Q
LH
K
M
Q
FG
fig|444454.5.peg.5495
Escherichia coli O157:H7 str. EC4024 (11-581/582)
Q
TFRRL
------
W
PTIAPFKA
G
L
IVA
GVAL
-
IL
NA
A
SDTF
ML
S
L
LK
P
----LLD
DG
FGK---
T
DRS
VL
V
W
M
P
LV
V
I
GL
MI
----
L
RG
--
ITS
Y
VSS
Y
CI
S
W
V
SG-
-
--K
VV
MT
M
R
R
R
LFGHMM
GM
P
V
SFFD
K
Q
S
TG
T
L
L
SR
I
T
Y
D
S
E
-------
Q
V
A
SSSSGALI
TVVR
EG
A
SI
I
G
---
L
F
I
MMF
YY
SWQL
-
SI
I
L
I
V
L
A
P
I
VS
I
AI
------
R
VVSK
RFR
NIS
K
NMQ
N
T
MG
QVTT
S
AEQ
M
LK
G
HKE
V
LI
FG
GQEVETKRFDK
VSN
R
MRLQ-----------G
M
K
MV
S
A
S
S
-
IS
DP
I
I
Q
L
IA
SLAL
--
AF
V
L
Y
A
A
S
FPS
V
M
D
SLT
A
G
T
I
T
V
V
F
S
SMI
A
L
MR
PL
KS
LT
NV
-------
N
A
QF
QR
GM
AA
CQTL
F
T
I
L
D
S
E
Q
EK
------
DEGK
R
VIE
R
A
T
G
DVE
FR
NV
T
FTYP
GR
D
V
PAL
R
NINL
K
IP
A
G
KT
VALVG
R
S
GSGKST
I
ASLI
T
R
F
YD
I
D
EGEI
L
M
DG
H
D
L
RE
Y
T
L
A
SLR
NQ
VA
L
VSQ
N
V
H
LF
N
DTVANNIA
YAR
TEQY
S
R
E
Q
IE
E
AAR
M
A
YAM
D
F
I
NK
M
DN
G
L
DT
V
I
GE
N
GV
L
LSGGQ
R
QRIAIARALL
RDSP
ILILDEATSA
L
D
TE
S
E
R
AIQ
A
AL
DELQ
K
N
RT
S
LVIAHRLSTI
E
K
ADEIVV
V
ED
G
V
IVERGTH
ND
LL
EHR
G
V
Y
A
Q
LH
K
M
Q
FG
fig|444449.5.peg.4429
Escherichia coli O157:H7 str. EC4042 (11-581/582)
Q
TFRRL
------
W
PTIAPFKA
G
L
IVA
GVAL
-
IL
NA
A
SDTF
ML
S
L
LK
P
----LLD
DG
FGK---
T
DRS
VL
V
W
M
P
LV
V
I
GL
MI
----
L
RG
--
ITS
Y
VSS
Y
CI
S
W
V
SG-
-
--K
VV
MT
M
R
R
R
LFGHMM
GM
P
V
SFFD
K
Q
S
TG
T
L
L
SR
I
T
Y
D
S
E
-------
Q
V
A
SSSSGALI
TVVR
EG
A
SI
I
G
---
L
F
I
MMF
YY
SWQL
-
SI
I
L
I
V
L
A
P
I
VS
I
AI
------
R
VVSK
RFR
NIS
K
NMQ
N
T
MG
QVTT
S
AEQ
M
LK
G
HKE
V
LI
FG
GQEVETKRFDK
VSN
R
MRLQ-----------G
M
K
MV
S
A
S
S
-
IS
DP
I
I
Q
L
IA
SLAL
--
AF
V
L
Y
A
A
S
FPS
V
M
D
SLT
A
G
T
I
T
V
V
F
S
SMI
A
L
MR
PL
KS
LT
NV
-------
N
A
QF
QR
GM
AA
CQTL
F
T
I
L
D
S
E
Q
EK
------
DEGK
R
VIE
R
A
T
G
DVE
FR
NV
T
FTYP
GR
D
V
PAL
R
NINL
K
IP
A
G
KT
VALVG
R
S
GSGKST
I
ASLI
T
R
F
YD
I
D
EGEI
L
M
DG
H
D
L
RE
Y
T
L
A
SLR
NQ
VA
L
VSQ
N
V
H
LF
N
DTVANNIA
YAR
TEQY
S
R
E
Q
IE
E
AAR
M
A
YAM
D
F
I
NK
M
DN
G
L
DT
V
I
GE
N
GV
L
LSGGQ
R
QRIAIARALL
RDSP
ILILDEATSA
L
D
TE
S
E
R
AIQ
A
AL
DELQ
K
N
RT
S
LVIAHRLSTI
E
K
ADEIVV
V
ED
G
V
IVERGTH
ND
LL
EHR
G
V
Y
A
Q
LH
K
M
Q
FG
fig|444448.5.peg.3705
Escherichia coli O157:H7 str. EC4045 (11-581/582)
Q
TFRRL
------
W
PTIAPFKA
G
L
IVA
GVAL
-
IL
NA
A
SDTF
ML
S
L
LK
P
----LLD
DG
FGK---
T
DRS
VL
V
W
M
P
LV
V
I
GL
MI
----
L
RG
--
ITS
Y
VSS
Y
CI
S
W
V
SG-
-
--K
VV
MT
M
R
R
R
LFGHMM
GM
P
V
SFFD
K
Q
S
TG
T
L
L
SR
I
T
Y
D
S
E
-------
Q
V
A
SSSSGALI
TVVR
EG
A
SI
I
G
---
L
F
I
MMF
YY
SWQL
-
SI
I
L
I
V
L
A
P
I
VS
I
AI
------
R
VVSK
RFR
NIS
K
NMQ
N
T
MG
QVTT
S
AEQ
M
LK
G
HKE
V
LI
FG
GQEVETKRFDK
VSN
R
MRLQ-----------G
M
K
MV
S
A
S
S
-
IS
DP
I
I
Q
L
IA
SLAL
--
AF
V
L
Y
A
A
S
FPS
V
M
D
SLT
A
G
T
I
T
V
V
F
S
SMI
A
L
MR
PL
KS
LT
NV
-------
N
A
QF
QR
GM
AA
CQTL
F
T
I
L
D
S
E
Q
EK
------
DEGK
R
VIE
R
A
T
G
DVE
FR
NV
T
FTYP
GR
D
V
PAL
R
NINL
K
IP
A
G
KT
VALVG
R
S
GSGKST
I
ASLI
T
R
F
YD
I
D
EGEI
L
M
DG
H
D
L
RE
Y
T
L
A
SLR
NQ
VA
L
VSQ
N
V
H
LF
N
DTVANNIA
YAR
TEQY
S
R
E
Q
IE
E
AAR
M
A
YAM
D
F
I
NK
M
DN
G
L
DT
V
I
GE
N
GV
L
LSGGQ
R
QRIAIARALL
RDSP
ILILDEATSA
L
D
TE
S
E
R
AIQ
A
AL
DELQ
K
N
RT
S
LVIAHRLSTI
E
K
ADEIVV
V
ED
G
V
IVERGTH
ND
LL
EHR
G
V
Y
A
Q
LH
K
M
Q
FG
fig|444453.5.peg.5358
Escherichia coli O157:H7 str. EC4076 (11-581/582)
Q
TFRRL
------
W
PTIAPFKA
G
L
IVA
GVAL
-
IL
NA
A
SDTF
ML
S
L
LK
P
----LLD
DG
FGK---
T
DRS
VL
V
W
M
P
LV
V
I
GL
MI
----
L
RG
--
ITS
Y
VSS
Y
CI
S
W
V
SG-
-
--K
VV
MT
M
R
R
R
LFGHMM
GM
P
V
SFFD
K
Q
S
TG
T
L
L
SR
I
T
Y
D
S
E
-------
Q
V
A
SSSSGALI
TVVR
EG
A
SI
I
G
---
L
F
I
MMF
YY
SWQL
-
SI
I
L
I
V
L
A
P
I
VS
I
AI
------
R
VVSK
RFR
NIS
K
NMQ
N
T
MG
QVTT
S
AEQ
M
LK
G
HKE
V
LI
FG
GQEVETKRFDK
VSN
R
MRLQ-----------G
M
K
MV
S
A
S
S
-
IS
DP
I
I
Q
L
IA
SLAL
--
AF
V
L
Y
A
A
S
FPS
V
M
D
SLT
A
G
T
I
T
V
V
F
S
SMI
A
L
MR
PL
KS
LT
NV
-------
N
A
QF
QR
GM
AA
CQTL
F
T
I
L
D
S
E
Q
EK
------
DEGK
R
VIE
R
A
T
G
DVE
FR
NV
T
FTYP
GR
D
V
PAL
R
NINL
K
IP
A
G
KT
VALVG
R
S
GSGKST
I
ASLI
T
R
F
YD
I
D
EGEI
L
M
DG
H
D
L
RE
Y
T
L
A
SLR
NQ
VA
L
VSQ
N
V
H
LF
N
DTVANNIA
YAR
TEQY
S
R
E
Q
IE
E
AAR
M
A
YAM
D
F
I
NK
M
DN
G
L
DT
V
I
GE
N
GV
L
LSGGQ
R
QRIAIARALL
RDSP
ILILDEATSA
L
D
TE
S
E
R
AIQ
A
AL
DELQ
K
N
RT
S
LVIAHRLSTI
E
K
ADEIVV
V
ED
G
V
IVERGTH
ND
LL
EHR
G
V
Y
A
Q
LH
K
M
Q
FG
fig|444452.5.peg.4074
Escherichia coli O157:H7 str. EC4113 (11-581/582)
Q
TFRRL
------
W
PTIAPFKA
G
L
IVA
GVAL
-
IL
NA
A
SDTF
ML
S
L
LK
P
----LLD
DG
FGK---
T
DRS
VL
V
W
M
P
LV
V
I
GL
MI
----
L
RG
--
ITS
Y
VSS
Y
CI
S
W
V
SG-
-
--K
VV
MT
M
R
R
R
LFGHMM
GM
P
V
SFFD
K
Q
S
TG
T
L
L
SR
I
T
Y
D
S
E
-------
Q
V
A
SSSSGALI
TVVR
EG
A
SI
I
G
---
L
F
I
MMF
YY
SWQL
-
SI
I
L
I
V
L
A
P
I
VS
I
AI
------
R
VVSK
RFR
NIS
K
NMQ
N
T
MG
QVTT
S
AEQ
M
LK
G
HKE
V
LI
FG
GQEVETKRFDK
VSN
R
MRLQ-----------G
M
K
MV
S
A
S
S
-
IS
DP
I
I
Q
L
IA
SLAL
--
AF
V
L
Y
A
A
S
FPS
V
M
D
SLT
A
G
T
I
T
V
V
F
S
SMI
A
L
MR
PL
KS
LT
NV
-------
N
A
QF
QR
GM
AA
CQTL
F
T
I
L
D
S
E
Q
EK
------
DEGK
R
VIE
R
A
T
G
DVE
FR
NV
T
FTYP
GR
D
V
PAL
R
NINL
K
IP
A
G
KT
VALVG
R
S
GSGKST
I
ASLI
T
R
F
YD
I
D
EGEI
L
M
DG
H
D
L
RE
Y
T
L
A
SLR
NQ
VA
L
VSQ
N
V
H
LF
N
DTVANNIA
YAR
TEQY
S
R
E
Q
IE
E
AAR
M
A
YAM
D
F
I
NK
M
DN
G
L
DT
V
I
GE
N
GV
L
LSGGQ
R
QRIAIARALL
RDSP
ILILDEATSA
L
D
TE
S
E
R
AIQ
A
AL
DELQ
K
N
RT
S
LVIAHRLSTI
E
K
ADEIVV
V
ED
G
V
IVERGTH
ND
LL
EHR
G
V
Y
A
Q
LH
K
M
Q
FG
fig|444450.8.peg.1162
Escherichia coli O157:H7 str. EC4115 (11-581/582)
Q
TFRRL
------
W
PTIAPFKA
G
L
IVA
GVAL
-
IL
NA
A
SDTF
ML
S
L
LK
P
----LLD
DG
FGK---
T
DRS
VL
V
W
M
P
LV
V
I
GL
MI
----
L
RG
--
ITS
Y
VSS
Y
CI
S
W
V
SG-
-
--K
VV
MT
M
R
R
R
LFGHMM
GM
P
V
SFFD
K
Q
S
TG
T
L
L
SR
I
T
Y
D
S
E
-------
Q
V
A
SSSSGALI
TVVR
EG
A
SI
I
G
---
L
F
I
MMF
YY
SWQL
-
SI
I
L
I
V
L
A
P
I
VS
I
AI
------
R
VVSK
RFR
NIS
K
NMQ
N
T
MG
QVTT
S
AEQ
M
LK
G
HKE
V
LI
FG
GQEVETKRFDK
VSN
R
MRLQ-----------G
M
K
MV
S
A
S
S
-
IS
DP
I
I
Q
L
IA
SLAL
--
AF
V
L
Y
A
A
S
FPS
V
M
D
SLT
A
G
T
I
T
V
V
F
S
SMI
A
L
MR
PL
KS
LT
NV
-------
N
A
QF
QR
GM
AA
CQTL
F
T
I
L
D
S
E
Q
EK
------
DEGK
R
VIE
R
A
T
G
DVE
FR
NV
T
FTYP
GR
D
V
PAL
R
NINL
K
IP
A
G
KT
VALVG
R
S
GSGKST
I
ASLI
T
R
F
YD
I
D
EGEI
L
M
DG
H
D
L
RE
Y
T
L
A
SLR
NQ
VA
L
VSQ
N
V
H
LF
N
DTVANNIA
YAR
TEQY
S
R
E
Q
IE
E
AAR
M
A
YAM
D
F
I
NK
M
DN
G
L
DT
V
I
GE
N
GV
L
LSGGQ
R
QRIAIARALL
RDSP
ILILDEATSA
L
D
TE
S
E
R
AIQ
A
AL
DELQ
K
N
RT
S
LVIAHRLSTI
E
K
ADEIVV
V
ED
G
V
IVERGTH
ND
LL
EHR
G
V
Y
A
Q
LH
K
M
Q
FG
fig|444451.5.peg.3752
Escherichia coli O157:H7 str. EC4196 (11-581/582)
Q
TFRRL
------
W
PTIAPFKA
G
L
IVA
GVAL
-
IL
NA
A
SDTF
ML
S
L
LK
P
----LLD
DG
FGK---
T
DRS
VL
V
W
M
P
LV
V
I
GL
MI
----
L
RG
--
ITS
Y
VSS
Y
CI
S
W
V
SG-
-
--K
VV
MT
M
R
R
R
LFGHMM
GM
P
V
SFFD
K
Q
S
TG
T
L
L
SR
I
T
Y
D
S
E
-------
Q
V
A
SSSSGALI
TVVR
EG
A
SI
I
G
---
L
F
I
MMF
YY
SWQL
-
SI
I
L
I
V
L
A
P
I
VS
I
AI
------
R
VVSK
RFR
NIS
K
NMQ
N
T
MG
QVTT
S
AEQ
M
LK
G
HKE
V
LI
FG
GQEVETKRFDK
VSN
R
MRLQ-----------G
M
K
MV
S
A
S
S
-
IS
DP
I
I
Q
L
IA
SLAL
--
AF
V
L
Y
A
A
S
FPS
V
M
D
SLT
A
G
T
I
T
V
V
F
S
SMI
A
L
MR
PL
KS
LT
NV
-------
N
A
QF
QR
GM
AA
CQTL
F
T
I
L
D
S
E
Q
EK
------
DEGK
R
VIE
R
A
T
G
DVE
FR
NV
T
FTYP
GR
D
V
PAL
R
NINL
K
IP
A
G
KT
VALVG
R
S
GSGKST
I
ASLI
T
R
F
YD
I
D
EGEI
L
M
DG
H
D
L
RE
Y
T
L
A
SLR
NQ
VA
L
VSQ
N
V
H
LF
N
DTVANNIA
YAR
TEQY
S
R
E
Q
IE
E
AAR
M
A
YAM
D
F
I
NK
M
DN
G
L
DT
V
I
GE
N
GV
L
LSGGQ
R
QRIAIARALL
RDSP
ILILDEATSA
L
D
TE
S
E
R
AIQ
A
AL
DELQ
K
N
RT
S
LVIAHRLSTI
E
K
ADEIVV
V
ED
G
V
IVERGTH
ND
LL
EHR
G
V
Y
A
Q
LH
K
M
Q
FG
fig|444447.5.peg.3916
Escherichia coli O157:H7 str. EC4206 (11-581/582)
Q
TFRRL
------
W
PTIAPFKA
G
L
IVA
GVAL
-
IL
NA
A
SDTF
ML
S
L
LK
P
----LLD
DG
FGK---
T
DRS
VL
V
W
M
P
LV
V
I
GL
MI
----
L
RG
--
ITS
Y
VSS
Y
CI
S
W
V
SG-
-
--K
VV
MT
M
R
R
R
LFGHMM
GM
P
V
SFFD
K
Q
S
TG
T
L
L
SR
I
T
Y
D
S
E
-------
Q
V
A
SSSSGALI
TVVR
EG
A
SI
I
G
---
L
F
I
MMF
YY
SWQL
-
SI
I
L
I
V
L
A
P
I
VS
I
AI
------
R
VVSK
RFR
NIS
K
NMQ
N
T
MG
QVTT
S
AEQ
M
LK
G
HKE
V
LI
FG
GQEVETKRFDK
VSN
R
MRLQ-----------G
M
K
MV
S
A
S
S
-
IS
DP
I
I
Q
L
IA
SLAL
--
AF
V
L
Y
A
A
S
FPS
V
M
D
SLT
A
G
T
I
T
V
V
F
S
SMI
A
L
MR
PL
KS
LT
NV
-------
N
A
QF
QR
GM
AA
CQTL
F
T
I
L
D
S
E
Q
EK
------
DEGK
R
VIE
R
A
T
G
DVE
FR
NV
T
FTYP
GR
D
V
PAL
R
NINL
K
IP
A
G
KT
VALVG
R
S
GSGKST
I
ASLI
T
R
F
YD
I
D
EGEI
L
M
DG
H
D
L
RE
Y
T
L
A
SLR
NQ
VA
L
VSQ
N
V
H
LF
N
DTVANNIA
YAR
TEQY
S
R
E
Q
IE
E
AAR
M
A
YAM
D
F
I
NK
M
DN
G
L
DT
V
I
GE
N
GV
L
LSGGQ
R
QRIAIARALL
RDSP
ILILDEATSA
L
D
TE
S
E
R
AIQ
A
AL
DELQ
K
N
RT
S
LVIAHRLSTI
E
K
ADEIVV
V
ED
G
V
IVERGTH
ND
LL
EHR
G
V
Y
A
Q
LH
K
M
Q
FG
fig|478004.5.peg.3699
Escherichia coli O157:H7 str. EC4401 (11-581/582)
Q
TFRRL
------
W
PTIAPFKA
G
L
IVA
GVAL
-
IL
NA
A
SDTF
ML
S
L
LK
P
----LLD
DG
FGK---
T
DRS
VL
V
W
M
P
LV
V
I
GL
MI
----
L
RG
--
ITS
Y
VSS
Y
CI
S
W
V
SG-
-
--K
VV
MT
M
R
R
R
LFGHMM
GM
P
V
SFFD
K
Q
S
TG
T
L
L
SR
I
T
Y
D
S
E
-------
Q
V
A
SSSSGALI
TVVR
EG
A
SI
I
G
---
L
F
I
MMF
YY
SWQL
-
SI
I
L
I
V
L
A
P
I
VS
I
AI
------
R
VVSK
RFR
NIS
K
NMQ
N
T
MG
QVTT
S
AEQ
M
LK
G
HKE
V
LI
FG
GQEVETKRFDK
VSN
R
MRLQ-----------G
M
K
MV
S
A
S
S
-
IS
DP
I
I
Q
L
IA
SLAL
--
AF
V
L
Y
A
A
S
FPS
V
M
D
SLT
A
G
T
I
T
V
V
F
S
SMI
A
L
MR
PL
KS
LT
NV
-------
N
A
QF
QR
GM
AA
CQTL
F
T
I
L
D
S
E
Q
EK
------
DEGK
R
VIE
R
A
T
G
DVE
FR
NV
T
FTYP
GR
D
V
PAL
R
NINL
K
IP
A
G
KT
VALVG
R
S
GSGKST
I
ASLI
T
R
F
YD
I
D
EGEI
L
M
DG
H
D
L
RE
Y
T
L
A
SLR
NQ
VA
L
VSQ
N
V
H
LF
N
DTVANNIA
YAR
TEQY
S
R
E
Q
IE
E
AAR
M
A
YAM
D
F
I
NK
M
DN
G
L
DT
V
I
GE
N
GV
L
LSGGQ
R
QRIAIARALL
RDSP
ILILDEATSA
L
D
TE
S
E
R
AIQ
A
AL
DELQ
K
N
RT
S
LVIAHRLSTI
E
K
ADEIVV
V
ED
G
V
IVERGTH
ND
LL
EHR
G
V
Y
A
Q
LH
K
M
Q
FG
fig|478005.5.peg.3751
Escherichia coli O157:H7 str. EC4486 (11-581/582)
Q
TFRRL
------
W
PTIAPFKA
G
L
IVA
GVAL
-
IL
NA
A
SDTF
ML
S
L
LK
P
----LLD
DG
FGK---
T
DRS
VL
V
W
M
P
LV
V
I
GL
MI
----
L
RG
--
ITS
Y
VSS
Y
CI
S
W
V
SG-
-
--K
VV
MT
M
R
R
R
LFGHMM
GM
P
V
SFFD
K
Q
S
TG
T
L
L
SR
I
T
Y
D
S
E
-------
Q
V
A
SSSSGALI
TVVR
EG
A
SI
I
G
---
L
F
I
MMF
YY
SWQL
-
SI
I
L
I
V
L
A
P
I
VS
I
AI
------
R
VVSK
RFR
NIS
K
NMQ
N
T
MG
QVTT
S
AEQ
M
LK
G
HKE
V
LI
FG
GQEVETKRFDK
VSN
R
MRLQ-----------G
M
K
MV
S
A
S
S
-
IS
DP
I
I
Q
L
IA
SLAL
--
AF
V
L
Y
A
A
S
FPS
V
M
D
SLT
A
G
T
I
T
V
V
F
S
SMI
A
L
MR
PL
KS
LT
NV
-------
N
A
QF
QR
GM
AA
CQTL
F
T
I
L
D
S
E
Q
EK
------
DEGK
R
VIE
R
A
T
G
DVE
FR
NV
T
FTYP
GR
D
V
PAL
R
NINL
K
IP
A
G
KT
VALVG
R
S
GSGKST
I
ASLI
T
R
F
YD
I
D
EGEI
L
M
DG
H
D
L
RE
Y
T
L
A
SLR
NQ
VA
L
VSQ
N
V
H
LF
N
DTVANNIA
YAR
TEQY
S
R
E
Q
IE
E
AAR
M
A
YAM
D
F
I
NK
M
DN
G
L
DT
V
I
GE
N
GV
L
LSGGQ
R
QRIAIARALL
RDSP
ILILDEATSA
L
D
TE
S
E
R
AIQ
A
AL
DELQ
K
N
RT
S
LVIAHRLSTI
E
K
ADEIVV
V
ED
G
V
IVERGTH
ND
LL
EHR
G
V
Y
A
Q
LH
K
M
Q
FG
fig|478006.5.peg.3387
Escherichia coli O157:H7 str. EC4501 (11-581/582)
Q
TFRRL
------
W
PTIAPFKA
G
L
IVA
GVAL
-
IL
NA
A
SDTF
ML
S
L
LK
P
----LLD
DG
FGK---
T
DRS
VL
V
W
M
P
LV
V
I
GL
MI
----
L
RG
--
ITS
Y
VSS
Y
CI
S
W
V
SG-
-
--K
VV
MT
M
R
R
R
LFGHMM
GM
P
V
SFFD
K
Q
S
TG
T
L
L
SR
I
T
Y
D
S
E
-------
Q
V
A
SSSSGALI
TVVR
EG
A
SI
I
G
---
L
F
I
MMF
YY
SWQL
-
SI
I
L
I
V
L
A
P
I
VS
I
AI
------
R
VVSK
RFR
NIS
K
NMQ
N
T
MG
QVTT
S
AEQ
M
LK
G
HKE
V
LI
FG
GQEVETKRFDK
VSN
R
MRLQ-----------G
M
K
MV
S
A
S
S
-
IS
DP
I
I
Q
L
IA
SLAL
--
AF
V
L
Y
A
A
S
FPS
V
M
D
SLT
A
G
T
I
T
V
V
F
S
SMI
A
L
MR
PL
KS
LT
NV
-------
N
A
QF
QR
GM
AA
CQTL
F
T
I
L
D
S
E
Q
EK
------
DEGK
R
VIE
R
A
T
G
DVE
FR
NV
T
FTYP
GR
D
V
PAL
R
NINL
K
IP
A
G
KT
VALVG
R
S
GSGKST
I
ASLI
T
R
F
YD
I
D
EGEI
L
M
DG
H
D
L
RE
Y
T
L
A
SLR
NQ
VA
L
VSQ
N
V
H
LF
N
DTVANNIA
YAR
TEQY
S
R
E
Q
IE
E
AAR
M
A
YAM
D
F
I
NK
M
DN
G
L
DT
V
I
GE
N
GV
L
LSGGQ
R
QRIAIARALL
RDSP
ILILDEATSA
L
D
TE
S
E
R
AIQ
A
AL
DELQ
K
N
RT
S
LVIAHRLSTI
E
K
ADEIVV
V
ED
G
V
IVERGTH
ND
LL
EHR
G
V
Y
A
Q
LH
K
M
Q
FG
fig|478007.5.peg.4015
Escherichia coli O157:H7 str. EC508 (11-581/582)
Q
TFRRL
------
W
PTIAPFKA
G
L
IVA
GVAL
-
IL
NA
A
SDTF
ML
S
L
LK
P
----LLD
DG
FGK---
T
DRS
VL
V
W
M
P
LV
V
I
GL
MI
----
L
RG
--
ITS
Y
VSS
Y
CI
S
W
V
SG-
-
--K
VV
MT
M
R
R
R
LFGHMM
GM
P
V
SFFD
K
Q
S
TG
T
L
L
SR
I
T
Y
D
S
E
-------
Q
V
A
SSSSGALI
TVVR
EG
A
SI
I
G
---
L
F
I
MMF
YY
SWQL
-
SI
I
L
I
V
L
A
P
I
VS
I
AI
------
R
VVSK
RFR
NIS
K
NMQ
N
T
MG
QVTT
S
AEQ
M
LK
G
HKE
V
LI
FG
GQEVETKRFDK
VSN
R
MRLQ-----------G
M
K
MV
S
A
S
S
-
IS
DP
I
I
Q
L
IA
SLAL
--
AF
V
L
Y
A
A
S
FPS
V
M
D
SLT
A
G
T
I
T
V
V
F
S
SMI
A
L
MR
PL
KS
LT
NV
-------
N
A
QF
QR
GM
AA
CQTL
F
T
I
L
D
S
E
Q
EK
------
DEGK
R
VIE
R
A
T
G
DVE
FR
NV
T
FTYP
GR
D
V
PAL
R
NINL
K
IP
A
G
KT
VALVG
R
S
GSGKST
I
ASLI
T
R
F
YD
I
D
EGEI
L
M
DG
H
D
L
RE
Y
T
L
A
SLR
NQ
VA
L
VSQ
N
V
H
LF
N
DTVANNIA
YAR
TEQY
S
R
E
Q
IE
E
AAR
M
A
YAM
D
F
I
NK
M
DN
G
L
DT
V
I
GE
N
GV
L
LSGGQ
R
QRIAIARALL
RDSP
ILILDEATSA
L
D
TE
S
E
R
AIQ
A
AL
DELQ
K
N
RT
S
LVIAHRLSTI
E
K
ADEIVV
V
ED
G
V
IVERGTH
ND
LL
EHR
G
V
Y
A
Q
LH
K
M
Q
FG
fig|478008.5.peg.2583
Escherichia coli O157:H7 str. EC869 (11-581/582)
Q
TFRRL
------
W
PTIAPFKA
G
L
IVA
GVAL
-
IL
NA
A
SDTF
ML
S
L
LK
P
----LLD
DG
FGK---
T
DRS
VL
V
W
M
P
LV
V
I
GL
MI
----
L
RG
--
ITS
Y
VSS
Y
CI
S
W
V
SG-
-
--K
VV
MT
M
R
R
R
LFGHMM
GM
P
V
SFFD
K
Q
S
TG
T
L
L
SR
I
T
Y
D
S
E
-------
Q
V
A
SSSSGALI
TVVR
EG
A
SI
I
G
---
L
F
I
MMF
YY
SWQL
-
SI
I
L
I
V
L
A
P
I
VS
I
AI
------
R
VVSK
RFR
NIS
K
NMQ
N
T
MG
QVTT
S
AEQ
M
LK
G
HKE
V
LI
FG
GQEVETKRFDK
VSN
R
MRLQ-----------G
M
K
MV
S
A
S
S
-
IS
DP
I
I
Q
L
IA
SLAL
--
AF
V
L
Y
A
A
S
FPS
V
M
D
SLT
A
G
T
I
T
V
V
F
S
SMI
A
L
MR
PL
KS
LT
NV
-------
N
A
QF
QR
GM
AA
CQTL
F
T
I
L
D
S
E
Q
EK
------
DEGK
R
VIE
R
A
T
G
DVE
FR
NV
T
FTYP
GR
D
V
PAL
R
NINL
K
IP
A
G
KT
VALVG
R
S
GSGKST
I
ASLI
T
R
F
YD
I
D
EGEI
L
M
DG
H
D
L
RE
Y
T
L
A
SLR
NQ
VA
L
VSQ
N
V
H
LF
N
DTVANNIA
YAR
TEQY
S
R
E
Q
IE
E
AAR
M
A
YAM
D
F
I
NK
M
DN
G
L
DT
V
I
GE
N
GV
L
LSGGQ
R
QRIAIARALL
RDSP
ILILDEATSA
L
D
TE
S
E
R
AIQ
A
AL
DELQ
K
N
RT
S
LVIAHRLSTI
E
K
ADEIVV
V
ED
G
V
IVERGTH
ND
LL
EHR
G
V
Y
A
Q
LH
K
M
Q
FG
fig|637388.3.peg.4492
Escherichia coli O157:H7 str. FRIK2000 (11-581/582)
Q
TFRRL
------
W
PTIAPFKA
G
L
IVA
GVAL
-
IL
NA
A
SDTF
ML
S
L
LK
P
----LLD
DG
FGK---
T
DRS
VL
V
W
M
P
LV
V
I
GL
MI
----
L
RG
--
ITS
Y
VSS
Y
CI
S
W
V
SG-
-
--K
VV
MT
M
R
R
R
LFGHMM
GM
P
V
SFFD
K
Q
S
TG
T
L
L
SR
I
T
Y
D
S
E
-------
Q
V
A
SSSSGALI
TVVR
EG
A
SI
I
G
---
L
F
I
MMF
YY
SWQL
-
SI
I
L
I
V
L
A
P
I
VS
I
AI
------
R
VVSK
RFR
NIS
K
NMQ
N
T
MG
QVTT
S
AEQ
M
LK
G
HKE
V
LI
FG
GQEVETKRFDK
VSN
R
MRLQ-----------G
M
K
MV
S
A
S
S
-
IS
DP
I
I
Q
L
IA
SLAL
--
AF
V
L
Y
A
A
S
FPS
V
M
D
SLT
A
G
T
I
T
V
V
F
S
SMI
A
L
MR
PL
KS
LT
NV
-------
N
A
QF
QR
GM
AA
CQTL
F
T
I
L
D
S
E
Q
EK
------
DEGK
R
VIE
R
A
T
G
DVE
FR
NV
T
FTYP
GR
D
V
PAL
R
NINL
K
IP
A
G
KT
VALVG
R
S
GSGKST
I
ASLI
T
R
F
YD
I
D
EGEI
L
M
DG
H
D
L
RE
Y
T
L
A
SLR
NQ
VA
L
VSQ
N
V
H
LF
N
DTVANNIA
YAR
TEQY
S
R
E
Q
IE
E
AAR
M
A
YAM
D
F
I
NK
M
DN
G
L
DT
V
I
GE
N
GV
L
LSGGQ
R
QRIAIARALL
RDSP
ILILDEATSA
L
D
TE
S
E
R
AIQ
A
AL
DELQ
K
N
RT
S
LVIAHRLSTI
E
K
ADEIVV
V
ED
G
V
IVERGTH
ND
LL
EHR
G
V
Y
A
Q
LH
K
M
Q
FG
fig|570506.3.peg.2014
Escherichia coli O157:H7 str. FRIK966 (11-581/582)
Q
TFRRL
------
W
PTIAPFKA
G
L
IVA
GVAL
-
IL
NA
A
SDTF
ML
S
L
LK
P
----LLD
DG
FGK---
T
DRS
VL
V
W
M
P
LV
V
I
GL
MI
----
L
RG
--
ITS
Y
VSS
Y
CI
S
W
V
SG-
-
--K
VV
MT
M
R
R
R
LFGHMM
GM
P
V
SFFD
K
Q
S
TG
T
L
L
SR
I
T
Y
D
S
E
-------
Q
V
A
SSSSGALI
TVVR
EG
A
SI
I
G
---
L
F
I
MMF
YY
SWQL
-
SI
I
L
I
V
L
A
P
I
VS
I
AI
------
R
VVSK
RFR
NIS
K
NMQ
N
T
MG
QVTT
S
AEQ
M
LK
G
HKE
V
LI
FG
GQEVETKRFDK
VSN
R
MRLQ-----------G
M
K
MV
S
A
S
S
-
IS
DP
I
I
Q
L
IA
SLAL
--
AF
V
L
Y
A
A
S
FPS
V
M
D
SLT
A
G
T
I
T
V
V
F
S
SMI
A
L
MR
PL
KS
LT
NV
-------
N
A
QF
QR
GM
AA
CQTL
F
T
I
L
D
S
E
Q
EK
------
DEGK
R
VIE
R
A
T
G
DVE
FR
NV
T
FTYP
GR
D
V
PAL
R
NINL
K
IP
A
G
KT
VALVG
R
S
GSGKST
I
ASLI
T
R
F
YD
I
D
EGEI
L
M
DG
H
D
L
RE
Y
T
L
A
SLR
NQ
VA
L
VSQ
N
V
H
LF
N
DTVANNIA
YAR
TEQY
S
R
E
Q
IE
E
AAR
M
A
YAM
D
F
I
NK
M
DN
G
L
DT
V
I
GE
N
GV
L
LSGGQ
R
QRIAIARALL
RDSP
ILILDEATSA
L
D
TE
S
E
R
AIQ
A
AL
DELQ
K
N
RT
S
LVIAHRLSTI
E
K
ADEIVV
V
ED
G
V
IVERGTH
ND
LL
EHR
G
V
Y
A
Q
LH
K
M
Q
FG
fig|386585.9.peg.1117
Escherichia coli O157:H7 str. Sakai (11-581/582)
Q
TFRRL
------
W
PTIAPFKA
G
L
IVA
GVAL
-
IL
NA
A
SDTF
ML
S
L
LK
P
----LLD
DG
FGK---
T
DRS
VL
V
W
M
P
LV
V
I
GL
MI
----
L
RG
--
ITS
Y
VSS
Y
CI
S
W
V
SG-
-
--K
VV
MT
M
R
R
R
LFGHMM
GM
P
V
SFFD
K
Q
S
TG
T
L
L
SR
I
T
Y
D
S
E
-------
Q
V
A
SSSSGALI
TVVR
EG
A
SI
I
G
---
L
F
I
MMF
YY
SWQL
-
SI
I
L
I
V
L
A
P
I
VS
I
AI
------
R
VVSK
RFR
NIS
K
NMQ
N
T
MG
QVTT
S
AEQ
M
LK
G
HKE
V
LI
FG
GQEVETKRFDK
VSN
R
MRLQ-----------G
M
K
MV
S
A
S
S
-
IS
DP
I
I
Q
L
IA
SLAL
--
AF
V
L
Y
A
A
S
FPS
V
M
D
SLT
A
G
T
I
T
V
V
F
S
SMI
A
L
MR
PL
KS
LT
NV
-------
N
A
QF
QR
GM
AA
CQTL
F
T
I
L
D
S
E
Q
EK
------
DEGK
R
VIE
R
A
T
G
DVE
FR
NV
T
FTYP
GR
D
V
PAL
R
NINL
K
IP
A
G
KT
VALVG
R
S
GSGKST
I
ASLI
T
R
F
YD
I
D
EGEI
L
M
DG
H
D
L
RE
Y
T
L
A
SLR
NQ
VA
L
VSQ
N
V
H
LF
N
DTVANNIA
YAR
TEQY
S
R
E
Q
IE
E
AAR
M
A
YAM
D
F
I
NK
M
DN
G
L
DT
V
I
GE
N
GV
L
LSGGQ
R
QRIAIARALL
RDSP
ILILDEATSA
L
D
TE
S
E
R
AIQ
A
AL
DELQ
K
N
RT
S
LVIAHRLSTI
E
K
ADEIVV
V
ED
G
V
IVERGTH
ND
LL
EHR
G
V
Y
A
Q
LH
K
M
Q
FG
fig|544404.4.peg.1028
Escherichia coli O157:H7 str. TW14359 (11-581/582)
Q
TFRRL
------
W
PTIAPFKA
G
L
IVA
GVAL
-
IL
NA
A
SDTF
ML
S
L
LK
P
----LLD
DG
FGK---
T
DRS
VL
V
W
M
P
LV
V
I
GL
MI
----
L
RG
--
ITS
Y
VSS
Y
CI
S
W
V
SG-
-
--K
VV
MT
M
R
R
R
LFGHMM
GM
P
V
SFFD
K
Q
S
TG
T
L
L
SR
I
T
Y
D
S
E
-------
Q
V
A
SSSSGALI
TVVR
EG
A
SI
I
G
---
L
F
I
MMF
YY
SWQL
-
SI
I
L
I
V
L
A
P
I
VS
I
AI
------
R
VVSK
RFR
NIS
K
NMQ
N
T
MG
QVTT
S
AEQ
M
LK
G
HKE
V
LI
FG
GQEVETKRFDK
VSN
R
MRLQ-----------G
M
K
MV
S
A
S
S
-
IS
DP
I
I
Q
L
IA
SLAL
--
AF
V
L
Y
A
A
S
FPS
V
M
D
SLT
A
G
T
I
T
V
V
F
S
SMI
A
L
MR
PL
KS
LT
NV
-------
N
A
QF
QR
GM
AA
CQTL
F
T
I
L
D
S
E
Q
EK
------
DEGK
R
VIE
R
A
T
G
DVE
FR
NV
T
FTYP
GR
D
V
PAL
R
NINL
K
IP
A
G
KT
VALVG
R
S
GSGKST
I
ASLI
T
R
F
YD
I
D
EGEI
L
M
DG
H
D
L
RE
Y
T
L
A
SLR
NQ
VA
L
VSQ
N
V
H
LF
N
DTVANNIA
YAR
TEQY
S
R
E
Q
IE
E
AAR
M
A
YAM
D
F
I
NK
M
DN
G
L
DT
V
I
GE
N
GV
L
LSGGQ
R
QRIAIARALL
RDSP
ILILDEATSA
L
D
TE
S
E
R
AIQ
A
AL
DELQ
K
N
RT
S
LVIAHRLSTI
E
K
ADEIVV
V
ED
G
V
IVERGTH
ND
LL
EHR
G
V
Y
A
Q
LH
K
M
Q
FG
fig|502346.5.peg.173
Escherichia coli O157:H7 str. TW14588 (11-581/582)
Q
TFRRL
------
W
PTIAPFKA
G
L
IVA
GVAL
-
IL
NA
A
SDTF
ML
S
L
LK
P
----LLD
DG
FGK---
T
DRS
VL
V
W
M
P
LV
V
I
GL
MI
----
L
RG
--
ITS
Y
VSS
Y
CI
S
W
V
SG-
-
--K
VV
MT
M
R
R
R
LFGHMM
GM
P
V
SFFD
K
Q
S
TG
T
L
L
SR
I
T
Y
D
S
E
-------
Q
V
A
SSSSGALI
TVVR
EG
A
SI
I
G
---
L
F
I
MMF
YY
SWQL
-
SI
I
L
I
V
L
A
P
I
VS
I
AI
------
R
VVSK
RFR
NIS
K
NMQ
N
T
MG
QVTT
S
AEQ
M
LK
G
HKE
V
LI
FG
GQEVETKRFDK
VSN
R
MRLQ-----------G
M
K
MV
S
A
S
S
-
IS
DP
I
I
Q
L
IA
SLAL
--
AF
V
L
Y
A
A
S
FPS
V
M
D
SLT
A
G
T
I
T
V
V
F
S
SMI
A
L
MR
PL
KS
LT
NV
-------
N
A
QF
QR
GM
AA
CQTL
F
T
I
L
D
S
E
Q
EK
------
DEGK
R
VIE
R
A
T
G
DVE
FR
NV
T
FTYP
GR
D
V
PAL
R
NINL
K
IP
A
G
KT
VALVG
R
S
GSGKST
I
ASLI
T
R
F
YD
I
D
EGEI
L
M
DG
H
D
L
RE
Y
T
L
A
SLR
NQ
VA
L
VSQ
N
V
H
LF
N
DTVANNIA
YAR
TEQY
S
R
E
Q
IE
E
AAR
M
A
YAM
D
F
I
NK
M
DN
G
L
DT
V
I
GE
N
GV
L
LSGGQ
R
QRIAIARALL
RDSP
ILILDEATSA
L
D
TE
S
E
R
AIQ
A
AL
DELQ
K
N
RT
S
LVIAHRLSTI
E
K
ADEIVV
V
ED
G
V
IVERGTH
ND
LL
EHR
G
V
Y
A
Q
LH
K
M
Q
FG
fig|573235.3.peg.1065
Escherichia coli O26:H11 str. 11368 (11-581/582)
Q
TFRRL
------
W
PTIAPFKA
G
L
IVA
GVAL
-
IL
NA
A
SDTF
ML
S
L
LK
P
----LLD
DG
FGK---
T
DRS
VL
V
W
M
P
LV
V
I
GL
MI
----
L
RG
--
ITS
Y
VSS
Y
CI
S
W
V
SG-
-
--K
VV
MT
M
R
R
R
LFGHMM
GM
P
V
SFFD
K
Q
S
TG
T
L
L
SR
I
T
Y
D
S
E
-------
Q
V
A
SSSSGALI
TVVR
EG
A
SI
I
G
---
L
F
I
MMF
YY
SWQL
-
SI
I
L
I
V
L
A
P
I
VS
I
AI
------
R
VVSK
RFR
NIS
K
NMQ
N
T
MG
QVTT
S
AEQ
M
LK
G
HKE
V
LI
FG
GQEVETKRFDK
VSN
R
MRLQ-----------G
M
K
MV
S
A
S
S
-
IS
DP
I
I
Q
L
IA
SLAL
--
AF
V
L
Y
A
A
S
FPS
V
M
D
SLT
A
G
T
I
T
V
V
F
S
SMI
A
L
MR
PL
KS
LT
NV
-------
N
A
QF
QR
GM
AA
CQTL
F
T
I
L
D
S
E
Q
EK
------
DEGK
R
VIE
R
A
T
G
DVE
FR
NV
T
FTYP
GR
D
V
PAL
R
NINL
K
IP
A
G
KT
VALVG
R
S
GSGKST
I
ASLI
T
R
F
YD
I
D
EGEI
L
M
DG
H
D
L
RE
Y
T
L
A
SLR
NQ
VA
L
VSQ
N
V
H
LF
N
DTVANNIA
YAR
TEQY
S
R
E
Q
IE
E
AAR
M
A
YAM
D
F
I
NK
M
DN
G
L
DT
V
I
GE
N
GV
L
LSGGQ
R
QRIAIARALL
RDSP
ILILDEATSA
L
D
TE
S
E
R
AIQ
A
AL
DELQ
K
N
RT
S
LVIAHRLSTI
E
K
ADEIVV
V
ED
G
V
IVERGTH
ND
LL
EHR
G
V
Y
A
Q
LH
K
M
Q
FG
fig|701177.3.peg.1133
Escherichia coli O55:H7 str. CB9615 (11-581/582)
Q
TFRRL
------
W
PTIAPFKA
G
L
IVA
GVAL
-
IL
NA
A
SDTF
ML
S
L
LK
P
----LLD
DG
FGK---
T
DRS
VL
V
W
M
P
LV
V
I
GL
MI
----
L
RG
--
ITS
Y
VSS
Y
CI
S
W
V
SG-
-
--K
VV
MT
M
R
R
R
LFGHMM
GM
P
V
SFFD
K
Q
S
TG
T
L
L
SR
I
T
Y
D
S
E
-------
Q
V
A
SSSSGALI
TVVR
EG
A
SI
I
G
---
L
F
I
MMF
YY
SWQL
-
SI
I
L
I
V
L
A
P
I
VS
I
AI
------
R
VVSK
RFR
NIS
K
NMQ
N
T
MG
QVTT
S
AEQ
M
LK
G
HKE
V
LI
FG
GQEVETKRFDK
VSN
R
MRLQ-----------G
M
K
MV
S
A
S
S
-
IS
DP
I
I
Q
L
IA
SLAL
--
AF
V
L
Y
A
A
S
FPS
V
M
D
SLT
A
G
T
I
T
V
V
F
S
SMI
A
L
MR
PL
KS
LT
NV
-------
N
A
QF
QR
GM
AA
CQTL
F
T
I
L
D
S
E
Q
EK
------
DEGK
R
VIE
R
A
T
G
DVE
FR
NV
T
FTYP
GR
D
V
PAL
R
NINL
K
IP
A
G
KT
VALVG
R
S
GSGKST
I
ASLI
T
R
F
YD
I
D
EGEI
L
M
DG
H
D
L
RE
Y
T
L
A
SLR
NQ
VA
L
VSQ
N
V
H
LF
N
DTVANNIA
YAR
TEQY
S
R
E
Q
IE
E
AAR
M
A
YAM
D
F
I
NK
M
DN
G
L
DT
V
I
GE
N
GV
L
LSGGQ
R
QRIAIARALL
RDSP
ILILDEATSA
L
D
TE
S
E
R
AIQ
A
AL
DELQ
K
N
RT
S
LVIAHRLSTI
E
K
ADEIVV
V
ED
G
V
IVERGTH
ND
LL
EHR
G
V
Y
A
Q
LH
K
M
Q
FG
fig|637912.3.peg.28
Escherichia coli OP50 (11-581/582)
Q
TFRRL
------
W
PTIAPFKA
G
L
IVA
GVAL
-
IL
NA
A
SDTF
ML
S
L
LK
P
----LLD
DG
FGK---
T
DRS
VL
V
W
M
P
LV
V
I
GL
MI
----
L
RG
--
ITS
Y
VSS
Y
CI
S
W
V
SG-
-
--K
VV
MT
M
R
R
R
LFGHMM
GM
P
V
SFFD
K
Q
S
TG
T
L
L
SR
I
T
Y
D
S
E
-------
Q
V
A
SSSSGALI
TVVR
EG
A
SI
I
G
---
L
F
I
MMF
YY
SWQL
-
SI
I
L
I
V
L
A
P
I
VS
I
AI
------
R
VVSK
RFR
NIS
K
NMQ
N
T
MG
QVTT
S
AEQ
M
LK
G
HKE
V
LI
FG
GQEVETKRFDK
VSN
R
MRLQ-----------G
M
K
MV
S
A
S
S
-
IS
DP
I
I
Q
L
IA
SLAL
--
AF
V
L
Y
A
A
S
FPS
V
M
D
SLT
A
G
T
I
T
V
V
F
S
SMI
A
L
MR
PL
KS
LT
NV
-------
N
A
QF
QR
GM
AA
CQTL
F
T
I
L
D
S
E
Q
EK
------
DEGK
R
VIE
R
A
T
G
DVE
FR
NV
T
FTYP
GR
D
V
PAL
R
NINL
K
IP
A
G
KT
VALVG
R
S
GSGKST
I
ASLI
T
R
F
YD
I
D
EGEI
L
M
DG
H
D
L
RE
Y
T
L
A
SLR
NQ
VA
L
VSQ
N
V
H
LF
N
DTVANNIA
YAR
TEQY
S
R
E
Q
IE
E
AAR
M
A
YAM
D
F
I
NK
M
DN
G
L
DT
V
I
GE
N
GV
L
LSGGQ
R
QRIAIARALL
RDSP
ILILDEATSA
L
D
TE
S
E
R
AIQ
A
AL
DELQ
K
N
RT
S
LVIAHRLSTI
E
K
ADEIVV
V
ED
G
V
IVERGTH
ND
LL
EHR
G
V
Y
A
Q
LH
K
M
Q
FG
fig|409438.11.peg.1104
Escherichia coli SE11 (11-581/582)
Q
TFRRL
------
W
PTIAPFKA
G
L
IVA
GVAL
-
IL
NA
A
SDTF
ML
S
L
LK
P
----LLD
DG
FGK---
T
DRS
VL
V
W
M
P
LV
V
I
GL
MI
----
L
RG
--
ITS
Y
VSS
Y
CI
S
W
V
SG-
-
--K
VV
MT
M
R
R
R
LFGHMM
GM
P
V
SFFD
K
Q
S
TG
T
L
L
SR
I
T
Y
D
S
E
-------
Q
V
A
SSSSGALI
TVVR
EG
A
SI
I
G
---
L
F
I
MMF
YY
SWQL
-
SI
I
L
I
V
L
A
P
I
VS
I
AI
------
R
VVSK
RFR
NIS
K
NMQ
N
T
MG
QVTT
S
AEQ
M
LK
G
HKE
V
LI
FG
GQEVETKRFDK
VSN
R
MRLQ-----------G
M
K
MV
S
A
S
S
-
IS
DP
I
I
Q
L
IA
SLAL
--
AF
V
L
Y
A
A
S
FPS
V
M
D
SLT
A
G
T
I
T
V
V
F
S
SMI
A
L
MR
PL
KS
LT
NV
-------
N
A
QF
QR
GM
AA
CQTL
F
T
I
L
D
S
E
Q
EK
------
DEGK
R
VIE
R
A
T
G
DVE
FR
NV
T
FTYP
GR
D
V
PAL
R
NINL
K
IP
A
G
KT
VALVG
R
S
GSGKST
I
ASLI
T
R
F
YD
I
D
EGEI
L
M
DG
H
D
L
RE
Y
T
L
A
SLR
NQ
VA
L
VSQ
N
V
H
LF
N
DTVANNIA
YAR
TEQY
S
R
E
Q
IE
E
AAR
M
A
YAM
D
F
I
NK
M
DN
G
L
DT
V
I
GE
N
GV
L
LSGGQ
R
QRIAIARALL
RDSP
ILILDEATSA
L
D
TE
S
E
R
AIQ
A
AL
DELQ
K
N
RT
S
LVIAHRLSTI
E
K
ADEIVV
V
ED
G
V
IVERGTH
ND
LL
EHR
G
V
Y
A
Q
LH
K
M
Q
FG
fig|439855.10.peg.2361
Escherichia coli SMS-3-5 (11-581/582)
Q
TFRRL
------
W
PTIAPFKA
G
L
IVA
GVAL
-
IL
NA
A
SDTF
ML
S
L
LK
P
----LLD
DG
FGK---
T
DRS
VL
V
W
M
P
LV
V
I
GL
MI
----
L
RG
--
ITS
Y
VSS
Y
CI
S
W
V
SG-
-
--K
VV
MT
M
R
R
R
LFGHMM
GM
P
V
SFFD
K
Q
S
TG
T
L
L
SR
I
T
Y
D
S
E
-------
Q
V
A
SSSSGALI
TVVR
EG
A
SI
I
G
---
L
F
I
MMF
YY
SWQL
-
SI
I
L
I
V
L
A
P
I
VS
I
AI
------
R
VVSK
RFR
NIS
K
NMQ
N
T
MG
QVTT
S
AEQ
M
LK
G
HKE
V
LI
FG
GQEVETKRFDK
VSN
R
MRLQ-----------G
M
K
MV
S
A
S
S
-
IS
DP
I
I
Q
L
IA
SLAL
--
AF
V
L
Y
A
A
S
FPS
V
M
D
SLT
A
G
T
I
T
V
V
F
S
SMI
A
L
MR
PL
KS
LT
NV
-------
N
A
QF
QR
GM
AA
CQTL
F
T
I
L
D
S
E
Q
EK
------
DEGK
R
VIE
R
A
T
G
DVE
FR
NV
T
FTYP
GR
D
V
PAL
R
NINL
K
IP
A
G
KT
VALVG
R
S
GSGKST
I
ASLI
T
R
F
YD
I
D
EGEI
L
M
DG
H
D
L
RE
Y
T
L
A
SLR
NQ
VA
L
VSQ
N
V
H
LF
N
DTVANNIA
YAR
TEQY
S
R
E
Q
IE
E
AAR
M
A
YAM
D
F
I
NK
M
DN
G
L
DT
V
I
GE
N
GV
L
LSGGQ
R
QRIAIARALL
RDSP
ILILDEATSA
L
D
TE
S
E
R
AIQ
A
AL
DELQ
K
N
RT
S
LVIAHRLSTI
E
K
ADEIVV
V
ED
G
V
IVERGTH
ND
LL
EHR
G
V
Y
A
Q
LH
K
M
Q
FG
fig|656443.3.peg.1204
Escherichia coli TA271 (11-581/582)
Q
TFRRL
------
W
PTIAPFKA
G
L
IVA
GVAL
-
IL
NA
A
SDTF
ML
S
L
LK
P
----LLD
DG
FGK---
T
DRS
VL
V
W
M
P
LV
V
I
GL
MI
----
L
RG
--
ITS
Y
VSS
Y
CI
S
W
V
SG-
-
--K
VV
MT
M
R
R
R
LFGHMM
GM
P
V
SFFD
K
Q
S
TG
T
L
L
SR
I
T
Y
D
S
E
-------
Q
V
A
SSSSGALI
TVVR
EG
A
SI
I
G
---
L
F
I
MMF
YY
SWQL
-
SI
I
L
I
V
L
A
P
I
VS
I
AI
------
R
VVSK
RFR
NIS
K
NMQ
N
T
MG
QVTT
S
AEQ
M
LK
G
HKE
V
LI
FG
GQEVETKRFDK
VSN
R
MRLQ-----------G
M
K
MV
S
A
S
S
-
IS
DP
I
I
Q
L
IA
SLAL
--
AF
V
L
Y
A
A
S
FPS
V
M
D
SLT
A
G
T
I
T
V
V
F
S
SMI
A
L
MR
PL
KS
LT
NV
-------
N
A
QF
QR
GM
AA
CQTL
F
T
I
L
D
S
E
Q
EK
------
DEGK
R
VIE
R
A
T
G
DVE
FR
NV
T
FTYP
GR
D
V
PAL
R
NINL
K
IP
A
G
KT
VALVG
R
S
GSGKST
I
ASLI
T
R
F
YD
I
D
EGEI
L
M
DG
H
D
L
RE
Y
T
L
A
SLR
NQ
VA
L
VSQ
N
V
H
LF
N
DTVANNIA
YAR
TEQY
S
R
E
Q
IE
E
AAR
M
A
YAM
D
F
I
NK
M
DN
G
L
DT
V
I
GE
N
GV
L
LSGGQ
R
QRIAIARALL
RDSP
ILILDEATSA
L
D
TE
S
E
R
AIQ
A
AL
DELQ
K
N
RT
S
LVIAHRLSTI
E
K
ADEIVV
V
ED
G
V
IVERGTH
ND
LL
EHR
G
V
Y
A
Q
LH
K
M
Q
FG
fig|566546.3.peg.1860
Escherichia coli W (11-581/582)
Q
TFRRL
------
W
PTIAPFKA
G
L
IVA
GVAL
-
IL
NA
A
SDTF
ML
S
L
LK
P
----LLD
DG
FGK---
T
DRS
VL
V
W
M
P
LV
V
I
GL
MI
----
L
RG
--
ITS
Y
VSS
Y
CI
S
W
V
SG-
-
--K
VV
MT
M
R
R
R
LFGHMM
GM
P
V
SFFD
K
Q
S
TG
T
L
L
SR
I
T
Y
D
S
E
-------
Q
V
A
SSSSGALI
TVVR
EG
A
SI
I
G
---
L
F
I
MMF
YY
SWQL
-
SI
I
L
I
V
L
A
P
I
VS
I
AI
------
R
VVSK
RFR
NIS
K
NMQ
N
T
MG
QVTT
S
AEQ
M
LK
G
HKE
V
LI
FG
GQEVETKRFDK
VSN
R
MRLQ-----------G
M
K
MV
S
A
S
S
-
IS
DP
I
I
Q
L
IA
SLAL
--
AF
V
L
Y
A
A
S
FPS
V
M
D
SLT
A
G
T
I
T
V
V
F
S
SMI
A
L
MR
PL
KS
LT
NV
-------
N
A
QF
QR
GM
AA
CQTL
F
T
I
L
D
S
E
Q
EK
------
DEGK
R
VIE
R
A
T
G
DVE
FR
NV
T
FTYP
GR
D
V
PAL
R
NINL
K
IP
A
G
KT
VALVG
R
S
GSGKST
I
ASLI
T
R
F
YD
I
D
EGEI
L
M
DG
H
D
L
RE
Y
T
L
A
SLR
NQ
VA
L
VSQ
N
V
H
LF
N
DTVANNIA
YAR
TEQY
S
R
E
Q
IE
E
AAR
M
A
YAM
D
F
I
NK
M
DN
G
L
DT
V
I
GE
N
GV
L
LSGGQ
R
QRIAIARALL
RDSP
ILILDEATSA
L
D
TE
S
E
R
AIQ
A
AL
DELQ
K
N
RT
S
LVIAHRLSTI
E
K
ADEIVV
V
ED
G
V
IVERGTH
ND
LL
EHR
G
V
Y
A
Q
LH
K
M
Q
FG
fig|566546.4.peg.1013
Escherichia coli W (11-581/582)
Q
TFRRL
------
W
PTIAPFKA
G
L
IVA
GVAL
-
IL
NA
A
SDTF
ML
S
L
LK
P
----LLD
DG
FGK---
T
DRS
VL
V
W
M
P
LV
V
I
GL
MI
----
L
RG
--
ITS
Y
VSS
Y
CI
S
W
V
SG-
-
--K
VV
MT
M
R
R
R
LFGHMM
GM
P
V
SFFD
K
Q
S
TG
T
L
L
SR
I
T
Y
D
S
E
-------
Q
V
A
SSSSGALI
TVVR
EG
A
SI
I
G
---
L
F
I
MMF
YY
SWQL
-
SI
I
L
I
V
L
A
P
I
VS
I
AI
------
R
VVSK
RFR
NIS
K
NMQ
N
T
MG
QVTT
S
AEQ
M
LK
G
HKE
V
LI
FG
GQEVETKRFDK
VSN
R
MRLQ-----------G
M
K
MV
S
A
S
S
-
IS
DP
I
I
Q
L
IA
SLAL
--
AF
V
L
Y
A
A
S
FPS
V
M
D
SLT
A
G
T
I
T
V
V
F
S
SMI
A
L
MR
PL
KS
LT
NV
-------
N
A
QF
QR
GM
AA
CQTL
F
T
I
L
D
S
E
Q
EK
------
DEGK
R
VIE
R
A
T
G
DVE
FR
NV
T
FTYP
GR
D
V
PAL
R
NINL
K
IP
A
G
KT
VALVG
R
S
GSGKST
I
ASLI
T
R
F
YD
I
D
EGEI
L
M
DG
H
D
L
RE
Y
T
L
A
SLR
NQ
VA
L
VSQ
N
V
H
LF
N
DTVANNIA
YAR
TEQY
S
R
E
Q
IE
E
AAR
M
A
YAM
D
F
I
NK
M
DN
G
L
DT
V
I
GE
N
GV
L
LSGGQ
R
QRIAIARALL
RDSP
ILILDEATSA
L
D
TE
S
E
R
AIQ
A
AL
DELQ
K
N
RT
S
LVIAHRLSTI
E
K
ADEIVV
V
ED
G
V
IVERGTH
ND
LL
EHR
G
V
Y
A
Q
LH
K
M
Q
FG
fig|316407.3.peg.880
Escherichia coli W3110 (11-581/582)
Q
TFRRL
------
W
PTIAPFKA
G
L
IVA
GVAL
-
IL
NA
A
SDTF
ML
S
L
LK
P
----LLD
DG
FGK---
T
DRS
VL
V
W
M
P
LV
V
I
GL
MI
----
L
RG
--
ITS
Y
VSS
Y
CI
S
W
V
SG-
-
--K
VV
MT
M
R
R
R
LFGHMM
GM
P
V
SFFD
K
Q
S
TG
T
L
L
SR
I
T
Y
D
S
E
-------
Q
V
A
SSSSGALI
TVVR
EG
A
SI
I
G
---
L
F
I
MMF
YY
SWQL
-
SI
I
L
I
V
L
A
P
I
VS
I
AI
------
R
VVSK
RFR
NIS
K
NMQ
N
T
MG
QVTT
S
AEQ
M
LK
G
HKE
V
LI
FG
GQEVETKRFDK
VSN
R
MRLQ-----------G
M
K
MV
S
A
S
S
-
IS
DP
I
I
Q
L
IA
SLAL
--
AF
V
L
Y
A
A
S
FPS
V
M
D
SLT
A
G
T
I
T
V
V
F
S
SMI
A
L
MR
PL
KS
LT
NV
-------
N
A
QF
QR
GM
AA
CQTL
F
T
I
L
D
S
E
Q
EK
------
DEGK
R
VIE
R
A
T
G
DVE
FR
NV
T
FTYP
GR
D
V
PAL
R
NINL
K
IP
A
G
KT
VALVG
R
S
GSGKST
I
ASLI
T
R
F
YD
I
D
EGEI
L
M
DG
H
D
L
RE
Y
T
L
A
SLR
NQ
VA
L
VSQ
N
V
H
LF
N
DTVANNIA
YAR
TEQY
S
R
E
Q
IE
E
AAR
M
A
YAM
D
F
I
NK
M
DN
G
L
DT
V
I
GE
N
GV
L
LSGGQ
R
QRIAIARALL
RDSP
ILILDEATSA
L
D
TE
S
E
R
AIQ
A
AL
DELQ
K
N
RT
S
LVIAHRLSTI
E
K
ADEIVV
V
ED
G
V
IVERGTH
ND
LL
EHR
G
V
Y
A
Q
LH
K
M
Q
FG
fig|316385.7.peg.996
Escherichia coli str. K-12 substr. DH10B (11-581/582)
Q
TFRRL
------
W
PTIAPFKA
G
L
IVA
GVAL
-
IL
NA
A
SDTF
ML
S
L
LK
P
----LLD
DG
FGK---
T
DRS
VL
V
W
M
P
LV
V
I
GL
MI
----
L
RG
--
ITS
Y
VSS
Y
CI
S
W
V
SG-
-
--K
VV
MT
M
R
R
R
LFGHMM
GM
P
V
SFFD
K
Q
S
TG
T
L
L
SR
I
T
Y
D
S
E
-------
Q
V
A
SSSSGALI
TVVR
EG
A
SI
I
G
---
L
F
I
MMF
YY
SWQL
-
SI
I
L
I
V
L
A
P
I
VS
I
AI
------
R
VVSK
RFR
NIS
K
NMQ
N
T
MG
QVTT
S
AEQ
M
LK
G
HKE
V
LI
FG
GQEVETKRFDK
VSN
R
MRLQ-----------G
M
K
MV
S
A
S
S
-
IS
DP
I
I
Q
L
IA
SLAL
--
AF
V
L
Y
A
A
S
FPS
V
M
D
SLT
A
G
T
I
T
V
V
F
S
SMI
A
L
MR
PL
KS
LT
NV
-------
N
A
QF
QR
GM
AA
CQTL
F
T
I
L
D
S
E
Q
EK
------
DEGK
R
VIE
R
A
T
G
DVE
FR
NV
T
FTYP
GR
D
V
PAL
R
NINL
K
IP
A
G
KT
VALVG
R
S
GSGKST
I
ASLI
T
R
F
YD
I
D
EGEI
L
M
DG
H
D
L
RE
Y
T
L
A
SLR
NQ
VA
L
VSQ
N
V
H
LF
N
DTVANNIA
YAR
TEQY
S
R
E
Q
IE
E
AAR
M
A
YAM
D
F
I
NK
M
DN
G
L
DT
V
I
GE
N
GV
L
LSGGQ
R
QRIAIARALL
RDSP
ILILDEATSA
L
D
TE
S
E
R
AIQ
A
AL
DELQ
K
N
RT
S
LVIAHRLSTI
E
K
ADEIVV
V
ED
G
V
IVERGTH
ND
LL
EHR
G
V
Y
A
Q
LH
K
M
Q
FG
fig|511145.12.peg.945
Escherichia coli str. K-12 substr. MG1655 (11-581/582)
Q
TFRRL
------
W
PTIAPFKA
G
L
IVA
GVAL
-
IL
NA
A
SDTF
ML
S
L
LK
P
----LLD
DG
FGK---
T
DRS
VL
V
W
M
P
LV
V
I
GL
MI
----
L
RG
--
ITS
Y
VSS
Y
CI
S
W
V
SG-
-
--K
VV
MT
M
R
R
R
LFGHMM
GM
P
V
SFFD
K
Q
S
TG
T
L
L
SR
I
T
Y
D
S
E
-------
Q
V
A
SSSSGALI
TVVR
EG
A
SI
I
G
---
L
F
I
MMF
YY
SWQL
-
SI
I
L
I
V
L
A
P
I
VS
I
AI
------
R
VVSK
RFR
NIS
K
NMQ
N
T
MG
QVTT
S
AEQ
M
LK
G
HKE
V
LI
FG
GQEVETKRFDK
VSN
R
MRLQ-----------G
M
K
MV
S
A
S
S
-
IS
DP
I
I
Q
L
IA
SLAL
--
AF
V
L
Y
A
A
S
FPS
V
M
D
SLT
A
G
T
I
T
V
V
F
S
SMI
A
L
MR
PL
KS
LT
NV
-------
N
A
QF
QR
GM
AA
CQTL
F
T
I
L
D
S
E
Q
EK
------
DEGK
R
VIE
R
A
T
G
DVE
FR
NV
T
FTYP
GR
D
V
PAL
R
NINL
K
IP
A
G
KT
VALVG
R
S
GSGKST
I
ASLI
T
R
F
YD
I
D
EGEI
L
M
DG
H
D
L
RE
Y
T
L
A
SLR
NQ
VA
L
VSQ
N
V
H
LF
N
DTVANNIA
YAR
TEQY
S
R
E
Q
IE
E
AAR
M
A
YAM
D
F
I
NK
M
DN
G
L
DT
V
I
GE
N
GV
L
LSGGQ
R
QRIAIARALL
RDSP
ILILDEATSA
L
D
TE
S
E
R
AIQ
A
AL
DELQ
K
N
RT
S
LVIAHRLSTI
E
K
ADEIVV
V
ED
G
V
IVERGTH
ND
LL
EHR
G
V
Y
A
Q
LH
K
M
Q
FG
fig|511145.6.peg.938
Escherichia coli str. K-12 substr. MG1655 (11-581/582)
Q
TFRRL
------
W
PTIAPFKA
G
L
IVA
GVAL
-
IL
NA
A
SDTF
ML
S
L
LK
P
----LLD
DG
FGK---
T
DRS
VL
V
W
M
P
LV
V
I
GL
MI
----
L
RG
--
ITS
Y
VSS
Y
CI
S
W
V
SG-
-
--K
VV
MT
M
R
R
R
LFGHMM
GM
P
V
SFFD
K
Q
S
TG
T
L
L
SR
I
T
Y
D
S
E
-------
Q
V
A
SSSSGALI
TVVR
EG
A
SI
I
G
---
L
F
I
MMF
YY
SWQL
-
SI
I
L
I
V
L
A
P
I
VS
I
AI
------
R
VVSK
RFR
NIS
K
NMQ
N
T
MG
QVTT
S
AEQ
M
LK
G
HKE
V
LI
FG
GQEVETKRFDK
VSN
R
MRLQ-----------G
M
K
MV
S
A
S
S
-
IS
DP
I
I
Q
L
IA
SLAL
--
AF
V
L
Y
A
A
S
FPS
V
M
D
SLT
A
G
T
I
T
V
V
F
S
SMI
A
L
MR
PL
KS
LT
NV
-------
N
A
QF
QR
GM
AA
CQTL
F
T
I
L
D
S
E
Q
EK
------
DEGK
R
VIE
R
A
T
G
DVE
FR
NV
T
FTYP
GR
D
V
PAL
R
NINL
K
IP
A
G
KT
VALVG
R
S
GSGKST
I
ASLI
T
R
F
YD
I
D
EGEI
L
M
DG
H
D
L
RE
Y
T
L
A
SLR
NQ
VA
L
VSQ
N
V
H
LF
N
DTVANNIA
YAR
TEQY
S
R
E
Q
IE
E
AAR
M
A
YAM
D
F
I
NK
M
DN
G
L
DT
V
I
GE
N
GV
L
LSGGQ
R
QRIAIARALL
RDSP
ILILDEATSA
L
D
TE
S
E
R
AIQ
A
AL
DELQ
K
N
RT
S
LVIAHRLSTI
E
K
ADEIVV
V
ED
G
V
IVERGTH
ND
LL
EHR
G
V
Y
A
Q
LH
K
M
Q
FG
fig|216592.1.peg.205
Escherichia coli 042 (11-581/582)
Q
TFRRL
------
W
PTIAPFKA
G
L
IVA
GVAL
-
IL
NA
A
SDTF
ML
S
L
LK
P
----LLD
DG
FGK---
T
DRS
VL
V
W
M
P
LV
V
I
GL
MI
----
L
RG
--
ITS
Y
VSS
Y
CI
S
W
V
SG-
-
--K
VV
MT
M
R
R
R
LFGHMM
GM
P
V
SFFD
K
Q
S
TG
T
L
L
SR
I
T
Y
D
S
E
-------
Q
V
A
SSSSGALI
TVVR
EG
A
SI
I
G
---
L
F
I
MMF
YY
SWQL
-
SI
I
L
I
V
L
A
P
I
VS
I
AI
------
R
VVSK
RFR
NIS
K
NMQ
N
T
MG
QVTT
S
AEQ
M
LK
G
HKE
V
LI
FG
GQEVETKRFDK
VSN
R
MRLQ-----------G
M
K
MV
S
A
S
S
-
IS
DP
I
I
Q
L
IA
SLAL
--
AF
V
L
Y
A
A
S
FPS
V
M
D
N
LT
A
G
T
I
T
V
V
F
S
SMI
A
L
MR
PL
KS
LT
NV
-------
N
A
QF
QR
GM
AA
CQTL
F
T
I
L
D
S
E
Q
EK
------
DEGK
R
VIE
R
A
T
G
DVE
FR
NV
T
FTYP
GR
D
V
PAL
R
NINL
K
IP
A
G
KT
VALVG
R
S
GSGKST
I
ASLI
T
R
F
YD
I
D
EGEI
L
M
DG
H
D
L
RE
Y
T
L
A
SLR
NQ
VA
L
VSQ
N
V
H
LF
N
DTVANNIA
YAR
TEQY
S
R
E
Q
IE
E
AAR
M
A
YAM
D
F
I
NK
M
DN
G
L
DT
V
I
GE
N
GV
L
LSGGQ
R
QRIAIARALL
RDSP
ILILDEATSA
L
D
TE
S
E
R
AIQ
A
AL
DELQ
K
N
RT
S
LVIAHRLSTI
E
K
ADEIVV
V
ED
G
V
IVERGTH
ND
LL
EHR
G
V
Y
A
Q
LH
K
M
Q
FG
fig|216592.3.peg.1038
Escherichia coli 042 (11-581/582)
Q
TFRRL
------
W
PTIAPFKA
G
L
IVA
GVAL
-
IL
NA
A
SDTF
ML
S
L
LK
P
----LLD
DG
FGK---
T
DRS
VL
V
W
M
P
LV
V
I
GL
MI
----
L
RG
--
ITS
Y
VSS
Y
CI
S
W
V
SG-
-
--K
VV
MT
M
R
R
R
LFGHMM
GM
P
V
SFFD
K
Q
S
TG
T
L
L
SR
I
T
Y
D
S
E
-------
Q
V
A
SSSSGALI
TVVR
EG
A
SI
I
G
---
L
F
I
MMF
YY
SWQL
-
SI
I
L
I
V
L
A
P
I
VS
I
AI
------
R
VVSK
RFR
NIS
K
NMQ
N
T
MG
QVTT
S
AEQ
M
LK
G
HKE
V
LI
FG
GQEVETKRFDK
VSN
R
MRLQ-----------G
M
K
MV
S
A
S
S
-
IS
DP
I
I
Q
L
IA
SLAL
--
AF
V
L
Y
A
A
S
FPS
V
M
D
N
LT
A
G
T
I
T
V
V
F
S
SMI
A
L
MR
PL
KS
LT
NV
-------
N
A
QF
QR
GM
AA
CQTL
F
T
I
L
D
S
E
Q
EK
------
DEGK
R
VIE
R
A
T
G
DVE
FR
NV
T
FTYP
GR
D
V
PAL
R
NINL
K
IP
A
G
KT
VALVG
R
S
GSGKST
I
ASLI
T
R
F
YD
I
D
EGEI
L
M
DG
H
D
L
RE
Y
T
L
A
SLR
NQ
VA
L
VSQ
N
V
H
LF
N
DTVANNIA
YAR
TEQY
S
R
E
Q
IE
E
AAR
M
A
YAM
D
F
I
NK
M
DN
G
L
DT
V
I
GE
N
GV
L
LSGGQ
R
QRIAIARALL
RDSP
ILILDEATSA
L
D
TE
S
E
R
AIQ
A
AL
DELQ
K
N
RT
S
LVIAHRLSTI
E
K
ADEIVV
V
ED
G
V
IVERGTH
ND
LL
EHR
G
V
Y
A
Q
LH
K
M
Q
FG
fig|656379.3.peg.1764
Escherichia coli FVEC1302 (11-581/582)
Q
TFRRL
------
W
PTIAPFKA
G
L
IVA
GVAL
-
IL
NA
A
SDTF
ML
S
L
LK
P
----LLD
DG
FGK---
T
DRS
VL
V
W
M
P
LV
V
I
GL
MI
----
L
RG
--
ITS
Y
VSS
Y
CI
S
W
V
SG-
-
--K
VV
MT
M
R
R
R
LFGHMM
GM
P
V
SFFD
K
Q
S
TG
T
L
L
SR
I
T
Y
D
S
E
-------
Q
V
A
SSSSGALI
TVVR
EG
A
SI
I
G
---
L
F
I
MMF
YY
SWQL
-
SI
I
L
I
V
L
A
P
I
VS
I
AI
------
R
VVSK
RFR
NIS
K
NMQ
N
T
MG
QVTT
S
AEQ
M
LK
G
HKE
V
LI
FG
GQEVETKRFDK
VSN
R
MRLQ-----------G
M
K
MV
S
A
S
S
-
IS
DP
I
I
Q
L
IA
SLAL
--
AF
V
L
Y
A
A
S
FPS
V
M
D
N
LT
A
G
T
I
T
V
V
F
S
SMI
A
L
MR
PL
KS
LT
NV
-------
N
A
QF
QR
GM
AA
CQTL
F
T
I
L
D
S
E
Q
EK
------
DEGK
R
VIE
R
A
T
G
DVE
FR
NV
T
FTYP
GR
D
V
PAL
R
NINL
K
IP
A
G
KT
VALVG
R
S
GSGKST
I
ASLI
T
R
F
YD
I
D
EGEI
L
M
DG
H
D
L
RE
Y
T
L
A
SLR
NQ
VA
L
VSQ
N
V
H
LF
N
DTVANNIA
YAR
TEQY
S
R
E
Q
IE
E
AAR
M
A
YAM
D
F
I
NK
M
DN
G
L
DT
V
I
GE
N
GV
L
LSGGQ
R
QRIAIARALL
RDSP
ILILDEATSA
L
D
TE
S
E
R
AIQ
A
AL
DELQ
K
N
RT
S
LVIAHRLSTI
E
K
ADEIVV
V
ED
G
V
IVERGTH
ND
LL
EHR
G
V
Y
A
Q
LH
K
M
Q
FG
fig|656380.3.peg.1593
Escherichia coli FVEC1412 (11-581/582)
Q
TFRRL
------
W
PTIAPFKA
G
L
IVA
GVAL
-
IL
NA
A
SDTF
ML
S
L
LK
P
----LLD
DG
FGK---
T
DRS
VL
V
W
M
P
LV
V
I
GL
MI
----
L
RG
--
ITS
Y
VSS
Y
CI
S
W
V
SG-
-
--K
VV
MT
M
R
R
R
LFGHMM
GM
P
V
SFFD
K
Q
S
TG
T
L
L
SR
I
T
Y
D
S
E
-------
Q
V
A
SSSSGALI
TVVR
EG
A
SI
I
G
---
L
F
I
MMF
YY
SWQL
-
SI
I
L
I
V
L
A
P
I
VS
I
AI
------
R
VVSK
RFR
NIS
K
NMQ
N
T
MG
QVTT
S
AEQ
M
LK
G
HKE
V
LI
FG
GQEVETKRFDK
VSN
R
MRLQ-----------G
M
K
MV
S
A
S
S
-
IS
DP
I
I
Q
L
IA
SLAL
--
AF
V
L
Y
A
A
S
FPS
V
M
D
N
LT
A
G
T
I
T
V
V
F
S
SMI
A
L
MR
PL
KS
LT
NV
-------
N
A
QF
QR
GM
AA
CQTL
F
T
I
L
D
S
E
Q
EK
------
DEGK
R
VIE
R
A
T
G
DVE
FR
NV
T
FTYP
GR
D
V
PAL
R
NINL
K
IP
A
G
KT
VALVG
R
S
GSGKST
I
ASLI
T
R
F
YD
I
D
EGEI
L
M
DG
H
D
L
RE
Y
T
L
A
SLR
NQ
VA
L
VSQ
N
V
H
LF
N
DTVANNIA
YAR
TEQY
S
R
E
Q
IE
E
AAR
M
A
YAM
D
F
I
NK
M
DN
G
L
DT
V
I
GE
N
GV
L
LSGGQ
R
QRIAIARALL
RDSP
ILILDEATSA
L
D
TE
S
E
R
AIQ
A
AL
DELQ
K
N
RT
S
LVIAHRLSTI
E
K
ADEIVV
V
ED
G
V
IVERGTH
ND
LL
EHR
G
V
Y
A
Q
LH
K
M
Q
FG
fig|749549.3.peg.5305
Escherichia coli MS 198-1 (11-581/582)
Q
TFRRL
------
W
PTIAPFKA
G
L
IVA
GVAL
-
IL
NA
A
SDTF
ML
S
L
LK
P
----LLD
DG
FGK---
T
DRS
VL
V
W
M
P
LV
V
I
GL
MI
----
L
RG
--
ITS
Y
VSS
Y
CI
S
W
V
SG-
-
--K
VV
MT
M
R
R
R
LFGHMM
GM
P
V
SFFD
K
Q
S
TG
T
L
L
SR
I
T
Y
D
S
E
-------
Q
V
A
SSSSGALI
TVVR
EG
A
SI
I
G
---
L
F
I
MMF
YY
SWQL
-
SI
I
L
I
V
L
A
P
I
VS
I
AI
------
R
VVSK
RFR
NIS
K
NMQ
N
T
MG
QVTT
S
AEQ
M
LK
G
HKE
V
LI
FG
GQEVETKRFDK
VSN
R
MRLQ-----------G
M
K
MV
S
A
S
S
-
IS
DP
I
I
Q
L
IA
SLAL
--
AF
V
L
Y
A
A
S
FPS
V
M
D
N
LT
A
G
T
I
T
V
V
F
S
SMI
A
L
MR
PL
KS
LT
NV
-------
N
A
QF
QR
GM
AA
CQTL
F
T
I
L
D
S
E
Q
EK
------
DEGK
R
VIE
R
A
T
G
DVE
FR
NV
T
FTYP
GR
D
V
PAL
R
NINL
K
IP
A
G
KT
VALVG
R
S
GSGKST
I
ASLI
T
R
F
YD
I
D
EGEI
L
M
DG
H
D
L
RE
Y
T
L
A
SLR
NQ
VA
L
VSQ
N
V
H
LF
N
DTVANNIA
YAR
TEQY
S
R
E
Q
IE
E
AAR
M
A
YAM
D
F
I
NK
M
DN
G
L
DT
V
I
GE
N
GV
L
LSGGQ
R
QRIAIARALL
RDSP
ILILDEATSA
L
D
TE
S
E
R
AIQ
A
AL
DELQ
K
N
RT
S
LVIAHRLSTI
E
K
ADEIVV
V
ED
G
V
IVERGTH
ND
LL
EHR
G
V
Y
A
Q
LH
K
M
Q
FG
fig|749531.3.peg.3115
Escherichia coli MS 69-1 (11-581/582)
Q
TFRRL
------
W
PTIAPFKA
G
L
IVA
GVAL
-
IL
NA
A
SDTF
ML
S
L
LK
P
----LLD
DG
FGK---
T
DRS
VL
V
W
M
P
LV
V
I
GL
MI
----
L
RG
--
ITS
Y
VSS
Y
CI
S
W
V
SG-
-
--K
VV
MT
M
R
R
R
LFGHMM
GM
P
V
SFFD
K
Q
S
TG
T
L
L
SR
I
T
Y
D
S
E
-------
Q
V
A
SSSSGALI
TVVR
EG
A
SI
I
G
---
L
F
I
MMF
YY
SWQL
-
SI
I
L
I
V
L
A
P
I
VS
I
AI
------
R
VVSK
RFR
NIS
K
NMQ
N
T
MG
QVTT
S
AEQ
M
LK
G
HKE
V
LI
FG
GQEVETKRFDK
VSN
R
MRLQ-----------G
M
K
MV
S
A
S
S
-
IS
DP
I
I
Q
L
IA
SLAL
--
AF
V
L
Y
A
A
S
FPS
V
M
D
N
LT
A
G
T
I
T
V
V
F
S
SMI
A
L
MR
PL
KS
LT
NV
-------
N
A
QF
QR
GM
AA
CQTL
F
T
I
L
D
S
E
Q
EK
------
DEGK
R
VIE
R
A
T
G
DVE
FR
NV
T
FTYP
GR
D
V
PAL
R
NINL
K
IP
A
G
KT
VALVG
R
S
GSGKST
I
ASLI
T
R
F
YD
I
D
EGEI
L
M
DG
H
D
L
RE
Y
T
L
A
SLR
NQ
VA
L
VSQ
N
V
H
LF
N
DTVANNIA
YAR
TEQY
S
R
E
Q
IE
E
AAR
M
A
YAM
D
F
I
NK
M
DN
G
L
DT
V
I
GE
N
GV
L
LSGGQ
R
QRIAIARALL
RDSP
ILILDEATSA
L
D
TE
S
E
R
AIQ
A
AL
DELQ
K
N
RT
S
LVIAHRLSTI
E
K
ADEIVV
V
ED
G
V
IVERGTH
ND
LL
EHR
G
V
Y
A
Q
LH
K
M
Q
FG
fig|656437.3.peg.1052
Escherichia coli TA143 (11-581/582)
Q
TFRRL
------
W
PTIAPFKA
G
L
IVA
GVAL
-
IL
NA
A
SDTF
ML
S
L
LK
P
----LLD
DG
FGK---
T
DRS
VL
V
W
M
P
LV
V
I
GL
MI
----
L
RG
--
ITS
Y
VSS
Y
CI
S
W
V
SG-
-
--K
VV
MT
M
R
R
R
LFGHMM
GM
P
V
SFFD
K
Q
S
TG
T
L
L
SR
I
T
Y
D
S
E
-------
Q
V
A
SSSSGALI
TVVR
EG
A
SI
I
G
---
L
F
I
MMF
YY
SWQL
-
SI
I
L
I
V
L
A
P
I
VS
I
AI
------
R
VVSK
RFR
NIS
K
NMQ
N
T
MG
QVTT
S
AEQ
M
LK
G
HKE
V
LI
FG
GQEVETKRFDK
VSN
R
MRLQ-----------G
M
K
MV
S
A
S
S
-
IS
DP
I
I
Q
L
IA
SLAL
--
AF
V
L
Y
A
A
S
FPS
V
M
D
N
LT
A
G
T
I
T
V
V
F
S
SMI
A
L
MR
PL
KS
LT
NV
-------
N
A
QF
QR
GM
AA
CQTL
F
T
I
L
D
S
E
Q
EK
------
DEGK
R
VIE
R
A
T
G
DVE
FR
NV
T
FTYP
GR
D
V
PAL
R
NINL
K
IP
A
G
KT
VALVG
R
S
GSGKST
I
ASLI
T
R
F
YD
I
D
EGEI
L
M
DG
H
D
L
RE
Y
T
L
A
SLR
NQ
VA
L
VSQ
N
V
H
LF
N
DTVANNIA
YAR
TEQY
S
R
E
Q
IE
E
AAR
M
A
YAM
D
F
I
NK
M
DN
G
L
DT
V
I
GE
N
GV
L
LSGGQ
R
QRIAIARALL
RDSP
ILILDEATSA
L
D
TE
S
E
R
AIQ
A
AL
DELQ
K
N
RT
S
LVIAHRLSTI
E
K
ADEIVV
V
ED
G
V
IVERGTH
ND
LL
EHR
G
V
Y
A
Q
LH
K
M
Q
FG
fig|656444.3.peg.1534
Escherichia coli TA280 (11-581/582)
Q
TFRRL
------
W
PTIAPFKA
G
L
IVA
GVAL
-
IL
NA
A
SDTF
ML
S
L
LK
P
----LLD
DG
FGK---
T
DRS
VL
V
W
M
P
LV
V
I
GL
MI
----
L
RG
--
ITS
Y
VSS
Y
CI
S
W
V
SG-
-
--K
VV
MT
M
R
R
R
LFGHMM
GM
P
V
SFFD
K
Q
S
TG
T
L
L
SR
I
T
Y
D
S
E
-------
Q
V
A
SSSSGALI
TVVR
EG
A
SI
I
G
---
L
F
I
MMF
YY
SWQL
-
SI
I
L
I
V
L
A
P
I
VS
I
AI
------
R
VVSK
RFR
NIS
K
NMQ
N
T
MG
QVTT
S
AEQ
M
LK
G
HKE
V
LI
FG
GQEVETKRFDK
VSN
R
MRLQ-----------G
M
K
MV
S
A
S
S
-
IS
DP
I
I
Q
L
IA
SLAL
--
AF
V
L
Y
A
A
S
FPS
V
M
D
N
LT
A
G
T
I
T
V
V
F
S
SMI
A
L
MR
PL
KS
LT
NV
-------
N
A
QF
QR
GM
AA
CQTL
F
T
I
L
D
S
E
Q
EK
------
DEGK
R
VIE
R
A
T
G
DVE
FR
NV
T
FTYP
GR
D
V
PAL
R
NINL
K
IP
A
G
KT
VALVG
R
S
GSGKST
I
ASLI
T
R
F
YD
I
D
EGEI
L
M
DG
H
D
L
RE
Y
T
L
A
SLR
NQ
VA
L
VSQ
N
V
H
LF
N
DTVANNIA
YAR
TEQY
S
R
E
Q
IE
E
AAR
M
A
YAM
D
F
I
NK
M
DN
G
L
DT
V
I
GE
N
GV
L
LSGGQ
R
QRIAIARALL
RDSP
ILILDEATSA
L
D
TE
S
E
R
AIQ
A
AL
DELQ
K
N
RT
S
LVIAHRLSTI
E
K
ADEIVV
V
ED
G
V
IVERGTH
ND
LL
EHR
G
V
Y
A
Q
LH
K
M
Q
FG
fig|585056.7.peg.1302
Escherichia coli UMN026 (11-581/582)
Q
TFRRL
------
W
PTIAPFKA
G
L
IVA
GVAL
-
IL
NA
A
SDTF
ML
S
L
LK
P
----LLD
DG
FGK---
T
DRS
VL
V
W
M
P
LV
V
I
GL
MI
----
L
RG
--
ITS
Y
VSS
Y
CI
S
W
V
SG-
-
--K
VV
MT
M
R
R
R
LFGHMM
GM
P
V
SFFD
K
Q
S
TG
T
L
L
SR
I
T
Y
D
S
E
-------
Q
V
A
SSSSGALI
TVVR
EG
A
SI
I
G
---
L
F
I
MMF
YY
SWQL
-
SI
I
L
I
V
L
A
P
I
VS
I
AI
------
R
VVSK
RFR
NIS
K
NMQ
N
T
MG
QVTT
S
AEQ
M
LK
G
HKE
V
LI
FG
GQEVETKRFDK
VSN
R
MRLQ-----------G
M
K
MV
S
A
S
S
-
IS
DP
I
I
Q
L
IA
SLAL
--
AF
V
L
Y
A
A
S
FPS
V
M
D
N
LT
A
G
T
I
T
V
V
F
S
SMI
A
L
MR
PL
KS
LT
NV
-------
N
A
QF
QR
GM
AA
CQTL
F
T
I
L
D
S
E
Q
EK
------
DEGK
R
VIE
R
A
T
G
DVE
FR
NV
T
FTYP
GR
D
V
PAL
R
NINL
K
IP
A
G
KT
VALVG
R
S
GSGKST
I
ASLI
T
R
F
YD
I
D
EGEI
L
M
DG
H
D
L
RE
Y
T
L
A
SLR
NQ
VA
L
VSQ
N
V
H
LF
N
DTVANNIA
YAR
TEQY
S
R
E
Q
IE
E
AAR
M
A
YAM
D
F
I
NK
M
DN
G
L
DT
V
I
GE
N
GV
L
LSGGQ
R
QRIAIARALL
RDSP
ILILDEATSA
L
D
TE
S
E
R
AIQ
A
AL
DELQ
K
N
RT
S
LVIAHRLSTI
E
K
ADEIVV
V
ED
G
V
IVERGTH
ND
LL
EHR
G
V
Y
A
Q
LH
K
M
Q
FG
fig|316401.4.peg.1131
Escherichia coli ETEC H10407 (11-581/582)
Q
TFRRL
------
W
PTIAPFKA
G
L
IVA
GVAL
-
IL
NA
A
SDTF
ML
S
L
LK
P
----LLD
DG
FGK---
T
DRS
VL
V
W
M
P
LV
V
I
GL
MI
----
L
RG
--
ITS
Y
VSS
Y
CI
S
W
V
SG-
-
--K
VV
MT
M
R
R
R
LFGHMM
GM
P
V
SFFD
K
Q
S
TG
T
L
L
SR
I
T
Y
D
S
E
-------
Q
V
A
SSSSGALI
A
VVR
EG
A
SI
I
G
---
L
F
I
MMF
YY
SWQL
-
SI
I
L
I
V
L
A
P
I
VS
I
AI
------
R
VVSK
RFR
NIS
K
NMQ
N
T
MG
QVTT
S
AEQ
M
LK
G
HKE
V
LI
FG
GQEVETKRFDK
VSN
R
MRLQ-----------G
M
K
MV
S
A
S
S
-
IS
DP
I
I
Q
L
IA
SLAL
--
AF
V
L
Y
A
A
S
FPS
V
M
D
SLT
A
G
T
I
T
V
V
F
S
SMI
A
L
MR
PL
KS
LT
NV
-------
N
A
QF
QR
GM
AA
CQTL
F
T
I
L
D
S
E
Q
EK
------
DEGK
R
VIE
R
A
T
G
DVE
FR
NV
T
FTYP
GR
D
V
PAL
R
NINL
K
IP
A
G
KT
VALVG
R
S
GSGKST
I
ASLI
T
R
F
YD
I
D
EGEI
L
M
DG
H
D
L
RE
Y
T
L
A
SLR
NQ
VA
L
VSQ
N
V
H
LF
N
DTVANNIA
YAR
TEQY
S
R
E
Q
IE
E
AAR
M
A
YAM
D
F
I
NK
M
DN
G
L
DT
V
I
GE
N
GV
L
LSGGQ
R
QRIAIARALL
RDSP
ILILDEATSA
L
D
TE
S
E
R
AIQ
A
AL
DELQ
K
N
RT
S
LVIAHRLSTI
E
K
ADEIVV
V
ED
G
V
IVERGTH
ND
LL
EHR
G
V
Y
A
Q
LH
K
M
Q
FG
fig|358709.5.peg.3430
Escherichia coli 101-1 (11-581/582)
Q
TFRRL
------
W
PTIAPFKA
G
L
IVA
GVAL
-
IL
NA
A
SDTF
ML
S
L
LK
P
----LLD
DG
FGK---
T
DRS
VL
V
W
M
P
LV
V
I
GL
MI
----
L
RG
--
ITS
Y
VSS
Y
CI
S
W
V
SG-
-
--K
VV
MT
M
R
R
R
LFGHMM
GM
P
V
SFFD
K
Q
S
TG
T
L
L
SR
I
T
Y
D
S
E
-------
Q
V
A
SSSSGALI
TVVR
EG
A
SI
I
G
---
L
F
I
MMF
YY
SWQL
-
SI
I
L
I
V
L
A
P
I
VS
I
AI
------
R
VVSK
RFR
NIS
K
NMQ
N
T
MG
QVTT
S
AEQ
M
LK
G
HKE
V
LI
FG
GQEVETKRFDK
VSN
R
MRLQ-----------G
M
K
MV
S
A
S
S
-
IS
DP
I
I
Q
L
IA
SLAL
--
AF
V
L
Y
A
A
S
FPS
V
M
D
SLT
A
G
T
I
T
V
V
F
S
SMI
A
L
MR
PL
KS
LT
NV
-------
N
A
QF
QR
GM
AA
CQTL
F
T
I
L
D
S
E
Q
EK
------
DEGK
R
VIE
R
A
T
G
DVE
FR
NV
T
FTYP
GR
D
V
PAL
RS
INL
K
IP
A
G
KT
VALVG
R
S
GSGKST
I
ASLI
T
R
F
YD
I
D
EGEI
L
M
DG
H
D
L
RE
Y
T
L
A
SLR
NQ
VA
L
VSQ
N
V
H
LF
N
DTVANNIA
YAR
TEQY
S
R
E
Q
IE
E
AAR
M
A
YAM
D
F
I
NK
M
DN
G
L
DT
V
I
GE
N
GV
L
LSGGQ
R
QRIAIARALL
RDSP
ILILDEATSA
L
D
TE
S
E
R
AIQ
A
AL
DELQ
K
N
RT
S
LVIAHRLSTI
E
K
ADEIVV
V
ED
G
V
IVERGTH
ND
LL
EHR
G
V
Y
A
Q
LH
K
M
Q
FG
fig|656393.3.peg.1099
Escherichia coli H299 (1-586/590)
MR
L
F
A
QL
S
W
Y
FRR
E
------
W
--------
R
R
YLG
A
VALL
VI
--
-
--IA
ML
Q
L
VP
P
KVVGIVV
DG
VTEQHF
T
TGQ
I
L
M
W
I
A
TM
V
L
--
--
----
-
--
IA
VVV
Y
LLR
Y
VW
R
V
L
LFG
A
SYQ
LA
VE
LR
E
D
YYRQLS
RQ
H
P
E
F
YL
R
H
R
TG
D
L
M
A
R
A
TND
V
D
-------
R
VV
FAAGEGVL
T
L
V
-
-D
S
LV
M
G
CAV
L
I
M
M
ST
QI
SWQL
---
T
L
F
AL
L
P
M
PV
M
AI
MIKRNG
D
ALHE
RF
K
LAQ
A
AFS
S
L
ND
RTQE
S
LTS
I
--
-
-RM
I
KA
FG
-----------
LED
R
QSALFAEDAEDTGKKN
M
R
VA
R
I
D
A
-
RF
DP
T
I
Y
I
AI
GM
A
N
--
LL
A
I
G
G
G
S
WMV
V
Q
GSLT
L
G
Q
LT
S
F
M
M
YLG
L
M
IW
P
M
LA
L
A
WM
FNIVERG
S
A
AY
S
R
IR
A
M
LAEA
P
V
V
N
DG
S
E
PV
PE
----
----
-
--G
RG
E
L
DV
N
IR
--
Q
FTYP
QT
D
H
PAL
E
N
V
N
F
A
L
K
P
G
QM
V
GIC
G
P
TGSGKSTL
L
SLI
Q
R
H
F
D
V
S
EG
D
IR
F
HD
I
PL
TK
L
Q
L
D
S
W
R
SR
L
A
V
VSQ
T
P
F
LF
S
DTVANNIALG
-
CPNA
T
Q
Q
E
IE
H
V
AR
L
A
SVH
D
D
I
LR
L
PQ
G
Y
N
T
E
V
GE
R
GV
M
LSGGQKQRI
S
IARALL
VNAE
ILILD
D
A
L
SA
V
D
GR
TE
H
Q
I
L
H
N
L
RQWG
Q
G
RT
V
I
IS
AHRLS
AL
T
E
A
S
EI
I
V
M
QH
G
H
I
AQ
RG
N
H
DE
L
A
QQS
G
W
Y
R
D
MY
R
Y
Q
QL
EAA
L
DDAPE
I
R
E
E
fig|585057.4.peg.244
Escherichia coli IAI39 (1-586/590)
MR
L
F
A
QL
S
W
Y
FRR
E
------
W
--------
R
R
YLG
A
VALL
VI
--
-
--IA
ML
Q
L
VP
P
KVVGIVV
DG
VTEQHF
T
TGQ
I
L
M
W
I
A
TM
V
L
--
--
----
-
--
IA
VVV
Y
LLR
Y
VW
R
V
L
LFG
A
SYQ
LA
VE
LR
E
D
YYRQLS
RQ
H
P
E
F
YL
R
H
R
TG
D
L
M
A
R
A
TND
V
D
-------
R
VV
FAAGEGVL
T
L
V
-
-D
S
LV
M
G
CAV
L
I
M
M
ST
QI
SWQL
---
T
L
F
AL
L
P
M
PV
M
AI
MIKRNG
D
ALHE
RF
K
LAQ
A
AFS
S
L
ND
RTQE
S
LTS
I
--
-
-RM
I
KA
FG
-----------
LED
R
QSALFAADAEDTGKKN
M
R
VA
R
I
D
A
-
RF
DP
T
I
Y
I
AI
GM
A
N
--
LL
A
I
G
G
G
S
WMV
V
Q
GSLT
L
G
Q
LT
S
F
M
M
YLG
L
M
IW
P
M
LA
L
A
WM
FNIVERG
S
A
AY
S
R
IR
S
M
LAEA
P
V
V
N
DG
S
D
PV
P
Q
----
----
-
--G
RG
E
L
DV
N
IR
--
Q
FTYP
QT
D
H
PAL
E
NIN
F
A
L
K
P
G
QM
LGIC
G
P
TGSGKSTL
L
SLI
Q
R
H
F
D
V
S
EGEIR
F
HD
I
PL
PQ
L
Q
L
D
S
W
R
SR
L
A
V
VSQ
T
P
F
LF
S
DTVANNIALG
-
CPNA
T
Q
Q
E
IE
H
V
AR
L
A
SVH
D
D
I
LR
L
PQ
G
Y
DT
E
V
GE
R
GV
M
LSGGQKQRI
S
IARALL
VNAE
ILILD
D
A
L
SA
V
D
GR
TE
H
Q
I
L
H
N
L
RQWG
Q
G
RT
V
I
IS
AHRLS
AL
T
E
A
S
EI
I
V
M
QH
G
H
I
AQ
RG
N
H
DE
L
A
QQS
G
W
Y
R
D
MY
R
Y
Q
QL
EAA
L
DDAPE
I
R
E
E
fig|585057.6.peg.243
Escherichia coli IAI39 (1-586/590)
MR
L
F
A
QL
S
W
Y
FRR
E
------
W
--------
R
R
YLG
A
VALL
VI
--
-
--IA
ML
Q
L
VP
P
KVVGIVV
DG
VTEQHF
T
TGQ
I
L
M
W
I
A
TM
V
L
--
--
----
-
--
IA
VVV
Y
LLR
Y
VW
R
V
L
LFG
A
SYQ
LA
VE
LR
E
D
YYRQLS
RQ
H
P
E
F
YL
R
H
R
TG
D
L
M
A
R
A
TND
V
D
-------
R
VV
FAAGEGVL
T
L
V
-
-D
S
LV
M
G
CAV
L
I
M
M
ST
QI
SWQL
---
T
L
F
AL
L
P
M
PV
M
AI
MIKRNG
D
ALHE
RF
K
LAQ
A
AFS
S
L
ND
RTQE
S
LTS
I
--
-
-RM
I
KA
FG
-----------
LED
R
QSALFAADAEDTGKKN
M
R
VA
R
I
D
A
-
RF
DP
T
I
Y
I
AI
GM
A
N
--
LL
A
I
G
G
G
S
WMV
V
Q
GSLT
L
G
Q
LT
S
F
M
M
YLG
L
M
IW
P
M
LA
L
A
WM
FNIVERG
S
A
AY
S
R
IR
S
M
LAEA
P
V
V
N
DG
S
D
PV
P
Q
----
----
-
--G
RG
E
L
DV
N
IR
--
Q
FTYP
QT
D
H
PAL
E
NIN
F
A
L
K
P
G
QM
LGIC
G
P
TGSGKSTL
L
SLI
Q
R
H
F
D
V
S
EGEIR
F
HD
I
PL
PQ
L
Q
L
D
S
W
R
SR
L
A
V
VSQ
T
P
F
LF
S
DTVANNIALG
-
CPNA
T
Q
Q
E
IE
H
V
AR
L
A
SVH
D
D
I
LR
L
PQ
G
Y
DT
E
V
GE
R
GV
M
LSGGQKQRI
S
IARALL
VNAE
ILILD
D
A
L
SA
V
D
GR
TE
H
Q
I
L
H
N
L
RQWG
Q
G
RT
V
I
IS
AHRLS
AL
T
E
A
S
EI
I
V
M
QH
G
H
I
AQ
RG
N
H
DE
L
A
QQS
G
W
Y
R
D
MY
R
Y
Q
QL
EAA
L
DDAPE
I
R
E
E
fig|670897.3.peg.271
Escherichia coli 2362-75 (1-586/590)
MR
L
F
A
QL
S
W
Y
FRR
E
------
W
--------
R
R
YLG
A
VALL
VI
--
-
--IA
ML
Q
L
VP
P
KVVGIVV
DG
VTEQHF
T
TGQ
I
L
M
W
I
A
TM
V
L
--
--
----
-
--
IA
VVV
Y
LLR
Y
VW
R
V
L
LFG
A
SYQ
LA
VE
LR
E
D
YYRQLS
RQ
H
P
E
F
YL
R
H
R
TG
D
L
M
A
R
A
TND
V
D
-------
R
VV
FAAGEGVL
T
L
V
-
-D
S
LV
M
G
CAV
L
I
M
M
ST
QI
SWQL
---
T
L
F
AL
L
P
M
PV
M
AI
MIKRNG
D
ALHE
RF
K
LAQ
A
AFS
S
L
ND
RTQE
S
LTS
I
--
-
-RM
I
KA
FG
-----------
LED
R
QSALFAADAEDTGKKN
M
R
VA
R
I
D
A
-
RF
DP
T
I
Y
I
AI
GM
A
N
--
LL
A
I
G
G
G
S
WMV
V
Q
GSLT
L
G
Q
LT
S
F
M
M
YLG
L
M
IW
P
M
LA
L
A
WM
FNIVERG
S
A
AY
S
R
IR
T
M
LAEA
P
V
V
I
DG
S
D
KV
PE
----
----
-
--G
RG
E
L
DV
N
IR
--
Q
FTYP
QT
D
H
PAL
E
N
V
N
F
A
L
K
P
G
QM
V
GIC
G
P
TGSGKSTL
L
SLI
Q
R
H
F
D
V
S
EG
D
IR
F
HD
I
PL
TK
L
Q
L
D
S
W
R
SR
L
A
V
VSQ
T
P
F
LF
S
DTVANNIALG
-
CPNA
T
Q
Q
E
IE
H
V
AR
L
A
SVH
D
D
I
LR
L
PQ
G
Y
DT
E
V
GE
R
GV
M
LSGGQKQRI
S
IARALL
VNAE
ILILD
D
A
L
SA
V
D
GR
TE
H
Q
I
L
H
N
L
RQWG
Q
G
RT
V
I
IS
AHRLS
AL
T
E
A
S
EI
I
V
M
QH
G
H
I
AQ
RG
N
H
DE
L
A
QQS
G
W
Y
R
D
MY
R
Y
Q
QL
EAA
L
DDAPE
I
R
E
E
fig|362663.8.peg.509
Escherichia coli 536 (1-586/590)
MR
L
F
A
QL
S
W
Y
FRR
E
------
W
--------
R
R
YLG
A
VALL
VI
--
-
--IA
ML
Q
L
VP
P
KVVGIVV
DG
VTEQHF
T
TGQ
I
L
M
W
I
A
TM
V
L
--
--
----
-
--
IA
VVV
Y
LLR
Y
VW
R
V
L
LFG
A
SYQ
LA
VE
LR
E
D
YYRQLS
RQ
H
P
E
F
YL
R
H
R
TG
D
L
M
A
R
A
TND
V
D
-------
R
VV
FAAGEGVL
T
L
V
-
-D
S
LV
M
G
CAV
L
I
M
M
ST
QI
SWQL
---
T
L
F
AL
L
P
M
PV
M
AI
MIKRNG
D
ALHE
RF
K
LAQ
A
AFS
S
L
ND
RTQE
S
LTS
I
--
-
-RM
I
KA
FG
-----------
LED
R
QSALFAADAEDTGKKN
M
R
VA
R
I
D
A
-
RF
DP
T
I
Y
I
AI
GM
A
N
--
LL
A
I
G
G
G
S
WMV
V
Q
GSLT
L
G
Q
LT
S
F
M
M
YLG
L
M
IW
P
M
LA
L
A
WM
FNIVERG
S
A
AY
S
R
IR
T
M
LAEA
P
V
V
I
DG
S
D
KV
PE
----
----
-
--G
RG
E
L
DV
N
IR
--
Q
FTYP
QT
D
H
PAL
E
N
V
N
F
A
L
K
P
G
QM
V
GIC
G
P
TGSGKSTL
L
SLI
Q
R
H
F
D
V
S
EG
D
IR
F
HD
I
PL
TK
L
Q
L
D
S
W
R
SR
L
A
V
VSQ
T
P
F
LF
S
DTVANNIALG
-
CPNA
T
Q
Q
E
IE
H
V
AR
L
A
SVH
D
D
I
LR
L
PQ
G
Y
DT
E
V
GE
R
GV
M
LSGGQKQRI
S
IARALL
VNAE
ILILD
D
A
L
SA
V
D
GR
TE
H
Q
I
L
H
N
L
RQWG
Q
G
RT
V
I
IS
AHRLS
AL
T
E
A
S
EI
I
V
M
QH
G
H
I
AQ
RG
N
H
DE
L
A
QQS
G
W
Y
R
D
MY
R
Y
Q
QL
EAA
L
DDAPE
I
R
E
E
fig|362663.9.peg.509
Escherichia coli 536 (1-586/590)
MR
L
F
A
QL
S
W
Y
FRR
E
------
W
--------
R
R
YLG
A
VALL
VI
--
-
--IA
ML
Q
L
VP
P
KVVGIVV
DG
VTEQHF
T
TGQ
I
L
M
W
I
A
TM
V
L
--
--
----
-
--
IA
VVV
Y
LLR
Y
VW
R
V
L
LFG
A
SYQ
LA
VE
LR
E
D
YYRQLS
RQ
H
P
E
F
YL
R
H
R
TG
D
L
M
A
R
A
TND
V
D
-------
R
VV
FAAGEGVL
T
L
V
-
-D
S
LV
M
G
CAV
L
I
M
M
ST
QI
SWQL
---
T
L
F
AL
L
P
M
PV
M
AI
MIKRNG
D
ALHE
RF
K
LAQ
A
AFS
S
L
ND
RTQE
S
LTS
I
--
-
-RM
I
KA
FG
-----------
LED
R
QSALFAADAEDTGKKN
M
R
VA
R
I
D
A
-
RF
DP
T
I
Y
I
AI
GM
A
N
--
LL
A
I
G
G
G
S
WMV
V
Q
GSLT
L
G
Q
LT
S
F
M
M
YLG
L
M
IW
P
M
LA
L
A
WM
FNIVERG
S
A
AY
S
R
IR
T
M
LAEA
P
V
V
I
DG
S
D
KV
PE
----
----
-
--G
RG
E
L
DV
N
IR
--
Q
FTYP
QT
D
H
PAL
E
N
V
N
F
A
L
K
P
G
QM
V
GIC
G
P
TGSGKSTL
L
SLI
Q
R
H
F
D
V
S
EG
D
IR
F
HD
I
PL
TK
L
Q
L
D
S
W
R
SR
L
A
V
VSQ
T
P
F
LF
S
DTVANNIALG
-
CPNA
T
Q
Q
E
IE
H
V
AR
L
A
SVH
D
D
I
LR
L
PQ
G
Y
DT
E
V
GE
R
GV
M
LSGGQKQRI
S
IARALL
VNAE
ILILD
D
A
L
SA
V
D
GR
TE
H
Q
I
L
H
N
L
RQWG
Q
G
RT
V
I
IS
AHRLS
AL
T
E
A
S
EI
I
V
M
QH
G
H
I
AQ
RG
N
H
DE
L
A
QQS
G
W
Y
R
D
MY
R
Y
Q
QL
EAA
L
DDAPE
I
R
E
E
fig|525281.3.peg.2457
Escherichia coli 83972 (1-586/590)
MR
L
F
A
QL
S
W
Y
FRR
E
------
W
--------
R
R
YLG
A
VALL
VI
--
-
--IA
ML
Q
L
VP
P
KVVGIVV
DG
VTEQHF
T
TGQ
I
L
M
W
I
A
TM
V
L
--
--
----
-
--
IA
VVV
Y
LLR
Y
VW
R
V
L
LFG
A
SYQ
LA
VE
LR
E
D
YYRQLS
RQ
H
P
E
F
YL
R
H
R
TG
D
L
M
A
R
A
TND
V
D
-------
R
VV
FAAGEGVL
T
L
V
-
-D
S
LV
M
G
CAV
L
I
M
M
ST
QI
SWQL
---
T
L
F
AL
L
P
M
PV
M
AI
MIKRNG
D
ALHE
RF
K
LAQ
A
AFS
S
L
ND
RTQE
S
LTS
I
--
-
-RM
I
KA
FG
-----------
LED
R
QSALFAADAEDTGKKN
M
R
VA
R
I
D
A
-
RF
DP
T
I
Y
I
AI
GM
A
N
--
LL
A
I
G
G
G
S
WMV
V
Q
GSLT
L
G
Q
LT
S
F
M
M
YLG
L
M
IW
P
M
LA
L
A
WM
FNIVERG
S
A
AY
S
R
IR
T
M
LAEA
P
V
V
I
DG
S
D
KV
PE
----
----
-
--G
RG
E
L
DV
N
IR
--
Q
FTYP
QT
D
H
PAL
E
N
V
N
F
A
L
K
P
G
QM
V
GIC
G
P
TGSGKSTL
L
SLI
Q
R
H
F
D
V
S
EG
D
IR
F
HD
I
PL
TK
L
Q
L
D
S
W
R
SR
L
A
V
VSQ
T
P
F
LF
S
DTVANNIALG
-
CPNA
T
Q
Q
E
IE
H
V
AR
L
A
SVH
D
D
I
LR
L
PQ
G
Y
DT
E
V
GE
R
GV
M
LSGGQKQRI
S
IARALL
VNAE
ILILD
D
A
L
SA
V
D
GR
TE
H
Q
I
L
H
N
L
RQWG
Q
G
RT
V
I
IS
AHRLS
AL
T
E
A
S
EI
I
V
M
QH
G
H
I
AQ
RG
N
H
DE
L
A
QQS
G
W
Y
R
D
MY
R
Y
Q
QL
EAA
L
DDAPE
I
R
E
E
fig|655817.3.peg.566
Escherichia coli ABU 83972 (1-586/590)
MR
L
F
A
QL
S
W
Y
FRR
E
------
W
--------
R
R
YLG
A
VALL
VI
--
-
--IA
ML
Q
L
VP
P
KVVGIVV
DG
VTEQHF
T
TGQ
I
L
M
W
I
A
TM
V
L
--
--
----
-
--
IA
VVV
Y
LLR
Y
VW
R
V
L
LFG
A
SYQ
LA
VE
LR
E
D
YYRQLS
RQ
H
P
E
F
YL
R
H
R
TG
D
L
M
A
R
A
TND
V
D
-------
R
VV
FAAGEGVL
T
L
V
-
-D
S
LV
M
G
CAV
L
I
M
M
ST
QI
SWQL
---
T
L
F
AL
L
P
M
PV
M
AI
MIKRNG
D
ALHE
RF
K
LAQ
A
AFS
S
L
ND
RTQE
S
LTS
I
--
-
-RM
I
KA
FG
-----------
LED
R
QSALFAADAEDTGKKN
M
R
VA
R
I
D
A
-
RF
DP
T
I
Y
I
AI
GM
A
N
--
LL
A
I
G
G
G
S
WMV
V
Q
GSLT
L
G
Q
LT
S
F
M
M
YLG
L
M
IW
P
M
LA
L
A
WM
FNIVERG
S
A
AY
S
R
IR
T
M
LAEA
P
V
V
I
DG
S
D
KV
PE
----
----
-
--G
RG
E
L
DV
N
IR
--
Q
FTYP
QT
D
H
PAL
E
N
V
N
F
A
L
K
P
G
QM
V
GIC
G
P
TGSGKSTL
L
SLI
Q
R
H
F
D
V
S
EG
D
IR
F
HD
I
PL
TK
L
Q
L
D
S
W
R
SR
L
A
V
VSQ
T
P
F
LF
S
DTVANNIALG
-
CPNA
T
Q
Q
E
IE
H
V
AR
L
A
SVH
D
D
I
LR
L
PQ
G
Y
DT
E
V
GE
R
GV
M
LSGGQKQRI
S
IARALL
VNAE
ILILD
D
A
L
SA
V
D
GR
TE
H
Q
I
L
H
N
L
RQWG
Q
G
RT
V
I
IS
AHRLS
AL
T
E
A
S
EI
I
V
M
QH
G
H
I
AQ
RG
N
H
DE
L
A
QQS
G
W
Y
R
D
MY
R
Y
Q
QL
EAA
L
DDAPE
I
R
E
E
fig|199310.1.peg.543
Escherichia coli CFT073 (1-586/590)
MR
L
F
A
QL
S
W
Y
FRR
E
------
W
--------
R
R
YLG
A
VALL
VI
--
-
--IA
ML
Q
L
VP
P
KVVGIVV
DG
VTEQHF
T
TGQ
I
L
M
W
I
A
TM
V
L
--
--
----
-
--
IA
VVV
Y
LLR
Y
VW
R
V
L
LFG
A
SYQ
LA
VE
LR
E
D
YYRQLS
RQ
H
P
E
F
YL
R
H
R
TG
D
L
M
A
R
A
TND
V
D
-------
R
VV
FAAGEGVL
T
L
V
-
-D
S
LV
M
G
CAV
L
I
M
M
ST
QI
SWQL
---
T
L
F
AL
L
P
M
PV
M
AI
MIKRNG
D
ALHE
RF
K
LAQ
A
AFS
S
L
ND
RTQE
S
LTS
I
--
-
-RM
I
KA
FG
-----------
LED
R
QSALFAADAEDTGKKN
M
R
VA
R
I
D
A
-
RF
DP
T
I
Y
I
AI
GM
A
N
--
LL
A
I
G
G
G
S
WMV
V
Q
GSLT
L
G
Q
LT
S
F
M
M
YLG
L
M
IW
P
M
LA
L
A
WM
FNIVERG
S
A
AY
S
R
IR
T
M
LAEA
P
V
V
I
DG
S
D
KV
PE
----
----
-
--G
RG
E
L
DV
N
IR
--
Q
FTYP
QT
D
H
PAL
E
N
V
N
F
A
L
K
P
G
QM
V
GIC
G
P
TGSGKSTL
L
SLI
Q
R
H
F
D
V
S
EG
D
IR
F
HD
I
PL
TK
L
Q
L
D
S
W
R
SR
L
A
V
VSQ
T
P
F
LF
S
DTVANNIALG
-
CPNA
T
Q
Q
E
IE
H
V
AR
L
A
SVH
D
D
I
LR
L
PQ
G
Y
DT
E
V
GE
R
GV
M
LSGGQKQRI
S
IARALL
VNAE
ILILD
D
A
L
SA
V
D
GR
TE
H
Q
I
L
H
N
L
RQWG
Q
G
RT
V
I
IS
AHRLS
AL
T
E
A
S
EI
I
V
M
QH
G
H
I
AQ
RG
N
H
DE
L
A
QQS
G
W
Y
R
D
MY
R
Y
Q
QL
EAA
L
DDAPE
I
R
E
E
fig|199310.4.peg.530
Escherichia coli CFT073 (1-586/590)
MR
L
F
A
QL
S
W
Y
FRR
E
------
W
--------
R
R
YLG
A
VALL
VI
--
-
--IA
ML
Q
L
VP
P
KVVGIVV
DG
VTEQHF
T
TGQ
I
L
M
W
I
A
TM
V
L
--
--
----
-
--
IA
VVV
Y
LLR
Y
VW
R
V
L
LFG
A
SYQ
LA
VE
LR
E
D
YYRQLS
RQ
H
P
E
F
YL
R
H
R
TG
D
L
M
A
R
A
TND
V
D
-------
R
VV
FAAGEGVL
T
L
V
-
-D
S
LV
M
G
CAV
L
I
M
M
ST
QI
SWQL
---
T
L
F
AL
L
P
M
PV
M
AI
MIKRNG
D
ALHE
RF
K
LAQ
A
AFS
S
L
ND
RTQE
S
LTS
I
--
-
-RM
I
KA
FG
-----------
LED
R
QSALFAADAEDTGKKN
M
R
VA
R
I
D
A
-
RF
DP
T
I
Y
I
AI
GM
A
N
--
LL
A
I
G
G
G
S
WMV
V
Q
GSLT
L
G
Q
LT
S
F
M
M
YLG
L
M
IW
P
M
LA
L
A
WM
FNIVERG
S
A
AY
S
R
IR
T
M
LAEA
P
V
V
I
DG
S
D
KV
PE
----
----
-
--G
RG
E
L
DV
N
IR
--
Q
FTYP
QT
D
H
PAL
E
N
V
N
F
A
L
K
P
G
QM
V
GIC
G
P
TGSGKSTL
L
SLI
Q
R
H
F
D
V
S
EG
D
IR
F
HD
I
PL
TK
L
Q
L
D
S
W
R
SR
L
A
V
VSQ
T
P
F
LF
S
DTVANNIALG
-
CPNA
T
Q
Q
E
IE
H
V
AR
L
A
SVH
D
D
I
LR
L
PQ
G
Y
DT
E
V
GE
R
GV
M
LSGGQKQRI
S
IARALL
VNAE
ILILD
D
A
L
SA
V
D
GR
TE
H
Q
I
L
H
N
L
RQWG
Q
G
RT
V
I
IS
AHRLS
AL
T
E
A
S
EI
I
V
M
QH
G
H
I
AQ
RG
N
H
DE
L
A
QQS
G
W
Y
R
D
MY
R
Y
Q
QL
EAA
L
DDAPE
I
R
E
E
fig|340197.3.peg.3779
Escherichia coli F11 (1-586/590)
MR
L
F
A
QL
S
W
Y
FRR
E
------
W
--------
R
R
YLG
A
VALL
VI
--
-
--IA
ML
Q
L
VP
P
KVVGIVV
DG
VTEQHF
T
TGQ
I
L
M
W
I
A
TM
V
L
--
--
----
-
--
IA
VVV
Y
LLR
Y
VW
R
V
L
LFG
A
SYQ
LA
VE
LR
E
D
YYRQLS
RQ
H
P
E
F
YL
R
H
R
TG
D
L
M
A
R
A
TND
V
D
-------
R
VV
FAAGEGVL
T
L
V
-
-D
S
LV
M
G
CAV
L
I
M
M
ST
QI
SWQL
---
T
L
F
AL
L
P
M
PV
M
AI
MIKRNG
D
ALHE
RF
K
LAQ
A
AFS
S
L
ND
RTQE
S
LTS
I
--
-
-RM
I
KA
FG
-----------
LED
R
QSALFAADAEDTGKKN
M
R
VA
R
I
D
A
-
RF
DP
T
I
Y
I
AI
GM
A
N
--
LL
A
I
G
G
G
S
WMV
V
Q
GSLT
L
G
Q
LT
S
F
M
M
YLG
L
M
IW
P
M
LA
L
A
WM
FNIVERG
S
A
AY
S
R
IR
T
M
LAEA
P
V
V
I
DG
S
D
KV
PE
----
----
-
--G
RG
E
L
DV
N
IR
--
Q
FTYP
QT
D
H
PAL
E
N
V
N
F
A
L
K
P
G
QM
V
GIC
G
P
TGSGKSTL
L
SLI
Q
R
H
F
D
V
S
EG
D
IR
F
HD
I
PL
TK
L
Q
L
D
S
W
R
SR
L
A
V
VSQ
T
P
F
LF
S
DTVANNIALG
-
CPNA
T
Q
Q
E
IE
H
V
AR
L
A
SVH
D
D
I
LR
L
PQ
G
Y
DT
E
V
GE
R
GV
M
LSGGQKQRI
S
IARALL
VNAE
ILILD
D
A
L
SA
V
D
GR
TE
H
Q
I
L
H
N
L
RQWG
Q
G
RT
V
I
IS
AHRLS
AL
T
E
A
S
EI
I
V
M
QH
G
H
I
AQ
RG
N
H
DE
L
A
QQS
G
W
Y
R
D
MY
R
Y
Q
QL
EAA
L
DDAPE
I
R
E
E
fig|340197.5.peg.3955
Escherichia coli F11 (1-586/590)
MR
L
F
A
QL
S
W
Y
FRR
E
------
W
--------
R
R
YLG
A
VALL
VI
--
-
--IA
ML
Q
L
VP
P
KVVGIVV
DG
VTEQHF
T
TGQ
I
L
M
W
I
A
TM
V
L
--
--
----
-
--
IA
VVV
Y
LLR
Y
VW
R
V
L
LFG
A
SYQ
LA
VE
LR
E
D
YYRQLS
RQ
H
P
E
F
YL
R
H
R
TG
D
L
M
A
R
A
TND
V
D
-------
R
VV
FAAGEGVL
T
L
V
-
-D
S
LV
M
G
CAV
L
I
M
M
ST
QI
SWQL
---
T
L
F
AL
L
P
M
PV
M
AI
MIKRNG
D
ALHE
RF
K
LAQ
A
AFS
S
L
ND
RTQE
S
LTS
I
--
-
-RM
I
KA
FG
-----------
LED
R
QSALFAADAEDTGKKN
M
R
VA
R
I
D
A
-
RF
DP
T
I
Y
I
AI
GM
A
N
--
LL
A
I
G
G
G
S
WMV
V
Q
GSLT
L
G
Q
LT
S
F
M
M
YLG
L
M
IW
P
M
LA
L
A
WM
FNIVERG
S
A
AY
S
R
IR
T
M
LAEA
P
V
V
I
DG
S
D
KV
PE
----
----
-
--G
RG
E
L
DV
N
IR
--
Q
FTYP
QT
D
H
PAL
E
N
V
N
F
A
L
K
P
G
QM
V
GIC
G
P
TGSGKSTL
L
SLI
Q
R
H
F
D
V
S
EG
D
IR
F
HD
I
PL
TK
L
Q
L
D
S
W
R
SR
L
A
V
VSQ
T
P
F
LF
S
DTVANNIALG
-
CPNA
T
Q
Q
E
IE
H
V
AR
L
A
SVH
D
D
I
LR
L
PQ
G
Y
DT
E
V
GE
R
GV
M
LSGGQKQRI
S
IARALL
VNAE
ILILD
D
A
L
SA
V
D
GR
TE
H
Q
I
L
H
N
L
RQWG
Q
G
RT
V
I
IS
AHRLS
AL
T
E
A
S
EI
I
V
M
QH
G
H
I
AQ
RG
N
H
DE
L
A
QQS
G
W
Y
R
D
MY
R
Y
Q
QL
EAA
L
DDAPE
I
R
E
E
fig|749546.3.peg.3558
Escherichia coli MS 185-1 (1-586/590)
MR
L
F
A
QL
S
W
Y
FRR
E
------
W
--------
R
R
YLG
A
VALL
VI
--
-
--IA
ML
Q
L
VP
P
KVVGIVV
DG
VTEQHF
T
TGQ
I
L
M
W
I
A
TM
V
L
--
--
----
-
--
IA
VVV
Y
LLR
Y
VW
R
V
L
LFG
A
SYQ
LA
VE
LR
E
D
YYRQLS
RQ
H
P
E
F
YL
R
H
R
TG
D
L
M
A
R
A
TND
V
D
-------
R
VV
FAAGEGVL
T
L
V
-
-D
S
LV
M
G
CAV
L
I
M
M
ST
QI
SWQL
---
T
L
F
AL
L
P
M
PV
M
AI
MIKRNG
D
ALHE
RF
K
LAQ
A
AFS
S
L
ND
RTQE
S
LTS
I
--
-
-RM
I
KA
FG
-----------
LED
R
QSALFAADAEDTGKKN
M
R
VA
R
I
D
A
-
RF
DP
T
I
Y
I
AI
GM
A
N
--
LL
A
I
G
G
G
S
WMV
V
Q
GSLT
L
G
Q
LT
S
F
M
M
YLG
L
M
IW
P
M
LA
L
A
WM
FNIVERG
S
A
AY
S
R
IR
T
M
LAEA
P
V
V
I
DG
S
D
KV
PE
----
----
-
--G
RG
E
L
DV
N
IR
--
Q
FTYP
QT
D
H
PAL
E
N
V
N
F
A
L
K
P
G
QM
V
GIC
G
P
TGSGKSTL
L
SLI
Q
R
H
F
D
V
S
EG
D
IR
F
HD
I
PL
TK
L
Q
L
D
S
W
R
SR
L
A
V
VSQ
T
P
F
LF
S
DTVANNIALG
-
CPNA
T
Q
Q
E
IE
H
V
AR
L
A
SVH
D
D
I
LR
L
PQ
G
Y
DT
E
V
GE
R
GV
M
LSGGQKQRI
S
IARALL
VNAE
ILILD
D
A
L
SA
V
D
GR
TE
H
Q
I
L
H
N
L
RQWG
Q
G
RT
V
I
IS
AHRLS
AL
T
E
A
S
EI
I
V
M
QH
G
H
I
AQ
RG
N
H
DE
L
A
QQS
G
W
Y
R
D
MY
R
Y
Q
QL
EAA
L
DDAPE
I
R
E
E
fig|749550.3.peg.4729
Escherichia coli MS 200-1 (1-586/590)
MR
L
F
A
QL
S
W
Y
FRR
E
------
W
--------
R
R
YLG
A
VALL
VI
--
-
--IA
ML
Q
L
VP
P
KVVGIVV
DG
VTEQHF
T
TGQ
I
L
M
W
I
A
TM
V
L
--
--
----
-
--
IA
VVV
Y
LLR
Y
VW
R
V
L
LFG
A
SYQ
LA
VE
LR
E
D
YYRQLS
RQ
H
P
E
F
YL
R
H
R
TG
D
L
M
A
R
A
TND
V
D
-------
R
VV
FAAGEGVL
T
L
V
-
-D
S
LV
M
G
CAV
L
I
M
M
ST
QI
SWQL
---
T
L
F
AL
L
P
M
PV
M
AI
MIKRNG
D
ALHE
RF
K
LAQ
A
AFS
S
L
ND
RTQE
S
LTS
I
--
-
-RM
I
KA
FG
-----------
LED
R
QSALFAADAEDTGKKN
M
R
VA
R
I
D
A
-
RF
DP
T
I
Y
I
AI
GM
A
N
--
LL
A
I
G
G
G
S
WVG
V
Q
GSLT
L
G
Q
LT
S
F
M
M
YLG
L
M
IW
P
M
LA
L
A
WM
FNIVERG
S
A
AY
S
R
IR
T
M
LAEA
P
V
V
I
DG
S
D
KV
PE
----
----
-
--G
RG
E
L
DV
N
IR
--
Q
FTYP
QT
D
H
PAL
E
N
V
N
F
A
L
K
P
G
QM
V
GIC
G
P
TGSGKSTL
L
SLI
Q
R
H
F
D
V
S
EG
D
IR
F
HD
I
PL
TK
L
Q
L
D
S
W
R
SR
L
A
V
VSQ
T
P
F
LF
S
DTVANNIALG
-
CPNA
T
Q
Q
E
IE
H
V
AR
L
A
SVH
D
D
I
LR
L
PQ
G
Y
DT
E
V
GE
R
GV
M
LSGGQKQRI
S
IARALL
VNAE
ILILD
D
A
L
SA
V
D
GR
TE
H
Q
I
L
H
N
L
RQWG
Q
G
RT
V
I
IS
AHRLS
AL
T
E
A
S
EI
I
V
M
QH
G
H
I
AQ
RG
N
H
DE
L
A
QQS
G
W
Y
R
D
MY
R
Y
Q
QL
EAA
L
DDAPE
I
R
E
E
fig|749528.3.peg.3611
Escherichia coli MS 45-1 (1-586/590)
MR
L
F
A
QL
S
W
Y
FRR
E
------
W
--------
R
R
YLG
A
VALL
VI
--
-
--IA
ML
Q
L
VP
P
KVVGIVV
DG
VTEQHF
T
TGQ
I
L
M
W
I
A
TM
V
L
--
--
----
-
--
IA
VVV
Y
LLR
Y
VW
R
V
L
LFG
A
SYQ
LA
VE
LR
E
D
YYRQLS
RQ
H
P
E
F
YL
R
H
R
TG
D
L
M
A
R
A
TND
V
D
-------
R
VV
FAAGEGVL
T
L
V
-
-D
S
LV
M
G
CAV
L
I
M
M
ST
QI
SWQL
---
T
L
F
AL
L
P
M
PV
M
AI
MIKRNG
D
ALHE
RF
K
LAQ
A
AFS
S
L
ND
RTQE
S
LTS
I
--
-
-RM
I
KA
FG
-----------
LED
R
QSALFAADAEDTGKKN
M
R
VA
R
I
D
A
-
RF
DP
T
I
Y
I
AI
GM
A
N
--
LL
A
I
G
G
G
S
WMV
V
Q
GSLT
L
G
Q
LT
S
F
M
M
YLG
L
M
IW
P
M
LA
L
A
WM
FNIVERG
S
A
AY
S
R
IR
T
M
LAEA
P
V
V
I
DG
S
D
KV
PE
----
----
-
--G
RG
E
L
DV
N
IR
--
Q
FTYP
QT
D
H
PAL
E
N
V
N
F
A
L
K
P
G
QM
V
GIC
G
P
TGSGKSTL
L
SLI
Q
R
H
F
D
V
S
EG
D
IR
F
HD
I
PL
TK
L
Q
L
D
S
W
R
SR
L
A
V
VSQ
T
P
F
LF
S
DTVANNIALG
-
CPNA
T
Q
Q
E
IE
H
V
AR
L
A
SVH
D
D
I
LR
L
PQ
G
Y
DT
E
V
GE
R
GV
M
LSGGQKQRI
S
IARALL
VNAE
ILILD
D
A
L
SA
V
D
GR
TE
H
Q
I
L
H
N
L
RQWG
Q
G
RT
V
I
IS
AHRLS
AL
T
E
A
S
EI
I
V
M
QH
G
H
I
AQ
RG
N
H
DE
L
A
QQS
G
W
Y
R
D
MY
R
Y
Q
QL
EAA
L
DDAPE
I
R
E
E
fig|685038.3.peg.424
Escherichia coli O83:H1 str. NRG 857C (1-586/590)
MR
L
F
A
QL
S
W
Y
FRR
E
------
W
--------
R
R
YLG
A
VALL
VI
--
-
--IA
ML
Q
L
VP
P
KVVGIVV
DG
VTEQHF
T
TGQ
I
L
M
W
I
A
TM
V
L
--
--
----
-
--
IA
VVV
Y
LLR
Y
VW
R
V
L
LFG
A
SYQ
LA
VE
LR
E
D
YYRQLS
RQ
H
P
E
F
YL
R
H
R
TG
D
L
M
A
R
A
TND
V
D
-------
R
VV
FAAGEGVL
T
L
V
-
-D
S
LV
M
G
CAV
L
I
M
M
ST
QI
SWQL
---
T
L
F
AL
L
P
M
PV
M
AI
MIKRNG
D
ALHE
RF
K
LAQ
A
AFS
S
L
ND
RTQE
S
LTS
I
--
-
-RM
I
KA
FG
-----------
LED
R
QSALFAADAEDTGKKN
M
R
VA
R
I
D
A
-
RF
DP
T
I
Y
I
AI
GM
A
N
--
LL
A
I
G
G
G
S
WMV
V
Q
GSLT
L
G
Q
LT
S
F
M
M
YLG
L
M
IW
P
M
LA
L
A
WM
FNIVERG
S
A
AY
S
R
IR
T
M
LAEA
P
V
V
I
DG
S
D
KV
PE
----
----
-
--G
RG
E
L
DV
N
IR
--
Q
FTYP
QT
D
H
PAL
E
N
V
N
F
A
L
K
P
G
QM
V
GIC
G
P
TGSGKSTL
L
SLI
Q
R
H
F
D
V
S
EG
D
IR
F
HD
I
PL
TK
L
Q
L
D
S
W
R
SR
L
A
V
VSQ
T
P
F
LF
S
DTVANNIALG
-
CPNA
T
Q
Q
E
IE
H
V
AR
L
A
SVH
D
D
I
LR
L
PQ
G
Y
DT
E
V
GE
R
GV
M
LSGGQKQRI
S
IARALL
VNAE
ILILD
D
A
L
SA
V
D
GR
TE
H
Q
I
L
H
N
L
RQWG
Q
G
RT
V
I
IS
AHRLS
AL
T
E
A
S
EI
I
V
M
QH
G
H
I
AQ
RG
N
H
DE
L
A
QQS
G
W
Y
R
D
MY
R
Y
Q
QL
EAA
L
DDAPE
I
R
E
E
fig|585396.4.peg.497
Escherichia coli O111:H- str. 11128 (1-586/590)
MR
L
F
A
QL
S
W
Y
FRR
E
------
W
--------
R
R
YLG
A
VALL
VI
--
-
--IA
ML
Q
L
VP
P
KVVGIVV
DG
VTEQHF
T
TGL
I
L
M
W
I
A
TM
V
L
--
--
----
-
--
IA
VVV
Y
LLR
Y
VW
R
V
L
LFG
A
SYQ
LA
VE
LR
E
D
YYRQLS
RQ
H
P
E
F
YL
R
H
R
TG
D
L
M
A
R
A
TND
V
D
-------
R
VV
FAAGEGVL
T
L
V
-
-D
S
LV
M
G
CAV
L
I
M
M
ST
QI
SWQL
---
T
L
F
AL
L
P
M
PV
M
AI
MIKRNG
D
ALHE
RF
K
LAQ
A
AFS
S
L
ND
RTQE
S
LTS
I
--
-
-RM
I
KA
FG
-----------
LED
R
QSALFAADAEDTGKKN
M
R
VA
R
I
D
A
-
RF
DP
T
I
Y
I
AI
GM
A
N
--
LL
A
I
G
G
G
S
WMV
V
Q
GSLT
L
G
Q
LT
S
F
M
M
YLG
L
M
IW
P
M
LA
L
A
WM
FNIVERG
S
A
AY
S
R
IR
A
M
LAEA
P
V
V
N
DG
S
E
PV
PE
----
----
-
--G
RG
E
L
DV
N
IH
--
Q
FTYP
QT
D
H
R
AL
E
N
V
N
F
A
L
K
P
G
QM
LGIC
G
P
TGSGKSTL
L
SLI
Q
R
H
F
D
V
S
EG
D
IR
F
HD
I
PL
TK
L
Q
L
D
S
W
R
SR
L
A
V
VSQ
T
P
F
LF
S
DTVA
S
NIALG
-
CPNA
T
Q
Q
E
IE
H
V
AR
L
A
SVH
D
D
I
LR
L
PQ
G
Y
DT
E
V
GE
R
GV
M
LSGGQKQRI
S
IARALL
VNAE
ILILD
D
A
L
SA
V
D
GR
TE
H
Q
I
L
H
N
L
RQWG
Q
G
RT
V
I
IS
AHRLS
AL
T
E
A
S
EI
I
V
M
QH
G
H
I
AQ
RG
N
H
DE
L
A
QQS
G
W
Y
R
D
MY
R
Y
Q
QL
EAA
L
DDAPE
I
R
E
E
fig|405955.13.peg.451
Escherichia coli APEC O1 (1-586/590)
MR
L
F
A
QL
S
W
Y
FRR
E
------
W
--------
R
R
YLG
A
VALL
VI
--
-
--IA
ML
Q
L
VP
P
KVVGIVV
DG
VTEQHF
T
TGQ
I
L
M
W
I
A
TM
V
L
--
--
----
-
--
IA
VVV
Y
LLR
Y
VW
R
V
L
LFG
A
SYQ
LA
VE
LR
E
D
YYRQLS
RQ
H
P
E
F
YL
R
H
R
TG
D
L
M
A
R
A
TND
V
D
-------
R
VV
FAAGEGVL
T
L
V
-
-D
S
LV
M
G
CAV
L
I
M
M
ST
QI
SWQL
---
T
L
F
AL
L
P
M
PV
M
AI
MIKRNS
D
ALHE
RF
K
LAQ
A
AFS
S
L
ND
RTQE
S
LTS
I
--
-
-RM
I
KA
FG
-----------
LED
R
QSALFAADAEDTGKKN
M
R
VA
R
I
D
A
-
RF
DP
T
I
Y
I
AI
GM
A
N
--
LL
A
I
G
G
G
S
WMV
V
Q
GSLT
L
G
Q
LT
S
F
I
M
YLG
L
M
IW
P
M
LA
L
A
WM
FNIVERG
S
A
AY
S
R
IR
T
M
LAEA
P
V
V
I
DG
S
D
KV
PE
----
----
-
--G
RG
E
L
DV
N
IR
--
Q
FTYP
QT
D
H
PAL
E
N
V
N
F
A
L
K
P
G
QM
V
GIC
G
P
TGSGKSTL
L
SLI
Q
R
H
F
D
V
S
EG
D
IR
F
HD
I
PL
TK
L
Q
L
D
S
W
R
SR
L
A
V
VSQ
T
P
F
LF
S
DTVANNIALG
-
CPNA
I
Q
Q
E
IE
H
V
AR
L
A
SVH
D
D
I
LR
L
PQ
G
Y
DT
E
V
GE
R
GV
M
LSGGQKQRI
S
IARALL
VNAE
ILILD
D
A
L
SA
V
D
GR
TE
H
Q
I
L
H
N
L
RQWG
Q
G
RT
V
I
IS
AHRLS
AL
T
E
A
S
EI
I
V
M
QH
G
H
I
G
Q
RG
N
H
DV
L
V
QQS
G
W
Y
R
D
MY
R
Y
Q
QL
EAA
L
DDAPE
I
R
E
E
fig|405955.9.peg.369
Escherichia coli APEC O1 (1-586/590)
MR
L
F
A
QL
S
W
Y
FRR
E
------
W
--------
R
R
YLG
A
VALL
VI
--
-
--IA
ML
Q
L
VP
P
KVVGIVV
DG
VTEQHF
T
TGQ
I
L
M
W
I
A
TM
V
L
--
--
----
-
--
IA
VVV
Y
LLR
Y
VW
R
V
L
LFG
A
SYQ
LA
VE
LR
E
D
YYRQLS
RQ
H
P
E
F
YL
R
H
R
TG
D
L
M
A
R
A
TND
V
D
-------
R
VV
FAAGEGVL
T
L
V
-
-D
S
LV
M
G
CAV
L
I
M
M
ST
QI
SWQL
---
T
L
F
AL
L
P
M
PV
M
AI
MIKRNS
D
ALHE
RF
K
LAQ
A
AFS
S
L
ND
RTQE
S
LTS
I
--
-
-RM
I
KA
FG
-----------
LED
R
QSALFAADAEDTGKKN
M
R
VA
R
I
D
A
-
RF
DP
T
I
Y
I
AI
GM
A
N
--
LL
A
I
G
G
G
S
WMV
V
Q
GSLT
L
G
Q
LT
S
F
I
M
YLG
L
M
IW
P
M
LA
L
A
WM
FNIVERG
S
A
AY
S
R
IR
T
M
LAEA
P
V
V
I
DG
S
D
KV
PE
----
----
-
--G
RG
E
L
DV
N
IR
--
Q
FTYP
QT
D
H
PAL
E
N
V
N
F
A
L
K
P
G
QM
V
GIC
G
P
TGSGKSTL
L
SLI
Q
R
H
F
D
V
S
EG
D
IR
F
HD
I
PL
TK
L
Q
L
D
S
W
R
SR
L
A
V
VSQ
T
P
F
LF
S
DTVANNIALG
-
CPNA
I
Q
Q
E
IE
H
V
AR
L
A
SVH
D
D
I
LR
L
PQ
G
Y
DT
E
V
GE
R
GV
M
LSGGQKQRI
S
IARALL
VNAE
ILILD
D
A
L
SA
V
D
GR
TE
H
Q
I
L
H
N
L
RQWG
Q
G
RT
V
I
IS
AHRLS
AL
T
E
A
S
EI
I
V
M
QH
G
H
I
G
Q
RG
N
H
DV
L
V
QQS
G
W
Y
R
D
MY
R
Y
Q
QL
EAA
L
DDAPE
I
R
E
E
fig|344601.3.peg.3356
Escherichia coli B171 (1-586/590)
MR
L
F
A
QL
S
W
Y
FRR
E
------
W
--------
R
R
YLG
A
VALL
VI
--
-
--IA
ML
Q
L
VP
P
KVVGIVV
DG
VTEQHF
T
TGQ
I
L
M
W
I
A
TM
V
L
--
--
----
-
--
IA
VVV
Y
LLR
Y
VW
R
V
L
LFG
A
SYQ
LA
VE
LR
E
D
YYRQLS
RQ
H
P
E
F
YL
R
H
R
TG
D
L
M
A
R
A
TND
V
D
-------
R
VV
FAAGEGVL
T
L
V
-
-D
S
LV
M
G
CAV
L
I
M
M
ST
QI
SWQL
---
T
L
F
AL
L
P
M
PV
M
AI
MIKRNG
D
ALHE
RF
K
LAQ
A
AFS
S
L
ND
RTQE
S
LTS
I
--
-
-RM
I
KA
FG
-----------
LED
R
QSALFAADAEDTGKKN
M
R
VA
R
I
D
A
-
RF
DP
T
I
Y
I
AI
GM
A
N
--
LL
A
I
G
G
G
S
WMV
A
Q
GSLT
L
G
Q
LT
S
F
M
M
YLG
L
M
IW
P
M
LA
L
A
WM
FNIVERG
S
A
AY
S
R
IR
A
M
LAEA
P
V
V
N
DG
S
E
PV
PE
----
----
-
--G
RG
E
L
DV
N
IH
--
Q
FTYP
QT
D
H
PAL
E
N
V
N
F
A
L
K
P
G
QM
LGIC
G
P
TGSGKSTL
L
SLI
Q
R
H
F
D
V
S
EG
D
IR
F
HD
I
PL
TK
L
Q
L
D
S
W
R
SR
L
A
V
VSQ
T
P
F
LF
S
DTVANNIALG
-
CPNA
T
Q
Q
E
IE
H
V
AR
L
A
SVH
D
D
I
LR
L
PQ
G
Y
DT
E
V
GE
R
GV
M
LSGGQKQRI
S
IARALL
VNAE
ILILD
D
A
L
SA
V
D
GR
TE
H
Q
I
L
H
N
L
RQWG
Q
G
RT
V
I
IS
AHRLS
AL
T
E
A
S
EI
I
V
M
QH
G
H
I
AQ
RG
N
H
DE
L
A
QQS
G
W
Y
R
D
MY
R
Y
Q
QL
EAA
L
DDAPE
I
R
E
E
fig|344601.5.peg.3511
Escherichia coli B171 (1-586/590)
MR
L
F
A
QL
S
W
Y
FRR
E
------
W
--------
R
R
YLG
A
VALL
VI
--
-
--IA
ML
Q
L
VP
P
KVVGIVV
DG
VTEQHF
T
TGQ
I
L
M
W
I
A
TM
V
L
--
--
----
-
--
IA
VVV
Y
LLR
Y
VW
R
V
L
LFG
A
SYQ
LA
VE
LR
E
D
YYRQLS
RQ
H
P
E
F
YL
R
H
R
TG
D
L
M
A
R
A
TND
V
D
-------
R
VV
FAAGEGVL
T
L
V
-
-D
S
LV
M
G
CAV
L
I
M
M
ST
QI
SWQL
---
T
L
F
AL
L
P
M
PV
M
AI
MIKRNG
D
ALHE
RF
K
LAQ
A
AFS
S
L
ND
RTQE
S
LTS
I
--
-
-RM
I
KA
FG
-----------
LED
R
QSALFAADAEDTGKKN
M
R
VA
R
I
D
A
-
RF
DP
T
I
Y
I
AI
GM
A
N
--
LL
A
I
G
G
G
S
WMV
A
Q
GSLT
L
G
Q
LT
S
F
M
M
YLG
L
M
IW
P
M
LA
L
A
WM
FNIVERG
S
A
AY
S
R
IR
A
M
LAEA
P
V
V
N
DG
S
E
PV
PE
----
----
-
--G
RG
E
L
DV
N
IH
--
Q
FTYP
QT
D
H
PAL
E
N
V
N
F
A
L
K
P
G
QM
LGIC
G
P
TGSGKSTL
L
SLI
Q
R
H
F
D
V
S
EG
D
IR
F
HD
I
PL
TK
L
Q
L
D
S
W
R
SR
L
A
V
VSQ
T
P
F
LF
S
DTVANNIALG
-
CPNA
T
Q
Q
E
IE
H
V
AR
L
A
SVH
D
D
I
LR
L
PQ
G
Y
DT
E
V
GE
R
GV
M
LSGGQKQRI
S
IARALL
VNAE
ILILD
D
A
L
SA
V
D
GR
TE
H
Q
I
L
H
N
L
RQWG
Q
G
RT
V
I
IS
AHRLS
AL
T
E
A
S
EI
I
V
M
QH
G
H
I
AQ
RG
N
H
DE
L
A
QQS
G
W
Y
R
D
MY
R
Y
Q
QL
EAA
L
DDAPE
I
R
E
E
fig|340186.3.peg.889
Escherichia coli E110019 (1-586/590)
MR
L
F
A
QL
S
W
Y
FRR
E
------
W
--------
R
R
YLG
A
VALL
VI
--
-
--IA
ML
Q
L
VP
P
KVVGIVV
DG
VTEQHF
T
TGQ
I
L
M
W
I
A
TM
V
L
--
--
----
-
--
IA
VVV
Y
LLR
Y
VW
R
V
L
LFG
A
SYQ
LA
VE
LR
E
D
YYRQLS
RQ
H
P
E
F
YL
R
H
R
TG
D
L
M
A
R
A
TND
V
D
-------
R
VV
FAAGEGVL
T
L
V
-
-D
S
LV
M
G
CAV
L
I
M
M
ST
QI
SWQL
---
T
L
F
AL
L
P
M
PV
M
AI
MIKRNG
D
ALHE
RF
K
LAQ
A
AFS
S
L
ND
RTQE
S
LTS
I
--
-
-RM
I
KA
FG
-----------
LED
R
QSALFAADAEDTGKKN
M
R
VA
R
I
D
A
-
RF
DP
T
I
Y
I
AI
GM
A
N
--
LL
A
I
G
G
G
S
WMV
A
Q
GSLT
L
G
Q
LT
S
F
M
M
YLG
L
M
IW
P
M
LA
L
A
WM
FNIVERG
S
A
AY
S
R
IR
A
M
LAEA
P
V
V
N
DG
S
E
PV
PE
----
----
-
--G
RG
E
L
DV
N
IH
--
Q
FTYP
QT
D
H
PAL
E
N
V
N
F
A
L
K
P
G
QM
LGIC
G
P
TGSGKSTL
L
SLI
Q
R
H
F
D
V
S
EG
D
IR
F
HD
I
PL
TK
L
Q
L
D
S
W
R
SR
L
A
V
VSQ
T
P
F
LF
S
DTVANNIALG
-
CPNA
T
Q
Q
E
IE
H
V
AR
L
A
SVH
D
D
I
LR
L
PQ
G
Y
DT
E
V
GE
R
GV
M
LSGGQKQRI
S
IARALL
VNAE
ILILD
D
A
L
SA
V
D
GR
TE
H
Q
I
L
H
N
L
RQWG
Q
G
RT
V
I
IS
AHRLS
AL
T
E
A
S
EI
I
V
M
QH
G
H
I
AQ
RG
N
H
DE
L
A
QQS
G
W
Y
R
D
MY
R
Y
Q
QL
EAA
L
DDAPE
I
R
E
E
fig|340186.5.peg.929
Escherichia coli E110019 (1-586/590)
MR
L
F
A
QL
S
W
Y
FRR
E
------
W
--------
R
R
YLG
A
VALL
VI
--
-
--IA
ML
Q
L
VP
P
KVVGIVV
DG
VTEQHF
T
TGQ
I
L
M
W
I
A
TM
V
L
--
--
----
-
--
IA
VVV
Y
LLR
Y
VW
R
V
L
LFG
A
SYQ
LA
VE
LR
E
D
YYRQLS
RQ
H
P
E
F
YL
R
H
R
TG
D
L
M
A
R
A
TND
V
D
-------
R
VV
FAAGEGVL
T
L
V
-
-D
S
LV
M
G
CAV
L
I
M
M
ST
QI
SWQL
---
T
L
F
AL
L
P
M
PV
M
AI
MIKRNG
D
ALHE
RF
K
LAQ
A
AFS
S
L
ND
RTQE
S
LTS
I
--
-
-RM
I
KA
FG
-----------
LED
R
QSALFAADAEDTGKKN
M
R
VA
R
I
D
A
-
RF
DP
T
I
Y
I
AI
GM
A
N
--
LL
A
I
G
G
G
S
WMV
A
Q
GSLT
L
G
Q
LT
S
F
M
M
YLG
L
M
IW
P
M
LA
L
A
WM
FNIVERG
S
A
AY
S
R
IR
A
M
LAEA
P
V
V
N
DG
S
E
PV
PE
----
----
-
--G
RG
E
L
DV
N
IH
--
Q
FTYP
QT
D
H
PAL
E
N
V
N
F
A
L
K
P
G
QM
LGIC
G
P
TGSGKSTL
L
SLI
Q
R
H
F
D
V
S
EG
D
IR
F
HD
I
PL
TK
L
Q
L
D
S
W
R
SR
L
A
V
VSQ
T
P
F
LF
S
DTVANNIALG
-
CPNA
T
Q
Q
E
IE
H
V
AR
L
A
SVH
D
D
I
LR
L
PQ
G
Y
DT
E
V
GE
R
GV
M
LSGGQKQRI
S
IARALL
VNAE
ILILD
D
A
L
SA
V
D
GR
TE
H
Q
I
L
H
N
L
RQWG
Q
G
RT
V
I
IS
AHRLS
AL
T
E
A
S
EI
I
V
M
QH
G
H
I
AQ
RG
N
H
DE
L
A
QQS
G
W
Y
R
D
MY
R
Y
Q
QL
EAA
L
DDAPE
I
R
E
E
fig|340185.3.peg.2565
Escherichia coli E22 (1-586/590)
MR
L
F
A
QL
S
W
Y
FRR
E
------
W
--------
R
R
YLG
A
VALL
VI
--
-
--IA
ML
Q
L
VP
P
KVVGIVV
DG
VTEQHF
T
TGQ
I
L
M
W
I
A
TM
V
L
--
--
----
-
--
IA
VVV
Y
LLR
Y
VW
R
V
L
LFG
A
SYQ
LA
VE
LR
E
D
YYRQLS
RQ
H
P
E
F
YL
R
H
R
TG
D
L
M
A
R
A
TND
V
D
-------
R
VV
FAAGEGVL
T
L
V
-
-D
S
LV
M
G
CAV
L
I
M
M
ST
QI
SWQL
---
T
L
F
AL
L
P
M
PV
M
AI
MIKRNG
D
ALHE
RF
K
LAQ
A
AFS
S
L
ND
RTQE
S
LTS
I
--
-
-RM
I
KA
FG
-----------
LED
R
QSALFAADAEDTGKKN
M
R
VA
R
I
D
A
-
RF
DP
T
I
Y
I
AI
GM
A
N
--
LL
A
I
G
G
G
S
WMV
A
Q
GSLT
L
G
Q
LT
S
F
M
M
YLG
L
M
IW
P
M
LA
L
A
WM
FNIVERG
S
A
AY
S
R
IR
A
M
LAEA
P
V
V
N
DG
S
E
PV
PE
----
----
-
--G
RG
E
L
DV
N
IH
--
Q
FTYP
QT
D
H
PAL
E
N
V
N
F
A
L
K
P
G
QM
LGIC
G
P
TGSGKSTL
L
SLI
Q
R
H
F
D
V
S
EG
D
IR
F
HD
I
PL
TK
L
Q
L
D
S
W
R
SR
L
A
V
VSQ
T
P
F
LF
S
DTVANNIALG
-
CPNA
T
Q
Q
E
IE
H
V
AR
L
A
SVH
D
D
I
LR
L
PQ
G
Y
DT
E
V
GE
R
GV
M
LSGGQKQRI
S
IARALL
VNAE
ILILD
D
A
L
SA
V
D
GR
TE
H
Q
I
L
H
N
L
RQWG
Q
G
RT
V
I
IS
AHRLS
AL
T
E
A
S
EI
I
V
M
QH
G
H
I
AQ
RG
N
H
DE
L
A
QQS
G
W
Y
R
D
MY
R
Y
Q
QL
EAA
L
DDAPE
I
R
E
E
fig|340185.4.peg.2707
Escherichia coli E22 (1-586/590)
MR
L
F
A
QL
S
W
Y
FRR
E
------
W
--------
R
R
YLG
A
VALL
VI
--
-
--IA
ML
Q
L
VP
P
KVVGIVV
DG
VTEQHF
T
TGQ
I
L
M
W
I
A
TM
V
L
--
--
----
-
--
IA
VVV
Y
LLR
Y
VW
R
V
L
LFG
A
SYQ
LA
VE
LR
E
D
YYRQLS
RQ
H
P
E
F
YL
R
H
R
TG
D
L
M
A
R
A
TND
V
D
-------
R
VV
FAAGEGVL
T
L
V
-
-D
S
LV
M
G
CAV
L
I
M
M
ST
QI
SWQL
---
T
L
F
AL
L
P
M
PV
M
AI
MIKRNG
D
ALHE
RF
K
LAQ
A
AFS
S
L
ND
RTQE
S
LTS
I
--
-
-RM
I
KA
FG
-----------
LED
R
QSALFAADAEDTGKKN
M
R
VA
R
I
D
A
-
RF
DP
T
I
Y
I
AI
GM
A
N
--
LL
A
I
G
G
G
S
WMV
A
Q
GSLT
L
G
Q
LT
S
F
M
M
YLG
L
M
IW
P
M
LA
L
A
WM
FNIVERG
S
A
AY
S
R
IR
A
M
LAEA
P
V
V
N
DG
S
E
PV
PE
----
----
-
--G
RG
E
L
DV
N
IH
--
Q
FTYP
QT
D
H
PAL
E
N
V
N
F
A
L
K
P
G
QM
LGIC
G
P
TGSGKSTL
L
SLI
Q
R
H
F
D
V
S
EG
D
IR
F
HD
I
PL
TK
L
Q
L
D
S
W
R
SR
L
A
V
VSQ
T
P
F
LF
S
DTVANNIALG
-
CPNA
T
Q
Q
E
IE
H
V
AR
L
A
SVH
D
D
I
LR
L
PQ
G
Y
DT
E
V
GE
R
GV
M
LSGGQKQRI
S
IARALL
VNAE
ILILD
D
A
L
SA
V
D
GR
TE
H
Q
I
L
H
N
L
RQWG
Q
G
RT
V
I
IS
AHRLS
AL
T
E
A
S
EI
I
V
M
QH
G
H
I
AQ
RG
N
H
DE
L
A
QQS
G
W
Y
R
D
MY
R
Y
Q
QL
EAA
L
DDAPE
I
R
E
E
fig|562.375.peg.3726
Escherichia coli EC4100B (1-586/590)
MR
L
F
A
QL
S
W
Y
FRR
E
------
W
--------
R
R
YLG
A
VALL
VI
--
-
--IA
ML
Q
L
VP
P
KVVGIVV
DG
VTEQHF
T
TGQ
I
L
M
W
I
A
TM
V
L
--
--
----
-
--
IA
VVV
Y
LLR
Y
VW
R
V
L
LFG
A
SYQ
LA
VE
LR
E
D
YYRQLS
RQ
H
P
E
F
YL
R
H
R
TG
D
L
M
A
R
A
TND
V
D
-------
R
VV
FAAGEGVL
T
L
V
-
-D
S
LV
M
G
CAV
L
I
M
M
ST
QI
SWQL
---
T
L
F
AL
L
P
M
PV
M
AI
MIKRNG
D
ALHE
RF
K
LAQ
A
AFS
S
L
ND
RTQE
S
LTS
I
--
-
-RM
I
KA
FG
-----------
LED
R
QSALFAADAEDTGKKN
M
R
VA
R
I
D
A
-
RF
DP
T
I
Y
I
AI
GM
A
N
--
LL
A
I
G
G
G
S
WMV
A
Q
GSLT
L
G
Q
LT
S
F
M
M
YLG
L
M
IW
P
M
LA
L
A
WM
FNIVERG
S
A
AY
S
R
IR
A
M
LAEA
P
V
V
N
DG
S
E
PV
PE
----
----
-
--G
RG
E
L
DV
N
IH
--
Q
FTYP
QT
D
H
PAL
E
N
V
N
F
A
L
K
P
G
QM
LGIC
G
P
TGSGKSTL
L
SLI
Q
R
H
F
D
V
S
EG
D
IR
F
HD
I
PL
TK
L
Q
L
D
S
W
R
SR
L
A
V
VSQ
T
P
F
LF
S
DTVANNIALG
-
CPNA
T
Q
Q
E
IE
H
V
AR
L
A
SVH
D
D
I
LR
L
PQ
G
Y
DT
E
V
GE
R
GV
M
LSGGQKQRI
S
IARALL
VNAE
ILILD
D
A
L
SA
V
D
GR
TE
H
Q
I
L
H
N
L
RQWG
Q
G
RT
V
I
IS
AHRLS
AL
T
E
A
S
EI
I
V
M
QH
G
H
I
AQ
RG
N
H
DE
L
A
QQS
G
W
Y
R
D
MY
R
Y
Q
QL
EAA
L
DDAPE
I
R
E
E
fig|679207.4.peg.3177
Escherichia coli MS 107-1 (1-586/590)
MR
L
F
A
QL
S
W
Y
FRR
E
------
W
--------
R
R
YLG
A
VALL
VI
--
-
--IA
ML
Q
L
VP
P
KVVGIVV
DG
VTEQHF
T
TGQ
I
L
M
W
I
A
TM
V
L
--
--
----
-
--
IA
VVV
Y
LLR
Y
VW
R
V
L
LFG
A
SYQ
LA
VE
LR
E
D
YYRQLS
RQ
H
P
E
F
YL
R
H
R
TG
D
L
M
A
R
A
TND
V
D
-------
R
VV
FAAGEGVL
T
L
V
-
-D
S
LV
M
G
CAV
L
I
M
M
ST
QI
SWQL
---
T
L
F
AL
L
P
M
PV
M
AI
MIKRNG
D
ALHE
RF
K
LAQ
A
AFS
S
L
ND
RTQE
S
LTS
I
--
-
-RM
I
KA
FG
-----------
LED
R
QSALFAADAEDTGKKN
M
R
VA
R
I
D
A
-
RF
DP
T
I
Y
I
AI
GM
A
N
--
LL
A
I
G
G
G
S
WMV
A
Q
GSLT
L
G
Q
LT
S
F
M
M
YLG
L
M
IW
P
M
LA
L
A
WM
FNIVERG
S
A
AY
S
R
IR
A
M
LAEA
P
V
V
N
DG
S
E
PV
PE
----
----
-
--G
RG
E
L
DV
N
IH
--
Q
FTYP
QT
D
H
PAL
E
N
V
N
F
A
L
K
P
G
QM
LGIC
G
P
TGSGKSTL
L
SLI
Q
R
H
F
D
V
S
EG
D
IR
F
HD
I
PL
TK
L
Q
L
D
S
W
R
SR
L
A
V
VSQ
T
P
F
LF
S
DTVANNIALG
-
CPNA
T
Q
Q
E
IE
H
V
AR
L
A
SVH
D
D
I
LR
L
PQ
G
Y
DT
E
V
GE
R
GV
M
LSGGQKQRI
S
IARALL
VNAE
ILILD
D
A
L
SA
V
D
GR
TE
H
Q
I
L
H
N
L
RQWG
Q
G
RT
V
I
IS
AHRLS
AL
T
E
A
S
EI
I
V
M
QH
G
H
I
AQ
RG
N
H
DE
L
A
QQS
G
W
Y
R
D
MY
R
Y
Q
QL
EAA
L
DDAPE
I
R
E
E
fig|749545.3.peg.2224
Escherichia coli MS 182-1 (1-586/590)
MR
L
F
A
QL
S
W
Y
FRR
E
------
W
--------
R
R
YLG
A
VALL
VI
--
-
--IA
ML
Q
L
VP
P
KVVGIVV
DG
VTEQHF
T
TGQ
I
L
M
W
I
A
TM
V
L
--
--
----
-
--
IA
VVV
Y
LLR
Y
VW
R
V
L
LFG
A
SYQ
LA
VE
LR
E
D
YYRQLS
RQ
H
P
E
F
YL
R
H
R
TG
D
L
M
A
R
A
TND
V
D
-------
R
VV
FAAGEGVL
T
L
V
-
-D
S
LV
M
G
CAV
L
I
M
M
ST
QI
SWQL
---
T
L
F
AL
L
P
M
PV
M
AI
MIKRNG
D
ALHE
RF
K
LAQ
A
AFS
S
L
ND
RTQE
S
LTS
I
--
-
-RM
I
KA
FG
-----------
LED
R
QSALFAADAEDTGKKN
M
R
VA
R
I
D
A
-
RF
DP
T
I
Y
I
AI
GM
A
N
--
LL
A
I
G
G
G
S
WMV
A
Q
GSLT
L
G
Q
LT
S
F
M
M
YLG
L
M
IW
P
M
LA
L
A
WM
FNIVERG
S
A
AY
S
R
IR
A
M
LAEA
P
V
V
N
DG
S
E
PV
PE
----
----
-
--G
RG
E
L
DV
N
IH
--
Q
FTYP
QT
D
H
PAL
E
N
V
N
F
A
L
K
P
G
QM
LGIC
G
P
TGSGKSTL
L
SLI
Q
R
H
F
D
V
S
EG
D
IR
F
HD
I
PL
TK
L
Q
L
D
S
W
R
SR
L
A
V
VSQ
T
P
F
LF
S
DTVANNIALG
-
CPNA
T
Q
Q
E
IE
H
V
AR
L
A
SVH
D
D
I
LR
L
PQ
G
Y
DT
E
V
GE
R
GV
M
LSGGQKQRI
S
IARALL
VNAE
ILILD
D
A
L
SA
V
D
GR
TE
H
Q
I
L
H
N
L
RQWG
Q
G
RT
V
I
IS
AHRLS
AL
T
E
A
S
EI
I
V
M
QH
G
H
I
AQ
RG
N
H
DE
L
A
QQS
G
W
Y
R
D
MY
R
Y
Q
QL
EAA
L
DDAPE
I
R
E
E
fig|749532.3.peg.4728
Escherichia coli MS 78-1 (1-586/590)
MR
L
F
A
QL
S
W
Y
FRR
E
------
W
--------
R
R
YLG
A
VALL
VI
--
-
--IA
ML
Q
L
VP
P
KVVGIVV
DG
VTEQHF
T
TGQ
I
L
M
W
I
A
TM
V
L
--
--
----
-
--
IA
VVV
Y
LLR
Y
VW
R
V
L
LFG
A
SYQ
LA
VE
LR
E
D
YYRQLS
RQ
H
P
E
F
YL
R
H
R
TG
D
L
M
A
R
A
TND
V
D
-------
R
VV
FAAGEGVL
T
L
V
-
-D
S
LV
M
G
CAV
L
I
M
M
ST
QI
SWQL
---
T
L
F
AL
L
P
M
PV
M
AI
MIKRNG
D
ALHE
RF
K
LAQ
A
AFS
S
L
ND
RTQE
S
LTS
I
--
-
-RM
I
KA
FG
-----------
LED
R
QSALFAADAEDTGKKN
M
R
VA
R
I
D
A
-
RF
DP
T
I
Y
I
AI
GM
A
N
--
LL
A
I
G
G
G
S
WMV
A
Q
GSLT
L
G
Q
LT
S
F
M
M
YLG
L
M
IW
P
M
LA
L
A
WM
FNIVERG
S
A
AY
S
R
IR
A
M
LAEA
P
V
V
N
DG
S
E
PV
PE
----
----
-
--G
RG
E
L
DV
N
IH
--
Q
FTYP
QT
D
H
PAL
E
N
V
N
F
A
L
K
P
G
QM
LGIC
G
P
TGSGKSTL
L
SLI
Q
R
H
F
D
V
S
EG
D
IR
F
HD
I
PL
TK
L
Q
L
D
S
W
R
SR
L
A
V
VSQ
T
P
F
LF
S
DTVANNIALG
-
CPNA
T
Q
Q
E
IE
H
V
AR
L
A
SVH
D
D
I
LR
L
PQ
G
Y
DT
E
V
GE
R
GV
M
LSGGQKQRI
S
IARALL
VNAE
ILILD
D
A
L
SA
V
D
GR
TE
H
Q
I
L
H
N
L
RQWG
Q
G
RT
V
I
IS
AHRLS
AL
T
E
A
S
EI
I
V
M
QH
G
H
I
AQ
RG
N
H
DE
L
A
QQS
G
W
Y
R
D
MY
R
Y
Q
QL
EAA
L
DDAPE
I
R
E
E
fig|585395.4.peg.448
Escherichia coli O103:H2 str. 12009 (1-586/590)
MR
L
F
A
QL
S
W
Y
FRR
E
------
W
--------
R
R
YLG
A
VALL
VI
--
-
--IA
ML
Q
L
VP
P
KVVGIVV
DG
VTEQHF
T
TGQ
I
L
M
W
I
A
TM
V
L
--
--
----
-
--
IA
VVV
Y
LLR
Y
VW
R
V
L
LFG
A
SYQ
LA
VE
LR
E
D
YYRQLS
RQ
H
P
E
F
YL
R
H
R
TG
D
L
M
A
R
A
TND
V
D
-------
R
VV
FAAGEGVL
T
L
V
-
-D
S
LV
M
G
CAV
L
I
M
M
ST
QI
SWQL
---
T
L
F
AL
L
P
M
PV
M
AI
MIKRNG
D
ALHE
RF
K
LAQ
A
AFS
S
L
ND
RTQE
S
LTS
I
--
-
-RM
I
KA
FG
-----------
LED
R
QSALFAADAEDTGKKN
M
R
VA
R
I
D
A
-
RF
DP
T
I
Y
I
AI
GM
A
N
--
LL
A
I
G
G
G
S
WMV
A
Q
GSLT
L
G
Q
LT
S
F
M
M
YLG
L
M
IW
P
M
LA
L
A
WM
FNIVERG
S
A
AY
S
R
IR
A
M
LAEA
P
V
V
N
DG
S
E
PV
PE
----
----
-
--G
RG
E
L
DV
N
IH
--
Q
FTYP
QT
D
H
PAL
E
N
V
N
F
A
L
K
P
G
QM
LGIC
G
P
TGSGKSTL
L
SLI
Q
R
H
F
D
V
S
EG
D
IR
F
HD
I
PL
TK
L
Q
L
D
S
W
R
SR
L
A
V
VSQ
T
P
F
LF
S
DTVANNIALG
-
CPNA
T
Q
Q
E
IE
H
V
AR
L
A
SVH
D
D
I
LR
L
PQ
G
Y
DT
E
V
GE
R
GV
M
LSGGQKQRI
S
IARALL
VNAE
ILILD
D
A
L
SA
V
D
GR
TE
H
Q
I
L
H
N
L
RQWG
Q
G
RT
V
I
IS
AHRLS
AL
T
E
A
S
EI
I
V
M
QH
G
H
I
AQ
RG
N
H
DE
L
A
QQS
G
W
Y
R
D
MY
R
Y
Q
QL
EAA
L
DDAPE
I
R
E
E
fig|431946.3.peg.424
Escherichia coli SE15 (1-586/590)
MR
L
F
A
QL
S
W
Y
FRR
E
------
W
--------
R
R
YLG
A
VALL
VI
--
-
--IA
ML
Q
L
VP
P
KVVGIVV
DG
VTEQHF
T
TGQ
I
L
M
W
I
A
TM
V
L
--
--
----
-
--
IA
VVV
Y
LLR
Y
VW
R
V
L
LFG
A
SYQ
LA
VE
LR
E
D
YYRQLS
RQ
H
P
E
F
YL
R
H
R
TG
D
L
M
A
R
A
TND
V
D
-------
R
VV
FAAGEGVL
T
L
V
-
-D
S
LV
M
G
CAV
L
I
M
M
ST
QI
SWQL
---
T
L
F
AL
L
P
M
PV
M
AI
MIKRNG
D
ALHE
RF
K
LAQ
A
AFS
S
L
ND
RTQE
S
LTS
I
--
-
-RM
I
KA
FG
-----------
LED
R
QSALFAADAEDTGKKN
M
R
VA
R
I
D
A
-
RF
DP
T
I
Y
I
AI
GM
A
N
--
LL
A
I
G
G
G
S
WMV
V
Q
GSLT
L
G
Q
LT
S
F
M
M
YLG
L
M
IW
P
M
LA
L
A
WM
FNIVERG
S
A
AY
S
R
IR
T
M
LAEA
P
V
V
I
DG
S
D
KV
PE
----
----
-
--G
RG
E
L
DV
N
IR
--
Q
FTYP
QT
D
H
PAL
E
N
V
N
F
A
L
K
P
G
QM
V
GIC
G
P
TGSGKSTL
L
SLI
Q
R
H
F
D
V
S
EG
D
IR
F
HD
I
PL
TK
L
Q
L
D
S
W
R
SR
L
A
V
VSQ
T
P
F
LF
S
DTVANNIALG
-
CPNA
T
Q
Q
E
IE
H
V
AR
L
A
SVH
D
D
I
LR
L
PQ
G
Y
DT
E
V
GE
R
GV
M
LSGGQKQRI
S
IARALL
VNAE
ILILD
D
A
L
SA
V
D
GR
TE
H
Q
I
L
H
N
L
RQWG
Q
G
RT
V
I
IS
AHRLS
AL
T
E
A
S
EI
I
V
M
QH
G
H
I
AQ
RG
N
H
DV
L
V
QQS
G
W
Y
R
D
MY
R
Y
Q
QL
EAA
L
DDAPE
I
R
E
E
fig|714962.3.peg.441
Escherichia coli IHE3034 (1-586/590)
MR
L
F
A
QL
S
W
Y
FRR
E
------
W
--------
R
R
YLG
A
VALL
VI
--
-
--IA
ML
Q
L
VP
P
KVVGIVV
DG
VTEQHF
T
TGQ
I
L
M
W
I
A
TM
V
L
--
--
----
-
--
IA
VVV
Y
LLR
Y
VW
R
V
L
LFG
A
SYQ
LA
VE
LR
E
D
YYRQLS
RQ
H
P
E
F
YL
R
H
R
TG
D
L
M
A
R
A
TND
V
D
-------
R
VV
FAAGEGVL
T
L
V
-
-D
S
LV
M
G
CAV
L
I
M
M
ST
QI
SWQL
---
T
L
F
AL
L
P
M
PV
M
AI
MIKRNG
D
ALHE
RF
K
LAQ
A
AFS
S
L
ND
RTQE
S
LTS
I
--
-
-RM
I
KA
FG
-----------
LED
R
QSALFAADAEDTGKKN
M
R
VA
R
I
D
A
-
RF
DP
T
I
Y
I
AI
GM
A
N
--
LL
A
I
G
G
G
S
WMV
V
Q
GSLT
L
G
Q
LT
S
F
I
M
YLG
L
M
IW
P
M
LA
L
A
WM
FNIVERG
S
A
AY
S
R
IR
T
M
LAEA
P
V
V
I
DG
S
D
KV
PE
----
----
-
--G
RG
E
L
DV
N
IR
--
Q
FTYP
QT
D
H
PAL
E
N
V
N
F
A
L
K
P
G
QM
V
GIC
G
P
TGSGKSTL
L
SLI
Q
R
H
F
D
V
S
EG
D
IR
F
HD
I
PL
TK
L
Q
L
D
S
W
R
SR
L
A
V
VSQ
T
P
F
LF
S
DTVANNIALG
-
CPNA
I
Q
Q
E
IE
H
V
AR
L
A
SVH
D
D
I
LR
L
PQ
G
Y
DT
E
V
GE
R
GV
M
LSGGQKQRI
S
IARALL
VNAE
ILILD
D
A
L
SA
V
D
GR
TE
H
Q
I
L
H
N
L
RQWG
Q
G
RT
V
I
IS
AHRLS
AL
T
E
A
S
EI
I
V
M
QH
G
H
I
G
Q
RG
N
H
DV
L
V
QQS
G
W
Y
R
D
MY
R
Y
Q
QL
EAA
L
DDAPE
I
R
E
E
fig|585035.6.peg.444
Escherichia coli S88 (1-586/590)
MR
L
F
A
QL
S
W
Y
FRR
E
------
W
--------
R
R
YLG
A
VALL
VI
--
-
--IA
ML
Q
L
VP
P
KVVGIVV
DG
VTEQHF
T
TGQ
I
L
M
W
I
A
TM
V
L
--
--
----
-
--
IA
VVV
Y
LLR
Y
VW
R
V
L
LFG
A
SYQ
LA
VE
LR
E
D
YYRQLS
RQ
H
P
E
F
YL
R
H
R
TG
D
L
M
A
R
A
TND
V
D
-------
R
VV
FAAGEGVL
T
L
V
-
-D
S
LV
M
G
CAV
L
I
M
M
ST
QI
SWQL
---
T
L
F
AL
L
P
M
PV
M
AI
MIKRNG
D
ALHE
RF
K
LAQ
A
AFS
S
L
ND
RTQE
S
LTS
I
--
-
-RM
I
KA
FG
-----------
LED
R
QSALFAADAEDTGKKN
M
R
VA
R
I
D
A
-
RF
DP
T
I
Y
I
AI
GM
A
N
--
LL
A
I
G
G
G
S
WMV
V
Q
GSLT
L
G
Q
LT
S
F
I
M
YLG
L
M
IW
P
M
LA
L
A
WM
FNIVERG
S
A
AY
S
R
IR
T
M
LAEA
P
V
V
I
DG
S
D
KV
PE
----
----
-
--G
RG
E
L
DV
N
IR
--
Q
FTYP
QT
D
H
PAL
E
N
V
N
F
A
L
K
P
G
QM
V
GIC
G
P
TGSGKSTL
L
SLI
Q
R
H
F
D
V
S
EG
D
IR
F
HD
I
PL
TK
L
Q
L
D
S
W
R
SR
L
A
V
VSQ
T
P
F
LF
S
DTVANNIALG
-
CPNA
I
Q
Q
E
IE
H
V
AR
L
A
SVH
D
D
I
LR
L
PQ
G
Y
DT
E
V
GE
R
GV
M
LSGGQKQRI
S
IARALL
VNAE
ILILD
D
A
L
SA
V
D
GR
TE
H
Q
I
L
H
N
L
RQWG
Q
G
RT
V
I
IS
AHRLS
AL
T
E
A
S
EI
I
V
M
QH
G
H
I
G
Q
RG
N
H
DV
L
V
QQS
G
W
Y
R
D
MY
R
Y
Q
QL
EAA
L
DDAPE
I
R
E
E
fig|869729.3.peg.3236
Escherichia coli UM146 (1-586/590)
MR
L
F
A
QL
S
W
Y
FRR
E
------
W
--------
R
R
YLG
A
VALL
VI
--
-
--IA
ML
Q
L
VP
P
KVVGIVV
DG
VTEQHF
T
TGQ
I
L
M
W
I
A
TM
V
L
--
--
----
-
--
IA
VVV
Y
LLR
Y
VW
R
V
L
LFG
A
SYQ
LA
VE
LR
E
D
YYRQLS
RQ
H
P
E
F
YL
R
H
R
TG
D
L
M
A
R
A
TND
V
D
-------
R
VV
FAAGEGVL
T
L
V
-
-D
S
LV
M
G
CAV
L
I
M
M
ST
QI
SWQL
---
T
L
F
AL
L
P
M
PV
M
AI
MIKRNG
D
ALHE
RF
K
LAQ
A
AFS
S
L
ND
RTQE
S
LTS
I
--
-
-RM
I
KA
FG
-----------
LED
R
QSALFAADAEDTGKKN
M
R
VA
R
I
D
A
-
RF
DP
T
I
Y
I
AI
GM
A
N
--
LL
A
I
G
G
G
S
WMV
V
Q
GSLT
L
G
Q
LT
S
F
I
M
YLG
L
M
IW
P
M
LA
L
A
WM
FNIVERG
S
A
AY
S
R
IR
T
M
LAEA
P
V
V
I
DG
S
D
KV
PE
----
----
-
--G
RG
E
L
DV
N
IR
--
Q
FTYP
QT
D
H
PAL
E
N
V
N
F
A
L
K
P
G
QM
V
GIC
G
P
TGSGKSTL
L
SLI
Q
R
H
F
D
V
S
EG
D
IR
F
HD
I
PL
TK
L
Q
L
D
S
W
R
SR
L
A
V
VSQ
T
P
F
LF
S
DTVANNIALG
-
CPNA
I
Q
Q
E
IE
H
V
AR
L
A
SVH
D
D
I
LR
L
PQ
G
Y
DT
E
V
GE
R
GV
M
LSGGQKQRI
S
IARALL
VNAE
ILILD
D
A
L
SA
V
D
GR
TE
H
Q
I
L
H
N
L
RQWG
Q
G
RT
V
I
IS
AHRLS
AL
T
E
A
S
EI
I
V
M
QH
G
H
I
G
Q
RG
N
H
DV
L
V
QQS
G
W
Y
R
D
MY
R
Y
Q
QL
EAA
L
DDAPE
I
R
E
E
fig|364106.7.peg.582
Escherichia coli UTI89 (1-586/590)
MR
L
F
A
QL
S
W
Y
FRR
E
------
W
--------
R
R
YLG
A
VALL
VI
--
-
--IA
ML
Q
L
VP
P
KVVGIVV
DG
VTEQHF
T
TGQ
I
L
M
W
I
A
TM
V
L
--
--
----
-
--
IA
VVV
Y
LLR
Y
VW
R
V
L
LFG
A
SYQ
LA
VE
LR
E
D
YYRQLS
RQ
H
P
E
F
YL
R
H
R
TG
D
L
M
A
R
A
TND
V
D
-------
R
VV
FAAGEGVL
T
L
V
-
-D
S
LV
M
G
CAV
L
I
M
M
ST
QI
SWQL
---
T
L
F
AL
L
P
M
PV
M
AI
MIKRNG
D
ALHE
RF
K
LAQ
A
AFS
S
L
ND
RTQE
S
LTS
I
--
-
-RM
I
KA
FG
-----------
LED
R
QSALFAADAEDTGKKN
M
R
VA
R
I
D
A
-
RF
DP
T
I
Y
I
AI
GM
A
N
--
LL
A
I
G
G
G
S
WMV
V
Q
GSLT
L
G
Q
LT
S
F
I
M
YLG
L
M
IW
P
M
LA
L
A
WM
FNIVERG
S
A
AY
S
R
IR
T
M
LAEA
P
V
V
I
DG
S
D
KV
PE
----
----
-
--G
RG
E
L
DV
N
IR
--
Q
FTYP
QT
D
H
PAL
E
N
V
N
F
A
L
K
P
G
QM
V
GIC
G
P
TGSGKSTL
L
SLI
Q
R
H
F
D
V
S
EG
D
IR
F
HD
I
PL
TK
L
Q
L
D
S
W
R
SR
L
A
V
VSQ
T
P
F
LF
S
DTVANNIALG
-
CPNA
I
Q
Q
E
IE
H
V
AR
L
A
SVH
D
D
I
LR
L
PQ
G
Y
DT
E
V
GE
R
GV
M
LSGGQKQRI
S
IARALL
VNAE
ILILD
D
A
L
SA
V
D
GR
TE
H
Q
I
L
H
N
L
RQWG
Q
G
RT
V
I
IS
AHRLS
AL
T
E
A
S
EI
I
V
M
QH
G
H
I
G
Q
RG
N
H
DV
L
V
QQS
G
W
Y
R
D
MY
R
Y
Q
QL
EAA
L
DDAPE
I
R
E
E
fig|364106.8.peg.580
Escherichia coli UTI89 (1-586/590)
MR
L
F
A
QL
S
W
Y
FRR
E
------
W
--------
R
R
YLG
A
VALL
VI
--
-
--IA
ML
Q
L
VP
P
KVVGIVV
DG
VTEQHF
T
TGQ
I
L
M
W
I
A
TM
V
L
--
--
----
-
--
IA
VVV
Y
LLR
Y
VW
R
V
L
LFG
A
SYQ
LA
VE
LR
E
D
YYRQLS
RQ
H
P
E
F
YL
R
H
R
TG
D
L
M
A
R
A
TND
V
D
-------
R
VV
FAAGEGVL
T
L
V
-
-D
S
LV
M
G
CAV
L
I
M
M
ST
QI
SWQL
---
T
L
F
AL
L
P
M
PV
M
AI
MIKRNG
D
ALHE
RF
K
LAQ
A
AFS
S
L
ND
RTQE
S
LTS
I
--
-
-RM
I
KA
FG
-----------
LED
R
QSALFAADAEDTGKKN
M
R
VA
R
I
D
A
-
RF
DP
T
I
Y
I
AI
GM
A
N
--
LL
A
I
G
G
G
S
WMV
V
Q
GSLT
L
G
Q
LT
S
F
I
M
YLG
L
M
IW
P
M
LA
L
A
WM
FNIVERG
S
A
AY
S
R
IR
T
M
LAEA
P
V
V
I
DG
S
D
KV
PE
----
----
-
--G
RG
E
L
DV
N
IR
--
Q
FTYP
QT
D
H
PAL
E
N
V
N
F
A
L
K
P
G
QM
V
GIC
G
P
TGSGKSTL
L
SLI
Q
R
H
F
D
V
S
EG
D
IR
F
HD
I
PL
TK
L
Q
L
D
S
W
R
SR
L
A
V
VSQ
T
P
F
LF
S
DTVANNIALG
-
CPNA
I
Q
Q
E
IE
H
V
AR
L
A
SVH
D
D
I
LR
L
PQ
G
Y
DT
E
V
GE
R
GV
M
LSGGQKQRI
S
IARALL
VNAE
ILILD
D
A
L
SA
V
D
GR
TE
H
Q
I
L
H
N
L
RQWG
Q
G
RT
V
I
IS
AHRLS
AL
T
E
A
S
EI
I
V
M
QH
G
H
I
G
Q
RG
N
H
DV
L
V
QQS
G
W
Y
R
D
MY
R
Y
Q
QL
EAA
L
DDAPE
I
R
E
E
fig|749527.3.peg.1903
Escherichia coli MS 21-1 (1-586/590)
MR
L
F
A
QL
S
W
Y
FRR
E
------
W
--------
R
R
YLG
A
VALL
VI
--
-
--IA
ML
Q
L
VP
P
KVVGIVV
DG
VTEQHF
T
TGQ
I
L
M
W
I
A
TM
V
L
--
--
----
-
--
IA
VVV
Y
LLR
Y
VW
R
V
L
LFG
A
SYQ
LA
VE
LR
E
D
YYRQLS
RQ
H
P
E
F
YL
R
H
R
TG
D
L
M
A
R
A
TND
V
D
-------
R
VV
FAAGEGVL
T
L
V
-
-D
S
LV
M
G
CAV
L
I
M
M
ST
QI
SWQL
---
T
L
F
AL
L
P
M
PV
M
AI
MIKRNG
D
ALHE
RF
K
LAQ
A
AFS
S
L
ND
RTQE
S
LTS
I
--
-
-RM
I
KA
FG
-----------
LED
R
QSALFAADAEDTGKKN
M
R
VA
R
I
D
A
-
RF
DP
T
I
Y
I
AI
GM
A
N
--
LL
A
I
G
G
G
S
WMV
V
Q
GSLT
L
G
Q
LT
S
F
M
M
YLG
L
M
IW
P
M
LA
L
A
WM
FNIVERG
S
A
AY
S
R
IR
A
M
LAEA
P
V
V
N
DG
S
E
PV
PE
----
----
-
--G
RG
E
L
DV
N
IR
--
Q
FTYP
QT
D
H
PAL
E
N
V
N
F
A
L
K
P
G
QM
V
GIC
G
P
TGSGKSTL
L
SLI
Q
R
H
F
D
V
S
EG
D
IR
F
HD
I
PL
TK
L
Q
L
D
S
W
R
SR
L
A
V
VSQ
T
P
F
LF
S
DTVANNIALG
-
CPNA
T
Q
Q
E
IE
H
V
AR
L
A
SVH
D
D
I
LR
L
PQ
G
Y
DT
E
V
GE
R
GV
M
LSGGQKQRI
S
IARALL
VNAE
ILILD
D
A
L
SA
V
D
GR
TE
H
Q
I
L
H
N
L
RQWG
Q
G
RT
V
I
IS
AHRLS
AL
T
E
A
S
EI
I
V
M
QH
G
H
I
AQ
RG
N
H
DE
L
A
QQS
G
W
Y
R
D
MY
R
Y
Q
QL
EAA
L
DDAPE
I
R
E
E
fig|573235.3.peg.489
Escherichia coli O26:H11 str. 11368 (1-586/590)
MR
L
F
A
QL
S
W
Y
FRR
E
------
W
--------
R
R
YLG
A
VALL
VI
--
-
--IA
ML
Q
L
VP
P
KVVGIVV
DG
VTEQHF
T
TGL
I
L
M
W
I
A
TM
V
L
--
--
----
-
--
IA
VVV
Y
LLR
Y
VW
R
V
L
LFG
A
SYQ
LA
VE
LR
E
D
YYRQLS
RQ
H
P
E
F
YL
R
H
R
TG
D
L
M
A
R
A
TND
V
D
-------
R
VV
FAAGEGVL
T
L
V
-
-D
S
LV
M
G
CAV
L
I
M
M
ST
QI
SWQL
---
T
L
F
AL
L
P
M
PV
M
AI
MIKRNG
D
ALHE
RF
K
LAQ
A
AFS
S
L
ND
RTQE
S
LTS
I
--
-
-RM
I
KA
FG
-----------
LED
R
QSALFAADAEDTGKKN
M
R
VA
R
I
D
A
-
RF
DP
T
I
Y
I
AI
GM
A
N
--
LL
A
I
G
G
G
S
WMV
V
Q
GSLT
L
G
Q
LT
S
F
M
M
YLG
L
M
IW
P
M
LA
L
A
WM
FNIVERG
S
A
AY
S
R
IR
A
M
LAEA
P
V
V
N
DG
S
E
PV
PE
----
----
-
--G
RG
E
L
DV
N
IH
--
Q
FTYP
QT
D
H
R
AL
E
N
V
N
F
A
L
K
P
G
QM
LGIC
G
P
TGSGKSTL
L
SLI
Q
R
H
F
D
V
S
EG
D
IR
F
HD
I
PL
TK
L
Q
L
D
S
W
R
SR
L
A
V
VSQ
T
P
F
LF
S
DTVANNIALG
-
CPNA
T
Q
Q
E
IE
H
V
AR
L
A
SVH
D
D
I
LR
L
PQ
G
Y
DT
E
V
GE
R
GV
M
LSGGQKQRI
S
IARALL
VNAE
ILILD
D
A
L
SA
V
D
GR
TE
H
Q
I
L
H
N
L
RQWG
Q
G
RT
V
I
IS
AHRLS
AL
T
E
A
S
EI
I
V
M
QH
G
H
I
AQ
RG
N
H
DE
L
A
QQS
G
W
Y
R
D
MY
R
Y
Q
QL
EAA
L
DDAPE
I
R
E
E
fig|753642.3.peg.1185
Escherichia coli NC101 (1-586/590)
MR
L
F
A
QL
S
W
Y
FRR
E
------
W
--------
R
R
YLG
A
VALL
VI
--
-
--IA
ML
Q
L
VP
P
KVVGIVV
DG
VTEQHF
T
TGQ
I
L
M
W
I
A
TM
V
L
--
--
----
-
--
IA
VVV
Y
LLR
Y
VW
R
V
L
LFG
A
SYQ
LA
VE
LR
E
D
YYRQLS
RQ
H
P
E
F
YL
R
H
R
TG
D
L
M
A
R
A
TND
V
D
-------
R
VV
FAAGEGVL
T
L
V
-
-D
S
LV
M
G
CAV
L
I
M
M
ST
QI
SWQL
---
T
L
F
AL
L
P
M
PV
M
AI
MIKRNG
D
ALHE
RF
K
LAQ
A
AFS
S
L
ND
RTQE
S
LTS
I
--
-
-RM
I
KA
FG
-----------
LED
R
QSALFAADAEDTGKKN
M
R
VA
R
I
D
A
-
RF
DP
T
I
Y
I
AI
GM
A
N
--
LL
A
I
G
G
G
S
WMV
V
Q
GSLT
L
G
Q
LT
S
F
M
M
YLG
L
M
IW
P
M
LA
L
A
WM
FNIVERG
S
A
AY
S
R
IR
T
M
LAEA
P
V
V
I
DG
S
D
KV
PE
----
----
-
--G
RG
E
L
DV
N
IR
--
Q
FTYP
QT
D
H
PAL
E
N
V
N
F
A
L
K
P
C
QM
LGIC
G
P
TGSGKSTL
L
SLI
Q
R
H
F
D
V
S
EG
D
IR
F
HD
I
PL
TK
L
Q
L
D
S
W
R
SR
L
A
V
VSQ
T
P
F
LF
S
DTVANNIALG
-
CPNA
T
Q
Q
E
IE
H
V
AR
L
A
SVH
D
D
I
LR
L
PQ
G
F
DT
E
V
GE
R
GV
M
LSGGQKQRI
S
IARALL
VNAE
ILILD
D
A
L
SA
V
D
GR
TE
H
Q
I
L
H
N
L
RQWG
Q
G
RT
V
I
IS
AHRLS
AL
T
E
A
S
EI
I
V
M
QH
G
H
I
AQ
RG
N
H
DE
L
A
QQS
G
W
Y
R
D
MY
R
Y
Q
QL
EAA
L
DDAPE
I
R
E
E
fig|585397.7.peg.473
Escherichia coli ED1a (1-586/590)
MR
L
F
A
QL
S
W
Y
FRR
E
------
W
--------
R
R
YLG
A
VALL
VI
--
-
--IA
ML
Q
L
VP
P
KVVGIVV
DG
VTEQHF
T
TGQ
I
L
M
W
I
A
TM
V
L
--
--
----
-
--
IA
VVV
Y
LLR
Y
VW
R
V
L
LFG
A
SYQ
LA
VE
LR
E
D
YYRQLS
RQ
H
P
E
F
YL
R
H
R
TG
D
L
M
A
R
A
TND
V
D
-------
R
VV
FAAGEGVL
T
L
V
-
-D
S
LV
M
G
CAV
L
I
M
M
ST
QI
SWQL
---
T
L
F
AL
L
P
M
PV
M
AI
MIKRNG
D
ALHE
RF
K
LAQ
A
AFS
S
L
ND
RTQE
S
LTS
I
--
-
-RM
I
KA
FG
-----------
LED
R
QSALFAADAEDTGKKN
M
R
VA
R
I
D
A
-
RF
DP
T
I
Y
I
AI
GM
A
N
--
LL
A
I
G
G
G
S
WMV
V
Q
GSLT
L
G
Q
LT
S
F
M
M
YLG
L
M
IW
P
M
LA
L
A
WM
FNIVERG
S
A
AY
S
R
IR
T
M
LAEA
P
V
V
I
DG
S
D
KV
PE
----
----
-
--G
RG
E
L
DV
N
IR
--
Q
FTYP
QT
D
H
PAL
E
N
V
N
F
A
L
K
P
G
QM
V
GIC
G
P
TGSGKSTL
L
SLI
Q
R
H
F
D
V
S
EG
D
IR
F
HD
I
PL
TK
L
Q
L
D
S
W
R
SR
L
A
V
VSQ
T
P
F
LF
S
DTVANNIALG
-
CPNA
T
Q
Q
E
IE
H
V
AR
L
A
SVH
D
D
I
LR
L
PQ
G
Y
DT
E
V
GE
R
GV
M
LSGGQKQRI
S
IARALL
VNAE
ILILD
D
A
L
SA
V
D
GR
TE
H
Q
I
L
H
N
L
RQWG
Q
G
RT
V
I
IS
AHRLS
AL
T
E
A
S
EI
I
V
M
LH
G
H
I
AQ
RG
N
H
DE
L
A
QQS
G
W
Y
R
D
MY
R
Y
Q
QL
EAA
L
DDAPE
I
R
E
E
fig|585397.9.peg.475
Escherichia coli ED1a (1-586/590)
MR
L
F
A
QL
S
W
Y
FRR
E
------
W
--------
R
R
YLG
A
VALL
VI
--
-
--IA
ML
Q
L
VP
P
KVVGIVV
DG
VTEQHF
T
TGQ
I
L
M
W
I
A
TM
V
L
--
--
----
-
--
IA
VVV
Y
LLR
Y
VW
R
V
L
LFG
A
SYQ
LA
VE
LR
E
D
YYRQLS
RQ
H
P
E
F
YL
R
H
R
TG
D
L
M
A
R
A
TND
V
D
-------
R
VV
FAAGEGVL
T
L
V
-
-D
S
LV
M
G
CAV
L
I
M
M
ST
QI
SWQL
---
T
L
F
AL
L
P
M
PV
M
AI
MIKRNG
D
ALHE
RF
K
LAQ
A
AFS
S
L
ND
RTQE
S
LTS
I
--
-
-RM
I
KA
FG
-----------
LED
R
QSALFAADAEDTGKKN
M
R
VA
R
I
D
A
-
RF
DP
T
I
Y
I
AI
GM
A
N
--
LL
A
I
G
G
G
S
WMV
V
Q
GSLT
L
G
Q
LT
S
F
M
M
YLG
L
M
IW
P
M
LA
L
A
WM
FNIVERG
S
A
AY
S
R
IR
T
M
LAEA
P
V
V
I
DG
S
D
KV
PE
----
----
-
--G
RG
E
L
DV
N
IR
--
Q
FTYP
QT
D
H
PAL
E
N
V
N
F
A
L
K
P
G
QM
V
GIC
G
P
TGSGKSTL
L
SLI
Q
R
H
F
D
V
S
EG
D
IR
F
HD
I
PL
TK
L
Q
L
D
S
W
R
SR
L
A
V
VSQ
T
P
F
LF
S
DTVANNIALG
-
CPNA
T
Q
Q
E
IE
H
V
AR
L
A
SVH
D
D
I
LR
L
PQ
G
Y
DT
E
V
GE
R
GV
M
LSGGQKQRI
S
IARALL
VNAE
ILILD
D
A
L
SA
V
D
GR
TE
H
Q
I
L
H
N
L
RQWG
Q
G
RT
V
I
IS
AHRLS
AL
T
E
A
S
EI
I
V
M
LH
G
H
I
AQ
RG
N
H
DE
L
A
QQS
G
W
Y
R
D
MY
R
Y
Q
QL
EAA
L
DDAPE
I
R
E
E
fig|358709.5.peg.2106
Escherichia coli 101-1 (1-586/590)
MR
L
F
A
QL
S
W
Y
FRR
E
------
W
--------
R
R
YLG
A
VALL
VI
--
-
--IA
ML
Q
L
VP
P
KVVGIVV
DG
VTEQHF
T
TGL
I
L
M
W
I
A
TM
V
L
--
--
----
-
--
IA
VVV
Y
LLR
Y
VW
R
V
L
LFG
A
SYQ
LA
VE
LR
E
D
YYRQLS
RQ
H
P
E
F
YL
R
H
R
TG
D
L
M
A
R
A
TND
V
D
-------
R
VV
FAAGEGVL
T
L
V
-
-D
S
LV
M
G
CAV
L
I
M
M
ST
QI
SWQL
---
T
L
F
AL
L
P
M
PV
M
AI
MIKRNG
D
ALHE
RF
K
LAQ
A
AFS
S
L
ND
RTQE
S
LTS
I
--
-
-RM
I
KA
FG
-----------
LED
R
QSALFAADAEDTGKKN
M
R
VA
R
I
D
A
-
RF
DP
T
I
Y
I
AI
GM
A
N
--
LL
A
I
G
G
G
S
WMV
V
Q
GSLT
L
G
Q
LT
S
F
M
M
YLG
L
M
IW
P
M
LA
L
A
WM
FNIVERG
S
A
AY
S
R
IR
A
M
LAEA
P
V
V
N
DG
S
E
PV
PE
----
----
-
--G
RG
E
L
DV
N
IH
--
Q
FTYP
QT
D
H
PAL
E
N
V
N
F
A
L
K
P
G
QM
LGIC
G
P
TGSGKSTL
L
SLI
Q
R
H
F
D
V
S
EG
D
IR
F
HD
I
PL
TK
L
Q
L
D
S
W
R
SR
L
A
V
VSQ
T
P
F
LF
S
DTVANNIALG
-
CPNA
T
Q
Q
E
IE
H
V
AR
L
A
SVH
D
D
I
LR
L
PQ
G
Y
DT
E
V
GE
R
GV
M
LSGGQKQRI
S
IARALL
VNAE
ILILD
D
A
L
SA
V
D
GR
TE
H
Q
I
L
H
N
L
RQWG
Q
G
RT
V
I
IS
AHRLS
AL
T
E
A
S
EI
I
V
M
QH
G
H
I
AQ
RG
N
H
DE
L
A
QQS
G
W
Y
R
D
MY
R
Y
Q
QL
EAA
L
DDAPE
I
R
E
E
fig|413997.3.peg.430
Escherichia coli B str. REL606 (1-586/590)
MR
L
F
A
QL
S
W
Y
FRR
E
------
W
--------
R
R
YLG
A
VALL
VI
--
-
--IA
ML
Q
L
VP
P
KVVGIVV
DG
VTEQHF
T
TGL
I
L
M
W
I
A
TM
V
L
--
--
----
-
--
IA
VVV
Y
LLR
Y
VW
R
V
L
LFG
A
SYQ
LA
VE
LR
E
D
YYRQLS
RQ
H
P
E
F
YL
R
H
R
TG
D
L
M
A
R
A
TND
V
D
-------
R
VV
FAAGEGVL
T
L
V
-
-D
S
LV
M
G
CAV
L
I
M
M
ST
QI
SWQL
---
T
L
F
AL
L
P
M
PV
M
AI
MIKRNG
D
ALHE
RF
K
LAQ
A
AFS
S
L
ND
RTQE
S
LTS
I
--
-
-RM
I
KA
FG
-----------
LED
R
QSALFAADAEDTGKKN
M
R
VA
R
I
D
A
-
RF
DP
T
I
Y
I
AI
GM
A
N
--
LL
A
I
G
G
G
S
WMV
V
Q
GSLT
L
G
Q
LT
S
F
M
M
YLG
L
M
IW
P
M
LA
L
A
WM
FNIVERG
S
A
AY
S
R
IR
A
M
LAEA
P
V
V
N
DG
S
E
PV
PE
----
----
-
--G
RG
E
L
DV
N
IH
--
Q
FTYP
QT
D
H
PAL
E
N
V
N
F
A
L
K
P
G
QM
LGIC
G
P
TGSGKSTL
L
SLI
Q
R
H
F
D
V
S
EG
D
IR
F
HD
I
PL
TK
L
Q
L
D
S
W
R
SR
L
A
V
VSQ
T
P
F
LF
S
DTVANNIALG
-
CPNA
T
Q
Q
E
IE
H
V
AR
L
A
SVH
D
D
I
LR
L
PQ
G
Y
DT
E
V
GE
R
GV
M
LSGGQKQRI
S
IARALL
VNAE
ILILD
D
A
L
SA
V
D
GR
TE
H
Q
I
L
H
N
L
RQWG
Q
G
RT
V
I
IS
AHRLS
AL
T
E
A
S
EI
I
V
M
QH
G
H
I
AQ
RG
N
H
DE
L
A
QQS
G
W
Y
R
D
MY
R
Y
Q
QL
EAA
L
DDAPE
I
R
E
E
fig|511693.5.peg.434
Escherichia coli BL21 (1-586/590)
MR
L
F
A
QL
S
W
Y
FRR
E
------
W
--------
R
R
YLG
A
VALL
VI
--
-
--IA
ML
Q
L
VP
P
KVVGIVV
DG
VTEQHF
T
TGL
I
L
M
W
I
A
TM
V
L
--
--
----
-
--
IA
VVV
Y
LLR
Y
VW
R
V
L
LFG
A
SYQ
LA
VE
LR
E
D
YYRQLS
RQ
H
P
E
F
YL
R
H
R
TG
D
L
M
A
R
A
TND
V
D
-------
R
VV
FAAGEGVL
T
L
V
-
-D
S
LV
M
G
CAV
L
I
M
M
ST
QI
SWQL
---
T
L
F
AL
L
P
M
PV
M
AI
MIKRNG
D
ALHE
RF
K
LAQ
A
AFS
S
L
ND
RTQE
S
LTS
I
--
-
-RM
I
KA
FG
-----------
LED
R
QSALFAADAEDTGKKN
M
R
VA
R
I
D
A
-
RF
DP
T
I
Y
I
AI
GM
A
N
--
LL
A
I
G
G
G
S
WMV
V
Q
GSLT
L
G
Q
LT
S
F
M
M
YLG
L
M
IW
P
M
LA
L
A
WM
FNIVERG
S
A
AY
S
R
IR
A
M
LAEA
P
V
V
N
DG
S
E
PV
PE
----
----
-
--G
RG
E
L
DV
N
IH
--
Q
FTYP
QT
D
H
PAL
E
N
V
N
F
A
L
K
P
G
QM
LGIC
G
P
TGSGKSTL
L
SLI
Q
R
H
F
D
V
S
EG
D
IR
F
HD
I
PL
TK
L
Q
L
D
S
W
R
SR
L
A
V
VSQ
T
P
F
LF
S
DTVANNIALG
-
CPNA
T
Q
Q
E
IE
H
V
AR
L
A
SVH
D
D
I
LR
L
PQ
G
Y
DT
E
V
GE
R
GV
M
LSGGQKQRI
S
IARALL
VNAE
ILILD
D
A
L
SA
V
D
GR
TE
H
Q
I
L
H
N
L
RQWG
Q
G
RT
V
I
IS
AHRLS
AL
T
E
A
S
EI
I
V
M
QH
G
H
I
AQ
RG
N
H
DE
L
A
QQS
G
W
Y
R
D
MY
R
Y
Q
QL
EAA
L
DDAPE
I
R
E
E
fig|469008.4.peg.3315
Escherichia coli BL21(DE3) (1-586/590)
MR
L
F
A
QL
S
W
Y
FRR
E
------
W
--------
R
R
YLG
A
VALL
VI
--
-
--IA
ML
Q
L
VP
P
KVVGIVV
DG
VTEQHF
T
TGL
I
L
M
W
I
A
TM
V
L
--
--
----
-
--
IA
VVV
Y
LLR
Y
VW
R
V
L
LFG
A
SYQ
LA
VE
LR
E
D
YYRQLS
RQ
H
P
E
F
YL
R
H
R
TG
D
L
M
A
R
A
TND
V
D
-------
R
VV
FAAGEGVL
T
L
V
-
-D
S
LV
M
G
CAV
L
I
M
M
ST
QI
SWQL
---
T
L
F
AL
L
P
M
PV
M
AI
MIKRNG
D
ALHE
RF
K
LAQ
A
AFS
S
L
ND
RTQE
S
LTS
I
--
-
-RM
I
KA
FG
-----------
LED
R
QSALFAADAEDTGKKN
M
R
VA
R
I
D
A
-
RF
DP
T
I
Y
I
AI
GM
A
N
--
LL
A
I
G
G
G
S
WMV
V
Q
GSLT
L
G
Q
LT
S
F
M
M
YLG
L
M
IW
P
M
LA
L
A
WM
FNIVERG
S
A
AY
S
R
IR
A
M
LAEA
P
V
V
N
DG
S
E
PV
PE
----
----
-
--G
RG
E
L
DV
N
IH
--
Q
FTYP
QT
D
H
PAL
E
N
V
N
F
A
L
K
P
G
QM
LGIC
G
P
TGSGKSTL
L
SLI
Q
R
H
F
D
V
S
EG
D
IR
F
HD
I
PL
TK
L
Q
L
D
S
W
R
SR
L
A
V
VSQ
T
P
F
LF
S
DTVANNIALG
-
CPNA
T
Q
Q
E
IE
H
V
AR
L
A
SVH
D
D
I
LR
L
PQ
G
Y
DT
E
V
GE
R
GV
M
LSGGQKQRI
S
IARALL
VNAE
ILILD
D
A
L
SA
V
D
GR
TE
H
Q
I
L
H
N
L
RQWG
Q
G
RT
V
I
IS
AHRLS
AL
T
E
A
S
EI
I
V
M
QH
G
H
I
AQ
RG
N
H
DE
L
A
QQS
G
W
Y
R
D
MY
R
Y
Q
QL
EAA
L
DDAPE
I
R
E
E
fig|595495.4.peg.421
Escherichia coli KO11 (1-586/590)
MR
L
F
A
QL
S
W
Y
FRR
E
------
W
--------
R
R
YLG
A
VALL
VI
--
-
--IA
ML
Q
L
VP
P
KVVGIVV
DG
VTEQHF
T
TGL
I
L
M
W
I
A
TM
V
L
--
--
----
-
--
IA
VVV
Y
LLR
Y
VW
R
V
L
LFG
A
SYQ
LA
VE
LR
E
D
YYRQLS
RQ
H
P
E
F
YL
R
H
R
TG
D
L
M
A
R
A
TND
V
D
-------
R
VV
FAAGEGVL
T
L
V
-
-D
S
LV
M
G
CAV
L
I
M
M
ST
QI
SWQL
---
T
L
F
AL
L
P
M
PV
M
AI
MIKRNG
D
ALHE
RF
K
LAQ
A
AFS
S
L
ND
RTQE
S
LTS
I
--
-
-RM
I
KA
FG
-----------
LED
R
QSALFAADAEDTGKKN
M
R
VA
R
I
D
A
-
RF
DP
T
I
Y
I
AI
GM
A
N
--
LL
A
I
G
G
G
S
WMV
V
Q
GSLT
L
G
Q
LT
S
F
M
M
YLG
L
M
IW
P
M
LA
L
A
WM
FNIVERG
S
A
AY
S
R
IR
A
M
LAEA
P
V
V
N
DG
S
E
PV
PE
----
----
-
--G
RG
E
L
DV
N
IH
--
Q
FTYP
QT
D
H
PAL
E
N
V
N
F
A
L
K
P
G
QM
LGIC
G
P
TGSGKSTL
L
SLI
Q
R
H
F
D
V
S
EG
D
IR
F
HD
I
PL
TK
L
Q
L
D
S
W
R
SR
L
A
V
VSQ
T
P
F
LF
S
DTVANNIALG
-
CPNA
T
Q
Q
E
IE
H
V
AR
L
A
SVH
D
D
I
LR
L
PQ
G
Y
DT
E
V
GE
R
GV
M
LSGGQKQRI
S
IARALL
VNAE
ILILD
D
A
L
SA
V
D
GR
TE
H
Q
I
L
H
N
L
RQWG
Q
G
RT
V
I
IS
AHRLS
AL
T
E
A
S
EI
I
V
M
QH
G
H
I
AQ
RG
N
H
DE
L
A
QQS
G
W
Y
R
D
MY
R
Y
Q
QL
EAA
L
DDAPE
I
R
E
E
fig|749547.3.peg.2459
Escherichia coli MS 187-1 (1-586/590)
MR
L
F
A
QL
S
W
Y
FRR
E
------
W
--------
R
R
YLG
A
VALL
VI
--
-
--IA
ML
Q
L
VP
P
KVVGIVV
DG
VTEQHF
T
TGL
I
L
M
W
I
A
TM
V
L
--
--
----
-
--
IA
VVV
Y
LLR
Y
VW
R
V
L
LFG
A
SYQ
LA
VE
LR
E
D
YYRQLS
RQ
H
P
E
F
YL
R
H
R
TG
D
L
M
A
R
A
TND
V
D
-------
R
VV
FAAGEGVL
T
L
V
-
-D
S
LV
M
G
CAV
L
I
M
M
ST
QI
SWQL
---
T
L
F
AL
L
P
M
PV
M
AI
MIKRNG
D
ALHE
RF
K
LAQ
A
AFS
S
L
ND
RTQE
S
LTS
I
--
-
-RM
I
KA
FG
-----------
LED
R
QSALFAADAEDTGKKN
M
R
VA
R
I
D
A
-
RF
DP
T
I
Y
I
AI
GM
A
N
--
LL
A
I
G
G
G
S
WMV
V
Q
GSLT
L
G
Q
LT
S
F
M
M
YLG
L
M
IW
P
M
LA
L
A
WM
FNIVERG
S
A
AY
S
R
IR
A
M
LAEA
P
V
V
N
DG
S
E
PV
PE
----
----
-
--G
RG
E
L
DV
N
IH
--
Q
FTYP
QT
D
H
PAL
E
N
V
N
F
A
L
K
P
G
QM
LGIC
G
P
TGSGKSTL
L
SLI
Q
R
H
F
D
V
S
EG
D
IR
F
HD
I
PL
TK
L
Q
L
D
S
W
R
SR
L
A
V
VSQ
T
P
F
LF
S
DTVANNIALG
-
CPNA
T
Q
Q
E
IE
H
V
AR
L
A
SVH
D
D
I
LR
L
PQ
G
Y
DT
E
V
GE
R
GV
M
LSGGQKQRI
S
IARALL
VNAE
ILILD
D
A
L
SA
V
D
GR
TE
H
Q
I
L
H
N
L
RQWG
Q
G
RT
V
I
IS
AHRLS
AL
T
E
A
S
EI
I
V
M
QH
G
H
I
AQ
RG
N
H
DE
L
A
QQS
G
W
Y
R
D
MY
R
Y
Q
QL
EAA
L
DDAPE
I
R
E
E
fig|566546.3.peg.2336
Escherichia coli W (1-586/590)
MR
L
F
A
QL
S
W
Y
FRR
E
------
W
--------
R
R
YLG
A
VALL
VI
--
-
--IA
ML
Q
L
VP
P
KVVGIVV
DG
VTEQHF
T
TGL
I
L
M
W
I
A
TM
V
L
--
--
----
-
--
IA
VVV
Y
LLR
Y
VW
R
V
L
LFG
A
SYQ
LA
VE
LR
E
D
YYRQLS
RQ
H
P
E
F
YL
R
H
R
TG
D
L
M
A
R
A
TND
V
D
-------
R
VV
FAAGEGVL
T
L
V
-
-D
S
LV
M
G
CAV
L
I
M
M
ST
QI
SWQL
---
T
L
F
AL
L
P
M
PV
M
AI
MIKRNG
D
ALHE
RF
K
LAQ
A
AFS
S
L
ND
RTQE
S
LTS
I
--
-
-RM
I
KA
FG
-----------
LED
R
QSALFAADAEDTGKKN
M
R
VA
R
I
D
A
-
RF
DP
T
I
Y
I
AI
GM
A
N
--
LL
A
I
G
G
G
S
WMV
V
Q
GSLT
L
G
Q
LT
S
F
M
M
YLG
L
M
IW
P
M
LA
L
A
WM
FNIVERG
S
A
AY
S
R
IR
A
M
LAEA
P
V
V
N
DG
S
E
PV
PE
----
----
-
--G
RG
E
L
DV
N
IH
--
Q
FTYP
QT
D
H
PAL
E
N
V
N
F
A
L
K
P
G
QM
LGIC
G
P
TGSGKSTL
L
SLI
Q
R
H
F
D
V
S
EG
D
IR
F
HD
I
PL
TK
L
Q
L
D
S
W
R
SR
L
A
V
VSQ
T
P
F
LF
S
DTVANNIALG
-
CPNA
T
Q
Q
E
IE
H
V
AR
L
A
SVH
D
D
I
LR
L
PQ
G
Y
DT
E
V
GE
R
GV
M
LSGGQKQRI
S
IARALL
VNAE
ILILD
D
A
L
SA
V
D
GR
TE
H
Q
I
L
H
N
L
RQWG
Q
G
RT
V
I
IS
AHRLS
AL
T
E
A
S
EI
I
V
M
QH
G
H
I
AQ
RG
N
H
DE
L
A
QQS
G
W
Y
R
D
MY
R
Y
Q
QL
EAA
L
DDAPE
I
R
E
E
fig|566546.4.peg.525
Escherichia coli W (1-586/590)
MR
L
F
A
QL
S
W
Y
FRR
E
------
W
--------
R
R
YLG
A
VALL
VI
--
-
--IA
ML
Q
L
VP
P
KVVGIVV
DG
VTEQHF
T
TGL
I
L
M
W
I
A
TM
V
L
--
--
----
-
--
IA
VVV
Y
LLR
Y
VW
R
V
L
LFG
A
SYQ
LA
VE
LR
E
D
YYRQLS
RQ
H
P
E
F
YL
R
H
R
TG
D
L
M
A
R
A
TND
V
D
-------
R
VV
FAAGEGVL
T
L
V
-
-D
S
LV
M
G
CAV
L
I
M
M
ST
QI
SWQL
---
T
L
F
AL
L
P
M
PV
M
AI
MIKRNG
D
ALHE
RF
K
LAQ
A
AFS
S
L
ND
RTQE
S
LTS
I
--
-
-RM
I
KA
FG
-----------
LED
R
QSALFAADAEDTGKKN
M
R
VA
R
I
D
A
-
RF
DP
T
I
Y
I
AI
GM
A
N
--
LL
A
I
G
G
G
S
WMV
V
Q
GSLT
L
G
Q
LT
S
F
M
M
YLG
L
M
IW
P
M
LA
L
A
WM
FNIVERG
S
A
AY
S
R
IR
A
M
LAEA
P
V
V
N
DG
S
E
PV
PE
----
----
-
--G
RG
E
L
DV
N
IH
--
Q
FTYP
QT
D
H
PAL
E
N
V
N
F
A
L
K
P
G
QM
LGIC
G
P
TGSGKSTL
L
SLI
Q
R
H
F
D
V
S
EG
D
IR
F
HD
I
PL
TK
L
Q
L
D
S
W
R
SR
L
A
V
VSQ
T
P
F
LF
S
DTVANNIALG
-
CPNA
T
Q
Q
E
IE
H
V
AR
L
A
SVH
D
D
I
LR
L
PQ
G
Y
DT
E
V
GE
R
GV
M
LSGGQKQRI
S
IARALL
VNAE
ILILD
D
A
L
SA
V
D
GR
TE
H
Q
I
L
H
N
L
RQWG
Q
G
RT
V
I
IS
AHRLS
AL
T
E
A
S
EI
I
V
M
QH
G
H
I
AQ
RG
N
H
DE
L
A
QQS
G
W
Y
R
D
MY
R
Y
Q
QL
EAA
L
DDAPE
I
R
E
E
fig|216593.1.peg.3152
Escherichia coli E2348/69 (1-586/590)
MR
L
F
A
QL
S
W
Y
FRR
E
------
W
--------
R
R
YLG
A
VALL
VI
--
-
--IA
ML
Q
L
VP
P
KVVGIVV
DG
VTEQHF
T
TGQ
I
L
M
W
I
A
TM
V
L
--
--
----
-
--
IA
VVV
Y
LLR
Y
VW
R
V
L
LFG
A
SYQ
LA
VE
LR
E
D
YYRQLS
RQ
H
P
E
F
YL
R
H
R
TG
D
L
M
A
R
A
TND
V
D
-------
R
VV
FAAGEGVL
T
L
V
-
-D
S
LV
M
G
CAV
L
I
M
M
ST
QI
SWQL
---
T
L
F
AL
L
P
M
PV
M
AI
MIKRNG
D
ALHE
RF
K
LAQ
A
AFS
S
L
ND
RTQE
S
LTS
I
--
-
-RM
I
KA
FG
-----------
LED
R
QSALFAADAEDTGKKN
M
R
VA
R
I
D
A
-
RF
DP
T
I
Y
I
AI
GM
A
N
--
LL
A
I
G
G
G
S
WMV
V
Q
GSLT
L
G
Q
LT
S
F
M
M
YLG
L
M
IW
P
M
LA
L
A
WM
FNIVERG
S
A
AY
S
R
IR
T
M
LAEA
P
V
V
I
DG
S
D
KV
PE
----
----
-
--G
RG
E
L
DV
N
IR
--
Q
FTYP
QT
D
H
PAL
E
N
V
N
F
A
L
K
P
G
QM
V
GIC
G
P
TGSGKSTL
L
SLI
Q
R
H
F
D
V
S
EG
D
IR
F
HD
I
PL
TK
L
Q
L
D
S
W
R
SR
L
A
V
VSQ
T
P
F
LF
S
DTVANNIALG
-
CPNA
T
Q
Q
E
IE
H
V
AR
L
A
SVH
D
D
I
LR
L
PQ
G
Y
DT
E
V
GE
R
GV
M
LSGGQKQRI
S
IARALL
VNAE
ILILD
D
A
L
SA
V
D
GR
TE
H
Q
I
L
H
N
L
RQWG
Q
G
RT
V
I
IS
AHRLS
AL
T
E
A
S
EI
I
V
M
QH
G
H
I
AQ
C
G
N
H
DE
L
A
QQS
G
W
Y
R
D
MY
R
Y
Q
QL
EAA
L
DDAPE
I
R
E
E
fig|749531.3.peg.2799
Escherichia coli MS 69-1 (1-586/590)
MR
L
F
A
QL
S
W
Y
FRR
E
------
W
--------
R
R
YLG
A
VALL
VI
--
-
--IA
ML
Q
L
VP
P
KVVGIVV
DG
VTEQHF
T
TGQ
I
L
M
W
I
A
TM
V
L
--
--
----
-
--
IA
VVV
Y
LLR
Y
VW
R
V
L
LFG
A
SYQ
LA
VE
LR
E
D
YYRQLS
RQ
H
P
E
F
YL
R
H
R
TG
D
L
M
A
R
A
TND
V
D
-------
R
VV
FAAGEGVL
T
L
V
-
-D
S
LV
M
G
CAV
L
I
M
M
ST
QI
SWQL
---
T
L
F
AL
L
P
M
PV
M
AI
MIKRNG
D
ALHE
RF
K
LAQ
A
AFS
S
L
ND
RTQE
S
LTS
I
--
-
-RM
I
KA
FG
-----------
LED
R
QSALFAEDAEDTGKKN
M
R
VA
R
I
D
A
-
RF
DP
T
I
Y
I
AI
G
T
A
N
--
LL
A
I
G
G
G
S
WMV
V
Q
GSLT
L
G
Q
LT
S
F
M
M
YLG
L
M
IW
P
M
LA
L
A
WM
FNIVERG
S
A
AY
S
R
IR
A
M
LAEA
P
V
V
N
DG
S
E
PV
PE
----
----
-
--G
RG
E
L
DV
N
IR
--
Q
FTYP
QT
D
H
PAL
E
N
V
N
F
A
L
K
P
G
QM
LGIC
G
P
TGSGKSTL
L
SLI
Q
R
H
F
D
V
S
EG
D
IR
F
H
Y
I
PL
TK
L
Q
L
D
S
W
R
SR
L
A
V
VSQ
T
P
F
LF
S
DTVANNIALG
-
CPNA
T
Q
Q
E
IE
H
V
AR
L
A
SVH
D
D
I
LR
L
PQ
G
Y
DT
E
V
GE
R
GV
M
LSGGQKQRI
S
IARALL
VNAE
ILILD
D
A
L
SA
V
D
GR
TE
H
Q
I
L
H
N
L
RQWG
Q
G
RT
V
I
IS
AHRLS
AL
T
E
A
S
EI
I
V
M
QH
G
H
I
AQ
RG
N
H
DE
L
A
QQS
G
W
Y
R
D
MY
R
Y
Q
QL
EAA
L
DDAPE
I
R
E
E
fig|216592.1.peg.4767
Escherichia coli 042 (1-586/590)
MR
L
F
A
QL
S
W
Y
FRR
E
------
W
--------
R
R
YLG
A
VALL
VI
--
-
--IA
ML
Q
L
VP
P
KVVGIVV
DG
VTEQHF
T
TGQ
I
L
M
W
I
A
TM
V
L
--
--
----
-
--
IA
VVV
Y
LLR
Y
VW
R
V
L
LFG
A
SYQ
LA
VE
LR
E
D
YYRQLS
RQ
H
P
E
F
YL
R
H
R
TG
D
L
M
A
R
A
TND
V
D
-------
R
VV
FAAGEGVL
T
L
V
-
-D
S
LV
M
G
CAV
L
I
VM
ST
QI
SWQL
---
T
L
L
AL
V
P
M
P
IM
A
L
VIKRNG
D
ALHE
RF
K
LAQ
A
AFS
S
L
ND
RTQE
S
LTS
I
--
-
-RM
I
KA
FG
-----------
LED
R
QSALFAADAEDTGKKN
M
R
VA
R
I
D
A
-
RF
DP
T
I
Y
I
AI
GM
A
N
--
LL
A
I
G
G
G
S
WMV
V
Q
GSLT
L
G
Q
LT
S
F
M
M
YLG
L
M
IW
P
M
LA
L
A
WM
FNIVERG
S
A
AY
S
R
IR
A
M
LAEA
P
V
V
N
DG
S
E
PV
PE
----
----
-
--G
RG
E
L
DV
N
IR
--
Q
FTYP
QT
D
H
PAL
E
N
V
N
F
A
L
K
P
G
QM
LGIC
G
P
TGSGKSTL
L
SLI
Q
R
H
F
D
V
S
EG
D
IR
F
HD
I
PL
TK
L
Q
L
D
S
W
R
SR
L
A
V
VSQ
T
P
F
LF
S
DTVANNIALG
-
CPNA
T
Q
Q
E
IE
H
V
AR
L
A
SVH
D
D
I
LR
L
PQ
G
Y
DT
E
V
GE
R
GV
M
LSGGQKQRI
S
IARALL
VNAE
ILILD
D
A
L
SA
V
D
GR
TE
H
Q
I
L
H
N
L
RQWG
Q
G
RT
V
I
IS
AHRLS
AL
T
E
A
S
EI
I
V
M
QH
G
H
I
AQ
RG
N
H
DE
L
A
QQS
G
W
Y
R
D
MY
R
Y
Q
QL
EAA
L
N
DAPE
I
R
E
E
fig|216592.3.peg.510
Escherichia coli 042 (1-586/590)
MR
L
F
A
QL
S
W
Y
FRR
E
------
W
--------
R
R
YLG
A
VALL
VI
--
-
--IA
ML
Q
L
VP
P
KVVGIVV
DG
VTEQHF
T
TGQ
I
L
M
W
I
A
TM
V
L
--
--
----
-
--
IA
VVV
Y
LLR
Y
VW
R
V
L
LFG
A
SYQ
LA
VE
LR
E
D
YYRQLS
RQ
H
P
E
F
YL
R
H
R
TG
D
L
M
A
R
A
TND
V
D
-------
R
VV
FAAGEGVL
T
L
V
-
-D
S
LV
M
G
CAV
L
I
VM
ST
QI
SWQL
---
T
L
L
AL
V
P
M
P
IM
A
L
VIKRNG
D
ALHE
RF
K
LAQ
A
AFS
S
L
ND
RTQE
S
LTS
I
--
-
-RM
I
KA
FG
-----------
LED
R
QSALFAADAEDTGKKN
M
R
VA
R
I
D
A
-
RF
DP
T
I
Y
I
AI
GM
A
N
--
LL
A
I
G
G
G
S
WMV
V
Q
GSLT
L
G
Q
LT
S
F
M
M
YLG
L
M
IW
P
M
LA
L
A
WM
FNIVERG
S
A
AY
S
R
IR
A
M
LAEA
P
V
V
N
DG
S
E
PV
PE
----
----
-
--G
RG
E
L
DV
N
IR
--
Q
FTYP
QT
D
H
PAL
E
N
V
N
F
A
L
K
P
G
QM
LGIC
G
P
TGSGKSTL
L
SLI
Q
R
H
F
D
V
S
EG
D
IR
F
HD
I
PL
TK
L
Q
L
D
S
W
R
SR
L
A
V
VSQ
T
P
F
LF
S
DTVANNIALG
-
CPNA
T
Q
Q
E
IE
H
V
AR
L
A
SVH
D
D
I
LR
L
PQ
G
Y
DT
E
V
GE
R
GV
M
LSGGQKQRI
S
IARALL
VNAE
ILILD
D
A
L
SA
V
D
GR
TE
H
Q
I
L
H
N
L
RQWG
Q
G
RT
V
I
IS
AHRLS
AL
T
E
A
S
EI
I
V
M
QH
G
H
I
AQ
RG
N
H
DE
L
A
QQS
G
W
Y
R
D
MY
R
Y
Q
QL
EAA
L
N
DAPE
I
R
E
E
fig|656437.3.peg.533
Escherichia coli TA143 (1-586/590)
MR
L
F
A
QL
S
W
Y
FRR
E
------
W
--------
R
R
YLG
A
VALL
VI
--
-
--IA
ML
Q
L
VP
P
KVVGIVV
DG
VTEQHF
T
TGQ
I
L
M
W
I
A
TM
V
L
--
--
----
-
--
IA
VVV
Y
LLR
Y
VW
R
V
L
LFG
A
SYQ
LA
VE
LR
E
D
YYRQLS
RQ
H
P
E
F
YL
R
H
R
TG
D
L
M
A
R
A
TND
V
D
-------
R
VV
FAAGEGVL
T
L
V
-
-D
S
LV
M
G
CAV
L
I
VM
ST
QI
SWQL
---
T
L
L
AL
V
P
M
P
IM
A
L
VIKRNG
D
ALHE
RF
K
LAQ
A
AFS
S
L
ND
RTQE
S
LTS
I
--
-
-RM
I
KA
FG
-----------
LED
R
QSALFAADAEDTGKKN
M
R
VA
R
I
D
A
-
RF
DP
T
I
Y
I
AI
GM
A
N
--
LL
A
I
G
G
G
S
WMV
V
Q
GSLT
L
G
Q
LT
S
F
M
M
YLG
L
M
IW
P
M
LA
L
A
WM
FNIVERG
S
A
AY
S
R
IR
A
M
LAEA
P
V
V
N
DG
S
E
PV
PE
----
----
-
--G
RG
E
L
DV
N
IR
--
Q
FTYP
QT
D
H
PAL
E
N
V
N
F
A
L
K
P
G
QM
LGIC
G
P
TGSGKSTL
L
SLI
Q
R
H
F
D
V
S
EG
D
IR
F
HD
I
PL
TK
L
Q
L
D
S
W
R
SR
L
A
V
VSQ
T
P
F
LF
S
DTVANNIALG
-
CPNA
T
Q
Q
E
IE
H
V
AR
L
A
SVH
D
D
I
LR
L
PQ
G
Y
DT
E
V
GE
R
GV
M
LSGGQKQRI
S
IARALL
VNAE
ILILD
D
A
L
SA
V
D
GR
TE
H
Q
I
L
H
N
L
RQWG
Q
G
RT
V
I
IS
AHRLS
AL
T
E
A
S
EI
I
V
M
QH
G
H
I
AQ
RG
N
H
DE
L
A
QQS
G
W
Y
R
D
MY
R
Y
Q
QL
EAA
L
N
DAPE
I
R
E
E
fig|656417.3.peg.591
Escherichia coli M605 (1-586/590)
MR
L
F
A
QL
S
W
Y
FRR
E
------
W
--------
R
R
YLG
A
VALL
VI
--
-
--IA
ML
Q
L
VP
P
KVVGIVV
DG
VTEQHF
T
TGQ
I
L
M
W
I
A
TM
V
L
--
--
----
-
--
IA
VVV
Y
LLR
Y
VW
R
V
L
LFG
A
SYQ
LA
VE
LR
E
D
YYRQLS
RQ
H
P
E
F
YL
R
H
R
TG
D
L
M
A
R
A
TND
V
D
-------
R
VV
FAAGEGVL
T
L
V
-
-D
S
LV
M
G
CAV
L
I
M
M
ST
QI
SWQL
---
T
L
F
AL
L
P
M
PV
M
AI
MIKRNG
D
ALHE
RF
K
LAQ
A
AFS
S
L
ND
RTQE
S
LTS
I
--
-
-RM
I
KA
FG
-----------
LED
R
QSALFAADAEDTGKKN
M
R
VA
R
I
D
A
-
RF
DP
T
I
Y
I
AI
GM
A
N
--
LL
A
I
G
G
G
S
WMV
V
Q
GSLT
L
G
Q
LT
S
F
M
M
YLG
L
M
IW
P
M
LA
L
A
WM
FNIVERG
S
A
AY
S
R
IR
T
M
LAEA
P
V
V
I
DG
S
D
KV
PE
----
----
-
--G
RG
E
L
DV
N
IR
--
Q
FTYP
QT
D
H
PAL
E
N
V
N
F
A
L
K
P
G
QM
LGIC
G
P
TGSGKSTL
L
SLI
Q
R
H
F
D
V
S
EG
D
IR
F
HD
I
PL
TK
L
Q
L
D
S
W
R
SR
L
A
V
VSQ
T
P
F
LF
S
DTVANNIALG
-
CPNA
T
Q
Q
E
IE
H
V
AR
L
A
SVH
D
D
I
LR
L
PQ
G
Y
DT
E
V
GE
R
GV
M
LSGGQKQRI
S
IARALL
VNAE
ILILD
D
A
L
SA
V
D
GR
TE
H
Q
I
L
H
N
L
RQWG
Q
G
RT
V
I
IS
AHRLS
AL
T
E
A
S
EI
I
V
M
QH
G
H
I
AQ
RG
N
H
DV
L
V
QQS
G
W
Y
R
D
MY
R
Y
Q
QL
EAA
L
DDAPE
I
R
E
E
fig|340184.3.peg.3337
Escherichia coli B7A (1-586/590)
MR
L
F
A
QL
S
W
Y
FRR
E
------
W
--------
R
R
YLG
A
VALL
VI
--
-
--IA
ML
Q
L
VP
P
KVVGIVV
DG
VTEQHF
T
TGQ
I
L
M
W
I
A
TM
V
L
--
--
----
-
--
IA
VVV
Y
FLR
Y
VW
R
V
L
LFG
A
SYQ
LA
VE
LR
E
D
YYRQLS
RQ
H
P
E
F
YL
R
H
R
TG
D
L
M
A
R
A
TND
V
D
-------
R
VV
FAAGEGVL
T
L
V
-
-D
S
LV
M
G
CAV
L
I
M
M
ST
QI
SWQL
---
T
L
F
AL
L
P
M
PV
M
AI
MIKRNG
D
ALHE
RF
K
LAQ
A
AFS
S
L
ND
RTQE
S
LTS
I
--
-
-RM
I
KA
FG
-----------
LED
R
QSALFAADAEDTGKKN
M
R
VA
R
I
D
A
-
RF
DP
T
I
Y
I
AI
GM
A
N
--
LL
A
I
G
G
G
S
WMV
V
Q
GSLT
L
G
Q
LT
S
F
M
M
YLG
L
M
IW
P
M
LA
L
A
WM
FNIVERG
S
A
AY
S
R
IR
A
M
LAEA
P
V
V
N
DG
S
E
PV
PE
----
----
-
--G
RG
E
L
DV
N
IH
--
Q
FTYP
QT
D
H
PAL
E
N
V
N
F
A
L
K
P
G
QM
LGIC
G
P
TGSGKSTL
L
SLI
Q
R
H
F
D
V
S
EG
D
IR
F
HD
I
PL
TK
L
Q
L
D
S
W
R
SR
L
A
V
VSQ
T
P
F
LF
S
DTVANNIALG
-
CPNA
T
Q
Q
E
IE
H
V
AR
L
A
SVH
D
D
I
LR
L
PQ
G
Y
DT
E
V
GE
R
GV
M
LSGGQKQRI
S
IARALL
VNAE
ILILD
D
A
L
SA
V
D
GR
TE
H
Q
I
L
H
N
L
RQWG
Q
G
RT
V
I
IS
AHRLS
AL
T
E
A
S
EI
I
V
M
QH
G
H
I
AQ
RG
N
H
DE
L
A
QQS
G
W
Y
R
D
MY
R
Y
Q
QL
EAA
L
DDAPE
I
R
E
E
fig|340184.6.peg.3483
Escherichia coli B7A (1-586/590)
MR
L
F
A
QL
S
W
Y
FRR
E
------
W
--------
R
R
YLG
A
VALL
VI
--
-
--IA
ML
Q
L
VP
P
KVVGIVV
DG
VTEQHF
T
TGQ
I
L
M
W
I
A
TM
V
L
--
--
----
-
--
IA
VVV
Y
FLR
Y
VW
R
V
L
LFG
A
SYQ
LA
VE
LR
E
D
YYRQLS
RQ
H
P
E
F
YL
R
H
R
TG
D
L
M
A
R
A
TND
V
D
-------
R
VV
FAAGEGVL
T
L
V
-
-D
S
LV
M
G
CAV
L
I
M
M
ST
QI
SWQL
---
T
L
F
AL
L
P
M
PV
M
AI
MIKRNG
D
ALHE
RF
K
LAQ
A
AFS
S
L
ND
RTQE
S
LTS
I
--
-
-RM
I
KA
FG
-----------
LED
R
QSALFAADAEDTGKKN
M
R
VA
R
I
D
A
-
RF
DP
T
I
Y
I
AI
GM
A
N
--
LL
A
I
G
G
G
S
WMV
V
Q
GSLT
L
G
Q
LT
S
F
M
M
YLG
L
M
IW
P
M
LA
L
A
WM
FNIVERG
S
A
AY
S
R
IR
A
M
LAEA
P
V
V
N
DG
S
E
PV
PE
----
----
-
--G
RG
E
L
DV
N
IH
--
Q
FTYP
QT
D
H
PAL
E
N
V
N
F
A
L
K
P
G
QM
LGIC
G
P
TGSGKSTL
L
SLI
Q
R
H
F
D
V
S
EG
D
IR
F
HD
I
PL
TK
L
Q
L
D
S
W
R
SR
L
A
V
VSQ
T
P
F
LF
S
DTVANNIALG
-
CPNA
T
Q
Q
E
IE
H
V
AR
L
A
SVH
D
D
I
LR
L
PQ
G
Y
DT
E
V
GE
R
GV
M
LSGGQKQRI
S
IARALL
VNAE
ILILD
D
A
L
SA
V
D
GR
TE
H
Q
I
L
H
N
L
RQWG
Q
G
RT
V
I
IS
AHRLS
AL
T
E
A
S
EI
I
V
M
QH
G
H
I
AQ
RG
N
H
DE
L
A
QQS
G
W
Y
R
D
MY
R
Y
Q
QL
EAA
L
DDAPE
I
R
E
E
fig|331111.12.peg.792
Escherichia coli E24377A (1-586/590)
MR
L
F
A
QL
S
W
Y
FRR
E
------
W
--------
R
R
YLG
A
VALL
VI
--
-
--IA
ML
Q
L
VP
P
KVVGIVV
DG
VTEQHF
T
TGQ
I
L
M
W
I
A
TM
V
L
--
--
----
-
--
IA
VVV
Y
FLR
Y
VW
R
V
L
LFG
A
SYQ
LA
VE
LR
E
D
YYRQLS
RQ
H
P
E
F
YL
R
H
R
TG
D
L
M
A
R
A
TND
V
D
-------
R
VV
FAAGEGVL
T
L
V
-
-D
S
LV
M
G
CAV
L
I
M
M
ST
QI
SWQL
---
T
L
F
AL
L
P
M
PV
M
AI
MIKRNG
D
ALHE
RF
K
LAQ
A
AFS
S
L
ND
RTQE
S
LTS
I
--
-
-RM
I
KA
FG
-----------
LED
R
QSALFAADAEDTGKKN
M
R
VA
R
I
D
A
-
RF
DP
T
I
Y
I
AI
GM
A
N
--
LL
A
I
G
G
G
S
WMV
V
Q
GSLT
L
G
Q
LT
S
F
M
M
YLG
L
M
IW
P
M
LA
L
A
WM
FNIVERG
S
A
AY
S
R
IR
A
M
LAEA
P
V
V
N
DG
S
E
PV
PE
----
----
-
--G
RG
E
L
DV
N
IH
--
Q
FTYP
QT
D
H
PAL
E
N
V
N
F
A
L
K
P
G
QM
LGIC
G
P
TGSGKSTL
L
SLI
Q
R
H
F
D
V
S
EG
D
IR
F
HD
I
PL
TK
L
Q
L
D
S
W
R
SR
L
A
V
VSQ
T
P
F
LF
S
DTVANNIALG
-
CPNA
T
Q
Q
E
IE
H
V
AR
L
A
SVH
D
D
I
LR
L
PQ
G
Y
DT
E
V
GE
R
GV
M
LSGGQKQRI
S
IARALL
VNAE
ILILD
D
A
L
SA
V
D
GR
TE
H
Q
I
L
H
N
L
RQWG
Q
G
RT
V
I
IS
AHRLS
AL
T
E
A
S
EI
I
V
M
QH
G
H
I
AQ
RG
N
H
DE
L
A
QQS
G
W
Y
R
D
MY
R
Y
Q
QL
EAA
L
DDAPE
I
R
E
E
fig|331111.3.peg.3023
Escherichia coli E24377A (1-586/590)
MR
L
F
A
QL
S
W
Y
FRR
E
------
W
--------
R
R
YLG
A
VALL
VI
--
-
--IA
ML
Q
L
VP
P
KVVGIVV
DG
VTEQHF
T
TGQ
I
L
M
W
I
A
TM
V
L
--
--
----
-
--
IA
VVV
Y
FLR
Y
VW
R
V
L
LFG
A
SYQ
LA
VE
LR
E
D
YYRQLS
RQ
H
P
E
F
YL
R
H
R
TG
D
L
M
A
R
A
TND
V
D
-------
R
VV
FAAGEGVL
T
L
V
-
-D
S
LV
M
G
CAV
L
I
M
M
ST
QI
SWQL
---
T
L
F
AL
L
P
M
PV
M
AI
MIKRNG
D
ALHE
RF
K
LAQ
A
AFS
S
L
ND
RTQE
S
LTS
I
--
-
-RM
I
KA
FG
-----------
LED
R
QSALFAADAEDTGKKN
M
R
VA
R
I
D
A
-
RF
DP
T
I
Y
I
AI
GM
A
N
--
LL
A
I
G
G
G
S
WMV
V
Q
GSLT
L
G
Q
LT
S
F
M
M
YLG
L
M
IW
P
M
LA
L
A
WM
FNIVERG
S
A
AY
S
R
IR
A
M
LAEA
P
V
V
N
DG
S
E
PV
PE
----
----
-
--G
RG
E
L
DV
N
IH
--
Q
FTYP
QT
D
H
PAL
E
N
V
N
F
A
L
K
P
G
QM
LGIC
G
P
TGSGKSTL
L
SLI
Q
R
H
F
D
V
S
EG
D
IR
F
HD
I
PL
TK
L
Q
L
D
S
W
R
SR
L
A
V
VSQ
T
P
F
LF
S
DTVANNIALG
-
CPNA
T
Q
Q
E
IE
H
V
AR
L
A
SVH
D
D
I
LR
L
PQ
G
Y
DT
E
V
GE
R
GV
M
LSGGQKQRI
S
IARALL
VNAE
ILILD
D
A
L
SA
V
D
GR
TE
H
Q
I
L
H
N
L
RQWG
Q
G
RT
V
I
IS
AHRLS
AL
T
E
A
S
EI
I
V
M
QH
G
H
I
AQ
RG
N
H
DE
L
A
QQS
G
W
Y
R
D
MY
R
Y
Q
QL
EAA
L
DDAPE
I
R
E
E
fig|679204.3.peg.1953
Escherichia coli MS 145-7 (1-586/590)
MR
L
F
A
QL
S
W
Y
FRR
E
------
W
--------
R
R
YLG
A
VALL
VI
--
-
--IA
ML
Q
L
VP
P
KVVGIVV
DG
VTEQHF
T
TGQ
I
L
M
W
I
A
TM
V
L
--
--
----
-
--
IA
VVV
Y
FLR
Y
VW
R
V
L
LFG
A
SYQ
LA
VE
LR
E
D
YYRQLS
RQ
H
P
E
F
YL
R
H
R
TG
D
L
M
A
R
A
TND
V
D
-------
R
VV
FAAGEGVL
T
L
V
-
-D
S
LV
M
G
CAV
L
I
M
M
ST
QI
SWQL
---
T
L
F
AL
L
P
M
PV
M
AI
MIKRNG
D
ALHE
RF
K
LAQ
A
AFS
S
L
ND
RTQE
S
LTS
I
--
-
-RM
I
KA
FG
-----------
LED
R
QSALFAADAEDTGKKN
M
R
VA
R
I
D
A
-
RF
DP
T
I
Y
I
AI
GM
A
N
--
LL
A
I
G
G
G
S
WMV
V
Q
GSLT
L
G
Q
LT
S
F
M
M
YLG
L
M
IW
P
M
LA
L
A
WM
FNIVERG
S
A
AY
S
R
IR
A
M
LAEA
P
V
V
N
DG
S
E
PV
PE
----
----
-
--G
RG
E
L
DV
N
IH
--
Q
FTYP
QT
D
H
PAL
E
N
V
N
F
A
L
K
P
G
QM
LGIC
G
P
TGSGKSTL
L
SLI
Q
R
H
F
D
V
S
EG
D
IR
F
HD
I
PL
TK
L
Q
L
D
S
W
R
SR
L
A
V
VSQ
T
P
F
LF
S
DTVANNIALG
-
CPNA
T
Q
Q
E
IE
H
V
AR
L
A
SVH
D
D
I
LR
L
PQ
G
Y
DT
E
V
GE
R
GV
M
LSGGQKQRI
S
IARALL
VNAE
ILILD
D
A
L
SA
V
D
GR
TE
H
Q
I
L
H
N
L
RQWG
Q
G
RT
V
I
IS
AHRLS
AL
T
E
A
S
EI
I
V
M
QH
G
H
I
AQ
RG
N
H
DE
L
A
QQS
G
W
Y
R
D
MY
R
Y
Q
QL
EAA
L
DDAPE
I
R
E
E
fig|1040638.4.peg.5141
Escherichia coli O104:H4 str. LB226692 (1-586/590)
MR
L
F
A
QL
S
W
Y
FRR
E
------
W
--------
R
R
YLG
A
VALL
VI
--
-
--IA
ML
Q
L
VP
P
KVVGIVV
DG
VTEQHF
T
TGQ
I
L
M
W
I
A
TM
V
L
--
--
----
-
--
IA
VVV
Y
LLR
Y
VW
R
V
L
LFG
A
SYQ
LA
VE
LR
E
D
YYRQLS
RQ
H
P
E
F
YL
R
H
R
TG
D
L
M
A
R
A
TND
V
D
-------
R
VV
FAAGEGVL
T
L
V
-
-D
S
LV
M
G
CAV
L
I
M
M
ST
QI
SWQL
---
T
L
F
AL
L
P
M
PV
M
AI
MIKRNG
D
ALHE
RF
K
LAQ
A
AFS
S
L
ND
RTQE
S
LTS
I
--
-
-RM
I
KA
FG
-----------
LED
R
QSALFAADAEDTGKKN
M
R
VA
R
I
D
A
-
RF
DP
T
I
Y
I
AI
GM
A
N
--
LL
A
I
G
G
G
S
WMV
A
Q
GSLT
L
G
Q
LT
S
F
M
M
YLG
L
M
IW
P
M
LA
L
A
WM
FNIVERG
S
A
AY
S
R
IR
A
M
LAEA
P
V
V
N
DG
S
E
PV
PE
----
----
-
--G
RG
E
L
DV
N
IH
--
Q
FTYP
QT
D
H
PAL
E
N
V
N
F
A
L
K
P
G
QM
LGIC
G
P
TGSGKSTL
L
SLI
Q
R
H
F
D
V
S
EG
D
IR
F
HD
I
PL
TK
L
Q
L
D
S
W
R
SR
L
A
V
VSQ
T
P
F
LF
S
DTVANNIALG
-
CPNA
T
Q
Q
E
IE
H
V
AR
L
A
SVH
D
D
I
LR
L
PQ
G
Y
DT
E
V
GE
R
GV
M
LSGGQKQRI
S
IARALL
VNAE
ILILD
D
A
L
SA
V
D
GR
TE
H
Q
I
L
H
N
L
RQWG
Q
G
RT
V
I
IS
AHRLS
AL
T
E
A
S
EI
I
V
M
QH
G
H
I
AQ
RG
N
H
DE
L
A
QQS
G
W
Y
R
D
MY
R
Y
Q
QL
EAA
L
DD
V
PE
I
R
E
E
fig|6666666.5357.peg.1400
Escherichia coli TY-2482 (1-586/590)
MR
L
F
A
QL
S
W
Y
FRR
E
------
W
--------
R
R
YLG
A
VALL
VI
--
-
--IA
ML
Q
L
VP
P
KVVGIVV
DG
VTEQHF
T
TGQ
I
L
M
W
I
A
TM
V
L
--
--
----
-
--
IA
VVV
Y
LLR
Y
VW
R
V
L
LFG
A
SYQ
LA
VE
LR
E
D
YYRQLS
RQ
H
P
E
F
YL
R
H
R
TG
D
L
M
A
R
A
TND
V
D
-------
R
VV
FAAGEGVL
T
L
V
-
-D
S
LV
M
G
CAV
L
I
M
M
ST
QI
SWQL
---
T
L
F
AL
L
P
M
PV
M
AI
MIKRNG
D
ALHE
RF
K
LAQ
A
AFS
S
L
ND
RTQE
S
LTS
I
--
-
-RM
I
KA
FG
-----------
LED
R
QSALFAADAEDTGKKN
M
R
VA
R
I
D
A
-
RF
DP
T
I
Y
I
AI
GM
A
N
--
LL
A
I
G
G
G
S
WMV
A
Q
GSLT
L
G
Q
LT
S
F
M
M
YLG
L
M
IW
P
M
LA
L
A
WM
FNIVERG
S
A
AY
S
R
IR
A
M
LAEA
P
V
V
N
DG
S
E
PV
PE
----
----
-
--G
RG
E
L
DV
N
IH
--
Q
FTYP
QT
D
H
PAL
E
N
V
N
F
A
L
K
P
G
QM
LGIC
G
P
TGSGKSTL
L
SLI
Q
R
H
F
D
V
S
EG
D
IR
F
HD
I
PL
TK
L
Q
L
D
S
W
R
SR
L
A
V
VSQ
T
P
F
LF
S
DTVANNIALG
-
CPNA
T
Q
Q
E
IE
H
V
AR
L
A
SVH
D
D
I
LR
L
PQ
G
Y
DT
E
V
GE
R
GV
M
LSGGQKQRI
S
IARALL
VNAE
ILILD
D
A
L
SA
V
D
GR
TE
H
Q
I
L
H
N
L
RQWG
Q
G
RT
V
I
IS
AHRLS
AL
T
E
A
S
EI
I
V
M
QH
G
H
I
AQ
RG
N
H
DE
L
A
QQS
G
W
Y
R
D
MY
R
Y
Q
QL
EAA
L
DD
V
PE
I
R
E
E
fig|585055.6.peg.470
Escherichia coli 55989 (1-586/590)
MR
L
F
A
QL
S
W
Y
FRR
E
------
W
--------
R
R
YLG
A
VALL
VI
--
-
--IA
ML
Q
L
VP
P
KVVGIVV
DG
VTEQHF
T
TGQ
I
L
M
W
I
A
TM
V
L
--
--
----
-
--
IA
VVV
Y
LLR
Y
VW
R
V
L
LFG
A
SYQ
LA
VE
LR
E
D
YYRQLS
RQ
H
P
E
F
YL
R
H
R
TG
D
L
M
A
R
A
TND
V
D
-------
R
VV
FAAGEGVL
T
L
V
-
-D
S
LV
M
G
CAV
L
I
M
M
ST
QI
SWQL
---
T
L
F
AL
L
P
M
PV
M
AI
MIKRNG
D
ALHE
RF
K
LAQ
A
AFS
S
L
ND
RTQE
S
LTS
I
--
-
-RM
I
KA
FG
-----------
LED
R
QSALFAADAEDTGKKN
M
R
VA
R
I
D
A
-
RF
DP
T
I
Y
I
AI
GM
A
N
--
LL
A
I
G
G
G
S
WMV
A
Q
GSLT
L
G
Q
LT
S
F
M
M
YLG
L
M
IW
P
M
LA
L
A
WM
FNIVERG
S
A
AY
S
R
IR
A
M
LAEA
P
V
V
N
DG
S
E
PV
PE
----
----
-
--G
RG
E
L
DV
N
IH
--
Q
FTYP
QT
D
H
PAL
E
N
V
N
F
A
L
K
P
G
QM
LGIC
G
P
TGSGKSTL
L
SLI
Q
R
H
F
D
V
S
EG
D
IR
F
HD
I
PL
TK
L
Q
L
D
S
W
R
SR
L
A
V
VSQ
T
P
F
LF
S
DTVANNIALG
-
CPNA
T
Q
Q
E
IE
H
V
AR
L
A
SVH
D
D
I
LR
L
PQ
G
Y
DT
E
V
GE
R
GV
M
LSGGQKQRI
S
IARALL
VNAE
ILILD
D
A
L
SA
V
D
GR
TE
H
Q
I
L
H
N
L
RQWG
Q
G
RT
V
I
IS
AHRLS
AL
T
E
A
S
EI
I
V
M
QH
G
H
I
AQ
RG
N
H
DE
L
A
QQS
G
W
Y
R
D
MY
R
Y
Q
QL
EAA
L
DD
V
PE
I
R
E
E
fig|585055.8.peg.471
Escherichia coli 55989 (1-586/590)
MR
L
F
A
QL
S
W
Y
FRR
E
------
W
--------
R
R
YLG
A
VALL
VI
--
-
--IA
ML
Q
L
VP
P
KVVGIVV
DG
VTEQHF
T
TGQ
I
L
M
W
I
A
TM
V
L
--
--
----
-
--
IA
VVV
Y
LLR
Y
VW
R
V
L
LFG
A
SYQ
LA
VE
LR
E
D
YYRQLS
RQ
H
P
E
F
YL
R
H
R
TG
D
L
M
A
R
A
TND
V
D
-------
R
VV
FAAGEGVL
T
L
V
-
-D
S
LV
M
G
CAV
L
I
M
M
ST
QI
SWQL
---
T
L
F
AL
L
P
M
PV
M
AI
MIKRNG
D
ALHE
RF
K
LAQ
A
AFS
S
L
ND
RTQE
S
LTS
I
--
-
-RM
I
KA
FG
-----------
LED
R
QSALFAADAEDTGKKN
M
R
VA
R
I
D
A
-
RF
DP
T
I
Y
I
AI
GM
A
N
--
LL
A
I
G
G
G
S
WMV
A
Q
GSLT
L
G
Q
LT
S
F
M
M
YLG
L
M
IW
P
M
LA
L
A
WM
FNIVERG
S
A
AY
S
R
IR
A
M
LAEA
P
V
V
N
DG
S
E
PV
PE
----
----
-
--G
RG
E
L
DV
N
IH
--
Q
FTYP
QT
D
H
PAL
E
N
V
N
F
A
L
K
P
G
QM
LGIC
G
P
TGSGKSTL
L
SLI
Q
R
H
F
D
V
S
EG
D
IR
F
HD
I
PL
TK
L
Q
L
D
S
W
R
SR
L
A
V
VSQ
T
P
F
LF
S
DTVANNIALG
-
CPNA
T
Q
Q
E
IE
H
V
AR
L
A
SVH
D
D
I
LR
L
PQ
G
Y
DT
E
V
GE
R
GV
M
LSGGQKQRI
S
IARALL
VNAE
ILILD
D
A
L
SA
V
D
GR
TE
H
Q
I
L
H
N
L
RQWG
Q
G
RT
V
I
IS
AHRLS
AL
T
E
A
S
EI
I
V
M
QH
G
H
I
AQ
RG
N
H
DE
L
A
QQS
G
W
Y
R
D
MY
R
Y
Q
QL
EAA
L
DD
V
PE
I
R
E
E
fig|409438.11.peg.600
Escherichia coli SE11 (1-586/590)
MR
L
F
A
QL
S
W
Y
FRR
E
------
W
--------
R
R
YLG
A
VALL
VI
--
-
--IA
ML
Q
L
VP
P
KVVGIVV
DG
VTEQHF
T
TGQ
I
L
M
W
I
A
TM
V
L
--
--
----
-
--
IA
VVV
Y
LLR
Y
VW
R
V
L
LFG
A
SYQ
LA
VE
LR
E
D
YYRQLS
RQ
H
P
E
F
YL
R
H
R
TG
D
L
M
A
R
A
TND
V
D
-------
R
VV
FAAGEGVL
T
L
V
-
-D
S
LV
M
G
CAV
L
I
M
M
ST
QI
SWQL
---
T
L
F
AL
L
P
M
PV
M
AI
MIKRNG
D
ALHE
RF
K
LAQ
A
AFS
S
L
ND
RTQE
S
LTS
I
--
-
-RM
I
KA
FG
-----------
LED
R
QSALFAADAEDTGKKN
M
R
VA
R
I
D
A
-
RF
DP
T
I
Y
I
AI
GM
A
N
--
LL
A
I
G
G
G
S
WMV
V
Q
GSLT
L
G
Q
LT
S
F
M
M
YLG
L
M
IW
P
M
LA
L
A
WM
FNIVERG
S
A
AY
S
R
IR
A
M
LAEA
P
V
V
N
DG
S
E
PV
PE
----
----
-
--G
RG
E
L
DV
N
IH
--
Q
FTYP
QT
D
H
PAL
E
N
V
N
F
A
L
K
P
G
QM
LGIC
G
P
TGSGKSTL
L
SLI
Q
R
H
F
D
V
S
EG
D
IR
F
HD
I
PL
TK
L
Q
L
D
S
W
R
SR
L
A
V
VSQ
T
P
F
LF
S
DTVANNIALG
-
CPNA
T
Q
Q
E
IE
H
V
AR
L
A
SVH
D
D
I
LR
L
PQ
G
Y
DT
E
V
GE
R
GV
M
LSGGQKQRI
S
IARALL
VNAE
ILILD
D
A
L
SA
V
D
GR
TE
H
Q
I
L
H
N
L
RQWG
Q
G
RT
V
I
IS
AHRLS
AL
T
E
A
S
EI
I
V
M
QH
G
H
I
AQ
RG
N
H
DE
L
A
QQS
G
W
Y
R
D
MY
R
Y
Q
QL
EAA
L
DDAPE
I
R
E
E
fig|656380.3.peg.1083
Escherichia coli FVEC1412 (1-586/590)
MR
L
F
A
QL
S
W
Y
FRR
E
------
W
--------
R
R
YLG
A
VALL
VI
--
-
--IA
ML
Q
L
VP
P
KVVGIVV
DG
VTEQHF
T
TGQ
I
L
M
W
I
A
TM
V
L
--
--
----
-
--
IA
VVV
Y
LLR
Y
VW
R
V
L
LFG
A
SYQ
LA
VE
LR
E
D
YYRQLS
RQ
H
P
E
F
YL
R
H
R
TG
D
L
M
A
R
A
TND
V
D
-------
R
VV
FAAGEGVL
T
L
V
-
-D
S
LV
M
G
CAV
L
I
M
M
ST
QI
SWQL
---
T
L
F
AL
L
P
M
PV
M
AI
MIKRNG
D
ALHE
RF
K
LAQ
A
AFS
S
L
ND
RTQE
S
LTS
I
--
-
-RM
I
KA
FG
-----------
LED
R
QSALFAADAEDTGKKN
M
R
VA
R
I
D
A
-
RF
DP
T
I
Y
I
AI
GM
A
N
--
LL
A
I
G
G
G
S
WMV
V
Q
GSLT
L
G
Q
LT
S
F
M
M
YLG
L
M
IW
P
M
LA
L
A
WM
FNIVERG
S
A
AY
S
R
IR
A
M
LAEA
P
V
V
N
DG
S
E
PV
PE
----
----
-
--G
RG
E
L
DV
N
IR
--
Q
FTYP
QT
D
H
PAL
E
N
V
N
F
A
L
K
P
G
QM
LGIC
G
P
TGSGKSTL
L
SLI
Q
R
H
F
D
V
S
EG
N
IR
F
HD
I
PL
TQ
L
Q
L
D
S
W
R
SR
L
A
V
VSQ
T
P
F
LF
S
DTVANNIALG
-
CPNA
T
Q
Q
E
IE
H
V
AR
L
A
SVH
D
D
I
LR
L
PQ
G
Y
DT
E
V
GE
R
GV
M
LSGGQKQRI
S
IARALL
VNAE
ILILD
D
A
L
SA
V
D
GR
TE
H
Q
I
L
H
N
L
RQWG
Q
G
RT
V
I
IS
AHRLS
AL
T
E
A
S
EI
I
V
M
QH
G
H
I
AQ
RG
N
H
DE
L
A
QQS
G
W
Y
R
D
MY
R
Y
Q
QL
EAA
L
DDAPE
I
R
E
E
fig|749549.3.peg.4322
Escherichia coli MS 198-1 (1-586/590)
MR
L
F
A
QL
S
W
Y
FRR
E
------
W
--------
R
R
YLG
A
VALL
VI
--
-
--IA
ML
Q
L
VP
P
KVVGIVV
DG
VTEQHF
T
TGQ
I
L
M
W
I
A
TM
V
L
--
--
----
-
--
IA
VVV
Y
LLR
Y
VW
R
V
L
LFG
A
SYQ
LA
VE
LR
E
D
YYRQLS
RQ
H
P
E
F
YL
R
H
R
TG
D
L
M
A
R
A
TND
V
D
-------
R
VV
FAAGEGVL
T
L
V
-
-D
S
LV
M
G
CAV
L
I
M
M
ST
QI
SWQL
---
T
L
F
AL
L
P
M
PV
M
AI
MIKRNG
D
ALHE
RF
K
LAQ
A
AFS
S
L
ND
RTQE
S
LTS
I
--
-
-RM
I
KA
FG
-----------
LED
R
QSALFAADAEDTGKKN
M
R
VA
R
I
D
A
-
RF
DP
T
I
Y
I
AI
GM
A
N
--
LL
A
I
G
G
G
S
WMV
V
Q
GSLT
L
G
Q
LT
S
F
M
M
YLG
L
M
IW
P
M
LA
L
A
WM
FNIVERG
S
A
AY
S
R
IR
A
M
LAEA
P
V
V
N
DG
S
E
PV
PE
----
----
-
--G
RG
E
L
DV
N
IR
--
Q
FTYP
QT
D
H
PAL
E
N
V
N
F
A
L
K
P
G
QM
LGIC
G
P
TGSGKSTL
L
SLI
Q
R
H
F
D
V
S
EG
N
IR
F
HD
I
PL
TQ
L
Q
L
D
S
W
R
SR
L
A
V
VSQ
T
P
F
LF
S
DTVANNIALG
-
CPNA
T
Q
Q
E
IE
H
V
AR
L
A
SVH
D
D
I
LR
L
PQ
G
Y
DT
E
V
GE
R
GV
M
LSGGQKQRI
S
IARALL
VNAE
ILILD
D
A
L
SA
V
D
GR
TE
H
Q
I
L
H
N
L
RQWG
Q
G
RT
V
I
IS
AHRLS
AL
T
E
A
S
EI
I
V
M
QH
G
H
I
AQ
RG
N
H
DE
L
A
QQS
G
W
Y
R
D
MY
R
Y
Q
QL
EAA
L
DDAPE
I
R
E
E
fig|585056.7.peg.693
Escherichia coli UMN026 (1-586/590)
MR
L
F
A
QL
S
W
Y
FRR
E
------
W
--------
R
R
YLG
A
VALL
VI
--
-
--IA
ML
Q
L
VP
P
KVVGIVV
DG
VTEQHF
T
TGQ
I
L
M
W
I
A
TM
V
L
--
--
----
-
--
IA
VVV
Y
LLR
Y
VW
R
V
L
LFG
A
SYQ
LA
VE
LR
E
D
YYRQLS
RQ
H
P
E
F
YL
R
H
R
TG
D
L
M
A
R
A
TND
V
D
-------
R
VV
FAAGEGVL
T
L
V
-
-D
S
LV
M
G
CAV
L
I
M
M
ST
QI
SWQL
---
T
L
F
AL
L
P
M
PV
M
AI
MIKRNG
D
ALHE
RF
K
LAQ
A
AFS
S
L
ND
RTQE
S
LTS
I
--
-
-RM
I
KA
FG
-----------
LED
R
QSALFAADAEDTGKKN
M
R
VA
R
I
D
A
-
RF
DP
T
I
Y
I
AI
GM
A
N
--
LL
A
I
G
G
G
S
WMV
V
Q
GSLT
L
G
Q
LT
S
F
M
M
YLG
L
M
IW
P
M
LA
L
A
WM
FNIVERG
S
A
AY
S
R
IR
A
M
LAEA
P
V
V
N
DG
S
E
PV
PE
----
----
-
--G
RG
E
L
DV
N
IR
--
Q
FTYP
QT
D
H
PAL
E
N
V
N
F
A
L
K
P
G
QM
LGIC
G
P
TGSGKSTL
L
SLI
Q
R
H
F
D
V
S
EG
N
IR
F
HD
I
PL
TQ
L
Q
L
D
S
W
R
SR
L
A
V
VSQ
T
P
F
LF
S
DTVANNIALG
-
CPNA
T
Q
Q
E
IE
H
V
AR
L
A
SVH
D
D
I
LR
L
PQ
G
Y
DT
E
V
GE
R
GV
M
LSGGQKQRI
S
IARALL
VNAE
ILILD
D
A
L
SA
V
D
GR
TE
H
Q
I
L
H
N
L
RQWG
Q
G
RT
V
I
IS
AHRLS
AL
T
E
A
S
EI
I
V
M
QH
G
H
I
AQ
RG
N
H
DE
L
A
QQS
G
W
Y
R
D
MY
R
Y
Q
QL
EAA
L
DDAPE
I
R
E
E
fig|656419.3.peg.655
Escherichia coli M718 (1-586/590)
MR
L
F
A
QL
S
W
Y
FRR
E
------
W
--------
R
R
YLG
A
VALL
VI
--
-
--IA
ML
Q
L
VP
P
KVVGIVV
DG
VTEQHF
T
TGQ
I
L
M
W
I
A
TM
V
L
--
--
----
-
--
IA
VVV
Y
LLR
Y
VW
R
V
L
LFG
A
SYQ
LA
VE
LR
E
D
YYRQLS
RQ
H
P
E
F
YL
R
H
R
TG
D
L
M
A
R
A
TND
V
D
-------
R
VV
FAAGEGVL
T
L
V
-
-D
S
LV
M
G
CAV
L
I
M
M
ST
QI
SWQL
---
T
L
F
AL
L
P
M
PV
M
AI
MIKRNG
D
ALHE
RF
K
LAQ
A
AFS
S
L
ND
RTQE
S
LTS
I
--
-
-RM
I
KA
FG
-----------
LED
R
QSALFAADAEDTGKKN
M
R
VA
R
I
D
A
-
RF
DP
T
I
Y
I
AI
GM
A
N
--
LL
A
I
G
G
G
S
WMV
V
Q
GSLT
L
G
Q
LT
S
F
M
M
YLG
L
M
IW
P
M
LA
L
A
WM
FNIVERG
S
A
AY
S
R
IR
A
M
LAEA
P
V
V
N
DG
S
E
PV
PE
----
----
-
--G
RG
E
L
DV
N
IH
--
Q
FTYP
QT
D
H
PAL
E
N
V
N
F
A
L
K
P
G
QM
LGIC
G
P
TGSGKSTL
L
SLI
Q
R
H
F
D
V
S
EG
D
IR
F
HD
I
PL
TK
L
Q
L
D
S
W
R
SR
L
A
V
VSQ
T
P
F
LF
S
DTVANNIALG
-
CPNA
T
Q
Q
E
IE
H
V
AR
L
A
SVH
D
D
I
LR
L
PQ
G
Y
DT
E
V
GE
R
GV
M
LSGGQKQRI
S
IARALL
VNAE
ILILD
D
A
L
SA
V
D
GR
TE
Y
Q
I
L
H
N
L
RQWG
Q
G
RT
V
I
IS
AHRLS
AL
T
E
A
S
EI
I
V
M
QH
G
H
I
AQ
RG
N
H
DE
L
A
QQS
G
W
Y
R
D
MY
R
Y
Q
QL
EAA
L
DDAPE
I
R
E
E
fig|550676.3.peg.1245
Escherichia coli B185 (1-586/590)
MR
L
F
A
QL
S
W
Y
FRR
E
------
W
--------
R
R
YLG
A
VALL
VI
--
-
--IA
ML
Q
L
VP
P
KVVGIVV
DG
VTEQHF
T
TGQ
I
L
M
W
I
A
TM
V
L
--
--
----
-
--
IA
VVV
Y
LLR
Y
VW
R
V
L
LFG
A
SYQ
LA
VE
LR
E
D
YYRQLS
RQ
H
P
E
F
YL
R
H
R
TG
D
L
M
A
R
A
TND
V
D
-------
R
VV
FAAGEGVL
T
L
V
-
-D
S
LV
M
G
CAV
L
I
M
M
ST
QI
SWQL
---
T
L
F
AL
L
P
M
PV
M
AI
MIKRNG
D
ALHE
RF
K
LAQ
A
AFS
S
L
ND
RTQE
S
LTS
I
--
-
-RM
I
KA
FG
-----------
LED
R
QSALFAADAEDTGKKN
M
R
VA
R
I
D
A
-
RF
DP
T
I
Y
I
AI
GM
A
N
--
LL
A
I
G
G
G
S
WMV
V
Q
GSLT
L
G
Q
LT
S
F
M
M
YLG
L
M
IW
P
M
LA
L
A
WM
FNIVERG
S
A
AY
S
R
IR
A
M
LAEA
P
V
V
N
DG
S
E
PV
PE
----
----
-
--G
RG
E
L
DV
N
IH
--
Q
FTYP
QT
D
Y
PAL
E
N
V
N
F
A
L
K
P
G
QM
LGIC
G
P
TGSGKSTL
L
SLI
Q
R
H
F
D
V
S
EG
D
IR
F
HD
I
PL
TK
L
Q
L
D
S
W
R
SR
L
A
V
VSQ
T
P
F
LF
S
DTVANNIALG
-
CPNA
T
Q
Q
E
IE
H
V
AR
L
A
SVH
D
D
I
LR
L
PQ
G
Y
DT
E
V
GE
R
GV
M
LSGGQKQRI
S
IARALL
VNAE
ILILD
D
A
L
SA
V
D
GR
TE
H
Q
I
L
H
N
L
RQWG
Q
G
RT
V
I
IS
AHRLS
AL
T
E
A
S
EI
I
V
M
QH
G
H
I
AQ
RG
N
H
DE
L
A
QQS
G
W
Y
R
D
MY
R
Y
Q
QL
EAA
L
DDAPE
I
R
E
E
fig|316401.4.peg.576
Escherichia coli ETEC H10407 (1-586/590)
MR
L
F
A
QL
S
W
Y
FRR
E
------
W
--------
R
R
YLG
A
VALL
VI
--
-
--IA
ML
Q
L
VP
P
KVVGIVV
DG
VTEQHF
T
TGQ
I
L
M
W
I
A
TM
V
L
--
--
----
-
--
IA
VVV
Y
LLR
Y
VW
R
V
L
LFG
A
SYQ
LA
VE
LR
E
D
YYRQLS
RQ
H
P
E
F
YL
R
H
R
TG
D
L
M
A
R
A
TND
V
D
-------
R
VV
FAAGEGVL
T
L
V
-
-D
S
LV
M
G
CAV
L
I
M
M
ST
QI
SWQL
---
T
L
F
AL
L
P
M
PV
M
AI
MIKRNG
D
ALHE
RF
K
LAQ
A
AFS
S
L
ND
RTQE
S
LTS
I
--
-
-RM
I
KA
FG
-----------
LED
R
QSALFAADAEDTGKKN
M
R
VA
R
I
D
A
-
RF
DP
T
I
Y
I
AI
GM
A
N
--
LL
A
I
G
G
G
S
WMV
V
Q
GSLT
L
G
Q
LT
S
F
M
M
YLG
L
M
IW
P
M
LA
L
A
WM
FNIVERG
S
A
AY
S
R
IR
A
M
LAEA
P
V
V
N
DG
S
E
PV
PE
----
----
-
--G
RG
E
L
DV
N
IR
--
Q
FTYP
QT
D
H
PAL
E
N
V
N
F
A
L
K
P
G
QM
LGIC
G
P
TGSGKSTL
L
SLI
Q
R
H
F
D
V
S
EG
D
IR
F
HD
I
PL
TK
L
Q
L
D
S
W
R
SR
L
A
V
VSQ
T
P
F
LF
S
DTVANNIALG
-
CPNA
T
Q
Q
E
IE
H
V
AR
L
A
SVH
D
D
I
LR
L
PQ
G
Y
DT
E
V
GE
R
GV
M
LSGGQKQRI
S
IARALL
VNAE
ILILD
D
A
L
SA
V
D
GR
TE
H
Q
I
L
H
N
L
RQWG
Q
G
RT
V
I
IS
AHRLS
AL
T
E
A
S
EI
I
V
M
QH
G
H
I
AQ
RG
N
H
DV
L
A
QQS
G
W
Y
R
D
MY
R
Y
Q
QL
EAA
L
DDAPE
I
R
E
E
fig|656444.3.peg.925
Escherichia coli TA280 (1-586/590)
MR
L
F
A
QL
S
W
Y
FRR
E
------
W
--------
R
R
YLG
A
VALL
VI
--
-
--IA
ML
Q
L
VP
P
KVVGIVV
DG
VTEQHF
T
TGQ
I
L
M
W
I
A
TM
V
L
--
--
----
-
--
IA
VVV
Y
LLR
Y
VW
R
V
L
LFG
A
SYQ
LA
VE
LR
E
D
YYRQLS
RQ
H
P
E
F
YL
R
H
R
TG
D
L
M
A
R
A
TND
V
D
-------
R
VV
FAAGEGVL
T
L
V
-
-D
S
LV
M
G
CAV
L
I
M
M
ST
QI
SWQL
---
T
L
F
AL
L
P
M
PV
M
AI
MIKRNG
D
ALHE
RF
K
LAQ
A
AFS
S
L
ND
RTQE
S
LTS
I
--
-
-RM
I
KA
FG
-----------
LED
R
QSALFAADAKDTGKKN
M
R
VA
R
I
D
A
-
RF
DP
T
I
Y
I
AI
GM
A
N
--
LL
A
I
G
G
G
S
WMV
V
Q
GSLT
L
G
Q
LT
S
F
M
M
YLG
L
M
IW
P
M
LA
L
A
WM
FNIVERG
S
A
AY
S
R
IR
A
M
LAEA
P
V
V
N
DG
S
E
PV
PE
----
----
-
--G
RG
E
L
DV
N
IH
--
Q
FTYP
QT
D
H
PAL
E
N
V
N
F
A
L
K
P
G
QM
LGIC
G
P
TGSGKSTL
L
SLI
Q
R
H
F
D
V
S
EG
D
IR
F
HD
I
PL
TK
L
Q
L
D
S
W
R
SR
L
A
V
VSQ
T
P
F
LF
S
DTVANNIALG
-
CPNA
T
Q
Q
E
IE
H
V
AR
L
A
SVH
D
D
I
LR
L
PQ
G
Y
DT
E
V
GE
R
GV
M
LSGGQKQRI
S
IARALL
VNAE
ILILD
D
A
L
SA
V
D
GR
TE
H
Q
I
L
H
N
L
RQWG
Q
G
RT
V
I
IS
AHRLS
AL
T
E
A
S
EI
I
V
M
QH
G
H
I
AQ
RG
N
H
DV
L
A
QQS
G
W
Y
R
D
MY
R
Y
Q
QL
EAA
L
DDAPE
I
R
E
E
fig|439855.10.peg.665
Escherichia coli SMS-3-5 (1-586/590)
MR
L
F
A
QL
S
W
Y
FRR
E
------
W
--------
R
R
YLG
A
VALL
VI
--
-
--IA
ML
Q
L
VP
P
KVVGIVV
DG
VTEQHF
T
TGQ
I
L
M
W
I
A
TM
V
L
--
--
----
-
--
IA
VVV
Y
LLR
Y
VW
R
V
L
LFG
A
SYQ
LA
VE
LR
E
D
YYRQLS
RQ
H
P
E
F
YL
R
H
R
TG
D
L
M
A
R
A
TND
V
D
-------
R
VV
FAAGEGVL
T
L
V
-
-D
S
LV
M
G
CAV
L
I
M
M
ST
QI
SWQL
---
T
L
F
AL
L
P
M
PV
M
AI
MIKRNG
D
ALHE
RF
K
LAQ
A
AFS
S
L
ND
RTQE
S
LTS
I
--
-
-RM
I
KA
FG
-----------
LED
R
QSALFAADAEDTGKKN
M
R
VA
R
I
D
A
-
RF
DP
T
I
Y
I
AI
GM
A
N
--
LL
A
I
G
G
G
S
WMV
V
Q
GSLT
L
G
Q
LT
S
F
M
M
YLG
L
M
IW
P
M
LA
L
A
WM
FNIVERG
S
A
AY
S
R
IR
T
M
LAEA
P
V
V
I
DG
S
D
KV
PE
----
----
-
--G
RG
E
L
DV
N
IR
--
Q
FTYP
QT
D
H
PAL
E
N
V
N
F
A
L
K
P
G
QM
V
GIC
G
P
TGSGKSTL
L
SLI
Q
R
H
F
D
V
S
EG
D
IR
F
HD
I
PL
TK
L
Q
L
D
S
W
R
SR
L
A
V
VSQ
T
P
F
LF
S
DTVANNIALG
-
CPNA
T
Q
Q
E
IE
H
V
AR
L
A
SVH
D
D
I
LR
L
PQ
G
Y
DT
E
V
GE
R
GV
M
LSGGQKQRI
S
IARALL
VNAE
ILILD
D
A
L
SA
V
D
GR
TE
H
Q
I
L
H
N
L
RQWG
Q
G
RT
V
I
IS
AHRLS
AL
T
E
A
S
EI
I
V
M
QH
G
H
I
AQ
RG
N
H
DV
L
A
QQS
G
W
Y
R
D
MY
R
Y
Q
QL
EAA
L
DDAPE
N
R
E
E
fig|679206.4.peg.100
Escherichia coli MS 119-7 (1-586/590)
MR
L
F
A
QL
S
W
Y
FRR
E
------
W
--------
R
R
YLG
A
VALL
VI
--
-
--IA
ML
Q
L
VP
P
KVVGIVV
DG
VTEQHF
T
TGQ
I
L
M
W
I
A
TM
V
L
--
--
----
-
--
IA
VVV
Y
LLR
Y
VW
R
V
L
LFG
A
SYQ
LA
VE
LR
E
D
YYRQLS
RQ
H
P
E
F
YL
R
H
R
TG
D
L
M
A
R
A
TND
V
D
-------
R
VV
FAAGEGVL
T
L
V
-
-D
S
LV
M
G
CAV
L
I
M
M
ST
QI
SWQL
---
T
L
F
AL
L
P
M
PV
M
AI
MIKRNG
D
ALHE
RF
K
LAQ
A
AFS
S
L
ND
RTQE
S
LTS
I
--
-
-RM
I
KA
FG
-----------
LED
R
QSALFAADAEDTGKKN
M
R
VA
R
I
D
A
-
RF
DP
T
I
Y
I
AI
GM
A
N
--
LL
A
I
G
G
G
S
WMV
V
Q
GSLT
L
G
Q
LT
S
F
M
M
YLG
L
M
IW
P
M
LA
L
A
WM
FNIVERG
S
A
AY
S
R
IR
A
M
LAEA
P
V
V
N
DG
S
E
PV
PE
----
----
-
--G
RG
E
L
DV
N
IH
--
Q
FTYP
QT
D
H
PAL
E
N
V
N
F
A
L
K
P
G
QM
LGIC
G
P
TGSGKSTL
L
SLI
Q
R
H
F
D
V
S
EG
D
IR
F
HD
I
PL
TK
L
Q
L
D
S
W
R
SR
L
A
V
VSQ
T
P
F
LF
S
DTVANNIALG
-
CPNA
T
Q
Q
E
IE
H
V
AR
L
A
SVH
D
D
I
LR
L
PQ
G
Y
DT
E
V
GE
R
GV
M
LSGGQKQRI
S
IARALL
VNAE
ILILD
D
A
L
SA
V
D
GR
TE
H
Q
I
L
H
N
L
RQWG
Q
G
RT
V
I
IS
AHRLS
AL
T
E
A
S
EI
I
V
M
QH
G
H
I
AQ
RG
N
H
DE
L
A
QQS
G
W
Y
R
D
MY
R
Y
Q
QL
EAA
L
DD
V
PE
I
R
E
E
fig|749533.3.peg.1350
Escherichia coli MS 84-1 (1-586/590)
MR
L
F
A
QL
S
W
Y
FRR
E
------
W
--------
R
R
YLG
A
VALL
VI
--
-
--IA
ML
Q
L
VP
P
KVVGIVV
DG
VTEQHF
T
TGQ
I
L
M
W
I
A
TM
V
L
--
--
----
-
--
IA
VVV
Y
LLR
Y
VW
R
V
L
LFG
A
SYQ
LA
VE
LR
E
D
YYRQLS
RQ
H
P
E
F
YL
R
H
R
TG
D
L
M
A
R
A
TND
V
D
-------
R
VV
FAAGEGVL
T
L
V
-
-D
S
LV
M
G
CAV
L
I
M
M
ST
QI
SWQL
---
T
L
F
AL
L
P
M
PV
M
AI
MIKRNG
D
ALHE
RF
K
LAQ
A
AFS
S
L
ND
RTQE
S
LTS
I
--
-
-RM
I
KA
FG
-----------
LED
R
QSALFAADAEDTGKKN
M
R
VA
R
I
D
A
-
RF
DP
T
I
Y
I
AI
GM
A
N
--
LL
A
I
G
G
G
S
WMV
V
Q
GSLT
L
G
Q
LT
S
F
M
M
YLG
L
M
IW
P
M
LA
L
A
WM
FNIVERG
S
A
AY
S
R
IR
A
M
LAEA
P
V
V
N
DG
S
E
PV
PE
----
----
-
--G
RG
E
L
DV
N
IH
--
Q
FTYP
QT
D
H
PAL
E
N
V
N
F
A
L
K
P
G
QM
LGIC
G
P
TGSGKSTL
L
SLI
Q
R
H
F
D
V
S
EG
D
IR
F
HD
I
PL
TK
L
Q
L
D
S
W
R
SR
L
A
V
VSQ
T
P
F
LF
S
DTVANNIALG
-
CPNA
T
Q
Q
E
IE
H
V
AR
L
A
SVH
D
D
I
LR
L
PQ
G
Y
DT
E
V
GE
R
GV
M
LSGGQKQRI
S
IARALL
VNAE
ILILD
D
A
L
SA
V
D
GR
TE
H
Q
I
L
H
N
L
RQWG
Q
G
RT
V
I
IS
AHRLS
AL
T
E
A
S
EI
I
V
M
QH
G
H
I
AQ
RG
N
H
DE
L
A
QQS
G
W
Y
R
D
MY
R
Y
Q
QL
EAA
L
DD
V
PE
I
R
E
E
fig|550677.3.peg.887
Escherichia coli B354 (1-586/590)
MR
L
F
A
QL
S
W
Y
FRR
E
------
W
--------
R
R
YLG
A
VALL
VI
--
-
--IA
ML
Q
L
VP
P
KVVGIVV
DG
VTEQHF
T
TGQ
I
L
M
W
I
A
TM
V
L
--
--
----
-
--
IA
VVV
Y
LLR
Y
VW
R
V
L
LFG
A
SYQ
LA
VE
LR
E
D
YYRQLS
RQ
H
P
E
F
YL
R
H
R
TG
D
L
M
A
R
A
TND
V
D
-------
R
VV
FAAGEGVL
T
L
V
-
-D
S
LV
M
G
CAV
L
I
M
M
ST
QI
SWQL
---
T
L
F
AL
L
P
M
PV
M
AI
MIKRNG
D
ALHE
RF
K
LAQ
A
AFS
S
L
ND
RTQE
S
LTS
I
--
-
-RM
I
KA
FG
-----------
LED
R
QSALFAADAEDTGKKN
M
R
VA
R
I
D
A
-
RF
DP
T
I
Y
I
AI
GM
A
N
--
LL
A
I
G
G
G
S
WMV
V
Q
GSLT
L
G
Q
LT
S
F
M
M
YLG
L
M
IW
P
M
LA
L
A
WM
FNIVERG
S
A
AY
S
R
IR
A
M
LAEA
P
V
V
N
DG
S
E
PV
PE
----
----
-
--G
RG
E
L
DV
N
IR
--
Q
FTYP
QT
D
H
PAL
E
N
V
N
F
A
L
K
P
G
QM
LGIC
G
P
TGSGKSTL
L
SLI
Q
R
H
F
D
V
S
K
G
D
IR
F
HD
I
PL
TK
L
Q
L
D
S
W
R
SR
L
A
V
VSQ
T
P
F
LF
S
DTVANNIALG
-
CPNA
T
Q
Q
E
IE
H
V
AR
L
A
SVH
D
D
I
LR
L
PQ
G
Y
G
T
E
V
GE
R
GV
M
LSGGQKQRI
S
IARALL
VNAE
ILILD
D
A
L
SA
V
D
GR
TE
H
Q
I
L
H
N
L
RQWG
Q
G
RT
V
I
IS
AHRLS
AL
T
E
A
S
EI
I
V
M
QH
G
H
I
AQ
RG
N
H
DV
L
V
QQS
G
W
Y
R
D
MY
R
Y
Q
QL
EAA
L
N
DAPE
I
R
E
E
fig|562.371.peg.2702
Escherichia coli 1044A (1-586/590)
MR
L
F
A
QL
S
W
Y
FRR
E
------
W
--------
R
R
YLG
A
VALL
VI
--
-
--IA
ML
Q
L
VP
P
KVVGIVV
DG
VTEQHF
T
TGQ
I
L
M
W
I
A
TM
V
L
--
--
----
-
--
IA
VVV
Y
LLR
Y
VW
R
V
L
LFG
A
SYQ
LA
VE
LR
E
D
YYRQLS
RQ
H
P
E
F
YL
R
H
R
TG
D
L
M
A
R
A
TND
V
D
-------
R
VV
FAAGEGVL
T
L
V
-
-D
S
LV
M
G
CAV
L
I
M
M
ST
QI
SWQL
---
T
L
F
AL
L
P
M
PV
M
AI
MIKRNG
D
ALHE
RF
K
LAQ
A
AFS
S
L
ND
RTQE
S
LTS
I
--
-
-RM
I
KA
FG
-----------
LED
R
QSALFAADAEDTGKKN
M
R
VA
R
I
D
A
-
RF
DP
T
I
Y
I
AI
GM
A
N
--
LL
A
I
G
G
G
S
WMV
V
Q
GSLT
L
G
Q
LT
S
F
M
M
YLG
L
M
IW
P
M
LA
L
A
WM
FNIVERG
S
A
AY
S
R
IR
A
M
LAEA
P
V
V
N
DG
S
E
PV
PE
----
----
-
--G
RG
E
L
DV
N
IH
--
Q
FTYP
QT
D
H
PAL
E
N
V
N
F
A
L
K
P
G
QM
LGIC
G
P
TGSGKSTL
L
SLI
Q
R
H
F
D
V
S
EG
D
IR
F
HD
I
PL
TK
L
Q
L
D
S
W
R
SR
L
A
V
VSQ
T
P
F
LF
S
DTVANNIALG
-
CPNA
T
Q
Q
E
IE
H
V
AR
L
A
SVH
D
D
I
LR
L
PQ
G
Y
DT
E
V
GE
R
GV
M
LSGGQKQRI
S
IARALL
VNAE
ILILD
D
A
L
SA
V
D
GR
TE
H
Q
I
L
H
N
L
RQWG
Q
G
RT
V
I
IS
AHRLS
AL
T
E
A
S
EI
I
V
M
QH
G
H
I
AQ
RG
N
H
DV
L
A
QQS
G
W
Y
R
D
MY
R
Y
Q
QL
EAA
L
DDAPE
N
R
E
E
fig|562.373.peg.3294
Escherichia coli 1125A (1-586/590)
MR
L
F
A
QL
S
W
Y
FRR
E
------
W
--------
R
R
YLG
A
VALL
VI
--
-
--IA
ML
Q
L
VP
P
KVVGIVV
DG
VTEQHF
T
TGQ
I
L
M
W
I
A
TM
V
L
--
--
----
-
--
IA
VVV
Y
LLR
Y
VW
R
V
L
LFG
A
SYQ
LA
VE
LR
E
D
YYRQLS
RQ
H
P
E
F
YL
R
H
R
TG
D
L
M
A
R
A
TND
V
D
-------
R
VV
FAAGEGVL
T
L
V
-
-D
S
LV
M
G
CAV
L
I
M
M
ST
QI
SWQL
---
T
L
F
AL
L
P
M
PV
M
AI
MIKRNG
D
ALHE
RF
K
LAQ
A
AFS
S
L
ND
RTQE
S
LTS
I
--
-
-RM
I
KA
FG
-----------
LED
R
QSALFAADAEDTGKKN
M
R
VA
R
I
D
A
-
RF
DP
T
I
Y
I
AI
GM
A
N
--
LL
A
I
G
G
G
S
WMV
V
Q
GSLT
L
G
Q
LT
S
F
M
M
YLG
L
M
IW
P
M
LA
L
A
WM
FNIVERG
S
A
AY
S
R
IR
A
M
LAEA
P
V
V
N
DG
S
E
PV
PE
----
----
-
--G
RG
E
L
DV
N
IH
--
Q
FTYP
QT
D
H
PAL
E
N
V
N
F
A
L
K
P
G
QM
LGIC
G
P
TGSGKSTL
L
SLI
Q
R
H
F
D
V
S
EG
D
IR
F
HD
I
PL
TK
L
Q
L
D
S
W
R
SR
L
A
V
VSQ
T
P
F
LF
S
DTVANNIALG
-
CPNA
T
Q
Q
E
IE
H
V
AR
L
A
SVH
D
D
I
LR
L
PQ
G
Y
DT
E
V
GE
R
GV
M
LSGGQKQRI
S
IARALL
VNAE
ILILD
D
A
L
SA
V
D
GR
TE
H
Q
I
L
H
N
L
RQWG
Q
G
RT
V
I
IS
AHRLS
AL
T
E
A
S
EI
I
V
M
QH
G
H
I
AQ
RG
N
H
DV
L
A
QQS
G
W
Y
R
D
MY
R
Y
Q
QL
EAA
L
DDAPE
N
R
E
E
fig|562.372.peg.1433
Escherichia coli 1212A (1-586/590)
MR
L
F
A
QL
S
W
Y
FRR
E
------
W
--------
R
R
YLG
A
VALL
VI
--
-
--IA
ML
Q
L
VP
P
KVVGIVV
DG
VTEQHF
T
TGQ
I
L
M
W
I
A
TM
V
L
--
--
----
-
--
IA
VVV
Y
LLR
Y
VW
R
V
L
LFG
A
SYQ
LA
VE
LR
E
D
YYRQLS
RQ
H
P
E
F
YL
R
H
R
TG
D
L
M
A
R
A
TND
V
D
-------
R
VV
FAAGEGVL
T
L
V
-
-D
S
LV
M
G
CAV
L
I
M
M
ST
QI
SWQL
---
T
L
F
AL
L
P
M
PV
M
AI
MIKRNG
D
ALHE
RF
K
LAQ
A
AFS
S
L
ND
RTQE
S
LTS
I
--
-
-RM
I
KA
FG
-----------
LED
R
QSALFAADAEDTGKKN
M
R
VA
R
I
D
A
-
RF
DP
T
I
Y
I
AI
GM
A
N
--
LL
A
I
G
G
G
S
WMV
V
Q
GSLT
L
G
Q
LT
S
F
M
M
YLG
L
M
IW
P
M
LA
L
A
WM
FNIVERG
S
A
AY
S
R
IR
A
M
LAEA
P
V
V
N
DG
S
E
PV
PE
----
----
-
--G
RG
E
L
DV
N
IH
--
Q
FTYP
QT
D
H
PAL
E
N
V
N
F
A
L
K
P
G
QM
LGIC
G
P
TGSGKSTL
L
SLI
Q
R
H
F
D
V
S
EG
D
IR
F
HD
I
PL
TK
L
Q
L
D
S
W
R
SR
L
A
V
VSQ
T
P
F
LF
S
DTVANNIALG
-
CPNA
T
Q
Q
E
IE
H
V
AR
L
A
SVH
D
D
I
LR
L
PQ
G
Y
DT
E
V
GE
R
GV
M
LSGGQKQRI
S
IARALL
VNAE
ILILD
D
A
L
SA
V
D
GR
TE
H
Q
I
L
H
N
L
RQWG
Q
G
RT
V
I
IS
AHRLS
AL
T
E
A
S
EI
I
V
M
QH
G
H
I
AQ
RG
N
H
DV
L
A
QQS
G
W
Y
R
D
MY
R
Y
Q
QL
EAA
L
DDAPE
N
R
E
E
fig|344610.3.peg.1457
Escherichia coli 53638 (1-586/590)
MR
L
F
A
QL
S
W
Y
FRR
E
------
W
--------
R
R
YLG
A
VALL
VI
--
-
--IA
ML
Q
L
VP
P
KVVGIVV
DG
VTEQHF
T
TGQ
I
L
M
W
I
A
TM
V
L
--
--
----
-
--
IA
VVV
Y
LLR
Y
VW
R
V
L
LFG
A
SYQ
LA
VE
LR
E
D
YYRQLS
RQ
H
P
E
F
YL
R
H
R
TG
D
L
M
A
R
A
TND
V
D
-------
R
VV
FAAGEGVL
T
L
V
-
-D
S
LV
M
G
CAV
L
I
M
M
ST
QI
SWQL
---
T
L
F
AL
L
P
M
PV
M
AI
MIKRNG
D
ALHE
RF
K
LAQ
A
AFS
S
L
ND
RTQE
S
LTS
I
--
-
-RM
I
KA
FG
-----------
LED
R
QSALFAADAEDTGKKN
M
R
VA
R
I
D
A
-
RF
DP
T
I
Y
I
AI
GM
A
N
--
LL
A
I
G
G
G
S
WMV
V
Q
GSLT
L
G
Q
LT
S
F
M
M
YLG
L
M
IW
P
M
LA
L
A
WM
FNIVERG
S
A
AY
S
R
IR
A
M
LAEA
P
V
V
N
DG
S
E
PV
PE
----
----
-
--G
RG
E
L
DV
N
IH
--
Q
FTYP
QT
D
H
PAL
E
N
V
N
F
A
L
K
P
G
QM
LGIC
G
P
TGSGKSTL
L
SLI
Q
R
H
F
D
V
S
EG
D
IR
F
HD
I
PL
TK
L
Q
L
D
S
W
R
SR
L
A
V
VSQ
T
P
F
LF
S
DTVANNIALG
-
CPNA
T
Q
Q
E
IE
H
V
AR
L
A
SVH
D
D
I
LR
L
PQ
G
Y
DT
E
V
GE
R
GV
M
LSGGQKQRI
S
IARALL
VNAE
ILILD
D
A
L
SA
V
D
GR
TE
H
Q
I
L
H
N
L
RQWG
Q
G
RT
V
I
IS
AHRLS
AL
T
E
A
S
EI
I
V
M
QH
G
H
I
AQ
RG
N
H
DV
L
A
QQS
G
W
Y
R
D
MY
R
Y
Q
QL
EAA
L
DDAPE
N
R
E
E
fig|344610.7.peg.1225
Escherichia coli 53638 (1-586/590)
MR
L
F
A
QL
S
W
Y
FRR
E
------
W
--------
R
R
YLG
A
VALL
VI
--
-
--IA
ML
Q
L
VP
P
KVVGIVV
DG
VTEQHF
T
TGQ
I
L
M
W
I
A
TM
V
L
--
--
----
-
--
IA
VVV
Y
LLR
Y
VW
R
V
L
LFG
A
SYQ
LA
VE
LR
E
D
YYRQLS
RQ
H
P
E
F
YL
R
H
R
TG
D
L
M
A
R
A
TND
V
D
-------
R
VV
FAAGEGVL
T
L
V
-
-D
S
LV
M
G
CAV
L
I
M
M
ST
QI
SWQL
---
T
L
F
AL
L
P
M
PV
M
AI
MIKRNG
D
ALHE
RF
K
LAQ
A
AFS
S
L
ND
RTQE
S
LTS
I
--
-
-RM
I
KA
FG
-----------
LED
R
QSALFAADAEDTGKKN
M
R
VA
R
I
D
A
-
RF
DP
T
I
Y
I
AI
GM
A
N
--
LL
A
I
G
G
G
S
WMV
V
Q
GSLT
L
G
Q
LT
S
F
M
M
YLG
L
M
IW
P
M
LA
L
A
WM
FNIVERG
S
A
AY
S
R
IR
A
M
LAEA
P
V
V
N
DG
S
E
PV
PE
----
----
-
--G
RG
E
L
DV
N
IH
--
Q
FTYP
QT
D
H
PAL
E
N
V
N
F
A
L
K
P
G
QM
LGIC
G
P
TGSGKSTL
L
SLI
Q
R
H
F
D
V
S
EG
D
IR
F
HD
I
PL
TK
L
Q
L
D
S
W
R
SR
L
A
V
VSQ
T
P
F
LF
S
DTVANNIALG
-
CPNA
T
Q
Q
E
IE
H
V
AR
L
A
SVH
D
D
I
LR
L
PQ
G
Y
DT
E
V
GE
R
GV
M
LSGGQKQRI
S
IARALL
VNAE
ILILD
D
A
L
SA
V
D
GR
TE
H
Q
I
L
H
N
L
RQWG
Q
G
RT
V
I
IS
AHRLS
AL
T
E
A
S
EI
I
V
M
QH
G
H
I
AQ
RG
N
H
DV
L
A
QQS
G
W
Y
R
D
MY
R
Y
Q
QL
EAA
L
DDAPE
N
R
E
E
fig|562.374.peg.5543
Escherichia coli 536A (1-586/590)
MR
L
F
A
QL
S
W
Y
FRR
E
------
W
--------
R
R
YLG
A
VALL
VI
--
-
--IA
ML
Q
L
VP
P
KVVGIVV
DG
VTEQHF
T
TGQ
I
L
M
W
I
A
TM
V
L
--
--
----
-
--
IA
VVV
Y
LLR
Y
VW
R
V
L
LFG
A
SYQ
LA
VE
LR
E
D
YYRQLS
RQ
H
P
E
F
YL
R
H
R
TG
D
L
M
A
R
A
TND
V
D
-------
R
VV
FAAGEGVL
T
L
V
-
-D
S
LV
M
G
CAV
L
I
M
M
ST
QI
SWQL
---
T
L
F
AL
L
P
M
PV
M
AI
MIKRNG
D
ALHE
RF
K
LAQ
A
AFS
S
L
ND
RTQE
S
LTS
I
--
-
-RM
I
KA
FG
-----------
LED
R
QSALFAADAEDTGKKN
M
R
VA
R
I
D
A
-
RF
DP
T
I
Y
I
AI
GM
A
N
--
LL
A
I
G
G
G
S
WMV
V
Q
GSLT
L
G
Q
LT
S
F
M
M
YLG
L
M
IW
P
M
LA
L
A
WM
FNIVERG
S
A
AY
S
R
IR
A
M
LAEA
P
V
V
N
DG
S
E
PV
PE
----
----
-
--G
RG
E
L
DV
N
IH
--
Q
FTYP
QT
D
H
PAL
E
N
V
N
F
A
L
K
P
G
QM
LGIC
G
P
TGSGKSTL
L
SLI
Q
R
H
F
D
V
S
EG
D
IR
F
HD
I
PL
TK
L
Q
L
D
S
W
R
SR
L
A
V
VSQ
T
P
F
LF
S
DTVANNIALG
-
CPNA
T
Q
Q
E
IE
H
V
AR
L
A
SVH
D
D
I
LR
L
PQ
G
Y
DT
E
V
GE
R
GV
M
LSGGQKQRI
S
IARALL
VNAE
ILILD
D
A
L
SA
V
D
GR
TE
H
Q
I
L
H
N
L
RQWG
Q
G
RT
V
I
IS
AHRLS
AL
T
E
A
S
EI
I
V
M
QH
G
H
I
AQ
RG
N
H
DV
L
A
QQS
G
W
Y
R
D
MY
R
Y
Q
QL
EAA
L
DDAPE
N
R
E
E
fig|481805.3.peg.3391
Escherichia coli ATCC 8739 (1-586/590)
MR
L
F
A
QL
S
W
Y
FRR
E
------
W
--------
R
R
YLG
A
VALL
VI
--
-
--IA
ML
Q
L
VP
P
KVVGIVV
DG
VTEQHF
T
TGQ
I
L
M
W
I
A
TM
V
L
--
--
----
-
--
IA
VVV
Y
LLR
Y
VW
R
V
L
LFG
A
SYQ
LA
VE
LR
E
D
YYRQLS
RQ
H
P
E
F
YL
R
H
R
TG
D
L
M
A
R
A
TND
V
D
-------
R
VV
FAAGEGVL
T
L
V
-
-D
S
LV
M
G
CAV
L
I
M
M
ST
QI
SWQL
---
T
L
F
AL
L
P
M
PV
M
AI
MIKRNG
D
ALHE
RF
K
LAQ
A
AFS
S
L
ND
RTQE
S
LTS
I
--
-
-RM
I
KA
FG
-----------
LED
R
QSALFAADAEDTGKKN
M
R
VA
R
I
D
A
-
RF
DP
T
I
Y
I
AI
GM
A
N
--
LL
A
I
G
G
G
S
WMV
V
Q
GSLT
L
G
Q
LT
S
F
M
M
YLG
L
M
IW
P
M
LA
L
A
WM
FNIVERG
S
A
AY
S
R
IR
A
M
LAEA
P
V
V
N
DG
S
E
PV
PE
----
----
-
--G
RG
E
L
DV
N
IH
--
Q
FTYP
QT
D
H
PAL
E
N
V
N
F
A
L
K
P
G
QM
LGIC
G
P
TGSGKSTL
L
SLI
Q
R
H
F
D
V
S
EG
D
IR
F
HD
I
PL
TK
L
Q
L
D
S
W
R
SR
L
A
V
VSQ
T
P
F
LF
S
DTVANNIALG
-
CPNA
T
Q
Q
E
IE
H
V
AR
L
A
SVH
D
D
I
LR
L
PQ
G
Y
DT
E
V
GE
R
GV
M
LSGGQKQRI
S
IARALL
VNAE
ILILD
D
A
L
SA
V
D
GR
TE
H
Q
I
L
H
N
L
RQWG
Q
G
RT
V
I
IS
AHRLS
AL
T
E
A
S
EI
I
V
M
QH
G
H
I
AQ
RG
N
H
DV
L
A
QQS
G
W
Y
R
D
MY
R
Y
Q
QL
EAA
L
DDAPE
N
R
E
E
fig|481805.6.peg.3380
Escherichia coli ATCC 8739 (1-586/590)
MR
L
F
A
QL
S
W
Y
FRR
E
------
W
--------
R
R
YLG
A
VALL
VI
--
-
--IA
ML
Q
L
VP
P
KVVGIVV
DG
VTEQHF
T
TGQ
I
L
M
W
I
A
TM
V
L
--
--
----
-
--
IA
VVV
Y
LLR
Y
VW
R
V
L
LFG
A
SYQ
LA
VE
LR
E
D
YYRQLS
RQ
H
P
E
F
YL
R
H
R
TG
D
L
M
A
R
A
TND
V
D
-------
R
VV
FAAGEGVL
T
L
V
-
-D
S
LV
M
G
CAV
L
I
M
M
ST
QI
SWQL
---
T
L
F
AL
L
P
M
PV
M
AI
MIKRNG
D
ALHE
RF
K
LAQ
A
AFS
S
L
ND
RTQE
S
LTS
I
--
-
-RM
I
KA
FG
-----------
LED
R
QSALFAADAEDTGKKN
M
R
VA
R
I
D
A
-
RF
DP
T
I
Y
I
AI
GM
A
N
--
LL
A
I
G
G
G
S
WMV
V
Q
GSLT
L
G
Q
LT
S
F
M
M
YLG
L
M
IW
P
M
LA
L
A
WM
FNIVERG
S
A
AY
S
R
IR
A
M
LAEA
P
V
V
N
DG
S
E
PV
PE
----
----
-
--G
RG
E
L
DV
N
IH
--
Q
FTYP
QT
D
H
PAL
E
N
V
N
F
A
L
K
P
G
QM
LGIC
G
P
TGSGKSTL
L
SLI
Q
R
H
F
D
V
S
EG
D
IR
F
HD
I
PL
TK
L
Q
L
D
S
W
R
SR
L
A
V
VSQ
T
P
F
LF
S
DTVANNIALG
-
CPNA
T
Q
Q
E
IE
H
V
AR
L
A
SVH
D
D
I
LR
L
PQ
G
Y
DT
E
V
GE
R
GV
M
LSGGQKQRI
S
IARALL
VNAE
ILILD
D
A
L
SA
V
D
GR
TE
H
Q
I
L
H
N
L
RQWG
Q
G
RT
V
I
IS
AHRLS
AL
T
E
A
S
EI
I
V
M
QH
G
H
I
AQ
RG
N
H
DV
L
A
QQS
G
W
Y
R
D
MY
R
Y
Q
QL
EAA
L
DDAPE
N
R
E
E
fig|331112.3.peg.489
Escherichia coli HS (1-586/590)
MR
L
F
A
QL
S
W
Y
FRR
E
------
W
--------
R
R
YLG
A
VALL
VI
--
-
--IA
ML
Q
L
VP
P
KVVGIVV
DG
VTEQHF
T
TGQ
I
L
M
W
I
A
TM
V
L
--
--
----
-
--
IA
VVV
Y
LLR
Y
VW
R
V
L
LFG
A
SYQ
LA
VE
LR
E
D
YYRQLS
RQ
H
P
E
F
YL
R
H
R
TG
D
L
M
A
R
A
TND
V
D
-------
R
VV
FAAGEGVL
T
L
V
-
-D
S
LV
M
G
CAV
L
I
M
M
ST
QI
SWQL
---
T
L
F
AL
L
P
M
PV
M
AI
MIKRNG
D
ALHE
RF
K
LAQ
A
AFS
S
L
ND
RTQE
S
LTS
I
--
-
-RM
I
KA
FG
-----------
LED
R
QSALFAADAEDTGKKN
M
R
VA
R
I
D
A
-
RF
DP
T
I
Y
I
AI
GM
A
N
--
LL
A
I
G
G
G
S
WMV
V
Q
GSLT
L
G
Q
LT
S
F
M
M
YLG
L
M
IW
P
M
LA
L
A
WM
FNIVERG
S
A
AY
S
R
IR
A
M
LAEA
P
V
V
N
DG
S
E
PV
PE
----
----
-
--G
RG
E
L
DV
N
IH
--
Q
FTYP
QT
D
H
PAL
E
N
V
N
F
A
L
K
P
G
QM
LGIC
G
P
TGSGKSTL
L
SLI
Q
R
H
F
D
V
S
EG
D
IR
F
HD
I
PL
TK
L
Q
L
D
S
W
R
SR
L
A
V
VSQ
T
P
F
LF
S
DTVANNIALG
-
CPNA
T
Q
Q
E
IE
H
V
AR
L
A
SVH
D
D
I
LR
L
PQ
G
Y
DT
E
V
GE
R
GV
M
LSGGQKQRI
S
IARALL
VNAE
ILILD
D
A
L
SA
V
D
GR
TE
H
Q
I
L
H
N
L
RQWG
Q
G
RT
V
I
IS
AHRLS
AL
T
E
A
S
EI
I
V
M
QH
G
H
I
AQ
RG
N
H
DV
L
A
QQS
G
W
Y
R
D
MY
R
Y
Q
QL
EAA
L
DDAPE
N
R
E
E
fig|331112.6.peg.513
Escherichia coli HS (1-586/590)
MR
L
F
A
QL
S
W
Y
FRR
E
------
W
--------
R
R
YLG
A
VALL
VI
--
-
--IA
ML
Q
L
VP
P
KVVGIVV
DG
VTEQHF
T
TGQ
I
L
M
W
I
A
TM
V
L
--
--
----
-
--
IA
VVV
Y
LLR
Y
VW
R
V
L
LFG
A
SYQ
LA
VE
LR
E
D
YYRQLS
RQ
H
P
E
F
YL
R
H
R
TG
D
L
M
A
R
A
TND
V
D
-------
R
VV
FAAGEGVL
T
L
V
-
-D
S
LV
M
G
CAV
L
I
M
M
ST
QI
SWQL
---
T
L
F
AL
L
P
M
PV
M
AI
MIKRNG
D
ALHE
RF
K
LAQ
A
AFS
S
L
ND
RTQE
S
LTS
I
--
-
-RM
I
KA
FG
-----------
LED
R
QSALFAADAEDTGKKN
M
R
VA
R
I
D
A
-
RF
DP
T
I
Y
I
AI
GM
A
N
--
LL
A
I
G
G
G
S
WMV
V
Q
GSLT
L
G
Q
LT
S
F
M
M
YLG
L
M
IW
P
M
LA
L
A
WM
FNIVERG
S
A
AY
S
R
IR
A
M
LAEA
P
V
V
N
DG
S
E
PV
PE
----
----
-
--G
RG
E
L
DV
N
IH
--
Q
FTYP
QT
D
H
PAL
E
N
V
N
F
A
L
K
P
G
QM
LGIC
G
P
TGSGKSTL
L
SLI
Q
R
H
F
D
V
S
EG
D
IR
F
HD
I
PL
TK
L
Q
L
D
S
W
R
SR
L
A
V
VSQ
T
P
F
LF
S
DTVANNIALG
-
CPNA
T
Q
Q
E
IE
H
V
AR
L
A
SVH
D
D
I
LR
L
PQ
G
Y
DT
E
V
GE
R
GV
M
LSGGQKQRI
S
IARALL
VNAE
ILILD
D
A
L
SA
V
D
GR
TE
H
Q
I
L
H
N
L
RQWG
Q
G
RT
V
I
IS
AHRLS
AL
T
E
A
S
EI
I
V
M
QH
G
H
I
AQ
RG
N
H
DV
L
A
QQS
G
W
Y
R
D
MY
R
Y
Q
QL
EAA
L
DDAPE
N
R
E
E
fig|749537.3.peg.1859
Escherichia coli MS 115-1 (1-586/590)
MR
L
F
A
QL
S
W
Y
FRR
E
------
W
--------
R
R
YLG
A
VALL
VI
--
-
--IA
ML
Q
L
VP
P
KVVGIVV
DG
VTEQHF
T
TGQ
I
L
M
W
I
A
TM
V
L
--
--
----
-
--
IA
VVV
Y
LLR
Y
VW
R
V
L
LFG
A
SYQ
LA
VE
LR
E
D
YYRQLS
RQ
H
P
E
F
YL
R
H
R
TG
D
L
M
A
R
A
TND
V
D
-------
R
VV
FAAGEGVL
T
L
V
-
-D
S
LV
M
G
CAV
L
I
M
M
ST
QI
SWQL
---
T
L
F
AL
L
P
M
PV
M
AI
MIKRNG
D
ALHE
RF
K
LAQ
A
AFS
S
L
ND
RTQE
S
LTS
I
--
-
-RM
I
KA
FG
-----------
LED
R
QSALFAADAEDTGKKN
M
R
VA
R
I
D
A
-
RF
DP
T
I
Y
I
AI
GM
A
N
--
LL
A
I
G
G
G
S
WMV
V
Q
GSLT
L
G
Q
LT
S
F
M
M
YLG
L
M
IW
P
M
LA
L
A
WM
FNIVERG
S
A
AY
S
R
IR
A
M
LAEA
P
V
V
N
DG
S
E
PV
PE
----
----
-
--G
RG
E
L
DV
N
IH
--
Q
FTYP
QT
D
H
PAL
E
N
V
N
F
A
L
K
P
G
QM
LGIC
G
P
TGSGKSTL
L
SLI
Q
R
H
F
D
V
S
EG
D
IR
F
HD
I
PL
TK
L
Q
L
D
S
W
R
SR
L
A
V
VSQ
T
P
F
LF
S
DTVANNIALG
-
CPNA
T
Q
Q
E
IE
H
V
AR
L
A
SVH
D
D
I
LR
L
PQ
G
Y
DT
E
V
GE
R
GV
M
LSGGQKQRI
S
IARALL
VNAE
ILILD
D
A
L
SA
V
D
GR
TE
H
Q
I
L
H
N
L
RQWG
Q
G
RT
V
I
IS
AHRLS
AL
T
E
A
S
EI
I
V
M
QH
G
H
I
AQ
RG
N
H
DV
L
A
QQS
G
W
Y
R
D
MY
R
Y
Q
QL
EAA
L
DDAPE
N
R
E
E
fig|83334.1.peg.579
Escherichia coli O157:H7 (1-586/590)
MR
L
F
A
QL
S
W
Y
FRR
E
------
W
--------
R
R
YLG
A
VALL
VI
--
-
--IA
ML
Q
L
VP
P
KVVGIVV
DG
VTEQHF
T
TGQ
I
L
M
W
I
A
TM
V
L
--
--
----
-
--
IA
VVV
Y
LLR
Y
VW
R
V
L
LFG
A
SYQ
LA
VE
LR
E
D
YYRQLS
RQ
H
P
E
F
YL
R
H
R
TG
D
L
M
A
R
A
TND
V
D
-------
R
VV
FAAGEGVL
T
L
V
-
-D
S
LV
M
G
CAV
L
I
M
M
ST
QI
SWQL
---
T
L
F
AL
L
P
M
PV
M
AI
MIKRNG
D
ALHE
RF
K
LAQ
A
AFS
S
L
ND
RTQE
S
LTS
I
--
-
-RM
I
KA
FG
-----------
LED
R
QSALFAADAEDTGKKN
M
R
VA
R
I
D
A
-
RF
DP
T
I
Y
I
AI
GM
A
N
--
LL
A
I
G
G
G
S
WMV
V
Q
GSLT
L
G
Q
LT
S
F
M
M
YLG
L
M
IW
P
M
LA
L
A
WM
FNIVERG
S
A
AY
S
R
IR
A
M
LAEA
P
V
V
N
DG
S
E
PV
PE
----
----
-
--G
RG
E
L
DV
N
IH
--
Q
FTYP
QT
D
H
PAL
E
N
V
N
F
A
L
K
P
G
QM
LGIC
G
P
TGSGKSTL
L
SLI
Q
R
H
F
D
V
S
EG
D
IR
F
HD
I
PL
TK
L
Q
L
D
S
W
R
SR
L
A
V
VSQ
T
P
F
LF
S
DTVANNIALG
-
CPNA
T
Q
Q
E
IE
H
V
AR
L
A
SVH
D
D
I
LR
L
PQ
G
Y
DT
E
V
GE
R
GV
M
LSGGQKQRI
S
IARALL
VNAE
ILILD
D
A
L
SA
V
D
GR
TE
H
Q
I
L
H
N
L
RQWG
Q
G
RT
V
I
IS
AHRLS
AL
T
E
A
S
EI
I
V
M
QH
G
H
I
AQ
RG
N
H
DV
L
A
QQS
G
W
Y
R
D
MY
R
Y
Q
QL
EAA
L
DDAPE
N
R
E
E
fig|155864.1.peg.498
Escherichia coli O157:H7 EDL933 (1-586/590)
MR
L
F
A
QL
S
W
Y
FRR
E
------
W
--------
R
R
YLG
A
VALL
VI
--
-
--IA
ML
Q
L
VP
P
KVVGIVV
DG
VTEQHF
T
TGQ
I
L
M
W
I
A
TM
V
L
--
--
----
-
--
IA
VVV
Y
LLR
Y
VW
R
V
L
LFG
A
SYQ
LA
VE
LR
E
D
YYRQLS
RQ
H
P
E
F
YL
R
H
R
TG
D
L
M
A
R
A
TND
V
D
-------
R
VV
FAAGEGVL
T
L
V
-
-D
S
LV
M
G
CAV
L
I
M
M
ST
QI
SWQL
---
T
L
F
AL
L
P
M
PV
M
AI
MIKRNG
D
ALHE
RF
K
LAQ
A
AFS
S
L
ND
RTQE
S
LTS
I
--
-
-RM
I
KA
FG
-----------
LED
R
QSALFAADAEDTGKKN
M
R
VA
R
I
D
A
-
RF
DP
T
I
Y
I
AI
GM
A
N
--
LL
A
I
G
G
G
S
WMV
V
Q
GSLT
L
G
Q
LT
S
F
M
M
YLG
L
M
IW
P
M
LA
L
A
WM
FNIVERG
S
A
AY
S
R
IR
A
M
LAEA
P
V
V
N
DG
S
E
PV
PE
----
----
-
--G
RG
E
L
DV
N
IH
--
Q
FTYP
QT
D
H
PAL
E
N
V
N
F
A
L
K
P
G
QM
LGIC
G
P
TGSGKSTL
L
SLI
Q
R
H
F
D
V
S
EG
D
IR
F
HD
I
PL
TK
L
Q
L
D
S
W
R
SR
L
A
V
VSQ
T
P
F
LF
S
DTVANNIALG
-
CPNA
T
Q
Q
E
IE
H
V
AR
L
A
SVH
D
D
I
LR
L
PQ
G
Y
DT
E
V
GE
R
GV
M
LSGGQKQRI
S
IARALL
VNAE
ILILD
D
A
L
SA
V
D
GR
TE
H
Q
I
L
H
N
L
RQWG
Q
G
RT
V
I
IS
AHRLS
AL
T
E
A
S
EI
I
V
M
QH
G
H
I
AQ
RG
N
H
DV
L
A
QQS
G
W
Y
R
D
MY
R
Y
Q
QL
EAA
L
DDAPE
N
R
E
E
fig|155864.8.peg.506
Escherichia coli O157:H7 EDL933 (1-586/590)
MR
L
F
A
QL
S
W
Y
FRR
E
------
W
--------
R
R
YLG
A
VALL
VI
--
-
--IA
ML
Q
L
VP
P
KVVGIVV
DG
VTEQHF
T
TGQ
I
L
M
W
I
A
TM
V
L
--
--
----
-
--
IA
VVV
Y
LLR
Y
VW
R
V
L
LFG
A
SYQ
LA
VE
LR
E
D
YYRQLS
RQ
H
P
E
F
YL
R
H
R
TG
D
L
M
A
R
A
TND
V
D
-------
R
VV
FAAGEGVL
T
L
V
-
-D
S
LV
M
G
CAV
L
I
M
M
ST
QI
SWQL
---
T
L
F
AL
L
P
M
PV
M
AI
MIKRNG
D
ALHE
RF
K
LAQ
A
AFS
S
L
ND
RTQE
S
LTS
I
--
-
-RM
I
KA
FG
-----------
LED
R
QSALFAADAEDTGKKN
M
R
VA
R
I
D
A
-
RF
DP
T
I
Y
I
AI
GM
A
N
--
LL
A
I
G
G
G
S
WMV
V
Q
GSLT
L
G
Q
LT
S
F
M
M
YLG
L
M
IW
P
M
LA
L
A
WM
FNIVERG
S
A
AY
S
R
IR
A
M
LAEA
P
V
V
N
DG
S
E
PV
PE
----
----
-
--G
RG
E
L
DV
N
IH
--
Q
FTYP
QT
D
H
PAL
E
N
V
N
F
A
L
K
P
G
QM
LGIC
G
P
TGSGKSTL
L
SLI
Q
R
H
F
D
V
S
EG
D
IR
F
HD
I
PL
TK
L
Q
L
D
S
W
R
SR
L
A
V
VSQ
T
P
F
LF
S
DTVANNIALG
-
CPNA
T
Q
Q
E
IE
H
V
AR
L
A
SVH
D
D
I
LR
L
PQ
G
Y
DT
E
V
GE
R
GV
M
LSGGQKQRI
S
IARALL
VNAE
ILILD
D
A
L
SA
V
D
GR
TE
H
Q
I
L
H
N
L
RQWG
Q
G
RT
V
I
IS
AHRLS
AL
T
E
A
S
EI
I
V
M
QH
G
H
I
AQ
RG
N
H
DV
L
A
QQS
G
W
Y
R
D
MY
R
Y
Q
QL
EAA
L
DDAPE
N
R
E
E
fig|444454.5.peg.4979
Escherichia coli O157:H7 str. EC4024 (1-586/590)
MR
L
F
A
QL
S
W
Y
FRR
E
------
W
--------
R
R
YLG
A
VALL
VI
--
-
--IA
ML
Q
L
VP
P
KVVGIVV
DG
VTEQHF
T
TGQ
I
L
M
W
I
A
TM
V
L
--
--
----
-
--
IA
VVV
Y
LLR
Y
VW
R
V
L
LFG
A
SYQ
LA
VE
LR
E
D
YYRQLS
RQ
H
P
E
F
YL
R
H
R
TG
D
L
M
A
R
A
TND
V
D
-------
R
VV
FAAGEGVL
T
L
V
-
-D
S
LV
M
G
CAV
L
I
M
M
ST
QI
SWQL
---
T
L
F
AL
L
P
M
PV
M
AI
MIKRNG
D
ALHE
RF
K
LAQ
A
AFS
S
L
ND
RTQE
S
LTS
I
--
-
-RM
I
KA
FG
-----------
LED
R
QSALFAADAEDTGKKN
M
R
VA
R
I
D
A
-
RF
DP
T
I
Y
I
AI
GM
A
N
--
LL
A
I
G
G
G
S
WMV
V
Q
GSLT
L
G
Q
LT
S
F
M
M
YLG
L
M
IW
P
M
LA
L
A
WM
FNIVERG
S
A
AY
S
R
IR
A
M
LAEA
P
V
V
N
DG
S
E
PV
PE
----
----
-
--G
RG
E
L
DV
N
IH
--
Q
FTYP
QT
D
H
PAL
E
N
V
N
F
A
L
K
P
G
QM
LGIC
G
P
TGSGKSTL
L
SLI
Q
R
H
F
D
V
S
EG
D
IR
F
HD
I
PL
TK
L
Q
L
D
S
W
R
SR
L
A
V
VSQ
T
P
F
LF
S
DTVANNIALG
-
CPNA
T
Q
Q
E
IE
H
V
AR
L
A
SVH
D
D
I
LR
L
PQ
G
Y
DT
E
V
GE
R
GV
M
LSGGQKQRI
S
IARALL
VNAE
ILILD
D
A
L
SA
V
D
GR
TE
H
Q
I
L
H
N
L
RQWG
Q
G
RT
V
I
IS
AHRLS
AL
T
E
A
S
EI
I
V
M
QH
G
H
I
AQ
RG
N
H
DV
L
A
QQS
G
W
Y
R
D
MY
R
Y
Q
QL
EAA
L
DDAPE
N
R
E
E
fig|444449.5.peg.5316
Escherichia coli O157:H7 str. EC4042 (1-586/590)
MR
L
F
A
QL
S
W
Y
FRR
E
------
W
--------
R
R
YLG
A
VALL
VI
--
-
--IA
ML
Q
L
VP
P
KVVGIVV
DG
VTEQHF
T
TGQ
I
L
M
W
I
A
TM
V
L
--
--
----
-
--
IA
VVV
Y
LLR
Y
VW
R
V
L
LFG
A
SYQ
LA
VE
LR
E
D
YYRQLS
RQ
H
P
E
F
YL
R
H
R
TG
D
L
M
A
R
A
TND
V
D
-------
R
VV
FAAGEGVL
T
L
V
-
-D
S
LV
M
G
CAV
L
I
M
M
ST
QI
SWQL
---
T
L
F
AL
L
P
M
PV
M
AI
MIKRNG
D
ALHE
RF
K
LAQ
A
AFS
S
L
ND
RTQE
S
LTS
I
--
-
-RM
I
KA
FG
-----------
LED
R
QSALFAADAEDTGKKN
M
R
VA
R
I
D
A
-
RF
DP
T
I
Y
I
AI
GM
A
N
--
LL
A
I
G
G
G
S
WMV
V
Q
GSLT
L
G
Q
LT
S
F
M
M
YLG
L
M
IW
P
M
LA
L
A
WM
FNIVERG
S
A
AY
S
R
IR
A
M
LAEA
P
V
V
N
DG
S
E
PV
PE
----
----
-
--G
RG
E
L
DV
N
IH
--
Q
FTYP
QT
D
H
PAL
E
N
V
N
F
A
L
K
P
G
QM
LGIC
G
P
TGSGKSTL
L
SLI
Q
R
H
F
D
V
S
EG
D
IR
F
HD
I
PL
TK
L
Q
L
D
S
W
R
SR
L
A
V
VSQ
T
P
F
LF
S
DTVANNIALG
-
CPNA
T
Q
Q
E
IE
H
V
AR
L
A
SVH
D
D
I
LR
L
PQ
G
Y
DT
E
V
GE
R
GV
M
LSGGQKQRI
S
IARALL
VNAE
ILILD
D
A
L
SA
V
D
GR
TE
H
Q
I
L
H
N
L
RQWG
Q
G
RT
V
I
IS
AHRLS
AL
T
E
A
S
EI
I
V
M
QH
G
H
I
AQ
RG
N
H
DV
L
A
QQS
G
W
Y
R
D
MY
R
Y
Q
QL
EAA
L
DDAPE
N
R
E
E
fig|444448.5.peg.3191
Escherichia coli O157:H7 str. EC4045 (1-586/590)
MR
L
F
A
QL
S
W
Y
FRR
E
------
W
--------
R
R
YLG
A
VALL
VI
--
-
--IA
ML
Q
L
VP
P
KVVGIVV
DG
VTEQHF
T
TGQ
I
L
M
W
I
A
TM
V
L
--
--
----
-
--
IA
VVV
Y
LLR
Y
VW
R
V
L
LFG
A
SYQ
LA
VE
LR
E
D
YYRQLS
RQ
H
P
E
F
YL
R
H
R
TG
D
L
M
A
R
A
TND
V
D
-------
R
VV
FAAGEGVL
T
L
V
-
-D
S
LV
M
G
CAV
L
I
M
M
ST
QI
SWQL
---
T
L
F
AL
L
P
M
PV
M
AI
MIKRNG
D
ALHE
RF
K
LAQ
A
AFS
S
L
ND
RTQE
S
LTS
I
--
-
-RM
I
KA
FG
-----------
LED
R
QSALFAADAEDTGKKN
M
R
VA
R
I
D
A
-
RF
DP
T
I
Y
I
AI
GM
A
N
--
LL
A
I
G
G
G
S
WMV
V
Q
GSLT
L
G
Q
LT
S
F
M
M
YLG
L
M
IW
P
M
LA
L
A
WM
FNIVERG
S
A
AY
S
R
IR
A
M
LAEA
P
V
V
N
DG
S
E
PV
PE
----
----
-
--G
RG
E
L
DV
N
IH
--
Q
FTYP
QT
D
H
PAL
E
N
V
N
F
A
L
K
P
G
QM
LGIC
G
P
TGSGKSTL
L
SLI
Q
R
H
F
D
V
S
EG
D
IR
F
HD
I
PL
TK
L
Q
L
D
S
W
R
SR
L
A
V
VSQ
T
P
F
LF
S
DTVANNIALG
-
CPNA
T
Q
Q
E
IE
H
V
AR
L
A
SVH
D
D
I
LR
L
PQ
G
Y
DT
E
V
GE
R
GV
M
LSGGQKQRI
S
IARALL
VNAE
ILILD
D
A
L
SA
V
D
GR
TE
H
Q
I
L
H
N
L
RQWG
Q
G
RT
V
I
IS
AHRLS
AL
T
E
A
S
EI
I
V
M
QH
G
H
I
AQ
RG
N
H
DV
L
A
QQS
G
W
Y
R
D
MY
R
Y
Q
QL
EAA
L
DDAPE
N
R
E
E
fig|444453.5.peg.533
Escherichia coli O157:H7 str. EC4076 (1-586/590)
MR
L
F
A
QL
S
W
Y
FRR
E
------
W
--------
R
R
YLG
A
VALL
VI
--
-
--IA
ML
Q
L
VP
P
KVVGIVV
DG
VTEQHF
T
TGQ
I
L
M
W
I
A
TM
V
L
--
--
----
-
--
IA
VVV
Y
LLR
Y
VW
R
V
L
LFG
A
SYQ
LA
VE
LR
E
D
YYRQLS
RQ
H
P
E
F
YL
R
H
R
TG
D
L
M
A
R
A
TND
V
D
-------
R
VV
FAAGEGVL
T
L
V
-
-D
S
LV
M
G
CAV
L
I
M
M
ST
QI
SWQL
---
T
L
F
AL
L
P
M
PV
M
AI
MIKRNG
D
ALHE
RF
K
LAQ
A
AFS
S
L
ND
RTQE
S
LTS
I
--
-
-RM
I
KA
FG
-----------
LED
R
QSALFAADAEDTGKKN
M
R
VA
R
I
D
A
-
RF
DP
T
I
Y
I
AI
GM
A
N
--
LL
A
I
G
G
G
S
WMV
V
Q
GSLT
L
G
Q
LT
S
F
M
M
YLG
L
M
IW
P
M
LA
L
A
WM
FNIVERG
S
A
AY
S
R
IR
A
M
LAEA
P
V
V
N
DG
S
E
PV
PE
----
----
-
--G
RG
E
L
DV
N
IH
--
Q
FTYP
QT
D
H
PAL
E
N
V
N
F
A
L
K
P
G
QM
LGIC
G
P
TGSGKSTL
L
SLI
Q
R
H
F
D
V
S
EG
D
IR
F
HD
I
PL
TK
L
Q
L
D
S
W
R
SR
L
A
V
VSQ
T
P
F
LF
S
DTVANNIALG
-
CPNA
T
Q
Q
E
IE
H
V
AR
L
A
SVH
D
D
I
LR
L
PQ
G
Y
DT
E
V
GE
R
GV
M
LSGGQKQRI
S
IARALL
VNAE
ILILD
D
A
L
SA
V
D
GR
TE
H
Q
I
L
H
N
L
RQWG
Q
G
RT
V
I
IS
AHRLS
AL
T
E
A
S
EI
I
V
M
QH
G
H
I
AQ
RG
N
H
DV
L
A
QQS
G
W
Y
R
D
MY
R
Y
Q
QL
EAA
L
DDAPE
N
R
E
E
fig|444452.5.peg.993
Escherichia coli O157:H7 str. EC4113 (1-586/590)
MR
L
F
A
QL
S
W
Y
FRR
E
------
W
--------
R
R
YLG
A
VALL
VI
--
-
--IA
ML
Q
L
VP
P
KVVGIVV
DG
VTEQHF
T
TGQ
I
L
M
W
I
A
TM
V
L
--
--
----
-
--
IA
VVV
Y
LLR
Y
VW
R
V
L
LFG
A
SYQ
LA
VE
LR
E
D
YYRQLS
RQ
H
P
E
F
YL
R
H
R
TG
D
L
M
A
R
A
TND
V
D
-------
R
VV
FAAGEGVL
T
L
V
-
-D
S
LV
M
G
CAV
L
I
M
M
ST
QI
SWQL
---
T
L
F
AL
L
P
M
PV
M
AI
MIKRNG
D
ALHE
RF
K
LAQ
A
AFS
S
L
ND
RTQE
S
LTS
I
--
-
-RM
I
KA
FG
-----------
LED
R
QSALFAADAEDTGKKN
M
R
VA
R
I
D
A
-
RF
DP
T
I
Y
I
AI
GM
A
N
--
LL
A
I
G
G
G
S
WMV
V
Q
GSLT
L
G
Q
LT
S
F
M
M
YLG
L
M
IW
P
M
LA
L
A
WM
FNIVERG
S
A
AY
S
R
IR
A
M
LAEA
P
V
V
N
DG
S
E
PV
PE
----
----
-
--G
RG
E
L
DV
N
IH
--
Q
FTYP
QT
D
H
PAL
E
N
V
N
F
A
L
K
P
G
QM
LGIC
G
P
TGSGKSTL
L
SLI
Q
R
H
F
D
V
S
EG
D
IR
F
HD
I
PL
TK
L
Q
L
D
S
W
R
SR
L
A
V
VSQ
T
P
F
LF
S
DTVANNIALG
-
CPNA
T
Q
Q
E
IE
H
V
AR
L
A
SVH
D
D
I
LR
L
PQ
G
Y
DT
E
V
GE
R
GV
M
LSGGQKQRI
S
IARALL
VNAE
ILILD
D
A
L
SA
V
D
GR
TE
H
Q
I
L
H
N
L
RQWG
Q
G
RT
V
I
IS
AHRLS
AL
T
E
A
S
EI
I
V
M
QH
G
H
I
AQ
RG
N
H
DV
L
A
QQS
G
W
Y
R
D
MY
R
Y
Q
QL
EAA
L
DDAPE
N
R
E
E
fig|444450.8.peg.653
Escherichia coli O157:H7 str. EC4115 (1-586/590)
MR
L
F
A
QL
S
W
Y
FRR
E
------
W
--------
R
R
YLG
A
VALL
VI
--
-
--IA
ML
Q
L
VP
P
KVVGIVV
DG
VTEQHF
T
TGQ
I
L
M
W
I
A
TM
V
L
--
--
----
-
--
IA
VVV
Y
LLR
Y
VW
R
V
L
LFG
A
SYQ
LA
VE
LR
E
D
YYRQLS
RQ
H
P
E
F
YL
R
H
R
TG
D
L
M
A
R
A
TND
V
D
-------
R
VV
FAAGEGVL
T
L
V
-
-D
S
LV
M
G
CAV
L
I
M
M
ST
QI
SWQL
---
T
L
F
AL
L
P
M
PV
M
AI
MIKRNG
D
ALHE
RF
K
LAQ
A
AFS
S
L
ND
RTQE
S
LTS
I
--
-
-RM
I
KA
FG
-----------
LED
R
QSALFAADAEDTGKKN
M
R
VA
R
I
D
A
-
RF
DP
T
I
Y
I
AI
GM
A
N
--
LL
A
I
G
G
G
S
WMV
V
Q
GSLT
L
G
Q
LT
S
F
M
M
YLG
L
M
IW
P
M
LA
L
A
WM
FNIVERG
S
A
AY
S
R
IR
A
M
LAEA
P
V
V
N
DG
S
E
PV
PE
----
----
-
--G
RG
E
L
DV
N
IH
--
Q
FTYP
QT
D
H
PAL
E
N
V
N
F
A
L
K
P
G
QM
LGIC
G
P
TGSGKSTL
L
SLI
Q
R
H
F
D
V
S
EG
D
IR
F
HD
I
PL
TK
L
Q
L
D
S
W
R
SR
L
A
V
VSQ
T
P
F
LF
S
DTVANNIALG
-
CPNA
T
Q
Q
E
IE
H
V
AR
L
A
SVH
D
D
I
LR
L
PQ
G
Y
DT
E
V
GE
R
GV
M
LSGGQKQRI
S
IARALL
VNAE
ILILD
D
A
L
SA
V
D
GR
TE
H
Q
I
L
H
N
L
RQWG
Q
G
RT
V
I
IS
AHRLS
AL
T
E
A
S
EI
I
V
M
QH
G
H
I
AQ
RG
N
H
DV
L
A
QQS
G
W
Y
R
D
MY
R
Y
Q
QL
EAA
L
DDAPE
N
R
E
E
fig|444451.5.peg.4617
Escherichia coli O157:H7 str. EC4196 (1-586/590)
MR
L
F
A
QL
S
W
Y
FRR
E
------
W
--------
R
R
YLG
A
VALL
VI
--
-
--IA
ML
Q
L
VP
P
KVVGIVV
DG
VTEQHF
T
TGQ
I
L
M
W
I
A
TM
V
L
--
--
----
-
--
IA
VVV
Y
LLR
Y
VW
R
V
L
LFG
A
SYQ
LA
VE
LR
E
D
YYRQLS
RQ
H
P
E
F
YL
R
H
R
TG
D
L
M
A
R
A
TND
V
D
-------
R
VV
FAAGEGVL
T
L
V
-
-D
S
LV
M
G
CAV
L
I
M
M
ST
QI
SWQL
---
T
L
F
AL
L
P
M
PV
M
AI
MIKRNG
D
ALHE
RF
K
LAQ
A
AFS
S
L
ND
RTQE
S
LTS
I
--
-
-RM
I
KA
FG
-----------
LED
R
QSALFAADAEDTGKKN
M
R
VA
R
I
D
A
-
RF
DP
T
I
Y
I
AI
GM
A
N
--
LL
A
I
G
G
G
S
WMV
V
Q
GSLT
L
G
Q
LT
S
F
M
M
YLG
L
M
IW
P
M
LA
L
A
WM
FNIVERG
S
A
AY
S
R
IR
A
M
LAEA
P
V
V
N
DG
S
E
PV
PE
----
----
-
--G
RG
E
L
DV
N
IH
--
Q
FTYP
QT
D
H
PAL
E
N
V
N
F
A
L
K
P
G
QM
LGIC
G
P
TGSGKSTL
L
SLI
Q
R
H
F
D
V
S
EG
D
IR
F
HD
I
PL
TK
L
Q
L
D
S
W
R
SR
L
A
V
VSQ
T
P
F
LF
S
DTVANNIALG
-
CPNA
T
Q
Q
E
IE
H
V
AR
L
A
SVH
D
D
I
LR
L
PQ
G
Y
DT
E
V
GE
R
GV
M
LSGGQKQRI
S
IARALL
VNAE
ILILD
D
A
L
SA
V
D
GR
TE
H
Q
I
L
H
N
L
RQWG
Q
G
RT
V
I
IS
AHRLS
AL
T
E
A
S
EI
I
V
M
QH
G
H
I
AQ
RG
N
H
DV
L
A
QQS
G
W
Y
R
D
MY
R
Y
Q
QL
EAA
L
DDAPE
N
R
E
E
fig|444447.5.peg.3365
Escherichia coli O157:H7 str. EC4206 (1-586/590)
MR
L
F
A
QL
S
W
Y
FRR
E
------
W
--------
R
R
YLG
A
VALL
VI
--
-
--IA
ML
Q
L
VP
P
KVVGIVV
DG
VTEQHF
T
TGQ
I
L
M
W
I
A
TM
V
L
--
--
----
-
--
IA
VVV
Y
LLR
Y
VW
R
V
L
LFG
A
SYQ
LA
VE
LR
E
D
YYRQLS
RQ
H
P
E
F
YL
R
H
R
TG
D
L
M
A
R
A
TND
V
D
-------
R
VV
FAAGEGVL
T
L
V
-
-D
S
LV
M
G
CAV
L
I
M
M
ST
QI
SWQL
---
T
L
F
AL
L
P
M
PV
M
AI
MIKRNG
D
ALHE
RF
K
LAQ
A
AFS
S
L
ND
RTQE
S
LTS
I
--
-
-RM
I
KA
FG
-----------
LED
R
QSALFAADAEDTGKKN
M
R
VA
R
I
D
A
-
RF
DP
T
I
Y
I
AI
GM
A
N
--
LL
A
I
G
G
G
S
WMV
V
Q
GSLT
L
G
Q
LT
S
F
M
M
YLG
L
M
IW
P
M
LA
L
A
WM
FNIVERG
S
A
AY
S
R
IR
A
M
LAEA
P
V
V
N
DG
S
E
PV
PE
----
----
-
--G
RG
E
L
DV
N
IH
--
Q
FTYP
QT
D
H
PAL
E
N
V
N
F
A
L
K
P
G
QM
LGIC
G
P
TGSGKSTL
L
SLI
Q
R
H
F
D
V
S
EG
D
IR
F
HD
I
PL
TK
L
Q
L
D
S
W
R
SR
L
A
V
VSQ
T
P
F
LF
S
DTVANNIALG
-
CPNA
T
Q
Q
E
IE
H
V
AR
L
A
SVH
D
D
I
LR
L
PQ
G
Y
DT
E
V
GE
R
GV
M
LSGGQKQRI
S
IARALL
VNAE
ILILD
D
A
L
SA
V
D
GR
TE
H
Q
I
L
H
N
L
RQWG
Q
G
RT
V
I
IS
AHRLS
AL
T
E
A
S
EI
I
V
M
QH
G
H
I
AQ
RG
N
H
DV
L
A
QQS
G
W
Y
R
D
MY
R
Y
Q
QL
EAA
L
DDAPE
N
R
E
E
fig|478004.5.peg.1361
Escherichia coli O157:H7 str. EC4401 (1-586/590)
MR
L
F
A
QL
S
W
Y
FRR
E
------
W
--------
R
R
YLG
A
VALL
VI
--
-
--IA
ML
Q
L
VP
P
KVVGIVV
DG
VTEQHF
T
TGQ
I
L
M
W
I
A
TM
V
L
--
--
----
-
--
IA
VVV
Y
LLR
Y
VW
R
V
L
LFG
A
SYQ
LA
VE
LR
E
D
YYRQLS
RQ
H
P
E
F
YL
R
H
R
TG
D
L
M
A
R
A
TND
V
D
-------
R
VV
FAAGEGVL
T
L
V
-
-D
S
LV
M
G
CAV
L
I
M
M
ST
QI
SWQL
---
T
L
F
AL
L
P
M
PV
M
AI
MIKRNG
D
ALHE
RF
K
LAQ
A
AFS
S
L
ND
RTQE
S
LTS
I
--
-
-RM
I
KA
FG
-----------
LED
R
QSALFAADAEDTGKKN
M
R
VA
R
I
D
A
-
RF
DP
T
I
Y
I
AI
GM
A
N
--
LL
A
I
G
G
G
S
WMV
V
Q
GSLT
L
G
Q
LT
S
F
M
M
YLG
L
M
IW
P
M
LA
L
A
WM
FNIVERG
S
A
AY
S
R
IR
A
M
LAEA
P
V
V
N
DG
S
E
PV
PE
----
----
-
--G
RG
E
L
DV
N
IH
--
Q
FTYP
QT
D
H
PAL
E
N
V
N
F
A
L
K
P
G
QM
LGIC
G
P
TGSGKSTL
L
SLI
Q
R
H
F
D
V
S
EG
D
IR
F
HD
I
PL
TK
L
Q
L
D
S
W
R
SR
L
A
V
VSQ
T
P
F
LF
S
DTVANNIALG
-
CPNA
T
Q
Q
E
IE
H
V
AR
L
A
SVH
D
D
I
LR
L
PQ
G
Y
DT
E
V
GE
R
GV
M
LSGGQKQRI
S
IARALL
VNAE
ILILD
D
A
L
SA
V
D
GR
TE
H
Q
I
L
H
N
L
RQWG
Q
G
RT
V
I
IS
AHRLS
AL
T
E
A
S
EI
I
V
M
QH
G
H
I
AQ
RG
N
H
DV
L
A
QQS
G
W
Y
R
D
MY
R
Y
Q
QL
EAA
L
DDAPE
N
R
E
E
fig|478006.5.peg.954
Escherichia coli O157:H7 str. EC4501 (1-586/590)
MR
L
F
A
QL
S
W
Y
FRR
E
------
W
--------
R
R
YLG
A
VALL
VI
--
-
--IA
ML
Q
L
VP
P
KVVGIVV
DG
VTEQHF
T
TGQ
I
L
M
W
I
A
TM
V
L
--
--
----
-
--
IA
VVV
Y
LLR
Y
VW
R
V
L
LFG
A
SYQ
LA
VE
LR
E
D
YYRQLS
RQ
H
P
E
F
YL
R
H
R
TG
D
L
M
A
R
A
TND
V
D
-------
R
VV
FAAGEGVL
T
L
V
-
-D
S
LV
M
G
CAV
L
I
M
M
ST
QI
SWQL
---
T
L
F
AL
L
P
M
PV
M
AI
MIKRNG
D
ALHE
RF
K
LAQ
A
AFS
S
L
ND
RTQE
S
LTS
I
--
-
-RM
I
KA
FG
-----------
LED
R
QSALFAADAEDTGKKN
M
R
VA
R
I
D
A
-
RF
DP
T
I
Y
I
AI
GM
A
N
--
LL
A
I
G
G
G
S
WMV
V
Q
GSLT
L
G
Q
LT
S
F
M
M
YLG
L
M
IW
P
M
LA
L
A
WM
FNIVERG
S
A
AY
S
R
IR
A
M
LAEA
P
V
V
N
DG
S
E
PV
PE
----
----
-
--G
RG
E
L
DV
N
IH
--
Q
FTYP
QT
D
H
PAL
E
N
V
N
F
A
L
K
P
G
QM
LGIC
G
P
TGSGKSTL
L
SLI
Q
R
H
F
D
V
S
EG
D
IR
F
HD
I
PL
TK
L
Q
L
D
S
W
R
SR
L
A
V
VSQ
T
P
F
LF
S
DTVANNIALG
-
CPNA
T
Q
Q
E
IE
H
V
AR
L
A
SVH
D
D
I
LR
L
PQ
G
Y
DT
E
V
GE
R
GV
M
LSGGQKQRI
S
IARALL
VNAE
ILILD
D
A
L
SA
V
D
GR
TE
H
Q
I
L
H
N
L
RQWG
Q
G
RT
V
I
IS
AHRLS
AL
T
E
A
S
EI
I
V
M
QH
G
H
I
AQ
RG
N
H
DV
L
A
QQS
G
W
Y
R
D
MY
R
Y
Q
QL
EAA
L
DDAPE
N
R
E
E
fig|478007.5.peg.851
Escherichia coli O157:H7 str. EC508 (1-586/590)
MR
L
F
A
QL
S
W
Y
FRR
E
------
W
--------
R
R
YLG
A
VALL
VI
--
-
--IA
ML
Q
L
VP
P
KVVGIVV
DG
VTEQHF
T
TGQ
I
L
M
W
I
A
TM
V
L
--
--
----
-
--
IA
VVV
Y
LLR
Y
VW
R
V
L
LFG
A
SYQ
LA
VE
LR
E
D
YYRQLS
RQ
H
P
E
F
YL
R
H
R
TG
D
L
M
A
R
A
TND
V
D
-------
R
VV
FAAGEGVL
T
L
V
-
-D
S
LV
M
G
CAV
L
I
M
M
ST
QI
SWQL
---
T
L
F
AL
L
P
M
PV
M
AI
MIKRNG
D
ALHE
RF
K
LAQ
A
AFS
S
L
ND
RTQE
S
LTS
I
--
-
-RM
I
KA
FG
-----------
LED
R
QSALFAADAEDTGKKN
M
R
VA
R
I
D
A
-
RF
DP
T
I
Y
I
AI
GM
A
N
--
LL
A
I
G
G
G
S
WMV
V
Q
GSLT
L
G
Q
LT
S
F
M
M
YLG
L
M
IW
P
M
LA
L
A
WM
FNIVERG
S
A
AY
S
R
IR
A
M
LAEA
P
V
V
N
DG
S
E
PV
PE
----
----
-
--G
RG
E
L
DV
N
IH
--
Q
FTYP
QT
D
H
PAL
E
N
V
N
F
A
L
K
P
G
QM
LGIC
G
P
TGSGKSTL
L
SLI
Q
R
H
F
D
V
S
EG
D
IR
F
HD
I
PL
TK
L
Q
L
D
S
W
R
SR
L
A
V
VSQ
T
P
F
LF
S
DTVANNIALG
-
CPNA
T
Q
Q
E
IE
H
V
AR
L
A
SVH
D
D
I
LR
L
PQ
G
Y
DT
E
V
GE
R
GV
M
LSGGQKQRI
S
IARALL
VNAE
ILILD
D
A
L
SA
V
D
GR
TE
H
Q
I
L
H
N
L
RQWG
Q
G
RT
V
I
IS
AHRLS
AL
T
E
A
S
EI
I
V
M
QH
G
H
I
AQ
RG
N
H
DV
L
A
QQS
G
W
Y
R
D
MY
R
Y
Q
QL
EAA
L
DDAPE
N
R
E
E
fig|478008.5.peg.1593
Escherichia coli O157:H7 str. EC869 (1-586/590)
MR
L
F
A
QL
S
W
Y
FRR
E
------
W
--------
R
R
YLG
A
VALL
VI
--
-
--IA
ML
Q
L
VP
P
KVVGIVV
DG
VTEQHF
T
TGQ
I
L
M
W
I
A
TM
V
L
--
--
----
-
--
IA
VVV
Y
LLR
Y
VW
R
V
L
LFG
A
SYQ
LA
VE
LR
E
D
YYRQLS
RQ
H
P
E
F
YL
R
H
R
TG
D
L
M
A
R
A
TND
V
D
-------
R
VV
FAAGEGVL
T
L
V
-
-D
S
LV
M
G
CAV
L
I
M
M
ST
QI
SWQL
---
T
L
F
AL
L
P
M
PV
M
AI
MIKRNG
D
ALHE
RF
K
LAQ
A
AFS
S
L
ND
RTQE
S
LTS
I
--
-
-RM
I
KA
FG
-----------
LED
R
QSALFAADAEDTGKKN
M
R
VA
R
I
D
A
-
RF
DP
T
I
Y
I
AI
GM
A
N
--
LL
A
I
G
G
G
S
WMV
V
Q
GSLT
L
G
Q
LT
S
F
M
M
YLG
L
M
IW
P
M
LA
L
A
WM
FNIVERG
S
A
AY
S
R
IR
A
M
LAEA
P
V
V
N
DG
S
E
PV
PE
----
----
-
--G
RG
E
L
DV
N
IH
--
Q
FTYP
QT
D
H
PAL
E
N
V
N
F
A
L
K
P
G
QM
LGIC
G
P
TGSGKSTL
L
SLI
Q
R
H
F
D
V
S
EG
D
IR
F
HD
I
PL
TK
L
Q
L
D
S
W
R
SR
L
A
V
VSQ
T
P
F
LF
S
DTVANNIALG
-
CPNA
T
Q
Q
E
IE
H
V
AR
L
A
SVH
D
D
I
LR
L
PQ
G
Y
DT
E
V
GE
R
GV
M
LSGGQKQRI
S
IARALL
VNAE
ILILD
D
A
L
SA
V
D
GR
TE
H
Q
I
L
H
N
L
RQWG
Q
G
RT
V
I
IS
AHRLS
AL
T
E
A
S
EI
I
V
M
QH
G
H
I
AQ
RG
N
H
DV
L
A
QQS
G
W
Y
R
D
MY
R
Y
Q
QL
EAA
L
DDAPE
N
R
E
E
fig|637388.3.peg.989
Escherichia coli O157:H7 str. FRIK2000 (1-586/590)
MR
L
F
A
QL
S
W
Y
FRR
E
------
W
--------
R
R
YLG
A
VALL
VI
--
-
--IA
ML
Q
L
VP
P
KVVGIVV
DG
VTEQHF
T
TGQ
I
L
M
W
I
A
TM
V
L
--
--
----
-
--
IA
VVV
Y
LLR
Y
VW
R
V
L
LFG
A
SYQ
LA
VE
LR
E
D
YYRQLS
RQ
H
P
E
F
YL
R
H
R
TG
D
L
M
A
R
A
TND
V
D
-------
R
VV
FAAGEGVL
T
L
V
-
-D
S
LV
M
G
CAV
L
I
M
M
ST
QI
SWQL
---
T
L
F
AL
L
P
M
PV
M
AI
MIKRNG
D
ALHE
RF
K
LAQ
A
AFS
S
L
ND
RTQE
S
LTS
I
--
-
-RM
I
KA
FG
-----------
LED
R
QSALFAADAEDTGKKN
M
R
VA
R
I
D
A
-
RF
DP
T
I
Y
I
AI
GM
A
N
--
LL
A
I
G
G
G
S
WMV
V
Q
GSLT
L
G
Q
LT
S
F
M
M
YLG
L
M
IW
P
M
LA
L
A
WM
FNIVERG
S
A
AY
S
R
IR
A
M
LAEA
P
V
V
N
DG
S
E
PV
PE
----
----
-
--G
RG
E
L
DV
N
IH
--
Q
FTYP
QT
D
H
PAL
E
N
V
N
F
A
L
K
P
G
QM
LGIC
G
P
TGSGKSTL
L
SLI
Q
R
H
F
D
V
S
EG
D
IR
F
HD
I
PL
TK
L
Q
L
D
S
W
R
SR
L
A
V
VSQ
T
P
F
LF
S
DTVANNIALG
-
CPNA
T
Q
Q
E
IE
H
V
AR
L
A
SVH
D
D
I
LR
L
PQ
G
Y
DT
E
V
GE
R
GV
M
LSGGQKQRI
S
IARALL
VNAE
ILILD
D
A
L
SA
V
D
GR
TE
H
Q
I
L
H
N
L
RQWG
Q
G
RT
V
I
IS
AHRLS
AL
T
E
A
S
EI
I
V
M
QH
G
H
I
AQ
RG
N
H
DV
L
A
QQS
G
W
Y
R
D
MY
R
Y
Q
QL
EAA
L
DDAPE
N
R
E
E
fig|570506.3.peg.2221
Escherichia coli O157:H7 str. FRIK966 (1-586/590)
MR
L
F
A
QL
S
W
Y
FRR
E
------
W
--------
R
R
YLG
A
VALL
VI
--
-
--IA
ML
Q
L
VP
P
KVVGIVV
DG
VTEQHF
T
TGQ
I
L
M
W
I
A
TM
V
L
--
--
----
-
--
IA
VVV
Y
LLR
Y
VW
R
V
L
LFG
A
SYQ
LA
VE
LR
E
D
YYRQLS
RQ
H
P
E
F
YL
R
H
R
TG
D
L
M
A
R
A
TND
V
D
-------
R
VV
FAAGEGVL
T
L
V
-
-D
S
LV
M
G
CAV
L
I
M
M
ST
QI
SWQL
---
T
L
F
AL
L
P
M
PV
M
AI
MIKRNG
D
ALHE
RF
K
LAQ
A
AFS
S
L
ND
RTQE
S
LTS
I
--
-
-RM
I
KA
FG
-----------
LED
R
QSALFAADAEDTGKKN
M
R
VA
R
I
D
A
-
RF
DP
T
I
Y
I
AI
GM
A
N
--
LL
A
I
G
G
G
S
WMV
V
Q
GSLT
L
G
Q
LT
S
F
M
M
YLG
L
M
IW
P
M
LA
L
A
WM
FNIVERG
S
A
AY
S
R
IR
A
M
LAEA
P
V
V
N
DG
S
E
PV
PE
----
----
-
--G
RG
E
L
DV
N
IH
--
Q
FTYP
QT
D
H
PAL
E
N
V
N
F
A
L
K
P
G
QM
LGIC
G
P
TGSGKSTL
L
SLI
Q
R
H
F
D
V
S
EG
D
IR
F
HD
I
PL
TK
L
Q
L
D
S
W
R
SR
L
A
V
VSQ
T
P
F
LF
S
DTVANNIALG
-
CPNA
T
Q
Q
E
IE
H
V
AR
L
A
SVH
D
D
I
LR
L
PQ
G
Y
DT
E
V
GE
R
GV
M
LSGGQKQRI
S
IARALL
VNAE
ILILD
D
A
L
SA
V
D
GR
TE
H
Q
I
L
H
N
L
RQWG
Q
G
RT
V
I
IS
AHRLS
AL
T
E
A
S
EI
I
V
M
QH
G
H
I
AQ
RG
N
H
DV
L
A
QQS
G
W
Y
R
D
MY
R
Y
Q
QL
EAA
L
DDAPE
N
R
E
E
fig|386585.9.peg.606
Escherichia coli O157:H7 str. Sakai (1-586/590)
MR
L
F
A
QL
S
W
Y
FRR
E
------
W
--------
R
R
YLG
A
VALL
VI
--
-
--IA
ML
Q
L
VP
P
KVVGIVV
DG
VTEQHF
T
TGQ
I
L
M
W
I
A
TM
V
L
--
--
----
-
--
IA
VVV
Y
LLR
Y
VW
R
V
L
LFG
A
SYQ
LA
VE
LR
E
D
YYRQLS
RQ
H
P
E
F
YL
R
H
R
TG
D
L
M
A
R
A
TND
V
D
-------
R
VV
FAAGEGVL
T
L
V
-
-D
S
LV
M
G
CAV
L
I
M
M
ST
QI
SWQL
---
T
L
F
AL
L
P
M
PV
M
AI
MIKRNG
D
ALHE
RF
K
LAQ
A
AFS
S
L
ND
RTQE
S
LTS
I
--
-
-RM
I
KA
FG
-----------
LED
R
QSALFAADAEDTGKKN
M
R
VA
R
I
D
A
-
RF
DP
T
I
Y
I
AI
GM
A
N
--
LL
A
I
G
G
G
S
WMV
V
Q
GSLT
L
G
Q
LT
S
F
M
M
YLG
L
M
IW
P
M
LA
L
A
WM
FNIVERG
S
A
AY
S
R
IR
A
M
LAEA
P
V
V
N
DG
S
E
PV
PE
----
----
-
--G
RG
E
L
DV
N
IH
--
Q
FTYP
QT
D
H
PAL
E
N
V
N
F
A
L
K
P
G
QM
LGIC
G
P
TGSGKSTL
L
SLI
Q
R
H
F
D
V
S
EG
D
IR
F
HD
I
PL
TK
L
Q
L
D
S
W
R
SR
L
A
V
VSQ
T
P
F
LF
S
DTVANNIALG
-
CPNA
T
Q
Q
E
IE
H
V
AR
L
A
SVH
D
D
I
LR
L
PQ
G
Y
DT
E
V
GE
R
GV
M
LSGGQKQRI
S
IARALL
VNAE
ILILD
D
A
L
SA
V
D
GR
TE
H
Q
I
L
H
N
L
RQWG
Q
G
RT
V
I
IS
AHRLS
AL
T
E
A
S
EI
I
V
M
QH
G
H
I
AQ
RG
N
H
DV
L
A
QQS
G
W
Y
R
D
MY
R
Y
Q
QL
EAA
L
DDAPE
N
R
E
E
fig|544404.4.peg.518
Escherichia coli O157:H7 str. TW14359 (1-586/590)
MR
L
F
A
QL
S
W
Y
FRR
E
------
W
--------
R
R
YLG
A
VALL
VI
--
-
--IA
ML
Q
L
VP
P
KVVGIVV
DG
VTEQHF
T
TGQ
I
L
M
W
I
A
TM
V
L
--
--
----
-
--
IA
VVV
Y
LLR
Y
VW
R
V
L
LFG
A
SYQ
LA
VE
LR
E
D
YYRQLS
RQ
H
P
E
F
YL
R
H
R
TG
D
L
M
A
R
A
TND
V
D
-------
R
VV
FAAGEGVL
T
L
V
-
-D
S
LV
M
G
CAV
L
I
M
M
ST
QI
SWQL
---
T
L
F
AL
L
P
M
PV
M
AI
MIKRNG
D
ALHE
RF
K
LAQ
A
AFS
S
L
ND
RTQE
S
LTS
I
--
-
-RM
I
KA
FG
-----------
LED
R
QSALFAADAEDTGKKN
M
R
VA
R
I
D
A
-
RF
DP
T
I
Y
I
AI
GM
A
N
--
LL
A
I
G
G
G
S
WMV
V
Q
GSLT
L
G
Q
LT
S
F
M
M
YLG
L
M
IW
P
M
LA
L
A
WM
FNIVERG
S
A
AY
S
R
IR
A
M
LAEA
P
V
V
N
DG
S
E
PV
PE
----
----
-
--G
RG
E
L
DV
N
IH
--
Q
FTYP
QT
D
H
PAL
E
N
V
N
F
A
L
K
P
G
QM
LGIC
G
P
TGSGKSTL
L
SLI
Q
R
H
F
D
V
S
EG
D
IR
F
HD
I
PL
TK
L
Q
L
D
S
W
R
SR
L
A
V
VSQ
T
P
F
LF
S
DTVANNIALG
-
CPNA
T
Q
Q
E
IE
H
V
AR
L
A
SVH
D
D
I
LR
L
PQ
G
Y
DT
E
V
GE
R
GV
M
LSGGQKQRI
S
IARALL
VNAE
ILILD
D
A
L
SA
V
D
GR
TE
H
Q
I
L
H
N
L
RQWG
Q
G
RT
V
I
IS
AHRLS
AL
T
E
A
S
EI
I
V
M
QH
G
H
I
AQ
RG
N
H
DV
L
A
QQS
G
W
Y
R
D
MY
R
Y
Q
QL
EAA
L
DDAPE
N
R
E
E
fig|502346.5.peg.706
Escherichia coli O157:H7 str. TW14588 (1-586/590)
MR
L
F
A
QL
S
W
Y
FRR
E
------
W
--------
R
R
YLG
A
VALL
VI
--
-
--IA
ML
Q
L
VP
P
KVVGIVV
DG
VTEQHF
T
TGQ
I
L
M
W
I
A
TM
V
L
--
--
----
-
--
IA
VVV
Y
LLR
Y
VW
R
V
L
LFG
A
SYQ
LA
VE
LR
E
D
YYRQLS
RQ
H
P
E
F
YL
R
H
R
TG
D
L
M
A
R
A
TND
V
D
-------
R
VV
FAAGEGVL
T
L
V
-
-D
S
LV
M
G
CAV
L
I
M
M
ST
QI
SWQL
---
T
L
F
AL
L
P
M
PV
M
AI
MIKRNG
D
ALHE
RF
K
LAQ
A
AFS
S
L
ND
RTQE
S
LTS
I
--
-
-RM
I
KA
FG
-----------
LED
R
QSALFAADAEDTGKKN
M
R
VA
R
I
D
A
-
RF
DP
T
I
Y
I
AI
GM
A
N
--
LL
A
I
G
G
G
S
WMV
V
Q
GSLT
L
G
Q
LT
S
F
M
M
YLG
L
M
IW
P
M
LA
L
A
WM
FNIVERG
S
A
AY
S
R
IR
A
M
LAEA
P
V
V
N
DG
S
E
PV
PE
----
----
-
--G
RG
E
L
DV
N
IH
--
Q
FTYP
QT
D
H
PAL
E
N
V
N
F
A
L
K
P
G
QM
LGIC
G
P
TGSGKSTL
L
SLI
Q
R
H
F
D
V
S
EG
D
IR
F
HD
I
PL
TK
L
Q
L
D
S
W
R
SR
L
A
V
VSQ
T
P
F
LF
S
DTVANNIALG
-
CPNA
T
Q
Q
E
IE
H
V
AR
L
A
SVH
D
D
I
LR
L
PQ
G
Y
DT
E
V
GE
R
GV
M
LSGGQKQRI
S
IARALL
VNAE
ILILD
D
A
L
SA
V
D
GR
TE
H
Q
I
L
H
N
L
RQWG
Q
G
RT
V
I
IS
AHRLS
AL
T
E
A
S
EI
I
V
M
QH
G
H
I
AQ
RG
N
H
DV
L
A
QQS
G
W
Y
R
D
MY
R
Y
Q
QL
EAA
L
DDAPE
N
R
E
E
fig|701177.3.peg.558
Escherichia coli O55:H7 str. CB9615 (1-586/590)
MR
L
F
A
QL
S
W
Y
FRR
E
------
W
--------
R
R
YLG
A
VALL
VI
--
-
--IA
ML
Q
L
VP
P
KVVGIVV
DG
VTEQHF
T
TGQ
I
L
M
W
I
A
TM
V
L
--
--
----
-
--
IA
VVV
Y
LLR
Y
VW
R
V
L
LFG
A
SYQ
LA
VE
LR
E
D
YYRQLS
RQ
H
P
E
F
YL
R
H
R
TG
D
L
M
A
R
A
TND
V
D
-------
R
VV
FAAGEGVL
T
L
V
-
-D
S
LV
M
G
CAV
L
I
M
M
ST
QI
SWQL
---
T
L
F
AL
L
P
M
PV
M
AI
MIKRNG
D
ALHE
RF
K
LAQ
A
AFS
S
L
ND
RTQE
S
LTS
I
--
-
-RM
I
KA
FG
-----------
LED
R
QSALFAADAEDTGKKN
M
R
VA
R
I
D
A
-
RF
DP
T
I
Y
I
AI
GM
A
N
--
LL
A
I
G
G
G
S
WMV
V
Q
GSLT
L
G
Q
LT
S
F
M
M
YLG
L
M
IW
P
M
LA
L
A
WM
FNIVERG
S
A
AY
S
R
IR
A
M
LAEA
P
V
V
N
DG
S
E
PV
PE
----
----
-
--G
RG
E
L
DV
N
IH
--
Q
FTYP
QT
D
H
PAL
E
N
V
N
F
A
L
K
P
G
QM
LGIC
G
P
TGSGKSTL
L
SLI
Q
R
H
F
D
V
S
EG
D
IR
F
HD
I
PL
TK
L
Q
L
D
S
W
R
SR
L
A
V
VSQ
T
P
F
LF
S
DTVANNIALG
-
CPNA
T
Q
Q
E
IE
H
V
AR
L
A
SVH
D
D
I
LR
L
PQ
G
Y
DT
E
V
GE
R
GV
M
LSGGQKQRI
S
IARALL
VNAE
ILILD
D
A
L
SA
V
D
GR
TE
H
Q
I
L
H
N
L
RQWG
Q
G
RT
V
I
IS
AHRLS
AL
T
E
A
S
EI
I
V
M
QH
G
H
I
AQ
RG
N
H
DV
L
A
QQS
G
W
Y
R
D
MY
R
Y
Q
QL
EAA
L
DDAPE
N
R
E
E
fig|585034.4.peg.447
Escherichia coli IAI1 (1-586/590)
MR
L
F
A
QL
S
W
Y
FRR
E
------
W
--------
R
R
YLG
A
VALL
VI
--
-
--IA
ML
Q
L
VP
P
KVVGIVV
DG
VTEQHF
T
TGQ
I
L
M
W
I
A
TM
V
L
--
--
----
-
--
IA
VVV
Y
LLR
Y
VW
R
V
L
LFG
A
SYQ
LA
VE
LR
E
D
YYRQLS
RQ
H
P
E
F
YL
R
H
R
TG
D
L
M
A
R
A
TND
V
D
-------
R
VV
FAAGEGVL
T
L
V
-
-D
S
LV
M
G
CAV
L
I
M
M
ST
QI
SWQL
---
T
L
F
AL
L
P
M
PV
M
AI
MIKRNG
D
ALHE
RF
K
LAQ
A
AFS
S
L
ND
RTQE
S
LTS
I
--
-
-RM
I
KA
FG
-----------
LED
R
QSALFAADAEDTGKKN
M
R
VA
R
I
D
A
-
RF
DP
T
I
Y
I
AI
GM
A
N
--
LL
A
I
G
G
G
S
WMV
V
Q
GSLT
L
G
Q
LT
S
F
M
M
YLG
L
M
IW
P
M
LA
L
A
WM
FNIVERG
S
A
AY
S
R
IR
A
M
LAEA
P
V
V
N
DG
S
E
PV
PE
----
----
-
--G
RG
E
L
DV
N
IH
--
Q
FTYP
QT
D
H
PAL
E
N
V
N
F
A
L
K
P
G
QM
LGIC
G
P
TGSGKSTL
L
SLI
Q
R
H
F
D
V
S
EG
D
IR
F
HD
I
PL
TK
L
Q
L
D
S
W
R
SR
L
A
V
VSQ
A
P
F
LF
S
DTVANNIALG
-
CPNA
T
Q
Q
E
IE
H
V
AR
L
A
SVH
D
D
I
LR
L
PQ
G
Y
DT
E
V
GE
R
GV
M
LSGGQKQRI
S
IARALL
VNAE
ILILD
D
A
L
SA
V
D
GR
TE
H
Q
I
L
H
N
L
RQWG
Q
G
RT
V
I
IS
AHRLS
AL
T
E
A
S
EI
I
V
M
QH
G
H
I
AQ
RG
N
H
DV
L
A
QQS
G
W
Y
R
D
MY
R
Y
Q
QL
EAA
L
DDAPE
N
R
E
E
fig|585034.5.peg.446
Escherichia coli IAI1 (1-586/590)
MR
L
F
A
QL
S
W
Y
FRR
E
------
W
--------
R
R
YLG
A
VALL
VI
--
-
--IA
ML
Q
L
VP
P
KVVGIVV
DG
VTEQHF
T
TGQ
I
L
M
W
I
A
TM
V
L
--
--
----
-
--
IA
VVV
Y
LLR
Y
VW
R
V
L
LFG
A
SYQ
LA
VE
LR
E
D
YYRQLS
RQ
H
P
E
F
YL
R
H
R
TG
D
L
M
A
R
A
TND
V
D
-------
R
VV
FAAGEGVL
T
L
V
-
-D
S
LV
M
G
CAV
L
I
M
M
ST
QI
SWQL
---
T
L
F
AL
L
P
M
PV
M
AI
MIKRNG
D
ALHE
RF
K
LAQ
A
AFS
S
L
ND
RTQE
S
LTS
I
--
-
-RM
I
KA
FG
-----------
LED
R
QSALFAADAEDTGKKN
M
R
VA
R
I
D
A
-
RF
DP
T
I
Y
I
AI
GM
A
N
--
LL
A
I
G
G
G
S
WMV
V
Q
GSLT
L
G
Q
LT
S
F
M
M
YLG
L
M
IW
P
M
LA
L
A
WM
FNIVERG
S
A
AY
S
R
IR
A
M
LAEA
P
V
V
N
DG
S
E
PV
PE
----
----
-
--G
RG
E
L
DV
N
IH
--
Q
FTYP
QT
D
H
PAL
E
N
V
N
F
A
L
K
P
G
QM
LGIC
G
P
TGSGKSTL
L
SLI
Q
R
H
F
D
V
S
EG
D
IR
F
HD
I
PL
TK
L
Q
L
D
S
W
R
SR
L
A
V
VSQ
A
P
F
LF
S
DTVANNIALG
-
CPNA
T
Q
Q
E
IE
H
V
AR
L
A
SVH
D
D
I
LR
L
PQ
G
Y
DT
E
V
GE
R
GV
M
LSGGQKQRI
S
IARALL
VNAE
ILILD
D
A
L
SA
V
D
GR
TE
H
Q
I
L
H
N
L
RQWG
Q
G
RT
V
I
IS
AHRLS
AL
T
E
A
S
EI
I
V
M
QH
G
H
I
AQ
RG
N
H
DV
L
A
QQS
G
W
Y
R
D
MY
R
Y
Q
QL
EAA
L
DDAPE
N
R
E
E
fig|536056.3.peg.3341
Escherichia coli DH1 (1-586/590)
MR
L
F
A
QL
S
W
Y
FRR
E
------
W
--------
R
R
YLG
A
VALL
VI
--
-
--IA
ML
Q
L
VP
P
KVVGIVV
DG
VTEQHF
T
TGQ
I
L
M
W
I
A
TM
V
L
--
--
----
-
--
IA
VVV
Y
LLR
Y
VW
R
V
L
LFG
A
SYQ
LA
VE
LR
E
D
YYRQLS
RQ
H
P
E
F
YL
R
H
R
TG
D
L
M
A
R
A
TND
V
D
-------
R
VV
FAAGEEVL
T
L
V
-
-D
S
LV
M
G
CAV
L
I
M
M
ST
QI
SWQL
---
T
L
F
S
L
L
P
M
PV
M
AI
MIKRNG
D
ALHE
RF
K
LAQ
A
AFS
S
L
ND
RTQE
S
LTS
I
--
-
-RM
I
KA
FG
-----------
LED
R
QSALFAADAEDTGKKN
M
R
VA
R
I
D
A
-
RF
DP
T
I
Y
I
AI
GM
A
N
--
LL
A
I
G
G
G
S
WMV
V
Q
GSLT
L
G
Q
LT
S
F
M
M
YLG
L
M
IW
P
M
LA
L
A
WM
FNIVERG
S
A
AY
S
R
IR
A
M
LAEA
P
V
V
N
DG
S
E
PV
PE
----
----
-
--G
RG
E
L
DV
N
IH
--
Q
FTYP
QT
D
H
PAL
E
N
V
N
F
A
L
K
P
G
QM
LGIC
G
P
TGSGKSTL
L
SLI
Q
R
H
F
D
V
S
EG
D
IR
F
HD
I
PL
TK
L
Q
L
D
S
W
R
SR
L
A
V
VSQ
T
P
F
LF
S
DTVANNIALG
-
CPNA
T
Q
Q
E
IE
H
V
AR
L
A
SVH
D
D
I
LR
L
PQ
G
Y
DT
E
V
GE
R
GV
M
LSGGQKQRI
S
IARALL
VNAE
ILILD
D
A
L
SA
V
D
GR
TE
H
Q
I
L
H
N
L
RQWG
Q
G
RT
V
I
IS
AHRLS
AL
T
E
A
S
EI
I
V
M
QH
G
H
I
AQ
RG
N
H
DV
L
A
QQS
G
W
Y
R
D
MY
R
Y
Q
QL
EAA
L
DDAPE
N
R
E
E
fig|595496.3.peg.369
Escherichia coli BW2952 (1-586/590)
MR
L
F
A
QL
S
W
Y
FRR
E
------
W
--------
R
R
YLG
A
VALL
VI
--
-
--IA
ML
Q
L
VP
P
KVVGIVV
DG
VTEQHF
T
TGQ
I
L
M
W
I
A
TM
V
L
--
--
----
-
--
IA
VVV
Y
LLR
Y
VW
R
V
L
LFG
A
SYQ
LA
VE
LR
E
D
YYRQLS
RQ
H
P
E
F
YL
R
H
R
TG
D
L
M
A
R
A
TND
V
D
-------
R
VV
FAAGEGVL
T
L
V
-
-D
S
LV
M
G
CAV
L
I
M
M
ST
QI
SWQL
---
T
L
F
S
L
L
P
M
PV
M
AI
MIKRNG
D
ALHE
RF
K
LAQ
A
AFS
S
L
ND
RTQE
S
LTS
I
--
-
-RM
I
KA
FG
-----------
LED
R
QSALFAADAEDTGKKN
M
R
VA
R
I
D
A
-
RF
DP
T
I
Y
I
AI
GM
A
N
--
LL
A
I
G
G
G
S
WMV
V
Q
GSLT
L
G
Q
LT
S
F
M
M
YLG
L
M
IW
P
M
LA
L
A
WM
FNIVERG
S
A
AY
S
R
IR
A
M
LAEA
P
V
V
N
DG
S
E
PV
PE
----
----
-
--G
RG
E
L
DV
N
IH
--
Q
FTYP
QT
D
H
PAL
E
N
V
N
F
A
L
K
P
G
QM
LGIC
G
P
TGSGKSTL
L
SLI
Q
R
H
F
D
V
S
EG
D
IR
F
HD
I
PL
TK
L
Q
L
D
S
W
R
SR
L
A
V
VSQ
T
P
F
LF
S
DTVANNIALG
-
CPNA
T
Q
Q
E
IE
H
V
AR
L
A
SVH
D
D
I
LR
L
PQ
G
Y
DT
E
V
GE
R
GV
M
LSGGQKQRI
S
IARALL
VNAE
ILILD
D
A
L
SA
V
D
GR
TE
H
Q
I
L
H
N
L
RQWG
Q
G
RT
V
I
IS
AHRLS
AL
T
E
A
S
EI
I
V
M
QH
G
H
I
AQ
RG
N
H
DV
L
A
QQS
G
W
Y
R
D
MY
R
Y
Q
QL
EAA
L
DDAPE
N
R
E
E
fig|83333.1.peg.445
Escherichia coli K12 (1-586/590)
MR
L
F
A
QL
S
W
Y
FRR
E
------
W
--------
R
R
YLG
A
VALL
VI
--
-
--IA
ML
Q
L
VP
P
KVVGIVV
DG
VTEQHF
T
TGQ
I
L
M
W
I
A
TM
V
L
--
--
----
-
--
IA
VVV
Y
LLR
Y
VW
R
V
L
LFG
A
SYQ
LA
VE
LR
E
D
YYRQLS
RQ
H
P
E
F
YL
R
H
R
TG
D
L
M
A
R
A
TND
V
D
-------
R
VV
FAAGEGVL
T
L
V
-
-D
S
LV
M
G
CAV
L
I
M
M
ST
QI
SWQL
---
T
L
F
S
L
L
P
M
PV
M
AI
MIKRNG
D
ALHE
RF
K
LAQ
A
AFS
S
L
ND
RTQE
S
LTS
I
--
-
-RM
I
KA
FG
-----------
LED
R
QSALFAADAEDTGKKN
M
R
VA
R
I
D
A
-
RF
DP
T
I
Y
I
AI
GM
A
N
--
LL
A
I
G
G
G
S
WMV
V
Q
GSLT
L
G
Q
LT
S
F
M
M
YLG
L
M
IW
P
M
LA
L
A
WM
FNIVERG
S
A
AY
S
R
IR
A
M
LAEA
P
V
V
N
DG
S
E
PV
PE
----
----
-
--G
RG
E
L
DV
N
IH
--
Q
FTYP
QT
D
H
PAL
E
N
V
N
F
A
L
K
P
G
QM
LGIC
G
P
TGSGKSTL
L
SLI
Q
R
H
F
D
V
S
EG
D
IR
F
HD
I
PL
TK
L
Q
L
D
S
W
R
SR
L
A
V
VSQ
T
P
F
LF
S
DTVANNIALG
-
CPNA
T
Q
Q
E
IE
H
V
AR
L
A
SVH
D
D
I
LR
L
PQ
G
Y
DT
E
V
GE
R
GV
M
LSGGQKQRI
S
IARALL
VNAE
ILILD
D
A
L
SA
V
D
GR
TE
H
Q
I
L
H
N
L
RQWG
Q
G
RT
V
I
IS
AHRLS
AL
T
E
A
S
EI
I
V
M
QH
G
H
I
AQ
RG
N
H
DV
L
A
QQS
G
W
Y
R
D
MY
R
Y
Q
QL
EAA
L
DDAPE
N
R
E
E
fig|749538.3.peg.1389
Escherichia coli MS 116-1 (1-586/590)
MR
L
F
A
QL
S
W
Y
FRR
E
------
W
--------
R
R
YLG
A
VALL
VI
--
-
--IA
ML
Q
L
VP
P
KVVGIVV
DG
VTEQHF
T
TGQ
I
L
M
W
I
A
TM
V
L
--
--
----
-
--
IA
VVV
Y
LLR
Y
VW
R
V
L
LFG
A
SYQ
LA
VE
LR
E
D
YYRQLS
RQ
H
P
E
F
YL
R
H
R
TG
D
L
M
A
R
A
TND
V
D
-------
R
VV
FAAGEGVL
T
L
V
-
-D
S
LV
M
G
CAV
L
I
M
M
ST
QI
SWQL
---
T
L
F
S
L
L
P
M
PV
M
AI
MIKRNG
D
ALHE
RF
K
LAQ
A
AFS
S
L
ND
RTQE
S
LTS
I
--
-
-RM
I
KA
FG
-----------
LED
R
QSALFAADAEDTGKKN
M
R
VA
R
I
D
A
-
RF
DP
T
I
Y
I
AI
GM
A
N
--
LL
A
I
G
G
G
S
WMV
V
Q
GSLT
L
G
Q
LT
S
F
M
M
YLG
L
M
IW
P
M
LA
L
A
WM
FNIVERG
S
A
AY
S
R
IR
A
M
LAEA
P
V
V
N
DG
S
E
PV
PE
----
----
-
--G
RG
E
L
DV
N
IH
--
Q
FTYP
QT
D
H
PAL
E
N
V
N
F
A
L
K
P
G
QM
LGIC
G
P
TGSGKSTL
L
SLI
Q
R
H
F
D
V
S
EG
D
IR
F
HD
I
PL
TK
L
Q
L
D
S
W
R
SR
L
A
V
VSQ
T
P
F
LF
S
DTVANNIALG
-
CPNA
T
Q
Q
E
IE
H
V
AR
L
A
SVH
D
D
I
LR
L
PQ
G
Y
DT
E
V
GE
R
GV
M
LSGGQKQRI
S
IARALL
VNAE
ILILD
D
A
L
SA
V
D
GR
TE
H
Q
I
L
H
N
L
RQWG
Q
G
RT
V
I
IS
AHRLS
AL
T
E
A
S
EI
I
V
M
QH
G
H
I
AQ
RG
N
H
DV
L
A
QQS
G
W
Y
R
D
MY
R
Y
Q
QL
EAA
L
DDAPE
N
R
E
E
fig|749540.3.peg.3766
Escherichia coli MS 146-1 (1-586/590)
MR
L
F
A
QL
S
W
Y
FRR
E
------
W
--------
R
R
YLG
A
VALL
VI
--
-
--IA
ML
Q
L
VP
P
KVVGIVV
DG
VTEQHF
T
TGQ
I
L
M
W
I
A
TM
V
L
--
--
----
-
--
IA
VVV
Y
LLR
Y
VW
R
V
L
LFG
A
SYQ
LA
VE
LR
E
D
YYRQLS
RQ
H
P
E
F
YL
R
H
R
TG
D
L
M
A
R
A
TND
V
D
-------
R
VV
FAAGEGVL
T
L
V
-
-D
S
LV
M
G
CAV
L
I
M
M
ST
QI
SWQL
---
T
L
F
S
L
L
P
M
PV
M
AI
MIKRNG
D
ALHE
RF
K
LAQ
A
AFS
S
L
ND
RTQE
S
LTS
I
--
-
-RM
I
KA
FG
-----------
LED
R
QSALFAADAEDTGKKN
M
R
VA
R
I
D
A
-
RF
DP
T
I
Y
I
AI
GM
A
N
--
LL
A
I
G
G
G
S
WMV
V
Q
GSLT
L
G
Q
LT
S
F
M
M
YLG
L
M
IW
P
M
LA
L
A
WM
FNIVERG
S
A
AY
S
R
IR
A
M
LAEA
P
V
V
N
DG
S
E
PV
PE
----
----
-
--G
RG
E
L
DV
N
IH
--
Q
FTYP
QT
D
H
PAL
E
N
V
N
F
A
L
K
P
G
QM
LGIC
G
P
TGSGKSTL
L
SLI
Q
R
H
F
D
V
S
EG
D
IR
F
HD
I
PL
TK
L
Q
L
D
S
W
R
SR
L
A
V
VSQ
T
P
F
LF
S
DTVANNIALG
-
CPNA
T
Q
Q
E
IE
H
V
AR
L
A
SVH
D
D
I
LR
L
PQ
G
Y
DT
E
V
GE
R
GV
M
LSGGQKQRI
S
IARALL
VNAE
ILILD
D
A
L
SA
V
D
GR
TE
H
Q
I
L
H
N
L
RQWG
Q
G
RT
V
I
IS
AHRLS
AL
T
E
A
S
EI
I
V
M
QH
G
H
I
AQ
RG
N
H
DV
L
A
QQS
G
W
Y
R
D
MY
R
Y
Q
QL
EAA
L
DDAPE
N
R
E
E
fig|316407.3.peg.434
Escherichia coli W3110 (1-586/590)
MR
L
F
A
QL
S
W
Y
FRR
E
------
W
--------
R
R
YLG
A
VALL
VI
--
-
--IA
ML
Q
L
VP
P
KVVGIVV
DG
VTEQHF
T
TGQ
I
L
M
W
I
A
TM
V
L
--
--
----
-
--
IA
VVV
Y
LLR
Y
VW
R
V
L
LFG
A
SYQ
LA
VE
LR
E
D
YYRQLS
RQ
H
P
E
F
YL
R
H
R
TG
D
L
M
A
R
A
TND
V
D
-------
R
VV
FAAGEGVL
T
L
V
-
-D
S
LV
M
G
CAV
L
I
M
M
ST
QI
SWQL
---
T
L
F
S
L
L
P
M
PV
M
AI
MIKRNG
D
ALHE
RF
K
LAQ
A
AFS
S
L
ND
RTQE
S
LTS
I
--
-
-RM
I
KA
FG
-----------
LED
R
QSALFAADAEDTGKKN
M
R
VA
R
I
D
A
-
RF
DP
T
I
Y
I
AI
GM
A
N
--
LL
A
I
G
G
G
S
WMV
V
Q
GSLT
L
G
Q
LT
S
F
M
M
YLG
L
M
IW
P
M
LA
L
A
WM
FNIVERG
S
A
AY
S
R
IR
A
M
LAEA
P
V
V
N
DG
S
E
PV
PE
----
----
-
--G
RG
E
L
DV
N
IH
--
Q
FTYP
QT
D
H
PAL
E
N
V
N
F
A
L
K
P
G
QM
LGIC
G
P
TGSGKSTL
L
SLI
Q
R
H
F
D
V
S
EG
D
IR
F
HD
I
PL
TK
L
Q
L
D
S
W
R
SR
L
A
V
VSQ
T
P
F
LF
S
DTVANNIALG
-
CPNA
T
Q
Q
E
IE
H
V
AR
L
A
SVH
D
D
I
LR
L
PQ
G
Y
DT
E
V
GE
R
GV
M
LSGGQKQRI
S
IARALL
VNAE
ILILD
D
A
L
SA
V
D
GR
TE
H
Q
I
L
H
N
L
RQWG
Q
G
RT
V
I
IS
AHRLS
AL
T
E
A
S
EI
I
V
M
QH
G
H
I
AQ
RG
N
H
DV
L
A
QQS
G
W
Y
R
D
MY
R
Y
Q
QL
EAA
L
DDAPE
N
R
E
E
fig|316385.7.peg.409
Escherichia coli str. K-12 substr. DH10B (1-586/590)
MR
L
F
A
QL
S
W
Y
FRR
E
------
W
--------
R
R
YLG
A
VALL
VI
--
-
--IA
ML
Q
L
VP
P
KVVGIVV
DG
VTEQHF
T
TGQ
I
L
M
W
I
A
TM
V
L
--
--
----
-
--
IA
VVV
Y
LLR
Y
VW
R
V
L
LFG
A
SYQ
LA
VE
LR
E
D
YYRQLS
RQ
H
P
E
F
YL
R
H
R
TG
D
L
M
A
R
A
TND
V
D
-------
R
VV
FAAGEGVL
T
L
V
-
-D
S
LV
M
G
CAV
L
I
M
M
ST
QI
SWQL
---
T
L
F
S
L
L
P
M
PV
M
AI
MIKRNG
D
ALHE
RF
K
LAQ
A
AFS
S
L
ND
RTQE
S
LTS
I
--
-
-RM
I
KA
FG
-----------
LED
R
QSALFAADAEDTGKKN
M
R
VA
R
I
D
A
-
RF
DP
T
I
Y
I
AI
GM
A
N
--
LL
A
I
G
G
G
S
WMV
V
Q
GSLT
L
G
Q
LT
S
F
M
M
YLG
L
M
IW
P
M
LA
L
A
WM
FNIVERG
S
A
AY
S
R
IR
A
M
LAEA
P
V
V
N
DG
S
E
PV
PE
----
----
-
--G
RG
E
L
DV
N
IH
--
Q
FTYP
QT
D
H
PAL
E
N
V
N
F
A
L
K
P
G
QM
LGIC
G
P
TGSGKSTL
L
SLI
Q
R
H
F
D
V
S
EG
D
IR
F
HD
I
PL
TK
L
Q
L
D
S
W
R
SR
L
A
V
VSQ
T
P
F
LF
S
DTVANNIALG
-
CPNA
T
Q
Q
E
IE
H
V
AR
L
A
SVH
D
D
I
LR
L
PQ
G
Y
DT
E
V
GE
R
GV
M
LSGGQKQRI
S
IARALL
VNAE
ILILD
D
A
L
SA
V
D
GR
TE
H
Q
I
L
H
N
L
RQWG
Q
G
RT
V
I
IS
AHRLS
AL
T
E
A
S
EI
I
V
M
QH
G
H
I
AQ
RG
N
H
DV
L
A
QQS
G
W
Y
R
D
MY
R
Y
Q
QL
EAA
L
DDAPE
N
R
E
E
fig|511145.12.peg.466
Escherichia coli str. K-12 substr. MG1655 (1-586/590)
MR
L
F
A
QL
S
W
Y
FRR
E
------
W
--------
R
R
YLG
A
VALL
VI
--
-
--IA
ML
Q
L
VP
P
KVVGIVV
DG
VTEQHF
T
TGQ
I
L
M
W
I
A
TM
V
L
--
--
----
-
--
IA
VVV
Y
LLR
Y
VW
R
V
L
LFG
A
SYQ
LA
VE
LR
E
D
YYRQLS
RQ
H
P
E
F
YL
R
H
R
TG
D
L
M
A
R
A
TND
V
D
-------
R
VV
FAAGEGVL
T
L
V
-
-D
S
LV
M
G
CAV
L
I
M
M
ST
QI
SWQL
---
T
L
F
S
L
L
P
M
PV
M
AI
MIKRNG
D
ALHE
RF
K
LAQ
A
AFS
S
L
ND
RTQE
S
LTS
I
--
-
-RM
I
KA
FG
-----------
LED
R
QSALFAADAEDTGKKN
M
R
VA
R
I
D
A
-
RF
DP
T
I
Y
I
AI
GM
A
N
--
LL
A
I
G
G
G
S
WMV
V
Q
GSLT
L
G
Q
LT
S
F
M
M
YLG
L
M
IW
P
M
LA
L
A
WM
FNIVERG
S
A
AY
S
R
IR
A
M
LAEA
P
V
V
N
DG
S
E
PV
PE
----
----
-
--G
RG
E
L
DV
N
IH
--
Q
FTYP
QT
D
H
PAL
E
N
V
N
F
A
L
K
P
G
QM
LGIC
G
P
TGSGKSTL
L
SLI
Q
R
H
F
D
V
S
EG
D
IR
F
HD
I
PL
TK
L
Q
L
D
S
W
R
SR
L
A
V
VSQ
T
P
F
LF
S
DTVANNIALG
-
CPNA
T
Q
Q
E
IE
H
V
AR
L
A
SVH
D
D
I
LR
L
PQ
G
Y
DT
E
V
GE
R
GV
M
LSGGQKQRI
S
IARALL
VNAE
ILILD
D
A
L
SA
V
D
GR
TE
H
Q
I
L
H
N
L
RQWG
Q
G
RT
V
I
IS
AHRLS
AL
T
E
A
S
EI
I
V
M
QH
G
H
I
AQ
RG
N
H
DV
L
A
QQS
G
W
Y
R
D
MY
R
Y
Q
QL
EAA
L
DDAPE
N
R
E
E
fig|511145.6.peg.461
Escherichia coli str. K-12 substr. MG1655 (1-586/590)
MR
L
F
A
QL
S
W
Y
FRR
E
------
W
--------
R
R
YLG
A
VALL
VI
--
-
--IA
ML
Q
L
VP
P
KVVGIVV
DG
VTEQHF
T
TGQ
I
L
M
W
I
A
TM
V
L
--
--
----
-
--
IA
VVV
Y
LLR
Y
VW
R
V
L
LFG
A
SYQ
LA
VE
LR
E
D
YYRQLS
RQ
H
P
E
F
YL
R
H
R
TG
D
L
M
A
R
A
TND
V
D
-------
R
VV
FAAGEGVL
T
L
V
-
-D
S
LV
M
G
CAV
L
I
M
M
ST
QI
SWQL
---
T
L
F
S
L
L
P
M
PV
M
AI
MIKRNG
D
ALHE
RF
K
LAQ
A
AFS
S
L
ND
RTQE
S
LTS
I
--
-
-RM
I
KA
FG
-----------
LED
R
QSALFAADAEDTGKKN
M
R
VA
R
I
D
A
-
RF
DP
T
I
Y
I
AI
GM
A
N
--
LL
A
I
G
G
G
S
WMV
V
Q
GSLT
L
G
Q
LT
S
F
M
M
YLG
L
M
IW
P
M
LA
L
A
WM
FNIVERG
S
A
AY
S
R
IR
A
M
LAEA
P
V
V
N
DG
S
E
PV
PE
----
----
-
--G
RG
E
L
DV
N
IH
--
Q
FTYP
QT
D
H
PAL
E
N
V
N
F
A
L
K
P
G
QM
LGIC
G
P
TGSGKSTL
L
SLI
Q
R
H
F
D
V
S
EG
D
IR
F
HD
I
PL
TK
L
Q
L
D
S
W
R
SR
L
A
V
VSQ
T
P
F
LF
S
DTVANNIALG
-
CPNA
T
Q
Q
E
IE
H
V
AR
L
A
SVH
D
D
I
LR
L
PQ
G
Y
DT
E
V
GE
R
GV
M
LSGGQKQRI
S
IARALL
VNAE
ILILD
D
A
L
SA
V
D
GR
TE
H
Q
I
L
H
N
L
RQWG
Q
G
RT
V
I
IS
AHRLS
AL
T
E
A
S
EI
I
V
M
QH
G
H
I
AQ
RG
N
H
DV
L
A
QQS
G
W
Y
R
D
MY
R
Y
Q
QL
EAA
L
DDAPE
N
R
E
E
fig|749548.3.peg.2606
Escherichia coli MS 196-1 (1-586/590)
MR
L
F
A
QL
S
W
Y
FRR
E
------
W
--------
R
R
YLG
A
VALL
VI
--
-
--IA
ML
Q
L
VP
P
KVVGIVV
DG
VTEQHF
T
TGQ
I
L
M
W
I
A
TM
V
L
--
--
----
-
--
IA
VVV
Y
LLR
Y
VW
R
V
L
LFG
A
SYQ
LA
VE
LR
E
D
YYRQLS
RQ
H
P
E
F
YL
R
H
R
TG
D
L
M
A
R
A
TND
V
D
-------
R
VV
FAAGEGVL
M
L
V
-
-D
S
LV
M
G
CAV
L
I
M
M
ST
QI
SWQL
---
T
L
F
S
L
L
Q
M
PV
M
AI
MIKRNG
D
ALHE
RF
K
LAQ
A
AFS
S
L
ND
RTQE
S
LTS
I
--
-
-RM
I
KA
FG
-----------
LED
R
QSALFAADAEDTGKKN
M
R
VA
R
I
D
A
-
RF
DP
T
I
Y
I
AI
GM
A
N
--
LL
A
I
G
G
G
S
WMV
V
Q
GSLT
L
G
Q
LT
S
F
M
M
YLG
L
M
IW
P
M
LA
L
A
WM
FNIVERG
S
A
AY
S
R
IR
A
M
LAEA
P
V
V
N
DG
S
E
PV
PE
----
----
-
--G
RG
E
L
DV
N
IH
--
Q
FTYP
QT
D
H
PAL
E
N
V
N
F
A
L
K
P
G
QM
LGIC
G
P
TGSGKSTL
L
SLI
Q
R
H
F
D
V
S
EG
D
IR
F
HD
I
PL
TK
L
Q
L
D
S
W
R
SR
L
A
V
VSQ
T
P
F
LF
S
DTVANNIALG
-
CPNA
T
Q
Q
E
IE
H
V
AR
L
A
SVH
D
D
I
LR
L
PQ
G
Y
DT
E
V
GE
R
GV
M
LSGGQKQRI
S
IARALL
VNAE
ILILD
D
A
L
SA
V
D
GR
TE
H
Q
I
L
H
N
L
RQWG
Q
G
RT
V
I
IS
AHRLS
AL
T
E
A
S
EI
I
V
M
QH
G
H
I
AQ
RG
N
H
DV
L
A
QQS
G
W
Y
R
D
MY
R
Y
Q
QL
EAA
L
DDAPE
N
R
E
E
fig|550677.3.peg.2158
Escherichia coli B354 (16-571/573)
W
--------
-
M
LSL
G
I
AL
A
IV
TL
L
ASIG
L
L
T
L
--
-
-------
S
G
WFL---
S
ASA
V
A
G
VAG
LY
SFNY
ML
P
AAG
V
RG
A
A
ITR
T
AGR
Y
FE
R
L
V
SHD
A
TFR
V
L
QH
LR
I
Y
TFSKLL
PLS
P
A
GLA
R
Y
R
Q
G
E
L
LN
R
V
VA
D
V
D
TLDH
LY
L
R
V
I
SPLVGAFV
V
IM
-
--
V
V
T
I
G
---
L
S
F
L
D
F
TL
AF
T
L
GG
I
M
L
L
T
L
F
L
M
P
P
L
FY
------
R
A---
-G
K
STG
Q
NLT
H
L
R
G
QYRQ
Q
LTA
W
LQ
G
QAE
L
TI
FG
-----------
ASD
R
YRTQLENTEIQWLEAQ
R
R
QS
E
L
T
A
-
LS
QA
I
M
L
L
IG
A
LA
V
--
I
L
M
L
W
M
A
S
-GG
V
G
G
N
A
E
P
G
A
L
I
A
L
F
--
V
F
C
A
LA
AF
EA
L
A
PV
-------
T
G
AF
Q
H
LG
QV
IASA
V
R
I
T
D
L
T
D
QK
PE
VTFP
DTQT
R
VAD
R
V
S
-
-
L
T
LR
D
V
Q
FTYP
EQ
S
Q
Q
ALK
G
I
S
L
Q
V
N
A
G
EH
I
A
I
L
G
R
TG
C
GKSTL
L
Q
L
L
T
R
A
W
D
P
Q
Q
G
K
I
L
L
N
D
S
P
I
AS
L
N
E
A
T
LR
QT
ISV
V
P
Q
R
V
H
LF
S
A
T
L
R
D
N
L
L
L
A
-
SPGS
S
D
E
A
L
A
E
I
L
R
R
V
GLE
K
L
L
E-
-
DA
G
L
NS
W
LGE
G
G
R
Q
LSGG
E
L
R
R
L
AIARALL
HDAP
LVL
LDE
P
T
EG
L
D
AT
TE
S
Q
I
L
EL
L
AEMM
H
E
K
T
V
L
MV
T
HRL
RG
L
S
RFQ
QLI
V
M
DN
G
Q
I
I
E
Q
GTH
AE
LL
ARQ
G
R
Y
Y
Q
FK
Q
Consen1
Primary consensus
MRsFsQLw
tfrRl
------
W
--------
r
gvAllmm
a
ml
l
P
Dg
t
vl
wla
vvgl
----
l
----
y
Y
s
l
a
vv
lR
d
rqp
sffd
q
tG
lisR
TnD
e
-------
Vv
Tvvr
alv
g
---
l
vmmf
sWql
---
L
al
p
pvvai
r
rfr
a
d
nd
s
i
g
i
Fg
-----------
R
Mq
r
d
-
dP
i
l
slal
--
ll
l
g
S
v
gslt
G
lt
f
sylg
l
Pl
Lt
-------
A
qr
aa
f
i
Dg
r
------
r
rgt
dve
nv
FtYp
D
paLkNiNl
ip
g
valvG
tGSGKSTlaSLi
ryydl
EGeIr
dg
pL
l
l
slR
vAmVsQ
p
lfaDTvanNialg
-
seerie
aar
a
d
i
m
G
dT
lGE
Gv
LSgGQkQriaiARaLl
ILILDeAtsaiD
tE
aIqhaL
e
rT
lviAHRLSti
dAdeIvVl
G
iverGtH
Ll
G
Y
qmyq
Q
geeLaasvr
eEsLSA
Consen2
Secondary consensus
l
a
s
ylk
elaygsp
ptiapfka
l
ai
v
-
-
--
v
n
l
iv
g
p
y
--
faag
-
rgia
-
r
v
-
la
m
r
gmh
eeyl
h
v
v
a
y
dvirdlyv
a
ll
-
ssi
acavm
ast
d
rm
si
vi
i
vs
lv
d
ivk
k
mg
g
m
-
v
rgqevetkrfdk
s
s
f
r
l
i
gmincgaf
i
a
a
dtie
iy
v
msmi
m
m
a
fniverg
sq
vm
p
s
pe
y
-
sae
-
in
--
a
-
lv
v
f
k
r
lgic
s
il
l
g
fp
d
l
hd
d
y
h
aw
l
q
v
vl
fla
vtyar
t
q
vw
vle
v
e
a
l
y
n
v
r
llsl
v
v
d
las
s
q
lan
t
is
al
st
aaqq
n
a
dlh
eaa
ddape
r
e
Consensus 1
(when a gap)
Conservative difference
Consensus 2
(when a gap)
Nonconservative diff.
Other character