┌─ Escherichia coli (2-349/349) 1044A   
                                                                           ├─ Escherichia coli (2-349/349) 1212A   
                                                                           ├─ Escherichia coli (2-349/349) O157:H7   
                                                                           ├─ Escherichia coli (2-349/349) O157:H7 EDL933   
                                                                           ├─ Escherichia coli (2-349/349) O157:H7 str. EC4042   
                                                                           ├─ Escherichia coli (2-349/349) O157:H7 str. EC4076   
                                                                           ├─ Escherichia coli (2-349/349) O157:H7 str. EC4115   
                                                                           ├─ Escherichia coli (2-349/349) O157:H7 str. EC4206   
                                                                           ├─ Escherichia coli (2-349/349) O157:H7 str. EC4486   
                                                                           ├─ Escherichia coli (2-349/349) O157:H7 str. EC508   
                                                                           ├─ Escherichia coli (2-349/349) O157:H7 str. FRIK2000   
                                                                           ├─ Escherichia coli (2-349/349) O157:H7 str. Sakai   
                                                                           ├─ Escherichia coli (2-349/349) O157:H7 str. TW14588   
                                                                          ┌┼─ Escherichia coli (2-349/349) O55:H7 str. CB9615   
                                                                          │├─ Escherichia coli (2-349/349) O157:H7 str. TW14359   
                                                                          │├─ Escherichia coli (2-349/349) O157:H7 str. FRIK966   
                                                                          │├─ Escherichia coli (2-349/349) O157:H7 str. EC869   
                                                                          │├─ Escherichia coli (2-349/349) O157:H7 str. EC4501   
                                                                          │├─ Escherichia coli (2-349/349) O157:H7 str. EC4401   
                                                                          │├─ Escherichia coli (2-349/349) O157:H7 str. EC4196   
                                                                         ┌┤├─ Escherichia coli (2-349/349) O157:H7 str. EC4113   
                                                                         ││├─ Escherichia coli (2-349/349) O157:H7 str. EC4045   
                                                                         ││├─ Escherichia coli (2-349/349) O157:H7 str. EC4024   
                                                                         ││├─ Escherichia coli (2-349/349) O157:H7 EDL933   
                                                                        ┌┤│├─ Escherichia coli (2-349/349) 536A   
                                                                        │││└─ Escherichia coli (2-349/349) 1125A   
                                                                        ││└┬─ Escherichia coli (2-349/349) M718   
                                                                        ││ └─ Escherichia coli (2-349/349) B185   
                                                                       ┌┤└┬─ Escherichia coli (2-349/349) MS 84-1   
                                                                       ││ └─ Escherichia coli (2-349/349) MS 124-1   
                                                                       ││┌─ Escherichia coli (2-349/349) ATCC 8739   
                                                                       ││├─ Escherichia coli (2-349/349) HS   
                                                                       │└┼─ Escherichia coli (2-349/349) HS   
                                                                       │ ├─ Escherichia coli (2-349/349) ATCC 8739   
                                                                       │ └─ Escherichia coli (2-349/349) 1827-70   
                                                                      ┌┤ ┌─ Escherichia coli (2-349/349) 101-1   
                                                                      ││ ├─ Escherichia coli (2-349/349) BL21   
                                                                      ││┌┼─ Escherichia coli (2-349/349) MS 187-1   
                                                                      │││├─ Escherichia coli (DE3 2-349/349) BL21(DE3)   
                                                                      │││└─ Escherichia coli (2-349/349) B str. REL606   
                                                                      │││┌─ Escherichia coli (2-349/349) E110019   
                                                                      │└┤├─ Escherichia coli (2-349/349) E24377A   
                                                                      │ │├─ Escherichia coli (2-349/349) H591   
                                                                      │ │├─ Escherichia coli (2-349/349) O111:H- str. 11128   
                                                                      │ │├─ Escherichia coli (2-349/349) SE11   
                                                                      │ └┼─ Escherichia coli (2-349/349) TA271   
                                                                      │  ├─ Escherichia coli (2-349/349) O26:H11 str. 11368   
                                                                      │  ├─ Escherichia coli (2-349/349) MS 119-7   
                                                                     ┌┤  ├─ Escherichia coli (2-349/349) EC4100B   
                                                                     ││  ├─ Escherichia coli (2-349/349) E24377A   
                                                                     ││  └─ Escherichia coli (2-349/349) E110019   
                                                                     ││ ┌─ Escherichia coli (2-349/349) MS 107-1   
                                                                     ││ ├─ Escherichia coli (2-349/349) MS 78-1   
                                                                     ││┌┼─ Escherichia coli (2-349/349) SMS-3-5   
                                                                     │││└─ Escherichia coli (2-349/349) MS 182-1   
                                                                     │││    ┌─ Escherichia coli (2-349/349) 042   
                                                                     │││    ├─ Escherichia coli (2-349/349) H299   
                                                                     │││   ┌┼─ Escherichia coli (2-349/349) MS 69-1   
                                                                     │││   │└─ Escherichia coli (2-349/349) 042   
                                                                     │││  ┌┤┌─ Escherichia coli (2-349/349) ETEC H10407   
                                                                     │└┤  │└┼─ Escherichia coli (2-349/349) TA143   
                                                                     │ │ ┌┤ └─ Escherichia coli (2-349/349) B354   
                                                                     │ │ │└─ Escherichia coli (6-349/349) TA280   
                                                                     │ │┌┤┌─ Escherichia coli (2-349/349) FVEC1412   
                                                                     │ ││└┼─ Escherichia coli (2-349/349) UMN026   
                                                                     │ ││ ├─ Escherichia coli (2-349/349) MS 198-1   
                                                                     │ ││ └─ Escherichia coli (2-349/349) FVEC1302   
                                                                     │ ││┌─ Escherichia coli (2-349/349) MS 21-1   
                                                                     │ └┤│┌─ Escherichia coli (2-349/349) 536   
                                                                     │  ││├─ Escherichia coli (2-349/349) 83972   
                                                                     │  ││├─ Escherichia coli (2-349/349) APEC O1   
                                                                     │  ││├─ Escherichia coli (2-349/349) CFT073   
                                                                     │  ││├─ Escherichia coli (2-349/349) E2348/69   
                                                                     │  ││├─ Escherichia coli (2-349/349) ED1a   
                                                                    ┌┤  └┤├─ Escherichia coli (2-349/349) F11   
                                                                    ││   │├─ Escherichia coli (2-349/349) M605   
                                                                    ││   │├─ Escherichia coli (2-349/349) MS 200-1   
                                                                    ││   │├─ Escherichia coli (2-349/349) NC101   
                                                                    ││   │├─ Escherichia coli (2-349/349) O83:H1 str. NRG 857C   
                                                                    ││   │├─ Escherichia coli (2-349/349) SE15   
                                                                    ││   │├─ Escherichia coli (2-349/349) UM146   
                                                                    ││   │├─ Escherichia coli (2-349/349) UTI89   
                                                                    ││   └┼─ Escherichia coli (2-349/349) WV_060327   
                                                                    ││    ├─ Escherichia coli (2-349/349) UTI89   
                                                                    ││    ├─ Escherichia coli (2-349/349) TA206   
                                                                    ││    ├─ Escherichia coli (2-349/349) S88   
                                                                    ││    ├─ Escherichia coli (2-349/349) O127:H6 str. E2348/69   
                                                                    ││    ├─ Escherichia coli (2-349/349) MS 45-1   
                                                                    ││    ├─ Escherichia coli (2-349/349) MS 185-1   
                                                                    ││    ├─ Escherichia coli (2-349/349) IHE3034   
                                                                   ┌┤│    ├─ Escherichia coli (2-349/349) F11   
                                                                   │││    ├─ Escherichia coli (2-349/349) ED1a   
                                                                   │││    ├─ Escherichia coli (2-349/349) CFT073   
                                                                   │││    ├─ Escherichia coli (2-349/349) APEC O1   
                                                                   │││    ├─ Escherichia coli (2-349/349) ABU 83972   
                                                                   │││    ├─ Escherichia coli (2-349/349) 536   
                                                                   │││    └─ Escherichia coli (2-349/349) 2362-75   
                                                                   │││┌─ fig|6666666.5357.peg.1693 TY-2482 (2-349/349) strain   
                                                                   │││├─ Escherichia coli (2-349/349) 55989   
                                                                   │││├─ Escherichia coli (2-349/349) KO11   
                                                                  ┌┤│└┼─ Escherichia coli (2-349/349) W   
                                                                  │││ ├─ Escherichia coli (2-349/349) W   
                                                                  │││ ├─ Escherichia coli (2-349/349) B088   
                                                                  │││ ├─ Escherichia coli (2-349/349) 55989   
                                                                  │││ └─ fig|1040638.4.peg.5222 O104:H4 (2-349/349) str. LB226692   
                                                                  ││└┬─ Escherichia coli (2-349/349) IAI1   
                                                                  ││ └─ Escherichia coli (2-349/349) IAI1   
                                                                  ││┌─ Escherichia coli (2-349/349) B171   
                                                                  ││├─ Escherichia coli (2-349/349) B7A   
                                                                  ││├─ Escherichia coli (2-349/349) E22   
┌─────────────────────────────────────────────────────────────────┤└┼─ Escherichia coli (2-349/349) O103:H2 str. 12009   
│                                                                 │ ├─ Escherichia coli (2-349/349) MS 145-7   
│                                                                 │ ├─ Escherichia coli (2-349/349) E22   
│                                                                 │ ├─ Escherichia coli (2-349/349) B7A   
│                                                                 │ └─ Escherichia coli (2-349/349) B171   
│                                                                 │┌─ Escherichia coli (2-349/349) MS 115-1   
│                                                                 ││┌─ Escherichia coli (2-349/349) 53638   
│                                                                 ││├─ Escherichia coli (2-349/349) DH1   
│                                                                 ││├─ Escherichia coli (2-349/349) K12   
│                                                                 └┤├─ Escherichia coli (2-349/349) MS 146-1   
│                                                                  │├─ Escherichia coli (2-349/349) MS 196-1   
│                                                                  │├─ Escherichia coli (2-349/349) str. K-12 substr. DH10B   
│                                                                  │├─ Escherichia coli (2-349/349) str. K-12 substr. MG1655   
│                                                                  └┼─ Escherichia coli (2-349/349) str. K-12 substr. MG1655   
┤                                                                   ├─ Escherichia coli (2-349/349) str. K-12 substr. DH10B   
│                                                                   ├─ Escherichia coli (2-349/349) W3110   
│                                                                   ├─ Escherichia coli (2-349/349) MS 175-1   
│                                                                   ├─ Escherichia coli (2-349/349) MS 116-1   
│                                                                   ├─ Escherichia coli (2-349/349) H736   
│                                                                   ├─ Escherichia coli (2-349/349) BW2952   
│                                                                   └─ Escherichia coli (2-349/349) 53638   
│                                                                 ┌─ Escherichia coli MS 78-1   
│                                                                 │┌─ Escherichia coli MS 182-1   
│                                                                 ││ ┌─ Escherichia coli E110019   
│                                                                 ││┌┴─ Escherichia coli E110019   
│                                                                 │││    ┌─ Escherichia coli 101-1   
│                                                                 │││    ├─ Escherichia coli 53638   
│                                                                 │││    ├─ Escherichia coli ATCC 8739   
└─────────────────────────────────────────────────────────────────┤││    ├─ Escherichia coli B str. REL606   
                                                                  │││    ├─ Escherichia coli BW2952   
                                                                  │││    ├─ Escherichia coli EC4100B   
                                                                  │││    ├─ Escherichia coli HS   
                                                                  │││    ├─ Escherichia coli K12   
                                                                  │││    ├─ Escherichia coli MS 116-1   
                                                                  │││    ├─ Escherichia coli MS 146-1   
                                                                  └┤│    ├─ Escherichia coli MS 187-1   
                                                                   ││    ├─ Escherichia coli SE11   
                                                                   ││    ├─ Escherichia coli str. K-12 substr. DH10B   
                                                                   ││    ├─ Escherichia coli str. K-12 substr. MG1655   
                                                                   ││   ┌┼─ Escherichia coli str. K-12 substr. MG1655   
                                                                   ││   │├─ Escherichia coli str. K-12 substr. DH10B   
                                                                   ││   │├─ Escherichia coli W3110   
                                                                   ││   │├─ Escherichia coli MS 84-1   
                                                                   ││   │├─ Escherichia coli MS 175-1   
                                                                   ││   │├─ Escherichia coli MS 124-1   
                                                                   ││   │├─ Escherichia coli MS 115-1   
                                                                   ││  ┌┤├─ Escherichia coli HS   
                                                                   ││  ││├─ Escherichia coli ETEC H10407   
                                                                   └┤  ││├─ Escherichia coli DH1   
                                                                    │  ││├─ Escherichia coli (DE3) BL21(DE3)   
                                                                    │  ││├─ Escherichia coli ATCC 8739   
                                                                    │  ││├─ Escherichia coli 53638   
                                                                    │ ┌┤│└─ Escherichia coli 1827-70   
                                                                    │ ││└┬─ Escherichia coli MS 196-1   
                                                                    │ ││ └─ Escherichia coli (1-360/399) BL21   
                                                                    │ ││ ┌─ Escherichia coli IAI1   
                                                                    │ ││┌┴─ Escherichia coli IAI1   
                                                                    │ │└┤┌─ Escherichia coli MS 107-1   
                                                                    │ │ └┤ ┌─ Escherichia coli B7A   
                                                                    │┌┤  │┌┴─ Escherichia coli B7A   
                                                                    │││  └┤┌─ Escherichia coli E24377A   
                                                                    │││   │├─ Escherichia coli O111:H- str. 11128   
                                                                    │││   └┼─ Escherichia coli O26:H11 str. 11368   
                                                                    │││    ├─ Escherichia coli MS 145-7   
                                                                    │││    └─ Escherichia coli E24377A   
                                                                    │││┌─ Escherichia coli KO11   
                                                                    ││└┼─ Escherichia coli W   
                                                                    ││ ├─ Escherichia coli W   
                                                                    ││ └─ Escherichia coli B088   
                                                                    ││   ┌─ Escherichia coli FVEC1302   
                                                                    ││  ┌┼─ Escherichia coli UMN026   
                                                                    ││ ┌┤└─ Escherichia coli FVEC1412   
                                                                    ││┌┤└─ Escherichia coli MS 198-1   
                                                                    └┤│└┬─ Escherichia coli 042   
                                                                     ││ └─ Escherichia coli 042   
                                                                     ││          ┌─ Escherichia coli 83972   
                                                                     ││          ├─ Escherichia coli CFT073   
                                                                     ││          ├─ Escherichia coli MS 185-1   
                                                                     ││         ┌┼─ Escherichia coli MS 45-1   
                                                                     ││         │├─ Escherichia coli CFT073   
                                                                     ││        ┌┤└─ Escherichia coli ABU 83972   
                                                                     ││        │└─ Escherichia coli H299   
                                                                     ││       ┌┤┌─ Escherichia coli UTI89   
                                                                     ││       │└┼─ Escherichia coli UTI89   
                                                                     ││       │ └─ Escherichia coli UM146   
                                                                     ││      ┌┤┌─ Escherichia coli APEC O1   
                                                                     ││      ││├─ Escherichia coli S88   
                                                                     ││      │└┼─ Escherichia coli WV_060327   
                                                                     └┤     ┌┤ ├─ Escherichia coli IHE3034   
                                                                      │     ││ └─ Escherichia coli APEC O1   
                                                                      │    ┌┤└─ Escherichia coli O83:H1 str. NRG 857C   
                                                                      │    ││┌─ Escherichia coli E2348/69   
                                                                      │    │└┼─ Escherichia coli O127:H6 str. E2348/69   
                                                                      │   ┌┤ └─ Escherichia coli 2362-75   
                                                                      │   ││┌─ Escherichia coli 536   
                                                                      │  ┌┤└┼─ Escherichia coli MS 200-1   
                                                                      │  ││ └─ Escherichia coli 536   
                                                                      │ ┌┤└┬─ Escherichia coli SE15   
                                                                      │ ││ └─ Escherichia coli M605   
                                                                      │┌┤└─ Escherichia coli SMS-3-5   
                                                                      ││└─ Escherichia coli B354   
                                                                      ││ ┌─ Escherichia coli B185   
                                                                      ││┌┴─ Escherichia coli TA206   
                                                                      │││   ┌─ fig|1040638.4.peg.4910 O104:H4 str. LB226692   
                                                                      └┤│   ├─ Escherichia coli B171   
                                                                       ││   ├─ Escherichia coli E22   
                                                                       ││   ├─ Escherichia coli H591   
                                                                       ││   ├─ Escherichia coli O103:H2 str. 12009   
                                                                       ││  ┌┼─ Escherichia coli TA271   
                                                                       ││  │├─ Escherichia coli MS 119-7   
                                                                       └┤  │├─ Escherichia coli E22   
                                                                        │ ┌┤├─ Escherichia coli B171   
                                                                        │ ││└─ fig|6666666.5357.peg.4928 TY-2482 strain   
                                                                        │ │└┬─ Escherichia coli 55989   
                                                                        │┌┤ └─ Escherichia coli 55989   
                                                                        │││┌─ Escherichia coli ED1a   
                                                                        ││└┼─ Escherichia coli NC101   
                                                                        ││ └─ Escherichia coli ED1a   
                                                                        └┤  ┌─ Escherichia coli IAI39   
                                                                         │ ┌┴─ Escherichia coli IAI39   
                                                                         │┌┴─ Escherichia coli MS 21-1   
                                                                         ││ ┌─ Escherichia coli TA280   
                                                                         ││┌┴─ Escherichia coli MS 69-1   
                                                                         └┤│ ┌─ Escherichia coli O157:H7 EDL933   
                                                                          ││┌┴─ Escherichia coli O157:H7 EDL933   
                                                                          │││┌─ Escherichia coli 1125A   
                                                                          └┤│├─ Escherichia coli 536A   
                                                                           ││├─ Escherichia coli O157:H7   
                                                                           ││├─ Escherichia coli O157:H7 str. EC4042   
                                                                           ││├─ Escherichia coli O157:H7 str. EC4076   
                                                                           └┤├─ Escherichia coli O157:H7 str. EC4115   
                                                                            │├─ Escherichia coli O157:H7 str. EC4206   
                                                                            │├─ Escherichia coli O157:H7 str. EC4486   
                                                                            │├─ Escherichia coli O157:H7 str. EC508   
                                                                            │├─ Escherichia coli O157:H7 str. FRIK2000   
                                                                            │├─ Escherichia coli O157:H7 str. Sakai   
                                                                            │├─ Escherichia coli O157:H7 str. TW14588   
                                                                            └┼─ Escherichia coli O55:H7 str. CB9615   
                                                                             ├─ Escherichia coli O157:H7 str. TW14359   
                                                                             ├─ Escherichia coli O157:H7 str. FRIK966   
                                                                             ├─ Escherichia coli O157:H7 str. EC869   
                                                                             ├─ Escherichia coli O157:H7 str. EC4501   
                                                                             ├─ Escherichia coli O157:H7 str. EC4401   
                                                                             ├─ Escherichia coli O157:H7 str. EC4196   
                                                                             ├─ Escherichia coli O157:H7 str. EC4113   
                                                                             ├─ Escherichia coli O157:H7 str. EC4045   
                                                                             ├─ Escherichia coli O157:H7 str. EC4024   
                                                                             ├─ Escherichia coli M718   
                                                                             ├─ Escherichia coli 1212A   
                                                                             └─ Escherichia coli 1044A   
  
Ureidoglycolate dehydrogenase (EC 1.1.1.154) (129)
Malate dehydrogenase (EC 1.1.1.37) (119)
Hypothetical oxidoreductase, YbiC homolog (8)
Others (4)