fig|1040638.4.peg.4900
Escherichia coli O104:H4 str. LB226692
MFHRL
WT
L
I
RKEL
Q
SLLR
E
P
QTRAILILPV
L
I
Q
V
I
L
F
P
F
AA
T
L
---------
E
V
T
NA
T
IAI
Y
D
E
D
N
GEH
S
VEL
T
QR
F
A
R
ASA
F
THV
L
L
L
K
S
P
Q
E
I
R
PT
I
D
TQ
KA
L
L
LV
R
F
P
AD
F
S
R
KL
D
TFQ
T
A
P
L
Q
L
-
-
I
L
DG
RNS
N
S
A
Q
I
AA
N
Y
L
Q
Q
I
VKNYQ
Q
ELLE
G
KPK
P
N
NSE
L
V
V
--
--
R
N
W
YNPNLD
YK
WF
V
VP
S
L
IA
M
I
--
T
T
I
GVM
I
V
T
S
LSV
A
RERE
Q
GT
L
DQ
LLV
S
P
L
T
TW
Q
I
F
I
GK
-
---
A
V
P
A
L
I
V
AT
F
QAT
I
V
LAIGIW
A
Y
QI
P
FA
GS
LA
LF
Y
F
TMV
I
Y
GLSL
V
G
F
GLLIS
S
LCS
T
Q
Q
QA
FI
GV
F
V
F
-
M
M
PA
IL
LSG
YVS
PVE
N
MP
---
V
W
L
Q
N
LTWIN
P
I
R
HF
TD
I
T
K
Q
I
YL
K
D
A
S
L
D
IVW
NS
L
W
PLL
V
I
TATTGSA
AY
AM
FR
RKV
M
fig|6666666.5357.peg.919
Escherichia coli TY-2482
MFHRL
WT
L
I
RKEL
Q
SLLR
E
P
QTRAILILPV
L
I
Q
V
I
L
F
P
F
AA
T
L
---------
E
V
T
NA
T
IAI
Y
D
E
D
N
GEH
S
VEL
T
QR
F
A
R
ASA
F
THV
L
L
L
K
S
P
Q
E
I
R
PT
I
D
TQ
KA
L
L
LV
R
F
P
AD
F
S
R
KL
D
TFQ
T
A
P
L
Q
L
-
-
I
L
DG
RNS
N
S
A
Q
I
AA
N
Y
L
Q
Q
I
VKNYQ
Q
ELLE
G
KPK
P
N
NSE
L
V
V
--
--
R
N
W
YNPNLD
YK
WF
V
VP
S
L
IA
M
I
--
T
T
I
GVM
I
V
T
S
LSV
A
RERE
Q
GT
L
DQ
LLV
S
P
L
T
TW
Q
I
F
I
GK
-
---
A
V
P
A
L
I
V
AT
F
QAT
I
V
LAIGIW
A
Y
QI
P
FA
GS
LA
LF
Y
F
TMV
I
Y
GLSL
V
G
F
GLLIS
S
LCS
T
Q
Q
QA
FI
GV
F
V
F
-
M
M
PA
IL
LSG
YVS
PVE
N
MP
---
V
W
L
Q
N
LTWIN
P
I
R
HF
TD
I
T
K
Q
I
YL
K
D
A
S
L
D
IVW
NS
L
W
PLL
V
I
TATTGSA
AY
AM
FR
RKV
M
fig|216592.1.peg.3316
Escherichia coli 042
MFHRL
WT
L
I
RKEL
Q
SLLR
E
P
QTRAILILPV
L
I
Q
V
I
L
F
P
F
AA
T
L
---------
E
V
T
NA
T
IAI
Y
D
E
D
N
GEH
S
VEL
T
QR
F
A
R
ASA
F
THV
L
L
L
K
S
P
Q
E
I
R
PT
I
D
TQ
KA
L
L
LV
R
F
P
AD
F
S
R
KL
D
TFQ
T
A
P
L
Q
L
-
-
I
L
DG
RNS
N
S
A
Q
I
AA
N
Y
L
Q
Q
I
VKNYQ
Q
ELLE
G
KPK
P
N
NSE
L
V
V
--
--
R
N
W
YNPNLD
YK
WF
V
VP
S
L
IA
M
I
--
T
T
I
GVM
I
V
T
S
LSV
A
RERE
Q
GT
L
DQ
LLV
S
P
L
T
TW
Q
I
F
I
GK
-
---
A
V
P
A
L
I
V
AT
F
QAT
I
V
LAIGIW
A
Y
QI
P
FA
GS
LA
LF
Y
F
TMV
I
Y
GLSL
V
G
F
GLLIS
S
LCS
T
Q
Q
QA
FI
GV
F
V
F
-
M
M
PA
IL
LSG
YVS
PVE
N
MP
---
V
W
L
Q
N
LTWIN
P
I
R
HF
TD
I
T
K
Q
I
YL
K
D
A
S
L
D
IVW
NS
L
W
PLL
V
I
TATTGSA
AY
AM
FR
RKV
M
fig|216592.3.peg.908
Escherichia coli 042
MFHRL
WT
L
I
RKEL
Q
SLLR
E
P
QTRAILILPV
L
I
Q
V
I
L
F
P
F
AA
T
L
---------
E
V
T
NA
T
IAI
Y
D
E
D
N
GEH
S
VEL
T
QR
F
A
R
ASA
F
THV
L
L
L
K
S
P
Q
E
I
R
PT
I
D
TQ
KA
L
L
LV
R
F
P
AD
F
S
R
KL
D
TFQ
T
A
P
L
Q
L
-
-
I
L
DG
RNS
N
S
A
Q
I
AA
N
Y
L
Q
Q
I
VKNYQ
Q
ELLE
G
KPK
P
N
NSE
L
V
V
--
--
R
N
W
YNPNLD
YK
WF
V
VP
S
L
IA
M
I
--
T
T
I
GVM
I
V
T
S
LSV
A
RERE
Q
GT
L
DQ
LLV
S
P
L
T
TW
Q
I
F
I
GK
-
---
A
V
P
A
L
I
V
AT
F
QAT
I
V
LAIGIW
A
Y
QI
P
FA
GS
LA
LF
Y
F
TMV
I
Y
GLSL
V
G
F
GLLIS
S
LCS
T
Q
Q
QA
FI
GV
F
V
F
-
M
M
PA
IL
LSG
YVS
PVE
N
MP
---
V
W
L
Q
N
LTWIN
P
I
R
HF
TD
I
T
K
Q
I
YL
K
D
A
S
L
D
IVW
NS
L
W
PLL
V
I
TATTGSA
AY
AM
FR
RKV
M
fig|358709.5.peg.3069
Escherichia coli 101-1
MFHRL
WT
L
I
RKEL
Q
SLLR
E
P
QTRAILILPV
L
I
Q
V
I
L
F
P
F
AA
T
L
---------
E
V
T
NA
T
IAI
Y
D
E
D
N
GEH
S
VEL
T
QR
F
A
R
ASA
F
THV
L
L
L
K
S
P
Q
E
I
R
PT
I
D
TQ
KA
L
L
LV
R
F
P
AD
F
S
R
KL
D
TFQ
T
A
P
L
Q
L
-
-
I
L
DG
RNS
N
S
A
Q
I
AA
N
Y
L
Q
Q
I
VKNYQ
Q
ELLE
G
KPK
P
N
NSE
L
V
V
--
--
R
N
W
YNPNLD
YK
WF
V
VP
S
L
IA
M
I
--
T
T
I
GVM
I
V
T
S
LSV
A
RERE
Q
GT
L
DQ
LLV
S
P
L
T
TW
Q
I
F
I
GK
-
---
A
V
P
A
L
I
V
AT
F
QAT
I
V
LAIGIW
A
Y
QI
P
FA
GS
LA
LF
Y
F
TMV
I
Y
GLSL
V
G
F
GLLIS
S
LCS
T
Q
Q
QA
FI
GV
F
V
F
-
M
M
PA
IL
LSG
YVS
PVE
N
MP
---
V
W
L
Q
N
LTWIN
P
I
R
HF
TD
I
T
K
Q
I
YL
K
D
A
S
L
D
IVW
NS
L
W
PLL
V
I
TATTGSA
AY
AM
FR
RKV
M
fig|562.371.peg.2262
Escherichia coli 1044A
MFHRL
WT
L
I
RKEL
Q
SLLR
E
P
QTRAILILPV
L
I
Q
V
I
L
F
P
F
AA
T
L
---------
E
V
T
NA
T
IAI
Y
D
E
D
N
GEH
S
VEL
T
QR
F
A
R
ASA
F
THV
L
L
L
K
S
P
Q
E
I
R
PT
I
D
TQ
KA
L
L
LV
R
F
P
AD
F
S
R
KL
D
TFQ
T
A
P
L
Q
L
-
-
I
L
DG
RNS
N
S
A
Q
I
AA
N
Y
L
Q
Q
I
VKNYQ
Q
ELLE
G
KPK
P
N
NSE
L
V
V
--
--
R
N
W
YNPNLD
YK
WF
V
VP
S
L
IA
M
I
--
T
T
I
GVM
I
V
T
S
LSV
A
RERE
Q
GT
L
DQ
LLV
S
P
L
T
TW
Q
I
F
I
GK
-
---
A
V
P
A
L
I
V
AT
F
QAT
I
V
LAIGIW
A
Y
QI
P
FA
GS
LA
LF
Y
F
TMV
I
Y
GLSL
V
G
F
GLLIS
S
LCS
T
Q
Q
QA
FI
GV
F
V
F
-
M
M
PA
IL
LSG
YVS
PVE
N
MP
---
V
W
L
Q
N
LTWIN
P
I
R
HF
TD
I
T
K
Q
I
YL
K
D
A
S
L
D
IVW
NS
L
W
PLL
V
I
TATTGSA
AY
AM
FR
RKV
M
fig|562.373.peg.1245
Escherichia coli 1125A
MFHRL
WT
L
I
RKEL
Q
SLLR
E
P
QTRAILILPV
L
I
Q
V
I
L
F
P
F
AA
T
L
---------
E
V
T
NA
T
IAI
Y
D
E
D
N
GEH
S
VEL
T
QR
F
A
R
ASA
F
THV
L
L
L
K
S
P
Q
E
I
R
PT
I
D
TQ
KA
L
L
LV
R
F
P
AD
F
S
R
KL
D
TFQ
T
A
P
L
Q
L
-
-
I
L
DG
RNS
N
S
A
Q
I
AA
N
Y
L
Q
Q
I
VKNYQ
Q
ELLE
G
KPK
P
N
NSE
L
V
V
--
--
R
N
W
YNPNLD
YK
WF
V
VP
S
L
IA
M
I
--
T
T
I
GVM
I
V
T
S
LSV
A
RERE
Q
GT
L
DQ
LLV
S
P
L
T
TW
Q
I
F
I
GK
-
---
A
V
P
A
L
I
V
AT
F
QAT
I
V
LAIGIW
A
Y
QI
P
FA
GS
LA
LF
Y
F
TMV
I
Y
GLSL
V
G
F
GLLIS
S
LCS
T
Q
Q
QA
FI
GV
F
V
F
-
M
M
PA
IL
LSG
YVS
PVE
N
MP
---
V
W
L
Q
N
LTWIN
P
I
R
HF
TD
I
T
K
Q
I
YL
K
D
A
S
L
D
IVW
NS
L
W
PLL
V
I
TATTGSA
AY
AM
FR
RKV
M
fig|562.372.peg.1110
Escherichia coli 1212A
MFHRL
WT
L
I
RKEL
Q
SLLR
E
P
QTRAILILPV
L
I
Q
V
I
L
F
P
F
AA
T
L
---------
E
V
T
NA
T
IAI
Y
D
E
D
N
GEH
S
VEL
T
QR
F
A
R
ASA
F
THV
L
L
L
K
S
P
Q
E
I
R
PT
I
D
TQ
KA
L
L
LV
R
F
P
AD
F
S
R
KL
D
TFQ
T
A
P
L
Q
L
-
-
I
L
DG
RNS
N
S
A
Q
I
AA
N
Y
L
Q
Q
I
VKNYQ
Q
ELLE
G
KPK
P
N
NSE
L
V
V
--
--
R
N
W
YNPNLD
YK
WF
V
VP
S
L
IA
M
I
--
T
T
I
GVM
I
V
T
S
LSV
A
RERE
Q
GT
L
DQ
LLV
S
P
L
T
TW
Q
I
F
I
GK
-
---
A
V
P
A
L
I
V
AT
F
QAT
I
V
LAIGIW
A
Y
QI
P
FA
GS
LA
LF
Y
F
TMV
I
Y
GLSL
V
G
F
GLLIS
S
LCS
T
Q
Q
QA
FI
GV
F
V
F
-
M
M
PA
IL
LSG
YVS
PVE
N
MP
---
V
W
L
Q
N
LTWIN
P
I
R
HF
TD
I
T
K
Q
I
YL
K
D
A
S
L
D
IVW
NS
L
W
PLL
V
I
TATTGSA
AY
AM
FR
RKV
M
fig|670888.3.peg.1351
Escherichia coli 1827-70
MFHRL
WT
L
I
RKEL
Q
SLLR
E
P
QTRAILILPV
L
I
Q
V
I
L
F
P
F
AA
T
L
---------
E
V
T
NA
T
IAI
Y
D
E
D
N
GEH
S
VEL
T
QR
F
A
R
ASA
F
THV
L
L
L
K
S
P
Q
E
I
R
PT
I
D
TQ
KA
L
L
LV
R
F
P
AD
F
S
R
KL
D
TFQ
T
A
P
L
Q
L
-
-
I
L
DG
RNS
N
S
A
Q
I
AA
N
Y
L
Q
Q
I
VKNYQ
Q
ELLE
G
KPK
P
N
NSE
L
V
V
--
--
R
N
W
YNPNLD
YK
WF
V
VP
S
L
IA
M
I
--
T
T
I
GVM
I
V
T
S
LSV
A
RERE
Q
GT
L
DQ
LLV
S
P
L
T
TW
Q
I
F
I
GK
-
---
A
V
P
A
L
I
V
AT
F
QAT
I
V
LAIGIW
A
Y
QI
P
FA
GS
LA
LF
Y
F
TMV
I
Y
GLSL
V
G
F
GLLIS
S
LCS
T
Q
Q
QA
FI
GV
F
V
F
-
M
M
PA
IL
LSG
YVS
PVE
N
MP
---
V
W
L
Q
N
LTWIN
P
I
R
HF
TD
I
T
K
Q
I
YL
K
D
A
S
L
D
IVW
NS
L
W
PLL
V
I
TATTGSA
AY
AM
FR
RKV
M
fig|670897.3.peg.4839
Escherichia coli 2362-75
MFHRL
WT
L
I
RKEL
Q
SLLR
E
P
QTRAILILPV
L
I
Q
V
I
L
F
P
F
AA
T
L
---------
E
V
T
NA
T
IAI
Y
D
E
D
N
GEH
S
VEL
T
QR
F
A
R
ASA
F
THV
L
L
L
K
S
P
Q
E
I
R
PT
I
D
TQ
KA
L
L
LV
R
F
P
AD
F
S
R
KL
D
TFQ
T
A
P
L
Q
L
-
-
I
L
DG
RNS
N
S
A
Q
I
AA
N
Y
L
Q
Q
I
VKNYQ
Q
ELLE
G
KPK
P
N
NSE
L
V
V
--
--
R
N
W
YNPNLD
YK
WF
V
VP
S
L
IA
M
I
--
T
T
I
GVM
I
V
T
S
LSV
A
RERE
Q
GT
L
DQ
LLV
S
P
L
T
TW
Q
I
F
I
GK
-
---
A
V
P
A
L
I
V
AT
F
QAT
I
V
LAIGIW
A
Y
QI
P
FA
GS
LA
LF
Y
F
TMV
I
Y
GLSL
V
G
F
GLLIS
S
LCS
T
Q
Q
QA
FI
GV
F
V
F
-
M
M
PA
IL
LSG
YVS
PVE
N
MP
---
V
W
L
Q
N
LTWIN
P
I
R
HF
TD
I
T
K
Q
I
YL
K
D
A
S
L
D
IVW
NS
L
W
PLL
V
I
TATTGSA
AY
AM
FR
RKV
M
fig|362663.8.peg.812
Escherichia coli 536
MFHRL
WT
L
I
RKEL
Q
SLLR
E
P
QTRAILILPV
L
I
Q
V
I
L
F
P
F
AA
T
L
---------
E
V
T
NA
T
IAI
Y
D
E
D
N
GEH
S
VEL
T
QR
F
A
R
ASA
F
THV
L
L
L
K
S
P
Q
E
I
R
PT
I
D
TQ
KA
L
L
LV
R
F
P
AD
F
S
R
KL
D
TFQ
T
A
P
L
Q
L
-
-
I
L
DG
RNS
N
S
A
Q
I
AA
N
Y
L
Q
Q
I
VKNYQ
Q
ELLE
G
KPK
P
N
NSE
L
V
V
--
--
R
N
W
YNPNLD
YK
WF
V
VP
S
L
IA
M
I
--
T
T
I
GVM
I
V
T
S
LSV
A
RERE
Q
GT
L
DQ
LLV
S
P
L
T
TW
Q
I
F
I
GK
-
---
A
V
P
A
L
I
V
AT
F
QAT
I
V
LAIGIW
A
Y
QI
P
FA
GS
LA
LF
Y
F
TMV
I
Y
GLSL
V
G
F
GLLIS
S
LCS
T
Q
Q
QA
FI
GV
F
V
F
-
M
M
PA
IL
LSG
YVS
PVE
N
MP
---
V
W
L
Q
N
LTWIN
P
I
R
HF
TD
I
T
K
Q
I
YL
K
D
A
S
L
D
IVW
NS
L
W
PLL
V
I
TATTGSA
AY
AM
FR
RKV
M
fig|362663.9.peg.812
Escherichia coli 536
MFHRL
WT
L
I
RKEL
Q
SLLR
E
P
QTRAILILPV
L
I
Q
V
I
L
F
P
F
AA
T
L
---------
E
V
T
NA
T
IAI
Y
D
E
D
N
GEH
S
VEL
T
QR
F
A
R
ASA
F
THV
L
L
L
K
S
P
Q
E
I
R
PT
I
D
TQ
KA
L
L
LV
R
F
P
AD
F
S
R
KL
D
TFQ
T
A
P
L
Q
L
-
-
I
L
DG
RNS
N
S
A
Q
I
AA
N
Y
L
Q
Q
I
VKNYQ
Q
ELLE
G
KPK
P
N
NSE
L
V
V
--
--
R
N
W
YNPNLD
YK
WF
V
VP
S
L
IA
M
I
--
T
T
I
GVM
I
V
T
S
LSV
A
RERE
Q
GT
L
DQ
LLV
S
P
L
T
TW
Q
I
F
I
GK
-
---
A
V
P
A
L
I
V
AT
F
QAT
I
V
LAIGIW
A
Y
QI
P
FA
GS
LA
LF
Y
F
TMV
I
Y
GLSL
V
G
F
GLLIS
S
LCS
T
Q
Q
QA
FI
GV
F
V
F
-
M
M
PA
IL
LSG
YVS
PVE
N
MP
---
V
W
L
Q
N
LTWIN
P
I
R
HF
TD
I
T
K
Q
I
YL
K
D
A
S
L
D
IVW
NS
L
W
PLL
V
I
TATTGSA
AY
AM
FR
RKV
M
fig|344610.3.peg.3225
Escherichia coli 53638
MFHRL
WT
L
I
RKEL
Q
SLLR
E
P
QTRAILILPV
L
I
Q
V
I
L
F
P
F
AA
T
L
---------
E
V
T
NA
T
IAI
Y
D
E
D
N
GEH
S
VEL
T
QR
F
A
R
ASA
F
THV
L
L
L
K
S
P
Q
E
I
R
PT
I
D
TQ
KA
L
L
LV
R
F
P
AD
F
S
R
KL
D
TFQ
T
A
P
L
Q
L
-
-
I
L
DG
RNS
N
S
A
Q
I
AA
N
Y
L
Q
Q
I
VKNYQ
Q
ELLE
G
KPK
P
N
NSE
L
V
V
--
--
R
N
W
YNPNLD
YK
WF
V
VP
S
L
IA
M
I
--
T
T
I
GVM
I
V
T
S
LSV
A
RERE
Q
GT
L
DQ
LLV
S
P
L
T
TW
Q
I
F
I
GK
-
---
A
V
P
A
L
I
V
AT
F
QAT
I
V
LAIGIW
A
Y
QI
P
FA
GS
LA
LF
Y
F
TMV
I
Y
GLSL
V
G
F
GLLIS
S
LCS
T
Q
Q
QA
FI
GV
F
V
F
-
M
M
PA
IL
LSG
YVS
PVE
N
MP
---
V
W
L
Q
N
LTWIN
P
I
R
HF
TD
I
T
K
Q
I
YL
K
D
A
S
L
D
IVW
NS
L
W
PLL
V
I
TATTGSA
AY
AM
FR
RKV
M
fig|344610.7.peg.896
Escherichia coli 53638
MFHRL
WT
L
I
RKEL
Q
SLLR
E
P
QTRAILILPV
L
I
Q
V
I
L
F
P
F
AA
T
L
---------
E
V
T
NA
T
IAI
Y
D
E
D
N
GEH
S
VEL
T
QR
F
A
R
ASA
F
THV
L
L
L
K
S
P
Q
E
I
R
PT
I
D
TQ
KA
L
L
LV
R
F
P
AD
F
S
R
KL
D
TFQ
T
A
P
L
Q
L
-
-
I
L
DG
RNS
N
S
A
Q
I
AA
N
Y
L
Q
Q
I
VKNYQ
Q
ELLE
G
KPK
P
N
NSE
L
V
V
--
--
R
N
W
YNPNLD
YK
WF
V
VP
S
L
IA
M
I
--
T
T
I
GVM
I
V
T
S
LSV
A
RERE
Q
GT
L
DQ
LLV
S
P
L
T
TW
Q
I
F
I
GK
-
---
A
V
P
A
L
I
V
AT
F
QAT
I
V
LAIGIW
A
Y
QI
P
FA
GS
LA
LF
Y
F
TMV
I
Y
GLSL
V
G
F
GLLIS
S
LCS
T
Q
Q
QA
FI
GV
F
V
F
-
M
M
PA
IL
LSG
YVS
PVE
N
MP
---
V
W
L
Q
N
LTWIN
P
I
R
HF
TD
I
T
K
Q
I
YL
K
D
A
S
L
D
IVW
NS
L
W
PLL
V
I
TATTGSA
AY
AM
FR
RKV
M
fig|562.374.peg.2644
Escherichia coli 536A
MFHRL
WT
L
I
RKEL
Q
SLLR
E
P
QTRAILILPV
L
I
Q
V
I
L
F
P
F
AA
T
L
---------
E
V
T
NA
T
IAI
Y
D
E
D
N
GEH
S
VEL
T
QR
F
A
R
ASA
F
THV
L
L
L
K
S
P
Q
E
I
R
PT
I
D
TQ
KA
L
L
LV
R
F
P
AD
F
S
R
KL
D
TFQ
T
A
P
L
Q
L
-
-
I
L
DG
RNS
N
S
A
Q
I
AA
N
Y
L
Q
Q
I
VKNYQ
Q
ELLE
G
KPK
P
N
NSE
L
V
V
--
--
R
N
W
YNPNLD
YK
WF
V
VP
S
L
IA
M
I
--
T
T
I
GVM
I
V
T
S
LSV
A
RERE
Q
GT
L
DQ
LLV
S
P
L
T
TW
Q
I
F
I
GK
-
---
A
V
P
A
L
I
V
AT
F
QAT
I
V
LAIGIW
A
Y
QI
P
FA
GS
LA
LF
Y
F
TMV
I
Y
GLSL
V
G
F
GLLIS
S
LCS
T
Q
Q
QA
FI
GV
F
V
F
-
M
M
PA
IL
LSG
YVS
PVE
N
MP
---
V
W
L
Q
N
LTWIN
P
I
R
HF
TD
I
T
K
Q
I
YL
K
D
A
S
L
D
IVW
NS
L
W
PLL
V
I
TATTGSA
AY
AM
FR
RKV
M
fig|585055.6.peg.845
Escherichia coli 55989
MFHRL
WT
L
I
RKEL
Q
SLLR
E
P
QTRAILILPV
L
I
Q
V
I
L
F
P
F
AA
T
L
---------
E
V
T
NA
T
IAI
Y
D
E
D
N
GEH
S
VEL
T
QR
F
A
R
ASA
F
THV
L
L
L
K
S
P
Q
E
I
R
PT
I
D
TQ
KA
L
L
LV
R
F
P
AD
F
S
R
KL
D
TFQ
T
A
P
L
Q
L
-
-
I
L
DG
RNS
N
S
A
Q
I
AA
N
Y
L
Q
Q
I
VKNYQ
Q
ELLE
G
KPK
P
N
NSE
L
V
V
--
--
R
N
W
YNPNLD
YK
WF
V
VP
S
L
IA
M
I
--
T
T
I
GVM
I
V
T
S
LSV
A
RERE
Q
GT
L
DQ
LLV
S
P
L
T
TW
Q
I
F
I
GK
-
---
A
V
P
A
L
I
V
AT
F
QAT
I
V
LAIGIW
A
Y
QI
P
FA
GS
LA
LF
Y
F
TMV
I
Y
GLSL
V
G
F
GLLIS
S
LCS
T
Q
Q
QA
FI
GV
F
V
F
-
M
M
PA
IL
LSG
YVS
PVE
N
MP
---
V
W
L
Q
N
LTWIN
P
I
R
HF
TD
I
T
K
Q
I
YL
K
D
A
S
L
D
IVW
NS
L
W
PLL
V
I
TATTGSA
AY
AM
FR
RKV
M
fig|585055.8.peg.849
Escherichia coli 55989
MFHRL
WT
L
I
RKEL
Q
SLLR
E
P
QTRAILILPV
L
I
Q
V
I
L
F
P
F
AA
T
L
---------
E
V
T
NA
T
IAI
Y
D
E
D
N
GEH
S
VEL
T
QR
F
A
R
ASA
F
THV
L
L
L
K
S
P
Q
E
I
R
PT
I
D
TQ
KA
L
L
LV
R
F
P
AD
F
S
R
KL
D
TFQ
T
A
P
L
Q
L
-
-
I
L
DG
RNS
N
S
A
Q
I
AA
N
Y
L
Q
Q
I
VKNYQ
Q
ELLE
G
KPK
P
N
NSE
L
V
V
--
--
R
N
W
YNPNLD
YK
WF
V
VP
S
L
IA
M
I
--
T
T
I
GVM
I
V
T
S
LSV
A
RERE
Q
GT
L
DQ
LLV
S
P
L
T
TW
Q
I
F
I
GK
-
---
A
V
P
A
L
I
V
AT
F
QAT
I
V
LAIGIW
A
Y
QI
P
FA
GS
LA
LF
Y
F
TMV
I
Y
GLSL
V
G
F
GLLIS
S
LCS
T
Q
Q
QA
FI
GV
F
V
F
-
M
M
PA
IL
LSG
YVS
PVE
N
MP
---
V
W
L
Q
N
LTWIN
P
I
R
HF
TD
I
T
K
Q
I
YL
K
D
A
S
L
D
IVW
NS
L
W
PLL
V
I
TATTGSA
AY
AM
FR
RKV
M
fig|405955.13.peg.750
Escherichia coli APEC O1
MFHRL
WT
L
I
RKEL
Q
SLLR
E
P
QTRAILILPV
L
I
Q
V
I
L
F
P
F
AA
T
L
---------
E
V
T
NA
T
IAI
Y
D
E
D
N
GEH
S
VEL
T
QR
F
A
R
ASA
F
THV
L
L
L
K
S
P
Q
E
I
R
PT
I
D
TQ
KA
L
L
LV
R
F
P
AD
F
S
R
KL
D
TFQ
T
A
P
L
Q
L
-
-
I
L
DG
RNS
N
S
A
Q
I
AA
N
Y
L
Q
Q
I
VKNYQ
Q
ELLE
G
KPK
P
N
NSE
L
V
V
--
--
R
N
W
YNPNLD
YK
WF
V
VP
S
L
IA
M
I
--
T
T
I
GVM
I
V
T
S
LSV
A
RERE
Q
GT
L
DQ
LLV
S
P
L
T
TW
Q
I
F
I
GK
-
---
A
V
P
A
L
I
V
AT
F
QAT
I
V
LAIGIW
A
Y
QI
P
FA
GS
LA
LF
Y
F
TMV
I
Y
GLSL
V
G
F
GLLIS
S
LCS
T
Q
Q
QA
FI
GV
F
V
F
-
M
M
PA
IL
LSG
YVS
PVE
N
MP
---
V
W
L
Q
N
LTWIN
P
I
R
HF
TD
I
T
K
Q
I
YL
K
D
A
S
L
D
IVW
NS
L
W
PLL
V
I
TATTGSA
AY
AM
FR
RKV
M
fig|405955.9.peg.629
Escherichia coli APEC O1
MFHRL
WT
L
I
RKEL
Q
SLLR
E
P
QTRAILILPV
L
I
Q
V
I
L
F
P
F
AA
T
L
---------
E
V
T
NA
T
IAI
Y
D
E
D
N
GEH
S
VEL
T
QR
F
A
R
ASA
F
THV
L
L
L
K
S
P
Q
E
I
R
PT
I
D
TQ
KA
L
L
LV
R
F
P
AD
F
S
R
KL
D
TFQ
T
A
P
L
Q
L
-
-
I
L
DG
RNS
N
S
A
Q
I
AA
N
Y
L
Q
Q
I
VKNYQ
Q
ELLE
G
KPK
P
N
NSE
L
V
V
--
--
R
N
W
YNPNLD
YK
WF
V
VP
S
L
IA
M
I
--
T
T
I
GVM
I
V
T
S
LSV
A
RERE
Q
GT
L
DQ
LLV
S
P
L
T
TW
Q
I
F
I
GK
-
---
A
V
P
A
L
I
V
AT
F
QAT
I
V
LAIGIW
A
Y
QI
P
FA
GS
LA
LF
Y
F
TMV
I
Y
GLSL
V
G
F
GLLIS
S
LCS
T
Q
Q
QA
FI
GV
F
V
F
-
M
M
PA
IL
LSG
YVS
PVE
N
MP
---
V
W
L
Q
N
LTWIN
P
I
R
HF
TD
I
T
K
Q
I
YL
K
D
A
S
L
D
IVW
NS
L
W
PLL
V
I
TATTGSA
AY
AM
FR
RKV
M
fig|481805.3.peg.3064
Escherichia coli ATCC 8739
MFHRL
WT
L
I
RKEL
Q
SLLR
E
P
QTRAILILPV
L
I
Q
V
I
L
F
P
F
AA
T
L
---------
E
V
T
NA
T
IAI
Y
D
E
D
N
GEH
S
VEL
T
QR
F
A
R
ASA
F
THV
L
L
L
K
S
P
Q
E
I
R
PT
I
D
TQ
KA
L
L
LV
R
F
P
AD
F
S
R
KL
D
TFQ
T
A
P
L
Q
L
-
-
I
L
DG
RNS
N
S
A
Q
I
AA
N
Y
L
Q
Q
I
VKNYQ
Q
ELLE
G
KPK
P
N
NSE
L
V
V
--
--
R
N
W
YNPNLD
YK
WF
V
VP
S
L
IA
M
I
--
T
T
I
GVM
I
V
T
S
LSV
A
RERE
Q
GT
L
DQ
LLV
S
P
L
T
TW
Q
I
F
I
GK
-
---
A
V
P
A
L
I
V
AT
F
QAT
I
V
LAIGIW
A
Y
QI
P
FA
GS
LA
LF
Y
F
TMV
I
Y
GLSL
V
G
F
GLLIS
S
LCS
T
Q
Q
QA
FI
GV
F
V
F
-
M
M
PA
IL
LSG
YVS
PVE
N
MP
---
V
W
L
Q
N
LTWIN
P
I
R
HF
TD
I
T
K
Q
I
YL
K
D
A
S
L
D
IVW
NS
L
W
PLL
V
I
TATTGSA
AY
AM
FR
RKV
M
fig|481805.6.peg.3050
Escherichia coli ATCC 8739
MFHRL
WT
L
I
RKEL
Q
SLLR
E
P
QTRAILILPV
L
I
Q
V
I
L
F
P
F
AA
T
L
---------
E
V
T
NA
T
IAI
Y
D
E
D
N
GEH
S
VEL
T
QR
F
A
R
ASA
F
THV
L
L
L
K
S
P
Q
E
I
R
PT
I
D
TQ
KA
L
L
LV
R
F
P
AD
F
S
R
KL
D
TFQ
T
A
P
L
Q
L
-
-
I
L
DG
RNS
N
S
A
Q
I
AA
N
Y
L
Q
Q
I
VKNYQ
Q
ELLE
G
KPK
P
N
NSE
L
V
V
--
--
R
N
W
YNPNLD
YK
WF
V
VP
S
L
IA
M
I
--
T
T
I
GVM
I
V
T
S
LSV
A
RERE
Q
GT
L
DQ
LLV
S
P
L
T
TW
Q
I
F
I
GK
-
---
A
V
P
A
L
I
V
AT
F
QAT
I
V
LAIGIW
A
Y
QI
P
FA
GS
LA
LF
Y
F
TMV
I
Y
GLSL
V
G
F
GLLIS
S
LCS
T
Q
Q
QA
FI
GV
F
V
F
-
M
M
PA
IL
LSG
YVS
PVE
N
MP
---
V
W
L
Q
N
LTWIN
P
I
R
HF
TD
I
T
K
Q
I
YL
K
D
A
S
L
D
IVW
NS
L
W
PLL
V
I
TATTGSA
AY
AM
FR
RKV
M
fig|413997.3.peg.801
Escherichia coli B str. REL606
MFHRL
WT
L
I
RKEL
Q
SLLR
E
P
QTRAILILPV
L
I
Q
V
I
L
F
P
F
AA
T
L
---------
E
V
T
NA
T
IAI
Y
D
E
D
N
GEH
S
VEL
T
QR
F
A
R
ASA
F
THV
L
L
L
K
S
P
Q
E
I
R
PT
I
D
TQ
KA
L
L
LV
R
F
P
AD
F
S
R
KL
D
TFQ
T
A
P
L
Q
L
-
-
I
L
DG
RNS
N
S
A
Q
I
AA
N
Y
L
Q
Q
I
VKNYQ
Q
ELLE
G
KPK
P
N
NSE
L
V
V
--
--
R
N
W
YNPNLD
YK
WF
V
VP
S
L
IA
M
I
--
T
T
I
GVM
I
V
T
S
LSV
A
RERE
Q
GT
L
DQ
LLV
S
P
L
T
TW
Q
I
F
I
GK
-
---
A
V
P
A
L
I
V
AT
F
QAT
I
V
LAIGIW
A
Y
QI
P
FA
GS
LA
LF
Y
F
TMV
I
Y
GLSL
V
G
F
GLLIS
S
LCS
T
Q
Q
QA
FI
GV
F
V
F
-
M
M
PA
IL
LSG
YVS
PVE
N
MP
---
V
W
L
Q
N
LTWIN
P
I
R
HF
TD
I
T
K
Q
I
YL
K
D
A
S
L
D
IVW
NS
L
W
PLL
V
I
TATTGSA
AY
AM
FR
RKV
M
fig|550672.3.peg.1029
Escherichia coli B088
MFHRL
WT
L
I
RKEL
Q
SLLR
E
P
QTRAILILPV
L
I
Q
V
I
L
F
P
F
AA
T
L
---------
E
V
T
NA
T
IAI
Y
D
E
D
N
GEH
S
VEL
T
QR
F
A
R
ASA
F
THV
L
L
L
K
S
P
Q
E
I
R
PT
I
D
TQ
KA
L
L
LV
R
F
P
AD
F
S
R
KL
D
TFQ
T
A
P
L
Q
L
-
-
I
L
DG
RNS
N
S
A
Q
I
AA
N
Y
L
Q
Q
I
VKNYQ
Q
ELLE
G
KPK
P
N
NSE
L
V
V
--
--
R
N
W
YNPNLD
YK
WF
V
VP
S
L
IA
M
I
--
T
T
I
GVM
I
V
T
S
LSV
A
RERE
Q
GT
L
DQ
LLV
S
P
L
T
TW
Q
I
F
I
GK
-
---
A
V
P
A
L
I
V
AT
F
QAT
I
V
LAIGIW
A
Y
QI
P
FA
GS
LA
LF
Y
F
TMV
I
Y
GLSL
V
G
F
GLLIS
S
LCS
T
Q
Q
QA
FI
GV
F
V
F
-
M
M
PA
IL
LSG
YVS
PVE
N
MP
---
V
W
L
Q
N
LTWIN
P
I
R
HF
TD
I
T
K
Q
I
YL
K
D
A
S
L
D
IVW
NS
L
W
PLL
V
I
TATTGSA
AY
AM
FR
RKV
M
fig|344601.3.peg.2549
Escherichia coli B171
MFHRL
WT
L
I
RKEL
Q
SLLR
E
P
QTRAILILPV
L
I
Q
V
I
L
F
P
F
AA
T
L
---------
E
V
T
NA
T
IAI
Y
D
E
D
N
GEH
S
VEL
T
QR
F
A
R
ASA
F
THV
L
L
L
K
S
P
Q
E
I
R
PT
I
D
TQ
KA
L
L
LV
R
F
P
AD
F
S
R
KL
D
TFQ
T
A
P
L
Q
L
-
-
I
L
DG
RNS
N
S
A
Q
I
AA
N
Y
L
Q
Q
I
VKNYQ
Q
ELLE
G
KPK
P
N
NSE
L
V
V
--
--
R
N
W
YNPNLD
YK
WF
V
VP
S
L
IA
M
I
--
T
T
I
GVM
I
V
T
S
LSV
A
RERE
Q
GT
L
DQ
LLV
S
P
L
T
TW
Q
I
F
I
GK
-
---
A
V
P
A
L
I
V
AT
F
QAT
I
V
LAIGIW
A
Y
QI
P
FA
GS
LA
LF
Y
F
TMV
I
Y
GLSL
V
G
F
GLLIS
S
LCS
T
Q
Q
QA
FI
GV
F
V
F
-
M
M
PA
IL
LSG
YVS
PVE
N
MP
---
V
W
L
Q
N
LTWIN
P
I
R
HF
TD
I
T
K
Q
I
YL
K
D
A
S
L
D
IVW
NS
L
W
PLL
V
I
TATTGSA
AY
AM
FR
RKV
M
fig|344601.5.peg.2652
Escherichia coli B171
MFHRL
WT
L
I
RKEL
Q
SLLR
E
P
QTRAILILPV
L
I
Q
V
I
L
F
P
F
AA
T
L
---------
E
V
T
NA
T
IAI
Y
D
E
D
N
GEH
S
VEL
T
QR
F
A
R
ASA
F
THV
L
L
L
K
S
P
Q
E
I
R
PT
I
D
TQ
KA
L
L
LV
R
F
P
AD
F
S
R
KL
D
TFQ
T
A
P
L
Q
L
-
-
I
L
DG
RNS
N
S
A
Q
I
AA
N
Y
L
Q
Q
I
VKNYQ
Q
ELLE
G
KPK
P
N
NSE
L
V
V
--
--
R
N
W
YNPNLD
YK
WF
V
VP
S
L
IA
M
I
--
T
T
I
GVM
I
V
T
S
LSV
A
RERE
Q
GT
L
DQ
LLV
S
P
L
T
TW
Q
I
F
I
GK
-
---
A
V
P
A
L
I
V
AT
F
QAT
I
V
LAIGIW
A
Y
QI
P
FA
GS
LA
LF
Y
F
TMV
I
Y
GLSL
V
G
F
GLLIS
S
LCS
T
Q
Q
QA
FI
GV
F
V
F
-
M
M
PA
IL
LSG
YVS
PVE
N
MP
---
V
W
L
Q
N
LTWIN
P
I
R
HF
TD
I
T
K
Q
I
YL
K
D
A
S
L
D
IVW
NS
L
W
PLL
V
I
TATTGSA
AY
AM
FR
RKV
M
fig|550677.3.peg.2060
Escherichia coli B354
MFHRL
WT
L
I
RKEL
Q
SLLR
E
P
QTRAILILPV
L
I
Q
V
I
L
F
P
F
AA
T
L
---------
E
V
T
NA
T
IAI
Y
D
E
D
N
GEH
S
VEL
T
QR
F
A
R
ASA
F
THV
L
L
L
K
S
P
Q
E
I
R
PT
I
D
TQ
KA
L
L
LV
R
F
P
AD
F
S
R
KL
D
TFQ
T
A
P
L
Q
L
-
-
I
L
DG
RNS
N
S
A
Q
I
AA
N
Y
L
Q
Q
I
VKNYQ
Q
ELLE
G
KPK
P
N
NSE
L
V
V
--
--
R
N
W
YNPNLD
YK
WF
V
VP
S
L
IA
M
I
--
T
T
I
GVM
I
V
T
S
LSV
A
RERE
Q
GT
L
DQ
LLV
S
P
L
T
TW
Q
I
F
I
GK
-
---
A
V
P
A
L
I
V
AT
F
QAT
I
V
LAIGIW
A
Y
QI
P
FA
GS
LA
LF
Y
F
TMV
I
Y
GLSL
V
G
F
GLLIS
S
LCS
T
Q
Q
QA
FI
GV
F
V
F
-
M
M
PA
IL
LSG
YVS
PVE
N
MP
---
V
W
L
Q
N
LTWIN
P
I
R
HF
TD
I
T
K
Q
I
YL
K
D
A
S
L
D
IVW
NS
L
W
PLL
V
I
TATTGSA
AY
AM
FR
RKV
M
fig|340184.3.peg.4432
Escherichia coli B7A
MFHRL
WT
L
I
RKEL
Q
SLLR
E
P
QTRAILILPV
L
I
Q
V
I
L
F
P
F
AA
T
L
---------
E
V
T
NA
T
IAI
Y
D
E
D
N
GEH
S
VEL
T
QR
F
A
R
ASA
F
THV
L
L
L
K
S
P
Q
E
I
R
PT
I
D
TQ
KA
L
L
LV
R
F
P
AD
F
S
R
KL
D
TFQ
T
A
P
L
Q
L
-
-
I
L
DG
RNS
N
S
A
Q
I
AA
N
Y
L
Q
Q
I
VKNYQ
Q
ELLE
G
KPK
P
N
NSE
L
V
V
--
--
R
N
W
YNPNLD
YK
WF
V
VP
S
L
IA
M
I
--
T
T
I
GVM
I
V
T
S
LSV
A
RERE
Q
GT
L
DQ
LLV
S
P
L
T
TW
Q
I
F
I
GK
-
---
A
V
P
A
L
I
V
AT
F
QAT
I
V
LAIGIW
A
Y
QI
P
FA
GS
LA
LF
Y
F
TMV
I
Y
GLSL
V
G
F
GLLIS
S
LCS
T
Q
Q
QA
FI
GV
F
V
F
-
M
M
PA
IL
LSG
YVS
PVE
N
MP
---
V
W
L
Q
N
LTWIN
P
I
R
HF
TD
I
T
K
Q
I
YL
K
D
A
S
L
D
IVW
NS
L
W
PLL
V
I
TATTGSA
AY
AM
FR
RKV
M
fig|340184.6.peg.4642
Escherichia coli B7A
MFHRL
WT
L
I
RKEL
Q
SLLR
E
P
QTRAILILPV
L
I
Q
V
I
L
F
P
F
AA
T
L
---------
E
V
T
NA
T
IAI
Y
D
E
D
N
GEH
S
VEL
T
QR
F
A
R
ASA
F
THV
L
L
L
K
S
P
Q
E
I
R
PT
I
D
TQ
KA
L
L
LV
R
F
P
AD
F
S
R
KL
D
TFQ
T
A
P
L
Q
L
-
-
I
L
DG
RNS
N
S
A
Q
I
AA
N
Y
L
Q
Q
I
VKNYQ
Q
ELLE
G
KPK
P
N
NSE
L
V
V
--
--
R
N
W
YNPNLD
YK
WF
V
VP
S
L
IA
M
I
--
T
T
I
GVM
I
V
T
S
LSV
A
RERE
Q
GT
L
DQ
LLV
S
P
L
T
TW
Q
I
F
I
GK
-
---
A
V
P
A
L
I
V
AT
F
QAT
I
V
LAIGIW
A
Y
QI
P
FA
GS
LA
LF
Y
F
TMV
I
Y
GLSL
V
G
F
GLLIS
S
LCS
T
Q
Q
QA
FI
GV
F
V
F
-
M
M
PA
IL
LSG
YVS
PVE
N
MP
---
V
W
L
Q
N
LTWIN
P
I
R
HF
TD
I
T
K
Q
I
YL
K
D
A
S
L
D
IVW
NS
L
W
PLL
V
I
TATTGSA
AY
AM
FR
RKV
M
fig|511693.5.peg.829
Escherichia coli BL21
MFHRL
WT
L
I
RKEL
Q
SLLR
E
P
QTRAILILPV
L
I
Q
V
I
L
F
P
F
AA
T
L
---------
E
V
T
NA
T
IAI
Y
D
E
D
N
GEH
S
VEL
T
QR
F
A
R
ASA
F
THV
L
L
L
K
S
P
Q
E
I
R
PT
I
D
TQ
KA
L
L
LV
R
F
P
AD
F
S
R
KL
D
TFQ
T
A
P
L
Q
L
-
-
I
L
DG
RNS
N
S
A
Q
I
AA
N
Y
L
Q
Q
I
VKNYQ
Q
ELLE
G
KPK
P
N
NSE
L
V
V
--
--
R
N
W
YNPNLD
YK
WF
V
VP
S
L
IA
M
I
--
T
T
I
GVM
I
V
T
S
LSV
A
RERE
Q
GT
L
DQ
LLV
S
P
L
T
TW
Q
I
F
I
GK
-
---
A
V
P
A
L
I
V
AT
F
QAT
I
V
LAIGIW
A
Y
QI
P
FA
GS
LA
LF
Y
F
TMV
I
Y
GLSL
V
G
F
GLLIS
S
LCS
T
Q
Q
QA
FI
GV
F
V
F
-
M
M
PA
IL
LSG
YVS
PVE
N
MP
---
V
W
L
Q
N
LTWIN
P
I
R
HF
TD
I
T
K
Q
I
YL
K
D
A
S
L
D
IVW
NS
L
W
PLL
V
I
TATTGSA
AY
AM
FR
RKV
M
fig|469008.4.peg.2932
Escherichia coli BL21(DE3)
MFHRL
WT
L
I
RKEL
Q
SLLR
E
P
QTRAILILPV
L
I
Q
V
I
L
F
P
F
AA
T
L
---------
E
V
T
NA
T
IAI
Y
D
E
D
N
GEH
S
VEL
T
QR
F
A
R
ASA
F
THV
L
L
L
K
S
P
Q
E
I
R
PT
I
D
TQ
KA
L
L
LV
R
F
P
AD
F
S
R
KL
D
TFQ
T
A
P
L
Q
L
-
-
I
L
DG
RNS
N
S
A
Q
I
AA
N
Y
L
Q
Q
I
VKNYQ
Q
ELLE
G
KPK
P
N
NSE
L
V
V
--
--
R
N
W
YNPNLD
YK
WF
V
VP
S
L
IA
M
I
--
T
T
I
GVM
I
V
T
S
LSV
A
RERE
Q
GT
L
DQ
LLV
S
P
L
T
TW
Q
I
F
I
GK
-
---
A
V
P
A
L
I
V
AT
F
QAT
I
V
LAIGIW
A
Y
QI
P
FA
GS
LA
LF
Y
F
TMV
I
Y
GLSL
V
G
F
GLLIS
S
LCS
T
Q
Q
QA
FI
GV
F
V
F
-
M
M
PA
IL
LSG
YVS
PVE
N
MP
---
V
W
L
Q
N
LTWIN
P
I
R
HF
TD
I
T
K
Q
I
YL
K
D
A
S
L
D
IVW
NS
L
W
PLL
V
I
TATTGSA
AY
AM
FR
RKV
M
fig|595496.3.peg.714
Escherichia coli BW2952
MFHRL
WT
L
I
RKEL
Q
SLLR
E
P
QTRAILILPV
L
I
Q
V
I
L
F
P
F
AA
T
L
---------
E
V
T
NA
T
IAI
Y
D
E
D
N
GEH
S
VEL
T
QR
F
A
R
ASA
F
THV
L
L
L
K
S
P
Q
E
I
R
PT
I
D
TQ
KA
L
L
LV
R
F
P
AD
F
S
R
KL
D
TFQ
T
A
P
L
Q
L
-
-
I
L
DG
RNS
N
S
A
Q
I
AA
N
Y
L
Q
Q
I
VKNYQ
Q
ELLE
G
KPK
P
N
NSE
L
V
V
--
--
R
N
W
YNPNLD
YK
WF
V
VP
S
L
IA
M
I
--
T
T
I
GVM
I
V
T
S
LSV
A
RERE
Q
GT
L
DQ
LLV
S
P
L
T
TW
Q
I
F
I
GK
-
---
A
V
P
A
L
I
V
AT
F
QAT
I
V
LAIGIW
A
Y
QI
P
FA
GS
LA
LF
Y
F
TMV
I
Y
GLSL
V
G
F
GLLIS
S
LCS
T
Q
Q
QA
FI
GV
F
V
F
-
M
M
PA
IL
LSG
YVS
PVE
N
MP
---
V
W
L
Q
N
LTWIN
P
I
R
HF
TD
I
T
K
Q
I
YL
K
D
A
S
L
D
IVW
NS
L
W
PLL
V
I
TATTGSA
AY
AM
FR
RKV
M
fig|536056.3.peg.3008
Escherichia coli DH1
MFHRL
WT
L
I
RKEL
Q
SLLR
E
P
QTRAILILPV
L
I
Q
V
I
L
F
P
F
AA
T
L
---------
E
V
T
NA
T
IAI
Y
D
E
D
N
GEH
S
VEL
T
QR
F
A
R
ASA
F
THV
L
L
L
K
S
P
Q
E
I
R
PT
I
D
TQ
KA
L
L
LV
R
F
P
AD
F
S
R
KL
D
TFQ
T
A
P
L
Q
L
-
-
I
L
DG
RNS
N
S
A
Q
I
AA
N
Y
L
Q
Q
I
VKNYQ
Q
ELLE
G
KPK
P
N
NSE
L
V
V
--
--
R
N
W
YNPNLD
YK
WF
V
VP
S
L
IA
M
I
--
T
T
I
GVM
I
V
T
S
LSV
A
RERE
Q
GT
L
DQ
LLV
S
P
L
T
TW
Q
I
F
I
GK
-
---
A
V
P
A
L
I
V
AT
F
QAT
I
V
LAIGIW
A
Y
QI
P
FA
GS
LA
LF
Y
F
TMV
I
Y
GLSL
V
G
F
GLLIS
S
LCS
T
Q
Q
QA
FI
GV
F
V
F
-
M
M
PA
IL
LSG
YVS
PVE
N
MP
---
V
W
L
Q
N
LTWIN
P
I
R
HF
TD
I
T
K
Q
I
YL
K
D
A
S
L
D
IVW
NS
L
W
PLL
V
I
TATTGSA
AY
AM
FR
RKV
M
fig|340186.3.peg.2595
Escherichia coli E110019
MFHRL
WT
L
I
RKEL
Q
SLLR
E
P
QTRAILILPV
L
I
Q
V
I
L
F
P
F
AA
T
L
---------
E
V
T
NA
T
IAI
Y
D
E
D
N
GEH
S
VEL
T
QR
F
A
R
ASA
F
THV
L
L
L
K
S
P
Q
E
I
R
PT
I
D
TQ
KA
L
L
LV
R
F
P
AD
F
S
R
KL
D
TFQ
T
A
P
L
Q
L
-
-
I
L
DG
RNS
N
S
A
Q
I
AA
N
Y
L
Q
Q
I
VKNYQ
Q
ELLE
G
KPK
P
N
NSE
L
V
V
--
--
R
N
W
YNPNLD
YK
WF
V
VP
S
L
IA
M
I
--
T
T
I
GVM
I
V
T
S
LSV
A
RERE
Q
GT
L
DQ
LLV
S
P
L
T
TW
Q
I
F
I
GK
-
---
A
V
P
A
L
I
V
AT
F
QAT
I
V
LAIGIW
A
Y
QI
P
FA
GS
LA
LF
Y
F
TMV
I
Y
GLSL
V
G
F
GLLIS
S
LCS
T
Q
Q
QA
FI
GV
F
V
F
-
M
M
PA
IL
LSG
YVS
PVE
N
MP
---
V
W
L
Q
N
LTWIN
P
I
R
HF
TD
I
T
K
Q
I
YL
K
D
A
S
L
D
IVW
NS
L
W
PLL
V
I
TATTGSA
AY
AM
FR
RKV
M
fig|340186.5.peg.2682
Escherichia coli E110019
MFHRL
WT
L
I
RKEL
Q
SLLR
E
P
QTRAILILPV
L
I
Q
V
I
L
F
P
F
AA
T
L
---------
E
V
T
NA
T
IAI
Y
D
E
D
N
GEH
S
VEL
T
QR
F
A
R
ASA
F
THV
L
L
L
K
S
P
Q
E
I
R
PT
I
D
TQ
KA
L
L
LV
R
F
P
AD
F
S
R
KL
D
TFQ
T
A
P
L
Q
L
-
-
I
L
DG
RNS
N
S
A
Q
I
AA
N
Y
L
Q
Q
I
VKNYQ
Q
ELLE
G
KPK
P
N
NSE
L
V
V
--
--
R
N
W
YNPNLD
YK
WF
V
VP
S
L
IA
M
I
--
T
T
I
GVM
I
V
T
S
LSV
A
RERE
Q
GT
L
DQ
LLV
S
P
L
T
TW
Q
I
F
I
GK
-
---
A
V
P
A
L
I
V
AT
F
QAT
I
V
LAIGIW
A
Y
QI
P
FA
GS
LA
LF
Y
F
TMV
I
Y
GLSL
V
G
F
GLLIS
S
LCS
T
Q
Q
QA
FI
GV
F
V
F
-
M
M
PA
IL
LSG
YVS
PVE
N
MP
---
V
W
L
Q
N
LTWIN
P
I
R
HF
TD
I
T
K
Q
I
YL
K
D
A
S
L
D
IVW
NS
L
W
PLL
V
I
TATTGSA
AY
AM
FR
RKV
M
fig|340185.3.peg.2866
Escherichia coli E22
MFHRL
WT
L
I
RKEL
Q
SLLR
E
P
QTRAILILPV
L
I
Q
V
I
L
F
P
F
AA
T
L
---------
E
V
T
NA
T
IAI
Y
D
E
D
N
GEH
S
VEL
T
QR
F
A
R
ASA
F
THV
L
L
L
K
S
P
Q
E
I
R
PT
I
D
TQ
KA
L
L
LV
R
F
P
AD
F
S
R
KL
D
TFQ
T
A
P
L
Q
L
-
-
I
L
DG
RNS
N
S
A
Q
I
AA
N
Y
L
Q
Q
I
VKNYQ
Q
ELLE
G
KPK
P
N
NSE
L
V
V
--
--
R
N
W
YNPNLD
YK
WF
V
VP
S
L
IA
M
I
--
T
T
I
GVM
I
V
T
S
LSV
A
RERE
Q
GT
L
DQ
LLV
S
P
L
T
TW
Q
I
F
I
GK
-
---
A
V
P
A
L
I
V
AT
F
QAT
I
V
LAIGIW
A
Y
QI
P
FA
GS
LA
LF
Y
F
TMV
I
Y
GLSL
V
G
F
GLLIS
S
LCS
T
Q
Q
QA
FI
GV
F
V
F
-
M
M
PA
IL
LSG
YVS
PVE
N
MP
---
V
W
L
Q
N
LTWIN
P
I
R
HF
TD
I
T
K
Q
I
YL
K
D
A
S
L
D
IVW
NS
L
W
PLL
V
I
TATTGSA
AY
AM
FR
RKV
M
fig|340185.4.peg.3018
Escherichia coli E22
MFHRL
WT
L
I
RKEL
Q
SLLR
E
P
QTRAILILPV
L
I
Q
V
I
L
F
P
F
AA
T
L
---------
E
V
T
NA
T
IAI
Y
D
E
D
N
GEH
S
VEL
T
QR
F
A
R
ASA
F
THV
L
L
L
K
S
P
Q
E
I
R
PT
I
D
TQ
KA
L
L
LV
R
F
P
AD
F
S
R
KL
D
TFQ
T
A
P
L
Q
L
-
-
I
L
DG
RNS
N
S
A
Q
I
AA
N
Y
L
Q
Q
I
VKNYQ
Q
ELLE
G
KPK
P
N
NSE
L
V
V
--
--
R
N
W
YNPNLD
YK
WF
V
VP
S
L
IA
M
I
--
T
T
I
GVM
I
V
T
S
LSV
A
RERE
Q
GT
L
DQ
LLV
S
P
L
T
TW
Q
I
F
I
GK
-
---
A
V
P
A
L
I
V
AT
F
QAT
I
V
LAIGIW
A
Y
QI
P
FA
GS
LA
LF
Y
F
TMV
I
Y
GLSL
V
G
F
GLLIS
S
LCS
T
Q
Q
QA
FI
GV
F
V
F
-
M
M
PA
IL
LSG
YVS
PVE
N
MP
---
V
W
L
Q
N
LTWIN
P
I
R
HF
TD
I
T
K
Q
I
YL
K
D
A
S
L
D
IVW
NS
L
W
PLL
V
I
TATTGSA
AY
AM
FR
RKV
M
fig|216593.1.peg.1386
Escherichia coli E2348/69
MFHRL
WT
L
I
RKEL
Q
SLLR
E
P
QTRAILILPV
L
I
Q
V
I
L
F
P
F
AA
T
L
---------
E
V
T
NA
T
IAI
Y
D
E
D
N
GEH
S
VEL
T
QR
F
A
R
ASA
F
THV
L
L
L
K
S
P
Q
E
I
R
PT
I
D
TQ
KA
L
L
LV
R
F
P
AD
F
S
R
KL
D
TFQ
T
A
P
L
Q
L
-
-
I
L
DG
RNS
N
S
A
Q
I
AA
N
Y
L
Q
Q
I
VKNYQ
Q
ELLE
G
KPK
P
N
NSE
L
V
V
--
--
R
N
W
YNPNLD
YK
WF
V
VP
S
L
IA
M
I
--
T
T
I
GVM
I
V
T
S
LSV
A
RERE
Q
GT
L
DQ
LLV
S
P
L
T
TW
Q
I
F
I
GK
-
---
A
V
P
A
L
I
V
AT
F
QAT
I
V
LAIGIW
A
Y
QI
P
FA
GS
LA
LF
Y
F
TMV
I
Y
GLSL
V
G
F
GLLIS
S
LCS
T
Q
Q
QA
FI
GV
F
V
F
-
M
M
PA
IL
LSG
YVS
PVE
N
MP
---
V
W
L
Q
N
LTWIN
P
I
R
HF
TD
I
T
K
Q
I
YL
K
D
A
S
L
D
IVW
NS
L
W
PLL
V
I
TATTGSA
AY
AM
FR
RKV
M
fig|562.375.peg.4381
Escherichia coli EC4100B
MFHRL
WT
L
I
RKEL
Q
SLLR
E
P
QTRAILILPV
L
I
Q
V
I
L
F
P
F
AA
T
L
---------
E
V
T
NA
T
IAI
Y
D
E
D
N
GEH
S
VEL
T
QR
F
A
R
ASA
F
THV
L
L
L
K
S
P
Q
E
I
R
PT
I
D
TQ
KA
L
L
LV
R
F
P
AD
F
S
R
KL
D
TFQ
T
A
P
L
Q
L
-
-
I
L
DG
RNS
N
S
A
Q
I
AA
N
Y
L
Q
Q
I
VKNYQ
Q
ELLE
G
KPK
P
N
NSE
L
V
V
--
--
R
N
W
YNPNLD
YK
WF
V
VP
S
L
IA
M
I
--
T
T
I
GVM
I
V
T
S
LSV
A
RERE
Q
GT
L
DQ
LLV
S
P
L
T
TW
Q
I
F
I
GK
-
---
A
V
P
A
L
I
V
AT
F
QAT
I
V
LAIGIW
A
Y
QI
P
FA
GS
LA
LF
Y
F
TMV
I
Y
GLSL
V
G
F
GLLIS
S
LCS
T
Q
Q
QA
FI
GV
F
V
F
-
M
M
PA
IL
LSG
YVS
PVE
N
MP
---
V
W
L
Q
N
LTWIN
P
I
R
HF
TD
I
T
K
Q
I
YL
K
D
A
S
L
D
IVW
NS
L
W
PLL
V
I
TATTGSA
AY
AM
FR
RKV
M
fig|316401.4.peg.996
Escherichia coli ETEC H10407
MFHRL
WT
L
I
RKEL
Q
SLLR
E
P
QTRAILILPV
L
I
Q
V
I
L
F
P
F
AA
T
L
---------
E
V
T
NA
T
IAI
Y
D
E
D
N
GEH
S
VEL
T
QR
F
A
R
ASA
F
THV
L
L
L
K
S
P
Q
E
I
R
PT
I
D
TQ
KA
L
L
LV
R
F
P
AD
F
S
R
KL
D
TFQ
T
A
P
L
Q
L
-
-
I
L
DG
RNS
N
S
A
Q
I
AA
N
Y
L
Q
Q
I
VKNYQ
Q
ELLE
G
KPK
P
N
NSE
L
V
V
--
--
R
N
W
YNPNLD
YK
WF
V
VP
S
L
IA
M
I
--
T
T
I
GVM
I
V
T
S
LSV
A
RERE
Q
GT
L
DQ
LLV
S
P
L
T
TW
Q
I
F
I
GK
-
---
A
V
P
A
L
I
V
AT
F
QAT
I
V
LAIGIW
A
Y
QI
P
FA
GS
LA
LF
Y
F
TMV
I
Y
GLSL
V
G
F
GLLIS
S
LCS
T
Q
Q
QA
FI
GV
F
V
F
-
M
M
PA
IL
LSG
YVS
PVE
N
MP
---
V
W
L
Q
N
LTWIN
P
I
R
HF
TD
I
T
K
Q
I
YL
K
D
A
S
L
D
IVW
NS
L
W
PLL
V
I
TATTGSA
AY
AM
FR
RKV
M
fig|340197.3.peg.4645
Escherichia coli F11
MFHRL
WT
L
I
RKEL
Q
SLLR
E
P
QTRAILILPV
L
I
Q
V
I
L
F
P
F
AA
T
L
---------
E
V
T
NA
T
IAI
Y
D
E
D
N
GEH
S
VEL
T
QR
F
A
R
ASA
F
THV
L
L
L
K
S
P
Q
E
I
R
PT
I
D
TQ
KA
L
L
LV
R
F
P
AD
F
S
R
KL
D
TFQ
T
A
P
L
Q
L
-
-
I
L
DG
RNS
N
S
A
Q
I
AA
N
Y
L
Q
Q
I
VKNYQ
Q
ELLE
G
KPK
P
N
NSE
L
V
V
--
--
R
N
W
YNPNLD
YK
WF
V
VP
S
L
IA
M
I
--
T
T
I
GVM
I
V
T
S
LSV
A
RERE
Q
GT
L
DQ
LLV
S
P
L
T
TW
Q
I
F
I
GK
-
---
A
V
P
A
L
I
V
AT
F
QAT
I
V
LAIGIW
A
Y
QI
P
FA
GS
LA
LF
Y
F
TMV
I
Y
GLSL
V
G
F
GLLIS
S
LCS
T
Q
Q
QA
FI
GV
F
V
F
-
M
M
PA
IL
LSG
YVS
PVE
N
MP
---
V
W
L
Q
N
LTWIN
P
I
R
HF
TD
I
T
K
Q
I
YL
K
D
A
S
L
D
IVW
NS
L
W
PLL
V
I
TATTGSA
AY
AM
FR
RKV
M
fig|340197.5.peg.4848
Escherichia coli F11
MFHRL
WT
L
I
RKEL
Q
SLLR
E
P
QTRAILILPV
L
I
Q
V
I
L
F
P
F
AA
T
L
---------
E
V
T
NA
T
IAI
Y
D
E
D
N
GEH
S
VEL
T
QR
F
A
R
ASA
F
THV
L
L
L
K
S
P
Q
E
I
R
PT
I
D
TQ
KA
L
L
LV
R
F
P
AD
F
S
R
KL
D
TFQ
T
A
P
L
Q
L
-
-
I
L
DG
RNS
N
S
A
Q
I
AA
N
Y
L
Q
Q
I
VKNYQ
Q
ELLE
G
KPK
P
N
NSE
L
V
V
--
--
R
N
W
YNPNLD
YK
WF
V
VP
S
L
IA
M
I
--
T
T
I
GVM
I
V
T
S
LSV
A
RERE
Q
GT
L
DQ
LLV
S
P
L
T
TW
Q
I
F
I
GK
-
---
A
V
P
A
L
I
V
AT
F
QAT
I
V
LAIGIW
A
Y
QI
P
FA
GS
LA
LF
Y
F
TMV
I
Y
GLSL
V
G
F
GLLIS
S
LCS
T
Q
Q
QA
FI
GV
F
V
F
-
M
M
PA
IL
LSG
YVS
PVE
N
MP
---
V
W
L
Q
N
LTWIN
P
I
R
HF
TD
I
T
K
Q
I
YL
K
D
A
S
L
D
IVW
NS
L
W
PLL
V
I
TATTGSA
AY
AM
FR
RKV
M
fig|656379.3.peg.1627
Escherichia coli FVEC1302
MFHRL
WT
L
I
RKEL
Q
SLLR
E
P
QTRAILILPV
L
I
Q
V
I
L
F
P
F
AA
T
L
---------
E
V
T
NA
T
IAI
Y
D
E
D
N
GEH
S
VEL
T
QR
F
A
R
ASA
F
THV
L
L
L
K
S
P
Q
E
I
R
PT
I
D
TQ
KA
L
L
LV
R
F
P
AD
F
S
R
KL
D
TFQ
T
A
P
L
Q
L
-
-
I
L
DG
RNS
N
S
A
Q
I
AA
N
Y
L
Q
Q
I
VKNYQ
Q
ELLE
G
KPK
P
N
NSE
L
V
V
--
--
R
N
W
YNPNLD
YK
WF
V
VP
S
L
IA
M
I
--
T
T
I
GVM
I
V
T
S
LSV
A
RERE
Q
GT
L
DQ
LLV
S
P
L
T
TW
Q
I
F
I
GK
-
---
A
V
P
A
L
I
V
AT
F
QAT
I
V
LAIGIW
A
Y
QI
P
FA
GS
LA
LF
Y
F
TMV
I
Y
GLSL
V
G
F
GLLIS
S
LCS
T
Q
Q
QA
FI
GV
F
V
F
-
M
M
PA
IL
LSG
YVS
PVE
N
MP
---
V
W
L
Q
N
LTWIN
P
I
R
HF
TD
I
T
K
Q
I
YL
K
D
A
S
L
D
IVW
NS
L
W
PLL
V
I
TATTGSA
AY
AM
FR
RKV
M
fig|656380.3.peg.1455
Escherichia coli FVEC1412
MFHRL
WT
L
I
RKEL
Q
SLLR
E
P
QTRAILILPV
L
I
Q
V
I
L
F
P
F
AA
T
L
---------
E
V
T
NA
T
IAI
Y
D
E
D
N
GEH
S
VEL
T
QR
F
A
R
ASA
F
THV
L
L
L
K
S
P
Q
E
I
R
PT
I
D
TQ
KA
L
L
LV
R
F
P
AD
F
S
R
KL
D
TFQ
T
A
P
L
Q
L
-
-
I
L
DG
RNS
N
S
A
Q
I
AA
N
Y
L
Q
Q
I
VKNYQ
Q
ELLE
G
KPK
P
N
NSE
L
V
V
--
--
R
N
W
YNPNLD
YK
WF
V
VP
S
L
IA
M
I
--
T
T
I
GVM
I
V
T
S
LSV
A
RERE
Q
GT
L
DQ
LLV
S
P
L
T
TW
Q
I
F
I
GK
-
---
A
V
P
A
L
I
V
AT
F
QAT
I
V
LAIGIW
A
Y
QI
P
FA
GS
LA
LF
Y
F
TMV
I
Y
GLSL
V
G
F
GLLIS
S
LCS
T
Q
Q
QA
FI
GV
F
V
F
-
M
M
PA
IL
LSG
YVS
PVE
N
MP
---
V
W
L
Q
N
LTWIN
P
I
R
HF
TD
I
T
K
Q
I
YL
K
D
A
S
L
D
IVW
NS
L
W
PLL
V
I
TATTGSA
AY
AM
FR
RKV
M
fig|656393.3.peg.1545
Escherichia coli H299
MFHRL
WT
L
I
RKEL
Q
SLLR
E
P
QTRAILILPV
L
I
Q
V
I
L
F
P
F
AA
T
L
---------
E
V
T
NA
T
IAI
Y
D
E
D
N
GEH
S
VEL
T
QR
F
A
R
ASA
F
THV
L
L
L
K
S
P
Q
E
I
R
PT
I
D
TQ
KA
L
L
LV
R
F
P
AD
F
S
R
KL
D
TFQ
T
A
P
L
Q
L
-
-
I
L
DG
RNS
N
S
A
Q
I
AA
N
Y
L
Q
Q
I
VKNYQ
Q
ELLE
G
KPK
P
N
NSE
L
V
V
--
--
R
N
W
YNPNLD
YK
WF
V
VP
S
L
IA
M
I
--
T
T
I
GVM
I
V
T
S
LSV
A
RERE
Q
GT
L
DQ
LLV
S
P
L
T
TW
Q
I
F
I
GK
-
---
A
V
P
A
L
I
V
AT
F
QAT
I
V
LAIGIW
A
Y
QI
P
FA
GS
LA
LF
Y
F
TMV
I
Y
GLSL
V
G
F
GLLIS
S
LCS
T
Q
Q
QA
FI
GV
F
V
F
-
M
M
PA
IL
LSG
YVS
PVE
N
MP
---
V
W
L
Q
N
LTWIN
P
I
R
HF
TD
I
T
K
Q
I
YL
K
D
A
S
L
D
IVW
NS
L
W
PLL
V
I
TATTGSA
AY
AM
FR
RKV
M
fig|656408.3.peg.792
Escherichia coli H591
MFHRL
WT
L
I
RKEL
Q
SLLR
E
P
QTRAILILPV
L
I
Q
V
I
L
F
P
F
AA
T
L
---------
E
V
T
NA
T
IAI
Y
D
E
D
N
GEH
S
VEL
T
QR
F
A
R
ASA
F
THV
L
L
L
K
S
P
Q
E
I
R
PT
I
D
TQ
KA
L
L
LV
R
F
P
AD
F
S
R
KL
D
TFQ
T
A
P
L
Q
L
-
-
I
L
DG
RNS
N
S
A
Q
I
AA
N
Y
L
Q
Q
I
VKNYQ
Q
ELLE
G
KPK
P
N
NSE
L
V
V
--
--
R
N
W
YNPNLD
YK
WF
V
VP
S
L
IA
M
I
--
T
T
I
GVM
I
V
T
S
LSV
A
RERE
Q
GT
L
DQ
LLV
S
P
L
T
TW
Q
I
F
I
GK
-
---
A
V
P
A
L
I
V
AT
F
QAT
I
V
LAIGIW
A
Y
QI
P
FA
GS
LA
LF
Y
F
TMV
I
Y
GLSL
V
G
F
GLLIS
S
LCS
T
Q
Q
QA
FI
GV
F
V
F
-
M
M
PA
IL
LSG
YVS
PVE
N
MP
---
V
W
L
Q
N
LTWIN
P
I
R
HF
TD
I
T
K
Q
I
YL
K
D
A
S
L
D
IVW
NS
L
W
PLL
V
I
TATTGSA
AY
AM
FR
RKV
M
fig|331112.3.peg.782
Escherichia coli HS
MFHRL
WT
L
I
RKEL
Q
SLLR
E
P
QTRAILILPV
L
I
Q
V
I
L
F
P
F
AA
T
L
---------
E
V
T
NA
T
IAI
Y
D
E
D
N
GEH
S
VEL
T
QR
F
A
R
ASA
F
THV
L
L
L
K
S
P
Q
E
I
R
PT
I
D
TQ
KA
L
L
LV
R
F
P
AD
F
S
R
KL
D
TFQ
T
A
P
L
Q
L
-
-
I
L
DG
RNS
N
S
A
Q
I
AA
N
Y
L
Q
Q
I
VKNYQ
Q
ELLE
G
KPK
P
N
NSE
L
V
V
--
--
R
N
W
YNPNLD
YK
WF
V
VP
S
L
IA
M
I
--
T
T
I
GVM
I
V
T
S
LSV
A
RERE
Q
GT
L
DQ
LLV
S
P
L
T
TW
Q
I
F
I
GK
-
---
A
V
P
A
L
I
V
AT
F
QAT
I
V
LAIGIW
A
Y
QI
P
FA
GS
LA
LF
Y
F
TMV
I
Y
GLSL
V
G
F
GLLIS
S
LCS
T
Q
Q
QA
FI
GV
F
V
F
-
M
M
PA
IL
LSG
YVS
PVE
N
MP
---
V
W
L
Q
N
LTWIN
P
I
R
HF
TD
I
T
K
Q
I
YL
K
D
A
S
L
D
IVW
NS
L
W
PLL
V
I
TATTGSA
AY
AM
FR
RKV
M
fig|331112.6.peg.816
Escherichia coli HS
MFHRL
WT
L
I
RKEL
Q
SLLR
E
P
QTRAILILPV
L
I
Q
V
I
L
F
P
F
AA
T
L
---------
E
V
T
NA
T
IAI
Y
D
E
D
N
GEH
S
VEL
T
QR
F
A
R
ASA
F
THV
L
L
L
K
S
P
Q
E
I
R
PT
I
D
TQ
KA
L
L
LV
R
F
P
AD
F
S
R
KL
D
TFQ
T
A
P
L
Q
L
-
-
I
L
DG
RNS
N
S
A
Q
I
AA
N
Y
L
Q
Q
I
VKNYQ
Q
ELLE
G
KPK
P
N
NSE
L
V
V
--
--
R
N
W
YNPNLD
YK
WF
V
VP
S
L
IA
M
I
--
T
T
I
GVM
I
V
T
S
LSV
A
RERE
Q
GT
L
DQ
LLV
S
P
L
T
TW
Q
I
F
I
GK
-
---
A
V
P
A
L
I
V
AT
F
QAT
I
V
LAIGIW
A
Y
QI
P
FA
GS
LA
LF
Y
F
TMV
I
Y
GLSL
V
G
F
GLLIS
S
LCS
T
Q
Q
QA
FI
GV
F
V
F
-
M
M
PA
IL
LSG
YVS
PVE
N
MP
---
V
W
L
Q
N
LTWIN
P
I
R
HF
TD
I
T
K
Q
I
YL
K
D
A
S
L
D
IVW
NS
L
W
PLL
V
I
TATTGSA
AY
AM
FR
RKV
M
fig|585034.4.peg.814
Escherichia coli IAI1
MFHRL
WT
L
I
RKEL
Q
SLLR
E
P
QTRAILILPV
L
I
Q
V
I
L
F
P
F
AA
T
L
---------
E
V
T
NA
T
IAI
Y
D
E
D
N
GEH
S
VEL
T
QR
F
A
R
ASA
F
THV
L
L
L
K
S
P
Q
E
I
R
PT
I
D
TQ
KA
L
L
LV
R
F
P
AD
F
S
R
KL
D
TFQ
T
A
P
L
Q
L
-
-
I
L
DG
RNS
N
S
A
Q
I
AA
N
Y
L
Q
Q
I
VKNYQ
Q
ELLE
G
KPK
P
N
NSE
L
V
V
--
--
R
N
W
YNPNLD
YK
WF
V
VP
S
L
IA
M
I
--
T
T
I
GVM
I
V
T
S
LSV
A
RERE
Q
GT
L
DQ
LLV
S
P
L
T
TW
Q
I
F
I
GK
-
---
A
V
P
A
L
I
V
AT
F
QAT
I
V
LAIGIW
A
Y
QI
P
FA
GS
LA
LF
Y
F
TMV
I
Y
GLSL
V
G
F
GLLIS
S
LCS
T
Q
Q
QA
FI
GV
F
V
F
-
M
M
PA
IL
LSG
YVS
PVE
N
MP
---
V
W
L
Q
N
LTWIN
P
I
R
HF
TD
I
T
K
Q
I
YL
K
D
A
S
L
D
IVW
NS
L
W
PLL
V
I
TATTGSA
AY
AM
FR
RKV
M
fig|585034.5.peg.811
Escherichia coli IAI1
MFHRL
WT
L
I
RKEL
Q
SLLR
E
P
QTRAILILPV
L
I
Q
V
I
L
F
P
F
AA
T
L
---------
E
V
T
NA
T
IAI
Y
D
E
D
N
GEH
S
VEL
T
QR
F
A
R
ASA
F
THV
L
L
L
K
S
P
Q
E
I
R
PT
I
D
TQ
KA
L
L
LV
R
F
P
AD
F
S
R
KL
D
TFQ
T
A
P
L
Q
L
-
-
I
L
DG
RNS
N
S
A
Q
I
AA
N
Y
L
Q
Q
I
VKNYQ
Q
ELLE
G
KPK
P
N
NSE
L
V
V
--
--
R
N
W
YNPNLD
YK
WF
V
VP
S
L
IA
M
I
--
T
T
I
GVM
I
V
T
S
LSV
A
RERE
Q
GT
L
DQ
LLV
S
P
L
T
TW
Q
I
F
I
GK
-
---
A
V
P
A
L
I
V
AT
F
QAT
I
V
LAIGIW
A
Y
QI
P
FA
GS
LA
LF
Y
F
TMV
I
Y
GLSL
V
G
F
GLLIS
S
LCS
T
Q
Q
QA
FI
GV
F
V
F
-
M
M
PA
IL
LSG
YVS
PVE
N
MP
---
V
W
L
Q
N
LTWIN
P
I
R
HF
TD
I
T
K
Q
I
YL
K
D
A
S
L
D
IVW
NS
L
W
PLL
V
I
TATTGSA
AY
AM
FR
RKV
M
fig|714962.3.peg.798
Escherichia coli IHE3034
MFHRL
WT
L
I
RKEL
Q
SLLR
E
P
QTRAILILPV
L
I
Q
V
I
L
F
P
F
AA
T
L
---------
E
V
T
NA
T
IAI
Y
D
E
D
N
GEH
S
VEL
T
QR
F
A
R
ASA
F
THV
L
L
L
K
S
P
Q
E
I
R
PT
I
D
TQ
KA
L
L
LV
R
F
P
AD
F
S
R
KL
D
TFQ
T
A
P
L
Q
L
-
-
I
L
DG
RNS
N
S
A
Q
I
AA
N
Y
L
Q
Q
I
VKNYQ
Q
ELLE
G
KPK
P
N
NSE
L
V
V
--
--
R
N
W
YNPNLD
YK
WF
V
VP
S
L
IA
M
I
--
T
T
I
GVM
I
V
T
S
LSV
A
RERE
Q
GT
L
DQ
LLV
S
P
L
T
TW
Q
I
F
I
GK
-
---
A
V
P
A
L
I
V
AT
F
QAT
I
V
LAIGIW
A
Y
QI
P
FA
GS
LA
LF
Y
F
TMV
I
Y
GLSL
V
G
F
GLLIS
S
LCS
T
Q
Q
QA
FI
GV
F
V
F
-
M
M
PA
IL
LSG
YVS
PVE
N
MP
---
V
W
L
Q
N
LTWIN
P
I
R
HF
TD
I
T
K
Q
I
YL
K
D
A
S
L
D
IVW
NS
L
W
PLL
V
I
TATTGSA
AY
AM
FR
RKV
M
fig|83333.1.peg.778
Escherichia coli K12
MFHRL
WT
L
I
RKEL
Q
SLLR
E
P
QTRAILILPV
L
I
Q
V
I
L
F
P
F
AA
T
L
---------
E
V
T
NA
T
IAI
Y
D
E
D
N
GEH
S
VEL
T
QR
F
A
R
ASA
F
THV
L
L
L
K
S
P
Q
E
I
R
PT
I
D
TQ
KA
L
L
LV
R
F
P
AD
F
S
R
KL
D
TFQ
T
A
P
L
Q
L
-
-
I
L
DG
RNS
N
S
A
Q
I
AA
N
Y
L
Q
Q
I
VKNYQ
Q
ELLE
G
KPK
P
N
NSE
L
V
V
--
--
R
N
W
YNPNLD
YK
WF
V
VP
S
L
IA
M
I
--
T
T
I
GVM
I
V
T
S
LSV
A
RERE
Q
GT
L
DQ
LLV
S
P
L
T
TW
Q
I
F
I
GK
-
---
A
V
P
A
L
I
V
AT
F
QAT
I
V
LAIGIW
A
Y
QI
P
FA
GS
LA
LF
Y
F
TMV
I
Y
GLSL
V
G
F
GLLIS
S
LCS
T
Q
Q
QA
FI
GV
F
V
F
-
M
M
PA
IL
LSG
YVS
PVE
N
MP
---
V
W
L
Q
N
LTWIN
P
I
R
HF
TD
I
T
K
Q
I
YL
K
D
A
S
L
D
IVW
NS
L
W
PLL
V
I
TATTGSA
AY
AM
FR
RKV
M
fig|595495.4.peg.3233
Escherichia coli KO11
MFHRL
WT
L
I
RKEL
Q
SLLR
E
P
QTRAILILPV
L
I
Q
V
I
L
F
P
F
AA
T
L
---------
E
V
T
NA
T
IAI
Y
D
E
D
N
GEH
S
VEL
T
QR
F
A
R
ASA
F
THV
L
L
L
K
S
P
Q
E
I
R
PT
I
D
TQ
KA
L
L
LV
R
F
P
AD
F
S
R
KL
D
TFQ
T
A
P
L
Q
L
-
-
I
L
DG
RNS
N
S
A
Q
I
AA
N
Y
L
Q
Q
I
VKNYQ
Q
ELLE
G
KPK
P
N
NSE
L
V
V
--
--
R
N
W
YNPNLD
YK
WF
V
VP
S
L
IA
M
I
--
T
T
I
GVM
I
V
T
S
LSV
A
RERE
Q
GT
L
DQ
LLV
S
P
L
T
TW
Q
I
F
I
GK
-
---
A
V
P
A
L
I
V
AT
F
QAT
I
V
LAIGIW
A
Y
QI
P
FA
GS
LA
LF
Y
F
TMV
I
Y
GLSL
V
G
F
GLLIS
S
LCS
T
Q
Q
QA
FI
GV
F
V
F
-
M
M
PA
IL
LSG
YVS
PVE
N
MP
---
V
W
L
Q
N
LTWIN
P
I
R
HF
TD
I
T
K
Q
I
YL
K
D
A
S
L
D
IVW
NS
L
W
PLL
V
I
TATTGSA
AY
AM
FR
RKV
M
fig|656417.3.peg.977
Escherichia coli M605
MFHRL
WT
L
I
RKEL
Q
SLLR
E
P
QTRAILILPV
L
I
Q
V
I
L
F
P
F
AA
T
L
---------
E
V
T
NA
T
IAI
Y
D
E
D
N
GEH
S
VEL
T
QR
F
A
R
ASA
F
THV
L
L
L
K
S
P
Q
E
I
R
PT
I
D
TQ
KA
L
L
LV
R
F
P
AD
F
S
R
KL
D
TFQ
T
A
P
L
Q
L
-
-
I
L
DG
RNS
N
S
A
Q
I
AA
N
Y
L
Q
Q
I
VKNYQ
Q
ELLE
G
KPK
P
N
NSE
L
V
V
--
--
R
N
W
YNPNLD
YK
WF
V
VP
S
L
IA
M
I
--
T
T
I
GVM
I
V
T
S
LSV
A
RERE
Q
GT
L
DQ
LLV
S
P
L
T
TW
Q
I
F
I
GK
-
---
A
V
P
A
L
I
V
AT
F
QAT
I
V
LAIGIW
A
Y
QI
P
FA
GS
LA
LF
Y
F
TMV
I
Y
GLSL
V
G
F
GLLIS
S
LCS
T
Q
Q
QA
FI
GV
F
V
F
-
M
M
PA
IL
LSG
YVS
PVE
N
MP
---
V
W
L
Q
N
LTWIN
P
I
R
HF
TD
I
T
K
Q
I
YL
K
D
A
S
L
D
IVW
NS
L
W
PLL
V
I
TATTGSA
AY
AM
FR
RKV
M
fig|656419.3.peg.1073
Escherichia coli M718
MFHRL
WT
L
I
RKEL
Q
SLLR
E
P
QTRAILILPV
L
I
Q
V
I
L
F
P
F
AA
T
L
---------
E
V
T
NA
T
IAI
Y
D
E
D
N
GEH
S
VEL
T
QR
F
A
R
ASA
F
THV
L
L
L
K
S
P
Q
E
I
R
PT
I
D
TQ
KA
L
L
LV
R
F
P
AD
F
S
R
KL
D
TFQ
T
A
P
L
Q
L
-
-
I
L
DG
RNS
N
S
A
Q
I
AA
N
Y
L
Q
Q
I
VKNYQ
Q
ELLE
G
KPK
P
N
NSE
L
V
V
--
--
R
N
W
YNPNLD
YK
WF
V
VP
S
L
IA
M
I
--
T
T
I
GVM
I
V
T
S
LSV
A
RERE
Q
GT
L
DQ
LLV
S
P
L
T
TW
Q
I
F
I
GK
-
---
A
V
P
A
L
I
V
AT
F
QAT
I
V
LAIGIW
A
Y
QI
P
FA
GS
LA
LF
Y
F
TMV
I
Y
GLSL
V
G
F
GLLIS
S
LCS
T
Q
Q
QA
FI
GV
F
V
F
-
M
M
PA
IL
LSG
YVS
PVE
N
MP
---
V
W
L
Q
N
LTWIN
P
I
R
HF
TD
I
T
K
Q
I
YL
K
D
A
S
L
D
IVW
NS
L
W
PLL
V
I
TATTGSA
AY
AM
FR
RKV
M
fig|679207.4.peg.1448
Escherichia coli MS 107-1
MFHRL
WT
L
I
RKEL
Q
SLLR
E
P
QTRAILILPV
L
I
Q
V
I
L
F
P
F
AA
T
L
---------
E
V
T
NA
T
IAI
Y
D
E
D
N
GEH
S
VEL
T
QR
F
A
R
ASA
F
THV
L
L
L
K
S
P
Q
E
I
R
PT
I
D
TQ
KA
L
L
LV
R
F
P
AD
F
S
R
KL
D
TFQ
T
A
P
L
Q
L
-
-
I
L
DG
RNS
N
S
A
Q
I
AA
N
Y
L
Q
Q
I
VKNYQ
Q
ELLE
G
KPK
P
N
NSE
L
V
V
--
--
R
N
W
YNPNLD
YK
WF
V
VP
S
L
IA
M
I
--
T
T
I
GVM
I
V
T
S
LSV
A
RERE
Q
GT
L
DQ
LLV
S
P
L
T
TW
Q
I
F
I
GK
-
---
A
V
P
A
L
I
V
AT
F
QAT
I
V
LAIGIW
A
Y
QI
P
FA
GS
LA
LF
Y
F
TMV
I
Y
GLSL
V
G
F
GLLIS
S
LCS
T
Q
Q
QA
FI
GV
F
V
F
-
M
M
PA
IL
LSG
YVS
PVE
N
MP
---
V
W
L
Q
N
LTWIN
P
I
R
HF
TD
I
T
K
Q
I
YL
K
D
A
S
L
D
IVW
NS
L
W
PLL
V
I
TATTGSA
AY
AM
FR
RKV
M
fig|749537.3.peg.3536
Escherichia coli MS 115-1
MFHRL
WT
L
I
RKEL
Q
SLLR
E
P
QTRAILILPV
L
I
Q
V
I
L
F
P
F
AA
T
L
---------
E
V
T
NA
T
IAI
Y
D
E
D
N
GEH
S
VEL
T
QR
F
A
R
ASA
F
THV
L
L
L
K
S
P
Q
E
I
R
PT
I
D
TQ
KA
L
L
LV
R
F
P
AD
F
S
R
KL
D
TFQ
T
A
P
L
Q
L
-
-
I
L
DG
RNS
N
S
A
Q
I
AA
N
Y
L
Q
Q
I
VKNYQ
Q
ELLE
G
KPK
P
N
NSE
L
V
V
--
--
R
N
W
YNPNLD
YK
WF
V
VP
S
L
IA
M
I
--
T
T
I
GVM
I
V
T
S
LSV
A
RERE
Q
GT
L
DQ
LLV
S
P
L
T
TW
Q
I
F
I
GK
-
---
A
V
P
A
L
I
V
AT
F
QAT
I
V
LAIGIW
A
Y
QI
P
FA
GS
LA
LF
Y
F
TMV
I
Y
GLSL
V
G
F
GLLIS
S
LCS
T
Q
Q
QA
FI
GV
F
V
F
-
M
M
PA
IL
LSG
YVS
PVE
N
MP
---
V
W
L
Q
N
LTWIN
P
I
R
HF
TD
I
T
K
Q
I
YL
K
D
A
S
L
D
IVW
NS
L
W
PLL
V
I
TATTGSA
AY
AM
FR
RKV
M
fig|749538.3.peg.740
Escherichia coli MS 116-1
MFHRL
WT
L
I
RKEL
Q
SLLR
E
P
QTRAILILPV
L
I
Q
V
I
L
F
P
F
AA
T
L
---------
E
V
T
NA
T
IAI
Y
D
E
D
N
GEH
S
VEL
T
QR
F
A
R
ASA
F
THV
L
L
L
K
S
P
Q
E
I
R
PT
I
D
TQ
KA
L
L
LV
R
F
P
AD
F
S
R
KL
D
TFQ
T
A
P
L
Q
L
-
-
I
L
DG
RNS
N
S
A
Q
I
AA
N
Y
L
Q
Q
I
VKNYQ
Q
ELLE
G
KPK
P
N
NSE
L
V
V
--
--
R
N
W
YNPNLD
YK
WF
V
VP
S
L
IA
M
I
--
T
T
I
GVM
I
V
T
S
LSV
A
RERE
Q
GT
L
DQ
LLV
S
P
L
T
TW
Q
I
F
I
GK
-
---
A
V
P
A
L
I
V
AT
F
QAT
I
V
LAIGIW
A
Y
QI
P
FA
GS
LA
LF
Y
F
TMV
I
Y
GLSL
V
G
F
GLLIS
S
LCS
T
Q
Q
QA
FI
GV
F
V
F
-
M
M
PA
IL
LSG
YVS
PVE
N
MP
---
V
W
L
Q
N
LTWIN
P
I
R
HF
TD
I
T
K
Q
I
YL
K
D
A
S
L
D
IVW
NS
L
W
PLL
V
I
TATTGSA
AY
AM
FR
RKV
M
fig|679206.4.peg.2696
Escherichia coli MS 119-7
MFHRL
WT
L
I
RKEL
Q
SLLR
E
P
QTRAILILPV
L
I
Q
V
I
L
F
P
F
AA
T
L
---------
E
V
T
NA
T
IAI
Y
D
E
D
N
GEH
S
VEL
T
QR
F
A
R
ASA
F
THV
L
L
L
K
S
P
Q
E
I
R
PT
I
D
TQ
KA
L
L
LV
R
F
P
AD
F
S
R
KL
D
TFQ
T
A
P
L
Q
L
-
-
I
L
DG
RNS
N
S
A
Q
I
AA
N
Y
L
Q
Q
I
VKNYQ
Q
ELLE
G
KPK
P
N
NSE
L
V
V
--
--
R
N
W
YNPNLD
YK
WF
V
VP
S
L
IA
M
I
--
T
T
I
GVM
I
V
T
S
LSV
A
RERE
Q
GT
L
DQ
LLV
S
P
L
T
TW
Q
I
F
I
GK
-
---
A
V
P
A
L
I
V
AT
F
QAT
I
V
LAIGIW
A
Y
QI
P
FA
GS
LA
LF
Y
F
TMV
I
Y
GLSL
V
G
F
GLLIS
S
LCS
T
Q
Q
QA
FI
GV
F
V
F
-
M
M
PA
IL
LSG
YVS
PVE
N
MP
---
V
W
L
Q
N
LTWIN
P
I
R
HF
TD
I
T
K
Q
I
YL
K
D
A
S
L
D
IVW
NS
L
W
PLL
V
I
TATTGSA
AY
AM
FR
RKV
M
fig|679205.4.peg.5287
Escherichia coli MS 124-1
MFHRL
WT
L
I
RKEL
Q
SLLR
E
P
QTRAILILPV
L
I
Q
V
I
L
F
P
F
AA
T
L
---------
E
V
T
NA
T
IAI
Y
D
E
D
N
GEH
S
VEL
T
QR
F
A
R
ASA
F
THV
L
L
L
K
S
P
Q
E
I
R
PT
I
D
TQ
KA
L
L
LV
R
F
P
AD
F
S
R
KL
D
TFQ
T
A
P
L
Q
L
-
-
I
L
DG
RNS
N
S
A
Q
I
AA
N
Y
L
Q
Q
I
VKNYQ
Q
ELLE
G
KPK
P
N
NSE
L
V
V
--
--
R
N
W
YNPNLD
YK
WF
V
VP
S
L
IA
M
I
--
T
T
I
GVM
I
V
T
S
LSV
A
RERE
Q
GT
L
DQ
LLV
S
P
L
T
TW
Q
I
F
I
GK
-
---
A
V
P
A
L
I
V
AT
F
QAT
I
V
LAIGIW
A
Y
QI
P
FA
GS
LA
LF
Y
F
TMV
I
Y
GLSL
V
G
F
GLLIS
S
LCS
T
Q
Q
QA
FI
GV
F
V
F
-
M
M
PA
IL
LSG
YVS
PVE
N
MP
---
V
W
L
Q
N
LTWIN
P
I
R
HF
TD
I
T
K
Q
I
YL
K
D
A
S
L
D
IVW
NS
L
W
PLL
V
I
TATTGSA
AY
AM
FR
RKV
M
fig|679204.3.peg.5002
Escherichia coli MS 145-7
MFHRL
WT
L
I
RKEL
Q
SLLR
E
P
QTRAILILPV
L
I
Q
V
I
L
F
P
F
AA
T
L
---------
E
V
T
NA
T
IAI
Y
D
E
D
N
GEH
S
VEL
T
QR
F
A
R
ASA
F
THV
L
L
L
K
S
P
Q
E
I
R
PT
I
D
TQ
KA
L
L
LV
R
F
P
AD
F
S
R
KL
D
TFQ
T
A
P
L
Q
L
-
-
I
L
DG
RNS
N
S
A
Q
I
AA
N
Y
L
Q
Q
I
VKNYQ
Q
ELLE
G
KPK
P
N
NSE
L
V
V
--
--
R
N
W
YNPNLD
YK
WF
V
VP
S
L
IA
M
I
--
T
T
I
GVM
I
V
T
S
LSV
A
RERE
Q
GT
L
DQ
LLV
S
P
L
T
TW
Q
I
F
I
GK
-
---
A
V
P
A
L
I
V
AT
F
QAT
I
V
LAIGIW
A
Y
QI
P
FA
GS
LA
LF
Y
F
TMV
I
Y
GLSL
V
G
F
GLLIS
S
LCS
T
Q
Q
QA
FI
GV
F
V
F
-
M
M
PA
IL
LSG
YVS
PVE
N
MP
---
V
W
L
Q
N
LTWIN
P
I
R
HF
TD
I
T
K
Q
I
YL
K
D
A
S
L
D
IVW
NS
L
W
PLL
V
I
TATTGSA
AY
AM
FR
RKV
M
fig|749540.3.peg.2729
Escherichia coli MS 146-1
MFHRL
WT
L
I
RKEL
Q
SLLR
E
P
QTRAILILPV
L
I
Q
V
I
L
F
P
F
AA
T
L
---------
E
V
T
NA
T
IAI
Y
D
E
D
N
GEH
S
VEL
T
QR
F
A
R
ASA
F
THV
L
L
L
K
S
P
Q
E
I
R
PT
I
D
TQ
KA
L
L
LV
R
F
P
AD
F
S
R
KL
D
TFQ
T
A
P
L
Q
L
-
-
I
L
DG
RNS
N
S
A
Q
I
AA
N
Y
L
Q
Q
I
VKNYQ
Q
ELLE
G
KPK
P
N
NSE
L
V
V
--
--
R
N
W
YNPNLD
YK
WF
V
VP
S
L
IA
M
I
--
T
T
I
GVM
I
V
T
S
LSV
A
RERE
Q
GT
L
DQ
LLV
S
P
L
T
TW
Q
I
F
I
GK
-
---
A
V
P
A
L
I
V
AT
F
QAT
I
V
LAIGIW
A
Y
QI
P
FA
GS
LA
LF
Y
F
TMV
I
Y
GLSL
V
G
F
GLLIS
S
LCS
T
Q
Q
QA
FI
GV
F
V
F
-
M
M
PA
IL
LSG
YVS
PVE
N
MP
---
V
W
L
Q
N
LTWIN
P
I
R
HF
TD
I
T
K
Q
I
YL
K
D
A
S
L
D
IVW
NS
L
W
PLL
V
I
TATTGSA
AY
AM
FR
RKV
M
fig|749544.3.peg.3342
Escherichia coli MS 175-1
MFHRL
WT
L
I
RKEL
Q
SLLR
E
P
QTRAILILPV
L
I
Q
V
I
L
F
P
F
AA
T
L
---------
E
V
T
NA
T
IAI
Y
D
E
D
N
GEH
S
VEL
T
QR
F
A
R
ASA
F
THV
L
L
L
K
S
P
Q
E
I
R
PT
I
D
TQ
KA
L
L
LV
R
F
P
AD
F
S
R
KL
D
TFQ
T
A
P
L
Q
L
-
-
I
L
DG
RNS
N
S
A
Q
I
AA
N
Y
L
Q
Q
I
VKNYQ
Q
ELLE
G
KPK
P
N
NSE
L
V
V
--
--
R
N
W
YNPNLD
YK
WF
V
VP
S
L
IA
M
I
--
T
T
I
GVM
I
V
T
S
LSV
A
RERE
Q
GT
L
DQ
LLV
S
P
L
T
TW
Q
I
F
I
GK
-
---
A
V
P
A
L
I
V
AT
F
QAT
I
V
LAIGIW
A
Y
QI
P
FA
GS
LA
LF
Y
F
TMV
I
Y
GLSL
V
G
F
GLLIS
S
LCS
T
Q
Q
QA
FI
GV
F
V
F
-
M
M
PA
IL
LSG
YVS
PVE
N
MP
---
V
W
L
Q
N
LTWIN
P
I
R
HF
TD
I
T
K
Q
I
YL
K
D
A
S
L
D
IVW
NS
L
W
PLL
V
I
TATTGSA
AY
AM
FR
RKV
M
fig|749545.3.peg.985
Escherichia coli MS 182-1
MFHRL
WT
L
I
RKEL
Q
SLLR
E
P
QTRAILILPV
L
I
Q
V
I
L
F
P
F
AA
T
L
---------
E
V
T
NA
T
IAI
Y
D
E
D
N
GEH
S
VEL
T
QR
F
A
R
ASA
F
THV
L
L
L
K
S
P
Q
E
I
R
PT
I
D
TQ
KA
L
L
LV
R
F
P
AD
F
S
R
KL
D
TFQ
T
A
P
L
Q
L
-
-
I
L
DG
RNS
N
S
A
Q
I
AA
N
Y
L
Q
Q
I
VKNYQ
Q
ELLE
G
KPK
P
N
NSE
L
V
V
--
--
R
N
W
YNPNLD
YK
WF
V
VP
S
L
IA
M
I
--
T
T
I
GVM
I
V
T
S
LSV
A
RERE
Q
GT
L
DQ
LLV
S
P
L
T
TW
Q
I
F
I
GK
-
---
A
V
P
A
L
I
V
AT
F
QAT
I
V
LAIGIW
A
Y
QI
P
FA
GS
LA
LF
Y
F
TMV
I
Y
GLSL
V
G
F
GLLIS
S
LCS
T
Q
Q
QA
FI
GV
F
V
F
-
M
M
PA
IL
LSG
YVS
PVE
N
MP
---
V
W
L
Q
N
LTWIN
P
I
R
HF
TD
I
T
K
Q
I
YL
K
D
A
S
L
D
IVW
NS
L
W
PLL
V
I
TATTGSA
AY
AM
FR
RKV
M
fig|749547.3.peg.1660
Escherichia coli MS 187-1
MFHRL
WT
L
I
RKEL
Q
SLLR
E
P
QTRAILILPV
L
I
Q
V
I
L
F
P
F
AA
T
L
---------
E
V
T
NA
T
IAI
Y
D
E
D
N
GEH
S
VEL
T
QR
F
A
R
ASA
F
THV
L
L
L
K
S
P
Q
E
I
R
PT
I
D
TQ
KA
L
L
LV
R
F
P
AD
F
S
R
KL
D
TFQ
T
A
P
L
Q
L
-
-
I
L
DG
RNS
N
S
A
Q
I
AA
N
Y
L
Q
Q
I
VKNYQ
Q
ELLE
G
KPK
P
N
NSE
L
V
V
--
--
R
N
W
YNPNLD
YK
WF
V
VP
S
L
IA
M
I
--
T
T
I
GVM
I
V
T
S
LSV
A
RERE
Q
GT
L
DQ
LLV
S
P
L
T
TW
Q
I
F
I
GK
-
---
A
V
P
A
L
I
V
AT
F
QAT
I
V
LAIGIW
A
Y
QI
P
FA
GS
LA
LF
Y
F
TMV
I
Y
GLSL
V
G
F
GLLIS
S
LCS
T
Q
Q
QA
FI
GV
F
V
F
-
M
M
PA
IL
LSG
YVS
PVE
N
MP
---
V
W
L
Q
N
LTWIN
P
I
R
HF
TD
I
T
K
Q
I
YL
K
D
A
S
L
D
IVW
NS
L
W
PLL
V
I
TATTGSA
AY
AM
FR
RKV
M
fig|749548.3.peg.2298
Escherichia coli MS 196-1
MFHRL
WT
L
I
RKEL
Q
SLLR
E
P
QTRAILILPV
L
I
Q
V
I
L
F
P
F
AA
T
L
---------
E
V
T
NA
T
IAI
Y
D
E
D
N
GEH
S
VEL
T
QR
F
A
R
ASA
F
THV
L
L
L
K
S
P
Q
E
I
R
PT
I
D
TQ
KA
L
L
LV
R
F
P
AD
F
S
R
KL
D
TFQ
T
A
P
L
Q
L
-
-
I
L
DG
RNS
N
S
A
Q
I
AA
N
Y
L
Q
Q
I
VKNYQ
Q
ELLE
G
KPK
P
N
NSE
L
V
V
--
--
R
N
W
YNPNLD
YK
WF
V
VP
S
L
IA
M
I
--
T
T
I
GVM
I
V
T
S
LSV
A
RERE
Q
GT
L
DQ
LLV
S
P
L
T
TW
Q
I
F
I
GK
-
---
A
V
P
A
L
I
V
AT
F
QAT
I
V
LAIGIW
A
Y
QI
P
FA
GS
LA
LF
Y
F
TMV
I
Y
GLSL
V
G
F
GLLIS
S
LCS
T
Q
Q
QA
FI
GV
F
V
F
-
M
M
PA
IL
LSG
YVS
PVE
N
MP
---
V
W
L
Q
N
LTWIN
P
I
R
HF
TD
I
T
K
Q
I
YL
K
D
A
S
L
D
IVW
NS
L
W
PLL
V
I
TATTGSA
AY
AM
FR
RKV
M
fig|749549.3.peg.2307
Escherichia coli MS 198-1
MFHRL
WT
L
I
RKEL
Q
SLLR
E
P
QTRAILILPV
L
I
Q
V
I
L
F
P
F
AA
T
L
---------
E
V
T
NA
T
IAI
Y
D
E
D
N
GEH
S
VEL
T
QR
F
A
R
ASA
F
THV
L
L
L
K
S
P
Q
E
I
R
PT
I
D
TQ
KA
L
L
LV
R
F
P
AD
F
S
R
KL
D
TFQ
T
A
P
L
Q
L
-
-
I
L
DG
RNS
N
S
A
Q
I
AA
N
Y
L
Q
Q
I
VKNYQ
Q
ELLE
G
KPK
P
N
NSE
L
V
V
--
--
R
N
W
YNPNLD
YK
WF
V
VP
S
L
IA
M
I
--
T
T
I
GVM
I
V
T
S
LSV
A
RERE
Q
GT
L
DQ
LLV
S
P
L
T
TW
Q
I
F
I
GK
-
---
A
V
P
A
L
I
V
AT
F
QAT
I
V
LAIGIW
A
Y
QI
P
FA
GS
LA
LF
Y
F
TMV
I
Y
GLSL
V
G
F
GLLIS
S
LCS
T
Q
Q
QA
FI
GV
F
V
F
-
M
M
PA
IL
LSG
YVS
PVE
N
MP
---
V
W
L
Q
N
LTWIN
P
I
R
HF
TD
I
T
K
Q
I
YL
K
D
A
S
L
D
IVW
NS
L
W
PLL
V
I
TATTGSA
AY
AM
FR
RKV
M
fig|749550.3.peg.3778
Escherichia coli MS 200-1
MFHRL
WT
L
I
RKEL
Q
SLLR
E
P
QTRAILILPV
L
I
Q
V
I
L
F
P
F
AA
T
L
---------
E
V
T
NA
T
IAI
Y
D
E
D
N
GEH
S
VEL
T
QR
F
A
R
ASA
F
THV
L
L
L
K
S
P
Q
E
I
R
PT
I
D
TQ
KA
L
L
LV
R
F
P
AD
F
S
R
KL
D
TFQ
T
A
P
L
Q
L
-
-
I
L
DG
RNS
N
S
A
Q
I
AA
N
Y
L
Q
Q
I
VKNYQ
Q
ELLE
G
KPK
P
N
NSE
L
V
V
--
--
R
N
W
YNPNLD
YK
WF
V
VP
S
L
IA
M
I
--
T
T
I
GVM
I
V
T
S
LSV
A
RERE
Q
GT
L
DQ
LLV
S
P
L
T
TW
Q
I
F
I
GK
-
---
A
V
P
A
L
I
V
AT
F
QAT
I
V
LAIGIW
A
Y
QI
P
FA
GS
LA
LF
Y
F
TMV
I
Y
GLSL
V
G
F
GLLIS
S
LCS
T
Q
Q
QA
FI
GV
F
V
F
-
M
M
PA
IL
LSG
YVS
PVE
N
MP
---
V
W
L
Q
N
LTWIN
P
I
R
HF
TD
I
T
K
Q
I
YL
K
D
A
S
L
D
IVW
NS
L
W
PLL
V
I
TATTGSA
AY
AM
FR
RKV
M
fig|749527.3.peg.4361
Escherichia coli MS 21-1
MFHRL
WT
L
I
RKEL
Q
SLLR
E
P
QTRAILILPV
L
I
Q
V
I
L
F
P
F
AA
T
L
---------
E
V
T
NA
T
IAI
Y
D
E
D
N
GEH
S
VEL
T
QR
F
A
R
ASA
F
THV
L
L
L
K
S
P
Q
E
I
R
PT
I
D
TQ
KA
L
L
LV
R
F
P
AD
F
S
R
KL
D
TFQ
T
A
P
L
Q
L
-
-
I
L
DG
RNS
N
S
A
Q
I
AA
N
Y
L
Q
Q
I
VKNYQ
Q
ELLE
G
KPK
P
N
NSE
L
V
V
--
--
R
N
W
YNPNLD
YK
WF
V
VP
S
L
IA
M
I
--
T
T
I
GVM
I
V
T
S
LSV
A
RERE
Q
GT
L
DQ
LLV
S
P
L
T
TW
Q
I
F
I
GK
-
---
A
V
P
A
L
I
V
AT
F
QAT
I
V
LAIGIW
A
Y
QI
P
FA
GS
LA
LF
Y
F
TMV
I
Y
GLSL
V
G
F
GLLIS
S
LCS
T
Q
Q
QA
FI
GV
F
V
F
-
M
M
PA
IL
LSG
YVS
PVE
N
MP
---
V
W
L
Q
N
LTWIN
P
I
R
HF
TD
I
T
K
Q
I
YL
K
D
A
S
L
D
IVW
NS
L
W
PLL
V
I
TATTGSA
AY
AM
FR
RKV
M
fig|749531.3.peg.1765
Escherichia coli MS 69-1
MFHRL
WT
L
I
RKEL
Q
SLLR
E
P
QTRAILILPV
L
I
Q
V
I
L
F
P
F
AA
T
L
---------
E
V
T
NA
T
IAI
Y
D
E
D
N
GEH
S
VEL
T
QR
F
A
R
ASA
F
THV
L
L
L
K
S
P
Q
E
I
R
PT
I
D
TQ
KA
L
L
LV
R
F
P
AD
F
S
R
KL
D
TFQ
T
A
P
L
Q
L
-
-
I
L
DG
RNS
N
S
A
Q
I
AA
N
Y
L
Q
Q
I
VKNYQ
Q
ELLE
G
KPK
P
N
NSE
L
V
V
--
--
R
N
W
YNPNLD
YK
WF
V
VP
S
L
IA
M
I
--
T
T
I
GVM
I
V
T
S
LSV
A
RERE
Q
GT
L
DQ
LLV
S
P
L
T
TW
Q
I
F
I
GK
-
---
A
V
P
A
L
I
V
AT
F
QAT
I
V
LAIGIW
A
Y
QI
P
FA
GS
LA
LF
Y
F
TMV
I
Y
GLSL
V
G
F
GLLIS
S
LCS
T
Q
Q
QA
FI
GV
F
V
F
-
M
M
PA
IL
LSG
YVS
PVE
N
MP
---
V
W
L
Q
N
LTWIN
P
I
R
HF
TD
I
T
K
Q
I
YL
K
D
A
S
L
D
IVW
NS
L
W
PLL
V
I
TATTGSA
AY
AM
FR
RKV
M
fig|749532.3.peg.2664
Escherichia coli MS 78-1
MFHRL
WT
L
I
RKEL
Q
SLLR
E
P
QTRAILILPV
L
I
Q
V
I
L
F
P
F
AA
T
L
---------
E
V
T
NA
T
IAI
Y
D
E
D
N
GEH
S
VEL
T
QR
F
A
R
ASA
F
THV
L
L
L
K
S
P
Q
E
I
R
PT
I
D
TQ
KA
L
L
LV
R
F
P
AD
F
S
R
KL
D
TFQ
T
A
P
L
Q
L
-
-
I
L
DG
RNS
N
S
A
Q
I
AA
N
Y
L
Q
Q
I
VKNYQ
Q
ELLE
G
KPK
P
N
NSE
L
V
V
--
--
R
N
W
YNPNLD
YK
WF
V
VP
S
L
IA
M
I
--
T
T
I
GVM
I
V
T
S
LSV
A
RERE
Q
GT
L
DQ
LLV
S
P
L
T
TW
Q
I
F
I
GK
-
---
A
V
P
A
L
I
V
AT
F
QAT
I
V
LAIGIW
A
Y
QI
P
FA
GS
LA
LF
Y
F
TMV
I
Y
GLSL
V
G
F
GLLIS
S
LCS
T
Q
Q
QA
FI
GV
F
V
F
-
M
M
PA
IL
LSG
YVS
PVE
N
MP
---
V
W
L
Q
N
LTWIN
P
I
R
HF
TD
I
T
K
Q
I
YL
K
D
A
S
L
D
IVW
NS
L
W
PLL
V
I
TATTGSA
AY
AM
FR
RKV
M
fig|749533.3.peg.4803
Escherichia coli MS 84-1
MFHRL
WT
L
I
RKEL
Q
SLLR
E
P
QTRAILILPV
L
I
Q
V
I
L
F
P
F
AA
T
L
---------
E
V
T
NA
T
IAI
Y
D
E
D
N
GEH
S
VEL
T
QR
F
A
R
ASA
F
THV
L
L
L
K
S
P
Q
E
I
R
PT
I
D
TQ
KA
L
L
LV
R
F
P
AD
F
S
R
KL
D
TFQ
T
A
P
L
Q
L
-
-
I
L
DG
RNS
N
S
A
Q
I
AA
N
Y
L
Q
Q
I
VKNYQ
Q
ELLE
G
KPK
P
N
NSE
L
V
V
--
--
R
N
W
YNPNLD
YK
WF
V
VP
S
L
IA
M
I
--
T
T
I
GVM
I
V
T
S
LSV
A
RERE
Q
GT
L
DQ
LLV
S
P
L
T
TW
Q
I
F
I
GK
-
---
A
V
P
A
L
I
V
AT
F
QAT
I
V
LAIGIW
A
Y
QI
P
FA
GS
LA
LF
Y
F
TMV
I
Y
GLSL
V
G
F
GLLIS
S
LCS
T
Q
Q
QA
FI
GV
F
V
F
-
M
M
PA
IL
LSG
YVS
PVE
N
MP
---
V
W
L
Q
N
LTWIN
P
I
R
HF
TD
I
T
K
Q
I
YL
K
D
A
S
L
D
IVW
NS
L
W
PLL
V
I
TATTGSA
AY
AM
FR
RKV
M
fig|753642.3.peg.874
Escherichia coli NC101
MFHRL
WT
L
I
RKEL
Q
SLLR
E
P
QTRAILILPV
L
I
Q
V
I
L
F
P
F
AA
T
L
---------
E
V
T
NA
T
IAI
Y
D
E
D
N
GEH
S
VEL
T
QR
F
A
R
ASA
F
THV
L
L
L
K
S
P
Q
E
I
R
PT
I
D
TQ
KA
L
L
LV
R
F
P
AD
F
S
R
KL
D
TFQ
T
A
P
L
Q
L
-
-
I
L
DG
RNS
N
S
A
Q
I
AA
N
Y
L
Q
Q
I
VKNYQ
Q
ELLE
G
KPK
P
N
NSE
L
V
V
--
--
R
N
W
YNPNLD
YK
WF
V
VP
S
L
IA
M
I
--
T
T
I
GVM
I
V
T
S
LSV
A
RERE
Q
GT
L
DQ
LLV
S
P
L
T
TW
Q
I
F
I
GK
-
---
A
V
P
A
L
I
V
AT
F
QAT
I
V
LAIGIW
A
Y
QI
P
FA
GS
LA
LF
Y
F
TMV
I
Y
GLSL
V
G
F
GLLIS
S
LCS
T
Q
Q
QA
FI
GV
F
V
F
-
M
M
PA
IL
LSG
YVS
PVE
N
MP
---
V
W
L
Q
N
LTWIN
P
I
R
HF
TD
I
T
K
Q
I
YL
K
D
A
S
L
D
IVW
NS
L
W
PLL
V
I
TATTGSA
AY
AM
FR
RKV
M
fig|585395.4.peg.873
Escherichia coli O103:H2 str. 12009
MFHRL
WT
L
I
RKEL
Q
SLLR
E
P
QTRAILILPV
L
I
Q
V
I
L
F
P
F
AA
T
L
---------
E
V
T
NA
T
IAI
Y
D
E
D
N
GEH
S
VEL
T
QR
F
A
R
ASA
F
THV
L
L
L
K
S
P
Q
E
I
R
PT
I
D
TQ
KA
L
L
LV
R
F
P
AD
F
S
R
KL
D
TFQ
T
A
P
L
Q
L
-
-
I
L
DG
RNS
N
S
A
Q
I
AA
N
Y
L
Q
Q
I
VKNYQ
Q
ELLE
G
KPK
P
N
NSE
L
V
V
--
--
R
N
W
YNPNLD
YK
WF
V
VP
S
L
IA
M
I
--
T
T
I
GVM
I
V
T
S
LSV
A
RERE
Q
GT
L
DQ
LLV
S
P
L
T
TW
Q
I
F
I
GK
-
---
A
V
P
A
L
I
V
AT
F
QAT
I
V
LAIGIW
A
Y
QI
P
FA
GS
LA
LF
Y
F
TMV
I
Y
GLSL
V
G
F
GLLIS
S
LCS
T
Q
Q
QA
FI
GV
F
V
F
-
M
M
PA
IL
LSG
YVS
PVE
N
MP
---
V
W
L
Q
N
LTWIN
P
I
R
HF
TD
I
T
K
Q
I
YL
K
D
A
S
L
D
IVW
NS
L
W
PLL
V
I
TATTGSA
AY
AM
FR
RKV
M
fig|585396.4.peg.887
Escherichia coli O111:H- str. 11128
MFHRL
WT
L
I
RKEL
Q
SLLR
E
P
QTRAILILPV
L
I
Q
V
I
L
F
P
F
AA
T
L
---------
E
V
T
NA
T
IAI
Y
D
E
D
N
GEH
S
VEL
T
QR
F
A
R
ASA
F
THV
L
L
L
K
S
P
Q
E
I
R
PT
I
D
TQ
KA
L
L
LV
R
F
P
AD
F
S
R
KL
D
TFQ
T
A
P
L
Q
L
-
-
I
L
DG
RNS
N
S
A
Q
I
AA
N
Y
L
Q
Q
I
VKNYQ
Q
ELLE
G
KPK
P
N
NSE
L
V
V
--
--
R
N
W
YNPNLD
YK
WF
V
VP
S
L
IA
M
I
--
T
T
I
GVM
I
V
T
S
LSV
A
RERE
Q
GT
L
DQ
LLV
S
P
L
T
TW
Q
I
F
I
GK
-
---
A
V
P
A
L
I
V
AT
F
QAT
I
V
LAIGIW
A
Y
QI
P
FA
GS
LA
LF
Y
F
TMV
I
Y
GLSL
V
G
F
GLLIS
S
LCS
T
Q
Q
QA
FI
GV
F
V
F
-
M
M
PA
IL
LSG
YVS
PVE
N
MP
---
V
W
L
Q
N
LTWIN
P
I
R
HF
TD
I
T
K
Q
I
YL
K
D
A
S
L
D
IVW
NS
L
W
PLL
V
I
TATTGSA
AY
AM
FR
RKV
M
fig|83334.1.peg.940
Escherichia coli O157:H7
MFHRL
WT
L
I
RKEL
Q
SLLR
E
P
QTRAILILPV
L
I
Q
V
I
L
F
P
F
AA
T
L
---------
E
V
T
NA
T
IAI
Y
D
E
D
N
GEH
S
VEL
T
QR
F
A
R
ASA
F
THV
L
L
L
K
S
P
Q
E
I
R
PT
I
D
TQ
KA
L
L
LV
R
F
P
AD
F
S
R
KL
D
TFQ
T
A
P
L
Q
L
-
-
I
L
DG
RNS
N
S
A
Q
I
AA
N
Y
L
Q
Q
I
VKNYQ
Q
ELLE
G
KPK
P
N
NSE
L
V
V
--
--
R
N
W
YNPNLD
YK
WF
V
VP
S
L
IA
M
I
--
T
T
I
GVM
I
V
T
S
LSV
A
RERE
Q
GT
L
DQ
LLV
S
P
L
T
TW
Q
I
F
I
GK
-
---
A
V
P
A
L
I
V
AT
F
QAT
I
V
LAIGIW
A
Y
QI
P
FA
GS
LA
LF
Y
F
TMV
I
Y
GLSL
V
G
F
GLLIS
S
LCS
T
Q
Q
QA
FI
GV
F
V
F
-
M
M
PA
IL
LSG
YVS
PVE
N
MP
---
V
W
L
Q
N
LTWIN
P
I
R
HF
TD
I
T
K
Q
I
YL
K
D
A
S
L
D
IVW
NS
L
W
PLL
V
I
TATTGSA
AY
AM
FR
RKV
M
fig|444454.5.peg.5361
Escherichia coli O157:H7 str. EC4024
MFHRL
WT
L
I
RKEL
Q
SLLR
E
P
QTRAILILPV
L
I
Q
V
I
L
F
P
F
AA
T
L
---------
E
V
T
NA
T
IAI
Y
D
E
D
N
GEH
S
VEL
T
QR
F
A
R
ASA
F
THV
L
L
L
K
S
P
Q
E
I
R
PT
I
D
TQ
KA
L
L
LV
R
F
P
AD
F
S
R
KL
D
TFQ
T
A
P
L
Q
L
-
-
I
L
DG
RNS
N
S
A
Q
I
AA
N
Y
L
Q
Q
I
VKNYQ
Q
ELLE
G
KPK
P
N
NSE
L
V
V
--
--
R
N
W
YNPNLD
YK
WF
V
VP
S
L
IA
M
I
--
T
T
I
GVM
I
V
T
S
LSV
A
RERE
Q
GT
L
DQ
LLV
S
P
L
T
TW
Q
I
F
I
GK
-
---
A
V
P
A
L
I
V
AT
F
QAT
I
V
LAIGIW
A
Y
QI
P
FA
GS
LA
LF
Y
F
TMV
I
Y
GLSL
V
G
F
GLLIS
S
LCS
T
Q
Q
QA
FI
GV
F
V
F
-
M
M
PA
IL
LSG
YVS
PVE
N
MP
---
V
W
L
Q
N
LTWIN
P
I
R
HF
TD
I
T
K
Q
I
YL
K
D
A
S
L
D
IVW
NS
L
W
PLL
V
I
TATTGSA
AY
AM
FR
RKV
M
fig|444449.5.peg.4294
Escherichia coli O157:H7 str. EC4042
MFHRL
WT
L
I
RKEL
Q
SLLR
E
P
QTRAILILPV
L
I
Q
V
I
L
F
P
F
AA
T
L
---------
E
V
T
NA
T
IAI
Y
D
E
D
N
GEH
S
VEL
T
QR
F
A
R
ASA
F
THV
L
L
L
K
S
P
Q
E
I
R
PT
I
D
TQ
KA
L
L
LV
R
F
P
AD
F
S
R
KL
D
TFQ
T
A
P
L
Q
L
-
-
I
L
DG
RNS
N
S
A
Q
I
AA
N
Y
L
Q
Q
I
VKNYQ
Q
ELLE
G
KPK
P
N
NSE
L
V
V
--
--
R
N
W
YNPNLD
YK
WF
V
VP
S
L
IA
M
I
--
T
T
I
GVM
I
V
T
S
LSV
A
RERE
Q
GT
L
DQ
LLV
S
P
L
T
TW
Q
I
F
I
GK
-
---
A
V
P
A
L
I
V
AT
F
QAT
I
V
LAIGIW
A
Y
QI
P
FA
GS
LA
LF
Y
F
TMV
I
Y
GLSL
V
G
F
GLLIS
S
LCS
T
Q
Q
QA
FI
GV
F
V
F
-
M
M
PA
IL
LSG
YVS
PVE
N
MP
---
V
W
L
Q
N
LTWIN
P
I
R
HF
TD
I
T
K
Q
I
YL
K
D
A
S
L
D
IVW
NS
L
W
PLL
V
I
TATTGSA
AY
AM
FR
RKV
M
fig|444448.5.peg.3571
Escherichia coli O157:H7 str. EC4045
MFHRL
WT
L
I
RKEL
Q
SLLR
E
P
QTRAILILPV
L
I
Q
V
I
L
F
P
F
AA
T
L
---------
E
V
T
NA
T
IAI
Y
D
E
D
N
GEH
S
VEL
T
QR
F
A
R
ASA
F
THV
L
L
L
K
S
P
Q
E
I
R
PT
I
D
TQ
KA
L
L
LV
R
F
P
AD
F
S
R
KL
D
TFQ
T
A
P
L
Q
L
-
-
I
L
DG
RNS
N
S
A
Q
I
AA
N
Y
L
Q
Q
I
VKNYQ
Q
ELLE
G
KPK
P
N
NSE
L
V
V
--
--
R
N
W
YNPNLD
YK
WF
V
VP
S
L
IA
M
I
--
T
T
I
GVM
I
V
T
S
LSV
A
RERE
Q
GT
L
DQ
LLV
S
P
L
T
TW
Q
I
F
I
GK
-
---
A
V
P
A
L
I
V
AT
F
QAT
I
V
LAIGIW
A
Y
QI
P
FA
GS
LA
LF
Y
F
TMV
I
Y
GLSL
V
G
F
GLLIS
S
LCS
T
Q
Q
QA
FI
GV
F
V
F
-
M
M
PA
IL
LSG
YVS
PVE
N
MP
---
V
W
L
Q
N
LTWIN
P
I
R
HF
TD
I
T
K
Q
I
YL
K
D
A
S
L
D
IVW
NS
L
W
PLL
V
I
TATTGSA
AY
AM
FR
RKV
M
fig|444453.5.peg.913
Escherichia coli O157:H7 str. EC4076
MFHRL
WT
L
I
RKEL
Q
SLLR
E
P
QTRAILILPV
L
I
Q
V
I
L
F
P
F
AA
T
L
---------
E
V
T
NA
T
IAI
Y
D
E
D
N
GEH
S
VEL
T
QR
F
A
R
ASA
F
THV
L
L
L
K
S
P
Q
E
I
R
PT
I
D
TQ
KA
L
L
LV
R
F
P
AD
F
S
R
KL
D
TFQ
T
A
P
L
Q
L
-
-
I
L
DG
RNS
N
S
A
Q
I
AA
N
Y
L
Q
Q
I
VKNYQ
Q
ELLE
G
KPK
P
N
NSE
L
V
V
--
--
R
N
W
YNPNLD
YK
WF
V
VP
S
L
IA
M
I
--
T
T
I
GVM
I
V
T
S
LSV
A
RERE
Q
GT
L
DQ
LLV
S
P
L
T
TW
Q
I
F
I
GK
-
---
A
V
P
A
L
I
V
AT
F
QAT
I
V
LAIGIW
A
Y
QI
P
FA
GS
LA
LF
Y
F
TMV
I
Y
GLSL
V
G
F
GLLIS
S
LCS
T
Q
Q
QA
FI
GV
F
V
F
-
M
M
PA
IL
LSG
YVS
PVE
N
MP
---
V
W
L
Q
N
LTWIN
P
I
R
HF
TD
I
T
K
Q
I
YL
K
D
A
S
L
D
IVW
NS
L
W
PLL
V
I
TATTGSA
AY
AM
FR
RKV
M
fig|444452.5.peg.4893
Escherichia coli O157:H7 str. EC4113
MFHRL
WT
L
I
RKEL
Q
SLLR
E
P
QTRAILILPV
L
I
Q
V
I
L
F
P
F
AA
T
L
---------
E
V
T
NA
T
IAI
Y
D
E
D
N
GEH
S
VEL
T
QR
F
A
R
ASA
F
THV
L
L
L
K
S
P
Q
E
I
R
PT
I
D
TQ
KA
L
L
LV
R
F
P
AD
F
S
R
KL
D
TFQ
T
A
P
L
Q
L
-
-
I
L
DG
RNS
N
S
A
Q
I
AA
N
Y
L
Q
Q
I
VKNYQ
Q
ELLE
G
KPK
P
N
NSE
L
V
V
--
--
R
N
W
YNPNLD
YK
WF
V
VP
S
L
IA
M
I
--
T
T
I
GVM
I
V
T
S
LSV
A
RERE
Q
GT
L
DQ
LLV
S
P
L
T
TW
Q
I
F
I
GK
-
---
A
V
P
A
L
I
V
AT
F
QAT
I
V
LAIGIW
A
Y
QI
P
FA
GS
LA
LF
Y
F
TMV
I
Y
GLSL
V
G
F
GLLIS
S
LCS
T
Q
Q
QA
FI
GV
F
V
F
-
M
M
PA
IL
LSG
YVS
PVE
N
MP
---
V
W
L
Q
N
LTWIN
P
I
R
HF
TD
I
T
K
Q
I
YL
K
D
A
S
L
D
IVW
NS
L
W
PLL
V
I
TATTGSA
AY
AM
FR
RKV
M
fig|444450.8.peg.1028
Escherichia coli O157:H7 str. EC4115
MFHRL
WT
L
I
RKEL
Q
SLLR
E
P
QTRAILILPV
L
I
Q
V
I
L
F
P
F
AA
T
L
---------
E
V
T
NA
T
IAI
Y
D
E
D
N
GEH
S
VEL
T
QR
F
A
R
ASA
F
THV
L
L
L
K
S
P
Q
E
I
R
PT
I
D
TQ
KA
L
L
LV
R
F
P
AD
F
S
R
KL
D
TFQ
T
A
P
L
Q
L
-
-
I
L
DG
RNS
N
S
A
Q
I
AA
N
Y
L
Q
Q
I
VKNYQ
Q
ELLE
G
KPK
P
N
NSE
L
V
V
--
--
R
N
W
YNPNLD
YK
WF
V
VP
S
L
IA
M
I
--
T
T
I
GVM
I
V
T
S
LSV
A
RERE
Q
GT
L
DQ
LLV
S
P
L
T
TW
Q
I
F
I
GK
-
---
A
V
P
A
L
I
V
AT
F
QAT
I
V
LAIGIW
A
Y
QI
P
FA
GS
LA
LF
Y
F
TMV
I
Y
GLSL
V
G
F
GLLIS
S
LCS
T
Q
Q
QA
FI
GV
F
V
F
-
M
M
PA
IL
LSG
YVS
PVE
N
MP
---
V
W
L
Q
N
LTWIN
P
I
R
HF
TD
I
T
K
Q
I
YL
K
D
A
S
L
D
IVW
NS
L
W
PLL
V
I
TATTGSA
AY
AM
FR
RKV
M
fig|444451.5.peg.4695
Escherichia coli O157:H7 str. EC4196
MFHRL
WT
L
I
RKEL
Q
SLLR
E
P
QTRAILILPV
L
I
Q
V
I
L
F
P
F
AA
T
L
---------
E
V
T
NA
T
IAI
Y
D
E
D
N
GEH
S
VEL
T
QR
F
A
R
ASA
F
THV
L
L
L
K
S
P
Q
E
I
R
PT
I
D
TQ
KA
L
L
LV
R
F
P
AD
F
S
R
KL
D
TFQ
T
A
P
L
Q
L
-
-
I
L
DG
RNS
N
S
A
Q
I
AA
N
Y
L
Q
Q
I
VKNYQ
Q
ELLE
G
KPK
P
N
NSE
L
V
V
--
--
R
N
W
YNPNLD
YK
WF
V
VP
S
L
IA
M
I
--
T
T
I
GVM
I
V
T
S
LSV
A
RERE
Q
GT
L
DQ
LLV
S
P
L
T
TW
Q
I
F
I
GK
-
---
A
V
P
A
L
I
V
AT
F
QAT
I
V
LAIGIW
A
Y
QI
P
FA
GS
LA
LF
Y
F
TMV
I
Y
GLSL
V
G
F
GLLIS
S
LCS
T
Q
Q
QA
FI
GV
F
V
F
-
M
M
PA
IL
LSG
YVS
PVE
N
MP
---
V
W
L
Q
N
LTWIN
P
I
R
HF
TD
I
T
K
Q
I
YL
K
D
A
S
L
D
IVW
NS
L
W
PLL
V
I
TATTGSA
AY
AM
FR
RKV
M
fig|444447.5.peg.3762
Escherichia coli O157:H7 str. EC4206
MFHRL
WT
L
I
RKEL
Q
SLLR
E
P
QTRAILILPV
L
I
Q
V
I
L
F
P
F
AA
T
L
---------
E
V
T
NA
T
IAI
Y
D
E
D
N
GEH
S
VEL
T
QR
F
A
R
ASA
F
THV
L
L
L
K
S
P
Q
E
I
R
PT
I
D
TQ
KA
L
L
LV
R
F
P
AD
F
S
R
KL
D
TFQ
T
A
P
L
Q
L
-
-
I
L
DG
RNS
N
S
A
Q
I
AA
N
Y
L
Q
Q
I
VKNYQ
Q
ELLE
G
KPK
P
N
NSE
L
V
V
--
--
R
N
W
YNPNLD
YK
WF
V
VP
S
L
IA
M
I
--
T
T
I
GVM
I
V
T
S
LSV
A
RERE
Q
GT
L
DQ
LLV
S
P
L
T
TW
Q
I
F
I
GK
-
---
A
V
P
A
L
I
V
AT
F
QAT
I
V
LAIGIW
A
Y
QI
P
FA
GS
LA
LF
Y
F
TMV
I
Y
GLSL
V
G
F
GLLIS
S
LCS
T
Q
Q
QA
FI
GV
F
V
F
-
M
M
PA
IL
LSG
YVS
PVE
N
MP
---
V
W
L
Q
N
LTWIN
P
I
R
HF
TD
I
T
K
Q
I
YL
K
D
A
S
L
D
IVW
NS
L
W
PLL
V
I
TATTGSA
AY
AM
FR
RKV
M
fig|478004.5.peg.3289
Escherichia coli O157:H7 str. EC4401
MFHRL
WT
L
I
RKEL
Q
SLLR
E
P
QTRAILILPV
L
I
Q
V
I
L
F
P
F
AA
T
L
---------
E
V
T
NA
T
IAI
Y
D
E
D
N
GEH
S
VEL
T
QR
F
A
R
ASA
F
THV
L
L
L
K
S
P
Q
E
I
R
PT
I
D
TQ
KA
L
L
LV
R
F
P
AD
F
S
R
KL
D
TFQ
T
A
P
L
Q
L
-
-
I
L
DG
RNS
N
S
A
Q
I
AA
N
Y
L
Q
Q
I
VKNYQ
Q
ELLE
G
KPK
P
N
NSE
L
V
V
--
--
R
N
W
YNPNLD
YK
WF
V
VP
S
L
IA
M
I
--
T
T
I
GVM
I
V
T
S
LSV
A
RERE
Q
GT
L
DQ
LLV
S
P
L
T
TW
Q
I
F
I
GK
-
---
A
V
P
A
L
I
V
AT
F
QAT
I
V
LAIGIW
A
Y
QI
P
FA
GS
LA
LF
Y
F
TMV
I
Y
GLSL
V
G
F
GLLIS
S
LCS
T
Q
Q
QA
FI
GV
F
V
F
-
M
M
PA
IL
LSG
YVS
PVE
N
MP
---
V
W
L
Q
N
LTWIN
P
I
R
HF
TD
I
T
K
Q
I
YL
K
D
A
S
L
D
IVW
NS
L
W
PLL
V
I
TATTGSA
AY
AM
FR
RKV
M
fig|478005.5.peg.1410
Escherichia coli O157:H7 str. EC4486
MFHRL
WT
L
I
RKEL
Q
SLLR
E
P
QTRAILILPV
L
I
Q
V
I
L
F
P
F
AA
T
L
---------
E
V
T
NA
T
IAI
Y
D
E
D
N
GEH
S
VEL
T
QR
F
A
R
ASA
F
THV
L
L
L
K
S
P
Q
E
I
R
PT
I
D
TQ
KA
L
L
LV
R
F
P
AD
F
S
R
KL
D
TFQ
T
A
P
L
Q
L
-
-
I
L
DG
RNS
N
S
A
Q
I
AA
N
Y
L
Q
Q
I
VKNYQ
Q
ELLE
G
KPK
P
N
NSE
L
V
V
--
--
R
N
W
YNPNLD
YK
WF
V
VP
S
L
IA
M
I
--
T
T
I
GVM
I
V
T
S
LSV
A
RERE
Q
GT
L
DQ
LLV
S
P
L
T
TW
Q
I
F
I
GK
-
---
A
V
P
A
L
I
V
AT
F
QAT
I
V
LAIGIW
A
Y
QI
P
FA
GS
LA
LF
Y
F
TMV
I
Y
GLSL
V
G
F
GLLIS
S
LCS
T
Q
Q
QA
FI
GV
F
V
F
-
M
M
PA
IL
LSG
YVS
PVE
N
MP
---
V
W
L
Q
N
LTWIN
P
I
R
HF
TD
I
T
K
Q
I
YL
K
D
A
S
L
D
IVW
NS
L
W
PLL
V
I
TATTGSA
AY
AM
FR
RKV
M
fig|478006.5.peg.4621
Escherichia coli O157:H7 str. EC4501
MFHRL
WT
L
I
RKEL
Q
SLLR
E
P
QTRAILILPV
L
I
Q
V
I
L
F
P
F
AA
T
L
---------
E
V
T
NA
T
IAI
Y
D
E
D
N
GEH
S
VEL
T
QR
F
A
R
ASA
F
THV
L
L
L
K
S
P
Q
E
I
R
PT
I
D
TQ
KA
L
L
LV
R
F
P
AD
F
S
R
KL
D
TFQ
T
A
P
L
Q
L
-
-
I
L
DG
RNS
N
S
A
Q
I
AA
N
Y
L
Q
Q
I
VKNYQ
Q
ELLE
G
KPK
P
N
NSE
L
V
V
--
--
R
N
W
YNPNLD
YK
WF
V
VP
S
L
IA
M
I
--
T
T
I
GVM
I
V
T
S
LSV
A
RERE
Q
GT
L
DQ
LLV
S
P
L
T
TW
Q
I
F
I
GK
-
---
A
V
P
A
L
I
V
AT
F
QAT
I
V
LAIGIW
A
Y
QI
P
FA
GS
LA
LF
Y
F
TMV
I
Y
GLSL
V
G
F
GLLIS
S
LCS
T
Q
Q
QA
FI
GV
F
V
F
-
M
M
PA
IL
LSG
YVS
PVE
N
MP
---
V
W
L
Q
N
LTWIN
P
I
R
HF
TD
I
T
K
Q
I
YL
K
D
A
S
L
D
IVW
NS
L
W
PLL
V
I
TATTGSA
AY
AM
FR
RKV
M
fig|478007.5.peg.2643
Escherichia coli O157:H7 str. EC508
MFHRL
WT
L
I
RKEL
Q
SLLR
E
P
QTRAILILPV
L
I
Q
V
I
L
F
P
F
AA
T
L
---------
E
V
T
NA
T
IAI
Y
D
E
D
N
GEH
S
VEL
T
QR
F
A
R
ASA
F
THV
L
L
L
K
S
P
Q
E
I
R
PT
I
D
TQ
KA
L
L
LV
R
F
P
AD
F
S
R
KL
D
TFQ
T
A
P
L
Q
L
-
-
I
L
DG
RNS
N
S
A
Q
I
AA
N
Y
L
Q
Q
I
VKNYQ
Q
ELLE
G
KPK
P
N
NSE
L
V
V
--
--
R
N
W
YNPNLD
YK
WF
V
VP
S
L
IA
M
I
--
T
T
I
GVM
I
V
T
S
LSV
A
RERE
Q
GT
L
DQ
LLV
S
P
L
T
TW
Q
I
F
I
GK
-
---
A
V
P
A
L
I
V
AT
F
QAT
I
V
LAIGIW
A
Y
QI
P
FA
GS
LA
LF
Y
F
TMV
I
Y
GLSL
V
G
F
GLLIS
S
LCS
T
Q
Q
QA
FI
GV
F
V
F
-
M
M
PA
IL
LSG
YVS
PVE
N
MP
---
V
W
L
Q
N
LTWIN
P
I
R
HF
TD
I
T
K
Q
I
YL
K
D
A
S
L
D
IVW
NS
L
W
PLL
V
I
TATTGSA
AY
AM
FR
RKV
M
fig|478008.5.peg.2262
Escherichia coli O157:H7 str. EC869
MFHRL
WT
L
I
RKEL
Q
SLLR
E
P
QTRAILILPV
L
I
Q
V
I
L
F
P
F
AA
T
L
---------
E
V
T
NA
T
IAI
Y
D
E
D
N
GEH
S
VEL
T
QR
F
A
R
ASA
F
THV
L
L
L
K
S
P
Q
E
I
R
PT
I
D
TQ
KA
L
L
LV
R
F
P
AD
F
S
R
KL
D
TFQ
T
A
P
L
Q
L
-
-
I
L
DG
RNS
N
S
A
Q
I
AA
N
Y
L
Q
Q
I
VKNYQ
Q
ELLE
G
KPK
P
N
NSE
L
V
V
--
--
R
N
W
YNPNLD
YK
WF
V
VP
S
L
IA
M
I
--
T
T
I
GVM
I
V
T
S
LSV
A
RERE
Q
GT
L
DQ
LLV
S
P
L
T
TW
Q
I
F
I
GK
-
---
A
V
P
A
L
I
V
AT
F
QAT
I
V
LAIGIW
A
Y
QI
P
FA
GS
LA
LF
Y
F
TMV
I
Y
GLSL
V
G
F
GLLIS
S
LCS
T
Q
Q
QA
FI
GV
F
V
F
-
M
M
PA
IL
LSG
YVS
PVE
N
MP
---
V
W
L
Q
N
LTWIN
P
I
R
HF
TD
I
T
K
Q
I
YL
K
D
A
S
L
D
IVW
NS
L
W
PLL
V
I
TATTGSA
AY
AM
FR
RKV
M
fig|637388.3.peg.2562
Escherichia coli O157:H7 str. FRIK2000
MFHRL
WT
L
I
RKEL
Q
SLLR
E
P
QTRAILILPV
L
I
Q
V
I
L
F
P
F
AA
T
L
---------
E
V
T
NA
T
IAI
Y
D
E
D
N
GEH
S
VEL
T
QR
F
A
R
ASA
F
THV
L
L
L
K
S
P
Q
E
I
R
PT
I
D
TQ
KA
L
L
LV
R
F
P
AD
F
S
R
KL
D
TFQ
T
A
P
L
Q
L
-
-
I
L
DG
RNS
N
S
A
Q
I
AA
N
Y
L
Q
Q
I
VKNYQ
Q
ELLE
G
KPK
P
N
NSE
L
V
V
--
--
R
N
W
YNPNLD
YK
WF
V
VP
S
L
IA
M
I
--
T
T
I
GVM
I
V
T
S
LSV
A
RERE
Q
GT
L
DQ
LLV
S
P
L
T
TW
Q
I
F
I
GK
-
---
A
V
P
A
L
I
V
AT
F
QAT
I
V
LAIGIW
A
Y
QI
P
FA
GS
LA
LF
Y
F
TMV
I
Y
GLSL
V
G
F
GLLIS
S
LCS
T
Q
Q
QA
FI
GV
F
V
F
-
M
M
PA
IL
LSG
YVS
PVE
N
MP
---
V
W
L
Q
N
LTWIN
P
I
R
HF
TD
I
T
K
Q
I
YL
K
D
A
S
L
D
IVW
NS
L
W
PLL
V
I
TATTGSA
AY
AM
FR
RKV
M
fig|570506.3.peg.4467
Escherichia coli O157:H7 str. FRIK966
MFHRL
WT
L
I
RKEL
Q
SLLR
E
P
QTRAILILPV
L
I
Q
V
I
L
F
P
F
AA
T
L
---------
E
V
T
NA
T
IAI
Y
D
E
D
N
GEH
S
VEL
T
QR
F
A
R
ASA
F
THV
L
L
L
K
S
P
Q
E
I
R
PT
I
D
TQ
KA
L
L
LV
R
F
P
AD
F
S
R
KL
D
TFQ
T
A
P
L
Q
L
-
-
I
L
DG
RNS
N
S
A
Q
I
AA
N
Y
L
Q
Q
I
VKNYQ
Q
ELLE
G
KPK
P
N
NSE
L
V
V
--
--
R
N
W
YNPNLD
YK
WF
V
VP
S
L
IA
M
I
--
T
T
I
GVM
I
V
T
S
LSV
A
RERE
Q
GT
L
DQ
LLV
S
P
L
T
TW
Q
I
F
I
GK
-
---
A
V
P
A
L
I
V
AT
F
QAT
I
V
LAIGIW
A
Y
QI
P
FA
GS
LA
LF
Y
F
TMV
I
Y
GLSL
V
G
F
GLLIS
S
LCS
T
Q
Q
QA
FI
GV
F
V
F
-
M
M
PA
IL
LSG
YVS
PVE
N
MP
---
V
W
L
Q
N
LTWIN
P
I
R
HF
TD
I
T
K
Q
I
YL
K
D
A
S
L
D
IVW
NS
L
W
PLL
V
I
TATTGSA
AY
AM
FR
RKV
M
fig|386585.9.peg.984
Escherichia coli O157:H7 str. Sakai
MFHRL
WT
L
I
RKEL
Q
SLLR
E
P
QTRAILILPV
L
I
Q
V
I
L
F
P
F
AA
T
L
---------
E
V
T
NA
T
IAI
Y
D
E
D
N
GEH
S
VEL
T
QR
F
A
R
ASA
F
THV
L
L
L
K
S
P
Q
E
I
R
PT
I
D
TQ
KA
L
L
LV
R
F
P
AD
F
S
R
KL
D
TFQ
T
A
P
L
Q
L
-
-
I
L
DG
RNS
N
S
A
Q
I
AA
N
Y
L
Q
Q
I
VKNYQ
Q
ELLE
G
KPK
P
N
NSE
L
V
V
--
--
R
N
W
YNPNLD
YK
WF
V
VP
S
L
IA
M
I
--
T
T
I
GVM
I
V
T
S
LSV
A
RERE
Q
GT
L
DQ
LLV
S
P
L
T
TW
Q
I
F
I
GK
-
---
A
V
P
A
L
I
V
AT
F
QAT
I
V
LAIGIW
A
Y
QI
P
FA
GS
LA
LF
Y
F
TMV
I
Y
GLSL
V
G
F
GLLIS
S
LCS
T
Q
Q
QA
FI
GV
F
V
F
-
M
M
PA
IL
LSG
YVS
PVE
N
MP
---
V
W
L
Q
N
LTWIN
P
I
R
HF
TD
I
T
K
Q
I
YL
K
D
A
S
L
D
IVW
NS
L
W
PLL
V
I
TATTGSA
AY
AM
FR
RKV
M
fig|544404.4.peg.894
Escherichia coli O157:H7 str. TW14359
MFHRL
WT
L
I
RKEL
Q
SLLR
E
P
QTRAILILPV
L
I
Q
V
I
L
F
P
F
AA
T
L
---------
E
V
T
NA
T
IAI
Y
D
E
D
N
GEH
S
VEL
T
QR
F
A
R
ASA
F
THV
L
L
L
K
S
P
Q
E
I
R
PT
I
D
TQ
KA
L
L
LV
R
F
P
AD
F
S
R
KL
D
TFQ
T
A
P
L
Q
L
-
-
I
L
DG
RNS
N
S
A
Q
I
AA
N
Y
L
Q
Q
I
VKNYQ
Q
ELLE
G
KPK
P
N
NSE
L
V
V
--
--
R
N
W
YNPNLD
YK
WF
V
VP
S
L
IA
M
I
--
T
T
I
GVM
I
V
T
S
LSV
A
RERE
Q
GT
L
DQ
LLV
S
P
L
T
TW
Q
I
F
I
GK
-
---
A
V
P
A
L
I
V
AT
F
QAT
I
V
LAIGIW
A
Y
QI
P
FA
GS
LA
LF
Y
F
TMV
I
Y
GLSL
V
G
F
GLLIS
S
LCS
T
Q
Q
QA
FI
GV
F
V
F
-
M
M
PA
IL
LSG
YVS
PVE
N
MP
---
V
W
L
Q
N
LTWIN
P
I
R
HF
TD
I
T
K
Q
I
YL
K
D
A
S
L
D
IVW
NS
L
W
PLL
V
I
TATTGSA
AY
AM
FR
RKV
M
fig|502346.5.peg.322
Escherichia coli O157:H7 str. TW14588
MFHRL
WT
L
I
RKEL
Q
SLLR
E
P
QTRAILILPV
L
I
Q
V
I
L
F
P
F
AA
T
L
---------
E
V
T
NA
T
IAI
Y
D
E
D
N
GEH
S
VEL
T
QR
F
A
R
ASA
F
THV
L
L
L
K
S
P
Q
E
I
R
PT
I
D
TQ
KA
L
L
LV
R
F
P
AD
F
S
R
KL
D
TFQ
T
A
P
L
Q
L
-
-
I
L
DG
RNS
N
S
A
Q
I
AA
N
Y
L
Q
Q
I
VKNYQ
Q
ELLE
G
KPK
P
N
NSE
L
V
V
--
--
R
N
W
YNPNLD
YK
WF
V
VP
S
L
IA
M
I
--
T
T
I
GVM
I
V
T
S
LSV
A
RERE
Q
GT
L
DQ
LLV
S
P
L
T
TW
Q
I
F
I
GK
-
---
A
V
P
A
L
I
V
AT
F
QAT
I
V
LAIGIW
A
Y
QI
P
FA
GS
LA
LF
Y
F
TMV
I
Y
GLSL
V
G
F
GLLIS
S
LCS
T
Q
Q
QA
FI
GV
F
V
F
-
M
M
PA
IL
LSG
YVS
PVE
N
MP
---
V
W
L
Q
N
LTWIN
P
I
R
HF
TD
I
T
K
Q
I
YL
K
D
A
S
L
D
IVW
NS
L
W
PLL
V
I
TATTGSA
AY
AM
FR
RKV
M
fig|573235.3.peg.933
Escherichia coli O26:H11 str. 11368
MFHRL
WT
L
I
RKEL
Q
SLLR
E
P
QTRAILILPV
L
I
Q
V
I
L
F
P
F
AA
T
L
---------
E
V
T
NA
T
IAI
Y
D
E
D
N
GEH
S
VEL
T
QR
F
A
R
ASA
F
THV
L
L
L
K
S
P
Q
E
I
R
PT
I
D
TQ
KA
L
L
LV
R
F
P
AD
F
S
R
KL
D
TFQ
T
A
P
L
Q
L
-
-
I
L
DG
RNS
N
S
A
Q
I
AA
N
Y
L
Q
Q
I
VKNYQ
Q
ELLE
G
KPK
P
N
NSE
L
V
V
--
--
R
N
W
YNPNLD
YK
WF
V
VP
S
L
IA
M
I
--
T
T
I
GVM
I
V
T
S
LSV
A
RERE
Q
GT
L
DQ
LLV
S
P
L
T
TW
Q
I
F
I
GK
-
---
A
V
P
A
L
I
V
AT
F
QAT
I
V
LAIGIW
A
Y
QI
P
FA
GS
LA
LF
Y
F
TMV
I
Y
GLSL
V
G
F
GLLIS
S
LCS
T
Q
Q
QA
FI
GV
F
V
F
-
M
M
PA
IL
LSG
YVS
PVE
N
MP
---
V
W
L
Q
N
LTWIN
P
I
R
HF
TD
I
T
K
Q
I
YL
K
D
A
S
L
D
IVW
NS
L
W
PLL
V
I
TATTGSA
AY
AM
FR
RKV
M
fig|701177.3.peg.1002
Escherichia coli O55:H7 str. CB9615
MFHRL
WT
L
I
RKEL
Q
SLLR
E
P
QTRAILILPV
L
I
Q
V
I
L
F
P
F
AA
T
L
---------
E
V
T
NA
T
IAI
Y
D
E
D
N
GEH
S
VEL
T
QR
F
A
R
ASA
F
THV
L
L
L
K
S
P
Q
E
I
R
PT
I
D
TQ
KA
L
L
LV
R
F
P
AD
F
S
R
KL
D
TFQ
T
A
P
L
Q
L
-
-
I
L
DG
RNS
N
S
A
Q
I
AA
N
Y
L
Q
Q
I
VKNYQ
Q
ELLE
G
KPK
P
N
NSE
L
V
V
--
--
R
N
W
YNPNLD
YK
WF
V
VP
S
L
IA
M
I
--
T
T
I
GVM
I
V
T
S
LSV
A
RERE
Q
GT
L
DQ
LLV
S
P
L
T
TW
Q
I
F
I
GK
-
---
A
V
P
A
L
I
V
AT
F
QAT
I
V
LAIGIW
A
Y
QI
P
FA
GS
LA
LF
Y
F
TMV
I
Y
GLSL
V
G
F
GLLIS
S
LCS
T
Q
Q
QA
FI
GV
F
V
F
-
M
M
PA
IL
LSG
YVS
PVE
N
MP
---
V
W
L
Q
N
LTWIN
P
I
R
HF
TD
I
T
K
Q
I
YL
K
D
A
S
L
D
IVW
NS
L
W
PLL
V
I
TATTGSA
AY
AM
FR
RKV
M
fig|685038.3.peg.717
Escherichia coli O83:H1 str. NRG 857C
MFHRL
WT
L
I
RKEL
Q
SLLR
E
P
QTRAILILPV
L
I
Q
V
I
L
F
P
F
AA
T
L
---------
E
V
T
NA
T
IAI
Y
D
E
D
N
GEH
S
VEL
T
QR
F
A
R
ASA
F
THV
L
L
L
K
S
P
Q
E
I
R
PT
I
D
TQ
KA
L
L
LV
R
F
P
AD
F
S
R
KL
D
TFQ
T
A
P
L
Q
L
-
-
I
L
DG
RNS
N
S
A
Q
I
AA
N
Y
L
Q
Q
I
VKNYQ
Q
ELLE
G
KPK
P
N
NSE
L
V
V
--
--
R
N
W
YNPNLD
YK
WF
V
VP
S
L
IA
M
I
--
T
T
I
GVM
I
V
T
S
LSV
A
RERE
Q
GT
L
DQ
LLV
S
P
L
T
TW
Q
I
F
I
GK
-
---
A
V
P
A
L
I
V
AT
F
QAT
I
V
LAIGIW
A
Y
QI
P
FA
GS
LA
LF
Y
F
TMV
I
Y
GLSL
V
G
F
GLLIS
S
LCS
T
Q
Q
QA
FI
GV
F
V
F
-
M
M
PA
IL
LSG
YVS
PVE
N
MP
---
V
W
L
Q
N
LTWIN
P
I
R
HF
TD
I
T
K
Q
I
YL
K
D
A
S
L
D
IVW
NS
L
W
PLL
V
I
TATTGSA
AY
AM
FR
RKV
M
fig|637912.3.peg.2691
Escherichia coli OP50
MFHRL
WT
L
I
RKEL
Q
SLLR
E
P
QTRAILILPV
L
I
Q
V
I
L
F
P
F
AA
T
L
---------
E
V
T
NA
T
IAI
Y
D
E
D
N
GEH
S
VEL
T
QR
F
A
R
ASA
F
THV
L
L
L
K
S
P
Q
E
I
R
PT
I
D
TQ
KA
L
L
LV
R
F
P
AD
F
S
R
KL
D
TFQ
T
A
P
L
Q
L
-
-
I
L
DG
RNS
N
S
A
Q
I
AA
N
Y
L
Q
Q
I
VKNYQ
Q
ELLE
G
KPK
P
N
NSE
L
V
V
--
--
R
N
W
YNPNLD
YK
WF
V
VP
S
L
IA
M
I
--
T
T
I
GVM
I
V
T
S
LSV
A
RERE
Q
GT
L
DQ
LLV
S
P
L
T
TW
Q
I
F
I
GK
-
---
A
V
P
A
L
I
V
AT
F
QAT
I
V
LAIGIW
A
Y
QI
P
FA
GS
LA
LF
Y
F
TMV
I
Y
GLSL
V
G
F
GLLIS
S
LCS
T
Q
Q
QA
FI
GV
F
V
F
-
M
M
PA
IL
LSG
YVS
PVE
N
MP
---
V
W
L
Q
N
LTWIN
P
I
R
HF
TD
I
T
K
Q
I
YL
K
D
A
S
L
D
IVW
NS
L
W
PLL
V
I
TATTGSA
AY
AM
FR
RKV
M
fig|585035.6.peg.810
Escherichia coli S88
MFHRL
WT
L
I
RKEL
Q
SLLR
E
P
QTRAILILPV
L
I
Q
V
I
L
F
P
F
AA
T
L
---------
E
V
T
NA
T
IAI
Y
D
E
D
N
GEH
S
VEL
T
QR
F
A
R
ASA
F
THV
L
L
L
K
S
P
Q
E
I
R
PT
I
D
TQ
KA
L
L
LV
R
F
P
AD
F
S
R
KL
D
TFQ
T
A
P
L
Q
L
-
-
I
L
DG
RNS
N
S
A
Q
I
AA
N
Y
L
Q
Q
I
VKNYQ
Q
ELLE
G
KPK
P
N
NSE
L
V
V
--
--
R
N
W
YNPNLD
YK
WF
V
VP
S
L
IA
M
I
--
T
T
I
GVM
I
V
T
S
LSV
A
RERE
Q
GT
L
DQ
LLV
S
P
L
T
TW
Q
I
F
I
GK
-
---
A
V
P
A
L
I
V
AT
F
QAT
I
V
LAIGIW
A
Y
QI
P
FA
GS
LA
LF
Y
F
TMV
I
Y
GLSL
V
G
F
GLLIS
S
LCS
T
Q
Q
QA
FI
GV
F
V
F
-
M
M
PA
IL
LSG
YVS
PVE
N
MP
---
V
W
L
Q
N
LTWIN
P
I
R
HF
TD
I
T
K
Q
I
YL
K
D
A
S
L
D
IVW
NS
L
W
PLL
V
I
TATTGSA
AY
AM
FR
RKV
M
fig|409438.11.peg.973
Escherichia coli SE11
MFHRL
WT
L
I
RKEL
Q
SLLR
E
P
QTRAILILPV
L
I
Q
V
I
L
F
P
F
AA
T
L
---------
E
V
T
NA
T
IAI
Y
D
E
D
N
GEH
S
VEL
T
QR
F
A
R
ASA
F
THV
L
L
L
K
S
P
Q
E
I
R
PT
I
D
TQ
KA
L
L
LV
R
F
P
AD
F
S
R
KL
D
TFQ
T
A
P
L
Q
L
-
-
I
L
DG
RNS
N
S
A
Q
I
AA
N
Y
L
Q
Q
I
VKNYQ
Q
ELLE
G
KPK
P
N
NSE
L
V
V
--
--
R
N
W
YNPNLD
YK
WF
V
VP
S
L
IA
M
I
--
T
T
I
GVM
I
V
T
S
LSV
A
RERE
Q
GT
L
DQ
LLV
S
P
L
T
TW
Q
I
F
I
GK
-
---
A
V
P
A
L
I
V
AT
F
QAT
I
V
LAIGIW
A
Y
QI
P
FA
GS
LA
LF
Y
F
TMV
I
Y
GLSL
V
G
F
GLLIS
S
LCS
T
Q
Q
QA
FI
GV
F
V
F
-
M
M
PA
IL
LSG
YVS
PVE
N
MP
---
V
W
L
Q
N
LTWIN
P
I
R
HF
TD
I
T
K
Q
I
YL
K
D
A
S
L
D
IVW
NS
L
W
PLL
V
I
TATTGSA
AY
AM
FR
RKV
M
fig|431946.3.peg.752
Escherichia coli SE15
MFHRL
WT
L
I
RKEL
Q
SLLR
E
P
QTRAILILPV
L
I
Q
V
I
L
F
P
F
AA
T
L
---------
E
V
T
NA
T
IAI
Y
D
E
D
N
GEH
S
VEL
T
QR
F
A
R
ASA
F
THV
L
L
L
K
S
P
Q
E
I
R
PT
I
D
TQ
KA
L
L
LV
R
F
P
AD
F
S
R
KL
D
TFQ
T
A
P
L
Q
L
-
-
I
L
DG
RNS
N
S
A
Q
I
AA
N
Y
L
Q
Q
I
VKNYQ
Q
ELLE
G
KPK
P
N
NSE
L
V
V
--
--
R
N
W
YNPNLD
YK
WF
V
VP
S
L
IA
M
I
--
T
T
I
GVM
I
V
T
S
LSV
A
RERE
Q
GT
L
DQ
LLV
S
P
L
T
TW
Q
I
F
I
GK
-
---
A
V
P
A
L
I
V
AT
F
QAT
I
V
LAIGIW
A
Y
QI
P
FA
GS
LA
LF
Y
F
TMV
I
Y
GLSL
V
G
F
GLLIS
S
LCS
T
Q
Q
QA
FI
GV
F
V
F
-
M
M
PA
IL
LSG
YVS
PVE
N
MP
---
V
W
L
Q
N
LTWIN
P
I
R
HF
TD
I
T
K
Q
I
YL
K
D
A
S
L
D
IVW
NS
L
W
PLL
V
I
TATTGSA
AY
AM
FR
RKV
M
fig|439855.10.peg.972
Escherichia coli SMS-3-5
MFHRL
WT
L
I
RKEL
Q
SLLR
E
P
QTRAILILPV
L
I
Q
V
I
L
F
P
F
AA
T
L
---------
E
V
T
NA
T
IAI
Y
D
E
D
N
GEH
S
VEL
T
QR
F
A
R
ASA
F
THV
L
L
L
K
S
P
Q
E
I
R
PT
I
D
TQ
KA
L
L
LV
R
F
P
AD
F
S
R
KL
D
TFQ
T
A
P
L
Q
L
-
-
I
L
DG
RNS
N
S
A
Q
I
AA
N
Y
L
Q
Q
I
VKNYQ
Q
ELLE
G
KPK
P
N
NSE
L
V
V
--
--
R
N
W
YNPNLD
YK
WF
V
VP
S
L
IA
M
I
--
T
T
I
GVM
I
V
T
S
LSV
A
RERE
Q
GT
L
DQ
LLV
S
P
L
T
TW
Q
I
F
I
GK
-
---
A
V
P
A
L
I
V
AT
F
QAT
I
V
LAIGIW
A
Y
QI
P
FA
GS
LA
LF
Y
F
TMV
I
Y
GLSL
V
G
F
GLLIS
S
LCS
T
Q
Q
QA
FI
GV
F
V
F
-
M
M
PA
IL
LSG
YVS
PVE
N
MP
---
V
W
L
Q
N
LTWIN
P
I
R
HF
TD
I
T
K
Q
I
YL
K
D
A
S
L
D
IVW
NS
L
W
PLL
V
I
TATTGSA
AY
AM
FR
RKV
M
fig|656437.3.peg.872
Escherichia coli TA143
MFHRL
WT
L
I
RKEL
Q
SLLR
E
P
QTRAILILPV
L
I
Q
V
I
L
F
P
F
AA
T
L
---------
E
V
T
NA
T
IAI
Y
D
E
D
N
GEH
S
VEL
T
QR
F
A
R
ASA
F
THV
L
L
L
K
S
P
Q
E
I
R
PT
I
D
TQ
KA
L
L
LV
R
F
P
AD
F
S
R
KL
D
TFQ
T
A
P
L
Q
L
-
-
I
L
DG
RNS
N
S
A
Q
I
AA
N
Y
L
Q
Q
I
VKNYQ
Q
ELLE
G
KPK
P
N
NSE
L
V
V
--
--
R
N
W
YNPNLD
YK
WF
V
VP
S
L
IA
M
I
--
T
T
I
GVM
I
V
T
S
LSV
A
RERE
Q
GT
L
DQ
LLV
S
P
L
T
TW
Q
I
F
I
GK
-
---
A
V
P
A
L
I
V
AT
F
QAT
I
V
LAIGIW
A
Y
QI
P
FA
GS
LA
LF
Y
F
TMV
I
Y
GLSL
V
G
F
GLLIS
S
LCS
T
Q
Q
QA
FI
GV
F
V
F
-
M
M
PA
IL
LSG
YVS
PVE
N
MP
---
V
W
L
Q
N
LTWIN
P
I
R
HF
TD
I
T
K
Q
I
YL
K
D
A
S
L
D
IVW
NS
L
W
PLL
V
I
TATTGSA
AY
AM
FR
RKV
M
fig|656440.3.peg.644
Escherichia coli TA206
MFHRL
WT
L
I
RKEL
Q
SLLR
E
P
QTRAILILPV
L
I
Q
V
I
L
F
P
F
AA
T
L
---------
E
V
T
NA
T
IAI
Y
D
E
D
N
GEH
S
VEL
T
QR
F
A
R
ASA
F
THV
L
L
L
K
S
P
Q
E
I
R
PT
I
D
TQ
KA
L
L
LV
R
F
P
AD
F
S
R
KL
D
TFQ
T
A
P
L
Q
L
-
-
I
L
DG
RNS
N
S
A
Q
I
AA
N
Y
L
Q
Q
I
VKNYQ
Q
ELLE
G
KPK
P
N
NSE
L
V
V
--
--
R
N
W
YNPNLD
YK
WF
V
VP
S
L
IA
M
I
--
T
T
I
GVM
I
V
T
S
LSV
A
RERE
Q
GT
L
DQ
LLV
S
P
L
T
TW
Q
I
F
I
GK
-
---
A
V
P
A
L
I
V
AT
F
QAT
I
V
LAIGIW
A
Y
QI
P
FA
GS
LA
LF
Y
F
TMV
I
Y
GLSL
V
G
F
GLLIS
S
LCS
T
Q
Q
QA
FI
GV
F
V
F
-
M
M
PA
IL
LSG
YVS
PVE
N
MP
---
V
W
L
Q
N
LTWIN
P
I
R
HF
TD
I
T
K
Q
I
YL
K
D
A
S
L
D
IVW
NS
L
W
PLL
V
I
TATTGSA
AY
AM
FR
RKV
M
fig|656443.3.peg.1062
Escherichia coli TA271
MFHRL
WT
L
I
RKEL
Q
SLLR
E
P
QTRAILILPV
L
I
Q
V
I
L
F
P
F
AA
T
L
---------
E
V
T
NA
T
IAI
Y
D
E
D
N
GEH
S
VEL
T
QR
F
A
R
ASA
F
THV
L
L
L
K
S
P
Q
E
I
R
PT
I
D
TQ
KA
L
L
LV
R
F
P
AD
F
S
R
KL
D
TFQ
T
A
P
L
Q
L
-
-
I
L
DG
RNS
N
S
A
Q
I
AA
N
Y
L
Q
Q
I
VKNYQ
Q
ELLE
G
KPK
P
N
NSE
L
V
V
--
--
R
N
W
YNPNLD
YK
WF
V
VP
S
L
IA
M
I
--
T
T
I
GVM
I
V
T
S
LSV
A
RERE
Q
GT
L
DQ
LLV
S
P
L
T
TW
Q
I
F
I
GK
-
---
A
V
P
A
L
I
V
AT
F
QAT
I
V
LAIGIW
A
Y
QI
P
FA
GS
LA
LF
Y
F
TMV
I
Y
GLSL
V
G
F
GLLIS
S
LCS
T
Q
Q
QA
FI
GV
F
V
F
-
M
M
PA
IL
LSG
YVS
PVE
N
MP
---
V
W
L
Q
N
LTWIN
P
I
R
HF
TD
I
T
K
Q
I
YL
K
D
A
S
L
D
IVW
NS
L
W
PLL
V
I
TATTGSA
AY
AM
FR
RKV
M
fig|656444.3.peg.1341
Escherichia coli TA280
MFHRL
WT
L
I
RKEL
Q
SLLR
E
P
QTRAILILPV
L
I
Q
V
I
L
F
P
F
AA
T
L
---------
E
V
T
NA
T
IAI
Y
D
E
D
N
GEH
S
VEL
T
QR
F
A
R
ASA
F
THV
L
L
L
K
S
P
Q
E
I
R
PT
I
D
TQ
KA
L
L
LV
R
F
P
AD
F
S
R
KL
D
TFQ
T
A
P
L
Q
L
-
-
I
L
DG
RNS
N
S
A
Q
I
AA
N
Y
L
Q
Q
I
VKNYQ
Q
ELLE
G
KPK
P
N
NSE
L
V
V
--
--
R
N
W
YNPNLD
YK
WF
V
VP
S
L
IA
M
I
--
T
T
I
GVM
I
V
T
S
LSV
A
RERE
Q
GT
L
DQ
LLV
S
P
L
T
TW
Q
I
F
I
GK
-
---
A
V
P
A
L
I
V
AT
F
QAT
I
V
LAIGIW
A
Y
QI
P
FA
GS
LA
LF
Y
F
TMV
I
Y
GLSL
V
G
F
GLLIS
S
LCS
T
Q
Q
QA
FI
GV
F
V
F
-
M
M
PA
IL
LSG
YVS
PVE
N
MP
---
V
W
L
Q
N
LTWIN
P
I
R
HF
TD
I
T
K
Q
I
YL
K
D
A
S
L
D
IVW
NS
L
W
PLL
V
I
TATTGSA
AY
AM
FR
RKV
M
fig|869729.3.peg.2922
Escherichia coli UM146
MFHRL
WT
L
I
RKEL
Q
SLLR
E
P
QTRAILILPV
L
I
Q
V
I
L
F
P
F
AA
T
L
---------
E
V
T
NA
T
IAI
Y
D
E
D
N
GEH
S
VEL
T
QR
F
A
R
ASA
F
THV
L
L
L
K
S
P
Q
E
I
R
PT
I
D
TQ
KA
L
L
LV
R
F
P
AD
F
S
R
KL
D
TFQ
T
A
P
L
Q
L
-
-
I
L
DG
RNS
N
S
A
Q
I
AA
N
Y
L
Q
Q
I
VKNYQ
Q
ELLE
G
KPK
P
N
NSE
L
V
V
--
--
R
N
W
YNPNLD
YK
WF
V
VP
S
L
IA
M
I
--
T
T
I
GVM
I
V
T
S
LSV
A
RERE
Q
GT
L
DQ
LLV
S
P
L
T
TW
Q
I
F
I
GK
-
---
A
V
P
A
L
I
V
AT
F
QAT
I
V
LAIGIW
A
Y
QI
P
FA
GS
LA
LF
Y
F
TMV
I
Y
GLSL
V
G
F
GLLIS
S
LCS
T
Q
Q
QA
FI
GV
F
V
F
-
M
M
PA
IL
LSG
YVS
PVE
N
MP
---
V
W
L
Q
N
LTWIN
P
I
R
HF
TD
I
T
K
Q
I
YL
K
D
A
S
L
D
IVW
NS
L
W
PLL
V
I
TATTGSA
AY
AM
FR
RKV
M
fig|585056.7.peg.1130
Escherichia coli UMN026
MFHRL
WT
L
I
RKEL
Q
SLLR
E
P
QTRAILILPV
L
I
Q
V
I
L
F
P
F
AA
T
L
---------
E
V
T
NA
T
IAI
Y
D
E
D
N
GEH
S
VEL
T
QR
F
A
R
ASA
F
THV
L
L
L
K
S
P
Q
E
I
R
PT
I
D
TQ
KA
L
L
LV
R
F
P
AD
F
S
R
KL
D
TFQ
T
A
P
L
Q
L
-
-
I
L
DG
RNS
N
S
A
Q
I
AA
N
Y
L
Q
Q
I
VKNYQ
Q
ELLE
G
KPK
P
N
NSE
L
V
V
--
--
R
N
W
YNPNLD
YK
WF
V
VP
S
L
IA
M
I
--
T
T
I
GVM
I
V
T
S
LSV
A
RERE
Q
GT
L
DQ
LLV
S
P
L
T
TW
Q
I
F
I
GK
-
---
A
V
P
A
L
I
V
AT
F
QAT
I
V
LAIGIW
A
Y
QI
P
FA
GS
LA
LF
Y
F
TMV
I
Y
GLSL
V
G
F
GLLIS
S
LCS
T
Q
Q
QA
FI
GV
F
V
F
-
M
M
PA
IL
LSG
YVS
PVE
N
MP
---
V
W
L
Q
N
LTWIN
P
I
R
HF
TD
I
T
K
Q
I
YL
K
D
A
S
L
D
IVW
NS
L
W
PLL
V
I
TATTGSA
AY
AM
FR
RKV
M
fig|364106.7.peg.879
Escherichia coli UTI89
MFHRL
WT
L
I
RKEL
Q
SLLR
E
P
QTRAILILPV
L
I
Q
V
I
L
F
P
F
AA
T
L
---------
E
V
T
NA
T
IAI
Y
D
E
D
N
GEH
S
VEL
T
QR
F
A
R
ASA
F
THV
L
L
L
K
S
P
Q
E
I
R
PT
I
D
TQ
KA
L
L
LV
R
F
P
AD
F
S
R
KL
D
TFQ
T
A
P
L
Q
L
-
-
I
L
DG
RNS
N
S
A
Q
I
AA
N
Y
L
Q
Q
I
VKNYQ
Q
ELLE
G
KPK
P
N
NSE
L
V
V
--
--
R
N
W
YNPNLD
YK
WF
V
VP
S
L
IA
M
I
--
T
T
I
GVM
I
V
T
S
LSV
A
RERE
Q
GT
L
DQ
LLV
S
P
L
T
TW
Q
I
F
I
GK
-
---
A
V
P
A
L
I
V
AT
F
QAT
I
V
LAIGIW
A
Y
QI
P
FA
GS
LA
LF
Y
F
TMV
I
Y
GLSL
V
G
F
GLLIS
S
LCS
T
Q
Q
QA
FI
GV
F
V
F
-
M
M
PA
IL
LSG
YVS
PVE
N
MP
---
V
W
L
Q
N
LTWIN
P
I
R
HF
TD
I
T
K
Q
I
YL
K
D
A
S
L
D
IVW
NS
L
W
PLL
V
I
TATTGSA
AY
AM
FR
RKV
M
fig|364106.8.peg.878
Escherichia coli UTI89
MFHRL
WT
L
I
RKEL
Q
SLLR
E
P
QTRAILILPV
L
I
Q
V
I
L
F
P
F
AA
T
L
---------
E
V
T
NA
T
IAI
Y
D
E
D
N
GEH
S
VEL
T
QR
F
A
R
ASA
F
THV
L
L
L
K
S
P
Q
E
I
R
PT
I
D
TQ
KA
L
L
LV
R
F
P
AD
F
S
R
KL
D
TFQ
T
A
P
L
Q
L
-
-
I
L
DG
RNS
N
S
A
Q
I
AA
N
Y
L
Q
Q
I
VKNYQ
Q
ELLE
G
KPK
P
N
NSE
L
V
V
--
--
R
N
W
YNPNLD
YK
WF
V
VP
S
L
IA
M
I
--
T
T
I
GVM
I
V
T
S
LSV
A
RERE
Q
GT
L
DQ
LLV
S
P
L
T
TW
Q
I
F
I
GK
-
---
A
V
P
A
L
I
V
AT
F
QAT
I
V
LAIGIW
A
Y
QI
P
FA
GS
LA
LF
Y
F
TMV
I
Y
GLSL
V
G
F
GLLIS
S
LCS
T
Q
Q
QA
FI
GV
F
V
F
-
M
M
PA
IL
LSG
YVS
PVE
N
MP
---
V
W
L
Q
N
LTWIN
P
I
R
HF
TD
I
T
K
Q
I
YL
K
D
A
S
L
D
IVW
NS
L
W
PLL
V
I
TATTGSA
AY
AM
FR
RKV
M
fig|566546.3.peg.3775
Escherichia coli W
MFHRL
WT
L
I
RKEL
Q
SLLR
E
P
QTRAILILPV
L
I
Q
V
I
L
F
P
F
AA
T
L
---------
E
V
T
NA
T
IAI
Y
D
E
D
N
GEH
S
VEL
T
QR
F
A
R
ASA
F
THV
L
L
L
K
S
P
Q
E
I
R
PT
I
D
TQ
KA
L
L
LV
R
F
P
AD
F
S
R
KL
D
TFQ
T
A
P
L
Q
L
-
-
I
L
DG
RNS
N
S
A
Q
I
AA
N
Y
L
Q
Q
I
VKNYQ
Q
ELLE
G
KPK
P
N
NSE
L
V
V
--
--
R
N
W
YNPNLD
YK
WF
V
VP
S
L
IA
M
I
--
T
T
I
GVM
I
V
T
S
LSV
A
RERE
Q
GT
L
DQ
LLV
S
P
L
T
TW
Q
I
F
I
GK
-
---
A
V
P
A
L
I
V
AT
F
QAT
I
V
LAIGIW
A
Y
QI
P
FA
GS
LA
LF
Y
F
TMV
I
Y
GLSL
V
G
F
GLLIS
S
LCS
T
Q
Q
QA
FI
GV
F
V
F
-
M
M
PA
IL
LSG
YVS
PVE
N
MP
---
V
W
L
Q
N
LTWIN
P
I
R
HF
TD
I
T
K
Q
I
YL
K
D
A
S
L
D
IVW
NS
L
W
PLL
V
I
TATTGSA
AY
AM
FR
RKV
M
fig|566546.4.peg.841
Escherichia coli W
MFHRL
WT
L
I
RKEL
Q
SLLR
E
P
QTRAILILPV
L
I
Q
V
I
L
F
P
F
AA
T
L
---------
E
V
T
NA
T
IAI
Y
D
E
D
N
GEH
S
VEL
T
QR
F
A
R
ASA
F
THV
L
L
L
K
S
P
Q
E
I
R
PT
I
D
TQ
KA
L
L
LV
R
F
P
AD
F
S
R
KL
D
TFQ
T
A
P
L
Q
L
-
-
I
L
DG
RNS
N
S
A
Q
I
AA
N
Y
L
Q
Q
I
VKNYQ
Q
ELLE
G
KPK
P
N
NSE
L
V
V
--
--
R
N
W
YNPNLD
YK
WF
V
VP
S
L
IA
M
I
--
T
T
I
GVM
I
V
T
S
LSV
A
RERE
Q
GT
L
DQ
LLV
S
P
L
T
TW
Q
I
F
I
GK
-
---
A
V
P
A
L
I
V
AT
F
QAT
I
V
LAIGIW
A
Y
QI
P
FA
GS
LA
LF
Y
F
TMV
I
Y
GLSL
V
G
F
GLLIS
S
LCS
T
Q
Q
QA
FI
GV
F
V
F
-
M
M
PA
IL
LSG
YVS
PVE
N
MP
---
V
W
L
Q
N
LTWIN
P
I
R
HF
TD
I
T
K
Q
I
YL
K
D
A
S
L
D
IVW
NS
L
W
PLL
V
I
TATTGSA
AY
AM
FR
RKV
M
fig|316407.3.peg.759
Escherichia coli W3110
MFHRL
WT
L
I
RKEL
Q
SLLR
E
P
QTRAILILPV
L
I
Q
V
I
L
F
P
F
AA
T
L
---------
E
V
T
NA
T
IAI
Y
D
E
D
N
GEH
S
VEL
T
QR
F
A
R
ASA
F
THV
L
L
L
K
S
P
Q
E
I
R
PT
I
D
TQ
KA
L
L
LV
R
F
P
AD
F
S
R
KL
D
TFQ
T
A
P
L
Q
L
-
-
I
L
DG
RNS
N
S
A
Q
I
AA
N
Y
L
Q
Q
I
VKNYQ
Q
ELLE
G
KPK
P
N
NSE
L
V
V
--
--
R
N
W
YNPNLD
YK
WF
V
VP
S
L
IA
M
I
--
T
T
I
GVM
I
V
T
S
LSV
A
RERE
Q
GT
L
DQ
LLV
S
P
L
T
TW
Q
I
F
I
GK
-
---
A
V
P
A
L
I
V
AT
F
QAT
I
V
LAIGIW
A
Y
QI
P
FA
GS
LA
LF
Y
F
TMV
I
Y
GLSL
V
G
F
GLLIS
S
LCS
T
Q
Q
QA
FI
GV
F
V
F
-
M
M
PA
IL
LSG
YVS
PVE
N
MP
---
V
W
L
Q
N
LTWIN
P
I
R
HF
TD
I
T
K
Q
I
YL
K
D
A
S
L
D
IVW
NS
L
W
PLL
V
I
TATTGSA
AY
AM
FR
RKV
M
fig|316385.5.peg.855
Escherichia coli str. K-12 substr. DH10B
MFHRL
WT
L
I
RKEL
Q
SLLR
E
P
QTRAILILPV
L
I
Q
V
I
L
F
P
F
AA
T
L
---------
E
V
T
NA
T
IAI
Y
D
E
D
N
GEH
S
VEL
T
QR
F
A
R
ASA
F
THV
L
L
L
K
S
P
Q
E
I
R
PT
I
D
TQ
KA
L
L
LV
R
F
P
AD
F
S
R
KL
D
TFQ
T
A
P
L
Q
L
-
-
I
L
DG
RNS
N
S
A
Q
I
AA
N
Y
L
Q
Q
I
VKNYQ
Q
ELLE
G
KPK
P
N
NSE
L
V
V
--
--
R
N
W
YNPNLD
YK
WF
V
VP
S
L
IA
M
I
--
T
T
I
GVM
I
V
T
S
LSV
A
RERE
Q
GT
L
DQ
LLV
S
P
L
T
TW
Q
I
F
I
GK
-
---
A
V
P
A
L
I
V
AT
F
QAT
I
V
LAIGIW
A
Y
QI
P
FA
GS
LA
LF
Y
F
TMV
I
Y
GLSL
V
G
F
GLLIS
S
LCS
T
Q
Q
QA
FI
GV
F
V
F
-
M
M
PA
IL
LSG
YVS
PVE
N
MP
---
V
W
L
Q
N
LTWIN
P
I
R
HF
TD
I
T
K
Q
I
YL
K
D
A
S
L
D
IVW
NS
L
W
PLL
V
I
TATTGSA
AY
AM
FR
RKV
M
fig|316385.7.peg.867
Escherichia coli str. K-12 substr. DH10B
MFHRL
WT
L
I
RKEL
Q
SLLR
E
P
QTRAILILPV
L
I
Q
V
I
L
F
P
F
AA
T
L
---------
E
V
T
NA
T
IAI
Y
D
E
D
N
GEH
S
VEL
T
QR
F
A
R
ASA
F
THV
L
L
L
K
S
P
Q
E
I
R
PT
I
D
TQ
KA
L
L
LV
R
F
P
AD
F
S
R
KL
D
TFQ
T
A
P
L
Q
L
-
-
I
L
DG
RNS
N
S
A
Q
I
AA
N
Y
L
Q
Q
I
VKNYQ
Q
ELLE
G
KPK
P
N
NSE
L
V
V
--
--
R
N
W
YNPNLD
YK
WF
V
VP
S
L
IA
M
I
--
T
T
I
GVM
I
V
T
S
LSV
A
RERE
Q
GT
L
DQ
LLV
S
P
L
T
TW
Q
I
F
I
GK
-
---
A
V
P
A
L
I
V
AT
F
QAT
I
V
LAIGIW
A
Y
QI
P
FA
GS
LA
LF
Y
F
TMV
I
Y
GLSL
V
G
F
GLLIS
S
LCS
T
Q
Q
QA
FI
GV
F
V
F
-
M
M
PA
IL
LSG
YVS
PVE
N
MP
---
V
W
L
Q
N
LTWIN
P
I
R
HF
TD
I
T
K
Q
I
YL
K
D
A
S
L
D
IVW
NS
L
W
PLL
V
I
TATTGSA
AY
AM
FR
RKV
M
fig|511145.12.peg.818
Escherichia coli str. K-12 substr. MG1655
MFHRL
WT
L
I
RKEL
Q
SLLR
E
P
QTRAILILPV
L
I
Q
V
I
L
F
P
F
AA
T
L
---------
E
V
T
NA
T
IAI
Y
D
E
D
N
GEH
S
VEL
T
QR
F
A
R
ASA
F
THV
L
L
L
K
S
P
Q
E
I
R
PT
I
D
TQ
KA
L
L
LV
R
F
P
AD
F
S
R
KL
D
TFQ
T
A
P
L
Q
L
-
-
I
L
DG
RNS
N
S
A
Q
I
AA
N
Y
L
Q
Q
I
VKNYQ
Q
ELLE
G
KPK
P
N
NSE
L
V
V
--
--
R
N
W
YNPNLD
YK
WF
V
VP
S
L
IA
M
I
--
T
T
I
GVM
I
V
T
S
LSV
A
RERE
Q
GT
L
DQ
LLV
S
P
L
T
TW
Q
I
F
I
GK
-
---
A
V
P
A
L
I
V
AT
F
QAT
I
V
LAIGIW
A
Y
QI
P
FA
GS
LA
LF
Y
F
TMV
I
Y
GLSL
V
G
F
GLLIS
S
LCS
T
Q
Q
QA
FI
GV
F
V
F
-
M
M
PA
IL
LSG
YVS
PVE
N
MP
---
V
W
L
Q
N
LTWIN
P
I
R
HF
TD
I
T
K
Q
I
YL
K
D
A
S
L
D
IVW
NS
L
W
PLL
V
I
TATTGSA
AY
AM
FR
RKV
M
fig|511145.6.peg.810
Escherichia coli str. K-12 substr. MG1655
MFHRL
WT
L
I
RKEL
Q
SLLR
E
P
QTRAILILPV
L
I
Q
V
I
L
F
P
F
AA
T
L
---------
E
V
T
NA
T
IAI
Y
D
E
D
N
GEH
S
VEL
T
QR
F
A
R
ASA
F
THV
L
L
L
K
S
P
Q
E
I
R
PT
I
D
TQ
KA
L
L
LV
R
F
P
AD
F
S
R
KL
D
TFQ
T
A
P
L
Q
L
-
-
I
L
DG
RNS
N
S
A
Q
I
AA
N
Y
L
Q
Q
I
VKNYQ
Q
ELLE
G
KPK
P
N
NSE
L
V
V
--
--
R
N
W
YNPNLD
YK
WF
V
VP
S
L
IA
M
I
--
T
T
I
GVM
I
V
T
S
LSV
A
RERE
Q
GT
L
DQ
LLV
S
P
L
T
TW
Q
I
F
I
GK
-
---
A
V
P
A
L
I
V
AT
F
QAT
I
V
LAIGIW
A
Y
QI
P
FA
GS
LA
LF
Y
F
TMV
I
Y
GLSL
V
G
F
GLLIS
S
LCS
T
Q
Q
QA
FI
GV
F
V
F
-
M
M
PA
IL
LSG
YVS
PVE
N
MP
---
V
W
L
Q
N
LTWIN
P
I
R
HF
TD
I
T
K
Q
I
YL
K
D
A
S
L
D
IVW
NS
L
W
PLL
V
I
TATTGSA
AY
AM
FR
RKV
M
fig|155864.1.peg.863
Escherichia coli O157:H7 EDL933
MFHRL
WT
L
I
RKEL
Q
SLLR
E
P
QTRAILILPV
L
I
Q
V
I
L
F
P
F
AA
T
L
---------
E
V
T
NA
T
IAI
Y
D
E
D
N
GEH
S
VEL
T
QR
F
A
R
ASA
F
THV
L
L
L
K
S
P
Q
E
I
R
PT
I
D
TQ
KA
L
L
LV
R
F
P
AD
F
S
R
KL
D
TFQ
T
A
P
L
Q
L
-
-
I
L
DG
RNS
N
S
A
Q
I
AA
N
Y
L
Q
Q
I
VKNYQ
Q
ELLE
G
KPK
P
N
NSE
L
V
V
--
--
R
N
W
YNPNLD
YK
WF
V
VP
S
L
IA
M
I
--
T
T
I
GVM
I
V
T
S
LSV
A
RERE
Q
GT
L
DQ
LLV
S
P
L
T
TW
Q
I
F
I
GK
-
---
A
V
P
A
L
I
V
AT
F
QAT
I
V
LAIGIW
A
Y
QI
P
FA
GS
XA
LF
Y
F
TMV
I
Y
GLSL
V
G
F
GLLIS
S
LCS
T
Q
Q
QA
FI
GV
F
V
F
-
M
M
PA
IL
LSG
YVS
PVE
N
MP
---
V
W
L
Q
N
LTWIN
P
I
R
HF
TD
I
T
K
Q
I
YL
K
D
A
S
L
D
IVW
NS
L
W
PLL
V
I
TATTGSA
AY
AM
FR
RKV
M
fig|155864.8.peg.890
Escherichia coli O157:H7 EDL933
MFHRL
WT
L
I
RKEL
Q
SLLR
E
P
QTRAILILPV
L
I
Q
V
I
L
F
P
F
AA
T
L
---------
E
V
T
NA
T
IAI
Y
D
E
D
N
GEH
S
VEL
T
QR
F
A
R
ASA
F
THV
L
L
L
K
S
P
Q
E
I
R
PT
I
D
TQ
KA
L
L
LV
R
F
P
AD
F
S
R
KL
D
TFQ
T
A
P
L
Q
L
-
-
I
L
DG
RNS
N
S
A
Q
I
AA
N
Y
L
Q
Q
I
VKNYQ
Q
ELLE
G
KPK
P
N
NSE
L
V
V
--
--
R
N
W
YNPNLD
YK
WF
V
VP
S
L
IA
M
I
--
T
T
I
GVM
I
V
T
S
LSV
A
RERE
Q
GT
L
DQ
LLV
S
P
L
T
TW
Q
I
F
I
GK
-
---
A
V
P
A
L
I
V
AT
F
QAT
I
V
LAIGIW
A
Y
QI
P
FA
GS
XA
LF
Y
F
TMV
I
Y
GLSL
V
G
F
GLLIS
S
LCS
T
Q
Q
QA
FI
GV
F
V
F
-
M
M
PA
IL
LSG
YVS
PVE
N
MP
---
V
W
L
Q
N
LTWIN
P
I
R
HF
TD
I
T
K
Q
I
YL
K
D
A
S
L
D
IVW
NS
L
W
PLL
V
I
TATTGSA
AY
AM
FR
RKV
M
fig|562.376.peg.4814
Escherichia coli WV_060327
MFHRL
WT
L
I
RKEL
Q
SLLR
E
P
QTRAILILPV
L
I
Q
V
I
L
F
P
F
AA
T
L
---------
E
V
T
NA
T
IAI
Y
D
E
D
N
GEH
S
VEL
T
QR
F
A
R
ASA
F
THV
L
L
L
K
S
P
Q
E
I
R
PT
I
D
TQ
KA
L
L
LV
R
F
P
AD
F
S
R
KL
D
TFQ
T
A
P
L
Q
L
-
-
I
L
DG
RNS
N
S
A
Q
I
AA
N
Y
L
Q
Q
I
VKNYQ
Q
ELLE
G
KPK
P
N
NSE
L
V
V
--
--
R
N
W
YNPNLD
YK
WF
V
VP
S
L
IA
M
I
--
T
T
I
GVM
I
V
T
S
LSV
A
RERE
Q
GT
L
DQ
LLV
S
P
L
T
TW
Q
I
F
I
GK
-
---
A
V
P
A
L
I
V
AT
F
QAT
I
V
LAIGIW
A
Y
QI
P
FA
GS
LA
LF
Y
F
TMV
I
Y
GLSL
V
G
F
GLLIS
S
LCS
T
Q
Q
QA
FI
GV
F
V
F
-
M
M
PA
IL
LSG
YVS
PVE
N
MP
---
M
W
L
Q
N
LTWIN
P
I
R
HF
TD
I
T
K
Q
I
YL
K
D
A
S
L
D
IVW
NS
L
W
PLL
V
I
TATTGSA
AY
AM
FR
RKV
M
fig|525281.3.peg.2162
Escherichia coli 83972
MFHRL
WT
L
I
RKEL
Q
SLLR
E
P
QTRAILILPV
L
I
Q
V
I
L
F
P
F
AA
T
L
---------
E
V
T
NA
T
IAI
Y
D
E
D
N
GEH
S
VEL
T
QR
F
A
R
ASA
F
THV
L
L
L
K
S
P
Q
E
I
R
PT
I
D
TQ
KA
L
L
LV
R
F
P
AD
F
S
R
KL
D
TFQ
T
A
P
L
Q
L
-
-
I
L
DG
RNS
N
S
A
Q
I
AA
N
Y
L
Q
Q
I
VKNYQ
Q
ELLE
G
KPK
P
N
NSE
L
V
V
--
--
R
N
W
YNPNLD
YK
WF
V
VP
S
L
IA
M
I
--
T
T
I
GVM
I
V
T
S
LSV
A
RERE
Q
GT
L
DQ
LLV
S
P
L
T
TW
Q
I
F
I
GK
-
---
A
V
P
A
L
I
V
AT
F
QAT
I
V
LAIGIW
A
Y
QI
P
FA
GS
LA
LF
Y
F
TMV
V
Y
GLSL
V
G
F
GLLIS
S
LCS
T
Q
Q
QA
FI
GV
F
V
F
-
M
M
PA
IL
LSG
YVS
PVE
N
MP
---
M
W
L
Q
N
LTWIN
P
I
R
HF
TD
I
T
K
Q
I
YL
K
D
A
S
L
D
IVW
NS
L
W
PLL
V
I
TATTGSA
AY
AM
FR
RKV
M
fig|655817.3.peg.876
Escherichia coli ABU 83972
MFHRL
WT
L
I
RKEL
Q
SLLR
E
P
QTRAILILPV
L
I
Q
V
I
L
F
P
F
AA
T
L
---------
E
V
T
NA
T
IAI
Y
D
E
D
N
GEH
S
VEL
T
QR
F
A
R
ASA
F
THV
L
L
L
K
S
P
Q
E
I
R
PT
I
D
TQ
KA
L
L
LV
R
F
P
AD
F
S
R
KL
D
TFQ
T
A
P
L
Q
L
-
-
I
L
DG
RNS
N
S
A
Q
I
AA
N
Y
L
Q
Q
I
VKNYQ
Q
ELLE
G
KPK
P
N
NSE
L
V
V
--
--
R
N
W
YNPNLD
YK
WF
V
VP
S
L
IA
M
I
--
T
T
I
GVM
I
V
T
S
LSV
A
RERE
Q
GT
L
DQ
LLV
S
P
L
T
TW
Q
I
F
I
GK
-
---
A
V
P
A
L
I
V
AT
F
QAT
I
V
LAIGIW
A
Y
QI
P
FA
GS
LA
LF
Y
F
TMV
V
Y
GLSL
V
G
F
GLLIS
S
LCS
T
Q
Q
QA
FI
GV
F
V
F
-
M
M
PA
IL
LSG
YVS
PVE
N
MP
---
M
W
L
Q
N
LTWIN
P
I
R
HF
TD
I
T
K
Q
I
YL
K
D
A
S
L
D
IVW
NS
L
W
PLL
V
I
TATTGSA
AY
AM
FR
RKV
M
fig|199310.1.peg.848
Escherichia coli CFT073
MFHRL
WT
L
I
RKEL
Q
SLLR
E
P
QTRAILILPV
L
I
Q
V
I
L
F
P
F
AA
T
L
---------
E
V
T
NA
T
IAI
Y
D
E
D
N
GEH
S
VEL
T
QR
F
A
R
ASA
F
THV
L
L
L
K
S
P
Q
E
I
R
PT
I
D
TQ
KA
L
L
LV
R
F
P
AD
F
S
R
KL
D
TFQ
T
A
P
L
Q
L
-
-
I
L
DG
RNS
N
S
A
Q
I
AA
N
Y
L
Q
Q
I
VKNYQ
Q
ELLE
G
KPK
P
N
NSE
L
V
V
--
--
R
N
W
YNPNLD
YK
WF
V
VP
S
L
IA
M
I
--
T
T
I
GVM
I
V
T
S
LSV
A
RERE
Q
GT
L
DQ
LLV
S
P
L
T
TW
Q
I
F
I
GK
-
---
A
V
P
A
L
I
V
AT
F
QAT
I
V
LAIGIW
A
Y
QI
P
FA
GS
LA
LF
Y
F
TMV
V
Y
GLSL
V
G
F
GLLIS
S
LCS
T
Q
Q
QA
FI
GV
F
V
F
-
M
M
PA
IL
LSG
YVS
PVE
N
MP
---
M
W
L
Q
N
LTWIN
P
I
R
HF
TD
I
T
K
Q
I
YL
K
D
A
S
L
D
IVW
NS
L
W
PLL
V
I
TATTGSA
AY
AM
FR
RKV
M
fig|199310.4.peg.830
Escherichia coli CFT073
MFHRL
WT
L
I
RKEL
Q
SLLR
E
P
QTRAILILPV
L
I
Q
V
I
L
F
P
F
AA
T
L
---------
E
V
T
NA
T
IAI
Y
D
E
D
N
GEH
S
VEL
T
QR
F
A
R
ASA
F
THV
L
L
L
K
S
P
Q
E
I
R
PT
I
D
TQ
KA
L
L
LV
R
F
P
AD
F
S
R
KL
D
TFQ
T
A
P
L
Q
L
-
-
I
L
DG
RNS
N
S
A
Q
I
AA
N
Y
L
Q
Q
I
VKNYQ
Q
ELLE
G
KPK
P
N
NSE
L
V
V
--
--
R
N
W
YNPNLD
YK
WF
V
VP
S
L
IA
M
I
--
T
T
I
GVM
I
V
T
S
LSV
A
RERE
Q
GT
L
DQ
LLV
S
P
L
T
TW
Q
I
F
I
GK
-
---
A
V
P
A
L
I
V
AT
F
QAT
I
V
LAIGIW
A
Y
QI
P
FA
GS
LA
LF
Y
F
TMV
V
Y
GLSL
V
G
F
GLLIS
S
LCS
T
Q
Q
QA
FI
GV
F
V
F
-
M
M
PA
IL
LSG
YVS
PVE
N
MP
---
M
W
L
Q
N
LTWIN
P
I
R
HF
TD
I
T
K
Q
I
YL
K
D
A
S
L
D
IVW
NS
L
W
PLL
V
I
TATTGSA
AY
AM
FR
RKV
M
fig|749546.3.peg.4971
Escherichia coli MS 185-1
MFHRL
WT
L
I
RKEL
Q
SLLR
E
P
QTRAILILPV
L
I
Q
V
I
L
F
P
F
AA
T
L
---------
E
V
T
NA
T
IAI
Y
D
E
D
N
GEH
S
VEL
T
QR
F
A
R
ASA
F
THV
L
L
L
K
S
P
Q
E
I
R
PT
I
D
TQ
KA
L
L
LV
R
F
P
AD
F
S
R
KL
D
TFQ
T
A
P
L
Q
L
-
-
I
L
DG
RNS
N
S
A
Q
I
AA
N
Y
L
Q
Q
I
VKNYQ
Q
ELLE
G
KPK
P
N
NSE
L
V
V
--
--
R
N
W
YNPNLD
YK
WF
V
VP
S
L
IA
M
I
--
T
T
I
GVM
I
V
T
S
LSV
A
RERE
Q
GT
L
DQ
LLV
S
P
L
T
TW
Q
I
F
I
GK
-
---
A
V
P
A
L
I
V
AT
F
QAT
I
V
LAIGIW
A
Y
QI
P
FA
GS
LA
LF
Y
F
TMV
V
Y
GLSL
V
G
F
GLLIS
S
LCS
T
Q
Q
QA
FI
GV
F
V
F
-
M
M
PA
IL
LSG
YVS
PVE
N
MP
---
M
W
L
Q
N
LTWIN
P
I
R
HF
TD
I
T
K
Q
I
YL
K
D
A
S
L
D
IVW
NS
L
W
PLL
V
I
TATTGSA
AY
AM
FR
RKV
M
fig|749528.3.peg.4529
Escherichia coli MS 45-1
MFHRL
WT
L
I
RKEL
Q
SLLR
E
P
QTRAILILPV
L
I
Q
V
I
L
F
P
F
AA
T
L
---------
E
V
T
NA
T
IAI
Y
D
E
D
N
GEH
S
VEL
T
QR
F
A
R
ASA
F
THV
L
L
L
K
S
P
Q
E
I
R
PT
I
D
TQ
KA
L
L
LV
R
F
P
AD
F
S
R
KL
D
TFQ
T
A
P
L
Q
L
-
-
I
L
DG
RNS
N
S
A
Q
I
AA
N
Y
L
Q
Q
I
VKNYQ
Q
ELLE
G
KPK
P
N
NSE
L
V
V
--
--
R
N
W
YNPNLD
YK
WF
V
VP
S
L
IA
M
I
--
T
T
I
GVM
I
V
T
S
LSV
A
RERE
Q
GT
L
DQ
LLV
S
P
L
T
TW
Q
I
F
I
GK
-
---
A
V
P
A
L
I
V
AT
F
QAT
I
V
LAIGIW
A
Y
QI
P
FA
GS
LA
LF
Y
F
TMV
V
Y
GLSL
V
G
F
GLLIS
S
LCS
T
Q
Q
QA
FI
GV
F
V
F
-
M
M
PA
IL
LSG
YVS
PVE
N
MP
---
M
W
L
Q
N
LTWIN
P
I
R
HF
TD
I
T
K
Q
I
YL
K
D
A
S
L
D
IVW
NS
L
W
PLL
V
I
TATTGSA
AY
AM
FR
RKV
M
fig|331111.12.peg.1150
Escherichia coli E24377A
MFH
C
L
WT
L
I
RKEL
Q
SLLR
E
P
QTRAILILPV
L
I
Q
V
I
L
F
P
F
AA
T
L
---------
E
V
T
NA
T
IAI
Y
D
E
D
N
GEH
S
VEL
T
QR
F
A
R
ASA
F
THV
L
L
L
K
S
P
Q
E
I
R
PT
I
D
TQ
KA
L
L
LV
R
F
P
AD
F
S
R
KL
D
TFQ
T
A
P
L
Q
L
-
-
I
L
DG
RNS
N
S
A
Q
I
AA
N
Y
L
Q
Q
I
VKNYQ
Q
ELLE
G
KPK
P
N
NSE
L
V
V
--
--
R
N
W
YNPNLD
YK
WF
V
VP
S
L
IA
M
I
--
T
T
I
GVM
I
V
T
S
LSV
A
RERE
Q
GT
L
DQ
LLV
S
P
L
T
TW
Q
I
F
I
GK
-
---
A
V
P
A
L
I
V
AT
F
QAT
I
V
LAIGIW
A
Y
QI
P
FA
GS
LA
LF
Y
F
TMV
I
Y
GLSL
V
G
F
GLLIS
S
LCS
T
Q
Q
QA
FI
GV
F
V
F
-
M
M
PA
IL
LSG
YVS
PVE
N
MP
---
V
W
L
Q
N
LTWIN
P
I
R
HF
TD
I
T
K
Q
I
YL
K
D
A
S
L
D
IVW
NS
L
W
PLL
V
I
TATTGSA
AY
AM
FR
RKV
M
fig|331111.3.peg.3359
Escherichia coli E24377A
MFH
C
L
WT
L
I
RKEL
Q
SLLR
E
P
QTRAILILPV
L
I
Q
V
I
L
F
P
F
AA
T
L
---------
E
V
T
NA
T
IAI
Y
D
E
D
N
GEH
S
VEL
T
QR
F
A
R
ASA
F
THV
L
L
L
K
S
P
Q
E
I
R
PT
I
D
TQ
KA
L
L
LV
R
F
P
AD
F
S
R
KL
D
TFQ
T
A
P
L
Q
L
-
-
I
L
DG
RNS
N
S
A
Q
I
AA
N
Y
L
Q
Q
I
VKNYQ
Q
ELLE
G
KPK
P
N
NSE
L
V
V
--
--
R
N
W
YNPNLD
YK
WF
V
VP
S
L
IA
M
I
--
T
T
I
GVM
I
V
T
S
LSV
A
RERE
Q
GT
L
DQ
LLV
S
P
L
T
TW
Q
I
F
I
GK
-
---
A
V
P
A
L
I
V
AT
F
QAT
I
V
LAIGIW
A
Y
QI
P
FA
GS
LA
LF
Y
F
TMV
I
Y
GLSL
V
G
F
GLLIS
S
LCS
T
Q
Q
QA
FI
GV
F
V
F
-
M
M
PA
IL
LSG
YVS
PVE
N
MP
---
V
W
L
Q
N
LTWIN
P
I
R
HF
TD
I
T
K
Q
I
YL
K
D
A
S
L
D
IVW
NS
L
W
PLL
V
I
TATTGSA
AY
AM
FR
RKV
M
fig|585397.7.peg.764
Escherichia coli ED1a
MFHRL
WT
L
I
RKEL
Q
SLLR
E
P
QTRAILILPV
L
I
Q
V
I
L
F
P
F
AA
T
L
---------
E
V
T
NA
T
IAI
Y
D
E
D
N
GEH
S
VEL
T
QR
F
A
R
ASA
F
THV
L
L
L
K
S
P
Q
E
I
R
PT
I
D
TQ
KT
L
L
LV
R
F
P
AD
F
S
R
KL
D
TFQ
T
A
P
L
Q
L
-
-
I
L
DG
RNS
N
S
A
Q
I
AA
N
Y
L
Q
Q
I
VKNYQ
Q
ELLE
G
KPK
P
N
NSE
L
V
V
--
--
R
N
W
YNPNLD
YK
WF
V
VP
S
L
IA
M
I
--
T
T
I
GVM
I
V
T
S
LSV
A
RERE
Q
GT
L
DQ
LLV
S
P
L
T
TW
Q
I
F
I
GK
-
---
A
V
P
A
L
I
V
AT
F
QAT
I
V
LAIGIW
A
Y
QI
P
FA
GS
LA
LF
Y
F
TMV
I
Y
GLSL
V
G
F
GLLIS
S
LCS
T
Q
Q
QA
FI
GV
F
V
F
-
M
M
PA
IL
LSG
YVS
PVE
N
MP
---
M
W
L
Q
N
LTWIN
P
I
R
HF
TD
I
T
K
Q
I
YL
K
D
A
S
L
D
IVW
NS
L
W
PLL
V
I
TATTGSA
AY
AM
FR
RKV
M
fig|585397.9.peg.764
Escherichia coli ED1a
MFHRL
WT
L
I
RKEL
Q
SLLR
E
P
QTRAILILPV
L
I
Q
V
I
L
F
P
F
AA
T
L
---------
E
V
T
NA
T
IAI
Y
D
E
D
N
GEH
S
VEL
T
QR
F
A
R
ASA
F
THV
L
L
L
K
S
P
Q
E
I
R
PT
I
D
TQ
KT
L
L
LV
R
F
P
AD
F
S
R
KL
D
TFQ
T
A
P
L
Q
L
-
-
I
L
DG
RNS
N
S
A
Q
I
AA
N
Y
L
Q
Q
I
VKNYQ
Q
ELLE
G
KPK
P
N
NSE
L
V
V
--
--
R
N
W
YNPNLD
YK
WF
V
VP
S
L
IA
M
I
--
T
T
I
GVM
I
V
T
S
LSV
A
RERE
Q
GT
L
DQ
LLV
S
P
L
T
TW
Q
I
F
I
GK
-
---
A
V
P
A
L
I
V
AT
F
QAT
I
V
LAIGIW
A
Y
QI
P
FA
GS
LA
LF
Y
F
TMV
I
Y
GLSL
V
G
F
GLLIS
S
LCS
T
Q
Q
QA
FI
GV
F
V
F
-
M
M
PA
IL
LSG
YVS
PVE
N
MP
---
M
W
L
Q
N
LTWIN
P
I
R
HF
TD
I
T
K
Q
I
YL
K
D
A
S
L
D
IVW
NS
L
W
PLL
V
I
TATTGSA
AY
AM
FR
RKV
M
fig|550676.3.peg.253
Escherichia coli B185
MFHRL
WT
L
I
RKEL
Q
SLLR
E
P
QTRAILILPV
L
I
Q
V
I
L
F
P
F
AA
T
L
---------
E
V
T
NA
T
IAI
Y
D
E
D
N
GEH
S
VEL
T
QR
F
A
R
ASA
F
THV
L
L
L
K
S
P
Q
E
I
R
PT
I
D
TQ
KA
L
L
LV
R
F
P
AD
F
S
R
KL
D
TYQ
T
V
P
L
Q
L
-
-
I
L
DG
RNS
N
S
A
Q
I
AA
N
Y
L
Q
Q
I
VKNYQ
Q
ELLE
G
KPK
P
N
NSE
L
V
V
--
--
R
N
W
YNPNLD
YK
WF
V
VP
S
L
IA
M
I
--
T
T
I
GVM
I
V
T
S
LSV
A
RERE
Q
GT
L
DQ
LLV
S
P
L
T
TW
Q
I
F
I
GK
-
---
A
V
P
A
L
I
V
AT
F
QAT
I
V
LAIGIW
A
Y
QI
P
FA
GS
LA
LF
Y
F
TMV
I
Y
GLSL
V
G
F
GLLIS
S
LCS
T
Q
Q
QA
FI
GV
F
V
F
-
M
M
PA
IL
LSG
YVS
PVE
N
MP
---
V
W
L
Q
N
LTWIN
P
I
R
HF
TD
I
T
K
Q
I
YL
K
D
A
S
L
D
IVW
NS
L
W
PLL
V
I
TATTGSA
AY
AM
FR
RKV
M
fig|585057.4.peg.815
Escherichia coli IAI39
MFHRL
WT
L
I
RKEL
Q
SLLR
E
P
QTRAILILPV
L
I
Q
V
I
L
F
P
F
AA
T
L
---------
E
V
T
NA
T
IAI
Y
D
E
D
N
GEH
S
VEL
T
QR
F
A
R
ASA
F
THV
L
L
L
K
S
P
Q
E
I
R
PT
I
D
TQ
KA
L
L
LV
R
F
P
AD
F
S
R
KL
D
TFQ
T
A
P
L
Q
L
-
-
I
L
DG
RNS
N
S
A
Q
I
AA
N
Y
L
Q
Q
I
VKNYQ
L
ELLE
G
KPK
P
N
NSE
L
V
V
--
--
R
N
W
YNPNLD
YK
WF
V
VP
S
L
IA
M
I
--
T
T
I
GVM
I
V
T
S
LSV
A
RERE
Q
GT
L
DQ
LLV
S
P
L
T
TW
Q
I
F
I
GK
-
---
A
V
P
A
L
I
V
AT
F
QAT
I
V
LAIGIW
A
Y
QI
P
FA
GS
LA
LF
Y
F
TMV
I
Y
GLSL
V
G
F
GLLIS
S
LCS
T
Q
Q
QA
FI
GV
F
V
F
-
M
M
PA
IL
LSG
YVS
PVE
N
MP
---
V
W
L
Q
N
LTWIN
P
I
R
HF
TD
I
T
K
Q
I
YL
K
D
A
S
L
D
IVW
NS
L
W
PLL
V
I
TATTGSA
AY
AM
FR
RKV
M
fig|585057.6.peg.812
Escherichia coli IAI39
MFHRL
WT
L
I
RKEL
Q
SLLR
E
P
QTRAILILPV
L
I
Q
V
I
L
F
P
F
AA
T
L
---------
E
V
T
NA
T
IAI
Y
D
E
D
N
GEH
S
VEL
T
QR
F
A
R
ASA
F
THV
L
L
L
K
S
P
Q
E
I
R
PT
I
D
TQ
KA
L
L
LV
R
F
P
AD
F
S
R
KL
D
TFQ
T
A
P
L
Q
L
-
-
I
L
DG
RNS
N
S
A
Q
I
AA
N
Y
L
Q
Q
I
VKNYQ
L
ELLE
G
KPK
P
N
NSE
L
V
V
--
--
R
N
W
YNPNLD
YK
WF
V
VP
S
L
IA
M
I
--
T
T
I
GVM
I
V
T
S
LSV
A
RERE
Q
GT
L
DQ
LLV
S
P
L
T
TW
Q
I
F
I
GK
-
---
A
V
P
A
L
I
V
AT
F
QAT
I
V
LAIGIW
A
Y
QI
P
FA
GS
LA
LF
Y
F
TMV
I
Y
GLSL
V
G
F
GLLIS
S
LCS
T
Q
Q
QA
FI
GV
F
V
F
-
M
M
PA
IL
LSG
YVS
PVE
N
MP
---
V
W
L
Q
N
LTWIN
P
I
R
HF
TD
I
T
K
Q
I
YL
K
D
A
S
L
D
IVW
NS
L
W
PLL
V
I
TATTGSA
AY
AM
FR
RKV
M
fig|656414.3.peg.989
Escherichia coli H736
MFHRL
WT
L
I
RKEL
Q
SLLR
E
P
QTRAILILPV
L
I
Q
V
I
L
F
P
F
AA
T
L
---------
E
V
T
NA
T
IAI
Y
D
E
D
N
GEH
S
VEL
T
QR
F
A
R
ASA
F
THV
L
L
L
K
S
P
Q
E
I
R
PT
I
D
TQ
KA
L
L
LV
R
F
P
AD
F
S
R
KL
D
TFQ
T
A
P
L
Q
L
-
-
I
L
DG
RNS
N
S
A
Q
I
AA
N
Y
L
Q
Q
I
VKNYQ
Q
ELLE
G
KPK
P
N
NSE
L
V
V
--
--
R
N
W
YN
L
NLD
YK
WF
V
VP
S
L
IA
M
I
--
T
T
I
GVM
I
V
T
S
LSV
A
RERE
Q
GT
L
DQ
LLV
S
P
L
T
TW
Q
I
F
I
GK
-
---
A
V
P
A
L
I
V
AT
F
QAT
I
V
LAIGIW
A
Y
QI
P
FA
GS
LA
LF
Y
F
TMV
I
Y
GLSL
V
G
F
GLLIS
S
LCS
T
Q
Q
QA
FI
GV
F
V
F
-
M
M
PA
IL
LSG
YVS
PVE
N
MP
---
V
W
L
Q
N
LTWIN
P
I
R
HF
TD
I
T
K
Q
I
YL
K
D
A
S
L
D
IVW
NS
L
W
PLL
V
I
TATTGSA
AY
AM
FR
RKV
M
fig|679205.4.peg.4434
Escherichia coli MS 124-1 (540-893/911)
LR
RLFS
Y
SR
R
E
A
L
E
L
R
RDP
VRSTLALMGT
V
I
L
M
L
I
M
G
Y
GI
S
M
---------
D
V
E
N
L
R
F
A
V
L
D
R
DQ
TVS
S
QAW
T
LN
L
S
G
SRY
F
IEQ
P
P
L
T
S
Y
DE
L
D
RR
M
R
AG
DI
T
V
AI
E
IPPNF
G
R
--
D
IAR
G
T
P
V
E
L
G
V
W
I
DG
AMP
S
R
A
E
T
VK
GY
V
Q
A
M
HQSWL
Q
DVAS
R
QST
P
A
SQS
G
L
M
NI
ETR
Y
RYNP
DVK
SL
PA
I
VP
A
VI
P
L
L
--
L
M
M
IPS
M
L
S
A
LSV
V
RE
K
E
L
G
S
I
IN
L
Y
V
T
P
T
T
RS
E
F
L
L
GK
-
---
Q
LP
Y
I
V
L
GM
L
NFF
L
L
CGLSVF
V
F
GVP
HK
GS
FL
TL
T
L
AVL
LY
IIIA
TG
M
GLLIST
FMK
SQ
I
A
A
IF
G
T
A
I
I
T
L
I
PA
TQ
F
SG
MID
PV
A
S
LEGPG
R
W
I
G
E
---VY
PT
S
HF
LT
IA
R
G
T
FS
K
A
L
D
L
T
DL
W
QL
F
I
PLL
I
fig|749533.3.peg.5100
Escherichia coli MS 84-1 (540-893/911)
LR
RLFS
Y
SR
R
E
A
L
E
L
R
RDP
VRSTLALMGT
V
I
L
M
L
I
M
G
Y
GI
S
M
---------
D
V
E
N
L
R
F
A
V
L
D
R
DQ
TVS
S
QAW
T
LN
L
S
G
SRY
F
IEQ
P
P
L
T
S
Y
DE
L
D
RR
M
R
AG
DI
T
V
AI
E
IPPNF
G
R
--
D
IAR
G
T
P
V
E
L
G
V
W
I
DG
AMP
S
R
A
E
T
VK
GY
V
Q
A
M
HQSWL
Q
DVAS
R
QST
P
A
SQS
G
L
M
NI
ETR
Y
RYNP
DVK
SL
PA
I
VP
A
VI
P
L
L
--
L
M
M
IPS
M
L
S
A
LSV
V
RE
K
E
L
G
S
I
IN
L
Y
V
T
P
T
T
RS
E
F
L
L
GK
-
---
Q
LP
Y
I
V
L
GM
L
NFF
L
L
CGLSVF
V
F
GVP
HK
GS
FL
TL
T
L
AVL
LY
IIIA
TG
M
GLLIST
FMK
SQ
I
A
A
IF
G
T
A
I
I
T
L
I
PA
TQ
F
SG
MID
PV
A
S
LEGPG
R
W
I
G
E
---VY
PT
S
HF
LT
IA
R
G
T
FS
K
A
L
D
L
T
DL
W
QL
F
I
PLL
I
fig|562.371.peg.3345
Escherichia coli 1044A (540-893/911)
LR
RLFS
Y
SR
R
E
A
L
E
L
R
RDP
VRSTLALMGT
V
I
L
M
L
I
M
G
Y
GI
S
M
---------
D
V
E
N
L
R
F
A
V
L
D
R
DQ
TVS
S
QAW
T
LN
L
S
G
SRY
F
IEQ
P
L
L
T
S
Y
DE
L
D
RR
M
R
AG
DI
T
V
AI
E
IPPNF
G
R
--
D
IAR
G
T
P
V
E
L
G
V
W
I
DG
AMP
S
R
A
E
T
VK
GY
V
Q
A
M
HQSWL
Q
DVAS
R
QST
P
S
SQS
G
L
M
NI
ETR
Y
RYNP
DVK
SL
PA
I
VP
A
VI
P
L
L
--
L
M
M
IPS
M
L
S
A
LSV
V
RE
K
E
L
G
S
I
IN
L
Y
V
T
P
T
T
RS
E
F
L
L
GK
-
---
Q
LP
Y
I
A
L
GM
L
NFF
L
L
CGLSVF
V
F
GVP
HK
GS
FL
TL
T
L
AAL
LY
IIIA
TG
M
GLLIST
FMK
SQ
I
A
A
IF
G
T
A
I
I
T
L
I
PA
TQ
F
SG
MID
PV
A
S
LEGPG
R
W
I
G
E
---VY
PT
S
HF
LT
IA
R
G
T
FS
K
A
L
D
L
T
DL
W
QL
F
I
PLL
I
fig|562.373.peg.1504
Escherichia coli 1125A (540-893/911)
LR
RLFS
Y
SR
R
E
A
L
E
L
R
RDP
VRSTLALMGT
V
I
L
M
L
I
M
G
Y
GI
S
M
---------
D
V
E
N
L
R
F
A
V
L
D
R
DQ
TVS
S
QAW
T
LN
L
S
G
SRY
F
IEQ
P
L
L
T
S
Y
DE
L
D
RR
M
R
AG
DI
T
V
AI
E
IPPNF
G
R
--
D
IAR
G
T
P
V
E
L
G
V
W
I
DG
AMP
S
R
A
E
T
VK
GY
V
Q
A
M
HQSWL
Q
DVAS
R
QST
P
S
SQS
G
L
M
NI
ETR
Y
RYNP
DVK
SL
PA
I
VP
A
VI
P
L
L
--
L
M
M
IPS
M
L
S
A
LSV
V
RE
K
E
L
G
S
I
IN
L
Y
V
T
P
T
T
RS
E
F
L
L
GK
-
---
Q
LP
Y
I
A
L
GM
L
NFF
L
L
CGLSVF
V
F
GVP
HK
GS
FL
TL
T
L
AAL
LY
IIIA
TG
M
GLLIST
FMK
SQ
I
A
A
IF
G
T
A
I
I
T
L
I
PA
TQ
F
SG
MID
PV
A
S
LEGPG
R
W
I
G
E
---VY
PT
S
HF
LT
IA
R
G
T
FS
K
A
L
D
L
T
DL
W
QL
F
I
PLL
I
fig|562.372.peg.4227
Escherichia coli 1212A (540-893/911)
LR
RLFS
Y
SR
R
E
A
L
E
L
R
RDP
VRSTLALMGT
V
I
L
M
L
I
M
G
Y
GI
S
M
---------
D
V
E
N
L
R
F
A
V
L
D
R
DQ
TVS
S
QAW
T
LN
L
S
G
SRY
F
IEQ
P
L
L
T
S
Y
DE
L
D
RR
M
R
AG
DI
T
V
AI
E
IPPNF
G
R
--
D
IAR
G
T
P
V
E
L
G
V
W
I
DG
AMP
S
R
A
E
T
VK
GY
V
Q
A
M
HQSWL
Q
DVAS
R
QST
P
S
SQS
G
L
M
NI
ETR
Y
RYNP
DVK
SL
PA
I
VP
A
VI
P
L
L
--
L
M
M
IPS
M
L
S
A
LSV
V
RE
K
E
L
G
S
I
IN
L
Y
V
T
P
T
T
RS
E
F
L
L
GK
-
---
Q
LP
Y
I
A
L
GM
L
NFF
L
L
CGLSVF
V
F
GVP
HK
GS
FL
TL
T
L
AAL
LY
IIIA
TG
M
GLLIST
FMK
SQ
I
A
A
IF
G
T
A
I
I
T
L
I
PA
TQ
F
SG
MID
PV
A
S
LEGPG
R
W
I
G
E
---VY
PT
S
HF
LT
IA
R
G
T
FS
K
A
L
D
L
T
DL
W
QL
F
I
PLL
I
fig|562.374.peg.5090
Escherichia coli 536A (540-893/911)
LR
RLFS
Y
SR
R
E
A
L
E
L
R
RDP
VRSTLALMGT
V
I
L
M
L
I
M
G
Y
GI
S
M
---------
D
V
E
N
L
R
F
A
V
L
D
R
DQ
TVS
S
QAW
T
LN
L
S
G
SRY
F
IEQ
P
L
L
T
S
Y
DE
L
D
RR
M
R
AG
DI
T
V
AI
E
IPPNF
G
R
--
D
IAR
G
T
P
V
E
L
G
V
W
I
DG
AMP
S
R
A
E
T
VK
GY
V
Q
A
M
HQSWL
Q
DVAS
R
QST
P
S
SQS
G
L
M
NI
ETR
Y
RYNP
DVK
SL
PA
I
VP
A
VI
P
L
L
--
L
M
M
IPS
M
L
S
A
LSV
V
RE
K
E
L
G
S
I
IN
L
Y
V
T
P
T
T
RS
E
F
L
L
GK
-
---
Q
LP
Y
I
A
L
GM
L
NFF
L
L
CGLSVF
V
F
GVP
HK
GS
FL
TL
T
L
AAL
LY
IIIA
TG
M
GLLIST
FMK
SQ
I
A
A
IF
G
T
A
I
I
T
L
I
PA
TQ
F
SG
MID
PV
A
S
LEGPG
R
W
I
G
E
---VY
PT
S
HF
LT
IA
R
G
T
FS
K
A
L
D
L
T
DL
W
QL
F
I
PLL
I
fig|155864.8.peg.4309
Escherichia coli O157:H7 EDL933 (540-893/911)
LR
RLFS
Y
SR
R
E
A
L
E
L
R
RDP
VRSTLALMGT
V
I
L
M
L
I
M
G
Y
GI
S
M
---------
D
V
E
N
L
R
F
A
V
L
D
R
DQ
TVS
S
QAW
T
LN
L
S
G
SRY
F
IEQ
P
L
L
T
S
Y
DE
L
D
RR
M
R
AG
DI
T
V
AI
E
IPPNF
G
R
--
D
IAR
G
T
P
V
E
L
G
V
W
I
DG
AMP
S
R
A
E
T
VK
GY
V
Q
A
M
HQSWL
Q
DVAS
R
QST
P
S
SQS
G
L
M
NI
ETR
Y
RYNP
DVK
SL
PA
I
VP
A
VI
P
L
L
--
L
M
M
IPS
M
L
S
A
LSV
V
RE
K
E
L
G
S
I
IN
L
Y
V
T
P
T
T
RS
E
F
L
L
GK
-
---
Q
LP
Y
I
A
L
GM
L
NFF
L
L
CGLSVF
V
F
GVP
HK
GS
FL
TL
T
L
AAL
LY
IIIA
TG
M
GLLIST
FMK
SQ
I
A
A
IF
G
T
A
I
I
T
L
I
PA
TQ
F
SG
MID
PV
A
S
LEGPG
R
W
I
G
E
---VY
PT
S
HF
LT
IA
R
G
T
FS
K
A
L
D
L
T
DL
W
QL
F
I
PLL
I
fig|444454.5.peg.3438
Escherichia coli O157:H7 str. EC4024 (540-893/911)
LR
RLFS
Y
SR
R
E
A
L
E
L
R
RDP
VRSTLALMGT
V
I
L
M
L
I
M
G
Y
GI
S
M
---------
D
V
E
N
L
R
F
A
V
L
D
R
DQ
TVS
S
QAW
T
LN
L
S
G
SRY
F
IEQ
P
L
L
T
S
Y
DE
L
D
RR
M
R
AG
DI
T
V
AI
E
IPPNF
G
R
--
D
IAR
G
T
P
V
E
L
G
V
W
I
DG
AMP
S
R
A
E
T
VK
GY
V
Q
A
M
HQSWL
Q
DVAS
R
QST
P
S
SQS
G
L
M
NI
ETR
Y
RYNP
DVK
SL
PA
I
VP
A
VI
P
L
L
--
L
M
M
IPS
M
L
S
A
LSV
V
RE
K
E
L
G
S
I
IN
L
Y
V
T
P
T
T
RS
E
F
L
L
GK
-
---
Q
LP
Y
I
A
L
GM
L
NFF
L
L
CGLSVF
V
F
GVP
HK
GS
FL
TL
T
L
AAL
LY
IIIA
TG
M
GLLIST
FMK
SQ
I
A
A
IF
G
T
A
I
I
T
L
I
PA
TQ
F
SG
MID
PV
A
S
LEGPG
R
W
I
G
E
---VY
PT
S
HF
LT
IA
R
G
T
FS
K
A
L
D
L
T
DL
W
QL
F
I
PLL
I
fig|444449.5.peg.2893
Escherichia coli O157:H7 str. EC4042 (540-893/911)
LR
RLFS
Y
SR
R
E
A
L
E
L
R
RDP
VRSTLALMGT
V
I
L
M
L
I
M
G
Y
GI
S
M
---------
D
V
E
N
L
R
F
A
V
L
D
R
DQ
TVS
S
QAW
T
LN
L
S
G
SRY
F
IEQ
P
L
L
T
S
Y
DE
L
D
RR
M
R
AG
DI
T
V
AI
E
IPPNF
G
R
--
D
IAR
G
T
P
V
E
L
G
V
W
I
DG
AMP
S
R
A
E
T
VK
GY
V
Q
A
M
HQSWL
Q
DVAS
R
QST
P
S
SQS
G
L
M
NI
ETR
Y
RYNP
DVK
SL
PA
I
VP
A
VI
P
L
L
--
L
M
M
IPS
M
L
S
A
LSV
V
RE
K
E
L
G
S
I
IN
L
Y
V
T
P
T
T
RS
E
F
L
L
GK
-
---
Q
LP
Y
I
A
L
GM
L
NFF
L
L
CGLSVF
V
F
GVP
HK
GS
FL
TL
T
L
AAL
LY
IIIA
TG
M
GLLIST
FMK
SQ
I
A
A
IF
G
T
A
I
I
T
L
I
PA
TQ
F
SG
MID
PV
A
S
LEGPG
R
W
I
G
E
---VY
PT
S
HF
LT
IA
R
G
T
FS
K
A
L
D
L
T
DL
W
QL
F
I
PLL
I
fig|444448.5.peg.1645
Escherichia coli O157:H7 str. EC4045 (540-893/911)
LR
RLFS
Y
SR
R
E
A
L
E
L
R
RDP
VRSTLALMGT
V
I
L
M
L
I
M
G
Y
GI
S
M
---------
D
V
E
N
L
R
F
A
V
L
D
R
DQ
TVS
S
QAW
T
LN
L
S
G
SRY
F
IEQ
P
L
L
T
S
Y
DE
L
D
RR
M
R
AG
DI
T
V
AI
E
IPPNF
G
R
--
D
IAR
G
T
P
V
E
L
G
V
W
I
DG
AMP
S
R
A
E
T
VK
GY
V
Q
A
M
HQSWL
Q
DVAS
R
QST
P
S
SQS
G
L
M
NI
ETR
Y
RYNP
DVK
SL
PA
I
VP
A
VI
P
L
L
--
L
M
M
IPS
M
L
S
A
LSV
V
RE
K
E
L
G
S
I
IN
L
Y
V
T
P
T
T
RS
E
F
L
L
GK
-
---
Q
LP
Y
I
A
L
GM
L
NFF
L
L
CGLSVF
V
F
GVP
HK
GS
FL
TL
T
L
AAL
LY
IIIA
TG
M
GLLIST
FMK
SQ
I
A
A
IF
G
T
A
I
I
T
L
I
PA
TQ
F
SG
MID
PV
A
S
LEGPG
R
W
I
G
E
---VY
PT
S
HF
LT
IA
R
G
T
FS
K
A
L
D
L
T
DL
W
QL
F
I
PLL
I
fig|444453.5.peg.1177
Escherichia coli O157:H7 str. EC4076 (540-893/911)
LR
RLFS
Y
SR
R
E
A
L
E
L
R
RDP
VRSTLALMGT
V
I
L
M
L
I
M
G
Y
GI
S
M
---------
D
V
E
N
L
R
F
A
V
L
D
R
DQ
TVS
S
QAW
T
LN
L
S
G
SRY
F
IEQ
P
L
L
T
S
Y
DE
L
D
RR
M
R
AG
DI
T
V
AI
E
IPPNF
G
R
--
D
IAR
G
T
P
V
E
L
G
V
W
I
DG
AMP
S
R
A
E
T
VK
GY
V
Q
A
M
HQSWL
Q
DVAS
R
QST
P
S
SQS
G
L
M
NI
ETR
Y
RYNP
DVK
SL
PA
I
VP
A
VI
P
L
L
--
L
M
M
IPS
M
L
S
A
LSV
V
RE
K
E
L
G
S
I
IN
L
Y
V
T
P
T
T
RS
E
F
L
L
GK
-
---
Q
LP
Y
I
A
L
GM
L
NFF
L
L
CGLSVF
V
F
GVP
HK
GS
FL
TL
T
L
AAL
LY
IIIA
TG
M
GLLIST
FMK
SQ
I
A
A
IF
G
T
A
I
I
T
L
I
PA
TQ
F
SG
MID
PV
A
S
LEGPG
R
W
I
G
E
---VY
PT
S
HF
LT
IA
R
G
T
FS
K
A
L
D
L
T
DL
W
QL
F
I
PLL
I
fig|444452.5.peg.165
Escherichia coli O157:H7 str. EC4113 (540-893/911)
LR
RLFS
Y
SR
R
E
A
L
E
L
R
RDP
VRSTLALMGT
V
I
L
M
L
I
M
G
Y
GI
S
M
---------
D
V
E
N
L
R
F
A
V
L
D
R
DQ
TVS
S
QAW
T
LN
L
S
G
SRY
F
IEQ
P
L
L
T
S
Y
DE
L
D
RR
M
R
AG
DI
T
V
AI
E
IPPNF
G
R
--
D
IAR
G
T
P
V
E
L
G
V
W
I
DG
AMP
S
R
A
E
T
VK
GY
V
Q
A
M
HQSWL
Q
DVAS
R
QST
P
S
SQS
G
L
M
NI
ETR
Y
RYNP
DVK
SL
PA
I
VP
A
VI
P
L
L
--
L
M
M
IPS
M
L
S
A
LSV
V
RE
K
E
L
G
S
I
IN
L
Y
V
T
P
T
T
RS
E
F
L
L
GK
-
---
Q
LP
Y
I
A
L
GM
L
NFF
L
L
CGLSVF
V
F
GVP
HK
GS
FL
TL
T
L
AAL
LY
IIIA
TG
M
GLLIST
FMK
SQ
I
A
A
IF
G
T
A
I
I
T
L
I
PA
TQ
F
SG
MID
PV
A
S
LEGPG
R
W
I
G
E
---VY
PT
S
HF
LT
IA
R
G
T
FS
K
A
L
D
L
T
DL
W
QL
F
I
PLL
I
fig|444450.8.peg.4727
Escherichia coli O157:H7 str. EC4115 (540-893/911)
LR
RLFS
Y
SR
R
E
A
L
E
L
R
RDP
VRSTLALMGT
V
I
L
M
L
I
M
G
Y
GI
S
M
---------
D
V
E
N
L
R
F
A
V
L
D
R
DQ
TVS
S
QAW
T
LN
L
S
G
SRY
F
IEQ
P
L
L
T
S
Y
DE
L
D
RR
M
R
AG
DI
T
V
AI
E
IPPNF
G
R
--
D
IAR
G
T
P
V
E
L
G
V
W
I
DG
AMP
S
R
A
E
T
VK
GY
V
Q
A
M
HQSWL
Q
DVAS
R
QST
P
S
SQS
G
L
M
NI
ETR
Y
RYNP
DVK
SL
PA
I
VP
A
VI
P
L
L
--
L
M
M
IPS
M
L
S
A
LSV
V
RE
K
E
L
G
S
I
IN
L
Y
V
T
P
T
T
RS
E
F
L
L
GK
-
---
Q
LP
Y
I
A
L
GM
L
NFF
L
L
CGLSVF
V
F
GVP
HK
GS
FL
TL
T
L
AAL
LY
IIIA
TG
M
GLLIST
FMK
SQ
I
A
A
IF
G
T
A
I
I
T
L
I
PA
TQ
F
SG
MID
PV
A
S
LEGPG
R
W
I
G
E
---VY
PT
S
HF
LT
IA
R
G
T
FS
K
A
L
D
L
T
DL
W
QL
F
I
PLL
I
fig|444451.5.peg.339
Escherichia coli O157:H7 str. EC4196 (540-893/911)
LR
RLFS
Y
SR
R
E
A
L
E
L
R
RDP
VRSTLALMGT
V
I
L
M
L
I
M
G
Y
GI
S
M
---------
D
V
E
N
L
R
F
A
V
L
D
R
DQ
TVS
S
QAW
T
LN
L
S
G
SRY
F
IEQ
P
L
L
T
S
Y
DE
L
D
RR
M
R
AG
DI
T
V
AI
E
IPPNF
G
R
--
D
IAR
G
T
P
V
E
L
G
V
W
I
DG
AMP
S
R
A
E
T
VK
GY
V
Q
A
M
HQSWL
Q
DVAS
R
QST
P
S
SQS
G
L
M
NI
ETR
Y
RYNP
DVK
SL
PA
I
VP
A
VI
P
L
L
--
L
M
M
IPS
M
L
S
A
LSV
V
RE
K
E
L
G
S
I
IN
L
Y
V
T
P
T
T
RS
E
F
L
L
GK
-
---
Q
LP
Y
I
A
L
GM
L
NFF
L
L
CGLSVF
V
F
GVP
HK
GS
FL
TL
T
L
AAL
LY
IIIA
TG
M
GLLIST
FMK
SQ
I
A
A
IF
G
T
A
I
I
T
L
I
PA
TQ
F
SG
MID
PV
A
S
LEGPG
R
W
I
G
E
---VY
PT
S
HF
LT
IA
R
G
T
FS
K
A
L
D
L
T
DL
W
QL
F
I
PLL
I
fig|444447.5.peg.1808
Escherichia coli O157:H7 str. EC4206 (540-893/911)
LR
RLFS
Y
SR
R
E
A
L
E
L
R
RDP
VRSTLALMGT
V
I
L
M
L
I
M
G
Y
GI
S
M
---------
D
V
E
N
L
R
F
A
V
L
D
R
DQ
TVS
S
QAW
T
LN
L
S
G
SRY
F
IEQ
P
L
L
T
S
Y
DE
L
D
RR
M
R
AG
DI
T
V
AI
E
IPPNF
G
R
--
D
IAR
G
T
P
V
E
L
G
V
W
I
DG
AMP
S
R
A
E
T
VK
GY
V
Q
A
M
HQSWL
Q
DVAS
R
QST
P
S
SQS
G
L
M
NI
ETR
Y
RYNP
DVK
SL
PA
I
VP
A
VI
P
L
L
--
L
M
M
IPS
M
L
S
A
LSV
V
RE
K
E
L
G
S
I
IN
L
Y
V
T
P
T
T
RS
E
F
L
L
GK
-
---
Q
LP
Y
I
A
L
GM
L
NFF
L
L
CGLSVF
V
F
GVP
HK
GS
FL
TL
T
L
AAL
LY
IIIA
TG
M
GLLIST
FMK
SQ
I
A
A
IF
G
T
A
I
I
T
L
I
PA
TQ
F
SG
MID
PV
A
S
LEGPG
R
W
I
G
E
---VY
PT
S
HF
LT
IA
R
G
T
FS
K
A
L
D
L
T
DL
W
QL
F
I
PLL
I
fig|478004.5.peg.203
Escherichia coli O157:H7 str. EC4401 (540-893/911)
LR
RLFS
Y
SR
R
E
A
L
E
L
R
RDP
VRSTLALMGT
V
I
L
M
L
I
M
G
Y
GI
S
M
---------
D
V
E
N
L
R
F
A
V
L
D
R
DQ
TVS
S
QAW
T
LN
L
S
G
SRY
F
IEQ
P
L
L
T
S
Y
DE
L
D
RR
M
R
AG
DI
T
V
AI
E
IPPNF
G
R
--
D
IAR
G
T
P
V
E
L
G
V
W
I
DG
AMP
S
R
A
E
T
VK
GY
V
Q
A
M
HQSWL
Q
DVAS
R
QST
P
S
SQS
G
L
M
NI
ETR
Y
RYNP
DVK
SL
PA
I
VP
A
VI
P
L
L
--
L
M
M
IPS
M
L
S
A
LSV
V
RE
K
E
L
G
S
I
IN
L
Y
V
T
P
T
T
RS
E
F
L
L
GK
-
---
Q
LP
Y
I
A
L
GM
L
NFF
L
L
CGLSVF
V
F
GVP
HK
GS
FL
TL
T
L
AAL
LY
IIIA
TG
M
GLLIST
FMK
SQ
I
A
A
IF
G
T
A
I
I
T
L
I
PA
TQ
F
SG
MID
PV
A
S
LEGPG
R
W
I
G
E
---VY
PT
S
HF
LT
IA
R
G
T
FS
K
A
L
D
L
T
DL
W
QL
F
I
PLL
I
fig|478005.5.peg.165
Escherichia coli O157:H7 str. EC4486 (540-893/911)
LR
RLFS
Y
SR
R
E
A
L
E
L
R
RDP
VRSTLALMGT
V
I
L
M
L
I
M
G
Y
GI
S
M
---------
D
V
E
N
L
R
F
A
V
L
D
R
DQ
TVS
S
QAW
T
LN
L
S
G
SRY
F
IEQ
P
L
L
T
S
Y
DE
L
D
RR
M
R
AG
DI
T
V
AI
E
IPPNF
G
R
--
D
IAR
G
T
P
V
E
L
G
V
W
I
DG
AMP
S
R
A
E
T
VK
GY
V
Q
A
M
HQSWL
Q
DVAS
R
QST
P
S
SQS
G
L
M
NI
ETR
Y
RYNP
DVK
SL
PA
I
VP
A
VI
P
L
L
--
L
M
M
IPS
M
L
S
A
LSV
V
RE
K
E
L
G
S
I
IN
L
Y
V
T
P
T
T
RS
E
F
L
L
GK
-
---
Q
LP
Y
I
A
L
GM
L
NFF
L
L
CGLSVF
V
F
GVP
HK
GS
FL
TL
T
L
AAL
LY
IIIA
TG
M
GLLIST
FMK
SQ
I
A
A
IF
G
T
A
I
I
T
L
I
PA
TQ
F
SG
MID
PV
A
S
LEGPG
R
W
I
G
E
---VY
PT
S
HF
LT
IA
R
G
T
FS
K
A
L
D
L
T
DL
W
QL
F
I
PLL
I
fig|478006.5.peg.168
Escherichia coli O157:H7 str. EC4501 (540-893/911)
LR
RLFS
Y
SR
R
E
A
L
E
L
R
RDP
VRSTLALMGT
V
I
L
M
L
I
M
G
Y
GI
S
M
---------
D
V
E
N
L
R
F
A
V
L
D
R
DQ
TVS
S
QAW
T
LN
L
S
G
SRY
F
IEQ
P
L
L
T
S
Y
DE
L
D
RR
M
R
AG
DI
T
V
AI
E
IPPNF
G
R
--
D
IAR
G
T
P
V
E
L
G
V
W
I
DG
AMP
S
R
A
E
T
VK
GY
V
Q
A
M
HQSWL
Q
DVAS
R
QST
P
S
SQS
G
L
M
NI
ETR
Y
RYNP
DVK
SL
PA
I
VP
A
VI
P
L
L
--
L
M
M
IPS
M
L
S
A
LSV
V
RE
K
E
L
G
S
I
IN
L
Y
V
T
P
T
T
RS
E
F
L
L
GK
-
---
Q
LP
Y
I
A
L
GM
L
NFF
L
L
CGLSVF
V
F
GVP
HK
GS
FL
TL
T
L
AAL
LY
IIIA
TG
M
GLLIST
FMK
SQ
I
A
A
IF
G
T
A
I
I
T
L
I
PA
TQ
F
SG
MID
PV
A
S
LEGPG
R
W
I
G
E
---VY
PT
S
HF
LT
IA
R
G
T
FS
K
A
L
D
L
T
DL
W
QL
F
I
PLL
I
fig|478007.5.peg.176
Escherichia coli O157:H7 str. EC508 (540-893/911)
LR
RLFS
Y
SR
R
E
A
L
E
L
R
RDP
VRSTLALMGT
V
I
L
M
L
I
M
G
Y
GI
S
M
---------
D
V
E
N
L
R
F
A
V
L
D
R
DQ
TVS
S
QAW
T
LN
L
S
G
SRY
F
IEQ
P
L
L
T
S
Y
DE
L
D
RR
M
R
AG
DI
T
V
AI
E
IPPNF
G
R
--
D
IAR
G
T
P
V
E
L
G
V
W
I
DG
AMP
S
R
A
E
T
VK
GY
V
Q
A
M
HQSWL
Q
DVAS
R
QST
P
S
SQS
G
L
M
NI
ETR
Y
RYNP
DVK
SL
PA
I
VP
A
VI
P
L
L
--
L
M
M
IPS
M
L
S
A
LSV
V
RE
K
E
L
G
S
I
IN
L
Y
V
T
P
T
T
RS
E
F
L
L
GK
-
---
Q
LP
Y
I
A
L
GM
L
NFF
L
L
CGLSVF
V
F
GVP
HK
GS
FL
TL
T
L
AAL
LY
IIIA
TG
M
GLLIST
FMK
SQ
I
A
A
IF
G
T
A
I
I
T
L
I
PA
TQ
F
SG
MID
PV
A
S
LEGPG
R
W
I
G
E
---VY
PT
S
HF
LT
IA
R
G
T
FS
K
A
L
D
L
T
DL
W
QL
F
I
PLL
I
fig|478008.5.peg.698
Escherichia coli O157:H7 str. EC869 (540-893/911)
LR
RLFS
Y
SR
R
E
A
L
E
L
R
RDP
VRSTLALMGT
V
I
L
M
L
I
M
G
Y
GI
S
M
---------
D
V
E
N
L
R
F
A
V
L
D
R
DQ
TVS
S
QAW
T
LN
L
S
G
SRY
F
IEQ
P
L
L
T
S
Y
DE
L
D
RR
M
R
AG
DI
T
V
AI
E
IPPNF
G
R
--
D
IAR
G
T
P
V
E
L
G
V
W
I
DG
AMP
S
R
A
E
T
VK
GY
V
Q
A
M
HQSWL
Q
DVAS
R
QST
P
S
SQS
G
L
M
NI
ETR
Y
RYNP
DVK
SL
PA
I
VP
A
VI
P
L
L
--
L
M
M
IPS
M
L
S
A
LSV
V
RE
K
E
L
G
S
I
IN
L
Y
V
T
P
T
T
RS
E
F
L
L
GK
-
---
Q
LP
Y
I
A
L
GM
L
NFF
L
L
CGLSVF
V
F
GVP
HK
GS
FL
TL
T
L
AAL
LY
IIIA
TG
M
GLLIST
FMK
SQ
I
A
A
IF
G
T
A
I
I
T
L
I
PA
TQ
F
SG
MID
PV
A
S
LEGPG
R
W
I
G
E
---VY
PT
S
HF
LT
IA
R
G
T
FS
K
A
L
D
L
T
DL
W
QL
F
I
PLL
I
fig|637388.3.peg.1889
Escherichia coli O157:H7 str. FRIK2000 (540-893/911)
LR
RLFS
Y
SR
R
E
A
L
E
L
R
RDP
VRSTLALMGT
V
I
L
M
L
I
M
G
Y
GI
S
M
---------
D
V
E
N
L
R
F
A
V
L
D
R
DQ
TVS
S
QAW
T
LN
L
S
G
SRY
F
IEQ
P
L
L
T
S
Y
DE
L
D
RR
M
R
AG
DI
T
V
AI
E
IPPNF
G
R
--
D
IAR
G
T
P
V
E
L
G
V
W
I
DG
AMP
S
R
A
E
T
VK
GY
V
Q
A
M
HQSWL
Q
DVAS
R
QST
P
S
SQS
G
L
M
NI
ETR
Y
RYNP
DVK
SL
PA
I
VP
A
VI
P
L
L
--
L
M
M
IPS
M
L
S
A
LSV
V
RE
K
E
L
G
S
I
IN
L
Y
V
T
P
T
T
RS
E
F
L
L
GK
-
---
Q
LP
Y
I
A
L
GM
L
NFF
L
L
CGLSVF
V
F
GVP
HK
GS
FL
TL
T
L
AAL
LY
IIIA
TG
M
GLLIST
FMK
SQ
I
A
A
IF
G
T
A
I
I
T
L
I
PA
TQ
F
SG
MID
PV
A
S
LEGPG
R
W
I
G
E
---VY
PT
S
HF
LT
IA
R
G
T
FS
K
A
L
D
L
T
DL
W
QL
F
I
PLL
I
fig|570506.3.peg.131
Escherichia coli O157:H7 str. FRIK966 (540-893/911)
LR
RLFS
Y
SR
R
E
A
L
E
L
R
RDP
VRSTLALMGT
V
I
L
M
L
I
M
G
Y
GI
S
M
---------
D
V
E
N
L
R
F
A
V
L
D
R
DQ
TVS
S
QAW
T
LN
L
S
G
SRY
F
IEQ
P
L
L
T
S
Y
DE
L
D
RR
M
R
AG
DI
T
V
AI
E
IPPNF
G
R
--
D
IAR
G
T
P
V
E
L
G
V
W
I
DG
AMP
S
R
A
E
T
VK
GY
V
Q
A
M
HQSWL
Q
DVAS
R
QST
P
S
SQS
G
L
M
NI
ETR
Y
RYNP
DVK
SL
PA
I
VP
A
VI
P
L
L
--
L
M
M
IPS
M
L
S
A
LSV
V
RE
K
E
L
G
S
I
IN
L
Y
V
T
P
T
T
RS
E
F
L
L
GK
-
---
Q
LP
Y
I
A
L
GM
L
NFF
L
L
CGLSVF
V
F
GVP
HK
GS
FL
TL
T
L
AAL
LY
IIIA
TG
M
GLLIST
FMK
SQ
I
A
A
IF
G
T
A
I
I
T
L
I
PA
TQ
F
SG
MID
PV
A
S
LEGPG
R
W
I
G
E
---VY
PT
S
HF
LT
IA
R
G
T
FS
K
A
L
D
L
T
DL
W
QL
F
I
PLL
I
fig|386585.9.peg.4551
Escherichia coli O157:H7 str. Sakai (540-893/911)
LR
RLFS
Y
SR
R
E
A
L
E
L
R
RDP
VRSTLALMGT
V
I
L
M
L
I
M
G
Y
GI
S
M
---------
D
V
E
N
L
R
F
A
V
L
D
R
DQ
TVS
S
QAW
T
LN
L
S
G
SRY
F
IEQ
P
L
L
T
S
Y
DE
L
D
RR
M
R
AG
DI
T
V
AI
E
IPPNF
G
R
--
D
IAR
G
T
P
V
E
L
G
V
W
I
DG
AMP
S
R
A
E
T
VK
GY
V
Q
A
M
HQSWL
Q
DVAS
R
QST
P
S
SQS
G
L
M
NI
ETR
Y
RYNP
DVK
SL
PA
I
VP
A
VI
P
L
L
--
L
M
M
IPS
M
L
S
A
LSV
V
RE
K
E
L
G
S
I
IN
L
Y
V
T
P
T
T
RS
E
F
L
L
GK
-
---
Q
LP
Y
I
A
L
GM
L
NFF
L
L
CGLSVF
V
F
GVP
HK
GS
FL
TL
T
L
AAL
LY
IIIA
TG
M
GLLIST
FMK
SQ
I
A
A
IF
G
T
A
I
I
T
L
I
PA
TQ
F
SG
MID
PV
A
S
LEGPG
R
W
I
G
E
---VY
PT
S
HF
LT
IA
R
G
T
FS
K
A
L
D
L
T
DL
W
QL
F
I
PLL
I
fig|544404.4.peg.4537
Escherichia coli O157:H7 str. TW14359 (540-893/911)
LR
RLFS
Y
SR
R
E
A
L
E
L
R
RDP
VRSTLALMGT
V
I
L
M
L
I
M
G
Y
GI
S
M
---------
D
V
E
N
L
R
F
A
V
L
D
R
DQ
TVS
S
QAW
T
LN
L
S
G
SRY
F
IEQ
P
L
L
T
S
Y
DE
L
D
RR
M
R
AG
DI
T
V
AI
E
IPPNF
G
R
--
D
IAR
G
T
P
V
E
L
G
V
W
I
DG
AMP
S
R
A
E
T
VK
GY
V
Q
A
M
HQSWL
Q
DVAS
R
QST
P
S
SQS
G
L
M
NI
ETR
Y
RYNP
DVK
SL
PA
I
VP
A
VI
P
L
L
--
L
M
M
IPS
M
L
S
A
LSV
V
RE
K
E
L
G
S
I
IN
L
Y
V
T
P
T
T
RS
E
F
L
L
GK
-
---
Q
LP
Y
I
A
L
GM
L
NFF
L
L
CGLSVF
V
F
GVP
HK
GS
FL
TL
T
L
AAL
LY
IIIA
TG
M
GLLIST
FMK
SQ
I
A
A
IF
G
T
A
I
I
T
L
I
PA
TQ
F
SG
MID
PV
A
S
LEGPG
R
W
I
G
E
---VY
PT
S
HF
LT
IA
R
G
T
FS
K
A
L
D
L
T
DL
W
QL
F
I
PLL
I
fig|502346.5.peg.2292
Escherichia coli O157:H7 str. TW14588 (540-893/911)
LR
RLFS
Y
SR
R
E
A
L
E
L
R
RDP
VRSTLALMGT
V
I
L
M
L
I
M
G
Y
GI
S
M
---------
D
V
E
N
L
R
F
A
V
L
D
R
DQ
TVS
S
QAW
T
LN
L
S
G
SRY
F
IEQ
P
L
L
T
S
Y
DE
L
D
RR
M
R
AG
DI
T
V
AI
E
IPPNF
G
R
--
D
IAR
G
T
P
V
E
L
G
V
W
I
DG
AMP
S
R
A
E
T
VK
GY
V
Q
A
M
HQSWL
Q
DVAS
R
QST
P
S
SQS
G
L
M
NI
ETR
Y
RYNP
DVK
SL
PA
I
VP
A
VI
P
L
L
--
L
M
M
IPS
M
L
S
A
LSV
V
RE
K
E
L
G
S
I
IN
L
Y
V
T
P
T
T
RS
E
F
L
L
GK
-
---
Q
LP
Y
I
A
L
GM
L
NFF
L
L
CGLSVF
V
F
GVP
HK
GS
FL
TL
T
L
AAL
LY
IIIA
TG
M
GLLIST
FMK
SQ
I
A
A
IF
G
T
A
I
I
T
L
I
PA
TQ
F
SG
MID
PV
A
S
LEGPG
R
W
I
G
E
---VY
PT
S
HF
LT
IA
R
G
T
FS
K
A
L
D
L
T
DL
W
QL
F
I
PLL
I
fig|83334.1.peg.4329
Escherichia coli O157:H7 (523-876/894)
LR
RLFS
Y
SR
R
E
A
L
E
L
R
RDP
VRSTLALMGT
V
I
L
M
L
I
M
G
Y
GI
S
M
---------
D
V
E
N
L
R
F
A
V
L
D
R
DQ
TVS
S
QAW
T
LN
L
S
G
SRY
F
IEQ
P
L
L
T
S
Y
DE
L
D
RR
M
R
AG
DI
T
V
AI
E
IPPNF
G
R
--
D
IAR
G
T
P
V
E
L
G
V
W
I
DG
AMP
S
R
A
E
T
VK
GY
V
Q
A
M
HQSWL
Q
DVAS
R
QST
P
S
SQS
G
L
M
NI
ETR
Y
RYNP
DVK
SL
PA
I
VP
A
VI
P
L
L
--
L
M
M
IPS
M
L
S
A
LSV
V
RE
K
E
L
G
S
I
IN
L
Y
V
T
P
T
T
RS
E
F
L
L
GK
-
---
Q
LP
Y
I
A
L
GM
L
NFF
L
L
CGLSVF
V
F
GVP
HK
GS
FL
TL
T
L
AAL
LY
IIIA
TG
M
GLLIST
FMK
SQ
I
A
A
IF
G
T
A
I
I
T
L
I
PA
TQ
F
SG
MID
PV
A
S
LEGPG
R
W
I
G
E
---VY
PT
S
HF
LT
IA
R
G
T
FS
K
A
L
D
L
T
DL
W
QL
F
I
PLL
I
fig|155864.1.peg.4366
Escherichia coli O157:H7 EDL933 (523-876/894)
LR
RLFS
Y
SR
R
E
A
L
E
L
R
RDP
VRSTLALMGT
V
I
L
M
L
I
M
G
Y
GI
S
M
---------
D
V
E
N
L
R
F
A
V
L
D
R
DQ
TVS
S
QAW
T
LN
L
S
G
SRY
F
IEQ
P
L
L
T
S
Y
DE
L
D
RR
M
R
AG
DI
T
V
AI
E
IPPNF
G
R
--
D
IAR
G
T
P
V
E
L
G
V
W
I
DG
AMP
S
R
A
E
T
VK
GY
V
Q
A
M
HQSWL
Q
DVAS
R
QST
P
S
SQS
G
L
M
NI
ETR
Y
RYNP
DVK
SL
PA
I
VP
A
VI
P
L
L
--
L
M
M
IPS
M
L
S
A
LSV
V
RE
K
E
L
G
S
I
IN
L
Y
V
T
P
T
T
RS
E
F
L
L
GK
-
---
Q
LP
Y
I
A
L
GM
L
NFF
L
L
CGLSVF
V
F
GVP
HK
GS
FL
TL
T
L
AAL
LY
IIIA
TG
M
GLLIST
FMK
SQ
I
A
A
IF
G
T
A
I
I
T
L
I
PA
TQ
F
SG
MID
PV
A
S
LEGPG
R
W
I
G
E
---VY
PT
S
HF
LT
IA
R
G
T
FS
K
A
L
D
L
T
DL
W
QL
F
I
PLL
I
fig|656440.3.peg.3739
Escherichia coli TA206 (540-893/911)
LR
RLFS
Y
SR
R
E
A
L
E
L
R
RDP
VRSTLALMGT
V
I
L
M
L
I
M
G
Y
GI
S
M
---------
D
V
E
N
L
R
F
A
V
L
D
R
DQ
TVS
S
QAW
T
LN
L
S
G
SRY
F
IEQ
P
P
L
T
S
Y
DE
L
D
RR
M
R
AG
DI
T
V
AI
E
IPPNF
G
R
--
D
IAR
G
T
P
V
E
L
G
V
W
I
DG
AMP
S
R
A
E
M
VK
GY
V
Q
A
M
HQSWL
Q
DVAS
R
QST
P
A
SQS
G
L
M
NI
ETR
Y
RYNP
DVK
SL
PA
I
VP
A
VI
P
L
L
--
L
M
M
IPS
M
L
S
A
LSV
V
RE
K
E
L
G
S
I
IN
L
Y
V
T
P
T
T
RS
E
F
L
L
GK
-
---
Q
LP
Y
I
A
L
GM
L
NFF
L
L
CALSVF
V
F
GVP
HK
GS
FL
TL
T
L
AAL
LY
IIIA
TG
M
GLLIST
FMK
SQ
I
A
A
IF
G
T
A
I
I
T
L
I
PA
TQ
F
SG
MID
PV
A
S
LEGPG
R
W
I
G
E
---VY
PT
S
HF
LT
IA
R
G
T
FS
K
A
L
D
L
T
DL
W
QL
F
I
PLL
I
fig|362663.8.peg.3611
Escherichia coli 536 (540-893/911)
LR
RLFS
Y
SR
R
E
A
L
E
L
R
RDP
VRSTLALMGT
V
I
L
M
L
I
M
G
Y
GI
S
M
---------
D
V
E
N
L
R
F
A
V
L
D
R
DQ
TVS
S
QAW
T
LN
L
S
G
SRY
F
IEQ
P
P
L
T
S
Y
DE
L
D
RR
M
R
AG
DI
T
V
AI
E
IPPNF
G
R
--
D
IAR
G
T
P
V
E
L
G
V
W
I
DG
AMP
S
R
A
E
T
VK
GY
V
Q
A
M
HQSWL
Q
DVAS
R
QST
P
S
SQS
V
L
M
NI
ETR
Y
RYNP
DVK
SL
PA
I
VP
A
VI
P
L
L
--
L
M
M
IPS
M
L
S
A
LSV
V
RE
K
E
L
G
S
I
IN
L
Y
V
T
P
T
T
RS
E
F
L
L
GK
-
---
Q
LP
Y
I
A
L
GM
L
NFF
L
L
CGLSVF
V
F
GVP
HK
GS
FL
TL
T
L
AAL
LY
IIIA
TG
M
GLLIST
FMK
SQ
I
A
A
IF
G
T
A
I
I
T
L
I
PA
TQ
F
SG
MID
PV
A
S
LEGPG
R
W
I
G
E
---VY
PT
S
HF
LT
IA
R
G
T
FS
K
A
L
D
L
T
DL
W
QL
F
I
PLL
I
fig|362663.9.peg.3623
Escherichia coli 536 (540-893/911)
LR
RLFS
Y
SR
R
E
A
L
E
L
R
RDP
VRSTLALMGT
V
I
L
M
L
I
M
G
Y
GI
S
M
---------
D
V
E
N
L
R
F
A
V
L
D
R
DQ
TVS
S
QAW
T
LN
L
S
G
SRY
F
IEQ
P
P
L
T
S
Y
DE
L
D
RR
M
R
AG
DI
T
V
AI
E
IPPNF
G
R
--
D
IAR
G
T
P
V
E
L
G
V
W
I
DG
AMP
S
R
A
E
T
VK
GY
V
Q
A
M
HQSWL
Q
DVAS
R
QST
P
S
SQS
V
L
M
NI
ETR
Y
RYNP
DVK
SL
PA
I
VP
A
VI
P
L
L
--
L
M
M
IPS
M
L
S
A
LSV
V
RE
K
E
L
G
S
I
IN
L
Y
V
T
P
T
T
RS
E
F
L
L
GK
-
---
Q
LP
Y
I
A
L
GM
L
NFF
L
L
CGLSVF
V
F
GVP
HK
GS
FL
TL
T
L
AAL
LY
IIIA
TG
M
GLLIST
FMK
SQ
I
A
A
IF
G
T
A
I
I
T
L
I
PA
TQ
F
SG
MID
PV
A
S
LEGPG
R
W
I
G
E
---VY
PT
S
HF
LT
IA
R
G
T
FS
K
A
L
D
L
T
DL
W
QL
F
I
PLL
I
fig|340197.3.peg.684
Escherichia coli F11 (540-893/911)
LR
RLFS
Y
SR
R
E
A
L
E
L
R
RDP
VRSTLALMGT
V
I
L
M
L
I
M
G
Y
GI
S
M
---------
D
V
E
N
L
R
F
A
V
L
D
R
DQ
TVS
S
QAW
T
LN
L
S
G
SRY
F
IEQ
P
P
L
T
S
Y
DE
L
D
RR
M
R
AG
DI
T
V
AI
E
IPPNF
G
R
--
D
IAR
G
T
P
V
E
L
G
V
W
I
DG
AMP
S
R
A
E
T
VK
GY
V
Q
A
M
HQSWL
Q
DVAS
R
QST
P
S
SQS
V
L
M
NI
ETR
Y
RYNP
DVK
SL
PA
I
VP
A
VI
P
L
L
--
L
M
M
IPS
M
L
S
A
LSV
V
RE
K
E
L
G
S
I
IN
L
Y
V
T
P
T
T
RS
E
F
L
L
GK
-
---
Q
LP
Y
I
A
L
GM
L
NFF
L
L
CGLSVF
V
F
GVP
HK
GS
FL
TL
T
L
AAL
LY
IIIA
TG
M
GLLIST
FMK
SQ
I
A
A
IF
G
T
A
I
I
T
L
I
PA
TQ
F
SG
MID
PV
A
S
LEGPG
R
W
I
G
E
---VY
PT
S
HF
LT
IA
R
G
T
FS
K
A
L
D
L
T
DL
W
QL
F
I
PLL
I
fig|340197.5.peg.710
Escherichia coli F11 (540-893/911)
LR
RLFS
Y
SR
R
E
A
L
E
L
R
RDP
VRSTLALMGT
V
I
L
M
L
I
M
G
Y
GI
S
M
---------
D
V
E
N
L
R
F
A
V
L
D
R
DQ
TVS
S
QAW
T
LN
L
S
G
SRY
F
IEQ
P
P
L
T
S
Y
DE
L
D
RR
M
R
AG
DI
T
V
AI
E
IPPNF
G
R
--
D
IAR
G
T
P
V
E
L
G
V
W
I
DG
AMP
S
R
A
E
T
VK
GY
V
Q
A
M
HQSWL
Q
DVAS
R
QST
P
S
SQS
V
L
M
NI
ETR
Y
RYNP
DVK
SL
PA
I
VP
A
VI
P
L
L
--
L
M
M
IPS
M
L
S
A
LSV
V
RE
K
E
L
G
S
I
IN
L
Y
V
T
P
T
T
RS
E
F
L
L
GK
-
---
Q
LP
Y
I
A
L
GM
L
NFF
L
L
CGLSVF
V
F
GVP
HK
GS
FL
TL
T
L
AAL
LY
IIIA
TG
M
GLLIST
FMK
SQ
I
A
A
IF
G
T
A
I
I
T
L
I
PA
TQ
F
SG
MID
PV
A
S
LEGPG
R
W
I
G
E
---VY
PT
S
HF
LT
IA
R
G
T
FS
K
A
L
D
L
T
DL
W
QL
F
I
PLL
I
fig|749550.3.peg.3097
Escherichia coli MS 200-1 (540-893/911)
LR
RLFS
Y
SR
R
E
A
L
E
L
R
RDP
VRSTLALMGT
V
I
L
M
L
I
M
G
Y
GI
S
M
---------
D
V
E
N
L
R
F
A
V
L
D
R
DQ
TVS
S
QAW
T
LN
L
S
G
SRY
F
IEQ
P
P
L
T
S
Y
DE
L
D
RR
M
R
AG
DI
T
V
AI
E
IPPNF
G
R
--
D
IAR
G
T
P
V
E
L
G
V
W
I
DG
AMP
S
R
A
E
T
VK
GY
V
Q
A
M
HQSWL
Q
DVAS
R
QST
P
S
SQS
V
L
M
NI
ETR
Y
RYNP
DVK
SL
PA
I
VP
A
VI
P
L
L
--
L
M
M
IPS
M
L
S
A
LSV
V
RE
K
E
L
G
S
I
IN
L
Y
V
T
P
T
T
RS
E
F
L
L
GK
-
---
Q
LP
Y
I
A
L
GM
L
NFF
L
L
CGLSVF
V
F
GVP
HK
GS
FL
TL
T
L
AAL
LY
IIIA
TG
M
GLLIST
FMK
SQ
I
A
A
IF
G
T
A
I
I
T
L
I
PA
TQ
F
SG
MID
PV
A
S
LEGPG
R
W
I
G
E
---VY
PT
S
HF
LT
IA
R
G
T
FS
K
A
L
D
L
T
DL
W
QL
F
I
PLL
I
fig|701177.3.peg.4230
Escherichia coli O55:H7 str. CB9615 (540-893/911)
LR
RLFS
Y
SR
R
E
A
L
E
L
R
RDP
VRSTLALMGT
V
I
L
M
L
I
M
G
Y
GI
S
M
---------
D
V
E
N
L
R
F
A
V
L
D
C
DQ
TVS
S
QAW
T
LN
L
S
G
SRY
F
IEQ
P
L
L
T
S
Y
DE
L
D
RR
M
R
AG
DI
T
V
AI
E
IPPNF
G
R
--
D
IAR
G
T
P
V
E
L
G
V
W
I
DG
AMP
S
R
A
E
T
VK
GY
V
Q
A
M
HQSWL
Q
DVAS
R
QST
P
S
SQS
G
L
M
NI
ETR
Y
RYNP
DVK
SL
PA
I
VP
A
VI
P
L
L
--
L
M
M
IPS
M
L
S
A
LSV
V
RE
K
E
L
G
S
I
IN
L
Y
V
T
P
T
T
RS
E
F
L
L
GK
-
---
Q
LP
Y
I
A
L
GM
L
NFF
L
L
CGLSVF
V
F
GVP
HK
GS
FL
TL
T
L
AAL
LY
IIIA
TG
M
GLLIST
FMK
SQ
I
A
A
IF
G
T
A
I
I
T
L
I
PA
TQ
F
SG
MID
PV
A
S
LEGPG
R
W
I
G
E
---VY
PT
S
HF
LT
IA
R
G
T
FS
K
A
L
D
L
T
DL
W
QL
F
I
PLL
I
fig|749546.3.peg.3976
Escherichia coli MS 185-1 (540-893/911)
LR
RLFS
Y
SR
R
E
A
L
E
L
R
RDP
VRSTLALMGT
V
I
L
M
L
I
M
G
Y
GI
S
M
---------
D
V
E
N
L
R
F
A
V
L
D
R
DQ
TVS
S
QAW
T
LN
L
S
G
SRY
F
IEQ
P
P
L
T
S
Y
DE
L
D
RR
M
R
AG
DI
T
V
AI
E
IPPNF
G
R
--
D
IAR
G
T
P
V
E
L
G
V
W
I
DG
AMP
S
R
A
E
T
VK
GY
V
Q
A
M
HQSWL
Q
DVAS
R
QST
P
A
SQS
G
L
M
NI
ETR
Y
RYNP
DVK
SL
PA
I
VP
A
VI
P
L
L
--
L
M
M
IPS
M
L
S
A
LSV
V
RE
K
E
L
G
S
I
IN
L
Y
V
T
P
T
T
RS
E
F
L
L
GK
-
---
Q
LP
Y
I
A
L
GM
L
NFF
L
L
CALSVF
V
F
GVP
HK
GS
FL
TL
T
L
AAL
LY
IIIA
TG
M
GLLIST
FMK
SQ
I
A
A
IF
G
T
A
V
I
T
L
I
PA
TQ
F
SG
MID
PV
A
S
LEGPG
R
W
I
G
E
---VY
PT
S
HF
LT
IA
R
G
T
FS
K
A
L
D
L
T
DL
W
QL
F
I
PLL
I
fig|562.376.peg.2769
Escherichia coli WV_060327 (540-893/911)
LR
RLFS
Y
SR
R
E
A
L
E
L
R
RDP
VRSTLALMGT
V
I
L
M
L
I
M
G
Y
GI
S
M
---------
D
V
E
N
L
R
F
A
V
L
D
R
DQ
TVS
S
QAW
T
LN
L
S
G
SRY
F
IEQ
P
P
L
T
S
Y
DE
L
D
RR
M
R
AG
DI
T
V
AI
E
IPPNF
G
R
--
D
IAR
G
T
P
V
E
L
G
V
W
I
DG
AMP
S
R
A
E
T
VK
GY
V
Q
A
M
HQSWL
Q
DVAS
R
QST
P
A
SQS
G
L
M
NI
ETR
Y
RYNP
DVK
SL
PA
I
VP
A
VI
P
L
L
--
L
M
M
IPS
M
L
S
A
LSV
V
RE
K
E
L
G
S
I
IN
L
Y
V
T
P
T
T
RS
E
F
L
L
GK
-
---
Q
LP
Y
I
A
L
GM
L
NFF
L
L
CALSVF
V
F
GVP
HK
GS
FL
TL
T
L
AAL
LY
IIIA
TG
M
GLLIST
FMK
SQ
I
A
A
IF
G
T
A
I
I
T
L
I
PA
TQ
F
SG
MID
PV
A
S
LEGPG
R
W
I
G
E
---VY
PT
S
HF
LT
IA
R
G
T
FS
K
A
L
D
L
T
DL
W
QL
F
I
PLL
I
fig|670897.3.peg.3872
Escherichia coli 2362-75 (540-893/911)
LR
RLFS
Y
SR
R
E
A
L
E
L
R
RDP
VRSTLALMGT
V
I
L
M
L
I
M
G
Y
GI
S
M
---------
D
V
E
N
L
R
F
A
V
L
D
R
DQ
TVS
S
QAW
T
LN
L
S
G
SRY
F
IEQ
P
P
L
T
S
Y
DE
L
D
RR
M
R
V
G
DI
T
V
AI
E
IPPNF
G
R
--
D
IAR
G
T
P
V
E
L
G
V
W
I
DG
AMP
S
R
A
E
T
VK
GY
V
Q
A
M
HQSWL
Q
DVAS
R
QST
P
A
SQS
G
L
M
NI
ETR
Y
RYNP
DVK
SL
PA
I
VP
A
VI
P
L
L
--
L
M
M
IPS
M
L
S
A
LSV
V
RE
K
E
L
G
S
I
IN
L
Y
V
T
P
T
T
RS
E
F
L
L
GK
-
---
Q
LP
Y
I
A
L
GM
L
NFF
L
L
CALSVF
V
F
GVP
HK
GS
FL
TL
T
L
AAL
LY
IIIA
TG
M
GLLIST
FMK
SQ
I
A
A
IF
G
T
A
I
I
T
L
I
PA
TQ
F
SG
MID
PV
A
S
LEGPG
R
W
I
G
E
---VY
PT
S
HF
LT
IA
R
G
T
FS
K
A
L
D
L
T
DL
W
QL
F
I
PLL
I
fig|525281.3.peg.2931
Escherichia coli 83972 (540-893/911)
LR
RLFS
Y
SR
R
E
A
L
E
L
R
RDP
VRSTLALMGT
V
I
L
M
L
I
M
G
Y
GI
S
M
---------
D
V
E
N
L
R
F
A
V
L
D
R
DQ
TVS
S
QAW
T
LN
L
S
G
SRY
F
IEQ
P
P
L
T
S
Y
DE
L
D
RR
M
R
AG
DI
T
V
AI
E
IPPNF
G
R
--
D
IAR
G
T
P
V
E
L
G
V
W
I
DG
AMP
S
R
A
E
T
VK
GY
V
Q
A
M
HQSWL
Q
DVAS
R
QST
P
A
SQS
G
L
M
NI
ETR
Y
RYNP
DVK
SL
PA
I
VP
A
VI
P
L
L
--
L
M
M
IPS
M
L
S
A
LSV
V
RE
K
E
L
G
S
I
IN
L
Y
V
T
P
T
T
RS
E
F
L
L
GK
-
---
Q
LP
Y
I
A
L
GM
L
NFF
L
L
CALSVF
V
F
GVP
HK
GS
FL
TL
T
L
AAL
LY
IIIA
TG
M
GLLIST
FMK
SQ
I
A
A
IF
G
T
A
I
I
T
L
I
PA
TQ
F
SG
MID
PV
A
S
LEGPG
R
W
I
G
E
---VY
PT
S
HF
LT
IA
R
G
T
FS
K
A
L
D
L
T
DL
W
QL
F
I
PLL
I
fig|655817.3.peg.4088
Escherichia coli ABU 83972 (540-893/911)
LR
RLFS
Y
SR
R
E
A
L
E
L
R
RDP
VRSTLALMGT
V
I
L
M
L
I
M
G
Y
GI
S
M
---------
D
V
E
N
L
R
F
A
V
L
D
R
DQ
TVS
S
QAW
T
LN
L
S
G
SRY
F
IEQ
P
P
L
T
S
Y
DE
L
D
RR
M
R
AG
DI
T
V
AI
E
IPPNF
G
R
--
D
IAR
G
T
P
V
E
L
G
V
W
I
DG
AMP
S
R
A
E
T
VK
GY
V
Q
A
M
HQSWL
Q
DVAS
R
QST
P
A
SQS
G
L
M
NI
ETR
Y
RYNP
DVK
SL
PA
I
VP
A
VI
P
L
L
--
L
M
M
IPS
M
L
S
A
LSV
V
RE
K
E
L
G
S
I
IN
L
Y
V
T
P
T
T
RS
E
F
L
L
GK
-
---
Q
LP
Y
I
A
L
GM
L
NFF
L
L
CALSVF
V
F
GVP
HK
GS
FL
TL
T
L
AAL
LY
IIIA
TG
M
GLLIST
FMK
SQ
I
A
A
IF
G
T
A
I
I
T
L
I
PA
TQ
F
SG
MID
PV
A
S
LEGPG
R
W
I
G
E
---VY
PT
S
HF
LT
IA
R
G
T
FS
K
A
L
D
L
T
DL
W
QL
F
I
PLL
I
fig|405955.13.peg.3922
Escherichia coli APEC O1 (540-893/911)
LR
RLFS
Y
SR
R
E
A
L
E
L
R
RDP
VRSTLALMGT
V
I
L
M
L
I
M
G
Y
GI
S
M
---------
D
V
E
N
L
R
F
A
V
L
D
R
DQ
TVS
S
QAW
T
LN
L
S
G
SRY
F
IEQ
P
P
L
T
S
Y
DE
L
D
RR
M
R
AG
DI
T
V
AI
E
IPPNF
G
R
--
D
IAR
G
T
P
V
E
L
G
V
W
I
DG
AMP
S
R
A
E
T
VK
GY
V
Q
A
M
HQSWL
Q
DVAS
R
QST
P
A
SQS
G
L
M
NI
ETR
Y
RYNP
DVK
SL
PA
I
VP
A
VI
P
L
L
--
L
M
M
IPS
M
L
S
A
LSV
V
RE
K
E
L
G
S
I
IN
L
Y
V
T
P
T
T
RS
E
F
L
L
GK
-
---
Q
LP
Y
I
A
L
GM
L
NFF
L
L
CALSVF
V
F
GVP
HK
GS
FL
TL
T
L
AAL
LY
IIIA
TG
M
GLLIST
FMK
SQ
I
A
A
IF
G
T
A
I
I
T
L
I
PA
TQ
F
SG
MID
PV
A
S
LEGPG
R
W
I
G
E
---VY
PT
S
HF
LT
IA
R
G
T
FS
K
A
L
D
L
T
DL
W
QL
F
I
PLL
I
fig|405955.9.peg.3283
Escherichia coli APEC O1 (540-893/911)
LR
RLFS
Y
SR
R
E
A
L
E
L
R
RDP
VRSTLALMGT
V
I
L
M
L
I
M
G
Y
GI
S
M
---------
D
V
E
N
L
R
F
A
V
L
D
R
DQ
TVS
S
QAW
T
LN
L
S
G
SRY
F
IEQ
P
P
L
T
S
Y
DE
L
D
RR
M
R
AG
DI
T
V
AI
E
IPPNF
G
R
--
D
IAR
G
T
P
V
E
L
G
V
W
I
DG
AMP
S
R
A
E
T
VK
GY
V
Q
A
M
HQSWL
Q
DVAS
R
QST
P
A
SQS
G
L
M
NI
ETR
Y
RYNP
DVK
SL
PA
I
VP
A
VI
P
L
L
--
L
M
M
IPS
M
L
S
A
LSV
V
RE
K
E
L
G
S
I
IN
L
Y
V
T
P
T
T
RS
E
F
L
L
GK
-
---
Q
LP
Y
I
A
L
GM
L
NFF
L
L
CALSVF
V
F
GVP
HK
GS
FL
TL
T
L
AAL
LY
IIIA
TG
M
GLLIST
FMK
SQ
I
A
A
IF
G
T
A
I
I
T
L
I
PA
TQ
F
SG
MID
PV
A
S
LEGPG
R
W
I
G
E
---VY
PT
S
HF
LT
IA
R
G
T
FS
K
A
L
D
L
T
DL
W
QL
F
I
PLL
I
fig|199310.1.peg.4191
Escherichia coli CFT073 (540-893/911)
LR
RLFS
Y
SR
R
E
A
L
E
L
R
RDP
VRSTLALMGT
V
I
L
M
L
I
M
G
Y
GI
S
M
---------
D
V
E
N
L
R
F
A
V
L
D
R
DQ
TVS
S
QAW
T
LN
L
S
G
SRY
F
IEQ
P
P
L
T
S
Y
DE
L
D
RR
M
R
AG
DI
T
V
AI
E
IPPNF
G
R
--
D
IAR
G
T
P
V
E
L
G
V
W
I
DG
AMP
S
R
A
E
T
VK
GY
V
Q
A
M
HQSWL
Q
DVAS
R
QST
P
A
SQS
G
L
M
NI
ETR
Y
RYNP
DVK
SL
PA
I
VP
A
VI
P
L
L
--
L
M
M
IPS
M
L
S
A
LSV
V
RE
K
E
L
G
S
I
IN
L
Y
V
T
P
T
T
RS
E
F
L
L
GK
-
---
Q
LP
Y
I
A
L
GM
L
NFF
L
L
CALSVF
V
F
GVP
HK
GS
FL
TL
T
L
AAL
LY
IIIA
TG
M
GLLIST
FMK
SQ
I
A
A
IF
G
T
A
I
I
T
L
I
PA
TQ
F
SG
MID
PV
A
S
LEGPG
R
W
I
G
E
---VY
PT
S
HF
LT
IA
R
G
T
FS
K
A
L
D
L
T
DL
W
QL
F
I
PLL
I
fig|199310.4.peg.4027
Escherichia coli CFT073 (540-893/911)
LR
RLFS
Y
SR
R
E
A
L
E
L
R
RDP
VRSTLALMGT
V
I
L
M
L
I
M
G
Y
GI
S
M
---------
D
V
E
N
L
R
F
A
V
L
D
R
DQ
TVS
S
QAW
T
LN
L
S
G
SRY
F
IEQ
P
P
L
T
S
Y
DE
L
D
RR
M
R
AG
DI
T
V
AI
E
IPPNF
G
R
--
D
IAR
G
T
P
V
E
L
G
V
W
I
DG
AMP
S
R
A
E
T
VK
GY
V
Q
A
M
HQSWL
Q
DVAS
R
QST
P
A
SQS
G
L
M
NI
ETR
Y
RYNP
DVK
SL
PA
I
VP
A
VI
P
L
L
--
L
M
M
IPS
M
L
S
A
LSV
V
RE
K
E
L
G
S
I
IN
L
Y
V
T
P
T
T
RS
E
F
L
L
GK
-
---
Q
LP
Y
I
A
L
GM
L
NFF
L
L
CALSVF
V
F
GVP
HK
GS
FL
TL
T
L
AAL
LY
IIIA
TG
M
GLLIST
FMK
SQ
I
A
A
IF
G
T
A
I
I
T
L
I
PA
TQ
F
SG
MID
PV
A
S
LEGPG
R
W
I
G
E
---VY
PT
S
HF
LT
IA
R
G
T
FS
K
A
L
D
L
T
DL
W
QL
F
I
PLL
I
fig|216593.1.peg.4208
Escherichia coli E2348/69 (540-893/911)
LR
RLFS
Y
SR
R
E
A
L
E
L
R
RDP
VRSTLALMGT
V
I
L
M
L
I
M
G
Y
GI
S
M
---------
D
V
E
N
L
R
F
A
V
L
D
R
DQ
TVS
S
QAW
T
LN
L
S
G
SRY
F
IEQ
P
P
L
T
S
Y
DE
L
D
RR
M
R
V
G
DI
T
V
AI
E
IPPNF
G
R
--
D
IAR
G
T
P
V
E
L
G
V
W
I
DG
AMP
S
R
A
E
T
VK
GY
V
Q
A
M
HQSWL
Q
DVAS
R
QST
P
A
SQS
G
L
M
NI
ETR
Y
RYNP
DVK
SL
PA
I
VP
A
VI
P
L
L
--
L
M
M
IPS
M
L
S
A
LSV
V
RE
K
E
L
G
S
I
IN
L
Y
V
T
P
T
T
RS
E
F
L
L
GK
-
---
Q
LP
Y
I
A
L
GM
L
NFF
L
L
CALSVF
V
F
GVP
HK
GS
FL
TL
T
L
AAL
LY
IIIA
TG
M
GLLIST
FMK
SQ
I
A
A
IF
G
T
A
I
I
T
L
I
PA
TQ
F
SG
MID
PV
A
S
LEGPG
R
W
I
G
E
---VY
PT
S
HF
LT
IA
R
G
T
FS
K
A
L
D
L
T
DL
W
QL
F
I
PLL
I
fig|585397.7.peg.4147
Escherichia coli ED1a (540-893/911)
LR
RLFS
Y
SR
R
E
A
L
E
L
R
RDP
VRSTLALMGT
V
I
L
M
L
I
M
G
Y
GI
S
M
---------
D
V
E
N
L
R
F
A
V
L
D
R
DQ
TVS
S
QAW
T
LN
L
S
G
SRY
F
IEQ
P
P
L
T
S
Y
DE
L
D
RR
M
R
AG
DI
T
V
AI
E
IPPNF
G
R
--
D
IAR
G
T
P
V
E
L
G
V
W
I
DG
AMP
S
R
A
E
T
VK
GY
V
Q
A
M
HQSWL
Q
DVAS
R
QST
P
A
SQS
G
L
M
NI
ETR
Y
RYNP
DVK
SL
PA
I
VP
A
VI
P
L
L
--
L
M
M
IPS
M
L
S
A
LSV
V
RE
K
E
L
G
S
I
IN
L
Y
V
T
P
T
T
RS
E
F
L
L
GK
-
---
Q
LP
Y
I
A
L
GM
L
NFF
L
L
CALSVF
V
F
GVP
HK
GS
FL
TL
T
L
AAL
LY
IIIA
TG
M
GLLIST
FMK
SQ
I
A
A
IF
G
T
A
I
I
T
L
I
PA
TQ
F
SG
MID
PV
A
S
LEGPG
R
W
I
G
E
---VY
PT
S
HF
LT
IA
R
G
T
FS
K
A
L
D
L
T
DL
W
QL
F
I
PLL
I
fig|585397.9.peg.4143
Escherichia coli ED1a (540-893/911)
LR
RLFS
Y
SR
R
E
A
L
E
L
R
RDP
VRSTLALMGT
V
I
L
M
L
I
M
G
Y
GI
S
M
---------
D
V
E
N
L
R
F
A
V
L
D
R
DQ
TVS
S
QAW
T
LN
L
S
G
SRY
F
IEQ
P
P
L
T
S
Y
DE
L
D
RR
M
R
AG
DI
T
V
AI
E
IPPNF
G
R
--
D
IAR
G
T
P
V
E
L
G
V
W
I
DG
AMP
S
R
A
E
T
VK
GY
V
Q
A
M
HQSWL
Q
DVAS
R
QST
P
A
SQS
G
L
M
NI
ETR
Y
RYNP
DVK
SL
PA
I
VP
A
VI
P
L
L
--
L
M
M
IPS
M
L
S
A
LSV
V
RE
K
E
L
G
S
I
IN
L
Y
V
T
P
T
T
RS
E
F
L
L
GK
-
---
Q
LP
Y
I
A
L
GM
L
NFF
L
L
CALSVF
V
F
GVP
HK
GS
FL
TL
T
L
AAL
LY
IIIA
TG
M
GLLIST
FMK
SQ
I
A
A
IF
G
T
A
I
I
T
L
I
PA
TQ
F
SG
MID
PV
A
S
LEGPG
R
W
I
G
E
---VY
PT
S
HF
LT
IA
R
G
T
FS
K
A
L
D
L
T
DL
W
QL
F
I
PLL
I
fig|714962.3.peg.3954
Escherichia coli IHE3034 (540-893/911)
LR
RLFS
Y
SR
R
E
A
L
E
L
R
RDP
VRSTLALMGT
V
I
L
M
L
I
M
G
Y
GI
S
M
---------
D
V
E
N
L
R
F
A
V
L
D
R
DQ
TVS
S
QAW
T
LN
L
S
G
SRY
F
IEQ
P
P
L
T
S
Y
DE
L
D
RR
M
R
AG
DI
T
V
AI
E
IPPNF
G
R
--
D
IAR
G
T
P
V
E
L
G
V
W
I
DG
AMP
S
R
A
E
T
VK
GY
V
Q
A
M
HQSWL
Q
DVAS
R
QST
P
A
SQS
G
L
M
NI
ETR
Y
RYNP
DVK
SL
PA
I
VP
A
VI
P
L
L
--
L
M
M
IPS
M
L
S
A
LSV
V
RE
K
E
L
G
S
I
IN
L
Y
V
T
P
T
T
RS
E
F
L
L
GK
-
---
Q
LP
Y
I
A
L
GM
L
NFF
L
L
CALSVF
V
F
GVP
HK
GS
FL
TL
T
L
AAL
LY
IIIA
TG
M
GLLIST
FMK
SQ
I
A
A
IF
G
T
A
I
I
T
L
I
PA
TQ
F
SG
MID
PV
A
S
LEGPG
R
W
I
G
E
---VY
PT
S
HF
LT
IA
R
G
T
FS
K
A
L
D
L
T
DL
W
QL
F
I
PLL
I
fig|656417.3.peg.4345
Escherichia coli M605 (540-893/911)
LR
RLFS
Y
SR
R
E
A
L
E
L
R
RDP
VRSTLALMGT
V
I
L
M
L
I
M
G
Y
GI
S
M
---------
D
V
E
N
L
R
F
A
V
L
D
R
DQ
TVS
S
QAW
T
LN
L
S
G
SRY
F
IEQ
P
P
L
T
S
Y
DE
L
D
RR
M
R
AG
DI
T
V
AI
E
IPPNF
G
R
--
D
IAR
G
T
P
V
E
L
G
V
W
I
DG
AMP
S
R
A
E
T
VK
GY
V
Q
A
M
HQSWL
Q
DVAS
R
QST
P
A
SQS
G
L
M
NI
ETR
Y
RYNP
DVK
SL
PA
I
VP
A
VI
P
L
L
--
L
M
M
IPS
M
L
S
A
LSV
V
RE
K
E
L
G
S
I
IN
L
Y
V
T
P
T
T
RS
E
F
L
L
GK
-
---
Q
LP
Y
I
A
L
GM
L
NFF
L
L
CALSVF
V
F
GVP
HK
GS
FL
TL
T
L
AAL
LY
IIIA
TG
M
GLLIST
FMK
SQ
I
A
A
IF
G
T
A
I
I
T
L
I
PA
TQ
F
SG
MID
PV
A
S
LEGPG
R
W
I
G
E
---VY
PT
S
HF
LT
IA
R
G
T
FS
K
A
L
D
L
T
DL
W
QL
F
I
PLL
I
fig|753642.3.peg.4461
Escherichia coli NC101 (540-893/911)
LR
RLFS
Y
SR
R
E
A
L
E
L
R
RDP
VRSTLALMGT
V
I
L
M
L
I
M
G
Y
GI
S
M
---------
D
V
E
N
L
R
F
A
V
L
D
R
DQ
TVS
S
QAW
T
LN
L
S
G
SRY
F
IEQ
P
P
L
T
S
Y
DE
L
D
RR
M
R
AG
DI
T
V
AI
E
IPPNF
G
R
--
D
IAR
G
T
P
V
E
L
G
V
W
I
DG
AMP
S
R
A
E
T
VK
GY
V
Q
A
M
HQSWL
Q
DVAS
R
QST
P
A
SQS
G
L
M
NI
ETR
Y
RYNP
DVK
SL
PA
I
VP
A
VI
P
L
L
--
L
M
M
IPS
M
L
S
A
LSV
V
RE
K
E
L
G
S
I
IN
L
Y
V
T
P
T
T
RS
E
F
L
L
GK
-
---
Q
LP
Y
I
A
L
GM
L
NFF
L
L
CALSVF
V
F
GVP
HK
GS
FL
TL
T
L
AAL
LY
IIIA
TG
M
GLLIST
FMK
SQ
I
A
A
IF
G
T
A
I
I
T
L
I
PA
TQ
F
SG
MID
PV
A
S
LEGPG
R
W
I
G
E
---VY
PT
S
HF
LT
IA
R
G
T
FS
K
A
L
D
L
T
DL
W
QL
F
I
PLL
I
fig|574521.7.peg.3809
Escherichia coli O127:H6 str. E2348/69 (540-893/911)
LR
RLFS
Y
SR
R
E
A
L
E
L
R
RDP
VRSTLALMGT
V
I
L
M
L
I
M
G
Y
GI
S
M
---------
D
V
E
N
L
R
F
A
V
L
D
R
DQ
TVS
S
QAW
T
LN
L
S
G
SRY
F
IEQ
P
P
L
T
S
Y
DE
L
D
RR
M
R
V
G
DI
T
V
AI
E
IPPNF
G
R
--
D
IAR
G
T
P
V
E
L
G
V
W
I
DG
AMP
S
R
A
E
T
VK
GY
V
Q
A
M
HQSWL
Q
DVAS
R
QST
P
A
SQS
G
L
M
NI
ETR
Y
RYNP
DVK
SL
PA
I
VP
A
VI
P
L
L
--
L
M
M
IPS
M
L
S
A
LSV
V
RE
K
E
L
G
S
I
IN
L
Y
V
T
P
T
T
RS
E
F
L
L
GK
-
---
Q
LP
Y
I
A
L
GM
L
NFF
L
L
CALSVF
V
F
GVP
HK
GS
FL
TL
T
L
AAL
LY
IIIA
TG
M
GLLIST
FMK
SQ
I
A
A
IF
G
T
A
I
I
T
L
I
PA
TQ
F
SG
MID
PV
A
S
LEGPG
R
W
I
G
E
---VY
PT
S
HF
LT
IA
R
G
T
FS
K
A
L
D
L
T
DL
W
QL
F
I
PLL
I
fig|685038.3.peg.3532
Escherichia coli O83:H1 str. NRG 857C (540-893/911)
LR
RLFS
Y
SR
R
E
A
L
E
L
R
RDP
VRSTLALMGT
V
I
L
M
L
I
M
G
Y
GI
S
M
---------
D
V
E
N
L
R
F
A
V
L
D
R
DQ
TVS
S
QAW
T
LN
L
S
G
SRY
F
IEQ
P
P
L
T
S
Y
DE
L
D
RR
M
R
AG
DI
T
V
AI
E
IPPNF
G
R
--
D
IAR
G
T
P
V
E
L
G
V
W
I
DG
AMP
S
R
A
E
T
VK
GY
V
Q
A
M
HQSWL
Q
DVAS
R
QST
P
A
SQS
G
L
M
NI
ETR
Y
RYNP
DVK
SL
PA
I
VP
A
VI
P
L
L
--
L
M
M
IPS
M
L
S
A
LSV
V
RE
K
E
L
G
S
I
IN
L
Y
V
T
P
T
T
RS
E
F
L
L
GK
-
---
Q
LP
Y
I
A
L
GM
L
NFF
L
L
CALSVF
V
F
GVP
HK
GS
FL
TL
T
L
AAL
LY
IIIA
TG
M
GLLIST
FMK
SQ
I
A
A
IF
G
T
A
I
I
T
L
I
PA
TQ
F
SG
MID
PV
A
S
LEGPG
R
W
I
G
E
---VY
PT
S
HF
LT
IA
R
G
T
FS
K
A
L
D
L
T
DL
W
QL
F
I
PLL
I
fig|585035.6.peg.3817
Escherichia coli S88 (540-893/911)
LR
RLFS
Y
SR
R
E
A
L
E
L
R
RDP
VRSTLALMGT
V
I
L
M
L
I
M
G
Y
GI
S
M
---------
D
V
E
N
L
R
F
A
V
L
D
R
DQ
TVS
S
QAW
T
LN
L
S
G
SRY
F
IEQ
P
P
L
T
S
Y
DE
L
D
RR
M
R
AG
DI
T
V
AI
E
IPPNF
G
R
--
D
IAR
G
T
P
V
E
L
G
V
W
I
DG
AMP
S
R
A
E
T
VK
GY
V
Q
A
M
HQSWL
Q
DVAS
R
QST
P
A
SQS
G
L
M
NI
ETR
Y
RYNP
DVK
SL
PA
I
VP
A
VI
P
L
L
--
L
M
M
IPS
M
L
S
A
LSV
V
RE
K
E
L
G
S
I
IN
L
Y
V
T
P
T
T
RS
E
F
L
L
GK
-
---
Q
LP
Y
I
A
L
GM
L
NFF
L
L
CALSVF
V
F
GVP
HK
GS
FL
TL
T
L
AAL
LY
IIIA
TG
M
GLLIST
FMK
SQ
I
A
A
IF
G
T
A
I
I
T
L
I
PA
TQ
F
SG
MID
PV
A
S
LEGPG
R
W
I
G
E
---VY
PT
S
HF
LT
IA
R
G
T
FS
K
A
L
D
L
T
DL
W
QL
F
I
PLL
I
fig|431946.3.peg.3450
Escherichia coli SE15 (540-893/911)
LR
RLFS
Y
SR
R
E
A
L
E
L
R
RDP
VRSTLALMGT
V
I
L
M
L
I
M
G
Y
GI
S
M
---------
D
V
E
N
L
R
F
A
V
L
D
R
DQ
TVS
S
QAW
T
LN
L
S
G
SRY
F
IEQ
P
P
L
T
S
Y
DE
L
D
RR
M
R
AG
DI
T
V
AI
E
IPPNF
G
R
--
D
IAR
G
T
P
V
E
L
G
V
W
I
DG
AMP
S
R
A
E
T
VK
GY
V
Q
A
M
HQSWL
Q
DVAS
R
QST
P
A
SQS
G
L
M
NI
ETR
Y
RYNP
DVK
SL
PA
I
VP
A
VI
P
L
L
--
L
M
M
IPS
M
L
S
A
LSV
V
RE
K
E
L
G
S
I
IN
L
Y
V
T
P
T
T
RS
E
F
L
L
GK
-
---
Q
LP
Y
I
A
L
GM
L
NFF
L
L
CALSVF
V
F
GVP
HK
GS
FL
TL
T
L
AAL
LY
IIIA
TG
M
GLLIST
FMK
SQ
I
A
A
IF
G
T
A
I
I
T
L
I
PA
TQ
F
SG
MID
PV
A
S
LEGPG
R
W
I
G
E
---VY
PT
S
HF
LT
IA
R
G
T
FS
K
A
L
D
L
T
DL
W
QL
F
I
PLL
I
fig|869729.3.peg.3757
Escherichia coli UM146 (540-893/911)
LR
RLFS
Y
SR
R
E
A
L
E
L
R
RDP
VRSTLALMGT
V
I
L
M
L
I
M
G
Y
GI
S
M
---------
D
V
E
N
L
R
F
A
V
L
D
R
DQ
TVS
S
QAW
T
LN
L
S
G
SRY
F
IEQ
P
P
L
T
S
Y
DE
L
D
RR
M
R
AG
DI
T
V
AI
E
IPPNF
G
R
--
D
IAR
G
T
P
V
E
L
G
V
W
I
DG
AMP
S
R
A
E
T
VK
GY
V
Q
A
M
HQSWL
Q
DVAS
R
QST
P
A
SQS
G
L
M
NI
ETR
Y
RYNP
DVK
SL
PA
I
VP
A
VI
P
L
L
--
L
M
M
IPS
M
L
S
A
LSV
V
RE
K
E
L
G
S
I
IN
L
Y
V
T
P
T
T
RS
E
F
L
L
GK
-
---
Q
LP
Y
I
A
L
GM
L
NFF
L
L
CALSVF
V
F
GVP
HK
GS
FL
TL
T
L
AAL
LY
IIIA
TG
M
GLLIST
FMK
SQ
I
A
A
IF
G
T
A
I
I
T
L
I
PA
TQ
F
SG
MID
PV
A
S
LEGPG
R
W
I
G
E
---VY
PT
S
HF
LT
IA
R
G
T
FS
K
A
L
D
L
T
DL
W
QL
F
I
PLL
I
fig|364106.7.peg.3922
Escherichia coli UTI89 (540-893/911)
LR
RLFS
Y
SR
R
E
A
L
E
L
R
RDP
VRSTLALMGT
V
I
L
M
L
I
M
G
Y
GI
S
M
---------
D
V
E
N
L
R
F
A
V
L
D
R
DQ
TVS
S
QAW
T
LN
L
S
G
SRY
F
IEQ
P
P
L
T
S
Y
DE
L
D
RR
M
R
AG
DI
T
V
AI
E
IPPNF
G
R
--
D
IAR
G
T
P
V
E
L
G
V
W
I
DG
AMP
S
R
A
E
T
VK
GY
V
Q
A
M
HQSWL
Q
DVAS
R
QST
P
A
SQS
G
L
M
NI
ETR
Y
RYNP
DVK
SL
PA
I
VP
A
VI
P
L
L
--
L
M
M
IPS
M
L
S
A
LSV
V
RE
K
E
L
G
S
I
IN
L
Y
V
T
P
T
T
RS
E
F
L
L
GK
-
---
Q
LP
Y
I
A
L
GM
L
NFF
L
L
CALSVF
V
F
GVP
HK
GS
FL
TL
T
L
AAL
LY
IIIA
TG
M
GLLIST
FMK
SQ
I
A
A
IF
G
T
A
I
I
T
L
I
PA
TQ
F
SG
MID
PV
A
S
LEGPG
R
W
I
G
E
---VY
PT
S
HF
LT
IA
R
G
T
FS
K
A
L
D
L
T
DL
W
QL
F
I
PLL
I
fig|364106.8.peg.3923
Escherichia coli UTI89 (540-893/911)
LR
RLFS
Y
SR
R
E
A
L
E
L
R
RDP
VRSTLALMGT
V
I
L
M
L
I
M
G
Y
GI
S
M
---------
D
V
E
N
L
R
F
A
V
L
D
R
DQ
TVS
S
QAW
T
LN
L
S
G
SRY
F
IEQ
P
P
L
T
S
Y
DE
L
D
RR
M
R
AG
DI
T
V
AI
E
IPPNF
G
R
--
D
IAR
G
T
P
V
E
L
G
V
W
I
DG
AMP
S
R
A
E
T
VK
GY
V
Q
A
M
HQSWL
Q
DVAS
R
QST
P
A
SQS
G
L
M
NI
ETR
Y
RYNP
DVK
SL
PA
I
VP
A
VI
P
L
L
--
L
M
M
IPS
M
L
S
A
LSV
V
RE
K
E
L
G
S
I
IN
L
Y
V
T
P
T
T
RS
E
F
L
L
GK
-
---
Q
LP
Y
I
A
L
GM
L
NFF
L
L
CALSVF
V
F
GVP
HK
GS
FL
TL
T
L
AAL
LY
IIIA
TG
M
GLLIST
FMK
SQ
I
A
A
IF
G
T
A
I
I
T
L
I
PA
TQ
F
SG
MID
PV
A
S
LEGPG
R
W
I
G
E
---VY
PT
S
HF
LT
IA
R
G
T
FS
K
A
L
D
L
T
DL
W
QL
F
I
PLL
I
fig|585057.4.peg.4106
Escherichia coli IAI39 (540-893/911)
LR
RLFS
Y
SR
R
E
A
L
E
L
R
RDP
VRSTLALMGT
V
I
L
M
L
I
M
G
Y
GI
S
M
---------
D
V
E
N
L
R
F
A
V
L
D
R
DQ
TVS
S
QAW
T
LN
L
S
G
SRY
F
IEQ
P
P
L
T
S
Y
DE
L
D
RR
M
R
AG
DI
T
V
AI
E
IPPNF
G
R
--
D
IAR
G
T
P
V
E
L
G
V
W
I
DG
AMP
S
R
A
E
T
VK
GY
V
Q
A
M
HQSWL
Q
DVAS
R
QST
P
S
SQS
G
L
M
NI
ETR
Y
RYNP
D
I
K
SL
PA
I
VP
A
VI
P
L
L
--
L
M
M
IPS
M
L
S
A
LSV
V
RE
K
E
L
G
S
I
IN
L
Y
V
T
P
T
T
RS
E
F
L
L
GK
-
---
Q
LP
Y
I
A
L
GM
L
NFF
L
L
CGLSVF
V
F
GVP
HK
GS
FL
TL
T
L
AAL
LY
IIIA
TG
M
GLLIST
FMK
SQ
I
A
A
IF
G
T
A
I
I
T
L
I
PA
TQ
F
SG
MID
PV
A
S
LEGPG
R
W
I
G
E
---VY
PT
S
HF
LT
IA
R
G
T
FS
K
A
L
D
L
T
DL
W
QL
F
I
PLL
I
fig|585057.6.peg.4114
Escherichia coli IAI39 (540-893/911)
LR
RLFS
Y
SR
R
E
A
L
E
L
R
RDP
VRSTLALMGT
V
I
L
M
L
I
M
G
Y
GI
S
M
---------
D
V
E
N
L
R
F
A
V
L
D
R
DQ
TVS
S
QAW
T
LN
L
S
G
SRY
F
IEQ
P
P
L
T
S
Y
DE
L
D
RR
M
R
AG
DI
T
V
AI
E
IPPNF
G
R
--
D
IAR
G
T
P
V
E
L
G
V
W
I
DG
AMP
S
R
A
E
T
VK
GY
V
Q
A
M
HQSWL
Q
DVAS
R
QST
P
S
SQS
G
L
M
NI
ETR
Y
RYNP
D
I
K
SL
PA
I
VP
A
VI
P
L
L
--
L
M
M
IPS
M
L
S
A
LSV
V
RE
K
E
L
G
S
I
IN
L
Y
V
T
P
T
T
RS
E
F
L
L
GK
-
---
Q
LP
Y
I
A
L
GM
L
NFF
L
L
CGLSVF
V
F
GVP
HK
GS
FL
TL
T
L
AAL
LY
IIIA
TG
M
GLLIST
FMK
SQ
I
A
A
IF
G
T
A
I
I
T
L
I
PA
TQ
F
SG
MID
PV
A
S
LEGPG
R
W
I
G
E
---VY
PT
S
HF
LT
IA
R
G
T
FS
K
A
L
D
L
T
DL
W
QL
F
I
PLL
I
fig|550677.3.peg.4035
Escherichia coli B354 (540-893/911)
LR
RLFS
Y
SR
R
E
A
L
E
L
R
RDP
VRSTLALMGT
V
I
L
M
L
I
M
G
Y
GI
S
M
---------
D
V
E
N
L
R
F
A
V
L
D
R
DQ
TVS
S
QAW
T
LN
L
S
G
SRY
F
IEQ
P
P
L
T
S
Y
DE
L
D
RR
M
R
AG
DI
T
V
AI
E
IPPNF
G
R
--
D
IAR
G
T
P
V
E
L
G
V
W
I
DG
AMP
S
R
A
E
T
VK
GY
V
Q
A
M
HQSWL
Q
DVAS
R
QST
P
S
SQS
G
L
M
NI
ETR
Y
RYNP
DVK
SL
PA
I
VP
A
VI
P
L
L
--
L
M
M
IPS
M
L
S
A
LSV
V
RE
K
E
L
G
S
I
IN
L
Y
V
T
P
T
T
RS
E
F
L
L
GK
-
---
Q
LP
Y
I
A
L
GM
L
NFF
L
L
CGLSVF
V
F
GVP
HK
GS
FL
TL
T
L
AAL
LY
IIIA
TG
M
GLLIST
FMK
SQ
I
A
A
IF
G
T
A
I
I
T
L
I
PA
TQ
F
SG
MID
PV
A
S
LEGPG
R
W
I
G
E
---VY
PT
S
HF
LT
IA
R
G
T
FS
K
A
L
D
L
T
DL
W
QL
F
I
PLL
I
fig|656379.3.peg.4787
Escherichia coli FVEC1302 (540-893/911)
LR
RLFS
Y
SR
R
E
A
L
E
L
R
RDP
VRSTLALMGT
V
I
L
M
L
I
M
G
Y
GI
S
M
---------
D
V
E
N
L
R
F
A
V
L
D
R
DQ
TVS
S
QAW
T
LN
L
S
G
SRY
F
IEQ
P
P
L
T
S
Y
DE
L
D
RR
M
R
AG
DI
T
V
AI
E
IPPNF
G
R
--
D
IAR
G
T
P
V
E
L
G
V
W
I
DG
AMP
S
R
A
E
T
VK
GY
V
Q
A
M
HQSWL
Q
DVAS
R
QST
P
S
SQS
G
L
M
NI
ETR
Y
RYNP
DVK
SL
PA
I
VP
A
VI
P
L
L
--
L
M
M
IPS
M
L
S
A
LSV
V
RE
K
E
L
G
S
I
IN
L
Y
V
T
P
T
T
RS
E
F
L
L
GK
-
---
Q
LP
Y
I
A
L
GM
L
NFF
L
L
CGLSVF
V
F
GVP
HK
GS
FL
TL
T
L
AAL
LY
IIIA
TG
M
GLLIST
FMK
SQ
I
A
A
IF
G
T
A
I
I
T
L
I
PA
TQ
F
SG
MID
PV
A
S
LEGPG
R
W
I
G
E
---VY
PT
S
HF
LT
IA
R
G
T
FS
K
A
L
D
L
T
DL
W
QL
F
I
PLL
I
fig|656380.3.peg.4577
Escherichia coli FVEC1412 (540-893/911)
LR
RLFS
Y
SR
R
E
A
L
E
L
R
RDP
VRSTLALMGT
V
I
L
M
L
I
M
G
Y
GI
S
M
---------
D
V
E
N
L
R
F
A
V
L
D
R
DQ
TVS
S
QAW
T
LN
L
S
G
SRY
F
IEQ
P
P
L
T
S
Y
DE
L
D
RR
M
R
AG
DI
T
V
AI
E
IPPNF
G
R
--
D
IAR
G
T
P
V
E
L
G
V
W
I
DG
AMP
S
R
A
E
T
VK
GY
V
Q
A
M
HQSWL
Q
DVAS
R
QST
P
S
SQS
G
L
M
NI
ETR
Y
RYNP
DVK
SL
PA
I
VP
A
VI
P
L
L
--
L
M
M
IPS
M
L
S
A
LSV
V
RE
K
E
L
G
S
I
IN
L
Y
V
T
P
T
T
RS
E
F
L
L
GK
-
---
Q
LP
Y
I
A
L
GM
L
NFF
L
L
CGLSVF
V
F
GVP
HK
GS
FL
TL
T
L
AAL
LY
IIIA
TG
M
GLLIST
FMK
SQ
I
A
A
IF
G
T
A
I
I
T
L
I
PA
TQ
F
SG
MID
PV
A
S
LEGPG
R
W
I
G
E
---VY
PT
S
HF
LT
IA
R
G
T
FS
K
A
L
D
L
T
DL
W
QL
F
I
PLL
I
fig|749549.3.peg.2760
Escherichia coli MS 198-1 (540-893/911)
LR
RLFS
Y
SR
R
E
A
L
E
L
R
RDP
VRSTLALMGT
V
I
L
M
L
I
M
G
Y
GI
S
M
---------
D
V
E
N
L
R
F
A
V
L
D
R
DQ
TVS
S
QAW
T
LN
L
S
G
SRY
F
IEQ
P
P
L
T
S
Y
DE
L
D
RR
M
R
AG
DI
T
V
AI
E
IPPNF
G
R
--
D
IAR
G
T
P
V
E
L
G
V
W
I
DG
AMP
S
R
A
E
T
VK
GY
V
Q
A
M
HQSWL
Q
DVAS
R
QST
P
S
SQS
G
L
M
NI
ETR
Y
RYNP
DVK
SL
PA
I
VP
A
VI
P
L
L
--
L
M
M
IPS
M
L
S
A
LSV
V
RE
K
E
L
G
S
I
IN
L
Y
V
T
P
T
T
RS
E
F
L
L
GK
-
---
Q
LP
Y
I
A
L
GM
L
NFF
L
L
CGLSVF
V
F
GVP
HK
GS
FL
TL
T
L
AAL
LY
IIIA
TG
M
GLLIST
FMK
SQ
I
A
A
IF
G
T
A
I
I
T
L
I
PA
TQ
F
SG
MID
PV
A
S
LEGPG
R
W
I
G
E
---VY
PT
S
HF
LT
IA
R
G
T
FS
K
A
L
D
L
T
DL
W
QL
F
I
PLL
I
fig|749531.3.peg.1588
Escherichia coli MS 69-1 (540-893/911)
LR
RLFS
Y
SR
R
E
A
L
E
L
R
RDP
VRSTLALMGT
V
I
L
M
L
I
M
G
Y
GI
S
M
---------
D
V
E
N
L
R
F
A
V
L
D
R
DQ
TVS
S
QAW
T
LN
L
S
G
SRY
F
IEQ
P
P
L
T
S
Y
DE
L
D
RR
M
R
AG
DI
T
V
AI
E
IPPNF
G
R
--
D
IAR
G
T
P
V
E
L
G
V
W
I
DG
AMP
S
R
A
E
T
VK
GY
V
Q
A
M
HQSWL
Q
DVAS
R
QST
P
S
SQS
G
L
M
NI
ETR
Y
RYNP
DVK
SL
PA
I
VP
A
VI
P
L
L
--
L
M
M
IPS
M
L
S
A
LSV
V
RE
K
E
L
G
S
I
IN
L
Y
V
T
P
T
T
RS
E
F
L
L
GK
-
---
Q
LP
Y
I
A
L
GM
L
NFF
L
L
CGLSVF
V
F
GVP
HK
GS
FL
TL
T
L
AAL
LY
IIIA
TG
M
GLLIST
FMK
SQ
I
A
A
IF
G
T
A
I
I
T
L
I
PA
TQ
F
SG
MID
PV
A
S
LEGPG
R
W
I
G
E
---VY
PT
S
HF
LT
IA
R
G
T
FS
K
A
L
D
L
T
DL
W
QL
F
I
PLL
I
fig|656437.3.peg.3909
Escherichia coli TA143 (540-893/911)
LR
RLFS
Y
SR
R
E
A
L
E
L
R
RDP
VRSTLALMGT
V
I
L
M
L
I
M
G
Y
GI
S
M
---------
D
V
E
N
L
R
F
A
V
L
D
R
DQ
TVS
S
QAW
T
LN
L
S
G
SRY
F
IEQ
P
P
L
T
S
Y
DE
L
D
RR
M
R
AG
DI
T
V
AI
E
IPPNF
G
R
--
D
IAR
G
T
P
V
E
L
G
V
W
I
DG
AMP
S
R
A
E
T
VK
GY
V
Q
A
M
HQSWL
Q
DVAS
R
QST
P
S
SQS
G
L
M
NI
ETR
Y
RYNP
DVK
SL
PA
I
VP
A
VI
P
L
L
--
L
M
M
IPS
M
L
S
A
LSV
V
RE
K
E
L
G
S
I
IN
L
Y
V
T
P
T
T
RS
E
F
L
L
GK
-
---
Q
LP
Y
I
A
L
GM
L
NFF
L
L
CGLSVF
V
F
GVP
HK
GS
FL
TL
T
L
AAL
LY
IIIA
TG
M
GLLIST
FMK
SQ
I
A
A
IF
G
T
A
I
I
T
L
I
PA
TQ
F
SG
MID
PV
A
S
LEGPG
R
W
I
G
E
---VY
PT
S
HF
LT
IA
R
G
T
FS
K
A
L
D
L
T
DL
W
QL
F
I
PLL
I
fig|585056.7.peg.4145
Escherichia coli UMN026 (540-893/911)
LR
RLFS
Y
SR
R
E
A
L
E
L
R
RDP
VRSTLALMGT
V
I
L
M
L
I
M
G
Y
GI
S
M
---------
D
V
E
N
L
R
F
A
V
L
D
R
DQ
TVS
S
QAW
T
LN
L
S
G
SRY
F
IEQ
P
P
L
T
S
Y
DE
L
D
RR
M
R
AG
DI
T
V
AI
E
IPPNF
G
R
--
D
IAR
G
T
P
V
E
L
G
V
W
I
DG
AMP
S
R
A
E
T
VK
GY
V
Q
A
M
HQSWL
Q
DVAS
R
QST
P
S
SQS
G
L
M
NI
ETR
Y
RYNP
DVK
SL
PA
I
VP
A
VI
P
L
L
--
L
M
M
IPS
M
L
S
A
LSV
V
RE
K
E
L
G
S
I
IN
L
Y
V
T
P
T
T
RS
E
F
L
L
GK
-
---
Q
LP
Y
I
A
L
GM
L
NFF
L
L
CGLSVF
V
F
GVP
HK
GS
FL
TL
T
L
AAL
LY
IIIA
TG
M
GLLIST
FMK
SQ
I
A
A
IF
G
T
A
I
I
T
L
I
PA
TQ
F
SG
MID
PV
A
S
LEGPG
R
W
I
G
E
---VY
PT
S
HF
LT
IA
R
G
T
FS
K
A
L
D
L
T
DL
W
QL
F
I
PLL
I
fig|216592.1.peg.735
Escherichia coli 042 (540-893/911)
LR
RLFS
Y
SR
R
E
A
L
E
L
R
RDP
VRSTLALMGT
V
I
L
M
L
I
M
G
Y
GI
S
M
---------
D
V
E
N
L
R
F
A
V
L
D
R
DQ
TVS
S
QAW
T
LN
L
S
G
SRY
F
IEQ
P
P
L
T
S
Y
DE
L
D
RR
M
R
AG
DI
T
V
AI
E
IPPNF
G
R
--
D
IAR
G
T
P
V
E
L
G
V
W
I
DG
AMP
S
R
A
E
T
VK
GY
V
Q
A
M
HQSWL
Q
DVAS
R
QST
P
S
SQS
G
L
M
NI
ETR
Y
RYNP
DVK
SL
PA
I
VP
A
VI
P
L
L
--
L
M
M
IPS
M
L
S
A
LSV
V
RE
K
E
L
G
S
I
IN
L
Y
V
T
P
T
T
RS
E
F
L
L
GK
-
---
Q
LP
Y
I
A
L
GM
L
NFF
L
L
CGLSVF
V
F
GVP
HK
GS
FL
TL
T
L
AAL
LY
IIIA
TG
M
GLLIST
FMK
SQ
I
A
A
IF
G
T
A
I
I
T
L
I
PA
TQ
F
SG
MID
PV
A
S
LEGPG
R
W
I
G
E
---VY
PT
S
HF
LT
IA
R
G
T
FS
K
A
L
D
L
T
DL
W
QL
F
I
PLL
I
fig|216592.3.peg.3914
Escherichia coli 042 (540-893/911)
LR
RLFS
Y
SR
R
E
A
L
E
L
R
RDP
VRSTLALMGT
V
I
L
M
L
I
M
G
Y
GI
S
M
---------
D
V
E
N
L
R
F
A
V
L
D
R
DQ
TVS
S
QAW
T
LN
L
S
G
SRY
F
IEQ
P
P
L
T
S
Y
DE
L
D
RR
M
R
AG
DI
T
V
AI
E
IPPNF
G
R
--
D
IAR
G
T
P
V
E
L
G
V
W
I
DG
AMP
S
R
A
E
T
VK
GY
V
Q
A
M
HQSWL
Q
DVAS
R
QST
P
S
SQS
G
L
M
NI
ETR
Y
RYNP
DVK
SL
PA
I
VP
A
VI
P
L
L
--
L
M
M
IPS
M
L
S
A
LSV
V
RE
K
E
L
G
S
I
IN
L
Y
V
T
P
T
T
RS
E
F
L
L
GK
-
---
Q
LP
Y
I
A
L
GM
L
NFF
L
L
CGLSVF
V
F
GVP
HK
GS
FL
TL
T
L
AAL
LY
IIIA
TG
M
GLLIST
FMK
SQ
I
A
A
IF
G
T
A
I
I
T
L
I
PA
TQ
F
SG
MID
PV
A
S
LEGPG
R
W
I
G
E
---VY
PT
S
HF
LT
IA
R
G
T
FS
K
A
L
D
L
T
DL
W
QL
F
I
PLL
I
fig|656419.3.peg.4485
Escherichia coli M718 (540-893/911)
LR
RLFS
Y
SR
R
E
A
L
E
L
R
RDP
VRSTLALMGT
V
I
L
M
L
I
M
G
Y
GI
S
M
---------
D
V
E
N
L
R
F
A
V
L
D
R
DQ
TVS
S
QAW
T
LN
L
S
G
SRY
F
IEQ
P
P
L
T
S
Y
DE
L
D
RR
M
R
AG
DI
T
V
AI
E
IPPNF
G
R
--
D
IAR
G
T
P
V
E
L
G
V
W
I
DG
AMP
S
R
A
E
T
VK
GY
V
Q
A
M
HQSWL
Q
DVAS
R
QST
P
S
SQS
G
L
M
NI
ETR
Y
RYNP
DVK
SL
PA
I
VP
A
VI
P
L
L
--
L
M
M
IPS
M
L
S
A
LSV
V
RE
K
E
L
G
S
I
IN
L
Y
V
T
P
T
T
RS
E
F
L
L
GK
-
---
Q
LP
Y
I
A
L
GM
L
NFF
L
L
CGLSVF
V
F
GVP
HK
GS
FL
TL
T
L
AAL
LY
IIIA
TG
M
GLLIST
FMK
SQ
I
A
A
IF
G
T
A
I
I
T
L
I
PA
TQ
F
SG
MID
PV
A
S
LEGPG
R
W
I
G
E
---VY
PT
S
HF
LT
IA
R
G
T
FS
K
A
L
D
L
A
DL
W
QL
F
I
PLL
I
fig|749527.3.peg.1358
Escherichia coli MS 21-1 (540-893/911)
LR
RLFS
Y
SR
R
E
A
L
E
L
R
RDP
VRSTLALMGT
V
I
L
M
L
I
M
G
Y
GI
S
M
---------
D
V
E
N
L
R
F
A
V
L
D
R
DQ
TVS
S
QAW
T
LN
L
S
G
SRY
F
IEQ
P
P
L
T
S
Y
DE
L
D
RR
M
R
AG
DI
T
V
AI
E
IPPNF
G
R
--
D
IAR
G
T
P
V
E
L
G
V
W
I
DG
AMP
S
R
A
E
T
VK
GY
V
Q
A
M
HQSWL
Q
DVAS
R
QST
P
A
SQS
G
L
M
NI
ETR
Y
RYNP
DVK
SL
PA
I
VP
A
VI
P
L
L
--
L
M
M
IPS
M
L
S
A
LSV
V
RE
K
E
L
G
S
I
IN
L
Y
V
T
P
T
T
RS
E
F
L
L
GK
-
---
Q
LP
Y
I
G
L
GM
L
NFF
L
L
CALSVF
V
F
GVP
HK
GS
FL
TL
T
L
AAL
LY
IIIA
TG
M
GLLIST
FMK
SQ
I
A
A
IF
G
T
A
I
I
T
L
I
PA
TQ
F
SG
MID
PV
A
S
LEGPG
R
W
I
G
E
---VY
PT
S
HF
LT
IA
R
G
T
FS
K
A
L
D
L
T
DL
W
QL
F
I
PLL
I
fig|439855.10.peg.3922
Escherichia coli SMS-3-5 (540-893/911)
LR
RLFS
Y
SR
R
E
A
L
E
L
R
RDP
VRSTLALMGT
V
I
L
M
L
I
M
G
Y
GI
S
M
---------
D
V
E
N
L
R
F
A
V
L
D
R
DQ
TVS
S
QAW
T
LN
L
S
G
SRY
F
IEQ
P
P
L
T
S
Y
DE
L
D
RR
M
R
AG
DI
T
V
AI
E
IPPNF
G
R
--
D
IAR
G
T
P
V
E
L
G
V
W
I
DG
AMP
S
R
A
E
T
VK
GY
V
Q
A
M
HQSWL
Q
DVAS
R
QST
P
A
SQS
G
L
M
NI
ETR
Y
RYNP
DVK
SL
PA
I
VP
A
VI
P
L
L
--
L
M
M
IPS
M
L
S
A
LSV
V
RE
K
E
L
G
S
I
IN
L
Y
V
T
P
T
T
RS
E
F
L
L
GK
-
---
Q
LP
Y
I
G
L
GM
L
NFF
L
L
CALSVF
V
F
GVP
HK
GS
FL
TL
T
L
AAL
LY
IIIA
TG
M
GLLIST
FMK
SQ
I
A
A
IF
G
T
A
I
I
T
L
I
PA
TQ
F
SG
MID
PV
A
S
LEGPG
R
W
I
G
E
---VY
PT
S
HF
LT
IA
R
G
T
FS
K
A
L
D
L
T
DL
W
QL
F
I
PLL
I
fig|6666666.5357.peg.1869
Escherichia coli TY-2482 (277-630/648)
LR
RLFS
Y
SR
R
E
A
L
E
L
R
RDP
VRSTLALMGT
V
I
L
M
L
I
M
G
Y
GI
S
M
---------
D
V
E
N
L
R
F
A
V
L
D
R
DQ
TVS
S
QAW
T
LN
L
S
G
SRY
F
IEQ
P
P
L
T
S
Y
DE
L
D
RR
M
R
AG
DI
T
V
AI
E
IPPNF
G
R
--
D
IAR
G
T
P
V
E
L
G
V
W
I
DG
AMP
S
R
A
E
T
VK
GY
V
Q
A
M
HQSWL
Q
DVAS
R
QST
P
A
SQS
G
L
M
NI
ETR
Y
RYNP
DVK
SL
PA
I
VP
A
VI
P
L
L
--
L
M
M
IPS
M
L
S
A
LSV
V
RE
K
E
L
G
S
I
IN
L
Y
V
T
P
T
T
RS
E
F
L
L
GK
-
---
Q
LP
Y
I
A
L
GM
L
NFF
L
L
CGLSVF
V
F
GVP
HK
GS
FL
TL
T
L
AAL
LY
IIIA
TG
M
GLLIST
FMK
SQ
I
A
A
IF
G
T
A
I
I
T
L
I
PA
TQ
F
SG
MID
PV
A
S
LEGPG
R
W
I
G
E
---VY
PT
S
HF
LT
IA
R
G
T
FS
K
A
L
D
L
T
DL
W
QL
F
I
PLL
I
fig|637912.3.peg.4055
Escherichia coli OP50 (119-472/490)
LR
RLFS
Y
SR
R
E
A
L
E
L
R
RDP
VRSTLALMGT
V
I
L
M
L
I
M
G
Y
GI
S
M
---------
D
V
E
N
L
R
F
A
V
L
D
R
DQ
TVS
S
QAW
T
LN
L
S
G
SRY
F
IEQ
P
P
L
T
S
Y
DE
L
D
RR
M
R
AG
DI
T
V
AI
E
IPPNF
G
R
--
D
IAR
G
T
P
V
E
L
G
V
W
I
DG
AMP
S
R
A
E
T
VK
GY
V
Q
A
M
HQSWL
Q
DVAS
R
QST
P
A
SQS
G
L
M
NI
ETR
Y
RYNP
DVK
SL
PA
I
VP
A
VI
P
L
L
--
L
M
M
IPS
M
L
S
A
LSV
V
RE
K
E
L
G
S
I
IN
L
Y
V
T
P
T
T
RS
E
F
L
L
GK
-
---
Q
LP
Y
I
A
L
GM
L
NFF
L
L
CGLSVF
V
F
GVP
HK
GS
FL
TL
T
L
AAL
LY
IIIA
TG
M
GLLIST
FMK
SQ
I
A
A
IF
G
T
A
I
I
T
L
I
PA
TQ
F
SG
MID
PV
A
S
LEGPG
R
W
I
G
E
---VY
PT
S
HF
LT
IA
R
G
T
FS
K
A
L
D
L
T
DL
W
QL
F
I
PLL
I
fig|358709.5.peg.332
Escherichia coli 101-1 (540-893/911)
LR
RLFS
Y
SR
R
E
A
L
E
L
R
RDP
VRSTLALMGT
V
I
L
M
L
I
M
G
Y
GI
S
M
---------
D
V
E
N
L
R
F
A
V
L
D
R
DQ
TVS
S
QAW
T
LN
L
S
G
SRY
F
IEQ
P
P
L
T
S
Y
DE
L
D
RR
M
R
AG
DI
T
V
AI
E
IPPNF
G
R
--
D
IAR
G
T
P
V
E
L
G
V
W
I
DG
AMP
S
R
A
E
T
VK
GY
V
Q
A
M
HQSWL
Q
DVAS
R
QST
P
A
SQS
G
L
M
NI
ETR
Y
RYNP
DVK
SL
PA
I
VP
A
VI
P
L
L
--
L
M
M
IPS
M
L
S
A
LSV
V
RE
K
E
L
G
S
I
IN
L
Y
V
T
P
T
T
RS
E
F
L
L
GK
-
---
Q
LP
Y
I
A
L
GM
L
NFF
L
L
CGLSVF
V
F
GVP
HK
GS
FL
TL
T
L
AAL
LY
IIIA
TG
M
GLLIST
FMK
SQ
I
A
A
IF
G
T
A
I
I
T
L
I
PA
TQ
F
SG
MID
PV
A
S
LEGPG
R
W
I
G
E
---VY
PT
S
HF
LT
IA
R
G
T
FS
K
A
L
D
L
T
DL
W
QL
F
I
PLL
I
fig|344610.3.peg.119
Escherichia coli 53638 (540-893/911)
LR
RLFS
Y
SR
R
E
A
L
E
L
R
RDP
VRSTLALMGT
V
I
L
M
L
I
M
G
Y
GI
S
M
---------
D
V
E
N
L
R
F
A
V
L
D
R
DQ
TVS
S
QAW
T
LN
L
S
G
SRY
F
IEQ
P
P
L
T
S
Y
DE
L
D
RR
M
R
AG
DI
T
V
AI
E
IPPNF
G
R
--
D
IAR
G
T
P
V
E
L
G
V
W
I
DG
AMP
S
R
A
E
T
VK
GY
V
Q
A
M
HQSWL
Q
DVAS
R
QST
P
A
SQS
G
L
M
NI
ETR
Y
RYNP
DVK
SL
PA
I
VP
A
VI
P
L
L
--
L
M
M
IPS
M
L
S
A
LSV
V
RE
K
E
L
G
S
I
IN
L
Y
V
T
P
T
T
RS
E
F
L
L
GK
-
---
Q
LP
Y
I
A
L
GM
L
NFF
L
L
CGLSVF
V
F
GVP
HK
GS
FL
TL
T
L
AAL
LY
IIIA
TG
M
GLLIST
FMK
SQ
I
A
A
IF
G
T
A
I
I
T
L
I
PA
TQ
F
SG
MID
PV
A
S
LEGPG
R
W
I
G
E
---VY
PT
S
HF
LT
IA
R
G
T
FS
K
A
L
D
L
T
DL
W
QL
F
I
PLL
I
fig|344610.7.peg.2747
Escherichia coli 53638 (540-893/911)
LR
RLFS
Y
SR
R
E
A
L
E
L
R
RDP
VRSTLALMGT
V
I
L
M
L
I
M
G
Y
GI
S
M
---------
D
V
E
N
L
R
F
A
V
L
D
R
DQ
TVS
S
QAW
T
LN
L
S
G
SRY
F
IEQ
P
P
L
T
S
Y
DE
L
D
RR
M
R
AG
DI
T
V
AI
E
IPPNF
G
R
--
D
IAR
G
T
P
V
E
L
G
V
W
I
DG
AMP
S
R
A
E
T
VK
GY
V
Q
A
M
HQSWL
Q
DVAS
R
QST
P
A
SQS
G
L
M
NI
ETR
Y
RYNP
DVK
SL
PA
I
VP
A
VI
P
L
L
--
L
M
M
IPS
M
L
S
A
LSV
V
RE
K
E
L
G
S
I
IN
L
Y
V
T
P
T
T
RS
E
F
L
L
GK
-
---
Q
LP
Y
I
A
L
GM
L
NFF
L
L
CGLSVF
V
F
GVP
HK
GS
FL
TL
T
L
AAL
LY
IIIA
TG
M
GLLIST
FMK
SQ
I
A
A
IF
G
T
A
I
I
T
L
I
PA
TQ
F
SG
MID
PV
A
S
LEGPG
R
W
I
G
E
---VY
PT
S
HF
LT
IA
R
G
T
FS
K
A
L
D
L
T
DL
W
QL
F
I
PLL
I
fig|585055.6.peg.3923
Escherichia coli 55989 (540-893/911)
LR
RLFS
Y
SR
R
E
A
L
E
L
R
RDP
VRSTLALMGT
V
I
L
M
L
I
M
G
Y
GI
S
M
---------
D
V
E
N
L
R
F
A
V
L
D
R
DQ
TVS
S
QAW
T
LN
L
S
G
SRY
F
IEQ
P
P
L
T
S
Y
DE
L
D
RR
M
R
AG
DI
T
V
AI
E
IPPNF
G
R
--
D
IAR
G
T
P
V
E
L
G
V
W
I
DG
AMP
S
R
A
E
T
VK
GY
V
Q
A
M
HQSWL
Q
DVAS
R
QST
P
A
SQS
G
L
M
NI
ETR
Y
RYNP
DVK
SL
PA
I
VP
A
VI
P
L
L
--
L
M
M
IPS
M
L
S
A
LSV
V
RE
K
E
L
G
S
I
IN
L
Y
V
T
P
T
T
RS
E
F
L
L
GK
-
---
Q
LP
Y
I
A
L
GM
L
NFF
L
L
CGLSVF
V
F
GVP
HK
GS
FL
TL
T
L
AAL
LY
IIIA
TG
M
GLLIST
FMK
SQ
I
A
A
IF
G
T
A
I
I
T
L
I
PA
TQ
F
SG
MID
PV
A
S
LEGPG
R
W
I
G
E
---VY
PT
S
HF
LT
IA
R
G
T
FS
K
A
L
D
L
T
DL
W
QL
F
I
PLL
I
fig|585055.8.peg.3925
Escherichia coli 55989 (540-893/911)
LR
RLFS
Y
SR
R
E
A
L
E
L
R
RDP
VRSTLALMGT
V
I
L
M
L
I
M
G
Y
GI
S
M
---------
D
V
E
N
L
R
F
A
V
L
D
R
DQ
TVS
S
QAW
T
LN
L
S
G
SRY
F
IEQ
P
P
L
T
S
Y
DE
L
D
RR
M
R
AG
DI
T
V
AI
E
IPPNF
G
R
--
D
IAR
G
T
P
V
E
L
G
V
W
I
DG
AMP
S
R
A
E
T
VK
GY
V
Q
A
M
HQSWL
Q
DVAS
R
QST
P
A
SQS
G
L
M
NI
ETR
Y
RYNP
DVK
SL
PA
I
VP
A
VI
P
L
L
--
L
M
M
IPS
M
L
S
A
LSV
V
RE
K
E
L
G
S
I
IN
L
Y
V
T
P
T
T
RS
E
F
L
L
GK
-
---
Q
LP
Y
I
A
L
GM
L
NFF
L
L
CGLSVF
V
F
GVP
HK
GS
FL
TL
T
L
AAL
LY
IIIA
TG
M
GLLIST
FMK
SQ
I
A
A
IF
G
T
A
I
I
T
L
I
PA
TQ
F
SG
MID
PV
A
S
LEGPG
R
W
I
G
E
---VY
PT
S
HF
LT
IA
R
G
T
FS
K
A
L
D
L
T
DL
W
QL
F
I
PLL
I
fig|413997.3.peg.3493
Escherichia coli B str. REL606 (540-893/911)
LR
RLFS
Y
SR
R
E
A
L
E
L
R
RDP
VRSTLALMGT
V
I
L
M
L
I
M
G
Y
GI
S
M
---------
D
V
E
N
L
R
F
A
V
L
D
R
DQ
TVS
S
QAW
T
LN
L
S
G
SRY
F
IEQ
P
P
L
T
S
Y
DE
L
D
RR
M
R
AG
DI
T
V
AI
E
IPPNF
G
R
--
D
IAR
G
T
P
V
E
L
G
V
W
I
DG
AMP
S
R
A
E
T
VK
GY
V
Q
A
M
HQSWL
Q
DVAS
R
QST
P
A
SQS
G
L
M
NI
ETR
Y
RYNP
DVK
SL
PA
I
VP
A
VI
P
L
L
--
L
M
M
IPS
M
L
S
A
LSV
V
RE
K
E
L
G
S
I
IN
L
Y
V
T
P
T
T
RS
E
F
L
L
GK
-
---
Q
LP
Y
I
A
L
GM
L
NFF
L
L
CGLSVF
V
F
GVP
HK
GS
FL
TL
T
L
AAL
LY
IIIA
TG
M
GLLIST
FMK
SQ
I
A
A
IF
G
T
A
I
I
T
L
I
PA
TQ
F
SG
MID
PV
A
S
LEGPG
R
W
I
G
E
---VY
PT
S
HF
LT
IA
R
G
T
FS
K
A
L
D
L
T
DL
W
QL
F
I
PLL
I
fig|344601.3.peg.1324
Escherichia coli B171 (540-893/911)
LR
RLFS
Y
SR
R
E
A
L
E
L
R
RDP
VRSTLALMGT
V
I
L
M
L
I
M
G
Y
GI
S
M
---------
D
V
E
N
L
R
F
A
V
L
D
R
DQ
TVS
S
QAW
T
LN
L
S
G
SRY
F
IEQ
P
P
L
T
S
Y
DE
L
D
RR
M
R
AG
DI
T
V
AI
E
IPPNF
G
R
--
D
IAR
G
T
P
V
E
L
G
V
W
I
DG
AMP
S
R
A
E
T
VK
GY
V
Q
A
M
HQSWL
Q
DVAS
R
QST
P
A
SQS
G
L
M
NI
ETR
Y
RYNP
DVK
SL
PA
I
VP
A
VI
P
L
L
--
L
M
M
IPS
M
L
S
A
LSV
V
RE
K
E
L
G
S
I
IN
L
Y
V
T
P
T
T
RS
E
F
L
L
GK
-
---
Q
LP
Y
I
A
L
GM
L
NFF
L
L
CGLSVF
V
F
GVP
HK
GS
FL
TL
T
L
AAL
LY
IIIA
TG
M
GLLIST
FMK
SQ
I
A
A
IF
G
T
A
I
I
T
L
I
PA
TQ
F
SG
MID
PV
A
S
LEGPG
R
W
I
G
E
---VY
PT
S
HF
LT
IA
R
G
T
FS
K
A
L
D
L
T
DL
W
QL
F
I
PLL
I
fig|344601.5.peg.1392
Escherichia coli B171 (540-893/911)
LR
RLFS
Y
SR
R
E
A
L
E
L
R
RDP
VRSTLALMGT
V
I
L
M
L
I
M
G
Y
GI
S
M
---------
D
V
E
N
L
R
F
A
V
L
D
R
DQ
TVS
S
QAW
T
LN
L
S
G
SRY
F
IEQ
P
P
L
T
S
Y
DE
L
D
RR
M
R
AG
DI
T
V
AI
E
IPPNF
G
R
--
D
IAR
G
T
P
V
E
L
G
V
W
I
DG
AMP
S
R
A
E
T
VK
GY
V
Q
A
M
HQSWL
Q
DVAS
R
QST
P
A
SQS
G
L
M
NI
ETR
Y
RYNP
DVK
SL
PA
I
VP
A
VI
P
L
L
--
L
M
M
IPS
M
L
S
A
LSV
V
RE
K
E
L
G
S
I
IN
L
Y
V
T
P
T
T
RS
E
F
L
L
GK
-
---
Q
LP
Y
I
A
L
GM
L
NFF
L
L
CGLSVF
V
F
GVP
HK
GS
FL
TL
T
L
AAL
LY
IIIA
TG
M
GLLIST
FMK
SQ
I
A
A
IF
G
T
A
I
I
T
L
I
PA
TQ
F
SG
MID
PV
A
S
LEGPG
R
W
I
G
E
---VY
PT
S
HF
LT
IA
R
G
T
FS
K
A
L
D
L
T
DL
W
QL
F
I
PLL
I
fig|550676.3.peg.3643
Escherichia coli B185 (540-893/911)
LR
RLFS
Y
SR
R
E
A
L
E
L
R
RDP
VRSTLALMGT
V
I
L
M
L
I
M
G
Y
GI
S
M
---------
D
V
E
N
L
R
F
A
V
L
D
R
DQ
TVS
S
QAW
T
LN
L
S
G
SRY
F
IEQ
P
P
L
T
S
Y
DE
L
D
RR
M
R
AG
DI
T
V
AI
E
IPPNF
G
R
--
D
IAR
G
T
P
V
E
L
G
V
W
I
DG
AMP
S
R
A
E
T
VK
GY
V
Q
A
M
HQSWL
Q
DVAS
R
QST
P
A
SQS
G
L
M
NI
ETR
Y
RYNP
DVK
SL
PA
I
VP
A
VI
P
L
L
--
L
M
M
IPS
M
L
S
A
LSV
V
RE
K
E
L
G
S
I
IN
L
Y
V
T
P
T
T
RS
E
F
L
L
GK
-
---
Q
LP
Y
I
A
L
GM
L
NFF
L
L
CGLSVF
V
F
GVP
HK
GS
FL
TL
T
L
AAL
LY
IIIA
TG
M
GLLIST
FMK
SQ
I
A
A
IF
G
T
A
I
I
T
L
I
PA
TQ
F
SG
MID
PV
A
S
LEGPG
R
W
I
G
E
---VY
PT
S
HF
LT
IA
R
G
T
FS
K
A
L
D
L
T
DL
W
QL
F
I
PLL
I
fig|340184.3.peg.372
Escherichia coli B7A (540-893/911)
LR
RLFS
Y
SR
R
E
A
L
E
L
R
RDP
VRSTLALMGT
V
I
L
M
L
I
M
G
Y
GI
S
M
---------
D
V
E
N
L
R
F
A
V
L
D
R
DQ
TVS
S
QAW
T
LN
L
S
G
SRY
F
IEQ
P
P
L
T
S
Y
DE
L
D
RR
M
R
AG
DI
T
V
AI
E
IPPNF
G
R
--
D
IAR
G
T
P
V
E
L
G
V
W
I
DG
AMP
S
R
A
E
T
VK
GY
V
Q
A
M
HQSWL
Q
DVAS
R
QST
P
A
SQS
G
L
M
NI
ETR
Y
RYNP
DVK
SL
PA
I
VP
A
VI
P
L
L
--
L
M
M
IPS
M
L
S
A
LSV
V
RE
K
E
L
G
S
I
IN
L
Y
V
T
P
T
T
RS
E
F
L
L
GK
-
---
Q
LP
Y
I
A
L
GM
L
NFF
L
L
CGLSVF
V
F
GVP
HK
GS
FL
TL
T
L
AAL
LY
IIIA
TG
M
GLLIST
FMK
SQ
I
A
A
IF
G
T
A
I
I
T
L
I
PA
TQ
F
SG
MID
PV
A
S
LEGPG
R
W
I
G
E
---VY
PT
S
HF
LT
IA
R
G
T
FS
K
A
L
D
L
T
DL
W
QL
F
I
PLL
I
fig|340184.6.peg.391
Escherichia coli B7A (540-893/911)
LR
RLFS
Y
SR
R
E
A
L
E
L
R
RDP
VRSTLALMGT
V
I
L
M
L
I
M
G
Y
GI
S
M
---------
D
V
E
N
L
R
F
A
V
L
D
R
DQ
TVS
S
QAW
T
LN
L
S
G
SRY
F
IEQ
P
P
L
T
S
Y
DE
L
D
RR
M
R
AG
DI
T
V
AI
E
IPPNF
G
R
--
D
IAR
G
T
P
V
E
L
G
V
W
I
DG
AMP
S
R
A
E
T
VK
GY
V
Q
A
M
HQSWL
Q
DVAS
R
QST
P
A
SQS
G
L
M
NI
ETR
Y
RYNP
DVK
SL
PA
I
VP
A
VI
P
L
L
--
L
M
M
IPS
M
L
S
A
LSV
V
RE
K
E
L
G
S
I
IN
L
Y
V
T
P
T
T
RS
E
F
L
L
GK
-
---
Q
LP
Y
I
A
L
GM
L
NFF
L
L
CGLSVF
V
F
GVP
HK
GS
FL
TL
T
L
AAL
LY
IIIA
TG
M
GLLIST
FMK
SQ
I
A
A
IF
G
T
A
I
I
T
L
I
PA
TQ
F
SG
MID
PV
A
S
LEGPG
R
W
I
G
E
---VY
PT
S
HF
LT
IA
R
G
T
FS
K
A
L
D
L
T
DL
W
QL
F
I
PLL
I
fig|511693.5.peg.3509
Escherichia coli BL21 (540-893/911)
LR
RLFS
Y
SR
R
E
A
L
E
L
R
RDP
VRSTLALMGT
V
I
L
M
L
I
M
G
Y
GI
S
M
---------
D
V
E
N
L
R
F
A
V
L
D
R
DQ
TVS
S
QAW
T
LN
L
S
G
SRY
F
IEQ
P
P
L
T
S
Y
DE
L
D
RR
M
R
AG
DI
T
V
AI
E
IPPNF
G
R
--
D
IAR
G
T
P
V
E
L
G
V
W
I
DG
AMP
S
R
A
E
T
VK
GY
V
Q
A
M
HQSWL
Q
DVAS
R
QST
P
A
SQS
G
L
M
NI
ETR
Y
RYNP
DVK
SL
PA
I
VP
A
VI
P
L
L
--
L
M
M
IPS
M
L
S
A
LSV
V
RE
K
E
L
G
S
I
IN
L
Y
V
T
P
T
T
RS
E
F
L
L
GK
-
---
Q
LP
Y
I
A
L
GM
L
NFF
L
L
CGLSVF
V
F
GVP
HK
GS
FL
TL
T
L
AAL
LY
IIIA
TG
M
GLLIST
FMK
SQ
I
A
A
IF
G
T
A
I
I
T
L
I
PA
TQ
F
SG
MID
PV
A
S
LEGPG
R
W
I
G
E
---VY
PT
S
HF
LT
IA
R
G
T
FS
K
A
L
D
L
T
DL
W
QL
F
I
PLL
I
fig|469008.4.peg.271
Escherichia coli BL21(DE3) (540-893/911)
LR
RLFS
Y
SR
R
E
A
L
E
L
R
RDP
VRSTLALMGT
V
I
L
M
L
I
M
G
Y
GI
S
M
---------
D
V
E
N
L
R
F
A
V
L
D
R
DQ
TVS
S
QAW
T
LN
L
S
G
SRY
F
IEQ
P
P
L
T
S
Y
DE
L
D
RR
M
R
AG
DI
T
V
AI
E
IPPNF
G
R
--
D
IAR
G
T
P
V
E
L
G
V
W
I
DG
AMP
S
R
A
E
T
VK
GY
V
Q
A
M
HQSWL
Q
DVAS
R
QST
P
A
SQS
G
L
M
NI
ETR
Y
RYNP
DVK
SL
PA
I
VP
A
VI
P
L
L
--
L
M
M
IPS
M
L
S
A
LSV
V
RE
K
E
L
G
S
I
IN
L
Y
V
T
P
T
T
RS
E
F
L
L
GK
-
---
Q
LP
Y
I
A
L
GM
L
NFF
L
L
CGLSVF
V
F
GVP
HK
GS
FL
TL
T
L
AAL
LY
IIIA
TG
M
GLLIST
FMK
SQ
I
A
A
IF
G
T
A
I
I
T
L
I
PA
TQ
F
SG
MID
PV
A
S
LEGPG
R
W
I
G
E
---VY
PT
S
HF
LT
IA
R
G
T
FS
K
A
L
D
L
T
DL
W
QL
F
I
PLL
I
fig|595496.3.peg.3468
Escherichia coli BW2952 (540-893/911)
LR
RLFS
Y
SR
R
E
A
L
E
L
R
RDP
VRSTLALMGT
V
I
L
M
L
I
M
G
Y
GI
S
M
---------
D
V
E
N
L
R
F
A
V
L
D
R
DQ
TVS
S
QAW
T
LN
L
S
G
SRY
F
IEQ
P
P
L
T
S
Y
DE
L
D
RR
M
R
AG
DI
T
V
AI
E
IPPNF
G
R
--
D
IAR
G
T
P
V
E
L
G
V
W
I
DG
AMP
S
R
A
E
T
VK
GY
V
Q
A
M
HQSWL
Q
DVAS
R
QST
P
A
SQS
G
L
M
NI
ETR
Y
RYNP
DVK
SL
PA
I
VP
A
VI
P
L
L
--
L
M
M
IPS
M
L
S
A
LSV
V
RE
K
E
L
G
S
I
IN
L
Y
V
T
P
T
T
RS
E
F
L
L
GK
-
---
Q
LP
Y
I
A
L
GM
L
NFF
L
L
CGLSVF
V
F
GVP
HK
GS
FL
TL
T
L
AAL
LY
IIIA
TG
M
GLLIST
FMK
SQ
I
A
A
IF
G
T
A
I
I
T
L
I
PA
TQ
F
SG
MID
PV
A
S
LEGPG
R
W
I
G
E
---VY
PT
S
HF
LT
IA
R
G
T
FS
K
A
L
D
L
T
DL
W
QL
F
I
PLL
I
fig|536056.3.peg.241
Escherichia coli DH1 (540-893/911)
LR
RLFS
Y
SR
R
E
A
L
E
L
R
RDP
VRSTLALMGT
V
I
L
M
L
I
M
G
Y
GI
S
M
---------
D
V
E
N
L
R
F
A
V
L
D
R
DQ
TVS
S
QAW
T
LN
L
S
G
SRY
F
IEQ
P
P
L
T
S
Y
DE
L
D
RR
M
R
AG
DI
T
V
AI
E
IPPNF
G
R
--
D
IAR
G
T
P
V
E
L
G
V
W
I
DG
AMP
S
R
A
E
T
VK
GY
V
Q
A
M
HQSWL
Q
DVAS
R
QST
P
A
SQS
G
L
M
NI
ETR
Y
RYNP
DVK
SL
PA
I
VP
A
VI
P
L
L
--
L
M
M
IPS
M
L
S
A
LSV
V
RE
K
E
L
G
S
I
IN
L
Y
V
T
P
T
T
RS
E
F
L
L
GK
-
---
Q
LP
Y
I
A
L
GM
L
NFF
L
L
CGLSVF
V
F
GVP
HK
GS
FL
TL
T
L
AAL
LY
IIIA
TG
M
GLLIST
FMK
SQ
I
A
A
IF
G
T
A
I
I
T
L
I
PA
TQ
F
SG
MID
PV
A
S
LEGPG
R
W
I
G
E
---VY
PT
S
HF
LT
IA
R
G
T
FS
K
A
L
D
L
T
DL
W
QL
F
I
PLL
I
fig|340185.3.peg.117
Escherichia coli E22 (540-893/911)
LR
RLFS
Y
SR
R
E
A
L
E
L
R
RDP
VRSTLALMGT
V
I
L
M
L
I
M
G
Y
GI
S
M
---------
D
V
E
N
L
R
F
A
V
L
D
R
DQ
TVS
S
QAW
T
LN
L
S
G
SRY
F
IEQ
P
P
L
T
S
Y
DE
L
D
RR
M
R
AG
DI
T
V
AI
E
IPPNF
G
R
--
D
IAR
G
T
P
V
E
L
G
V
W
I
DG
AMP
S
R
A
E
T
VK
GY
V
Q
A
M
HQSWL
Q
DVAS
R
QST
P
A
SQS
G
L
M
NI
ETR
Y
RYNP
DVK
SL
PA
I
VP
A
VI
P
L
L
--
L
M
M
IPS
M
L
S
A
LSV
V
RE
K
E
L
G
S
I
IN
L
Y
V
T
P
T
T
RS
E
F
L
L
GK
-
---
Q
LP
Y
I
A
L
GM
L
NFF
L
L
CGLSVF
V
F
GVP
HK
GS
FL
TL
T
L
AAL
LY
IIIA
TG
M
GLLIST
FMK
SQ
I
A
A
IF
G
T
A
I
I
T
L
I
PA
TQ
F
SG
MID
PV
A
S
LEGPG
R
W
I
G
E
---VY
PT
S
HF
LT
IA
R
G
T
FS
K
A
L
D
L
T
DL
W
QL
F
I
PLL
I
fig|340185.4.peg.131
Escherichia coli E22 (540-893/911)
LR
RLFS
Y
SR
R
E
A
L
E
L
R
RDP
VRSTLALMGT
V
I
L
M
L
I
M
G
Y
GI
S
M
---------
D
V
E
N
L
R
F
A
V
L
D
R
DQ
TVS
S
QAW
T
LN
L
S
G
SRY
F
IEQ
P
P
L
T
S
Y
DE
L
D
RR
M
R
AG
DI
T
V
AI
E
IPPNF
G
R
--
D
IAR
G
T
P
V
E
L
G
V
W
I
DG
AMP
S
R
A
E
T
VK
GY
V
Q
A
M
HQSWL
Q
DVAS
R
QST
P
A
SQS
G
L
M
NI
ETR
Y
RYNP
DVK
SL
PA
I
VP
A
VI
P
L
L
--
L
M
M
IPS
M
L
S
A
LSV
V
RE
K
E
L
G
S
I
IN
L
Y
V
T
P
T
T
RS
E
F
L
L
GK
-
---
Q
LP
Y
I
A
L
GM
L
NFF
L
L
CGLSVF
V
F
GVP
HK
GS
FL
TL
T
L
AAL
LY
IIIA
TG
M
GLLIST
FMK
SQ
I
A
A
IF
G
T
A
I
I
T
L
I
PA
TQ
F
SG
MID
PV
A
S
LEGPG
R
W
I
G
E
---VY
PT
S
HF
LT
IA
R
G
T
FS
K
A
L
D
L
T
DL
W
QL
F
I
PLL
I
fig|331111.12.peg.4206
Escherichia coli E24377A (540-893/911)
LR
RLFS
Y
SR
R
E
A
L
E
L
R
RDP
VRSTLALMGT
V
I
L
M
L
I
M
G
Y
GI
S
M
---------
D
V
E
N
L
R
F
A
V
L
D
R
DQ
TVS
S
QAW
T
LN
L
S
G
SRY
F
IEQ
P
P
L
T
S
Y
DE
L
D
RR
M
R
AG
DI
T
V
AI
E
IPPNF
G
R
--
D
IAR
G
T
P
V
E
L
G
V
W
I
DG
AMP
S
R
A
E
T
VK
GY
V
Q
A
M
HQSWL
Q
DVAS
R
QST
P
A
SQS
G
L
M
NI
ETR
Y
RYNP
DVK
SL
PA
I
VP
A
VI
P
L
L
--
L
M
M
IPS
M
L
S
A
LSV
V
RE
K
E
L
G
S
I
IN
L
Y
V
T
P
T
T
RS
E
F
L
L
GK
-
---
Q
LP
Y
I
A
L
GM
L
NFF
L
L
CGLSVF
V
F
GVP
HK
GS
FL
TL
T
L
AAL
LY
IIIA
TG
M
GLLIST
FMK
SQ
I
A
A
IF
G
T
A
I
I
T
L
I
PA
TQ
F
SG
MID
PV
A
S
LEGPG
R
W
I
G
E
---VY
PT
S
HF
LT
IA
R
G
T
FS
K
A
L
D
L
T
DL
W
QL
F
I
PLL
I
fig|331111.3.peg.1621
Escherichia coli E24377A (540-893/911)
LR
RLFS
Y
SR
R
E
A
L
E
L
R
RDP
VRSTLALMGT
V
I
L
M
L
I
M
G
Y
GI
S
M
---------
D
V
E
N
L
R
F
A
V
L
D
R
DQ
TVS
S
QAW
T
LN
L
S
G
SRY
F
IEQ
P
P
L
T
S
Y
DE
L
D
RR
M
R
AG
DI
T
V
AI
E
IPPNF
G
R
--
D
IAR
G
T
P
V
E
L
G
V
W
I
DG
AMP
S
R
A
E
T
VK
GY
V
Q
A
M
HQSWL
Q
DVAS
R
QST
P
A
SQS
G
L
M
NI
ETR
Y
RYNP
DVK
SL
PA
I
VP
A
VI
P
L
L
--
L
M
M
IPS
M
L
S
A
LSV
V
RE
K
E
L
G
S
I
IN
L
Y
V
T
P
T
T
RS
E
F
L
L
GK
-
---
Q
LP
Y
I
A
L
GM
L
NFF
L
L
CGLSVF
V
F
GVP
HK
GS
FL
TL
T
L
AAL
LY
IIIA
TG
M
GLLIST
FMK
SQ
I
A
A
IF
G
T
A
I
I
T
L
I
PA
TQ
F
SG
MID
PV
A
S
LEGPG
R
W
I
G
E
---VY
PT
S
HF
LT
IA
R
G
T
FS
K
A
L
D
L
T
DL
W
QL
F
I
PLL
I
fig|562.375.peg.4838
Escherichia coli EC4100B (540-893/911)
LR
RLFS
Y
SR
R
E
A
L
E
L
R
RDP
VRSTLALMGT
V
I
L
M
L
I
M
G
Y
GI
S
M
---------
D
V
E
N
L
R
F
A
V
L
D
R
DQ
TVS
S
QAW
T
LN
L
S
G
SRY
F
IEQ
P
P
L
T
S
Y
DE
L
D
RR
M
R
AG
DI
T
V
AI
E
IPPNF
G
R
--
D
IAR
G
T
P
V
E
L
G
V
W
I
DG
AMP
S
R
A
E
T
VK
GY
V
Q
A
M
HQSWL
Q
DVAS
R
QST
P
A
SQS
G
L
M
NI
ETR
Y
RYNP
DVK
SL
PA
I
VP
A
VI
P
L
L
--
L
M
M
IPS
M
L
S
A
LSV
V
RE
K
E
L
G
S
I
IN
L
Y
V
T
P
T
T
RS
E
F
L
L
GK
-
---
Q
LP
Y
I
A
L
GM
L
NFF
L
L
CGLSVF
V
F
GVP
HK
GS
FL
TL
T
L
AAL
LY
IIIA
TG
M
GLLIST
FMK
SQ
I
A
A
IF
G
T
A
I
I
T
L
I
PA
TQ
F
SG
MID
PV
A
S
LEGPG
R
W
I
G
E
---VY
PT
S
HF
LT
IA
R
G
T
FS
K
A
L
D
L
T
DL
W
QL
F
I
PLL
I
fig|656393.3.peg.4544
Escherichia coli H299 (540-893/911)
LR
RLFS
Y
SR
R
E
A
L
E
L
R
RDP
VRSTLALMGT
V
I
L
M
L
I
M
G
Y
GI
S
M
---------
D
V
E
N
L
R
F
A
V
L
D
R
DQ
TVS
S
QAW
T
LN
L
S
G
SRY
F
IEQ
P
P
L
T
S
Y
DE
L
D
RR
M
R
AG
DI
T
V
AI
E
IPPNF
G
R
--
D
IAR
G
T
P
V
E
L
G
V
W
I
DG
AMP
S
R
A
E
T
VK
GY
V
Q
A
M
HQSWL
Q
DVAS
R
QST
P
A
SQS
G
L
M
NI
ETR
Y
RYNP
DVK
SL
PA
I
VP
A
VI
P
L
L
--
L
M
M
IPS
M
L
S
A
LSV
V
RE
K
E
L
G
S
I
IN
L
Y
V
T
P
T
T
RS
E
F
L
L
GK
-
---
Q
LP
Y
I
A
L
GM
L
NFF
L
L
CGLSVF
V
F
GVP
HK
GS
FL
TL
T
L
AAL
LY
IIIA
TG
M
GLLIST
FMK
SQ
I
A
A
IF
G
T
A
I
I
T
L
I
PA
TQ
F
SG
MID
PV
A
S
LEGPG
R
W
I
G
E
---VY
PT
S
HF
LT
IA
R
G
T
FS
K
A
L
D
L
T
DL
W
QL
F
I
PLL
I
fig|656408.3.peg.3908
Escherichia coli H591 (540-893/911)
LR
RLFS
Y
SR
R
E
A
L
E
L
R
RDP
VRSTLALMGT
V
I
L
M
L
I
M
G
Y
GI
S
M
---------
D
V
E
N
L
R
F
A
V
L
D
R
DQ
TVS
S
QAW
T
LN
L
S
G
SRY
F
IEQ
P
P
L
T
S
Y
DE
L
D
RR
M
R
AG
DI
T
V
AI
E
IPPNF
G
R
--
D
IAR
G
T
P
V
E
L
G
V
W
I
DG
AMP
S
R
A
E
T
VK
GY
V
Q
A
M
HQSWL
Q
DVAS
R
QST
P
A
SQS
G
L
M
NI
ETR
Y
RYNP
DVK
SL
PA
I
VP
A
VI
P
L
L
--
L
M
M
IPS
M
L
S
A
LSV
V
RE
K
E
L
G
S
I
IN
L
Y
V
T
P
T
T
RS
E
F
L
L
GK
-
---
Q
LP
Y
I
A
L
GM
L
NFF
L
L
CGLSVF
V
F
GVP
HK
GS
FL
TL
T
L
AAL
LY
IIIA
TG
M
GLLIST
FMK
SQ
I
A
A
IF
G
T
A
I
I
T
L
I
PA
TQ
F
SG
MID
PV
A
S
LEGPG
R
W
I
G
E
---VY
PT
S
HF
LT
IA
R
G
T
FS
K
A
L
D
L
T
DL
W
QL
F
I
PLL
I
fig|656414.3.peg.3975
Escherichia coli H736 (540-893/911)
LR
RLFS
Y
SR
R
E
A
L
E
L
R
RDP
VRSTLALMGT
V
I
L
M
L
I
M
G
Y
GI
S
M
---------
D
V
E
N
L
R
F
A
V
L
D
R
DQ
TVS
S
QAW
T
LN
L
S
G
SRY
F
IEQ
P
P
L
T
S
Y
DE
L
D
RR
M
R
AG
DI
T
V
AI
E
IPPNF
G
R
--
D
IAR
G
T
P
V
E
L
G
V
W
I
DG
AMP
S
R
A
E
T
VK
GY
V
Q
A
M
HQSWL
Q
DVAS
R
QST
P
A
SQS
G
L
M
NI
ETR
Y
RYNP
DVK
SL
PA
I
VP
A
VI
P
L
L
--
L
M
M
IPS
M
L
S
A
LSV
V
RE
K
E
L
G
S
I
IN
L
Y
V
T
P
T
T
RS
E
F
L
L
GK
-
---
Q
LP
Y
I
A
L
GM
L
NFF
L
L
CGLSVF
V
F
GVP
HK
GS
FL
TL
T
L
AAL
LY
IIIA
TG
M
GLLIST
FMK
SQ
I
A
A
IF
G
T
A
I
I
T
L
I
PA
TQ
F
SG
MID
PV
A
S
LEGPG
R
W
I
G
E
---VY
PT
S
HF
LT
IA
R
G
T
FS
K
A
L
D
L
T
DL
W
QL
F
I
PLL
I
fig|585034.4.peg.3551
Escherichia coli IAI1 (540-893/911)
LR
RLFS
Y
SR
R
E
A
L
E
L
R
RDP
VRSTLALMGT
V
I
L
M
L
I
M
G
Y
GI
S
M
---------
D
V
E
N
L
R
F
A
V
L
D
R
DQ
TVS
S
QAW
T
LN
L
S
G
SRY
F
IEQ
P
P
L
T
S
Y
DE
L
D
RR
M
R
AG
DI
T
V
AI
E
IPPNF
G
R
--
D
IAR
G
T
P
V
E
L
G
V
W
I
DG
AMP
S
R
A
E
T
VK
GY
V
Q
A
M
HQSWL
Q
DVAS
R
QST
P
A
SQS
G
L
M
NI
ETR
Y
RYNP
DVK
SL
PA
I
VP
A
VI
P
L
L
--
L
M
M
IPS
M
L
S
A
LSV
V
RE
K
E
L
G
S
I
IN
L
Y
V
T
P
T
T
RS
E
F
L
L
GK
-
---
Q
LP
Y
I
A
L
GM
L
NFF
L
L
CGLSVF
V
F
GVP
HK
GS
FL
TL
T
L
AAL
LY
IIIA
TG
M
GLLIST
FMK
SQ
I
A
A
IF
G
T
A
I
I
T
L
I
PA
TQ
F
SG
MID
PV
A
S
LEGPG
R
W
I
G
E
---VY
PT
S
HF
LT
IA
R
G
T
FS
K
A
L
D
L
T
DL
W
QL
F
I
PLL
I
fig|585034.5.peg.3549
Escherichia coli IAI1 (540-893/911)
LR
RLFS
Y
SR
R
E
A
L
E
L
R
RDP
VRSTLALMGT
V
I
L
M
L
I
M
G
Y
GI
S
M
---------
D
V
E
N
L
R
F
A
V
L
D
R
DQ
TVS
S
QAW
T
LN
L
S
G
SRY
F
IEQ
P
P
L
T
S
Y
DE
L
D
RR
M
R
AG
DI
T
V
AI
E
IPPNF
G
R
--
D
IAR
G
T
P
V
E
L
G
V
W
I
DG
AMP
S
R
A
E
T
VK
GY
V
Q
A
M
HQSWL
Q
DVAS
R
QST
P
A
SQS
G
L
M
NI
ETR
Y
RYNP
DVK
SL
PA
I
VP
A
VI
P
L
L
--
L
M
M
IPS
M
L
S
A
LSV
V
RE
K
E
L
G
S
I
IN
L
Y
V
T
P
T
T
RS
E
F
L
L
GK
-
---
Q
LP
Y
I
A
L
GM
L
NFF
L
L
CGLSVF
V
F
GVP
HK
GS
FL
TL
T
L
AAL
LY
IIIA
TG
M
GLLIST
FMK
SQ
I
A
A
IF
G
T
A
I
I
T
L
I
PA
TQ
F
SG
MID
PV
A
S
LEGPG
R
W
I
G
E
---VY
PT
S
HF
LT
IA
R
G
T
FS
K
A
L
D
L
T
DL
W
QL
F
I
PLL
I
fig|595495.4.peg.1422
Escherichia coli KO11 (540-893/911)
LR
RLFS
Y
SR
R
E
A
L
E
L
R
RDP
VRSTLALMGT
V
I
L
M
L
I
M
G
Y
GI
S
M
---------
D
V
E
N
L
R
F
A
V
L
D
R
DQ
TVS
S
QAW
T
LN
L
S
G
SRY
F
IEQ
P
P
L
T
S
Y
DE
L
D
RR
M
R
AG
DI
T
V
AI
E
IPPNF
G
R
--
D
IAR
G
T
P
V
E
L
G
V
W
I
DG
AMP
S
R
A
E
T
VK
GY
V
Q
A
M
HQSWL
Q
DVAS
R
QST
P
A
SQS
G
L
M
NI
ETR
Y
RYNP
DVK
SL
PA
I
VP
A
VI
P
L
L
--
L
M
M
IPS
M
L
S
A
LSV
V
RE
K
E
L
G
S
I
IN
L
Y
V
T
P
T
T
RS
E
F
L
L
GK
-
---
Q
LP
Y
I
A
L
GM
L
NFF
L
L
CGLSVF
V
F
GVP
HK
GS
FL
TL
T
L
AAL
LY
IIIA
TG
M
GLLIST
FMK
SQ
I
A
A
IF
G
T
A
I
I
T
L
I
PA
TQ
F
SG
MID
PV
A
S
LEGPG
R
W
I
G
E
---VY
PT
S
HF
LT
IA
R
G
T
FS
K
A
L
D
L
T
DL
W
QL
F
I
PLL
I
fig|749538.3.peg.4011
Escherichia coli MS 116-1 (540-893/911)
LR
RLFS
Y
SR
R
E
A
L
E
L
R
RDP
VRSTLALMGT
V
I
L
M
L
I
M
G
Y
GI
S
M
---------
D
V
E
N
L
R
F
A
V
L
D
R
DQ
TVS
S
QAW
T
LN
L
S
G
SRY
F
IEQ
P
P
L
T
S
Y
DE
L
D
RR
M
R
AG
DI
T
V
AI
E
IPPNF
G
R
--
D
IAR
G
T
P
V
E
L
G
V
W
I
DG
AMP
S
R
A
E
T
VK
GY
V
Q
A
M
HQSWL
Q
DVAS
R
QST
P
A
SQS
G
L
M
NI
ETR
Y
RYNP
DVK
SL
PA
I
VP
A
VI
P
L
L
--
L
M
M
IPS
M
L
S
A
LSV
V
RE
K
E
L
G
S
I
IN
L
Y
V
T
P
T
T
RS
E
F
L
L
GK
-
---
Q
LP
Y
I
A
L
GM
L
NFF
L
L
CGLSVF
V
F
GVP
HK
GS
FL
TL
T
L
AAL
LY
IIIA
TG
M
GLLIST
FMK
SQ
I
A
A
IF
G
T
A
I
I
T
L
I
PA
TQ
F
SG
MID
PV
A
S
LEGPG
R
W
I
G
E
---VY
PT
S
HF
LT
IA
R
G
T
FS
K
A
L
D
L
T
DL
W
QL
F
I
PLL
I
fig|679206.4.peg.2483
Escherichia coli MS 119-7 (540-893/911)
LR
RLFS
Y
SR
R
E
A
L
E
L
R
RDP
VRSTLALMGT
V
I
L
M
L
I
M
G
Y
GI
S
M
---------
D
V
E
N
L
R
F
A
V
L
D
R
DQ
TVS
S
QAW
T
LN
L
S
G
SRY
F
IEQ
P
P
L
T
S
Y
DE
L
D
RR
M
R
AG
DI
T
V
AI
E
IPPNF
G
R
--
D
IAR
G
T
P
V
E
L
G
V
W
I
DG
AMP
S
R
A
E
T
VK
GY
V
Q
A
M
HQSWL
Q
DVAS
R
QST
P
A
SQS
G
L
M
NI
ETR
Y
RYNP
DVK
SL
PA
I
VP
A
VI
P
L
L
--
L
M
M
IPS
M
L
S
A
LSV
V
RE
K
E
L
G
S
I
IN
L
Y
V
T
P
T
T
RS
E
F
L
L
GK
-
---
Q
LP
Y
I
A
L
GM
L
NFF
L
L
CGLSVF
V
F
GVP
HK
GS
FL
TL
T
L
AAL
LY
IIIA
TG
M
GLLIST
FMK
SQ
I
A
A
IF
G
T
A
I
I
T
L
I
PA
TQ
F
SG
MID
PV
A
S
LEGPG
R
W
I
G
E
---VY
PT
S
HF
LT
IA
R
G
T
FS
K
A
L
D
L
T
DL
W
QL
F
I
PLL
I
fig|749540.3.peg.1967
Escherichia coli MS 146-1 (540-893/911)
LR
RLFS
Y
SR
R
E
A
L
E
L
R
RDP
VRSTLALMGT
V
I
L
M
L
I
M
G
Y
GI
S
M
---------
D
V
E
N
L
R
F
A
V
L
D
R
DQ
TVS
S
QAW
T
LN
L
S
G
SRY
F
IEQ
P
P
L
T
S
Y
DE
L
D
RR
M
R
AG
DI
T
V
AI
E
IPPNF
G
R
--
D
IAR
G
T
P
V
E
L
G
V
W
I
DG
AMP
S
R
A
E
T
VK
GY
V
Q
A
M
HQSWL
Q
DVAS
R
QST
P
A
SQS
G
L
M
NI
ETR
Y
RYNP
DVK
SL
PA
I
VP
A
VI
P
L
L
--
L
M
M
IPS
M
L
S
A
LSV
V
RE
K
E
L
G
S
I
IN
L
Y
V
T
P
T
T
RS
E
F
L
L
GK
-
---
Q
LP
Y
I
A
L
GM
L
NFF
L
L
CGLSVF
V
F
GVP
HK
GS
FL
TL
T
L
AAL
LY
IIIA
TG
M
GLLIST
FMK
SQ
I
A
A
IF
G
T
A
I
I
T
L
I
PA
TQ
F
SG
MID
PV
A
S
LEGPG
R
W
I
G
E
---VY
PT
S
HF
LT
IA
R
G
T
FS
K
A
L
D
L
T
DL
W
QL
F
I
PLL
I
fig|749544.3.peg.3012
Escherichia coli MS 175-1 (540-893/911)
LR
RLFS
Y
SR
R
E
A
L
E
L
R
RDP
VRSTLALMGT
V
I
L
M
L
I
M
G
Y
GI
S
M
---------
D
V
E
N
L
R
F
A
V
L
D
R
DQ
TVS
S
QAW
T
LN
L
S
G
SRY
F
IEQ
P
P
L
T
S
Y
DE
L
D
RR
M
R
AG
DI
T
V
AI
E
IPPNF
G
R
--
D
IAR
G
T
P
V
E
L
G
V
W
I
DG
AMP
S
R
A
E
T
VK
GY
V
Q
A
M
HQSWL
Q
DVAS
R
QST
P
A
SQS
G
L
M
NI
ETR
Y
RYNP
DVK
SL
PA
I
VP
A
VI
P
L
L
--
L
M
M
IPS
M
L
S
A
LSV
V
RE
K
E
L
G
S
I
IN
L
Y
V
T
P
T
T
RS
E
F
L
L
GK
-
---
Q
LP
Y
I
A
L
GM
L
NFF
L
L
CGLSVF
V
F
GVP
HK
GS
FL
TL
T
L
AAL
LY
IIIA
TG
M
GLLIST
FMK
SQ
I
A
A
IF
G
T
A
I
I
T
L
I
PA
TQ
F
SG
MID
PV
A
S
LEGPG
R
W
I
G
E
---VY
PT
S
HF
LT
IA
R
G
T
FS
K
A
L
D
L
T
DL
W
QL
F
I
PLL
I
fig|749545.3.peg.4612
Escherichia coli MS 182-1 (540-893/911)
LR
RLFS
Y
SR
R
E
A
L
E
L
R
RDP
VRSTLALMGT
V
I
L
M
L
I
M
G
Y
GI
S
M
---------
D
V
E
N
L
R
F
A
V
L
D
R
DQ
TVS
S
QAW
T
LN
L
S
G
SRY
F
IEQ
P
P
L
T
S
Y
DE
L
D
RR
M
R
AG
DI
T
V
AI
E
IPPNF
G
R
--
D
IAR
G
T
P
V
E
L
G
V
W
I
DG
AMP
S
R
A
E
T
VK
GY
V
Q
A
M
HQSWL
Q
DVAS
R
QST
P
A
SQS
G
L
M
NI
ETR
Y
RYNP
DVK
SL
PA
I
VP
A
VI
P
L
L
--
L
M
M
IPS
M
L
S
A
LSV
V
RE
K
E
L
G
S
I
IN
L
Y
V
T
P
T
T
RS
E
F
L
L
GK
-
---
Q
LP
Y
I
A
L
GM
L
NFF
L
L
CGLSVF
V
F
GVP
HK
GS
FL
TL
T
L
AAL
LY
IIIA
TG
M
GLLIST
FMK
SQ
I
A
A
IF
G
T
A
I
I
T
L
I
PA
TQ
F
SG
MID
PV
A
S
LEGPG
R
W
I
G
E
---VY
PT
S
HF
LT
IA
R
G
T
FS
K
A
L
D
L
T
DL
W
QL
F
I
PLL
I
fig|749548.3.peg.120
Escherichia coli MS 196-1 (540-893/911)
LR
RLFS
Y
SR
R
E
A
L
E
L
R
RDP
VRSTLALMGT
V
I
L
M
L
I
M
G
Y
GI
S
M
---------
D
V
E
N
L
R
F
A
V
L
D
R
DQ
TVS
S
QAW
T
LN
L
S
G
SRY
F
IEQ
P
P
L
T
S
Y
DE
L
D
RR
M
R
AG
DI
T
V
AI
E
IPPNF
G
R
--
D
IAR
G
T
P
V
E
L
G
V
W
I
DG
AMP
S
R
A
E
T
VK
GY
V
Q
A
M
HQSWL
Q
DVAS
R
QST
P
A
SQS
G
L
M
NI
ETR
Y
RYNP
DVK
SL
PA
I
VP
A
VI
P
L
L
--
L
M
M
IPS
M
L
S
A
LSV
V
RE
K
E
L
G
S
I
IN
L
Y
V
T
P
T
T
RS
E
F
L
L
GK
-
---
Q
LP
Y
I
A
L
GM
L
NFF
L
L
CGLSVF
V
F
GVP
HK
GS
FL
TL
T
L
AAL
LY
IIIA
TG
M
GLLIST
FMK
SQ
I
A
A
IF
G
T
A
I
I
T
L
I
PA
TQ
F
SG
MID
PV
A
S
LEGPG
R
W
I
G
E
---VY
PT
S
HF
LT
IA
R
G
T
FS
K
A
L
D
L
T
DL
W
QL
F
I
PLL
I
fig|749532.3.peg.4047
Escherichia coli MS 78-1 (540-893/911)
LR
RLFS
Y
SR
R
E
A
L
E
L
R
RDP
VRSTLALMGT
V
I
L
M
L
I
M
G
Y
GI
S
M
---------
D
V
E
N
L
R
F
A
V
L
D
R
DQ
TVS
S
QAW
T
LN
L
S
G
SRY
F
IEQ
P
P
L
T
S
Y
DE
L
D
RR
M
R
AG
DI
T
V
AI
E
IPPNF
G
R
--
D
IAR
G
T
P
V
E
L
G
V
W
I
DG
AMP
S
R
A
E
T
VK
GY
V
Q
A
M
HQSWL
Q
DVAS
R
QST
P
A
SQS
G
L
M
NI
ETR
Y
RYNP
DVK
SL
PA
I
VP
A
VI
P
L
L
--
L
M
M
IPS
M
L
S
A
LSV
V
RE
K
E
L
G
S
I
IN
L
Y
V
T
P
T
T
RS
E
F
L
L
GK
-
---
Q
LP
Y
I
A
L
GM
L
NFF
L
L
CGLSVF
V
F
GVP
HK
GS
FL
TL
T
L
AAL
LY
IIIA
TG
M
GLLIST
FMK
SQ
I
A
A
IF
G
T
A
I
I
T
L
I
PA
TQ
F
SG
MID
PV
A
S
LEGPG
R
W
I
G
E
---VY
PT
S
HF
LT
IA
R
G
T
FS
K
A
L
D
L
T
DL
W
QL
F
I
PLL
I
fig|585395.4.peg.4400
Escherichia coli O103:H2 str. 12009 (540-893/911)
LR
RLFS
Y
SR
R
E
A
L
E
L
R
RDP
VRSTLALMGT
V
I
L
M
L
I
M
G
Y
GI
S
M
---------
D
V
E
N
L
R
F
A
V
L
D
R
DQ
TVS
S
QAW
T
LN
L
S
G
SRY
F
IEQ
P
P
L
T
S
Y
DE
L
D
RR
M
R
AG
DI
T
V
AI
E
IPPNF
G
R
--
D
IAR
G
T
P
V
E
L
G
V
W
I
DG
AMP
S
R
A
E
T
VK
GY
V
Q
A
M
HQSWL
Q
DVAS
R
QST
P
A
SQS
G
L
M
NI
ETR
Y
RYNP
DVK
SL
PA
I
VP
A
VI
P
L
L
--
L
M
M
IPS
M
L
S
A
LSV
V
RE
K
E
L
G
S
I
IN
L
Y
V
T
P
T
T
RS
E
F
L
L
GK
-
---
Q
LP
Y
I
A
L
GM
L
NFF
L
L
CGLSVF
V
F
GVP
HK
GS
FL
TL
T
L
AAL
LY
IIIA
TG
M
GLLIST
FMK
SQ
I
A
A
IF
G
T
A
I
I
T
L
I
PA
TQ
F
SG
MID
PV
A
S
LEGPG
R
W
I
G
E
---VY
PT
S
HF
LT
IA
R
G
T
FS
K
A
L
D
L
T
DL
W
QL
F
I
PLL
I
fig|573235.3.peg.4686
Escherichia coli O26:H11 str. 11368 (540-893/911)
LR
RLFS
Y
SR
R
E
A
L
E
L
R
RDP
VRSTLALMGT
V
I
L
M
L
I
M
G
Y
GI
S
M
---------
D
V
E
N
L
R
F
A
V
L
D
R
DQ
TVS
S
QAW
T
LN
L
S
G
SRY
F
IEQ
P
P
L
T
S
Y
DE
L
D
RR
M
R
AG
DI
T
V
AI
E
IPPNF
G
R
--
D
IAR
G
T
P
V
E
L
G
V
W
I
DG
AMP
S
R
A
E
T
VK
GY
V
Q
A
M
HQSWL
Q
DVAS
R
QST
P
A
SQS
G
L
M
NI
ETR
Y
RYNP
DVK
SL
PA
I
VP
A
VI
P
L
L
--
L
M
M
IPS
M
L
S
A
LSV
V
RE
K
E
L
G
S
I
IN
L
Y
V
T
P
T
T
RS
E
F
L
L
GK
-
---
Q
LP
Y
I
A
L
GM
L
NFF
L
L
CGLSVF
V
F
GVP
HK
GS
FL
TL
T
L
AAL
LY
IIIA
TG
M
GLLIST
FMK
SQ
I
A
A
IF
G
T
A
I
I
T
L
I
PA
TQ
F
SG
MID
PV
A
S
LEGPG
R
W
I
G
E
---VY
PT
S
HF
LT
IA
R
G
T
FS
K
A
L
D
L
T
DL
W
QL
F
I
PLL
I
fig|409438.11.peg.3921
Escherichia coli SE11 (540-893/911)
LR
RLFS
Y
SR
R
E
A
L
E
L
R
RDP
VRSTLALMGT
V
I
L
M
L
I
M
G
Y
GI
S
M
---------
D
V
E
N
L
R
F
A
V
L
D
R
DQ
TVS
S
QAW
T
LN
L
S
G
SRY
F
IEQ
P
P
L
T
S
Y
DE
L
D
RR
M
R
AG
DI
T
V
AI
E
IPPNF
G
R
--
D
IAR
G
T
P
V
E
L
G
V
W
I
DG
AMP
S
R
A
E
T
VK
GY
V
Q
A
M
HQSWL
Q
DVAS
R
QST
P
A
SQS
G
L
M
NI
ETR
Y
RYNP
DVK
SL
PA
I
VP
A
VI
P
L
L
--
L
M
M
IPS
M
L
S
A
LSV
V
RE
K
E
L
G
S
I
IN
L
Y
V
T
P
T
T
RS
E
F
L
L
GK
-
---
Q
LP
Y
I
A
L
GM
L
NFF
L
L
CGLSVF
V
F
GVP
HK
GS
FL
TL
T
L
AAL
LY
IIIA
TG
M
GLLIST
FMK
SQ
I
A
A
IF
G
T
A
I
I
T
L
I
PA
TQ
F
SG
MID
PV
A
S
LEGPG
R
W
I
G
E
---VY
PT
S
HF
LT
IA
R
G
T
FS
K
A
L
D
L
T
DL
W
QL
F
I
PLL
I
fig|656443.3.peg.4386
Escherichia coli TA271 (540-893/911)
LR
RLFS
Y
SR
R
E
A
L
E
L
R
RDP
VRSTLALMGT
V
I
L
M
L
I
M
G
Y
GI
S
M
---------
D
V
E
N
L
R
F
A
V
L
D
R
DQ
TVS
S
QAW
T
LN
L
S
G
SRY
F
IEQ
P
P
L
T
S
Y
DE
L
D
RR
M
R
AG
DI
T
V
AI
E
IPPNF
G
R
--
D
IAR
G
T
P
V
E
L
G
V
W
I
DG
AMP
S
R
A
E
T
VK
GY
V
Q
A
M
HQSWL
Q
DVAS
R
QST
P
A
SQS
G
L
M
NI
ETR
Y
RYNP
DVK
SL
PA
I
VP
A
VI
P
L
L
--
L
M
M
IPS
M
L
S
A
LSV
V
RE
K
E
L
G
S
I
IN
L
Y
V
T
P
T
T
RS
E
F
L
L
GK
-
---
Q
LP
Y
I
A
L
GM
L
NFF
L
L
CGLSVF
V
F
GVP
HK
GS
FL
TL
T
L
AAL
LY
IIIA
TG
M
GLLIST
FMK
SQ
I
A
A
IF
G
T
A
I
I
T
L
I
PA
TQ
F
SG
MID
PV
A
S
LEGPG
R
W
I
G
E
---VY
PT
S
HF
LT
IA
R
G
T
FS
K
A
L
D
L
T
DL
W
QL
F
I
PLL
I
fig|566546.3.peg.1985
Escherichia coli W (540-893/911)
LR
RLFS
Y
SR
R
E
A
L
E
L
R
RDP
VRSTLALMGT
V
I
L
M
L
I
M
G
Y
GI
S
M
---------
D
V
E
N
L
R
F
A
V
L
D
R
DQ
TVS
S
QAW
T
LN
L
S
G
SRY
F
IEQ
P
P
L
T
S
Y
DE
L
D
RR
M
R
AG
DI
T
V
AI
E
IPPNF
G
R
--
D
IAR
G
T
P
V
E
L
G
V
W
I
DG
AMP
S
R
A
E
T
VK
GY
V
Q
A
M
HQSWL
Q
DVAS
R
QST
P
A
SQS
G
L
M
NI
ETR
Y
RYNP
DVK
SL
PA
I
VP
A
VI
P
L
L
--
L
M
M
IPS
M
L
S
A
LSV
V
RE
K
E
L
G
S
I
IN
L
Y
V
T
P
T
T
RS
E
F
L
L
GK
-
---
Q
LP
Y
I
A
L
GM
L
NFF
L
L
CGLSVF
V
F
GVP
HK
GS
FL
TL
T
L
AAL
LY
IIIA
TG
M
GLLIST
FMK
SQ
I
A
A
IF
G
T
A
I
I
T
L
I
PA
TQ
F
SG
MID
PV
A
S
LEGPG
R
W
I
G
E
---VY
PT
S
HF
LT
IA
R
G
T
FS
K
A
L
D
L
T
DL
W
QL
F
I
PLL
I
fig|566546.4.peg.3701
Escherichia coli W (540-893/911)
LR
RLFS
Y
SR
R
E
A
L
E
L
R
RDP
VRSTLALMGT
V
I
L
M
L
I
M
G
Y
GI
S
M
---------
D
V
E
N
L
R
F
A
V
L
D
R
DQ
TVS
S
QAW
T
LN
L
S
G
SRY
F
IEQ
P
P
L
T
S
Y
DE
L
D
RR
M
R
AG
DI
T
V
AI
E
IPPNF
G
R
--
D
IAR
G
T
P
V
E
L
G
V
W
I
DG
AMP
S
R
A
E
T
VK
GY
V
Q
A
M
HQSWL
Q
DVAS
R
QST
P
A
SQS
G
L
M
NI
ETR
Y
RYNP
DVK
SL
PA
I
VP
A
VI
P
L
L
--
L
M
M
IPS
M
L
S
A
LSV
V
RE
K
E
L
G
S
I
IN
L
Y
V
T
P
T
T
RS
E
F
L
L
GK
-
---
Q
LP
Y
I
A
L
GM
L
NFF
L
L
CGLSVF
V
F
GVP
HK
GS
FL
TL
T
L
AAL
LY
IIIA
TG
M
GLLIST
FMK
SQ
I
A
A
IF
G
T
A
I
I
T
L
I
PA
TQ
F
SG
MID
PV
A
S
LEGPG
R
W
I
G
E
---VY
PT
S
HF
LT
IA
R
G
T
FS
K
A
L
D
L
T
DL
W
QL
F
I
PLL
I
fig|316407.3.peg.3642
Escherichia coli W3110 (540-893/911)
LR
RLFS
Y
SR
R
E
A
L
E
L
R
RDP
VRSTLALMGT
V
I
L
M
L
I
M
G
Y
GI
S
M
---------
D
V
E
N
L
R
F
A
V
L
D
R
DQ
TVS
S
QAW
T
LN
L
S
G
SRY
F
IEQ
P
P
L
T
S
Y
DE
L
D
RR
M
R
AG
DI
T
V
AI
E
IPPNF
G
R
--
D
IAR
G
T
P
V
E
L
G
V
W
I
DG
AMP
S
R
A
E
T
VK
GY
V
Q
A
M
HQSWL
Q
DVAS
R
QST
P
A
SQS
G
L
M
NI
ETR
Y
RYNP
DVK
SL
PA
I
VP
A
VI
P
L
L
--
L
M
M
IPS
M
L
S
A
LSV
V
RE
K
E
L
G
S
I
IN
L
Y
V
T
P
T
T
RS
E
F
L
L
GK
-
---
Q
LP
Y
I
A
L
GM
L
NFF
L
L
CGLSVF
V
F
GVP
HK
GS
FL
TL
T
L
AAL
LY
IIIA
TG
M
GLLIST
FMK
SQ
I
A
A
IF
G
T
A
I
I
T
L
I
PA
TQ
F
SG
MID
PV
A
S
LEGPG
R
W
I
G
E
---VY
PT
S
HF
LT
IA
R
G
T
FS
K
A
L
D
L
T
DL
W
QL
F
I
PLL
I
fig|316385.5.peg.3607
Escherichia coli str. K-12 substr. DH10B (540-893/911)
LR
RLFS
Y
SR
R
E
A
L
E
L
R
RDP
VRSTLALMGT
V
I
L
M
L
I
M
G
Y
GI
S
M
---------
D
V
E
N
L
R
F
A
V
L
D
R
DQ
TVS
S
QAW
T
LN
L
S
G
SRY
F
IEQ
P
P
L
T
S
Y
DE
L
D
RR
M
R
AG
DI
T
V
AI
E
IPPNF
G
R
--
D
IAR
G
T
P
V
E
L
G
V
W
I
DG
AMP
S
R
A
E
T
VK
GY
V
Q
A
M
HQSWL
Q
DVAS
R
QST
P
A
SQS
G
L
M
NI
ETR
Y
RYNP
DVK
SL
PA
I
VP
A
VI
P
L
L
--
L
M
M
IPS
M
L
S
A
LSV
V
RE
K
E
L
G
S
I
IN
L
Y
V
T
P
T
T
RS
E
F
L
L
GK
-
---
Q
LP
Y
I
A
L
GM
L
NFF
L
L
CGLSVF
V
F
GVP
HK
GS
FL
TL
T
L
AAL
LY
IIIA
TG
M
GLLIST
FMK
SQ
I
A
A
IF
G
T
A
I
I
T
L
I
PA
TQ
F
SG
MID
PV
A
S
LEGPG
R
W
I
G
E
---VY
PT
S
HF
LT
IA
R
G
T
FS
K
A
L
D
L
T
DL
W
QL
F
I
PLL
I
fig|316385.7.peg.3688
Escherichia coli str. K-12 substr. DH10B (540-893/911)
LR
RLFS
Y
SR
R
E
A
L
E
L
R
RDP
VRSTLALMGT
V
I
L
M
L
I
M
G
Y
GI
S
M
---------
D
V
E
N
L
R
F
A
V
L
D
R
DQ
TVS
S
QAW
T
LN
L
S
G
SRY
F
IEQ
P
P
L
T
S
Y
DE
L
D
RR
M
R
AG
DI
T
V
AI
E
IPPNF
G
R
--
D
IAR
G
T
P
V
E
L
G
V
W
I
DG
AMP
S
R
A
E
T
VK
GY
V
Q
A
M
HQSWL
Q
DVAS
R
QST
P
A
SQS
G
L
M
NI
ETR
Y
RYNP
DVK
SL
PA
I
VP
A
VI
P
L
L
--
L
M
M
IPS
M
L
S
A
LSV
V
RE
K
E
L
G
S
I
IN
L
Y
V
T
P
T
T
RS
E
F
L
L
GK
-
---
Q
LP
Y
I
A
L
GM
L
NFF
L
L
CGLSVF
V
F
GVP
HK
GS
FL
TL
T
L
AAL
LY
IIIA
TG
M
GLLIST
FMK
SQ
I
A
A
IF
G
T
A
I
I
T
L
I
PA
TQ
F
SG
MID
PV
A
S
LEGPG
R
W
I
G
E
---VY
PT
S
HF
LT
IA
R
G
T
FS
K
A
L
D
L
T
DL
W
QL
F
I
PLL
I
fig|511145.12.peg.3585
Escherichia coli str. K-12 substr. MG1655 (540-893/911)
LR
RLFS
Y
SR
R
E
A
L
E
L
R
RDP
VRSTLALMGT
V
I
L
M
L
I
M
G
Y
GI
S
M
---------
D
V
E
N
L
R
F
A
V
L
D
R
DQ
TVS
S
QAW
T
LN
L
S
G
SRY
F
IEQ
P
P
L
T
S
Y
DE
L
D
RR
M
R
AG
DI
T
V
AI
E
IPPNF
G
R
--
D
IAR
G
T
P
V
E
L
G
V
W
I
DG
AMP
S
R
A
E
T
VK
GY
V
Q
A
M
HQSWL
Q
DVAS
R
QST
P
A
SQS
G
L
M
NI
ETR
Y
RYNP
DVK
SL
PA
I
VP
A
VI
P
L
L
--
L
M
M
IPS
M
L
S
A
LSV
V
RE
K
E
L
G
S
I
IN
L
Y
V
T
P
T
T
RS
E
F
L
L
GK
-
---
Q
LP
Y
I
A
L
GM
L
NFF
L
L
CGLSVF
V
F
GVP
HK
GS
FL
TL
T
L
AAL
LY
IIIA
TG
M
GLLIST
FMK
SQ
I
A
A
IF
G
T
A
I
I
T
L
I
PA
TQ
F
SG
MID
PV
A
S
LEGPG
R
W
I
G
E
---VY
PT
S
HF
LT
IA
R
G
T
FS
K
A
L
D
L
T
DL
W
QL
F
I
PLL
I
fig|511145.6.peg.3568
Escherichia coli str. K-12 substr. MG1655 (540-893/911)
LR
RLFS
Y
SR
R
E
A
L
E
L
R
RDP
VRSTLALMGT
V
I
L
M
L
I
M
G
Y
GI
S
M
---------
D
V
E
N
L
R
F
A
V
L
D
R
DQ
TVS
S
QAW
T
LN
L
S
G
SRY
F
IEQ
P
P
L
T
S
Y
DE
L
D
RR
M
R
AG
DI
T
V
AI
E
IPPNF
G
R
--
D
IAR
G
T
P
V
E
L
G
V
W
I
DG
AMP
S
R
A
E
T
VK
GY
V
Q
A
M
HQSWL
Q
DVAS
R
QST
P
A
SQS
G
L
M
NI
ETR
Y
RYNP
DVK
SL
PA
I
VP
A
VI
P
L
L
--
L
M
M
IPS
M
L
S
A
LSV
V
RE
K
E
L
G
S
I
IN
L
Y
V
T
P
T
T
RS
E
F
L
L
GK
-
---
Q
LP
Y
I
A
L
GM
L
NFF
L
L
CGLSVF
V
F
GVP
HK
GS
FL
TL
T
L
AAL
LY
IIIA
TG
M
GLLIST
FMK
SQ
I
A
A
IF
G
T
A
I
I
T
L
I
PA
TQ
F
SG
MID
PV
A
S
LEGPG
R
W
I
G
E
---VY
PT
S
HF
LT
IA
R
G
T
FS
K
A
L
D
L
T
DL
W
QL
F
I
PLL
I
fig|83333.1.peg.3419
Escherichia coli K12 (523-876/894)
LR
RLFS
Y
SR
R
E
A
L
E
L
R
RDP
VRSTLALMGT
V
I
L
M
L
I
M
G
Y
GI
S
M
---------
D
V
E
N
L
R
F
A
V
L
D
R
DQ
TVS
S
QAW
T
LN
L
S
G
SRY
F
IEQ
P
P
L
T
S
Y
DE
L
D
RR
M
R
AG
DI
T
V
AI
E
IPPNF
G
R
--
D
IAR
G
T
P
V
E
L
G
V
W
I
DG
AMP
S
R
A
E
T
VK
GY
V
Q
A
M
HQSWL
Q
DVAS
R
QST
P
A
SQS
G
L
M
NI
ETR
Y
RYNP
DVK
SL
PA
I
VP
A
VI
P
L
L
--
L
M
M
IPS
M
L
S
A
LSV
V
RE
K
E
L
G
S
I
IN
L
Y
V
T
P
T
T
RS
E
F
L
L
GK
-
---
Q
LP
Y
I
A
L
GM
L
NFF
L
L
CGLSVF
V
F
GVP
HK
GS
FL
TL
T
L
AAL
LY
IIIA
TG
M
GLLIST
FMK
SQ
I
A
A
IF
G
T
A
I
I
T
L
I
PA
TQ
F
SG
MID
PV
A
S
LEGPG
R
W
I
G
E
---VY
PT
S
HF
LT
IA
R
G
T
FS
K
A
L
D
L
T
DL
W
QL
F
I
PLL
I
fig|749547.3.peg.1957
Escherichia coli MS 187-1 (540-893/911)
LR
RLFS
Y
SR
R
E
A
L
E
L
R
RDP
VRSTLALMGT
V
I
L
M
L
I
M
G
Y
GI
S
M
---------
D
V
E
N
L
R
F
A
V
L
D
R
DQ
TVS
S
QAW
T
LN
L
S
G
SRY
F
IEQ
P
P
L
T
S
Y
DE
L
D
RR
M
R
AG
DI
T
V
AI
E
IPPNF
G
R
--
D
IAR
G
T
P
V
E
L
G
V
W
I
DG
AMP
S
R
A
E
T
VK
GY
V
Q
A
M
HQSWL
Q
DVAS
R
QST
P
A
SQS
G
L
M
NI
ETR
Y
RYNP
DVK
SL
PA
I
VP
A
VI
P
L
L
--
L
M
M
IPS
M
L
S
A
LSV
V
RE
K
E
L
G
S
I
IN
L
Y
V
T
P
T
T
RS
E
F
L
L
GK
-
---
Q
LP
Y
I
A
L
GM
L
NFF
L
L
CGLSVF
V
F
GVP
HK
GS
FL
TL
T
L
AAL
LY
IIIA
TG
M
GLLIST
FMK
SQ
I
A
A
IF
G
T
A
I
I
T
L
I
PA
TQ
F
SG
MID
PV
A
S
LEGPG
R
W
I
G
E
---VY
PT
S
HF
LT
IA
R
G
T
FS
K
A
L
D
L
T
DL
W
QL
F
I
PLL
I
fig|656444.3.peg.4757
Escherichia coli TA280 (540-893/911)
LR
RLFS
Y
SR
R
E
A
L
E
L
R
RDP
VRSTLALMGT
V
I
L
M
L
I
M
G
Y
GI
S
M
---------
D
V
E
N
L
R
F
A
V
L
D
R
DQ
TVS
S
QAW
T
LN
L
S
G
SRY
F
IEQ
P
P
L
T
S
Y
DE
L
D
RR
M
R
AG
DI
T
V
AI
E
IPPNF
G
R
--
D
IAR
G
T
P
V
E
L
G
V
W
I
DG
AMP
S
R
A
E
T
VK
GY
V
Q
A
M
HQSWL
Q
DVAS
R
QST
P
A
SQ
N
G
L
M
NI
ETR
Y
RYNP
DVK
SL
PA
I
VP
A
VI
P
L
L
--
L
M
M
IPS
M
L
S
A
LSV
V
RE
K
E
L
G
S
I
IN
L
Y
V
T
P
T
T
RS
E
F
L
L
GK
-
---
Q
LP
Y
I
A
L
GM
L
NFF
L
L
CGLSVF
V
F
GVP
HK
GS
FL
TL
T
L
AAL
LY
IIIA
TG
M
GLLIST
FMK
SQ
I
A
A
IF
G
T
A
I
I
T
L
I
PA
TQ
F
SG
MID
PV
A
S
LEGPG
R
W
I
G
E
---VY
PT
S
HF
LT
IA
R
G
T
FS
K
A
L
D
L
T
DL
W
QL
F
I
PLL
I
fig|316401.4.peg.4228
Escherichia coli ETEC H10407 (540-893/911)
LR
RLFS
Y
SR
R
E
A
L
E
L
R
RDP
VRSTLALMGT
V
I
L
M
L
I
M
G
Y
GI
S
M
---------
D
V
E
N
L
R
F
A
V
L
D
R
DQ
TVS
S
QAW
T
LN
L
S
G
SRY
F
IEQ
P
P
L
T
S
Y
DE
L
D
RR
M
R
AG
DI
T
V
AI
E
IPPNF
G
R
--
D
IAR
G
T
P
V
E
L
G
V
W
I
DG
AMP
S
R
A
E
T
VK
GY
V
Q
A
M
HQSWL
Q
DVAS
R
QST
P
A
SQS
G
L
M
NI
ETR
Y
RYNP
DVK
SL
PA
I
VP
A
VI
P
L
L
--
L
M
M
IPS
M
L
S
A
LSV
V
RE
K
E
L
G
S
I
IN
L
Y
V
T
P
T
T
RS
E
F
L
L
GK
-
---
Q
LP
Y
I
A
L
GL
L
NFF
L
L
CGLSVF
V
F
GVP
HK
GS
FL
TL
T
L
AAL
LY
IIIA
TG
M
GLLIST
FMK
SQ
I
A
A
IF
G
T
A
I
I
T
L
I
PA
TQ
F
SG
MID
PV
A
S
LEGPG
R
W
I
G
E
---VY
PT
S
HF
LT
IA
R
G
T
FS
K
A
L
D
L
T
DL
W
QL
F
I
PLL
I
fig|749537.3.peg.610
Escherichia coli MS 115-1 (540-893/911)
LR
RLFS
Y
SR
R
E
A
L
E
L
R
RDP
VRSTLALMGT
V
I
L
M
L
I
M
G
Y
GI
S
M
---------
D
V
E
N
L
R
F
A
V
L
D
R
DQ
TVS
S
QAW
T
LN
L
S
G
SRY
F
IEQ
P
P
L
T
S
Y
DE
L
D
RR
M
R
AG
DI
T
V
AI
E
IPPNF
G
R
--
D
IAR
G
T
P
V
E
L
G
V
W
I
DG
AMP
S
R
A
E
T
VK
GY
V
Q
A
M
HQSWL
Q
DVAS
R
QST
P
A
SQS
G
L
M
NI
ETR
Y
RYNP
DVK
SL
PA
I
VP
A
VI
P
L
L
--
L
M
M
IPS
M
L
S
A
LSV
V
RE
K
E
L
G
S
I
IN
L
Y
V
T
P
T
T
RS
E
F
L
L
GK
-
---
Q
LP
Y
I
A
L
GM
L
NFF
L
L
CGLSVF
V
F
GVP
HK
GS
FL
TL
T
L
AAL
LY
IIIA
TG
M
GLLIST
FMK
SQ
I
A
A
IF
G
T
A
I
I
T
L
I
PA
TQ
F
SG
MID
PV
A
S
LEGPG
R
W
I
G
E
---VY
PT
S
HF
LT
IA
R
G
T
FS
K
A
L
D
L
A
DL
W
QL
F
I
PLL
I
fig|550672.3.peg.3530
Escherichia coli B088 (484-837/855)
LR
RLFS
Y
SR
R
E
A
L
E
L
R
RDP
VRSTLALMGT
V
I
L
M
L
I
M
G
Y
GI
S
M
---------
D
V
E
N
L
R
F
A
V
L
D
R
DQ
TVS
S
QAW
T
LN
L
S
G
SRY
F
IEQ
P
P
L
T
S
Y
DE
L
D
RR
M
R
AG
DI
T
V
AI
E
IPPNF
G
R
--
D
IAR
G
T
P
V
E
L
G
V
W
I
DG
AMP
S
R
A
E
T
VK
GY
V
Q
A
M
HQSWL
Q
DVAS
R
QST
P
A
SQS
G
L
M
NI
ETR
Y
RYNP
DVK
SL
PA
I
VP
A
VI
P
L
L
--
L
M
M
IPS
M
L
S
A
LSV
V
RE
K
E
L
G
S
I
IN
L
Y
V
T
P
T
T
RS
E
F
L
L
GK
-
---
Q
LP
Y
I
S
L
GM
L
NFF
L
L
CGLSVF
V
F
GVP
HK
GS
FL
TL
T
L
AAL
LY
IIIA
TG
M
GLLIST
FMK
SQ
I
A
A
IF
G
T
A
I
I
T
L
I
PA
TQ
F
SG
MID
PV
A
S
LEGPG
R
W
I
G
E
---VY
PT
S
HF
LT
IA
R
G
T
FS
K
A
L
D
L
T
DL
W
QL
F
I
PLL
I
fig|679207.4.peg.325
Escherichia coli MS 107-1 (540-893/911)
LR
RLFS
Y
SR
R
E
A
L
E
L
R
RDP
VRSTLALMGT
V
I
L
M
L
I
M
G
Y
GI
S
M
---------
D
V
E
N
L
R
F
A
V
L
D
R
DQ
TVS
S
QAW
T
LN
L
S
G
SRY
F
IEQ
P
P
L
T
S
Y
DE
L
D
RR
M
R
AG
DI
T
V
AI
E
IPPNF
G
R
--
D
IAR
G
T
P
V
E
L
G
V
W
I
DG
AMP
S
R
A
E
T
VK
GY
V
Q
A
M
HQSWL
Q
DVAS
R
QST
P
A
SQS
G
L
M
NI
ETR
Y
RYNP
DVK
SL
PA
I
VP
A
VI
P
L
L
--
L
M
M
IPS
M
L
S
A
LSV
V
RE
K
E
L
G
S
I
IN
L
Y
V
T
P
T
T
RS
E
F
L
L
GK
-
---
Q
LP
Y
I
S
L
GM
L
NFF
L
L
CGLSVF
V
F
GVP
HK
GS
FL
TL
T
L
AAL
LY
IIIA
TG
M
GLLIST
FMK
SQ
I
A
A
IF
G
T
A
I
I
T
L
I
PA
TQ
F
SG
MID
PV
A
S
LEGPG
R
W
I
G
E
---VY
PT
S
HF
LT
IA
R
G
T
FS
K
A
L
D
L
T
DL
W
QL
F
I
PLL
I
fig|670888.3.peg.2762
Escherichia coli 1827-70 (540-893/911)
LR
RLFS
Y
SR
R
E
A
L
E
L
R
RDP
VRSTLALMGT
V
I
L
M
L
I
M
G
Y
GI
S
M
---------
D
V
E
N
L
R
F
A
V
L
D
R
DQ
TVS
S
QAW
T
LN
L
S
G
SRY
F
IEQ
P
P
L
T
S
Y
DE
L
D
RR
M
R
AG
DI
T
V
AI
E
IPPNF
G
R
--
D
IAR
G
T
P
V
E
L
G
V
W
I
DG
AMP
S
R
A
E
T
VK
GY
V
Q
A
M
HQSWL
Q
DVAS
R
QST
P
A
SQS
G
L
M
NI
ETR
Y
RYNP
DVK
SL
PA
I
VP
A
VI
P
L
L
--
L
M
M
IPS
M
L
S
A
LSV
V
RE
K
E
L
G
S
I
IN
L
Y
V
T
P
T
T
RS
E
F
L
L
GK
-
---
Q
LP
Y
I
A
L
GM
L
NFF
L
L
CGLSVF
V
F
GVP
HK
GS
FL
TL
T
L
AAL
LY
IIIA
TG
M
GLLIST
FMK
SQ
I
A
A
IF
G
T
A
I
I
T
L
I
PA
TQ
F
SG
MID
PV
A
S
LEGPG
R
W
I
G
E
---VY
PT
S
HF
LI
IA
R
G
T
FS
K
A
L
D
L
T
DL
W
QL
F
I
PLL
I
fig|481805.3.peg.241
Escherichia coli ATCC 8739 (540-893/911)
LR
RLFS
Y
SR
R
E
A
L
E
L
R
RDP
VRSTLALMGT
V
I
L
M
L
I
M
G
Y
GI
S
M
---------
D
V
E
N
L
R
F
A
V
L
D
R
DQ
TVS
S
QAW
T
LN
L
S
G
SRY
F
IEQ
P
P
L
T
S
Y
DE
L
D
RR
M
R
AG
DI
T
V
AI
E
IPPNF
G
R
--
D
IAR
G
T
P
V
E
L
G
V
W
I
DG
AMP
S
R
A
E
T
VK
GY
V
Q
A
M
HQSWL
Q
DVAS
R
QST
P
A
SQS
G
L
M
NI
ETR
Y
RYNP
DVK
SL
PA
I
VP
A
VI
P
L
L
--
L
M
M
IPS
M
L
S
A
LSV
V
RE
K
E
L
G
S
I
IN
L
Y
V
T
P
T
T
RS
E
F
L
L
GK
-
---
Q
LP
Y
I
A
L
GM
L
NFF
L
L
CGLSVF
V
F
GVP
HK
GS
FL
TL
T
L
AAL
LY
IIIA
TG
M
GLLIST
FMK
SQ
I
A
A
IF
G
T
A
I
I
T
L
I
PA
TQ
F
SG
MID
PV
A
S
LEGPG
R
W
I
G
E
---VY
PT
S
HF
LI
IA
R
G
T
FS
K
A
L
D
L
T
DL
W
QL
F
I
PLL
I
fig|481805.6.peg.251
Escherichia coli ATCC 8739 (540-893/911)
LR
RLFS
Y
SR
R
E
A
L
E
L
R
RDP
VRSTLALMGT
V
I
L
M
L
I
M
G
Y
GI
S
M
---------
D
V
E
N
L
R
F
A
V
L
D
R
DQ
TVS
S
QAW
T
LN
L
S
G
SRY
F
IEQ
P
P
L
T
S
Y
DE
L
D
RR
M
R
AG
DI
T
V
AI
E
IPPNF
G
R
--
D
IAR
G
T
P
V
E
L
G
V
W
I
DG
AMP
S
R
A
E
T
VK
GY
V
Q
A
M
HQSWL
Q
DVAS
R
QST
P
A
SQS
G
L
M
NI
ETR
Y
RYNP
DVK
SL
PA
I
VP
A
VI
P
L
L
--
L
M
M
IPS
M
L
S
A
LSV
V
RE
K
E
L
G
S
I
IN
L
Y
V
T
P
T
T
RS
E
F
L
L
GK
-
---
Q
LP
Y
I
A
L
GM
L
NFF
L
L
CGLSVF
V
F
GVP
HK
GS
FL
TL
T
L
AAL
LY
IIIA
TG
M
GLLIST
FMK
SQ
I
A
A
IF
G
T
A
I
I
T
L
I
PA
TQ
F
SG
MID
PV
A
S
LEGPG
R
W
I
G
E
---VY
PT
S
HF
LI
IA
R
G
T
FS
K
A
L
D
L
T
DL
W
QL
F
I
PLL
I
fig|331112.3.peg.3457
Escherichia coli HS (540-893/911)
LR
RLFS
Y
SR
R
E
A
L
E
L
R
RDP
VRSTLALMGT
V
I
L
M
L
I
M
G
Y
GI
S
M
---------
D
V
E
N
L
R
F
A
V
L
D
R
DQ
TVS
S
QAW
T
LN
L
S
G
SRY
F
IEQ
P
P
L
T
S
Y
DE
L
D
RR
M
R
AG
DI
T
V
AI
E
IPPNF
G
R
--
D
IAR
G
T
P
V
E
L
G
V
W
I
DG
AMP
S
R
A
E
T
VK
GY
V
Q
A
M
HQSWL
Q
DVAS
R
QST
P
A
SQS
G
L
M
NI
ETR
Y
RYNP
DVK
SL
PA
I
VP
A
VI
P
L
L
--
L
M
M
IPS
M
L
S
A
LSV
V
RE
K
E
L
G
S
I
IN
L
Y
V
T
P
T
T
RS
E
F
L
L
GK
-
---
Q
LP
Y
I
A
L
GM
L
NFF
L
L
CGLSVF
V
F
GVP
HK
GS
FL
TL
T
L
AAL
LY
IIIA
TG
M
GLLIST
FMK
SQ
I
A
A
IF
G
T
A
I
I
T
L
I
PA
TQ
F
SG
MID
PV
A
S
LEGPG
R
W
I
G
E
---VY
PT
S
HF
LI
IA
R
G
T
FS
K
A
L
D
L
T
DL
W
QL
F
I
PLL
I
fig|331112.6.peg.3592
Escherichia coli HS (540-893/911)
LR
RLFS
Y
SR
R
E
A
L
E
L
R
RDP
VRSTLALMGT
V
I
L
M
L
I
M
G
Y
GI
S
M
---------
D
V
E
N
L
R
F
A
V
L
D
R
DQ
TVS
S
QAW
T
LN
L
S
G
SRY
F
IEQ
P
P
L
T
S
Y
DE
L
D
RR
M
R
AG
DI
T
V
AI
E
IPPNF
G
R
--
D
IAR
G
T
P
V
E
L
G
V
W
I
DG
AMP
S
R
A
E
T
VK
GY
V
Q
A
M
HQSWL
Q
DVAS
R
QST
P
A
SQS
G
L
M
NI
ETR
Y
RYNP
DVK
SL
PA
I
VP
A
VI
P
L
L
--
L
M
M
IPS
M
L
S
A
LSV
V
RE
K
E
L
G
S
I
IN
L
Y
V
T
P
T
T
RS
E
F
L
L
GK
-
---
Q
LP
Y
I
A
L
GM
L
NFF
L
L
CGLSVF
V
F
GVP
HK
GS
FL
TL
T
L
AAL
LY
IIIA
TG
M
GLLIST
FMK
SQ
I
A
A
IF
G
T
A
I
I
T
L
I
PA
TQ
F
SG
MID
PV
A
S
LEGPG
R
W
I
G
E
---VY
PT
S
HF
LI
IA
R
G
T
FS
K
A
L
D
L
T
DL
W
QL
F
I
PLL
I
fig|749528.3.peg.3035
Escherichia coli MS 45-1 (540-893/911)
LR
RLFS
Y
SR
R
E
A
L
E
L
R
RDP
VRSTLALMGT
V
I
L
M
L
I
M
G
Y
GI
S
M
---------
D
V
E
N
L
R
F
A
V
L
D
R
DQ
TVS
S
QAW
T
LN
L
S
G
SRY
F
IEQ
P
P
L
T
S
Y
DE
L
D
RR
M
R
AG
DI
T
V
AI
E
IPPNF
G
R
--
D
IAR
G
T
P
V
E
L
G
V
W
I
DG
AMP
S
R
A
E
T
VK
GY
V
Q
A
M
HQSWL
Q
DVAS
R
QST
P
A
SQS
G
L
M
NI
ETR
Y
RYNP
DVK
SL
PA
I
VP
A
VI
P
L
L
--
L
M
M
IPS
M
L
S
A
LSV
V
RE
K
E
L
G
S
I
IN
L
Y
V
T
P
T
T
RS
E
F
L
L
GK
-
---
Q
LP
Y
I
A
L
GM
L
NFF
L
L
CALSVF
V
F
GVP
HK
G
I
FL
TL
T
L
AAL
LY
IIIA
TG
M
GLLIST
FMK
SQ
I
A
A
IF
G
T
A
I
I
T
L
I
PA
TQ
F
SG
MID
PV
A
S
LEGPG
R
W
I
G
E
---VY
PT
S
HF
LT
IA
R
G
T
FS
K
A
L
D
L
T
DL
W
QL
F
I
PLL
I
fig|585396.4.peg.4443
Escherichia coli O111:H- str. 11128 (540-893/911)
LR
RLFS
Y
SR
R
E
A
L
E
L
R
RDP
VRSTLALMGT
V
I
L
M
L
I
M
G
Y
GI
S
M
---------
D
V
E
N
L
R
F
S
V
L
D
R
DQ
TVS
S
QAW
T
LN
L
S
G
SRY
F
IEQ
P
P
L
T
S
Y
DE
L
D
RR
M
R
AG
DI
T
V
AI
E
IPPNF
G
R
--
D
IAR
G
T
P
V
E
L
G
V
W
I
DG
AMP
S
R
A
E
T
VK
GY
V
Q
A
M
HQSWL
Q
DVAS
R
QST
P
A
SQS
G
L
M
NI
ETR
Y
RYNP
DVK
SL
PA
I
VP
A
VI
P
L
L
--
L
M
M
IPS
M
L
S
A
LSV
V
RE
K
E
L
G
S
I
IN
L
Y
V
T
P
T
T
RS
E
F
L
L
GK
-
---
Q
LP
Y
I
A
L
GM
L
NFF
L
L
CGLSVF
V
F
GVP
HK
GS
FL
TL
T
L
AAL
LY
IIIA
TG
M
GLLIST
FMK
SQ
I
A
A
IF
G
T
A
I
I
T
L
I
PA
TQ
F
SG
MID
PV
A
S
LEGPG
R
W
I
G
E
---VY
PT
S
HF
LT
IA
R
G
T
FS
K
A
L
D
L
T
DL
W
QL
F
I
PLL
I
fig|679204.3.peg.4570
Escherichia coli MS 145-7 (540-893/911)
LR
RLFS
Y
SR
R
E
A
L
E
L
R
RDP
VRSTLALMGT
V
I
L
M
L
I
M
G
Y
GI
S
M
---------
D
V
E
N
L
R
F
A
V
L
D
R
DQ
TVS
S
QAW
T
LN
L
S
G
SRY
F
IEQ
P
P
L
T
S
Y
DE
L
D
RR
M
R
AG
DI
T
V
AI
E
N
PPNF
G
R
--
D
IAR
G
T
P
V
E
L
G
V
W
I
DG
AMP
S
R
A
E
T
VK
GY
V
Q
A
M
HQSWL
Q
DVAS
R
QST
P
A
SQS
G
L
M
NI
ETR
Y
RYNP
DVK
SL
PA
I
VP
A
VI
P
L
L
--
L
M
M
IPS
M
L
S
A
LSV
V
RE
K
E
L
G
S
I
IN
L
Y
V
T
P
T
T
RS
E
F
L
L
GK
-
---
Q
LP
Y
I
A
L
GM
L
NFF
L
L
CGLSVF
V
F
GVP
HK
GS
FL
TL
T
L
AAL
LY
IIIA
TG
M
GLLIST
FMK
SQ
I
A
A
IF
G
T
A
I
I
T
L
I
PA
TQ
F
SG
MID
PV
A
S
LEGPG
R
W
I
G
E
---VY
PT
S
HF
LT
IA
R
G
T
FS
K
A
L
D
L
T
DL
W
QL
F
I
PLL
I
fig|340186.3.peg.4735
Escherichia coli E110019 (540-893/911)
LR
RLFS
Y
SR
R
E
A
L
E
L
R
RDP
VRSTLALMGT
V
I
L
M
L
I
M
G
Y
GI
S
M
---------
D
V
E
N
L
R
F
A
V
L
D
R
DQ
TVS
S
QAW
T
LN
L
S
G
SRY
F
IEQ
P
P
L
T
S
Y
DE
L
D
RR
M
R
AG
DI
T
V
AI
E
IPPNF
G
R
--
D
IAR
G
T
P
V
E
L
G
V
W
I
DG
AMP
S
R
A
E
T
VK
GY
V
Q
A
M
HQSWL
Q
DVAS
R
QST
T
V
SQS
G
L
M
NI
ETR
Y
RYNP
DVK
SL
PA
I
VP
A
VI
P
L
L
--
L
M
M
IPS
M
L
S
A
LSV
V
RE
K
E
L
G
S
I
IN
L
Y
V
T
P
T
T
RS
E
F
L
L
GK
-
---
Q
LP
Y
I
A
L
GM
L
NFF
L
L
CGLSVF
V
F
GVP
HK
GS
FL
TL
T
L
AAL
LY
IIIA
TG
M
GLLIST
FMK
SQ
I
A
A
IF
G
T
A
I
I
T
L
I
PA
TQ
F
SG
MID
PV
A
S
LEGPG
R
W
I
G
E
---VY
PT
S
HF
LT
IA
R
G
T
FS
K
A
L
D
L
T
DL
W
QL
F
I
PLL
I
fig|340186.5.peg.4995
Escherichia coli E110019 (540-893/911)
LR
RLFS
Y
SR
R
E
A
L
E
L
R
RDP
VRSTLALMGT
V
I
L
M
L
I
M
G
Y
GI
S
M
---------
D
V
E
N
L
R
F
A
V
L
D
R
DQ
TVS
S
QAW
T
LN
L
S
G
SRY
F
IEQ
P
P
L
T
S
Y
DE
L
D
RR
M
R
AG
DI
T
V
AI
E
IPPNF
G
R
--
D
IAR
G
T
P
V
E
L
G
V
W
I
DG
AMP
S
R
A
E
T
VK
GY
V
Q
A
M
HQSWL
Q
DVAS
R
QST
T
V
SQS
G
L
M
NI
ETR
Y
RYNP
DVK
SL
PA
I
VP
A
VI
P
L
L
--
L
M
M
IPS
M
L
S
A
LSV
V
RE
K
E
L
G
S
I
IN
L
Y
V
T
P
T
T
RS
E
F
L
L
GK
-
---
Q
LP
Y
I
A
L
GM
L
NFF
L
L
CGLSVF
V
F
GVP
HK
GS
FL
TL
T
L
AAL
LY
IIIA
TG
M
GLLIST
FMK
SQ
I
A
A
IF
G
T
A
I
I
T
L
I
PA
TQ
F
SG
MID
PV
A
S
LEGPG
R
W
I
G
E
---VY
PT
S
HF
LT
IA
R
G
T
FS
K
A
L
D
L
T
DL
W
QL
F
I
PLL
I
fig|550677.3.peg.4034
Escherichia coli B354 (13-370/374)
KEL
R
SLL
G
D
-
--------KA
M
L
T
LIVF
S
F
TV
SV
YSSATVTPG
S
L
N
L
A
P
IAI
A
D
M
DQ
SQL
S
NRI
V
NS
F
Y
R
PWF
L
--P
P
E
M
I
T
P
DEMD
AG
LDAG
RY
T
F
AI
N
IPPNF
Q
R
--
D
VLA
G
R
Q
P
D
I
Q
V
N
VD
A
TRM
S
Q
A
F
T
GN
GYIQ
N
I
INGEV
N
SFVA
R
YR-
-
D
NSE
P
LV
SL
ETR
M
R
F
NPNLD
PA
WF
-
-
G
G
V
M
AII
NN
I
TM
LAI
VLT
G
SAL
I
RERE
H
GTV
EH
LLV
M
P
I
T
PF
EI
M
M
A
K
V
WSM
G
L
V
V
L
V
V
SG
L
SLV
LM
VK---G
V
L
GVP
IE
GS
IP
LF
M
L
GVA
L
S
LFAT
T
S
I
G
IFMG
T
IAR
S
M
P
Q
L
GL
L
V
I
L
V
-
LLP
L
QM
LSG
GST
P
R
ESMP
---
Q
M
VQD
IMLTM
PT
T
HF
VS
L
AQ
A
I
LY
R
G
A
G
F
E
IVW
PQ
F
L
T
L
M
A
IGGAFFTIA
L
LRFRKTI
fig|216592.1.peg.734
Escherichia coli 042 (41-398/402)
KEL
R
SLL
G
D
-
--------KA
M
L
T
LIVF
S
F
TV
SV
YSSATVTPG
S
L
N
L
A
P
IAI
A
D
M
DQ
SQL
S
NRI
V
NS
F
Y
R
PWF
L
--P
P
E
M
I
T
A
DEMD
AG
LDAG
RY
T
F
AI
N
IPPNF
Q
R
--
D
VLA
G
R
Q
P
D
I
Q
V
N
VD
A
TRM
S
Q
A
F
T
GN
GYIQ
N
I
INGEV
N
SFVA
R
YR-
-
D
NSE
P
LV
SL
ETR
M
R
F
NPNLD
PA
WF
-
-
G
G
V
M
AII
NN
I
TM
LAI
VLT
G
SAL
I
RERE
H
GTV
EH
LLV
M
P
I
T
PF
EI
M
M
A
K
I
WSM
G
L
V
V
L
V
V
SG
L
SLV
LM
VK---G
V
L
GVP
IE
GS
IP
LF
M
L
GVA
L
S
LFAT
T
S
I
G
IFMG
T
IAR
S
M
P
Q
L
GL
L
V
I
L
V
-
LLP
L
QM
LSG
GST
P
R
ESMP
---
Q
M
VQD
IMLTM
PT
T
HF
VS
L
AQ
A
I
LY
R
G
A
G
F
E
IVW
SQ
F
L
T
L
M
A
IGGAFFTIA
L
LRFRKTI
fig|405955.9.peg.3282
Escherichia coli APEC O1 (41-398/402)
KEL
R
SLL
G
D
-
--------KA
M
L
T
LIVF
S
F
TV
SV
YSSATVTPG
S
L
N
F
A
P
IAI
A
D
M
DQ
SQL
S
NRI
V
NS
F
Y
R
PWF
L
--P
P
E
M
I
T
A
DEMD
AG
LDAG
RY
T
F
AI
N
IPPNF
Q
R
--
D
VLA
G
R
Q
P
D
I
Q
V
N
VD
A
TRM
S
Q
A
F
T
GN
GYIQ
N
I
INGEV
N
SFVA
R
YR-
-
D
NSE
P
LV
SL
ETR
M
R
F
NPNLD
PA
WF
-
-
G
G
V
M
AII
NN
I
TM
LAI
VLT
G
SAL
I
RERE
H
GTV
EH
LLV
M
P
I
T
PF
EI
M
M
A
K
V
WSM
G
L
V
V
L
V
V
SG
L
SLV
LM
VK---G
V
L
GVP
IE
GS
IP
LF
M
L
GVA
L
S
LFAT
T
S
I
G
IFMG
T
IAR
S
M
P
Q
L
GL
L
V
I
L
V
-
LLP
L
QM
LSG
GST
P
R
ESMP
---
Q
M
VQD
IMLTM
PT
T
HF
VS
L
AQ
A
I
LY
R
G
A
G
F
E
IVW
PQ
F
L
T
L
M
A
IGGAFFTIA
L
LRFRKTI
fig|155864.1.peg.4365
Escherichia coli O157:H7 EDL933 (14-371/375)
KEL
R
SLL
G
D
-
--------KA
M
L
T
LIVF
S
F
TV
SV
YSSATVTPG
S
L
N
L
A
P
IAI
A
D
M
DQ
SQL
S
NRI
V
NS
F
Y
R
PWF
L
--P
P
E
M
I
T
A
DEMD
AG
LDAG
RY
T
F
AI
N
IPPNF
Q
R
--
D
VLA
G
R
Q
P
D
I
Q
V
N
VD
A
TRM
S
Q
A
F
T
GN
GYIQ
N
I
INGEV
N
SFVA
R
YR-
-
D
NSE
P
LV
SL
ETR
M
R
F
NPNLD
PA
WF
-
-
G
G
V
M
AII
NN
I
TM
LAI
VLT
G
SAL
I
RERE
H
GTV
EH
LLV
M
P
I
T
PF
EI
M
M
A
K
I
WSM
G
L
V
V
L
V
V
SG
L
SLV
LM
VK---G
V
L
GVP
IE
GS
IP
LF
M
L
GVA
L
S
LFAT
T
S
I
G
IFMG
T
IAR
S
M
P
Q
L
GL
L
V
I
L
V
-
LLP
L
QM
LSG
GST
P
R
ESMP
---
Q
M
VQD
IMLIM
PT
T
HF
VS
L
AQ
A
I
LY
R
G
A
G
F
E
IVW
PQ
F
L
T
L
M
A
IGGAFFTIA
L
LRFRKTI
fig|562.371.peg.3346
Escherichia coli 1044A (13-370/374)
KEL
R
SLL
G
D
-
--------KA
M
L
T
LIVF
S
F
TV
SV
YSSATVTPG
S
L
N
L
A
P
IAI
A
D
M
DQ
SQL
S
NRI
V
NS
F
Y
R
PWF
L
--P
P
E
M
I
T
A
DEMD
AG
LDAG
RY
T
F
AI
N
IPPNF
Q
R
--
D
VLA
G
R
Q
P
D
I
Q
V
N
VD
A
TRM
S
Q
A
F
T
GN
GYIQ
N
I
INGEV
N
SFVA
R
YR-
-
D
NSE
P
LV
SL
ETR
M
R
F
NPNLD
PA
WF
-
-
G
G
V
M
AII
NN
I
TM
LAI
VLT
G
SAL
I
RERE
H
GTV
EH
LLV
M
P
I
T
PF
EI
M
M
A
K
I
WSM
G
L
V
V
L
V
V
SG
L
SLV
LM
VK---G
V
L
GVP
IE
GS
IP
LF
M
L
GVA
L
S
LFAT
T
S
I
G
IFMG
T
IAR
S
M
P
Q
L
GL
L
V
I
L
V
-
LLP
L
QM
LSG
GST
P
R
ESMP
---
Q
M
VQD
IMLIM
PT
T
HF
VS
L
AQ
A
I
LY
R
G
A
G
F
E
IVW
PQ
F
L
T
L
M
A
IGGAFFTIA
L
LRFRKTI
fig|562.373.peg.1503
Escherichia coli 1125A (13-370/374)
KEL
R
SLL
G
D
-
--------KA
M
L
T
LIVF
S
F
TV
SV
YSSATVTPG
S
L
N
L
A
P
IAI
A
D
M
DQ
SQL
S
NRI
V
NS
F
Y
R
PWF
L
--P
P
E
M
I
T
A
DEMD
AG
LDAG
RY
T
F
AI
N
IPPNF
Q
R
--
D
VLA
G
R
Q
P
D
I
Q
V
N
VD
A
TRM
S
Q
A
F
T
GN
GYIQ
N
I
INGEV
N
SFVA
R
YR-
-
D
NSE
P
LV
SL
ETR
M
R
F
NPNLD
PA
WF
-
-
G
G
V
M
AII
NN
I
TM
LAI
VLT
G
SAL
I
RERE
H
GTV
EH
LLV
M
P
I
T
PF
EI
M
M
A
K
I
WSM
G
L
V
V
L
V
V
SG
L
SLV
LM
VK---G
V
L
GVP
IE
GS
IP
LF
M
L
GVA
L
S
LFAT
T
S
I
G
IFMG
T
IAR
S
M
P
Q
L
GL
L
V
I
L
V
-
LLP
L
QM
LSG
GST
P
R
ESMP
---
Q
M
VQD
IMLIM
PT
T
HF
VS
L
AQ
A
I
LY
R
G
A
G
F
E
IVW
PQ
F
L
T
L
M
A
IGGAFFTIA
L
LRFRKTI
fig|562.372.peg.4228
Escherichia coli 1212A (13-370/374)
KEL
R
SLL
G
D
-
--------KA
M
L
T
LIVF
S
F
TV
SV
YSSATVTPG
S
L
N
L
A
P
IAI
A
D
M
DQ
SQL
S
NRI
V
NS
F
Y
R
PWF
L
--P
P
E
M
I
T
A
DEMD
AG
LDAG
RY
T
F
AI
N
IPPNF
Q
R
--
D
VLA
G
R
Q
P
D
I
Q
V
N
VD
A
TRM
S
Q
A
F
T
GN
GYIQ
N
I
INGEV
N
SFVA
R
YR-
-
D
NSE
P
LV
SL
ETR
M
R
F
NPNLD
PA
WF
-
-
G
G
V
M
AII
NN
I
TM
LAI
VLT
G
SAL
I
RERE
H
GTV
EH
LLV
M
P
I
T
PF
EI
M
M
A
K
I
WSM
G
L
V
V
L
V
V
SG
L
SLV
LM
VK---G
V
L
GVP
IE
GS
IP
LF
M
L
GVA
L
S
LFAT
T
S
I
G
IFMG
T
IAR
S
M
P
Q
L
GL
L
V
I
L
V
-
LLP
L
QM
LSG
GST
P
R
ESMP
---
Q
M
VQD
IMLIM
PT
T
HF
VS
L
AQ
A
I
LY
R
G
A
G
F
E
IVW
PQ
F
L
T
L
M
A
IGGAFFTIA
L
LRFRKTI
fig|562.374.peg.5089
Escherichia coli 536A (13-370/374)
KEL
R
SLL
G
D
-
--------KA
M
L
T
LIVF
S
F
TV
SV
YSSATVTPG
S
L
N
L
A
P
IAI
A
D
M
DQ
SQL
S
NRI
V
NS
F
Y
R
PWF
L
--P
P
E
M
I
T
A
DEMD
AG
LDAG
RY
T
F
AI
N
IPPNF
Q
R
--
D
VLA
G
R
Q
P
D
I
Q
V
N
VD
A
TRM
S
Q
A
F
T
GN
GYIQ
N
I
INGEV
N
SFVA
R
YR-
-
D
NSE
P
LV
SL
ETR
M
R
F
NPNLD
PA
WF
-
-
G
G
V
M
AII
NN
I
TM
LAI
VLT
G
SAL
I
RERE
H
GTV
EH
LLV
M
P
I
T
PF
EI
M
M
A
K
I
WSM
G
L
V
V
L
V
V
SG
L
SLV
LM
VK---G
V
L
GVP
IE
GS
IP
LF
M
L
GVA
L
S
LFAT
T
S
I
G
IFMG
T
IAR
S
M
P
Q
L
GL
L
V
I
L
V
-
LLP
L
QM
LSG
GST
P
R
ESMP
---
Q
M
VQD
IMLIM
PT
T
HF
VS
L
AQ
A
I
LY
R
G
A
G
F
E
IVW
PQ
F
L
T
L
M
A
IGGAFFTIA
L
LRFRKTI
fig|83334.1.peg.4328
Escherichia coli O157:H7 (13-370/374)
KEL
R
SLL
G
D
-
--------KA
M
L
T
LIVF
S
F
TV
SV
YSSATVTPG
S
L
N
L
A
P
IAI
A
D
M
DQ
SQL
S
NRI
V
NS
F
Y
R
PWF
L
--P
P
E
M
I
T
A
DEMD
AG
LDAG
RY
T
F
AI
N
IPPNF
Q
R
--
D
VLA
G
R
Q
P
D
I
Q
V
N
VD
A
TRM
S
Q
A
F
T
GN
GYIQ
N
I
INGEV
N
SFVA
R
YR-
-
D
NSE
P
LV
SL
ETR
M
R
F
NPNLD
PA
WF
-
-
G
G
V
M
AII
NN
I
TM
LAI
VLT
G
SAL
I
RERE
H
GTV
EH
LLV
M
P
I
T
PF
EI
M
M
A
K
I
WSM
G
L
V
V
L
V
V
SG
L
SLV
LM
VK---G
V
L
GVP
IE
GS
IP
LF
M
L
GVA
L
S
LFAT
T
S
I
G
IFMG
T
IAR
S
M
P
Q
L
GL
L
V
I
L
V
-
LLP
L
QM
LSG
GST
P
R
ESMP
---
Q
M
VQD
IMLIM
PT
T
HF
VS
L
AQ
A
I
LY
R
G
A
G
F
E
IVW
PQ
F
L
T
L
M
A
IGGAFFTIA
L
LRFRKTI
fig|155864.8.peg.4308
Escherichia coli O157:H7 EDL933 (13-370/374)
KEL
R
SLL
G
D
-
--------KA
M
L
T
LIVF
S
F
TV
SV
YSSATVTPG
S
L
N
L
A
P
IAI
A
D
M
DQ
SQL
S
NRI
V
NS
F
Y
R
PWF
L
--P
P
E
M
I
T
A
DEMD
AG
LDAG
RY
T
F
AI
N
IPPNF
Q
R
--
D
VLA
G
R
Q
P
D
I
Q
V
N
VD
A
TRM
S
Q
A
F
T
GN
GYIQ
N
I
INGEV
N
SFVA
R
YR-
-
D
NSE
P
LV
SL
ETR
M
R
F
NPNLD
PA
WF
-
-
G
G
V
M
AII
NN
I
TM
LAI
VLT
G
SAL
I
RERE
H
GTV
EH
LLV
M
P
I
T
PF
EI
M
M
A
K
I
WSM
G
L
V
V
L
V
V
SG
L
SLV
LM
VK---G
V
L
GVP
IE
GS
IP
LF
M
L
GVA
L
S
LFAT
T
S
I
G
IFMG
T
IAR
S
M
P
Q
L
GL
L
V
I
L
V
-
LLP
L
QM
LSG
GST
P
R
ESMP
---
Q
M
VQD
IMLIM
PT
T
HF
VS
L
AQ
A
I
LY
R
G
A
G
F
E
IVW
PQ
F
L
T
L
M
A
IGGAFFTIA
L
LRFRKTI
fig|444454.5.peg.3437
Escherichia coli O157:H7 str. EC4024 (13-370/374)
KEL
R
SLL
G
D
-
--------KA
M
L
T
LIVF
S
F
TV
SV
YSSATVTPG
S
L
N
L
A
P
IAI
A
D
M
DQ
SQL
S
NRI
V
NS
F
Y
R
PWF
L
--P
P
E
M
I
T
A
DEMD
AG
LDAG
RY
T
F
AI
N
IPPNF
Q
R
--
D
VLA
G
R
Q
P
D
I
Q
V
N
VD
A
TRM
S
Q
A
F
T
GN
GYIQ
N
I
INGEV
N
SFVA
R
YR-
-
D
NSE
P
LV
SL
ETR
M
R
F
NPNLD
PA
WF
-
-
G
G
V
M
AII
NN
I
TM
LAI
VLT
G
SAL
I
RERE
H
GTV
EH
LLV
M
P
I
T
PF
EI
M
M
A
K
I
WSM
G
L
V
V
L
V
V
SG
L
SLV
LM
VK---G
V
L
GVP
IE
GS
IP
LF
M
L
GVA
L
S
LFAT
T
S
I
G
IFMG
T
IAR
S
M
P
Q
L
GL
L
V
I
L
V
-
LLP
L
QM
LSG
GST
P
R
ESMP
---
Q
M
VQD
IMLIM
PT
T
HF
VS
L
AQ
A
I
LY
R
G
A
G
F
E
IVW
PQ
F
L
T
L
M
A
IGGAFFTIA
L
LRFRKTI
fig|444449.5.peg.2892
Escherichia coli O157:H7 str. EC4042 (13-370/374)
KEL
R
SLL
G
D
-
--------KA
M
L
T
LIVF
S
F
TV
SV
YSSATVTPG
S
L
N
L
A
P
IAI
A
D
M
DQ
SQL
S
NRI
V
NS
F
Y
R
PWF
L
--P
P
E
M
I
T
A
DEMD
AG
LDAG
RY
T
F
AI
N
IPPNF
Q
R
--
D
VLA
G
R
Q
P
D
I
Q
V
N
VD
A
TRM
S
Q
A
F
T
GN
GYIQ
N
I
INGEV
N
SFVA
R
YR-
-
D
NSE
P
LV
SL
ETR
M
R
F
NPNLD
PA
WF
-
-
G
G
V
M
AII
NN
I
TM
LAI
VLT
G
SAL
I
RERE
H
GTV
EH
LLV
M
P
I
T
PF
EI
M
M
A
K
I
WSM
G
L
V
V
L
V
V
SG
L
SLV
LM
VK---G
V
L
GVP
IE
GS
IP
LF
M
L
GVA
L
S
LFAT
T
S
I
G
IFMG
T
IAR
S
M
P
Q
L
GL
L
V
I
L
V
-
LLP
L
QM
LSG
GST
P
R
ESMP
---
Q
M
VQD
IMLIM
PT
T
HF
VS
L
AQ
A
I
LY
R
G
A
G
F
E
IVW
PQ
F
L
T
L
M
A
IGGAFFTIA
L
LRFRKTI
fig|444448.5.peg.1644
Escherichia coli O157:H7 str. EC4045 (13-370/374)
KEL
R
SLL
G
D
-
--------KA
M
L
T
LIVF
S
F
TV
SV
YSSATVTPG
S
L
N
L
A
P
IAI
A
D
M
DQ
SQL
S
NRI
V
NS
F
Y
R
PWF
L
--P
P
E
M
I
T
A
DEMD
AG
LDAG
RY
T
F
AI
N
IPPNF
Q
R
--
D
VLA
G
R
Q
P
D
I
Q
V
N
VD
A
TRM
S
Q
A
F
T
GN
GYIQ
N
I
INGEV
N
SFVA
R
YR-
-
D
NSE
P
LV
SL
ETR
M
R
F
NPNLD
PA
WF
-
-
G
G
V
M
AII
NN
I
TM
LAI
VLT
G
SAL
I
RERE
H
GTV
EH
LLV
M
P
I
T
PF
EI
M
M
A
K
I
WSM
G
L
V
V
L
V
V
SG
L
SLV
LM
VK---G
V
L
GVP
IE
GS
IP
LF
M
L
GVA
L
S
LFAT
T
S
I
G
IFMG
T
IAR
S
M
P
Q
L
GL
L
V
I
L
V
-
LLP
L
QM
LSG
GST
P
R
ESMP
---
Q
M
VQD
IMLIM
PT
T
HF
VS
L
AQ
A
I
LY
R
G
A
G
F
E
IVW
PQ
F
L
T
L
M
A
IGGAFFTIA
L
LRFRKTI
fig|444453.5.peg.1176
Escherichia coli O157:H7 str. EC4076 (13-370/374)
KEL
R
SLL
G
D
-
--------KA
M
L
T
LIVF
S
F
TV
SV
YSSATVTPG
S
L
N
L
A
P
IAI
A
D
M
DQ
SQL
S
NRI
V
NS
F
Y
R
PWF
L
--P
P
E
M
I
T
A
DEMD
AG
LDAG
RY
T
F
AI
N
IPPNF
Q
R
--
D
VLA
G
R
Q
P
D
I
Q
V
N
VD
A
TRM
S
Q
A
F
T
GN
GYIQ
N
I
INGEV
N
SFVA
R
YR-
-
D
NSE
P
LV
SL
ETR
M
R
F
NPNLD
PA
WF
-
-
G
G
V
M
AII
NN
I
TM
LAI
VLT
G
SAL
I
RERE
H
GTV
EH
LLV
M
P
I
T
PF
EI
M
M
A
K
I
WSM
G
L
V
V
L
V
V
SG
L
SLV
LM
VK---G
V
L
GVP
IE
GS
IP
LF
M
L
GVA
L
S
LFAT
T
S
I
G
IFMG
T
IAR
S
M
P
Q
L
GL
L
V
I
L
V
-
LLP
L
QM
LSG
GST
P
R
ESMP
---
Q
M
VQD
IMLIM
PT
T
HF
VS
L
AQ
A
I
LY
R
G
A
G
F
E
IVW
PQ
F
L
T
L
M
A
IGGAFFTIA
L
LRFRKTI
fig|444452.5.peg.166
Escherichia coli O157:H7 str. EC4113 (13-370/374)
KEL
R
SLL
G
D
-
--------KA
M
L
T
LIVF
S
F
TV
SV
YSSATVTPG
S
L
N
L
A
P
IAI
A
D
M
DQ
SQL
S
NRI
V
NS
F
Y
R
PWF
L
--P
P
E
M
I
T
A
DEMD
AG
LDAG
RY
T
F
AI
N
IPPNF
Q
R
--
D
VLA
G
R
Q
P
D
I
Q
V
N
VD
A
TRM
S
Q
A
F
T
GN
GYIQ
N
I
INGEV
N
SFVA
R
YR-
-
D
NSE
P
LV
SL
ETR
M
R
F
NPNLD
PA
WF
-
-
G
G
V
M
AII
NN
I
TM
LAI
VLT
G
SAL
I
RERE
H
GTV
EH
LLV
M
P
I
T
PF
EI
M
M
A
K
I
WSM
G
L
V
V
L
V
V
SG
L
SLV
LM
VK---G
V
L
GVP
IE
GS
IP
LF
M
L
GVA
L
S
LFAT
T
S
I
G
IFMG
T
IAR
S
M
P
Q
L
GL
L
V
I
L
V
-
LLP
L
QM
LSG
GST
P
R
ESMP
---
Q
M
VQD
IMLIM
PT
T
HF
VS
L
AQ
A
I
LY
R
G
A
G
F
E
IVW
PQ
F
L
T
L
M
A
IGGAFFTIA
L
LRFRKTI
fig|444450.8.peg.4726
Escherichia coli O157:H7 str. EC4115 (13-370/374)
KEL
R
SLL
G
D
-
--------KA
M
L
T
LIVF
S
F
TV
SV
YSSATVTPG
S
L
N
L
A
P
IAI
A
D
M
DQ
SQL
S
NRI
V
NS
F
Y
R
PWF
L
--P
P
E
M
I
T
A
DEMD
AG
LDAG
RY
T
F
AI
N
IPPNF
Q
R
--
D
VLA
G
R
Q
P
D
I
Q
V
N
VD
A
TRM
S
Q
A
F
T
GN
GYIQ
N
I
INGEV
N
SFVA
R
YR-
-
D
NSE
P
LV
SL
ETR
M
R
F
NPNLD
PA
WF
-
-
G
G
V
M
AII
NN
I
TM
LAI
VLT
G
SAL
I
RERE
H
GTV
EH
LLV
M
P
I
T
PF
EI
M
M
A
K
I
WSM
G
L
V
V
L
V
V
SG
L
SLV
LM
VK---G
V
L
GVP
IE
GS
IP
LF
M
L
GVA
L
S
LFAT
T
S
I
G
IFMG
T
IAR
S
M
P
Q
L
GL
L
V
I
L
V
-
LLP
L
QM
LSG
GST
P
R
ESMP
---
Q
M
VQD
IMLIM
PT
T
HF
VS
L
AQ
A
I
LY
R
G
A
G
F
E
IVW
PQ
F
L
T
L
M
A
IGGAFFTIA
L
LRFRKTI
fig|444451.5.peg.340
Escherichia coli O157:H7 str. EC4196 (13-370/374)
KEL
R
SLL
G
D
-
--------KA
M
L
T
LIVF
S
F
TV
SV
YSSATVTPG
S
L
N
L
A
P
IAI
A
D
M
DQ
SQL
S
NRI
V
NS
F
Y
R
PWF
L
--P
P
E
M
I
T
A
DEMD
AG
LDAG
RY
T
F
AI
N
IPPNF
Q
R
--
D
VLA
G
R
Q
P
D
I
Q
V
N
VD
A
TRM
S
Q
A
F
T
GN
GYIQ
N
I
INGEV
N
SFVA
R
YR-
-
D
NSE
P
LV
SL
ETR
M
R
F
NPNLD
PA
WF
-
-
G
G
V
M
AII
NN
I
TM
LAI
VLT
G
SAL
I
RERE
H
GTV
EH
LLV
M
P
I
T
PF
EI
M
M
A
K
I
WSM
G
L
V
V
L
V
V
SG
L
SLV
LM
VK---G
V
L
GVP
IE
GS
IP
LF
M
L
GVA
L
S
LFAT
T
S
I
G
IFMG
T
IAR
S
M
P
Q
L
GL
L
V
I
L
V
-
LLP
L
QM
LSG
GST
P
R
ESMP
---
Q
M
VQD
IMLIM
PT
T
HF
VS
L
AQ
A
I
LY
R
G
A
G
F
E
IVW
PQ
F
L
T
L
M
A
IGGAFFTIA
L
LRFRKTI
fig|444447.5.peg.1807
Escherichia coli O157:H7 str. EC4206 (13-370/374)
KEL
R
SLL
G
D
-
--------KA
M
L
T
LIVF
S
F
TV
SV
YSSATVTPG
S
L
N
L
A
P
IAI
A
D
M
DQ
SQL
S
NRI
V
NS
F
Y
R
PWF
L
--P
P
E
M
I
T
A
DEMD
AG
LDAG
RY
T
F
AI
N
IPPNF
Q
R
--
D
VLA
G
R
Q
P
D
I
Q
V
N
VD
A
TRM
S
Q
A
F
T
GN
GYIQ
N
I
INGEV
N
SFVA
R
YR-
-
D
NSE
P
LV
SL
ETR
M
R
F
NPNLD
PA
WF
-
-
G
G
V
M
AII
NN
I
TM
LAI
VLT
G
SAL
I
RERE
H
GTV
EH
LLV
M
P
I
T
PF
EI
M
M
A
K
I
WSM
G
L
V
V
L
V
V
SG
L
SLV
LM
VK---G
V
L
GVP
IE
GS
IP
LF
M
L
GVA
L
S
LFAT
T
S
I
G
IFMG
T
IAR
S
M
P
Q
L
GL
L
V
I
L
V
-
LLP
L
QM
LSG
GST
P
R
ESMP
---
Q
M
VQD
IMLIM
PT
T
HF
VS
L
AQ
A
I
LY
R
G
A
G
F
E
IVW
PQ
F
L
T
L
M
A
IGGAFFTIA
L
LRFRKTI
fig|478004.5.peg.202
Escherichia coli O157:H7 str. EC4401 (13-370/374)
KEL
R
SLL
G
D
-
--------KA
M
L
T
LIVF
S
F
TV
SV
YSSATVTPG
S
L
N
L
A
P
IAI
A
D
M
DQ
SQL
S
NRI
V
NS
F
Y
R
PWF
L
--P
P
E
M
I
T
A
DEMD
AG
LDAG
RY
T
F
AI
N
IPPNF
Q
R
--
D
VLA
G
R
Q
P
D
I
Q
V
N
VD
A
TRM
S
Q
A
F
T
GN
GYIQ
N
I
INGEV
N
SFVA
R
YR-
-
D
NSE
P
LV
SL
ETR
M
R
F
NPNLD
PA
WF
-
-
G
G
V
M
AII
NN
I
TM
LAI
VLT
G
SAL
I
RERE
H
GTV
EH
LLV
M
P
I
T
PF
EI
M
M
A
K
I
WSM
G
L
V
V
L
V
V
SG
L
SLV
LM
VK---G
V
L
GVP
IE
GS
IP
LF
M
L
GVA
L
S
LFAT
T
S
I
G
IFMG
T
IAR
S
M
P
Q
L
GL
L
V
I
L
V
-
LLP
L
QM
LSG
GST
P
R
ESMP
---
Q
M
VQD
IMLIM
PT
T
HF
VS
L
AQ
A
I
LY
R
G
A
G
F
E
IVW
PQ
F
L
T
L
M
A
IGGAFFTIA
L
LRFRKTI
fig|478006.5.peg.167
Escherichia coli O157:H7 str. EC4501 (13-370/374)
KEL
R
SLL
G
D
-
--------KA
M
L
T
LIVF
S
F
TV
SV
YSSATVTPG
S
L
N
L
A
P
IAI
A
D
M
DQ
SQL
S
NRI
V
NS
F
Y
R
PWF
L
--P
P
E
M
I
T
A
DEMD
AG
LDAG
RY
T
F
AI
N
IPPNF
Q
R
--
D
VLA
G
R
Q
P
D
I
Q
V
N
VD
A
TRM
S
Q
A
F
T
GN
GYIQ
N
I
INGEV
N
SFVA
R
YR-
-
D
NSE
P
LV
SL
ETR
M
R
F
NPNLD
PA
WF
-
-
G
G
V
M
AII
NN
I
TM
LAI
VLT
G
SAL
I
RERE
H
GTV
EH
LLV
M
P
I
T
PF
EI
M
M
A
K
I
WSM
G
L
V
V
L
V
V
SG
L
SLV
LM
VK---G
V
L
GVP
IE
GS
IP
LF
M
L
GVA
L
S
LFAT
T
S
I
G
IFMG
T
IAR
S
M
P
Q
L
GL
L
V
I
L
V
-
LLP
L
QM
LSG
GST
P
R
ESMP
---
Q
M
VQD
IMLIM
PT
T
HF
VS
L
AQ
A
I
LY
R
G
A
G
F
E
IVW
PQ
F
L
T
L
M
A
IGGAFFTIA
L
LRFRKTI
fig|478007.5.peg.175
Escherichia coli O157:H7 str. EC508 (13-370/374)
KEL
R
SLL
G
D
-
--------KA
M
L
T
LIVF
S
F
TV
SV
YSSATVTPG
S
L
N
L
A
P
IAI
A
D
M
DQ
SQL
S
NRI
V
NS
F
Y
R
PWF
L
--P
P
E
M
I
T
A
DEMD
AG
LDAG
RY
T
F
AI
N
IPPNF
Q
R
--
D
VLA
G
R
Q
P
D
I
Q
V
N
VD
A
TRM
S
Q
A
F
T
GN
GYIQ
N
I
INGEV
N
SFVA
R
YR-
-
D
NSE
P
LV
SL
ETR
M
R
F
NPNLD
PA
WF
-
-
G
G
V
M
AII
NN
I
TM
LAI
VLT
G
SAL
I
RERE
H
GTV
EH
LLV
M
P
I
T
PF
EI
M
M
A
K
I
WSM
G
L
V
V
L
V
V
SG
L
SLV
LM
VK---G
V
L
GVP
IE
GS
IP
LF
M
L
GVA
L
S
LFAT
T
S
I
G
IFMG
T
IAR
S
M
P
Q
L
GL
L
V
I
L
V
-
LLP
L
QM
LSG
GST
P
R
ESMP
---
Q
M
VQD
IMLIM
PT
T
HF
VS
L
AQ
A
I
LY
R
G
A
G
F
E
IVW
PQ
F
L
T
L
M
A
IGGAFFTIA
L
LRFRKTI
fig|478008.5.peg.697
Escherichia coli O157:H7 str. EC869 (13-370/374)
KEL
R
SLL
G
D
-
--------KA
M
L
T
LIVF
S
F
TV
SV
YSSATVTPG
S
L
N
L
A
P
IAI
A
D
M
DQ
SQL
S
NRI
V
NS
F
Y
R
PWF
L
--P
P
E
M
I
T
A
DEMD
AG
LDAG
RY
T
F
AI
N
IPPNF
Q
R
--
D
VLA
G
R
Q
P
D
I
Q
V
N
VD
A
TRM
S
Q
A
F
T
GN
GYIQ
N
I
INGEV
N
SFVA
R
YR-
-
D
NSE
P
LV
SL
ETR
M
R
F
NPNLD
PA
WF
-
-
G
G
V
M
AII
NN
I
TM
LAI
VLT
G
SAL
I
RERE
H
GTV
EH
LLV
M
P
I
T
PF
EI
M
M
A
K
I
WSM
G
L
V
V
L
V
V
SG
L
SLV
LM
VK---G
V
L
GVP
IE
GS
IP
LF
M
L
GVA
L
S
LFAT
T
S
I
G
IFMG
T
IAR
S
M
P
Q
L
GL
L
V
I
L
V
-
LLP
L
QM
LSG
GST
P
R
ESMP
---
Q
M
VQD
IMLIM
PT
T
HF
VS
L
AQ
A
I
LY
R
G
A
G
F
E
IVW
PQ
F
L
T
L
M
A
IGGAFFTIA
L
LRFRKTI
fig|637388.3.peg.1888
Escherichia coli O157:H7 str. FRIK2000 (13-370/374)
KEL
R
SLL
G
D
-
--------KA
M
L
T
LIVF
S
F
TV
SV
YSSATVTPG
S
L
N
L
A
P
IAI
A
D
M
DQ
SQL
S
NRI
V
NS
F
Y
R
PWF
L
--P
P
E
M
I
T
A
DEMD
AG
LDAG
RY
T
F
AI
N
IPPNF
Q
R
--
D
VLA
G
R
Q
P
D
I
Q
V
N
VD
A
TRM
S
Q
A
F
T
GN
GYIQ
N
I
INGEV
N
SFVA
R
YR-
-
D
NSE
P
LV
SL
ETR
M
R
F
NPNLD
PA
WF
-
-
G
G
V
M
AII
NN
I
TM
LAI
VLT
G
SAL
I
RERE
H
GTV
EH
LLV
M
P
I
T
PF
EI
M
M
A
K
I
WSM
G
L
V
V
L
V
V
SG
L
SLV
LM
VK---G
V
L
GVP
IE
GS
IP
LF
M
L
GVA
L
S
LFAT
T
S
I
G
IFMG
T
IAR
S
M
P
Q
L
GL
L
V
I
L
V
-
LLP
L
QM
LSG
GST
P
R
ESMP
---
Q
M
VQD
IMLIM
PT
T
HF
VS
L
AQ
A
I
LY
R
G
A
G
F
E
IVW
PQ
F
L
T
L
M
A
IGGAFFTIA
L
LRFRKTI
fig|570506.3.peg.132
Escherichia coli O157:H7 str. FRIK966 (13-370/374)
KEL
R
SLL
G
D
-
--------KA
M
L
T
LIVF
S
F
TV
SV
YSSATVTPG
S
L
N
L
A
P
IAI
A
D
M
DQ
SQL
S
NRI
V
NS
F
Y
R
PWF
L
--P
P
E
M
I
T
A
DEMD
AG
LDAG
RY
T
F
AI
N
IPPNF
Q
R
--
D
VLA
G
R
Q
P
D
I
Q
V
N
VD
A
TRM
S
Q
A
F
T
GN
GYIQ
N
I
INGEV
N
SFVA
R
YR-
-
D
NSE
P
LV
SL
ETR
M
R
F
NPNLD
PA
WF
-
-
G
G
V
M
AII
NN
I
TM
LAI
VLT
G
SAL
I
RERE
H
GTV
EH
LLV
M
P
I
T
PF
EI
M
M
A
K
I
WSM
G
L
V
V
L
V
V
SG
L
SLV
LM
VK---G
V
L
GVP
IE
GS
IP
LF
M
L
GVA
L
S
LFAT
T
S
I
G
IFMG
T
IAR
S
M
P
Q
L
GL
L
V
I
L
V
-
LLP
L
QM
LSG
GST
P
R
ESMP
---
Q
M
VQD
IMLIM
PT
T
HF
VS
L
AQ
A
I
LY
R
G
A
G
F
E
IVW
PQ
F
L
T
L
M
A
IGGAFFTIA
L
LRFRKTI
fig|386585.9.peg.4550
Escherichia coli O157:H7 str. Sakai (13-370/374)
KEL
R
SLL
G
D
-
--------KA
M
L
T
LIVF
S
F
TV
SV
YSSATVTPG
S
L
N
L
A
P
IAI
A
D
M
DQ
SQL
S
NRI
V
NS
F
Y
R
PWF
L
--P
P
E
M
I
T
A
DEMD
AG
LDAG
RY
T
F
AI
N
IPPNF
Q
R
--
D
VLA
G
R
Q
P
D
I
Q
V
N
VD
A
TRM
S
Q
A
F
T
GN
GYIQ
N
I
INGEV
N
SFVA
R
YR-
-
D
NSE
P
LV
SL
ETR
M
R
F
NPNLD
PA
WF
-
-
G
G
V
M
AII
NN
I
TM
LAI
VLT
G
SAL
I
RERE
H
GTV
EH
LLV
M
P
I
T
PF
EI
M
M
A
K
I
WSM
G
L
V
V
L
V
V
SG
L
SLV
LM
VK---G
V
L
GVP
IE
GS
IP
LF
M
L
GVA
L
S
LFAT
T
S
I
G
IFMG
T
IAR
S
M
P
Q
L
GL
L
V
I
L
V
-
LLP
L
QM
LSG
GST
P
R
ESMP
---
Q
M
VQD
IMLIM
PT
T
HF
VS
L
AQ
A
I
LY
R
G
A
G
F
E
IVW
PQ
F
L
T
L
M
A
IGGAFFTIA
L
LRFRKTI
fig|544404.4.peg.4536
Escherichia coli O157:H7 str. TW14359 (13-370/374)
KEL
R
SLL
G
D
-
--------KA
M
L
T
LIVF
S
F
TV
SV
YSSATVTPG
S
L
N
L
A
P
IAI
A
D
M
DQ
SQL
S
NRI
V
NS
F
Y
R
PWF
L
--P
P
E
M
I
T
A
DEMD
AG
LDAG
RY
T
F
AI
N
IPPNF
Q
R
--
D
VLA
G
R
Q
P
D
I
Q
V
N
VD
A
TRM
S
Q
A
F
T
GN
GYIQ
N
I
INGEV
N
SFVA
R
YR-
-
D
NSE
P
LV
SL
ETR
M
R
F
NPNLD
PA
WF
-
-
G
G
V
M
AII
NN
I
TM
LAI
VLT
G
SAL
I
RERE
H
GTV
EH
LLV
M
P
I
T
PF
EI
M
M
A
K
I
WSM
G
L
V
V
L
V
V
SG
L
SLV
LM
VK---G
V
L
GVP
IE
GS
IP
LF
M
L
GVA
L
S
LFAT
T
S
I
G
IFMG
T
IAR
S
M
P
Q
L
GL
L
V
I
L
V
-
LLP
L
QM
LSG
GST
P
R
ESMP
---
Q
M
VQD
IMLIM
PT
T
HF
VS
L
AQ
A
I
LY
R
G
A
G
F
E
IVW
PQ
F
L
T
L
M
A
IGGAFFTIA
L
LRFRKTI
fig|502346.5.peg.2293
Escherichia coli O157:H7 str. TW14588 (13-370/374)
KEL
R
SLL
G
D
-
--------KA
M
L
T
LIVF
S
F
TV
SV
YSSATVTPG
S
L
N
L
A
P
IAI
A
D
M
DQ
SQL
S
NRI
V
NS
F
Y
R
PWF
L
--P
P
E
M
I
T
A
DEMD
AG
LDAG
RY
T
F
AI
N
IPPNF
Q
R
--
D
VLA
G
R
Q
P
D
I
Q
V
N
VD
A
TRM
S
Q
A
F
T
GN
GYIQ
N
I
INGEV
N
SFVA
R
YR-
-
D
NSE
P
LV
SL
ETR
M
R
F
NPNLD
PA
WF
-
-
G
G
V
M
AII
NN
I
TM
LAI
VLT
G
SAL
I
RERE
H
GTV
EH
LLV
M
P
I
T
PF
EI
M
M
A
K
I
WSM
G
L
V
V
L
V
V
SG
L
SLV
LM
VK---G
V
L
GVP
IE
GS
IP
LF
M
L
GVA
L
S
LFAT
T
S
I
G
IFMG
T
IAR
S
M
P
Q
L
GL
L
V
I
L
V
-
LLP
L
QM
LSG
GST
P
R
ESMP
---
Q
M
VQD
IMLIM
PT
T
HF
VS
L
AQ
A
I
LY
R
G
A
G
F
E
IVW
PQ
F
L
T
L
M
A
IGGAFFTIA
L
LRFRKTI
fig|701177.3.peg.4229
Escherichia coli O55:H7 str. CB9615 (13-370/374)
KEL
R
SLL
G
D
-
--------KA
M
L
T
LIVF
S
F
TV
SV
YSSATVTPG
S
L
N
L
A
P
IAI
A
D
M
DQ
SQL
S
NRI
V
NS
F
Y
R
PWF
L
--P
P
E
M
I
T
A
DEMD
AG
LDAG
RY
T
F
AI
N
IPPNF
Q
R
--
D
VLA
G
R
Q
P
D
I
Q
V
N
VD
A
TRM
S
Q
A
F
T
GN
GYIQ
N
I
INGEV
N
SFVA
R
YR-
-
D
NSE
P
LV
SL
ETR
M
R
F
NPNLD
PA
WF
-
-
G
G
V
M
AII
NN
I
TM
LAI
VLT
G
SAL
I
RERE
H
GTV
EH
LLV
M
P
I
T
PF
EI
M
M
A
K
I
WSM
G
L
V
V
L
V
V
SG
L
SLV
LM
VK---G
V
L
GVP
IE
GS
IP
LF
M
L
GVA
L
S
LFAT
T
S
I
G
IFMG
T
IAR
S
M
P
Q
L
GL
L
V
I
L
V
-
LLP
L
QM
LSG
GST
P
R
ESMP
---
Q
M
VQD
IMLIM
PT
T
HF
VS
L
AQ
A
I
LY
R
G
A
G
F
E
IVW
PQ
F
L
T
L
M
A
IGGAFFTIA
L
LRFRKTI
fig|199310.1.peg.4190
Escherichia coli CFT073 (41-398/402)
KEL
R
SLL
G
D
-
--------KA
M
L
T
LIVF
S
F
TV
SV
YSSATVTPG
S
L
N
L
A
P
IAI
A
D
M
DQ
SQL
S
NRI
V
NS
F
Y
R
PWF
L
--P
P
E
M
I
T
A
DEMD
AG
LDAG
RY
T
F
AI
N
IPPNF
Q
R
--
D
VLA
G
R
Q
P
D
I
Q
V
N
VD
A
TRM
S
Q
A
F
T
GN
GYIQ
N
I
INGEV
N
SFVA
R
YR-
-
D
NSE
P
LV
SL
ETR
M
R
F
NPNLD
PA
WF
-
-
G
G
V
M
AII
NN
I
TM
LAI
VLT
G
SAL
I
RERE
H
GTV
EH
LLV
M
P
I
T
PF
EI
M
M
A
K
V
WSM
G
L
V
V
L
V
V
SG
L
SLV
LM
VK---G
V
L
GVP
IE
GS
IP
LF
M
L
GVA
L
S
LFAT
T
S
I
G
IFMG
T
IAR
S
M
P
Q
L
GL
L
V
I
L
V
-
LLP
L
QM
LSG
GST
P
R
ESMP
---
Q
M
VQD
IMLTM
PT
T
HF
VS
L
AQ
A
I
LY
R
G
A
G
F
E
IVW
PQ
F
L
T
L
M
A
IGGAFFTIA
L
LRFRKTI
fig|216593.1.peg.4207
Escherichia coli E2348/69 (41-398/402)
KEL
R
SLL
G
D
-
--------KA
M
L
T
LIVF
S
F
TV
SV
YSSATVTPG
S
L
N
L
A
P
IAI
A
D
M
DQ
SQL
S
NRI
V
NS
F
Y
R
PWF
L
--P
P
E
M
I
T
A
DEMD
AG
LDAG
RY
T
F
AI
N
IPPNF
Q
R
--
D
VLA
G
R
Q
P
D
I
Q
V
N
VD
A
TRM
S
Q
A
F
T
GN
GYIQ
N
I
INGEV
N
SFVA
R
YR-
-
D
NSE
P
LV
SL
ETR
M
R
F
NPNLD
PA
WF
-
-
G
G
V
M
AII
NN
I
TM
LAI
VLT
G
SAL
I
RERE
H
GTV
EH
LLV
M
P
I
T
PF
EI
M
M
A
K
V
WSM
G
L
V
V
L
V
V
SG
L
SLV
LM
VK---G
V
L
GVP
IE
GS
IP
LF
M
L
GVA
L
S
LFAT
T
S
I
G
IFMG
T
IAR
S
M
P
Q
L
GL
L
V
I
L
V
-
LLP
L
QM
LSG
GST
P
R
ESMP
---
Q
M
VQD
IMLTM
PT
T
HF
VS
L
AQ
A
I
LY
R
G
A
G
F
E
IVW
PQ
F
L
T
L
M
A
IGGAFFTIA
L
LRFRKTI
fig|749537.3.peg.611
Escherichia coli MS 115-1 (13-370/374)
KEL
R
SLL
G
D
-
--------KA
M
L
T
LIVF
S
F
TV
SV
YSSATVTPG
S
L
N
L
A
P
IAI
A
D
M
DQ
SQL
S
NRI
V
NS
F
Y
R
PWF
L
--P
P
E
M
I
T
A
DEMD
AG
LDAG
RY
T
F
AI
N
IPPNF
Q
R
--
D
VLA
G
R
Q
P
D
I
Q
V
N
VD
A
TRM
S
Q
A
F
T
GN
GYIQ
N
I
INGEV
N
SFVA
R
YR-
-
D
NSE
P
LV
SL
ETR
M
R
F
NPNLD
PA
WF
-
-
G
G
V
M
AII
NN
I
TM
LAI
VLT
G
SAL
I
RERE
H
GTV
EH
LLV
M
P
I
T
PF
EI
M
M
A
K
I
WSM
G
L
V
V
L
V
V
SG
L
SLV
LM
VK---G
V
L
GVP
IE
GS
IP
LF
M
L
GVA
L
S
LFAT
T
S
I
G
IFMG
T
IAR
S
M
P
Q
L
GL
L
V
I
L
V
-
LLP
L
QM
LSG
GST
P
R
ESMP
---
Q
M
VQD
IMLTM
PT
T
HF
VS
L
AQ
A
I
LY
R
G
A
G
F
E
IVW
PQ
F
L
T
L
M
A
IGGAFFTIA
L
LRFRK
R
I
fig|216592.3.peg.3913
Escherichia coli 042 (13-370/374)
KEL
R
SLL
G
D
-
--------KA
M
L
T
LIVF
S
F
TV
SV
YSSATVTPG
S
L
N
L
A
P
IAI
A
D
M
DQ
SQL
S
NRI
V
NS
F
Y
R
PWF
L
--P
P
E
M
I
T
A
DEMD
AG
LDAG
RY
T
F
AI
N
IPPNF
Q
R
--
D
VLA
G
R
Q
P
D
I
Q
V
N
VD
A
TRM
S
Q
A
F
T
GN
GYIQ
N
I
INGEV
N
SFVA
R
YR-
-
D
NSE
P
LV
SL
ETR
M
R
F
NPNLD
PA
WF
-
-
G
G
V
M
AII
NN
I
TM
LAI
VLT
G
SAL
I
RERE
H
GTV
EH
LLV
M
P
I
T
PF
EI
M
M
A
K
I
WSM
G
L
V
V
L
V
V
SG
L
SLV
LM
VK---G
V
L
GVP
IE
GS
IP
LF
M
L
GVA
L
S
LFAT
T
S
I
G
IFMG
T
IAR
S
M
P
Q
L
GL
L
V
I
L
V
-
LLP
L
QM
LSG
GST
P
R
ESMP
---
Q
M
VQD
IMLTM
PT
T
HF
VS
L
AQ
A
I
LY
R
G
A
G
F
E
IVW
SQ
F
L
T
L
M
A
IGGAFFTIA
L
LRFRKTI
fig|405955.13.peg.3921
Escherichia coli APEC O1 (13-370/374)
KEL
R
SLL
G
D
-
--------KA
M
L
T
LIVF
S
F
TV
SV
YSSATVTPG
S
L
N
F
A
P
IAI
A
D
M
DQ
SQL
S
NRI
V
NS
F
Y
R
PWF
L
--P
P
E
M
I
T
A
DEMD
AG
LDAG
RY
T
F
AI
N
IPPNF
Q
R
--
D
VLA
G
R
Q
P
D
I
Q
V
N
VD
A
TRM
S
Q
A
F
T
GN
GYIQ
N
I
INGEV
N
SFVA
R
YR-
-
D
NSE
P
LV
SL
ETR
M
R
F
NPNLD
PA
WF
-
-
G
G
V
M
AII
NN
I
TM
LAI
VLT
G
SAL
I
RERE
H
GTV
EH
LLV
M
P
I
T
PF
EI
M
M
A
K
V
WSM
G
L
V
V
L
V
V
SG
L
SLV
LM
VK---G
V
L
GVP
IE
GS
IP
LF
M
L
GVA
L
S
LFAT
T
S
I
G
IFMG
T
IAR
S
M
P
Q
L
GL
L
V
I
L
V
-
LLP
L
QM
LSG
GST
P
R
ESMP
---
Q
M
VQD
IMLTM
PT
T
HF
VS
L
AQ
A
I
LY
R
G
A
G
F
E
IVW
PQ
F
L
T
L
M
A
IGGAFFTIA
L
LRFRKTI
fig|525281.3.peg.2930
Escherichia coli 83972 (13-370/374)
KEL
R
SLL
G
D
-
--------KA
M
L
T
LIVF
S
F
TV
SV
YSSATVTPG
S
L
N
L
A
P
IAI
A
D
M
DQ
SQL
S
NRI
V
NS
F
Y
R
PWF
L
--P
P
E
M
I
T
A
DEMD
AG
LDAG
RY
T
F
AI
N
IPPNF
Q
R
--
D
VLA
G
R
Q
P
D
I
Q
V
N
VD
A
TRM
S
Q
A
F
T
GN
GYIQ
N
I
INGEV
N
SFVA
R
YR-
-
D
NSE
P
LV
SL
ETR
M
R
F
NPNLD
PA
WF
-
-
G
G
V
M
AII
NN
I
TM
LAI
VLT
G
SAL
I
RERE
H
GTV
EH
LLV
M
P
I
T
PF
EI
M
M
A
K
V
WSM
G
L
V
V
L
V
V
SG
L
SLV
LM
VK---G
V
L
GVP
IE
GS
IP
LF
M
L
GVA
L
S
LFAT
T
S
I
G
IFMG
T
IAR
S
M
P
Q
L
GL
L
V
I
L
V
-
LLP
L
QM
LSG
GST
P
R
ESMP
---
Q
M
VQD
IMLTM
PT
T
HF
VS
L
AQ
A
I
LY
R
G
A
G
F
E
IVW
PQ
F
L
T
L
M
A
IGGAFFTIA
L
LRFRKTI
fig|655817.3.peg.4087
Escherichia coli ABU 83972 (13-370/374)
KEL
R
SLL
G
D
-
--------KA
M
L
T
LIVF
S
F
TV
SV
YSSATVTPG
S
L
N
L
A
P
IAI
A
D
M
DQ
SQL
S
NRI
V
NS
F
Y
R
PWF
L
--P
P
E
M
I
T
A
DEMD
AG
LDAG
RY
T
F
AI
N
IPPNF
Q
R
--
D
VLA
G
R
Q
P
D
I
Q
V
N
VD
A
TRM
S
Q
A
F
T
GN
GYIQ
N
I
INGEV
N
SFVA
R
YR-
-
D
NSE
P
LV
SL
ETR
M
R
F
NPNLD
PA
WF
-
-
G
G
V
M
AII
NN
I
TM
LAI
VLT
G
SAL
I
RERE
H
GTV
EH
LLV
M
P
I
T
PF
EI
M
M
A
K
V
WSM
G
L
V
V
L
V
V
SG
L
SLV
LM
VK---G
V
L
GVP
IE
GS
IP
LF
M
L
GVA
L
S
LFAT
T
S
I
G
IFMG
T
IAR
S
M
P
Q
L
GL
L
V
I
L
V
-
LLP
L
QM
LSG
GST
P
R
ESMP
---
Q
M
VQD
IMLTM
PT
T
HF
VS
L
AQ
A
I
LY
R
G
A
G
F
E
IVW
PQ
F
L
T
L
M
A
IGGAFFTIA
L
LRFRKTI
fig|550672.3.peg.3529
Escherichia coli B088 (13-370/374)
KEL
R
SLL
G
D
-
--------KA
M
L
T
LIVF
S
F
TV
SV
YSSATVTPG
S
L
N
L
A
P
IAI
A
D
M
DQ
SQL
S
NRI
V
NS
F
Y
R
PWF
L
--P
P
E
M
I
T
A
DEMD
AG
LDAG
RY
T
F
AI
N
IPPNF
Q
R
--
D
VLA
G
R
Q
P
D
I
Q
V
N
VD
A
TRM
S
Q
A
F
T
GN
GYIQ
N
I
INGEV
N
SFVA
R
YR-
-
D
NSE
P
LV
SL
ETR
M
R
F
NPNLD
PA
WF
-
-
G
G
V
M
AII
NN
I
TM
LAI
VLT
G
SAL
I
RERE
H
GTV
EH
LLV
M
P
I
T
PF
EI
M
M
A
K
V
WSM
G
L
V
V
L
V
V
SG
L
SLV
LM
VK---G
V
L
GVP
IE
GS
IP
LF
M
L
GVA
L
S
LFAT
T
S
I
G
IFMG
T
IAR
S
M
P
Q
L
GL
L
V
I
L
V
-
LLP
L
QM
LSG
GST
P
R
ESMP
---
Q
M
VQD
IMLTM
PT
T
HF
VS
L
AQ
A
I
LY
R
G
A
G
F
E
IVW
PQ
F
L
T
L
M
A
IGGAFFTIA
L
LRFRKTI
fig|550676.3.peg.3642
Escherichia coli B185 (13-370/374)
KEL
R
SLL
G
D
-
--------KA
M
L
T
LIVF
S
F
TV
SV
YSSATVTPG
S
L
N
L
A
P
IAI
A
D
M
DQ
SQL
S
NRI
V
NS
F
Y
R
PWF
L
--P
P
E
M
I
T
A
DEMD
AG
LDAG
RY
T
F
AI
N
IPPNF
Q
R
--
D
VLA
G
R
Q
P
D
I
Q
V
N
VD
A
TRM
S
Q
A
F
T
GN
GYIQ
N
I
INGEV
N
SFVA
R
YR-
-
D
NSE
P
LV
SL
ETR
M
R
F
NPNLD
PA
WF
-
-
G
G
V
M
AII
NN
I
TM
LAI
VLT
G
SAL
I
RERE
H
GTV
EH
LLV
M
P
I
T
PF
EI
M
M
A
K
V
WSM
G
L
V
V
L
V
V
SG
L
SLV
LM
VK---G
V
L
GVP
IE
GS
IP
LF
M
L
GVA
L
S
LFAT
T
S
I
G
IFMG
T
IAR
S
M
P
Q
L
GL
L
V
I
L
V
-
LLP
L
QM
LSG
GST
P
R
ESMP
---
Q
M
VQD
IMLTM
PT
T
HF
VS
L
AQ
A
I
LY
R
G
A
G
F
E
IVW
PQ
F
L
T
L
M
A
IGGAFFTIA
L
LRFRKTI
fig|199310.4.peg.4026
Escherichia coli CFT073 (13-370/374)
KEL
R
SLL
G
D
-
--------KA
M
L
T
LIVF
S
F
TV
SV
YSSATVTPG
S
L
N
L
A
P
IAI
A
D
M
DQ
SQL
S
NRI
V
NS
F
Y
R
PWF
L
--P
P
E
M
I
T
A
DEMD
AG
LDAG
RY
T
F
AI
N
IPPNF
Q
R
--
D
VLA
G
R
Q
P
D
I
Q
V
N
VD
A
TRM
S
Q
A
F
T
GN
GYIQ
N
I
INGEV
N
SFVA
R
YR-
-
D
NSE
P
LV
SL
ETR
M
R
F
NPNLD
PA
WF
-
-
G
G
V
M
AII
NN
I
TM
LAI
VLT
G
SAL
I
RERE
H
GTV
EH
LLV
M
P
I
T
PF
EI
M
M
A
K
V
WSM
G
L
V
V
L
V
V
SG
L
SLV
LM
VK---G
V
L
GVP
IE
GS
IP
LF
M
L
GVA
L
S
LFAT
T
S
I
G
IFMG
T
IAR
S
M
P
Q
L
GL
L
V
I
L
V
-
LLP
L
QM
LSG
GST
P
R
ESMP
---
Q
M
VQD
IMLTM
PT
T
HF
VS
L
AQ
A
I
LY
R
G
A
G
F
E
IVW
PQ
F
L
T
L
M
A
IGGAFFTIA
L
LRFRKTI
fig|331111.12.peg.4205
Escherichia coli E24377A (13-370/374)
KEL
R
SLL
G
D
-
--------KA
M
L
T
LIVF
S
F
TV
SV
YSSATVTPG
S
L
N
L
A
P
IAI
A
D
M
DQ
SQL
S
NRI
V
NS
F
Y
R
PWF
L
--P
P
E
M
I
T
A
DEMD
AG
LDAG
RY
T
F
AI
N
IPPNF
Q
R
--
D
VLA
G
R
Q
P
D
I
Q
V
N
VD
A
TRM
S
Q
A
F
T
GN
GYIQ
N
I
INGEV
N
SFVA
R
YR-
-
D
NSE
P
LV
SL
ETR
M
R
F
NPNLD
PA
WF
-
-
G
G
V
M
AII
NN
I
TM
LAI
VLT
G
SAL
I
RERE
H
GTV
EH
LLV
M
P
I
T
PF
EI
M
M
A
K
V
WSM
G
L
V
V
L
V
V
SG
L
SLV
LM
VK---G
V
L
GVP
IE
GS
IP
LF
M
L
GVA
L
S
LFAT
T
S
I
G
IFMG
T
IAR
S
M
P
Q
L
GL
L
V
I
L
V
-
LLP
L
QM
LSG
GST
P
R
ESMP
---
Q
M
VQD
IMLTM
PT
T
HF
VS
L
AQ
A
I
LY
R
G
A
G
F
E
IVW
PQ
F
L
T
L
M
A
IGGAFFTIA
L
LRFRKTI
fig|331111.3.peg.1620
Escherichia coli E24377A (13-370/374)
KEL
R
SLL
G
D
-
--------KA
M
L
T
LIVF
S
F
TV
SV
YSSATVTPG
S
L
N
L
A
P
IAI
A
D
M
DQ
SQL
S
NRI
V
NS
F
Y
R
PWF
L
--P
P
E
M
I
T
A
DEMD
AG
LDAG
RY
T
F
AI
N
IPPNF
Q
R
--
D
VLA
G
R
Q
P
D
I
Q
V
N
VD
A
TRM
S
Q
A
F
T
GN
GYIQ
N
I
INGEV
N
SFVA
R
YR-
-
D
NSE
P
LV
SL
ETR
M
R
F
NPNLD
PA
WF
-
-
G
G
V
M
AII
NN
I
TM
LAI
VLT
G
SAL
I
RERE
H
GTV
EH
LLV
M
P
I
T
PF
EI
M
M
A
K
V
WSM
G
L
V
V
L
V
V
SG
L
SLV
LM
VK---G
V
L
GVP
IE
GS
IP
LF
M
L
GVA
L
S
LFAT
T
S
I
G
IFMG
T
IAR
S
M
P
Q
L
GL
L
V
I
L
V
-
LLP
L
QM
LSG
GST
P
R
ESMP
---
Q
M
VQD
IMLTM
PT
T
HF
VS
L
AQ
A
I
LY
R
G
A
G
F
E
IVW
PQ
F
L
T
L
M
A
IGGAFFTIA
L
LRFRKTI
fig|562.375.peg.4837
Escherichia coli EC4100B (13-370/374)
KEL
R
SLL
G
D
-
--------KA
M
L
T
LIVF
S
F
TV
SV
YSSATVTPG
S
L
N
L
A
P
IAI
A
D
M
DQ
SQL
S
NRI
V
NS
F
Y
R
PWF
L
--P
P
E
M
I
T
A
DEMD
AG
LDAG
RY
T
F
AI
N
IPPNF
Q
R
--
D
VLA
G
R
Q
P
D
I
Q
V
N
VD
A
TRM
S
Q
A
F
T
GN
GYIQ
N
I
INGEV
N
SFVA
R
YR-
-
D
NSE
P
LV
SL
ETR
M
R
F
NPNLD
PA
WF
-
-
G
G
V
M
AII
NN
I
TM
LAI
VLT
G
SAL
I
RERE
H
GTV
EH
LLV
M
P
I
T
PF
EI
M
M
A
K
V
WSM
G
L
V
V
L
V
V
SG
L
SLV
LM
VK---G
V
L
GVP
IE
GS
IP
LF
M
L
GVA
L
S
LFAT
T
S
I
G
IFMG
T
IAR
S
M
P
Q
L
GL
L
V
I
L
V
-
LLP
L
QM
LSG
GST
P
R
ESMP
---
Q
M
VQD
IMLTM
PT
T
HF
VS
L
AQ
A
I
LY
R
G
A
G
F
E
IVW
PQ
F
L
T
L
M
A
IGGAFFTIA
L
LRFRKTI
fig|656408.3.peg.3907
Escherichia coli H591 (13-370/374)
KEL
R
SLL
G
D
-
--------KA
M
L
T
LIVF
S
F
TV
SV
YSSATVTPG
S
L
N
L
A
P
IAI
A
D
M
DQ
SQL
S
NRI
V
NS
F
Y
R
PWF
L
--P
P
E
M
I
T
A
DEMD
AG
LDAG
RY
T
F
AI
N
IPPNF
Q
R
--
D
VLA
G
R
Q
P
D
I
Q
V
N
VD
A
TRM
S
Q
A
F
T
GN
GYIQ
N
I
INGEV
N
SFVA
R
YR-
-
D
NSE
P
LV
SL
ETR
M
R
F
NPNLD
PA
WF
-
-
G
G
V
M
AII
NN
I
TM
LAI
VLT
G
SAL
I
RERE
H
GTV
EH
LLV
M
P
I
T
PF
EI
M
M
A
K
V
WSM
G
L
V
V
L
V
V
SG
L
SLV
LM
VK---G
V
L
GVP
IE
GS
IP
LF
M
L
GVA
L
S
LFAT
T
S
I
G
IFMG
T
IAR
S
M
P
Q
L
GL
L
V
I
L
V
-
LLP
L
QM
LSG
GST
P
R
ESMP
---
Q
M
VQD
IMLTM
PT
T
HF
VS
L
AQ
A
I
LY
R
G
A
G
F
E
IVW
PQ
F
L
T
L
M
A
IGGAFFTIA
L
LRFRKTI
fig|585034.4.peg.3550
Escherichia coli IAI1 (13-370/374)
KEL
R
SLL
G
D
-
--------KA
M
L
T
LIVF
S
F
TV
SV
YSSATVTPG
S
L
N
L
A
P
IAI
A
D
M
DQ
SQL
S
NRI
V
NS
F
Y
R
PWF
L
--P
P
E
M
I
T
A
DEMD
AG
LDAG
RY
T
F
AI
N
IPPNF
Q
R
--
D
VLA
G
R
Q
P
D
I
Q
V
N
VD
A
TRM
S
Q
A
F
T
GN
GYIQ
N
I
INGEV
N
SFVA
R
YR-
-
D
NSE
P
LV
SL
ETR
M
R
F
NPNLD
PA
WF
-
-
G
G
V
M
AII
NN
I
TM
LAI
VLT
G
SAL
I
RERE
H
GTV
EH
LLV
M
P
I
T
PF
EI
M
M
A
K
V
WSM
G
L
V
V
L
V
V
SG
L
SLV
LM
VK---G
V
L
GVP
IE
GS
IP
LF
M
L
GVA
L
S
LFAT
T
S
I
G
IFMG
T
IAR
S
M
P
Q
L
GL
L
V
I
L
V
-
LLP
L
QM
LSG
GST
P
R
ESMP
---
Q
M
VQD
IMLTM
PT
T
HF
VS
L
AQ
A
I
LY
R
G
A
G
F
E
IVW
PQ
F
L
T
L
M
A
IGGAFFTIA
L
LRFRKTI
fig|585034.5.peg.3548
Escherichia coli IAI1 (13-370/374)
KEL
R
SLL
G
D
-
--------KA
M
L
T
LIVF
S
F
TV
SV
YSSATVTPG
S
L
N
L
A
P
IAI
A
D
M
DQ
SQL
S
NRI
V
NS
F
Y
R
PWF
L
--P
P
E
M
I
T
A
DEMD
AG
LDAG
RY
T
F
AI
N
IPPNF
Q
R
--
D
VLA
G
R
Q
P
D
I
Q
V
N
VD
A
TRM
S
Q
A
F
T
GN
GYIQ
N
I
INGEV
N
SFVA
R
YR-
-
D
NSE
P
LV
SL
ETR
M
R
F
NPNLD
PA
WF
-
-
G
G
V
M
AII
NN
I
TM
LAI
VLT
G
SAL
I
RERE
H
GTV
EH
LLV
M
P
I
T
PF
EI
M
M
A
K
V
WSM
G
L
V
V
L
V
V
SG
L
SLV
LM
VK---G
V
L
GVP
IE
GS
IP
LF
M
L
GVA
L
S
LFAT
T
S
I
G
IFMG
T
IAR
S
M
P
Q
L
GL
L
V
I
L
V
-
LLP
L
QM
LSG
GST
P
R
ESMP
---
Q
M
VQD
IMLTM
PT
T
HF
VS
L
AQ
A
I
LY
R
G
A
G
F
E
IVW
PQ
F
L
T
L
M
A
IGGAFFTIA
L
LRFRKTI
fig|585057.4.peg.4105
Escherichia coli IAI39 (13-370/374)
KEL
R
SLL
G
D
-
--------KA
M
L
T
LIVF
S
F
TV
SV
YSSATVTPG
S
L
N
L
A
P
IAI
A
D
M
DQ
SQL
S
NRI
V
NS
F
Y
R
PWF
L
--P
P
E
M
I
T
A
DEMD
AG
LDAG
RY
T
F
AI
N
IPPNF
Q
R
--
D
VLA
G
R
Q
P
D
I
Q
V
N
VD
A
TRM
S
Q
A
F
T
GN
GYIQ
N
I
INGEV
N
SFVA
R
YR-
-
D
NSE
P
LV
SL
ETR
M
R
F
NPNLD
PA
WF
-
-
G
G
V
M
AII
NN
I
TM
LAI
VLT
G
SAL
I
RERE
H
GTV
EH
LLV
M
P
I
T
PF
EI
M
M
A
K
V
WSM
G
L
V
V
L
V
V
SG
L
SLV
LM
VK---G
V
L
GVP
IE
GS
IP
LF
M
L
GVA
L
S
LFAT
T
S
I
G
IFMG
T
IAR
S
M
P
Q
L
GL
L
V
I
L
V
-
LLP
L
QM
LSG
GST
P
R
ESMP
---
Q
M
VQD
IMLTM
PT
T
HF
VS
L
AQ
A
I
LY
R
G
A
G
F
E
IVW
PQ
F
L
T
L
M
A
IGGAFFTIA
L
LRFRKTI
fig|585057.6.peg.4113
Escherichia coli IAI39 (13-370/374)
KEL
R
SLL
G
D
-
--------KA
M
L
T
LIVF
S
F
TV
SV
YSSATVTPG
S
L
N
L
A
P
IAI
A
D
M
DQ
SQL
S
NRI
V
NS
F
Y
R
PWF
L
--P
P
E
M
I
T
A
DEMD
AG
LDAG
RY
T
F
AI
N
IPPNF
Q
R
--
D
VLA
G
R
Q
P
D
I
Q
V
N
VD
A
TRM
S
Q
A
F
T
GN
GYIQ
N
I
INGEV
N
SFVA
R
YR-
-
D
NSE
P
LV
SL
ETR
M
R
F
NPNLD
PA
WF
-
-
G
G
V
M
AII
NN
I
TM
LAI
VLT
G
SAL
I
RERE
H
GTV
EH
LLV
M
P
I
T
PF
EI
M
M
A
K
V
WSM
G
L
V
V
L
V
V
SG
L
SLV
LM
VK---G
V
L
GVP
IE
GS
IP
LF
M
L
GVA
L
S
LFAT
T
S
I
G
IFMG
T
IAR
S
M
P
Q
L
GL
L
V
I
L
V
-
LLP
L
QM
LSG
GST
P
R
ESMP
---
Q
M
VQD
IMLTM
PT
T
HF
VS
L
AQ
A
I
LY
R
G
A
G
F
E
IVW
PQ
F
L
T
L
M
A
IGGAFFTIA
L
LRFRKTI
fig|714962.3.peg.3953
Escherichia coli IHE3034 (13-370/374)
KEL
R
SLL
G
D
-
--------KA
M
L
T
LIVF
S
F
TV
SV
YSSATVTPG
S
L
N
L
A
P
IAI
A
D
M
DQ
SQL
S
NRI
V
NS
F
Y
R
PWF
L
--P
P
E
M
I
T
A
DEMD
AG
LDAG
RY
T
F
AI
N
IPPNF
Q
R
--
D
VLA
G
R
Q
P
D
I
Q
V
N
VD
A
TRM
S
Q
A
F
T
GN
GYIQ
N
I
INGEV
N
SFVA
R
YR-
-
D
NSE
P
LV
SL
ETR
M
R
F
NPNLD
PA
WF
-
-
G
G
V
M
AII
NN
I
TM
LAI
VLT
G
SAL
I
RERE
H
GTV
EH
LLV
M
P
I
T
PF
EI
M
M
A
K
V
WSM
G
L
V
V
L
V
V
SG
L
SLV
LM
VK---G
V
L
GVP
IE
GS
IP
LF
M
L
GVA
L
S
LFAT
T
S
I
G
IFMG
T
IAR
S
M
P
Q
L
GL
L
V
I
L
V
-
LLP
L
QM
LSG
GST
P
R
ESMP
---
Q
M
VQD
IMLTM
PT
T
HF
VS
L
AQ
A
I
LY
R
G
A
G
F
E
IVW
PQ
F
L
T
L
M
A
IGGAFFTIA
L
LRFRKTI
fig|595495.4.peg.1423
Escherichia coli KO11 (13-370/374)
KEL
R
SLL
G
D
-
--------KA
M
L
T
LIVF
S
F
TV
SV
YSSATVTPG
S
L
N
L
A
P
IAI
A
D
M
DQ
SQL
S
NRI
V
NS
F
Y
R
PWF
L
--P
P
E
M
I
T
A
DEMD
AG
LDAG
RY
T
F
AI
N
IPPNF
Q
R
--
D
VLA
G
R
Q
P
D
I
Q
V
N
VD
A
TRM
S
Q
A
F
T
GN
GYIQ
N
I
INGEV
N
SFVA
R
YR-
-
D
NSE
P
LV
SL
ETR
M
R
F
NPNLD
PA
WF
-
-
G
G
V
M
AII
NN
I
TM
LAI
VLT
G
SAL
I
RERE
H
GTV
EH
LLV
M
P
I
T
PF
EI
M
M
A
K
V
WSM
G
L
V
V
L
V
V
SG
L
SLV
LM
VK---G
V
L
GVP
IE
GS
IP
LF
M
L
GVA
L
S
LFAT
T
S
I
G
IFMG
T
IAR
S
M
P
Q
L
GL
L
V
I
L
V
-
LLP
L
QM
LSG
GST
P
R
ESMP
---
Q
M
VQD
IMLTM
PT
T
HF
VS
L
AQ
A
I
LY
R
G
A
G
F
E
IVW
PQ
F
L
T
L
M
A
IGGAFFTIA
L
LRFRKTI
fig|656419.3.peg.4484
Escherichia coli M718 (13-370/374)
KEL
R
SLL
G
D
-
--------KA
M
L
T
LIVF
S
F
TV
SV
YSSATVTPG
S
L
N
L
A
P
IAI
A
D
M
DQ
SQL
S
NRI
V
NS
F
Y
R
PWF
L
--P
P
E
M
I
T
A
DEMD
AG
LDAG
RY
T
F
AI
N
IPPNF
Q
R
--
D
VLA
G
R
Q
P
D
I
Q
V
N
VD
A
TRM
S
Q
A
F
T
GN
GYIQ
N
I
INGEV
N
SFVA
R
YR-
-
D
NSE
P
LV
SL
ETR
M
R
F
NPNLD
PA
WF
-
-
G
G
V
M
AII
NN
I
TM
LAI
VLT
G
SAL
I
RERE
H
GTV
EH
LLV
M
P
I
T
PF
EI
M
M
A
K
V
WSM
G
L
V
V
L
V
V
SG
L
SLV
LM
VK---G
V
L
GVP
IE
GS
IP
LF
M
L
GVA
L
S
LFAT
T
S
I
G
IFMG
T
IAR
S
M
P
Q
L
GL
L
V
I
L
V
-
LLP
L
QM
LSG
GST
P
R
ESMP
---
Q
M
VQD
IMLTM
PT
T
HF
VS
L
AQ
A
I
LY
R
G
A
G
F
E
IVW
PQ
F
L
T
L
M
A
IGGAFFTIA
L
LRFRKTI
fig|679207.4.peg.326
Escherichia coli MS 107-1 (13-370/374)
KEL
R
SLL
G
D
-
--------KA
M
L
T
LIVF
S
F
TV
SV
YSSATVTPG
S
L
N
L
A
P
IAI
A
D
M
DQ
SQL
S
NRI
V
NS
F
Y
R
PWF
L
--P
P
E
M
I
T
A
DEMD
AG
LDAG
RY
T
F
AI
N
IPPNF
Q
R
--
D
VLA
G
R
Q
P
D
I
Q
V
N
VD
A
TRM
S
Q
A
F
T
GN
GYIQ
N
I
INGEV
N
SFVA
R
YR-
-
D
NSE
P
LV
SL
ETR
M
R
F
NPNLD
PA
WF
-
-
G
G
V
M
AII
NN
I
TM
LAI
VLT
G
SAL
I
RERE
H
GTV
EH
LLV
M
P
I
T
PF
EI
M
M
A
K
V
WSM
G
L
V
V
L
V
V
SG
L
SLV
LM
VK---G
V
L
GVP
IE
GS
IP
LF
M
L
GVA
L
S
LFAT
T
S
I
G
IFMG
T
IAR
S
M
P
Q
L
GL
L
V
I
L
V
-
LLP
L
QM
LSG
GST
P
R
ESMP
---
Q
M
VQD
IMLTM
PT
T
HF
VS
L
AQ
A
I
LY
R
G
A
G
F
E
IVW
PQ
F
L
T
L
M
A
IGGAFFTIA
L
LRFRKTI
fig|679206.4.peg.2484
Escherichia coli MS 119-7 (13-370/374)
KEL
R
SLL
G
D
-
--------KA
M
L
T
LIVF
S
F
TV
SV
YSSATVTPG
S
L
N
L
A
P
IAI
A
D
M
DQ
SQL
S
NRI
V
NS
F
Y
R
PWF
L
--P
P
E
M
I
T
A
DEMD
AG
LDAG
RY
T
F
AI
N
IPPNF
Q
R
--
D
VLA
G
R
Q
P
D
I
Q
V
N
VD
A
TRM
S
Q
A
F
T
GN
GYIQ
N
I
INGEV
N
SFVA
R
YR-
-
D
NSE
P
LV
SL
ETR
M
R
F
NPNLD
PA
WF
-
-
G
G
V
M
AII
NN
I
TM
LAI
VLT
G
SAL
I
RERE
H
GTV
EH
LLV
M
P
I
T
PF
EI
M
M
A
K
V
WSM
G
L
V
V
L
V
V
SG
L
SLV
LM
VK---G
V
L
GVP
IE
GS
IP
LF
M
L
GVA
L
S
LFAT
T
S
I
G
IFMG
T
IAR
S
M
P
Q
L
GL
L
V
I
L
V
-
LLP
L
QM
LSG
GST
P
R
ESMP
---
Q
M
VQD
IMLTM
PT
T
HF
VS
L
AQ
A
I
LY
R
G
A
G
F
E
IVW
PQ
F
L
T
L
M
A
IGGAFFTIA
L
LRFRKTI
fig|679205.4.peg.4435
Escherichia coli MS 124-1 (13-370/374)
KEL
R
SLL
G
D
-
--------KA
M
L
T
LIVF
S
F
TV
SV
YSSATVTPG
S
L
N
L
A
P
IAI
A
D
M
DQ
SQL
S
NRI
V
NS
F
Y
R
PWF
L
--P
P
E
M
I
T
A
DEMD
AG
LDAG
RY
T
F
AI
N
IPPNF
Q
R
--
D
VLA
G
R
Q
P
D
I
Q
V
N
VD
A
TRM
S
Q
A
F
T
GN
GYIQ
N
I
INGEV
N
SFVA
R
YR-
-
D
NSE
P
LV
SL
ETR
M
R
F
NPNLD
PA
WF
-
-
G
G
V
M
AII
NN
I
TM
LAI
VLT
G
SAL
I
RERE
H
GTV
EH
LLV
M
P
I
T
PF
EI
M
M
A
K
V
WSM
G
L
V
V
L
V
V
SG
L
SLV
LM
VK---G
V
L
GVP
IE
GS
IP
LF
M
L
GVA
L
S
LFAT
T
S
I
G
IFMG
T
IAR
S
M
P
Q
L
GL
L
V
I
L
V
-
LLP
L
QM
LSG
GST
P
R
ESMP
---
Q
M
VQD
IMLTM
PT
T
HF
VS
L
AQ
A
I
LY
R
G
A
G
F
E
IVW
PQ
F
L
T
L
M
A
IGGAFFTIA
L
LRFRKTI
fig|749545.3.peg.4613
Escherichia coli MS 182-1 (13-370/374)
KEL
R
SLL
G
D
-
--------KA
M
L
T
LIVF
S
F
TV
SV
YSSATVTPG
S
L
N
L
A
P
IAI
A
D
M
DQ
SQL
S
NRI
V
NS
F
Y
R
PWF
L
--P
P
E
M
I
T
A
DEMD
AG
LDAG
RY
T
F
AI
N
IPPNF
Q
R
--
D
VLA
G
R
Q
P
D
I
Q
V
N
VD
A
TRM
S
Q
A
F
T
GN
GYIQ
N
I
INGEV
N
SFVA
R
YR-
-
D
NSE
P
LV
SL
ETR
M
R
F
NPNLD
PA
WF
-
-
G
G
V
M
AII
NN
I
TM
LAI
VLT
G
SAL
I
RERE
H
GTV
EH
LLV
M
P
I
T
PF
EI
M
M
A
K
V
WSM
G
L
V
V
L
V
V
SG
L
SLV
LM
VK---G
V
L
GVP
IE
GS
IP
LF
M
L
GVA
L
S
LFAT
T
S
I
G
IFMG
T
IAR
S
M
P
Q
L
GL
L
V
I
L
V
-
LLP
L
QM
LSG
GST
P
R
ESMP
---
Q
M
VQD
IMLTM
PT
T
HF
VS
L
AQ
A
I
LY
R
G
A
G
F
E
IVW
PQ
F
L
T
L
M
A
IGGAFFTIA
L
LRFRKTI
fig|749546.3.peg.3977
Escherichia coli MS 185-1 (13-370/374)
KEL
R
SLL
G
D
-
--------KA
M
L
T
LIVF
S
F
TV
SV
YSSATVTPG
S
L
N
L
A
P
IAI
A
D
M
DQ
SQL
S
NRI
V
NS
F
Y
R
PWF
L
--P
P
E
M
I
T
A
DEMD
AG
LDAG
RY
T
F
AI
N
IPPNF
Q
R
--
D
VLA
G
R
Q
P
D
I
Q
V
N
VD
A
TRM
S
Q
A
F
T
GN
GYIQ
N
I
INGEV
N
SFVA
R
YR-
-
D
NSE
P
LV
SL
ETR
M
R
F
NPNLD
PA
WF
-
-
G
G
V
M
AII
NN
I
TM
LAI
VLT
G
SAL
I
RERE
H
GTV
EH
LLV
M
P
I
T
PF
EI
M
M
A
K
V
WSM
G
L
V
V
L
V
V
SG
L
SLV
LM
VK---G
V
L
GVP
IE
GS
IP
LF
M
L
GVA
L
S
LFAT
T
S
I
G
IFMG
T
IAR
S
M
P
Q
L
GL
L
V
I
L
V
-
LLP
L
QM
LSG
GST
P
R
ESMP
---
Q
M
VQD
IMLTM
PT
T
HF
VS
L
AQ
A
I
LY
R
G
A
G
F
E
IVW
PQ
F
L
T
L
M
A
IGGAFFTIA
L
LRFRKTI
fig|749527.3.peg.1359
Escherichia coli MS 21-1 (13-370/374)
KEL
R
SLL
G
D
-
--------KA
M
L
T
LIVF
S
F
TV
SV
YSSATVTPG
S
L
N
L
A
P
IAI
A
D
M
DQ
SQL
S
NRI
V
NS
F
Y
R
PWF
L
--P
P
E
M
I
T
A
DEMD
AG
LDAG
RY
T
F
AI
N
IPPNF
Q
R
--
D
VLA
G
R
Q
P
D
I
Q
V
N
VD
A
TRM
S
Q
A
F
T
GN
GYIQ
N
I
INGEV
N
SFVA
R
YR-
-
D
NSE
P
LV
SL
ETR
M
R
F
NPNLD
PA
WF
-
-
G
G
V
M
AII
NN
I
TM
LAI
VLT
G
SAL
I
RERE
H
GTV
EH
LLV
M
P
I
T
PF
EI
M
M
A
K
V
WSM
G
L
V
V
L
V
V
SG
L
SLV
LM
VK---G
V
L
GVP
IE
GS
IP
LF
M
L
GVA
L
S
LFAT
T
S
I
G
IFMG
T
IAR
S
M
P
Q
L
GL
L
V
I
L
V
-
LLP
L
QM
LSG
GST
P
R
ESMP
---
Q
M
VQD
IMLTM
PT
T
HF
VS
L
AQ
A
I
LY
R
G
A
G
F
E
IVW
PQ
F
L
T
L
M
A
IGGAFFTIA
L
LRFRKTI
fig|749528.3.peg.3036
Escherichia coli MS 45-1 (13-370/374)
KEL
R
SLL
G
D
-
--------KA
M
L
T
LIVF
S
F
TV
SV
YSSATVTPG
S
L
N
L
A
P
IAI
A
D
M
DQ
SQL
S
NRI
V
NS
F
Y
R
PWF
L
--P
P
E
M
I
T
A
DEMD
AG
LDAG
RY
T
F
AI
N
IPPNF
Q
R
--
D
VLA
G
R
Q
P
D
I
Q
V
N
VD
A
TRM
S
Q
A
F
T
GN
GYIQ
N
I
INGEV
N
SFVA
R
YR-
-
D
NSE
P
LV
SL
ETR
M
R
F
NPNLD
PA
WF
-
-
G
G
V
M
AII
NN
I
TM
LAI
VLT
G
SAL
I
RERE
H
GTV
EH
LLV
M
P
I
T
PF
EI
M
M
A
K
V
WSM
G
L
V
V
L
V
V
SG
L
SLV
LM
VK---G
V
L
GVP
IE
GS
IP
LF
M
L
GVA
L
S
LFAT
T
S
I
G
IFMG
T
IAR
S
M
P
Q
L
GL
L
V
I
L
V
-
LLP
L
QM
LSG
GST
P
R
ESMP
---
Q
M
VQD
IMLTM
PT
T
HF
VS
L
AQ
A
I
LY
R
G
A
G
F
E
IVW
PQ
F
L
T
L
M
A
IGGAFFTIA
L
LRFRKTI
fig|749532.3.peg.4046
Escherichia coli MS 78-1 (13-370/374)
KEL
R
SLL
G
D
-
--------KA
M
L
T
LIVF
S
F
TV
SV
YSSATVTPG
S
L
N
L
A
P
IAI
A
D
M
DQ
SQL
S
NRI
V
NS
F
Y
R
PWF
L
--P
P
E
M
I
T
A
DEMD
AG
LDAG
RY
T
F
AI
N
IPPNF
Q
R
--
D
VLA
G
R
Q
P
D
I
Q
V
N
VD
A
TRM
S
Q
A
F
T
GN
GYIQ
N
I
INGEV
N
SFVA
R
YR-
-
D
NSE
P
LV
SL
ETR
M
R
F
NPNLD
PA
WF
-
-
G
G
V
M
AII
NN
I
TM
LAI
VLT
G
SAL
I
RERE
H
GTV
EH
LLV
M
P
I
T
PF
EI
M
M
A
K
V
WSM
G
L
V
V
L
V
V
SG
L
SLV
LM
VK---G
V
L
GVP
IE
GS
IP
LF
M
L
GVA
L
S
LFAT
T
S
I
G
IFMG
T
IAR
S
M
P
Q
L
GL
L
V
I
L
V
-
LLP
L
QM
LSG
GST
P
R
ESMP
---
Q
M
VQD
IMLTM
PT
T
HF
VS
L
AQ
A
I
LY
R
G
A
G
F
E
IVW
PQ
F
L
T
L
M
A
IGGAFFTIA
L
LRFRKTI
fig|749533.3.peg.5101
Escherichia coli MS 84-1 (13-370/374)
KEL
R
SLL
G
D
-
--------KA
M
L
T
LIVF
S
F
TV
SV
YSSATVTPG
S
L
N
L
A
P
IAI
A
D
M
DQ
SQL
S
NRI
V
NS
F
Y
R
PWF
L
--P
P
E
M
I
T
A
DEMD
AG
LDAG
RY
T
F
AI
N
IPPNF
Q
R
--
D
VLA
G
R
Q
P
D
I
Q
V
N
VD
A
TRM
S
Q
A
F
T
GN
GYIQ
N
I
INGEV
N
SFVA
R
YR-
-
D
NSE
P
LV
SL
ETR
M
R
F
NPNLD
PA
WF
-
-
G
G
V
M
AII
NN
I
TM
LAI
VLT
G
SAL
I
RERE
H
GTV
EH
LLV
M
P
I
T
PF
EI
M
M
A
K
V
WSM
G
L
V
V
L
V
V
SG
L
SLV
LM
VK---G
V
L
GVP
IE
GS
IP
LF
M
L
GVA
L
S
LFAT
T
S
I
G
IFMG
T
IAR
S
M
P
Q
L
GL
L
V
I
L
V
-
LLP
L
QM
LSG
GST
P
R
ESMP
---
Q
M
VQD
IMLTM
PT
T
HF
VS
L
AQ
A
I
LY
R
G
A
G
F
E
IVW
PQ
F
L
T
L
M
A
IGGAFFTIA
L
LRFRKTI
fig|753642.3.peg.4462
Escherichia coli NC101 (13-370/374)
KEL
R
SLL
G
D
-
--------KA
M
L
T
LIVF
S
F
TV
SV
YSSATVTPG
S
L
N
L
A
P
IAI
A
D
M
DQ
SQL
S
NRI
V
NS
F
Y
R
PWF
L
--P
P
E
M
I
T
A
DEMD
AG
LDAG
RY
T
F
AI
N
IPPNF
Q
R
--
D
VLA
G
R
Q
P
D
I
Q
V
N
VD
A
TRM
S
Q
A
F
T
GN
GYIQ
N
I
INGEV
N
SFVA
R
YR-
-
D
NSE
P
LV
SL
ETR
M
R
F
NPNLD
PA
WF
-
-
G
G
V
M
AII
NN
I
TM
LAI
VLT
G
SAL
I
RERE
H
GTV
EH
LLV
M
P
I
T
PF
EI
M
M
A
K
V
WSM
G
L
V
V
L
V
V
SG
L
SLV
LM
VK---G
V
L
GVP
IE
GS
IP
LF
M
L
GVA
L
S
LFAT
T
S
I
G
IFMG
T
IAR
S
M
P
Q
L
GL
L
V
I
L
V
-
LLP
L
QM
LSG
GST
P
R
ESMP
---
Q
M
VQD
IMLTM
PT
T
HF
VS
L
AQ
A
I
LY
R
G
A
G
F
E
IVW
PQ
F
L
T
L
M
A
IGGAFFTIA
L
LRFRKTI
fig|585396.4.peg.4442
Escherichia coli O111:H- str. 11128 (13-370/374)
KEL
R
SLL
G
D
-
--------KA
M
L
T
LIVF
S
F
TV
SV
YSSATVTPG
S
L
N
L
A
P
IAI
A
D
M
DQ
SQL
S
NRI
V
NS
F
Y
R
PWF
L
--P
P
E
M
I
T
A
DEMD
AG
LDAG
RY
T
F
AI
N
IPPNF
Q
R
--
D
VLA
G
R
Q
P
D
I
Q
V
N
VD
A
TRM
S
Q
A
F
T
GN
GYIQ
N
I
INGEV
N
SFVA
R
YR-
-
D
NSE
P
LV
SL
ETR
M
R
F
NPNLD
PA
WF
-
-
G
G
V
M
AII
NN
I
TM
LAI
VLT
G
SAL
I
RERE
H
GTV
EH
LLV
M
P
I
T
PF
EI
M
M
A
K
V
WSM
G
L
V
V
L
V
V
SG
L
SLV
LM
VK---G
V
L
GVP
IE
GS
IP
LF
M
L
GVA
L
S
LFAT
T
S
I
G
IFMG
T
IAR
S
M
P
Q
L
GL
L
V
I
L
V
-
LLP
L
QM
LSG
GST
P
R
ESMP
---
Q
M
VQD
IMLTM
PT
T
HF
VS
L
AQ
A
I
LY
R
G
A
G
F
E
IVW
PQ
F
L
T
L
M
A
IGGAFFTIA
L
LRFRKTI
fig|574521.7.peg.3808
Escherichia coli O127:H6 str. E2348/69 (13-370/374)
KEL
R
SLL
G
D
-
--------KA
M
L
T
LIVF
S
F
TV
SV
YSSATVTPG
S
L
N
L
A
P
IAI
A
D
M
DQ
SQL
S
NRI
V
NS
F
Y
R
PWF
L
--P
P
E
M
I
T
A
DEMD
AG
LDAG
RY
T
F
AI
N
IPPNF
Q
R
--
D
VLA
G
R
Q
P
D
I
Q
V
N
VD
A
TRM
S
Q
A
F
T
GN
GYIQ
N
I
INGEV
N
SFVA
R
YR-
-
D
NSE
P
LV
SL
ETR
M
R
F
NPNLD
PA
WF
-
-
G
G
V
M
AII
NN
I
TM
LAI
VLT
G
SAL
I
RERE
H
GTV
EH
LLV
M
P
I
T
PF
EI
M
M
A
K
V
WSM
G
L
V
V
L
V
V
SG
L
SLV
LM
VK---G
V
L
GVP
IE
GS
IP
LF
M
L
GVA
L
S
LFAT
T
S
I
G
IFMG
T
IAR
S
M
P
Q
L
GL
L
V
I
L
V
-
LLP
L
QM
LSG
GST
P
R
ESMP
---
Q
M
VQD
IMLTM
PT
T
HF
VS
L
AQ
A
I
LY
R
G
A
G
F
E
IVW
PQ
F
L
T
L
M
A
IGGAFFTIA
L
LRFRKTI
fig|573235.3.peg.4685
Escherichia coli O26:H11 str. 11368 (13-370/374)
KEL
R
SLL
G
D
-
--------KA
M
L
T
LIVF
S
F
TV
SV
YSSATVTPG
S
L
N
L
A
P
IAI
A
D
M
DQ
SQL
S
NRI
V
NS
F
Y
R
PWF
L
--P
P
E
M
I
T
A
DEMD
AG
LDAG
RY
T
F
AI
N
IPPNF
Q
R
--
D
VLA
G
R
Q
P
D
I
Q
V
N
VD
A
TRM
S
Q
A
F
T
GN
GYIQ
N
I
INGEV
N
SFVA
R
YR-
-
D
NSE
P
LV
SL
ETR
M
R
F
NPNLD
PA
WF
-
-
G
G
V
M
AII
NN
I
TM
LAI
VLT
G
SAL
I
RERE
H
GTV
EH
LLV
M
P
I
T
PF
EI
M
M
A
K
V
WSM
G
L
V
V
L
V
V
SG
L
SLV
LM
VK---G
V
L
GVP
IE
GS
IP
LF
M
L
GVA
L
S
LFAT
T
S
I
G
IFMG
T
IAR
S
M
P
Q
L
GL
L
V
I
L
V
-
LLP
L
QM
LSG
GST
P
R
ESMP
---
Q
M
VQD
IMLTM
PT
T
HF
VS
L
AQ
A
I
LY
R
G
A
G
F
E
IVW
PQ
F
L
T
L
M
A
IGGAFFTIA
L
LRFRKTI
fig|685038.3.peg.3531
Escherichia coli O83:H1 str. NRG 857C (13-370/374)
KEL
R
SLL
G
D
-
--------KA
M
L
T
LIVF
S
F
TV
SV
YSSATVTPG
S
L
N
L
A
P
IAI
A
D
M
DQ
SQL
S
NRI
V
NS
F
Y
R
PWF
L
--P
P
E
M
I
T
A
DEMD
AG
LDAG
RY
T
F
AI
N
IPPNF
Q
R
--
D
VLA
G
R
Q
P
D
I
Q
V
N
VD
A
TRM
S
Q
A
F
T
GN
GYIQ
N
I
INGEV
N
SFVA
R
YR-
-
D
NSE
P
LV
SL
ETR
M
R
F
NPNLD
PA
WF
-
-
G
G
V
M
AII
NN
I
TM
LAI
VLT
G
SAL
I
RERE
H
GTV
EH
LLV
M
P
I
T
PF
EI
M
M
A
K
V
WSM
G
L
V
V
L
V
V
SG
L
SLV
LM
VK---G
V
L
GVP
IE
GS
IP
LF
M
L
GVA
L
S
LFAT
T
S
I
G
IFMG
T
IAR
S
M
P
Q
L
GL
L
V
I
L
V
-
LLP
L
QM
LSG
GST
P
R
ESMP
---
Q
M
VQD
IMLTM
PT
T
HF
VS
L
AQ
A
I
LY
R
G
A
G
F
E
IVW
PQ
F
L
T
L
M
A
IGGAFFTIA
L
LRFRKTI
fig|585035.6.peg.3816
Escherichia coli S88 (13-370/374)
KEL
R
SLL
G
D
-
--------KA
M
L
T
LIVF
S
F
TV
SV
YSSATVTPG
S
L
N
L
A
P
IAI
A
D
M
DQ
SQL
S
NRI
V
NS
F
Y
R
PWF
L
--P
P
E
M
I
T
A
DEMD
AG
LDAG
RY
T
F
AI
N
IPPNF
Q
R
--
D
VLA
G
R
Q
P
D
I
Q
V
N
VD
A
TRM
S
Q
A
F
T
GN
GYIQ
N
I
INGEV
N
SFVA
R
YR-
-
D
NSE
P
LV
SL
ETR
M
R
F
NPNLD
PA
WF
-
-
G
G
V
M
AII
NN
I
TM
LAI
VLT
G
SAL
I
RERE
H
GTV
EH
LLV
M
P
I
T
PF
EI
M
M
A
K
V
WSM
G
L
V
V
L
V
V
SG
L
SLV
LM
VK---G
V
L
GVP
IE
GS
IP
LF
M
L
GVA
L
S
LFAT
T
S
I
G
IFMG
T
IAR
S
M
P
Q
L
GL
L
V
I
L
V
-
LLP
L
QM
LSG
GST
P
R
ESMP
---
Q
M
VQD
IMLTM
PT
T
HF
VS
L
AQ
A
I
LY
R
G
A
G
F
E
IVW
PQ
F
L
T
L
M
A
IGGAFFTIA
L
LRFRKTI
fig|439855.10.peg.3921
Escherichia coli SMS-3-5 (13-370/374)
KEL
R
SLL
G
D
-
--------KA
M
L
T
LIVF
S
F
TV
SV
YSSATVTPG
S
L
N
L
A
P
IAI
A
D
M
DQ
SQL
S
NRI
V
NS
F
Y
R
PWF
L
--P
P
E
M
I
T
A
DEMD
AG
LDAG
RY
T
F
AI
N
IPPNF
Q
R
--
D
VLA
G
R
Q
P
D
I
Q
V
N
VD
A
TRM
S
Q
A
F
T
GN
GYIQ
N
I
INGEV
N
SFVA
R
YR-
-
D
NSE
P
LV
SL
ETR
M
R
F
NPNLD
PA
WF
-
-
G
G
V
M
AII
NN
I
TM
LAI
VLT
G
SAL
I
RERE
H
GTV
EH
LLV
M
P
I
T
PF
EI
M
M
A
K
V
WSM
G
L
V
V
L
V
V
SG
L
SLV
LM
VK---G
V
L
GVP
IE
GS
IP
LF
M
L
GVA
L
S
LFAT
T
S
I
G
IFMG
T
IAR
S
M
P
Q
L
GL
L
V
I
L
V
-
LLP
L
QM
LSG
GST
P
R
ESMP
---
Q
M
VQD
IMLTM
PT
T
HF
VS
L
AQ
A
I
LY
R
G
A
G
F
E
IVW
PQ
F
L
T
L
M
A
IGGAFFTIA
L
LRFRKTI
fig|656440.3.peg.3738
Escherichia coli TA206 (13-370/374)
KEL
R
SLL
G
D
-
--------KA
M
L
T
LIVF
S
F
TV
SV
YSSATVTPG
S
L
N
L
A
P
IAI
A
D
M
DQ
SQL
S
NRI
V
NS
F
Y
R
PWF
L
--P
P
E
M
I
T
A
DEMD
AG
LDAG
RY
T
F
AI
N
IPPNF
Q
R
--
D
VLA
G
R
Q
P
D
I
Q
V
N
VD
A
TRM
S
Q
A
F
T
GN
GYIQ
N
I
INGEV
N
SFVA
R
YR-
-
D
NSE
P
LV
SL
ETR
M
R
F
NPNLD
PA
WF
-
-
G
G
V
M
AII
NN
I
TM
LAI
VLT
G
SAL
I
RERE
H
GTV
EH
LLV
M
P
I
T
PF
EI
M
M
A
K
V
WSM
G
L
V
V
L
V
V
SG
L
SLV
LM
VK---G
V
L
GVP
IE
GS
IP
LF
M
L
GVA
L
S
LFAT
T
S
I
G
IFMG
T
IAR
S
M
P
Q
L
GL
L
V
I
L
V
-
LLP
L
QM
LSG
GST
P
R
ESMP
---
Q
M
VQD
IMLTM
PT
T
HF
VS
L
AQ
A
I
LY
R
G
A
G
F
E
IVW
PQ
F
L
T
L
M
A
IGGAFFTIA
L
LRFRKTI
fig|656443.3.peg.4385
Escherichia coli TA271 (13-370/374)
KEL
R
SLL
G
D
-
--------KA
M
L
T
LIVF
S
F
TV
SV
YSSATVTPG
S
L
N
L
A
P
IAI
A
D
M
DQ
SQL
S
NRI
V
NS
F
Y
R
PWF
L
--P
P
E
M
I
T
A
DEMD
AG
LDAG
RY
T
F
AI
N
IPPNF
Q
R
--
D
VLA
G
R
Q
P
D
I
Q
V
N
VD
A
TRM
S
Q
A
F
T
GN
GYIQ
N
I
INGEV
N
SFVA
R
YR-
-
D
NSE
P
LV
SL
ETR
M
R
F
NPNLD
PA
WF
-
-
G
G
V
M
AII
NN
I
TM
LAI
VLT
G
SAL
I
RERE
H
GTV
EH
LLV
M
P
I
T
PF
EI
M
M
A
K
V
WSM
G
L
V
V
L
V
V
SG
L
SLV
LM
VK---G
V
L
GVP
IE
GS
IP
LF
M
L
GVA
L
S
LFAT
T
S
I
G
IFMG
T
IAR
S
M
P
Q
L
GL
L
V
I
L
V
-
LLP
L
QM
LSG
GST
P
R
ESMP
---
Q
M
VQD
IMLTM
PT
T
HF
VS
L
AQ
A
I
LY
R
G
A
G
F
E
IVW
PQ
F
L
T
L
M
A
IGGAFFTIA
L
LRFRKTI
fig|656444.3.peg.4756
Escherichia coli TA280 (13-370/374)
KEL
R
SLL
G
D
-
--------KA
M
L
T
LIVF
S
F
TV
SV
YSSATVTPG
S
L
N
L
A
P
IAI
A
D
M
DQ
SQL
S
NRI
V
NS
F
Y
R
PWF
L
--P
P
E
M
I
T
A
DEMD
AG
LDAG
RY
T
F
AI
N
IPPNF
Q
R
--
D
VLA
G
R
Q
P
D
I
Q
V
N
VD
A
TRM
S
Q
A
F
T
GN
GYIQ
N
I
INGEV
N
SFVA
R
YR-
-
D
NSE
P
LV
SL
ETR
M
R
F
NPNLD
PA
WF
-
-
G
G
V
M
AII
NN
I
TM
LAI
VLT
G
SAL
I
RERE
H
GTV
EH
LLV
M
P
I
T
PF
EI
M
M
A
K
V
WSM
G
L
V
V
L
V
V
SG
L
SLV
LM
VK---G
V
L
GVP
IE
GS
IP
LF
M
L
GVA
L
S
LFAT
T
S
I
G
IFMG
T
IAR
S
M
P
Q
L
GL
L
V
I
L
V
-
LLP
L
QM
LSG
GST
P
R
ESMP
---
Q
M
VQD
IMLTM
PT
T
HF
VS
L
AQ
A
I
LY
R
G
A
G
F
E
IVW
PQ
F
L
T
L
M
A
IGGAFFTIA
L
LRFRKTI
fig|869729.3.peg.3756
Escherichia coli UM146 (13-370/374)
KEL
R
SLL
G
D
-
--------KA
M
L
T
LIVF
S
F
TV
SV
YSSATVTPG
S
L
N
L
A
P
IAI
A
D
M
DQ
SQL
S
NRI
V
NS
F
Y
R
PWF
L
--P
P
E
M
I
T
A
DEMD
AG
LDAG
RY
T
F
AI
N
IPPNF
Q
R
--
D
VLA
G
R
Q
P
D
I
Q
V
N
VD
A
TRM
S
Q
A
F
T
GN
GYIQ
N
I
INGEV
N
SFVA
R
YR-
-
D
NSE
P
LV
SL
ETR
M
R
F
NPNLD
PA
WF
-
-
G
G
V
M
AII
NN
I
TM
LAI
VLT
G
SAL
I
RERE
H
GTV
EH
LLV
M
P
I
T
PF
EI
M
M
A
K
V
WSM
G
L
V
V
L
V
V
SG
L
SLV
LM
VK---G
V
L
GVP
IE
GS
IP
LF
M
L
GVA
L
S
LFAT
T
S
I
G
IFMG
T
IAR
S
M
P
Q
L
GL
L
V
I
L
V
-
LLP
L
QM
LSG
GST
P
R
ESMP
---
Q
M
VQD
IMLTM
PT
T
HF
VS
L
AQ
A
I
LY
R
G
A
G
F
E
IVW
PQ
F
L
T
L
M
A
IGGAFFTIA
L
LRFRKTI
fig|364106.7.peg.3921
Escherichia coli UTI89 (13-370/374)
KEL
R
SLL
G
D
-
--------KA
M
L
T
LIVF
S
F
TV
SV
YSSATVTPG
S
L
N
L
A
P
IAI
A
D
M
DQ
SQL
S
NRI
V
NS
F
Y
R
PWF
L
--P
P
E
M
I
T
A
DEMD
AG
LDAG
RY
T
F
AI
N
IPPNF
Q
R
--
D
VLA
G
R
Q
P
D
I
Q
V
N
VD
A
TRM
S
Q
A
F
T
GN
GYIQ
N
I
INGEV
N
SFVA
R
YR-
-
D
NSE
P
LV
SL
ETR
M
R
F
NPNLD
PA
WF
-
-
G
G
V
M
AII
NN
I
TM
LAI
VLT
G
SAL
I
RERE
H
GTV
EH
LLV
M
P
I
T
PF
EI
M
M
A
K
V
WSM
G
L
V
V
L
V
V
SG
L
SLV
LM
VK---G
V
L
GVP
IE
GS
IP
LF
M
L
GVA
L
S
LFAT
T
S
I
G
IFMG
T
IAR
S
M
P
Q
L
GL
L
V
I
L
V
-
LLP
L
QM
LSG
GST
P
R
ESMP
---
Q
M
VQD
IMLTM
PT
T
HF
VS
L
AQ
A
I
LY
R
G
A
G
F
E
IVW
PQ
F
L
T
L
M
A
IGGAFFTIA
L
LRFRKTI
fig|364106.8.peg.3922
Escherichia coli UTI89 (13-370/374)
KEL
R
SLL
G
D
-
--------KA
M
L
T
LIVF
S
F
TV
SV
YSSATVTPG
S
L
N
L
A
P
IAI
A
D
M
DQ
SQL
S
NRI
V
NS
F
Y
R
PWF
L
--P
P
E
M
I
T
A
DEMD
AG
LDAG
RY
T
F
AI
N
IPPNF
Q
R
--
D
VLA
G
R
Q
P
D
I
Q
V
N
VD
A
TRM
S
Q
A
F
T
GN
GYIQ
N
I
INGEV
N
SFVA
R
YR-
-
D
NSE
P
LV
SL
ETR
M
R
F
NPNLD
PA
WF
-
-
G
G
V
M
AII
NN
I
TM
LAI
VLT
G
SAL
I
RERE
H
GTV
EH
LLV
M
P
I
T
PF
EI
M
M
A
K
V
WSM
G
L
V
V
L
V
V
SG
L
SLV
LM
VK---G
V
L
GVP
IE
GS
IP
LF
M
L
GVA
L
S
LFAT
T
S
I
G
IFMG
T
IAR
S
M
P
Q
L
GL
L
V
I
L
V
-
LLP
L
QM
LSG
GST
P
R
ESMP
---
Q
M
VQD
IMLTM
PT
T
HF
VS
L
AQ
A
I
LY
R
G
A
G
F
E
IVW
PQ
F
L
T
L
M
A
IGGAFFTIA
L
LRFRKTI
fig|566546.3.peg.1986
Escherichia coli W (13-370/374)
KEL
R
SLL
G
D
-
--------KA
M
L
T
LIVF
S
F
TV
SV
YSSATVTPG
S
L
N
L
A
P
IAI
A
D
M
DQ
SQL
S
NRI
V
NS
F
Y
R
PWF
L
--P
P
E
M
I
T
A
DEMD
AG
LDAG
RY
T
F
AI
N
IPPNF
Q
R
--
D
VLA
G
R
Q
P
D
I
Q
V
N
VD
A
TRM
S
Q
A
F
T
GN
GYIQ
N
I
INGEV
N
SFVA
R
YR-
-
D
NSE
P
LV
SL
ETR
M
R
F
NPNLD
PA
WF
-
-
G
G
V
M
AII
NN
I
TM
LAI
VLT
G
SAL
I
RERE
H
GTV
EH
LLV
M
P
I
T
PF
EI
M
M
A
K
V
WSM
G
L
V
V
L
V
V
SG
L
SLV
LM
VK---G
V
L
GVP
IE
GS
IP
LF
M
L
GVA
L
S
LFAT
T
S
I
G
IFMG
T
IAR
S
M
P
Q
L
GL
L
V
I
L
V
-
LLP
L
QM
LSG
GST
P
R
ESMP
---
Q
M
VQD
IMLTM
PT
T
HF
VS
L
AQ
A
I
LY
R
G
A
G
F
E
IVW
PQ
F
L
T
L
M
A
IGGAFFTIA
L
LRFRKTI
fig|566546.4.peg.3700
Escherichia coli W (13-370/374)
KEL
R
SLL
G
D
-
--------KA
M
L
T
LIVF
S
F
TV
SV
YSSATVTPG
S
L
N
L
A
P
IAI
A
D
M
DQ
SQL
S
NRI
V
NS
F
Y
R
PWF
L
--P
P
E
M
I
T
A
DEMD
AG
LDAG
RY
T
F
AI
N
IPPNF
Q
R
--
D
VLA
G
R
Q
P
D
I
Q
V
N
VD
A
TRM
S
Q
A
F
T
GN
GYIQ
N
I
INGEV
N
SFVA
R
YR-
-
D
NSE
P
LV
SL
ETR
M
R
F
NPNLD
PA
WF
-
-
G
G
V
M
AII
NN
I
TM
LAI
VLT
G
SAL
I
RERE
H
GTV
EH
LLV
M
P
I
T
PF
EI
M
M
A
K
V
WSM
G
L
V
V
L
V
V
SG
L
SLV
LM
VK---G
V
L
GVP
IE
GS
IP
LF
M
L
GVA
L
S
LFAT
T
S
I
G
IFMG
T
IAR
S
M
P
Q
L
GL
L
V
I
L
V
-
LLP
L
QM
LSG
GST
P
R
ESMP
---
Q
M
VQD
IMLTM
PT
T
HF
VS
L
AQ
A
I
LY
R
G
A
G
F
E
IVW
PQ
F
L
T
L
M
A
IGGAFFTIA
L
LRFRKTI
fig|562.376.peg.2770
Escherichia coli WV_060327 (13-370/374)
KEL
R
SLL
G
D
-
--------KA
M
L
T
LIVF
S
F
TV
SV
YSSATVTPG
S
L
N
L
A
P
IAI
A
D
M
DQ
SQL
S
NRI
V
NS
F
Y
R
PWF
L
--P
P
E
M
I
T
A
DEMD
AG
LDAG
RY
T
F
AI
N
IPPNF
Q
R
--
D
VLA
G
R
Q
P
D
I
Q
V
N
VD
A
TRM
S
Q
A
F
T
GN
GYIQ
N
I
INGEV
N
SFVA
R
YR-
-
D
NSE
P
LV
SL
ETR
M
R
F
NPNLD
PA
WF
-
-
G
G
V
M
AII
NN
I
TM
LAI
VLT
G
SAL
I
RERE
H
GTV
EH
LLV
M
P
I
T
PF
EI
M
M
A
K
V
WSM
G
L
V
V
L
V
V
SG
L
SLV
LM
VK---G
V
L
GVP
IE
GS
IP
LF
M
L
GVA
L
S
LFAT
T
S
I
G
IFMG
T
IAR
S
M
P
Q
L
GL
L
V
I
L
V
-
LLP
L
QM
LSG
GST
P
R
ESMP
---
Q
M
VQD
IMLTM
PT
T
HF
VS
L
AQ
A
I
LY
R
G
A
G
F
E
IVW
PQ
F
L
T
L
M
A
IGGAFFTIA
L
LRFRKTI
fig|656437.3.peg.3908
Escherichia coli TA143 (13-370/374)
KEL
R
SLL
G
D
-
--------KA
M
L
T
LIVF
S
F
TV
SV
YSSATVTPG
S
L
N
L
A
P
IAI
A
D
M
DQ
SQL
S
NRI
V
NS
F
Y
R
PWF
L
--P
P
E
M
I
T
A
DEMD
AG
LDAG
RY
T
F
AI
N
IPPNF
Q
R
--
D
VLA
G
R
Q
P
D
I
Q
V
N
VD
A
TRM
S
Q
A
F
T
GN
GYIQ
N
I
INGEV
N
SFVA
R
YR-
-
D
NSE
P
LV
SL
ETR
M
R
F
NPNLD
PA
WF
-
-
G
G
V
M
AII
NN
I
TM
LAI
VLT
G
SAL
I
RERE
H
GTV
EH
LLV
M
P
I
T
PF
EI
M
M
A
K
V
WSM
G
W
V
V
L
V
V
SG
L
SLV
LM
VK---G
V
L
GVP
IE
GS
IP
LF
M
L
GVA
L
S
LFAT
T
S
I
G
IFMG
T
IAR
S
M
P
Q
L
GL
L
V
I
L
V
-
LLP
L
QM
LSG
GST
P
R
ESMP
---
Q
M
VQD
IMLTM
PT
T
HF
VS
L
AQ
A
I
LY
R
G
A
G
F
E
IVW
PQ
F
L
T
L
M
A
IGGAFFTIA
L
LRFRKTI
fig|670897.3.peg.3873
Escherichia coli 2362-75 (13-370/374)
KEL
R
SLL
G
D
-
--------KA
M
L
T
LIVF
S
F
TV
SV
YSSATVTPG
S
L
N
L
A
P
IAI
A
D
M
DQ
SQL
S
NRI
V
NS
F
Y
R
PWF
L
--P
P
E
M
I
T
A
DEMD
AG
LDAG
RY
T
F
AI
N
IPPNF
Q
R
--
D
VLA
G
R
Q
P
D
I
Q
V
N
VD
A
TRM
S
Q
A
F
T
GN
GYIQ
N
I
INGEV
N
SFVA
R
YR-
-
D
NSE
P
LV
SL
ETR
M
R
F
NPNLD
PA
WF
-
-
G
G
V
M
AII
NN
I
TM
LAI
VLT
G
SAL
I
RERE
H
GTV
EH
LLV
M
P
I
T
PF
EI
M
M
A
K
V
WSM
G
L
V
V
L
V
V
SG
L
SLV
LM
VK---G
V
L
GVP
IE
GS
IP
LF
M
L
GVA
L
S
LFAT
T
S
I
G
IFMG
T
IAR
S
M
P
Q
L
GL
L
V
I
L
V
-
LLP
L
QM
LSG
GST
P
R
ESMP
---
Q
M
VQD
IMLTM
PT
T
HF
VS
L
V
Q
A
I
LY
R
G
A
G
F
E
IVW
PQ
F
L
T
L
M
A
IGGAFFTIA
L
LRFRKTI
fig|362663.8.peg.3610
Escherichia coli 536 (13-370/374)
KEL
R
SLL
G
D
-
--------KA
M
L
T
LIVF
S
F
TV
SV
YSSATVTPG
S
L
N
L
A
P
IAI
A
D
M
DQ
SQL
S
NRI
V
NS
F
Y
R
PWF
L
--P
P
E
M
I
T
A
DEMD
AG
LDAG
RY
T
F
AI
N
IPPNF
Q
R
--
D
VLA
G
R
Q
P
D
I
Q
V
N
VD
A
TRM
S
Q
A
F
T
GN
GYIQ
N
I
INGEV
N
SFVA
R
YR-
-
D
NSE
P
LV
SL
ETR
M
R
F
NPNLD
PA
WF
-
-
G
G
V
M
AII
NN
I
TM
LAI
VLT
G
SAL
I
RERE
H
GTV
EH
LLV
M
P
I
T
PF
EI
M
M
A
K
V
WSM
G
L
V
V
L
V
V
SG
L
SLV
LM
VK---G
V
L
GVP
IE
GS
IP
LF
M
L
GVA
L
S
LFAT
T
S
I
G
IFMG
T
IAR
S
M
P
Q
L
GL
L
V
I
L
V
-
LLP
L
QM
LSG
GST
P
R
ESMP
---
Q
M
VQD
IMLTM
PT
T
HF
VS
L
AQ
A
I
LY
R
G
A
G
F
E
IVW
PQ
F
L
T
L
M
A
IGGAFFTIA
Q
LRFRKTI
fig|362663.9.peg.3622
Escherichia coli 536 (13-370/374)
KEL
R
SLL
G
D
-
--------KA
M
L
T
LIVF
S
F
TV
SV
YSSATVTPG
S
L
N
L
A
P
IAI
A
D
M
DQ
SQL
S
NRI
V
NS
F
Y
R
PWF
L
--P
P
E
M
I
T
A
DEMD
AG
LDAG
RY
T
F
AI
N
IPPNF
Q
R
--
D
VLA
G
R
Q
P
D
I
Q
V
N
VD
A
TRM
S
Q
A
F
T
GN
GYIQ
N
I
INGEV
N
SFVA
R
YR-
-
D
NSE
P
LV
SL
ETR
M
R
F
NPNLD
PA
WF
-
-
G
G
V
M
AII
NN
I
TM
LAI
VLT
G
SAL
I
RERE
H
GTV
EH
LLV
M
P
I
T
PF
EI
M
M
A
K
V
WSM
G
L
V
V
L
V
V
SG
L
SLV
LM
VK---G
V
L
GVP
IE
GS
IP
LF
M
L
GVA
L
S
LFAT
T
S
I
G
IFMG
T
IAR
S
M
P
Q
L
GL
L
V
I
L
V
-
LLP
L
QM
LSG
GST
P
R
ESMP
---
Q
M
VQD
IMLTM
PT
T
HF
VS
L
AQ
A
I
LY
R
G
A
G
F
E
IVW
PQ
F
L
T
L
M
A
IGGAFFTIA
Q
LRFRKTI
fig|340197.3.peg.685
Escherichia coli F11 (13-370/374)
KEL
R
SLL
G
D
-
--------KA
M
L
T
LIVF
S
F
TV
SV
YSSATVTPG
S
L
N
L
A
P
IAI
A
D
M
DQ
SQL
S
NRI
V
NS
F
Y
R
PWF
L
--P
P
E
M
I
T
A
DEMD
AG
LDAG
RY
T
F
AI
N
IPPNF
Q
R
--
D
VLA
G
R
Q
P
D
I
Q
V
N
VD
A
TRM
S
Q
A
F
T
GN
GYIQ
N
I
INGEV
N
SFVA
R
YR-
-
D
NSE
P
LV
SL
ETR
M
R
F
NPNLD
PA
WF
-
-
G
G
V
M
AII
NN
I
TM
LAI
VLT
G
SAL
I
RERE
H
GTV
EH
LLV
M
P
I
T
PF
EI
M
M
A
K
V
WSM
G
L
V
V
L
V
V
SG
L
SLV
LM
VK---G
V
L
GVP
IE
GS
IP
LF
M
L
GVA
L
S
LFAT
T
S
I
G
IFMG
T
IAR
S
M
P
Q
L
GL
L
V
I
L
V
-
LLP
L
QM
LSG
GST
P
R
ESMP
---
Q
M
VQD
IMLTM
PT
T
HF
VS
L
AQ
A
I
LY
R
G
A
G
F
E
IVW
PQ
F
L
T
L
M
A
IGGAFFTIA
Q
LRFRKTI
fig|340197.5.peg.711
Escherichia coli F11 (13-370/374)
KEL
R
SLL
G
D
-
--------KA
M
L
T
LIVF
S
F
TV
SV
YSSATVTPG
S
L
N
L
A
P
IAI
A
D
M
DQ
SQL
S
NRI
V
NS
F
Y
R
PWF
L
--P
P
E
M
I
T
A
DEMD
AG
LDAG
RY
T
F
AI
N
IPPNF
Q
R
--
D
VLA
G
R
Q
P
D
I
Q
V
N
VD
A
TRM
S
Q
A
F
T
GN
GYIQ
N
I
INGEV
N
SFVA
R
YR-
-
D
NSE
P
LV
SL
ETR
M
R
F
NPNLD
PA
WF
-
-
G
G
V
M
AII
NN
I
TM
LAI
VLT
G
SAL
I
RERE
H
GTV
EH
LLV
M
P
I
T
PF
EI
M
M
A
K
V
WSM
G
L
V
V
L
V
V
SG
L
SLV
LM
VK---G
V
L
GVP
IE
GS
IP
LF
M
L
GVA
L
S
LFAT
T
S
I
G
IFMG
T
IAR
S
M
P
Q
L
GL
L
V
I
L
V
-
LLP
L
QM
LSG
GST
P
R
ESMP
---
Q
M
VQD
IMLTM
PT
T
HF
VS
L
AQ
A
I
LY
R
G
A
G
F
E
IVW
PQ
F
L
T
L
M
A
IGGAFFTIA
Q
LRFRKTI
fig|749550.3.peg.3096
Escherichia coli MS 200-1 (13-370/374)
KEL
R
SLL
G
D
-
--------KA
M
L
T
LIVF
S
F
TV
SV
YSSATVTPG
S
L
N
L
A
P
IAI
A
D
M
DQ
SQL
S
NRI
V
NS
F
Y
R
PWF
L
--P
P
E
M
I
T
A
DEMD
AG
LDAG
RY
T
F
AI
N
IPPNF
Q
R
--
D
VLA
G
R
Q
P
D
I
Q
V
N
VD
A
TRM
S
Q
A
F
T
GN
GYIQ
N
I
INGEV
N
SFVA
R
YR-
-
D
NSE
P
LV
SL
ETR
M
R
F
NPNLD
PA
WF
-
-
G
G
V
M
AII
NN
I
TM
LAI
VLT
G
SAL
I
RERE
H
GTV
EH
LLV
M
P
I
T
PF
EI
M
M
A
K
V
WSM
G
L
V
V
L
V
V
SG
L
SLV
LM
VK---G
V
L
GVP
IE
GS
IP
LF
M
L
GVA
L
S
LFAT
T
S
I
G
IFMG
T
IAR
S
M
P
Q
L
GL
L
V
I
L
V
-
LLP
L
QM
LSG
GST
P
R
ESMP
---
Q
M
VQD
IMLTM
PT
T
HF
VS
L
AQ
A
I
LY
R
G
A
G
F
E
IVW
PQ
F
L
T
L
M
A
IGGAFFTIA
Q
LRFRKTI
fig|585397.7.peg.4146
Escherichia coli ED1a (13-370/374)
KEL
R
SLL
G
D
-
--------KA
M
L
T
LIVF
S
F
TV
SV
YSSATVTPG
S
L
N
L
A
P
IAI
A
D
M
DQ
SQL
S
NRI
V
NS
F
Y
R
PWF
L
--P
P
E
M
I
T
A
DEMD
AG
LDAG
RY
T
F
AI
N
IPPNF
Q
R
--
D
VLA
G
R
Q
P
D
I
Q
V
N
VD
A
TRM
S
Q
A
F
T
GN
GYIQ
N
I
INGEV
N
SFVA
R
YR-
-
D
NSE
P
LV
SL
ETR
M
R
F
NPNLD
PA
WF
-
-
G
G
V
M
AII
NN
I
TM
LAI
VLT
G
SAL
I
RERE
H
GTV
EH
LLV
M
P
I
T
PF
EI
M
M
A
K
V
WSM
G
L
V
V
L
V
V
SG
L
SLV
LM
VK---G
V
L
GVP
IE
GS
IP
LF
M
L
GVA
L
S
LFAT
T
S
I
G
IFMG
T
IAR
S
M
P
Q
L
GL
L
V
I
L
V
-
LLP
L
QM
LSG
GST
P
R
ESMP
---
Q
M
VQD
IMLTM
PT
T
HF
VS
L
AQ
A
I
LY
R
G
A
G
F
E
IVW
PQ
F
L
T
L
I
A
IGGAFFTIA
L
LRFRKTI
fig|585397.9.peg.4142
Escherichia coli ED1a (13-370/374)
KEL
R
SLL
G
D
-
--------KA
M
L
T
LIVF
S
F
TV
SV
YSSATVTPG
S
L
N
L
A
P
IAI
A
D
M
DQ
SQL
S
NRI
V
NS
F
Y
R
PWF
L
--P
P
E
M
I
T
A
DEMD
AG
LDAG
RY
T
F
AI
N
IPPNF
Q
R
--
D
VLA
G
R
Q
P
D
I
Q
V
N
VD
A
TRM
S
Q
A
F
T
GN
GYIQ
N
I
INGEV
N
SFVA
R
YR-
-
D
NSE
P
LV
SL
ETR
M
R
F
NPNLD
PA
WF
-
-
G
G
V
M
AII
NN
I
TM
LAI
VLT
G
SAL
I
RERE
H
GTV
EH
LLV
M
P
I
T
PF
EI
M
M
A
K
V
WSM
G
L
V
V
L
V
V
SG
L
SLV
LM
VK---G
V
L
GVP
IE
GS
IP
LF
M
L
GVA
L
S
LFAT
T
S
I
G
IFMG
T
IAR
S
M
P
Q
L
GL
L
V
I
L
V
-
LLP
L
QM
LSG
GST
P
R
ESMP
---
Q
M
VQD
IMLTM
PT
T
HF
VS
L
AQ
A
I
LY
R
G
A
G
F
E
IVW
PQ
F
L
T
L
I
A
IGGAFFTIA
L
LRFRKTI
fig|656417.3.peg.4344
Escherichia coli M605 (13-370/374)
KEL
R
SLL
G
D
-
--------KA
M
L
T
LIVF
S
F
TV
SV
YSSATVTPG
S
L
N
L
A
P
IAI
A
D
M
DQ
SQL
S
NRI
V
NS
F
Y
R
PWF
L
--P
P
E
M
I
T
A
DEMD
AG
LDAG
RY
T
F
AI
N
IPPNF
Q
R
--
D
VLA
G
R
Q
P
D
I
Q
V
N
VD
A
TRM
S
Q
A
F
T
GN
GYIQ
N
I
INGEV
N
SFVA
R
YR-
-
D
NSE
P
LV
SL
ETR
M
R
F
NPNLD
PA
WF
-
-
G
G
V
M
AII
NN
I
TM
LAI
VLT
G
SAL
I
RERE
H
GTV
EH
LLV
M
P
I
T
PF
EI
M
M
A
K
V
WSM
G
L
V
V
L
V
V
SG
L
SLV
LM
VK---G
V
L
GVP
IE
GS
IP
LF
M
L
GVA
L
S
LFAT
T
S
I
G
IFMG
T
IAR
S
M
P
Q
L
GL
L
V
I
L
V
-
LLP
L
QM
LSG
GST
P
R
ESMP
---
Q
M
VQD
IMLTM
PT
T
HF
VS
L
AQ
A
I
LY
R
G
A
G
F
E
IVW
PQ
F
L
T
L
I
A
IGGAFFTIA
L
LRFRKTI
fig|431946.3.peg.3449
Escherichia coli SE15 (13-370/374)
KEL
R
SLL
G
D
-
--------KA
M
L
T
LIVF
S
F
TV
SV
YSSATVTPG
S
L
N
L
A
P
IAI
A
D
M
DQ
SQL
S
NRI
V
NS
F
Y
R
PWF
L
--P
P
E
M
I
T
A
DEMD
AG
LDAG
RY
T
F
AI
N
IPPNF
Q
R
--
D
VLA
G
R
Q
P
D
I
Q
V
N
VD
A
TRM
S
Q
A
F
T
GN
GYIQ
N
I
INGEV
N
SFVA
R
YR-
-
D
NSE
P
LV
SL
ETR
M
R
F
NPNLD
PA
WF
-
-
G
G
V
M
AII
NN
I
TM
LAI
VLT
G
SAL
I
RERE
H
GTV
EH
LLV
M
P
I
T
PF
EI
M
M
A
K
V
WSM
G
L
V
V
L
V
V
SG
L
SLV
LM
VK---G
V
L
GVP
IE
GS
IP
LF
M
L
GVA
L
S
LFAT
T
S
I
G
IFMG
T
IAR
S
M
P
Q
L
GL
L
V
I
L
V
-
LLP
L
QM
LSG
GST
P
R
ESMP
---
Q
M
VQD
IMLTM
PT
T
HF
VS
L
AQ
A
I
LY
R
G
A
G
F
E
IVW
PQ
F
L
T
L
I
A
IGGAFFTIA
L
LRFRKTI
fig|409438.11.peg.3920
Escherichia coli SE11 (13-370/374)
KEL
R
SLL
G
D
-
--------KA
M
L
T
LIVF
S
F
TV
SV
YSSATVTPG
S
L
N
L
A
P
IAI
A
D
M
DQ
SQL
S
NRI
V
NS
F
Y
R
PWF
L
--P
P
E
M
I
T
A
DEMD
AG
LDAG
RY
T
F
AI
N
IPPNF
Q
R
--
D
VLA
G
R
Q
P
D
I
Q
V
N
VD
A
TRM
S
Q
A
F
T
GN
GYIQ
N
I
INGEV
N
SFVA
R
YR-
-
D
NSE
P
LV
SL
ETR
M
R
F
NPNLD
PA
WF
-
-
G
G
V
M
AII
NN
I
TM
LAI
VLT
G
SAL
I
RERE
H
GTV
EH
LLV
M
P
I
T
PF
EI
M
M
A
K
V
WSM
G
L
V
V
L
V
V
SG
L
SLV
LM
VK---G
V
L
GVP
IE
GS
VP
LF
M
L
GVA
L
S
LFAT
T
S
I
G
IFMG
T
IAR
S
M
P
Q
L
GL
L
V
I
L
V
-
LLP
L
QM
LSG
GST
P
R
ESMP
---
Q
M
VQD
IMLTM
PT
T
HF
VS
L
AQ
A
I
LY
R
G
A
G
F
E
IVW
PQ
F
L
T
L
M
A
IGGAFFTIA
L
LRFRKTI
fig|656393.3.peg.4543
Escherichia coli H299 (13-370/374)
KEL
R
SLL
G
D
-
--------KA
M
L
T
LIVF
S
F
TV
SV
YSSATVTPG
S
L
N
L
A
P
IAI
A
D
M
DQ
SQL
S
NRI
V
NS
F
Y
R
PWF
L
--P
P
E
M
I
T
A
DEMD
AG
LDAG
RY
T
F
AI
N
IPPNF
Q
R
--
D
VLA
G
R
Q
P
D
I
Q
V
N
VD
A
TRM
S
Q
A
F
T
GN
GYIQ
N
I
INGEV
N
SFVA
R
YR-
-
D
NSE
P
LV
SL
ETR
M
R
F
NPNLD
PA
WF
-
-
G
G
V
M
AII
NN
I
TM
LAI
VLT
G
SAL
I
RERE
H
GTV
EH
LLV
M
P
I
T
PF
EI
M
M
A
K
V
WSM
G
L
V
V
L
V
V
SG
L
SLV
LM
VK---G
V
L
GVP
IE
GS
IP
LF
M
L
GVA
L
S
LFAT
T
S
I
G
IFMG
T
IAR
S
M
P
Q
L
GL
L
V
I
L
V
-
LLP
L
QM
LSG
GST
P
R
ESMP
---
Q
T
VQD
IMLTM
PT
T
HF
VS
L
AQ
A
I
LY
R
G
A
G
F
E
IVW
PQ
F
L
T
L
M
A
IGGAFFTIA
L
LRFRKTI
fig|340186.3.peg.4987
Escherichia coli E110019 (14-371/375)
KEL
R
SLL
G
D
-
--------KA
M
L
T
LIVF
S
F
TV
SV
YSSATVTPG
S
L
N
L
A
P
IAI
A
D
M
DQ
SQL
S
NRI
V
NS
F
Y
R
PWF
L
--P
P
E
M
I
T
A
DEMD
AG
LDAG
RY
T
F
AI
N
IPPNF
Q
R
--
D
VLA
G
R
Q
P
D
I
Q
V
N
VD
A
TRM
S
Q
A
F
T
GN
GYIQ
N
I
INGEV
N
SFVA
R
YR-
-
D
NSE
P
LV
SL
ETR
M
R
F
NPNLD
PA
WF
-
-
G
G
V
M
AII
NN
I
TM
LAI
VLT
G
SAL
I
RERE
H
GTV
EH
LLV
M
P
I
T
PF
EI
M
M
A
K
I
WSM
G
L
V
V
L
V
V
SG
L
SLV
LM
VK---G
V
L
GVP
IE
GS
IP
LF
M
L
GVA
L
S
LFAT
T
S
I
G
IFMG
T
IAR
S
M
P
Q
L
GL
L
V
I
L
V
-
LLP
L
QM
LSG
GST
P
R
ESMP
---
Q
M
VQD
IMLTM
PT
T
HF
VS
L
AQ
A
I
LY
R
G
A
G
F
E
IVW
PQ
F
L
T
L
M
A
IGGAFFTIA
L
LRFRKTI
fig|6666666.5357.peg.1870
Escherichia coli TY-2482 (13-370/374)
KEL
R
SLL
G
D
-
--------KA
M
L
T
LIVF
S
F
TV
SV
YSSATVTPG
S
L
N
L
A
P
IAI
A
D
M
DQ
SQL
S
NRI
V
NS
F
Y
R
PWF
L
--P
P
E
M
I
T
A
DEMD
AG
LDAG
RY
T
F
AI
N
IPPNF
Q
R
--
D
VLA
G
R
Q
P
D
I
Q
V
N
VD
A
TRM
S
Q
A
F
T
GN
GYIQ
N
I
INGEV
N
SFVA
R
YR-
-
D
NSE
P
LV
SL
ETR
M
R
F
NPNLD
PA
WF
-
-
G
G
V
M
AII
NN
I
TM
LAI
VLT
G
SAL
I
RERE
H
GTV
EH
LLV
M
P
I
T
PF
EI
M
M
A
K
I
WSM
G
L
V
V
L
V
V
SG
L
SLV
LM
VK---G
V
L
GVP
IE
GS
IP
LF
M
L
GVA
L
S
LFAT
T
S
I
G
IFMG
T
IAR
S
M
P
Q
L
GL
L
V
I
L
V
-
LLP
L
QM
LSG
GST
P
R
ESMP
---
Q
M
VQD
IMLTM
PT
T
HF
VS
L
AQ
A
I
LY
R
G
A
G
F
E
IVW
PQ
F
L
T
L
M
A
IGGAFFTIA
L
LRFRKTI
fig|358709.5.peg.333
Escherichia coli 101-1 (13-370/374)
KEL
R
SLL
G
D
-
--------KA
M
L
T
LIVF
S
F
TV
SV
YSSATVTPG
S
L
N
L
A
P
IAI
A
D
M
DQ
SQL
S
NRI
V
NS
F
Y
R
PWF
L
--P
P
E
M
I
T
A
DEMD
AG
LDAG
RY
T
F
AI
N
IPPNF
Q
R
--
D
VLA
G
R
Q
P
D
I
Q
V
N
VD
A
TRM
S
Q
A
F
T
GN
GYIQ
N
I
INGEV
N
SFVA
R
YR-
-
D
NSE
P
LV
SL
ETR
M
R
F
NPNLD
PA
WF
-
-
G
G
V
M
AII
NN
I
TM
LAI
VLT
G
SAL
I
RERE
H
GTV
EH
LLV
M
P
I
T
PF
EI
M
M
A
K
I
WSM
G
L
V
V
L
V
V
SG
L
SLV
LM
VK---G
V
L
GVP
IE
GS
IP
LF
M
L
GVA
L
S
LFAT
T
S
I
G
IFMG
T
IAR
S
M
P
Q
L
GL
L
V
I
L
V
-
LLP
L
QM
LSG
GST
P
R
ESMP
---
Q
M
VQD
IMLTM
PT
T
HF
VS
L
AQ
A
I
LY
R
G
A
G
F
E
IVW
PQ
F
L
T
L
M
A
IGGAFFTIA
L
LRFRKTI
fig|344610.3.peg.120
Escherichia coli 53638 (13-370/374)
KEL
R
SLL
G
D
-
--------KA
M
L
T
LIVF
S
F
TV
SV
YSSATVTPG
S
L
N
L
A
P
IAI
A
D
M
DQ
SQL
S
NRI
V
NS
F
Y
R
PWF
L
--P
P
E
M
I
T
A
DEMD
AG
LDAG
RY
T
F
AI
N
IPPNF
Q
R
--
D
VLA
G
R
Q
P
D
I
Q
V
N
VD
A
TRM
S
Q
A
F
T
GN
GYIQ
N
I
INGEV
N
SFVA
R
YR-
-
D
NSE
P
LV
SL
ETR
M
R
F
NPNLD
PA
WF
-
-
G
G
V
M
AII
NN
I
TM
LAI
VLT
G
SAL
I
RERE
H
GTV
EH
LLV
M
P
I
T
PF
EI
M
M
A
K
I
WSM
G
L
V
V
L
V
V
SG
L
SLV
LM
VK---G
V
L
GVP
IE
GS
IP
LF
M
L
GVA
L
S
LFAT
T
S
I
G
IFMG
T
IAR
S
M
P
Q
L
GL
L
V
I
L
V
-
LLP
L
QM
LSG
GST
P
R
ESMP
---
Q
M
VQD
IMLTM
PT
T
HF
VS
L
AQ
A
I
LY
R
G
A
G
F
E
IVW
PQ
F
L
T
L
M
A
IGGAFFTIA
L
LRFRKTI
fig|344610.7.peg.2748
Escherichia coli 53638 (13-370/374)
KEL
R
SLL
G
D
-
--------KA
M
L
T
LIVF
S
F
TV
SV
YSSATVTPG
S
L
N
L
A
P
IAI
A
D
M
DQ
SQL
S
NRI
V
NS
F
Y
R
PWF
L
--P
P
E
M
I
T
A
DEMD
AG
LDAG
RY
T
F
AI
N
IPPNF
Q
R
--
D
VLA
G
R
Q
P
D
I
Q
V
N
VD
A
TRM
S
Q
A
F
T
GN
GYIQ
N
I
INGEV
N
SFVA
R
YR-
-
D
NSE
P
LV
SL
ETR
M
R
F
NPNLD
PA
WF
-
-
G
G
V
M
AII
NN
I
TM
LAI
VLT
G
SAL
I
RERE
H
GTV
EH
LLV
M
P
I
T
PF
EI
M
M
A
K
I
WSM
G
L
V
V
L
V
V
SG
L
SLV
LM
VK---G
V
L
GVP
IE
GS
IP
LF
M
L
GVA
L
S
LFAT
T
S
I
G
IFMG
T
IAR
S
M
P
Q
L
GL
L
V
I
L
V
-
LLP
L
QM
LSG
GST
P
R
ESMP
---
Q
M
VQD
IMLTM
PT
T
HF
VS
L
AQ
A
I
LY
R
G
A
G
F
E
IVW
PQ
F
L
T
L
M
A
IGGAFFTIA
L
LRFRKTI
fig|585055.6.peg.3922
Escherichia coli 55989 (13-370/374)
KEL
R
SLL
G
D
-
--------KA
M
L
T
LIVF
S
F
TV
SV
YSSATVTPG
S
L
N
L
A
P
IAI
A
D
M
DQ
SQL
S
NRI
V
NS
F
Y
R
PWF
L
--P
P
E
M
I
T
A
DEMD
AG
LDAG
RY
T
F
AI
N
IPPNF
Q
R
--
D
VLA
G
R
Q
P
D
I
Q
V
N
VD
A
TRM
S
Q
A
F
T
GN
GYIQ
N
I
INGEV
N
SFVA
R
YR-
-
D
NSE
P
LV
SL
ETR
M
R
F
NPNLD
PA
WF
-
-
G
G
V
M
AII
NN
I
TM
LAI
VLT
G
SAL
I
RERE
H
GTV
EH
LLV
M
P
I
T
PF
EI
M
M
A
K
I
WSM
G
L
V
V
L
V
V
SG
L
SLV
LM
VK---G
V
L
GVP
IE
GS
IP
LF
M
L
GVA
L
S
LFAT
T
S
I
G
IFMG
T
IAR
S
M
P
Q
L
GL
L
V
I
L
V
-
LLP
L
QM
LSG
GST
P
R
ESMP
---
Q
M
VQD
IMLTM
PT
T
HF
VS
L
AQ
A
I
LY
R
G
A
G
F
E
IVW
PQ
F
L
T
L
M
A
IGGAFFTIA
L
LRFRKTI
fig|585055.8.peg.3924
Escherichia coli 55989 (13-370/374)
KEL
R
SLL
G
D
-
--------KA
M
L
T
LIVF
S
F
TV
SV
YSSATVTPG
S
L
N
L
A
P
IAI
A
D
M
DQ
SQL
S
NRI
V
NS
F
Y
R
PWF
L
--P
P
E
M
I
T
A
DEMD
AG
LDAG
RY
T
F
AI
N
IPPNF
Q
R
--
D
VLA
G
R
Q
P
D
I
Q
V
N
VD
A
TRM
S
Q
A
F
T
GN
GYIQ
N
I
INGEV
N
SFVA
R
YR-
-
D
NSE
P
LV
SL
ETR
M
R
F
NPNLD
PA
WF
-
-
G
G
V
M
AII
NN
I
TM
LAI
VLT
G
SAL
I
RERE
H
GTV
EH
LLV
M
P
I
T
PF
EI
M
M
A
K
I
WSM
G
L
V
V
L
V
V
SG
L
SLV
LM
VK---G
V
L
GVP
IE
GS
IP
LF
M
L
GVA
L
S
LFAT
T
S
I
G
IFMG
T
IAR
S
M
P
Q
L
GL
L
V
I
L
V
-
LLP
L
QM
LSG
GST
P
R
ESMP
---
Q
M
VQD
IMLTM
PT
T
HF
VS
L
AQ
A
I
LY
R
G
A
G
F
E
IVW
PQ
F
L
T
L
M
A
IGGAFFTIA
L
LRFRKTI
fig|413997.3.peg.3492
Escherichia coli B str. REL606 (13-370/374)
KEL
R
SLL
G
D
-
--------KA
M
L
T
LIVF
S
F
TV
SV
YSSATVTPG
S
L
N
L
A
P
IAI
A
D
M
DQ
SQL
S
NRI
V
NS
F
Y
R
PWF
L
--P
P
E
M
I
T
A
DEMD
AG
LDAG
RY
T
F
AI
N
IPPNF
Q
R
--
D
VLA
G
R
Q
P
D
I
Q
V
N
VD
A
TRM
S
Q
A
F
T
GN
GYIQ
N
I
INGEV
N
SFVA
R
YR-
-
D
NSE
P
LV
SL
ETR
M
R
F
NPNLD
PA
WF
-
-
G
G
V
M
AII
NN
I
TM
LAI
VLT
G
SAL
I
RERE
H
GTV
EH
LLV
M
P
I
T
PF
EI
M
M
A
K
I
WSM
G
L
V
V
L
V
V
SG
L
SLV
LM
VK---G
V
L
GVP
IE
GS
IP
LF
M
L
GVA
L
S
LFAT
T
S
I
G
IFMG
T
IAR
S
M
P
Q
L
GL
L
V
I
L
V
-
LLP
L
QM
LSG
GST
P
R
ESMP
---
Q
M
VQD
IMLTM
PT
T
HF
VS
L
AQ
A
I
LY
R
G
A
G
F
E
IVW
PQ
F
L
T
L
M
A
IGGAFFTIA
L
LRFRKTI
fig|344601.3.peg.1323
Escherichia coli B171 (13-370/374)
KEL
R
SLL
G
D
-
--------KA
M
L
T
LIVF
S
F
TV
SV
YSSATVTPG
S
L
N
L
A
P
IAI
A
D
M
DQ
SQL
S
NRI
V
NS
F
Y
R
PWF
L
--P
P
E
M
I
T
A
DEMD
AG
LDAG
RY
T
F
AI
N
IPPNF
Q
R
--
D
VLA
G
R
Q
P
D
I
Q
V
N
VD
A
TRM
S
Q
A
F
T
GN
GYIQ
N
I
INGEV
N
SFVA
R
YR-
-
D
NSE
P
LV
SL
ETR
M
R
F
NPNLD
PA
WF
-
-
G
G
V
M
AII
NN
I
TM
LAI
VLT
G
SAL
I
RERE
H
GTV
EH
LLV
M
P
I
T
PF
EI
M
M
A
K
I
WSM
G
L
V
V
L
V
V
SG
L
SLV
LM
VK---G
V
L
GVP
IE
GS
IP
LF
M
L
GVA
L
S
LFAT
T
S
I
G
IFMG
T
IAR
S
M
P
Q
L
GL
L
V
I
L
V
-
LLP
L
QM
LSG
GST
P
R
ESMP
---
Q
M
VQD
IMLTM
PT
T
HF
VS
L
AQ
A
I
LY
R
G
A
G
F
E
IVW
PQ
F
L
T
L
M
A
IGGAFFTIA
L
LRFRKTI
fig|344601.5.peg.1391
Escherichia coli B171 (13-370/374)
KEL
R
SLL
G
D
-
--------KA
M
L
T
LIVF
S
F
TV
SV
YSSATVTPG
S
L
N
L
A
P
IAI
A
D
M
DQ
SQL
S
NRI
V
NS
F
Y
R
PWF
L
--P
P
E
M
I
T
A
DEMD
AG
LDAG
RY
T
F
AI
N
IPPNF
Q
R
--
D
VLA
G
R
Q
P
D
I
Q
V
N
VD
A
TRM
S
Q
A
F
T
GN
GYIQ
N
I
INGEV
N
SFVA
R
YR-
-
D
NSE
P
LV
SL
ETR
M
R
F
NPNLD
PA
WF
-
-
G
G
V
M
AII
NN
I
TM
LAI
VLT
G
SAL
I
RERE
H
GTV
EH
LLV
M
P
I
T
PF
EI
M
M
A
K
I
WSM
G
L
V
V
L
V
V
SG
L
SLV
LM
VK---G
V
L
GVP
IE
GS
IP
LF
M
L
GVA
L
S
LFAT
T
S
I
G
IFMG
T
IAR
S
M
P
Q
L
GL
L
V
I
L
V
-
LLP
L
QM
LSG
GST
P
R
ESMP
---
Q
M
VQD
IMLTM
PT
T
HF
VS
L
AQ
A
I
LY
R
G
A
G
F
E
IVW
PQ
F
L
T
L
M
A
IGGAFFTIA
L
LRFRKTI
fig|340184.3.peg.373
Escherichia coli B7A (13-370/374)
KEL
R
SLL
G
D
-
--------KA
M
L
T
LIVF
S
F
TV
SV
YSSATVTPG
S
L
N
L
A
P
IAI
A
D
M
DQ
SQL
S
NRI
V
NS
F
Y
R
PWF
L
--P
P
E
M
I
T
A
DEMD
AG
LDAG
RY
T
F
AI
N
IPPNF
Q
R
--
D
VLA
G
R
Q
P
D
I
Q
V
N
VD
A
TRM
S
Q
A
F
T
GN
GYIQ
N
I
INGEV
N
SFVA
R
YR-
-
D
NSE
P
LV
SL
ETR
M
R
F
NPNLD
PA
WF
-
-
G
G
V
M
AII
NN
I
TM
LAI
VLT
G
SAL
I
RERE
H
GTV
EH
LLV
M
P
I
T
PF
EI
M
M
A
K
I
WSM
G
L
V
V
L
V
V
SG
L
SLV
LM
VK---G
V
L
GVP
IE
GS
IP
LF
M
L
GVA
L
S
LFAT
T
S
I
G
IFMG
T
IAR
S
M
P
Q
L
GL
L
V
I
L
V
-
LLP
L
QM
LSG
GST
P
R
ESMP
---
Q
M
VQD
IMLTM
PT
T
HF
VS
L
AQ
A
I
LY
R
G
A
G
F
E
IVW
PQ
F
L
T
L
M
A
IGGAFFTIA
L
LRFRKTI
fig|340184.6.peg.392
Escherichia coli B7A (13-370/374)
KEL
R
SLL
G
D
-
--------KA
M
L
T
LIVF
S
F
TV
SV
YSSATVTPG
S
L
N
L
A
P
IAI
A
D
M
DQ
SQL
S
NRI
V
NS
F
Y
R
PWF
L
--P
P
E
M
I
T
A
DEMD
AG
LDAG
RY
T
F
AI
N
IPPNF
Q
R
--
D
VLA
G
R
Q
P
D
I
Q
V
N
VD
A
TRM
S
Q
A
F
T
GN
GYIQ
N
I
INGEV
N
SFVA
R
YR-
-
D
NSE
P
LV
SL
ETR
M
R
F
NPNLD
PA
WF
-
-
G
G
V
M
AII
NN
I
TM
LAI
VLT
G
SAL
I
RERE
H
GTV
EH
LLV
M
P
I
T
PF
EI
M
M
A
K
I
WSM
G
L
V
V
L
V
V
SG
L
SLV
LM
VK---G
V
L
GVP
IE
GS
IP
LF
M
L
GVA
L
S
LFAT
T
S
I
G
IFMG
T
IAR
S
M
P
Q
L
GL
L
V
I
L
V
-
LLP
L
QM
LSG
GST
P
R
ESMP
---
Q
M
VQD
IMLTM
PT
T
HF
VS
L
AQ
A
I
LY
R
G
A
G
F
E
IVW
PQ
F
L
T
L
M
A
IGGAFFTIA
L
LRFRKTI
fig|511693.5.peg.3508
Escherichia coli BL21 (13-370/374)
KEL
R
SLL
G
D
-
--------KA
M
L
T
LIVF
S
F
TV
SV
YSSATVTPG
S
L
N
L
A
P
IAI
A
D
M
DQ
SQL
S
NRI
V
NS
F
Y
R
PWF
L
--P
P
E
M
I
T
A
DEMD
AG
LDAG
RY
T
F
AI
N
IPPNF
Q
R
--
D
VLA
G
R
Q
P
D
I
Q
V
N
VD
A
TRM
S
Q
A
F
T
GN
GYIQ
N
I
INGEV
N
SFVA
R
YR-
-
D
NSE
P
LV
SL
ETR
M
R
F
NPNLD
PA
WF
-
-
G
G
V
M
AII
NN
I
TM
LAI
VLT
G
SAL
I
RERE
H
GTV
EH
LLV
M
P
I
T
PF
EI
M
M
A
K
I
WSM
G
L
V
V
L
V
V
SG
L
SLV
LM
VK---G
V
L
GVP
IE
GS
IP
LF
M
L
GVA
L
S
LFAT
T
S
I
G
IFMG
T
IAR
S
M
P
Q
L
GL
L
V
I
L
V
-
LLP
L
QM
LSG
GST
P
R
ESMP
---
Q
M
VQD
IMLTM
PT
T
HF
VS
L
AQ
A
I
LY
R
G
A
G
F
E
IVW
PQ
F
L
T
L
M
A
IGGAFFTIA
L
LRFRKTI
fig|469008.4.peg.272
Escherichia coli BL21(DE3) (13-370/374)
KEL
R
SLL
G
D
-
--------KA
M
L
T
LIVF
S
F
TV
SV
YSSATVTPG
S
L
N
L
A
P
IAI
A
D
M
DQ
SQL
S
NRI
V
NS
F
Y
R
PWF
L
--P
P
E
M
I
T
A
DEMD
AG
LDAG
RY
T
F
AI
N
IPPNF
Q
R
--
D
VLA
G
R
Q
P
D
I
Q
V
N
VD
A
TRM
S
Q
A
F
T
GN
GYIQ
N
I
INGEV
N
SFVA
R
YR-
-
D
NSE
P
LV
SL
ETR
M
R
F
NPNLD
PA
WF
-
-
G
G
V
M
AII
NN
I
TM
LAI
VLT
G
SAL
I
RERE
H
GTV
EH
LLV
M
P
I
T
PF
EI
M
M
A
K
I
WSM
G
L
V
V
L
V
V
SG
L
SLV
LM
VK---G
V
L
GVP
IE
GS
IP
LF
M
L
GVA
L
S
LFAT
T
S
I
G
IFMG
T
IAR
S
M
P
Q
L
GL
L
V
I
L
V
-
LLP
L
QM
LSG
GST
P
R
ESMP
---
Q
M
VQD
IMLTM
PT
T
HF
VS
L
AQ
A
I
LY
R
G
A
G
F
E
IVW
PQ
F
L
T
L
M
A
IGGAFFTIA
L
LRFRKTI
fig|595496.3.peg.3467
Escherichia coli BW2952 (13-370/374)
KEL
R
SLL
G
D
-
--------KA
M
L
T
LIVF
S
F
TV
SV
YSSATVTPG
S
L
N
L
A
P
IAI
A
D
M
DQ
SQL
S
NRI
V
NS
F
Y
R
PWF
L
--P
P
E
M
I
T
A
DEMD
AG
LDAG
RY
T
F
AI
N
IPPNF
Q
R
--
D
VLA
G
R
Q
P
D
I
Q
V
N
VD
A
TRM
S
Q
A
F
T
GN
GYIQ
N
I
INGEV
N
SFVA
R
YR-
-
D
NSE
P
LV
SL
ETR
M
R
F
NPNLD
PA
WF
-
-
G
G
V
M
AII
NN
I
TM
LAI
VLT
G
SAL
I
RERE
H
GTV
EH
LLV
M
P
I
T
PF
EI
M
M
A
K
I
WSM
G
L
V
V
L
V
V
SG
L
SLV
LM
VK---G
V
L
GVP
IE
GS
IP
LF
M
L
GVA
L
S
LFAT
T
S
I
G
IFMG
T
IAR
S
M
P
Q
L
GL
L
V
I
L
V
-
LLP
L
QM
LSG
GST
P
R
ESMP
---
Q
M
VQD
IMLTM
PT
T
HF
VS
L
AQ
A
I
LY
R
G
A
G
F
E
IVW
PQ
F
L
T
L
M
A
IGGAFFTIA
L
LRFRKTI
fig|536056.3.peg.242
Escherichia coli DH1 (13-370/374)
KEL
R
SLL
G
D
-
--------KA
M
L
T
LIVF
S
F
TV
SV
YSSATVTPG
S
L
N
L
A
P
IAI
A
D
M
DQ
SQL
S
NRI
V
NS
F
Y
R
PWF
L
--P
P
E
M
I
T
A
DEMD
AG
LDAG
RY
T
F
AI
N
IPPNF
Q
R
--
D
VLA
G
R
Q
P
D
I
Q
V
N
VD
A
TRM
S
Q
A
F
T
GN
GYIQ
N
I
INGEV
N
SFVA
R
YR-
-
D
NSE
P
LV
SL
ETR
M
R
F
NPNLD
PA
WF
-
-
G
G
V
M
AII
NN
I
TM
LAI
VLT
G
SAL
I
RERE
H
GTV
EH
LLV
M
P
I
T
PF
EI
M
M
A
K
I
WSM
G
L
V
V
L
V
V
SG
L
SLV
LM
VK---G
V
L
GVP
IE
GS
IP
LF
M
L
GVA
L
S
LFAT
T
S
I
G
IFMG
T
IAR
S
M
P
Q
L
GL
L
V
I
L
V
-
LLP
L
QM
LSG
GST
P
R
ESMP
---
Q
M
VQD
IMLTM
PT
T
HF
VS
L
AQ
A
I
LY
R
G
A
G
F
E
IVW
PQ
F
L
T
L
M
A
IGGAFFTIA
L
LRFRKTI
fig|340186.3.peg.2063
Escherichia coli E110019 (13-370/374)
KEL
R
SLL
G
D
-
--------KA
M
L
T
LIVF
S
F
TV
SV
YSSATVTPG
S
L
N
L
A
P
IAI
A
D
M
DQ
SQL
S
NRI
V
NS
F
Y
R
PWF
L
--P
P
E
M
I
T
A
DEMD
AG
LDAG
RY
T
F
AI
N
IPPNF
Q
R
--
D
VLA
G
R
Q
P
D
I
Q
V
N
VD
A
TRM
S
Q
A
F
T
GN
GYIQ
N
I
INGEV
N
SFVA
R
YR-
-
D
NSE
P
LV
SL
ETR
M
R
F
NPNLD
PA
WF
-
-
G
G
V
M
AII
NN
I
TM
LAI
VLT
G
SAL
I
RERE
H
GTV
EH
LLV
M
P
I
T
PF
EI
M
M
A
K
I
WSM
G
L
V
V
L
V
V
SG
L
SLV
LM
VK---G
V
L
GVP
IE
GS
IP
LF
M
L
GVA
L
S
LFAT
T
S
I
G
IFMG
T
IAR
S
M
P
Q
L
GL
L
V
I
L
V
-
LLP
L
QM
LSG
GST
P
R
ESMP
---
Q
M
VQD
IMLTM
PT
T
HF
VS
L
AQ
A
I
LY
R
G
A
G
F
E
IVW
PQ
F
L
T
L
M
A
IGGAFFTIA
L
LRFRKTI
fig|340186.3.peg.4734
Escherichia coli E110019 (13-370/374)
KEL
R
SLL
G
D
-
--------KA
M
L
T
LIVF
S
F
TV
SV
YSSATVTPG
S
L
N
L
A
P
IAI
A
D
M
DQ
SQL
S
NRI
V
NS
F
Y
R
PWF
L
--P
P
E
M
I
T
A
DEMD
AG
LDAG
RY
T
F
AI
N
IPPNF
Q
R
--
D
VLA
G
R
Q
P
D
I
Q
V
N
VD
A
TRM
S
Q
A
F
T
GN
GYIQ
N
I
INGEV
N
SFVA
R
YR-
-
D
NSE
P
LV
SL
ETR
M
R
F
NPNLD
PA
WF
-
-
G
G
V
M
AII
NN
I
TM
LAI
VLT
G
SAL
I
RERE
H
GTV
EH
LLV
M
P
I
T
PF
EI
M
M
A
K
I
WSM
G
L
V
V
L
V
V
SG
L
SLV
LM
VK---G
V
L
GVP
IE
GS
IP
LF
M
L
GVA
L
S
LFAT
T
S
I
G
IFMG
T
IAR
S
M
P
Q
L
GL
L
V
I
L
V
-
LLP
L
QM
LSG
GST
P
R
ESMP
---
Q
M
VQD
IMLTM
PT
T
HF
VS
L
AQ
A
I
LY
R
G
A
G
F
E
IVW
PQ
F
L
T
L
M
A
IGGAFFTIA
L
LRFRKTI
fig|340186.5.peg.2126
Escherichia coli E110019 (13-370/374)
KEL
R
SLL
G
D
-
--------KA
M
L
T
LIVF
S
F
TV
SV
YSSATVTPG
S
L
N
L
A
P
IAI
A
D
M
DQ
SQL
S
NRI
V
NS
F
Y
R
PWF
L
--P
P
E
M
I
T
A
DEMD
AG
LDAG
RY
T
F
AI
N
IPPNF
Q
R
--
D
VLA
G
R
Q
P
D
I
Q
V
N
VD
A
TRM
S
Q
A
F
T
GN
GYIQ
N
I
INGEV
N
SFVA
R
YR-
-
D
NSE
P
LV
SL
ETR
M
R
F
NPNLD
PA
WF
-
-
G
G
V
M
AII
NN
I
TM
LAI
VLT
G
SAL
I
RERE
H
GTV
EH
LLV
M
P
I
T
PF
EI
M
M
A
K
I
WSM
G
L
V
V
L
V
V
SG
L
SLV
LM
VK---G
V
L
GVP
IE
GS
IP
LF
M
L
GVA
L
S
LFAT
T
S
I
G
IFMG
T
IAR
S
M
P
Q
L
GL
L
V
I
L
V
-
LLP
L
QM
LSG
GST
P
R
ESMP
---
Q
M
VQD
IMLTM
PT
T
HF
VS
L
AQ
A
I
LY
R
G
A
G
F
E
IVW
PQ
F
L
T
L
M
A
IGGAFFTIA
L
LRFRKTI
fig|340186.5.peg.4994
Escherichia coli E110019 (13-370/374)
KEL
R
SLL
G
D
-
--------KA
M
L
T
LIVF
S
F
TV
SV
YSSATVTPG
S
L
N
L
A
P
IAI
A
D
M
DQ
SQL
S
NRI
V
NS
F
Y
R
PWF
L
--P
P
E
M
I
T
A
DEMD
AG
LDAG
RY
T
F
AI
N
IPPNF
Q
R
--
D
VLA
G
R
Q
P
D
I
Q
V
N
VD
A
TRM
S
Q
A
F
T
GN
GYIQ
N
I
INGEV
N
SFVA
R
YR-
-
D
NSE
P
LV
SL
ETR
M
R
F
NPNLD
PA
WF
-
-
G
G
V
M
AII
NN
I
TM
LAI
VLT
G
SAL
I
RERE
H
GTV
EH
LLV
M
P
I
T
PF
EI
M
M
A
K
I
WSM
G
L
V
V
L
V
V
SG
L
SLV
LM
VK---G
V
L
GVP
IE
GS
IP
LF
M
L
GVA
L
S
LFAT
T
S
I
G
IFMG
T
IAR
S
M
P
Q
L
GL
L
V
I
L
V
-
LLP
L
QM
LSG
GST
P
R
ESMP
---
Q
M
VQD
IMLTM
PT
T
HF
VS
L
AQ
A
I
LY
R
G
A
G
F
E
IVW
PQ
F
L
T
L
M
A
IGGAFFTIA
L
LRFRKTI
fig|340185.3.peg.118
Escherichia coli E22 (13-370/374)
KEL
R
SLL
G
D
-
--------KA
M
L
T
LIVF
S
F
TV
SV
YSSATVTPG
S
L
N
L
A
P
IAI
A
D
M
DQ
SQL
S
NRI
V
NS
F
Y
R
PWF
L
--P
P
E
M
I
T
A
DEMD
AG
LDAG
RY
T
F
AI
N
IPPNF
Q
R
--
D
VLA
G
R
Q
P
D
I
Q
V
N
VD
A
TRM
S
Q
A
F
T
GN
GYIQ
N
I
INGEV
N
SFVA
R
YR-
-
D
NSE
P
LV
SL
ETR
M
R
F
NPNLD
PA
WF
-
-
G
G
V
M
AII
NN
I
TM
LAI
VLT
G
SAL
I
RERE
H
GTV
EH
LLV
M
P
I
T
PF
EI
M
M
A
K
I
WSM
G
L
V
V
L
V
V
SG
L
SLV
LM
VK---G
V
L
GVP
IE
GS
IP
LF
M
L
GVA
L
S
LFAT
T
S
I
G
IFMG
T
IAR
S
M
P
Q
L
GL
L
V
I
L
V
-
LLP
L
QM
LSG
GST
P
R
ESMP
---
Q
M
VQD
IMLTM
PT
T
HF
VS
L
AQ
A
I
LY
R
G
A
G
F
E
IVW
PQ
F
L
T
L
M
A
IGGAFFTIA
L
LRFRKTI
fig|340185.4.peg.132
Escherichia coli E22 (13-370/374)
KEL
R
SLL
G
D
-
--------KA
M
L
T
LIVF
S
F
TV
SV
YSSATVTPG
S
L
N
L
A
P
IAI
A
D
M
DQ
SQL
S
NRI
V
NS
F
Y
R
PWF
L
--P
P
E
M
I
T
A
DEMD
AG
LDAG
RY
T
F
AI
N
IPPNF
Q
R
--
D
VLA
G
R
Q
P
D
I
Q
V
N
VD
A
TRM
S
Q
A
F
T
GN
GYIQ
N
I
INGEV
N
SFVA
R
YR-
-
D
NSE
P
LV
SL
ETR
M
R
F
NPNLD
PA
WF
-
-
G
G
V
M
AII
NN
I
TM
LAI
VLT
G
SAL
I
RERE
H
GTV
EH
LLV
M
P
I
T
PF
EI
M
M
A
K
I
WSM
G
L
V
V
L
V
V
SG
L
SLV
LM
VK---G
V
L
GVP
IE
GS
IP
LF
M
L
GVA
L
S
LFAT
T
S
I
G
IFMG
T
IAR
S
M
P
Q
L
GL
L
V
I
L
V
-
LLP
L
QM
LSG
GST
P
R
ESMP
---
Q
M
VQD
IMLTM
PT
T
HF
VS
L
AQ
A
I
LY
R
G
A
G
F
E
IVW
PQ
F
L
T
L
M
A
IGGAFFTIA
L
LRFRKTI
fig|316401.4.peg.4227
Escherichia coli ETEC H10407 (13-370/374)
KEL
R
SLL
G
D
-
--------KA
M
L
T
LIVF
S
F
TV
SV
YSSATVTPG
S
L
N
L
A
P
IAI
A
D
M
DQ
SQL
S
NRI
V
NS
F
Y
R
PWF
L
--P
P
E
M
I
T
A
DEMD
AG
LDAG
RY
T
F
AI
N
IPPNF
Q
R
--
D
VLA
G
R
Q
P
D
I
Q
V
N
VD
A
TRM
S
Q
A
F
T
GN
GYIQ
N
I
INGEV
N
SFVA
R
YR-
-
D
NSE
P
LV
SL
ETR
M
R
F
NPNLD
PA
WF
-
-
G
G
V
M
AII
NN
I
TM
LAI
VLT
G
SAL
I
RERE
H
GTV
EH
LLV
M
P
I
T
PF
EI
M
M
A
K
I
WSM
G
L
V
V
L
V
V
SG
L
SLV
LM
VK---G
V
L
GVP
IE
GS
IP
LF
M
L
GVA
L
S
LFAT
T
S
I
G
IFMG
T
IAR
S
M
P
Q
L
GL
L
V
I
L
V
-
LLP
L
QM
LSG
GST
P
R
ESMP
---
Q
M
VQD
IMLTM
PT
T
HF
VS
L
AQ
A
I
LY
R
G
A
G
F
E
IVW
PQ
F
L
T
L
M
A
IGGAFFTIA
L
LRFRKTI
fig|656414.3.peg.3974
Escherichia coli H736 (13-370/374)
KEL
R
SLL
G
D
-
--------KA
M
L
T
LIVF
S
F
TV
SV
YSSATVTPG
S
L
N
L
A
P
IAI
A
D
M
DQ
SQL
S
NRI
V
NS
F
Y
R
PWF
L
--P
P
E
M
I
T
A
DEMD
AG
LDAG
RY
T
F
AI
N
IPPNF
Q
R
--
D
VLA
G
R
Q
P
D
I
Q
V
N
VD
A
TRM
S
Q
A
F
T
GN
GYIQ
N
I
INGEV
N
SFVA
R
YR-
-
D
NSE
P
LV
SL
ETR
M
R
F
NPNLD
PA
WF
-
-
G
G
V
M
AII
NN
I
TM
LAI
VLT
G
SAL
I
RERE
H
GTV
EH
LLV
M
P
I
T
PF
EI
M
M
A
K
I
WSM
G
L
V
V
L
V
V
SG
L
SLV
LM
VK---G
V
L
GVP
IE
GS
IP
LF
M
L
GVA
L
S
LFAT
T
S
I
G
IFMG
T
IAR
S
M
P
Q
L
GL
L
V
I
L
V
-
LLP
L
QM
LSG
GST
P
R
ESMP
---
Q
M
VQD
IMLTM
PT
T
HF
VS
L
AQ
A
I
LY
R
G
A
G
F
E
IVW
PQ
F
L
T
L
M
A
IGGAFFTIA
L
LRFRKTI
fig|83333.1.peg.3418
Escherichia coli K12 (13-370/374)
KEL
R
SLL
G
D
-
--------KA
M
L
T
LIVF
S
F
TV
SV
YSSATVTPG
S
L
N
L
A
P
IAI
A
D
M
DQ
SQL
S
NRI
V
NS
F
Y
R
PWF
L
--P
P
E
M
I
T
A
DEMD
AG
LDAG
RY
T
F
AI
N
IPPNF
Q
R
--
D
VLA
G
R
Q
P
D
I
Q
V
N
VD
A
TRM
S
Q
A
F
T
GN
GYIQ
N
I
INGEV
N
SFVA
R
YR-
-
D
NSE
P
LV
SL
ETR
M
R
F
NPNLD
PA
WF
-
-
G
G
V
M
AII
NN
I
TM
LAI
VLT
G
SAL
I
RERE
H
GTV
EH
LLV
M
P
I
T
PF
EI
M
M
A
K
I
WSM
G
L
V
V
L
V
V
SG
L
SLV
LM
VK---G
V
L
GVP
IE
GS
IP
LF
M
L
GVA
L
S
LFAT
T
S
I
G
IFMG
T
IAR
S
M
P
Q
L
GL
L
V
I
L
V
-
LLP
L
QM
LSG
GST
P
R
ESMP
---
Q
M
VQD
IMLTM
PT
T
HF
VS
L
AQ
A
I
LY
R
G
A
G
F
E
IVW
PQ
F
L
T
L
M
A
IGGAFFTIA
L
LRFRKTI
fig|749538.3.peg.4010
Escherichia coli MS 116-1 (13-370/374)
KEL
R
SLL
G
D
-
--------KA
M
L
T
LIVF
S
F
TV
SV
YSSATVTPG
S
L
N
L
A
P
IAI
A
D
M
DQ
SQL
S
NRI
V
NS
F
Y
R
PWF
L
--P
P
E
M
I
T
A
DEMD
AG
LDAG
RY
T
F
AI
N
IPPNF
Q
R
--
D
VLA
G
R
Q
P
D
I
Q
V
N
VD
A
TRM
S
Q
A
F
T
GN
GYIQ
N
I
INGEV
N
SFVA
R
YR-
-
D
NSE
P
LV
SL
ETR
M
R
F
NPNLD
PA
WF
-
-
G
G
V
M
AII
NN
I
TM
LAI
VLT
G
SAL
I
RERE
H
GTV
EH
LLV
M
P
I
T
PF
EI
M
M
A
K
I
WSM
G
L
V
V
L
V
V
SG
L
SLV
LM
VK---G
V
L
GVP
IE
GS
IP
LF
M
L
GVA
L
S
LFAT
T
S
I
G
IFMG
T
IAR
S
M
P
Q
L
GL
L
V
I
L
V
-
LLP
L
QM
LSG
GST
P
R
ESMP
---
Q
M
VQD
IMLTM
PT
T
HF
VS
L
AQ
A
I
LY
R
G
A
G
F
E
IVW
PQ
F
L
T
L
M
A
IGGAFFTIA
L
LRFRKTI
fig|679204.3.peg.4569
Escherichia coli MS 145-7 (13-370/374)
KEL
R
SLL
G
D
-
--------KA
M
L
T
LIVF
S
F
TV
SV
YSSATVTPG
S
L
N
L
A
P
IAI
A
D
M
DQ
SQL
S
NRI
V
NS
F
Y
R
PWF
L
--P
P
E
M
I
T
A
DEMD
AG
LDAG
RY
T
F
AI
N
IPPNF
Q
R
--
D
VLA
G
R
Q
P
D
I
Q
V
N
VD
A
TRM
S
Q
A
F
T
GN
GYIQ
N
I
INGEV
N
SFVA
R
YR-
-
D
NSE
P
LV
SL
ETR
M
R
F
NPNLD
PA
WF
-
-
G
G
V
M
AII
NN
I
TM
LAI
VLT
G
SAL
I
RERE
H
GTV
EH
LLV
M
P
I
T
PF
EI
M
M
A
K
I
WSM
G
L
V
V
L
V
V
SG
L
SLV
LM
VK---G
V
L
GVP
IE
GS
IP
LF
M
L
GVA
L
S
LFAT
T
S
I
G
IFMG
T
IAR
S
M
P
Q
L
GL
L
V
I
L
V
-
LLP
L
QM
LSG
GST
P
R
ESMP
---
Q
M
VQD
IMLTM
PT
T
HF
VS
L
AQ
A
I
LY
R
G
A
G
F
E
IVW
PQ
F
L
T
L
M
A
IGGAFFTIA
L
LRFRKTI
fig|749540.3.peg.1966
Escherichia coli MS 146-1 (13-370/374)
KEL
R
SLL
G
D
-
--------KA
M
L
T
LIVF
S
F
TV
SV
YSSATVTPG
S
L
N
L
A
P
IAI
A
D
M
DQ
SQL
S
NRI
V
NS
F
Y
R
PWF
L
--P
P
E
M
I
T
A
DEMD
AG
LDAG
RY
T
F
AI
N
IPPNF
Q
R
--
D
VLA
G
R
Q
P
D
I
Q
V
N
VD
A
TRM
S
Q
A
F
T
GN
GYIQ
N
I
INGEV
N
SFVA
R
YR-
-
D
NSE
P
LV
SL
ETR
M
R
F
NPNLD
PA
WF
-
-
G
G
V
M
AII
NN
I
TM
LAI
VLT
G
SAL
I
RERE
H
GTV
EH
LLV
M
P
I
T
PF
EI
M
M
A
K
I
WSM
G
L
V
V
L
V
V
SG
L
SLV
LM
VK---G
V
L
GVP
IE
GS
IP
LF
M
L
GVA
L
S
LFAT
T
S
I
G
IFMG
T
IAR
S
M
P
Q
L
GL
L
V
I
L
V
-
LLP
L
QM
LSG
GST
P
R
ESMP
---
Q
M
VQD
IMLTM
PT
T
HF
VS
L
AQ
A
I
LY
R
G
A
G
F
E
IVW
PQ
F
L
T
L
M
A
IGGAFFTIA
L
LRFRKTI
fig|749544.3.peg.3013
Escherichia coli MS 175-1 (13-370/374)
KEL
R
SLL
G
D
-
--------KA
M
L
T
LIVF
S
F
TV
SV
YSSATVTPG
S
L
N
L
A
P
IAI
A
D
M
DQ
SQL
S
NRI
V
NS
F
Y
R
PWF
L
--P
P
E
M
I
T
A
DEMD
AG
LDAG
RY
T
F
AI
N
IPPNF
Q
R
--
D
VLA
G
R
Q
P
D
I
Q
V
N
VD
A
TRM
S
Q
A
F
T
GN
GYIQ
N
I
INGEV
N
SFVA
R
YR-
-
D
NSE
P
LV
SL
ETR
M
R
F
NPNLD
PA
WF
-
-
G
G
V
M
AII
NN
I
TM
LAI
VLT
G
SAL
I
RERE
H
GTV
EH
LLV
M
P
I
T
PF
EI
M
M
A
K
I
WSM
G
L
V
V
L
V
V
SG
L
SLV
LM
VK---G
V
L
GVP
IE
GS
IP
LF
M
L
GVA
L
S
LFAT
T
S
I
G
IFMG
T
IAR
S
M
P
Q
L
GL
L
V
I
L
V
-
LLP
L
QM
LSG
GST
P
R
ESMP
---
Q
M
VQD
IMLTM
PT
T
HF
VS
L
AQ
A
I
LY
R
G
A
G
F
E
IVW
PQ
F
L
T
L
M
A
IGGAFFTIA
L
LRFRKTI
fig|749547.3.peg.1956
Escherichia coli MS 187-1 (13-370/374)
KEL
R
SLL
G
D
-
--------KA
M
L
T
LIVF
S
F
TV
SV
YSSATVTPG
S
L
N
L
A
P
IAI
A
D
M
DQ
SQL
S
NRI
V
NS
F
Y
R
PWF
L
--P
P
E
M
I
T
A
DEMD
AG
LDAG
RY
T
F
AI
N
IPPNF
Q
R
--
D
VLA
G
R
Q
P
D
I
Q
V
N
VD
A
TRM
S
Q
A
F
T
GN
GYIQ
N
I
INGEV
N
SFVA
R
YR-
-
D
NSE
P
LV
SL
ETR
M
R
F
NPNLD
PA
WF
-
-
G
G
V
M
AII
NN
I
TM
LAI
VLT
G
SAL
I
RERE
H
GTV
EH
LLV
M
P
I
T
PF
EI
M
M
A
K
I
WSM
G
L
V
V
L
V
V
SG
L
SLV
LM
VK---G
V
L
GVP
IE
GS
IP
LF
M
L
GVA
L
S
LFAT
T
S
I
G
IFMG
T
IAR
S
M
P
Q
L
GL
L
V
I
L
V
-
LLP
L
QM
LSG
GST
P
R
ESMP
---
Q
M
VQD
IMLTM
PT
T
HF
VS
L
AQ
A
I
LY
R
G
A
G
F
E
IVW
PQ
F
L
T
L
M
A
IGGAFFTIA
L
LRFRKTI
fig|749548.3.peg.121
Escherichia coli MS 196-1 (13-370/374)
KEL
R
SLL
G
D
-
--------KA
M
L
T
LIVF
S
F
TV
SV
YSSATVTPG
S
L
N
L
A
P
IAI
A
D
M
DQ
SQL
S
NRI
V
NS
F
Y
R
PWF
L
--P
P
E
M
I
T
A
DEMD
AG
LDAG
RY
T
F
AI
N
IPPNF
Q
R
--
D
VLA
G
R
Q
P
D
I
Q
V
N
VD
A
TRM
S
Q
A
F
T
GN
GYIQ
N
I
INGEV
N
SFVA
R
YR-
-
D
NSE
P
LV
SL
ETR
M
R
F
NPNLD
PA
WF
-
-
G
G
V
M
AII
NN
I
TM
LAI
VLT
G
SAL
I
RERE
H
GTV
EH
LLV
M
P
I
T
PF
EI
M
M
A
K
I
WSM
G
L
V
V
L
V
V
SG
L
SLV
LM
VK---G
V
L
GVP
IE
GS
IP
LF
M
L
GVA
L
S
LFAT
T
S
I
G
IFMG
T
IAR
S
M
P
Q
L
GL
L
V
I
L
V
-
LLP
L
QM
LSG
GST
P
R
ESMP
---
Q
M
VQD
IMLTM
PT
T
HF
VS
L
AQ
A
I
LY
R
G
A
G
F
E
IVW
PQ
F
L
T
L
M
A
IGGAFFTIA
L
LRFRKTI
fig|749531.3.peg.1587
Escherichia coli MS 69-1 (13-370/374)
KEL
R
SLL
G
D
-
--------KA
M
L
T
LIVF
S
F
TV
SV
YSSATVTPG
S
L
N
L
A
P
IAI
A
D
M
DQ
SQL
S
NRI
V
NS
F
Y
R
PWF
L
--P
P
E
M
I
T
A
DEMD
AG
LDAG
RY
T
F
AI
N
IPPNF
Q
R
--
D
VLA
G
R
Q
P
D
I
Q
V
N
VD
A
TRM
S
Q
A
F
T
GN
GYIQ
N
I
INGEV
N
SFVA
R
YR-
-
D
NSE
P
LV
SL
ETR
M
R
F
NPNLD
PA
WF
-
-
G
G
V
M
AII
NN
I
TM
LAI
VLT
G
SAL
I
RERE
H
GTV
EH
LLV
M
P
I
T
PF
EI
M
M
A
K
I
WSM
G
L
V
V
L
V
V
SG
L
SLV
LM
VK---G
V
L
GVP
IE
GS
IP
LF
M
L
GVA
L
S
LFAT
T
S
I
G
IFMG
T
IAR
S
M
P
Q
L
GL
L
V
I
L
V
-
LLP
L
QM
LSG
GST
P
R
ESMP
---
Q
M
VQD
IMLTM
PT
T
HF
VS
L
AQ
A
I
LY
R
G
A
G
F
E
IVW
PQ
F
L
T
L
M
A
IGGAFFTIA
L
LRFRKTI
fig|585395.4.peg.4399
Escherichia coli O103:H2 str. 12009 (13-370/374)
KEL
R
SLL
G
D
-
--------KA
M
L
T
LIVF
S
F
TV
SV
YSSATVTPG
S
L
N
L
A
P
IAI
A
D
M
DQ
SQL
S
NRI
V
NS
F
Y
R
PWF
L
--P
P
E
M
I
T
A
DEMD
AG
LDAG
RY
T
F
AI
N
IPPNF
Q
R
--
D
VLA
G
R
Q
P
D
I
Q
V
N
VD
A
TRM
S
Q
A
F
T
GN
GYIQ
N
I
INGEV
N
SFVA
R
YR-
-
D
NSE
P
LV
SL
ETR
M
R
F
NPNLD
PA
WF
-
-
G
G
V
M
AII
NN
I
TM
LAI
VLT
G
SAL
I
RERE
H
GTV
EH
LLV
M
P
I
T
PF
EI
M
M
A
K
I
WSM
G
L
V
V
L
V
V
SG
L
SLV
LM
VK---G
V
L
GVP
IE
GS
IP
LF
M
L
GVA
L
S
LFAT
T
S
I
G
IFMG
T
IAR
S
M
P
Q
L
GL
L
V
I
L
V
-
LLP
L
QM
LSG
GST
P
R
ESMP
---
Q
M
VQD
IMLTM
PT
T
HF
VS
L
AQ
A
I
LY
R
G
A
G
F
E
IVW
PQ
F
L
T
L
M
A
IGGAFFTIA
L
LRFRKTI
fig|637912.3.peg.4056
Escherichia coli OP50 (13-370/374)
KEL
R
SLL
G
D
-
--------KA
M
L
T
LIVF
S
F
TV
SV
YSSATVTPG
S
L
N
L
A
P
IAI
A
D
M
DQ
SQL
S
NRI
V
NS
F
Y
R
PWF
L
--P
P
E
M
I
T
A
DEMD
AG
LDAG
RY
T
F
AI
N
IPPNF
Q
R
--
D
VLA
G
R
Q
P
D
I
Q
V
N
VD
A
TRM
S
Q
A
F
T
GN
GYIQ
N
I
INGEV
N
SFVA
R
YR-
-
D
NSE
P
LV
SL
ETR
M
R
F
NPNLD
PA
WF
-
-
G
G
V
M
AII
NN
I
TM
LAI
VLT
G
SAL
I
RERE
H
GTV
EH
LLV
M
P
I
T
PF
EI
M
M
A
K
I
WSM
G
L
V
V
L
V
V
SG
L
SLV
LM
VK---G
V
L
GVP
IE
GS
IP
LF
M
L
GVA
L
S
LFAT
T
S
I
G
IFMG
T
IAR
S
M
P
Q
L
GL
L
V
I
L
V
-
LLP
L
QM
LSG
GST
P
R
ESMP
---
Q
M
VQD
IMLTM
PT
T
HF
VS
L
AQ
A
I
LY
R
G
A
G
F
E
IVW
PQ
F
L
T
L
M
A
IGGAFFTIA
L
LRFRKTI
fig|316407.3.peg.3643
Escherichia coli W3110 (13-370/374)
KEL
R
SLL
G
D
-
--------KA
M
L
T
LIVF
S
F
TV
SV
YSSATVTPG
S
L
N
L
A
P
IAI
A
D
M
DQ
SQL
S
NRI
V
NS
F
Y
R
PWF
L
--P
P
E
M
I
T
A
DEMD
AG
LDAG
RY
T
F
AI
N
IPPNF
Q
R
--
D
VLA
G
R
Q
P
D
I
Q
V
N
VD
A
TRM
S
Q
A
F
T
GN
GYIQ
N
I
INGEV
N
SFVA
R
YR-
-
D
NSE
P
LV
SL
ETR
M
R
F
NPNLD
PA
WF
-
-
G
G
V
M
AII
NN
I
TM
LAI
VLT
G
SAL
I
RERE
H
GTV
EH
LLV
M
P
I
T
PF
EI
M
M
A
K
I
WSM
G
L
V
V
L
V
V
SG
L
SLV
LM
VK---G
V
L
GVP
IE
GS
IP
LF
M
L
GVA
L
S
LFAT
T
S
I
G
IFMG
T
IAR
S
M
P
Q
L
GL
L
V
I
L
V
-
LLP
L
QM
LSG
GST
P
R
ESMP
---
Q
M
VQD
IMLTM
PT
T
HF
VS
L
AQ
A
I
LY
R
G
A
G
F
E
IVW
PQ
F
L
T
L
M
A
IGGAFFTIA
L
LRFRKTI
fig|316385.7.peg.3687
Escherichia coli str. K-12 substr. DH10B (13-370/374)
KEL
R
SLL
G
D
-
--------KA
M
L
T
LIVF
S
F
TV
SV
YSSATVTPG
S
L
N
L
A
P
IAI
A
D
M
DQ
SQL
S
NRI
V
NS
F
Y
R
PWF
L
--P
P
E
M
I
T
A
DEMD
AG
LDAG
RY
T
F
AI
N
IPPNF
Q
R
--
D
VLA
G
R
Q
P
D
I
Q
V
N
VD
A
TRM
S
Q
A
F
T
GN
GYIQ
N
I
INGEV
N
SFVA
R
YR-
-
D
NSE
P
LV
SL
ETR
M
R
F
NPNLD
PA
WF
-
-
G
G
V
M
AII
NN
I
TM
LAI
VLT
G
SAL
I
RERE
H
GTV
EH
LLV
M
P
I
T
PF
EI
M
M
A
K
I
WSM
G
L
V
V
L
V
V
SG
L
SLV
LM
VK---G
V
L
GVP
IE
GS
IP
LF
M
L
GVA
L
S
LFAT
T
S
I
G
IFMG
T
IAR
S
M
P
Q
L
GL
L
V
I
L
V
-
LLP
L
QM
LSG
GST
P
R
ESMP
---
Q
M
VQD
IMLTM
PT
T
HF
VS
L
AQ
A
I
LY
R
G
A
G
F
E
IVW
PQ
F
L
T
L
M
A
IGGAFFTIA
L
LRFRKTI
fig|511145.12.peg.3584
Escherichia coli str. K-12 substr. MG1655 (13-370/374)
KEL
R
SLL
G
D
-
--------KA
M
L
T
LIVF
S
F
TV
SV
YSSATVTPG
S
L
N
L
A
P
IAI
A
D
M
DQ
SQL
S
NRI
V
NS
F
Y
R
PWF
L
--P
P
E
M
I
T
A
DEMD
AG
LDAG
RY
T
F
AI
N
IPPNF
Q
R
--
D
VLA
G
R
Q
P
D
I
Q
V
N
VD
A
TRM
S
Q
A
F
T
GN
GYIQ
N
I
INGEV
N
SFVA
R
YR-
-
D
NSE
P
LV
SL
ETR
M
R
F
NPNLD
PA
WF
-
-
G
G
V
M
AII
NN
I
TM
LAI
VLT
G
SAL
I
RERE
H
GTV
EH
LLV
M
P
I
T
PF
EI
M
M
A
K
I
WSM
G
L
V
V
L
V
V
SG
L
SLV
LM
VK---G
V
L
GVP
IE
GS
IP
LF
M
L
GVA
L
S
LFAT
T
S
I
G
IFMG
T
IAR
S
M
P
Q
L
GL
L
V
I
L
V
-
LLP
L
QM
LSG
GST
P
R
ESMP
---
Q
M
VQD
IMLTM
PT
T
HF
VS
L
AQ
A
I
LY
R
G
A
G
F
E
IVW
PQ
F
L
T
L
M
A
IGGAFFTIA
L
LRFRKTI
fig|511145.6.peg.3567
Escherichia coli str. K-12 substr. MG1655 (13-370/374)
KEL
R
SLL
G
D
-
--------KA
M
L
T
LIVF
S
F
TV
SV
YSSATVTPG
S
L
N
L
A
P
IAI
A
D
M
DQ
SQL
S
NRI
V
NS
F
Y
R
PWF
L
--P
P
E
M
I
T
A
DEMD
AG
LDAG
RY
T
F
AI
N
IPPNF
Q
R
--
D
VLA
G
R
Q
P
D
I
Q
V
N
VD
A
TRM
S
Q
A
F
T
GN
GYIQ
N
I
INGEV
N
SFVA
R
YR-
-
D
NSE
P
LV
SL
ETR
M
R
F
NPNLD
PA
WF
-
-
G
G
V
M
AII
NN
I
TM
LAI
VLT
G
SAL
I
RERE
H
GTV
EH
LLV
M
P
I
T
PF
EI
M
M
A
K
I
WSM
G
L
V
V
L
V
V
SG
L
SLV
LM
VK---G
V
L
GVP
IE
GS
IP
LF
M
L
GVA
L
S
LFAT
T
S
I
G
IFMG
T
IAR
S
M
P
Q
L
GL
L
V
I
L
V
-
LLP
L
QM
LSG
GST
P
R
ESMP
---
Q
M
VQD
IMLTM
PT
T
HF
VS
L
AQ
A
I
LY
R
G
A
G
F
E
IVW
PQ
F
L
T
L
M
A
IGGAFFTIA
L
LRFRKTI
fig|670888.3.peg.2763
Escherichia coli 1827-70 (13-370/374)
KEL
R
SLL
G
D
-
--------KA
M
L
T
LIVF
S
F
TV
SV
YSSATVTPG
S
L
N
L
A
P
IAI
A
D
M
DQ
SQL
S
NRI
V
NS
F
Y
R
PWF
L
--P
P
E
M
I
T
A
DEMD
AG
LDAG
RY
T
F
AI
N
IPPNF
Q
R
--
D
VLA
G
R
Q
P
D
I
Q
V
N
VD
A
TRM
S
Q
A
F
T
GN
GYIQ
N
I
INGEV
N
SFVA
R
YR-
-
D
NSE
P
LV
SL
ETR
M
R
F
NPNLD
PA
WF
-
-
G
G
V
M
AII
NN
I
TM
LAI
VLT
G
SAL
I
RERE
H
GTV
EH
LLV
M
P
I
T
PF
EI
M
M
A
K
I
WSM
G
L
V
V
L
V
V
SG
L
SLV
LM
VK---G
V
L
GVP
IE
GS
IP
LF
M
L
GVA
L
S
LFAT
T
S
I
G
IFMG
T
IAR
S
M
P
Q
L
GL
L
V
I
L
V
-
LLP
L
QM
LSG
GST
P
R
ESMP
---
Q
M
VQD
TMLTM
PT
T
HF
VS
L
AQ
A
I
LY
R
G
A
G
F
E
IVW
PQ
F
L
T
L
M
A
IGGAFFTIA
L
LRFRKTI
fig|481805.3.peg.242
Escherichia coli ATCC 8739 (13-370/374)
KEL
R
SLL
G
D
-
--------KA
M
L
T
LIVF
S
F
TV
SV
YSSATVTPG
S
L
N
L
A
P
IAI
A
D
M
DQ
SQL
S
NRI
V
NS
F
Y
R
PWF
L
--P
P
E
M
I
T
A
DEMD
AG
LDAG
RY
T
F
AI
N
IPPNF
Q
R
--
D
VLA
G
R
Q
P
D
I
Q
V
N
VD
A
TRM
S
Q
A
F
T
GN
GYIQ
N
I
INGEV
N
SFVA
R
YR-
-
D
NSE
P
LV
SL
ETR
M
R
F
NPNLD
PA
WF
-
-
G
G
V
M
AII
NN
I
TM
LAI
VLT
G
SAL
I
RERE
H
GTV
EH
LLV
M
P
I
T
PF
EI
M
M
A
K
I
WSM
G
L
V
V
L
V
V
SG
L
SLV
LM
VK---G
V
L
GVP
IE
GS
IP
LF
M
L
GVA
L
S
LFAT
T
S
I
G
IFMG
T
IAR
S
M
P
Q
L
GL
L
V
I
L
V
-
LLP
L
QM
LSG
GST
P
R
ESMP
---
Q
M
VQD
TMLTM
PT
T
HF
VS
L
AQ
A
I
LY
R
G
A
G
F
E
IVW
PQ
F
L
T
L
M
A
IGGAFFTIA
L
LRFRKTI
fig|481805.6.peg.252
Escherichia coli ATCC 8739 (13-370/374)
KEL
R
SLL
G
D
-
--------KA
M
L
T
LIVF
S
F
TV
SV
YSSATVTPG
S
L
N
L
A
P
IAI
A
D
M
DQ
SQL
S
NRI
V
NS
F
Y
R
PWF
L
--P
P
E
M
I
T
A
DEMD
AG
LDAG
RY
T
F
AI
N
IPPNF
Q
R
--
D
VLA
G
R
Q
P
D
I
Q
V
N
VD
A
TRM
S
Q
A
F
T
GN
GYIQ
N
I
INGEV
N
SFVA
R
YR-
-
D
NSE
P
LV
SL
ETR
M
R
F
NPNLD
PA
WF
-
-
G
G
V
M
AII
NN
I
TM
LAI
VLT
G
SAL
I
RERE
H
GTV
EH
LLV
M
P
I
T
PF
EI
M
M
A
K
I
WSM
G
L
V
V
L
V
V
SG
L
SLV
LM
VK---G
V
L
GVP
IE
GS
IP
LF
M
L
GVA
L
S
LFAT
T
S
I
G
IFMG
T
IAR
S
M
P
Q
L
GL
L
V
I
L
V
-
LLP
L
QM
LSG
GST
P
R
ESMP
---
Q
M
VQD
TMLTM
PT
T
HF
VS
L
AQ
A
I
LY
R
G
A
G
F
E
IVW
PQ
F
L
T
L
M
A
IGGAFFTIA
L
LRFRKTI
fig|331112.3.peg.3456
Escherichia coli HS (13-370/374)
KEL
R
SLL
G
D
-
--------KA
M
L
T
LIVF
S
F
TV
SV
YSSATVTPG
S
L
N
L
A
P
IAI
A
D
M
DQ
SQL
S
NRI
V
NS
F
Y
R
PWF
L
--P
P
E
M
I
T
A
DEMD
AG
LDAG
RY
T
F
AI
N
IPPNF
Q
R
--
D
VLA
G
R
Q
P
D
I
Q
V
N
VD
A
TRM
S
Q
A
F
T
GN
GYIQ
N
I
INGEV
N
SFVA
R
YR-
-
D
NSE
P
LV
SL
ETR
M
R
F
NPNLD
PA
WF
-
-
G
G
V
M
AII
NN
I
TM
LAI
VLT
G
SAL
I
RERE
H
GTV
EH
LLV
M
P
I
T
PF
EI
M
M
A
K
I
WSM
G
L
V
V
L
V
V
SG
L
SLV
LM
VK---G
V
L
GVP
IE
GS
IP
LF
M
L
GVA
L
S
LFAT
T
S
I
G
IFMG
T
IAR
S
M
P
Q
L
GL
L
V
I
L
V
-
LLP
L
QM
LSG
GST
P
R
ESMP
---
Q
M
VQD
TMLTM
PT
T
HF
VS
L
AQ
A
I
LY
R
G
A
G
F
E
IVW
PQ
F
L
T
L
M
A
IGGAFFTIA
L
LRFRKTI
fig|331112.6.peg.3591
Escherichia coli HS (13-370/374)
KEL
R
SLL
G
D
-
--------KA
M
L
T
LIVF
S
F
TV
SV
YSSATVTPG
S
L
N
L
A
P
IAI
A
D
M
DQ
SQL
S
NRI
V
NS
F
Y
R
PWF
L
--P
P
E
M
I
T
A
DEMD
AG
LDAG
RY
T
F
AI
N
IPPNF
Q
R
--
D
VLA
G
R
Q
P
D
I
Q
V
N
VD
A
TRM
S
Q
A
F
T
GN
GYIQ
N
I
INGEV
N
SFVA
R
YR-
-
D
NSE
P
LV
SL
ETR
M
R
F
NPNLD
PA
WF
-
-
G
G
V
M
AII
NN
I
TM
LAI
VLT
G
SAL
I
RERE
H
GTV
EH
LLV
M
P
I
T
PF
EI
M
M
A
K
I
WSM
G
L
V
V
L
V
V
SG
L
SLV
LM
VK---G
V
L
GVP
IE
GS
IP
LF
M
L
GVA
L
S
LFAT
T
S
I
G
IFMG
T
IAR
S
M
P
Q
L
GL
L
V
I
L
V
-
LLP
L
QM
LSG
GST
P
R
ESMP
---
Q
M
VQD
TMLTM
PT
T
HF
VS
L
AQ
A
I
LY
R
G
A
G
F
E
IVW
PQ
F
L
T
L
M
A
IGGAFFTIA
L
LRFRKTI
fig|656379.3.peg.4786
Escherichia coli FVEC1302 (13-370/374)
KEL
R
SLL
G
D
-
--------KA
M
L
T
LIVF
S
F
TV
SV
YSSATVTPG
S
L
N
L
A
P
I
S
I
A
D
M
DQ
SQL
S
NRI
V
NS
F
Y
R
PWF
L
--P
P
E
M
I
T
A
DEMD
AG
LDAG
RY
T
F
AI
N
IPPNF
Q
R
--
D
VLA
G
R
Q
P
D
I
Q
V
N
VD
A
TRM
S
Q
A
F
T
GN
GYIQ
N
I
INGEV
N
SFVA
R
YR-
-
D
NSE
P
LV
SL
ETR
M
R
F
NPNLD
PA
WF
-
-
G
G
V
M
AII
NN
I
TM
LAI
VLT
G
SAL
I
RERE
H
GTV
EH
LLV
M
P
I
T
PF
EI
M
M
A
K
V
WSM
G
L
V
V
L
V
V
SG
L
SLV
LM
VK---G
V
L
GVP
IE
GS
IP
LF
M
L
GVA
L
S
LFAT
T
S
I
G
IFMG
T
IAR
S
M
P
Q
L
GL
L
V
I
L
V
-
LLP
L
QM
LSG
GST
P
R
ESMP
---
Q
T
VQD
IMLTM
PT
T
HF
VS
L
AQ
A
I
LY
R
G
A
G
F
E
IVW
PQ
F
L
T
L
M
A
IGGAFFTIA
L
LRFRKTI
fig|656380.3.peg.4576
Escherichia coli FVEC1412 (13-370/374)
KEL
R
SLL
G
D
-
--------KA
M
L
T
LIVF
S
F
TV
SV
YSSATVTPG
S
L
N
L
A
P
I
S
I
A
D
M
DQ
SQL
S
NRI
V
NS
F
Y
R
PWF
L
--P
P
E
M
I
T
A
DEMD
AG
LDAG
RY
T
F
AI
N
IPPNF
Q
R
--
D
VLA
G
R
Q
P
D
I
Q
V
N
VD
A
TRM
S
Q
A
F
T
GN
GYIQ
N
I
INGEV
N
SFVA
R
YR-
-
D
NSE
P
LV
SL
ETR
M
R
F
NPNLD
PA
WF
-
-
G
G
V
M
AII
NN
I
TM
LAI
VLT
G
SAL
I
RERE
H
GTV
EH
LLV
M
P
I
T
PF
EI
M
M
A
K
V
WSM
G
L
V
V
L
V
V
SG
L
SLV
LM
VK---G
V
L
GVP
IE
GS
IP
LF
M
L
GVA
L
S
LFAT
T
S
I
G
IFMG
T
IAR
S
M
P
Q
L
GL
L
V
I
L
V
-
LLP
L
QM
LSG
GST
P
R
ESMP
---
Q
T
VQD
IMLTM
PT
T
HF
VS
L
AQ
A
I
LY
R
G
A
G
F
E
IVW
PQ
F
L
T
L
M
A
IGGAFFTIA
L
LRFRKTI
fig|749549.3.peg.2761
Escherichia coli MS 198-1 (13-370/374)
KEL
R
SLL
G
D
-
--------KA
M
L
T
LIVF
S
F
TV
SV
YSSATVTPG
S
L
N
L
A
P
I
S
I
A
D
M
DQ
SQL
S
NRI
V
NS
F
Y
R
PWF
L
--P
P
E
M
I
T
A
DEMD
AG
LDAG
RY
T
F
AI
N
IPPNF
Q
R
--
D
VLA
G
R
Q
P
D
I
Q
V
N
VD
A
TRM
S
Q
A
F
T
GN
GYIQ
N
I
INGEV
N
SFVA
R
YR-
-
D
NSE
P
LV
SL
ETR
M
R
F
NPNLD
PA
WF
-
-
G
G
V
M
AII
NN
I
TM
LAI
VLT
G
SAL
I
RERE
H
GTV
EH
LLV
M
P
I
T
PF
EI
M
M
A
K
V
WSM
G
L
V
V
L
V
V
SG
L
SLV
LM
VK---G
V
L
GVP
IE
GS
IP
LF
M
L
GVA
L
S
LFAT
T
S
I
G
IFMG
T
IAR
S
M
P
Q
L
GL
L
V
I
L
V
-
LLP
L
QM
LSG
GST
P
R
ESMP
---
Q
T
VQD
IMLTM
PT
T
HF
VS
L
AQ
A
I
LY
R
G
A
G
F
E
IVW
PQ
F
L
T
L
M
A
IGGAFFTIA
L
LRFRKTI
fig|585056.7.peg.4144
Escherichia coli UMN026 (13-370/374)
KEL
R
SLL
G
D
-
--------KA
M
L
T
LIVF
S
F
TV
SV
YSSATVTPG
S
L
N
L
A
P
I
S
I
A
D
M
DQ
SQL
S
NRI
V
NS
F
Y
R
PWF
L
--P
P
E
M
I
T
A
DEMD
AG
LDAG
RY
T
F
AI
N
IPPNF
Q
R
--
D
VLA
G
R
Q
P
D
I
Q
V
N
VD
A
TRM
S
Q
A
F
T
GN
GYIQ
N
I
INGEV
N
SFVA
R
YR-
-
D
NSE
P
LV
SL
ETR
M
R
F
NPNLD
PA
WF
-
-
G
G
V
M
AII
NN
I
TM
LAI
VLT
G
SAL
I
RERE
H
GTV
EH
LLV
M
P
I
T
PF
EI
M
M
A
K
V
WSM
G
L
V
V
L
V
V
SG
L
SLV
LM
VK---G
V
L
GVP
IE
GS
IP
LF
M
L
GVA
L
S
LFAT
T
S
I
G
IFMG
T
IAR
S
M
P
Q
L
GL
L
V
I
L
V
-
LLP
L
QM
LSG
GST
P
R
ESMP
---
Q
T
VQD
IMLTM
PT
T
HF
VS
L
AQ
A
I
LY
R
G
A
G
F
E
IVW
PQ
F
L
T
L
M
A
IGGAFFTIA
L
LRFRKTI
Consen1
Primary consensus
MfhRLfslsRkEl
sLlrdp
mi
livf
f
sv
---------
v
na
iAi
D
Dq
S
t
f
r
f
p
l
s
dEmd
ldag
t
ai
iPpnF
R
--
D
g
p
dl
v
vDg
s
A
t
gYiQ
i
q
r
p
nse
lv
etR
ryNPnld
wf
vp
viaii
--
tm
vlt
lsv
RErE
Gtv
LlV
P
T
ei
mgK
---
lp
l
v
l
lm
v
gvP
GS
lf
l
ly
tg
Gllist
sq
qa
gv
l
-
llPa
lSG
Pvesmp
---
wvqd
Pt
HF
iaq
i
k
a
l
ivW
f
pLl
IggafftiAylrFRktiM
Consen2
Secondary consensus
lr
wtyi
r
a
e
rge
-
l
l
m
y
t
yssatvtpg
l
ll
f
v
n
v
l
g
l
l
m
t
q
r
rtq
l
lv
f
ad
kl
t
q
i
-
a
n
i
n
m
n
g
-
sqs
vm
--
wf
dvk
pa
-
g
lmp
lnn
mi
vs
sal
k
s
y
qf
a
wsm
vv
i
l
f
i
a
qi
tl
f
is
vs
ifmgs
tm
al
lt
tm
l
f
ranlegpg
m
g
i
lt
t
r
l
f
dl
l
t
m
tattgsa
lam
rkv
Consensus 1
(when a gap)
Conservative difference
Consensus 2
(when a gap)
Nonconservative diff.
Other character