fig|1040638.4.peg.4880
Escherichia coli O104:H4 str. LB226692
MTS
P
LP
V
Y
P
V
A
---
--S
AEG
CE
L
I
L
S
D
G
RR
L
VD
GMS
SW
WAAIH
G
Y
N
HP
Q
L
N
AA
M
-
K
S
Q
IDAMS
H
VMFGGITH
A
PA
I
E
L
C
R
K
L
VAMT
P
QPL-EC
V
FLAD
SGS
V
A
V
E
V
A
M
K
M
A
L
QYWQAKGEA
-
R
QRF
L
T
F
R
N
G
YHG
D
T
--------
FG
A
MS
V
CDPDNS
M
HSLWK
G
YL
P
E
N
LFAPAPQSRMDGEWDERDMVGFARLMA-
-
AHRHEI
AA
V
I
I
EP
IV
QG
A
GG
MRMYH
PE
W
L
KR
I
R
K
M
CD
R
E
GILLI
A
DE
I
AT
G
FG
RTG
K
LFA
CEHAEIA
PD
I
L
C
L
G
K
A
L
T
GG
T
M
T
L
S
A
TL
T
T
R
EV
A
E
T
IS
N
G
E
AG
CFMH
G
P
T
FM
GNPLA
C
AAA
N
A
S
L
AILESGDWQ
Q
QVAAIEV
Q
L
R
E
Q
L
AP
A
R
D
A-EMVA
DVR
V
LG
QSA
fig|6666666.5357.peg.938
Escherichia coli TY-2482 (1-344/410)
MTS
P
LP
V
Y
P
V
A
---
--S
AEG
CE
L
I
L
S
D
G
RR
L
VD
GMS
SW
WAAIH
G
Y
N
HP
Q
L
N
AA
M
-
K
S
Q
IDAMS
H
VMFGGITH
A
PA
I
E
L
C
R
K
L
VAMT
P
QPL-EC
V
FLAD
SGS
V
A
V
E
V
A
M
K
M
A
L
QYWQAKGEA
-
R
QRF
L
T
F
R
N
G
YHG
D
T
--------
FG
A
MS
V
CDPDNS
M
HSLWK
G
YL
P
E
N
LFAPAPQSRMDGEWDERDMVGFARLMA-
-
AHRHEI
AA
V
I
I
EP
IV
QG
A
GG
MRMYH
PE
W
L
KR
I
R
K
M
CD
R
E
GILLI
A
DE
I
AT
G
FG
RTG
K
LFA
CEHAEIA
PD
I
L
C
L
G
K
A
L
T
GG
T
M
T
L
S
A
TL
T
T
R
EV
A
E
T
IS
N
G
E
AG
CFMH
G
P
T
FM
GNPLA
C
AAA
N
A
S
L
AILESGDWQ
Q
QVAAIEV
Q
L
R
E
Q
L
AP
A
R
D
A-EMVA
DVR
V
LG
fig|585055.6.peg.826
Escherichia coli 55989 (1-344/410)
MTS
P
LP
V
Y
P
V
A
---
--S
AEG
CE
L
I
L
S
D
G
RR
L
VD
GMS
SW
WAAIH
G
Y
N
HP
Q
L
N
AA
M
-
K
S
Q
IDAMS
H
VMFGGITH
A
PA
I
E
L
C
R
K
L
VAMT
P
QPL-EC
V
FLAD
SGS
V
A
V
E
V
A
M
K
M
A
L
QYWQAKGEA
-
R
QRF
L
T
F
R
N
G
YHG
D
T
--------
FG
A
MS
V
CDPDNS
M
HSLWK
G
YL
P
E
N
LFAPAPQSRMDGEWDERDMVGFARLMA-
-
AHRHEI
AA
V
I
I
EP
IV
QG
A
GG
MRMYH
PE
W
L
KR
I
R
K
M
CD
R
E
GILLI
A
DE
I
AT
G
FG
RTG
K
LFA
CEHAEIA
PD
I
L
C
L
G
K
A
L
T
GG
T
M
T
L
S
A
TL
T
T
R
EV
A
E
T
IS
N
G
E
AG
CFMH
G
P
T
FM
GNPLA
C
AAA
N
A
S
L
AILESGDWQ
Q
QVAAIEV
Q
L
R
E
Q
L
AP
A
R
D
A-EMVA
DVR
V
LG
fig|585055.8.peg.830
Escherichia coli 55989 (1-344/410)
MTS
P
LP
V
Y
P
V
A
---
--S
AEG
CE
L
I
L
S
D
G
RR
L
VD
GMS
SW
WAAIH
G
Y
N
HP
Q
L
N
AA
M
-
K
S
Q
IDAMS
H
VMFGGITH
A
PA
I
E
L
C
R
K
L
VAMT
P
QPL-EC
V
FLAD
SGS
V
A
V
E
V
A
M
K
M
A
L
QYWQAKGEA
-
R
QRF
L
T
F
R
N
G
YHG
D
T
--------
FG
A
MS
V
CDPDNS
M
HSLWK
G
YL
P
E
N
LFAPAPQSRMDGEWDERDMVGFARLMA-
-
AHRHEI
AA
V
I
I
EP
IV
QG
A
GG
MRMYH
PE
W
L
KR
I
R
K
M
CD
R
E
GILLI
A
DE
I
AT
G
FG
RTG
K
LFA
CEHAEIA
PD
I
L
C
L
G
K
A
L
T
GG
T
M
T
L
S
A
TL
T
T
R
EV
A
E
T
IS
N
G
E
AG
CFMH
G
P
T
FM
GNPLA
C
AAA
N
A
S
L
AILESGDWQ
Q
QVAAIEV
Q
L
R
E
Q
L
AP
A
R
D
A-EMVA
DVR
V
LG
fig|585396.4.peg.869
Escherichia coli O111:H- str. 11128 (1-344/410)
MTS
P
LP
V
Y
P
V
A
---
--S
AEG
CE
L
I
L
S
D
G
RR
L
VD
GMS
SW
WAAIH
G
Y
N
HP
Q
L
N
AA
M
-
K
S
Q
IDAMS
H
VMFGGITH
A
PA
I
E
L
C
R
K
L
VAMT
P
QPL-EC
V
FLAD
SGS
V
A
V
E
V
A
M
K
M
A
L
QYWQAKGEA
-
R
QRF
L
T
F
R
N
G
YHG
D
T
--------
FG
A
MS
V
CDPDNS
M
HSLWK
G
YL
P
E
N
LFAPAPQSRMDGEWDERDMVGFARLMA-
-
AHRHEI
AA
V
I
I
EP
IV
QG
A
GG
MRMYH
PE
W
L
KR
I
R
K
M
CD
R
E
GILLI
A
DE
I
AT
G
FG
RTG
K
LFA
CEHAEIA
PD
I
L
C
L
G
K
A
L
T
GG
T
M
T
L
S
A
TL
T
T
R
EV
A
E
T
IS
N
G
E
AG
CFMH
G
P
T
FM
GNPLA
C
AAA
N
A
S
L
AILESGDWQ
Q
QVAAIEV
Q
L
R
E
Q
L
AP
A
R
D
A-EMVA
DVR
V
LG
fig|573235.3.peg.915
Escherichia coli O26:H11 str. 11368 (1-344/410)
MTS
P
LP
V
Y
P
V
A
---
--S
AEG
CE
L
I
L
S
D
G
RR
L
VD
GMS
SW
WAAIH
G
Y
N
HP
Q
L
N
AA
M
-
K
S
Q
IDAMS
H
VMFGGITH
A
PA
I
E
L
C
R
K
L
VAMT
P
QPL-EC
V
FLAD
SGS
V
A
V
E
V
A
M
K
M
A
L
QYWQAKGEA
-
R
QRF
L
T
F
R
N
G
YHG
D
T
--------
FG
A
MS
V
CDPDNS
M
HSLWK
G
YL
P
E
N
LFAPAPQSRMDGEWDERDMVGFARLMA-
-
AHRHEI
AA
V
I
I
EP
IV
QG
A
GG
MRMYH
PE
W
L
KR
I
R
K
M
CD
R
E
GILLI
A
DE
I
AT
G
FG
RTG
K
LFA
CEHAEIA
PD
I
L
C
L
G
K
A
L
T
GG
T
M
T
L
S
A
TL
T
T
R
EV
A
E
T
IS
N
G
E
AG
CFMH
G
P
T
FM
GNPLA
C
AAA
N
A
S
L
AILESGDWQ
Q
QVAAIEV
Q
L
R
E
Q
L
AP
A
R
D
A-EMVA
DVR
V
LG
fig|656419.3.peg.1055
Escherichia coli M718 (1-344/410)
MTS
P
LP
V
Y
P
V
A
---
--S
AEG
CE
L
I
L
S
D
G
RR
L
VD
GMS
SW
WAAIH
G
Y
N
HP
Q
L
N
AA
M
-
K
T
Q
IDAMS
H
VMFGGITH
A
PA
I
E
L
C
R
K
L
VAMT
P
QPL-EC
V
FLAD
SGS
V
A
V
E
V
A
M
K
M
A
L
QYWQAKGEA
-
R
QRF
L
T
F
R
N
G
YHG
D
T
--------
FG
A
MS
V
CDPDNS
M
HSLWK
G
YL
P
E
N
LFAPAPQSRMDGEWDERDMVGFARLMA-
-
AHRHEI
AA
V
I
I
EP
IV
QG
A
GG
MRMYH
PE
W
L
KR
I
R
K
M
CD
R
E
GILLI
A
DE
I
AT
G
FG
RTG
K
LFA
CEHAEIA
PD
I
L
C
L
G
K
A
L
T
GG
T
M
T
L
S
A
TL
T
T
R
EV
A
E
T
IS
N
G
E
AG
CFMH
G
P
T
FM
GNPLA
C
AAA
N
A
S
L
AILESGDWQ
Q
QVAAIEV
Q
L
R
E
Q
L
AP
A
R
D
A-EMVA
DVR
V
LG
fig|656408.3.peg.773
Escherichia coli H591 (1-344/410)
MTS
P
LP
V
Y
P
V
A
---
--S
AEG
CE
L
I
L
S
D
G
RR
L
VD
GMS
SW
WAAIH
G
Y
N
HP
Q
L
N
AA
M
-
K
S
Q
IDAMS
H
VMFGGITH
A
PA
I
E
L
C
R
K
L
VAMT
P
QPL-EC
V
FLAD
SGS
V
A
V
E
V
A
M
K
M
A
L
QYWQAKGEA
-
R
HRF
L
T
F
R
N
G
YHG
D
T
--------
FG
A
MS
V
CDPDNS
M
HSLWK
G
YL
P
E
N
LFAPAPQSRMDGEWDERDMVGFARLMA-
-
AHRHEI
AA
V
I
I
EP
IV
QG
A
GG
MRMYH
PE
W
L
KR
I
R
K
M
CD
R
E
GILLI
A
DE
I
AT
G
FG
RTG
K
LFA
CEHAEIA
PD
I
L
C
L
G
K
A
L
T
GG
T
M
T
L
S
A
TL
T
T
R
EV
A
E
T
IS
N
G
E
AG
CFMH
G
P
T
FM
GNPLA
C
AAA
N
A
S
L
AILESGDWQ
Q
QVAAIEV
Q
L
R
E
Q
L
AP
A
R
D
A-EMVA
DVR
V
LG
fig|679206.4.peg.2715
Escherichia coli MS 119-7 (1-344/410)
MTS
P
LP
V
Y
P
V
A
---
--S
AEG
CE
L
I
L
S
D
G
RR
L
VD
GMS
SW
WAAIH
G
Y
N
HP
Q
L
N
AA
M
-
K
S
Q
IDAMS
H
VMFGGITH
A
PA
I
E
L
C
R
K
L
VAMT
P
QPL-EC
V
FLAD
SGS
V
A
V
E
V
A
M
K
M
A
L
QYWQAKGEA
-
R
HRF
L
T
F
R
N
G
YHG
D
T
--------
FG
A
MS
V
CDPDNS
M
HSLWK
G
YL
P
E
N
LFAPAPQSRMDGEWDERDMVGFARLMA-
-
AHRHEI
AA
V
I
I
EP
IV
QG
A
GG
MRMYH
PE
W
L
KR
I
R
K
M
CD
R
E
GILLI
A
DE
I
AT
G
FG
RTG
K
LFA
CEHAEIA
PD
I
L
C
L
G
K
A
L
T
GG
T
M
T
L
S
A
TL
T
T
R
EV
A
E
T
IS
N
G
E
AG
CFMH
G
P
T
FM
GNPLA
C
AAA
N
A
S
L
AILESGDWQ
Q
QVAAIEV
Q
L
R
E
Q
L
AP
A
R
D
A-EMVA
DVR
V
LG
fig|656443.3.peg.1042
Escherichia coli TA271 (1-344/410)
MTS
P
LP
V
Y
P
V
A
---
--S
AEG
CE
L
I
L
S
D
G
RR
L
VD
GMS
SW
WAAIH
G
Y
N
HP
Q
L
N
AA
M
-
K
S
Q
IDAMS
H
VMFGGITH
A
PA
I
E
L
C
R
K
L
VAMT
P
QPL-EC
V
FLAD
SGS
V
A
V
E
V
A
M
K
M
A
L
QYWQAKGEA
-
R
HRF
L
T
F
R
N
G
YHG
D
T
--------
FG
A
MS
V
CDPDNS
M
HSLWK
G
YL
P
E
N
LFAPAPQSRMDGEWDERDMVGFARLMA-
-
AHRHEI
AA
V
I
I
EP
IV
QG
A
GG
MRMYH
PE
W
L
KR
I
R
K
M
CD
R
E
GILLI
A
DE
I
AT
G
FG
RTG
K
LFA
CEHAEIA
PD
I
L
C
L
G
K
A
L
T
GG
T
M
T
L
S
A
TL
T
T
R
EV
A
E
T
IS
N
G
E
AG
CFMH
G
P
T
FM
GNPLA
C
AAA
N
A
S
L
AILESGDWQ
Q
QVAAIEV
Q
L
R
E
Q
L
AP
A
R
D
A-EMVA
DVR
V
LG
fig|562.371.peg.47
Escherichia coli 1044A (1-344/410)
MTS
P
LP
V
Y
P
V
A
---
--S
AEG
CE
L
I
L
S
D
G
RR
L
VD
GMS
SW
WAAIH
G
Y
N
HP
Q
L
N
AA
M
-
K
S
Q
IDAMS
H
VMFGGITH
A
PA
I
E
L
C
R
K
L
VAMT
P
QPL-EC
V
FLAD
SGS
V
A
V
E
V
A
M
K
M
A
L
QYWQAKGEA
-
R
QHF
L
T
F
R
N
G
YHG
D
T
--------
FG
A
MS
V
CDPDNS
M
HSLWK
G
YL
P
E
N
LFAPAPQSRMDGEWDERDMVGFARLMA-
-
AHRHEI
AA
V
I
I
EP
IV
QG
A
GG
MRMYH
PE
W
L
KR
I
R
K
M
CD
R
E
GILLI
A
DE
I
AT
G
FG
RTG
K
LFA
CEHAEIA
PD
I
L
C
L
G
K
A
L
T
GG
T
M
T
L
S
A
TL
T
T
R
EV
A
E
T
IS
N
G
E
AG
CFMH
G
P
T
FM
GNPLA
C
AAA
N
A
S
L
AILESGDWQ
Q
QVAAIEV
Q
L
R
E
Q
L
AP
A
R
D
A-EMVA
DVR
V
LG
fig|562.373.peg.1263
Escherichia coli 1125A (1-344/410)
MTS
P
LP
V
Y
P
V
A
---
--S
AEG
CE
L
I
L
S
D
G
RR
L
VD
GMS
SW
WAAIH
G
Y
N
HP
Q
L
N
AA
M
-
K
S
Q
IDAMS
H
VMFGGITH
A
PA
I
E
L
C
R
K
L
VAMT
P
QPL-EC
V
FLAD
SGS
V
A
V
E
V
A
M
K
M
A
L
QYWQAKGEA
-
R
QHF
L
T
F
R
N
G
YHG
D
T
--------
FG
A
MS
V
CDPDNS
M
HSLWK
G
YL
P
E
N
LFAPAPQSRMDGEWDERDMVGFARLMA-
-
AHRHEI
AA
V
I
I
EP
IV
QG
A
GG
MRMYH
PE
W
L
KR
I
R
K
M
CD
R
E
GILLI
A
DE
I
AT
G
FG
RTG
K
LFA
CEHAEIA
PD
I
L
C
L
G
K
A
L
T
GG
T
M
T
L
S
A
TL
T
T
R
EV
A
E
T
IS
N
G
E
AG
CFMH
G
P
T
FM
GNPLA
C
AAA
N
A
S
L
AILESGDWQ
Q
QVAAIEV
Q
L
R
E
Q
L
AP
A
R
D
A-EMVA
DVR
V
LG
fig|562.372.peg.1129
Escherichia coli 1212A (1-344/410)
MTS
P
LP
V
Y
P
V
A
---
--S
AEG
CE
L
I
L
S
D
G
RR
L
VD
GMS
SW
WAAIH
G
Y
N
HP
Q
L
N
AA
M
-
K
S
Q
IDAMS
H
VMFGGITH
A
PA
I
E
L
C
R
K
L
VAMT
P
QPL-EC
V
FLAD
SGS
V
A
V
E
V
A
M
K
M
A
L
QYWQAKGEA
-
R
QHF
L
T
F
R
N
G
YHG
D
T
--------
FG
A
MS
V
CDPDNS
M
HSLWK
G
YL
P
E
N
LFAPAPQSRMDGEWDERDMVGFARLMA-
-
AHRHEI
AA
V
I
I
EP
IV
QG
A
GG
MRMYH
PE
W
L
KR
I
R
K
M
CD
R
E
GILLI
A
DE
I
AT
G
FG
RTG
K
LFA
CEHAEIA
PD
I
L
C
L
G
K
A
L
T
GG
T
M
T
L
S
A
TL
T
T
R
EV
A
E
T
IS
N
G
E
AG
CFMH
G
P
T
FM
GNPLA
C
AAA
N
A
S
L
AILESGDWQ
Q
QVAAIEV
Q
L
R
E
Q
L
AP
A
R
D
A-EMVA
DVR
V
LG
fig|562.374.peg.2662
Escherichia coli 536A (1-344/410)
MTS
P
LP
V
Y
P
V
A
---
--S
AEG
CE
L
I
L
S
D
G
RR
L
VD
GMS
SW
WAAIH
G
Y
N
HP
Q
L
N
AA
M
-
K
S
Q
IDAMS
H
VMFGGITH
A
PA
I
E
L
C
R
K
L
VAMT
P
QPL-EC
V
FLAD
SGS
V
A
V
E
V
A
M
K
M
A
L
QYWQAKGEA
-
R
QHF
L
T
F
R
N
G
YHG
D
T
--------
FG
A
MS
V
CDPDNS
M
HSLWK
G
YL
P
E
N
LFAPAPQSRMDGEWDERDMVGFARLMA-
-
AHRHEI
AA
V
I
I
EP
IV
QG
A
GG
MRMYH
PE
W
L
KR
I
R
K
M
CD
R
E
GILLI
A
DE
I
AT
G
FG
RTG
K
LFA
CEHAEIA
PD
I
L
C
L
G
K
A
L
T
GG
T
M
T
L
S
A
TL
T
T
R
EV
A
E
T
IS
N
G
E
AG
CFMH
G
P
T
FM
GNPLA
C
AAA
N
A
S
L
AILESGDWQ
Q
QVAAIEV
Q
L
R
E
Q
L
AP
A
R
D
A-EMVA
DVR
V
LG
fig|444454.5.peg.5343
Escherichia coli O157:H7 str. EC4024 (1-344/410)
MTS
P
LP
V
Y
P
V
A
---
--S
AEG
CE
L
I
L
S
D
G
RR
L
VD
GMS
SW
WAAIH
G
Y
N
HP
Q
L
N
AA
M
-
K
S
Q
IDAMS
H
VMFGGITH
A
PA
I
E
L
C
R
K
L
VAMT
P
QPL-EC
V
FLAD
SGS
V
A
V
E
V
A
M
K
M
A
L
QYWQAKGEA
-
R
QHF
L
T
F
R
N
G
YHG
D
T
--------
FG
A
MS
V
CDPDNS
M
HSLWK
G
YL
P
E
N
LFAPAPQSRMDGEWDERDMVGFARLMA-
-
AHRHEI
AA
V
I
I
EP
IV
QG
A
GG
MRMYH
PE
W
L
KR
I
R
K
M
CD
R
E
GILLI
A
DE
I
AT
G
FG
RTG
K
LFA
CEHAEIA
PD
I
L
C
L
G
K
A
L
T
GG
T
M
T
L
S
A
TL
T
T
R
EV
A
E
T
IS
N
G
E
AG
CFMH
G
P
T
FM
GNPLA
C
AAA
N
A
S
L
AILESGDWQ
Q
QVAAIEV
Q
L
R
E
Q
L
AP
A
R
D
A-EMVA
DVR
V
LG
fig|444449.5.peg.4276
Escherichia coli O157:H7 str. EC4042 (1-344/410)
MTS
P
LP
V
Y
P
V
A
---
--S
AEG
CE
L
I
L
S
D
G
RR
L
VD
GMS
SW
WAAIH
G
Y
N
HP
Q
L
N
AA
M
-
K
S
Q
IDAMS
H
VMFGGITH
A
PA
I
E
L
C
R
K
L
VAMT
P
QPL-EC
V
FLAD
SGS
V
A
V
E
V
A
M
K
M
A
L
QYWQAKGEA
-
R
QHF
L
T
F
R
N
G
YHG
D
T
--------
FG
A
MS
V
CDPDNS
M
HSLWK
G
YL
P
E
N
LFAPAPQSRMDGEWDERDMVGFARLMA-
-
AHRHEI
AA
V
I
I
EP
IV
QG
A
GG
MRMYH
PE
W
L
KR
I
R
K
M
CD
R
E
GILLI
A
DE
I
AT
G
FG
RTG
K
LFA
CEHAEIA
PD
I
L
C
L
G
K
A
L
T
GG
T
M
T
L
S
A
TL
T
T
R
EV
A
E
T
IS
N
G
E
AG
CFMH
G
P
T
FM
GNPLA
C
AAA
N
A
S
L
AILESGDWQ
Q
QVAAIEV
Q
L
R
E
Q
L
AP
A
R
D
A-EMVA
DVR
V
LG
fig|444448.5.peg.3553
Escherichia coli O157:H7 str. EC4045 (1-344/410)
MTS
P
LP
V
Y
P
V
A
---
--S
AEG
CE
L
I
L
S
D
G
RR
L
VD
GMS
SW
WAAIH
G
Y
N
HP
Q
L
N
AA
M
-
K
S
Q
IDAMS
H
VMFGGITH
A
PA
I
E
L
C
R
K
L
VAMT
P
QPL-EC
V
FLAD
SGS
V
A
V
E
V
A
M
K
M
A
L
QYWQAKGEA
-
R
QHF
L
T
F
R
N
G
YHG
D
T
--------
FG
A
MS
V
CDPDNS
M
HSLWK
G
YL
P
E
N
LFAPAPQSRMDGEWDERDMVGFARLMA-
-
AHRHEI
AA
V
I
I
EP
IV
QG
A
GG
MRMYH
PE
W
L
KR
I
R
K
M
CD
R
E
GILLI
A
DE
I
AT
G
FG
RTG
K
LFA
CEHAEIA
PD
I
L
C
L
G
K
A
L
T
GG
T
M
T
L
S
A
TL
T
T
R
EV
A
E
T
IS
N
G
E
AG
CFMH
G
P
T
FM
GNPLA
C
AAA
N
A
S
L
AILESGDWQ
Q
QVAAIEV
Q
L
R
E
Q
L
AP
A
R
D
A-EMVA
DVR
V
LG
fig|444453.5.peg.895
Escherichia coli O157:H7 str. EC4076 (1-344/410)
MTS
P
LP
V
Y
P
V
A
---
--S
AEG
CE
L
I
L
S
D
G
RR
L
VD
GMS
SW
WAAIH
G
Y
N
HP
Q
L
N
AA
M
-
K
S
Q
IDAMS
H
VMFGGITH
A
PA
I
E
L
C
R
K
L
VAMT
P
QPL-EC
V
FLAD
SGS
V
A
V
E
V
A
M
K
M
A
L
QYWQAKGEA
-
R
QHF
L
T
F
R
N
G
YHG
D
T
--------
FG
A
MS
V
CDPDNS
M
HSLWK
G
YL
P
E
N
LFAPAPQSRMDGEWDERDMVGFARLMA-
-
AHRHEI
AA
V
I
I
EP
IV
QG
A
GG
MRMYH
PE
W
L
KR
I
R
K
M
CD
R
E
GILLI
A
DE
I
AT
G
FG
RTG
K
LFA
CEHAEIA
PD
I
L
C
L
G
K
A
L
T
GG
T
M
T
L
S
A
TL
T
T
R
EV
A
E
T
IS
N
G
E
AG
CFMH
G
P
T
FM
GNPLA
C
AAA
N
A
S
L
AILESGDWQ
Q
QVAAIEV
Q
L
R
E
Q
L
AP
A
R
D
A-EMVA
DVR
V
LG
fig|444452.5.peg.3284
Escherichia coli O157:H7 str. EC4113 (1-344/410)
MTS
P
LP
V
Y
P
V
A
---
--S
AEG
CE
L
I
L
S
D
G
RR
L
VD
GMS
SW
WAAIH
G
Y
N
HP
Q
L
N
AA
M
-
K
S
Q
IDAMS
H
VMFGGITH
A
PA
I
E
L
C
R
K
L
VAMT
P
QPL-EC
V
FLAD
SGS
V
A
V
E
V
A
M
K
M
A
L
QYWQAKGEA
-
R
QHF
L
T
F
R
N
G
YHG
D
T
--------
FG
A
MS
V
CDPDNS
M
HSLWK
G
YL
P
E
N
LFAPAPQSRMDGEWDERDMVGFARLMA-
-
AHRHEI
AA
V
I
I
EP
IV
QG
A
GG
MRMYH
PE
W
L
KR
I
R
K
M
CD
R
E
GILLI
A
DE
I
AT
G
FG
RTG
K
LFA
CEHAEIA
PD
I
L
C
L
G
K
A
L
T
GG
T
M
T
L
S
A
TL
T
T
R
EV
A
E
T
IS
N
G
E
AG
CFMH
G
P
T
FM
GNPLA
C
AAA
N
A
S
L
AILESGDWQ
Q
QVAAIEV
Q
L
R
E
Q
L
AP
A
R
D
A-EMVA
DVR
V
LG
fig|444450.8.peg.1010
Escherichia coli O157:H7 str. EC4115 (1-344/410)
MTS
P
LP
V
Y
P
V
A
---
--S
AEG
CE
L
I
L
S
D
G
RR
L
VD
GMS
SW
WAAIH
G
Y
N
HP
Q
L
N
AA
M
-
K
S
Q
IDAMS
H
VMFGGITH
A
PA
I
E
L
C
R
K
L
VAMT
P
QPL-EC
V
FLAD
SGS
V
A
V
E
V
A
M
K
M
A
L
QYWQAKGEA
-
R
QHF
L
T
F
R
N
G
YHG
D
T
--------
FG
A
MS
V
CDPDNS
M
HSLWK
G
YL
P
E
N
LFAPAPQSRMDGEWDERDMVGFARLMA-
-
AHRHEI
AA
V
I
I
EP
IV
QG
A
GG
MRMYH
PE
W
L
KR
I
R
K
M
CD
R
E
GILLI
A
DE
I
AT
G
FG
RTG
K
LFA
CEHAEIA
PD
I
L
C
L
G
K
A
L
T
GG
T
M
T
L
S
A
TL
T
T
R
EV
A
E
T
IS
N
G
E
AG
CFMH
G
P
T
FM
GNPLA
C
AAA
N
A
S
L
AILESGDWQ
Q
QVAAIEV
Q
L
R
E
Q
L
AP
A
R
D
A-EMVA
DVR
V
LG
fig|444451.5.peg.3939
Escherichia coli O157:H7 str. EC4196 (1-344/410)
MTS
P
LP
V
Y
P
V
A
---
--S
AEG
CE
L
I
L
S
D
G
RR
L
VD
GMS
SW
WAAIH
G
Y
N
HP
Q
L
N
AA
M
-
K
S
Q
IDAMS
H
VMFGGITH
A
PA
I
E
L
C
R
K
L
VAMT
P
QPL-EC
V
FLAD
SGS
V
A
V
E
V
A
M
K
M
A
L
QYWQAKGEA
-
R
QHF
L
T
F
R
N
G
YHG
D
T
--------
FG
A
MS
V
CDPDNS
M
HSLWK
G
YL
P
E
N
LFAPAPQSRMDGEWDERDMVGFARLMA-
-
AHRHEI
AA
V
I
I
EP
IV
QG
A
GG
MRMYH
PE
W
L
KR
I
R
K
M
CD
R
E
GILLI
A
DE
I
AT
G
FG
RTG
K
LFA
CEHAEIA
PD
I
L
C
L
G
K
A
L
T
GG
T
M
T
L
S
A
TL
T
T
R
EV
A
E
T
IS
N
G
E
AG
CFMH
G
P
T
FM
GNPLA
C
AAA
N
A
S
L
AILESGDWQ
Q
QVAAIEV
Q
L
R
E
Q
L
AP
A
R
D
A-EMVA
DVR
V
LG
fig|444447.5.peg.3742
Escherichia coli O157:H7 str. EC4206 (1-344/410)
MTS
P
LP
V
Y
P
V
A
---
--S
AEG
CE
L
I
L
S
D
G
RR
L
VD
GMS
SW
WAAIH
G
Y
N
HP
Q
L
N
AA
M
-
K
S
Q
IDAMS
H
VMFGGITH
A
PA
I
E
L
C
R
K
L
VAMT
P
QPL-EC
V
FLAD
SGS
V
A
V
E
V
A
M
K
M
A
L
QYWQAKGEA
-
R
QHF
L
T
F
R
N
G
YHG
D
T
--------
FG
A
MS
V
CDPDNS
M
HSLWK
G
YL
P
E
N
LFAPAPQSRMDGEWDERDMVGFARLMA-
-
AHRHEI
AA
V
I
I
EP
IV
QG
A
GG
MRMYH
PE
W
L
KR
I
R
K
M
CD
R
E
GILLI
A
DE
I
AT
G
FG
RTG
K
LFA
CEHAEIA
PD
I
L
C
L
G
K
A
L
T
GG
T
M
T
L
S
A
TL
T
T
R
EV
A
E
T
IS
N
G
E
AG
CFMH
G
P
T
FM
GNPLA
C
AAA
N
A
S
L
AILESGDWQ
Q
QVAAIEV
Q
L
R
E
Q
L
AP
A
R
D
A-EMVA
DVR
V
LG
fig|478004.5.peg.3801
Escherichia coli O157:H7 str. EC4401 (1-344/410)
MTS
P
LP
V
Y
P
V
A
---
--S
AEG
CE
L
I
L
S
D
G
RR
L
VD
GMS
SW
WAAIH
G
Y
N
HP
Q
L
N
AA
M
-
K
S
Q
IDAMS
H
VMFGGITH
A
PA
I
E
L
C
R
K
L
VAMT
P
QPL-EC
V
FLAD
SGS
V
A
V
E
V
A
M
K
M
A
L
QYWQAKGEA
-
R
QHF
L
T
F
R
N
G
YHG
D
T
--------
FG
A
MS
V
CDPDNS
M
HSLWK
G
YL
P
E
N
LFAPAPQSRMDGEWDERDMVGFARLMA-
-
AHRHEI
AA
V
I
I
EP
IV
QG
A
GG
MRMYH
PE
W
L
KR
I
R
K
M
CD
R
E
GILLI
A
DE
I
AT
G
FG
RTG
K
LFA
CEHAEIA
PD
I
L
C
L
G
K
A
L
T
GG
T
M
T
L
S
A
TL
T
T
R
EV
A
E
T
IS
N
G
E
AG
CFMH
G
P
T
FM
GNPLA
C
AAA
N
A
S
L
AILESGDWQ
Q
QVAAIEV
Q
L
R
E
Q
L
AP
A
R
D
A-EMVA
DVR
V
LG
fig|478006.5.peg.3814
Escherichia coli O157:H7 str. EC4501 (1-344/410)
MTS
P
LP
V
Y
P
V
A
---
--S
AEG
CE
L
I
L
S
D
G
RR
L
VD
GMS
SW
WAAIH
G
Y
N
HP
Q
L
N
AA
M
-
K
S
Q
IDAMS
H
VMFGGITH
A
PA
I
E
L
C
R
K
L
VAMT
P
QPL-EC
V
FLAD
SGS
V
A
V
E
V
A
M
K
M
A
L
QYWQAKGEA
-
R
QHF
L
T
F
R
N
G
YHG
D
T
--------
FG
A
MS
V
CDPDNS
M
HSLWK
G
YL
P
E
N
LFAPAPQSRMDGEWDERDMVGFARLMA-
-
AHRHEI
AA
V
I
I
EP
IV
QG
A
GG
MRMYH
PE
W
L
KR
I
R
K
M
CD
R
E
GILLI
A
DE
I
AT
G
FG
RTG
K
LFA
CEHAEIA
PD
I
L
C
L
G
K
A
L
T
GG
T
M
T
L
S
A
TL
T
T
R
EV
A
E
T
IS
N
G
E
AG
CFMH
G
P
T
FM
GNPLA
C
AAA
N
A
S
L
AILESGDWQ
Q
QVAAIEV
Q
L
R
E
Q
L
AP
A
R
D
A-EMVA
DVR
V
LG
fig|478007.5.peg.3409
Escherichia coli O157:H7 str. EC508 (1-344/410)
MTS
P
LP
V
Y
P
V
A
---
--S
AEG
CE
L
I
L
S
D
G
RR
L
VD
GMS
SW
WAAIH
G
Y
N
HP
Q
L
N
AA
M
-
K
S
Q
IDAMS
H
VMFGGITH
A
PA
I
E
L
C
R
K
L
VAMT
P
QPL-EC
V
FLAD
SGS
V
A
V
E
V
A
M
K
M
A
L
QYWQAKGEA
-
R
QHF
L
T
F
R
N
G
YHG
D
T
--------
FG
A
MS
V
CDPDNS
M
HSLWK
G
YL
P
E
N
LFAPAPQSRMDGEWDERDMVGFARLMA-
-
AHRHEI
AA
V
I
I
EP
IV
QG
A
GG
MRMYH
PE
W
L
KR
I
R
K
M
CD
R
E
GILLI
A
DE
I
AT
G
FG
RTG
K
LFA
CEHAEIA
PD
I
L
C
L
G
K
A
L
T
GG
T
M
T
L
S
A
TL
T
T
R
EV
A
E
T
IS
N
G
E
AG
CFMH
G
P
T
FM
GNPLA
C
AAA
N
A
S
L
AILESGDWQ
Q
QVAAIEV
Q
L
R
E
Q
L
AP
A
R
D
A-EMVA
DVR
V
LG
fig|386585.9.peg.966
Escherichia coli O157:H7 str. Sakai (1-344/410)
MTS
P
LP
V
Y
P
V
A
---
--S
AEG
CE
L
I
L
S
D
G
RR
L
VD
GMS
SW
WAAIH
G
Y
N
HP
Q
L
N
AA
M
-
K
S
Q
IDAMS
H
VMFGGITH
A
PA
I
E
L
C
R
K
L
VAMT
P
QPL-EC
V
FLAD
SGS
V
A
V
E
V
A
M
K
M
A
L
QYWQAKGEA
-
R
QHF
L
T
F
R
N
G
YHG
D
T
--------
FG
A
MS
V
CDPDNS
M
HSLWK
G
YL
P
E
N
LFAPAPQSRMDGEWDERDMVGFARLMA-
-
AHRHEI
AA
V
I
I
EP
IV
QG
A
GG
MRMYH
PE
W
L
KR
I
R
K
M
CD
R
E
GILLI
A
DE
I
AT
G
FG
RTG
K
LFA
CEHAEIA
PD
I
L
C
L
G
K
A
L
T
GG
T
M
T
L
S
A
TL
T
T
R
EV
A
E
T
IS
N
G
E
AG
CFMH
G
P
T
FM
GNPLA
C
AAA
N
A
S
L
AILESGDWQ
Q
QVAAIEV
Q
L
R
E
Q
L
AP
A
R
D
A-EMVA
DVR
V
LG
fig|544404.4.peg.876
Escherichia coli O157:H7 str. TW14359 (1-344/410)
MTS
P
LP
V
Y
P
V
A
---
--S
AEG
CE
L
I
L
S
D
G
RR
L
VD
GMS
SW
WAAIH
G
Y
N
HP
Q
L
N
AA
M
-
K
S
Q
IDAMS
H
VMFGGITH
A
PA
I
E
L
C
R
K
L
VAMT
P
QPL-EC
V
FLAD
SGS
V
A
V
E
V
A
M
K
M
A
L
QYWQAKGEA
-
R
QHF
L
T
F
R
N
G
YHG
D
T
--------
FG
A
MS
V
CDPDNS
M
HSLWK
G
YL
P
E
N
LFAPAPQSRMDGEWDERDMVGFARLMA-
-
AHRHEI
AA
V
I
I
EP
IV
QG
A
GG
MRMYH
PE
W
L
KR
I
R
K
M
CD
R
E
GILLI
A
DE
I
AT
G
FG
RTG
K
LFA
CEHAEIA
PD
I
L
C
L
G
K
A
L
T
GG
T
M
T
L
S
A
TL
T
T
R
EV
A
E
T
IS
N
G
E
AG
CFMH
G
P
T
FM
GNPLA
C
AAA
N
A
S
L
AILESGDWQ
Q
QVAAIEV
Q
L
R
E
Q
L
AP
A
R
D
A-EMVA
DVR
V
LG
fig|502346.5.peg.340
Escherichia coli O157:H7 str. TW14588 (1-344/410)
MTS
P
LP
V
Y
P
V
A
---
--S
AEG
CE
L
I
L
S
D
G
RR
L
VD
GMS
SW
WAAIH
G
Y
N
HP
Q
L
N
AA
M
-
K
S
Q
IDAMS
H
VMFGGITH
A
PA
I
E
L
C
R
K
L
VAMT
P
QPL-EC
V
FLAD
SGS
V
A
V
E
V
A
M
K
M
A
L
QYWQAKGEA
-
R
QHF
L
T
F
R
N
G
YHG
D
T
--------
FG
A
MS
V
CDPDNS
M
HSLWK
G
YL
P
E
N
LFAPAPQSRMDGEWDERDMVGFARLMA-
-
AHRHEI
AA
V
I
I
EP
IV
QG
A
GG
MRMYH
PE
W
L
KR
I
R
K
M
CD
R
E
GILLI
A
DE
I
AT
G
FG
RTG
K
LFA
CEHAEIA
PD
I
L
C
L
G
K
A
L
T
GG
T
M
T
L
S
A
TL
T
T
R
EV
A
E
T
IS
N
G
E
AG
CFMH
G
P
T
FM
GNPLA
C
AAA
N
A
S
L
AILESGDWQ
Q
QVAAIEV
Q
L
R
E
Q
L
AP
A
R
D
A-EMVA
DVR
V
LG
fig|701177.3.peg.984
Escherichia coli O55:H7 str. CB9615 (1-344/410)
MTS
P
LP
V
Y
P
V
A
---
--S
AEG
CE
L
I
L
S
D
G
RR
L
VD
GMS
SW
WAAIH
G
Y
N
HP
Q
L
N
AA
M
-
K
S
Q
IDAMS
H
VMFGGITH
A
PA
I
E
L
C
R
K
L
VAMT
P
QPL-EC
V
FLAD
SGS
V
A
V
E
V
A
M
K
M
A
L
QYWQAKGEA
-
R
QHF
L
T
F
R
N
G
YHG
D
T
--------
FG
A
MS
V
CDPDNS
M
HSLWK
G
YL
P
E
N
LFAPAPQSRMDGEWDERDMVGFARLMA-
-
AHRHEI
AA
V
I
I
EP
IV
QG
A
GG
MRMYH
PE
W
L
KR
I
R
K
M
CD
R
E
GILLI
A
DE
I
AT
G
FG
RTG
K
LFA
CEHAEIA
PD
I
L
C
L
G
K
A
L
T
GG
T
M
T
L
S
A
TL
T
T
R
EV
A
E
T
IS
N
G
E
AG
CFMH
G
P
T
FM
GNPLA
C
AAA
N
A
S
L
AILESGDWQ
Q
QVAAIEV
Q
L
R
E
Q
L
AP
A
R
D
A-EMVA
DVR
V
LG
fig|83334.1.peg.922
Escherichia coli O157:H7 (20-363/429)
MTS
P
LP
V
Y
P
V
A
---
--S
AEG
CE
L
I
L
S
D
G
RR
L
VD
GMS
SW
WAAIH
G
Y
N
HP
Q
L
N
AA
M
-
K
S
Q
IDAMS
H
VMFGGITH
A
PA
I
E
L
C
R
K
L
VAMT
P
QPL-EC
V
FLAD
SGS
V
A
V
E
V
A
M
K
M
A
L
QYWQAKGEA
-
R
QHF
L
T
F
R
N
G
YHG
D
T
--------
FG
A
MS
V
CDPDNS
M
HSLWK
G
YL
P
E
N
LFAPAPQSRMDGEWDERDMVGFARLMA-
-
AHRHEI
AA
V
I
I
EP
IV
QG
A
GG
MRMYH
PE
W
L
KR
I
R
K
M
CD
R
E
GILLI
A
DE
I
AT
G
FG
RTG
K
LFA
CEHAEIA
PD
I
L
C
L
G
K
A
L
T
GG
T
M
T
L
S
A
TL
T
T
R
EV
A
E
T
IS
N
G
E
AG
CFMH
G
P
T
FM
GNPLA
C
AAA
N
A
S
L
AILESGDWQ
Q
QVAAIEV
Q
L
R
E
Q
L
AP
A
R
D
A-EMVA
DVR
V
LG
fig|550676.3.peg.234
Escherichia coli B185 (1-344/410)
MTS
P
LP
V
Y
P
V
A
---
--S
AEG
CE
L
I
L
S
D
G
RR
L
VD
GMS
SW
WAAIH
G
Y
N
HP
Q
L
N
AA
M
-
K
T
Q
IDAMS
H
VMFGGITH
A
PA
I
E
L
C
R
K
L
VAMT
P
QPL-EC
V
FLAD
SGS
V
A
V
E
V
A
M
K
M
A
L
QYWQAKGEA
-
R
QRF
L
T
F
R
N
G
YHG
D
T
--------
FG
A
MS
V
CDPDNS
M
HSLWK
G
YL
P
E
N
LFAPAPQSRMDGEWDERDMVGFARLMA-
-
AHRHEI
AA
V
I
I
EP
IV
QG
A
GG
MRMYH
PE
W
L
KR
I
R
K
M
CD
R
E
GILLI
A
DE
I
AT
G
FG
RTG
K
LFA
CEYAEIA
PD
I
L
C
L
G
K
A
L
T
GG
T
M
T
L
S
A
TL
T
T
R
EV
A
E
T
IS
N
G
E
AG
CFMH
G
P
T
FM
GNPLA
C
AAA
N
A
S
L
AILESGDWQ
Q
QVAAIEV
Q
L
R
E
Q
L
AP
A
R
D
A-EMVA
DVR
V
LG
fig|340184.6.peg.3683
Escherichia coli B7A (1-344/410)
MTS
P
LP
V
Y
P
V
A
---
--S
AEG
CE
L
I
L
S
D
G
RR
L
VD
GMS
SW
WAAIH
G
Y
N
HP
Q
L
N
AA
M
-
K
S
Q
IDAMS
H
VMFGGITH
A
PA
I
E
L
C
C
K
L
VAMT
P
QPL-EC
V
FLAD
SGS
V
A
V
E
V
A
M
K
M
A
L
QYWQAKGEA
-
R
QRF
L
T
F
R
N
G
YHG
D
T
--------
FG
A
MS
V
CDPDNS
M
HSLWK
G
YL
P
E
N
LFAPAPQSRMDGEWDERDMVGFARLMA-
-
AHRHEI
AA
V
I
I
EP
IV
QG
A
GG
MRMYH
PE
W
L
KR
I
R
K
M
CD
R
E
GILLI
A
DE
I
AT
G
FG
RTG
K
LFA
CEHAEIA
PD
I
L
C
L
G
K
A
L
T
GG
T
M
T
L
S
A
TL
T
T
R
EV
A
E
T
IS
N
G
E
AG
CFMH
G
P
T
FM
GNPLA
C
AAA
N
A
S
L
AILESGDWQ
Q
QVAAIEV
Q
L
R
E
Q
L
AP
A
R
D
A-EMVA
DVR
V
LG
fig|679204.3.peg.4984
Escherichia coli MS 145-7 (1-344/410)
MTS
P
LP
V
Y
P
V
A
---
--S
AEG
CE
L
I
L
S
D
G
RR
L
VD
GMS
SW
WAAIH
G
Y
N
HP
Q
L
N
AA
M
-
K
S
Q
IDAMS
H
VMFGGITH
A
PA
I
E
L
C
C
K
L
VAMT
P
QPL-EC
V
FLAD
SGS
V
A
V
E
V
A
M
K
M
A
L
QYWQAKGEA
-
R
QRF
L
T
F
R
N
G
YHG
D
T
--------
FG
A
MS
V
CDPDNS
M
HSLWK
G
YL
P
E
N
LFAPAPQSRMDGEWDERDMVGFARLMA-
-
AHRHEI
AA
V
I
I
EP
IV
QG
A
GG
MRMYH
PE
W
L
KR
I
R
K
M
CD
R
E
GILLI
A
DE
I
AT
G
FG
RTG
K
LFA
CEHAEIA
PD
I
L
C
L
G
K
A
L
T
GG
T
M
T
L
S
A
TL
T
T
R
EV
A
E
T
IS
N
G
E
AG
CFMH
G
P
T
FM
GNPLA
C
AAA
N
A
S
L
AILESGDWQ
Q
QVAAIEV
Q
L
R
E
Q
L
AP
A
R
D
A-EMVA
DVR
V
LG
fig|340184.3.peg.3520
Escherichia coli B7A (57-400/466)
MTS
P
LP
V
Y
P
V
A
---
--S
AEG
CE
L
I
L
S
D
G
RR
L
VD
GMS
SW
WAAIH
G
Y
N
HP
Q
L
N
AA
M
-
K
S
Q
IDAMS
H
VMFGGITH
A
PA
I
E
L
C
C
K
L
VAMT
P
QPL-EC
V
FLAD
SGS
V
A
V
E
V
A
M
K
M
A
L
QYWQAKGEA
-
R
QRF
L
T
F
R
N
G
YHG
D
T
--------
FG
A
MS
V
CDPDNS
M
HSLWK
G
YL
P
E
N
LFAPAPQSRMDGEWDERDMVGFARLMA-
-
AHRHEI
AA
V
I
I
EP
IV
QG
A
GG
MRMYH
PE
W
L
KR
I
R
K
M
CD
R
E
GILLI
A
DE
I
AT
G
FG
RTG
K
LFA
CEHAEIA
PD
I
L
C
L
G
K
A
L
T
GG
T
M
T
L
S
A
TL
T
T
R
EV
A
E
T
IS
N
G
E
AG
CFMH
G
P
T
FM
GNPLA
C
AAA
N
A
S
L
AILESGDWQ
Q
QVAAIEV
Q
L
R
E
Q
L
AP
A
R
D
A-EMVA
DVR
V
LG
fig|670888.3.peg.1333
Escherichia coli 1827-70 (1-344/410)
MTS
P
LP
V
Y
P
V
A
---
--S
AEG
CE
L
I
L
S
D
G
RR
L
VD
GMS
SW
WAAIH
G
Y
N
HP
Q
L
N
AA
M
-
K
S
Q
IDAMS
H
VMFGGITH
A
PA
I
E
L
C
R
K
L
VAMT
P
QPL-EC
V
FLAD
SGS
V
A
V
E
V
A
M
K
M
A
L
QYWQAKGEA
-
R
QRF
L
T
F
R
N
G
YHG
D
T
--------
FG
A
MS
V
CDPDNS
M
HSLWK
G
YL
P
E
N
LFAPAPQSRMDGEWDERDMVGFARLMA-
-
AHRHEI
AA
V
I
I
EP
IV
QG
A
GG
MRMYH
PE
W
L
KR
I
R
K
I
CD
R
E
GILLI
A
DE
I
AT
G
FG
RTG
K
LFA
CEHAEIA
PD
I
L
C
L
G
K
A
L
T
GG
T
M
T
L
S
A
TL
T
T
R
EV
A
E
T
IS
N
G
E
AG
CFMH
G
P
T
FM
GNPLA
C
AAA
N
A
S
L
AILESGDWQ
Q
QVADIEV
Q
L
R
E
Q
L
AP
A
R
D
A-EMVA
DVR
V
LG
fig|344610.7.peg.915
Escherichia coli 53638 (1-344/410)
MTS
P
LP
V
Y
P
V
A
---
--S
AEG
CE
L
I
L
S
D
G
RR
L
VD
GMS
SW
WAAIH
G
Y
N
HP
Q
L
N
AA
M
-
K
S
Q
IDAMS
H
VMFGGITH
A
PA
I
E
L
C
R
K
L
VAMT
P
QPL-EC
V
FLAD
SGS
V
A
V
E
V
A
M
K
M
A
L
QYWQAKGEA
-
R
QRF
L
T
F
R
N
G
YHG
D
T
--------
FG
A
MS
V
CDPDNS
M
HSLWK
G
YL
P
E
N
LFAPAPQSRMDGEWDERDMVGFARLMA-
-
AHRHEI
AA
V
I
I
EP
IV
QG
A
GG
MRMYH
PE
W
L
KR
I
R
K
I
CD
R
E
GILLI
A
DE
I
AT
G
FG
RTG
K
LFA
CEHAEIA
PD
I
L
C
L
G
K
A
L
T
GG
T
M
T
L
S
A
TL
T
T
R
EV
A
E
T
IS
N
G
E
AG
CFMH
G
P
T
FM
GNPLA
C
AAA
N
A
S
L
AILESGDWQ
Q
QVADIEV
Q
L
R
E
Q
L
AP
A
R
D
A-EMVA
DVR
V
LG
fig|481805.6.peg.3069
Escherichia coli ATCC 8739 (1-344/410)
MTS
P
LP
V
Y
P
V
A
---
--S
AEG
CE
L
I
L
S
D
G
RR
L
VD
GMS
SW
WAAIH
G
Y
N
HP
Q
L
N
AA
M
-
K
S
Q
IDAMS
H
VMFGGITH
A
PA
I
E
L
C
R
K
L
VAMT
P
QPL-EC
V
FLAD
SGS
V
A
V
E
V
A
M
K
M
A
L
QYWQAKGEA
-
R
QRF
L
T
F
R
N
G
YHG
D
T
--------
FG
A
MS
V
CDPDNS
M
HSLWK
G
YL
P
E
N
LFAPAPQSRMDGEWDERDMVGFARLMA-
-
AHRHEI
AA
V
I
I
EP
IV
QG
A
GG
MRMYH
PE
W
L
KR
I
R
K
I
CD
R
E
GILLI
A
DE
I
AT
G
FG
RTG
K
LFA
CEHAEIA
PD
I
L
C
L
G
K
A
L
T
GG
T
M
T
L
S
A
TL
T
T
R
EV
A
E
T
IS
N
G
E
AG
CFMH
G
P
T
FM
GNPLA
C
AAA
N
A
S
L
AILESGDWQ
Q
QVADIEV
Q
L
R
E
Q
L
AP
A
R
D
A-EMVA
DVR
V
LG
fig|331112.6.peg.798
Escherichia coli HS (1-344/410)
MTS
P
LP
V
Y
P
V
A
---
--S
AEG
CE
L
I
L
S
D
G
RR
L
VD
GMS
SW
WAAIH
G
Y
N
HP
Q
L
N
AA
M
-
K
S
Q
IDAMS
H
VMFGGITH
A
PA
I
E
L
C
R
K
L
VAMT
P
QPL-EC
V
FLAD
SGS
V
A
V
E
V
A
M
K
M
A
L
QYWQAKGEA
-
R
QRF
L
T
F
R
N
G
YHG
D
T
--------
FG
A
MS
V
CDPDNS
M
HSLWK
G
YL
P
E
N
LFAPAPQSRMDGEWDERDMVGFARLMA-
-
AHRHEI
AA
V
I
I
EP
IV
QG
A
GG
MRMYH
PE
W
L
KR
I
R
K
I
CD
R
E
GILLI
A
DE
I
AT
G
FG
RTG
K
LFA
CEHAEIA
PD
I
L
C
L
G
K
A
L
T
GG
T
M
T
L
S
A
TL
T
T
R
EV
A
E
T
IS
N
G
E
AG
CFMH
G
P
T
FM
GNPLA
C
AAA
N
A
S
L
AILESGDWQ
Q
QVADIEV
Q
L
R
E
Q
L
AP
A
R
D
A-EMVA
DVR
V
LG
fig|358709.5.peg.4504
Escherichia coli 101-1 (1-344/410)
MTS
P
LP
V
Y
P
V
V
---
--S
AEG
CE
L
I
L
S
D
G
RR
L
VD
GMS
SW
WAAIH
G
Y
N
HP
Q
L
N
AA
M
-
K
S
Q
IDAMS
H
VMFGGITH
A
PA
I
E
L
C
R
K
L
VAMT
P
QPL-EC
V
FLAD
SGS
V
A
V
E
V
A
M
K
M
A
L
QYWQAKGEA
-
R
QRF
L
T
F
R
N
G
YHG
D
T
--------
FG
A
MS
V
CDPDNS
M
HSLWK
G
YL
P
E
N
LFAPAPQSRMDGEWDERDMVGFARLMA-
-
AHRHEI
AA
V
I
I
EP
IV
QG
A
GG
MRMYH
PE
W
L
KR
I
R
K
M
CD
R
E
GILLI
A
DE
I
AT
G
FG
RTG
K
LFA
CEYAEIA
PD
I
L
C
L
G
K
A
L
T
GG
T
M
T
L
S
A
TL
T
T
R
EV
A
E
T
IS
N
G
E
AG
CFMH
G
P
T
FM
GNPLA
C
AAA
N
A
S
L
AILESGDWQ
Q
QVAAIEV
Q
L
R
E
Q
L
AP
A
R
D
A-EMVA
DVR
V
LG
fig|413997.3.peg.783
Escherichia coli B str. REL606 (1-344/410)
MTS
P
LP
V
Y
P
V
V
---
--S
AEG
CE
L
I
L
S
D
G
RR
L
VD
GMS
SW
WAAIH
G
Y
N
HP
Q
L
N
AA
M
-
K
S
Q
IDAMS
H
VMFGGITH
A
PA
I
E
L
C
R
K
L
VAMT
P
QPL-EC
V
FLAD
SGS
V
A
V
E
V
A
M
K
M
A
L
QYWQAKGEA
-
R
QRF
L
T
F
R
N
G
YHG
D
T
--------
FG
A
MS
V
CDPDNS
M
HSLWK
G
YL
P
E
N
LFAPAPQSRMDGEWDERDMVGFARLMA-
-
AHRHEI
AA
V
I
I
EP
IV
QG
A
GG
MRMYH
PE
W
L
KR
I
R
K
M
CD
R
E
GILLI
A
DE
I
AT
G
FG
RTG
K
LFA
CEYAEIA
PD
I
L
C
L
G
K
A
L
T
GG
T
M
T
L
S
A
TL
T
T
R
EV
A
E
T
IS
N
G
E
AG
CFMH
G
P
T
FM
GNPLA
C
AAA
N
A
S
L
AILESGDWQ
Q
QVAAIEV
Q
L
R
E
Q
L
AP
A
R
D
A-EMVA
DVR
V
LG
fig|511693.5.peg.811
Escherichia coli BL21 (1-344/410)
MTS
P
LP
V
Y
P
V
V
---
--S
AEG
CE
L
I
L
S
D
G
RR
L
VD
GMS
SW
WAAIH
G
Y
N
HP
Q
L
N
AA
M
-
K
S
Q
IDAMS
H
VMFGGITH
A
PA
I
E
L
C
R
K
L
VAMT
P
QPL-EC
V
FLAD
SGS
V
A
V
E
V
A
M
K
M
A
L
QYWQAKGEA
-
R
QRF
L
T
F
R
N
G
YHG
D
T
--------
FG
A
MS
V
CDPDNS
M
HSLWK
G
YL
P
E
N
LFAPAPQSRMDGEWDERDMVGFARLMA-
-
AHRHEI
AA
V
I
I
EP
IV
QG
A
GG
MRMYH
PE
W
L
KR
I
R
K
M
CD
R
E
GILLI
A
DE
I
AT
G
FG
RTG
K
LFA
CEYAEIA
PD
I
L
C
L
G
K
A
L
T
GG
T
M
T
L
S
A
TL
T
T
R
EV
A
E
T
IS
N
G
E
AG
CFMH
G
P
T
FM
GNPLA
C
AAA
N
A
S
L
AILESGDWQ
Q
QVAAIEV
Q
L
R
E
Q
L
AP
A
R
D
A-EMVA
DVR
V
LG
fig|469008.4.peg.2950
Escherichia coli BL21(DE3) (1-344/410)
MTS
P
LP
V
Y
P
V
V
---
--S
AEG
CE
L
I
L
S
D
G
RR
L
VD
GMS
SW
WAAIH
G
Y
N
HP
Q
L
N
AA
M
-
K
S
Q
IDAMS
H
VMFGGITH
A
PA
I
E
L
C
R
K
L
VAMT
P
QPL-EC
V
FLAD
SGS
V
A
V
E
V
A
M
K
M
A
L
QYWQAKGEA
-
R
QRF
L
T
F
R
N
G
YHG
D
T
--------
FG
A
MS
V
CDPDNS
M
HSLWK
G
YL
P
E
N
LFAPAPQSRMDGEWDERDMVGFARLMA-
-
AHRHEI
AA
V
I
I
EP
IV
QG
A
GG
MRMYH
PE
W
L
KR
I
R
K
M
CD
R
E
GILLI
A
DE
I
AT
G
FG
RTG
K
LFA
CEYAEIA
PD
I
L
C
L
G
K
A
L
T
GG
T
M
T
L
S
A
TL
T
T
R
EV
A
E
T
IS
N
G
E
AG
CFMH
G
P
T
FM
GNPLA
C
AAA
N
A
S
L
AILESGDWQ
Q
QVAAIEV
Q
L
R
E
Q
L
AP
A
R
D
A-EMVA
DVR
V
LG
fig|749547.3.peg.1678
Escherichia coli MS 187-1 (1-344/410)
MTS
P
LP
V
Y
P
V
V
---
--S
AEG
CE
L
I
L
S
D
G
RR
L
VD
GMS
SW
WAAIH
G
Y
N
HP
Q
L
N
AA
M
-
K
S
Q
IDAMS
H
VMFGGITH
A
PA
I
E
L
C
R
K
L
VAMT
P
QPL-EC
V
FLAD
SGS
V
A
V
E
V
A
M
K
M
A
L
QYWQAKGEA
-
R
QRF
L
T
F
R
N
G
YHG
D
T
--------
FG
A
MS
V
CDPDNS
M
HSLWK
G
YL
P
E
N
LFAPAPQSRMDGEWDERDMVGFARLMA-
-
AHRHEI
AA
V
I
I
EP
IV
QG
A
GG
MRMYH
PE
W
L
KR
I
R
K
M
CD
R
E
GILLI
A
DE
I
AT
G
FG
RTG
K
LFA
CEYAEIA
PD
I
L
C
L
G
K
A
L
T
GG
T
M
T
L
S
A
TL
T
T
R
EV
A
E
T
IS
N
G
E
AG
CFMH
G
P
T
FM
GNPLA
C
AAA
N
A
S
L
AILESGDWQ
Q
QVAAIEV
Q
L
R
E
Q
L
AP
A
R
D
A-EMVA
DVR
V
LG
fig|478008.5.peg.2244
Escherichia coli O157:H7 str. EC869 (1-344/415)
MTS
P
LP
V
Y
P
V
A
---
--S
AEG
CE
L
I
L
S
D
G
RR
L
VD
GMS
SW
WAAIH
G
Y
N
HP
Q
L
N
AA
M
-
K
S
Q
INAMS
H
VMFGGITH
A
PA
I
E
L
C
R
K
L
VAMT
P
QPL-EC
V
FLAD
SGS
V
A
V
E
V
A
M
K
M
A
L
QYWQAKGEA
-
R
QHF
L
T
F
R
N
G
YHG
D
T
--------
FG
A
MS
V
CDPDNS
M
HSLWK
G
YL
P
E
N
LFAPAPQSRMDGEWDERDMVGFARLMA-
-
AHRHEI
AA
V
I
I
EP
IV
QG
A
GG
MRMYH
PE
W
L
KR
I
R
K
M
CD
R
E
GILLI
A
DE
I
AT
G
FG
RTG
K
LFA
CEHAEIA
PD
I
L
C
L
G
K
A
L
T
GG
T
M
T
L
S
A
TL
T
T
R
EV
A
E
T
IS
N
G
E
AG
CFMH
G
P
T
FM
GNPLA
C
AAA
N
A
S
L
AILESGDWQ
Q
QVAAIEV
Q
L
R
E
Q
L
AP
A
R
D
A-EMVA
DVR
V
LG
fig|637388.3.peg.2544
Escherichia coli O157:H7 str. FRIK2000 (1-344/415)
MTS
P
LP
V
Y
P
V
A
---
--S
AEG
CE
L
I
L
S
D
G
RR
L
VD
GMS
SW
WAAIH
G
Y
N
HP
Q
L
N
AA
M
-
K
S
Q
INAMS
H
VMFGGITH
A
PA
I
E
L
C
R
K
L
VAMT
P
QPL-EC
V
FLAD
SGS
V
A
V
E
V
A
M
K
M
A
L
QYWQAKGEA
-
R
QHF
L
T
F
R
N
G
YHG
D
T
--------
FG
A
MS
V
CDPDNS
M
HSLWK
G
YL
P
E
N
LFAPAPQSRMDGEWDERDMVGFARLMA-
-
AHRHEI
AA
V
I
I
EP
IV
QG
A
GG
MRMYH
PE
W
L
KR
I
R
K
M
CD
R
E
GILLI
A
DE
I
AT
G
FG
RTG
K
LFA
CEHAEIA
PD
I
L
C
L
G
K
A
L
T
GG
T
M
T
L
S
A
TL
T
T
R
EV
A
E
T
IS
N
G
E
AG
CFMH
G
P
T
FM
GNPLA
C
AAA
N
A
S
L
AILESGDWQ
Q
QVAAIEV
Q
L
R
E
Q
L
AP
A
R
D
A-EMVA
DVR
V
LG
fig|570506.3.peg.4485
Escherichia coli O157:H7 str. FRIK966 (1-344/415)
MTS
P
LP
V
Y
P
V
A
---
--S
AEG
CE
L
I
L
S
D
G
RR
L
VD
GMS
SW
WAAIH
G
Y
N
HP
Q
L
N
AA
M
-
K
S
Q
INAMS
H
VMFGGITH
A
PA
I
E
L
C
R
K
L
VAMT
P
QPL-EC
V
FLAD
SGS
V
A
V
E
V
A
M
K
M
A
L
QYWQAKGEA
-
R
QHF
L
T
F
R
N
G
YHG
D
T
--------
FG
A
MS
V
CDPDNS
M
HSLWK
G
YL
P
E
N
LFAPAPQSRMDGEWDERDMVGFARLMA-
-
AHRHEI
AA
V
I
I
EP
IV
QG
A
GG
MRMYH
PE
W
L
KR
I
R
K
M
CD
R
E
GILLI
A
DE
I
AT
G
FG
RTG
K
LFA
CEHAEIA
PD
I
L
C
L
G
K
A
L
T
GG
T
M
T
L
S
A
TL
T
T
R
EV
A
E
T
IS
N
G
E
AG
CFMH
G
P
T
FM
GNPLA
C
AAA
N
A
S
L
AILESGDWQ
Q
QVAAIEV
Q
L
R
E
Q
L
AP
A
R
D
A-EMVA
DVR
V
LG
fig|344610.3.peg.4650
Escherichia coli 53638 (57-400/466)
MTS
P
LP
V
Y
P
V
A
---
--S
AEG
CE
L
I
L
S
D
G
RR
L
VD
GMS
SW
WAAIH
G
Y
N
HP
Q
L
N
AA
M
-
K
S
Q
IDAMS
H
VMFGGITH
A
PA
I
E
L
C
R
K
L
VAMT
P
QPL-EC
V
FLAD
SGS
V
A
V
E
V
A
M
K
M
A
L
QYWQAKGEA
-
R
QRF
L
T
F
R
N
G
YHG
D
T
--------
FG
A
MS
V
CDPDNS
M
HSLWK
G
YL
P
E
N
LFAPAPQSRMDGEWDERDMVGFARLMA-
-
AHRHEI
AA
V
I
I
EP
IV
QG
A
GG
MRMYH
PE
W
L
KR
I
R
K
I
CD
R
E
GILLI
A
DE
I
AT
G
FG
RTG
K
LFA
CEHAEIA
PD
I
L
C
L
G
K
A
L
T
GG
T
M
T
L
S
A
TL
T
T
R
EV
A
E
T
IS
N
G
E
AG
CFMH
G
P
T
FM
GNPLA
C
AAA
N
A
S
L
AILESGDWQ
Q
QVADIEV
Q
L
R
E
Q
L
AP
A
R
D
A-EMVA
DVR
V
LG
fig|481805.3.peg.3084
Escherichia coli ATCC 8739 (57-400/466)
MTS
P
LP
V
Y
P
V
A
---
--S
AEG
CE
L
I
L
S
D
G
RR
L
VD
GMS
SW
WAAIH
G
Y
N
HP
Q
L
N
AA
M
-
K
S
Q
IDAMS
H
VMFGGITH
A
PA
I
E
L
C
R
K
L
VAMT
P
QPL-EC
V
FLAD
SGS
V
A
V
E
V
A
M
K
M
A
L
QYWQAKGEA
-
R
QRF
L
T
F
R
N
G
YHG
D
T
--------
FG
A
MS
V
CDPDNS
M
HSLWK
G
YL
P
E
N
LFAPAPQSRMDGEWDERDMVGFARLMA-
-
AHRHEI
AA
V
I
I
EP
IV
QG
A
GG
MRMYH
PE
W
L
KR
I
R
K
I
CD
R
E
GILLI
A
DE
I
AT
G
FG
RTG
K
LFA
CEHAEIA
PD
I
L
C
L
G
K
A
L
T
GG
T
M
T
L
S
A
TL
T
T
R
EV
A
E
T
IS
N
G
E
AG
CFMH
G
P
T
FM
GNPLA
C
AAA
N
A
S
L
AILESGDWQ
Q
QVADIEV
Q
L
R
E
Q
L
AP
A
R
D
A-EMVA
DVR
V
LG
fig|331112.3.peg.764
Escherichia coli HS (57-400/466)
MTS
P
LP
V
Y
P
V
A
---
--S
AEG
CE
L
I
L
S
D
G
RR
L
VD
GMS
SW
WAAIH
G
Y
N
HP
Q
L
N
AA
M
-
K
S
Q
IDAMS
H
VMFGGITH
A
PA
I
E
L
C
R
K
L
VAMT
P
QPL-EC
V
FLAD
SGS
V
A
V
E
V
A
M
K
M
A
L
QYWQAKGEA
-
R
QRF
L
T
F
R
N
G
YHG
D
T
--------
FG
A
MS
V
CDPDNS
M
HSLWK
G
YL
P
E
N
LFAPAPQSRMDGEWDERDMVGFARLMA-
-
AHRHEI
AA
V
I
I
EP
IV
QG
A
GG
MRMYH
PE
W
L
KR
I
R
K
I
CD
R
E
GILLI
A
DE
I
AT
G
FG
RTG
K
LFA
CEHAEIA
PD
I
L
C
L
G
K
A
L
T
GG
T
M
T
L
S
A
TL
T
T
R
EV
A
E
T
IS
N
G
E
AG
CFMH
G
P
T
FM
GNPLA
C
AAA
N
A
S
L
AILESGDWQ
Q
QVADIEV
Q
L
R
E
Q
L
AP
A
R
D
A-EMVA
DVR
V
LG
fig|155864.8.peg.871
Escherichia coli O157:H7 EDL933 (1-344/410)
MTS
P
LP
V
Y
P
V
A
---
--S
AEG
CE
L
I
L
S
D
G
RR
L
VD
GMS
SW
WAAIH
G
Y
N
HP
Q
L
N
AA
M
-
K
S
Q
IDAMS
H
VMFGGITH
A
PA
I
E
L
C
R
K
L
VAMT
P
QPL-EC
V
FLAD
SGS
V
A
V
E
V
A
M
K
M
A
L
QYWQAKGEA
-
R
QHF
L
T
F
R
N
G
YHG
D
T
--------
FG
A
MS
V
CDPDNS
M
HSLWK
G
YL
P
E
N
LFAPAPQSRMDGEWDERDMVGFARLMA-
-
AHRHEI
AA
V
I
I
EP
IV
QG
A
GG
MRMYH
PE
W
L
KR
I
R
K
M
CD
R
E
GILLI
A
DE
I
AT
G
FG
RTG
K
LFA
CEHAEIA
PD
I
L
C
L
G
K
A
L
T
GG
T
M
T
L
S
A
TL
T
T
R
EV
A
E
T
IS
N
G
E
AG
CFMH
G
P
T
FM
GNPLA
C
AAA
N
A
S
L
AILESGDWQ
Q
QVAAIEV
X
L
R
E
Q
L
AP
A
R
D
A-EMVA
DVR
V
LG
fig|155864.1.peg.845
Escherichia coli O157:H7 EDL933 (20-363/429)
MTS
P
LP
V
Y
P
V
A
---
--S
AEG
CE
L
I
L
S
D
G
RR
L
VD
GMS
SW
WAAIH
G
Y
N
HP
Q
L
N
AA
M
-
K
S
Q
IDAMS
H
VMFGGITH
A
PA
I
E
L
C
R
K
L
VAMT
P
QPL-EC
V
FLAD
SGS
V
A
V
E
V
A
M
K
M
A
L
QYWQAKGEA
-
R
QHF
L
T
F
R
N
G
YHG
D
T
--------
FG
A
MS
V
CDPDNS
M
HSLWK
G
YL
P
E
N
LFAPAPQSRMDGEWDERDMVGFARLMA-
-
AHRHEI
AA
V
I
I
EP
IV
QG
A
GG
MRMYH
PE
W
L
KR
I
R
K
M
CD
R
E
GILLI
A
DE
I
AT
G
FG
RTG
K
LFA
CEHAEIA
PD
I
L
C
L
G
K
A
L
T
GG
T
M
T
L
S
A
TL
T
T
R
EV
A
E
T
IS
N
G
E
AG
CFMH
G
P
T
FM
GNPLA
C
AAA
N
A
S
L
AILESGDWQ
Q
QVAAIEV
X
L
R
E
Q
L
AP
A
R
D
A-EMVA
DVR
V
LG
fig|566546.3.peg.3793
Escherichia coli W (1-344/410)
MTS
P
LP
V
Y
P
V
A
---
--S
AEG
CE
L
I
L
S
D
G
RR
L
VD
GMS
SW
WAAIH
G
Y
N
HP
Q
L
N
AA
M
-
K
T
Q
IDAMS
H
VMFGGITH
A
PA
I
E
L
C
R
K
L
VAMT
P
QPL-EC
V
FLAD
SGS
V
A
V
E
V
A
M
K
M
A
L
QYWQAKGEA
-
R
QRF
L
T
F
R
N
G
YHG
D
T
--------
FG
A
MS
V
CDPDNS
M
HSLWK
G
YL
P
E
N
LFAPAPQSRMDGEWDERDMVGFARLMA-
-
AHRHEI
AA
V
I
I
EP
IV
QG
A
GG
MRIYH
PE
W
L
KR
I
R
K
M
CD
R
E
GILLI
A
DE
I
AT
G
FG
RTG
K
LFA
CEHAGIA
PD
I
L
C
L
G
K
A
L
T
GG
T
M
T
L
S
A
TL
T
T
R
EV
A
E
T
IS
N
G
E
AG
CFMH
G
P
T
FM
GNPLA
C
AAA
N
A
S
L
AILESGDWQ
Q
QVAAIEV
Q
L
R
E
Q
L
AP
A
R
D
A-EMVA
DVR
V
LG
fig|566546.4.peg.823
Escherichia coli W (1-344/410)
MTS
P
LP
V
Y
P
V
A
---
--S
AEG
CE
L
I
L
S
D
G
RR
L
VD
GMS
SW
WAAIH
G
Y
N
HP
Q
L
N
AA
M
-
K
T
Q
IDAMS
H
VMFGGITH
A
PA
I
E
L
C
R
K
L
VAMT
P
QPL-EC
V
FLAD
SGS
V
A
V
E
V
A
M
K
M
A
L
QYWQAKGEA
-
R
QRF
L
T
F
R
N
G
YHG
D
T
--------
FG
A
MS
V
CDPDNS
M
HSLWK
G
YL
P
E
N
LFAPAPQSRMDGEWDERDMVGFARLMA-
-
AHRHEI
AA
V
I
I
EP
IV
QG
A
GG
MRIYH
PE
W
L
KR
I
R
K
M
CD
R
E
GILLI
A
DE
I
AT
G
FG
RTG
K
LFA
CEHAGIA
PD
I
L
C
L
G
K
A
L
T
GG
T
M
T
L
S
A
TL
T
T
R
EV
A
E
T
IS
N
G
E
AG
CFMH
G
P
T
FM
GNPLA
C
AAA
N
A
S
L
AILESGDWQ
Q
QVAAIEV
Q
L
R
E
Q
L
AP
A
R
D
A-EMVA
DVR
V
LG
fig|595495.4.peg.3251
Escherichia coli KO11 (1-344/431)
MTS
P
LP
V
Y
P
V
A
---
--S
AEG
CE
L
I
L
S
D
G
RR
L
VD
GMS
SW
WAAIH
G
Y
N
HP
Q
L
N
AA
M
-
K
T
Q
IDAMS
H
VMFGGITH
A
PA
I
E
L
C
R
K
L
VAMT
P
QPL-EC
V
FLAD
SGS
V
A
V
E
V
A
M
K
M
A
L
QYWQAKGEA
-
R
QRF
L
T
F
R
N
G
YHG
D
T
--------
FG
A
MS
V
CDPDNS
M
HSLWK
G
YL
P
E
N
LFAPAPQSRMDGEWDERDMVGFARLMA-
-
AHRHEI
AA
V
I
I
EP
IV
QG
A
GG
MRIYH
PE
W
L
KR
I
R
K
M
CD
R
E
GILLI
A
DE
I
AT
G
FG
RTG
K
LFA
CEHAGIA
PD
I
L
C
L
G
K
A
L
T
GG
T
M
T
L
S
A
TL
T
T
R
EV
A
E
T
IS
N
G
E
AG
CFMH
G
P
T
FM
GNPLA
C
AAA
N
A
S
L
AILESGDWQ
Q
QVAAIEV
Q
L
R
E
Q
L
AP
A
R
D
A-EMVA
DVR
V
LG
fig|595496.3.peg.695
Escherichia coli BW2952 (1-344/410)
MTS
P
LP
V
Y
P
V
V
---
--S
AEG
CE
L
I
L
S
D
G
RR
L
VD
GMS
SW
WAAIH
G
Y
N
HP
Q
L
N
AA
M
-
K
S
Q
IDAMS
H
VMFGGITH
A
PA
I
E
L
C
R
K
L
VAMT
P
QPL-EC
V
FLAD
SGS
V
A
V
E
V
A
M
K
M
A
L
QYWQAKGEA
-
R
QRF
L
T
F
R
N
G
YHG
D
T
--------
FG
A
MS
V
CDPDNS
M
HSLWK
G
YL
P
E
N
LFAPAPQSRMDGEWDERDMVGFARLMA-
-
AHRHEI
AA
V
I
I
EP
IV
QG
A
GG
MRMYH
PE
W
L
KR
I
R
K
I
CD
R
E
GILLI
A
DE
I
AT
G
FG
RTG
K
LFA
CEHAEIA
PD
I
L
C
L
G
K
A
L
T
GG
T
M
T
L
S
A
TL
T
T
R
EV
A
E
T
IS
N
G
E
AG
CFMH
G
P
T
FM
GNPLA
C
AAA
N
A
S
L
AILESGDWQ
Q
QVADIEV
Q
L
R
E
Q
L
AP
A
R
D
A-EMVA
DVR
V
LG
fig|536056.3.peg.3027
Escherichia coli DH1 (1-344/410)
MTS
P
LP
V
Y
P
V
V
---
--S
AEG
CE
L
I
L
S
D
G
RR
L
VD
GMS
SW
WAAIH
G
Y
N
HP
Q
L
N
AA
M
-
K
S
Q
IDAMS
H
VMFGGITH
A
PA
I
E
L
C
R
K
L
VAMT
P
QPL-EC
V
FLAD
SGS
V
A
V
E
V
A
M
K
M
A
L
QYWQAKGEA
-
R
QRF
L
T
F
R
N
G
YHG
D
T
--------
FG
A
MS
V
CDPDNS
M
HSLWK
G
YL
P
E
N
LFAPAPQSRMDGEWDERDMVGFARLMA-
-
AHRHEI
AA
V
I
I
EP
IV
QG
A
GG
MRMYH
PE
W
L
KR
I
R
K
I
CD
R
E
GILLI
A
DE
I
AT
G
FG
RTG
K
LFA
CEHAEIA
PD
I
L
C
L
G
K
A
L
T
GG
T
M
T
L
S
A
TL
T
T
R
EV
A
E
T
IS
N
G
E
AG
CFMH
G
P
T
FM
GNPLA
C
AAA
N
A
S
L
AILESGDWQ
Q
QVADIEV
Q
L
R
E
Q
L
AP
A
R
D
A-EMVA
DVR
V
LG
fig|316401.4.peg.976
Escherichia coli ETEC H10407 (1-344/410)
MTS
P
LP
V
Y
P
V
V
---
--S
AEG
CE
L
I
L
S
D
G
RR
L
VD
GMS
SW
WAAIH
G
Y
N
HP
Q
L
N
AA
M
-
K
S
Q
IDAMS
H
VMFGGITH
A
PA
I
E
L
C
R
K
L
VAMT
P
QPL-EC
V
FLAD
SGS
V
A
V
E
V
A
M
K
M
A
L
QYWQAKGEA
-
R
QRF
L
T
F
R
N
G
YHG
D
T
--------
FG
A
MS
V
CDPDNS
M
HSLWK
G
YL
P
E
N
LFAPAPQSRMDGEWDERDMVGFARLMA-
-
AHRHEI
AA
V
I
I
EP
IV
QG
A
GG
MRMYH
PE
W
L
KR
I
R
K
I
CD
R
E
GILLI
A
DE
I
AT
G
FG
RTG
K
LFA
CEHAEIA
PD
I
L
C
L
G
K
A
L
T
GG
T
M
T
L
S
A
TL
T
T
R
EV
A
E
T
IS
N
G
E
AG
CFMH
G
P
T
FM
GNPLA
C
AAA
N
A
S
L
AILESGDWQ
Q
QVADIEV
Q
L
R
E
Q
L
AP
A
R
D
A-EMVA
DVR
V
LG
fig|656414.3.peg.970
Escherichia coli H736 (1-344/410)
MTS
P
LP
V
Y
P
V
V
---
--S
AEG
CE
L
I
L
S
D
G
RR
L
VD
GMS
SW
WAAIH
G
Y
N
HP
Q
L
N
AA
M
-
K
S
Q
IDAMS
H
VMFGGITH
A
PA
I
E
L
C
R
K
L
VAMT
P
QPL-EC
V
FLAD
SGS
V
A
V
E
V
A
M
K
M
A
L
QYWQAKGEA
-
R
QRF
L
T
F
R
N
G
YHG
D
T
--------
FG
A
MS
V
CDPDNS
M
HSLWK
G
YL
P
E
N
LFAPAPQSRMDGEWDERDMVGFARLMA-
-
AHRHEI
AA
V
I
I
EP
IV
QG
A
GG
MRMYH
PE
W
L
KR
I
R
K
I
CD
R
E
GILLI
A
DE
I
AT
G
FG
RTG
K
LFA
CEHAEIA
PD
I
L
C
L
G
K
A
L
T
GG
T
M
T
L
S
A
TL
T
T
R
EV
A
E
T
IS
N
G
E
AG
CFMH
G
P
T
FM
GNPLA
C
AAA
N
A
S
L
AILESGDWQ
Q
QVADIEV
Q
L
R
E
Q
L
AP
A
R
D
A-EMVA
DVR
V
LG
fig|749537.3.peg.3516
Escherichia coli MS 115-1 (1-344/410)
MTS
P
LP
V
Y
P
V
V
---
--S
AEG
CE
L
I
L
S
D
G
RR
L
VD
GMS
SW
WAAIH
G
Y
N
HP
Q
L
N
AA
M
-
K
S
Q
IDAMS
H
VMFGGITH
A
PA
I
E
L
C
R
K
L
VAMT
P
QPL-EC
V
FLAD
SGS
V
A
V
E
V
A
M
K
M
A
L
QYWQAKGEA
-
R
QRF
L
T
F
R
N
G
YHG
D
T
--------
FG
A
MS
V
CDPDNS
M
HSLWK
G
YL
P
E
N
LFAPAPQSRMDGEWDERDMVGFARLMA-
-
AHRHEI
AA
V
I
I
EP
IV
QG
A
GG
MRMYH
PE
W
L
KR
I
R
K
I
CD
R
E
GILLI
A
DE
I
AT
G
FG
RTG
K
LFA
CEHAEIA
PD
I
L
C
L
G
K
A
L
T
GG
T
M
T
L
S
A
TL
T
T
R
EV
A
E
T
IS
N
G
E
AG
CFMH
G
P
T
FM
GNPLA
C
AAA
N
A
S
L
AILESGDWQ
Q
QVADIEV
Q
L
R
E
Q
L
AP
A
R
D
A-EMVA
DVR
V
LG
fig|749540.3.peg.2685
Escherichia coli MS 146-1 (1-344/410)
MTS
P
LP
V
Y
P
V
V
---
--S
AEG
CE
L
I
L
S
D
G
RR
L
VD
GMS
SW
WAAIH
G
Y
N
HP
Q
L
N
AA
M
-
K
S
Q
IDAMS
H
VMFGGITH
A
PA
I
E
L
C
R
K
L
VAMT
P
QPL-EC
V
FLAD
SGS
V
A
V
E
V
A
M
K
M
A
L
QYWQAKGEA
-
R
QRF
L
T
F
R
N
G
YHG
D
T
--------
FG
A
MS
V
CDPDNS
M
HSLWK
G
YL
P
E
N
LFAPAPQSRMDGEWDERDMVGFARLMA-
-
AHRHEI
AA
V
I
I
EP
IV
QG
A
GG
MRMYH
PE
W
L
KR
I
R
K
I
CD
R
E
GILLI
A
DE
I
AT
G
FG
RTG
K
LFA
CEHAEIA
PD
I
L
C
L
G
K
A
L
T
GG
T
M
T
L
S
A
TL
T
T
R
EV
A
E
T
IS
N
G
E
AG
CFMH
G
P
T
FM
GNPLA
C
AAA
N
A
S
L
AILESGDWQ
Q
QVADIEV
Q
L
R
E
Q
L
AP
A
R
D
A-EMVA
DVR
V
LG
fig|749544.3.peg.3323
Escherichia coli MS 175-1 (1-344/410)
MTS
P
LP
V
Y
P
V
V
---
--S
AEG
CE
L
I
L
S
D
G
RR
L
VD
GMS
SW
WAAIH
G
Y
N
HP
Q
L
N
AA
M
-
K
S
Q
IDAMS
H
VMFGGITH
A
PA
I
E
L
C
R
K
L
VAMT
P
QPL-EC
V
FLAD
SGS
V
A
V
E
V
A
M
K
M
A
L
QYWQAKGEA
-
R
QRF
L
T
F
R
N
G
YHG
D
T
--------
FG
A
MS
V
CDPDNS
M
HSLWK
G
YL
P
E
N
LFAPAPQSRMDGEWDERDMVGFARLMA-
-
AHRHEI
AA
V
I
I
EP
IV
QG
A
GG
MRMYH
PE
W
L
KR
I
R
K
I
CD
R
E
GILLI
A
DE
I
AT
G
FG
RTG
K
LFA
CEHAEIA
PD
I
L
C
L
G
K
A
L
T
GG
T
M
T
L
S
A
TL
T
T
R
EV
A
E
T
IS
N
G
E
AG
CFMH
G
P
T
FM
GNPLA
C
AAA
N
A
S
L
AILESGDWQ
Q
QVADIEV
Q
L
R
E
Q
L
AP
A
R
D
A-EMVA
DVR
V
LG
fig|749548.3.peg.2279
Escherichia coli MS 196-1 (1-344/410)
MTS
P
LP
V
Y
P
V
V
---
--S
AEG
CE
L
I
L
S
D
G
RR
L
VD
GMS
SW
WAAIH
G
Y
N
HP
Q
L
N
AA
M
-
K
S
Q
IDAMS
H
VMFGGITH
A
PA
I
E
L
C
R
K
L
VAMT
P
QPL-EC
V
FLAD
SGS
V
A
V
E
V
A
M
K
M
A
L
QYWQAKGEA
-
R
QRF
L
T
F
R
N
G
YHG
D
T
--------
FG
A
MS
V
CDPDNS
M
HSLWK
G
YL
P
E
N
LFAPAPQSRMDGEWDERDMVGFARLMA-
-
AHRHEI
AA
V
I
I
EP
IV
QG
A
GG
MRMYH
PE
W
L
KR
I
R
K
I
CD
R
E
GILLI
A
DE
I
AT
G
FG
RTG
K
LFA
CEHAEIA
PD
I
L
C
L
G
K
A
L
T
GG
T
M
T
L
S
A
TL
T
T
R
EV
A
E
T
IS
N
G
E
AG
CFMH
G
P
T
FM
GNPLA
C
AAA
N
A
S
L
AILESGDWQ
Q
QVADIEV
Q
L
R
E
Q
L
AP
A
R
D
A-EMVA
DVR
V
LG
fig|316385.5.peg.835
Escherichia coli str. K-12 substr. DH10B (1-344/410)
MTS
P
LP
V
Y
P
V
V
---
--S
AEG
CE
L
I
L
S
D
G
RR
L
VD
GMS
SW
WAAIH
G
Y
N
HP
Q
L
N
AA
M
-
K
S
Q
IDAMS
H
VMFGGITH
A
PA
I
E
L
C
R
K
L
VAMT
P
QPL-EC
V
FLAD
SGS
V
A
V
E
V
A
M
K
M
A
L
QYWQAKGEA
-
R
QRF
L
T
F
R
N
G
YHG
D
T
--------
FG
A
MS
V
CDPDNS
M
HSLWK
G
YL
P
E
N
LFAPAPQSRMDGEWDERDMVGFARLMA-
-
AHRHEI
AA
V
I
I
EP
IV
QG
A
GG
MRMYH
PE
W
L
KR
I
R
K
I
CD
R
E
GILLI
A
DE
I
AT
G
FG
RTG
K
LFA
CEHAEIA
PD
I
L
C
L
G
K
A
L
T
GG
T
M
T
L
S
A
TL
T
T
R
EV
A
E
T
IS
N
G
E
AG
CFMH
G
P
T
FM
GNPLA
C
AAA
N
A
S
L
AILESGDWQ
Q
QVADIEV
Q
L
R
E
Q
L
AP
A
R
D
A-EMVA
DVR
V
LG
fig|316385.7.peg.848
Escherichia coli str. K-12 substr. DH10B (1-344/410)
MTS
P
LP
V
Y
P
V
V
---
--S
AEG
CE
L
I
L
S
D
G
RR
L
VD
GMS
SW
WAAIH
G
Y
N
HP
Q
L
N
AA
M
-
K
S
Q
IDAMS
H
VMFGGITH
A
PA
I
E
L
C
R
K
L
VAMT
P
QPL-EC
V
FLAD
SGS
V
A
V
E
V
A
M
K
M
A
L
QYWQAKGEA
-
R
QRF
L
T
F
R
N
G
YHG
D
T
--------
FG
A
MS
V
CDPDNS
M
HSLWK
G
YL
P
E
N
LFAPAPQSRMDGEWDERDMVGFARLMA-
-
AHRHEI
AA
V
I
I
EP
IV
QG
A
GG
MRMYH
PE
W
L
KR
I
R
K
I
CD
R
E
GILLI
A
DE
I
AT
G
FG
RTG
K
LFA
CEHAEIA
PD
I
L
C
L
G
K
A
L
T
GG
T
M
T
L
S
A
TL
T
T
R
EV
A
E
T
IS
N
G
E
AG
CFMH
G
P
T
FM
GNPLA
C
AAA
N
A
S
L
AILESGDWQ
Q
QVADIEV
Q
L
R
E
Q
L
AP
A
R
D
A-EMVA
DVR
V
LG
fig|511145.12.peg.800
Escherichia coli str. K-12 substr. MG1655 (1-344/410)
MTS
P
LP
V
Y
P
V
V
---
--S
AEG
CE
L
I
L
S
D
G
RR
L
VD
GMS
SW
WAAIH
G
Y
N
HP
Q
L
N
AA
M
-
K
S
Q
IDAMS
H
VMFGGITH
A
PA
I
E
L
C
R
K
L
VAMT
P
QPL-EC
V
FLAD
SGS
V
A
V
E
V
A
M
K
M
A
L
QYWQAKGEA
-
R
QRF
L
T
F
R
N
G
YHG
D
T
--------
FG
A
MS
V
CDPDNS
M
HSLWK
G
YL
P
E
N
LFAPAPQSRMDGEWDERDMVGFARLMA-
-
AHRHEI
AA
V
I
I
EP
IV
QG
A
GG
MRMYH
PE
W
L
KR
I
R
K
I
CD
R
E
GILLI
A
DE
I
AT
G
FG
RTG
K
LFA
CEHAEIA
PD
I
L
C
L
G
K
A
L
T
GG
T
M
T
L
S
A
TL
T
T
R
EV
A
E
T
IS
N
G
E
AG
CFMH
G
P
T
FM
GNPLA
C
AAA
N
A
S
L
AILESGDWQ
Q
QVADIEV
Q
L
R
E
Q
L
AP
A
R
D
A-EMVA
DVR
V
LG
fig|511145.6.peg.791
Escherichia coli str. K-12 substr. MG1655 (1-344/410)
MTS
P
LP
V
Y
P
V
V
---
--S
AEG
CE
L
I
L
S
D
G
RR
L
VD
GMS
SW
WAAIH
G
Y
N
HP
Q
L
N
AA
M
-
K
S
Q
IDAMS
H
VMFGGITH
A
PA
I
E
L
C
R
K
L
VAMT
P
QPL-EC
V
FLAD
SGS
V
A
V
E
V
A
M
K
M
A
L
QYWQAKGEA
-
R
QRF
L
T
F
R
N
G
YHG
D
T
--------
FG
A
MS
V
CDPDNS
M
HSLWK
G
YL
P
E
N
LFAPAPQSRMDGEWDERDMVGFARLMA-
-
AHRHEI
AA
V
I
I
EP
IV
QG
A
GG
MRMYH
PE
W
L
KR
I
R
K
I
CD
R
E
GILLI
A
DE
I
AT
G
FG
RTG
K
LFA
CEHAEIA
PD
I
L
C
L
G
K
A
L
T
GG
T
M
T
L
S
A
TL
T
T
R
EV
A
E
T
IS
N
G
E
AG
CFMH
G
P
T
FM
GNPLA
C
AAA
N
A
S
L
AILESGDWQ
Q
QVADIEV
Q
L
R
E
Q
L
AP
A
R
D
A-EMVA
DVR
V
LG
fig|83333.1.peg.760
Escherichia coli K12 (20-363/429)
MTS
P
LP
V
Y
P
V
V
---
--S
AEG
CE
L
I
L
S
D
G
RR
L
VD
GMS
SW
WAAIH
G
Y
N
HP
Q
L
N
AA
M
-
K
S
Q
IDAMS
H
VMFGGITH
A
PA
I
E
L
C
R
K
L
VAMT
P
QPL-EC
V
FLAD
SGS
V
A
V
E
V
A
M
K
M
A
L
QYWQAKGEA
-
R
QRF
L
T
F
R
N
G
YHG
D
T
--------
FG
A
MS
V
CDPDNS
M
HSLWK
G
YL
P
E
N
LFAPAPQSRMDGEWDERDMVGFARLMA-
-
AHRHEI
AA
V
I
I
EP
IV
QG
A
GG
MRMYH
PE
W
L
KR
I
R
K
I
CD
R
E
GILLI
A
DE
I
AT
G
FG
RTG
K
LFA
CEHAEIA
PD
I
L
C
L
G
K
A
L
T
GG
T
M
T
L
S
A
TL
T
T
R
EV
A
E
T
IS
N
G
E
AG
CFMH
G
P
T
FM
GNPLA
C
AAA
N
A
S
L
AILESGDWQ
Q
QVADIEV
Q
L
R
E
Q
L
AP
A
R
D
A-EMVA
DVR
V
LG
fig|749538.3.peg.759
Escherichia coli MS 116-1 (20-363/429)
MTS
P
LP
V
Y
P
V
V
---
--S
AEG
CE
L
I
L
S
D
G
RR
L
VD
GMS
SW
WAAIH
G
Y
N
HP
Q
L
N
AA
M
-
K
S
Q
IDAMS
H
VMFGGITH
A
PA
I
E
L
C
R
K
L
VAMT
P
QPL-EC
V
FLAD
SGS
V
A
V
E
V
A
M
K
M
A
L
QYWQAKGEA
-
R
QRF
L
T
F
R
N
G
YHG
D
T
--------
FG
A
MS
V
CDPDNS
M
HSLWK
G
YL
P
E
N
LFAPAPQSRMDGEWDERDMVGFARLMA-
-
AHRHEI
AA
V
I
I
EP
IV
QG
A
GG
MRMYH
PE
W
L
KR
I
R
K
I
CD
R
E
GILLI
A
DE
I
AT
G
FG
RTG
K
LFA
CEHAEIA
PD
I
L
C
L
G
K
A
L
T
GG
T
M
T
L
S
A
TL
T
T
R
EV
A
E
T
IS
N
G
E
AG
CFMH
G
P
T
FM
GNPLA
C
AAA
N
A
S
L
AILESGDWQ
Q
QVADIEV
Q
L
R
E
Q
L
AP
A
R
D
A-EMVA
DVR
V
LG
fig|316407.3.peg.741
Escherichia coli W3110 (20-363/429)
MTS
P
LP
V
Y
P
V
V
---
--S
AEG
CE
L
I
L
S
D
G
RR
L
VD
GMS
SW
WAAIH
G
Y
N
HP
Q
L
N
AA
M
-
K
S
Q
IDAMS
H
VMFGGITH
A
PA
I
E
L
C
R
K
L
VAMT
P
QPL-EC
V
FLAD
SGS
V
A
V
E
V
A
M
K
M
A
L
QYWQAKGEA
-
R
QRF
L
T
F
R
N
G
YHG
D
T
--------
FG
A
MS
V
CDPDNS
M
HSLWK
G
YL
P
E
N
LFAPAPQSRMDGEWDERDMVGFARLMA-
-
AHRHEI
AA
V
I
I
EP
IV
QG
A
GG
MRMYH
PE
W
L
KR
I
R
K
I
CD
R
E
GILLI
A
DE
I
AT
G
FG
RTG
K
LFA
CEHAEIA
PD
I
L
C
L
G
K
A
L
T
GG
T
M
T
L
S
A
TL
T
T
R
EV
A
E
T
IS
N
G
E
AG
CFMH
G
P
T
FM
GNPLA
C
AAA
N
A
S
L
AILESGDWQ
Q
QVADIEV
Q
L
R
E
Q
L
AP
A
R
D
A-EMVA
DVR
V
LG
fig|344601.5.peg.4572
Escherichia coli B171 (1-344/410)
MTS
P
LP
V
Y
P
V
A
---
--S
AEG
CE
L
I
L
S
D
G
RR
L
VD
GMS
SW
WAAIH
G
Y
N
HP
Q
L
N
AA
M
-
K
T
Q
IDAMS
H
VMFGGITH
A
PA
I
E
L
C
R
K
L
VAMT
P
QPL-EC
V
FLAD
SGS
V
A
V
E
V
A
M
K
M
A
L
QYWQAKGEA
-
R
QRF
L
T
F
R
N
G
YHG
D
T
--------
FG
A
MS
V
CDPDNS
M
HSLWK
G
YL
P
E
N
LFAPAPQSRMDGEWDERDMVGFARLMA-
-
AHRHEI
AA
V
I
I
EP
IV
QG
A
GG
MRMYH
PE
W
L
KR
I
R
K
M
CD
R
E
GILLI
A
DE
I
AT
G
FG
RTG
K
LFA
CEYAEIA
PD
I
L
C
L
G
K
A
L
T
GG
T
M
T
L
S
A
TL
T
T
R
EV
A
E
T
IS
N
G
E
AG
CFMH
G
P
T
FM
GNPLA
C
AAA
N
A
S
L
AIIESGEWQ
Q
QVAAIEV
Q
L
R
E
Q
L
AP
A
R
D
A-EMVA
DVR
V
LG
fig|340185.4.peg.5220
Escherichia coli E22 (1-344/410)
MTS
P
LP
V
Y
P
V
A
---
--S
AEG
CE
L
I
L
S
D
G
RR
L
VD
GMS
SW
WAAIH
G
Y
N
HP
Q
L
N
AA
M
-
K
T
Q
IDAMS
H
VMFGGITH
A
PA
I
E
L
C
R
K
L
VAMT
P
QPL-EC
V
FLAD
SGS
V
A
V
E
V
A
M
K
M
A
L
QYWQAKGEA
-
R
QRF
L
T
F
R
N
G
YHG
D
T
--------
FG
A
MS
V
CDPDNS
M
HSLWK
G
YL
P
E
N
LFAPAPQSRMDGEWDERDMVGFARLMA-
-
AHRHEI
AA
V
I
I
EP
IV
QG
A
GG
MRMYH
PE
W
L
KR
I
R
K
M
CD
R
E
GILLI
A
DE
I
AT
G
FG
RTG
K
LFA
CEYAEIA
PD
I
L
C
L
G
K
A
L
T
GG
T
M
T
L
S
A
TL
T
T
R
EV
A
E
T
IS
N
G
E
AG
CFMH
G
P
T
FM
GNPLA
C
AAA
N
A
S
L
AIIESGEWQ
Q
QVAAIEV
Q
L
R
E
Q
L
AP
A
R
D
A-EMVA
DVR
V
LG
fig|585395.4.peg.854
Escherichia coli O103:H2 str. 12009 (20-363/429)
MTS
P
LP
V
Y
P
V
A
---
--S
AEG
CE
L
I
L
S
D
G
RR
L
VD
GMS
SW
WAAIH
G
Y
N
HP
Q
L
N
AA
M
-
K
T
Q
IDAMS
H
VMFGGITH
A
PA
I
E
L
C
R
K
L
VAMT
P
QPL-EC
V
FLAD
SGS
V
A
V
E
V
A
M
K
M
A
L
QYWQAKGEA
-
R
QRF
L
T
F
R
N
G
YHG
D
T
--------
FG
A
MS
V
CDPDNS
M
HSLWK
G
YL
P
E
N
LFAPAPQSRMDGEWDERDMVGFARLMA-
-
AHRHEI
AA
V
I
I
EP
IV
QG
A
GG
MRMYH
PE
W
L
KR
I
R
K
M
CD
R
E
GILLI
A
DE
I
AT
G
FG
RTG
K
LFA
CEYAEIA
PD
I
L
C
L
G
K
A
L
T
GG
T
M
T
L
S
A
TL
T
T
R
EV
A
E
T
IS
N
G
E
AG
CFMH
G
P
T
FM
GNPLA
C
AAA
N
A
S
L
AIIESGEWQ
Q
QVAAIEV
Q
L
R
E
Q
L
AP
A
R
D
A-EMVA
DVR
V
LG
fig|344601.3.peg.4340
Escherichia coli B171 (57-400/466)
MTS
P
LP
V
Y
P
V
A
---
--S
AEG
CE
L
I
L
S
D
G
RR
L
VD
GMS
SW
WAAIH
G
Y
N
HP
Q
L
N
AA
M
-
K
T
Q
IDAMS
H
VMFGGITH
A
PA
I
E
L
C
R
K
L
VAMT
P
QPL-EC
V
FLAD
SGS
V
A
V
E
V
A
M
K
M
A
L
QYWQAKGEA
-
R
QRF
L
T
F
R
N
G
YHG
D
T
--------
FG
A
MS
V
CDPDNS
M
HSLWK
G
YL
P
E
N
LFAPAPQSRMDGEWDERDMVGFARLMA-
-
AHRHEI
AA
V
I
I
EP
IV
QG
A
GG
MRMYH
PE
W
L
KR
I
R
K
M
CD
R
E
GILLI
A
DE
I
AT
G
FG
RTG
K
LFA
CEYAEIA
PD
I
L
C
L
G
K
A
L
T
GG
T
M
T
L
S
A
TL
T
T
R
EV
A
E
T
IS
N
G
E
AG
CFMH
G
P
T
FM
GNPLA
C
AAA
N
A
S
L
AIIESGEWQ
Q
QVAAIEV
Q
L
R
E
Q
L
AP
A
R
D
A-EMVA
DVR
V
LG
fig|340185.3.peg.4936
Escherichia coli E22 (57-400/466)
MTS
P
LP
V
Y
P
V
A
---
--S
AEG
CE
L
I
L
S
D
G
RR
L
VD
GMS
SW
WAAIH
G
Y
N
HP
Q
L
N
AA
M
-
K
T
Q
IDAMS
H
VMFGGITH
A
PA
I
E
L
C
R
K
L
VAMT
P
QPL-EC
V
FLAD
SGS
V
A
V
E
V
A
M
K
M
A
L
QYWQAKGEA
-
R
QRF
L
T
F
R
N
G
YHG
D
T
--------
FG
A
MS
V
CDPDNS
M
HSLWK
G
YL
P
E
N
LFAPAPQSRMDGEWDERDMVGFARLMA-
-
AHRHEI
AA
V
I
I
EP
IV
QG
A
GG
MRMYH
PE
W
L
KR
I
R
K
M
CD
R
E
GILLI
A
DE
I
AT
G
FG
RTG
K
LFA
CEYAEIA
PD
I
L
C
L
G
K
A
L
T
GG
T
M
T
L
S
A
TL
T
T
R
EV
A
E
T
IS
N
G
E
AG
CFMH
G
P
T
FM
GNPLA
C
AAA
N
A
S
L
AIIESGEWQ
Q
QVAAIEV
Q
L
R
E
Q
L
AP
A
R
D
A-EMVA
DVR
V
LG
fig|216592.3.peg.884
Escherichia coli 042 (1-344/410)
MTS
P
LP
V
Y
P
V
A
---
--S
AEG
CE
L
I
L
S
D
G
RR
L
VD
GMS
SW
WAAIH
G
Y
N
HP
Q
L
N
AA
M
-
K
S
Q
IDAMS
H
VMFGGITH
A
PA
I
E
L
C
R
K
L
VAMT
P
QPL-EC
V
FLAD
SGS
V
A
V
E
V
A
M
K
M
A
L
QYWQAKGEA
-
R
QRF
L
T
F
R
N
G
YHG
D
T
--------
FG
A
MS
V
CDPDNS
M
HSLWK
G
YL
P
E
N
LFAPAPQSRMDGEWDERDMVGFARLMA-
-
AHRHEI
AA
V
I
I
EP
IV
QG
A
GG
MRIYH
PE
W
L
KR
I
R
K
M
CD
R
E
GILLI
A
DE
I
AT
G
FG
RTG
K
LFA
CEHADIA
PD
I
L
C
L
G
K
A
L
T
GG
T
M
T
L
S
A
TL
T
T
R
EV
A
E
T
IS
N
G
E
AG
CFMH
G
P
T
FM
GNPLA
C
AAA
N
A
S
L
AILESGDWQ
Q
QVVAIEV
Q
L
R
E
Q
L
AP
A
R
D
A-KMVA
DVR
V
LG
fig|656379.3.peg.1608
Escherichia coli FVEC1302 (1-344/410)
MTS
P
LP
V
Y
P
V
A
---
--S
AEG
CE
L
I
L
S
D
G
RR
L
VD
GMS
SW
WAAIH
G
Y
N
HP
Q
L
N
AA
M
-
K
S
Q
IDAMS
H
VMFGGITH
A
PA
I
E
L
C
R
K
L
VAMT
P
QPL-EC
V
FLAD
SGS
V
A
V
E
V
A
M
K
M
A
L
QYWQAKGEA
-
R
QRF
L
T
F
R
N
G
YHG
D
T
--------
FG
A
MS
V
CDPDNS
M
HSLWK
G
YL
P
E
N
LFAPAPQSRMDGEWDERDMVGFARLMA-
-
AHRHEI
AA
V
I
I
EP
IV
QG
A
GG
MRIYH
PE
W
L
KR
I
R
K
M
CD
R
E
GILLI
A
DE
I
AT
G
FG
RTG
K
LFA
CEHADIA
PD
I
L
C
L
G
K
A
L
T
GG
T
M
T
L
S
A
TL
T
T
R
EV
A
E
T
IS
N
G
E
AG
CFMH
G
P
T
FM
GNPLA
C
AAA
N
A
S
L
AILESGDWQ
Q
QVVAIEV
Q
L
R
E
Q
L
AP
A
R
D
A-KMVA
DVR
V
LG
fig|656380.3.peg.1436
Escherichia coli FVEC1412 (1-344/410)
MTS
P
LP
V
Y
P
V
A
---
--S
AEG
CE
L
I
L
S
D
G
RR
L
VD
GMS
SW
WAAIH
G
Y
N
HP
Q
L
N
AA
M
-
K
S
Q
IDAMS
H
VMFGGITH
A
PA
I
E
L
C
R
K
L
VAMT
P
QPL-EC
V
FLAD
SGS
V
A
V
E
V
A
M
K
M
A
L
QYWQAKGEA
-
R
QRF
L
T
F
R
N
G
YHG
D
T
--------
FG
A
MS
V
CDPDNS
M
HSLWK
G
YL
P
E
N
LFAPAPQSRMDGEWDERDMVGFARLMA-
-
AHRHEI
AA
V
I
I
EP
IV
QG
A
GG
MRIYH
PE
W
L
KR
I
R
K
M
CD
R
E
GILLI
A
DE
I
AT
G
FG
RTG
K
LFA
CEHADIA
PD
I
L
C
L
G
K
A
L
T
GG
T
M
T
L
S
A
TL
T
T
R
EV
A
E
T
IS
N
G
E
AG
CFMH
G
P
T
FM
GNPLA
C
AAA
N
A
S
L
AILESGDWQ
Q
QVVAIEV
Q
L
R
E
Q
L
AP
A
R
D
A-KMVA
DVR
V
LG
fig|749549.3.peg.2288
Escherichia coli MS 198-1 (1-344/410)
MTS
P
LP
V
Y
P
V
A
---
--S
AEG
CE
L
I
L
S
D
G
RR
L
VD
GMS
SW
WAAIH
G
Y
N
HP
Q
L
N
AA
M
-
K
S
Q
IDAMS
H
VMFGGITH
A
PA
I
E
L
C
R
K
L
VAMT
P
QPL-EC
V
FLAD
SGS
V
A
V
E
V
A
M
K
M
A
L
QYWQAKGEA
-
R
QRF
L
T
F
R
N
G
YHG
D
T
--------
FG
A
MS
V
CDPDNS
M
HSLWK
G
YL
P
E
N
LFAPAPQSRMDGEWDERDMVGFARLMA-
-
AHRHEI
AA
V
I
I
EP
IV
QG
A
GG
MRIYH
PE
W
L
KR
I
R
K
M
CD
R
E
GILLI
A
DE
I
AT
G
FG
RTG
K
LFA
CEHADIA
PD
I
L
C
L
G
K
A
L
T
GG
T
M
T
L
S
A
TL
T
T
R
EV
A
E
T
IS
N
G
E
AG
CFMH
G
P
T
FM
GNPLA
C
AAA
N
A
S
L
AILESGDWQ
Q
QVVAIEV
Q
L
R
E
Q
L
AP
A
R
D
A-KMVA
DVR
V
LG
fig|656437.3.peg.853
Escherichia coli TA143 (1-344/410)
MTS
P
LP
V
Y
P
V
A
---
--S
AEG
CE
L
I
L
S
D
G
RR
L
VD
GMS
SW
WAAIH
G
Y
N
HP
Q
L
N
AA
M
-
K
S
Q
IDAMS
H
VMFGGITH
A
PA
I
E
L
C
R
K
L
VAMT
P
QPL-EC
V
FLAD
SGS
V
A
V
E
V
A
M
K
M
A
L
QYWQAKGEA
-
R
QRF
L
T
F
R
N
G
YHG
D
T
--------
FG
A
MS
V
CDPDNS
M
HSLWK
G
YL
P
E
N
LFAPAPQSRMDGEWDERDMVGFARLMA-
-
AHRHEI
AA
V
I
I
EP
IV
QG
A
GG
MRIYH
PE
W
L
KR
I
R
K
M
CD
R
E
GILLI
A
DE
I
AT
G
FG
RTG
K
LFA
CEHADIA
PD
I
L
C
L
G
K
A
L
T
GG
T
M
T
L
S
A
TL
T
T
R
EV
A
E
T
IS
N
G
E
AG
CFMH
G
P
T
FM
GNPLA
C
AAA
N
A
S
L
AILESGDWQ
Q
QVVAIEV
Q
L
R
E
Q
L
AP
A
R
D
A-KMVA
DVR
V
LG
fig|585056.7.peg.1111
Escherichia coli UMN026 (1-344/410)
MTS
P
LP
V
Y
P
V
A
---
--S
AEG
CE
L
I
L
S
D
G
RR
L
VD
GMS
SW
WAAIH
G
Y
N
HP
Q
L
N
AA
M
-
K
S
Q
IDAMS
H
VMFGGITH
A
PA
I
E
L
C
R
K
L
VAMT
P
QPL-EC
V
FLAD
SGS
V
A
V
E
V
A
M
K
M
A
L
QYWQAKGEA
-
R
QRF
L
T
F
R
N
G
YHG
D
T
--------
FG
A
MS
V
CDPDNS
M
HSLWK
G
YL
P
E
N
LFAPAPQSRMDGEWDERDMVGFARLMA-
-
AHRHEI
AA
V
I
I
EP
IV
QG
A
GG
MRIYH
PE
W
L
KR
I
R
K
M
CD
R
E
GILLI
A
DE
I
AT
G
FG
RTG
K
LFA
CEHADIA
PD
I
L
C
L
G
K
A
L
T
GG
T
M
T
L
S
A
TL
T
T
R
EV
A
E
T
IS
N
G
E
AG
CFMH
G
P
T
FM
GNPLA
C
AAA
N
A
S
L
AILESGDWQ
Q
QVVAIEV
Q
L
R
E
Q
L
AP
A
R
D
A-KMVA
DVR
V
LG
fig|216592.1.peg.3289
Escherichia coli 042 (57-400/466)
MTS
P
LP
V
Y
P
V
A
---
--S
AEG
CE
L
I
L
S
D
G
RR
L
VD
GMS
SW
WAAIH
G
Y
N
HP
Q
L
N
AA
M
-
K
S
Q
IDAMS
H
VMFGGITH
A
PA
I
E
L
C
R
K
L
VAMT
P
QPL-EC
V
FLAD
SGS
V
A
V
E
V
A
M
K
M
A
L
QYWQAKGEA
-
R
QRF
L
T
F
R
N
G
YHG
D
T
--------
FG
A
MS
V
CDPDNS
M
HSLWK
G
YL
P
E
N
LFAPAPQSRMDGEWDERDMVGFARLMA-
-
AHRHEI
AA
V
I
I
EP
IV
QG
A
GG
MRIYH
PE
W
L
KR
I
R
K
M
CD
R
E
GILLI
A
DE
I
AT
G
FG
RTG
K
LFA
CEHADIA
PD
I
L
C
L
G
K
A
L
T
GG
T
M
T
L
S
A
TL
T
T
R
EV
A
E
T
IS
N
G
E
AG
CFMH
G
P
T
FM
GNPLA
C
AAA
N
A
S
L
AILESGDWQ
Q
QVVAIEV
Q
L
R
E
Q
L
AP
A
R
D
A-KMVA
DVR
V
LG
fig|525281.3.peg.2181
Escherichia coli 83972 (1-344/410)
MTS
P
LP
V
Y
P
V
A
---
--S
AEG
CE
L
I
L
S
D
G
RR
L
VD
GMS
SW
WAAIH
G
Y
N
HP
Q
L
N
AA
M
-
K
S
Q
IDAMS
H
VMFGGITH
A
PA
I
E
L
C
R
K
L
VAMT
P
QPL-EC
V
FLAD
SGS
V
A
V
E
V
A
M
K
M
A
L
QYWQAKGEA
-
R
QRF
L
T
F
R
N
G
YHG
D
T
--------
FG
A
MS
V
CDPDNS
M
HSLWK
G
YL
P
E
N
LFAPAPQSRMDGEWDERDMVGFARLMA-
-
AHRHEI
AA
V
I
I
EP
IV
QG
A
GG
MRMYH
PE
W
L
KR
I
R
K
M
CD
R
E
GILLI
A
DE
I
AT
G
FG
RTG
K
LFA
CEHAEIA
PD
I
L
C
L
G
K
A
L
T
GG
T
M
T
L
S
A
TL
T
T
R
EV
A
E
T
IS
N
G
E
AG
CFMH
G
P
T
FM
GNPLA
C
AAA
N
A
S
L
AILESGDWQ
H
QVAAIEA
Q
L
R
E
Q
L
AP
A
C
D
A-EMVA
DVR
V
LG
fig|655817.3.peg.857
Escherichia coli ABU 83972 (1-344/410)
MTS
P
LP
V
Y
P
V
A
---
--S
AEG
CE
L
I
L
S
D
G
RR
L
VD
GMS
SW
WAAIH
G
Y
N
HP
Q
L
N
AA
M
-
K
S
Q
IDAMS
H
VMFGGITH
A
PA
I
E
L
C
R
K
L
VAMT
P
QPL-EC
V
FLAD
SGS
V
A
V
E
V
A
M
K
M
A
L
QYWQAKGEA
-
R
QRF
L
T
F
R
N
G
YHG
D
T
--------
FG
A
MS
V
CDPDNS
M
HSLWK
G
YL
P
E
N
LFAPAPQSRMDGEWDERDMVGFARLMA-
-
AHRHEI
AA
V
I
I
EP
IV
QG
A
GG
MRMYH
PE
W
L
KR
I
R
K
M
CD
R
E
GILLI
A
DE
I
AT
G
FG
RTG
K
LFA
CEHAEIA
PD
I
L
C
L
G
K
A
L
T
GG
T
M
T
L
S
A
TL
T
T
R
EV
A
E
T
IS
N
G
E
AG
CFMH
G
P
T
FM
GNPLA
C
AAA
N
A
S
L
AILESGDWQ
H
QVAAIEA
Q
L
R
E
Q
L
AP
A
C
D
A-EMVA
DVR
V
LG
fig|405955.13.peg.731
Escherichia coli APEC O1 (1-344/410)
MTS
P
LP
V
Y
P
V
A
---
--S
AEG
CE
L
I
L
S
D
G
RR
L
VD
GMS
SW
WAAIH
G
Y
N
HP
Q
L
N
AA
M
-
K
S
Q
IDAMS
H
VMFGGITH
A
PA
I
E
L
C
R
K
L
VAMT
P
QPL-EC
V
FLAD
SGS
V
A
V
E
V
A
M
K
M
A
L
QYWQAKGEA
-
R
QRF
L
T
F
R
N
G
YHG
D
T
--------
FG
A
MS
V
CDPDNS
M
HSLWK
G
YL
P
E
N
LFAPAPQSRMDGEWDERDMVGFARLMA-
-
AHRHEI
AA
V
I
I
EP
IV
QG
A
GG
MRMYH
PE
W
L
KR
I
R
K
M
CD
R
E
GILLI
A
DE
I
AT
G
FG
RTG
K
LFA
CEHAEIA
PD
I
L
C
L
G
K
A
L
T
GG
T
M
T
L
S
A
TL
T
T
R
EV
A
E
T
IS
N
G
E
AG
CFMH
G
P
T
FM
GNPLA
C
AAA
N
A
S
L
AILESGDWQ
H
QVAAIEA
Q
L
R
E
Q
L
AP
A
C
D
A-EMVA
DVR
V
LG
fig|199310.4.peg.811
Escherichia coli CFT073 (1-344/410)
MTS
P
LP
V
Y
P
V
A
---
--S
AEG
CE
L
I
L
S
D
G
RR
L
VD
GMS
SW
WAAIH
G
Y
N
HP
Q
L
N
AA
M
-
K
S
Q
IDAMS
H
VMFGGITH
A
PA
I
E
L
C
R
K
L
VAMT
P
QPL-EC
V
FLAD
SGS
V
A
V
E
V
A
M
K
M
A
L
QYWQAKGEA
-
R
QRF
L
T
F
R
N
G
YHG
D
T
--------
FG
A
MS
V
CDPDNS
M
HSLWK
G
YL
P
E
N
LFAPAPQSRMDGEWDERDMVGFARLMA-
-
AHRHEI
AA
V
I
I
EP
IV
QG
A
GG
MRMYH
PE
W
L
KR
I
R
K
M
CD
R
E
GILLI
A
DE
I
AT
G
FG
RTG
K
LFA
CEHAEIA
PD
I
L
C
L
G
K
A
L
T
GG
T
M
T
L
S
A
TL
T
T
R
EV
A
E
T
IS
N
G
E
AG
CFMH
G
P
T
FM
GNPLA
C
AAA
N
A
S
L
AILESGDWQ
H
QVAAIEA
Q
L
R
E
Q
L
AP
A
C
D
A-EMVA
DVR
V
LG
fig|714962.3.peg.779
Escherichia coli IHE3034 (1-344/410)
MTS
P
LP
V
Y
P
V
A
---
--S
AEG
CE
L
I
L
S
D
G
RR
L
VD
GMS
SW
WAAIH
G
Y
N
HP
Q
L
N
AA
M
-
K
S
Q
IDAMS
H
VMFGGITH
A
PA
I
E
L
C
R
K
L
VAMT
P
QPL-EC
V
FLAD
SGS
V
A
V
E
V
A
M
K
M
A
L
QYWQAKGEA
-
R
QRF
L
T
F
R
N
G
YHG
D
T
--------
FG
A
MS
V
CDPDNS
M
HSLWK
G
YL
P
E
N
LFAPAPQSRMDGEWDERDMVGFARLMA-
-
AHRHEI
AA
V
I
I
EP
IV
QG
A
GG
MRMYH
PE
W
L
KR
I
R
K
M
CD
R
E
GILLI
A
DE
I
AT
G
FG
RTG
K
LFA
CEHAEIA
PD
I
L
C
L
G
K
A
L
T
GG
T
M
T
L
S
A
TL
T
T
R
EV
A
E
T
IS
N
G
E
AG
CFMH
G
P
T
FM
GNPLA
C
AAA
N
A
S
L
AILESGDWQ
H
QVAAIEA
Q
L
R
E
Q
L
AP
A
C
D
A-EMVA
DVR
V
LG
fig|749546.3.peg.4990
Escherichia coli MS 185-1 (1-344/410)
MTS
P
LP
V
Y
P
V
A
---
--S
AEG
CE
L
I
L
S
D
G
RR
L
VD
GMS
SW
WAAIH
G
Y
N
HP
Q
L
N
AA
M
-
K
S
Q
IDAMS
H
VMFGGITH
A
PA
I
E
L
C
R
K
L
VAMT
P
QPL-EC
V
FLAD
SGS
V
A
V
E
V
A
M
K
M
A
L
QYWQAKGEA
-
R
QRF
L
T
F
R
N
G
YHG
D
T
--------
FG
A
MS
V
CDPDNS
M
HSLWK
G
YL
P
E
N
LFAPAPQSRMDGEWDERDMVGFARLMA-
-
AHRHEI
AA
V
I
I
EP
IV
QG
A
GG
MRMYH
PE
W
L
KR
I
R
K
M
CD
R
E
GILLI
A
DE
I
AT
G
FG
RTG
K
LFA
CEHAEIA
PD
I
L
C
L
G
K
A
L
T
GG
T
M
T
L
S
A
TL
T
T
R
EV
A
E
T
IS
N
G
E
AG
CFMH
G
P
T
FM
GNPLA
C
AAA
N
A
S
L
AILESGDWQ
H
QVAAIEA
Q
L
R
E
Q
L
AP
A
C
D
A-EMVA
DVR
V
LG
fig|749528.3.peg.4510
Escherichia coli MS 45-1 (1-344/410)
MTS
P
LP
V
Y
P
V
A
---
--S
AEG
CE
L
I
L
S
D
G
RR
L
VD
GMS
SW
WAAIH
G
Y
N
HP
Q
L
N
AA
M
-
K
S
Q
IDAMS
H
VMFGGITH
A
PA
I
E
L
C
R
K
L
VAMT
P
QPL-EC
V
FLAD
SGS
V
A
V
E
V
A
M
K
M
A
L
QYWQAKGEA
-
R
QRF
L
T
F
R
N
G
YHG
D
T
--------
FG
A
MS
V
CDPDNS
M
HSLWK
G
YL
P
E
N
LFAPAPQSRMDGEWDERDMVGFARLMA-
-
AHRHEI
AA
V
I
I
EP
IV
QG
A
GG
MRMYH
PE
W
L
KR
I
R
K
M
CD
R
E
GILLI
A
DE
I
AT
G
FG
RTG
K
LFA
CEHAEIA
PD
I
L
C
L
G
K
A
L
T
GG
T
M
T
L
S
A
TL
T
T
R
EV
A
E
T
IS
N
G
E
AG
CFMH
G
P
T
FM
GNPLA
C
AAA
N
A
S
L
AILESGDWQ
H
QVAAIEA
Q
L
R
E
Q
L
AP
A
C
D
A-EMVA
DVR
V
LG
fig|753642.3.peg.893
Escherichia coli NC101 (1-344/410)
MTS
P
LP
V
Y
P
V
A
---
--S
AEG
CE
L
I
L
S
D
G
RR
L
VD
GMS
SW
WAAIH
G
Y
N
HP
Q
L
N
AA
M
-
K
S
Q
IDAMS
H
VMFGGITH
A
PA
I
E
L
C
R
K
L
VAMT
P
QPL-EC
V
FLAD
SGS
V
A
V
E
V
A
M
K
M
A
L
QYWQAKGEA
-
R
QRF
L
T
F
R
N
G
YHG
D
T
--------
FG
A
MS
V
CDPDNS
M
HSLWK
G
YL
P
E
N
LFAPAPQSRMDGEWDERDMVGFARLMA-
-
AHRHEI
AA
V
I
I
EP
IV
QG
A
GG
MRMYH
PE
W
L
KR
I
R
K
M
CD
R
E
GILLI
A
DE
I
AT
G
FG
RTG
K
LFA
CEHAEIA
PD
I
L
C
L
G
K
A
L
T
GG
T
M
T
L
S
A
TL
T
T
R
EV
A
E
T
IS
N
G
E
AG
CFMH
G
P
T
FM
GNPLA
C
AAA
N
A
S
L
AILESGDWQ
H
QVAAIEA
Q
L
R
E
Q
L
AP
A
C
D
A-EMVA
DVR
V
LG
fig|685038.3.peg.699
Escherichia coli O83:H1 str. NRG 857C (1-344/410)
MTS
P
LP
V
Y
P
V
A
---
--S
AEG
CE
L
I
L
S
D
G
RR
L
VD
GMS
SW
WAAIH
G
Y
N
HP
Q
L
N
AA
M
-
K
S
Q
IDAMS
H
VMFGGITH
A
PA
I
E
L
C
R
K
L
VAMT
P
QPL-EC
V
FLAD
SGS
V
A
V
E
V
A
M
K
M
A
L
QYWQAKGEA
-
R
QRF
L
T
F
R
N
G
YHG
D
T
--------
FG
A
MS
V
CDPDNS
M
HSLWK
G
YL
P
E
N
LFAPAPQSRMDGEWDERDMVGFARLMA-
-
AHRHEI
AA
V
I
I
EP
IV
QG
A
GG
MRMYH
PE
W
L
KR
I
R
K
M
CD
R
E
GILLI
A
DE
I
AT
G
FG
RTG
K
LFA
CEHAEIA
PD
I
L
C
L
G
K
A
L
T
GG
T
M
T
L
S
A
TL
T
T
R
EV
A
E
T
IS
N
G
E
AG
CFMH
G
P
T
FM
GNPLA
C
AAA
N
A
S
L
AILESGDWQ
H
QVAAIEA
Q
L
R
E
Q
L
AP
A
C
D
A-EMVA
DVR
V
LG
fig|585035.6.peg.791
Escherichia coli S88 (1-344/410)
MTS
P
LP
V
Y
P
V
A
---
--S
AEG
CE
L
I
L
S
D
G
RR
L
VD
GMS
SW
WAAIH
G
Y
N
HP
Q
L
N
AA
M
-
K
S
Q
IDAMS
H
VMFGGITH
A
PA
I
E
L
C
R
K
L
VAMT
P
QPL-EC
V
FLAD
SGS
V
A
V
E
V
A
M
K
M
A
L
QYWQAKGEA
-
R
QRF
L
T
F
R
N
G
YHG
D
T
--------
FG
A
MS
V
CDPDNS
M
HSLWK
G
YL
P
E
N
LFAPAPQSRMDGEWDERDMVGFARLMA-
-
AHRHEI
AA
V
I
I
EP
IV
QG
A
GG
MRMYH
PE
W
L
KR
I
R
K
M
CD
R
E
GILLI
A
DE
I
AT
G
FG
RTG
K
LFA
CEHAEIA
PD
I
L
C
L
G
K
A
L
T
GG
T
M
T
L
S
A
TL
T
T
R
EV
A
E
T
IS
N
G
E
AG
CFMH
G
P
T
FM
GNPLA
C
AAA
N
A
S
L
AILESGDWQ
H
QVAAIEA
Q
L
R
E
Q
L
AP
A
C
D
A-EMVA
DVR
V
LG
fig|869729.3.peg.2941
Escherichia coli UM146 (1-344/410)
MTS
P
LP
V
Y
P
V
A
---
--S
AEG
CE
L
I
L
S
D
G
RR
L
VD
GMS
SW
WAAIH
G
Y
N
HP
Q
L
N
AA
M
-
K
S
Q
IDAMS
H
VMFGGITH
A
PA
I
E
L
C
R
K
L
VAMT
P
QPL-EC
V
FLAD
SGS
V
A
V
E
V
A
M
K
M
A
L
QYWQAKGEA
-
R
QRF
L
T
F
R
N
G
YHG
D
T
--------
FG
A
MS
V
CDPDNS
M
HSLWK
G
YL
P
E
N
LFAPAPQSRMDGEWDERDMVGFARLMA-
-
AHRHEI
AA
V
I
I
EP
IV
QG
A
GG
MRMYH
PE
W
L
KR
I
R
K
M
CD
R
E
GILLI
A
DE
I
AT
G
FG
RTG
K
LFA
CEHAEIA
PD
I
L
C
L
G
K
A
L
T
GG
T
M
T
L
S
A
TL
T
T
R
EV
A
E
T
IS
N
G
E
AG
CFMH
G
P
T
FM
GNPLA
C
AAA
N
A
S
L
AILESGDWQ
H
QVAAIEA
Q
L
R
E
Q
L
AP
A
C
D
A-EMVA
DVR
V
LG
fig|364106.7.peg.860
Escherichia coli UTI89 (1-344/410)
MTS
P
LP
V
Y
P
V
A
---
--S
AEG
CE
L
I
L
S
D
G
RR
L
VD
GMS
SW
WAAIH
G
Y
N
HP
Q
L
N
AA
M
-
K
S
Q
IDAMS
H
VMFGGITH
A
PA
I
E
L
C
R
K
L
VAMT
P
QPL-EC
V
FLAD
SGS
V
A
V
E
V
A
M
K
M
A
L
QYWQAKGEA
-
R
QRF
L
T
F
R
N
G
YHG
D
T
--------
FG
A
MS
V
CDPDNS
M
HSLWK
G
YL
P
E
N
LFAPAPQSRMDGEWDERDMVGFARLMA-
-
AHRHEI
AA
V
I
I
EP
IV
QG
A
GG
MRMYH
PE
W
L
KR
I
R
K
M
CD
R
E
GILLI
A
DE
I
AT
G
FG
RTG
K
LFA
CEHAEIA
PD
I
L
C
L
G
K
A
L
T
GG
T
M
T
L
S
A
TL
T
T
R
EV
A
E
T
IS
N
G
E
AG
CFMH
G
P
T
FM
GNPLA
C
AAA
N
A
S
L
AILESGDWQ
H
QVAAIEA
Q
L
R
E
Q
L
AP
A
C
D
A-EMVA
DVR
V
LG
fig|364106.8.peg.859
Escherichia coli UTI89 (1-344/410)
MTS
P
LP
V
Y
P
V
A
---
--S
AEG
CE
L
I
L
S
D
G
RR
L
VD
GMS
SW
WAAIH
G
Y
N
HP
Q
L
N
AA
M
-
K
S
Q
IDAMS
H
VMFGGITH
A
PA
I
E
L
C
R
K
L
VAMT
P
QPL-EC
V
FLAD
SGS
V
A
V
E
V
A
M
K
M
A
L
QYWQAKGEA
-
R
QRF
L
T
F
R
N
G
YHG
D
T
--------
FG
A
MS
V
CDPDNS
M
HSLWK
G
YL
P
E
N
LFAPAPQSRMDGEWDERDMVGFARLMA-
-
AHRHEI
AA
V
I
I
EP
IV
QG
A
GG
MRMYH
PE
W
L
KR
I
R
K
M
CD
R
E
GILLI
A
DE
I
AT
G
FG
RTG
K
LFA
CEHAEIA
PD
I
L
C
L
G
K
A
L
T
GG
T
M
T
L
S
A
TL
T
T
R
EV
A
E
T
IS
N
G
E
AG
CFMH
G
P
T
FM
GNPLA
C
AAA
N
A
S
L
AILESGDWQ
H
QVAAIEA
Q
L
R
E
Q
L
AP
A
C
D
A-EMVA
DVR
V
LG
fig|562.376.peg.4833
Escherichia coli WV_060327 (1-344/410)
MTS
P
LP
V
Y
P
V
A
---
--S
AEG
CE
L
I
L
S
D
G
RR
L
VD
GMS
SW
WAAIH
G
Y
N
HP
Q
L
N
AA
M
-
K
S
Q
IDAMS
H
VMFGGITH
A
PA
I
E
L
C
R
K
L
VAMT
P
QPL-EC
V
FLAD
SGS
V
A
V
E
V
A
M
K
M
A
L
QYWQAKGEA
-
R
QRF
L
T
F
R
N
G
YHG
D
T
--------
FG
A
MS
V
CDPDNS
M
HSLWK
G
YL
P
E
N
LFAPAPQSRMDGEWDERDMVGFARLMA-
-
AHRHEI
AA
V
I
I
EP
IV
QG
A
GG
MRMYH
PE
W
L
KR
I
R
K
M
CD
R
E
GILLI
A
DE
I
AT
G
FG
RTG
K
LFA
CEHAEIA
PD
I
L
C
L
G
K
A
L
T
GG
T
M
T
L
S
A
TL
T
T
R
EV
A
E
T
IS
N
G
E
AG
CFMH
G
P
T
FM
GNPLA
C
AAA
N
A
S
L
AILESGDWQ
H
QVAAIEA
Q
L
R
E
Q
L
AP
A
C
D
A-EMVA
DVR
V
LG
fig|585397.7.peg.745
Escherichia coli ED1a (1-344/410)
MTS
P
LP
V
Y
P
V
A
---
--S
AEG
CE
L
I
L
S
D
G
RR
L
VD
GMS
SW
WAAIH
G
Y
N
HP
Q
L
N
AA
M
-
K
S
Q
IDAMS
H
VMFGGITH
A
PA
I
E
L
C
R
K
L
VAMT
P
QPL-EC
V
FLAD
SGS
V
A
V
E
V
A
M
K
M
A
L
QYWQAKGEA
-
R
QRF
L
T
F
R
N
G
YHG
D
T
--------
FG
A
MS
V
CDPDNS
M
HSLWK
G
YL
P
E
N
LFAPAPQSRMDGEWDERDMVGFARLMA-
-
AHRHEI
AA
V
I
I
EP
IV
QG
A
GG
MRMYH
PE
W
L
KR
I
R
K
M
CD
R
E
GILLI
A
DE
I
AT
G
FG
RTG
K
LFA
CEHAEIA
PD
I
L
C
L
G
K
A
L
T
GG
T
M
T
L
S
A
TL
T
T
R
EV
A
E
T
IS
N
G
E
AG
CFMH
G
P
T
FM
GNPLA
C
AAA
N
A
S
L
AILESGDWQ
H
QVAAIEA
Q
L
R
E
Q
L
AP
A
C
D
A-EMVA
DVR
V
LG
fig|585397.9.peg.745
Escherichia coli ED1a (1-344/410)
MTS
P
LP
V
Y
P
V
A
---
--S
AEG
CE
L
I
L
S
D
G
RR
L
VD
GMS
SW
WAAIH
G
Y
N
HP
Q
L
N
AA
M
-
K
S
Q
IDAMS
H
VMFGGITH
A
PA
I
E
L
C
R
K
L
VAMT
P
QPL-EC
V
FLAD
SGS
V
A
V
E
V
A
M
K
M
A
L
QYWQAKGEA
-
R
QRF
L
T
F
R
N
G
YHG
D
T
--------
FG
A
MS
V
CDPDNS
M
HSLWK
G
YL
P
E
N
LFAPAPQSRMDGEWDERDMVGFARLMA-
-
AHRHEI
AA
V
I
I
EP
IV
QG
A
GG
MRMYH
PE
W
L
KR
I
R
K
M
CD
R
E
GILLI
A
DE
I
AT
G
FG
RTG
K
LFA
CEHAEIA
PD
I
L
C
L
G
K
A
L
T
GG
T
M
T
L
S
A
TL
T
T
R
EV
A
E
T
IS
N
G
E
AG
CFMH
G
P
T
FM
GNPLA
C
AAA
N
A
S
L
AILESGDWQ
H
QVAAIEA
Q
L
R
E
Q
L
AP
A
C
D
A-EMVA
DVR
V
LG
fig|405955.9.peg.612
Escherichia coli APEC O1 (26-369/435)
MTS
P
LP
V
Y
P
V
A
---
--S
AEG
CE
L
I
L
S
D
G
RR
L
VD
GMS
SW
WAAIH
G
Y
N
HP
Q
L
N
AA
M
-
K
S
Q
IDAMS
H
VMFGGITH
A
PA
I
E
L
C
R
K
L
VAMT
P
QPL-EC
V
FLAD
SGS
V
A
V
E
V
A
M
K
M
A
L
QYWQAKGEA
-
R
QRF
L
T
F
R
N
G
YHG
D
T
--------
FG
A
MS
V
CDPDNS
M
HSLWK
G
YL
P
E
N
LFAPAPQSRMDGEWDERDMVGFARLMA-
-
AHRHEI
AA
V
I
I
EP
IV
QG
A
GG
MRMYH
PE
W
L
KR
I
R
K
M
CD
R
E
GILLI
A
DE
I
AT
G
FG
RTG
K
LFA
CEHAEIA
PD
I
L
C
L
G
K
A
L
T
GG
T
M
T
L
S
A
TL
T
T
R
EV
A
E
T
IS
N
G
E
AG
CFMH
G
P
T
FM
GNPLA
C
AAA
N
A
S
L
AILESGDWQ
H
QVAAIEA
Q
L
R
E
Q
L
AP
A
C
D
A-EMVA
DVR
V
LG
fig|199310.1.peg.826
Escherichia coli CFT073 (57-400/466)
MTS
P
LP
V
Y
P
V
A
---
--S
AEG
CE
L
I
L
S
D
G
RR
L
VD
GMS
SW
WAAIH
G
Y
N
HP
Q
L
N
AA
M
-
K
S
Q
IDAMS
H
VMFGGITH
A
PA
I
E
L
C
R
K
L
VAMT
P
QPL-EC
V
FLAD
SGS
V
A
V
E
V
A
M
K
M
A
L
QYWQAKGEA
-
R
QRF
L
T
F
R
N
G
YHG
D
T
--------
FG
A
MS
V
CDPDNS
M
HSLWK
G
YL
P
E
N
LFAPAPQSRMDGEWDERDMVGFARLMA-
-
AHRHEI
AA
V
I
I
EP
IV
QG
A
GG
MRMYH
PE
W
L
KR
I
R
K
M
CD
R
E
GILLI
A
DE
I
AT
G
FG
RTG
K
LFA
CEHAEIA
PD
I
L
C
L
G
K
A
L
T
GG
T
M
T
L
S
A
TL
T
T
R
EV
A
E
T
IS
N
G
E
AG
CFMH
G
P
T
FM
GNPLA
C
AAA
N
A
S
L
AILESGDWQ
H
QVAAIEA
Q
L
R
E
Q
L
AP
A
C
D
A-EMVA
DVR
V
LG
fig|585057.4.peg.796
Escherichia coli IAI39 (1-344/410)
MTS
P
LP
V
Y
P
V
A
---
--S
AEG
CE
L
I
L
S
D
G
RR
L
VD
GMS
SW
WAAIH
G
Y
N
HP
Q
L
N
AA
M
-
K
S
Q
IDAMS
H
VMFGGITH
A
PA
I
E
L
C
R
K
L
VAMT
P
QPL-EC
V
FLAD
SGS
V
A
V
E
V
A
M
K
M
A
L
QYWQAKGEA
-
R
QRF
L
T
F
R
N
G
YHG
D
T
--------
FG
A
MS
V
CDPDNS
M
HSLWK
G
YL
P
E
N
LFAPAPQSRLDGEWDERDMVGFARLMA-
-
AHRHEI
AA
V
I
I
EP
IV
QG
A
GG
MRMYH
PE
W
L
KR
I
R
K
M
CD
R
E
GILLI
A
DE
I
AT
G
FG
RTG
K
LFA
CEHAEIA
PD
I
L
C
L
G
K
A
L
T
GG
T
M
T
L
S
A
TL
T
T
R
EV
A
E
T
IS
N
G
E
AG
CFMH
G
P
T
FM
GNPLA
C
AAA
N
A
S
L
AILESGDWQ
Q
QVAAIEV
Q
L
R
E
Q
L
AP
A
C
G
A-EMVA
DVR
V
LG
fig|585057.6.peg.793
Escherichia coli IAI39 (1-344/410)
MTS
P
LP
V
Y
P
V
A
---
--S
AEG
CE
L
I
L
S
D
G
RR
L
VD
GMS
SW
WAAIH
G
Y
N
HP
Q
L
N
AA
M
-
K
S
Q
IDAMS
H
VMFGGITH
A
PA
I
E
L
C
R
K
L
VAMT
P
QPL-EC
V
FLAD
SGS
V
A
V
E
V
A
M
K
M
A
L
QYWQAKGEA
-
R
QRF
L
T
F
R
N
G
YHG
D
T
--------
FG
A
MS
V
CDPDNS
M
HSLWK
G
YL
P
E
N
LFAPAPQSRLDGEWDERDMVGFARLMA-
-
AHRHEI
AA
V
I
I
EP
IV
QG
A
GG
MRMYH
PE
W
L
KR
I
R
K
M
CD
R
E
GILLI
A
DE
I
AT
G
FG
RTG
K
LFA
CEHAEIA
PD
I
L
C
L
G
K
A
L
T
GG
T
M
T
L
S
A
TL
T
T
R
EV
A
E
T
IS
N
G
E
AG
CFMH
G
P
T
FM
GNPLA
C
AAA
N
A
S
L
AILESGDWQ
Q
QVAAIEV
Q
L
R
E
Q
L
AP
A
C
G
A-EMVA
DVR
V
LG
fig|679205.4.peg.2600
Escherichia coli MS 124-1 (1-344/410)
MTS
P
LP
V
Y
P
V
V
---
--S
AEG
CE
L
I
L
S
D
G
KR
L
VD
GMS
SW
WAAIH
G
Y
N
HP
Q
L
N
AA
M
-
K
S
Q
IDAMS
H
VMFGGITH
A
PA
I
E
L
C
R
K
L
VAMT
P
QPL-EC
V
FLAD
SGS
V
A
V
E
V
A
M
K
M
A
L
QYWQAKGEA
-
R
QRF
L
T
F
R
N
G
YHG
D
T
--------
FG
A
MS
V
CDPDNS
M
HSLWK
G
YL
P
E
N
LFAPAPQSRMDGEWDERDMVGFARLMA-
-
AHRHEI
AA
V
I
I
EP
IV
QG
A
GG
MRMYH
PE
W
L
KR
I
R
K
M
CD
R
E
GILLI
A
DE
I
AT
G
FG
RTG
K
LFA
CEYAEIA
PD
I
L
C
L
G
K
A
L
T
GG
T
M
T
L
S
A
TL
T
T
R
EV
A
E
T
IS
N
G
E
AG
CFMH
G
P
T
FM
GNPLA
C
AAA
N
A
S
L
AIIESGEWQ
Q
QVAAIEV
Q
L
R
E
Q
L
AP
A
R
D
A-EMVA
DVR
V
LG
fig|749533.3.peg.4785
Escherichia coli MS 84-1 (1-344/410)
MTS
P
LP
V
Y
P
V
V
---
--S
AEG
CE
L
I
L
S
D
G
KR
L
VD
GMS
SW
WAAIH
G
Y
N
HP
Q
L
N
AA
M
-
K
S
Q
IDAMS
H
VMFGGITH
A
PA
I
E
L
C
R
K
L
VAMT
P
QPL-EC
V
FLAD
SGS
V
A
V
E
V
A
M
K
M
A
L
QYWQAKGEA
-
R
QRF
L
T
F
R
N
G
YHG
D
T
--------
FG
A
MS
V
CDPDNS
M
HSLWK
G
YL
P
E
N
LFAPAPQSRMDGEWDERDMVGFARLMA-
-
AHRHEI
AA
V
I
I
EP
IV
QG
A
GG
MRMYH
PE
W
L
KR
I
R
K
M
CD
R
E
GILLI
A
DE
I
AT
G
FG
RTG
K
LFA
CEYAEIA
PD
I
L
C
L
G
K
A
L
T
GG
T
M
T
L
S
A
TL
T
T
R
EV
A
E
T
IS
N
G
E
AG
CFMH
G
P
T
FM
GNPLA
C
AAA
N
A
S
L
AIIESGEWQ
Q
QVAAIEV
Q
L
R
E
Q
L
AP
A
R
D
A-EMVA
DVR
V
LG
fig|331111.12.peg.1132
Escherichia coli E24377A (1-344/410)
MTS
P
LP
V
Y
P
V
A
---
--S
AEG
CE
L
I
L
S
D
G
RR
L
VD
GMS
SW
WAAIH
G
Y
N
HP
Q
L
N
AA
M
-
K
S
Q
IDAMS
H
VMFGGITH
T
PA
I
E
L
C
R
K
L
VAMT
P
QPL-EC
V
FLAD
SGS
V
A
V
E
V
A
M
K
M
A
L
QYWQAKGEA
-
R
QRF
L
T
F
R
N
G
YHG
D
T
--------
FG
A
MS
V
CDPDNS
M
HSLWK
G
YL
P
E
N
LFAPAPQSRMDGEWDERDMVGFARLMA-
-
AHRHEI
AA
V
I
I
EP
IV
QG
A
GG
MRMYH
PE
W
L
KR
I
R
K
M
CD
R
E
GILLI
A
DE
I
AT
G
FG
RTG
K
LFA
CEYAEIA
PD
I
L
C
L
G
K
A
L
T
GG
T
M
T
L
S
A
TL
T
T
R
EV
A
E
T
IS
N
G
E
AG
CFMH
G
P
T
FM
GNPLA
C
AAA
N
A
S
L
AILESGDWQ
Q
QVADIEV
Q
L
R
E
Q
L
AP
A
R
N
A-EMVA
DVR
V
LG
fig|562.375.peg.4363
Escherichia coli EC4100B (1-344/410)
MTS
P
LP
V
Y
P
V
A
---
--S
AEG
CE
L
I
L
S
D
G
RR
L
VD
GMS
SW
WAAIH
G
Y
N
HP
Q
L
N
AA
M
-
K
S
Q
IDAMS
H
VMFGGITH
T
PA
I
E
L
C
R
K
L
VAMT
P
QPL-EC
V
FLAD
SGS
V
A
V
E
V
A
M
K
M
A
L
QYWQAKGEA
-
R
QRF
L
T
F
R
N
G
YHG
D
T
--------
FG
A
MS
V
CDPDNS
M
HSLWK
G
YL
P
E
N
LFAPAPQSRMDGEWDERDMVGFARLMA-
-
AHRHEI
AA
V
I
I
EP
IV
QG
A
GG
MRMYH
PE
W
L
KR
I
R
K
M
CD
R
E
GILLI
A
DE
I
AT
G
FG
RTG
K
LFA
CEYAEIA
PD
I
L
C
L
G
K
A
L
T
GG
T
M
T
L
S
A
TL
T
T
R
EV
A
E
T
IS
N
G
E
AG
CFMH
G
P
T
FM
GNPLA
C
AAA
N
A
S
L
AILESGDWQ
Q
QVADIEV
Q
L
R
E
Q
L
AP
A
R
N
A-EMVA
DVR
V
LG
fig|585034.4.peg.795
Escherichia coli IAI1 (1-344/410)
MTS
P
LP
V
Y
P
V
A
---
--S
AEG
CE
L
I
L
S
D
G
RR
L
VD
GMS
SW
WAAIH
G
Y
N
HP
Q
L
N
AA
M
-
K
S
Q
IDAMS
H
VMFGGITH
T
PA
I
E
L
C
R
K
L
VAMT
P
QPL-EC
V
FLAD
SGS
V
A
V
E
V
A
M
K
M
A
L
QYWQAKGEA
-
R
QRF
L
T
F
R
N
G
YHG
D
T
--------
FG
A
MS
V
CDPDNS
M
HSLWK
G
YL
P
E
N
LFAPAPQSRMDGEWDERDMVGFARLMA-
-
AHRHEI
AA
V
I
I
EP
IV
QG
A
GG
MRMYH
PE
W
L
KR
I
R
K
M
CD
R
E
GILLI
A
DE
I
AT
G
FG
RTG
K
LFA
CEYAEIA
PD
I
L
C
L
G
K
A
L
T
GG
T
M
T
L
S
A
TL
T
T
R
EV
A
E
T
IS
N
G
E
AG
CFMH
G
P
T
FM
GNPLA
C
AAA
N
A
S
L
AILESGDWQ
Q
QVADIEV
Q
L
R
E
Q
L
AP
A
R
N
A-EMVA
DVR
V
LG
fig|585034.5.peg.792
Escherichia coli IAI1 (1-344/410)
MTS
P
LP
V
Y
P
V
A
---
--S
AEG
CE
L
I
L
S
D
G
RR
L
VD
GMS
SW
WAAIH
G
Y
N
HP
Q
L
N
AA
M
-
K
S
Q
IDAMS
H
VMFGGITH
T
PA
I
E
L
C
R
K
L
VAMT
P
QPL-EC
V
FLAD
SGS
V
A
V
E
V
A
M
K
M
A
L
QYWQAKGEA
-
R
QRF
L
T
F
R
N
G
YHG
D
T
--------
FG
A
MS
V
CDPDNS
M
HSLWK
G
YL
P
E
N
LFAPAPQSRMDGEWDERDMVGFARLMA-
-
AHRHEI
AA
V
I
I
EP
IV
QG
A
GG
MRMYH
PE
W
L
KR
I
R
K
M
CD
R
E
GILLI
A
DE
I
AT
G
FG
RTG
K
LFA
CEYAEIA
PD
I
L
C
L
G
K
A
L
T
GG
T
M
T
L
S
A
TL
T
T
R
EV
A
E
T
IS
N
G
E
AG
CFMH
G
P
T
FM
GNPLA
C
AAA
N
A
S
L
AILESGDWQ
Q
QVADIEV
Q
L
R
E
Q
L
AP
A
R
N
A-EMVA
DVR
V
LG
fig|679207.4.peg.1429
Escherichia coli MS 107-1 (1-344/410)
MTS
P
LP
V
Y
P
V
A
---
--S
AEG
CE
L
I
L
S
D
G
RR
L
VD
GMS
SW
WAAIH
G
Y
N
HP
Q
L
N
AA
M
-
K
S
Q
IDAMS
H
VMFGGITH
T
PA
I
E
L
C
R
K
L
VAMT
P
QPL-EC
V
FLAD
SGS
V
A
V
E
V
A
M
K
M
A
L
QYWQAKGEA
-
R
QRF
L
T
F
R
N
G
YHG
D
T
--------
FG
A
MS
V
CDPDNS
M
HSLWK
G
YL
P
E
N
LFAPAPQSRMDGEWDERDMVGFARLMA-
-
AHRHEI
AA
V
I
I
EP
IV
QG
A
GG
MRMYH
PE
W
L
KR
I
R
K
M
CD
R
E
GILLI
A
DE
I
AT
G
FG
RTG
K
LFA
CEYAEIA
PD
I
L
C
L
G
K
A
L
T
GG
T
M
T
L
S
A
TL
T
T
R
EV
A
E
T
IS
N
G
E
AG
CFMH
G
P
T
FM
GNPLA
C
AAA
N
A
S
L
AILESGDWQ
Q
QVADIEV
Q
L
R
E
Q
L
AP
A
R
N
A-EMVA
DVR
V
LG
fig|749545.3.peg.967
Escherichia coli MS 182-1 (1-344/410)
MTS
P
LP
V
Y
P
V
A
---
--S
AEG
CE
L
I
L
S
D
G
RR
L
VD
GMS
SW
WAAIH
G
Y
N
HP
Q
L
N
AA
M
-
K
S
Q
IDAMS
H
VMFGGITH
T
PA
I
E
L
C
R
K
L
VAMT
P
QPL-EC
V
FLAD
SGS
V
A
V
E
V
A
M
K
M
A
L
QYWQAKGEA
-
R
QRF
L
T
F
R
N
G
YHG
D
T
--------
FG
A
MS
V
CDPDNS
M
HSLWK
G
YL
P
E
N
LFAPAPQSRMDGEWDERDMVGFARLMA-
-
AHRHEI
AA
V
I
I
EP
IV
QG
A
GG
MRMYH
PE
W
L
KR
I
R
K
M
CD
R
E
GILLI
A
DE
I
AT
G
FG
RTG
K
LFA
CEYAEIA
PD
I
L
C
L
G
K
A
L
T
GG
T
M
T
L
S
A
TL
T
T
R
EV
A
E
T
IS
N
G
E
AG
CFMH
G
P
T
FM
GNPLA
C
AAA
N
A
S
L
AILESGDWQ
Q
QVADIEV
Q
L
R
E
Q
L
AP
A
R
N
A-EMVA
DVR
V
LG
fig|749532.3.peg.2646
Escherichia coli MS 78-1 (1-344/410)
MTS
P
LP
V
Y
P
V
A
---
--S
AEG
CE
L
I
L
S
D
G
RR
L
VD
GMS
SW
WAAIH
G
Y
N
HP
Q
L
N
AA
M
-
K
S
Q
IDAMS
H
VMFGGITH
T
PA
I
E
L
C
R
K
L
VAMT
P
QPL-EC
V
FLAD
SGS
V
A
V
E
V
A
M
K
M
A
L
QYWQAKGEA
-
R
QRF
L
T
F
R
N
G
YHG
D
T
--------
FG
A
MS
V
CDPDNS
M
HSLWK
G
YL
P
E
N
LFAPAPQSRMDGEWDERDMVGFARLMA-
-
AHRHEI
AA
V
I
I
EP
IV
QG
A
GG
MRMYH
PE
W
L
KR
I
R
K
M
CD
R
E
GILLI
A
DE
I
AT
G
FG
RTG
K
LFA
CEYAEIA
PD
I
L
C
L
G
K
A
L
T
GG
T
M
T
L
S
A
TL
T
T
R
EV
A
E
T
IS
N
G
E
AG
CFMH
G
P
T
FM
GNPLA
C
AAA
N
A
S
L
AILESGDWQ
Q
QVADIEV
Q
L
R
E
Q
L
AP
A
R
N
A-EMVA
DVR
V
LG
fig|409438.11.peg.954
Escherichia coli SE11 (1-344/410)
MTS
P
LP
V
Y
P
V
A
---
--S
AEG
CE
L
I
L
S
D
G
RR
L
VD
GMS
SW
WAAIH
G
Y
N
HP
Q
L
N
AA
M
-
K
S
Q
IDAMS
H
VMFGGITH
T
PA
I
E
L
C
R
K
L
VAMT
P
QPL-EC
V
FLAD
SGS
V
A
V
E
V
A
M
K
M
A
L
QYWQAKGEA
-
R
QRF
L
T
F
R
N
G
YHG
D
T
--------
FG
A
MS
V
CDPDNS
M
HSLWK
G
YL
P
E
N
LFAPAPQSRMDGEWDERDMVGFARLMA-
-
AHRHEI
AA
V
I
I
EP
IV
QG
A
GG
MRMYH
PE
W
L
KR
I
R
K
M
CD
R
E
GILLI
A
DE
I
AT
G
FG
RTG
K
LFA
CEYAEIA
PD
I
L
C
L
G
K
A
L
T
GG
T
M
T
L
S
A
TL
T
T
R
EV
A
E
T
IS
N
G
E
AG
CFMH
G
P
T
FM
GNPLA
C
AAA
N
A
S
L
AILESGDWQ
Q
QVADIEV
Q
L
R
E
Q
L
AP
A
R
N
A-EMVA
DVR
V
LG
fig|331111.3.peg.3340
Escherichia coli E24377A (57-400/466)
MTS
P
LP
V
Y
P
V
A
---
--S
AEG
CE
L
I
L
S
D
G
RR
L
VD
GMS
SW
WAAIH
G
Y
N
HP
Q
L
N
AA
M
-
K
S
Q
IDAMS
H
VMFGGITH
T
PA
I
E
L
C
R
K
L
VAMT
P
QPL-EC
V
FLAD
SGS
V
A
V
E
V
A
M
K
M
A
L
QYWQAKGEA
-
R
QRF
L
T
F
R
N
G
YHG
D
T
--------
FG
A
MS
V
CDPDNS
M
HSLWK
G
YL
P
E
N
LFAPAPQSRMDGEWDERDMVGFARLMA-
-
AHRHEI
AA
V
I
I
EP
IV
QG
A
GG
MRMYH
PE
W
L
KR
I
R
K
M
CD
R
E
GILLI
A
DE
I
AT
G
FG
RTG
K
LFA
CEYAEIA
PD
I
L
C
L
G
K
A
L
T
GG
T
M
T
L
S
A
TL
T
T
R
EV
A
E
T
IS
N
G
E
AG
CFMH
G
P
T
FM
GNPLA
C
AAA
N
A
S
L
AILESGDWQ
Q
QVADIEV
Q
L
R
E
Q
L
AP
A
R
N
A-EMVA
DVR
V
LG
fig|431946.3.peg.733
Escherichia coli SE15 (1-344/410)
MTS
P
LP
V
Y
P
V
A
---
--S
AEG
CE
L
I
L
S
D
G
RR
L
VD
GMS
SW
WAAIH
G
Y
N
HP
Q
L
N
AA
M
-
K
S
Q
IDAMS
H
VMFGGITH
A
PA
I
E
L
C
R
K
L
VAMT
P
QPL-EC
V
FLAD
SGS
V
A
V
E
V
A
M
K
M
A
L
QYWQAKGEA
-
R
QRF
L
T
F
R
N
G
YHG
D
T
--------
FG
A
MS
V
CDPDNS
M
HNLWK
G
YL
P
E
N
LFAPAPQSRMDGEWDERDMVGFARLMA-
-
AHRHEI
AA
V
I
I
EP
IV
QG
A
GG
MRMYH
PE
W
L
KR
I
R
K
M
CD
R
E
GILLI
A
DE
I
AT
G
FG
RTG
K
LFA
CEHAEIA
PD
I
L
C
L
G
K
A
L
T
GG
T
M
T
L
S
A
TL
T
T
R
EV
A
E
T
IS
N
G
E
AG
CFMH
G
P
T
FM
GNPLA
C
AAA
N
A
S
L
AILESGDWQ
H
QVAAIEA
Q
L
R
E
Q
L
AP
A
C
D
A-EMVA
DVR
V
LG
fig|656444.3.peg.1321
Escherichia coli TA280 (1-344/410)
MTS
P
LP
V
Y
P
V
A
---
--S
AEG
CE
L
I
L
S
D
G
RR
L
VD
GMS
SW
WAAIH
G
Y
N
HP
Q
L
N
AA
M
-
K
S
Q
IDAMS
H
VMFGGITH
A
PA
I
E
L
C
R
K
L
VAMT
P
QPL-EC
V
FLAD
SGS
V
A
V
E
V
A
M
K
M
A
L
QYWQAKGEA
-
R
QRF
L
T
F
R
N
G
YHG
D
T
--------
FG
A
MS
V
CDPDNS
M
HSLWK
G
YL
P
E
N
LFAPAPQSRMDGEWDERDMVGFARLMA-
-
AHRHEI
AA
V
I
I
EP
IV
QG
A
GG
MRMYH
PE
W
L
KR
I
R
K
M
CD
R
E
GILLI
A
DE
I
AT
G
FG
RTG
K
LFA
CEHADIA
PD
I
L
C
L
G
K
A
L
T
GG
T
M
T
L
S
A
TL
T
T
R
EV
A
E
T
IS
N
G
E
AG
CFMH
G
P
T
FM
GNPLA
C
AAA
N
A
S
L
AILESGDWQ
H
QVAAIEA
Q
L
R
E
Q
L
AP
A
C
D
A-EMVA
DVR
V
LG
fig|656393.3.peg.1525
Escherichia coli H299 (1-344/410)
MTS
P
LP
V
Y
P
V
A
---
--S
AEG
CE
L
I
L
S
D
G
RR
L
VD
GMS
SW
WAAIH
G
Y
N
HP
Q
L
N
AA
M
-
K
S
Q
IDAMS
H
VMFGGITH
A
PA
I
E
L
C
R
K
L
VAMT
P
QPL-EC
V
FLAD
SGS
V
A
V
E
V
A
M
K
M
A
L
QYWQAKGEA
-
R
QRF
L
T
F
R
N
G
YHG
D
T
--------
FG
A
MS
V
CDPDNS
M
HSLWK
G
YL
P
E
N
LFAPAPQSRMDGEWDERNMVGFARLMA-
-
AHRHEI
AA
V
I
I
EP
IV
QG
A
GG
MRMYH
PE
W
L
KR
I
R
K
M
CD
R
E
GILLI
A
DE
I
AT
G
FG
RTG
K
LFA
CEHAEIA
PD
I
L
C
L
G
K
A
L
T
GG
T
M
T
L
S
A
TL
T
T
R
EV
A
E
T
IS
N
G
E
AG
CFMH
G
P
T
FM
GNPLA
C
AAA
N
A
S
L
AILESGDWQ
H
QVAAIEA
Q
L
R
E
Q
L
AP
A
C
D
A-EMVA
DVR
V
LG
fig|749527.3.peg.4342
Escherichia coli MS 21-1 (1-344/410)
MTS
P
LP
V
Y
P
V
A
---
--S
AEG
CE
L
I
L
S
D
G
RR
L
VD
GMS
SW
WAAIH
G
Y
N
HP
Q
L
N
AA
M
-
K
S
Q
IDAMS
H
VMFGGITH
A
PA
I
E
L
C
R
K
L
VAMT
P
QPL-EC
V
FLAD
SGS
V
A
V
E
V
A
M
K
M
A
L
QYWQAKGEA
-
R
QRF
L
T
F
R
N
G
YHG
D
T
--------
FG
A
MS
V
CDPDNS
M
HSLWK
G
YL
P
E
N
LFAPAPQSRLDGEWDERDMVGFARLMA-
-
AHRHEI
AA
V
I
I
EP
IV
QG
A
GG
MRMYH
PE
W
L
KR
I
R
K
M
CD
R
E
GILLI
A
DE
I
AT
G
FG
RTG
K
LFA
CEHAEIA
PD
I
L
C
L
G
K
A
L
T
GG
T
M
T
L
S
A
TL
T
T
R
EV
A
E
T
IS
N
G
E
AG
CFMH
G
P
T
FM
GNPLA
C
AAA
N
A
S
L
AILESGDWQ
H
QVAAIEG
Q
L
R
E
Q
L
AP
A
C
D
A-EMVA
DVR
V
LG
fig|362663.8.peg.793
Escherichia coli 536 (1-344/410)
MTS
P
LP
V
Y
P
V
A
---
--S
AEG
CE
L
I
L
S
D
G
RR
L
VD
GMS
SW
WAAIH
G
Y
N
HP
Q
L
N
AA
M
-
K
S
Q
IDAMS
H
VMFGGITH
A
PA
I
E
L
C
R
K
L
VAMT
P
QPL-EC
V
FLAD
SGS
V
A
V
E
V
A
M
K
M
A
L
QYWQAKGEA
-
R
QRF
L
T
F
R
N
G
YHG
D
T
--------
FG
A
MS
V
CDPDNS
M
HSLWK
G
YL
P
E
N
LFAPAPQSRMDGEWDERDMVGFARLMA-
-
AHRHEI
AA
V
I
I
EP
IV
QG
A
GG
MRMYH
PE
W
L
KR
I
R
K
M
CD
R
E
GILLI
A
DE
I
AT
G
FG
RTG
K
LFA
CEHAEIA
PD
I
L
C
L
G
K
A
L
T
GG
T
M
T
L
S
A
TL
T
T
R
EV
A
E
T
IS
N
G
E
AG
CFMH
G
P
T
FM
GNPLA
C
AAA
N
A
S
L
AILESGDWQ
H
QVAAIEG
Q
L
R
E
Q
L
AP
T
C
D
A-EMVA
DVR
V
LG
fig|362663.9.peg.793
Escherichia coli 536 (1-344/410)
MTS
P
LP
V
Y
P
V
A
---
--S
AEG
CE
L
I
L
S
D
G
RR
L
VD
GMS
SW
WAAIH
G
Y
N
HP
Q
L
N
AA
M
-
K
S
Q
IDAMS
H
VMFGGITH
A
PA
I
E
L
C
R
K
L
VAMT
P
QPL-EC
V
FLAD
SGS
V
A
V
E
V
A
M
K
M
A
L
QYWQAKGEA
-
R
QRF
L
T
F
R
N
G
YHG
D
T
--------
FG
A
MS
V
CDPDNS
M
HSLWK
G
YL
P
E
N
LFAPAPQSRMDGEWDERDMVGFARLMA-
-
AHRHEI
AA
V
I
I
EP
IV
QG
A
GG
MRMYH
PE
W
L
KR
I
R
K
M
CD
R
E
GILLI
A
DE
I
AT
G
FG
RTG
K
LFA
CEHAEIA
PD
I
L
C
L
G
K
A
L
T
GG
T
M
T
L
S
A
TL
T
T
R
EV
A
E
T
IS
N
G
E
AG
CFMH
G
P
T
FM
GNPLA
C
AAA
N
A
S
L
AILESGDWQ
H
QVAAIEG
Q
L
R
E
Q
L
AP
T
C
D
A-EMVA
DVR
V
LG
fig|550677.3.peg.2041
Escherichia coli B354 (1-344/410)
MTS
P
LP
V
Y
P
V
A
---
--S
AEG
CE
L
I
L
S
D
G
RC
L
VD
GMS
SW
WAAIH
G
Y
N
HP
Q
L
N
AA
M
-
K
S
Q
IDAMS
H
VMFGGITH
A
PA
I
E
L
C
R
K
L
VAMT
P
QPL-EC
V
FLAD
SGS
V
A
V
E
V
A
M
K
M
A
L
QYWQAKGEA
-
R
QRF
L
T
F
R
N
G
YHG
D
T
--------
FG
A
MS
V
CDPDNS
M
HSLWK
G
YL
P
E
N
LFAPAPQSRMDGEWDERDMVGFARLMA-
-
AHRHEI
AA
V
I
I
EP
I
A
QG
A
GG
MRIYH
PE
W
L
KR
I
R
K
M
CD
R
E
GILLI
V
DE
I
AT
G
FG
RTG
K
LFA
CEHADIA
PD
I
L
C
L
G
K
A
L
T
GG
T
M
T
L
S
A
TL
T
T
R
EV
A
E
T
IS
N
G
E
AG
CFMH
G
P
T
FM
GNPLA
C
AAA
N
A
S
L
AILESGDWQ
Q
QVAAIEV
Q
L
R
E
Q
L
AP
A
R
D
A-EMVA
DVR
V
LG
fig|670897.3.peg.3491
Escherichia coli 2362-75 (1-344/410)
MTS
P
LP
V
Y
P
V
A
---
--S
AEG
CE
L
I
M
S
D
G
RR
L
VD
GMS
SW
WAAIH
G
Y
N
HP
Q
L
N
AA
M
-
K
S
Q
IDAMS
H
VMFGGITH
A
PA
I
E
L
C
R
K
L
VAMT
P
QPL-EC
V
FLAD
SGS
V
A
V
E
V
A
M
K
M
A
L
QYWQAKGEA
-
R
QRF
L
T
F
R
N
G
YHG
D
T
--------
FG
A
MS
V
CDPDNS
M
HNLWK
G
YL
P
E
N
LFAPAPQSRMDGEWDERDMVGFARLMA-
-
AHRHEI
AA
V
I
I
EP
IV
QG
A
GG
MRMYH
PE
W
L
KR
I
R
K
M
CD
R
E
GILLI
A
DE
I
AT
G
FG
RTG
K
LFA
CEHAEIA
PD
I
L
C
L
G
K
A
L
T
GG
T
M
T
L
S
A
TL
T
T
R
EV
A
E
T
IS
N
G
E
AG
CFMH
G
P
T
FM
GNPLA
C
AAA
N
A
S
L
AILESGDWQ
H
QVAAIEG
Q
L
R
E
Q
L
AP
A
C
D
A-EMVA
DVR
V
LG
fig|574521.7.peg.746
Escherichia coli O127:H6 str. E2348/69 (1-344/410)
MTS
P
LP
V
Y
P
V
A
---
--S
AEG
CE
L
I
M
S
D
G
RR
L
VD
GMS
SW
WAAIH
G
Y
N
HP
Q
L
N
AA
M
-
K
S
Q
IDAMS
H
VMFGGITH
A
PA
I
E
L
C
R
K
L
VAMT
P
QPL-EC
V
FLAD
SGS
V
A
V
E
V
A
M
K
M
A
L
QYWQAKGEA
-
R
QRF
L
T
F
R
N
G
YHG
D
T
--------
FG
A
MS
V
CDPDNS
M
HNLWK
G
YL
P
E
N
LFAPAPQSRMDGEWDERDMVGFARLMA-
-
AHRHEI
AA
V
I
I
EP
IV
QG
A
GG
MRMYH
PE
W
L
KR
I
R
K
M
CD
R
E
GILLI
A
DE
I
AT
G
FG
RTG
K
LFA
CEHAEIA
PD
I
L
C
L
G
K
A
L
T
GG
T
M
T
L
S
A
TL
T
T
R
EV
A
E
T
IS
N
G
E
AG
CFMH
G
P
T
FM
GNPLA
C
AAA
N
A
S
L
AILESGDWQ
H
QVAAIEG
Q
L
R
E
Q
L
AP
A
C
D
A-EMVA
DVR
V
LG
fig|216593.1.peg.1364
Escherichia coli E2348/69 (57-400/466)
MTS
P
LP
V
Y
P
V
A
---
--S
AEG
CE
L
I
M
S
D
G
RR
L
VD
GMS
SW
WAAIH
G
Y
N
HP
Q
L
N
AA
M
-
K
S
Q
IDAMS
H
VMFGGITH
A
PA
I
E
L
C
R
K
L
VAMT
P
QPL-EC
V
FLAD
SGS
V
A
V
E
V
A
M
K
M
A
L
QYWQAKGEA
-
R
QRF
L
T
F
R
N
G
YHG
D
T
--------
FG
A
MS
V
CDPDNS
M
HNLWK
G
YL
P
E
N
LFAPAPQSRMDGEWDERDMVGFARLMA-
-
AHRHEI
AA
V
I
I
EP
IV
QG
A
GG
MRMYH
PE
W
L
KR
I
R
K
M
CD
R
E
GILLI
A
DE
I
AT
G
FG
RTG
K
LFA
CEHAEIA
PD
I
L
C
L
G
K
A
L
T
GG
T
M
T
L
S
A
TL
T
T
R
EV
A
E
T
IS
N
G
E
AG
CFMH
G
P
T
FM
GNPLA
C
AAA
N
A
S
L
AILESGDWQ
H
QVAAIEG
Q
L
R
E
Q
L
AP
A
C
D
A-EMVA
DVR
V
LG
fig|340186.5.peg.2911
Escherichia coli E110019 (1-344/410)
MTS
P
LP
V
Y
P
V
A
---
--S
AEG
CE
L
I
L
S
D
G
RR
L
VD
GMS
SW
WAAIH
G
Y
N
HP
Q
L
N
AA
X
-
K
S
Q
IDAMS
H
VMFGGITH
T
PA
I
E
L
C
R
K
L
VAMT
P
QPL-EC
V
FLAD
SGS
V
A
V
E
V
A
M
K
M
A
L
QYWQAKGEA
-
R
QRF
L
T
F
R
N
G
YHG
D
T
--------
FG
A
MS
V
CDPDNS
M
HSLWK
G
YL
P
E
N
LFAPAPQSRMDGEWDERDMVGFARLMA-
-
AHRHEI
AA
V
I
I
EP
IV
QG
A
GG
MRMYH
PE
W
L
KR
I
R
K
M
CD
R
E
GILLI
A
DE
I
AT
G
FG
RTG
K
LFA
CEYAEIA
PD
I
L
C
L
G
K
A
L
T
GG
T
M
T
L
S
A
TL
T
T
R
EV
A
E
T
IS
N
G
E
AG
CFMH
G
P
T
FM
GNPLA
C
AAA
N
A
S
L
AILESGDWQ
Q
QVADIEV
Q
L
R
E
Q
L
AP
A
R
N
A-EMVA
DVR
V
LG
fig|340186.3.peg.2801
Escherichia coli E110019 (57-400/466)
MTS
P
LP
V
Y
P
V
A
---
--S
AEG
CE
L
I
L
S
D
G
RR
L
VD
GMS
SW
WAAIH
G
Y
N
HP
Q
L
N
AA
X
-
K
S
Q
IDAMS
H
VMFGGITH
T
PA
I
E
L
C
R
K
L
VAMT
P
QPL-EC
V
FLAD
SGS
V
A
V
E
V
A
M
K
M
A
L
QYWQAKGEA
-
R
QRF
L
T
F
R
N
G
YHG
D
T
--------
FG
A
MS
V
CDPDNS
M
HSLWK
G
YL
P
E
N
LFAPAPQSRMDGEWDERDMVGFARLMA-
-
AHRHEI
AA
V
I
I
EP
IV
QG
A
GG
MRMYH
PE
W
L
KR
I
R
K
M
CD
R
E
GILLI
A
DE
I
AT
G
FG
RTG
K
LFA
CEYAEIA
PD
I
L
C
L
G
K
A
L
T
GG
T
M
T
L
S
A
TL
T
T
R
EV
A
E
T
IS
N
G
E
AG
CFMH
G
P
T
FM
GNPLA
C
AAA
N
A
S
L
AILESGDWQ
Q
QVADIEV
Q
L
R
E
Q
L
AP
A
R
N
A-EMVA
DVR
V
LG
fig|340197.5.peg.4516
Escherichia coli F11 (1-344/410)
MTS
P
LP
V
Y
P
V
A
---
--S
AEG
CE
L
I
L
S
D
G
RR
L
VD
GMS
SW
WAALH
G
Y
N
HP
Q
L
N
AA
M
-
K
S
Q
IDAMS
H
VMFGGITH
A
PA
I
E
L
C
R
K
L
VAMT
P
QPL-EC
V
FLAD
SGS
V
A
V
E
V
A
M
K
M
A
L
QYWQAKGEA
-
R
QRF
L
T
F
R
N
G
YHG
D
T
--------
FG
A
MS
V
CDPDNS
M
HSLWK
G
YL
P
E
N
LFAPAPQSRMDGEWDERDMVGFARLMA-
-
AHRHEI
AA
V
I
I
EP
IV
QG
A
GG
MRMYH
PE
W
L
KR
I
R
K
M
CD
R
E
GILLI
A
DE
I
AT
G
FG
RTG
K
LFA
CEHAEIA
PD
I
L
C
L
G
K
A
L
T
GG
T
M
T
L
S
A
TL
T
T
R
EV
A
E
T
IS
N
G
E
AG
CFMH
G
P
T
FM
GNPLA
C
AAA
N
A
S
L
AILESGDWQ
H
QVAAIEG
Q
L
R
E
Q
L
AP
T
C
D
A-EMVA
DVR
V
LG
fig|749550.3.peg.3797
Escherichia coli MS 200-1 (1-344/410)
MTS
P
LP
V
Y
P
V
A
---
--S
AEG
CE
L
I
L
S
D
G
RR
L
VD
GMS
SW
WAALH
G
Y
N
HP
Q
L
N
AA
M
-
K
S
Q
IDAMS
H
VMFGGITH
A
PA
I
E
L
C
R
K
L
VAMT
P
QPL-EC
V
FLAD
SGS
V
A
V
E
V
A
M
K
M
A
L
QYWQAKGEA
-
R
QRF
L
T
F
R
N
G
YHG
D
T
--------
FG
A
MS
V
CDPDNS
M
HSLWK
G
YL
P
E
N
LFAPAPQSRMDGEWDERDMVGFARLMA-
-
AHRHEI
AA
V
I
I
EP
IV
QG
A
GG
MRMYH
PE
W
L
KR
I
R
K
M
CD
R
E
GILLI
A
DE
I
AT
G
FG
RTG
K
LFA
CEHAEIA
PD
I
L
C
L
G
K
A
L
T
GG
T
M
T
L
S
A
TL
T
T
R
EV
A
E
T
IS
N
G
E
AG
CFMH
G
P
T
FM
GNPLA
C
AAA
N
A
S
L
AILESGDWQ
H
QVAAIEG
Q
L
R
E
Q
L
AP
T
C
D
A-EMVA
DVR
V
LG
fig|340197.3.peg.4324
Escherichia coli F11 (57-400/466)
MTS
P
LP
V
Y
P
V
A
---
--S
AEG
CE
L
I
L
S
D
G
RR
L
VD
GMS
SW
WAALH
G
Y
N
HP
Q
L
N
AA
M
-
K
S
Q
IDAMS
H
VMFGGITH
A
PA
I
E
L
C
R
K
L
VAMT
P
QPL-EC
V
FLAD
SGS
V
A
V
E
V
A
M
K
M
A
L
QYWQAKGEA
-
R
QRF
L
T
F
R
N
G
YHG
D
T
--------
FG
A
MS
V
CDPDNS
M
HSLWK
G
YL
P
E
N
LFAPAPQSRMDGEWDERDMVGFARLMA-
-
AHRHEI
AA
V
I
I
EP
IV
QG
A
GG
MRMYH
PE
W
L
KR
I
R
K
M
CD
R
E
GILLI
A
DE
I
AT
G
FG
RTG
K
LFA
CEHAEIA
PD
I
L
C
L
G
K
A
L
T
GG
T
M
T
L
S
A
TL
T
T
R
EV
A
E
T
IS
N
G
E
AG
CFMH
G
P
T
FM
GNPLA
C
AAA
N
A
S
L
AILESGDWQ
H
QVAAIEG
Q
L
R
E
Q
L
AP
T
C
D
A-EMVA
DVR
V
LG
fig|749531.3.peg.1783
Escherichia coli MS 69-1 (1-344/410)
MTS
P
LP
V
Y
P
V
A
---
--S
AEG
CE
L
I
L
S
D
G
RR
L
VD
GMS
SW
WAAIH
G
Y
N
HP
Q
L
N
AA
M
-
K
S
Q
IDAMS
H
VMFGGITH
A
PA
I
E
L
C
R
K
L
VAMT
P
QPL-EC
V
FLAD
SGS
V
A
V
E
V
A
M
K
M
A
L
QYWQAKGEA
-
R
QRF
L
T
F
R
N
G
YHG
D
T
--------
FG
A
MS
V
CDPDNS
M
HSLWK
G
YL
P
E
N
LFAPAPQSRMDGEWDERDMVGFARLMA-
-
AHRHEI
AA
V
I
I
EP
IV
QG
A
GG
MRIYH
PE
W
L
KR
I
R
K
M
CD
R
E
GILLI
A
DE
I
AT
G
FG
RTG
K
LFA
CEHADIA
PD
I
L
C
L
G
K
A
L
T
GG
T
M
T
L
S
A
TL
T
T
R
EV
A
E
T
IS
N
G
E
AG
CFMH
G
P
T
FM
GNPLA
C
AAA
N
A
S
L
AILESGDWQ
H
QVAAIEG
Q
L
R
E
Q
L
AP
A
C
D
A-EMVA
DVR
V
LG
fig|656417.3.peg.958
Escherichia coli M605 (1-344/410)
MTS
P
LP
V
Y
P
V
A
---
--S
AEG
CE
L
I
L
S
D
G
RR
L
VD
GMS
SW
WAAIH
G
Y
N
HP
Q
L
N
AA
M
-
K
S
Q
IDAMS
H
VMFGGITH
A
PA
I
E
L
C
R
K
L
VAMT
P
QPL-EC
V
FLAD
SGS
V
A
V
E
V
A
M
K
M
A
L
QYWQAKGEA
-
R
QRF
L
T
F
R
N
G
YHG
D
T
--------
FG
A
MS
V
CDPDNS
M
HNLWK
G
YL
P
E
N
LFAPAPQSRMDGEWDERDMVGFARLMA-
-
AHRHEI
AA
V
I
I
EP
IV
QG
A
GG
MRMYH
PE
W
L
KR
I
R
K
M
CD
R
E
GILLI
A
DE
I
AT
G
FG
RTG
K
LFA
CEHAEIA
PD
I
L
C
L
G
K
A
L
T
GG
T
M
T
L
S
A
TL
T
T
R
EV
A
E
T
IS
N
G
E
AG
CFMH
G
P
T
FM
GNPLA
C
AAA
N
A
S
L
AILESGDWQ
H
QVAAIEG
Q
L
R
E
Q
L
AP
A
C
D
A-GMVA
DVR
V
LG
fig|550672.3.peg.1011
Escherichia coli B088 (1-325/391)
M
S
D
G
RR
L
VD
GMS
SW
WAAIH
G
Y
N
HP
Q
L
N
AA
M
-
K
S
Q
IDAMS
H
VMFGGITH
A
PA
I
E
L
C
R
K
L
VAMT
P
QPL-EC
V
FLAD
SGS
V
A
V
E
V
A
M
K
M
A
L
QYWQAKGEA
-
R
QRF
L
T
F
R
N
G
YHG
D
T
--------
FG
A
MS
V
CDPDNS
M
HSLWK
G
YL
P
E
N
LFAPAPQSRMDGEWDERDMVGFARLMA-
-
AHRHEI
AA
V
I
I
EP
IV
QG
A
GG
MRMYH
PE
W
L
KR
I
R
K
M
CD
R
E
GILLI
A
DE
I
AT
G
FG
RTG
K
LFA
CEHAEIA
PD
I
L
C
L
G
K
A
L
T
GG
T
M
T
L
S
A
TL
T
T
R
EV
A
E
T
IS
N
G
E
AG
CFMH
G
P
T
FM
GNPLA
C
AAA
N
A
S
L
AILESGDWQ
Q
QVAAIEV
Q
L
R
E
Q
L
AP
A
R
D
A-EMVA
DVR
V
LG
fig|478005.5.peg.1392
Escherichia coli O157:H7 str. EC4486 (1-325/391)
M
S
D
G
RR
L
VD
GMS
SW
WAAIH
G
Y
N
HP
Q
L
N
AA
M
-
K
S
Q
IDAMS
H
VMFGGITH
A
PA
I
E
L
C
R
K
L
VAMT
P
QPL-EC
V
FLAD
SGS
V
A
V
E
V
A
M
K
M
A
L
QYWQAKGEA
-
R
QHF
L
T
F
R
N
G
YHG
D
T
--------
FG
A
MS
V
CDPDNS
M
HSLWK
G
YL
P
E
N
LFAPAPQSRMDGEWDERDMVGFARLMA-
-
AHRHEI
AA
V
I
I
EP
IV
QG
A
GG
MRMYH
PE
W
L
KR
I
R
K
M
CD
R
E
GILLI
A
DE
I
AT
G
FG
RTG
K
LFA
CEHAEIA
PD
I
L
C
L
G
K
A
L
T
GG
T
M
T
L
S
A
TL
T
T
R
EV
A
E
T
IS
N
G
E
AG
CFMH
G
P
T
FM
GNPLA
C
AAA
N
A
S
L
AILESGDWQ
Q
QVAAIEV
Q
L
R
E
Q
L
AP
A
R
D
A-EMVA
DVR
V
LG
fig|656444.3.peg.3769
Escherichia coli TA280 (22-352/426)
I
H
PI
F
A
D
-
---
--R
AE
N
CR
V
W
D
V
EG
RE
Y
L
D
FAG
GI
AVLNT
GH
L
HP
K
V
V
AAV
-
E
A
Q
LKKLS
H
TCFQVLAY
E
PY
L
E
L
C
E
I
M
NQKV
P
GDFAKK
T
LLVT
T
GSEA
V
E
N
A
V
K
I
AR
AATK-----
-
R
SGT
I
A
F
S
G
A
YHG
R
T
--------
HY
T
LA
L
TGKVNP
-
YSAGM
G
LM
P
G
H
VYRALYPCPLHGISEDDAIASIHRIFKN
D
AAPEDI
AAI
V
I
EPV
-
QG
E
GG
FYAAT
P
A
F
M
QR
LR
A
LCDE
H
GI
M
LI
A
DEV
QS
G
AG
RTG
T
LFA
MEQMGVA
PDL
T
T
F
AK
S
I
A
GG
-
F
PL
A
G
VT
G
R
AEVM
D
A
VA
PG
G
--
---L
G
G
T
YA
GNP
I
A
C
V
AA
L
E
V
L
KVFEQENLL
Q
KANDLGH
K
L
K
D
E
L
LA
I
A
E
KHPEIG
DVRGLG
fig|656393.3.peg.3644
Escherichia coli H299 (22-352/426)
I
H
PI
F
A
D
-
---
--R
AE
N
CR
V
W
D
V
EG
RE
Y
L
D
FAG
GI
AVLNT
GH
L
HP
K
V
V
AAV
-
E
A
Q
LKKLS
H
TCFQVLAY
E
PY
L
E
L
C
E
I
M
NQKV
P
GDFAKK
T
LLVT
T
GSEA
V
E
N
A
V
K
I
AR
AATK-----
-
R
SGT
I
A
F
S
G
A
YHG
R
T
--------
HY
T
LA
L
TGKVNP
-
YSAGM
G
LM
P
G
H
VYRALYPCPLHGISEDDAIASIHRIFKN
D
AAPEDI
AAI
V
I
EPV
-
QG
E
GG
FYAAT
P
A
F
M
QR
LR
A
LCDE
H
GI
M
LI
A
DEV
QS
G
AG
RTG
T
LFA
MEQMDVA
PDL
T
T
F
AK
S
I
A
GG
-
F
PL
A
G
VT
G
R
AEVM
D
A
VA
PG
G
--
---L
G
G
T
YA
GNP
I
A
C
V
AA
L
E
V
L
KVFEQENLL
Q
KANDLGH
K
L
K
D
G
L
LA
I
A
E
KHPEIG
DVRGLG
fig|670897.3.peg.1275
Escherichia coli 2362-75 (22-352/426)
I
H
PI
F
A
D
-
---
--R
AE
N
CR
V
W
D
V
EG
RE
Y
L
D
FAG
GI
AVLNT
GH
L
HP
K
V
V
AAV
-
E
A
Q
LKKLS
H
TCFQVLAY
E
PY
L
E
L
C
E
I
M
NQKV
P
GDFAKK
T
LLVT
T
GSEA
V
E
N
A
V
K
I
AR
AATK-----
-
R
SGT
I
A
F
S
G
A
YHG
R
T
--------
HY
T
LA
L
TGKVNP
-
YSAGM
G
LM
P
G
H
VYRALYPCPLHGISEDDAIASIHRIFKN
D
AAPEDI
AAI
V
I
EPV
-
QG
E
GG
FYAAT
P
A
F
M
QR
LR
A
LCDE
H
GI
M
LI
A
DEV
QS
G
AG
RTG
T
LFA
MEQMGVA
PDL
T
T
F
AK
S
I
A
GG
-
F
PL
A
G
VT
G
R
AEVM
D
A
VA
PG
G
--
---L
G
G
T
YA
GNP
I
A
C
V
AA
L
E
V
L
KVFEQENLL
Q
KANVLGQ
K
L
K
D
G
L
LA
I
A
E
KHPEIG
DVRGLG
fig|525281.3.peg.4393
Escherichia coli 83972 (22-352/426)
I
H
PI
F
A
D
-
---
--R
AE
N
CR
V
W
D
V
EG
RE
Y
L
D
FAG
GI
AVLNT
GH
L
HP
K
V
V
AAV
-
E
A
Q
LKKLS
H
TCFQVLAY
E
PY
L
E
L
C
E
I
M
NQKV
P
GDFAKK
T
LLVT
T
GSEA
V
E
N
A
V
K
I
AR
AATK-----
-
R
SGT
I
A
F
S
G
A
YHG
R
T
--------
HY
T
LA
L
TGKVNP
-
YSAGM
G
LM
P
G
H
VYRALYPCPLHGISEDDAIASIHRIFKN
D
AAPEDI
AAI
V
I
EPV
-
QG
E
GG
FYAAT
P
A
F
M
QR
LR
A
LCDE
H
GI
M
LI
A
DEV
QS
G
AG
RTG
T
LFA
MEQMGVA
PDL
T
T
F
AK
S
I
A
GG
-
F
PL
A
G
VT
G
R
AEVM
D
A
VA
PG
G
--
---L
G
G
T
YA
GNP
I
A
C
V
AA
L
E
V
L
KVFEQENLL
Q
KANVLGQ
K
L
K
D
G
L
LA
I
A
E
KHPEIG
DVRGLG
fig|655817.3.peg.3044
Escherichia coli ABU 83972 (22-352/426)
I
H
PI
F
A
D
-
---
--R
AE
N
CR
V
W
D
V
EG
RE
Y
L
D
FAG
GI
AVLNT
GH
L
HP
K
V
V
AAV
-
E
A
Q
LKKLS
H
TCFQVLAY
E
PY
L
E
L
C
E
I
M
NQKV
P
GDFAKK
T
LLVT
T
GSEA
V
E
N
A
V
K
I
AR
AATK-----
-
R
SGT
I
A
F
S
G
A
YHG
R
T
--------
HY
T
LA
L
TGKVNP
-
YSAGM
G
LM
P
G
H
VYRALYPCPLHGISEDDAIASIHRIFKN
D
AAPEDI
AAI
V
I
EPV
-
QG
E
GG
FYAAT
P
A
F
M
QR
LR
A
LCDE
H
GI
M
LI
A
DEV
QS
G
AG
RTG
T
LFA
MEQMGVA
PDL
T
T
F
AK
S
I
A
GG
-
F
PL
A
G
VT
G
R
AEVM
D
A
VA
PG
G
--
---L
G
G
T
YA
GNP
I
A
C
V
AA
L
E
V
L
KVFEQENLL
Q
KANVLGQ
K
L
K
D
G
L
LA
I
A
E
KHPEIG
DVRGLG
fig|550677.3.peg.3193
Escherichia coli B354 (22-352/426)
I
H
PI
F
A
D
-
---
--R
AE
N
CR
V
W
D
V
EG
RE
Y
L
D
FAG
GI
AVLNT
GH
L
HP
K
V
V
AAV
-
E
A
Q
LKKLS
H
TCFQVLAY
E
PY
L
E
L
C
E
I
M
NQKV
P
GDFAKK
T
LLVT
T
GSEA
V
E
N
A
V
K
I
AR
AATK-----
-
R
SGT
I
A
F
S
G
A
YHG
R
T
--------
HY
T
LA
L
TGKVNP
-
YSAGM
G
LM
P
G
H
VYRALYPCPLHGISEDDAIASIHRIFKN
D
AAPEDI
AAI
V
I
EPV
-
QG
E
GG
FYAAT
P
A
F
M
QR
LR
A
LCDE
H
GI
M
LI
A
DEV
QS
G
AG
RTG
T
LFA
MEQMGVA
PDL
T
T
F
AK
S
I
A
GG
-
F
PL
A
G
VT
G
R
AEVM
D
A
VA
PG
G
--
---L
G
G
T
YA
GNP
I
A
C
V
AA
L
E
V
L
KVFEQENLL
Q
KANVLGQ
K
L
K
D
G
L
LA
I
A
E
KHPEIG
DVRGLG
fig|199310.1.peg.3135
Escherichia coli CFT073 (24-354/428)
I
H
PI
F
A
D
-
---
--R
AE
N
CR
V
W
D
V
EG
RE
Y
L
D
FAG
GI
AVLNT
GH
L
HP
K
V
V
AAV
-
E
A
Q
LKKLS
H
TCFQVLAY
E
PY
L
E
L
C
E
I
M
NQKV
P
GDFAKK
T
LLVT
T
GSEA
V
E
N
A
V
K
I
AR
AATK-----
-
R
SGT
I
A
F
S
G
A
YHG
R
T
--------
HY
T
LA
L
TGKVNP
-
YSAGM
G
LM
P
G
H
VYRALYPCPLHGISEDDAIASIHRIFKN
D
AAPEDI
AAI
V
I
EPV
-
QG
E
GG
FYAAT
P
A
F
M
QR
LR
A
LCDE
H
GI
M
LI
A
DEV
QS
G
AG
RTG
T
LFA
MEQMGVA
PDL
T
T
F
AK
S
I
A
GG
-
F
PL
A
G
VT
G
R
AEVM
D
A
VA
PG
G
--
---L
G
G
T
YA
GNP
I
A
C
V
AA
L
E
V
L
KVFEQENLL
Q
KANVLGQ
K
L
K
D
G
L
LA
I
A
E
KHPEIG
DVRGLG
fig|199310.4.peg.3022
Escherichia coli CFT073 (22-352/426)
I
H
PI
F
A
D
-
---
--R
AE
N
CR
V
W
D
V
EG
RE
Y
L
D
FAG
GI
AVLNT
GH
L
HP
K
V
V
AAV
-
E
A
Q
LKKLS
H
TCFQVLAY
E
PY
L
E
L
C
E
I
M
NQKV
P
GDFAKK
T
LLVT
T
GSEA
V
E
N
A
V
K
I
AR
AATK-----
-
R
SGT
I
A
F
S
G
A
YHG
R
T
--------
HY
T
LA
L
TGKVNP
-
YSAGM
G
LM
P
G
H
VYRALYPCPLHGISEDDAIASIHRIFKN
D
AAPEDI
AAI
V
I
EPV
-
QG
E
GG
FYAAT
P
A
F
M
QR
LR
A
LCDE
H
GI
M
LI
A
DEV
QS
G
AG
RTG
T
LFA
MEQMGVA
PDL
T
T
F
AK
S
I
A
GG
-
F
PL
A
G
VT
G
R
AEVM
D
A
VA
PG
G
--
---L
G
G
T
YA
GNP
I
A
C
V
AA
L
E
V
L
KVFEQENLL
Q
KANVLGQ
K
L
K
D
G
L
LA
I
A
E
KHPEIG
DVRGLG
fig|216593.1.peg.993
Escherichia coli E2348/69 (22-352/426)
I
H
PI
F
A
D
-
---
--R
AE
N
CR
V
W
D
V
EG
RE
Y
L
D
FAG
GI
AVLNT
GH
L
HP
K
V
V
AAV
-
E
A
Q
LKKLS
H
TCFQVLAY
E
PY
L
E
L
C
E
I
M
NQKV
P
GDFAKK
T
LLVT
T
GSEA
V
E
N
A
V
K
I
AR
AATK-----
-
R
SGT
I
A
F
S
G
A
YHG
R
T
--------
HY
T
LA
L
TGKVNP
-
YSAGM
G
LM
P
G
H
VYRALYPCPLHGISEDDAIASIHRIFKN
D
AAPEDI
AAI
V
I
EPV
-
QG
E
GG
FYAAT
P
A
F
M
QR
LR
A
LCDE
H
GI
M
LI
A
DEV
QS
G
AG
RTG
T
LFA
MEQMGVA
PDL
T
T
F
AK
S
I
A
GG
-
F
PL
A
G
VT
G
R
AEVM
D
A
VA
PG
G
--
---L
G
G
T
YA
GNP
I
A
C
V
AA
L
E
V
L
KVFEQENLL
Q
KANVLGQ
K
L
K
D
G
L
LA
I
A
E
KHPEIG
DVRGLG
fig|749546.3.peg.4203
Escherichia coli MS 185-1 (22-352/426)
I
H
PI
F
A
D
-
---
--R
AE
N
CR
V
W
D
V
EG
RE
Y
L
D
FAG
GI
AVLNT
GH
L
HP
K
V
V
AAV
-
E
A
Q
LKKLS
H
TCFQVLAY
E
PY
L
E
L
C
E
I
M
NQKV
P
GDFAKK
T
LLVT
T
GSEA
V
E
N
A
V
K
I
AR
AATK-----
-
R
SGT
I
A
F
S
G
A
YHG
R
T
--------
HY
T
LA
L
TGKVNP
-
YSAGM
G
LM
P
G
H
VYRALYPCPLHGISEDDAIASIHRIFKN
D
AAPEDI
AAI
V
I
EPV
-
QG
E
GG
FYAAT
P
A
F
M
QR
LR
A
LCDE
H
GI
M
LI
A
DEV
QS
G
AG
RTG
T
LFA
MEQMGVA
PDL
T
T
F
AK
S
I
A
GG
-
F
PL
A
G
VT
G
R
AEVM
D
A
VA
PG
G
--
---L
G
G
T
YA
GNP
I
A
C
V
AA
L
E
V
L
KVFEQENLL
Q
KANVLGQ
K
L
K
D
G
L
LA
I
A
E
KHPEIG
DVRGLG
fig|749527.3.peg.5455
Escherichia coli MS 21-1 (22-352/426)
I
H
PI
F
A
D
-
---
--R
AE
N
CR
V
W
D
V
EG
RE
Y
L
D
FAG
GI
AVLNT
GH
L
HP
K
V
V
AAV
-
E
A
Q
LKKLS
H
TCFQVLAY
E
PY
L
E
L
C
E
I
M
NQKV
P
GDFAKK
T
LLVT
T
GSEA
V
E
N
A
V
K
I
AR
AATK-----
-
R
SGT
I
A
F
S
G
A
YHG
R
T
--------
HY
T
LA
L
TGKVNP
-
YSAGM
G
LM
P
G
H
VYRALYPCPLHGISEDDAIASIHRIFKN
D
AAPEDI
AAI
V
I
EPV
-
QG
E
GG
FYAAT
P
A
F
M
QR
LR
A
LCDE
H
GI
M
LI
A
DEV
QS
G
AG
RTG
T
LFA
MEQMGVA
PDL
T
T
F
AK
S
I
A
GG
-
F
PL
A
G
VT
G
R
AEVM
D
A
VA
PG
G
--
---L
G
G
T
YA
GNP
I
A
C
V
AA
L
E
V
L
KVFEQENLL
Q
KANVLGQ
K
L
K
D
G
L
LA
I
A
E
KHPEIG
DVRGLG
fig|749528.3.peg.3331
Escherichia coli MS 45-1 (22-352/426)
I
H
PI
F
A
D
-
---
--R
AE
N
CR
V
W
D
V
EG
RE
Y
L
D
FAG
GI
AVLNT
GH
L
HP
K
V
V
AAV
-
E
A
Q
LKKLS
H
TCFQVLAY
E
PY
L
E
L
C
E
I
M
NQKV
P
GDFAKK
T
LLVT
T
GSEA
V
E
N
A
V
K
I
AR
AATK-----
-
R
SGT
I
A
F
S
G
A
YHG
R
T
--------
HY
T
LA
L
TGKVNP
-
YSAGM
G
LM
P
G
H
VYRALYPCPLHGISEDDAIASIHRIFKN
D
AAPEDI
AAI
V
I
EPV
-
QG
E
GG
FYAAT
P
A
F
M
QR
LR
A
LCDE
H
GI
M
LI
A
DEV
QS
G
AG
RTG
T
LFA
MEQMGVA
PDL
T
T
F
AK
S
I
A
GG
-
F
PL
A
G
VT
G
R
AEVM
D
A
VA
PG
G
--
---L
G
G
T
YA
GNP
I
A
C
V
AA
L
E
V
L
KVFEQENLL
Q
KANVLGQ
K
L
K
D
G
L
LA
I
A
E
KHPEIG
DVRGLG
fig|574521.7.peg.2966
Escherichia coli O127:H6 str. E2348/69 (22-352/426)
I
H
PI
F
A
D
-
---
--R
AE
N
CR
V
W
D
V
EG
RE
Y
L
D
FAG
GI
AVLNT
GH
L
HP
K
V
V
AAV
-
E
A
Q
LKKLS
H
TCFQVLAY
E
PY
L
E
L
C
E
I
M
NQKV
P
GDFAKK
T
LLVT
T
GSEA
V
E
N
A
V
K
I
AR
AATK-----
-
R
SGT
I
A
F
S
G
A
YHG
R
T
--------
HY
T
LA
L
TGKVNP
-
YSAGM
G
LM
P
G
H
VYRALYPCPLHGISEDDAIASIHRIFKN
D
AAPEDI
AAI
V
I
EPV
-
QG
E
GG
FYAAT
P
A
F
M
QR
LR
A
LCDE
H
GI
M
LI
A
DEV
QS
G
AG
RTG
T
LFA
MEQMGVA
PDL
T
T
F
AK
S
I
A
GG
-
F
PL
A
G
VT
G
R
AEVM
D
A
VA
PG
G
--
---L
G
G
T
YA
GNP
I
A
C
V
AA
L
E
V
L
KVFEQENLL
Q
KANVLGQ
K
L
K
D
G
L
LA
I
A
E
KHPEIG
DVRGLG
fig|431946.3.peg.2571
Escherichia coli SE15 (22-352/426)
I
H
PI
F
A
D
-
---
--R
AE
N
CR
V
W
D
V
EG
RE
Y
L
D
FAG
GI
AVLNT
GH
L
HP
K
V
V
AAV
-
E
A
Q
LKKLS
H
TCFQVLAY
E
PY
L
E
L
C
E
I
M
NQKV
P
GDFAKK
T
LLVT
T
GSEA
V
E
N
A
V
K
I
AR
AATK-----
-
R
SGT
I
A
F
S
G
A
YHG
R
T
--------
HY
T
LA
L
TGKVNP
-
YSAGM
G
LM
P
G
H
VYRALYPCPLHGISEDDAIASIHRIFKN
D
AAPEDI
AAI
V
I
EPV
-
QG
E
GG
FYAAT
P
A
F
M
QR
LR
A
LCDE
H
GI
M
LI
A
DEV
QS
G
AG
RTG
T
LFA
MEQMGVA
PDL
T
T
F
AK
S
I
A
GG
-
F
PL
A
G
VT
G
R
AEVM
D
A
VA
PG
G
--
---L
G
G
T
YA
GNP
I
A
C
V
AA
L
E
V
L
KVFEQENLL
Q
KANVLGQ
K
L
K
D
G
L
LA
I
A
E
KHPEIG
DVRGLG
fig|439855.10.peg.2940
Escherichia coli SMS-3-5 (22-352/426)
I
H
PI
F
A
D
-
---
--R
AE
N
CR
V
W
D
V
EG
RE
Y
L
D
FAG
GI
AVLNT
GH
L
HP
K
V
V
AAV
-
E
A
Q
LKKLS
H
TCFQVLAY
E
PY
L
E
L
C
E
I
M
NQKV
P
GDFAKK
T
LLVT
T
GSEA
V
E
N
A
V
K
I
AR
AATK-----
-
R
SGT
I
A
F
S
G
A
YHG
R
T
--------
HY
T
LA
L
TGKVNP
-
YSAGM
G
LM
P
G
H
VYRALYPCPLHGISEDDAIASIHRIFKN
D
AAPEDI
AAI
V
I
EPV
-
QG
E
GG
FYAAT
P
A
F
M
QR
LR
A
LCDE
H
GI
M
LI
A
DEV
QS
G
AG
RTG
T
LFA
MEQMGVA
PDL
T
T
F
AK
S
I
A
GG
-
F
PL
A
G
VT
G
R
AEVM
D
A
VA
PG
G
--
---L
G
G
T
YA
GNP
I
A
C
V
AA
L
E
V
L
KVFEQENLL
Q
KANVLGQ
K
L
K
D
G
L
LA
I
A
E
KHPEIG
DVRGLG
fig|656440.3.peg.2675
Escherichia coli TA206 (22-352/426)
I
H
PI
F
A
D
-
---
--R
AE
N
CR
V
W
D
V
EG
RE
Y
L
D
FAG
GI
AVLNT
GH
L
HP
K
V
V
AAV
-
E
A
Q
LKKLS
H
TCFQVLAY
E
PY
L
E
L
C
E
I
M
NQKV
P
GDFAKK
T
LLVT
T
GSEA
V
E
N
A
V
K
I
AR
AATK-----
-
R
SGT
I
A
F
S
G
A
YHG
R
T
--------
HY
T
LA
L
TGKVNP
-
YSAGM
G
LM
P
G
H
VYRALYPCPLHGISEDDAIASIHRIFKN
D
AAPEDI
AAI
V
I
EPV
-
QG
E
GG
FYAAT
P
A
F
M
QR
LR
A
LCDE
H
GI
M
LI
A
DEV
QS
G
AG
RTG
T
LFA
MEQMGVA
PDL
T
T
F
AK
S
I
A
GG
-
F
PL
A
G
VT
G
R
AEVM
D
A
VA
PG
G
--
---L
G
G
T
YA
GNP
I
A
C
V
AA
L
E
V
L
KVFEQENLL
Q
KANVLGQ
K
L
K
D
G
L
LA
I
A
E
KHPEIG
DVRGLG
fig|550676.3.peg.2586
Escherichia coli B185 (22-352/426)
I
H
PI
F
A
D
-
---
--R
AE
N
CR
V
W
D
V
EG
RE
Y
L
D
FAG
GI
AVLNT
GH
L
HP
K
V
V
AAV
-
E
A
Q
LKKLS
H
TCFQVLAY
E
PY
L
E
L
C
E
I
M
NQKV
P
GDFAKK
T
LLVT
T
GSEA
V
E
N
A
V
K
I
AR
AATK-----
-
R
SGT
I
A
F
S
G
A
YHG
R
T
--------
HY
T
LA
L
TGKVNP
-
YSAGM
G
LM
P
G
H
VYRALYPCPLHGISEDDAIASIHRIFKN
D
AAPEDI
AAI
V
I
EPV
-
QG
E
GG
FYAAT
P
A
F
M
QR
LR
A
LCDE
H
GI
M
LI
A
DEV
QS
G
AG
RTG
T
LFA
MEQMGVA
PDL
T
T
F
AK
S
I
A
GG
-
F
PL
A
G
VT
G
R
AEVM
D
A
VA
PG
A
--
---L
G
G
T
YA
GNP
I
A
C
V
AA
L
E
V
L
KVFEQENLL
Q
KANDLGQ
K
L
K
D
G
L
LA
I
A
E
KHPEIG
DVRGLG
fig|595496.3.peg.2635
Escherichia coli BW2952 (22-352/426)
I
H
PI
F
A
D
-
---
--R
AE
N
CR
V
W
D
V
EG
RE
Y
L
D
FAG
GI
AVLNT
GH
L
HP
K
V
V
AAV
-
E
A
Q
LKKLS
H
TCFQVLAY
E
PY
L
E
L
C
E
I
M
NQKV
P
GDFAKK
T
LLVT
T
GSEA
V
E
N
A
V
K
I
AR
AATK-----
-
R
SGT
I
A
F
S
G
A
YHG
R
T
--------
HY
T
LA
L
TGKVNP
-
YSAGM
G
LM
P
G
H
VYRALYPCPLHGISEDDAIASIHRIFKN
D
AAPEDI
AAI
V
I
EPV
-
QG
E
GG
FYASS
P
A
F
M
QR
LR
A
LCDE
H
GI
M
LI
A
DEV
QS
G
AG
RTG
T
LFA
MEQMGVA
PDL
T
T
F
AK
S
I
A
GG
-
F
PL
A
G
VT
G
R
AEVM
D
A
VA
PG
G
--
---L
G
G
T
YA
GNP
I
A
C
V
AA
L
E
V
L
KVFEQENLL
Q
KANDLGQ
K
L
K
D
G
L
LA
I
A
E
KHPEIG
DVRGLG
fig|536056.3.peg.1074
Escherichia coli DH1 (22-352/426)
I
H
PI
F
A
D
-
---
--R
AE
N
CR
V
W
D
V
EG
RE
Y
L
D
FAG
GI
AVLNT
GH
L
HP
K
V
V
AAV
-
E
A
Q
LKKLS
H
TCFQVLAY
E
PY
L
E
L
C
E
I
M
NQKV
P
GDFAKK
T
LLVT
T
GSEA
V
E
N
A
V
K
I
AR
AATK-----
-
R
SGT
I
A
F
S
G
A
YHG
R
T
--------
HY
T
LA
L
TGKVNP
-
YSAGM
G
LM
P
G
H
VYRALYPCPLHGISEDDAIASIHRIFKN
D
AAPEDI
AAI
V
I
EPV
-
QG
E
GG
FYASS
P
A
F
M
QR
LR
A
LCDE
H
GI
M
LI
A
DEV
QS
G
AG
RTG
T
LFA
MEQMGVA
PDL
T
T
F
AK
S
I
A
GG
-
F
PL
A
G
VT
G
R
AEVM
D
A
VA
PG
G
--
---L
G
G
T
YA
GNP
I
A
C
V
AA
L
E
V
L
KVFEQENLL
Q
KANDLGQ
K
L
K
D
G
L
LA
I
A
E
KHPEIG
DVRGLG
fig|316401.4.peg.3235
Escherichia coli ETEC H10407 (22-352/426)
I
H
PI
F
A
D
-
---
--R
AE
N
CR
V
W
D
V
EG
RE
Y
L
D
FAG
GI
AVLNT
GH
L
HP
K
V
V
AAV
-
E
A
Q
LKKLS
H
TCFQVLAY
E
PY
L
E
L
C
E
I
M
NQKV
P
GDFAKK
T
LLVT
T
GSEA
V
E
N
A
V
K
I
AR
AATK-----
-
R
SGT
I
A
F
S
G
A
YHG
R
T
--------
HY
T
LA
L
TGKVNP
-
YSAGM
G
LM
P
G
H
VYRALYPCPLHGISEDDAIASIHRIFKN
D
AAPEDI
AAI
V
I
EPV
-
QG
E
GG
FYASS
P
A
F
M
QR
LR
A
LCDE
H
GI
M
LI
A
DEV
QS
G
AG
RTG
T
LFA
MEQMGVA
PDL
T
T
F
AK
S
I
A
GG
-
F
PL
A
G
VT
G
R
AEVM
D
A
VA
PG
G
--
---L
G
G
T
YA
GNP
I
A
C
V
AA
L
E
V
L
KVFEQENLL
Q
KANDLGQ
K
L
K
D
G
L
LA
I
A
E
KHPEIG
DVRGLG
fig|656414.3.peg.3096
Escherichia coli H736 (22-352/426)
I
H
PI
F
A
D
-
---
--R
AE
N
CR
V
W
D
V
EG
RE
Y
L
D
FAG
GI
AVLNT
GH
L
HP
K
V
V
AAV
-
E
A
Q
LKKLS
H
TCFQVLAY
E
PY
L
E
L
C
E
I
M
NQKV
P
GDFAKK
T
LLVT
T
GSEA
V
E
N
A
V
K
I
AR
AATK-----
-
R
SGT
I
A
F
S
G
A
YHG
R
T
--------
HY
T
LA
L
TGKVNP
-
YSAGM
G
LM
P
G
H
VYRALYPCPLHGISEDDAIASIHRIFKN
D
AAPEDI
AAI
V
I
EPV
-
QG
E
GG
FYASS
P
A
F
M
QR
LR
A
LCDE
H
GI
M
LI
A
DEV
QS
G
AG
RTG
T
LFA
MEQMGVA
PDL
T
T
F
AK
S
I
A
GG
-
F
PL
A
G
VT
G
R
AEVM
D
A
VA
PG
G
--
---L
G
G
T
YA
GNP
I
A
C
V
AA
L
E
V
L
KVFEQENLL
Q
KANDLGQ
K
L
K
D
G
L
LA
I
A
E
KHPEIG
DVRGLG
fig|83333.1.peg.2623
Escherichia coli K12 (22-352/426)
I
H
PI
F
A
D
-
---
--R
AE
N
CR
V
W
D
V
EG
RE
Y
L
D
FAG
GI
AVLNT
GH
L
HP
K
V
V
AAV
-
E
A
Q
LKKLS
H
TCFQVLAY
E
PY
L
E
L
C
E
I
M
NQKV
P
GDFAKK
T
LLVT
T
GSEA
V
E
N
A
V
K
I
AR
AATK-----
-
R
SGT
I
A
F
S
G
A
YHG
R
T
--------
HY
T
LA
L
TGKVNP
-
YSAGM
G
LM
P
G
H
VYRALYPCPLHGISEDDAIASIHRIFKN
D
AAPEDI
AAI
V
I
EPV
-
QG
E
GG
FYASS
P
A
F
M
QR
LR
A
LCDE
H
GI
M
LI
A
DEV
QS
G
AG
RTG
T
LFA
MEQMGVA
PDL
T
T
F
AK
S
I
A
GG
-
F
PL
A
G
VT
G
R
AEVM
D
A
VA
PG
G
--
---L
G
G
T
YA
GNP
I
A
C
V
AA
L
E
V
L
KVFEQENLL
Q
KANDLGQ
K
L
K
D
G
L
LA
I
A
E
KHPEIG
DVRGLG
fig|749538.3.peg.2432
Escherichia coli MS 116-1 (22-352/426)
I
H
PI
F
A
D
-
---
--R
AE
N
CR
V
W
D
V
EG
RE
Y
L
D
FAG
GI
AVLNT
GH
L
HP
K
V
V
AAV
-
E
A
Q
LKKLS
H
TCFQVLAY
E
PY
L
E
L
C
E
I
M
NQKV
P
GDFAKK
T
LLVT
T
GSEA
V
E
N
A
V
K
I
AR
AATK-----
-
R
SGT
I
A
F
S
G
A
YHG
R
T
--------
HY
T
LA
L
TGKVNP
-
YSAGM
G
LM
P
G
H
VYRALYPCPLHGISEDDAIASIHRIFKN
D
AAPEDI
AAI
V
I
EPV
-
QG
E
GG
FYASS
P
A
F
M
QR
LR
A
LCDE
H
GI
M
LI
A
DEV
QS
G
AG
RTG
T
LFA
MEQMGVA
PDL
T
T
F
AK
S
I
A
GG
-
F
PL
A
G
VT
G
R
AEVM
D
A
VA
PG
G
--
---L
G
G
T
YA
GNP
I
A
C
V
AA
L
E
V
L
KVFEQENLL
Q
KANDLGQ
K
L
K
D
G
L
LA
I
A
E
KHPEIG
DVRGLG
fig|749540.3.peg.1756
Escherichia coli MS 146-1 (22-352/426)
I
H
PI
F
A
D
-
---
--R
AE
N
CR
V
W
D
V
EG
RE
Y
L
D
FAG
GI
AVLNT
GH
L
HP
K
V
V
AAV
-
E
A
Q
LKKLS
H
TCFQVLAY
E
PY
L
E
L
C
E
I
M
NQKV
P
GDFAKK
T
LLVT
T
GSEA
V
E
N
A
V
K
I
AR
AATK-----
-
R
SGT
I
A
F
S
G
A
YHG
R
T
--------
HY
T
LA
L
TGKVNP
-
YSAGM
G
LM
P
G
H
VYRALYPCPLHGISEDDAIASIHRIFKN
D
AAPEDI
AAI
V
I
EPV
-
QG
E
GG
FYASS
P
A
F
M
QR
LR
A
LCDE
H
GI
M
LI
A
DEV
QS
G
AG
RTG
T
LFA
MEQMGVA
PDL
T
T
F
AK
S
I
A
GG
-
F
PL
A
G
VT
G
R
AEVM
D
A
VA
PG
G
--
---L
G
G
T
YA
GNP
I
A
C
V
AA
L
E
V
L
KVFEQENLL
Q
KANDLGQ
K
L
K
D
G
L
LA
I
A
E
KHPEIG
DVRGLG
fig|749544.3.peg.3066
Escherichia coli MS 175-1 (22-352/426)
I
H
PI
F
A
D
-
---
--R
AE
N
CR
V
W
D
V
EG
RE
Y
L
D
FAG
GI
AVLNT
GH
L
HP
K
V
V
AAV
-
E
A
Q
LKKLS
H
TCFQVLAY
E
PY
L
E
L
C
E
I
M
NQKV
P
GDFAKK
T
LLVT
T
GSEA
V
E
N
A
V
K
I
AR
AATK-----
-
R
SGT
I
A
F
S
G
A
YHG
R
T
--------
HY
T
LA
L
TGKVNP
-
YSAGM
G
LM
P
G
H
VYRALYPCPLHGISEDDAIASIHRIFKN
D
AAPEDI
AAI
V
I
EPV
-
QG
E
GG
FYASS
P
A
F
M
QR
LR
A
LCDE
H
GI
M
LI
A
DEV
QS
G
AG
RTG
T
LFA
MEQMGVA
PDL
T
T
F
AK
S
I
A
GG
-
F
PL
A
G
VT
G
R
AEVM
D
A
VA
PG
G
--
---L
G
G
T
YA
GNP
I
A
C
V
AA
L
E
V
L
KVFEQENLL
Q
KANDLGQ
K
L
K
D
G
L
LA
I
A
E
KHPEIG
DVRGLG
fig|749548.3.peg.3046
Escherichia coli MS 196-1 (22-352/426)
I
H
PI
F
A
D
-
---
--R
AE
N
CR
V
W
D
V
EG
RE
Y
L
D
FAG
GI
AVLNT
GH
L
HP
K
V
V
AAV
-
E
A
Q
LKKLS
H
TCFQVLAY
E
PY
L
E
L
C
E
I
M
NQKV
P
GDFAKK
T
LLVT
T
GSEA
V
E
N
A
V
K
I
AR
AATK-----
-
R
SGT
I
A
F
S
G
A
YHG
R
T
--------
HY
T
LA
L
TGKVNP
-
YSAGM
G
LM
P
G
H
VYRALYPCPLHGISEDDAIASIHRIFKN
D
AAPEDI
AAI
V
I
EPV
-
QG
E
GG
FYASS
P
A
F
M
QR
LR
A
LCDE
H
GI
M
LI
A
DEV
QS
G
AG
RTG
T
LFA
MEQMGVA
PDL
T
T
F
AK
S
I
A
GG
-
F
PL
A
G
VT
G
R
AEVM
D
A
VA
PG
G
--
---L
G
G
T
YA
GNP
I
A
C
V
AA
L
E
V
L
KVFEQENLL
Q
KANDLGQ
K
L
K
D
G
L
LA
I
A
E
KHPEIG
DVRGLG
fig|316407.3.peg.2571
Escherichia coli W3110 (22-352/426)
I
H
PI
F
A
D
-
---
--R
AE
N
CR
V
W
D
V
EG
RE
Y
L
D
FAG
GI
AVLNT
GH
L
HP
K
V
V
AAV
-
E
A
Q
LKKLS
H
TCFQVLAY
E
PY
L
E
L
C
E
I
M
NQKV
P
GDFAKK
T
LLVT
T
GSEA
V
E
N
A
V
K
I
AR
AATK-----
-
R
SGT
I
A
F
S
G
A
YHG
R
T
--------
HY
T
LA
L
TGKVNP
-
YSAGM
G
LM
P
G
H
VYRALYPCPLHGISEDDAIASIHRIFKN
D
AAPEDI
AAI
V
I
EPV
-
QG
E
GG
FYASS
P
A
F
M
QR
LR
A
LCDE
H
GI
M
LI
A
DEV
QS
G
AG
RTG
T
LFA
MEQMGVA
PDL
T
T
F
AK
S
I
A
GG
-
F
PL
A
G
VT
G
R
AEVM
D
A
VA
PG
G
--
---L
G
G
T
YA
GNP
I
A
C
V
AA
L
E
V
L
KVFEQENLL
Q
KANDLGQ
K
L
K
D
G
L
LA
I
A
E
KHPEIG
DVRGLG
fig|316385.5.peg.2783
Escherichia coli str. K-12 substr. DH10B (22-352/426)
I
H
PI
F
A
D
-
---
--R
AE
N
CR
V
W
D
V
EG
RE
Y
L
D
FAG
GI
AVLNT
GH
L
HP
K
V
V
AAV
-
E
A
Q
LKKLS
H
TCFQVLAY
E
PY
L
E
L
C
E
I
M
NQKV
P
GDFAKK
T
LLVT
T
GSEA
V
E
N
A
V
K
I
AR
AATK-----
-
R
SGT
I
A
F
S
G
A
YHG
R
T
--------
HY
T
LA
L
TGKVNP
-
YSAGM
G
LM
P
G
H
VYRALYPCPLHGISEDDAIASIHRIFKN
D
AAPEDI
AAI
V
I
EPV
-
QG
E
GG
FYASS
P
A
F
M
QR
LR
A
LCDE
H
GI
M
LI
A
DEV
QS
G
AG
RTG
T
LFA
MEQMGVA
PDL
T
T
F
AK
S
I
A
GG
-
F
PL
A
G
VT
G
R
AEVM
D
A
VA
PG
G
--
---L
G
G
T
YA
GNP
I
A
C
V
AA
L
E
V
L
KVFEQENLL
Q
KANDLGQ
K
L
K
D
G
L
LA
I
A
E
KHPEIG
DVRGLG
fig|316385.7.peg.2846
Escherichia coli str. K-12 substr. DH10B (22-352/426)
I
H
PI
F
A
D
-
---
--R
AE
N
CR
V
W
D
V
EG
RE
Y
L
D
FAG
GI
AVLNT
GH
L
HP
K
V
V
AAV
-
E
A
Q
LKKLS
H
TCFQVLAY
E
PY
L
E
L
C
E
I
M
NQKV
P
GDFAKK
T
LLVT
T
GSEA
V
E
N
A
V
K
I
AR
AATK-----
-
R
SGT
I
A
F
S
G
A
YHG
R
T
--------
HY
T
LA
L
TGKVNP
-
YSAGM
G
LM
P
G
H
VYRALYPCPLHGISEDDAIASIHRIFKN
D
AAPEDI
AAI
V
I
EPV
-
QG
E
GG
FYASS
P
A
F
M
QR
LR
A
LCDE
H
GI
M
LI
A
DEV
QS
G
AG
RTG
T
LFA
MEQMGVA
PDL
T
T
F
AK
S
I
A
GG
-
F
PL
A
G
VT
G
R
AEVM
D
A
VA
PG
G
--
---L
G
G
T
YA
GNP
I
A
C
V
AA
L
E
V
L
KVFEQENLL
Q
KANDLGQ
K
L
K
D
G
L
LA
I
A
E
KHPEIG
DVRGLG
fig|511145.12.peg.2754
Escherichia coli str. K-12 substr. MG1655 (22-352/426)
I
H
PI
F
A
D
-
---
--R
AE
N
CR
V
W
D
V
EG
RE
Y
L
D
FAG
GI
AVLNT
GH
L
HP
K
V
V
AAV
-
E
A
Q
LKKLS
H
TCFQVLAY
E
PY
L
E
L
C
E
I
M
NQKV
P
GDFAKK
T
LLVT
T
GSEA
V
E
N
A
V
K
I
AR
AATK-----
-
R
SGT
I
A
F
S
G
A
YHG
R
T
--------
HY
T
LA
L
TGKVNP
-
YSAGM
G
LM
P
G
H
VYRALYPCPLHGISEDDAIASIHRIFKN
D
AAPEDI
AAI
V
I
EPV
-
QG
E
GG
FYASS
P
A
F
M
QR
LR
A
LCDE
H
GI
M
LI
A
DEV
QS
G
AG
RTG
T
LFA
MEQMGVA
PDL
T
T
F
AK
S
I
A
GG
-
F
PL
A
G
VT
G
R
AEVM
D
A
VA
PG
G
--
---L
G
G
T
YA
GNP
I
A
C
V
AA
L
E
V
L
KVFEQENLL
Q
KANDLGQ
K
L
K
D
G
L
LA
I
A
E
KHPEIG
DVRGLG
fig|511145.6.peg.2738
Escherichia coli str. K-12 substr. MG1655 (22-352/426)
I
H
PI
F
A
D
-
---
--R
AE
N
CR
V
W
D
V
EG
RE
Y
L
D
FAG
GI
AVLNT
GH
L
HP
K
V
V
AAV
-
E
A
Q
LKKLS
H
TCFQVLAY
E
PY
L
E
L
C
E
I
M
NQKV
P
GDFAKK
T
LLVT
T
GSEA
V
E
N
A
V
K
I
AR
AATK-----
-
R
SGT
I
A
F
S
G
A
YHG
R
T
--------
HY
T
LA
L
TGKVNP
-
YSAGM
G
LM
P
G
H
VYRALYPCPLHGISEDDAIASIHRIFKN
D
AAPEDI
AAI
V
I
EPV
-
QG
E
GG
FYASS
P
A
F
M
QR
LR
A
LCDE
H
GI
M
LI
A
DEV
QS
G
AG
RTG
T
LFA
MEQMGVA
PDL
T
T
F
AK
S
I
A
GG
-
F
PL
A
G
VT
G
R
AEVM
D
A
VA
PG
G
--
---L
G
G
T
YA
GNP
I
A
C
V
AA
L
E
V
L
KVFEQENLL
Q
KANDLGQ
K
L
K
D
G
L
LA
I
A
E
KHPEIG
DVRGLG
fig|1040638.4.peg.3070
Escherichia coli O104:H4 str. LB226692 (22-352/426)
I
H
PI
F
A
D
-
---
--R
AE
N
CR
V
W
D
V
EG
RE
Y
L
D
FAG
GI
AVLNT
GH
L
HP
K
V
V
AAV
-
E
A
Q
LKKLS
H
TCFQVLAY
E
PY
L
E
L
C
E
I
M
NQKV
P
GDFAKK
T
LLVT
T
GSEA
V
E
N
A
V
K
I
AR
AATK-----
-
R
SGT
I
A
F
S
G
A
YHG
R
T
--------
HY
T
LA
L
TGKVNP
-
YSAGM
G
LM
P
G
H
VYRALYPCPLHGISEDDAIASIHRIFKN
D
AAPEDI
AAI
V
I
EPV
-
QG
E
GG
FYAAS
P
A
F
M
QR
LR
A
LCDE
H
GI
M
LI
A
DEV
QS
G
AG
RTG
T
LFA
MEQMGVA
PDL
T
T
F
AK
S
I
A
GG
-
F
PL
A
G
VT
G
R
AEVM
D
A
VA
PG
G
--
---L
G
G
T
YA
GNP
I
A
C
V
AA
L
E
V
L
KVFEQENLL
Q
KANDLGQ
K
L
K
D
G
L
LA
I
A
E
KHPEIG
DVRGLG
fig|6666666.5357.peg.383
Escherichia coli TY-2482 (22-352/426)
I
H
PI
F
A
D
-
---
--R
AE
N
CR
V
W
D
V
EG
RE
Y
L
D
FAG
GI
AVLNT
GH
L
HP
K
V
V
AAV
-
E
A
Q
LKKLS
H
TCFQVLAY
E
PY
L
E
L
C
E
I
M
NQKV
P
GDFAKK
T
LLVT
T
GSEA
V
E
N
A
V
K
I
AR
AATK-----
-
R
SGT
I
A
F
S
G
A
YHG
R
T
--------
HY
T
LA
L
TGKVNP
-
YSAGM
G
LM
P
G
H
VYRALYPCPLHGISEDDAIASIHRIFKN
D
AAPEDI
AAI
V
I
EPV
-
QG
E
GG
FYAAS
P
A
F
M
QR
LR
A
LCDE
H
GI
M
LI
A
DEV
QS
G
AG
RTG
T
LFA
MEQMGVA
PDL
T
T
F
AK
S
I
A
GG
-
F
PL
A
G
VT
G
R
AEVM
D
A
VA
PG
G
--
---L
G
G
T
YA
GNP
I
A
C
V
AA
L
E
V
L
KVFEQENLL
Q
KANDLGQ
K
L
K
D
G
L
LA
I
A
E
KHPEIG
DVRGLG
fig|358709.5.peg.4191
Escherichia coli 101-1 (22-352/426)
I
H
PI
F
A
D
-
---
--R
AE
N
CR
V
W
D
V
EG
RE
Y
L
D
FAG
GI
AVLNT
GH
L
HP
K
V
V
AAV
-
E
A
Q
LKKLS
H
TCFQVLAY
E
PY
L
E
L
C
E
I
M
NQKV
P
GDFAKK
T
LLVT
T
GSEA
V
E
N
A
V
K
I
AR
AATK-----
-
R
SGT
I
A
F
S
G
A
YHG
R
T
--------
HY
T
LA
L
TGKVNP
-
YSAGM
G
LM
P
G
H
VYRALYPCPLHGISEDDAIASIHRIFKN
D
AAPEDI
AAI
V
I
EPV
-
QG
E
GG
FYAAS
P
A
F
M
QR
LR
A
LCDE
H
GI
M
LI
A
DEV
QS
G
AG
RTG
T
LFA
MEQMGVA
PDL
T
T
F
AK
S
I
A
GG
-
F
PL
A
G
VT
G
R
AEVM
D
A
VA
PG
G
--
---L
G
G
T
YA
GNP
I
A
C
V
AA
L
E
V
L
KVFEQENLL
Q
KANDLGQ
K
L
K
D
G
L
LA
I
A
E
KHPEIG
DVRGLG
fig|585055.6.peg.2960
Escherichia coli 55989 (22-352/426)
I
H
PI
F
A
D
-
---
--R
AE
N
CR
V
W
D
V
EG
RE
Y
L
D
FAG
GI
AVLNT
GH
L
HP
K
V
V
AAV
-
E
A
Q
LKKLS
H
TCFQVLAY
E
PY
L
E
L
C
E
I
M
NQKV
P
GDFAKK
T
LLVT
T
GSEA
V
E
N
A
V
K
I
AR
AATK-----
-
R
SGT
I
A
F
S
G
A
YHG
R
T
--------
HY
T
LA
L
TGKVNP
-
YSAGM
G
LM
P
G
H
VYRALYPCPLHGISEDDAIASIHRIFKN
D
AAPEDI
AAI
V
I
EPV
-
QG
E
GG
FYAAS
P
A
F
M
QR
LR
A
LCDE
H
GI
M
LI
A
DEV
QS
G
AG
RTG
T
LFA
MEQMGVA
PDL
T
T
F
AK
S
I
A
GG
-
F
PL
A
G
VT
G
R
AEVM
D
A
VA
PG
G
--
---L
G
G
T
YA
GNP
I
A
C
V
AA
L
E
V
L
KVFEQENLL
Q
KANDLGQ
K
L
K
D
G
L
LA
I
A
E
KHPEIG
DVRGLG
fig|585055.8.peg.2964
Escherichia coli 55989 (22-352/426)
I
H
PI
F
A
D
-
---
--R
AE
N
CR
V
W
D
V
EG
RE
Y
L
D
FAG
GI
AVLNT
GH
L
HP
K
V
V
AAV
-
E
A
Q
LKKLS
H
TCFQVLAY
E
PY
L
E
L
C
E
I
M
NQKV
P
GDFAKK
T
LLVT
T
GSEA
V
E
N
A
V
K
I
AR
AATK-----
-
R
SGT
I
A
F
S
G
A
YHG
R
T
--------
HY
T
LA
L
TGKVNP
-
YSAGM
G
LM
P
G
H
VYRALYPCPLHGISEDDAIASIHRIFKN
D
AAPEDI
AAI
V
I
EPV
-
QG
E
GG
FYAAS
P
A
F
M
QR
LR
A
LCDE
H
GI
M
LI
A
DEV
QS
G
AG
RTG
T
LFA
MEQMGVA
PDL
T
T
F
AK
S
I
A
GG
-
F
PL
A
G
VT
G
R
AEVM
D
A
VA
PG
G
--
---L
G
G
T
YA
GNP
I
A
C
V
AA
L
E
V
L
KVFEQENLL
Q
KANDLGQ
K
L
K
D
G
L
LA
I
A
E
KHPEIG
DVRGLG
fig|413997.3.peg.2638
Escherichia coli B str. REL606 (22-352/426)
I
H
PI
F
A
D
-
---
--R
AE
N
CR
V
W
D
V
EG
RE
Y
L
D
FAG
GI
AVLNT
GH
L
HP
K
V
V
AAV
-
E
A
Q
LKKLS
H
TCFQVLAY
E
PY
L
E
L
C
E
I
M
NQKV
P
GDFAKK
T
LLVT
T
GSEA
V
E
N
A
V
K
I
AR
AATK-----
-
R
SGT
I
A
F
S
G
A
YHG
R
T
--------
HY
T
LA
L
TGKVNP
-
YSAGM
G
LM
P
G
H
VYRALYPCPLHGISEDDAIASIHRIFKN
D
AAPEDI
AAI
V
I
EPV
-
QG
E
GG
FYAAS
P
A
F
M
QR
LR
A
LCDE
H
GI
M
LI
A
DEV
QS
G
AG
RTG
T
LFA
MEQMGVA
PDL
T
T
F
AK
S
I
A
GG
-
F
PL
A
G
VT
G
R
AEVM
D
A
VA
PG
G
--
---L
G
G
T
YA
GNP
I
A
C
V
AA
L
E
V
L
KVFEQENLL
Q
KANDLGQ
K
L
K
D
G
L
LA
I
A
E
KHPEIG
DVRGLG
fig|550672.3.peg.2865
Escherichia coli B088 (22-352/426)
I
H
PI
F
A
D
-
---
--R
AE
N
CR
V
W
D
V
EG
RE
Y
L
D
FAG
GI
AVLNT
GH
L
HP
K
V
V
AAV
-
E
A
Q
LKKLS
H
TCFQVLAY
E
PY
L
E
L
C
E
I
M
NQKV
P
GDFAKK
T
LLVT
T
GSEA
V
E
N
A
V
K
I
AR
AATK-----
-
R
SGT
I
A
F
S
G
A
YHG
R
T
--------
HY
T
LA
L
TGKVNP
-
YSAGM
G
LM
P
G
H
VYRALYPCPLHGISEDDAIASIHRIFKN
D
AAPEDI
AAI
V
I
EPV
-
QG
E
GG
FYAAS
P
A
F
M
QR
LR
A
LCDE
H
GI
M
LI
A
DEV
QS
G
AG
RTG
T
LFA
MEQMGVA
PDL
T
T
F
AK
S
I
A
GG
-
F
PL
A
G
VT
G
R
AEVM
D
A
VA
PG
G
--
---L
G
G
T
YA
GNP
I
A
C
V
AA
L
E
V
L
KVFEQENLL
Q
KANDLGQ
K
L
K
D
G
L
LA
I
A
E
KHPEIG
DVRGLG
fig|511693.5.peg.2654
Escherichia coli BL21 (22-352/426)
I
H
PI
F
A
D
-
---
--R
AE
N
CR
V
W
D
V
EG
RE
Y
L
D
FAG
GI
AVLNT
GH
L
HP
K
V
V
AAV
-
E
A
Q
LKKLS
H
TCFQVLAY
E
PY
L
E
L
C
E
I
M
NQKV
P
GDFAKK
T
LLVT
T
GSEA
V
E
N
A
V
K
I
AR
AATK-----
-
R
SGT
I
A
F
S
G
A
YHG
R
T
--------
HY
T
LA
L
TGKVNP
-
YSAGM
G
LM
P
G
H
VYRALYPCPLHGISEDDAIASIHRIFKN
D
AAPEDI
AAI
V
I
EPV
-
QG
E
GG
FYAAS
P
A
F
M
QR
LR
A
LCDE
H
GI
M
LI
A
DEV
QS
G
AG
RTG
T
LFA
MEQMGVA
PDL
T
T
F
AK
S
I
A
GG
-
F
PL
A
G
VT
G
R
AEVM
D
A
VA
PG
G
--
---L
G
G
T
YA
GNP
I
A
C
V
AA
L
E
V
L
KVFEQENLL
Q
KANDLGQ
K
L
K
D
G
L
LA
I
A
E
KHPEIG
DVRGLG
fig|469008.4.peg.1084
Escherichia coli BL21(DE3) (22-352/426)
I
H
PI
F
A
D
-
---
--R
AE
N
CR
V
W
D
V
EG
RE
Y
L
D
FAG
GI
AVLNT
GH
L
HP
K
V
V
AAV
-
E
A
Q
LKKLS
H
TCFQVLAY
E
PY
L
E
L
C
E
I
M
NQKV
P
GDFAKK
T
LLVT
T
GSEA
V
E
N
A
V
K
I
AR
AATK-----
-
R
SGT
I
A
F
S
G
A
YHG
R
T
--------
HY
T
LA
L
TGKVNP
-
YSAGM
G
LM
P
G
H
VYRALYPCPLHGISEDDAIASIHRIFKN
D
AAPEDI
AAI
V
I
EPV
-
QG
E
GG
FYAAS
P
A
F
M
QR
LR
A
LCDE
H
GI
M
LI
A
DEV
QS
G
AG
RTG
T
LFA
MEQMGVA
PDL
T
T
F
AK
S
I
A
GG
-
F
PL
A
G
VT
G
R
AEVM
D
A
VA
PG
G
--
---L
G
G
T
YA
GNP
I
A
C
V
AA
L
E
V
L
KVFEQENLL
Q
KANDLGQ
K
L
K
D
G
L
LA
I
A
E
KHPEIG
DVRGLG
fig|340186.3.peg.4246
Escherichia coli E110019 (22-352/426)
I
H
PI
F
A
D
-
---
--R
AE
N
CR
V
W
D
V
EG
RE
Y
L
D
FAG
GI
AVLNT
GH
L
HP
K
V
V
AAV
-
E
A
Q
LKKLS
H
TCFQVLAY
E
PY
L
E
L
C
E
I
M
NQKV
P
GDFAKK
T
LLVT
T
GSEA
V
E
N
A
V
K
I
AR
AATK-----
-
R
SGT
I
A
F
S
G
A
YHG
R
T
--------
HY
T
LA
L
TGKVNP
-
YSAGM
G
LM
P
G
H
VYRALYPCPLHGISEDDAIASIHRIFKN
D
AAPEDI
AAI
V
I
EPV
-
QG
E
GG
FYAAS
P
A
F
M
QR
LR
A
LCDE
H
GI
M
LI
A
DEV
QS
G
AG
RTG
T
LFA
MEQMGVA
PDL
T
T
F
AK
S
I
A
GG
-
F
PL
A
G
VT
G
R
AEVM
D
A
VA
PG
G
--
---L
G
G
T
YA
GNP
I
A
C
V
AA
L
E
V
L
KVFEQENLL
Q
KANDLGQ
K
L
K
D
G
L
LA
I
A
E
KHPEIG
DVRGLG
fig|340186.5.peg.4464
Escherichia coli E110019 (22-352/426)
I
H
PI
F
A
D
-
---
--R
AE
N
CR
V
W
D
V
EG
RE
Y
L
D
FAG
GI
AVLNT
GH
L
HP
K
V
V
AAV
-
E
A
Q
LKKLS
H
TCFQVLAY
E
PY
L
E
L
C
E
I
M
NQKV
P
GDFAKK
T
LLVT
T
GSEA
V
E
N
A
V
K
I
AR
AATK-----
-
R
SGT
I
A
F
S
G
A
YHG
R
T
--------
HY
T
LA
L
TGKVNP
-
YSAGM
G
LM
P
G
H
VYRALYPCPLHGISEDDAIASIHRIFKN
D
AAPEDI
AAI
V
I
EPV
-
QG
E
GG
FYAAS
P
A
F
M
QR
LR
A
LCDE
H
GI
M
LI
A
DEV
QS
G
AG
RTG
T
LFA
MEQMGVA
PDL
T
T
F
AK
S
I
A
GG
-
F
PL
A
G
VT
G
R
AEVM
D
A
VA
PG
G
--
---L
G
G
T
YA
GNP
I
A
C
V
AA
L
E
V
L
KVFEQENLL
Q
KANDLGQ
K
L
K
D
G
L
LA
I
A
E
KHPEIG
DVRGLG
fig|562.375.peg.983
Escherichia coli EC4100B (22-352/426)
I
H
PI
F
A
D
-
---
--R
AE
N
CR
V
W
D
V
EG
RE
Y
L
D
FAG
GI
AVLNT
GH
L
HP
K
V
V
AAV
-
E
A
Q
LKKLS
H
TCFQVLAY
E
PY
L
E
L
C
E
I
M
NQKV
P
GDFAKK
T
LLVT
T
GSEA
V
E
N
A
V
K
I
AR
AATK-----
-
R
SGT
I
A
F
S
G
A
YHG
R
T
--------
HY
T
LA
L
TGKVNP
-
YSAGM
G
LM
P
G
H
VYRALYPCPLHGISEDDAIASIHRIFKN
D
AAPEDI
AAI
V
I
EPV
-
QG
E
GG
FYAAS
P
A
F
M
QR
LR
A
LCDE
H
GI
M
LI
A
DEV
QS
G
AG
RTG
T
LFA
MEQMGVA
PDL
T
T
F
AK
S
I
A
GG
-
F
PL
A
G
VT
G
R
AEVM
D
A
VA
PG
G
--
---L
G
G
T
YA
GNP
I
A
C
V
AA
L
E
V
L
KVFEQENLL
Q
KANDLGQ
K
L
K
D
G
L
LA
I
A
E
KHPEIG
DVRGLG
fig|656408.3.peg.2940
Escherichia coli H591 (22-352/426)
I
H
PI
F
A
D
-
---
--R
AE
N
CR
V
W
D
V
EG
RE
Y
L
D
FAG
GI
AVLNT
GH
L
HP
K
V
V
AAV
-
E
A
Q
LKKLS
H
TCFQVLAY
E
PY
L
E
L
C
E
I
M
NQKV
P
GDFAKK
T
LLVT
T
GSEA
V
E
N
A
V
K
I
AR
AATK-----
-
R
SGT
I
A
F
S
G
A
YHG
R
T
--------
HY
T
LA
L
TGKVNP
-
YSAGM
G
LM
P
G
H
VYRALYPCPLHGISEDDAIASIHRIFKN
D
AAPEDI
AAI
V
I
EPV
-
QG
E
GG
FYAAS
P
A
F
M
QR
LR
A
LCDE
H
GI
M
LI
A
DEV
QS
G
AG
RTG
T
LFA
MEQMGVA
PDL
T
T
F
AK
S
I
A
GG
-
F
PL
A
G
VT
G
R
AEVM
D
A
VA
PG
G
--
---L
G
G
T
YA
GNP
I
A
C
V
AA
L
E
V
L
KVFEQENLL
Q
KANDLGQ
K
L
K
D
G
L
LA
I
A
E
KHPEIG
DVRGLG
fig|585034.4.peg.2702
Escherichia coli IAI1 (22-352/426)
I
H
PI
F
A
D
-
---
--R
AE
N
CR
V
W
D
V
EG
RE
Y
L
D
FAG
GI
AVLNT
GH
L
HP
K
V
V
AAV
-
E
A
Q
LKKLS
H
TCFQVLAY
E
PY
L
E
L
C
E
I
M
NQKV
P
GDFAKK
T
LLVT
T
GSEA
V
E
N
A
V
K
I
AR
AATK-----
-
R
SGT
I
A
F
S
G
A
YHG
R
T
--------
HY
T
LA
L
TGKVNP
-
YSAGM
G
LM
P
G
H
VYRALYPCPLHGISEDDAIASIHRIFKN
D
AAPEDI
AAI
V
I
EPV
-
QG
E
GG
FYAAS
P
A
F
M
QR
LR
A
LCDE
H
GI
M
LI
A
DEV
QS
G
AG
RTG
T
LFA
MEQMGVA
PDL
T
T
F
AK
S
I
A
GG
-
F
PL
A
G
VT
G
R
AEVM
D
A
VA
PG
G
--
---L
G
G
T
YA
GNP
I
A
C
V
AA
L
E
V
L
KVFEQENLL
Q
KANDLGQ
K
L
K
D
G
L
LA
I
A
E
KHPEIG
DVRGLG
fig|585034.5.peg.2701
Escherichia coli IAI1 (22-352/426)
I
H
PI
F
A
D
-
---
--R
AE
N
CR
V
W
D
V
EG
RE
Y
L
D
FAG
GI
AVLNT
GH
L
HP
K
V
V
AAV
-
E
A
Q
LKKLS
H
TCFQVLAY
E
PY
L
E
L
C
E
I
M
NQKV
P
GDFAKK
T
LLVT
T
GSEA
V
E
N
A
V
K
I
AR
AATK-----
-
R
SGT
I
A
F
S
G
A
YHG
R
T
--------
HY
T
LA
L
TGKVNP
-
YSAGM
G
LM
P
G
H
VYRALYPCPLHGISEDDAIASIHRIFKN
D
AAPEDI
AAI
V
I
EPV
-
QG
E
GG
FYAAS
P
A
F
M
QR
LR
A
LCDE
H
GI
M
LI
A
DEV
QS
G
AG
RTG
T
LFA
MEQMGVA
PDL
T
T
F
AK
S
I
A
GG
-
F
PL
A
G
VT
G
R
AEVM
D
A
VA
PG
G
--
---L
G
G
T
YA
GNP
I
A
C
V
AA
L
E
V
L
KVFEQENLL
Q
KANDLGQ
K
L
K
D
G
L
LA
I
A
E
KHPEIG
DVRGLG
fig|679207.4.peg.941
Escherichia coli MS 107-1 (22-352/426)
I
H
PI
F
A
D
-
---
--R
AE
N
CR
V
W
D
V
EG
RE
Y
L
D
FAG
GI
AVLNT
GH
L
HP
K
V
V
AAV
-
E
A
Q
LKKLS
H
TCFQVLAY
E
PY
L
E
L
C
E
I
M
NQKV
P
GDFAKK
T
LLVT
T
GSEA
V
E
N
A
V
K
I
AR
AATK-----
-
R
SGT
I
A
F
S
G
A
YHG
R
T
--------
HY
T
LA
L
TGKVNP
-
YSAGM
G
LM
P
G
H
VYRALYPCPLHGISEDDAIASIHRIFKN
D
AAPEDI
AAI
V
I
EPV
-
QG
E
GG
FYAAS
P
A
F
M
QR
LR
A
LCDE
H
GI
M
LI
A
DEV
QS
G
AG
RTG
T
LFA
MEQMGVA
PDL
T
T
F
AK
S
I
A
GG
-
F
PL
A
G
VT
G
R
AEVM
D
A
VA
PG
G
--
---L
G
G
T
YA
GNP
I
A
C
V
AA
L
E
V
L
KVFEQENLL
Q
KANDLGQ
K
L
K
D
G
L
LA
I
A
E
KHPEIG
DVRGLG
fig|749547.3.peg.2698
Escherichia coli MS 187-1 (22-352/426)
I
H
PI
F
A
D
-
---
--R
AE
N
CR
V
W
D
V
EG
RE
Y
L
D
FAG
GI
AVLNT
GH
L
HP
K
V
V
AAV
-
E
A
Q
LKKLS
H
TCFQVLAY
E
PY
L
E
L
C
E
I
M
NQKV
P
GDFAKK
T
LLVT
T
GSEA
V
E
N
A
V
K
I
AR
AATK-----
-
R
SGT
I
A
F
S
G
A
YHG
R
T
--------
HY
T
LA
L
TGKVNP
-
YSAGM
G
LM
P
G
H
VYRALYPCPLHGISEDDAIASIHRIFKN
D
AAPEDI
AAI
V
I
EPV
-
QG
E
GG
FYAAS
P
A
F
M
QR
LR
A
LCDE
H
GI
M
LI
A
DEV
QS
G
AG
RTG
T
LFA
MEQMGVA
PDL
T
T
F
AK
S
I
A
GG
-
F
PL
A
G
VT
G
R
AEVM
D
A
VA
PG
G
--
---L
G
G
T
YA
GNP
I
A
C
V
AA
L
E
V
L
KVFEQENLL
Q
KANDLGQ
K
L
K
D
G
L
LA
I
A
E
KHPEIG
DVRGLG
fig|585396.4.peg.3491
Escherichia coli O111:H- str. 11128 (22-352/426)
I
H
PI
F
A
D
-
---
--R
AE
N
CR
V
W
D
V
EG
RE
Y
L
D
FAG
GI
AVLNT
GH
L
HP
K
V
V
AAV
-
E
A
Q
LKKLS
H
TCFQVLAY
E
PY
L
E
L
C
E
I
M
NQKV
P
GDFAKK
T
LLVT
T
GSEA
V
E
N
A
V
K
I
AR
AATK-----
-
R
SGT
I
A
F
S
G
A
YHG
R
T
--------
HY
T
LA
L
TGKVNP
-
YSAGM
G
LM
P
G
H
VYRALYPCPLHGISEDDAIASIHRIFKN
D
AAPEDI
AAI
V
I
EPV
-
QG
E
GG
FYAAS
P
A
F
M
QR
LR
A
LCDE
H
GI
M
LI
A
DEV
QS
G
AG
RTG
T
LFA
MEQMGVA
PDL
T
T
F
AK
S
I
A
GG
-
F
PL
A
G
VT
G
R
AEVM
D
A
VA
PG
G
--
---L
G
G
T
YA
GNP
I
A
C
V
AA
L
E
V
L
KVFEQENLL
Q
KANDLGQ
K
L
K
D
G
L
LA
I
A
E
KHPEIG
DVRGLG
fig|573235.3.peg.3803
Escherichia coli O26:H11 str. 11368 (22-352/426)
I
H
PI
F
A
D
-
---
--R
AE
N
CR
V
W
D
V
EG
RE
Y
L
D
FAG
GI
AVLNT
GH
L
HP
K
V
V
AAV
-
E
A
Q
LKKLS
H
TCFQVLAY
E
PY
L
E
L
C
E
I
M
NQKV
P
GDFAKK
T
LLVT
T
GSEA
V
E
N
A
V
K
I
AR
AATK-----
-
R
SGT
I
A
F
S
G
A
YHG
R
T
--------
HY
T
LA
L
TGKVNP
-
YSAGM
G
LM
P
G
H
VYRALYPCPLHGISEDDAIASIHRIFKN
D
AAPEDI
AAI
V
I
EPV
-
QG
E
GG
FYAAS
P
A
F
M
QR
LR
A
LCDE
H
GI
M
LI
A
DEV
QS
G
AG
RTG
T
LFA
MEQMGVA
PDL
T
T
F
AK
S
I
A
GG
-
F
PL
A
G
VT
G
R
AEVM
D
A
VA
PG
G
--
---L
G
G
T
YA
GNP
I
A
C
V
AA
L
E
V
L
KVFEQENLL
Q
KANDLGQ
K
L
K
D
G
L
LA
I
A
E
KHPEIG
DVRGLG
fig|670888.3.peg.3656
Escherichia coli 1827-70 (22-352/426)
I
H
PI
F
A
D
-
---
--R
AE
N
CR
V
W
D
V
EG
RE
Y
L
D
FAG
GI
AVLNT
GH
L
HP
K
V
V
AAV
-
E
A
Q
LKKLS
H
TCFQVLAY
E
PY
L
E
L
C
E
I
M
NQKV
P
GNFAKK
T
LLVT
T
GSEA
V
E
N
A
V
K
I
AR
AATK-----
-
R
SGT
I
A
F
S
G
A
YHG
R
T
--------
HY
T
LA
L
TGKVNP
-
YSAGM
G
LM
P
G
H
VYRALYPCPLHGISEDDAIASIHRIFKN
D
AAPEDI
AAI
V
I
EPV
-
QG
E
GG
FYASS
P
A
F
M
QR
LR
A
LCDE
H
GI
M
LI
A
DEV
QS
G
AG
RTG
T
LFA
MEQMGVA
PDL
T
T
F
AK
S
I
A
GG
-
F
PL
A
G
VT
G
R
AEVM
D
A
VA
PG
G
--
---L
G
G
T
YA
GNP
I
A
C
V
AA
L
E
V
L
KVFEQENLL
Q
KANDLGQ
K
L
K
D
G
L
LA
I
A
E
KHPEIG
DVRGLG
fig|344610.3.peg.2936
Escherichia coli 53638 (22-352/426)
I
H
PI
F
A
D
-
---
--R
AE
N
CR
V
W
D
V
EG
RE
Y
L
D
FAG
GI
AVLNT
GH
L
HP
K
V
V
AAV
-
E
A
Q
LKKLS
H
TCFQVLAY
E
PY
L
E
L
C
E
I
M
NQKV
P
GNFAKK
T
LLVT
T
GSEA
V
E
N
A
V
K
I
AR
AATK-----
-
R
SGT
I
A
F
S
G
A
YHG
R
T
--------
HY
T
LA
L
TGKVNP
-
YSAGM
G
LM
P
G
H
VYRALYPCPLHGISEDDAIASIHRIFKN
D
AAPEDI
AAI
V
I
EPV
-
QG
E
GG
FYASS
P
A
F
M
QR
LR
A
LCDE
H
GI
M
LI
A
DEV
QS
G
AG
RTG
T
LFA
MEQMGVA
PDL
T
T
F
AK
S
I
A
GG
-
F
PL
A
G
VT
G
R
AEVM
D
A
VA
PG
G
--
---L
G
G
T
YA
GNP
I
A
C
V
AA
L
E
V
L
KVFEQENLL
Q
KANDLGQ
K
L
K
D
G
L
LA
I
A
E
KHPEIG
DVRGLG
fig|344610.7.peg.3621
Escherichia coli 53638 (22-352/426)
I
H
PI
F
A
D
-
---
--R
AE
N
CR
V
W
D
V
EG
RE
Y
L
D
FAG
GI
AVLNT
GH
L
HP
K
V
V
AAV
-
E
A
Q
LKKLS
H
TCFQVLAY
E
PY
L
E
L
C
E
I
M
NQKV
P
GNFAKK
T
LLVT
T
GSEA
V
E
N
A
V
K
I
AR
AATK-----
-
R
SGT
I
A
F
S
G
A
YHG
R
T
--------
HY
T
LA
L
TGKVNP
-
YSAGM
G
LM
P
G
H
VYRALYPCPLHGISEDDAIASIHRIFKN
D
AAPEDI
AAI
V
I
EPV
-
QG
E
GG
FYASS
P
A
F
M
QR
LR
A
LCDE
H
GI
M
LI
A
DEV
QS
G
AG
RTG
T
LFA
MEQMGVA
PDL
T
T
F
AK
S
I
A
GG
-
F
PL
A
G
VT
G
R
AEVM
D
A
VA
PG
G
--
---L
G
G
T
YA
GNP
I
A
C
V
AA
L
E
V
L
KVFEQENLL
Q
KANDLGQ
K
L
K
D
G
L
LA
I
A
E
KHPEIG
DVRGLG
fig|481805.3.peg.1115
Escherichia coli ATCC 8739 (22-352/426)
I
H
PI
F
A
D
-
---
--R
AE
N
CR
V
W
D
V
EG
RE
Y
L
D
FAG
GI
AVLNT
GH
L
HP
K
V
V
AAV
-
E
A
Q
LKKLS
H
TCFQVLAY
E
PY
L
E
L
C
E
I
M
NQKV
P
GNFAKK
T
LLVT
T
GSEA
V
E
N
A
V
K
I
AR
AATK-----
-
R
SGT
I
A
F
S
G
A
YHG
R
T
--------
HY
T
LA
L
TGKVNP
-
YSAGM
G
LM
P
G
H
VYRALYPCPLHGISEDDAIASIHRIFKN
D
AAPEDI
AAI
V
I
EPV
-
QG
E
GG
FYASS
P
A
F
M
QR
LR
A
LCDE
H
GI
M
LI
A
DEV
QS
G
AG
RTG
T
LFA
MEQMGVA
PDL
T
T
F
AK
S
I
A
GG
-
F
PL
A
G
VT
G
R
AEVM
D
A
VA
PG
G
--
---L
G
G
T
YA
GNP
I
A
C
V
AA
L
E
V
L
KVFEQENLL
Q
KANDLGQ
K
L
K
D
G
L
LA
I
A
E
KHPEIG
DVRGLG
fig|481805.6.peg.1115
Escherichia coli ATCC 8739 (22-352/426)
I
H
PI
F
A
D
-
---
--R
AE
N
CR
V
W
D
V
EG
RE
Y
L
D
FAG
GI
AVLNT
GH
L
HP
K
V
V
AAV
-
E
A
Q
LKKLS
H
TCFQVLAY
E
PY
L
E
L
C
E
I
M
NQKV
P
GNFAKK
T
LLVT
T
GSEA
V
E
N
A
V
K
I
AR
AATK-----
-
R
SGT
I
A
F
S
G
A
YHG
R
T
--------
HY
T
LA
L
TGKVNP
-
YSAGM
G
LM
P
G
H
VYRALYPCPLHGISEDDAIASIHRIFKN
D
AAPEDI
AAI
V
I
EPV
-
QG
E
GG
FYASS
P
A
F
M
QR
LR
A
LCDE
H
GI
M
LI
A
DEV
QS
G
AG
RTG
T
LFA
MEQMGVA
PDL
T
T
F
AK
S
I
A
GG
-
F
PL
A
G
VT
G
R
AEVM
D
A
VA
PG
G
--
---L
G
G
T
YA
GNP
I
A
C
V
AA
L
E
V
L
KVFEQENLL
Q
KANDLGQ
K
L
K
D
G
L
LA
I
A
E
KHPEIG
DVRGLG
fig|344601.3.peg.2115
Escherichia coli B171 (22-352/426)
I
H
PI
F
A
D
-
---
--R
AE
N
CR
V
W
D
V
EG
RE
Y
L
D
FAG
GI
AVLNT
GH
L
HP
K
V
V
AAV
-
E
A
Q
LKKLS
H
TCFQVLAY
E
PY
L
E
L
C
E
I
M
NQKV
P
GNFAKK
T
LLVT
T
GSEA
V
E
N
A
V
K
I
AR
AATK-----
-
R
SGT
I
A
F
S
G
A
YHG
R
T
--------
HY
T
LA
L
TGKVNP
-
YSAGM
G
LM
P
G
H
VYRALYPCPLHGISEDDAIASIHRIFKN
D
AAPEDI
AAI
V
I
EPV
-
QG
E
GG
FYASS
P
A
F
M
QR
LR
A
LCDE
H
GI
M
LI
A
DEV
QS
G
AG
RTG
T
LFA
MEQMGVA
PDL
T
T
F
AK
S
I
A
GG
-
F
PL
A
G
VT
G
R
AEVM
D
A
VA
PG
G
--
---L
G
G
T
YA
GNP
I
A
C
V
AA
L
E
V
L
KVFEQENLL
Q
KANDLGQ
K
L
K
D
G
L
LA
I
A
E
KHPEIG
DVRGLG
fig|344601.5.peg.2208
Escherichia coli B171 (22-352/426)
I
H
PI
F
A
D
-
---
--R
AE
N
CR
V
W
D
V
EG
RE
Y
L
D
FAG
GI
AVLNT
GH
L
HP
K
V
V
AAV
-
E
A
Q
LKKLS
H
TCFQVLAY
E
PY
L
E
L
C
E
I
M
NQKV
P
GNFAKK
T
LLVT
T
GSEA
V
E
N
A
V
K
I
AR
AATK-----
-
R
SGT
I
A
F
S
G
A
YHG
R
T
--------
HY
T
LA
L
TGKVNP
-
YSAGM
G
LM
P
G
H
VYRALYPCPLHGISEDDAIASIHRIFKN
D
AAPEDI
AAI
V
I
EPV
-
QG
E
GG
FYASS
P
A
F
M
QR
LR
A
LCDE
H
GI
M
LI
A
DEV
QS
G
AG
RTG
T
LFA
MEQMGVA
PDL
T
T
F
AK
S
I
A
GG
-
F
PL
A
G
VT
G
R
AEVM
D
A
VA
PG
G
--
---L
G
G
T
YA
GNP
I
A
C
V
AA
L
E
V
L
KVFEQENLL
Q
KANDLGQ
K
L
K
D
G
L
LA
I
A
E
KHPEIG
DVRGLG
fig|340185.3.peg.4353
Escherichia coli E22 (22-352/426)
I
H
PI
F
A
D
-
---
--R
AE
N
CR
V
W
D
V
EG
RE
Y
L
D
FAG
GI
AVLNT
GH
L
HP
K
V
V
AAV
-
E
A
Q
LKKLS
H
TCFQVLAY
E
PY
L
E
L
C
E
I
M
NQKV
P
GNFAKK
T
LLVT
T
GSEA
V
E
N
A
V
K
I
AR
AATK-----
-
R
SGT
I
A
F
S
G
A
YHG
R
T
--------
HY
T
LA
L
TGKVNP
-
YSAGM
G
LM
P
G
H
VYRALYPCPLHGISEDDAIASIHRIFKN
D
AAPEDI
AAI
V
I
EPV
-
QG
E
GG
FYASS
P
A
F
M
QR
LR
A
LCDE
H
GI
M
LI
A
DEV
QS
G
AG
RTG
T
LFA
MEQMGVA
PDL
T
T
F
AK
S
I
A
GG
-
F
PL
A
G
VT
G
R
AEVM
D
A
VA
PG
G
--
---L
G
G
T
YA
GNP
I
A
C
V
AA
L
E
V
L
KVFEQENLL
Q
KANDLGQ
K
L
K
D
G
L
LA
I
A
E
KHPEIG
DVRGLG
fig|340185.4.peg.4593
Escherichia coli E22 (22-352/426)
I
H
PI
F
A
D
-
---
--R
AE
N
CR
V
W
D
V
EG
RE
Y
L
D
FAG
GI
AVLNT
GH
L
HP
K
V
V
AAV
-
E
A
Q
LKKLS
H
TCFQVLAY
E
PY
L
E
L
C
E
I
M
NQKV
P
GNFAKK
T
LLVT
T
GSEA
V
E
N
A
V
K
I
AR
AATK-----
-
R
SGT
I
A
F
S
G
A
YHG
R
T
--------
HY
T
LA
L
TGKVNP
-
YSAGM
G
LM
P
G
H
VYRALYPCPLHGISEDDAIASIHRIFKN
D
AAPEDI
AAI
V
I
EPV
-
QG
E
GG
FYASS
P
A
F
M
QR
LR
A
LCDE
H
GI
M
LI
A
DEV
QS
G
AG
RTG
T
LFA
MEQMGVA
PDL
T
T
F
AK
S
I
A
GG
-
F
PL
A
G
VT
G
R
AEVM
D
A
VA
PG
G
--
---L
G
G
T
YA
GNP
I
A
C
V
AA
L
E
V
L
KVFEQENLL
Q
KANDLGQ
K
L
K
D
G
L
LA
I
A
E
KHPEIG
DVRGLG
fig|331112.3.peg.2618
Escherichia coli HS (22-352/426)
I
H
PI
F
A
D
-
---
--R
AE
N
CR
V
W
D
V
EG
RE
Y
L
D
FAG
GI
AVLNT
GH
L
HP
K
V
V
AAV
-
E
A
Q
LKKLS
H
TCFQVLAY
E
PY
L
E
L
C
E
I
M
NQKV
P
GNFAKK
T
LLVT
T
GSEA
V
E
N
A
V
K
I
AR
AATK-----
-
R
SGT
I
A
F
S
G
A
YHG
R
T
--------
HY
T
LA
L
TGKVNP
-
YSAGM
G
LM
P
G
H
VYRALYPCPLHGISEDDAIASIHRIFKN
D
AAPEDI
AAI
V
I
EPV
-
QG
E
GG
FYASS
P
A
F
M
QR
LR
A
LCDE
H
GI
M
LI
A
DEV
QS
G
AG
RTG
T
LFA
MEQMGVA
PDL
T
T
F
AK
S
I
A
GG
-
F
PL
A
G
VT
G
R
AEVM
D
A
VA
PG
G
--
---L
G
G
T
YA
GNP
I
A
C
V
AA
L
E
V
L
KVFEQENLL
Q
KANDLGQ
K
L
K
D
G
L
LA
I
A
E
KHPEIG
DVRGLG
fig|331112.6.peg.2732
Escherichia coli HS (22-352/426)
I
H
PI
F
A
D
-
---
--R
AE
N
CR
V
W
D
V
EG
RE
Y
L
D
FAG
GI
AVLNT
GH
L
HP
K
V
V
AAV
-
E
A
Q
LKKLS
H
TCFQVLAY
E
PY
L
E
L
C
E
I
M
NQKV
P
GNFAKK
T
LLVT
T
GSEA
V
E
N
A
V
K
I
AR
AATK-----
-
R
SGT
I
A
F
S
G
A
YHG
R
T
--------
HY
T
LA
L
TGKVNP
-
YSAGM
G
LM
P
G
H
VYRALYPCPLHGISEDDAIASIHRIFKN
D
AAPEDI
AAI
V
I
EPV
-
QG
E
GG
FYASS
P
A
F
M
QR
LR
A
LCDE
H
GI
M
LI
A
DEV
QS
G
AG
RTG
T
LFA
MEQMGVA
PDL
T
T
F
AK
S
I
A
GG
-
F
PL
A
G
VT
G
R
AEVM
D
A
VA
PG
G
--
---L
G
G
T
YA
GNP
I
A
C
V
AA
L
E
V
L
KVFEQENLL
Q
KANDLGQ
K
L
K
D
G
L
LA
I
A
E
KHPEIG
DVRGLG
fig|749537.3.peg.635
Escherichia coli MS 115-1 (22-352/426)
I
H
PI
F
A
D
-
---
--R
AE
N
CR
V
W
D
V
EG
RE
Y
L
D
FAG
GI
AVLNT
GH
L
HP
K
V
V
AAV
-
E
A
Q
LKKLS
H
TCFQVLAY
E
PY
L
E
L
C
E
I
M
NQKV
P
GNFAKK
T
LLVT
T
GSEA
V
E
N
A
V
K
I
AR
AATK-----
-
R
SGT
I
A
F
S
G
A
YHG
R
T
--------
HY
T
LA
L
TGKVNP
-
YSAGM
G
LM
P
G
H
VYRALYPCPLHGISEDDAIASIHRIFKN
D
AAPEDI
AAI
V
I
EPV
-
QG
E
GG
FYASS
P
A
F
M
QR
LR
A
LCDE
H
GI
M
LI
A
DEV
QS
G
AG
RTG
T
LFA
MEQMGVA
PDL
T
T
F
AK
S
I
A
GG
-
F
PL
A
G
VT
G
R
AEVM
D
A
VA
PG
G
--
---L
G
G
T
YA
GNP
I
A
C
V
AA
L
E
V
L
KVFEQENLL
Q
KANDLGQ
K
L
K
D
G
L
LA
I
A
E
KHPEIG
DVRGLG
fig|585395.4.peg.3346
Escherichia coli O103:H2 str. 12009 (22-352/426)
I
H
PI
F
A
D
-
---
--R
AE
N
CR
V
W
D
V
EG
RE
Y
L
D
FAG
GI
AVLNT
GH
L
HP
K
V
V
AAV
-
E
A
Q
LKKLS
H
TCFQVLAY
E
PY
L
E
L
C
E
I
M
NQKV
P
GNFAKK
T
LLVT
T
GSEA
V
E
N
A
V
K
I
AR
AATK-----
-
R
SGT
I
A
F
S
G
A
YHG
R
T
--------
HY
T
LA
L
TGKVNP
-
YSAGM
G
LM
P
G
H
VYRALYPCPLHGISEDDAIASIHRIFKN
D
AAPEDI
AAI
V
I
EPV
-
QG
E
GG
FYASS
P
A
F
M
QR
LR
A
LCDE
H
GI
M
LI
A
DEV
QS
G
AG
RTG
T
LFA
MEQMGVA
PDL
T
T
F
AK
S
I
A
GG
-
F
PL
A
G
VT
G
R
AEVM
D
A
VA
PG
G
--
---L
G
G
T
YA
GNP
I
A
C
V
AA
L
E
V
L
KVFEQENLL
Q
KANDLGQ
K
L
K
D
G
L
LA
I
A
E
KHPEIG
DVRGLG
fig|679205.4.peg.4476
Escherichia coli MS 124-1 (22-352/426)
I
H
PI
F
A
D
-
---
--R
AE
N
CR
V
W
D
V
EG
RE
Y
L
D
FAG
GI
AVLNT
GH
L
HP
K
V
V
AAV
-
E
A
Q
LKKLS
H
TCFQVLAY
E
PY
L
E
L
C
E
I
M
NQKV
P
GNFAKK
T
LLVT
T
GSEA
V
E
N
A
V
K
I
AR
AATK-----
-
R
SGT
I
A
F
S
G
A
YHG
R
T
--------
HY
T
LA
L
TGKVNP
-
YSAGM
G
LM
P
G
H
VYRALYPCPLHGISEDDAIASIHRIFKN
D
AAPEDI
AAI
V
I
EPV
-
QG
E
GG
FYAAS
P
A
F
M
QR
LR
A
LCDE
H
GI
M
LI
A
DEV
QS
G
AG
RTG
T
LFA
MEQMGVA
PDL
T
T
F
AK
S
I
A
GG
-
F
PL
A
G
VT
G
R
AEVM
D
A
VA
PG
G
--
---L
G
G
T
YA
GNP
I
A
C
V
AA
L
E
V
L
KVFEQENLL
Q
KANDLGQ
K
L
K
D
G
L
LA
I
A
E
KHPEIG
DVRGLG
fig|749533.3.peg.4349
Escherichia coli MS 84-1 (22-352/426)
I
H
PI
F
A
D
-
---
--R
AE
N
CR
V
W
D
V
EG
RE
Y
L
D
FAG
GI
AVLNT
GH
L
HP
K
V
V
AAV
-
E
A
Q
LKKLS
H
TCFQVLAY
E
PY
L
E
L
C
E
I
M
NQKV
P
GNFAKK
T
LLVT
T
GSEA
V
E
N
A
V
K
I
AR
AATK-----
-
R
SGT
I
A
F
S
G
A
YHG
R
T
--------
HY
T
LA
L
TGKVNP
-
YSAGM
G
LM
P
G
H
VYRALYPCPLHGISEDDAIASIHRIFKN
D
AAPEDI
AAI
V
I
EPV
-
QG
E
GG
FYAAS
P
A
F
M
QR
LR
A
LCDE
H
GI
M
LI
A
DEV
QS
G
AG
RTG
T
LFA
MEQMGVA
PDL
T
T
F
AK
S
I
A
GG
-
F
PL
A
G
VT
G
R
AEVM
D
A
VA
PG
G
--
---L
G
G
T
YA
GNP
I
A
C
V
AA
L
E
V
L
KVFEQENLL
Q
KANDLGQ
K
L
K
D
G
L
LA
I
A
E
KHPEIG
DVRGLG
fig|405955.13.peg.2967
Escherichia coli APEC O1 (22-352/426)
I
H
PI
F
A
D
-
---
--R
AE
N
CR
V
W
D
V
EG
RE
Y
L
D
FAG
GI
AVLNT
GH
L
HP
K
V
V
AAV
-
E
A
Q
LKKLS
H
TCFQVLAY
E
PY
L
E
L
C
E
I
M
NQKV
P
GDFAKK
T
LLVT
T
GSEA
V
E
N
A
V
K
I
AR
AATK-----
-
R
SGT
I
A
F
S
G
A
YHG
R
T
--------
HY
T
LA
L
TGKVNP
-
YSAGM
G
LM
P
G
H
VYRALYPCPLHGISEDDAIASIHRIFKN
D
AAPEDI
AAI
V
I
EPV
-
QG
E
GG
FYAAT
P
A
F
M
QR
LR
A
LCDE
H
GI
M
LI
A
DEV
QS
G
AG
RTG
T
LFA
MEQMGVA
PDL
T
T
F
AK
S
I
A
GG
-
F
PL
A
G
VT
G
R
AEVM
D
A
VA
PG
G
--
---L
G
G
T
YA
GNP
I
A
C
V
AA
L
E
V
L
KVFEQENLL
Q
KANDLGQ
K
L
K
D
G
L
LA
I
A
E
KHTEIG
DVRGLG
fig|405955.9.peg.2448
Escherichia coli APEC O1 (22-352/426)
I
H
PI
F
A
D
-
---
--R
AE
N
CR
V
W
D
V
EG
RE
Y
L
D
FAG
GI
AVLNT
GH
L
HP
K
V
V
AAV
-
E
A
Q
LKKLS
H
TCFQVLAY
E
PY
L
E
L
C
E
I
M
NQKV
P
GDFAKK
T
LLVT
T
GSEA
V
E
N
A
V
K
I
AR
AATK-----
-
R
SGT
I
A
F
S
G
A
YHG
R
T
--------
HY
T
LA
L
TGKVNP
-
YSAGM
G
LM
P
G
H
VYRALYPCPLHGISEDDAIASIHRIFKN
D
AAPEDI
AAI
V
I
EPV
-
QG
E
GG
FYAAT
P
A
F
M
QR
LR
A
LCDE
H
GI
M
LI
A
DEV
QS
G
AG
RTG
T
LFA
MEQMGVA
PDL
T
T
F
AK
S
I
A
GG
-
F
PL
A
G
VT
G
R
AEVM
D
A
VA
PG
G
--
---L
G
G
T
YA
GNP
I
A
C
V
AA
L
E
V
L
KVFEQENLL
Q
KANDLGQ
K
L
K
D
G
L
LA
I
A
E
KHTEIG
DVRGLG
fig|656379.3.peg.4017
Escherichia coli FVEC1302 (22-352/426)
I
H
PI
F
A
D
-
---
--R
AE
N
CR
V
W
D
V
EG
RE
Y
L
D
FAG
GI
AVLNT
GH
L
HP
K
V
V
AAV
-
E
A
Q
LKKLS
H
TCFQVLAY
E
PY
L
E
L
C
E
I
M
NQKV
P
GDFAKK
T
LLVT
T
GSEA
V
E
N
A
V
K
I
AR
AATK-----
-
R
SGT
I
A
F
S
G
A
YHG
R
T
--------
HY
T
LA
L
TGKVNP
-
YSAGM
G
LM
P
G
H
VYRALYPCPLHGISEDDAIASIHRIFKN
D
AAPEDI
AAI
V
I
EPV
-
QG
E
GG
FYAAT
P
A
F
M
QR
LR
A
LCDE
H
GI
M
LI
A
DEV
QS
G
AG
RTG
T
LFA
MEQMGVA
PDL
T
T
F
AK
S
I
A
GG
-
F
PL
A
G
VT
G
R
AEVM
D
A
VA
PG
G
--
---L
G
G
T
YA
GNP
I
A
C
V
AA
L
E
V
L
KVFEQENLL
Q
KANDLGQ
K
L
K
D
G
L
LA
I
A
E
KHTEIG
DVRGLG
fig|656380.3.peg.3934
Escherichia coli FVEC1412 (22-352/426)
I
H
PI
F
A
D
-
---
--R
AE
N
CR
V
W
D
V
EG
RE
Y
L
D
FAG
GI
AVLNT
GH
L
HP
K
V
V
AAV
-
E
A
Q
LKKLS
H
TCFQVLAY
E
PY
L
E
L
C
E
I
M
NQKV
P
GDFAKK
T
LLVT
T
GSEA
V
E
N
A
V
K
I
AR
AATK-----
-
R
SGT
I
A
F
S
G
A
YHG
R
T
--------
HY
T
LA
L
TGKVNP
-
YSAGM
G
LM
P
G
H
VYRALYPCPLHGISEDDAIASIHRIFKN
D
AAPEDI
AAI
V
I
EPV
-
QG
E
GG
FYAAT
P
A
F
M
QR
LR
A
LCDE
H
GI
M
LI
A
DEV
QS
G
AG
RTG
T
LFA
MEQMGVA
PDL
T
T
F
AK
S
I
A
GG
-
F
PL
A
G
VT
G
R
AEVM
D
A
VA
PG
G
--
---L
G
G
T
YA
GNP
I
A
C
V
AA
L
E
V
L
KVFEQENLL
Q
KANDLGQ
K
L
K
D
G
L
LA
I
A
E
KHTEIG
DVRGLG
fig|714962.3.peg.3070
Escherichia coli IHE3034 (22-352/426)
I
H
PI
F
A
D
-
---
--R
AE
N
CR
V
W
D
V
EG
RE
Y
L
D
FAG
GI
AVLNT
GH
L
HP
K
V
V
AAV
-
E
A
Q
LKKLS
H
TCFQVLAY
E
PY
L
E
L
C
E
I
M
NQKV
P
GDFAKK
T
LLVT
T
GSEA
V
E
N
A
V
K
I
AR
AATK-----
-
R
SGT
I
A
F
S
G
A
YHG
R
T
--------
HY
T
LA
L
TGKVNP
-
YSAGM
G
LM
P
G
H
VYRALYPCPLHGISEDDAIASIHRIFKN
D
AAPEDI
AAI
V
I
EPV
-
QG
E
GG
FYAAT
P
A
F
M
QR
LR
A
LCDE
H
GI
M
LI
A
DEV
QS
G
AG
RTG
T
LFA
MEQMGVA
PDL
T
T
F
AK
S
I
A
GG
-
F
PL
A
G
VT
G
R
AEVM
D
A
VA
PG
G
--
---L
G
G
T
YA
GNP
I
A
C
V
AA
L
E
V
L
KVFEQENLL
Q
KANDLGQ
K
L
K
D
G
L
LA
I
A
E
KHTEIG
DVRGLG
fig|749549.3.peg.2628
Escherichia coli MS 198-1 (22-352/426)
I
H
PI
F
A
D
-
---
--R
AE
N
CR
V
W
D
V
EG
RE
Y
L
D
FAG
GI
AVLNT
GH
L
HP
K
V
V
AAV
-
E
A
Q
LKKLS
H
TCFQVLAY
E
PY
L
E
L
C
E
I
M
NQKV
P
GDFAKK
T
LLVT
T
GSEA
V
E
N
A
V
K
I
AR
AATK-----
-
R
SGT
I
A
F
S
G
A
YHG
R
T
--------
HY
T
LA
L
TGKVNP
-
YSAGM
G
LM
P
G
H
VYRALYPCPLHGISEDDAIASIHRIFKN
D
AAPEDI
AAI
V
I
EPV
-
QG
E
GG
FYAAT
P
A
F
M
QR
LR
A
LCDE
H
GI
M
LI
A
DEV
QS
G
AG
RTG
T
LFA
MEQMGVA
PDL
T
T
F
AK
S
I
A
GG
-
F
PL
A
G
VT
G
R
AEVM
D
A
VA
PG
G
--
---L
G
G
T
YA
GNP
I
A
C
V
AA
L
E
V
L
KVFEQENLL
Q
KANDLGQ
K
L
K
D
G
L
LA
I
A
E
KHTEIG
DVRGLG
fig|749531.3.peg.957
Escherichia coli MS 69-1 (22-352/426)
I
H
PI
F
A
D
-
---
--R
AE
N
CR
V
W
D
V
EG
RE
Y
L
D
FAG
GI
AVLNT
GH
L
HP
K
V
V
AAV
-
E
A
Q
LKKLS
H
TCFQVLAY
E
PY
L
E
L
C
E
I
M
NQKV
P
GDFAKK
T
LLVT
T
GSEA
V
E
N
A
V
K
I
AR
AATK-----
-
R
SGT
I
A
F
S
G
A
YHG
R
T
--------
HY
T
LA
L
TGKVNP
-
YSAGM
G
LM
P
G
H
VYRALYPCPLHGISEDDAIASIHRIFKN
D
AAPEDI
AAI
V
I
EPV
-
QG
E
GG
FYAAT
P
A
F
M
QR
LR
A
LCDE
H
GI
M
LI
A
DEV
QS
G
AG
RTG
T
LFA
MEQMGVA
PDL
T
T
F
AK
S
I
A
GG
-
F
PL
A
G
VT
G
R
AEVM
D
A
VA
PG
G
--
---L
G
G
T
YA
GNP
I
A
C
V
AA
L
E
V
L
KVFEQENLL
Q
KANDLGQ
K
L
K
D
G
L
LA
I
A
E
KHTEIG
DVRGLG
fig|753642.3.peg.500
Escherichia coli NC101 (22-352/426)
I
H
PI
F
A
D
-
---
--R
AE
N
CR
V
W
D
V
EG
RE
Y
L
D
FAG
GI
AVLNT
GH
L
HP
K
V
V
AAV
-
E
A
Q
LKKLS
H
TCFQVLAY
E
PY
L
E
L
C
E
I
M
NQKV
P
GDFAKK
T
LLVT
T
GSEA
V
E
N
A
V
K
I
AR
AATK-----
-
R
SGT
I
A
F
S
G
A
YHG
R
T
--------
HY
T
LA
L
TGKVNP
-
YSAGM
G
LM
P
G
H
VYRALYPCPLHGISEDDAIASIHRIFKN
D
AAPEDI
AAI
V
I
EPV
-
QG
E
GG
FYAAT
P
A
F
M
QR
LR
A
LCDE
H
GI
M
LI
A
DEV
QS
G
AG
RTG
T
LFA
MEQMGVA
PDL
T
T
F
AK
S
I
A
GG
-
F
PL
A
G
VT
G
R
AEVM
D
A
VA
PG
G
--
---L
G
G
T
YA
GNP
I
A
C
V
AA
L
E
V
L
KVFEQENLL
Q
KANDLGQ
K
L
K
D
G
L
LA
I
A
E
KHTEIG
DVRGLG
fig|685038.3.peg.2651
Escherichia coli O83:H1 str. NRG 857C (22-352/426)
I
H
PI
F
A
D
-
---
--R
AE
N
CR
V
W
D
V
EG
RE
Y
L
D
FAG
GI
AVLNT
GH
L
HP
K
V
V
AAV
-
E
A
Q
LKKLS
H
TCFQVLAY
E
PY
L
E
L
C
E
I
M
NQKV
P
GDFAKK
T
LLVT
T
GSEA
V
E
N
A
V
K
I
AR
AATK-----
-
R
SGT
I
A
F
S
G
A
YHG
R
T
--------
HY
T
LA
L
TGKVNP
-
YSAGM
G
LM
P
G
H
VYRALYPCPLHGISEDDAIASIHRIFKN
D
AAPEDI
AAI
V
I
EPV
-
QG
E
GG
FYAAT
P
A
F
M
QR
LR
A
LCDE
H
GI
M
LI
A
DEV
QS
G
AG
RTG
T
LFA
MEQMGVA
PDL
T
T
F
AK
S
I
A
GG
-
F
PL
A
G
VT
G
R
AEVM
D
A
VA
PG
G
--
---L
G
G
T
YA
GNP
I
A
C
V
AA
L
E
V
L
KVFEQENLL
Q
KANDLGQ
K
L
K
D
G
L
LA
I
A
E
KHTEIG
DVRGLG
fig|585035.6.peg.2868
Escherichia coli S88 (22-352/426)
I
H
PI
F
A
D
-
---
--R
AE
N
CR
V
W
D
V
EG
RE
Y
L
D
FAG
GI
AVLNT
GH
L
HP
K
V
V
AAV
-
E
A
Q
LKKLS
H
TCFQVLAY
E
PY
L
E
L
C
E
I
M
NQKV
P
GDFAKK
T
LLVT
T
GSEA
V
E
N
A
V
K
I
AR
AATK-----
-
R
SGT
I
A
F
S
G
A
YHG
R
T
--------
HY
T
LA
L
TGKVNP
-
YSAGM
G
LM
P
G
H
VYRALYPCPLHGISEDDAIASIHRIFKN
D
AAPEDI
AAI
V
I
EPV
-
QG
E
GG
FYAAT
P
A
F
M
QR
LR
A
LCDE
H
GI
M
LI
A
DEV
QS
G
AG
RTG
T
LFA
MEQMGVA
PDL
T
T
F
AK
S
I
A
GG
-
F
PL
A
G
VT
G
R
AEVM
D
A
VA
PG
G
--
---L
G
G
T
YA
GNP
I
A
C
V
AA
L
E
V
L
KVFEQENLL
Q
KANDLGQ
K
L
K
D
G
L
LA
I
A
E
KHTEIG
DVRGLG
fig|656437.3.peg.2980
Escherichia coli TA143 (22-352/426)
I
H
PI
F
A
D
-
---
--R
AE
N
CR
V
W
D
V
EG
RE
Y
L
D
FAG
GI
AVLNT
GH
L
HP
K
V
V
AAV
-
E
A
Q
LKKLS
H
TCFQVLAY
E
PY
L
E
L
C
E
I
M
NQKV
P
GDFAKK
T
LLVT
T
GSEA
V
E
N
A
V
K
I
AR
AATK-----
-
R
SGT
I
A
F
S
G
A
YHG
R
T
--------
HY
T
LA
L
TGKVNP
-
YSAGM
G
LM
P
G
H
VYRALYPCPLHGISEDDAIASIHRIFKN
D
AAPEDI
AAI
V
I
EPV
-
QG
E
GG
FYAAT
P
A
F
M
QR
LR
A
LCDE
H
GI
M
LI
A
DEV
QS
G
AG
RTG
T
LFA
MEQMGVA
PDL
T
T
F
AK
S
I
A
GG
-
F
PL
A
G
VT
G
R
AEVM
D
A
VA
PG
G
--
---L
G
G
T
YA
GNP
I
A
C
V
AA
L
E
V
L
KVFEQENLL
Q
KANDLGQ
K
L
K
D
G
L
LA
I
A
E
KHTEIG
DVRGLG
fig|869729.3.peg.711
Escherichia coli UM146 (22-352/426)
I
H
PI
F
A
D
-
---
--R
AE
N
CR
V
W
D
V
EG
RE
Y
L
D
FAG
GI
AVLNT
GH
L
HP
K
V
V
AAV
-
E
A
Q
LKKLS
H
TCFQVLAY
E
PY
L
E
L
C
E
I
M
NQKV
P
GDFAKK
T
LLVT
T
GSEA
V
E
N
A
V
K
I
AR
AATK-----
-
R
SGT
I
A
F
S
G
A
YHG
R
T
--------
HY
T
LA
L
TGKVNP
-
YSAGM
G
LM
P
G
H
VYRALYPCPLHGISEDDAIASIHRIFKN
D
AAPEDI
AAI
V
I
EPV
-
QG
E
GG
FYAAT
P
A
F
M
QR
LR
A
LCDE
H
GI
M
LI
A
DEV
QS
G
AG
RTG
T
LFA
MEQMGVA
PDL
T
T
F
AK
S
I
A
GG
-
F
PL
A
G
VT
G
R
AEVM
D
A
VA
PG
G
--
---L
G
G
T
YA
GNP
I
A
C
V
AA
L
E
V
L
KVFEQENLL
Q
KANDLGQ
K
L
K
D
G
L
LA
I
A
E
KHTEIG
DVRGLG
fig|585056.7.peg.3162
Escherichia coli UMN026 (22-352/426)
I
H
PI
F
A
D
-
---
--R
AE
N
CR
V
W
D
V
EG
RE
Y
L
D
FAG
GI
AVLNT
GH
L
HP
K
V
V
AAV
-
E
A
Q
LKKLS
H
TCFQVLAY
E
PY
L
E
L
C
E
I
M
NQKV
P
GDFAKK
T
LLVT
T
GSEA
V
E
N
A
V
K
I
AR
AATK-----
-
R
SGT
I
A
F
S
G
A
YHG
R
T
--------
HY
T
LA
L
TGKVNP
-
YSAGM
G
LM
P
G
H
VYRALYPCPLHGISEDDAIASIHRIFKN
D
AAPEDI
AAI
V
I
EPV
-
QG
E
GG
FYAAT
P
A
F
M
QR
LR
A
LCDE
H
GI
M
LI
A
DEV
QS
G
AG
RTG
T
LFA
MEQMGVA
PDL
T
T
F
AK
S
I
A
GG
-
F
PL
A
G
VT
G
R
AEVM
D
A
VA
PG
G
--
---L
G
G
T
YA
GNP
I
A
C
V
AA
L
E
V
L
KVFEQENLL
Q
KANDLGQ
K
L
K
D
G
L
LA
I
A
E
KHTEIG
DVRGLG
fig|364106.7.peg.3003
Escherichia coli UTI89 (22-352/426)
I
H
PI
F
A
D
-
---
--R
AE
N
CR
V
W
D
V
EG
RE
Y
L
D
FAG
GI
AVLNT
GH
L
HP
K
V
V
AAV
-
E
A
Q
LKKLS
H
TCFQVLAY
E
PY
L
E
L
C
E
I
M
NQKV
P
GDFAKK
T
LLVT
T
GSEA
V
E
N
A
V
K
I
AR
AATK-----
-
R
SGT
I
A
F
S
G
A
YHG
R
T
--------
HY
T
LA
L
TGKVNP
-
YSAGM
G
LM
P
G
H
VYRALYPCPLHGISEDDAIASIHRIFKN
D
AAPEDI
AAI
V
I
EPV
-
QG
E
GG
FYAAT
P
A
F
M
QR
LR
A
LCDE
H
GI
M
LI
A
DEV
QS
G
AG
RTG
T
LFA
MEQMGVA
PDL
T
T
F
AK
S
I
A
GG
-
F
PL
A
G
VT
G
R
AEVM
D
A
VA
PG
G
--
---L
G
G
T
YA
GNP
I
A
C
V
AA
L
E
V
L
KVFEQENLL
Q
KANDLGQ
K
L
K
D
G
L
LA
I
A
E
KHTEIG
DVRGLG
fig|364106.8.peg.3004
Escherichia coli UTI89 (22-352/426)
I
H
PI
F
A
D
-
---
--R
AE
N
CR
V
W
D
V
EG
RE
Y
L
D
FAG
GI
AVLNT
GH
L
HP
K
V
V
AAV
-
E
A
Q
LKKLS
H
TCFQVLAY
E
PY
L
E
L
C
E
I
M
NQKV
P
GDFAKK
T
LLVT
T
GSEA
V
E
N
A
V
K
I
AR
AATK-----
-
R
SGT
I
A
F
S
G
A
YHG
R
T
--------
HY
T
LA
L
TGKVNP
-
YSAGM
G
LM
P
G
H
VYRALYPCPLHGISEDDAIASIHRIFKN
D
AAPEDI
AAI
V
I
EPV
-
QG
E
GG
FYAAT
P
A
F
M
QR
LR
A
LCDE
H
GI
M
LI
A
DEV
QS
G
AG
RTG
T
LFA
MEQMGVA
PDL
T
T
F
AK
S
I
A
GG
-
F
PL
A
G
VT
G
R
AEVM
D
A
VA
PG
G
--
---L
G
G
T
YA
GNP
I
A
C
V
AA
L
E
V
L
KVFEQENLL
Q
KANDLGQ
K
L
K
D
G
L
LA
I
A
E
KHTEIG
DVRGLG
fig|585397.7.peg.3119
Escherichia coli ED1a (22-352/426)
I
H
PI
F
A
D
-
---
--R
AE
N
CR
V
W
D
V
EG
RE
Y
L
D
FAG
GI
AVLNT
GH
L
HP
K
V
V
AAV
-
E
A
Q
LKKLS
H
TCFQVLAY
E
PY
L
E
L
C
E
I
M
NQKV
P
GDFAKK
T
LLVT
T
GSEA
V
E
N
A
V
K
I
AR
AATK-----
-
R
SGT
I
A
F
S
G
A
YHG
R
T
--------
HY
T
LA
L
TGKVNP
-
YSAGM
G
LM
P
G
H
VYRALYPCPLHGISEDDAIASIHRIFKN
D
AAPEDI
AAI
V
I
EPV
-
QG
E
GG
FYAAT
P
A
F
M
LR
LR
A
LCDE
H
GI
M
LI
A
DEV
QS
G
AG
RTG
T
LFA
MEQMGVA
PDL
T
T
F
AK
S
I
A
GG
-
F
PL
A
G
VT
G
R
AEVM
D
A
VA
PG
G
--
---L
G
G
T
YA
GNP
I
A
C
V
AA
L
E
V
L
KVFEQENLL
Q
KANVLGQ
K
L
K
D
G
L
LA
I
A
K
KHPEIG
DVRGLG
fig|585397.9.peg.3115
Escherichia coli ED1a (22-352/426)
I
H
PI
F
A
D
-
---
--R
AE
N
CR
V
W
D
V
EG
RE
Y
L
D
FAG
GI
AVLNT
GH
L
HP
K
V
V
AAV
-
E
A
Q
LKKLS
H
TCFQVLAY
E
PY
L
E
L
C
E
I
M
NQKV
P
GDFAKK
T
LLVT
T
GSEA
V
E
N
A
V
K
I
AR
AATK-----
-
R
SGT
I
A
F
S
G
A
YHG
R
T
--------
HY
T
LA
L
TGKVNP
-
YSAGM
G
LM
P
G
H
VYRALYPCPLHGISEDDAIASIHRIFKN
D
AAPEDI
AAI
V
I
EPV
-
QG
E
GG
FYAAT
P
A
F
M
LR
LR
A
LCDE
H
GI
M
LI
A
DEV
QS
G
AG
RTG
T
LFA
MEQMGVA
PDL
T
T
F
AK
S
I
A
GG
-
F
PL
A
G
VT
G
R
AEVM
D
A
VA
PG
G
--
---L
G
G
T
YA
GNP
I
A
C
V
AA
L
E
V
L
KVFEQENLL
Q
KANVLGQ
K
L
K
D
G
L
LA
I
A
K
KHPEIG
DVRGLG
fig|216592.1.peg.3438
Escherichia coli 042 (22-352/426)
I
H
PI
F
A
D
-
---
--R
AE
N
CR
V
W
D
V
EG
RE
Y
L
D
FAG
GI
AVLNT
GH
L
HP
K
V
V
AAV
-
E
A
Q
LKKLS
H
TCFQVLAY
E
PY
L
E
L
C
E
I
M
NQKV
P
GDFAKK
T
LLVT
T
GSEA
V
E
N
A
V
K
I
AR
AATK-----
-
R
SGT
I
A
F
S
G
A
YHG
R
T
--------
HY
T
LA
L
TGKVNP
-
YSAGM
G
LM
P
G
H
VYRALYPCPLHGISEDDAIASIHRIFKN
D
AAPEDI
AAI
V
I
EPV
-
QG
E
GG
FYAAT
P
A
F
M
QR
LR
A
LCDE
H
GI
M
LI
A
DEV
QS
G
AG
RTG
T
LFA
MEQMGVA
PDL
T
T
F
AK
S
I
A
GG
-
F
PL
A
G
VT
G
R
AEVM
D
A
VA
PG
G
--
---L
G
G
T
YA
GNP
I
A
C
V
AA
L
E
V
L
KVFEQENLL
Q
KANDLGQ
K
L
K
D
G
L
LA
I
A
E
KHPEIG
DVRGLG
fig|216592.3.peg.2988
Escherichia coli 042 (22-352/426)
I
H
PI
F
A
D
-
---
--R
AE
N
CR
V
W
D
V
EG
RE
Y
L
D
FAG
GI
AVLNT
GH
L
HP
K
V
V
AAV
-
E
A
Q
LKKLS
H
TCFQVLAY
E
PY
L
E
L
C
E
I
M
NQKV
P
GDFAKK
T
LLVT
T
GSEA
V
E
N
A
V
K
I
AR
AATK-----
-
R
SGT
I
A
F
S
G
A
YHG
R
T
--------
HY
T
LA
L
TGKVNP
-
YSAGM
G
LM
P
G
H
VYRALYPCPLHGISEDDAIASIHRIFKN
D
AAPEDI
AAI
V
I
EPV
-
QG
E
GG
FYAAT
P
A
F
M
QR
LR
A
LCDE
H
GI
M
LI
A
DEV
QS
G
AG
RTG
T
LFA
MEQMGVA
PDL
T
T
F
AK
S
I
A
GG
-
F
PL
A
G
VT
G
R
AEVM
D
A
VA
PG
G
--
---L
G
G
T
YA
GNP
I
A
C
V
AA
L
E
V
L
KVFEQENLL
Q
KANDLGQ
K
L
K
D
G
L
LA
I
A
E
KHPEIG
DVRGLG
fig|562.371.peg.426
Escherichia coli 1044A (22-352/426)
I
H
PI
F
A
D
-
---
--R
AE
N
CR
V
W
D
V
EG
RE
Y
L
D
FAG
GI
AVLNT
GH
L
HP
K
V
V
AAV
-
E
A
Q
LKKLS
H
TCFQVLAY
E
PY
L
E
L
C
E
I
M
NQKV
P
GDFAKK
T
LLVT
T
GSEA
V
E
N
A
V
K
I
AR
AATK-----
-
R
SGT
I
A
F
S
G
A
YHG
R
T
--------
HY
T
LA
L
TGKVNP
-
YSAGM
G
LM
P
G
H
VYRALYPCPLHGISEDDAIASIHRIFKN
D
AAPEDI
AAI
V
I
EPV
-
QG
E
GG
FYAAT
P
A
F
M
QR
LR
A
LCDE
H
GI
M
LI
A
DEV
QS
G
AG
RTG
T
LFA
MEQMGVA
PDL
T
T
F
AK
S
I
A
GG
-
F
PL
A
G
VT
G
R
AEVM
D
A
VA
PG
G
--
---L
G
G
T
YA
GNP
I
A
C
V
AA
L
E
V
L
KVFEQENLL
Q
KANDLGQ
K
L
K
D
G
L
LA
I
A
E
KHPEIG
DVRGLG
fig|562.373.peg.4155
Escherichia coli 1125A (22-352/426)
I
H
PI
F
A
D
-
---
--R
AE
N
CR
V
W
D
V
EG
RE
Y
L
D
FAG
GI
AVLNT
GH
L
HP
K
V
V
AAV
-
E
A
Q
LKKLS
H
TCFQVLAY
E
PY
L
E
L
C
E
I
M
NQKV
P
GDFAKK
T
LLVT
T
GSEA
V
E
N
A
V
K
I
AR
AATK-----
-
R
SGT
I
A
F
S
G
A
YHG
R
T
--------
HY
T
LA
L
TGKVNP
-
YSAGM
G
LM
P
G
H
VYRALYPCPLHGISEDDAIASIHRIFKN
D
AAPEDI
AAI
V
I
EPV
-
QG
E
GG
FYAAT
P
A
F
M
QR
LR
A
LCDE
H
GI
M
LI
A
DEV
QS
G
AG
RTG
T
LFA
MEQMGVA
PDL
T
T
F
AK
S
I
A
GG
-
F
PL
A
G
VT
G
R
AEVM
D
A
VA
PG
G
--
---L
G
G
T
YA
GNP
I
A
C
V
AA
L
E
V
L
KVFEQENLL
Q
KANDLGQ
K
L
K
D
G
L
LA
I
A
E
KHPEIG
DVRGLG
fig|562.372.peg.2084
Escherichia coli 1212A (22-352/426)
I
H
PI
F
A
D
-
---
--R
AE
N
CR
V
W
D
V
EG
RE
Y
L
D
FAG
GI
AVLNT
GH
L
HP
K
V
V
AAV
-
E
A
Q
LKKLS
H
TCFQVLAY
E
PY
L
E
L
C
E
I
M
NQKV
P
GDFAKK
T
LLVT
T
GSEA
V
E
N
A
V
K
I
AR
AATK-----
-
R
SGT
I
A
F
S
G
A
YHG
R
T
--------
HY
T
LA
L
TGKVNP
-
YSAGM
G
LM
P
G
H
VYRALYPCPLHGISEDDAIASIHRIFKN
D
AAPEDI
AAI
V
I
EPV
-
QG
E
GG
FYAAT
P
A
F
M
QR
LR
A
LCDE
H
GI
M
LI
A
DEV
QS
G
AG
RTG
T
LFA
MEQMGVA
PDL
T
T
F
AK
S
I
A
GG
-
F
PL
A
G
VT
G
R
AEVM
D
A
VA
PG
G
--
---L
G
G
T
YA
GNP
I
A
C
V
AA
L
E
V
L
KVFEQENLL
Q
KANDLGQ
K
L
K
D
G
L
LA
I
A
E
KHPEIG
DVRGLG
fig|562.374.peg.4038
Escherichia coli 536A (22-352/426)
I
H
PI
F
A
D
-
---
--R
AE
N
CR
V
W
D
V
EG
RE
Y
L
D
FAG
GI
AVLNT
GH
L
HP
K
V
V
AAV
-
E
A
Q
LKKLS
H
TCFQVLAY
E
PY
L
E
L
C
E
I
M
NQKV
P
GDFAKK
T
LLVT
T
GSEA
V
E
N
A
V
K
I
AR
AATK-----
-
R
SGT
I
A
F
S
G
A
YHG
R
T
--------
HY
T
LA
L
TGKVNP
-
YSAGM
G
LM
P
G
H
VYRALYPCPLHGISEDDAIASIHRIFKN
D
AAPEDI
AAI
V
I
EPV
-
QG
E
GG
FYAAT
P
A
F
M
QR
LR
A
LCDE
H
GI
M
LI
A
DEV
QS
G
AG
RTG
T
LFA
MEQMGVA
PDL
T
T
F
AK
S
I
A
GG
-
F
PL
A
G
VT
G
R
AEVM
D
A
VA
PG
G
--
---L
G
G
T
YA
GNP
I
A
C
V
AA
L
E
V
L
KVFEQENLL
Q
KANDLGQ
K
L
K
D
G
L
LA
I
A
E
KHPEIG
DVRGLG
fig|595495.4.peg.4713
Escherichia coli KO11 (22-352/426)
I
H
PI
F
A
D
-
---
--R
AE
N
CR
V
W
D
V
EG
RE
Y
L
D
FAG
GI
AVLNT
GH
L
HP
K
V
V
AAV
-
E
A
Q
LKKLS
H
TCFQVLAY
E
PY
L
E
L
C
E
I
M
NQKV
P
GDFAKK
T
LLVT
T
GSEA
V
E
N
A
V
K
I
AR
AATK-----
-
R
SGT
I
A
F
S
G
A
YHG
R
T
--------
HY
T
LA
L
TGKVNP
-
YSAGM
G
LM
P
G
H
VYRALYPCPLHGISEDDAIASIHRIFKN
D
AAPEDI
AAI
V
I
EPV
-
QG
E
GG
FYAAT
P
A
F
M
QR
LR
A
LCDE
H
GI
M
LI
A
DEV
QS
G
AG
RTG
T
LFA
MEQMGVA
PDL
T
T
F
AK
S
I
A
GG
-
F
PL
A
G
VT
G
R
AEVM
D
A
VA
PG
G
--
---L
G
G
T
YA
GNP
I
A
C
V
AA
L
E
V
L
KVFEQENLL
Q
KANDLGQ
K
L
K
D
G
L
LA
I
A
E
KHPEIG
DVRGLG
fig|656419.3.peg.3479
Escherichia coli M718 (22-352/426)
I
H
PI
F
A
D
-
---
--R
AE
N
CR
V
W
D
V
EG
RE
Y
L
D
FAG
GI
AVLNT
GH
L
HP
K
V
V
AAV
-
E
A
Q
LKKLS
H
TCFQVLAY
E
PY
L
E
L
C
E
I
M
NQKV
P
GDFAKK
T
LLVT
T
GSEA
V
E
N
A
V
K
I
AR
AATK-----
-
R
SGT
I
A
F
S
G
A
YHG
R
T
--------
HY
T
LA
L
TGKVNP
-
YSAGM
G
LM
P
G
H
VYRALYPCPLHGISEDDAIASIHRIFKN
D
AAPEDI
AAI
V
I
EPV
-
QG
E
GG
FYAAT
P
A
F
M
QR
LR
A
LCDE
H
GI
M
LI
A
DEV
QS
G
AG
RTG
T
LFA
MEQMGVA
PDL
T
T
F
AK
S
I
A
GG
-
F
PL
A
G
VT
G
R
AEVM
D
A
VA
PG
G
--
---L
G
G
T
YA
GNP
I
A
C
V
AA
L
E
V
L
KVFEQENLL
Q
KANDLGQ
K
L
K
D
G
L
LA
I
A
E
KHPEIG
DVRGLG
fig|83334.1.peg.3517
Escherichia coli O157:H7 (22-352/426)
I
H
PI
F
A
D
-
---
--R
AE
N
CR
V
W
D
V
EG
RE
Y
L
D
FAG
GI
AVLNT
GH
L
HP
K
V
V
AAV
-
E
A
Q
LKKLS
H
TCFQVLAY
E
PY
L
E
L
C
E
I
M
NQKV
P
GDFAKK
T
LLVT
T
GSEA
V
E
N
A
V
K
I
AR
AATK-----
-
R
SGT
I
A
F
S
G
A
YHG
R
T
--------
HY
T
LA
L
TGKVNP
-
YSAGM
G
LM
P
G
H
VYRALYPCPLHGISEDDAIASIHRIFKN
D
AAPEDI
AAI
V
I
EPV
-
QG
E
GG
FYAAT
P
A
F
M
QR
LR
A
LCDE
H
GI
M
LI
A
DEV
QS
G
AG
RTG
T
LFA
MEQMGVA
PDL
T
T
F
AK
S
I
A
GG
-
F
PL
A
G
VT
G
R
AEVM
D
A
VA
PG
G
--
---L
G
G
T
YA
GNP
I
A
C
V
AA
L
E
V
L
KVFEQENLL
Q
KANDLGQ
K
L
K
D
G
L
LA
I
A
E
KHPEIG
DVRGLG
fig|444454.5.peg.2551
Escherichia coli O157:H7 str. EC4024 (22-352/426)
I
H
PI
F
A
D
-
---
--R
AE
N
CR
V
W
D
V
EG
RE
Y
L
D
FAG
GI
AVLNT
GH
L
HP
K
V
V
AAV
-
E
A
Q
LKKLS
H
TCFQVLAY
E
PY
L
E
L
C
E
I
M
NQKV
P
GDFAKK
T
LLVT
T
GSEA
V
E
N
A
V
K
I
AR
AATK-----
-
R
SGT
I
A
F
S
G
A
YHG
R
T
--------
HY
T
LA
L
TGKVNP
-
YSAGM
G
LM
P
G
H
VYRALYPCPLHGISEDDAIASIHRIFKN
D
AAPEDI
AAI
V
I
EPV
-
QG
E
GG
FYAAT
P
A
F
M
QR
LR
A
LCDE
H
GI
M
LI
A
DEV
QS
G
AG
RTG
T
LFA
MEQMGVA
PDL
T
T
F
AK
S
I
A
GG
-
F
PL
A
G
VT
G
R
AEVM
D
A
VA
PG
G
--
---L
G
G
T
YA
GNP
I
A
C
V
AA
L
E
V
L
KVFEQENLL
Q
KANDLGQ
K
L
K
D
G
L
LA
I
A
E
KHPEIG
DVRGLG
fig|444449.5.peg.2014
Escherichia coli O157:H7 str. EC4042 (22-352/426)
I
H
PI
F
A
D
-
---
--R
AE
N
CR
V
W
D
V
EG
RE
Y
L
D
FAG
GI
AVLNT
GH
L
HP
K
V
V
AAV
-
E
A
Q
LKKLS
H
TCFQVLAY
E
PY
L
E
L
C
E
I
M
NQKV
P
GDFAKK
T
LLVT
T
GSEA
V
E
N
A
V
K
I
AR
AATK-----
-
R
SGT
I
A
F
S
G
A
YHG
R
T
--------
HY
T
LA
L
TGKVNP
-
YSAGM
G
LM
P
G
H
VYRALYPCPLHGISEDDAIASIHRIFKN
D
AAPEDI
AAI
V
I
EPV
-
QG
E
GG
FYAAT
P
A
F
M
QR
LR
A
LCDE
H
GI
M
LI
A
DEV
QS
G
AG
RTG
T
LFA
MEQMGVA
PDL
T
T
F
AK
S
I
A
GG
-
F
PL
A
G
VT
G
R
AEVM
D
A
VA
PG
G
--
---L
G
G
T
YA
GNP
I
A
C
V
AA
L
E
V
L
KVFEQENLL
Q
KANDLGQ
K
L
K
D
G
L
LA
I
A
E
KHPEIG
DVRGLG
fig|444448.5.peg.769
Escherichia coli O157:H7 str. EC4045 (22-352/426)
I
H
PI
F
A
D
-
---
--R
AE
N
CR
V
W
D
V
EG
RE
Y
L
D
FAG
GI
AVLNT
GH
L
HP
K
V
V
AAV
-
E
A
Q
LKKLS
H
TCFQVLAY
E
PY
L
E
L
C
E
I
M
NQKV
P
GDFAKK
T
LLVT
T
GSEA
V
E
N
A
V
K
I
AR
AATK-----
-
R
SGT
I
A
F
S
G
A
YHG
R
T
--------
HY
T
LA
L
TGKVNP
-
YSAGM
G
LM
P
G
H
VYRALYPCPLHGISEDDAIASIHRIFKN
D
AAPEDI
AAI
V
I
EPV
-
QG
E
GG
FYAAT
P
A
F
M
QR
LR
A
LCDE
H
GI
M
LI
A
DEV
QS
G
AG
RTG
T
LFA
MEQMGVA
PDL
T
T
F
AK
S
I
A
GG
-
F
PL
A
G
VT
G
R
AEVM
D
A
VA
PG
G
--
---L
G
G
T
YA
GNP
I
A
C
V
AA
L
E
V
L
KVFEQENLL
Q
KANDLGQ
K
L
K
D
G
L
LA
I
A
E
KHPEIG
DVRGLG
fig|444453.5.peg.251
Escherichia coli O157:H7 str. EC4076 (22-352/426)
I
H
PI
F
A
D
-
---
--R
AE
N
CR
V
W
D
V
EG
RE
Y
L
D
FAG
GI
AVLNT
GH
L
HP
K
V
V
AAV
-
E
A
Q
LKKLS
H
TCFQVLAY
E
PY
L
E
L
C
E
I
M
NQKV
P
GDFAKK
T
LLVT
T
GSEA
V
E
N
A
V
K
I
AR
AATK-----
-
R
SGT
I
A
F
S
G
A
YHG
R
T
--------
HY
T
LA
L
TGKVNP
-
YSAGM
G
LM
P
G
H
VYRALYPCPLHGISEDDAIASIHRIFKN
D
AAPEDI
AAI
V
I
EPV
-
QG
E
GG
FYAAT
P
A
F
M
QR
LR
A
LCDE
H
GI
M
LI
A
DEV
QS
G
AG
RTG
T
LFA
MEQMGVA
PDL
T
T
F
AK
S
I
A
GG
-
F
PL
A
G
VT
G
R
AEVM
D
A
VA
PG
G
--
---L
G
G
T
YA
GNP
I
A
C
V
AA
L
E
V
L
KVFEQENLL
Q
KANDLGQ
K
L
K
D
G
L
LA
I
A
E
KHPEIG
DVRGLG
fig|444452.5.peg.3813
Escherichia coli O157:H7 str. EC4113 (22-352/426)
I
H
PI
F
A
D
-
---
--R
AE
N
CR
V
W
D
V
EG
RE
Y
L
D
FAG
GI
AVLNT
GH
L
HP
K
V
V
AAV
-
E
A
Q
LKKLS
H
TCFQVLAY
E
PY
L
E
L
C
E
I
M
NQKV
P
GDFAKK
T
LLVT
T
GSEA
V
E
N
A
V
K
I
AR
AATK-----
-
R
SGT
I
A
F
S
G
A
YHG
R
T
--------
HY
T
LA
L
TGKVNP
-
YSAGM
G
LM
P
G
H
VYRALYPCPLHGISEDDAIASIHRIFKN
D
AAPEDI
AAI
V
I
EPV
-
QG
E
GG
FYAAT
P
A
F
M
QR
LR
A
LCDE
H
GI
M
LI
A
DEV
QS
G
AG
RTG
T
LFA
MEQMGVA
PDL
T
T
F
AK
S
I
A
GG
-
F
PL
A
G
VT
G
R
AEVM
D
A
VA
PG
G
--
---L
G
G
T
YA
GNP
I
A
C
V
AA
L
E
V
L
KVFEQENLL
Q
KANDLGQ
K
L
K
D
G
L
LA
I
A
E
KHPEIG
DVRGLG
fig|444450.8.peg.3856
Escherichia coli O157:H7 str. EC4115 (22-352/426)
I
H
PI
F
A
D
-
---
--R
AE
N
CR
V
W
D
V
EG
RE
Y
L
D
FAG
GI
AVLNT
GH
L
HP
K
V
V
AAV
-
E
A
Q
LKKLS
H
TCFQVLAY
E
PY
L
E
L
C
E
I
M
NQKV
P
GDFAKK
T
LLVT
T
GSEA
V
E
N
A
V
K
I
AR
AATK-----
-
R
SGT
I
A
F
S
G
A
YHG
R
T
--------
HY
T
LA
L
TGKVNP
-
YSAGM
G
LM
P
G
H
VYRALYPCPLHGISEDDAIASIHRIFKN
D
AAPEDI
AAI
V
I
EPV
-
QG
E
GG
FYAAT
P
A
F
M
QR
LR
A
LCDE
H
GI
M
LI
A
DEV
QS
G
AG
RTG
T
LFA
MEQMGVA
PDL
T
T
F
AK
S
I
A
GG
-
F
PL
A
G
VT
G
R
AEVM
D
A
VA
PG
G
--
---L
G
G
T
YA
GNP
I
A
C
V
AA
L
E
V
L
KVFEQENLL
Q
KANDLGQ
K
L
K
D
G
L
LA
I
A
E
KHPEIG
DVRGLG
fig|444451.5.peg.2446
Escherichia coli O157:H7 str. EC4196 (22-352/426)
I
H
PI
F
A
D
-
---
--R
AE
N
CR
V
W
D
V
EG
RE
Y
L
D
FAG
GI
AVLNT
GH
L
HP
K
V
V
AAV
-
E
A
Q
LKKLS
H
TCFQVLAY
E
PY
L
E
L
C
E
I
M
NQKV
P
GDFAKK
T
LLVT
T
GSEA
V
E
N
A
V
K
I
AR
AATK-----
-
R
SGT
I
A
F
S
G
A
YHG
R
T
--------
HY
T
LA
L
TGKVNP
-
YSAGM
G
LM
P
G
H
VYRALYPCPLHGISEDDAIASIHRIFKN
D
AAPEDI
AAI
V
I
EPV
-
QG
E
GG
FYAAT
P
A
F
M
QR
LR
A
LCDE
H
GI
M
LI
A
DEV
QS
G
AG
RTG
T
LFA
MEQMGVA
PDL
T
T
F
AK
S
I
A
GG
-
F
PL
A
G
VT
G
R
AEVM
D
A
VA
PG
G
--
---L
G
G
T
YA
GNP
I
A
C
V
AA
L
E
V
L
KVFEQENLL
Q
KANDLGQ
K
L
K
D
G
L
LA
I
A
E
KHPEIG
DVRGLG
fig|444447.5.peg.914
Escherichia coli O157:H7 str. EC4206 (22-352/426)
I
H
PI
F
A
D
-
---
--R
AE
N
CR
V
W
D
V
EG
RE
Y
L
D
FAG
GI
AVLNT
GH
L
HP
K
V
V
AAV
-
E
A
Q
LKKLS
H
TCFQVLAY
E
PY
L
E
L
C
E
I
M
NQKV
P
GDFAKK
T
LLVT
T
GSEA
V
E
N
A
V
K
I
AR
AATK-----
-
R
SGT
I
A
F
S
G
A
YHG
R
T
--------
HY
T
LA
L
TGKVNP
-
YSAGM
G
LM
P
G
H
VYRALYPCPLHGISEDDAIASIHRIFKN
D
AAPEDI
AAI
V
I
EPV
-
QG
E
GG
FYAAT
P
A
F
M
QR
LR
A
LCDE
H
GI
M
LI
A
DEV
QS
G
AG
RTG
T
LFA
MEQMGVA
PDL
T
T
F
AK
S
I
A
GG
-
F
PL
A
G
VT
G
R
AEVM
D
A
VA
PG
G
--
---L
G
G
T
YA
GNP
I
A
C
V
AA
L
E
V
L
KVFEQENLL
Q
KANDLGQ
K
L
K
D
G
L
LA
I
A
E
KHPEIG
DVRGLG
fig|478004.5.peg.2181
Escherichia coli O157:H7 str. EC4401 (22-352/426)
I
H
PI
F
A
D
-
---
--R
AE
N
CR
V
W
D
V
EG
RE
Y
L
D
FAG
GI
AVLNT
GH
L
HP
K
V
V
AAV
-
E
A
Q
LKKLS
H
TCFQVLAY
E
PY
L
E
L
C
E
I
M
NQKV
P
GDFAKK
T
LLVT
T
GSEA
V
E
N
A
V
K
I
AR
AATK-----
-
R
SGT
I
A
F
S
G
A
YHG
R
T
--------
HY
T
LA
L
TGKVNP
-
YSAGM
G
LM
P
G
H
VYRALYPCPLHGISEDDAIASIHRIFKN
D
AAPEDI
AAI
V
I
EPV
-
QG
E
GG
FYAAT
P
A
F
M
QR
LR
A
LCDE
H
GI
M
LI
A
DEV
QS
G
AG
RTG
T
LFA
MEQMGVA
PDL
T
T
F
AK
S
I
A
GG
-
F
PL
A
G
VT
G
R
AEVM
D
A
VA
PG
G
--
---L
G
G
T
YA
GNP
I
A
C
V
AA
L
E
V
L
KVFEQENLL
Q
KANDLGQ
K
L
K
D
G
L
LA
I
A
E
KHPEIG
DVRGLG
fig|478005.5.peg.2726
Escherichia coli O157:H7 str. EC4486 (22-352/426)
I
H
PI
F
A
D
-
---
--R
AE
N
CR
V
W
D
V
EG
RE
Y
L
D
FAG
GI
AVLNT
GH
L
HP
K
V
V
AAV
-
E
A
Q
LKKLS
H
TCFQVLAY
E
PY
L
E
L
C
E
I
M
NQKV
P
GDFAKK
T
LLVT
T
GSEA
V
E
N
A
V
K
I
AR
AATK-----
-
R
SGT
I
A
F
S
G
A
YHG
R
T
--------
HY
T
LA
L
TGKVNP
-
YSAGM
G
LM
P
G
H
VYRALYPCPLHGISEDDAIASIHRIFKN
D
AAPEDI
AAI
V
I
EPV
-
QG
E
GG
FYAAT
P
A
F
M
QR
LR
A
LCDE
H
GI
M
LI
A
DEV
QS
G
AG
RTG
T
LFA
MEQMGVA
PDL
T
T
F
AK
S
I
A
GG
-
F
PL
A
G
VT
G
R
AEVM
D
A
VA
PG
G
--
---L
G
G
T
YA
GNP
I
A
C
V
AA
L
E
V
L
KVFEQENLL
Q
KANDLGQ
K
L
K
D
G
L
LA
I
A
E
KHPEIG
DVRGLG
fig|478006.5.peg.2899
Escherichia coli O157:H7 str. EC4501 (22-352/426)
I
H
PI
F
A
D
-
---
--R
AE
N
CR
V
W
D
V
EG
RE
Y
L
D
FAG
GI
AVLNT
GH
L
HP
K
V
V
AAV
-
E
A
Q
LKKLS
H
TCFQVLAY
E
PY
L
E
L
C
E
I
M
NQKV
P
GDFAKK
T
LLVT
T
GSEA
V
E
N
A
V
K
I
AR
AATK-----
-
R
SGT
I
A
F
S
G
A
YHG
R
T
--------
HY
T
LA
L
TGKVNP
-
YSAGM
G
LM
P
G
H
VYRALYPCPLHGISEDDAIASIHRIFKN
D
AAPEDI
AAI
V
I
EPV
-
QG
E
GG
FYAAT
P
A
F
M
QR
LR
A
LCDE
H
GI
M
LI
A
DEV
QS
G
AG
RTG
T
LFA
MEQMGVA
PDL
T
T
F
AK
S
I
A
GG
-
F
PL
A
G
VT
G
R
AEVM
D
A
VA
PG
G
--
---L
G
G
T
YA
GNP
I
A
C
V
AA
L
E
V
L
KVFEQENLL
Q
KANDLGQ
K
L
K
D
G
L
LA
I
A
E
KHPEIG
DVRGLG
fig|478007.5.peg.3218
Escherichia coli O157:H7 str. EC508 (22-352/426)
I
H
PI
F
A
D
-
---
--R
AE
N
CR
V
W
D
V
EG
RE
Y
L
D
FAG
GI
AVLNT
GH
L
HP
K
V
V
AAV
-
E
A
Q
LKKLS
H
TCFQVLAY
E
PY
L
E
L
C
E
I
M
NQKV
P
GDFAKK
T
LLVT
T
GSEA
V
E
N
A
V
K
I
AR
AATK-----
-
R
SGT
I
A
F
S
G
A
YHG
R
T
--------
HY
T
LA
L
TGKVNP
-
YSAGM
G
LM
P
G
H
VYRALYPCPLHGISEDDAIASIHRIFKN
D
AAPEDI
AAI
V
I
EPV
-
QG
E
GG
FYAAT
P
A
F
M
QR
LR
A
LCDE
H
GI
M
LI
A
DEV
QS
G
AG
RTG
T
LFA
MEQMGVA
PDL
T
T
F
AK
S
I
A
GG
-
F
PL
A
G
VT
G
R
AEVM
D
A
VA
PG
G
--
---L
G
G
T
YA
GNP
I
A
C
V
AA
L
E
V
L
KVFEQENLL
Q
KANDLGQ
K
L
K
D
G
L
LA
I
A
E
KHPEIG
DVRGLG
fig|478008.5.peg.4633
Escherichia coli O157:H7 str. EC869 (22-352/426)
I
H
PI
F
A
D
-
---
--R
AE
N
CR
V
W
D
V
EG
RE
Y
L
D
FAG
GI
AVLNT
GH
L
HP
K
V
V
AAV
-
E
A
Q
LKKLS
H
TCFQVLAY
E
PY
L
E
L
C
E
I
M
NQKV
P
GDFAKK
T
LLVT
T
GSEA
V
E
N
A
V
K
I
AR
AATK-----
-
R
SGT
I
A
F
S
G
A
YHG
R
T
--------
HY
T
LA
L
TGKVNP
-
YSAGM
G
LM
P
G
H
VYRALYPCPLHGISEDDAIASIHRIFKN
D
AAPEDI
AAI
V
I
EPV
-
QG
E
GG
FYAAT
P
A
F
M
QR
LR
A
LCDE
H
GI
M
LI
A
DEV
QS
G
AG
RTG
T
LFA
MEQMGVA
PDL
T
T
F
AK
S
I
A
GG
-
F
PL
A
G
VT
G
R
AEVM
D
A
VA
PG
G
--
---L
G
G
T
YA
GNP
I
A
C
V
AA
L
E
V
L
KVFEQENLL
Q
KANDLGQ
K
L
K
D
G
L
LA
I
A
E
KHPEIG
DVRGLG
fig|637388.3.peg.3054
Escherichia coli O157:H7 str. FRIK2000 (22-352/426)
I
H
PI
F
A
D
-
---
--R
AE
N
CR
V
W
D
V
EG
RE
Y
L
D
FAG
GI
AVLNT
GH
L
HP
K
V
V
AAV
-
E
A
Q
LKKLS
H
TCFQVLAY
E
PY
L
E
L
C
E
I
M
NQKV
P
GDFAKK
T
LLVT
T
GSEA
V
E
N
A
V
K
I
AR
AATK-----
-
R
SGT
I
A
F
S
G
A
YHG
R
T
--------
HY
T
LA
L
TGKVNP
-
YSAGM
G
LM
P
G
H
VYRALYPCPLHGISEDDAIASIHRIFKN
D
AAPEDI
AAI
V
I
EPV
-
QG
E
GG
FYAAT
P
A
F
M
QR
LR
A
LCDE
H
GI
M
LI
A
DEV
QS
G
AG
RTG
T
LFA
MEQMGVA
PDL
T
T
F
AK
S
I
A
GG
-
F
PL
A
G
VT
G
R
AEVM
D
A
VA
PG
G
--
---L
G
G
T
YA
GNP
I
A
C
V
AA
L
E
V
L
KVFEQENLL
Q
KANDLGQ
K
L
K
D
G
L
LA
I
A
E
KHPEIG
DVRGLG
fig|570506.3.peg.2667
Escherichia coli O157:H7 str. FRIK966 (22-352/426)
I
H
PI
F
A
D
-
---
--R
AE
N
CR
V
W
D
V
EG
RE
Y
L
D
FAG
GI
AVLNT
GH
L
HP
K
V
V
AAV
-
E
A
Q
LKKLS
H
TCFQVLAY
E
PY
L
E
L
C
E
I
M
NQKV
P
GDFAKK
T
LLVT
T
GSEA
V
E
N
A
V
K
I
AR
AATK-----
-
R
SGT
I
A
F
S
G
A
YHG
R
T
--------
HY
T
LA
L
TGKVNP
-
YSAGM
G
LM
P
G
H
VYRALYPCPLHGISEDDAIASIHRIFKN
D
AAPEDI
AAI
V
I
EPV
-
QG
E
GG
FYAAT
P
A
F
M
QR
LR
A
LCDE
H
GI
M
LI
A
DEV
QS
G
AG
RTG
T
LFA
MEQMGVA
PDL
T
T
F
AK
S
I
A
GG
-
F
PL
A
G
VT
G
R
AEVM
D
A
VA
PG
G
--
---L
G
G
T
YA
GNP
I
A
C
V
AA
L
E
V
L
KVFEQENLL
Q
KANDLGQ
K
L
K
D
G
L
LA
I
A
E
KHPEIG
DVRGLG
fig|386585.9.peg.3677
Escherichia coli O157:H7 str. Sakai (22-352/426)
I
H
PI
F
A
D
-
---
--R
AE
N
CR
V
W
D
V
EG
RE
Y
L
D
FAG
GI
AVLNT
GH
L
HP
K
V
V
AAV
-
E
A
Q
LKKLS
H
TCFQVLAY
E
PY
L
E
L
C
E
I
M
NQKV
P
GDFAKK
T
LLVT
T
GSEA
V
E
N
A
V
K
I
AR
AATK-----
-
R
SGT
I
A
F
S
G
A
YHG
R
T
--------
HY
T
LA
L
TGKVNP
-
YSAGM
G
LM
P
G
H
VYRALYPCPLHGISEDDAIASIHRIFKN
D
AAPEDI
AAI
V
I
EPV
-
QG
E
GG
FYAAT
P
A
F
M
QR
LR
A
LCDE
H
GI
M
LI
A
DEV
QS
G
AG
RTG
T
LFA
MEQMGVA
PDL
T
T
F
AK
S
I
A
GG
-
F
PL
A
G
VT
G
R
AEVM
D
A
VA
PG
G
--
---L
G
G
T
YA
GNP
I
A
C
V
AA
L
E
V
L
KVFEQENLL
Q
KANDLGQ
K
L
K
D
G
L
LA
I
A
E
KHPEIG
DVRGLG
fig|544404.4.peg.3660
Escherichia coli O157:H7 str. TW14359 (22-352/426)
I
H
PI
F
A
D
-
---
--R
AE
N
CR
V
W
D
V
EG
RE
Y
L
D
FAG
GI
AVLNT
GH
L
HP
K
V
V
AAV
-
E
A
Q
LKKLS
H
TCFQVLAY
E
PY
L
E
L
C
E
I
M
NQKV
P
GDFAKK
T
LLVT
T
GSEA
V
E
N
A
V
K
I
AR
AATK-----
-
R
SGT
I
A
F
S
G
A
YHG
R
T
--------
HY
T
LA
L
TGKVNP
-
YSAGM
G
LM
P
G
H
VYRALYPCPLHGISEDDAIASIHRIFKN
D
AAPEDI
AAI
V
I
EPV
-
QG
E
GG
FYAAT
P
A
F
M
QR
LR
A
LCDE
H
GI
M
LI
A
DEV
QS
G
AG
RTG
T
LFA
MEQMGVA
PDL
T
T
F
AK
S
I
A
GG
-
F
PL
A
G
VT
G
R
AEVM
D
A
VA
PG
G
--
---L
G
G
T
YA
GNP
I
A
C
V
AA
L
E
V
L
KVFEQENLL
Q
KANDLGQ
K
L
K
D
G
L
LA
I
A
E
KHPEIG
DVRGLG
fig|502346.5.peg.3754
Escherichia coli O157:H7 str. TW14588 (22-352/426)
I
H
PI
F
A
D
-
---
--R
AE
N
CR
V
W
D
V
EG
RE
Y
L
D
FAG
GI
AVLNT
GH
L
HP
K
V
V
AAV
-
E
A
Q
LKKLS
H
TCFQVLAY
E
PY
L
E
L
C
E
I
M
NQKV
P
GDFAKK
T
LLVT
T
GSEA
V
E
N
A
V
K
I
AR
AATK-----
-
R
SGT
I
A
F
S
G
A
YHG
R
T
--------
HY
T
LA
L
TGKVNP
-
YSAGM
G
LM
P
G
H
VYRALYPCPLHGISEDDAIASIHRIFKN
D
AAPEDI
AAI
V
I
EPV
-
QG
E
GG
FYAAT
P
A
F
M
QR
LR
A
LCDE
H
GI
M
LI
A
DEV
QS
G
AG
RTG
T
LFA
MEQMGVA
PDL
T
T
F
AK
S
I
A
GG
-
F
PL
A
G
VT
G
R
AEVM
D
A
VA
PG
G
--
---L
G
G
T
YA
GNP
I
A
C
V
AA
L
E
V
L
KVFEQENLL
Q
KANDLGQ
K
L
K
D
G
L
LA
I
A
E
KHPEIG
DVRGLG
fig|701177.3.peg.3323
Escherichia coli O55:H7 str. CB9615 (22-352/426)
I
H
PI
F
A
D
-
---
--R
AE
N
CR
V
W
D
V
EG
RE
Y
L
D
FAG
GI
AVLNT
GH
L
HP
K
V
V
AAV
-
E
A
Q
LKKLS
H
TCFQVLAY
E
PY
L
E
L
C
E
I
M
NQKV
P
GDFAKK
T
LLVT
T
GSEA
V
E
N
A
V
K
I
AR
AATK-----
-
R
SGT
I
A
F
S
G
A
YHG
R
T
--------
HY
T
LA
L
TGKVNP
-
YSAGM
G
LM
P
G
H
VYRALYPCPLHGISEDDAIASIHRIFKN
D
AAPEDI
AAI
V
I
EPV
-
QG
E
GG
FYAAT
P
A
F
M
QR
LR
A
LCDE
H
GI
M
LI
A
DEV
QS
G
AG
RTG
T
LFA
MEQMGVA
PDL
T
T
F
AK
S
I
A
GG
-
F
PL
A
G
VT
G
R
AEVM
D
A
VA
PG
G
--
---L
G
G
T
YA
GNP
I
A
C
V
AA
L
E
V
L
KVFEQENLL
Q
KANDLGQ
K
L
K
D
G
L
LA
I
A
E
KHPEIG
DVRGLG
fig|656443.3.peg.3414
Escherichia coli TA271 (22-352/426)
I
H
PI
F
A
D
-
---
--R
AE
N
CR
V
W
D
V
EG
RE
Y
L
D
FAG
GI
AVLNT
GH
L
HP
K
V
V
AAV
-
E
A
Q
LKKLS
H
TCFQVLAY
E
PY
L
E
L
C
E
I
M
NQKV
P
GDFAKK
T
LLVT
T
GSEA
V
E
N
A
V
K
I
AR
AATK-----
-
R
SGT
I
A
F
S
G
A
YHG
R
T
--------
HY
T
LA
L
TGKVNP
-
YSAGM
G
LM
P
G
H
VYRALYPCPLHGISEDDAIASIHRIFKN
D
AAPEDI
AAI
V
I
EPV
-
QG
E
GG
FYAAT
P
A
F
M
QR
LR
A
LCDE
H
GI
M
LI
A
DEV
QS
G
AG
RTG
T
LFA
MEQMGVA
PDL
T
T
F
AK
S
I
A
GG
-
F
PL
A
G
VT
G
R
AEVM
D
A
VA
PG
G
--
---L
G
G
T
YA
GNP
I
A
C
V
AA
L
E
V
L
KVFEQENLL
Q
KANDLGQ
K
L
K
D
G
L
LA
I
A
E
KHPEIG
DVRGLG
fig|566546.3.peg.4293
Escherichia coli W (22-352/426)
I
H
PI
F
A
D
-
---
--R
AE
N
CR
V
W
D
V
EG
RE
Y
L
D
FAG
GI
AVLNT
GH
L
HP
K
V
V
AAV
-
E
A
Q
LKKLS
H
TCFQVLAY
E
PY
L
E
L
C
E
I
M
NQKV
P
GDFAKK
T
LLVT
T
GSEA
V
E
N
A
V
K
I
AR
AATK-----
-
R
SGT
I
A
F
S
G
A
YHG
R
T
--------
HY
T
LA
L
TGKVNP
-
YSAGM
G
LM
P
G
H
VYRALYPCPLHGISEDDAIASIHRIFKN
D
AAPEDI
AAI
V
I
EPV
-
QG
E
GG
FYAAT
P
A
F
M
QR
LR
A
LCDE
H
GI
M
LI
A
DEV
QS
G
AG
RTG
T
LFA
MEQMGVA
PDL
T
T
F
AK
S
I
A
GG
-
F
PL
A
G
VT
G
R
AEVM
D
A
VA
PG
G
--
---L
G
G
T
YA
GNP
I
A
C
V
AA
L
E
V
L
KVFEQENLL
Q
KANDLGQ
K
L
K
D
G
L
LA
I
A
E
KHPEIG
DVRGLG
fig|566546.4.peg.2824
Escherichia coli W (22-352/426)
I
H
PI
F
A
D
-
---
--R
AE
N
CR
V
W
D
V
EG
RE
Y
L
D
FAG
GI
AVLNT
GH
L
HP
K
V
V
AAV
-
E
A
Q
LKKLS
H
TCFQVLAY
E
PY
L
E
L
C
E
I
M
NQKV
P
GDFAKK
T
LLVT
T
GSEA
V
E
N
A
V
K
I
AR
AATK-----
-
R
SGT
I
A
F
S
G
A
YHG
R
T
--------
HY
T
LA
L
TGKVNP
-
YSAGM
G
LM
P
G
H
VYRALYPCPLHGISEDDAIASIHRIFKN
D
AAPEDI
AAI
V
I
EPV
-
QG
E
GG
FYAAT
P
A
F
M
QR
LR
A
LCDE
H
GI
M
LI
A
DEV
QS
G
AG
RTG
T
LFA
MEQMGVA
PDL
T
T
F
AK
S
I
A
GG
-
F
PL
A
G
VT
G
R
AEVM
D
A
VA
PG
G
--
---L
G
G
T
YA
GNP
I
A
C
V
AA
L
E
V
L
KVFEQENLL
Q
KANDLGQ
K
L
K
D
G
L
LA
I
A
E
KHPEIG
DVRGLG
fig|409438.11.peg.3081
Escherichia coli SE11 (22-352/426)
I
H
PI
F
A
D
-
---
--R
AE
N
CR
V
W
D
V
EG
RE
Y
L
D
FAG
GI
AVLNT
GH
L
HP
K
V
V
AAV
-
E
A
Q
LKKLS
H
TCFQVLAY
E
PY
L
E
L
C
E
I
M
NQKV
P
GDFAKK
T
LLVT
T
GSEA
V
E
N
A
V
K
I
AR
AATK-----
-
R
SGT
I
A
F
S
G
A
YHG
R
T
--------
HY
T
LA
L
TGKVNP
-
YSAGM
G
LM
P
G
H
VYRALYPCPLHGISEDDAIASIHRIFKN
D
AAPEDI
AAI
V
I
EPV
-
QG
E
GG
FYAAS
P
A
F
M
QR
LR
A
LCDE
H
G
LM
LI
A
DEV
QS
G
AG
RTG
T
LFA
MEQMGVA
PDL
T
T
F
AK
S
I
A
GG
-
F
PL
A
G
VT
G
R
AEVM
D
A
VA
PG
G
--
---L
G
G
T
YA
GNP
I
A
C
V
AA
L
E
V
L
KVFEQENLL
Q
KANDLGQ
K
L
K
D
G
L
LA
I
A
E
KHPEIG
DVRGLG
fig|155864.1.peg.3519
Escherichia coli O157:H7 EDL933 (22-352/426)
I
H
PI
F
A
D
-
---
--R
AE
N
CR
V
W
D
V
EG
RE
Y
L
D
FAG
GI
AVLNT
GH
L
HP
K
V
V
AAV
-
E
A
Q
LKKLS
H
TCFQVLAY
E
PY
L
E
L
C
E
I
M
NQKV
P
GDFAKK
T
LLVT
T
GSEA
V
E
N
A
V
K
I
AR
AATK-----
-
R
SGT
I
A
F
S
G
A
YHG
R
T
--------
HY
T
LA
L
TGKVNP
-
YSAGM
G
LM
P
G
H
VYRALYPCPLHGISEDDAIASIHRIFKN
D
AAPEDI
AAI
V
I
EPV
-
QG
E
GG
FYAAT
P
A
F
M
QR
LR
A
LCDE
H
GI
M
LI
A
DEV
QX
G
AG
RTG
T
LFA
MEQMGVA
PDL
T
T
F
AK
S
I
A
GG
-
F
PL
A
G
VT
G
R
AEVM
D
A
VA
PG
G
--
---L
G
G
T
YA
GNP
I
A
C
V
AA
L
E
V
L
KVFEQENLL
Q
KANDLGQ
K
L
K
D
G
L
LA
I
A
E
KHPEIG
DVRGLG
fig|155864.8.peg.3432
Escherichia coli O157:H7 EDL933 (22-352/426)
I
H
PI
F
A
D
-
---
--R
AE
N
CR
V
W
D
V
EG
RE
Y
L
D
FAG
GI
AVLNT
GH
L
HP
K
V
V
AAV
-
E
A
Q
LKKLS
H
TCFQVLAY
E
PY
L
E
L
C
E
I
M
NQKV
P
GDFAKK
T
LLVT
T
GSEA
V
E
N
A
V
K
I
AR
AATK-----
-
R
SGT
I
A
F
S
G
A
YHG
R
T
--------
HY
T
LA
L
TGKVNP
-
YSAGM
G
LM
P
G
H
VYRALYPCPLHGISEDDAIASIHRIFKN
D
AAPEDI
AAI
V
I
EPV
-
QG
E
GG
FYAAT
P
A
F
M
QR
LR
A
LCDE
H
GI
M
LI
A
DEV
QX
G
AG
RTG
T
LFA
MEQMGVA
PDL
T
T
F
AK
S
I
A
GG
-
F
PL
A
G
VT
G
R
AEVM
D
A
VA
PG
G
--
---L
G
G
T
YA
GNP
I
A
C
V
AA
L
E
V
L
KVFEQENLL
Q
KANDLGQ
K
L
K
D
G
L
LA
I
A
E
KHPEIG
DVRGLG
fig|362663.8.peg.2658
Escherichia coli 536 (22-352/426)
I
H
PI
F
A
D
-
---
--R
AE
N
CR
V
W
D
V
EG
RE
Y
L
D
FAG
GI
AVLNT
GH
L
HP
K
V
V
AAV
-
E
A
Q
LKKLS
H
TCFQVLAY
E
PY
L
E
L
C
E
I
M
NQKV
P
GDFAKK
T
LLVT
T
GSEA
V
E
N
A
V
K
I
AR
AATK-----
-
R
SGT
I
A
F
S
G
A
YHG
R
T
--------
HY
T
LA
L
TGKVNP
-
YSAGM
G
LM
P
G
H
VYRALYPCPLHGISEDDAIASIHRIFKN
D
AAPEDI
AAI
V
I
EPV
-
QG
E
GG
FYAAT
P
A
F
M
QR
LR
A
LCDE
H
GI
M
LI
A
DEV
QS
G
AG
RTG
T
LFA
MEQMGVA
PDL
T
T
F
AK
S
I
A
GG
-
F
PL
A
G
VT
G
R
AEVM
D
A
VA
PG
G
--
---L
G
G
T
YA
GNP
I
A
C
V
AA
L
E
V
L
KVFEQENLL
Q
KANDLGH
K
L
K
D
G
L
LA
I
A
E
KHPEIG
D
I
RGLG
fig|362663.9.peg.2663
Escherichia coli 536 (22-352/426)
I
H
PI
F
A
D
-
---
--R
AE
N
CR
V
W
D
V
EG
RE
Y
L
D
FAG
GI
AVLNT
GH
L
HP
K
V
V
AAV
-
E
A
Q
LKKLS
H
TCFQVLAY
E
PY
L
E
L
C
E
I
M
NQKV
P
GDFAKK
T
LLVT
T
GSEA
V
E
N
A
V
K
I
AR
AATK-----
-
R
SGT
I
A
F
S
G
A
YHG
R
T
--------
HY
T
LA
L
TGKVNP
-
YSAGM
G
LM
P
G
H
VYRALYPCPLHGISEDDAIASIHRIFKN
D
AAPEDI
AAI
V
I
EPV
-
QG
E
GG
FYAAT
P
A
F
M
QR
LR
A
LCDE
H
GI
M
LI
A
DEV
QS
G
AG
RTG
T
LFA
MEQMGVA
PDL
T
T
F
AK
S
I
A
GG
-
F
PL
A
G
VT
G
R
AEVM
D
A
VA
PG
G
--
---L
G
G
T
YA
GNP
I
A
C
V
AA
L
E
V
L
KVFEQENLL
Q
KANDLGH
K
L
K
D
G
L
LA
I
A
E
KHPEIG
D
I
RGLG
fig|340197.3.peg.1418
Escherichia coli F11 (22-352/426)
I
H
PI
F
A
D
-
---
--R
AE
N
CR
V
W
D
V
EG
RE
Y
L
D
FAG
GI
AVLNT
GH
L
HP
K
V
V
AAV
-
E
A
Q
LKKLS
H
TCFQVLAY
E
PY
L
E
L
C
E
I
M
NQKV
P
GDFAKK
T
LLVT
T
GSEA
V
E
N
A
V
K
I
AR
AATK-----
-
R
SGT
I
A
F
S
G
A
YHG
R
T
--------
HY
T
LA
L
TGKVNP
-
YSAGM
G
LM
P
G
H
VYRALYPCPLHGISEDDAIASIHRIFKN
D
AAPEDI
AAI
V
I
EPV
-
QG
E
GG
FYAAT
P
A
F
M
QR
LR
A
LCDE
H
GI
M
LI
A
DEV
QS
G
AG
RTG
T
LFA
MEQMGVA
PDL
T
T
F
AK
S
I
A
GG
-
F
PL
A
G
VT
G
R
AEVM
D
A
VA
PG
G
--
---L
G
G
T
YA
GNP
I
A
C
V
AA
L
E
V
L
KVFEQENLL
Q
KANDLGH
K
L
K
D
G
L
LA
I
A
E
KHPEIG
D
I
RGLG
fig|340197.5.peg.1501
Escherichia coli F11 (22-352/426)
I
H
PI
F
A
D
-
---
--R
AE
N
CR
V
W
D
V
EG
RE
Y
L
D
FAG
GI
AVLNT
GH
L
HP
K
V
V
AAV
-
E
A
Q
LKKLS
H
TCFQVLAY
E
PY
L
E
L
C
E
I
M
NQKV
P
GDFAKK
T
LLVT
T
GSEA
V
E
N
A
V
K
I
AR
AATK-----
-
R
SGT
I
A
F
S
G
A
YHG
R
T
--------
HY
T
LA
L
TGKVNP
-
YSAGM
G
LM
P
G
H
VYRALYPCPLHGISEDDAIASIHRIFKN
D
AAPEDI
AAI
V
I
EPV
-
QG
E
GG
FYAAT
P
A
F
M
QR
LR
A
LCDE
H
GI
M
LI
A
DEV
QS
G
AG
RTG
T
LFA
MEQMGVA
PDL
T
T
F
AK
S
I
A
GG
-
F
PL
A
G
VT
G
R
AEVM
D
A
VA
PG
G
--
---L
G
G
T
YA
GNP
I
A
C
V
AA
L
E
V
L
KVFEQENLL
Q
KANDLGH
K
L
K
D
G
L
LA
I
A
E
KHPEIG
D
I
RGLG
fig|749550.3.peg.3532
Escherichia coli MS 200-1 (22-352/426)
I
H
PI
F
A
D
-
---
--R
AE
N
CR
V
W
D
V
EG
RE
Y
L
D
FAG
GI
AVLNT
GH
L
HP
K
V
V
AAV
-
E
A
Q
LKKLS
H
TCFQVLAY
E
PY
L
E
L
C
E
I
M
NQKV
P
GDFAKK
T
LLVT
T
GSEA
V
E
N
A
V
K
I
AR
AATK-----
-
R
SGT
I
A
F
S
G
A
YHG
R
T
--------
HY
T
LA
L
TGKVNP
-
YSAGM
G
LM
P
G
H
VYRALYPCPLHGISEDDAIASIHRIFKN
D
AAPEDI
AAI
V
I
EPV
-
QG
E
GG
FYAAT
P
A
F
M
QR
LR
A
LCDE
H
GI
M
LI
A
DEV
QS
G
AG
RTG
T
LFA
MEQMGVA
PDL
T
T
F
AK
S
I
A
GG
-
F
PL
A
G
VT
G
R
AEVM
D
A
VA
PG
G
--
---L
G
G
T
YA
GNP
I
A
C
V
AA
L
E
V
L
KVFEQENLL
Q
KANDLGH
K
L
K
D
G
L
LA
I
A
E
KHPEIG
D
I
RGLG
fig|562.376.peg.3468
Escherichia coli WV_060327 (22-352/426)
I
H
PI
F
A
D
-
---
--R
AE
N
CR
V
W
D
V
EG
RE
Y
L
D
FAG
GI
AVLNT
GH
L
HP
K
V
V
AAV
-
E
A
Q
LKKLS
H
TCFQVLAY
E
PY
L
E
L
C
E
I
M
NQKV
P
GDFAKK
T
LLVT
T
GSEA
V
E
N
A
V
K
I
AR
AATK-----
-
R
SGT
I
A
F
S
G
A
YHG
R
T
--------
HY
T
LA
L
TGKVNP
-
YSAGM
G
LM
P
G
H
VYRALYPCPLHGISEDDAIASIHRIFKN
D
AAPEDI
AAI
V
I
EPV
-
QG
E
GG
FYAAT
P
A
F
M
QR
LR
A
LCDE
H
GI
M
LI
A
DEV
QS
G
AG
RTG
T
LFA
MEQMGVA
PDL
T
T
F
AK
S
I
A
GG
-
F
PL
A
G
VT
G
R
AEVM
D
A
VA
PG
G
--
---L
G
G
T
YA
GNP
I
A
C
V
AA
L
E
V
L
KVFEQENLL
Q
KANDLGH
K
L
K
D
G
L
LA
I
A
E
KHPEIG
D
I
RGLG
fig|585057.4.peg.2950
Escherichia coli IAI39 (22-352/426)
I
H
PI
F
A
D
-
---
--R
AE
N
CR
V
W
D
V
EG
RE
Y
L
D
FAG
GI
AVLNT
GH
L
HP
K
V
V
AAV
-
E
A
Q
LKKLS
H
TCFQVLAY
E
PY
L
E
L
C
E
I
M
NQKV
P
GDFAKK
T
LLVT
T
GSEA
V
E
N
A
V
K
I
AR
AATK-----
-
R
SGT
I
A
F
S
G
A
YHG
R
T
--------
HY
T
LA
L
TGKVNP
-
YSAGM
G
LM
P
G
H
VYRALYPCPLHGISEDDAIASIHRIFKN
D
AAPEDI
AAI
V
I
EPV
-
QG
E
GG
FYAAT
P
A
F
M
LR
LR
A
LCDE
H
GI
M
LI
A
DEV
QS
G
AG
RTG
T
LFA
MEQMGVA
PDL
T
T
F
AK
S
I
A
GG
-
F
PL
A
G
VT
G
R
AEVM
D
A
VA
PG
G
--
---L
G
G
T
YA
GNP
I
A
C
V
AA
L
E
V
L
KVFEQENLL
Q
KANVLGQ
K
L
K
D
G
L
LA
I
A
E
KHPEIG
DVRGLG
fig|585057.6.peg.2955
Escherichia coli IAI39 (22-352/426)
I
H
PI
F
A
D
-
---
--R
AE
N
CR
V
W
D
V
EG
RE
Y
L
D
FAG
GI
AVLNT
GH
L
HP
K
V
V
AAV
-
E
A
Q
LKKLS
H
TCFQVLAY
E
PY
L
E
L
C
E
I
M
NQKV
P
GDFAKK
T
LLVT
T
GSEA
V
E
N
A
V
K
I
AR
AATK-----
-
R
SGT
I
A
F
S
G
A
YHG
R
T
--------
HY
T
LA
L
TGKVNP
-
YSAGM
G
LM
P
G
H
VYRALYPCPLHGISEDDAIASIHRIFKN
D
AAPEDI
AAI
V
I
EPV
-
QG
E
GG
FYAAT
P
A
F
M
LR
LR
A
LCDE
H
GI
M
LI
A
DEV
QS
G
AG
RTG
T
LFA
MEQMGVA
PDL
T
T
F
AK
S
I
A
GG
-
F
PL
A
G
VT
G
R
AEVM
D
A
VA
PG
G
--
---L
G
G
T
YA
GNP
I
A
C
V
AA
L
E
V
L
KVFEQENLL
Q
KANVLGQ
K
L
K
D
G
L
LA
I
A
E
KHPEIG
DVRGLG
fig|656417.3.peg.3403
Escherichia coli M605 (22-352/426)
I
H
PI
F
A
D
-
---
--R
AE
N
CR
V
W
D
V
EG
RE
Y
L
D
FAG
GI
AVLNT
GH
L
HP
K
V
V
A
T
V
-
E
A
Q
LKKLS
H
TCFQVLAY
E
PY
L
E
L
C
E
I
M
NQKV
P
GDFAKK
T
LLVT
T
GSEA
V
E
N
A
V
K
I
AR
AATK-----
-
R
SGT
I
A
F
S
G
A
YHG
R
T
--------
HY
T
LA
L
TGKVNP
-
YSAGM
G
LM
P
G
H
VYRALYPCPLHGISEDDAIASIHRIFKN
D
AAPEDI
AAI
V
I
EPV
-
QG
E
GG
FYAAT
P
A
F
M
QR
LR
A
LCDE
H
GI
M
LI
A
DEV
QS
G
AG
RTG
T
LFA
MEQMGVA
PDL
T
T
F
AK
S
I
A
GG
-
F
PL
A
G
VT
G
R
AEVM
D
A
VA
PG
G
--
---L
G
G
T
YA
GNP
I
A
C
V
AA
L
E
V
L
KVFEQENLL
Q
KANVLGQ
K
L
K
D
G
L
LA
I
A
E
KHPEIG
DVRGLG
fig|331111.12.peg.3222
Escherichia coli E24377A (22-352/426)
I
H
PI
F
A
D
-
---
--R
AE
N
CR
V
W
D
V
EG
RE
Y
L
D
FAG
GI
AVLNT
GH
L
HP
K
V
V
AAV
-
E
A
Q
LKKLS
H
TCFQVLAY
E
PY
L
E
L
C
E
I
M
NQKV
P
GDFAKK
T
LLVT
T
GSEA
V
E
N
A
V
K
I
AR
AATK-----
-
R
SGT
I
A
F
S
G
A
YHG
R
T
--------
HY
T
LA
L
TGKVNP
-
YSAGM
G
LM
P
G
H
VYRALYPCPLHGISEDDAIASIHRIFKN
D
AAPEDI
A
G
I
V
I
EPV
-
QG
E
GG
FYATT
P
A
F
M
QR
LR
A
LCDE
H
GI
M
LI
A
DEV
QS
G
AG
RTG
T
LFA
MEQMGVA
PDL
T
T
F
AK
S
I
A
GG
-
F
PL
A
G
VT
G
R
AEVM
D
A
VA
PG
G
--
---L
G
G
T
YA
GNP
I
A
C
V
AA
L
E
V
L
KVFEQENLL
Q
KANDLGQ
K
L
K
D
G
L
LA
I
A
E
KHPEIG
DVRGLG
fig|331111.3.peg.665
Escherichia coli E24377A (22-352/426)
I
H
PI
F
A
D
-
---
--R
AE
N
CR
V
W
D
V
EG
RE
Y
L
D
FAG
GI
AVLNT
GH
L
HP
K
V
V
AAV
-
E
A
Q
LKKLS
H
TCFQVLAY
E
PY
L
E
L
C
E
I
M
NQKV
P
GDFAKK
T
LLVT
T
GSEA
V
E
N
A
V
K
I
AR
AATK-----
-
R
SGT
I
A
F
S
G
A
YHG
R
T
--------
HY
T
LA
L
TGKVNP
-
YSAGM
G
LM
P
G
H
VYRALYPCPLHGISEDDAIASIHRIFKN
D
AAPEDI
A
G
I
V
I
EPV
-
QG
E
GG
FYATT
P
A
F
M
QR
LR
A
LCDE
H
GI
M
LI
A
DEV
QS
G
AG
RTG
T
LFA
MEQMGVA
PDL
T
T
F
AK
S
I
A
GG
-
F
PL
A
G
VT
G
R
AEVM
D
A
VA
PG
G
--
---L
G
G
T
YA
GNP
I
A
C
V
AA
L
E
V
L
KVFEQENLL
Q
KANDLGQ
K
L
K
D
G
L
LA
I
A
E
KHPEIG
DVRGLG
fig|749545.3.peg.941
Escherichia coli MS 182-1 (22-352/426)
I
H
PI
F
A
D
-
---
--R
AE
N
CR
V
W
D
V
EG
RE
Y
L
D
FAG
GI
AVLNT
GH
L
HP
K
V
V
AAV
-
E
A
Q
LKKLS
H
TCFQVLAY
E
PY
L
E
L
C
E
I
M
NQKV
P
GDFAKK
T
LLVT
T
GSEA
V
E
N
A
V
K
I
AR
AATK-----
-
R
SGT
I
A
F
S
G
A
YHG
R
T
--------
HY
T
LA
L
TGKVNP
-
YSAGM
G
LM
P
G
H
VYRALYPCPLHGISEDDAIASIHRIFKN
D
AAPEDI
A
G
I
V
I
EPV
-
QG
E
GG
FYATT
P
A
F
M
QR
LR
A
LCDE
H
GI
M
LI
A
DEV
QS
G
AG
RTG
T
LFA
MEQMGVA
PDL
T
T
F
AK
S
I
A
GG
-
F
PL
A
G
VT
G
R
AEVM
D
A
VA
PG
G
--
---L
G
G
T
YA
GNP
I
A
C
V
AA
L
E
V
L
KVFEQENLL
Q
KANDLGQ
K
L
K
D
G
L
LA
I
A
E
KHPEIG
DVRGLG
fig|749532.3.peg.2170
Escherichia coli MS 78-1 (22-352/426)
I
H
PI
F
A
D
-
---
--R
AE
N
CR
V
W
D
V
EG
RE
Y
L
D
FAG
GI
AVLNT
GH
L
HP
K
V
V
AAV
-
E
A
Q
LKKLS
H
TCFQVLAY
E
PY
L
E
L
C
E
I
M
NQKV
P
GDFAKK
T
LLVT
T
GSEA
V
E
N
A
V
K
I
AR
AATK-----
-
R
SGT
I
A
F
S
G
A
YHG
R
T
--------
HY
T
LA
L
TGKVNP
-
YSAGM
G
LM
P
G
H
VYRALYPCPLHGISEDDAIASIHRIFKN
D
AAPEDI
A
G
I
V
I
EPV
-
QG
E
GG
FYATT
P
A
F
M
QR
LR
A
LCDE
H
GI
M
LI
A
DEV
QS
G
AG
RTG
T
LFA
MEQMGVA
PDL
T
T
F
AK
S
I
A
GG
-
F
PL
A
G
VT
G
R
AEVM
D
A
VA
PG
G
--
---L
G
G
T
YA
GNP
I
A
C
V
AA
L
E
V
L
KVFEQENLL
Q
KANDLGQ
K
L
K
D
G
L
LA
I
A
E
KHPEIG
DVRGLG
fig|340184.3.peg.2157
Escherichia coli B7A (22-352/426)
I
H
PI
F
A
D
-
---
--R
AE
N
CR
V
W
D
V
EG
RE
Y
L
D
FSG
GI
AVLNT
GH
L
HP
K
V
V
AAV
-
E
A
Q
LKKLS
H
TCFQVLAY
E
PY
L
E
L
C
E
I
M
NQKV
P
GDFAKK
T
LLVT
T
GSEA
V
E
N
A
V
K
I
AR
AATK-----
-
R
SGT
I
A
F
S
G
A
YHG
R
T
--------
HY
T
LA
L
TGKVNP
-
YSAGM
G
LM
P
G
H
VYRALYPCPLHGISEDDAIASIHRIFKN
D
AAPEDI
AAI
V
I
EPV
-
QG
E
GG
FYAAS
P
A
F
M
QR
LR
A
LCDE
H
GI
M
LI
A
DEV
QS
G
AG
RTG
T
LFA
MEQMGVA
PDL
T
T
F
AK
S
I
A
GG
-
F
PL
A
G
VT
G
R
AEVM
D
A
VA
PG
G
--
---L
G
G
T
YA
GNP
I
A
C
V
AA
L
E
V
L
KVFEQENLL
Q
KANDLGQ
K
L
K
D
G
L
LV
I
A
E
KHPEIG
DVRGLG
fig|340184.6.peg.2263
Escherichia coli B7A (22-352/426)
I
H
PI
F
A
D
-
---
--R
AE
N
CR
V
W
D
V
EG
RE
Y
L
D
FSG
GI
AVLNT
GH
L
HP
K
V
V
AAV
-
E
A
Q
LKKLS
H
TCFQVLAY
E
PY
L
E
L
C
E
I
M
NQKV
P
GDFAKK
T
LLVT
T
GSEA
V
E
N
A
V
K
I
AR
AATK-----
-
R
SGT
I
A
F
S
G
A
YHG
R
T
--------
HY
T
LA
L
TGKVNP
-
YSAGM
G
LM
P
G
H
VYRALYPCPLHGISEDDAIASIHRIFKN
D
AAPEDI
AAI
V
I
EPV
-
QG
E
GG
FYAAS
P
A
F
M
QR
LR
A
LCDE
H
GI
M
LI
A
DEV
QS
G
AG
RTG
T
LFA
MEQMGVA
PDL
T
T
F
AK
S
I
A
GG
-
F
PL
A
G
VT
G
R
AEVM
D
A
VA
PG
G
--
---L
G
G
T
YA
GNP
I
A
C
V
AA
L
E
V
L
KVFEQENLL
Q
KANDLGQ
K
L
K
D
G
L
LV
I
A
E
KHPEIG
DVRGLG
fig|679204.3.peg.2257
Escherichia coli MS 145-7 (22-352/426)
I
H
PI
F
A
D
-
---
--R
AE
N
CR
V
W
D
V
EG
RE
Y
L
D
FSG
GI
AVLNT
GH
L
HP
K
V
V
AAV
-
E
A
Q
LKKLS
H
TCFQVLAY
E
PY
L
E
L
C
E
I
M
NQKV
P
GDFAKK
T
LLVT
T
GSEA
V
E
N
A
V
K
I
AR
AATK-----
-
R
SGT
I
A
F
S
G
A
YHG
R
T
--------
HY
T
LA
L
TGKVNP
-
YSAGM
G
LM
P
G
H
VYRALYPCPLHGISEDDAIASIHRIFKN
D
AAPEDI
AAI
V
I
EPV
-
QG
E
GG
FYAAS
P
A
F
M
QR
LR
A
LCDE
H
GI
M
LI
A
DEV
QS
G
AG
RTG
T
LFA
MEQMGVA
PDL
T
T
F
AK
S
I
A
GG
-
F
PL
A
G
VT
G
R
AEVM
D
A
VA
PG
G
--
---L
G
G
T
YA
GNP
I
A
C
V
AA
L
E
V
L
KVFEQENLL
Q
KANDLGQ
K
L
K
D
G
L
LV
I
A
E
KHPEIG
DVRGLG
fig|656444.3.peg.4620
Escherichia coli TA280 (18-339/407)
LPIYA
P
A
EFI
PVK
G
Q
G
SR
I
W
D
Q
Q
G
KE
YVD
FAG
GI
AVTAL
GH
C
HP
A
L
V
N
A
L
-
K
T
Q
GETLW
H
IS-NVFTN
E
PA
L
R
L
G
R
K
L
---I
E
VTFAER
V
VFMN
SG
T
EA
N
E
T
A
F
KLAR
HYACVRHSP
FK
TKI
I
A
F
H
N
A
F
HG
R
S
--------
LF
T
V
S
V
GGQ-PK
-
YSDGF
G
PK
P
A
D
IIHVPF-NDLHAVKA-------------
-
VMDDHT
C
A
VV
V
EP
I
-
QG
E
GG
VTAAT
PE
F
L
QG
LR
E
LCD
Q
H
QA
LL
V
F
DEV
QC
G
MG
RTG
D
LFA
YMHYGVT
PD
I
L
T
S
AK
A
L
G
GG
-
F
P
I
S
A
ML
T
T
AE
IA
S
A
FH
PG
S
--
---H
G
S
T
YG
GNPLA
C
A
V
A
G
A
A
F
DIINTPEVL
E
GIQAKRQ
R
F
V
D
H
L
QK
I
D
Q
QYDVFS
D
I
RG
M
G
fig|656417.3.peg.4199
Escherichia coli M605 (18-339/406)
LPIYA
P
A
EFI
PVK
G
Q
G
SR
I
W
D
Q
Q
G
KE
YVD
FAG
GI
AVTAL
GH
C
HP
A
L
V
N
A
L
-
K
T
Q
GETLW
H
IS-NVFTN
E
PA
L
R
L
G
R
K
L
---I
E
ATFAER
V
VFMN
SG
T
EA
N
E
T
A
F
KLAR
HYACVRHSP
FK
TKI
I
A
F
H
N
A
F
HG
R
S
--------
LF
T
V
S
V
GGQ-PK
-
YSDGF
G
PK
P
A
D
IIHVPF-NDLHAVKA-------------
-
VMDDHT
C
A
VV
V
EP
I
-
QG
E
GG
VTAAT
PE
F
L
QG
LR
E
LCDE
H
QA
LL
V
F
DEV
QS
G
MG
RTG
D
LFA
YMHYGVT
PD
I
L
T
S
AK
A
L
G
GG
-
F
P
I
S
A
ML
T
T
AE
IA
S
A
FH
PG
S
--
---H
G
S
T
YG
GNPLA
C
A
V
A
G
A
A
F
DIINTPEVL
E
GIQAKRQ
R
F
V
D
H
L
QK
I
D
Q
QYDVFS
D
I
RG
M
G
fig|562.371.peg.3509
Escherichia coli 1044A (18-339/406)
LPIYA
P
A
EFI
PVK
G
Q
G
SR
I
W
D
Q
Q
G
KE
YVD
FAG
GI
AVTAL
GH
C
HP
A
L
V
N
A
L
-
K
T
Q
GETLW
H
IS-NVFTN
E
PA
L
R
L
G
R
K
L
---I
E
ATFAER
V
VFMN
SG
T
EA
N
E
T
A
F
KLAR
HYACVRHSP
FK
TKI
I
A
F
H
N
A
F
HG
R
S
--------
LF
T
V
S
V
GGQ-PK
-
YSDGF
G
PK
P
S
D
IIHVPF-NDLHAVKA-------------
-
VMDDHT
C
A
VV
V
EP
I
-
QG
E
GG
VTAAT
PE
F
L
QG
LR
E
LCD
Q
H
QA
LL
V
F
DEV
QC
G
MG
RTG
D
LFA
YMHYGVT
PD
I
L
T
S
AK
A
L
G
GG
-
F
P
I
S
A
ML
T
T
AE
IA
S
A
FH
PG
S
--
---H
G
S
T
YG
GNPLA
C
A
V
A
G
A
A
F
DIINTPEVL
E
GIQAKRQ
R
F
V
D
H
L
QK
I
D
Q
QYDVFS
D
I
RG
M
G
fig|562.373.peg.1334
Escherichia coli 1125A (18-339/406)
LPIYA
P
A
EFI
PVK
G
Q
G
SR
I
W
D
Q
Q
G
KE
YVD
FAG
GI
AVTAL
GH
C
HP
A
L
V
N
A
L
-
K
T
Q
GETLW
H
IS-NVFTN
E
PA
L
R
L
G
R
K
L
---I
E
ATFAER
V
VFMN
SG
T
EA
N
E
T
A
F
KLAR
HYACVRHSP
FK
TKI
I
A
F
H
N
A
F
HG
R
S
--------
LF
T
V
S
V
GGQ-PK
-
YSDGF
G
PK
P
S
D
IIHVPF-NDLHAVKA-------------
-
VMDDHT
C
A
VV
V
EP
I
-
QG
E
GG
VTAAT
PE
F
L
QG
LR
E
LCD
Q
H
QA
LL
V
F
DEV
QC
G
MG
RTG
D
LFA
YMHYGVT
PD
I
L
T
S
AK
A
L
G
GG
-
F
P
I
S
A
ML
T
T
AE
IA
S
A
FH
PG
S
--
---H
G
S
T
YG
GNPLA
C
A
V
A
G
A
A
F
DIINTPEVL
E
GIQAKRQ
R
F
V
D
H
L
QK
I
D
Q
QYDVFS
D
I
RG
M
G
fig|562.372.peg.4391
Escherichia coli 1212A (18-339/406)
LPIYA
P
A
EFI
PVK
G
Q
G
SR
I
W
D
Q
Q
G
KE
YVD
FAG
GI
AVTAL
GH
C
HP
A
L
V
N
A
L
-
K
T
Q
GETLW
H
IS-NVFTN
E
PA
L
R
L
G
R
K
L
---I
E
ATFAER
V
VFMN
SG
T
EA
N
E
T
A
F
KLAR
HYACVRHSP
FK
TKI
I
A
F
H
N
A
F
HG
R
S
--------
LF
T
V
S
V
GGQ-PK
-
YSDGF
G
PK
P
S
D
IIHVPF-NDLHAVKA-------------
-
VMDDHT
C
A
VV
V
EP
I
-
QG
E
GG
VTAAT
PE
F
L
QG
LR
E
LCD
Q
H
QA
LL
V
F
DEV
QC
G
MG
RTG
D
LFA
YMHYGVT
PD
I
L
T
S
AK
A
L
G
GG
-
F
P
I
S
A
ML
T
T
AE
IA
S
A
FH
PG
S
--
---H
G
S
T
YG
GNPLA
C
A
V
A
G
A
A
F
DIINTPEVL
E
GIQAKRQ
R
F
V
D
H
L
QK
I
D
Q
QYDVFS
D
I
RG
M
G
fig|562.374.peg.4927
Escherichia coli 536A (18-339/406)
LPIYA
P
A
EFI
PVK
G
Q
G
SR
I
W
D
Q
Q
G
KE
YVD
FAG
GI
AVTAL
GH
C
HP
A
L
V
N
A
L
-
K
T
Q
GETLW
H
IS-NVFTN
E
PA
L
R
L
G
R
K
L
---I
E
ATFAER
V
VFMN
SG
T
EA
N
E
T
A
F
KLAR
HYACVRHSP
FK
TKI
I
A
F
H
N
A
F
HG
R
S
--------
LF
T
V
S
V
GGQ-PK
-
YSDGF
G
PK
P
S
D
IIHVPF-NDLHAVKA-------------
-
VMDDHT
C
A
VV
V
EP
I
-
QG
E
GG
VTAAT
PE
F
L
QG
LR
E
LCD
Q
H
QA
LL
V
F
DEV
QC
G
MG
RTG
D
LFA
YMHYGVT
PD
I
L
T
S
AK
A
L
G
GG
-
F
P
I
S
A
ML
T
T
AE
IA
S
A
FH
PG
S
--
---H
G
S
T
YG
GNPLA
C
A
V
A
G
A
A
F
DIINTPEVL
E
GIQAKRQ
R
F
V
D
H
L
QK
I
D
Q
QYDVFS
D
I
RG
M
G
fig|83334.1.peg.4184
Escherichia coli O157:H7 (18-339/406)
LPIYA
P
A
EFI
PVK
G
Q
G
SR
I
W
D
Q
Q
G
KE
YVD
FAG
GI
AVTAL
GH
C
HP
A
L
V
N
A
L
-
K
T
Q
GETLW
H
IS-NVFTN
E
PA
L
R
L
G
R
K
L
---I
E
ATFAER
V
VFMN
SG
T
EA
N
E
T
A
F
KLAR
HYACVRHSP
FK
TKI
I
A
F
H
N
A
F
HG
R
S
--------
LF
T
V
S
V
GGQ-PK
-
YSDGF
G
PK
P
S
D
IIHVPF-NDLHAVKA-------------
-
VMDDHT
C
A
VV
V
EP
I
-
QG
E
GG
VTAAT
PE
F
L
QG
LR
E
LCD
Q
H
QA
LL
V
F
DEV
QC
G
MG
RTG
D
LFA
YMHYGVT
PD
I
L
T
S
AK
A
L
G
GG
-
F
P
I
S
A
ML
T
T
AE
IA
S
A
FH
PG
S
--
---H
G
S
T
YG
GNPLA
C
A
V
A
G
A
A
F
DIINTPEVL
E
GIQAKRQ
R
F
V
D
H
L
QK
I
D
Q
QYDVFS
D
I
RG
M
G
fig|155864.1.peg.4215
Escherichia coli O157:H7 EDL933 (18-339/406)
LPIYA
P
A
EFI
PVK
G
Q
G
SR
I
W
D
Q
Q
G
KE
YVD
FAG
GI
AVTAL
GH
C
HP
A
L
V
N
A
L
-
K
T
Q
GETLW
H
IS-NVFTN
E
PA
L
R
L
G
R
K
L
---I
E
ATFAER
V
VFMN
SG
T
EA
N
E
T
A
F
KLAR
HYACVRHSP
FK
TKI
I
A
F
H
N
A
F
HG
R
S
--------
LF
T
V
S
V
GGQ-PK
-
YSDGF
G
PK
P
S
D
IIHVPF-NDLHAVKA-------------
-
VMDDHT
C
A
VV
V
EP
I
-
QG
E
GG
VTAAT
PE
F
L
QG
LR
E
LCD
Q
H
QA
LL
V
F
DEV
QC
G
MG
RTG
D
LFA
YMHYGVT
PD
I
L
T
S
AK
A
L
G
GG
-
F
P
I
S
A
ML
T
T
AE
IA
S
A
FH
PG
S
--
---H
G
S
T
YG
GNPLA
C
A
V
A
G
A
A
F
DIINTPEVL
E
GIQAKRQ
R
F
V
D
H
L
QK
I
D
Q
QYDVFS
D
I
RG
M
G
fig|155864.8.peg.4152
Escherichia coli O157:H7 EDL933 (18-339/406)
LPIYA
P
A
EFI
PVK
G
Q
G
SR
I
W
D
Q
Q
G
KE
YVD
FAG
GI
AVTAL
GH
C
HP
A
L
V
N
A
L
-
K
T
Q
GETLW
H
IS-NVFTN
E
PA
L
R
L
G
R
K
L
---I
E
ATFAER
V
VFMN
SG
T
EA
N
E
T
A
F
KLAR
HYACVRHSP
FK
TKI
I
A
F
H
N
A
F
HG
R
S
--------
LF
T
V
S
V
GGQ-PK
-
YSDGF
G
PK
P
S
D
IIHVPF-NDLHAVKA-------------
-
VMDDHT
C
A
VV
V
EP
I
-
QG
E
GG
VTAAT
PE
F
L
QG
LR
E
LCD
Q
H
QA
LL
V
F
DEV
QC
G
MG
RTG
D
LFA
YMHYGVT
PD
I
L
T
S
AK
A
L
G
GG
-
F
P
I
S
A
ML
T
T
AE
IA
S
A
FH
PG
S
--
---H
G
S
T
YG
GNPLA
C
A
V
A
G
A
A
F
DIINTPEVL
E
GIQAKRQ
R
F
V
D
H
L
QK
I
D
Q
QYDVFS
D
I
RG
M
G
fig|444454.5.peg.3278
Escherichia coli O157:H7 str. EC4024 (18-339/406)
LPIYA
P
A
EFI
PVK
G
Q
G
SR
I
W
D
Q
Q
G
KE
YVD
FAG
GI
AVTAL
GH
C
HP
A
L
V
N
A
L
-
K
T
Q
GETLW
H
IS-NVFTN
E
PA
L
R
L
G
R
K
L
---I
E
ATFAER
V
VFMN
SG
T
EA
N
E
T
A
F
KLAR
HYACVRHSP
FK
TKI
I
A
F
H
N
A
F
HG
R
S
--------
LF
T
V
S
V
GGQ-PK
-
YSDGF
G
PK
P
S
D
IIHVPF-NDLHAVKA-------------
-
VMDDHT
C
A
VV
V
EP
I
-
QG
E
GG
VTAAT
PE
F
L
QG
LR
E
LCD
Q
H
QA
LL
V
F
DEV
QC
G
MG
RTG
D
LFA
YMHYGVT
PD
I
L
T
S
AK
A
L
G
GG
-
F
P
I
S
A
ML
T
T
AE
IA
S
A
FH
PG
S
--
---H
G
S
T
YG
GNPLA
C
A
V
A
G
A
A
F
DIINTPEVL
E
GIQAKRQ
R
F
V
D
H
L
QK
I
D
Q
QYDVFS
D
I
RG
M
G
fig|444449.5.peg.2734
Escherichia coli O157:H7 str. EC4042 (18-339/406)
LPIYA
P
A
EFI
PVK
G
Q
G
SR
I
W
D
Q
Q
G
KE
YVD
FAG
GI
AVTAL
GH
C
HP
A
L
V
N
A
L
-
K
T
Q
GETLW
H
IS-NVFTN
E
PA
L
R
L
G
R
K
L
---I
E
ATFAER
V
VFMN
SG
T
EA
N
E
T
A
F
KLAR
HYACVRHSP
FK
TKI
I
A
F
H
N
A
F
HG
R
S
--------
LF
T
V
S
V
GGQ-PK
-
YSDGF
G
PK
P
S
D
IIHVPF-NDLHAVKA-------------
-
VMDDHT
C
A
VV
V
EP
I
-
QG
E
GG
VTAAT
PE
F
L
QG
LR
E
LCD
Q
H
QA
LL
V
F
DEV
QC
G
MG
RTG
D
LFA
YMHYGVT
PD
I
L
T
S
AK
A
L
G
GG
-
F
P
I
S
A
ML
T
T
AE
IA
S
A
FH
PG
S
--
---H
G
S
T
YG
GNPLA
C
A
V
A
G
A
A
F
DIINTPEVL
E
GIQAKRQ
R
F
V
D
H
L
QK
I
D
Q
QYDVFS
D
I
RG
M
G
fig|444448.5.peg.1485
Escherichia coli O157:H7 str. EC4045 (18-339/406)
LPIYA
P
A
EFI
PVK
G
Q
G
SR
I
W
D
Q
Q
G
KE
YVD
FAG
GI
AVTAL
GH
C
HP
A
L
V
N
A
L
-
K
T
Q
GETLW
H
IS-NVFTN
E
PA
L
R
L
G
R
K
L
---I
E
ATFAER
V
VFMN
SG
T
EA
N
E
T
A
F
KLAR
HYACVRHSP
FK
TKI
I
A
F
H
N
A
F
HG
R
S
--------
LF
T
V
S
V
GGQ-PK
-
YSDGF
G
PK
P
S
D
IIHVPF-NDLHAVKA-------------
-
VMDDHT
C
A
VV
V
EP
I
-
QG
E
GG
VTAAT
PE
F
L
QG
LR
E
LCD
Q
H
QA
LL
V
F
DEV
QC
G
MG
RTG
D
LFA
YMHYGVT
PD
I
L
T
S
AK
A
L
G
GG
-
F
P
I
S
A
ML
T
T
AE
IA
S
A
FH
PG
S
--
---H
G
S
T
YG
GNPLA
C
A
V
A
G
A
A
F
DIINTPEVL
E
GIQAKRQ
R
F
V
D
H
L
QK
I
D
Q
QYDVFS
D
I
RG
M
G
fig|444453.5.peg.1018
Escherichia coli O157:H7 str. EC4076 (18-339/406)
LPIYA
P
A
EFI
PVK
G
Q
G
SR
I
W
D
Q
Q
G
KE
YVD
FAG
GI
AVTAL
GH
C
HP
A
L
V
N
A
L
-
K
T
Q
GETLW
H
IS-NVFTN
E
PA
L
R
L
G
R
K
L
---I
E
ATFAER
V
VFMN
SG
T
EA
N
E
T
A
F
KLAR
HYACVRHSP
FK
TKI
I
A
F
H
N
A
F
HG
R
S
--------
LF
T
V
S
V
GGQ-PK
-
YSDGF
G
PK
P
S
D
IIHVPF-NDLHAVKA-------------
-
VMDDHT
C
A
VV
V
EP
I
-
QG
E
GG
VTAAT
PE
F
L
QG
LR
E
LCD
Q
H
QA
LL
V
F
DEV
QC
G
MG
RTG
D
LFA
YMHYGVT
PD
I
L
T
S
AK
A
L
G
GG
-
F
P
I
S
A
ML
T
T
AE
IA
S
A
FH
PG
S
--
---H
G
S
T
YG
GNPLA
C
A
V
A
G
A
A
F
DIINTPEVL
E
GIQAKRQ
R
F
V
D
H
L
QK
I
D
Q
QYDVFS
D
I
RG
M
G
fig|444452.5.peg.4713
Escherichia coli O157:H7 str. EC4113 (18-339/406)
LPIYA
P
A
EFI
PVK
G
Q
G
SR
I
W
D
Q
Q
G
KE
YVD
FAG
GI
AVTAL
GH
C
HP
A
L
V
N
A
L
-
K
T
Q
GETLW
H
IS-NVFTN
E
PA
L
R
L
G
R
K
L
---I
E
ATFAER
V
VFMN
SG
T
EA
N
E
T
A
F
KLAR
HYACVRHSP
FK
TKI
I
A
F
H
N
A
F
HG
R
S
--------
LF
T
V
S
V
GGQ-PK
-
YSDGF
G
PK
P
S
D
IIHVPF-NDLHAVKA-------------
-
VMDDHT
C
A
VV
V
EP
I
-
QG
E
GG
VTAAT
PE
F
L
QG
LR
E
LCD
Q
H
QA
LL
V
F
DEV
QC
G
MG
RTG
D
LFA
YMHYGVT
PD
I
L
T
S
AK
A
L
G
GG
-
F
P
I
S
A
ML
T
T
AE
IA
S
A
FH
PG
S
--
---H
G
S
T
YG
GNPLA
C
A
V
A
G
A
A
F
DIINTPEVL
E
GIQAKRQ
R
F
V
D
H
L
QK
I
D
Q
QYDVFS
D
I
RG
M
G
fig|444450.8.peg.4567
Escherichia coli O157:H7 str. EC4115 (18-339/406)
LPIYA
P
A
EFI
PVK
G
Q
G
SR
I
W
D
Q
Q
G
KE
YVD
FAG
GI
AVTAL
GH
C
HP
A
L
V
N
A
L
-
K
T
Q
GETLW
H
IS-NVFTN
E
PA
L
R
L
G
R
K
L
---I
E
ATFAER
V
VFMN
SG
T
EA
N
E
T
A
F
KLAR
HYACVRHSP
FK
TKI
I
A
F
H
N
A
F
HG
R
S
--------
LF
T
V
S
V
GGQ-PK
-
YSDGF
G
PK
P
S
D
IIHVPF-NDLHAVKA-------------
-
VMDDHT
C
A
VV
V
EP
I
-
QG
E
GG
VTAAT
PE
F
L
QG
LR
E
LCD
Q
H
QA
LL
V
F
DEV
QC
G
MG
RTG
D
LFA
YMHYGVT
PD
I
L
T
S
AK
A
L
G
GG
-
F
P
I
S
A
ML
T
T
AE
IA
S
A
FH
PG
S
--
---H
G
S
T
YG
GNPLA
C
A
V
A
G
A
A
F
DIINTPEVL
E
GIQAKRQ
R
F
V
D
H
L
QK
I
D
Q
QYDVFS
D
I
RG
M
G
fig|444451.5.peg.498
Escherichia coli O157:H7 str. EC4196 (18-339/406)
LPIYA
P
A
EFI
PVK
G
Q
G
SR
I
W
D
Q
Q
G
KE
YVD
FAG
GI
AVTAL
GH
C
HP
A
L
V
N
A
L
-
K
T
Q
GETLW
H
IS-NVFTN
E
PA
L
R
L
G
R
K
L
---I
E
ATFAER
V
VFMN
SG
T
EA
N
E
T
A
F
KLAR
HYACVRHSP
FK
TKI
I
A
F
H
N
A
F
HG
R
S
--------
LF
T
V
S
V
GGQ-PK
-
YSDGF
G
PK
P
S
D
IIHVPF-NDLHAVKA-------------
-
VMDDHT
C
A
VV
V
EP
I
-
QG
E
GG
VTAAT
PE
F
L
QG
LR
E
LCD
Q
H
QA
LL
V
F
DEV
QC
G
MG
RTG
D
LFA
YMHYGVT
PD
I
L
T
S
AK
A
L
G
GG
-
F
P
I
S
A
ML
T
T
AE
IA
S
A
FH
PG
S
--
---H
G
S
T
YG
GNPLA
C
A
V
A
G
A
A
F
DIINTPEVL
E
GIQAKRQ
R
F
V
D
H
L
QK
I
D
Q
QYDVFS
D
I
RG
M
G
fig|444447.5.peg.1649
Escherichia coli O157:H7 str. EC4206 (18-339/406)
LPIYA
P
A
EFI
PVK
G
Q
G
SR
I
W
D
Q
Q
G
KE
YVD
FAG
GI
AVTAL
GH
C
HP
A
L
V
N
A
L
-
K
T
Q
GETLW
H
IS-NVFTN
E
PA
L
R
L
G
R
K
L
---I
E
ATFAER
V
VFMN
SG
T
EA
N
E
T
A
F
KLAR
HYACVRHSP
FK
TKI
I
A
F
H
N
A
F
HG
R
S
--------
LF
T
V
S
V
GGQ-PK
-
YSDGF
G
PK
P
S
D
IIHVPF-NDLHAVKA-------------
-
VMDDHT
C
A
VV
V
EP
I
-
QG
E
GG
VTAAT
PE
F
L
QG
LR
E
LCD
Q
H
QA
LL
V
F
DEV
QC
G
MG
RTG
D
LFA
YMHYGVT
PD
I
L
T
S
AK
A
L
G
GG
-
F
P
I
S
A
ML
T
T
AE
IA
S
A
FH
PG
S
--
---H
G
S
T
YG
GNPLA
C
A
V
A
G
A
A
F
DIINTPEVL
E
GIQAKRQ
R
F
V
D
H
L
QK
I
D
Q
QYDVFS
D
I
RG
M
G
fig|478004.5.peg.44
Escherichia coli O157:H7 str. EC4401 (18-339/406)
LPIYA
P
A
EFI
PVK
G
Q
G
SR
I
W
D
Q
Q
G
KE
YVD
FAG
GI
AVTAL
GH
C
HP
A
L
V
N
A
L
-
K
T
Q
GETLW
H
IS-NVFTN
E
PA
L
R
L
G
R
K
L
---I
E
ATFAER
V
VFMN
SG
T
EA
N
E
T
A
F
KLAR
HYACVRHSP
FK
TKI
I
A
F
H
N
A
F
HG
R
S
--------
LF
T
V
S
V
GGQ-PK
-
YSDGF
G
PK
P
S
D
IIHVPF-NDLHAVKA-------------
-
VMDDHT
C
A
VV
V
EP
I
-
QG
E
GG
VTAAT
PE
F
L
QG
LR
E
LCD
Q
H
QA
LL
V
F
DEV
QC
G
MG
RTG
D
LFA
YMHYGVT
PD
I
L
T
S
AK
A
L
G
GG
-
F
P
I
S
A
ML
T
T
AE
IA
S
A
FH
PG
S
--
---H
G
S
T
YG
GNPLA
C
A
V
A
G
A
A
F
DIINTPEVL
E
GIQAKRQ
R
F
V
D
H
L
QK
I
D
Q
QYDVFS
D
I
RG
M
G
fig|478005.5.peg.15
Escherichia coli O157:H7 str. EC4486 (18-339/406)
LPIYA
P
A
EFI
PVK
G
Q
G
SR
I
W
D
Q
Q
G
KE
YVD
FAG
GI
AVTAL
GH
C
HP
A
L
V
N
A
L
-
K
T
Q
GETLW
H
IS-NVFTN
E
PA
L
R
L
G
R
K
L
---I
E
ATFAER
V
VFMN
SG
T
EA
N
E
T
A
F
KLAR
HYACVRHSP
FK
TKI
I
A
F
H
N
A
F
HG
R
S
--------
LF
T
V
S
V
GGQ-PK
-
YSDGF
G
PK
P
S
D
IIHVPF-NDLHAVKA-------------
-
VMDDHT
C
A
VV
V
EP
I
-
QG
E
GG
VTAAT
PE
F
L
QG
LR
E
LCD
Q
H
QA
LL
V
F
DEV
QC
G
MG
RTG
D
LFA
YMHYGVT
PD
I
L
T
S
AK
A
L
G
GG
-
F
P
I
S
A
ML
T
T
AE
IA
S
A
FH
PG
S
--
---H
G
S
T
YG
GNPLA
C
A
V
A
G
A
A
F
DIINTPEVL
E
GIQAKRQ
R
F
V
D
H
L
QK
I
D
Q
QYDVFS
D
I
RG
M
G
fig|478006.5.peg.12
Escherichia coli O157:H7 str. EC4501 (18-339/406)
LPIYA
P
A
EFI
PVK
G
Q
G
SR
I
W
D
Q
Q
G
KE
YVD
FAG
GI
AVTAL
GH
C
HP
A
L
V
N
A
L
-
K
T
Q
GETLW
H
IS-NVFTN
E
PA
L
R
L
G
R
K
L
---I
E
ATFAER
V
VFMN
SG
T
EA
N
E
T
A
F
KLAR
HYACVRHSP
FK
TKI
I
A
F
H
N
A
F
HG
R
S
--------
LF
T
V
S
V
GGQ-PK
-
YSDGF
G
PK
P
S
D
IIHVPF-NDLHAVKA-------------
-
VMDDHT
C
A
VV
V
EP
I
-
QG
E
GG
VTAAT
PE
F
L
QG
LR
E
LCD
Q
H
QA
LL
V
F
DEV
QC
G
MG
RTG
D
LFA
YMHYGVT
PD
I
L
T
S
AK
A
L
G
GG
-
F
P
I
S
A
ML
T
T
AE
IA
S
A
FH
PG
S
--
---H
G
S
T
YG
GNPLA
C
A
V
A
G
A
A
F
DIINTPEVL
E
GIQAKRQ
R
F
V
D
H
L
QK
I
D
Q
QYDVFS
D
I
RG
M
G
fig|478007.5.peg.15
Escherichia coli O157:H7 str. EC508 (18-339/406)
LPIYA
P
A
EFI
PVK
G
Q
G
SR
I
W
D
Q
Q
G
KE
YVD
FAG
GI
AVTAL
GH
C
HP
A
L
V
N
A
L
-
K
T
Q
GETLW
H
IS-NVFTN
E
PA
L
R
L
G
R
K
L
---I
E
ATFAER
V
VFMN
SG
T
EA
N
E
T
A
F
KLAR
HYACVRHSP
FK
TKI
I
A
F
H
N
A
F
HG
R
S
--------
LF
T
V
S
V
GGQ-PK
-
YSDGF
G
PK
P
S
D
IIHVPF-NDLHAVKA-------------
-
VMDDHT
C
A
VV
V
EP
I
-
QG
E
GG
VTAAT
PE
F
L
QG
LR
E
LCD
Q
H
QA
LL
V
F
DEV
QC
G
MG
RTG
D
LFA
YMHYGVT
PD
I
L
T
S
AK
A
L
G
GG
-
F
P
I
S
A
ML
T
T
AE
IA
S
A
FH
PG
S
--
---H
G
S
T
YG
GNPLA
C
A
V
A
G
A
A
F
DIINTPEVL
E
GIQAKRQ
R
F
V
D
H
L
QK
I
D
Q
QYDVFS
D
I
RG
M
G
fig|478008.5.peg.539
Escherichia coli O157:H7 str. EC869 (18-339/406)
LPIYA
P
A
EFI
PVK
G
Q
G
SR
I
W
D
Q
Q
G
KE
YVD
FAG
GI
AVTAL
GH
C
HP
A
L
V
N
A
L
-
K
T
Q
GETLW
H
IS-NVFTN
E
PA
L
R
L
G
R
K
L
---I
E
ATFAER
V
VFMN
SG
T
EA
N
E
T
A
F
KLAR
HYACVRHSP
FK
TKI
I
A
F
H
N
A
F
HG
R
S
--------
LF
T
V
S
V
GGQ-PK
-
YSDGF
G
PK
P
S
D
IIHVPF-NDLHAVKA-------------
-
VMDDHT
C
A
VV
V
EP
I
-
QG
E
GG
VTAAT
PE
F
L
QG
LR
E
LCD
Q
H
QA
LL
V
F
DEV
QC
G
MG
RTG
D
LFA
YMHYGVT
PD
I
L
T
S
AK
A
L
G
GG
-
F
P
I
S
A
ML
T
T
AE
IA
S
A
FH
PG
S
--
---H
G
S
T
YG
GNPLA
C
A
V
A
G
A
A
F
DIINTPEVL
E
GIQAKRQ
R
F
V
D
H
L
QK
I
D
Q
QYDVFS
D
I
RG
M
G
fig|637388.3.peg.1732
Escherichia coli O157:H7 str. FRIK2000 (18-339/406)
LPIYA
P
A
EFI
PVK
G
Q
G
SR
I
W
D
Q
Q
G
KE
YVD
FAG
GI
AVTAL
GH
C
HP
A
L
V
N
A
L
-
K
T
Q
GETLW
H
IS-NVFTN
E
PA
L
R
L
G
R
K
L
---I
E
ATFAER
V
VFMN
SG
T
EA
N
E
T
A
F
KLAR
HYACVRHSP
FK
TKI
I
A
F
H
N
A
F
HG
R
S
--------
LF
T
V
S
V
GGQ-PK
-
YSDGF
G
PK
P
S
D
IIHVPF-NDLHAVKA-------------
-
VMDDHT
C
A
VV
V
EP
I
-
QG
E
GG
VTAAT
PE
F
L
QG
LR
E
LCD
Q
H
QA
LL
V
F
DEV
QC
G
MG
RTG
D
LFA
YMHYGVT
PD
I
L
T
S
AK
A
L
G
GG
-
F
P
I
S
A
ML
T
T
AE
IA
S
A
FH
PG
S
--
---H
G
S
T
YG
GNPLA
C
A
V
A
G
A
A
F
DIINTPEVL
E
GIQAKRQ
R
F
V
D
H
L
QK
I
D
Q
QYDVFS
D
I
RG
M
G
fig|570506.3.peg.288
Escherichia coli O157:H7 str. FRIK966 (18-339/406)
LPIYA
P
A
EFI
PVK
G
Q
G
SR
I
W
D
Q
Q
G
KE
YVD
FAG
GI
AVTAL
GH
C
HP
A
L
V
N
A
L
-
K
T
Q
GETLW
H
IS-NVFTN
E
PA
L
R
L
G
R
K
L
---I
E
ATFAER
V
VFMN
SG
T
EA
N
E
T
A
F
KLAR
HYACVRHSP
FK
TKI
I
A
F
H
N
A
F
HG
R
S
--------
LF
T
V
S
V
GGQ-PK
-
YSDGF
G
PK
P
S
D
IIHVPF-NDLHAVKA-------------
-
VMDDHT
C
A
VV
V
EP
I
-
QG
E
GG
VTAAT
PE
F
L
QG
LR
E
LCD
Q
H
QA
LL
V
F
DEV
QC
G
MG
RTG
D
LFA
YMHYGVT
PD
I
L
T
S
AK
A
L
G
GG
-
F
P
I
S
A
ML
T
T
AE
IA
S
A
FH
PG
S
--
---H
G
S
T
YG
GNPLA
C
A
V
A
G
A
A
F
DIINTPEVL
E
GIQAKRQ
R
F
V
D
H
L
QK
I
D
Q
QYDVFS
D
I
RG
M
G
fig|386585.9.peg.4394
Escherichia coli O157:H7 str. Sakai (18-339/406)
LPIYA
P
A
EFI
PVK
G
Q
G
SR
I
W
D
Q
Q
G
KE
YVD
FAG
GI
AVTAL
GH
C
HP
A
L
V
N
A
L
-
K
T
Q
GETLW
H
IS-NVFTN
E
PA
L
R
L
G
R
K
L
---I
E
ATFAER
V
VFMN
SG
T
EA
N
E
T
A
F
KLAR
HYACVRHSP
FK
TKI
I
A
F
H
N
A
F
HG
R
S
--------
LF
T
V
S
V
GGQ-PK
-
YSDGF
G
PK
P
S
D
IIHVPF-NDLHAVKA-------------
-
VMDDHT
C
A
VV
V
EP
I
-
QG
E
GG
VTAAT
PE
F
L
QG
LR
E
LCD
Q
H
QA
LL
V
F
DEV
QC
G
MG
RTG
D
LFA
YMHYGVT
PD
I
L
T
S
AK
A
L
G
GG
-
F
P
I
S
A
ML
T
T
AE
IA
S
A
FH
PG
S
--
---H
G
S
T
YG
GNPLA
C
A
V
A
G
A
A
F
DIINTPEVL
E
GIQAKRQ
R
F
V
D
H
L
QK
I
D
Q
QYDVFS
D
I
RG
M
G
fig|544404.4.peg.4378
Escherichia coli O157:H7 str. TW14359 (18-339/406)
LPIYA
P
A
EFI
PVK
G
Q
G
SR
I
W
D
Q
Q
G
KE
YVD
FAG
GI
AVTAL
GH
C
HP
A
L
V
N
A
L
-
K
T
Q
GETLW
H
IS-NVFTN
E
PA
L
R
L
G
R
K
L
---I
E
ATFAER
V
VFMN
SG
T
EA
N
E
T
A
F
KLAR
HYACVRHSP
FK
TKI
I
A
F
H
N
A
F
HG
R
S
--------
LF
T
V
S
V
GGQ-PK
-
YSDGF
G
PK
P
S
D
IIHVPF-NDLHAVKA-------------
-
VMDDHT
C
A
VV
V
EP
I
-
QG
E
GG
VTAAT
PE
F
L
QG
LR
E
LCD
Q
H
QA
LL
V
F
DEV
QC
G
MG
RTG
D
LFA
YMHYGVT
PD
I
L
T
S
AK
A
L
G
GG
-
F
P
I
S
A
ML
T
T
AE
IA
S
A
FH
PG
S
--
---H
G
S
T
YG
GNPLA
C
A
V
A
G
A
A
F
DIINTPEVL
E
GIQAKRQ
R
F
V
D
H
L
QK
I
D
Q
QYDVFS
D
I
RG
M
G
fig|502346.5.peg.2446
Escherichia coli O157:H7 str. TW14588 (18-339/406)
LPIYA
P
A
EFI
PVK
G
Q
G
SR
I
W
D
Q
Q
G
KE
YVD
FAG
GI
AVTAL
GH
C
HP
A
L
V
N
A
L
-
K
T
Q
GETLW
H
IS-NVFTN
E
PA
L
R
L
G
R
K
L
---I
E
ATFAER
V
VFMN
SG
T
EA
N
E
T
A
F
KLAR
HYACVRHSP
FK
TKI
I
A
F
H
N
A
F
HG
R
S
--------
LF
T
V
S
V
GGQ-PK
-
YSDGF
G
PK
P
S
D
IIHVPF-NDLHAVKA-------------
-
VMDDHT
C
A
VV
V
EP
I
-
QG
E
GG
VTAAT
PE
F
L
QG
LR
E
LCD
Q
H
QA
LL
V
F
DEV
QC
G
MG
RTG
D
LFA
YMHYGVT
PD
I
L
T
S
AK
A
L
G
GG
-
F
P
I
S
A
ML
T
T
AE
IA
S
A
FH
PG
S
--
---H
G
S
T
YG
GNPLA
C
A
V
A
G
A
A
F
DIINTPEVL
E
GIQAKRQ
R
F
V
D
H
L
QK
I
D
Q
QYDVFS
D
I
RG
M
G
fig|701177.3.peg.4076
Escherichia coli O55:H7 str. CB9615 (18-339/406)
LPIYA
P
A
EFI
PVK
G
Q
G
SR
I
W
D
Q
Q
G
KE
YVD
FAG
GI
AVTAL
GH
C
HP
A
L
V
N
A
L
-
K
T
Q
GETLW
H
IS-NVFTN
E
PA
L
R
L
G
R
K
L
---I
E
ATFAER
V
VFMN
SG
T
EA
N
E
T
A
F
KLAR
HYACVRHSP
FK
TKI
I
A
F
H
N
A
F
HG
R
S
--------
LF
T
V
S
V
GGQ-PK
-
YSDGF
G
PK
P
S
D
IIHVPF-NDLHAVKA-------------
-
VMDDHT
C
A
VV
V
EP
I
-
QG
E
GG
VTAAT
PE
F
L
QG
LR
E
LCD
Q
H
QA
LL
V
F
DEV
QC
G
MG
RTG
D
LFA
YMHYGVT
PD
I
L
T
S
AK
A
L
G
GG
-
F
P
I
S
A
ML
T
T
AE
IA
S
A
FH
PG
S
--
---H
G
S
T
YG
GNPLA
C
A
V
A
G
A
A
F
DIINTPEVL
E
GIQAKRQ
R
F
V
D
H
L
QK
I
D
Q
QYDVFS
D
I
RG
M
G
fig|362663.8.peg.3477
Escherichia coli 536 (18-339/406)
LPIYA
P
A
EFI
PVK
G
Q
G
SR
I
W
D
Q
Q
G
KE
YVD
FAG
GI
AVTAL
GH
C
HP
A
L
V
N
A
L
-
K
T
Q
GETLW
H
IS-NVFTN
E
PA
L
R
L
G
R
K
L
---I
E
ATFAER
V
VFMN
SG
T
EA
N
E
T
A
F
KLAR
HYACVRHSP
FK
TKI
I
A
F
H
N
A
F
HG
R
S
--------
LF
T
V
S
V
GGQ-PK
-
YSDGF
G
PK
P
A
D
IIHVPF-NDLHAVKA-------------
-
VMDDHT
C
A
VV
V
EP
I
-
QG
E
GG
VTAAT
PE
F
L
QG
LR
E
LCD
Q
H
QA
LL
V
F
DEV
QS
G
MG
RTG
D
LFA
YMHYCVT
PD
I
L
T
S
AK
A
L
G
GG
-
F
P
V
S
A
ML
T
T
AE
IA
S
A
FH
PG
S
--
---H
G
S
T
YG
GNPLA
C
A
V
A
G
A
A
F
DIINTPEVL
E
GIQAKRQ
R
F
V
D
H
L
QK
I
D
Q
QYDVFS
D
I
RG
M
G
fig|362663.9.peg.3489
Escherichia coli 536 (18-339/406)
LPIYA
P
A
EFI
PVK
G
Q
G
SR
I
W
D
Q
Q
G
KE
YVD
FAG
GI
AVTAL
GH
C
HP
A
L
V
N
A
L
-
K
T
Q
GETLW
H
IS-NVFTN
E
PA
L
R
L
G
R
K
L
---I
E
ATFAER
V
VFMN
SG
T
EA
N
E
T
A
F
KLAR
HYACVRHSP
FK
TKI
I
A
F
H
N
A
F
HG
R
S
--------
LF
T
V
S
V
GGQ-PK
-
YSDGF
G
PK
P
A
D
IIHVPF-NDLHAVKA-------------
-
VMDDHT
C
A
VV
V
EP
I
-
QG
E
GG
VTAAT
PE
F
L
QG
LR
E
LCD
Q
H
QA
LL
V
F
DEV
QS
G
MG
RTG
D
LFA
YMHYCVT
PD
I
L
T
S
AK
A
L
G
GG
-
F
P
V
S
A
ML
T
T
AE
IA
S
A
FH
PG
S
--
---H
G
S
T
YG
GNPLA
C
A
V
A
G
A
A
F
DIINTPEVL
E
GIQAKRQ
R
F
V
D
H
L
QK
I
D
Q
QYDVFS
D
I
RG
M
G
fig|340197.3.peg.1671
Escherichia coli F11 (18-339/406)
LPIYA
P
A
EFI
PVK
G
Q
G
SR
I
W
D
Q
Q
G
KE
YVD
FAG
GI
AVTAL
GH
C
HP
A
L
V
N
A
L
-
K
T
Q
GETLW
H
IS-NVFTN
E
PA
L
R
L
G
R
K
L
---I
E
ATFAER
V
VFMN
SG
T
EA
N
E
T
A
F
KLAR
HYACVRHSP
FK
TKI
I
A
F
H
N
A
F
HG
R
S
--------
LF
T
V
S
V
GGQ-PK
-
YSDGF
G
PK
P
A
D
IIHVPF-NDLHAVKA-------------
-
VMDDHT
C
A
VV
V
EP
I
-
QG
E
GG
VTAAT
PE
F
L
QG
LR
E
LCD
Q
H
QA
LL
V
F
DEV
QS
G
MG
RTG
D
LFA
YMHYCVT
PD
I
L
T
S
AK
A
L
G
GG
-
F
P
V
S
A
ML
T
T
AE
IA
S
A
FH
PG
S
--
---H
G
S
T
YG
GNPLA
C
A
V
A
G
A
A
F
DIINTPEVL
E
GIQAKRQ
R
F
V
D
H
L
QK
I
D
Q
QYDVFS
D
I
RG
M
G
fig|340197.5.peg.1763
Escherichia coli F11 (18-339/406)
LPIYA
P
A
EFI
PVK
G
Q
G
SR
I
W
D
Q
Q
G
KE
YVD
FAG
GI
AVTAL
GH
C
HP
A
L
V
N
A
L
-
K
T
Q
GETLW
H
IS-NVFTN
E
PA
L
R
L
G
R
K
L
---I
E
ATFAER
V
VFMN
SG
T
EA
N
E
T
A
F
KLAR
HYACVRHSP
FK
TKI
I
A
F
H
N
A
F
HG
R
S
--------
LF
T
V
S
V
GGQ-PK
-
YSDGF
G
PK
P
A
D
IIHVPF-NDLHAVKA-------------
-
VMDDHT
C
A
VV
V
EP
I
-
QG
E
GG
VTAAT
PE
F
L
QG
LR
E
LCD
Q
H
QA
LL
V
F
DEV
QS
G
MG
RTG
D
LFA
YMHYCVT
PD
I
L
T
S
AK
A
L
G
GG
-
F
P
V
S
A
ML
T
T
AE
IA
S
A
FH
PG
S
--
---H
G
S
T
YG
GNPLA
C
A
V
A
G
A
A
F
DIINTPEVL
E
GIQAKRQ
R
F
V
D
H
L
QK
I
D
Q
QYDVFS
D
I
RG
M
G
fig|749550.3.peg.2959
Escherichia coli MS 200-1 (18-339/406)
LPIYA
P
A
EFI
PVK
G
Q
G
SR
I
W
D
Q
Q
G
KE
YVD
FAG
GI
AVTAL
GH
C
HP
A
L
V
N
A
L
-
K
T
Q
GETLW
H
IS-NVFTN
E
PA
L
R
L
G
R
K
L
---I
E
ATFAER
V
VFMN
SG
T
EA
N
E
T
A
F
KLAR
HYACVRHSP
FK
TKI
I
A
F
H
N
A
F
HG
R
S
--------
LF
T
V
S
V
GGQ-PK
-
YSDGF
G
PK
P
A
D
IIHVPF-NDLHAVKA-------------
-
VMDDHT
C
A
VV
V
EP
I
-
QG
E
GG
VTAAT
PE
F
L
QG
LR
E
LCD
Q
H
QA
LL
V
F
DEV
QS
G
MG
RTG
D
LFA
YMHYCVT
PD
I
L
T
S
AK
A
L
G
GG
-
F
P
V
S
A
ML
T
T
AE
IA
S
A
FH
PG
S
--
---H
G
S
T
YG
GNPLA
C
A
V
A
G
A
A
F
DIINTPEVL
E
GIQAKRQ
R
F
V
D
H
L
QK
I
D
Q
QYDVFS
D
I
RG
M
G
fig|685038.3.peg.3397
Escherichia coli O83:H1 str. NRG 857C (18-339/406)
LPIYA
P
A
EFI
PVK
G
Q
G
SR
I
W
D
Q
Q
G
KE
YVD
FAG
GI
AVTAL
GH
C
HP
A
L
V
N
A
L
-
K
T
Q
GETLW
H
IS-NVFTN
E
PA
L
R
L
G
R
K
L
---I
E
ATFAER
V
VFMN
SG
T
EA
N
E
T
A
F
KLAR
HYACVRHSP
FK
TKI
I
A
F
H
N
A
F
HG
R
S
--------
LF
T
V
S
V
GGQ-PK
-
YSDGF
G
PK
P
A
D
IIHVPF-NDLHAVKA-------------
-
VMDDHT
C
A
VV
V
EP
I
-
QG
E
GG
VTAAT
PE
F
L
QG
LR
E
LCD
Q
H
QA
LL
V
F
DEV
QS
G
MG
RTG
D
LFA
YMHYCVT
PD
I
L
T
S
AK
A
L
G
GG
-
F
P
V
S
A
ML
T
T
AE
IA
S
A
FH
PG
S
--
---H
G
S
T
YG
GNPLA
C
A
V
A
G
A
A
F
DIINTPEVL
E
GIQAKRQ
R
F
V
D
H
L
QK
I
D
Q
QYDVFS
D
I
RG
M
G
fig|1040638.4.peg.1927
Escherichia coli O104:H4 str. LB226692 (18-339/406)
LPIYA
P
A
EFI
PVK
G
Q
G
SR
I
W
D
Q
Q
G
KE
YVD
FAG
GI
AVTAL
GH
C
HP
A
L
V
N
A
L
-
K
T
Q
GETLW
H
IS-NVFTN
E
PA
L
R
L
G
R
K
L
---I
E
ATFAER
V
VFMN
SG
T
EA
N
E
T
A
F
KLAR
HYACVRHSP
FK
TKI
I
A
F
H
N
A
F
HG
R
S
--------
LF
T
V
S
V
GGQ-PK
-
YSDGF
G
PK
P
A
D
IIHVPF-NDLHAVKA-------------
-
VMDDHT
C
A
VV
V
EP
I
-
QG
E
GG
VTAAT
PE
F
L
QG
LR
E
LCD
Q
H
QA
LL
V
F
DEV
QC
G
MG
RTG
D
LFA
YMHYGVT
PD
I
L
T
S
AK
A
L
G
GG
-
F
P
I
S
A
ML
T
T
AE
IA
S
A
FH
PG
S
--
---H
G
S
T
YG
GNPLA
C
A
V
A
G
A
A
F
DIINTPEVL
E
GIQAKRQ
R
F
V
D
H
L
QK
I
D
Q
QYDVFS
D
I
RG
M
G
fig|6666666.5357.peg.1238
Escherichia coli TY-2482 (18-339/406)
LPIYA
P
A
EFI
PVK
G
Q
G
SR
I
W
D
Q
Q
G
KE
YVD
FAG
GI
AVTAL
GH
C
HP
A
L
V
N
A
L
-
K
T
Q
GETLW
H
IS-NVFTN
E
PA
L
R
L
G
R
K
L
---I
E
ATFAER
V
VFMN
SG
T
EA
N
E
T
A
F
KLAR
HYACVRHSP
FK
TKI
I
A
F
H
N
A
F
HG
R
S
--------
LF
T
V
S
V
GGQ-PK
-
YSDGF
G
PK
P
A
D
IIHVPF-NDLHAVKA-------------
-
VMDDHT
C
A
VV
V
EP
I
-
QG
E
GG
VTAAT
PE
F
L
QG
LR
E
LCD
Q
H
QA
LL
V
F
DEV
QC
G
MG
RTG
D
LFA
YMHYGVT
PD
I
L
T
S
AK
A
L
G
GG
-
F
P
I
S
A
ML
T
T
AE
IA
S
A
FH
PG
S
--
---H
G
S
T
YG
GNPLA
C
A
V
A
G
A
A
F
DIINTPEVL
E
GIQAKRQ
R
F
V
D
H
L
QK
I
D
Q
QYDVFS
D
I
RG
M
G
fig|358709.5.peg.4242
Escherichia coli 101-1 (18-339/406)
LPIYA
P
A
EFI
PVK
G
Q
G
SR
I
W
D
Q
Q
G
KE
YVD
FAG
GI
AVTAL
GH
C
HP
A
L
V
N
A
L
-
K
T
Q
GETLW
H
IS-NVFTN
E
PA
L
R
L
G
R
K
L
---I
E
ATFAER
V
VFMN
SG
T
EA
N
E
T
A
F
KLAR
HYACVRHSP
FK
TKI
I
A
F
H
N
A
F
HG
R
S
--------
LF
T
V
S
V
GGQ-PK
-
YSDGF
G
PK
P
A
D
IIHVPF-NDLHAVKA-------------
-
VMDDHT
C
A
VV
V
EP
I
-
QG
E
GG
VTAAT
PE
F
L
QG
LR
E
LCD
Q
H
QA
LL
V
F
DEV
QC
G
MG
RTG
D
LFA
YMHYGVT
PD
I
L
T
S
AK
A
L
G
GG
-
F
P
I
S
A
ML
T
T
AE
IA
S
A
FH
PG
S
--
---H
G
S
T
YG
GNPLA
C
A
V
A
G
A
A
F
DIINTPEVL
E
GIQAKRQ
R
F
V
D
H
L
QK
I
D
Q
QYDVFS
D
I
RG
M
G
fig|344610.3.peg.249
Escherichia coli 53638 (18-339/406)
LPIYA
P
A
EFI
PVK
G
Q
G
SR
I
W
D
Q
Q
G
KE
YVD
FAG
GI
AVTAL
GH
C
HP
A
L
V
N
A
L
-
K
T
Q
GETLW
H
IS-NVFTN
E
PA
L
R
L
G
R
K
L
---I
E
ATFAER
V
VFMN
SG
T
EA
N
E
T
A
F
KLAR
HYACVRHSP
FK
TKI
I
A
F
H
N
A
F
HG
R
S
--------
LF
T
V
S
V
GGQ-PK
-
YSDGF
G
PK
P
A
D
IIHVPF-NDLHAVKA-------------
-
VMDDHT
C
A
VV
V
EP
I
-
QG
E
GG
VTAAT
PE
F
L
QG
LR
E
LCD
Q
H
QA
LL
V
F
DEV
QC
G
MG
RTG
D
LFA
YMHYGVT
PD
I
L
T
S
AK
A
L
G
GG
-
F
P
I
S
A
ML
T
T
AE
IA
S
A
FH
PG
S
--
---H
G
S
T
YG
GNPLA
C
A
V
A
G
A
A
F
DIINTPEVL
E
GIQAKRQ
R
F
V
D
H
L
QK
I
D
Q
QYDVFS
D
I
RG
M
G
fig|344610.7.peg.2881
Escherichia coli 53638 (18-339/406)
LPIYA
P
A
EFI
PVK
G
Q
G
SR
I
W
D
Q
Q
G
KE
YVD
FAG
GI
AVTAL
GH
C
HP
A
L
V
N
A
L
-
K
T
Q
GETLW
H
IS-NVFTN
E
PA
L
R
L
G
R
K
L
---I
E
ATFAER
V
VFMN
SG
T
EA
N
E
T
A
F
KLAR
HYACVRHSP
FK
TKI
I
A
F
H
N
A
F
HG
R
S
--------
LF
T
V
S
V
GGQ-PK
-
YSDGF
G
PK
P
A
D
IIHVPF-NDLHAVKA-------------
-
VMDDHT
C
A
VV
V
EP
I
-
QG
E
GG
VTAAT
PE
F
L
QG
LR
E
LCD
Q
H
QA
LL
V
F
DEV
QC
G
MG
RTG
D
LFA
YMHYGVT
PD
I
L
T
S
AK
A
L
G
GG
-
F
P
I
S
A
ML
T
T
AE
IA
S
A
FH
PG
S
--
---H
G
S
T
YG
GNPLA
C
A
V
A
G
A
A
F
DIINTPEVL
E
GIQAKRQ
R
F
V
D
H
L
QK
I
D
Q
QYDVFS
D
I
RG
M
G
fig|585055.6.peg.3791
Escherichia coli 55989 (18-339/406)
LPIYA
P
A
EFI
PVK
G
Q
G
SR
I
W
D
Q
Q
G
KE
YVD
FAG
GI
AVTAL
GH
C
HP
A
L
V
N
A
L
-
K
T
Q
GETLW
H
IS-NVFTN
E
PA
L
R
L
G
R
K
L
---I
E
ATFAER
V
VFMN
SG
T
EA
N
E
T
A
F
KLAR
HYACVRHSP
FK
TKI
I
A
F
H
N
A
F
HG
R
S
--------
LF
T
V
S
V
GGQ-PK
-
YSDGF
G
PK
P
A
D
IIHVPF-NDLHAVKA-------------
-
VMDDHT
C
A
VV
V
EP
I
-
QG
E
GG
VTAAT
PE
F
L
QG
LR
E
LCD
Q
H
QA
LL
V
F
DEV
QC
G
MG
RTG
D
LFA
YMHYGVT
PD
I
L
T
S
AK
A
L
G
GG
-
F
P
I
S
A
ML
T
T
AE
IA
S
A
FH
PG
S
--
---H
G
S
T
YG
GNPLA
C
A
V
A
G
A
A
F
DIINTPEVL
E
GIQAKRQ
R
F
V
D
H
L
QK
I
D
Q
QYDVFS
D
I
RG
M
G
fig|585055.8.peg.3793
Escherichia coli 55989 (18-339/406)
LPIYA
P
A
EFI
PVK
G
Q
G
SR
I
W
D
Q
Q
G
KE
YVD
FAG
GI
AVTAL
GH
C
HP
A
L
V
N
A
L
-
K
T
Q
GETLW
H
IS-NVFTN
E
PA
L
R
L
G
R
K
L
---I
E
ATFAER
V
VFMN
SG
T
EA
N
E
T
A
F
KLAR
HYACVRHSP
FK
TKI
I
A
F
H
N
A
F
HG
R
S
--------
LF
T
V
S
V
GGQ-PK
-
YSDGF
G
PK
P
A
D
IIHVPF-NDLHAVKA-------------
-
VMDDHT
C
A
VV
V
EP
I
-
QG
E
GG
VTAAT
PE
F
L
QG
LR
E
LCD
Q
H
QA
LL
V
F
DEV
QC
G
MG
RTG
D
LFA
YMHYGVT
PD
I
L
T
S
AK
A
L
G
GG
-
F
P
I
S
A
ML
T
T
AE
IA
S
A
FH
PG
S
--
---H
G
S
T
YG
GNPLA
C
A
V
A
G
A
A
F
DIINTPEVL
E
GIQAKRQ
R
F
V
D
H
L
QK
I
D
Q
QYDVFS
D
I
RG
M
G
fig|481805.3.peg.375
Escherichia coli ATCC 8739 (18-339/406)
LPIYA
P
A
EFI
PVK
G
Q
G
SR
I
W
D
Q
Q
G
KE
YVD
FAG
GI
AVTAL
GH
C
HP
A
L
V
N
A
L
-
K
T
Q
GETLW
H
IS-NVFTN
E
PA
L
R
L
G
R
K
L
---I
E
ATFAER
V
VFMN
SG
T
EA
N
E
T
A
F
KLAR
HYACVRHSP
FK
TKI
I
A
F
H
N
A
F
HG
R
S
--------
LF
T
V
S
V
GGQ-PK
-
YSDGF
G
PK
P
A
D
IIHVPF-NDLHAVKA-------------
-
VMDDHT
C
A
VV
V
EP
I
-
QG
E
GG
VTAAT
PE
F
L
QG
LR
E
LCD
Q
H
QA
LL
V
F
DEV
QC
G
MG
RTG
D
LFA
YMHYGVT
PD
I
L
T
S
AK
A
L
G
GG
-
F
P
I
S
A
ML
T
T
AE
IA
S
A
FH
PG
S
--
---H
G
S
T
YG
GNPLA
C
A
V
A
G
A
A
F
DIINTPEVL
E
GIQAKRQ
R
F
V
D
H
L
QK
I
D
Q
QYDVFS
D
I
RG
M
G
fig|481805.6.peg.381
Escherichia coli ATCC 8739 (18-339/406)
LPIYA
P
A
EFI
PVK
G
Q
G
SR
I
W
D
Q
Q
G
KE
YVD
FAG
GI
AVTAL
GH
C
HP
A
L
V
N
A
L
-
K
T
Q
GETLW
H
IS-NVFTN
E
PA
L
R
L
G
R
K
L
---I
E
ATFAER
V
VFMN
SG
T
EA
N
E
T
A
F
KLAR
HYACVRHSP
FK
TKI
I
A
F
H
N
A
F
HG
R
S
--------
LF
T
V
S
V
GGQ-PK
-
YSDGF
G
PK
P
A
D
IIHVPF-NDLHAVKA-------------
-
VMDDHT
C
A
VV
V
EP
I
-
QG
E
GG
VTAAT
PE
F
L
QG
LR
E
LCD
Q
H
QA
LL
V
F
DEV
QC
G
MG
RTG
D
LFA
YMHYGVT
PD
I
L
T
S
AK
A
L
G
GG
-
F
P
I
S
A
ML
T
T
AE
IA
S
A
FH
PG
S
--
---H
G
S
T
YG
GNPLA
C
A
V
A
G
A
A
F
DIINTPEVL
E
GIQAKRQ
R
F
V
D
H
L
QK
I
D
Q
QYDVFS
D
I
RG
M
G
fig|413997.3.peg.3359
Escherichia coli B str. REL606 (18-339/406)
LPIYA
P
A
EFI
PVK
G
Q
G
SR
I
W
D
Q
Q
G
KE
YVD
FAG
GI
AVTAL
GH
C
HP
A
L
V
N
A
L
-
K
T
Q
GETLW
H
IS-NVFTN
E
PA
L
R
L
G
R
K
L
---I
E
ATFAER
V
VFMN
SG
T
EA
N
E
T
A
F
KLAR
HYACVRHSP
FK
TKI
I
A
F
H
N
A
F
HG
R
S
--------
LF
T
V
S
V
GGQ-PK
-
YSDGF
G
PK
P
A
D
IIHVPF-NDLHAVKA-------------
-
VMDDHT
C
A
VV
V
EP
I
-
QG
E
GG
VTAAT
PE
F
L
QG
LR
E
LCD
Q
H
QA
LL
V
F
DEV
QC
G
MG
RTG
D
LFA
YMHYGVT
PD
I
L
T
S
AK
A
L
G
GG
-
F
P
I
S
A
ML
T
T
AE
IA
S
A
FH
PG
S
--
---H
G
S
T
YG
GNPLA
C
A
V
A
G
A
A
F
DIINTPEVL
E
GIQAKRQ
R
F
V
D
H
L
QK
I
D
Q
QYDVFS
D
I
RG
M
G
fig|550672.3.peg.3400
Escherichia coli B088 (18-339/406)
LPIYA
P
A
EFI
PVK
G
Q
G
SR
I
W
D
Q
Q
G
KE
YVD
FAG
GI
AVTAL
GH
C
HP
A
L
V
N
A
L
-
K
T
Q
GETLW
H
IS-NVFTN
E
PA
L
R
L
G
R
K
L
---I
E
ATFAER
V
VFMN
SG
T
EA
N
E
T
A
F
KLAR
HYACVRHSP
FK
TKI
I
A
F
H
N
A
F
HG
R
S
--------
LF
T
V
S
V
GGQ-PK
-
YSDGF
G
PK
P
A
D
IIHVPF-NDLHAVKA-------------
-
VMDDHT
C
A
VV
V
EP
I
-
QG
E
GG
VTAAT
PE
F
L
QG
LR
E
LCD
Q
H
QA
LL
V
F
DEV
QC
G
MG
RTG
D
LFA
YMHYGVT
PD
I
L
T
S
AK
A
L
G
GG
-
F
P
I
S
A
ML
T
T
AE
IA
S
A
FH
PG
S
--
---H
G
S
T
YG
GNPLA
C
A
V
A
G
A
A
F
DIINTPEVL
E
GIQAKRQ
R
F
V
D
H
L
QK
I
D
Q
QYDVFS
D
I
RG
M
G
fig|511693.5.peg.3371
Escherichia coli BL21 (18-339/406)
LPIYA
P
A
EFI
PVK
G
Q
G
SR
I
W
D
Q
Q
G
KE
YVD
FAG
GI
AVTAL
GH
C
HP
A
L
V
N
A
L
-
K
T
Q
GETLW
H
IS-NVFTN
E
PA
L
R
L
G
R
K
L
---I
E
ATFAER
V
VFMN
SG
T
EA
N
E
T
A
F
KLAR
HYACVRHSP
FK
TKI
I
A
F
H
N
A
F
HG
R
S
--------
LF
T
V
S
V
GGQ-PK
-
YSDGF
G
PK
P
A
D
IIHVPF-NDLHAVKA-------------
-
VMDDHT
C
A
VV
V
EP
I
-
QG
E
GG
VTAAT
PE
F
L
QG
LR
E
LCD
Q
H
QA
LL
V
F
DEV
QC
G
MG
RTG
D
LFA
YMHYGVT
PD
I
L
T
S
AK
A
L
G
GG
-
F
P
I
S
A
ML
T
T
AE
IA
S
A
FH
PG
S
--
---H
G
S
T
YG
GNPLA
C
A
V
A
G
A
A
F
DIINTPEVL
E
GIQAKRQ
R
F
V
D
H
L
QK
I
D
Q
QYDVFS
D
I
RG
M
G
fig|469008.4.peg.406
Escherichia coli BL21(DE3) (18-339/406)
LPIYA
P
A
EFI
PVK
G
Q
G
SR
I
W
D
Q
Q
G
KE
YVD
FAG
GI
AVTAL
GH
C
HP
A
L
V
N
A
L
-
K
T
Q
GETLW
H
IS-NVFTN
E
PA
L
R
L
G
R
K
L
---I
E
ATFAER
V
VFMN
SG
T
EA
N
E
T
A
F
KLAR
HYACVRHSP
FK
TKI
I
A
F
H
N
A
F
HG
R
S
--------
LF
T
V
S
V
GGQ-PK
-
YSDGF
G
PK
P
A
D
IIHVPF-NDLHAVKA-------------
-
VMDDHT
C
A
VV
V
EP
I
-
QG
E
GG
VTAAT
PE
F
L
QG
LR
E
LCD
Q
H
QA
LL
V
F
DEV
QC
G
MG
RTG
D
LFA
YMHYGVT
PD
I
L
T
S
AK
A
L
G
GG
-
F
P
I
S
A
ML
T
T
AE
IA
S
A
FH
PG
S
--
---H
G
S
T
YG
GNPLA
C
A
V
A
G
A
A
F
DIINTPEVL
E
GIQAKRQ
R
F
V
D
H
L
QK
I
D
Q
QYDVFS
D
I
RG
M
G
fig|595496.3.peg.3335
Escherichia coli BW2952 (18-339/406)
LPIYA
P
A
EFI
PVK
G
Q
G
SR
I
W
D
Q
Q
G
KE
YVD
FAG
GI
AVTAL
GH
C
HP
A
L
V
N
A
L
-
K
T
Q
GETLW
H
IS-NVFTN
E
PA
L
R
L
G
R
K
L
---I
E
ATFAER
V
VFMN
SG
T
EA
N
E
T
A
F
KLAR
HYACVRHSP
FK
TKI
I
A
F
H
N
A
F
HG
R
S
--------
LF
T
V
S
V
GGQ-PK
-
YSDGF
G
PK
P
A
D
IIHVPF-NDLHAVKA-------------
-
VMDDHT
C
A
VV
V
EP
I
-
QG
E
GG
VTAAT
PE
F
L
QG
LR
E
LCD
Q
H
QA
LL
V
F
DEV
QC
G
MG
RTG
D
LFA
YMHYGVT
PD
I
L
T
S
AK
A
L
G
GG
-
F
P
I
S
A
ML
T
T
AE
IA
S
A
FH
PG
S
--
---H
G
S
T
YG
GNPLA
C
A
V
A
G
A
A
F
DIINTPEVL
E
GIQAKRQ
R
F
V
D
H
L
QK
I
D
Q
QYDVFS
D
I
RG
M
G
fig|536056.3.peg.372
Escherichia coli DH1 (18-339/406)
LPIYA
P
A
EFI
PVK
G
Q
G
SR
I
W
D
Q
Q
G
KE
YVD
FAG
GI
AVTAL
GH
C
HP
A
L
V
N
A
L
-
K
T
Q
GETLW
H
IS-NVFTN
E
PA
L
R
L
G
R
K
L
---I
E
ATFAER
V
VFMN
SG
T
EA
N
E
T
A
F
KLAR
HYACVRHSP
FK
TKI
I
A
F
H
N
A
F
HG
R
S
--------
LF
T
V
S
V
GGQ-PK
-
YSDGF
G
PK
P
A
D
IIHVPF-NDLHAVKA-------------
-
VMDDHT
C
A
VV
V
EP
I
-
QG
E
GG
VTAAT
PE
F
L
QG
LR
E
LCD
Q
H
QA
LL
V
F
DEV
QC
G
MG
RTG
D
LFA
YMHYGVT
PD
I
L
T
S
AK
A
L
G
GG
-
F
P
I
S
A
ML
T
T
AE
IA
S
A
FH
PG
S
--
---H
G
S
T
YG
GNPLA
C
A
V
A
G
A
A
F
DIINTPEVL
E
GIQAKRQ
R
F
V
D
H
L
QK
I
D
Q
QYDVFS
D
I
RG
M
G
fig|331111.12.peg.4076
Escherichia coli E24377A (18-339/406)
LPIYA
P
A
EFI
PVK
G
Q
G
SR
I
W
D
Q
Q
G
KE
YVD
FAG
GI
AVTAL
GH
C
HP
A
L
V
N
A
L
-
K
T
Q
GETLW
H
IS-NVFTN
E
PA
L
R
L
G
R
K
L
---I
E
ATFAER
V
VFMN
SG
T
EA
N
E
T
A
F
KLAR
HYACVRHSP
FK
TKI
I
A
F
H
N
A
F
HG
R
S
--------
LF
T
V
S
V
GGQ-PK
-
YSDGF
G
PK
P
A
D
IIHVPF-NDLHAVKA-------------
-
VMDDHT
C
A
VV
V
EP
I
-
QG
E
GG
VTAAT
PE
F
L
QG
LR
E
LCD
Q
H
QA
LL
V
F
DEV
QC
G
MG
RTG
D
LFA
YMHYGVT
PD
I
L
T
S
AK
A
L
G
GG
-
F
P
I
S
A
ML
T
T
AE
IA
S
A
FH
PG
S
--
---H
G
S
T
YG
GNPLA
C
A
V
A
G
A
A
F
DIINTPEVL
E
GIQAKRQ
R
F
V
D
H
L
QK
I
D
Q
QYDVFS
D
I
RG
M
G
fig|331111.3.peg.1491
Escherichia coli E24377A (18-339/406)
LPIYA
P
A
EFI
PVK
G
Q
G
SR
I
W
D
Q
Q
G
KE
YVD
FAG
GI
AVTAL
GH
C
HP
A
L
V
N
A
L
-
K
T
Q
GETLW
H
IS-NVFTN
E
PA
L
R
L
G
R
K
L
---I
E
ATFAER
V
VFMN
SG
T
EA
N
E
T
A
F
KLAR
HYACVRHSP
FK
TKI
I
A
F
H
N
A
F
HG
R
S
--------
LF
T
V
S
V
GGQ-PK
-
YSDGF
G
PK
P
A
D
IIHVPF-NDLHAVKA-------------
-
VMDDHT
C
A
VV
V
EP
I
-
QG
E
GG
VTAAT
PE
F
L
QG
LR
E
LCD
Q
H
QA
LL
V
F
DEV
QC
G
MG
RTG
D
LFA
YMHYGVT
PD
I
L
T
S
AK
A
L
G
GG
-
F
P
I
S
A
ML
T
T
AE
IA
S
A
FH
PG
S
--
---H
G
S
T
YG
GNPLA
C
A
V
A
G
A
A
F
DIINTPEVL
E
GIQAKRQ
R
F
V
D
H
L
QK
I
D
Q
QYDVFS
D
I
RG
M
G
fig|562.375.peg.4690
Escherichia coli EC4100B (18-339/406)
LPIYA
P
A
EFI
PVK
G
Q
G
SR
I
W
D
Q
Q
G
KE
YVD
FAG
GI
AVTAL
GH
C
HP
A
L
V
N
A
L
-
K
T
Q
GETLW
H
IS-NVFTN
E
PA
L
R
L
G
R
K
L
---I
E
ATFAER
V
VFMN
SG
T
EA
N
E
T
A
F
KLAR
HYACVRHSP
FK
TKI
I
A
F
H
N
A
F
HG
R
S
--------
LF
T
V
S
V
GGQ-PK
-
YSDGF
G
PK
P
A
D
IIHVPF-NDLHAVKA-------------
-
VMDDHT
C
A
VV
V
EP
I
-
QG
E
GG
VTAAT
PE
F
L
QG
LR
E
LCD
Q
H
QA
LL
V
F
DEV
QC
G
MG
RTG
D
LFA
YMHYGVT
PD
I
L
T
S
AK
A
L
G
GG
-
F
P
I
S
A
ML
T
T
AE
IA
S
A
FH
PG
S
--
---H
G
S
T
YG
GNPLA
C
A
V
A
G
A
A
F
DIINTPEVL
E
GIQAKRQ
R
F
V
D
H
L
QK
I
D
Q
QYDVFS
D
I
RG
M
G
fig|316401.4.peg.4091
Escherichia coli ETEC H10407 (18-339/406)
LPIYA
P
A
EFI
PVK
G
Q
G
SR
I
W
D
Q
Q
G
KE
YVD
FAG
GI
AVTAL
GH
C
HP
A
L
V
N
A
L
-
K
T
Q
GETLW
H
IS-NVFTN
E
PA
L
R
L
G
R
K
L
---I
E
ATFAER
V
VFMN
SG
T
EA
N
E
T
A
F
KLAR
HYACVRHSP
FK
TKI
I
A
F
H
N
A
F
HG
R
S
--------
LF
T
V
S
V
GGQ-PK
-
YSDGF
G
PK
P
A
D
IIHVPF-NDLHAVKA-------------
-
VMDDHT
C
A
VV
V
EP
I
-
QG
E
GG
VTAAT
PE
F
L
QG
LR
E
LCD
Q
H
QA
LL
V
F
DEV
QC
G
MG
RTG
D
LFA
YMHYGVT
PD
I
L
T
S
AK
A
L
G
GG
-
F
P
I
S
A
ML
T
T
AE
IA
S
A
FH
PG
S
--
---H
G
S
T
YG
GNPLA
C
A
V
A
G
A
A
F
DIINTPEVL
E
GIQAKRQ
R
F
V
D
H
L
QK
I
D
Q
QYDVFS
D
I
RG
M
G
fig|656393.3.peg.4409
Escherichia coli H299 (18-339/406)
LPIYA
P
A
EFI
PVK
G
Q
G
SR
I
W
D
Q
Q
G
KE
YVD
FAG
GI
AVTAL
GH
C
HP
A
L
V
N
A
L
-
K
T
Q
GETLW
H
IS-NVFTN
E
PA
L
R
L
G
R
K
L
---I
E
ATFAER
V
VFMN
SG
T
EA
N
E
T
A
F
KLAR
HYACVRHSP
FK
TKI
I
A
F
H
N
A
F
HG
R
S
--------
LF
T
V
S
V
GGQ-PK
-
YSDGF
G
PK
P
A
D
IIHVPF-NDLHAVKA-------------
-
VMDDHT
C
A
VV
V
EP
I
-
QG
E
GG
VTAAT
PE
F
L
QG
LR
E
LCD
Q
H
QA
LL
V
F
DEV
QC
G
MG
RTG
D
LFA
YMHYGVT
PD
I
L
T
S
AK
A
L
G
GG
-
F
P
I
S
A
ML
T
T
AE
IA
S
A
FH
PG
S
--
---H
G
S
T
YG
GNPLA
C
A
V
A
G
A
A
F
DIINTPEVL
E
GIQAKRQ
R
F
V
D
H
L
QK
I
D
Q
QYDVFS
D
I
RG
M
G
fig|656408.3.peg.3769
Escherichia coli H591 (18-339/406)
LPIYA
P
A
EFI
PVK
G
Q
G
SR
I
W
D
Q
Q
G
KE
YVD
FAG
GI
AVTAL
GH
C
HP
A
L
V
N
A
L
-
K
T
Q
GETLW
H
IS-NVFTN
E
PA
L
R
L
G
R
K
L
---I
E
ATFAER
V
VFMN
SG
T
EA
N
E
T
A
F
KLAR
HYACVRHSP
FK
TKI
I
A
F
H
N
A
F
HG
R
S
--------
LF
T
V
S
V
GGQ-PK
-
YSDGF
G
PK
P
A
D
IIHVPF-NDLHAVKA-------------
-
VMDDHT
C
A
VV
V
EP
I
-
QG
E
GG
VTAAT
PE
F
L
QG
LR
E
LCD
Q
H
QA
LL
V
F
DEV
QC
G
MG
RTG
D
LFA
YMHYGVT
PD
I
L
T
S
AK
A
L
G
GG
-
F
P
I
S
A
ML
T
T
AE
IA
S
A
FH
PG
S
--
---H
G
S
T
YG
GNPLA
C
A
V
A
G
A
A
F
DIINTPEVL
E
GIQAKRQ
R
F
V
D
H
L
QK
I
D
Q
QYDVFS
D
I
RG
M
G
fig|585034.4.peg.3419
Escherichia coli IAI1 (18-339/406)
LPIYA
P
A
EFI
PVK
G
Q
G
SR
I
W
D
Q
Q
G
KE
YVD
FAG
GI
AVTAL
GH
C
HP
A
L
V
N
A
L
-
K
T
Q
GETLW
H
IS-NVFTN
E
PA
L
R
L
G
R
K
L
---I
E
ATFAER
V
VFMN
SG
T
EA
N
E
T
A
F
KLAR
HYACVRHSP
FK
TKI
I
A
F
H
N
A
F
HG
R
S
--------
LF
T
V
S
V
GGQ-PK
-
YSDGF
G
PK
P
A
D
IIHVPF-NDLHAVKA-------------
-
VMDDHT
C
A
VV
V
EP
I
-
QG
E
GG
VTAAT
PE
F
L
QG
LR
E
LCD
Q
H
QA
LL
V
F
DEV
QC
G
MG
RTG
D
LFA
YMHYGVT
PD
I
L
T
S
AK
A
L
G
GG
-
F
P
I
S
A
ML
T
T
AE
IA
S
A
FH
PG
S
--
---H
G
S
T
YG
GNPLA
C
A
V
A
G
A
A
F
DIINTPEVL
E
GIQAKRQ
R
F
V
D
H
L
QK
I
D
Q
QYDVFS
D
I
RG
M
G
fig|585034.5.peg.3417
Escherichia coli IAI1 (18-339/406)
LPIYA
P
A
EFI
PVK
G
Q
G
SR
I
W
D
Q
Q
G
KE
YVD
FAG
GI
AVTAL
GH
C
HP
A
L
V
N
A
L
-
K
T
Q
GETLW
H
IS-NVFTN
E
PA
L
R
L
G
R
K
L
---I
E
ATFAER
V
VFMN
SG
T
EA
N
E
T
A
F
KLAR
HYACVRHSP
FK
TKI
I
A
F
H
N
A
F
HG
R
S
--------
LF
T
V
S
V
GGQ-PK
-
YSDGF
G
PK
P
A
D
IIHVPF-NDLHAVKA-------------
-
VMDDHT
C
A
VV
V
EP
I
-
QG
E
GG
VTAAT
PE
F
L
QG
LR
E
LCD
Q
H
QA
LL
V
F
DEV
QC
G
MG
RTG
D
LFA
YMHYGVT
PD
I
L
T
S
AK
A
L
G
GG
-
F
P
I
S
A
ML
T
T
AE
IA
S
A
FH
PG
S
--
---H
G
S
T
YG
GNPLA
C
A
V
A
G
A
A
F
DIINTPEVL
E
GIQAKRQ
R
F
V
D
H
L
QK
I
D
Q
QYDVFS
D
I
RG
M
G
fig|585057.4.peg.3970
Escherichia coli IAI39 (18-339/407)
LPIYA
P
A
EFI
PVK
G
Q
G
SR
I
W
D
Q
Q
G
KE
YVD
FAG
GI
AVTAL
GH
C
HP
A
L
V
N
A
L
-
K
T
Q
GETLW
H
IS-NVFTN
E
PA
L
R
L
G
R
K
L
---I
E
ATFAER
V
VFMN
SG
T
EA
N
E
T
A
F
KLAR
HYACVRHSP
FK
TKI
I
A
F
H
N
A
F
HG
R
S
--------
LF
T
V
S
V
GGQ-PK
-
YSDGF
G
PK
P
A
D
IIHVPF-NDLHAVKA-------------
-
VMDDHT
C
A
VV
V
EP
I
-
QG
E
GG
VTAAT
PE
F
L
QG
LR
E
LCD
Q
H
QA
LL
V
F
DEV
QC
G
MG
RTG
D
LFA
YMHYGVT
PD
I
L
T
S
AK
A
L
G
GG
-
F
P
I
S
A
ML
T
T
AE
IA
S
A
FH
PG
S
--
---H
G
S
T
YG
GNPLA
C
A
V
A
G
A
A
F
DIINTPEVL
E
GIQAKRQ
R
F
V
D
H
L
QK
I
D
Q
QYDVFS
D
I
RG
M
G
fig|585057.6.peg.3978
Escherichia coli IAI39 (18-339/407)
LPIYA
P
A
EFI
PVK
G
Q
G
SR
I
W
D
Q
Q
G
KE
YVD
FAG
GI
AVTAL
GH
C
HP
A
L
V
N
A
L
-
K
T
Q
GETLW
H
IS-NVFTN
E
PA
L
R
L
G
R
K
L
---I
E
ATFAER
V
VFMN
SG
T
EA
N
E
T
A
F
KLAR
HYACVRHSP
FK
TKI
I
A
F
H
N
A
F
HG
R
S
--------
LF
T
V
S
V
GGQ-PK
-
YSDGF
G
PK
P
A
D
IIHVPF-NDLHAVKA-------------
-
VMDDHT
C
A
VV
V
EP
I
-
QG
E
GG
VTAAT
PE
F
L
QG
LR
E
LCD
Q
H
QA
LL
V
F
DEV
QC
G
MG
RTG
D
LFA
YMHYGVT
PD
I
L
T
S
AK
A
L
G
GG
-
F
P
I
S
A
ML
T
T
AE
IA
S
A
FH
PG
S
--
---H
G
S
T
YG
GNPLA
C
A
V
A
G
A
A
F
DIINTPEVL
E
GIQAKRQ
R
F
V
D
H
L
QK
I
D
Q
QYDVFS
D
I
RG
M
G
fig|83333.1.peg.3294
Escherichia coli K12 (18-339/406)
LPIYA
P
A
EFI
PVK
G
Q
G
SR
I
W
D
Q
Q
G
KE
YVD
FAG
GI
AVTAL
GH
C
HP
A
L
V
N
A
L
-
K
T
Q
GETLW
H
IS-NVFTN
E
PA
L
R
L
G
R
K
L
---I
E
ATFAER
V
VFMN
SG
T
EA
N
E
T
A
F
KLAR
HYACVRHSP
FK
TKI
I
A
F
H
N
A
F
HG
R
S
--------
LF
T
V
S
V
GGQ-PK
-
YSDGF
G
PK
P
A
D
IIHVPF-NDLHAVKA-------------
-
VMDDHT
C
A
VV
V
EP
I
-
QG
E
GG
VTAAT
PE
F
L
QG
LR
E
LCD
Q
H
QA
LL
V
F
DEV
QC
G
MG
RTG
D
LFA
YMHYGVT
PD
I
L
T
S
AK
A
L
G
GG
-
F
P
I
S
A
ML
T
T
AE
IA
S
A
FH
PG
S
--
---H
G
S
T
YG
GNPLA
C
A
V
A
G
A
A
F
DIINTPEVL
E
GIQAKRQ
R
F
V
D
H
L
QK
I
D
Q
QYDVFS
D
I
RG
M
G
fig|749538.3.peg.504
Escherichia coli MS 116-1 (18-339/406)
LPIYA
P
A
EFI
PVK
G
Q
G
SR
I
W
D
Q
Q
G
KE
YVD
FAG
GI
AVTAL
GH
C
HP
A
L
V
N
A
L
-
K
T
Q
GETLW
H
IS-NVFTN
E
PA
L
R
L
G
R
K
L
---I
E
ATFAER
V
VFMN
SG
T
EA
N
E
T
A
F
KLAR
HYACVRHSP
FK
TKI
I
A
F
H
N
A
F
HG
R
S
--------
LF
T
V
S
V
GGQ-PK
-
YSDGF
G
PK
P
A
D
IIHVPF-NDLHAVKA-------------
-
VMDDHT
C
A
VV
V
EP
I
-
QG
E
GG
VTAAT
PE
F
L
QG
LR
E
LCD
Q
H
QA
LL
V
F
DEV
QC
G
MG
RTG
D
LFA
YMHYGVT
PD
I
L
T
S
AK
A
L
G
GG
-
F
P
I
S
A
ML
T
T
AE
IA
S
A
FH
PG
S
--
---H
G
S
T
YG
GNPLA
C
A
V
A
G
A
A
F
DIINTPEVL
E
GIQAKRQ
R
F
V
D
H
L
QK
I
D
Q
QYDVFS
D
I
RG
M
G
fig|679206.4.peg.2622
Escherichia coli MS 119-7 (18-339/406)
LPIYA
P
A
EFI
PVK
G
Q
G
SR
I
W
D
Q
Q
G
KE
YVD
FAG
GI
AVTAL
GH
C
HP
A
L
V
N
A
L
-
K
T
Q
GETLW
H
IS-NVFTN
E
PA
L
R
L
G
R
K
L
---I
E
ATFAER
V
VFMN
SG
T
EA
N
E
T
A
F
KLAR
HYACVRHSP
FK
TKI
I
A
F
H
N
A
F
HG
R
S
--------
LF
T
V
S
V
GGQ-PK
-
YSDGF
G
PK
P
A
D
IIHVPF-NDLHAVKA-------------
-
VMDDHT
C
A
VV
V
EP
I
-
QG
E
GG
VTAAT
PE
F
L
QG
LR
E
LCD
Q
H
QA
LL
V
F
DEV
QC
G
MG
RTG
D
LFA
YMHYGVT
PD
I
L
T
S
AK
A
L
G
GG
-
F
P
I
S
A
ML
T
T
AE
IA
S
A
FH
PG
S
--
---H
G
S
T
YG
GNPLA
C
A
V
A
G
A
A
F
DIINTPEVL
E
GIQAKRQ
R
F
V
D
H
L
QK
I
D
Q
QYDVFS
D
I
RG
M
G
fig|679205.4.peg.760
Escherichia coli MS 124-1 (18-339/406)
LPIYA
P
A
EFI
PVK
G
Q
G
SR
I
W
D
Q
Q
G
KE
YVD
FAG
GI
AVTAL
GH
C
HP
A
L
V
N
A
L
-
K
T
Q
GETLW
H
IS-NVFTN
E
PA
L
R
L
G
R
K
L
---I
E
ATFAER
V
VFMN
SG
T
EA
N
E
T
A
F
KLAR
HYACVRHSP
FK
TKI
I
A
F
H
N
A
F
HG
R
S
--------
LF
T
V
S
V
GGQ-PK
-
YSDGF
G
PK
P
A
D
IIHVPF-NDLHAVKA-------------
-
VMDDHT
C
A
VV
V
EP
I
-
QG
E
GG
VTAAT
PE
F
L
QG
LR
E
LCD
Q
H
QA
LL
V
F
DEV
QC
G
MG
RTG
D
LFA
YMHYGVT
PD
I
L
T
S
AK
A
L
G
GG
-
F
P
I
S
A
ML
T
T
AE
IA
S
A
FH
PG
S
--
---H
G
S
T
YG
GNPLA
C
A
V
A
G
A
A
F
DIINTPEVL
E
GIQAKRQ
R
F
V
D
H
L
QK
I
D
Q
QYDVFS
D
I
RG
M
G
fig|749540.3.peg.2294
Escherichia coli MS 146-1 (18-339/406)
LPIYA
P
A
EFI
PVK
G
Q
G
SR
I
W
D
Q
Q
G
KE
YVD
FAG
GI
AVTAL
GH
C
HP
A
L
V
N
A
L
-
K
T
Q
GETLW
H
IS-NVFTN
E
PA
L
R
L
G
R
K
L
---I
E
ATFAER
V
VFMN
SG
T
EA
N
E
T
A
F
KLAR
HYACVRHSP
FK
TKI
I
A
F
H
N
A
F
HG
R
S
--------
LF
T
V
S
V
GGQ-PK
-
YSDGF
G
PK
P
A
D
IIHVPF-NDLHAVKA-------------
-
VMDDHT
C
A
VV
V
EP
I
-
QG
E
GG
VTAAT
PE
F
L
QG
LR
E
LCD
Q
H
QA
LL
V
F
DEV
QC
G
MG
RTG
D
LFA
YMHYGVT
PD
I
L
T
S
AK
A
L
G
GG
-
F
P
I
S
A
ML
T
T
AE
IA
S
A
FH
PG
S
--
---H
G
S
T
YG
GNPLA
C
A
V
A
G
A
A
F
DIINTPEVL
E
GIQAKRQ
R
F
V
D
H
L
QK
I
D
Q
QYDVFS
D
I
RG
M
G
fig|749544.3.peg.2592
Escherichia coli MS 175-1 (18-339/406)
LPIYA
P
A
EFI
PVK
G
Q
G
SR
I
W
D
Q
Q
G
KE
YVD
FAG
GI
AVTAL
GH
C
HP
A
L
V
N
A
L
-
K
T
Q
GETLW
H
IS-NVFTN
E
PA
L
R
L
G
R
K
L
---I
E
ATFAER
V
VFMN
SG
T
EA
N
E
T
A
F
KLAR
HYACVRHSP
FK
TKI
I
A
F
H
N
A
F
HG
R
S
--------
LF
T
V
S
V
GGQ-PK
-
YSDGF
G
PK
P
A
D
IIHVPF-NDLHAVKA-------------
-
VMDDHT
C
A
VV
V
EP
I
-
QG
E
GG
VTAAT
PE
F
L
QG
LR
E
LCD
Q
H
QA
LL
V
F
DEV
QC
G
MG
RTG
D
LFA
YMHYGVT
PD
I
L
T
S
AK
A
L
G
GG
-
F
P
I
S
A
ML
T
T
AE
IA
S
A
FH
PG
S
--
---H
G
S
T
YG
GNPLA
C
A
V
A
G
A
A
F
DIINTPEVL
E
GIQAKRQ
R
F
V
D
H
L
QK
I
D
Q
QYDVFS
D
I
RG
M
G
fig|749547.3.peg.3259
Escherichia coli MS 187-1 (18-339/406)
LPIYA
P
A
EFI
PVK
G
Q
G
SR
I
W
D
Q
Q
G
KE
YVD
FAG
GI
AVTAL
GH
C
HP
A
L
V
N
A
L
-
K
T
Q
GETLW
H
IS-NVFTN
E
PA
L
R
L
G
R
K
L
---I
E
ATFAER
V
VFMN
SG
T
EA
N
E
T
A
F
KLAR
HYACVRHSP
FK
TKI
I
A
F
H
N
A
F
HG
R
S
--------
LF
T
V
S
V
GGQ-PK
-
YSDGF
G
PK
P
A
D
IIHVPF-NDLHAVKA-------------
-
VMDDHT
C
A
VV
V
EP
I
-
QG
E
GG
VTAAT
PE
F
L
QG
LR
E
LCD
Q
H
QA
LL
V
F
DEV
QC
G
MG
RTG
D
LFA
YMHYGVT
PD
I
L
T
S
AK
A
L
G
GG
-
F
P
I
S
A
ML
T
T
AE
IA
S
A
FH
PG
S
--
---H
G
S
T
YG
GNPLA
C
A
V
A
G
A
A
F
DIINTPEVL
E
GIQAKRQ
R
F
V
D
H
L
QK
I
D
Q
QYDVFS
D
I
RG
M
G
fig|749548.3.peg.1675
Escherichia coli MS 196-1 (18-339/406)
LPIYA
P
A
EFI
PVK
G
Q
G
SR
I
W
D
Q
Q
G
KE
YVD
FAG
GI
AVTAL
GH
C
HP
A
L
V
N
A
L
-
K
T
Q
GETLW
H
IS-NVFTN
E
PA
L
R
L
G
R
K
L
---I
E
ATFAER
V
VFMN
SG
T
EA
N
E
T
A
F
KLAR
HYACVRHSP
FK
TKI
I
A
F
H
N
A
F
HG
R
S
--------
LF
T
V
S
V
GGQ-PK
-
YSDGF
G
PK
P
A
D
IIHVPF-NDLHAVKA-------------
-
VMDDHT
C
A
VV
V
EP
I
-
QG
E
GG
VTAAT
PE
F
L
QG
LR
E
LCD
Q
H
QA
LL
V
F
DEV
QC
G
MG
RTG
D
LFA
YMHYGVT
PD
I
L
T
S
AK
A
L
G
GG
-
F
P
I
S
A
ML
T
T
AE
IA
S
A
FH
PG
S
--
---H
G
S
T
YG
GNPLA
C
A
V
A
G
A
A
F
DIINTPEVL
E
GIQAKRQ
R
F
V
D
H
L
QK
I
D
Q
QYDVFS
D
I
RG
M
G
fig|749527.3.peg.268
Escherichia coli MS 21-1 (18-339/407)
LPIYA
P
A
EFI
PVK
G
Q
G
SR
I
W
D
Q
Q
G
KE
YVD
FAG
GI
AVTAL
GH
C
HP
A
L
V
N
A
L
-
K
T
Q
GETLW
H
IS-NVFTN
E
PA
L
R
L
G
R
K
L
---I
E
ATFAER
V
VFMN
SG
T
EA
N
E
T
A
F
KLAR
HYACVRHSP
FK
TKI
I
A
F
H
N
A
F
HG
R
S
--------
LF
T
V
S
V
GGQ-PK
-
YSDGF
G
PK
P
A
D
IIHVPF-NDLHAVKA-------------
-
VMDDHT
C
A
VV
V
EP
I
-
QG
E
GG
VTAAT
PE
F
L
QG
LR
E
LCD
Q
H
QA
LL
V
F
DEV
QC
G
MG
RTG
D
LFA
YMHYGVT
PD
I
L
T
S
AK
A
L
G
GG
-
F
P
I
S
A
ML
T
T
AE
IA
S
A
FH
PG
S
--
---H
G
S
T
YG
GNPLA
C
A
V
A
G
A
A
F
DIINTPEVL
E
GIQAKRQ
R
F
V
D
H
L
QK
I
D
Q
QYDVFS
D
I
RG
M
G
fig|749533.3.peg.4975
Escherichia coli MS 84-1 (18-339/406)
LPIYA
P
A
EFI
PVK
G
Q
G
SR
I
W
D
Q
Q
G
KE
YVD
FAG
GI
AVTAL
GH
C
HP
A
L
V
N
A
L
-
K
T
Q
GETLW
H
IS-NVFTN
E
PA
L
R
L
G
R
K
L
---I
E
ATFAER
V
VFMN
SG
T
EA
N
E
T
A
F
KLAR
HYACVRHSP
FK
TKI
I
A
F
H
N
A
F
HG
R
S
--------
LF
T
V
S
V
GGQ-PK
-
YSDGF
G
PK
P
A
D
IIHVPF-NDLHAVKA-------------
-
VMDDHT
C
A
VV
V
EP
I
-
QG
E
GG
VTAAT
PE
F
L
QG
LR
E
LCD
Q
H
QA
LL
V
F
DEV
QC
G
MG
RTG
D
LFA
YMHYGVT
PD
I
L
T
S
AK
A
L
G
GG
-
F
P
I
S
A
ML
T
T
AE
IA
S
A
FH
PG
S
--
---H
G
S
T
YG
GNPLA
C
A
V
A
G
A
A
F
DIINTPEVL
E
GIQAKRQ
R
F
V
D
H
L
QK
I
D
Q
QYDVFS
D
I
RG
M
G
fig|585396.4.peg.4311
Escherichia coli O111:H- str. 11128 (18-339/406)
LPIYA
P
A
EFI
PVK
G
Q
G
SR
I
W
D
Q
Q
G
KE
YVD
FAG
GI
AVTAL
GH
C
HP
A
L
V
N
A
L
-
K
T
Q
GETLW
H
IS-NVFTN
E
PA
L
R
L
G
R
K
L
---I
E
ATFAER
V
VFMN
SG
T
EA
N
E
T
A
F
KLAR
HYACVRHSP
FK
TKI
I
A
F
H
N
A
F
HG
R
S
--------
LF
T
V
S
V
GGQ-PK
-
YSDGF
G
PK
P
A
D
IIHVPF-NDLHAVKA-------------
-
VMDDHT
C
A
VV
V
EP
I
-
QG
E
GG
VTAAT
PE
F
L
QG
LR
E
LCD
Q
H
QA
LL
V
F
DEV
QC
G
MG
RTG
D
LFA
YMHYGVT
PD
I
L
T
S
AK
A
L
G
GG
-
F
P
I
S
A
ML
T
T
AE
IA
S
A
FH
PG
S
--
---H
G
S
T
YG
GNPLA
C
A
V
A
G
A
A
F
DIINTPEVL
E
GIQAKRQ
R
F
V
D
H
L
QK
I
D
Q
QYDVFS
D
I
RG
M
G
fig|573235.3.peg.4554
Escherichia coli O26:H11 str. 11368 (18-339/406)
LPIYA
P
A
EFI
PVK
G
Q
G
SR
I
W
D
Q
Q
G
KE
YVD
FAG
GI
AVTAL
GH
C
HP
A
L
V
N
A
L
-
K
T
Q
GETLW
H
IS-NVFTN
E
PA
L
R
L
G
R
K
L
---I
E
ATFAER
V
VFMN
SG
T
EA
N
E
T
A
F
KLAR
HYACVRHSP
FK
TKI
I
A
F
H
N
A
F
HG
R
S
--------
LF
T
V
S
V
GGQ-PK
-
YSDGF
G
PK
P
A
D
IIHVPF-NDLHAVKA-------------
-
VMDDHT
C
A
VV
V
EP
I
-
QG
E
GG
VTAAT
PE
F
L
QG
LR
E
LCD
Q
H
QA
LL
V
F
DEV
QC
G
MG
RTG
D
LFA
YMHYGVT
PD
I
L
T
S
AK
A
L
G
GG
-
F
P
I
S
A
ML
T
T
AE
IA
S
A
FH
PG
S
--
---H
G
S
T
YG
GNPLA
C
A
V
A
G
A
A
F
DIINTPEVL
E
GIQAKRQ
R
F
V
D
H
L
QK
I
D
Q
QYDVFS
D
I
RG
M
G
fig|409438.11.peg.3788
Escherichia coli SE11 (18-339/406)
LPIYA
P
A
EFI
PVK
G
Q
G
SR
I
W
D
Q
Q
G
KE
YVD
FAG
GI
AVTAL
GH
C
HP
A
L
V
N
A
L
-
K
T
Q
GETLW
H
IS-NVFTN
E
PA
L
R
L
G
R
K
L
---I
E
ATFAER
V
VFMN
SG
T
EA
N
E
T
A
F
KLAR
HYACVRHSP
FK
TKI
I
A
F
H
N
A
F
HG
R
S
--------
LF
T
V
S
V
GGQ-PK
-
YSDGF
G
PK
P
A
D
IIHVPF-NDLHAVKA-------------
-
VMDDHT
C
A
VV
V
EP
I
-
QG
E
GG
VTAAT
PE
F
L
QG
LR
E
LCD
Q
H
QA
LL
V
F
DEV
QC
G
MG
RTG
D
LFA
YMHYGVT
PD
I
L
T
S
AK
A
L
G
GG
-
F
P
I
S
A
ML
T
T
AE
IA
S
A
FH
PG
S
--
---H
G
S
T
YG
GNPLA
C
A
V
A
G
A
A
F
DIINTPEVL
E
GIQAKRQ
R
F
V
D
H
L
QK
I
D
Q
QYDVFS
D
I
RG
M
G
fig|431946.3.peg.3320
Escherichia coli SE15 (18-339/406)
LPIYA
P
A
EFI
PVK
G
Q
G
SR
I
W
D
Q
Q
G
KE
YVD
FAG
GI
AVTAL
GH
C
HP
A
L
V
N
A
L
-
K
T
Q
GETLW
H
IS-NVFTN
E
PA
L
R
L
G
R
K
L
---I
E
ATFAER
V
VFMN
SG
T
EA
N
E
T
A
F
KLAR
HYACVRHSP
FK
TKI
I
A
F
H
N
A
F
HG
R
S
--------
LF
T
V
S
V
GGQ-PK
-
YSDGF
G
PK
P
A
D
IIHVPF-NDLHAVKA-------------
-
VMDDHT
C
A
VV
V
EP
I
-
QG
E
GG
VTAAT
PE
F
L
QG
LR
E
LCD
Q
H
QA
LL
V
F
DEV
QC
G
MG
RTG
D
LFA
YMHYGVT
PD
I
L
T
S
AK
A
L
G
GG
-
F
P
I
S
A
ML
T
T
AE
IA
S
A
FH
PG
S
--
---H
G
S
T
YG
GNPLA
C
A
V
A
G
A
A
F
DIINTPEVL
E
GIQAKRQ
R
F
V
D
H
L
QK
I
D
Q
QYDVFS
D
I
RG
M
G
fig|439855.10.peg.3790
Escherichia coli SMS-3-5 (18-339/407)
LPIYA
P
A
EFI
PVK
G
Q
G
SR
I
W
D
Q
Q
G
KE
YVD
FAG
GI
AVTAL
GH
C
HP
A
L
V
N
A
L
-
K
T
Q
GETLW
H
IS-NVFTN
E
PA
L
R
L
G
R
K
L
---I
E
ATFAER
V
VFMN
SG
T
EA
N
E
T
A
F
KLAR
HYACVRHSP
FK
TKI
I
A
F
H
N
A
F
HG
R
S
--------
LF
T
V
S
V
GGQ-PK
-
YSDGF
G
PK
P
A
D
IIHVPF-NDLHAVKA-------------
-
VMDDHT
C
A
VV
V
EP
I
-
QG
E
GG
VTAAT
PE
F
L
QG
LR
E
LCD
Q
H
QA
LL
V
F
DEV
QC
G
MG
RTG
D
LFA
YMHYGVT
PD
I
L
T
S
AK
A
L
G
GG
-
F
P
I
S
A
ML
T
T
AE
IA
S
A
FH
PG
S
--
---H
G
S
T
YG
GNPLA
C
A
V
A
G
A
A
F
DIINTPEVL
E
GIQAKRQ
R
F
V
D
H
L
QK
I
D
Q
QYDVFS
D
I
RG
M
G
fig|656443.3.peg.4247
Escherichia coli TA271 (18-339/406)
LPIYA
P
A
EFI
PVK
G
Q
G
SR
I
W
D
Q
Q
G
KE
YVD
FAG
GI
AVTAL
GH
C
HP
A
L
V
N
A
L
-
K
T
Q
GETLW
H
IS-NVFTN
E
PA
L
R
L
G
R
K
L
---I
E
ATFAER
V
VFMN
SG
T
EA
N
E
T
A
F
KLAR
HYACVRHSP
FK
TKI
I
A
F
H
N
A
F
HG
R
S
--------
LF
T
V
S
V
GGQ-PK
-
YSDGF
G
PK
P
A
D
IIHVPF-NDLHAVKA-------------
-
VMDDHT
C
A
VV
V
EP
I
-
QG
E
GG
VTAAT
PE
F
L
QG
LR
E
LCD
Q
H
QA
LL
V
F
DEV
QC
G
MG
RTG
D
LFA
YMHYGVT
PD
I
L
T
S
AK
A
L
G
GG
-
F
P
I
S
A
ML
T
T
AE
IA
S
A
FH
PG
S
--
---H
G
S
T
YG
GNPLA
C
A
V
A
G
A
A
F
DIINTPEVL
E
GIQAKRQ
R
F
V
D
H
L
QK
I
D
Q
QYDVFS
D
I
RG
M
G
fig|316407.3.peg.3766
Escherichia coli W3110 (18-339/406)
LPIYA
P
A
EFI
PVK
G
Q
G
SR
I
W
D
Q
Q
G
KE
YVD
FAG
GI
AVTAL
GH
C
HP
A
L
V
N
A
L
-
K
T
Q
GETLW
H
IS-NVFTN
E
PA
L
R
L
G
R
K
L
---I
E
ATFAER
V
VFMN
SG
T
EA
N
E
T
A
F
KLAR
HYACVRHSP
FK
TKI
I
A
F
H
N
A
F
HG
R
S
--------
LF
T
V
S
V
GGQ-PK
-
YSDGF
G
PK
P
A
D
IIHVPF-NDLHAVKA-------------
-
VMDDHT
C
A
VV
V
EP
I
-
QG
E
GG
VTAAT
PE
F
L
QG
LR
E
LCD
Q
H
QA
LL
V
F
DEV
QC
G
MG
RTG
D
LFA
YMHYGVT
PD
I
L
T
S
AK
A
L
G
GG
-
F
P
I
S
A
ML
T
T
AE
IA
S
A
FH
PG
S
--
---H
G
S
T
YG
GNPLA
C
A
V
A
G
A
A
F
DIINTPEVL
E
GIQAKRQ
R
F
V
D
H
L
QK
I
D
Q
QYDVFS
D
I
RG
M
G
fig|316385.5.peg.3481
Escherichia coli str. K-12 substr. DH10B (18-339/406)
LPIYA
P
A
EFI
PVK
G
Q
G
SR
I
W
D
Q
Q
G
KE
YVD
FAG
GI
AVTAL
GH
C
HP
A
L
V
N
A
L
-
K
T
Q
GETLW
H
IS-NVFTN
E
PA
L
R
L
G
R
K
L
---I
E
ATFAER
V
VFMN
SG
T
EA
N
E
T
A
F
KLAR
HYACVRHSP
FK
TKI
I
A
F
H
N
A
F
HG
R
S
--------
LF
T
V
S
V
GGQ-PK
-
YSDGF
G
PK
P
A
D
IIHVPF-NDLHAVKA-------------
-
VMDDHT
C
A
VV
V
EP
I
-
QG
E
GG
VTAAT
PE
F
L
QG
LR
E
LCD
Q
H
QA
LL
V
F
DEV
QC
G
MG
RTG
D
LFA
YMHYGVT
PD
I
L
T
S
AK
A
L
G
GG
-
F
P
I
S
A
ML
T
T
AE
IA
S
A
FH
PG
S
--
---H
G
S
T
YG
GNPLA
C
A
V
A
G
A
A
F
DIINTPEVL
E
GIQAKRQ
R
F
V
D
H
L
QK
I
D
Q
QYDVFS
D
I
RG
M
G
fig|316385.7.peg.3557
Escherichia coli str. K-12 substr. DH10B (18-339/406)
LPIYA
P
A
EFI
PVK
G
Q
G
SR
I
W
D
Q
Q
G
KE
YVD
FAG
GI
AVTAL
GH
C
HP
A
L
V
N
A
L
-
K
T
Q
GETLW
H
IS-NVFTN
E
PA
L
R
L
G
R
K
L
---I
E
ATFAER
V
VFMN
SG
T
EA
N
E
T
A
F
KLAR
HYACVRHSP
FK
TKI
I
A
F
H
N
A
F
HG
R
S
--------
LF
T
V
S
V
GGQ-PK
-
YSDGF
G
PK
P
A
D
IIHVPF-NDLHAVKA-------------
-
VMDDHT
C
A
VV
V
EP
I
-
QG
E
GG
VTAAT
PE
F
L
QG
LR
E
LCD
Q
H
QA
LL
V
F
DEV
QC
G
MG
RTG
D
LFA
YMHYGVT
PD
I
L
T
S
AK
A
L
G
GG
-
F
P
I
S
A
ML
T
T
AE
IA
S
A
FH
PG
S
--
---H
G
S
T
YG
GNPLA
C
A
V
A
G
A
A
F
DIINTPEVL
E
GIQAKRQ
R
F
V
D
H
L
QK
I
D
Q
QYDVFS
D
I
RG
M
G
fig|511145.12.peg.3453
Escherichia coli str. K-12 substr. MG1655 (18-339/406)
LPIYA
P
A
EFI
PVK
G
Q
G
SR
I
W
D
Q
Q
G
KE
YVD
FAG
GI
AVTAL
GH
C
HP
A
L
V
N
A
L
-
K
T
Q
GETLW
H
IS-NVFTN
E
PA
L
R
L
G
R
K
L
---I
E
ATFAER
V
VFMN
SG
T
EA
N
E
T
A
F
KLAR
HYACVRHSP
FK
TKI
I
A
F
H
N
A
F
HG
R
S
--------
LF
T
V
S
V
GGQ-PK
-
YSDGF
G
PK
P
A
D
IIHVPF-NDLHAVKA-------------
-
VMDDHT
C
A
VV
V
EP
I
-
QG
E
GG
VTAAT
PE
F
L
QG
LR
E
LCD
Q
H
QA
LL
V
F
DEV
QC
G
MG
RTG
D
LFA
YMHYGVT
PD
I
L
T
S
AK
A
L
G
GG
-
F
P
I
S
A
ML
T
T
AE
IA
S
A
FH
PG
S
--
---H
G
S
T
YG
GNPLA
C
A
V
A
G
A
A
F
DIINTPEVL
E
GIQAKRQ
R
F
V
D
H
L
QK
I
D
Q
QYDVFS
D
I
RG
M
G
fig|511145.6.peg.3437
Escherichia coli str. K-12 substr. MG1655 (18-339/406)
LPIYA
P
A
EFI
PVK
G
Q
G
SR
I
W
D
Q
Q
G
KE
YVD
FAG
GI
AVTAL
GH
C
HP
A
L
V
N
A
L
-
K
T
Q
GETLW
H
IS-NVFTN
E
PA
L
R
L
G
R
K
L
---I
E
ATFAER
V
VFMN
SG
T
EA
N
E
T
A
F
KLAR
HYACVRHSP
FK
TKI
I
A
F
H
N
A
F
HG
R
S
--------
LF
T
V
S
V
GGQ-PK
-
YSDGF
G
PK
P
A
D
IIHVPF-NDLHAVKA-------------
-
VMDDHT
C
A
VV
V
EP
I
-
QG
E
GG
VTAAT
PE
F
L
QG
LR
E
LCD
Q
H
QA
LL
V
F
DEV
QC
G
MG
RTG
D
LFA
YMHYGVT
PD
I
L
T
S
AK
A
L
G
GG
-
F
P
I
S
A
ML
T
T
AE
IA
S
A
FH
PG
S
--
---H
G
S
T
YG
GNPLA
C
A
V
A
G
A
A
F
DIINTPEVL
E
GIQAKRQ
R
F
V
D
H
L
QK
I
D
Q
QYDVFS
D
I
RG
M
G
fig|562.376.peg.288
Escherichia coli WV_060327 (18-339/406)
LPIYA
P
A
EFI
PVK
G
Q
G
SR
I
W
D
Q
Q
G
KE
YVD
FAG
GI
AVTAL
GH
C
HP
A
L
V
N
A
L
-
K
T
Q
GKTLW
H
IS-NVFTN
E
PA
L
R
L
G
R
K
L
---I
E
ATFAER
V
VFMN
SG
T
EA
N
E
T
A
F
KLAR
HYACVRHSP
FK
TKI
I
A
F
H
N
A
F
HG
R
S
--------
LF
T
V
S
V
GGQ-PK
-
YSDGF
G
PK
P
A
D
IIHVPF-NDLHAVKA-------------
-
VMDDHT
C
A
VV
V
EP
I
-
QG
E
GG
VTAAT
PE
F
L
QG
LR
E
LCD
Q
H
QA
LL
V
F
DEV
QS
G
MG
RTG
D
LFA
YMHYGVT
PD
I
L
T
S
AK
A
L
G
GG
-
F
P
V
S
A
ML
T
T
AE
IA
S
A
FH
PG
S
--
---H
G
S
T
YG
GNPLA
C
A
V
A
G
A
A
F
DIINTPEVL
E
GIQAKRQ
R
F
V
D
H
L
QK
I
D
Q
QYDVFS
D
I
RG
M
G
fig|405955.13.peg.3778
Escherichia coli APEC O1 (18-339/406)
LPIYA
P
A
EFI
PVK
G
Q
G
SR
I
W
D
Q
Q
G
KE
YVD
FAG
GI
AVTAL
GH
C
HP
A
L
V
N
A
L
-
K
T
Q
GETLW
H
IS-NVFTN
E
PA
L
R
L
G
R
K
L
---I
E
ATFAER
V
VFMN
SG
T
EA
N
E
T
A
F
KLAR
HYACVRHSP
FK
TKI
I
A
F
H
N
A
F
HG
R
S
--------
LF
T
V
S
V
GGQ-PK
-
YSDGF
G
PK
P
A
D
IIHVPF-NDLHAVKA-------------
-
VMDDHT
C
A
VV
V
EP
I
-
QG
E
GG
VTAAT
PE
F
L
QG
LR
E
LCD
Q
H
QA
LL
V
F
DEV
QC
G
MG
RTG
D
LFA
YMHYGVT
PD
I
L
T
S
AK
A
L
G
GG
-
F
P
V
S
A
ML
T
T
AE
IA
S
A
FH
PG
S
--
---H
G
S
T
YG
GNPLA
C
A
V
A
G
A
A
F
DIINTPEVL
E
GIQAKRQ
R
F
V
D
H
L
QK
I
D
Q
QYDVFS
D
I
RG
M
G
fig|405955.9.peg.3160
Escherichia coli APEC O1 (18-339/406)
LPIYA
P
A
EFI
PVK
G
Q
G
SR
I
W
D
Q
Q
G
KE
YVD
FAG
GI
AVTAL
GH
C
HP
A
L
V
N
A
L
-
K
T
Q
GETLW
H
IS-NVFTN
E
PA
L
R
L
G
R
K
L
---I
E
ATFAER
V
VFMN
SG
T
EA
N
E
T
A
F
KLAR
HYACVRHSP
FK
TKI
I
A
F
H
N
A
F
HG
R
S
--------
LF
T
V
S
V
GGQ-PK
-
YSDGF
G
PK
P
A
D
IIHVPF-NDLHAVKA-------------
-
VMDDHT
C
A
VV
V
EP
I
-
QG
E
GG
VTAAT
PE
F
L
QG
LR
E
LCD
Q
H
QA
LL
V
F
DEV
QC
G
MG
RTG
D
LFA
YMHYGVT
PD
I
L
T
S
AK
A
L
G
GG
-
F
P
V
S
A
ML
T
T
AE
IA
S
A
FH
PG
S
--
---H
G
S
T
YG
GNPLA
C
A
V
A
G
A
A
F
DIINTPEVL
E
GIQAKRQ
R
F
V
D
H
L
QK
I
D
Q
QYDVFS
D
I
RG
M
G
fig|714962.3.peg.3811
Escherichia coli IHE3034 (18-339/406)
LPIYA
P
A
EFI
PVK
G
Q
G
SR
I
W
D
Q
Q
G
KE
YVD
FAG
GI
AVTAL
GH
C
HP
A
L
V
N
A
L
-
K
T
Q
GETLW
H
IS-NVFTN
E
PA
L
R
L
G
R
K
L
---I
E
ATFAER
V
VFMN
SG
T
EA
N
E
T
A
F
KLAR
HYACVRHSP
FK
TKI
I
A
F
H
N
A
F
HG
R
S
--------
LF
T
V
S
V
GGQ-PK
-
YSDGF
G
PK
P
A
D
IIHVPF-NDLHAVKA-------------
-
VMDDHT
C
A
VV
V
EP
I
-
QG
E
GG
VTAAT
PE
F
L
QG
LR
E
LCD
Q
H
QA
LL
V
F
DEV
QC
G
MG
RTG
D
LFA
YMHYGVT
PD
I
L
T
S
AK
A
L
G
GG
-
F
P
V
S
A
ML
T
T
AE
IA
S
A
FH
PG
S
--
---H
G
S
T
YG
GNPLA
C
A
V
A
G
A
A
F
DIINTPEVL
E
GIQAKRQ
R
F
V
D
H
L
QK
I
D
Q
QYDVFS
D
I
RG
M
G
fig|585035.6.peg.3675
Escherichia coli S88 (18-339/406)
LPIYA
P
A
EFI
PVK
G
Q
G
SR
I
W
D
Q
Q
G
KE
YVD
FAG
GI
AVTAL
GH
C
HP
A
L
V
N
A
L
-
K
T
Q
GETLW
H
IS-NVFTN
E
PA
L
R
L
G
R
K
L
---I
E
ATFAER
V
VFMN
SG
T
EA
N
E
T
A
F
KLAR
HYACVRHSP
FK
TKI
I
A
F
H
N
A
F
HG
R
S
--------
LF
T
V
S
V
GGQ-PK
-
YSDGF
G
PK
P
A
D
IIHVPF-NDLHAVKA-------------
-
VMDDHT
C
A
VV
V
EP
I
-
QG
E
GG
VTAAT
PE
F
L
QG
LR
E
LCD
Q
H
QA
LL
V
F
DEV
QC
G
MG
RTG
D
LFA
YMHYGVT
PD
I
L
T
S
AK
A
L
G
GG
-
F
P
V
S
A
ML
T
T
AE
IA
S
A
FH
PG
S
--
---H
G
S
T
YG
GNPLA
C
A
V
A
G
A
A
F
DIINTPEVL
E
GIQAKRQ
R
F
V
D
H
L
QK
I
D
Q
QYDVFS
D
I
RG
M
G
fig|656440.3.peg.3598
Escherichia coli TA206 (18-339/406)
LPIYA
P
A
EFI
PVK
G
Q
G
SR
I
W
D
Q
Q
G
KE
YVD
FAG
GI
AVTAL
GH
C
HP
A
L
V
N
A
L
-
K
T
Q
GETLW
H
IS-NVFTN
E
PA
L
R
L
G
R
K
L
---I
E
ATFAER
V
VFMN
SG
T
EA
N
E
T
A
F
KLAR
HYACVRHSP
FK
TKI
I
A
F
H
N
A
F
HG
R
S
--------
LF
T
V
S
V
GGQ-PK
-
YSDGF
G
PK
P
A
D
IIHVPF-NDLHAVKA-------------
-
VMDDHT
C
A
VV
V
EP
I
-
QG
E
GG
VTAAT
PE
F
L
QG
LR
E
LCD
Q
H
QA
LL
V
F
DEV
QC
G
MG
RTG
D
LFA
YMHYGVT
PD
I
L
T
S
AK
A
L
G
GG
-
F
P
V
S
A
ML
T
T
AE
IA
S
A
FH
PG
S
--
---H
G
S
T
YG
GNPLA
C
A
V
A
G
A
A
F
DIINTPEVL
E
GIQAKRQ
R
F
V
D
H
L
QK
I
D
Q
QYDVFS
D
I
RG
M
G
fig|869729.3.peg.3604
Escherichia coli UM146 (18-339/406)
LPIYA
P
A
EFI
PVK
G
Q
G
SR
I
W
D
Q
Q
G
KE
YVD
FAG
GI
AVTAL
GH
C
HP
A
L
V
N
A
L
-
K
T
Q
GETLW
H
IS-NVFTN
E
PA
L
R
L
G
R
K
L
---I
E
ATFAER
V
VFMN
SG
T
EA
N
E
T
A
F
KLAR
HYACVRHSP
FK
TKI
I
A
F
H
N
A
F
HG
R
S
--------
LF
T
V
S
V
GGQ-PK
-
YSDGF
G
PK
P
A
D
IIHVPF-NDLHAVKA-------------
-
VMDDHT
C
A
VV
V
EP
I
-
QG
E
GG
VTAAT
PE
F
L
QG
LR
E
LCD
Q
H
QA
LL
V
F
DEV
QC
G
MG
RTG
D
LFA
YMHYGVT
PD
I
L
T
S
AK
A
L
G
GG
-
F
P
V
S
A
ML
T
T
AE
IA
S
A
FH
PG
S
--
---H
G
S
T
YG
GNPLA
C
A
V
A
G
A
A
F
DIINTPEVL
E
GIQAKRQ
R
F
V
D
H
L
QK
I
D
Q
QYDVFS
D
I
RG
M
G
fig|364106.7.peg.3780
Escherichia coli UTI89 (18-339/406)
LPIYA
P
A
EFI
PVK
G
Q
G
SR
I
W
D
Q
Q
G
KE
YVD
FAG
GI
AVTAL
GH
C
HP
A
L
V
N
A
L
-
K
T
Q
GETLW
H
IS-NVFTN
E
PA
L
R
L
G
R
K
L
---I
E
ATFAER
V
VFMN
SG
T
EA
N
E
T
A
F
KLAR
HYACVRHSP
FK
TKI
I
A
F
H
N
A
F
HG
R
S
--------
LF
T
V
S
V
GGQ-PK
-
YSDGF
G
PK
P
A
D
IIHVPF-NDLHAVKA-------------
-
VMDDHT
C
A
VV
V
EP
I
-
QG
E
GG
VTAAT
PE
F
L
QG
LR
E
LCD
Q
H
QA
LL
V
F
DEV
QC
G
MG
RTG
D
LFA
YMHYGVT
PD
I
L
T
S
AK
A
L
G
GG
-
F
P
V
S
A
ML
T
T
AE
IA
S
A
FH
PG
S
--
---H
G
S
T
YG
GNPLA
C
A
V
A
G
A
A
F
DIINTPEVL
E
GIQAKRQ
R
F
V
D
H
L
QK
I
D
Q
QYDVFS
D
I
RG
M
G
fig|364106.8.peg.3782
Escherichia coli UTI89 (18-339/406)
LPIYA
P
A
EFI
PVK
G
Q
G
SR
I
W
D
Q
Q
G
KE
YVD
FAG
GI
AVTAL
GH
C
HP
A
L
V
N
A
L
-
K
T
Q
GETLW
H
IS-NVFTN
E
PA
L
R
L
G
R
K
L
---I
E
ATFAER
V
VFMN
SG
T
EA
N
E
T
A
F
KLAR
HYACVRHSP
FK
TKI
I
A
F
H
N
A
F
HG
R
S
--------
LF
T
V
S
V
GGQ-PK
-
YSDGF
G
PK
P
A
D
IIHVPF-NDLHAVKA-------------
-
VMDDHT
C
A
VV
V
EP
I
-
QG
E
GG
VTAAT
PE
F
L
QG
LR
E
LCD
Q
H
QA
LL
V
F
DEV
QC
G
MG
RTG
D
LFA
YMHYGVT
PD
I
L
T
S
AK
A
L
G
GG
-
F
P
V
S
A
ML
T
T
AE
IA
S
A
FH
PG
S
--
---H
G
S
T
YG
GNPLA
C
A
V
A
G
A
A
F
DIINTPEVL
E
GIQAKRQ
R
F
V
D
H
L
QK
I
D
Q
QYDVFS
D
I
RG
M
G
fig|216592.1.peg.576
Escherichia coli 042 (18-339/406)
LPIYA
P
A
EFI
PVK
G
Q
G
SR
I
W
D
Q
Q
G
KE
YVD
FAG
GI
AVTAL
GH
C
HP
A
L
V
N
A
L
-
K
T
Q
GETLW
H
IS-NVFTN
E
PA
L
R
L
G
R
K
L
---I
E
ATFAER
V
VFMN
SG
T
EA
N
E
T
A
F
KLAR
HYACVRHSP
FK
TKI
I
A
F
H
N
A
F
HG
R
S
--------
LF
T
V
S
V
GGQ-PK
-
YSDGF
G
PK
P
A
D
IIHVPF-NDIHAVKA-------------
-
VMDDHT
C
A
VV
V
EP
I
-
QG
E
GG
VTAAT
PE
F
L
QG
LR
E
LCD
Q
H
QA
LL
V
F
DEV
QC
G
MG
RTG
D
LFA
YMHYGVT
PD
I
L
T
S
AK
A
L
G
GG
-
F
P
I
S
A
ML
T
T
AE
IA
S
A
FH
PG
S
--
---H
G
S
T
YG
GNPLA
C
A
V
A
G
A
A
F
DIINTPEVL
E
GIQAKRQ
R
F
V
D
H
L
QK
I
D
Q
QYDVFS
D
I
RG
M
G
fig|216592.3.peg.3761
Escherichia coli 042 (18-339/406)
LPIYA
P
A
EFI
PVK
G
Q
G
SR
I
W
D
Q
Q
G
KE
YVD
FAG
GI
AVTAL
GH
C
HP
A
L
V
N
A
L
-
K
T
Q
GETLW
H
IS-NVFTN
E
PA
L
R
L
G
R
K
L
---I
E
ATFAER
V
VFMN
SG
T
EA
N
E
T
A
F
KLAR
HYACVRHSP
FK
TKI
I
A
F
H
N
A
F
HG
R
S
--------
LF
T
V
S
V
GGQ-PK
-
YSDGF
G
PK
P
A
D
IIHVPF-NDIHAVKA-------------
-
VMDDHT
C
A
VV
V
EP
I
-
QG
E
GG
VTAAT
PE
F
L
QG
LR
E
LCD
Q
H
QA
LL
V
F
DEV
QC
G
MG
RTG
D
LFA
YMHYGVT
PD
I
L
T
S
AK
A
L
G
GG
-
F
P
I
S
A
ML
T
T
AE
IA
S
A
FH
PG
S
--
---H
G
S
T
YG
GNPLA
C
A
V
A
G
A
A
F
DIINTPEVL
E
GIQAKRQ
R
F
V
D
H
L
QK
I
D
Q
QYDVFS
D
I
RG
M
G
fig|656379.3.peg.4634
Escherichia coli FVEC1302 (18-339/406)
LPIYA
P
A
EFI
PVK
G
Q
G
SR
I
W
D
Q
Q
G
KE
YVD
FAG
GI
AVTAL
GH
C
HP
A
L
V
N
A
L
-
K
T
Q
GETLW
H
IS-NVFTN
E
PA
L
R
L
G
R
K
L
---I
E
ATFAER
V
VFMN
SG
T
EA
N
E
T
A
F
KLAR
HYACVRHSP
FK
TKI
I
A
F
H
N
A
F
HG
R
S
--------
LF
T
V
S
V
GGQ-PK
-
YSDGF
G
PK
P
A
D
IIHVPF-NDIHAVKA-------------
-
VMDDHT
C
A
VV
V
EP
I
-
QG
E
GG
VTAAT
PE
F
L
QG
LR
E
LCD
Q
H
QA
LL
V
F
DEV
QC
G
MG
RTG
D
LFA
YMHYGVT
PD
I
L
T
S
AK
A
L
G
GG
-
F
P
I
S
A
ML
T
T
AE
IA
S
A
FH
PG
S
--
---H
G
S
T
YG
GNPLA
C
A
V
A
G
A
A
F
DIINTPEVL
E
GIQAKRQ
R
F
V
D
H
L
QK
I
D
Q
QYDVFS
D
I
RG
M
G
fig|656380.3.peg.4422
Escherichia coli FVEC1412 (18-339/406)
LPIYA
P
A
EFI
PVK
G
Q
G
SR
I
W
D
Q
Q
G
KE
YVD
FAG
GI
AVTAL
GH
C
HP
A
L
V
N
A
L
-
K
T
Q
GETLW
H
IS-NVFTN
E
PA
L
R
L
G
R
K
L
---I
E
ATFAER
V
VFMN
SG
T
EA
N
E
T
A
F
KLAR
HYACVRHSP
FK
TKI
I
A
F
H
N
A
F
HG
R
S
--------
LF
T
V
S
V
GGQ-PK
-
YSDGF
G
PK
P
A
D
IIHVPF-NDIHAVKA-------------
-
VMDDHT
C
A
VV
V
EP
I
-
QG
E
GG
VTAAT
PE
F
L
QG
LR
E
LCD
Q
H
QA
LL
V
F
DEV
QC
G
MG
RTG
D
LFA
YMHYGVT
PD
I
L
T
S
AK
A
L
G
GG
-
F
P
I
S
A
ML
T
T
AE
IA
S
A
FH
PG
S
--
---H
G
S
T
YG
GNPLA
C
A
V
A
G
A
A
F
DIINTPEVL
E
GIQAKRQ
R
F
V
D
H
L
QK
I
D
Q
QYDVFS
D
I
RG
M
G
fig|749549.3.peg.811
Escherichia coli MS 198-1 (18-339/406)
LPIYA
P
A
EFI
PVK
G
Q
G
SR
I
W
D
Q
Q
G
KE
YVD
FAG
GI
AVTAL
GH
C
HP
A
L
V
N
A
L
-
K
T
Q
GETLW
H
IS-NVFTN
E
PA
L
R
L
G
R
K
L
---I
E
ATFAER
V
VFMN
SG
T
EA
N
E
T
A
F
KLAR
HYACVRHSP
FK
TKI
I
A
F
H
N
A
F
HG
R
S
--------
LF
T
V
S
V
GGQ-PK
-
YSDGF
G
PK
P
A
D
IIHVPF-NDIHAVKA-------------
-
VMDDHT
C
A
VV
V
EP
I
-
QG
E
GG
VTAAT
PE
F
L
QG
LR
E
LCD
Q
H
QA
LL
V
F
DEV
QC
G
MG
RTG
D
LFA
YMHYGVT
PD
I
L
T
S
AK
A
L
G
GG
-
F
P
I
S
A
ML
T
T
AE
IA
S
A
FH
PG
S
--
---H
G
S
T
YG
GNPLA
C
A
V
A
G
A
A
F
DIINTPEVL
E
GIQAKRQ
R
F
V
D
H
L
QK
I
D
Q
QYDVFS
D
I
RG
M
G
fig|749531.3.peg.1200
Escherichia coli MS 69-1 (18-339/407)
LPIYA
P
A
EFI
PVK
G
Q
G
SR
I
W
D
Q
Q
G
KE
YVD
FAG
GI
AVTAL
GH
C
HP
A
L
V
N
A
L
-
K
T
Q
GETLW
H
IS-NVFTN
E
PA
L
R
L
G
R
K
L
---I
E
ATFAER
V
VFMN
SG
T
EA
N
E
T
A
F
KLAR
HYACVRHSP
FK
TKI
I
A
F
H
N
A
F
HG
R
S
--------
LF
T
V
S
V
GGQ-PK
-
YSDGF
G
PK
P
A
D
IIHVPF-NDIHAVKA-------------
-
VMDDHT
C
A
VV
V
EP
I
-
QG
E
GG
VTAAT
PE
F
L
QG
LR
E
LCD
Q
H
QA
LL
V
F
DEV
QC
G
MG
RTG
D
LFA
YMHYGVT
PD
I
L
T
S
AK
A
L
G
GG
-
F
P
I
S
A
ML
T
T
AE
IA
S
A
FH
PG
S
--
---H
G
S
T
YG
GNPLA
C
A
V
A
G
A
A
F
DIINTPEVL
E
GIQAKRQ
R
F
V
D
H
L
QK
I
D
Q
QYDVFS
D
I
RG
M
G
fig|656437.3.peg.3773
Escherichia coli TA143 (18-339/406)
LPIYA
P
A
EFI
PVK
G
Q
G
SR
I
W
D
Q
Q
G
KE
YVD
FAG
GI
AVTAL
GH
C
HP
A
L
V
N
A
L
-
K
T
Q
GETLW
H
IS-NVFTN
E
PA
L
R
L
G
R
K
L
---I
E
ATFAER
V
VFMN
SG
T
EA
N
E
T
A
F
KLAR
HYACVRHSP
FK
TKI
I
A
F
H
N
A
F
HG
R
S
--------
LF
T
V
S
V
GGQ-PK
-
YSDGF
G
PK
P
A
D
IIHVPF-NDIHAVKA-------------
-
VMDDHT
C
A
VV
V
EP
I
-
QG
E
GG
VTAAT
PE
F
L
QG
LR
E
LCD
Q
H
QA
LL
V
F
DEV
QC
G
MG
RTG
D
LFA
YMHYGVT
PD
I
L
T
S
AK
A
L
G
GG
-
F
P
I
S
A
ML
T
T
AE
IA
S
A
FH
PG
S
--
---H
G
S
T
YG
GNPLA
C
A
V
A
G
A
A
F
DIINTPEVL
E
GIQAKRQ
R
F
V
D
H
L
QK
I
D
Q
QYDVFS
D
I
RG
M
G
fig|585056.7.peg.3994
Escherichia coli UMN026 (18-339/406)
LPIYA
P
A
EFI
PVK
G
Q
G
SR
I
W
D
Q
Q
G
KE
YVD
FAG
GI
AVTAL
GH
C
HP
A
L
V
N
A
L
-
K
T
Q
GETLW
H
IS-NVFTN
E
PA
L
R
L
G
R
K
L
---I
E
ATFAER
V
VFMN
SG
T
EA
N
E
T
A
F
KLAR
HYACVRHSP
FK
TKI
I
A
F
H
N
A
F
HG
R
S
--------
LF
T
V
S
V
GGQ-PK
-
YSDGF
G
PK
P
A
D
IIHVPF-NDIHAVKA-------------
-
VMDDHT
C
A
VV
V
EP
I
-
QG
E
GG
VTAAT
PE
F
L
QG
LR
E
LCD
Q
H
QA
LL
V
F
DEV
QC
G
MG
RTG
D
LFA
YMHYGVT
PD
I
L
T
S
AK
A
L
G
GG
-
F
P
I
S
A
ML
T
T
AE
IA
S
A
FH
PG
S
--
---H
G
S
T
YG
GNPLA
C
A
V
A
G
A
A
F
DIINTPEVL
E
GIQAKRQ
R
F
V
D
H
L
QK
I
D
Q
QYDVFS
D
I
RG
M
G
fig|525281.3.peg.2790
Escherichia coli 83972 (18-339/406)
LPIYA
P
A
EFI
PVK
G
Q
G
SR
I
W
D
Q
Q
G
KE
YVD
FAG
GI
AVTAL
GH
C
HP
A
L
V
N
A
L
-
K
T
Q
GETLW
H
IS-NVFTN
E
PA
L
R
L
G
R
K
L
---I
E
ATFAER
V
VFMN
SG
T
EA
N
E
T
A
F
KLAR
HYACVRHSP
FK
TKI
I
A
F
H
N
A
F
HG
R
S
--------
LF
T
V
S
V
GGQ-PK
-
YSDGF
G
PK
P
A
D
IIHVPF-NDLHAVKA-------------
-
VMDDHT
C
A
VV
V
EP
I
-
QG
E
GG
VTAAT
PE
F
L
QG
LR
E
LCD
Q
H
QA
LL
V
F
DEV
QC
G
MG
RTG
D
LFA
YMHYGVT
PD
I
L
T
S
AK
A
L
G
GG
-
F
P
V
S
A
ML
T
T
AE
IA
S
A
FH
PG
S
--
---H
G
S
T
YG
GNPLA
C
A
V
A
G
A
A
F
DIINTPEVL
E
GIQAKRQ
H
F
V
D
H
L
QK
I
D
Q
QYDVFS
D
I
RG
M
G
fig|655817.3.peg.3939
Escherichia coli ABU 83972 (18-339/406)
LPIYA
P
A
EFI
PVK
G
Q
G
SR
I
W
D
Q
Q
G
KE
YVD
FAG
GI
AVTAL
GH
C
HP
A
L
V
N
A
L
-
K
T
Q
GETLW
H
IS-NVFTN
E
PA
L
R
L
G
R
K
L
---I
E
ATFAER
V
VFMN
SG
T
EA
N
E
T
A
F
KLAR
HYACVRHSP
FK
TKI
I
A
F
H
N
A
F
HG
R
S
--------
LF
T
V
S
V
GGQ-PK
-
YSDGF
G
PK
P
A
D
IIHVPF-NDLHAVKA-------------
-
VMDDHT
C
A
VV
V
EP
I
-
QG
E
GG
VTAAT
PE
F
L
QG
LR
E
LCD
Q
H
QA
LL
V
F
DEV
QC
G
MG
RTG
D
LFA
YMHYGVT
PD
I
L
T
S
AK
A
L
G
GG
-
F
P
V
S
A
ML
T
T
AE
IA
S
A
FH
PG
S
--
---H
G
S
T
YG
GNPLA
C
A
V
A
G
A
A
F
DIINTPEVL
E
GIQAKRQ
H
F
V
D
H
L
QK
I
D
Q
QYDVFS
D
I
RG
M
G
fig|199310.1.peg.4041
Escherichia coli CFT073 (18-339/406)
LPIYA
P
A
EFI
PVK
G
Q
G
SR
I
W
D
Q
Q
G
KE
YVD
FAG
GI
AVTAL
GH
C
HP
A
L
V
N
A
L
-
K
T
Q
GETLW
H
IS-NVFTN
E
PA
L
R
L
G
R
K
L
---I
E
ATFAER
V
VFMN
SG
T
EA
N
E
T
A
F
KLAR
HYACVRHSP
FK
TKI
I
A
F
H
N
A
F
HG
R
S
--------
LF
T
V
S
V
GGQ-PK
-
YSDGF
G
PK
P
A
D
IIHVPF-NDLHAVKA-------------
-
VMDDHT
C
A
VV
V
EP
I
-
QG
E
GG
VTAAT
PE
F
L
QG
LR
E
LCD
Q
H
QA
LL
V
F
DEV
QC
G
MG
RTG
D
LFA
YMHYGVT
PD
I
L
T
S
AK
A
L
G
GG
-
F
P
V
S
A
ML
T
T
AE
IA
S
A
FH
PG
S
--
---H
G
S
T
YG
GNPLA
C
A
V
A
G
A
A
F
DIINTPEVL
E
GIQAKRQ
H
F
V
D
H
L
QK
I
D
Q
QYDVFS
D
I
RG
M
G
fig|199310.4.peg.3885
Escherichia coli CFT073 (18-339/406)
LPIYA
P
A
EFI
PVK
G
Q
G
SR
I
W
D
Q
Q
G
KE
YVD
FAG
GI
AVTAL
GH
C
HP
A
L
V
N
A
L
-
K
T
Q
GETLW
H
IS-NVFTN
E
PA
L
R
L
G
R
K
L
---I
E
ATFAER
V
VFMN
SG
T
EA
N
E
T
A
F
KLAR
HYACVRHSP
FK
TKI
I
A
F
H
N
A
F
HG
R
S
--------
LF
T
V
S
V
GGQ-PK
-
YSDGF
G
PK
P
A
D
IIHVPF-NDLHAVKA-------------
-
VMDDHT
C
A
VV
V
EP
I
-
QG
E
GG
VTAAT
PE
F
L
QG
LR
E
LCD
Q
H
QA
LL
V
F
DEV
QC
G
MG
RTG
D
LFA
YMHYGVT
PD
I
L
T
S
AK
A
L
G
GG
-
F
P
V
S
A
ML
T
T
AE
IA
S
A
FH
PG
S
--
---H
G
S
T
YG
GNPLA
C
A
V
A
G
A
A
F
DIINTPEVL
E
GIQAKRQ
H
F
V
D
H
L
QK
I
D
Q
QYDVFS
D
I
RG
M
G
fig|749546.3.peg.4132
Escherichia coli MS 185-1 (18-339/406)
LPIYA
P
A
EFI
PVK
G
Q
G
SR
I
W
D
Q
Q
G
KE
YVD
FAG
GI
AVTAL
GH
C
HP
A
L
V
N
A
L
-
K
T
Q
GETLW
H
IS-NVFTN
E
PA
L
R
L
G
R
K
L
---I
E
ATFAER
V
VFMN
SG
T
EA
N
E
T
A
F
KLAR
HYACVRHSP
FK
TKI
I
A
F
H
N
A
F
HG
R
S
--------
LF
T
V
S
V
GGQ-PK
-
YSDGF
G
PK
P
A
D
IIHVPF-NDLHAVKA-------------
-
VMDDHT
C
A
VV
V
EP
I
-
QG
E
GG
VTAAT
PE
F
L
QG
LR
E
LCD
Q
H
QA
LL
V
F
DEV
QC
G
MG
RTG
D
LFA
YMHYGVT
PD
I
L
T
S
AK
A
L
G
GG
-
F
P
V
S
A
ML
T
T
AE
IA
S
A
FH
PG
S
--
---H
G
S
T
YG
GNPLA
C
A
V
A
G
A
A
F
DIINTPEVL
E
GIQAKRQ
H
F
V
D
H
L
QK
I
D
Q
QYDVFS
D
I
RG
M
G
fig|749528.3.peg.844
Escherichia coli MS 45-1 (18-339/406)
LPIYA
P
A
EFI
PVK
G
Q
G
SR
I
W
D
Q
Q
G
KE
YVD
FAG
GI
AVTAL
GH
C
HP
A
L
V
N
A
L
-
K
T
Q
GETLW
H
IS-NVFTN
E
PA
L
R
L
G
R
K
L
---I
E
ATFAER
V
VFMN
SG
T
EA
N
E
T
A
F
KLAR
HYACVRHSP
FK
TKI
I
A
F
H
N
A
F
HG
R
S
--------
LF
T
V
S
V
GGQ-PK
-
YSDGF
G
PK
P
A
D
IIHVPF-NDLHAVKA-------------
-
VMDDHT
C
A
VV
V
EP
I
-
QG
E
GG
VTAAT
PE
F
L
QG
LR
E
LCD
Q
H
QA
LL
V
F
DEV
QC
G
MG
RTG
D
LFA
YMHYGVT
PD
I
L
T
S
AK
A
L
G
GG
-
F
P
V
S
A
ML
T
T
AE
IA
S
A
FH
PG
S
--
---H
G
S
T
YG
GNPLA
C
A
V
A
G
A
A
F
DIINTPEVL
E
GIQAKRQ
H
F
V
D
H
L
QK
I
D
Q
QYDVFS
D
I
RG
M
G
fig|753642.3.peg.4604
Escherichia coli NC101 (18-339/406)
LPIYA
P
A
EFI
PVK
G
Q
G
SR
I
W
D
Q
Q
G
KE
YVD
FAG
GI
AVTAL
GH
C
HP
A
L
V
N
A
L
-
K
T
Q
GETLW
H
IS-NVFTN
E
PA
L
R
L
G
R
K
L
---I
E
ATFAER
V
VFMN
SG
T
EA
N
E
T
A
F
KLAR
HYACVRHSP
FK
TKI
I
A
F
H
N
A
F
HG
R
S
--------
LF
T
V
S
V
GGQ-PK
-
YSDGF
G
PK
P
A
D
IIHVPF-NDLHAVKA-------------
-
VMDDHT
C
A
VV
V
EP
I
-
QG
E
GG
VTAAT
PE
F
L
QG
LR
E
LCD
Q
H
QA
LL
V
F
DEV
QC
G
MG
RTG
D
LFA
YMHYGVT
PD
I
L
T
S
AK
A
L
G
GG
-
F
P
V
S
A
ML
T
T
AE
IA
S
A
FH
PG
S
--
---H
G
S
T
YG
GNPLA
C
A
V
A
G
A
A
F
DIINTPEVL
E
GIQAKRQ
H
F
V
D
H
L
QK
I
D
Q
QYDVFS
D
I
RG
M
G
fig|550676.3.peg.3489
Escherichia coli B185 (18-339/406)
LPIYA
P
A
EFI
PVK
G
Q
G
SR
I
W
D
Q
Q
G
KE
YVD
FAG
GI
AVTAL
GH
C
HP
A
L
V
N
A
L
-
K
T
Q
GETLW
H
IS-NVFTN
E
PA
L
R
L
G
R
K
L
---I
E
ATFAER
V
VFMN
SG
T
EA
N
E
T
A
F
KLAR
HYACVRHSP
FK
TKI
I
A
F
H
N
A
F
HG
R
S
--------
LF
T
V
S
V
GGQ-PK
-
YSDGF
G
PK
P
A
D
IIHVPF-NDLHAVKA-------------
-
VMDDHT
C
A
VV
V
EP
I
-
QG
E
GG
VMAAM
PE
F
L
QG
LR
E
LCD
Q
Y
QA
LL
V
F
DEV
QC
G
MG
RTG
D
LFA
YMHYGVT
PD
I
L
T
S
AK
A
L
G
GG
-
F
P
I
S
A
ML
T
T
AE
IA
S
A
FH
PG
S
--
---H
G
S
T
YG
GNPLA
C
A
V
A
G
A
A
F
DIINTPEVL
E
GIQAKRQ
R
F
V
D
H
L
QK
I
D
Q
QYDVFS
D
I
RG
M
G
fig|656419.3.peg.4324
Escherichia coli M718 (18-339/406)
LPIYA
P
A
EFI
PVK
G
Q
G
SR
I
W
D
Q
Q
G
KE
YVD
FAG
GI
AVTAL
GH
C
HP
A
L
V
N
A
L
-
K
T
Q
GETLW
H
IS-NVFTN
E
PA
L
R
L
G
R
K
L
---I
E
ATFAER
V
VFMN
SG
T
EA
N
E
T
A
F
KLAR
HYACVRHSP
FK
TKI
I
A
F
H
N
A
F
HG
R
S
--------
LF
T
V
S
V
GGQ-PK
-
YSDGF
G
PK
P
A
D
IIHVPF-NDLHAVKA-------------
-
VMDDHT
C
A
VV
V
EP
I
-
QG
E
GG
VMAAM
PE
F
L
QG
LR
E
LCD
Q
Y
QA
LL
V
F
DEV
QC
G
MG
RTG
D
LFA
YMHYGVT
PD
I
L
T
S
AK
A
L
G
GG
-
F
P
I
S
A
ML
T
T
AE
IA
S
A
FH
PG
S
--
---H
G
S
T
YG
GNPLA
C
A
V
A
G
A
A
F
DIINTPEVL
E
GIQAKRQ
R
F
V
D
H
L
QK
I
D
Q
QYDVFS
D
I
RG
M
G
fig|550677.3.peg.3909
Escherichia coli B354 (18-339/406)
LPIYA
P
A
EFI
PVK
G
Q
G
SR
I
W
D
Q
Q
G
KE
YVD
FAG
GI
AVTAL
GH
C
HP
A
L
V
N
A
L
-
K
T
Q
GETLW
H
IS-NVFTN
E
PA
L
R
L
G
R
K
L
---I
E
ATFAER
V
VFMS
SG
T
EA
N
E
T
A
F
KLAR
HYACVRHSP
FK
TKI
I
A
F
H
N
A
F
HG
R
S
--------
LF
T
V
S
V
GGQ-PK
-
YSDGF
G
PK
P
A
D
IIHIPF-NDLHAVKA-------------
-
VMDDHT
C
A
VV
V
EP
I
-
QG
E
GG
VTAAT
PE
F
L
QG
LR
E
LCD
Q
H
QA
LL
V
F
DEV
QC
G
MG
RTG
D
LFA
YMHYGVT
PD
I
L
T
S
AK
A
L
G
GG
-
F
P
I
S
A
ML
T
T
AE
IA
S
A
FH
PG
S
--
---H
G
S
T
YG
GNPLA
C
A
V
A
G
A
A
F
DIINTPEVL
E
GIQAKRQ
R
F
V
D
H
L
QK
I
D
Q
QYDVFS
D
I
RG
M
G
fig|344601.3.peg.1187
Escherichia coli B171 (18-339/406)
LPIYA
P
A
EFI
PVK
G
Q
G
SR
I
W
D
Q
Q
G
KE
YVD
FAG
GI
AVTAL
GH
C
HP
A
L
V
N
A
L
-
K
T
Q
GETLW
H
IS-NVFTN
E
PA
L
R
L
G
R
K
L
---I
E
ATFAER
V
VFMN
SG
T
EA
N
E
T
A
F
KLAR
HYACVRHSP
FK
TKI
I
A
F
H
N
A
F
HG
R
S
--------
LF
T
V
S
V
GGQ-PK
-
YSDGF
G
PK
P
A
D
IIHVPF-NDLHAVKA-------------
-
VMDDHT
C
A
VV
V
EP
I
-
QG
E
GG
VTAAT
PE
F
L
QG
LR
E
LCD
Q
H
QA
LL
V
F
DEV
QC
G
MG
RTG
D
LFA
YMHYGVT
PD
I
L
T
S
AK
A
L
G
GG
-
F
P
I
S
A
ML
T
T
AE
IA
S
A
FH
PG
S
--
---H
G
S
T
YG
GNPL
S
C
A
V
A
G
A
A
F
DIINTPEVL
E
GIQAKRQ
R
F
V
D
H
L
QK
I
D
Q
QYDVFS
D
I
RG
M
G
fig|344601.5.peg.1252
Escherichia coli B171 (18-339/406)
LPIYA
P
A
EFI
PVK
G
Q
G
SR
I
W
D
Q
Q
G
KE
YVD
FAG
GI
AVTAL
GH
C
HP
A
L
V
N
A
L
-
K
T
Q
GETLW
H
IS-NVFTN
E
PA
L
R
L
G
R
K
L
---I
E
ATFAER
V
VFMN
SG
T
EA
N
E
T
A
F
KLAR
HYACVRHSP
FK
TKI
I
A
F
H
N
A
F
HG
R
S
--------
LF
T
V
S
V
GGQ-PK
-
YSDGF
G
PK
P
A
D
IIHVPF-NDLHAVKA-------------
-
VMDDHT
C
A
VV
V
EP
I
-
QG
E
GG
VTAAT
PE
F
L
QG
LR
E
LCD
Q
H
QA
LL
V
F
DEV
QC
G
MG
RTG
D
LFA
YMHYGVT
PD
I
L
T
S
AK
A
L
G
GG
-
F
P
I
S
A
ML
T
T
AE
IA
S
A
FH
PG
S
--
---H
G
S
T
YG
GNPL
S
C
A
V
A
G
A
A
F
DIINTPEVL
E
GIQAKRQ
R
F
V
D
H
L
QK
I
D
Q
QYDVFS
D
I
RG
M
G
fig|340186.3.peg.1928
Escherichia coli E110019 (18-339/406)
LPIYA
P
A
EFI
PVK
G
Q
G
SR
I
W
D
Q
Q
G
KE
YVD
FAG
GI
AVTAL
GH
C
HP
A
L
V
N
A
L
-
K
T
Q
GETLW
H
IS-NVFTN
E
PA
L
R
L
G
R
K
L
---I
E
ATFAER
V
VFMN
SG
T
EA
N
E
T
A
F
KLAR
HYACVRHSP
FK
TKI
I
A
F
H
N
A
F
HG
R
S
--------
LF
T
V
S
V
GGQ-PK
-
YSDGF
G
PK
P
A
D
IIHVPF-NDLHAVKA-------------
-
VMDDHT
C
A
VV
V
EP
I
-
QG
E
GG
VTAAT
PE
F
L
QG
LR
E
LCD
Q
H
QA
LL
V
F
DEV
QC
G
MG
RTG
D
LFA
YMHYGVT
PD
I
L
T
S
AK
A
L
G
GG
-
F
P
I
S
A
ML
T
T
AE
IA
S
A
FH
PG
S
--
---H
G
S
T
YG
GNPL
S
C
A
V
A
G
A
A
F
DIINTPEVL
E
GIQAKRQ
R
F
V
D
H
L
QK
I
D
Q
QYDVFS
D
I
RG
M
G
fig|340186.5.peg.1994
Escherichia coli E110019 (18-339/406)
LPIYA
P
A
EFI
PVK
G
Q
G
SR
I
W
D
Q
Q
G
KE
YVD
FAG
GI
AVTAL
GH
C
HP
A
L
V
N
A
L
-
K
T
Q
GETLW
H
IS-NVFTN
E
PA
L
R
L
G
R
K
L
---I
E
ATFAER
V
VFMN
SG
T
EA
N
E
T
A
F
KLAR
HYACVRHSP
FK
TKI
I
A
F
H
N
A
F
HG
R
S
--------
LF
T
V
S
V
GGQ-PK
-
YSDGF
G
PK
P
A
D
IIHVPF-NDLHAVKA-------------
-
VMDDHT
C
A
VV
V
EP
I
-
QG
E
GG
VTAAT
PE
F
L
QG
LR
E
LCD
Q
H
QA
LL
V
F
DEV
QC
G
MG
RTG
D
LFA
YMHYGVT
PD
I
L
T
S
AK
A
L
G
GG
-
F
P
I
S
A
ML
T
T
AE
IA
S
A
FH
PG
S
--
---H
G
S
T
YG
GNPL
S
C
A
V
A
G
A
A
F
DIINTPEVL
E
GIQAKRQ
R
F
V
D
H
L
QK
I
D
Q
QYDVFS
D
I
RG
M
G
fig|340185.3.peg.253
Escherichia coli E22 (18-339/406)
LPIYA
P
A
EFI
PVK
G
Q
G
SR
I
W
D
Q
Q
G
KE
YVD
FAG
GI
AVTAL
GH
C
HP
A
L
V
N
A
L
-
K
T
Q
GETLW
H
IS-NVFTN
E
PA
L
R
L
G
R
K
L
---I
E
ATFAER
V
VFMN
SG
T
EA
N
E
T
A
F
KLAR
HYACVRHSP
FK
TKI
I
A
F
H
N
A
F
HG
R
S
--------
LF
T
V
S
V
GGQ-PK
-
YSDGF
G
PK
P
A
D
IIHVPF-NDLHAVKA-------------
-
VMDDHT
C
A
VV
V
EP
I
-
QG
E
GG
VTAAT
PE
F
L
QG
LR
E
LCD
Q
H
QA
LL
V
F
DEV
QC
G
MG
RTG
D
LFA
YMHYGVT
PD
I
L
T
S
AK
A
L
G
GG
-
F
P
I
S
A
ML
T
T
AE
IA
S
A
FH
PG
S
--
---H
G
S
T
YG
GNPL
S
C
A
V
A
G
A
A
F
DIINTPEVL
E
GIQAKRQ
R
F
V
D
H
L
QK
I
D
Q
QYDVFS
D
I
RG
M
G
fig|340185.4.peg.271
Escherichia coli E22 (18-339/406)
LPIYA
P
A
EFI
PVK
G
Q
G
SR
I
W
D
Q
Q
G
KE
YVD
FAG
GI
AVTAL
GH
C
HP
A
L
V
N
A
L
-
K
T
Q
GETLW
H
IS-NVFTN
E
PA
L
R
L
G
R
K
L
---I
E
ATFAER
V
VFMN
SG
T
EA
N
E
T
A
F
KLAR
HYACVRHSP
FK
TKI
I
A
F
H
N
A
F
HG
R
S
--------
LF
T
V
S
V
GGQ-PK
-
YSDGF
G
PK
P
A
D
IIHVPF-NDLHAVKA-------------
-
VMDDHT
C
A
VV
V
EP
I
-
QG
E
GG
VTAAT
PE
F
L
QG
LR
E
LCD
Q
H
QA
LL
V
F
DEV
QC
G
MG
RTG
D
LFA
YMHYGVT
PD
I
L
T
S
AK
A
L
G
GG
-
F
P
I
S
A
ML
T
T
AE
IA
S
A
FH
PG
S
--
---H
G
S
T
YG
GNPL
S
C
A
V
A
G
A
A
F
DIINTPEVL
E
GIQAKRQ
R
F
V
D
H
L
QK
I
D
Q
QYDVFS
D
I
RG
M
G
fig|595495.4.peg.1564
Escherichia coli KO11 (18-339/406)
LPIYA
P
A
EFI
PVK
G
Q
G
SR
I
W
D
Q
Q
G
KE
YVD
FAG
GI
AVTAL
GH
C
HP
A
L
V
N
A
L
-
K
T
Q
GETLW
H
IS-NVFTN
E
PA
L
R
L
G
R
K
L
---I
E
ATFAER
V
VFMN
SG
T
EA
N
E
T
A
F
KLAR
HYACVRHSP
FK
TKI
I
A
F
H
N
A
F
HG
R
S
--------
LF
T
V
S
V
GGQ-PK
-
YSDGF
G
PK
P
A
D
IIHVPF-NDLHAVKA-------------
-
VMDDHT
C
A
VV
V
EP
I
-
QG
E
GG
VTAAT
PE
F
L
QG
LR
E
LCD
Q
H
QA
LL
V
F
DEV
QC
G
MG
RTG
D
LFA
YMHYGVT
PD
I
L
T
S
AK
A
L
G
GG
-
F
P
I
S
A
ML
T
T
AE
IA
S
A
FH
PG
S
--
---H
G
S
T
YG
GNPL
S
C
A
V
A
G
A
A
F
DIINTPEVL
E
GIQAKRQ
R
F
V
D
H
L
QK
I
D
Q
QYDVFS
D
I
RG
M
G
fig|679207.4.peg.457
Escherichia coli MS 107-1 (18-339/406)
LPIYA
P
A
EFI
PVK
G
Q
G
SR
I
W
D
Q
Q
G
KE
YVD
FAG
GI
AVTAL
GH
C
HP
A
L
V
N
A
L
-
K
T
Q
GETLW
H
IS-NVFTN
E
PA
L
R
L
G
R
K
L
---I
E
ATFAER
V
VFMN
SG
T
EA
N
E
T
A
F
KLAR
HYACVRHSP
FK
TKI
I
A
F
H
N
A
F
HG
R
S
--------
LF
T
V
S
V
GGQ-PK
-
YSDGF
G
PK
P
A
D
IIHVPF-NDLHAVKA-------------
-
VMDDHT
C
A
VV
V
EP
I
-
QG
E
GG
VTAAT
PE
F
L
QG
LR
E
LCD
Q
H
QA
LL
V
F
DEV
QC
G
MG
RTG
D
LFA
YMHYGVT
PD
I
L
T
S
AK
A
L
G
GG
-
F
P
I
S
A
ML
T
T
AE
IA
S
A
FH
PG
S
--
---H
G
S
T
YG
GNPL
S
C
A
V
A
G
A
A
F
DIINTPEVL
E
GIQAKRQ
R
F
V
D
H
L
QK
I
D
Q
QYDVFS
D
I
RG
M
G
fig|679204.3.peg.1763
Escherichia coli MS 145-7 (18-339/406)
LPIYA
P
A
EFI
PVK
G
Q
G
SR
I
W
D
Q
Q
G
KE
YVD
FAG
GI
AVTAL
GH
C
HP
A
L
V
N
A
L
-
K
T
Q
GETLW
H
IS-NVFTN
E
PA
L
R
L
G
R
K
L
---I
E
ATFAER
V
VFMN
SG
T
EA
N
E
T
A
F
KLAR
HYACVRHSP
FK
TKI
I
A
F
H
N
A
F
HG
R
S
--------
LF
T
V
S
V
GGQ-PK
-
YSDGF
G
PK
P
A
D
IIHVPF-NDLHAVKA-------------
-
VMDDHT
C
A
VV
V
EP
I
-
QG
E
GG
VTAAT
PE
F
L
QG
LR
E
LCD
Q
H
QA
LL
V
F
DEV
QC
G
MG
RTG
D
LFA
YMHYGVT
PD
I
L
T
S
AK
A
L
G
GG
-
F
P
I
S
A
ML
T
T
AE
IA
S
A
FH
PG
S
--
---H
G
S
T
YG
GNPL
S
C
A
V
A
G
A
A
F
DIINTPEVL
E
GIQAKRQ
R
F
V
D
H
L
QK
I
D
Q
QYDVFS
D
I
RG
M
G
fig|749545.3.peg.4552
Escherichia coli MS 182-1 (18-339/406)
LPIYA
P
A
EFI
PVK
G
Q
G
SR
I
W
D
Q
Q
G
KE
YVD
FAG
GI
AVTAL
GH
C
HP
A
L
V
N
A
L
-
K
T
Q
GETLW
H
IS-NVFTN
E
PA
L
R
L
G
R
K
L
---I
E
ATFAER
V
VFMN
SG
T
EA
N
E
T
A
F
KLAR
HYACVRHSP
FK
TKI
I
A
F
H
N
A
F
HG
R
S
--------
LF
T
V
S
V
GGQ-PK
-
YSDGF
G
PK
P
A
D
IIHVPF-NDLHAVKA-------------
-
VMDDHT
C
A
VV
V
EP
I
-
QG
E
GG
VTAAT
PE
F
L
QG
LR
E
LCD
Q
H
QA
LL
V
F
DEV
QC
G
MG
RTG
D
LFA
YMHYGVT
PD
I
L
T
S
AK
A
L
G
GG
-
F
P
I
S
A
ML
T
T
AE
IA
S
A
FH
PG
S
--
---H
G
S
T
YG
GNPL
S
C
A
V
A
G
A
A
F
DIINTPEVL
E
GIQAKRQ
R
F
V
D
H
L
QK
I
D
Q
QYDVFS
D
I
RG
M
G
fig|749532.3.peg.3907
Escherichia coli MS 78-1 (18-339/406)
LPIYA
P
A
EFI
PVK
G
Q
G
SR
I
W
D
Q
Q
G
KE
YVD
FAG
GI
AVTAL
GH
C
HP
A
L
V
N
A
L
-
K
T
Q
GETLW
H
IS-NVFTN
E
PA
L
R
L
G
R
K
L
---I
E
ATFAER
V
VFMN
SG
T
EA
N
E
T
A
F
KLAR
HYACVRHSP
FK
TKI
I
A
F
H
N
A
F
HG
R
S
--------
LF
T
V
S
V
GGQ-PK
-
YSDGF
G
PK
P
A
D
IIHVPF-NDLHAVKA-------------
-
VMDDHT
C
A
VV
V
EP
I
-
QG
E
GG
VTAAT
PE
F
L
QG
LR
E
LCD
Q
H
QA
LL
V
F
DEV
QC
G
MG
RTG
D
LFA
YMHYGVT
PD
I
L
T
S
AK
A
L
G
GG
-
F
P
I
S
A
ML
T
T
AE
IA
S
A
FH
PG
S
--
---H
G
S
T
YG
GNPL
S
C
A
V
A
G
A
A
F
DIINTPEVL
E
GIQAKRQ
R
F
V
D
H
L
QK
I
D
Q
QYDVFS
D
I
RG
M
G
fig|585395.4.peg.4262
Escherichia coli O103:H2 str. 12009 (18-339/406)
LPIYA
P
A
EFI
PVK
G
Q
G
SR
I
W
D
Q
Q
G
KE
YVD
FAG
GI
AVTAL
GH
C
HP
A
L
V
N
A
L
-
K
T
Q
GETLW
H
IS-NVFTN
E
PA
L
R
L
G
R
K
L
---I
E
ATFAER
V
VFMN
SG
T
EA
N
E
T
A
F
KLAR
HYACVRHSP
FK
TKI
I
A
F
H
N
A
F
HG
R
S
--------
LF
T
V
S
V
GGQ-PK
-
YSDGF
G
PK
P
A
D
IIHVPF-NDLHAVKA-------------
-
VMDDHT
C
A
VV
V
EP
I
-
QG
E
GG
VTAAT
PE
F
L
QG
LR
E
LCD
Q
H
QA
LL
V
F
DEV
QC
G
MG
RTG
D
LFA
YMHYGVT
PD
I
L
T
S
AK
A
L
G
GG
-
F
P
I
S
A
ML
T
T
AE
IA
S
A
FH
PG
S
--
---H
G
S
T
YG
GNPL
S
C
A
V
A
G
A
A
F
DIINTPEVL
E
GIQAKRQ
R
F
V
D
H
L
QK
I
D
Q
QYDVFS
D
I
RG
M
G
fig|566546.3.peg.2123
Escherichia coli W (18-339/406)
LPIYA
P
A
EFI
PVK
G
Q
G
SR
I
W
D
Q
Q
G
KE
YVD
FAG
GI
AVTAL
GH
C
HP
A
L
V
N
A
L
-
K
T
Q
GETLW
H
IS-NVFTN
E
PA
L
R
L
G
R
K
L
---I
E
ATFAER
V
VFMN
SG
T
EA
N
E
T
A
F
KLAR
HYACVRHSP
FK
TKI
I
A
F
H
N
A
F
HG
R
S
--------
LF
T
V
S
V
GGQ-PK
-
YSDGF
G
PK
P
A
D
IIHVPF-NDLHAVKA-------------
-
VMDDHT
C
A
VV
V
EP
I
-
QG
E
GG
VTAAT
PE
F
L
QG
LR
E
LCD
Q
H
QA
LL
V
F
DEV
QC
G
MG
RTG
D
LFA
YMHYGVT
PD
I
L
T
S
AK
A
L
G
GG
-
F
P
I
S
A
ML
T
T
AE
IA
S
A
FH
PG
S
--
---H
G
S
T
YG
GNPL
S
C
A
V
A
G
A
A
F
DIINTPEVL
E
GIQAKRQ
R
F
V
D
H
L
QK
I
D
Q
QYDVFS
D
I
RG
M
G
fig|566546.4.peg.3569
Escherichia coli W (18-339/406)
LPIYA
P
A
EFI
PVK
G
Q
G
SR
I
W
D
Q
Q
G
KE
YVD
FAG
GI
AVTAL
GH
C
HP
A
L
V
N
A
L
-
K
T
Q
GETLW
H
IS-NVFTN
E
PA
L
R
L
G
R
K
L
---I
E
ATFAER
V
VFMN
SG
T
EA
N
E
T
A
F
KLAR
HYACVRHSP
FK
TKI
I
A
F
H
N
A
F
HG
R
S
--------
LF
T
V
S
V
GGQ-PK
-
YSDGF
G
PK
P
A
D
IIHVPF-NDLHAVKA-------------
-
VMDDHT
C
A
VV
V
EP
I
-
QG
E
GG
VTAAT
PE
F
L
QG
LR
E
LCD
Q
H
QA
LL
V
F
DEV
QC
G
MG
RTG
D
LFA
YMHYGVT
PD
I
L
T
S
AK
A
L
G
GG
-
F
P
I
S
A
ML
T
T
AE
IA
S
A
FH
PG
S
--
---H
G
S
T
YG
GNPL
S
C
A
V
A
G
A
A
F
DIINTPEVL
E
GIQAKRQ
R
F
V
D
H
L
QK
I
D
Q
QYDVFS
D
I
RG
M
G
fig|656414.3.peg.3837
Escherichia coli H736 (18-339/406)
LPIYA
P
A
EFI
PVK
G
Q
G
SR
I
W
D
Q
Q
G
KE
YVD
FAG
GI
AVTAL
GH
C
HP
A
L
V
N
A
L
-
K
T
Q
GETLW
H
IS-NVFTN
E
PA
L
R
L
G
R
K
L
---I
E
ATFAER
V
VFMN
SG
T
EA
N
E
T
A
F
KLAR
HYACVRHSP
FK
TKI
I
A
F
H
N
A
F
HG
R
S
--------
LF
T
V
S
V
GGQ-PK
-
YSDGF
G
PK
P
A
D
IIHVPF-NDLHAVKA-------------
-
VMDDHT
C
A
VV
V
EP
I
-
QG
E
GG
VTAAT
PE
F
L
QG
LR
E
LCD
Q
H
QA
LL
V
F
DEV
QC
G
MG
RTG
D
LF
T
YMHYGVT
PD
I
L
T
S
AK
A
L
G
GG
-
F
P
I
S
A
ML
T
T
AE
IA
S
A
FH
PG
S
--
---H
G
S
T
YG
GNPLA
C
A
V
A
G
A
A
F
DIINTPEVL
E
GIQAKRQ
R
F
V
D
H
L
QK
I
D
Q
QYDVFS
D
I
RG
M
G
fig|585397.7.peg.4011
Escherichia coli ED1a (18-339/406)
LPIYA
P
A
EFI
PVK
G
Q
G
SR
I
W
D
Q
Q
G
KE
YVD
FAG
GI
AVTAL
GH
C
HP
A
L
V
N
A
L
-
K
T
Q
GETLW
H
IS-NVFTN
E
PA
L
R
L
G
R
K
L
---I
E
ATFAER
V
VFMN
SG
T
EA
N
E
T
A
F
KLAR
HYACVRHSP
FK
TKI
I
A
F
H
N
A
F
HG
R
S
--------
LF
T
V
S
V
GGQ-PK
-
YSDGF
G
PK
P
A
D
IIHVPF-NELHAVKA-------------
-
VMDDHT
C
A
VV
V
EP
I
-
QG
E
GG
VTAAT
PE
F
L
QG
LR
E
LCD
Q
H
QA
LL
V
F
DEV
QC
G
MG
R
I
G
D
LFA
YMHYGVT
PD
I
L
T
S
AK
A
L
G
GG
-
F
P
V
S
A
ML
T
T
AE
IA
S
A
FH
PG
S
--
---H
G
S
T
YG
GNPLA
C
A
V
A
G
A
A
F
DIINTPEVL
E
GIQAKRQ
R
F
V
D
H
L
QK
I
D
Q
QYDVFS
D
I
RG
M
G
fig|585397.9.peg.4008
Escherichia coli ED1a (18-339/406)
LPIYA
P
A
EFI
PVK
G
Q
G
SR
I
W
D
Q
Q
G
KE
YVD
FAG
GI
AVTAL
GH
C
HP
A
L
V
N
A
L
-
K
T
Q
GETLW
H
IS-NVFTN
E
PA
L
R
L
G
R
K
L
---I
E
ATFAER
V
VFMN
SG
T
EA
N
E
T
A
F
KLAR
HYACVRHSP
FK
TKI
I
A
F
H
N
A
F
HG
R
S
--------
LF
T
V
S
V
GGQ-PK
-
YSDGF
G
PK
P
A
D
IIHVPF-NELHAVKA-------------
-
VMDDHT
C
A
VV
V
EP
I
-
QG
E
GG
VTAAT
PE
F
L
QG
LR
E
LCD
Q
H
QA
LL
V
F
DEV
QC
G
MG
R
I
G
D
LFA
YMHYGVT
PD
I
L
T
S
AK
A
L
G
GG
-
F
P
V
S
A
ML
T
T
AE
IA
S
A
FH
PG
S
--
---H
G
S
T
YG
GNPLA
C
A
V
A
G
A
A
F
DIINTPEVL
E
GIQAKRQ
R
F
V
D
H
L
QK
I
D
Q
QYDVFS
D
I
RG
M
G
fig|670888.3.peg.2892
Escherichia coli 1827-70 (18-339/406)
LPIYA
P
A
EFI
PVK
G
Q
G
SR
I
W
D
Q
Q
G
KE
YVD
FAG
GI
AVTAL
GH
C
HP
A
L
V
N
A
L
-
K
T
Q
GETLW
H
IS-NVFTN
E
PA
L
R
L
G
H
K
L
---I
E
ATFAER
V
VFMN
SG
T
EA
N
E
T
A
F
KLAR
HYACVRHSP
FK
TKI
I
A
F
H
N
A
F
HG
R
S
--------
LF
T
V
S
V
GGQ-PK
-
YSDGF
G
PK
P
A
D
IIHVPF-NDLHAVKA-------------
-
VMDDHT
C
A
VV
V
EP
I
-
QG
E
GG
VTAAT
PE
F
L
QG
LR
E
LCD
Q
H
QA
LL
V
F
DEV
QC
G
MG
RTG
D
LFA
YMHYGVT
PD
I
L
T
S
AK
A
L
G
GG
-
F
P
I
S
A
ML
T
T
AE
IA
S
A
FH
PG
S
--
---H
G
S
T
YG
GNPLA
C
A
V
A
G
A
A
F
DIINTPEVL
E
GIQAKRQ
R
F
V
D
H
L
QK
I
D
Q
QYDVFS
D
I
RG
M
G
fig|340184.3.peg.3495
Escherichia coli B7A (18-339/406)
LPIYA
P
A
EFI
PVK
G
Q
G
SR
I
W
D
Q
Q
G
KE
YVD
FAG
GI
AVTAL
GH
C
HP
A
L
V
N
A
L
-
K
T
Q
GETLW
H
IS-NVFTN
E
PA
L
R
L
G
R
K
L
---I
E
ATFAER
V
VFMN
SG
T
EA
N
E
T
A
F
KLAR
HYACVRHSP
FK
TKI
I
A
F
H
N
A
F
HG
R
S
--------
LF
T
V
S
V
GGQ-PK
-
YSDGF
G
PK
P
A
D
IIHVPF-NDLHAVKA-------------
-
VMDDHT
C
A
VV
A
EP
I
-
QG
E
GG
VTAAT
PE
F
L
QG
LR
E
LCD
Q
H
QA
LL
V
F
DEV
QC
G
MG
RTG
D
LFA
YMHYGVT
PD
I
L
T
S
AK
A
L
G
GG
-
F
P
I
S
A
ML
T
T
AE
IA
S
A
FH
PG
S
--
---H
G
S
T
YG
GNPL
S
C
A
V
A
G
A
A
F
DIINTPEVL
E
GIQAKRQ
R
F
V
D
H
L
QK
I
D
Q
QYDVFS
D
I
RG
M
G
fig|340184.6.peg.3657
Escherichia coli B7A (18-339/406)
LPIYA
P
A
EFI
PVK
G
Q
G
SR
I
W
D
Q
Q
G
KE
YVD
FAG
GI
AVTAL
GH
C
HP
A
L
V
N
A
L
-
K
T
Q
GETLW
H
IS-NVFTN
E
PA
L
R
L
G
R
K
L
---I
E
ATFAER
V
VFMN
SG
T
EA
N
E
T
A
F
KLAR
HYACVRHSP
FK
TKI
I
A
F
H
N
A
F
HG
R
S
--------
LF
T
V
S
V
GGQ-PK
-
YSDGF
G
PK
P
A
D
IIHVPF-NDLHAVKA-------------
-
VMDDHT
C
A
VV
A
EP
I
-
QG
E
GG
VTAAT
PE
F
L
QG
LR
E
LCD
Q
H
QA
LL
V
F
DEV
QC
G
MG
RTG
D
LFA
YMHYGVT
PD
I
L
T
S
AK
A
L
G
GG
-
F
P
I
S
A
ML
T
T
AE
IA
S
A
FH
PG
S
--
---H
G
S
T
YG
GNPL
S
C
A
V
A
G
A
A
F
DIINTPEVL
E
GIQAKRQ
R
F
V
D
H
L
QK
I
D
Q
QYDVFS
D
I
RG
M
G
fig|749537.3.peg.2956
Escherichia coli MS 115-1 (18-339/406)
LPIYA
P
A
EFI
PVK
G
Q
G
SR
I
W
D
Q
Q
G
KE
YVD
FAG
GI
AVTAL
GH
C
H
S
A
L
V
N
A
L
-
K
T
Q
GETLW
H
IS-NVFTN
E
PA
L
R
L
G
R
K
L
---I
E
ATFAER
V
VFMN
SG
T
EA
N
E
T
A
F
KLAR
HYACVRHSP
FK
TKI
I
A
F
H
N
A
F
HG
R
S
--------
LF
T
V
S
V
GGQ-PK
-
YSDGF
G
PK
P
A
D
IIHVPF-NDLHAVKA-------------
-
VMDDHT
C
A
VV
V
EP
I
-
QG
E
GG
VTAAT
PE
F
L
QG
LR
E
LCD
Q
H
QA
LL
V
F
DEV
QC
G
MG
RTG
D
LFA
YMHYGVT
PD
I
L
T
S
AK
A
L
G
GG
-
F
P
I
S
A
ML
T
T
AE
IA
S
A
FH
PG
S
--
---H
G
S
T
YG
GNPLA
C
A
V
A
G
A
A
F
DIINTPEVL
E
GIQAKRQ
R
F
V
D
H
L
QK
I
D
Q
QYDVFS
D
I
RG
M
G
fig|670897.3.peg.3995
Escherichia coli 2362-75 (18-339/406)
LPIYA
P
A
EFI
PVK
G
Q
G
SR
I
W
D
Q
Q
G
KE
YVD
FAG
GI
AVTAL
GH
C
HP
A
L
V
N
A
L
-
K
T
Q
GETLW
H
IS-NVFTN
E
PA
L
R
L
G
R
K
L
---I
E
ATFAER
V
VFMN
SG
T
EA
N
E
T
A
F
KLAR
HYACVRHSP
FK
TKI
I
A
F
H
N
A
F
HG
R
S
--------
LF
T
V
S
V
GGQ-PK
-
YSDGF
G
PK
P
A
D
IIHVPF-NDLHAVKA-------------
-
VMDDHT
C
A
VV
V
EP
I
-
QG
E
GG
VTAAT
L
E
F
L
QG
LR
E
LCD
Q
H
QA
LL
V
F
DEV
QC
G
MG
RTG
D
LFA
YMHYGVT
PD
I
L
T
S
AK
A
L
G
GG
-
F
P
V
S
A
ML
T
A
AE
IA
S
A
FH
PG
S
--
---H
G
S
T
YG
GNPLA
C
A
V
A
G
A
A
F
DIINTPEVL
E
GIQAKRQ
H
F
V
D
H
L
QK
I
D
Q
QYDVFS
D
I
RG
M
G
fig|216593.1.peg.4082
Escherichia coli E2348/69 (18-339/406)
LPIYA
P
A
EFI
PVK
G
Q
G
SR
I
W
D
Q
Q
G
KE
YVD
FAG
GI
AVTAL
GH
C
HP
A
L
V
N
A
L
-
K
T
Q
GETLW
H
IS-NVFTN
E
PA
L
R
L
G
R
K
L
---I
E
ATFAER
V
VFMN
SG
T
EA
N
E
T
A
F
KLAR
HYACVRHSP
FK
TKI
I
A
F
H
N
A
F
HG
R
S
--------
LF
T
V
S
V
GGQ-PK
-
YSDGF
G
PK
P
A
D
IIHVPF-NDLHAVKA-------------
-
VMDDHT
C
A
VV
V
EP
I
-
QG
E
GG
VTAAT
L
E
F
L
QG
LR
E
LCD
Q
H
QA
LL
V
F
DEV
QC
G
MG
RTG
D
LFA
YMHYGVT
PD
I
L
T
S
AK
A
L
G
GG
-
F
P
V
S
A
ML
T
A
AE
IA
S
A
FH
PG
S
--
---H
G
S
T
YG
GNPLA
C
A
V
A
G
A
A
F
DIINTPEVL
E
GIQAKRQ
H
F
V
D
H
L
QK
I
D
Q
QYDVFS
D
I
RG
M
G
fig|574521.7.peg.3688
Escherichia coli O127:H6 str. E2348/69 (18-339/406)
LPIYA
P
A
EFI
PVK
G
Q
G
SR
I
W
D
Q
Q
G
KE
YVD
FAG
GI
AVTAL
GH
C
HP
A
L
V
N
A
L
-
K
T
Q
GETLW
H
IS-NVFTN
E
PA
L
R
L
G
R
K
L
---I
E
ATFAER
V
VFMN
SG
T
EA
N
E
T
A
F
KLAR
HYACVRHSP
FK
TKI
I
A
F
H
N
A
F
HG
R
S
--------
LF
T
V
S
V
GGQ-PK
-
YSDGF
G
PK
P
A
D
IIHVPF-NDLHAVKA-------------
-
VMDDHT
C
A
VV
V
EP
I
-
QG
E
GG
VTAAT
L
E
F
L
QG
LR
E
LCD
Q
H
QA
LL
V
F
DEV
QC
G
MG
RTG
D
LFA
YMHYGVT
PD
I
L
T
S
AK
A
L
G
GG
-
F
P
V
S
A
ML
T
A
AE
IA
S
A
FH
PG
S
--
---H
G
S
T
YG
GNPLA
C
A
V
A
G
A
A
F
DIINTPEVL
E
GIQAKRQ
H
F
V
D
H
L
QK
I
D
Q
QYDVFS
D
I
RG
M
G
fig|331112.3.peg.3328
Escherichia coli HS (18-339/406)
LPIYA
P
A
EFI
PVK
G
Q
G
SR
I
W
D
Q
Q
G
KE
YVD
FAG
GI
AVTAL
GH
C
HP
A
L
V
N
A
L
-
K
T
Q
GETLW
H
IS-NVFTN
E
PA
L
R
L
G
H
K
L
---I
E
ATFAER
V
VFMN
SG
T
EA
N
E
T
A
F
KLAR
HYACVRHSP
FK
TKI
I
A
F
H
K
A
F
HG
R
S
--------
LF
T
V
S
V
GGQ-PK
-
YSDGF
G
SK
P
A
D
IIHVPF-NDLHAVKA-------------
-
VMDDHT
C
A
VV
V
EP
I
-
QG
E
GG
VTAAT
PE
F
L
QG
LR
E
LCD
Q
H
QA
LL
V
F
DEV
QC
G
MG
RTG
D
LFA
YMHYGVT
PD
I
L
T
S
AK
A
L
G
GG
-
F
P
I
S
A
ML
T
T
AE
IA
S
A
FH
PG
S
--
---H
G
S
T
YG
GNPLA
C
A
V
A
G
A
A
F
DIINTPEVL
E
GIQAKRQ
R
F
V
D
H
L
QK
I
D
Q
QYDVFS
D
I
RG
M
G
fig|331112.6.peg.3461
Escherichia coli HS (18-339/406)
LPIYA
P
A
EFI
PVK
G
Q
G
SR
I
W
D
Q
Q
G
KE
YVD
FAG
GI
AVTAL
GH
C
HP
A
L
V
N
A
L
-
K
T
Q
GETLW
H
IS-NVFTN
E
PA
L
R
L
G
H
K
L
---I
E
ATFAER
V
VFMN
SG
T
EA
N
E
T
A
F
KLAR
HYACVRHSP
FK
TKI
I
A
F
H
K
A
F
HG
R
S
--------
LF
T
V
S
V
GGQ-PK
-
YSDGF
G
SK
P
A
D
IIHVPF-NDLHAVKA-------------
-
VMDDHT
C
A
VV
V
EP
I
-
QG
E
GG
VTAAT
PE
F
L
QG
LR
E
LCD
Q
H
QA
LL
V
F
DEV
QC
G
MG
RTG
D
LFA
YMHYGVT
PD
I
L
T
S
AK
A
L
G
GG
-
F
P
I
S
A
ML
T
T
AE
IA
S
A
FH
PG
S
--
---H
G
S
T
YG
GNPLA
C
A
V
A
G
A
A
F
DIINTPEVL
E
GIQAKRQ
R
F
V
D
H
L
QK
I
D
Q
QYDVFS
D
I
RG
M
G
fig|679206.4.peg.4004
Escherichia coli MS 119-7 (24-351/421)
Y
F
V
G
-
---
--K
AE
N
AT
L
W
D
V
EG
NE
V
I
D
FAA
GI
AVLNT
GH
R
HP
K
I
V
AAV
-
E
Q
Q
LQSFT
H
TAYQIVPY
E
SY
V
S
L
A
E
R
I
NAVA
P
VDGPAK
T
AFFT
T
G
A
EA
V
E
N
A
V
K
I
AR
AYTG-----
-
R
PGI
I
T
F
G
G
G
F
HG
R
T
--------
FM
TM
A
L
TGKVAP
-
YKTGF
G
PF
P
G
S
VYHAVYPNDAHGISVDDALRSLDRIFKA
D
IPADQV
AAI
V
L
EPV
-
QG
E
GG
FNVAP
A
A
F
M
QA
LR
E
LCD
T
H
GILL
V
A
DEV
QT
G
FA
RTG
R
LFA
MQHYAVK
A
DL
I
T
M
AK
S
L
A
GG
-
F
PL
S
G
VV
G
R
AEVM
D
A
PA
PG
G
--
---L
G
G
T
YA
GNPLA
V
AAA
H
A
V
L
DIIEEEQLC
Q
RADQLGE
H
L
K
E
V
L
SQ
A
R
A
GCPAIA
DVRGLG
fig|344610.3.peg.1174
Escherichia coli 53638 (28-351/421)
S
AE
N
AT
L
K
D
V
EG
NE
Y
I
D
FAA
GI
AVLNT
GH
R
HP
D
L
V
AAV
-
E
Q
Q
LQQFT
H
TAYQIVPY
E
SY
V
T
L
A
E
K
I
NALA
P
VSGQAK
T
AFFT
T
G
A
EA
V
E
N
A
V
K
M
AR
AHTG-----
-
R
PGV
I
A
F
S
G
G
F
HG
R
T
--------
YM
TM
A
L
TGKVAP
-
YKIGF
G
PF
P
G
S
VYHVPYPSDLHGISTQDSLDAIERLFKS
D
IEAKQV
AAII
F
EPV
-
QG
E
GG
FNVAP
K
E
L
V
AA
I
R
R
LCDE
H
GI
V
M
I
A
DEV
QS
G
FA
RTG
K
LFA
MDHYADK
PDL
M
T
M
AK
S
L
A
GG
-
MPL
S
G
VV
G
N
A
N
I
M
D
A
PA
PG
G
--
---L
G
G
T
YA
GNPLA
V
AAA
H
A
V
L
NIIDKESLC
E
RANQLGQ
RL
K
N
T
L
ID
A
K
E
SVPAIA
A
VRGLG
fig|344610.7.peg.4984
Escherichia coli 53638 (28-351/421)
S
AE
N
AT
L
K
D
V
EG
NE
Y
I
D
FAA
GI
AVLNT
GH
R
HP
D
L
V
AAV
-
E
Q
Q
LQQFT
H
TAYQIVPY
E
SY
V
T
L
A
E
K
I
NALA
P
VSGQAK
T
AFFT
T
G
A
EA
V
E
N
A
V
K
M
AR
AHTG-----
-
R
PGV
I
A
F
S
G
G
F
HG
R
T
--------
YM
TM
A
L
TGKVAP
-
YKIGF
G
PF
P
G
S
VYHVPYPSDLHGISTQDSLDAIERLFKS
D
IEAKQV
AAII
F
EPV
-
QG
E
GG
FNVAP
K
E
L
V
AA
I
R
R
LCDE
H
GI
V
M
I
A
DEV
QS
G
FA
RTG
K
LFA
MDHYADK
PDL
M
T
M
AK
S
L
A
GG
-
MPL
S
G
VV
G
N
A
N
I
M
D
A
PA
PG
G
--
---L
G
G
T
YA
GNPLA
V
AAA
H
A
V
L
NIIDKESLC
E
RANQLGQ
RL
K
N
T
L
ID
A
K
E
SVPAIA
A
VRGLG
fig|331112.3.peg.1327
Escherichia coli HS (28-351/421)
S
AE
N
AT
L
K
D
V
EG
NE
Y
I
D
FAA
GI
AVLNT
GH
R
HP
D
L
V
AAV
-
E
Q
Q
LQQFT
H
TAYQIVPY
E
SY
V
T
L
A
E
K
I
NALA
P
VSGQAK
T
AFFT
T
G
A
EA
V
E
N
A
V
K
M
AR
AHTG-----
-
R
PGV
I
A
F
S
G
G
F
HG
R
T
--------
YM
TM
A
L
TGKVAP
-
YKIGF
G
PF
P
G
S
VYHVPYPSDLHGISTQDSLDAIERLFKS
D
IEAKQV
AAII
F
EPV
-
QG
E
GG
FNVAP
K
E
L
V
AA
I
R
R
LCDE
H
GI
V
M
I
A
DEV
QS
G
FA
RTG
K
LFA
MDHYADK
PDL
M
T
M
AK
S
L
A
GG
-
MPL
S
G
VV
G
N
A
N
I
M
D
A
PA
PG
G
--
---L
G
G
T
YA
GNPLA
V
AAA
H
A
V
L
NIIDKESLC
K
RANQLGQ
RL
K
N
T
L
ID
A
K
E
SVPAIA
A
VRGLG
fig|331112.6.peg.1381
Escherichia coli HS (28-351/421)
S
AE
N
AT
L
K
D
V
EG
NE
Y
I
D
FAA
GI
AVLNT
GH
R
HP
D
L
V
AAV
-
E
Q
Q
LQQFT
H
TAYQIVPY
E
SY
V
T
L
A
E
K
I
NALA
P
VSGQAK
T
AFFT
T
G
A
EA
V
E
N
A
V
K
M
AR
AHTG-----
-
R
PGV
I
A
F
S
G
G
F
HG
R
T
--------
YM
TM
A
L
TGKVAP
-
YKIGF
G
PF
P
G
S
VYHVPYPSDLHGISTQDSLDAIERLFKS
D
IEAKQV
AAII
F
EPV
-
QG
E
GG
FNVAP
K
E
L
V
AA
I
R
R
LCDE
H
GI
V
M
I
A
DEV
QS
G
FA
RTG
K
LFA
MDHYADK
PDL
M
T
M
AK
S
L
A
GG
-
MPL
S
G
VV
G
N
A
N
I
M
D
A
PA
PG
G
--
---L
G
G
T
YA
GNPLA
V
AAA
H
A
V
L
NIIDKESLC
K
RANQLGQ
RL
K
N
T
L
ID
A
K
E
SVPAIA
A
VRGLG
fig|585395.4.peg.1538
Escherichia coli O103:H2 str. 12009 (28-351/421)
S
AE
N
AT
L
K
D
V
EG
NE
Y
I
D
FAA
GI
AVLNT
GH
R
HP
D
L
V
AAV
-
E
Q
Q
LQQFT
H
TAYQIVPY
E
SY
V
T
L
A
E
K
I
NALA
P
VSGQAK
T
AFFT
T
G
A
EA
V
E
N
A
V
K
I
AR
AHTG-----
-
R
PSV
I
A
F
S
G
G
F
HG
R
T
--------
YM
TM
A
L
TGKVAP
-
YKIGF
G
PF
P
G
S
VYHVPYPSDLHGISTQDSLDAIERLFKS
D
IEAKQV
AAII
F
EPV
-
QG
E
GG
FNVAP
K
E
L
V
AA
I
R
R
LCDE
H
GI
V
M
I
A
DEV
QS
G
FA
RTG
K
LFA
MDHYADK
PDL
M
T
M
AK
S
L
A
GG
-
MPL
S
G
VV
G
N
A
N
I
M
D
A
PA
PG
G
--
---L
G
G
T
YA
GNPLA
V
AAA
H
A
V
L
NIIDKESLC
E
RANQLGQ
RL
K
N
T
L
ID
A
K
E
SVPAIA
A
VRGLG
fig|585034.4.peg.1316
Escherichia coli IAI1 (28-351/421)
S
AE
N
AT
L
K
D
V
EG
NE
Y
I
D
FAA
GI
AVLNT
GH
R
HP
E
L
V
AAV
-
E
Q
Q
LQQFT
H
TAYQIVPY
E
SY
V
T
L
A
E
K
I
NALA
P
VSGQAK
T
AFFT
T
G
A
EA
V
E
N
A
V
K
I
AR
AHTG-----
-
R
PGV
I
A
F
S
G
G
F
HG
R
T
--------
YM
TM
A
L
TGKVAP
-
YKIGF
G
PF
P
G
S
VYHVPYPSDLHGISTQDSLDAIERLFKS
D
IEAKQV
AAII
F
EPV
-
QG
E
GG
FNVAP
K
E
L
V
AA
I
R
R
LCDE
H
GI
V
M
I
A
DEV
QS
G
FA
RTG
K
LFA
MDHYVDK
PDL
M
T
M
AK
S
L
A
GG
-
MPL
S
G
VV
G
N
A
N
I
M
D
A
PA
PG
G
--
---L
G
G
T
YA
GNPLA
V
AAA
H
A
V
L
NIIDKESLC
E
RANQLGQ
RL
K
N
T
L
ID
A
K
E
SVPAIA
A
VRGLG
fig|585034.5.peg.1312
Escherichia coli IAI1 (28-351/421)
S
AE
N
AT
L
K
D
V
EG
NE
Y
I
D
FAA
GI
AVLNT
GH
R
HP
E
L
V
AAV
-
E
Q
Q
LQQFT
H
TAYQIVPY
E
SY
V
T
L
A
E
K
I
NALA
P
VSGQAK
T
AFFT
T
G
A
EA
V
E
N
A
V
K
I
AR
AHTG-----
-
R
PGV
I
A
F
S
G
G
F
HG
R
T
--------
YM
TM
A
L
TGKVAP
-
YKIGF
G
PF
P
G
S
VYHVPYPSDLHGISTQDSLDAIERLFKS
D
IEAKQV
AAII
F
EPV
-
QG
E
GG
FNVAP
K
E
L
V
AA
I
R
R
LCDE
H
GI
V
M
I
A
DEV
QS
G
FA
RTG
K
LFA
MDHYVDK
PDL
M
T
M
AK
S
L
A
GG
-
MPL
S
G
VV
G
N
A
N
I
M
D
A
PA
PG
G
--
---L
G
G
T
YA
GNPLA
V
AAA
H
A
V
L
NIIDKESLC
E
RANQLGQ
RL
K
N
T
L
ID
A
K
E
SVPAIA
A
VRGLG
fig|1040638.4.peg.4064
Escherichia coli O104:H4 str. LB226692 (28-351/421)
S
AE
N
AT
L
K
D
V
EG
NE
Y
I
D
FAA
GI
AVLNT
GH
R
HP
E
L
V
AAV
-
E
Q
Q
LQQFT
H
TAYQIVPY
E
SY
V
T
L
A
E
K
I
NALA
P
VSGQAK
T
AFFT
T
G
A
EA
V
E
N
A
V
K
I
AR
AHTG-----
-
R
PGV
I
A
F
S
G
G
F
HG
R
T
--------
YM
TM
A
L
TGKVAP
-
YKIGF
G
PF
P
G
S
VYHVPYPSDLHGISTQDSLDAIERLFKS
D
IEAKQV
AAII
F
EPV
-
QG
E
GG
FNVAP
K
E
L
V
AA
I
R
R
LCDE
H
GI
V
M
I
A
DEV
QS
G
FA
RTG
K
LFA
MDHYVDK
PDL
M
T
M
AK
S
L
A
GG
-
MPL
S
G
VV
G
N
A
N
I
M
D
A
PA
PG
G
--
---L
G
G
T
YA
GNPLA
V
AAA
H
A
V
L
NIIDKESLC
E
RANQLGQ
RL
K
N
T
L
ID
A
K
E
SVPAIA
A
VRGLG
fig|6666666.5357.peg.3274
Escherichia coli TY-2482 (28-351/421)
S
AE
N
AT
L
K
D
V
EG
NE
Y
I
D
FAA
GI
AVLNT
GH
R
HP
E
L
V
AAV
-
E
Q
Q
LQQFT
H
TAYQIVPY
E
SY
V
T
L
A
E
K
I
NALA
P
VSGQAK
T
AFFT
T
G
A
EA
V
E
N
A
V
K
I
AR
AHTG-----
-
R
PGV
I
A
F
S
G
G
F
HG
R
T
--------
YM
TM
A
L
TGKVAP
-
YKIGF
G
PF
P
G
S
VYHVPYPSDLHGISTQDSLDAIERLFKS
D
IEAKQV
AAII
F
EPV
-
QG
E
GG
FNVAP
K
E
L
V
AA
I
R
R
LCDE
H
GI
V
M
I
A
DEV
QS
G
FA
RTG
K
LFA
MDHYVDK
PDL
M
T
M
AK
S
L
A
GG
-
MPL
S
G
VV
G
N
A
N
I
M
D
A
PA
PG
G
--
---L
G
G
T
YA
GNPLA
V
AAA
H
A
V
L
NIIDKESLC
E
RANQLGQ
RL
K
N
T
L
ID
A
K
E
SVPAIA
A
VRGLG
fig|340186.3.peg.330
Escherichia coli E110019 (28-351/421)
S
AE
N
AT
L
K
D
V
EG
NE
Y
I
D
FAA
GI
AVLNT
GH
R
HP
D
L
V
AAV
-
E
Q
Q
LQQFT
H
TAYQIVPY
E
SY
V
T
L
A
E
K
I
NALA
P
VSGQAK
T
AFFT
T
G
A
EA
V
E
N
A
V
K
I
AR
AHTG-----
-
R
PGV
I
A
F
S
G
G
F
HG
R
T
--------
YM
TM
A
L
TGKVAP
-
YKIGF
G
PF
P
G
S
VYHVPYPSDLHGISTQDSLDAIERLFKS
D
IEAKQV
AAII
F
EPV
-
QG
E
GG
FNVAP
K
E
L
V
AA
I
R
R
LCDE
H
GI
V
M
I
A
DEV
QS
G
FA
RTG
K
LFA
MDHYADK
PDL
M
T
M
AK
S
L
A
GG
-
MPL
S
G
VV
G
N
A
N
I
M
D
A
PA
PG
G
--
---L
G
G
T
YA
GNPLA
V
AAA
H
A
V
L
NIIDKESLC
E
RANQLGQ
RL
K
N
T
L
ID
A
K
E
SVPAIA
A
VRGLG
fig|340186.5.peg.349
Escherichia coli E110019 (28-351/421)
S
AE
N
AT
L
K
D
V
EG
NE
Y
I
D
FAA
GI
AVLNT
GH
R
HP
D
L
V
AAV
-
E
Q
Q
LQQFT
H
TAYQIVPY
E
SY
V
T
L
A
E
K
I
NALA
P
VSGQAK
T
AFFT
T
G
A
EA
V
E
N
A
V
K
I
AR
AHTG-----
-
R
PGV
I
A
F
S
G
G
F
HG
R
T
--------
YM
TM
A
L
TGKVAP
-
YKIGF
G
PF
P
G
S
VYHVPYPSDLHGISTQDSLDAIERLFKS
D
IEAKQV
AAII
F
EPV
-
QG
E
GG
FNVAP
K
E
L
V
AA
I
R
R
LCDE
H
GI
V
M
I
A
DEV
QS
G
FA
RTG
K
LFA
MDHYADK
PDL
M
T
M
AK
S
L
A
GG
-
MPL
S
G
VV
G
N
A
N
I
M
D
A
PA
PG
G
--
---L
G
G
T
YA
GNPLA
V
AAA
H
A
V
L
NIIDKESLC
E
RANQLGQ
RL
K
N
T
L
ID
A
K
E
SVPAIA
A
VRGLG
fig|679207.4.peg.3922
Escherichia coli MS 107-1 (28-351/421)
S
AE
N
AT
L
K
D
V
EG
NE
Y
I
D
FAA
GI
AVLNT
GH
R
HP
D
L
V
AAV
-
E
Q
Q
LQQFT
H
TAYQIVPY
E
SY
V
T
L
A
E
K
I
NALA
P
VSGQAK
T
AFFT
T
G
A
EA
V
E
N
A
V
K
I
AR
AHTG-----
-
R
PGV
I
A
F
S
G
G
F
HG
R
T
--------
YM
TM
A
L
TGKVAP
-
YKIGF
G
PF
P
G
S
VYHVPYPSDLHGISTQDSLDAIERLFKS
D
IEAKQV
AAII
F
EPV
-
QG
E
GG
FNVAP
K
E
L
V
AA
I
R
R
LCDE
H
GI
V
M
I
A
DEV
QS
G
FA
RTG
K
LFA
MDHYADK
PDL
M
T
M
AK
S
L
A
GG
-
MPL
S
G
VV
G
N
A
N
I
M
D
A
PA
PG
G
--
---L
G
G
T
YA
GNPLA
V
AAA
H
A
V
L
NIIDKESLC
E
RANQLGQ
RL
K
N
T
L
ID
A
K
E
SVPAIA
A
VRGLG
fig|679206.4.peg.2304
Escherichia coli MS 119-7 (28-351/421)
S
AE
N
AT
L
K
D
V
EG
NE
Y
I
D
FAA
GI
AVLNT
GH
R
HP
D
L
V
AAV
-
E
Q
Q
LQQFT
H
TAYQIVPY
E
SY
V
T
L
A
E
K
I
NALA
P
VSGQAK
T
AFFT
T
G
A
EA
V
E
N
A
V
K
I
AR
AHTG-----
-
R
PGV
I
A
F
S
G
G
F
HG
R
T
--------
YM
TM
A
L
TGKVAP
-
YKIGF
G
PF
P
G
S
VYHVPYPSDLHGISTQDSLDAIERLFKS
D
IEAKQV
AAII
F
EPV
-
QG
E
GG
FNVAP
K
E
L
V
AA
I
R
R
LCDE
H
GI
V
M
I
A
DEV
QS
G
FA
RTG
K
LFA
MDHYADK
PDL
M
T
M
AK
S
L
A
GG
-
MPL
S
G
VV
G
N
A
N
I
M
D
A
PA
PG
G
--
---L
G
G
T
YA
GNPLA
V
AAA
H
A
V
L
NIIDKESLC
E
RANQLGQ
RL
K
N
T
L
ID
A
K
E
SVPAIA
A
VRGLG
fig|749545.3.peg.4459
Escherichia coli MS 182-1 (28-351/421)
S
AE
N
AT
L
K
D
V
EG
NE
Y
I
D
FAA
GI
AVLNT
GH
R
HP
D
L
V
AAV
-
E
Q
Q
LQQFT
H
TAYQIVPY
E
SY
V
T
L
A
E
K
I
NALA
P
VSGQAK
T
AFFT
T
G
A
EA
V
E
N
A
V
K
I
AR
AHTG-----
-
R
PGV
I
A
F
S
G
G
F
HG
R
T
--------
YM
TM
A
L
TGKVAP
-
YKIGF
G
PF
P
G
S
VYHVPYPSDLHGISTQDSLDAIERLFKS
D
IEAKQV
AAII
F
EPV
-
QG
E
GG
FNVAP
K
E
L
V
AA
I
R
R
LCDE
H
GI
V
M
I
A
DEV
QS
G
FA
RTG
K
LFA
MDHYADK
PDL
M
T
M
AK
S
L
A
GG
-
MPL
S
G
VV
G
N
A
N
I
M
D
A
PA
PG
G
--
---L
G
G
T
YA
GNPLA
V
AAA
H
A
V
L
NIIDKESLC
E
RANQLGQ
RL
K
N
T
L
ID
A
K
E
SVPAIA
A
VRGLG
fig|749532.3.peg.1791
Escherichia coli MS 78-1 (28-351/421)
S
AE
N
AT
L
K
D
V
EG
NE
Y
I
D
FAA
GI
AVLNT
GH
R
HP
D
L
V
AAV
-
E
Q
Q
LQQFT
H
TAYQIVPY
E
SY
V
T
L
A
E
K
I
NALA
P
VSGQAK
T
AFFT
T
G
A
EA
V
E
N
A
V
K
I
AR
AHTG-----
-
R
PGV
I
A
F
S
G
G
F
HG
R
T
--------
YM
TM
A
L
TGKVAP
-
YKIGF
G
PF
P
G
S
VYHVPYPSDLHGISTQDSLDAIERLFKS
D
IEAKQV
AAII
F
EPV
-
QG
E
GG
FNVAP
K
E
L
V
AA
I
R
R
LCDE
H
GI
V
M
I
A
DEV
QS
G
FA
RTG
K
LFA
MDHYADK
PDL
M
T
M
AK
S
L
A
GG
-
MPL
S
G
VV
G
N
A
N
I
M
D
A
PA
PG
G
--
---L
G
G
T
YA
GNPLA
V
AAA
H
A
V
L
NIIDKESLC
E
RANQLGQ
RL
K
N
T
L
ID
A
K
E
SVPAIA
A
VRGLG
fig|573235.3.peg.1900
Escherichia coli O26:H11 str. 11368 (28-351/421)
S
AE
N
AT
L
K
D
V
EG
NE
Y
I
D
FAA
GI
AVLNT
GH
R
HP
D
L
V
AAV
-
E
Q
Q
LQQFT
H
TAYQIVPY
E
SY
V
T
L
A
E
K
I
NALA
P
VSGQAK
T
AFFT
T
G
A
EA
V
E
N
A
V
K
I
AR
AHTG-----
-
R
PGV
I
A
F
S
G
G
F
HG
R
T
--------
YM
TM
A
L
TGKVAP
-
YKIGF
G
PF
P
G
S
VYHVPYPSDLHGISTQDSLDAIERLFKS
D
IEAKQV
AAII
F
EPV
-
QG
E
GG
FNVAP
K
E
L
V
AA
I
R
R
LCDE
H
GI
V
M
I
A
DEV
QS
G
FA
RTG
K
LFA
MDHYADK
PDL
M
T
M
AK
S
L
A
GG
-
MPL
S
G
VV
G
N
A
N
I
M
D
A
PA
PG
G
--
---L
G
G
T
YA
GNPLA
V
AAA
H
A
V
L
NIIDKESLC
E
RANQLGQ
RL
K
N
T
L
ID
A
K
E
SVPAIA
A
VRGLG
fig|656443.3.peg.1639
Escherichia coli TA271 (28-351/421)
S
AE
N
AT
L
K
D
V
EG
NE
Y
I
D
FAA
GI
AVLNT
GH
R
HP
D
L
V
AAV
-
E
Q
Q
LQQFT
H
TAYQIVPY
E
SY
V
T
L
A
E
K
I
NALA
P
VSGQAK
T
AFFT
T
G
A
EA
V
E
N
A
V
K
I
AR
AHTG-----
-
R
PGV
I
A
F
S
G
G
F
HG
R
T
--------
YM
TM
A
L
TGKVAP
-
YKIGF
G
PF
P
G
S
VYHVPYPSDLHGISTQDSLDAIERLFKS
D
IEAKQV
AAII
F
EPV
-
QG
E
GG
FNVAP
K
E
L
V
AA
I
R
R
LCDE
H
GI
V
M
I
A
DEV
QS
G
FA
RTG
K
LFA
MDHYADK
PDL
M
T
M
AK
S
L
A
GG
-
MPL
S
G
VV
G
N
A
N
I
M
D
A
PA
PG
G
--
---L
G
G
T
YA
GNPLA
V
AAA
H
A
V
L
NIIDKESLC
E
RANQLGQ
RL
K
N
T
L
ID
A
K
E
SVPAIA
A
VRGLG
fig|585396.4.peg.1753
Escherichia coli O111:H- str. 11128 (28-351/421)
S
AE
N
AT
L
K
D
V
EG
NE
Y
I
D
FAA
GI
AVLNT
GH
R
HP
D
L
V
AAV
-
E
Q
Q
LQQFT
H
TAYQIVPY
E
SY
V
T
L
A
E
K
I
NALA
P
VSGQAK
T
AFFT
T
G
A
EA
V
E
N
A
V
K
I
AR
AHTG-----
-
R
PGV
I
A
F
S
G
G
F
HG
R
T
--------
YM
TM
A
L
TGKVAP
-
YKIGF
G
PF
P
G
S
VYHVPYPSDLHGISTQDSLDAIERLFKS
D
IEAKQV
AAII
F
EPV
-
QG
E
GG
FNVAP
K
E
L
V
AA
I
R
R
LCDE
H
GI
V
M
I
A
DEV
QS
G
FA
RTG
K
LFA
MDHYADK
PDL
M
T
M
AK
S
L
A
GG
-
MPL
S
G
VV
G
N
A
N
I
M
D
A
PA
PG
G
--
---L
G
G
T
YA
GNPLA
V
AAA
H
A
V
L
NIIDKESLC
E
RANQLGQ
RL
K
N
T
L
ID
A
K
E
SVPAIA
A
VRGLG
fig|358709.5.peg.1635
Escherichia coli 101-1 (28-351/421)
S
AE
N
AT
L
K
D
V
EG
NE
Y
I
D
FAA
GI
AVLNT
GH
R
HP
D
L
V
AAV
-
E
Q
Q
LQQFT
H
TAYQIVPY
E
SY
V
T
L
A
E
K
I
NALA
P
VSGQAK
T
AFFT
T
G
A
EA
V
E
N
A
V
K
I
AR
AHTG-----
-
R
PGV
I
A
F
S
G
G
F
HG
R
T
--------
YM
TM
A
L
TGKVAP
-
YKIGF
G
PF
P
G
S
VYHVPYPSDLHGISTQDSLDAIERLFKS
D
IEAKQV
AAII
F
EPV
-
QG
E
GG
FNVAP
K
E
L
V
AA
I
R
R
LCDE
H
GI
V
M
I
A
DEV
QS
G
FA
RTG
K
LFA
MDHYADK
PDL
M
T
M
AK
S
L
A
GG
-
MPL
S
G
VV
G
N
A
N
I
M
D
A
PA
PG
G
--
---L
G
G
T
YA
GNPLA
V
AAA
H
A
V
L
NIIDKESLC
E
RANQLGQ
RL
K
N
T
L
ID
A
K
E
SVPAIA
A
VRGLG
fig|670888.3.peg.1993
Escherichia coli 1827-70 (28-351/421)
S
AE
N
AT
L
K
D
V
EG
NE
Y
I
D
FAA
GI
AVLNT
GH
R
HP
D
L
V
AAV
-
E
Q
Q
LQQFT
H
TAYQIVPY
E
SY
V
T
L
A
E
K
I
NALA
P
VSGQAK
T
AFFT
T
G
A
EA
V
E
N
A
V
K
I
AR
AHTG-----
-
R
PGV
I
A
F
S
G
G
F
HG
R
T
--------
YM
TM
A
L
TGKVAP
-
YKIGF
G
PF
P
G
S
VYHVPYPSDLHGISTQDSLDAIERLFKS
D
IEAKQV
AAII
F
EPV
-
QG
E
GG
FNVAP
K
E
L
V
AA
I
R
R
LCDE
H
GI
V
M
I
A
DEV
QS
G
FA
RTG
K
LFA
MDHYADK
PDL
M
T
M
AK
S
L
A
GG
-
MPL
S
G
VV
G
N
A
N
I
M
D
A
PA
PG
G
--
---L
G
G
T
YA
GNPLA
V
AAA
H
A
V
L
NIIDKESLC
E
RANQLGQ
RL
K
N
T
L
ID
A
K
E
SVPAIA
A
VRGLG
fig|481805.3.peg.2491
Escherichia coli ATCC 8739 (28-351/421)
S
AE
N
AT
L
K
D
V
EG
NE
Y
I
D
FAA
GI
AVLNT
GH
R
HP
D
L
V
AAV
-
E
Q
Q
LQQFT
H
TAYQIVPY
E
SY
V
T
L
A
E
K
I
NALA
P
VSGQAK
T
AFFT
T
G
A
EA
V
E
N
A
V
K
I
AR
AHTG-----
-
R
PGV
I
A
F
S
G
G
F
HG
R
T
--------
YM
TM
A
L
TGKVAP
-
YKIGF
G
PF
P
G
S
VYHVPYPSDLHGISTQDSLDAIERLFKS
D
IEAKQV
AAII
F
EPV
-
QG
E
GG
FNVAP
K
E
L
V
AA
I
R
R
LCDE
H
GI
V
M
I
A
DEV
QS
G
FA
RTG
K
LFA
MDHYADK
PDL
M
T
M
AK
S
L
A
GG
-
MPL
S
G
VV
G
N
A
N
I
M
D
A
PA
PG
G
--
---L
G
G
T
YA
GNPLA
V
AAA
H
A
V
L
NIIDKESLC
E
RANQLGQ
RL
K
N
T
L
ID
A
K
E
SVPAIA
A
VRGLG
fig|481805.6.peg.2481
Escherichia coli ATCC 8739 (28-351/421)
S
AE
N
AT
L
K
D
V
EG
NE
Y
I
D
FAA
GI
AVLNT
GH
R
HP
D
L
V
AAV
-
E
Q
Q
LQQFT
H
TAYQIVPY
E
SY
V
T
L
A
E
K
I
NALA
P
VSGQAK
T
AFFT
T
G
A
EA
V
E
N
A
V
K
I
AR
AHTG-----
-
R
PGV
I
A
F
S
G
G
F
HG
R
T
--------
YM
TM
A
L
TGKVAP
-
YKIGF
G
PF
P
G
S
VYHVPYPSDLHGISTQDSLDAIERLFKS
D
IEAKQV
AAII
F
EPV
-
QG
E
GG
FNVAP
K
E
L
V
AA
I
R
R
LCDE
H
GI
V
M
I
A
DEV
QS
G
FA
RTG
K
LFA
MDHYADK
PDL
M
T
M
AK
S
L
A
GG
-
MPL
S
G
VV
G
N
A
N
I
M
D
A
PA
PG
G
--
---L
G
G
T
YA
GNPLA
V
AAA
H
A
V
L
NIIDKESLC
E
RANQLGQ
RL
K
N
T
L
ID
A
K
E
SVPAIA
A
VRGLG
fig|413997.3.peg.1349
Escherichia coli B str. REL606 (28-351/421)
S
AE
N
AT
L
K
D
V
EG
NE
Y
I
D
FAA
GI
AVLNT
GH
R
HP
D
L
V
AAV
-
E
Q
Q
LQQFT
H
TAYQIVPY
E
SY
V
T
L
A
E
K
I
NALA
P
VSGQAK
T
AFFT
T
G
A
EA
V
E
N
A
V
K
I
AR
AHTG-----
-
R
PGV
I
A
F
S
G
G
F
HG
R
T
--------
YM
TM
A
L
TGKVAP
-
YKIGF
G
PF
P
G
S
VYHVPYPSDLHGISTQDSLDAIERLFKS
D
IEAKQV
AAII
F
EPV
-
QG
E
GG
FNVAP
K
E
L
V
AA
I
R
R
LCDE
H
GI
V
M
I
A
DEV
QS
G
FA
RTG
K
LFA
MDHYADK
PDL
M
T
M
AK
S
L
A
GG
-
MPL
S
G
VV
G
N
A
N
I
M
D
A
PA
PG
G
--
---L
G
G
T
YA
GNPLA
V
AAA
H
A
V
L
NIIDKESLC
E
RANQLGQ
RL
K
N
T
L
ID
A
K
E
SVPAIA
A
VRGLG
fig|550672.3.peg.787
Escherichia coli B088 (28-351/421)
S
AE
N
AT
L
K
D
V
EG
NE
Y
I
D
FAA
GI
AVLNT
GH
R
HP
D
L
V
AAV
-
E
Q
Q
LQQFT
H
TAYQIVPY
E
SY
V
T
L
A
E
K
I
NALA
P
VSGQAK
T
AFFT
T
G
A
EA
V
E
N
A
V
K
I
AR
AHTG-----
-
R
PGV
I
A
F
S
G
G
F
HG
R
T
--------
YM
TM
A
L
TGKVAP
-
YKIGF
G
PF
P
G
S
VYHVPYPSDLHGISTQDSLDAIERLFKS
D
IEAKQV
AAII
F
EPV
-
QG
E
GG
FNVAP
K
E
L
V
AA
I
R
R
LCDE
H
GI
V
M
I
A
DEV
QS
G
FA
RTG
K
LFA
MDHYADK
PDL
M
T
M
AK
S
L
A
GG
-
MPL
S
G
VV
G
N
A
N
I
M
D
A
PA
PG
G
--
---L
G
G
T
YA
GNPLA
V
AAA
H
A
V
L
NIIDKESLC
E
RANQLGQ
RL
K
N
T
L
ID
A
K
E
SVPAIA
A
VRGLG
fig|344601.3.peg.134
Escherichia coli B171 (28-351/421)
S
AE
N
AT
L
K
D
V
EG
NE
Y
I
D
FAA
GI
AVLNT
GH
R
HP
D
L
V
AAV
-
E
Q
Q
LQQFT
H
TAYQIVPY
E
SY
V
T
L
A
E
K
I
NALA
P
VSGQAK
T
AFFT
T
G
A
EA
V
E
N
A
V
K
I
AR
AHTG-----
-
R
PGV
I
A
F
S
G
G
F
HG
R
T
--------
YM
TM
A
L
TGKVAP
-
YKIGF
G
PF
P
G
S
VYHVPYPSDLHGISTQDSLDAIERLFKS
D
IEAKQV
AAII
F
EPV
-
QG
E
GG
FNVAP
K
E
L
V
AA
I
R
R
LCDE
H
GI
V
M
I
A
DEV
QS
G
FA
RTG
K
LFA
MDHYADK
PDL
M
T
M
AK
S
L
A
GG
-
MPL
S
G
VV
G
N
A
N
I
M
D
A
PA
PG
G
--
---L
G
G
T
YA
GNPLA
V
AAA
H
A
V
L
NIIDKESLC
E
RANQLGQ
RL
K
N
T
L
ID
A
K
E
SVPAIA
A
VRGLG
fig|344601.5.peg.130
Escherichia coli B171 (28-351/421)
S
AE
N
AT
L
K
D
V
EG
NE
Y
I
D
FAA
GI
AVLNT
GH
R
HP
D
L
V
AAV
-
E
Q
Q
LQQFT
H
TAYQIVPY
E
SY
V
T
L
A
E
K
I
NALA
P
VSGQAK
T
AFFT
T
G
A
EA
V
E
N
A
V
K
I
AR
AHTG-----
-
R
PGV
I
A
F
S
G
G
F
HG
R
T
--------
YM
TM
A
L
TGKVAP
-
YKIGF
G
PF
P
G
S
VYHVPYPSDLHGISTQDSLDAIERLFKS
D
IEAKQV
AAII
F
EPV
-
QG
E
GG
FNVAP
K
E
L
V
AA
I
R
R
LCDE
H
GI
V
M
I
A
DEV
QS
G
FA
RTG
K
LFA
MDHYADK
PDL
M
T
M
AK
S
L
A
GG
-
MPL
S
G
VV
G
N
A
N
I
M
D
A
PA
PG
G
--
---L
G
G
T
YA
GNPLA
V
AAA
H
A
V
L
NIIDKESLC
E
RANQLGQ
RL
K
N
T
L
ID
A
K
E
SVPAIA
A
VRGLG
fig|511693.5.peg.1383
Escherichia coli BL21 (28-351/421)
S
AE
N
AT
L
K
D
V
EG
NE
Y
I
D
FAA
GI
AVLNT
GH
R
HP
D
L
V
AAV
-
E
Q
Q
LQQFT
H
TAYQIVPY
E
SY
V
T
L
A
E
K
I
NALA
P
VSGQAK
T
AFFT
T
G
A
EA
V
E
N
A
V
K
I
AR
AHTG-----
-
R
PGV
I
A
F
S
G
G
F
HG
R
T
--------
YM
TM
A
L
TGKVAP
-
YKIGF
G
PF
P
G
S
VYHVPYPSDLHGISTQDSLDAIERLFKS
D
IEAKQV
AAII
F
EPV
-
QG
E
GG
FNVAP
K
E
L
V
AA
I
R
R
LCDE
H
GI
V
M
I
A
DEV
QS
G
FA
RTG
K
LFA
MDHYADK
PDL
M
T
M
AK
S
L
A
GG
-
MPL
S
G
VV
G
N
A
N
I
M
D
A
PA
PG
G
--
---L
G
G
T
YA
GNPLA
V
AAA
H
A
V
L
NIIDKESLC
E
RANQLGQ
RL
K
N
T
L
ID
A
K
E
SVPAIA
A
VRGLG
fig|469008.4.peg.2387
Escherichia coli BL21(DE3) (28-351/421)
S
AE
N
AT
L
K
D
V
EG
NE
Y
I
D
FAA
GI
AVLNT
GH
R
HP
D
L
V
AAV
-
E
Q
Q
LQQFT
H
TAYQIVPY
E
SY
V
T
L
A
E
K
I
NALA
P
VSGQAK
T
AFFT
T
G
A
EA
V
E
N
A
V
K
I
AR
AHTG-----
-
R
PGV
I
A
F
S
G
G
F
HG
R
T
--------
YM
TM
A
L
TGKVAP
-
YKIGF
G
PF
P
G
S
VYHVPYPSDLHGISTQDSLDAIERLFKS
D
IEAKQV
AAII
F
EPV
-
QG
E
GG
FNVAP
K
E
L
V
AA
I
R
R
LCDE
H
GI
V
M
I
A
DEV
QS
G
FA
RTG
K
LFA
MDHYADK
PDL
M
T
M
AK
S
L
A
GG
-
MPL
S
G
VV
G
N
A
N
I
M
D
A
PA
PG
G
--
---L
G
G
T
YA
GNPLA
V
AAA
H
A
V
L
NIIDKESLC
E
RANQLGQ
RL
K
N
T
L
ID
A
K
E
SVPAIA
A
VRGLG
fig|595496.3.peg.1243
Escherichia coli BW2952 (28-351/421)
S
AE
N
AT
L
K
D
V
EG
NE
Y
I
D
FAA
GI
AVLNT
GH
R
HP
D
L
V
AAV
-
E
Q
Q
LQQFT
H
TAYQIVPY
E
SY
V
T
L
A
E
K
I
NALA
P
VSGQAK
T
AFFT
T
G
A
EA
V
E
N
A
V
K
I
AR
AHTG-----
-
R
PGV
I
A
F
S
G
G
F
HG
R
T
--------
YM
TM
A
L
TGKVAP
-
YKIGF
G
PF
P
G
S
VYHVPYPSDLHGISTQDSLDAIERLFKS
D
IEAKQV
AAII
F
EPV
-
QG
E
GG
FNVAP
K
E
L
V
AA
I
R
R
LCDE
H
GI
V
M
I
A
DEV
QS
G
FA
RTG
K
LFA
MDHYADK
PDL
M
T
M
AK
S
L
A
GG
-
MPL
S
G
VV
G
N
A
N
I
M
D
A
PA
PG
G
--
---L
G
G
T
YA
GNPLA
V
AAA
H
A
V
L
NIIDKESLC
E
RANQLGQ
RL
K
N
T
L
ID
A
K
E
SVPAIA
A
VRGLG
fig|536056.3.peg.2466
Escherichia coli DH1 (28-351/421)
S
AE
N
AT
L
K
D
V
EG
NE
Y
I
D
FAA
GI
AVLNT
GH
R
HP
D
L
V
AAV
-
E
Q
Q
LQQFT
H
TAYQIVPY
E
SY
V
T
L
A
E
K
I
NALA
P
VSGQAK
T
AFFT
T
G
A
EA
V
E
N
A
V
K
I
AR
AHTG-----
-
R
PGV
I
A
F
S
G
G
F
HG
R
T
--------
YM
TM
A
L
TGKVAP
-
YKIGF
G
PF
P
G
S
VYHVPYPSDLHGISTQDSLDAIERLFKS
D
IEAKQV
AAII
F
EPV
-
QG
E
GG
FNVAP
K
E
L
V
AA
I
R
R
LCDE
H
GI
V
M
I
A
DEV
QS
G
FA
RTG
K
LFA
MDHYADK
PDL
M
T
M
AK
S
L
A
GG
-
MPL
S
G
VV
G
N
A
N
I
M
D
A
PA
PG
G
--
---L
G
G
T
YA
GNPLA
V
AAA
H
A
V
L
NIIDKESLC
E
RANQLGQ
RL
K
N
T
L
ID
A
K
E
SVPAIA
A
VRGLG
fig|340185.3.peg.911
Escherichia coli E22 (28-351/421)
S
AE
N
AT
L
K
D
V
EG
NE
Y
I
D
FAA
GI
AVLNT
GH
R
HP
D
L
V
AAV
-
E
Q
Q
LQQFT
H
TAYQIVPY
E
SY
V
T
L
A
E
K
I
NALA
P
VSGQAK
T
AFFT
T
G
A
EA
V
E
N
A
V
K
I
AR
AHTG-----
-
R
PGV
I
A
F
S
G
G
F
HG
R
T
--------
YM
TM
A
L
TGKVAP
-
YKIGF
G
PF
P
G
S
VYHVPYPSDLHGISTQDSLDAIERLFKS
D
IEAKQV
AAII
F
EPV
-
QG
E
GG
FNVAP
K
E
L
V
AA
I
R
R
LCDE
H
GI
V
M
I
A
DEV
QS
G
FA
RTG
K
LFA
MDHYADK
PDL
M
T
M
AK
S
L
A
GG
-
MPL
S
G
VV
G
N
A
N
I
M
D
A
PA
PG
G
--
---L
G
G
T
YA
GNPLA
V
AAA
H
A
V
L
NIIDKESLC
E
RANQLGQ
RL
K
N
T
L
ID
A
K
E
SVPAIA
A
VRGLG
fig|340185.4.peg.954
Escherichia coli E22 (28-351/421)
S
AE
N
AT
L
K
D
V
EG
NE
Y
I
D
FAA
GI
AVLNT
GH
R
HP
D
L
V
AAV
-
E
Q
Q
LQQFT
H
TAYQIVPY
E
SY
V
T
L
A
E
K
I
NALA
P
VSGQAK
T
AFFT
T
G
A
EA
V
E
N
A
V
K
I
AR
AHTG-----
-
R
PGV
I
A
F
S
G
G
F
HG
R
T
--------
YM
TM
A
L
TGKVAP
-
YKIGF
G
PF
P
G
S
VYHVPYPSDLHGISTQDSLDAIERLFKS
D
IEAKQV
AAII
F
EPV
-
QG
E
GG
FNVAP
K
E
L
V
AA
I
R
R
LCDE
H
GI
V
M
I
A
DEV
QS
G
FA
RTG
K
LFA
MDHYADK
PDL
M
T
M
AK
S
L
A
GG
-
MPL
S
G
VV
G
N
A
N
I
M
D
A
PA
PG
G
--
---L
G
G
T
YA
GNPLA
V
AAA
H
A
V
L
NIIDKESLC
E
RANQLGQ
RL
K
N
T
L
ID
A
K
E
SVPAIA
A
VRGLG
fig|331111.12.peg.1796
Escherichia coli E24377A (28-351/421)
S
AE
N
AT
L
K
D
V
EG
NE
Y
I
D
FAA
GI
AVLNT
GH
R
HP
D
L
V
AAV
-
E
Q
Q
LQQFT
H
TAYQIVPY
E
SY
V
T
L
A
E
K
I
NALA
P
VSGQAK
T
AFFT
T
G
A
EA
V
E
N
A
V
K
I
AR
AHTG-----
-
R
PGV
I
A
F
S
G
G
F
HG
R
T
--------
YM
TM
A
L
TGKVAP
-
YKIGF
G
PF
P
G
S
VYHVPYPSDLHGISTQDSLDAIERLFKS
D
IEAKQV
AAII
F
EPV
-
QG
E
GG
FNVAP
K
E
L
V
AA
I
R
R
LCDE
H
GI
V
M
I
A
DEV
QS
G
FA
RTG
K
LFA
MDHYADK
PDL
M
T
M
AK
S
L
A
GG
-
MPL
S
G
VV
G
N
A
N
I
M
D
A
PA
PG
G
--
---L
G
G
T
YA
GNPLA
V
AAA
H
A
V
L
NIIDKESLC
E
RANQLGQ
RL
K
N
T
L
ID
A
K
E
SVPAIA
A
VRGLG
fig|331111.3.peg.3958
Escherichia coli E24377A (28-351/421)
S
AE
N
AT
L
K
D
V
EG
NE
Y
I
D
FAA
GI
AVLNT
GH
R
HP
D
L
V
AAV
-
E
Q
Q
LQQFT
H
TAYQIVPY
E
SY
V
T
L
A
E
K
I
NALA
P
VSGQAK
T
AFFT
T
G
A
EA
V
E
N
A
V
K
I
AR
AHTG-----
-
R
PGV
I
A
F
S
G
G
F
HG
R
T
--------
YM
TM
A
L
TGKVAP
-
YKIGF
G
PF
P
G
S
VYHVPYPSDLHGISTQDSLDAIERLFKS
D
IEAKQV
AAII
F
EPV
-
QG
E
GG
FNVAP
K
E
L
V
AA
I
R
R
LCDE
H
GI
V
M
I
A
DEV
QS
G
FA
RTG
K
LFA
MDHYADK
PDL
M
T
M
AK
S
L
A
GG
-
MPL
S
G
VV
G
N
A
N
I
M
D
A
PA
PG
G
--
---L
G
G
T
YA
GNPLA
V
AAA
H
A
V
L
NIIDKESLC
E
RANQLGQ
RL
K
N
T
L
ID
A
K
E
SVPAIA
A
VRGLG
fig|562.375.peg.4208
Escherichia coli EC4100B (28-351/421)
S
AE
N
AT
L
K
D
V
EG
NE
Y
I
D
FAA
GI
AVLNT
GH
R
HP
D
L
V
AAV
-
E
Q
Q
LQQFT
H
TAYQIVPY
E
SY
V
T
L
A
E
K
I
NALA
P
VSGQAK
T
AFFT
T
G
A
EA
V
E
N
A
V
K
I
AR
AHTG-----
-
R
PGV
I
A
F
S
G
G
F
HG
R
T
--------
YM
TM
A
L
TGKVAP
-
YKIGF
G
PF
P
G
S
VYHVPYPSDLHGISTQDSLDAIERLFKS
D
IEAKQV
AAII
F
EPV
-
QG
E
GG
FNVAP
K
E
L
V
AA
I
R
R
LCDE
H
GI
V
M
I
A
DEV
QS
G
FA
RTG
K
LFA
MDHYADK
PDL
M
T
M
AK
S
L
A
GG
-
MPL
S
G
VV
G
N
A
N
I
M
D
A
PA
PG
G
--
---L
G
G
T
YA
GNPLA
V
AAA
H
A
V
L
NIIDKESLC
E
RANQLGQ
RL
K
N
T
L
ID
A
K
E
SVPAIA
A
VRGLG
fig|316401.4.peg.1621
Escherichia coli ETEC H10407 (28-351/421)
S
AE
N
AT
L
K
D
V
EG
NE
Y
I
D
FAA
GI
AVLNT
GH
R
HP
D
L
V
AAV
-
E
Q
Q
LQQFT
H
TAYQIVPY
E
SY
V
T
L
A
E
K
I
NALA
P
VSGQAK
T
AFFT
T
G
A
EA
V
E
N
A
V
K
I
AR
AHTG-----
-
R
PGV
I
A
F
S
G
G
F
HG
R
T
--------
YM
TM
A
L
TGKVAP
-
YKIGF
G
PF
P
G
S
VYHVPYPSDLHGISTQDSLDAIERLFKS
D
IEAKQV
AAII
F
EPV
-
QG
E
GG
FNVAP
K
E
L
V
AA
I
R
R
LCDE
H
GI
V
M
I
A
DEV
QS
G
FA
RTG
K
LFA
MDHYADK
PDL
M
T
M
AK
S
L
A
GG
-
MPL
S
G
VV
G
N
A
N
I
M
D
A
PA
PG
G
--
---L
G
G
T
YA
GNPLA
V
AAA
H
A
V
L
NIIDKESLC
E
RANQLGQ
RL
K
N
T
L
ID
A
K
E
SVPAIA
A
VRGLG
fig|83333.1.peg.1290
Escherichia coli K12 (28-351/421)
S
AE
N
AT
L
K
D
V
EG
NE
Y
I
D
FAA
GI
AVLNT
GH
R
HP
D
L
V
AAV
-
E
Q
Q
LQQFT
H
TAYQIVPY
E
SY
V
T
L
A
E
K
I
NALA
P
VSGQAK
T
AFFT
T
G
A
EA
V
E
N
A
V
K
I
AR
AHTG-----
-
R
PGV
I
A
F
S
G
G
F
HG
R
T
--------
YM
TM
A
L
TGKVAP
-
YKIGF
G
PF
P
G
S
VYHVPYPSDLHGISTQDSLDAIERLFKS
D
IEAKQV
AAII
F
EPV
-
QG
E
GG
FNVAP
K
E
L
V
AA
I
R
R
LCDE
H
GI
V
M
I
A
DEV
QS
G
FA
RTG
K
LFA
MDHYADK
PDL
M
T
M
AK
S
L
A
GG
-
MPL
S
G
VV
G
N
A
N
I
M
D
A
PA
PG
G
--
---L
G
G
T
YA
GNPLA
V
AAA
H
A
V
L
NIIDKESLC
E
RANQLGQ
RL
K
N
T
L
ID
A
K
E
SVPAIA
A
VRGLG
fig|749537.3.peg.3041
Escherichia coli MS 115-1 (28-351/421)
S
AE
N
AT
L
K
D
V
EG
NE
Y
I
D
FAA
GI
AVLNT
GH
R
HP
D
L
V
AAV
-
E
Q
Q
LQQFT
H
TAYQIVPY
E
SY
V
T
L
A
E
K
I
NALA
P
VSGQAK
T
AFFT
T
G
A
EA
V
E
N
A
V
K
I
AR
AHTG-----
-
R
PGV
I
A
F
S
G
G
F
HG
R
T
--------
YM
TM
A
L
TGKVAP
-
YKIGF
G
PF
P
G
S
VYHVPYPSDLHGISTQDSLDAIERLFKS
D
IEAKQV
AAII
F
EPV
-
QG
E
GG
FNVAP
K
E
L
V
AA
I
R
R
LCDE
H
GI
V
M
I
A
DEV
QS
G
FA
RTG
K
LFA
MDHYADK
PDL
M
T
M
AK
S
L
A
GG
-
MPL
S
G
VV
G
N
A
N
I
M
D
A
PA
PG
G
--
---L
G
G
T
YA
GNPLA
V
AAA
H
A
V
L
NIIDKESLC
E
RANQLGQ
RL
K
N
T
L
ID
A
K
E
SVPAIA
A
VRGLG
fig|749538.3.peg.1809
Escherichia coli MS 116-1 (28-351/421)
S
AE
N
AT
L
K
D
V
EG
NE
Y
I
D
FAA
GI
AVLNT
GH
R
HP
D
L
V
AAV
-
E
Q
Q
LQQFT
H
TAYQIVPY
E
SY
V
T
L
A
E
K
I
NALA
P
VSGQAK
T
AFFT
T
G
A
EA
V
E
N
A
V
K
I
AR
AHTG-----
-
R
PGV
I
A
F
S
G
G
F
HG
R
T
--------
YM
TM
A
L
TGKVAP
-
YKIGF
G
PF
P
G
S
VYHVPYPSDLHGISTQDSLDAIERLFKS
D
IEAKQV
AAII
F
EPV
-
QG
E
GG
FNVAP
K
E
L
V
AA
I
R
R
LCDE
H
GI
V
M
I
A
DEV
QS
G
FA
RTG
K
LFA
MDHYADK
PDL
M
T
M
AK
S
L
A
GG
-
MPL
S
G
VV
G
N
A
N
I
M
D
A
PA
PG
G
--
---L
G
G
T
YA
GNPLA
V
AAA
H
A
V
L
NIIDKESLC
E
RANQLGQ
RL
K
N
T
L
ID
A
K
E
SVPAIA
A
VRGLG
fig|679204.3.peg.4001
Escherichia coli MS 145-7 (28-351/421)
S
AE
N
AT
L
K
D
V
EG
NE
Y
I
D
FAA
GI
AVLNT
GH
R
HP
D
L
V
AAV
-
E
Q
Q
LQQFT
H
TAYQIVPY
E
SY
V
T
L
A
E
K
I
NALA
P
VSGQAK
T
AFFT
T
G
A
EA
V
E
N
A
V
K
I
AR
AHTG-----
-
R
PGV
I
A
F
S
G
G
F
HG
R
T
--------
YM
TM
A
L
TGKVAP
-
YKIGF
G
PF
P
G
S
VYHVPYPSDLHGISTQDSLDAIERLFKS
D
IEAKQV
AAII
F
EPV
-
QG
E
GG
FNVAP
K
E
L
V
AA
I
R
R
LCDE
H
GI
V
M
I
A
DEV
QS
G
FA
RTG
K
LFA
MDHYADK
PDL
M
T
M
AK
S
L
A
GG
-
MPL
S
G
VV
G
N
A
N
I
M
D
A
PA
PG
G
--
---L
G
G
T
YA
GNPLA
V
AAA
H
A
V
L
NIIDKESLC
E
RANQLGQ
RL
K
N
T
L
ID
A
K
E
SVPAIA
A
VRGLG
fig|749544.3.peg.473
Escherichia coli MS 175-1 (28-351/421)
S
AE
N
AT
L
K
D
V
EG
NE
Y
I
D
FAA
GI
AVLNT
GH
R
HP
D
L
V
AAV
-
E
Q
Q
LQQFT
H
TAYQIVPY
E
SY
V
T
L
A
E
K
I
NALA
P
VSGQAK
T
AFFT
T
G
A
EA
V
E
N
A
V
K
I
AR
AHTG-----
-
R
PGV
I
A
F
S
G
G
F
HG
R
T
--------
YM
TM
A
L
TGKVAP
-
YKIGF
G
PF
P
G
S
VYHVPYPSDLHGISTQDSLDAIERLFKS
D
IEAKQV
AAII
F
EPV
-
QG
E
GG
FNVAP
K
E
L
V
AA
I
R
R
LCDE
H
GI
V
M
I
A
DEV
QS
G
FA
RTG
K
LFA
MDHYADK
PDL
M
T
M
AK
S
L
A
GG
-
MPL
S
G
VV
G
N
A
N
I
M
D
A
PA
PG
G
--
---L
G
G
T
YA
GNPLA
V
AAA
H
A
V
L
NIIDKESLC
E
RANQLGQ
RL
K
N
T
L
ID
A
K
E
SVPAIA
A
VRGLG
fig|749547.3.peg.182
Escherichia coli MS 187-1 (28-351/421)
S
AE
N
AT
L
K
D
V
EG
NE
Y
I
D
FAA
GI
AVLNT
GH
R
HP
D
L
V
AAV
-
E
Q
Q
LQQFT
H
TAYQIVPY
E
SY
V
T
L
A
E
K
I
NALA
P
VSGQAK
T
AFFT
T
G
A
EA
V
E
N
A
V
K
I
AR
AHTG-----
-
R
PGV
I
A
F
S
G
G
F
HG
R
T
--------
YM
TM
A
L
TGKVAP
-
YKIGF
G
PF
P
G
S
VYHVPYPSDLHGISTQDSLDAIERLFKS
D
IEAKQV
AAII
F
EPV
-
QG
E
GG
FNVAP
K
E
L
V
AA
I
R
R
LCDE
H
GI
V
M
I
A
DEV
QS
G
FA
RTG
K
LFA
MDHYADK
PDL
M
T
M
AK
S
L
A
GG
-
MPL
S
G
VV
G
N
A
N
I
M
D
A
PA
PG
G
--
---L
G
G
T
YA
GNPLA
V
AAA
H
A
V
L
NIIDKESLC
E
RANQLGQ
RL
K
N
T
L
ID
A
K
E
SVPAIA
A
VRGLG
fig|749548.3.peg.1557
Escherichia coli MS 196-1 (28-351/421)
S
AE
N
AT
L
K
D
V
EG
NE
Y
I
D
FAA
GI
AVLNT
GH
R
HP
D
L
V
AAV
-
E
Q
Q
LQQFT
H
TAYQIVPY
E
SY
V
T
L
A
E
K
I
NALA
P
VSGQAK
T
AFFT
T
G
A
EA
V
E
N
A
V
K
I
AR
AHTG-----
-
R
PGV
I
A
F
S
G
G
F
HG
R
T
--------
YM
TM
A
L
TGKVAP
-
YKIGF
G
PF
P
G
S
VYHVPYPSDLHGISTQDSLDAIERLFKS
D
IEAKQV
AAII
F
EPV
-
QG
E
GG
FNVAP
K
E
L
V
AA
I
R
R
LCDE
H
GI
V
M
I
A
DEV
QS
G
FA
RTG
K
LFA
MDHYADK
PDL
M
T
M
AK
S
L
A
GG
-
MPL
S
G
VV
G
N
A
N
I
M
D
A
PA
PG
G
--
---L
G
G
T
YA
GNPLA
V
AAA
H
A
V
L
NIIDKESLC
E
RANQLGQ
RL
K
N
T
L
ID
A
K
E
SVPAIA
A
VRGLG
fig|637912.3.peg.785
Escherichia coli OP50 (28-351/421)
S
AE
N
AT
L
K
D
V
EG
NE
Y
I
D
FAA
GI
AVLNT
GH
R
HP
D
L
V
AAV
-
E
Q
Q
LQQFT
H
TAYQIVPY
E
SY
V
T
L
A
E
K
I
NALA
P
VSGQAK
T
AFFT
T
G
A
EA
V
E
N
A
V
K
I
AR
AHTG-----
-
R
PGV
I
A
F
S
G
G
F
HG
R
T
--------
YM
TM
A
L
TGKVAP
-
YKIGF
G
PF
P
G
S
VYHVPYPSDLHGISTQDSLDAIERLFKS
D
IEAKQV
AAII
F
EPV
-
QG
E
GG
FNVAP
K
E
L
V
AA
I
R
R
LCDE
H
GI
V
M
I
A
DEV
QS
G
FA
RTG
K
LFA
MDHYADK
PDL
M
T
M
AK
S
L
A
GG
-
MPL
S
G
VV
G
N
A
N
I
M
D
A
PA
PG
G
--
---L
G
G
T
YA
GNPLA
V
AAA
H
A
V
L
NIIDKESLC
E
RANQLGQ
RL
K
N
T
L
ID
A
K
E
SVPAIA
A
VRGLG
fig|409438.11.peg.1492
Escherichia coli SE11 (28-351/421)
S
AE
N
AT
L
K
D
V
EG
NE
Y
I
D
FAA
GI
AVLNT
GH
R
HP
D
L
V
AAV
-
E
Q
Q
LQQFT
H
TAYQIVPY
E
SY
V
T
L
A
E
K
I
NALA
P
VSGQAK
T
AFFT
T
G
A
EA
V
E
N
A
V
K
I
AR
AHTG-----
-
R
PGV
I
A
F
S
G
G
F
HG
R
T
--------
YM
TM
A
L
TGKVAP
-
YKIGF
G
PF
P
G
S
VYHVPYPSDLHGISTQDSLDAIERLFKS
D
IEAKQV
AAII
F
EPV
-
QG
E
GG
FNVAP
K
E
L
V
AA
I
R
R
LCDE
H
GI
V
M
I
A
DEV
QS
G
FA
RTG
K
LFA
MDHYADK
PDL
M
T
M
AK
S
L
A
GG
-
MPL
S
G
VV
G
N
A
N
I
M
D
A
PA
PG
G
--
---L
G
G
T
YA
GNPLA
V
AAA
H
A
V
L
NIIDKESLC
E
RANQLGQ
RL
K
N
T
L
ID
A
K
E
SVPAIA
A
VRGLG
fig|316407.3.peg.1264
Escherichia coli W3110 (28-351/421)
S
AE
N
AT
L
K
D
V
EG
NE
Y
I
D
FAA
GI
AVLNT
GH
R
HP
D
L
V
AAV
-
E
Q
Q
LQQFT
H
TAYQIVPY
E
SY
V
T
L
A
E
K
I
NALA
P
VSGQAK
T
AFFT
T
G
A
EA
V
E
N
A
V
K
I
AR
AHTG-----
-
R
PGV
I
A
F
S
G
G
F
HG
R
T
--------
YM
TM
A
L
TGKVAP
-
YKIGF
G
PF
P
G
S
VYHVPYPSDLHGISTQDSLDAIERLFKS
D
IEAKQV
AAII
F
EPV
-
QG
E
GG
FNVAP
K
E
L
V
AA
I
R
R
LCDE
H
GI
V
M
I
A
DEV
QS
G
FA
RTG
K
LFA
MDHYADK
PDL
M
T
M
AK
S
L
A
GG
-
MPL
S
G
VV
G
N
A
N
I
M
D
A
PA
PG
G
--
---L
G
G
T
YA
GNPLA
V
AAA
H
A
V
L
NIIDKESLC
E
RANQLGQ
RL
K
N
T
L
ID
A
K
E
SVPAIA
A
VRGLG
fig|316385.5.peg.1409
Escherichia coli str. K-12 substr. DH10B (28-351/421)
S
AE
N
AT
L
K
D
V
EG
NE
Y
I
D
FAA
GI
AVLNT
GH
R
HP
D
L
V
AAV
-
E
Q
Q
LQQFT
H
TAYQIVPY
E
SY
V
T
L
A
E
K
I
NALA
P
VSGQAK
T
AFFT
T
G
A
EA
V
E
N
A
V
K
I
AR
AHTG-----
-
R
PGV
I
A
F
S
G
G
F
HG
R
T
--------
YM
TM
A
L
TGKVAP
-
YKIGF
G
PF
P
G
S
VYHVPYPSDLHGISTQDSLDAIERLFKS
D
IEAKQV
AAII
F
EPV
-
QG
E
GG
FNVAP
K
E
L
V
AA
I
R
R
LCDE
H
GI
V
M
I
A
DEV
QS
G
FA
RTG
K
LFA
MDHYADK
PDL
M
T
M
AK
S
L
A
GG
-
MPL
S
G
VV
G
N
A
N
I
M
D
A
PA
PG
G
--
---L
G
G
T
YA
GNPLA
V
AAA
H
A
V
L
NIIDKESLC
E
RANQLGQ
RL
K
N
T
L
ID
A
K
E
SVPAIA
A
VRGLG
fig|316385.7.peg.1445
Escherichia coli str. K-12 substr. DH10B (28-351/421)
S
AE
N
AT
L
K
D
V
EG
NE
Y
I
D
FAA
GI
AVLNT
GH
R
HP
D
L
V
AAV
-
E
Q
Q
LQQFT
H
TAYQIVPY
E
SY
V
T
L
A
E
K
I
NALA
P
VSGQAK
T
AFFT
T
G
A
EA
V
E
N
A
V
K
I
AR
AHTG-----
-
R
PGV
I
A
F
S
G
G
F
HG
R
T
--------
YM
TM
A
L
TGKVAP
-
YKIGF
G
PF
P
G
S
VYHVPYPSDLHGISTQDSLDAIERLFKS
D
IEAKQV
AAII
F
EPV
-
QG
E
GG
FNVAP
K
E
L
V
AA
I
R
R
LCDE
H
GI
V
M
I
A
DEV
QS
G
FA
RTG
K
LFA
MDHYADK
PDL
M
T
M
AK
S
L
A
GG
-
MPL
S
G
VV
G
N
A
N
I
M
D
A
PA
PG
G
--
---L
G
G
T
YA
GNPLA
V
AAA
H
A
V
L
NIIDKESLC
E
RANQLGQ
RL
K
N
T
L
ID
A
K
E
SVPAIA
A
VRGLG
fig|511145.12.peg.1358
Escherichia coli str. K-12 substr. MG1655 (28-351/421)
S
AE
N
AT
L
K
D
V
EG
NE
Y
I
D
FAA
GI
AVLNT
GH
R
HP
D
L
V
AAV
-
E
Q
Q
LQQFT
H
TAYQIVPY
E
SY
V
T
L
A
E
K
I
NALA
P
VSGQAK
T
AFFT
T
G
A
EA
V
E
N
A
V
K
I
AR
AHTG-----
-
R
PGV
I
A
F
S
G
G
F
HG
R
T
--------
YM
TM
A
L
TGKVAP
-
YKIGF
G
PF
P
G
S
VYHVPYPSDLHGISTQDSLDAIERLFKS
D
IEAKQV
AAII
F
EPV
-
QG
E
GG
FNVAP
K
E
L
V
AA
I
R
R
LCDE
H
GI
V
M
I
A
DEV
QS
G
FA
RTG
K
LFA
MDHYADK
PDL
M
T
M
AK
S
L
A
GG
-
MPL
S
G
VV
G
N
A
N
I
M
D
A
PA
PG
G
--
---L
G
G
T
YA
GNPLA
V
AAA
H
A
V
L
NIIDKESLC
E
RANQLGQ
RL
K
N
T
L
ID
A
K
E
SVPAIA
A
VRGLG
fig|511145.6.peg.1346
Escherichia coli str. K-12 substr. MG1655 (28-351/421)
S
AE
N
AT
L
K
D
V
EG
NE
Y
I
D
FAA
GI
AVLNT
GH
R
HP
D
L
V
AAV
-
E
Q
Q
LQQFT
H
TAYQIVPY
E
SY
V
T
L
A
E
K
I
NALA
P
VSGQAK
T
AFFT
T
G
A
EA
V
E
N
A
V
K
I
AR
AHTG-----
-
R
PGV
I
A
F
S
G
G
F
HG
R
T
--------
YM
TM
A
L
TGKVAP
-
YKIGF
G
PF
P
G
S
VYHVPYPSDLHGISTQDSLDAIERLFKS
D
IEAKQV
AAII
F
EPV
-
QG
E
GG
FNVAP
K
E
L
V
AA
I
R
R
LCDE
H
GI
V
M
I
A
DEV
QS
G
FA
RTG
K
LFA
MDHYADK
PDL
M
T
M
AK
S
L
A
GG
-
MPL
S
G
VV
G
N
A
N
I
M
D
A
PA
PG
G
--
---L
G
G
T
YA
GNPLA
V
AAA
H
A
V
L
NIIDKESLC
E
RANQLGQ
RL
K
N
T
L
ID
A
K
E
SVPAIA
A
VRGLG
fig|340184.3.peg.232
Escherichia coli B7A (28-351/421)
S
AE
N
AT
L
K
D
V
EG
NE
Y
I
D
FAA
GI
AVLNT
GH
R
HP
D
L
V
AAV
-
E
P
Q
LQQFT
H
TAYQIVPY
E
SY
V
T
L
A
E
K
I
NALA
P
VSGQAK
T
AFFT
T
G
A
EA
V
E
N
A
V
K
I
AR
AHTG-----
-
R
PGV
I
A
F
S
G
G
F
HG
R
T
--------
YM
TM
A
L
TGKVAP
-
YKIGF
G
PF
P
G
S
VYHVPYPSDLHGISTQDSLDAIERLFKS
D
IEAKQV
AAII
F
EPV
-
QG
E
GG
FNVAP
K
E
L
V
AA
I
R
R
LCDE
H
GI
V
M
I
A
DEV
QS
G
FA
RTG
K
LFA
MDHYADK
PDL
M
T
M
AK
S
L
A
GG
-
MPL
S
G
VV
G
N
A
N
I
M
D
A
PA
PG
G
--
---L
G
G
T
YA
GNPLA
V
AAA
H
A
V
L
NIIDKESLC
E
RANQLGQ
RL
K
N
T
L
ID
A
K
E
SVPAIA
A
VRGLG
fig|340184.6.peg.239
Escherichia coli B7A (28-351/421)
S
AE
N
AT
L
K
D
V
EG
NE
Y
I
D
FAA
GI
AVLNT
GH
R
HP
D
L
V
AAV
-
E
P
Q
LQQFT
H
TAYQIVPY
E
SY
V
T
L
A
E
K
I
NALA
P
VSGQAK
T
AFFT
T
G
A
EA
V
E
N
A
V
K
I
AR
AHTG-----
-
R
PGV
I
A
F
S
G
G
F
HG
R
T
--------
YM
TM
A
L
TGKVAP
-
YKIGF
G
PF
P
G
S
VYHVPYPSDLHGISTQDSLDAIERLFKS
D
IEAKQV
AAII
F
EPV
-
QG
E
GG
FNVAP
K
E
L
V
AA
I
R
R
LCDE
H
GI
V
M
I
A
DEV
QS
G
FA
RTG
K
LFA
MDHYADK
PDL
M
T
M
AK
S
L
A
GG
-
MPL
S
G
VV
G
N
A
N
I
M
D
A
PA
PG
G
--
---L
G
G
T
YA
GNPLA
V
AAA
H
A
V
L
NIIDKESLC
E
RANQLGQ
RL
K
N
T
L
ID
A
K
E
SVPAIA
A
VRGLG
fig|595495.4.peg.1081
Escherichia coli KO11 (28-351/421)
S
AE
N
AT
L
K
D
V
EG
NE
Y
I
D
FAA
GI
AVLNT
GH
R
HP
D
L
V
AAV
-
E
Q
Q
LQQFT
H
TAYQIVPY
E
SY
V
T
L
A
E
K
I
NALA
P
VSGQAK
T
AFFT
T
G
A
EA
V
E
N
A
V
K
I
AR
AHTG-----
-
R
PGV
I
A
F
S
G
G
F
HG
R
T
--------
YM
TM
A
L
TGKVAP
-
YKIGF
G
PF
P
G
S
VYHVPYPSDLHGISTQDSLDAIERLFKS
D
IEAKQV
AAII
F
EPV
-
QG
E
GG
FNVAP
K
E
L
V
AA
I
R
R
LCDE
H
GI
V
M
I
A
DEV
QS
G
FA
RTG
K
LFA
MDHYVDK
PDL
M
T
M
AK
S
L
A
GG
-
MPL
S
G
VV
G
N
A
N
I
M
D
A
PA
PG
G
--
---L
G
G
T
YA
GNPLA
V
AAA
H
A
V
L
NIIDKESLC
E
RANQLGQ
RL
K
N
T
L
ID
A
K
E
SVPAIA
A
VRGLG
fig|566546.3.peg.197
Escherichia coli W (28-351/421)
S
AE
N
AT
L
K
D
V
EG
NE
Y
I
D
FAA
GI
AVLNT
GH
R
HP
D
L
V
AAV
-
E
Q
Q
LQQFT
H
TAYQIVPY
E
SY
V
T
L
A
E
K
I
NALA
P
VSGQAK
T
AFFT
T
G
A
EA
V
E
N
A
V
K
I
AR
AHTG-----
-
R
PGV
I
A
F
S
G
G
F
HG
R
T
--------
YM
TM
A
L
TGKVAP
-
YKIGF
G
PF
P
G
S
VYHVPYPSDLHGISTQDSLDAIERLFKS
D
IEAKQV
AAII
F
EPV
-
QG
E
GG
FNVAP
K
E
L
V
AA
I
R
R
LCDE
H
GI
V
M
I
A
DEV
QS
G
FA
RTG
K
LFA
MDHYVDK
PDL
M
T
M
AK
S
L
A
GG
-
MPL
S
G
VV
G
N
A
N
I
M
D
A
PA
PG
G
--
---L
G
G
T
YA
GNPLA
V
AAA
H
A
V
L
NIIDKESLC
E
RANQLGQ
RL
K
N
T
L
ID
A
K
E
SVPAIA
A
VRGLG
fig|566546.4.peg.1393
Escherichia coli W (28-351/421)
S
AE
N
AT
L
K
D
V
EG
NE
Y
I
D
FAA
GI
AVLNT
GH
R
HP
D
L
V
AAV
-
E
Q
Q
LQQFT
H
TAYQIVPY
E
SY
V
T
L
A
E
K
I
NALA
P
VSGQAK
T
AFFT
T
G
A
EA
V
E
N
A
V
K
I
AR
AHTG-----
-
R
PGV
I
A
F
S
G
G
F
HG
R
T
--------
YM
TM
A
L
TGKVAP
-
YKIGF
G
PF
P
G
S
VYHVPYPSDLHGISTQDSLDAIERLFKS
D
IEAKQV
AAII
F
EPV
-
QG
E
GG
FNVAP
K
E
L
V
AA
I
R
R
LCDE
H
GI
V
M
I
A
DEV
QS
G
FA
RTG
K
LFA
MDHYVDK
PDL
M
T
M
AK
S
L
A
GG
-
MPL
S
G
VV
G
N
A
N
I
M
D
A
PA
PG
G
--
---L
G
G
T
YA
GNPLA
V
AAA
H
A
V
L
NIIDKESLC
E
RANQLGQ
RL
K
N
T
L
ID
A
K
E
SVPAIA
A
VRGLG
fig|749531.3.peg.277
Escherichia coli MS 69-1 (28-351/421)
S
AE
N
AT
L
K
D
V
EG
NE
Y
I
D
FAA
GI
AVLNT
GH
R
HP
D
L
V
AAV
-
E
Q
Q
LQQFT
H
TAYQIVPY
E
SY
V
T
L
A
E
K
I
NALA
P
VSGQAK
T
AFFT
T
G
A
EA
V
E
N
A
V
K
I
AR
AHTG-----
-
R
PGV
I
A
F
S
G
G
F
HG
R
T
--------
YM
TM
A
L
TGKVAP
-
YKIGF
G
PF
P
G
S
VYHVPYPSDLHGVSTQDSLDAIERLFKS
D
IEAKQV
AAII
F
EPV
-
QG
E
GG
FNVAP
T
E
L
V
AA
I
R
R
LCDE
H
GI
V
M
I
A
DEV
QS
G
FA
RTG
K
LFA
MDHYADK
PDL
M
T
M
AK
S
L
A
GG
-
MPL
S
G
VV
G
N
A
N
I
M
D
A
PA
PG
G
--
---L
G
G
T
YA
GNPLA
V
AAA
H
A
V
L
NIIDKESLC
E
RANQLGQ
RL
T
N
T
L
ID
A
K
E
SVPAIA
A
VRGLG
fig|216592.1.peg.1820
Escherichia coli 042 (28-351/421)
S
AE
N
AT
L
K
D
V
EG
NE
Y
I
D
FAA
GI
AVLNT
GH
R
HP
D
L
V
AAV
-
E
Q
Q
LQQFT
H
TAYQIVPY
E
SY
V
T
L
A
E
K
I
NALA
P
VSGQAK
T
AFFT
T
G
A
EA
V
E
N
A
V
K
I
AR
AHTG-----
-
R
PGV
I
A
F
S
G
G
F
HG
R
T
--------
YM
TM
A
L
TGKVAP
-
YKIGF
G
PF
P
G
S
VYHVPYPSDLHGVSTQDSLDAIERLFKS
D
IEAKQV
AAII
F
EPV
-
QG
E
GG
FNVAP
K
E
L
V
AA
I
R
R
LCDE
H
GI
V
M
I
A
DEV
QS
G
FA
RTG
K
LFA
MDHYADK
PDL
M
T
M
AK
S
L
A
GG
-
MPL
S
G
VV
G
N
A
N
I
M
D
A
PA
PG
G
--
---L
G
G
T
YA
GNPLA
V
AAA
H
A
V
L
NIIDKESLC
E
RANQLGQ
RL
T
N
T
L
ID
A
K
E
SVPAIA
A
VRGLG
fig|216592.3.peg.1482
Escherichia coli 042 (28-351/421)
S
AE
N
AT
L
K
D
V
EG
NE
Y
I
D
FAA
GI
AVLNT
GH
R
HP
D
L
V
AAV
-
E
Q
Q
LQQFT
H
TAYQIVPY
E
SY
V
T
L
A
E
K
I
NALA
P
VSGQAK
T
AFFT
T
G
A
EA
V
E
N
A
V
K
I
AR
AHTG-----
-
R
PGV
I
A
F
S
G
G
F
HG
R
T
--------
YM
TM
A
L
TGKVAP
-
YKIGF
G
PF
P
G
S
VYHVPYPSDLHGVSTQDSLDAIERLFKS
D
IEAKQV
AAII
F
EPV
-
QG
E
GG
FNVAP
K
E
L
V
AA
I
R
R
LCDE
H
GI
V
M
I
A
DEV
QS
G
FA
RTG
K
LFA
MDHYADK
PDL
M
T
M
AK
S
L
A
GG
-
MPL
S
G
VV
G
N
A
N
I
M
D
A
PA
PG
G
--
---L
G
G
T
YA
GNPLA
V
AAA
H
A
V
L
NIIDKESLC
E
RANQLGQ
RL
T
N
T
L
ID
A
K
E
SVPAIA
A
VRGLG
fig|550677.3.peg.2769
Escherichia coli B354 (28-351/421)
S
AE
N
AT
L
K
D
V
EG
NE
Y
I
D
FAA
GI
AVLNT
GH
R
HP
D
L
V
AAV
-
E
Q
Q
LQQFT
H
TAYQIVPY
E
SY
V
T
L
A
E
K
I
NALA
P
VSGQAK
T
AFFT
T
G
A
EA
V
E
N
A
V
K
I
AR
AHTG-----
-
R
PGV
I
A
F
S
G
G
F
HG
R
T
--------
YM
TM
A
L
TGKVAP
-
YKIGF
G
PF
P
G
S
VYHVPYPSDLHGVSTQDSLDAIERLFKS
D
IEAKQV
AAII
F
EPV
-
QG
E
GG
FNVAP
K
E
L
V
AA
I
R
R
LCDE
H
GI
V
M
I
A
DEV
QS
G
FA
RTG
K
LFA
MDHYADK
PDL
M
T
M
AK
S
L
A
GG
-
MPL
S
G
VV
G
N
A
N
I
M
D
A
PA
PG
G
--
---L
G
G
T
YA
GNPLA
V
AAA
Q
A
V
L
NIIDKESLC
E
RANQLGQ
RL
T
N
T
L
ID
A
K
E
SVPAIA
A
VRGLG
fig|656437.3.peg.1466
Escherichia coli TA143 (28-351/421)
S
AE
N
AT
L
K
D
V
EG
NE
Y
I
D
FAA
GI
AVLNT
GH
R
HP
D
L
V
AAV
-
E
Q
Q
LQQFT
H
TAYQIVPY
E
SY
V
T
L
A
E
K
I
NALA
P
VSGQAK
T
AFFT
T
G
A
EA
V
E
N
A
V
K
I
AR
AHTG-----
-
R
PGV
I
A
F
S
G
G
F
HG
R
T
--------
YM
TM
A
L
TGKVAP
-
YKIGF
G
PF
P
G
S
VYHVPYPSDLHGVSTQDSLDAIERLFKS
D
IEAKQV
AAII
F
EPV
-
QG
E
GG
FNVAP
K
E
L
V
AA
I
R
R
LCDE
H
GI
V
M
I
A
DEV
QS
G
FA
RTG
K
LFA
MDHYADK
PDL
M
T
M
AK
S
L
A
GG
-
MPL
S
G
VV
G
N
A
N
I
M
D
A
PA
PG
G
--
---L
G
G
T
YA
GNPLA
V
AAA
H
A
V
L
NIIDKESLC
E
RANQLGQ
RL
T
N
T
L
ID
A
K
E
SVPAIA
A
VRGLG
fig|656444.3.peg.2040
Escherichia coli TA280 (28-351/421)
S
AE
N
AT
L
K
D
V
EG
NE
Y
I
D
FAA
GI
AVLNT
GH
R
HP
D
L
V
AAV
-
E
Q
Q
LQQFT
H
TAYQIVPY
E
SY
V
T
L
A
E
K
I
NALA
P
VSGQAK
T
AFFT
T
G
A
EA
V
E
N
A
V
K
I
AR
AHTG-----
-
R
PGV
I
A
F
S
G
G
F
HG
R
T
--------
YM
TM
A
L
TGKVAP
-
YKIGF
G
PF
P
G
S
VYHVPYPSDLHGVSTQDSLDAIERLFKS
D
IEAKQV
AAII
F
EPV
-
QG
E
GG
FNVAP
K
E
L
V
AA
I
R
R
LCDE
H
GI
V
M
I
A
DEV
QS
G
FA
RTG
K
LFA
MDHYADK
PDL
M
T
M
AK
S
L
A
GG
-
MPL
S
G
VV
G
N
A
N
I
M
D
A
PA
PG
G
--
---L
G
G
T
YA
GNPLA
V
AAA
H
A
V
L
NIIDKESLC
E
RANQLGQ
RL
T
N
T
L
ID
A
K
E
SVPAIA
A
VRGLG
fig|562.371.peg.1396
Escherichia coli 1044A (28-351/421)
S
AE
N
AT
L
K
D
V
EG
NE
Y
I
D
FAA
GI
AVLNT
GH
R
HP
D
L
V
AAV
-
E
Q
Q
LQQFT
H
TAYQIVPY
E
SY
V
T
L
A
E
K
I
NALA
P
VSGQAK
T
AFFT
T
G
A
EA
V
E
N
A
V
K
I
AR
AHTG-----
-
R
PGV
I
A
F
S
G
G
F
HG
R
T
--------
YM
TM
A
L
TGKVAP
-
YKIGF
G
PF
P
G
S
VYHVPYPSDLHGISTQDSLDAIERLFKS
D
IEAKQV
AAII
F
EPV
-
QG
E
GG
FNVAP
K
E
L
V
AA
I
R
R
LCDE
H
GI
V
M
I
A
DEV
QS
G
FA
RTG
K
LFA
MDHYADK
PDL
M
T
M
AK
S
L
A
GG
-
MPL
S
G
VV
G
N
A
N
I
M
D
A
PA
PG
G
--
---L
G
G
T
YA
GNPLA
V
AAA
H
A
V
L
NIIDKESLC
E
RAMQLGQ
RL
T
K
T
L
ID
A
K
E
NVPAIA
A
VRGLG
fig|562.373.peg.5222
Escherichia coli 1125A (28-351/421)
S
AE
N
AT
L
K
D
V
EG
NE
Y
I
D
FAA
GI
AVLNT
GH
R
HP
D
L
V
AAV
-
E
Q
Q
LQQFT
H
TAYQIVPY
E
SY
V
T
L
A
E
K
I
NALA
P
VSGQAK
T
AFFT
T
G
A
EA
V
E
N
A
V
K
I
AR
AHTG-----
-
R
PGV
I
A
F
S
G
G
F
HG
R
T
--------
YM
TM
A
L
TGKVAP
-
YKIGF
G
PF
P
G
S
VYHVPYPSDLHGISTQDSLDAIERLFKS
D
IEAKQV
AAII
F
EPV
-
QG
E
GG
FNVAP
K
E
L
V
AA
I
R
R
LCDE
H
GI
V
M
I
A
DEV
QS
G
FA
RTG
K
LFA
MDHYADK
PDL
M
T
M
AK
S
L
A
GG
-
MPL
S
G
VV
G
N
A
N
I
M
D
A
PA
PG
G
--
---L
G
G
T
YA
GNPLA
V
AAA
H
A
V
L
NIIDKESLC
E
RAMQLGQ
RL
T
K
T
L
ID
A
K
E
NVPAIA
A
VRGLG
fig|562.372.peg.851
Escherichia coli 1212A (28-351/421)
S
AE
N
AT
L
K
D
V
EG
NE
Y
I
D
FAA
GI
AVLNT
GH
R
HP
D
L
V
AAV
-
E
Q
Q
LQQFT
H
TAYQIVPY
E
SY
V
T
L
A
E
K
I
NALA
P
VSGQAK
T
AFFT
T
G
A
EA
V
E
N
A
V
K
I
AR
AHTG-----
-
R
PGV
I
A
F
S
G
G
F
HG
R
T
--------
YM
TM
A
L
TGKVAP
-
YKIGF
G
PF
P
G
S
VYHVPYPSDLHGISTQDSLDAIERLFKS
D
IEAKQV
AAII
F
EPV
-
QG
E
GG
FNVAP
K
E
L
V
AA
I
R
R
LCDE
H
GI
V
M
I
A
DEV
QS
G
FA
RTG
K
LFA
MDHYADK
PDL
M
T
M
AK
S
L
A
GG
-
MPL
S
G
VV
G
N
A
N
I
M
D
A
PA
PG
G
--
---L
G
G
T
YA
GNPLA
V
AAA
H
A
V
L
NIIDKESLC
E
RAMQLGQ
RL
T
K
T
L
ID
A
K
E
NVPAIA
A
VRGLG
fig|562.374.peg.6077
Escherichia coli 536A (28-351/421)
S
AE
N
AT
L
K
D
V
EG
NE
Y
I
D
FAA
GI
AVLNT
GH
R
HP
D
L
V
AAV
-
E
Q
Q
LQQFT
H
TAYQIVPY
E
SY
V
T
L
A
E
K
I
NALA
P
VSGQAK
T
AFFT
T
G
A
EA
V
E
N
A
V
K
I
AR
AHTG-----
-
R
PGV
I
A
F
S
G
G
F
HG
R
T
--------
YM
TM
A
L
TGKVAP
-
YKIGF
G
PF
P
G
S
VYHVPYPSDLHGISTQDSLDAIERLFKS
D
IEAKQV
AAII
F
EPV
-
QG
E
GG
FNVAP
K
E
L
V
AA
I
R
R
LCDE
H
GI
V
M
I
A
DEV
QS
G
FA
RTG
K
LFA
MDHYADK
PDL
M
T
M
AK
S
L
A
GG
-
MPL
S
G
VV
G
N
A
N
I
M
D
A
PA
PG
G
--
---L
G
G
T
YA
GNPLA
V
AAA
H
A
V
L
NIIDKESLC
E
RAMQLGQ
RL
T
K
T
L
ID
A
K
E
NVPAIA
A
VRGLG
fig|83334.1.peg.1914
Escherichia coli O157:H7 (28-351/421)
S
AE
N
AT
L
K
D
V
EG
NE
Y
I
D
FAA
GI
AVLNT
GH
R
HP
D
L
V
AAV
-
E
Q
Q
LQQFT
H
TAYQIVPY
E
SY
V
T
L
A
E
K
I
NALA
P
VSGQAK
T
AFFT
T
G
A
EA
V
E
N
A
V
K
I
AR
AHTG-----
-
R
PGV
I
A
F
S
G
G
F
HG
R
T
--------
YM
TM
A
L
TGKVAP
-
YKIGF
G
PF
P
G
S
VYHVPYPSDLHGISTQDSLDAIERLFKS
D
IEAKQV
AAII
F
EPV
-
QG
E
GG
FNVAP
K
E
L
V
AA
I
R
R
LCDE
H
GI
V
M
I
A
DEV
QS
G
FA
RTG
K
LFA
MDHYADK
PDL
M
T
M
AK
S
L
A
GG
-
MPL
S
G
VV
G
N
A
N
I
M
D
A
PA
PG
G
--
---L
G
G
T
YA
GNPLA
V
AAA
H
A
V
L
NIIDKESLC
E
RAMQLGQ
RL
T
K
T
L
ID
A
K
E
NVPAIA
A
VRGLG
fig|155864.1.peg.2194
Escherichia coli O157:H7 EDL933 (28-351/421)
S
AE
N
AT
L
K
D
V
EG
NE
Y
I
D
FAA
GI
AVLNT
GH
R
HP
D
L
V
AAV
-
E
Q
Q
LQQFT
H
TAYQIVPY
E
SY
V
T
L
A
E
K
I
NALA
P
VSGQAK
T
AFFT
T
G
A
EA
V
E
N
A
V
K
I
AR
AHTG-----
-
R
PGV
I
A
F
S
G
G
F
HG
R
T
--------
YM
TM
A
L
TGKVAP
-
YKIGF
G
PF
P
G
S
VYHVPYPSDLHGISTQDSLDAIERLFKS
D
IEAKQV
AAII
F
EPV
-
QG
E
GG
FNVAP
K
E
L
V
AA
I
R
R
LCDE
H
GI
V
M
I
A
DEV
QS
G
FA
RTG
K
LFA
MDHYADK
PDL
M
T
M
AK
S
L
A
GG
-
MPL
S
G
VV
G
N
A
N
I
M
D
A
PA
PG
G
--
---L
G
G
T
YA
GNPLA
V
AAA
H
A
V
L
NIIDKESLC
E
RAMQLGQ
RL
T
K
T
L
ID
A
K
E
NVPAIA
A
VRGLG
fig|155864.8.peg.2029
Escherichia coli O157:H7 EDL933 (28-351/421)
S
AE
N
AT
L
K
D
V
EG
NE
Y
I
D
FAA
GI
AVLNT
GH
R
HP
D
L
V
AAV
-
E
Q
Q
LQQFT
H
TAYQIVPY
E
SY
V
T
L
A
E
K
I
NALA
P
VSGQAK
T
AFFT
T
G
A
EA
V
E
N
A
V
K
I
AR
AHTG-----
-
R
PGV
I
A
F
S
G
G
F
HG
R
T
--------
YM
TM
A
L
TGKVAP
-
YKIGF
G
PF
P
G
S
VYHVPYPSDLHGISTQDSLDAIERLFKS
D
IEAKQV
AAII
F
EPV
-
QG
E
GG
FNVAP
K
E
L
V
AA
I
R
R
LCDE
H
GI
V
M
I
A
DEV
QS
G
FA
RTG
K
LFA
MDHYADK
PDL
M
T
M
AK
S
L
A
GG
-
MPL
S
G
VV
G
N
A
N
I
M
D
A
PA
PG
G
--
---L
G
G
T
YA
GNPLA
V
AAA
H
A
V
L
NIIDKESLC
E
RAMQLGQ
RL
T
K
T
L
ID
A
K
E
NVPAIA
A
VRGLG
fig|444454.5.peg.277
Escherichia coli O157:H7 str. EC4024 (28-351/421)
S
AE
N
AT
L
K
D
V
EG
NE
Y
I
D
FAA
GI
AVLNT
GH
R
HP
D
L
V
AAV
-
E
Q
Q
LQQFT
H
TAYQIVPY
E
SY
V
T
L
A
E
K
I
NALA
P
VSGQAK
T
AFFT
T
G
A
EA
V
E
N
A
V
K
I
AR
AHTG-----
-
R
PGV
I
A
F
S
G
G
F
HG
R
T
--------
YM
TM
A
L
TGKVAP
-
YKIGF
G
PF
P
G
S
VYHVPYPSDLHGISTQDSLDAIERLFKS
D
IEAKQV
AAII
F
EPV
-
QG
E
GG
FNVAP
K
E
L
V
AA
I
R
R
LCDE
H
GI
V
M
I
A
DEV
QS
G
FA
RTG
K
LFA
MDHYADK
PDL
M
T
M
AK
S
L
A
GG
-
MPL
S
G
VV
G
N
A
N
I
M
D
A
PA
PG
G
--
---L
G
G
T
YA
GNPLA
V
AAA
H
A
V
L
NIIDKESLC
E
RAMQLGQ
RL
T
K
T
L
ID
A
K
E
NVPAIA
A
VRGLG
fig|444449.5.peg.177
Escherichia coli O157:H7 str. EC4042 (28-351/421)
S
AE
N
AT
L
K
D
V
EG
NE
Y
I
D
FAA
GI
AVLNT
GH
R
HP
D
L
V
AAV
-
E
Q
Q
LQQFT
H
TAYQIVPY
E
SY
V
T
L
A
E
K
I
NALA
P
VSGQAK
T
AFFT
T
G
A
EA
V
E
N
A
V
K
I
AR
AHTG-----
-
R
PGV
I
A
F
S
G
G
F
HG
R
T
--------
YM
TM
A
L
TGKVAP
-
YKIGF
G
PF
P
G
S
VYHVPYPSDLHGISTQDSLDAIERLFKS
D
IEAKQV
AAII
F
EPV
-
QG
E
GG
FNVAP
K
E
L
V
AA
I
R
R
LCDE
H
GI
V
M
I
A
DEV
QS
G
FA
RTG
K
LFA
MDHYADK
PDL
M
T
M
AK
S
L
A
GG
-
MPL
S
G
VV
G
N
A
N
I
M
D
A
PA
PG
G
--
---L
G
G
T
YA
GNPLA
V
AAA
H
A
V
L
NIIDKESLC
E
RAMQLGQ
RL
T
K
T
L
ID
A
K
E
NVPAIA
A
VRGLG
fig|444448.5.peg.4533
Escherichia coli O157:H7 str. EC4045 (28-351/421)
S
AE
N
AT
L
K
D
V
EG
NE
Y
I
D
FAA
GI
AVLNT
GH
R
HP
D
L
V
AAV
-
E
Q
Q
LQQFT
H
TAYQIVPY
E
SY
V
T
L
A
E
K
I
NALA
P
VSGQAK
T
AFFT
T
G
A
EA
V
E
N
A
V
K
I
AR
AHTG-----
-
R
PGV
I
A
F
S
G
G
F
HG
R
T
--------
YM
TM
A
L
TGKVAP
-
YKIGF
G
PF
P
G
S
VYHVPYPSDLHGISTQDSLDAIERLFKS
D
IEAKQV
AAII
F
EPV
-
QG
E
GG
FNVAP
K
E
L
V
AA
I
R
R
LCDE
H
GI
V
M
I
A
DEV
QS
G
FA
RTG
K
LFA
MDHYADK
PDL
M
T
M
AK
S
L
A
GG
-
MPL
S
G
VV
G
N
A
N
I
M
D
A
PA
PG
G
--
---L
G
G
T
YA
GNPLA
V
AAA
H
A
V
L
NIIDKESLC
E
RAMQLGQ
RL
T
K
T
L
ID
A
K
E
NVPAIA
A
VRGLG
fig|444453.5.peg.4142
Escherichia coli O157:H7 str. EC4076 (28-351/421)
S
AE
N
AT
L
K
D
V
EG
NE
Y
I
D
FAA
GI
AVLNT
GH
R
HP
D
L
V
AAV
-
E
Q
Q
LQQFT
H
TAYQIVPY
E
SY
V
T
L
A
E
K
I
NALA
P
VSGQAK
T
AFFT
T
G
A
EA
V
E
N
A
V
K
I
AR
AHTG-----
-
R
PGV
I
A
F
S
G
G
F
HG
R
T
--------
YM
TM
A
L
TGKVAP
-
YKIGF
G
PF
P
G
S
VYHVPYPSDLHGISTQDSLDAIERLFKS
D
IEAKQV
AAII
F
EPV
-
QG
E
GG
FNVAP
K
E
L
V
AA
I
R
R
LCDE
H
GI
V
M
I
A
DEV
QS
G
FA
RTG
K
LFA
MDHYADK
PDL
M
T
M
AK
S
L
A
GG
-
MPL
S
G
VV
G
N
A
N
I
M
D
A
PA
PG
G
--
---L
G
G
T
YA
GNPLA
V
AAA
H
A
V
L
NIIDKESLC
E
RAMQLGQ
RL
T
K
T
L
ID
A
K
E
NVPAIA
A
VRGLG
fig|444452.5.peg.2090
Escherichia coli O157:H7 str. EC4113 (28-351/421)
S
AE
N
AT
L
K
D
V
EG
NE
Y
I
D
FAA
GI
AVLNT
GH
R
HP
D
L
V
AAV
-
E
Q
Q
LQQFT
H
TAYQIVPY
E
SY
V
T
L
A
E
K
I
NALA
P
VSGQAK
T
AFFT
T
G
A
EA
V
E
N
A
V
K
I
AR
AHTG-----
-
R
PGV
I
A
F
S
G
G
F
HG
R
T
--------
YM
TM
A
L
TGKVAP
-
YKIGF
G
PF
P
G
S
VYHVPYPSDLHGISTQDSLDAIERLFKS
D
IEAKQV
AAII
F
EPV
-
QG
E
GG
FNVAP
K
E
L
V
AA
I
R
R
LCDE
H
GI
V
M
I
A
DEV
QS
G
FA
RTG
K
LFA
MDHYADK
PDL
M
T
M
AK
S
L
A
GG
-
MPL
S
G
VV
G
N
A
N
I
M
D
A
PA
PG
G
--
---L
G
G
T
YA
GNPLA
V
AAA
H
A
V
L
NIIDKESLC
E
RAMQLGQ
RL
T
K
T
L
ID
A
K
E
NVPAIA
A
VRGLG
fig|444450.8.peg.1995
Escherichia coli O157:H7 str. EC4115 (28-351/421)
S
AE
N
AT
L
K
D
V
EG
NE
Y
I
D
FAA
GI
AVLNT
GH
R
HP
D
L
V
AAV
-
E
Q
Q
LQQFT
H
TAYQIVPY
E
SY
V
T
L
A
E
K
I
NALA
P
VSGQAK
T
AFFT
T
G
A
EA
V
E
N
A
V
K
I
AR
AHTG-----
-
R
PGV
I
A
F
S
G
G
F
HG
R
T
--------
YM
TM
A
L
TGKVAP
-
YKIGF
G
PF
P
G
S
VYHVPYPSDLHGISTQDSLDAIERLFKS
D
IEAKQV
AAII
F
EPV
-
QG
E
GG
FNVAP
K
E
L
V
AA
I
R
R
LCDE
H
GI
V
M
I
A
DEV
QS
G
FA
RTG
K
LFA
MDHYADK
PDL
M
T
M
AK
S
L
A
GG
-
MPL
S
G
VV
G
N
A
N
I
M
D
A
PA
PG
G
--
---L
G
G
T
YA
GNPLA
V
AAA
H
A
V
L
NIIDKESLC
E
RAMQLGQ
RL
T
K
T
L
ID
A
K
E
NVPAIA
A
VRGLG
fig|444451.5.peg.2740
Escherichia coli O157:H7 str. EC4196 (28-351/421)
S
AE
N
AT
L
K
D
V
EG
NE
Y
I
D
FAA
GI
AVLNT
GH
R
HP
D
L
V
AAV
-
E
Q
Q
LQQFT
H
TAYQIVPY
E
SY
V
T
L
A
E
K
I
NALA
P
VSGQAK
T
AFFT
T
G
A
EA
V
E
N
A
V
K
I
AR
AHTG-----
-
R
PGV
I
A
F
S
G
G
F
HG
R
T
--------
YM
TM
A
L
TGKVAP
-
YKIGF
G
PF
P
G
S
VYHVPYPSDLHGISTQDSLDAIERLFKS
D
IEAKQV
AAII
F
EPV
-
QG
E
GG
FNVAP
K
E
L
V
AA
I
R
R
LCDE
H
GI
V
M
I
A
DEV
QS
G
FA
RTG
K
LFA
MDHYADK
PDL
M
T
M
AK
S
L
A
GG
-
MPL
S
G
VV
G
N
A
N
I
M
D
A
PA
PG
G
--
---L
G
G
T
YA
GNPLA
V
AAA
H
A
V
L
NIIDKESLC
E
RAMQLGQ
RL
T
K
T
L
ID
A
K
E
NVPAIA
A
VRGLG
fig|444447.5.peg.5442
Escherichia coli O157:H7 str. EC4206 (28-351/421)
S
AE
N
AT
L
K
D
V
EG
NE
Y
I
D
FAA
GI
AVLNT
GH
R
HP
D
L
V
AAV
-
E
Q
Q
LQQFT
H
TAYQIVPY
E
SY
V
T
L
A
E
K
I
NALA
P
VSGQAK
T
AFFT
T
G
A
EA
V
E
N
A
V
K
I
AR
AHTG-----
-
R
PGV
I
A
F
S
G
G
F
HG
R
T
--------
YM
TM
A
L
TGKVAP
-
YKIGF
G
PF
P
G
S
VYHVPYPSDLHGISTQDSLDAIERLFKS
D
IEAKQV
AAII
F
EPV
-
QG
E
GG
FNVAP
K
E
L
V
AA
I
R
R
LCDE
H
GI
V
M
I
A
DEV
QS
G
FA
RTG
K
LFA
MDHYADK
PDL
M
T
M
AK
S
L
A
GG
-
MPL
S
G
VV
G
N
A
N
I
M
D
A
PA
PG
G
--
---L
G
G
T
YA
GNPLA
V
AAA
H
A
V
L
NIIDKESLC
E
RAMQLGQ
RL
T
K
T
L
ID
A
K
E
NVPAIA
A
VRGLG
fig|478004.5.peg.2724
Escherichia coli O157:H7 str. EC4401 (28-351/421)
S
AE
N
AT
L
K
D
V
EG
NE
Y
I
D
FAA
GI
AVLNT
GH
R
HP
D
L
V
AAV
-
E
Q
Q
LQQFT
H
TAYQIVPY
E
SY
V
T
L
A
E
K
I
NALA
P
VSGQAK
T
AFFT
T
G
A
EA
V
E
N
A
V
K
I
AR
AHTG-----
-
R
PGV
I
A
F
S
G
G
F
HG
R
T
--------
YM
TM
A
L
TGKVAP
-
YKIGF
G
PF
P
G
S
VYHVPYPSDLHGISTQDSLDAIERLFKS
D
IEAKQV
AAII
F
EPV
-
QG
E
GG
FNVAP
K
E
L
V
AA
I
R
R
LCDE
H
GI
V
M
I
A
DEV
QS
G
FA
RTG
K
LFA
MDHYADK
PDL
M
T
M
AK
S
L
A
GG
-
MPL
S
G
VV
G
N
A
N
I
M
D
A
PA
PG
G
--
---L
G
G
T
YA
GNPLA
V
AAA
H
A
V
L
NIIDKESLC
E
RAMQLGQ
RL
T
K
T
L
ID
A
K
E
NVPAIA
A
VRGLG
fig|478005.5.peg.3305
Escherichia coli O157:H7 str. EC4486 (28-351/421)
S
AE
N
AT
L
K
D
V
EG
NE
Y
I
D
FAA
GI
AVLNT
GH
R
HP
D
L
V
AAV
-
E
Q
Q
LQQFT
H
TAYQIVPY
E
SY
V
T
L
A
E
K
I
NALA
P
VSGQAK
T
AFFT
T
G
A
EA
V
E
N
A
V
K
I
AR
AHTG-----
-
R
PGV
I
A
F
S
G
G
F
HG
R
T
--------
YM
TM
A
L
TGKVAP
-
YKIGF
G
PF
P
G
S
VYHVPYPSDLHGISTQDSLDAIERLFKS
D
IEAKQV
AAII
F
EPV
-
QG
E
GG
FNVAP
K
E
L
V
AA
I
R
R
LCDE
H
GI
V
M
I
A
DEV
QS
G
FA
RTG
K
LFA
MDHYADK
PDL
M
T
M
AK
S
L
A
GG
-
MPL
S
G
VV
G
N
A
N
I
M
D
A
PA
PG
G
--
---L
G
G
T
YA
GNPLA
V
AAA
H
A
V
L
NIIDKESLC
E
RAMQLGQ
RL
T
K
T
L
ID
A
K
E
NVPAIA
A
VRGLG
fig|478006.5.peg.3122
Escherichia coli O157:H7 str. EC4501 (28-351/421)
S
AE
N
AT
L
K
D
V
EG
NE
Y
I
D
FAA
GI
AVLNT
GH
R
HP
D
L
V
AAV
-
E
Q
Q
LQQFT
H
TAYQIVPY
E
SY
V
T
L
A
E
K
I
NALA
P
VSGQAK
T
AFFT
T
G
A
EA
V
E
N
A
V
K
I
AR
AHTG-----
-
R
PGV
I
A
F
S
G
G
F
HG
R
T
--------
YM
TM
A
L
TGKVAP
-
YKIGF
G
PF
P
G
S
VYHVPYPSDLHGISTQDSLDAIERLFKS
D
IEAKQV
AAII
F
EPV
-
QG
E
GG
FNVAP
K
E
L
V
AA
I
R
R
LCDE
H
GI
V
M
I
A
DEV
QS
G
FA
RTG
K
LFA
MDHYADK
PDL
M
T
M
AK
S
L
A
GG
-
MPL
S
G
VV
G
N
A
N
I
M
D
A
PA
PG
G
--
---L
G
G
T
YA
GNPLA
V
AAA
H
A
V
L
NIIDKESLC
E
RAMQLGQ
RL
T
K
T
L
ID
A
K
E
NVPAIA
A
VRGLG
fig|478007.5.peg.2343
Escherichia coli O157:H7 str. EC508 (28-351/421)
S
AE
N
AT
L
K
D
V
EG
NE
Y
I
D
FAA
GI
AVLNT
GH
R
HP
D
L
V
AAV
-
E
Q
Q
LQQFT
H
TAYQIVPY
E
SY
V
T
L
A
E
K
I
NALA
P
VSGQAK
T
AFFT
T
G
A
EA
V
E
N
A
V
K
I
AR
AHTG-----
-
R
PGV
I
A
F
S
G
G
F
HG
R
T
--------
YM
TM
A
L
TGKVAP
-
YKIGF
G
PF
P
G
S
VYHVPYPSDLHGISTQDSLDAIERLFKS
D
IEAKQV
AAII
F
EPV
-
QG
E
GG
FNVAP
K
E
L
V
AA
I
R
R
LCDE
H
GI
V
M
I
A
DEV
QS
G
FA
RTG
K
LFA
MDHYADK
PDL
M
T
M
AK
S
L
A
GG
-
MPL
S
G
VV
G
N
A
N
I
M
D
A
PA
PG
G
--
---L
G
G
T
YA
GNPLA
V
AAA
H
A
V
L
NIIDKESLC
E
RAMQLGQ
RL
T
K
T
L
ID
A
K
E
NVPAIA
A
VRGLG
fig|478008.5.peg.3563
Escherichia coli O157:H7 str. EC869 (28-351/421)
S
AE
N
AT
L
K
D
V
EG
NE
Y
I
D
FAA
GI
AVLNT
GH
R
HP
D
L
V
AAV
-
E
Q
Q
LQQFT
H
TAYQIVPY
E
SY
V
T
L
A
E
K
I
NALA
P
VSGQAK
T
AFFT
T
G
A
EA
V
E
N
A
V
K
I
AR
AHTG-----
-
R
PGV
I
A
F
S
G
G
F
HG
R
T
--------
YM
TM
A
L
TGKVAP
-
YKIGF
G
PF
P
G
S
VYHVPYPSDLHGISTQDSLDAIERLFKS
D
IEAKQV
AAII
F
EPV
-
QG
E
GG
FNVAP
K
E
L
V
AA
I
R
R
LCDE
H
GI
V
M
I
A
DEV
QS
G
FA
RTG
K
LFA
MDHYADK
PDL
M
T
M
AK
S
L
A
GG
-
MPL
S
G
VV
G
N
A
N
I
M
D
A
PA
PG
G
--
---L
G
G
T
YA
GNPLA
V
AAA
H
A
V
L
NIIDKESLC
E
RAMQLGQ
RL
T
K
T
L
ID
A
K
E
NVPAIA
A
VRGLG
fig|637388.3.peg.1367
Escherichia coli O157:H7 str. FRIK2000 (28-351/421)
S
AE
N
AT
L
K
D
V
EG
NE
Y
I
D
FAA
GI
AVLNT
GH
R
HP
D
L
V
AAV
-
E
Q
Q
LQQFT
H
TAYQIVPY
E
SY
V
T
L
A
E
K
I
NALA
P
VSGQAK
T
AFFT
T
G
A
EA
V
E
N
A
V
K
I
AR
AHTG-----
-
R
PGV
I
A
F
S
G
G
F
HG
R
T
--------
YM
TM
A
L
TGKVAP
-
YKIGF
G
PF
P
G
S
VYHVPYPSDLHGISTQDSLDAIERLFKS
D
IEAKQV
AAII
F
EPV
-
QG
E
GG
FNVAP
K
E
L
V
AA
I
R
R
LCDE
H
GI
V
M
I
A
DEV
QS
G
FA
RTG
K
LFA
MDHYADK
PDL
M
T
M
AK
S
L
A
GG
-
MPL
S
G
VV
G
N
A
N
I
M
D
A
PA
PG
G
--
---L
G
G
T
YA
GNPLA
V
AAA
H
A
V
L
NIIDKESLC
E
RAMQLGQ
RL
T
K
T
L
ID
A
K
E
NVPAIA
A
VRGLG
fig|570506.3.peg.3346
Escherichia coli O157:H7 str. FRIK966 (28-351/421)
S
AE
N
AT
L
K
D
V
EG
NE
Y
I
D
FAA
GI
AVLNT
GH
R
HP
D
L
V
AAV
-
E
Q
Q
LQQFT
H
TAYQIVPY
E
SY
V
T
L
A
E
K
I
NALA
P
VSGQAK
T
AFFT
T
G
A
EA
V
E
N
A
V
K
I
AR
AHTG-----
-
R
PGV
I
A
F
S
G
G
F
HG
R
T
--------
YM
TM
A
L
TGKVAP
-
YKIGF
G
PF
P
G
S
VYHVPYPSDLHGISTQDSLDAIERLFKS
D
IEAKQV
AAII
F
EPV
-
QG
E
GG
FNVAP
K
E
L
V
AA
I
R
R
LCDE
H
GI
V
M
I
A
DEV
QS
G
FA
RTG
K
LFA
MDHYADK
PDL
M
T
M
AK
S
L
A
GG
-
MPL
S
G
VV
G
N
A
N
I
M
D
A
PA
PG
G
--
---L
G
G
T
YA
GNPLA
V
AAA
H
A
V
L
NIIDKESLC
E
RAMQLGQ
RL
T
K
T
L
ID
A
K
E
NVPAIA
A
VRGLG
fig|386585.9.peg.1983
Escherichia coli O157:H7 str. Sakai (28-351/421)
S
AE
N
AT
L
K
D
V
EG
NE
Y
I
D
FAA
GI
AVLNT
GH
R
HP
D
L
V
AAV
-
E
Q
Q
LQQFT
H
TAYQIVPY
E
SY
V
T
L
A
E
K
I
NALA
P
VSGQAK
T
AFFT
T
G
A
EA
V
E
N
A
V
K
I
AR
AHTG-----
-
R
PGV
I
A
F
S
G
G
F
HG
R
T
--------
YM
TM
A
L
TGKVAP
-
YKIGF
G
PF
P
G
S
VYHVPYPSDLHGISTQDSLDAIERLFKS
D
IEAKQV
AAII
F
EPV
-
QG
E
GG
FNVAP
K
E
L
V
AA
I
R
R
LCDE
H
GI
V
M
I
A
DEV
QS
G
FA
RTG
K
LFA
MDHYADK
PDL
M
T
M
AK
S
L
A
GG
-
MPL
S
G
VV
G
N
A
N
I
M
D
A
PA
PG
G
--
---L
G
G
T
YA
GNPLA
V
AAA
H
A
V
L
NIIDKESLC
E
RAMQLGQ
RL
T
K
T
L
ID
A
K
E
NVPAIA
A
VRGLG
fig|544404.4.peg.1856
Escherichia coli O157:H7 str. TW14359 (28-351/421)
S
AE
N
AT
L
K
D
V
EG
NE
Y
I
D
FAA
GI
AVLNT
GH
R
HP
D
L
V
AAV
-
E
Q
Q
LQQFT
H
TAYQIVPY
E
SY
V
T
L
A
E
K
I
NALA
P
VSGQAK
T
AFFT
T
G
A
EA
V
E
N
A
V
K
I
AR
AHTG-----
-
R
PGV
I
A
F
S
G
G
F
HG
R
T
--------
YM
TM
A
L
TGKVAP
-
YKIGF
G
PF
P
G
S
VYHVPYPSDLHGISTQDSLDAIERLFKS
D
IEAKQV
AAII
F
EPV
-
QG
E
GG
FNVAP
K
E
L
V
AA
I
R
R
LCDE
H
GI
V
M
I
A
DEV
QS
G
FA
RTG
K
LFA
MDHYADK
PDL
M
T
M
AK
S
L
A
GG
-
MPL
S
G
VV
G
N
A
N
I
M
D
A
PA
PG
G
--
---L
G
G
T
YA
GNPLA
V
AAA
H
A
V
L
NIIDKESLC
E
RAMQLGQ
RL
T
K
T
L
ID
A
K
E
NVPAIA
A
VRGLG
fig|502346.5.peg.5495
Escherichia coli O157:H7 str. TW14588 (28-351/421)
S
AE
N
AT
L
K
D
V
EG
NE
Y
I
D
FAA
GI
AVLNT
GH
R
HP
D
L
V
AAV
-
E
Q
Q
LQQFT
H
TAYQIVPY
E
SY
V
T
L
A
E
K
I
NALA
P
VSGQAK
T
AFFT
T
G
A
EA
V
E
N
A
V
K
I
AR
AHTG-----
-
R
PGV
I
A
F
S
G
G
F
HG
R
T
--------
YM
TM
A
L
TGKVAP
-
YKIGF
G
PF
P
G
S
VYHVPYPSDLHGISTQDSLDAIERLFKS
D
IEAKQV
AAII
F
EPV
-
QG
E
GG
FNVAP
K
E
L
V
AA
I
R
R
LCDE
H
GI
V
M
I
A
DEV
QS
G
FA
RTG
K
LFA
MDHYADK
PDL
M
T
M
AK
S
L
A
GG
-
MPL
S
G
VV
G
N
A
N
I
M
D
A
PA
PG
G
--
---L
G
G
T
YA
GNPLA
V
AAA
H
A
V
L
NIIDKESLC
E
RAMQLGQ
RL
T
K
T
L
ID
A
K
E
NVPAIA
A
VRGLG
fig|701177.3.peg.1641
Escherichia coli O55:H7 str. CB9615 (28-351/421)
S
AE
N
AT
L
K
D
V
EG
NE
Y
I
D
FAA
GI
AVLNT
GH
R
HP
D
L
V
AAV
-
E
Q
Q
LQQFT
H
TAYQIVPY
E
SY
V
T
L
A
E
K
I
NALA
P
VSGQAK
T
AFFT
T
G
A
EA
V
E
N
A
V
K
I
AR
AHTG-----
-
R
PGV
I
A
F
S
G
G
F
HG
R
T
--------
YM
TM
A
L
TGKVAP
-
YKIGF
G
PF
P
G
S
VYHVPYPSDLHGISTQDSLDAIERLFKS
D
IEAKQV
AAII
F
EPV
-
QG
E
GG
FNVAP
K
E
L
V
AA
I
R
R
LCDE
H
GI
V
M
I
A
DEV
QS
G
FA
RTG
K
LFA
MDHYADK
PDL
M
T
M
AK
S
L
A
GG
-
MPL
S
G
VV
G
N
A
N
I
M
D
A
PA
PG
G
--
---L
G
G
T
YA
GNPLA
V
AAA
H
A
V
L
NIIDKESLC
E
RAMQLGQ
RL
T
K
T
L
ID
A
K
E
NVPAIA
A
VRGLG
fig|656414.3.peg.1569
Escherichia coli H736 (28-351/421)
S
AE
N
AT
L
K
D
V
EG
NE
Y
I
D
FAA
GI
AVLNT
GH
R
HP
D
L
V
AAV
-
E
Q
Q
LQQFT
H
TAYQIVPY
E
SY
V
T
L
A
E
K
I
NALA
P
VSGQAK
T
AFFT
T
G
A
EA
V
E
N
A
V
K
I
AR
AHTG-----
-
R
PGV
I
A
F
S
G
G
F
HG
R
T
--------
YM
TM
A
L
TGKVAP
-
YKIGF
G
PF
P
G
S
VYHVPYPSDLHGISTQDSLDAIERLFKS
D
IEAKQV
AAII
F
EPV
-
QG
E
GG
FNVAP
K
E
L
V
AA
I
R
R
LCDE
H
GI
V
M
I
A
DEV
QS
G
FA
RTG
K
LFA
MDHYADK
PDL
M
T
M
AK
S
L
A
GG
-
MPL
S
G
VV
G
N
A
N
I
M
D
A
PA
PG
G
--
---L
G
G
T
YA
GNPLA
V
AAA
H
A
V
L
NIIDKESLC
E
RANQLGQ
RL
T
N
T
L
ID
A
K
E
SVPAIA
A
VRGLG
fig|749540.3.peg.3574
Escherichia coli MS 146-1 (28-351/421)
S
AE
N
AT
L
K
D
V
EG
NE
Y
I
D
FAA
GI
AVLNT
GH
R
HP
D
L
V
AAV
-
E
Q
Q
LQQFT
H
TAYQIVPY
E
SY
V
T
L
A
E
K
I
NALA
P
VSGQAK
T
AFFT
T
G
A
EA
V
E
N
A
V
K
I
AR
AHTG-----
-
R
PGV
I
A
F
S
G
G
F
HG
R
T
--------
YM
TM
A
L
TGKVAP
-
YKIGF
G
PF
P
G
S
VYHVPYPSDLHGISTQDSLDAIERLFKS
D
IEAKQV
AAII
F
EPV
-
QG
E
GG
FNVAP
K
E
L
V
AA
I
R
R
LCDE
H
GI
V
M
I
A
DEV
QS
G
FA
RTG
K
LFA
MDHYADK
PDL
M
T
M
AK
S
L
A
GG
-
MPL
S
G
VV
G
N
A
N
I
M
D
A
PA
PG
G
--
---L
G
G
T
YA
GNPLA
V
AAA
H
A
V
L
NIIDKESLC
E
RANQLGQ
RL
T
N
T
L
ID
A
K
E
SVPAIA
A
VRGLG
fig|679205.4.peg.2838
Escherichia coli MS 124-1 (28-351/421)
S
AE
N
AT
L
K
D
V
EG
NE
Y
I
D
FAA
GI
AVLNT
GH
R
HP
D
L
V
AAV
-
E
Q
Q
LQQFT
H
TAYQIVPY
E
SY
V
T
L
A
E
K
I
NALA
P
VSGQAK
T
AFFT
T
G
A
EA
V
E
N
A
V
K
I
AR
AHTG-----
-
R
PGV
I
A
F
S
G
G
F
HG
R
T
--------
YM
TM
A
L
TGKVAP
-
YKIGF
G
PF
P
G
S
VYHVPYPSDLHGISTQDSLDAIERLFKS
D
IEAKQV
AAII
F
EPV
-
QG
E
GG
FNVAP
K
E
L
V
AA
I
R
R
LCDE
H
GI
V
M
I
A
DEV
QS
G
FA
RTG
K
LFA
MDHYADK
PDL
M
T
M
AK
S
L
A
GG
-
MPL
S
G
VV
G
N
A
N
I
M
D
A
PA
PG
G
--
---L
G
G
T
YA
GNPLA
V
AAA
H
A
V
L
NIIDKESLC
E
RANQLGQ
RL
T
N
T
L
ID
A
K
E
SVPAIA
A
VRGLG
fig|749533.3.peg.2866
Escherichia coli MS 84-1 (28-351/421)
S
AE
N
AT
L
K
D
V
EG
NE
Y
I
D
FAA
GI
AVLNT
GH
R
HP
D
L
V
AAV
-
E
Q
Q
LQQFT
H
TAYQIVPY
E
SY
V
T
L
A
E
K
I
NALA
P
VSGQAK
T
AFFT
T
G
A
EA
V
E
N
A
V
K
I
AR
AHTG-----
-
R
PGV
I
A
F
S
G
G
F
HG
R
T
--------
YM
TM
A
L
TGKVAP
-
YKIGF
G
PF
P
G
S
VYHVPYPSDLHGISTQDSLDAIERLFKS
D
IEAKQV
AAII
F
EPV
-
QG
E
GG
FNVAP
K
E
L
V
AA
I
R
R
LCDE
H
GI
V
M
I
A
DEV
QS
G
FA
RTG
K
LFA
MDHYADK
PDL
M
T
M
AK
S
L
A
GG
-
MPL
S
G
VV
G
N
A
N
I
M
D
A
PA
PG
G
--
---L
G
G
T
YA
GNPLA
V
AAA
H
A
V
L
NIIDKESLC
E
RANQLGQ
RL
T
N
T
L
ID
A
K
E
SVPAIA
A
VRGLG
fig|749527.3.peg.426
Escherichia coli MS 21-1 (28-351/421)
S
AE
N
AM
L
K
D
V
EG
NE
Y
I
D
FAA
GI
AVLNT
GH
R
HP
D
L
V
AAV
-
E
Q
Q
LQQFT
H
TAYQIVPY
E
SY
V
T
L
A
E
K
I
NALA
P
VSGQAK
T
AFFT
T
G
A
EA
V
E
N
A
V
K
I
AR
AHTG-----
-
R
PGV
I
A
F
S
G
G
F
HG
R
T
--------
YM
TM
A
L
TGKVAP
-
YKIGF
G
PF
P
G
S
VYHVPYPSDLHGVSTQDSLDAIERLFKS
D
IEAKQV
AAII
F
EPV
-
QG
E
GG
FNVAP
K
E
L
V
AA
I
R
R
LCDE
H
GI
V
M
I
A
DEV
QS
G
FA
RTG
K
LFA
MDHYADK
PDL
M
T
M
AK
S
L
A
GG
-
MPL
S
G
VV
G
N
A
N
I
M
D
A
PA
PG
G
--
---L
G
G
T
YA
GNPLA
V
AAA
H
A
V
L
NIIDKESLC
E
RANQLGQ
RL
T
N
T
L
ID
A
K
E
SVPAIA
A
VRGLG
fig|439855.10.peg.1976
Escherichia coli SMS-3-5 (28-351/421)
S
AE
N
AM
L
K
D
V
EG
NE
Y
I
D
FAA
GI
AVLNT
GH
R
HP
D
L
V
AAV
-
E
Q
Q
LQQFT
H
TAYQIVPY
E
SY
V
T
L
A
E
K
I
NALA
P
VSGQAK
T
AFFT
T
G
A
EA
V
E
N
A
V
K
I
AR
AHTG-----
-
R
PGV
I
A
F
S
G
G
F
HG
R
T
--------
YM
TM
A
L
TGKVAP
-
YKIGF
G
PF
P
G
S
VYHVPYPSDLHGVSTQDSLDAIERLFKS
D
IEAKQV
AAII
F
EPV
-
QG
E
GG
FNVAP
K
E
L
V
AA
I
R
R
LCDE
H
GI
V
M
I
A
DEV
QS
G
FA
RTG
K
LFA
MDHYADK
PDL
M
T
M
AK
S
L
A
GG
-
MPL
S
G
VV
G
N
A
N
I
M
D
A
PA
PG
G
--
---L
G
G
T
YA
GNPLA
V
AAA
H
A
V
L
NIIDKESLC
E
RANQLGQ
RL
T
N
T
L
ID
A
K
E
SVPAIA
A
VRGLG
fig|656379.3.peg.3397
Escherichia coli FVEC1302 (28-351/421)
S
AE
N
AT
L
K
D
V
EG
NE
Y
I
D
FAA
GI
AVLNT
GH
R
HP
D
L
V
AAV
-
E
Q
Q
LQQFT
H
TAYQIVPY
E
SY
V
T
L
A
E
K
I
NALA
P
VSGQAK
T
AFFT
T
G
A
EA
V
E
N
A
V
K
I
AR
AHTG-----
-
R
PGV
I
A
F
S
G
G
F
HG
R
T
--------
YM
TM
A
L
TGKVAP
-
YKIGF
G
PF
P
G
S
VYHVPYPSDLHGVSTQDSLDTIERLFKS
D
IEAKQV
AAII
F
EPV
-
QG
E
GG
FNVAP
K
E
L
V
AA
I
R
R
LCDE
H
GI
V
M
I
A
DEV
QS
G
FA
RTG
K
LFA
MDHYADK
PDL
M
T
M
AK
S
L
A
GG
-
MPL
S
G
VV
G
N
A
N
I
M
D
A
PA
PG
G
--
---L
G
G
T
YA
GNPLA
V
AAA
H
A
V
L
NIIDKESLC
E
RANQLGQ
RL
T
N
T
L
ID
A
K
E
SVPAIA
A
VRGLG
fig|656380.3.peg.2750
Escherichia coli FVEC1412 (28-351/421)
S
AE
N
AT
L
K
D
V
EG
NE
Y
I
D
FAA
GI
AVLNT
GH
R
HP
D
L
V
AAV
-
E
Q
Q
LQQFT
H
TAYQIVPY
E
SY
V
T
L
A
E
K
I
NALA
P
VSGQAK
T
AFFT
T
G
A
EA
V
E
N
A
V
K
I
AR
AHTG-----
-
R
PGV
I
A
F
S
G
G
F
HG
R
T
--------
YM
TM
A
L
TGKVAP
-
YKIGF
G
PF
P
G
S
VYHVPYPSDLHGVSTQDSLDTIERLFKS
D
IEAKQV
AAII
F
EPV
-
QG
E
GG
FNVAP
K
E
L
V
AA
I
R
R
LCDE
H
GI
V
M
I
A
DEV
QS
G
FA
RTG
K
LFA
MDHYADK
PDL
M
T
M
AK
S
L
A
GG
-
MPL
S
G
VV
G
N
A
N
I
M
D
A
PA
PG
G
--
---L
G
G
T
YA
GNPLA
V
AAA
H
A
V
L
NIIDKESLC
E
RANQLGQ
RL
T
N
T
L
ID
A
K
E
SVPAIA
A
VRGLG
fig|749549.3.peg.1509
Escherichia coli MS 198-1 (28-351/421)
S
AE
N
AT
L
K
D
V
EG
NE
Y
I
D
FAA
GI
AVLNT
GH
R
HP
D
L
V
AAV
-
E
Q
Q
LQQFT
H
TAYQIVPY
E
SY
V
T
L
A
E
K
I
NALA
P
VSGQAK
T
AFFT
T
G
A
EA
V
E
N
A
V
K
I
AR
AHTG-----
-
R
PGV
I
A
F
S
G
G
F
HG
R
T
--------
YM
TM
A
L
TGKVAP
-
YKIGF
G
PF
P
G
S
VYHVPYPSDLHGVSTQDSLDTIERLFKS
D
IEAKQV
AAII
F
EPV
-
QG
E
GG
FNVAP
K
E
L
V
AA
I
R
R
LCDE
H
GI
V
M
I
A
DEV
QS
G
FA
RTG
K
LFA
MDHYADK
PDL
M
T
M
AK
S
L
A
GG
-
MPL
S
G
VV
G
N
A
N
I
M
D
A
PA
PG
G
--
---L
G
G
T
YA
GNPLA
V
AAA
H
A
V
L
NIIDKESLC
E
RANQLGQ
RL
T
N
T
L
ID
A
K
E
SVPAIA
A
VRGLG
fig|585056.7.peg.1801
Escherichia coli UMN026 (28-351/421)
S
AE
N
AT
L
K
D
V
EG
NE
Y
I
D
FAA
GI
AVLNT
GH
R
HP
D
L
V
AAV
-
E
Q
Q
LQQFT
H
TAYQIVPY
E
SY
V
T
L
A
E
K
I
NALA
P
VSGQAK
T
AFFT
T
G
A
EA
V
E
N
A
V
K
I
AR
AHTG-----
-
R
PGV
I
A
F
S
G
G
F
HG
R
T
--------
YM
TM
A
L
TGKVAP
-
YKIGF
G
PF
P
G
S
VYHVPYPSDLHGVSTQDSLDTIERLFKS
D
IEAKQV
AAII
F
EPV
-
QG
E
GG
FNVAP
K
E
L
V
AA
I
R
R
LCDE
H
GI
V
M
I
A
DEV
QS
G
FA
RTG
K
LFA
MDHYADK
PDL
M
T
M
AK
S
L
A
GG
-
MPL
S
G
VV
G
N
A
N
I
M
D
A
PA
PG
G
--
---L
G
G
T
YA
GNPLA
V
AAA
H
A
V
L
NIIDKESLC
E
RANQLGQ
RL
T
N
T
L
ID
A
K
E
SVPAIA
A
VRGLG
fig|550676.3.peg.864
Escherichia coli B185 (28-351/421)
S
AE
N
AT
L
K
D
V
EG
NE
Y
I
D
FAA
GI
AVLNT
GH
R
HP
D
L
V
AAV
-
E
Q
Q
LQQFT
H
TAYQIVPY
E
SY
V
T
L
A
E
K
I
NALA
P
VSGQAK
T
AFFT
T
G
A
EA
V
E
N
A
V
K
I
AR
AHTG-----
-
R
PGV
I
A
F
S
G
G
F
HG
R
T
--------
YM
TM
A
L
TGKVAP
-
YKIGF
G
PF
P
G
S
VYHVPYPSDLHDVSTQDSLDAIERLFKS
D
IEAKQV
AAII
F
EPV
-
QG
E
GG
FNVAP
K
E
L
V
AA
I
R
R
LCDE
H
GI
V
M
I
A
DEV
QS
G
FA
RTG
K
LFA
MDHYADK
PDL
M
T
M
AK
S
L
A
GG
-
MPL
S
G
VV
G
N
A
N
I
M
D
A
PA
PG
G
--
---L
G
G
T
YA
GNPLA
V
AAA
H
A
V
L
NIIDKESLC
E
RANQLGQ
RL
T
N
T
L
ID
A
K
E
SVPAIA
A
VRGLG
fig|585057.4.peg.1727
Escherichia coli IAI39 (28-351/421)
S
AE
N
AT
L
K
D
V
EG
NE
Y
I
D
FAA
GI
AVLNT
GH
R
HP
D
L
V
AAV
-
E
Q
Q
LQQFT
H
TAYQIVPY
E
SY
V
T
L
A
E
K
I
NALA
P
VSGQAK
T
AFFT
T
G
A
EA
V
E
N
A
V
K
I
AR
AHTG-----
-
R
PGV
I
A
F
S
G
G
F
HG
R
T
--------
YM
TM
A
L
TGKVAP
-
YKIGF
G
PF
P
G
S
VYHVPYPSDLHDVSTQDSLDAIERLFKS
D
IEAKQV
AAII
F
EPV
-
QG
E
GG
FNVAP
K
E
L
V
AA
I
R
R
LCDE
H
GI
V
M
I
A
DEV
QS
G
FA
RTG
K
LFA
MDHYADK
PDL
M
T
M
AK
S
L
A
GG
-
MPL
S
G
VV
G
N
A
N
I
M
D
A
PA
PG
G
--
---L
G
G
T
YA
GNPLA
V
AAA
H
A
V
L
NIIDKESLC
E
RANQLGQ
RL
T
N
T
L
ID
A
K
E
SVPAIA
A
VRGLG
fig|585057.6.peg.1727
Escherichia coli IAI39 (28-351/421)
S
AE
N
AT
L
K
D
V
EG
NE
Y
I
D
FAA
GI
AVLNT
GH
R
HP
D
L
V
AAV
-
E
Q
Q
LQQFT
H
TAYQIVPY
E
SY
V
T
L
A
E
K
I
NALA
P
VSGQAK
T
AFFT
T
G
A
EA
V
E
N
A
V
K
I
AR
AHTG-----
-
R
PGV
I
A
F
S
G
G
F
HG
R
T
--------
YM
TM
A
L
TGKVAP
-
YKIGF
G
PF
P
G
S
VYHVPYPSDLHDVSTQDSLDAIERLFKS
D
IEAKQV
AAII
F
EPV
-
QG
E
GG
FNVAP
K
E
L
V
AA
I
R
R
LCDE
H
GI
V
M
I
A
DEV
QS
G
FA
RTG
K
LFA
MDHYADK
PDL
M
T
M
AK
S
L
A
GG
-
MPL
S
G
VV
G
N
A
N
I
M
D
A
PA
PG
G
--
---L
G
G
T
YA
GNPLA
V
AAA
H
A
V
L
NIIDKESLC
E
RANQLGQ
RL
T
N
T
L
ID
A
K
E
SVPAIA
A
VRGLG
fig|656393.3.peg.2078
Escherichia coli H299 (28-351/421)
S
AE
N
AM
L
K
D
V
EG
NE
Y
I
D
FAA
GI
AVLNT
GH
R
HP
D
L
V
AAV
-
E
Q
Q
LQQFT
H
TAYQIVPY
E
SY
V
T
L
A
E
K
I
NALA
P
VSGQAK
T
AFFT
T
G
A
EA
V
E
N
A
V
K
I
AR
AHTG-----
-
R
PGV
I
A
F
S
G
G
F
HG
R
T
--------
YM
TM
A
L
TGKVAP
-
YKIGF
G
PF
P
G
S
VYHVPYPSDLHDVSTQDSLDAIERLFKS
D
IEAKQV
AAII
F
EPV
-
QG
E
GG
FNVAP
K
E
L
V
AA
I
R
R
LCDE
H
GI
V
M
I
A
DEV
QS
G
FA
RTG
K
LFA
MDHYADK
PDL
M
T
M
AK
S
L
A
GG
-
MPL
S
G
VV
G
N
A
N
I
M
D
A
PA
PG
G
--
---L
G
G
T
YA
GNPLA
V
AAA
H
A
V
L
NIIDKESLC
E
RANQLGQ
RL
T
N
T
L
ID
A
K
E
SVPAIA
A
VRGLG
fig|585055.6.peg.1494
Escherichia coli 55989 (28-351/421)
S
AE
N
AT
L
K
D
V
EG
NE
Y
I
D
FAA
GI
AVLNT
GH
R
HP
E
L
V
AAV
-
E
Q
Q
LQQFT
H
TAYQIVPY
E
SY
V
T
L
A
E
K
I
NALA
P
VSGQAK
T
AFFT
T
G
A
EA
V
E
N
A
V
K
I
AR
AHTG-----
-
R
PGV
I
A
F
S
G
G
F
HG
R
T
--------
YM
TM
A
L
TGKVAP
-
YKIGF
G
PF
P
G
S
VYHVPYPSDLHGISTQDSLDAIERLFKS
D
IEAKQV
AAII
F
EPV
-
QG
E
GG
FNVAP
K
E
L
V
AA
I
R
R
LCDE
H
GI
V
M
I
A
DEV
QS
G
FA
RTG
K
LFA
MDHYVDK
PDL
M
T
M
AK
S
L
A
GG
-
MPL
S
G
VV
G
N
A
N
I
M
D
A
PA
PG
G
--
---L
G
G
T
YA
GNPLA
V
AAA
P
A
V
L
NIIDKESLC
E
RANQLGQ
RL
K
N
T
L
ID
A
K
E
SVPAIA
A
VRGLG
fig|585055.8.peg.1495
Escherichia coli 55989 (28-351/421)
S
AE
N
AT
L
K
D
V
EG
NE
Y
I
D
FAA
GI
AVLNT
GH
R
HP
E
L
V
AAV
-
E
Q
Q
LQQFT
H
TAYQIVPY
E
SY
V
T
L
A
E
K
I
NALA
P
VSGQAK
T
AFFT
T
G
A
EA
V
E
N
A
V
K
I
AR
AHTG-----
-
R
PGV
I
A
F
S
G
G
F
HG
R
T
--------
YM
TM
A
L
TGKVAP
-
YKIGF
G
PF
P
G
S
VYHVPYPSDLHGISTQDSLDAIERLFKS
D
IEAKQV
AAII
F
EPV
-
QG
E
GG
FNVAP
K
E
L
V
AA
I
R
R
LCDE
H
GI
V
M
I
A
DEV
QS
G
FA
RTG
K
LFA
MDHYVDK
PDL
M
T
M
AK
S
L
A
GG
-
MPL
S
G
VV
G
N
A
N
I
M
D
A
PA
PG
G
--
---L
G
G
T
YA
GNPLA
V
AAA
P
A
V
L
NIIDKESLC
E
RANQLGQ
RL
K
N
T
L
ID
A
K
E
SVPAIA
A
VRGLG
fig|595496.3.peg.160
Escherichia coli BW2952 (36-340/426)
IEK
A
D
G
AY
L
Y
D
V
D
G
KA
Y
I
D
YVG
SW
GPMVL
GH
N
HP
A
I
R
N
AV
I
E
A
A
ERGLS
F
GA----PT
E
ME
V
K
M
A
Q
L
V
TELV
P
TM--DM
V
RMVN
SG
T
EA
T
M
S
A
I
R
LAR
GFTG-----
-
R
DKI
I
K
F
E
G
C
YHG
H
A
DCLLVKAG
SG
A
LT
L
GQPNSP
-
-----
-
GV
P
A
D
FAKYTLTC------TYNDLASVRAAFE-
-
QYPQEI
A
C
II
V
EPV
-
A
G
N
MN
CVPPL
PE
F
L
PG
LR
A
LCDE
F
G
A
LLI
I
DEV
MT
G
F-
R
VA
L
AG
A
QDYYGVV
PDL
T
C
L
G
K
I
I
G
GG
-
MP
V
G
A
FG
G
R
R
D
VM
D
A
LA
P
T
G
--
PVYQ
A
G
T
LS
GNP
I
A
M
AA
G
F
A
C
L
NEVAQPGVH
E
TLDELTT
RL
A
E
G
L
LE
A
A
E
fig|536056.3.peg.3643
Escherichia coli DH1 (36-340/426)
IEK
A
D
G
AY
L
Y
D
V
D
G
KA
Y
I
D
YVG
SW
GPMVL
GH
N
HP
A
I
R
N
AV
I
E
A
A
ERGLS
F
GA----PT
E
ME
V
K
M
A
Q
L
V
TELV
P
TM--DM
V
RMVN
SG
T
EA
T
M
S
A
I
R
LAR
GFTG-----
-
R
DKI
I
K
F
E
G
C
YHG
H
A
DCLLVKAG
SG
A
LT
L
GQPNSP
-
-----
-
GV
P
A
D
FAKYTLTC------TYNDLASVRAAFE-
-
QYPQEI
A
C
II
V
EPV
-
A
G
N
MN
CVPPL
PE
F
L
PG
LR
A
LCDE
F
G
A
LLI
I
DEV
MT
G
F-
R
VA
L
AG
A
QDYYGVV
PDL
T
C
L
G
K
I
I
G
GG
-
MP
V
G
A
FG
G
R
R
D
VM
D
A
LA
P
T
G
--
PVYQ
A
G
T
LS
GNP
I
A
M
AA
G
F
A
C
L
NEVAQPGVH
E
TLDELTT
RL
A
E
G
L
LE
A
A
E
fig|83333.1.peg.155
Escherichia coli K12 (36-340/426)
IEK
A
D
G
AY
L
Y
D
V
D
G
KA
Y
I
D
YVG
SW
GPMVL
GH
N
HP
A
I
R
N
AV
I
E
A
A
ERGLS
F
GA----PT
E
ME
V
K
M
A
Q
L
V
TELV
P
TM--DM
V
RMVN
SG
T
EA
T
M
S
A
I
R
LAR
GFTG-----
-
R
DKI
I
K
F
E
G
C
YHG
H
A
DCLLVKAG
SG
A
LT
L
GQPNSP
-
-----
-
GV
P
A
D
FAKYTLTC------TYNDLASVRAAFE-
-
QYPQEI
A
C
II
V
EPV
-
A
G
N
MN
CVPPL
PE
F
L
PG
LR
A
LCDE
F
G
A
LLI
I
DEV
MT
G
F-
R
VA
L
AG
A
QDYYGVV
PDL
T
C
L
G
K
I
I
G
GG
-
MP
V
G
A
FG
G
R
R
D
VM
D
A
LA
P
T
G
--
PVYQ
A
G
T
LS
GNP
I
A
M
AA
G
F
A
C
L
NEVAQPGVH
E
TLDELTT
RL
A
E
G
L
LE
A
A
E
fig|316407.3.peg.151
Escherichia coli W3110 (36-340/426)
IEK
A
D
G
AY
L
Y
D
V
D
G
KA
Y
I
D
YVG
SW
GPMVL
GH
N
HP
A
I
R
N
AV
I
E
A
A
ERGLS
F
GA----PT
E
ME
V
K
M
A
Q
L
V
TELV
P
TM--DM
V
RMVN
SG
T
EA
T
M
S
A
I
R
LAR
GFTG-----
-
R
DKI
I
K
F
E
G
C
YHG
H
A
DCLLVKAG
SG
A
LT
L
GQPNSP
-
-----
-
GV
P
A
D
FAKYTLTC------TYNDLASVRAAFE-
-
QYPQEI
A
C
II
V
EPV
-
A
G
N
MN
CVPPL
PE
F
L
PG
LR
A
LCDE
F
G
A
LLI
I
DEV
MT
G
F-
R
VA
L
AG
A
QDYYGVV
PDL
T
C
L
G
K
I
I
G
GG
-
MP
V
G
A
FG
G
R
R
D
VM
D
A
LA
P
T
G
--
PVYQ
A
G
T
LS
GNP
I
A
M
AA
G
F
A
C
L
NEVAQPGVH
E
TLDELTT
RL
A
E
G
L
LE
A
A
E
fig|316385.5.peg.135
Escherichia coli str. K-12 substr. DH10B (36-340/426)
IEK
A
D
G
AY
L
Y
D
V
D
G
KA
Y
I
D
YVG
SW
GPMVL
GH
N
HP
A
I
R
N
AV
I
E
A
A
ERGLS
F
GA----PT
E
ME
V
K
M
A
Q
L
V
TELV
P
TM--DM
V
RMVN
SG
T
EA
T
M
S
A
I
R
LAR
GFTG-----
-
R
DKI
I
K
F
E
G
C
YHG
H
A
DCLLVKAG
SG
A
LT
L
GQPNSP
-
-----
-
GV
P
A
D
FAKYTLTC------TYNDLASVRAAFE-
-
QYPQEI
A
C
II
V
EPV
-
A
G
N
MN
CVPPL
PE
F
L
PG
LR
A
LCDE
F
G
A
LLI
I
DEV
MT
G
F-
R
VA
L
AG
A
QDYYGVV
PDL
T
C
L
G
K
I
I
G
GG
-
MP
V
G
A
FG
G
R
R
D
VM
D
A
LA
P
T
G
--
PVYQ
A
G
T
LS
GNP
I
A
M
AA
G
F
A
C
L
NEVAQPGVH
E
TLDELTT
RL
A
E
G
L
LE
A
A
E
fig|316385.7.peg.137
Escherichia coli str. K-12 substr. DH10B (36-340/426)
IEK
A
D
G
AY
L
Y
D
V
D
G
KA
Y
I
D
YVG
SW
GPMVL
GH
N
HP
A
I
R
N
AV
I
E
A
A
ERGLS
F
GA----PT
E
ME
V
K
M
A
Q
L
V
TELV
P
TM--DM
V
RMVN
SG
T
EA
T
M
S
A
I
R
LAR
GFTG-----
-
R
DKI
I
K
F
E
G
C
YHG
H
A
DCLLVKAG
SG
A
LT
L
GQPNSP
-
-----
-
GV
P
A
D
FAKYTLTC------TYNDLASVRAAFE-
-
QYPQEI
A
C
II
V
EPV
-
A
G
N
MN
CVPPL
PE
F
L
PG
LR
A
LCDE
F
G
A
LLI
I
DEV
MT
G
F-
R
VA
L
AG
A
QDYYGVV
PDL
T
C
L
G
K
I
I
G
GG
-
MP
V
G
A
FG
G
R
R
D
VM
D
A
LA
P
T
G
--
PVYQ
A
G
T
LS
GNP
I
A
M
AA
G
F
A
C
L
NEVAQPGVH
E
TLDELTT
RL
A
E
G
L
LE
A
A
E
fig|511145.12.peg.160
Escherichia coli str. K-12 substr. MG1655 (36-340/426)
IEK
A
D
G
AY
L
Y
D
V
D
G
KA
Y
I
D
YVG
SW
GPMVL
GH
N
HP
A
I
R
N
AV
I
E
A
A
ERGLS
F
GA----PT
E
ME
V
K
M
A
Q
L
V
TELV
P
TM--DM
V
RMVN
SG
T
EA
T
M
S
A
I
R
LAR
GFTG-----
-
R
DKI
I
K
F
E
G
C
YHG
H
A
DCLLVKAG
SG
A
LT
L
GQPNSP
-
-----
-
GV
P
A
D
FAKYTLTC------TYNDLASVRAAFE-
-
QYPQEI
A
C
II
V
EPV
-
A
G
N
MN
CVPPL
PE
F
L
PG
LR
A
LCDE
F
G
A
LLI
I
DEV
MT
G
F-
R
VA
L
AG
A
QDYYGVV
PDL
T
C
L
G
K
I
I
G
GG
-
MP
V
G
A
FG
G
R
R
D
VM
D
A
LA
P
T
G
--
PVYQ
A
G
T
LS
GNP
I
A
M
AA
G
F
A
C
L
NEVAQPGVH
E
TLDELTT
RL
A
E
G
L
LE
A
A
E
fig|511145.6.peg.159
Escherichia coli str. K-12 substr. MG1655 (36-340/426)
IEK
A
D
G
AY
L
Y
D
V
D
G
KA
Y
I
D
YVG
SW
GPMVL
GH
N
HP
A
I
R
N
AV
I
E
A
A
ERGLS
F
GA----PT
E
ME
V
K
M
A
Q
L
V
TELV
P
TM--DM
V
RMVN
SG
T
EA
T
M
S
A
I
R
LAR
GFTG-----
-
R
DKI
I
K
F
E
G
C
YHG
H
A
DCLLVKAG
SG
A
LT
L
GQPNSP
-
-----
-
GV
P
A
D
FAKYTLTC------TYNDLASVRAAFE-
-
QYPQEI
A
C
II
V
EPV
-
A
G
N
MN
CVPPL
PE
F
L
PG
LR
A
LCDE
F
G
A
LLI
I
DEV
MT
G
F-
R
VA
L
AG
A
QDYYGVV
PDL
T
C
L
G
K
I
I
G
GG
-
MP
V
G
A
FG
G
R
R
D
VM
D
A
LA
P
T
G
--
PVYQ
A
G
T
LS
GNP
I
A
M
AA
G
F
A
C
L
NEVAQPGVH
E
TLDELTT
RL
A
E
G
L
LE
A
A
E
fig|585057.4.peg.172
Escherichia coli IAI39 (36-340/426)
IEK
A
D
G
AY
L
Y
D
V
D
G
KA
Y
I
D
YVG
SW
GPMVL
GH
N
HP
A
I
R
N
AV
I
E
A
A
ERGLS
F
GA----PT
E
ME
V
K
M
A
Q
L
V
TELV
P
TM--DM
V
RMVN
SG
T
EA
T
M
S
A
I
R
LAR
GFTG-----
-
R
DKI
I
K
F
E
G
C
YHG
H
A
DCLLVKAG
SG
A
LT
L
GQPNSP
-
-----
-
GV
P
A
D
FAKHTLTC------TYNDLASVRAAFE-
-
QYPQEI
A
C
II
V
EPV
-
A
G
N
MN
CVPPL
PE
F
L
PG
LR
A
LCDE
F
G
A
LLI
I
DEV
MT
G
F-
R
VA
L
AG
A
QDYYGVV
PDL
T
C
L
G
K
I
I
G
GG
-
MP
V
G
A
FG
G
R
R
D
VM
D
A
LA
P
T
G
--
PVYQ
A
G
T
LS
GNP
I
A
M
AA
G
F
A
C
L
NEVAQPGVH
E
TLDELTT
RL
A
E
G
L
RE
A
A
E
fig|585057.6.peg.171
Escherichia coli IAI39 (36-340/426)
IEK
A
D
G
AY
L
Y
D
V
D
G
KA
Y
I
D
YVG
SW
GPMVL
GH
N
HP
A
I
R
N
AV
I
E
A
A
ERGLS
F
GA----PT
E
ME
V
K
M
A
Q
L
V
TELV
P
TM--DM
V
RMVN
SG
T
EA
T
M
S
A
I
R
LAR
GFTG-----
-
R
DKI
I
K
F
E
G
C
YHG
H
A
DCLLVKAG
SG
A
LT
L
GQPNSP
-
-----
-
GV
P
A
D
FAKHTLTC------TYNDLASVRAAFE-
-
QYPQEI
A
C
II
V
EPV
-
A
G
N
MN
CVPPL
PE
F
L
PG
LR
A
LCDE
F
G
A
LLI
I
DEV
MT
G
F-
R
VA
L
AG
A
QDYYGVV
PDL
T
C
L
G
K
I
I
G
GG
-
MP
V
G
A
FG
G
R
R
D
VM
D
A
LA
P
T
G
--
PVYQ
A
G
T
LS
GNP
I
A
M
AA
G
F
A
C
L
NEVAQPGVH
E
TLDELTT
RL
A
E
G
L
RE
A
A
E
fig|344610.3.peg.4059
Escherichia coli 53638 (36-340/426)
IEK
A
D
G
AY
L
Y
D
V
D
G
KA
Y
I
D
YVG
SW
GPMVL
GH
N
HP
A
I
R
N
AV
I
E
A
A
ERGLS
F
GA----PT
E
ME
V
K
M
A
Q
L
V
TELV
P
TM--DM
V
RMVN
SG
T
EA
T
M
S
A
I
R
LAR
GFTG-----
-
R
DKI
I
K
F
E
G
C
YHG
H
A
DCLLVKAG
SG
A
LT
L
GQPNSP
-
-----
-
GV
P
A
D
FAKHTLTC------TYNDLASVRAAFE-
-
QYPQEI
A
C
II
V
EPV
-
A
G
N
MN
CVPPL
PE
F
L
PG
LR
A
LCDE
F
G
A
LLI
I
DEV
MT
G
F-
R
VA
L
AG
A
QDYYGVV
PDL
T
C
L
G
K
I
I
G
GG
-
MP
V
G
A
FG
G
R
R
D
VM
D
A
LA
P
T
G
--
PVYQ
A
G
T
LS
GNP
I
A
M
AA
G
F
A
C
L
NEVAQPGVH
E
TLDELTT
RL
A
E
G
L
LE
A
A
E
fig|344610.7.peg.1577
Escherichia coli 53638 (36-340/426)
IEK
A
D
G
AY
L
Y
D
V
D
G
KA
Y
I
D
YVG
SW
GPMVL
GH
N
HP
A
I
R
N
AV
I
E
A
A
ERGLS
F
GA----PT
E
ME
V
K
M
A
Q
L
V
TELV
P
TM--DM
V
RMVN
SG
T
EA
T
M
S
A
I
R
LAR
GFTG-----
-
R
DKI
I
K
F
E
G
C
YHG
H
A
DCLLVKAG
SG
A
LT
L
GQPNSP
-
-----
-
GV
P
A
D
FAKHTLTC------TYNDLASVRAAFE-
-
QYPQEI
A
C
II
V
EPV
-
A
G
N
MN
CVPPL
PE
F
L
PG
LR
A
LCDE
F
G
A
LLI
I
DEV
MT
G
F-
R
VA
L
AG
A
QDYYGVV
PDL
T
C
L
G
K
I
I
G
GG
-
MP
V
G
A
FG
G
R
R
D
VM
D
A
LA
P
T
G
--
PVYQ
A
G
T
LS
GNP
I
A
M
AA
G
F
A
C
L
NEVAQPGVH
E
TLDELTT
RL
A
E
G
L
LE
A
A
E
fig|550677.3.peg.544
Escherichia coli B354 (36-340/426)
IEK
A
D
G
AY
L
Y
D
V
D
G
KA
Y
I
D
YVG
SW
GPMVL
GH
N
HP
A
I
R
N
AV
I
E
A
A
ERGLS
F
GA----PT
E
ME
V
K
M
A
Q
L
V
TELV
P
TM--DM
V
RMVN
SG
T
EA
T
M
S
A
I
R
LAR
GFTG-----
-
R
DKI
I
K
F
E
G
C
YHG
H
A
DCLLVKAG
SG
A
LT
L
GQPNSP
-
-----
-
GV
P
A
D
FAKHTLTC------TYNDLASVRAAFE-
-
QYPQEI
A
C
II
V
EPV
-
A
G
N
MN
CVPPL
PE
F
L
PG
LR
A
LCDE
F
G
A
LLI
I
DEV
MT
G
F-
R
VA
L
AG
A
QDYYGVE
PDL
T
C
L
G
K
I
I
G
GG
-
MP
V
G
A
FG
G
R
R
D
VM
D
A
LA
P
T
G
--
PIYQ
A
G
T
LS
GNP
I
A
M
AA
G
F
A
C
L
NEVAQPGVH
E
TLDELTT
RL
A
E
G
L
LE
A
A
E
fig|316401.4.peg.168
Escherichia coli ETEC H10407 (36-340/426)
IEK
A
D
G
AY
L
Y
D
V
D
G
KA
Y
I
D
YVG
SW
GPMVL
GH
N
HP
A
I
R
N
AV
I
E
A
A
ERGLS
F
GA----PT
E
ME
V
K
M
A
Q
L
V
TELV
P
TM--DM
V
RMVN
SG
T
EA
T
M
S
A
I
R
LAR
GFTG-----
-
R
DKI
I
K
F
E
G
C
YHG
H
A
DCLLVKAG
SG
A
LT
L
GQPNSP
-
-----
-
GV
P
A
D
FAKHTLTC------TYNDLASVRAAFE-
-
QYPQEI
A
C
II
V
EPV
-
A
G
N
MN
CVPPL
PE
F
L
PG
LR
A
LCDE
F
G
A
LLI
I
DEV
MT
G
F-
R
VA
L
AG
A
QDYYGVV
PDL
T
C
L
G
K
I
I
G
GG
-
MP
V
G
A
FG
G
R
R
D
VM
D
A
LA
P
T
G
--
PVYQ
A
G
T
LS
GNP
I
A
M
AA
G
F
A
C
L
NEVAQPGVH
E
TLDELTT
RL
A
E
G
L
LE
A
A
E
fig|656408.3.peg.5118
Escherichia coli H591 (36-340/426)
IEK
A
D
G
AY
L
Y
D
V
D
G
KA
Y
I
D
YVG
SW
GPMVL
GH
N
HP
A
I
R
N
AV
I
E
A
A
ERGLS
F
GA----PT
E
ME
V
K
M
A
Q
L
V
TELV
P
TM--DM
V
RMVN
SG
T
EA
T
M
S
A
I
R
LAR
GFTG-----
-
R
DKI
I
K
F
E
G
C
YHG
H
A
DCLLVKAG
SG
A
LT
L
GQPNSP
-
-----
-
GV
P
A
D
FAKHTLTC------TYNDLASVRAAFE-
-
QYPQEI
A
C
II
V
EPV
-
A
G
N
MN
CVPPL
PE
F
L
PG
LR
A
LCDE
F
G
A
LLI
I
DEV
MT
G
F-
R
VA
L
AG
A
QDYYGVV
PDL
T
C
L
G
K
I
I
G
GG
-
MP
V
G
A
FG
G
R
R
D
VM
D
A
LA
P
T
G
--
PVYQ
A
G
T
LS
GNP
I
A
M
AA
G
F
A
C
L
NEVAQPGVH
E
TLDELTT
RL
A
E
G
L
LE
A
A
E
fig|656414.3.peg.281
Escherichia coli H736 (36-340/426)
IEK
A
D
G
AY
L
Y
D
V
D
G
KA
Y
I
D
YVG
SW
GPMVL
GH
N
HP
A
I
R
N
AV
I
E
A
A
ERGLS
F
GA----PT
E
ME
V
K
M
A
Q
L
V
TELV
P
TM--DM
V
RMVN
SG
T
EA
T
M
S
A
I
R
LAR
GFTG-----
-
R
DKI
I
K
F
E
G
C
YHG
H
A
DCLLVKAG
SG
A
LT
L
GQPNSP
-
-----
-
GV
P
A
D
FAKHTLTC------TYNDLASVRAAFE-
-
QYPQEI
A
C
II
V
EPV
-
A
G
N
MN
CVPPL
PE
F
L
PG
LR
A
LCDE
F
G
A
LLI
I
DEV
MT
G
F-
R
VA
L
AG
A
QDYYGVV
PDL
T
C
L
G
K
I
I
G
GG
-
MP
V
G
A
FG
G
R
R
D
VM
D
A
LA
P
T
G
--
PVYQ
A
G
T
LS
GNP
I
A
M
AA
G
F
A
C
L
NEVAQPGVH
E
TLDELTT
RL
A
E
G
L
LE
A
A
E
fig|749537.3.peg.3258
Escherichia coli MS 115-1 (36-340/426)
IEK
A
D
G
AY
L
Y
D
V
D
G
KA
Y
I
D
YVG
SW
GPMVL
GH
N
HP
A
I
R
N
AV
I
E
A
A
ERGLS
F
GA----PT
E
ME
V
K
M
A
Q
L
V
TELV
P
TM--DM
V
RMVN
SG
T
EA
T
M
S
A
I
R
LAR
GFTG-----
-
R
DKI
I
K
F
E
G
C
YHG
H
A
DCLLVKAG
SG
A
LT
L
GQPNSP
-
-----
-
GV
P
A
D
FAKHTLTC------TYNDLASVRAAFE-
-
QYPQEI
A
C
II
V
EPV
-
A
G
N
MN
CVPPL
PE
F
L
PG
LR
A
LCDE
F
G
A
LLI
I
DEV
MT
G
F-
R
VA
L
AG
A
QDYYGVV
PDL
T
C
L
G
K
I
I
G
GG
-
MP
V
G
A
FG
G
R
R
D
VM
D
A
LA
P
T
G
--
PVYQ
A
G
T
LS
GNP
I
A
M
AA
G
F
A
C
L
NEVAQPGVH
E
TLDELTT
RL
A
E
G
L
LE
A
A
E
fig|749538.3.peg.3106
Escherichia coli MS 116-1 (36-340/426)
IEK
A
D
G
AY
L
Y
D
V
D
G
KA
Y
I
D
YVG
SW
GPMVL
GH
N
HP
A
I
R
N
AV
I
E
A
A
ERGLS
F
GA----PT
E
ME
V
K
M
A
Q
L
V
TELV
P
TM--DM
V
RMVN
SG
T
EA
T
M
S
A
I
R
LAR
GFTG-----
-
R
DKI
I
K
F
E
G
C
YHG
H
A
DCLLVKAG
SG
A
LT
L
GQPNSP
-
-----
-
GV
P
A
D
FAKHTLTC------TYNDLASVRAAFE-
-
QYPQEI
A
C
II
V
EPV
-
A
G
N
MN
CVPPL
PE
F
L
PG
LR
A
LCDE
F
G
A
LLI
I
DEV
MT
G
F-
R
VA
L
AG
A
QDYYGVV
PDL
T
C
L
G
K
I
I
G
GG
-
MP
V
G
A
FG
G
R
R
D
VM
D
A
LA
P
T
G
--
PVYQ
A
G
T
LS
GNP
I
A
M
AA
G
F
A
C
L
NEVAQPGVH
E
TLDELTT
RL
A
E
G
L
LE
A
A
E
fig|679206.4.peg.3881
Escherichia coli MS 119-7 (36-340/426)
IEK
A
D
G
AY
L
Y
D
V
D
G
KA
Y
I
D
YVG
SW
GPMVL
GH
N
HP
A
I
R
N
AV
I
E
A
A
ERGLS
F
GA----PT
E
ME
V
K
M
A
Q
L
V
TELV
P
TM--DM
V
RMVN
SG
T
EA
T
M
S
A
I
R
LAR
GFTG-----
-
R
DKI
I
K
F
E
G
C
YHG
H
A
DCLLVKAG
SG
A
LT
L
GQPNSP
-
-----
-
GV
P
A
D
FAKHTLTC------TYNDLASVRAAFE-
-
QYPQEI
A
C
II
V
EPV
-
A
G
N
MN
CVPPL
PE
F
L
PG
LR
A
LCDE
F
G
A
LLI
I
DEV
MT
G
F-
R
VA
L
AG
A
QDYYGVV
PDL
T
C
L
G
K
I
I
G
GG
-
MP
V
G
A
FG
G
R
R
D
VM
D
A
LA
P
T
G
--
PVYQ
A
G
T
LS
GNP
I
A
M
AA
G
F
A
C
L
NEVAQPGVH
E
TLDELTT
RL
A
E
G
L
LE
A
A
E
fig|749540.3.peg.2936
Escherichia coli MS 146-1 (36-340/426)
IEK
A
D
G
AY
L
Y
D
V
D
G
KA
Y
I
D
YVG
SW
GPMVL
GH
N
HP
A
I
R
N
AV
I
E
A
A
ERGLS
F
GA----PT
E
ME
V
K
M
A
Q
L
V
TELV
P
TM--DM
V
RMVN
SG
T
EA
T
M
S
A
I
R
LAR
GFTG-----
-
R
DKI
I
K
F
E
G
C
YHG
H
A
DCLLVKAG
SG
A
LT
L
GQPNSP
-
-----
-
GV
P
A
D
FAKHTLTC------TYNDLASVRAAFE-
-
QYPQEI
A
C
II
V
EPV
-
A
G
N
MN
CVPPL
PE
F
L
PG
LR
A
LCDE
F
G
A
LLI
I
DEV
MT
G
F-
R
VA
L
AG
A
QDYYGVV
PDL
T
C
L
G
K
I
I
G
GG
-
MP
V
G
A
FG
G
R
R
D
VM
D
A
LA
P
T
G
--
PVYQ
A
G
T
LS
GNP
I
A
M
AA
G
F
A
C
L
NEVAQPGVH
E
TLDELTT
RL
A
E
G
L
LE
A
A
E
fig|749544.3.peg.1804
Escherichia coli MS 175-1 (36-340/426)
IEK
A
D
G
AY
L
Y
D
V
D
G
KA
Y
I
D
YVG
SW
GPMVL
GH
N
HP
A
I
R
N
AV
I
E
A
A
ERGLS
F
GA----PT
E
ME
V
K
M
A
Q
L
V
TELV
P
TM--DM
V
RMVN
SG
T
EA
T
M
S
A
I
R
LAR
GFTG-----
-
R
DKI
I
K
F
E
G
C
YHG
H
A
DCLLVKAG
SG
A
LT
L
GQPNSP
-
-----
-
GV
P
A
D
FAKHTLTC------TYNDLASVRAAFE-
-
QYPQEI
A
C
II
V
EPV
-
A
G
N
MN
CVPPL
PE
F
L
PG
LR
A
LCDE
F
G
A
LLI
I
DEV
MT
G
F-
R
VA
L
AG
A
QDYYGVV
PDL
T
C
L
G
K
I
I
G
GG
-
MP
V
G
A
FG
G
R
R
D
VM
D
A
LA
P
T
G
--
PVYQ
A
G
T
LS
GNP
I
A
M
AA
G
F
A
C
L
NEVAQPGVH
E
TLDELTT
RL
A
E
G
L
LE
A
A
E
fig|749545.3.peg.1207
Escherichia coli MS 182-1 (36-340/426)
IEK
A
D
G
AY
L
Y
D
V
D
G
KA
Y
I
D
YVG
SW
GPMVL
GH
N
HP
A
I
R
N
AV
I
E
A
A
ERGLS
F
GA----PT
E
ME
V
K
M
A
Q
L
V
TELV
P
TM--DM
V
RMVN
SG
T
EA
T
M
S
A
I
R
LAR
GFTG-----
-
R
DKI
I
K
F
E
G
C
YHG
H
A
DCLLVKAG
SG
A
LT
L
GQPNSP
-
-----
-
GV
P
A
D
FAKHTLTC------TYNDLASVRAAFE-
-
QYPQEI
A
C
II
V
EPV
-
A
G
N
MN
CVPPL
PE
F
L
PG
LR
A
LCDE
F
G
A
LLI
I
DEV
MT
G
F-
R
VA
L
AG
A
QDYYGVV
PDL
T
C
L
G
K
I
I
G
GG
-
MP
V
G
A
FG
G
R
R
D
VM
D
A
LA
P
T
G
--
PVYQ
A
G
T
LS
GNP
I
A
M
AA
G
F
A
C
L
NEVAQPGVH
E
TLDELTT
RL
A
E
G
L
LE
A
A
E
fig|749527.3.peg.3262
Escherichia coli MS 21-1 (36-340/426)
IEK
A
D
G
AY
L
Y
D
V
D
G
KA
Y
I
D
YVG
SW
GPMVL
GH
N
HP
A
I
R
N
AV
I
E
A
A
ERGLS
F
GA----PT
E
ME
V
K
M
A
Q
L
V
TELV
P
TM--DM
V
RMVN
SG
T
EA
T
M
S
A
I
R
LAR
GFTG-----
-
R
DKI
I
K
F
E
G
C
YHG
H
A
DCLLVKAG
SG
A
LT
L
GQPNSP
-
-----
-
GV
P
A
D
FAKHTLTC------TYNDLASVRAAFE-
-
QYPQEI
A
C
II
V
EPV
-
A
G
N
MN
CVPPL
PE
F
L
PG
LR
A
LCDE
F
G
A
LLI
I
DEV
MT
G
F-
R
VA
L
AG
A
QDYYGVV
PDL
T
C
L
G
K
I
I
G
GG
-
MP
V
G
A
FG
G
R
R
D
VM
D
A
LA
P
T
G
--
PVYQ
A
G
T
LS
GNP
I
A
M
AA
G
F
A
C
L
NEVAQPGVH
E
TLDELTT
RL
A
E
G
L
LE
A
A
E
fig|749532.3.peg.4363
Escherichia coli MS 78-1 (36-340/426)
IEK
A
D
G
AY
L
Y
D
V
D
G
KA
Y
I
D
YVG
SW
GPMVL
GH
N
HP
A
I
R
N
AV
I
E
A
A
ERGLS
F
GA----PT
E
ME
V
K
M
A
Q
L
V
TELV
P
TM--DM
V
RMVN
SG
T
EA
T
M
S
A
I
R
LAR
GFTG-----
-
R
DKI
I
K
F
E
G
C
YHG
H
A
DCLLVKAG
SG
A
LT
L
GQPNSP
-
-----
-
GV
P
A
D
FAKHTLTC------TYNDLASVRAAFE-
-
QYPQEI
A
C
II
V
EPV
-
A
G
N
MN
CVPPL
PE
F
L
PG
LR
A
LCDE
F
G
A
LLI
I
DEV
MT
G
F-
R
VA
L
AG
A
QDYYGVV
PDL
T
C
L
G
K
I
I
G
GG
-
MP
V
G
A
FG
G
R
R
D
VM
D
A
LA
P
T
G
--
PVYQ
A
G
T
LS
GNP
I
A
M
AA
G
F
A
C
L
NEVAQPGVH
E
TLDELTT
RL
A
E
G
L
LE
A
A
E
fig|439855.10.peg.339
Escherichia coli SMS-3-5 (36-340/426)
IEK
A
D
G
AY
L
Y
D
V
D
G
KA
Y
I
D
YVG
SW
GPMVL
GH
N
HP
A
I
R
N
AV
I
E
A
A
ERGLS
F
GA----PT
E
ME
V
K
M
A
Q
L
V
TELV
P
TM--DM
V
RMVN
SG
T
EA
T
M
S
A
I
R
LAR
GFTG-----
-
R
DKI
I
K
F
E
G
C
YHG
H
A
DCLLVKAG
SG
A
LT
L
GQPNSP
-
-----
-
GV
P
A
D
FAKHTLTC------TYNDLASVRAAFE-
-
QYPQEI
A
C
II
V
EPV
-
A
G
N
MN
CVPPL
PE
F
L
PG
LR
A
LCDE
F
G
A
LLI
I
DEV
MT
G
F-
R
VA
L
AG
A
QDYYGVV
PDL
T
C
L
G
K
I
I
G
GG
-
MP
V
G
A
FG
G
R
R
D
VM
D
A
LA
P
T
G
--
PVYQ
A
G
T
LS
GNP
I
A
M
AA
G
F
A
C
L
NEVAQPGVH
E
TLDELTT
RL
A
E
G
L
LE
A
A
E
fig|656443.3.peg.299
Escherichia coli TA271 (36-340/426)
IEK
A
D
G
AY
L
Y
D
V
D
G
KA
Y
I
D
YVG
SW
GPMVL
GH
N
HP
A
I
R
N
AV
I
E
A
A
ERGLS
F
GA----PT
E
ME
V
K
M
A
Q
L
V
TELV
P
TM--DM
V
RMVN
SG
T
EA
T
M
S
A
I
R
LAR
GFTG-----
-
R
DKI
I
K
F
E
G
C
YHG
H
A
DCLLVKAG
SG
A
LT
L
GQPNSP
-
-----
-
GV
P
A
D
FAKHTLTC------TYNDLASVRAAFE-
-
QYPQEI
A
C
II
V
EPV
-
A
G
N
MN
CVPPL
PE
F
L
PG
LR
A
LCDE
F
G
A
LLI
I
DEV
MT
G
F-
R
VA
L
AG
A
QDYYGVV
PDL
T
C
L
G
K
I
I
G
GG
-
MP
V
G
A
FG
G
R
R
D
VM
D
A
LA
P
T
G
--
PVYQ
A
G
T
LS
GNP
I
A
M
AA
G
F
A
C
L
NEVAQPGVH
E
TLDELTT
RL
A
E
G
L
LE
A
A
E
fig|679207.4.peg.1202
Escherichia coli MS 107-1 (36-338/426)
IEK
A
D
G
AY
L
Y
D
V
D
G
KA
Y
I
D
YVG
SW
GPMVL
GH
N
HP
A
I
R
N
AV
I
E
A
A
ERGLS
F
GA----PT
E
ME
V
K
M
A
Q
L
V
TELV
P
TM--DM
V
RMVN
SG
T
EA
T
M
S
A
I
R
LAR
GFTG-----
-
R
DKI
I
K
F
E
G
C
YHG
H
A
DCLLVKAG
SG
A
LT
L
GQPNSP
-
-----
-
GV
P
A
D
FAKHTLTC------TYNDLASVRAAFE-
-
QYPQEI
A
C
II
V
EPV
-
A
G
N
MN
CVPPL
PE
F
L
PG
LR
A
LCDE
F
G
A
LLI
I
DEV
MT
G
F-
R
VA
L
AG
A
QDYYGVV
PDL
T
C
L
G
K
I
I
G
GG
-
MP
V
G
A
FG
G
R
R
D
VM
D
A
LA
P
T
G
--
PVYQ
A
G
T
LS
GNP
I
A
M
AA
G
F
A
C
L
NEVAQPGVH
E
TLDELTT
RL
A
E
G
L
LE
A
fig|670897.3.peg.1982
Escherichia coli 2362-75 (36-340/426)
IEK
A
D
G
AY
L
Y
D
V
D
G
KA
Y
I
D
YVG
SW
GPMVL
GH
N
HP
A
I
R
N
AV
I
E
A
A
ERGLS
F
GA----PT
E
ME
V
K
M
A
Q
L
V
TELV
P
TM--DM
V
RMVN
SG
T
EA
T
M
S
A
I
R
LAR
GFTG-----
-
R
DKI
I
K
F
E
G
C
YHG
H
A
DCLLVKAG
SG
A
LT
L
GQPNSP
-
-----
-
GV
P
A
D
FAKHTLTC------TYNDLASVRAAFE-
-
QYPQEI
A
C
II
V
EPV
-
A
G
N
MN
CVPPL
PE
F
L
PG
LR
A
LCDE
F
G
A
LLI
I
DEV
MT
G
F-
R
VA
L
AG
A
QDYYGVE
PDL
T
C
L
G
K
I
I
G
GG
-
MP
V
G
A
FG
G
R
R
D
VM
D
A
LA
P
T
G
--
PVYQ
A
G
T
LS
GNP
I
A
M
AA
G
F
A
C
L
NEVAQPGVH
E
TLDELTT
RL
A
E
G
L
RE
A
A
E
fig|362663.8.peg.167
Escherichia coli 536 (36-340/426)
IEK
A
D
G
AY
L
Y
D
V
D
G
KA
Y
I
D
YVG
SW
GPMVL
GH
N
HP
A
I
R
N
AV
I
E
A
A
ERGLS
F
GA----PT
E
ME
V
K
M
A
Q
L
V
TELV
P
TM--DM
V
RMVN
SG
T
EA
T
M
S
A
I
R
LAR
GFTG-----
-
R
DKI
I
K
F
E
G
C
YHG
H
A
DCLLVKAG
SG
A
LT
L
GQPNSP
-
-----
-
GV
P
A
D
FAKHTLTC------TYNDLASVRAAFE-
-
QYPQEI
A
C
II
V
EPV
-
A
G
N
MN
CVPPL
PE
F
L
PG
LR
A
LCDE
F
G
A
LLI
I
DEV
MT
G
F-
R
VA
L
AG
A
QDYYGVE
PDL
T
C
L
G
K
I
I
G
GG
-
MP
V
G
A
FG
G
R
R
D
VM
D
A
LA
P
T
G
--
PVYQ
A
G
T
LS
GNP
I
A
M
AA
G
F
A
C
L
NEVAQPGVH
E
TLDELTT
RL
A
E
G
L
RE
A
A
E
fig|362663.9.peg.167
Escherichia coli 536 (36-340/426)
IEK
A
D
G
AY
L
Y
D
V
D
G
KA
Y
I
D
YVG
SW
GPMVL
GH
N
HP
A
I
R
N
AV
I
E
A
A
ERGLS
F
GA----PT
E
ME
V
K
M
A
Q
L
V
TELV
P
TM--DM
V
RMVN
SG
T
EA
T
M
S
A
I
R
LAR
GFTG-----
-
R
DKI
I
K
F
E
G
C
YHG
H
A
DCLLVKAG
SG
A
LT
L
GQPNSP
-
-----
-
GV
P
A
D
FAKHTLTC------TYNDLASVRAAFE-
-
QYPQEI
A
C
II
V
EPV
-
A
G
N
MN
CVPPL
PE
F
L
PG
LR
A
LCDE
F
G
A
LLI
I
DEV
MT
G
F-
R
VA
L
AG
A
QDYYGVE
PDL
T
C
L
G
K
I
I
G
GG
-
MP
V
G
A
FG
G
R
R
D
VM
D
A
LA
P
T
G
--
PVYQ
A
G
T
LS
GNP
I
A
M
AA
G
F
A
C
L
NEVAQPGVH
E
TLDELTT
RL
A
E
G
L
RE
A
A
E
fig|525281.3.peg.1107
Escherichia coli 83972 (36-340/426)
IEK
A
D
G
AY
L
Y
D
V
D
G
KA
Y
I
D
YVG
SW
GPMVL
GH
N
HP
A
I
R
N
AV
I
E
A
A
ERGLS
F
GA----PT
E
ME
V
K
M
A
Q
L
V
TELV
P
TM--DM
V
RMVN
SG
T
EA
T
M
S
A
I
R
LAR
GFTG-----
-
R
DKI
I
K
F
E
G
C
YHG
H
A
DCLLVKAG
SG
A
LT
L
GQPNSP
-
-----
-
GV
P
A
D
FAKHTLTC------TYNDLASVRAAFE-
-
QYPQEI
A
C
II
V
EPV
-
A
G
N
MN
CVPPL
PE
F
L
PG
LR
A
LCDE
F
G
A
LLI
I
DEV
MT
G
F-
R
VA
L
AG
A
QDYYGVE
PDL
T
C
L
G
K
I
I
G
GG
-
MP
V
G
A
FG
G
R
R
D
VM
D
A
LA
P
T
G
--
PVYQ
A
G
T
LS
GNP
I
A
M
AA
G
F
A
C
L
NEVAQPGVH
E
TLDELTT
RL
A
E
G
L
RE
A
A
E
fig|655817.3.peg.182
Escherichia coli ABU 83972 (36-340/426)
IEK
A
D
G
AY
L
Y
D
V
D
G
KA
Y
I
D
YVG
SW
GPMVL
GH
N
HP
A
I
R
N
AV
I
E
A
A
ERGLS
F
GA----PT
E
ME
V
K
M
A
Q
L
V
TELV
P
TM--DM
V
RMVN
SG
T
EA
T
M
S
A
I
R
LAR
GFTG-----
-
R
DKI
I
K
F
E
G
C
YHG
H
A
DCLLVKAG
SG
A
LT
L
GQPNSP
-
-----
-
GV
P
A
D
FAKHTLTC------TYNDLASVRAAFE-
-
QYPQEI
A
C
II
V
EPV
-
A
G
N
MN
CVPPL
PE
F
L
PG
LR
A
LCDE
F
G
A
LLI
I
DEV
MT
G
F-
R
VA
L
AG
A
QDYYGVE
PDL
T
C
L
G
K
I
I
G
GG
-
MP
V
G
A
FG
G
R
R
D
VM
D
A
LA
P
T
G
--
PVYQ
A
G
T
LS
GNP
I
A
M
AA
G
F
A
C
L
NEVAQPGVH
E
TLDELTT
RL
A
E
G
L
RE
A
A
E
fig|405955.13.peg.167
Escherichia coli APEC O1 (36-340/426)
IEK
A
D
G
AY
L
Y
D
V
D
G
KA
Y
I
D
YVG
SW
GPMVL
GH
N
HP
A
I
R
N
AV
I
E
A
A
ERGLS
F
GA----PT
E
ME
V
K
M
A
Q
L
V
TELV
P
TM--DM
V
RMVN
SG
T
EA
T
M
S
A
I
R
LAR
GFTG-----
-
R
DKI
I
K
F
E
G
C
YHG
H
A
DCLLVKAG
SG
A
LT
L
GQPNSP
-
-----
-
GV
P
A
D
FAKHTLTC------TYNDLASVRAAFE-
-
QYPQEI
A
C
II
V
EPV
-
A
G
N
MN
CVPPL
PE
F
L
PG
LR
A
LCDE
F
G
A
LLI
I
DEV
MT
G
F-
R
VA
L
AG
A
QDYYGVE
PDL
T
C
L
G
K
I
I
G
GG
-
MP
V
G
A
FG
G
R
R
D
VM
D
A
LA
P
T
G
--
PVYQ
A
G
T
LS
GNP
I
A
M
AA
G
F
A
C
L
NEVAQPGVH
E
TLDELTT
RL
A
E
G
L
RE
A
A
E
fig|405955.9.peg.136
Escherichia coli APEC O1 (36-340/426)
IEK
A
D
G
AY
L
Y
D
V
D
G
KA
Y
I
D
YVG
SW
GPMVL
GH
N
HP
A
I
R
N
AV
I
E
A
A
ERGLS
F
GA----PT
E
ME
V
K
M
A
Q
L
V
TELV
P
TM--DM
V
RMVN
SG
T
EA
T
M
S
A
I
R
LAR
GFTG-----
-
R
DKI
I
K
F
E
G
C
YHG
H
A
DCLLVKAG
SG
A
LT
L
GQPNSP
-
-----
-
GV
P
A
D
FAKHTLTC------TYNDLASVRAAFE-
-
QYPQEI
A
C
II
V
EPV
-
A
G
N
MN
CVPPL
PE
F
L
PG
LR
A
LCDE
F
G
A
LLI
I
DEV
MT
G
F-
R
VA
L
AG
A
QDYYGVE
PDL
T
C
L
G
K
I
I
G
GG
-
MP
V
G
A
FG
G
R
R
D
VM
D
A
LA
P
T
G
--
PVYQ
A
G
T
LS
GNP
I
A
M
AA
G
F
A
C
L
NEVAQPGVH
E
TLDELTT
RL
A
E
G
L
RE
A
A
E
fig|199310.1.peg.183
Escherichia coli CFT073 (36-340/426)
IEK
A
D
G
AY
L
Y
D
V
D
G
KA
Y
I
D
YVG
SW
GPMVL
GH
N
HP
A
I
R
N
AV
I
E
A
A
ERGLS
F
GA----PT
E
ME
V
K
M
A
Q
L
V
TELV
P
TM--DM
V
RMVN
SG
T
EA
T
M
S
A
I
R
LAR
GFTG-----
-
R
DKI
I
K
F
E
G
C
YHG
H
A
DCLLVKAG
SG
A
LT
L
GQPNSP
-
-----
-
GV
P
A
D
FAKHTLTC------TYNDLASVRAAFE-
-
QYPQEI
A
C
II
V
EPV
-
A
G
N
MN
CVPPL
PE
F
L
PG
LR
A
LCDE
F
G
A
LLI
I
DEV
MT
G
F-
R
VA
L
AG
A
QDYYGVE
PDL
T
C
L
G
K
I
I
G
GG
-
MP
V
G
A
FG
G
R
R
D
VM
D
A
LA
P
T
G
--
PVYQ
A
G
T
LS
GNP
I
A
M
AA
G
F
A
C
L
NEVAQPGVH
E
TLDELTT
RL
A
E
G
L
RE
A
A
E
fig|199310.4.peg.178
Escherichia coli CFT073 (36-340/426)
IEK
A
D
G
AY
L
Y
D
V
D
G
KA
Y
I
D
YVG
SW
GPMVL
GH
N
HP
A
I
R
N
AV
I
E
A
A
ERGLS
F
GA----PT
E
ME
V
K
M
A
Q
L
V
TELV
P
TM--DM
V
RMVN
SG
T
EA
T
M
S
A
I
R
LAR
GFTG-----
-
R
DKI
I
K
F
E
G
C
YHG
H
A
DCLLVKAG
SG
A
LT
L
GQPNSP
-
-----
-
GV
P
A
D
FAKHTLTC------TYNDLASVRAAFE-
-
QYPQEI
A
C
II
V
EPV
-
A
G
N
MN
CVPPL
PE
F
L
PG
LR
A
LCDE
F
G
A
LLI
I
DEV
MT
G
F-
R
VA
L
AG
A
QDYYGVE
PDL
T
C
L
G
K
I
I
G
GG
-
MP
V
G
A
FG
G
R
R
D
VM
D
A
LA
P
T
G
--
PVYQ
A
G
T
LS
GNP
I
A
M
AA
G
F
A
C
L
NEVAQPGVH
E
TLDELTT
RL
A
E
G
L
RE
A
A
E
fig|216593.1.peg.3407
Escherichia coli E2348/69 (36-340/426)
IEK
A
D
G
AY
L
Y
D
V
D
G
KA
Y
I
D
YVG
SW
GPMVL
GH
N
HP
A
I
R
N
AV
I
E
A
A
ERGLS
F
GA----PT
E
ME
V
K
M
A
Q
L
V
TELV
P
TM--DM
V
RMVN
SG
T
EA
T
M
S
A
I
R
LAR
GFTG-----
-
R
DKI
I
K
F
E
G
C
YHG
H
A
DCLLVKAG
SG
A
LT
L
GQPNSP
-
-----
-
GV
P
A
D
FAKHTLTC------TYNDLASVRAAFE-
-
QYPQEI
A
C
II
V
EPV
-
A
G
N
MN
CVPPL
PE
F
L
PG
LR
A
LCDE
F
G
A
LLI
I
DEV
MT
G
F-
R
VA
L
AG
A
QDYYGVE
PDL
T
C
L
G
K
I
I
G
GG
-
MP
V
G
A
FG
G
R
R
D
VM
D
A
LA
P
T
G
--
PVYQ
A
G
T
LS
GNP
I
A
M
AA
G
F
A
C
L
NEVAQPGVH
E
TLDELTT
RL
A
E
G
L
RE
A
A
E
fig|585397.7.peg.165
Escherichia coli ED1a (36-340/426)
IEK
A
D
G
AY
L
Y
D
V
D
G
KA
Y
I
D
YVG
SW
GPMVL
GH
N
HP
A
I
R
N
AV
I
E
A
A
ERGLS
F
GA----PT
E
ME
V
K
M
A
Q
L
V
TELV
P
TM--DM
V
RMVN
SG
T
EA
T
M
S
A
I
R
LAR
GFTG-----
-
R
DKI
I
K
F
E
G
C
YHG
H
A
DCLLVKAG
SG
A
LT
L
GQPNSP
-
-----
-
GV
P
A
D
FAKHTLTC------TYNDLASVRAAFE-
-
QYPQEI
A
C
II
V
EPV
-
A
G
N
MN
CVPPL
PE
F
L
PG
LR
A
LCDE
F
G
A
LLI
I
DEV
MT
G
F-
R
VA
L
AG
A
QDYYGVE
PDL
T
C
L
G
K
I
I
G
GG
-
MP
V
G
A
FG
G
R
R
D
VM
D
A
LA
P
T
G
--
PVYQ
A
G
T
LS
GNP
I
A
M
AA
G
F
A
C
L
NEVAQPGVH
E
TLDELTT
RL
A
E
G
L
RE
A
A
E
fig|585397.9.peg.165
Escherichia coli ED1a (36-340/426)
IEK
A
D
G
AY
L
Y
D
V
D
G
KA
Y
I
D
YVG
SW
GPMVL
GH
N
HP
A
I
R
N
AV
I
E
A
A
ERGLS
F
GA----PT
E
ME
V
K
M
A
Q
L
V
TELV
P
TM--DM
V
RMVN
SG
T
EA
T
M
S
A
I
R
LAR
GFTG-----
-
R
DKI
I
K
F
E
G
C
YHG
H
A
DCLLVKAG
SG
A
LT
L
GQPNSP
-
-----
-
GV
P
A
D
FAKHTLTC------TYNDLASVRAAFE-
-
QYPQEI
A
C
II
V
EPV
-
A
G
N
MN
CVPPL
PE
F
L
PG
LR
A
LCDE
F
G
A
LLI
I
DEV
MT
G
F-
R
VA
L
AG
A
QDYYGVE
PDL
T
C
L
G
K
I
I
G
GG
-
MP
V
G
A
FG
G
R
R
D
VM
D
A
LA
P
T
G
--
PVYQ
A
G
T
LS
GNP
I
A
M
AA
G
F
A
C
L
NEVAQPGVH
E
TLDELTT
RL
A
E
G
L
RE
A
A
E
fig|340197.3.peg.2899
Escherichia coli F11 (36-340/426)
IEK
A
D
G
AY
L
Y
D
V
D
G
KA
Y
I
D
YVG
SW
GPMVL
GH
N
HP
A
I
R
N
AV
I
E
A
A
ERGLS
F
GA----PT
E
ME
V
K
M
A
Q
L
V
TELV
P
TM--DM
V
RMVN
SG
T
EA
T
M
S
A
I
R
LAR
GFTG-----
-
R
DKI
I
K
F
E
G
C
YHG
H
A
DCLLVKAG
SG
A
LT
L
GQPNSP
-
-----
-
GV
P
A
D
FAKHTLTC------TYNDLASVRAAFE-
-
QYPQEI
A
C
II
V
EPV
-
A
G
N
MN
CVPPL
PE
F
L
PG
LR
A
LCDE
F
G
A
LLI
I
DEV
MT
G
F-
R
VA
L
AG
A
QDYYGVE
PDL
T
C
L
G
K
I
I
G
GG
-
MP
V
G
A
FG
G
R
R
D
VM
D
A
LA
P
T
G
--
PVYQ
A
G
T
LS
GNP
I
A
M
AA
G
F
A
C
L
NEVAQPGVH
E
TLDELTT
RL
A
E
G
L
RE
A
A
E
fig|340197.5.peg.3030
Escherichia coli F11 (36-340/426)
IEK
A
D
G
AY
L
Y
D
V
D
G
KA
Y
I
D
YVG
SW
GPMVL
GH
N
HP
A
I
R
N
AV
I
E
A
A
ERGLS
F
GA----PT
E
ME
V
K
M
A
Q
L
V
TELV
P
TM--DM
V
RMVN
SG
T
EA
T
M
S
A
I
R
LAR
GFTG-----
-
R
DKI
I
K
F
E
G
C
YHG
H
A
DCLLVKAG
SG
A
LT
L
GQPNSP
-
-----
-
GV
P
A
D
FAKHTLTC------TYNDLASVRAAFE-
-
QYPQEI
A
C
II
V
EPV
-
A
G
N
MN
CVPPL
PE
F
L
PG
LR
A
LCDE
F
G
A
LLI
I
DEV
MT
G
F-
R
VA
L
AG
A
QDYYGVE
PDL
T
C
L
G
K
I
I
G
GG
-
MP
V
G
A
FG
G
R
R
D
VM
D
A
LA
P
T
G
--
PVYQ
A
G
T
LS
GNP
I
A
M
AA
G
F
A
C
L
NEVAQPGVH
E
TLDELTT
RL
A
E
G
L
RE
A
A
E
fig|656393.3.peg.773
Escherichia coli H299 (36-340/426)
IEK
A
D
G
AY
L
Y
D
V
D
G
KA
Y
I
D
YVG
SW
GPMVL
GH
N
HP
A
I
R
N
AV
I
E
A
A
ERGLS
F
GA----PT
E
ME
V
K
M
A
Q
L
V
TELV
P
TM--DM
V
RMVN
SG
T
EA
T
M
S
A
I
R
LAR
GFTG-----
-
R
DKI
I
K
F
E
G
C
YHG
H
A
DCLLVKAG
SG
A
LT
L
GQPNSP
-
-----
-
GV
P
A
D
FAKHTLTC------TYNDLASVRAAFE-
-
QYPQEI
A
C
II
V
EPV
-
A
G
N
MN
CVPPL
PE
F
L
PG
LR
A
LCDE
F
G
A
LLI
I
DEV
MT
G
F-
R
VA
L
AG
A
QDYYGVE
PDL
T
C
L
G
K
I
I
G
GG
-
MP
V
G
A
FG
G
R
R
D
VM
D
A
LA
P
T
G
--
PVYQ
A
G
T
LS
GNP
I
A
M
AA
G
F
A
C
L
NEVAQPGVH
E
TLDELTT
RL
A
E
G
L
RE
A
A
E
fig|714962.3.peg.164
Escherichia coli IHE3034 (36-340/426)
IEK
A
D
G
AY
L
Y
D
V
D
G
KA
Y
I
D
YVG
SW
GPMVL
GH
N
HP
A
I
R
N
AV
I
E
A
A
ERGLS
F
GA----PT
E
ME
V
K
M
A
Q
L
V
TELV
P
TM--DM
V
RMVN
SG
T
EA
T
M
S
A
I
R
LAR
GFTG-----
-
R
DKI
I
K
F
E
G
C
YHG
H
A
DCLLVKAG
SG
A
LT
L
GQPNSP
-
-----
-
GV
P
A
D
FAKHTLTC------TYNDLASVRAAFE-
-
QYPQEI
A
C
II
V
EPV
-
A
G
N
MN
CVPPL
PE
F
L
PG
LR
A
LCDE
F
G
A
LLI
I
DEV
MT
G
F-
R
VA
L
AG
A
QDYYGVE
PDL
T
C
L
G
K
I
I
G
GG
-
MP
V
G
A
FG
G
R
R
D
VM
D
A
LA
P
T
G
--
PVYQ
A
G
T
LS
GNP
I
A
M
AA
G
F
A
C
L
NEVAQPGVH
E
TLDELTT
RL
A
E
G
L
RE
A
A
E
fig|656417.3.peg.258
Escherichia coli M605 (36-340/426)
IEK
A
D
G
AY
L
Y
D
V
D
G
KA
Y
I
D
YVG
SW
GPMVL
GH
N
HP
A
I
R
N
AV
I
E
A
A
ERGLS
F
GA----PT
E
ME
V
K
M
A
Q
L
V
TELV
P
TM--DM
V
RMVN
SG
T
EA
T
M
S
A
I
R
LAR
GFTG-----
-
R
DKI
I
K
F
E
G
C
YHG
H
A
DCLLVKAG
SG
A
LT
L
GQPNSP
-
-----
-
GV
P
A
D
FAKHTLTC------TYNDLASVRAAFE-
-
QYPQEI
A
C
II
V
EPV
-
A
G
N
MN
CVPPL
PE
F
L
PG
LR
A
LCDE
F
G
A
LLI
I
DEV
MT
G
F-
R
VA
L
AG
A
QDYYGVE
PDL
T
C
L
G
K
I
I
G
GG
-
MP
V
G
A
FG
G
R
R
D
VM
D
A
LA
P
T
G
--
PVYQ
A
G
T
LS
GNP
I
A
M
AA
G
F
A
C
L
NEVAQPGVH
E
TLDELTT
RL
A
E
G
L
RE
A
A
E
fig|749546.3.peg.3722
Escherichia coli MS 185-1 (36-340/426)
IEK
A
D
G
AY
L
Y
D
V
D
G
KA
Y
I
D
YVG
SW
GPMVL
GH
N
HP
A
I
R
N
AV
I
E
A
A
ERGLS
F
GA----PT
E
ME
V
K
M
A
Q
L
V
TELV
P
TM--DM
V
RMVN
SG
T
EA
T
M
S
A
I
R
LAR
GFTG-----
-
R
DKI
I
K
F
E
G
C
YHG
H
A
DCLLVKAG
SG
A
LT
L
GQPNSP
-
-----
-
GV
P
A
D
FAKHTLTC------TYNDLASVRAAFE-
-
QYPQEI
A
C
II
V
EPV
-
A
G
N
MN
CVPPL
PE
F
L
PG
LR
A
LCDE
F
G
A
LLI
I
DEV
MT
G
F-
R
VA
L
AG
A
QDYYGVE
PDL
T
C
L
G
K
I
I
G
GG
-
MP
V
G
A
FG
G
R
R
D
VM
D
A
LA
P
T
G
--
PVYQ
A
G
T
LS
GNP
I
A
M
AA
G
F
A
C
L
NEVAQPGVH
E
TLDELTT
RL
A
E
G
L
RE
A
A
E
fig|749550.3.peg.2483
Escherichia coli MS 200-1 (36-340/426)
IEK
A
D
G
AY
L
Y
D
V
D
G
KA
Y
I
D
YVG
SW
GPMVL
GH
N
HP
A
I
R
N
AV
I
E
A
A
ERGLS
F
GA----PT
E
ME
V
K
M
A
Q
L
V
TELV
P
TM--DM
V
RMVN
SG
T
EA
T
M
S
A
I
R
LAR
GFTG-----
-
R
DKI
I
K
F
E
G
C
YHG
H
A
DCLLVKAG
SG
A
LT
L
GQPNSP
-
-----
-
GV
P
A
D
FAKHTLTC------TYNDLASVRAAFE-
-
QYPQEI
A
C
II
V
EPV
-
A
G
N
MN
CVPPL
PE
F
L
PG
LR
A
LCDE
F
G
A
LLI
I
DEV
MT
G
F-
R
VA
L
AG
A
QDYYGVE
PDL
T
C
L
G
K
I
I
G
GG
-
MP
V
G
A
FG
G
R
R
D
VM
D
A
LA
P
T
G
--
PVYQ
A
G
T
LS
GNP
I
A
M
AA
G
F
A
C
L
NEVAQPGVH
E
TLDELTT
RL
A
E
G
L
RE
A
A
E
fig|749528.3.peg.4658
Escherichia coli MS 45-1 (36-340/426)
IEK
A
D
G
AY
L
Y
D
V
D
G
KA
Y
I
D
YVG
SW
GPMVL
GH
N
HP
A
I
R
N
AV
I
E
A
A
ERGLS
F
GA----PT
E
ME
V
K
M
A
Q
L
V
TELV
P
TM--DM
V
RMVN
SG
T
EA
T
M
S
A
I
R
LAR
GFTG-----
-
R
DKI
I
K
F
E
G
C
YHG
H
A
DCLLVKAG
SG
A
LT
L
GQPNSP
-
-----
-
GV
P
A
D
FAKHTLTC------TYNDLASVRAAFE-
-
QYPQEI
A
C
II
V
EPV
-
A
G
N
MN
CVPPL
PE
F
L
PG
LR
A
LCDE
F
G
A
LLI
I
DEV
MT
G
F-
R
VA
L
AG
A
QDYYGVE
PDL
T
C
L
G
K
I
I
G
GG
-
MP
V
G
A
FG
G
R
R
D
VM
D
A
LA
P
T
G
--
PVYQ
A
G
T
LS
GNP
I
A
M
AA
G
F
A
C
L
NEVAQPGVH
E
TLDELTT
RL
A
E
G
L
RE
A
A
E
fig|753642.3.peg.3466
Escherichia coli NC101 (36-340/426)
IEK
A
D
G
AY
L
Y
D
V
D
G
KA
Y
I
D
YVG
SW
GPMVL
GH
N
HP
A
I
R
N
AV
I
E
A
A
ERGLS
F
GA----PT
E
ME
V
K
M
A
Q
L
V
TELV
P
TM--DM
V
RMVN
SG
T
EA
T
M
S
A
I
R
LAR
GFTG-----
-
R
DKI
I
K
F
E
G
C
YHG
H
A
DCLLVKAG
SG
A
LT
L
GQPNSP
-
-----
-
GV
P
A
D
FAKHTLTC------TYNDLASVRAAFE-
-
QYPQEI
A
C
II
V
EPV
-
A
G
N
MN
CVPPL
PE
F
L
PG
LR
A
LCDE
F
G
A
LLI
I
DEV
MT
G
F-
R
VA
L
AG
A
QDYYGVE
PDL
T
C
L
G
K
I
I
G
GG
-
MP
V
G
A
FG
G
R
R
D
VM
D
A
LA
P
T
G
--
PVYQ
A
G
T
LS
GNP
I
A
M
AA
G
F
A
C
L
NEVAQPGVH
E
TLDELTT
RL
A
E
G
L
RE
A
A
E
fig|574521.7.peg.169
Escherichia coli O127:H6 str. E2348/69 (36-340/426)
IEK
A
D
G
AY
L
Y
D
V
D
G
KA
Y
I
D
YVG
SW
GPMVL
GH
N
HP
A
I
R
N
AV
I
E
A
A
ERGLS
F
GA----PT
E
ME
V
K
M
A
Q
L
V
TELV
P
TM--DM
V
RMVN
SG
T
EA
T
M
S
A
I
R
LAR
GFTG-----
-
R
DKI
I
K
F
E
G
C
YHG
H
A
DCLLVKAG
SG
A
LT
L
GQPNSP
-
-----
-
GV
P
A
D
FAKHTLTC------TYNDLASVRAAFE-
-
QYPQEI
A
C
II
V
EPV
-
A
G
N
MN
CVPPL
PE
F
L
PG
LR
A
LCDE
F
G
A
LLI
I
DEV
MT
G
F-
R
VA
L
AG
A
QDYYGVE
PDL
T
C
L
G
K
I
I
G
GG
-
MP
V
G
A
FG
G
R
R
D
VM
D
A
LA
P
T
G
--
PVYQ
A
G
T
LS
GNP
I
A
M
AA
G
F
A
C
L
NEVAQPGVH
E
TLDELTT
RL
A
E
G
L
RE
A
A
E
fig|685038.3.peg.161
Escherichia coli O83:H1 str. NRG 857C (36-340/426)
IEK
A
D
G
AY
L
Y
D
V
D
G
KA
Y
I
D
YVG
SW
GPMVL
GH
N
HP
A
I
R
N
AV
I
E
A
A
ERGLS
F
GA----PT
E
ME
V
K
M
A
Q
L
V
TELV
P
TM--DM
V
RMVN
SG
T
EA
T
M
S
A
I
R
LAR
GFTG-----
-
R
DKI
I
K
F
E
G
C
YHG
H
A
DCLLVKAG
SG
A
LT
L
GQPNSP
-
-----
-
GV
P
A
D
FAKHTLTC------TYNDLASVRAAFE-
-
QYPQEI
A
C
II
V
EPV
-
A
G
N
MN
CVPPL
PE
F
L
PG
LR
A
LCDE
F
G
A
LLI
I
DEV
MT
G
F-
R
VA
L
AG
A
QDYYGVE
PDL
T
C
L
G
K
I
I
G
GG
-
MP
V
G
A
FG
G
R
R
D
VM
D
A
LA
P
T
G
--
PVYQ
A
G
T
LS
GNP
I
A
M
AA
G
F
A
C
L
NEVAQPGVH
E
TLDELTT
RL
A
E
G
L
RE
A
A
E
fig|585035.6.peg.168
Escherichia coli S88 (36-340/426)
IEK
A
D
G
AY
L
Y
D
V
D
G
KA
Y
I
D
YVG
SW
GPMVL
GH
N
HP
A
I
R
N
AV
I
E
A
A
ERGLS
F
GA----PT
E
ME
V
K
M
A
Q
L
V
TELV
P
TM--DM
V
RMVN
SG
T
EA
T
M
S
A
I
R
LAR
GFTG-----
-
R
DKI
I
K
F
E
G
C
YHG
H
A
DCLLVKAG
SG
A
LT
L
GQPNSP
-
-----
-
GV
P
A
D
FAKHTLTC------TYNDLASVRAAFE-
-
QYPQEI
A
C
II
V
EPV
-
A
G
N
MN
CVPPL
PE
F
L
PG
LR
A
LCDE
F
G
A
LLI
I
DEV
MT
G
F-
R
VA
L
AG
A
QDYYGVE
PDL
T
C
L
G
K
I
I
G
GG
-
MP
V
G
A
FG
G
R
R
D
VM
D
A
LA
P
T
G
--
PVYQ
A
G
T
LS
GNP
I
A
M
AA
G
F
A
C
L
NEVAQPGVH
E
TLDELTT
RL
A
E
G
L
RE
A
A
E
fig|431946.3.peg.175
Escherichia coli SE15 (36-340/426)
IEK
A
D
G
AY
L
Y
D
V
D
G
KA
Y
I
D
YVG
SW
GPMVL
GH
N
HP
A
I
R
N
AV
I
E
A
A
ERGLS
F
GA----PT
E
ME
V
K
M
A
Q
L
V
TELV
P
TM--DM
V
RMVN
SG
T
EA
T
M
S
A
I
R
LAR
GFTG-----
-
R
DKI
I
K
F
E
G
C
YHG
H
A
DCLLVKAG
SG
A
LT
L
GQPNSP
-
-----
-
GV
P
A
D
FAKHTLTC------TYNDLASVRAAFE-
-
QYPQEI
A
C
II
V
EPV
-
A
G
N
MN
CVPPL
PE
F
L
PG
LR
A
LCDE
F
G
A
LLI
I
DEV
MT
G
F-
R
VA
L
AG
A
QDYYGVE
PDL
T
C
L
G
K
I
I
G
GG
-
MP
V
G
A
FG
G
R
R
D
VM
D
A
LA
P
T
G
--
PVYQ
A
G
T
LS
GNP
I
A
M
AA
G
F
A
C
L
NEVAQPGVH
E
TLDELTT
RL
A
E
G
L
RE
A
A
E
fig|656444.3.peg.495
Escherichia coli TA280 (36-340/426)
IEK
A
D
G
AY
L
Y
D
V
D
G
KA
Y
I
D
YVG
SW
GPMVL
GH
N
HP
A
I
R
N
AV
I
E
A
A
ERGLS
F
GA----PT
E
ME
V
K
M
A
Q
L
V
TELV
P
TM--DM
V
RMVN
SG
T
EA
T
M
S
A
I
R
LAR
GFTG-----
-
R
DKI
I
K
F
E
G
C
YHG
H
A
DCLLVKAG
SG
A
LT
L
GQPNSP
-
-----
-
GV
P
A
D
FAKHTLTC------TYNDLASVRAAFE-
-
QYPQEI
A
C
II
V
EPV
-
A
G
N
MN
CVPPL
PE
F
L
PG
LR
A
LCDE
F
G
A
LLI
I
DEV
MT
G
F-
R
VA
L
AG
A
QDYYGVE
PDL
T
C
L
G
K
I
I
G
GG
-
MP
V
G
A
FG
G
R
R
D
VM
D
A
LA
P
T
G
--
PVYQ
A
G
T
LS
GNP
I
A
M
AA
G
F
A
C
L
NEVAQPGVH
E
TLDELTT
RL
A
E
G
L
RE
A
A
E
fig|869729.3.peg.5072
Escherichia coli UM146 (36-340/426)
IEK
A
D
G
AY
L
Y
D
V
D
G
KA
Y
I
D
YVG
SW
GPMVL
GH
N
HP
A
I
R
N
AV
I
E
A
A
ERGLS
F
GA----PT
E
ME
V
K
M
A
Q
L
V
TELV
P
TM--DM
V
RMVN
SG
T
EA
T
M
S
A
I
R
LAR
GFTG-----
-
R
DKI
I
K
F
E
G
C
YHG
H
A
DCLLVKAG
SG
A
LT
L
GQPNSP
-
-----
-
GV
P
A
D
FAKHTLTC------TYNDLASVRAAFE-
-
QYPQEI
A
C
II
V
EPV
-
A
G
N
MN
CVPPL
PE
F
L
PG
LR
A
LCDE
F
G
A
LLI
I
DEV
MT
G
F-
R
VA
L
AG
A
QDYYGVE
PDL
T
C
L
G
K
I
I
G
GG
-
MP
V
G
A
FG
G
R
R
D
VM
D
A
LA
P
T
G
--
PVYQ
A
G
T
LS
GNP
I
A
M
AA
G
F
A
C
L
NEVAQPGVH
E
TLDELTT
RL
A
E
G
L
RE
A
A
E
fig|364106.7.peg.299
Escherichia coli UTI89 (36-340/426)
IEK
A
D
G
AY
L
Y
D
V
D
G
KA
Y
I
D
YVG
SW
GPMVL
GH
N
HP
A
I
R
N
AV
I
E
A
A
ERGLS
F
GA----PT
E
ME
V
K
M
A
Q
L
V
TELV
P
TM--DM
V
RMVN
SG
T
EA
T
M
S
A
I
R
LAR
GFTG-----
-
R
DKI
I
K
F
E
G
C
YHG
H
A
DCLLVKAG
SG
A
LT
L
GQPNSP
-
-----
-
GV
P
A
D
FAKHTLTC------TYNDLASVRAAFE-
-
QYPQEI
A
C
II
V
EPV
-
A
G
N
MN
CVPPL
PE
F
L
PG
LR
A
LCDE
F
G
A
LLI
I
DEV
MT
G
F-
R
VA
L
AG
A
QDYYGVE
PDL
T
C
L
G
K
I
I
G
GG
-
MP
V
G
A
FG
G
R
R
D
VM
D
A
LA
P
T
G
--
PVYQ
A
G
T
LS
GNP
I
A
M
AA
G
F
A
C
L
NEVAQPGVH
E
TLDELTT
RL
A
E
G
L
RE
A
A
E
fig|364106.8.peg.297
Escherichia coli UTI89 (36-340/426)
IEK
A
D
G
AY
L
Y
D
V
D
G
KA
Y
I
D
YVG
SW
GPMVL
GH
N
HP
A
I
R
N
AV
I
E
A
A
ERGLS
F
GA----PT
E
ME
V
K
M
A
Q
L
V
TELV
P
TM--DM
V
RMVN
SG
T
EA
T
M
S
A
I
R
LAR
GFTG-----
-
R
DKI
I
K
F
E
G
C
YHG
H
A
DCLLVKAG
SG
A
LT
L
GQPNSP
-
-----
-
GV
P
A
D
FAKHTLTC------TYNDLASVRAAFE-
-
QYPQEI
A
C
II
V
EPV
-
A
G
N
MN
CVPPL
PE
F
L
PG
LR
A
LCDE
F
G
A
LLI
I
DEV
MT
G
F-
R
VA
L
AG
A
QDYYGVE
PDL
T
C
L
G
K
I
I
G
GG
-
MP
V
G
A
FG
G
R
R
D
VM
D
A
LA
P
T
G
--
PVYQ
A
G
T
LS
GNP
I
A
M
AA
G
F
A
C
L
NEVAQPGVH
E
TLDELTT
RL
A
E
G
L
RE
A
A
E
fig|562.376.peg.1144
Escherichia coli WV_060327 (36-340/426)
IEK
A
D
G
AY
L
Y
D
V
D
G
KA
Y
I
D
YVG
SW
GPMVL
GH
N
HP
A
I
R
N
AV
I
E
A
A
ERGLS
F
GA----PT
E
ME
V
K
M
A
Q
L
V
TELV
P
TM--DM
V
RMVN
SG
T
EA
T
M
S
A
I
R
LAR
GFTG-----
-
R
DKI
I
K
F
E
G
C
YHG
H
A
DCLLVKAG
SG
A
LT
L
GQPNSP
-
-----
-
GV
P
A
D
FAKHTLTC------TYNDLASVRAAFE-
-
QYPQEI
A
C
II
V
EPV
-
A
G
N
MN
CVPPL
PE
F
L
PG
LR
A
LCDE
F
G
A
LLI
I
DEV
MT
G
F-
R
VA
L
AG
A
QDYYGVE
PDL
T
C
L
G
K
I
I
G
GG
-
MP
V
G
A
FG
G
R
R
D
VM
D
A
LA
P
T
G
--
PVYQ
A
G
T
LS
GNP
I
A
M
AA
G
F
A
C
L
NEVAQPGVH
E
TLDELTT
RL
A
E
G
L
RE
A
A
E
fig|216592.1.peg.4250
Escherichia coli 042 (36-340/426)
IEK
A
D
G
AY
L
Y
D
V
D
G
KA
Y
I
D
YVG
SW
GPMVL
GH
N
HP
A
I
R
N
AV
I
E
A
A
ERGLS
F
GA----PT
E
ME
V
K
M
A
Q
L
V
TELV
P
TM--DM
V
RMVN
SG
T
EA
T
M
S
A
I
R
LAR
GFTG-----
-
R
DKI
I
K
F
E
G
C
YHG
H
A
DCLLVKAG
SG
A
LT
L
GQPNSP
-
-----
-
GV
P
A
D
FAKHTLTC------TYNDLASVRAAFE-
-
QYPQEI
A
C
II
V
EPV
-
A
G
N
MN
CVPPL
PE
F
L
PG
LR
A
LCDE
F
G
A
LLI
I
DEV
MT
G
F-
R
VA
L
AG
A
QDYYGVE
PDL
T
C
L
G
K
I
I
G
GG
-
MP
V
G
A
FG
G
R
R
D
VM
D
A
LA
P
T
G
--
PVYQ
A
G
T
LS
GNP
I
A
M
AA
G
F
A
C
L
NEVAQPGVH
E
TLDELTT
RL
A
E
G
L
LE
A
A
E
fig|216592.3.peg.165
Escherichia coli 042 (36-340/426)
IEK
A
D
G
AY
L
Y
D
V
D
G
KA
Y
I
D
YVG
SW
GPMVL
GH
N
HP
A
I
R
N
AV
I
E
A
A
ERGLS
F
GA----PT
E
ME
V
K
M
A
Q
L
V
TELV
P
TM--DM
V
RMVN
SG
T
EA
T
M
S
A
I
R
LAR
GFTG-----
-
R
DKI
I
K
F
E
G
C
YHG
H
A
DCLLVKAG
SG
A
LT
L
GQPNSP
-
-----
-
GV
P
A
D
FAKHTLTC------TYNDLASVRAAFE-
-
QYPQEI
A
C
II
V
EPV
-
A
G
N
MN
CVPPL
PE
F
L
PG
LR
A
LCDE
F
G
A
LLI
I
DEV
MT
G
F-
R
VA
L
AG
A
QDYYGVE
PDL
T
C
L
G
K
I
I
G
GG
-
MP
V
G
A
FG
G
R
R
D
VM
D
A
LA
P
T
G
--
PVYQ
A
G
T
LS
GNP
I
A
M
AA
G
F
A
C
L
NEVAQPGVH
E
TLDELTT
RL
A
E
G
L
LE
A
A
E
fig|340184.3.peg.1397
Escherichia coli B7A (36-340/426)
IEK
A
D
G
AY
L
Y
D
V
D
G
KA
Y
I
D
YVG
SW
GPMVL
GH
N
HP
A
I
R
N
AV
I
E
A
A
ERGLS
F
GA----PT
E
ME
V
K
M
A
Q
L
V
TELV
P
TM--DM
V
RMVN
SG
T
EA
T
M
S
A
I
R
LAR
GFTG-----
-
R
DKI
I
K
F
E
G
C
YHG
H
A
DCLLVKAG
SG
A
LT
L
GQPNSP
-
-----
-
GV
P
A
D
FAKHTLTC------TYNDLASVRAAFE-
-
QYPQEI
A
C
II
V
EPV
-
A
G
N
MN
CVPPL
PE
F
L
PG
LR
A
LCDE
F
G
A
LLI
I
DEV
MT
G
F-
R
VA
L
AG
A
QDYYGVE
PDL
T
C
L
G
K
I
I
G
GG
-
MP
V
G
A
FG
G
R
R
D
VM
D
A
LA
P
T
G
--
PVYQ
A
G
T
LS
GNP
I
A
M
AA
G
F
A
C
L
NEVAQPGVH
E
TLDELTT
RL
A
E
G
L
LE
A
A
E
fig|340184.6.peg.1475
Escherichia coli B7A (36-340/426)
IEK
A
D
G
AY
L
Y
D
V
D
G
KA
Y
I
D
YVG
SW
GPMVL
GH
N
HP
A
I
R
N
AV
I
E
A
A
ERGLS
F
GA----PT
E
ME
V
K
M
A
Q
L
V
TELV
P
TM--DM
V
RMVN
SG
T
EA
T
M
S
A
I
R
LAR
GFTG-----
-
R
DKI
I
K
F
E
G
C
YHG
H
A
DCLLVKAG
SG
A
LT
L
GQPNSP
-
-----
-
GV
P
A
D
FAKHTLTC------TYNDLASVRAAFE-
-
QYPQEI
A
C
II
V
EPV
-
A
G
N
MN
CVPPL
PE
F
L
PG
LR
A
LCDE
F
G
A
LLI
I
DEV
MT
G
F-
R
VA
L
AG
A
QDYYGVE
PDL
T
C
L
G
K
I
I
G
GG
-
MP
V
G
A
FG
G
R
R
D
VM
D
A
LA
P
T
G
--
PVYQ
A
G
T
LS
GNP
I
A
M
AA
G
F
A
C
L
NEVAQPGVH
E
TLDELTT
RL
A
E
G
L
LE
A
A
E
fig|656379.3.peg.397
Escherichia coli FVEC1302 (36-340/426)
IEK
A
D
G
AY
L
Y
D
V
D
G
KA
Y
I
D
YVG
SW
GPMVL
GH
N
HP
A
I
R
N
AV
I
E
A
A
ERGLS
F
GA----PT
E
ME
V
K
M
A
Q
L
V
TELV
P
TM--DM
V
RMVN
SG
T
EA
T
M
S
A
I
R
LAR
GFTG-----
-
R
DKI
I
K
F
E
G
C
YHG
H
A
DCLLVKAG
SG
A
LT
L
GQPNSP
-
-----
-
GV
P
A
D
FAKHTLTC------TYNDLASVRAAFE-
-
QYPQEI
A
C
II
V
EPV
-
A
G
N
MN
CVPPL
PE
F
L
PG
LR
A
LCDE
F
G
A
LLI
I
DEV
MT
G
F-
R
VA
L
AG
A
QDYYGVE
PDL
T
C
L
G
K
I
I
G
GG
-
MP
V
G
A
FG
G
R
R
D
VM
D
A
LA
P
T
G
--
PVYQ
A
G
T
LS
GNP
I
A
M
AA
G
F
A
C
L
NEVAQPGVH
E
TLDELTT
RL
A
E
G
L
LE
A
A
E
fig|656380.3.peg.334
Escherichia coli FVEC1412 (36-340/426)
IEK
A
D
G
AY
L
Y
D
V
D
G
KA
Y
I
D
YVG
SW
GPMVL
GH
N
HP
A
I
R
N
AV
I
E
A
A
ERGLS
F
GA----PT
E
ME
V
K
M
A
Q
L
V
TELV
P
TM--DM
V
RMVN
SG
T
EA
T
M
S
A
I
R
LAR
GFTG-----
-
R
DKI
I
K
F
E
G
C
YHG
H
A
DCLLVKAG
SG
A
LT
L
GQPNSP
-
-----
-
GV
P
A
D
FAKHTLTC------TYNDLASVRAAFE-
-
QYPQEI
A
C
II
V
EPV
-
A
G
N
MN
CVPPL
PE
F
L
PG
LR
A
LCDE
F
G
A
LLI
I
DEV
MT
G
F-
R
VA
L
AG
A
QDYYGVE
PDL
T
C
L
G
K
I
I
G
GG
-
MP
V
G
A
FG
G
R
R
D
VM
D
A
LA
P
T
G
--
PVYQ
A
G
T
LS
GNP
I
A
M
AA
G
F
A
C
L
NEVAQPGVH
E
TLDELTT
RL
A
E
G
L
LE
A
A
E
fig|331112.3.peg.154
Escherichia coli HS (36-340/426)
IEK
A
D
G
AY
L
Y
D
V
D
G
KA
Y
I
D
YVG
SW
GPMVL
GH
N
HP
A
I
R
N
AV
I
E
A
A
ERGLS
F
GA----PT
E
ME
V
K
M
A
Q
L
V
TELV
P
TM--DM
V
RMVN
SG
T
EA
T
M
S
A
I
R
LAR
GFTG-----
-
R
DKI
I
K
F
E
G
C
YHG
H
A
DCLLVKAG
SG
A
LT
L
GQPNSP
-
-----
-
GV
P
A
D
FAKHTLTC------TYNDLASVRAAFE-
-
QYPQEI
A
C
II
V
EPV
-
A
G
N
MN
CVPPL
PE
F
L
PG
LR
A
LCDE
F
G
A
LLI
I
DEV
MT
G
F-
R
VA
L
AG
A
QDYYGVE
PDL
T
C
L
G
K
I
I
G
GG
-
MP
V
G
A
FG
G
R
R
D
VM
D
A
LA
P
T
G
--
PVYQ
A
G
T
LS
GNP
I
A
M
AA
G
F
A
C
L
NEVAQPGVH
E
TLDELTT
RL
A
E
G
L
LE
A
A
E
fig|331112.6.peg.160
Escherichia coli HS (36-340/426)
IEK
A
D
G
AY
L
Y
D
V
D
G
KA
Y
I
D
YVG
SW
GPMVL
GH
N
HP
A
I
R
N
AV
I
E
A
A
ERGLS
F
GA----PT
E
ME
V
K
M
A
Q
L
V
TELV
P
TM--DM
V
RMVN
SG
T
EA
T
M
S
A
I
R
LAR
GFTG-----
-
R
DKI
I
K
F
E
G
C
YHG
H
A
DCLLVKAG
SG
A
LT
L
GQPNSP
-
-----
-
GV
P
A
D
FAKHTLTC------TYNDLASVRAAFE-
-
QYPQEI
A
C
II
V
EPV
-
A
G
N
MN
CVPPL
PE
F
L
PG
LR
A
LCDE
F
G
A
LLI
I
DEV
MT
G
F-
R
VA
L
AG
A
QDYYGVE
PDL
T
C
L
G
K
I
I
G
GG
-
MP
V
G
A
FG
G
R
R
D
VM
D
A
LA
P
T
G
--
PVYQ
A
G
T
LS
GNP
I
A
M
AA
G
F
A
C
L
NEVAQPGVH
E
TLDELTT
RL
A
E
G
L
LE
A
A
E
fig|679204.3.peg.3456
Escherichia coli MS 145-7 (36-340/426)
IEK
A
D
G
AY
L
Y
D
V
D
G
KA
Y
I
D
YVG
SW
GPMVL
GH
N
HP
A
I
R
N
AV
I
E
A
A
ERGLS
F
GA----PT
E
ME
V
K
M
A
Q
L
V
TELV
P
TM--DM
V
RMVN
SG
T
EA
T
M
S
A
I
R
LAR
GFTG-----
-
R
DKI
I
K
F
E
G
C
YHG
H
A
DCLLVKAG
SG
A
LT
L
GQPNSP
-
-----
-
GV
P
A
D
FAKHTLTC------TYNDLASVRAAFE-
-
QYPQEI
A
C
II
V
EPV
-
A
G
N
MN
CVPPL
PE
F
L
PG
LR
A
LCDE
F
G
A
LLI
I
DEV
MT
G
F-
R
VA
L
AG
A
QDYYGVE
PDL
T
C
L
G
K
I
I
G
GG
-
MP
V
G
A
FG
G
R
R
D
VM
D
A
LA
P
T
G
--
PVYQ
A
G
T
LS
GNP
I
A
M
AA
G
F
A
C
L
NEVAQPGVH
E
TLDELTT
RL
A
E
G
L
LE
A
A
E
fig|749549.3.peg.4662
Escherichia coli MS 198-1 (36-340/426)
IEK
A
D
G
AY
L
Y
D
V
D
G
KA
Y
I
D
YVG
SW
GPMVL
GH
N
HP
A
I
R
N
AV
I
E
A
A
ERGLS
F
GA----PT
E
ME
V
K
M
A
Q
L
V
TELV
P
TM--DM
V
RMVN
SG
T
EA
T
M
S
A
I
R
LAR
GFTG-----
-
R
DKI
I
K
F
E
G
C
YHG
H
A
DCLLVKAG
SG
A
LT
L
GQPNSP
-
-----
-
GV
P
A
D
FAKHTLTC------TYNDLASVRAAFE-
-
QYPQEI
A
C
II
V
EPV
-
A
G
N
MN
CVPPL
PE
F
L
PG
LR
A
LCDE
F
G
A
LLI
I
DEV
MT
G
F-
R
VA
L
AG
A
QDYYGVE
PDL
T
C
L
G
K
I
I
G
GG
-
MP
V
G
A
FG
G
R
R
D
VM
D
A
LA
P
T
G
--
PVYQ
A
G
T
LS
GNP
I
A
M
AA
G
F
A
C
L
NEVAQPGVH
E
TLDELTT
RL
A
E
G
L
LE
A
A
E
fig|749531.3.peg.4457
Escherichia coli MS 69-1 (36-340/426)
IEK
A
D
G
AY
L
Y
D
V
D
G
KA
Y
I
D
YVG
SW
GPMVL
GH
N
HP
A
I
R
N
AV
I
E
A
A
ERGLS
F
GA----PT
E
ME
V
K
M
A
Q
L
V
TELV
P
TM--DM
V
RMVN
SG
T
EA
T
M
S
A
I
R
LAR
GFTG-----
-
R
DKI
I
K
F
E
G
C
YHG
H
A
DCLLVKAG
SG
A
LT
L
GQPNSP
-
-----
-
GV
P
A
D
FAKHTLTC------TYNDLASVRAAFE-
-
QYPQEI
A
C
II
V
EPV
-
A
G
N
MN
CVPPL
PE
F
L
PG
LR
A
LCDE
F
G
A
LLI
I
DEV
MT
G
F-
R
VA
L
AG
A
QDYYGVE
PDL
T
C
L
G
K
I
I
G
GG
-
MP
V
G
A
FG
G
R
R
D
VM
D
A
LA
P
T
G
--
PVYQ
A
G
T
LS
GNP
I
A
M
AA
G
F
A
C
L
NEVAQPGVH
E
TLDELTT
RL
A
E
G
L
LE
A
A
E
fig|585396.4.peg.160
Escherichia coli O111:H- str. 11128 (36-340/426)
IEK
A
D
G
AY
L
Y
D
V
D
G
KA
Y
I
D
YVG
SW
GPMVL
GH
N
HP
A
I
R
N
AV
I
E
A
A
ERGLS
F
GA----PT
E
ME
V
K
M
A
Q
L
V
TELV
P
TM--DM
V
RMVN
SG
T
EA
T
M
S
A
I
R
LAR
GFTG-----
-
R
DKI
I
K
F
E
G
C
YHG
H
A
DCLLVKAG
SG
A
LT
L
GQPNSP
-
-----
-
GV
P
A
D
FAKHTLTC------TYNDLASVRAAFE-
-
QYPQEI
A
C
II
V
EPV
-
A
G
N
MN
CVPPL
PE
F
L
PG
LR
A
LCDE
F
G
A
LLI
I
DEV
MT
G
F-
R
VA
L
AG
A
QDYYGVE
PDL
T
C
L
G
K
I
I
G
GG
-
MP
V
G
A
FG
G
R
R
D
VM
D
A
LA
P
T
G
--
PVYQ
A
G
T
LS
GNP
I
A
M
AA
G
F
A
C
L
NEVAQPGVH
E
TLDELTT
RL
A
E
G
L
LE
A
A
E
fig|573235.3.peg.160
Escherichia coli O26:H11 str. 11368 (36-340/426)
IEK
A
D
G
AY
L
Y
D
V
D
G
KA
Y
I
D
YVG
SW
GPMVL
GH
N
HP
A
I
R
N
AV
I
E
A
A
ERGLS
F
GA----PT
E
ME
V
K
M
A
Q
L
V
TELV
P
TM--DM
V
RMVN
SG
T
EA
T
M
S
A
I
R
LAR
GFTG-----
-
R
DKI
I
K
F
E
G
C
YHG
H
A
DCLLVKAG
SG
A
LT
L
GQPNSP
-
-----
-
GV
P
A
D
FAKHTLTC------TYNDLASVRAAFE-
-
QYPQEI
A
C
II
V
EPV
-
A
G
N
MN
CVPPL
PE
F
L
PG
LR
A
LCDE
F
G
A
LLI
I
DEV
MT
G
F-
R
VA
L
AG
A
QDYYGVE
PDL
T
C
L
G
K
I
I
G
GG
-
MP
V
G
A
FG
G
R
R
D
VM
D
A
LA
P
T
G
--
PVYQ
A
G
T
LS
GNP
I
A
M
AA
G
F
A
C
L
NEVAQPGVH
E
TLDELTT
RL
A
E
G
L
LE
A
A
E
fig|409438.11.peg.275
Escherichia coli SE11 (36-340/426)
IEK
A
D
G
AY
L
Y
D
V
D
G
KA
Y
I
D
YVG
SW
GPMVL
GH
N
HP
A
I
R
N
AV
I
E
A
A
ERGLS
F
GA----PT
E
ME
V
K
M
A
Q
L
V
TELV
P
TM--DM
V
RMVN
SG
T
EA
T
M
S
A
I
R
LAR
GFTG-----
-
R
DKI
I
K
F
E
G
C
YHG
H
A
DCLLVKAG
SG
A
LT
L
GQPNSP
-
-----
-
GV
P
A
D
FAKHTLTC------TYNDLASVRAAFE-
-
QYPQEI
A
C
II
V
EPV
-
A
G
N
MN
CVPPL
PE
F
L
PG
LR
A
LCDE
F
G
A
LLI
I
DEV
MT
G
F-
R
VA
L
AG
A
QDYYGVE
PDL
T
C
L
G
K
I
I
G
GG
-
MP
V
G
A
FG
G
R
R
D
VM
D
A
LA
P
T
G
--
PVYQ
A
G
T
LS
GNP
I
A
M
AA
G
F
A
C
L
NEVAQPGVH
E
TLDELTT
RL
A
E
G
L
LE
A
A
E
fig|656437.3.peg.222
Escherichia coli TA143 (36-340/426)
IEK
A
D
G
AY
L
Y
D
V
D
G
KA
Y
I
D
YVG
SW
GPMVL
GH
N
HP
A
I
R
N
AV
I
E
A
A
ERGLS
F
GA----PT
E
ME
V
K
M
A
Q
L
V
TELV
P
TM--DM
V
RMVN
SG
T
EA
T
M
S
A
I
R
LAR
GFTG-----
-
R
DKI
I
K
F
E
G
C
YHG
H
A
DCLLVKAG
SG
A
LT
L
GQPNSP
-
-----
-
GV
P
A
D
FAKHTLTC------TYNDLASVRAAFE-
-
QYPQEI
A
C
II
V
EPV
-
A
G
N
MN
CVPPL
PE
F
L
PG
LR
A
LCDE
F
G
A
LLI
I
DEV
MT
G
F-
R
VA
L
AG
A
QDYYGVE
PDL
T
C
L
G
K
I
I
G
GG
-
MP
V
G
A
FG
G
R
R
D
VM
D
A
LA
P
T
G
--
PVYQ
A
G
T
LS
GNP
I
A
M
AA
G
F
A
C
L
NEVAQPGVH
E
TLDELTT
RL
A
E
G
L
LE
A
A
E
fig|656440.3.peg.5246
Escherichia coli TA206 (36-340/426)
IEK
A
D
G
AY
L
Y
D
V
D
G
KA
Y
I
D
YVG
SW
GPMVL
GH
N
HP
A
I
R
N
AV
I
E
A
A
ERGLS
F
GA----PT
E
ME
V
K
M
A
Q
L
V
TELV
P
TM--DM
V
RMVN
SG
T
EA
T
M
S
A
I
R
LAR
GFTG-----
-
R
DKI
I
K
F
E
G
C
YHG
H
A
DCLLVKAG
SG
A
LT
L
GQPNSP
-
-----
-
GV
P
A
D
FAKHTLTC------TYNDLASVRAAFE-
-
QYPQEI
A
C
II
V
EPV
-
A
G
N
MN
CVPPL
PE
F
L
PG
LR
A
LCDE
F
G
A
LLI
I
DEV
MT
G
F-
R
VA
L
AG
A
QDYYGVE
PDL
T
C
L
G
K
I
I
G
GG
-
MP
V
G
A
FG
G
R
R
D
VM
D
A
LA
P
T
G
--
PVYQ
A
G
T
LS
GNP
I
A
M
AA
G
F
A
C
L
NEVAQPGVH
E
TLDELTT
RL
A
E
G
L
LE
A
A
E
fig|585056.7.peg.345
Escherichia coli UMN026 (36-340/426)
IEK
A
D
G
AY
L
Y
D
V
D
G
KA
Y
I
D
YVG
SW
GPMVL
GH
N
HP
A
I
R
N
AV
I
E
A
A
ERGLS
F
GA----PT
E
ME
V
K
M
A
Q
L
V
TELV
P
TM--DM
V
RMVN
SG
T
EA
T
M
S
A
I
R
LAR
GFTG-----
-
R
DKI
I
K
F
E
G
C
YHG
H
A
DCLLVKAG
SG
A
LT
L
GQPNSP
-
-----
-
GV
P
A
D
FAKHTLTC------TYNDLASVRAAFE-
-
QYPQEI
A
C
II
V
EPV
-
A
G
N
MN
CVPPL
PE
F
L
PG
LR
A
LCDE
F
G
A
LLI
I
DEV
MT
G
F-
R
VA
L
AG
A
QDYYGVE
PDL
T
C
L
G
K
I
I
G
GG
-
MP
V
G
A
FG
G
R
R
D
VM
D
A
LA
P
T
G
--
PVYQ
A
G
T
LS
GNP
I
A
M
AA
G
F
A
C
L
NEVAQPGVH
E
TLDELTT
RL
A
E
G
L
LE
A
A
E
fig|550676.3.peg.4839
Escherichia coli B185 (36-340/426)
IEK
A
D
G
AY
L
Y
D
V
D
G
KA
Y
I
D
YVG
SW
GPMVL
GH
N
HP
A
I
R
N
AV
I
E
A
A
ERGLS
F
GA----PT
E
ME
V
K
M
A
Q
L
V
TELV
P
TM--DM
V
RMVN
SG
T
EA
T
M
S
A
I
R
LAR
GFTG-----
-
R
DKI
I
K
F
E
G
C
YHG
H
A
DCLLVKAG
SG
A
LT
L
GQPNSP
-
-----
-
GV
P
A
D
FAKHTLTC------TFNDLASVRAAFE-
-
QYPQEI
A
C
II
V
EPV
-
A
G
N
MN
CVPPL
PE
F
L
PG
LR
A
LCDE
F
G
A
LLI
I
DEV
MT
G
F-
R
VA
L
AG
A
QDYYGVV
PDL
T
C
L
G
K
I
I
G
GG
-
MP
V
G
A
FG
G
R
R
D
VM
D
A
LA
P
T
G
--
PVYQ
A
G
T
LS
GNP
I
A
M
AA
G
F
A
C
L
NEVAQPGVH
E
TLDELTT
RL
A
E
G
L
LE
A
A
E
fig|749548.3.peg.4187
Escherichia coli MS 196-1 (36-340/426)
IEK
A
D
G
AY
L
Y
D
V
D
G
KA
Y
I
D
YVG
SW
GPMVL
GH
N
HP
A
I
R
N
AV
I
E
A
A
ERGLS
F
GA----PT
E
ME
V
K
M
A
Q
L
V
TELV
P
TM--DM
V
RMVN
SG
T
EA
T
M
S
A
I
R
LAR
GFTG-----
-
R
DKI
I
K
F
E
G
C
YHG
H
A
DCLLVKAG
SG
A
LT
L
GQPNSP
-
-----
-
GV
P
A
D
FAKHTLTC------TYNDLASVRAAFE-
-
QYPQEI
A
C
II
V
EPV
-
A
G
N
MN
CVPPL
PE
F
L
PG
LR
A
LCDE
F
G
A
LLI
I
DEV
MT
G
F-
R
VA
L
AG
A
QDYYGVV
PDL
T
C
L
G
K
I
I
G
GG
-
MP
V
G
A
FG
G
R
R
D
VM
D
A
LA
P
T
G
--
PVYQ
A
G
T
LS
GNP
I
A
R
AA
G
F
A
C
L
NEVAQPGVH
E
TLDELTT
RL
A
E
G
L
LE
A
A
E
fig|656419.3.peg.323
Escherichia coli M718 (36-340/426)
IEK
A
D
G
AY
L
Y
D
V
D
G
KA
Y
I
D
YVG
SW
GPMVL
GH
N
HP
A
I
R
N
AV
I
E
A
A
ERGLS
F
GA----PT
E
ME
V
K
M
A
Q
L
V
TELV
P
TM--DM
V
RMVN
SG
T
EA
T
M
S
A
I
R
LAR
GFTG-----
-
R
DKI
I
K
F
E
G
C
YHG
H
A
DCLLVKAG
SG
A
LT
L
GQPNSP
-
-----
-
GV
P
A
D
FAKHTLTC------TYNDLASVRAAFE-
-
QYPQEI
A
C
II
V
EPV
-
A
G
N
MN
CVPPL
P
D
F
L
PG
LR
A
LCDE
F
G
A
LLI
I
DEV
MT
G
F-
R
VA
L
AG
A
QDYYGVV
PDL
T
C
L
G
K
I
I
G
GG
-
MP
V
G
A
FG
G
R
R
D
VM
D
A
LA
P
T
G
--
PVYQ
A
G
T
LS
GNP
I
A
M
AA
G
F
A
C
L
NEVAQPGVH
E
TLDELTT
RL
A
E
G
L
LE
A
A
E
fig|562.371.peg.888
Escherichia coli 1044A (36-340/426)
IEK
A
D
G
AY
L
Y
D
V
D
G
KA
Y
I
D
YVG
SW
GPMVL
GH
N
HP
A
I
R
N
AV
I
E
A
A
ERGLS
F
GA----PT
E
ME
V
K
M
A
Q
L
V
TELV
P
TM--DM
V
RMVN
SG
T
EA
T
M
S
A
I
R
LAR
GFTG-----
-
R
DKI
I
K
F
E
G
C
YHG
H
A
DCLLVKAG
SG
A
LT
L
GQPNSP
-
-----
-
GV
P
A
D
FAKHTLTC------TYNDLASVRAAFE-
-
QYPQEI
A
C
II
V
EPV
-
A
G
N
MN
CVPPL
P
D
F
L
PG
LR
A
LCDE
F
G
A
LLI
I
DEV
MT
G
F-
R
VA
L
AG
A
QDYYGVE
PDL
T
C
L
G
K
I
I
G
GG
-
MP
V
G
A
FG
G
R
R
D
VM
D
A
LA
P
T
G
--
PVYQ
A
G
T
LS
GNP
I
A
M
AA
G
F
A
C
L
NEVAQPGVH
E
TLDELTT
RL
A
E
G
L
LE
A
A
E
fig|562.373.peg.2105
Escherichia coli 1125A (36-340/426)
IEK
A
D
G
AY
L
Y
D
V
D
G
KA
Y
I
D
YVG
SW
GPMVL
GH
N
HP
A
I
R
N
AV
I
E
A
A
ERGLS
F
GA----PT
E
ME
V
K
M
A
Q
L
V
TELV
P
TM--DM
V
RMVN
SG
T
EA
T
M
S
A
I
R
LAR
GFTG-----
-
R
DKI
I
K
F
E
G
C
YHG
H
A
DCLLVKAG
SG
A
LT
L
GQPNSP
-
-----
-
GV
P
A
D
FAKHTLTC------TYNDLASVRAAFE-
-
QYPQEI
A
C
II
V
EPV
-
A
G
N
MN
CVPPL
P
D
F
L
PG
LR
A
LCDE
F
G
A
LLI
I
DEV
MT
G
F-
R
VA
L
AG
A
QDYYGVE
PDL
T
C
L
G
K
I
I
G
GG
-
MP
V
G
A
FG
G
R
R
D
VM
D
A
LA
P
T
G
--
PVYQ
A
G
T
LS
GNP
I
A
M
AA
G
F
A
C
L
NEVAQPGVH
E
TLDELTT
RL
A
E
G
L
LE
A
A
E
fig|562.372.peg.2955
Escherichia coli 1212A (36-340/426)
IEK
A
D
G
AY
L
Y
D
V
D
G
KA
Y
I
D
YVG
SW
GPMVL
GH
N
HP
A
I
R
N
AV
I
E
A
A
ERGLS
F
GA----PT
E
ME
V
K
M
A
Q
L
V
TELV
P
TM--DM
V
RMVN
SG
T
EA
T
M
S
A
I
R
LAR
GFTG-----
-
R
DKI
I
K
F
E
G
C
YHG
H
A
DCLLVKAG
SG
A
LT
L
GQPNSP
-
-----
-
GV
P
A
D
FAKHTLTC------TYNDLASVRAAFE-
-
QYPQEI
A
C
II
V
EPV
-
A
G
N
MN
CVPPL
P
D
F
L
PG
LR
A
LCDE
F
G
A
LLI
I
DEV
MT
G
F-
R
VA
L
AG
A
QDYYGVE
PDL
T
C
L
G
K
I
I
G
GG
-
MP
V
G
A
FG
G
R
R
D
VM
D
A
LA
P
T
G
--
PVYQ
A
G
T
LS
GNP
I
A
M
AA
G
F
A
C
L
NEVAQPGVH
E
TLDELTT
RL
A
E
G
L
LE
A
A
E
fig|562.374.peg.2146
Escherichia coli 536A (36-340/426)
IEK
A
D
G
AY
L
Y
D
V
D
G
KA
Y
I
D
YVG
SW
GPMVL
GH
N
HP
A
I
R
N
AV
I
E
A
A
ERGLS
F
GA----PT
E
ME
V
K
M
A
Q
L
V
TELV
P
TM--DM
V
RMVN
SG
T
EA
T
M
S
A
I
R
LAR
GFTG-----
-
R
DKI
I
K
F
E
G
C
YHG
H
A
DCLLVKAG
SG
A
LT
L
GQPNSP
-
-----
-
GV
P
A
D
FAKHTLTC------TYNDLASVRAAFE-
-
QYPQEI
A
C
II
V
EPV
-
A
G
N
MN
CVPPL
P
D
F
L
PG
LR
A
LCDE
F
G
A
LLI
I
DEV
MT
G
F-
R
VA
L
AG
A
QDYYGVE
PDL
T
C
L
G
K
I
I
G
GG
-
MP
V
G
A
FG
G
R
R
D
VM
D
A
LA
P
T
G
--
PVYQ
A
G
T
LS
GNP
I
A
M
AA
G
F
A
C
L
NEVAQPGVH
E
TLDELTT
RL
A
E
G
L
LE
A
A
E
fig|83334.1.peg.246
Escherichia coli O157:H7 (36-340/426)
IEK
A
D
G
AY
L
Y
D
V
D
G
KA
Y
I
D
YVG
SW
GPMVL
GH
N
HP
A
I
R
N
AV
I
E
A
A
ERGLS
F
GA----PT
E
ME
V
K
M
A
Q
L
V
TELV
P
TM--DM
V
RMVN
SG
T
EA
T
M
S
A
I
R
LAR
GFTG-----
-
R
DKI
I
K
F
E
G
C
YHG
H
A
DCLLVKAG
SG
A
LT
L
GQPNSP
-
-----
-
GV
P
A
D
FAKHTLTC------TYNDLASVRAAFE-
-
QYPQEI
A
C
II
V
EPV
-
A
G
N
MN
CVPPL
P
D
F
L
PG
LR
A
LCDE
F
G
A
LLI
I
DEV
MT
G
F-
R
VA
L
AG
A
QDYYGVE
PDL
T
C
L
G
K
I
I
G
GG
-
MP
V
G
A
FG
G
R
R
D
VM
D
A
LA
P
T
G
--
PVYQ
A
G
T
LS
GNP
I
A
M
AA
G
F
A
C
L
NEVAQPGVH
E
TLDELTT
RL
A
E
G
L
LE
A
A
E
fig|155864.1.peg.158
Escherichia coli O157:H7 EDL933 (36-340/426)
IEK
A
D
G
AY
L
Y
D
V
D
G
KA
Y
I
D
YVG
SW
GPMVL
GH
N
HP
A
I
R
N
AV
I
E
A
A
ERGLS
F
GA----PT
E
ME
V
K
M
A
Q
L
V
TELV
P
TM--DM
V
RMVN
SG
T
EA
T
M
S
A
I
R
LAR
GFTG-----
-
R
DKI
I
K
F
E
G
C
YHG
H
A
DCLLVKAG
SG
A
LT
L
GQPNSP
-
-----
-
GV
P
A
D
FAKHTLTC------TYNDLASVRAAFE-
-
QYPQEI
A
C
II
V
EPV
-
A
G
N
MN
CVPPL
P
D
F
L
PG
LR
A
LCDE
F
G
A
LLI
I
DEV
MT
G
F-
R
VA
L
AG
A
QDYYGVE
PDL
T
C
L
G
K
I
I
G
GG
-
MP
V
G
A
FG
G
R
R
D
VM
D
A
LA
P
T
G
--
PVYQ
A
G
T
LS
GNP
I
A
M
AA
G
F
A
C
L
NEVAQPGVH
E
TLDELTT
RL
A
E
G
L
LE
A
A
E
fig|155864.8.peg.159
Escherichia coli O157:H7 EDL933 (36-340/426)
IEK
A
D
G
AY
L
Y
D
V
D
G
KA
Y
I
D
YVG
SW
GPMVL
GH
N
HP
A
I
R
N
AV
I
E
A
A
ERGLS
F
GA----PT
E
ME
V
K
M
A
Q
L
V
TELV
P
TM--DM
V
RMVN
SG
T
EA
T
M
S
A
I
R
LAR
GFTG-----
-
R
DKI
I
K
F
E
G
C
YHG
H
A
DCLLVKAG
SG
A
LT
L
GQPNSP
-
-----
-
GV
P
A
D
FAKHTLTC------TYNDLASVRAAFE-
-
QYPQEI
A
C
II
V
EPV
-
A
G
N
MN
CVPPL
P
D
F
L
PG
LR
A
LCDE
F
G
A
LLI
I
DEV
MT
G
F-
R
VA
L
AG
A
QDYYGVE
PDL
T
C
L
G
K
I
I
G
GG
-
MP
V
G
A
FG
G
R
R
D
VM
D
A
LA
P
T
G
--
PVYQ
A
G
T
LS
GNP
I
A
M
AA
G
F
A
C
L
NEVAQPGVH
E
TLDELTT
RL
A
E
G
L
LE
A
A
E
fig|444454.5.peg.4622
Escherichia coli O157:H7 str. EC4024 (36-340/426)
IEK
A
D
G
AY
L
Y
D
V
D
G
KA
Y
I
D
YVG
SW
GPMVL
GH
N
HP
A
I
R
N
AV
I
E
A
A
ERGLS
F
GA----PT
E
ME
V
K
M
A
Q
L
V
TELV
P
TM--DM
V
RMVN
SG
T
EA
T
M
S
A
I
R
LAR
GFTG-----
-
R
DKI
I
K
F
E
G
C
YHG
H
A
DCLLVKAG
SG
A
LT
L
GQPNSP
-
-----
-
GV
P
A
D
FAKHTLTC------TYNDLASVRAAFE-
-
QYPQEI
A
C
II
V
EPV
-
A
G
N
MN
CVPPL
P
D
F
L
PG
LR
A
LCDE
F
G
A
LLI
I
DEV
MT
G
F-
R
VA
L
AG
A
QDYYGVE
PDL
T
C
L
G
K
I
I
G
GG
-
MP
V
G
A
FG
G
R
R
D
VM
D
A
LA
P
T
G
--
PVYQ
A
G
T
LS
GNP
I
A
M
AA
G
F
A
C
L
NEVAQPGVH
E
TLDELTT
RL
A
E
G
L
LE
A
A
E
fig|444449.5.peg.4073
Escherichia coli O157:H7 str. EC4042 (36-340/426)
IEK
A
D
G
AY
L
Y
D
V
D
G
KA
Y
I
D
YVG
SW
GPMVL
GH
N
HP
A
I
R
N
AV
I
E
A
A
ERGLS
F
GA----PT
E
ME
V
K
M
A
Q
L
V
TELV
P
TM--DM
V
RMVN
SG
T
EA
T
M
S
A
I
R
LAR
GFTG-----
-
R
DKI
I
K
F
E
G
C
YHG
H
A
DCLLVKAG
SG
A
LT
L
GQPNSP
-
-----
-
GV
P
A
D
FAKHTLTC------TYNDLASVRAAFE-
-
QYPQEI
A
C
II
V
EPV
-
A
G
N
MN
CVPPL
P
D
F
L
PG
LR
A
LCDE
F
G
A
LLI
I
DEV
MT
G
F-
R
VA
L
AG
A
QDYYGVE
PDL
T
C
L
G
K
I
I
G
GG
-
MP
V
G
A
FG
G
R
R
D
VM
D
A
LA
P
T
G
--
PVYQ
A
G
T
LS
GNP
I
A
M
AA
G
F
A
C
L
NEVAQPGVH
E
TLDELTT
RL
A
E
G
L
LE
A
A
E
fig|444448.5.peg.2830
Escherichia coli O157:H7 str. EC4045 (36-340/426)
IEK
A
D
G
AY
L
Y
D
V
D
G
KA
Y
I
D
YVG
SW
GPMVL
GH
N
HP
A
I
R
N
AV
I
E
A
A
ERGLS
F
GA----PT
E
ME
V
K
M
A
Q
L
V
TELV
P
TM--DM
V
RMVN
SG
T
EA
T
M
S
A
I
R
LAR
GFTG-----
-
R
DKI
I
K
F
E
G
C
YHG
H
A
DCLLVKAG
SG
A
LT
L
GQPNSP
-
-----
-
GV
P
A
D
FAKHTLTC------TYNDLASVRAAFE-
-
QYPQEI
A
C
II
V
EPV
-
A
G
N
MN
CVPPL
P
D
F
L
PG
LR
A
LCDE
F
G
A
LLI
I
DEV
MT
G
F-
R
VA
L
AG
A
QDYYGVE
PDL
T
C
L
G
K
I
I
G
GG
-
MP
V
G
A
FG
G
R
R
D
VM
D
A
LA
P
T
G
--
PVYQ
A
G
T
LS
GNP
I
A
M
AA
G
F
A
C
L
NEVAQPGVH
E
TLDELTT
RL
A
E
G
L
LE
A
A
E
fig|444453.5.peg.3433
Escherichia coli O157:H7 str. EC4076 (36-340/426)
IEK
A
D
G
AY
L
Y
D
V
D
G
KA
Y
I
D
YVG
SW
GPMVL
GH
N
HP
A
I
R
N
AV
I
E
A
A
ERGLS
F
GA----PT
E
ME
V
K
M
A
Q
L
V
TELV
P
TM--DM
V
RMVN
SG
T
EA
T
M
S
A
I
R
LAR
GFTG-----
-
R
DKI
I
K
F
E
G
C
YHG
H
A
DCLLVKAG
SG
A
LT
L
GQPNSP
-
-----
-
GV
P
A
D
FAKHTLTC------TYNDLASVRAAFE-
-
QYPQEI
A
C
II
V
EPV
-
A
G
N
MN
CVPPL
P
D
F
L
PG
LR
A
LCDE
F
G
A
LLI
I
DEV
MT
G
F-
R
VA
L
AG
A
QDYYGVE
PDL
T
C
L
G
K
I
I
G
GG
-
MP
V
G
A
FG
G
R
R
D
VM
D
A
LA
P
T
G
--
PVYQ
A
G
T
LS
GNP
I
A
M
AA
G
F
A
C
L
NEVAQPGVH
E
TLDELTT
RL
A
E
G
L
LE
A
A
E
fig|444452.5.peg.4279
Escherichia coli O157:H7 str. EC4113 (36-340/426)
IEK
A
D
G
AY
L
Y
D
V
D
G
KA
Y
I
D
YVG
SW
GPMVL
GH
N
HP
A
I
R
N
AV
I
E
A
A
ERGLS
F
GA----PT
E
ME
V
K
M
A
Q
L
V
TELV
P
TM--DM
V
RMVN
SG
T
EA
T
M
S
A
I
R
LAR
GFTG-----
-
R
DKI
I
K
F
E
G
C
YHG
H
A
DCLLVKAG
SG
A
LT
L
GQPNSP
-
-----
-
GV
P
A
D
FAKHTLTC------TYNDLASVRAAFE-
-
QYPQEI
A
C
II
V
EPV
-
A
G
N
MN
CVPPL
P
D
F
L
PG
LR
A
LCDE
F
G
A
LLI
I
DEV
MT
G
F-
R
VA
L
AG
A
QDYYGVE
PDL
T
C
L
G
K
I
I
G
GG
-
MP
V
G
A
FG
G
R
R
D
VM
D
A
LA
P
T
G
--
PVYQ
A
G
T
LS
GNP
I
A
M
AA
G
F
A
C
L
NEVAQPGVH
E
TLDELTT
RL
A
E
G
L
LE
A
A
E
fig|444450.8.peg.300
Escherichia coli O157:H7 str. EC4115 (36-340/426)
IEK
A
D
G
AY
L
Y
D
V
D
G
KA
Y
I
D
YVG
SW
GPMVL
GH
N
HP
A
I
R
N
AV
I
E
A
A
ERGLS
F
GA----PT
E
ME
V
K
M
A
Q
L
V
TELV
P
TM--DM
V
RMVN
SG
T
EA
T
M
S
A
I
R
LAR
GFTG-----
-
R
DKI
I
K
F
E
G
C
YHG
H
A
DCLLVKAG
SG
A
LT
L
GQPNSP
-
-----
-
GV
P
A
D
FAKHTLTC------TYNDLASVRAAFE-
-
QYPQEI
A
C
II
V
EPV
-
A
G
N
MN
CVPPL
P
D
F
L
PG
LR
A
LCDE
F
G
A
LLI
I
DEV
MT
G
F-
R
VA
L
AG
A
QDYYGVE
PDL
T
C
L
G
K
I
I
G
GG
-
MP
V
G
A
FG
G
R
R
D
VM
D
A
LA
P
T
G
--
PVYQ
A
G
T
LS
GNP
I
A
M
AA
G
F
A
C
L
NEVAQPGVH
E
TLDELTT
RL
A
E
G
L
LE
A
A
E
fig|444451.5.peg.4468
Escherichia coli O157:H7 str. EC4196 (36-340/426)
IEK
A
D
G
AY
L
Y
D
V
D
G
KA
Y
I
D
YVG
SW
GPMVL
GH
N
HP
A
I
R
N
AV
I
E
A
A
ERGLS
F
GA----PT
E
ME
V
K
M
A
Q
L
V
TELV
P
TM--DM
V
RMVN
SG
T
EA
T
M
S
A
I
R
LAR
GFTG-----
-
R
DKI
I
K
F
E
G
C
YHG
H
A
DCLLVKAG
SG
A
LT
L
GQPNSP
-
-----
-
GV
P
A
D
FAKHTLTC------TYNDLASVRAAFE-
-
QYPQEI
A
C
II
V
EPV
-
A
G
N
MN
CVPPL
P
D
F
L
PG
LR
A
LCDE
F
G
A
LLI
I
DEV
MT
G
F-
R
VA
L
AG
A
QDYYGVE
PDL
T
C
L
G
K
I
I
G
GG
-
MP
V
G
A
FG
G
R
R
D
VM
D
A
LA
P
T
G
--
PVYQ
A
G
T
LS
GNP
I
A
M
AA
G
F
A
C
L
NEVAQPGVH
E
TLDELTT
RL
A
E
G
L
LE
A
A
E
fig|444447.5.peg.3005
Escherichia coli O157:H7 str. EC4206 (36-340/426)
IEK
A
D
G
AY
L
Y
D
V
D
G
KA
Y
I
D
YVG
SW
GPMVL
GH
N
HP
A
I
R
N
AV
I
E
A
A
ERGLS
F
GA----PT
E
ME
V
K
M
A
Q
L
V
TELV
P
TM--DM
V
RMVN
SG
T
EA
T
M
S
A
I
R
LAR
GFTG-----
-
R
DKI
I
K
F
E
G
C
YHG
H
A
DCLLVKAG
SG
A
LT
L
GQPNSP
-
-----
-
GV
P
A
D
FAKHTLTC------TYNDLASVRAAFE-
-
QYPQEI
A
C
II
V
EPV
-
A
G
N
MN
CVPPL
P
D
F
L
PG
LR
A
LCDE
F
G
A
LLI
I
DEV
MT
G
F-
R
VA
L
AG
A
QDYYGVE
PDL
T
C
L
G
K
I
I
G
GG
-
MP
V
G
A
FG
G
R
R
D
VM
D
A
LA
P
T
G
--
PVYQ
A
G
T
LS
GNP
I
A
M
AA
G
F
A
C
L
NEVAQPGVH
E
TLDELTT
RL
A
E
G
L
LE
A
A
E
fig|478004.5.peg.2532
Escherichia coli O157:H7 str. EC4401 (36-340/426)
IEK
A
D
G
AY
L
Y
D
V
D
G
KA
Y
I
D
YVG
SW
GPMVL
GH
N
HP
A
I
R
N
AV
I
E
A
A
ERGLS
F
GA----PT
E
ME
V
K
M
A
Q
L
V
TELV
P
TM--DM
V
RMVN
SG
T
EA
T
M
S
A
I
R
LAR
GFTG-----
-
R
DKI
I
K
F
E
G
C
YHG
H
A
DCLLVKAG
SG
A
LT
L
GQPNSP
-
-----
-
GV
P
A
D
FAKHTLTC------TYNDLASVRAAFE-
-
QYPQEI
A
C
II
V
EPV
-
A
G
N
MN
CVPPL
P
D
F
L
PG
LR
A
LCDE
F
G
A
LLI
I
DEV
MT
G
F-
R
VA
L
AG
A
QDYYGVE
PDL
T
C
L
G
K
I
I
G
GG
-
MP
V
G
A
FG
G
R
R
D
VM
D
A
LA
P
T
G
--
PVYQ
A
G
T
LS
GNP
I
A
M
AA
G
F
A
C
L
NEVAQPGVH
E
TLDELTT
RL
A
E
G
L
LE
A
A
E
fig|478005.5.peg.4176
Escherichia coli O157:H7 str. EC4486 (36-340/426)
IEK
A
D
G
AY
L
Y
D
V
D
G
KA
Y
I
D
YVG
SW
GPMVL
GH
N
HP
A
I
R
N
AV
I
E
A
A
ERGLS
F
GA----PT
E
ME
V
K
M
A
Q
L
V
TELV
P
TM--DM
V
RMVN
SG
T
EA
T
M
S
A
I
R
LAR
GFTG-----
-
R
DKI
I
K
F
E
G
C
YHG
H
A
DCLLVKAG
SG
A
LT
L
GQPNSP
-
-----
-
GV
P
A
D
FAKHTLTC------TYNDLASVRAAFE-
-
QYPQEI
A
C
II
V
EPV
-
A
G
N
MN
CVPPL
P
D
F
L
PG
LR
A
LCDE
F
G
A
LLI
I
DEV
MT
G
F-
R
VA
L
AG
A
QDYYGVE
PDL
T
C
L
G
K
I
I
G
GG
-
MP
V
G
A
FG
G
R
R
D
VM
D
A
LA
P
T
G
--
PVYQ
A
G
T
LS
GNP
I
A
M
AA
G
F
A
C
L
NEVAQPGVH
E
TLDELTT
RL
A
E
G
L
LE
A
A
E
fig|478006.5.peg.4653
Escherichia coli O157:H7 str. EC4501 (36-340/426)
IEK
A
D
G
AY
L
Y
D
V
D
G
KA
Y
I
D
YVG
SW
GPMVL
GH
N
HP
A
I
R
N
AV
I
E
A
A
ERGLS
F
GA----PT
E
ME
V
K
M
A
Q
L
V
TELV
P
TM--DM
V
RMVN
SG
T
EA
T
M
S
A
I
R
LAR
GFTG-----
-
R
DKI
I
K
F
E
G
C
YHG
H
A
DCLLVKAG
SG
A
LT
L
GQPNSP
-
-----
-
GV
P
A
D
FAKHTLTC------TYNDLASVRAAFE-
-
QYPQEI
A
C
II
V
EPV
-
A
G
N
MN
CVPPL
P
D
F
L
PG
LR
A
LCDE
F
G
A
LLI
I
DEV
MT
G
F-
R
VA
L
AG
A
QDYYGVE
PDL
T
C
L
G
K
I
I
G
GG
-
MP
V
G
A
FG
G
R
R
D
VM
D
A
LA
P
T
G
--
PVYQ
A
G
T
LS
GNP
I
A
M
AA
G
F
A
C
L
NEVAQPGVH
E
TLDELTT
RL
A
E
G
L
LE
A
A
E
fig|478007.5.peg.4887
Escherichia coli O157:H7 str. EC508 (36-340/426)
IEK
A
D
G
AY
L
Y
D
V
D
G
KA
Y
I
D
YVG
SW
GPMVL
GH
N
HP
A
I
R
N
AV
I
E
A
A
ERGLS
F
GA----PT
E
ME
V
K
M
A
Q
L
V
TELV
P
TM--DM
V
RMVN
SG
T
EA
T
M
S
A
I
R
LAR
GFTG-----
-
R
DKI
I
K
F
E
G
C
YHG
H
A
DCLLVKAG
SG
A
LT
L
GQPNSP
-
-----
-
GV
P
A
D
FAKHTLTC------TYNDLASVRAAFE-
-
QYPQEI
A
C
II
V
EPV
-
A
G
N
MN
CVPPL
P
D
F
L
PG
LR
A
LCDE
F
G
A
LLI
I
DEV
MT
G
F-
R
VA
L
AG
A
QDYYGVE
PDL
T
C
L
G
K
I
I
G
GG
-
MP
V
G
A
FG
G
R
R
D
VM
D
A
LA
P
T
G
--
PVYQ
A
G
T
LS
GNP
I
A
M
AA
G
F
A
C
L
NEVAQPGVH
E
TLDELTT
RL
A
E
G
L
LE
A
A
E
fig|478008.5.peg.4351
Escherichia coli O157:H7 str. EC869 (36-340/426)
IEK
A
D
G
AY
L
Y
D
V
D
G
KA
Y
I
D
YVG
SW
GPMVL
GH
N
HP
A
I
R
N
AV
I
E
A
A
ERGLS
F
GA----PT
E
ME
V
K
M
A
Q
L
V
TELV
P
TM--DM
V
RMVN
SG
T
EA
T
M
S
A
I
R
LAR
GFTG-----
-
R
DKI
I
K
F
E
G
C
YHG
H
A
DCLLVKAG
SG
A
LT
L
GQPNSP
-
-----
-
GV
P
A
D
FAKHTLTC------TYNDLASVRAAFE-
-
QYPQEI
A
C
II
V
EPV
-
A
G
N
MN
CVPPL
P
D
F
L
PG
LR
A
LCDE
F
G
A
LLI
I
DEV
MT
G
F-
R
VA
L
AG
A
QDYYGVE
PDL
T
C
L
G
K
I
I
G
GG
-
MP
V
G
A
FG
G
R
R
D
VM
D
A
LA
P
T
G
--
PVYQ
A
G
T
LS
GNP
I
A
M
AA
G
F
A
C
L
NEVAQPGVH
E
TLDELTT
RL
A
E
G
L
LE
A
A
E
fig|637388.3.peg.3997
Escherichia coli O157:H7 str. FRIK2000 (36-340/426)
IEK
A
D
G
AY
L
Y
D
V
D
G
KA
Y
I
D
YVG
SW
GPMVL
GH
N
HP
A
I
R
N
AV
I
E
A
A
ERGLS
F
GA----PT
E
ME
V
K
M
A
Q
L
V
TELV
P
TM--DM
V
RMVN
SG
T
EA
T
M
S
A
I
R
LAR
GFTG-----
-
R
DKI
I
K
F
E
G
C
YHG
H
A
DCLLVKAG
SG
A
LT
L
GQPNSP
-
-----
-
GV
P
A
D
FAKHTLTC------TYNDLASVRAAFE-
-
QYPQEI
A
C
II
V
EPV
-
A
G
N
MN
CVPPL
P
D
F
L
PG
LR
A
LCDE
F
G
A
LLI
I
DEV
MT
G
F-
R
VA
L
AG
A
QDYYGVE
PDL
T
C
L
G
K
I
I
G
GG
-
MP
V
G
A
FG
G
R
R
D
VM
D
A
LA
P
T
G
--
PVYQ
A
G
T
LS
GNP
I
A
M
AA
G
F
A
C
L
NEVAQPGVH
E
TLDELTT
RL
A
E
G
L
LE
A
A
E
fig|570506.3.peg.1161
Escherichia coli O157:H7 str. FRIK966 (36-340/426)
IEK
A
D
G
AY
L
Y
D
V
D
G
KA
Y
I
D
YVG
SW
GPMVL
GH
N
HP
A
I
R
N
AV
I
E
A
A
ERGLS
F
GA----PT
E
ME
V
K
M
A
Q
L
V
TELV
P
TM--DM
V
RMVN
SG
T
EA
T
M
S
A
I
R
LAR
GFTG-----
-
R
DKI
I
K
F
E
G
C
YHG
H
A
DCLLVKAG
SG
A
LT
L
GQPNSP
-
-----
-
GV
P
A
D
FAKHTLTC------TYNDLASVRAAFE-
-
QYPQEI
A
C
II
V
EPV
-
A
G
N
MN
CVPPL
P
D
F
L
PG
LR
A
LCDE
F
G
A
LLI
I
DEV
MT
G
F-
R
VA
L
AG
A
QDYYGVE
PDL
T
C
L
G
K
I
I
G
GG
-
MP
V
G
A
FG
G
R
R
D
VM
D
A
LA
P
T
G
--
PVYQ
A
G
T
LS
GNP
I
A
M
AA
G
F
A
C
L
NEVAQPGVH
E
TLDELTT
RL
A
E
G
L
LE
A
A
E
fig|386585.9.peg.258
Escherichia coli O157:H7 str. Sakai (36-340/426)
IEK
A
D
G
AY
L
Y
D
V
D
G
KA
Y
I
D
YVG
SW
GPMVL
GH
N
HP
A
I
R
N
AV
I
E
A
A
ERGLS
F
GA----PT
E
ME
V
K
M
A
Q
L
V
TELV
P
TM--DM
V
RMVN
SG
T
EA
T
M
S
A
I
R
LAR
GFTG-----
-
R
DKI
I
K
F
E
G
C
YHG
H
A
DCLLVKAG
SG
A
LT
L
GQPNSP
-
-----
-
GV
P
A
D
FAKHTLTC------TYNDLASVRAAFE-
-
QYPQEI
A
C
II
V
EPV
-
A
G
N
MN
CVPPL
P
D
F
L
PG
LR
A
LCDE
F
G
A
LLI
I
DEV
MT
G
F-
R
VA
L
AG
A
QDYYGVE
PDL
T
C
L
G
K
I
I
G
GG
-
MP
V
G
A
FG
G
R
R
D
VM
D
A
LA
P
T
G
--
PVYQ
A
G
T
LS
GNP
I
A
M
AA
G
F
A
C
L
NEVAQPGVH
E
TLDELTT
RL
A
E
G
L
LE
A
A
E
fig|544404.4.peg.162
Escherichia coli O157:H7 str. TW14359 (36-340/426)
IEK
A
D
G
AY
L
Y
D
V
D
G
KA
Y
I
D
YVG
SW
GPMVL
GH
N
HP
A
I
R
N
AV
I
E
A
A
ERGLS
F
GA----PT
E
ME
V
K
M
A
Q
L
V
TELV
P
TM--DM
V
RMVN
SG
T
EA
T
M
S
A
I
R
LAR
GFTG-----
-
R
DKI
I
K
F
E
G
C
YHG
H
A
DCLLVKAG
SG
A
LT
L
GQPNSP
-
-----
-
GV
P
A
D
FAKHTLTC------TYNDLASVRAAFE-
-
QYPQEI
A
C
II
V
EPV
-
A
G
N
MN
CVPPL
P
D
F
L
PG
LR
A
LCDE
F
G
A
LLI
I
DEV
MT
G
F-
R
VA
L
AG
A
QDYYGVE
PDL
T
C
L
G
K
I
I
G
GG
-
MP
V
G
A
FG
G
R
R
D
VM
D
A
LA
P
T
G
--
PVYQ
A
G
T
LS
GNP
I
A
M
AA
G
F
A
C
L
NEVAQPGVH
E
TLDELTT
RL
A
E
G
L
LE
A
A
E
fig|502346.5.peg.1105
Escherichia coli O157:H7 str. TW14588 (36-340/426)
IEK
A
D
G
AY
L
Y
D
V
D
G
KA
Y
I
D
YVG
SW
GPMVL
GH
N
HP
A
I
R
N
AV
I
E
A
A
ERGLS
F
GA----PT
E
ME
V
K
M
A
Q
L
V
TELV
P
TM--DM
V
RMVN
SG
T
EA
T
M
S
A
I
R
LAR
GFTG-----
-
R
DKI
I
K
F
E
G
C
YHG
H
A
DCLLVKAG
SG
A
LT
L
GQPNSP
-
-----
-
GV
P
A
D
FAKHTLTC------TYNDLASVRAAFE-
-
QYPQEI
A
C
II
V
EPV
-
A
G
N
MN
CVPPL
P
D
F
L
PG
LR
A
LCDE
F
G
A
LLI
I
DEV
MT
G
F-
R
VA
L
AG
A
QDYYGVE
PDL
T
C
L
G
K
I
I
G
GG
-
MP
V
G
A
FG
G
R
R
D
VM
D
A
LA
P
T
G
--
PVYQ
A
G
T
LS
GNP
I
A
M
AA
G
F
A
C
L
NEVAQPGVH
E
TLDELTT
RL
A
E
G
L
LE
A
A
E
fig|701177.3.peg.160
Escherichia coli O55:H7 str. CB9615 (36-340/426)
IEK
A
D
G
AY
L
Y
D
V
D
G
KA
Y
I
D
YVG
SW
GPMVL
GH
N
HP
A
I
R
N
AV
I
E
A
A
ERGLS
F
GA----PT
E
ME
V
K
M
A
Q
L
V
TELV
P
TM--DM
V
RMVN
SG
T
EA
T
M
S
A
I
R
LAR
GFTG-----
-
R
DKI
I
K
F
E
G
C
YHG
H
A
DCLLVKAG
SG
A
LT
L
GQPNSP
-
-----
-
GV
P
A
D
FAKHTLTC------TYNDLASVRAAFE-
-
QYPQEI
A
C
II
V
EPV
-
A
G
N
MN
CVPPL
P
D
F
L
PG
LR
A
LCDE
F
G
A
LLI
I
DEV
MT
G
F-
R
VA
L
AG
A
QDYYGVE
PDL
T
C
L
G
K
I
I
G
GG
-
MP
V
G
A
FG
G
R
R
D
VM
D
A
LA
P
T
G
--
PVYQ
A
G
T
LS
GNP
I
A
M
AA
G
F
A
C
L
NEVAQPGVH
E
TLDELTT
RL
A
E
G
L
LE
A
A
E
Consen1
Primary consensus
MTSilPiya
a
---
aeg
l
d
eG
yvD
gi
Gh
HP
l
aAv
-
e
q
h
e
l
l
r
l
p
v
sGseA
e
A
klAr
-
r
i
F
g
yHG
t
--------
tmsl
-
g
P
d
-
aaii
EPv
-
qG
gg
pe
l
lR
lCDe
gilli
DEv
G
Rtg
lfA
PDl
t
aK
l
GG
-
mpl
a
g
aevm
a
pg
--
g
T
GNPlA
aaa
a
l
e
rl
d
L
a
e
dvRglG
Consen2
Secondary consensus
ph
vfp
-
efi
g
n
l
l
sw
y
n
ik
a
f
a
m
e
t
t
v
m
r
l
fk
l
n
f
dcllvkag
a
v
m
-
d
ccvv
iva
mn
ka
i
m
qa
mv
i
va
ag
i
c
g
i
tft
g
t
r
ia
t
nt
ag
a
i
vvg
e
f
q
f
i
ai
vm
Consensus 1
(when a gap)
Conservative difference
Consensus 2
(when a gap)
Nonconservative diff.
Other character