fig|1040638.4.peg.460
Escherichia coli O104:H4 str. LB226692
M
KL
K
QNI
E
KEI
I
K
I
N
N
IRI
H
QYT
V
LY
TSNCTID
V
YT-KEG-SNTYLRNELI
FL
E
R
G
INI
S
VRLQK
-
KKSTVN
P
FIAIRL
S
SDT
L
RR
L
KD
A
L--MIIYG
-
ISKVDACSCPNWSK
G
--
I
IVADA
DD
SVLDT
F
KS
I
DH
--
NDDS--RITSDLIY
L
I
S
KIENNRK
I
IES
I
YI
SA
VSF
F
S
DKV
RNT
IE
K
D
LS
K
R
W
T
L
AI
IA
DEFN
V
SE
IT
IRKRLE
S
E
YIT
F
NQ
IL
M
Q
S
RM
SK
A
AL
LL
LDNSYQ
I
SQ
IS
NM
I
G
FS
S
T
SYFI
RL
F
VK
H
FG
I
TPKQ
FLT
Y
F
KSQ
fig|585055.8.peg.5145
Escherichia coli 55989
M
KL
K
QNI
E
KEI
I
K
I
N
N
IRI
H
QYT
V
LY
TSNCTID
V
YT-KEG-SNTYLRNELI
FL
E
R
G
INI
S
VRLQK
-
KKSTVN
P
FIAIRL
S
SDT
L
RR
L
KD
A
L--MIIYG
-
ISKVDACSCPNWSK
G
--
I
IVADA
DD
SVLDT
F
KS
I
DH
--
NDDS--RITSDLIY
L
I
S
KIENNRK
I
IES
I
YI
SA
VSF
F
S
DKV
RNT
IE
K
D
LS
K
R
W
T
L
AI
IA
DEFN
V
SE
IT
IRKRLE
S
E
YIT
F
NQ
IL
M
Q
S
RM
SK
A
AL
LL
LDNSYQ
I
SQ
IS
NM
I
G
FS
S
T
SYFI
RL
F
VK
H
FG
I
TPKQ
FLT
Y
F
KSQ
fig|585397.6.peg.84
Escherichia coli ED1a
M
KL
K
QNI
E
KEI
I
K
I
N
N
IRI
H
QYT
V
LY
TSNCTID
V
YT-KEG-SNTYLRNELI
FL
E
R
G
INI
S
VRLQK
-
KKSTVN
P
FIAIRL
S
SDT
L
RR
L
KD
A
L--MIIYG
-
ISKVDACSCPNWSK
G
--
I
IVADA
DD
SVLDT
F
KS
I
DH
--
NDDS--RITSDLIY
L
I
S
KIENNRK
I
IES
I
YI
SA
VSF
F
S
DKV
RNT
IE
K
D
LS
K
R
W
T
L
AI
IA
DEFN
V
SE
IT
IRKRLE
S
E
YIT
F
NQ
IL
M
Q
S
RM
SK
A
AL
LL
LDNSYQ
I
SQ
IS
NM
I
G
FS
S
T
SYFI
RL
F
VK
H
FG
I
TPKQ
FLT
Y
F
KSQ
fig|216592.1.peg.5194
Escherichia coli 042
M
KL
K
QNI
E
KEI
I
K
I
N
N
IRI
H
QYT
V
LY
TSNCTID
V
YT-KEG-SNTYLRNELI
FL
E
R
G
INI
S
VRLQK
-
KKSTAN
P
FIAIRL
S
SDT
L
RR
L
KD
A
L--MIIYG
-
ISKVDACSCPNWSK
G
--
I
IVADA
DD
SVLDT
F
KS
I
DN
--
NDDS--RITSDLIY
L
I
S
KIENNKK
I
IES
I
YI
SA
VSF
F
S
DKV
RNI
IE
K
D
LS
K
R
W
T
L
AI
IA
DEFN
V
SE
IT
IRKRLE
S
E
YIT
F
NQ
IL
M
Q
S
RM
SK
A
AL
LL
LDNSYQ
I
SQ
IS
NM
I
G
FS
S
T
SYFI
RL
F
VK
H
FG
I
TPKQ
FLT
Y
F
KSQ
fig|216592.3.peg.5145
Escherichia coli 042
M
KL
K
QNI
E
KEI
I
K
I
N
N
IRI
H
QYT
V
LY
TSNCTID
V
YT-KEG-SNTYLRNELI
FL
E
R
G
INI
S
VRLQK
-
KKSTAN
P
FIAIRL
S
SDT
L
RR
L
KD
A
L--MIIYG
-
ISKVDACSCPNWSK
G
--
I
IVADA
DD
SVLDT
F
KS
I
DN
--
NDDS--RITSDLIY
L
I
S
KIENNKK
I
IES
I
YI
SA
VSF
F
S
DKV
RNI
IE
K
D
LS
K
R
W
T
L
AI
IA
DEFN
V
SE
IT
IRKRLE
S
E
YIT
F
NQ
IL
M
Q
S
RM
SK
A
AL
LL
LDNSYQ
I
SQ
IS
NM
I
G
FS
S
T
SYFI
RL
F
VK
H
FG
I
TPKQ
FLT
Y
F
KSQ
fig|331111.12.peg.79
Escherichia coli E24377A (1-263/265)
M
DF
K
YTE
E
KET
I
K
I
N
N
IMI
H
KYT
V
LY
TSNCIMD
I
YS-EEE-KITCFSNRLV
FL
E
R
G
VNI
S
VRMQK
-
QILSEK
P
YVAFRL
N
GDM
L
RH
L
KD
A
L--MIIYG
-
MSKIDTNACRSMSR
K
--
I
MTTEV
N
K
TLLDE
L
KN
I
NS
--
HDNS--AFISSLIY
L
I
S
KLENNEK
I
IES
I
YI
S
S
VSF
F
S
DKV
RNL
IE
K
D
LS
R
K
W
T
L
GI
IA
DAFN
A
SE
IT
IRKRLE
S
E
NTN
F
NQ
IL
M
Q
L
RM
SK
A
AL
LL
LENSYQ
I
SQ
IS
NM
I
G
IS
S
A
SYFI
RI
F
NK
H
Y
G
V
TPKQ
FFT
Y
F
K
fig|358709.5.peg.2502
Escherichia coli 101-1 (5-261/262)
HL
E
SDQ
I
K
I
N
N
VRV
H
KYT
ILY
TSNCIMD
I
DI-SGK-TFFCDSNKFV
FL
E
R
G
VNL
S
VRIKK
-
IDIAKK
P
YFVIRL
H
EDI
L
FC
L
KN
V
M--VNIYG
-
LS--PEAHERTSES
K
--
V
LICDE
DK
SSREL
F
EE
I
QK
--
KDFSL-NIVPELLY
F
I
S
KQQSRRK
I
VES
I
YI
S
S
VTF
F
S
DK
I
RSA
IE
K
D
LS
K
K
W
K
L
NI
IA
DQFN
V
SE
IT
IRKRLE
I
E
NIS
F
NQ
ILL
Q
A
RM
TR
A
AI
L
I
LENSYQ
I
AQ
IS
NM
VG
IS
S
T
SYFI
RL
F
NK
H
FG
V
TPKQ
FVS
Y
F
R
fig|362663.8.peg.3857
Escherichia coli 536 (18-271/271)
I
S
I
R
N
IAT
N
KFL
I
I
H
TDNCDLH
I
EN-EHG-NFFCTRGSFV
F
M
S
RN
MNF
S
CRIHK
-
IETGRP
P
YKTIRL
G
REE
L
TM
L
TN
I
LHSTHVYC
-
LN--KHITEGKSHN
G
--
I
VCIGG
N
K
DWGYI
F
NK
I
ET
--
SKDSA-LKMLKLSY
L
I
S
RMGIAPD
I
IIS
L
MA
S
T
AVT
F
T
E
K
I
RNQ
IE
N
N
PS
K
R
W
C
L
NM
IA
DEFN
I
SE
IS
V
RKRLE
S
E
GTS
F
SN
L
F
L
K
V
RM
EK
S
MQ
LL
LQNELQ
I
CQ
IS
KS
VG
FR
S
T
SYFI
KI
F
KD
YFG
I
TPKQ
LII
Y
F
RN
fig|362663.9.peg.3871
Escherichia coli 536 (18-271/271)
I
S
I
R
N
IAT
N
KFL
I
I
H
TDNCDLH
I
EN-EHG-NFFCTRGSFV
F
M
S
RN
MNF
S
CRIHK
-
IETGRP
P
YKTIRL
G
REE
L
TM
L
TN
I
LHSTHVYC
-
LN--KHITEGKSHN
G
--
I
VCIGG
N
K
DWGYI
F
NK
I
ET
--
SKDSA-LKMLKLSY
L
I
S
RMGIAPD
I
IIS
L
MA
S
T
AVT
F
T
E
K
I
RNQ
IE
N
N
PS
K
R
W
C
L
NM
IA
DEFN
I
SE
IS
V
RKRLE
S
E
GTS
F
SN
L
F
L
K
V
RM
EK
S
MQ
LL
LQNELQ
I
CQ
IS
KS
VG
FR
S
T
SYFI
KI
F
KD
YFG
I
TPKQ
LII
Y
F
RN
fig|344610.7.peg.284
Escherichia coli 53638 (21-267/269)
VRL
H
NYI
ILY
AKRCSMT
V
SS-GNE-TLTIDEGQIA
F
I
E
RN
IQI
N
VSIKK
-
-SDSIN
P
FEIISL
D
RNL
L
LS
I
IR
I
M--EPIYS
-
FQHSYSEEKRGLNK
K
--
I
FLLSE
E
E
VSIDL
F
KS
I
KE
--
MPFGK-RKIYSLAC
L
L
S
AVSDEEA
L
YTS
I
SI
A
S
SLS
F
S
D
Q
I
RKI
V
E
K
N
IE
K
R
W
R
L
SD
I
S
NNLN
L
SE
IA
V
RKRLE
S
E
KLT
F
QQ
ILLD
I
RM
HH
A
AK
LL
LNSQSY
I
ND
V
S
RL
I
G
IS
S
P
SYFI
RK
F
NE
Y
Y
G
I
TPK
K
FYL
Y
H
K
fig|344610.3.peg.5142
Escherichia coli 53638 (14-260/262)
VRL
H
NYI
ILY
AKRCSMT
V
SS-GNE-TLTIDEGQIA
F
I
E
RN
IQI
N
VSIKK
-
-SDSIN
P
FEIISL
D
RNL
L
LS
I
IR
I
M--EPIYS
-
FQHSYSEEKRGLNK
K
--
I
FLLSE
E
E
VSIDL
F
KS
I
KE
--
MPFGK-RKIYSLAC
L
L
S
AVSDEEA
L
YTS
I
SI
A
S
SLS
F
S
D
Q
I
RKI
V
E
K
N
IE
K
R
W
R
L
SD
I
S
NNLN
L
SE
IA
V
RKRLE
S
E
KLT
F
QQ
ILLD
I
RM
HH
A
AK
LL
LNSQSY
I
ND
V
S
RL
I
G
IS
S
P
SYFI
RK
F
NE
Y
Y
G
I
TPK
K
FYL
Y
H
K
fig|749546.3.peg.1809
Escherichia coli MS 185-1 (13-262/263)
VRL
Y
EYT
I
V
Y
TNKCTLH
V
TY-GNE-HLTIKEGCIA
F
F
E
K
H
IEI
N
ISIIK
R
TNTETN
P
FEVISI
N
NDL
L
SK
V
LT
I
M--DPIYS
-
FSFGQMQRKRRLQQ
R
--
I
FMIDG
D
I
ISTEI
F
KS
I
KS
--
MKVCN-EKVYKLAC
L
F
S
IVDNECD
F
FSS
I
CV
S
T
SIS
F
T
DKV
KKI
IE
C
D
FE
K
K
W
K
L
SD
I
S
EEMN
MSE
VA
V
RK
N
LE
N
E
NIT
F
QQ
V
LLD
S
K
M
NY
A
AK
L
I
LNSKNH
I
NN
V
S
KL
I
G
MS
S
T
SYFI
KL
F
NS
Y
Y
G
V
TPK
K
FYF
Y
H
KS
fig|550672.3.peg.4214
Escherichia coli B088 (32-284/285)
V
L
V
L
K
K
IRF
Y
NCA
I
I
Y
LHDAQLL
V
KT-KDGQSFNVPPESLC
YV
E
K
N
TVI
D
VALKV
-
-LGQGV
P
YEIYHI
D
SDV
L
SC
I
CK
V
M--EPLLL
-
----EPQNVSQMRR
K
--
I
FTCSV
D
E
TDIKI
F
KR
L
IG
--
NDVPQHRQVYKITY
L
L
S
KIRDIES
L
VYS
L
SV
S
T
DTT
F
T
ERL
KTI
IE
A
D
LA
K
S
W
K
L
AD
L
A
SILH
MSE
VS
IRK
K
LE
K
E
SNN
F
NT
L
V
LD
I
RM
HQ
A
AK
L
I
TTTEKH
I
NS
I
A
NE
VG
YT
S
T
SYFI
RN
F
KE
F
FG
I
TPKQ
FSL
K
V
K
K
Q
fig|656440.3.peg.4306
Escherichia coli TA206 (6-257/258)
IRT
N
KFT
M
F
Y
TADNDVV
V
TNISDNTQTYCGKNSVV
I
V
G
RN
VRV
S
FITKE
-
-FHGDI
L
KRAVFF
D
YSQ
I
VK
L
KK
I
LYLTCFFS
N
TAQHDFASSLPEVK
K
--
V
ICIEA
N
N
IMKES
F
EE
M
IK
--
ANSEH-DRAISFML
F
C
K
RSGIEQS
I
FNL
I
LL
SA
VNT
F
C
S
KV
IDL
IE
S
D
IS
K
K
W
T
L
RI
L
A
DEFN
L
SE
VA
IRK
K
LE
S
E
GIC
F
RD
L
I
L
E
T
RM
KK
A
MS
LL
IEGGMS
V
SK
IS
TS
I
G
YH
N
T
SYFI
SY
F
RS
F
FG
I
TPKQ
LQA
L
L
K
fig|362663.8.peg.3837
Escherichia coli 536 (38-284/290)
LRT
N
KLA
ILY
TGEHDIL
V
TNLSDNTQIRCKRNSVV
I
V
G
RN
VRI
S
FMADQ
-
-LYDRI
L
RDTVFF
D
HTQ
I
IT
L
KK
I
LSLAYGFS
K
INPLDFETDSPKIR
K
--
I
ISIEV
N
D
RIKNS
F
YN
I
IS
--
EDSHH-NRILSFIF
F
C
K
ESSVMDA
I
LPL
I
YF
SA
ATT
F
C
NR
V
IEL
IE
S
N
IA
K
K
W
T
L
RL
L
S
EEFS
I
SE
IA
IRK
K
LE
A
E
GVI
F
RE
L
I
L
E
I
RM
KK
A
MT
LL
IAGELS
V
SK
I
A
DK
VG
YN
N
I
SYFI
SH
F
RQ
F
FG
M
TPKQ
L
fig|362663.9.peg.3851
Escherichia coli 536 (38-284/290)
LRT
N
KLA
ILY
TGEHDIL
V
TNLSDNTQIRCKRNSVV
I
V
G
RN
VRI
S
FMADQ
-
-LYDRI
L
RDTVFF
D
HTQ
I
IT
L
KK
I
LSLAYGFS
K
INPLDFETDSPKIR
K
--
I
ISIEV
N
D
RIKNS
F
YN
I
IS
--
EDSHH-NRILSFIF
F
C
K
ESSVMDA
I
LPL
I
YF
SA
ATT
F
C
NR
V
IEL
IE
S
N
IA
K
K
W
T
L
RL
L
S
EEFS
I
SE
IA
IRK
K
LE
A
E
GVI
F
RE
L
I
L
E
I
RM
KK
A
MT
LL
IAGELS
V
SK
I
A
DK
VG
YN
N
I
SYFI
SH
F
RQ
F
FG
M
TPKQ
L
fig|753642.3.peg.141
Escherichia coli NC101 (9-275/278)
KL
NL
S
DK
R
AIL
N
INR
L
E
I
R
D
VHF
F
ECT
I
I
Y
LYDARIV
L
KN-SNGKKTIIFPQSIC
YI
E
K
N
TTV
D
IIICD
-
-KKKGR
P
YDVYNV
D
GDI
L
NN
I
CE
I
M--SPLLS
-
----HFGNVNYPYA
K
--
V
FSFTA
DD
VDKKI
F
HL
L
MK
--
KETPYYRKLYKLTY
L
L
S
KCDNIET
L
IYS
L
SK
S
K
NKT
I
T
ERL
KDI
IE
S
D
LS
K
T
W
Q
I
SD
F
A
KILH
MSE
SL
IRKRL
K
G
E
NIN
Y
NT
L
IV
D
I
RM
NY
A
FN
M
L
MATEKN
I
NI
IS
RE
VG
YV
S
T
SYFI
SK
F
RN
YFG
I
TPKQ
FSI
K
V
K
N
K
fig|344601.3.peg.3960
Escherichia coli B171 (8-262/274)
MQ
S
SE
N
KQE
E
NLA
L
L
L
T
N
YIS
Y
QNI
VIF
TGGNQFK
I
RNKKEFTEYTIESNSLF
FL
A
K
N
THW
D
MEIVG
-
-IDNSN
P
YRKIII
D
DAL
I
KL
L
HS
I
SSDDSCYV
-
------------KK
K
--
I
FTANL
NE
MQLNI
V
SN
I
IT
DI
KYSGNNKKTFKILY
L
L
S
FFDDYND
I
VNV
I
LS
A
S
SKS
I
V
D
R
V
IKV
IE
L
D
IS
K
N
W
K
L
GD
V
S
SSMF
MS
D
SC
L
RK
Q
L
N
K
E
NLT
F
KK
I
M
LD
I
K
M
KH
A
SL
F
L
RTTDKN
I
DE
IS
CL
VG
FN
S
T
SYFI
KV
F
KE
Y
YN
T
TPK
K
Y
fig|344601.5.peg.4158
Escherichia coli B171 (8-262/274)
MQ
S
SE
N
KQE
E
NLA
L
L
L
T
N
YIS
Y
QNI
VIF
TGGNQFK
I
RNKKEFTEYTIESNSLF
FL
A
K
N
THW
D
MEIVG
-
-IDNSN
P
YRKIII
D
DAL
I
KL
L
HS
I
SSDDSCYV
-
------------KK
K
--
I
FTANL
NE
MQLNI
V
SN
I
IT
DI
KYSGNNKKTFKILY
L
L
S
FFDDYND
I
VNV
I
LS
A
S
SKS
I
V
D
R
V
IKV
IE
L
D
IS
K
N
W
K
L
GD
V
S
SSMF
MS
D
SC
L
RK
Q
L
N
K
E
NLT
F
KK
I
M
LD
I
K
M
KH
A
SL
F
L
RTTDKN
I
DE
IS
CL
VG
FN
S
T
SYFI
KV
F
KE
Y
YN
T
TPK
K
Y
fig|216593.1.peg.1113
Escherichia coli E2348/69 (8-262/274)
MQ
S
SE
N
KQE
E
NLA
L
L
L
T
N
YIS
Y
QNI
VIF
TGGNQFK
I
RNKKEFTEYTIESNSLF
FL
A
K
N
THW
D
MEIVG
-
-IDNSN
P
YRKIII
D
DAL
I
KL
L
HS
I
SSDDSCYV
-
------------KK
K
--
I
FTANL
NE
MQLNI
V
SN
I
IT
DI
KYSGNNKKIFKILY
L
L
S
FFNDYND
I
VNV
I
LS
A
S
SKS
I
V
D
R
V
IKV
IE
L
D
IS
K
N
W
K
L
GD
V
S
SSMF
MS
D
SC
L
RK
Q
L
N
K
E
NLT
F
KK
I
M
LD
I
K
M
KH
A
SL
F
L
RTTDKN
I
DE
IS
CL
VG
FN
S
T
SYFI
KV
F
KE
Y
YN
T
TPK
K
Y
fig|574521.7.peg.4831
Escherichia coli O127:H6 str. E2348/69 (8-262/274)
MQ
S
SE
N
KQE
E
NLA
L
L
L
T
N
YIS
Y
QNI
VIF
TGGNQFK
I
RNKKEFTEYTIESNSLF
FL
A
K
N
THW
D
MEIVG
-
-IDNSN
P
YRKIII
D
DAL
I
KL
L
HS
I
SSDDSCYV
-
------------KK
K
--
I
FTANL
NE
MQLNI
V
SN
I
IT
DI
KYSGNNKKIFKILY
L
L
S
FFNDYND
I
VNV
I
LS
A
S
SKS
I
V
D
R
V
IKV
IE
L
D
IS
K
N
W
K
L
GD
V
S
SSMF
MS
D
SC
L
RK
Q
L
N
K
E
NLT
F
KK
I
M
LD
I
K
M
KH
A
SL
F
L
RTTDKN
I
DE
IS
CL
VG
FN
S
T
SYFI
KV
F
KE
Y
YN
T
TPK
K
Y
fig|550672.3.peg.642
Escherichia coli B088 (25-270/281)
I
N
N
IRL
R
SSI
L
LY
IKQSGIV
L
KI-NNGKDIIPHKDSVF
F
I
D
KG
AVV
T
LQTKK
-
----SE
S
YDIYYF
S
ISE
I
KR
A
FN
I
LCTLIFNA
-
SDHAERTNNNQDDY
K
GDY
LYVKL
A
E
GDYFI
F
KR
L
HA
--
-DISVLRKTHVLLY
F
L
S
G-QTTSL
L
FYF
F
KK
N
I
EFS
F
S
E
S
V
KLI
IE
E
D
LS
A
S
W
K
I
SD
I
C
NIMY
I
SE
SS
A
RK
K
L
L
Q
E
NKT
F
CG
ILL
E
A
RM
QA
A
AK
M
I
LTTEKH
I
NA
V
S
KR
VG
YS
S
P
SYFI
KS
F
KN
F
F
K
I
TPKQ
L
Consen1
Primary consensus
MQm
k
E
i
i
n
h
ily
v
fl
rn
s
-
p
d
l
l
i
-
k
--
i
ne
f
i
--
l
s
i
i
sa
f
dkv
IE
d
K
W
L
ia
mSe
iRKrLe
E
F
illd
rM
A
ll
i
is
vG
s
SYFI
F
yfg
TPKq
y
ksQ
Consen2
Secondary consensus
s
n
l
l
vif
i
i
kg
l
i
i
a
k
g
v
v
l
di
f
k
l
l
a
i
i
n
s
d
n
l
m
k
fi
v
va
i
n
yn
k
k
rn
Consensus 1
(when a gap)
Conservative difference
Consensus 2
(when a gap)
Nonconservative diff.
Other character