fig|1040638.4.peg.4427
Escherichia coli O104:H4 str. LB226692
M
L
ST
Q
F
NRDNQ
Y
QA
IT
KPS
L
LAGCI
A
LAL
L
P
S
A
A
F
A
A
P
ATE
ETVIV
EG
SA
T
---
AP
D
D
GEN
DY
S
V
T
ST
------
SAGTKMQM
T
QR
DIPQSVT
I
VS
Q
Q
R
ME
D
QQ
LQ
TL
G
EV
M
E
NT
L
G
I
---
-
-
S
K
S
Q
A
D
S
D
R
A
LYY
SRGF
------
QI
DNYM
--
V
DGI
P
T
YFESR
WNLGDA
LS
DM
-
AL
F
ERVEVVRG
A
T
G
L
M
T
G
TG
NP
SA
AINMV
R
K
H
AT
SRE
------------
FKGDVSAEYGS
W
NK
ER
Y
VA
D
L
Q
SP
L
TE
DG
KIR
ARIVG
GY
QN
N
D
S
W
LDRYN
SE
K
TF
------
FSG
IV
D
A
DL
G
DL
T
T
LSAG
YEY
Q
RIDVNS
P
T
WGG
----
LP
RW
N
T
D
-----
GS
S
N
SYDR
AR
ST
AP
D
WAY
ND
K
EI
N
--------
K
V
FM
TLK
Q
R
FADTWQAT
L
N
AT
HSE
V
EFD
SKMMY
V
D
AY
VNKADGMLVGPYSNYGPGF
DY
V
G
GTG
WN
S
G
---------------------------
-
-
K
R
K
VDA
-------
--
-
--
-
-
---
-
L
D
LF
A
DG
IY
EL
FGR
QH
N
LMFGG
----------
SYSK
QN
N
RYFSSWANIFPD
EI
GSF
Y
N
FN
GN
F
P
QT
D
-
-
--
W
SP
-------------
----
---
------------QS
L
A
QDD
T
TH
M
KS
L
YAA
T
RVT
L
A
D
PLHLI
LG
A
R
-------
Y
----
--
-TNW
R
--------------
VDTLTY
-----
SM
EK
N
HT
----
TP
YA
GLVF
D
I
N
DNWS
T
YASYT
S
I
FQP
---------
Q
N
-
DR
D
SS
G
KY
-
L
A
P
I
TGNNYE
-------
LGLK
SDWM
N
SR
LT
T
T
L
AIF
R
I
E
Q
D
NVA
Q
S
---
T
GT
P
I
PGSN
GE
T
AYKAVDGTV
SKGVE
F
ELN
---
GA
I
T
D
NWQL
TF
GA
T
R
Y
I
AE
DN
-------
E
G
N
A
VN
PNLP
-----
RTTVKMF
T
SY
R
L
P
VMP
E
---
LT
V
G
-----
GGV
N
W
QN
--
R
VY
TDT
VT
PY
G
-
TFR
A
EQ
GSYALVDLFTRY
Q
VTK
----
NF
SLQGNVNNLFDKTY
D
TN
VE
GSIVY
-
--
-
G
T
PR
N
F
SI
TGTYQF
fig|6666666.5357.peg.1304
Escherichia coli TY-2482
M
L
ST
Q
F
NRDNQ
Y
QA
IT
KPS
L
LAGCI
A
LAL
L
P
S
A
A
F
A
A
P
ATE
ETVIV
EG
SA
T
---
AP
D
D
GEN
DY
S
V
T
ST
------
SAGTKMQM
T
QR
DIPQSVT
I
VS
Q
Q
R
ME
D
QQ
LQ
TL
G
EV
M
E
NT
L
G
I
---
-
-
S
K
S
Q
A
D
S
D
R
A
LYY
SRGF
------
QI
DNYM
--
V
DGI
P
T
YFESR
WNLGDA
LS
DM
-
AL
F
ERVEVVRG
A
T
G
L
M
T
G
TG
NP
SA
AINMV
R
K
H
AT
SRE
------------
FKGDVSAEYGS
W
NK
ER
Y
VA
D
L
Q
SP
L
TE
DG
KIR
ARIVG
GY
QN
N
D
S
W
LDRYN
SE
K
TF
------
FSG
IV
D
A
DL
G
DL
T
T
LSAG
YEY
Q
RIDVNS
P
T
WGG
----
LP
RW
N
T
D
-----
GS
S
N
SYDR
AR
ST
AP
D
WAY
ND
K
EI
N
--------
K
V
FM
TLK
Q
R
FADTWQAT
L
N
AT
HSE
V
EFD
SKMMY
V
D
AY
VNKADGMLVGPYSNYGPGF
DY
V
G
GTG
WN
S
G
---------------------------
-
-
K
R
K
VDA
-------
--
-
--
-
-
---
-
L
D
LF
A
DG
IY
EL
FGR
QH
N
LMFGG
----------
SYSK
QN
N
RYFSSWANIFPD
EI
GSF
Y
N
FN
GN
F
P
QT
D
-
-
--
W
SP
-------------
----
---
------------QS
L
A
QDD
T
TH
M
KS
L
YAA
T
RVT
L
A
D
PLHLI
LG
A
R
-------
Y
----
--
-TNW
R
--------------
VDTLTY
-----
SM
EK
N
HT
----
TP
YA
GLVF
D
I
N
DNWS
T
YASYT
S
I
FQP
---------
Q
N
-
DR
D
SS
G
KY
-
L
A
P
I
TGNNYE
-------
LGLK
SDWM
N
SR
LT
T
T
L
AIF
R
I
E
Q
D
NVA
Q
S
---
T
GT
P
I
PGSN
GE
T
AYKAVDGTV
SKGVE
F
ELN
---
GA
I
T
D
NWQL
TF
GA
T
R
Y
I
AE
DN
-------
E
G
N
A
VN
PNLP
-----
RTTVKMF
T
SY
R
L
P
VMP
E
---
LT
V
G
-----
GGV
N
W
QN
--
R
VY
TDT
VT
PY
G
-
TFR
A
EQ
GSYALVDLFTRY
Q
VTK
----
NF
SLQGNVNNLFDKTY
D
TN
VE
GSIVY
-
--
-
G
T
PR
N
F
SI
TGTYQF
fig|585055.6.peg.1245
Escherichia coli 55989
M
L
ST
Q
F
NRDNQ
Y
QA
IT
KPS
L
LAGCI
A
LAL
L
P
S
A
A
F
A
A
P
ATE
ETVIV
EG
SA
T
---
AP
D
D
GEN
DY
S
V
T
ST
------
SAGTKMQM
T
QR
DIPQSVT
I
VS
Q
Q
R
ME
D
QQ
LQ
TL
G
EV
M
E
NT
L
G
I
---
-
-
S
K
S
Q
A
D
S
D
R
A
LYY
SRGF
------
QI
DNYM
--
V
DGI
P
T
YFESR
WNLGDA
LS
DM
-
AL
F
ERVEVVRG
A
T
G
L
M
T
G
TG
NP
SA
AINMV
R
K
H
AT
SRE
------------
FKGDVSAEYGS
W
NK
ER
Y
VA
D
L
Q
SP
L
TE
DG
KIR
ARIVG
GY
QN
N
D
S
W
LDRYN
SE
K
TF
------
FSG
IV
D
A
DL
G
DL
T
T
LSAG
YEY
Q
RIDVNS
P
T
WGG
----
LP
RW
N
T
D
-----
GS
S
N
SYDR
AR
ST
AP
D
WAY
ND
K
EI
N
--------
K
V
FM
TLK
Q
R
FADTWQAT
L
N
AT
HSE
V
EFD
SKMMY
V
D
AY
VNKADGMLVGPYSNYGPGF
DY
V
G
GTG
WN
S
G
---------------------------
-
-
K
R
K
VDA
-------
--
-
--
-
-
---
-
L
D
LF
A
DG
IY
EL
FGR
QH
N
LMFGG
----------
SYSK
QN
N
RYFSSWANIFPD
EI
GSF
Y
N
FN
GN
F
P
QT
D
-
-
--
W
SP
-------------
----
---
------------QS
L
A
QDD
T
TH
M
KS
L
YAA
T
RVT
L
A
D
PLHLI
LG
A
R
-------
Y
----
--
-TNW
R
--------------
VDTLTY
-----
SM
EK
N
HT
----
TP
YA
GLVF
D
I
N
DNWS
T
YASYT
S
I
FQP
---------
Q
N
-
DR
D
SS
G
KY
-
L
A
P
I
TGNNYE
-------
LGLK
SDWM
N
SR
LT
T
T
L
AIF
R
I
E
Q
D
NVA
Q
S
---
T
GT
P
I
PGSN
GE
T
AYKAVDGTV
SKGVE
F
ELN
---
GA
I
T
D
NWQL
TF
GA
T
R
Y
I
AE
DN
-------
E
G
N
A
VN
PNLP
-----
RTTVKMF
T
SY
R
L
P
VMP
E
---
LT
V
G
-----
GGV
N
W
QN
--
R
VY
TDT
VT
PY
G
-
TFR
A
EQ
GSYALVDLFTRY
Q
VTK
----
NF
SLQGNVNNLFDKTY
D
TN
VE
GSIVY
-
--
-
G
T
PR
N
F
SI
TGTYQF
fig|585055.8.peg.1244
Escherichia coli 55989
M
L
ST
Q
F
NRDNQ
Y
QA
IT
KPS
L
LAGCI
A
LAL
L
P
S
A
A
F
A
A
P
ATE
ETVIV
EG
SA
T
---
AP
D
D
GEN
DY
S
V
T
ST
------
SAGTKMQM
T
QR
DIPQSVT
I
VS
Q
Q
R
ME
D
QQ
LQ
TL
G
EV
M
E
NT
L
G
I
---
-
-
S
K
S
Q
A
D
S
D
R
A
LYY
SRGF
------
QI
DNYM
--
V
DGI
P
T
YFESR
WNLGDA
LS
DM
-
AL
F
ERVEVVRG
A
T
G
L
M
T
G
TG
NP
SA
AINMV
R
K
H
AT
SRE
------------
FKGDVSAEYGS
W
NK
ER
Y
VA
D
L
Q
SP
L
TE
DG
KIR
ARIVG
GY
QN
N
D
S
W
LDRYN
SE
K
TF
------
FSG
IV
D
A
DL
G
DL
T
T
LSAG
YEY
Q
RIDVNS
P
T
WGG
----
LP
RW
N
T
D
-----
GS
S
N
SYDR
AR
ST
AP
D
WAY
ND
K
EI
N
--------
K
V
FM
TLK
Q
R
FADTWQAT
L
N
AT
HSE
V
EFD
SKMMY
V
D
AY
VNKADGMLVGPYSNYGPGF
DY
V
G
GTG
WN
S
G
---------------------------
-
-
K
R
K
VDA
-------
--
-
--
-
-
---
-
L
D
LF
A
DG
IY
EL
FGR
QH
N
LMFGG
----------
SYSK
QN
N
RYFSSWANIFPD
EI
GSF
Y
N
FN
GN
F
P
QT
D
-
-
--
W
SP
-------------
----
---
------------QS
L
A
QDD
T
TH
M
KS
L
YAA
T
RVT
L
A
D
PLHLI
LG
A
R
-------
Y
----
--
-TNW
R
--------------
VDTLTY
-----
SM
EK
N
HT
----
TP
YA
GLVF
D
I
N
DNWS
T
YASYT
S
I
FQP
---------
Q
N
-
DR
D
SS
G
KY
-
L
A
P
I
TGNNYE
-------
LGLK
SDWM
N
SR
LT
T
T
L
AIF
R
I
E
Q
D
NVA
Q
S
---
T
GT
P
I
PGSN
GE
T
AYKAVDGTV
SKGVE
F
ELN
---
GA
I
T
D
NWQL
TF
GA
T
R
Y
I
AE
DN
-------
E
G
N
A
VN
PNLP
-----
RTTVKMF
T
SY
R
L
P
VMP
E
---
LT
V
G
-----
GGV
N
W
QN
--
R
VY
TDT
VT
PY
G
-
TFR
A
EQ
GSYALVDLFTRY
Q
VTK
----
NF
SLQGNVNNLFDKTY
D
TN
VE
GSIVY
-
--
-
G
T
PR
N
F
SI
TGTYQF
fig|358709.5.peg.4466
Escherichia coli 101-1
M
L
ST
Q
F
NRDNQ
Y
QA
IT
KPS
L
LAGCI
A
LAL
L
P
S
A
A
F
A
A
P
ATE
ETVIV
EG
SA
T
---
AP
D
D
GEN
DY
S
V
T
ST
------
SAGTKMQM
T
QR
DIPQSVT
I
VS
Q
Q
R
ME
D
QQ
LQ
TL
G
EV
M
E
NT
L
G
I
---
-
-
S
K
S
Q
A
D
S
D
R
A
LYY
SRGF
------
QI
DNYM
--
V
DGI
P
T
YFESR
WNLGDA
LS
DM
-
AL
F
ERVEVVRG
A
T
G
L
M
T
G
TG
NP
SA
AINMV
R
K
H
AT
SRE
------------
FKGDVSAEYGS
W
NK
ER
Y
VA
D
L
Q
SP
L
TE
DG
KIR
ARIVG
GY
QN
N
D
S
W
LDRYN
SE
K
TF
------
FSG
IV
D
A
DL
G
DL
T
T
LSAG
YEY
Q
RIDVNS
P
T
WGG
----
LP
RW
N
T
D
-----
GS
S
N
SYDR
AR
ST
AP
D
WAY
ND
K
EI
N
--------
K
V
FM
TLK
Q
R
FADTWQAT
L
N
AT
HSE
V
EFD
SKMMY
V
D
AY
VNKADGMLVGPYSNYGPGF
DY
V
G
GTG
WN
S
G
---------------------------
-
-
K
R
K
VDA
-------
--
-
--
-
-
---
-
L
D
LF
A
DG
IY
EL
FGR
QH
N
LMFGG
----------
SYSK
QN
N
RYFSSWANIFPD
EI
GSF
Y
N
FN
GN
F
P
QT
D
-
-
--
W
SP
-------------
----
---
------------QS
L
A
QDD
T
TH
M
KS
L
YAA
T
RVT
L
A
D
PLHLI
LG
A
R
-------
Y
----
--
-TNW
R
--------------
VDTLTY
-----
SM
EK
N
HT
----
TP
YA
GLVF
D
I
N
DNWS
T
YASYT
S
I
FQP
---------
Q
N
-
DR
D
SS
G
KY
-
L
A
P
I
TGNNYE
-------
LGLK
SDWM
N
SR
LT
T
T
L
AIF
R
I
E
Q
D
NVA
Q
S
---
T
GT
P
I
PGSN
GE
T
AYKAVDGTV
SKGVE
F
ELN
---
GA
I
T
D
NWQL
TF
GA
T
R
Y
I
AE
DN
-------
E
G
N
A
VN
PNLP
-----
RTTVKMF
T
SY
R
L
P
VMP
E
---
LT
V
G
-----
GGV
N
W
QN
--
R
VY
TDT
VT
PY
G
-
TFR
A
EQ
GSYALVDLFTRY
Q
VTK
----
NF
SLQGNVNNLFDKTY
D
TN
VE
GSIVY
-
--
-
GAPR
N
F
SI
TGTYQF
fig|344610.3.peg.4616
Escherichia coli 53638
M
L
ST
Q
F
NRDNQ
Y
QA
IT
KPS
L
LAGCI
A
LAL
L
P
S
A
A
F
A
A
P
ATE
ETVIV
EG
SA
T
---
AP
D
D
GEN
DY
S
V
T
ST
------
SAGTKMQM
T
QR
DIPQSVT
I
VS
Q
Q
R
ME
D
QQ
LQ
TL
G
EV
M
E
NT
L
G
I
---
-
-
S
K
S
Q
A
D
S
D
R
A
LYY
SRGF
------
QI
DNYM
--
V
DGI
P
T
YFESR
WNLGDA
LS
DM
-
AL
F
ERVEVVRG
A
T
G
L
M
T
G
TG
NP
SA
AINMV
R
K
H
AT
SRE
------------
FKGDVSAEYGS
W
NK
ER
Y
VA
D
L
Q
SP
L
TE
DG
KIR
ARIVG
GY
QN
N
D
S
W
LDRYN
SE
K
TF
------
FSG
IV
D
A
DL
G
DL
T
T
LSAG
YEY
Q
RIDVNS
P
T
WGG
----
LP
RW
N
T
D
-----
GS
S
N
SYDR
AR
ST
AP
D
WAY
ND
K
EI
N
--------
K
V
FM
TLK
Q
R
FADTWQAT
L
N
AT
HSE
V
EFD
SKMMY
V
D
AY
VNKADGMLVGPYSNYGPGF
DY
V
G
GTG
WN
S
G
---------------------------
-
-
K
R
K
VDA
-------
--
-
--
-
-
---
-
L
D
LF
A
DG
IY
EL
FGR
QH
N
LMFGG
----------
SYSK
QN
N
RYFSSWANIFPD
EI
GSF
Y
N
FN
GN
F
P
QT
D
-
-
--
W
SP
-------------
----
---
------------QS
L
A
QDD
T
TH
M
KS
L
YAA
T
RVT
L
A
D
PLHLI
LG
A
R
-------
Y
----
--
-TNW
R
--------------
VDTLTY
-----
SM
EK
N
HT
----
TP
YA
GLVF
D
I
N
DNWS
T
YASYT
S
I
FQP
---------
Q
N
-
DR
D
SS
G
KY
-
L
A
P
I
TGNNYE
-------
LGLK
SDWM
N
SR
LT
T
T
L
AIF
R
I
E
Q
D
NVA
Q
S
---
T
GT
P
I
PGSN
GE
T
AYKAVDGTV
SKGVE
F
ELN
---
GA
I
T
D
NWQL
TF
GA
T
R
Y
I
AE
DN
-------
E
G
N
A
VN
PNLP
-----
RTTVKMF
T
SY
R
L
P
VMP
E
---
LT
V
G
-----
GGV
N
W
QN
--
R
VY
TDT
VT
PY
G
-
TFR
A
EQ
GSYALVDLFTRY
Q
VTK
----
NF
SLQGNVNNLFDKTY
D
TN
VE
GSIVY
-
--
-
GAPR
N
F
SI
TGTYQF
fig|344610.7.peg.542
Escherichia coli 53638
M
L
ST
Q
F
NRDNQ
Y
QA
IT
KPS
L
LAGCI
A
LAL
L
P
S
A
A
F
A
A
P
ATE
ETVIV
EG
SA
T
---
AP
D
D
GEN
DY
S
V
T
ST
------
SAGTKMQM
T
QR
DIPQSVT
I
VS
Q
Q
R
ME
D
QQ
LQ
TL
G
EV
M
E
NT
L
G
I
---
-
-
S
K
S
Q
A
D
S
D
R
A
LYY
SRGF
------
QI
DNYM
--
V
DGI
P
T
YFESR
WNLGDA
LS
DM
-
AL
F
ERVEVVRG
A
T
G
L
M
T
G
TG
NP
SA
AINMV
R
K
H
AT
SRE
------------
FKGDVSAEYGS
W
NK
ER
Y
VA
D
L
Q
SP
L
TE
DG
KIR
ARIVG
GY
QN
N
D
S
W
LDRYN
SE
K
TF
------
FSG
IV
D
A
DL
G
DL
T
T
LSAG
YEY
Q
RIDVNS
P
T
WGG
----
LP
RW
N
T
D
-----
GS
S
N
SYDR
AR
ST
AP
D
WAY
ND
K
EI
N
--------
K
V
FM
TLK
Q
R
FADTWQAT
L
N
AT
HSE
V
EFD
SKMMY
V
D
AY
VNKADGMLVGPYSNYGPGF
DY
V
G
GTG
WN
S
G
---------------------------
-
-
K
R
K
VDA
-------
--
-
--
-
-
---
-
L
D
LF
A
DG
IY
EL
FGR
QH
N
LMFGG
----------
SYSK
QN
N
RYFSSWANIFPD
EI
GSF
Y
N
FN
GN
F
P
QT
D
-
-
--
W
SP
-------------
----
---
------------QS
L
A
QDD
T
TH
M
KS
L
YAA
T
RVT
L
A
D
PLHLI
LG
A
R
-------
Y
----
--
-TNW
R
--------------
VDTLTY
-----
SM
EK
N
HT
----
TP
YA
GLVF
D
I
N
DNWS
T
YASYT
S
I
FQP
---------
Q
N
-
DR
D
SS
G
KY
-
L
A
P
I
TGNNYE
-------
LGLK
SDWM
N
SR
LT
T
T
L
AIF
R
I
E
Q
D
NVA
Q
S
---
T
GT
P
I
PGSN
GE
T
AYKAVDGTV
SKGVE
F
ELN
---
GA
I
T
D
NWQL
TF
GA
T
R
Y
I
AE
DN
-------
E
G
N
A
VN
PNLP
-----
RTTVKMF
T
SY
R
L
P
VMP
E
---
LT
V
G
-----
GGV
N
W
QN
--
R
VY
TDT
VT
PY
G
-
TFR
A
EQ
GSYALVDLFTRY
Q
VTK
----
NF
SLQGNVNNLFDKTY
D
TN
VE
GSIVY
-
--
-
GAPR
N
F
SI
TGTYQF
fig|481805.3.peg.2685
Escherichia coli ATCC 8739
M
L
ST
Q
F
NRDNQ
Y
QA
IT
KPS
L
LAGCI
A
LAL
L
P
S
A
A
F
A
A
P
ATE
ETVIV
EG
SA
T
---
AP
D
D
GEN
DY
S
V
T
ST
------
SAGTKMQM
T
QR
DIPQSVT
I
VS
Q
Q
R
ME
D
QQ
LQ
TL
G
EV
M
E
NT
L
G
I
---
-
-
S
K
S
Q
A
D
S
D
R
A
LYY
SRGF
------
QI
DNYM
--
V
DGI
P
T
YFESR
WNLGDA
LS
DM
-
AL
F
ERVEVVRG
A
T
G
L
M
T
G
TG
NP
SA
AINMV
R
K
H
AT
SRE
------------
FKGDVSAEYGS
W
NK
ER
Y
VA
D
L
Q
SP
L
TE
DG
KIR
ARIVG
GY
QN
N
D
S
W
LDRYN
SE
K
TF
------
FSG
IV
D
A
DL
G
DL
T
T
LSAG
YEY
Q
RIDVNS
P
T
WGG
----
LP
RW
N
T
D
-----
GS
S
N
SYDR
AR
ST
AP
D
WAY
ND
K
EI
N
--------
K
V
FM
TLK
Q
R
FADTWQAT
L
N
AT
HSE
V
EFD
SKMMY
V
D
AY
VNKADGMLVGPYSNYGPGF
DY
V
G
GTG
WN
S
G
---------------------------
-
-
K
R
K
VDA
-------
--
-
--
-
-
---
-
L
D
LF
A
DG
IY
EL
FGR
QH
N
LMFGG
----------
SYSK
QN
N
RYFSSWANIFPD
EI
GSF
Y
N
FN
GN
F
P
QT
D
-
-
--
W
SP
-------------
----
---
------------QS
L
A
QDD
T
TH
M
KS
L
YAA
T
RVT
L
A
D
PLHLI
LG
A
R
-------
Y
----
--
-TNW
R
--------------
VDTLTY
-----
SM
EK
N
HT
----
TP
YA
GLVF
D
I
N
DNWS
T
YASYT
S
I
FQP
---------
Q
N
-
DR
D
SS
G
KY
-
L
A
P
I
TGNNYE
-------
LGLK
SDWM
N
SR
LT
T
T
L
AIF
R
I
E
Q
D
NVA
Q
S
---
T
GT
P
I
PGSN
GE
T
AYKAVDGTV
SKGVE
F
ELN
---
GA
I
T
D
NWQL
TF
GA
T
R
Y
I
AE
DN
-------
E
G
N
A
VN
PNLP
-----
RTTVKMF
T
SY
R
L
P
VMP
E
---
LT
V
G
-----
GGV
N
W
QN
--
R
VY
TDT
VT
PY
G
-
TFR
A
EQ
GSYALVDLFTRY
Q
VTK
----
NF
SLQGNVNNLFDKTY
D
TN
VE
GSIVY
-
--
-
GAPR
N
F
SI
TGTYQF
fig|481805.6.peg.2672
Escherichia coli ATCC 8739
M
L
ST
Q
F
NRDNQ
Y
QA
IT
KPS
L
LAGCI
A
LAL
L
P
S
A
A
F
A
A
P
ATE
ETVIV
EG
SA
T
---
AP
D
D
GEN
DY
S
V
T
ST
------
SAGTKMQM
T
QR
DIPQSVT
I
VS
Q
Q
R
ME
D
QQ
LQ
TL
G
EV
M
E
NT
L
G
I
---
-
-
S
K
S
Q
A
D
S
D
R
A
LYY
SRGF
------
QI
DNYM
--
V
DGI
P
T
YFESR
WNLGDA
LS
DM
-
AL
F
ERVEVVRG
A
T
G
L
M
T
G
TG
NP
SA
AINMV
R
K
H
AT
SRE
------------
FKGDVSAEYGS
W
NK
ER
Y
VA
D
L
Q
SP
L
TE
DG
KIR
ARIVG
GY
QN
N
D
S
W
LDRYN
SE
K
TF
------
FSG
IV
D
A
DL
G
DL
T
T
LSAG
YEY
Q
RIDVNS
P
T
WGG
----
LP
RW
N
T
D
-----
GS
S
N
SYDR
AR
ST
AP
D
WAY
ND
K
EI
N
--------
K
V
FM
TLK
Q
R
FADTWQAT
L
N
AT
HSE
V
EFD
SKMMY
V
D
AY
VNKADGMLVGPYSNYGPGF
DY
V
G
GTG
WN
S
G
---------------------------
-
-
K
R
K
VDA
-------
--
-
--
-
-
---
-
L
D
LF
A
DG
IY
EL
FGR
QH
N
LMFGG
----------
SYSK
QN
N
RYFSSWANIFPD
EI
GSF
Y
N
FN
GN
F
P
QT
D
-
-
--
W
SP
-------------
----
---
------------QS
L
A
QDD
T
TH
M
KS
L
YAA
T
RVT
L
A
D
PLHLI
LG
A
R
-------
Y
----
--
-TNW
R
--------------
VDTLTY
-----
SM
EK
N
HT
----
TP
YA
GLVF
D
I
N
DNWS
T
YASYT
S
I
FQP
---------
Q
N
-
DR
D
SS
G
KY
-
L
A
P
I
TGNNYE
-------
LGLK
SDWM
N
SR
LT
T
T
L
AIF
R
I
E
Q
D
NVA
Q
S
---
T
GT
P
I
PGSN
GE
T
AYKAVDGTV
SKGVE
F
ELN
---
GA
I
T
D
NWQL
TF
GA
T
R
Y
I
AE
DN
-------
E
G
N
A
VN
PNLP
-----
RTTVKMF
T
SY
R
L
P
VMP
E
---
LT
V
G
-----
GGV
N
W
QN
--
R
VY
TDT
VT
PY
G
-
TFR
A
EQ
GSYALVDLFTRY
Q
VTK
----
NF
SLQGNVNNLFDKTY
D
TN
VE
GSIVY
-
--
-
GAPR
N
F
SI
TGTYQF
fig|413997.3.peg.1156
Escherichia coli B str. REL606
M
L
ST
Q
F
NRDNQ
Y
QA
IT
KPS
L
LAGCI
A
LAL
L
P
S
A
A
F
A
A
P
ATE
ETVIV
EG
SA
T
---
AP
D
D
GEN
DY
S
V
T
ST
------
SAGTKMQM
T
QR
DIPQSVT
I
VS
Q
Q
R
ME
D
QQ
LQ
TL
G
EV
M
E
NT
L
G
I
---
-
-
S
K
S
Q
A
D
S
D
R
A
LYY
SRGF
------
QI
DNYM
--
V
DGI
P
T
YFESR
WNLGDA
LS
DM
-
AL
F
ERVEVVRG
A
T
G
L
M
T
G
TG
NP
SA
AINMV
R
K
H
AT
SRE
------------
FKGDVSAEYGS
W
NK
ER
Y
VA
D
L
Q
SP
L
TE
DG
KIR
ARIVG
GY
QN
N
D
S
W
LDRYN
SE
K
TF
------
FSG
IV
D
A
DL
G
DL
T
T
LSAG
YEY
Q
RIDVNS
P
T
WGG
----
LP
RW
N
T
D
-----
GS
S
N
SYDR
AR
ST
AP
D
WAY
ND
K
EI
N
--------
K
V
FM
TLK
Q
R
FADTWQAT
L
N
AT
HSE
V
EFD
SKMMY
V
D
AY
VNKADGMLVGPYSNYGPGF
DY
V
G
GTG
WN
S
G
---------------------------
-
-
K
R
K
VDA
-------
--
-
--
-
-
---
-
L
D
LF
A
DG
IY
EL
FGR
QH
N
LMFGG
----------
SYSK
QN
N
RYFSSWANIFPD
EI
GSF
Y
N
FN
GN
F
P
QT
D
-
-
--
W
SP
-------------
----
---
------------QS
L
A
QDD
T
TH
M
KS
L
YAA
T
RVT
L
A
D
PLHLI
LG
A
R
-------
Y
----
--
-TNW
R
--------------
VDTLTY
-----
SM
EK
N
HT
----
TP
YA
GLVF
D
I
N
DNWS
T
YASYT
S
I
FQP
---------
Q
N
-
DR
D
SS
G
KY
-
L
A
P
I
TGNNYE
-------
LGLK
SDWM
N
SR
LT
T
T
L
AIF
R
I
E
Q
D
NVA
Q
S
---
T
GT
P
I
PGSN
GE
T
AYKAVDGTV
SKGVE
F
ELN
---
GA
I
T
D
NWQL
TF
GA
T
R
Y
I
AE
DN
-------
E
G
N
A
VN
PNLP
-----
RTTVKMF
T
SY
R
L
P
VMP
E
---
LT
V
G
-----
GGV
N
W
QN
--
R
VY
TDT
VT
PY
G
-
TFR
A
EQ
GSYALVDLFTRY
Q
VTK
----
NF
SLQGNVNNLFDKTY
D
TN
VE
GSIVY
-
--
-
GAPR
N
F
SI
TGTYQF
fig|511693.5.peg.1185
Escherichia coli BL21
M
L
ST
Q
F
NRDNQ
Y
QA
IT
KPS
L
LAGCI
A
LAL
L
P
S
A
A
F
A
A
P
ATE
ETVIV
EG
SA
T
---
AP
D
D
GEN
DY
S
V
T
ST
------
SAGTKMQM
T
QR
DIPQSVT
I
VS
Q
Q
R
ME
D
QQ
LQ
TL
G
EV
M
E
NT
L
G
I
---
-
-
S
K
S
Q
A
D
S
D
R
A
LYY
SRGF
------
QI
DNYM
--
V
DGI
P
T
YFESR
WNLGDA
LS
DM
-
AL
F
ERVEVVRG
A
T
G
L
M
T
G
TG
NP
SA
AINMV
R
K
H
AT
SRE
------------
FKGDVSAEYGS
W
NK
ER
Y
VA
D
L
Q
SP
L
TE
DG
KIR
ARIVG
GY
QN
N
D
S
W
LDRYN
SE
K
TF
------
FSG
IV
D
A
DL
G
DL
T
T
LSAG
YEY
Q
RIDVNS
P
T
WGG
----
LP
RW
N
T
D
-----
GS
S
N
SYDR
AR
ST
AP
D
WAY
ND
K
EI
N
--------
K
V
FM
TLK
Q
R
FADTWQAT
L
N
AT
HSE
V
EFD
SKMMY
V
D
AY
VNKADGMLVGPYSNYGPGF
DY
V
G
GTG
WN
S
G
---------------------------
-
-
K
R
K
VDA
-------
--
-
--
-
-
---
-
L
D
LF
A
DG
IY
EL
FGR
QH
N
LMFGG
----------
SYSK
QN
N
RYFSSWANIFPD
EI
GSF
Y
N
FN
GN
F
P
QT
D
-
-
--
W
SP
-------------
----
---
------------QS
L
A
QDD
T
TH
M
KS
L
YAA
T
RVT
L
A
D
PLHLI
LG
A
R
-------
Y
----
--
-TNW
R
--------------
VDTLTY
-----
SM
EK
N
HT
----
TP
YA
GLVF
D
I
N
DNWS
T
YASYT
S
I
FQP
---------
Q
N
-
DR
D
SS
G
KY
-
L
A
P
I
TGNNYE
-------
LGLK
SDWM
N
SR
LT
T
T
L
AIF
R
I
E
Q
D
NVA
Q
S
---
T
GT
P
I
PGSN
GE
T
AYKAVDGTV
SKGVE
F
ELN
---
GA
I
T
D
NWQL
TF
GA
T
R
Y
I
AE
DN
-------
E
G
N
A
VN
PNLP
-----
RTTVKMF
T
SY
R
L
P
VMP
E
---
LT
V
G
-----
GGV
N
W
QN
--
R
VY
TDT
VT
PY
G
-
TFR
A
EQ
GSYALVDLFTRY
Q
VTK
----
NF
SLQGNVNNLFDKTY
D
TN
VE
GSIVY
-
--
-
GAPR
N
F
SI
TGTYQF
fig|469008.4.peg.2580
Escherichia coli BL21(DE3)
M
L
ST
Q
F
NRDNQ
Y
QA
IT
KPS
L
LAGCI
A
LAL
L
P
S
A
A
F
A
A
P
ATE
ETVIV
EG
SA
T
---
AP
D
D
GEN
DY
S
V
T
ST
------
SAGTKMQM
T
QR
DIPQSVT
I
VS
Q
Q
R
ME
D
QQ
LQ
TL
G
EV
M
E
NT
L
G
I
---
-
-
S
K
S
Q
A
D
S
D
R
A
LYY
SRGF
------
QI
DNYM
--
V
DGI
P
T
YFESR
WNLGDA
LS
DM
-
AL
F
ERVEVVRG
A
T
G
L
M
T
G
TG
NP
SA
AINMV
R
K
H
AT
SRE
------------
FKGDVSAEYGS
W
NK
ER
Y
VA
D
L
Q
SP
L
TE
DG
KIR
ARIVG
GY
QN
N
D
S
W
LDRYN
SE
K
TF
------
FSG
IV
D
A
DL
G
DL
T
T
LSAG
YEY
Q
RIDVNS
P
T
WGG
----
LP
RW
N
T
D
-----
GS
S
N
SYDR
AR
ST
AP
D
WAY
ND
K
EI
N
--------
K
V
FM
TLK
Q
R
FADTWQAT
L
N
AT
HSE
V
EFD
SKMMY
V
D
AY
VNKADGMLVGPYSNYGPGF
DY
V
G
GTG
WN
S
G
---------------------------
-
-
K
R
K
VDA
-------
--
-
--
-
-
---
-
L
D
LF
A
DG
IY
EL
FGR
QH
N
LMFGG
----------
SYSK
QN
N
RYFSSWANIFPD
EI
GSF
Y
N
FN
GN
F
P
QT
D
-
-
--
W
SP
-------------
----
---
------------QS
L
A
QDD
T
TH
M
KS
L
YAA
T
RVT
L
A
D
PLHLI
LG
A
R
-------
Y
----
--
-TNW
R
--------------
VDTLTY
-----
SM
EK
N
HT
----
TP
YA
GLVF
D
I
N
DNWS
T
YASYT
S
I
FQP
---------
Q
N
-
DR
D
SS
G
KY
-
L
A
P
I
TGNNYE
-------
LGLK
SDWM
N
SR
LT
T
T
L
AIF
R
I
E
Q
D
NVA
Q
S
---
T
GT
P
I
PGSN
GE
T
AYKAVDGTV
SKGVE
F
ELN
---
GA
I
T
D
NWQL
TF
GA
T
R
Y
I
AE
DN
-------
E
G
N
A
VN
PNLP
-----
RTTVKMF
T
SY
R
L
P
VMP
E
---
LT
V
G
-----
GGV
N
W
QN
--
R
VY
TDT
VT
PY
G
-
TFR
A
EQ
GSYALVDLFTRY
Q
VTK
----
NF
SLQGNVNNLFDKTY
D
TN
VE
GSIVY
-
--
-
GAPR
N
F
SI
TGTYQF
fig|331112.3.peg.1141
Escherichia coli HS
M
L
ST
Q
F
NRDNQ
Y
QA
IT
KPS
L
LAGCI
A
LAL
L
P
S
A
A
F
A
A
P
ATE
ETVIV
EG
SA
T
---
AP
D
D
GEN
DY
S
V
T
ST
------
SAGTKMQM
T
QR
DIPQSVT
I
VS
Q
Q
R
ME
D
QQ
LQ
TL
G
EV
M
E
NT
L
G
I
---
-
-
S
K
S
Q
A
D
S
D
R
A
LYY
SRGF
------
QI
DNYM
--
V
DGI
P
T
YFESR
WNLGDA
LS
DM
-
AL
F
ERVEVVRG
A
T
G
L
M
T
G
TG
NP
SA
AINMV
R
K
H
AT
SRE
------------
FKGDVSAEYGS
W
NK
ER
Y
VA
D
L
Q
SP
L
TE
DG
KIR
ARIVG
GY
QN
N
D
S
W
LDRYN
SE
K
TF
------
FSG
IV
D
A
DL
G
DL
T
T
LSAG
YEY
Q
RIDVNS
P
T
WGG
----
LP
RW
N
T
D
-----
GS
S
N
SYDR
AR
ST
AP
D
WAY
ND
K
EI
N
--------
K
V
FM
TLK
Q
R
FADTWQAT
L
N
AT
HSE
V
EFD
SKMMY
V
D
AY
VNKADGMLVGPYSNYGPGF
DY
V
G
GTG
WN
S
G
---------------------------
-
-
K
R
K
VDA
-------
--
-
--
-
-
---
-
L
D
LF
A
DG
IY
EL
FGR
QH
N
LMFGG
----------
SYSK
QN
N
RYFSSWANIFPD
EI
GSF
Y
N
FN
GN
F
P
QT
D
-
-
--
W
SP
-------------
----
---
------------QS
L
A
QDD
T
TH
M
KS
L
YAA
T
RVT
L
A
D
PLHLI
LG
A
R
-------
Y
----
--
-TNW
R
--------------
VDTLTY
-----
SM
EK
N
HT
----
TP
YA
GLVF
D
I
N
DNWS
T
YASYT
S
I
FQP
---------
Q
N
-
DR
D
SS
G
KY
-
L
A
P
I
TGNNYE
-------
LGLK
SDWM
N
SR
LT
T
T
L
AIF
R
I
E
Q
D
NVA
Q
S
---
T
GT
P
I
PGSN
GE
T
AYKAVDGTV
SKGVE
F
ELN
---
GA
I
T
D
NWQL
TF
GA
T
R
Y
I
AE
DN
-------
E
G
N
A
VN
PNLP
-----
RTTVKMF
T
SY
R
L
P
VMP
E
---
LT
V
G
-----
GGV
N
W
QN
--
R
VY
TDT
VT
PY
G
-
TFR
A
EQ
GSYALVDLFTRY
Q
VTK
----
NF
SLQGNVNNLFDKTY
D
TN
VE
GSIVY
-
--
-
GAPR
N
F
SI
TGTYQF
fig|331112.6.peg.1190
Escherichia coli HS
M
L
ST
Q
F
NRDNQ
Y
QA
IT
KPS
L
LAGCI
A
LAL
L
P
S
A
A
F
A
A
P
ATE
ETVIV
EG
SA
T
---
AP
D
D
GEN
DY
S
V
T
ST
------
SAGTKMQM
T
QR
DIPQSVT
I
VS
Q
Q
R
ME
D
QQ
LQ
TL
G
EV
M
E
NT
L
G
I
---
-
-
S
K
S
Q
A
D
S
D
R
A
LYY
SRGF
------
QI
DNYM
--
V
DGI
P
T
YFESR
WNLGDA
LS
DM
-
AL
F
ERVEVVRG
A
T
G
L
M
T
G
TG
NP
SA
AINMV
R
K
H
AT
SRE
------------
FKGDVSAEYGS
W
NK
ER
Y
VA
D
L
Q
SP
L
TE
DG
KIR
ARIVG
GY
QN
N
D
S
W
LDRYN
SE
K
TF
------
FSG
IV
D
A
DL
G
DL
T
T
LSAG
YEY
Q
RIDVNS
P
T
WGG
----
LP
RW
N
T
D
-----
GS
S
N
SYDR
AR
ST
AP
D
WAY
ND
K
EI
N
--------
K
V
FM
TLK
Q
R
FADTWQAT
L
N
AT
HSE
V
EFD
SKMMY
V
D
AY
VNKADGMLVGPYSNYGPGF
DY
V
G
GTG
WN
S
G
---------------------------
-
-
K
R
K
VDA
-------
--
-
--
-
-
---
-
L
D
LF
A
DG
IY
EL
FGR
QH
N
LMFGG
----------
SYSK
QN
N
RYFSSWANIFPD
EI
GSF
Y
N
FN
GN
F
P
QT
D
-
-
--
W
SP
-------------
----
---
------------QS
L
A
QDD
T
TH
M
KS
L
YAA
T
RVT
L
A
D
PLHLI
LG
A
R
-------
Y
----
--
-TNW
R
--------------
VDTLTY
-----
SM
EK
N
HT
----
TP
YA
GLVF
D
I
N
DNWS
T
YASYT
S
I
FQP
---------
Q
N
-
DR
D
SS
G
KY
-
L
A
P
I
TGNNYE
-------
LGLK
SDWM
N
SR
LT
T
T
L
AIF
R
I
E
Q
D
NVA
Q
S
---
T
GT
P
I
PGSN
GE
T
AYKAVDGTV
SKGVE
F
ELN
---
GA
I
T
D
NWQL
TF
GA
T
R
Y
I
AE
DN
-------
E
G
N
A
VN
PNLP
-----
RTTVKMF
T
SY
R
L
P
VMP
E
---
LT
V
G
-----
GGV
N
W
QN
--
R
VY
TDT
VT
PY
G
-
TFR
A
EQ
GSYALVDLFTRY
Q
VTK
----
NF
SLQGNVNNLFDKTY
D
TN
VE
GSIVY
-
--
-
GAPR
N
F
SI
TGTYQF
fig|749537.3.peg.2362
Escherichia coli MS 115-1
M
L
ST
Q
F
NRDNQ
Y
QA
IT
KPS
L
LAGCI
A
LAL
L
P
S
A
A
F
A
A
P
ATE
ETVIV
EG
SA
T
---
AP
D
D
GEN
DY
S
V
T
ST
------
SAGTKMQM
T
QR
DIPQSVT
I
VS
Q
Q
R
ME
D
QQ
LQ
TL
G
EV
M
E
NT
L
G
I
---
-
-
S
K
S
Q
A
D
S
D
R
A
LYY
SRGF
------
QI
DNYM
--
V
DGI
P
T
YFESR
WNLGDA
LS
DM
-
AL
F
ERVEVVRG
A
T
G
L
M
T
G
TG
NP
SA
AINMV
R
K
H
AT
SRE
------------
FKGDVSAEYGS
W
NK
ER
Y
VA
D
L
Q
SP
L
TE
DG
KIR
ARIVG
GY
QN
N
D
S
W
LDRYN
SE
K
TF
------
FSG
IV
D
A
DL
G
DL
T
T
LSAG
YEY
Q
RIDVNS
P
T
WGG
----
LP
RW
N
T
D
-----
GS
S
N
SYDR
AR
ST
AP
D
WAY
ND
K
EI
N
--------
K
V
FM
TLK
Q
R
FADTWQAT
L
N
AT
HSE
V
EFD
SKMMY
V
D
AY
VNKADGMLVGPYSNYGPGF
DY
V
G
GTG
WN
S
G
---------------------------
-
-
K
R
K
VDA
-------
--
-
--
-
-
---
-
L
D
LF
A
DG
IY
EL
FGR
QH
N
LMFGG
----------
SYSK
QN
N
RYFSSWANIFPD
EI
GSF
Y
N
FN
GN
F
P
QT
D
-
-
--
W
SP
-------------
----
---
------------QS
L
A
QDD
T
TH
M
KS
L
YAA
T
RVT
L
A
D
PLHLI
LG
A
R
-------
Y
----
--
-TNW
R
--------------
VDTLTY
-----
SM
EK
N
HT
----
TP
YA
GLVF
D
I
N
DNWS
T
YASYT
S
I
FQP
---------
Q
N
-
DR
D
SS
G
KY
-
L
A
P
I
TGNNYE
-------
LGLK
SDWM
N
SR
LT
T
T
L
AIF
R
I
E
Q
D
NVA
Q
S
---
T
GT
P
I
PGSN
GE
T
AYKAVDGTV
SKGVE
F
ELN
---
GA
I
T
D
NWQL
TF
GA
T
R
Y
I
AE
DN
-------
E
G
N
A
VN
PNLP
-----
RTTVKMF
T
SY
R
L
P
VMP
E
---
LT
V
G
-----
GGV
N
W
QN
--
R
VY
TDT
VT
PY
G
-
TFR
A
EQ
GSYALVDLFTRY
Q
VTK
----
NF
SLQGNVNNLFDKTY
D
TN
VE
GSIVY
-
--
-
GAPR
N
F
SI
TGTYQF
fig|679205.4.peg.4129
Escherichia coli MS 124-1
M
L
ST
Q
F
NRDNQ
Y
QA
IT
KPS
L
LAGCI
A
LAL
L
P
S
A
A
F
A
A
P
ATE
ETVIV
EG
SA
T
---
AP
D
D
GEN
DY
S
V
T
ST
------
SAGTKMQM
T
QR
DIPQSVT
I
VS
Q
Q
R
ME
D
QQ
LQ
TL
G
EV
M
E
NT
L
G
I
---
-
-
S
K
S
Q
A
D
S
D
R
A
LYY
SRGF
------
QI
DNYM
--
V
DGI
P
T
YFESR
WNLGDA
LS
DM
-
AL
F
ERVEVVRG
A
T
G
L
M
T
G
TG
NP
SA
AINMV
R
K
H
AT
SRE
------------
FKGDVSAEYGS
W
NK
ER
Y
VA
D
L
Q
SP
L
TE
DG
KIR
ARIVG
GY
QN
N
D
S
W
LDRYN
SE
K
TF
------
FSG
IV
D
A
DL
G
DL
T
T
LSAG
YEY
Q
RIDVNS
P
T
WGG
----
LP
RW
N
T
D
-----
GS
S
N
SYDR
AR
ST
AP
D
WAY
ND
K
EI
N
--------
K
V
FM
TLK
Q
R
FADTWQAT
L
N
AT
HSE
V
EFD
SKMMY
V
D
AY
VNKADGMLVGPYSNYGPGF
DY
V
G
GTG
WN
S
G
---------------------------
-
-
K
R
K
VDA
-------
--
-
--
-
-
---
-
L
D
LF
A
DG
IY
EL
FGR
QH
N
LMFGG
----------
SYSK
QN
N
RYFSSWANIFPD
EI
GSF
Y
N
FN
GN
F
P
QT
D
-
-
--
W
SP
-------------
----
---
------------QS
L
A
QDD
T
TH
M
KS
L
YAA
T
RVT
L
A
D
PLHLI
LG
A
R
-------
Y
----
--
-TNW
R
--------------
VDTLTY
-----
SM
EK
N
HT
----
TP
YA
GLVF
D
I
N
DNWS
T
YASYT
S
I
FQP
---------
Q
N
-
DR
D
SS
G
KY
-
L
A
P
I
TGNNYE
-------
LGLK
SDWM
N
SR
LT
T
T
L
AIF
R
I
E
Q
D
NVA
Q
S
---
T
GT
P
I
PGSN
GE
T
AYKAVDGTV
SKGVE
F
ELN
---
GA
I
T
D
NWQL
TF
GA
T
R
Y
I
AE
DN
-------
E
G
N
A
VN
PNLP
-----
RTTVKMF
T
SY
R
L
P
VMP
E
---
LT
V
G
-----
GGV
N
W
QN
--
R
VY
TDT
VT
PY
G
-
TFR
A
EQ
GSYALVDLFTRY
Q
VTK
----
NF
SLQGNVNNLFDKTY
D
TN
VE
GSIVY
-
--
-
GAPR
N
F
SI
TGTYQF
fig|749533.3.peg.630
Escherichia coli MS 84-1
M
L
ST
Q
F
NRDNQ
Y
QA
IT
KPS
L
LAGCI
A
LAL
L
P
S
A
A
F
A
A
P
ATE
ETVIV
EG
SA
T
---
AP
D
D
GEN
DY
S
V
T
ST
------
SAGTKMQM
T
QR
DIPQSVT
I
VS
Q
Q
R
ME
D
QQ
LQ
TL
G
EV
M
E
NT
L
G
I
---
-
-
S
K
S
Q
A
D
S
D
R
A
LYY
SRGF
------
QI
DNYM
--
V
DGI
P
T
YFESR
WNLGDA
LS
DM
-
AL
F
ERVEVVRG
A
T
G
L
M
T
G
TG
NP
SA
AINMV
R
K
H
AT
SRE
------------
FKGDVSAEYGS
W
NK
ER
Y
VA
D
L
Q
SP
L
TE
DG
KIR
ARIVG
GY
QN
N
D
S
W
LDRYN
SE
K
TF
------
FSG
IV
D
A
DL
G
DL
T
T
LSAG
YEY
Q
RIDVNS
P
T
WGG
----
LP
RW
N
T
D
-----
GS
S
N
SYDR
AR
ST
AP
D
WAY
ND
K
EI
N
--------
K
V
FM
TLK
Q
R
FADTWQAT
L
N
AT
HSE
V
EFD
SKMMY
V
D
AY
VNKADGMLVGPYSNYGPGF
DY
V
G
GTG
WN
S
G
---------------------------
-
-
K
R
K
VDA
-------
--
-
--
-
-
---
-
L
D
LF
A
DG
IY
EL
FGR
QH
N
LMFGG
----------
SYSK
QN
N
RYFSSWANIFPD
EI
GSF
Y
N
FN
GN
F
P
QT
D
-
-
--
W
SP
-------------
----
---
------------QS
L
A
QDD
T
TH
M
KS
L
YAA
T
RVT
L
A
D
PLHLI
LG
A
R
-------
Y
----
--
-TNW
R
--------------
VDTLTY
-----
SM
EK
N
HT
----
TP
YA
GLVF
D
I
N
DNWS
T
YASYT
S
I
FQP
---------
Q
N
-
DR
D
SS
G
KY
-
L
A
P
I
TGNNYE
-------
LGLK
SDWM
N
SR
LT
T
T
L
AIF
R
I
E
Q
D
NVA
Q
S
---
T
GT
P
I
PGSN
GE
T
AYKAVDGTV
SKGVE
F
ELN
---
GA
I
T
D
NWQL
TF
GA
T
R
Y
I
AE
DN
-------
E
G
N
A
VN
PNLP
-----
RTTVKMF
T
SY
R
L
P
VMP
E
---
LT
V
G
-----
GGV
N
W
QN
--
R
VY
TDT
VT
PY
G
-
TFR
A
EQ
GSYALVDLFTRY
Q
VTK
----
NF
SLQGNVNNLFDKTY
D
TN
VE
GSIVY
-
--
-
GAPR
N
F
SI
TGTYQF
fig|340184.3.peg.3693
Escherichia coli B7A
M
L
ST
Q
F
NRDNQ
Y
QA
IT
KPS
L
LAGCI
A
LAL
L
P
S
A
A
F
A
A
P
ATE
ETVIV
EG
SA
T
---
AP
D
D
GEN
DY
S
V
T
ST
------
SAGTKMQM
T
QR
DIPQSVT
I
VS
Q
Q
R
ME
D
QQ
LQ
TL
G
EV
M
E
NT
Q
G
I
---
-
-
S
K
S
Q
A
D
S
D
R
A
LYY
SRGF
------
QI
DNYM
--
V
DGI
P
T
YFESR
WNLGDA
LS
DM
-
AL
F
ERVEVVRG
A
T
G
L
M
T
G
TG
NP
SA
AINMV
R
K
H
AT
SRE
------------
FKGDVSAEYGS
W
NK
ER
Y
VA
D
L
Q
SP
L
TE
DG
KIR
ARIVG
GY
QN
N
D
S
W
LDRYN
SE
K
TF
------
FSG
IV
D
A
DL
G
DL
T
T
LSAG
YEY
Q
RIDVNS
P
T
WGG
----
LP
RW
N
T
D
-----
GS
S
N
SYDR
AR
ST
AP
D
WAY
ND
K
EI
N
--------
K
V
FM
TLK
Q
R
FADTWQAT
L
N
AT
HSE
V
EFD
SKMMY
V
D
AY
VNKADGMLVGPYSNYGPGF
DY
V
G
GTG
WN
S
G
---------------------------
-
-
K
R
K
VDA
-------
--
-
--
-
-
---
-
L
D
LF
A
DG
IY
EL
FGR
QH
N
LMFGG
----------
SYSK
QN
N
RYFSSWANIFPD
EI
GSF
Y
N
FN
GN
F
P
QT
D
-
-
--
W
SP
-------------
----
---
------------QS
L
A
QDD
T
TH
M
KS
L
YAA
T
RVT
L
A
D
PLHLI
LG
A
R
-------
Y
----
--
-TNW
R
--------------
VDTLTY
-----
SM
EK
N
HT
----
TP
YA
GLVF
D
I
N
DNWS
T
YASYT
S
I
FQP
---------
Q
N
-
DR
D
SS
G
KY
-
L
A
P
I
TGNNYE
-------
LGLK
SDWM
N
SR
LT
T
T
L
AIF
R
I
E
Q
D
NVA
Q
S
---
T
GT
P
I
PGSN
GE
T
AYKAVDGTV
SKGVE
F
ELN
---
GA
I
T
D
NWQL
TF
GA
T
R
Y
I
AE
DN
-------
E
G
N
A
VN
PNLP
-----
RTTVKMF
T
SY
R
L
P
VMP
E
---
LT
V
G
-----
GGV
N
W
QN
--
R
VY
TDT
VT
PY
G
-
TFR
A
EQ
GSYALVDLFTRY
Q
VTK
----
NF
SLQGNVNNLFDKTY
D
TN
VE
GSIVY
-
--
-
GAPR
N
F
SI
TGTYQF
fig|340184.6.peg.3857
Escherichia coli B7A
M
L
ST
Q
F
NRDNQ
Y
QA
IT
KPS
L
LAGCI
A
LAL
L
P
S
A
A
F
A
A
P
ATE
ETVIV
EG
SA
T
---
AP
D
D
GEN
DY
S
V
T
ST
------
SAGTKMQM
T
QR
DIPQSVT
I
VS
Q
Q
R
ME
D
QQ
LQ
TL
G
EV
M
E
NT
Q
G
I
---
-
-
S
K
S
Q
A
D
S
D
R
A
LYY
SRGF
------
QI
DNYM
--
V
DGI
P
T
YFESR
WNLGDA
LS
DM
-
AL
F
ERVEVVRG
A
T
G
L
M
T
G
TG
NP
SA
AINMV
R
K
H
AT
SRE
------------
FKGDVSAEYGS
W
NK
ER
Y
VA
D
L
Q
SP
L
TE
DG
KIR
ARIVG
GY
QN
N
D
S
W
LDRYN
SE
K
TF
------
FSG
IV
D
A
DL
G
DL
T
T
LSAG
YEY
Q
RIDVNS
P
T
WGG
----
LP
RW
N
T
D
-----
GS
S
N
SYDR
AR
ST
AP
D
WAY
ND
K
EI
N
--------
K
V
FM
TLK
Q
R
FADTWQAT
L
N
AT
HSE
V
EFD
SKMMY
V
D
AY
VNKADGMLVGPYSNYGPGF
DY
V
G
GTG
WN
S
G
---------------------------
-
-
K
R
K
VDA
-------
--
-
--
-
-
---
-
L
D
LF
A
DG
IY
EL
FGR
QH
N
LMFGG
----------
SYSK
QN
N
RYFSSWANIFPD
EI
GSF
Y
N
FN
GN
F
P
QT
D
-
-
--
W
SP
-------------
----
---
------------QS
L
A
QDD
T
TH
M
KS
L
YAA
T
RVT
L
A
D
PLHLI
LG
A
R
-------
Y
----
--
-TNW
R
--------------
VDTLTY
-----
SM
EK
N
HT
----
TP
YA
GLVF
D
I
N
DNWS
T
YASYT
S
I
FQP
---------
Q
N
-
DR
D
SS
G
KY
-
L
A
P
I
TGNNYE
-------
LGLK
SDWM
N
SR
LT
T
T
L
AIF
R
I
E
Q
D
NVA
Q
S
---
T
GT
P
I
PGSN
GE
T
AYKAVDGTV
SKGVE
F
ELN
---
GA
I
T
D
NWQL
TF
GA
T
R
Y
I
AE
DN
-------
E
G
N
A
VN
PNLP
-----
RTTVKMF
T
SY
R
L
P
VMP
E
---
LT
V
G
-----
GGV
N
W
QN
--
R
VY
TDT
VT
PY
G
-
TFR
A
EQ
GSYALVDLFTRY
Q
VTK
----
NF
SLQGNVNNLFDKTY
D
TN
VE
GSIVY
-
--
-
GAPR
N
F
SI
TGTYQF
fig|550672.3.peg.1380
Escherichia coli B088
M
L
ST
Q
F
NRDNQ
Y
QA
ST
KPS
L
LAGCI
A
LAL
L
P
S
A
A
F
A
A
P
ATE
ETVIV
EG
SA
T
---
AP
D
D
GEN
DY
S
V
T
ST
------
SAGTKMQM
T
QR
DIPQSVT
I
VS
Q
Q
R
ME
D
QQ
LQ
TL
G
EV
M
E
NT
L
G
I
---
-
-
S
K
S
Q
A
D
S
D
R
A
LYY
SRGF
------
QI
DNYM
--
V
DGI
P
T
YFESR
WNLGDA
LS
DM
-
AL
F
ERVEVVRG
A
T
G
L
M
T
G
TG
NP
SA
AINMV
R
K
H
AT
SRE
------------
FKGDVSAEYGS
W
NK
ER
Y
VA
D
L
Q
SP
L
TE
DG
KIR
ARIVG
GY
QN
N
D
S
W
LDRYN
SE
K
TF
------
FSG
IV
D
A
DL
G
DL
T
T
LSAG
YEY
Q
RIDVNS
P
T
WGG
----
LP
RW
N
T
D
-----
GS
S
N
SYDR
AR
ST
AP
D
WAY
ND
K
EI
N
--------
K
V
FM
TLK
Q
R
FADTWQAT
L
N
AT
HSE
V
EFD
SKMMY
V
D
AY
VNKADGMLVGPYSNYGPGF
DY
V
G
GTG
WN
S
G
---------------------------
-
-
K
R
K
VDA
-------
--
-
--
-
-
---
-
L
D
LF
A
DG
IY
EL
FGR
QH
N
LMFGG
----------
SYSK
QN
N
RYFSSWANIFPD
EI
GSF
Y
N
FN
GN
F
P
QT
D
-
-
--
W
SP
-------------
----
---
------------QS
L
A
QDD
T
TH
M
KS
L
YAA
T
RVT
L
A
D
PLHLI
LG
A
R
-------
Y
----
--
-TNW
R
--------------
VDTLTY
-----
SM
EK
N
HT
----
TP
YA
GLVF
D
I
N
DNWS
T
YASYT
S
I
FQP
---------
Q
N
-
DR
D
SS
G
KY
-
L
A
P
I
TGNNYE
-------
LGLK
SDWM
N
SR
LT
T
T
L
AIF
R
I
E
Q
D
NVA
Q
S
---
T
GT
P
I
PGSN
GE
T
AYKAVDGTV
SKGVE
F
ELN
---
GA
I
T
D
NWQL
TF
GA
T
R
Y
I
AE
DN
-------
E
G
N
A
VN
PNLP
-----
RTTVKMF
T
SY
R
L
P
VMP
E
---
LT
V
G
-----
GGV
N
W
QN
--
R
VY
TDT
VT
PY
G
-
TFR
A
EQ
GSYALVDLFTRY
Q
VTK
----
NF
SLQGNVNNLFDKTY
D
TN
VE
GSIVY
-
--
-
G
T
PR
N
F
SI
TGTYQF
fig|562.371.peg.4071
Escherichia coli 1044A
M
L
ST
Q
F
NRDNQ
Y
QA
IT
KPS
L
LAGCI
A
LAL
L
P
S
A
A
F
A
A
P
ATE
ETVIV
EG
SA
T
---
AP
D
D
GEN
DY
S
V
T
ST
------
SAGTKMQM
T
QR
DIPQSVT
I
VS
Q
Q
R
ME
D
QQ
LQ
TL
G
EV
M
E
NT
L
G
I
---
-
-
S
K
S
Q
A
D
S
D
R
A
LYY
SRGF
------
QI
DNYM
--
V
DGI
P
T
YFESR
WNLGDA
LS
DM
-
AL
F
ERVEVVRG
A
T
G
L
M
T
G
TG
NP
SA
AINMV
R
K
H
AT
SRE
------------
FKGDVSAEYGS
W
NK
ER
Y
VA
D
L
Q
SP
L
TE
DG
KIR
ARIVG
GY
QN
N
D
S
W
LDRYN
SE
K
TF
------
FSG
IV
D
A
DL
G
DL
T
T
LSAG
YEY
Q
RIDVNS
P
T
WGG
----
LP
RW
N
T
D
-----
GS
S
N
SYDR
AR
ST
AP
D
WAY
ND
K
EI
N
--------
K
V
FM
TLK
Q
R
FADTWQAT
L
N
AT
HSE
V
EFD
SKMMY
V
D
AY
VNKADGMLVGPYSNYGPGF
DY
V
G
GTG
WN
S
G
---------------------------
-
-
K
R
K
VDA
-------
--
-
--
-
-
---
-
L
D
LF
A
DG
SY
EL
FGR
QH
N
LMFGG
----------
SYSK
QN
N
RYFSSWANIFPD
EI
GSF
Y
N
FN
GN
F
P
QT
D
-
-
--
W
SP
-------------
----
---
------------QS
L
A
QDD
T
TH
M
KS
L
YAA
T
RVT
L
A
D
PLHLI
LG
A
R
-------
Y
----
--
-TNW
R
--------------
VDTLTY
-----
SM
EK
N
HT
----
TP
YA
GLVF
D
I
N
DNWS
T
YASYT
S
I
FQP
---------
Q
N
-
DR
D
SS
G
KY
-
L
A
P
I
TGNNYE
-------
LGLK
SDWM
N
SR
LT
T
T
L
AIF
R
I
E
Q
D
NVA
Q
S
---
T
GT
P
I
PGSN
GE
T
AYKAVDGTV
SKGVE
F
ELN
---
GA
I
T
D
NWQL
TF
GA
T
R
Y
I
AE
DN
-------
E
G
N
A
VN
PNLP
-----
RTTVKMF
T
SY
R
L
P
VMP
E
---
LT
V
G
-----
GGV
N
W
QN
--
R
VY
TDT
VT
PY
G
-
TFR
A
EQ
GSYALVDLFTRY
Q
VTK
----
NF
SLQGNVNNLFDKTY
D
TN
VE
GSIVY
-
--
-
GAPR
N
F
SI
TGTYQF
fig|562.373.peg.4844
Escherichia coli 1125A
M
L
ST
Q
F
NRDNQ
Y
QA
IT
KPS
L
LAGCI
A
LAL
L
P
S
A
A
F
A
A
P
ATE
ETVIV
EG
SA
T
---
AP
D
D
GEN
DY
S
V
T
ST
------
SAGTKMQM
T
QR
DIPQSVT
I
VS
Q
Q
R
ME
D
QQ
LQ
TL
G
EV
M
E
NT
L
G
I
---
-
-
S
K
S
Q
A
D
S
D
R
A
LYY
SRGF
------
QI
DNYM
--
V
DGI
P
T
YFESR
WNLGDA
LS
DM
-
AL
F
ERVEVVRG
A
T
G
L
M
T
G
TG
NP
SA
AINMV
R
K
H
AT
SRE
------------
FKGDVSAEYGS
W
NK
ER
Y
VA
D
L
Q
SP
L
TE
DG
KIR
ARIVG
GY
QN
N
D
S
W
LDRYN
SE
K
TF
------
FSG
IV
D
A
DL
G
DL
T
T
LSAG
YEY
Q
RIDVNS
P
T
WGG
----
LP
RW
N
T
D
-----
GS
S
N
SYDR
AR
ST
AP
D
WAY
ND
K
EI
N
--------
K
V
FM
TLK
Q
R
FADTWQAT
L
N
AT
HSE
V
EFD
SKMMY
V
D
AY
VNKADGMLVGPYSNYGPGF
DY
V
G
GTG
WN
S
G
---------------------------
-
-
K
R
K
VDA
-------
--
-
--
-
-
---
-
L
D
LF
A
DG
SY
EL
FGR
QH
N
LMFGG
----------
SYSK
QN
N
RYFSSWANIFPD
EI
GSF
Y
N
FN
GN
F
P
QT
D
-
-
--
W
SP
-------------
----
---
------------QS
L
A
QDD
T
TH
M
KS
L
YAA
T
RVT
L
A
D
PLHLI
LG
A
R
-------
Y
----
--
-TNW
R
--------------
VDTLTY
-----
SM
EK
N
HT
----
TP
YA
GLVF
D
I
N
DNWS
T
YASYT
S
I
FQP
---------
Q
N
-
DR
D
SS
G
KY
-
L
A
P
I
TGNNYE
-------
LGLK
SDWM
N
SR
LT
T
T
L
AIF
R
I
E
Q
D
NVA
Q
S
---
T
GT
P
I
PGSN
GE
T
AYKAVDGTV
SKGVE
F
ELN
---
GA
I
T
D
NWQL
TF
GA
T
R
Y
I
AE
DN
-------
E
G
N
A
VN
PNLP
-----
RTTVKMF
T
SY
R
L
P
VMP
E
---
LT
V
G
-----
GGV
N
W
QN
--
R
VY
TDT
VT
PY
G
-
TFR
A
EQ
GSYALVDLFTRY
Q
VTK
----
NF
SLQGNVNNLFDKTY
D
TN
VE
GSIVY
-
--
-
GAPR
N
F
SI
TGTYQF
fig|562.372.peg.562
Escherichia coli 1212A
M
L
ST
Q
F
NRDNQ
Y
QA
IT
KPS
L
LAGCI
A
LAL
L
P
S
A
A
F
A
A
P
ATE
ETVIV
EG
SA
T
---
AP
D
D
GEN
DY
S
V
T
ST
------
SAGTKMQM
T
QR
DIPQSVT
I
VS
Q
Q
R
ME
D
QQ
LQ
TL
G
EV
M
E
NT
L
G
I
---
-
-
S
K
S
Q
A
D
S
D
R
A
LYY
SRGF
------
QI
DNYM
--
V
DGI
P
T
YFESR
WNLGDA
LS
DM
-
AL
F
ERVEVVRG
A
T
G
L
M
T
G
TG
NP
SA
AINMV
R
K
H
AT
SRE
------------
FKGDVSAEYGS
W
NK
ER
Y
VA
D
L
Q
SP
L
TE
DG
KIR
ARIVG
GY
QN
N
D
S
W
LDRYN
SE
K
TF
------
FSG
IV
D
A
DL
G
DL
T
T
LSAG
YEY
Q
RIDVNS
P
T
WGG
----
LP
RW
N
T
D
-----
GS
S
N
SYDR
AR
ST
AP
D
WAY
ND
K
EI
N
--------
K
V
FM
TLK
Q
R
FADTWQAT
L
N
AT
HSE
V
EFD
SKMMY
V
D
AY
VNKADGMLVGPYSNYGPGF
DY
V
G
GTG
WN
S
G
---------------------------
-
-
K
R
K
VDA
-------
--
-
--
-
-
---
-
L
D
LF
A
DG
SY
EL
FGR
QH
N
LMFGG
----------
SYSK
QN
N
RYFSSWANIFPD
EI
GSF
Y
N
FN
GN
F
P
QT
D
-
-
--
W
SP
-------------
----
---
------------QS
L
A
QDD
T
TH
M
KS
L
YAA
T
RVT
L
A
D
PLHLI
LG
A
R
-------
Y
----
--
-TNW
R
--------------
VDTLTY
-----
SM
EK
N
HT
----
TP
YA
GLVF
D
I
N
DNWS
T
YASYT
S
I
FQP
---------
Q
N
-
DR
D
SS
G
KY
-
L
A
P
I
TGNNYE
-------
LGLK
SDWM
N
SR
LT
T
T
L
AIF
R
I
E
Q
D
NVA
Q
S
---
T
GT
P
I
PGSN
GE
T
AYKAVDGTV
SKGVE
F
ELN
---
GA
I
T
D
NWQL
TF
GA
T
R
Y
I
AE
DN
-------
E
G
N
A
VN
PNLP
-----
RTTVKMF
T
SY
R
L
P
VMP
E
---
LT
V
G
-----
GGV
N
W
QN
--
R
VY
TDT
VT
PY
G
-
TFR
A
EQ
GSYALVDLFTRY
Q
VTK
----
NF
SLQGNVNNLFDKTY
D
TN
VE
GSIVY
-
--
-
GAPR
N
F
SI
TGTYQF
fig|562.374.peg.1605
Escherichia coli 536A
M
L
ST
Q
F
NRDNQ
Y
QA
IT
KPS
L
LAGCI
A
LAL
L
P
S
A
A
F
A
A
P
ATE
ETVIV
EG
SA
T
---
AP
D
D
GEN
DY
S
V
T
ST
------
SAGTKMQM
T
QR
DIPQSVT
I
VS
Q
Q
R
ME
D
QQ
LQ
TL
G
EV
M
E
NT
L
G
I
---
-
-
S
K
S
Q
A
D
S
D
R
A
LYY
SRGF
------
QI
DNYM
--
V
DGI
P
T
YFESR
WNLGDA
LS
DM
-
AL
F
ERVEVVRG
A
T
G
L
M
T
G
TG
NP
SA
AINMV
R
K
H
AT
SRE
------------
FKGDVSAEYGS
W
NK
ER
Y
VA
D
L
Q
SP
L
TE
DG
KIR
ARIVG
GY
QN
N
D
S
W
LDRYN
SE
K
TF
------
FSG
IV
D
A
DL
G
DL
T
T
LSAG
YEY
Q
RIDVNS
P
T
WGG
----
LP
RW
N
T
D
-----
GS
S
N
SYDR
AR
ST
AP
D
WAY
ND
K
EI
N
--------
K
V
FM
TLK
Q
R
FADTWQAT
L
N
AT
HSE
V
EFD
SKMMY
V
D
AY
VNKADGMLVGPYSNYGPGF
DY
V
G
GTG
WN
S
G
---------------------------
-
-
K
R
K
VDA
-------
--
-
--
-
-
---
-
L
D
LF
A
DG
SY
EL
FGR
QH
N
LMFGG
----------
SYSK
QN
N
RYFSSWANIFPD
EI
GSF
Y
N
FN
GN
F
P
QT
D
-
-
--
W
SP
-------------
----
---
------------QS
L
A
QDD
T
TH
M
KS
L
YAA
T
RVT
L
A
D
PLHLI
LG
A
R
-------
Y
----
--
-TNW
R
--------------
VDTLTY
-----
SM
EK
N
HT
----
TP
YA
GLVF
D
I
N
DNWS
T
YASYT
S
I
FQP
---------
Q
N
-
DR
D
SS
G
KY
-
L
A
P
I
TGNNYE
-------
LGLK
SDWM
N
SR
LT
T
T
L
AIF
R
I
E
Q
D
NVA
Q
S
---
T
GT
P
I
PGSN
GE
T
AYKAVDGTV
SKGVE
F
ELN
---
GA
I
T
D
NWQL
TF
GA
T
R
Y
I
AE
DN
-------
E
G
N
A
VN
PNLP
-----
RTTVKMF
T
SY
R
L
P
VMP
E
---
LT
V
G
-----
GGV
N
W
QN
--
R
VY
TDT
VT
PY
G
-
TFR
A
EQ
GSYALVDLFTRY
Q
VTK
----
NF
SLQGNVNNLFDKTY
D
TN
VE
GSIVY
-
--
-
GAPR
N
F
SI
TGTYQF
fig|344601.3.peg.4146
Escherichia coli B171
M
L
ST
Q
F
NRDNQ
Y
QA
IT
KPS
L
LAGCI
A
LAL
L
P
S
A
A
F
A
A
P
ATE
ETVIV
EG
SA
T
---
AP
D
D
GEN
DY
S
V
T
ST
------
SAGTKMQM
T
QR
DIPQSVT
I
VS
Q
Q
R
ME
D
QQ
LQ
TL
G
EV
M
E
NT
L
G
I
---
-
-
S
K
S
Q
A
D
S
D
R
A
LYY
SRGF
------
QI
DNYM
--
V
DGI
P
T
YFESR
WNLGDA
LS
DM
-
AL
F
ERVEVVRG
A
T
G
L
M
T
G
TG
NP
SA
AINMV
R
K
H
AT
SRE
------------
FKGDVSAEYGS
W
NK
ER
Y
VA
D
L
Q
SP
L
TE
DG
KIR
ARIVG
GY
QN
N
D
S
W
LDRYN
SE
K
TF
------
FSG
IV
D
A
DL
G
DL
T
T
LSAG
YEY
Q
RIDVNS
P
T
WGG
----
LP
RW
N
T
D
-----
GS
S
N
SYDR
AR
ST
AP
D
WAY
ND
K
EI
N
--------
K
V
FM
TLK
Q
R
FADTWQAT
L
N
AT
HSE
V
EFD
SKMMY
V
D
AY
VNKADGMLVGPYSNYGPGF
DY
V
G
GTG
WN
S
G
---------------------------
-
-
K
R
K
VDA
-------
--
-
--
-
-
---
-
L
D
LF
A
DG
SY
EL
FGR
QH
N
LMFGG
----------
SYSK
QN
N
RYFSSWANIFPD
EI
GSF
Y
N
FN
GN
F
P
QT
D
-
-
--
W
SP
-------------
----
---
------------QS
L
A
QDD
T
TH
M
KS
L
YAA
T
RVT
L
A
D
PLHLI
LG
A
R
-------
Y
----
--
-TNW
R
--------------
VDTLTY
-----
SM
EK
N
HT
----
TP
YA
GLVF
D
I
N
DNWS
T
YASYT
S
I
FQP
---------
Q
N
-
DR
D
SS
G
KY
-
L
A
P
I
TGNNYE
-------
LGLK
SDWM
N
SR
LT
T
T
L
AIF
R
I
E
Q
D
NVA
Q
S
---
T
GT
P
I
PGSN
GE
T
AYKAVDGTV
SKGVE
F
ELN
---
GA
I
T
D
NWQL
TF
GA
T
R
Y
I
AE
DN
-------
E
G
N
A
VN
PNLP
-----
RTTVKMF
T
SY
R
L
P
VMP
E
---
LT
V
G
-----
GGV
N
W
QN
--
R
VY
TDT
VT
PY
G
-
TFR
A
EQ
GSYALVDLFTRY
Q
VTK
----
NF
SLQGNVNNLFDKTY
D
TN
VE
GSIVY
-
--
-
GAPR
N
F
SI
TGTYQF
fig|344601.5.peg.4366
Escherichia coli B171
M
L
ST
Q
F
NRDNQ
Y
QA
IT
KPS
L
LAGCI
A
LAL
L
P
S
A
A
F
A
A
P
ATE
ETVIV
EG
SA
T
---
AP
D
D
GEN
DY
S
V
T
ST
------
SAGTKMQM
T
QR
DIPQSVT
I
VS
Q
Q
R
ME
D
QQ
LQ
TL
G
EV
M
E
NT
L
G
I
---
-
-
S
K
S
Q
A
D
S
D
R
A
LYY
SRGF
------
QI
DNYM
--
V
DGI
P
T
YFESR
WNLGDA
LS
DM
-
AL
F
ERVEVVRG
A
T
G
L
M
T
G
TG
NP
SA
AINMV
R
K
H
AT
SRE
------------
FKGDVSAEYGS
W
NK
ER
Y
VA
D
L
Q
SP
L
TE
DG
KIR
ARIVG
GY
QN
N
D
S
W
LDRYN
SE
K
TF
------
FSG
IV
D
A
DL
G
DL
T
T
LSAG
YEY
Q
RIDVNS
P
T
WGG
----
LP
RW
N
T
D
-----
GS
S
N
SYDR
AR
ST
AP
D
WAY
ND
K
EI
N
--------
K
V
FM
TLK
Q
R
FADTWQAT
L
N
AT
HSE
V
EFD
SKMMY
V
D
AY
VNKADGMLVGPYSNYGPGF
DY
V
G
GTG
WN
S
G
---------------------------
-
-
K
R
K
VDA
-------
--
-
--
-
-
---
-
L
D
LF
A
DG
SY
EL
FGR
QH
N
LMFGG
----------
SYSK
QN
N
RYFSSWANIFPD
EI
GSF
Y
N
FN
GN
F
P
QT
D
-
-
--
W
SP
-------------
----
---
------------QS
L
A
QDD
T
TH
M
KS
L
YAA
T
RVT
L
A
D
PLHLI
LG
A
R
-------
Y
----
--
-TNW
R
--------------
VDTLTY
-----
SM
EK
N
HT
----
TP
YA
GLVF
D
I
N
DNWS
T
YASYT
S
I
FQP
---------
Q
N
-
DR
D
SS
G
KY
-
L
A
P
I
TGNNYE
-------
LGLK
SDWM
N
SR
LT
T
T
L
AIF
R
I
E
Q
D
NVA
Q
S
---
T
GT
P
I
PGSN
GE
T
AYKAVDGTV
SKGVE
F
ELN
---
GA
I
T
D
NWQL
TF
GA
T
R
Y
I
AE
DN
-------
E
G
N
A
VN
PNLP
-----
RTTVKMF
T
SY
R
L
P
VMP
E
---
LT
V
G
-----
GGV
N
W
QN
--
R
VY
TDT
VT
PY
G
-
TFR
A
EQ
GSYALVDLFTRY
Q
VTK
----
NF
SLQGNVNNLFDKTY
D
TN
VE
GSIVY
-
--
-
GAPR
N
F
SI
TGTYQF
fig|550676.3.peg.599
Escherichia coli B185
M
L
ST
Q
F
NRDNQ
Y
QA
IT
KPS
L
LAGCI
A
LAL
L
P
S
A
A
F
A
A
P
ATE
ETVIV
EG
SA
T
---
AP
D
D
GEN
DY
S
V
T
ST
------
SAGTKMQM
T
QR
DIPQSVT
I
VS
Q
Q
R
ME
D
QQ
LQ
TL
G
EV
M
E
NT
L
G
I
---
-
-
S
K
S
Q
A
D
S
D
R
A
LYY
SRGF
------
QI
DNYM
--
V
DGI
P
T
YFESR
WNLGDA
LS
DM
-
AL
F
ERVEVVRG
A
T
G
L
M
T
G
TG
NP
SA
AINMV
R
K
H
AT
SRE
------------
FKGDVSAEYGS
W
NK
ER
Y
VA
D
L
Q
SP
L
TE
DG
KIR
ARIVG
GY
QN
N
D
S
W
LDRYN
SE
K
TF
------
FSG
IV
D
A
DL
G
DL
T
T
LSAG
YEY
Q
RIDVNS
P
T
WGG
----
LP
RW
N
T
D
-----
GS
S
N
SYDR
AR
ST
AP
D
WAY
ND
K
EI
N
--------
K
V
FM
TLK
Q
R
FADTWQAT
L
N
AT
HSE
V
EFD
SKMMY
V
D
AY
VNKADGMLVGPYSNYGPGF
DY
V
G
GTG
WN
S
G
---------------------------
-
-
K
R
K
VDA
-------
--
-
--
-
-
---
-
L
D
LF
A
DG
SY
EL
FGR
QH
N
LMFGG
----------
SYSK
QN
N
RYFSSWANIFPD
EI
GSF
Y
N
FN
GN
F
P
QT
D
-
-
--
W
SP
-------------
----
---
------------QS
L
A
QDD
T
TH
M
KS
L
YAA
T
RVT
L
A
D
PLHLI
LG
A
R
-------
Y
----
--
-TNW
R
--------------
VDTLTY
-----
SM
EK
N
HT
----
TP
YA
GLVF
D
I
N
DNWS
T
YASYT
S
I
FQP
---------
Q
N
-
DR
D
SS
G
KY
-
L
A
P
I
TGNNYE
-------
LGLK
SDWM
N
SR
LT
T
T
L
AIF
R
I
E
Q
D
NVA
Q
S
---
T
GT
P
I
PGSN
GE
T
AYKAVDGTV
SKGVE
F
ELN
---
GA
I
T
D
NWQL
TF
GA
T
R
Y
I
AE
DN
-------
E
G
N
A
VN
PNLP
-----
RTTVKMF
T
SY
R
L
P
VMP
E
---
LT
V
G
-----
GGV
N
W
QN
--
R
VY
TDT
VT
PY
G
-
TFR
A
EQ
GSYALVDLFTRY
Q
VTK
----
NF
SLQGNVNNLFDKTY
D
TN
VE
GSIVY
-
--
-
GAPR
N
F
SI
TGTYQF
fig|340185.3.peg.4642
Escherichia coli E22
M
L
ST
Q
F
NRDNQ
Y
QA
IT
KPS
L
LAGCI
A
LAL
L
P
S
A
A
F
A
A
P
ATE
ETVIV
EG
SA
T
---
AP
D
D
GEN
DY
S
V
T
ST
------
SAGTKMQM
T
QR
DIPQSVT
I
VS
Q
Q
R
ME
D
QQ
LQ
TL
G
EV
M
E
NT
L
G
I
---
-
-
S
K
S
Q
A
D
S
D
R
A
LYY
SRGF
------
QI
DNYM
--
V
DGI
P
T
YFESR
WNLGDA
LS
DM
-
AL
F
ERVEVVRG
A
T
G
L
M
T
G
TG
NP
SA
AINMV
R
K
H
AT
SRE
------------
FKGDVSAEYGS
W
NK
ER
Y
VA
D
L
Q
SP
L
TE
DG
KIR
ARIVG
GY
QN
N
D
S
W
LDRYN
SE
K
TF
------
FSG
IV
D
A
DL
G
DL
T
T
LSAG
YEY
Q
RIDVNS
P
T
WGG
----
LP
RW
N
T
D
-----
GS
S
N
SYDR
AR
ST
AP
D
WAY
ND
K
EI
N
--------
K
V
FM
TLK
Q
R
FADTWQAT
L
N
AT
HSE
V
EFD
SKMMY
V
D
AY
VNKADGMLVGPYSNYGPGF
DY
V
G
GTG
WN
S
G
---------------------------
-
-
K
R
K
VDA
-------
--
-
--
-
-
---
-
L
D
LF
A
DG
SY
EL
FGR
QH
N
LMFGG
----------
SYSK
QN
N
RYFSSWANIFPD
EI
GSF
Y
N
FN
GN
F
P
QT
D
-
-
--
W
SP
-------------
----
---
------------QS
L
A
QDD
T
TH
M
KS
L
YAA
T
RVT
L
A
D
PLHLI
LG
A
R
-------
Y
----
--
-TNW
R
--------------
VDTLTY
-----
SM
EK
N
HT
----
TP
YA
GLVF
D
I
N
DNWS
T
YASYT
S
I
FQP
---------
Q
N
-
DR
D
SS
G
KY
-
L
A
P
I
TGNNYE
-------
LGLK
SDWM
N
SR
LT
T
T
L
AIF
R
I
E
Q
D
NVA
Q
S
---
T
GT
P
I
PGSN
GE
T
AYKAVDGTV
SKGVE
F
ELN
---
GA
I
T
D
NWQL
TF
GA
T
R
Y
I
AE
DN
-------
E
G
N
A
VN
PNLP
-----
RTTVKMF
T
SY
R
L
P
VMP
E
---
LT
V
G
-----
GGV
N
W
QN
--
R
VY
TDT
VT
PY
G
-
TFR
A
EQ
GSYALVDLFTRY
Q
VTK
----
NF
SLQGNVNNLFDKTY
D
TN
VE
GSIVY
-
--
-
GAPR
N
F
SI
TGTYQF
fig|340185.4.peg.4902
Escherichia coli E22
M
L
ST
Q
F
NRDNQ
Y
QA
IT
KPS
L
LAGCI
A
LAL
L
P
S
A
A
F
A
A
P
ATE
ETVIV
EG
SA
T
---
AP
D
D
GEN
DY
S
V
T
ST
------
SAGTKMQM
T
QR
DIPQSVT
I
VS
Q
Q
R
ME
D
QQ
LQ
TL
G
EV
M
E
NT
L
G
I
---
-
-
S
K
S
Q
A
D
S
D
R
A
LYY
SRGF
------
QI
DNYM
--
V
DGI
P
T
YFESR
WNLGDA
LS
DM
-
AL
F
ERVEVVRG
A
T
G
L
M
T
G
TG
NP
SA
AINMV
R
K
H
AT
SRE
------------
FKGDVSAEYGS
W
NK
ER
Y
VA
D
L
Q
SP
L
TE
DG
KIR
ARIVG
GY
QN
N
D
S
W
LDRYN
SE
K
TF
------
FSG
IV
D
A
DL
G
DL
T
T
LSAG
YEY
Q
RIDVNS
P
T
WGG
----
LP
RW
N
T
D
-----
GS
S
N
SYDR
AR
ST
AP
D
WAY
ND
K
EI
N
--------
K
V
FM
TLK
Q
R
FADTWQAT
L
N
AT
HSE
V
EFD
SKMMY
V
D
AY
VNKADGMLVGPYSNYGPGF
DY
V
G
GTG
WN
S
G
---------------------------
-
-
K
R
K
VDA
-------
--
-
--
-
-
---
-
L
D
LF
A
DG
SY
EL
FGR
QH
N
LMFGG
----------
SYSK
QN
N
RYFSSWANIFPD
EI
GSF
Y
N
FN
GN
F
P
QT
D
-
-
--
W
SP
-------------
----
---
------------QS
L
A
QDD
T
TH
M
KS
L
YAA
T
RVT
L
A
D
PLHLI
LG
A
R
-------
Y
----
--
-TNW
R
--------------
VDTLTY
-----
SM
EK
N
HT
----
TP
YA
GLVF
D
I
N
DNWS
T
YASYT
S
I
FQP
---------
Q
N
-
DR
D
SS
G
KY
-
L
A
P
I
TGNNYE
-------
LGLK
SDWM
N
SR
LT
T
T
L
AIF
R
I
E
Q
D
NVA
Q
S
---
T
GT
P
I
PGSN
GE
T
AYKAVDGTV
SKGVE
F
ELN
---
GA
I
T
D
NWQL
TF
GA
T
R
Y
I
AE
DN
-------
E
G
N
A
VN
PNLP
-----
RTTVKMF
T
SY
R
L
P
VMP
E
---
LT
V
G
-----
GGV
N
W
QN
--
R
VY
TDT
VT
PY
G
-
TFR
A
EQ
GSYALVDLFTRY
Q
VTK
----
NF
SLQGNVNNLFDKTY
D
TN
VE
GSIVY
-
--
-
GAPR
N
F
SI
TGTYQF
fig|331111.12.peg.1512
Escherichia coli E24377A
M
L
ST
Q
F
NRDNQ
Y
QA
IT
KPS
L
LAGCI
A
LAL
L
P
S
A
A
F
A
A
P
ATE
ETVIV
EG
SA
T
---
AP
D
D
GEN
DY
S
V
T
ST
------
SAGTKMQM
T
QR
DIPQSVT
I
VS
Q
Q
R
ME
D
QQ
LQ
TL
G
EV
M
E
NT
L
G
I
---
-
-
S
K
S
Q
A
D
S
D
R
A
LYY
SRGF
------
QI
DNYM
--
V
DGI
P
T
YFESR
WNLGDA
LS
DM
-
AL
F
ERVEVVRG
A
T
G
L
M
T
G
TG
NP
SA
AINMV
R
K
H
AT
SRE
------------
FKGDVSAEYGS
W
NK
ER
Y
VA
D
L
Q
SP
L
TE
DG
KIR
ARIVG
GY
QN
N
D
S
W
LDRYN
SE
K
TF
------
FSG
IV
D
A
DL
G
DL
T
T
LSAG
YEY
Q
RIDVNS
P
T
WGG
----
LP
RW
N
T
D
-----
GS
S
N
SYDR
AR
ST
AP
D
WAY
ND
K
EI
N
--------
K
V
FM
TLK
Q
R
FADTWQAT
L
N
AT
HSE
V
EFD
SKMMY
V
D
AY
VNKADGMLVGPYSNYGPGF
DY
V
G
GTG
WN
S
G
---------------------------
-
-
K
R
K
VDA
-------
--
-
--
-
-
---
-
L
D
LF
A
DG
SY
EL
FGR
QH
N
LMFGG
----------
SYSK
QN
N
RYFSSWANIFPD
EI
GSF
Y
N
FN
GN
F
P
QT
D
-
-
--
W
SP
-------------
----
---
------------QS
L
A
QDD
T
TH
M
KS
L
YAA
T
RVT
L
A
D
PLHLI
LG
A
R
-------
Y
----
--
-TNW
R
--------------
VDTLTY
-----
SM
EK
N
HT
----
TP
YA
GLVF
D
I
N
DNWS
T
YASYT
S
I
FQP
---------
Q
N
-
DR
D
SS
G
KY
-
L
A
P
I
TGNNYE
-------
LGLK
SDWM
N
SR
LT
T
T
L
AIF
R
I
E
Q
D
NVA
Q
S
---
T
GT
P
I
PGSN
GE
T
AYKAVDGTV
SKGVE
F
ELN
---
GA
I
T
D
NWQL
TF
GA
T
R
Y
I
AE
DN
-------
E
G
N
A
VN
PNLP
-----
RTTVKMF
T
SY
R
L
P
VMP
E
---
LT
V
G
-----
GGV
N
W
QN
--
R
VY
TDT
VT
PY
G
-
TFR
A
EQ
GSYALVDLFTRY
Q
VTK
----
NF
SLQGNVNNLFDKTY
D
TN
VE
GSIVY
-
--
-
GAPR
N
F
SI
TGTYQF
fig|331111.3.peg.3699
Escherichia coli E24377A
M
L
ST
Q
F
NRDNQ
Y
QA
IT
KPS
L
LAGCI
A
LAL
L
P
S
A
A
F
A
A
P
ATE
ETVIV
EG
SA
T
---
AP
D
D
GEN
DY
S
V
T
ST
------
SAGTKMQM
T
QR
DIPQSVT
I
VS
Q
Q
R
ME
D
QQ
LQ
TL
G
EV
M
E
NT
L
G
I
---
-
-
S
K
S
Q
A
D
S
D
R
A
LYY
SRGF
------
QI
DNYM
--
V
DGI
P
T
YFESR
WNLGDA
LS
DM
-
AL
F
ERVEVVRG
A
T
G
L
M
T
G
TG
NP
SA
AINMV
R
K
H
AT
SRE
------------
FKGDVSAEYGS
W
NK
ER
Y
VA
D
L
Q
SP
L
TE
DG
KIR
ARIVG
GY
QN
N
D
S
W
LDRYN
SE
K
TF
------
FSG
IV
D
A
DL
G
DL
T
T
LSAG
YEY
Q
RIDVNS
P
T
WGG
----
LP
RW
N
T
D
-----
GS
S
N
SYDR
AR
ST
AP
D
WAY
ND
K
EI
N
--------
K
V
FM
TLK
Q
R
FADTWQAT
L
N
AT
HSE
V
EFD
SKMMY
V
D
AY
VNKADGMLVGPYSNYGPGF
DY
V
G
GTG
WN
S
G
---------------------------
-
-
K
R
K
VDA
-------
--
-
--
-
-
---
-
L
D
LF
A
DG
SY
EL
FGR
QH
N
LMFGG
----------
SYSK
QN
N
RYFSSWANIFPD
EI
GSF
Y
N
FN
GN
F
P
QT
D
-
-
--
W
SP
-------------
----
---
------------QS
L
A
QDD
T
TH
M
KS
L
YAA
T
RVT
L
A
D
PLHLI
LG
A
R
-------
Y
----
--
-TNW
R
--------------
VDTLTY
-----
SM
EK
N
HT
----
TP
YA
GLVF
D
I
N
DNWS
T
YASYT
S
I
FQP
---------
Q
N
-
DR
D
SS
G
KY
-
L
A
P
I
TGNNYE
-------
LGLK
SDWM
N
SR
LT
T
T
L
AIF
R
I
E
Q
D
NVA
Q
S
---
T
GT
P
I
PGSN
GE
T
AYKAVDGTV
SKGVE
F
ELN
---
GA
I
T
D
NWQL
TF
GA
T
R
Y
I
AE
DN
-------
E
G
N
A
VN
PNLP
-----
RTTVKMF
T
SY
R
L
P
VMP
E
---
LT
V
G
-----
GGV
N
W
QN
--
R
VY
TDT
VT
PY
G
-
TFR
A
EQ
GSYALVDLFTRY
Q
VTK
----
NF
SLQGNVNNLFDKTY
D
TN
VE
GSIVY
-
--
-
GAPR
N
F
SI
TGTYQF
fig|656419.3.peg.1446
Escherichia coli M718
M
L
ST
Q
F
NRDNQ
Y
QA
IT
KPS
L
LAGCI
A
LAL
L
P
S
A
A
F
A
A
P
ATE
ETVIV
EG
SA
T
---
AP
D
D
GEN
DY
S
V
T
ST
------
SAGTKMQM
T
QR
DIPQSVT
I
VS
Q
Q
R
ME
D
QQ
LQ
TL
G
EV
M
E
NT
L
G
I
---
-
-
S
K
S
Q
A
D
S
D
R
A
LYY
SRGF
------
QI
DNYM
--
V
DGI
P
T
YFESR
WNLGDA
LS
DM
-
AL
F
ERVEVVRG
A
T
G
L
M
T
G
TG
NP
SA
AINMV
R
K
H
AT
SRE
------------
FKGDVSAEYGS
W
NK
ER
Y
VA
D
L
Q
SP
L
TE
DG
KIR
ARIVG
GY
QN
N
D
S
W
LDRYN
SE
K
TF
------
FSG
IV
D
A
DL
G
DL
T
T
LSAG
YEY
Q
RIDVNS
P
T
WGG
----
LP
RW
N
T
D
-----
GS
S
N
SYDR
AR
ST
AP
D
WAY
ND
K
EI
N
--------
K
V
FM
TLK
Q
R
FADTWQAT
L
N
AT
HSE
V
EFD
SKMMY
V
D
AY
VNKADGMLVGPYSNYGPGF
DY
V
G
GTG
WN
S
G
---------------------------
-
-
K
R
K
VDA
-------
--
-
--
-
-
---
-
L
D
LF
A
DG
SY
EL
FGR
QH
N
LMFGG
----------
SYSK
QN
N
RYFSSWANIFPD
EI
GSF
Y
N
FN
GN
F
P
QT
D
-
-
--
W
SP
-------------
----
---
------------QS
L
A
QDD
T
TH
M
KS
L
YAA
T
RVT
L
A
D
PLHLI
LG
A
R
-------
Y
----
--
-TNW
R
--------------
VDTLTY
-----
SM
EK
N
HT
----
TP
YA
GLVF
D
I
N
DNWS
T
YASYT
S
I
FQP
---------
Q
N
-
DR
D
SS
G
KY
-
L
A
P
I
TGNNYE
-------
LGLK
SDWM
N
SR
LT
T
T
L
AIF
R
I
E
Q
D
NVA
Q
S
---
T
GT
P
I
PGSN
GE
T
AYKAVDGTV
SKGVE
F
ELN
---
GA
I
T
D
NWQL
TF
GA
T
R
Y
I
AE
DN
-------
E
G
N
A
VN
PNLP
-----
RTTVKMF
T
SY
R
L
P
VMP
E
---
LT
V
G
-----
GGV
N
W
QN
--
R
VY
TDT
VT
PY
G
-
TFR
A
EQ
GSYALVDLFTRY
Q
VTK
----
NF
SLQGNVNNLFDKTY
D
TN
VE
GSIVY
-
--
-
GAPR
N
F
SI
TGTYQF
fig|585395.4.peg.1208
Escherichia coli O103:H2 str. 12009
M
L
ST
Q
F
NRDNQ
Y
QA
IT
KPS
L
LAGCI
A
LAL
L
P
S
A
A
F
A
A
P
ATE
ETVIV
EG
SA
T
---
AP
D
D
GEN
DY
S
V
T
ST
------
SAGTKMQM
T
QR
DIPQSVT
I
VS
Q
Q
R
ME
D
QQ
LQ
TL
G
EV
M
E
NT
L
G
I
---
-
-
S
K
S
Q
A
D
S
D
R
A
LYY
SRGF
------
QI
DNYM
--
V
DGI
P
T
YFESR
WNLGDA
LS
DM
-
AL
F
ERVEVVRG
A
T
G
L
M
T
G
TG
NP
SA
AINMV
R
K
H
AT
SRE
------------
FKGDVSAEYGS
W
NK
ER
Y
VA
D
L
Q
SP
L
TE
DG
KIR
ARIVG
GY
QN
N
D
S
W
LDRYN
SE
K
TF
------
FSG
IV
D
A
DL
G
DL
T
T
LSAG
YEY
Q
RIDVNS
P
T
WGG
----
LP
RW
N
T
D
-----
GS
S
N
SYDR
AR
ST
AP
D
WAY
ND
K
EI
N
--------
K
V
FM
TLK
Q
R
FADTWQAT
L
N
AT
HSE
V
EFD
SKMMY
V
D
AY
VNKADGMLVGPYSNYGPGF
DY
V
G
GTG
WN
S
G
---------------------------
-
-
K
R
K
VDA
-------
--
-
--
-
-
---
-
L
D
LF
A
DG
SY
EL
FGR
QH
N
LMFGG
----------
SYSK
QN
N
RYFSSWANIFPD
EI
GSF
Y
N
FN
GN
F
P
QT
D
-
-
--
W
SP
-------------
----
---
------------QS
L
A
QDD
T
TH
M
KS
L
YAA
T
RVT
L
A
D
PLHLI
LG
A
R
-------
Y
----
--
-TNW
R
--------------
VDTLTY
-----
SM
EK
N
HT
----
TP
YA
GLVF
D
I
N
DNWS
T
YASYT
S
I
FQP
---------
Q
N
-
DR
D
SS
G
KY
-
L
A
P
I
TGNNYE
-------
LGLK
SDWM
N
SR
LT
T
T
L
AIF
R
I
E
Q
D
NVA
Q
S
---
T
GT
P
I
PGSN
GE
T
AYKAVDGTV
SKGVE
F
ELN
---
GA
I
T
D
NWQL
TF
GA
T
R
Y
I
AE
DN
-------
E
G
N
A
VN
PNLP
-----
RTTVKMF
T
SY
R
L
P
VMP
E
---
LT
V
G
-----
GGV
N
W
QN
--
R
VY
TDT
VT
PY
G
-
TFR
A
EQ
GSYALVDLFTRY
Q
VTK
----
NF
SLQGNVNNLFDKTY
D
TN
VE
GSIVY
-
--
-
GAPR
N
F
SI
TGTYQF
fig|83334.1.peg.1528
Escherichia coli O157:H7
M
L
ST
Q
F
NRDNQ
Y
QA
IT
KPS
L
LAGCI
A
LAL
L
P
S
A
A
F
A
A
P
ATE
ETVIV
EG
SA
T
---
AP
D
D
GEN
DY
S
V
T
ST
------
SAGTKMQM
T
QR
DIPQSVT
I
VS
Q
Q
R
ME
D
QQ
LQ
TL
G
EV
M
E
NT
L
G
I
---
-
-
S
K
S
Q
A
D
S
D
R
A
LYY
SRGF
------
QI
DNYM
--
V
DGI
P
T
YFESR
WNLGDA
LS
DM
-
AL
F
ERVEVVRG
A
T
G
L
M
T
G
TG
NP
SA
AINMV
R
K
H
AT
SRE
------------
FKGDVSAEYGS
W
NK
ER
Y
VA
D
L
Q
SP
L
TE
DG
KIR
ARIVG
GY
QN
N
D
S
W
LDRYN
SE
K
TF
------
FSG
IV
D
A
DL
G
DL
T
T
LSAG
YEY
Q
RIDVNS
P
T
WGG
----
LP
RW
N
T
D
-----
GS
S
N
SYDR
AR
ST
AP
D
WAY
ND
K
EI
N
--------
K
V
FM
TLK
Q
R
FADTWQAT
L
N
AT
HSE
V
EFD
SKMMY
V
D
AY
VNKADGMLVGPYSNYGPGF
DY
V
G
GTG
WN
S
G
---------------------------
-
-
K
R
K
VDA
-------
--
-
--
-
-
---
-
L
D
LF
A
DG
SY
EL
FGR
QH
N
LMFGG
----------
SYSK
QN
N
RYFSSWANIFPD
EI
GSF
Y
N
FN
GN
F
P
QT
D
-
-
--
W
SP
-------------
----
---
------------QS
L
A
QDD
T
TH
M
KS
L
YAA
T
RVT
L
A
D
PLHLI
LG
A
R
-------
Y
----
--
-TNW
R
--------------
VDTLTY
-----
SM
EK
N
HT
----
TP
YA
GLVF
D
I
N
DNWS
T
YASYT
S
I
FQP
---------
Q
N
-
DR
D
SS
G
KY
-
L
A
P
I
TGNNYE
-------
LGLK
SDWM
N
SR
LT
T
T
L
AIF
R
I
E
Q
D
NVA
Q
S
---
T
GT
P
I
PGSN
GE
T
AYKAVDGTV
SKGVE
F
ELN
---
GA
I
T
D
NWQL
TF
GA
T
R
Y
I
AE
DN
-------
E
G
N
A
VN
PNLP
-----
RTTVKMF
T
SY
R
L
P
VMP
E
---
LT
V
G
-----
GGV
N
W
QN
--
R
VY
TDT
VT
PY
G
-
TFR
A
EQ
GSYALVDLFTRY
Q
VTK
----
NF
SLQGNVNNLFDKTY
D
TN
VE
GSIVY
-
--
-
GAPR
N
F
SI
TGTYQF
fig|444454.5.peg.5969
Escherichia coli O157:H7 str. EC4024
M
L
ST
Q
F
NRDNQ
Y
QA
IT
KPS
L
LAGCI
A
LAL
L
P
S
A
A
F
A
A
P
ATE
ETVIV
EG
SA
T
---
AP
D
D
GEN
DY
S
V
T
ST
------
SAGTKMQM
T
QR
DIPQSVT
I
VS
Q
Q
R
ME
D
QQ
LQ
TL
G
EV
M
E
NT
L
G
I
---
-
-
S
K
S
Q
A
D
S
D
R
A
LYY
SRGF
------
QI
DNYM
--
V
DGI
P
T
YFESR
WNLGDA
LS
DM
-
AL
F
ERVEVVRG
A
T
G
L
M
T
G
TG
NP
SA
AINMV
R
K
H
AT
SRE
------------
FKGDVSAEYGS
W
NK
ER
Y
VA
D
L
Q
SP
L
TE
DG
KIR
ARIVG
GY
QN
N
D
S
W
LDRYN
SE
K
TF
------
FSG
IV
D
A
DL
G
DL
T
T
LSAG
YEY
Q
RIDVNS
P
T
WGG
----
LP
RW
N
T
D
-----
GS
S
N
SYDR
AR
ST
AP
D
WAY
ND
K
EI
N
--------
K
V
FM
TLK
Q
R
FADTWQAT
L
N
AT
HSE
V
EFD
SKMMY
V
D
AY
VNKADGMLVGPYSNYGPGF
DY
V
G
GTG
WN
S
G
---------------------------
-
-
K
R
K
VDA
-------
--
-
--
-
-
---
-
L
D
LF
A
DG
SY
EL
FGR
QH
N
LMFGG
----------
SYSK
QN
N
RYFSSWANIFPD
EI
GSF
Y
N
FN
GN
F
P
QT
D
-
-
--
W
SP
-------------
----
---
------------QS
L
A
QDD
T
TH
M
KS
L
YAA
T
RVT
L
A
D
PLHLI
LG
A
R
-------
Y
----
--
-TNW
R
--------------
VDTLTY
-----
SM
EK
N
HT
----
TP
YA
GLVF
D
I
N
DNWS
T
YASYT
S
I
FQP
---------
Q
N
-
DR
D
SS
G
KY
-
L
A
P
I
TGNNYE
-------
LGLK
SDWM
N
SR
LT
T
T
L
AIF
R
I
E
Q
D
NVA
Q
S
---
T
GT
P
I
PGSN
GE
T
AYKAVDGTV
SKGVE
F
ELN
---
GA
I
T
D
NWQL
TF
GA
T
R
Y
I
AE
DN
-------
E
G
N
A
VN
PNLP
-----
RTTVKMF
T
SY
R
L
P
VMP
E
---
LT
V
G
-----
GGV
N
W
QN
--
R
VY
TDT
VT
PY
G
-
TFR
A
EQ
GSYALVDLFTRY
Q
VTK
----
NF
SLQGNVNNLFDKTY
D
TN
VE
GSIVY
-
--
-
GAPR
N
F
SI
TGTYQF
fig|444449.5.peg.4827
Escherichia coli O157:H7 str. EC4042
M
L
ST
Q
F
NRDNQ
Y
QA
IT
KPS
L
LAGCI
A
LAL
L
P
S
A
A
F
A
A
P
ATE
ETVIV
EG
SA
T
---
AP
D
D
GEN
DY
S
V
T
ST
------
SAGTKMQM
T
QR
DIPQSVT
I
VS
Q
Q
R
ME
D
QQ
LQ
TL
G
EV
M
E
NT
L
G
I
---
-
-
S
K
S
Q
A
D
S
D
R
A
LYY
SRGF
------
QI
DNYM
--
V
DGI
P
T
YFESR
WNLGDA
LS
DM
-
AL
F
ERVEVVRG
A
T
G
L
M
T
G
TG
NP
SA
AINMV
R
K
H
AT
SRE
------------
FKGDVSAEYGS
W
NK
ER
Y
VA
D
L
Q
SP
L
TE
DG
KIR
ARIVG
GY
QN
N
D
S
W
LDRYN
SE
K
TF
------
FSG
IV
D
A
DL
G
DL
T
T
LSAG
YEY
Q
RIDVNS
P
T
WGG
----
LP
RW
N
T
D
-----
GS
S
N
SYDR
AR
ST
AP
D
WAY
ND
K
EI
N
--------
K
V
FM
TLK
Q
R
FADTWQAT
L
N
AT
HSE
V
EFD
SKMMY
V
D
AY
VNKADGMLVGPYSNYGPGF
DY
V
G
GTG
WN
S
G
---------------------------
-
-
K
R
K
VDA
-------
--
-
--
-
-
---
-
L
D
LF
A
DG
SY
EL
FGR
QH
N
LMFGG
----------
SYSK
QN
N
RYFSSWANIFPD
EI
GSF
Y
N
FN
GN
F
P
QT
D
-
-
--
W
SP
-------------
----
---
------------QS
L
A
QDD
T
TH
M
KS
L
YAA
T
RVT
L
A
D
PLHLI
LG
A
R
-------
Y
----
--
-TNW
R
--------------
VDTLTY
-----
SM
EK
N
HT
----
TP
YA
GLVF
D
I
N
DNWS
T
YASYT
S
I
FQP
---------
Q
N
-
DR
D
SS
G
KY
-
L
A
P
I
TGNNYE
-------
LGLK
SDWM
N
SR
LT
T
T
L
AIF
R
I
E
Q
D
NVA
Q
S
---
T
GT
P
I
PGSN
GE
T
AYKAVDGTV
SKGVE
F
ELN
---
GA
I
T
D
NWQL
TF
GA
T
R
Y
I
AE
DN
-------
E
G
N
A
VN
PNLP
-----
RTTVKMF
T
SY
R
L
P
VMP
E
---
LT
V
G
-----
GGV
N
W
QN
--
R
VY
TDT
VT
PY
G
-
TFR
A
EQ
GSYALVDLFTRY
Q
VTK
----
NF
SLQGNVNNLFDKTY
D
TN
VE
GSIVY
-
--
-
GAPR
N
F
SI
TGTYQF
fig|444448.5.peg.4090
Escherichia coli O157:H7 str. EC4045
M
L
ST
Q
F
NRDNQ
Y
QA
IT
KPS
L
LAGCI
A
LAL
L
P
S
A
A
F
A
A
P
ATE
ETVIV
EG
SA
T
---
AP
D
D
GEN
DY
S
V
T
ST
------
SAGTKMQM
T
QR
DIPQSVT
I
VS
Q
Q
R
ME
D
QQ
LQ
TL
G
EV
M
E
NT
L
G
I
---
-
-
S
K
S
Q
A
D
S
D
R
A
LYY
SRGF
------
QI
DNYM
--
V
DGI
P
T
YFESR
WNLGDA
LS
DM
-
AL
F
ERVEVVRG
A
T
G
L
M
T
G
TG
NP
SA
AINMV
R
K
H
AT
SRE
------------
FKGDVSAEYGS
W
NK
ER
Y
VA
D
L
Q
SP
L
TE
DG
KIR
ARIVG
GY
QN
N
D
S
W
LDRYN
SE
K
TF
------
FSG
IV
D
A
DL
G
DL
T
T
LSAG
YEY
Q
RIDVNS
P
T
WGG
----
LP
RW
N
T
D
-----
GS
S
N
SYDR
AR
ST
AP
D
WAY
ND
K
EI
N
--------
K
V
FM
TLK
Q
R
FADTWQAT
L
N
AT
HSE
V
EFD
SKMMY
V
D
AY
VNKADGMLVGPYSNYGPGF
DY
V
G
GTG
WN
S
G
---------------------------
-
-
K
R
K
VDA
-------
--
-
--
-
-
---
-
L
D
LF
A
DG
SY
EL
FGR
QH
N
LMFGG
----------
SYSK
QN
N
RYFSSWANIFPD
EI
GSF
Y
N
FN
GN
F
P
QT
D
-
-
--
W
SP
-------------
----
---
------------QS
L
A
QDD
T
TH
M
KS
L
YAA
T
RVT
L
A
D
PLHLI
LG
A
R
-------
Y
----
--
-TNW
R
--------------
VDTLTY
-----
SM
EK
N
HT
----
TP
YA
GLVF
D
I
N
DNWS
T
YASYT
S
I
FQP
---------
Q
N
-
DR
D
SS
G
KY
-
L
A
P
I
TGNNYE
-------
LGLK
SDWM
N
SR
LT
T
T
L
AIF
R
I
E
Q
D
NVA
Q
S
---
T
GT
P
I
PGSN
GE
T
AYKAVDGTV
SKGVE
F
ELN
---
GA
I
T
D
NWQL
TF
GA
T
R
Y
I
AE
DN
-------
E
G
N
A
VN
PNLP
-----
RTTVKMF
T
SY
R
L
P
VMP
E
---
LT
V
G
-----
GGV
N
W
QN
--
R
VY
TDT
VT
PY
G
-
TFR
A
EQ
GSYALVDLFTRY
Q
VTK
----
NF
SLQGNVNNLFDKTY
D
TN
VE
GSIVY
-
--
-
GAPR
N
F
SI
TGTYQF
fig|444453.5.peg.4751
Escherichia coli O157:H7 str. EC4076
M
L
ST
Q
F
NRDNQ
Y
QA
IT
KPS
L
LAGCI
A
LAL
L
P
S
A
A
F
A
A
P
ATE
ETVIV
EG
SA
T
---
AP
D
D
GEN
DY
S
V
T
ST
------
SAGTKMQM
T
QR
DIPQSVT
I
VS
Q
Q
R
ME
D
QQ
LQ
TL
G
EV
M
E
NT
L
G
I
---
-
-
S
K
S
Q
A
D
S
D
R
A
LYY
SRGF
------
QI
DNYM
--
V
DGI
P
T
YFESR
WNLGDA
LS
DM
-
AL
F
ERVEVVRG
A
T
G
L
M
T
G
TG
NP
SA
AINMV
R
K
H
AT
SRE
------------
FKGDVSAEYGS
W
NK
ER
Y
VA
D
L
Q
SP
L
TE
DG
KIR
ARIVG
GY
QN
N
D
S
W
LDRYN
SE
K
TF
------
FSG
IV
D
A
DL
G
DL
T
T
LSAG
YEY
Q
RIDVNS
P
T
WGG
----
LP
RW
N
T
D
-----
GS
S
N
SYDR
AR
ST
AP
D
WAY
ND
K
EI
N
--------
K
V
FM
TLK
Q
R
FADTWQAT
L
N
AT
HSE
V
EFD
SKMMY
V
D
AY
VNKADGMLVGPYSNYGPGF
DY
V
G
GTG
WN
S
G
---------------------------
-
-
K
R
K
VDA
-------
--
-
--
-
-
---
-
L
D
LF
A
DG
SY
EL
FGR
QH
N
LMFGG
----------
SYSK
QN
N
RYFSSWANIFPD
EI
GSF
Y
N
FN
GN
F
P
QT
D
-
-
--
W
SP
-------------
----
---
------------QS
L
A
QDD
T
TH
M
KS
L
YAA
T
RVT
L
A
D
PLHLI
LG
A
R
-------
Y
----
--
-TNW
R
--------------
VDTLTY
-----
SM
EK
N
HT
----
TP
YA
GLVF
D
I
N
DNWS
T
YASYT
S
I
FQP
---------
Q
N
-
DR
D
SS
G
KY
-
L
A
P
I
TGNNYE
-------
LGLK
SDWM
N
SR
LT
T
T
L
AIF
R
I
E
Q
D
NVA
Q
S
---
T
GT
P
I
PGSN
GE
T
AYKAVDGTV
SKGVE
F
ELN
---
GA
I
T
D
NWQL
TF
GA
T
R
Y
I
AE
DN
-------
E
G
N
A
VN
PNLP
-----
RTTVKMF
T
SY
R
L
P
VMP
E
---
LT
V
G
-----
GGV
N
W
QN
--
R
VY
TDT
VT
PY
G
-
TFR
A
EQ
GSYALVDLFTRY
Q
VTK
----
NF
SLQGNVNNLFDKTY
D
TN
VE
GSIVY
-
--
-
GAPR
N
F
SI
TGTYQF
fig|444452.5.peg.4255
Escherichia coli O157:H7 str. EC4113
M
L
ST
Q
F
NRDNQ
Y
QA
IT
KPS
L
LAGCI
A
LAL
L
P
S
A
A
F
A
A
P
ATE
ETVIV
EG
SA
T
---
AP
D
D
GEN
DY
S
V
T
ST
------
SAGTKMQM
T
QR
DIPQSVT
I
VS
Q
Q
R
ME
D
QQ
LQ
TL
G
EV
M
E
NT
L
G
I
---
-
-
S
K
S
Q
A
D
S
D
R
A
LYY
SRGF
------
QI
DNYM
--
V
DGI
P
T
YFESR
WNLGDA
LS
DM
-
AL
F
ERVEVVRG
A
T
G
L
M
T
G
TG
NP
SA
AINMV
R
K
H
AT
SRE
------------
FKGDVSAEYGS
W
NK
ER
Y
VA
D
L
Q
SP
L
TE
DG
KIR
ARIVG
GY
QN
N
D
S
W
LDRYN
SE
K
TF
------
FSG
IV
D
A
DL
G
DL
T
T
LSAG
YEY
Q
RIDVNS
P
T
WGG
----
LP
RW
N
T
D
-----
GS
S
N
SYDR
AR
ST
AP
D
WAY
ND
K
EI
N
--------
K
V
FM
TLK
Q
R
FADTWQAT
L
N
AT
HSE
V
EFD
SKMMY
V
D
AY
VNKADGMLVGPYSNYGPGF
DY
V
G
GTG
WN
S
G
---------------------------
-
-
K
R
K
VDA
-------
--
-
--
-
-
---
-
L
D
LF
A
DG
SY
EL
FGR
QH
N
LMFGG
----------
SYSK
QN
N
RYFSSWANIFPD
EI
GSF
Y
N
FN
GN
F
P
QT
D
-
-
--
W
SP
-------------
----
---
------------QS
L
A
QDD
T
TH
M
KS
L
YAA
T
RVT
L
A
D
PLHLI
LG
A
R
-------
Y
----
--
-TNW
R
--------------
VDTLTY
-----
SM
EK
N
HT
----
TP
YA
GLVF
D
I
N
DNWS
T
YASYT
S
I
FQP
---------
Q
N
-
DR
D
SS
G
KY
-
L
A
P
I
TGNNYE
-------
LGLK
SDWM
N
SR
LT
T
T
L
AIF
R
I
E
Q
D
NVA
Q
S
---
T
GT
P
I
PGSN
GE
T
AYKAVDGTV
SKGVE
F
ELN
---
GA
I
T
D
NWQL
TF
GA
T
R
Y
I
AE
DN
-------
E
G
N
A
VN
PNLP
-----
RTTVKMF
T
SY
R
L
P
VMP
E
---
LT
V
G
-----
GGV
N
W
QN
--
R
VY
TDT
VT
PY
G
-
TFR
A
EQ
GSYALVDLFTRY
Q
VTK
----
NF
SLQGNVNNLFDKTY
D
TN
VE
GSIVY
-
--
-
GAPR
N
F
SI
TGTYQF
fig|444450.8.peg.1551
Escherichia coli O157:H7 str. EC4115
M
L
ST
Q
F
NRDNQ
Y
QA
IT
KPS
L
LAGCI
A
LAL
L
P
S
A
A
F
A
A
P
ATE
ETVIV
EG
SA
T
---
AP
D
D
GEN
DY
S
V
T
ST
------
SAGTKMQM
T
QR
DIPQSVT
I
VS
Q
Q
R
ME
D
QQ
LQ
TL
G
EV
M
E
NT
L
G
I
---
-
-
S
K
S
Q
A
D
S
D
R
A
LYY
SRGF
------
QI
DNYM
--
V
DGI
P
T
YFESR
WNLGDA
LS
DM
-
AL
F
ERVEVVRG
A
T
G
L
M
T
G
TG
NP
SA
AINMV
R
K
H
AT
SRE
------------
FKGDVSAEYGS
W
NK
ER
Y
VA
D
L
Q
SP
L
TE
DG
KIR
ARIVG
GY
QN
N
D
S
W
LDRYN
SE
K
TF
------
FSG
IV
D
A
DL
G
DL
T
T
LSAG
YEY
Q
RIDVNS
P
T
WGG
----
LP
RW
N
T
D
-----
GS
S
N
SYDR
AR
ST
AP
D
WAY
ND
K
EI
N
--------
K
V
FM
TLK
Q
R
FADTWQAT
L
N
AT
HSE
V
EFD
SKMMY
V
D
AY
VNKADGMLVGPYSNYGPGF
DY
V
G
GTG
WN
S
G
---------------------------
-
-
K
R
K
VDA
-------
--
-
--
-
-
---
-
L
D
LF
A
DG
SY
EL
FGR
QH
N
LMFGG
----------
SYSK
QN
N
RYFSSWANIFPD
EI
GSF
Y
N
FN
GN
F
P
QT
D
-
-
--
W
SP
-------------
----
---
------------QS
L
A
QDD
T
TH
M
KS
L
YAA
T
RVT
L
A
D
PLHLI
LG
A
R
-------
Y
----
--
-TNW
R
--------------
VDTLTY
-----
SM
EK
N
HT
----
TP
YA
GLVF
D
I
N
DNWS
T
YASYT
S
I
FQP
---------
Q
N
-
DR
D
SS
G
KY
-
L
A
P
I
TGNNYE
-------
LGLK
SDWM
N
SR
LT
T
T
L
AIF
R
I
E
Q
D
NVA
Q
S
---
T
GT
P
I
PGSN
GE
T
AYKAVDGTV
SKGVE
F
ELN
---
GA
I
T
D
NWQL
TF
GA
T
R
Y
I
AE
DN
-------
E
G
N
A
VN
PNLP
-----
RTTVKMF
T
SY
R
L
P
VMP
E
---
LT
V
G
-----
GGV
N
W
QN
--
R
VY
TDT
VT
PY
G
-
TFR
A
EQ
GSYALVDLFTRY
Q
VTK
----
NF
SLQGNVNNLFDKTY
D
TN
VE
GSIVY
-
--
-
GAPR
N
F
SI
TGTYQF
fig|444451.5.peg.4288
Escherichia coli O157:H7 str. EC4196
M
L
ST
Q
F
NRDNQ
Y
QA
IT
KPS
L
LAGCI
A
LAL
L
P
S
A
A
F
A
A
P
ATE
ETVIV
EG
SA
T
---
AP
D
D
GEN
DY
S
V
T
ST
------
SAGTKMQM
T
QR
DIPQSVT
I
VS
Q
Q
R
ME
D
QQ
LQ
TL
G
EV
M
E
NT
L
G
I
---
-
-
S
K
S
Q
A
D
S
D
R
A
LYY
SRGF
------
QI
DNYM
--
V
DGI
P
T
YFESR
WNLGDA
LS
DM
-
AL
F
ERVEVVRG
A
T
G
L
M
T
G
TG
NP
SA
AINMV
R
K
H
AT
SRE
------------
FKGDVSAEYGS
W
NK
ER
Y
VA
D
L
Q
SP
L
TE
DG
KIR
ARIVG
GY
QN
N
D
S
W
LDRYN
SE
K
TF
------
FSG
IV
D
A
DL
G
DL
T
T
LSAG
YEY
Q
RIDVNS
P
T
WGG
----
LP
RW
N
T
D
-----
GS
S
N
SYDR
AR
ST
AP
D
WAY
ND
K
EI
N
--------
K
V
FM
TLK
Q
R
FADTWQAT
L
N
AT
HSE
V
EFD
SKMMY
V
D
AY
VNKADGMLVGPYSNYGPGF
DY
V
G
GTG
WN
S
G
---------------------------
-
-
K
R
K
VDA
-------
--
-
--
-
-
---
-
L
D
LF
A
DG
SY
EL
FGR
QH
N
LMFGG
----------
SYSK
QN
N
RYFSSWANIFPD
EI
GSF
Y
N
FN
GN
F
P
QT
D
-
-
--
W
SP
-------------
----
---
------------QS
L
A
QDD
T
TH
M
KS
L
YAA
T
RVT
L
A
D
PLHLI
LG
A
R
-------
Y
----
--
-TNW
R
--------------
VDTLTY
-----
SM
EK
N
HT
----
TP
YA
GLVF
D
I
N
DNWS
T
YASYT
S
I
FQP
---------
Q
N
-
DR
D
SS
G
KY
-
L
A
P
I
TGNNYE
-------
LGLK
SDWM
N
SR
LT
T
T
L
AIF
R
I
E
Q
D
NVA
Q
S
---
T
GT
P
I
PGSN
GE
T
AYKAVDGTV
SKGVE
F
ELN
---
GA
I
T
D
NWQL
TF
GA
T
R
Y
I
AE
DN
-------
E
G
N
A
VN
PNLP
-----
RTTVKMF
T
SY
R
L
P
VMP
E
---
LT
V
G
-----
GGV
N
W
QN
--
R
VY
TDT
VT
PY
G
-
TFR
A
EQ
GSYALVDLFTRY
Q
VTK
----
NF
SLQGNVNNLFDKTY
D
TN
VE
GSIVY
-
--
-
GAPR
N
F
SI
TGTYQF
fig|444447.5.peg.4329
Escherichia coli O157:H7 str. EC4206
M
L
ST
Q
F
NRDNQ
Y
QA
IT
KPS
L
LAGCI
A
LAL
L
P
S
A
A
F
A
A
P
ATE
ETVIV
EG
SA
T
---
AP
D
D
GEN
DY
S
V
T
ST
------
SAGTKMQM
T
QR
DIPQSVT
I
VS
Q
Q
R
ME
D
QQ
LQ
TL
G
EV
M
E
NT
L
G
I
---
-
-
S
K
S
Q
A
D
S
D
R
A
LYY
SRGF
------
QI
DNYM
--
V
DGI
P
T
YFESR
WNLGDA
LS
DM
-
AL
F
ERVEVVRG
A
T
G
L
M
T
G
TG
NP
SA
AINMV
R
K
H
AT
SRE
------------
FKGDVSAEYGS
W
NK
ER
Y
VA
D
L
Q
SP
L
TE
DG
KIR
ARIVG
GY
QN
N
D
S
W
LDRYN
SE
K
TF
------
FSG
IV
D
A
DL
G
DL
T
T
LSAG
YEY
Q
RIDVNS
P
T
WGG
----
LP
RW
N
T
D
-----
GS
S
N
SYDR
AR
ST
AP
D
WAY
ND
K
EI
N
--------
K
V
FM
TLK
Q
R
FADTWQAT
L
N
AT
HSE
V
EFD
SKMMY
V
D
AY
VNKADGMLVGPYSNYGPGF
DY
V
G
GTG
WN
S
G
---------------------------
-
-
K
R
K
VDA
-------
--
-
--
-
-
---
-
L
D
LF
A
DG
SY
EL
FGR
QH
N
LMFGG
----------
SYSK
QN
N
RYFSSWANIFPD
EI
GSF
Y
N
FN
GN
F
P
QT
D
-
-
--
W
SP
-------------
----
---
------------QS
L
A
QDD
T
TH
M
KS
L
YAA
T
RVT
L
A
D
PLHLI
LG
A
R
-------
Y
----
--
-TNW
R
--------------
VDTLTY
-----
SM
EK
N
HT
----
TP
YA
GLVF
D
I
N
DNWS
T
YASYT
S
I
FQP
---------
Q
N
-
DR
D
SS
G
KY
-
L
A
P
I
TGNNYE
-------
LGLK
SDWM
N
SR
LT
T
T
L
AIF
R
I
E
Q
D
NVA
Q
S
---
T
GT
P
I
PGSN
GE
T
AYKAVDGTV
SKGVE
F
ELN
---
GA
I
T
D
NWQL
TF
GA
T
R
Y
I
AE
DN
-------
E
G
N
A
VN
PNLP
-----
RTTVKMF
T
SY
R
L
P
VMP
E
---
LT
V
G
-----
GGV
N
W
QN
--
R
VY
TDT
VT
PY
G
-
TFR
A
EQ
GSYALVDLFTRY
Q
VTK
----
NF
SLQGNVNNLFDKTY
D
TN
VE
GSIVY
-
--
-
GAPR
N
F
SI
TGTYQF
fig|478004.5.peg.4429
Escherichia coli O157:H7 str. EC4401
M
L
ST
Q
F
NRDNQ
Y
QA
IT
KPS
L
LAGCI
A
LAL
L
P
S
A
A
F
A
A
P
ATE
ETVIV
EG
SA
T
---
AP
D
D
GEN
DY
S
V
T
ST
------
SAGTKMQM
T
QR
DIPQSVT
I
VS
Q
Q
R
ME
D
QQ
LQ
TL
G
EV
M
E
NT
L
G
I
---
-
-
S
K
S
Q
A
D
S
D
R
A
LYY
SRGF
------
QI
DNYM
--
V
DGI
P
T
YFESR
WNLGDA
LS
DM
-
AL
F
ERVEVVRG
A
T
G
L
M
T
G
TG
NP
SA
AINMV
R
K
H
AT
SRE
------------
FKGDVSAEYGS
W
NK
ER
Y
VA
D
L
Q
SP
L
TE
DG
KIR
ARIVG
GY
QN
N
D
S
W
LDRYN
SE
K
TF
------
FSG
IV
D
A
DL
G
DL
T
T
LSAG
YEY
Q
RIDVNS
P
T
WGG
----
LP
RW
N
T
D
-----
GS
S
N
SYDR
AR
ST
AP
D
WAY
ND
K
EI
N
--------
K
V
FM
TLK
Q
R
FADTWQAT
L
N
AT
HSE
V
EFD
SKMMY
V
D
AY
VNKADGMLVGPYSNYGPGF
DY
V
G
GTG
WN
S
G
---------------------------
-
-
K
R
K
VDA
-------
--
-
--
-
-
---
-
L
D
LF
A
DG
SY
EL
FGR
QH
N
LMFGG
----------
SYSK
QN
N
RYFSSWANIFPD
EI
GSF
Y
N
FN
GN
F
P
QT
D
-
-
--
W
SP
-------------
----
---
------------QS
L
A
QDD
T
TH
M
KS
L
YAA
T
RVT
L
A
D
PLHLI
LG
A
R
-------
Y
----
--
-TNW
R
--------------
VDTLTY
-----
SM
EK
N
HT
----
TP
YA
GLVF
D
I
N
DNWS
T
YASYT
S
I
FQP
---------
Q
N
-
DR
D
SS
G
KY
-
L
A
P
I
TGNNYE
-------
LGLK
SDWM
N
SR
LT
T
T
L
AIF
R
I
E
Q
D
NVA
Q
S
---
T
GT
P
I
PGSN
GE
T
AYKAVDGTV
SKGVE
F
ELN
---
GA
I
T
D
NWQL
TF
GA
T
R
Y
I
AE
DN
-------
E
G
N
A
VN
PNLP
-----
RTTVKMF
T
SY
R
L
P
VMP
E
---
LT
V
G
-----
GGV
N
W
QN
--
R
VY
TDT
VT
PY
G
-
TFR
A
EQ
GSYALVDLFTRY
Q
VTK
----
NF
SLQGNVNNLFDKTY
D
TN
VE
GSIVY
-
--
-
GAPR
N
F
SI
TGTYQF
fig|478006.5.peg.5174
Escherichia coli O157:H7 str. EC4501
M
L
ST
Q
F
NRDNQ
Y
QA
IT
KPS
L
LAGCI
A
LAL
L
P
S
A
A
F
A
A
P
ATE
ETVIV
EG
SA
T
---
AP
D
D
GEN
DY
S
V
T
ST
------
SAGTKMQM
T
QR
DIPQSVT
I
VS
Q
Q
R
ME
D
QQ
LQ
TL
G
EV
M
E
NT
L
G
I
---
-
-
S
K
S
Q
A
D
S
D
R
A
LYY
SRGF
------
QI
DNYM
--
V
DGI
P
T
YFESR
WNLGDA
LS
DM
-
AL
F
ERVEVVRG
A
T
G
L
M
T
G
TG
NP
SA
AINMV
R
K
H
AT
SRE
------------
FKGDVSAEYGS
W
NK
ER
Y
VA
D
L
Q
SP
L
TE
DG
KIR
ARIVG
GY
QN
N
D
S
W
LDRYN
SE
K
TF
------
FSG
IV
D
A
DL
G
DL
T
T
LSAG
YEY
Q
RIDVNS
P
T
WGG
----
LP
RW
N
T
D
-----
GS
S
N
SYDR
AR
ST
AP
D
WAY
ND
K
EI
N
--------
K
V
FM
TLK
Q
R
FADTWQAT
L
N
AT
HSE
V
EFD
SKMMY
V
D
AY
VNKADGMLVGPYSNYGPGF
DY
V
G
GTG
WN
S
G
---------------------------
-
-
K
R
K
VDA
-------
--
-
--
-
-
---
-
L
D
LF
A
DG
SY
EL
FGR
QH
N
LMFGG
----------
SYSK
QN
N
RYFSSWANIFPD
EI
GSF
Y
N
FN
GN
F
P
QT
D
-
-
--
W
SP
-------------
----
---
------------QS
L
A
QDD
T
TH
M
KS
L
YAA
T
RVT
L
A
D
PLHLI
LG
A
R
-------
Y
----
--
-TNW
R
--------------
VDTLTY
-----
SM
EK
N
HT
----
TP
YA
GLVF
D
I
N
DNWS
T
YASYT
S
I
FQP
---------
Q
N
-
DR
D
SS
G
KY
-
L
A
P
I
TGNNYE
-------
LGLK
SDWM
N
SR
LT
T
T
L
AIF
R
I
E
Q
D
NVA
Q
S
---
T
GT
P
I
PGSN
GE
T
AYKAVDGTV
SKGVE
F
ELN
---
GA
I
T
D
NWQL
TF
GA
T
R
Y
I
AE
DN
-------
E
G
N
A
VN
PNLP
-----
RTTVKMF
T
SY
R
L
P
VMP
E
---
LT
V
G
-----
GGV
N
W
QN
--
R
VY
TDT
VT
PY
G
-
TFR
A
EQ
GSYALVDLFTRY
Q
VTK
----
NF
SLQGNVNNLFDKTY
D
TN
VE
GSIVY
-
--
-
GAPR
N
F
SI
TGTYQF
fig|478007.5.peg.5093
Escherichia coli O157:H7 str. EC508
M
L
ST
Q
F
NRDNQ
Y
QA
IT
KPS
L
LAGCI
A
LAL
L
P
S
A
A
F
A
A
P
ATE
ETVIV
EG
SA
T
---
AP
D
D
GEN
DY
S
V
T
ST
------
SAGTKMQM
T
QR
DIPQSVT
I
VS
Q
Q
R
ME
D
QQ
LQ
TL
G
EV
M
E
NT
L
G
I
---
-
-
S
K
S
Q
A
D
S
D
R
A
LYY
SRGF
------
QI
DNYM
--
V
DGI
P
T
YFESR
WNLGDA
LS
DM
-
AL
F
ERVEVVRG
A
T
G
L
M
T
G
TG
NP
SA
AINMV
R
K
H
AT
SRE
------------
FKGDVSAEYGS
W
NK
ER
Y
VA
D
L
Q
SP
L
TE
DG
KIR
ARIVG
GY
QN
N
D
S
W
LDRYN
SE
K
TF
------
FSG
IV
D
A
DL
G
DL
T
T
LSAG
YEY
Q
RIDVNS
P
T
WGG
----
LP
RW
N
T
D
-----
GS
S
N
SYDR
AR
ST
AP
D
WAY
ND
K
EI
N
--------
K
V
FM
TLK
Q
R
FADTWQAT
L
N
AT
HSE
V
EFD
SKMMY
V
D
AY
VNKADGMLVGPYSNYGPGF
DY
V
G
GTG
WN
S
G
---------------------------
-
-
K
R
K
VDA
-------
--
-
--
-
-
---
-
L
D
LF
A
DG
SY
EL
FGR
QH
N
LMFGG
----------
SYSK
QN
N
RYFSSWANIFPD
EI
GSF
Y
N
FN
GN
F
P
QT
D
-
-
--
W
SP
-------------
----
---
------------QS
L
A
QDD
T
TH
M
KS
L
YAA
T
RVT
L
A
D
PLHLI
LG
A
R
-------
Y
----
--
-TNW
R
--------------
VDTLTY
-----
SM
EK
N
HT
----
TP
YA
GLVF
D
I
N
DNWS
T
YASYT
S
I
FQP
---------
Q
N
-
DR
D
SS
G
KY
-
L
A
P
I
TGNNYE
-------
LGLK
SDWM
N
SR
LT
T
T
L
AIF
R
I
E
Q
D
NVA
Q
S
---
T
GT
P
I
PGSN
GE
T
AYKAVDGTV
SKGVE
F
ELN
---
GA
I
T
D
NWQL
TF
GA
T
R
Y
I
AE
DN
-------
E
G
N
A
VN
PNLP
-----
RTTVKMF
T
SY
R
L
P
VMP
E
---
LT
V
G
-----
GGV
N
W
QN
--
R
VY
TDT
VT
PY
G
-
TFR
A
EQ
GSYALVDLFTRY
Q
VTK
----
NF
SLQGNVNNLFDKTY
D
TN
VE
GSIVY
-
--
-
GAPR
N
F
SI
TGTYQF
fig|478008.5.peg.5110
Escherichia coli O157:H7 str. EC869
M
L
ST
Q
F
NRDNQ
Y
QA
IT
KPS
L
LAGCI
A
LAL
L
P
S
A
A
F
A
A
P
ATE
ETVIV
EG
SA
T
---
AP
D
D
GEN
DY
S
V
T
ST
------
SAGTKMQM
T
QR
DIPQSVT
I
VS
Q
Q
R
ME
D
QQ
LQ
TL
G
EV
M
E
NT
L
G
I
---
-
-
S
K
S
Q
A
D
S
D
R
A
LYY
SRGF
------
QI
DNYM
--
V
DGI
P
T
YFESR
WNLGDA
LS
DM
-
AL
F
ERVEVVRG
A
T
G
L
M
T
G
TG
NP
SA
AINMV
R
K
H
AT
SRE
------------
FKGDVSAEYGS
W
NK
ER
Y
VA
D
L
Q
SP
L
TE
DG
KIR
ARIVG
GY
QN
N
D
S
W
LDRYN
SE
K
TF
------
FSG
IV
D
A
DL
G
DL
T
T
LSAG
YEY
Q
RIDVNS
P
T
WGG
----
LP
RW
N
T
D
-----
GS
S
N
SYDR
AR
ST
AP
D
WAY
ND
K
EI
N
--------
K
V
FM
TLK
Q
R
FADTWQAT
L
N
AT
HSE
V
EFD
SKMMY
V
D
AY
VNKADGMLVGPYSNYGPGF
DY
V
G
GTG
WN
S
G
---------------------------
-
-
K
R
K
VDA
-------
--
-
--
-
-
---
-
L
D
LF
A
DG
SY
EL
FGR
QH
N
LMFGG
----------
SYSK
QN
N
RYFSSWANIFPD
EI
GSF
Y
N
FN
GN
F
P
QT
D
-
-
--
W
SP
-------------
----
---
------------QS
L
A
QDD
T
TH
M
KS
L
YAA
T
RVT
L
A
D
PLHLI
LG
A
R
-------
Y
----
--
-TNW
R
--------------
VDTLTY
-----
SM
EK
N
HT
----
TP
YA
GLVF
D
I
N
DNWS
T
YASYT
S
I
FQP
---------
Q
N
-
DR
D
SS
G
KY
-
L
A
P
I
TGNNYE
-------
LGLK
SDWM
N
SR
LT
T
T
L
AIF
R
I
E
Q
D
NVA
Q
S
---
T
GT
P
I
PGSN
GE
T
AYKAVDGTV
SKGVE
F
ELN
---
GA
I
T
D
NWQL
TF
GA
T
R
Y
I
AE
DN
-------
E
G
N
A
VN
PNLP
-----
RTTVKMF
T
SY
R
L
P
VMP
E
---
LT
V
G
-----
GGV
N
W
QN
--
R
VY
TDT
VT
PY
G
-
TFR
A
EQ
GSYALVDLFTRY
Q
VTK
----
NF
SLQGNVNNLFDKTY
D
TN
VE
GSIVY
-
--
-
GAPR
N
F
SI
TGTYQF
fig|637388.3.peg.4079
Escherichia coli O157:H7 str. FRIK2000
M
L
ST
Q
F
NRDNQ
Y
QA
IT
KPS
L
LAGCI
A
LAL
L
P
S
A
A
F
A
A
P
ATE
ETVIV
EG
SA
T
---
AP
D
D
GEN
DY
S
V
T
ST
------
SAGTKMQM
T
QR
DIPQSVT
I
VS
Q
Q
R
ME
D
QQ
LQ
TL
G
EV
M
E
NT
L
G
I
---
-
-
S
K
S
Q
A
D
S
D
R
A
LYY
SRGF
------
QI
DNYM
--
V
DGI
P
T
YFESR
WNLGDA
LS
DM
-
AL
F
ERVEVVRG
A
T
G
L
M
T
G
TG
NP
SA
AINMV
R
K
H
AT
SRE
------------
FKGDVSAEYGS
W
NK
ER
Y
VA
D
L
Q
SP
L
TE
DG
KIR
ARIVG
GY
QN
N
D
S
W
LDRYN
SE
K
TF
------
FSG
IV
D
A
DL
G
DL
T
T
LSAG
YEY
Q
RIDVNS
P
T
WGG
----
LP
RW
N
T
D
-----
GS
S
N
SYDR
AR
ST
AP
D
WAY
ND
K
EI
N
--------
K
V
FM
TLK
Q
R
FADTWQAT
L
N
AT
HSE
V
EFD
SKMMY
V
D
AY
VNKADGMLVGPYSNYGPGF
DY
V
G
GTG
WN
S
G
---------------------------
-
-
K
R
K
VDA
-------
--
-
--
-
-
---
-
L
D
LF
A
DG
SY
EL
FGR
QH
N
LMFGG
----------
SYSK
QN
N
RYFSSWANIFPD
EI
GSF
Y
N
FN
GN
F
P
QT
D
-
-
--
W
SP
-------------
----
---
------------QS
L
A
QDD
T
TH
M
KS
L
YAA
T
RVT
L
A
D
PLHLI
LG
A
R
-------
Y
----
--
-TNW
R
--------------
VDTLTY
-----
SM
EK
N
HT
----
TP
YA
GLVF
D
I
N
DNWS
T
YASYT
S
I
FQP
---------
Q
N
-
DR
D
SS
G
KY
-
L
A
P
I
TGNNYE
-------
LGLK
SDWM
N
SR
LT
T
T
L
AIF
R
I
E
Q
D
NVA
Q
S
---
T
GT
P
I
PGSN
GE
T
AYKAVDGTV
SKGVE
F
ELN
---
GA
I
T
D
NWQL
TF
GA
T
R
Y
I
AE
DN
-------
E
G
N
A
VN
PNLP
-----
RTTVKMF
T
SY
R
L
P
VMP
E
---
LT
V
G
-----
GGV
N
W
QN
--
R
VY
TDT
VT
PY
G
-
TFR
A
EQ
GSYALVDLFTRY
Q
VTK
----
NF
SLQGNVNNLFDKTY
D
TN
VE
GSIVY
-
--
-
GAPR
N
F
SI
TGTYQF
fig|570506.3.peg.2082
Escherichia coli O157:H7 str. FRIK966
M
L
ST
Q
F
NRDNQ
Y
QA
IT
KPS
L
LAGCI
A
LAL
L
P
S
A
A
F
A
A
P
ATE
ETVIV
EG
SA
T
---
AP
D
D
GEN
DY
S
V
T
ST
------
SAGTKMQM
T
QR
DIPQSVT
I
VS
Q
Q
R
ME
D
QQ
LQ
TL
G
EV
M
E
NT
L
G
I
---
-
-
S
K
S
Q
A
D
S
D
R
A
LYY
SRGF
------
QI
DNYM
--
V
DGI
P
T
YFESR
WNLGDA
LS
DM
-
AL
F
ERVEVVRG
A
T
G
L
M
T
G
TG
NP
SA
AINMV
R
K
H
AT
SRE
------------
FKGDVSAEYGS
W
NK
ER
Y
VA
D
L
Q
SP
L
TE
DG
KIR
ARIVG
GY
QN
N
D
S
W
LDRYN
SE
K
TF
------
FSG
IV
D
A
DL
G
DL
T
T
LSAG
YEY
Q
RIDVNS
P
T
WGG
----
LP
RW
N
T
D
-----
GS
S
N
SYDR
AR
ST
AP
D
WAY
ND
K
EI
N
--------
K
V
FM
TLK
Q
R
FADTWQAT
L
N
AT
HSE
V
EFD
SKMMY
V
D
AY
VNKADGMLVGPYSNYGPGF
DY
V
G
GTG
WN
S
G
---------------------------
-
-
K
R
K
VDA
-------
--
-
--
-
-
---
-
L
D
LF
A
DG
SY
EL
FGR
QH
N
LMFGG
----------
SYSK
QN
N
RYFSSWANIFPD
EI
GSF
Y
N
FN
GN
F
P
QT
D
-
-
--
W
SP
-------------
----
---
------------QS
L
A
QDD
T
TH
M
KS
L
YAA
T
RVT
L
A
D
PLHLI
LG
A
R
-------
Y
----
--
-TNW
R
--------------
VDTLTY
-----
SM
EK
N
HT
----
TP
YA
GLVF
D
I
N
DNWS
T
YASYT
S
I
FQP
---------
Q
N
-
DR
D
SS
G
KY
-
L
A
P
I
TGNNYE
-------
LGLK
SDWM
N
SR
LT
T
T
L
AIF
R
I
E
Q
D
NVA
Q
S
---
T
GT
P
I
PGSN
GE
T
AYKAVDGTV
SKGVE
F
ELN
---
GA
I
T
D
NWQL
TF
GA
T
R
Y
I
AE
DN
-------
E
G
N
A
VN
PNLP
-----
RTTVKMF
T
SY
R
L
P
VMP
E
---
LT
V
G
-----
GGV
N
W
QN
--
R
VY
TDT
VT
PY
G
-
TFR
A
EQ
GSYALVDLFTRY
Q
VTK
----
NF
SLQGNVNNLFDKTY
D
TN
VE
GSIVY
-
--
-
GAPR
N
F
SI
TGTYQF
fig|386585.9.peg.1580
Escherichia coli O157:H7 str. Sakai
M
L
ST
Q
F
NRDNQ
Y
QA
IT
KPS
L
LAGCI
A
LAL
L
P
S
A
A
F
A
A
P
ATE
ETVIV
EG
SA
T
---
AP
D
D
GEN
DY
S
V
T
ST
------
SAGTKMQM
T
QR
DIPQSVT
I
VS
Q
Q
R
ME
D
QQ
LQ
TL
G
EV
M
E
NT
L
G
I
---
-
-
S
K
S
Q
A
D
S
D
R
A
LYY
SRGF
------
QI
DNYM
--
V
DGI
P
T
YFESR
WNLGDA
LS
DM
-
AL
F
ERVEVVRG
A
T
G
L
M
T
G
TG
NP
SA
AINMV
R
K
H
AT
SRE
------------
FKGDVSAEYGS
W
NK
ER
Y
VA
D
L
Q
SP
L
TE
DG
KIR
ARIVG
GY
QN
N
D
S
W
LDRYN
SE
K
TF
------
FSG
IV
D
A
DL
G
DL
T
T
LSAG
YEY
Q
RIDVNS
P
T
WGG
----
LP
RW
N
T
D
-----
GS
S
N
SYDR
AR
ST
AP
D
WAY
ND
K
EI
N
--------
K
V
FM
TLK
Q
R
FADTWQAT
L
N
AT
HSE
V
EFD
SKMMY
V
D
AY
VNKADGMLVGPYSNYGPGF
DY
V
G
GTG
WN
S
G
---------------------------
-
-
K
R
K
VDA
-------
--
-
--
-
-
---
-
L
D
LF
A
DG
SY
EL
FGR
QH
N
LMFGG
----------
SYSK
QN
N
RYFSSWANIFPD
EI
GSF
Y
N
FN
GN
F
P
QT
D
-
-
--
W
SP
-------------
----
---
------------QS
L
A
QDD
T
TH
M
KS
L
YAA
T
RVT
L
A
D
PLHLI
LG
A
R
-------
Y
----
--
-TNW
R
--------------
VDTLTY
-----
SM
EK
N
HT
----
TP
YA
GLVF
D
I
N
DNWS
T
YASYT
S
I
FQP
---------
Q
N
-
DR
D
SS
G
KY
-
L
A
P
I
TGNNYE
-------
LGLK
SDWM
N
SR
LT
T
T
L
AIF
R
I
E
Q
D
NVA
Q
S
---
T
GT
P
I
PGSN
GE
T
AYKAVDGTV
SKGVE
F
ELN
---
GA
I
T
D
NWQL
TF
GA
T
R
Y
I
AE
DN
-------
E
G
N
A
VN
PNLP
-----
RTTVKMF
T
SY
R
L
P
VMP
E
---
LT
V
G
-----
GGV
N
W
QN
--
R
VY
TDT
VT
PY
G
-
TFR
A
EQ
GSYALVDLFTRY
Q
VTK
----
NF
SLQGNVNNLFDKTY
D
TN
VE
GSIVY
-
--
-
GAPR
N
F
SI
TGTYQF
fig|544404.4.peg.1414
Escherichia coli O157:H7 str. TW14359
M
L
ST
Q
F
NRDNQ
Y
QA
IT
KPS
L
LAGCI
A
LAL
L
P
S
A
A
F
A
A
P
ATE
ETVIV
EG
SA
T
---
AP
D
D
GEN
DY
S
V
T
ST
------
SAGTKMQM
T
QR
DIPQSVT
I
VS
Q
Q
R
ME
D
QQ
LQ
TL
G
EV
M
E
NT
L
G
I
---
-
-
S
K
S
Q
A
D
S
D
R
A
LYY
SRGF
------
QI
DNYM
--
V
DGI
P
T
YFESR
WNLGDA
LS
DM
-
AL
F
ERVEVVRG
A
T
G
L
M
T
G
TG
NP
SA
AINMV
R
K
H
AT
SRE
------------
FKGDVSAEYGS
W
NK
ER
Y
VA
D
L
Q
SP
L
TE
DG
KIR
ARIVG
GY
QN
N
D
S
W
LDRYN
SE
K
TF
------
FSG
IV
D
A
DL
G
DL
T
T
LSAG
YEY
Q
RIDVNS
P
T
WGG
----
LP
RW
N
T
D
-----
GS
S
N
SYDR
AR
ST
AP
D
WAY
ND
K
EI
N
--------
K
V
FM
TLK
Q
R
FADTWQAT
L
N
AT
HSE
V
EFD
SKMMY
V
D
AY
VNKADGMLVGPYSNYGPGF
DY
V
G
GTG
WN
S
G
---------------------------
-
-
K
R
K
VDA
-------
--
-
--
-
-
---
-
L
D
LF
A
DG
SY
EL
FGR
QH
N
LMFGG
----------
SYSK
QN
N
RYFSSWANIFPD
EI
GSF
Y
N
FN
GN
F
P
QT
D
-
-
--
W
SP
-------------
----
---
------------QS
L
A
QDD
T
TH
M
KS
L
YAA
T
RVT
L
A
D
PLHLI
LG
A
R
-------
Y
----
--
-TNW
R
--------------
VDTLTY
-----
SM
EK
N
HT
----
TP
YA
GLVF
D
I
N
DNWS
T
YASYT
S
I
FQP
---------
Q
N
-
DR
D
SS
G
KY
-
L
A
P
I
TGNNYE
-------
LGLK
SDWM
N
SR
LT
T
T
L
AIF
R
I
E
Q
D
NVA
Q
S
---
T
GT
P
I
PGSN
GE
T
AYKAVDGTV
SKGVE
F
ELN
---
GA
I
T
D
NWQL
TF
GA
T
R
Y
I
AE
DN
-------
E
G
N
A
VN
PNLP
-----
RTTVKMF
T
SY
R
L
P
VMP
E
---
LT
V
G
-----
GGV
N
W
QN
--
R
VY
TDT
VT
PY
G
-
TFR
A
EQ
GSYALVDLFTRY
Q
VTK
----
NF
SLQGNVNNLFDKTY
D
TN
VE
GSIVY
-
--
-
GAPR
N
F
SI
TGTYQF
fig|502346.5.peg.2805
Escherichia coli O157:H7 str. TW14588
M
L
ST
Q
F
NRDNQ
Y
QA
IT
KPS
L
LAGCI
A
LAL
L
P
S
A
A
F
A
A
P
ATE
ETVIV
EG
SA
T
---
AP
D
D
GEN
DY
S
V
T
ST
------
SAGTKMQM
T
QR
DIPQSVT
I
VS
Q
Q
R
ME
D
QQ
LQ
TL
G
EV
M
E
NT
L
G
I
---
-
-
S
K
S
Q
A
D
S
D
R
A
LYY
SRGF
------
QI
DNYM
--
V
DGI
P
T
YFESR
WNLGDA
LS
DM
-
AL
F
ERVEVVRG
A
T
G
L
M
T
G
TG
NP
SA
AINMV
R
K
H
AT
SRE
------------
FKGDVSAEYGS
W
NK
ER
Y
VA
D
L
Q
SP
L
TE
DG
KIR
ARIVG
GY
QN
N
D
S
W
LDRYN
SE
K
TF
------
FSG
IV
D
A
DL
G
DL
T
T
LSAG
YEY
Q
RIDVNS
P
T
WGG
----
LP
RW
N
T
D
-----
GS
S
N
SYDR
AR
ST
AP
D
WAY
ND
K
EI
N
--------
K
V
FM
TLK
Q
R
FADTWQAT
L
N
AT
HSE
V
EFD
SKMMY
V
D
AY
VNKADGMLVGPYSNYGPGF
DY
V
G
GTG
WN
S
G
---------------------------
-
-
K
R
K
VDA
-------
--
-
--
-
-
---
-
L
D
LF
A
DG
SY
EL
FGR
QH
N
LMFGG
----------
SYSK
QN
N
RYFSSWANIFPD
EI
GSF
Y
N
FN
GN
F
P
QT
D
-
-
--
W
SP
-------------
----
---
------------QS
L
A
QDD
T
TH
M
KS
L
YAA
T
RVT
L
A
D
PLHLI
LG
A
R
-------
Y
----
--
-TNW
R
--------------
VDTLTY
-----
SM
EK
N
HT
----
TP
YA
GLVF
D
I
N
DNWS
T
YASYT
S
I
FQP
---------
Q
N
-
DR
D
SS
G
KY
-
L
A
P
I
TGNNYE
-------
LGLK
SDWM
N
SR
LT
T
T
L
AIF
R
I
E
Q
D
NVA
Q
S
---
T
GT
P
I
PGSN
GE
T
AYKAVDGTV
SKGVE
F
ELN
---
GA
I
T
D
NWQL
TF
GA
T
R
Y
I
AE
DN
-------
E
G
N
A
VN
PNLP
-----
RTTVKMF
T
SY
R
L
P
VMP
E
---
LT
V
G
-----
GGV
N
W
QN
--
R
VY
TDT
VT
PY
G
-
TFR
A
EQ
GSYALVDLFTRY
Q
VTK
----
NF
SLQGNVNNLFDKTY
D
TN
VE
GSIVY
-
--
-
GAPR
N
F
SI
TGTYQF
fig|595496.3.peg.1046
Escherichia coli BW2952
M
L
ST
Q
F
NRDNQ
Y
QA
IT
KPS
L
LAGCI
A
LAL
L
P
S
A
A
F
A
A
P
ATE
ETVIV
EG
SA
T
---
AP
D
D
GEN
DY
S
V
T
ST
------
SAGTKMQM
T
QR
DIPQSVT
I
VS
Q
Q
R
ME
D
QQ
LQ
TL
G
EV
M
E
NT
L
G
I
---
-
-
S
K
S
Q
A
D
S
D
R
A
LYY
SRGF
------
QI
DNYM
--
V
DGI
P
T
YFESR
WNLGDA
LS
DM
-
AL
F
ERVEVVRG
A
T
G
L
M
T
G
TG
NP
SA
AINMV
R
K
H
AT
SRE
------------
FKGDVSAEYGS
W
NK
ER
Y
VA
D
L
Q
SP
L
TE
DG
KIR
ARIVG
GY
QN
N
D
S
W
LDRYN
SE
K
TF
------
FSG
IV
D
A
DL
G
DL
T
T
LSAG
YEY
Q
RIDVNS
P
T
WGG
----
LP
RW
N
T
D
-----
GS
S
N
SYDR
AR
ST
AP
D
WAY
ND
K
EI
N
--------
K
V
FM
TLK
Q
Q
FADTWQAT
L
N
AT
HSE
V
EFD
SKMMY
V
D
AY
VNKADGMLVGPYSNYGPGF
DY
V
G
GTG
WN
S
G
---------------------------
-
-
K
R
K
VDA
-------
--
-
--
-
-
---
-
L
D
LF
A
DG
SY
EL
FGR
QH
N
LMFGG
----------
SYSK
QN
N
RYFSSWANIFPD
EI
GSF
Y
N
FN
GN
F
P
QT
D
-
-
--
W
SP
-------------
----
---
------------QS
L
A
QDD
T
TH
M
KS
L
YAA
T
RVT
L
A
D
PLHLI
LG
A
R
-------
Y
----
--
-TNW
R
--------------
VDTLTY
-----
SM
EK
N
HT
----
TP
YA
GLVF
D
I
N
DNWS
T
YASYT
S
I
FQP
---------
Q
N
-
DR
D
SS
G
KY
-
L
A
P
I
TGNNYE
-------
LGLK
SDWM
N
SR
LT
T
T
L
AIF
R
I
E
Q
D
NVA
Q
S
---
T
GT
P
I
PGSN
GE
T
AYKAVDGTV
SKGVE
F
ELN
---
GA
I
T
D
NWQL
TF
GA
T
R
Y
I
AE
DN
-------
E
G
N
A
VN
PNLP
-----
RTTVKMF
T
SY
R
L
P
VMP
E
---
LT
V
G
-----
GGV
N
W
QN
--
R
VY
TDT
VT
PY
G
-
TFR
A
EQ
GSYALVDLFTRY
Q
VTK
----
NF
SLQGNVNNLFDKTY
D
TN
VE
GSIVY
-
--
-
G
T
PR
N
F
SI
TGTYQF
fig|536056.3.peg.2680
Escherichia coli DH1
M
L
ST
Q
F
NRDNQ
Y
QA
IT
KPS
L
LAGCI
A
LAL
L
P
S
A
A
F
A
A
P
ATE
ETVIV
EG
SA
T
---
AP
D
D
GEN
DY
S
V
T
ST
------
SAGTKMQM
T
QR
DIPQSVT
I
VS
Q
Q
R
ME
D
QQ
LQ
TL
G
EV
M
E
NT
L
G
I
---
-
-
S
K
S
Q
A
D
S
D
R
A
LYY
SRGF
------
QI
DNYM
--
V
DGI
P
T
YFESR
WNLGDA
LS
DM
-
AL
F
ERVEVVRG
A
T
G
L
M
T
G
TG
NP
SA
AINMV
R
K
H
AT
SRE
------------
FKGDVSAEYGS
W
NK
ER
Y
VA
D
L
Q
SP
L
TE
DG
KIR
ARIVG
GY
QN
N
D
S
W
LDRYN
SE
K
TF
------
FSG
IV
D
A
DL
G
DL
T
T
LSAG
YEY
Q
RIDVNS
P
T
WGG
----
LP
RW
N
T
D
-----
GS
S
N
SYDR
AR
ST
AP
D
WAY
ND
K
EI
N
--------
K
V
FM
TLK
Q
Q
FADTWQAT
L
N
AT
HSE
V
EFD
SKMMY
V
D
AY
VNKADGMLVGPYSNYGPGF
DY
V
G
GTG
WN
S
G
---------------------------
-
-
K
R
K
VDA
-------
--
-
--
-
-
---
-
L
D
LF
A
DG
SY
EL
FGR
QH
N
LMFGG
----------
SYSK
QN
N
RYFSSWANIFPD
EI
GSF
Y
N
FN
GN
F
P
QT
D
-
-
--
W
SP
-------------
----
---
------------QS
L
A
QDD
T
TH
M
KS
L
YAA
T
RVT
L
A
D
PLHLI
LG
A
R
-------
Y
----
--
-TNW
R
--------------
VDTLTY
-----
SM
EK
N
HT
----
TP
YA
GLVF
D
I
N
DNWS
T
YASYT
S
I
FQP
---------
Q
N
-
DR
D
SS
G
KY
-
L
A
P
I
TGNNYE
-------
LGLK
SDWM
N
SR
LT
T
T
L
AIF
R
I
E
Q
D
NVA
Q
S
---
T
GT
P
I
PGSN
GE
T
AYKAVDGTV
SKGVE
F
ELN
---
GA
I
T
D
NWQL
TF
GA
T
R
Y
I
AE
DN
-------
E
G
N
A
VN
PNLP
-----
RTTVKMF
T
SY
R
L
P
VMP
E
---
LT
V
G
-----
GGV
N
W
QN
--
R
VY
TDT
VT
PY
G
-
TFR
A
EQ
GSYALVDLFTRY
Q
VTK
----
NF
SLQGNVNNLFDKTY
D
TN
VE
GSIVY
-
--
-
G
T
PR
N
F
SI
TGTYQF
fig|316401.4.peg.1346
Escherichia coli ETEC H10407
M
L
ST
Q
F
NRDNQ
Y
QA
IT
KPS
L
LAGCI
A
LAL
L
P
S
A
A
F
A
A
P
ATE
ETVIV
EG
SA
T
---
AP
D
D
GEN
DY
S
V
T
ST
------
SAGTKMQM
T
QR
DIPQSVT
I
VS
Q
Q
R
ME
D
QQ
LQ
TL
G
EV
M
E
NT
L
G
I
---
-
-
S
K
S
Q
A
D
S
D
R
A
LYY
SRGF
------
QI
DNYM
--
V
DGI
P
T
YFESR
WNLGDA
LS
DM
-
AL
F
ERVEVVRG
A
T
G
L
M
T
G
TG
NP
SA
AINMV
R
K
H
AT
SRE
------------
FKGDVSAEYGS
W
NK
ER
Y
VA
D
L
Q
SP
L
TE
DG
KIR
ARIVG
GY
QN
N
D
S
W
LDRYN
SE
K
TF
------
FSG
IV
D
A
DL
G
DL
T
T
LSAG
YEY
Q
RIDVNS
P
T
WGG
----
LP
RW
N
T
D
-----
GS
S
N
SYDR
AR
ST
AP
D
WAY
ND
K
EI
N
--------
K
V
FM
TLK
Q
Q
FADTWQAT
L
N
AT
HSE
V
EFD
SKMMY
V
D
AY
VNKADGMLVGPYSNYGPGF
DY
V
G
GTG
WN
S
G
---------------------------
-
-
K
R
K
VDA
-------
--
-
--
-
-
---
-
L
D
LF
A
DG
SY
EL
FGR
QH
N
LMFGG
----------
SYSK
QN
N
RYFSSWANIFPD
EI
GSF
Y
N
FN
GN
F
P
QT
D
-
-
--
W
SP
-------------
----
---
------------QS
L
A
QDD
T
TH
M
KS
L
YAA
T
RVT
L
A
D
PLHLI
LG
A
R
-------
Y
----
--
-TNW
R
--------------
VDTLTY
-----
SM
EK
N
HT
----
TP
YA
GLVF
D
I
N
DNWS
T
YASYT
S
I
FQP
---------
Q
N
-
DR
D
SS
G
KY
-
L
A
P
I
TGNNYE
-------
LGLK
SDWM
N
SR
LT
T
T
L
AIF
R
I
E
Q
D
NVA
Q
S
---
T
GT
P
I
PGSN
GE
T
AYKAVDGTV
SKGVE
F
ELN
---
GA
I
T
D
NWQL
TF
GA
T
R
Y
I
AE
DN
-------
E
G
N
A
VN
PNLP
-----
RTTVKMF
T
SY
R
L
P
VMP
E
---
LT
V
G
-----
GGV
N
W
QN
--
R
VY
TDT
VT
PY
G
-
TFR
A
EQ
GSYALVDLFTRY
Q
VTK
----
NF
SLQGNVNNLFDKTY
D
TN
VE
GSIVY
-
--
-
G
T
PR
N
F
SI
TGTYQF
fig|656414.3.peg.1344
Escherichia coli H736
M
L
ST
Q
F
NRDNQ
Y
QA
IT
KPS
L
LAGCI
A
LAL
L
P
S
A
A
F
A
A
P
ATE
ETVIV
EG
SA
T
---
AP
D
D
GEN
DY
S
V
T
ST
------
SAGTKMQM
T
QR
DIPQSVT
I
VS
Q
Q
R
ME
D
QQ
LQ
TL
G
EV
M
E
NT
L
G
I
---
-
-
S
K
S
Q
A
D
S
D
R
A
LYY
SRGF
------
QI
DNYM
--
V
DGI
P
T
YFESR
WNLGDA
LS
DM
-
AL
F
ERVEVVRG
A
T
G
L
M
T
G
TG
NP
SA
AINMV
R
K
H
AT
SRE
------------
FKGDVSAEYGS
W
NK
ER
Y
VA
D
L
Q
SP
L
TE
DG
KIR
ARIVG
GY
QN
N
D
S
W
LDRYN
SE
K
TF
------
FSG
IV
D
A
DL
G
DL
T
T
LSAG
YEY
Q
RIDVNS
P
T
WGG
----
LP
RW
N
T
D
-----
GS
S
N
SYDR
AR
ST
AP
D
WAY
ND
K
EI
N
--------
K
V
FM
TLK
Q
Q
FADTWQAT
L
N
AT
HSE
V
EFD
SKMMY
V
D
AY
VNKADGMLVGPYSNYGPGF
DY
V
G
GTG
WN
S
G
---------------------------
-
-
K
R
K
VDA
-------
--
-
--
-
-
---
-
L
D
LF
A
DG
SY
EL
FGR
QH
N
LMFGG
----------
SYSK
QN
N
RYFSSWANIFPD
EI
GSF
Y
N
FN
GN
F
P
QT
D
-
-
--
W
SP
-------------
----
---
------------QS
L
A
QDD
T
TH
M
KS
L
YAA
T
RVT
L
A
D
PLHLI
LG
A
R
-------
Y
----
--
-TNW
R
--------------
VDTLTY
-----
SM
EK
N
HT
----
TP
YA
GLVF
D
I
N
DNWS
T
YASYT
S
I
FQP
---------
Q
N
-
DR
D
SS
G
KY
-
L
A
P
I
TGNNYE
-------
LGLK
SDWM
N
SR
LT
T
T
L
AIF
R
I
E
Q
D
NVA
Q
S
---
T
GT
P
I
PGSN
GE
T
AYKAVDGTV
SKGVE
F
ELN
---
GA
I
T
D
NWQL
TF
GA
T
R
Y
I
AE
DN
-------
E
G
N
A
VN
PNLP
-----
RTTVKMF
T
SY
R
L
P
VMP
E
---
LT
V
G
-----
GGV
N
W
QN
--
R
VY
TDT
VT
PY
G
-
TFR
A
EQ
GSYALVDLFTRY
Q
VTK
----
NF
SLQGNVNNLFDKTY
D
TN
VE
GSIVY
-
--
-
G
T
PR
N
F
SI
TGTYQF
fig|83333.1.peg.1087
Escherichia coli K12
M
L
ST
Q
F
NRDNQ
Y
QA
IT
KPS
L
LAGCI
A
LAL
L
P
S
A
A
F
A
A
P
ATE
ETVIV
EG
SA
T
---
AP
D
D
GEN
DY
S
V
T
ST
------
SAGTKMQM
T
QR
DIPQSVT
I
VS
Q
Q
R
ME
D
QQ
LQ
TL
G
EV
M
E
NT
L
G
I
---
-
-
S
K
S
Q
A
D
S
D
R
A
LYY
SRGF
------
QI
DNYM
--
V
DGI
P
T
YFESR
WNLGDA
LS
DM
-
AL
F
ERVEVVRG
A
T
G
L
M
T
G
TG
NP
SA
AINMV
R
K
H
AT
SRE
------------
FKGDVSAEYGS
W
NK
ER
Y
VA
D
L
Q
SP
L
TE
DG
KIR
ARIVG
GY
QN
N
D
S
W
LDRYN
SE
K
TF
------
FSG
IV
D
A
DL
G
DL
T
T
LSAG
YEY
Q
RIDVNS
P
T
WGG
----
LP
RW
N
T
D
-----
GS
S
N
SYDR
AR
ST
AP
D
WAY
ND
K
EI
N
--------
K
V
FM
TLK
Q
Q
FADTWQAT
L
N
AT
HSE
V
EFD
SKMMY
V
D
AY
VNKADGMLVGPYSNYGPGF
DY
V
G
GTG
WN
S
G
---------------------------
-
-
K
R
K
VDA
-------
--
-
--
-
-
---
-
L
D
LF
A
DG
SY
EL
FGR
QH
N
LMFGG
----------
SYSK
QN
N
RYFSSWANIFPD
EI
GSF
Y
N
FN
GN
F
P
QT
D
-
-
--
W
SP
-------------
----
---
------------QS
L
A
QDD
T
TH
M
KS
L
YAA
T
RVT
L
A
D
PLHLI
LG
A
R
-------
Y
----
--
-TNW
R
--------------
VDTLTY
-----
SM
EK
N
HT
----
TP
YA
GLVF
D
I
N
DNWS
T
YASYT
S
I
FQP
---------
Q
N
-
DR
D
SS
G
KY
-
L
A
P
I
TGNNYE
-------
LGLK
SDWM
N
SR
LT
T
T
L
AIF
R
I
E
Q
D
NVA
Q
S
---
T
GT
P
I
PGSN
GE
T
AYKAVDGTV
SKGVE
F
ELN
---
GA
I
T
D
NWQL
TF
GA
T
R
Y
I
AE
DN
-------
E
G
N
A
VN
PNLP
-----
RTTVKMF
T
SY
R
L
P
VMP
E
---
LT
V
G
-----
GGV
N
W
QN
--
R
VY
TDT
VT
PY
G
-
TFR
A
EQ
GSYALVDLFTRY
Q
VTK
----
NF
SLQGNVNNLFDKTY
D
TN
VE
GSIVY
-
--
-
G
T
PR
N
F
SI
TGTYQF
fig|749538.3.peg.2092
Escherichia coli MS 116-1
M
L
ST
Q
F
NRDNQ
Y
QA
IT
KPS
L
LAGCI
A
LAL
L
P
S
A
A
F
A
A
P
ATE
ETVIV
EG
SA
T
---
AP
D
D
GEN
DY
S
V
T
ST
------
SAGTKMQM
T
QR
DIPQSVT
I
VS
Q
Q
R
ME
D
QQ
LQ
TL
G
EV
M
E
NT
L
G
I
---
-
-
S
K
S
Q
A
D
S
D
R
A
LYY
SRGF
------
QI
DNYM
--
V
DGI
P
T
YFESR
WNLGDA
LS
DM
-
AL
F
ERVEVVRG
A
T
G
L
M
T
G
TG
NP
SA
AINMV
R
K
H
AT
SRE
------------
FKGDVSAEYGS
W
NK
ER
Y
VA
D
L
Q
SP
L
TE
DG
KIR
ARIVG
GY
QN
N
D
S
W
LDRYN
SE
K
TF
------
FSG
IV
D
A
DL
G
DL
T
T
LSAG
YEY
Q
RIDVNS
P
T
WGG
----
LP
RW
N
T
D
-----
GS
S
N
SYDR
AR
ST
AP
D
WAY
ND
K
EI
N
--------
K
V
FM
TLK
Q
Q
FADTWQAT
L
N
AT
HSE
V
EFD
SKMMY
V
D
AY
VNKADGMLVGPYSNYGPGF
DY
V
G
GTG
WN
S
G
---------------------------
-
-
K
R
K
VDA
-------
--
-
--
-
-
---
-
L
D
LF
A
DG
SY
EL
FGR
QH
N
LMFGG
----------
SYSK
QN
N
RYFSSWANIFPD
EI
GSF
Y
N
FN
GN
F
P
QT
D
-
-
--
W
SP
-------------
----
---
------------QS
L
A
QDD
T
TH
M
KS
L
YAA
T
RVT
L
A
D
PLHLI
LG
A
R
-------
Y
----
--
-TNW
R
--------------
VDTLTY
-----
SM
EK
N
HT
----
TP
YA
GLVF
D
I
N
DNWS
T
YASYT
S
I
FQP
---------
Q
N
-
DR
D
SS
G
KY
-
L
A
P
I
TGNNYE
-------
LGLK
SDWM
N
SR
LT
T
T
L
AIF
R
I
E
Q
D
NVA
Q
S
---
T
GT
P
I
PGSN
GE
T
AYKAVDGTV
SKGVE
F
ELN
---
GA
I
T
D
NWQL
TF
GA
T
R
Y
I
AE
DN
-------
E
G
N
A
VN
PNLP
-----
RTTVKMF
T
SY
R
L
P
VMP
E
---
LT
V
G
-----
GGV
N
W
QN
--
R
VY
TDT
VT
PY
G
-
TFR
A
EQ
GSYALVDLFTRY
Q
VTK
----
NF
SLQGNVNNLFDKTY
D
TN
VE
GSIVY
-
--
-
G
T
PR
N
F
SI
TGTYQF
fig|749540.3.peg.1127
Escherichia coli MS 146-1
M
L
ST
Q
F
NRDNQ
Y
QA
IT
KPS
L
LAGCI
A
LAL
L
P
S
A
A
F
A
A
P
ATE
ETVIV
EG
SA
T
---
AP
D
D
GEN
DY
S
V
T
ST
------
SAGTKMQM
T
QR
DIPQSVT
I
VS
Q
Q
R
ME
D
QQ
LQ
TL
G
EV
M
E
NT
L
G
I
---
-
-
S
K
S
Q
A
D
S
D
R
A
LYY
SRGF
------
QI
DNYM
--
V
DGI
P
T
YFESR
WNLGDA
LS
DM
-
AL
F
ERVEVVRG
A
T
G
L
M
T
G
TG
NP
SA
AINMV
R
K
H
AT
SRE
------------
FKGDVSAEYGS
W
NK
ER
Y
VA
D
L
Q
SP
L
TE
DG
KIR
ARIVG
GY
QN
N
D
S
W
LDRYN
SE
K
TF
------
FSG
IV
D
A
DL
G
DL
T
T
LSAG
YEY
Q
RIDVNS
P
T
WGG
----
LP
RW
N
T
D
-----
GS
S
N
SYDR
AR
ST
AP
D
WAY
ND
K
EI
N
--------
K
V
FM
TLK
Q
Q
FADTWQAT
L
N
AT
HSE
V
EFD
SKMMY
V
D
AY
VNKADGMLVGPYSNYGPGF
DY
V
G
GTG
WN
S
G
---------------------------
-
-
K
R
K
VDA
-------
--
-
--
-
-
---
-
L
D
LF
A
DG
SY
EL
FGR
QH
N
LMFGG
----------
SYSK
QN
N
RYFSSWANIFPD
EI
GSF
Y
N
FN
GN
F
P
QT
D
-
-
--
W
SP
-------------
----
---
------------QS
L
A
QDD
T
TH
M
KS
L
YAA
T
RVT
L
A
D
PLHLI
LG
A
R
-------
Y
----
--
-TNW
R
--------------
VDTLTY
-----
SM
EK
N
HT
----
TP
YA
GLVF
D
I
N
DNWS
T
YASYT
S
I
FQP
---------
Q
N
-
DR
D
SS
G
KY
-
L
A
P
I
TGNNYE
-------
LGLK
SDWM
N
SR
LT
T
T
L
AIF
R
I
E
Q
D
NVA
Q
S
---
T
GT
P
I
PGSN
GE
T
AYKAVDGTV
SKGVE
F
ELN
---
GA
I
T
D
NWQL
TF
GA
T
R
Y
I
AE
DN
-------
E
G
N
A
VN
PNLP
-----
RTTVKMF
T
SY
R
L
P
VMP
E
---
LT
V
G
-----
GGV
N
W
QN
--
R
VY
TDT
VT
PY
G
-
TFR
A
EQ
GSYALVDLFTRY
Q
VTK
----
NF
SLQGNVNNLFDKTY
D
TN
VE
GSIVY
-
--
-
G
T
PR
N
F
SI
TGTYQF
fig|749548.3.peg.5050
Escherichia coli MS 196-1
M
L
ST
Q
F
NRDNQ
Y
QA
IT
KPS
L
LAGCI
A
LAL
L
P
S
A
A
F
A
A
P
ATE
ETVIV
EG
SA
T
---
AP
D
D
GEN
DY
S
V
T
ST
------
SAGTKMQM
T
QR
DIPQSVT
I
VS
Q
Q
R
ME
D
QQ
LQ
TL
G
EV
M
E
NT
L
G
I
---
-
-
S
K
S
Q
A
D
S
D
R
A
LYY
SRGF
------
QI
DNYM
--
V
DGI
P
T
YFESR
WNLGDA
LS
DM
-
AL
F
ERVEVVRG
A
T
G
L
M
T
G
TG
NP
SA
AINMV
R
K
H
AT
SRE
------------
FKGDVSAEYGS
W
NK
ER
Y
VA
D
L
Q
SP
L
TE
DG
KIR
ARIVG
GY
QN
N
D
S
W
LDRYN
SE
K
TF
------
FSG
IV
D
A
DL
G
DL
T
T
LSAG
YEY
Q
RIDVNS
P
T
WGG
----
LP
RW
N
T
D
-----
GS
S
N
SYDR
AR
ST
AP
D
WAY
ND
K
EI
N
--------
K
V
FM
TLK
Q
Q
FADTWQAT
L
N
AT
HSE
V
EFD
SKMMY
V
D
AY
VNKADGMLVGPYSNYGPGF
DY
V
G
GTG
WN
S
G
---------------------------
-
-
K
R
K
VDA
-------
--
-
--
-
-
---
-
L
D
LF
A
DG
SY
EL
FGR
QH
N
LMFGG
----------
SYSK
QN
N
RYFSSWANIFPD
EI
GSF
Y
N
FN
GN
F
P
QT
D
-
-
--
W
SP
-------------
----
---
------------QS
L
A
QDD
T
TH
M
KS
L
YAA
T
RVT
L
A
D
PLHLI
LG
A
R
-------
Y
----
--
-TNW
R
--------------
VDTLTY
-----
SM
EK
N
HT
----
TP
YA
GLVF
D
I
N
DNWS
T
YASYT
S
I
FQP
---------
Q
N
-
DR
D
SS
G
KY
-
L
A
P
I
TGNNYE
-------
LGLK
SDWM
N
SR
LT
T
T
L
AIF
R
I
E
Q
D
NVA
Q
S
---
T
GT
P
I
PGSN
GE
T
AYKAVDGTV
SKGVE
F
ELN
---
GA
I
T
D
NWQL
TF
GA
T
R
Y
I
AE
DN
-------
E
G
N
A
VN
PNLP
-----
RTTVKMF
T
SY
R
L
P
VMP
E
---
LT
V
G
-----
GGV
N
W
QN
--
R
VY
TDT
VT
PY
G
-
TFR
A
EQ
GSYALVDLFTRY
Q
VTK
----
NF
SLQGNVNNLFDKTY
D
TN
VE
GSIVY
-
--
-
G
T
PR
N
F
SI
TGTYQF
fig|316407.3.peg.1064
Escherichia coli W3110
M
L
ST
Q
F
NRDNQ
Y
QA
IT
KPS
L
LAGCI
A
LAL
L
P
S
A
A
F
A
A
P
ATE
ETVIV
EG
SA
T
---
AP
D
D
GEN
DY
S
V
T
ST
------
SAGTKMQM
T
QR
DIPQSVT
I
VS
Q
Q
R
ME
D
QQ
LQ
TL
G
EV
M
E
NT
L
G
I
---
-
-
S
K
S
Q
A
D
S
D
R
A
LYY
SRGF
------
QI
DNYM
--
V
DGI
P
T
YFESR
WNLGDA
LS
DM
-
AL
F
ERVEVVRG
A
T
G
L
M
T
G
TG
NP
SA
AINMV
R
K
H
AT
SRE
------------
FKGDVSAEYGS
W
NK
ER
Y
VA
D
L
Q
SP
L
TE
DG
KIR
ARIVG
GY
QN
N
D
S
W
LDRYN
SE
K
TF
------
FSG
IV
D
A
DL
G
DL
T
T
LSAG
YEY
Q
RIDVNS
P
T
WGG
----
LP
RW
N
T
D
-----
GS
S
N
SYDR
AR
ST
AP
D
WAY
ND
K
EI
N
--------
K
V
FM
TLK
Q
Q
FADTWQAT
L
N
AT
HSE
V
EFD
SKMMY
V
D
AY
VNKADGMLVGPYSNYGPGF
DY
V
G
GTG
WN
S
G
---------------------------
-
-
K
R
K
VDA
-------
--
-
--
-
-
---
-
L
D
LF
A
DG
SY
EL
FGR
QH
N
LMFGG
----------
SYSK
QN
N
RYFSSWANIFPD
EI
GSF
Y
N
FN
GN
F
P
QT
D
-
-
--
W
SP
-------------
----
---
------------QS
L
A
QDD
T
TH
M
KS
L
YAA
T
RVT
L
A
D
PLHLI
LG
A
R
-------
Y
----
--
-TNW
R
--------------
VDTLTY
-----
SM
EK
N
HT
----
TP
YA
GLVF
D
I
N
DNWS
T
YASYT
S
I
FQP
---------
Q
N
-
DR
D
SS
G
KY
-
L
A
P
I
TGNNYE
-------
LGLK
SDWM
N
SR
LT
T
T
L
AIF
R
I
E
Q
D
NVA
Q
S
---
T
GT
P
I
PGSN
GE
T
AYKAVDGTV
SKGVE
F
ELN
---
GA
I
T
D
NWQL
TF
GA
T
R
Y
I
AE
DN
-------
E
G
N
A
VN
PNLP
-----
RTTVKMF
T
SY
R
L
P
VMP
E
---
LT
V
G
-----
GGV
N
W
QN
--
R
VY
TDT
VT
PY
G
-
TFR
A
EQ
GSYALVDLFTRY
Q
VTK
----
NF
SLQGNVNNLFDKTY
D
TN
VE
GSIVY
-
--
-
G
T
PR
N
F
SI
TGTYQF
fig|316385.5.peg.1178
Escherichia coli str. K-12 substr. DH10B
M
L
ST
Q
F
NRDNQ
Y
QA
IT
KPS
L
LAGCI
A
LAL
L
P
S
A
A
F
A
A
P
ATE
ETVIV
EG
SA
T
---
AP
D
D
GEN
DY
S
V
T
ST
------
SAGTKMQM
T
QR
DIPQSVT
I
VS
Q
Q
R
ME
D
QQ
LQ
TL
G
EV
M
E
NT
L
G
I
---
-
-
S
K
S
Q
A
D
S
D
R
A
LYY
SRGF
------
QI
DNYM
--
V
DGI
P
T
YFESR
WNLGDA
LS
DM
-
AL
F
ERVEVVRG
A
T
G
L
M
T
G
TG
NP
SA
AINMV
R
K
H
AT
SRE
------------
FKGDVSAEYGS
W
NK
ER
Y
VA
D
L
Q
SP
L
TE
DG
KIR
ARIVG
GY
QN
N
D
S
W
LDRYN
SE
K
TF
------
FSG
IV
D
A
DL
G
DL
T
T
LSAG
YEY
Q
RIDVNS
P
T
WGG
----
LP
RW
N
T
D
-----
GS
S
N
SYDR
AR
ST
AP
D
WAY
ND
K
EI
N
--------
K
V
FM
TLK
Q
Q
FADTWQAT
L
N
AT
HSE
V
EFD
SKMMY
V
D
AY
VNKADGMLVGPYSNYGPGF
DY
V
G
GTG
WN
S
G
---------------------------
-
-
K
R
K
VDA
-------
--
-
--
-
-
---
-
L
D
LF
A
DG
SY
EL
FGR
QH
N
LMFGG
----------
SYSK
QN
N
RYFSSWANIFPD
EI
GSF
Y
N
FN
GN
F
P
QT
D
-
-
--
W
SP
-------------
----
---
------------QS
L
A
QDD
T
TH
M
KS
L
YAA
T
RVT
L
A
D
PLHLI
LG
A
R
-------
Y
----
--
-TNW
R
--------------
VDTLTY
-----
SM
EK
N
HT
----
TP
YA
GLVF
D
I
N
DNWS
T
YASYT
S
I
FQP
---------
Q
N
-
DR
D
SS
G
KY
-
L
A
P
I
TGNNYE
-------
LGLK
SDWM
N
SR
LT
T
T
L
AIF
R
I
E
Q
D
NVA
Q
S
---
T
GT
P
I
PGSN
GE
T
AYKAVDGTV
SKGVE
F
ELN
---
GA
I
T
D
NWQL
TF
GA
T
R
Y
I
AE
DN
-------
E
G
N
A
VN
PNLP
-----
RTTVKMF
T
SY
R
L
P
VMP
E
---
LT
V
G
-----
GGV
N
W
QN
--
R
VY
TDT
VT
PY
G
-
TFR
A
EQ
GSYALVDLFTRY
Q
VTK
----
NF
SLQGNVNNLFDKTY
D
TN
VE
GSIVY
-
--
-
G
T
PR
N
F
SI
TGTYQF
fig|316385.7.peg.1198
Escherichia coli str. K-12 substr. DH10B
M
L
ST
Q
F
NRDNQ
Y
QA
IT
KPS
L
LAGCI
A
LAL
L
P
S
A
A
F
A
A
P
ATE
ETVIV
EG
SA
T
---
AP
D
D
GEN
DY
S
V
T
ST
------
SAGTKMQM
T
QR
DIPQSVT
I
VS
Q
Q
R
ME
D
QQ
LQ
TL
G
EV
M
E
NT
L
G
I
---
-
-
S
K
S
Q
A
D
S
D
R
A
LYY
SRGF
------
QI
DNYM
--
V
DGI
P
T
YFESR
WNLGDA
LS
DM
-
AL
F
ERVEVVRG
A
T
G
L
M
T
G
TG
NP
SA
AINMV
R
K
H
AT
SRE
------------
FKGDVSAEYGS
W
NK
ER
Y
VA
D
L
Q
SP
L
TE
DG
KIR
ARIVG
GY
QN
N
D
S
W
LDRYN
SE
K
TF
------
FSG
IV
D
A
DL
G
DL
T
T
LSAG
YEY
Q
RIDVNS
P
T
WGG
----
LP
RW
N
T
D
-----
GS
S
N
SYDR
AR
ST
AP
D
WAY
ND
K
EI
N
--------
K
V
FM
TLK
Q
Q
FADTWQAT
L
N
AT
HSE
V
EFD
SKMMY
V
D
AY
VNKADGMLVGPYSNYGPGF
DY
V
G
GTG
WN
S
G
---------------------------
-
-
K
R
K
VDA
-------
--
-
--
-
-
---
-
L
D
LF
A
DG
SY
EL
FGR
QH
N
LMFGG
----------
SYSK
QN
N
RYFSSWANIFPD
EI
GSF
Y
N
FN
GN
F
P
QT
D
-
-
--
W
SP
-------------
----
---
------------QS
L
A
QDD
T
TH
M
KS
L
YAA
T
RVT
L
A
D
PLHLI
LG
A
R
-------
Y
----
--
-TNW
R
--------------
VDTLTY
-----
SM
EK
N
HT
----
TP
YA
GLVF
D
I
N
DNWS
T
YASYT
S
I
FQP
---------
Q
N
-
DR
D
SS
G
KY
-
L
A
P
I
TGNNYE
-------
LGLK
SDWM
N
SR
LT
T
T
L
AIF
R
I
E
Q
D
NVA
Q
S
---
T
GT
P
I
PGSN
GE
T
AYKAVDGTV
SKGVE
F
ELN
---
GA
I
T
D
NWQL
TF
GA
T
R
Y
I
AE
DN
-------
E
G
N
A
VN
PNLP
-----
RTTVKMF
T
SY
R
L
P
VMP
E
---
LT
V
G
-----
GGV
N
W
QN
--
R
VY
TDT
VT
PY
G
-
TFR
A
EQ
GSYALVDLFTRY
Q
VTK
----
NF
SLQGNVNNLFDKTY
D
TN
VE
GSIVY
-
--
-
G
T
PR
N
F
SI
TGTYQF
fig|511145.12.peg.1145
Escherichia coli str. K-12 substr. MG1655
M
L
ST
Q
F
NRDNQ
Y
QA
IT
KPS
L
LAGCI
A
LAL
L
P
S
A
A
F
A
A
P
ATE
ETVIV
EG
SA
T
---
AP
D
D
GEN
DY
S
V
T
ST
------
SAGTKMQM
T
QR
DIPQSVT
I
VS
Q
Q
R
ME
D
QQ
LQ
TL
G
EV
M
E
NT
L
G
I
---
-
-
S
K
S
Q
A
D
S
D
R
A
LYY
SRGF
------
QI
DNYM
--
V
DGI
P
T
YFESR
WNLGDA
LS
DM
-
AL
F
ERVEVVRG
A
T
G
L
M
T
G
TG
NP
SA
AINMV
R
K
H
AT
SRE
------------
FKGDVSAEYGS
W
NK
ER
Y
VA
D
L
Q
SP
L
TE
DG
KIR
ARIVG
GY
QN
N
D
S
W
LDRYN
SE
K
TF
------
FSG
IV
D
A
DL
G
DL
T
T
LSAG
YEY
Q
RIDVNS
P
T
WGG
----
LP
RW
N
T
D
-----
GS
S
N
SYDR
AR
ST
AP
D
WAY
ND
K
EI
N
--------
K
V
FM
TLK
Q
Q
FADTWQAT
L
N
AT
HSE
V
EFD
SKMMY
V
D
AY
VNKADGMLVGPYSNYGPGF
DY
V
G
GTG
WN
S
G
---------------------------
-
-
K
R
K
VDA
-------
--
-
--
-
-
---
-
L
D
LF
A
DG
SY
EL
FGR
QH
N
LMFGG
----------
SYSK
QN
N
RYFSSWANIFPD
EI
GSF
Y
N
FN
GN
F
P
QT
D
-
-
--
W
SP
-------------
----
---
------------QS
L
A
QDD
T
TH
M
KS
L
YAA
T
RVT
L
A
D
PLHLI
LG
A
R
-------
Y
----
--
-TNW
R
--------------
VDTLTY
-----
SM
EK
N
HT
----
TP
YA
GLVF
D
I
N
DNWS
T
YASYT
S
I
FQP
---------
Q
N
-
DR
D
SS
G
KY
-
L
A
P
I
TGNNYE
-------
LGLK
SDWM
N
SR
LT
T
T
L
AIF
R
I
E
Q
D
NVA
Q
S
---
T
GT
P
I
PGSN
GE
T
AYKAVDGTV
SKGVE
F
ELN
---
GA
I
T
D
NWQL
TF
GA
T
R
Y
I
AE
DN
-------
E
G
N
A
VN
PNLP
-----
RTTVKMF
T
SY
R
L
P
VMP
E
---
LT
V
G
-----
GGV
N
W
QN
--
R
VY
TDT
VT
PY
G
-
TFR
A
EQ
GSYALVDLFTRY
Q
VTK
----
NF
SLQGNVNNLFDKTY
D
TN
VE
GSIVY
-
--
-
G
T
PR
N
F
SI
TGTYQF
fig|511145.6.peg.1137
Escherichia coli str. K-12 substr. MG1655
M
L
ST
Q
F
NRDNQ
Y
QA
IT
KPS
L
LAGCI
A
LAL
L
P
S
A
A
F
A
A
P
ATE
ETVIV
EG
SA
T
---
AP
D
D
GEN
DY
S
V
T
ST
------
SAGTKMQM
T
QR
DIPQSVT
I
VS
Q
Q
R
ME
D
QQ
LQ
TL
G
EV
M
E
NT
L
G
I
---
-
-
S
K
S
Q
A
D
S
D
R
A
LYY
SRGF
------
QI
DNYM
--
V
DGI
P
T
YFESR
WNLGDA
LS
DM
-
AL
F
ERVEVVRG
A
T
G
L
M
T
G
TG
NP
SA
AINMV
R
K
H
AT
SRE
------------
FKGDVSAEYGS
W
NK
ER
Y
VA
D
L
Q
SP
L
TE
DG
KIR
ARIVG
GY
QN
N
D
S
W
LDRYN
SE
K
TF
------
FSG
IV
D
A
DL
G
DL
T
T
LSAG
YEY
Q
RIDVNS
P
T
WGG
----
LP
RW
N
T
D
-----
GS
S
N
SYDR
AR
ST
AP
D
WAY
ND
K
EI
N
--------
K
V
FM
TLK
Q
Q
FADTWQAT
L
N
AT
HSE
V
EFD
SKMMY
V
D
AY
VNKADGMLVGPYSNYGPGF
DY
V
G
GTG
WN
S
G
---------------------------
-
-
K
R
K
VDA
-------
--
-
--
-
-
---
-
L
D
LF
A
DG
SY
EL
FGR
QH
N
LMFGG
----------
SYSK
QN
N
RYFSSWANIFPD
EI
GSF
Y
N
FN
GN
F
P
QT
D
-
-
--
W
SP
-------------
----
---
------------QS
L
A
QDD
T
TH
M
KS
L
YAA
T
RVT
L
A
D
PLHLI
LG
A
R
-------
Y
----
--
-TNW
R
--------------
VDTLTY
-----
SM
EK
N
HT
----
TP
YA
GLVF
D
I
N
DNWS
T
YASYT
S
I
FQP
---------
Q
N
-
DR
D
SS
G
KY
-
L
A
P
I
TGNNYE
-------
LGLK
SDWM
N
SR
LT
T
T
L
AIF
R
I
E
Q
D
NVA
Q
S
---
T
GT
P
I
PGSN
GE
T
AYKAVDGTV
SKGVE
F
ELN
---
GA
I
T
D
NWQL
TF
GA
T
R
Y
I
AE
DN
-------
E
G
N
A
VN
PNLP
-----
RTTVKMF
T
SY
R
L
P
VMP
E
---
LT
V
G
-----
GGV
N
W
QN
--
R
VY
TDT
VT
PY
G
-
TFR
A
EQ
GSYALVDLFTRY
Q
VTK
----
NF
SLQGNVNNLFDKTY
D
TN
VE
GSIVY
-
--
-
G
T
PR
N
F
SI
TGTYQF
fig|749544.3.peg.1992
Escherichia coli MS 175-1
M
L
ST
Q
F
NRDNQ
Y
QA
IT
KPS
L
LAGCI
A
LAL
L
P
S
A
A
F
A
A
P
ATE
ETVIV
EG
SA
T
---
AP
D
D
GEN
DY
S
V
T
ST
------
SAGTKMQM
T
QR
DIPQSVT
I
VS
Q
Q
R
ME
D
QQ
LQ
TL
G
EV
M
E
NT
L
G
I
---
-
-
S
K
S
Q
A
D
S
D
R
A
LYY
SRGF
------
QI
DNYM
--
V
DGI
P
T
YFESR
WNLGDA
LS
DM
-
AL
F
ERVEVVRG
A
T
G
L
M
T
G
TG
NP
SA
AINMV
R
K
H
AT
SRE
------------
FKGDVSAEYGS
W
NK
ER
Y
VA
D
L
Q
SP
L
TE
DG
KIR
ARIVG
GY
QN
N
D
S
W
LDRYN
SE
K
TF
------
FSG
IV
D
A
DL
G
DL
T
T
LSAG
YEY
Q
RIDVNS
P
T
WGG
----
LP
RW
N
T
D
-----
GS
S
N
SYDR
AR
ST
AP
D
WAY
ND
K
EI
N
--------
K
V
FM
TLK
Q
Q
FAD
I
WQAT
L
N
AT
HSE
V
EFD
SKMMY
V
D
AY
VNKADGMLVGPYSNYGPGF
DY
V
G
GTG
WN
S
G
---------------------------
-
-
K
R
K
VDA
-------
--
-
--
-
-
---
-
L
D
LF
A
DG
SY
EL
FGR
QH
N
LMFGG
----------
SYSK
QN
N
RYFSSWANIFPD
EI
GSF
Y
N
FN
GN
F
P
QT
D
-
-
--
W
SP
-------------
----
---
------------QS
L
A
QDD
T
TH
M
KS
L
YAA
T
RVT
L
A
D
PLHLI
LG
A
R
-------
Y
----
--
-TNW
R
--------------
VDTLTY
-----
SM
EK
N
HT
----
TP
YA
GLVF
D
I
N
DNWS
T
YASYT
S
I
FQP
---------
Q
N
-
DR
D
SS
G
KY
-
L
A
P
I
TGNNYE
-------
LGLK
SDWM
N
SR
LT
T
T
L
AIF
R
I
E
Q
D
NVA
Q
S
---
T
GT
P
I
PGSN
GE
T
AYKAVDGTV
SKGVE
F
ELN
---
GA
I
T
D
NWQL
TF
GA
T
R
Y
I
AE
DN
-------
E
G
N
A
VN
PNLP
-----
RTTVKMF
T
SY
R
L
P
VMP
E
---
LT
V
G
-----
GGV
N
W
QN
--
R
VY
TDT
VT
PY
G
-
TFR
A
EQ
GSYALVDLFTRY
Q
VTK
----
NF
SLQGNVNNLFDKTY
D
TN
VE
GSIVY
-
--
-
G
T
PR
N
F
SI
TGTYQF
fig|562.375.peg.5050
Escherichia coli EC4100B
M
L
ST
Q
F
NRDNQ
Y
QA
IT
KPS
L
LAGCI
A
LAL
L
P
S
A
A
F
A
A
P
ATE
ETVIV
EG
SA
T
---
AP
E
D
GEN
DY
S
V
T
ST
------
SAGTKMQM
T
QR
DIPQSVT
I
VS
Q
Q
R
ME
D
QQ
LQ
TL
G
EV
M
E
NT
L
G
I
---
-
-
S
K
S
Q
A
D
S
D
R
A
LYY
SRGF
------
QI
DNYM
--
V
DGI
P
T
YFESR
WNLGDA
LS
DM
-
AL
F
ERVEVVRG
A
T
G
L
M
T
G
TG
NP
SA
AINMV
R
K
H
AT
SRE
------------
FKGDVSAEYGS
W
NK
ER
Y
VA
D
L
Q
SP
L
TE
DG
KIR
ARIVG
GY
QN
N
D
S
W
LDRYN
SE
K
TF
------
FSG
IV
D
A
DL
G
DL
T
M
LSAG
YEY
Q
RIDVNS
P
T
WGG
----
LP
RW
N
T
D
-----
GS
S
N
SYDR
AR
ST
AP
D
WAY
ND
K
EI
N
--------
K
V
FM
TLK
Q
R
FADTWQAT
L
N
AT
HSE
V
EFD
SKMMY
V
D
AY
VNKADGMLVGPYSNYGPGF
DY
V
G
GTG
WN
S
G
---------------------------
-
-
K
R
K
VDA
-------
--
-
--
-
-
---
-
L
D
LF
A
DG
SY
EL
FGR
QH
N
LMFGG
----------
SYSK
QN
N
RYFSSWANIFPD
EI
GSF
Y
N
FN
GN
F
P
QT
D
-
-
--
W
SP
-------------
----
---
------------QS
L
A
QDD
T
TH
M
KS
L
YAA
T
RVT
L
A
D
PLHLI
LG
A
R
-------
Y
----
--
-TNW
R
--------------
VDTLTY
-----
SM
EK
N
HT
----
TP
YA
GLVF
D
I
N
DNWS
T
YASYT
S
I
FQP
---------
Q
N
-
DR
D
SS
G
KY
-
L
A
P
I
TGNNYE
-------
LGLK
SDWM
N
SR
LT
T
T
L
AIF
R
I
E
Q
D
NVA
Q
S
---
T
GT
P
I
PGSN
GE
T
AYKAVDGTV
SKGVE
F
ELN
---
GA
I
T
D
NWQL
TF
GA
T
R
Y
I
AE
DN
-------
E
G
N
A
VN
PNLP
-----
RTTVKMF
T
SY
R
L
P
VMP
E
---
LT
V
G
-----
GGV
N
W
QN
--
R
VY
TDT
VT
PY
G
-
TFR
A
EQ
GSYALVDLFTRY
Q
VTK
----
NF
SLQGNVNNLFDKTY
D
TN
VE
GSIVY
-
--
-
GAPR
N
F
SI
TGTYQF
fig|656444.3.peg.1750
Escherichia coli TA280
M
L
ST
Q
F
NRDNQ
Y
QA
IT
KPS
L
LAGCI
V
LAL
L
P
S
A
A
F
A
A
P
ATE
ETVIV
EG
SA
T
---
AP
D
D
GKN
DY
S
V
T
ST
------
SAGTKMQM
T
QR
DIPQSVT
I
VS
Q
Q
R
ME
D
QQ
LQ
TL
G
EV
M
E
NT
L
G
I
---
-
-
S
K
S
Q
A
D
S
D
R
A
LYY
SRGF
------
QI
DNYM
--
V
DGI
P
T
YFESR
WNLGDA
LS
DM
-
AL
F
ERVEVVRG
A
T
G
L
M
T
G
TG
NP
SA
AINMV
R
K
H
AT
SRE
------------
FKGDVSAEYGS
W
NK
ER
Y
VA
D
L
Q
SP
L
TE
DG
KIR
ARIVG
GY
QN
N
D
S
W
LDRYN
SE
K
TF
------
FSG
IV
D
A
DL
G
DL
T
T
LSAG
YEY
Q
RIDVNS
P
T
WGG
----
LP
RW
N
T
D
-----
GS
G
N
SYDR
AR
ST
AP
D
WAY
ND
K
EI
N
--------
K
V
FM
TLK
Q
R
FADTWQAT
L
N
AT
HSE
V
EFD
SKMMY
V
D
AY
VNKADGMLVGPYSNYGPGF
DY
V
G
GTG
WN
S
G
---------------------------
-
-
K
R
K
VDA
-------
--
-
--
-
-
---
-
L
D
LF
A
DG
SY
EL
FGR
QH
N
LMFGG
----------
SYSK
QN
N
RYFSSWANIFPD
EI
GSF
Y
N
FN
GN
F
P
QT
D
-
-
--
W
SP
-------------
----
---
------------QS
L
A
QDD
T
TH
M
KS
L
YAA
T
RVT
L
A
D
PLHLI
LG
A
R
-------
Y
----
--
-TNW
R
--------------
VDTLTY
-----
SM
EK
N
HT
----
TP
YA
GLVF
D
I
N
DNWS
T
YASYT
S
I
FQP
---------
Q
N
-
DR
D
SS
G
KY
-
L
A
P
I
TGNNYE
-------
LGLK
SDWM
N
SR
LT
T
T
L
AIF
R
I
E
Q
D
NVA
Q
S
---
T
GT
P
I
PGSN
GE
T
AYKAVDGTV
SKGVE
F
ELN
---
GA
I
T
D
NWQL
TF
GA
T
R
Y
I
AE
DN
-------
E
G
N
A
VN
PNLP
-----
RTTVKMF
T
SY
R
L
P
VMP
E
---
LT
V
G
-----
GGV
N
W
QN
--
R
VY
TDT
VT
PY
G
-
TFR
A
EQ
GSYALVDLFTRY
Q
VTK
----
NF
SLQGNVNNLFDKTY
D
TN
VE
GSIVY
-
--
-
GAPR
N
F
SI
TGTYQF
fig|656437.3.peg.1246
Escherichia coli TA143
M
L
ST
Q
F
NRDNQ
Y
QA
IT
KPS
L
LAGCI
V
LAL
L
P
S
A
A
F
A
A
P
ATE
ETVIV
EG
SA
T
---
AP
D
D
GEN
DY
S
V
T
ST
------
SAGTKMQM
T
QR
DIPQSVT
I
VS
Q
Q
R
ME
D
QQ
LQ
TL
G
EV
M
E
NT
L
G
I
---
-
-
S
K
S
Q
A
D
S
D
R
A
LYY
SRGF
------
QI
DNYM
--
V
DGI
P
T
YFESR
WNLGDA
LS
DM
-
AL
F
ERVEVVRG
A
T
G
L
M
T
G
TG
NP
SA
AINMV
R
K
H
AT
SRE
------------
FKGDVSAEYGS
W
NK
ER
Y
VA
D
L
Q
SP
L
TE
DG
KIR
ARIVG
GY
QN
N
D
S
W
LDRYN
SE
K
TF
------
FSG
IV
D
A
DL
G
DL
T
T
LSAG
YEY
Q
RIDVNS
P
T
WGG
----
LP
RW
N
T
D
-----
GS
S
N
SYDR
AR
ST
AP
D
WAY
ND
K
EI
N
--------
K
V
FM
TLK
Q
R
FADTWQAT
L
N
AT
HSE
V
EFD
SKMMY
V
D
AY
VNKADGMLVGPYSNYGPGF
DY
V
G
GTG
WN
S
G
---------------------------
-
-
K
R
K
VDA
-------
--
-
--
-
-
---
-
L
D
LF
A
DG
SY
EL
FGR
QH
N
LMFGG
----------
SYSK
QN
N
RYFSSWANIFPD
E
M
GSF
Y
N
FN
GN
F
P
QT
D
-
-
--
W
SP
-------------
----
---
------------QS
L
A
QDD
T
TH
M
KS
L
YAA
T
RVT
L
A
D
PLHLI
LG
A
R
-------
Y
----
--
-TNW
R
--------------
VDTLTY
-----
SM
EK
N
HT
----
TP
YA
GLVF
D
I
N
DNWS
T
YASYT
S
I
FQP
---------
Q
N
-
DR
D
SS
G
KY
-
L
A
P
I
I
GNNYE
-------
LGLK
SDWM
N
SR
LT
T
T
L
AIF
R
I
E
Q
D
NVA
Q
S
---
T
GT
P
I
PGSN
GE
T
AYKAVDGTV
SKGVE
F
ELN
---
GA
I
T
D
NWQL
TF
GA
T
R
Y
I
AE
DN
-------
E
G
N
A
VN
PNLP
-----
RTTVKMF
T
R
Y
R
L
P
VMP
E
---
LT
V
G
-----
GGV
N
W
QN
--
R
VY
TDT
VT
PY
G
-
TFR
A
EQ
GSYALVDLFTRY
Q
VTK
----
NF
SLQGNVNNLFDKTY
D
TN
VE
GSIVY
-
--
-
GAPR
N
F
SI
TGTYQF
fig|595495.4.peg.1833
Escherichia coli KO11
M
L
ST
Q
F
NRDNQ
Y
QA
IT
KPS
L
LAGCI
A
LAL
L
P
S
A
A
F
A
A
P
ATE
ETVIV
EG
SA
T
---
AP
D
D
GEN
DY
S
V
T
ST
------
SAGTKMQM
T
QR
DIPQSVT
I
VS
Q
Q
R
ME
D
QQ
LQ
TL
G
EV
M
E
NT
Q
G
I
---
-
-
S
K
S
Q
A
D
S
D
R
A
LYY
SRGF
------
QI
DNYM
--
V
DGI
P
T
YFESR
WNLGDA
LS
DM
-
AL
F
ERVEVVRG
A
T
G
L
M
T
G
TG
NP
SA
AINMV
R
K
H
AT
SRE
------------
FKGDVSAEYGS
W
NK
ER
Y
VA
D
L
Q
SP
L
TE
DG
KIR
ARIVG
GY
QN
N
D
S
W
LDRYN
SE
K
TF
------
FSG
IV
D
A
DL
G
DL
T
T
LSAG
YEY
Q
RIDVNS
P
T
WGG
----
LP
RW
N
T
D
-----
GS
S
N
SYDR
AR
ST
AP
D
WAY
ND
K
EI
N
--------
K
V
FM
TLK
Q
R
FADTWQAT
L
N
AT
HSE
V
EFD
SKMMY
V
D
AY
VNKADGMLVGPYSNYGPGF
DY
V
G
GTG
WN
S
G
---------------------------
-
-
K
R
K
VDA
-------
--
-
--
-
-
---
-
L
D
LF
A
DG
SY
EL
FGR
QH
N
LMFGG
----------
SYSK
QN
N
RYFSSWANIFPD
EI
GSF
Y
N
FN
GN
F
P
QT
D
-
-
--
W
SP
-------------
----
---
------------QS
L
A
QDD
T
TH
M
KS
L
YAA
T
RVT
L
A
D
PLHLI
LG
A
R
-------
Y
----
--
-TNW
R
--------------
VDTLTY
-----
SM
EK
N
HT
----
TP
YA
GLVF
D
I
N
DNWS
T
YASYT
S
I
FQP
---------
Q
N
-
DR
D
SS
G
KY
-
L
A
P
I
TGNNYE
-------
LGLK
SDWM
N
SR
LT
T
T
L
AIF
R
I
E
Q
D
NVA
Q
S
---
T
GT
P
I
PGSN
GE
T
AYKAVDGTV
SKGVE
F
ELN
---
GA
I
T
D
NWQL
TF
GA
T
R
Y
I
AE
DN
-------
E
G
N
A
VN
PNLP
-----
RTTVKMF
T
SY
R
L
P
VMP
E
---
LT
V
G
-----
GGV
N
W
QN
--
R
VY
TDT
VT
PY
G
-
TFR
A
EQ
GSYALVDLFTRY
Q
VTK
----
NF
SLQGNVNNLFDKTY
D
TN
VE
GSIVY
-
--
-
GAPR
N
F
SI
TGTYQF
fig|679206.4.peg.890
Escherichia coli MS 119-7
M
L
ST
Q
F
NRDNQ
Y
QA
IT
KPS
L
LAGCI
A
LAL
L
P
S
A
A
F
A
A
P
ATE
ETVIV
EG
SA
T
---
AP
D
D
GEN
DY
S
V
T
ST
------
SAGTKMQM
T
QR
DIPQSVT
I
VS
Q
Q
R
ME
D
QQ
LQ
TL
G
EV
M
E
NT
Q
G
I
---
-
-
S
K
S
Q
A
D
S
D
R
A
LYY
SRGF
------
QI
DNYM
--
V
DGI
P
T
YFESR
WNLGDA
LS
DM
-
AL
F
ERVEVVRG
A
T
G
L
M
T
G
TG
NP
SA
AINMV
R
K
H
AT
SRE
------------
FKGDVSAEYGS
W
NK
ER
Y
VA
D
L
Q
SP
L
TE
DG
KIR
ARIVG
GY
QN
N
D
S
W
LDRYN
SE
K
TF
------
FSG
IV
D
A
DL
G
DL
T
T
LSAG
YEY
Q
RIDVNS
P
T
WGG
----
LP
RW
N
T
D
-----
GS
S
N
SYDR
AR
ST
AP
D
WAY
ND
K
EI
N
--------
K
V
FM
TLK
Q
R
FADTWQAT
L
N
AT
HSE
V
EFD
SKMMY
V
D
AY
VNKADGMLVGPYSNYGPGF
DY
V
G
GTG
WN
S
G
---------------------------
-
-
K
R
K
VDA
-------
--
-
--
-
-
---
-
L
D
LF
A
DG
SY
EL
FGR
QH
N
LMFGG
----------
SYSK
QN
N
RYFSSWANIFPD
EI
GSF
Y
N
FN
GN
F
P
QT
D
-
-
--
W
SP
-------------
----
---
------------QS
L
A
QDD
T
TH
M
KS
L
YAA
T
RVT
L
A
D
PLHLI
LG
A
R
-------
Y
----
--
-TNW
R
--------------
VDTLTY
-----
SM
EK
N
HT
----
TP
YA
GLVF
D
I
N
DNWS
T
YASYT
S
I
FQP
---------
Q
N
-
DR
D
SS
G
KY
-
L
A
P
I
TGNNYE
-------
LGLK
SDWM
N
SR
LT
T
T
L
AIF
R
I
E
Q
D
NVA
Q
S
---
T
GT
P
I
PGSN
GE
T
AYKAVDGTV
SKGVE
F
ELN
---
GA
I
T
D
NWQL
TF
GA
T
R
Y
I
AE
DN
-------
E
G
N
A
VN
PNLP
-----
RTTVKMF
T
SY
R
L
P
VMP
E
---
LT
V
G
-----
GGV
N
W
QN
--
R
VY
TDT
VT
PY
G
-
TFR
A
EQ
GSYALVDLFTRY
Q
VTK
----
NF
SLQGNVNNLFDKTY
D
TN
VE
GSIVY
-
--
-
GAPR
N
F
SI
TGTYQF
fig|749545.3.peg.819
Escherichia coli MS 182-1
M
L
ST
Q
F
NRDNQ
Y
QA
IT
KPS
L
LAGCI
A
LAL
L
P
S
A
A
F
A
A
P
ATE
ETVIV
EG
SA
T
---
AP
D
D
GEN
DY
S
V
T
ST
------
SAGTKMQM
T
QR
DIPQSVT
I
VS
Q
Q
R
ME
D
QQ
LQ
TL
G
EV
M
E
NT
Q
G
I
---
-
-
S
K
S
Q
A
D
S
D
R
A
LYY
SRGF
------
QI
DNYM
--
V
DGI
P
T
YFESR
WNLGDA
LS
DM
-
AL
F
ERVEVVRG
A
T
G
L
M
T
G
TG
NP
SA
AINMV
R
K
H
AT
SRE
------------
FKGDVSAEYGS
W
NK
ER
Y
VA
D
L
Q
SP
L
TE
DG
KIR
ARIVG
GY
QN
N
D
S
W
LDRYN
SE
K
TF
------
FSG
IV
D
A
DL
G
DL
T
T
LSAG
YEY
Q
RIDVNS
P
T
WGG
----
LP
RW
N
T
D
-----
GS
S
N
SYDR
AR
ST
AP
D
WAY
ND
K
EI
N
--------
K
V
FM
TLK
Q
R
FADTWQAT
L
N
AT
HSE
V
EFD
SKMMY
V
D
AY
VNKADGMLVGPYSNYGPGF
DY
V
G
GTG
WN
S
G
---------------------------
-
-
K
R
K
VDA
-------
--
-
--
-
-
---
-
L
D
LF
A
DG
SY
EL
FGR
QH
N
LMFGG
----------
SYSK
QN
N
RYFSSWANIFPD
EI
GSF
Y
N
FN
GN
F
P
QT
D
-
-
--
W
SP
-------------
----
---
------------QS
L
A
QDD
T
TH
M
KS
L
YAA
T
RVT
L
A
D
PLHLI
LG
A
R
-------
Y
----
--
-TNW
R
--------------
VDTLTY
-----
SM
EK
N
HT
----
TP
YA
GLVF
D
I
N
DNWS
T
YASYT
S
I
FQP
---------
Q
N
-
DR
D
SS
G
KY
-
L
A
P
I
TGNNYE
-------
LGLK
SDWM
N
SR
LT
T
T
L
AIF
R
I
E
Q
D
NVA
Q
S
---
T
GT
P
I
PGSN
GE
T
AYKAVDGTV
SKGVE
F
ELN
---
GA
I
T
D
NWQL
TF
GA
T
R
Y
I
AE
DN
-------
E
G
N
A
VN
PNLP
-----
RTTVKMF
T
SY
R
L
P
VMP
E
---
LT
V
G
-----
GGV
N
W
QN
--
R
VY
TDT
VT
PY
G
-
TFR
A
EQ
GSYALVDLFTRY
Q
VTK
----
NF
SLQGNVNNLFDKTY
D
TN
VE
GSIVY
-
--
-
GAPR
N
F
SI
TGTYQF
fig|749532.3.peg.3327
Escherichia coli MS 78-1
M
L
ST
Q
F
NRDNQ
Y
QA
IT
KPS
L
LAGCI
A
LAL
L
P
S
A
A
F
A
A
P
ATE
ETVIV
EG
SA
T
---
AP
D
D
GEN
DY
S
V
T
ST
------
SAGTKMQM
T
QR
DIPQSVT
I
VS
Q
Q
R
ME
D
QQ
LQ
TL
G
EV
M
E
NT
Q
G
I
---
-
-
S
K
S
Q
A
D
S
D
R
A
LYY
SRGF
------
QI
DNYM
--
V
DGI
P
T
YFESR
WNLGDA
LS
DM
-
AL
F
ERVEVVRG
A
T
G
L
M
T
G
TG
NP
SA
AINMV
R
K
H
AT
SRE
------------
FKGDVSAEYGS
W
NK
ER
Y
VA
D
L
Q
SP
L
TE
DG
KIR
ARIVG
GY
QN
N
D
S
W
LDRYN
SE
K
TF
------
FSG
IV
D
A
DL
G
DL
T
T
LSAG
YEY
Q
RIDVNS
P
T
WGG
----
LP
RW
N
T
D
-----
GS
S
N
SYDR
AR
ST
AP
D
WAY
ND
K
EI
N
--------
K
V
FM
TLK
Q
R
FADTWQAT
L
N
AT
HSE
V
EFD
SKMMY
V
D
AY
VNKADGMLVGPYSNYGPGF
DY
V
G
GTG
WN
S
G
---------------------------
-
-
K
R
K
VDA
-------
--
-
--
-
-
---
-
L
D
LF
A
DG
SY
EL
FGR
QH
N
LMFGG
----------
SYSK
QN
N
RYFSSWANIFPD
EI
GSF
Y
N
FN
GN
F
P
QT
D
-
-
--
W
SP
-------------
----
---
------------QS
L
A
QDD
T
TH
M
KS
L
YAA
T
RVT
L
A
D
PLHLI
LG
A
R
-------
Y
----
--
-TNW
R
--------------
VDTLTY
-----
SM
EK
N
HT
----
TP
YA
GLVF
D
I
N
DNWS
T
YASYT
S
I
FQP
---------
Q
N
-
DR
D
SS
G
KY
-
L
A
P
I
TGNNYE
-------
LGLK
SDWM
N
SR
LT
T
T
L
AIF
R
I
E
Q
D
NVA
Q
S
---
T
GT
P
I
PGSN
GE
T
AYKAVDGTV
SKGVE
F
ELN
---
GA
I
T
D
NWQL
TF
GA
T
R
Y
I
AE
DN
-------
E
G
N
A
VN
PNLP
-----
RTTVKMF
T
SY
R
L
P
VMP
E
---
LT
V
G
-----
GGV
N
W
QN
--
R
VY
TDT
VT
PY
G
-
TFR
A
EQ
GSYALVDLFTRY
Q
VTK
----
NF
SLQGNVNNLFDKTY
D
TN
VE
GSIVY
-
--
-
GAPR
N
F
SI
TGTYQF
fig|656443.3.peg.1433
Escherichia coli TA271
M
L
ST
Q
F
NRDNQ
Y
QA
IT
KPS
L
LAGCI
A
LAL
L
P
S
A
A
F
A
A
P
ATE
ETVIV
EG
SA
T
---
AP
D
D
GEN
DY
S
V
T
ST
------
SAGTKMQM
T
QR
DIPQSVT
I
VS
Q
Q
R
ME
D
QQ
LQ
TL
G
EV
M
E
NT
Q
G
I
---
-
-
S
K
S
Q
A
D
S
D
R
A
LYY
SRGF
------
QI
DNYM
--
V
DGI
P
T
YFESR
WNLGDA
LS
DM
-
AL
F
ERVEVVRG
A
T
G
L
M
T
G
TG
NP
SA
AINMV
R
K
H
AT
SRE
------------
FKGDVSAEYGS
W
NK
ER
Y
VA
D
L
Q
SP
L
TE
DG
KIR
ARIVG
GY
QN
N
D
S
W
LDRYN
SE
K
TF
------
FSG
IV
D
A
DL
G
DL
T
T
LSAG
YEY
Q
RIDVNS
P
T
WGG
----
LP
RW
N
T
D
-----
GS
S
N
SYDR
AR
ST
AP
D
WAY
ND
K
EI
N
--------
K
V
FM
TLK
Q
R
FADTWQAT
L
N
AT
HSE
V
EFD
SKMMY
V
D
AY
VNKADGMLVGPYSNYGPGF
DY
V
G
GTG
WN
S
G
---------------------------
-
-
K
R
K
VDA
-------
--
-
--
-
-
---
-
L
D
LF
A
DG
SY
EL
FGR
QH
N
LMFGG
----------
SYSK
QN
N
RYFSSWANIFPD
EI
GSF
Y
N
FN
GN
F
P
QT
D
-
-
--
W
SP
-------------
----
---
------------QS
L
A
QDD
T
TH
M
KS
L
YAA
T
RVT
L
A
D
PLHLI
LG
A
R
-------
Y
----
--
-TNW
R
--------------
VDTLTY
-----
SM
EK
N
HT
----
TP
YA
GLVF
D
I
N
DNWS
T
YASYT
S
I
FQP
---------
Q
N
-
DR
D
SS
G
KY
-
L
A
P
I
TGNNYE
-------
LGLK
SDWM
N
SR
LT
T
T
L
AIF
R
I
E
Q
D
NVA
Q
S
---
T
GT
P
I
PGSN
GE
T
AYKAVDGTV
SKGVE
F
ELN
---
GA
I
T
D
NWQL
TF
GA
T
R
Y
I
AE
DN
-------
E
G
N
A
VN
PNLP
-----
RTTVKMF
T
SY
R
L
P
VMP
E
---
LT
V
G
-----
GGV
N
W
QN
--
R
VY
TDT
VT
PY
G
-
TFR
A
EQ
GSYALVDLFTRY
Q
VTK
----
NF
SLQGNVNNLFDKTY
D
TN
VE
GSIVY
-
--
-
GAPR
N
F
SI
TGTYQF
fig|566546.3.peg.394
Escherichia coli W
M
L
ST
Q
F
NRDNQ
Y
QA
IT
KPS
L
LAGCI
A
LAL
L
P
S
A
A
F
A
A
P
ATE
ETVIV
EG
SA
T
---
AP
D
D
GEN
DY
S
V
T
ST
------
SAGTKMQM
T
QR
DIPQSVT
I
VS
Q
Q
R
ME
D
QQ
LQ
TL
G
EV
M
E
NT
Q
G
I
---
-
-
S
K
S
Q
A
D
S
D
R
A
LYY
SRGF
------
QI
DNYM
--
V
DGI
P
T
YFESR
WNLGDA
LS
DM
-
AL
F
ERVEVVRG
A
T
G
L
M
T
G
TG
NP
SA
AINMV
R
K
H
AT
SRE
------------
FKGDVSAEYGS
W
NK
ER
Y
VA
D
L
Q
SP
L
TE
DG
KIR
ARIVG
GY
QN
N
D
S
W
LDRYN
SE
K
TF
------
FSG
IV
D
A
DL
G
DL
T
T
LSAG
YEY
Q
RIDVNS
P
T
WGG
----
LP
RW
N
T
D
-----
GS
S
N
SYDR
AR
ST
AP
D
WAY
ND
K
EI
N
--------
K
V
FM
TLK
Q
R
FADTWQAT
L
N
AT
HSE
V
EFD
SKMMY
V
D
AY
VNKADGMLVGPYSNYGPGF
DY
V
G
GTG
WN
S
G
---------------------------
-
-
K
R
K
VDA
-------
--
-
--
-
-
---
-
L
D
LF
A
DG
SY
EL
FGR
QH
N
LMFGG
----------
SYSK
QN
N
RYFSSWANIFPD
EI
GSF
Y
N
FN
GN
F
P
QT
D
-
-
--
W
SP
-------------
----
---
------------QS
L
A
QDD
T
TH
M
KS
L
YAA
T
RVT
L
A
D
PLHLI
LG
A
R
-------
Y
----
--
-TNW
R
--------------
VDTLTY
-----
SM
EK
N
HT
----
TP
YA
GLVF
D
I
N
DNWS
T
YASYT
S
I
FQP
---------
Q
N
-
DR
D
SS
G
KY
-
L
A
P
I
TGNNYE
-------
LGLK
SDWM
N
SR
LT
T
T
L
AIF
R
I
E
Q
D
NVA
Q
S
---
T
GT
P
I
PGSN
GE
T
AYKAVDGTV
SKGVE
F
ELN
---
GA
I
T
D
NWQL
TF
GA
T
R
Y
I
AE
DN
-------
E
G
N
A
VN
PNLP
-----
RTTVKMF
T
SY
R
L
P
VMP
E
---
LT
V
G
-----
GGV
N
W
QN
--
R
VY
TDT
VT
PY
G
-
TFR
A
EQ
GSYALVDLFTRY
Q
VTK
----
NF
SLQGNVNNLFDKTY
D
TN
VE
GSIVY
-
--
-
GAPR
N
F
SI
TGTYQF
fig|566546.4.peg.1205
Escherichia coli W
M
L
ST
Q
F
NRDNQ
Y
QA
IT
KPS
L
LAGCI
A
LAL
L
P
S
A
A
F
A
A
P
ATE
ETVIV
EG
SA
T
---
AP
D
D
GEN
DY
S
V
T
ST
------
SAGTKMQM
T
QR
DIPQSVT
I
VS
Q
Q
R
ME
D
QQ
LQ
TL
G
EV
M
E
NT
Q
G
I
---
-
-
S
K
S
Q
A
D
S
D
R
A
LYY
SRGF
------
QI
DNYM
--
V
DGI
P
T
YFESR
WNLGDA
LS
DM
-
AL
F
ERVEVVRG
A
T
G
L
M
T
G
TG
NP
SA
AINMV
R
K
H
AT
SRE
------------
FKGDVSAEYGS
W
NK
ER
Y
VA
D
L
Q
SP
L
TE
DG
KIR
ARIVG
GY
QN
N
D
S
W
LDRYN
SE
K
TF
------
FSG
IV
D
A
DL
G
DL
T
T
LSAG
YEY
Q
RIDVNS
P
T
WGG
----
LP
RW
N
T
D
-----
GS
S
N
SYDR
AR
ST
AP
D
WAY
ND
K
EI
N
--------
K
V
FM
TLK
Q
R
FADTWQAT
L
N
AT
HSE
V
EFD
SKMMY
V
D
AY
VNKADGMLVGPYSNYGPGF
DY
V
G
GTG
WN
S
G
---------------------------
-
-
K
R
K
VDA
-------
--
-
--
-
-
---
-
L
D
LF
A
DG
SY
EL
FGR
QH
N
LMFGG
----------
SYSK
QN
N
RYFSSWANIFPD
EI
GSF
Y
N
FN
GN
F
P
QT
D
-
-
--
W
SP
-------------
----
---
------------QS
L
A
QDD
T
TH
M
KS
L
YAA
T
RVT
L
A
D
PLHLI
LG
A
R
-------
Y
----
--
-TNW
R
--------------
VDTLTY
-----
SM
EK
N
HT
----
TP
YA
GLVF
D
I
N
DNWS
T
YASYT
S
I
FQP
---------
Q
N
-
DR
D
SS
G
KY
-
L
A
P
I
TGNNYE
-------
LGLK
SDWM
N
SR
LT
T
T
L
AIF
R
I
E
Q
D
NVA
Q
S
---
T
GT
P
I
PGSN
GE
T
AYKAVDGTV
SKGVE
F
ELN
---
GA
I
T
D
NWQL
TF
GA
T
R
Y
I
AE
DN
-------
E
G
N
A
VN
PNLP
-----
RTTVKMF
T
SY
R
L
P
VMP
E
---
LT
V
G
-----
GGV
N
W
QN
--
R
VY
TDT
VT
PY
G
-
TFR
A
EQ
GSYALVDLFTRY
Q
VTK
----
NF
SLQGNVNNLFDKTY
D
TN
VE
GSIVY
-
--
-
GAPR
N
F
SI
TGTYQF
fig|679204.3.peg.3643
Escherichia coli MS 145-7
M
L
ST
Q
F
NRDNQ
Y
QA
IT
KPS
L
LAGCI
A
LAL
L
P
S
A
A
F
A
A
P
ATE
ETVIV
EG
SA
T
---
AP
D
D
GEN
DY
S
V
T
ST
------
SAGTKMQM
T
QR
DIPQSVT
I
VS
Q
Q
R
ME
D
QQ
LQ
TL
G
EV
M
E
NT
Q
G
I
---
-
-
S
K
S
Q
A
D
S
D
R
A
LYY
SRGF
------
QI
DNYM
--
V
DGI
P
T
YFESR
WNLGDA
LS
DM
-
AL
F
ERVEVVRG
A
T
G
L
M
T
G
TG
NP
SA
AINMV
R
K
H
AT
SRE
------------
FKGDVSAEYGS
W
NK
ER
Y
VA
D
L
Q
SP
L
TE
DG
KIR
ARIVG
GY
QN
N
D
S
W
LDRYN
SE
K
TF
------
FSG
IV
D
A
DL
G
DL
T
M
LSAG
YEY
Q
RIDVNS
P
T
WGG
----
LP
RW
N
T
D
-----
GS
S
N
SYDR
AR
ST
AP
D
WAY
ND
K
EI
N
--------
K
V
FM
TLK
Q
R
FADTWQAT
L
N
AT
HSE
V
EFD
SKMMY
V
D
AY
VNKADGMLVGPYSNYGPGF
DY
V
G
GTG
WN
S
G
---------------------------
-
-
K
R
K
VDA
-------
--
-
--
-
-
---
-
L
D
LF
A
DG
SY
EL
FGR
QH
N
LMFGG
----------
SYSK
QN
N
RYFSSWANIFPD
EI
GSF
Y
N
FN
GN
F
P
QT
D
-
-
--
W
SP
-------------
----
---
------------QS
L
A
QDD
T
TH
M
KS
L
YAA
T
RVT
L
A
D
PLHLI
LG
A
R
-------
Y
----
--
-TNW
R
--------------
VDTLTY
-----
SM
EK
N
HT
----
TP
YA
GLVF
D
I
N
DNWS
T
YASYT
S
I
FQP
---------
Q
N
-
DR
D
SS
G
KY
-
L
A
P
I
TGNNYE
-------
LGLK
SDWM
N
SR
LT
T
T
L
AIF
R
I
E
Q
D
NVA
Q
S
---
T
GT
P
I
PGSN
GE
T
AYKAVDGTV
SKGVE
F
ELN
---
GA
I
T
D
NWQL
TF
GA
T
R
Y
I
AE
DN
-------
E
G
N
A
VN
PNLP
-----
RTTVKMF
T
SY
R
L
P
VMP
E
---
LT
V
G
-----
GGV
N
W
QN
--
R
VY
TDT
VT
PY
G
-
TFR
A
EQ
GSYALVDLFTRY
Q
VTK
----
NF
SLQGNVNNLFDKTY
D
TN
VE
GSIVY
-
--
-
GAPR
N
F
SI
TGTYQF
fig|656408.3.peg.1177
Escherichia coli H591
M
L
ST
Q
F
NRDNQ
Y
QA
IT
KPS
L
LAGCI
A
LAL
L
P
S
A
A
F
A
A
P
ATE
ETVIV
EG
SA
T
---
AP
D
D
GEN
DY
S
V
T
ST
------
SAGTKMQM
T
QR
DIPQSVT
I
VS
Q
Q
R
ME
D
QQ
LQ
TL
G
EV
M
E
NT
Q
G
I
---
-
-
S
K
S
Q
A
D
S
D
R
A
LYY
SRGF
------
QI
DNYM
--
V
DGI
P
T
YFESR
WNLGDA
LS
DM
-
AL
F
ERVEVVRG
A
T
G
L
M
T
G
TG
NP
SA
AINMV
R
K
H
AT
SRE
------------
FKGDVSAEYGS
W
NK
ER
Y
VA
D
L
Q
SP
L
TE
DG
KIR
ARIVG
GY
QN
N
D
S
W
LDRYN
SE
K
TF
------
FSG
IV
D
A
DL
G
DL
T
T
LSAG
YEY
Q
RIDVNS
P
T
WGG
----
LP
RW
N
T
D
-----
GS
S
N
SYDR
AR
ST
AP
D
WAY
ND
K
EI
N
--------
K
V
FM
TLK
Q
R
FADTWQAT
L
N
AT
HSE
V
EFD
SKMMY
V
D
AY
VNKADGMLVGPYSNYGPGF
DY
V
G
GTG
WN
S
G
---------------------------
-
-
K
R
K
VDA
-------
--
-
--
-
-
---
-
L
D
LF
A
H
G
SY
EL
FGR
QH
N
LMFGG
----------
SYSK
QN
N
RYFSSWANIFPD
EI
GSF
Y
N
FN
GN
F
P
QT
D
-
-
--
W
SP
-------------
----
---
------------QS
L
A
QDD
T
TH
M
KS
L
YAA
T
RVT
L
A
D
PLHLI
LG
A
R
-------
Y
----
--
-TNW
R
--------------
VDTLTY
-----
SM
EK
N
HT
----
TP
YA
GLVF
D
I
N
DNWS
T
YASYT
S
I
FQP
---------
Q
N
-
DR
D
SS
G
KY
-
L
A
P
I
TGNNYE
-------
LGLK
SDWM
N
SR
LT
T
T
L
AIF
R
I
E
Q
D
NVA
Q
S
---
T
GT
P
I
PGSN
GE
T
AYKAVDGTV
SKGVE
F
ELN
---
GA
I
T
D
NWQL
TF
GA
T
R
Y
I
AE
DN
-------
E
G
N
A
VN
PNLP
-----
RTTVKMF
T
SY
R
L
P
VMP
E
---
LT
V
G
-----
GGV
N
W
QN
--
R
VY
TDT
VT
PY
G
-
TFR
A
EQ
GSYALVDLFTRY
Q
VTK
----
NF
SLQGNVNNLFDKTY
D
TN
VE
GSIVY
-
--
-
GAPR
N
F
SI
TGTYQF
fig|409438.11.peg.1301
Escherichia coli SE11
M
L
ST
Q
F
NRDNQ
Y
QA
ST
KPS
L
LAGCI
A
LAL
L
P
S
A
A
F
A
A
P
ATE
ETVIV
EG
SA
T
---
AP
D
D
GEN
DY
S
V
T
ST
------
SAGTKMQM
T
QR
DIPQSVT
I
VS
Q
Q
R
ME
D
QQ
LQ
TL
G
EV
M
E
NT
L
G
I
---
-
-
S
K
S
Q
A
D
S
D
R
A
LYY
SRGF
------
QI
DNYM
--
V
DGI
P
T
YFESR
WNLGDA
LS
DM
-
AL
F
ERVEVVRG
A
T
G
L
M
T
G
TG
NP
SA
AINMV
R
K
H
AT
SRE
------------
FKGDVSAEYGS
W
NK
ER
Y
VA
D
L
Q
SP
L
TE
DG
KIR
ARIVG
GY
QN
N
D
S
W
LDRYN
SE
K
TF
------
FSG
IV
D
A
DL
G
DL
T
T
LSAG
YEY
Q
RIDVNS
P
T
WGG
----
LP
RW
N
T
D
-----
GS
S
N
SYDR
AR
ST
AP
D
WAY
ND
K
EI
N
--------
K
V
FM
TLK
Q
R
FADTWQAT
L
N
AT
HSE
V
EFD
SKMMY
V
D
AY
VNKADGMLVGPYSNYGPGF
DY
V
G
GTG
WN
S
G
---------------------------
-
-
K
R
K
VDA
-------
--
-
--
-
-
---
-
L
D
LF
A
DG
SY
EL
FGR
QH
N
LMFGG
----------
SYSK
QN
N
RYFSSWANIFPD
EI
GSF
Y
N
FN
GN
F
P
QT
D
-
-
--
W
SP
-------------
----
---
------------QS
L
A
QDD
T
TH
M
KS
L
YAA
T
RVT
L
A
D
PLHLI
LG
A
R
-------
Y
----
--
-TNW
R
--------------
VDTLTY
-----
SM
EK
N
HT
----
TP
YA
GLVF
D
I
N
DNWS
T
YASYT
S
I
FQP
---------
Q
N
-
DR
D
SS
G
KY
-
L
A
P
I
TGNNYE
-------
LGLK
SDWM
N
SR
LT
T
T
L
AIF
R
I
E
Q
D
NVA
Q
S
---
T
GT
P
I
PGSN
GE
T
AYKAVDGTV
SKGVE
F
ELN
---
GA
I
T
D
NWQL
TF
GA
T
R
Y
I
AE
DN
-------
E
G
N
A
VN
PNLP
-----
RTTVKMF
T
SY
R
L
P
VMP
E
---
LT
V
G
-----
GGV
N
W
QN
--
R
VY
TDT
VT
PY
G
-
TFR
A
EQ
GSYALVDLFTRY
Q
VTK
----
NF
SLQGNVNNLFDKTY
D
TN
VE
GSIVY
-
--
-
GAPR
N
F
SI
TGTYQF
fig|753642.3.peg.2210
Escherichia coli NC101
M
L
ST
Q
F
NRDNQ
H
QA
II
KPS
L
LAGCI
A
LAL
L
P
S
A
A
F
A
A
P
ATE
ETVIV
EG
SA
T
---
AP
D
D
GEN
DY
N
V
T
ST
------
SAGTKMQM
T
QR
DIPQSVT
I
VS
Q
Q
R
ME
D
QQ
LQ
TL
G
EV
M
E
NT
L
G
I
---
-
-
S
K
S
Q
A
D
S
D
R
A
LYY
SRGF
------
QI
DNYM
--
V
DGI
P
T
YFESR
WNLGDA
LS
DM
-
AL
F
ERVEVVRG
A
T
G
L
M
T
G
TG
NP
SA
AINMV
R
K
H
AT
SRE
------------
FKGDVSAEYGS
W
NK
ER
Y
VA
D
L
Q
SP
L
TE
DG
KIR
ARIVG
GY
QN
N
D
S
W
LDRYN
SE
K
TF
------
FSG
IV
D
A
DL
G
DL
T
M
LSAG
YEY
Q
RIDVNS
P
T
WGG
----
LP
RW
N
T
D
-----
GS
S
N
SYDR
AR
ST
AP
D
WAY
ND
K
EI
N
--------
K
V
FM
TLK
Q
R
FADTWQAT
L
N
AT
HSE
V
EFD
SKMMY
V
D
AY
VNKADGMLVGPYSNYGPGF
DY
V
G
GTG
WN
S
G
---------------------------
-
-
K
R
K
VDA
-------
--
-
--
-
-
---
-
L
D
LF
A
DG
SY
EL
FGR
QH
N
LMFGG
----------
SYSK
QN
N
RYFSSWANIFPD
EI
GSF
Y
N
FN
GN
F
P
QT
D
-
-
--
W
SP
-------------
----
---
------------QS
L
A
QDD
T
TH
M
KS
L
YAA
T
RVT
L
A
D
PLHLI
LG
A
R
-------
Y
----
--
-TNW
R
--------------
VDTLTY
-----
SM
EK
N
HT
----
TP
YA
GLVF
D
I
N
DNWS
T
YASYT
S
I
FQP
---------
Q
N
-
DR
D
SS
G
KY
-
L
T
P
I
TGNNYE
-------
LGLK
SDWM
N
SR
LT
T
T
L
AIF
R
I
E
Q
D
NVA
Q
S
---
T
GT
P
I
PGSN
GE
T
AYKAVDGTV
SKGVE
F
ELN
---
GA
I
T
D
NWQL
TF
GA
T
R
Y
I
AE
DN
-------
E
G
N
A
VN
PNLP
-----
RTTVKMF
T
SY
R
L
P
VMP
E
---
LT
V
G
-----
GGV
N
W
QN
--
R
VY
TDT
VT
PY
G
-
TFR
A
EQ
GSYALVDLFTRY
Q
VTK
----
NF
SLQGNVNNLFDKTY
D
TN
VE
GSIVY
-
--
-
GAPR
N
F
SI
TGTYQF
fig|656440.3.peg.1016
Escherichia coli TA206
M
L
ST
Q
F
NRDNQ
H
QA
II
KPS
L
LAGCI
A
LAL
L
P
S
A
A
F
A
A
P
ATE
ETVIV
EG
SA
T
---
AP
D
D
GEN
DY
N
V
T
ST
------
SAGTKMQM
T
QR
DIPQSVT
I
VS
Q
Q
R
ME
D
QQ
LQ
TL
G
EV
M
E
NT
L
G
I
---
-
-
S
K
S
Q
A
D
S
D
R
A
LYY
SRGF
------
QI
DNYM
--
V
DGI
P
T
YFESR
WNLGDA
LS
DM
-
AL
F
ERVEVVRG
A
T
G
L
M
T
G
TG
NP
SA
AINMV
R
K
H
AT
SRE
------------
FKGDVSAEYGS
W
NK
ER
Y
VA
D
L
Q
SP
L
TE
DG
KIR
ARIVG
GY
QN
N
D
S
W
LDRYN
SE
K
TF
------
FSG
IV
D
A
DL
G
DL
T
M
LSAG
YEY
Q
RIDVNS
P
T
WGG
----
LP
RW
N
T
D
-----
GS
S
N
SYDR
AR
ST
AP
D
WAY
ND
K
EI
N
--------
K
V
FM
TLK
Q
R
FADTWQAT
L
N
AT
HSE
V
EFD
SKMMY
V
D
AY
VNKADGMLVGPYSNYGPGF
DY
V
G
GTG
WN
S
G
---------------------------
-
-
K
R
K
VDA
-------
--
-
--
-
-
---
-
L
D
LF
A
DG
SY
EL
FGR
QH
N
LMFGG
----------
SYSK
QN
N
RYFSSWANIFPD
EI
GSF
Y
N
FN
GN
F
P
QT
D
-
-
--
W
SP
-------------
----
---
------------QS
L
A
QDD
T
TH
M
KS
L
YAA
T
RVT
L
A
D
PLHLI
LG
A
R
-------
Y
----
--
-TNW
R
--------------
VDTLTY
-----
SM
EK
N
HT
----
TP
YA
GLVF
D
I
N
DNWS
T
YASYT
S
I
FQP
---------
Q
N
-
DR
D
SS
G
KY
-
L
T
P
I
TGNNYE
-------
LGLK
SDWM
N
SR
LT
T
T
L
AIF
R
I
E
Q
D
NVA
Q
S
---
T
GT
P
I
PGSN
GE
T
AYKAVDGTV
SKGVE
F
ELN
---
GA
I
T
D
NWQL
TF
GA
T
R
Y
I
AE
DN
-------
E
G
N
A
VN
PNLP
-----
RTTVKMF
T
SY
R
L
P
VMP
E
---
LT
V
G
-----
GGV
N
W
QN
--
R
VY
TDT
VT
PY
G
-
TFR
A
EQ
GSYALVDLFTRY
Q
VTK
----
NF
SLQGNVNNLFDKTY
D
TN
VE
GSIVY
-
--
-
GAPR
N
F
SI
TGTYQF
fig|679207.4.peg.1816
Escherichia coli MS 107-1
M
L
ST
Q
F
NRDNQ
Y
QA
IT
KPS
L
LAGCI
A
LAL
L
P
S
A
A
F
A
A
P
ATE
ETVIV
EG
SA
T
---
AP
D
D
GEN
DY
S
V
T
ST
------
SAGTKMQM
T
QR
DIPQSVT
I
VS
Q
Q
R
ME
D
QQ
LQ
TL
G
EV
M
E
NT
Q
G
I
---
-
-
S
K
S
Q
A
D
S
D
R
A
LYY
SRGF
------
QI
DNYM
--
V
DGI
P
T
YFESR
WNLGDA
LS
DM
-
AL
F
ERVEVVRG
A
T
G
L
M
T
G
TG
NP
SA
AINMV
R
K
H
AT
SRE
------------
FKGDVSAEYGS
W
NK
ER
Y
VA
D
L
Q
SP
L
TE
DG
KIR
ARIVG
GY
QN
N
D
S
W
LDRYN
SE
K
TF
------
FSG
IV
D
A
DL
G
DL
T
T
LSAG
YEY
Q
RIDVNS
P
T
WGG
----
LP
RW
N
T
D
-----
GS
S
N
SYDR
AR
ST
AP
D
WAY
ND
K
EI
N
--------
K
V
FM
TLK
Q
R
FADTWQAT
L
N
AT
HSE
V
EFD
SKMMY
V
D
AY
VNKADGMLVGPYSNYGPGF
DY
V
G
GTG
WN
S
G
---------------------------
-
-
K
R
K
VDA
-------
--
-
--
-
-
---
-
L
D
LF
A
DG
SY
EL
FGR
QH
N
LMFGG
----------
SYSK
QN
N
RYFSSW
T
NIFPD
EI
GSF
Y
N
FN
GN
F
P
QT
D
-
-
--
W
SP
-------------
----
---
------------QS
L
A
QDD
T
TH
M
KS
L
YAA
T
RVT
L
A
D
PLHLI
LG
A
R
-------
Y
----
--
-TNW
R
--------------
VDTLTY
-----
SM
EK
N
HT
----
TP
YA
GLVF
D
I
N
DNWS
T
YASYT
S
I
FQP
---------
Q
N
-
DR
D
SS
G
KY
-
L
A
P
I
TGNNYE
-------
LGLK
SDWM
N
SR
LT
T
T
L
AIF
R
I
E
Q
D
NVA
Q
S
---
T
GT
P
I
PGSN
GE
T
AYKAVDGTV
SKGVE
F
ELN
---
GA
I
T
D
NWQL
TF
GA
T
R
Y
I
AE
DN
-------
E
G
N
A
VN
PNLP
-----
RTTVKMF
T
SY
R
L
P
VMP
E
---
LT
V
G
-----
GGV
N
W
QN
--
R
VY
TDT
VT
PY
G
-
TFR
A
EQ
GSYALVDLFTRY
Q
VTK
----
NF
SLQGNVNNLFDKTY
D
TN
VE
GSIVY
-
--
-
GAPR
N
F
SI
TGTYQF
fig|525281.3.peg.374
Escherichia coli 83972
M
L
ST
Q
F
NRDNQ
H
QA
II
KPS
L
LAGCI
A
LAL
L
P
S
A
A
F
A
A
P
VTE
ETVIV
EG
SA
T
---
AP
D
D
GEN
DY
N
V
T
ST
------
SAGTKMQM
T
QR
DIPQSVT
I
VS
Q
Q
R
ME
D
QQ
LQ
TL
G
EV
M
E
NT
L
G
I
---
-
-
S
K
S
Q
A
D
S
D
R
A
LYY
SRGF
------
QI
DNYM
--
V
DGI
P
T
YFESR
WNLGDA
LS
DM
-
AL
F
ERVEVVRG
A
T
G
L
M
T
G
TG
NP
SA
AINMV
R
K
H
AT
SRE
------------
FKGDVSAEYGS
W
NK
ER
Y
VA
D
L
Q
SP
L
TE
DG
KIR
ARIVG
GY
QN
N
D
S
W
LDRYN
SE
K
TF
------
FSG
IV
D
A
DL
G
DL
T
M
LSAG
YEY
Q
RIDVNS
P
T
WGG
----
LP
RW
N
T
D
-----
GS
S
N
SYDR
AR
ST
AP
D
WAY
ND
K
EI
N
--------
K
V
FM
TLK
Q
R
FADTWQAT
L
N
AT
HSE
V
EFD
SKMMY
V
D
AY
VNKADGMLVGPYSNYGPGF
DY
V
G
GTG
WN
S
G
---------------------------
-
-
K
R
K
VDA
-------
--
-
--
-
-
---
-
L
D
LF
A
DG
SY
EL
FGR
QH
N
LMFGG
----------
SYSK
QN
N
RYFSSWANIFPD
EI
GSF
Y
N
FN
GN
F
P
QT
D
-
-
--
W
SP
-------------
----
---
------------QS
L
A
QDD
T
TH
M
KS
L
YAA
T
RVT
L
A
D
PLHLI
LG
A
R
-------
Y
----
--
-TNW
R
--------------
VDTLTY
-----
SM
EK
N
HT
----
TP
YA
GLVF
D
I
N
DNWS
T
YASYT
S
I
FQP
---------
Q
N
-
DR
D
SS
G
KY
-
L
T
P
I
TGNNYE
-------
LGLK
SDWM
N
SR
LT
T
T
L
AIF
R
I
E
Q
D
NVA
Q
S
---
T
GT
P
I
PGSN
GE
T
AYKAVDGTV
SKGVE
F
ELN
---
GA
I
T
D
NWQL
TF
GA
T
R
Y
I
AE
DN
-------
E
G
N
A
VN
PNLP
-----
RTTVKMF
T
SY
R
L
P
VMP
E
---
LT
V
G
-----
GGV
N
W
QN
--
R
VY
TDT
VT
PY
G
-
TFR
A
EQ
GSYALVDLFTRY
Q
VTK
----
NF
SLQGNVNNLFDKTY
D
TN
VE
GSIVY
-
--
-
GAPR
N
F
SI
TGTYQF
fig|655817.3.peg.1389
Escherichia coli ABU 83972
M
L
ST
Q
F
NRDNQ
H
QA
II
KPS
L
LAGCI
A
LAL
L
P
S
A
A
F
A
A
P
VTE
ETVIV
EG
SA
T
---
AP
D
D
GEN
DY
N
V
T
ST
------
SAGTKMQM
T
QR
DIPQSVT
I
VS
Q
Q
R
ME
D
QQ
LQ
TL
G
EV
M
E
NT
L
G
I
---
-
-
S
K
S
Q
A
D
S
D
R
A
LYY
SRGF
------
QI
DNYM
--
V
DGI
P
T
YFESR
WNLGDA
LS
DM
-
AL
F
ERVEVVRG
A
T
G
L
M
T
G
TG
NP
SA
AINMV
R
K
H
AT
SRE
------------
FKGDVSAEYGS
W
NK
ER
Y
VA
D
L
Q
SP
L
TE
DG
KIR
ARIVG
GY
QN
N
D
S
W
LDRYN
SE
K
TF
------
FSG
IV
D
A
DL
G
DL
T
M
LSAG
YEY
Q
RIDVNS
P
T
WGG
----
LP
RW
N
T
D
-----
GS
S
N
SYDR
AR
ST
AP
D
WAY
ND
K
EI
N
--------
K
V
FM
TLK
Q
R
FADTWQAT
L
N
AT
HSE
V
EFD
SKMMY
V
D
AY
VNKADGMLVGPYSNYGPGF
DY
V
G
GTG
WN
S
G
---------------------------
-
-
K
R
K
VDA
-------
--
-
--
-
-
---
-
L
D
LF
A
DG
SY
EL
FGR
QH
N
LMFGG
----------
SYSK
QN
N
RYFSSWANIFPD
EI
GSF
Y
N
FN
GN
F
P
QT
D
-
-
--
W
SP
-------------
----
---
------------QS
L
A
QDD
T
TH
M
KS
L
YAA
T
RVT
L
A
D
PLHLI
LG
A
R
-------
Y
----
--
-TNW
R
--------------
VDTLTY
-----
SM
EK
N
HT
----
TP
YA
GLVF
D
I
N
DNWS
T
YASYT
S
I
FQP
---------
Q
N
-
DR
D
SS
G
KY
-
L
T
P
I
TGNNYE
-------
LGLK
SDWM
N
SR
LT
T
T
L
AIF
R
I
E
Q
D
NVA
Q
S
---
T
GT
P
I
PGSN
GE
T
AYKAVDGTV
SKGVE
F
ELN
---
GA
I
T
D
NWQL
TF
GA
T
R
Y
I
AE
DN
-------
E
G
N
A
VN
PNLP
-----
RTTVKMF
T
SY
R
L
P
VMP
E
---
LT
V
G
-----
GGV
N
W
QN
--
R
VY
TDT
VT
PY
G
-
TFR
A
EQ
GSYALVDLFTRY
Q
VTK
----
NF
SLQGNVNNLFDKTY
D
TN
VE
GSIVY
-
--
-
GAPR
N
F
SI
TGTYQF
fig|405955.13.peg.1105
Escherichia coli APEC O1
M
L
ST
Q
F
NRDNQ
H
QA
II
KPS
L
LAGCI
A
LAL
L
P
S
A
A
F
A
A
P
VTE
ETVIV
EG
SA
T
---
AP
D
D
GEN
DY
N
V
T
ST
------
SAGTKMQM
T
QR
DIPQSVT
I
VS
Q
Q
R
ME
D
QQ
LQ
TL
G
EV
M
E
NT
L
G
I
---
-
-
S
K
S
Q
A
D
S
D
R
A
LYY
SRGF
------
QI
DNYM
--
V
DGI
P
T
YFESR
WNLGDA
LS
DM
-
AL
F
ERVEVVRG
A
T
G
L
M
T
G
TG
NP
SA
AINMV
R
K
H
AT
SRE
------------
FKGDVSAEYGS
W
NK
ER
Y
VA
D
L
Q
SP
L
TE
DG
KIR
ARIVG
GY
QN
N
D
S
W
LDRYN
SE
K
TF
------
FSG
IV
D
A
DL
G
DL
T
M
LSAG
YEY
Q
RIDVNS
P
T
WGG
----
LP
RW
N
T
D
-----
GS
S
N
SYDR
AR
ST
AP
D
WAY
ND
K
EI
N
--------
K
V
FM
TLK
Q
R
FADTWQAT
L
N
AT
HSE
V
EFD
SKMMY
V
D
AY
VNKADGMLVGPYSNYGPGF
DY
V
G
GTG
WN
S
G
---------------------------
-
-
K
R
K
VDA
-------
--
-
--
-
-
---
-
L
D
LF
A
DG
SY
EL
FGR
QH
N
LMFGG
----------
SYSK
QN
N
RYFSSWANIFPD
EI
GSF
Y
N
FN
GN
F
P
QT
D
-
-
--
W
SP
-------------
----
---
------------QS
L
A
QDD
T
TH
M
KS
L
YAA
T
RVT
L
A
D
PLHLI
LG
A
R
-------
Y
----
--
-TNW
R
--------------
VDTLTY
-----
SM
EK
N
HT
----
TP
YA
GLVF
D
I
N
DNWS
T
YASYT
S
I
FQP
---------
Q
N
-
DR
D
SS
G
KY
-
L
T
P
I
TGNNYE
-------
LGLK
SDWM
N
SR
LT
T
T
L
AIF
R
I
E
Q
D
NVA
Q
S
---
T
GT
P
I
PGSN
GE
T
AYKAVDGTV
SKGVE
F
ELN
---
GA
I
T
D
NWQL
TF
GA
T
R
Y
I
AE
DN
-------
E
G
N
A
VN
PNLP
-----
RTTVKMF
T
SY
R
L
P
VMP
E
---
LT
V
G
-----
GGV
N
W
QN
--
R
VY
TDT
VT
PY
G
-
TFR
A
EQ
GSYALVDLFTRY
Q
VTK
----
NF
SLQGNVNNLFDKTY
D
TN
VE
GSIVY
-
--
-
GAPR
N
F
SI
TGTYQF
fig|405955.9.peg.929
Escherichia coli APEC O1
M
L
ST
Q
F
NRDNQ
H
QA
II
KPS
L
LAGCI
A
LAL
L
P
S
A
A
F
A
A
P
VTE
ETVIV
EG
SA
T
---
AP
D
D
GEN
DY
N
V
T
ST
------
SAGTKMQM
T
QR
DIPQSVT
I
VS
Q
Q
R
ME
D
QQ
LQ
TL
G
EV
M
E
NT
L
G
I
---
-
-
S
K
S
Q
A
D
S
D
R
A
LYY
SRGF
------
QI
DNYM
--
V
DGI
P
T
YFESR
WNLGDA
LS
DM
-
AL
F
ERVEVVRG
A
T
G
L
M
T
G
TG
NP
SA
AINMV
R
K
H
AT
SRE
------------
FKGDVSAEYGS
W
NK
ER
Y
VA
D
L
Q
SP
L
TE
DG
KIR
ARIVG
GY
QN
N
D
S
W
LDRYN
SE
K
TF
------
FSG
IV
D
A
DL
G
DL
T
M
LSAG
YEY
Q
RIDVNS
P
T
WGG
----
LP
RW
N
T
D
-----
GS
S
N
SYDR
AR
ST
AP
D
WAY
ND
K
EI
N
--------
K
V
FM
TLK
Q
R
FADTWQAT
L
N
AT
HSE
V
EFD
SKMMY
V
D
AY
VNKADGMLVGPYSNYGPGF
DY
V
G
GTG
WN
S
G
---------------------------
-
-
K
R
K
VDA
-------
--
-
--
-
-
---
-
L
D
LF
A
DG
SY
EL
FGR
QH
N
LMFGG
----------
SYSK
QN
N
RYFSSWANIFPD
EI
GSF
Y
N
FN
GN
F
P
QT
D
-
-
--
W
SP
-------------
----
---
------------QS
L
A
QDD
T
TH
M
KS
L
YAA
T
RVT
L
A
D
PLHLI
LG
A
R
-------
Y
----
--
-TNW
R
--------------
VDTLTY
-----
SM
EK
N
HT
----
TP
YA
GLVF
D
I
N
DNWS
T
YASYT
S
I
FQP
---------
Q
N
-
DR
D
SS
G
KY
-
L
T
P
I
TGNNYE
-------
LGLK
SDWM
N
SR
LT
T
T
L
AIF
R
I
E
Q
D
NVA
Q
S
---
T
GT
P
I
PGSN
GE
T
AYKAVDGTV
SKGVE
F
ELN
---
GA
I
T
D
NWQL
TF
GA
T
R
Y
I
AE
DN
-------
E
G
N
A
VN
PNLP
-----
RTTVKMF
T
SY
R
L
P
VMP
E
---
LT
V
G
-----
GGV
N
W
QN
--
R
VY
TDT
VT
PY
G
-
TFR
A
EQ
GSYALVDLFTRY
Q
VTK
----
NF
SLQGNVNNLFDKTY
D
TN
VE
GSIVY
-
--
-
GAPR
N
F
SI
TGTYQF
fig|199310.1.peg.1327
Escherichia coli CFT073
M
L
ST
Q
F
NRDNQ
H
QA
II
KPS
L
LAGCI
A
LAL
L
P
S
A
A
F
A
A
P
VTE
ETVIV
EG
SA
T
---
AP
D
D
GEN
DY
N
V
T
ST
------
SAGTKMQM
T
QR
DIPQSVT
I
VS
Q
Q
R
ME
D
QQ
LQ
TL
G
EV
M
E
NT
L
G
I
---
-
-
S
K
S
Q
A
D
S
D
R
A
LYY
SRGF
------
QI
DNYM
--
V
DGI
P
T
YFESR
WNLGDA
LS
DM
-
AL
F
ERVEVVRG
A
T
G
L
M
T
G
TG
NP
SA
AINMV
R
K
H
AT
SRE
------------
FKGDVSAEYGS
W
NK
ER
Y
VA
D
L
Q
SP
L
TE
DG
KIR
ARIVG
GY
QN
N
D
S
W
LDRYN
SE
K
TF
------
FSG
IV
D
A
DL
G
DL
T
M
LSAG
YEY
Q
RIDVNS
P
T
WGG
----
LP
RW
N
T
D
-----
GS
S
N
SYDR
AR
ST
AP
D
WAY
ND
K
EI
N
--------
K
V
FM
TLK
Q
R
FADTWQAT
L
N
AT
HSE
V
EFD
SKMMY
V
D
AY
VNKADGMLVGPYSNYGPGF
DY
V
G
GTG
WN
S
G
---------------------------
-
-
K
R
K
VDA
-------
--
-
--
-
-
---
-
L
D
LF
A
DG
SY
EL
FGR
QH
N
LMFGG
----------
SYSK
QN
N
RYFSSWANIFPD
EI
GSF
Y
N
FN
GN
F
P
QT
D
-
-
--
W
SP
-------------
----
---
------------QS
L
A
QDD
T
TH
M
KS
L
YAA
T
RVT
L
A
D
PLHLI
LG
A
R
-------
Y
----
--
-TNW
R
--------------
VDTLTY
-----
SM
EK
N
HT
----
TP
YA
GLVF
D
I
N
DNWS
T
YASYT
S
I
FQP
---------
Q
N
-
DR
D
SS
G
KY
-
L
T
P
I
TGNNYE
-------
LGLK
SDWM
N
SR
LT
T
T
L
AIF
R
I
E
Q
D
NVA
Q
S
---
T
GT
P
I
PGSN
GE
T
AYKAVDGTV
SKGVE
F
ELN
---
GA
I
T
D
NWQL
TF
GA
T
R
Y
I
AE
DN
-------
E
G
N
A
VN
PNLP
-----
RTTVKMF
T
SY
R
L
P
VMP
E
---
LT
V
G
-----
GGV
N
W
QN
--
R
VY
TDT
VT
PY
G
-
TFR
A
EQ
GSYALVDLFTRY
Q
VTK
----
NF
SLQGNVNNLFDKTY
D
TN
VE
GSIVY
-
--
-
GAPR
N
F
SI
TGTYQF
fig|199310.4.peg.1303
Escherichia coli CFT073
M
L
ST
Q
F
NRDNQ
H
QA
II
KPS
L
LAGCI
A
LAL
L
P
S
A
A
F
A
A
P
VTE
ETVIV
EG
SA
T
---
AP
D
D
GEN
DY
N
V
T
ST
------
SAGTKMQM
T
QR
DIPQSVT
I
VS
Q
Q
R
ME
D
QQ
LQ
TL
G
EV
M
E
NT
L
G
I
---
-
-
S
K
S
Q
A
D
S
D
R
A
LYY
SRGF
------
QI
DNYM
--
V
DGI
P
T
YFESR
WNLGDA
LS
DM
-
AL
F
ERVEVVRG
A
T
G
L
M
T
G
TG
NP
SA
AINMV
R
K
H
AT
SRE
------------
FKGDVSAEYGS
W
NK
ER
Y
VA
D
L
Q
SP
L
TE
DG
KIR
ARIVG
GY
QN
N
D
S
W
LDRYN
SE
K
TF
------
FSG
IV
D
A
DL
G
DL
T
M
LSAG
YEY
Q
RIDVNS
P
T
WGG
----
LP
RW
N
T
D
-----
GS
S
N
SYDR
AR
ST
AP
D
WAY
ND
K
EI
N
--------
K
V
FM
TLK
Q
R
FADTWQAT
L
N
AT
HSE
V
EFD
SKMMY
V
D
AY
VNKADGMLVGPYSNYGPGF
DY
V
G
GTG
WN
S
G
---------------------------
-
-
K
R
K
VDA
-------
--
-
--
-
-
---
-
L
D
LF
A
DG
SY
EL
FGR
QH
N
LMFGG
----------
SYSK
QN
N
RYFSSWANIFPD
EI
GSF
Y
N
FN
GN
F
P
QT
D
-
-
--
W
SP
-------------
----
---
------------QS
L
A
QDD
T
TH
M
KS
L
YAA
T
RVT
L
A
D
PLHLI
LG
A
R
-------
Y
----
--
-TNW
R
--------------
VDTLTY
-----
SM
EK
N
HT
----
TP
YA
GLVF
D
I
N
DNWS
T
YASYT
S
I
FQP
---------
Q
N
-
DR
D
SS
G
KY
-
L
T
P
I
TGNNYE
-------
LGLK
SDWM
N
SR
LT
T
T
L
AIF
R
I
E
Q
D
NVA
Q
S
---
T
GT
P
I
PGSN
GE
T
AYKAVDGTV
SKGVE
F
ELN
---
GA
I
T
D
NWQL
TF
GA
T
R
Y
I
AE
DN
-------
E
G
N
A
VN
PNLP
-----
RTTVKMF
T
SY
R
L
P
VMP
E
---
LT
V
G
-----
GGV
N
W
QN
--
R
VY
TDT
VT
PY
G
-
TFR
A
EQ
GSYALVDLFTRY
Q
VTK
----
NF
SLQGNVNNLFDKTY
D
TN
VE
GSIVY
-
--
-
GAPR
N
F
SI
TGTYQF
fig|714962.3.peg.1232
Escherichia coli IHE3034
M
L
ST
Q
F
NRDNQ
H
QA
II
KPS
L
LAGCI
A
LAL
L
P
S
A
A
F
A
A
P
VTE
ETVIV
EG
SA
T
---
AP
D
D
GEN
DY
N
V
T
ST
------
SAGTKMQM
T
QR
DIPQSVT
I
VS
Q
Q
R
ME
D
QQ
LQ
TL
G
EV
M
E
NT
L
G
I
---
-
-
S
K
S
Q
A
D
S
D
R
A
LYY
SRGF
------
QI
DNYM
--
V
DGI
P
T
YFESR
WNLGDA
LS
DM
-
AL
F
ERVEVVRG
A
T
G
L
M
T
G
TG
NP
SA
AINMV
R
K
H
AT
SRE
------------
FKGDVSAEYGS
W
NK
ER
Y
VA
D
L
Q
SP
L
TE
DG
KIR
ARIVG
GY
QN
N
D
S
W
LDRYN
SE
K
TF
------
FSG
IV
D
A
DL
G
DL
T
M
LSAG
YEY
Q
RIDVNS
P
T
WGG
----
LP
RW
N
T
D
-----
GS
S
N
SYDR
AR
ST
AP
D
WAY
ND
K
EI
N
--------
K
V
FM
TLK
Q
R
FADTWQAT
L
N
AT
HSE
V
EFD
SKMMY
V
D
AY
VNKADGMLVGPYSNYGPGF
DY
V
G
GTG
WN
S
G
---------------------------
-
-
K
R
K
VDA
-------
--
-
--
-
-
---
-
L
D
LF
A
DG
SY
EL
FGR
QH
N
LMFGG
----------
SYSK
QN
N
RYFSSWANIFPD
EI
GSF
Y
N
FN
GN
F
P
QT
D
-
-
--
W
SP
-------------
----
---
------------QS
L
A
QDD
T
TH
M
KS
L
YAA
T
RVT
L
A
D
PLHLI
LG
A
R
-------
Y
----
--
-TNW
R
--------------
VDTLTY
-----
SM
EK
N
HT
----
TP
YA
GLVF
D
I
N
DNWS
T
YASYT
S
I
FQP
---------
Q
N
-
DR
D
SS
G
KY
-
L
T
P
I
TGNNYE
-------
LGLK
SDWM
N
SR
LT
T
T
L
AIF
R
I
E
Q
D
NVA
Q
S
---
T
GT
P
I
PGSN
GE
T
AYKAVDGTV
SKGVE
F
ELN
---
GA
I
T
D
NWQL
TF
GA
T
R
Y
I
AE
DN
-------
E
G
N
A
VN
PNLP
-----
RTTVKMF
T
SY
R
L
P
VMP
E
---
LT
V
G
-----
GGV
N
W
QN
--
R
VY
TDT
VT
PY
G
-
TFR
A
EQ
GSYALVDLFTRY
Q
VTK
----
NF
SLQGNVNNLFDKTY
D
TN
VE
GSIVY
-
--
-
GAPR
N
F
SI
TGTYQF
fig|749546.3.peg.4794
Escherichia coli MS 185-1
M
L
ST
Q
F
NRDNQ
H
QA
II
KPS
L
LAGCI
A
LAL
L
P
S
A
A
F
A
A
P
VTE
ETVIV
EG
SA
T
---
AP
D
D
GEN
DY
N
V
T
ST
------
SAGTKMQM
T
QR
DIPQSVT
I
VS
Q
Q
R
ME
D
QQ
LQ
TL
G
EV
M
E
NT
L
G
I
---
-
-
S
K
S
Q
A
D
S
D
R
A
LYY
SRGF
------
QI
DNYM
--
V
DGI
P
T
YFESR
WNLGDA
LS
DM
-
AL
F
ERVEVVRG
A
T
G
L
M
T
G
TG
NP
SA
AINMV
R
K
H
AT
SRE
------------
FKGDVSAEYGS
W
NK
ER
Y
VA
D
L
Q
SP
L
TE
DG
KIR
ARIVG
GY
QN
N
D
S
W
LDRYN
SE
K
TF
------
FSG
IV
D
A
DL
G
DL
T
M
LSAG
YEY
Q
RIDVNS
P
T
WGG
----
LP
RW
N
T
D
-----
GS
S
N
SYDR
AR
ST
AP
D
WAY
ND
K
EI
N
--------
K
V
FM
TLK
Q
R
FADTWQAT
L
N
AT
HSE
V
EFD
SKMMY
V
D
AY
VNKADGMLVGPYSNYGPGF
DY
V
G
GTG
WN
S
G
---------------------------
-
-
K
R
K
VDA
-------
--
-
--
-
-
---
-
L
D
LF
A
DG
SY
EL
FGR
QH
N
LMFGG
----------
SYSK
QN
N
RYFSSWANIFPD
EI
GSF
Y
N
FN
GN
F
P
QT
D
-
-
--
W
SP
-------------
----
---
------------QS
L
A
QDD
T
TH
M
KS
L
YAA
T
RVT
L
A
D
PLHLI
LG
A
R
-------
Y
----
--
-TNW
R
--------------
VDTLTY
-----
SM
EK
N
HT
----
TP
YA
GLVF
D
I
N
DNWS
T
YASYT
S
I
FQP
---------
Q
N
-
DR
D
SS
G
KY
-
L
T
P
I
TGNNYE
-------
LGLK
SDWM
N
SR
LT
T
T
L
AIF
R
I
E
Q
D
NVA
Q
S
---
T
GT
P
I
PGSN
GE
T
AYKAVDGTV
SKGVE
F
ELN
---
GA
I
T
D
NWQL
TF
GA
T
R
Y
I
AE
DN
-------
E
G
N
A
VN
PNLP
-----
RTTVKMF
T
SY
R
L
P
VMP
E
---
LT
V
G
-----
GGV
N
W
QN
--
R
VY
TDT
VT
PY
G
-
TFR
A
EQ
GSYALVDLFTRY
Q
VTK
----
NF
SLQGNVNNLFDKTY
D
TN
VE
GSIVY
-
--
-
GAPR
N
F
SI
TGTYQF
fig|749528.3.peg.745
Escherichia coli MS 45-1
M
L
ST
Q
F
NRDNQ
H
QA
II
KPS
L
LAGCI
A
LAL
L
P
S
A
A
F
A
A
P
VTE
ETVIV
EG
SA
T
---
AP
D
D
GEN
DY
N
V
T
ST
------
SAGTKMQM
T
QR
DIPQSVT
I
VS
Q
Q
R
ME
D
QQ
LQ
TL
G
EV
M
E
NT
L
G
I
---
-
-
S
K
S
Q
A
D
S
D
R
A
LYY
SRGF
------
QI
DNYM
--
V
DGI
P
T
YFESR
WNLGDA
LS
DM
-
AL
F
ERVEVVRG
A
T
G
L
M
T
G
TG
NP
SA
AINMV
R
K
H
AT
SRE
------------
FKGDVSAEYGS
W
NK
ER
Y
VA
D
L
Q
SP
L
TE
DG
KIR
ARIVG
GY
QN
N
D
S
W
LDRYN
SE
K
TF
------
FSG
IV
D
A
DL
G
DL
T
M
LSAG
YEY
Q
RIDVNS
P
T
WGG
----
LP
RW
N
T
D
-----
GS
S
N
SYDR
AR
ST
AP
D
WAY
ND
K
EI
N
--------
K
V
FM
TLK
Q
R
FADTWQAT
L
N
AT
HSE
V
EFD
SKMMY
V
D
AY
VNKADGMLVGPYSNYGPGF
DY
V
G
GTG
WN
S
G
---------------------------
-
-
K
R
K
VDA
-------
--
-
--
-
-
---
-
L
D
LF
A
DG
SY
EL
FGR
QH
N
LMFGG
----------
SYSK
QN
N
RYFSSWANIFPD
EI
GSF
Y
N
FN
GN
F
P
QT
D
-
-
--
W
SP
-------------
----
---
------------QS
L
A
QDD
T
TH
M
KS
L
YAA
T
RVT
L
A
D
PLHLI
LG
A
R
-------
Y
----
--
-TNW
R
--------------
VDTLTY
-----
SM
EK
N
HT
----
TP
YA
GLVF
D
I
N
DNWS
T
YASYT
S
I
FQP
---------
Q
N
-
DR
D
SS
G
KY
-
L
T
P
I
TGNNYE
-------
LGLK
SDWM
N
SR
LT
T
T
L
AIF
R
I
E
Q
D
NVA
Q
S
---
T
GT
P
I
PGSN
GE
T
AYKAVDGTV
SKGVE
F
ELN
---
GA
I
T
D
NWQL
TF
GA
T
R
Y
I
AE
DN
-------
E
G
N
A
VN
PNLP
-----
RTTVKMF
T
SY
R
L
P
VMP
E
---
LT
V
G
-----
GGV
N
W
QN
--
R
VY
TDT
VT
PY
G
-
TFR
A
EQ
GSYALVDLFTRY
Q
VTK
----
NF
SLQGNVNNLFDKTY
D
TN
VE
GSIVY
-
--
-
GAPR
N
F
SI
TGTYQF
fig|585035.6.peg.1122
Escherichia coli S88
M
L
ST
Q
F
NRDNQ
H
QA
II
KPS
L
LAGCI
A
LAL
L
P
S
A
A
F
A
A
P
VTE
ETVIV
EG
SA
T
---
AP
D
D
GEN
DY
N
V
T
ST
------
SAGTKMQM
T
QR
DIPQSVT
I
VS
Q
Q
R
ME
D
QQ
LQ
TL
G
EV
M
E
NT
L
G
I
---
-
-
S
K
S
Q
A
D
S
D
R
A
LYY
SRGF
------
QI
DNYM
--
V
DGI
P
T
YFESR
WNLGDA
LS
DM
-
AL
F
ERVEVVRG
A
T
G
L
M
T
G
TG
NP
SA
AINMV
R
K
H
AT
SRE
------------
FKGDVSAEYGS
W
NK
ER
Y
VA
D
L
Q
SP
L
TE
DG
KIR
ARIVG
GY
QN
N
D
S
W
LDRYN
SE
K
TF
------
FSG
IV
D
A
DL
G
DL
T
M
LSAG
YEY
Q
RIDVNS
P
T
WGG
----
LP
RW
N
T
D
-----
GS
S
N
SYDR
AR
ST
AP
D
WAY
ND
K
EI
N
--------
K
V
FM
TLK
Q
R
FADTWQAT
L
N
AT
HSE
V
EFD
SKMMY
V
D
AY
VNKADGMLVGPYSNYGPGF
DY
V
G
GTG
WN
S
G
---------------------------
-
-
K
R
K
VDA
-------
--
-
--
-
-
---
-
L
D
LF
A
DG
SY
EL
FGR
QH
N
LMFGG
----------
SYSK
QN
N
RYFSSWANIFPD
EI
GSF
Y
N
FN
GN
F
P
QT
D
-
-
--
W
SP
-------------
----
---
------------QS
L
A
QDD
T
TH
M
KS
L
YAA
T
RVT
L
A
D
PLHLI
LG
A
R
-------
Y
----
--
-TNW
R
--------------
VDTLTY
-----
SM
EK
N
HT
----
TP
YA
GLVF
D
I
N
DNWS
T
YASYT
S
I
FQP
---------
Q
N
-
DR
D
SS
G
KY
-
L
T
P
I
TGNNYE
-------
LGLK
SDWM
N
SR
LT
T
T
L
AIF
R
I
E
Q
D
NVA
Q
S
---
T
GT
P
I
PGSN
GE
T
AYKAVDGTV
SKGVE
F
ELN
---
GA
I
T
D
NWQL
TF
GA
T
R
Y
I
AE
DN
-------
E
G
N
A
VN
PNLP
-----
RTTVKMF
T
SY
R
L
P
VMP
E
---
LT
V
G
-----
GGV
N
W
QN
--
R
VY
TDT
VT
PY
G
-
TFR
A
EQ
GSYALVDLFTRY
Q
VTK
----
NF
SLQGNVNNLFDKTY
D
TN
VE
GSIVY
-
--
-
GAPR
N
F
SI
TGTYQF
fig|869729.3.peg.2519
Escherichia coli UM146
M
L
ST
Q
F
NRDNQ
H
QA
II
KPS
L
LAGCI
A
LAL
L
P
S
A
A
F
A
A
P
VTE
ETVIV
EG
SA
T
---
AP
D
D
GEN
DY
N
V
T
ST
------
SAGTKMQM
T
QR
DIPQSVT
I
VS
Q
Q
R
ME
D
QQ
LQ
TL
G
EV
M
E
NT
L
G
I
---
-
-
S
K
S
Q
A
D
S
D
R
A
LYY
SRGF
------
QI
DNYM
--
V
DGI
P
T
YFESR
WNLGDA
LS
DM
-
AL
F
ERVEVVRG
A
T
G
L
M
T
G
TG
NP
SA
AINMV
R
K
H
AT
SRE
------------
FKGDVSAEYGS
W
NK
ER
Y
VA
D
L
Q
SP
L
TE
DG
KIR
ARIVG
GY
QN
N
D
S
W
LDRYN
SE
K
TF
------
FSG
IV
D
A
DL
G
DL
T
M
LSAG
YEY
Q
RIDVNS
P
T
WGG
----
LP
RW
N
T
D
-----
GS
S
N
SYDR
AR
ST
AP
D
WAY
ND
K
EI
N
--------
K
V
FM
TLK
Q
R
FADTWQAT
L
N
AT
HSE
V
EFD
SKMMY
V
D
AY
VNKADGMLVGPYSNYGPGF
DY
V
G
GTG
WN
S
G
---------------------------
-
-
K
R
K
VDA
-------
--
-
--
-
-
---
-
L
D
LF
A
DG
SY
EL
FGR
QH
N
LMFGG
----------
SYSK
QN
N
RYFSSWANIFPD
EI
GSF
Y
N
FN
GN
F
P
QT
D
-
-
--
W
SP
-------------
----
---
------------QS
L
A
QDD
T
TH
M
KS
L
YAA
T
RVT
L
A
D
PLHLI
LG
A
R
-------
Y
----
--
-TNW
R
--------------
VDTLTY
-----
SM
EK
N
HT
----
TP
YA
GLVF
D
I
N
DNWS
T
YASYT
S
I
FQP
---------
Q
N
-
DR
D
SS
G
KY
-
L
T
P
I
TGNNYE
-------
LGLK
SDWM
N
SR
LT
T
T
L
AIF
R
I
E
Q
D
NVA
Q
S
---
T
GT
P
I
PGSN
GE
T
AYKAVDGTV
SKGVE
F
ELN
---
GA
I
T
D
NWQL
TF
GA
T
R
Y
I
AE
DN
-------
E
G
N
A
VN
PNLP
-----
RTTVKMF
T
SY
R
L
P
VMP
E
---
LT
V
G
-----
GGV
N
W
QN
--
R
VY
TDT
VT
PY
G
-
TFR
A
EQ
GSYALVDLFTRY
Q
VTK
----
NF
SLQGNVNNLFDKTY
D
TN
VE
GSIVY
-
--
-
GAPR
N
F
SI
TGTYQF
fig|364106.7.peg.1305
Escherichia coli UTI89
M
L
ST
Q
F
NRDNQ
H
QA
II
KPS
L
LAGCI
A
LAL
L
P
S
A
A
F
A
A
P
VTE
ETVIV
EG
SA
T
---
AP
D
D
GEN
DY
N
V
T
ST
------
SAGTKMQM
T
QR
DIPQSVT
I
VS
Q
Q
R
ME
D
QQ
LQ
TL
G
EV
M
E
NT
L
G
I
---
-
-
S
K
S
Q
A
D
S
D
R
A
LYY
SRGF
------
QI
DNYM
--
V
DGI
P
T
YFESR
WNLGDA
LS
DM
-
AL
F
ERVEVVRG
A
T
G
L
M
T
G
TG
NP
SA
AINMV
R
K
H
AT
SRE
------------
FKGDVSAEYGS
W
NK
ER
Y
VA
D
L
Q
SP
L
TE
DG
KIR
ARIVG
GY
QN
N
D
S
W
LDRYN
SE
K
TF
------
FSG
IV
D
A
DL
G
DL
T
M
LSAG
YEY
Q
RIDVNS
P
T
WGG
----
LP
RW
N
T
D
-----
GS
S
N
SYDR
AR
ST
AP
D
WAY
ND
K
EI
N
--------
K
V
FM
TLK
Q
R
FADTWQAT
L
N
AT
HSE
V
EFD
SKMMY
V
D
AY
VNKADGMLVGPYSNYGPGF
DY
V
G
GTG
WN
S
G
---------------------------
-
-
K
R
K
VDA
-------
--
-
--
-
-
---
-
L
D
LF
A
DG
SY
EL
FGR
QH
N
LMFGG
----------
SYSK
QN
N
RYFSSWANIFPD
EI
GSF
Y
N
FN
GN
F
P
QT
D
-
-
--
W
SP
-------------
----
---
------------QS
L
A
QDD
T
TH
M
KS
L
YAA
T
RVT
L
A
D
PLHLI
LG
A
R
-------
Y
----
--
-TNW
R
--------------
VDTLTY
-----
SM
EK
N
HT
----
TP
YA
GLVF
D
I
N
DNWS
T
YASYT
S
I
FQP
---------
Q
N
-
DR
D
SS
G
KY
-
L
T
P
I
TGNNYE
-------
LGLK
SDWM
N
SR
LT
T
T
L
AIF
R
I
E
Q
D
NVA
Q
S
---
T
GT
P
I
PGSN
GE
T
AYKAVDGTV
SKGVE
F
ELN
---
GA
I
T
D
NWQL
TF
GA
T
R
Y
I
AE
DN
-------
E
G
N
A
VN
PNLP
-----
RTTVKMF
T
SY
R
L
P
VMP
E
---
LT
V
G
-----
GGV
N
W
QN
--
R
VY
TDT
VT
PY
G
-
TFR
A
EQ
GSYALVDLFTRY
Q
VTK
----
NF
SLQGNVNNLFDKTY
D
TN
VE
GSIVY
-
--
-
GAPR
N
F
SI
TGTYQF
fig|364106.8.peg.1304
Escherichia coli UTI89
M
L
ST
Q
F
NRDNQ
H
QA
II
KPS
L
LAGCI
A
LAL
L
P
S
A
A
F
A
A
P
VTE
ETVIV
EG
SA
T
---
AP
D
D
GEN
DY
N
V
T
ST
------
SAGTKMQM
T
QR
DIPQSVT
I
VS
Q
Q
R
ME
D
QQ
LQ
TL
G
EV
M
E
NT
L
G
I
---
-
-
S
K
S
Q
A
D
S
D
R
A
LYY
SRGF
------
QI
DNYM
--
V
DGI
P
T
YFESR
WNLGDA
LS
DM
-
AL
F
ERVEVVRG
A
T
G
L
M
T
G
TG
NP
SA
AINMV
R
K
H
AT
SRE
------------
FKGDVSAEYGS
W
NK
ER
Y
VA
D
L
Q
SP
L
TE
DG
KIR
ARIVG
GY
QN
N
D
S
W
LDRYN
SE
K
TF
------
FSG
IV
D
A
DL
G
DL
T
M
LSAG
YEY
Q
RIDVNS
P
T
WGG
----
LP
RW
N
T
D
-----
GS
S
N
SYDR
AR
ST
AP
D
WAY
ND
K
EI
N
--------
K
V
FM
TLK
Q
R
FADTWQAT
L
N
AT
HSE
V
EFD
SKMMY
V
D
AY
VNKADGMLVGPYSNYGPGF
DY
V
G
GTG
WN
S
G
---------------------------
-
-
K
R
K
VDA
-------
--
-
--
-
-
---
-
L
D
LF
A
DG
SY
EL
FGR
QH
N
LMFGG
----------
SYSK
QN
N
RYFSSWANIFPD
EI
GSF
Y
N
FN
GN
F
P
QT
D
-
-
--
W
SP
-------------
----
---
------------QS
L
A
QDD
T
TH
M
KS
L
YAA
T
RVT
L
A
D
PLHLI
LG
A
R
-------
Y
----
--
-TNW
R
--------------
VDTLTY
-----
SM
EK
N
HT
----
TP
YA
GLVF
D
I
N
DNWS
T
YASYT
S
I
FQP
---------
Q
N
-
DR
D
SS
G
KY
-
L
T
P
I
TGNNYE
-------
LGLK
SDWM
N
SR
LT
T
T
L
AIF
R
I
E
Q
D
NVA
Q
S
---
T
GT
P
I
PGSN
GE
T
AYKAVDGTV
SKGVE
F
ELN
---
GA
I
T
D
NWQL
TF
GA
T
R
Y
I
AE
DN
-------
E
G
N
A
VN
PNLP
-----
RTTVKMF
T
SY
R
L
P
VMP
E
---
LT
V
G
-----
GGV
N
W
QN
--
R
VY
TDT
VT
PY
G
-
TFR
A
EQ
GSYALVDLFTRY
Q
VTK
----
NF
SLQGNVNNLFDKTY
D
TN
VE
GSIVY
-
--
-
GAPR
N
F
SI
TGTYQF
fig|562.376.peg.89
Escherichia coli WV_060327
M
L
ST
Q
F
NRDNQ
H
QA
II
KPS
L
LAGCI
A
LAL
L
P
S
A
A
F
A
A
P
VTE
ETVIV
EG
SA
T
---
AP
D
D
GEN
DY
N
V
T
ST
------
SAGTKMQM
T
QR
DIPQSVT
I
VS
Q
Q
R
ME
D
QQ
LQ
TL
G
EV
M
E
NT
L
G
I
---
-
-
S
K
S
Q
A
D
S
D
R
A
LYY
SRGF
------
QI
DNYM
--
V
DGI
P
T
YFESR
WNLGDA
LS
DM
-
AL
F
ERVEVVRG
A
T
G
L
M
T
G
TG
NP
SA
AINMV
R
K
H
AT
SRE
------------
FKGDVSAEYGS
W
NK
ER
Y
VA
D
L
Q
SP
L
TE
DG
KIR
ARIVG
GY
QN
N
D
S
W
LDRYN
SE
K
TF
------
FSG
IV
D
A
DL
G
DL
T
M
LSAG
YEY
Q
RIDVNS
P
T
WGG
----
LP
RW
N
T
D
-----
GS
S
N
SYDR
AR
ST
AP
D
WAY
ND
K
EI
N
--------
K
V
FM
TLK
Q
R
FADTWQAT
L
N
AT
HSE
V
EFD
SKMMY
V
D
AY
VNKADGMLVGPYSNYGPGF
DY
V
G
GTG
WN
S
G
---------------------------
-
-
K
R
K
VDA
-------
--
-
--
-
-
---
-
L
D
LF
A
DG
SY
EL
FGR
QH
N
LMFGG
----------
SYSK
QN
N
RYFSSWANIFPD
EI
GSF
Y
N
FN
GN
F
P
QT
D
-
-
--
W
SP
-------------
----
---
------------QS
L
A
QDD
T
TH
M
KS
L
YAA
T
RVT
L
A
D
PLHLI
LG
A
R
-------
Y
----
--
-TNW
R
--------------
VDTLTY
-----
SM
EK
N
HT
----
TP
YA
GLVF
D
I
N
DNWS
T
YASYT
S
I
FQP
---------
Q
N
-
DR
D
SS
G
KY
-
L
T
P
I
TGNNYE
-------
LGLK
SDWM
N
SR
LT
T
T
L
AIF
R
I
E
Q
D
NVA
Q
S
---
T
GT
P
I
PGSN
GE
T
AYKAVDGTV
SKGVE
F
ELN
---
GA
I
T
D
NWQL
TF
GA
T
R
Y
I
AE
DN
-------
E
G
N
A
VN
PNLP
-----
RTTVKMF
T
SY
R
L
P
VMP
E
---
LT
V
G
-----
GGV
N
W
QN
--
R
VY
TDT
VT
PY
G
-
TFR
A
EQ
GSYALVDLFTRY
Q
VTK
----
NF
SLQGNVNNLFDKTY
D
TN
VE
GSIVY
-
--
-
GAPR
N
F
SI
TGTYQF
fig|585396.4.peg.1436
Escherichia coli O111:H- str. 11128
M
L
ST
Q
F
NRDNQ
Y
QA
ST
KPS
L
LAGCI
A
LAL
L
P
S
A
A
F
A
A
P
ATE
ETVIV
EG
SA
T
---
AP
D
D
GEN
DY
S
V
T
ST
------
SAGTKMQM
T
QR
DIPQSVT
I
VS
Q
Q
R
ME
D
QQ
LQ
TL
G
EV
M
E
NT
L
G
I
---
-
-
S
K
S
Q
A
D
S
D
R
A
LYY
SRGF
------
QI
DNYM
--
V
DGI
P
T
YFESR
WNLGDA
LS
DM
-
AL
F
ERVEVVRG
A
T
G
L
M
T
G
TG
NP
SA
AINMV
R
K
H
AT
SRE
------------
FKGDVSAEYGS
W
NK
ER
Y
VA
D
L
Q
SP
L
TE
DG
KIR
ARIVG
GY
QN
N
D
S
W
LDRYN
SE
K
TF
------
FSG
IV
D
A
DL
G
DL
T
T
LSAG
YEY
Q
H
IDVNS
P
T
WGG
----
LP
RW
N
T
D
-----
GS
S
N
SYDR
AR
ST
AP
D
WAY
ND
K
EI
N
--------
K
V
FM
TLK
Q
R
FADTWQAT
L
N
AT
HSE
V
EFD
SKMMY
V
D
AY
VNKADGML
I
GPYSNYGPGF
DY
V
G
GTG
WN
S
G
---------------------------
-
-
K
R
K
VDA
-------
--
-
--
-
-
---
-
L
D
LF
A
DG
SY
EL
FGR
QH
N
LMFGG
----------
SYSK
QN
N
RYFSSWANIFPD
EI
GSF
Y
N
FN
GN
F
P
QT
D
-
-
--
W
SP
-------------
----
---
------------QS
L
A
QDD
T
TH
M
KS
L
YAA
T
RVT
L
A
D
PLHLI
LG
A
R
-------
Y
----
--
-TNW
R
--------------
VDTLTY
-----
SM
EK
N
HT
----
TP
YA
GLVF
D
I
N
DNWS
T
YASYT
S
I
FQP
---------
Q
N
-
DR
D
SS
G
KY
-
L
A
P
I
TGNNYE
-------
LGLK
SDWM
N
SR
LT
T
T
L
AIF
R
I
E
Q
D
NVA
Q
S
---
T
GT
P
I
PGSN
GE
T
AYKAVDGTV
SKGVE
F
ELN
---
GA
I
T
D
NWQL
TF
GA
T
R
Y
I
AE
DN
-------
E
G
N
A
VN
PNLP
-----
RTTVKMF
T
SY
R
L
P
VMP
E
---
LT
V
G
-----
GGV
N
W
KN
--
R
VY
TDT
VT
PY
G
-
TFR
A
EQ
GSYALVDLFTRY
Q
VTK
----
NF
SLQGNVNNLFDKTY
D
TN
VE
GSIVY
-
--
-
GAPR
N
F
SI
TGTYQF
fig|573235.3.peg.1468
Escherichia coli O26:H11 str. 11368
M
L
ST
Q
F
NRDNQ
Y
QA
ST
KPS
L
LAGCI
A
LAL
L
P
S
A
A
F
A
A
P
ATE
ETVIV
EG
SA
T
---
AP
D
D
GEN
DY
S
V
T
ST
------
SAGTKMQM
T
QR
DIPQSVT
I
VS
Q
Q
R
ME
D
QQ
LQ
TL
G
EV
M
E
NT
L
G
I
---
-
-
S
K
S
Q
A
D
S
D
R
A
LYY
SRGF
------
QI
DNYM
--
V
DGI
P
T
YFESR
WNLGDA
LS
DM
-
AL
F
ERVEVVRG
A
T
G
L
M
T
G
TG
NP
SA
AINMV
R
K
H
AT
SRE
------------
FKGDVSAEYGS
W
NK
ER
Y
VA
D
L
Q
SP
L
TE
DG
KIR
ARIVG
GY
QN
N
D
S
W
LDRYN
SE
K
TF
------
FSG
IV
D
A
DL
G
DL
T
T
LSAG
YEY
Q
H
IDVNS
P
T
WGG
----
LP
RW
N
T
D
-----
GS
S
N
SYDR
AR
ST
AP
D
WAY
ND
K
EI
N
--------
K
V
FM
TLK
Q
R
FADTWQAT
L
N
AT
HSE
V
EFD
SKMMY
V
D
AY
VNKADGML
I
GPYSNYGPGF
DY
V
G
GTG
WN
S
G
---------------------------
-
-
K
R
K
VDA
-------
--
-
--
-
-
---
-
L
D
LF
A
DG
SY
EL
FGR
QH
N
LMFGG
----------
SYSK
QN
N
RYFSSWANIFPD
EI
GSF
Y
N
FN
GN
F
P
QT
D
-
-
--
W
SP
-------------
----
---
------------QS
L
A
QDD
T
TH
I
KS
L
YAA
T
RVT
L
A
D
PLHLI
LG
A
R
-------
Y
----
--
-TNW
R
--------------
VDTLTY
-----
SM
EK
N
HT
----
TP
YA
GLVF
D
I
N
DNWS
T
YASYT
S
I
FQP
---------
Q
N
-
DR
D
SS
G
KY
-
L
A
P
I
TGNNYE
-------
LGLK
SDWM
N
SR
LT
T
T
L
AIF
R
I
E
Q
D
NVA
Q
S
---
T
GT
P
I
PGSN
GE
T
AYKAVDGTV
SKGVE
F
ELN
---
GA
I
T
D
NWQL
TF
GA
T
R
Y
I
AE
DN
-------
E
G
N
A
VN
PNLP
-----
RTTVKMF
T
SY
R
L
P
VMP
E
---
LT
V
G
-----
GGV
N
W
QN
--
R
VY
TDT
VT
PY
G
-
TFR
A
EQ
GSYALVDLFTRY
Q
VTK
----
NF
SLQGNVNNLFDKTY
D
TN
VE
GSIVY
-
--
-
GAPR
N
F
SI
TGTYQF
fig|585397.7.peg.1256
Escherichia coli ED1a
M
L
ST
Q
F
NRDNQ
H
QA
II
KPS
L
LAGCI
A
LAL
L
P
S
A
A
F
A
A
P
VTE
ETVIV
EG
SA
T
---
AP
D
D
GEN
DY
N
V
T
ST
------
SAGTKMQM
T
QR
DIPQSVT
I
VS
Q
Q
R
ME
D
QQ
LQ
TL
G
EV
M
E
NT
L
G
I
---
-
-
S
K
S
Q
A
D
S
D
R
A
LYY
SRGF
------
QI
DNYM
--
V
DGI
P
T
YFESR
WNLGDA
LS
DM
-
AL
F
ERVEVVRG
A
T
G
L
M
T
G
TG
NP
SA
AINMV
R
K
H
AT
SRE
------------
FKGDVSAEYGS
W
NK
ER
Y
VA
D
L
Q
SP
L
TE
DG
KIR
ARIVG
GY
QN
N
D
S
W
LDRYN
SE
K
A
F
------
FSG
IV
D
A
DL
G
DL
T
M
LSAG
YEY
Q
RIDVNS
P
T
WGG
----
LP
RW
N
T
D
-----
GS
S
N
SYDR
AR
ST
AP
D
WAY
ND
K
EI
N
--------
K
V
FM
TLK
Q
R
FADTWQAT
L
N
AT
HSE
V
EFD
SKMMY
V
D
AY
VNKADGMLVGPYSNYGPGF
DY
V
G
GTG
WN
S
G
---------------------------
-
-
K
R
K
VDA
-------
--
-
--
-
-
---
-
L
D
LF
A
DG
SY
EL
FGR
QH
N
LMFGG
----------
SYSK
QN
N
RYFSSWANIFPD
EI
GSF
Y
N
FN
GN
F
P
QT
D
-
-
--
W
SP
-------------
----
---
------------QS
L
A
QDD
T
TH
M
KS
L
YAA
T
RVT
L
A
D
PLHLI
LG
A
R
-------
Y
----
--
-TNW
R
--------------
VDTLTY
-----
SM
EK
N
HT
----
TP
YA
GLVF
D
I
N
DNWS
T
YASYT
S
I
FQP
---------
Q
N
-
DR
D
SS
G
KY
-
L
T
P
I
TGNNYE
-------
LGLK
SDWM
N
SR
LT
T
T
L
AIF
R
I
E
Q
D
NVA
Q
S
---
T
GT
P
I
PGSN
GE
T
AYKAVDGTV
SKGVE
F
ELN
---
GA
I
T
D
NWQL
TF
GA
T
R
Y
I
AE
DN
-------
E
G
N
A
VN
PNLP
-----
RTTVKMF
T
SY
R
L
P
VMP
E
---
LT
V
G
-----
GGV
N
W
QN
--
R
VY
TDT
VT
PY
G
-
TFR
A
EQ
GSYALVDLFTRY
Q
VTK
----
NF
SLQGNVNNLFDKTY
D
TN
VE
GSIVY
-
--
-
GAPR
N
F
SI
TGTYQF
fig|585397.9.peg.1252
Escherichia coli ED1a
M
L
ST
Q
F
NRDNQ
H
QA
II
KPS
L
LAGCI
A
LAL
L
P
S
A
A
F
A
A
P
VTE
ETVIV
EG
SA
T
---
AP
D
D
GEN
DY
N
V
T
ST
------
SAGTKMQM
T
QR
DIPQSVT
I
VS
Q
Q
R
ME
D
QQ
LQ
TL
G
EV
M
E
NT
L
G
I
---
-
-
S
K
S
Q
A
D
S
D
R
A
LYY
SRGF
------
QI
DNYM
--
V
DGI
P
T
YFESR
WNLGDA
LS
DM
-
AL
F
ERVEVVRG
A
T
G
L
M
T
G
TG
NP
SA
AINMV
R
K
H
AT
SRE
------------
FKGDVSAEYGS
W
NK
ER
Y
VA
D
L
Q
SP
L
TE
DG
KIR
ARIVG
GY
QN
N
D
S
W
LDRYN
SE
K
A
F
------
FSG
IV
D
A
DL
G
DL
T
M
LSAG
YEY
Q
RIDVNS
P
T
WGG
----
LP
RW
N
T
D
-----
GS
S
N
SYDR
AR
ST
AP
D
WAY
ND
K
EI
N
--------
K
V
FM
TLK
Q
R
FADTWQAT
L
N
AT
HSE
V
EFD
SKMMY
V
D
AY
VNKADGMLVGPYSNYGPGF
DY
V
G
GTG
WN
S
G
---------------------------
-
-
K
R
K
VDA
-------
--
-
--
-
-
---
-
L
D
LF
A
DG
SY
EL
FGR
QH
N
LMFGG
----------
SYSK
QN
N
RYFSSWANIFPD
EI
GSF
Y
N
FN
GN
F
P
QT
D
-
-
--
W
SP
-------------
----
---
------------QS
L
A
QDD
T
TH
M
KS
L
YAA
T
RVT
L
A
D
PLHLI
LG
A
R
-------
Y
----
--
-TNW
R
--------------
VDTLTY
-----
SM
EK
N
HT
----
TP
YA
GLVF
D
I
N
DNWS
T
YASYT
S
I
FQP
---------
Q
N
-
DR
D
SS
G
KY
-
L
T
P
I
TGNNYE
-------
LGLK
SDWM
N
SR
LT
T
T
L
AIF
R
I
E
Q
D
NVA
Q
S
---
T
GT
P
I
PGSN
GE
T
AYKAVDGTV
SKGVE
F
ELN
---
GA
I
T
D
NWQL
TF
GA
T
R
Y
I
AE
DN
-------
E
G
N
A
VN
PNLP
-----
RTTVKMF
T
SY
R
L
P
VMP
E
---
LT
V
G
-----
GGV
N
W
QN
--
R
VY
TDT
VT
PY
G
-
TFR
A
EQ
GSYALVDLFTRY
Q
VTK
----
NF
SLQGNVNNLFDKTY
D
TN
VE
GSIVY
-
--
-
GAPR
N
F
SI
TGTYQF
fig|685038.3.peg.1070
Escherichia coli O83:H1 str. NRG 857C
M
L
ST
Q
F
NRDNQ
H
QA
II
KPS
L
LAGCI
A
LAL
L
P
S
A
A
F
A
A
P
VTE
ETVIV
EG
SA
T
---
AP
D
D
GEN
DY
N
V
T
ST
------
SAGTKMQM
T
QR
DIPQSVT
I
VS
Q
Q
R
ME
D
QQ
LQ
TL
G
EV
M
E
NT
L
G
I
---
-
-
S
K
S
Q
A
D
S
D
R
A
LYY
SRGF
------
QI
DNYM
--
V
DGI
P
T
YFESR
WNLGDA
LS
DM
-
AL
F
ERVEVVRG
A
T
G
L
M
T
G
TG
NP
SA
AINMV
R
K
H
AT
SRE
------------
FKGDVSAEYGS
W
NK
ER
Y
VA
D
L
Q
SP
L
TE
DG
KIR
ARIVG
GY
QN
N
D
S
W
LDRYN
SE
K
TF
------
FSG
IV
D
A
DL
G
DL
T
M
LSAG
YEY
Q
RIDVNS
P
T
WGG
----
LP
RW
N
T
D
-----
GS
S
N
SYDR
AR
ST
AP
D
WAY
ND
K
EI
N
--------
K
V
FM
TLK
Q
R
FADTWQAT
L
N
AT
HSE
V
EFD
SKMMY
V
D
AY
VNKADGMLVGPYSNYGPGF
DY
V
G
GTG
WN
S
G
---------------------------
-
-
K
R
K
VDA
-------
--
-
--
-
-
---
-
L
D
LF
A
DG
SY
EL
FGR
QH
N
LMFGG
----------
SYSK
QN
N
RYFSSWANIFPD
EI
GSF
Y
N
FN
GN
F
P
QT
D
-
-
--
W
SP
-------------
----
---
------------QS
L
A
Q
N
D
T
TH
M
KS
L
YAA
T
RVT
L
A
D
PLHLI
LG
A
R
-------
Y
----
--
-TNW
R
--------------
VDTLTY
-----
SM
EK
N
HT
----
TP
YA
GLVF
D
I
N
DNWS
T
YASYT
S
I
FQP
---------
Q
N
-
DR
D
SS
G
KY
-
L
T
P
I
TGNNYE
-------
LGLK
SDWM
N
SR
LT
T
T
L
AIF
R
I
E
Q
D
NVA
Q
S
---
T
GT
P
I
PGSN
GE
T
AYKAVDGTV
SKGVE
F
ELN
---
GA
I
T
D
NWQL
TF
GA
T
R
Y
I
AE
DN
-------
E
G
N
A
VN
PNLP
-----
RTTVKMF
T
SY
R
L
P
VMP
E
---
LT
V
G
-----
GGV
N
W
QN
--
R
VY
TDT
VT
PY
G
-
TFR
A
EQ
GSYALVDLFTRY
Q
VTK
----
NF
SLQGNVNNLFDKTY
D
TN
VE
GSIVY
-
--
-
GAPR
N
F
SI
TGTYQF
fig|362663.8.peg.1114
Escherichia coli 536
M
L
ST
Q
F
NRDNQ
H
QA
II
KPS
L
LAGCI
A
LAL
L
P
S
A
A
F
A
A
P
ATE
ETVIV
EG
SA
T
---
AP
D
D
GEN
DY
N
V
T
ST
------
SAGTKMQM
T
QR
DIPQSVT
I
VS
Q
Q
R
ME
D
QQ
LQ
TL
G
EV
M
E
NT
L
G
I
---
-
-
S
K
S
Q
A
D
S
D
R
A
LYY
SRGF
------
QI
DNYM
--
V
DGI
P
T
YFESR
WNLGDA
LS
DM
-
AL
F
ERVEVVRG
A
T
G
L
M
T
G
TG
NP
SA
AINMV
R
K
H
AT
SRE
------------
FKGDVSAEYGS
W
NK
ER
Y
VA
D
L
Q
SP
L
TE
DG
KIR
ARIVG
GY
QN
N
D
S
W
LDRYN
SE
K
TF
------
FSG
IV
D
A
DL
G
DL
T
M
LSAG
YEY
Q
RIDVNS
P
T
WGG
----
LP
RW
N
T
D
-----
GS
S
N
SYDR
AR
ST
AP
D
WAY
ND
K
EI
N
--------
K
V
FM
TLK
Q
R
FADTWQAT
L
N
AT
HSE
V
EFD
SKMMY
V
D
AY
VNKADGMLVGPYSNYGPGF
DY
V
G
GTG
WN
S
G
---------------------------
-
-
K
R
K
VDA
-------
--
-
--
-
-
---
-
L
D
LF
A
DG
SY
EL
FGR
QH
N
LMFGG
----------
SYSK
QN
N
RYFSSWANIFPD
EI
GSF
Y
N
FN
GN
F
P
QT
D
-
-
--
W
SP
-------------
----
---
------------QS
L
A
Q
N
D
T
TH
M
KS
L
YAA
T
RVT
L
A
D
PLHLI
LG
A
R
-------
Y
----
--
-TNW
R
--------------
VDTLTY
-----
SM
EK
N
HT
----
TP
YA
GLVF
D
I
N
DNWS
T
YASYT
S
I
FQP
---------
Q
N
-
DR
D
SS
G
KY
-
L
T
P
I
TGNNYE
-------
LGLK
SDWM
N
SR
LT
T
T
L
AIF
R
I
E
Q
D
NVA
Q
S
---
T
GT
P
I
PGSN
GE
T
AYKAVDGTV
SKGVE
F
ELN
---
GA
I
T
D
NWQL
TF
GA
T
R
Y
I
AE
DN
-------
E
G
N
A
VN
PNLP
-----
RTT
F
KMF
T
SY
R
L
P
VMP
E
---
LT
V
G
-----
GGV
N
W
QN
--
R
VY
TDT
VT
PY
G
-
TFR
A
EQ
GSYALVDLFTRY
Q
VTK
----
NF
SLQGNVNNLFDKTY
D
TN
VE
GSIVY
-
--
-
GAPR
N
F
SI
TGTYQF
fig|362663.9.peg.1114
Escherichia coli 536
M
L
ST
Q
F
NRDNQ
H
QA
II
KPS
L
LAGCI
A
LAL
L
P
S
A
A
F
A
A
P
ATE
ETVIV
EG
SA
T
---
AP
D
D
GEN
DY
N
V
T
ST
------
SAGTKMQM
T
QR
DIPQSVT
I
VS
Q
Q
R
ME
D
QQ
LQ
TL
G
EV
M
E
NT
L
G
I
---
-
-
S
K
S
Q
A
D
S
D
R
A
LYY
SRGF
------
QI
DNYM
--
V
DGI
P
T
YFESR
WNLGDA
LS
DM
-
AL
F
ERVEVVRG
A
T
G
L
M
T
G
TG
NP
SA
AINMV
R
K
H
AT
SRE
------------
FKGDVSAEYGS
W
NK
ER
Y
VA
D
L
Q
SP
L
TE
DG
KIR
ARIVG
GY
QN
N
D
S
W
LDRYN
SE
K
TF
------
FSG
IV
D
A
DL
G
DL
T
M
LSAG
YEY
Q
RIDVNS
P
T
WGG
----
LP
RW
N
T
D
-----
GS
S
N
SYDR
AR
ST
AP
D
WAY
ND
K
EI
N
--------
K
V
FM
TLK
Q
R
FADTWQAT
L
N
AT
HSE
V
EFD
SKMMY
V
D
AY
VNKADGMLVGPYSNYGPGF
DY
V
G
GTG
WN
S
G
---------------------------
-
-
K
R
K
VDA
-------
--
-
--
-
-
---
-
L
D
LF
A
DG
SY
EL
FGR
QH
N
LMFGG
----------
SYSK
QN
N
RYFSSWANIFPD
EI
GSF
Y
N
FN
GN
F
P
QT
D
-
-
--
W
SP
-------------
----
---
------------QS
L
A
Q
N
D
T
TH
M
KS
L
YAA
T
RVT
L
A
D
PLHLI
LG
A
R
-------
Y
----
--
-TNW
R
--------------
VDTLTY
-----
SM
EK
N
HT
----
TP
YA
GLVF
D
I
N
DNWS
T
YASYT
S
I
FQP
---------
Q
N
-
DR
D
SS
G
KY
-
L
T
P
I
TGNNYE
-------
LGLK
SDWM
N
SR
LT
T
T
L
AIF
R
I
E
Q
D
NVA
Q
S
---
T
GT
P
I
PGSN
GE
T
AYKAVDGTV
SKGVE
F
ELN
---
GA
I
T
D
NWQL
TF
GA
T
R
Y
I
AE
DN
-------
E
G
N
A
VN
PNLP
-----
RTT
F
KMF
T
SY
R
L
P
VMP
E
---
LT
V
G
-----
GGV
N
W
QN
--
R
VY
TDT
VT
PY
G
-
TFR
A
EQ
GSYALVDLFTRY
Q
VTK
----
NF
SLQGNVNNLFDKTY
D
TN
VE
GSIVY
-
--
-
GAPR
N
F
SI
TGTYQF
fig|656417.3.peg.1341
Escherichia coli M605
M
L
ST
Q
F
NRDNQ
H
QA
II
KPS
L
LAGCI
A
LAL
L
P
S
A
A
F
A
A
P
ATE
ETVIV
EG
SA
T
---
AP
D
D
GEN
DY
N
V
T
ST
------
SAGTKMQM
T
QR
DIPQSVT
I
VS
Q
Q
R
ME
D
QQ
LQ
TL
G
EV
M
E
NT
L
G
I
---
-
-
S
K
S
Q
A
D
S
D
R
A
LYY
SRGF
------
QI
DNYM
--
V
DGI
P
T
YFESR
WNLGDA
LS
DM
-
AL
F
ERVEVVRG
A
T
G
L
M
T
G
TG
NP
SA
AINMV
R
K
H
AT
SRE
------------
FKGDVSAEYGS
W
NK
ER
Y
VA
D
L
Q
SP
L
TE
DG
KIR
ARIVG
GY
QN
N
D
S
W
LDRYN
SE
K
TF
------
FSG
IV
D
A
DL
G
DL
T
M
LSAG
YEY
Q
RIDVNS
P
T
WGG
----
LP
RW
N
T
D
-----
GS
S
N
SYDR
AR
ST
AP
D
WAY
ND
K
EI
N
--------
K
V
FM
TLK
Q
R
FADTWQAT
L
N
AT
HSE
V
EFD
SKMMY
V
D
AY
VNKADGMLVGPYSNYGPGF
DY
V
G
GTG
WN
S
G
---------------------------
-
-
K
R
K
VDA
-------
--
-
--
-
-
---
-
L
D
LF
A
DG
SY
EL
FGR
QH
N
LMFGG
----------
SYSK
QN
N
RYFSSWANIFPD
EI
GSF
Y
N
FN
GN
F
P
QT
D
-
-
--
R
SP
-------------
----
---
------------QS
L
A
QDD
T
TH
M
KS
L
YAA
T
RVT
L
A
D
PLHLI
LG
A
R
-------
Y
----
--
-TNW
R
--------------
VDTLTY
-----
SM
EK
N
HT
----
TP
YA
GLVF
D
I
N
DNWS
T
YASYT
S
I
FQP
---------
Q
N
-
DR
D
SS
G
KY
-
L
A
P
I
TGNNYE
-------
LGLK
SDWM
N
SR
LT
T
T
L
AIF
R
I
E
Q
D
NVA
Q
S
---
T
GT
P
I
PGSN
GE
T
AYKAVDGTV
SKGVE
F
ELN
---
GA
I
T
D
NWQL
TF
GA
T
R
Y
I
AE
DN
-------
E
G
N
A
VN
PNLP
-----
RTTVKMF
T
SY
R
L
P
VMP
E
---
LT
V
G
-----
GGV
N
W
QN
--
R
VY
TDT
VT
PY
G
-
TFR
A
EQ
GSYALVDLFTRY
Q
VTK
----
NF
SLQGNVNNLFDKTY
D
TN
VE
GSIVY
-
--
-
GAPR
N
L
SI
TGTYQF
fig|670888.3.peg.1729
Escherichia coli 1827-70
M
L
ST
Q
F
NRDNQ
Y
QA
IT
KPS
L
LAGCI
A
LAL
L
P
S
A
A
F
A
A
P
ATE
ETVIV
EG
SA
T
---
AP
D
D
GEN
DY
S
V
T
ST
------
SAGTKMQM
T
QR
DIPQSVT
I
VS
Q
Q
R
ME
D
QQ
LQ
TL
G
EV
M
E
NT
L
G
I
---
-
-
S
K
S
Q
A
D
S
D
R
A
LYY
SRGF
------
QI
DNYM
--
V
DGI
P
T
YFESR
WNLGDA
LS
DM
-
AL
F
ERVEVVRG
A
T
G
L
M
T
G
TG
NP
SA
AINMV
R
K
H
AT
SRE
------------
FKGDVSAEYGS
W
NK
ER
Y
VA
D
L
Q
SP
L
TE
DG
KIR
ARIVG
GY
QN
N
D
S
W
LDRYN
SE
K
TF
------
FSG
IV
D
A
DL
G
DL
T
T
LSAG
YEY
Q
R
N
DVNS
P
T
WGG
----
LP
RW
N
T
D
-----
GS
S
N
SYDR
AR
ST
AP
D
WAY
ND
K
EI
N
--------
K
V
FM
TLK
Q
R
FADTWQAT
L
N
AT
HSE
V
EFD
SKMMY
V
D
AY
VNKADGMLVGPYSNY
A
PGF
DY
V
G
GTG
WN
S
G
---------------------------
-
-
K
R
K
VDA
-------
--
-
--
-
-
---
-
L
D
LF
A
DG
SY
EL
FGR
QH
N
LMFGG
----------
SYSK
QN
N
RYFSSWANIFPD
EI
GSF
Y
N
FN
GN
F
P
QT
D
-
-
--
W
SP
-------------
----
---
------------QS
L
A
QDD
T
TH
M
KS
L
YAA
T
RVT
L
A
D
PLHLI
LG
A
R
-------
Y
----
--
-TNW
R
--------------
VDTLTY
-----
SM
EK
N
HT
----
TP
YA
GLVF
D
I
N
DNWS
T
YASYT
S
I
FQP
---------
Q
N
-
DR
D
SS
G
KY
-
L
A
P
I
TGNNYE
-------
LGLK
SDWM
N
SR
LT
T
T
L
AIF
R
I
E
Q
D
NVA
Q
S
---
T
GT
P
I
PGSN
GE
T
AYKAVDGTV
SKGVE
F
ELN
---
GA
I
T
D
NWQL
TF
GA
T
R
Y
I
AE
DN
-------
E
G
N
A
VN
PNLP
-----
RTTVKMF
T
SY
R
L
P
VMP
E
---
LT
V
G
-----
GGV
N
W
QN
--
R
VY
T
N
T
VT
PY
G
-
TFR
A
EQ
GSYALVDLFTRY
Q
VTK
----
NF
SLQGNVNNLFDKTY
D
TN
VE
GSIVY
-
--
-
G
T
PR
N
F
SI
T
S
TYQF
fig|701177.3.peg.1353
Escherichia coli O55:H7 str. CB9615
M
L
ST
Q
F
NRDNQ
Y
QA
IT
KPS
L
LAGCI
-
--
L
L
P
S
A
A
F
A
A
P
ATE
ETVIV
EG
SA
T
---
AP
D
D
GEN
DY
S
V
T
ST
------
SAGTKMQM
T
QR
DIPQSVT
I
VS
Q
Q
R
ME
D
QQ
LQ
TL
G
EV
M
E
NT
L
G
I
---
-
-
S
K
S
Q
A
D
S
D
R
A
LYY
SRGF
------
QI
DNYM
--
V
DGI
P
T
YFESR
WNLGDA
LS
DM
-
AL
F
ERVEVVRG
A
T
G
L
M
T
G
TG
NP
SA
AINMV
R
K
H
AT
SRE
------------
FKGDVSAEYGS
W
NK
ER
Y
VA
D
L
Q
SP
L
TE
DG
KIR
ARIVG
GY
QN
N
D
S
W
LDRYN
SE
K
TF
------
FSG
IV
D
A
DL
G
DL
T
T
LSAG
YEY
Q
RIDVNS
P
T
WGG
----
LP
RW
N
T
D
-----
GS
S
N
SYDR
AR
ST
AP
D
WAY
ND
K
EI
N
--------
K
V
FM
TLK
Q
R
FADTWQAT
L
N
AT
HSE
V
EFD
SKMMY
V
D
AY
VNKADGMLVGPYSNYGPGF
DY
V
G
GTG
WN
S
G
---------------------------
-
-
K
R
K
VDA
-------
--
-
--
-
-
---
-
L
D
LF
A
DG
SY
EL
FGR
QH
N
LMFGG
----------
SYSK
QN
N
RYFSSWANIFPD
EI
GSF
Y
N
FN
GN
F
P
QT
D
-
-
--
W
SP
-------------
----
---
------------QS
L
A
QDD
T
TH
M
KS
L
YAA
T
RVT
L
A
D
PLHLI
LG
A
R
-------
Y
----
--
-TNW
R
--------------
VDTLTY
-----
SM
EK
N
HT
----
TP
YA
GLVF
D
I
N
DNWS
T
YASYT
S
I
FQP
---------
Q
N
-
DR
D
SS
G
KY
-
L
A
P
I
TGNNYE
-------
LGLK
SDWM
N
SR
LT
T
T
L
AIF
R
I
E
Q
D
NVA
Q
S
---
T
GT
P
I
PGSN
GE
T
AYKAVDGTV
SKGVE
F
ELN
---
GA
I
T
D
NWQL
TF
GA
T
R
Y
I
AE
DN
-------
E
G
N
A
VN
PNLP
-----
RTTVKMF
T
SY
R
L
P
VMP
E
---
LT
V
G
-----
GGV
N
W
QN
--
R
VY
TDT
VT
PY
G
-
TFR
A
EQ
GSYALVDLFTRY
Q
VTK
----
NF
SLQGNVNNLFDKTY
D
TN
VE
GSIVY
-
--
-
GAPR
N
F
SI
TGTYQF
fig|431946.3.peg.1050
Escherichia coli SE15
M
L
ST
Q
F
NRDNQ
H
QA
II
KPS
L
LAGCI
A
LAL
L
P
S
A
A
F
A
A
P
ATE
ETVIV
EG
SA
T
---
AP
D
D
GEN
DY
N
V
T
ST
------
SAGTKMQM
T
QR
DIPQSVT
I
VS
Q
Q
R
ME
D
QQ
LQ
TL
G
EV
M
E
NT
L
G
I
---
-
-
S
K
S
Q
A
D
S
D
R
A
LYY
SRGF
------
QI
DNYM
--
V
DGI
P
T
YFESR
WNLGDA
LS
DM
-
AL
F
ERVEVVRG
A
T
G
L
M
T
G
TG
NP
SA
AINMV
R
K
H
AT
SRE
------------
FKGDVSAEYGS
W
NK
ER
Y
VA
D
L
Q
SP
L
TE
DG
KIR
ARIVG
GY
QN
N
D
S
W
LDRYN
SE
K
TF
------
FSG
IV
D
A
DL
G
DL
T
M
LSAG
YEY
Q
RIDVNS
P
T
WGG
----
LP
RW
N
T
D
-----
GS
S
N
SYDR
AR
ST
AP
D
WAY
ND
K
EI
N
--------
K
V
FM
TLK
Q
R
FADTWQAT
L
N
AT
HSE
V
EFD
SKMMY
V
D
AY
VNKADGMLVGPYSNYGPGF
DY
V
G
GTG
WN
S
G
---------------------------
-
-
K
R
K
VDA
-------
--
-
--
-
-
---
-
L
D
LF
A
DG
SY
EL
FGR
QH
N
LMFGG
----------
SYSK
QN
N
RYFSSWANIFPD
EI
GSF
Y
N
FN
GN
F
P
QT
D
-
-
--
R
SP
-------------
----
---
------------QS
L
A
QDD
T
TH
M
KS
L
YAA
T
RVT
L
A
D
PLHLI
LG
A
R
-------
Y
----
--
-TKW
R
--------------
VDTLTY
-----
SM
EK
N
HT
----
TP
YA
GLVF
D
I
N
DNWS
T
YASYT
S
I
FQP
---------
Q
N
-
DR
D
SS
G
KY
-
L
A
P
I
TGNNYE
-------
LGLK
SDWM
N
SR
LT
T
T
L
AIF
R
I
E
Q
D
NVA
Q
S
---
T
GT
P
I
PGSN
GE
T
AYKAVDGTV
SKGVE
F
ELN
---
GA
I
T
D
NWQL
TF
GA
T
R
Y
I
AE
DN
-------
E
G
N
A
VN
PNLP
-----
RTTVKMF
T
SY
R
L
P
VMP
E
---
LT
V
G
-----
GGV
N
W
QN
--
R
VY
TDT
VT
PY
G
-
TFR
A
EQ
GSYALVDLFTRY
Q
VTK
----
NF
SLQGNVNNLFDKTY
D
TN
VE
GSIVY
-
--
-
GAPR
N
L
SI
TG
M
YQF
fig|585057.4.peg.2140
Escherichia coli IAI39
M
L
ST
Q
F
NRDNQ
H
QA
II
KPS
L
LAGCI
A
LAL
L
P
S
A
A
F
A
A
P
ATE
ETVIV
EG
SA
T
---
AP
D
N
GEN
DY
N
V
T
ST
------
SAGTKMQM
T
QR
DIPQSVT
I
VS
Q
Q
R
ME
D
QQ
LQ
TL
G
EV
M
E
NT
L
G
I
---
-
-
S
K
S
Q
A
D
S
D
R
A
LYY
SRGF
------
QI
DNYM
--
V
DGI
P
T
YFESR
WNLGDA
LS
DM
-
AL
F
ERVEVVRG
A
T
G
L
M
T
G
TG
NP
SA
AINM
I
R
K
H
AT
SRE
------------
FKGDVSAEYGS
W
NK
ER
Y
VA
D
L
Q
SP
L
TE
DG
KIR
ARIVG
GY
QN
N
D
S
W
LDRYN
SE
K
TF
------
FSG
IV
D
A
DL
G
DL
T
T
LSAG
YEY
Q
RIDVNS
P
T
R
GG
----
LP
RW
N
T
D
-----
GS
S
N
SYDR
AR
ST
AP
D
WAY
ND
K
EI
N
--------
K
V
FM
TLK
Q
R
FADTWQAT
L
N
AT
HSE
V
EFD
SKMMY
V
D
AY
VNKADGMLVGPYSNYGPGF
DY
V
G
GTG
WN
S
G
---------------------------
-
-
K
R
K
VDA
-------
--
-
--
-
-
---
-
L
D
LF
A
DG
SY
EL
FGR
QH
N
LMFGG
----------
SYSK
QN
N
RY
I
SSWANIFPD
EI
GSF
Y
N
FN
GN
F
P
QT
D
-
-
--
W
SP
-------------
----
---
------------QS
L
A
QDD
T
TH
M
KS
L
YAA
T
RVT
L
A
D
PLHLI
LG
A
R
-------
Y
----
--
-TNW
R
--------------
VDTLTY
-----
SM
EK
N
HT
----
TP
YA
GLVF
D
I
N
DNWS
T
YASYT
S
I
FQP
---------
Q
N
-
DR
D
SS
G
KY
-
L
A
P
I
TGNNYE
-------
LGLK
SDWM
N
SR
LT
T
T
L
AIF
R
I
E
Q
D
NVA
Q
S
---
T
GT
P
I
PGSN
GE
T
AYKAVDGTV
SKGVE
F
ELN
---
GA
I
T
D
NW
X
L
TF
GA
T
R
Y
I
AE
DN
-------
E
G
N
A
VN
PNLP
-----
RTTVKMF
T
SY
R
L
P
VMP
E
---
LT
V
G
-----
GGV
N
W
QN
--
R
VY
TDT
VT
PY
G
-
TFR
A
EQ
GSYALVDLFTRY
Q
VTK
----
NF
SLQGNVNNLFDKTY
D
TN
VE
GSIVY
-
--
-
GAPR
N
F
SI
TGTYQF
fig|155864.1.peg.1544
Escherichia coli O157:H7 EDL933
M
L
ST
Q
F
NRDNQ
Y
QA
IT
KPS
L
LAGCI
A
LAL
L
P
S
A
A
X
A
A
P
ATE
ETVIV
EG
SA
T
---
AP
D
D
GEN
DY
S
V
T
ST
------
SAGTKMQM
T
QR
DIPQSVT
I
VS
Q
Q
R
ME
D
QQ
LQ
TL
G
EV
M
E
NT
L
G
I
---
-
-
S
K
S
Q
A
D
S
D
R
A
LYY
SRGF
------
QI
DNYM
--
V
DGI
P
T
YFESR
WNLGDA
LS
DM
-
AL
F
ERVEVVRG
A
T
G
L
M
T
G
TG
NP
SA
AINMV
R
K
H
AT
SRE
------------
FKGDVSAEYGS
W
NK
ER
Y
VA
D
L
Q
SP
L
TE
DG
KIR
ARIVG
GY
QN
N
D
S
W
LDRYN
SE
K
TF
------
FSG
IV
D
A
DL
G
DL
T
T
LSAG
YEY
Q
RIDVNS
P
T
WGG
----
LP
RW
N
T
D
-----
GS
S
N
SYDR
AR
ST
AP
D
WAY
ND
K
EI
N
--------
K
V
FM
TLK
Q
R
FADTWQAT
L
N
AT
HSE
V
EFD
SKMMY
V
D
AY
VNKADGMLVGPYSNYGPGF
DY
V
G
GTG
WN
S
G
---------------------------
-
-
K
R
K
VDA
-------
--
-
--
-
-
---
-
L
D
LF
A
DG
SY
EL
FGR
QH
N
LMFGG
----------
SYSK
QN
N
RYFSSWANIFPD
EI
GSF
Y
N
FN
GN
F
P
QT
D
-
-
--
W
SP
-------------
----
---
------------QS
L
A
QDD
T
TH
M
KS
L
YAA
T
RVT
L
A
D
PLHLI
LG
A
R
-------
Y
----
--
-TNW
R
--------------
VDTLTY
-----
SM
EK
N
HT
----
TP
YA
GLVF
D
I
N
DNWS
T
YASYT
S
I
FQP
---------
Q
N
-
DR
D
SS
G
KY
-
L
A
P
I
TGNNYE
-------
LGLK
SDWM
N
SR
LT
T
T
L
AIF
R
I
E
Q
D
NVA
Q
S
---
T
GT
P
I
PGSN
GE
T
AYKAVDGTV
SKGVE
F
ELN
---
GA
I
T
D
NWQL
TF
GA
T
R
Y
I
AE
DN
-------
E
G
N
A
VN
PNLP
-----
RTTVKMF
T
SY
R
L
P
VMP
E
---
LT
V
G
-----
GGV
N
W
QN
--
R
VY
TDT
VT
PY
G
-
TFR
A
EQ
GSYALVDLFTRY
Q
VTK
----
NF
SLQGNVNNLFDKTY
D
TN
VE
GSIVY
-
--
-
GAPR
N
F
SI
TGTYQF
fig|155864.8.peg.1325
Escherichia coli O157:H7 EDL933
M
L
ST
Q
F
NRDNQ
Y
QA
IT
KPS
L
LAGCI
A
LAL
L
P
S
A
A
X
A
A
P
ATE
ETVIV
EG
SA
T
---
AP
D
D
GEN
DY
S
V
T
ST
------
SAGTKMQM
T
QR
DIPQSVT
I
VS
Q
Q
R
ME
D
QQ
LQ
TL
G
EV
M
E
NT
L
G
I
---
-
-
S
K
S
Q
A
D
S
D
R
A
LYY
SRGF
------
QI
DNYM
--
V
DGI
P
T
YFESR
WNLGDA
LS
DM
-
AL
F
ERVEVVRG
A
T
G
L
M
T
G
TG
NP
SA
AINMV
R
K
H
AT
SRE
------------
FKGDVSAEYGS
W
NK
ER
Y
VA
D
L
Q
SP
L
TE
DG
KIR
ARIVG
GY
QN
N
D
S
W
LDRYN
SE
K
TF
------
FSG
IV
D
A
DL
G
DL
T
T
LSAG
YEY
Q
RIDVNS
P
T
WGG
----
LP
RW
N
T
D
-----
GS
S
N
SYDR
AR
ST
AP
D
WAY
ND
K
EI
N
--------
K
V
FM
TLK
Q
R
FADTWQAT
L
N
AT
HSE
V
EFD
SKMMY
V
D
AY
VNKADGMLVGPYSNYGPGF
DY
V
G
GTG
WN
S
G
---------------------------
-
-
K
R
K
VDA
-------
--
-
--
-
-
---
-
L
D
LF
A
DG
SY
EL
FGR
QH
N
LMFGG
----------
SYSK
QN
N
RYFSSWANIFPD
EI
GSF
Y
N
FN
GN
F
P
QT
D
-
-
--
W
SP
-------------
----
---
------------QS
L
A
QDD
T
TH
M
KS
L
YAA
T
RVT
L
A
D
PLHLI
LG
A
R
-------
Y
----
--
-TNW
R
--------------
VDTLTY
-----
SM
EK
N
HT
----
TP
YA
GLVF
D
I
N
DNWS
T
YASYT
S
I
FQP
---------
Q
N
-
DR
D
SS
G
KY
-
L
A
P
I
TGNNYE
-------
LGLK
SDWM
N
SR
LT
T
T
L
AIF
R
I
E
Q
D
NVA
Q
S
---
T
GT
P
I
PGSN
GE
T
AYKAVDGTV
SKGVE
F
ELN
---
GA
I
T
D
NWQL
TF
GA
T
R
Y
I
AE
DN
-------
E
G
N
A
VN
PNLP
-----
RTTVKMF
T
SY
R
L
P
VMP
E
---
LT
V
G
-----
GGV
N
W
QN
--
R
VY
TDT
VT
PY
G
-
TFR
A
EQ
GSYALVDLFTRY
Q
VTK
----
NF
SLQGNVNNLFDKTY
D
TN
VE
GSIVY
-
--
-
GAPR
N
F
SI
TGTYQF
fig|656379.3.peg.1945
Escherichia coli FVEC1302
M
L
ST
Q
F
NRDNQ
H
Q
T
TS
KPS
L
LA
A
CI
A
LAL
L
P
S
A
A
F
A
A
P
ATE
ETVIV
EG
SA
T
---
AP
D
D
GEN
DY
S
V
T
ST
------
SAGTKMQM
T
QR
DIPQSVT
I
VS
Q
Q
R
ME
D
QQ
LQ
TL
G
EV
M
E
NT
L
G
I
---
-
-
S
K
S
Q
A
D
S
D
R
A
LYY
SRGF
------
QI
DNYM
--
V
DGI
P
T
YFESR
WNLGDA
LS
DM
-
AL
F
ERVEVVRG
A
T
G
L
M
T
G
TG
NP
SA
AINMV
R
K
H
AT
SRE
------------
FKGDVSAEYGS
W
NK
ER
Y
VA
D
L
Q
SP
L
TE
DG
KIR
ARIVG
GY
QN
N
D
S
W
LDRYN
SE
K
TF
------
FSG
IV
D
A
DL
G
DL
T
T
LSAG
YEY
Q
RIDVNS
P
T
WGG
----
LP
RW
N
T
D
-----
GS
S
N
SYDR
AR
ST
AP
D
WAY
ND
K
EI
N
--------
K
V
FM
TLK
Q
R
FADTWQAT
L
N
AT
HSE
V
EFD
SKMMY
V
D
AY
VNKADGMLVGPYSNYGPGF
DY
V
G
GTG
WN
S
G
---------------------------
-
-
K
R
K
VDA
-------
--
-
--
-
-
---
-
L
D
LF
A
DG
SY
EL
FGR
QH
N
LMFGG
----------
SYSK
QN
N
RYFSSWANIFPD
EI
GSF
Y
N
FN
GN
F
P
QT
D
-
-
--
W
SP
-------------
----
---
------------QS
L
A
QDD
T
TH
M
KS
L
YAA
T
RVT
L
A
D
PLHLI
LG
A
R
-------
Y
----
--
-TNW
R
--------------
VDTLTY
-----
SM
EK
N
HT
----
TP
YA
GLVF
D
I
N
DNWS
T
YASYT
S
I
FQP
---------
Q
N
-
DR
D
SS
G
KY
-
L
A
P
I
TGNNYE
-------
LGLK
SDWM
N
SR
LT
T
T
L
AIF
R
I
E
Q
D
NVA
Q
S
---
T
GT
P
I
PGSN
GE
T
AYKAVDGTV
SKGVE
F
ELN
---
GA
I
T
D
NWQL
TF
GA
T
R
Y
I
AE
DN
-------
E
G
N
A
VN
PNLP
-----
RTTVKMF
T
SY
R
L
P
VMP
E
---
LT
V
G
-----
GGV
N
W
QN
--
R
VY
TDT
VT
PY
G
-
TFR
A
EQ
GSYALVDLFTRY
Q
VTK
----
NF
SLQGNVNNLFDKTY
D
TN
VE
GSIVY
-
--
-
GAPR
N
F
SI
TGTYQF
fig|656380.3.peg.1777
Escherichia coli FVEC1412
M
L
ST
Q
F
NRDNQ
H
Q
T
TS
KPS
L
LA
A
CI
A
LAL
L
P
S
A
A
F
A
A
P
ATE
ETVIV
EG
SA
T
---
AP
D
D
GEN
DY
S
V
T
ST
------
SAGTKMQM
T
QR
DIPQSVT
I
VS
Q
Q
R
ME
D
QQ
LQ
TL
G
EV
M
E
NT
L
G
I
---
-
-
S
K
S
Q
A
D
S
D
R
A
LYY
SRGF
------
QI
DNYM
--
V
DGI
P
T
YFESR
WNLGDA
LS
DM
-
AL
F
ERVEVVRG
A
T
G
L
M
T
G
TG
NP
SA
AINMV
R
K
H
AT
SRE
------------
FKGDVSAEYGS
W
NK
ER
Y
VA
D
L
Q
SP
L
TE
DG
KIR
ARIVG
GY
QN
N
D
S
W
LDRYN
SE
K
TF
------
FSG
IV
D
A
DL
G
DL
T
T
LSAG
YEY
Q
RIDVNS
P
T
WGG
----
LP
RW
N
T
D
-----
GS
S
N
SYDR
AR
ST
AP
D
WAY
ND
K
EI
N
--------
K
V
FM
TLK
Q
R
FADTWQAT
L
N
AT
HSE
V
EFD
SKMMY
V
D
AY
VNKADGMLVGPYSNYGPGF
DY
V
G
GTG
WN
S
G
---------------------------
-
-
K
R
K
VDA
-------
--
-
--
-
-
---
-
L
D
LF
A
DG
SY
EL
FGR
QH
N
LMFGG
----------
SYSK
QN
N
RYFSSWANIFPD
EI
GSF
Y
N
FN
GN
F
P
QT
D
-
-
--
W
SP
-------------
----
---
------------QS
L
A
QDD
T
TH
M
KS
L
YAA
T
RVT
L
A
D
PLHLI
LG
A
R
-------
Y
----
--
-TNW
R
--------------
VDTLTY
-----
SM
EK
N
HT
----
TP
YA
GLVF
D
I
N
DNWS
T
YASYT
S
I
FQP
---------
Q
N
-
DR
D
SS
G
KY
-
L
A
P
I
TGNNYE
-------
LGLK
SDWM
N
SR
LT
T
T
L
AIF
R
I
E
Q
D
NVA
Q
S
---
T
GT
P
I
PGSN
GE
T
AYKAVDGTV
SKGVE
F
ELN
---
GA
I
T
D
NWQL
TF
GA
T
R
Y
I
AE
DN
-------
E
G
N
A
VN
PNLP
-----
RTTVKMF
T
SY
R
L
P
VMP
E
---
LT
V
G
-----
GGV
N
W
QN
--
R
VY
TDT
VT
PY
G
-
TFR
A
EQ
GSYALVDLFTRY
Q
VTK
----
NF
SLQGNVNNLFDKTY
D
TN
VE
GSIVY
-
--
-
GAPR
N
F
SI
TGTYQF
fig|749549.3.peg.1104
Escherichia coli MS 198-1
M
L
ST
Q
F
NRDNQ
H
Q
T
TS
KPS
L
LA
A
CI
A
LAL
L
P
S
A
A
F
A
A
P
ATE
ETVIV
EG
SA
T
---
AP
D
D
GEN
DY
S
V
T
ST
------
SAGTKMQM
T
QR
DIPQSVT
I
VS
Q
Q
R
ME
D
QQ
LQ
TL
G
EV
M
E
NT
L
G
I
---
-
-
S
K
S
Q
A
D
S
D
R
A
LYY
SRGF
------
QI
DNYM
--
V
DGI
P
T
YFESR
WNLGDA
LS
DM
-
AL
F
ERVEVVRG
A
T
G
L
M
T
G
TG
NP
SA
AINMV
R
K
H
AT
SRE
------------
FKGDVSAEYGS
W
NK
ER
Y
VA
D
L
Q
SP
L
TE
DG
KIR
ARIVG
GY
QN
N
D
S
W
LDRYN
SE
K
TF
------
FSG
IV
D
A
DL
G
DL
T
T
LSAG
YEY
Q
RIDVNS
P
T
WGG
----
LP
RW
N
T
D
-----
GS
S
N
SYDR
AR
ST
AP
D
WAY
ND
K
EI
N
--------
K
V
FM
TLK
Q
R
FADTWQAT
L
N
AT
HSE
V
EFD
SKMMY
V
D
AY
VNKADGMLVGPYSNYGPGF
DY
V
G
GTG
WN
S
G
---------------------------
-
-
K
R
K
VDA
-------
--
-
--
-
-
---
-
L
D
LF
A
DG
SY
EL
FGR
QH
N
LMFGG
----------
SYSK
QN
N
RYFSSWANIFPD
EI
GSF
Y
N
FN
GN
F
P
QT
D
-
-
--
W
SP
-------------
----
---
------------QS
L
A
QDD
T
TH
M
KS
L
YAA
T
RVT
L
A
D
PLHLI
LG
A
R
-------
Y
----
--
-TNW
R
--------------
VDTLTY
-----
SM
EK
N
HT
----
TP
YA
GLVF
D
I
N
DNWS
T
YASYT
S
I
FQP
---------
Q
N
-
DR
D
SS
G
KY
-
L
A
P
I
TGNNYE
-------
LGLK
SDWM
N
SR
LT
T
T
L
AIF
R
I
E
Q
D
NVA
Q
S
---
T
GT
P
I
PGSN
GE
T
AYKAVDGTV
SKGVE
F
ELN
---
GA
I
T
D
NWQL
TF
GA
T
R
Y
I
AE
DN
-------
E
G
N
A
VN
PNLP
-----
RTTVKMF
T
SY
R
L
P
VMP
E
---
LT
V
G
-----
GGV
N
W
QN
--
R
VY
TDT
VT
PY
G
-
TFR
A
EQ
GSYALVDLFTRY
Q
VTK
----
NF
SLQGNVNNLFDKTY
D
TN
VE
GSIVY
-
--
-
GAPR
N
F
SI
TGTYQF
fig|585056.7.peg.1483
Escherichia coli UMN026
M
L
ST
Q
F
NRDNQ
H
Q
T
TS
KPS
L
LA
A
CI
A
LAL
L
P
S
A
A
F
A
A
P
ATE
ETVIV
EG
SA
T
---
AP
D
D
GEN
DY
S
V
T
ST
------
SAGTKMQM
T
QR
DIPQSVT
I
VS
Q
Q
R
ME
D
QQ
LQ
TL
G
EV
M
E
NT
L
G
I
---
-
-
S
K
S
Q
A
D
S
D
R
A
LYY
SRGF
------
QI
DNYM
--
V
DGI
P
T
YFESR
WNLGDA
LS
DM
-
AL
F
ERVEVVRG
A
T
G
L
M
T
G
TG
NP
SA
AINMV
R
K
H
AT
SRE
------------
FKGDVSAEYGS
W
NK
ER
Y
VA
D
L
Q
SP
L
TE
DG
KIR
ARIVG
GY
QN
N
D
S
W
LDRYN
SE
K
TF
------
FSG
IV
D
A
DL
G
DL
T
T
LSAG
YEY
Q
RIDVNS
P
T
WGG
----
LP
RW
N
T
D
-----
GS
S
N
SYDR
AR
ST
AP
D
WAY
ND
K
EI
N
--------
K
V
FM
TLK
Q
R
FADTWQAT
L
N
AT
HSE
V
EFD
SKMMY
V
D
AY
VNKADGMLVGPYSNYGPGF
DY
V
G
GTG
WN
S
G
---------------------------
-
-
K
R
K
VDA
-------
--
-
--
-
-
---
-
L
D
LF
A
DG
SY
EL
FGR
QH
N
LMFGG
----------
SYSK
QN
N
RYFSSWANIFPD
EI
GSF
Y
N
FN
GN
F
P
QT
D
-
-
--
W
SP
-------------
----
---
------------QS
L
A
QDD
T
TH
M
KS
L
YAA
T
RVT
L
A
D
PLHLI
LG
A
R
-------
Y
----
--
-TNW
R
--------------
VDTLTY
-----
SM
EK
N
HT
----
TP
YA
GLVF
D
I
N
DNWS
T
YASYT
S
I
FQP
---------
Q
N
-
DR
D
SS
G
KY
-
L
A
P
I
TGNNYE
-------
LGLK
SDWM
N
SR
LT
T
T
L
AIF
R
I
E
Q
D
NVA
Q
S
---
T
GT
P
I
PGSN
GE
T
AYKAVDGTV
SKGVE
F
ELN
---
GA
I
T
D
NWQL
TF
GA
T
R
Y
I
AE
DN
-------
E
G
N
A
VN
PNLP
-----
RTTVKMF
T
SY
R
L
P
VMP
E
---
LT
V
G
-----
GGV
N
W
QN
--
R
VY
TDT
VT
PY
G
-
TFR
A
EQ
GSYALVDLFTRY
Q
VTK
----
NF
SLQGNVNNLFDKTY
D
TN
VE
GSIVY
-
--
-
GAPR
N
F
SI
TGTYQF
fig|550677.3.peg.2545
Escherichia coli B354
M
L
ST
Q
F
NRDNQ
H
Q
T
TS
KPS
L
LA
A
CI
A
LAL
L
P
S
A
A
F
A
A
P
ATE
ETVIV
EG
SA
T
---
T
P
V
D
DEN
DY
S
V
T
ST
------
SAGTKMQM
T
QR
DIPQSVT
I
VS
Q
Q
R
ME
D
QQ
LQ
TL
G
EV
M
E
NT
L
G
I
---
-
-
S
K
S
Q
A
D
S
D
R
A
LYY
SRGF
------
QI
DNYM
--
V
DGI
P
T
YFESR
WNLGDA
LS
DM
-
AL
F
ERVEVVRG
A
T
G
L
M
T
G
TG
NP
SA
AINMV
R
K
H
AT
SRE
------------
FKGDVSAEYGS
W
NK
ER
Y
VA
D
L
Q
SP
L
TE
DG
KIR
ARIVG
GY
QN
N
D
S
W
LDRYN
SE
K
TF
------
FSG
IV
D
A
DL
G
DL
T
T
LSAG
YEY
Q
RIDVNS
P
T
WGG
----
LP
RW
N
T
D
-----
GS
S
N
SYDR
AR
ST
AP
D
WAY
ND
K
EI
N
--------
K
V
FM
TLK
Q
R
FADTWQAT
L
N
AT
HSE
V
EFD
SKMMY
V
D
AY
VNKADGMLVGPYSNYGPGF
DY
V
G
GTG
WN
S
G
---------------------------
-
-
K
R
K
VDA
-------
--
-
--
-
-
---
-
L
D
LF
A
DG
SY
EL
FGR
QH
N
LMFGG
----------
SYSK
QN
N
RYFSSWANIFPD
EI
GSF
Y
N
FN
GN
F
P
QT
D
-
-
--
W
SP
-------------
----
---
------------QS
L
A
QDD
T
TH
M
KS
L
YAA
T
RVT
L
A
D
PLHLI
LG
A
R
-------
Y
----
--
-TNW
R
--------------
VDTLTY
-----
SM
EK
N
HT
----
TP
YA
GLVF
D
I
N
DNWS
T
YASYT
S
I
FQP
---------
Q
N
-
DR
D
SS
G
KY
-
L
A
P
I
TGNNYE
-------
LGLK
SDWM
N
SR
LT
T
T
L
AIF
R
I
E
Q
D
NVA
Q
S
---
T
GT
P
I
PGSN
GE
T
AYKAVDGTV
SKGVE
F
ELN
---
GA
I
T
D
NWQL
TF
GA
T
R
Y
I
AE
DN
-------
E
G
N
A
VN
PNLP
-----
RTTVKMF
T
SY
R
L
P
VMP
E
---
LT
V
G
-----
GGV
N
W
QN
--
R
VY
TDT
VT
PY
G
-
TFR
A
EQ
GSYALVDLFTRY
Q
VTK
----
NF
SLQGNVNNLFDKTY
D
TN
VE
GSIVY
-
--
-
GAPR
N
F
SI
TGTYQF
fig|656393.3.peg.1877
Escherichia coli H299
M
L
ST
Q
F
NRDNQ
Y
Q
T
TS
KPS
L
LA
A
CI
A
LAL
L
P
S
A
A
F
A
A
P
ATE
ETVIV
EG
SA
T
---
T
P
V
D
DEN
DY
S
V
T
ST
------
SAGTKMQM
T
QR
DIPQSVT
I
VS
Q
Q
R
ME
D
QQ
LQ
TL
G
EV
M
E
NT
L
G
I
---
-
-
S
K
S
Q
A
D
S
D
R
A
LYY
SRGF
------
QI
DNYM
--
V
DGI
P
T
YFESR
WNLGDA
LS
DM
-
AL
F
ERVEVVRG
A
T
G
L
M
T
G
TG
NP
SA
AINMV
R
K
H
AT
SRE
------------
FKGDVSAEYGS
W
NK
ER
Y
VA
D
L
Q
SP
L
TE
DG
KIR
ARIVG
GY
QN
N
D
S
W
LDRYN
SE
K
TF
------
FSG
IV
D
A
DL
G
DL
T
T
LSAG
YEY
Q
RIDVNS
P
T
WGG
----
LP
RW
N
T
D
-----
GS
S
N
SYDR
AR
ST
AP
D
WAY
ND
K
EI
N
--------
K
V
FM
TLK
Q
R
FADTWQAT
L
N
AT
HSE
V
EFD
SKMMY
V
D
AY
VNKADGMLVGPYSNYGPGF
DY
V
G
GTG
WN
S
G
---------------------------
-
-
K
R
K
VDA
-------
--
-
--
-
-
---
-
L
D
LF
A
DG
SY
EL
FGR
QH
N
LMFGG
----------
SYSK
QN
N
RYFSSWA
Y
IFPD
EI
GSF
Y
N
FN
GN
F
P
QT
D
-
-
--
W
SP
-------------
----
---
------------QS
L
A
QDD
T
TH
M
KS
L
YAA
T
RVT
L
A
D
PLHLI
LG
A
R
-------
Y
----
--
-TNW
R
--------------
VDTLTY
-----
SM
EK
N
HT
----
TP
YA
GLVF
D
I
N
DNWS
T
YASYT
S
I
FQP
---------
Q
N
-
DR
D
SS
G
KY
-
L
A
P
I
TGNNYE
-------
LGLK
SDWM
N
SR
LT
T
T
L
AIF
R
I
E
Q
D
NVA
Q
S
---
T
GT
P
I
PGSN
GE
T
AYKAVDGTV
SKGVE
F
ELN
---
GA
I
T
D
NWQL
TF
GA
T
R
Y
I
AE
DN
-------
E
G
N
A
VN
PNLP
-----
RTTVKMF
T
SY
R
L
P
VMP
E
---
LT
V
G
-----
GGV
N
W
QN
--
R
VY
TDT
VT
PY
G
-
TFR
A
EQ
GSYALVDLFTRY
Q
VTK
----
NF
SLQGNVNNLFDKTY
D
TN
VE
GSIVY
-
--
-
GAPR
N
F
SI
TGTYQF
fig|670897.3.peg.4473
Escherichia coli 2362-75
M
L
ST
Q
F
NRDNQ
H
Q
T
TS
KPS
L
LA
A
CI
A
LAL
L
P
S
A
A
F
A
A
P
ATE
ETVIV
EG
SA
T
---
T
P
V
D
DEN
DY
S
V
T
ST
------
SAGTKMQM
T
QR
DIPQSVT
I
VS
Q
Q
R
ME
D
QQ
LQ
TL
G
EV
M
E
NT
L
G
I
---
-
-
S
K
S
Q
A
D
S
D
R
A
LYY
SRGF
------
QI
DNYM
--
V
DGI
P
T
YFESR
WNLGDA
LS
DM
-
AL
F
ERVEVVRG
A
T
G
L
M
T
G
TG
NP
SA
AINMV
R
K
H
AT
SRE
------------
FKGDVSAEYGS
W
NK
ER
Y
VA
D
L
Q
SP
L
TE
DG
KIR
ARIVG
GY
QN
N
D
S
W
LDRYN
SE
K
TF
------
FSG
IV
D
A
DL
G
DL
T
T
LSAG
YEY
Q
RIDVNS
P
T
WGG
----
LP
RW
N
T
D
-----
GS
G
N
SYDR
AR
ST
AP
D
WAY
ND
K
EI
N
--------
K
V
FM
TLK
Q
R
FADTWQAT
L
N
AT
HSE
V
EFD
SKMMY
V
D
AY
VNKADGMLVGPYSNYGPGF
DY
V
G
GTG
WN
S
G
---------------------------
-
-
K
R
K
VDA
-------
--
-
--
-
-
---
-
L
D
LF
A
DG
SY
EL
FGR
QH
N
LMFGG
----------
SYSK
QN
N
RYFSSWANIFPD
EI
GSF
Y
N
FN
GN
F
P
QT
D
-
-
--
W
SP
-------------
----
---
------------QS
L
A
QDD
T
TH
M
KS
L
YAA
T
RVT
L
A
D
PLHLI
LG
A
R
-------
Y
----
--
-TNW
R
--------------
VDTLTY
-----
SM
EK
N
HT
----
TP
YA
GLVF
D
I
N
DNWS
T
YASYT
S
I
FQP
---------
Q
K
-
DR
D
SS
G
KY
-
L
A
P
I
TGNNYE
-------
LGLK
SDWM
N
SR
LT
T
T
L
AIF
R
I
E
Q
D
NVA
Q
S
---
T
GT
P
I
PGSN
GE
T
AYKAVDGTV
SKGVE
F
ELN
---
GA
I
T
D
NWQL
TF
GA
T
R
Y
I
AE
DN
-------
E
G
N
A
VN
PNLP
-----
RTT
I
KMF
T
SY
R
L
P
VMP
E
---
LT
V
G
-----
GGV
N
W
QN
--
R
VY
TDT
VT
PY
G
-
TFR
A
EQ
GSYALVDLFTRY
Q
VTK
----
NF
SLQGNVNNLFDKTY
D
TN
VE
GSIVY
-
--
-
GAPR
N
F
SI
TGTYQF
fig|216593.1.peg.917
Escherichia coli E2348/69
M
L
ST
Q
F
NRDNQ
H
Q
T
TS
KPS
L
LA
A
CI
A
LAL
L
P
S
A
A
F
A
A
P
ATE
ETVIV
EG
SA
T
---
T
P
V
D
DEN
DY
S
V
T
ST
------
SAGTKMQM
T
QR
DIPQSVT
I
VS
Q
Q
R
ME
D
QQ
LQ
TL
G
EV
M
E
NT
L
G
I
---
-
-
S
K
S
Q
A
D
S
D
R
A
LYY
SRGF
------
QI
DNYM
--
V
DGI
P
T
YFESR
WNLGDA
LS
DM
-
AL
F
ERVEVVRG
A
T
G
L
M
T
G
TG
NP
SA
AINMV
R
K
H
AT
SRE
------------
FKGDVSAEYGS
W
NK
ER
Y
VA
D
L
Q
SP
L
TE
DG
KIR
ARIVG
GY
QN
N
D
S
W
LDRYN
SE
K
TF
------
FSG
IV
D
A
DL
G
DL
T
T
LSAG
YEY
Q
RIDVNS
P
T
WGG
----
LP
RW
N
T
D
-----
GS
G
N
SYDR
AR
ST
AP
D
WAY
ND
K
EI
N
--------
K
V
FM
TLK
Q
R
FADTWQAT
L
N
AT
HSE
V
EFD
SKMMY
V
D
AY
VNKADGMLVGPYSNYGPGF
DY
V
G
GTG
WN
S
G
---------------------------
-
-
K
R
K
VDA
-------
--
-
--
-
-
---
-
L
D
LF
A
DG
SY
EL
FGR
QH
N
LMFGG
----------
SYSK
QN
N
RYFSSWANIFPD
EI
GSF
Y
N
FN
GN
F
P
QT
D
-
-
--
W
SP
-------------
----
---
------------QS
L
A
QDD
T
TH
M
KS
L
YAA
T
RVT
L
A
D
PLHLI
LG
A
R
-------
Y
----
--
-TNW
R
--------------
VDTLTY
-----
SM
EK
N
HT
----
TP
YA
GLVF
D
I
N
DNWS
T
YASYT
S
I
FQP
---------
Q
K
-
DR
D
SS
G
KY
-
L
A
P
I
TGNNYE
-------
LGLK
SDWM
N
SR
LT
T
T
L
AIF
R
I
E
Q
D
NVA
Q
S
---
T
GT
P
I
PGSN
GE
T
AYKAVDGTV
SKGVE
F
ELN
---
GA
I
T
D
NWQL
TF
GA
T
R
Y
I
AE
DN
-------
E
G
N
A
VN
PNLP
-----
RTT
I
KMF
T
SY
R
L
P
VMP
E
---
LT
V
G
-----
GGV
N
W
QN
--
R
VY
TDT
VT
PY
G
-
TFR
A
EQ
GSYALVDLFTRY
Q
VTK
----
NF
SLQGNVNNLFDKTY
D
TN
VE
GSIVY
-
--
-
GAPR
N
F
SI
TGTYQF
fig|749531.3.peg.3026
Escherichia coli MS 69-1
M
L
ST
Q
F
NRDNQ
Y
Q
T
TS
KPS
L
LA
A
CI
A
LAL
L
P
S
A
A
F
A
A
P
ATE
ETVIV
EG
SA
T
---
T
P
V
D
DEN
DY
S
V
T
ST
------
SAGTKMQM
T
QR
DIPQSVT
I
VS
Q
Q
R
ME
D
QQ
LQ
TL
G
EV
M
E
NT
L
G
I
---
-
-
S
K
S
Q
A
D
S
D
R
A
LYY
SRGF
------
QI
DNYM
--
V
DGI
P
T
YFESR
WNLGDA
LS
DM
-
AL
F
ERVEVVRG
A
T
G
L
M
T
G
TG
NP
SA
AINMV
R
K
H
AT
SRE
------------
FKGDVSAEYGS
W
NK
ER
Y
VA
D
I
Q
SP
L
TE
DG
KIR
ARIVG
GY
QN
N
D
S
W
LDRYN
SE
K
TF
------
FSG
IV
D
A
DL
G
DL
T
M
LSAG
YEY
Q
RIDVNS
P
T
WGG
----
LP
RW
N
T
D
-----
GS
S
N
SYDR
AR
ST
AP
D
WAY
ND
K
EI
N
--------
K
V
FM
TLK
Q
R
FADTWQAT
L
N
AT
HSE
V
EFD
SKMMY
V
D
AY
VNKADGMLVGPYSNYGPGF
DY
V
G
GTG
WN
S
G
---------------------------
-
-
K
R
K
VDA
-------
--
-
--
-
-
---
-
L
D
LF
A
DG
SY
EL
FGR
QH
N
LMFGG
----------
SYSK
QN
N
RYFSSWANIFPD
EI
GSF
Y
N
FN
GN
F
P
QT
D
-
-
--
W
SP
-------------
----
---
------------QS
L
A
QDD
T
TH
M
KS
L
YAA
T
RVT
L
A
D
PLHLI
LG
A
R
-------
Y
----
--
-TNW
R
--------------
VDTLTY
-----
SM
EK
N
HT
----
TP
YA
GLVF
D
I
N
DNWS
T
YASYT
S
I
FQP
---------
Q
N
-
DR
D
SS
G
KY
-
L
A
P
I
TGNNYE
-------
LGLK
SDWM
N
SR
LT
T
T
L
AIF
R
I
E
Q
D
NVA
Q
S
---
T
GT
P
I
PGSN
G
K
T
AYKAVDGTV
SKGVE
F
ELN
---
GA
I
T
D
NWQL
TF
GA
T
R
Y
I
AE
DN
-------
E
G
N
A
VN
PNLP
-----
RTTVKMF
T
SY
R
L
P
VMP
E
---
LT
V
G
-----
GGV
N
W
QN
--
R
VY
TDT
VT
PY
D
-
TFR
A
EQ
GSYALVDLFTRY
Q
VTK
----
NF
SLQGNVNNLFDKTY
D
TN
VE
GSIVY
-
--
-
GAPR
N
F
SI
TGTYQF
fig|340197.3.peg.2624
Escherichia coli F11 (2-713/713)
A
M
F
T
P
S
F
-----
-
SG
LK
GRA
L
FSLLF
A
APM
I
H
A
T
D
S
V
T
T
KDG
ET
IT
VTA
D
A
N
---
T
A
T
E
ATD
G
Y
Q
P
L
ST
------
S
T
A
T
L
TD
MP
ML
DIPQ
V
V
NT
VS
D
Q
V
L
E
N
Q
N
AT
TL
D
E
A
L
-
Y
NVSN
---
V
V
Q
T
N
TLG
G
T
Q
D
AFV
R
RGF
----
G
A
NR
D
G
S
I
-
M
T
N
G
L
R
T
VLPRS
F
N
--
A
A
T-
--
-
--
-
ERVEV
LK
GP
A
S
T
L
YG
IL
D
PGG
L
IN
V
V
T
KR
P
E
KTF
HGS
V
SATSSS
--
F
G
G
------
G
T
G
Q
L
--
-
--
D
I
T
GP
I
EG
T
-
QLA
Y
R
LT
G
EV
Q
D
E
D
Y
W
RNFGK
E
R
S
TF
IAP
S
--
L
TW
FG
D
-
N
A
T
-V
T
M
L
-
Y
-
SHR
D
------
Y
K
T
PF
----
--
DR
GT
I
FDLTT
KQ
P
V
N
V
DR
KI
RF
DE
P
FNI
T
DG
QS
D
--------
L
A
QL
NA
EY
H
L
N
SQ
W
T
A
R
F
D
YS
Y
S
Q
D
K
Y
SDNQAR
V
T
AY
-------------------
DA
T
T
G
--
--
-
-
---------------------------
T
L
T
R
R
VDA
T
------
QG
S
TQ
R
M
HAT
R
A
D
--
L
Q
G
NV
DI
AGF
Y
N
E
I
L
G
G
V
SYEYYDLLRT
D
MI
R
CK
K
----------
AK
D
F
N--
--
--
--
-
-
--
-
-
I
--
Y
N
P
-------------
VYGN
---
TSKCTTVSASDSDQ
T
I
KQ
E
S
Y
-
-
-
S
A
YA
Q
D
ALY
L
T
D
NWIAV
A
G
I
R
-------
Y
QYYT
Q
Y
AGKG
R
--------------
PFNVNT
-----
DS
R
D
E
Q
W
----
TP
KL
GLV
Y
K
L
T
P
S
V
S
L
F
A
N
Y
S
Q
T
F
M
P
---------
Q
S
S
IA
S
YI
G
DL
-
-
P
P
E
S
S
N
A
YE
-------
V
G
A
K
FELF
D
G-
I
T
A
D
I
A
L
F
D
I
H
K
R
NV
L
Y
T
ESV
G
D
E
T
I
AKTA
G
R
V
R
--------
S
R
GVE
V
D
L
A
---
GALT
E
N
I
N
I
IA
SY
G
Y
T
DA
K
VL
--
E
D
PD
Y
A
G
-
K
PL
PN
I
P
-----
R
H
T
G
SL
F
L
T
Y
D
I
H
N
MP
G
NNT
LT
F
G
-----
GG
G
HG
VS
RR
S
A-
---
TN
G
A
D
-
-
Y
Y
L
--
P
G
Y
F
VA
D
A
F
A
A
Y
K
M
-
K
LQYP
-V
T
LQ
L
NV
K
NLFDKTY
Y
T
S
SI
A
T
N
NL
G
NQ
I
G
D
PR
E
V
QF
T
VKM
E
F
fig|749550.3.peg.4087
Escherichia coli MS 200-1 (2-713/713)
A
M
F
T
P
S
F
-----
-
SG
LK
GRA
L
FSLLF
A
APM
I
H
A
T
D
S
V
T
T
KDG
ET
IT
VTA
D
A
N
---
T
A
T
E
ATD
G
Y
Q
P
L
ST
------
S
T
A
T
L
TD
MP
ML
DIPQ
V
V
NT
VS
D
Q
V
L
E
N
Q
N
AT
TL
D
E
A
L
-
Y
NVSN
---
V
V
Q
T
N
TLG
G
T
Q
D
AFV
R
RGF
----
G
A
NR
D
G
S
I
-
M
T
N
G
L
R
T
VLPRS
F
N
--
A
A
T-
--
-
--
-
ERVEV
LK
GP
A
S
T
L
YG
IL
D
PGG
L
IN
V
V
T
KR
P
E
KTF
HGS
V
SATSSS
--
F
G
G
------
G
T
G
Q
L
--
-
--
D
I
T
GP
I
EG
T
-
QLA
Y
R
LT
G
EV
Q
D
E
D
Y
W
RNFGK
E
R
S
TF
IAP
S
--
L
TW
FG
D
-
N
A
T
-V
T
M
L
-
Y
-
SHR
D
------
Y
K
T
PF
----
--
DR
GT
I
FDLTT
KQ
P
V
N
V
DR
KI
RF
DE
P
FNI
T
DG
QS
D
--------
L
A
QL
NA
EY
H
L
N
SQ
W
T
A
R
F
D
YS
Y
S
Q
D
K
Y
SDNQAR
V
T
AY
-------------------
DA
T
T
G
--
--
-
-
---------------------------
T
L
T
R
R
VDA
T
------
QG
S
TQ
R
M
HAT
R
A
D
--
L
Q
G
NV
DI
AGF
Y
N
E
I
L
G
G
V
SYEYYDLLRT
D
MI
R
CK
K
----------
AK
D
F
N--
--
--
--
-
-
--
-
-
I
--
Y
N
P
-------------
VYGN
---
TSKCTTVSASDSDQ
T
I
KQ
E
S
Y
-
-
-
S
A
YA
Q
D
ALY
L
T
D
NWIAV
A
G
I
R
-------
Y
QYYT
Q
Y
AGKG
R
--------------
PFNVNT
-----
DS
R
D
E
Q
W
----
TP
KL
GLV
Y
K
L
T
P
S
V
S
L
F
A
N
Y
S
Q
T
F
M
P
---------
Q
S
S
IA
S
YI
G
DL
-
-
P
P
E
S
S
N
A
YE
-------
V
G
A
K
FELF
D
G-
I
T
A
D
I
A
L
F
D
I
H
K
R
NV
L
Y
T
ESV
G
D
E
T
I
AKTA
G
R
V
R
--------
S
R
GVE
V
D
L
A
---
GALT
E
N
I
N
I
IA
SY
G
Y
T
DA
K
VL
--
E
D
PD
Y
A
G
-
K
PL
PN
I
P
-----
R
H
T
G
SL
F
L
T
Y
D
I
H
N
MP
G
NNT
LT
F
G
-----
GG
G
HG
VS
RR
S
A-
---
TN
G
A
D
-
-
Y
Y
L
--
P
G
Y
F
VA
D
A
F
A
A
Y
K
M
-
K
LQYP
-V
T
LQ
L
NV
K
NLFDKTY
Y
T
S
SI
A
T
N
NL
G
NQ
I
G
D
PR
E
V
QF
T
VKM
E
F
fig|562.376.peg.3892
Escherichia coli WV_060327 (2-713/713)
A
M
F
T
P
S
F
-----
-
SG
LK
GRA
L
FSLLF
A
APM
I
H
A
T
D
S
V
T
T
KDG
ET
IT
VTA
D
A
N
---
S
A
T
E
ATD
G
Y
Q
P
L
ST
------
S
T
A
T
L
TD
MP
ML
DIPQ
V
V
NT
VS
D
Q
V
L
E
N
Q
N
AT
TL
D
E
A
L
-
Y
NVSN
---
V
V
Q
T
N
TLG
G
T
Q
D
AFV
R
RGF
----
G
A
NR
D
G
S
I
-
M
T
N
G
L
R
T
VLPRS
F
N
--
A
A
T-
--
-
--
-
ERVEV
LK
GP
A
S
T
L
YG
IL
D
PGG
L
IN
V
V
T
KR
P
E
KTF
HGS
V
SATSSS
--
F
G
G
------
G
T
G
Q
L
--
-
--
D
I
T
GP
I
EG
T
-
QLA
Y
R
LT
G
EV
Q
D
E
D
Y
W
RNFGK
E
R
S
TF
IAP
S
--
L
TW
FG
D
-
N
A
T
-V
T
M
L
-
Y
-
SHR
D
------
Y
K
T
PF
----
--
DR
GT
I
FDLTT
KQ
P
V
N
V
DR
KI
RF
DE
P
FNI
T
DG
QS
D
--------
L
A
QL
NA
EY
H
L
N
SQ
W
T
A
R
F
D
YS
Y
S
Q
D
K
Y
SDNQAR
V
T
AY
-------------------
DA
T
T
G
--
--
-
-
---------------------------
T
L
T
R
R
VDA
T
------
QG
S
TQ
R
M
HAT
R
A
D
--
L
Q
G
NV
DI
AGF
Y
N
E
I
L
G
G
V
SYEYYDLLRT
D
MI
R
CK
K
----------
AK
D
F
N--
--
--
--
-
-
--
-
-
I
--
Y
N
P
-------------
VYGN
---
TSKCTTVSASDSDQ
T
I
KQ
E
S
Y
-
-
-
S
A
YA
Q
D
ALY
L
T
D
NWIAV
A
G
I
R
-------
Y
QYYT
Q
Y
AGKG
R
--------------
PFNVNT
-----
DS
R
D
E
Q
W
----
TP
KL
GLV
Y
K
L
T
P
S
V
S
L
F
A
N
Y
S
Q
T
F
M
P
---------
Q
S
S
IA
S
YI
G
DL
-
-
P
P
E
S
S
N
A
YE
-------
V
G
A
K
FELF
D
G-
I
T
A
D
I
A
L
F
D
I
H
K
R
NV
L
Y
T
ESI
G
D
E
T
I
AKTA
G
R
V
R
--------
S
R
GVE
V
D
L
A
---
GALT
E
N
I
N
I
IA
SY
G
Y
T
DA
K
VL
--
E
D
PD
Y
A
G
-
K
PL
PN
V
P
-----
R
H
T
G
SL
F
L
T
Y
D
I
H
N
MP
G
NNT
LT
F
G
-----
GG
G
HG
VS
RR
S
A-
---
TN
G
A
D
-
-
Y
Y
L
--
P
G
Y
F
VA
D
A
F
A
A
Y
K
M
-
K
LQYP
-V
T
LQ
L
NV
K
NLFDKTY
Y
T
S
SI
A
T
N
NL
G
NQ
I
G
D
PR
E
V
QF
T
VKM
E
F
fig|670897.3.peg.4288
Escherichia coli 2362-75 (2-713/713)
A
M
F
T
P
S
F
-----
-
SG
LK
GRA
L
FSLLF
A
APM
I
H
A
T
D
S
V
T
T
KDG
ET
IT
VTA
D
A
N
---
T
A
T
E
ATD
G
Y
Q
P
L
ST
------
S
T
A
T
L
TD
MP
ML
DIPQ
V
V
NT
VS
D
Q
V
L
E
N
Q
N
AT
TL
D
E
A
L
-
Y
NVSN
---
V
V
Q
T
N
TLG
G
T
Q
D
AFV
R
RGF
----
G
A
NR
D
G
S
I
-
M
T
N
G
L
R
T
VLPRS
F
N
--
A
A
T-
--
-
--
-
ERVEV
LK
GP
A
S
T
L
YG
IL
D
PGG
L
IN
V
V
T
KR
P
E
KTF
HGS
V
SATSSS
--
F
G
G
------
G
T
G
Q
L
--
-
--
D
I
T
GP
I
EG
T
-
QLA
Y
R
LT
G
EV
Q
D
E
D
Y
W
RNFGK
E
R
S
TF
IAP
S
--
L
TW
FG
D
-
N
A
T
-V
T
M
L
-
Y
-
SHR
D
------
Y
K
T
PF
----
--
DR
GT
I
FDLTT
KQ
P
V
N
V
DR
KI
RF
DE
P
FNI
T
DG
QS
D
--------
L
A
QL
NA
EY
H
L
N
SQ
W
T
A
R
F
D
YS
Y
S
Q
D
K
Y
SDNQAR
V
T
AY
-------------------
DA
T
T
G
--
--
-
-
---------------------------
T
L
T
R
R
VDA
T
------
QG
S
TQ
R
M
HAT
R
A
D
--
L
Q
G
NV
DI
AGF
Y
N
E
I
L
G
G
V
SYEYYDLLRT
D
MI
R
CK
K
----------
AK
D
F
N--
--
--
--
-
-
--
-
-
I
--
Y
N
P
-------------
VYGN
---
TSKCTTVSASDSDQ
T
I
KQ
E
S
Y
-
-
-
S
A
YA
Q
D
ALY
L
T
D
NWIAV
A
G
I
R
-------
Y
QYYT
Q
Y
AGKG
R
--------------
PFNVNT
-----
DS
R
D
E
Q
W
----
TP
KL
GLV
Y
K
L
T
P
S
V
S
L
F
A
N
Y
S
Q
T
F
M
P
---------
Q
S
S
IA
S
YI
G
DL
-
-
P
P
E
S
S
N
A
YE
-------
V
G
A
K
FELF
D
G-
I
T
A
D
I
A
L
F
D
I
H
K
R
NV
L
Y
T
ESV
G
D
E
T
I
AKTA
G
R
V
R
--------
S
R
GVE
V
D
L
A
---
GALT
E
N
I
N
I
IA
SY
G
Y
T
DA
K
VL
--
E
D
PD
Y
A
G
-
K
PL
PN
V
P
-----
R
H
T
G
SL
F
L
T
Y
D
I
H
N
MP
G
NNT
LT
F
G
-----
GG
G
HG
VS
RR
S
A-
---
TN
G
A
D
-
-
Y
Y
L
--
P
G
Y
F
VA
D
A
F
A
A
Y
K
M
-
K
LQYP
-V
T
LQ
L
NV
K
NLFDKTY
Y
T
S
SI
A
T
N
NL
G
NQ
I
G
D
PR
E
V
QF
T
VKM
E
F
fig|216593.1.peg.5112
Escherichia coli E2348/69 (2-713/713)
A
M
F
T
P
S
F
-----
-
SG
LK
GRA
L
FSLLF
A
APM
I
H
A
T
D
S
V
T
T
KDG
ET
IT
VTA
D
A
N
---
T
A
T
E
ATD
G
Y
Q
P
L
ST
------
S
T
A
T
L
TD
MP
ML
DIPQ
V
V
NT
VS
D
Q
V
L
E
N
Q
N
AT
TL
D
E
A
L
-
Y
NVSN
---
V
V
Q
T
N
TLG
G
T
Q
D
AFV
R
RGF
----
G
A
NR
D
G
S
I
-
M
T
N
G
L
R
T
VLPRS
F
N
--
A
A
T-
--
-
--
-
ERVEV
LK
GP
A
S
T
L
YG
IL
D
PGG
L
IN
V
V
T
KR
P
E
KTF
HGS
V
SATSSS
--
F
G
G
------
G
T
G
Q
L
--
-
--
D
I
T
GP
I
EG
T
-
QLA
Y
R
LT
G
EV
Q
D
E
D
Y
W
RNFGK
E
R
S
TF
IAP
S
--
L
TW
FG
D
-
N
A
T
-V
T
M
L
-
Y
-
SHR
D
------
Y
K
T
PF
----
--
DR
GT
I
FDLTT
KQ
P
V
N
V
DR
KI
RF
DE
P
FNI
T
DG
QS
D
--------
L
A
QL
NA
EY
H
L
N
SQ
W
T
A
R
F
D
YS
Y
S
Q
D
K
Y
SDNQAR
V
T
AY
-------------------
DA
T
T
G
--
--
-
-
---------------------------
T
L
T
R
R
VDA
T
------
QG
S
TQ
R
M
HAT
R
A
D
--
L
Q
G
NV
DI
AGF
Y
N
E
I
L
G
G
V
SYEYYDLLRT
D
MI
R
CK
K
----------
AK
D
F
N--
--
--
--
-
-
--
-
-
I
--
Y
N
P
-------------
VYGN
---
TSKCTTVSASDSDQ
T
I
KQ
E
S
Y
-
-
-
S
A
YA
Q
D
ALY
L
T
D
NWIAV
A
G
I
R
-------
Y
QYYT
Q
Y
AGKG
R
--------------
PFNVNT
-----
DS
R
D
E
Q
W
----
TP
KL
GLV
Y
K
L
T
P
S
V
S
L
F
A
N
Y
S
Q
T
F
M
P
---------
Q
S
S
IA
S
YI
G
DL
-
-
P
P
E
S
S
N
A
YE
-------
V
G
A
K
FELF
D
G-
I
T
A
D
I
A
L
F
D
I
H
K
R
NV
L
Y
T
ESV
G
D
E
T
I
AKTA
G
R
V
R
--------
S
R
GVE
V
D
L
A
---
GALT
E
N
I
N
I
IA
SY
G
Y
T
DA
K
VL
--
E
D
PD
Y
A
G
-
K
PL
PN
V
P
-----
R
H
T
G
SL
F
L
T
Y
D
I
H
N
MP
G
NNT
LT
F
G
-----
GG
G
HG
VS
RR
S
A-
---
TN
G
A
D
-
-
Y
Y
L
--
P
G
Y
F
VA
D
A
F
A
A
Y
K
M
-
K
LQYP
-V
T
LQ
L
NV
K
NLFDKTY
Y
T
S
SI
A
T
N
NL
G
NQ
I
G
D
PR
E
V
QF
T
VKM
E
F
fig|656417.3.peg.3862
Escherichia coli M605 (2-713/713)
A
M
F
T
P
S
F
-----
-
SG
LK
GRA
L
FSLLF
A
APM
I
H
A
T
D
S
V
T
T
KDG
ET
IT
VTA
D
A
N
---
T
A
T
E
ATD
G
Y
Q
P
L
ST
------
S
T
A
T
L
TD
MP
ML
DIPQ
V
V
NT
VS
D
Q
V
L
E
N
Q
N
AT
TL
D
E
A
L
-
Y
NVSN
---
V
V
Q
T
N
TLG
G
T
Q
D
AFV
R
RGF
----
G
A
NR
D
G
S
I
-
M
T
N
G
L
R
T
VLPRS
F
N
--
A
A
T-
--
-
--
-
ERVEV
LK
GP
A
S
T
L
YG
IL
D
PGG
L
IN
V
V
T
KR
P
E
KTF
HGS
V
SATSSS
--
F
G
G
------
G
T
G
Q
L
--
-
--
D
I
T
GP
I
EG
T
-
QLA
Y
R
LT
G
EV
Q
D
E
D
Y
W
RNFGK
E
R
S
TF
IAP
S
--
L
TW
FG
D
-
N
A
T
-V
T
M
L
-
Y
-
SHR
D
------
Y
K
T
PF
----
--
DR
GT
I
FDLTT
KQ
P
V
N
V
DR
KI
RF
DE
P
FNI
T
DG
QS
D
--------
L
A
QL
NA
EY
H
L
N
SQ
W
T
A
R
F
D
YS
Y
S
Q
D
K
Y
SDNQAR
V
T
AY
-------------------
DA
T
T
G
--
--
-
-
---------------------------
T
L
T
R
R
VDA
T
------
QG
S
TQ
R
M
HAT
R
A
D
--
L
Q
G
NV
DI
AGF
Y
N
E
I
L
G
G
V
SYEYYDLLRT
D
MI
R
CK
K
----------
AK
D
F
N--
--
--
--
-
-
--
-
-
I
--
Y
N
P
-------------
VYGN
---
TSKCTTVSASDSDQ
T
I
KQ
E
S
Y
-
-
-
S
A
YA
Q
D
ALY
L
T
D
NWIAV
A
G
I
R
-------
Y
QYYT
Q
Y
AGKG
R
--------------
PFNVNT
-----
DS
R
D
E
Q
W
----
TP
KL
GLV
Y
K
L
T
P
S
V
S
L
F
A
N
Y
S
Q
T
F
M
P
---------
Q
S
S
IA
S
YI
G
DL
-
-
P
P
E
S
S
N
A
YE
-------
V
G
A
K
FELF
D
G-
I
T
A
D
I
A
L
F
D
I
H
K
R
NV
L
Y
T
ESV
G
D
E
T
I
AKTA
G
R
V
R
--------
S
R
GVE
V
D
L
A
---
GALT
E
N
I
N
I
IA
SY
G
Y
T
DA
K
VL
--
E
D
PD
Y
A
G
-
K
PL
PN
V
P
-----
R
H
T
G
SL
F
L
T
Y
D
I
H
N
MP
G
NNT
LT
F
G
-----
GG
G
HG
VS
RR
S
A-
---
TN
G
A
D
-
-
Y
Y
L
--
P
G
Y
F
VA
D
A
F
A
A
Y
K
M
-
K
LQYP
-V
T
LQ
L
NV
K
NLFDKTY
Y
T
S
SI
A
T
N
NL
G
NQ
I
G
D
PR
E
V
QF
T
VKM
E
F
fig|574521.7.peg.3389
Escherichia coli O127:H6 str. E2348/69 (2-713/713)
A
M
F
T
P
S
F
-----
-
SG
LK
GRA
L
FSLLF
A
APM
I
H
A
T
D
S
V
T
T
KDG
ET
IT
VTA
D
A
N
---
T
A
T
E
ATD
G
Y
Q
P
L
ST
------
S
T
A
T
L
TD
MP
ML
DIPQ
V
V
NT
VS
D
Q
V
L
E
N
Q
N
AT
TL
D
E
A
L
-
Y
NVSN
---
V
V
Q
T
N
TLG
G
T
Q
D
AFV
R
RGF
----
G
A
NR
D
G
S
I
-
M
T
N
G
L
R
T
VLPRS
F
N
--
A
A
T-
--
-
--
-
ERVEV
LK
GP
A
S
T
L
YG
IL
D
PGG
L
IN
V
V
T
KR
P
E
KTF
HGS
V
SATSSS
--
F
G
G
------
G
T
G
Q
L
--
-
--
D
I
T
GP
I
EG
T
-
QLA
Y
R
LT
G
EV
Q
D
E
D
Y
W
RNFGK
E
R
S
TF
IAP
S
--
L
TW
FG
D
-
N
A
T
-V
T
M
L
-
Y
-
SHR
D
------
Y
K
T
PF
----
--
DR
GT
I
FDLTT
KQ
P
V
N
V
DR
KI
RF
DE
P
FNI
T
DG
QS
D
--------
L
A
QL
NA
EY
H
L
N
SQ
W
T
A
R
F
D
YS
Y
S
Q
D
K
Y
SDNQAR
V
T
AY
-------------------
DA
T
T
G
--
--
-
-
---------------------------
T
L
T
R
R
VDA
T
------
QG
S
TQ
R
M
HAT
R
A
D
--
L
Q
G
NV
DI
AGF
Y
N
E
I
L
G
G
V
SYEYYDLLRT
D
MI
R
CK
K
----------
AK
D
F
N--
--
--
--
-
-
--
-
-
I
--
Y
N
P
-------------
VYGN
---
TSKCTTVSASDSDQ
T
I
KQ
E
S
Y
-
-
-
S
A
YA
Q
D
ALY
L
T
D
NWIAV
A
G
I
R
-------
Y
QYYT
Q
Y
AGKG
R
--------------
PFNVNT
-----
DS
R
D
E
Q
W
----
TP
KL
GLV
Y
K
L
T
P
S
V
S
L
F
A
N
Y
S
Q
T
F
M
P
---------
Q
S
S
IA
S
YI
G
DL
-
-
P
P
E
S
S
N
A
YE
-------
V
G
A
K
FELF
D
G-
I
T
A
D
I
A
L
F
D
I
H
K
R
NV
L
Y
T
ESV
G
D
E
T
I
AKTA
G
R
V
R
--------
S
R
GVE
V
D
L
A
---
GALT
E
N
I
N
I
IA
SY
G
Y
T
DA
K
VL
--
E
D
PD
Y
A
G
-
K
PL
PN
V
P
-----
R
H
T
G
SL
F
L
T
Y
D
I
H
N
MP
G
NNT
LT
F
G
-----
GG
G
HG
VS
RR
S
A-
---
TN
G
A
D
-
-
Y
Y
L
--
P
G
Y
F
VA
D
A
F
A
A
Y
K
M
-
K
LQYP
-V
T
LQ
L
NV
K
NLFDKTY
Y
T
S
SI
A
T
N
NL
G
NQ
I
G
D
PR
E
V
QF
T
VKM
E
F
fig|656440.3.peg.3263
Escherichia coli TA206 (2-713/713)
A
M
F
T
P
S
F
-----
-
SG
LK
GRA
L
FSLLF
A
APM
I
H
A
T
D
S
V
T
T
KDG
ET
IT
VTA
D
A
N
---
T
A
T
E
ATD
G
Y
Q
P
L
ST
------
S
T
A
T
L
TD
MP
ML
DIPQ
V
V
NT
VS
D
Q
V
L
E
N
Q
N
AT
TL
D
E
A
L
-
Y
NVSN
---
V
V
Q
T
N
TLG
G
T
Q
D
AFV
R
RGF
----
G
A
NR
D
G
S
I
-
M
T
N
G
L
R
T
VLPRS
F
N
--
A
A
T-
--
-
--
-
ERVEV
LK
GP
A
S
T
L
YG
IL
D
PGG
L
IN
V
V
T
KR
P
E
KTF
HGS
V
SATSSS
--
F
G
G
------
G
T
G
Q
L
--
-
--
D
I
T
GP
I
EG
T
-
QLA
Y
R
LT
G
EV
Q
D
E
D
Y
W
RNFGK
E
R
S
TF
IAP
S
--
L
TW
FG
D
-
N
A
T
-V
T
M
L
-
Y
-
SHR
D
------
Y
K
T
PF
----
--
DR
GT
I
FDLTT
KQ
P
V
N
V
DR
KI
RF
DE
P
FNI
T
DG
QS
D
--------
L
A
QL
NA
EY
H
L
N
SQ
W
T
A
R
F
D
YS
Y
S
Q
D
K
Y
SDNQAR
V
T
AY
-------------------
DA
T
T
G
--
--
-
-
---------------------------
T
L
T
R
R
VDA
T
------
QG
S
TQ
R
M
HAT
R
A
D
--
L
Q
G
NV
DI
AGF
Y
N
E
I
L
G
G
V
SYEYYDLLRT
D
MI
R
CK
K
----------
AK
D
F
N--
--
--
--
-
-
--
-
-
I
--
Y
N
P
-------------
VYGN
---
TSKCTTVSASDSDQ
T
I
KQ
E
S
Y
-
-
-
S
A
YA
Q
D
ALY
L
T
D
NWIAV
A
G
I
R
-------
Y
QYYT
Q
Y
AGKG
R
--------------
PFNVNT
-----
DS
R
D
E
Q
W
----
TP
KL
GLV
Y
K
L
T
P
S
V
S
L
F
A
N
Y
S
Q
T
F
M
P
---------
Q
S
S
IA
S
YI
G
DL
-
-
P
P
E
S
S
N
A
YE
-------
V
G
A
K
FELF
D
G-
I
T
A
D
I
A
L
F
D
I
H
K
R
NV
L
Y
T
ESI
G
D
E
T
I
AKTA
G
R
V
R
--------
S
R
GVE
V
D
L
A
---
GALT
E
N
I
N
I
IA
SY
G
Y
T
DA
K
VL
--
E
D
PD
Y
A
G
-
K
PL
PN
V
P
-----
R
H
T
G
SL
F
L
T
Y
D
I
H
N
MP
G
NNT
LT
F
G
-----
GG
G
HG
VS
RR
S
A-
---
TN
G
A
D
-
-
Y
Y
L
--
P
G
Y
F
VA
D
A
F
A
A
Y
K
M
-
K
LQYP
-V
T
LQ
L
NV
K
NLFDKTY
Y
T
S
SI
A
T
N
NL
G
NQ
I
G
D
PR
E
V
QF
T
VKM
E
F
fig|405955.9.peg.2866
Escherichia coli APEC O1 (2-713/713)
A
M
F
T
P
S
F
-----
-
SG
LK
GRA
L
FSLLF
A
APM
I
H
A
T
D
S
V
T
T
KDG
ET
IT
VTA
D
A
N
---
T
A
T
E
ATD
G
Y
Q
P
L
ST
------
S
T
A
T
L
TD
MP
ML
DIPQ
V
V
NT
VS
D
Q
V
L
E
N
Q
N
AT
TL
D
E
A
L
-
Y
NVSN
---
V
V
Q
T
N
TLG
G
T
Q
D
AFV
R
RGF
----
G
A
NR
D
G
S
I
-
M
T
N
G
L
R
T
VLPRS
F
N
--
A
A
T-
--
-
--
-
ERVEV
LK
GP
A
S
T
L
YG
IL
D
PGG
L
IN
V
V
T
KR
P
E
KTF
HGS
V
SATSSS
--
F
G
G
------
G
T
G
Q
L
--
-
--
D
I
T
GP
I
EG
T
-
QLA
Y
R
LT
G
EV
Q
D
E
D
Y
W
RNFGK
E
R
S
TF
IAP
S
--
L
TW
FG
D
-
N
A
T
-V
T
M
L
-
Y
-
SHR
D
------
Y
K
T
PF
----
--
DR
GT
I
FDLTT
KQ
P
V
N
V
DR
KI
RF
DE
P
FNI
T
DG
QS
D
--------
L
A
QL
NA
EY
H
L
N
SQ
W
T
A
R
F
D
YS
Y
S
Q
D
K
Y
SDNQAR
V
T
AY
-------------------
DA
T
T
G
--
--
-
-
---------------------------
T
L
T
R
R
VDA
T
------
QG
S
TQ
R
M
HAT
R
A
D
--
L
Q
G
NV
DI
AGF
Y
N
E
I
L
G
G
V
SYEYYDLLRT
D
MI
R
CK
K
----------
AK
D
F
N--
--
--
--
-
-
--
-
-
I
--
Y
N
P
-------------
VYGN
---
TSKCTTVSASDSDQ
T
I
KQ
E
N
Y
-
-
-
S
A
YA
Q
D
ALY
L
T
D
NWIAV
A
G
I
R
-------
Y
QYYT
Q
Y
AGKG
R
--------------
PFNVNT
-----
DS
R
D
E
Q
W
----
TP
KL
GLV
Y
K
L
T
P
S
V
S
L
F
A
N
Y
S
Q
T
F
M
P
---------
Q
S
S
IA
S
YI
G
DL
-
-
P
P
E
S
S
N
A
YE
-------
V
G
A
K
FELF
D
G-
I
T
A
D
I
A
L
F
D
I
H
K
R
NV
L
Y
T
ESI
G
D
E
T
I
AKTA
G
R
V
R
--------
S
R
GVE
V
D
L
A
---
GALT
E
N
I
N
I
IA
SY
G
Y
T
DA
K
VL
--
E
D
PD
Y
A
G
-
K
PL
PN
V
P
-----
R
H
T
G
SL
F
L
T
Y
D
I
H
N
MP
G
NNT
LT
F
G
-----
GG
G
HG
VS
RR
S
A-
---
TN
G
A
D
-
-
Y
Y
L
--
P
G
Y
F
VA
D
A
F
A
A
Y
K
M
-
K
LQYP
-V
T
LQ
L
NV
K
NLFDKTY
Y
T
S
SI
A
T
N
NL
G
NQ
I
G
D
PR
E
V
QF
T
VKM
E
F
fig|199310.1.peg.3689
Escherichia coli CFT073 (2-713/713)
A
M
F
T
P
S
F
-----
-
SG
LK
GRA
L
FSLLF
A
APM
I
H
A
T
D
S
V
T
T
KDG
ET
IT
VTA
D
A
N
---
T
A
T
E
ATD
G
Y
Q
P
L
ST
------
S
T
A
T
L
TD
MP
ML
DIPQ
V
V
NT
VS
D
Q
V
L
E
N
Q
N
AT
TL
D
E
A
L
-
Y
NVSN
---
V
V
Q
T
N
TLG
G
T
Q
D
AFV
R
RGF
----
G
A
NR
D
G
S
I
-
M
T
N
G
L
R
T
VLPRS
F
N
--
A
A
T-
--
-
--
-
ERVEV
LK
GP
A
S
T
L
YG
IL
D
PGG
L
IN
V
V
T
KR
P
E
KTF
HGS
V
SATSSS
--
F
G
G
------
G
T
G
Q
L
--
-
--
D
I
T
GP
I
EG
T
-
QLA
Y
R
LT
G
EV
Q
D
E
D
Y
W
RNFGK
E
R
S
TF
IAP
S
--
L
TW
FG
D
-
N
A
T
-V
T
M
L
-
Y
-
SHR
D
------
Y
K
T
PF
----
--
DR
GT
I
FDLTT
KQ
P
V
N
V
DR
KI
RF
DE
P
FNI
T
DG
QS
D
--------
L
A
QL
NA
EY
H
L
N
SQ
W
T
A
R
F
D
YS
Y
S
Q
D
K
Y
SDNQAR
V
T
AY
-------------------
DA
T
T
G
--
--
-
-
---------------------------
T
L
T
R
R
VDA
T
------
QG
S
TQ
R
M
HAT
R
A
D
--
L
Q
G
NV
DI
AGF
Y
N
E
I
L
G
G
V
SYEYYDLLRT
D
MI
R
CK
K
----------
AK
D
F
N--
--
--
--
-
-
--
-
-
I
--
Y
N
P
-------------
VYGN
---
TSKCTTVSASDSDQ
T
I
KQ
E
N
Y
-
-
-
S
A
YA
Q
D
ALY
L
T
D
NWIAV
A
G
I
R
-------
Y
QYYT
Q
Y
AGKG
R
--------------
PFNVNT
-----
DS
R
D
E
Q
W
----
TP
KL
GLV
Y
K
L
T
P
S
V
S
L
F
A
N
Y
S
Q
T
F
M
P
---------
Q
S
S
IA
S
YI
G
DL
-
-
P
P
E
S
S
N
A
YE
-------
V
G
A
K
FELF
D
G-
I
T
A
D
I
A
L
F
D
I
H
K
R
NV
L
Y
T
ESI
G
D
E
T
I
AKTA
G
R
V
R
--------
S
R
GVE
V
D
L
A
---
GALT
E
N
I
N
I
IA
SY
G
Y
T
DA
K
VL
--
E
D
PD
Y
A
G
-
K
PL
PN
V
P
-----
R
H
T
G
SL
F
L
T
Y
D
I
H
N
MP
G
NNT
LT
F
G
-----
GG
G
HG
VS
RR
S
A-
---
TN
G
A
D
-
-
Y
Y
L
--
P
G
Y
F
VA
D
A
F
A
A
Y
K
M
-
K
LQYP
-V
T
LQ
L
NV
K
NLFDKTY
Y
T
S
SI
A
T
N
NL
G
NQ
I
G
D
PR
E
V
QF
T
VKM
E
F
fig|656437.3.peg.3443
Escherichia coli TA143 (2-713/713)
A
M
F
T
P
S
F
-----
-
SG
IK
GRA
L
FSLLF
A
APM
I
H
A
T
D
T
A
T
T
KDG
ET
IT
VTA
D
A
N
---
T
A
T
E
ATD
G
Y
Q
P
L
ST
------
S
T
A
T
L
TD
MP
ML
DIPQ
V
V
NT
VS
D
Q
V
L
E
N
Q
N
AT
TL
D
E
A
L
-
Y
NVSN
---
V
V
Q
T
N
TLG
G
T
Q
D
AFV
R
RGF
----
G
A
NR
D
G
S
I
-
M
T
N
G
L
R
T
VLPRS
F
N
--
A
A
T-
--
-
--
-
ERVEV
LK
GP
A
S
T
L
YG
IL
D
PGG
L
IN
V
V
T
KR
P
E
KTF
HGS
V
SATSSS
--
F
G
G
------
G
T
G
Q
L
--
-
--
D
I
T
GP
I
EG
T
-
QLA
Y
R
LT
G
EV
Q
D
E
D
Y
W
RNFGK
E
R
S
TF
IAP
S
--
L
TW
FG
D
-
N
A
T
-V
T
M
L
-
Y
-
SHR
D
------
Y
K
T
PF
----
--
DR
GT
I
FDLTT
KQ
P
V
N
V
DR
KI
RF
DE
P
FNI
T
DG
QS
D
--------
L
A
QL
NA
EY
H
L
N
SQ
W
T
A
R
F
D
YS
Y
S
Q
D
K
Y
GDNQAR
V
T
AY
-------------------
DA
T
T
G
--
--
-
-
---------------------------
T
L
T
R
R
VDA
T
------
QG
S
TQ
R
M
HAT
R
A
D
--
L
Q
G
NV
DI
AGF
Y
N
E
I
L
G
G
V
SYEYYDLLRT
D
MI
R
CK
N
----------
AK
D
F
N--
--
--
--
-
-
--
-
-
I
--
Y
N
P
-------------
VYGN
---
TSKCTTVSASDSDQ
T
I
KQ
E
S
Y
-
-
-
S
A
YA
Q
D
ALY
L
T
D
NWIAV
A
G
I
R
-------
Y
QYYT
Q
Y
AGKG
R
--------------
PFNVNT
-----
DS
R
D
E
Q
W
----
TP
KL
GLV
Y
K
L
T
P
S
V
S
L
F
A
N
Y
S
Q
T
F
M
P
---------
Q
S
S
IA
S
YI
G
DL
-
-
P
P
E
S
S
N
A
YE
-------
V
G
A
K
FELF
D
G-
I
T
A
D
I
A
L
F
D
I
H
K
R
NV
L
Y
T
ESI
G
D
E
T
I
AKTA
G
R
V
R
--------
S
R
GVE
V
D
L
A
---
GALT
E
N
I
N
I
IA
SY
G
Y
T
DA
K
VL
--
E
D
PD
Y
A
G
-
K
PL
PN
V
P
-----
R
H
T
G
SL
F
L
T
Y
D
I
H
N
MP
G
NNT
LT
F
G
-----
GG
G
HG
VS
RR
S
A-
---
TN
G
A
D
-
-
Y
Y
L
--
P
G
Y
F
VA
D
A
F
A
A
Y
K
M
-
K
LQYP
-V
T
LQ
L
NV
K
NLFDKTY
Y
T
S
SI
A
T
N
NL
G
NQ
I
G
D
PR
E
V
QF
T
VKM
E
F
fig|656417.3.peg.254
Escherichia coli M605 (16-749/749)
IAV
V
V
A
T
A
V
-----
-
SG
MS
---
-
-----
-
---
V
Y
A
Q
A
A
V
E
P
KE-
D
T
IT
VTA
-
A
P
---
AP
Q
E
SAW
G
-
-
P
A
A
T
IAARQSAT
GTK
TDT
P
IQ
KV
PQS
IS
VV
T
A
E
E
M
A
L
H
Q
PK
SV
K
E
A
L
S
Y
TPGV
---
A
V
G
T
R
GAS
N
T
Y
D
YLI
I
RGF
-
AA
D
GQ
SQ
N
NY
L
--
-
N
G
L
K
-
MQGNF
Y
N
--
DA
VI
D
P
-
YM
L
ER
A
E
I
M
RGP
V
S
V
L
YG
KS
S
PGG
LL
NMV
S
KR
P
T
TEP
LKEV
-----
Q
--
FK
A
------
G
T
D
SL
FQ
T
GF
D
F
S
DA
L
DD
DG
VYS
Y
R
LT
G
LA
R
S
A
N
A
Q
QKGSE
E
Q
R
YAIAPA
--
F
TW
RP
D
-
D
K
T
NF
T
F
LS
Y
-
FQN
E
------
P
E
T
G
YYGW
-
LP
KE
GT
V
-----
-E
P
L
--
PN
GK
--
RL
P
TDF
N
E
G
AK
N
NTYSRNEK
M
I
GY
S
F
D
H
E
F
N
DT
FTVR
Q
N
LR
F
AQ
N
K
--
-----
-
V
SQ
-------------------
KS
V
Y
G
Y
G
MC
S
D
P
--
L
YS
SNP
---
SSSP
CA
NVPQSQW
GH
T
L
T
R
-
--
Q
Y
------
VI
D
NE
K
L
ENF
S
V
D
TQ
L
QS
KF
AT
GSV
D
H
T
L
LT
G
V
----------
D
F
MR
MR
N
------------
D
I
DSW
F
G
YA
G
S
V
A
PS
D
-
I
--
Y
NL
-------------
DRSD
-
FD
FGAH-PNPSGPYRV
L
L
KQ
K
Q
T
-
-
-
G
L
Y
VQ
D
QAQ
W
-
D
KVLVT
LG
G
R
-------
Y
DWAD
Q
-
SSFN
R
--------------
DYGNKS
-----
ER
DD
K
E
F
----
T
W
RG
G
VNY
L
F
D
N
GVT
P
Y
F
SY
S
E
SF
E
P
---------
A
S
-
QT
D
AN
G
DL
-
F
A
P
S
K
G
KQ
YE
-------
V
G
V
K
YVPE
D
RP
IV
V
T
G
A
L
Y
Q
L
T
K
T
N
NL
M
A
DP
-
N
G
S
L
F
SVEG
GE
I
R
--------
AR
GVE
L
E
AK
---
A
AL
S
A
SVN
L
VG
SYTY
T
DAE
YT
--
TDT
N
Y
K
G
-
N
TP
AQV
P
-----
KHMASLW
A
D
Y
T
F
F
DG
P
L
SG
-
LT
L
G
-----
T
G
G
R
Y
TG
--
S
S
Y
---
GD
P
A
N
-
S
F
K
V
--
GSY
T
V
VD
ALV
RY
D
LARVGMA
GS
N
VALH
VNNLFD
RE
Y
V
AS
CF
--
NT
YG
CF
W
GA
E
R
Q
V
VA
T
A
T
F
R
F
fig|525281.3.peg.1111
Escherichia coli 83972 (16-752/752)
IAV
V
V
A
T
A
V
-----
-
SG
MS
---
-
-----
-
---
V
Y
A
Q
A
A
V
E
P
KE-
D
T
IT
VTA
-
A
P
---
AP
Q
E
SAW
G
-
-
P
A
A
T
IAARQSAT
GTK
TDT
P
IQ
KV
PQS
IS
VV
T
A
E
E
M
A
L
H
Q
PK
SV
K
E
A
L
S
Y
TPGV
---
A
V
G
T
R
GAS
N
T
Y
D
YLI
I
RGF
-
AA
D
GQ
SQ
N
NY
L
--
-
N
G
L
K
-
LQGNF
Y
N
--
DA
VI
D
P
-
YM
L
ER
A
E
I
M
RGP
V
S
V
L
YG
KS
S
PGG
LL
NMV
S
KR
P
T
TEP
LKEV
-----
Q
--
FK
A
------
G
T
D
SL
FQ
T
GF
D
F
S
DA
L
DD
DG
VYS
Y
R
LT
G
LA
R
S
A
N
A
Q
QKGSE
E
Q
R
YAIAPA
--
F
TW
RP
D
-
D
K
T
NF
T
F
LS
Y
-
FQN
E
------
P
E
T
G
YYGW
-
LP
KE
GT
V
-----
-E
P
L
--
PN
GK
--
RL
P
TDF
N
E
G
AK
N
NTYSRNEK
M
I
GY
S
F
D
H
E
F
N
DT
FTVR
Q
N
LR
F
AQ
N
K
--
-----
-
V
SQ
-------------------
KS
V
Y
G
Y
G
MC
S
D
P
--
L
Y
T
K
DQEALKASP
C
LSIPQSQW
GH
T
L
T
R
-
--
Q
Y
------
VI
D
NE
K
L
ENF
S
V
D
TQ
L
QS
KF
AT
GSV
D
H
T
L
LT
G
V
----------
D
F
MR
MR
N
------------
D
I
DSW
F
G
YA
G
S
V
A
PS
D
-
I
--
Y
NL
-------------
DRSD
-
FD
FGAH-PNPSGPYRV
L
L
KQ
K
Q
T
-
-
-
G
L
Y
VQ
D
QAQ
W
-
D
KVLVT
LG
G
R
-------
Y
DWAD
Q
-
SSFN
R
--------------
DYGNKS
-----
ER
DD
K
E
F
----
T
W
RG
G
VNY
L
F
D
N
GVT
P
Y
F
SY
S
E
SF
E
P
---------
A
S
-
QT
D
AN
G
DL
-
F
A
P
S
K
G
KQ
YE
-------
V
G
V
K
YVPE
D
RP
IV
V
T
G
A
L
Y
Q
L
T
K
T
N
NL
M
A
DP
-
N
G
S
L
F
SVEG
GE
I
R
--------
AR
GVE
L
E
AK
---
A
AL
S
A
SVN
V
VG
SYTY
T
DAE
YT
--
TDTTY
K
G
-
N
TP
AQV
P
-----
KHMASLW
A
D
Y
T
F
F
DG
P
L
SG
-
LT
L
G
-----
T
G
G
R
Y
TG
--
S
S
Y
---
GD
P
A
N
-
S
F
K
V
--
GSY
T
V
VD
ALV
RY
D
LARVGMA
GS
N
VALH
VNNLFD
RE
Y
V
AS
CF
--
NT
YG
CF
W
GA
E
R
Q
V
VA
T
A
T
F
R
F
fig|655817.3.peg.178
Escherichia coli ABU 83972 (16-752/752)
IAV
V
V
A
T
A
V
-----
-
SG
MS
---
-
-----
-
---
V
Y
A
Q
A
A
V
E
P
KE-
D
T
IT
VTA
-
A
P
---
AP
Q
E
SAW
G
-
-
P
A
A
T
IAARQSAT
GTK
TDT
P
IQ
KV
PQS
IS
VV
T
A
E
E
M
A
L
H
Q
PK
SV
K
E
A
L
S
Y
TPGV
---
A
V
G
T
R
GAS
N
T
Y
D
YLI
I
RGF
-
AA
D
GQ
SQ
N
NY
L
--
-
N
G
L
K
-
LQGNF
Y
N
--
DA
VI
D
P
-
YM
L
ER
A
E
I
M
RGP
V
S
V
L
YG
KS
S
PGG
LL
NMV
S
KR
P
T
TEP
LKEV
-----
Q
--
FK
A
------
G
T
D
SL
FQ
T
GF
D
F
S
DA
L
DD
DG
VYS
Y
R
LT
G
LA
R
S
A
N
A
Q
QKGSE
E
Q
R
YAIAPA
--
F
TW
RP
D
-
D
K
T
NF
T
F
LS
Y
-
FQN
E
------
P
E
T
G
YYGW
-
LP
KE
GT
V
-----
-E
P
L
--
PN
GK
--
RL
P
TDF
N
E
G
AK
N
NTYSRNEK
M
I
GY
S
F
D
H
E
F
N
DT
FTVR
Q
N
LR
F
AQ
N
K
--
-----
-
V
SQ
-------------------
KS
V
Y
G
Y
G
MC
S
D
P
--
L
Y
T
K
DQEALKASP
C
LSIPQSQW
GH
T
L
T
R
-
--
Q
Y
------
VI
D
NE
K
L
ENF
S
V
D
TQ
L
QS
KF
AT
GSV
D
H
T
L
LT
G
V
----------
D
F
MR
MR
N
------------
D
I
DSW
F
G
YA
G
S
V
A
PS
D
-
I
--
Y
NL
-------------
DRSD
-
FD
FGAH-PNPSGPYRV
L
L
KQ
K
Q
T
-
-
-
G
L
Y
VQ
D
QAQ
W
-
D
KVLVT
LG
G
R
-------
Y
DWAD
Q
-
SSFN
R
--------------
DYGNKS
-----
ER
DD
K
E
F
----
T
W
RG
G
VNY
L
F
D
N
GVT
P
Y
F
SY
S
E
SF
E
P
---------
A
S
-
QT
D
AN
G
DL
-
F
A
P
S
K
G
KQ
YE
-------
V
G
V
K
YVPE
D
RP
IV
V
T
G
A
L
Y
Q
L
T
K
T
N
NL
M
A
DP
-
N
G
S
L
F
SVEG
GE
I
R
--------
AR
GVE
L
E
AK
---
A
AL
S
A
SVN
V
VG
SYTY
T
DAE
YT
--
TDTTY
K
G
-
N
TP
AQV
P
-----
KHMASLW
A
D
Y
T
F
F
DG
P
L
SG
-
LT
L
G
-----
T
G
G
R
Y
TG
--
S
S
Y
---
GD
P
A
N
-
S
F
K
V
--
GSY
T
V
VD
ALV
RY
D
LARVGMA
GS
N
VALH
VNNLFD
RE
Y
V
AS
CF
--
NT
YG
CF
W
GA
E
R
Q
V
VA
T
A
T
F
R
F
fig|199310.1.peg.179
Escherichia coli CFT073 (16-752/752)
IAV
V
V
A
T
A
V
-----
-
SG
MS
---
-
-----
-
---
V
Y
A
Q
A
A
V
E
P
KE-
D
T
IT
VTA
-
A
P
---
AP
Q
E
SAW
G
-
-
P
A
A
T
IAARQSAT
GTK
TDT
P
IQ
KV
PQS
IS
VV
T
A
E
E
M
A
L
H
Q
PK
SV
K
E
A
L
S
Y
TPGV
---
A
V
G
T
R
GAS
N
T
Y
D
YLI
I
RGF
-
AA
D
GQ
SQ
N
NY
L
--
-
N
G
L
K
-
LQGNF
Y
N
--
DA
VI
D
P
-
YM
L
ER
A
E
I
M
RGP
V
S
V
L
YG
KS
S
PGG
LL
NMV
S
KR
P
T
TEP
LKEV
-----
Q
--
FK
A
------
G
T
D
SL
FQ
T
GF
D
F
S
DA
L
DD
DG
VYS
Y
R
LT
G
LA
R
S
A
N
A
Q
QKGSE
E
Q
R
YAIAPA
--
F
TW
RP
D
-
D
K
T
NF
T
F
LS
Y
-
FQN
E
------
P
E
T
G
YYGW
-
LP
KE
GT
V
-----
-E
P
L
--
PN
GK
--
RL
P
TDF
N
E
G
AK
N
NTYSRNEK
M
I
GY
S
F
D
H
E
F
N
DT
FTVR
Q
N
LR
F
AQ
N
K
--
-----
-
V
SQ
-------------------
KS
V
Y
G
Y
G
MC
S
D
P
--
L
Y
T
K
DQEALKASP
C
LSIPQSQW
GH
T
L
T
R
-
--
Q
Y
------
VI
D
NE
K
L
ENF
S
V
D
TQ
L
QS
KF
AT
GSV
D
H
T
L
LT
G
V
----------
D
F
MR
MR
N
------------
D
I
DSW
F
G
YA
G
S
V
A
PS
D
-
I
--
Y
NL
-------------
DRSD
-
FD
FGAH-PNPSGPYRV
L
L
KQ
K
Q
T
-
-
-
G
L
Y
VQ
D
QAQ
W
-
D
KVLVT
LG
G
R
-------
Y
DWAD
Q
-
SSFN
R
--------------
DYGNKS
-----
ER
DD
K
E
F
----
T
W
RG
G
VNY
L
F
D
N
GVT
P
Y
F
SY
S
E
SF
E
P
---------
A
S
-
QT
D
AN
G
DL
-
F
A
P
S
K
G
KQ
YE
-------
V
G
V
K
YVPE
D
RP
IV
V
T
G
A
L
Y
Q
L
T
K
T
N
NL
M
A
DP
-
N
G
S
L
F
SVEG
GE
I
R
--------
AR
GVE
L
E
AK
---
A
AL
S
A
SVN
V
VG
SYTY
T
DAE
YT
--
TDTTY
K
G
-
N
TP
AQV
P
-----
KHMASLW
A
D
Y
T
F
F
DG
P
L
SG
-
LT
L
G
-----
T
G
G
R
Y
TG
--
S
S
Y
---
GD
P
A
N
-
S
F
K
V
--
GSY
T
V
VD
ALV
RY
D
LARVGMA
GS
N
VALH
VNNLFD
RE
Y
V
AS
CF
--
NT
YG
CF
W
GA
E
R
Q
V
VA
T
A
T
F
R
F
fig|199310.4.peg.174
Escherichia coli CFT073 (16-752/752)
IAV
V
V
A
T
A
V
-----
-
SG
MS
---
-
-----
-
---
V
Y
A
Q
A
A
V
E
P
KE-
D
T
IT
VTA
-
A
P
---
AP
Q
E
SAW
G
-
-
P
A
A
T
IAARQSAT
GTK
TDT
P
IQ
KV
PQS
IS
VV
T
A
E
E
M
A
L
H
Q
PK
SV
K
E
A
L
S
Y
TPGV
---
A
V
G
T
R
GAS
N
T
Y
D
YLI
I
RGF
-
AA
D
GQ
SQ
N
NY
L
--
-
N
G
L
K
-
LQGNF
Y
N
--
DA
VI
D
P
-
YM
L
ER
A
E
I
M
RGP
V
S
V
L
YG
KS
S
PGG
LL
NMV
S
KR
P
T
TEP
LKEV
-----
Q
--
FK
A
------
G
T
D
SL
FQ
T
GF
D
F
S
DA
L
DD
DG
VYS
Y
R
LT
G
LA
R
S
A
N
A
Q
QKGSE
E
Q
R
YAIAPA
--
F
TW
RP
D
-
D
K
T
NF
T
F
LS
Y
-
FQN
E
------
P
E
T
G
YYGW
-
LP
KE
GT
V
-----
-E
P
L
--
PN
GK
--
RL
P
TDF
N
E
G
AK
N
NTYSRNEK
M
I
GY
S
F
D
H
E
F
N
DT
FTVR
Q
N
LR
F
AQ
N
K
--
-----
-
V
SQ
-------------------
KS
V
Y
G
Y
G
MC
S
D
P
--
L
Y
T
K
DQEALKASP
C
LSIPQSQW
GH
T
L
T
R
-
--
Q
Y
------
VI
D
NE
K
L
ENF
S
V
D
TQ
L
QS
KF
AT
GSV
D
H
T
L
LT
G
V
----------
D
F
MR
MR
N
------------
D
I
DSW
F
G
YA
G
S
V
A
PS
D
-
I
--
Y
NL
-------------
DRSD
-
FD
FGAH-PNPSGPYRV
L
L
KQ
K
Q
T
-
-
-
G
L
Y
VQ
D
QAQ
W
-
D
KVLVT
LG
G
R
-------
Y
DWAD
Q
-
SSFN
R
--------------
DYGNKS
-----
ER
DD
K
E
F
----
T
W
RG
G
VNY
L
F
D
N
GVT
P
Y
F
SY
S
E
SF
E
P
---------
A
S
-
QT
D
AN
G
DL
-
F
A
P
S
K
G
KQ
YE
-------
V
G
V
K
YVPE
D
RP
IV
V
T
G
A
L
Y
Q
L
T
K
T
N
NL
M
A
DP
-
N
G
S
L
F
SVEG
GE
I
R
--------
AR
GVE
L
E
AK
---
A
AL
S
A
SVN
V
VG
SYTY
T
DAE
YT
--
TDTTY
K
G
-
N
TP
AQV
P
-----
KHMASLW
A
D
Y
T
F
F
DG
P
L
SG
-
LT
L
G
-----
T
G
G
R
Y
TG
--
S
S
Y
---
GD
P
A
N
-
S
F
K
V
--
GSY
T
V
VD
ALV
RY
D
LARVGMA
GS
N
VALH
VNNLFD
RE
Y
V
AS
CF
--
NT
YG
CF
W
GA
E
R
Q
V
VA
T
A
T
F
R
F
fig|585397.7.peg.161
Escherichia coli ED1a (16-752/752)
IAV
V
V
A
T
A
V
-----
-
SG
MS
---
-
-----
-
---
V
Y
A
Q
A
A
V
E
P
KE-
D
T
IT
VTA
-
A
P
---
AP
Q
E
SAW
G
-
-
P
A
A
T
IAARQSAT
GTK
TDT
P
IQ
KV
PQS
IS
VV
T
A
E
E
M
A
L
H
Q
PK
SV
K
E
A
L
S
Y
TPGV
---
A
V
G
T
R
GAS
N
T
Y
D
YLI
I
RGF
-
AA
D
GQ
SQ
N
NY
L
--
-
N
G
L
K
-
LQGNF
Y
N
--
DA
VI
D
P
-
YM
L
ER
A
E
I
M
RGP
V
S
V
L
YG
KS
S
PGG
LL
NMV
S
KR
P
T
TEP
LKEV
-----
Q
--
FK
A
------
G
T
D
SL
FQ
T
GF
D
F
S
DA
L
DD
DG
VYS
Y
R
LT
G
LA
R
S
A
N
A
Q
QKGSE
E
Q
R
YAIAPA
--
F
TW
RP
D
-
D
K
T
NF
T
F
LS
Y
-
FQN
E
------
P
E
T
G
YYGW
-
LP
KE
GT
V
-----
-E
P
L
--
PN
GK
--
RL
P
TDF
N
E
G
AK
N
NTYSRNEK
M
I
GY
S
F
D
H
E
F
N
DT
FTVR
Q
N
LR
F
AQ
N
K
--
-----
-
V
SQ
-------------------
KS
V
Y
G
Y
G
MC
S
D
P
--
L
Y
T
K
DQEALKASP
C
LSIPQSQW
GH
T
L
T
R
-
--
Q
Y
------
VI
D
NE
K
L
ENF
S
V
D
TQ
L
QS
KF
AT
GSV
D
H
T
L
LT
G
V
----------
D
F
MR
MR
N
------------
D
I
DSW
F
G
YA
G
S
V
A
PS
D
-
I
--
Y
NL
-------------
DRSD
-
FD
FGAH-PNPSGPYRV
L
L
KQ
K
Q
T
-
-
-
G
L
Y
VQ
D
QAQ
W
-
D
KVLVT
LG
G
R
-------
Y
DWAD
Q
-
SSFN
R
--------------
DYGNKS
-----
ER
DD
K
E
F
----
T
W
RG
G
VNY
L
F
D
N
GVT
P
Y
F
SY
S
E
SF
E
P
---------
A
S
-
QT
D
AN
G
DL
-
F
A
P
S
K
G
KQ
YE
-------
V
G
V
K
YVPE
D
RP
IV
V
T
G
A
L
Y
Q
L
T
K
T
N
NL
M
A
DP
-
N
G
S
L
F
SVEG
GE
I
R
--------
AR
GVE
L
E
AK
---
A
AL
S
A
SVN
V
VG
SYTY
T
DAE
YT
--
TDTTY
K
G
-
N
TP
AQV
P
-----
KHMASLW
A
D
Y
T
F
F
DG
P
L
SG
-
LT
L
G
-----
T
G
G
R
Y
TG
--
S
S
Y
---
GD
P
A
N
-
S
F
K
V
--
GSY
T
V
VD
ALV
RY
D
LARVGMA
GS
N
VALH
VNNLFD
RE
Y
V
AS
CF
--
NT
YG
CF
W
GA
E
R
Q
V
VA
T
A
T
F
R
F
fig|585397.9.peg.161
Escherichia coli ED1a (16-752/752)
IAV
V
V
A
T
A
V
-----
-
SG
MS
---
-
-----
-
---
V
Y
A
Q
A
A
V
E
P
KE-
D
T
IT
VTA
-
A
P
---
AP
Q
E
SAW
G
-
-
P
A
A
T
IAARQSAT
GTK
TDT
P
IQ
KV
PQS
IS
VV
T
A
E
E
M
A
L
H
Q
PK
SV
K
E
A
L
S
Y
TPGV
---
A
V
G
T
R
GAS
N
T
Y
D
YLI
I
RGF
-
AA
D
GQ
SQ
N
NY
L
--
-
N
G
L
K
-
LQGNF
Y
N
--
DA
VI
D
P
-
YM
L
ER
A
E
I
M
RGP
V
S
V
L
YG
KS
S
PGG
LL
NMV
S
KR
P
T
TEP
LKEV
-----
Q
--
FK
A
------
G
T
D
SL
FQ
T
GF
D
F
S
DA
L
DD
DG
VYS
Y
R
LT
G
LA
R
S
A
N
A
Q
QKGSE
E
Q
R
YAIAPA
--
F
TW
RP
D
-
D
K
T
NF
T
F
LS
Y
-
FQN
E
------
P
E
T
G
YYGW
-
LP
KE
GT
V
-----
-E
P
L
--
PN
GK
--
RL
P
TDF
N
E
G
AK
N
NTYSRNEK
M
I
GY
S
F
D
H
E
F
N
DT
FTVR
Q
N
LR
F
AQ
N
K
--
-----
-
V
SQ
-------------------
KS
V
Y
G
Y
G
MC
S
D
P
--
L
Y
T
K
DQEALKASP
C
LSIPQSQW
GH
T
L
T
R
-
--
Q
Y
------
VI
D
NE
K
L
ENF
S
V
D
TQ
L
QS
KF
AT
GSV
D
H
T
L
LT
G
V
----------
D
F
MR
MR
N
------------
D
I
DSW
F
G
YA
G
S
V
A
PS
D
-
I
--
Y
NL
-------------
DRSD
-
FD
FGAH-PNPSGPYRV
L
L
KQ
K
Q
T
-
-
-
G
L
Y
VQ
D
QAQ
W
-
D
KVLVT
LG
G
R
-------
Y
DWAD
Q
-
SSFN
R
--------------
DYGNKS
-----
ER
DD
K
E
F
----
T
W
RG
G
VNY
L
F
D
N
GVT
P
Y
F
SY
S
E
SF
E
P
---------
A
S
-
QT
D
AN
G
DL
-
F
A
P
S
K
G
KQ
YE
-------
V
G
V
K
YVPE
D
RP
IV
V
T
G
A
L
Y
Q
L
T
K
T
N
NL
M
A
DP
-
N
G
S
L
F
SVEG
GE
I
R
--------
AR
GVE
L
E
AK
---
A
AL
S
A
SVN
V
VG
SYTY
T
DAE
YT
--
TDTTY
K
G
-
N
TP
AQV
P
-----
KHMASLW
A
D
Y
T
F
F
DG
P
L
SG
-
LT
L
G
-----
T
G
G
R
Y
TG
--
S
S
Y
---
GD
P
A
N
-
S
F
K
V
--
GSY
T
V
VD
ALV
RY
D
LARVGMA
GS
N
VALH
VNNLFD
RE
Y
V
AS
CF
--
NT
YG
CF
W
GA
E
R
Q
V
VA
T
A
T
F
R
F
fig|749546.3.peg.3726
Escherichia coli MS 185-1 (16-752/752)
IAV
V
V
A
T
A
V
-----
-
SG
MS
---
-
-----
-
---
V
Y
A
Q
A
A
V
E
P
KE-
D
T
IT
VTA
-
A
P
---
AP
Q
E
SAW
G
-
-
P
A
A
T
IAARQSAT
GTK
TDT
P
IQ
KV
PQS
IS
VV
T
A
E
E
M
A
L
H
Q
PK
SV
K
E
A
L
S
Y
TPGV
---
A
V
G
T
R
GAS
N
T
Y
D
YLI
I
RGF
-
AA
D
GQ
SQ
N
NY
L
--
-
N
G
L
K
-
LQGNF
Y
N
--
DA
VI
D
P
-
YM
L
ER
A
E
I
M
RGP
V
S
V
L
YG
KS
S
PGG
LL
NMV
S
KR
P
T
TEP
LKEV
-----
Q
--
FK
A
------
G
T
D
SL
FQ
T
GF
D
F
S
DA
L
DD
DG
VYS
Y
R
LT
G
LA
R
S
A
N
A
Q
QKGSE
E
Q
R
YAIAPA
--
F
TW
RP
D
-
D
K
T
NF
T
F
LS
Y
-
FQN
E
------
P
E
T
G
YYGW
-
LP
KE
GT
V
-----
-E
P
L
--
PN
GK
--
RL
P
TDF
N
E
G
AK
N
NTYSRNEK
M
I
GY
S
F
D
H
E
F
N
DT
FTVR
Q
N
LR
F
AQ
N
K
--
-----
-
V
SQ
-------------------
KS
V
Y
G
Y
G
MC
S
D
P
--
L
Y
T
K
DQEALKASP
C
LSIPQSQW
GH
T
L
T
R
-
--
Q
Y
------
VI
D
NE
K
L
ENF
S
V
D
TQ
L
QS
KF
AT
GSV
D
H
T
L
LT
G
V
----------
D
F
MR
MR
N
------------
D
I
DSW
F
G
YA
G
S
V
A
PS
D
-
I
--
Y
NL
-------------
DRSD
-
FD
FGAH-PNPSGPYRV
L
L
KQ
K
Q
T
-
-
-
G
L
Y
VQ
D
QAQ
W
-
D
KVLVT
LG
G
R
-------
Y
DWAD
Q
-
SSFN
R
--------------
DYGNKS
-----
ER
DD
K
E
F
----
T
W
RG
G
VNY
L
F
D
N
GVT
P
Y
F
SY
S
E
SF
E
P
---------
A
S
-
QT
D
AN
G
DL
-
F
A
P
S
K
G
KQ
YE
-------
V
G
V
K
YVPE
D
RP
IV
V
T
G
A
L
Y
Q
L
T
K
T
N
NL
M
A
DP
-
N
G
S
L
F
SVEG
GE
I
R
--------
AR
GVE
L
E
AK
---
A
AL
S
A
SVN
V
VG
SYTY
T
DAE
YT
--
TDTTY
K
G
-
N
TP
AQV
P
-----
KHMASLW
A
D
Y
T
F
F
DG
P
L
SG
-
LT
L
G
-----
T
G
G
R
Y
TG
--
S
S
Y
---
GD
P
A
N
-
S
F
K
V
--
GSY
T
V
VD
ALV
RY
D
LARVGMA
GS
N
VALH
VNNLFD
RE
Y
V
AS
CF
--
NT
YG
CF
W
GA
E
R
Q
V
VA
T
A
T
F
R
F
fig|749528.3.peg.4662
Escherichia coli MS 45-1 (16-752/752)
IAV
V
V
A
T
A
V
-----
-
SG
MS
---
-
-----
-
---
V
Y
A
Q
A
A
V
E
P
KE-
D
T
IT
VTA
-
A
P
---
AP
Q
E
SAW
G
-
-
P
A
A
T
IAARQSAT
GTK
TDT
P
IQ
KV
PQS
IS
VV
T
A
E
E
M
A
L
H
Q
PK
SV
K
E
A
L
S
Y
TPGV
---
A
V
G
T
R
GAS
N
T
Y
D
YLI
I
RGF
-
AA
D
GQ
SQ
N
NY
L
--
-
N
G
L
K
-
LQGNF
Y
N
--
DA
VI
D
P
-
YM
L
ER
A
E
I
M
RGP
V
S
V
L
YG
KS
S
PGG
LL
NMV
S
KR
P
T
TEP
LKEV
-----
Q
--
FK
A
------
G
T
D
SL
FQ
T
GF
D
F
S
DA
L
DD
DG
VYS
Y
R
LT
G
LA
R
S
A
N
A
Q
QKGSE
E
Q
R
YAIAPA
--
F
TW
RP
D
-
D
K
T
NF
T
F
LS
Y
-
FQN
E
------
P
E
T
G
YYGW
-
LP
KE
GT
V
-----
-E
P
L
--
PN
GK
--
RL
P
TDF
N
E
G
AK
N
NTYSRNEK
M
I
GY
S
F
D
H
E
F
N
DT
FTVR
Q
N
LR
F
AQ
N
K
--
-----
-
V
SQ
-------------------
KS
V
Y
G
Y
G
MC
S
D
P
--
L
Y
T
K
DQEALKASP
C
LSIPQSQW
GH
T
L
T
R
-
--
Q
Y
------
VI
D
NE
K
L
ENF
S
V
D
TQ
L
QS
KF
AT
GSV
D
H
T
L
LT
G
V
----------
D
F
MR
MR
N
------------
D
I
DSW
F
G
YA
G
S
V
A
PS
D
-
I
--
Y
NL
-------------
DRSD
-
FD
FGAH-PNPSGPYRV
L
L
KQ
K
Q
T
-
-
-
G
L
Y
VQ
D
QAQ
W
-
D
KVLVT
LG
G
R
-------
Y
DWAD
Q
-
SSFN
R
--------------
DYGNKS
-----
ER
DD
K
E
F
----
T
W
RG
G
VNY
L
F
D
N
GVT
P
Y
F
SY
S
E
SF
E
P
---------
A
S
-
QT
D
AN
G
DL
-
F
A
P
S
K
G
KQ
YE
-------
V
G
V
K
YVPE
D
RP
IV
V
T
G
A
L
Y
Q
L
T
K
T
N
NL
M
A
DP
-
N
G
S
L
F
SVEG
GE
I
R
--------
AR
GVE
L
E
AK
---
A
AL
S
A
SVN
V
VG
SYTY
T
DAE
YT
--
TDTTY
K
G
-
N
TP
AQV
P
-----
KHMASLW
A
D
Y
T
F
F
DG
P
L
SG
-
LT
L
G
-----
T
G
G
R
Y
TG
--
S
S
Y
---
GD
P
A
N
-
S
F
K
V
--
GSY
T
V
VD
ALV
RY
D
LARVGMA
GS
N
VALH
VNNLFD
RE
Y
V
AS
CF
--
NT
YG
CF
W
GA
E
R
Q
V
VA
T
A
T
F
R
F
fig|753642.3.peg.3470
Escherichia coli NC101 (16-752/752)
IAV
V
V
A
T
A
V
-----
-
SG
MS
---
-
-----
-
---
V
Y
A
Q
A
A
V
E
P
KE-
D
T
IT
VTA
-
A
P
---
AP
Q
E
SAW
G
-
-
P
A
A
T
IAARQSAT
GTK
TDT
P
IQ
KV
PQS
IS
VV
T
A
E
E
M
A
L
H
Q
PK
SV
K
E
A
L
S
Y
TPGV
---
A
V
G
T
R
GAS
N
T
Y
D
YLI
I
RGF
-
AA
D
GQ
SQ
N
NY
L
--
-
N
G
L
K
-
LQGNF
Y
N
--
DA
VI
D
P
-
YM
L
ER
A
E
I
M
RGP
V
S
V
L
YG
KS
S
PGG
LL
NMV
S
KR
P
T
TEP
LKEV
-----
Q
--
FK
A
------
G
T
D
SL
FQ
T
GF
D
F
S
DA
L
DD
DG
VYS
Y
R
LT
G
LA
R
S
A
N
A
Q
QKGSE
E
Q
R
YAIAPA
--
F
TW
RP
D
-
D
K
T
NF
T
F
LS
Y
-
FQN
E
------
P
E
T
G
YYGW
-
LP
KE
GT
V
-----
-E
P
L
--
PN
GK
--
RL
P
TDF
N
E
G
AK
N
NTYSRNEK
M
I
GY
S
F
D
H
E
F
N
DT
FTVR
Q
N
LR
F
AQ
N
K
--
-----
-
V
SQ
-------------------
KS
V
Y
G
Y
G
MC
S
D
P
--
L
Y
T
K
DQEALKASP
C
LSIPQSQW
GH
T
L
T
R
-
--
Q
Y
------
VI
D
NE
K
L
ENF
S
V
D
TQ
L
QS
KF
AT
GSV
D
H
T
L
LT
G
V
----------
D
F
MR
MR
N
------------
D
I
DSW
F
G
YA
G
S
V
A
PS
D
-
I
--
Y
NL
-------------
DRSD
-
FD
FGAH-PNPSGPYRV
L
L
KQ
K
Q
T
-
-
-
G
L
Y
VQ
D
QAQ
W
-
D
KVLVT
LG
G
R
-------
Y
DWAD
Q
-
SSFN
R
--------------
DYGNKS
-----
ER
DD
K
E
F
----
T
W
RG
G
VNY
L
F
D
N
GVT
P
Y
F
SY
S
E
SF
E
P
---------
A
S
-
QT
D
AN
G
DL
-
F
A
P
S
K
G
KQ
YE
-------
V
G
V
K
YVPE
D
RP
IV
V
T
G
A
L
Y
Q
L
T
K
T
N
NL
M
A
DP
-
N
G
S
L
F
SVEG
GE
I
R
--------
AR
GVE
L
E
AK
---
A
AL
S
A
SVN
V
VG
SYTY
T
DAE
YT
--
TDTTY
K
G
-
N
TP
AQV
P
-----
KHMASLW
A
D
Y
T
F
F
DG
P
L
SG
-
LT
L
G
-----
T
G
G
R
Y
TG
--
S
S
Y
---
GD
P
A
N
-
S
F
K
V
--
GSY
T
V
VD
ALV
RY
D
LARVGMA
GS
N
VALH
VNNLFD
RE
Y
V
AS
CF
--
NT
YG
CF
W
GA
E
R
Q
V
VA
T
A
T
F
R
F
fig|656440.3.peg.5242
Escherichia coli TA206 (16-752/752)
IAV
V
V
A
T
A
V
-----
-
SG
MS
---
-
-----
-
---
V
Y
A
Q
A
A
V
E
P
KE-
D
T
IT
VTA
-
A
P
---
AP
Q
E
SAW
G
-
-
P
A
A
T
IAARQSAT
GTK
TDT
P
IQ
KV
PQS
IS
VV
T
A
E
E
M
A
L
H
Q
PK
SV
K
E
A
L
S
Y
TPGV
---
A
V
G
T
R
GAS
N
T
Y
D
YLI
I
RGF
-
AA
D
GQ
SQ
N
NY
L
--
-
N
G
L
K
-
MQGNF
Y
N
--
DA
VI
D
P
-
YM
L
ER
A
E
I
M
RGP
V
S
V
L
YG
KS
S
PGG
LL
NMV
S
KR
P
T
TEP
LKEV
-----
Q
--
FK
A
------
G
T
D
SL
FQ
T
GF
D
F
S
DA
L
DD
DG
VYS
Y
R
LT
G
LA
R
S
A
N
A
Q
QKGSE
E
Q
R
YAIAPA
--
F
TW
RP
D
-
D
K
T
NF
T
F
LS
Y
-
FQN
E
------
P
E
T
G
YYGW
-
LP
KE
GT
V
-----
-E
P
L
--
PN
GK
--
RL
P
TDF
N
E
G
AK
N
NTYSRNEK
M
I
GY
S
F
D
H
E
F
N
DT
FTVR
Q
N
LR
F
AQ
N
K
--
-----
-
V
SQ
-------------------
KS
V
Y
G
Y
G
MC
S
D
P
--
L
Y
T
K
DQEALKASP
C
LSIPQSQW
GH
T
L
T
R
-
--
Q
Y
------
VI
D
NE
K
L
ENF
S
V
D
TQ
L
QS
KF
AT
GSV
G
H
T
L
LT
G
V
----------
D
F
MR
MR
N
------------
D
I
DSW
F
G
YA
G
S
V
A
PS
D
-
I
--
Y
NL
-------------
DRSD
-
FD
FGAH-PNPSGPYRV
L
L
KQ
K
Q
T
-
-
-
G
L
Y
VQ
D
QAQ
W
-
D
KVLVT
LG
G
R
-------
Y
DWAD
Q
-
SSFN
R
--------------
DYGNKS
-----
ER
DD
K
E
F
----
T
W
RG
G
VNY
L
F
D
N
GVT
P
Y
F
SY
S
E
SF
E
P
---------
A
S
-
QT
D
AN
G
DL
-
F
A
P
S
K
G
KQ
YE
-------
V
G
V
K
YVPE
D
RP
IV
V
T
G
A
L
Y
Q
L
T
K
T
N
NL
M
A
DP
-
N
G
S
L
F
SVEG
GE
I
R
--------
AR
GVE
L
E
AK
---
A
AL
S
A
SVN
V
VG
SYTY
T
DAE
YT
--
TDTTY
K
G
-
N
TP
AQV
P
-----
KHMASLW
A
D
Y
T
F
F
DG
P
L
SG
-
LT
L
G
-----
T
G
G
R
Y
TG
--
S
S
Y
---
GD
P
A
N
-
S
F
K
V
--
GSY
T
V
VD
ALV
RY
D
LARVGMA
GS
N
VALH
VNNLFD
RE
Y
V
AS
CF
--
NT
YG
CF
W
GA
E
R
Q
V
VA
T
A
T
F
R
F
fig|216592.1.peg.4255
Escherichia coli 042 (16-749/749)
IAV
V
V
A
T
A
V
-----
-
SG
MS
---
-
-----
-
---
V
Y
A
Q
A
A
V
E
P
KE-
D
T
IT
VTA
-
A
P
---
AP
Q
E
SAW
G
-
-
P
A
A
T
IAARQSAT
GTK
TDT
P
IQ
KV
PQS
IS
VV
T
A
E
E
M
A
L
H
Q
PK
SV
K
E
A
L
S
Y
TPGV
---
A
V
G
T
R
GAS
N
T
Y
D
YLI
I
RGF
-
AA
D
GQ
SQ
N
NY
L
--
-
N
G
L
K
-
MQGNF
Y
N
--
DA
VI
D
P
-
YM
L
ER
A
E
I
M
RGP
V
S
V
L
YG
KS
S
PGG
LL
NMV
S
KR
P
T
TEP
LKEV
-----
Q
--
FK
A
------
G
T
D
SL
FQ
T
GF
D
F
S
DA
L
DD
DG
VYS
Y
R
LT
G
LA
R
S
A
N
A
Q
QKGAE
E
Q
R
YAIAPA
--
F
TW
RP
D
-
D
K
T
NF
T
F
LS
Y
-
FQN
E
------
P
E
T
G
YYGW
-
LP
KE
GT
V
-----
-E
P
L
--
PN
GK
--
RL
P
TDF
N
E
G
AK
N
NTYSRNEK
M
I
GY
S
F
D
H
E
F
N
DT
FTVR
Q
N
LR
F
AQ
N
K
--
-----
-
V
SQ
-------------------
KS
V
Y
G
Y
G
MC
S
D
P
--
L
YS
SNP
---
SSSP
CA
NVPQSQW
GH
T
L
T
R
-
--
Q
Y
------
VI
D
NE
K
L
ENF
S
V
D
TQ
L
QS
KF
AT
GSV
D
H
T
L
LT
G
V
----------
D
F
MR
MR
N
------------
D
I
DSW
F
G
YA
G
S
V
A
PS
D
-
I
--
Y
NL
-------------
DRSD
-
FD
FGAH-PNPSGPYRV
L
L
KQ
K
Q
T
-
-
-
G
L
Y
VQ
D
QAQ
W
-
D
KVLVT
LG
G
R
-------
Y
DWAD
Q
-
SSFN
R
--------------
DYGNKS
-----
DR
DD
K
QF
----
T
W
RG
G
VNY
L
F
D
N
GVT
P
Y
F
SY
S
E
SF
E
P
---------
A
S
-
QT
D
AN
G
DL
-
F
A
P
S
K
G
KQ
YE
-------
V
G
V
K
YVPE
D
RP
IV
V
T
G
A
L
Y
Q
L
T
K
T
N
NL
M
A
DP
-
N
G
S
L
F
SVEG
GE
I
R
--------
AR
GVE
L
E
AK
---
A
AL
S
A
SVN
L
VG
SYTY
T
DAE
YT
--
TDTTY
K
G
-
N
TP
AQV
P
-----
KHMASLW
A
D
Y
T
F
F
DG
P
L
SG
-
LT
L
G
-----
T
G
G
R
Y
TG
--
S
S
Y
---
GD
P
A
N
-
S
F
K
V
--
GSY
T
V
VD
ALV
RY
D
LARVGMA
GS
N
VALH
VNNLFD
RE
Y
V
AS
CF
--
NT
YG
CF
W
GA
E
R
Q
V
VA
T
A
T
F
R
F
fig|585057.4.peg.168
Escherichia coli IAI39 (16-749/749)
IAV
V
V
A
T
A
V
-----
-
SG
MS
---
-
-----
-
---
V
Y
A
Q
A
A
V
E
P
KE-
D
T
IT
VTA
-
A
P
---
AP
Q
E
SAW
G
-
-
P
A
A
T
IAARQSAT
GTK
TDT
P
IQ
KV
PQS
IS
VV
T
A
E
E
M
A
L
H
Q
PK
SV
K
E
A
L
S
Y
TPGV
---
A
V
G
T
R
GAS
N
T
Y
D
YLI
I
RGF
-
AA
D
GQ
SQ
N
NY
L
--
-
N
G
L
K
-
MQGNF
Y
N
--
DA
VI
D
P
-
YM
L
ER
A
E
I
M
RGP
V
S
V
L
YG
KS
S
PGG
LL
NMV
S
KR
P
T
TEP
LKEV
-----
Q
--
FK
A
------
G
T
D
SL
FQ
T
GF
D
F
S
DA
L
DD
DG
VYS
Y
R
LT
G
LA
R
S
A
N
A
Q
QKGAE
E
Q
R
YAIAPA
--
F
TW
RP
D
-
D
K
T
NF
T
F
LS
Y
-
FQN
E
------
P
E
T
G
YYGW
-
LP
KE
GT
V
-----
-E
P
L
--
PN
GK
--
RL
P
TDF
N
E
G
AK
N
NTYSRNEK
M
I
GY
S
F
D
H
E
F
N
DT
FTVR
Q
N
LR
F
AQ
N
K
--
-----
-
V
SQ
-------------------
KS
V
Y
G
Y
G
MC
S
D
P
--
L
YS
SNP
---
SSSP
CA
NVPQSQW
GH
T
L
T
R
-
--
Q
Y
------
VI
D
NE
K
L
ENF
S
V
D
TQ
L
QS
KF
AT
GSV
D
H
T
L
LT
G
V
----------
D
F
MR
MR
N
------------
D
I
DSW
F
G
YA
G
S
V
A
PS
D
-
I
--
Y
NL
-------------
DRSD
-
FD
FGAH-PNPSGPYRV
L
L
KQ
K
Q
T
-
-
-
G
L
Y
VQ
D
QAQ
W
-
D
KVLVT
LG
G
R
-------
Y
DWAD
Q
-
SSFN
R
--------------
DYGNKS
-----
DR
DD
K
QF
----
T
W
RG
G
VNY
L
F
D
N
GVT
P
Y
F
SY
S
E
SF
E
P
---------
A
S
-
QT
D
AN
G
DL
-
F
A
P
S
K
G
KQ
YE
-------
V
G
V
K
YVPE
D
RP
IV
V
T
G
A
L
Y
Q
L
T
K
T
N
NL
M
A
DP
-
N
G
S
L
F
SVEG
GE
I
R
--------
AR
GVE
L
E
AK
---
A
AL
S
A
SVN
L
VG
SYTY
T
DAE
YT
--
TDTTY
K
G
-
N
TP
AQV
P
-----
KHMASLW
A
D
Y
T
F
F
DG
P
L
SG
-
LT
L
G
-----
T
G
G
R
Y
TG
--
S
S
Y
---
GD
P
A
N
-
S
F
K
V
--
GSY
T
V
VD
ALV
RY
D
LARVGMA
GS
N
VALH
VNNLFD
RE
Y
V
AS
CF
--
NT
YG
CF
W
GA
E
R
Q
V
VA
T
A
T
F
R
F
fig|331112.3.peg.150
Escherichia coli HS (16-729/729)
IAV
V
V
A
T
A
V
-----
-
SG
MS
---
-
-----
-
---
V
Y
A
Q
A
A
V
E
P
KE-
D
T
IT
VTA
-
A
P
---
AP
Q
E
SAW
G
-
-
P
A
A
T
IAA
KH
SAT
A
TK
TDT
P
IE
K
T
PQS
IS
VV
T
N
E
E
M
Q
M
H
Q
FQ
SV
K
E
A
L
G
Y
TPGV
---
T
V
S
S
R
GAS
N
T
Y
D
FVI
I
RGF
-
SSV
G
L
NQ
N
NY
L
--
-
DG
L
K
-
LQGNF
Y
N
--
DA
VI
D
P
-
YM
L
ERVE
LM
RGP
T
S
V
L
YG
KS
NPGG
I
I
S
MV
S
KR
P
T
TEP
LKE
I
-----
Q
--
FK
M
------
G
T
D
N
L
FQ
T
GF
D
F
S
DA
L
DD
N
G
EFS
Y
R
LT
G
LA
R
S
T
N
E
Q
QKNSE
S
Q
R
Y
T
IAP
S
--
FS
W
RP
D
-
D
K
T
NF
T
F
LS
Y
-
FQN
E
------
P
E
T
G
YYGW
-
LP
KE
GT
V
-----
-E
P
L
--
PN
GK
--
RL
P
TDF
N
E
G
AS
N
NTYSRN
Q
K
M
V
GY
S
F
E
H
G
F
N
DT
FTVR
Q
N
LR
F
SE
M
K
--
-----
-
T
SQ
-------------------
KS
V
Y
GTG
IA
N
D
-------------------------
GH
T
L
N
R
-
--
GT
------
VV
D
NE
R
L
QNF
S
V
D
TQ
L
E
S
KF
AT
GEV
E
H
T
L
LT
G
V
----------
D
F
MR
MR
N
------------
D
I
NAS
F
G
--
-
S
A
P
SI
D
-
L
--
Y
N
K
-------------
YHPE
Y
F
A
FG-----NAEPYQ-
M
N
E
SK
Q
T
-
-
-
G
I
Y
VQ
D
QAE
W
-
N
KWVFT
LG
G
R
-------
Y
DWSK
Q
-
ATTV
R
--------------
ENSYTP
TEGYI
ER
N
D
H
QF
----
T
W
RG
G
VNY
L
F
D
N
G
I
S
P
Y
F
SY
S
Q
SF
E
P
---------
S
AF
DL
W
SN
P
RV
SY
K
P
S
K
G
E
Q
YE
-------
A
G
V
K
YVPN
D
MP
V
V
V
T
G
A
V
Y
Q
L
T
K
T
N
NL
T
A
DP
-
T
NP
L
A
QVPA
GE
I
R
--------
AR
GVE
L
E
AK
---
A
AL
N
A
N
I
N
L
TA
SYTY
T
DAE
YT
--
K
DT
NL
K
G
-
K
TP
E
QV
P
-----
E
HMASLW
G
D
Y
T
F
N
E
G
P
L
SG
-
LT
L
G
-----
T
G
G
R
F
IG
--
S
S
Y
---
GD
P
A
N
-
TF
K
V
--
GS
A
A
V
M
D
A
V
V
K
Y
D
LAR
F
GMA
GS
SL
A
V
NVNNL
L
D
RE
Y
V
AS
CF
--
Q
T
YG
CF
W
GA
E
R
Q
V
VA
T
A
T
F
R
F
fig|749533.3.peg.3179
Escherichia coli MS 84-1 (16-729/729)
IAV
V
V
A
T
A
V
-----
-
SG
MS
---
-
-----
-
---
V
Y
A
Q
A
A
V
E
P
KE-
D
T
IT
VTA
-
A
P
---
AP
Q
E
SAW
G
-
-
P
A
A
T
IAA
KH
SAT
A
TK
TDT
P
IE
K
T
PQS
IS
VV
T
N
E
E
M
Q
M
H
Q
FQ
SV
K
E
A
L
G
Y
TPGV
---
T
V
S
S
R
GAS
N
T
Y
D
FVI
I
RGF
-
SSV
G
L
NQ
N
NY
L
--
-
DG
L
K
-
LQGNF
Y
N
--
DA
VI
D
P
-
YM
L
ERVE
LM
RGP
T
S
V
L
YG
KS
NPGG
I
I
S
MV
S
KR
P
T
TEP
LKE
I
-----
Q
--
FK
M
------
G
T
D
N
L
FQ
T
GF
D
F
S
DA
L
DD
N
G
EFS
Y
R
LT
G
LA
R
S
T
N
E
Q
QKNSE
S
Q
R
Y
T
IAP
S
--
FS
W
RP
D
-
D
K
T
NF
T
F
LS
Y
-
FQN
E
------
P
E
T
G
YYGW
-
LP
KE
GT
V
-----
-E
P
L
--
PN
GK
--
RL
P
TDF
N
E
G
AS
N
NTYSRN
Q
K
M
V
GY
S
F
E
H
G
F
N
DT
FTVR
Q
N
LR
F
SE
M
K
--
-----
-
T
SQ
-------------------
KS
V
Y
GTG
IA
N
D
-------------------------
GH
T
L
N
R
-
--
GT
------
VV
D
NE
R
L
QNF
S
V
D
TQ
L
E
S
KF
AT
GEV
E
H
T
L
LT
G
V
----------
D
F
MR
MR
N
------------
D
I
NAS
F
G
--
-
S
A
P
SI
D
-
L
--
Y
N
K
-------------
YHPE
Y
F
A
FG-----NAEPYQ-
M
N
E
SK
Q
T
-
-
-
G
I
Y
VQ
D
QAE
W
-
N
KWVFT
LG
G
R
-------
Y
DWSK
Q
-
ATTV
R
--------------
ENSYTP
TEGYI
ER
N
D
H
QF
----
T
W
RG
G
VNY
L
F
D
N
G
I
S
P
Y
F
SY
S
Q
SF
E
P
---------
S
AF
DL
W
SN
P
RV
SY
K
P
S
K
G
E
Q
YE
-------
A
G
V
K
YVPN
D
MP
V
V
V
T
G
A
V
Y
Q
L
T
K
T
N
NL
T
A
DP
-
T
NP
L
A
QVPA
GE
I
R
--------
AR
GVE
L
E
AK
---
A
AL
N
A
N
I
N
L
TA
SYTY
T
DAE
YT
--
K
DT
NL
K
G
-
K
TP
E
QV
P
-----
E
HMASLW
G
D
Y
T
F
N
E
G
P
L
SG
-
LT
L
G
-----
T
G
G
R
F
IG
--
S
S
Y
---
GD
P
A
N
-
TF
K
V
--
GS
A
A
V
M
D
A
V
V
K
Y
D
LAR
F
GMA
GS
SL
A
V
NVNNL
L
D
RE
Y
V
AS
CF
--
Q
T
YG
CF
W
GA
E
R
Q
V
VA
T
A
T
F
R
F
fig|656419.3.peg.319
Escherichia coli M718 (16-731/731)
IAV
V
V
A
T
A
V
-----
-
SG
MS
---
-
-----
-
---
V
Y
A
Q
A
A
V
E
P
KE-
D
T
IT
VTA
-
A
P
---
AP
Q
E
SAW
G
-
-
P
A
A
T
IAA
KH
SAT
A
TK
TDT
P
IE
K
T
PQS
IS
VV
T
R
E
E
M
D
I
K
Q
PA
T
V
K
E
A
L
D
Y
TP
S
V
---
-
F
S
T
R
G
S
S
T
T
Y
D
VVS
I
RGF
TTPSTV
NT
N
Q
Y
L
--
-
DG
L
K
-
LQGDN
YS
--
E
A
SI
D
P
-
Y
F
L
ERVE
LL
RGP
V
S
V
L
YG
KS
H
PGG
V
VS
MV
S
KR
P
S
TDP
I
KE
I
-----
Q
--
FK
M
------
G
T
D
N
L
WQ
T
GF
D
F
S
DA
I
DD
DG
VWS
Y
R
LT
G
LG
R
S
Q
D
A
Q
QKYAK
T
T
R
YA
V
AP
S
--
FS
W
RP
D
-
D
K
T
DL
T
F
LS
N
-
FQS
D
------
P
D
A
G
YYGW
-
LP
RQ
GT
V
-----
-V
P
Y
QDA
N
GS
WH
KL
P
TDF
N
E
G
EK
DN
KM
SR
RQQ
L
I
GY
S
F
A
H
E
F
N
DT
FTVR
Q
N
LR
YT
R
I
H
--
-----
-
T
L
Y
-------------------
DA
V
Y
G
NS
YI
A
P
A
--------------------------
Q
I
S
R
-
--
A
Y
------
VR
S
DE
D
L
NSF
T
V
D
TQ
L
QS
NF
AT
GAV
A
H
T
L
LT
G
V
----------
D
Y
L
R
MR
N
------------
D
I
DAN
YG
TA
D
P
I
S
MQ
D
P
Q
--
Y
GN
-------------
ANIN
-
IN
F---------PYAV
I
N
R
Q
E
Q
T
-
-
-
G
L
Y
I
Q
D
QSE
W
-
N
KWVLT
LG
G
R
-------
Y
DFAK
T
-
STYT
R
--------------
STSSLD
-----
EI
N
D
Q
QF
----
T
W
RG
G
I
NY
L
F
D
N
G
I
S
P
Y
F
SY
S
E
SF
E
P
---------
V
S
-
GA
T
KE
G
KP
-
F
D
P
S
R
G
KQ
YE
-------
A
G
V
K
YVPK
D
TP
V
T
V
T
A
SV
F
Q
L
T
K
D
K
NL
T
A
DP
-
S
NI
L
F
SVQG
GE
I
R
--------
S
R
G
F
E
I
E
AK
---
A
AL
N
A
N
I
N
V
TA
A
Y
S
Y
T
DAE
YT
--
K
DT
L
Y
K
G
-
K
RP
A
E
V
P
-----
R
N
MASLW
A
D
Y
T
F
R
ETA
L
SG
-
L
S
F
G
-----
A
G
A
R
Y
FG
D
T
S
S
F
YT
T
GE
K
A
N
Q
TF
N
V
--
G
G
Y
T
LVD
A
MI
K
Y
D
LAR
F
GM
P
GS
S
V
GV
NVNNLFD
RE
Y
V
S
S
CY
--
RD
Y
A
CY
W
GA
E
R
Q
V
VA
T
A
T
F
R
F
fig|656379.3.peg.393
Escherichia coli FVEC1302 (16-752/752)
IAV
V
V
A
T
A
V
-----
-
SG
MS
---
-
-----
-
---
V
Y
A
Q
A
A
V
E
P
KE-
D
T
IT
VTA
-
A
P
---
AP
Q
E
SAW
G
-
-
P
A
A
T
IAARQSAT
GTK
TDT
P
IQ
KV
PQS
IS
VV
T
A
E
E
M
A
L
H
Q
PK
SV
K
E
A
L
S
Y
TPGV
---
A
V
G
T
R
GAS
N
T
Y
D
YLI
I
RGF
-
AA
D
GQ
SQ
N
NY
L
--
-
N
G
L
K
-
MQGNF
Y
N
--
DA
VI
D
P
-
YM
L
ER
A
E
I
M
RGP
V
S
V
L
YG
KS
S
PGG
LL
NMV
S
KR
P
T
TEP
LKE
I
-----
Q
--
FK
A
------
G
T
D
SL
FQ
T
GF
D
F
S
DA
L
DD
DG
VYS
Y
R
LT
G
IA
R
S
A
N
A
Q
QKGAE
E
Q
R
YAIAPA
--
F
TW
RP
D
-
D
K
T
NF
T
F
LS
Y
-
FQN
E
------
P
E
T
G
YYGW
-
LP
KE
GT
V
-----
-E
P
L
--
PN
GK
--
RL
P
TDF
N
E
G
AK
N
NTYSRNEK
M
V
GY
S
F
D
H
E
F
N
DT
FTVR
Q
N
LR
F
AQ
N
K
--
-----
-
V
SQ
-------------------
KS
V
Y
G
Y
G
MC
S
D
P
--
L
Y
T
K
DDDALKASP
C
LSIPQSEWN
H
T
L
T
R
-
--
Q
Y
------
VI
D
NE
K
L
ENF
S
V
D
TQ
L
QS
KF
AT
GSV
E
H
T
L
LT
G
V
----------
D
F
MR
MR
N
------------
D
I
DSW
F
G
YA
G
S
V
A
PS
D
-
I
--
Y
NL
-------------
DRSD
-
FD
FGAH-PDPSGPYRV
L
L
KQ
K
Q
T
-
-
-
G
L
Y
VQ
D
QAQ
W
-
D
KVLVT
LG
G
R
-------
Y
DWAE
Q
-
SSFN
R
--------------
DYGNKS
-----
DR
DD
K
QF
----
T
W
RG
G
VNY
L
F
D
N
GVT
P
Y
F
SY
S
E
SF
E
P
---------
A
S
-
LT
D
AN
G
DL
-
F
A
P
S
K
G
KQ
YE
-------
V
G
V
K
YVPE
D
RP
IV
L
T
G
A
L
Y
Q
L
T
K
T
N
NL
M
A
DP
-
N
NP
N
F
SIEG
GE
I
R
--------
AR
GVE
L
E
AK
---
A
AL
S
A
SVN
V
VG
SYTY
T
DAE
YT
--
TDTTY
K
G
-
N
TP
AQV
P
-----
KHMASLW
A
D
Y
T
F
F
DG
P
L
SG
-
LT
L
G
-----
T
G
G
R
Y
TG
--
S
S
Y
---
GD
P
A
N
-
S
F
K
V
--
GSY
T
V
VD
ALV
RY
D
LARVGMA
GS
N
VALH
VNNLFD
RE
Y
V
AS
CF
--
NT
YG
CF
W
GA
E
R
Q
V
VA
T
A
T
F
R
F
fig|656380.3.peg.330
Escherichia coli FVEC1412 (16-752/752)
IAV
V
V
A
T
A
V
-----
-
SG
MS
---
-
-----
-
---
V
Y
A
Q
A
A
V
E
P
KE-
D
T
IT
VTA
-
A
P
---
AP
Q
E
SAW
G
-
-
P
A
A
T
IAARQSAT
GTK
TDT
P
IQ
KV
PQS
IS
VV
T
A
E
E
M
A
L
H
Q
PK
SV
K
E
A
L
S
Y
TPGV
---
A
V
G
T
R
GAS
N
T
Y
D
YLI
I
RGF
-
AA
D
GQ
SQ
N
NY
L
--
-
N
G
L
K
-
MQGNF
Y
N
--
DA
VI
D
P
-
YM
L
ER
A
E
I
M
RGP
V
S
V
L
YG
KS
S
PGG
LL
NMV
S
KR
P
T
TEP
LKE
I
-----
Q
--
FK
A
------
G
T
D
SL
FQ
T
GF
D
F
S
DA
L
DD
DG
VYS
Y
R
LT
G
IA
R
S
A
N
A
Q
QKGAE
E
Q
R
YAIAPA
--
F
TW
RP
D
-
D
K
T
NF
T
F
LS
Y
-
FQN
E
------
P
E
T
G
YYGW
-
LP
KE
GT
V
-----
-E
P
L
--
PN
GK
--
RL
P
TDF
N
E
G
AK
N
NTYSRNEK
M
V
GY
S
F
D
H
E
F
N
DT
FTVR
Q
N
LR
F
AQ
N
K
--
-----
-
V
SQ
-------------------
KS
V
Y
G
Y
G
MC
S
D
P
--
L
Y
T
K
DDDALKASP
C
LSIPQSEWN
H
T
L
T
R
-
--
Q
Y
------
VI
D
NE
K
L
ENF
S
V
D
TQ
L
QS
KF
AT
GSV
E
H
T
L
LT
G
V
----------
D
F
MR
MR
N
------------
D
I
DSW
F
G
YA
G
S
V
A
PS
D
-
I
--
Y
NL
-------------
DRSD
-
FD
FGAH-PDPSGPYRV
L
L
KQ
K
Q
T
-
-
-
G
L
Y
VQ
D
QAQ
W
-
D
KVLVT
LG
G
R
-------
Y
DWAE
Q
-
SSFN
R
--------------
DYGNKS
-----
DR
DD
K
QF
----
T
W
RG
G
VNY
L
F
D
N
GVT
P
Y
F
SY
S
E
SF
E
P
---------
A
S
-
LT
D
AN
G
DL
-
F
A
P
S
K
G
KQ
YE
-------
V
G
V
K
YVPE
D
RP
IV
L
T
G
A
L
Y
Q
L
T
K
T
N
NL
M
A
DP
-
N
NP
N
F
SIEG
GE
I
R
--------
AR
GVE
L
E
AK
---
A
AL
S
A
SVN
V
VG
SYTY
T
DAE
YT
--
TDTTY
K
G
-
N
TP
AQV
P
-----
KHMASLW
A
D
Y
T
F
F
DG
P
L
SG
-
LT
L
G
-----
T
G
G
R
Y
TG
--
S
S
Y
---
GD
P
A
N
-
S
F
K
V
--
GSY
T
V
VD
ALV
RY
D
LARVGMA
GS
N
VALH
VNNLFD
RE
Y
V
AS
CF
--
NT
YG
CF
W
GA
E
R
Q
V
VA
T
A
T
F
R
F
fig|749549.3.peg.4666
Escherichia coli MS 198-1 (16-752/752)
IAV
V
V
A
T
A
V
-----
-
SG
MS
---
-
-----
-
---
V
Y
A
Q
A
A
V
E
P
KE-
D
T
IT
VTA
-
A
P
---
AP
Q
E
SAW
G
-
-
P
A
A
T
IAARQSAT
GTK
TDT
P
IQ
KV
PQS
IS
VV
T
A
E
E
M
A
L
H
Q
PK
SV
K
E
A
L
S
Y
TPGV
---
A
V
G
T
R
GAS
N
T
Y
D
YLI
I
RGF
-
AA
D
GQ
SQ
N
NY
L
--
-
N
G
L
K
-
MQGNF
Y
N
--
DA
VI
D
P
-
YM
L
ER
A
E
I
M
RGP
V
S
V
L
YG
KS
S
PGG
LL
NMV
S
KR
P
T
TEP
LKE
I
-----
Q
--
FK
A
------
G
T
D
SL
FQ
T
GF
D
F
S
DA
L
DD
DG
VYS
Y
R
LT
G
IA
R
S
A
N
A
Q
QKGAE
E
Q
R
YAIAPA
--
F
TW
RP
D
-
D
K
T
NF
T
F
LS
Y
-
FQN
E
------
P
E
T
G
YYGW
-
LP
KE
GT
V
-----
-E
P
L
--
PN
GK
--
RL
P
TDF
N
E
G
AK
N
NTYSRNEK
M
V
GY
S
F
D
H
E
F
N
DT
FTVR
Q
N
LR
F
AQ
N
K
--
-----
-
V
SQ
-------------------
KS
V
Y
G
Y
G
MC
S
D
P
--
L
Y
T
K
DDDALKASP
C
LSIPQSEWN
H
T
L
T
R
-
--
Q
Y
------
VI
D
NE
K
L
ENF
S
V
D
TQ
L
QS
KF
AT
GSV
E
H
T
L
LT
G
V
----------
D
F
MR
MR
N
------------
D
I
DSW
F
G
YA
G
S
V
A
PS
D
-
I
--
Y
NL
-------------
DRSD
-
FD
FGAH-PDPSGPYRV
L
L
KQ
K
Q
T
-
-
-
G
L
Y
VQ
D
QAQ
W
-
D
KVLVT
LG
G
R
-------
Y
DWAE
Q
-
SSFN
R
--------------
DYGNKS
-----
DR
DD
K
QF
----
T
W
RG
G
VNY
L
F
D
N
GVT
P
Y
F
SY
S
E
SF
E
P
---------
A
S
-
LT
D
AN
G
DL
-
F
A
P
S
K
G
KQ
YE
-------
V
G
V
K
YVPE
D
RP
IV
L
T
G
A
L
Y
Q
L
T
K
T
N
NL
M
A
DP
-
N
NP
N
F
SIEG
GE
I
R
--------
AR
GVE
L
E
AK
---
A
AL
S
A
SVN
V
VG
SYTY
T
DAE
YT
--
TDTTY
K
G
-
N
TP
AQV
P
-----
KHMASLW
A
D
Y
T
F
F
DG
P
L
SG
-
LT
L
G
-----
T
G
G
R
Y
TG
--
S
S
Y
---
GD
P
A
N
-
S
F
K
V
--
GSY
T
V
VD
ALV
RY
D
LARVGMA
GS
N
VALH
VNNLFD
RE
Y
V
AS
CF
--
NT
YG
CF
W
GA
E
R
Q
V
VA
T
A
T
F
R
F
fig|749527.3.peg.3258
Escherichia coli MS 21-1 (16-752/752)
IAV
V
V
A
T
A
V
-----
-
SG
MS
---
-
-----
-
---
V
Y
A
Q
A
A
V
E
P
KE-
D
T
IT
VTA
-
A
P
---
AP
Q
E
SAW
G
-
-
P
A
A
T
IAARQSAT
GTK
TDT
P
IQ
KV
PQS
IS
VV
T
A
E
E
M
A
L
H
Q
PK
SV
K
E
A
L
S
Y
TPGV
---
A
V
G
T
R
GAS
N
T
Y
D
YLI
I
RGF
-
AA
D
GQ
SQ
N
NY
L
--
-
N
G
L
K
-
MQGNF
Y
N
--
DA
VI
D
P
-
YM
L
ER
A
E
I
M
RGP
V
S
V
L
YG
KS
S
PGG
LL
NMV
S
KR
P
T
TEP
LKE
I
-----
Q
--
FK
A
------
G
T
D
SL
FQ
T
GF
D
F
S
DA
L
DD
DG
VYS
Y
R
LT
G
IA
R
S
A
N
A
Q
QKGAE
E
Q
R
YAIAPA
--
F
TW
RP
D
-
D
K
T
NF
T
F
LS
Y
-
FQN
E
------
P
E
T
G
YYGW
-
LP
KE
GT
V
-----
-E
P
L
--
PN
GK
--
RL
P
TDF
N
E
G
AK
N
NTYSRNEK
M
V
GY
S
F
D
H
E
F
N
DT
FTVR
Q
N
LR
F
AQ
N
K
--
-----
-
V
SQ
-------------------
KS
V
Y
G
Y
G
MC
S
D
P
--
L
Y
T
K
DDDALKASP
C
LSIPQSEWN
H
T
L
T
R
-
--
Q
Y
------
VI
D
NE
K
L
ENF
S
V
D
TQ
L
QS
KF
AT
GSV
E
H
T
L
LT
G
V
----------
D
F
MR
MR
N
------------
D
I
DSW
F
G
YA
G
S
V
A
PS
D
-
I
--
Y
NL
-------------
DRSD
-
FD
FGAH-PDPSGPYRV
L
L
KQ
K
Q
T
-
-
-
G
L
Y
VQ
D
QAQ
W
-
D
KVLVT
LG
G
R
-------
Y
DWAE
Q
-
SSFN
R
--------------
DYGNKS
-----
DR
DD
K
QF
----
T
W
RG
G
VNY
L
F
D
N
GVT
P
Y
F
SY
S
E
SF
E
P
---------
A
S
-
LT
D
AN
G
DL
-
F
A
P
S
K
G
KQ
YE
-------
V
G
V
K
YVPE
D
RP
IV
L
T
G
A
L
Y
Q
L
T
K
T
N
NL
M
A
DP
-
N
NP
N
F
SIEG
GE
I
R
--------
AR
GVE
L
E
AK
---
A
AL
S
A
SVN
V
VG
SYTY
T
DAE
YT
--
TDTTY
K
G
-
N
TP
AQV
P
-----
KHMASLW
A
D
Y
T
F
F
DG
P
L
SG
-
LT
L
G
-----
T
G
G
R
Y
TG
--
S
S
Y
---
GD
P
A
N
-
S
F
K
V
--
GSY
T
V
VD
ALV
RY
D
LARVGMA
GS
N
VALH
VNNLFD
RE
Y
V
AS
CF
--
NT
YG
CF
W
GA
E
R
Q
V
VA
T
A
T
F
R
F
fig|749537.3.peg.3254
Escherichia coli MS 115-1 (16-747/747)
IAV
V
V
A
T
A
V
-----
-
SG
MS
---
-
-----
-
---
V
Y
A
Q
A
A
V
E
P
KE-
D
T
IT
VTA
-
A
P
---
AP
Q
E
SAW
G
-
-
P
A
A
T
IAARQSAT
GTK
TDT
P
IQ
KV
PQS
IS
VV
T
A
E
E
M
A
L
H
Q
PK
SV
K
E
A
L
S
Y
TPGV
---
S
V
G
T
R
GAS
N
T
Y
D
HLI
I
RGF
-
AAEGQ
SQ
N
NY
L
--
-
N
G
L
K
-
LQGNF
Y
N
--
DA
VI
D
P
-
YM
L
ER
A
E
I
M
RGP
V
S
V
L
YG
KS
S
PGG
LL
NMV
S
KR
P
T
TEP
LKEV
-----
Q
--
FK
A
------
G
T
D
SL
FQ
T
GF
D
F
S
DA
L
DD
DG
VYS
Y
R
LT
G
LA
R
S
A
N
A
Q
QKGSE
E
Q
R
YAIAPA
--
F
TW
RP
D
-
D
K
T
NF
T
V
LS
Y
-
FQN
E
------
P
E
T
G
YYGW
-
LP
KE
GT
V
-----
-E
P
L
--
PN
GK
--
RL
P
TDF
N
E
G
AK
N
NTYSRNEK
M
V
GY
S
F
D
H
E
F
N
DT
FTVR
Q
N
LR
F
A
E
N
K
--
-----
-
T
SQ
-------------------
NS
V
Y
G
Y
G
VC
S
D
PANAYSKQ
--------
CAALAPADKGH
Y
L
A
R
-
--
KY
------
VV
D
DE
K
L
QNF
S
V
D
TQ
L
QS
KF
AT
GDI
D
H
T
L
LT
G
V
----------
D
F
MR
MR
N
------------
D
I
NAW
F
G
YD
DS
V
P
LL
N
-
L
--
Y
N
P
-------------
VNTD
-
FD
FNAKDPANSGPYRI
L
N
KQ
K
Q
T
-
-
-
G
V
Y
VQ
D
QAQ
W
-
D
KVLVT
LG
G
R
-------
Y
DWAD
Q
-
ESLN
R
--------------
VAGTTD
-----
KR
DD
K
QF
----
T
W
RG
G
VNY
L
F
D
N
GVT
P
Y
F
SY
S
E
SF
E
P
---------
S
S
-
QV
G
KD
G
NI
-
F
A
P
S
K
G
KQ
YE
-------
V
G
V
K
YVPE
D
RP
IV
V
T
G
A
V
Y
N
L
T
K
T
N
NL
M
A
DP
-
E
G
S
F
F
SVEG
GE
I
R
--------
AR
GVE
I
E
AK
---
A
AL
S
A
SVN
V
VG
SYTY
T
DAE
YT
--
TDTTY
K
G
-
N
TP
AQV
P
-----
KHMASLW
A
D
Y
T
F
F
DG
P
L
SG
-
LT
L
G
-----
T
G
G
R
Y
TG
--
S
S
Y
---
GD
P
A
N
-
S
F
K
V
--
GSY
T
V
VD
ALV
RY
D
LARVGMA
GS
N
VALH
VNNLFD
RE
Y
V
AS
CF
--
NT
YG
CF
W
GA
E
R
Q
V
VA
T
A
T
F
R
F
fig|358709.5.peg.3852
Escherichia coli 101-1 (16-747/747)
IAV
V
V
A
T
A
V
-----
-
SG
MS
---
-
-----
-
---
V
Y
A
Q
A
A
V
E
P
KE-
D
T
IT
VTA
-
A
P
---
AP
Q
E
SAW
G
-
-
P
A
A
T
IAARQSAT
GTK
TDT
P
IQ
KV
PQS
IS
VV
T
A
E
E
M
A
L
H
Q
PK
SV
K
E
A
L
S
Y
TPGV
---
S
V
G
T
R
GAS
N
T
Y
D
HLI
I
RGF
-
AAEGQ
SQ
N
NY
L
--
-
N
G
L
K
-
LQGNF
Y
N
--
DA
VI
D
P
-
YM
L
ER
A
E
I
M
RGP
V
S
V
L
YG
KS
S
PGG
LL
NMV
S
KR
P
T
TEP
LKEV
-----
Q
--
FK
A
------
G
T
D
SL
FQ
T
GF
D
F
S
DA
L
DD
DG
VYS
Y
R
LT
G
LA
R
S
A
N
A
Q
QKGSE
E
Q
R
YAIAPA
--
F
TW
RP
D
-
D
K
T
NF
T
F
LS
Y
-
FQN
E
------
P
E
T
G
YYGW
-
LP
KE
GT
V
-----
-E
P
L
--
PN
GK
--
RL
P
TDF
N
E
G
AK
N
NTYSRNEK
M
V
GY
S
F
D
H
E
F
N
DT
FTVR
Q
N
LR
F
A
E
N
K
--
-----
-
T
SQ
-------------------
NS
V
Y
G
Y
G
VC
S
D
PANAYSKQ
--------
CAALAPADKGH
Y
L
A
R
-
--
KY
------
VV
D
DE
K
L
QNF
S
V
D
TQ
L
QS
KF
AT
GDI
D
H
T
L
LT
G
V
----------
D
F
MR
MR
N
------------
D
I
NAW
F
G
YD
DS
V
P
LL
N
-
L
--
Y
N
P
-------------
VNTD
-
FD
FNAKDPANSGPYRI
L
N
KQ
K
Q
T
-
-
-
G
V
Y
VQ
D
QAQ
W
-
D
KVLVT
LG
G
R
-------
Y
DWAD
Q
-
ESLN
R
--------------
VAGTTD
-----
KR
DD
K
QF
----
T
W
RG
G
VNY
L
F
D
N
GVT
P
Y
F
SY
S
E
SF
E
P
---------
S
S
-
QV
G
KD
G
NI
-
F
A
P
S
K
G
KQ
YE
-------
V
G
V
K
YVPE
D
RP
IV
V
T
G
A
V
Y
N
L
T
K
T
N
NL
M
A
DP
-
E
G
S
F
F
SVEG
GE
I
R
--------
AR
GVE
I
E
AK
---
A
AL
S
A
SVN
V
VG
SYTY
T
DAE
YT
--
TDTTY
K
G
-
N
TP
AQV
P
-----
KHMASLW
A
D
Y
T
F
F
DG
P
L
SG
-
LT
L
G
-----
T
G
G
R
Y
TG
--
S
S
Y
---
GD
P
A
N
-
S
F
K
V
--
GSY
T
V
VD
ALV
RY
D
LARVGMA
GS
N
VALH
VNNLFD
RE
Y
V
AS
CF
--
NT
YG
CF
W
GA
E
R
Q
V
VA
T
A
T
F
R
F
fig|670888.3.peg.735
Escherichia coli 1827-70 (16-747/747)
IAV
V
V
A
T
A
V
-----
-
SG
MS
---
-
-----
-
---
V
Y
A
Q
A
A
V
E
P
KE-
D
T
IT
VTA
-
A
P
---
AP
Q
E
SAW
G
-
-
P
A
A
T
IAARQSAT
GTK
TDT
P
IQ
KV
PQS
IS
VV
T
A
E
E
M
A
L
H
Q
PK
SV
K
E
A
L
S
Y
TPGV
---
S
V
G
T
R
GAS
N
T
Y
D
HLI
I
RGF
-
AAEGQ
SQ
N
NY
L
--
-
N
G
L
K
-
LQGNF
Y
N
--
DA
VI
D
P
-
YM
L
ER
A
E
I
M
RGP
V
S
V
L
YG
KS
S
PGG
LL
NMV
S
KR
P
T
TEP
LKEV
-----
Q
--
FK
A
------
G
T
D
SL
FQ
T
GF
D
F
S
DA
L
DD
DG
VYS
Y
R
LT
G
LA
R
S
A
N
A
Q
QKGSE
E
Q
R
YAIAPA
--
F
TW
RP
D
-
D
K
T
NF
T
F
LS
Y
-
FQN
E
------
P
E
T
G
YYGW
-
LP
KE
GT
V
-----
-E
P
L
--
PN
GK
--
RL
P
TDF
N
E
G
AK
N
NTYSRNEK
M
V
GY
S
F
D
H
E
F
N
DT
FTVR
Q
N
LR
F
A
E
N
K
--
-----
-
T
SQ
-------------------
NS
V
Y
G
Y
G
VC
S
D
PANAYSKQ
--------
CAALAPADKGH
Y
L
A
R
-
--
KY
------
VV
D
DE
K
L
QNF
S
V
D
TQ
L
QS
KF
AT
GDI
D
H
T
L
LT
G
V
----------
D
F
MR
MR
N
------------
D
I
NAW
F
G
YD
DS
V
P
LL
N
-
L
--
Y
N
P
-------------
VNTD
-
FD
FNAKDPANSGPYRI
L
N
KQ
K
Q
T
-
-
-
G
V
Y
VQ
D
QAQ
W
-
D
KVLVT
LG
G
R
-------
Y
DWAD
Q
-
ESLN
R
--------------
VAGTTD
-----
KR
DD
K
QF
----
T
W
RG
G
VNY
L
F
D
N
GVT
P
Y
F
SY
S
E
SF
E
P
---------
S
S
-
QV
G
KD
G
NI
-
F
A
P
S
K
G
KQ
YE
-------
V
G
V
K
YVPE
D
RP
IV
V
T
G
A
V
Y
N
L
T
K
T
N
NL
M
A
DP
-
E
G
S
F
F
SVEG
GE
I
R
--------
AR
GVE
I
E
AK
---
A
AL
S
A
SVN
V
VG
SYTY
T
DAE
YT
--
TDTTY
K
G
-
N
TP
AQV
P
-----
KHMASLW
A
D
Y
T
F
F
DG
P
L
SG
-
LT
L
G
-----
T
G
G
R
Y
TG
--
S
S
Y
---
GD
P
A
N
-
S
F
K
V
--
GSY
T
V
VD
ALV
RY
D
LARVGMA
GS
N
VALH
VNNLFD
RE
Y
V
AS
CF
--
NT
YG
CF
W
GA
E
R
Q
V
VA
T
A
T
F
R
F
fig|344610.3.peg.4055
Escherichia coli 53638 (16-747/747)
IAV
V
V
A
T
A
V
-----
-
SG
MS
---
-
-----
-
---
V
Y
A
Q
A
A
V
E
P
KE-
D
T
IT
VTA
-
A
P
---
AP
Q
E
SAW
G
-
-
P
A
A
T
IAARQSAT
GTK
TDT
P
IQ
KV
PQS
IS
VV
T
A
E
E
M
A
L
H
Q
PK
SV
K
E
A
L
S
Y
TPGV
---
S
V
G
T
R
GAS
N
T
Y
D
HLI
I
RGF
-
AAEGQ
SQ
N
NY
L
--
-
N
G
L
K
-
LQGNF
Y
N
--
DA
VI
D
P
-
YM
L
ER
A
E
I
M
RGP
V
S
V
L
YG
KS
S
PGG
LL
NMV
S
KR
P
T
TEP
LKEV
-----
Q
--
FK
A
------
G
T
D
SL
FQ
T
GF
D
F
S
DA
L
DD
DG
VYS
Y
R
LT
G
LA
R
S
A
N
A
Q
QKGSE
E
Q
R
YAIAPA
--
F
TW
RP
D
-
D
K
T
NF
T
F
LS
Y
-
FQN
E
------
P
E
T
G
YYGW
-
LP
KE
GT
V
-----
-E
P
L
--
PN
GK
--
RL
P
TDF
N
E
G
AK
N
NTYSRNEK
M
V
GY
S
F
D
H
E
F
N
DT
FTVR
Q
N
LR
F
A
E
N
K
--
-----
-
T
SQ
-------------------
NS
V
Y
G
Y
G
VC
S
D
PANAYSKQ
--------
CAALAPADKGH
Y
L
A
R
-
--
KY
------
VV
D
DE
K
L
QNF
S
V
D
TQ
L
QS
KF
AT
GDI
D
H
T
L
LT
G
V
----------
D
F
MR
MR
N
------------
D
I
NAW
F
G
YD
DS
V
P
LL
N
-
L
--
Y
N
P
-------------
VNTD
-
FD
FNAKDPANSGPYRI
L
N
KQ
K
Q
T
-
-
-
G
V
Y
VQ
D
QAQ
W
-
D
KVLVT
LG
G
R
-------
Y
DWAD
Q
-
ESLN
R
--------------
VAGTTD
-----
KR
DD
K
QF
----
T
W
RG
G
VNY
L
F
D
N
GVT
P
Y
F
SY
S
E
SF
E
P
---------
S
S
-
QV
G
KD
G
NI
-
F
A
P
S
K
G
KQ
YE
-------
V
G
V
K
YVPE
D
RP
IV
V
T
G
A
V
Y
N
L
T
K
T
N
NL
M
A
DP
-
E
G
S
F
F
SVEG
GE
I
R
--------
AR
GVE
I
E
AK
---
A
AL
S
A
SVN
V
VG
SYTY
T
DAE
YT
--
TDTTY
K
G
-
N
TP
AQV
P
-----
KHMASLW
A
D
Y
T
F
F
DG
P
L
SG
-
LT
L
G
-----
T
G
G
R
Y
TG
--
S
S
Y
---
GD
P
A
N
-
S
F
K
V
--
GSY
T
V
VD
ALV
RY
D
LARVGMA
GS
N
VALH
VNNLFD
RE
Y
V
AS
CF
--
NT
YG
CF
W
GA
E
R
Q
V
VA
T
A
T
F
R
F
fig|481805.3.peg.3772
Escherichia coli ATCC 8739 (16-747/747)
IAV
V
V
A
T
A
V
-----
-
SG
MS
---
-
-----
-
---
V
Y
A
Q
A
A
V
E
P
KE-
D
T
IT
VTA
-
A
P
---
AP
Q
E
SAW
G
-
-
P
A
A
T
IAARQSAT
GTK
TDT
P
IQ
KV
PQS
IS
VV
T
A
E
E
M
A
L
H
Q
PK
SV
K
E
A
L
S
Y
TPGV
---
S
V
G
T
R
GAS
N
T
Y
D
HLI
I
RGF
-
AAEGQ
SQ
N
NY
L
--
-
N
G
L
K
-
LQGNF
Y
N
--
DA
VI
D
P
-
YM
L
ER
A
E
I
M
RGP
V
S
V
L
YG
KS
S
PGG
LL
NMV
S
KR
P
T
TEP
LKEV
-----
Q
--
FK
A
------
G
T
D
SL
FQ
T
GF
D
F
S
DA
L
DD
DG
VYS
Y
R
LT
G
LA
R
S
A
N
A
Q
QKGSE
E
Q
R
YAIAPA
--
F
TW
RP
D
-
D
K
T
NF
T
F
LS
Y
-
FQN
E
------
P
E
T
G
YYGW
-
LP
KE
GT
V
-----
-E
P
L
--
PN
GK
--
RL
P
TDF
N
E
G
AK
N
NTYSRNEK
M
V
GY
S
F
D
H
E
F
N
DT
FTVR
Q
N
LR
F
A
E
N
K
--
-----
-
T
SQ
-------------------
NS
V
Y
G
Y
G
VC
S
D
PANAYSKQ
--------
CAALAPADKGH
Y
L
A
R
-
--
KY
------
VV
D
DE
K
L
QNF
S
V
D
TQ
L
QS
KF
AT
GDI
D
H
T
L
LT
G
V
----------
D
F
MR
MR
N
------------
D
I
NAW
F
G
YD
DS
V
P
LL
N
-
L
--
Y
N
P
-------------
VNTD
-
FD
FNAKDPANSGPYRI
L
N
KQ
K
Q
T
-
-
-
G
V
Y
VQ
D
QAQ
W
-
D
KVLVT
LG
G
R
-------
Y
DWAD
Q
-
ESLN
R
--------------
VAGTTD
-----
KR
DD
K
QF
----
T
W
RG
G
VNY
L
F
D
N
GVT
P
Y
F
SY
S
E
SF
E
P
---------
S
S
-
QV
G
KD
G
NI
-
F
A
P
S
K
G
KQ
YE
-------
V
G
V
K
YVPE
D
RP
IV
V
T
G
A
V
Y
N
L
T
K
T
N
NL
M
A
DP
-
E
G
S
F
F
SVEG
GE
I
R
--------
AR
GVE
I
E
AK
---
A
AL
S
A
SVN
V
VG
SYTY
T
DAE
YT
--
TDTTY
K
G
-
N
TP
AQV
P
-----
KHMASLW
A
D
Y
T
F
F
DG
P
L
SG
-
LT
L
G
-----
T
G
G
R
Y
TG
--
S
S
Y
---
GD
P
A
N
-
S
F
K
V
--
GSY
T
V
VD
ALV
RY
D
LARVGMA
GS
N
VALH
VNNLFD
RE
Y
V
AS
CF
--
NT
YG
CF
W
GA
E
R
Q
V
VA
T
A
T
F
R
F
fig|481805.6.peg.3749
Escherichia coli ATCC 8739 (16-747/747)
IAV
V
V
A
T
A
V
-----
-
SG
MS
---
-
-----
-
---
V
Y
A
Q
A
A
V
E
P
KE-
D
T
IT
VTA
-
A
P
---
AP
Q
E
SAW
G
-
-
P
A
A
T
IAARQSAT
GTK
TDT
P
IQ
KV
PQS
IS
VV
T
A
E
E
M
A
L
H
Q
PK
SV
K
E
A
L
S
Y
TPGV
---
S
V
G
T
R
GAS
N
T
Y
D
HLI
I
RGF
-
AAEGQ
SQ
N
NY
L
--
-
N
G
L
K
-
LQGNF
Y
N
--
DA
VI
D
P
-
YM
L
ER
A
E
I
M
RGP
V
S
V
L
YG
KS
S
PGG
LL
NMV
S
KR
P
T
TEP
LKEV
-----
Q
--
FK
A
------
G
T
D
SL
FQ
T
GF
D
F
S
DA
L
DD
DG
VYS
Y
R
LT
G
LA
R
S
A
N
A
Q
QKGSE
E
Q
R
YAIAPA
--
F
TW
RP
D
-
D
K
T
NF
T
F
LS
Y
-
FQN
E
------
P
E
T
G
YYGW
-
LP
KE
GT
V
-----
-E
P
L
--
PN
GK
--
RL
P
TDF
N
E
G
AK
N
NTYSRNEK
M
V
GY
S
F
D
H
E
F
N
DT
FTVR
Q
N
LR
F
A
E
N
K
--
-----
-
T
SQ
-------------------
NS
V
Y
G
Y
G
VC
S
D
PANAYSKQ
--------
CAALAPADKGH
Y
L
A
R
-
--
KY
------
VV
D
DE
K
L
QNF
S
V
D
TQ
L
QS
KF
AT
GDI
D
H
T
L
LT
G
V
----------
D
F
MR
MR
N
------------
D
I
NAW
F
G
YD
DS
V
P
LL
N
-
L
--
Y
N
P
-------------
VNTD
-
FD
FNAKDPANSGPYRI
L
N
KQ
K
Q
T
-
-
-
G
V
Y
VQ
D
QAQ
W
-
D
KVLVT
LG
G
R
-------
Y
DWAD
Q
-
ESLN
R
--------------
VAGTTD
-----
KR
DD
K
QF
----
T
W
RG
G
VNY
L
F
D
N
GVT
P
Y
F
SY
S
E
SF
E
P
---------
S
S
-
QV
G
KD
G
NI
-
F
A
P
S
K
G
KQ
YE
-------
V
G
V
K
YVPE
D
RP
IV
V
T
G
A
V
Y
N
L
T
K
T
N
NL
M
A
DP
-
E
G
S
F
F
SVEG
GE
I
R
--------
AR
GVE
I
E
AK
---
A
AL
S
A
SVN
V
VG
SYTY
T
DAE
YT
--
TDTTY
K
G
-
N
TP
AQV
P
-----
KHMASLW
A
D
Y
T
F
F
DG
P
L
SG
-
LT
L
G
-----
T
G
G
R
Y
TG
--
S
S
Y
---
GD
P
A
N
-
S
F
K
V
--
GSY
T
V
VD
ALV
RY
D
LARVGMA
GS
N
VALH
VNNLFD
RE
Y
V
AS
CF
--
NT
YG
CF
W
GA
E
R
Q
V
VA
T
A
T
F
R
F
fig|749547.3.peg.4145
Escherichia coli MS 187-1 (16-747/747)
IAV
V
V
A
T
A
V
-----
-
SG
MS
---
-
-----
-
---
V
Y
A
Q
A
A
V
E
P
KE-
D
T
IT
VTA
-
A
P
---
AP
Q
E
SAW
G
-
-
P
A
A
T
IAARQSAT
GTK
TDT
P
IQ
KV
PQS
IS
VV
T
A
E
E
M
A
L
H
Q
PK
SV
K
E
A
L
S
Y
TPGV
---
S
V
G
T
R
GAS
N
T
Y
D
HLI
I
RGF
-
AAEGQ
SQ
N
NY
L
--
-
N
G
L
K
-
LQGNF
Y
N
--
DA
VI
D
P
-
YM
L
ER
A
E
I
M
RGP
V
S
V
L
YG
KS
S
PGG
LL
NMV
S
KR
P
T
TEP
LKEV
-----
Q
--
FK
A
------
G
T
D
SL
FQ
T
GF
D
F
S
DA
L
DD
DG
VYS
Y
R
LT
G
LA
R
S
A
N
A
Q
QKGSE
E
Q
R
YAIAPA
--
F
TW
RP
D
-
D
K
T
NF
T
F
LS
Y
-
FQN
E
------
P
E
T
G
YYGW
-
LP
KE
GT
V
-----
-E
P
L
--
PN
GK
--
RL
P
TDF
N
E
G
AK
N
NTYSRNEK
M
V
GY
S
F
D
H
E
F
N
DT
FTVR
Q
N
LR
F
A
E
N
K
--
-----
-
T
SQ
-------------------
NS
V
Y
G
Y
G
VC
S
D
PANAYSKQ
--------
CAALAPADKGH
Y
L
A
R
-
--
KY
------
VV
D
DE
K
L
QNF
S
V
D
TQ
L
QS
KF
AT
GDI
D
H
T
L
LT
G
V
----------
D
F
MR
MR
N
------------
D
I
NAW
F
G
YD
DS
V
P
LL
N
-
L
--
Y
N
P
-------------
VNTD
-
FD
FNAKDPANSGPYRI
L
N
KQ
K
Q
T
-
-
-
G
V
Y
VQ
D
QAQ
W
-
D
KVLVT
LG
G
R
-------
Y
DWAD
Q
-
ESLN
R
--------------
VAGTTD
-----
KR
DD
K
QF
----
T
W
RG
G
VNY
L
F
D
N
GVT
P
Y
F
SY
S
E
SF
E
P
---------
S
S
-
QV
G
KD
G
NI
-
F
A
P
S
K
G
KQ
YE
-------
V
G
V
K
YVPE
D
RP
IV
V
T
G
A
V
Y
N
L
T
K
T
N
NL
M
A
DP
-
E
G
S
F
F
SVEG
GE
I
R
--------
AR
GVE
I
E
AK
---
A
AL
S
A
SVN
V
VG
SYTY
T
DAE
YT
--
TDTTY
K
G
-
N
TP
AQV
P
-----
KHMASLW
A
D
Y
T
F
F
DG
P
L
SG
-
LT
L
G
-----
T
G
G
R
Y
TG
--
S
S
Y
---
GD
P
A
N
-
S
F
K
V
--
GSY
T
V
VD
ALV
RY
D
LARVGMA
GS
N
VALH
VNNLFD
RE
Y
V
AS
CF
--
NT
YG
CF
W
GA
E
R
Q
V
VA
T
A
T
F
R
F
fig|550677.3.peg.540
Escherichia coli B354 (16-747/747)
IAV
V
V
A
T
A
V
-----
-
SG
MS
---
-
-----
-
---
V
Y
A
Q
A
A
V
E
P
KE-
D
T
IT
VTA
-
A
P
---
AP
Q
E
SAW
G
-
-
P
A
A
T
IAARQSAT
GTK
TDT
P
IQ
KV
PQS
IS
VV
T
A
E
E
M
A
L
H
Q
PK
SV
K
E
A
L
S
Y
TPGV
---
S
V
G
T
R
GAS
N
T
Y
D
HLI
I
RGF
-
AAEGQ
SQ
N
NY
L
--
-
N
G
L
K
-
LQGNF
Y
N
--
DA
VI
D
P
-
YM
L
ER
A
E
I
M
RGP
V
S
V
L
YG
KS
S
PGG
LL
NMV
S
KR
P
T
TEP
LKEV
-----
Q
--
FK
A
------
G
T
D
SL
FQ
T
GF
D
F
S
DA
L
DD
DG
VYS
Y
R
L
I
G
LA
R
S
A
N
A
Q
QKGSE
E
Q
R
YAIAPA
--
F
TW
RP
D
-
D
K
T
NF
T
F
LS
Y
-
FQN
E
------
P
E
T
G
YYGW
-
LP
KE
GT
V
-----
-E
P
L
--
PN
GK
--
RL
P
TDF
N
E
G
AK
N
NTYSRNEK
M
V
GY
S
F
D
H
E
F
N
DT
FTVR
Q
N
LR
F
A
E
N
K
--
-----
-
T
SQ
-------------------
NS
V
Y
G
Y
G
VC
S
D
PANAYSKQ
--------
CAALAPADKGH
Y
L
A
R
-
--
KY
------
VV
D
DE
K
L
QNF
S
V
D
TQ
L
QS
QF
AT
GDI
D
H
T
L
LT
G
V
----------
D
F
MR
MR
N
------------
D
I
NAW
F
G
YD
DS
V
P
LL
D
-
L
--
Y
N
P
-------------
VNTD
-
FD
FNAKDPANSGPYRI
L
N
KQ
K
Q
T
-
-
-
G
V
Y
VQ
D
QAQ
W
-
D
KVLVT
LG
G
R
-------
Y
DWAD
Q
-
ESLN
R
--------------
VAGTTD
-----
KR
DD
K
QF
----
T
W
RG
G
VNY
L
F
D
N
GVT
P
Y
F
SY
S
E
SF
E
P
---------
S
S
-
QV
G
KD
G
NI
-
F
A
P
S
K
G
KQ
YE
-------
V
G
V
K
YVPE
D
RP
IV
V
T
G
A
V
Y
N
L
T
K
T
N
NL
M
A
DP
-
E
G
S
F
F
SVEG
GE
I
R
--------
AR
GVE
I
E
AK
---
A
AL
S
A
SVN
V
VG
SYTY
T
DAE
YT
--
TDTTY
K
G
-
N
TP
AQV
P
-----
KHMASLW
A
D
Y
T
F
F
DG
P
L
SG
-
LT
L
G
-----
T
G
G
R
Y
TG
--
S
S
Y
---
GD
P
A
N
-
S
F
K
V
--
GSY
T
V
VD
ALV
RY
D
LARVGMA
GS
N
VALH
VNNLFD
RE
Y
V
AS
CF
--
NT
YG
CF
W
GA
E
R
Q
V
VA
T
A
T
F
R
F
fig|656444.3.peg.491
Escherichia coli TA280 (16-747/747)
IAV
V
V
A
T
A
V
-----
-
SG
MS
---
-
-----
-
---
V
Y
A
Q
A
A
V
E
P
KE-
D
T
IT
VTA
-
A
P
---
AP
Q
E
SAW
G
-
-
P
A
A
T
IAARQSAT
GTK
TDT
P
IQ
KV
PQS
IS
VV
T
A
E
E
M
A
L
H
Q
PK
SV
K
E
A
L
S
Y
TPGV
---
S
V
G
T
R
GAS
N
T
Y
D
HLI
I
RGF
-
AAEGQ
SQ
N
NY
L
--
-
N
G
L
K
-
LQGNF
Y
N
--
DA
VI
D
P
-
YM
L
ER
A
E
I
M
RGP
V
S
V
L
YG
KS
S
PGG
LL
NMV
S
KR
P
T
TEP
LKEV
-----
Q
--
FK
A
------
G
T
D
SL
FQ
T
GF
D
F
S
DA
L
DD
DG
VYS
Y
R
LT
G
LA
R
S
A
N
A
Q
QKGSE
E
Q
R
YAIAPA
--
FS
W
RP
D
-
D
K
T
NF
T
F
LS
Y
-
FQN
E
------
P
E
T
G
YYGW
-
LP
KE
GT
V
-----
-E
P
L
--
PN
GK
--
RL
P
TDF
N
E
G
AK
N
NTYSRNEK
M
V
GY
S
F
D
H
E
F
N
DT
FTVR
Q
N
LR
F
A
E
N
K
--
-----
-
T
SQ
-------------------
NS
V
Y
G
Y
G
VC
S
D
PANAYSKQ
--------
CAALAPADKGH
Y
L
A
R
-
--
KY
------
VV
D
DE
K
L
QNF
S
V
D
TQ
L
QS
QF
AT
GDI
D
H
T
L
LT
G
V
----------
D
F
MR
MR
N
------------
D
I
NAW
F
G
YD
DS
I
P
LL
D
-
L
--
Y
N
P
-------------
VNTD
-
FD
FNAKDPANSGPYRI
L
N
KQ
K
Q
T
-
-
-
G
V
Y
VQ
D
QAQ
W
-
D
KVLVT
LG
G
R
-------
Y
DWAD
Q
-
ESLN
R
--------------
VAGTTD
-----
KR
DD
K
QF
----
T
W
RG
G
VNY
L
F
D
N
GVT
P
Y
F
SY
S
E
SF
E
P
---------
S
S
-
QV
G
KD
G
NI
-
F
A
P
S
K
G
KQ
YE
-------
V
G
V
K
YVPE
D
RP
IV
V
T
G
A
V
Y
N
L
T
K
T
N
NL
M
A
DP
-
E
G
S
F
F
SVEG
GE
I
R
--------
AR
GVE
I
E
AK
---
A
AL
S
A
SVN
V
VG
SYTY
T
DAE
YT
--
TDTTY
K
G
-
N
TP
AQV
P
-----
KHMASLW
A
D
Y
T
F
F
DG
P
L
SG
-
LT
L
G
-----
T
G
G
R
Y
TG
--
S
S
Y
---
GD
P
A
N
-
S
F
K
V
--
GSY
T
V
VD
ALV
RY
D
LARVGMA
GS
N
VALH
VNNLFD
RE
Y
V
AS
CF
--
NT
YG
CF
W
GA
E
R
Q
V
VA
T
A
T
F
R
F
fig|670897.3.peg.1978
Escherichia coli 2362-75 (16-731/731)
IAV
V
V
A
T
A
V
-----
-
SG
MS
---
-
-----
-
---
V
Y
A
Q
A
A
V
E
P
KE-
D
T
IT
VTA
-
A
P
---
AP
Q
E
SAW
G
-
-
P
A
A
T
IAA
KH
SAT
A
TK
TDT
P
IE
K
T
PQS
IS
VV
T
R
E
E
M
D
I
K
Q
PA
T
V
K
E
A
L
D
Y
TP
S
V
---
-
F
S
T
R
G
S
S
T
T
Y
D
VVS
I
RGF
TT
A
STV
NT
N
Q
Y
L
--
-
DG
L
K
-
LQGDN
YS
--
E
A
SI
D
P
-
Y
F
L
ERVE
LL
RGP
V
S
V
L
YG
KS
H
PGG
V
VS
MV
S
KR
P
S
TDP
I
KE
I
-----
Q
--
FK
M
------
G
T
D
N
L
WQ
T
GF
D
F
S
DA
I
DD
DG
VWS
Y
R
LT
G
LG
R
S
Q
D
A
Q
QKYAK
T
T
R
YA
V
AP
S
--
FS
W
RP
D
-
D
K
T
DF
T
F
LS
N
-
FQS
D
------
P
D
A
G
YYGW
-
LP
RQ
GT
V
-----
-V
P
Y
QDA
N
GS
WH
KL
P
TDF
N
E
G
EK
DN
KM
SR
RQQ
L
I
GY
S
F
A
H
E
F
N
DT
FTVR
Q
N
LR
YT
R
I
H
--
-----
-
T
L
Y
-------------------
DA
V
Y
G
N
G
YI
A
P
A
--------------------------
Q
I
S
R
-
--
A
Y
------
VR
S
DE
D
L
NSF
T
V
D
TQ
L
QS
NF
A
I
GAV
A
H
T
L
LT
G
V
----------
D
Y
L
R
MR
N
------------
D
I
DAN
YG
TA
NP
I
S
MT
D
P
Q
--
Y
GN
-------------
ANIN
-
IN
F---------PYAV
I
N
R
Q
E
Q
T
-
-
-
G
L
Y
I
Q
D
QSE
W
-
N
KWVLT
LG
G
R
-------
Y
DFAK
T
-
STYT
R
--------------
STSSLD
-----
EI
N
D
Q
QF
----
T
W
RG
G
I
NY
L
F
D
N
G
I
S
P
Y
F
SY
S
E
SF
E
P
---------
V
S
-
GA
T
KE
G
KP
-
F
D
P
S
R
G
KQ
YE
-------
A
G
V
K
YVPK
D
TP
V
T
V
T
A
SV
F
Q
L
T
K
D
K
NL
T
A
DP
-
S
N
T
L
F
SVQG
GE
I
R
--------
S
R
G
F
E
I
E
AK
---
A
A
V
N
A
N
I
N
V
TA
A
Y
S
Y
T
DAE
YT
--
K
DT
L
Y
K
G
-
K
RP
A
E
V
P
-----
R
N
MASLW
A
D
Y
T
F
H
ETA
L
SG
-
L
S
L
G
-----
A
G
A
R
Y
FG
D
T
S
S
F
YT
T
GD
KT
N
Q
TF
N
V
--
G
G
Y
T
LVD
A
MI
K
Y
D
I
AR
F
GM
P
GS
S
V
GV
NVNNLFD
RE
Y
V
S
S
CY
--
RD
Y
A
CY
W
GA
E
R
Q
V
VA
T
A
T
F
R
F
fig|656393.3.peg.769
Escherichia coli H299 (16-729/729)
IAV
V
V
A
T
A
V
-----
-
SG
MS
---
-
-----
-
---
V
Y
A
Q
A
A
V
E
P
KE-
D
T
IT
VTA
-
A
P
---
AP
Q
E
SAW
G
-
-
P
A
A
T
IAA
KH
SAT
A
TK
TDT
P
IE
K
T
PQS
IS
VV
T
N
E
E
I
Q
M
H
Q
FQ
SV
K
E
A
L
G
Y
TPGV
---
T
V
S
S
R
GAS
N
T
Y
D
FVI
I
RGF
-
SSV
G
L
NQ
N
NY
L
--
-
DG
L
K
-
LQGNF
Y
N
--
DA
VI
D
P
-
YM
L
ERVE
LM
RGP
T
S
V
L
YG
KS
NPGG
I
I
S
MV
S
KR
P
T
TEP
LKE
I
-----
Q
--
FK
M
------
G
T
D
N
L
FQ
T
GF
D
F
S
DA
L
DD
N
G
EFS
Y
R
LT
G
LA
R
S
T
N
E
Q
QKNSE
S
Q
R
Y
T
IAP
S
--
FS
W
RP
D
-
D
K
T
NF
T
F
LS
Y
-
FQN
E
------
P
E
T
G
YYGW
-
LP
KE
GT
V
-----
-E
P
L
--
PN
GK
--
RL
P
TDF
N
E
G
AS
N
NTYSRN
Q
K
M
V
GY
S
F
E
H
G
F
N
DT
FTVR
Q
N
LR
F
SE
M
K
--
-----
-
T
SQ
-------------------
KS
V
Y
GTG
IA
S
D
-------------------------
GH
T
L
N
R
-
--
GT
------
VV
D
NE
R
L
QNF
S
V
D
TQ
L
E
S
KF
AT
GEV
E
H
T
L
LT
G
V
----------
D
F
MR
MR
N
------------
D
I
NAS
F
G
--
-
S
A
P
SI
D
-
L
--
Y
N
K
-------------
YHPE
Y
F
A
FG-----NAEPYQ-
M
N
E
SK
Q
T
-
-
-
G
I
Y
VQ
D
QAE
W
-
N
KWVFT
LG
G
R
-------
Y
DWSK
Q
-
ATTV
R
--------------
ENSYTP
TEGYI
ER
N
D
H
QF
----
T
W
RG
G
VNY
L
F
D
N
G
I
S
P
Y
F
SY
S
Q
SF
E
P
---------
S
AF
DL
W
SN
P
RV
SY
K
P
S
K
G
E
Q
YE
-------
A
G
V
K
YVPN
D
MP
V
V
V
T
G
A
V
Y
Q
L
T
K
T
N
NL
T
A
DP
-
T
NP
L
A
QVPA
GE
I
R
--------
AR
GVE
L
E
AK
---
A
AL
N
A
N
I
N
L
TA
SYTY
T
DAE
YT
--
K
DT
NL
K
G
-
K
TP
E
QV
P
-----
E
HMASLW
G
D
Y
T
F
N
E
G
P
L
SG
-
LT
L
G
-----
T
G
G
R
F
IG
--
S
S
Y
---
GD
P
A
N
-
TF
K
V
--
GS
A
A
V
M
D
A
V
V
K
Y
D
LAR
F
GMA
GS
SL
A
V
NVNNL
L
D
RE
Y
V
AS
CF
--
Q
T
YG
CF
W
GA
E
R
Q
V
VA
T
A
T
F
R
F
fig|574521.7.peg.165
Escherichia coli O127:H6 str. E2348/69 (16-731/731)
IAV
V
V
A
T
A
V
-----
-
SG
MS
---
-
-----
-
---
V
Y
A
Q
A
A
V
E
P
KE-
D
T
IT
VTA
-
A
P
---
AP
Q
E
SAW
G
-
-
P
A
A
T
IAA
KH
SAT
A
TK
TDT
P
IE
K
T
PQS
IS
VV
T
R
E
E
M
D
I
K
Q
PA
T
V
K
E
A
L
D
Y
TP
S
V
---
-
F
S
T
R
G
S
S
T
T
Y
D
VVS
I
RGF
TT
A
STV
NT
N
Q
Y
L
--
-
DG
L
K
-
LQGDN
YS
--
E
A
SI
D
P
-
Y
F
L
ERVE
LL
RGP
V
S
V
L
YG
KS
H
PGG
V
VS
MV
S
KR
P
S
TDP
I
KE
I
-----
Q
--
FK
M
------
G
T
D
N
L
WQ
T
GF
D
F
S
DA
I
DD
DG
VWS
Y
R
LT
G
LG
R
S
Q
D
A
Q
QKYAK
T
T
R
YA
V
AP
S
--
FS
W
RP
D
-
D
K
T
DF
T
F
LS
N
-
FQS
D
------
P
D
A
G
YYGW
-
LP
RQ
GT
V
-----
-V
P
Y
QDA
N
GS
WH
KL
P
TDF
N
E
G
EK
DN
KM
SR
RQQ
L
I
GY
S
F
A
H
E
F
N
DT
FTVR
Q
N
LR
YT
R
I
H
--
-----
-
T
L
Y
-------------------
DA
V
Y
G
N
G
YI
A
P
A
--------------------------
Q
I
S
R
-
--
A
Y
------
VR
S
DE
D
L
NSF
T
V
D
TQ
L
QS
NF
A
I
GAV
A
H
T
L
LT
G
V
----------
D
Y
L
R
MR
N
------------
D
I
DAN
YG
TA
NP
I
S
MT
D
P
Q
--
Y
GN
-------------
ANIN
-
IN
F---------PYAV
I
N
R
Q
E
Q
T
-
-
-
G
L
Y
I
Q
D
QSE
W
-
N
KWVLT
LG
G
R
-------
Y
DFAK
T
-
STYT
R
--------------
STSSLD
-----
EI
N
D
Q
QF
----
T
W
RG
G
I
NY
L
F
D
N
G
I
S
P
Y
F
SY
S
E
SF
E
P
---------
V
S
-
GA
T
KE
G
KP
-
F
D
P
S
R
G
KQ
YE
-------
A
G
V
K
YVPK
D
TP
V
T
V
T
A
SV
F
Q
L
T
K
D
K
NL
T
A
DP
-
S
N
T
L
F
SVQG
GE
I
R
--------
S
R
G
F
E
I
E
AK
---
A
A
V
N
A
N
I
N
V
TA
A
Y
S
Y
T
DAE
YT
--
K
DT
L
Y
K
G
-
K
RP
A
E
V
P
-----
R
N
MASLW
A
D
Y
T
F
H
ETA
L
SG
-
L
S
L
G
-----
A
G
A
R
Y
FG
D
T
S
S
F
YT
T
GD
KT
N
Q
TF
N
V
--
G
G
Y
T
LVD
A
MI
K
Y
D
LAR
F
GM
P
GS
S
V
GV
NVNNLFD
RE
Y
V
S
S
CY
--
RD
Y
A
CY
W
GA
E
R
Q
V
VA
T
A
T
F
R
F
fig|413997.3.peg.159
Escherichia coli B str. REL606 (16-747/747)
IAV
V
V
A
T
A
V
-----
-
SG
MS
---
-
-----
-
---
V
Y
A
Q
A
A
V
E
P
KE-
D
T
IT
VTA
-
A
P
---
AP
Q
E
SAW
G
-
-
P
A
A
T
IAARQSAT
GTK
TDT
P
IQ
KV
PQS
IS
VV
T
A
E
E
M
A
L
H
Q
PK
SV
K
E
A
L
S
Y
TPGV
---
S
V
G
T
R
GAS
N
T
Y
D
HLI
I
RGF
-
AAEGQ
SQ
N
NY
L
--
-
N
G
L
K
-
LQGNF
Y
N
--
DA
AI
D
P
-
YM
L
ER
A
E
I
M
RGP
V
S
V
L
YG
KS
S
PGG
LL
NMV
S
KR
P
T
TEP
LKEV
-----
Q
--
FK
A
------
G
T
D
SL
FQ
T
GF
D
F
S
DA
L
DD
DG
VYS
Y
R
LT
G
LA
R
S
A
N
A
Q
QKGSE
E
Q
R
YAIAPA
--
F
TW
RP
D
-
D
K
T
NF
T
F
LS
Y
-
FQN
E
------
P
E
T
G
YYGW
-
LP
KE
GT
V
-----
-E
P
L
--
PN
GK
--
RL
P
TDF
N
E
G
AK
N
NTYSRNEK
M
V
GY
S
F
D
H
E
F
N
DT
FTVR
Q
N
LR
F
A
E
N
K
--
-----
-
T
SQ
-------------------
NS
V
Y
G
Y
G
VC
S
D
PANAYSKQ
--------
CAALAPADKGH
Y
L
A
R
-
--
KY
------
VV
D
DE
K
L
QNF
S
V
D
TQ
L
QS
KF
AT
GDI
D
H
T
L
LT
G
V
----------
D
F
MR
MR
N
------------
D
I
NAW
F
G
YD
DS
V
P
LL
N
-
L
--
Y
N
P
-------------
VNTD
-
FD
FNAKDPANSGPYRI
L
N
KQ
K
Q
T
-
-
-
G
V
Y
VQ
D
QAQ
W
-
D
KVLVT
LG
G
R
-------
Y
DWAD
Q
-
ESLN
R
--------------
VAGTTD
-----
KR
DD
K
QF
----
T
W
RG
G
VNY
L
F
D
N
GVT
P
Y
F
SY
S
E
SF
E
P
---------
S
S
-
QV
G
KD
G
NI
-
F
A
P
S
K
G
KQ
YE
-------
V
G
V
K
YVPE
D
RP
IV
V
T
G
A
V
Y
N
L
T
K
T
N
NL
M
A
DP
-
E
G
S
F
F
SVEG
GE
I
R
--------
AR
GVE
I
E
AK
---
A
AL
S
A
SVN
V
VG
SYTY
T
DAE
YT
--
TDTTY
K
G
-
N
TP
AQV
P
-----
KHMASLW
A
D
Y
T
F
F
DG
P
L
SG
-
LT
L
G
-----
T
G
G
R
Y
TG
--
S
S
Y
---
GD
P
A
N
-
S
F
K
V
--
GSY
T
V
VD
ALV
RY
D
LARVGMA
GS
N
VALH
VNNLFD
RE
Y
V
AS
CF
--
NT
YG
CF
W
GA
E
R
Q
V
VA
T
A
T
F
R
F
fig|656437.3.peg.218
Escherichia coli TA143 (16-747/747)
IAV
V
V
A
T
A
V
-----
-
SG
MS
---
-
-----
-
---
V
Y
A
Q
A
A
V
E
P
KE-
D
T
IT
VTA
-
A
P
---
AP
Q
E
SAW
G
-
-
P
A
A
T
IAARQSAT
GTK
TDT
P
IQ
KV
PQS
IS
VV
T
A
E
E
M
A
L
H
Q
PK
SV
K
E
A
L
S
Y
TPGV
---
S
V
G
T
R
GAS
N
T
Y
D
HLI
I
RGF
-
AAEGQ
SQ
N
NY
L
--
-
N
G
L
K
-
LQGNF
Y
N
--
DA
VI
D
P
-
YM
L
ER
A
E
I
M
RGP
V
S
V
L
YG
KS
S
PGG
LL
NMV
S
KR
P
T
TEP
LKEV
-----
Q
--
FK
A
------
G
T
D
SL
FQ
T
GF
D
F
S
DA
L
DD
DG
VYS
Y
R
LT
G
LA
R
S
A
N
A
Q
QKGSE
E
Q
R
YAIAPA
--
F
TW
RP
D
-
D
K
T
NF
T
F
LS
Y
-
FQN
E
------
P
E
T
G
YYGW
-
LP
KE
GT
V
-----
-E
P
L
--
PN
GK
--
RL
P
TDF
N
E
G
AK
N
NTYSRNEK
M
V
GY
S
F
D
H
E
F
N
DT
FTVR
Q
N
LR
F
A
E
N
K
--
-----
-
T
SQ
-------------------
NS
V
Y
G
Y
G
VC
S
D
PANAYSKQ
--------
CAALAPADKGH
Y
L
A
R
-
--
KY
------
VV
D
DE
K
L
QNF
S
V
D
TQ
L
QS
KF
AT
GDI
D
H
T
L
LT
G
V
----------
D
F
MR
MR
N
------------
D
I
NAW
F
G
YD
DS
V
P
LL
D
-
L
--
Y
N
P
-------------
VNTD
-
FD
FNAKDPDNSGPYRI
L
N
KQ
K
Q
T
-
-
-
G
V
Y
VQ
D
QAQ
W
-
D
KVLVT
LG
G
R
-------
Y
DWAD
Q
-
ESLN
R
--------------
VAGTTD
-----
KR
DD
K
QF
----
T
W
RG
G
VNY
L
F
D
N
GVT
P
Y
F
SY
S
E
SF
E
P
---------
S
S
-
QV
G
KD
G
NI
-
F
A
P
S
K
G
KQ
YE
-------
V
G
V
K
YVPE
D
RP
IV
V
T
G
A
V
Y
N
L
T
K
T
N
NL
M
A
DP
-
E
G
S
F
F
SVEG
GE
I
R
--------
AR
GVE
I
E
AK
---
A
AL
S
A
SVN
V
VG
SYTY
T
DAE
YT
--
TDTTY
K
G
-
N
TP
AQV
P
-----
KHMASLW
A
D
Y
T
F
F
DG
P
L
SG
-
LT
L
G
-----
T
G
G
R
Y
TG
--
S
S
Y
---
GD
P
T
N
-
S
F
K
V
--
GSY
T
V
VD
ALV
RY
D
LARVGMA
GS
N
VALH
VNNLFD
RE
Y
V
AS
CF
--
NT
YG
CF
W
GA
E
R
Q
V
VA
T
A
T
F
R
F
fig|362663.8.peg.163
Escherichia coli 536 (16-747/747)
IAV
V
V
A
T
A
V
-----
-
SG
MS
---
-
-----
-
---
V
Y
A
Q
A
A
V
E
P
KE-
D
T
IT
VTA
-
A
P
---
AP
Q
E
SAW
G
-
-
P
A
A
T
IAARQSAT
GTK
TDT
P
IQ
KV
PQS
IS
VV
T
A
E
E
M
A
L
H
Q
PK
SV
K
E
A
L
S
Y
TPGV
---
S
V
G
T
R
GAS
N
T
Y
D
HLI
I
RGF
-
AAEGQ
SQ
N
NY
L
--
-
N
G
L
K
-
LQGNF
Y
N
--
DA
VI
D
P
-
YM
L
ER
A
E
I
M
RGP
V
S
V
L
YG
KS
S
PGG
LL
NMV
S
KR
P
T
TEP
LKEV
-----
Q
--
FK
A
------
G
T
D
SL
FQ
T
GF
D
F
S
DA
L
DD
DG
VYS
Y
R
LT
G
LA
R
S
A
N
A
Q
QKGSE
E
Q
R
YAIAPA
--
F
TW
RP
D
-
D
K
T
NF
T
F
LS
Y
-
FQN
E
------
P
E
T
G
YYGW
-
LP
KE
GT
V
-----
-E
P
L
--
PN
GK
--
RL
P
TDF
N
E
G
AK
N
NTYSRNEK
M
V
GY
S
F
D
H
E
F
N
DT
FTVR
Q
N
LR
F
A
E
N
K
--
-----
-
T
SQ
-------------------
NS
V
Y
G
Y
G
VC
S
D
PANAYSKQ
--------
CAALAPADKGH
Y
L
A
R
-
--
KY
------
VV
D
DE
K
L
QNF
S
V
D
TQ
L
QS
KF
AT
GDI
D
H
T
L
LT
G
V
----------
D
F
MR
MR
N
------------
D
I
NAW
F
G
YD
DS
V
P
LL
D
-
L
--
Y
N
P
-------------
VNTD
-
FD
FNAKDPDNSGPYRI
L
N
KQ
K
Q
T
-
-
-
G
V
Y
VQ
D
QAQ
W
-
D
KVLVT
LG
G
R
-------
Y
DWAD
Q
-
ESLN
R
--------------
VAGTTD
-----
KR
DD
K
QF
----
T
W
RG
G
VNY
L
F
D
N
GVT
P
Y
F
SY
S
E
SF
E
P
---------
S
S
-
QV
G
KD
G
NI
-
F
A
P
S
K
G
KQ
YE
-------
V
G
V
K
YVPE
D
RP
IV
V
T
G
A
V
Y
N
L
T
K
T
N
NL
M
A
DP
-
E
G
S
F
F
SVEG
GE
I
R
--------
AR
GVE
I
E
AK
---
A
AL
S
A
SVN
V
VG
SYTY
T
DAE
YT
--
TDTTY
K
G
-
N
TP
AQV
P
-----
KHMASLW
A
D
Y
T
F
F
DG
P
L
SG
-
LT
L
G
-----
T
G
G
R
Y
TG
--
S
S
Y
---
GD
P
A
N
-
S
F
K
V
--
GSY
T
V
VD
ALV
RY
D
LARVGMA
GS
N
VALH
VNNLFD
RE
Y
V
AS
CF
--
NT
YG
CF
W
GA
E
R
Q
V
VA
T
A
T
F
R
F
fig|362663.9.peg.163
Escherichia coli 536 (16-747/747)
IAV
V
V
A
T
A
V
-----
-
SG
MS
---
-
-----
-
---
V
Y
A
Q
A
A
V
E
P
KE-
D
T
IT
VTA
-
A
P
---
AP
Q
E
SAW
G
-
-
P
A
A
T
IAARQSAT
GTK
TDT
P
IQ
KV
PQS
IS
VV
T
A
E
E
M
A
L
H
Q
PK
SV
K
E
A
L
S
Y
TPGV
---
S
V
G
T
R
GAS
N
T
Y
D
HLI
I
RGF
-
AAEGQ
SQ
N
NY
L
--
-
N
G
L
K
-
LQGNF
Y
N
--
DA
VI
D
P
-
YM
L
ER
A
E
I
M
RGP
V
S
V
L
YG
KS
S
PGG
LL
NMV
S
KR
P
T
TEP
LKEV
-----
Q
--
FK
A
------
G
T
D
SL
FQ
T
GF
D
F
S
DA
L
DD
DG
VYS
Y
R
LT
G
LA
R
S
A
N
A
Q
QKGSE
E
Q
R
YAIAPA
--
F
TW
RP
D
-
D
K
T
NF
T
F
LS
Y
-
FQN
E
------
P
E
T
G
YYGW
-
LP
KE
GT
V
-----
-E
P
L
--
PN
GK
--
RL
P
TDF
N
E
G
AK
N
NTYSRNEK
M
V
GY
S
F
D
H
E
F
N
DT
FTVR
Q
N
LR
F
A
E
N
K
--
-----
-
T
SQ
-------------------
NS
V
Y
G
Y
G
VC
S
D
PANAYSKQ
--------
CAALAPADKGH
Y
L
A
R
-
--
KY
------
VV
D
DE
K
L
QNF
S
V
D
TQ
L
QS
KF
AT
GDI
D
H
T
L
LT
G
V
----------
D
F
MR
MR
N
------------
D
I
NAW
F
G
YD
DS
V
P
LL
D
-
L
--
Y
N
P
-------------
VNTD
-
FD
FNAKDPDNSGPYRI
L
N
KQ
K
Q
T
-
-
-
G
V
Y
VQ
D
QAQ
W
-
D
KVLVT
LG
G
R
-------
Y
DWAD
Q
-
ESLN
R
--------------
VAGTTD
-----
KR
DD
K
QF
----
T
W
RG
G
VNY
L
F
D
N
GVT
P
Y
F
SY
S
E
SF
E
P
---------
S
S
-
QV
G
KD
G
NI
-
F
A
P
S
K
G
KQ
YE
-------
V
G
V
K
YVPE
D
RP
IV
V
T
G
A
V
Y
N
L
T
K
T
N
NL
M
A
DP
-
E
G
S
F
F
SVEG
GE
I
R
--------
AR
GVE
I
E
AK
---
A
AL
S
A
SVN
V
VG
SYTY
T
DAE
YT
--
TDTTY
K
G
-
N
TP
AQV
P
-----
KHMASLW
A
D
Y
T
F
F
DG
P
L
SG
-
LT
L
G
-----
T
G
G
R
Y
TG
--
S
S
Y
---
GD
P
A
N
-
S
F
K
V
--
GSY
T
V
VD
ALV
RY
D
LARVGMA
GS
N
VALH
VNNLFD
RE
Y
V
AS
CF
--
NT
YG
CF
W
GA
E
R
Q
V
VA
T
A
T
F
R
F
fig|405955.13.peg.163
Escherichia coli APEC O1 (16-747/747)
IAV
V
V
A
T
A
V
-----
-
SG
MS
---
-
-----
-
---
V
Y
A
Q
A
A
V
E
P
KE-
D
T
IT
VTA
-
A
P
---
AP
Q
E
SAW
G
-
-
P
A
A
T
IAARQSAT
GTK
TDT
P
IQ
KV
PQS
IS
VV
T
A
E
E
M
A
L
H
Q
PK
SV
K
E
A
L
S
Y
TPGV
---
S
V
G
T
R
GAS
N
T
Y
D
HLI
I
RGF
-
AAEGQ
SQ
N
NY
L
--
-
N
G
L
K
-
LQGNF
Y
N
--
DA
VI
D
P
-
YM
L
ER
A
E
I
M
RGP
V
S
V
L
YG
KS
S
PGG
LL
NMV
S
KR
P
T
TEP
LKEV
-----
Q
--
FK
A
------
G
T
D
SL
FQ
T
GF
D
F
S
DA
L
DD
DG
VYS
Y
R
LT
G
LA
R
S
A
N
A
Q
QKGSE
E
Q
R
YAIAPA
--
F
TW
RP
D
-
D
K
T
NF
T
F
LS
Y
-
FQN
E
------
P
E
T
G
YYGW
-
LP
KE
GT
V
-----
-E
P
L
--
PN
GK
--
RL
P
TDF
N
E
G
AK
N
NTYSRNEK
M
V
GY
S
F
D
H
E
F
N
DT
FTVR
Q
N
LR
F
A
E
N
K
--
-----
-
T
SQ
-------------------
NS
V
Y
G
Y
G
VC
S
D
PANAYSKQ
--------
CAALAPADKGH
Y
L
A
R
-
--
KY
------
VV
D
DE
K
L
QNF
S
V
D
TQ
L
QS
KF
AT
GDI
D
H
T
L
LT
G
V
----------
D
F
MR
MR
N
------------
D
I
NAW
F
G
YD
DS
V
P
LL
D
-
L
--
Y
N
P
-------------
VNTD
-
FD
FNAKDPDNSGPYRI
L
N
KQ
K
Q
T
-
-
-
G
V
Y
VQ
D
QAQ
W
-
D
KVLVT
LG
G
R
-------
Y
DWAD
Q
-
ESLN
R
--------------
VAGTTD
-----
KR
DD
K
QF
----
T
W
RG
G
VNY
L
F
D
N
GVT
P
Y
F
SY
S
E
SF
E
P
---------
S
S
-
QV
G
KD
G
NI
-
F
A
P
S
K
G
KQ
YE
-------
V
G
V
K
YVPE
D
RP
IV
V
T
G
A
V
Y
N
L
T
K
T
N
NL
M
A
DP
-
E
G
S
F
F
SVEG
GE
I
R
--------
AR
GVE
I
E
AK
---
A
AL
S
A
SVN
V
VG
SYTY
T
DAE
YT
--
TDTTY
K
G
-
N
TP
AQV
P
-----
KHMASLW
A
D
Y
T
F
F
DG
P
L
SG
-
LT
L
G
-----
T
G
G
R
Y
TG
--
S
S
Y
---
GD
P
A
N
-
S
F
K
V
--
GSY
T
V
VD
ALV
RY
D
LARVGMA
GS
N
VALH
VNNLFD
RE
Y
V
AS
CF
--
NT
YG
CF
W
GA
E
R
Q
V
VA
T
A
T
F
R
F
fig|405955.9.peg.131
Escherichia coli APEC O1 (16-747/747)
IAV
V
V
A
T
A
V
-----
-
SG
MS
---
-
-----
-
---
V
Y
A
Q
A
A
V
E
P
KE-
D
T
IT
VTA
-
A
P
---
AP
Q
E
SAW
G
-
-
P
A
A
T
IAARQSAT
GTK
TDT
P
IQ
KV
PQS
IS
VV
T
A
E
E
M
A
L
H
Q
PK
SV
K
E
A
L
S
Y
TPGV
---
S
V
G
T
R
GAS
N
T
Y
D
HLI
I
RGF
-
AAEGQ
SQ
N
NY
L
--
-
N
G
L
K
-
LQGNF
Y
N
--
DA
VI
D
P
-
YM
L
ER
A
E
I
M
RGP
V
S
V
L
YG
KS
S
PGG
LL
NMV
S
KR
P
T
TEP
LKEV
-----
Q
--
FK
A
------
G
T
D
SL
FQ
T
GF
D
F
S
DA
L
DD
DG
VYS
Y
R
LT
G
LA
R
S
A
N
A
Q
QKGSE
E
Q
R
YAIAPA
--
F
TW
RP
D
-
D
K
T
NF
T
F
LS
Y
-
FQN
E
------
P
E
T
G
YYGW
-
LP
KE
GT
V
-----
-E
P
L
--
PN
GK
--
RL
P
TDF
N
E
G
AK
N
NTYSRNEK
M
V
GY
S
F
D
H
E
F
N
DT
FTVR
Q
N
LR
F
A
E
N
K
--
-----
-
T
SQ
-------------------
NS
V
Y
G
Y
G
VC
S
D
PANAYSKQ
--------
CAALAPADKGH
Y
L
A
R
-
--
KY
------
VV
D
DE
K
L
QNF
S
V
D
TQ
L
QS
KF
AT
GDI
D
H
T
L
LT
G
V
----------
D
F
MR
MR
N
------------
D
I
NAW
F
G
YD
DS
V
P
LL
D
-
L
--
Y
N
P
-------------
VNTD
-
FD
FNAKDPDNSGPYRI
L
N
KQ
K
Q
T
-
-
-
G
V
Y
VQ
D
QAQ
W
-
D
KVLVT
LG
G
R
-------
Y
DWAD
Q
-
ESLN
R
--------------
VAGTTD
-----
KR
DD
K
QF
----
T
W
RG
G
VNY
L
F
D
N
GVT
P
Y
F
SY
S
E
SF
E
P
---------
S
S
-
QV
G
KD
G
NI
-
F
A
P
S
K
G
KQ
YE
-------
V
G
V
K
YVPE
D
RP
IV
V
T
G
A
V
Y
N
L
T
K
T
N
NL
M
A
DP
-
E
G
S
F
F
SVEG
GE
I
R
--------
AR
GVE
I
E
AK
---
A
AL
S
A
SVN
V
VG
SYTY
T
DAE
YT
--
TDTTY
K
G
-
N
TP
AQV
P
-----
KHMASLW
A
D
Y
T
F
F
DG
P
L
SG
-
LT
L
G
-----
T
G
G
R
Y
TG
--
S
S
Y
---
GD
P
A
N
-
S
F
K
V
--
GSY
T
V
VD
ALV
RY
D
LARVGMA
GS
N
VALH
VNNLFD
RE
Y
V
AS
CF
--
NT
YG
CF
W
GA
E
R
Q
V
VA
T
A
T
F
R
F
fig|340197.3.peg.2903
Escherichia coli F11 (16-747/747)
IAV
V
V
A
T
A
V
-----
-
SG
MS
---
-
-----
-
---
V
Y
A
Q
A
A
V
E
P
KE-
D
T
IT
VTA
-
A
P
---
AP
Q
E
SAW
G
-
-
P
A
A
T
IAARQSAT
GTK
TDT
P
IQ
KV
PQS
IS
VV
T
A
E
E
M
A
L
H
Q
PK
SV
K
E
A
L
S
Y
TPGV
---
S
V
G
T
R
GAS
N
T
Y
D
HLI
I
RGF
-
AAEGQ
SQ
N
NY
L
--
-
N
G
L
K
-
LQGNF
Y
N
--
DA
VI
D
P
-
YM
L
ER
A
E
I
M
RGP
V
S
V
L
YG
KS
S
PGG
LL
NMV
S
KR
P
T
TEP
LKEV
-----
Q
--
FK
A
------
G
T
D
SL
FQ
T
GF
D
F
S
DA
L
DD
DG
VYS
Y
R
LT
G
LA
R
S
A
N
A
Q
QKGSE
E
Q
R
YAIAPA
--
F
TW
RP
D
-
D
K
T
NF
T
F
LS
Y
-
FQN
E
------
P
E
T
G
YYGW
-
LP
KE
GT
V
-----
-E
P
L
--
PN
GK
--
RL
P
TDF
N
E
G
AK
N
NTYSRNEK
M
V
GY
S
F
D
H
E
F
N
DT
FTVR
Q
N
LR
F
A
E
N
K
--
-----
-
T
SQ
-------------------
NS
V
Y
G
Y
G
VC
S
D
PANAYSKQ
--------
CAALAPADKGH
Y
L
A
R
-
--
KY
------
VV
D
DE
K
L
QNF
S
V
D
TQ
L
QS
KF
AT
GDI
D
H
T
L
LT
G
V
----------
D
F
MR
MR
N
------------
D
I
NAW
F
G
YD
DS
V
P
LL
D
-
L
--
Y
N
P
-------------
VNTD
-
FD
FNAKDPDNSGPYRI
L
N
KQ
K
Q
T
-
-
-
G
V
Y
VQ
D
QAQ
W
-
D
KVLVT
LG
G
R
-------
Y
DWAD
Q
-
ESLN
R
--------------
VAGTTD
-----
KR
DD
K
QF
----
T
W
RG
G
VNY
L
F
D
N
GVT
P
Y
F
SY
S
E
SF
E
P
---------
S
S
-
QV
G
KD
G
NI
-
F
A
P
S
K
G
KQ
YE
-------
V
G
V
K
YVPE
D
RP
IV
V
T
G
A
V
Y
N
L
T
K
T
N
NL
M
A
DP
-
E
G
S
F
F
SVEG
GE
I
R
--------
AR
GVE
I
E
AK
---
A
AL
S
A
SVN
V
VG
SYTY
T
DAE
YT
--
TDTTY
K
G
-
N
TP
AQV
P
-----
KHMASLW
A
D
Y
T
F
F
DG
P
L
SG
-
LT
L
G
-----
T
G
G
R
Y
TG
--
S
S
Y
---
GD
P
A
N
-
S
F
K
V
--
GSY
T
V
VD
ALV
RY
D
LARVGMA
GS
N
VALH
VNNLFD
RE
Y
V
AS
CF
--
NT
YG
CF
W
GA
E
R
Q
V
VA
T
A
T
F
R
F
fig|340197.5.peg.3034
Escherichia coli F11 (16-747/747)
IAV
V
V
A
T
A
V
-----
-
SG
MS
---
-
-----
-
---
V
Y
A
Q
A
A
V
E
P
KE-
D
T
IT
VTA
-
A
P
---
AP
Q
E
SAW
G
-
-
P
A
A
T
IAARQSAT
GTK
TDT
P
IQ
KV
PQS
IS
VV
T
A
E
E
M
A
L
H
Q
PK
SV
K
E
A
L
S
Y
TPGV
---
S
V
G
T
R
GAS
N
T
Y
D
HLI
I
RGF
-
AAEGQ
SQ
N
NY
L
--
-
N
G
L
K
-
LQGNF
Y
N
--
DA
VI
D
P
-
YM
L
ER
A
E
I
M
RGP
V
S
V
L
YG
KS
S
PGG
LL
NMV
S
KR
P
T
TEP
LKEV
-----
Q
--
FK
A
------
G
T
D
SL
FQ
T
GF
D
F
S
DA
L
DD
DG
VYS
Y
R
LT
G
LA
R
S
A
N
A
Q
QKGSE
E
Q
R
YAIAPA
--
F
TW
RP
D
-
D
K
T
NF
T
F
LS
Y
-
FQN
E
------
P
E
T
G
YYGW
-
LP
KE
GT
V
-----
-E
P
L
--
PN
GK
--
RL
P
TDF
N
E
G
AK
N
NTYSRNEK
M
V
GY
S
F
D
H
E
F
N
DT
FTVR
Q
N
LR
F
A
E
N
K
--
-----
-
T
SQ
-------------------
NS
V
Y
G
Y
G
VC
S
D
PANAYSKQ
--------
CAALAPADKGH
Y
L
A
R
-
--
KY
------
VV
D
DE
K
L
QNF
S
V
D
TQ
L
QS
KF
AT
GDI
D
H
T
L
LT
G
V
----------
D
F
MR
MR
N
------------
D
I
NAW
F
G
YD
DS
V
P
LL
D
-
L
--
Y
N
P
-------------
VNTD
-
FD
FNAKDPDNSGPYRI
L
N
KQ
K
Q
T
-
-
-
G
V
Y
VQ
D
QAQ
W
-
D
KVLVT
LG
G
R
-------
Y
DWAD
Q
-
ESLN
R
--------------
VAGTTD
-----
KR
DD
K
QF
----
T
W
RG
G
VNY
L
F
D
N
GVT
P
Y
F
SY
S
E
SF
E
P
---------
S
S
-
QV
G
KD
G
NI
-
F
A
P
S
K
G
KQ
YE
-------
V
G
V
K
YVPE
D
RP
IV
V
T
G
A
V
Y
N
L
T
K
T
N
NL
M
A
DP
-
E
G
S
F
F
SVEG
GE
I
R
--------
AR
GVE
I
E
AK
---
A
AL
S
A
SVN
V
VG
SYTY
T
DAE
YT
--
TDTTY
K
G
-
N
TP
AQV
P
-----
KHMASLW
A
D
Y
T
F
F
DG
P
L
SG
-
LT
L
G
-----
T
G
G
R
Y
TG
--
S
S
Y
---
GD
P
A
N
-
S
F
K
V
--
GSY
T
V
VD
ALV
RY
D
LARVGMA
GS
N
VALH
VNNLFD
RE
Y
V
AS
CF
--
NT
YG
CF
W
GA
E
R
Q
V
VA
T
A
T
F
R
F
fig|714962.3.peg.160
Escherichia coli IHE3034 (16-747/747)
IAV
V
V
A
T
A
V
-----
-
SG
MS
---
-
-----
-
---
V
Y
A
Q
A
A
V
E
P
KE-
D
T
IT
VTA
-
A
P
---
AP
Q
E
SAW
G
-
-
P
A
A
T
IAARQSAT
GTK
TDT
P
IQ
KV
PQS
IS
VV
T
A
E
E
M
A
L
H
Q
PK
SV
K
E
A
L
S
Y
TPGV
---
S
V
G
T
R
GAS
N
T
Y
D
HLI
I
RGF
-
AAEGQ
SQ
N
NY
L
--
-
N
G
L
K
-
LQGNF
Y
N
--
DA
VI
D
P
-
YM
L
ER
A
E
I
M
RGP
V
S
V
L
YG
KS
S
PGG
LL
NMV
S
KR
P
T
TEP
LKEV
-----
Q
--
FK
A
------
G
T
D
SL
FQ
T
GF
D
F
S
DA
L
DD
DG
VYS
Y
R
LT
G
LA
R
S
A
N
A
Q
QKGSE
E
Q
R
YAIAPA
--
F
TW
RP
D
-
D
K
T
NF
T
F
LS
Y
-
FQN
E
------
P
E
T
G
YYGW
-
LP
KE
GT
V
-----
-E
P
L
--
PN
GK
--
RL
P
TDF
N
E
G
AK
N
NTYSRNEK
M
V
GY
S
F
D
H
E
F
N
DT
FTVR
Q
N
LR
F
A
E
N
K
--
-----
-
T
SQ
-------------------
NS
V
Y
G
Y
G
VC
S
D
PANAYSKQ
--------
CAALAPADKGH
Y
L
A
R
-
--
KY
------
VV
D
DE
K
L
QNF
S
V
D
TQ
L
QS
KF
AT
GDI
D
H
T
L
LT
G
V
----------
D
F
MR
MR
N
------------
D
I
NAW
F
G
YD
DS
V
P
LL
D
-
L
--
Y
N
P
-------------
VNTD
-
FD
FNAKDPDNSGPYRI
L
N
KQ
K
Q
T
-
-
-
G
V
Y
VQ
D
QAQ
W
-
D
KVLVT
LG
G
R
-------
Y
DWAD
Q
-
ESLN
R
--------------
VAGTTD
-----
KR
DD
K
QF
----
T
W
RG
G
VNY
L
F
D
N
GVT
P
Y
F
SY
S
E
SF
E
P
---------
S
S
-
QV
G
KD
G
NI
-
F
A
P
S
K
G
KQ
YE
-------
V
G
V
K
YVPE
D
RP
IV
V
T
G
A
V
Y
N
L
T
K
T
N
NL
M
A
DP
-
E
G
S
F
F
SVEG
GE
I
R
--------
AR
GVE
I
E
AK
---
A
AL
S
A
SVN
V
VG
SYTY
T
DAE
YT
--
TDTTY
K
G
-
N
TP
AQV
P
-----
KHMASLW
A
D
Y
T
F
F
DG
P
L
SG
-
LT
L
G
-----
T
G
G
R
Y
TG
--
S
S
Y
---
GD
P
A
N
-
S
F
K
V
--
GSY
T
V
VD
ALV
RY
D
LARVGMA
GS
N
VALH
VNNLFD
RE
Y
V
AS
CF
--
NT
YG
CF
W
GA
E
R
Q
V
VA
T
A
T
F
R
F
fig|749550.3.peg.2479
Escherichia coli MS 200-1 (16-747/747)
IAV
V
V
A
T
A
V
-----
-
SG
MS
---
-
-----
-
---
V
Y
A
Q
A
A
V
E
P
KE-
D
T
IT
VTA
-
A
P
---
AP
Q
E
SAW
G
-
-
P
A
A
T
IAARQSAT
GTK
TDT
P
IQ
KV
PQS
IS
VV
T
A
E
E
M
A
L
H
Q
PK
SV
K
E
A
L
S
Y
TPGV
---
S
V
G
T
R
GAS
N
T
Y
D
HLI
I
RGF
-
AAEGQ
SQ
N
NY
L
--
-
N
G
L
K
-
LQGNF
Y
N
--
DA
VI
D
P
-
YM
L
ER
A
E
I
M
RGP
V
S
V
L
YG
KS
S
PGG
LL
NMV
S
KR
P
T
TEP
LKEV
-----
Q
--
FK
A
------
G
T
D
SL
FQ
T
GF
D
F
S
DA
L
DD
DG
VYS
Y
R
LT
G
LA
R
S
A
N
A
Q
QKGSE
E
Q
R
YAIAPA
--
F
TW
RP
D
-
D
K
T
NF
T
F
LS
Y
-
FQN
E
------
P
E
T
G
YYGW
-
LP
KE
GT
V
-----
-E
P
L
--
PN
GK
--
RL
P
TDF
N
E
G
AK
N
NTYSRNEK
M
V
GY
S
F
D
H
E
F
N
DT
FTVR
Q
N
LR
F
A
E
N
K
--
-----
-
T
SQ
-------------------
NS
V
Y
G
Y
G
VC
S
D
PANAYSKQ
--------
CAALAPADKGH
Y
L
A
R
-
--
KY
------
VV
D
DE
K
L
QNF
S
V
D
TQ
L
QS
KF
AT
GDI
D
H
T
L
LT
G
V
----------
D
F
MR
MR
N
------------
D
I
NAW
F
G
YD
DS
V
P
LL
D
-
L
--
Y
N
P
-------------
VNTD
-
FD
FNAKDPDNSGPYRI
L
N
KQ
K
Q
T
-
-
-
G
V
Y
VQ
D
QAQ
W
-
D
KVLVT
LG
G
R
-------
Y
DWAD
Q
-
ESLN
R
--------------
VAGTTD
-----
KR
DD
K
QF
----
T
W
RG
G
VNY
L
F
D
N
GVT
P
Y
F
SY
S
E
SF
E
P
---------
S
S
-
QV
G
KD
G
NI
-
F
A
P
S
K
G
KQ
YE
-------
V
G
V
K
YVPE
D
RP
IV
V
T
G
A
V
Y
N
L
T
K
T
N
NL
M
A
DP
-
E
G
S
F
F
SVEG
GE
I
R
--------
AR
GVE
I
E
AK
---
A
AL
S
A
SVN
V
VG
SYTY
T
DAE
YT
--
TDTTY
K
G
-
N
TP
AQV
P
-----
KHMASLW
A
D
Y
T
F
F
DG
P
L
SG
-
LT
L
G
-----
T
G
G
R
Y
TG
--
S
S
Y
---
GD
P
A
N
-
S
F
K
V
--
GSY
T
V
VD
ALV
RY
D
LARVGMA
GS
N
VALH
VNNLFD
RE
Y
V
AS
CF
--
NT
YG
CF
W
GA
E
R
Q
V
VA
T
A
T
F
R
F
fig|749531.3.peg.4461
Escherichia coli MS 69-1 (16-747/747)
IAV
V
V
A
T
A
V
-----
-
SG
MS
---
-
-----
-
---
V
Y
A
Q
A
A
V
E
P
KE-
D
T
IT
VTA
-
A
P
---
AP
Q
E
SAW
G
-
-
P
A
A
T
IAARQSAT
GTK
TDT
P
IQ
KV
PQS
IS
VV
T
A
E
E
M
A
L
H
Q
PK
SV
K
E
A
L
S
Y
TPGV
---
S
V
G
T
R
GAS
N
T
Y
D
HLI
I
RGF
-
AAEGQ
SQ
N
NY
L
--
-
N
G
L
K
-
LQGNF
Y
N
--
DA
VI
D
P
-
YM
L
ER
A
E
I
M
RGP
V
S
V
L
YG
KS
S
PGG
LL
NMV
S
KR
P
T
TEP
LKEV
-----
Q
--
FK
A
------
G
T
D
SL
FQ
T
GF
D
F
S
DA
L
DD
DG
VYS
Y
R
LT
G
LA
R
S
A
N
A
Q
QKGSE
E
Q
R
YAIAPA
--
F
TW
RP
D
-
D
K
T
NF
T
F
LS
Y
-
FQN
E
------
P
E
T
G
YYGW
-
LP
KE
GT
V
-----
-E
P
L
--
PN
GK
--
RL
P
TDF
N
E
G
AK
N
NTYSRNEK
M
V
GY
S
F
D
H
E
F
N
DT
FTVR
Q
N
LR
F
A
E
N
K
--
-----
-
T
SQ
-------------------
NS
V
Y
G
Y
G
VC
S
D
PANAYSKQ
--------
CAALAPADKGH
Y
L
A
R
-
--
KY
------
VV
D
DE
K
L
QNF
S
V
D
TQ
L
QS
KF
AT
GDI
D
H
T
L
LT
G
V
----------
D
F
MR
MR
N
------------
D
I
NAW
F
G
YD
DS
V
P
LL
D
-
L
--
Y
N
P
-------------
VNTD
-
FD
FNAKDPDNSGPYRI
L
N
KQ
K
Q
T
-
-
-
G
V
Y
VQ
D
QAQ
W
-
D
KVLVT
LG
G
R
-------
Y
DWAD
Q
-
ESLN
R
--------------
VAGTTD
-----
KR
DD
K
QF
----
T
W
RG
G
VNY
L
F
D
N
GVT
P
Y
F
SY
S
E
SF
E
P
---------
S
S
-
QV
G
KD
G
NI
-
F
A
P
S
K
G
KQ
YE
-------
V
G
V
K
YVPE
D
RP
IV
V
T
G
A
V
Y
N
L
T
K
T
N
NL
M
A
DP
-
E
G
S
F
F
SVEG
GE
I
R
--------
AR
GVE
I
E
AK
---
A
AL
S
A
SVN
V
VG
SYTY
T
DAE
YT
--
TDTTY
K
G
-
N
TP
AQV
P
-----
KHMASLW
A
D
Y
T
F
F
DG
P
L
SG
-
LT
L
G
-----
T
G
G
R
Y
TG
--
S
S
Y
---
GD
P
A
N
-
S
F
K
V
--
GSY
T
V
VD
ALV
RY
D
LARVGMA
GS
N
VALH
VNNLFD
RE
Y
V
AS
CF
--
NT
YG
CF
W
GA
E
R
Q
V
VA
T
A
T
F
R
F
fig|685038.3.peg.157
Escherichia coli O83:H1 str. NRG 857C (16-747/747)
IAV
V
V
A
T
A
V
-----
-
SG
MS
---
-
-----
-
---
V
Y
A
Q
A
A
V
E
P
KE-
D
T
IT
VTA
-
A
P
---
AP
Q
E
SAW
G
-
-
P
A
A
T
IAARQSAT
GTK
TDT
P
IQ
KV
PQS
IS
VV
T
A
E
E
M
A
L
H
Q
PK
SV
K
E
A
L
S
Y
TPGV
---
S
V
G
T
R
GAS
N
T
Y
D
HLI
I
RGF
-
AAEGQ
SQ
N
NY
L
--
-
N
G
L
K
-
LQGNF
Y
N
--
DA
VI
D
P
-
YM
L
ER
A
E
I
M
RGP
V
S
V
L
YG
KS
S
PGG
LL
NMV
S
KR
P
T
TEP
LKEV
-----
Q
--
FK
A
------
G
T
D
SL
FQ
T
GF
D
F
S
DA
L
DD
DG
VYS
Y
R
LT
G
LA
R
S
A
N
A
Q
QKGSE
E
Q
R
YAIAPA
--
F
TW
RP
D
-
D
K
T
NF
T
F
LS
Y
-
FQN
E
------
P
E
T
G
YYGW
-
LP
KE
GT
V
-----
-E
P
L
--
PN
GK
--
RL
P
TDF
N
E
G
AK
N
NTYSRNEK
M
V
GY
S
F
D
H
E
F
N
DT
FTVR
Q
N
LR
F
A
E
N
K
--
-----
-
T
SQ
-------------------
NS
V
Y
G
Y
G
VC
S
D
PANAYSKQ
--------
CAALAPADKGH
Y
L
A
R
-
--
KY
------
VV
D
DE
K
L
QNF
S
V
D
TQ
L
QS
KF
AT
GDI
D
H
T
L
LT
G
V
----------
D
F
MR
MR
N
------------
D
I
NAW
F
G
YD
DS
V
P
LL
D
-
L
--
Y
N
P
-------------
VNTD
-
FD
FNAKDPDNSGPYRI
L
N
KQ
K
Q
T
-
-
-
G
V
Y
VQ
D
QAQ
W
-
D
KVLVT
LG
G
R
-------
Y
DWAD
Q
-
ESLN
R
--------------
VAGTTD
-----
KR
DD
K
QF
----
T
W
RG
G
VNY
L
F
D
N
GVT
P
Y
F
SY
S
E
SF
E
P
---------
S
S
-
QV
G
KD
G
NI
-
F
A
P
S
K
G
KQ
YE
-------
V
G
V
K
YVPE
D
RP
IV
V
T
G
A
V
Y
N
L
T
K
T
N
NL
M
A
DP
-
E
G
S
F
F
SVEG
GE
I
R
--------
AR
GVE
I
E
AK
---
A
AL
S
A
SVN
V
VG
SYTY
T
DAE
YT
--
TDTTY
K
G
-
N
TP
AQV
P
-----
KHMASLW
A
D
Y
T
F
F
DG
P
L
SG
-
LT
L
G
-----
T
G
G
R
Y
TG
--
S
S
Y
---
GD
P
A
N
-
S
F
K
V
--
GSY
T
V
VD
ALV
RY
D
LARVGMA
GS
N
VALH
VNNLFD
RE
Y
V
AS
CF
--
NT
YG
CF
W
GA
E
R
Q
V
VA
T
A
T
F
R
F
fig|585035.6.peg.164
Escherichia coli S88 (16-747/747)
IAV
V
V
A
T
A
V
-----
-
SG
MS
---
-
-----
-
---
V
Y
A
Q
A
A
V
E
P
KE-
D
T
IT
VTA
-
A
P
---
AP
Q
E
SAW
G
-
-
P
A
A
T
IAARQSAT
GTK
TDT
P
IQ
KV
PQS
IS
VV
T
A
E
E
M
A
L
H
Q
PK
SV
K
E
A
L
S
Y
TPGV
---
S
V
G
T
R
GAS
N
T
Y
D
HLI
I
RGF
-
AAEGQ
SQ
N
NY
L
--
-
N
G
L
K
-
LQGNF
Y
N
--
DA
VI
D
P
-
YM
L
ER
A
E
I
M
RGP
V
S
V
L
YG
KS
S
PGG
LL
NMV
S
KR
P
T
TEP
LKEV
-----
Q
--
FK
A
------
G
T
D
SL
FQ
T
GF
D
F
S
DA
L
DD
DG
VYS
Y
R
LT
G
LA
R
S
A
N
A
Q
QKGSE
E
Q
R
YAIAPA
--
F
TW
RP
D
-
D
K
T
NF
T
F
LS
Y
-
FQN
E
------
P
E
T
G
YYGW
-
LP
KE
GT
V
-----
-E
P
L
--
PN
GK
--
RL
P
TDF
N
E
G
AK
N
NTYSRNEK
M
V
GY
S
F
D
H
E
F
N
DT
FTVR
Q
N
LR
F
A
E
N
K
--
-----
-
T
SQ
-------------------
NS
V
Y
G
Y
G
VC
S
D
PANAYSKQ
--------
CAALAPADKGH
Y
L
A
R
-
--
KY
------
VV
D
DE
K
L
QNF
S
V
D
TQ
L
QS
KF
AT
GDI
D
H
T
L
LT
G
V
----------
D
F
MR
MR
N
------------
D
I
NAW
F
G
YD
DS
V
P
LL
D
-
L
--
Y
N
P
-------------
VNTD
-
FD
FNAKDPDNSGPYRI
L
N
KQ
K
Q
T
-
-
-
G
V
Y
VQ
D
QAQ
W
-
D
KVLVT
LG
G
R
-------
Y
DWAD
Q
-
ESLN
R
--------------
VAGTTD
-----
KR
DD
K
QF
----
T
W
RG
G
VNY
L
F
D
N
GVT
P
Y
F
SY
S
E
SF
E
P
---------
S
S
-
QV
G
KD
G
NI
-
F
A
P
S
K
G
KQ
YE
-------
V
G
V
K
YVPE
D
RP
IV
V
T
G
A
V
Y
N
L
T
K
T
N
NL
M
A
DP
-
E
G
S
F
F
SVEG
GE
I
R
--------
AR
GVE
I
E
AK
---
A
AL
S
A
SVN
V
VG
SYTY
T
DAE
YT
--
TDTTY
K
G
-
N
TP
AQV
P
-----
KHMASLW
A
D
Y
T
F
F
DG
P
L
SG
-
LT
L
G
-----
T
G
G
R
Y
TG
--
S
S
Y
---
GD
P
A
N
-
S
F
K
V
--
GSY
T
V
VD
ALV
RY
D
LARVGMA
GS
N
VALH
VNNLFD
RE
Y
V
AS
CF
--
NT
YG
CF
W
GA
E
R
Q
V
VA
T
A
T
F
R
F
fig|869729.3.peg.5068
Escherichia coli UM146 (16-747/747)
IAV
V
V
A
T
A
V
-----
-
SG
MS
---
-
-----
-
---
V
Y
A
Q
A
A
V
E
P
KE-
D
T
IT
VTA
-
A
P
---
AP
Q
E
SAW
G
-
-
P
A
A
T
IAARQSAT
GTK
TDT
P
IQ
KV
PQS
IS
VV
T
A
E
E
M
A
L
H
Q
PK
SV
K
E
A
L
S
Y
TPGV
---
S
V
G
T
R
GAS
N
T
Y
D
HLI
I
RGF
-
AAEGQ
SQ
N
NY
L
--
-
N
G
L
K
-
LQGNF
Y
N
--
DA
VI
D
P
-
YM
L
ER
A
E
I
M
RGP
V
S
V
L
YG
KS
S
PGG
LL
NMV
S
KR
P
T
TEP
LKEV
-----
Q
--
FK
A
------
G
T
D
SL
FQ
T
GF
D
F
S
DA
L
DD
DG
VYS
Y
R
LT
G
LA
R
S
A
N
A
Q
QKGSE
E
Q
R
YAIAPA
--
F
TW
RP
D
-
D
K
T
NF
T
F
LS
Y
-
FQN
E
------
P
E
T
G
YYGW
-
LP
KE
GT
V
-----
-E
P
L
--
PN
GK
--
RL
P
TDF
N
E
G
AK
N
NTYSRNEK
M
V
GY
S
F
D
H
E
F
N
DT
FTVR
Q
N
LR
F
A
E
N
K
--
-----
-
T
SQ
-------------------
NS
V
Y
G
Y
G
VC
S
D
PANAYSKQ
--------
CAALAPADKGH
Y
L
A
R
-
--
KY
------
VV
D
DE
K
L
QNF
S
V
D
TQ
L
QS
KF
AT
GDI
D
H
T
L
LT
G
V
----------
D
F
MR
MR
N
------------
D
I
NAW
F
G
YD
DS
V
P
LL
D
-
L
--
Y
N
P
-------------
VNTD
-
FD
FNAKDPDNSGPYRI
L
N
KQ
K
Q
T
-
-
-
G
V
Y
VQ
D
QAQ
W
-
D
KVLVT
LG
G
R
-------
Y
DWAD
Q
-
ESLN
R
--------------
VAGTTD
-----
KR
DD
K
QF
----
T
W
RG
G
VNY
L
F
D
N
GVT
P
Y
F
SY
S
E
SF
E
P
---------
S
S
-
QV
G
KD
G
NI
-
F
A
P
S
K
G
KQ
YE
-------
V
G
V
K
YVPE
D
RP
IV
V
T
G
A
V
Y
N
L
T
K
T
N
NL
M
A
DP
-
E
G
S
F
F
SVEG
GE
I
R
--------
AR
GVE
I
E
AK
---
A
AL
S
A
SVN
V
VG
SYTY
T
DAE
YT
--
TDTTY
K
G
-
N
TP
AQV
P
-----
KHMASLW
A
D
Y
T
F
F
DG
P
L
SG
-
LT
L
G
-----
T
G
G
R
Y
TG
--
S
S
Y
---
GD
P
A
N
-
S
F
K
V
--
GSY
T
V
VD
ALV
RY
D
LARVGMA
GS
N
VALH
VNNLFD
RE
Y
V
AS
CF
--
NT
YG
CF
W
GA
E
R
Q
V
VA
T
A
T
F
R
F
fig|364106.8.peg.293
Escherichia coli UTI89 (16-747/747)
IAV
V
V
A
T
A
V
-----
-
SG
MS
---
-
-----
-
---
V
Y
A
Q
A
A
V
E
P
KE-
D
T
IT
VTA
-
A
P
---
AP
Q
E
SAW
G
-
-
P
A
A
T
IAARQSAT
GTK
TDT
P
IQ
KV
PQS
IS
VV
T
A
E
E
M
A
L
H
Q
PK
SV
K
E
A
L
S
Y
TPGV
---
S
V
G
T
R
GAS
N
T
Y
D
HLI
I
RGF
-
AAEGQ
SQ
N
NY
L
--
-
N
G
L
K
-
LQGNF
Y
N
--
DA
VI
D
P
-
YM
L
ER
A
E
I
M
RGP
V
S
V
L
YG
KS
S
PGG
LL
NMV
S
KR
P
T
TEP
LKEV
-----
Q
--
FK
A
------
G
T
D
SL
FQ
T
GF
D
F
S
DA
L
DD
DG
VYS
Y
R
LT
G
LA
R
S
A
N
A
Q
QKGSE
E
Q
R
YAIAPA
--
F
TW
RP
D
-
D
K
T
NF
T
F
LS
Y
-
FQN
E
------
P
E
T
G
YYGW
-
LP
KE
GT
V
-----
-E
P
L
--
PN
GK
--
RL
P
TDF
N
E
G
AK
N
NTYSRNEK
M
V
GY
S
F
D
H
E
F
N
DT
FTVR
Q
N
LR
F
A
E
N
K
--
-----
-
T
SQ
-------------------
NS
V
Y
G
Y
G
VC
S
D
PANAYSKQ
--------
CAALAPADKGH
Y
L
A
R
-
--
KY
------
VV
D
DE
K
L
QNF
S
V
D
TQ
L
QS
KF
AT
GDI
D
H
T
L
LT
G
V
----------
D
F
MR
MR
N
------------
D
I
NAW
F
G
YD
DS
V
P
LL
D
-
L
--
Y
N
P
-------------
VNTD
-
FD
FNAKDPDNSGPYRI
L
N
KQ
K
Q
T
-
-
-
G
V
Y
VQ
D
QAQ
W
-
D
KVLVT
LG
G
R
-------
Y
DWAD
Q
-
ESLN
R
--------------
VAGTTD
-----
KR
DD
K
QF
----
T
W
RG
G
VNY
L
F
D
N
GVT
P
Y
F
SY
S
E
SF
E
P
---------
S
S
-
QV
G
KD
G
NI
-
F
A
P
S
K
G
KQ
YE
-------
V
G
V
K
YVPE
D
RP
IV
V
T
G
A
V
Y
N
L
T
K
T
N
NL
M
A
DP
-
E
G
S
F
F
SVEG
GE
I
R
--------
AR
GVE
I
E
AK
---
A
AL
S
A
SVN
V
VG
SYTY
T
DAE
YT
--
TDTTY
K
G
-
N
TP
AQV
P
-----
KHMASLW
A
D
Y
T
F
F
DG
P
L
SG
-
LT
L
G
-----
T
G
G
R
Y
TG
--
S
S
Y
---
GD
P
A
N
-
S
F
K
V
--
GSY
T
V
VD
ALV
RY
D
LARVGMA
GS
N
VALH
VNNLFD
RE
Y
V
AS
CF
--
NT
YG
CF
W
GA
E
R
Q
V
VA
T
A
T
F
R
F
fig|562.376.peg.1148
Escherichia coli WV_060327 (16-747/747)
IAV
V
V
A
T
A
V
-----
-
SG
MS
---
-
-----
-
---
V
Y
A
Q
A
A
V
E
P
KE-
D
T
IT
VTA
-
A
P
---
AP
Q
E
SAW
G
-
-
P
A
A
T
IAARQSAT
GTK
TDT
P
IQ
KV
PQS
IS
VV
T
A
E
E
M
A
L
H
Q
PK
SV
K
E
A
L
S
Y
TPGV
---
S
V
G
T
R
GAS
N
T
Y
D
HLI
I
RGF
-
AAEGQ
SQ
N
NY
L
--
-
N
G
L
K
-
LQGNF
Y
N
--
DA
VI
D
P
-
YM
L
ER
A
E
I
M
RGP
V
S
V
L
YG
KS
S
PGG
LL
NMV
S
KR
P
T
TEP
LKEV
-----
Q
--
FK
A
------
G
T
D
SL
FQ
T
GF
D
F
S
DA
L
DD
DG
VYS
Y
R
LT
G
LA
R
S
A
N
A
Q
QKGSE
E
Q
R
YAIAPA
--
F
TW
RP
D
-
D
K
T
NF
T
F
LS
Y
-
FQN
E
------
P
E
T
G
YYGW
-
LP
KE
GT
V
-----
-E
P
L
--
PN
GK
--
RL
P
TDF
N
E
G
AK
N
NTYSRNEK
M
V
GY
S
F
D
H
E
F
N
DT
FTVR
Q
N
LR
F
A
E
N
K
--
-----
-
T
SQ
-------------------
NS
V
Y
G
Y
G
VC
S
D
PANAYSKQ
--------
CAALAPADKGH
Y
L
A
R
-
--
KY
------
VV
D
DE
K
L
QNF
S
V
D
TQ
L
QS
KF
AT
GDI
D
H
T
L
LT
G
V
----------
D
F
MR
MR
N
------------
D
I
NAW
F
G
YD
DS
V
P
LL
D
-
L
--
Y
N
P
-------------
VNTD
-
FD
FNAKDPDNSGPYRI
L
N
KQ
K
Q
T
-
-
-
G
V
Y
VQ
D
QAQ
W
-
D
KVLVT
LG
G
R
-------
Y
DWAD
Q
-
ESLN
R
--------------
VAGTTD
-----
KR
DD
K
QF
----
T
W
RG
G
VNY
L
F
D
N
GVT
P
Y
F
SY
S
E
SF
E
P
---------
S
S
-
QV
G
KD
G
NI
-
F
A
P
S
K
G
KQ
YE
-------
V
G
V
K
YVPE
D
RP
IV
V
T
G
A
V
Y
N
L
T
K
T
N
NL
M
A
DP
-
E
G
S
F
F
SVEG
GE
I
R
--------
AR
GVE
I
E
AK
---
A
AL
S
A
SVN
V
VG
SYTY
T
DAE
YT
--
TDTTY
K
G
-
N
TP
AQV
P
-----
KHMASLW
A
D
Y
T
F
F
DG
P
L
SG
-
LT
L
G
-----
T
G
G
R
Y
TG
--
S
S
Y
---
GD
P
A
N
-
S
F
K
V
--
GSY
T
V
VD
ALV
RY
D
LARVGMA
GS
N
VALH
VNNLFD
RE
Y
V
AS
CF
--
NT
YG
CF
W
GA
E
R
Q
V
VA
T
A
T
F
R
F
fig|562.371.peg.892
Escherichia coli 1044A (16-747/747)
IAV
V
V
A
T
A
V
-----
-
SG
MS
---
-
-----
-
---
V
Y
A
Q
A
A
V
E
L
KE-
D
T
IT
VTA
-
A
P
---
AP
Q
E
SAW
G
-
-
P
A
A
T
IAARQSAT
GTK
TDT
P
IQ
KV
PQS
IS
VV
T
A
E
E
M
A
L
H
Q
PK
SV
K
E
A
L
S
Y
TPGV
---
S
V
G
T
R
GAS
N
T
Y
D
HLI
I
RGF
-
AAEGQ
SQ
N
NY
L
--
-
N
G
L
K
-
LQGNF
Y
N
--
DA
VI
D
P
-
YM
L
ER
A
E
I
M
RGP
V
S
V
L
YG
KS
S
PGG
LL
NMV
S
KR
P
T
TEP
LKEV
-----
Q
--
FK
A
------
G
T
D
SL
FQ
T
GF
D
F
S
DA
L
DD
DG
VYS
Y
R
LT
G
LA
R
S
A
N
A
Q
QKGSE
E
Q
R
YAIAPA
--
F
TW
RP
D
-
D
K
T
NF
T
F
LS
Y
-
FQN
E
------
P
E
T
G
YYGW
-
LP
KE
GT
V
-----
-E
P
L
--
PN
GK
--
RL
P
TDF
N
E
G
AK
N
NTYSRNEK
M
V
GY
S
F
D
H
E
F
N
DT
FTVR
Q
N
LR
F
A
E
N
K
--
-----
-
T
SQ
-------------------
NS
V
Y
G
Y
G
VC
S
D
PANAYSKQ
--------
CAALAPADKGH
Y
L
A
R
-
--
KY
------
VV
D
DE
K
L
QNF
S
V
D
TQ
L
QS
KF
AT
GDI
D
H
T
L
LT
G
V
----------
D
F
MR
MR
N
------------
D
I
NAW
F
G
YD
DS
V
P
LL
D
-
L
--
Y
N
P
-------------
VNTD
-
FD
FNAKDPANSGPYRI
L
N
KQ
K
Q
T
-
-
-
G
V
Y
VQ
D
QAQ
W
-
D
KVLVT
LG
G
R
-------
Y
DWAD
Q
-
ESLN
R
--------------
VAGTTD
-----
KR
DD
K
QF
----
T
W
RG
G
VNY
L
F
D
N
GVT
P
Y
F
SY
S
E
SF
E
P
---------
S
S
-
QV
G
KD
G
NI
-
F
A
P
S
K
G
KQ
YE
-------
V
G
V
K
YVPE
D
RP
IV
V
T
G
A
V
Y
N
L
T
K
T
N
NL
M
A
DP
-
E
G
S
F
F
SVEG
GE
I
R
--------
AR
GVE
I
E
AK
---
A
AL
S
A
SVN
V
VG
SYTY
T
DAE
YT
--
TDTTY
K
G
-
N
TP
AQV
P
-----
KHMASLW
A
D
Y
T
F
F
DG
P
L
SG
-
LT
L
G
-----
T
G
G
R
Y
TG
--
S
S
Y
---
GD
P
A
N
-
S
F
K
V
--
GSY
T
V
VD
ALV
RY
D
LARVGMA
GS
N
VALH
VNNLFD
RE
Y
V
AS
CF
--
NT
YG
CF
W
GA
E
R
Q
V
VA
T
A
T
F
R
F
fig|562.373.peg.2109
Escherichia coli 1125A (16-747/747)
IAV
V
V
A
T
A
V
-----
-
SG
MS
---
-
-----
-
---
V
Y
A
Q
A
A
V
E
P
KE-
D
T
IT
VTA
-
A
P
---
AP
Q
E
SAW
G
-
-
P
A
A
T
IAARQSAT
GTK
TDT
P
IQ
KV
PQS
IS
VV
T
A
E
E
M
A
L
H
Q
PK
SV
K
E
A
L
S
Y
TPGV
---
S
V
G
T
R
GAS
N
T
Y
D
HLI
I
RGF
-
AAEGQ
SQ
N
NY
L
--
-
N
G
L
K
-
LQGNF
Y
N
--
DA
VI
D
P
-
YM
L
ER
A
E
I
M
RGP
V
S
V
L
YG
KS
S
PGG
LL
NMV
S
KR
P
T
TEP
LKEV
-----
Q
--
FK
A
------
G
T
D
SL
FQ
T
GF
D
F
S
DA
L
DD
DG
VYS
Y
R
LT
G
LA
R
S
A
N
A
Q
QKGSE
E
Q
R
YAIAPA
--
F
TW
RP
D
-
D
K
T
NF
T
F
LS
Y
-
FQN
E
------
P
E
T
G
YYGW
-
LP
KE
GT
V
-----
-E
P
L
--
PN
GK
--
RL
P
TDF
N
E
G
AK
N
NTYSRNEK
M
V
GY
S
F
D
H
E
F
N
DT
FTVR
Q
N
LR
F
A
E
N
K
--
-----
-
T
SQ
-------------------
NS
V
Y
G
Y
G
VC
S
D
PANAYSKQ
--------
CAALAPADKGH
Y
L
A
R
-
--
KY
------
VV
D
DE
K
L
QNF
S
V
D
TQ
L
QS
KF
AT
GDI
D
H
T
L
LT
G
V
----------
D
F
MR
MR
N
------------
D
I
NAW
F
G
YD
DS
V
P
LL
D
-
L
--
Y
N
P
-------------
VNTD
-
FD
FNAKDPANSGPYRI
L
N
KQ
K
Q
T
-
-
-
G
V
Y
VQ
D
QAQ
W
-
D
KVLVT
LG
G
R
-------
Y
DWAD
Q
-
ESLN
R
--------------
VAGTTD
-----
KR
DD
K
QF
----
T
W
RG
G
VNY
L
F
D
N
GVT
P
Y
F
SY
S
E
SF
E
P
---------
S
S
-
QV
G
KD
G
NI
-
F
A
P
S
K
G
KQ
YE
-------
V
G
V
K
YVPE
D
RP
IV
V
T
G
A
V
Y
N
L
T
K
T
N
NL
M
A
DP
-
E
G
S
F
F
SVEG
GE
I
R
--------
AR
GVE
I
E
AK
---
A
AL
S
A
SVN
V
VG
SYTY
T
DAE
YT
--
TDTTY
K
G
-
N
TP
AQV
P
-----
KHMASLW
A
D
Y
T
F
F
DG
P
L
SG
-
LT
L
G
-----
T
G
G
R
Y
TG
--
S
S
Y
---
GD
P
A
N
-
S
F
K
V
--
GSY
T
V
VD
ALV
RY
D
LARVGMA
GS
N
VALH
VNNLFD
RE
Y
V
AS
CF
--
NT
YG
CF
W
GA
E
R
Q
V
VA
T
A
T
F
R
F
fig|562.372.peg.2959
Escherichia coli 1212A (16-747/747)
IAV
V
V
A
T
A
V
-----
-
SG
MS
---
-
-----
-
---
V
Y
A
Q
A
A
V
E
P
KE-
D
T
IT
VTA
-
A
P
---
AP
Q
E
SAW
G
-
-
P
A
A
T
IAARQSAT
GTK
TDT
P
IQ
KV
PQS
IS
VV
T
A
E
E
M
A
L
H
Q
PK
SV
K
E
A
L
S
Y
TPGV
---
S
V
G
T
R
GAS
N
T
Y
D
HLI
I
RGF
-
AAEGQ
SQ
N
NY
L
--
-
N
G
L
K
-
LQGNF
Y
N
--
DA
VI
D
P
-
YM
L
ER
A
E
I
M
RGP
V
S
V
L
YG
KS
S
PGG
LL
NMV
S
KR
P
T
TEP
LKEV
-----
Q
--
FK
A
------
G
T
D
SL
FQ
T
GF
D
F
S
DA
L
DD
DG
VYS
Y
R
LT
G
LA
R
S
A
N
A
Q
QKGSE
E
Q
R
YAIAPA
--
F
TW
RP
D
-
D
K
T
NF
T
F
LS
Y
-
FQN
E
------
P
E
T
G
YYGW
-
LP
KE
GT
V
-----
-E
P
L
--
PN
GK
--
RL
P
TDF
N
E
G
AK
N
NTYSRNEK
M
V
GY
S
F
D
H
E
F
N
DT
FTVR
Q
N
LR
F
A
E
N
K
--
-----
-
T
SQ
-------------------
NS
V
Y
G
Y
G
VC
S
D
PANAYSKQ
--------
CAALAPADKGH
Y
L
A
R
-
--
KY
------
VV
D
DE
K
L
QNF
S
V
D
TQ
L
QS
KF
AT
GDI
D
H
T
L
LT
G
V
----------
D
F
MR
MR
N
------------
D
I
NAW
F
G
YD
DS
V
P
LL
D
-
L
--
Y
N
P
-------------
VNTD
-
FD
FNAKDPANSGPYRI
L
N
KQ
K
Q
T
-
-
-
G
V
Y
VQ
D
QAQ
W
-
D
KVLVT
LG
G
R
-------
Y
DWAD
Q
-
ESLN
R
--------------
VAGTTD
-----
KR
DD
K
QF
----
T
W
RG
G
VNY
L
F
D
N
GVT
P
Y
F
SY
S
E
SF
E
P
---------
S
S
-
QV
G
KD
G
NI
-
F
A
P
S
K
G
KQ
YE
-------
V
G
V
K
YVPE
D
RP
IV
V
T
G
A
V
Y
N
L
T
K
T
N
NL
M
A
DP
-
E
G
S
F
F
SVEG
GE
I
R
--------
AR
GVE
I
E
AK
---
A
AL
S
A
SVN
V
VG
SYTY
T
DAE
YT
--
TDTTY
K
G
-
N
TP
AQV
P
-----
KHMASLW
A
D
Y
T
F
F
DG
P
L
SG
-
LT
L
G
-----
T
G
G
R
Y
TG
--
S
S
Y
---
GD
P
A
N
-
S
F
K
V
--
GSY
T
V
VD
ALV
RY
D
LARVGMA
GS
N
VALH
VNNLFD
RE
Y
V
AS
CF
--
NT
YG
CF
W
GA
E
R
Q
V
VA
T
A
T
F
R
F
fig|562.374.peg.2150
Escherichia coli 536A (16-747/747)
IAV
V
V
A
T
A
V
-----
-
SG
MS
---
-
-----
-
---
V
Y
A
Q
A
A
V
E
P
KE-
D
T
IT
VTA
-
A
P
---
AP
Q
E
SAW
G
-
-
P
A
A
T
IAARQSAT
GTK
TDT
P
IQ
KV
PQS
IS
VV
T
A
E
E
M
A
L
H
Q
PK
SV
K
E
A
L
S
Y
TPGV
---
S
V
G
T
R
GAS
N
T
Y
D
HLI
I
RGF
-
AAEGQ
SQ
N
NY
L
--
-
N
G
L
K
-
LQGNF
Y
N
--
DA
VI
D
P
-
YM
L
ER
A
E
I
M
RGP
V
S
V
L
YG
KS
S
PGG
LL
NMV
S
KR
P
T
TEP
LKEV
-----
Q
--
FK
A
------
G
T
D
SL
FQ
T
GF
D
F
S
DA
L
DD
DG
VYS
Y
R
LT
G
LA
R
S
A
N
A
Q
QKGSE
E
Q
R
YAIAPA
--
F
TW
RP
D
-
D
K
T
NF
T
F
LS
Y
-
FQN
E
------
P
E
T
G
YYGW
-
LP
KE
GT
V
-----
-E
P
L
--
PN
GK
--
RL
P
TDF
N
E
G
AK
N
NTYSRNEK
M
V
GY
S
F
D
H
E
F
N
DT
FTVR
Q
N
LR
F
A
E
N
K
--
-----
-
T
SQ
-------------------
NS
V
Y
G
Y
G
VC
S
D
PANAYSKQ
--------
CAALAPADKGH
Y
L
A
R
-
--
KY
------
VV
D
DE
K
L
QNF
S
V
D
TQ
L
QS
KF
AT
GDI
D
H
T
L
LT
G
V
----------
D
F
MR
MR
N
------------
D
I
NAW
F
G
YD
DS
V
P
LL
D
-
L
--
Y
N
P
-------------
VNTD
-
FD
FNAKDPANSGPYRI
L
N
KQ
K
Q
T
-
-
-
G
V
Y
VQ
D
QAQ
W
-
D
KVLVT
LG
G
R
-------
Y
DWAD
Q
-
ESLN
R
--------------
VAGTTD
-----
KR
DD
K
QF
----
T
W
RG
G
VNY
L
F
D
N
GVT
P
Y
F
SY
S
E
SF
E
P
---------
S
S
-
QV
G
KD
G
NI
-
F
A
P
S
K
G
KQ
YE
-------
V
G
V
K
YVPE
D
RP
IV
V
T
G
A
V
Y
N
L
T
K
T
N
NL
M
A
DP
-
E
G
S
F
F
SVEG
GE
I
R
--------
AR
GVE
I
E
AK
---
A
AL
S
A
SVN
V
VG
SYTY
T
DAE
YT
--
TDTTY
K
G
-
N
TP
AQV
P
-----
KHMASLW
A
D
Y
T
F
F
DG
P
L
SG
-
LT
L
G
-----
T
G
G
R
Y
TG
--
S
S
Y
---
GD
P
A
N
-
S
F
K
V
--
GSY
T
V
VD
ALV
RY
D
LARVGMA
GS
N
VALH
VNNLFD
RE
Y
V
AS
CF
--
NT
YG
CF
W
GA
E
R
Q
V
VA
T
A
T
F
R
F
fig|83334.1.peg.242
Escherichia coli O157:H7 (16-747/747)
IAV
V
V
A
T
A
V
-----
-
SG
MS
---
-
-----
-
---
V
Y
A
Q
A
A
V
E
L
KE-
D
T
IT
VTA
-
A
P
---
AP
Q
E
SAW
G
-
-
P
A
A
T
IAARQSAT
GTK
TDT
P
IQ
KV
PQS
IS
VV
T
A
E
E
M
A
L
H
Q
PK
SV
K
E
A
L
S
Y
TPGV
---
S
V
G
T
R
GAS
N
T
Y
D
HLI
I
RGF
-
AAEGQ
SQ
N
NY
L
--
-
N
G
L
K
-
LQGNF
Y
N
--
DA
VI
D
P
-
YM
L
ER
A
E
I
M
RGP
V
S
V
L
YG
KS
S
PGG
LL
NMV
S
KR
P
T
TEP
LKEV
-----
Q
--
FK
A
------
G
T
D
SL
FQ
T
GF
D
F
S
DA
L
DD
DG
VYS
Y
R
LT
G
LA
R
S
A
N
A
Q
QKGSE
E
Q
R
YAIAPA
--
F
TW
RP
D
-
D
K
T
NF
T
F
LS
Y
-
FQN
E
------
P
E
T
G
YYGW
-
LP
KE
GT
V
-----
-E
P
L
--
PN
GK
--
RL
P
TDF
N
E
G
AK
N
NTYSRNEK
M
V
GY
S
F
D
H
E
F
N
DT
FTVR
Q
N
LR
F
A
E
N
K
--
-----
-
T
SQ
-------------------
NS
V
Y
G
Y
G
VC
S
D
PANAYSKQ
--------
CAALAPADKGH
Y
L
A
R
-
--
KY
------
VV
D
DE
K
L
QNF
S
V
D
TQ
L
QS
KF
AT
GDI
D
H
T
L
LT
G
V
----------
D
F
MR
MR
N
------------
D
I
NAW
F
G
YD
DS
V
P
LL
D
-
L
--
Y
N
P
-------------
VNTD
-
FD
FNAKDPANSGPYRI
L
N
KQ
K
Q
T
-
-
-
G
V
Y
VQ
D
QAQ
W
-
D
KVLVT
LG
G
R
-------
Y
DWAD
Q
-
ESLN
R
--------------
VAGTTD
-----
KR
DD
K
QF
----
T
W
RG
G
VNY
L
F
D
N
GVT
P
Y
F
SY
S
E
SF
E
P
---------
S
S
-
QV
G
KD
G
NI
-
F
A
P
S
K
G
KQ
YE
-------
V
G
V
K
YVPE
D
RP
IV
V
T
G
A
V
Y
N
L
T
K
T
N
NL
M
A
DP
-
E
G
S
F
F
SVEG
GE
I
R
--------
AR
GVE
I
E
AK
---
A
AL
S
A
SVN
V
VG
SYTY
T
DAE
YT
--
TDTTY
K
G
-
N
TP
AQV
P
-----
KHMASLW
A
D
Y
T
F
F
DG
P
L
SG
-
LT
L
G
-----
T
G
G
R
Y
TG
--
S
S
Y
---
GD
P
A
N
-
S
F
K
V
--
GSY
T
V
VD
ALV
RY
D
LARVGMA
GS
N
VALH
VNNLFD
RE
Y
V
AS
CF
--
NT
YG
CF
W
GA
E
R
Q
V
VA
T
A
T
F
R
F
fig|155864.1.peg.154
Escherichia coli O157:H7 EDL933 (16-747/747)
IAV
V
V
A
T
A
V
-----
-
SG
MS
---
-
-----
-
---
V
Y
A
Q
A
A
V
E
L
KE-
D
T
IT
VTA
-
A
P
---
AP
Q
E
SAW
G
-
-
P
A
A
T
IAARQSAT
GTK
TDT
P
IQ
KV
PQS
IS
VV
T
A
E
E
M
A
L
H
Q
PK
SV
K
E
A
L
S
Y
TPGV
---
S
V
G
T
R
GAS
N
T
Y
D
HLI
I
RGF
-
AAEGQ
SQ
N
NY
L
--
-
N
G
L
K
-
LQGNF
Y
N
--
DA
VI
D
P
-
YM
L
ER
A
E
I
M
RGP
V
S
V
L
YG
KS
S
PGG
LL
NMV
S
KR
P
T
TEP
LKEV
-----
Q
--
FK
A
------
G
T
D
SL
FQ
T
GF
D
F
S
DA
L
DD
DG
VYS
Y
R
LT
G
LA
R
S
A
N
A
Q
QKGSE
E
Q
R
YAIAPA
--
F
TW
RP
D
-
D
K
T
NF
T
F
LS
Y
-
FQN
E
------
P
E
T
G
YYGW
-
LP
KE
GT
V
-----
-E
P
L
--
PN
GK
--
RL
P
TDF
N
E
G
AK
N
NTYSRNEK
M
V
GY
S
F
D
H
E
F
N
DT
FTVR
Q
N
LR
F
A
E
N
K
--
-----
-
T
SQ
-------------------
NS
V
Y
G
Y
G
VC
S
D
PANAYSKQ
--------
CAALAPADKGH
Y
L
A
R
-
--
KY
------
VV
D
DE
K
L
QNF
S
V
D
TQ
L
QS
KF
AT
GDI
D
H
T
L
LT
G
V
----------
D
F
MR
MR
N
------------
D
I
NAW
F
G
YD
DS
V
P
LL
D
-
L
--
Y
N
P
-------------
VNTD
-
FD
FNAKDPANSGPYRI
L
N
KQ
K
Q
T
-
-
-
G
V
Y
VQ
D
QAQ
W
-
D
KVLVT
LG
G
R
-------
Y
DWAD
Q
-
ESLN
R
--------------
VAGTTD
-----
KR
DD
K
QF
----
T
W
RG
G
VNY
L
F
D
N
GVT
P
Y
F
SY
S
E
SF
E
P
---------
S
S
-
QV
G
KD
G
NI
-
F
A
P
S
K
G
KQ
YE
-------
V
G
V
K
YVPE
D
RP
IV
V
T
G
A
V
Y
N
L
T
K
T
N
NL
M
A
DP
-
E
G
S
F
F
SVEG
GE
I
R
--------
AR
GVE
I
E
AK
---
A
AL
S
A
SVN
V
VG
SYTY
T
DAE
YT
--
TDTTY
K
G
-
N
TP
AQV
P
-----
KHMASLW
A
D
Y
T
F
F
DG
P
L
SG
-
LT
L
G
-----
T
G
G
R
Y
TG
--
S
S
Y
---
GD
P
A
N
-
S
F
K
V
--
GSY
T
V
VD
ALV
RY
D
LARVGMA
GS
N
VALH
VNNLFD
RE
Y
V
AS
CF
--
NT
YG
CF
W
GA
E
R
Q
V
VA
T
A
T
F
R
F
fig|155864.8.peg.155
Escherichia coli O157:H7 EDL933 (16-747/747)
IAV
V
V
A
T
A
V
-----
-
SG
MS
---
-
-----
-
---
V
Y
A
Q
A
A
V
E
L
KE-
D
T
IT
VTA
-
A
P
---
AP
Q
E
SAW
G
-
-
P
A
A
T
IAARQSAT
GTK
TDT
P
IQ
KV
PQS
IS
VV
T
A
E
E
M
A
L
H
Q
PK
SV
K
E
A
L
S
Y
TPGV
---
S
V
G
T
R
GAS
N
T
Y
D
HLI
I
RGF
-
AAEGQ
SQ
N
NY
L
--
-
N
G
L
K
-
LQGNF
Y
N
--
DA
VI
D
P
-
YM
L
ER
A
E
I
M
RGP
V
S
V
L
YG
KS
S
PGG
LL
NMV
S
KR
P
T
TEP
LKEV
-----
Q
--
FK
A
------
G
T
D
SL
FQ
T
GF
D
F
S
DA
L
DD
DG
VYS
Y
R
LT
G
LA
R
S
A
N
A
Q
QKGSE
E
Q
R
YAIAPA
--
F
TW
RP
D
-
D
K
T
NF
T
F
LS
Y
-
FQN
E
------
P
E
T
G
YYGW
-
LP
KE
GT
V
-----
-E
P
L
--
PN
GK
--
RL
P
TDF
N
E
G
AK
N
NTYSRNEK
M
V
GY
S
F
D
H
E
F
N
DT
FTVR
Q
N
LR
F
A
E
N
K
--
-----
-
T
SQ
-------------------
NS
V
Y
G
Y
G
VC
S
D
PANAYSKQ
--------
CAALAPADKGH
Y
L
A
R
-
--
KY
------
VV
D
DE
K
L
QNF
S
V
D
TQ
L
QS
KF
AT
GDI
D
H
T
L
LT
G
V
----------
D
F
MR
MR
N
------------
D
I
NAW
F
G
YD
DS
V
P
LL
D
-
L
--
Y
N
P
-------------
VNTD
-
FD
FNAKDPANSGPYRI
L
N
KQ
K
Q
T
-
-
-
G
V
Y
VQ
D
QAQ
W
-
D
KVLVT
LG
G
R
-------
Y
DWAD
Q
-
ESLN
R
--------------
VAGTTD
-----
KR
DD
K
QF
----
T
W
RG
G
VNY
L
F
D
N
GVT
P
Y
F
SY
S
E
SF
E
P
---------
S
S
-
QV
G
KD
G
NI
-
F
A
P
S
K
G
KQ
YE
-------
V
G
V
K
YVPE
D
RP
IV
V
T
G
A
V
Y
N
L
T
K
T
N
NL
M
A
DP
-
E
G
S
F
F
SVEG
GE
I
R
--------
AR
GVE
I
E
AK
---
A
AL
S
A
SVN
V
VG
SYTY
T
DAE
YT
--
TDTTY
K
G
-
N
TP
AQV
P
-----
KHMASLW
A
D
Y
T
F
F
DG
P
L
SG
-
LT
L
G
-----
T
G
G
R
Y
TG
--
S
S
Y
---
GD
P
A
N
-
S
F
K
V
--
GSY
T
V
VD
ALV
RY
D
LARVGMA
GS
N
VALH
VNNLFD
RE
Y
V
AS
CF
--
NT
YG
CF
W
GA
E
R
Q
V
VA
T
A
T
F
R
F
fig|444449.5.peg.4069
Escherichia coli O157:H7 str. EC4042 (16-747/747)
IAV
V
V
A
T
A
V
-----
-
SG
MS
---
-
-----
-
---
V
Y
A
Q
A
A
V
E
P
KE-
D
T
IT
VTA
-
A
P
---
AP
Q
E
SAW
G
-
-
P
A
A
T
IAARQSAT
GTK
TDT
P
IQ
KV
PQS
IS
VV
T
A
E
E
M
A
L
H
Q
PK
SV
K
E
A
L
S
Y
TPGV
---
S
V
G
T
R
GAS
N
T
Y
D
HLI
I
RGF
-
AAEGQ
SQ
N
NY
L
--
-
N
G
L
K
-
LQGNF
Y
N
--
DA
VI
D
P
-
YM
L
ER
A
E
I
M
RGP
V
S
V
L
YG
KS
S
PGG
LL
NMV
S
KR
P
T
TEP
LKEV
-----
Q
--
FK
A
------
G
T
D
SL
FQ
T
GF
D
F
S
DA
L
DD
DG
VYS
Y
R
LT
G
LA
R
S
A
N
A
Q
QKGSE
E
Q
R
YAIAPA
--
F
TW
RP
D
-
D
K
T
NF
T
F
LS
Y
-
FQN
E
------
P
E
T
G
YYGW
-
LP
KE
GT
V
-----
-E
P
L
--
PN
GK
--
RL
P
TDF
N
E
G
AK
N
NTYSRNEK
M
V
GY
S
F
D
H
E
F
N
DT
FTVR
Q
N
LR
F
A
E
N
K
--
-----
-
T
SQ
-------------------
NS
V
Y
G
Y
G
VC
S
D
PANAYSKQ
--------
CAALAPADKGH
Y
L
A
R
-
--
KY
------
VV
D
DE
K
L
QNF
S
V
D
TQ
L
QS
KF
AT
GDI
D
H
T
L
LT
G
V
----------
D
F
MR
MR
N
------------
D
I
NAW
F
G
YD
DS
V
P
LL
D
-
L
--
Y
N
P
-------------
VNTD
-
FD
FNAKDPANSGPYRI
L
N
KQ
K
Q
T
-
-
-
G
V
Y
VQ
D
QAQ
W
-
D
KVLVT
LG
G
R
-------
Y
DWAD
Q
-
ESLN
R
--------------
VAGTTD
-----
KR
DD
K
QF
----
T
W
RG
G
VNY
L
F
D
N
GVT
P
Y
F
SY
S
E
SF
E
P
---------
S
S
-
QV
G
KD
G
NI
-
F
A
P
S
K
G
KQ
YE
-------
V
G
V
K
YVPE
D
RP
IV
V
T
G
A
V
Y
N
L
T
K
T
N
NL
M
A
DP
-
E
G
S
F
F
SVEG
GE
I
R
--------
AR
GVE
I
E
AK
---
A
AL
S
A
SVN
V
VG
SYTY
T
DAE
YT
--
TDTTY
K
G
-
N
TP
AQV
P
-----
KHMASLW
A
D
Y
T
F
F
DG
P
L
SG
-
LT
L
G
-----
T
G
G
R
Y
TG
--
S
S
Y
---
GD
P
A
N
-
S
F
K
V
--
GSY
T
V
VD
ALV
RY
D
LARVGMA
GS
N
VALH
VNNLFD
RE
Y
V
AS
CF
--
NT
YG
CF
W
GA
E
R
Q
V
VA
T
A
T
F
R
F
fig|444448.5.peg.2826
Escherichia coli O157:H7 str. EC4045 (16-747/747)
IAV
V
V
A
T
A
V
-----
-
SG
MS
---
-
-----
-
---
V
Y
A
Q
A
A
V
E
P
KE-
D
T
IT
VTA
-
A
P
---
AP
Q
E
SAW
G
-
-
P
A
A
T
IAARQSAT
GTK
TDT
P
IQ
KV
PQS
IS
VV
T
A
E
E
M
A
L
H
Q
PK
SV
K
E
A
L
S
Y
TPGV
---
S
V
G
T
R
GAS
N
T
Y
D
HLI
I
RGF
-
AAEGQ
SQ
N
NY
L
--
-
N
G
L
K
-
LQGNF
Y
N
--
DA
VI
D
P
-
YM
L
ER
A
E
I
M
RGP
V
S
V
L
YG
KS
S
PGG
LL
NMV
S
KR
P
T
TEP
LKEV
-----
Q
--
FK
A
------
G
T
D
SL
FQ
T
GF
D
F
S
DA
L
DD
DG
VYS
Y
R
LT
G
LA
R
S
A
N
A
Q
QKGSE
E
Q
R
YAIAPA
--
F
TW
RP
D
-
D
K
T
NF
T
F
LS
Y
-
FQN
E
------
P
E
T
G
YYGW
-
LP
KE
GT
V
-----
-E
P
L
--
PN
GK
--
RL
P
TDF
N
E
G
AK
N
NTYSRNEK
M
V
GY
S
F
D
H
E
F
N
DT
FTVR
Q
N
LR
F
A
E
N
K
--
-----
-
T
SQ
-------------------
NS
V
Y
G
Y
G
VC
S
D
PANAYSKQ
--------
CAALAPADKGH
Y
L
A
R
-
--
KY
------
VV
D
DE
K
L
QNF
S
V
D
TQ
L
QS
KF
AT
GDI
D
H
T
L
LT
G
V
----------
D
F
MR
MR
N
------------
D
I
NAW
F
G
YD
DS
V
P
LL
D
-
L
--
Y
N
P
-------------
VNTD
-
FD
FNAKDPANSGPYRI
L
N
KQ
K
Q
T
-
-
-
G
V
Y
VQ
D
QAQ
W
-
D
KVLVT
LG
G
R
-------
Y
DWAD
Q
-
ESLN
R
--------------
VAGTTD
-----
KR
DD
K
QF
----
T
W
RG
G
VNY
L
F
D
N
GVT
P
Y
F
SY
S
E
SF
E
P
---------
S
S
-
QV
G
KD
G
NI
-
F
A
P
S
K
G
KQ
YE
-------
V
G
V
K
YVPE
D
RP
IV
V
T
G
A
V
Y
N
L
T
K
T
N
NL
M
A
DP
-
E
G
S
F
F
SVEG
GE
I
R
--------
AR
GVE
I
E
AK
---
A
AL
S
A
SVN
V
VG
SYTY
T
DAE
YT
--
TDTTY
K
G
-
N
TP
AQV
P
-----
KHMASLW
A
D
Y
T
F
F
DG
P
L
SG
-
LT
L
G
-----
T
G
G
R
Y
TG
--
S
S
Y
---
GD
P
A
N
-
S
F
K
V
--
GSY
T
V
VD
ALV
RY
D
LARVGMA
GS
N
VALH
VNNLFD
RE
Y
V
AS
CF
--
NT
YG
CF
W
GA
E
R
Q
V
VA
T
A
T
F
R
F
fig|444453.5.peg.3429
Escherichia coli O157:H7 str. EC4076 (16-747/747)
IAV
V
V
A
T
A
V
-----
-
SG
MS
---
-
-----
-
---
V
Y
A
Q
A
A
V
E
P
KE-
D
T
IT
VTA
-
A
P
---
AP
Q
E
SAW
G
-
-
P
A
A
T
IAARQSAT
GTK
TDT
P
IQ
KV
PQS
IS
VV
T
A
E
E
M
A
L
H
Q
PK
SV
K
E
A
L
S
Y
TPGV
---
S
V
G
T
R
GAS
N
T
Y
D
HLI
I
RGF
-
AAEGQ
SQ
N
NY
L
--
-
N
G
L
K
-
LQGNF
Y
N
--
DA
VI
D
P
-
YM
L
ER
A
E
I
M
RGP
V
S
V
L
YG
KS
S
PGG
LL
NMV
S
KR
P
T
TEP
LKEV
-----
Q
--
FK
A
------
G
T
D
SL
FQ
T
GF
D
F
S
DA
L
DD
DG
VYS
Y
R
LT
G
LA
R
S
A
N
A
Q
QKGSE
E
Q
R
YAIAPA
--
F
TW
RP
D
-
D
K
T
NF
T
F
LS
Y
-
FQN
E
------
P
E
T
G
YYGW
-
LP
KE
GT
V
-----
-E
P
L
--
PN
GK
--
RL
P
TDF
N
E
G
AK
N
NTYSRNEK
M
V
GY
S
F
D
H
E
F
N
DT
FTVR
Q
N
LR
F
A
E
N
K
--
-----
-
T
SQ
-------------------
NS
V
Y
G
Y
G
VC
S
D
PANAYSKQ
--------
CAALAPADKGH
Y
L
A
R
-
--
KY
------
VV
D
DE
K
L
QNF
S
V
D
TQ
L
QS
KF
AT
GDI
D
H
T
L
LT
G
V
----------
D
F
MR
MR
N
------------
D
I
NAW
F
G
YD
DS
V
P
LL
D
-
L
--
Y
N
P
-------------
VNTD
-
FD
FNAKDPANSGPYRI
L
N
KQ
K
Q
T
-
-
-
G
V
Y
VQ
D
QAQ
W
-
D
KVLVT
LG
G
R
-------
Y
DWAD
Q
-
ESLN
R
--------------
VAGTTD
-----
KR
DD
K
QF
----
T
W
RG
G
VNY
L
F
D
N
GVT
P
Y
F
SY
S
E
SF
E
P
---------
S
S
-
QV
G
KD
G
NI
-
F
A
P
S
K
G
KQ
YE
-------
V
G
V
K
YVPE
D
RP
IV
V
T
G
A
V
Y
N
L
T
K
T
N
NL
M
A
DP
-
E
G
S
F
F
SVEG
GE
I
R
--------
AR
GVE
I
E
AK
---
A
AL
S
A
SVN
V
VG
SYTY
T
DAE
YT
--
TDTTY
K
G
-
N
TP
AQV
P
-----
KHMASLW
A
D
Y
T
F
F
DG
P
L
SG
-
LT
L
G
-----
T
G
G
R
Y
TG
--
S
S
Y
---
GD
P
A
N
-
S
F
K
V
--
GSY
T
V
VD
ALV
RY
D
LARVGMA
GS
N
VALH
VNNLFD
RE
Y
V
AS
CF
--
NT
YG
CF
W
GA
E
R
Q
V
VA
T
A
T
F
R
F
fig|444451.5.peg.4464
Escherichia coli O157:H7 str. EC4196 (16-747/747)
IAV
V
V
A
T
A
V
-----
-
SG
MS
---
-
-----
-
---
V
Y
A
Q
A
A
V
E
P
KE-
D
T
IT
VTA
-
A
P
---
AP
Q
E
SAW
G
-
-
P
A
A
T
IAARQSAT
GTK
TDT
P
IQ
KV
PQS
IS
VV
T
A
E
E
M
A
L
H
Q
PK
SV
K
E
A
L
S
Y
TPGV
---
S
V
G
T
R
GAS
N
T
Y
D
HLI
I
RGF
-
AAEGQ
SQ
N
NY
L
--
-
N
G
L
K
-
LQGNF
Y
N
--
DA
VI
D
P
-
YM
L
ER
A
E
I
M
RGP
V
S
V
L
YG
KS
S
PGG
LL
NMV
S
KR
P
T
TEP
LKEV
-----
Q
--
FK
A
------
G
T
D
SL
FQ
T
GF
D
F
S
DA
L
DD
DG
VYS
Y
R
LT
G
LA
R
S
A
N
A
Q
QKGSE
E
Q
R
YAIAPA
--
F
TW
RP
D
-
D
K
T
NF
T
F
LS
Y
-
FQN
E
------
P
E
T
G
YYGW
-
LP
KE
GT
V
-----
-E
P
L
--
PN
GK
--
RL
P
TDF
N
E
G
AK
N
NTYSRNEK
M
V
GY
S
F
D
H
E
F
N
DT
FTVR
Q
N
LR
F
A
E
N
K
--
-----
-
T
SQ
-------------------
NS
V
Y
G
Y
G
VC
S
D
PANAYSKQ
--------
CAALAPADKGH
Y
L
A
R
-
--
KY
------
VV
D
DE
K
L
QNF
S
V
D
TQ
L
QS
KF
AT
GDI
D
H
T
L
LT
G
V
----------
D
F
MR
MR
N
------------
D
I
NAW
F
G
YD
DS
V
P
LL
D
-
L
--
Y
N
P
-------------
VNTD
-
FD
FNAKDPANSGPYRI
L
N
KQ
K
Q
T
-
-
-
G
V
Y
VQ
D
QAQ
W
-
D
KVLVT
LG
G
R
-------
Y
DWAD
Q
-
ESLN
R
--------------
VAGTTD
-----
KR
DD
K
QF
----
T
W
RG
G
VNY
L
F
D
N
GVT
P
Y
F
SY
S
E
SF
E
P
---------
S
S
-
QV
G
KD
G
NI
-
F
A
P
S
K
G
KQ
YE
-------
V
G
V
K
YVPE
D
RP
IV
V
T
G
A
V
Y
N
L
T
K
T
N
NL
M
A
DP
-
E
G
S
F
F
SVEG
GE
I
R
--------
AR
GVE
I
E
AK
---
A
AL
S
A
SVN
V
VG
SYTY
T
DAE
YT
--
TDTTY
K
G
-
N
TP
AQV
P
-----
KHMASLW
A
D
Y
T
F
F
DG
P
L
SG
-
LT
L
G
-----
T
G
G
R
Y
TG
--
S
S
Y
---
GD
P
A
N
-
S
F
K
V
--
GSY
T
V
VD
ALV
RY
D
LARVGMA
GS
N
VALH
VNNLFD
RE
Y
V
AS
CF
--
NT
YG
CF
W
GA
E
R
Q
V
VA
T
A
T
F
R
F
fig|478005.5.peg.4180
Escherichia coli O157:H7 str. EC4486 (16-747/747)
IAV
V
V
A
T
A
V
-----
-
SG
MS
---
-
-----
-
---
V
Y
A
Q
A
A
V
E
P
KE-
D
T
IT
VTA
-
A
P
---
AP
Q
E
SAW
G
-
-
P
A
A
T
IAARQSAT
GTK
TDT
P
IQ
KV
PQS
IS
VV
T
A
E
E
M
A
L
H
Q
PK
SV
K
E
A
L
S
Y
TPGV
---
S
V
G
T
R
GAS
N
T
Y
D
HLI
I
RGF
-
AAEGQ
SQ
N
NY
L
--
-
N
G
L
K
-
LQGNF
Y
N
--
DA
VI
D
P
-
YM
L
ER
A
E
I
M
RGP
V
S
V
L
YG
KS
S
PGG
LL
NMV
S
KR
P
T
TEP
LKEV
-----
Q
--
FK
A
------
G
T
D
SL
FQ
T
GF
D
F
S
DA
L
DD
DG
VYS
Y
R
LT
G
LA
R
S
A
N
A
Q
QKGSE
E
Q
R
YAIAPA
--
F
TW
RP
D
-
D
K
T
NF
T
F
LS
Y
-
FQN
E
------
P
E
T
G
YYGW
-
LP
KE
GT
V
-----
-E
P
L
--
PN
GK
--
RL
P
TDF
N
E
G
AK
N
NTYSRNEK
M
V
GY
S
F
D
H
E
F
N
DT
FTVR
Q
N
LR
F
A
E
N
K
--
-----
-
T
SQ
-------------------
NS
V
Y
G
Y
G
VC
S
D
PANAYSKQ
--------
CAALAPADKGH
Y
L
A
R
-
--
KY
------
VV
D
DE
K
L
QNF
S
V
D
TQ
L
QS
KF
AT
GDI
D
H
T
L
LT
G
V
----------
D
F
MR
MR
N
------------
D
I
NAW
F
G
YD
DS
V
P
LL
D
-
L
--
Y
N
P
-------------
VNTD
-
FD
FNAKDPANSGPYRI
L
N
KQ
K
Q
T
-
-
-
G
V
Y
VQ
D
QAQ
W
-
D
KVLVT
LG
G
R
-------
Y
DWAD
Q
-
ESLN
R
--------------
VAGTTD
-----
KR
DD
K
QF
----
T
W
RG
G
VNY
L
F
D
N
GVT
P
Y
F
SY
S
E
SF
E
P
---------
S
S
-
QV
G
KD
G
NI
-
F
A
P
S
K
G
KQ
YE
-------
V
G
V
K
YVPE
D
RP
IV
V
T
G
A
V
Y
N
L
T
K
T
N
NL
M
A
DP
-
E
G
S
F
F
SVEG
GE
I
R
--------
AR
GVE
I
E
AK
---
A
AL
S
A
SVN
V
VG
SYTY
T
DAE
YT
--
TDTTY
K
G
-
N
TP
AQV
P
-----
KHMASLW
A
D
Y
T
F
F
DG
P
L
SG
-
LT
L
G
-----
T
G
G
R
Y
TG
--
S
S
Y
---
GD
P
A
N
-
S
F
K
V
--
GSY
T
V
VD
ALV
RY
D
LARVGMA
GS
N
VALH
VNNLFD
RE
Y
V
AS
CF
--
NT
YG
CF
W
GA
E
R
Q
V
VA
T
A
T
F
R
F
fig|478006.5.peg.4657
Escherichia coli O157:H7 str. EC4501 (16-747/747)
IAV
V
V
A
T
A
V
-----
-
SG
MS
---
-
-----
-
---
V
Y
A
Q
A
A
V
E
L
KE-
D
T
IT
VTA
-
A
P
---
AP
Q
E
SAW
G
-
-
P
A
A
T
IAARQSAT
GTK
TDT
P
IQ
KV
PQS
IS
VV
T
A
E
E
M
A
L
H
Q
PK
SV
K
E
A
L
S
Y
TPGV
---
S
V
G
T
R
GAS
N
T
Y
D
HLI
I
RGF
-
AAEGQ
SQ
N
NY
L
--
-
N
G
L
K
-
LQGNF
Y
N
--
DA
VI
D
P
-
YM
L
ER
A
E
I
M
RGP
V
S
V
L
YG
KS
S
PGG
LL
NMV
S
KR
P
T
TEP
LKEV
-----
Q
--
FK
A
------
G
T
D
SL
FQ
T
GF
D
F
S
DA
L
DD
DG
VYS
Y
R
LT
G
LA
R
S
A
N
A
Q
QKGSE
E
Q
R
YAIAPA
--
F
TW
RP
D
-
D
K
T
NF
T
F
LS
Y
-
FQN
E
------
P
E
T
G
YYGW
-
LP
KE
GT
V
-----
-E
P
L
--
PN
GK
--
RL
P
TDF
N
E
G
AK
N
NTYSRNEK
M
V
GY
S
F
D
H
E
F
N
DT
FTVR
Q
N
LR
F
A
E
N
K
--
-----
-
T
SQ
-------------------
NS
V
Y
G
Y
G
VC
S
D
PANAYSKQ
--------
CAALAPADKGH
Y
L
A
R
-
--
KY
------
VV
D
DE
K
L
QNF
S
V
D
TQ
L
QS
KF
AT
GDI
D
H
T
L
LT
G
V
----------
D
F
MR
MR
N
------------
D
I
NAW
F
G
YD
DS
V
P
LL
D
-
L
--
Y
N
P
-------------
VNTD
-
FD
FNAKDPANSGPYRI
L
N
KQ
K
Q
T
-
-
-
G
V
Y
VQ
D
QAQ
W
-
D
KVLVT
LG
G
R
-------
Y
DWAD
Q
-
ESLN
R
--------------
VAGTTD
-----
KR
DD
K
QF
----
T
W
RG
G
VNY
L
F
D
N
GVT
P
Y
F
SY
S
E
SF
E
P
---------
S
S
-
QV
G
KD
G
NI
-
F
A
P
S
K
G
KQ
YE
-------
V
G
V
K
YVPE
D
RP
IV
V
T
G
A
V
Y
N
L
T
K
T
N
NL
M
A
DP
-
E
G
S
F
F
SVEG
GE
I
R
--------
AR
GVE
I
E
AK
---
A
AL
S
A
SVN
V
VG
SYTY
T
DAE
YT
--
TDTTY
K
G
-
N
TP
AQV
P
-----
KHMASLW
A
D
Y
T
F
F
DG
P
L
SG
-
LT
L
G
-----
T
G
G
R
Y
TG
--
S
S
Y
---
GD
P
A
N
-
S
F
K
V
--
GSY
T
V
VD
ALV
RY
D
LARVGMA
GS
N
VALH
VNNLFD
RE
Y
V
AS
CF
--
NT
YG
CF
W
GA
E
R
Q
V
VA
T
A
T
F
R
F
fig|478007.5.peg.4883
Escherichia coli O157:H7 str. EC508 (16-747/747)
IAV
V
V
A
T
A
V
-----
-
SG
MS
---
-
-----
-
---
V
Y
A
Q
A
A
V
E
P
KE-
D
T
IT
VTA
-
A
P
---
AP
Q
E
SAW
G
-
-
P
A
A
T
IAARQSAT
GTK
TDT
P
IQ
KV
PQS
IS
VV
T
A
E
E
M
A
L
H
Q
PK
SV
K
E
A
L
S
Y
TPGV
---
S
V
G
T
R
GAS
N
T
Y
D
HLI
I
RGF
-
AAEGQ
SQ
N
NY
L
--
-
N
G
L
K
-
LQGNF
Y
N
--
DA
VI
D
P
-
YM
L
ER
A
E
I
M
RGP
V
S
V
L
YG
KS
S
PGG
LL
NMV
S
KR
P
T
TEP
LKEV
-----
Q
--
FK
A
------
G
T
D
SL
FQ
T
GF
D
F
S
DA
L
DD
DG
VYS
Y
R
LT
G
LA
R
S
A
N
A
Q
QKGSE
E
Q
R
YAIAPA
--
F
TW
RP
D
-
D
K
T
NF
T
F
LS
Y
-
FQN
E
------
P
E
T
G
YYGW
-
LP
KE
GT
V
-----
-E
P
L
--
PN
GK
--
RL
P
TDF
N
E
G
AK
N
NTYSRNEK
M
V
GY
S
F
D
H
E
F
N
DT
FTVR
Q
N
LR
F
A
E
N
K
--
-----
-
T
SQ
-------------------
NS
V
Y
G
Y
G
VC
S
D
PANAYSKQ
--------
CAALAPADKGH
Y
L
A
R
-
--
KY
------
VV
D
DE
K
L
QNF
S
V
D
TQ
L
QS
KF
AT
GDI
D
H
T
L
LT
G
V
----------
D
F
MR
MR
N
------------
D
I
NAW
F
G
YD
DS
V
P
LL
D
-
L
--
Y
N
P
-------------
VNTD
-
FD
FNAKDPANSGPYRI
L
N
KQ
K
Q
T
-
-
-
G
V
Y
VQ
D
QAQ
W
-
D
KVLVT
LG
G
R
-------
Y
DWAD
Q
-
ESLN
R
--------------
VAGTTD
-----
KR
DD
K
QF
----
T
W
RG
G
VNY
L
F
D
N
GVT
P
Y
F
SY
S
E
SF
E
P
---------
S
S
-
QV
G
KD
G
NI
-
F
A
P
S
K
G
KQ
YE
-------
V
G
V
K
YVPE
D
RP
IV
V
T
G
A
V
Y
N
L
T
K
T
N
NL
M
A
DP
-
E
G
S
F
F
SVEG
GE
I
R
--------
AR
GVE
I
E
AK
---
A
AL
S
A
SVN
V
VG
SYTY
T
DAE
YT
--
TDTTY
K
G
-
N
TP
AQV
P
-----
KHMASLW
A
D
Y
T
F
F
DG
P
L
SG
-
LT
L
G
-----
T
G
G
R
Y
TG
--
S
S
Y
---
GD
P
A
N
-
S
F
K
V
--
GSY
T
V
VD
ALV
RY
D
LARVGMA
GS
N
VALH
VNNLFD
RE
Y
V
AS
CF
--
NT
YG
CF
W
GA
E
R
Q
V
VA
T
A
T
F
R
F
fig|478008.5.peg.4347
Escherichia coli O157:H7 str. EC869 (16-747/747)
IAV
V
V
A
T
A
V
-----
-
SG
MS
---
-
-----
-
---
V
Y
A
Q
A
A
V
E
P
KE-
D
T
IT
VTA
-
A
P
---
AP
Q
E
SAW
G
-
-
P
A
A
T
IAARQSAT
GTK
TDT
P
IQ
KV
PQS
IS
VV
T
A
E
E
M
A
L
H
Q
PK
SV
K
E
A
L
S
Y
TPGV
---
S
V
G
T
R
GAS
N
T
Y
D
HLI
I
RGF
-
AAEGQ
SQ
N
NY
L
--
-
N
G
L
K
-
LQGNF
Y
N
--
DA
VI
D
P
-
YM
L
ER
A
E
I
M
RGP
V
S
V
L
YG
KS
S
PGG
LL
NMV
S
KR
P
T
TEP
LKEV
-----
Q
--
FK
A
------
G
T
D
SL
FQ
T
GF
D
F
S
DA
L
DD
DG
VYS
Y
R
LT
G
LA
R
S
A
N
A
Q
QKGSE
E
Q
R
YAIAPA
--
F
TW
RP
D
-
D
K
T
NF
T
F
LS
Y
-
FQN
E
------
P
E
T
G
YYGW
-
LP
KE
GT
V
-----
-E
P
L
--
PN
GK
--
RL
P
TDF
N
E
G
AK
N
NTYSRNEK
M
V
GY
S
F
D
H
E
F
N
DT
FTVR
Q
N
LR
F
A
E
N
K
--
-----
-
T
SQ
-------------------
NS
V
Y
G
Y
G
VC
S
D
PANAYSKQ
--------
CAALAPADKGH
Y
L
A
R
-
--
KY
------
VV
D
DE
K
L
QNF
S
V
D
TQ
L
QS
KF
AT
GDI
D
H
T
L
LT
G
V
----------
D
F
MR
MR
N
------------
D
I
NAW
F
G
YD
DS
V
P
LL
D
-
L
--
Y
N
P
-------------
VNTD
-
FD
FNAKDPANSGPYRI
L
N
KQ
K
Q
T
-
-
-
G
V
Y
VQ
D
QAQ
W
-
D
KVLVT
LG
G
R
-------
Y
DWAD
Q
-
ESLN
R
--------------
VAGTTD
-----
KR
DD
K
QF
----
T
W
RG
G
VNY
L
F
D
N
GVT
P
Y
F
SY
S
E
SF
E
P
---------
S
S
-
QV
G
KD
G
NI
-
F
A
P
S
K
G
KQ
YE
-------
V
G
V
K
YVPE
D
RP
IV
V
T
G
A
V
Y
N
L
T
K
T
N
NL
M
A
DP
-
E
G
S
F
F
SVEG
GE
I
R
--------
AR
GVE
I
E
AK
---
A
AL
S
A
SVN
V
VG
SYTY
T
DAE
YT
--
TDTTY
K
G
-
N
TP
AQV
P
-----
KHMASLW
A
D
Y
T
F
F
DG
P
L
SG
-
LT
L
G
-----
T
G
G
R
Y
TG
--
S
S
Y
---
GD
P
A
N
-
S
F
K
V
--
GSY
T
V
VD
ALV
RY
D
LARVGMA
GS
N
VALH
VNNLFD
RE
Y
V
AS
CF
--
NT
YG
CF
W
GA
E
R
Q
V
VA
T
A
T
F
R
F
fig|570506.3.peg.1157
Escherichia coli O157:H7 str. FRIK966 (16-747/747)
IAV
V
V
A
T
A
V
-----
-
SG
MS
---
-
-----
-
---
V
Y
A
Q
A
A
V
E
P
KE-
D
T
IT
VTA
-
A
P
---
AP
Q
E
SAW
G
-
-
P
A
A
T
IAARQSAT
GTK
TDT
P
IQ
KV
PQS
IS
VV
T
A
E
E
M
A
L
H
Q
PK
SV
K
E
A
L
S
Y
TPGV
---
S
V
G
T
R
GAS
N
T
Y
D
HLI
I
RGF
-
AAEGQ
SQ
N
NY
L
--
-
N
G
L
K
-
LQGNF
Y
N
--
DA
VI
D
P
-
YM
L
ER
A
E
I
M
RGP
V
S
V
L
YG
KS
S
PGG
LL
NMV
S
KR
P
T
TEP
LKEV
-----
Q
--
FK
A
------
G
T
D
SL
FQ
T
GF
D
F
S
DA
L
DD
DG
VYS
Y
R
LT
G
LA
R
S
A
N
A
Q
QKGSE
E
Q
R
YAIAPA
--
F
TW
RP
D
-
D
K
T
NF
T
F
LS
Y
-
FQN
E
------
P
E
T
G
YYGW
-
LP
KE
GT
V
-----
-E
P
L
--
PN
GK
--
RL
P
TDF
N
E
G
AK
N
NTYSRNEK
M
V
GY
S
F
D
H
E
F
N
DT
FTVR
Q
N
LR
F
A
E
N
K
--
-----
-
T
SQ
-------------------
NS
V
Y
G
Y
G
VC
S
D
PANAYSKQ
--------
CAALAPADKGH
Y
L
A
R
-
--
KY
------
VV
D
DE
K
L
QNF
S
V
D
TQ
L
QS
KF
AT
GDI
D
H
T
L
LT
G
V
----------
D
F
MR
MR
N
------------
D
I
NAW
F
G
YD
DS
V
P
LL
D
-
L
--
Y
N
P
-------------
VNTD
-
FD
FNAKDPANSGPYRI
L
N
KQ
K
Q
T
-
-
-
G
V
Y
VQ
D
QAQ
W
-
D
KVLVT
LG
G
R
-------
Y
DWAD
Q
-
ESLN
R
--------------
VAGTTD
-----
KR
DD
K
QF
----
T
W
RG
G
VNY
L
F
D
N
GVT
P
Y
F
SY
S
E
SF
E
P
---------
S
S
-
QV
G
KD
G
NI
-
F
A
P
S
K
G
KQ
YE
-------
V
G
V
K
YVPE
D
RP
IV
V
T
G
A
V
Y
N
L
T
K
T
N
NL
M
A
DP
-
E
G
S
F
F
SVEG
GE
I
R
--------
AR
GVE
I
E
AK
---
A
AL
S
A
SVN
V
VG
SYTY
T
DAE
YT
--
TDTTY
K
G
-
N
TP
AQV
P
-----
KHMASLW
A
D
Y
T
F
F
DG
P
L
SG
-
LT
L
G
-----
T
G
G
R
Y
TG
--
S
S
Y
---
GD
P
A
N
-
S
F
K
V
--
GSY
T
V
VD
ALV
RY
D
LARVGMA
GS
N
VALH
VNNLFD
RE
Y
V
AS
CF
--
NT
YG
CF
W
GA
E
R
Q
V
VA
T
A
T
F
R
F
fig|386585.9.peg.254
Escherichia coli O157:H7 str. Sakai (16-747/747)
IAV
V
V
A
T
A
V
-----
-
SG
MS
---
-
-----
-
---
V
Y
A
Q
A
A
V
E
L
KE-
D
T
IT
VTA
-
A
P
---
AP
Q
E
SAW
G
-
-
P
A
A
T
IAARQSAT
GTK
TDT
P
IQ
KV
PQS
IS
VV
T
A
E
E
M
A
L
H
Q
PK
SV
K
E
A
L
S
Y
TPGV
---
S
V
G
T
R
GAS
N
T
Y
D
HLI
I
RGF
-
AAEGQ
SQ
N
NY
L
--
-
N
G
L
K
-
LQGNF
Y
N
--
DA
VI
D
P
-
YM
L
ER
A
E
I
M
RGP
V
S
V
L
YG
KS
S
PGG
LL
NMV
S
KR
P
T
TEP
LKEV
-----
Q
--
FK
A
------
G
T
D
SL
FQ
T
GF
D
F
S
DA
L
DD
DG
VYS
Y
R
LT
G
LA
R
S
A
N
A
Q
QKGSE
E
Q
R
YAIAPA
--
F
TW
RP
D
-
D
K
T
NF
T
F
LS
Y
-
FQN
E
------
P
E
T
G
YYGW
-
LP
KE
GT
V
-----
-E
P
L
--
PN
GK
--
RL
P
TDF
N
E
G
AK
N
NTYSRNEK
M
V
GY
S
F
D
H
E
F
N
DT
FTVR
Q
N
LR
F
A
E
N
K
--
-----
-
T
SQ
-------------------
NS
V
Y
G
Y
G
VC
S
D
PANAYSKQ
--------
CAALAPADKGH
Y
L
A
R
-
--
KY
------
VV
D
DE
K
L
QNF
S
V
D
TQ
L
QS
KF
AT
GDI
D
H
T
L
LT
G
V
----------
D
F
MR
MR
N
------------
D
I
NAW
F
G
YD
DS
V
P
LL
D
-
L
--
Y
N
P
-------------
VNTD
-
FD
FNAKDPANSGPYRI
L
N
KQ
K
Q
T
-
-
-
G
V
Y
VQ
D
QAQ
W
-
D
KVLVT
LG
G
R
-------
Y
DWAD
Q
-
ESLN
R
--------------
VAGTTD
-----
KR
DD
K
QF
----
T
W
RG
G
VNY
L
F
D
N
GVT
P
Y
F
SY
S
E
SF
E
P
---------
S
S
-
QV
G
KD
G
NI
-
F
A
P
S
K
G
KQ
YE
-------
V
G
V
K
YVPE
D
RP
IV
V
T
G
A
V
Y
N
L
T
K
T
N
NL
M
A
DP
-
E
G
S
F
F
SVEG
GE
I
R
--------
AR
GVE
I
E
AK
---
A
AL
S
A
SVN
V
VG
SYTY
T
DAE
YT
--
TDTTY
K
G
-
N
TP
AQV
P
-----
KHMASLW
A
D
Y
T
F
F
DG
P
L
SG
-
LT
L
G
-----
T
G
G
R
Y
TG
--
S
S
Y
---
GD
P
A
N
-
S
F
K
V
--
GSY
T
V
VD
ALV
RY
D
LARVGMA
GS
N
VALH
VNNLFD
RE
Y
V
AS
CF
--
NT
YG
CF
W
GA
E
R
Q
V
VA
T
A
T
F
R
F
fig|544404.4.peg.158
Escherichia coli O157:H7 str. TW14359 (16-747/747)
IAV
V
V
A
T
A
V
-----
-
SG
MS
---
-
-----
-
---
V
Y
A
Q
A
A
V
E
P
KE-
D
T
IT
VTA
-
A
P
---
AP
Q
E
SAW
G
-
-
P
A
A
T
IAARQSAT
GTK
TDT
P
IQ
KV
PQS
IS
VV
T
A
E
E
M
A
L
H
Q
PK
SV
K
E
A
L
S
Y
TPGV
---
S
V
G
T
R
GAS
N
T
Y
D
HLI
I
RGF
-
AAEGQ
SQ
N
NY
L
--
-
N
G
L
K
-
LQGNF
Y
N
--
DA
VI
D
P
-
YM
L
ER
A
E
I
M
RGP
V
S
V
L
YG
KS
S
PGG
LL
NMV
S
KR
P
T
TEP
LKEV
-----
Q
--
FK
A
------
G
T
D
SL
FQ
T
GF
D
F
S
DA
L
DD
DG
VYS
Y
R
LT
G
LA
R
S
A
N
A
Q
QKGSE
E
Q
R
YAIAPA
--
F
TW
RP
D
-
D
K
T
NF
T
F
LS
Y
-
FQN
E
------
P
E
T
G
YYGW
-
LP
KE
GT
V
-----
-E
P
L
--
PN
GK
--
RL
P
TDF
N
E
G
AK
N
NTYSRNEK
M
V
GY
S
F
D
H
E
F
N
DT
FTVR
Q
N
LR
F
A
E
N
K
--
-----
-
T
SQ
-------------------
NS
V
Y
G
Y
G
VC
S
D
PANAYSKQ
--------
CAALAPADKGH
Y
L
A
R
-
--
KY
------
VV
D
DE
K
L
QNF
S
V
D
TQ
L
QS
KF
AT
GDI
D
H
T
L
LT
G
V
----------
D
F
MR
MR
N
------------
D
I
NAW
F
G
YD
DS
V
P
LL
D
-
L
--
Y
N
P
-------------
VNTD
-
FD
FNAKDPANSGPYRI
L
N
KQ
K
Q
T
-
-
-
G
V
Y
VQ
D
QAQ
W
-
D
KVLVT
LG
G
R
-------
Y
DWAD
Q
-
ESLN
R
--------------
VAGTTD
-----
KR
DD
K
QF
----
T
W
RG
G
VNY
L
F
D
N
GVT
P
Y
F
SY
S
E
SF
E
P
---------
S
S
-
QV
G
KD
G
NI
-
F
A
P
S
K
G
KQ
YE
-------
V
G
V
K
YVPE
D
RP
IV
V
T
G
A
V
Y
N
L
T
K
T
N
NL
M
A
DP
-
E
G
S
F
F
SVEG
GE
I
R
--------
AR
GVE
I
E
AK
---
A
AL
S
A
SVN
V
VG
SYTY
T
DAE
YT
--
TDTTY
K
G
-
N
TP
AQV
P
-----
KHMASLW
A
D
Y
T
F
F
DG
P
L
SG
-
LT
L
G
-----
T
G
G
R
Y
TG
--
S
S
Y
---
GD
P
A
N
-
S
F
K
V
--
GSY
T
V
VD
ALV
RY
D
LARVGMA
GS
N
VALH
VNNLFD
RE
Y
V
AS
CF
--
NT
YG
CF
W
GA
E
R
Q
V
VA
T
A
T
F
R
F
fig|502346.5.peg.1109
Escherichia coli O157:H7 str. TW14588 (16-747/747)
IAV
V
V
A
T
A
V
-----
-
SG
MS
---
-
-----
-
---
V
Y
A
Q
A
A
V
E
L
KE-
D
T
IT
VTA
-
A
P
---
AP
Q
E
SAW
G
-
-
P
A
A
T
IAARQSAT
GTK
TDT
P
IQ
KV
PQS
IS
VV
T
A
E
E
M
A
L
H
Q
PK
SV
K
E
A
L
S
Y
TPGV
---
S
V
G
T
R
GAS
N
T
Y
D
HLI
I
RGF
-
AAEGQ
SQ
N
NY
L
--
-
N
G
L
K
-
LQGNF
Y
N
--
DA
VI
D
P
-
YM
L
ER
A
E
I
M
RGP
V
S
V
L
YG
KS
S
PGG
LL
NMV
S
KR
P
T
TEP
LKEV
-----
Q
--
FK
A
------
G
T
D
SL
FQ
T
GF
D
F
S
DA
L
DD
DG
VYS
Y
R
LT
G
LA
R
S
A
N
A
Q
QKGSE
E
Q
R
YAIAPA
--
F
TW
RP
D
-
D
K
T
NF
T
F
LS
Y
-
FQN
E
------
P
E
T
G
YYGW
-
LP
KE
GT
V
-----
-E
P
L
--
PN
GK
--
RL
P
TDF
N
E
G
AK
N
NTYSRNEK
M
V
GY
S
F
D
H
E
F
N
DT
FTVR
Q
N
LR
F
A
E
N
K
--
-----
-
T
SQ
-------------------
NS
V
Y
G
Y
G
VC
S
D
PANAYSKQ
--------
CAALAPADKGH
Y
L
A
R
-
--
KY
------
VV
D
DE
K
L
QNF
S
V
D
TQ
L
QS
KF
AT
GDI
D
H
T
L
LT
G
V
----------
D
F
MR
MR
N
------------
D
I
NAW
F
G
YD
DS
V
P
LL
D
-
L
--
Y
N
P
-------------
VNTD
-
FD
FNAKDPANSGPYRI
L
N
KQ
K
Q
T
-
-
-
G
V
Y
VQ
D
QAQ
W
-
D
KVLVT
LG
G
R
-------
Y
DWAD
Q
-
ESLN
R
--------------
VAGTTD
-----
KR
DD
K
QF
----
T
W
RG
G
VNY
L
F
D
N
GVT
P
Y
F
SY
S
E
SF
E
P
---------
S
S
-
QV
G
KD
G
NI
-
F
A
P
S
K
G
KQ
YE
-------
V
G
V
K
YVPE
D
RP
IV
V
T
G
A
V
Y
N
L
T
K
T
N
NL
M
A
DP
-
E
G
S
F
F
SVEG
GE
I
R
--------
AR
GVE
I
E
AK
---
A
AL
S
A
SVN
V
VG
SYTY
T
DAE
YT
--
TDTTY
K
G
-
N
TP
AQV
P
-----
KHMASLW
A
D
Y
T
F
F
DG
P
L
SG
-
LT
L
G
-----
T
G
G
R
Y
TG
--
S
S
Y
---
GD
P
A
N
-
S
F
K
V
--
GSY
T
V
VD
ALV
RY
D
LARVGMA
GS
N
VALH
VNNLFD
RE
Y
V
AS
CF
--
NT
YG
CF
W
GA
E
R
Q
V
VA
T
A
T
F
R
F
fig|749544.3.peg.1800
Escherichia coli MS 175-1 (16-747/747)
IAV
V
V
A
T
A
V
-----
-
SG
MS
---
-
-----
-
---
V
Y
A
Q
A
A
V
E
P
KE-
D
T
IT
VTA
-
A
P
---
AP
Q
E
SAW
G
-
-
P
A
A
T
IAARQSAT
GTK
TDT
P
IQ
KV
PQS
IS
VV
T
A
E
E
M
A
L
H
Q
PK
SV
K
E
A
L
S
Y
TPGV
---
S
V
G
T
R
GAS
N
T
Y
D
HLI
I
RGF
-
AAEGQ
SQ
N
NY
L
--
-
N
G
L
K
-
LQGNF
Y
N
--
DA
VI
D
P
-
YM
L
ER
A
E
I
M
RGP
V
S
V
L
YG
KS
S
PGG
LL
NMV
S
KR
P
T
TEP
LKEV
-----
Q
--
FK
A
------
G
T
D
SL
FQ
T
GF
D
F
S
DS
L
DD
DG
VYS
Y
R
LT
G
LA
R
S
A
N
A
Q
QKGSE
E
Q
R
YAIAPA
--
F
TW
RP
D
-
D
K
T
NF
T
F
LS
Y
-
FQN
E
------
P
E
T
G
YYGW
-
LP
KE
GT
V
-----
-E
P
L
--
PN
GK
--
RL
P
TDF
N
E
G
AK
N
NTYSRNEK
M
V
GY
S
F
D
H
E
F
N
DT
FTVR
Q
N
LR
F
A
E
N
K
--
-----
-
T
SQ
-------------------
NS
V
Y
G
Y
G
VC
S
D
PANAYSKQ
--------
CAALAPADKGH
Y
L
A
R
-
--
KY
------
VV
D
DE
K
L
QNF
S
V
D
TQ
L
QS
KF
AT
GDI
D
H
T
L
LT
G
V
----------
D
F
MR
MR
N
------------
D
I
NAW
F
G
YD
DS
V
P
LL
N
-
L
--
Y
N
P
-------------
VNTD
-
FD
FNAKDPANSGPYRI
L
N
KQ
K
Q
T
-
-
-
G
V
Y
VQ
D
QAQ
W
-
D
KVLVT
LG
G
R
-------
Y
DWAD
Q
-
ESLN
R
--------------
VAGTTD
-----
KR
DD
K
QF
----
T
W
RG
G
VNY
L
F
D
N
GVT
P
Y
F
SY
S
E
SF
E
P
---------
S
S
-
QV
G
KD
G
NI
-
F
A
P
S
K
G
KQ
YE
-------
V
G
V
K
YVPE
D
RP
IV
V
T
G
A
V
Y
N
L
T
K
T
N
NL
M
A
DP
-
E
G
S
F
F
SVEG
GE
I
R
--------
AR
GVE
I
E
AK
---
A
AL
S
A
SVN
V
VG
SYTY
T
DAE
YT
--
TDTTY
K
G
-
N
TP
AQV
P
-----
KHMASLW
A
D
Y
T
F
F
DG
P
L
SG
-
LT
L
G
-----
T
G
G
R
Y
TG
--
S
S
Y
---
GD
P
A
N
-
S
F
K
V
--
GSY
T
V
VD
ALV
RY
D
LARVGMA
GS
N
VALH
VNNLFD
RE
Y
V
AS
CF
--
NT
YG
CF
W
GA
E
R
Q
F
VA
T
A
T
F
R
F
fig|316385.5.peg.131
Escherichia coli str. K-12 substr. DH10B (16-747/747)
IAV
V
V
A
T
A
V
-----
-
SG
MS
---
-
-----
-
---
V
Y
A
Q
A
A
V
E
P
KE-
D
T
IT
VTA
-
A
P
---
AP
Q
E
SAW
G
-
-
P
A
A
T
IAARQSAT
GTK
TDT
P
IQ
KV
PQS
IS
VV
T
A
E
E
M
A
L
H
Q
PK
SV
K
E
A
L
S
Y
TPGV
---
S
V
G
T
R
GAS
N
T
Y
D
HLI
I
RGF
-
AAEGQ
SQ
N
NY
L
--
-
N
G
L
K
-
LQGNF
Y
N
--
DA
VI
D
P
-
YM
L
ER
A
E
I
M
RGP
V
S
V
L
YG
KS
S
PGG
LL
NMV
S
KR
P
T
TEP
LKEV
-----
Q
--
FK
A
------
G
T
D
SL
FQ
T
GF
D
F
S
DS
L
DD
DG
VYS
Y
R
LT
G
LA
R
S
A
N
A
Q
QKGSE
E
Q
R
YAIAPA
--
F
T
X
RP
D
-
D
K
T
NF
T
F
LS
Y
-
FQN
E
------
P
E
T
G
YYGW
-
LP
KE
GT
V
-----
-E
P
L
--
PN
GK
--
RL
P
TDF
N
E
G
AK
N
NTYSRNEK
M
V
GY
S
F
D
H
E
F
N
DT
FTVR
Q
N
LR
F
A
E
N
K
--
-----
-
T
SQ
-------------------
NS
V
Y
G
Y
G
VC
S
D
PANAYSKQ
--------
CAALAPADKGH
Y
L
A
R
-
--
KY
------
VV
D
DE
K
L
QNF
S
V
D
TQ
L
QS
KF
AT
GDI
D
H
T
L
LT
G
V
----------
D
F
MR
MR
N
------------
D
I
NAW
F
G
YD
DS
V
P
LL
N
-
L
--
Y
N
P
-------------
VNTD
-
FD
FNAKDPANSGPYRI
L
N
KQ
K
Q
T
-
-
-
G
V
Y
VQ
D
QAQ
W
-
D
KVLVT
LG
G
R
-------
Y
DWAD
Q
-
ESLN
R
--------------
VAGTTD
-----
KR
DD
K
QF
----
T
W
RG
G
VNY
L
F
D
N
GVT
P
Y
F
SY
S
E
SF
E
P
---------
S
S
-
QV
G
KD
G
NI
-
F
A
P
S
K
G
KQ
YE
-------
V
G
V
K
YVPE
D
RP
IV
V
T
G
A
V
Y
N
L
T
K
T
N
NL
M
A
DP
-
E
G
S
F
F
SVEG
GE
I
R
--------
AR
GVE
I
E
AK
---
A
AL
S
A
SVN
V
VG
SYTY
T
DAE
YT
--
TDTTY
K
G
-
N
TP
AQV
P
-----
KHMASLW
A
D
Y
T
F
F
DG
P
L
SG
-
LT
L
G
-----
T
G
G
R
Y
TG
--
S
S
Y
---
GD
P
A
N
-
S
F
K
V
--
GSY
T
V
VD
ALV
RY
D
LARVGMA
GS
N
VALH
VNNLFD
RE
Y
V
AS
CF
--
NT
YG
CF
W
GA
E
R
Q
V
VA
T
A
T
F
R
F
fig|316385.7.peg.133
Escherichia coli str. K-12 substr. DH10B (16-747/747)
IAV
V
V
A
T
A
V
-----
-
SG
MS
---
-
-----
-
---
V
Y
A
Q
A
A
V
E
P
KE-
D
T
IT
VTA
-
A
P
---
AP
Q
E
SAW
G
-
-
P
A
A
T
IAARQSAT
GTK
TDT
P
IQ
KV
PQS
IS
VV
T
A
E
E
M
A
L
H
Q
PK
SV
K
E
A
L
S
Y
TPGV
---
S
V
G
T
R
GAS
N
T
Y
D
HLI
I
RGF
-
AAEGQ
SQ
N
NY
L
--
-
N
G
L
K
-
LQGNF
Y
N
--
DA
VI
D
P
-
YM
L
ER
A
E
I
M
RGP
V
S
V
L
YG
KS
S
PGG
LL
NMV
S
KR
P
T
TEP
LKEV
-----
Q
--
FK
A
------
G
T
D
SL
FQ
T
GF
D
F
S
DS
L
DD
DG
VYS
Y
R
LT
G
LA
R
S
A
N
A
Q
QKGSE
E
Q
R
YAIAPA
--
F
T
X
RP
D
-
D
K
T
NF
T
F
LS
Y
-
FQN
E
------
P
E
T
G
YYGW
-
LP
KE
GT
V
-----
-E
P
L
--
PN
GK
--
RL
P
TDF
N
E
G
AK
N
NTYSRNEK
M
V
GY
S
F
D
H
E
F
N
DT
FTVR
Q
N
LR
F
A
E
N
K
--
-----
-
T
SQ
-------------------
NS
V
Y
G
Y
G
VC
S
D
PANAYSKQ
--------
CAALAPADKGH
Y
L
A
R
-
--
KY
------
VV
D
DE
K
L
QNF
S
V
D
TQ
L
QS
KF
AT
GDI
D
H
T
L
LT
G
V
----------
D
F
MR
MR
N
------------
D
I
NAW
F
G
YD
DS
V
P
LL
N
-
L
--
Y
N
P
-------------
VNTD
-
FD
FNAKDPANSGPYRI
L
N
KQ
K
Q
T
-
-
-
G
V
Y
VQ
D
QAQ
W
-
D
KVLVT
LG
G
R
-------
Y
DWAD
Q
-
ESLN
R
--------------
VAGTTD
-----
KR
DD
K
QF
----
T
W
RG
G
VNY
L
F
D
N
GVT
P
Y
F
SY
S
E
SF
E
P
---------
S
S
-
QV
G
KD
G
NI
-
F
A
P
S
K
G
KQ
YE
-------
V
G
V
K
YVPE
D
RP
IV
V
T
G
A
V
Y
N
L
T
K
T
N
NL
M
A
DP
-
E
G
S
F
F
SVEG
GE
I
R
--------
AR
GVE
I
E
AK
---
A
AL
S
A
SVN
V
VG
SYTY
T
DAE
YT
--
TDTTY
K
G
-
N
TP
AQV
P
-----
KHMASLW
A
D
Y
T
F
F
DG
P
L
SG
-
LT
L
G
-----
T
G
G
R
Y
TG
--
S
S
Y
---
GD
P
A
N
-
S
F
K
V
--
GSY
T
V
VD
ALV
RY
D
LARVGMA
GS
N
VALH
VNNLFD
RE
Y
V
AS
CF
--
NT
YG
CF
W
GA
E
R
Q
V
VA
T
A
T
F
R
F
fig|656414.3.peg.277
Escherichia coli H736 (16-747/747)
IAV
V
V
A
T
A
V
-----
-
SG
MS
---
-
-----
-
---
V
Y
A
Q
A
A
V
E
P
KE-
D
T
IT
VTA
-
A
P
---
AP
Q
E
SAW
G
-
-
P
A
A
T
IAARQSAT
GTK
TDT
P
IQ
KV
PQS
IS
VV
T
A
E
E
M
A
L
H
Q
PK
SV
K
E
A
L
S
Y
TPGV
---
S
V
G
T
R
GAS
N
T
Y
D
HLI
I
RGF
-
AAEGQ
SQ
N
NY
L
--
-
N
G
L
K
-
LQGNF
Y
N
--
DA
VI
D
P
-
YM
L
ER
A
E
I
M
RGP
V
S
V
L
YG
KS
S
PGG
LL
NMV
S
KR
P
T
TEP
LKEV
-----
Q
--
FK
A
------
G
T
D
SL
FQ
T
GF
D
F
S
DS
L
DD
DG
VYS
Y
R
LT
G
LA
R
S
A
N
A
Q
QKGSE
E
Q
R
YAIAPA
--
F
TW
RP
D
-
D
K
T
NF
T
F
LS
Y
-
FQN
E
------
P
E
T
G
YYGW
-
LP
KE
GT
V
-----
-E
P
L
--
PN
GK
--
RL
P
TDF
N
E
G
AK
N
NTYSRNEK
M
V
GY
S
F
D
H
E
F
N
DT
FTVR
Q
N
LR
F
A
E
N
K
--
-----
-
T
SQ
-------------------
NS
V
Y
G
Y
G
VC
S
D
PANAYSKQ
--------
CAALAPADKGH
Y
L
A
R
-
--
KY
------
VV
D
DE
K
L
QNF
S
V
D
TQ
L
QS
KF
AT
GDI
D
H
T
L
L
I
G
V
----------
D
F
MR
MR
N
------------
D
I
NAW
F
G
YD
DS
V
P
LL
N
-
L
--
Y
N
P
-------------
VNTD
-
FD
FNAKDPANSGPYRI
L
N
KQ
K
Q
T
-
-
-
G
V
Y
VQ
D
QAQ
W
-
D
KVLVT
LG
G
R
-------
Y
DWAD
Q
-
ESLN
R
--------------
VAGTTD
-----
KR
DD
K
QF
----
T
W
RG
G
VNY
L
F
D
N
GVT
P
Y
F
SY
S
E
SF
E
P
---------
S
S
-
QV
G
KD
G
NI
-
F
A
P
S
K
G
KQ
YE
-------
V
G
V
K
YVPE
D
RP
IV
V
T
G
A
V
Y
N
L
T
K
T
N
NL
M
A
DP
-
E
G
S
F
F
SVEG
GE
I
R
--------
AR
GVE
I
E
AK
---
A
AL
S
A
SVN
V
VG
SYTY
T
DAE
YT
--
TDTTY
K
G
-
N
TP
AQV
P
-----
KHMASLW
A
D
Y
T
F
F
DG
P
L
SG
-
LT
L
G
-----
T
G
G
R
Y
TG
--
S
S
Y
---
GD
P
A
N
-
S
F
K
V
--
GSY
T
V
VD
ALV
RY
D
LARVGMA
GS
N
VALH
VNNLFD
RE
Y
V
AS
CF
--
NT
YG
CF
W
GA
E
R
Q
V
VA
T
A
T
F
R
F
fig|1040638.4.peg.5717
Escherichia coli O104:H4 str. LB226692 (16-747/747)
IAV
V
V
A
T
A
V
-----
-
SG
MS
---
-
-----
-
---
V
Y
A
Q
A
A
V
E
P
KE-
D
T
IT
VTA
-
A
P
---
AP
Q
E
SAW
G
-
-
P
A
A
T
IAARQSAT
GTK
TDT
P
IQ
KV
PQS
IS
VV
T
A
E
E
M
A
L
H
Q
PK
SV
K
E
A
L
S
Y
TPGV
---
S
V
G
T
R
GAS
N
T
Y
D
HLI
I
RGF
-
AAEGQ
SQ
N
NY
L
--
-
N
G
L
K
-
LQGNF
Y
N
--
DA
VI
D
P
-
YM
L
ER
A
E
I
M
RGP
V
S
V
L
YG
KS
S
PGG
LL
NMV
S
KR
P
T
TEP
LKEV
-----
Q
--
FK
A
------
G
T
D
SL
FQ
T
GF
D
F
S
DS
L
DD
DG
VYS
Y
R
LT
G
LA
R
S
A
N
A
Q
QKGSE
E
Q
R
YAIAPA
--
F
TW
RP
D
-
D
K
T
NF
T
F
LS
Y
-
FQN
E
------
P
E
T
G
YYGW
-
LP
KE
GT
V
-----
-E
P
L
--
PN
GK
--
RL
P
TDF
N
E
G
AK
N
NTYSRNEK
M
V
GY
S
F
D
H
E
F
N
DT
FTVR
Q
N
LR
F
A
E
N
K
--
-----
-
T
SQ
-------------------
NS
V
Y
G
Y
G
VC
S
D
PANAYSKQ
--------
CAALAPADKGH
Y
L
A
R
-
--
KY
------
VV
D
DE
K
L
QNF
S
V
D
TQ
L
QS
KF
AT
GDI
D
H
T
L
LT
G
V
----------
D
F
MR
MR
N
------------
D
I
NAW
F
G
YD
DS
V
P
LL
N
-
L
--
Y
N
P
-------------
VNTD
-
FD
FNAKDPANSGPYRI
L
N
KQ
K
Q
T
-
-
-
G
V
Y
VQ
D
QAQ
W
-
D
KVLVT
LG
G
R
-------
Y
DWAD
Q
-
ESLN
R
--------------
VAGTTD
-----
KR
DD
K
QF
----
T
W
RG
G
VNY
L
F
D
N
GVT
P
Y
F
SY
S
E
SF
E
P
---------
S
S
-
QV
G
KD
G
NI
-
F
A
P
S
K
G
KQ
YE
-------
V
G
V
K
YVPE
D
RP
IV
V
T
G
A
V
Y
N
L
T
K
T
N
NL
M
A
DP
-
E
G
S
F
F
SVEG
GE
I
R
--------
AR
GVE
I
E
AK
---
A
AL
S
A
SVN
V
VG
SYTY
T
DAE
YT
--
TDTTY
K
G
-
N
TP
AQV
P
-----
KHMASLW
A
D
Y
T
F
F
DG
P
L
SG
-
LT
L
G
-----
T
G
G
R
Y
TG
--
S
S
Y
---
GD
P
A
N
-
S
F
K
V
--
GSY
T
V
VD
ALV
RY
D
LARVGMA
GS
N
VALH
VNNLFD
RE
Y
V
AS
CF
--
NT
YG
CF
W
GA
E
R
Q
V
VA
T
A
T
F
R
F
fig|6666666.5357.peg.2081
Escherichia coli TY-2482 (16-747/747)
IAV
V
V
A
T
A
V
-----
-
SG
MS
---
-
-----
-
---
V
Y
A
Q
A
A
V
E
P
KE-
D
T
IT
VTA
-
A
P
---
AP
Q
E
SAW
G
-
-
P
A
A
T
IAARQSAT
GTK
TDT
P
IQ
KV
PQS
IS
VV
T
A
E
E
M
A
L
H
Q
PK
SV
K
E
A
L
S
Y
TPGV
---
S
V
G
T
R
GAS
N
T
Y
D
HLI
I
RGF
-
AAEGQ
SQ
N
NY
L
--
-
N
G
L
K
-
LQGNF
Y
N
--
DA
VI
D
P
-
YM
L
ER
A
E
I
M
RGP
V
S
V
L
YG
KS
S
PGG
LL
NMV
S
KR
P
T
TEP
LKEV
-----
Q
--
FK
A
------
G
T
D
SL
FQ
T
GF
D
F
S
DS
L
DD
DG
VYS
Y
R
LT
G
LA
R
S
A
N
A
Q
QKGSE
E
Q
R
YAIAPA
--
F
TW
RP
D
-
D
K
T
NF
T
F
LS
Y
-
FQN
E
------
P
E
T
G
YYGW
-
LP
KE
GT
V
-----
-E
P
L
--
PN
GK
--
RL
P
TDF
N
E
G
AK
N
NTYSRNEK
M
V
GY
S
F
D
H
E
F
N
DT
FTVR
Q
N
LR
F
A
E
N
K
--
-----
-
T
SQ
-------------------
NS
V
Y
G
Y
G
VC
S
D
PANAYSKQ
--------
CAALAPADKGH
Y
L
A
R
-
--
KY
------
VV
D
DE
K
L
QNF
S
V
D
TQ
L
QS
KF
AT
GDI
D
H
T
L
LT
G
V
----------
D
F
MR
MR
N
------------
D
I
NAW
F
G
YD
DS
V
P
LL
N
-
L
--
Y
N
P
-------------
VNTD
-
FD
FNAKDPANSGPYRI
L
N
KQ
K
Q
T
-
-
-
G
V
Y
VQ
D
QAQ
W
-
D
KVLVT
LG
G
R
-------
Y
DWAD
Q
-
ESLN
R
--------------
VAGTTD
-----
KR
DD
K
QF
----
T
W
RG
G
VNY
L
F
D
N
GVT
P
Y
F
SY
S
E
SF
E
P
---------
S
S
-
QV
G
KD
G
NI
-
F
A
P
S
K
G
KQ
YE
-------
V
G
V
K
YVPE
D
RP
IV
V
T
G
A
V
Y
N
L
T
K
T
N
NL
M
A
DP
-
E
G
S
F
F
SVEG
GE
I
R
--------
AR
GVE
I
E
AK
---
A
AL
S
A
SVN
V
VG
SYTY
T
DAE
YT
--
TDTTY
K
G
-
N
TP
AQV
P
-----
KHMASLW
A
D
Y
T
F
F
DG
P
L
SG
-
LT
L
G
-----
T
G
G
R
Y
TG
--
S
S
Y
---
GD
P
A
N
-
S
F
K
V
--
GSY
T
V
VD
ALV
RY
D
LARVGMA
GS
N
VALH
VNNLFD
RE
Y
V
AS
CF
--
NT
YG
CF
W
GA
E
R
Q
V
VA
T
A
T
F
R
F
fig|550672.3.peg.4422
Escherichia coli B088 (16-747/747)
IAV
V
V
A
T
A
V
-----
-
SG
MS
---
-
-----
-
---
V
Y
A
Q
A
A
V
E
P
KE-
D
T
IT
VTA
-
A
P
---
AP
Q
E
SAW
G
-
-
P
A
A
T
IAARQSAT
GTK
TDT
P
IQ
KV
PQS
IS
VV
T
A
E
E
M
A
L
H
Q
PK
SV
K
E
A
L
S
Y
TPGV
---
S
V
G
T
R
GAS
N
T
Y
D
HLI
I
RGF
-
AAEGQ
SQ
N
NY
L
--
-
N
G
L
K
-
LQGNF
Y
N
--
DA
VI
D
P
-
YM
L
ER
A
E
I
M
RGP
V
S
V
L
YG
KS
S
PGG
LL
NMV
S
KR
P
T
TEP
LKEV
-----
Q
--
FK
A
------
G
T
D
SL
FQ
T
GF
D
F
S
DS
L
DD
DG
VYS
Y
R
LT
G
LA
R
S
A
N
A
Q
QKGSE
E
Q
R
YAIAPA
--
F
TW
RP
D
-
D
K
T
NF
T
F
LS
Y
-
FQN
E
------
P
E
T
G
YYGW
-
LP
KE
GT
V
-----
-E
P
L
--
PN
GK
--
RL
P
TDF
N
E
G
AK
N
NTYSRNEK
M
V
GY
S
F
D
H
E
F
N
DT
FTVR
Q
N
LR
F
A
E
N
K
--
-----
-
T
SQ
-------------------
NS
V
Y
G
Y
G
VC
S
D
PANAYSKQ
--------
CAALAPADKGH
Y
L
A
R
-
--
KY
------
VV
D
DE
K
L
QNF
S
V
D
TQ
L
QS
KF
AT
GDI
D
H
T
L
LT
G
V
----------
D
F
MR
MR
N
------------
D
I
NAW
F
G
YD
DS
V
P
LL
N
-
L
--
Y
N
P
-------------
VNTD
-
FD
FNAKDPANSGPYRI
L
N
KQ
K
Q
T
-
-
-
G
V
Y
VQ
D
QAQ
W
-
D
KVLVT
LG
G
R
-------
Y
DWAD
Q
-
ESLN
R
--------------
VAGTTD
-----
KR
DD
K
QF
----
T
W
RG
G
VNY
L
F
D
N
GVT
P
Y
F
SY
S
E
SF
E
P
---------
S
S
-
QV
G
KD
G
NI
-
F
A
P
S
K
G
KQ
YE
-------
V
G
V
K
YVPE
D
RP
IV
V
T
G
A
V
Y
N
L
T
K
T
N
NL
M
A
DP
-
E
G
S
F
F
SVEG
GE
I
R
--------
AR
GVE
I
E
AK
---
A
AL
S
A
SVN
V
VG
SYTY
T
DAE
YT
--
TDTTY
K
G
-
N
TP
AQV
P
-----
KHMASLW
A
D
Y
T
F
F
DG
P
L
SG
-
LT
L
G
-----
T
G
G
R
Y
TG
--
S
S
Y
---
GD
P
A
N
-
S
F
K
V
--
GSY
T
V
VD
ALV
RY
D
LARVGMA
GS
N
VALH
VNNLFD
RE
Y
V
AS
CF
--
NT
YG
CF
W
GA
E
R
Q
V
VA
T
A
T
F
R
F
fig|344601.3.peg.2602
Escherichia coli B171 (16-747/747)
IAV
V
V
A
T
A
V
-----
-
SG
MS
---
-
-----
-
---
V
Y
A
Q
A
A
V
E
P
KE-
D
T
IT
VTA
-
A
P
---
AP
Q
E
SAW
G
-
-
P
A
A
T
IAARQSAT
GTK
TDT
P
IQ
KV
PQS
IS
VV
T
A
E
E
M
A
L
H
Q
PK
SV
K
E
A
L
S
Y
TPGV
---
S
V
G
T
R
GAS
N
T
Y
D
HLI
I
RGF
-
AAEGQ
SQ
N
NY
L
--
-
N
G
L
K
-
LQGNF
Y
N
--
DA
VI
D
P
-
YM
L
ER
A
E
I
M
RGP
V
S
V
L
YG
KS
S
PGG
LL
NMV
S
KR
P
T
TEP
LKEV
-----
Q
--
FK
A
------
G
T
D
SL
FQ
T
GF
D
F
S
DS
L
DD
DG
VYS
Y
R
LT
G
LA
R
S
A
N
A
Q
QKGSE
E
Q
R
YAIAPA
--
F
TW
RP
D
-
D
K
T
NF
T
F
LS
Y
-
FQN
E
------
P
E
T
G
YYGW
-
LP
KE
GT
V
-----
-E
P
L
--
PN
GK
--
RL
P
TDF
N
E
G
AK
N
NTYSRNEK
M
V
GY
S
F
D
H
E
F
N
DT
FTVR
Q
N
LR
F
A
E
N
K
--
-----
-
T
SQ
-------------------
NS
V
Y
G
Y
G
VC
S
D
PANAYSKQ
--------
CAALAPADKGH
Y
L
A
R
-
--
KY
------
VV
D
DE
K
L
QNF
S
V
D
TQ
L
QS
KF
AT
GDI
D
H
T
L
LT
G
V
----------
D
F
MR
MR
N
------------
D
I
NAW
F
G
YD
DS
V
P
LL
N
-
L
--
Y
N
P
-------------
VNTD
-
FD
FNAKDPANSGPYRI
L
N
KQ
K
Q
T
-
-
-
G
V
Y
VQ
D
QAQ
W
-
D
KVLVT
LG
G
R
-------
Y
DWAD
Q
-
ESLN
R
--------------
VAGTTD
-----
KR
DD
K
QF
----
T
W
RG
G
VNY
L
F
D
N
GVT
P
Y
F
SY
S
E
SF
E
P
---------
S
S
-
QV
G
KD
G
NI
-
F
A
P
S
K
G
KQ
YE
-------
V
G
V
K
YVPE
D
RP
IV
V
T
G
A
V
Y
N
L
T
K
T
N
NL
M
A
DP
-
E
G
S
F
F
SVEG
GE
I
R
--------
AR
GVE
I
E
AK
---
A
AL
S
A
SVN
V
VG
SYTY
T
DAE
YT
--
TDTTY
K
G
-
N
TP
AQV
P
-----
KHMASLW
A
D
Y
T
F
F
DG
P
L
SG
-
LT
L
G
-----
T
G
G
R
Y
TG
--
S
S
Y
---
GD
P
A
N
-
S
F
K
V
--
GSY
T
V
VD
ALV
RY
D
LARVGMA
GS
N
VALH
VNNLFD
RE
Y
V
AS
CF
--
NT
YG
CF
W
GA
E
R
Q
V
VA
T
A
T
F
R
F
fig|340184.3.peg.1401
Escherichia coli B7A (16-747/747)
IAV
V
V
A
T
A
V
-----
-
SG
MS
---
-
-----
-
---
V
Y
A
Q
A
A
V
E
P
KE-
D
T
IT
VTA
-
A
P
---
AP
Q
E
SAW
G
-
-
P
A
A
T
IAARQSAT
GTK
TDT
P
IQ
KV
PQS
IS
VV
T
A
E
E
M
A
L
H
Q
PK
SV
K
E
A
L
S
Y
TPGV
---
S
V
G
T
R
GAS
N
T
Y
D
HLI
I
RGF
-
AAEGQ
SQ
N
NY
L
--
-
N
G
L
K
-
LQGNF
Y
N
--
DA
VI
D
P
-
YM
L
ER
A
E
I
M
RGP
V
S
V
L
YG
KS
S
PGG
LL
NMV
S
KR
P
T
TEP
LKEV
-----
Q
--
FK
A
------
G
T
D
SL
FQ
T
GF
D
F
S
DS
L
DD
DG
VYS
Y
R
LT
G
LA
R
S
A
N
A
Q
QKGSE
E
Q
R
YAIAPA
--
F
TW
RP
D
-
D
K
T
NF
T
F
LS
Y
-
FQN
E
------
P
E
T
G
YYGW
-
LP
KE
GT
V
-----
-E
P
L
--
PN
GK
--
RL
P
TDF
N
E
G
AK
N
NTYSRNEK
M
V
GY
S
F
D
H
E
F
N
DT
FTVR
Q
N
LR
F
A
E
N
K
--
-----
-
T
SQ
-------------------
NS
V
Y
G
Y
G
VC
S
D
PANAYSKQ
--------
CAALAPADKGH
Y
L
A
R
-
--
KY
------
VV
D
DE
K
L
QNF
S
V
D
TQ
L
QS
KF
AT
GDI
D
H
T
L
LT
G
V
----------
D
F
MR
MR
N
------------
D
I
NAW
F
G
YD
DS
V
P
LL
N
-
L
--
Y
N
P
-------------
VNTD
-
FD
FNAKDPANSGPYRI
L
N
KQ
K
Q
T
-
-
-
G
V
Y
VQ
D
QAQ
W
-
D
KVLVT
LG
G
R
-------
Y
DWAD
Q
-
ESLN
R
--------------
VAGTTD
-----
KR
DD
K
QF
----
T
W
RG
G
VNY
L
F
D
N
GVT
P
Y
F
SY
S
E
SF
E
P
---------
S
S
-
QV
G
KD
G
NI
-
F
A
P
S
K
G
KQ
YE
-------
V
G
V
K
YVPE
D
RP
IV
V
T
G
A
V
Y
N
L
T
K
T
N
NL
M
A
DP
-
E
G
S
F
F
SVEG
GE
I
R
--------
AR
GVE
I
E
AK
---
A
AL
S
A
SVN
V
VG
SYTY
T
DAE
YT
--
TDTTY
K
G
-
N
TP
AQV
P
-----
KHMASLW
A
D
Y
T
F
F
DG
P
L
SG
-
LT
L
G
-----
T
G
G
R
Y
TG
--
S
S
Y
---
GD
P
A
N
-
S
F
K
V
--
GSY
T
V
VD
ALV
RY
D
LARVGMA
GS
N
VALH
VNNLFD
RE
Y
V
AS
CF
--
NT
YG
CF
W
GA
E
R
Q
V
VA
T
A
T
F
R
F
fig|340184.6.peg.1479
Escherichia coli B7A (16-747/747)
IAV
V
V
A
T
A
V
-----
-
SG
MS
---
-
-----
-
---
V
Y
A
Q
A
A
V
E
P
KE-
D
T
IT
VTA
-
A
P
---
AP
Q
E
SAW
G
-
-
P
A
A
T
IAARQSAT
GTK
TDT
P
IQ
KV
PQS
IS
VV
T
A
E
E
M
A
L
H
Q
PK
SV
K
E
A
L
S
Y
TPGV
---
S
V
G
T
R
GAS
N
T
Y
D
HLI
I
RGF
-
AAEGQ
SQ
N
NY
L
--
-
N
G
L
K
-
LQGNF
Y
N
--
DA
VI
D
P
-
YM
L
ER
A
E
I
M
RGP
V
S
V
L
YG
KS
S
PGG
LL
NMV
S
KR
P
T
TEP
LKEV
-----
Q
--
FK
A
------
G
T
D
SL
FQ
T
GF
D
F
S
DS
L
DD
DG
VYS
Y
R
LT
G
LA
R
S
A
N
A
Q
QKGSE
E
Q
R
YAIAPA
--
F
TW
RP
D
-
D
K
T
NF
T
F
LS
Y
-
FQN
E
------
P
E
T
G
YYGW
-
LP
KE
GT
V
-----
-E
P
L
--
PN
GK
--
RL
P
TDF
N
E
G
AK
N
NTYSRNEK
M
V
GY
S
F
D
H
E
F
N
DT
FTVR
Q
N
LR
F
A
E
N
K
--
-----
-
T
SQ
-------------------
NS
V
Y
G
Y
G
VC
S
D
PANAYSKQ
--------
CAALAPADKGH
Y
L
A
R
-
--
KY
------
VV
D
DE
K
L
QNF
S
V
D
TQ
L
QS
KF
AT
GDI
D
H
T
L
LT
G
V
----------
D
F
MR
MR
N
------------
D
I
NAW
F
G
YD
DS
V
P
LL
N
-
L
--
Y
N
P
-------------
VNTD
-
FD
FNAKDPANSGPYRI
L
N
KQ
K
Q
T
-
-
-
G
V
Y
VQ
D
QAQ
W
-
D
KVLVT
LG
G
R
-------
Y
DWAD
Q
-
ESLN
R
--------------
VAGTTD
-----
KR
DD
K
QF
----
T
W
RG
G
VNY
L
F
D
N
GVT
P
Y
F
SY
S
E
SF
E
P
---------
S
S
-
QV
G
KD
G
NI
-
F
A
P
S
K
G
KQ
YE
-------
V
G
V
K
YVPE
D
RP
IV
V
T
G
A
V
Y
N
L
T
K
T
N
NL
M
A
DP
-
E
G
S
F
F
SVEG
GE
I
R
--------
AR
GVE
I
E
AK
---
A
AL
S
A
SVN
V
VG
SYTY
T
DAE
YT
--
TDTTY
K
G
-
N
TP
AQV
P
-----
KHMASLW
A
D
Y
T
F
F
DG
P
L
SG
-
LT
L
G
-----
T
G
G
R
Y
TG
--
S
S
Y
---
GD
P
A
N
-
S
F
K
V
--
GSY
T
V
VD
ALV
RY
D
LARVGMA
GS
N
VALH
VNNLFD
RE
Y
V
AS
CF
--
NT
YG
CF
W
GA
E
R
Q
V
VA
T
A
T
F
R
F
fig|595496.3.peg.156
Escherichia coli BW2952 (16-747/747)
IAV
V
V
A
T
A
V
-----
-
SG
MS
---
-
-----
-
---
V
Y
A
Q
A
A
V
E
P
KE-
D
T
IT
VTA
-
A
P
---
AP
Q
E
SAW
G
-
-
P
A
A
T
IAARQSAT
GTK
TDT
P
IQ
KV
PQS
IS
VV
T
A
E
E
M
A
L
H
Q
PK
SV
K
E
A
L
S
Y
TPGV
---
S
V
G
T
R
GAS
N
T
Y
D
HLI
I
RGF
-
AAEGQ
SQ
N
NY
L
--
-
N
G
L
K
-
LQGNF
Y
N
--
DA
VI
D
P
-
YM
L
ER
A
E
I
M
RGP
V
S
V
L
YG
KS
S
PGG
LL
NMV
S
KR
P
T
TEP
LKEV
-----
Q
--
FK
A
------
G
T
D
SL
FQ
T
GF
D
F
S
DS
L
DD
DG
VYS
Y
R
LT
G
LA
R
S
A
N
A
Q
QKGSE
E
Q
R
YAIAPA
--
F
TW
RP
D
-
D
K
T
NF
T
F
LS
Y
-
FQN
E
------
P
E
T
G
YYGW
-
LP
KE
GT
V
-----
-E
P
L
--
PN
GK
--
RL
P
TDF
N
E
G
AK
N
NTYSRNEK
M
V
GY
S
F
D
H
E
F
N
DT
FTVR
Q
N
LR
F
A
E
N
K
--
-----
-
T
SQ
-------------------
NS
V
Y
G
Y
G
VC
S
D
PANAYSKQ
--------
CAALAPADKGH
Y
L
A
R
-
--
KY
------
VV
D
DE
K
L
QNF
S
V
D
TQ
L
QS
KF
AT
GDI
D
H
T
L
LT
G
V
----------
D
F
MR
MR
N
------------
D
I
NAW
F
G
YD
DS
V
P
LL
N
-
L
--
Y
N
P
-------------
VNTD
-
FD
FNAKDPANSGPYRI
L
N
KQ
K
Q
T
-
-
-
G
V
Y
VQ
D
QAQ
W
-
D
KVLVT
LG
G
R
-------
Y
DWAD
Q
-
ESLN
R
--------------
VAGTTD
-----
KR
DD
K
QF
----
T
W
RG
G
VNY
L
F
D
N
GVT
P
Y
F
SY
S
E
SF
E
P
---------
S
S
-
QV
G
KD
G
NI
-
F
A
P
S
K
G
KQ
YE
-------
V
G
V
K
YVPE
D
RP
IV
V
T
G
A
V
Y
N
L
T
K
T
N
NL
M
A
DP
-
E
G
S
F
F
SVEG
GE
I
R
--------
AR
GVE
I
E
AK
---
A
AL
S
A
SVN
V
VG
SYTY
T
DAE
YT
--
TDTTY
K
G
-
N
TP
AQV
P
-----
KHMASLW
A
D
Y
T
F
F
DG
P
L
SG
-
LT
L
G
-----
T
G
G
R
Y
TG
--
S
S
Y
---
GD
P
A
N
-
S
F
K
V
--
GSY
T
V
VD
ALV
RY
D
LARVGMA
GS
N
VALH
VNNLFD
RE
Y
V
AS
CF
--
NT
YG
CF
W
GA
E
R
Q
V
VA
T
A
T
F
R
F
fig|536056.3.peg.3647
Escherichia coli DH1 (16-747/747)
IAV
V
V
A
T
A
V
-----
-
SG
MS
---
-
-----
-
---
V
Y
A
Q
A
A
V
E
P
KE-
D
T
IT
VTA
-
A
P
---
AP
Q
E
SAW
G
-
-
P
A
A
T
IAARQSAT
GTK
TDT
P
IQ
KV
PQS
IS
VV
T
A
E
E
M
A
L
H
Q
PK
SV
K
E
A
L
S
Y
TPGV
---
S
V
G
T
R
GAS
N
T
Y
D
HLI
I
RGF
-
AAEGQ
SQ
N
NY
L
--
-
N
G
L
K
-
LQGNF
Y
N
--
DA
VI
D
P
-
YM
L
ER
A
E
I
M
RGP
V
S
V
L
YG
KS
S
PGG
LL
NMV
S
KR
P
T
TEP
LKEV
-----
Q
--
FK
A
------
G
T
D
SL
FQ
T
GF
D
F
S
DS
L
DD
DG
VYS
Y
R
LT
G
LA
R
S
A
N
A
Q
QKGSE
E
Q
R
YAIAPA
--
F
TW
RP
D
-
D
K
T
NF
T
F
LS
Y
-
FQN
E
------
P
E
T
G
YYGW
-
LP
KE
GT
V
-----
-E
P
L
--
PN
GK
--
RL
P
TDF
N
E
G
AK
N
NTYSRNEK
M
V
GY
S
F
D
H
E
F
N
DT
FTVR
Q
N
LR
F
A
E
N
K
--
-----
-
T
SQ
-------------------
NS
V
Y
G
Y
G
VC
S
D
PANAYSKQ
--------
CAALAPADKGH
Y
L
A
R
-
--
KY
------
VV
D
DE
K
L
QNF
S
V
D
TQ
L
QS
KF
AT
GDI
D
H
T
L
LT
G
V
----------
D
F
MR
MR
N
------------
D
I
NAW
F
G
YD
DS
V
P
LL
N
-
L
--
Y
N
P
-------------
VNTD
-
FD
FNAKDPANSGPYRI
L
N
KQ
K
Q
T
-
-
-
G
V
Y
VQ
D
QAQ
W
-
D
KVLVT
LG
G
R
-------
Y
DWAD
Q
-
ESLN
R
--------------
VAGTTD
-----
KR
DD
K
QF
----
T
W
RG
G
VNY
L
F
D
N
GVT
P
Y
F
SY
S
E
SF
E
P
---------
S
S
-
QV
G
KD
G
NI
-
F
A
P
S
K
G
KQ
YE
-------
V
G
V
K
YVPE
D
RP
IV
V
T
G
A
V
Y
N
L
T
K
T
N
NL
M
A
DP
-
E
G
S
F
F
SVEG
GE
I
R
--------
AR
GVE
I
E
AK
---
A
AL
S
A
SVN
V
VG
SYTY
T
DAE
YT
--
TDTTY
K
G
-
N
TP
AQV
P
-----
KHMASLW
A
D
Y
T
F
F
DG
P
L
SG
-
LT
L
G
-----
T
G
G
R
Y
TG
--
S
S
Y
---
GD
P
A
N
-
S
F
K
V
--
GSY
T
V
VD
ALV
RY
D
LARVGMA
GS
N
VALH
VNNLFD
RE
Y
V
AS
CF
--
NT
YG
CF
W
GA
E
R
Q
V
VA
T
A
T
F
R
F
fig|340185.3.peg.1605
Escherichia coli E22 (16-747/747)
IAV
V
V
A
T
A
V
-----
-
SG
MS
---
-
-----
-
---
V
Y
A
Q
A
A
V
E
P
KE-
D
T
IT
VTA
-
A
P
---
AP
Q
E
SAW
G
-
-
P
A
A
T
IAARQSAT
GTK
TDT
P
IQ
KV
PQS
IS
VV
T
A
E
E
M
A
L
H
Q
PK
SV
K
E
A
L
S
Y
TPGV
---
S
V
G
T
R
GAS
N
T
Y
D
HLI
I
RGF
-
AAEGQ
SQ
N
NY
L
--
-
N
G
L
K
-
LQGNF
Y
N
--
DA
VI
D
P
-
YM
L
ER
A
E
I
M
RGP
V
S
V
L
YG
KS
S
PGG
LL
NMV
S
KR
P
T
TEP
LKEV
-----
Q
--
FK
A
------
G
T
D
SL
FQ
T
GF
D
F
S
DS
L
DD
DG
VYS
Y
R
LT
G
LA
R
S
A
N
A
Q
QKGSE
E
Q
R
YAIAPA
--
F
TW
RP
D
-
D
K
T
NF
T
F
LS
Y
-
FQN
E
------
P
E
T
G
YYGW
-
LP
KE
GT
V
-----
-E
P
L
--
PN
GK
--
RL
P
TDF
N
E
G
AK
N
NTYSRNEK
M
V
GY
S
F
D
H
E
F
N
DT
FTVR
Q
N
LR
F
A
E
N
K
--
-----
-
T
SQ
-------------------
NS
V
Y
G
Y
G
VC
S
D
PANAYSKQ
--------
CAALAPADKGH
Y
L
A
R
-
--
KY
------
VV
D
DE
K
L
QNF
S
V
D
TQ
L
QS
KF
AT
GDI
D
H
T
L
LT
G
V
----------
D
F
MR
MR
N
------------
D
I
NAW
F
G
YD
DS
V
P
LL
N
-
L
--
Y
N
P
-------------
VNTD
-
FD
FNAKDPANSGPYRI
L
N
KQ
K
Q
T
-
-
-
G
V
Y
VQ
D
QAQ
W
-
D
KVLVT
LG
G
R
-------
Y
DWAD
Q
-
ESLN
R
--------------
VAGTTD
-----
KR
DD
K
QF
----
T
W
RG
G
VNY
L
F
D
N
GVT
P
Y
F
SY
S
E
SF
E
P
---------
S
S
-
QV
G
KD
G
NI
-
F
A
P
S
K
G
KQ
YE
-------
V
G
V
K
YVPE
D
RP
IV
V
T
G
A
V
Y
N
L
T
K
T
N
NL
M
A
DP
-
E
G
S
F
F
SVEG
GE
I
R
--------
AR
GVE
I
E
AK
---
A
AL
S
A
SVN
V
VG
SYTY
T
DAE
YT
--
TDTTY
K
G
-
N
TP
AQV
P
-----
KHMASLW
A
D
Y
T
F
F
DG
P
L
SG
-
LT
L
G
-----
T
G
G
R
Y
TG
--
S
S
Y
---
GD
P
A
N
-
S
F
K
V
--
GSY
T
V
VD
ALV
RY
D
LARVGMA
GS
N
VALH
VNNLFD
RE
Y
V
AS
CF
--
NT
YG
CF
W
GA
E
R
Q
V
VA
T
A
T
F
R
F
fig|331111.3.peg.2722
Escherichia coli E24377A (16-747/747)
IAV
V
V
A
T
A
V
-----
-
SG
MS
---
-
-----
-
---
V
Y
A
Q
A
A
V
E
P
KE-
D
T
IT
VTA
-
A
P
---
AP
Q
E
SAW
G
-
-
P
A
A
T
IAARQSAT
GTK
TDT
P
IQ
KV
PQS
IS
VV
T
A
E
E
M
A
L
H
Q
PK
SV
K
E
A
L
S
Y
TPGV
---
S
V
G
T
R
GAS
N
T
Y
D
HLI
I
RGF
-
AAEGQ
SQ
N
NY
L
--
-
N
G
L
K
-
LQGNF
Y
N
--
DA
VI
D
P
-
YM
L
ER
A
E
I
M
RGP
V
S
V
L
YG
KS
S
PGG
LL
NMV
S
KR
P
T
TEP
LKEV
-----
Q
--
FK
A
------
G
T
D
SL
FQ
T
GF
D
F
S
DS
L
DD
DG
VYS
Y
R
LT
G
LA
R
S
A
N
A
Q
QKGSE
E
Q
R
YAIAPA
--
F
TW
RP
D
-
D
K
T
NF
T
F
LS
Y
-
FQN
E
------
P
E
T
G
YYGW
-
LP
KE
GT
V
-----
-E
P
L
--
PN
GK
--
RL
P
TDF
N
E
G
AK
N
NTYSRNEK
M
V
GY
S
F
D
H
E
F
N
DT
FTVR
Q
N
LR
F
A
E
N
K
--
-----
-
T
SQ
-------------------
NS
V
Y
G
Y
G
VC
S
D
PANAYSKQ
--------
CAALAPADKGH
Y
L
A
R
-
--
KY
------
VV
D
DE
K
L
QNF
S
V
D
TQ
L
QS
KF
AT
GDI
D
H
T
L
LT
G
V
----------
D
F
MR
MR
N
------------
D
I
NAW
F
G
YD
DS
V
P
LL
N
-
L
--
Y
N
P
-------------
VNTD
-
FD
FNAKDPANSGPYRI
L
N
KQ
K
Q
T
-
-
-
G
V
Y
VQ
D
QAQ
W
-
D
KVLVT
LG
G
R
-------
Y
DWAD
Q
-
ESLN
R
--------------
VAGTTD
-----
KR
DD
K
QF
----
T
W
RG
G
VNY
L
F
D
N
GVT
P
Y
F
SY
S
E
SF
E
P
---------
S
S
-
QV
G
KD
G
NI
-
F
A
P
S
K
G
KQ
YE
-------
V
G
V
K
YVPE
D
RP
IV
V
T
G
A
V
Y
N
L
T
K
T
N
NL
M
A
DP
-
E
G
S
F
F
SVEG
GE
I
R
--------
AR
GVE
I
E
AK
---
A
AL
S
A
SVN
V
VG
SYTY
T
DAE
YT
--
TDTTY
K
G
-
N
TP
AQV
P
-----
KHMASLW
A
D
Y
T
F
F
DG
P
L
SG
-
LT
L
G
-----
T
G
G
R
Y
TG
--
S
S
Y
---
GD
P
A
N
-
S
F
K
V
--
GSY
T
V
VD
ALV
RY
D
LARVGMA
GS
N
VALH
VNNLFD
RE
Y
V
AS
CF
--
NT
YG
CF
W
GA
E
R
Q
V
VA
T
A
T
F
R
F
fig|562.375.peg.2492
Escherichia coli EC4100B (16-747/747)
IAV
V
V
A
T
A
V
-----
-
SG
MS
---
-
-----
-
---
V
Y
A
Q
A
A
V
E
P
KE-
D
T
IT
VTA
-
A
P
---
AP
Q
E
SAW
G
-
-
P
A
A
T
IAARQSAT
GTK
TDT
P
IQ
KV
PQS
IS
VV
T
A
E
E
M
A
L
H
Q
PK
SV
K
E
A
L
S
Y
TPGV
---
S
V
G
T
R
GAS
N
T
Y
D
HLI
I
RGF
-
AAEGQ
SQ
N
NY
L
--
-
N
G
L
K
-
LQGNF
Y
N
--
DA
VI
D
P
-
YM
L
ER
A
E
I
M
RGP
V
S
V
L
YG
KS
S
PGG
LL
NMV
S
KR
P
T
TEP
LKEV
-----
Q
--
FK
A
------
G
T
D
SL
FQ
T
GF
D
F
S
DS
L
DD
DG
VYS
Y
R
LT
G
LA
R
S
A
N
A
Q
QKGSE
E
Q
R
YAIAPA
--
F
TW
RP
D
-
D
K
T
NF
T
F
LS
Y
-
FQN
E
------
P
E
T
G
YYGW
-
LP
KE
GT
V
-----
-E
P
L
--
PN
GK
--
RL
P
TDF
N
E
G
AK
N
NTYSRNEK
M
V
GY
S
F
D
H
E
F
N
DT
FTVR
Q
N
LR
F
A
E
N
K
--
-----
-
T
SQ
-------------------
NS
V
Y
G
Y
G
VC
S
D
PANAYSKQ
--------
CAALAPADKGH
Y
L
A
R
-
--
KY
------
VV
D
DE
K
L
QNF
S
V
D
TQ
L
QS
KF
AT
GDI
D
H
T
L
LT
G
V
----------
D
F
MR
MR
N
------------
D
I
NAW
F
G
YD
DS
V
P
LL
N
-
L
--
Y
N
P
-------------
VNTD
-
FD
FNAKDPANSGPYRI
L
N
KQ
K
Q
T
-
-
-
G
V
Y
VQ
D
QAQ
W
-
D
KVLVT
LG
G
R
-------
Y
DWAD
Q
-
ESLN
R
--------------
VAGTTD
-----
KR
DD
K
QF
----
T
W
RG
G
VNY
L
F
D
N
GVT
P
Y
F
SY
S
E
SF
E
P
---------
S
S
-
QV
G
KD
G
NI
-
F
A
P
S
K
G
KQ
YE
-------
V
G
V
K
YVPE
D
RP
IV
V
T
G
A
V
Y
N
L
T
K
T
N
NL
M
A
DP
-
E
G
S
F
F
SVEG
GE
I
R
--------
AR
GVE
I
E
AK
---
A
AL
S
A
SVN
V
VG
SYTY
T
DAE
YT
--
TDTTY
K
G
-
N
TP
AQV
P
-----
KHMASLW
A
D
Y
T
F
F
DG
P
L
SG
-
LT
L
G
-----
T
G
G
R
Y
TG
--
S
S
Y
---
GD
P
A
N
-
S
F
K
V
--
GSY
T
V
VD
ALV
RY
D
LARVGMA
GS
N
VALH
VNNLFD
RE
Y
V
AS
CF
--
NT
YG
CF
W
GA
E
R
Q
V
VA
T
A
T
F
R
F
fig|316401.4.peg.164
Escherichia coli ETEC H10407 (16-747/747)
IAV
V
V
A
T
A
V
-----
-
SG
MS
---
-
-----
-
---
V
Y
A
Q
A
A
V
E
P
KE-
D
T
IT
VTA
-
A
P
---
AP
Q
E
SAW
G
-
-
P
A
A
T
IAARQSAT
GTK
TDT
P
IQ
KV
PQS
IS
VV
T
A
E
E
M
A
L
H
Q
PK
SV
K
E
A
L
S
Y
TPGV
---
S
V
G
T
R
GAS
N
T
Y
D
HLI
I
RGF
-
AAEGQ
SQ
N
NY
L
--
-
N
G
L
K
-
LQGNF
Y
N
--
DA
VI
D
P
-
YM
L
ER
A
E
I
M
RGP
V
S
V
L
YG
KS
S
PGG
LL
NMV
S
KR
P
T
TEP
LKEV
-----
Q
--
FK
A
------
G
T
D
SL
FQ
T
GF
D
F
S
DS
L
DD
DG
VYS
Y
R
LT
G
LA
R
S
A
N
A
Q
QKGSE
E
Q
R
YAIAPA
--
F
TW
RP
D
-
D
K
T
NF
T
F
LS
Y
-
FQN
E
------
P
E
T
G
YYGW
-
LP
KE
GT
V
-----
-E
P
L
--
PN
GK
--
RL
P
TDF
N
E
G
AK
N
NTYSRNEK
M
V
GY
S
F
D
H
E
F
N
DT
FTVR
Q
N
LR
F
A
E
N
K
--
-----
-
T
SQ
-------------------
NS
V
Y
G
Y
G
VC
S
D
PANAYSKQ
--------
CAALAPADKGH
Y
L
A
R
-
--
KY
------
VV
D
DE
K
L
QNF
S
V
D
TQ
L
QS
KF
AT
GDI
D
H
T
L
LT
G
V
----------
D
F
MR
MR
N
------------
D
I
NAW
F
G
YD
DS
V
P
LL
N
-
L
--
Y
N
P
-------------
VNTD
-
FD
FNAKDPANSGPYRI
L
N
KQ
K
Q
T
-
-
-
G
V
Y
VQ
D
QAQ
W
-
D
KVLVT
LG
G
R
-------
Y
DWAD
Q
-
ESLN
R
--------------
VAGTTD
-----
KR
DD
K
QF
----
T
W
RG
G
VNY
L
F
D
N
GVT
P
Y
F
SY
S
E
SF
E
P
---------
S
S
-
QV
G
KD
G
NI
-
F
A
P
S
K
G
KQ
YE
-------
V
G
V
K
YVPE
D
RP
IV
V
T
G
A
V
Y
N
L
T
K
T
N
NL
M
A
DP
-
E
G
S
F
F
SVEG
GE
I
R
--------
AR
GVE
I
E
AK
---
A
AL
S
A
SVN
V
VG
SYTY
T
DAE
YT
--
TDTTY
K
G
-
N
TP
AQV
P
-----
KHMASLW
A
D
Y
T
F
F
DG
P
L
SG
-
LT
L
G
-----
T
G
G
R
Y
TG
--
S
S
Y
---
GD
P
A
N
-
S
F
K
V
--
GSY
T
V
VD
ALV
RY
D
LARVGMA
GS
N
VALH
VNNLFD
RE
Y
V
AS
CF
--
NT
YG
CF
W
GA
E
R
Q
V
VA
T
A
T
F
R
F
fig|656408.3.peg.5114
Escherichia coli H591 (16-747/747)
IAV
V
V
A
T
A
V
-----
-
SG
MS
---
-
-----
-
---
V
Y
A
Q
A
A
V
E
P
KE-
D
T
IT
VTA
-
A
P
---
AP
Q
E
SAW
G
-
-
P
A
A
T
IAARQSAT
GTK
TDT
P
IQ
KV
PQS
IS
VV
T
A
E
E
M
A
L
H
Q
PK
SV
K
E
A
L
S
Y
TPGV
---
S
V
G
T
R
GAS
N
T
Y
D
HLI
I
RGF
-
AAEGQ
SQ
N
NY
L
--
-
N
G
L
K
-
LQGNF
Y
N
--
DA
VI
D
P
-
YM
L
ER
A
E
I
M
RGP
V
S
V
L
YG
KS
S
PGG
LL
NMV
S
KR
P
T
TEP
LKEV
-----
Q
--
FK
A
------
G
T
D
SL
FQ
T
GF
D
F
S
DS
L
DD
DG
VYS
Y
R
LT
G
LA
R
S
A
N
A
Q
QKGSE
E
Q
R
YAIAPA
--
F
TW
RP
D
-
D
K
T
NF
T
F
LS
Y
-
FQN
E
------
P
E
T
G
YYGW
-
LP
KE
GT
V
-----
-E
P
L
--
PN
GK
--
RL
P
TDF
N
E
G
AK
N
NTYSRNEK
M
V
GY
S
F
D
H
E
F
N
DT
FTVR
Q
N
LR
F
A
E
N
K
--
-----
-
T
SQ
-------------------
NS
V
Y
G
Y
G
VC
S
D
PANAYSKQ
--------
CAALAPADKGH
Y
L
A
R
-
--
KY
------
VV
D
DE
K
L
QNF
S
V
D
TQ
L
QS
KF
AT
GDI
D
H
T
L
LT
G
V
----------
D
F
MR
MR
N
------------
D
I
NAW
F
G
YD
DS
V
P
LL
N
-
L
--
Y
N
P
-------------
VNTD
-
FD
FNAKDPANSGPYRI
L
N
KQ
K
Q
T
-
-
-
G
V
Y
VQ
D
QAQ
W
-
D
KVLVT
LG
G
R
-------
Y
DWAD
Q
-
ESLN
R
--------------
VAGTTD
-----
KR
DD
K
QF
----
T
W
RG
G
VNY
L
F
D
N
GVT
P
Y
F
SY
S
E
SF
E
P
---------
S
S
-
QV
G
KD
G
NI
-
F
A
P
S
K
G
KQ
YE
-------
V
G
V
K
YVPE
D
RP
IV
V
T
G
A
V
Y
N
L
T
K
T
N
NL
M
A
DP
-
E
G
S
F
F
SVEG
GE
I
R
--------
AR
GVE
I
E
AK
---
A
AL
S
A
SVN
V
VG
SYTY
T
DAE
YT
--
TDTTY
K
G
-
N
TP
AQV
P
-----
KHMASLW
A
D
Y
T
F
F
DG
P
L
SG
-
LT
L
G
-----
T
G
G
R
Y
TG
--
S
S
Y
---
GD
P
A
N
-
S
F
K
V
--
GSY
T
V
VD
ALV
RY
D
LARVGMA
GS
N
VALH
VNNLFD
RE
Y
V
AS
CF
--
NT
YG
CF
W
GA
E
R
Q
V
VA
T
A
T
F
R
F
fig|585034.4.peg.155
Escherichia coli IAI1 (16-747/747)
IAV
V
V
A
T
A
V
-----
-
SG
MS
---
-
-----
-
---
V
Y
A
Q
A
A
V
E
P
KE-
D
T
IT
VTA
-
A
P
---
AP
Q
E
SAW
G
-
-
P
A
A
T
IAARQSAT
GTK
TDT
P
IQ
KV
PQS
IS
VV
T
A
E
E
M
A
L
H
Q
PK
SV
K
E
A
L
S
Y
TPGV
---
S
V
G
T
R
GAS
N
T
Y
D
HLI
I
RGF
-
AAEGQ
SQ
N
NY
L
--
-
N
G
L
K
-
LQGNF
Y
N
--
DA
VI
D
P
-
YM
L
ER
A
E
I
M
RGP
V
S
V
L
YG
KS
S
PGG
LL
NMV
S
KR
P
T
TEP
LKEV
-----
Q
--
FK
A
------
G
T
D
SL
FQ
T
GF
D
F
S
DS
L
DD
DG
VYS
Y
R
LT
G
LA
R
S
A
N
A
Q
QKGSE
E
Q
R
YAIAPA
--
F
TW
RP
D
-
D
K
T
NF
T
F
LS
Y
-
FQN
E
------
P
E
T
G
YYGW
-
LP
KE
GT
V
-----
-E
P
L
--
PN
GK
--
RL
P
TDF
N
E
G
AK
N
NTYSRNEK
M
V
GY
S
F
D
H
E
F
N
DT
FTVR
Q
N
LR
F
A
E
N
K
--
-----
-
T
SQ
-------------------
NS
V
Y
G
Y
G
VC
S
D
PANAYSKQ
--------
CAALAPADKGH
Y
L
A
R
-
--
KY
------
VV
D
DE
K
L
QNF
S
V
D
TQ
L
QS
KF
AT
GDI
D
H
T
L
LT
G
V
----------
D
F
MR
MR
N
------------
D
I
NAW
F
G
YD
DS
V
P
LL
N
-
L
--
Y
N
P
-------------
VNTD
-
FD
FNAKDPANSGPYRI
L
N
KQ
K
Q
T
-
-
-
G
V
Y
VQ
D
QAQ
W
-
D
KVLVT
LG
G
R
-------
Y
DWAD
Q
-
ESLN
R
--------------
VAGTTD
-----
KR
DD
K
QF
----
T
W
RG
G
VNY
L
F
D
N
GVT
P
Y
F
SY
S
E
SF
E
P
---------
S
S
-
QV
G
KD
G
NI
-
F
A
P
S
K
G
KQ
YE
-------
V
G
V
K
YVPE
D
RP
IV
V
T
G
A
V
Y
N
L
T
K
T
N
NL
M
A
DP
-
E
G
S
F
F
SVEG
GE
I
R
--------
AR
GVE
I
E
AK
---
A
AL
S
A
SVN
V
VG
SYTY
T
DAE
YT
--
TDTTY
K
G
-
N
TP
AQV
P
-----
KHMASLW
A
D
Y
T
F
F
DG
P
L
SG
-
LT
L
G
-----
T
G
G
R
Y
TG
--
S
S
Y
---
GD
P
A
N
-
S
F
K
V
--
GSY
T
V
VD
ALV
RY
D
LARVGMA
GS
N
VALH
VNNLFD
RE
Y
V
AS
CF
--
NT
YG
CF
W
GA
E
R
Q
V
VA
T
A
T
F
R
F
fig|585034.5.peg.155
Escherichia coli IAI1 (16-747/747)
IAV
V
V
A
T
A
V
-----
-
SG
MS
---
-
-----
-
---
V
Y
A
Q
A
A
V
E
P
KE-
D
T
IT
VTA
-
A
P
---
AP
Q
E
SAW
G
-
-
P
A
A
T
IAARQSAT
GTK
TDT
P
IQ
KV
PQS
IS
VV
T
A
E
E
M
A
L
H
Q
PK
SV
K
E
A
L
S
Y
TPGV
---
S
V
G
T
R
GAS
N
T
Y
D
HLI
I
RGF
-
AAEGQ
SQ
N
NY
L
--
-
N
G
L
K
-
LQGNF
Y
N
--
DA
VI
D
P
-
YM
L
ER
A
E
I
M
RGP
V
S
V
L
YG
KS
S
PGG
LL
NMV
S
KR
P
T
TEP
LKEV
-----
Q
--
FK
A
------
G
T
D
SL
FQ
T
GF
D
F
S
DS
L
DD
DG
VYS
Y
R
LT
G
LA
R
S
A
N
A
Q
QKGSE
E
Q
R
YAIAPA
--
F
TW
RP
D
-
D
K
T
NF
T
F
LS
Y
-
FQN
E
------
P
E
T
G
YYGW
-
LP
KE
GT
V
-----
-E
P
L
--
PN
GK
--
RL
P
TDF
N
E
G
AK
N
NTYSRNEK
M
V
GY
S
F
D
H
E
F
N
DT
FTVR
Q
N
LR
F
A
E
N
K
--
-----
-
T
SQ
-------------------
NS
V
Y
G
Y
G
VC
S
D
PANAYSKQ
--------
CAALAPADKGH
Y
L
A
R
-
--
KY
------
VV
D
DE
K
L
QNF
S
V
D
TQ
L
QS
KF
AT
GDI
D
H
T
L
LT
G
V
----------
D
F
MR
MR
N
------------
D
I
NAW
F
G
YD
DS
V
P
LL
N
-
L
--
Y
N
P
-------------
VNTD
-
FD
FNAKDPANSGPYRI
L
N
KQ
K
Q
T
-
-
-
G
V
Y
VQ
D
QAQ
W
-
D
KVLVT
LG
G
R
-------
Y
DWAD
Q
-
ESLN
R
--------------
VAGTTD
-----
KR
DD
K
QF
----
T
W
RG
G
VNY
L
F
D
N
GVT
P
Y
F
SY
S
E
SF
E
P
---------
S
S
-
QV
G
KD
G
NI
-
F
A
P
S
K
G
KQ
YE
-------
V
G
V
K
YVPE
D
RP
IV
V
T
G
A
V
Y
N
L
T
K
T
N
NL
M
A
DP
-
E
G
S
F
F
SVEG
GE
I
R
--------
AR
GVE
I
E
AK
---
A
AL
S
A
SVN
V
VG
SYTY
T
DAE
YT
--
TDTTY
K
G
-
N
TP
AQV
P
-----
KHMASLW
A
D
Y
T
F
F
DG
P
L
SG
-
LT
L
G
-----
T
G
G
R
Y
TG
--
S
S
Y
---
GD
P
A
N
-
S
F
K
V
--
GSY
T
V
VD
ALV
RY
D
LARVGMA
GS
N
VALH
VNNLFD
RE
Y
V
AS
CF
--
NT
YG
CF
W
GA
E
R
Q
V
VA
T
A
T
F
R
F
fig|83333.1.peg.151
Escherichia coli K12 (16-747/747)
IAV
V
V
A
T
A
V
-----
-
SG
MS
---
-
-----
-
---
V
Y
A
Q
A
A
V
E
P
KE-
D
T
IT
VTA
-
A
P
---
AP
Q
E
SAW
G
-
-
P
A
A
T
IAARQSAT
GTK
TDT
P
IQ
KV
PQS
IS
VV
T
A
E
E
M
A
L
H
Q
PK
SV
K
E
A
L
S
Y
TPGV
---
S
V
G
T
R
GAS
N
T
Y
D
HLI
I
RGF
-
AAEGQ
SQ
N
NY
L
--
-
N
G
L
K
-
LQGNF
Y
N
--
DA
VI
D
P
-
YM
L
ER
A
E
I
M
RGP
V
S
V
L
YG
KS
S
PGG
LL
NMV
S
KR
P
T
TEP
LKEV
-----
Q
--
FK
A
------
G
T
D
SL
FQ
T
GF
D
F
S
DS
L
DD
DG
VYS
Y
R
LT
G
LA
R
S
A
N
A
Q
QKGSE
E
Q
R
YAIAPA
--
F
TW
RP
D
-
D
K
T
NF
T
F
LS
Y
-
FQN
E
------
P
E
T
G
YYGW
-
LP
KE
GT
V
-----
-E
P
L
--
PN
GK
--
RL
P
TDF
N
E
G
AK
N
NTYSRNEK
M
V
GY
S
F
D
H
E
F
N
DT
FTVR
Q
N
LR
F
A
E
N
K
--
-----
-
T
SQ
-------------------
NS
V
Y
G
Y
G
VC
S
D
PANAYSKQ
--------
CAALAPADKGH
Y
L
A
R
-
--
KY
------
VV
D
DE
K
L
QNF
S
V
D
TQ
L
QS
KF
AT
GDI
D
H
T
L
LT
G
V
----------
D
F
MR
MR
N
------------
D
I
NAW
F
G
YD
DS
V
P
LL
N
-
L
--
Y
N
P
-------------
VNTD
-
FD
FNAKDPANSGPYRI
L
N
KQ
K
Q
T
-
-
-
G
V
Y
VQ
D
QAQ
W
-
D
KVLVT
LG
G
R
-------
Y
DWAD
Q
-
ESLN
R
--------------
VAGTTD
-----
KR
DD
K
QF
----
T
W
RG
G
VNY
L
F
D
N
GVT
P
Y
F
SY
S
E
SF
E
P
---------
S
S
-
QV
G
KD
G
NI
-
F
A
P
S
K
G
KQ
YE
-------
V
G
V
K
YVPE
D
RP
IV
V
T
G
A
V
Y
N
L
T
K
T
N
NL
M
A
DP
-
E
G
S
F
F
SVEG
GE
I
R
--------
AR
GVE
I
E
AK
---
A
AL
S
A
SVN
V
VG
SYTY
T
DAE
YT
--
TDTTY
K
G
-
N
TP
AQV
P
-----
KHMASLW
A
D
Y
T
F
F
DG
P
L
SG
-
LT
L
G
-----
T
G
G
R
Y
TG
--
S
S
Y
---
GD
P
A
N
-
S
F
K
V
--
GSY
T
V
VD
ALV
RY
D
LARVGMA
GS
N
VALH
VNNLFD
RE
Y
V
AS
CF
--
NT
YG
CF
W
GA
E
R
Q
V
VA
T
A
T
F
R
F
fig|679207.4.peg.1198
Escherichia coli MS 107-1 (16-747/747)
IAV
V
V
A
T
A
V
-----
-
SG
MS
---
-
-----
-
---
V
Y
A
Q
A
A
V
E
P
KE-
D
T
IT
VTA
-
A
P
---
AP
Q
E
SAW
G
-
-
P
A
A
T
IAARQSAT
GTK
TDT
P
IQ
KV
PQS
IS
VV
T
A
E
E
M
A
L
H
Q
PK
SV
K
E
A
L
S
Y
TPGV
---
S
V
G
T
R
GAS
N
T
Y
D
HLI
I
RGF
-
AAEGQ
SQ
N
NY
L
--
-
N
G
L
K
-
LQGNF
Y
N
--
DA
VI
D
P
-
YM
L
ER
A
E
I
M
RGP
V
S
V
L
YG
KS
S
PGG
LL
NMV
S
KR
P
T
TEP
LKEV
-----
Q
--
FK
A
------
G
T
D
SL
FQ
T
GF
D
F
S
DS
L
DD
DG
VYS
Y
R
LT
G
LA
R
S
A
N
A
Q
QKGSE
E
Q
R
YAIAPA
--
F
TW
RP
D
-
D
K
T
NF
T
F
LS
Y
-
FQN
E
------
P
E
T
G
YYGW
-
LP
KE
GT
V
-----
-E
P
L
--
PN
GK
--
RL
P
TDF
N
E
G
AK
N
NTYSRNEK
M
V
GY
S
F
D
H
E
F
N
DT
FTVR
Q
N
LR
F
A
E
N
K
--
-----
-
T
SQ
-------------------
NS
V
Y
G
Y
G
VC
S
D
PANAYSKQ
--------
CAALAPADKGH
Y
L
A
R
-
--
KY
------
VV
D
DE
K
L
QNF
S
V
D
TQ
L
QS
KF
AT
GDI
D
H
T
L
LT
G
V
----------
D
F
MR
MR
N
------------
D
I
NAW
F
G
YD
DS
V
P
LL
N
-
L
--
Y
N
P
-------------
VNTD
-
FD
FNAKDPANSGPYRI
L
N
KQ
K
Q
T
-
-
-
G
V
Y
VQ
D
QAQ
W
-
D
KVLVT
LG
G
R
-------
Y
DWAD
Q
-
ESLN
R
--------------
VAGTTD
-----
KR
DD
K
QF
----
T
W
RG
G
VNY
L
F
D
N
GVT
P
Y
F
SY
S
E
SF
E
P
---------
S
S
-
QV
G
KD
G
NI
-
F
A
P
S
K
G
KQ
YE
-------
V
G
V
K
YVPE
D
RP
IV
V
T
G
A
V
Y
N
L
T
K
T
N
NL
M
A
DP
-
E
G
S
F
F
SVEG
GE
I
R
--------
AR
GVE
I
E
AK
---
A
AL
S
A
SVN
V
VG
SYTY
T
DAE
YT
--
TDTTY
K
G
-
N
TP
AQV
P
-----
KHMASLW
A
D
Y
T
F
F
DG
P
L
SG
-
LT
L
G
-----
T
G
G
R
Y
TG
--
S
S
Y
---
GD
P
A
N
-
S
F
K
V
--
GSY
T
V
VD
ALV
RY
D
LARVGMA
GS
N
VALH
VNNLFD
RE
Y
V
AS
CF
--
NT
YG
CF
W
GA
E
R
Q
V
VA
T
A
T
F
R
F
fig|679206.4.peg.3885
Escherichia coli MS 119-7 (16-747/747)
IAV
V
V
A
T
A
V
-----
-
SG
MS
---
-
-----
-
---
V
Y
A
Q
A
A
V
E
P
KE-
D
T
IT
VTA
-
A
P
---
AP
Q
E
SAW
G
-
-
P
A
A
T
IAARQSAT
GTK
TDT
P
IQ
KV
PQS
IS
VV
T
A
E
E
M
A
L
H
Q
PK
SV
K
E
A
L
S
Y
TPGV
---
S
V
G
T
R
GAS
N
T
Y
D
HLI
I
RGF
-
AAEGQ
SQ
N
NY
L
--
-
N
G
L
K
-
LQGNF
Y
N
--
DA
VI
D
P
-
YM
L
ER
A
E
I
M
RGP
V
S
V
L
YG
KS
S
PGG
LL
NMV
S
KR
P
T
TEP
LKEV
-----
Q
--
FK
A
------
G
T
D
SL
FQ
T
GF
D
F
S
DS
L
DD
DG
VYS
Y
R
LT
G
LA
R
S
A
N
A
Q
QKGSE
E
Q
R
YAIAPA
--
F
TW
RP
D
-
D
K
T
NF
T
F
LS
Y
-
FQN
E
------
P
E
T
G
YYGW
-
LP
KE
GT
V
-----
-E
P
L
--
PN
GK
--
RL
P
TDF
N
E
G
AK
N
NTYSRNEK
M
V
GY
S
F
D
H
E
F
N
DT
FTVR
Q
N
LR
F
A
E
N
K
--
-----
-
T
SQ
-------------------
NS
V
Y
G
Y
G
VC
S
D
PANAYSKQ
--------
CAALAPADKGH
Y
L
A
R
-
--
KY
------
VV
D
DE
K
L
QNF
S
V
D
TQ
L
QS
KF
AT
GDI
D
H
T
L
LT
G
V
----------
D
F
MR
MR
N
------------
D
I
NAW
F
G
YD
DS
V
P
LL
N
-
L
--
Y
N
P
-------------
VNTD
-
FD
FNAKDPANSGPYRI
L
N
KQ
K
Q
T
-
-
-
G
V
Y
VQ
D
QAQ
W
-
D
KVLVT
LG
G
R
-------
Y
DWAD
Q
-
ESLN
R
--------------
VAGTTD
-----
KR
DD
K
QF
----
T
W
RG
G
VNY
L
F
D
N
GVT
P
Y
F
SY
S
E
SF
E
P
---------
S
S
-
QV
G
KD
G
NI
-
F
A
P
S
K
G
KQ
YE
-------
V
G
V
K
YVPE
D
RP
IV
V
T
G
A
V
Y
N
L
T
K
T
N
NL
M
A
DP
-
E
G
S
F
F
SVEG
GE
I
R
--------
AR
GVE
I
E
AK
---
A
AL
S
A
SVN
V
VG
SYTY
T
DAE
YT
--
TDTTY
K
G
-
N
TP
AQV
P
-----
KHMASLW
A
D
Y
T
F
F
DG
P
L
SG
-
LT
L
G
-----
T
G
G
R
Y
TG
--
S
S
Y
---
GD
P
A
N
-
S
F
K
V
--
GSY
T
V
VD
ALV
RY
D
LARVGMA
GS
N
VALH
VNNLFD
RE
Y
V
AS
CF
--
NT
YG
CF
W
GA
E
R
Q
V
VA
T
A
T
F
R
F
fig|679204.3.peg.3452
Escherichia coli MS 145-7 (16-747/747)
IAV
V
V
A
T
A
V
-----
-
SG
MS
---
-
-----
-
---
V
Y
A
Q
A
A
V
E
P
KE-
D
T
IT
VTA
-
A
P
---
AP
Q
E
SAW
G
-
-
P
A
A
T
IAARQSAT
GTK
TDT
P
IQ
KV
PQS
IS
VV
T
A
E
E
M
A
L
H
Q
PK
SV
K
E
A
L
S
Y
TPGV
---
S
V
G
T
R
GAS
N
T
Y
D
HLI
I
RGF
-
AAEGQ
SQ
N
NY
L
--
-
N
G
L
K
-
LQGNF
Y
N
--
DA
VI
D
P
-
YM
L
ER
A
E
I
M
RGP
V
S
V
L
YG
KS
S
PGG
LL
NMV
S
KR
P
T
TEP
LKEV
-----
Q
--
FK
A
------
G
T
D
SL
FQ
T
GF
D
F
S
DS
L
DD
DG
VYS
Y
R
LT
G
LA
R
S
A
N
A
Q
QKGSE
E
Q
R
YAIAPA
--
F
TW
RP
D
-
D
K
T
NF
T
F
LS
Y
-
FQN
E
------
P
E
T
G
YYGW
-
LP
KE
GT
V
-----
-E
P
L
--
PN
GK
--
RL
P
TDF
N
E
G
AK
N
NTYSRNEK
M
V
GY
S
F
D
H
E
F
N
DT
FTVR
Q
N
LR
F
A
E
N
K
--
-----
-
T
SQ
-------------------
NS
V
Y
G
Y
G
VC
S
D
PANAYSKQ
--------
CAALAPADKGH
Y
L
A
R
-
--
KY
------
VV
D
DE
K
L
QNF
S
V
D
TQ
L
QS
KF
AT
GDI
D
H
T
L
LT
G
V
----------
D
F
MR
MR
N
------------
D
I
NAW
F
G
YD
DS
V
P
LL
N
-
L
--
Y
N
P
-------------
VNTD
-
FD
FNAKDPANSGPYRI
L
N
KQ
K
Q
T
-
-
-
G
V
Y
VQ
D
QAQ
W
-
D
KVLVT
LG
G
R
-------
Y
DWAD
Q
-
ESLN
R
--------------
VAGTTD
-----
KR
DD
K
QF
----
T
W
RG
G
VNY
L
F
D
N
GVT
P
Y
F
SY
S
E
SF
E
P
---------
S
S
-
QV
G
KD
G
NI
-
F
A
P
S
K
G
KQ
YE
-------
V
G
V
K
YVPE
D
RP
IV
V
T
G
A
V
Y
N
L
T
K
T
N
NL
M
A
DP
-
E
G
S
F
F
SVEG
GE
I
R
--------
AR
GVE
I
E
AK
---
A
AL
S
A
SVN
V
VG
SYTY
T
DAE
YT
--
TDTTY
K
G
-
N
TP
AQV
P
-----
KHMASLW
A
D
Y
T
F
F
DG
P
L
SG
-
LT
L
G
-----
T
G
G
R
Y
TG
--
S
S
Y
---
GD
P
A
N
-
S
F
K
V
--
GSY
T
V
VD
ALV
RY
D
LARVGMA
GS
N
VALH
VNNLFD
RE
Y
V
AS
CF
--
NT
YG
CF
W
GA
E
R
Q
V
VA
T
A
T
F
R
F
fig|749540.3.peg.2932
Escherichia coli MS 146-1 (16-747/747)
IAV
V
V
A
T
A
V
-----
-
SG
MS
---
-
-----
-
---
V
Y
A
Q
A
A
V
E
P
KE-
D
T
IT
VTA
-
A
P
---
AP
Q
E
SAW
G
-
-
P
A
A
T
IAARQSAT
GTK
TDT
P
IQ
KV
PQS
IS
VV
T
A
E
E
M
A
L
H
Q
PK
SV
K
E
A
L
S
Y
TPGV
---
S
V
G
T
R
GAS
N
T
Y
D
HLI
I
RGF
-
AAEGQ
SQ
N
NY
L
--
-
N
G
L
K
-
LQGNF
Y
N
--
DA
VI
D
P
-
YM
L
ER
A
E
I
M
RGP
V
S
V
L
YG
KS
S
PGG
LL
NMV
S
KR
P
T
TEP
LKEV
-----
Q
--
FK
A
------
G
T
D
SL
FQ
T
GF
D
F
S
DS
L
DD
DG
VYS
Y
R
LT
G
LA
R
S
A
N
A
Q
QKGSE
E
Q
R
YAIAPA
--
F
TW
RP
D
-
D
K
T
NF
T
F
LS
Y
-
FQN
E
------
P
E
T
G
YYGW
-
LP
KE
GT
V
-----
-E
P
L
--
PN
GK
--
RL
P
TDF
N
E
G
AK
N
NTYSRNEK
M
V
GY
S
F
D
H
E
F
N
DT
FTVR
Q
N
LR
F
A
E
N
K
--
-----
-
T
SQ
-------------------
NS
V
Y
G
Y
G
VC
S
D
PANAYSKQ
--------
CAALAPADKGH
Y
L
A
R
-
--
KY
------
VV
D
DE
K
L
QNF
S
V
D
TQ
L
QS
KF
AT
GDI
D
H
T
L
LT
G
V
----------
D
F
MR
MR
N
------------
D
I
NAW
F
G
YD
DS
V
P
LL
N
-
L
--
Y
N
P
-------------
VNTD
-
FD
FNAKDPANSGPYRI
L
N
KQ
K
Q
T
-
-
-
G
V
Y
VQ
D
QAQ
W
-
D
KVLVT
LG
G
R
-------
Y
DWAD
Q
-
ESLN
R
--------------
VAGTTD
-----
KR
DD
K
QF
----
T
W
RG
G
VNY
L
F
D
N
GVT
P
Y
F
SY
S
E
SF
E
P
---------
S
S
-
QV
G
KD
G
NI
-
F
A
P
S
K
G
KQ
YE
-------
V
G
V
K
YVPE
D
RP
IV
V
T
G
A
V
Y
N
L
T
K
T
N
NL
M
A
DP
-
E
G
S
F
F
SVEG
GE
I
R
--------
AR
GVE
I
E
AK
---
A
AL
S
A
SVN
V
VG
SYTY
T
DAE
YT
--
TDTTY
K
G
-
N
TP
AQV
P
-----
KHMASLW
A
D
Y
T
F
F
DG
P
L
SG
-
LT
L
G
-----
T
G
G
R
Y
TG
--
S
S
Y
---
GD
P
A
N
-
S
F
K
V
--
GSY
T
V
VD
ALV
RY
D
LARVGMA
GS
N
VALH
VNNLFD
RE
Y
V
AS
CF
--
NT
YG
CF
W
GA
E
R
Q
V
VA
T
A
T
F
R
F
fig|749545.3.peg.1211
Escherichia coli MS 182-1 (16-747/747)
IAV
V
V
A
T
A
V
-----
-
SG
MS
---
-
-----
-
---
V
Y
A
Q
A
A
V
E
P
KE-
D
T
IT
VTA
-
A
P
---
AP
Q
E
SAW
G
-
-
P
A
A
T
IAARQSAT
GTK
TDT
P
IQ
KV
PQS
IS
VV
T
A
E
E
M
A
L
H
Q
PK
SV
K
E
A
L
S
Y
TPGV
---
S
V
G
T
R
GAS
N
T
Y
D
HLI
I
RGF
-
AAEGQ
SQ
N
NY
L
--
-
N
G
L
K
-
LQGNF
Y
N
--
DA
VI
D
P
-
YM
L
ER
A
E
I
M
RGP
V
S
V
L
YG
KS
S
PGG
LL
NMV
S
KR
P
T
TEP
LKEV
-----
Q
--
FK
A
------
G
T
D
SL
FQ
T
GF
D
F
S
DS
L
DD
DG
VYS
Y
R
LT
G
LA
R
S
A
N
A
Q
QKGSE
E
Q
R
YAIAPA
--
F
TW
RP
D
-
D
K
T
NF
T
F
LS
Y
-
FQN
E
------
P
E
T
G
YYGW
-
LP
KE
GT
V
-----
-E
P
L
--
PN
GK
--
RL
P
TDF
N
E
G
AK
N
NTYSRNEK
M
V
GY
S
F
D
H
E
F
N
DT
FTVR
Q
N
LR
F
A
E
N
K
--
-----
-
T
SQ
-------------------
NS
V
Y
G
Y
G
VC
S
D
PANAYSKQ
--------
CAALAPADKGH
Y
L
A
R
-
--
KY
------
VV
D
DE
K
L
QNF
S
V
D
TQ
L
QS
KF
AT
GDI
D
H
T
L
LT
G
V
----------
D
F
MR
MR
N
------------
D
I
NAW
F
G
YD
DS
V
P
LL
N
-
L
--
Y
N
P
-------------
VNTD
-
FD
FNAKDPANSGPYRI
L
N
KQ
K
Q
T
-
-
-
G
V
Y
VQ
D
QAQ
W
-
D
KVLVT
LG
G
R
-------
Y
DWAD
Q
-
ESLN
R
--------------
VAGTTD
-----
KR
DD
K
QF
----
T
W
RG
G
VNY
L
F
D
N
GVT
P
Y
F
SY
S
E
SF
E
P
---------
S
S
-
QV
G
KD
G
NI
-
F
A
P
S
K
G
KQ
YE
-------
V
G
V
K
YVPE
D
RP
IV
V
T
G
A
V
Y
N
L
T
K
T
N
NL
M
A
DP
-
E
G
S
F
F
SVEG
GE
I
R
--------
AR
GVE
I
E
AK
---
A
AL
S
A
SVN
V
VG
SYTY
T
DAE
YT
--
TDTTY
K
G
-
N
TP
AQV
P
-----
KHMASLW
A
D
Y
T
F
F
DG
P
L
SG
-
LT
L
G
-----
T
G
G
R
Y
TG
--
S
S
Y
---
GD
P
A
N
-
S
F
K
V
--
GSY
T
V
VD
ALV
RY
D
LARVGMA
GS
N
VALH
VNNLFD
RE
Y
V
AS
CF
--
NT
YG
CF
W
GA
E
R
Q
V
VA
T
A
T
F
R
F
fig|585395.4.peg.154
Escherichia coli O103:H2 str. 12009 (16-747/747)
IAV
V
V
A
T
A
V
-----
-
SG
MS
---
-
-----
-
---
V
Y
A
Q
A
A
V
E
P
KE-
D
T
IT
VTA
-
A
P
---
AP
Q
E
SAW
G
-
-
P
A
A
T
IAARQSAT
GTK
TDT
P
IQ
KV
PQS
IS
VV
T
A
E
E
M
A
L
H
Q
PK
SV
K
E
A
L
S
Y
TPGV
---
S
V
G
T
R
GAS
N
T
Y
D
HLI
I
RGF
-
AAEGQ
SQ
N
NY
L
--
-
N
G
L
K
-
LQGNF
Y
N
--
DA
VI
D
P
-
YM
L
ER
A
E
I
M
RGP
V
S
V
L
YG
KS
S
PGG
LL
NMV
S
KR
P
T
TEP
LKEV
-----
Q
--
FK
A
------
G
T
D
SL
FQ
T
GF
D
F
S
DS
L
DD
DG
VYS
Y
R
LT
G
LA
R
S
A
N
A
Q
QKGSE
E
Q
R
YAIAPA
--
F
TW
RP
D
-
D
K
T
NF
T
F
LS
Y
-
FQN
E
------
P
E
T
G
YYGW
-
LP
KE
GT
V
-----
-E
P
L
--
PN
GK
--
RL
P
TDF
N
E
G
AK
N
NTYSRNEK
M
V
GY
S
F
D
H
E
F
N
DT
FTVR
Q
N
LR
F
A
E
N
K
--
-----
-
T
SQ
-------------------
NS
V
Y
G
Y
G
VC
S
D
PANAYSKQ
--------
CAALAPADKGH
Y
L
A
R
-
--
KY
------
VV
D
DE
K
L
QNF
S
V
D
TQ
L
QS
KF
AT
GDI
D
H
T
L
LT
G
V
----------
D
F
MR
MR
N
------------
D
I
NAW
F
G
YD
DS
V
P
LL
N
-
L
--
Y
N
P
-------------
VNTD
-
FD
FNAKDPANSGPYRI
L
N
KQ
K
Q
T
-
-
-
G
V
Y
VQ
D
QAQ
W
-
D
KVLVT
LG
G
R
-------
Y
DWAD
Q
-
ESLN
R
--------------
VAGTTD
-----
KR
DD
K
QF
----
T
W
RG
G
VNY
L
F
D
N
GVT
P
Y
F
SY
S
E
SF
E
P
---------
S
S
-
QV
G
KD
G
NI
-
F
A
P
S
K
G
KQ
YE
-------
V
G
V
K
YVPE
D
RP
IV
V
T
G
A
V
Y
N
L
T
K
T
N
NL
M
A
DP
-
E
G
S
F
F
SVEG
GE
I
R
--------
AR
GVE
I
E
AK
---
A
AL
S
A
SVN
V
VG
SYTY
T
DAE
YT
--
TDTTY
K
G
-
N
TP
AQV
P
-----
KHMASLW
A
D
Y
T
F
F
DG
P
L
SG
-
LT
L
G
-----
T
G
G
R
Y
TG
--
S
S
Y
---
GD
P
A
N
-
S
F
K
V
--
GSY
T
V
VD
ALV
RY
D
LARVGMA
GS
N
VALH
VNNLFD
RE
Y
V
AS
CF
--
NT
YG
CF
W
GA
E
R
Q
V
VA
T
A
T
F
R
F
fig|585396.4.peg.156
Escherichia coli O111:H- str. 11128 (16-747/747)
IAV
V
V
A
T
A
V
-----
-
SG
MS
---
-
-----
-
---
V
Y
A
Q
A
A
V
E
P
KE-
D
T
IT
VTA
-
A
P
---
AP
Q
E
SAW
G
-
-
P
A
A
T
IAARQSAT
GTK
TDT
P
IQ
KV
PQS
IS
VV
T
A
E
E
M
A
L
H
Q
PK
SV
K
E
A
L
S
Y
TPGV
---
S
V
G
T
R
GAS
N
T
Y
D
HLI
I
RGF
-
AAEGQ
SQ
N
NY
L
--
-
N
G
L
K
-
LQGNF
Y
N
--
DA
VI
D
P
-
YM
L
ER
A
E
I
M
RGP
V
S
V
L
YG
KS
S
PGG
LL
NMV
S
KR
P
T
TEP
LKEV
-----
Q
--
FK
A
------
G
T
D
SL
FQ
T
GF
D
F
S
DS
L
DD
DG
VYS
Y
R
LT
G
LA
R
S
A
N
A
Q
QKGSE
E
Q
R
YAIAPA
--
F
TW
RP
D
-
D
K
T
NF
T
F
LS
Y
-
FQN
E
------
P
E
T
G
YYGW
-
LP
KE
GT
V
-----
-E
P
L
--
PN
GK
--
RL
P
TDF
N
E
G
AK
N
NTYSRNEK
M
V
GY
S
F
D
H
E
F
N
DT
FTVR
Q
N
LR
F
A
E
N
K
--
-----
-
T
SQ
-------------------
NS
V
Y
G
Y
G
VC
S
D
PANAYSKQ
--------
CAALAPADKGH
Y
L
A
R
-
--
KY
------
VV
D
DE
K
L
QNF
S
V
D
TQ
L
QS
KF
AT
GDI
D
H
T
L
LT
G
V
----------
D
F
MR
MR
N
------------
D
I
NAW
F
G
YD
DS
V
P
LL
N
-
L
--
Y
N
P
-------------
VNTD
-
FD
FNAKDPANSGPYRI
L
N
KQ
K
Q
T
-
-
-
G
V
Y
VQ
D
QAQ
W
-
D
KVLVT
LG
G
R
-------
Y
DWAD
Q
-
ESLN
R
--------------
VAGTTD
-----
KR
DD
K
QF
----
T
W
RG
G
VNY
L
F
D
N
GVT
P
Y
F
SY
S
E
SF
E
P
---------
S
S
-
QV
G
KD
G
NI
-
F
A
P
S
K
G
KQ
YE
-------
V
G
V
K
YVPE
D
RP
IV
V
T
G
A
V
Y
N
L
T
K
T
N
NL
M
A
DP
-
E
G
S
F
F
SVEG
GE
I
R
--------
AR
GVE
I
E
AK
---
A
AL
S
A
SVN
V
VG
SYTY
T
DAE
YT
--
TDTTY
K
G
-
N
TP
AQV
P
-----
KHMASLW
A
D
Y
T
F
F
DG
P
L
SG
-
LT
L
G
-----
T
G
G
R
Y
TG
--
S
S
Y
---
GD
P
A
N
-
S
F
K
V
--
GSY
T
V
VD
ALV
RY
D
LARVGMA
GS
N
VALH
VNNLFD
RE
Y
V
AS
CF
--
NT
YG
CF
W
GA
E
R
Q
V
VA
T
A
T
F
R
F
fig|656443.3.peg.295
Escherichia coli TA271 (16-747/747)
IAV
V
V
A
T
A
V
-----
-
SG
MS
---
-
-----
-
---
V
Y
A
Q
A
A
V
E
P
KE-
D
T
IT
VTA
-
A
P
---
AP
Q
E
SAW
G
-
-
P
A
A
T
IAARQSAT
GTK
TDT
P
IQ
KV
PQS
IS
VV
T
A
E
E
M
A
L
H
Q
PK
SV
K
E
A
L
S
Y
TPGV
---
S
V
G
T
R
GAS
N
T
Y
D
HLI
I
RGF
-
AAEGQ
SQ
N
NY
L
--
-
N
G
L
K
-
LQGNF
Y
N
--
DA
VI
D
P
-
YM
L
ER
A
E
I
M
RGP
V
S
V
L
YG
KS
S
PGG
LL
NMV
S
KR
P
T
TEP
LKEV
-----
Q
--
FK
A
------
G
T
D
SL
FQ
T
GF
D
F
S
DS
L
DD
DG
VYS
Y
R
LT
G
LA
R
S
A
N
A
Q
QKGSE
E
Q
R
YAIAPA
--
F
TW
RP
D
-
D
K
T
NF
T
F
LS
Y
-
FQN
E
------
P
E
T
G
YYGW
-
LP
KE
GT
V
-----
-E
P
L
--
PN
GK
--
RL
P
TDF
N
E
G
AK
N
NTYSRNEK
M
V
GY
S
F
D
H
E
F
N
DT
FTVR
Q
N
LR
F
A
E
N
K
--
-----
-
T
SQ
-------------------
NS
V
Y
G
Y
G
VC
S
D
PANAYSKQ
--------
CAALAPADKGH
Y
L
A
R
-
--
KY
------
VV
D
DE
K
L
QNF
S
V
D
TQ
L
QS
KF
AT
GDI
D
H
T
L
LT
G
V
----------
D
F
MR
MR
N
------------
D
I
NAW
F
G
YD
DS
V
P
LL
N
-
L
--
Y
N
P
-------------
VNTD
-
FD
FNAKDPANSGPYRI
L
N
KQ
K
Q
T
-
-
-
G
V
Y
VQ
D
QAQ
W
-
D
KVLVT
LG
G
R
-------
Y
DWAD
Q
-
ESLN
R
--------------
VAGTTD
-----
KR
DD
K
QF
----
T
W
RG
G
VNY
L
F
D
N
GVT
P
Y
F
SY
S
E
SF
E
P
---------
S
S
-
QV
G
KD
G
NI
-
F
A
P
S
K
G
KQ
YE
-------
V
G
V
K
YVPE
D
RP
IV
V
T
G
A
V
Y
N
L
T
K
T
N
NL
M
A
DP
-
E
G
S
F
F
SVEG
GE
I
R
--------
AR
GVE
I
E
AK
---
A
AL
S
A
SVN
V
VG
SYTY
T
DAE
YT
--
TDTTY
K
G
-
N
TP
AQV
P
-----
KHMASLW
A
D
Y
T
F
F
DG
P
L
SG
-
LT
L
G
-----
T
G
G
R
Y
TG
--
S
S
Y
---
GD
P
A
N
-
S
F
K
V
--
GSY
T
V
VD
ALV
RY
D
LARVGMA
GS
N
VALH
VNNLFD
RE
Y
V
AS
CF
--
NT
YG
CF
W
GA
E
R
Q
V
VA
T
A
T
F
R
F
fig|316407.3.peg.147
Escherichia coli W3110 (16-747/747)
IAV
V
V
A
T
A
V
-----
-
SG
MS
---
-
-----
-
---
V
Y
A
Q
A
A
V
E
P
KE-
D
T
IT
VTA
-
A
P
---
AP
Q
E
SAW
G
-
-
P
A
A
T
IAARQSAT
GTK
TDT
P
IQ
KV
PQS
IS
VV
T
A
E
E
M
A
L
H
Q
PK
SV
K
E
A
L
S
Y
TPGV
---
S
V
G
T
R
GAS
N
T
Y
D
HLI
I
RGF
-
AAEGQ
SQ
N
NY
L
--
-
N
G
L
K
-
LQGNF
Y
N
--
DA
VI
D
P
-
YM
L
ER
A
E
I
M
RGP
V
S
V
L
YG
KS
S
PGG
LL
NMV
S
KR
P
T
TEP
LKEV
-----
Q
--
FK
A
------
G
T
D
SL
FQ
T
GF
D
F
S
DS
L
DD
DG
VYS
Y
R
LT
G
LA
R
S
A
N
A
Q
QKGSE
E
Q
R
YAIAPA
--
F
TW
RP
D
-
D
K
T
NF
T
F
LS
Y
-
FQN
E
------
P
E
T
G
YYGW
-
LP
KE
GT
V
-----
-E
P
L
--
PN
GK
--
RL
P
TDF
N
E
G
AK
N
NTYSRNEK
M
V
GY
S
F
D
H
E
F
N
DT
FTVR
Q
N
LR
F
A
E
N
K
--
-----
-
T
SQ
-------------------
NS
V
Y
G
Y
G
VC
S
D
PANAYSKQ
--------
CAALAPADKGH
Y
L
A
R
-
--
KY
------
VV
D
DE
K
L
QNF
S
V
D
TQ
L
QS
KF
AT
GDI
D
H
T
L
LT
G
V
----------
D
F
MR
MR
N
------------
D
I
NAW
F
G
YD
DS
V
P
LL
N
-
L
--
Y
N
P
-------------
VNTD
-
FD
FNAKDPANSGPYRI
L
N
KQ
K
Q
T
-
-
-
G
V
Y
VQ
D
QAQ
W
-
D
KVLVT
LG
G
R
-------
Y
DWAD
Q
-
ESLN
R
--------------
VAGTTD
-----
KR
DD
K
QF
----
T
W
RG
G
VNY
L
F
D
N
GVT
P
Y
F
SY
S
E
SF
E
P
---------
S
S
-
QV
G
KD
G
NI
-
F
A
P
S
K
G
KQ
YE
-------
V
G
V
K
YVPE
D
RP
IV
V
T
G
A
V
Y
N
L
T
K
T
N
NL
M
A
DP
-
E
G
S
F
F
SVEG
GE
I
R
--------
AR
GVE
I
E
AK
---
A
AL
S
A
SVN
V
VG
SYTY
T
DAE
YT
--
TDTTY
K
G
-
N
TP
AQV
P
-----
KHMASLW
A
D
Y
T
F
F
DG
P
L
SG
-
LT
L
G
-----
T
G
G
R
Y
TG
--
S
S
Y
---
GD
P
A
N
-
S
F
K
V
--
GSY
T
V
VD
ALV
RY
D
LARVGMA
GS
N
VALH
VNNLFD
RE
Y
V
AS
CF
--
NT
YG
CF
W
GA
E
R
Q
V
VA
T
A
T
F
R
F
fig|511145.12.peg.156
Escherichia coli str. K-12 substr. MG1655 (16-747/747)
IAV
V
V
A
T
A
V
-----
-
SG
MS
---
-
-----
-
---
V
Y
A
Q
A
A
V
E
P
KE-
D
T
IT
VTA
-
A
P
---
AP
Q
E
SAW
G
-
-
P
A
A
T
IAARQSAT
GTK
TDT
P
IQ
KV
PQS
IS
VV
T
A
E
E
M
A
L
H
Q
PK
SV
K
E
A
L
S
Y
TPGV
---
S
V
G
T
R
GAS
N
T
Y
D
HLI
I
RGF
-
AAEGQ
SQ
N
NY
L
--
-
N
G
L
K
-
LQGNF
Y
N
--
DA
VI
D
P
-
YM
L
ER
A
E
I
M
RGP
V
S
V
L
YG
KS
S
PGG
LL
NMV
S
KR
P
T
TEP
LKEV
-----
Q
--
FK
A
------
G
T
D
SL
FQ
T
GF
D
F
S
DS
L
DD
DG
VYS
Y
R
LT
G
LA
R
S
A
N
A
Q
QKGSE
E
Q
R
YAIAPA
--
F
TW
RP
D
-
D
K
T
NF
T
F
LS
Y
-
FQN
E
------
P
E
T
G
YYGW
-
LP
KE
GT
V
-----
-E
P
L
--
PN
GK
--
RL
P
TDF
N
E
G
AK
N
NTYSRNEK
M
V
GY
S
F
D
H
E
F
N
DT
FTVR
Q
N
LR
F
A
E
N
K
--
-----
-
T
SQ
-------------------
NS
V
Y
G
Y
G
VC
S
D
PANAYSKQ
--------
CAALAPADKGH
Y
L
A
R
-
--
KY
------
VV
D
DE
K
L
QNF
S
V
D
TQ
L
QS
KF
AT
GDI
D
H
T
L
LT
G
V
----------
D
F
MR
MR
N
------------
D
I
NAW
F
G
YD
DS
V
P
LL
N
-
L
--
Y
N
P
-------------
VNTD
-
FD
FNAKDPANSGPYRI
L
N
KQ
K
Q
T
-
-
-
G
V
Y
VQ
D
QAQ
W
-
D
KVLVT
LG
G
R
-------
Y
DWAD
Q
-
ESLN
R
--------------
VAGTTD
-----
KR
DD
K
QF
----
T
W
RG
G
VNY
L
F
D
N
GVT
P
Y
F
SY
S
E
SF
E
P
---------
S
S
-
QV
G
KD
G
NI
-
F
A
P
S
K
G
KQ
YE
-------
V
G
V
K
YVPE
D
RP
IV
V
T
G
A
V
Y
N
L
T
K
T
N
NL
M
A
DP
-
E
G
S
F
F
SVEG
GE
I
R
--------
AR
GVE
I
E
AK
---
A
AL
S
A
SVN
V
VG
SYTY
T
DAE
YT
--
TDTTY
K
G
-
N
TP
AQV
P
-----
KHMASLW
A
D
Y
T
F
F
DG
P
L
SG
-
LT
L
G
-----
T
G
G
R
Y
TG
--
S
S
Y
---
GD
P
A
N
-
S
F
K
V
--
GSY
T
V
VD
ALV
RY
D
LARVGMA
GS
N
VALH
VNNLFD
RE
Y
V
AS
CF
--
NT
YG
CF
W
GA
E
R
Q
V
VA
T
A
T
F
R
F
fig|511145.6.peg.155
Escherichia coli str. K-12 substr. MG1655 (16-747/747)
IAV
V
V
A
T
A
V
-----
-
SG
MS
---
-
-----
-
---
V
Y
A
Q
A
A
V
E
P
KE-
D
T
IT
VTA
-
A
P
---
AP
Q
E
SAW
G
-
-
P
A
A
T
IAARQSAT
GTK
TDT
P
IQ
KV
PQS
IS
VV
T
A
E
E
M
A
L
H
Q
PK
SV
K
E
A
L
S
Y
TPGV
---
S
V
G
T
R
GAS
N
T
Y
D
HLI
I
RGF
-
AAEGQ
SQ
N
NY
L
--
-
N
G
L
K
-
LQGNF
Y
N
--
DA
VI
D
P
-
YM
L
ER
A
E
I
M
RGP
V
S
V
L
YG
KS
S
PGG
LL
NMV
S
KR
P
T
TEP
LKEV
-----
Q
--
FK
A
------
G
T
D
SL
FQ
T
GF
D
F
S
DS
L
DD
DG
VYS
Y
R
LT
G
LA
R
S
A
N
A
Q
QKGSE
E
Q
R
YAIAPA
--
F
TW
RP
D
-
D
K
T
NF
T
F
LS
Y
-
FQN
E
------
P
E
T
G
YYGW
-
LP
KE
GT
V
-----
-E
P
L
--
PN
GK
--
RL
P
TDF
N
E
G
AK
N
NTYSRNEK
M
V
GY
S
F
D
H
E
F
N
DT
FTVR
Q
N
LR
F
A
E
N
K
--
-----
-
T
SQ
-------------------
NS
V
Y
G
Y
G
VC
S
D
PANAYSKQ
--------
CAALAPADKGH
Y
L
A
R
-
--
KY
------
VV
D
DE
K
L
QNF
S
V
D
TQ
L
QS
KF
AT
GDI
D
H
T
L
LT
G
V
----------
D
F
MR
MR
N
------------
D
I
NAW
F
G
YD
DS
V
P
LL
N
-
L
--
Y
N
P
-------------
VNTD
-
FD
FNAKDPANSGPYRI
L
N
KQ
K
Q
T
-
-
-
G
V
Y
VQ
D
QAQ
W
-
D
KVLVT
LG
G
R
-------
Y
DWAD
Q
-
ESLN
R
--------------
VAGTTD
-----
KR
DD
K
QF
----
T
W
RG
G
VNY
L
F
D
N
GVT
P
Y
F
SY
S
E
SF
E
P
---------
S
S
-
QV
G
KD
G
NI
-
F
A
P
S
K
G
KQ
YE
-------
V
G
V
K
YVPE
D
RP
IV
V
T
G
A
V
Y
N
L
T
K
T
N
NL
M
A
DP
-
E
G
S
F
F
SVEG
GE
I
R
--------
AR
GVE
I
E
AK
---
A
AL
S
A
SVN
V
VG
SYTY
T
DAE
YT
--
TDTTY
K
G
-
N
TP
AQV
P
-----
KHMASLW
A
D
Y
T
F
F
DG
P
L
SG
-
LT
L
G
-----
T
G
G
R
Y
TG
--
S
S
Y
---
GD
P
A
N
-
S
F
K
V
--
GSY
T
V
VD
ALV
RY
D
LARVGMA
GS
N
VALH
VNNLFD
RE
Y
V
AS
CF
--
NT
YG
CF
W
GA
E
R
Q
V
VA
T
A
T
F
R
F
fig|595495.4.peg.3974
Escherichia coli KO11 (16-747/747)
IAV
V
V
A
T
A
V
-----
-
SG
MS
---
-
-----
-
---
V
Y
A
Q
A
A
V
E
P
KE-
D
T
IT
VTA
-
A
P
---
AP
Q
E
SAW
G
-
-
P
A
A
T
IAARQSAT
GTK
TDT
P
IQ
KV
PQS
IS
VV
T
A
E
E
M
A
L
H
Q
PK
SV
K
E
A
L
S
Y
TPGV
---
S
V
G
T
R
GAS
N
T
Y
D
HLI
I
RGF
-
AAEGQ
SQ
N
NY
L
--
-
N
G
L
K
-
LQGNF
Y
N
--
DA
VI
D
P
-
YM
L
ER
A
E
I
M
RGP
V
S
V
L
YG
KS
S
PGG
LL
NMV
S
KR
P
T
TEP
M
KEV
-----
Q
--
FK
A
------
G
T
D
SL
FQ
T
GF
D
F
S
DS
L
DD
DG
VYS
Y
R
LT
G
LA
R
S
A
N
A
Q
QKGSE
E
Q
R
YAIAPA
--
F
TW
RP
D
-
D
K
T
NF
T
F
LS
Y
-
FQN
E
------
P
E
T
G
YYGW
-
LP
KE
GT
V
-----
-E
P
L
--
PN
GK
--
RL
P
TDF
N
E
G
AK
N
NTYSRNEK
M
V
GY
S
F
D
H
E
F
N
DT
FTVR
Q
N
LR
F
A
E
N
K
--
-----
-
T
SQ
-------------------
NS
V
Y
G
Y
G
VC
S
D
PANAYSKQ
--------
CAALAPADKGH
Y
L
A
R
-
--
KY
------
VV
D
DE
K
L
QNF
S
V
D
TQ
L
QS
KF
AT
GDI
D
H
T
L
LT
G
V
----------
D
F
MR
MR
N
------------
D
I
NAW
F
G
YD
DS
V
P
LL
N
-
L
--
Y
N
P
-------------
VNTD
-
FD
FNAKDPANSGPYRI
L
N
KQ
K
Q
T
-
-
-
G
V
Y
VQ
D
QAQ
W
-
D
KVLVT
LG
G
R
-------
Y
DWAD
Q
-
ESLN
R
--------------
VAGTTD
-----
KR
DD
K
QF
----
T
W
RG
G
VNY
L
F
D
N
GVT
P
Y
F
SY
S
E
SF
E
P
---------
S
S
-
QV
G
KD
G
NI
-
F
A
P
S
K
G
KQ
YE
-------
V
G
V
K
YVPE
D
RP
IV
V
T
G
A
V
Y
N
L
T
K
T
N
NL
M
A
DP
-
E
G
S
F
F
SVEG
GE
I
R
--------
AR
GVE
I
E
AK
---
A
AL
S
A
SVN
V
VG
SYTY
T
DAE
YT
--
TDTTY
K
G
-
N
TP
AQV
P
-----
KHMASLW
A
D
Y
T
F
F
DG
P
L
SG
-
LT
L
G
-----
T
G
G
R
Y
TG
--
S
S
Y
---
GD
P
A
N
-
S
F
K
V
--
GSY
T
V
VD
ALV
RY
D
LARVGMA
GS
N
VALH
VNNLFD
RE
Y
V
AS
CF
--
NT
YG
CF
W
GA
E
R
Q
V
VA
T
A
T
F
R
F
fig|566546.3.peg.1573
Escherichia coli W (16-747/747)
IAV
V
V
A
T
A
V
-----
-
SG
MS
---
-
-----
-
---
V
Y
A
Q
A
A
V
E
P
KE-
D
T
IT
VTA
-
A
P
---
AP
Q
E
SAW
G
-
-
P
A
A
T
IAARQSAT
GTK
TDT
P
IQ
KV
PQS
IS
VV
T
A
E
E
M
A
L
H
Q
PK
SV
K
E
A
L
S
Y
TPGV
---
S
V
G
T
R
GAS
N
T
Y
D
HLI
I
RGF
-
AAEGQ
SQ
N
NY
L
--
-
N
G
L
K
-
LQGNF
Y
N
--
DA
VI
D
P
-
YM
L
ER
A
E
I
M
RGP
V
S
V
L
YG
KS
S
PGG
LL
NMV
S
KR
P
T
TEP
M
KEV
-----
Q
--
FK
A
------
G
T
D
SL
FQ
T
GF
D
F
S
DS
L
DD
DG
VYS
Y
R
LT
G
LA
R
S
A
N
A
Q
QKGSE
E
Q
R
YAIAPA
--
F
TW
RP
D
-
D
K
T
NF
T
F
LS
Y
-
FQN
E
------
P
E
T
G
YYGW
-
LP
KE
GT
V
-----
-E
P
L
--
PN
GK
--
RL
P
TDF
N
E
G
AK
N
NTYSRNEK
M
V
GY
S
F
D
H
E
F
N
DT
FTVR
Q
N
LR
F
A
E
N
K
--
-----
-
T
SQ
-------------------
NS
V
Y
G
Y
G
VC
S
D
PANAYSKQ
--------
CAALAPADKGH
Y
L
A
R
-
--
KY
------
VV
D
DE
K
L
QNF
S
V
D
TQ
L
QS
KF
AT
GDI
D
H
T
L
LT
G
V
----------
D
F
MR
MR
N
------------
D
I
NAW
F
G
YD
DS
V
P
LL
N
-
L
--
Y
N
P
-------------
VNTD
-
FD
FNAKDPANSGPYRI
L
N
KQ
K
Q
T
-
-
-
G
V
Y
VQ
D
QAQ
W
-
D
KVLVT
LG
G
R
-------
Y
DWAD
Q
-
ESLN
R
--------------
VAGTTD
-----
KR
DD
K
QF
----
T
W
RG
G
VNY
L
F
D
N
GVT
P
Y
F
SY
S
E
SF
E
P
---------
S
S
-
QV
G
KD
G
NI
-
F
A
P
S
K
G
KQ
YE
-------
V
G
V
K
YVPE
D
RP
IV
V
T
G
A
V
Y
N
L
T
K
T
N
NL
M
A
DP
-
E
G
S
F
F
SVEG
GE
I
R
--------
AR
GVE
I
E
AK
---
A
AL
S
A
SVN
V
VG
SYTY
T
DAE
YT
--
TDTTY
K
G
-
N
TP
AQV
P
-----
KHMASLW
A
D
Y
T
F
F
DG
P
L
SG
-
LT
L
G
-----
T
G
G
R
Y
TG
--
S
S
Y
---
GD
P
A
N
-
S
F
K
V
--
GSY
T
V
VD
ALV
RY
D
LARVGMA
GS
N
VALH
VNNLFD
RE
Y
V
AS
CF
--
NT
YG
CF
W
GA
E
R
Q
V
VA
T
A
T
F
R
F
fig|566546.4.peg.150
Escherichia coli W (16-747/747)
IAV
V
V
A
T
A
V
-----
-
SG
MS
---
-
-----
-
---
V
Y
A
Q
A
A
V
E
P
KE-
D
T
IT
VTA
-
A
P
---
AP
Q
E
SAW
G
-
-
P
A
A
T
IAARQSAT
GTK
TDT
P
IQ
KV
PQS
IS
VV
T
A
E
E
M
A
L
H
Q
PK
SV
K
E
A
L
S
Y
TPGV
---
S
V
G
T
R
GAS
N
T
Y
D
HLI
I
RGF
-
AAEGQ
SQ
N
NY
L
--
-
N
G
L
K
-
LQGNF
Y
N
--
DA
VI
D
P
-
YM
L
ER
A
E
I
M
RGP
V
S
V
L
YG
KS
S
PGG
LL
NMV
S
KR
P
T
TEP
M
KEV
-----
Q
--
FK
A
------
G
T
D
SL
FQ
T
GF
D
F
S
DS
L
DD
DG
VYS
Y
R
LT
G
LA
R
S
A
N
A
Q
QKGSE
E
Q
R
YAIAPA
--
F
TW
RP
D
-
D
K
T
NF
T
F
LS
Y
-
FQN
E
------
P
E
T
G
YYGW
-
LP
KE
GT
V
-----
-E
P
L
--
PN
GK
--
RL
P
TDF
N
E
G
AK
N
NTYSRNEK
M
V
GY
S
F
D
H
E
F
N
DT
FTVR
Q
N
LR
F
A
E
N
K
--
-----
-
T
SQ
-------------------
NS
V
Y
G
Y
G
VC
S
D
PANAYSKQ
--------
CAALAPADKGH
Y
L
A
R
-
--
KY
------
VV
D
DE
K
L
QNF
S
V
D
TQ
L
QS
KF
AT
GDI
D
H
T
L
LT
G
V
----------
D
F
MR
MR
N
------------
D
I
NAW
F
G
YD
DS
V
P
LL
N
-
L
--
Y
N
P
-------------
VNTD
-
FD
FNAKDPANSGPYRI
L
N
KQ
K
Q
T
-
-
-
G
V
Y
VQ
D
QAQ
W
-
D
KVLVT
LG
G
R
-------
Y
DWAD
Q
-
ESLN
R
--------------
VAGTTD
-----
KR
DD
K
QF
----
T
W
RG
G
VNY
L
F
D
N
GVT
P
Y
F
SY
S
E
SF
E
P
---------
S
S
-
QV
G
KD
G
NI
-
F
A
P
S
K
G
KQ
YE
-------
V
G
V
K
YVPE
D
RP
IV
V
T
G
A
V
Y
N
L
T
K
T
N
NL
M
A
DP
-
E
G
S
F
F
SVEG
GE
I
R
--------
AR
GVE
I
E
AK
---
A
AL
S
A
SVN
V
VG
SYTY
T
DAE
YT
--
TDTTY
K
G
-
N
TP
AQV
P
-----
KHMASLW
A
D
Y
T
F
F
DG
P
L
SG
-
LT
L
G
-----
T
G
G
R
Y
TG
--
S
S
Y
---
GD
P
A
N
-
S
F
K
V
--
GSY
T
V
VD
ALV
RY
D
LARVGMA
GS
N
VALH
VNNLFD
RE
Y
V
AS
CF
--
NT
YG
CF
W
GA
E
R
Q
V
VA
T
A
T
F
R
F
fig|340186.3.peg.669
Escherichia coli E110019 (16-747/747)
IAV
V
V
A
T
A
V
-----
-
SG
MS
---
-
-----
-
---
V
Y
A
Q
A
A
V
E
P
KE-
D
T
IT
VTA
-
A
P
---
AP
Q
E
SAW
G
-
-
P
A
A
T
IAARQSAT
GTK
TDT
P
IQ
KV
PQS
IS
VV
T
A
E
E
M
A
L
H
Q
PK
SV
K
E
A
L
S
Y
TPGV
---
S
V
G
T
R
GAS
N
T
Y
D
HLI
I
RGF
-
AAEGQ
SQ
N
NY
L
--
-
N
G
L
K
-
LQGNF
Y
N
--
DA
VI
D
P
-
YM
L
ER
A
E
I
M
RGP
V
S
V
L
YG
KS
S
PGG
LL
NMV
S
KR
P
T
TEP
LKEV
-----
Q
--
FK
A
------
G
T
D
SL
FQ
T
GF
D
F
S
DS
L
DD
DG
VYS
Y
R
LT
G
LA
R
S
A
N
A
Q
QKGSE
E
Q
R
YAIAPA
--
F
TW
RP
D
-
D
K
T
NF
T
F
LS
Y
-
FQN
E
------
P
E
T
G
YYGW
-
LP
KE
GT
V
-----
-E
P
L
--
PN
GK
--
RL
P
TDF
N
E
G
AK
N
NTYSRNEK
M
V
GY
S
F
D
H
E
F
N
DT
FTVR
Q
N
LR
F
A
E
N
K
--
-----
-
T
SQ
-------------------
NS
V
Y
G
Y
G
VC
S
D
PANAYSKQ
--------
CAALAPADKGH
Y
L
A
R
-
--
KY
------
VV
D
DE
K
L
QNF
S
V
D
TQ
L
QS
KF
AT
GDI
D
H
T
L
LT
G
V
----------
D
F
MR
MR
N
------------
D
I
NAW
F
G
YD
DS
V
P
LL
N
-
L
--
Y
N
P
-------------
VNTD
-
FD
FNAKDPANSGPYRI
L
N
KQ
K
Q
T
-
-
-
G
V
Y
VQ
D
QAQ
W
-
D
KVLVT
LG
G
R
-------
Y
DWAD
Q
-
ESLN
R
--------------
VAGTTD
-----
KR
DD
K
QF
----
T
W
RG
G
VNY
L
F
D
N
GVT
P
Y
F
SY
S
E
SF
E
P
---------
S
S
-
QV
G
KD
G
NI
-
F
A
P
S
K
G
KQ
YE
-------
V
G
V
K
YVPE
D
RP
IV
V
T
G
A
V
Y
N
L
T
K
T
N
NL
M
A
DP
-
E
G
S
F
F
SVEG
GE
I
R
--------
AR
GVE
I
E
AK
---
A
AL
S
A
SVN
V
VG
SYTY
T
DAE
YT
--
TDTTY
K
G
-
N
SP
AQV
P
-----
KHMASLW
A
G
Y
T
F
F
DG
P
L
SG
-
LT
L
G
-----
T
G
G
R
Y
TG
--
S
S
Y
---
GD
P
A
N
-
S
F
K
V
--
GSY
T
V
VD
ALV
RY
D
LARVGMA
GS
N
VALH
VNNLFD
RE
Y
V
AS
CF
--
NT
YG
CF
W
GA
E
R
Q
V
VA
T
A
T
F
R
F
fig|585397.7.peg.778
Escherichia coli ED1a (11-760/760)
QFHSLTF
FAG
L
C
I
G
I
T
P
V
A
-----
-
QA
LA
---
-
-----
-
---
A
E
G
Q
A
N
A
D
-
---
D
T
LV
V
E
AS
T
P
SLY
AP
Q
Q
SAD
P
-
-
-
-
--
------
--
-
-
K
FSR
P
VA
D
TT
RTM
TV
I
S
E
Q
V
I
K
D
Q
G
AT
N
L
T
D
A
L
K
N
V
PGV
GAF
F
A
G
E
N
G
N
S
T
T
G
D
AIY
M
RG
A
------
DT
S
N
S
I
-
Y
I
DGI
R
-
----D
IG
--
SV
SR
D
T
-
FN
T
E
Q
VEV
IK
GP
S
G
T
D
YG
RS
A
P
T
G
S
INM
I
S
K
Q
P
R
NDS
GIDASASIGSAW
F
R
R
------
G
T
-
--
--
-
-L
D
V
N
QV
I
GD
T
T
AVR
LN
VM
G
E-
K
T
H
D
A
G
RDKVK
N
E
R
Y
GV
AP
SVA
F
GL
GT
A
-
N
RL
YL
N
Y
L
HV
-
TQH
NTP
D
GGI
P
T
I
G
LP
G
YSA
P
SA
GT
A
---
AL
NH
S
G
KV
D
T
HN
FY
GT
D
SDY
D
D
S
IT
D
--------
T
A
TM
R
F
E
H
D
I
N
D
NA
T
I
R
N
T
TR
W
S
R
V
K
Q
D
-----
-
Y
LM
-------------------
TA
I
M
G
--
--
-
-
------------
GASNITQPTSDVNSW
T
W
S
R
T
A
N
TK
------
DV
S
NK
I
L
TN-
-
-
Q
TN
L
T
S
TF
Y
T
GAI
G
H
D
L
S
T
G
V
----------
E
FT
R
--
-
------------
E
T
QTN
YG
VN
PV
T
L
PA
VN
I
--
Y
H
P
DSSIHPGGLTRNG
ANAN
---
--------------
-
G
Q
T
D
T
F
-
-
-
A
I
YA
F
D
TLQ
I
T
R
DFELN
G
G
I
R
LDNYHTE
Y
DSAT
AC
GGSG
R
GAITCPAGVAKGSP
VTTVDT
-----
AK
SG
N
LV
----
N
W
KA
G
A
L
Y
H
L
T
E
N
G
N
V
Y
I
N
Y
A
V
S
Q
QP
PGGNNFALA
Q
S
G
SG
N
SA
N
RT
D
F
K
P
Q
K
A
N
TS
E
-------
I
G
T
K
WQVL
D
KR
L
L
L
T
A
A
L
F
R
T
D
I
E
N
EV
E
Q
---
N
D
D
G
T
YSQY
G
K
K
R
--------
V
E
G
Y
E
I
S
V
A
---
G
N
I
T
P
A
WQ
M
IG
G
YT
QQK
A
T
IK
NGK
D
VAQ
D
G
S
S
SL
P
YT
P
-----
E
H
AFT
LW
S
Q
Y
Q
A
T
D
D-
-
---
IS
V
G
-----
A
G
A
R
Y
IG
--
S
MH
KGS
DG
AV
G
TPAF
T
--
E
G
Y
W
VA
D
A
KLG
Y
R
V
N
R
----
NL
DF
Q
L
NV
Y
NLFD
TD
Y
V
AS
-I
NKSG
Y
R
YH
P
G
E
PR
T
F
LL
T
A
NMH
F
fig|585397.9.peg.778
Escherichia coli ED1a (11-760/760)
QFHSLTF
FAG
L
C
I
G
I
T
P
V
A
-----
-
QA
LA
---
-
-----
-
---
A
E
G
Q
A
N
A
D
-
---
D
T
LV
V
E
AS
T
P
SLY
AP
Q
Q
SAD
P
-
-
-
-
--
------
--
-
-
K
FSR
P
VA
D
TT
RTM
TV
I
S
E
Q
V
I
K
D
Q
G
AT
N
L
T
D
A
L
K
N
V
PGV
GAF
F
A
G
E
N
G
N
S
T
T
G
D
AIY
M
RG
A
------
DT
S
N
S
I
-
Y
I
DGI
R
-
----D
IG
--
SV
SR
D
T
-
FN
T
E
Q
VEV
IK
GP
S
G
T
D
YG
RS
A
P
T
G
S
INM
I
S
K
Q
P
R
NDS
GIDASASIGSAW
F
R
R
------
G
T
-
--
--
-
-L
D
V
N
QV
I
GD
T
T
AVR
LN
VM
G
E-
K
T
H
D
A
G
RDKVK
N
E
R
Y
GV
AP
SVA
F
GL
GT
A
-
N
RL
YL
N
Y
L
HV
-
TQH
NTP
D
GGI
P
T
I
G
LP
G
YSA
P
SA
GT
A
---
AL
NH
S
G
KV
D
T
HN
FY
GT
D
SDY
D
D
S
IT
D
--------
T
A
TM
R
F
E
H
D
I
N
D
NA
T
I
R
N
T
TR
W
S
R
V
K
Q
D
-----
-
Y
LM
-------------------
TA
I
M
G
--
--
-
-
------------
GASNITQPTSDVNSW
T
W
S
R
T
A
N
TK
------
DV
S
NK
I
L
TN-
-
-
Q
TN
L
T
S
TF
Y
T
GAI
G
H
D
L
S
T
G
V
----------
E
FT
R
--
-
------------
E
T
QTN
YG
VN
PV
T
L
PA
VN
I
--
Y
H
P
DSSIHPGGLTRNG
ANAN
---
--------------
-
G
Q
T
D
T
F
-
-
-
A
I
YA
F
D
TLQ
I
T
R
DFELN
G
G
I
R
LDNYHTE
Y
DSAT
AC
GGSG
R
GAITCPAGVAKGSP
VTTVDT
-----
AK
SG
N
LV
----
N
W
KA
G
A
L
Y
H
L
T
E
N
G
N
V
Y
I
N
Y
A
V
S
Q
QP
PGGNNFALA
Q
S
G
SG
N
SA
N
RT
D
F
K
P
Q
K
A
N
TS
E
-------
I
G
T
K
WQVL
D
KR
L
L
L
T
A
A
L
F
R
T
D
I
E
N
EV
E
Q
---
N
D
D
G
T
YSQY
G
K
K
R
--------
V
E
G
Y
E
I
S
V
A
---
G
N
I
T
P
A
WQ
M
IG
G
YT
QQK
A
T
IK
NGK
D
VAQ
D
G
S
S
SL
P
YT
P
-----
E
H
AFT
LW
S
Q
Y
Q
A
T
D
D-
-
---
IS
V
G
-----
A
G
A
R
Y
IG
--
S
MH
KGS
DG
AV
G
TPAF
T
--
E
G
Y
W
VA
D
A
KLG
Y
R
V
N
R
----
NL
DF
Q
L
NV
Y
NLFD
TD
Y
V
AS
-I
NKSG
Y
R
YH
P
G
E
PR
T
F
LL
T
A
NMH
F
fig|753642.3.peg.860
Escherichia coli NC101 (11-760/760)
QFHSLTF
FAG
L
C
I
G
I
T
P
V
A
-----
-
QA
LA
---
-
-----
-
---
A
E
G
Q
A
N
A
D
-
---
D
T
LV
V
E
AS
T
P
SLY
AP
Q
Q
SAD
P
-
-
-
-
--
------
--
-
-
K
FSR
P
VA
D
TT
RTM
TV
I
S
E
Q
V
I
K
D
Q
G
AT
N
L
T
D
A
L
K
N
V
PGV
GAF
F
A
G
E
N
G
N
S
T
T
G
D
AIY
M
RG
A
------
DT
S
N
S
I
-
Y
I
DGI
R
-
----D
IG
--
SV
SR
D
T
-
FN
T
E
Q
VEV
IK
GP
S
G
T
D
YG
RS
A
P
T
G
S
INM
I
S
K
Q
P
R
NDS
GIDASASIGSAW
F
R
R
------
G
T
-
--
--
-
-L
D
V
N
QV
I
GD
T
T
AVR
LN
VM
G
E-
K
T
H
D
A
G
RDKVK
N
E
R
Y
GV
AP
SVA
F
GL
GT
A
-
N
RL
YL
N
Y
L
HV
-
TQH
NTP
D
GGI
P
T
I
G
LP
G
YSA
P
SA
GT
A
---
AL
NH
S
G
KV
D
T
HN
FY
GT
D
SDY
D
D
S
IT
D
--------
T
A
TM
R
F
E
H
D
I
N
D
NA
T
I
R
N
T
TR
W
S
R
V
K
Q
D
-----
-
Y
LM
-------------------
TA
I
M
G
--
--
-
-
------------
GASNITQPTSDVNSW
T
W
S
R
T
A
N
TK
------
DV
S
NK
I
L
TN-
-
-
Q
TN
L
T
S
TF
Y
T
GAI
G
H
D
L
S
T
G
V
----------
E
FT
R
--
-
------------
E
T
QTN
YG
VN
PV
T
L
PA
VN
I
--
Y
H
P
DSSIHPGGLTRNG
ANAN
---
--------------
-
G
Q
T
D
T
F
-
-
-
A
I
YA
F
D
TLQ
I
T
R
DFELN
G
G
I
R
LDNYHTE
Y
DSAT
AC
GGSG
R
GAITCPAGVAKGSP
VTTVDT
-----
AK
SG
N
LV
----
N
W
KA
G
A
L
Y
H
L
T
E
N
G
N
V
Y
I
N
Y
A
V
S
Q
QP
PGGNNFALA
Q
S
G
SG
N
SA
N
RT
D
F
K
P
Q
K
A
N
TS
E
-------
I
G
T
K
WQVL
D
KR
L
L
L
T
A
A
L
F
R
T
D
I
E
N
EV
E
Q
---
N
D
D
G
T
YSQY
G
K
K
R
--------
V
E
G
Y
E
I
S
V
A
---
G
N
I
T
P
A
WQ
M
IG
G
YT
QQK
A
T
IK
NGK
D
VAQ
D
G
S
S
SL
P
YT
P
-----
E
H
AFT
LW
S
Q
Y
Q
A
T
D
D-
-
---
IS
V
G
-----
A
G
A
R
Y
IG
--
S
MH
KGS
DG
AV
G
TPAF
T
--
E
G
Y
W
VA
D
A
KLG
Y
R
V
N
R
----
NL
DF
Q
L
NV
Y
NLFD
TD
Y
V
AS
-I
NKSG
Y
R
YH
P
G
E
PR
T
F
LL
T
A
NMH
F
fig|685038.3.peg.731
Escherichia coli O83:H1 str. NRG 857C (11-760/760)
QFHSLTF
FAG
L
C
I
G
I
T
P
V
A
-----
-
QA
LA
---
-
-----
-
---
A
E
G
Q
A
N
A
D
-
---
D
T
LV
V
E
AS
T
P
SLY
AP
Q
Q
SAD
P
-
-
-
-
--
------
--
-
-
K
FSR
P
VA
D
TT
RTM
TV
I
S
E
Q
V
I
K
D
Q
G
AT
N
L
T
D
A
L
K
N
V
PGV
GAF
F
A
G
E
N
G
N
S
T
T
G
D
AIY
M
RG
A
------
DT
S
N
S
I
-
Y
I
DGI
R
-
----D
IG
--
SV
SR
D
T
-
FN
T
E
Q
VEV
IK
GP
S
G
T
D
YG
RS
A
P
T
G
S
INM
I
S
K
Q
P
R
NDS
GIDASASIGSAW
F
R
R
------
G
T
-
--
--
-
-L
D
V
N
QV
I
GD
T
T
AMR
LN
VM
G
E-
K
T
H
D
A
G
RDKVK
N
E
R
Y
GV
AP
SVA
F
GL
GT
A
-
N
RL
YL
N
Y
L
HV
-
TQH
NTP
D
GGI
P
T
I
G
LP
G
YSA
P
SA
GT
A
---
AL
NH
S
G
KV
D
T
HN
FY
GT
D
SDY
D
D
S
IT
D
--------
T
A
TM
R
F
E
H
D
I
N
D
NT
T
I
R
N
T
TR
W
S
R
V
K
Q
D
-----
-
Y
LM
-------------------
TA
I
M
G
--
--
-
-
------------
GASNITQPTSDVNSW
T
W
S
R
T
A
N
TK
------
DV
S
NK
I
L
TN-
-
-
Q
TN
L
T
S
TF
Y
T
GAI
G
H
D
L
S
T
G
V
----------
E
FT
R
--
-
------------
E
T
QTN
YG
VN
PV
T
L
PA
VN
I
--
Y
H
P
DSSIHPGGLTRNG
ANAN
---
--------------
-
G
Q
T
D
T
F
-
-
-
A
I
YA
F
D
TLQ
I
T
R
DFELN
G
G
I
R
LDNYHTE
Y
DSAT
AC
GGSG
R
GAITCPAGVAKGSP
VTTVDT
-----
AK
SG
N
LV
----
N
W
KA
G
A
L
Y
H
L
T
E
N
G
N
V
Y
I
N
Y
A
V
S
Q
QP
PGGNNFALA
Q
S
G
SG
N
SA
N
RT
D
F
K
P
Q
K
A
N
TS
E
-------
I
G
T
K
WQVL
D
KR
L
L
L
T
A
A
L
F
R
T
D
I
E
N
EV
E
Q
---
N
D
D
G
T
YSQY
G
K
K
R
--------
V
E
G
Y
E
I
S
V
A
---
G
N
I
T
P
A
WQ
M
IG
G
YT
QQK
A
T
IK
NGK
D
VAQ
D
G
S
S
SL
P
YT
P
-----
E
H
AFT
LW
S
Q
Y
Q
A
T
D
D-
-
---
IS
V
G
-----
A
G
A
R
Y
IG
--
S
MH
KGS
DG
AV
G
TPAF
T
--
E
G
Y
W
VA
D
A
KLG
Y
R
V
N
R
----
NL
DF
Q
L
NV
Y
NLFD
TD
Y
V
AS
-I
NKSG
Y
R
YH
P
G
E
PR
T
F
LL
T
A
NMH
F
fig|405955.9.peg.3742
Escherichia coli APEC O1 (14-629/629)
F
T
M
IKK
AS
LL
T
A
C
S
V
-----
-
T
A
FS
---
-
-----
-
---
-
-
-
-
A
W
A
Q
D
TSP
D
T
LV
VTA
-
-
-
---
-
-
-
-
---
-
-
-
-
-
--
------
--
-
N
R
F
E
Q
P
RS
T
V
LA
P
T
TVV
T
R
Q
D
I
D
R
W
Q
ST
SV
N
D
VL
R
R
L
PGV
---
D
I
T
Q
N
G
G
S
G
Q
L
S
SIF
I
RG
T
------
NA
S
H
V
L
V
L
I
DG
V
R
L
NLAGV
SGSA
D
L
SQ
FP
I
AL
V
Q
RVE
Y
I
RGP
R
S
A
V
YG
SD
AI
GG
V
V
N
I
I
T
T
R
D
H
---
------------
P
G
T
EI
SA
G
W
GS
N
S
Y
QN
Y
DV
S
T
Q
QQ
L
G-
-
-
---
-----
--
--
-
-
-
-
-----
--
-
--
------
-
--
--
-
-
D
K
T
RV
T
L
L
G
DY
AHT
H
------
-
-
-
G
Y
DVVA
YG
NT
GT
Q
-----
AQ
P
D
--
--
--
--
--
-
---
NDG
FL
S
-------
K
T
L
YG
A
L
E
H
N
F
T
D
V
W
S--
-
-
--
---
-
-
--
-----
-
-
--
-------------------
GF
V
R
G
Y
G
YD
N
-
---------------------------
-
-
R
T
N
Y
DA
Y
YSPGLP
LV
D
TR
K
L
YSQ
S
W
D
AG
L
RY
NG
EL
--I
K
S
Q
L
I
T
SY
----------
S
H
SK
DY
N
------------
-
Y
DPH
YG
RY
DS
S
A
TL
D
E
M
KQ
Y
T
V
-------------
QWAN
NII
IGHGNIGAGVDW--
-
-
Q
KQ
S
T
APG
T
A
Y
V
E
D
GYD
Q
R
N
TGIYL
T
G
L
Q
-------
Q
VGDF
T
F
EGAG
R
--------------
------
-----
SD
D
N
S
QF
GRHG
T
W
QT
SAG
W
E
F
I
E
G
Y
R
F
I
ASY
G
T
S
YK
APN
-------
L
G
Q
LY
G
TY
G
NP
N
L
N
P
E
KSKQ
W
E
GAFEGLTA
G
V
N
WR--
-
--
--
-
-
I
S
G
Y
R
N
D
V
S
DL
I
D
Y
D
--
D
H
T
L
K
YYNE
G
K
A
R
--------
I
KGVE
A
TA
N
FDT
G
P
LT
H
T
V
--
--
SY
D
Y
V
DA
R
--
-------
-
-
-
N
AI
T
D
T
P
LLRRA
K
QQ
VK
YQ
L
D
W
Q
L
Y
D
--
-
---
FD
W
G
ITYQYL
G
T
R
Y
DK
DY
S
S
Y
---
--
PY
Q
-
T
VK
M
--
G
G
V
S
L
W
DL
A
VA
Y
P
VT
S
----
HL
T
V
R
G
K
I
A
NLFDK
D
Y
E
T
-
--
--
-
VYG
YQ
-
T
A
G
R
E
Y
TL
S
G
S
Y
T
F
fig|562.376.peg.1310
Escherichia coli WV_060327 (2-614/614)
IKK
AS
LL
T
A
C
S
V
-----
-
T
A
FS
---
-
-----
-
---
-
-
-
-
A
W
A
Q
D
TSP
D
T
LV
VTA
-
-
-
---
-
-
-
-
---
-
-
-
-
-
--
------
--
-
N
R
F
E
Q
P
RS
T
V
LA
P
T
TVV
T
R
Q
D
I
D
R
W
Q
ST
SV
N
D
VL
R
R
L
PGV
---
D
I
T
Q
N
G
G
S
G
Q
L
S
SIF
I
RG
T
------
NA
S
H
V
L
V
L
I
DG
V
R
L
NLAGV
SGSA
D
L
SQ
FP
I
AL
V
Q
RVE
Y
I
RGP
R
S
A
V
YG
SD
AI
GG
V
V
N
I
I
T
T
R
D
H
---
------------
P
G
T
EI
SA
G
W
GS
N
S
Y
QN
Y
DV
S
T
Q
QQ
L
G-
-
-
---
-----
--
--
-
-
-
-
-----
--
-
--
------
-
--
--
-
-
D
K
T
RV
T
L
L
G
DY
AHT
H
------
-
-
-
G
Y
DVVA
YG
NT
GT
Q
-----
AQ
P
D
--
--
--
--
--
-
---
NDG
FL
S
-------
K
T
L
YG
A
L
E
H
N
F
T
D
V
W
S--
-
-
--
---
-
-
--
-----
-
-
--
-------------------
GF
V
R
G
Y
G
YD
N
-
---------------------------
-
-
R
T
N
Y
DA
Y
YSPGLP
LV
D
TR
K
L
YSQ
S
W
D
AG
L
RY
NG
K
L
--I
K
S
Q
L
I
SSY
----------
S
H
SK
DY
N
------------
-
Y
DPH
YG
RY
DS
S
A
TL
D
E
M
KQ
Y
T
V
-------------
QWAN
NII
IGHGNIGAGVDW--
-
-
Q
KQ
S
T
APG
T
A
Y
V
E
D
GYD
Q
R
N
TGIYL
T
G
L
Q
-------
Q
VGDF
T
F
EGAG
R
--------------
------
-----
SD
D
N
S
QF
GRHG
T
W
QT
SAG
W
E
F
I
E
G
Y
R
F
I
ASY
G
T
S
YK
APN
-------
L
G
Q
LY
G
TY
G
NP
N
L
N
P
E
KSKQ
W
E
GAFEGLTA
G
V
N
WR--
-
--
--
-
-
I
S
G
Y
R
N
D
V
S
DL
I
D
Y
D
--
D
H
T
L
K
YYNE
G
K
A
R
--------
I
KGVE
A
TA
N
FDT
G
P
LT
H
T
V
--
--
SY
D
Y
V
DA
R
--
-------
-
-
-
N
AI
T
D
T
P
LLRRA
K
QQ
VK
YQ
L
D
W
Q
L
Y
D
--
-
---
FD
W
G
ITYQYL
G
T
R
Y
DK
DY
S
S
Y
---
--
PY
Q
-
T
VK
M
--
G
G
V
S
L
W
DL
A
VA
Y
P
VT
S
----
HL
T
V
R
G
K
I
A
NLFDK
D
Y
E
T
-
--
--
-
VYG
YQ
-
T
A
G
R
E
Y
TL
S
G
S
Y
T
F
fig|362663.8.peg.4217
Escherichia coli 536 (2-614/614)
IKK
AS
LL
T
A
C
S
V
-----
-
T
A
FS
---
-
-----
-
---
-
-
-
-
A
W
A
Q
D
TSP
D
T
LV
VTA
-
-
-
---
-
-
-
-
---
-
-
-
-
-
--
------
--
-
N
R
F
E
Q
P
RS
T
V
LA
P
T
TVV
T
R
Q
D
I
D
R
W
Q
ST
SV
N
D
VL
R
R
L
PGV
---
D
I
T
Q
N
G
G
S
G
Q
L
S
SIF
I
RG
T
------
NA
S
H
V
L
V
L
I
DG
V
R
L
NLAGV
SGSA
D
L
SQ
FP
I
AL
V
Q
RVE
Y
I
RGP
R
S
A
V
YG
SD
AI
GG
V
V
N
I
I
T
T
R
D
H
---
------------
P
G
T
EI
SA
G
W
GS
N
S
Y
QN
Y
DV
S
T
Q
QQ
L
G-
-
-
---
-----
--
--
-
-
-
-
-----
--
-
--
------
-
--
--
-
-
D
K
T
RV
T
L
L
G
DY
AHT
H
------
-
-
-
G
Y
DVVA
YG
NT
GT
Q
-----
AQ
P
D
--
--
--
--
--
-
---
NDG
FL
S
-------
K
T
L
YG
A
L
E
H
N
F
T
D
V
W
S--
-
-
--
---
-
-
--
-----
-
-
--
-------------------
GF
V
R
G
Y
G
YD
N
-
---------------------------
-
-
R
T
N
Y
DA
Y
YSPGLP
LV
D
TR
K
L
YSQ
S
W
D
AG
L
RY
NG
EL
--I
K
S
Q
L
I
T
SY
----------
S
H
SK
DY
N
------------
-
Y
DPH
YG
RY
DS
S
A
TL
D
E
M
KQ
Y
T
V
-------------
QWAN
NII
IGHGNIGAGVDW--
-
-
Q
KQ
S
T
APG
T
A
Y
V
E
D
GYD
Q
R
N
TGIYL
T
G
L
Q
-------
Q
VGDF
T
F
EGAG
R
--------------
------
-----
SD
D
N
S
QF
GRHG
T
W
QT
SAG
W
E
F
I
E
G
Y
R
F
I
ASY
G
T
S
YK
APN
-------
L
G
Q
LY
G
SY
G
NP
N
L
N
P
E
KSKQ
W
E
GAFEGLTA
G
V
N
WR--
-
--
--
-
-
I
S
G
Y
R
N
D
V
S
DL
I
D
Y
D
--
D
H
T
L
K
YYNE
G
K
A
R
--------
I
KGVE
A
TA
N
FDT
G
P
LT
H
T
V
--
--
SY
D
Y
V
DA
R
--
-------
-
-
-
N
AI
T
D
T
P
LLRRA
K
QQ
VK
YQ
L
D
W
Q
L
Y
D
--
-
---
FD
W
G
ITYQYL
G
T
R
Y
DK
DY
S
S
Y
---
--
PY
Q
-
T
VK
M
--
G
G
V
S
L
W
DL
A
VA
Y
P
VT
S
----
HL
T
V
R
G
K
I
A
NLFDK
D
Y
E
T
-
--
--
-
VYG
YQ
-
T
A
G
R
E
Y
TL
S
G
S
Y
T
F
fig|362663.9.peg.4233
Escherichia coli 536 (2-614/614)
IKK
AS
LL
T
A
C
S
V
-----
-
T
A
FS
---
-
-----
-
---
-
-
-
-
A
W
A
Q
D
TSP
D
T
LV
VTA
-
-
-
---
-
-
-
-
---
-
-
-
-
-
--
------
--
-
N
R
F
E
Q
P
RS
T
V
LA
P
T
TVV
T
R
Q
D
I
D
R
W
Q
ST
SV
N
D
VL
R
R
L
PGV
---
D
I
T
Q
N
G
G
S
G
Q
L
S
SIF
I
RG
T
------
NA
S
H
V
L
V
L
I
DG
V
R
L
NLAGV
SGSA
D
L
SQ
FP
I
AL
V
Q
RVE
Y
I
RGP
R
S
A
V
YG
SD
AI
GG
V
V
N
I
I
T
T
R
D
H
---
------------
P
G
T
EI
SA
G
W
GS
N
S
Y
QN
Y
DV
S
T
Q
QQ
L
G-
-
-
---
-----
--
--
-
-
-
-
-----
--
-
--
------
-
--
--
-
-
D
K
T
RV
T
L
L
G
DY
AHT
H
------
-
-
-
G
Y
DVVA
YG
NT
GT
Q
-----
AQ
P
D
--
--
--
--
--
-
---
NDG
FL
S
-------
K
T
L
YG
A
L
E
H
N
F
T
D
V
W
S--
-
-
--
---
-
-
--
-----
-
-
--
-------------------
GF
V
R
G
Y
G
YD
N
-
---------------------------
-
-
R
T
N
Y
DA
Y
YSPGLP
LV
D
TR
K
L
YSQ
S
W
D
AG
L
RY
NG
EL
--I
K
S
Q
L
I
T
SY
----------
S
H
SK
DY
N
------------
-
Y
DPH
YG
RY
DS
S
A
TL
D
E
M
KQ
Y
T
V
-------------
QWAN
NII
IGHGNIGAGVDW--
-
-
Q
KQ
S
T
APG
T
A
Y
V
E
D
GYD
Q
R
N
TGIYL
T
G
L
Q
-------
Q
VGDF
T
F
EGAG
R
--------------
------
-----
SD
D
N
S
QF
GRHG
T
W
QT
SAG
W
E
F
I
E
G
Y
R
F
I
ASY
G
T
S
YK
APN
-------
L
G
Q
LY
G
SY
G
NP
N
L
N
P
E
KSKQ
W
E
GAFEGLTA
G
V
N
WR--
-
--
--
-
-
I
S
G
Y
R
N
D
V
S
DL
I
D
Y
D
--
D
H
T
L
K
YYNE
G
K
A
R
--------
I
KGVE
A
TA
N
FDT
G
P
LT
H
T
V
--
--
SY
D
Y
V
DA
R
--
-------
-
-
-
N
AI
T
D
T
P
LLRRA
K
QQ
VK
YQ
L
D
W
Q
L
Y
D
--
-
---
FD
W
G
ITYQYL
G
T
R
Y
DK
DY
S
S
Y
---
--
PY
Q
-
T
VK
M
--
G
G
V
S
L
W
DL
A
VA
Y
P
VT
S
----
HL
T
V
R
G
K
I
A
NLFDK
D
Y
E
T
-
--
--
-
VYG
YQ
-
T
A
G
R
E
Y
TL
S
G
S
Y
T
F
fig|749550.3.peg.2734
Escherichia coli MS 200-1 (2-614/614)
IKK
AS
LL
T
A
C
S
V
-----
-
T
A
FS
---
-
-----
-
---
-
-
-
-
A
W
A
Q
D
TSP
D
T
LV
VTA
-
-
-
---
-
-
-
-
---
-
-
-
-
-
--
------
--
-
N
R
F
E
Q
P
RS
T
V
LA
P
T
TVV
T
R
Q
D
I
D
R
W
Q
ST
SV
N
D
VL
R
R
L
PGV
---
D
I
T
Q
N
G
G
S
G
Q
L
S
SIF
I
RG
T
------
NA
S
H
V
L
V
L
I
DG
V
R
L
NLAGV
SGSA
D
L
SQ
FP
I
AL
V
Q
RVE
Y
I
RGP
R
S
A
V
YG
SD
AI
GG
V
V
N
I
I
T
T
R
D
H
---
------------
P
G
T
EI
SA
G
W
GS
N
S
Y
QN
Y
DV
S
T
Q
QQ
L
G-
-
-
---
-----
--
--
-
-
-
-
-----
--
-
--
------
-
--
--
-
-
D
K
T
RV
T
L
L
G
DY
AHT
H
------
-
-
-
G
Y
DVVA
YG
NT
GT
Q
-----
AQ
P
D
--
--
--
--
--
-
---
NDG
FL
S
-------
K
T
L
YG
A
L
E
H
N
F
T
D
V
W
S--
-
-
--
---
-
-
--
-----
-
-
--
-------------------
GF
V
R
G
Y
G
YD
N
-
---------------------------
-
-
R
T
N
Y
DA
Y
YSPGLP
LV
D
TR
K
L
YSQ
S
W
D
AG
L
RY
NG
EL
--I
K
S
Q
L
I
T
SY
----------
S
H
SK
DY
N
------------
-
Y
DPH
YG
RY
DS
S
A
TL
D
E
M
KQ
Y
T
V
-------------
QWAN
NII
IGHGNIGAGVDW--
-
-
Q
KQ
S
T
APG
T
A
Y
V
E
D
GYD
Q
R
N
TGIYL
T
G
L
Q
-------
Q
VGDF
T
F
EGAG
R
--------------
------
-----
SD
D
N
S
QF
GRHG
T
W
QT
SAG
W
E
F
I
E
G
Y
R
F
I
ASY
G
T
S
YK
APN
-------
L
G
Q
LY
G
SY
G
NP
N
L
N
P
E
KSKQ
W
E
GAFEGLTA
G
V
N
WR--
-
--
--
-
-
I
S
G
Y
R
N
D
V
S
DL
I
D
Y
D
--
D
H
T
L
K
YYNE
G
K
A
R
--------
I
KGVE
A
TA
N
FDT
G
P
LT
H
T
V
--
--
SY
D
Y
V
DA
R
--
-------
-
-
-
N
AI
T
D
T
P
LLRRA
K
QQ
VK
YQ
L
D
W
Q
L
Y
D
--
-
---
FD
W
G
ITYQYL
G
T
R
Y
DK
DY
S
S
Y
---
--
PY
Q
-
T
VK
M
--
G
G
V
S
L
W
DL
A
VA
Y
P
VT
S
----
HL
T
V
R
G
K
I
A
NLFDK
D
Y
E
T
-
--
--
-
VYG
YQ
-
T
A
G
R
E
Y
TL
S
G
S
Y
T
F
fig|405955.13.peg.4443
Escherichia coli APEC O1 (2-614/614)
IKK
AS
LL
T
A
C
S
V
-----
-
T
A
FS
---
-
-----
-
---
-
-
-
-
A
W
A
Q
D
TSP
D
T
LV
VTA
-
-
-
---
-
-
-
-
---
-
-
-
-
-
--
------
--
-
N
R
F
E
Q
P
RS
T
V
LA
P
T
TVV
T
R
Q
D
I
D
R
W
Q
ST
SV
N
D
VL
R
R
L
PGV
---
D
I
T
Q
N
G
G
S
G
Q
L
S
SIF
I
RG
T
------
NA
S
H
V
L
V
L
I
DG
V
R
L
NLAGV
SGSA
D
L
SQ
FP
I
AL
V
Q
RVE
Y
I
RGP
R
S
A
V
YG
SD
AI
GG
V
V
N
I
I
T
T
R
D
H
---
------------
P
G
T
EI
SA
G
W
GS
N
S
Y
QN
Y
DV
S
T
Q
QQ
L
G-
-
-
---
-----
--
--
-
-
-
-
-----
--
-
--
------
-
--
--
-
-
D
K
T
RV
T
L
L
G
DY
AHT
H
------
-
-
-
G
Y
DVVA
YG
NT
GT
Q
-----
AQ
P
D
--
--
--
--
--
-
---
NDG
FL
S
-------
K
T
L
YG
A
L
E
H
N
F
T
D
V
W
S--
-
-
--
---
-
-
--
-----
-
-
--
-------------------
GF
V
R
G
Y
G
YD
N
-
---------------------------
-
-
R
T
N
Y
DA
Y
YSPGLP
LV
D
TR
K
L
YSQ
S
W
D
AG
L
RY
NG
EL
--I
K
S
Q
L
I
T
SY
----------
S
H
SK
DY
N
------------
-
Y
DPH
YG
RY
DS
S
A
TL
D
E
M
KQ
Y
T
V
-------------
QWAN
NII
IGHGNIGAGVDW--
-
-
Q
KQ
S
T
APG
T
A
Y
V
E
D
GYD
Q
R
N
TGIYL
T
G
L
Q
-------
Q
VGDF
T
F
EGAG
R
--------------
------
-----
SD
D
N
S
QF
GRHG
T
W
QT
SAG
W
E
F
I
E
G
Y
R
F
I
ASY
G
T
S
YK
APN
-------
L
G
Q
LY
G
TY
G
NP
N
L
N
P
E
KSKQ
W
E
GAFEGLTA
G
V
N
WR--
-
--
--
-
-
I
S
G
Y
R
N
D
V
S
DL
I
D
Y
D
--
D
H
T
L
K
YYNE
G
K
A
R
--------
I
KGVE
A
TA
N
FDT
G
P
LT
H
T
V
--
--
SY
D
Y
V
DA
R
--
-------
-
-
-
N
AI
T
D
T
P
LLRRA
K
QQ
VK
YQ
L
D
W
Q
L
Y
D
--
-
---
FD
W
G
ITYQYL
G
T
R
Y
DK
DY
S
S
Y
---
--
PY
Q
-
T
VK
M
--
G
G
V
S
L
W
DL
A
VA
Y
P
VT
S
----
HL
T
V
R
G
K
I
A
NLFDK
D
Y
E
T
-
--
--
-
VYG
YQ
-
T
A
G
R
E
Y
TL
S
G
S
Y
T
F
fig|585035.6.peg.4342
Escherichia coli S88 (2-614/614)
IKK
AS
LL
T
A
C
S
V
-----
-
T
A
FS
---
-
-----
-
---
-
-
-
-
A
W
A
Q
D
TSP
D
T
LV
VTA
-
-
-
---
-
-
-
-
---
-
-
-
-
-
--
------
--
-
N
R
F
E
Q
P
RS
T
V
LA
P
T
TVV
T
R
Q
D
I
D
R
W
Q
ST
SV
N
D
VL
R
R
L
PGV
---
D
I
T
Q
N
G
G
S
G
Q
L
S
SIF
I
RG
T
------
NA
S
H
V
L
V
L
I
DG
V
R
L
NLAGV
SGSA
D
L
SQ
FP
I
AL
V
Q
RVE
Y
I
RGP
R
S
A
V
YG
SD
AI
GG
V
V
N
I
I
T
T
R
D
H
---
------------
P
G
T
EI
SA
G
W
GS
N
S
Y
QN
Y
DV
S
T
Q
QQ
L
G-
-
-
---
-----
--
--
-
-
-
-
-----
--
-
--
------
-
--
--
-
-
D
K
T
RV
T
L
L
G
DY
AHT
H
------
-
-
-
G
Y
DVVA
YG
NT
GT
Q
-----
AQ
P
D
--
--
--
--
--
-
---
NDG
FL
S
-------
K
T
L
YG
A
L
E
H
N
F
T
D
V
W
S--
-
-
--
---
-
-
--
-----
-
-
--
-------------------
GF
V
R
G
Y
G
YD
N
-
---------------------------
-
-
R
T
N
Y
DA
Y
YSPGLP
LV
D
TR
K
L
YSQ
S
W
D
AG
L
RY
NG
EL
--I
K
S
Q
L
I
T
SY
----------
S
H
SK
DY
N
------------
-
Y
DPH
YG
RY
DS
S
A
TL
D
E
M
KQ
Y
T
V
-------------
QWAN
NII
IGHGNIGAGVDW--
-
-
Q
KQ
S
T
APG
T
A
Y
V
E
D
GYD
Q
R
N
TGIYL
T
G
L
Q
-------
Q
VGDF
T
F
EGAG
R
--------------
------
-----
SD
D
N
S
QF
GRHG
T
W
QT
SAG
W
E
F
I
E
G
Y
R
F
I
ASY
G
T
S
YK
APN
-------
L
G
Q
LY
G
TY
G
NP
N
L
N
P
E
KSKQ
W
E
GAFEGLTA
G
V
N
WR--
-
--
--
-
-
I
S
G
Y
R
N
D
V
S
DL
I
D
Y
D
--
D
H
T
L
K
YYNE
G
K
A
R
--------
I
KGVE
A
TA
N
FDT
G
P
LT
H
T
V
--
--
SY
D
Y
V
DA
R
--
-------
-
-
-
N
AI
T
D
T
P
LLRRA
K
QQ
VK
YQ
L
D
W
Q
L
Y
D
--
-
---
FD
W
G
ITYQYL
G
T
R
Y
DK
DY
S
S
Y
---
--
PY
Q
-
T
VK
M
--
G
G
V
S
L
W
DL
A
VA
Y
P
VT
S
----
HL
T
V
R
G
K
I
A
NLFDK
D
Y
E
T
-
--
--
-
VYG
YQ
-
T
A
G
R
E
Y
TL
S
G
S
Y
T
F
fig|869729.3.peg.4320
Escherichia coli UM146 (2-614/614)
IKK
AS
LL
T
A
C
S
V
-----
-
T
A
FS
---
-
-----
-
---
-
-
-
-
A
W
A
Q
D
TSP
D
T
LV
VTA
-
-
-
---
-
-
-
-
---
-
-
-
-
-
--
------
--
-
N
R
F
E
Q
P
RS
T
V
LA
P
T
TVV
T
R
Q
D
I
D
R
W
Q
ST
SV
N
D
VL
R
R
L
PGV
---
D
I
T
Q
N
G
G
S
G
Q
L
S
SIF
I
RG
T
------
NA
S
H
V
L
V
L
I
DG
V
R
L
NLAGV
SGSA
D
L
SQ
FP
I
AL
V
Q
RVE
Y
I
RGP
R
S
A
V
YG
SD
AI
GG
V
V
N
I
I
T
T
R
D
H
---
------------
P
G
T
EI
SA
G
W
GS
N
S
Y
QN
Y
DV
S
T
Q
QQ
L
G-
-
-
---
-----
--
--
-
-
-
-
-----
--
-
--
------
-
--
--
-
-
D
K
T
RV
T
L
L
G
DY
AHT
H
------
-
-
-
G
Y
DVVA
YG
NT
GT
Q
-----
AQ
P
D
--
--
--
--
--
-
---
NDG
FL
S
-------
K
T
L
YG
A
L
E
H
N
F
T
D
V
W
S--
-
-
--
---
-
-
--
-----
-
-
--
-------------------
GF
V
R
G
Y
G
YD
N
-
---------------------------
-
-
R
T
N
Y
DA
Y
YSPGLP
LV
D
TR
K
L
YSQ
S
W
D
AG
L
RY
NG
EL
--I
K
S
Q
L
I
T
SY
----------
S
H
SK
DY
N
------------
-
Y
DPH
YG
RY
DS
S
A
TL
D
E
M
KQ
Y
T
V
-------------
QWAN
NII
IGHGNIGAGVDW--
-
-
Q
KQ
S
T
APG
T
A
Y
V
E
D
GYD
Q
R
N
TGIYL
T
G
L
Q
-------
Q
VGDF
T
F
EGAG
R
--------------
------
-----
SD
D
N
S
QF
GRHG
T
W
QT
SAG
W
E
F
I
E
G
Y
R
F
I
ASY
G
T
S
YK
APN
-------
L
G
Q
LY
G
TY
G
NP
N
L
N
P
E
KSKQ
W
E
GAFEGLTA
G
V
N
WR--
-
--
--
-
-
I
S
G
Y
R
N
D
V
S
DL
I
D
Y
D
--
D
H
T
L
K
YYNE
G
K
A
R
--------
I
KGVE
A
TA
N
FDT
G
P
LT
H
T
V
--
--
SY
D
Y
V
DA
R
--
-------
-
-
-
N
AI
T
D
T
P
LLRRA
K
QQ
VK
YQ
L
D
W
Q
L
Y
D
--
-
---
FD
W
G
ITYQYL
G
T
R
Y
DK
DY
S
S
Y
---
--
PY
Q
-
T
VK
M
--
G
G
V
S
L
W
DL
A
VA
Y
P
VT
S
----
HL
T
V
R
G
K
I
A
NLFDK
D
Y
E
T
-
--
--
-
VYG
YQ
-
T
A
G
R
E
Y
TL
S
G
S
Y
T
F
fig|364106.7.peg.4448
Escherichia coli UTI89 (2-614/614)
IKK
AS
LL
T
A
C
S
V
-----
-
T
A
FS
---
-
-----
-
---
-
-
-
-
A
W
A
Q
D
TSP
D
T
LV
VTA
-
-
-
---
-
-
-
-
---
-
-
-
-
-
--
------
--
-
N
R
F
E
Q
P
RS
T
V
LA
P
T
TVV
T
R
Q
D
I
D
R
W
Q
ST
SV
N
D
VL
R
R
L
PGV
---
D
I
T
Q
N
G
G
S
G
Q
L
S
SIF
I
RG
T
------
NA
S
H
V
L
V
L
I
DG
V
R
L
NLAGV
SGSA
D
L
SQ
FP
I
AL
V
Q
RVE
Y
I
RGP
R
S
A
V
YG
SD
AI
GG
V
V
N
I
I
T
T
R
D
H
---
------------
P
G
T
EI
SA
G
W
GS
N
S
Y
QN
Y
DV
S
T
Q
QQ
L
G-
-
-
---
-----
--
--
-
-
-
-
-----
--
-
--
------
-
--
--
-
-
D
K
T
RV
T
L
L
G
DY
AHT
H
------
-
-
-
G
Y
DVVA
YG
NT
GT
Q
-----
AQ
P
D
--
--
--
--
--
-
---
NDG
FL
S
-------
K
T
L
YG
A
L
E
H
N
F
T
D
V
W
S--
-
-
--
---
-
-
--
-----
-
-
--
-------------------
GF
V
R
G
Y
G
YD
N
-
---------------------------
-
-
R
T
N
Y
DA
Y
YSPGLP
LV
D
TR
K
L
YSQ
S
W
D
AG
L
RY
NG
EL
--I
K
S
Q
L
I
T
SY
----------
S
H
SK
DY
N
------------
-
Y
DPH
YG
RY
DS
S
A
TL
D
E
M
KQ
Y
T
V
-------------
QWAN
NII
IGHGNIGAGVDW--
-
-
Q
KQ
S
T
APG
T
A
Y
V
E
D
GYD
Q
R
N
TGIYL
T
G
L
Q
-------
Q
VGDF
T
F
EGAG
R
--------------
------
-----
SD
D
N
S
QF
GRHG
T
W
QT
SAG
W
E
F
I
E
G
Y
R
F
I
ASY
G
T
S
YK
APN
-------
L
G
Q
LY
G
TY
G
NP
N
L
N
P
E
KSKQ
W
E
GAFEGLTA
G
V
N
WR--
-
--
--
-
-
I
S
G
Y
R
N
D
V
S
DL
I
D
Y
D
--
D
H
T
L
K
YYNE
G
K
A
R
--------
I
KGVE
A
TA
N
FDT
G
P
LT
H
T
V
--
--
SY
D
Y
V
DA
R
--
-------
-
-
-
N
AI
T
D
T
P
LLRRA
K
QQ
VK
YQ
L
D
W
Q
L
Y
D
--
-
---
FD
W
G
ITYQYL
G
T
R
Y
DK
DY
S
S
Y
---
--
PY
Q
-
T
VK
M
--
G
G
V
S
L
W
DL
A
VA
Y
P
VT
S
----
HL
T
V
R
G
K
I
A
NLFDK
D
Y
E
T
-
--
--
-
VYG
YQ
-
T
A
G
R
E
Y
TL
S
G
S
Y
T
F
fig|364106.8.peg.4449
Escherichia coli UTI89 (2-614/614)
IKK
AS
LL
T
A
C
S
V
-----
-
T
A
FS
---
-
-----
-
---
-
-
-
-
A
W
A
Q
D
TSP
D
T
LV
VTA
-
-
-
---
-
-
-
-
---
-
-
-
-
-
--
------
--
-
N
R
F
E
Q
P
RS
T
V
LA
P
T
TVV
T
R
Q
D
I
D
R
W
Q
ST
SV
N
D
VL
R
R
L
PGV
---
D
I
T
Q
N
G
G
S
G
Q
L
S
SIF
I
RG
T
------
NA
S
H
V
L
V
L
I
DG
V
R
L
NLAGV
SGSA
D
L
SQ
FP
I
AL
V
Q
RVE
Y
I
RGP
R
S
A
V
YG
SD
AI
GG
V
V
N
I
I
T
T
R
D
H
---
------------
P
G
T
EI
SA
G
W
GS
N
S
Y
QN
Y
DV
S
T
Q
QQ
L
G-
-
-
---
-----
--
--
-
-
-
-
-----
--
-
--
------
-
--
--
-
-
D
K
T
RV
T
L
L
G
DY
AHT
H
------
-
-
-
G
Y
DVVA
YG
NT
GT
Q
-----
AQ
P
D
--
--
--
--
--
-
---
NDG
FL
S
-------
K
T
L
YG
A
L
E
H
N
F
T
D
V
W
S--
-
-
--
---
-
-
--
-----
-
-
--
-------------------
GF
V
R
G
Y
G
YD
N
-
---------------------------
-
-
R
T
N
Y
DA
Y
YSPGLP
LV
D
TR
K
L
YSQ
S
W
D
AG
L
RY
NG
EL
--I
K
S
Q
L
I
T
SY
----------
S
H
SK
DY
N
------------
-
Y
DPH
YG
RY
DS
S
A
TL
D
E
M
KQ
Y
T
V
-------------
QWAN
NII
IGHGNIGAGVDW--
-
-
Q
KQ
S
T
APG
T
A
Y
V
E
D
GYD
Q
R
N
TGIYL
T
G
L
Q
-------
Q
VGDF
T
F
EGAG
R
--------------
------
-----
SD
D
N
S
QF
GRHG
T
W
QT
SAG
W
E
F
I
E
G
Y
R
F
I
ASY
G
T
S
YK
APN
-------
L
G
Q
LY
G
TY
G
NP
N
L
N
P
E
KSKQ
W
E
GAFEGLTA
G
V
N
WR--
-
--
--
-
-
I
S
G
Y
R
N
D
V
S
DL
I
D
Y
D
--
D
H
T
L
K
YYNE
G
K
A
R
--------
I
KGVE
A
TA
N
FDT
G
P
LT
H
T
V
--
--
SY
D
Y
V
DA
R
--
-------
-
-
-
N
AI
T
D
T
P
LLRRA
K
QQ
VK
YQ
L
D
W
Q
L
Y
D
--
-
---
FD
W
G
ITYQYL
G
T
R
Y
DK
DY
S
S
Y
---
--
PY
Q
-
T
VK
M
--
G
G
V
S
L
W
DL
A
VA
Y
P
VT
S
----
HL
T
V
R
G
K
I
A
NLFDK
D
Y
E
T
-
--
--
-
VYG
YQ
-
T
A
G
R
E
Y
TL
S
G
S
Y
T
F
fig|199310.1.peg.4826
Escherichia coli CFT073 (14-629/629)
F
T
M
IKK
AS
LL
T
A
C
S
V
-----
-
T
A
FS
---
-
-----
-
---
-
-
-
-
A
W
A
Q
D
TSP
D
T
LV
VTA
-
-
-
---
-
-
-
-
---
-
-
-
-
-
--
------
--
-
N
R
F
E
Q
P
RS
T
V
LA
P
T
TVV
T
R
Q
D
I
D
R
W
Q
ST
SV
N
D
VL
R
R
L
PGV
---
D
I
T
Q
N
G
G
S
G
Q
L
S
SIF
I
RG
T
------
NA
S
H
V
L
V
L
I
DG
V
R
L
NLAGV
SGSA
D
L
SQ
FP
I
AL
V
Q
RVE
Y
I
RGP
R
S
A
V
YG
SD
AI
GG
V
V
N
I
I
T
T
R
D
H
---
------------
P
G
T
EI
SA
G
W
GS
N
S
Y
QN
Y
DV
S
T
Q
QQ
L
G-
-
-
---
-----
--
--
-
-
-
-
-----
--
-
--
------
-
--
--
-
-
D
K
T
RV
T
L
L
G
DY
AHT
H
------
-
-
-
G
Y
DVVA
YG
NT
GT
Q
-----
AQ
P
D
--
--
--
--
--
-
---
NDG
FL
S
-------
K
T
L
YG
A
L
E
H
N
F
T
D
A
W
S--
-
-
--
---
-
-
--
-----
-
-
--
-------------------
GF
V
R
G
Y
G
YD
N
-
---------------------------
-
-
R
T
N
Y
DA
Y
YSPGLP
LV
D
TR
K
L
YSQ
S
W
D
AG
L
RY
NG
EL
--I
K
S
Q
L
I
T
SY
----------
S
H
SK
DY
N
------------
-
Y
DPH
YG
RY
DS
S
A
TL
D
E
M
KQ
Y
T
V
-------------
QWAN
NII
IGHGNIGAGVDW--
-
-
Q
KQ
S
T
APG
T
A
Y
V
E
D
GYD
Q
R
N
TGIYL
T
G
L
Q
-------
Q
VGDF
T
F
EGAG
R
--------------
------
-----
SD
D
N
S
QF
GRHG
T
W
QT
SAG
W
E
F
I
E
G
Y
R
F
I
ASY
G
T
S
YK
APN
-------
L
G
Q
LY
G
SY
G
NP
N
L
N
P
E
KSKQ
W
E
GAFEGLTA
G
V
N
WR--
-
--
--
-
-
I
S
G
Y
R
N
D
V
S
DL
I
D
Y
D
--
D
H
T
L
K
YYNE
G
K
A
R
--------
I
KGVE
A
TA
N
FDT
G
P
LT
H
T
V
--
--
SY
D
Y
V
DA
R
--
-------
-
-
-
N
AI
T
D
T
P
LLRRA
K
QQ
VK
YQ
L
D
W
Q
L
Y
D
--
-
---
FD
W
G
ITYQYL
G
T
R
Y
DK
DY
S
S
Y
---
--
PY
Q
-
T
VK
M
--
G
G
V
S
L
W
DL
A
VA
Y
P
VT
S
----
HL
T
V
R
G
K
I
A
NLFDK
D
Y
E
T
-
--
--
-
VYG
YQ
-
T
A
G
R
E
Y
TL
X
G
S
Y
T
F
fig|656440.3.peg.4524
Escherichia coli TA206 (2-614/614)
IKK
AS
LL
T
A
C
S
V
-----
-
T
A
FS
---
-
-----
-
---
-
-
-
-
A
W
A
Q
D
TSP
D
T
LV
VTA
-
-
-
---
-
-
-
-
---
-
-
-
-
-
--
------
--
-
N
R
F
E
Q
P
RS
T
V
LA
P
T
TVV
T
R
Q
D
I
D
R
W
Q
ST
SV
N
D
VL
R
R
L
PGV
---
D
I
T
Q
N
G
G
S
G
Q
L
S
SIF
I
RG
T
------
NA
S
H
V
L
V
L
I
DG
V
R
L
NLAGV
SGSA
D
L
SQ
FP
I
AL
V
Q
RVE
Y
I
RGP
R
S
A
V
YG
SD
AI
GG
V
V
N
I
I
T
T
R
D
H
---
------------
P
G
T
EI
SA
G
W
GS
N
S
Y
QN
Y
DV
S
T
Q
QQ
L
G-
-
-
---
-----
--
--
-
-
-
-
-----
--
-
--
------
-
--
--
-
-
D
K
T
RV
T
L
L
G
DY
AHT
H
------
-
-
-
G
Y
DVVA
YG
NT
GT
Q
-----
AQ
P
D
--
--
--
--
--
-
---
NDG
FL
S
-------
K
T
L
YG
A
L
E
H
N
F
T
D
V
W
S--
-
-
--
---
-
-
--
-----
-
-
--
-------------------
GF
V
R
G
Y
G
YD
N
-
---------------------------
-
-
R
T
N
Y
DA
Y
YSPGLP
LV
D
TR
K
L
YSQ
S
W
D
AG
L
RY
NG
EL
--I
K
S
Q
L
I
SSY
----------
S
H
SK
DY
N
------------
-
Y
DPH
YG
RY
DS
S
A
TL
D
E
M
KQ
Y
T
V
-------------
QWAN
NII
IGHGNIGAGVDW--
-
-
Q
KQ
S
T
APG
T
A
Y
V
E
D
GYD
Q
R
N
TGIYL
T
G
L
Q
-------
Q
VGDF
T
F
EGAG
R
--------------
------
-----
SD
D
N
S
QF
GRHG
T
W
QT
SAG
W
E
F
I
E
G
Y
R
F
I
ASY
G
T
S
YK
APN
-------
L
G
Q
LY
G
TY
G
NP
N
L
N
P
E
KSKQ
W
E
GAFEGLTA
G
V
N
WR--
-
--
--
-
-
I
S
G
Y
R
N
D
V
S
DL
I
D
Y
D
--
D
H
T
L
K
YYNE
G
K
A
R
--------
I
KGVE
A
TA
N
FDT
G
P
LT
H
T
V
--
--
SY
D
Y
V
DA
R
--
-------
-
-
-
N
AI
T
D
T
P
LLRRA
K
QQ
VK
YQ
L
D
W
Q
L
Y
D
--
-
---
FD
W
G
ITYQYL
G
T
R
Y
DK
DY
S
S
Y
---
--
PY
Q
-
T
VK
M
--
G
G
V
S
L
W
DL
A
VA
Y
P
VT
S
----
HL
T
V
R
G
K
I
A
NLFDK
D
Y
E
T
-
--
--
-
VYG
YQ
-
T
A
G
R
E
Y
TL
S
G
S
Y
T
F
fig|340197.3.peg.2851
Escherichia coli F11 (2-614/614)
IKK
AS
LL
T
A
C
S
V
-----
-
T
A
FS
---
-
-----
-
---
-
-
-
-
A
W
A
Q
D
TSP
D
T
LV
VTA
-
-
-
---
-
-
-
-
---
-
-
-
-
-
--
------
--
-
N
R
F
E
Q
P
RS
T
V
LA
P
T
TVV
T
R
Q
D
I
D
R
W
Q
ST
SV
N
D
VL
R
R
L
PGV
---
D
I
T
Q
N
G
G
S
G
Q
L
S
SIF
I
RG
T
------
NA
S
H
V
L
V
L
I
DG
V
R
L
NLAGV
SGSA
D
L
SQ
FP
I
AL
V
Q
RVE
Y
I
RGP
R
S
A
V
YG
SD
AI
GG
V
V
N
I
I
T
T
R
D
H
---
------------
P
G
T
EI
SA
G
W
GS
N
S
Y
QN
Y
DV
S
T
Q
QQ
L
G-
-
-
---
-----
--
--
-
-
-
-
-----
--
-
--
------
-
--
--
-
-
D
N
T
RV
T
L
L
G
DY
AHT
H
------
-
-
-
G
Y
DVVA
YG
NT
GT
Q
-----
AQ
P
D
--
--
--
--
--
-
---
NDG
FL
S
-------
K
T
L
YG
A
L
E
H
N
F
T
D
V
W
S--
-
-
--
---
-
-
--
-----
-
-
--
-------------------
GF
V
R
G
Y
G
YD
N
-
---------------------------
-
-
R
T
N
Y
DA
Y
YSPGLP
LV
D
TR
K
L
YSQ
S
W
D
AG
L
RY
NG
EL
--I
K
S
Q
L
I
T
SY
----------
S
H
SK
DY
N
------------
-
Y
DPH
YG
RY
DS
S
A
TL
D
E
M
KQ
Y
T
V
-------------
QWAN
NII
IGHGNIGAGVDW--
-
-
Q
KQ
S
T
APG
T
A
Y
V
E
D
GYD
Q
R
N
TGIYL
T
G
L
Q
-------
Q
VGDF
T
F
EGAG
R
--------------
------
-----
SD
D
N
S
QF
GRHG
T
W
QT
SAG
W
E
F
I
E
G
Y
R
F
I
ASY
G
T
S
YK
APN
-------
L
G
Q
LY
G
SY
G
NP
N
L
N
P
E
KSKQ
W
E
GAFEGLTA
G
V
N
WR--
-
--
--
-
-
I
S
G
Y
R
N
D
V
S
DL
I
D
Y
D
--
D
H
T
L
K
YYNE
G
K
A
R
--------
I
KGVE
A
TA
N
FDT
G
P
LT
H
T
V
--
--
SY
D
Y
V
DA
R
--
-------
-
-
-
N
AI
T
D
T
P
LLRRA
K
QQ
VK
YQ
L
D
W
Q
L
Y
D
--
-
---
FD
W
G
ITYQYL
G
T
R
Y
DK
DY
S
S
Y
---
--
PY
Q
-
T
VK
M
--
G
G
V
S
L
W
DL
A
VA
Y
P
VT
S
----
HL
T
V
R
G
K
I
A
NLFDK
D
Y
E
T
-
--
--
-
VYG
YQ
-
T
A
G
R
E
Y
TL
S
G
S
Y
T
F
fig|340197.5.peg.2981
Escherichia coli F11 (2-614/614)
IKK
AS
LL
T
A
C
S
V
-----
-
T
A
FS
---
-
-----
-
---
-
-
-
-
A
W
A
Q
D
TSP
D
T
LV
VTA
-
-
-
---
-
-
-
-
---
-
-
-
-
-
--
------
--
-
N
R
F
E
Q
P
RS
T
V
LA
P
T
TVV
T
R
Q
D
I
D
R
W
Q
ST
SV
N
D
VL
R
R
L
PGV
---
D
I
T
Q
N
G
G
S
G
Q
L
S
SIF
I
RG
T
------
NA
S
H
V
L
V
L
I
DG
V
R
L
NLAGV
SGSA
D
L
SQ
FP
I
AL
V
Q
RVE
Y
I
RGP
R
S
A
V
YG
SD
AI
GG
V
V
N
I
I
T
T
R
D
H
---
------------
P
G
T
EI
SA
G
W
GS
N
S
Y
QN
Y
DV
S
T
Q
QQ
L
G-
-
-
---
-----
--
--
-
-
-
-
-----
--
-
--
------
-
--
--
-
-
D
N
T
RV
T
L
L
G
DY
AHT
H
------
-
-
-
G
Y
DVVA
YG
NT
GT
Q
-----
AQ
P
D
--
--
--
--
--
-
---
NDG
FL
S
-------
K
T
L
YG
A
L
E
H
N
F
T
D
V
W
S--
-
-
--
---
-
-
--
-----
-
-
--
-------------------
GF
V
R
G
Y
G
YD
N
-
---------------------------
-
-
R
T
N
Y
DA
Y
YSPGLP
LV
D
TR
K
L
YSQ
S
W
D
AG
L
RY
NG
EL
--I
K
S
Q
L
I
T
SY
----------
S
H
SK
DY
N
------------
-
Y
DPH
YG
RY
DS
S
A
TL
D
E
M
KQ
Y
T
V
-------------
QWAN
NII
IGHGNIGAGVDW--
-
-
Q
KQ
S
T
APG
T
A
Y
V
E
D
GYD
Q
R
N
TGIYL
T
G
L
Q
-------
Q
VGDF
T
F
EGAG
R
--------------
------
-----
SD
D
N
S
QF
GRHG
T
W
QT
SAG
W
E
F
I
E
G
Y
R
F
I
ASY
G
T
S
YK
APN
-------
L
G
Q
LY
G
SY
G
NP
N
L
N
P
E
KSKQ
W
E
GAFEGLTA
G
V
N
WR--
-
--
--
-
-
I
S
G
Y
R
N
D
V
S
DL
I
D
Y
D
--
D
H
T
L
K
YYNE
G
K
A
R
--------
I
KGVE
A
TA
N
FDT
G
P
LT
H
T
V
--
--
SY
D
Y
V
DA
R
--
-------
-
-
-
N
AI
T
D
T
P
LLRRA
K
QQ
VK
YQ
L
D
W
Q
L
Y
D
--
-
---
FD
W
G
ITYQYL
G
T
R
Y
DK
DY
S
S
Y
---
--
PY
Q
-
T
VK
M
--
G
G
V
S
L
W
DL
A
VA
Y
P
VT
S
----
HL
T
V
R
G
K
I
A
NLFDK
D
Y
E
T
-
--
--
-
VYG
YQ
-
T
A
G
R
E
Y
TL
S
G
S
Y
T
F
Consen1
Primary consensus
QFHSlTfikkiavm
st
f
-----
qa
---
l
-----
a
---
l
s
A
a
p
eTviVtasA
---
ap
d
dy
v
sT
------
sagTkmqmp
diPQsvtvVs
q
me
qQ
tl
Evl
ntpGv
---
-
k
gas
d
a
sRGF
------
dnym
--
dGi
t
wNlgDA
dm
-
al
ERvEvvRGp
s
myG
nPggaiNmV
Krat
------------
FkgdvsaeyGs
nk
y
D
q
L
dg
aRivG
qn
d
w
se
tf
------
fsg
D
-
Dlt
T
Lsag
q
------
p
wGg
----
lp
gT
-----
p
sydr
st
d
Ndg
n
--------
v
tlkh
FaDtwqat
n
hse
efd
-----
v
ay
-------------------
V
GtG
s
---------------------------
-
R
vda
-------
-
-
l
-
D
ldg
el
qh
LmfGg
----------
sysk
N
------------
ei
yg
gn
p
d
-
--
ysp
-------------
---
l
qdd
Th
-
ks
Yaad
l
D
lG
R
-------
Y
--
R
--------------
-----
ek
ht
----
Tp
Glvf
i
dnws
yaSYt
sFqP
---------
n
-
d
G
-
l
P
tgnnYE
-------
lGlK
n
lt
t
Aif
i
q
Nva
s
---
gt
i
Ge
r
--------
skGVE
eln
---
gAlt
nwql
sytyydAe
-------
G
-
a
pnlP
-----
rttvkmf
sY
l
vmP
---
LT
G
-----
gGvrw
--
svY
---
Py
-
tfr
--
GsYalvDlftrY
vtk
----
slqgnVnNLFDktY
tn
gsivYg
-
GapR
f
TgtyqF
Consen2
Secondary consensus
f
mfagas
v
ap
vnrdnq
sg
kps
-
lagci
-
lal
a
v
d
d
it
eg
-
t
-
e
g
-
p
a
iaarqsat
-
rtdtt
kv
pisi
t
e
ia
h
sv
am
yll
i
v
t
qgd
t
d
i
aaegq
nhsl
l
n
l
-
--
fp
ym
a
i
a
g
lt
sall
i
hph
lkev
q
ga
------
t
sl
t
s
t
-
y
lt
r
n
q
e
yaiapa
-
tw
a
kg
gy
-
ridvns
-
t
yygw
yg
n
s
--
pn
--
p
ek
dntysrnek
f
q
n
vftvr
-
aq
k
--
skmmy
-
sqvnkadgmlvgpysnygpgf
y
n
panayskq
caalapadkgh
l
--
ky
d
k
-
s
aqs
at
s
lt
v
d
mr
ryfsswanifpddy
fn
ds
a
n
wnl
fd
-
kq
-
m
-
g
vqt
w
t
qf
dd
qf
w
vny
f
gvt
if
s
i
sq
g
f
kskq
v
v
d
iv
-
y
l
k
nl
dp
ds
f
k
aykavdgtvar
tak
a
is
svn
gadrti
r
tdtty
nn
aqv
khmaslw
d
f
dg
sg
t
gny
dyrs
tdt
a
svk
eq
g
va
alva
larvgma
valh
a
re
as
--
nt
-
w
te
v
asf
Consensus 1
(when a gap)
Conservative difference
Consensus 2
(when a gap)
Nonconservative diff.
Other character