fig|1040638.4.peg.442
Escherichia coli O104:H4 str. LB226692
MGW
LVMA
V
G
L
T
I
LI
I
T
GS
Y
QNQKM
SET
TNAQ
Q
Y
A
SAS
V
W
A
SQ
IL
MI
AN
R
IND
IR
Y
VS
G
QQ
-
--
D
G
V
IS
S
D
K
L
A
LP
V
T
PD
SR
I
K
H
Q
L
Q
Q
G
R
L
WVW
MP
E
Q
PGL
V
E
T
L
RL
K
S
RG
SALIG
IF
QNGQL
T
W
LS
G
TAT
GLT
P
PA
G
I
T
AGS
V
V
Y
VN
fig|6666666.5357.peg.2820
Escherichia coli TY-2482
MGW
LVMA
V
G
L
T
I
LI
I
T
GS
Y
QNQKM
SET
TNAQ
Q
Y
A
SAS
V
W
A
SQ
IL
MI
AN
R
IND
IR
Y
VS
G
QQ
-
--
D
G
V
IS
S
D
K
L
A
LP
V
T
PD
SR
I
K
H
Q
L
Q
Q
G
R
L
WVW
MP
E
Q
PGL
V
E
T
L
RL
K
S
RG
SALIG
IF
QNGQL
T
W
LS
G
TAT
GLT
P
PA
G
I
T
AGS
V
V
Y
VN
fig|595495.4.peg.3700
Escherichia coli KO11
MGW
LVMA
V
G
L
T
I
LI
I
T
GS
Y
QNQKM
SET
TNAQ
Q
Y
A
SAS
V
W
A
SQ
IL
MI
AN
R
IND
IR
Y
VS
G
QQ
-
--
D
G
V
IS
S
D
K
L
A
LP
V
T
PD
SR
I
K
H
Q
L
Q
Q
G
R
L
WVW
MP
E
Q
PGL
V
E
T
L
RS
K
S
RG
SALIG
IF
QNGQL
T
W
LS
G
TAT
GLT
P
PA
G
I
T
AGS
V
V
Y
VN
fig|679207.4.peg.4573
Escherichia coli MS 107-1
MGW
LVMA
V
G
L
T
I
LI
I
T
GS
Y
QNQKM
SET
TNAQ
Q
Y
A
SAS
V
W
A
SQ
IL
MI
AN
R
IND
IR
Y
VS
G
QQ
-
--
D
G
V
IS
S
D
K
L
A
LP
V
T
PD
SR
I
K
H
Q
L
Q
Q
G
R
L
WVW
MP
E
Q
PGL
V
E
T
L
RS
K
S
RG
SALIG
IF
QNGQL
T
W
LS
G
TAT
GLT
P
PA
G
I
T
AGS
V
V
Y
VN
fig|679205.4.peg.5007
Escherichia coli MS 124-1
MGW
LVMA
V
G
L
T
I
LI
I
T
GS
Y
QNQKM
SET
TNAQ
Q
Y
A
SAS
V
W
A
SQ
IL
MI
AN
R
IND
IR
Y
VS
G
QQ
-
--
D
G
V
IS
S
D
K
L
A
LP
V
T
PD
SR
I
K
H
Q
L
Q
Q
G
R
L
WVW
MP
E
Q
PGL
V
E
T
L
RS
K
S
RG
SALIG
IF
QNGQL
T
W
LS
G
TAT
GLT
P
PA
G
I
T
AGS
V
V
Y
VN
fig|749533.3.peg.5239
Escherichia coli MS 84-1
MGW
LVMA
V
G
L
T
I
LI
I
T
GS
Y
QNQKM
SET
TNAQ
Q
Y
A
SAS
V
W
A
SQ
IL
MI
AN
R
IND
IR
Y
VS
G
QQ
-
--
D
G
V
IS
S
D
K
L
A
LP
V
T
PD
SR
I
K
H
Q
L
Q
Q
G
R
L
WVW
MP
E
Q
PGL
V
E
T
L
RS
K
S
RG
SALIG
IF
QNGQL
T
W
LS
G
TAT
GLT
P
PA
G
I
T
AGS
V
V
Y
VN
fig|444454.5.peg.425
Escherichia coli O157:H7 str. EC4024
MGW
LVMA
V
G
L
T
I
LI
I
T
GS
Y
QNQKM
SET
TNAQ
Q
Y
A
SAS
V
W
A
SQ
IL
MI
AN
R
IND
IR
Y
VS
G
QQ
-
--
D
G
V
IS
S
D
K
L
A
LP
V
T
PD
SR
I
K
H
Q
L
Q
Q
G
R
L
WVW
MP
E
Q
PGL
V
E
T
L
RS
K
S
RG
SALIG
IF
QNGQL
T
W
LS
G
TAT
GLT
P
PA
G
I
T
AGS
V
V
Y
VN
fig|478004.5.peg.4959
Escherichia coli O157:H7 str. EC4401
MGW
LVMA
V
G
L
T
I
LI
I
T
GS
Y
QNQKM
SET
TNAQ
Q
Y
A
SAS
V
W
A
SQ
IL
MI
AN
R
IND
IR
Y
VS
G
QQ
-
--
D
G
V
IS
S
D
K
L
A
LP
V
T
PD
SR
I
K
H
Q
L
Q
Q
G
R
L
WVW
MP
E
Q
PGL
V
E
T
L
RS
K
S
RG
SALIG
IF
QNGQL
T
W
LS
G
TAT
GLT
P
PA
G
I
T
AGS
V
V
Y
VN
fig|566546.3.peg.3411
Escherichia coli W
MGW
LVMA
V
G
L
T
I
LI
I
T
GS
Y
QNQKM
SET
TNAQ
Q
Y
A
SAS
V
W
A
SQ
IL
MI
AN
R
IND
IR
Y
VS
G
QQ
-
--
D
G
V
IS
S
D
K
L
A
LP
V
T
PD
SR
I
K
H
Q
L
Q
Q
G
R
L
WVW
MP
E
Q
PGL
V
E
T
L
RS
K
S
RG
SALIG
IF
QNGQL
T
W
LS
G
TAT
GLT
P
PA
G
I
T
AGS
V
V
Y
VN
fig|566546.4.peg.4767
Escherichia coli W
MGW
LVMA
V
G
L
T
I
LI
I
T
GS
Y
QNQKM
SET
TNAQ
Q
Y
A
SAS
V
W
A
SQ
IL
MI
AN
R
IND
IR
Y
VS
G
QQ
-
--
D
G
V
IS
S
D
K
L
A
LP
V
T
PD
SR
I
K
H
Q
L
Q
Q
G
R
L
WVW
MP
E
Q
PGL
V
E
T
L
RS
K
S
RG
SALIG
IF
QNGQL
T
W
LS
G
TAT
GLT
P
PA
G
I
T
AGS
V
V
Y
VN
fig|331111.12.peg.197
Escherichia coli E24377A
MGW
LVMA
V
G
L
T
I
LI
I
T
GS
Y
QNQQM
SET
TNAQ
Q
Y
A
SAS
V
W
A
SQ
IL
MI
AN
R
IND
IR
Y
VS
G
QQ
-
--
D
G
V
IS
S
D
K
L
A
LP
V
T
PD
SR
I
K
H
Q
L
Q
Q
G
R
L
WVW
MP
E
Q
PGL
V
E
T
L
RS
K
S
RG
SALIG
IF
QNGQL
T
W
LS
G
TAT
GLT
P
PA
G
I
T
AGS
V
V
Y
VN
fig|409438.11.peg.5042
Escherichia coli SE11
MGW
LVMA
V
G
L
T
I
LI
I
T
GS
Y
QNQQM
SET
TNAQ
Q
Y
A
GAS
V
W
A
SQ
IL
MI
AN
R
IND
IR
Y
VS
G
QQ
-
--
D
G
V
IS
S
D
I
L
A
LP
V
T
PD
SR
I
K
H
Q
L
Q
Q
G
R
L
WVW
MP
E
Q
PGL
V
E
T
L
RS
K
S
RG
SALIG
IF
QNGQL
T
W
LS
G
TAT
GLT
P
PA
G
I
T
AGS
V
V
Y
VN
fig|340184.3.peg.1329
Escherichia coli B7A
MGW
VTGF
I
-
M
V
I
MA
IG
NF
W
FHSHL
S
R
T
VHHQ
Q
T
A
EIT
Q
Q
A
AD
FI
RY
M
N
A
INDYLY
QH
P
ER
R
AA
GG
Q
LTS
A
QLGLP
A
T
KN
--
V
S
H
L
I
S
Q
Q
RV
F
VW
AK
E
K
PGLM
G
AL
LE
QS
GD
SAL
LA
RV
E
NG
R
L
L
D
TH
G
RRI
S
I
T
L
PA
V
IP
DQV
I
I
W
M
N
fig|340184.6.peg.1399
Escherichia coli B7A
MGW
VTGF
I
-
M
V
I
MA
IG
NF
W
FHSHL
S
R
T
VHHQ
Q
T
A
EIT
Q
Q
A
AD
FI
RY
M
N
A
INDYLY
QH
P
ER
R
AA
GG
Q
LTS
A
QLGLP
A
T
KN
--
V
S
H
L
I
S
Q
Q
RV
F
VW
AK
E
K
PGLM
G
AL
LE
QS
GD
SAL
LA
RV
E
NG
R
L
L
D
TH
G
RRI
S
I
T
L
PA
V
IP
DQV
I
I
W
M
N
fig|749548.3.peg.5343
Escherichia coli MS 196-1
MGW
VTGF
I
-
M
V
I
MA
IG
NF
W
FHSHL
S
R
T
VHHQ
Q
T
A
EIT
Q
Q
A
AD
FI
RY
M
N
A
INDYLY
QH
P
ER
R
AA
GG
Q
LTS
A
QLGLP
A
T
KN
--
V
S
H
L
I
S
Q
Q
RV
F
VW
AK
E
K
PGLM
G
AL
LE
QS
GD
SAL
LA
RV
E
NG
R
L
L
D
TR
G
RRI
S
I
T
L
PA
V
IP
DQV
I
I
W
M
N
fig|749550.3.peg.4118
Escherichia coli MS 200-1
MGW
VTGF
I
-
M
V
I
MA
IG
NF
W
FHSHL
S
R
T
VHHQ
Q
T
A
EIT
Q
Q
A
AD
FI
RY
M
N
A
INDYLY
QH
P
ER
R
AA
GG
Q
LTS
A
QLGLP
A
T
KN
--
V
S
H
L
I
S
Q
Q
RV
F
VW
AK
E
K
PGLM
G
AL
LE
QS
GD
SAL
LA
RV
E
NG
R
L
L
D
TR
G
RRI
S
I
T
L
PA
V
IP
DQV
I
I
W
M
N
fig|749527.3.peg.4675
Escherichia coli MS 21-1
MGW
VTGF
I
-
M
V
I
MA
IG
NF
W
FHSHL
S
R
T
VHHQ
Q
T
A
EIT
Q
Q
A
AD
FI
RY
M
N
A
INDYLY
QH
P
ER
R
AA
GG
Q
LTS
A
QLGLP
A
T
KN
--
V
S
H
L
I
S
Q
Q
RV
F
VW
AK
E
K
PGLM
G
AL
LE
QS
GD
SAL
LA
RV
E
NG
R
L
L
D
TR
G
RRI
S
I
T
L
PA
V
IP
DQV
I
I
W
M
N
fig|478005.5.peg.4322
Escherichia coli O157:H7 str. EC4486
MGW
VTGF
I
-
M
V
I
MA
IG
NF
W
FHSHL
S
R
T
VHHQ
Q
T
A
EIT
Q
Q
A
AD
FI
RY
M
N
A
INDYLY
QH
P
ER
R
AA
GG
Q
LTS
A
QLGLP
A
T
KN
--
V
S
H
L
I
S
Q
Q
RV
F
VW
AK
E
K
PGLM
G
AL
LE
QS
GD
SAL
LA
RV
E
NG
R
L
L
D
TR
G
RRI
S
I
T
L
PA
V
IP
DQV
I
I
W
M
N
fig|585397.6.peg.278
Escherichia coli ED1a
MGW
FIVF
I
-
M
V
I
TT
T
G
NF
W
FTSQL
S
R
S
EHRY
Q
A
A
ENT
Q
Q
A
AT
FI
RY
M
N
A
INDYL
H
QH
P
ER
R
TA
GG
R
LTS
A
QLGLP
G
T
DT
--
V
S
H
I
I
S
Q
Q
RV
F
VW
AT
E
T
PGLM
A
AL
RE
QS
ND
SAL
L
GRV
E
NG
R
L
L
D
TA
G
RAL
S
V
T
L
P
S
V
IP
DHV
I
L
W
M
N
fig|585397.9.peg.5380
Escherichia coli ED1a
MGW
FIVF
I
-
M
V
I
TT
T
G
NF
W
FTSQL
S
R
S
EHRY
Q
A
A
ENT
Q
Q
A
AT
FI
RY
M
N
A
INDYL
H
QH
P
ER
R
TA
GG
R
LTS
A
QLGLP
G
T
DT
--
V
S
H
I
I
S
Q
Q
RV
F
VW
AT
E
T
PGLM
A
AL
RE
QS
ND
SAL
L
GRV
E
NG
R
L
L
D
TA
G
RAL
S
V
T
L
P
S
V
IP
DHV
I
L
W
M
N
fig|656393.3.peg.25
Escherichia coli H299
MGW
FIVF
I
-
M
V
I
TT
T
G
NF
W
FTSQL
S
R
S
EHRH
Q
A
A
ENT
Q
Q
A
AT
FI
RY
M
N
A
INDYL
H
QH
P
ER
R
TA
GG
R
LTS
A
QLG
I
P
G
T
DT
--
V
S
H
I
I
S
Q
Q
RV
F
VW
AT
E
T
PGLM
A
AL
RE
QS
ND
SAL
L
GRV
E
NG
R
L
L
D
TA
G
RAL
S
V
T
L
P
S
V
IP
DHV
I
L
W
M
N
fig|637388.3.peg.3460
Escherichia coli O157:H7 str. FRIK2000
MGW
FFSL
L
-
L
I
F
LS
IG
SY
Y
LTDNN
N
Q
T
IQRM
K
L
L
PAK
Q
E
A
IE
FI
HF
AN
V
INDYLY
KY
P
D
K
R
NS
GG
T
LTS
E
Q
I
G
IT
P
V
YD
--
I
H
H
I
I
Y
G
K
RV
Y
I
W
SA
D
T
E
GLM
S
AL
QQ
Q
T
KH
SA
ML
GRV
K
N
K
K
I
I
D
NQ
G
NDM
G
V
T
I
P
S
S
IP
EGS
IV
F
I
N
fig|749540.3.peg.1225
Escherichia coli MS 146-1
MGW
FFSL
L
-
L
I
F
LS
IG
SY
Y
LTDNN
N
Q
T
IQRM
K
L
L
PAK
Q
E
A
IE
F
V
HF
AN
V
INDYLY
KY
P
D
K
R
NS
GG
T
LTS
E
Q
I
G
IT
P
V
YD
--
I
H
H
I
I
Y
G
K
RV
Y
I
W
SA
D
T
E
GLM
S
AL
QQ
Q
T
KH
SA
ML
GRV
K
N
K
K
I
V
D
NQ
G
NDM
G
V
T
I
P
S
S
IP
EGS
IV
F
I
N
fig|562.373.peg.654
Escherichia coli 1125A
MGW
FFSL
L
-
L
I
F
LS
IG
SY
Y
LTDNN
N
Q
T
IQRM
K
L
L
PAK
Q
E
A
IE
FI
HF
AN
V
INDYLY
KY
P
D
K
R
NS
GG
T
LTS
E
Q
I
G
IT
P
V
YD
--
I
H
H
I
I
Y
G
K
RV
Y
I
W
SA
D
T
E
GLM
S
AL
QQ
Q
T
KH
SA
ML
GRV
K
N
K
K
I
V
D
NQ
G
NDM
G
V
P
V
P
S
S
IP
EEA
IV
L
I
N
fig|562.375.peg.5417
Escherichia coli EC4100B
MGW
FFSL
L
-
L
I
F
LS
IG
SY
Y
LTDNN
N
Q
T
IQRM
K
L
L
PAK
Q
E
A
IE
F
V
HF
AN
V
INDYLY
KY
P
D
K
R
NS
GG
T
LTS
E
Q
I
G
IT
P
V
YD
--
I
H
H
I
I
Y
G
K
RV
Y
I
W
SA
D
T
E
GLM
S
AL
QQ
Q
T
KH
SA
ML
GRV
K
N
K
K
I
V
D
NQ
G
NDM
G
V
P
V
P
S
S
IP
EEA
IV
L
I
N
fig|585397.7.peg.3508
Escherichia coli ED1a (3-136/136)
L
FI
IG
NW
F
HAGNT
ERA
IKNT
D
E
Q
QRQ
Q
Q
V
YE
IL
RL
T
N
A
IND
W
K
Y
HH
P
GDI
RE
G
K
M
LT
V
N
E
T
G
FA
P
V
YG
--
T
K
H
I
I
S
G
Q
R
T
F
VW
LP
F
Q
PGL
I
S
AL
NE
V
S
RN
SALI
A
Q
V
RD
R
K
L
L
D
NQ
G
NNI
G
V
P
-
P
S
V
IP
ENA
IV
L
I
N
fig|585397.9.peg.3504
Escherichia coli ED1a (3-136/136)
L
FI
IG
NW
F
HAGNT
ERA
IKNT
D
E
Q
QRQ
Q
Q
V
YE
IL
RL
T
N
A
IND
W
K
Y
HH
P
GDI
RE
G
K
M
LT
V
N
E
T
G
FA
P
V
YG
--
T
K
H
I
I
S
G
Q
R
T
F
VW
LP
F
Q
PGL
I
S
AL
NE
V
S
RN
SALI
A
Q
V
RD
R
K
L
L
D
NQ
G
NNI
G
V
P
-
P
S
V
IP
ENA
IV
L
I
N
Consen1
Primary consensus
MGW
v
-
l
i
ig
y
set
q
a
q
A
il
aN
INDyly
pqqr
gG
ltS
qlglp
t
--
i
H
i
q
RvwvW
e
pGLm
aL
qs
SAligrvqNgql
d
G
glt
Pa
Ip
iv
vN
Consen2
Secondary consensus
gm
f
tt
w
n
s
k
l
v
fi
m
irh
g
-
d
is
iait
v
srv
l
g
l
i
d
e
v
t
kt
mlaif
k
i
w
s
p
s
t
v
Consensus 1
(when a gap)
Conservative difference
Consensus 2
(when a gap)
Nonconservative diff.
Other character