fig|1040638.4.peg.4273
Escherichia coli O104:H4 str. LB226692
MKTLNRRDFPGAQ
Y
P
E
RI
IQ
FG
E
G
N
F
L
RA
FVDW
Q
I
D
L
L
N
E
H
TD
L
NS
G
VVV
V
R
P
IE
T
S
-
--
F
PPS
L
ST
Q
DG
LYT
T
I
IRGLN
EKG
E
AV
SDA
R
L
I
R
SV
N
REI
S
V
Y
S
E
Y
D
E---
F
L
KLAHN
P
E
M
RF
V
FSN
T
TE
A
G
IS
Y
H
-
A
G
D
K
F
D
-
D
A
P
A
V
S
Y
--
-
--
--
P
A
KL
T
R
L
L
F
E
RF
SH
FNG
A
LD
K
G
WII
I
P
C
EL
I
DY
NG
DA
L
R
E
L
VL
R
Y
AQ
E
W
A
L
PE
AFI
Q
W
L
D
Q
A
N
SF
C
S
T
L
VDRIV
TGYP
R
D
E
V
A
KL
E
E
E
LG
Y
HD
GFLD
T
A
E
H
F
Y
LF
VI
QGPKSLATELRL
D
KY
-
-
---
-
-
-PL
N
V
L
I
V
D
D
I
K
PY
K
E
R
K
VAI
LNG
A
H
TA
L
VPVAFQ
A
G
LD
T
V
G
E
A
M
N
D
AEI
C
A
FV
EK
AI
Y
EE
II
P
V
L
D
LP
R
-
D
E
L
ES
F
A
SA
VT
G
RF
R
NP
Y
I
KHQ
LLS
IA
LN
G
MT
K
FRTRI
LPQ
-
LLAG
Q
K
-
--
A
K
GT
L
P
AR
L
TFAL
A
ALIAF
YR
G
-
E
RN
G
ETYP
V
Q
D
D
A
HW
L
E
R
Y
QQL
W
S
Q
HR
DRVIG
TQ
E
L
V
A
IV
L
A
E
KDH
W
E
Q
DL
T
Q
V
P
G
L
V
E
Q
V
AN
D
L
DA
I
L
E
K
G
M
REAVR
P
LC
fig|6666666.5357.peg.2881
Escherichia coli TY-2482
MKTLNRRDFPGAQ
Y
P
E
RI
IQ
FG
E
G
N
F
L
RA
FVDW
Q
I
D
L
L
N
E
H
TD
L
NS
G
VVV
V
R
P
IE
T
S
-
--
F
PPS
L
ST
Q
DG
LYT
T
I
IRGLN
EKG
E
AV
SDA
R
L
I
R
SV
N
REI
S
V
Y
S
E
Y
D
E---
F
L
KLAHN
P
E
M
RF
V
FSN
T
TE
A
G
IS
Y
H
-
A
G
D
K
F
D
-
D
A
P
A
V
S
Y
--
-
--
--
P
A
KL
T
R
L
L
F
E
RF
SH
FNG
A
LD
K
G
WII
I
P
C
EL
I
DY
NG
DA
L
R
E
L
VL
R
Y
AQ
E
W
A
L
PE
AFI
Q
W
L
D
Q
A
N
SF
C
S
T
L
VDRIV
TGYP
R
D
E
V
A
KL
E
E
E
LG
Y
HD
GFLD
T
A
E
H
F
Y
LF
VI
QGPKSLATELRL
D
KY
-
-
---
-
-
-PL
N
V
L
I
V
D
D
I
K
PY
K
E
R
K
VAI
LNG
A
H
TA
L
VPVAFQ
A
G
LD
T
V
G
E
A
M
N
D
AEI
C
A
FV
EK
AI
Y
EE
II
P
V
L
D
LP
R
-
D
E
L
ES
F
A
SA
VT
G
RF
R
NP
Y
I
KHQ
LLS
IA
LN
G
MT
K
FRTRI
LPQ
-
LLAG
Q
K
-
--
A
K
GT
L
P
AR
L
TFAL
A
ALIAF
YR
G
-
E
RN
G
ETYP
V
Q
D
D
A
HW
L
E
R
Y
QQL
W
S
Q
HR
DRVIG
TQ
E
L
V
A
IV
L
A
E
KDH
W
E
Q
DL
T
Q
V
P
G
L
V
E
Q
V
AN
D
L
DA
I
L
E
K
G
M
REAVR
P
LC
fig|670888.3.peg.2220
Escherichia coli 1827-70
MKTLNRRDFPGAQ
Y
P
E
RI
IQ
FG
E
G
N
F
L
RA
FVDW
Q
I
D
L
L
N
E
H
TD
L
NS
G
VVV
V
R
P
IE
T
S
-
--
F
PPS
L
ST
Q
DG
LYT
T
I
IRGLN
EKG
E
AV
SDA
R
L
I
R
SV
N
REI
S
V
Y
S
E
Y
D
E---
F
L
KLAHN
P
E
M
RF
V
FSN
T
TE
A
G
IS
Y
H
-
A
G
D
K
F
D
-
D
A
P
A
V
S
Y
--
-
--
--
P
A
KL
T
R
L
L
F
E
RF
SH
FNG
A
LD
K
G
WII
I
P
C
EL
I
DY
NG
DA
L
R
E
L
VL
R
Y
AQ
E
W
A
L
PE
AFI
Q
W
L
D
Q
A
N
SF
C
S
T
L
VDRIV
TGYP
R
D
E
V
A
KL
E
E
E
LG
Y
HD
GFLD
T
A
E
H
F
Y
LF
VI
QGPKSLATELRL
D
KY
-
-
---
-
-
-PL
N
V
L
I
V
D
D
I
K
PY
K
E
R
K
VAI
LNG
A
H
TA
L
VPVAFQ
A
G
LD
T
V
G
E
A
M
N
D
AEI
C
A
FV
EK
AI
Y
EE
II
P
V
L
D
LP
R
-
D
E
L
ES
F
A
SA
VT
G
RF
R
NP
Y
I
KHQ
LLS
IA
LN
G
MT
K
FRTRI
LPQ
-
LLAG
Q
K
-
--
A
K
GT
L
P
AR
L
TFAL
A
ALIAF
YR
G
-
E
RN
G
ETYP
V
Q
D
D
A
HW
L
E
R
Y
QQL
W
S
Q
HR
DRVIG
TQ
E
L
V
A
IV
L
A
E
KDH
W
E
Q
DL
T
Q
V
P
G
L
V
E
Q
V
AN
D
L
DA
I
L
E
K
G
M
REAVR
P
LC
fig|585055.6.peg.1682
Escherichia coli 55989
MKTLNRRDFPGAQ
Y
P
E
RI
IQ
FG
E
G
N
F
L
RA
FVDW
Q
I
D
L
L
N
E
H
TD
L
NS
G
VVV
V
R
P
IE
T
S
-
--
F
PPS
L
ST
Q
DG
LYT
T
I
IRGLN
EKG
E
AV
SDA
R
L
I
R
SV
N
REI
S
V
Y
S
E
Y
D
E---
F
L
KLAHN
P
E
M
RF
V
FSN
T
TE
A
G
IS
Y
H
-
A
G
D
K
F
D
-
D
A
P
A
V
S
Y
--
-
--
--
P
A
KL
T
R
L
L
F
E
RF
SH
FNG
A
LD
K
G
WII
I
P
C
EL
I
DY
NG
DA
L
R
E
L
VL
R
Y
AQ
E
W
A
L
PE
AFI
Q
W
L
D
Q
A
N
SF
C
S
T
L
VDRIV
TGYP
R
D
E
V
A
KL
E
E
E
LG
Y
HD
GFLD
T
A
E
H
F
Y
LF
VI
QGPKSLATELRL
D
KY
-
-
---
-
-
-PL
N
V
L
I
V
D
D
I
K
PY
K
E
R
K
VAI
LNG
A
H
TA
L
VPVAFQ
A
G
LD
T
V
G
E
A
M
N
D
AEI
C
A
FV
EK
AI
Y
EE
II
P
V
L
D
LP
R
-
D
E
L
ES
F
A
SA
VT
G
RF
R
NP
Y
I
KHQ
LLS
IA
LN
G
MT
K
FRTRI
LPQ
-
LLAG
Q
K
-
--
A
K
GT
L
P
AR
L
TFAL
A
ALIAF
YR
G
-
E
RN
G
ETYP
V
Q
D
D
A
HW
L
E
R
Y
QQL
W
S
Q
HR
DRVIG
TQ
E
L
V
A
IV
L
A
E
KDH
W
E
Q
DL
T
Q
V
P
G
L
V
E
Q
V
AN
D
L
DA
I
L
E
K
G
M
REAVR
P
LC
fig|585055.8.peg.1686
Escherichia coli 55989
MKTLNRRDFPGAQ
Y
P
E
RI
IQ
FG
E
G
N
F
L
RA
FVDW
Q
I
D
L
L
N
E
H
TD
L
NS
G
VVV
V
R
P
IE
T
S
-
--
F
PPS
L
ST
Q
DG
LYT
T
I
IRGLN
EKG
E
AV
SDA
R
L
I
R
SV
N
REI
S
V
Y
S
E
Y
D
E---
F
L
KLAHN
P
E
M
RF
V
FSN
T
TE
A
G
IS
Y
H
-
A
G
D
K
F
D
-
D
A
P
A
V
S
Y
--
-
--
--
P
A
KL
T
R
L
L
F
E
RF
SH
FNG
A
LD
K
G
WII
I
P
C
EL
I
DY
NG
DA
L
R
E
L
VL
R
Y
AQ
E
W
A
L
PE
AFI
Q
W
L
D
Q
A
N
SF
C
S
T
L
VDRIV
TGYP
R
D
E
V
A
KL
E
E
E
LG
Y
HD
GFLD
T
A
E
H
F
Y
LF
VI
QGPKSLATELRL
D
KY
-
-
---
-
-
-PL
N
V
L
I
V
D
D
I
K
PY
K
E
R
K
VAI
LNG
A
H
TA
L
VPVAFQ
A
G
LD
T
V
G
E
A
M
N
D
AEI
C
A
FV
EK
AI
Y
EE
II
P
V
L
D
LP
R
-
D
E
L
ES
F
A
SA
VT
G
RF
R
NP
Y
I
KHQ
LLS
IA
LN
G
MT
K
FRTRI
LPQ
-
LLAG
Q
K
-
--
A
K
GT
L
P
AR
L
TFAL
A
ALIAF
YR
G
-
E
RN
G
ETYP
V
Q
D
D
A
HW
L
E
R
Y
QQL
W
S
Q
HR
DRVIG
TQ
E
L
V
A
IV
L
A
E
KDH
W
E
Q
DL
T
Q
V
P
G
L
V
E
Q
V
AN
D
L
DA
I
L
E
K
G
M
REAVR
P
LC
fig|481805.3.peg.2298
Escherichia coli ATCC 8739
MKTLNRRDFPGAQ
Y
P
E
RI
IQ
FG
E
G
N
F
L
RA
FVDW
Q
I
D
L
L
N
E
H
TD
L
NS
G
VVV
V
R
P
IE
T
S
-
--
F
PPS
L
ST
Q
DG
LYT
T
I
IRGLN
EKG
E
AV
SDA
R
L
I
R
SV
N
REI
S
V
Y
S
E
Y
D
E---
F
L
KLAHN
P
E
M
RF
V
FSN
T
TE
A
G
IS
Y
H
-
A
G
D
K
F
D
-
D
A
P
A
V
S
Y
--
-
--
--
P
A
KL
T
R
L
L
F
E
RF
SH
FNG
A
LD
K
G
WII
I
P
C
EL
I
DY
NG
DA
L
R
E
L
VL
R
Y
AQ
E
W
A
L
PE
AFI
Q
W
L
D
Q
A
N
SF
C
S
T
L
VDRIV
TGYP
R
D
E
V
A
KL
E
E
E
LG
Y
HD
GFLD
T
A
E
H
F
Y
LF
VI
QGPKSLATELRL
D
KY
-
-
---
-
-
-PL
N
V
L
I
V
D
D
I
K
PY
K
E
R
K
VAI
LNG
A
H
TA
L
VPVAFQ
A
G
LD
T
V
G
E
A
M
N
D
AEI
C
A
FV
EK
AI
Y
EE
II
P
V
L
D
LP
R
-
D
E
L
ES
F
A
SA
VT
G
RF
R
NP
Y
I
KHQ
LLS
IA
LN
G
MT
K
FRTRI
LPQ
-
LLAG
Q
K
-
--
A
K
GT
L
P
AR
L
TFAL
A
ALIAF
YR
G
-
E
RN
G
ETYP
V
Q
D
D
A
HW
L
E
R
Y
QQL
W
S
Q
HR
DRVIG
TQ
E
L
V
A
IV
L
A
E
KDH
W
E
Q
DL
T
Q
V
P
G
L
V
E
Q
V
AN
D
L
DA
I
L
E
K
G
M
REAVR
P
LC
fig|481805.6.peg.2289
Escherichia coli ATCC 8739
MKTLNRRDFPGAQ
Y
P
E
RI
IQ
FG
E
G
N
F
L
RA
FVDW
Q
I
D
L
L
N
E
H
TD
L
NS
G
VVV
V
R
P
IE
T
S
-
--
F
PPS
L
ST
Q
DG
LYT
T
I
IRGLN
EKG
E
AV
SDA
R
L
I
R
SV
N
REI
S
V
Y
S
E
Y
D
E---
F
L
KLAHN
P
E
M
RF
V
FSN
T
TE
A
G
IS
Y
H
-
A
G
D
K
F
D
-
D
A
P
A
V
S
Y
--
-
--
--
P
A
KL
T
R
L
L
F
E
RF
SH
FNG
A
LD
K
G
WII
I
P
C
EL
I
DY
NG
DA
L
R
E
L
VL
R
Y
AQ
E
W
A
L
PE
AFI
Q
W
L
D
Q
A
N
SF
C
S
T
L
VDRIV
TGYP
R
D
E
V
A
KL
E
E
E
LG
Y
HD
GFLD
T
A
E
H
F
Y
LF
VI
QGPKSLATELRL
D
KY
-
-
---
-
-
-PL
N
V
L
I
V
D
D
I
K
PY
K
E
R
K
VAI
LNG
A
H
TA
L
VPVAFQ
A
G
LD
T
V
G
E
A
M
N
D
AEI
C
A
FV
EK
AI
Y
EE
II
P
V
L
D
LP
R
-
D
E
L
ES
F
A
SA
VT
G
RF
R
NP
Y
I
KHQ
LLS
IA
LN
G
MT
K
FRTRI
LPQ
-
LLAG
Q
K
-
--
A
K
GT
L
P
AR
L
TFAL
A
ALIAF
YR
G
-
E
RN
G
ETYP
V
Q
D
D
A
HW
L
E
R
Y
QQL
W
S
Q
HR
DRVIG
TQ
E
L
V
A
IV
L
A
E
KDH
W
E
Q
DL
T
Q
V
P
G
L
V
E
Q
V
AN
D
L
DA
I
L
E
K
G
M
REAVR
P
LC
fig|340186.3.peg.104
Escherichia coli E110019
MKTLNRRDFPGAQ
Y
P
E
RI
IQ
FG
E
G
N
F
L
RA
FVDW
Q
I
D
L
L
N
E
H
TD
L
NS
G
VVV
V
R
P
IE
T
S
-
--
F
PPS
L
ST
Q
DG
LYT
T
I
IRGLN
EKG
E
AV
SDA
R
L
I
R
SV
N
REI
S
V
Y
S
E
Y
D
E---
F
L
KLAHN
P
E
M
RF
V
FSN
T
TE
A
G
IS
Y
H
-
A
G
D
K
F
D
-
D
A
P
A
V
S
Y
--
-
--
--
P
A
KL
T
R
L
L
F
E
RF
SH
FNG
A
LD
K
G
WII
I
P
C
EL
I
DY
NG
DA
L
R
E
L
VL
R
Y
AQ
E
W
A
L
PE
AFI
Q
W
L
D
Q
A
N
SF
C
S
T
L
VDRIV
TGYP
R
D
E
V
A
KL
E
E
E
LG
Y
HD
GFLD
T
A
E
H
F
Y
LF
VI
QGPKSLATELRL
D
KY
-
-
---
-
-
-PL
N
V
L
I
V
D
D
I
K
PY
K
E
R
K
VAI
LNG
A
H
TA
L
VPVAFQ
A
G
LD
T
V
G
E
A
M
N
D
AEI
C
A
FV
EK
AI
Y
EE
II
P
V
L
D
LP
R
-
D
E
L
ES
F
A
SA
VT
G
RF
R
NP
Y
I
KHQ
LLS
IA
LN
G
MT
K
FRTRI
LPQ
-
LLAG
Q
K
-
--
A
K
GT
L
P
AR
L
TFAL
A
ALIAF
YR
G
-
E
RN
G
ETYP
V
Q
D
D
A
HW
L
E
R
Y
QQL
W
S
Q
HR
DRVIG
TQ
E
L
V
A
IV
L
A
E
KDH
W
E
Q
DL
T
Q
V
P
G
L
V
E
Q
V
AN
D
L
DA
I
L
E
K
G
M
REAVR
P
LC
fig|340186.5.peg.117
Escherichia coli E110019
MKTLNRRDFPGAQ
Y
P
E
RI
IQ
FG
E
G
N
F
L
RA
FVDW
Q
I
D
L
L
N
E
H
TD
L
NS
G
VVV
V
R
P
IE
T
S
-
--
F
PPS
L
ST
Q
DG
LYT
T
I
IRGLN
EKG
E
AV
SDA
R
L
I
R
SV
N
REI
S
V
Y
S
E
Y
D
E---
F
L
KLAHN
P
E
M
RF
V
FSN
T
TE
A
G
IS
Y
H
-
A
G
D
K
F
D
-
D
A
P
A
V
S
Y
--
-
--
--
P
A
KL
T
R
L
L
F
E
RF
SH
FNG
A
LD
K
G
WII
I
P
C
EL
I
DY
NG
DA
L
R
E
L
VL
R
Y
AQ
E
W
A
L
PE
AFI
Q
W
L
D
Q
A
N
SF
C
S
T
L
VDRIV
TGYP
R
D
E
V
A
KL
E
E
E
LG
Y
HD
GFLD
T
A
E
H
F
Y
LF
VI
QGPKSLATELRL
D
KY
-
-
---
-
-
-PL
N
V
L
I
V
D
D
I
K
PY
K
E
R
K
VAI
LNG
A
H
TA
L
VPVAFQ
A
G
LD
T
V
G
E
A
M
N
D
AEI
C
A
FV
EK
AI
Y
EE
II
P
V
L
D
LP
R
-
D
E
L
ES
F
A
SA
VT
G
RF
R
NP
Y
I
KHQ
LLS
IA
LN
G
MT
K
FRTRI
LPQ
-
LLAG
Q
K
-
--
A
K
GT
L
P
AR
L
TFAL
A
ALIAF
YR
G
-
E
RN
G
ETYP
V
Q
D
D
A
HW
L
E
R
Y
QQL
W
S
Q
HR
DRVIG
TQ
E
L
V
A
IV
L
A
E
KDH
W
E
Q
DL
T
Q
V
P
G
L
V
E
Q
V
AN
D
L
DA
I
L
E
K
G
M
REAVR
P
LC
fig|331111.12.peg.2005
Escherichia coli E24377A
MKTLNRRDFPGAQ
Y
P
E
RI
IQ
FG
E
G
N
F
L
RA
FVDW
Q
I
D
L
L
N
E
H
TD
L
NS
G
VVV
V
R
P
IE
T
S
-
--
F
PPS
L
ST
Q
DG
LYT
T
I
IRGLN
EKG
E
AV
SDA
R
L
I
R
SV
N
REI
S
V
Y
S
E
Y
D
E---
F
L
KLAHN
P
E
M
RF
V
FSN
T
TE
A
G
IS
Y
H
-
A
G
D
K
F
D
-
D
A
P
A
V
S
Y
--
-
--
--
P
A
KL
T
R
L
L
F
E
RF
SH
FNG
A
LD
K
G
WII
I
P
C
EL
I
DY
NG
DA
L
R
E
L
VL
R
Y
AQ
E
W
A
L
PE
AFI
Q
W
L
D
Q
A
N
SF
C
S
T
L
VDRIV
TGYP
R
D
E
V
A
KL
E
E
E
LG
Y
HD
GFLD
T
A
E
H
F
Y
LF
VI
QGPKSLATELRL
D
KY
-
-
---
-
-
-PL
N
V
L
I
V
D
D
I
K
PY
K
E
R
K
VAI
LNG
A
H
TA
L
VPVAFQ
A
G
LD
T
V
G
E
A
M
N
D
AEI
C
A
FV
EK
AI
Y
EE
II
P
V
L
D
LP
R
-
D
E
L
ES
F
A
SA
VT
G
RF
R
NP
Y
I
KHQ
LLS
IA
LN
G
MT
K
FRTRI
LPQ
-
LLAG
Q
K
-
--
A
K
GT
L
P
AR
L
TFAL
A
ALIAF
YR
G
-
E
RN
G
ETYP
V
Q
D
D
A
HW
L
E
R
Y
QQL
W
S
Q
HR
DRVIG
TQ
E
L
V
A
IV
L
A
E
KDH
W
E
Q
DL
T
Q
V
P
G
L
V
E
Q
V
AN
D
L
DA
I
L
E
K
G
M
REAVR
P
LC
fig|331111.3.peg.4163
Escherichia coli E24377A
MKTLNRRDFPGAQ
Y
P
E
RI
IQ
FG
E
G
N
F
L
RA
FVDW
Q
I
D
L
L
N
E
H
TD
L
NS
G
VVV
V
R
P
IE
T
S
-
--
F
PPS
L
ST
Q
DG
LYT
T
I
IRGLN
EKG
E
AV
SDA
R
L
I
R
SV
N
REI
S
V
Y
S
E
Y
D
E---
F
L
KLAHN
P
E
M
RF
V
FSN
T
TE
A
G
IS
Y
H
-
A
G
D
K
F
D
-
D
A
P
A
V
S
Y
--
-
--
--
P
A
KL
T
R
L
L
F
E
RF
SH
FNG
A
LD
K
G
WII
I
P
C
EL
I
DY
NG
DA
L
R
E
L
VL
R
Y
AQ
E
W
A
L
PE
AFI
Q
W
L
D
Q
A
N
SF
C
S
T
L
VDRIV
TGYP
R
D
E
V
A
KL
E
E
E
LG
Y
HD
GFLD
T
A
E
H
F
Y
LF
VI
QGPKSLATELRL
D
KY
-
-
---
-
-
-PL
N
V
L
I
V
D
D
I
K
PY
K
E
R
K
VAI
LNG
A
H
TA
L
VPVAFQ
A
G
LD
T
V
G
E
A
M
N
D
AEI
C
A
FV
EK
AI
Y
EE
II
P
V
L
D
LP
R
-
D
E
L
ES
F
A
SA
VT
G
RF
R
NP
Y
I
KHQ
LLS
IA
LN
G
MT
K
FRTRI
LPQ
-
LLAG
Q
K
-
--
A
K
GT
L
P
AR
L
TFAL
A
ALIAF
YR
G
-
E
RN
G
ETYP
V
Q
D
D
A
HW
L
E
R
Y
QQL
W
S
Q
HR
DRVIG
TQ
E
L
V
A
IV
L
A
E
KDH
W
E
Q
DL
T
Q
V
P
G
L
V
E
Q
V
AN
D
L
DA
I
L
E
K
G
M
REAVR
P
LC
fig|656408.3.peg.1685
Escherichia coli H591
MKTLNRRDFPGAQ
Y
P
E
RI
IQ
FG
E
G
N
F
L
RA
FVDW
Q
I
D
L
L
N
E
H
TD
L
NS
G
VVV
V
R
P
IE
T
S
-
--
F
PPS
L
ST
Q
DG
LYT
T
I
IRGLN
EKG
E
AV
SDA
R
L
I
R
SV
N
REI
S
V
Y
S
E
Y
D
E---
F
L
KLAHN
P
E
M
RF
V
FSN
T
TE
A
G
IS
Y
H
-
A
G
D
K
F
D
-
D
A
P
A
V
S
Y
--
-
--
--
P
A
KL
T
R
L
L
F
E
RF
SH
FNG
A
LD
K
G
WII
I
P
C
EL
I
DY
NG
DA
L
R
E
L
VL
R
Y
AQ
E
W
A
L
PE
AFI
Q
W
L
D
Q
A
N
SF
C
S
T
L
VDRIV
TGYP
R
D
E
V
A
KL
E
E
E
LG
Y
HD
GFLD
T
A
E
H
F
Y
LF
VI
QGPKSLATELRL
D
KY
-
-
---
-
-
-PL
N
V
L
I
V
D
D
I
K
PY
K
E
R
K
VAI
LNG
A
H
TA
L
VPVAFQ
A
G
LD
T
V
G
E
A
M
N
D
AEI
C
A
FV
EK
AI
Y
EE
II
P
V
L
D
LP
R
-
D
E
L
ES
F
A
SA
VT
G
RF
R
NP
Y
I
KHQ
LLS
IA
LN
G
MT
K
FRTRI
LPQ
-
LLAG
Q
K
-
--
A
K
GT
L
P
AR
L
TFAL
A
ALIAF
YR
G
-
E
RN
G
ETYP
V
Q
D
D
A
HW
L
E
R
Y
QQL
W
S
Q
HR
DRVIG
TQ
E
L
V
A
IV
L
A
E
KDH
W
E
Q
DL
T
Q
V
P
G
L
V
E
Q
V
AN
D
L
DA
I
L
E
K
G
M
REAVR
P
LC
fig|331112.3.peg.1509
Escherichia coli HS
MKTLNRRDFPGAQ
Y
P
E
RI
IQ
FG
E
G
N
F
L
RA
FVDW
Q
I
D
L
L
N
E
H
TD
L
NS
G
VVV
V
R
P
IE
T
S
-
--
F
PPS
L
ST
Q
DG
LYT
T
I
IRGLN
EKG
E
AV
SDA
R
L
I
R
SV
N
REI
S
V
Y
S
E
Y
D
E---
F
L
KLAHN
P
E
M
RF
V
FSN
T
TE
A
G
IS
Y
H
-
A
G
D
K
F
D
-
D
A
P
A
V
S
Y
--
-
--
--
P
A
KL
T
R
L
L
F
E
RF
SH
FNG
A
LD
K
G
WII
I
P
C
EL
I
DY
NG
DA
L
R
E
L
VL
R
Y
AQ
E
W
A
L
PE
AFI
Q
W
L
D
Q
A
N
SF
C
S
T
L
VDRIV
TGYP
R
D
E
V
A
KL
E
E
E
LG
Y
HD
GFLD
T
A
E
H
F
Y
LF
VI
QGPKSLATELRL
D
KY
-
-
---
-
-
-PL
N
V
L
I
V
D
D
I
K
PY
K
E
R
K
VAI
LNG
A
H
TA
L
VPVAFQ
A
G
LD
T
V
G
E
A
M
N
D
AEI
C
A
FV
EK
AI
Y
EE
II
P
V
L
D
LP
R
-
D
E
L
ES
F
A
SA
VT
G
RF
R
NP
Y
I
KHQ
LLS
IA
LN
G
MT
K
FRTRI
LPQ
-
LLAG
Q
K
-
--
A
K
GT
L
P
AR
L
TFAL
A
ALIAF
YR
G
-
E
RN
G
ETYP
V
Q
D
D
A
HW
L
E
R
Y
QQL
W
S
Q
HR
DRVIG
TQ
E
L
V
A
IV
L
A
E
KDH
W
E
Q
DL
T
Q
V
P
G
L
V
E
Q
V
AN
D
L
DA
I
L
E
K
G
M
REAVR
P
LC
fig|331112.6.peg.1566
Escherichia coli HS
MKTLNRRDFPGAQ
Y
P
E
RI
IQ
FG
E
G
N
F
L
RA
FVDW
Q
I
D
L
L
N
E
H
TD
L
NS
G
VVV
V
R
P
IE
T
S
-
--
F
PPS
L
ST
Q
DG
LYT
T
I
IRGLN
EKG
E
AV
SDA
R
L
I
R
SV
N
REI
S
V
Y
S
E
Y
D
E---
F
L
KLAHN
P
E
M
RF
V
FSN
T
TE
A
G
IS
Y
H
-
A
G
D
K
F
D
-
D
A
P
A
V
S
Y
--
-
--
--
P
A
KL
T
R
L
L
F
E
RF
SH
FNG
A
LD
K
G
WII
I
P
C
EL
I
DY
NG
DA
L
R
E
L
VL
R
Y
AQ
E
W
A
L
PE
AFI
Q
W
L
D
Q
A
N
SF
C
S
T
L
VDRIV
TGYP
R
D
E
V
A
KL
E
E
E
LG
Y
HD
GFLD
T
A
E
H
F
Y
LF
VI
QGPKSLATELRL
D
KY
-
-
---
-
-
-PL
N
V
L
I
V
D
D
I
K
PY
K
E
R
K
VAI
LNG
A
H
TA
L
VPVAFQ
A
G
LD
T
V
G
E
A
M
N
D
AEI
C
A
FV
EK
AI
Y
EE
II
P
V
L
D
LP
R
-
D
E
L
ES
F
A
SA
VT
G
RF
R
NP
Y
I
KHQ
LLS
IA
LN
G
MT
K
FRTRI
LPQ
-
LLAG
Q
K
-
--
A
K
GT
L
P
AR
L
TFAL
A
ALIAF
YR
G
-
E
RN
G
ETYP
V
Q
D
D
A
HW
L
E
R
Y
QQL
W
S
Q
HR
DRVIG
TQ
E
L
V
A
IV
L
A
E
KDH
W
E
Q
DL
T
Q
V
P
G
L
V
E
Q
V
AN
D
L
DA
I
L
E
K
G
M
REAVR
P
LC
fig|585034.4.peg.1515
Escherichia coli IAI1
MKTLNRRDFPGAQ
Y
P
E
RI
IQ
FG
E
G
N
F
L
RA
FVDW
Q
I
D
L
L
N
E
H
TD
L
NS
G
VVV
V
R
P
IE
T
S
-
--
F
PPS
L
ST
Q
DG
LYT
T
I
IRGLN
EKG
E
AV
SDA
R
L
I
R
SV
N
REI
S
V
Y
S
E
Y
D
E---
F
L
KLAHN
P
E
M
RF
V
FSN
T
TE
A
G
IS
Y
H
-
A
G
D
K
F
D
-
D
A
P
A
V
S
Y
--
-
--
--
P
A
KL
T
R
L
L
F
E
RF
SH
FNG
A
LD
K
G
WII
I
P
C
EL
I
DY
NG
DA
L
R
E
L
VL
R
Y
AQ
E
W
A
L
PE
AFI
Q
W
L
D
Q
A
N
SF
C
S
T
L
VDRIV
TGYP
R
D
E
V
A
KL
E
E
E
LG
Y
HD
GFLD
T
A
E
H
F
Y
LF
VI
QGPKSLATELRL
D
KY
-
-
---
-
-
-PL
N
V
L
I
V
D
D
I
K
PY
K
E
R
K
VAI
LNG
A
H
TA
L
VPVAFQ
A
G
LD
T
V
G
E
A
M
N
D
AEI
C
A
FV
EK
AI
Y
EE
II
P
V
L
D
LP
R
-
D
E
L
ES
F
A
SA
VT
G
RF
R
NP
Y
I
KHQ
LLS
IA
LN
G
MT
K
FRTRI
LPQ
-
LLAG
Q
K
-
--
A
K
GT
L
P
AR
L
TFAL
A
ALIAF
YR
G
-
E
RN
G
ETYP
V
Q
D
D
A
HW
L
E
R
Y
QQL
W
S
Q
HR
DRVIG
TQ
E
L
V
A
IV
L
A
E
KDH
W
E
Q
DL
T
Q
V
P
G
L
V
E
Q
V
AN
D
L
DA
I
L
E
K
G
M
REAVR
P
LC
fig|585034.5.peg.1512
Escherichia coli IAI1
MKTLNRRDFPGAQ
Y
P
E
RI
IQ
FG
E
G
N
F
L
RA
FVDW
Q
I
D
L
L
N
E
H
TD
L
NS
G
VVV
V
R
P
IE
T
S
-
--
F
PPS
L
ST
Q
DG
LYT
T
I
IRGLN
EKG
E
AV
SDA
R
L
I
R
SV
N
REI
S
V
Y
S
E
Y
D
E---
F
L
KLAHN
P
E
M
RF
V
FSN
T
TE
A
G
IS
Y
H
-
A
G
D
K
F
D
-
D
A
P
A
V
S
Y
--
-
--
--
P
A
KL
T
R
L
L
F
E
RF
SH
FNG
A
LD
K
G
WII
I
P
C
EL
I
DY
NG
DA
L
R
E
L
VL
R
Y
AQ
E
W
A
L
PE
AFI
Q
W
L
D
Q
A
N
SF
C
S
T
L
VDRIV
TGYP
R
D
E
V
A
KL
E
E
E
LG
Y
HD
GFLD
T
A
E
H
F
Y
LF
VI
QGPKSLATELRL
D
KY
-
-
---
-
-
-PL
N
V
L
I
V
D
D
I
K
PY
K
E
R
K
VAI
LNG
A
H
TA
L
VPVAFQ
A
G
LD
T
V
G
E
A
M
N
D
AEI
C
A
FV
EK
AI
Y
EE
II
P
V
L
D
LP
R
-
D
E
L
ES
F
A
SA
VT
G
RF
R
NP
Y
I
KHQ
LLS
IA
LN
G
MT
K
FRTRI
LPQ
-
LLAG
Q
K
-
--
A
K
GT
L
P
AR
L
TFAL
A
ALIAF
YR
G
-
E
RN
G
ETYP
V
Q
D
D
A
HW
L
E
R
Y
QQL
W
S
Q
HR
DRVIG
TQ
E
L
V
A
IV
L
A
E
KDH
W
E
Q
DL
T
Q
V
P
G
L
V
E
Q
V
AN
D
L
DA
I
L
E
K
G
M
REAVR
P
LC
fig|595495.4.peg.3452
Escherichia coli KO11
MKTLNRRDFPGAQ
Y
P
E
RI
IQ
FG
E
G
N
F
L
RA
FVDW
Q
I
D
L
L
N
E
H
TD
L
NS
G
VVV
V
R
P
IE
T
S
-
--
F
PPS
L
ST
Q
DG
LYT
T
I
IRGLN
EKG
E
AV
SDA
R
L
I
R
SV
N
REI
S
V
Y
S
E
Y
D
E---
F
L
KLAHN
P
E
M
RF
V
FSN
T
TE
A
G
IS
Y
H
-
A
G
D
K
F
D
-
D
A
P
A
V
S
Y
--
-
--
--
P
A
KL
T
R
L
L
F
E
RF
SH
FNG
A
LD
K
G
WII
I
P
C
EL
I
DY
NG
DA
L
R
E
L
VL
R
Y
AQ
E
W
A
L
PE
AFI
Q
W
L
D
Q
A
N
SF
C
S
T
L
VDRIV
TGYP
R
D
E
V
A
KL
E
E
E
LG
Y
HD
GFLD
T
A
E
H
F
Y
LF
VI
QGPKSLATELRL
D
KY
-
-
---
-
-
-PL
N
V
L
I
V
D
D
I
K
PY
K
E
R
K
VAI
LNG
A
H
TA
L
VPVAFQ
A
G
LD
T
V
G
E
A
M
N
D
AEI
C
A
FV
EK
AI
Y
EE
II
P
V
L
D
LP
R
-
D
E
L
ES
F
A
SA
VT
G
RF
R
NP
Y
I
KHQ
LLS
IA
LN
G
MT
K
FRTRI
LPQ
-
LLAG
Q
K
-
--
A
K
GT
L
P
AR
L
TFAL
A
ALIAF
YR
G
-
E
RN
G
ETYP
V
Q
D
D
A
HW
L
E
R
Y
QQL
W
S
Q
HR
DRVIG
TQ
E
L
V
A
IV
L
A
E
KDH
W
E
Q
DL
T
Q
V
P
G
L
V
E
Q
V
AN
D
L
DA
I
L
E
K
G
M
REAVR
P
LC
fig|679206.4.peg.3279
Escherichia coli MS 119-7
MKTLNRRDFPGAQ
Y
P
E
RI
IQ
FG
E
G
N
F
L
RA
FVDW
Q
I
D
L
L
N
E
H
TD
L
NS
G
VVV
V
R
P
IE
T
S
-
--
F
PPS
L
ST
Q
DG
LYT
T
I
IRGLN
EKG
E
AV
SDA
R
L
I
R
SV
N
REI
S
V
Y
S
E
Y
D
E---
F
L
KLAHN
P
E
M
RF
V
FSN
T
TE
A
G
IS
Y
H
-
A
G
D
K
F
D
-
D
A
P
A
V
S
Y
--
-
--
--
P
A
KL
T
R
L
L
F
E
RF
SH
FNG
A
LD
K
G
WII
I
P
C
EL
I
DY
NG
DA
L
R
E
L
VL
R
Y
AQ
E
W
A
L
PE
AFI
Q
W
L
D
Q
A
N
SF
C
S
T
L
VDRIV
TGYP
R
D
E
V
A
KL
E
E
E
LG
Y
HD
GFLD
T
A
E
H
F
Y
LF
VI
QGPKSLATELRL
D
KY
-
-
---
-
-
-PL
N
V
L
I
V
D
D
I
K
PY
K
E
R
K
VAI
LNG
A
H
TA
L
VPVAFQ
A
G
LD
T
V
G
E
A
M
N
D
AEI
C
A
FV
EK
AI
Y
EE
II
P
V
L
D
LP
R
-
D
E
L
ES
F
A
SA
VT
G
RF
R
NP
Y
I
KHQ
LLS
IA
LN
G
MT
K
FRTRI
LPQ
-
LLAG
Q
K
-
--
A
K
GT
L
P
AR
L
TFAL
A
ALIAF
YR
G
-
E
RN
G
ETYP
V
Q
D
D
A
HW
L
E
R
Y
QQL
W
S
Q
HR
DRVIG
TQ
E
L
V
A
IV
L
A
E
KDH
W
E
Q
DL
T
Q
V
P
G
L
V
E
Q
V
AN
D
L
DA
I
L
E
K
G
M
REAVR
P
LC
fig|679205.4.peg.5150
Escherichia coli MS 124-1
MKTLNRRDFPGAQ
Y
P
E
RI
IQ
FG
E
G
N
F
L
RA
FVDW
Q
I
D
L
L
N
E
H
TD
L
NS
G
VVV
V
R
P
IE
T
S
-
--
F
PPS
L
ST
Q
DG
LYT
T
I
IRGLN
EKG
E
AV
SDA
R
L
I
R
SV
N
REI
S
V
Y
S
E
Y
D
E---
F
L
KLAHN
P
E
M
RF
V
FSN
T
TE
A
G
IS
Y
H
-
A
G
D
K
F
D
-
D
A
P
A
V
S
Y
--
-
--
--
P
A
KL
T
R
L
L
F
E
RF
SH
FNG
A
LD
K
G
WII
I
P
C
EL
I
DY
NG
DA
L
R
E
L
VL
R
Y
AQ
E
W
A
L
PE
AFI
Q
W
L
D
Q
A
N
SF
C
S
T
L
VDRIV
TGYP
R
D
E
V
A
KL
E
E
E
LG
Y
HD
GFLD
T
A
E
H
F
Y
LF
VI
QGPKSLATELRL
D
KY
-
-
---
-
-
-PL
N
V
L
I
V
D
D
I
K
PY
K
E
R
K
VAI
LNG
A
H
TA
L
VPVAFQ
A
G
LD
T
V
G
E
A
M
N
D
AEI
C
A
FV
EK
AI
Y
EE
II
P
V
L
D
LP
R
-
D
E
L
ES
F
A
SA
VT
G
RF
R
NP
Y
I
KHQ
LLS
IA
LN
G
MT
K
FRTRI
LPQ
-
LLAG
Q
K
-
--
A
K
GT
L
P
AR
L
TFAL
A
ALIAF
YR
G
-
E
RN
G
ETYP
V
Q
D
D
A
HW
L
E
R
Y
QQL
W
S
Q
HR
DRVIG
TQ
E
L
V
A
IV
L
A
E
KDH
W
E
Q
DL
T
Q
V
P
G
L
V
E
Q
V
AN
D
L
DA
I
L
E
K
G
M
REAVR
P
LC
fig|679204.3.peg.3848
Escherichia coli MS 145-7
MKTLNRRDFPGAQ
Y
P
E
RI
IQ
FG
E
G
N
F
L
RA
FVDW
Q
I
D
L
L
N
E
H
TD
L
NS
G
VVV
V
R
P
IE
T
S
-
--
F
PPS
L
ST
Q
DG
LYT
T
I
IRGLN
EKG
E
AV
SDA
R
L
I
R
SV
N
REI
S
V
Y
S
E
Y
D
E---
F
L
KLAHN
P
E
M
RF
V
FSN
T
TE
A
G
IS
Y
H
-
A
G
D
K
F
D
-
D
A
P
A
V
S
Y
--
-
--
--
P
A
KL
T
R
L
L
F
E
RF
SH
FNG
A
LD
K
G
WII
I
P
C
EL
I
DY
NG
DA
L
R
E
L
VL
R
Y
AQ
E
W
A
L
PE
AFI
Q
W
L
D
Q
A
N
SF
C
S
T
L
VDRIV
TGYP
R
D
E
V
A
KL
E
E
E
LG
Y
HD
GFLD
T
A
E
H
F
Y
LF
VI
QGPKSLATELRL
D
KY
-
-
---
-
-
-PL
N
V
L
I
V
D
D
I
K
PY
K
E
R
K
VAI
LNG
A
H
TA
L
VPVAFQ
A
G
LD
T
V
G
E
A
M
N
D
AEI
C
A
FV
EK
AI
Y
EE
II
P
V
L
D
LP
R
-
D
E
L
ES
F
A
SA
VT
G
RF
R
NP
Y
I
KHQ
LLS
IA
LN
G
MT
K
FRTRI
LPQ
-
LLAG
Q
K
-
--
A
K
GT
L
P
AR
L
TFAL
A
ALIAF
YR
G
-
E
RN
G
ETYP
V
Q
D
D
A
HW
L
E
R
Y
QQL
W
S
Q
HR
DRVIG
TQ
E
L
V
A
IV
L
A
E
KDH
W
E
Q
DL
T
Q
V
P
G
L
V
E
Q
V
AN
D
L
DA
I
L
E
K
G
M
REAVR
P
LC
fig|749545.3.peg.5064
Escherichia coli MS 182-1
MKTLNRRDFPGAQ
Y
P
E
RI
IQ
FG
E
G
N
F
L
RA
FVDW
Q
I
D
L
L
N
E
H
TD
L
NS
G
VVV
V
R
P
IE
T
S
-
--
F
PPS
L
ST
Q
DG
LYT
T
I
IRGLN
EKG
E
AV
SDA
R
L
I
R
SV
N
REI
S
V
Y
S
E
Y
D
E---
F
L
KLAHN
P
E
M
RF
V
FSN
T
TE
A
G
IS
Y
H
-
A
G
D
K
F
D
-
D
A
P
A
V
S
Y
--
-
--
--
P
A
KL
T
R
L
L
F
E
RF
SH
FNG
A
LD
K
G
WII
I
P
C
EL
I
DY
NG
DA
L
R
E
L
VL
R
Y
AQ
E
W
A
L
PE
AFI
Q
W
L
D
Q
A
N
SF
C
S
T
L
VDRIV
TGYP
R
D
E
V
A
KL
E
E
E
LG
Y
HD
GFLD
T
A
E
H
F
Y
LF
VI
QGPKSLATELRL
D
KY
-
-
---
-
-
-PL
N
V
L
I
V
D
D
I
K
PY
K
E
R
K
VAI
LNG
A
H
TA
L
VPVAFQ
A
G
LD
T
V
G
E
A
M
N
D
AEI
C
A
FV
EK
AI
Y
EE
II
P
V
L
D
LP
R
-
D
E
L
ES
F
A
SA
VT
G
RF
R
NP
Y
I
KHQ
LLS
IA
LN
G
MT
K
FRTRI
LPQ
-
LLAG
Q
K
-
--
A
K
GT
L
P
AR
L
TFAL
A
ALIAF
YR
G
-
E
RN
G
ETYP
V
Q
D
D
A
HW
L
E
R
Y
QQL
W
S
Q
HR
DRVIG
TQ
E
L
V
A
IV
L
A
E
KDH
W
E
Q
DL
T
Q
V
P
G
L
V
E
Q
V
AN
D
L
DA
I
L
E
K
G
M
REAVR
P
LC
fig|749532.3.peg.1407
Escherichia coli MS 78-1
MKTLNRRDFPGAQ
Y
P
E
RI
IQ
FG
E
G
N
F
L
RA
FVDW
Q
I
D
L
L
N
E
H
TD
L
NS
G
VVV
V
R
P
IE
T
S
-
--
F
PPS
L
ST
Q
DG
LYT
T
I
IRGLN
EKG
E
AV
SDA
R
L
I
R
SV
N
REI
S
V
Y
S
E
Y
D
E---
F
L
KLAHN
P
E
M
RF
V
FSN
T
TE
A
G
IS
Y
H
-
A
G
D
K
F
D
-
D
A
P
A
V
S
Y
--
-
--
--
P
A
KL
T
R
L
L
F
E
RF
SH
FNG
A
LD
K
G
WII
I
P
C
EL
I
DY
NG
DA
L
R
E
L
VL
R
Y
AQ
E
W
A
L
PE
AFI
Q
W
L
D
Q
A
N
SF
C
S
T
L
VDRIV
TGYP
R
D
E
V
A
KL
E
E
E
LG
Y
HD
GFLD
T
A
E
H
F
Y
LF
VI
QGPKSLATELRL
D
KY
-
-
---
-
-
-PL
N
V
L
I
V
D
D
I
K
PY
K
E
R
K
VAI
LNG
A
H
TA
L
VPVAFQ
A
G
LD
T
V
G
E
A
M
N
D
AEI
C
A
FV
EK
AI
Y
EE
II
P
V
L
D
LP
R
-
D
E
L
ES
F
A
SA
VT
G
RF
R
NP
Y
I
KHQ
LLS
IA
LN
G
MT
K
FRTRI
LPQ
-
LLAG
Q
K
-
--
A
K
GT
L
P
AR
L
TFAL
A
ALIAF
YR
G
-
E
RN
G
ETYP
V
Q
D
D
A
HW
L
E
R
Y
QQL
W
S
Q
HR
DRVIG
TQ
E
L
V
A
IV
L
A
E
KDH
W
E
Q
DL
T
Q
V
P
G
L
V
E
Q
V
AN
D
L
DA
I
L
E
K
G
M
REAVR
P
LC
fig|749533.3.peg.1854
Escherichia coli MS 84-1
MKTLNRRDFPGAQ
Y
P
E
RI
IQ
FG
E
G
N
F
L
RA
FVDW
Q
I
D
L
L
N
E
H
TD
L
NS
G
VVV
V
R
P
IE
T
S
-
--
F
PPS
L
ST
Q
DG
LYT
T
I
IRGLN
EKG
E
AV
SDA
R
L
I
R
SV
N
REI
S
V
Y
S
E
Y
D
E---
F
L
KLAHN
P
E
M
RF
V
FSN
T
TE
A
G
IS
Y
H
-
A
G
D
K
F
D
-
D
A
P
A
V
S
Y
--
-
--
--
P
A
KL
T
R
L
L
F
E
RF
SH
FNG
A
LD
K
G
WII
I
P
C
EL
I
DY
NG
DA
L
R
E
L
VL
R
Y
AQ
E
W
A
L
PE
AFI
Q
W
L
D
Q
A
N
SF
C
S
T
L
VDRIV
TGYP
R
D
E
V
A
KL
E
E
E
LG
Y
HD
GFLD
T
A
E
H
F
Y
LF
VI
QGPKSLATELRL
D
KY
-
-
---
-
-
-PL
N
V
L
I
V
D
D
I
K
PY
K
E
R
K
VAI
LNG
A
H
TA
L
VPVAFQ
A
G
LD
T
V
G
E
A
M
N
D
AEI
C
A
FV
EK
AI
Y
EE
II
P
V
L
D
LP
R
-
D
E
L
ES
F
A
SA
VT
G
RF
R
NP
Y
I
KHQ
LLS
IA
LN
G
MT
K
FRTRI
LPQ
-
LLAG
Q
K
-
--
A
K
GT
L
P
AR
L
TFAL
A
ALIAF
YR
G
-
E
RN
G
ETYP
V
Q
D
D
A
HW
L
E
R
Y
QQL
W
S
Q
HR
DRVIG
TQ
E
L
V
A
IV
L
A
E
KDH
W
E
Q
DL
T
Q
V
P
G
L
V
E
Q
V
AN
D
L
DA
I
L
E
K
G
M
REAVR
P
LC
fig|409438.11.peg.1751
Escherichia coli SE11
MKTLNRRDFPGAQ
Y
P
E
RI
IQ
FG
E
G
N
F
L
RA
FVDW
Q
I
D
L
L
N
E
H
TD
L
NS
G
VVV
V
R
P
IE
T
S
-
--
F
PPS
L
ST
Q
DG
LYT
T
I
IRGLN
EKG
E
AV
SDA
R
L
I
R
SV
N
REI
S
V
Y
S
E
Y
D
E---
F
L
KLAHN
P
E
M
RF
V
FSN
T
TE
A
G
IS
Y
H
-
A
G
D
K
F
D
-
D
A
P
A
V
S
Y
--
-
--
--
P
A
KL
T
R
L
L
F
E
RF
SH
FNG
A
LD
K
G
WII
I
P
C
EL
I
DY
NG
DA
L
R
E
L
VL
R
Y
AQ
E
W
A
L
PE
AFI
Q
W
L
D
Q
A
N
SF
C
S
T
L
VDRIV
TGYP
R
D
E
V
A
KL
E
E
E
LG
Y
HD
GFLD
T
A
E
H
F
Y
LF
VI
QGPKSLATELRL
D
KY
-
-
---
-
-
-PL
N
V
L
I
V
D
D
I
K
PY
K
E
R
K
VAI
LNG
A
H
TA
L
VPVAFQ
A
G
LD
T
V
G
E
A
M
N
D
AEI
C
A
FV
EK
AI
Y
EE
II
P
V
L
D
LP
R
-
D
E
L
ES
F
A
SA
VT
G
RF
R
NP
Y
I
KHQ
LLS
IA
LN
G
MT
K
FRTRI
LPQ
-
LLAG
Q
K
-
--
A
K
GT
L
P
AR
L
TFAL
A
ALIAF
YR
G
-
E
RN
G
ETYP
V
Q
D
D
A
HW
L
E
R
Y
QQL
W
S
Q
HR
DRVIG
TQ
E
L
V
A
IV
L
A
E
KDH
W
E
Q
DL
T
Q
V
P
G
L
V
E
Q
V
AN
D
L
DA
I
L
E
K
G
M
REAVR
P
LC
fig|656443.3.peg.1874
Escherichia coli TA271
MKTLNRRDFPGAQ
Y
P
E
RI
IQ
FG
E
G
N
F
L
RA
FVDW
Q
I
D
L
L
N
E
H
TD
L
NS
G
VVV
V
R
P
IE
T
S
-
--
F
PPS
L
ST
Q
DG
LYT
T
I
IRGLN
EKG
E
AV
SDA
R
L
I
R
SV
N
REI
S
V
Y
S
E
Y
D
E---
F
L
KLAHN
P
E
M
RF
V
FSN
T
TE
A
G
IS
Y
H
-
A
G
D
K
F
D
-
D
A
P
A
V
S
Y
--
-
--
--
P
A
KL
T
R
L
L
F
E
RF
SH
FNG
A
LD
K
G
WII
I
P
C
EL
I
DY
NG
DA
L
R
E
L
VL
R
Y
AQ
E
W
A
L
PE
AFI
Q
W
L
D
Q
A
N
SF
C
S
T
L
VDRIV
TGYP
R
D
E
V
A
KL
E
E
E
LG
Y
HD
GFLD
T
A
E
H
F
Y
LF
VI
QGPKSLATELRL
D
KY
-
-
---
-
-
-PL
N
V
L
I
V
D
D
I
K
PY
K
E
R
K
VAI
LNG
A
H
TA
L
VPVAFQ
A
G
LD
T
V
G
E
A
M
N
D
AEI
C
A
FV
EK
AI
Y
EE
II
P
V
L
D
LP
R
-
D
E
L
ES
F
A
SA
VT
G
RF
R
NP
Y
I
KHQ
LLS
IA
LN
G
MT
K
FRTRI
LPQ
-
LLAG
Q
K
-
--
A
K
GT
L
P
AR
L
TFAL
A
ALIAF
YR
G
-
E
RN
G
ETYP
V
Q
D
D
A
HW
L
E
R
Y
QQL
W
S
Q
HR
DRVIG
TQ
E
L
V
A
IV
L
A
E
KDH
W
E
Q
DL
T
Q
V
P
G
L
V
E
Q
V
AN
D
L
DA
I
L
E
K
G
M
REAVR
P
LC
fig|566546.3.peg.1175
Escherichia coli W
MKTLNRRDFPGAQ
Y
P
E
RI
IQ
FG
E
G
N
F
L
RA
FVDW
Q
I
D
L
L
N
E
H
TD
L
NS
G
VVV
V
R
P
IE
T
S
-
--
F
PPS
L
ST
Q
DG
LYT
T
I
IRGLN
EKG
E
AV
SDA
R
L
I
R
SV
N
REI
S
V
Y
S
E
Y
D
E---
F
L
KLAHN
P
E
M
RF
V
FSN
T
TE
A
G
IS
Y
H
-
A
G
D
K
F
D
-
D
A
P
A
V
S
Y
--
-
--
--
P
A
KL
T
R
L
L
F
E
RF
SH
FNG
A
LD
K
G
WII
I
P
C
EL
I
DY
NG
DA
L
R
E
L
VL
R
Y
AQ
E
W
A
L
PE
AFI
Q
W
L
D
Q
A
N
SF
C
S
T
L
VDRIV
TGYP
R
D
E
V
A
KL
E
E
E
LG
Y
HD
GFLD
T
A
E
H
F
Y
LF
VI
QGPKSLATELRL
D
KY
-
-
---
-
-
-PL
N
V
L
I
V
D
D
I
K
PY
K
E
R
K
VAI
LNG
A
H
TA
L
VPVAFQ
A
G
LD
T
V
G
E
A
M
N
D
AEI
C
A
FV
EK
AI
Y
EE
II
P
V
L
D
LP
R
-
D
E
L
ES
F
A
SA
VT
G
RF
R
NP
Y
I
KHQ
LLS
IA
LN
G
MT
K
FRTRI
LPQ
-
LLAG
Q
K
-
--
A
K
GT
L
P
AR
L
TFAL
A
ALIAF
YR
G
-
E
RN
G
ETYP
V
Q
D
D
A
HW
L
E
R
Y
QQL
W
S
Q
HR
DRVIG
TQ
E
L
V
A
IV
L
A
E
KDH
W
E
Q
DL
T
Q
V
P
G
L
V
E
Q
V
AN
D
L
DA
I
L
E
K
G
M
REAVR
P
LC
fig|566546.4.peg.1641
Escherichia coli W
MKTLNRRDFPGAQ
Y
P
E
RI
IQ
FG
E
G
N
F
L
RA
FVDW
Q
I
D
L
L
N
E
H
TD
L
NS
G
VVV
V
R
P
IE
T
S
-
--
F
PPS
L
ST
Q
DG
LYT
T
I
IRGLN
EKG
E
AV
SDA
R
L
I
R
SV
N
REI
S
V
Y
S
E
Y
D
E---
F
L
KLAHN
P
E
M
RF
V
FSN
T
TE
A
G
IS
Y
H
-
A
G
D
K
F
D
-
D
A
P
A
V
S
Y
--
-
--
--
P
A
KL
T
R
L
L
F
E
RF
SH
FNG
A
LD
K
G
WII
I
P
C
EL
I
DY
NG
DA
L
R
E
L
VL
R
Y
AQ
E
W
A
L
PE
AFI
Q
W
L
D
Q
A
N
SF
C
S
T
L
VDRIV
TGYP
R
D
E
V
A
KL
E
E
E
LG
Y
HD
GFLD
T
A
E
H
F
Y
LF
VI
QGPKSLATELRL
D
KY
-
-
---
-
-
-PL
N
V
L
I
V
D
D
I
K
PY
K
E
R
K
VAI
LNG
A
H
TA
L
VPVAFQ
A
G
LD
T
V
G
E
A
M
N
D
AEI
C
A
FV
EK
AI
Y
EE
II
P
V
L
D
LP
R
-
D
E
L
ES
F
A
SA
VT
G
RF
R
NP
Y
I
KHQ
LLS
IA
LN
G
MT
K
FRTRI
LPQ
-
LLAG
Q
K
-
--
A
K
GT
L
P
AR
L
TFAL
A
ALIAF
YR
G
-
E
RN
G
ETYP
V
Q
D
D
A
HW
L
E
R
Y
QQL
W
S
Q
HR
DRVIG
TQ
E
L
V
A
IV
L
A
E
KDH
W
E
Q
DL
T
Q
V
P
G
L
V
E
Q
V
AN
D
L
DA
I
L
E
K
G
M
REAVR
P
LC
fig|340184.3.peg.35
Escherichia coli B7A
MKTLNRRDFPGAQ
Y
P
E
RI
IQ
FG
E
G
N
F
L
RA
FVDW
Q
I
D
L
L
N
E
H
TD
L
NS
G
VVV
V
R
P
IE
T
S
-
--
F
PPS
L
ST
Q
DG
LYT
T
I
IRGLN
EKG
E
AV
SDA
R
L
I
R
SV
N
REI
S
V
Y
S
E
Y
D
E---
F
L
KLAHN
P
E
M
RF
V
FSN
T
TE
A
G
IS
Y
H
-
A
G
E
K
F
D
-
D
A
P
A
V
S
Y
--
-
--
--
P
A
KL
T
R
L
L
F
E
RF
SH
FNG
A
LD
K
G
WII
I
P
C
EL
I
DY
NG
DA
L
R
E
L
VL
R
Y
AQ
E
W
A
L
PE
AFI
Q
W
L
D
Q
A
N
SF
C
S
T
L
VDRIV
TGYP
R
D
E
V
A
KL
E
E
E
LG
Y
HD
GFLD
T
A
E
H
F
Y
LF
VI
QGPKSLATELRL
D
KY
-
-
---
-
-
-PL
N
V
L
I
V
D
D
I
K
PY
K
E
R
K
VAI
LNG
A
H
TA
L
VPVAFQ
A
G
LD
T
V
G
E
A
M
N
D
AEI
C
A
FV
EK
AI
Y
EE
II
P
V
L
D
LP
R
-
D
E
L
ES
F
A
SA
VT
G
RF
R
NP
Y
I
KHQ
LLS
IA
LN
G
MT
K
FRTRI
LPQ
-
LLAG
Q
K
-
--
A
K
GT
L
P
AR
L
TFAL
A
ALIAF
YR
G
-
E
RN
G
ETYP
V
Q
D
D
A
HW
L
E
R
Y
QQL
W
S
Q
HR
DRVIG
TQ
E
L
V
A
IV
L
A
E
KDH
W
E
Q
DL
T
Q
V
P
G
L
V
E
Q
V
AN
D
L
DA
I
L
E
K
G
M
REAVR
P
LC
fig|340184.6.peg.40
Escherichia coli B7A
MKTLNRRDFPGAQ
Y
P
E
RI
IQ
FG
E
G
N
F
L
RA
FVDW
Q
I
D
L
L
N
E
H
TD
L
NS
G
VVV
V
R
P
IE
T
S
-
--
F
PPS
L
ST
Q
DG
LYT
T
I
IRGLN
EKG
E
AV
SDA
R
L
I
R
SV
N
REI
S
V
Y
S
E
Y
D
E---
F
L
KLAHN
P
E
M
RF
V
FSN
T
TE
A
G
IS
Y
H
-
A
G
E
K
F
D
-
D
A
P
A
V
S
Y
--
-
--
--
P
A
KL
T
R
L
L
F
E
RF
SH
FNG
A
LD
K
G
WII
I
P
C
EL
I
DY
NG
DA
L
R
E
L
VL
R
Y
AQ
E
W
A
L
PE
AFI
Q
W
L
D
Q
A
N
SF
C
S
T
L
VDRIV
TGYP
R
D
E
V
A
KL
E
E
E
LG
Y
HD
GFLD
T
A
E
H
F
Y
LF
VI
QGPKSLATELRL
D
KY
-
-
---
-
-
-PL
N
V
L
I
V
D
D
I
K
PY
K
E
R
K
VAI
LNG
A
H
TA
L
VPVAFQ
A
G
LD
T
V
G
E
A
M
N
D
AEI
C
A
FV
EK
AI
Y
EE
II
P
V
L
D
LP
R
-
D
E
L
ES
F
A
SA
VT
G
RF
R
NP
Y
I
KHQ
LLS
IA
LN
G
MT
K
FRTRI
LPQ
-
LLAG
Q
K
-
--
A
K
GT
L
P
AR
L
TFAL
A
ALIAF
YR
G
-
E
RN
G
ETYP
V
Q
D
D
A
HW
L
E
R
Y
QQL
W
S
Q
HR
DRVIG
TQ
E
L
V
A
IV
L
A
E
KDH
W
E
Q
DL
T
Q
V
P
G
L
V
E
Q
V
AN
D
L
DA
I
L
E
K
G
M
REAVR
P
LC
fig|358709.5.peg.1037
Escherichia coli 101-1
MKTLNRRDFPGAQ
Y
P
E
RI
IQ
FG
E
G
N
F
L
RA
FVDW
Q
I
D
L
L
N
E
H
TD
L
NS
G
VVV
V
R
P
IE
T
S
-
--
F
PPS
L
ST
Q
DG
LYT
T
I
IRGLN
EKG
E
AV
SDA
R
L
I
R
SV
N
REI
S
V
Y
S
E
Y
D
E---
F
L
KLAHN
P
E
M
RF
V
FSN
T
TE
A
G
IS
Y
H
-
A
G
D
K
F
D
-
D
A
P
A
V
S
Y
--
-
--
--
P
A
KL
T
R
L
L
F
E
RF
SH
FNG
A
LD
K
G
WII
I
P
C
EL
I
DY
NG
DA
L
R
E
L
VL
R
Y
AQ
E
W
A
L
PE
AFI
Q
W
L
D
Q
A
N
SF
C
S
T
L
VDRIV
TGYP
R
D
E
V
A
KL
E
E
E
LG
Y
HD
GFLD
T
A
E
H
F
Y
LF
VI
QGPKSLATELRL
D
KY
-
-
---
-
-
-PL
N
V
L
I
V
D
D
I
K
PY
K
E
R
K
VAI
LNG
A
H
TA
L
VPVAFQ
A
G
LD
T
V
G
E
A
M
N
D
AEI
C
A
FV
EK
AI
Y
EE
II
P
V
L
D
LP
R
-
D
E
L
ES
F
A
SA
VT
G
RF
R
NP
Y
I
KHQ
LLS
IA
LN
G
MT
K
FRTRI
LPQ
-
LLAG
Q
K
-
--
A
NGT
L
P
AR
L
TFAL
A
ALIAF
YR
G
-
E
RN
G
ETYP
V
Q
D
D
A
HW
L
E
R
Y
QQL
W
S
Q
HR
DRVIG
TQ
E
L
V
A
IV
L
A
E
KDH
W
E
Q
DL
T
Q
V
P
G
L
V
E
Q
V
AN
D
L
DA
I
L
E
K
G
M
REAVR
P
LC
fig|562.371.peg.1679
Escherichia coli 1044A
MKTLNRRDFPGAQ
Y
P
E
RI
IQ
FG
E
G
N
F
L
RA
FVDW
Q
I
D
L
L
N
E
H
TD
L
NS
G
VVV
V
R
P
IE
T
S
-
--
F
PPS
L
ST
Q
DG
LYT
T
I
IRGLN
EKG
E
AV
SDA
R
L
I
R
SV
N
REI
S
V
Y
S
E
Y
D
E---
F
L
KLAHN
P
E
M
RF
V
FSN
T
TE
A
G
IS
Y
H
-
A
G
D
K
F
D
-
D
A
P
A
V
S
Y
--
-
--
--
P
A
KL
T
R
L
L
F
E
RF
SH
FNG
A
LD
K
G
WII
I
P
C
EL
I
DY
NG
DA
L
R
E
L
VL
R
Y
AQ
E
W
A
L
PE
AFI
Q
W
L
D
Q
A
N
SF
C
S
T
L
VDRIV
TGYP
R
D
E
V
A
KL
E
E
E
LG
Y
HD
GFLD
T
A
E
H
F
Y
LF
VI
QGPKSLATELRL
D
KY
-
-
---
-
-
-PL
N
V
L
I
V
D
D
I
K
PY
K
E
R
K
VAI
LNG
A
H
TA
L
VPVAFQ
A
G
LD
T
V
G
E
A
M
N
D
AEI
C
A
FV
EK
AI
Y
EE
II
P
V
L
D
LP
R
-
D
E
L
ES
F
A
SA
VT
G
RF
R
NP
Y
I
KHQ
LLS
IA
LN
G
MT
K
FRTRI
LPQ
-
LLAG
Q
K
-
--
A
NGT
L
P
AR
L
TFAL
A
ALIAF
YR
G
-
E
RN
G
ETYP
V
Q
D
D
A
HW
L
E
R
Y
QQL
W
S
Q
HR
DRVIG
TQ
E
L
V
A
IV
L
A
E
KDH
W
E
Q
DL
T
Q
V
P
G
L
V
E
Q
V
AN
D
L
DA
I
L
E
K
G
M
REAVR
P
LC
fig|562.373.peg.5025
Escherichia coli 1125A
MKTLNRRDFPGAQ
Y
P
E
RI
IQ
FG
E
G
N
F
L
RA
FVDW
Q
I
D
L
L
N
E
H
TD
L
NS
G
VVV
V
R
P
IE
T
S
-
--
F
PPS
L
ST
Q
DG
LYT
T
I
IRGLN
EKG
E
AV
SDA
R
L
I
R
SV
N
REI
S
V
Y
S
E
Y
D
E---
F
L
KLAHN
P
E
M
RF
V
FSN
T
TE
A
G
IS
Y
H
-
A
G
D
K
F
D
-
D
A
P
A
V
S
Y
--
-
--
--
P
A
KL
T
R
L
L
F
E
RF
SH
FNG
A
LD
K
G
WII
I
P
C
EL
I
DY
NG
DA
L
R
E
L
VL
R
Y
AQ
E
W
A
L
PE
AFI
Q
W
L
D
Q
A
N
SF
C
S
T
L
VDRIV
TGYP
R
D
E
V
A
KL
E
E
E
LG
Y
HD
GFLD
T
A
E
H
F
Y
LF
VI
QGPKSLATELRL
D
KY
-
-
---
-
-
-PL
N
V
L
I
V
D
D
I
K
PY
K
E
R
K
VAI
LNG
A
H
TA
L
VPVAFQ
A
G
LD
T
V
G
E
A
M
N
D
AEI
C
A
FV
EK
AI
Y
EE
II
P
V
L
D
LP
R
-
D
E
L
ES
F
A
SA
VT
G
RF
R
NP
Y
I
KHQ
LLS
IA
LN
G
MT
K
FRTRI
LPQ
-
LLAG
Q
K
-
--
A
NGT
L
P
AR
L
TFAL
A
ALIAF
YR
G
-
E
RN
G
ETYP
V
Q
D
D
A
HW
L
E
R
Y
QQL
W
S
Q
HR
DRVIG
TQ
E
L
V
A
IV
L
A
E
KDH
W
E
Q
DL
T
Q
V
P
G
L
V
E
Q
V
AN
D
L
DA
I
L
E
K
G
M
REAVR
P
LC
fig|562.372.peg.1164
Escherichia coli 1212A
MKTLNRRDFPGAQ
Y
P
E
RI
IQ
FG
E
G
N
F
L
RA
FVDW
Q
I
D
L
L
N
E
H
TD
L
NS
G
VVV
V
R
P
IE
T
S
-
--
F
PPS
L
ST
Q
DG
LYT
T
I
IRGLN
EKG
E
AV
SDA
R
L
I
R
SV
N
REI
S
V
Y
S
E
Y
D
E---
F
L
KLAHN
P
E
M
RF
V
FSN
T
TE
A
G
IS
Y
H
-
A
G
D
K
F
D
-
D
A
P
A
V
S
Y
--
-
--
--
P
A
KL
T
R
L
L
F
E
RF
SH
FNG
A
LD
K
G
WII
I
P
C
EL
I
DY
NG
DA
L
R
E
L
VL
R
Y
AQ
E
W
A
L
PE
AFI
Q
W
L
D
Q
A
N
SF
C
S
T
L
VDRIV
TGYP
R
D
E
V
A
KL
E
E
E
LG
Y
HD
GFLD
T
A
E
H
F
Y
LF
VI
QGPKSLATELRL
D
KY
-
-
---
-
-
-PL
N
V
L
I
V
D
D
I
K
PY
K
E
R
K
VAI
LNG
A
H
TA
L
VPVAFQ
A
G
LD
T
V
G
E
A
M
N
D
AEI
C
A
FV
EK
AI
Y
EE
II
P
V
L
D
LP
R
-
D
E
L
ES
F
A
SA
VT
G
RF
R
NP
Y
I
KHQ
LLS
IA
LN
G
MT
K
FRTRI
LPQ
-
LLAG
Q
K
-
--
A
NGT
L
P
AR
L
TFAL
A
ALIAF
YR
G
-
E
RN
G
ETYP
V
Q
D
D
A
HW
L
E
R
Y
QQL
W
S
Q
HR
DRVIG
TQ
E
L
V
A
IV
L
A
E
KDH
W
E
Q
DL
T
Q
V
P
G
L
V
E
Q
V
AN
D
L
DA
I
L
E
K
G
M
REAVR
P
LC
fig|344610.3.peg.3509
Escherichia coli 53638
MKTLNRRDFPGAQ
Y
P
E
RI
IQ
FG
E
G
N
F
L
RA
FVDW
Q
I
D
L
L
N
E
H
TD
L
NS
G
VVV
V
R
P
IE
T
S
-
--
F
PPS
L
ST
Q
DG
LYT
T
I
IRGLN
EKG
E
AV
SDA
R
L
I
R
SV
N
REI
S
V
Y
S
E
Y
D
E---
F
L
KLAHN
P
E
M
RF
V
FSN
T
TE
A
G
IS
Y
H
-
A
G
D
K
F
D
-
D
A
P
A
V
S
Y
--
-
--
--
P
A
KL
T
R
L
L
F
E
RF
SH
FNG
A
LD
K
G
WII
I
P
C
EL
I
DY
NG
DA
L
R
E
L
VL
R
Y
AQ
E
W
A
L
PE
AFI
Q
W
L
D
Q
A
N
SF
C
S
T
L
VDRIV
TGYP
R
D
E
V
A
KL
E
E
E
LG
Y
HD
GFLD
T
A
E
H
F
Y
LF
VI
QGPKSLATELRL
D
KY
-
-
---
-
-
-PL
N
V
L
I
V
D
D
I
K
PY
K
E
R
K
VAI
LNG
A
H
TA
L
VPVAFQ
A
G
LD
T
V
G
E
A
M
N
D
AEI
C
A
FV
EK
AI
Y
EE
II
P
V
L
D
LP
R
-
D
E
L
ES
F
A
SA
VT
G
RF
R
NP
Y
I
KHQ
LLS
IA
LN
G
MT
K
FRTRI
LPQ
-
LLAG
Q
K
-
--
A
NGT
L
P
AR
L
TFAL
A
ALIAF
YR
G
-
E
RN
G
ETYP
V
Q
D
D
A
HW
L
E
R
Y
QQL
W
S
Q
HR
DRVIG
TQ
E
L
V
A
IV
L
A
E
KDH
W
E
Q
DL
T
Q
V
P
G
L
V
E
Q
V
AN
D
L
DA
I
L
E
K
G
M
REAVR
P
LC
fig|344610.7.peg.5201
Escherichia coli 53638
MKTLNRRDFPGAQ
Y
P
E
RI
IQ
FG
E
G
N
F
L
RA
FVDW
Q
I
D
L
L
N
E
H
TD
L
NS
G
VVV
V
R
P
IE
T
S
-
--
F
PPS
L
ST
Q
DG
LYT
T
I
IRGLN
EKG
E
AV
SDA
R
L
I
R
SV
N
REI
S
V
Y
S
E
Y
D
E---
F
L
KLAHN
P
E
M
RF
V
FSN
T
TE
A
G
IS
Y
H
-
A
G
D
K
F
D
-
D
A
P
A
V
S
Y
--
-
--
--
P
A
KL
T
R
L
L
F
E
RF
SH
FNG
A
LD
K
G
WII
I
P
C
EL
I
DY
NG
DA
L
R
E
L
VL
R
Y
AQ
E
W
A
L
PE
AFI
Q
W
L
D
Q
A
N
SF
C
S
T
L
VDRIV
TGYP
R
D
E
V
A
KL
E
E
E
LG
Y
HD
GFLD
T
A
E
H
F
Y
LF
VI
QGPKSLATELRL
D
KY
-
-
---
-
-
-PL
N
V
L
I
V
D
D
I
K
PY
K
E
R
K
VAI
LNG
A
H
TA
L
VPVAFQ
A
G
LD
T
V
G
E
A
M
N
D
AEI
C
A
FV
EK
AI
Y
EE
II
P
V
L
D
LP
R
-
D
E
L
ES
F
A
SA
VT
G
RF
R
NP
Y
I
KHQ
LLS
IA
LN
G
MT
K
FRTRI
LPQ
-
LLAG
Q
K
-
--
A
NGT
L
P
AR
L
TFAL
A
ALIAF
YR
G
-
E
RN
G
ETYP
V
Q
D
D
A
HW
L
E
R
Y
QQL
W
S
Q
HR
DRVIG
TQ
E
L
V
A
IV
L
A
E
KDH
W
E
Q
DL
T
Q
V
P
G
L
V
E
Q
V
AN
D
L
DA
I
L
E
K
G
M
REAVR
P
LC
fig|562.374.peg.2420
Escherichia coli 536A
MKTLNRRDFPGAQ
Y
P
E
RI
IQ
FG
E
G
N
F
L
RA
FVDW
Q
I
D
L
L
N
E
H
TD
L
NS
G
VVV
V
R
P
IE
T
S
-
--
F
PPS
L
ST
Q
DG
LYT
T
I
IRGLN
EKG
E
AV
SDA
R
L
I
R
SV
N
REI
S
V
Y
S
E
Y
D
E---
F
L
KLAHN
P
E
M
RF
V
FSN
T
TE
A
G
IS
Y
H
-
A
G
D
K
F
D
-
D
A
P
A
V
S
Y
--
-
--
--
P
A
KL
T
R
L
L
F
E
RF
SH
FNG
A
LD
K
G
WII
I
P
C
EL
I
DY
NG
DA
L
R
E
L
VL
R
Y
AQ
E
W
A
L
PE
AFI
Q
W
L
D
Q
A
N
SF
C
S
T
L
VDRIV
TGYP
R
D
E
V
A
KL
E
E
E
LG
Y
HD
GFLD
T
A
E
H
F
Y
LF
VI
QGPKSLATELRL
D
KY
-
-
---
-
-
-PL
N
V
L
I
V
D
D
I
K
PY
K
E
R
K
VAI
LNG
A
H
TA
L
VPVAFQ
A
G
LD
T
V
G
E
A
M
N
D
AEI
C
A
FV
EK
AI
Y
EE
II
P
V
L
D
LP
R
-
D
E
L
ES
F
A
SA
VT
G
RF
R
NP
Y
I
KHQ
LLS
IA
LN
G
MT
K
FRTRI
LPQ
-
LLAG
Q
K
-
--
A
NGT
L
P
AR
L
TFAL
A
ALIAF
YR
G
-
E
RN
G
ETYP
V
Q
D
D
A
HW
L
E
R
Y
QQL
W
S
Q
HR
DRVIG
TQ
E
L
V
A
IV
L
A
E
KDH
W
E
Q
DL
T
Q
V
P
G
L
V
E
Q
V
AN
D
L
DA
I
L
E
K
G
M
REAVR
P
LC
fig|413997.3.peg.1556
Escherichia coli B str. REL606
MKTLNRRDFPGAQ
Y
P
E
RI
IQ
FG
E
G
N
F
L
RA
FVDW
Q
I
D
L
L
N
E
H
TD
L
NS
G
VVV
V
R
P
IE
T
S
-
--
F
PPS
L
ST
Q
DG
LYT
T
I
IRGLN
EKG
E
AV
SDA
R
L
I
R
SV
N
REI
S
V
Y
S
E
Y
D
E---
F
L
KLAHN
P
E
M
RF
V
FSN
T
TE
A
G
IS
Y
H
-
A
G
D
K
F
D
-
D
A
P
A
V
S
Y
--
-
--
--
P
A
KL
T
R
L
L
F
E
RF
SH
FNG
A
LD
K
G
WII
I
P
C
EL
I
DY
NG
DA
L
R
E
L
VL
R
Y
AQ
E
W
A
L
PE
AFI
Q
W
L
D
Q
A
N
SF
C
S
T
L
VDRIV
TGYP
R
D
E
V
A
KL
E
E
E
LG
Y
HD
GFLD
T
A
E
H
F
Y
LF
VI
QGPKSLATELRL
D
KY
-
-
---
-
-
-PL
N
V
L
I
V
D
D
I
K
PY
K
E
R
K
VAI
LNG
A
H
TA
L
VPVAFQ
A
G
LD
T
V
G
E
A
M
N
D
AEI
C
A
FV
EK
AI
Y
EE
II
P
V
L
D
LP
R
-
D
E
L
ES
F
A
SA
VT
G
RF
R
NP
Y
I
KHQ
LLS
IA
LN
G
MT
K
FRTRI
LPQ
-
LLAG
Q
K
-
--
A
NGT
L
P
AR
L
TFAL
A
ALIAF
YR
G
-
E
RN
G
ETYP
V
Q
D
D
A
HW
L
E
R
Y
QQL
W
S
Q
HR
DRVIG
TQ
E
L
V
A
IV
L
A
E
KDH
W
E
Q
DL
T
Q
V
P
G
L
V
E
Q
V
AN
D
L
DA
I
L
E
K
G
M
REAVR
P
LC
fig|550672.3.peg.2388
Escherichia coli B088
MKTLNRRDFPGAQ
Y
P
E
RI
IQ
FG
E
G
N
F
L
RA
FVDW
Q
I
D
L
L
N
E
H
TD
L
NS
G
VVV
V
R
P
IE
T
S
-
--
F
PPS
L
ST
Q
DG
LYT
T
I
IRGLN
EKG
E
AV
SDA
R
L
I
R
SV
N
REI
S
V
Y
S
E
Y
D
E---
F
L
KLAHN
P
E
M
RF
V
FSN
T
TE
A
G
IS
Y
H
-
A
G
D
K
F
D
-
D
A
P
A
V
S
Y
--
-
--
--
P
A
KL
T
R
L
L
F
E
RF
SH
FNG
A
LD
K
G
WII
I
P
C
EL
I
DY
NG
DA
L
R
E
L
VL
R
Y
AQ
E
W
A
L
PE
AFI
Q
W
L
D
Q
A
N
SF
C
S
T
L
VDRIV
TGYP
R
D
E
V
A
KL
E
E
E
LG
Y
HD
GFLD
T
A
E
H
F
Y
LF
VI
QGPKSLATELRL
D
KY
-
-
---
-
-
-PL
N
V
L
I
V
D
D
I
K
PY
K
E
R
K
VAI
LNG
A
H
TA
L
VPVAFQ
A
G
LD
T
V
G
E
A
M
N
D
AEI
C
A
FV
EK
AI
Y
EE
II
P
V
L
D
LP
R
-
D
E
L
ES
F
A
SA
VT
G
RF
R
NP
Y
I
KHQ
LLS
IA
LN
G
MT
K
FRTRI
LPQ
-
LLAG
Q
K
-
--
A
NGT
L
P
AR
L
TFAL
A
ALIAF
YR
G
-
E
RN
G
ETYP
V
Q
D
D
A
HW
L
E
R
Y
QQL
W
S
Q
HR
DRVIG
TQ
E
L
V
A
IV
L
A
E
KDH
W
E
Q
DL
T
Q
V
P
G
L
V
E
Q
V
AN
D
L
DA
I
L
E
K
G
M
REAVR
P
LC
fig|550676.3.peg.1860
Escherichia coli B185
MKTLNRRDFPGAQ
Y
P
E
RI
IQ
FG
E
G
N
F
L
RA
FVDW
Q
I
D
L
L
N
E
H
TD
L
NS
G
VVV
V
R
P
IE
T
S
-
--
F
PPS
L
ST
Q
DG
LYT
T
I
IRGLN
EKG
E
AV
SDA
R
L
I
R
SV
N
REI
S
V
Y
S
E
Y
D
E---
F
L
KLAHN
P
E
M
RF
V
FSN
T
TE
A
G
IS
Y
H
-
A
G
D
K
F
D
-
D
A
P
A
V
S
Y
--
-
--
--
P
A
KL
T
R
L
L
F
E
RF
SH
FNG
A
LD
K
G
WII
I
P
C
EL
I
DY
NG
DA
L
R
E
L
VL
R
Y
AQ
E
W
A
L
PE
AFI
Q
W
L
D
Q
A
N
SF
C
S
T
L
VDRIV
TGYP
R
D
E
V
A
KL
E
E
E
LG
Y
HD
GFLD
T
A
E
H
F
Y
LF
VI
QGPKSLATELRL
D
KY
-
-
---
-
-
-PL
N
V
L
I
V
D
D
I
K
PY
K
E
R
K
VAI
LNG
A
H
TA
L
VPVAFQ
A
G
LD
T
V
G
E
A
M
N
D
AEI
C
A
FV
EK
AI
Y
EE
II
P
V
L
D
LP
R
-
D
E
L
ES
F
A
SA
VT
G
RF
R
NP
Y
I
KHQ
LLS
IA
LN
G
MT
K
FRTRI
LPQ
-
LLAG
Q
K
-
--
A
NGT
L
P
AR
L
TFAL
A
ALIAF
YR
G
-
E
RN
G
ETYP
V
Q
D
D
A
HW
L
E
R
Y
QQL
W
S
Q
HR
DRVIG
TQ
E
L
V
A
IV
L
A
E
KDH
W
E
Q
DL
T
Q
V
P
G
L
V
E
Q
V
AN
D
L
DA
I
L
E
K
G
M
REAVR
P
LC
fig|511693.5.peg.1595
Escherichia coli BL21
MKTLNRRDFPGAQ
Y
P
E
RI
IQ
FG
E
G
N
F
L
RA
FVDW
Q
I
D
L
L
N
E
H
TD
L
NS
G
VVV
V
R
P
IE
T
S
-
--
F
PPS
L
ST
Q
DG
LYT
T
I
IRGLN
EKG
E
AV
SDA
R
L
I
R
SV
N
REI
S
V
Y
S
E
Y
D
E---
F
L
KLAHN
P
E
M
RF
V
FSN
T
TE
A
G
IS
Y
H
-
A
G
D
K
F
D
-
D
A
P
A
V
S
Y
--
-
--
--
P
A
KL
T
R
L
L
F
E
RF
SH
FNG
A
LD
K
G
WII
I
P
C
EL
I
DY
NG
DA
L
R
E
L
VL
R
Y
AQ
E
W
A
L
PE
AFI
Q
W
L
D
Q
A
N
SF
C
S
T
L
VDRIV
TGYP
R
D
E
V
A
KL
E
E
E
LG
Y
HD
GFLD
T
A
E
H
F
Y
LF
VI
QGPKSLATELRL
D
KY
-
-
---
-
-
-PL
N
V
L
I
V
D
D
I
K
PY
K
E
R
K
VAI
LNG
A
H
TA
L
VPVAFQ
A
G
LD
T
V
G
E
A
M
N
D
AEI
C
A
FV
EK
AI
Y
EE
II
P
V
L
D
LP
R
-
D
E
L
ES
F
A
SA
VT
G
RF
R
NP
Y
I
KHQ
LLS
IA
LN
G
MT
K
FRTRI
LPQ
-
LLAG
Q
K
-
--
A
NGT
L
P
AR
L
TFAL
A
ALIAF
YR
G
-
E
RN
G
ETYP
V
Q
D
D
A
HW
L
E
R
Y
QQL
W
S
Q
HR
DRVIG
TQ
E
L
V
A
IV
L
A
E
KDH
W
E
Q
DL
T
Q
V
P
G
L
V
E
Q
V
AN
D
L
DA
I
L
E
K
G
M
REAVR
P
LC
fig|469008.4.peg.2179
Escherichia coli BL21(DE3)
MKTLNRRDFPGAQ
Y
P
E
RI
IQ
FG
E
G
N
F
L
RA
FVDW
Q
I
D
L
L
N
E
H
TD
L
NS
G
VVV
V
R
P
IE
T
S
-
--
F
PPS
L
ST
Q
DG
LYT
T
I
IRGLN
EKG
E
AV
SDA
R
L
I
R
SV
N
REI
S
V
Y
S
E
Y
D
E---
F
L
KLAHN
P
E
M
RF
V
FSN
T
TE
A
G
IS
Y
H
-
A
G
D
K
F
D
-
D
A
P
A
V
S
Y
--
-
--
--
P
A
KL
T
R
L
L
F
E
RF
SH
FNG
A
LD
K
G
WII
I
P
C
EL
I
DY
NG
DA
L
R
E
L
VL
R
Y
AQ
E
W
A
L
PE
AFI
Q
W
L
D
Q
A
N
SF
C
S
T
L
VDRIV
TGYP
R
D
E
V
A
KL
E
E
E
LG
Y
HD
GFLD
T
A
E
H
F
Y
LF
VI
QGPKSLATELRL
D
KY
-
-
---
-
-
-PL
N
V
L
I
V
D
D
I
K
PY
K
E
R
K
VAI
LNG
A
H
TA
L
VPVAFQ
A
G
LD
T
V
G
E
A
M
N
D
AEI
C
A
FV
EK
AI
Y
EE
II
P
V
L
D
LP
R
-
D
E
L
ES
F
A
SA
VT
G
RF
R
NP
Y
I
KHQ
LLS
IA
LN
G
MT
K
FRTRI
LPQ
-
LLAG
Q
K
-
--
A
NGT
L
P
AR
L
TFAL
A
ALIAF
YR
G
-
E
RN
G
ETYP
V
Q
D
D
A
HW
L
E
R
Y
QQL
W
S
Q
HR
DRVIG
TQ
E
L
V
A
IV
L
A
E
KDH
W
E
Q
DL
T
Q
V
P
G
L
V
E
Q
V
AN
D
L
DA
I
L
E
K
G
M
REAVR
P
LC
fig|595496.3.peg.1478
Escherichia coli BW2952
MKTLNRRDFPGAQ
Y
P
E
RI
IQ
FG
E
G
N
F
L
RA
FVDW
Q
I
D
L
L
N
E
H
TD
L
NS
G
VVV
V
R
P
IE
T
S
-
--
F
PPS
L
ST
Q
DG
LYT
T
I
IRGLN
EKG
E
AV
SDA
R
L
I
R
SV
N
REI
S
V
Y
S
E
Y
D
E---
F
L
KLAHN
P
E
M
RF
V
FSN
T
TE
A
G
IS
Y
H
-
A
G
D
K
F
D
-
D
A
P
A
V
S
Y
--
-
--
--
P
A
KL
T
R
L
L
F
E
RF
SH
FNG
A
LD
K
G
WII
I
P
C
EL
I
DY
NG
DA
L
R
E
L
VL
R
Y
AQ
E
W
A
L
PE
AFI
Q
W
L
D
Q
A
N
SF
C
S
T
L
VDRIV
TGYP
R
D
E
V
A
KL
E
E
E
LG
Y
HD
GFLD
T
A
E
H
F
Y
LF
VI
QGPKSLATELRL
D
KY
-
-
---
-
-
-PL
N
V
L
I
V
D
D
I
K
PY
K
E
R
K
VAI
LNG
A
H
TA
L
VPVAFQ
A
G
LD
T
V
G
E
A
M
N
D
AEI
C
A
FV
EK
AI
Y
EE
II
P
V
L
D
LP
R
-
D
E
L
ES
F
A
SA
VT
G
RF
R
NP
Y
I
KHQ
LLS
IA
LN
G
MT
K
FRTRI
LPQ
-
LLAG
Q
K
-
--
A
NGT
L
P
AR
L
TFAL
A
ALIAF
YR
G
-
E
RN
G
ETYP
V
Q
D
D
A
HW
L
E
R
Y
QQL
W
S
Q
HR
DRVIG
TQ
E
L
V
A
IV
L
A
E
KDH
W
E
Q
DL
T
Q
V
P
G
L
V
E
Q
V
AN
D
L
DA
I
L
E
K
G
M
REAVR
P
LC
fig|536056.3.peg.2235
Escherichia coli DH1
MKTLNRRDFPGAQ
Y
P
E
RI
IQ
FG
E
G
N
F
L
RA
FVDW
Q
I
D
L
L
N
E
H
TD
L
NS
G
VVV
V
R
P
IE
T
S
-
--
F
PPS
L
ST
Q
DG
LYT
T
I
IRGLN
EKG
E
AV
SDA
R
L
I
R
SV
N
REI
S
V
Y
S
E
Y
D
E---
F
L
KLAHN
P
E
M
RF
V
FSN
T
TE
A
G
IS
Y
H
-
A
G
D
K
F
D
-
D
A
P
A
V
S
Y
--
-
--
--
P
A
KL
T
R
L
L
F
E
RF
SH
FNG
A
LD
K
G
WII
I
P
C
EL
I
DY
NG
DA
L
R
E
L
VL
R
Y
AQ
E
W
A
L
PE
AFI
Q
W
L
D
Q
A
N
SF
C
S
T
L
VDRIV
TGYP
R
D
E
V
A
KL
E
E
E
LG
Y
HD
GFLD
T
A
E
H
F
Y
LF
VI
QGPKSLATELRL
D
KY
-
-
---
-
-
-PL
N
V
L
I
V
D
D
I
K
PY
K
E
R
K
VAI
LNG
A
H
TA
L
VPVAFQ
A
G
LD
T
V
G
E
A
M
N
D
AEI
C
A
FV
EK
AI
Y
EE
II
P
V
L
D
LP
R
-
D
E
L
ES
F
A
SA
VT
G
RF
R
NP
Y
I
KHQ
LLS
IA
LN
G
MT
K
FRTRI
LPQ
-
LLAG
Q
K
-
--
A
NGT
L
P
AR
L
TFAL
A
ALIAF
YR
G
-
E
RN
G
ETYP
V
Q
D
D
A
HW
L
E
R
Y
QQL
W
S
Q
HR
DRVIG
TQ
E
L
V
A
IV
L
A
E
KDH
W
E
Q
DL
T
Q
V
P
G
L
V
E
Q
V
AN
D
L
DA
I
L
E
K
G
M
REAVR
P
LC
fig|562.375.peg.3854
Escherichia coli EC4100B
MKTLNRRDFPGAQ
Y
P
E
RI
IQ
FG
E
G
N
F
L
RA
FVDW
Q
I
D
L
L
N
E
H
TD
L
NS
G
VVV
V
R
P
IE
T
S
-
--
F
PPS
L
ST
Q
DG
LYT
T
I
IRGLN
EKG
E
AV
SDA
R
L
I
R
SV
N
REI
S
V
Y
S
E
Y
D
E---
F
L
KLAHN
P
E
M
RF
V
FSN
T
TE
A
G
IS
Y
H
-
A
G
D
K
F
D
-
D
A
P
A
V
S
Y
--
-
--
--
P
A
KL
T
R
L
L
F
E
RF
SH
FNG
A
LD
K
G
WII
I
P
C
EL
I
DY
NG
DA
L
R
E
L
VL
R
Y
AQ
E
W
A
L
PE
AFI
Q
W
L
D
Q
A
N
SF
C
S
T
L
VDRIV
TGYP
R
D
E
V
A
KL
E
E
E
LG
Y
HD
GFLD
T
A
E
H
F
Y
LF
VI
QGPKSLATELRL
D
KY
-
-
---
-
-
-PL
N
V
L
I
V
D
D
I
K
PY
K
E
R
K
VAI
LNG
A
H
TA
L
VPVAFQ
A
G
LD
T
V
G
E
A
M
N
D
AEI
C
A
FV
EK
AI
Y
EE
II
P
V
L
D
LP
R
-
D
E
L
ES
F
A
SA
VT
G
RF
R
NP
Y
I
KHQ
LLS
IA
LN
G
MT
K
FRTRI
LPQ
-
LLAG
Q
K
-
--
A
NGT
L
P
AR
L
TFAL
A
ALIAF
YR
G
-
E
RN
G
ETYP
V
Q
D
D
A
HW
L
E
R
Y
QQL
W
S
Q
HR
DRVIG
TQ
E
L
V
A
IV
L
A
E
KDH
W
E
Q
DL
T
Q
V
P
G
L
V
E
Q
V
AN
D
L
DA
I
L
E
K
G
M
REAVR
P
LC
fig|316401.4.peg.1831
Escherichia coli ETEC H10407
MKTLNRRDFPGAQ
Y
P
E
RI
IQ
FG
E
G
N
F
L
RA
FVDW
Q
I
D
L
L
N
E
H
TD
L
NS
G
VVV
V
R
P
IE
T
S
-
--
F
PPS
L
ST
Q
DG
LYT
T
I
IRGLN
EKG
E
AV
SDA
R
L
I
R
SV
N
REI
S
V
Y
S
E
Y
D
E---
F
L
KLAHN
P
E
M
RF
V
FSN
T
TE
A
G
IS
Y
H
-
A
G
D
K
F
D
-
D
A
P
A
V
S
Y
--
-
--
--
P
A
KL
T
R
L
L
F
E
RF
SH
FNG
A
LD
K
G
WII
I
P
C
EL
I
DY
NG
DA
L
R
E
L
VL
R
Y
AQ
E
W
A
L
PE
AFI
Q
W
L
D
Q
A
N
SF
C
S
T
L
VDRIV
TGYP
R
D
E
V
A
KL
E
E
E
LG
Y
HD
GFLD
T
A
E
H
F
Y
LF
VI
QGPKSLATELRL
D
KY
-
-
---
-
-
-PL
N
V
L
I
V
D
D
I
K
PY
K
E
R
K
VAI
LNG
A
H
TA
L
VPVAFQ
A
G
LD
T
V
G
E
A
M
N
D
AEI
C
A
FV
EK
AI
Y
EE
II
P
V
L
D
LP
R
-
D
E
L
ES
F
A
SA
VT
G
RF
R
NP
Y
I
KHQ
LLS
IA
LN
G
MT
K
FRTRI
LPQ
-
LLAG
Q
K
-
--
A
NGT
L
P
AR
L
TFAL
A
ALIAF
YR
G
-
E
RN
G
ETYP
V
Q
D
D
A
HW
L
E
R
Y
QQL
W
S
Q
HR
DRVIG
TQ
E
L
V
A
IV
L
A
E
KDH
W
E
Q
DL
T
Q
V
P
G
L
V
E
Q
V
AN
D
L
DA
I
L
E
K
G
M
REAVR
P
LC
fig|656414.3.peg.1817
Escherichia coli H736
MKTLNRRDFPGAQ
Y
P
E
RI
IQ
FG
E
G
N
F
L
RA
FVDW
Q
I
D
L
L
N
E
H
TD
L
NS
G
VVV
V
R
P
IE
T
S
-
--
F
PPS
L
ST
Q
DG
LYT
T
I
IRGLN
EKG
E
AV
SDA
R
L
I
R
SV
N
REI
S
V
Y
S
E
Y
D
E---
F
L
KLAHN
P
E
M
RF
V
FSN
T
TE
A
G
IS
Y
H
-
A
G
D
K
F
D
-
D
A
P
A
V
S
Y
--
-
--
--
P
A
KL
T
R
L
L
F
E
RF
SH
FNG
A
LD
K
G
WII
I
P
C
EL
I
DY
NG
DA
L
R
E
L
VL
R
Y
AQ
E
W
A
L
PE
AFI
Q
W
L
D
Q
A
N
SF
C
S
T
L
VDRIV
TGYP
R
D
E
V
A
KL
E
E
E
LG
Y
HD
GFLD
T
A
E
H
F
Y
LF
VI
QGPKSLATELRL
D
KY
-
-
---
-
-
-PL
N
V
L
I
V
D
D
I
K
PY
K
E
R
K
VAI
LNG
A
H
TA
L
VPVAFQ
A
G
LD
T
V
G
E
A
M
N
D
AEI
C
A
FV
EK
AI
Y
EE
II
P
V
L
D
LP
R
-
D
E
L
ES
F
A
SA
VT
G
RF
R
NP
Y
I
KHQ
LLS
IA
LN
G
MT
K
FRTRI
LPQ
-
LLAG
Q
K
-
--
A
NGT
L
P
AR
L
TFAL
A
ALIAF
YR
G
-
E
RN
G
ETYP
V
Q
D
D
A
HW
L
E
R
Y
QQL
W
S
Q
HR
DRVIG
TQ
E
L
V
A
IV
L
A
E
KDH
W
E
Q
DL
T
Q
V
P
G
L
V
E
Q
V
AN
D
L
DA
I
L
E
K
G
M
REAVR
P
LC
fig|656419.3.peg.2203
Escherichia coli M718
MKTLNRRDFPGAQ
Y
P
E
RI
IQ
FG
E
G
N
F
L
RA
FVDW
Q
I
D
L
L
N
E
H
TD
L
NS
G
VVV
V
R
P
IE
T
S
-
--
F
PPS
L
ST
Q
DG
LYT
T
I
IRGLN
EKG
E
AV
SDA
R
L
I
R
SV
N
REI
S
V
Y
S
E
Y
D
E---
F
L
KLAHN
P
E
M
RF
V
FSN
T
TE
A
G
IS
Y
H
-
A
G
D
K
F
D
-
D
A
P
A
V
S
Y
--
-
--
--
P
A
KL
T
R
L
L
F
E
RF
SH
FNG
A
LD
K
G
WII
I
P
C
EL
I
DY
NG
DA
L
R
E
L
VL
R
Y
AQ
E
W
A
L
PE
AFI
Q
W
L
D
Q
A
N
SF
C
S
T
L
VDRIV
TGYP
R
D
E
V
A
KL
E
E
E
LG
Y
HD
GFLD
T
A
E
H
F
Y
LF
VI
QGPKSLATELRL
D
KY
-
-
---
-
-
-PL
N
V
L
I
V
D
D
I
K
PY
K
E
R
K
VAI
LNG
A
H
TA
L
VPVAFQ
A
G
LD
T
V
G
E
A
M
N
D
AEI
C
A
FV
EK
AI
Y
EE
II
P
V
L
D
LP
R
-
D
E
L
ES
F
A
SA
VT
G
RF
R
NP
Y
I
KHQ
LLS
IA
LN
G
MT
K
FRTRI
LPQ
-
LLAG
Q
K
-
--
A
NGT
L
P
AR
L
TFAL
A
ALIAF
YR
G
-
E
RN
G
ETYP
V
Q
D
D
A
HW
L
E
R
Y
QQL
W
S
Q
HR
DRVIG
TQ
E
L
V
A
IV
L
A
E
KDH
W
E
Q
DL
T
Q
V
P
G
L
V
E
Q
V
AN
D
L
DA
I
L
E
K
G
M
REAVR
P
LC
fig|749537.3.peg.1551
Escherichia coli MS 115-1
MKTLNRRDFPGAQ
Y
P
E
RI
IQ
FG
E
G
N
F
L
RA
FVDW
Q
I
D
L
L
N
E
H
TD
L
NS
G
VVV
V
R
P
IE
T
S
-
--
F
PPS
L
ST
Q
DG
LYT
T
I
IRGLN
EKG
E
AV
SDA
R
L
I
R
SV
N
REI
S
V
Y
S
E
Y
D
E---
F
L
KLAHN
P
E
M
RF
V
FSN
T
TE
A
G
IS
Y
H
-
A
G
D
K
F
D
-
D
A
P
A
V
S
Y
--
-
--
--
P
A
KL
T
R
L
L
F
E
RF
SH
FNG
A
LD
K
G
WII
I
P
C
EL
I
DY
NG
DA
L
R
E
L
VL
R
Y
AQ
E
W
A
L
PE
AFI
Q
W
L
D
Q
A
N
SF
C
S
T
L
VDRIV
TGYP
R
D
E
V
A
KL
E
E
E
LG
Y
HD
GFLD
T
A
E
H
F
Y
LF
VI
QGPKSLATELRL
D
KY
-
-
---
-
-
-PL
N
V
L
I
V
D
D
I
K
PY
K
E
R
K
VAI
LNG
A
H
TA
L
VPVAFQ
A
G
LD
T
V
G
E
A
M
N
D
AEI
C
A
FV
EK
AI
Y
EE
II
P
V
L
D
LP
R
-
D
E
L
ES
F
A
SA
VT
G
RF
R
NP
Y
I
KHQ
LLS
IA
LN
G
MT
K
FRTRI
LPQ
-
LLAG
Q
K
-
--
A
NGT
L
P
AR
L
TFAL
A
ALIAF
YR
G
-
E
RN
G
ETYP
V
Q
D
D
A
HW
L
E
R
Y
QQL
W
S
Q
HR
DRVIG
TQ
E
L
V
A
IV
L
A
E
KDH
W
E
Q
DL
T
Q
V
P
G
L
V
E
Q
V
AN
D
L
DA
I
L
E
K
G
M
REAVR
P
LC
fig|749538.3.peg.4103
Escherichia coli MS 116-1
MKTLNRRDFPGAQ
Y
P
E
RI
IQ
FG
E
G
N
F
L
RA
FVDW
Q
I
D
L
L
N
E
H
TD
L
NS
G
VVV
V
R
P
IE
T
S
-
--
F
PPS
L
ST
Q
DG
LYT
T
I
IRGLN
EKG
E
AV
SDA
R
L
I
R
SV
N
REI
S
V
Y
S
E
Y
D
E---
F
L
KLAHN
P
E
M
RF
V
FSN
T
TE
A
G
IS
Y
H
-
A
G
D
K
F
D
-
D
A
P
A
V
S
Y
--
-
--
--
P
A
KL
T
R
L
L
F
E
RF
SH
FNG
A
LD
K
G
WII
I
P
C
EL
I
DY
NG
DA
L
R
E
L
VL
R
Y
AQ
E
W
A
L
PE
AFI
Q
W
L
D
Q
A
N
SF
C
S
T
L
VDRIV
TGYP
R
D
E
V
A
KL
E
E
E
LG
Y
HD
GFLD
T
A
E
H
F
Y
LF
VI
QGPKSLATELRL
D
KY
-
-
---
-
-
-PL
N
V
L
I
V
D
D
I
K
PY
K
E
R
K
VAI
LNG
A
H
TA
L
VPVAFQ
A
G
LD
T
V
G
E
A
M
N
D
AEI
C
A
FV
EK
AI
Y
EE
II
P
V
L
D
LP
R
-
D
E
L
ES
F
A
SA
VT
G
RF
R
NP
Y
I
KHQ
LLS
IA
LN
G
MT
K
FRTRI
LPQ
-
LLAG
Q
K
-
--
A
NGT
L
P
AR
L
TFAL
A
ALIAF
YR
G
-
E
RN
G
ETYP
V
Q
D
D
A
HW
L
E
R
Y
QQL
W
S
Q
HR
DRVIG
TQ
E
L
V
A
IV
L
A
E
KDH
W
E
Q
DL
T
Q
V
P
G
L
V
E
Q
V
AN
D
L
DA
I
L
E
K
G
M
REAVR
P
LC
fig|749540.3.peg.1271
Escherichia coli MS 146-1
MKTLNRRDFPGAQ
Y
P
E
RI
IQ
FG
E
G
N
F
L
RA
FVDW
Q
I
D
L
L
N
E
H
TD
L
NS
G
VVV
V
R
P
IE
T
S
-
--
F
PPS
L
ST
Q
DG
LYT
T
I
IRGLN
EKG
E
AV
SDA
R
L
I
R
SV
N
REI
S
V
Y
S
E
Y
D
E---
F
L
KLAHN
P
E
M
RF
V
FSN
T
TE
A
G
IS
Y
H
-
A
G
D
K
F
D
-
D
A
P
A
V
S
Y
--
-
--
--
P
A
KL
T
R
L
L
F
E
RF
SH
FNG
A
LD
K
G
WII
I
P
C
EL
I
DY
NG
DA
L
R
E
L
VL
R
Y
AQ
E
W
A
L
PE
AFI
Q
W
L
D
Q
A
N
SF
C
S
T
L
VDRIV
TGYP
R
D
E
V
A
KL
E
E
E
LG
Y
HD
GFLD
T
A
E
H
F
Y
LF
VI
QGPKSLATELRL
D
KY
-
-
---
-
-
-PL
N
V
L
I
V
D
D
I
K
PY
K
E
R
K
VAI
LNG
A
H
TA
L
VPVAFQ
A
G
LD
T
V
G
E
A
M
N
D
AEI
C
A
FV
EK
AI
Y
EE
II
P
V
L
D
LP
R
-
D
E
L
ES
F
A
SA
VT
G
RF
R
NP
Y
I
KHQ
LLS
IA
LN
G
MT
K
FRTRI
LPQ
-
LLAG
Q
K
-
--
A
NGT
L
P
AR
L
TFAL
A
ALIAF
YR
G
-
E
RN
G
ETYP
V
Q
D
D
A
HW
L
E
R
Y
QQL
W
S
Q
HR
DRVIG
TQ
E
L
V
A
IV
L
A
E
KDH
W
E
Q
DL
T
Q
V
P
G
L
V
E
Q
V
AN
D
L
DA
I
L
E
K
G
M
REAVR
P
LC
fig|749547.3.peg.1320
Escherichia coli MS 187-1
MKTLNRRDFPGAQ
Y
P
E
RI
IQ
FG
E
G
N
F
L
RA
FVDW
Q
I
D
L
L
N
E
H
TD
L
NS
G
VVV
V
R
P
IE
T
S
-
--
F
PPS
L
ST
Q
DG
LYT
T
I
IRGLN
EKG
E
AV
SDA
R
L
I
R
SV
N
REI
S
V
Y
S
E
Y
D
E---
F
L
KLAHN
P
E
M
RF
V
FSN
T
TE
A
G
IS
Y
H
-
A
G
D
K
F
D
-
D
A
P
A
V
S
Y
--
-
--
--
P
A
KL
T
R
L
L
F
E
RF
SH
FNG
A
LD
K
G
WII
I
P
C
EL
I
DY
NG
DA
L
R
E
L
VL
R
Y
AQ
E
W
A
L
PE
AFI
Q
W
L
D
Q
A
N
SF
C
S
T
L
VDRIV
TGYP
R
D
E
V
A
KL
E
E
E
LG
Y
HD
GFLD
T
A
E
H
F
Y
LF
VI
QGPKSLATELRL
D
KY
-
-
---
-
-
-PL
N
V
L
I
V
D
D
I
K
PY
K
E
R
K
VAI
LNG
A
H
TA
L
VPVAFQ
A
G
LD
T
V
G
E
A
M
N
D
AEI
C
A
FV
EK
AI
Y
EE
II
P
V
L
D
LP
R
-
D
E
L
ES
F
A
SA
VT
G
RF
R
NP
Y
I
KHQ
LLS
IA
LN
G
MT
K
FRTRI
LPQ
-
LLAG
Q
K
-
--
A
NGT
L
P
AR
L
TFAL
A
ALIAF
YR
G
-
E
RN
G
ETYP
V
Q
D
D
A
HW
L
E
R
Y
QQL
W
S
Q
HR
DRVIG
TQ
E
L
V
A
IV
L
A
E
KDH
W
E
Q
DL
T
Q
V
P
G
L
V
E
Q
V
AN
D
L
DA
I
L
E
K
G
M
REAVR
P
LC
fig|749548.3.peg.1176
Escherichia coli MS 196-1
MKTLNRRDFPGAQ
Y
P
E
RI
IQ
FG
E
G
N
F
L
RA
FVDW
Q
I
D
L
L
N
E
H
TD
L
NS
G
VVV
V
R
P
IE
T
S
-
--
F
PPS
L
ST
Q
DG
LYT
T
I
IRGLN
EKG
E
AV
SDA
R
L
I
R
SV
N
REI
S
V
Y
S
E
Y
D
E---
F
L
KLAHN
P
E
M
RF
V
FSN
T
TE
A
G
IS
Y
H
-
A
G
D
K
F
D
-
D
A
P
A
V
S
Y
--
-
--
--
P
A
KL
T
R
L
L
F
E
RF
SH
FNG
A
LD
K
G
WII
I
P
C
EL
I
DY
NG
DA
L
R
E
L
VL
R
Y
AQ
E
W
A
L
PE
AFI
Q
W
L
D
Q
A
N
SF
C
S
T
L
VDRIV
TGYP
R
D
E
V
A
KL
E
E
E
LG
Y
HD
GFLD
T
A
E
H
F
Y
LF
VI
QGPKSLATELRL
D
KY
-
-
---
-
-
-PL
N
V
L
I
V
D
D
I
K
PY
K
E
R
K
VAI
LNG
A
H
TA
L
VPVAFQ
A
G
LD
T
V
G
E
A
M
N
D
AEI
C
A
FV
EK
AI
Y
EE
II
P
V
L
D
LP
R
-
D
E
L
ES
F
A
SA
VT
G
RF
R
NP
Y
I
KHQ
LLS
IA
LN
G
MT
K
FRTRI
LPQ
-
LLAG
Q
K
-
--
A
NGT
L
P
AR
L
TFAL
A
ALIAF
YR
G
-
E
RN
G
ETYP
V
Q
D
D
A
HW
L
E
R
Y
QQL
W
S
Q
HR
DRVIG
TQ
E
L
V
A
IV
L
A
E
KDH
W
E
Q
DL
T
Q
V
P
G
L
V
E
Q
V
AN
D
L
DA
I
L
E
K
G
M
REAVR
P
LC
fig|585395.4.peg.1729
Escherichia coli O103:H2 str. 12009
MKTLNRRDFPGAQ
Y
P
E
RI
IQ
FG
E
G
N
F
L
RA
FVDW
Q
I
D
L
L
N
E
H
TD
L
NS
G
VVV
V
R
P
IE
T
S
-
--
F
PPS
L
ST
Q
DG
LYT
T
I
IRGLN
EKG
E
AV
SDA
R
L
I
R
SV
N
REI
S
V
Y
S
E
Y
D
E---
F
L
KLAHN
P
E
M
RF
V
FSN
T
TE
A
G
IS
Y
H
-
A
G
D
K
F
D
-
D
A
P
A
V
S
Y
--
-
--
--
P
A
KL
T
R
L
L
F
E
RF
SH
FNG
A
LD
K
G
WII
I
P
C
EL
I
DY
NG
DA
L
R
E
L
VL
R
Y
AQ
E
W
A
L
PE
AFI
Q
W
L
D
Q
A
N
SF
C
S
T
L
VDRIV
TGYP
R
D
E
V
A
KL
E
E
E
LG
Y
HD
GFLD
T
A
E
H
F
Y
LF
VI
QGPKSLATELRL
D
KY
-
-
---
-
-
-PL
N
V
L
I
V
D
D
I
K
PY
K
E
R
K
VAI
LNG
A
H
TA
L
VPVAFQ
A
G
LD
T
V
G
E
A
M
N
D
AEI
C
A
FV
EK
AI
Y
EE
II
P
V
L
D
LP
R
-
D
E
L
ES
F
A
SA
VT
G
RF
R
NP
Y
I
KHQ
LLS
IA
LN
G
MT
K
FRTRI
LPQ
-
LLAG
Q
K
-
--
A
NGT
L
P
AR
L
TFAL
A
ALIAF
YR
G
-
E
RN
G
ETYP
V
Q
D
D
A
HW
L
E
R
Y
QQL
W
S
Q
HR
DRVIG
TQ
E
L
V
A
IV
L
A
E
KDH
W
E
Q
DL
T
Q
V
P
G
L
V
E
Q
V
AN
D
L
DA
I
L
E
K
G
M
REAVR
P
LC
fig|83334.1.peg.2155
Escherichia coli O157:H7
MKTLNRRDFPGAQ
Y
P
E
RI
IQ
FG
E
G
N
F
L
RA
FVDW
Q
I
D
L
L
N
E
H
TD
L
NS
G
VVV
V
R
P
IE
T
S
-
--
F
PPS
L
ST
Q
DG
LYT
T
I
IRGLN
EKG
E
AV
SDA
R
L
I
R
SV
N
REI
S
V
Y
S
E
Y
D
E---
F
L
KLAHN
P
E
M
RF
V
FSN
T
TE
A
G
IS
Y
H
-
A
G
D
K
F
D
-
D
A
P
A
V
S
Y
--
-
--
--
P
A
KL
T
R
L
L
F
E
RF
SH
FNG
A
LD
K
G
WII
I
P
C
EL
I
DY
NG
DA
L
R
E
L
VL
R
Y
AQ
E
W
A
L
PE
AFI
Q
W
L
D
Q
A
N
SF
C
S
T
L
VDRIV
TGYP
R
D
E
V
A
KL
E
E
E
LG
Y
HD
GFLD
T
A
E
H
F
Y
LF
VI
QGPKSLATELRL
D
KY
-
-
---
-
-
-PL
N
V
L
I
V
D
D
I
K
PY
K
E
R
K
VAI
LNG
A
H
TA
L
VPVAFQ
A
G
LD
T
V
G
E
A
M
N
D
AEI
C
A
FV
EK
AI
Y
EE
II
P
V
L
D
LP
R
-
D
E
L
ES
F
A
SA
VT
G
RF
R
NP
Y
I
KHQ
LLS
IA
LN
G
MT
K
FRTRI
LPQ
-
LLAG
Q
K
-
--
A
NGT
L
P
AR
L
TFAL
A
ALIAF
YR
G
-
E
RN
G
ETYP
V
Q
D
D
A
HW
L
E
R
Y
QQL
W
S
Q
HR
DRVIG
TQ
E
L
V
A
IV
L
A
E
KDH
W
E
Q
DL
T
Q
V
P
G
L
V
E
Q
V
AN
D
L
DA
I
L
E
K
G
M
REAVR
P
LC
fig|444454.5.peg.1037
Escherichia coli O157:H7 str. EC4024
MKTLNRRDFPGAQ
Y
P
E
RI
IQ
FG
E
G
N
F
L
RA
FVDW
Q
I
D
L
L
N
E
H
TD
L
NS
G
VVV
V
R
P
IE
T
S
-
--
F
PPS
L
ST
Q
DG
LYT
T
I
IRGLN
EKG
E
AV
SDA
R
L
I
R
SV
N
REI
S
V
Y
S
E
Y
D
E---
F
L
KLAHN
P
E
M
RF
V
FSN
T
TE
A
G
IS
Y
H
-
A
G
D
K
F
D
-
D
A
P
A
V
S
Y
--
-
--
--
P
A
KL
T
R
L
L
F
E
RF
SH
FNG
A
LD
K
G
WII
I
P
C
EL
I
DY
NG
DA
L
R
E
L
VL
R
Y
AQ
E
W
A
L
PE
AFI
Q
W
L
D
Q
A
N
SF
C
S
T
L
VDRIV
TGYP
R
D
E
V
A
KL
E
E
E
LG
Y
HD
GFLD
T
A
E
H
F
Y
LF
VI
QGPKSLATELRL
D
KY
-
-
---
-
-
-PL
N
V
L
I
V
D
D
I
K
PY
K
E
R
K
VAI
LNG
A
H
TA
L
VPVAFQ
A
G
LD
T
V
G
E
A
M
N
D
AEI
C
A
FV
EK
AI
Y
EE
II
P
V
L
D
LP
R
-
D
E
L
ES
F
A
SA
VT
G
RF
R
NP
Y
I
KHQ
LLS
IA
LN
G
MT
K
FRTRI
LPQ
-
LLAG
Q
K
-
--
A
NGT
L
P
AR
L
TFAL
A
ALIAF
YR
G
-
E
RN
G
ETYP
V
Q
D
D
A
HW
L
E
R
Y
QQL
W
S
Q
HR
DRVIG
TQ
E
L
V
A
IV
L
A
E
KDH
W
E
Q
DL
T
Q
V
P
G
L
V
E
Q
V
AN
D
L
DA
I
L
E
K
G
M
REAVR
P
LC
fig|444449.5.peg.362
Escherichia coli O157:H7 str. EC4042
MKTLNRRDFPGAQ
Y
P
E
RI
IQ
FG
E
G
N
F
L
RA
FVDW
Q
I
D
L
L
N
E
H
TD
L
NS
G
VVV
V
R
P
IE
T
S
-
--
F
PPS
L
ST
Q
DG
LYT
T
I
IRGLN
EKG
E
AV
SDA
R
L
I
R
SV
N
REI
S
V
Y
S
E
Y
D
E---
F
L
KLAHN
P
E
M
RF
V
FSN
T
TE
A
G
IS
Y
H
-
A
G
D
K
F
D
-
D
A
P
A
V
S
Y
--
-
--
--
P
A
KL
T
R
L
L
F
E
RF
SH
FNG
A
LD
K
G
WII
I
P
C
EL
I
DY
NG
DA
L
R
E
L
VL
R
Y
AQ
E
W
A
L
PE
AFI
Q
W
L
D
Q
A
N
SF
C
S
T
L
VDRIV
TGYP
R
D
E
V
A
KL
E
E
E
LG
Y
HD
GFLD
T
A
E
H
F
Y
LF
VI
QGPKSLATELRL
D
KY
-
-
---
-
-
-PL
N
V
L
I
V
D
D
I
K
PY
K
E
R
K
VAI
LNG
A
H
TA
L
VPVAFQ
A
G
LD
T
V
G
E
A
M
N
D
AEI
C
A
FV
EK
AI
Y
EE
II
P
V
L
D
LP
R
-
D
E
L
ES
F
A
SA
VT
G
RF
R
NP
Y
I
KHQ
LLS
IA
LN
G
MT
K
FRTRI
LPQ
-
LLAG
Q
K
-
--
A
NGT
L
P
AR
L
TFAL
A
ALIAF
YR
G
-
E
RN
G
ETYP
V
Q
D
D
A
HW
L
E
R
Y
QQL
W
S
Q
HR
DRVIG
TQ
E
L
V
A
IV
L
A
E
KDH
W
E
Q
DL
T
Q
V
P
G
L
V
E
Q
V
AN
D
L
DA
I
L
E
K
G
M
REAVR
P
LC
fig|444448.5.peg.4721
Escherichia coli O157:H7 str. EC4045
MKTLNRRDFPGAQ
Y
P
E
RI
IQ
FG
E
G
N
F
L
RA
FVDW
Q
I
D
L
L
N
E
H
TD
L
NS
G
VVV
V
R
P
IE
T
S
-
--
F
PPS
L
ST
Q
DG
LYT
T
I
IRGLN
EKG
E
AV
SDA
R
L
I
R
SV
N
REI
S
V
Y
S
E
Y
D
E---
F
L
KLAHN
P
E
M
RF
V
FSN
T
TE
A
G
IS
Y
H
-
A
G
D
K
F
D
-
D
A
P
A
V
S
Y
--
-
--
--
P
A
KL
T
R
L
L
F
E
RF
SH
FNG
A
LD
K
G
WII
I
P
C
EL
I
DY
NG
DA
L
R
E
L
VL
R
Y
AQ
E
W
A
L
PE
AFI
Q
W
L
D
Q
A
N
SF
C
S
T
L
VDRIV
TGYP
R
D
E
V
A
KL
E
E
E
LG
Y
HD
GFLD
T
A
E
H
F
Y
LF
VI
QGPKSLATELRL
D
KY
-
-
---
-
-
-PL
N
V
L
I
V
D
D
I
K
PY
K
E
R
K
VAI
LNG
A
H
TA
L
VPVAFQ
A
G
LD
T
V
G
E
A
M
N
D
AEI
C
A
FV
EK
AI
Y
EE
II
P
V
L
D
LP
R
-
D
E
L
ES
F
A
SA
VT
G
RF
R
NP
Y
I
KHQ
LLS
IA
LN
G
MT
K
FRTRI
LPQ
-
LLAG
Q
K
-
--
A
NGT
L
P
AR
L
TFAL
A
ALIAF
YR
G
-
E
RN
G
ETYP
V
Q
D
D
A
HW
L
E
R
Y
QQL
W
S
Q
HR
DRVIG
TQ
E
L
V
A
IV
L
A
E
KDH
W
E
Q
DL
T
Q
V
P
G
L
V
E
Q
V
AN
D
L
DA
I
L
E
K
G
M
REAVR
P
LC
fig|444453.5.peg.2917
Escherichia coli O157:H7 str. EC4076
MKTLNRRDFPGAQ
Y
P
E
RI
IQ
FG
E
G
N
F
L
RA
FVDW
Q
I
D
L
L
N
E
H
TD
L
NS
G
VVV
V
R
P
IE
T
S
-
--
F
PPS
L
ST
Q
DG
LYT
T
I
IRGLN
EKG
E
AV
SDA
R
L
I
R
SV
N
REI
S
V
Y
S
E
Y
D
E---
F
L
KLAHN
P
E
M
RF
V
FSN
T
TE
A
G
IS
Y
H
-
A
G
D
K
F
D
-
D
A
P
A
V
S
Y
--
-
--
--
P
A
KL
T
R
L
L
F
E
RF
SH
FNG
A
LD
K
G
WII
I
P
C
EL
I
DY
NG
DA
L
R
E
L
VL
R
Y
AQ
E
W
A
L
PE
AFI
Q
W
L
D
Q
A
N
SF
C
S
T
L
VDRIV
TGYP
R
D
E
V
A
KL
E
E
E
LG
Y
HD
GFLD
T
A
E
H
F
Y
LF
VI
QGPKSLATELRL
D
KY
-
-
---
-
-
-PL
N
V
L
I
V
D
D
I
K
PY
K
E
R
K
VAI
LNG
A
H
TA
L
VPVAFQ
A
G
LD
T
V
G
E
A
M
N
D
AEI
C
A
FV
EK
AI
Y
EE
II
P
V
L
D
LP
R
-
D
E
L
ES
F
A
SA
VT
G
RF
R
NP
Y
I
KHQ
LLS
IA
LN
G
MT
K
FRTRI
LPQ
-
LLAG
Q
K
-
--
A
NGT
L
P
AR
L
TFAL
A
ALIAF
YR
G
-
E
RN
G
ETYP
V
Q
D
D
A
HW
L
E
R
Y
QQL
W
S
Q
HR
DRVIG
TQ
E
L
V
A
IV
L
A
E
KDH
W
E
Q
DL
T
Q
V
P
G
L
V
E
Q
V
AN
D
L
DA
I
L
E
K
G
M
REAVR
P
LC
fig|444452.5.peg.1899
Escherichia coli O157:H7 str. EC4113
MKTLNRRDFPGAQ
Y
P
E
RI
IQ
FG
E
G
N
F
L
RA
FVDW
Q
I
D
L
L
N
E
H
TD
L
NS
G
VVV
V
R
P
IE
T
S
-
--
F
PPS
L
ST
Q
DG
LYT
T
I
IRGLN
EKG
E
AV
SDA
R
L
I
R
SV
N
REI
S
V
Y
S
E
Y
D
E---
F
L
KLAHN
P
E
M
RF
V
FSN
T
TE
A
G
IS
Y
H
-
A
G
D
K
F
D
-
D
A
P
A
V
S
Y
--
-
--
--
P
A
KL
T
R
L
L
F
E
RF
SH
FNG
A
LD
K
G
WII
I
P
C
EL
I
DY
NG
DA
L
R
E
L
VL
R
Y
AQ
E
W
A
L
PE
AFI
Q
W
L
D
Q
A
N
SF
C
S
T
L
VDRIV
TGYP
R
D
E
V
A
KL
E
E
E
LG
Y
HD
GFLD
T
A
E
H
F
Y
LF
VI
QGPKSLATELRL
D
KY
-
-
---
-
-
-PL
N
V
L
I
V
D
D
I
K
PY
K
E
R
K
VAI
LNG
A
H
TA
L
VPVAFQ
A
G
LD
T
V
G
E
A
M
N
D
AEI
C
A
FV
EK
AI
Y
EE
II
P
V
L
D
LP
R
-
D
E
L
ES
F
A
SA
VT
G
RF
R
NP
Y
I
KHQ
LLS
IA
LN
G
MT
K
FRTRI
LPQ
-
LLAG
Q
K
-
--
A
NGT
L
P
AR
L
TFAL
A
ALIAF
YR
G
-
E
RN
G
ETYP
V
Q
D
D
A
HW
L
E
R
Y
QQL
W
S
Q
HR
DRVIG
TQ
E
L
V
A
IV
L
A
E
KDH
W
E
Q
DL
T
Q
V
P
G
L
V
E
Q
V
AN
D
L
DA
I
L
E
K
G
M
REAVR
P
LC
fig|444450.8.peg.2180
Escherichia coli O157:H7 str. EC4115
MKTLNRRDFPGAQ
Y
P
E
RI
IQ
FG
E
G
N
F
L
RA
FVDW
Q
I
D
L
L
N
E
H
TD
L
NS
G
VVV
V
R
P
IE
T
S
-
--
F
PPS
L
ST
Q
DG
LYT
T
I
IRGLN
EKG
E
AV
SDA
R
L
I
R
SV
N
REI
S
V
Y
S
E
Y
D
E---
F
L
KLAHN
P
E
M
RF
V
FSN
T
TE
A
G
IS
Y
H
-
A
G
D
K
F
D
-
D
A
P
A
V
S
Y
--
-
--
--
P
A
KL
T
R
L
L
F
E
RF
SH
FNG
A
LD
K
G
WII
I
P
C
EL
I
DY
NG
DA
L
R
E
L
VL
R
Y
AQ
E
W
A
L
PE
AFI
Q
W
L
D
Q
A
N
SF
C
S
T
L
VDRIV
TGYP
R
D
E
V
A
KL
E
E
E
LG
Y
HD
GFLD
T
A
E
H
F
Y
LF
VI
QGPKSLATELRL
D
KY
-
-
---
-
-
-PL
N
V
L
I
V
D
D
I
K
PY
K
E
R
K
VAI
LNG
A
H
TA
L
VPVAFQ
A
G
LD
T
V
G
E
A
M
N
D
AEI
C
A
FV
EK
AI
Y
EE
II
P
V
L
D
LP
R
-
D
E
L
ES
F
A
SA
VT
G
RF
R
NP
Y
I
KHQ
LLS
IA
LN
G
MT
K
FRTRI
LPQ
-
LLAG
Q
K
-
--
A
NGT
L
P
AR
L
TFAL
A
ALIAF
YR
G
-
E
RN
G
ETYP
V
Q
D
D
A
HW
L
E
R
Y
QQL
W
S
Q
HR
DRVIG
TQ
E
L
V
A
IV
L
A
E
KDH
W
E
Q
DL
T
Q
V
P
G
L
V
E
Q
V
AN
D
L
DA
I
L
E
K
G
M
REAVR
P
LC
fig|444451.5.peg.1892
Escherichia coli O157:H7 str. EC4196
MKTLNRRDFPGAQ
Y
P
E
RI
IQ
FG
E
G
N
F
L
RA
FVDW
Q
I
D
L
L
N
E
H
TD
L
NS
G
VVV
V
R
P
IE
T
S
-
--
F
PPS
L
ST
Q
DG
LYT
T
I
IRGLN
EKG
E
AV
SDA
R
L
I
R
SV
N
REI
S
V
Y
S
E
Y
D
E---
F
L
KLAHN
P
E
M
RF
V
FSN
T
TE
A
G
IS
Y
H
-
A
G
D
K
F
D
-
D
A
P
A
V
S
Y
--
-
--
--
P
A
KL
T
R
L
L
F
E
RF
SH
FNG
A
LD
K
G
WII
I
P
C
EL
I
DY
NG
DA
L
R
E
L
VL
R
Y
AQ
E
W
A
L
PE
AFI
Q
W
L
D
Q
A
N
SF
C
S
T
L
VDRIV
TGYP
R
D
E
V
A
KL
E
E
E
LG
Y
HD
GFLD
T
A
E
H
F
Y
LF
VI
QGPKSLATELRL
D
KY
-
-
---
-
-
-PL
N
V
L
I
V
D
D
I
K
PY
K
E
R
K
VAI
LNG
A
H
TA
L
VPVAFQ
A
G
LD
T
V
G
E
A
M
N
D
AEI
C
A
FV
EK
AI
Y
EE
II
P
V
L
D
LP
R
-
D
E
L
ES
F
A
SA
VT
G
RF
R
NP
Y
I
KHQ
LLS
IA
LN
G
MT
K
FRTRI
LPQ
-
LLAG
Q
K
-
--
A
NGT
L
P
AR
L
TFAL
A
ALIAF
YR
G
-
E
RN
G
ETYP
V
Q
D
D
A
HW
L
E
R
Y
QQL
W
S
Q
HR
DRVIG
TQ
E
L
V
A
IV
L
A
E
KDH
W
E
Q
DL
T
Q
V
P
G
L
V
E
Q
V
AN
D
L
DA
I
L
E
K
G
M
REAVR
P
LC
fig|444447.5.peg.5631
Escherichia coli O157:H7 str. EC4206
MKTLNRRDFPGAQ
Y
P
E
RI
IQ
FG
E
G
N
F
L
RA
FVDW
Q
I
D
L
L
N
E
H
TD
L
NS
G
VVV
V
R
P
IE
T
S
-
--
F
PPS
L
ST
Q
DG
LYT
T
I
IRGLN
EKG
E
AV
SDA
R
L
I
R
SV
N
REI
S
V
Y
S
E
Y
D
E---
F
L
KLAHN
P
E
M
RF
V
FSN
T
TE
A
G
IS
Y
H
-
A
G
D
K
F
D
-
D
A
P
A
V
S
Y
--
-
--
--
P
A
KL
T
R
L
L
F
E
RF
SH
FNG
A
LD
K
G
WII
I
P
C
EL
I
DY
NG
DA
L
R
E
L
VL
R
Y
AQ
E
W
A
L
PE
AFI
Q
W
L
D
Q
A
N
SF
C
S
T
L
VDRIV
TGYP
R
D
E
V
A
KL
E
E
E
LG
Y
HD
GFLD
T
A
E
H
F
Y
LF
VI
QGPKSLATELRL
D
KY
-
-
---
-
-
-PL
N
V
L
I
V
D
D
I
K
PY
K
E
R
K
VAI
LNG
A
H
TA
L
VPVAFQ
A
G
LD
T
V
G
E
A
M
N
D
AEI
C
A
FV
EK
AI
Y
EE
II
P
V
L
D
LP
R
-
D
E
L
ES
F
A
SA
VT
G
RF
R
NP
Y
I
KHQ
LLS
IA
LN
G
MT
K
FRTRI
LPQ
-
LLAG
Q
K
-
--
A
NGT
L
P
AR
L
TFAL
A
ALIAF
YR
G
-
E
RN
G
ETYP
V
Q
D
D
A
HW
L
E
R
Y
QQL
W
S
Q
HR
DRVIG
TQ
E
L
V
A
IV
L
A
E
KDH
W
E
Q
DL
T
Q
V
P
G
L
V
E
Q
V
AN
D
L
DA
I
L
E
K
G
M
REAVR
P
LC
fig|478004.5.peg.2906
Escherichia coli O157:H7 str. EC4401
MKTLNRRDFPGAQ
Y
P
E
RI
IQ
FG
E
G
N
F
L
RA
FVDW
Q
I
D
L
L
N
E
H
TD
L
NS
G
VVV
V
R
P
IE
T
S
-
--
F
PPS
L
ST
Q
DG
LYT
T
I
IRGLN
EKG
E
AV
SDA
R
L
I
R
SV
N
REI
S
V
Y
S
E
Y
D
E---
F
L
KLAHN
P
E
M
RF
V
FSN
T
TE
A
G
IS
Y
H
-
A
G
D
K
F
D
-
D
A
P
A
V
S
Y
--
-
--
--
P
A
KL
T
R
L
L
F
E
RF
SH
FNG
A
LD
K
G
WII
I
P
C
EL
I
DY
NG
DA
L
R
E
L
VL
R
Y
AQ
E
W
A
L
PE
AFI
Q
W
L
D
Q
A
N
SF
C
S
T
L
VDRIV
TGYP
R
D
E
V
A
KL
E
E
E
LG
Y
HD
GFLD
T
A
E
H
F
Y
LF
VI
QGPKSLATELRL
D
KY
-
-
---
-
-
-PL
N
V
L
I
V
D
D
I
K
PY
K
E
R
K
VAI
LNG
A
H
TA
L
VPVAFQ
A
G
LD
T
V
G
E
A
M
N
D
AEI
C
A
FV
EK
AI
Y
EE
II
P
V
L
D
LP
R
-
D
E
L
ES
F
A
SA
VT
G
RF
R
NP
Y
I
KHQ
LLS
IA
LN
G
MT
K
FRTRI
LPQ
-
LLAG
Q
K
-
--
A
NGT
L
P
AR
L
TFAL
A
ALIAF
YR
G
-
E
RN
G
ETYP
V
Q
D
D
A
HW
L
E
R
Y
QQL
W
S
Q
HR
DRVIG
TQ
E
L
V
A
IV
L
A
E
KDH
W
E
Q
DL
T
Q
V
P
G
L
V
E
Q
V
AN
D
L
DA
I
L
E
K
G
M
REAVR
P
LC
fig|478005.5.peg.2918
Escherichia coli O157:H7 str. EC4486
MKTLNRRDFPGAQ
Y
P
E
RI
IQ
FG
E
G
N
F
L
RA
FVDW
Q
I
D
L
L
N
E
H
TD
L
NS
G
VVV
V
R
P
IE
T
S
-
--
F
PPS
L
ST
Q
DG
LYT
T
I
IRGLN
EKG
E
AV
SDA
R
L
I
R
SV
N
REI
S
V
Y
S
E
Y
D
E---
F
L
KLAHN
P
E
M
RF
V
FSN
T
TE
A
G
IS
Y
H
-
A
G
D
K
F
D
-
D
A
P
A
V
S
Y
--
-
--
--
P
A
KL
T
R
L
L
F
E
RF
SH
FNG
A
LD
K
G
WII
I
P
C
EL
I
DY
NG
DA
L
R
E
L
VL
R
Y
AQ
E
W
A
L
PE
AFI
Q
W
L
D
Q
A
N
SF
C
S
T
L
VDRIV
TGYP
R
D
E
V
A
KL
E
E
E
LG
Y
HD
GFLD
T
A
E
H
F
Y
LF
VI
QGPKSLATELRL
D
KY
-
-
---
-
-
-PL
N
V
L
I
V
D
D
I
K
PY
K
E
R
K
VAI
LNG
A
H
TA
L
VPVAFQ
A
G
LD
T
V
G
E
A
M
N
D
AEI
C
A
FV
EK
AI
Y
EE
II
P
V
L
D
LP
R
-
D
E
L
ES
F
A
SA
VT
G
RF
R
NP
Y
I
KHQ
LLS
IA
LN
G
MT
K
FRTRI
LPQ
-
LLAG
Q
K
-
--
A
NGT
L
P
AR
L
TFAL
A
ALIAF
YR
G
-
E
RN
G
ETYP
V
Q
D
D
A
HW
L
E
R
Y
QQL
W
S
Q
HR
DRVIG
TQ
E
L
V
A
IV
L
A
E
KDH
W
E
Q
DL
T
Q
V
P
G
L
V
E
Q
V
AN
D
L
DA
I
L
E
K
G
M
REAVR
P
LC
fig|478006.5.peg.1885
Escherichia coli O157:H7 str. EC4501
MKTLNRRDFPGAQ
Y
P
E
RI
IQ
FG
E
G
N
F
L
RA
FVDW
Q
I
D
L
L
N
E
H
TD
L
NS
G
VVV
V
R
P
IE
T
S
-
--
F
PPS
L
ST
Q
DG
LYT
T
I
IRGLN
EKG
E
AV
SDA
R
L
I
R
SV
N
REI
S
V
Y
S
E
Y
D
E---
F
L
KLAHN
P
E
M
RF
V
FSN
T
TE
A
G
IS
Y
H
-
A
G
D
K
F
D
-
D
A
P
A
V
S
Y
--
-
--
--
P
A
KL
T
R
L
L
F
E
RF
SH
FNG
A
LD
K
G
WII
I
P
C
EL
I
DY
NG
DA
L
R
E
L
VL
R
Y
AQ
E
W
A
L
PE
AFI
Q
W
L
D
Q
A
N
SF
C
S
T
L
VDRIV
TGYP
R
D
E
V
A
KL
E
E
E
LG
Y
HD
GFLD
T
A
E
H
F
Y
LF
VI
QGPKSLATELRL
D
KY
-
-
---
-
-
-PL
N
V
L
I
V
D
D
I
K
PY
K
E
R
K
VAI
LNG
A
H
TA
L
VPVAFQ
A
G
LD
T
V
G
E
A
M
N
D
AEI
C
A
FV
EK
AI
Y
EE
II
P
V
L
D
LP
R
-
D
E
L
ES
F
A
SA
VT
G
RF
R
NP
Y
I
KHQ
LLS
IA
LN
G
MT
K
FRTRI
LPQ
-
LLAG
Q
K
-
--
A
NGT
L
P
AR
L
TFAL
A
ALIAF
YR
G
-
E
RN
G
ETYP
V
Q
D
D
A
HW
L
E
R
Y
QQL
W
S
Q
HR
DRVIG
TQ
E
L
V
A
IV
L
A
E
KDH
W
E
Q
DL
T
Q
V
P
G
L
V
E
Q
V
AN
D
L
DA
I
L
E
K
G
M
REAVR
P
LC
fig|478007.5.peg.2089
Escherichia coli O157:H7 str. EC508
MKTLNRRDFPGAQ
Y
P
E
RI
IQ
FG
E
G
N
F
L
RA
FVDW
Q
I
D
L
L
N
E
H
TD
L
NS
G
VVV
V
R
P
IE
T
S
-
--
F
PPS
L
ST
Q
DG
LYT
T
I
IRGLN
EKG
E
AV
SDA
R
L
I
R
SV
N
REI
S
V
Y
S
E
Y
D
E---
F
L
KLAHN
P
E
M
RF
V
FSN
T
TE
A
G
IS
Y
H
-
A
G
D
K
F
D
-
D
A
P
A
V
S
Y
--
-
--
--
P
A
KL
T
R
L
L
F
E
RF
SH
FNG
A
LD
K
G
WII
I
P
C
EL
I
DY
NG
DA
L
R
E
L
VL
R
Y
AQ
E
W
A
L
PE
AFI
Q
W
L
D
Q
A
N
SF
C
S
T
L
VDRIV
TGYP
R
D
E
V
A
KL
E
E
E
LG
Y
HD
GFLD
T
A
E
H
F
Y
LF
VI
QGPKSLATELRL
D
KY
-
-
---
-
-
-PL
N
V
L
I
V
D
D
I
K
PY
K
E
R
K
VAI
LNG
A
H
TA
L
VPVAFQ
A
G
LD
T
V
G
E
A
M
N
D
AEI
C
A
FV
EK
AI
Y
EE
II
P
V
L
D
LP
R
-
D
E
L
ES
F
A
SA
VT
G
RF
R
NP
Y
I
KHQ
LLS
IA
LN
G
MT
K
FRTRI
LPQ
-
LLAG
Q
K
-
--
A
NGT
L
P
AR
L
TFAL
A
ALIAF
YR
G
-
E
RN
G
ETYP
V
Q
D
D
A
HW
L
E
R
Y
QQL
W
S
Q
HR
DRVIG
TQ
E
L
V
A
IV
L
A
E
KDH
W
E
Q
DL
T
Q
V
P
G
L
V
E
Q
V
AN
D
L
DA
I
L
E
K
G
M
REAVR
P
LC
fig|478008.5.peg.3609
Escherichia coli O157:H7 str. EC869
MKTLNRRDFPGAQ
Y
P
E
RI
IQ
FG
E
G
N
F
L
RA
FVDW
Q
I
D
L
L
N
E
H
TD
L
NS
G
VVV
V
R
P
IE
T
S
-
--
F
PPS
L
ST
Q
DG
LYT
T
I
IRGLN
EKG
E
AV
SDA
R
L
I
R
SV
N
REI
S
V
Y
S
E
Y
D
E---
F
L
KLAHN
P
E
M
RF
V
FSN
T
TE
A
G
IS
Y
H
-
A
G
D
K
F
D
-
D
A
P
A
V
S
Y
--
-
--
--
P
A
KL
T
R
L
L
F
E
RF
SH
FNG
A
LD
K
G
WII
I
P
C
EL
I
DY
NG
DA
L
R
E
L
VL
R
Y
AQ
E
W
A
L
PE
AFI
Q
W
L
D
Q
A
N
SF
C
S
T
L
VDRIV
TGYP
R
D
E
V
A
KL
E
E
E
LG
Y
HD
GFLD
T
A
E
H
F
Y
LF
VI
QGPKSLATELRL
D
KY
-
-
---
-
-
-PL
N
V
L
I
V
D
D
I
K
PY
K
E
R
K
VAI
LNG
A
H
TA
L
VPVAFQ
A
G
LD
T
V
G
E
A
M
N
D
AEI
C
A
FV
EK
AI
Y
EE
II
P
V
L
D
LP
R
-
D
E
L
ES
F
A
SA
VT
G
RF
R
NP
Y
I
KHQ
LLS
IA
LN
G
MT
K
FRTRI
LPQ
-
LLAG
Q
K
-
--
A
NGT
L
P
AR
L
TFAL
A
ALIAF
YR
G
-
E
RN
G
ETYP
V
Q
D
D
A
HW
L
E
R
Y
QQL
W
S
Q
HR
DRVIG
TQ
E
L
V
A
IV
L
A
E
KDH
W
E
Q
DL
T
Q
V
P
G
L
V
E
Q
V
AN
D
L
DA
I
L
E
K
G
M
REAVR
P
LC
fig|637388.3.peg.1596
Escherichia coli O157:H7 str. FRIK2000
MKTLNRRDFPGAQ
Y
P
E
RI
IQ
FG
E
G
N
F
L
RA
FVDW
Q
I
D
L
L
N
E
H
TD
L
NS
G
VVV
V
R
P
IE
T
S
-
--
F
PPS
L
ST
Q
DG
LYT
T
I
IRGLN
EKG
E
AV
SDA
R
L
I
R
SV
N
REI
S
V
Y
S
E
Y
D
E---
F
L
KLAHN
P
E
M
RF
V
FSN
T
TE
A
G
IS
Y
H
-
A
G
D
K
F
D
-
D
A
P
A
V
S
Y
--
-
--
--
P
A
KL
T
R
L
L
F
E
RF
SH
FNG
A
LD
K
G
WII
I
P
C
EL
I
DY
NG
DA
L
R
E
L
VL
R
Y
AQ
E
W
A
L
PE
AFI
Q
W
L
D
Q
A
N
SF
C
S
T
L
VDRIV
TGYP
R
D
E
V
A
KL
E
E
E
LG
Y
HD
GFLD
T
A
E
H
F
Y
LF
VI
QGPKSLATELRL
D
KY
-
-
---
-
-
-PL
N
V
L
I
V
D
D
I
K
PY
K
E
R
K
VAI
LNG
A
H
TA
L
VPVAFQ
A
G
LD
T
V
G
E
A
M
N
D
AEI
C
A
FV
EK
AI
Y
EE
II
P
V
L
D
LP
R
-
D
E
L
ES
F
A
SA
VT
G
RF
R
NP
Y
I
KHQ
LLS
IA
LN
G
MT
K
FRTRI
LPQ
-
LLAG
Q
K
-
--
A
NGT
L
P
AR
L
TFAL
A
ALIAF
YR
G
-
E
RN
G
ETYP
V
Q
D
D
A
HW
L
E
R
Y
QQL
W
S
Q
HR
DRVIG
TQ
E
L
V
A
IV
L
A
E
KDH
W
E
Q
DL
T
Q
V
P
G
L
V
E
Q
V
AN
D
L
DA
I
L
E
K
G
M
REAVR
P
LC
fig|570506.3.peg.2967
Escherichia coli O157:H7 str. FRIK966
MKTLNRRDFPGAQ
Y
P
E
RI
IQ
FG
E
G
N
F
L
RA
FVDW
Q
I
D
L
L
N
E
H
TD
L
NS
G
VVV
V
R
P
IE
T
S
-
--
F
PPS
L
ST
Q
DG
LYT
T
I
IRGLN
EKG
E
AV
SDA
R
L
I
R
SV
N
REI
S
V
Y
S
E
Y
D
E---
F
L
KLAHN
P
E
M
RF
V
FSN
T
TE
A
G
IS
Y
H
-
A
G
D
K
F
D
-
D
A
P
A
V
S
Y
--
-
--
--
P
A
KL
T
R
L
L
F
E
RF
SH
FNG
A
LD
K
G
WII
I
P
C
EL
I
DY
NG
DA
L
R
E
L
VL
R
Y
AQ
E
W
A
L
PE
AFI
Q
W
L
D
Q
A
N
SF
C
S
T
L
VDRIV
TGYP
R
D
E
V
A
KL
E
E
E
LG
Y
HD
GFLD
T
A
E
H
F
Y
LF
VI
QGPKSLATELRL
D
KY
-
-
---
-
-
-PL
N
V
L
I
V
D
D
I
K
PY
K
E
R
K
VAI
LNG
A
H
TA
L
VPVAFQ
A
G
LD
T
V
G
E
A
M
N
D
AEI
C
A
FV
EK
AI
Y
EE
II
P
V
L
D
LP
R
-
D
E
L
ES
F
A
SA
VT
G
RF
R
NP
Y
I
KHQ
LLS
IA
LN
G
MT
K
FRTRI
LPQ
-
LLAG
Q
K
-
--
A
NGT
L
P
AR
L
TFAL
A
ALIAF
YR
G
-
E
RN
G
ETYP
V
Q
D
D
A
HW
L
E
R
Y
QQL
W
S
Q
HR
DRVIG
TQ
E
L
V
A
IV
L
A
E
KDH
W
E
Q
DL
T
Q
V
P
G
L
V
E
Q
V
AN
D
L
DA
I
L
E
K
G
M
REAVR
P
LC
fig|386585.9.peg.2234
Escherichia coli O157:H7 str. Sakai
MKTLNRRDFPGAQ
Y
P
E
RI
IQ
FG
E
G
N
F
L
RA
FVDW
Q
I
D
L
L
N
E
H
TD
L
NS
G
VVV
V
R
P
IE
T
S
-
--
F
PPS
L
ST
Q
DG
LYT
T
I
IRGLN
EKG
E
AV
SDA
R
L
I
R
SV
N
REI
S
V
Y
S
E
Y
D
E---
F
L
KLAHN
P
E
M
RF
V
FSN
T
TE
A
G
IS
Y
H
-
A
G
D
K
F
D
-
D
A
P
A
V
S
Y
--
-
--
--
P
A
KL
T
R
L
L
F
E
RF
SH
FNG
A
LD
K
G
WII
I
P
C
EL
I
DY
NG
DA
L
R
E
L
VL
R
Y
AQ
E
W
A
L
PE
AFI
Q
W
L
D
Q
A
N
SF
C
S
T
L
VDRIV
TGYP
R
D
E
V
A
KL
E
E
E
LG
Y
HD
GFLD
T
A
E
H
F
Y
LF
VI
QGPKSLATELRL
D
KY
-
-
---
-
-
-PL
N
V
L
I
V
D
D
I
K
PY
K
E
R
K
VAI
LNG
A
H
TA
L
VPVAFQ
A
G
LD
T
V
G
E
A
M
N
D
AEI
C
A
FV
EK
AI
Y
EE
II
P
V
L
D
LP
R
-
D
E
L
ES
F
A
SA
VT
G
RF
R
NP
Y
I
KHQ
LLS
IA
LN
G
MT
K
FRTRI
LPQ
-
LLAG
Q
K
-
--
A
NGT
L
P
AR
L
TFAL
A
ALIAF
YR
G
-
E
RN
G
ETYP
V
Q
D
D
A
HW
L
E
R
Y
QQL
W
S
Q
HR
DRVIG
TQ
E
L
V
A
IV
L
A
E
KDH
W
E
Q
DL
T
Q
V
P
G
L
V
E
Q
V
AN
D
L
DA
I
L
E
K
G
M
REAVR
P
LC
fig|544404.4.peg.2043
Escherichia coli O157:H7 str. TW14359
MKTLNRRDFPGAQ
Y
P
E
RI
IQ
FG
E
G
N
F
L
RA
FVDW
Q
I
D
L
L
N
E
H
TD
L
NS
G
VVV
V
R
P
IE
T
S
-
--
F
PPS
L
ST
Q
DG
LYT
T
I
IRGLN
EKG
E
AV
SDA
R
L
I
R
SV
N
REI
S
V
Y
S
E
Y
D
E---
F
L
KLAHN
P
E
M
RF
V
FSN
T
TE
A
G
IS
Y
H
-
A
G
D
K
F
D
-
D
A
P
A
V
S
Y
--
-
--
--
P
A
KL
T
R
L
L
F
E
RF
SH
FNG
A
LD
K
G
WII
I
P
C
EL
I
DY
NG
DA
L
R
E
L
VL
R
Y
AQ
E
W
A
L
PE
AFI
Q
W
L
D
Q
A
N
SF
C
S
T
L
VDRIV
TGYP
R
D
E
V
A
KL
E
E
E
LG
Y
HD
GFLD
T
A
E
H
F
Y
LF
VI
QGPKSLATELRL
D
KY
-
-
---
-
-
-PL
N
V
L
I
V
D
D
I
K
PY
K
E
R
K
VAI
LNG
A
H
TA
L
VPVAFQ
A
G
LD
T
V
G
E
A
M
N
D
AEI
C
A
FV
EK
AI
Y
EE
II
P
V
L
D
LP
R
-
D
E
L
ES
F
A
SA
VT
G
RF
R
NP
Y
I
KHQ
LLS
IA
LN
G
MT
K
FRTRI
LPQ
-
LLAG
Q
K
-
--
A
NGT
L
P
AR
L
TFAL
A
ALIAF
YR
G
-
E
RN
G
ETYP
V
Q
D
D
A
HW
L
E
R
Y
QQL
W
S
Q
HR
DRVIG
TQ
E
L
V
A
IV
L
A
E
KDH
W
E
Q
DL
T
Q
V
P
G
L
V
E
Q
V
AN
D
L
DA
I
L
E
K
G
M
REAVR
P
LC
fig|502346.5.peg.5238
Escherichia coli O157:H7 str. TW14588
MKTLNRRDFPGAQ
Y
P
E
RI
IQ
FG
E
G
N
F
L
RA
FVDW
Q
I
D
L
L
N
E
H
TD
L
NS
G
VVV
V
R
P
IE
T
S
-
--
F
PPS
L
ST
Q
DG
LYT
T
I
IRGLN
EKG
E
AV
SDA
R
L
I
R
SV
N
REI
S
V
Y
S
E
Y
D
E---
F
L
KLAHN
P
E
M
RF
V
FSN
T
TE
A
G
IS
Y
H
-
A
G
D
K
F
D
-
D
A
P
A
V
S
Y
--
-
--
--
P
A
KL
T
R
L
L
F
E
RF
SH
FNG
A
LD
K
G
WII
I
P
C
EL
I
DY
NG
DA
L
R
E
L
VL
R
Y
AQ
E
W
A
L
PE
AFI
Q
W
L
D
Q
A
N
SF
C
S
T
L
VDRIV
TGYP
R
D
E
V
A
KL
E
E
E
LG
Y
HD
GFLD
T
A
E
H
F
Y
LF
VI
QGPKSLATELRL
D
KY
-
-
---
-
-
-PL
N
V
L
I
V
D
D
I
K
PY
K
E
R
K
VAI
LNG
A
H
TA
L
VPVAFQ
A
G
LD
T
V
G
E
A
M
N
D
AEI
C
A
FV
EK
AI
Y
EE
II
P
V
L
D
LP
R
-
D
E
L
ES
F
A
SA
VT
G
RF
R
NP
Y
I
KHQ
LLS
IA
LN
G
MT
K
FRTRI
LPQ
-
LLAG
Q
K
-
--
A
NGT
L
P
AR
L
TFAL
A
ALIAF
YR
G
-
E
RN
G
ETYP
V
Q
D
D
A
HW
L
E
R
Y
QQL
W
S
Q
HR
DRVIG
TQ
E
L
V
A
IV
L
A
E
KDH
W
E
Q
DL
T
Q
V
P
G
L
V
E
Q
V
AN
D
L
DA
I
L
E
K
G
M
REAVR
P
LC
fig|701177.3.peg.1878
Escherichia coli O55:H7 str. CB9615
MKTLNRRDFPGAQ
Y
P
E
RI
IQ
FG
E
G
N
F
L
RA
FVDW
Q
I
D
L
L
N
E
H
TD
L
NS
G
VVV
V
R
P
IE
T
S
-
--
F
PPS
L
ST
Q
DG
LYT
T
I
IRGLN
EKG
E
AV
SDA
R
L
I
R
SV
N
REI
S
V
Y
S
E
Y
D
E---
F
L
KLAHN
P
E
M
RF
V
FSN
T
TE
A
G
IS
Y
H
-
A
G
D
K
F
D
-
D
A
P
A
V
S
Y
--
-
--
--
P
A
KL
T
R
L
L
F
E
RF
SH
FNG
A
LD
K
G
WII
I
P
C
EL
I
DY
NG
DA
L
R
E
L
VL
R
Y
AQ
E
W
A
L
PE
AFI
Q
W
L
D
Q
A
N
SF
C
S
T
L
VDRIV
TGYP
R
D
E
V
A
KL
E
E
E
LG
Y
HD
GFLD
T
A
E
H
F
Y
LF
VI
QGPKSLATELRL
D
KY
-
-
---
-
-
-PL
N
V
L
I
V
D
D
I
K
PY
K
E
R
K
VAI
LNG
A
H
TA
L
VPVAFQ
A
G
LD
T
V
G
E
A
M
N
D
AEI
C
A
FV
EK
AI
Y
EE
II
P
V
L
D
LP
R
-
D
E
L
ES
F
A
SA
VT
G
RF
R
NP
Y
I
KHQ
LLS
IA
LN
G
MT
K
FRTRI
LPQ
-
LLAG
Q
K
-
--
A
NGT
L
P
AR
L
TFAL
A
ALIAF
YR
G
-
E
RN
G
ETYP
V
Q
D
D
A
HW
L
E
R
Y
QQL
W
S
Q
HR
DRVIG
TQ
E
L
V
A
IV
L
A
E
KDH
W
E
Q
DL
T
Q
V
P
G
L
V
E
Q
V
AN
D
L
DA
I
L
E
K
G
M
REAVR
P
LC
fig|439855.10.peg.1810
Escherichia coli SMS-3-5
MKTLNRRDFPGAQ
Y
P
E
RI
IQ
FG
E
G
N
F
L
RA
FVDW
Q
I
D
L
L
N
E
H
TD
L
NS
G
VVV
V
R
P
IE
T
S
-
--
F
PPS
L
ST
Q
DG
LYT
T
I
IRGLN
EKG
E
AV
SDA
R
L
I
R
SV
N
REI
S
V
Y
S
E
Y
D
E---
F
L
KLAHN
P
E
M
RF
V
FSN
T
TE
A
G
IS
Y
H
-
A
G
D
K
F
D
-
D
A
P
A
V
S
Y
--
-
--
--
P
A
KL
T
R
L
L
F
E
RF
SH
FNG
A
LD
K
G
WII
I
P
C
EL
I
DY
NG
DA
L
R
E
L
VL
R
Y
AQ
E
W
A
L
PE
AFI
Q
W
L
D
Q
A
N
SF
C
S
T
L
VDRIV
TGYP
R
D
E
V
A
KL
E
E
E
LG
Y
HD
GFLD
T
A
E
H
F
Y
LF
VI
QGPKSLATELRL
D
KY
-
-
---
-
-
-PL
N
V
L
I
V
D
D
I
K
PY
K
E
R
K
VAI
LNG
A
H
TA
L
VPVAFQ
A
G
LD
T
V
G
E
A
M
N
D
AEI
C
A
FV
EK
AI
Y
EE
II
P
V
L
D
LP
R
-
D
E
L
ES
F
A
SA
VT
G
RF
R
NP
Y
I
KHQ
LLS
IA
LN
G
MT
K
FRTRI
LPQ
-
LLAG
Q
K
-
--
A
NGT
L
P
AR
L
TFAL
A
ALIAF
YR
G
-
E
RN
G
ETYP
V
Q
D
D
A
HW
L
E
R
Y
QQL
W
S
Q
HR
DRVIG
TQ
E
L
V
A
IV
L
A
E
KDH
W
E
Q
DL
T
Q
V
P
G
L
V
E
Q
V
AN
D
L
DA
I
L
E
K
G
M
REAVR
P
LC
fig|656437.3.peg.1757
Escherichia coli TA143
MKTLNRRDFPGAQ
Y
P
E
RI
IQ
FG
E
G
N
F
L
RA
FVDW
Q
I
D
L
L
N
E
H
TD
L
NS
G
VVV
V
R
P
IE
T
S
-
--
F
PPS
L
ST
Q
DG
LYT
T
I
IRGLN
EKG
E
AV
SDA
R
L
I
R
SV
N
REI
S
V
Y
S
E
Y
D
E---
F
L
KLAHN
P
E
M
RF
V
FSN
T
TE
A
G
IS
Y
H
-
A
G
D
K
F
D
-
D
A
P
A
V
S
Y
--
-
--
--
P
A
KL
T
R
L
L
F
E
RF
SH
FNG
A
LD
K
G
WII
I
P
C
EL
I
DY
NG
DA
L
R
E
L
VL
R
Y
AQ
E
W
A
L
PE
AFI
Q
W
L
D
Q
A
N
SF
C
S
T
L
VDRIV
TGYP
R
D
E
V
A
KL
E
E
E
LG
Y
HD
GFLD
T
A
E
H
F
Y
LF
VI
QGPKSLATELRL
D
KY
-
-
---
-
-
-PL
N
V
L
I
V
D
D
I
K
PY
K
E
R
K
VAI
LNG
A
H
TA
L
VPVAFQ
A
G
LD
T
V
G
E
A
M
N
D
AEI
C
A
FV
EK
AI
Y
EE
II
P
V
L
D
LP
R
-
D
E
L
ES
F
A
SA
VT
G
RF
R
NP
Y
I
KHQ
LLS
IA
LN
G
MT
K
FRTRI
LPQ
-
LLAG
Q
K
-
--
A
NGT
L
P
AR
L
TFAL
A
ALIAF
YR
G
-
E
RN
G
ETYP
V
Q
D
D
A
HW
L
E
R
Y
QQL
W
S
Q
HR
DRVIG
TQ
E
L
V
A
IV
L
A
E
KDH
W
E
Q
DL
T
Q
V
P
G
L
V
E
Q
V
AN
D
L
DA
I
L
E
K
G
M
REAVR
P
LC
fig|656444.3.peg.2324
Escherichia coli TA280
MKTLNRRDFPGAQ
Y
P
E
RI
IQ
FG
E
G
N
F
L
RA
FVDW
Q
I
D
L
L
N
E
H
TD
L
NS
G
VVV
V
R
P
IE
T
S
-
--
F
PPS
L
ST
Q
DG
LYT
T
I
IRGLN
EKG
E
AV
SDA
R
L
I
R
SV
N
REI
S
V
Y
S
E
Y
D
E---
F
L
KLAHN
P
E
M
RF
V
FSN
T
TE
A
G
IS
Y
H
-
A
G
D
K
F
D
-
D
A
P
A
V
S
Y
--
-
--
--
P
A
KL
T
R
L
L
F
E
RF
SH
FNG
A
LD
K
G
WII
I
P
C
EL
I
DY
NG
DA
L
R
E
L
VL
R
Y
AQ
E
W
A
L
PE
AFI
Q
W
L
D
Q
A
N
SF
C
S
T
L
VDRIV
TGYP
R
D
E
V
A
KL
E
E
E
LG
Y
HD
GFLD
T
A
E
H
F
Y
LF
VI
QGPKSLATELRL
D
KY
-
-
---
-
-
-PL
N
V
L
I
V
D
D
I
K
PY
K
E
R
K
VAI
LNG
A
H
TA
L
VPVAFQ
A
G
LD
T
V
G
E
A
M
N
D
AEI
C
A
FV
EK
AI
Y
EE
II
P
V
L
D
LP
R
-
D
E
L
ES
F
A
SA
VT
G
RF
R
NP
Y
I
KHQ
LLS
IA
LN
G
MT
K
FRTRI
LPQ
-
LLAG
Q
K
-
--
A
NGT
L
P
AR
L
TFAL
A
ALIAF
YR
G
-
E
RN
G
ETYP
V
Q
D
D
A
HW
L
E
R
Y
QQL
W
S
Q
HR
DRVIG
TQ
E
L
V
A
IV
L
A
E
KDH
W
E
Q
DL
T
Q
V
P
G
L
V
E
Q
V
AN
D
L
DA
I
L
E
K
G
M
REAVR
P
LC
fig|316407.3.peg.1478
Escherichia coli W3110
MKTLNRRDFPGAQ
Y
P
E
RI
IQ
FG
E
G
N
F
L
RA
FVDW
Q
I
D
L
L
N
E
H
TD
L
NS
G
VVV
V
R
P
IE
T
S
-
--
F
PPS
L
ST
Q
DG
LYT
T
I
IRGLN
EKG
E
AV
SDA
R
L
I
R
SV
N
REI
S
V
Y
S
E
Y
D
E---
F
L
KLAHN
P
E
M
RF
V
FSN
T
TE
A
G
IS
Y
H
-
A
G
D
K
F
D
-
D
A
P
A
V
S
Y
--
-
--
--
P
A
KL
T
R
L
L
F
E
RF
SH
FNG
A
LD
K
G
WII
I
P
C
EL
I
DY
NG
DA
L
R
E
L
VL
R
Y
AQ
E
W
A
L
PE
AFI
Q
W
L
D
Q
A
N
SF
C
S
T
L
VDRIV
TGYP
R
D
E
V
A
KL
E
E
E
LG
Y
HD
GFLD
T
A
E
H
F
Y
LF
VI
QGPKSLATELRL
D
KY
-
-
---
-
-
-PL
N
V
L
I
V
D
D
I
K
PY
K
E
R
K
VAI
LNG
A
H
TA
L
VPVAFQ
A
G
LD
T
V
G
E
A
M
N
D
AEI
C
A
FV
EK
AI
Y
EE
II
P
V
L
D
LP
R
-
D
E
L
ES
F
A
SA
VT
G
RF
R
NP
Y
I
KHQ
LLS
IA
LN
G
MT
K
FRTRI
LPQ
-
LLAG
Q
K
-
--
A
NGT
L
P
AR
L
TFAL
A
ALIAF
YR
G
-
E
RN
G
ETYP
V
Q
D
D
A
HW
L
E
R
Y
QQL
W
S
Q
HR
DRVIG
TQ
E
L
V
A
IV
L
A
E
KDH
W
E
Q
DL
T
Q
V
P
G
L
V
E
Q
V
AN
D
L
DA
I
L
E
K
G
M
REAVR
P
LC
fig|511145.12.peg.1589
Escherichia coli str. K-12 substr. MG1655
MKTLNRRDFPGAQ
Y
P
E
RI
IQ
FG
E
G
N
F
L
RA
FVDW
Q
I
D
L
L
N
E
H
TD
L
NS
G
VVV
V
R
P
IE
T
S
-
--
F
PPS
L
ST
Q
DG
LYT
T
I
IRGLN
EKG
E
AV
SDA
R
L
I
R
SV
N
REI
S
V
Y
S
E
Y
D
E---
F
L
KLAHN
P
E
M
RF
V
FSN
T
TE
A
G
IS
Y
H
-
A
G
D
K
F
D
-
D
A
P
A
V
S
Y
--
-
--
--
P
A
KL
T
R
L
L
F
E
RF
SH
FNG
A
LD
K
G
WII
I
P
C
EL
I
DY
NG
DA
L
R
E
L
VL
R
Y
AQ
E
W
A
L
PE
AFI
Q
W
L
D
Q
A
N
SF
C
S
T
L
VDRIV
TGYP
R
D
E
V
A
KL
E
E
E
LG
Y
HD
GFLD
T
A
E
H
F
Y
LF
VI
QGPKSLATELRL
D
KY
-
-
---
-
-
-PL
N
V
L
I
V
D
D
I
K
PY
K
E
R
K
VAI
LNG
A
H
TA
L
VPVAFQ
A
G
LD
T
V
G
E
A
M
N
D
AEI
C
A
FV
EK
AI
Y
EE
II
P
V
L
D
LP
R
-
D
E
L
ES
F
A
SA
VT
G
RF
R
NP
Y
I
KHQ
LLS
IA
LN
G
MT
K
FRTRI
LPQ
-
LLAG
Q
K
-
--
A
NGT
L
P
AR
L
TFAL
A
ALIAF
YR
G
-
E
RN
G
ETYP
V
Q
D
D
A
HW
L
E
R
Y
QQL
W
S
Q
HR
DRVIG
TQ
E
L
V
A
IV
L
A
E
KDH
W
E
Q
DL
T
Q
V
P
G
L
V
E
Q
V
AN
D
L
DA
I
L
E
K
G
M
REAVR
P
LC
fig|511145.6.peg.1574
Escherichia coli str. K-12 substr. MG1655
MKTLNRRDFPGAQ
Y
P
E
RI
IQ
FG
E
G
N
F
L
RA
FVDW
Q
I
D
L
L
N
E
H
TD
L
NS
G
VVV
V
R
P
IE
T
S
-
--
F
PPS
L
ST
Q
DG
LYT
T
I
IRGLN
EKG
E
AV
SDA
R
L
I
R
SV
N
REI
S
V
Y
S
E
Y
D
E---
F
L
KLAHN
P
E
M
RF
V
FSN
T
TE
A
G
IS
Y
H
-
A
G
D
K
F
D
-
D
A
P
A
V
S
Y
--
-
--
--
P
A
KL
T
R
L
L
F
E
RF
SH
FNG
A
LD
K
G
WII
I
P
C
EL
I
DY
NG
DA
L
R
E
L
VL
R
Y
AQ
E
W
A
L
PE
AFI
Q
W
L
D
Q
A
N
SF
C
S
T
L
VDRIV
TGYP
R
D
E
V
A
KL
E
E
E
LG
Y
HD
GFLD
T
A
E
H
F
Y
LF
VI
QGPKSLATELRL
D
KY
-
-
---
-
-
-PL
N
V
L
I
V
D
D
I
K
PY
K
E
R
K
VAI
LNG
A
H
TA
L
VPVAFQ
A
G
LD
T
V
G
E
A
M
N
D
AEI
C
A
FV
EK
AI
Y
EE
II
P
V
L
D
LP
R
-
D
E
L
ES
F
A
SA
VT
G
RF
R
NP
Y
I
KHQ
LLS
IA
LN
G
MT
K
FRTRI
LPQ
-
LLAG
Q
K
-
--
A
NGT
L
P
AR
L
TFAL
A
ALIAF
YR
G
-
E
RN
G
ETYP
V
Q
D
D
A
HW
L
E
R
Y
QQL
W
S
Q
HR
DRVIG
TQ
E
L
V
A
IV
L
A
E
KDH
W
E
Q
DL
T
Q
V
P
G
L
V
E
Q
V
AN
D
L
DA
I
L
E
K
G
M
REAVR
P
LC
fig|679207.4.peg.4447
Escherichia coli MS 107-1
MKTLNRRDFPGAQ
Y
P
E
RI
IQ
FG
E
G
N
F
L
RA
FVDW
Q
I
D
L
L
N
E
H
TD
L
NS
G
VVV
V
R
P
IE
T
S
-
--
F
PPS
L
ST
Q
DG
LYT
T
I
IRGLN
EKG
E
AV
SDA
R
L
I
R
SV
N
REI
S
V
Y
S
E
Y
D
E---
F
L
KLAHN
P
E
M
RF
V
FSN
T
TE
A
G
IS
Y
H
-
A
G
D
K
F
D
-
D
A
P
A
V
S
Y
--
-
--
--
P
A
KL
T
R
L
L
F
E
RF
SH
FNG
A
LD
K
G
WII
I
P
C
EL
I
DY
NG
DA
L
R
E
L
VL
R
Y
AQ
E
W
A
L
PE
AFI
Q
W
L
D
Q
A
N
SF
C
S
T
L
VDRIV
TGYP
R
D
E
V
A
KL
E
E
E
LG
Y
HD
GFLD
T
A
E
H
F
Y
LF
VI
QGPKSLATELRL
D
KY
-
-
---
-
-
-PL
N
V
L
I
V
D
D
I
K
PY
K
E
R
K
VAI
LNG
A
H
TA
L
VPVAFQ
A
G
LD
T
V
G
E
A
M
N
D
AEI
C
A
FV
EK
AI
Y
EE
II
P
V
L
D
LP
R
-
D
E
L
ES
F
A
SA
VT
G
RF
R
NP
Y
I
KHQ
LLS
IA
LN
G
MT
K
FRTRI
LPQ
-
LLAG
Q
K
-
--
A
K
GT
L
P
AR
L
TFAL
A
ALIAF
YR
G
-
E
RN
G
ETYP
V
Q
D
D
A
HW
L
E
R
Y
QQL
W
S
Q
HR
DRVIG
TQ
E
L
V
A
IV
L
A
E
KDY
W
E
Q
DL
T
Q
V
P
G
L
V
E
Q
V
AN
D
L
DA
I
L
E
K
G
M
REAVR
P
LC
fig|344601.3.peg.294
Escherichia coli B171
MKTLNRRDFPGAQ
Y
P
E
RI
IQ
FG
E
G
N
F
L
RA
FVDW
Q
I
D
L
L
N
E
H
TD
L
NS
G
VVV
V
R
P
IE
T
S
-
--
F
PPS
L
ST
Q
DG
LYT
T
I
IRGLN
EKG
E
AV
SDA
R
L
I
R
T
V
N
REI
S
V
Y
S
E
Y
D
E---
F
L
KLAHN
P
E
M
RF
V
FSN
T
TE
A
G
IS
Y
H
-
A
G
D
K
F
D
-
D
A
P
A
V
S
Y
--
-
--
--
P
A
KL
T
R
L
L
F
E
RF
SH
FNG
A
LD
K
G
WII
I
P
C
EL
I
DY
NG
DA
L
R
E
L
VL
R
Y
AQ
E
W
A
L
PE
AFI
Q
W
L
D
Q
A
N
SF
C
S
T
L
VDRIV
TGYP
R
D
E
V
A
KL
E
E
E
LG
Y
HD
GFLD
T
A
E
H
F
Y
LF
VI
QGPKSLATELRL
D
KY
-
-
---
-
-
-PL
N
V
L
I
V
D
D
I
K
PY
K
E
R
K
VAI
LNG
A
H
TA
L
VPVAFQ
A
G
LD
T
V
G
E
A
M
N
D
AEI
C
A
FV
EK
AI
Y
EE
II
P
V
L
D
LP
R
-
D
E
L
ES
F
A
SA
VT
G
RF
R
NP
Y
I
KHQ
LLS
IA
LN
G
MT
K
FRTRI
LPQ
-
LLAG
Q
K
-
--
A
NGT
L
P
AR
L
TFAL
A
ALIAF
YR
G
-
E
RN
G
ETYP
V
Q
D
D
A
HW
L
E
R
Y
QQL
W
S
Q
HR
DRVIG
TQ
E
L
V
A
IV
L
A
E
KDH
W
E
Q
DL
T
Q
V
P
G
L
V
E
Q
V
AN
D
L
DA
I
L
E
K
G
M
REAVR
P
LC
fig|344601.5.peg.290
Escherichia coli B171
MKTLNRRDFPGAQ
Y
P
E
RI
IQ
FG
E
G
N
F
L
RA
FVDW
Q
I
D
L
L
N
E
H
TD
L
NS
G
VVV
V
R
P
IE
T
S
-
--
F
PPS
L
ST
Q
DG
LYT
T
I
IRGLN
EKG
E
AV
SDA
R
L
I
R
T
V
N
REI
S
V
Y
S
E
Y
D
E---
F
L
KLAHN
P
E
M
RF
V
FSN
T
TE
A
G
IS
Y
H
-
A
G
D
K
F
D
-
D
A
P
A
V
S
Y
--
-
--
--
P
A
KL
T
R
L
L
F
E
RF
SH
FNG
A
LD
K
G
WII
I
P
C
EL
I
DY
NG
DA
L
R
E
L
VL
R
Y
AQ
E
W
A
L
PE
AFI
Q
W
L
D
Q
A
N
SF
C
S
T
L
VDRIV
TGYP
R
D
E
V
A
KL
E
E
E
LG
Y
HD
GFLD
T
A
E
H
F
Y
LF
VI
QGPKSLATELRL
D
KY
-
-
---
-
-
-PL
N
V
L
I
V
D
D
I
K
PY
K
E
R
K
VAI
LNG
A
H
TA
L
VPVAFQ
A
G
LD
T
V
G
E
A
M
N
D
AEI
C
A
FV
EK
AI
Y
EE
II
P
V
L
D
LP
R
-
D
E
L
ES
F
A
SA
VT
G
RF
R
NP
Y
I
KHQ
LLS
IA
LN
G
MT
K
FRTRI
LPQ
-
LLAG
Q
K
-
--
A
NGT
L
P
AR
L
TFAL
A
ALIAF
YR
G
-
E
RN
G
ETYP
V
Q
D
D
A
HW
L
E
R
Y
QQL
W
S
Q
HR
DRVIG
TQ
E
L
V
A
IV
L
A
E
KDH
W
E
Q
DL
T
Q
V
P
G
L
V
E
Q
V
AN
D
L
DA
I
L
E
K
G
M
REAVR
P
LC
fig|573235.3.peg.2156
Escherichia coli O26:H11 str. 11368
MKTLNRRDFPGAQ
Y
P
E
RI
IQ
FG
E
G
N
F
L
RA
FVDW
Q
I
D
L
L
N
E
H
TD
L
NS
G
VVV
V
R
P
IE
T
S
-
--
F
PPS
L
ST
Q
DG
LYT
T
I
IRGLN
EKG
E
AV
SDA
R
L
I
R
SV
N
REI
S
V
Y
S
E
Y
D
E---
F
L
KLAHN
P
E
M
RF
V
FSN
T
TE
A
G
IS
Y
H
-
A
G
D
K
F
D
-
D
A
P
A
V
S
Y
--
-
--
--
P
A
KL
T
R
L
L
F
E
RF
SH
FNG
A
LD
K
G
WII
I
P
C
EL
I
DY
NG
DA
L
R
E
L
VL
R
Y
AQ
E
W
A
L
PE
AFI
Q
W
L
D
Q
A
N
SF
C
S
T
L
VDRIV
TGYP
R
D
E
V
A
KL
E
E
E
LG
Y
HD
GFLD
T
A
E
H
F
Y
LF
VI
QGPKSLATELRL
D
KY
-
-
---
-
-
-PL
N
V
L
I
V
D
D
I
K
PY
K
E
R
K
VAI
LNG
A
H
TA
L
VPVAFQ
A
G
LD
T
V
G
E
A
M
N
D
AEI
C
A
FV
EK
AI
Y
EE
II
P
V
L
D
LP
R
-
D
E
L
ES
F
A
SA
VT
G
RF
R
NP
Y
I
KHQ
LLS
IA
LN
G
MT
K
FRTRI
LPQ
-
LLA
R
Q
K
-
--
A
K
GT
L
P
AR
L
TFAL
A
ALIAF
YR
G
-
E
RN
G
ETYP
V
Q
D
D
A
HW
L
E
R
Y
QQL
W
S
Q
HR
DRVIG
TQ
E
L
V
A
IV
L
A
E
KDH
W
E
Q
DL
T
Q
V
P
G
L
V
E
Q
V
AN
D
L
DA
I
L
E
K
G
M
REAVR
P
LC
fig|656379.3.peg.3576
Escherichia coli FVEC1302
MKTLNRRDFPGAQ
Y
P
E
RI
IQ
FG
E
G
N
F
L
RA
FVDW
Q
I
D
L
L
N
E
H
TD
L
NS
G
VVV
V
R
P
IE
T
S
-
--
F
PPS
L
ST
Q
DG
LYT
T
I
IRGLN
EKG
E
AV
SDA
R
L
I
R
SV
N
REI
S
V
Y
S
E
Y
D
E---
F
L
KLAHN
P
E
M
RF
V
FSN
T
TE
A
G
IS
Y
H
-
A
G
D
K
F
D
-
D
A
P
A
V
S
Y
--
-
--
--
P
A
KL
T
R
L
L
F
E
RF
SH
FNG
A
LD
K
G
WII
I
P
C
EL
I
DY
NG
DA
L
R
E
L
VL
R
Y
AQ
E
W
A
L
PE
AFI
Q
W
L
D
Q
A
N
SF
C
S
T
L
VDRIV
TGYP
R
D
E
V
A
KL
E
E
E
LG
Y
HD
GFLD
T
A
E
H
F
Y
LF
VI
QGPKSLATELRL
D
KY
-
-
---
-
-
-PL
N
V
L
I
V
D
D
I
K
PY
K
E
R
K
VAI
LNG
A
H
TA
L
VPVAFQ
A
G
LD
T
V
G
E
A
M
N
D
AEI
C
A
FV
EK
AI
Y
EE
II
P
V
L
D
LP
R
-
D
E
L
ES
F
A
SA
VT
G
RF
R
NP
Y
I
KHQ
LLS
IA
LN
G
MT
K
FRTRI
LPQ
-
LLAG
Q
K
-
--
A
NGT
L
P
AR
L
TFAL
A
ALIAF
YR
G
-
E
RN
G
ETYP
V
Q
D
D
A
HW
L
E
R
Y
QQL
W
S
Q
HR
DRVIG
TQ
E
L
V
A
IV
L
A
E
KDH
W
E
Q
DL
T
Q
V
P
G
L
V
E
Q
V
AN
D
L
D
V
I
L
E
K
G
M
REAVR
P
LC
fig|656380.3.peg.2926
Escherichia coli FVEC1412
MKTLNRRDFPGAQ
Y
P
E
RI
IQ
FG
E
G
N
F
L
RA
FVDW
Q
I
D
L
L
N
E
H
TD
L
NS
G
VVV
V
R
P
IE
T
S
-
--
F
PPS
L
ST
Q
DG
LYT
T
I
IRGLN
EKG
E
AV
SDA
R
L
I
R
SV
N
REI
S
V
Y
S
E
Y
D
E---
F
L
KLAHN
P
E
M
RF
V
FSN
T
TE
A
G
IS
Y
H
-
A
G
D
K
F
D
-
D
A
P
A
V
S
Y
--
-
--
--
P
A
KL
T
R
L
L
F
E
RF
SH
FNG
A
LD
K
G
WII
I
P
C
EL
I
DY
NG
DA
L
R
E
L
VL
R
Y
AQ
E
W
A
L
PE
AFI
Q
W
L
D
Q
A
N
SF
C
S
T
L
VDRIV
TGYP
R
D
E
V
A
KL
E
E
E
LG
Y
HD
GFLD
T
A
E
H
F
Y
LF
VI
QGPKSLATELRL
D
KY
-
-
---
-
-
-PL
N
V
L
I
V
D
D
I
K
PY
K
E
R
K
VAI
LNG
A
H
TA
L
VPVAFQ
A
G
LD
T
V
G
E
A
M
N
D
AEI
C
A
FV
EK
AI
Y
EE
II
P
V
L
D
LP
R
-
D
E
L
ES
F
A
SA
VT
G
RF
R
NP
Y
I
KHQ
LLS
IA
LN
G
MT
K
FRTRI
LPQ
-
LLAG
Q
K
-
--
A
NGT
L
P
AR
L
TFAL
A
ALIAF
YR
G
-
E
RN
G
ETYP
V
Q
D
D
A
HW
L
E
R
Y
QQL
W
S
Q
HR
DRVIG
TQ
E
L
V
A
IV
L
A
E
KDH
W
E
Q
DL
T
Q
V
P
G
L
V
E
Q
V
AN
D
L
D
V
I
L
E
K
G
M
REAVR
P
LC
fig|749549.3.peg.1897
Escherichia coli MS 198-1
MKTLNRRDFPGAQ
Y
P
E
RI
IQ
FG
E
G
N
F
L
RA
FVDW
Q
I
D
L
L
N
E
H
TD
L
NS
G
VVV
V
R
P
IE
T
S
-
--
F
PPS
L
ST
Q
DG
LYT
T
I
IRGLN
EKG
E
AV
SDA
R
L
I
R
SV
N
REI
S
V
Y
S
E
Y
D
E---
F
L
KLAHN
P
E
M
RF
V
FSN
T
TE
A
G
IS
Y
H
-
A
G
D
K
F
D
-
D
A
P
A
V
S
Y
--
-
--
--
P
A
KL
T
R
L
L
F
E
RF
SH
FNG
A
LD
K
G
WII
I
P
C
EL
I
DY
NG
DA
L
R
E
L
VL
R
Y
AQ
E
W
A
L
PE
AFI
Q
W
L
D
Q
A
N
SF
C
S
T
L
VDRIV
TGYP
R
D
E
V
A
KL
E
E
E
LG
Y
HD
GFLD
T
A
E
H
F
Y
LF
VI
QGPKSLATELRL
D
KY
-
-
---
-
-
-PL
N
V
L
I
V
D
D
I
K
PY
K
E
R
K
VAI
LNG
A
H
TA
L
VPVAFQ
A
G
LD
T
V
G
E
A
M
N
D
AEI
C
A
FV
EK
AI
Y
EE
II
P
V
L
D
LP
R
-
D
E
L
ES
F
A
SA
VT
G
RF
R
NP
Y
I
KHQ
LLS
IA
LN
G
MT
K
FRTRI
LPQ
-
LLAG
Q
K
-
--
A
NGT
L
P
AR
L
TFAL
A
ALIAF
YR
G
-
E
RN
G
ETYP
V
Q
D
D
A
HW
L
E
R
Y
QQL
W
S
Q
HR
DRVIG
TQ
E
L
V
A
IV
L
A
E
KDH
W
E
Q
DL
T
Q
V
P
G
L
V
E
Q
V
AN
D
L
D
V
I
L
E
K
G
M
REAVR
P
LC
fig|585056.7.peg.1975
Escherichia coli UMN026
MKTLNRRDFPGAQ
Y
P
E
RI
IQ
FG
E
G
N
F
L
RA
FVDW
Q
I
D
L
L
N
E
H
TD
L
NS
G
VVV
V
R
P
IE
T
S
-
--
F
PPS
L
ST
Q
DG
LYT
T
I
IRGLN
EKG
E
AV
SDA
R
L
I
R
SV
N
REI
S
V
Y
S
E
Y
D
E---
F
L
KLAHN
P
E
M
RF
V
FSN
T
TE
A
G
IS
Y
H
-
A
G
D
K
F
D
-
D
A
P
A
V
S
Y
--
-
--
--
P
A
KL
T
R
L
L
F
E
RF
SH
FNG
A
LD
K
G
WII
I
P
C
EL
I
DY
NG
DA
L
R
E
L
VL
R
Y
AQ
E
W
A
L
PE
AFI
Q
W
L
D
Q
A
N
SF
C
S
T
L
VDRIV
TGYP
R
D
E
V
A
KL
E
E
E
LG
Y
HD
GFLD
T
A
E
H
F
Y
LF
VI
QGPKSLATELRL
D
KY
-
-
---
-
-
-PL
N
V
L
I
V
D
D
I
K
PY
K
E
R
K
VAI
LNG
A
H
TA
L
VPVAFQ
A
G
LD
T
V
G
E
A
M
N
D
AEI
C
A
FV
EK
AI
Y
EE
II
P
V
L
D
LP
R
-
D
E
L
ES
F
A
SA
VT
G
RF
R
NP
Y
I
KHQ
LLS
IA
LN
G
MT
K
FRTRI
LPQ
-
LLAG
Q
K
-
--
A
NGT
L
P
AR
L
TFAL
A
ALIAF
YR
G
-
E
RN
G
ETYP
V
Q
D
D
A
HW
L
E
R
Y
QQL
W
S
Q
HR
DRVIG
TQ
E
L
V
A
IV
L
A
E
KDH
W
E
Q
DL
T
Q
V
P
G
L
V
E
Q
V
AN
D
L
D
V
I
L
E
K
G
M
REAVR
P
LC
fig|585396.4.peg.1995
Escherichia coli O111:H- str. 11128
MKTLNRRDFPGAQ
Y
P
E
RI
IQ
FG
E
G
N
F
L
RA
FVDW
Q
I
D
L
L
N
E
H
TD
L
NS
G
VVV
V
R
P
IE
T
S
-
--
F
PPS
L
ST
Q
DG
LYT
T
I
IRGLN
EKG
E
AV
SDA
R
L
I
R
SV
N
REI
S
V
Y
S
E
Y
D
E---
F
L
KLAHN
P
E
M
RF
V
FSN
T
TE
A
G
IS
Y
H
-
A
G
D
K
F
D
-
D
A
P
A
V
S
Y
--
-
--
--
P
A
KL
T
R
L
L
F
E
RF
SH
FNG
A
LD
K
G
WII
I
P
C
EL
I
DY
NG
DA
L
R
E
L
VL
R
Y
AQ
E
W
A
L
PE
AFI
Q
W
L
D
Q
A
N
SF
C
S
T
L
VDRIV
TGYP
C
D
E
V
A
KL
E
E
E
LG
Y
HD
GFLD
T
A
E
H
F
Y
LF
VI
QGPKSLATELRL
D
KY
-
-
---
-
-
-PL
N
V
L
I
V
D
D
I
K
PY
K
E
R
K
VAI
LNG
A
H
TA
L
VPVAFQ
A
G
LD
T
V
G
E
A
M
N
D
AEI
C
A
FV
EK
AI
Y
EE
II
P
V
L
D
LP
R
-
D
E
L
ES
F
A
SA
VT
G
RF
R
NP
Y
I
KHQ
LLS
IA
LN
G
MT
K
FRTRI
LPQ
-
LLAG
Q
K
-
--
A
K
GT
L
P
AR
L
TFAL
A
ALIAF
YR
G
-
E
RN
G
ETYP
V
Q
D
D
A
HW
L
E
R
Y
QQL
W
S
Q
HR
DRVIG
TQ
E
L
V
A
IV
L
A
E
KDH
W
E
Q
DL
T
Q
V
P
G
L
V
E
Q
V
AN
D
L
DA
I
L
E
K
G
M
REAVR
P
LC
fig|670897.3.peg.2367
Escherichia coli 2362-75
MKTLNRRDFPGAQ
Y
P
E
RI
IQ
FG
E
G
N
F
L
RA
FVDW
Q
I
D
L
L
N
E
H
TD
L
NS
G
VVV
V
R
P
IE
T
S
-
--
F
PPS
L
ST
Q
DG
LYT
T
I
IRGLN
EKG
E
AV
SDA
R
L
I
R
SV
N
REI
S
V
Y
S
E
Y
D
E---
F
L
KLAHN
P
E
M
RF
V
FSN
T
TE
A
G
IS
Y
H
-
A
G
D
K
F
D
-
D
A
P
A
V
S
Y
--
-
--
--
P
A
KL
T
R
L
L
F
E
RF
SH
FNG
A
LD
K
G
WII
I
P
C
EL
I
DY
NG
DA
L
R
E
L
VL
R
Y
AQ
E
W
A
L
PE
AFI
Q
W
L
D
Q
A
N
SF
C
S
T
L
VDRIV
TGYP
R
D
E
V
A
KL
E
E
E
LG
Y
HD
GFLD
T
A
E
H
F
Y
LF
VI
QGPKSLATELRL
D
KY
-
-
---
-
-
-PL
N
V
L
I
V
D
D
I
K
PY
K
E
R
K
VAI
LNG
A
H
TA
L
VPVAFQ
A
G
LD
T
V
G
E
A
M
N
D
AEI
C
A
FV
EK
AI
Y
EE
II
P
V
L
D
LP
R
-
D
E
L
ES
F
A
SA
VT
G
RF
R
NP
Y
I
KHQ
LLS
IA
LN
G
MT
K
FRTRI
LPQ
-
LLAG
Q
K
-
--
A
NGT
L
P
AR
L
TFAL
A
ALIAF
YR
G
-
E
RN
G
ETYP
V
Q
D
D
A
HW
L
E
R
Y
QQL
W
S
Q
YR
DRVIG
TQ
E
L
V
A
IV
L
A
E
KDH
W
E
Q
DL
T
Q
V
P
G
L
V
E
Q
V
AN
D
L
DA
I
L
E
K
G
M
REAVR
P
LC
fig|405955.13.peg.1634
Escherichia coli APEC O1
MKTLNRRDFPGAQ
Y
P
E
RI
IQ
FG
E
G
N
F
L
RA
FVDW
Q
I
D
L
L
N
E
H
TD
L
NS
G
VVV
V
R
P
IE
T
S
-
--
F
PPS
L
ST
Q
DG
LYT
T
I
IRGLN
EKG
E
AV
SDA
R
L
I
R
SV
N
REI
S
V
Y
S
E
Y
D
E---
F
L
KLAHN
P
E
M
RF
V
FSN
T
TE
A
G
IS
Y
H
-
A
G
D
K
F
D
-
D
A
P
A
V
S
Y
--
-
--
--
P
A
KL
T
R
L
L
F
E
RF
SH
FNG
A
LD
K
G
WII
I
P
C
EL
I
DY
NG
DA
L
R
E
L
VL
R
Y
AQ
E
W
A
L
PE
AFI
Q
W
L
D
Q
A
N
SF
C
S
T
L
VDRIV
TGYP
R
D
E
V
A
KL
E
E
E
LG
Y
HD
GFLD
T
A
E
H
F
Y
LF
VI
QGPKSLATELRL
D
KY
-
-
---
-
-
-PL
N
V
L
I
V
D
D
I
K
PY
K
E
R
K
VAI
LNG
A
H
TA
L
VPVAFQ
A
G
LD
T
V
G
E
A
M
N
D
AEI
C
A
FV
EK
AI
Y
EE
II
P
V
L
D
LP
R
-
D
E
L
ES
F
A
SA
VT
G
RF
R
NP
Y
I
KHQ
LLS
IA
LN
G
MT
K
FRTRI
LPQ
-
LLAG
Q
K
-
--
A
NGT
L
P
AR
L
TFAL
A
ALIAF
YR
G
-
E
RN
G
ETYP
V
Q
D
D
A
HW
L
E
R
Y
QQL
W
S
Q
YR
DRVIG
TQ
E
L
V
A
IV
L
A
E
KDH
W
E
Q
DL
T
Q
V
P
G
L
V
E
Q
V
AN
D
L
DA
I
L
E
K
G
M
REAVR
P
LC
fig|405955.9.peg.1326
Escherichia coli APEC O1
MKTLNRRDFPGAQ
Y
P
E
RI
IQ
FG
E
G
N
F
L
RA
FVDW
Q
I
D
L
L
N
E
H
TD
L
NS
G
VVV
V
R
P
IE
T
S
-
--
F
PPS
L
ST
Q
DG
LYT
T
I
IRGLN
EKG
E
AV
SDA
R
L
I
R
SV
N
REI
S
V
Y
S
E
Y
D
E---
F
L
KLAHN
P
E
M
RF
V
FSN
T
TE
A
G
IS
Y
H
-
A
G
D
K
F
D
-
D
A
P
A
V
S
Y
--
-
--
--
P
A
KL
T
R
L
L
F
E
RF
SH
FNG
A
LD
K
G
WII
I
P
C
EL
I
DY
NG
DA
L
R
E
L
VL
R
Y
AQ
E
W
A
L
PE
AFI
Q
W
L
D
Q
A
N
SF
C
S
T
L
VDRIV
TGYP
R
D
E
V
A
KL
E
E
E
LG
Y
HD
GFLD
T
A
E
H
F
Y
LF
VI
QGPKSLATELRL
D
KY
-
-
---
-
-
-PL
N
V
L
I
V
D
D
I
K
PY
K
E
R
K
VAI
LNG
A
H
TA
L
VPVAFQ
A
G
LD
T
V
G
E
A
M
N
D
AEI
C
A
FV
EK
AI
Y
EE
II
P
V
L
D
LP
R
-
D
E
L
ES
F
A
SA
VT
G
RF
R
NP
Y
I
KHQ
LLS
IA
LN
G
MT
K
FRTRI
LPQ
-
LLAG
Q
K
-
--
A
NGT
L
P
AR
L
TFAL
A
ALIAF
YR
G
-
E
RN
G
ETYP
V
Q
D
D
A
HW
L
E
R
Y
QQL
W
S
Q
YR
DRVIG
TQ
E
L
V
A
IV
L
A
E
KDH
W
E
Q
DL
T
Q
V
P
G
L
V
E
Q
V
AN
D
L
DA
I
L
E
K
G
M
REAVR
P
LC
fig|216593.1.peg.325
Escherichia coli E2348/69
MKTLNRRDFPGAQ
Y
P
E
RI
IQ
FG
E
G
N
F
L
RA
FVDW
Q
I
D
L
L
N
E
H
TD
L
NS
G
VVV
V
R
P
IE
T
S
-
--
F
PPS
L
ST
Q
DG
LYT
T
I
IRGLN
EKG
E
AV
SDA
R
L
I
R
SV
N
REI
S
V
Y
S
E
Y
D
E---
F
L
KLAHN
P
E
M
RF
V
FSN
T
TE
A
G
IS
Y
H
-
A
G
D
K
F
D
-
D
A
P
A
V
S
Y
--
-
--
--
P
A
KL
T
R
L
L
F
E
RF
SH
FNG
A
LD
K
G
WII
I
P
C
EL
I
DY
NG
DA
L
R
E
L
VL
R
Y
AQ
E
W
A
L
PE
AFI
Q
W
L
D
Q
A
N
SF
C
S
T
L
VDRIV
TGYP
R
D
E
V
A
KL
E
E
E
LG
Y
HD
GFLD
T
A
E
H
F
Y
LF
VI
QGPKSLATELRL
D
KY
-
-
---
-
-
-PL
N
V
L
I
V
D
D
I
K
PY
K
E
R
K
VAI
LNG
A
H
TA
L
VPVAFQ
A
G
LD
T
V
G
E
A
M
N
D
AEI
C
A
FV
EK
AI
Y
EE
II
P
V
L
D
LP
R
-
D
E
L
ES
F
A
SA
VT
G
RF
R
NP
Y
I
KHQ
LLS
IA
LN
G
MT
K
FRTRI
LPQ
-
LLAG
Q
K
-
--
A
NGT
L
P
AR
L
TFAL
A
ALIAF
YR
G
-
E
RN
G
ETYP
V
Q
D
D
A
HW
L
E
R
Y
QQL
W
S
Q
YR
DRVIG
TQ
E
L
V
A
IV
L
A
E
KDH
W
E
Q
DL
T
Q
V
P
G
L
V
E
Q
V
AN
D
L
DA
I
L
E
K
G
M
REAVR
P
LC
fig|714962.3.peg.1700
Escherichia coli IHE3034
MKTLNRRDFPGAQ
Y
P
E
RI
IQ
FG
E
G
N
F
L
RA
FVDW
Q
I
D
L
L
N
E
H
TD
L
NS
G
VVV
V
R
P
IE
T
S
-
--
F
PPS
L
ST
Q
DG
LYT
T
I
IRGLN
EKG
E
AV
SDA
R
L
I
R
SV
N
REI
S
V
Y
S
E
Y
D
E---
F
L
KLAHN
P
E
M
RF
V
FSN
T
TE
A
G
IS
Y
H
-
A
G
D
K
F
D
-
D
A
P
A
V
S
Y
--
-
--
--
P
A
KL
T
R
L
L
F
E
RF
SH
FNG
A
LD
K
G
WII
I
P
C
EL
I
DY
NG
DA
L
R
E
L
VL
R
Y
AQ
E
W
A
L
PE
AFI
Q
W
L
D
Q
A
N
SF
C
S
T
L
VDRIV
TGYP
R
D
E
V
A
KL
E
E
E
LG
Y
HD
GFLD
T
A
E
H
F
Y
LF
VI
QGPKSLATELRL
D
KY
-
-
---
-
-
-PL
N
V
L
I
V
D
D
I
K
PY
K
E
R
K
VAI
LNG
A
H
TA
L
VPVAFQ
A
G
LD
T
V
G
E
A
M
N
D
AEI
C
A
FV
EK
AI
Y
EE
II
P
V
L
D
LP
R
-
D
E
L
ES
F
A
SA
VT
G
RF
R
NP
Y
I
KHQ
LLS
IA
LN
G
MT
K
FRTRI
LPQ
-
LLAG
Q
K
-
--
A
NGT
L
P
AR
L
TFAL
A
ALIAF
YR
G
-
E
RN
G
ETYP
V
Q
D
D
A
HW
L
E
R
Y
QQL
W
S
Q
YR
DRVIG
TQ
E
L
V
A
IV
L
A
E
KDH
W
E
Q
DL
T
Q
V
P
G
L
V
E
Q
V
AN
D
L
DA
I
L
E
K
G
M
REAVR
P
LC
fig|656417.3.peg.2045
Escherichia coli M605
MKTLNRRDFPGAQ
Y
P
E
RI
IQ
FG
E
G
N
F
L
RA
FVDW
Q
I
D
L
L
N
E
H
TD
L
NS
G
VVV
V
R
P
IE
T
S
-
--
F
PPS
L
ST
Q
DG
LYT
T
I
IRGLN
EKG
E
AV
SDA
R
L
I
R
SV
N
REI
S
V
Y
S
E
Y
D
E---
F
L
KLAHN
P
E
M
RF
V
FSN
T
TE
A
G
IS
Y
H
-
A
G
D
K
F
D
-
D
A
P
A
V
S
Y
--
-
--
--
P
A
KL
T
R
L
L
F
E
RF
SH
FNG
A
LD
K
G
WII
I
P
C
EL
I
DY
NG
DA
L
R
E
L
VL
R
Y
AQ
E
W
A
L
PE
AFI
Q
W
L
D
Q
A
N
SF
C
S
T
L
VDRIV
TGYP
R
D
E
V
A
KL
E
E
E
LG
Y
HD
GFLD
T
A
E
H
F
Y
LF
VI
QGPKSLATELRL
D
KY
-
-
---
-
-
-PL
N
V
L
I
V
D
D
I
K
PY
K
E
R
K
VAI
LNG
A
H
TA
L
VPVAFQ
A
G
LD
T
V
G
E
A
M
N
D
AEI
C
A
FV
EK
AI
Y
EE
II
P
V
L
D
LP
R
-
D
E
L
ES
F
A
SA
VT
G
RF
R
NP
Y
I
KHQ
LLS
IA
LN
G
MT
K
FRTRI
LPQ
-
LLAG
Q
K
-
--
A
NGT
L
P
AR
L
TFAL
A
ALIAF
YR
G
-
E
RN
G
ETYP
V
Q
D
D
A
HW
L
E
R
Y
QQL
W
S
Q
YR
DRVIG
TQ
E
L
V
A
IV
L
A
E
KDH
W
E
Q
DL
T
Q
V
P
G
L
V
E
Q
V
AN
D
L
DA
I
L
E
K
G
M
REAVR
P
LC
fig|574521.7.peg.1677
Escherichia coli O127:H6 str. E2348/69
MKTLNRRDFPGAQ
Y
P
E
RI
IQ
FG
E
G
N
F
L
RA
FVDW
Q
I
D
L
L
N
E
H
TD
L
NS
G
VVV
V
R
P
IE
T
S
-
--
F
PPS
L
ST
Q
DG
LYT
T
I
IRGLN
EKG
E
AV
SDA
R
L
I
R
SV
N
REI
S
V
Y
S
E
Y
D
E---
F
L
KLAHN
P
E
M
RF
V
FSN
T
TE
A
G
IS
Y
H
-
A
G
D
K
F
D
-
D
A
P
A
V
S
Y
--
-
--
--
P
A
KL
T
R
L
L
F
E
RF
SH
FNG
A
LD
K
G
WII
I
P
C
EL
I
DY
NG
DA
L
R
E
L
VL
R
Y
AQ
E
W
A
L
PE
AFI
Q
W
L
D
Q
A
N
SF
C
S
T
L
VDRIV
TGYP
R
D
E
V
A
KL
E
E
E
LG
Y
HD
GFLD
T
A
E
H
F
Y
LF
VI
QGPKSLATELRL
D
KY
-
-
---
-
-
-PL
N
V
L
I
V
D
D
I
K
PY
K
E
R
K
VAI
LNG
A
H
TA
L
VPVAFQ
A
G
LD
T
V
G
E
A
M
N
D
AEI
C
A
FV
EK
AI
Y
EE
II
P
V
L
D
LP
R
-
D
E
L
ES
F
A
SA
VT
G
RF
R
NP
Y
I
KHQ
LLS
IA
LN
G
MT
K
FRTRI
LPQ
-
LLAG
Q
K
-
--
A
NGT
L
P
AR
L
TFAL
A
ALIAF
YR
G
-
E
RN
G
ETYP
V
Q
D
D
A
HW
L
E
R
Y
QQL
W
S
Q
YR
DRVIG
TQ
E
L
V
A
IV
L
A
E
KDH
W
E
Q
DL
T
Q
V
P
G
L
V
E
Q
V
AN
D
L
DA
I
L
E
K
G
M
REAVR
P
LC
fig|585035.6.peg.1589
Escherichia coli S88
MKTLNRRDFPGAQ
Y
P
E
RI
IQ
FG
E
G
N
F
L
RA
FVDW
Q
I
D
L
L
N
E
H
TD
L
NS
G
VVV
V
R
P
IE
T
S
-
--
F
PPS
L
ST
Q
DG
LYT
T
I
IRGLN
EKG
E
AV
SDA
R
L
I
R
SV
N
REI
S
V
Y
S
E
Y
D
E---
F
L
KLAHN
P
E
M
RF
V
FSN
T
TE
A
G
IS
Y
H
-
A
G
D
K
F
D
-
D
A
P
A
V
S
Y
--
-
--
--
P
A
KL
T
R
L
L
F
E
RF
SH
FNG
A
LD
K
G
WII
I
P
C
EL
I
DY
NG
DA
L
R
E
L
VL
R
Y
AQ
E
W
A
L
PE
AFI
Q
W
L
D
Q
A
N
SF
C
S
T
L
VDRIV
TGYP
R
D
E
V
A
KL
E
E
E
LG
Y
HD
GFLD
T
A
E
H
F
Y
LF
VI
QGPKSLATELRL
D
KY
-
-
---
-
-
-PL
N
V
L
I
V
D
D
I
K
PY
K
E
R
K
VAI
LNG
A
H
TA
L
VPVAFQ
A
G
LD
T
V
G
E
A
M
N
D
AEI
C
A
FV
EK
AI
Y
EE
II
P
V
L
D
LP
R
-
D
E
L
ES
F
A
SA
VT
G
RF
R
NP
Y
I
KHQ
LLS
IA
LN
G
MT
K
FRTRI
LPQ
-
LLAG
Q
K
-
--
A
NGT
L
P
AR
L
TFAL
A
ALIAF
YR
G
-
E
RN
G
ETYP
V
Q
D
D
A
HW
L
E
R
Y
QQL
W
S
Q
YR
DRVIG
TQ
E
L
V
A
IV
L
A
E
KDH
W
E
Q
DL
T
Q
V
P
G
L
V
E
Q
V
AN
D
L
DA
I
L
E
K
G
M
REAVR
P
LC
fig|869729.3.peg.1998
Escherichia coli UM146
MKTLNRRDFPGAQ
Y
P
E
RI
IQ
FG
E
G
N
F
L
RA
FVDW
Q
I
D
L
L
N
E
H
TD
L
NS
G
VVV
V
R
P
IE
T
S
-
--
F
PPS
L
ST
Q
DG
LYT
T
I
IRGLN
EKG
E
AV
SDA
R
L
I
R
SV
N
REI
S
V
Y
S
E
Y
D
E---
F
L
KLAHN
P
E
M
RF
V
FSN
T
TE
A
G
IS
Y
H
-
A
G
D
K
F
D
-
D
A
P
A
V
S
Y
--
-
--
--
P
A
KL
T
R
L
L
F
E
RF
SH
FNG
A
LD
K
G
WII
I
P
C
EL
I
DY
NG
DA
L
R
E
L
VL
R
Y
AQ
E
W
A
L
PE
AFI
Q
W
L
D
Q
A
N
SF
C
S
T
L
VDRIV
TGYP
R
D
E
V
A
KL
E
E
E
LG
Y
HD
GFLD
T
A
E
H
F
Y
LF
VI
QGPKSLATELRL
D
KY
-
-
---
-
-
-PL
N
V
L
I
V
D
D
I
K
PY
K
E
R
K
VAI
LNG
A
H
TA
L
VPVAFQ
A
G
LD
T
V
G
E
A
M
N
D
AEI
C
A
FV
EK
AI
Y
EE
II
P
V
L
D
LP
R
-
D
E
L
ES
F
A
SA
VT
G
RF
R
NP
Y
I
KHQ
LLS
IA
LN
G
MT
K
FRTRI
LPQ
-
LLAG
Q
K
-
--
A
NGT
L
P
AR
L
TFAL
A
ALIAF
YR
G
-
E
RN
G
ETYP
V
Q
D
D
A
HW
L
E
R
Y
QQL
W
S
Q
YR
DRVIG
TQ
E
L
V
A
IV
L
A
E
KDH
W
E
Q
DL
T
Q
V
P
G
L
V
E
Q
V
AN
D
L
DA
I
L
E
K
G
M
REAVR
P
LC
fig|364106.7.peg.1781
Escherichia coli UTI89
MKTLNRRDFPGAQ
Y
P
E
RI
IQ
FG
E
G
N
F
L
RA
FVDW
Q
I
D
L
L
N
E
H
TD
L
NS
G
VVV
V
R
P
IE
T
S
-
--
F
PPS
L
ST
Q
DG
LYT
T
I
IRGLN
EKG
E
AV
SDA
R
L
I
R
SV
N
REI
S
V
Y
S
E
Y
D
E---
F
L
KLAHN
P
E
M
RF
V
FSN
T
TE
A
G
IS
Y
H
-
A
G
D
K
F
D
-
D
A
P
A
V
S
Y
--
-
--
--
P
A
KL
T
R
L
L
F
E
RF
SH
FNG
A
LD
K
G
WII
I
P
C
EL
I
DY
NG
DA
L
R
E
L
VL
R
Y
AQ
E
W
A
L
PE
AFI
Q
W
L
D
Q
A
N
SF
C
S
T
L
VDRIV
TGYP
R
D
E
V
A
KL
E
E
E
LG
Y
HD
GFLD
T
A
E
H
F
Y
LF
VI
QGPKSLATELRL
D
KY
-
-
---
-
-
-PL
N
V
L
I
V
D
D
I
K
PY
K
E
R
K
VAI
LNG
A
H
TA
L
VPVAFQ
A
G
LD
T
V
G
E
A
M
N
D
AEI
C
A
FV
EK
AI
Y
EE
II
P
V
L
D
LP
R
-
D
E
L
ES
F
A
SA
VT
G
RF
R
NP
Y
I
KHQ
LLS
IA
LN
G
MT
K
FRTRI
LPQ
-
LLAG
Q
K
-
--
A
NGT
L
P
AR
L
TFAL
A
ALIAF
YR
G
-
E
RN
G
ETYP
V
Q
D
D
A
HW
L
E
R
Y
QQL
W
S
Q
YR
DRVIG
TQ
E
L
V
A
IV
L
A
E
KDH
W
E
Q
DL
T
Q
V
P
G
L
V
E
Q
V
AN
D
L
DA
I
L
E
K
G
M
REAVR
P
LC
fig|364106.8.peg.1784
Escherichia coli UTI89
MKTLNRRDFPGAQ
Y
P
E
RI
IQ
FG
E
G
N
F
L
RA
FVDW
Q
I
D
L
L
N
E
H
TD
L
NS
G
VVV
V
R
P
IE
T
S
-
--
F
PPS
L
ST
Q
DG
LYT
T
I
IRGLN
EKG
E
AV
SDA
R
L
I
R
SV
N
REI
S
V
Y
S
E
Y
D
E---
F
L
KLAHN
P
E
M
RF
V
FSN
T
TE
A
G
IS
Y
H
-
A
G
D
K
F
D
-
D
A
P
A
V
S
Y
--
-
--
--
P
A
KL
T
R
L
L
F
E
RF
SH
FNG
A
LD
K
G
WII
I
P
C
EL
I
DY
NG
DA
L
R
E
L
VL
R
Y
AQ
E
W
A
L
PE
AFI
Q
W
L
D
Q
A
N
SF
C
S
T
L
VDRIV
TGYP
R
D
E
V
A
KL
E
E
E
LG
Y
HD
GFLD
T
A
E
H
F
Y
LF
VI
QGPKSLATELRL
D
KY
-
-
---
-
-
-PL
N
V
L
I
V
D
D
I
K
PY
K
E
R
K
VAI
LNG
A
H
TA
L
VPVAFQ
A
G
LD
T
V
G
E
A
M
N
D
AEI
C
A
FV
EK
AI
Y
EE
II
P
V
L
D
LP
R
-
D
E
L
ES
F
A
SA
VT
G
RF
R
NP
Y
I
KHQ
LLS
IA
LN
G
MT
K
FRTRI
LPQ
-
LLAG
Q
K
-
--
A
NGT
L
P
AR
L
TFAL
A
ALIAF
YR
G
-
E
RN
G
ETYP
V
Q
D
D
A
HW
L
E
R
Y
QQL
W
S
Q
YR
DRVIG
TQ
E
L
V
A
IV
L
A
E
KDH
W
E
Q
DL
T
Q
V
P
G
L
V
E
Q
V
AN
D
L
DA
I
L
E
K
G
M
REAVR
P
LC
fig|562.376.peg.2997
Escherichia coli WV_060327
MKTLNRRDFPGAQ
Y
P
E
RI
IQ
FG
E
G
N
F
L
RA
FVDW
Q
I
D
L
L
N
E
H
TD
L
NS
G
VVV
V
R
P
IE
T
S
-
--
F
PPS
L
ST
Q
DG
LYT
T
I
IRGLN
EKG
E
AV
SDA
R
L
I
R
SV
N
REI
S
V
Y
S
E
Y
D
E---
F
L
KLAHN
P
E
M
RF
V
FSN
T
TE
A
G
IS
Y
H
-
A
G
D
K
F
D
-
D
A
P
A
V
S
Y
--
-
--
--
P
A
KL
T
R
L
L
F
E
RF
SH
FNG
A
LD
K
G
WII
I
P
C
EL
I
DY
NG
DA
L
R
E
L
VL
R
Y
AQ
E
W
A
L
PE
AFI
Q
W
L
D
Q
A
N
SF
C
S
T
L
VDRIV
TGYP
R
D
E
V
A
KL
E
E
E
LG
Y
HD
GFLD
T
A
E
H
F
Y
LF
VI
QGPKSLATELRL
D
KY
-
-
---
-
-
-PL
N
V
L
I
V
D
D
I
K
PY
K
E
R
K
VAI
LNG
A
H
TA
L
VPVAFQ
A
G
LD
T
V
G
E
A
M
N
D
AEI
C
A
FV
EK
AI
Y
EE
II
P
V
L
D
LP
R
-
D
E
L
ES
F
A
SA
VT
G
RF
R
NP
Y
I
KHQ
LLS
IA
LN
G
MT
K
FRTRI
LPQ
-
LLAG
Q
K
-
--
A
NGT
L
P
AR
L
TFAL
A
ALIAF
YR
G
-
E
RN
G
ETYP
V
Q
D
D
A
HW
L
E
R
Y
QQL
W
S
Q
YR
DRVIG
TQ
E
L
V
A
IV
L
A
E
KDH
W
E
Q
DL
T
Q
V
P
G
L
V
E
Q
V
AN
D
L
DA
I
L
E
K
G
M
REAVR
P
LC
fig|340185.3.peg.2645
Escherichia coli E22
MKTLNRRDFPGAQ
Y
P
E
RI
IQ
FG
E
G
N
F
L
RA
FVDW
Q
I
D
L
L
N
E
H
TD
L
NS
G
VVV
V
R
P
IE
T
S
-
--
F
PPS
L
ST
Q
XG
LYT
T
I
IRGLN
EKG
E
AV
SDA
R
L
I
R
SV
N
REI
S
V
Y
S
E
Y
D
E---
F
L
KLAHN
P
E
M
RF
V
FSN
T
TE
A
G
IS
Y
H
-
A
G
D
K
F
D
-
D
A
P
A
V
S
Y
--
-
--
--
P
A
KL
T
R
L
L
F
E
RF
SH
FNG
A
LD
K
G
WII
I
P
C
EL
I
DY
NG
DA
L
R
E
L
VL
R
Y
AQ
E
W
A
L
PE
AFI
Q
W
L
D
Q
A
N
SF
C
S
T
L
VDRIV
TGYP
R
D
E
V
A
KL
E
E
E
LG
Y
HD
GFLD
T
A
E
H
F
Y
LF
VI
QGPKSLATELRL
D
KY
-
-
---
-
-
-PL
N
V
L
I
V
D
D
I
K
PY
K
E
R
K
VAI
LNG
A
H
TA
L
VPVAFQ
A
G
LD
T
V
G
E
A
M
N
D
AEI
C
A
FV
EK
AI
Y
EE
II
P
V
L
D
LP
R
-
D
E
L
ES
F
A
SA
VT
G
RF
R
NP
Y
I
KHQ
LLS
IA
LN
G
MT
K
FRTRI
LPQ
-
LLAG
Q
K
-
--
A
NGT
L
P
AR
L
TFAL
A
ALIAF
YR
G
-
E
RN
G
ETYP
V
Q
D
D
A
HW
L
E
R
Y
QQL
W
S
Q
HR
DRVIG
TQ
E
L
V
A
IV
L
A
E
KDH
W
E
Q
DL
T
Q
V
P
G
L
V
E
Q
V
AN
D
L
DA
I
L
E
K
G
M
REAVR
P
LC
fig|340185.4.peg.2788
Escherichia coli E22
MKTLNRRDFPGAQ
Y
P
E
RI
IQ
FG
E
G
N
F
L
RA
FVDW
Q
I
D
L
L
N
E
H
TD
L
NS
G
VVV
V
R
P
IE
T
S
-
--
F
PPS
L
ST
Q
XG
LYT
T
I
IRGLN
EKG
E
AV
SDA
R
L
I
R
SV
N
REI
S
V
Y
S
E
Y
D
E---
F
L
KLAHN
P
E
M
RF
V
FSN
T
TE
A
G
IS
Y
H
-
A
G
D
K
F
D
-
D
A
P
A
V
S
Y
--
-
--
--
P
A
KL
T
R
L
L
F
E
RF
SH
FNG
A
LD
K
G
WII
I
P
C
EL
I
DY
NG
DA
L
R
E
L
VL
R
Y
AQ
E
W
A
L
PE
AFI
Q
W
L
D
Q
A
N
SF
C
S
T
L
VDRIV
TGYP
R
D
E
V
A
KL
E
E
E
LG
Y
HD
GFLD
T
A
E
H
F
Y
LF
VI
QGPKSLATELRL
D
KY
-
-
---
-
-
-PL
N
V
L
I
V
D
D
I
K
PY
K
E
R
K
VAI
LNG
A
H
TA
L
VPVAFQ
A
G
LD
T
V
G
E
A
M
N
D
AEI
C
A
FV
EK
AI
Y
EE
II
P
V
L
D
LP
R
-
D
E
L
ES
F
A
SA
VT
G
RF
R
NP
Y
I
KHQ
LLS
IA
LN
G
MT
K
FRTRI
LPQ
-
LLAG
Q
K
-
--
A
NGT
L
P
AR
L
TFAL
A
ALIAF
YR
G
-
E
RN
G
ETYP
V
Q
D
D
A
HW
L
E
R
Y
QQL
W
S
Q
HR
DRVIG
TQ
E
L
V
A
IV
L
A
E
KDH
W
E
Q
DL
T
Q
V
P
G
L
V
E
Q
V
AN
D
L
DA
I
L
E
K
G
M
REAVR
P
LC
fig|550677.3.peg.2937
Escherichia coli B354
MKTLNRRDFPGAQ
Y
P
E
RI
IQ
FG
E
G
N
F
L
RA
FVDW
Q
I
D
L
L
N
E
H
TD
L
NS
G
VVV
V
R
P
IE
T
S
-
--
F
PPS
L
ST
Q
DG
LYT
T
V
IRGLN
EKG
E
AV
SDA
R
L
I
R
SV
N
REI
S
V
Y
S
E
Y
D
E---
F
L
KLAHN
P
E
M
RF
V
FSN
T
TE
A
G
IS
Y
H
-
A
G
D
K
F
D
-
D
A
P
A
V
S
Y
--
-
--
--
P
A
KL
T
R
L
L
F
E
RF
SH
FNG
A
LD
K
G
WII
I
P
C
EL
I
DY
NG
DA
L
R
E
L
VL
R
Y
AQ
E
W
A
L
PE
AFI
Q
W
L
D
Q
A
N
SF
C
S
T
L
VDRIV
TGYP
R
D
E
V
A
KL
E
E
E
LG
Y
HD
GFLD
T
A
E
H
F
Y
LF
VI
QGPKSLATELRL
D
KY
-
-
---
-
-
-PL
N
V
L
I
V
D
D
I
K
PY
K
E
R
K
VAI
LNG
A
H
TA
L
VPVAFQ
A
G
LD
T
V
G
E
A
M
N
D
AEI
C
A
FV
EK
AI
Y
EE
II
P
V
L
D
LP
R
-
D
E
L
ES
F
A
SA
VT
G
RF
R
NP
Y
I
KHQ
LLS
IA
LN
G
MT
K
FRTRI
LPQ
-
LLAG
Q
K
-
--
A
NGT
L
P
AR
L
TFAL
A
ALIAF
YR
G
-
E
RN
G
ETYP
V
Q
D
D
A
HW
L
E
R
Y
QQL
W
S
Q
HR
DRVIG
TQ
E
L
V
A
IV
L
A
E
KDH
W
E
Q
DL
T
Q
V
P
G
L
V
E
Q
V
AK
D
L
DA
I
L
E
K
G
M
REAVR
P
LC
fig|749531.3.peg.743
Escherichia coli MS 69-1
MKTLNRRDFPGAQ
Y
P
E
RI
IQ
FG
E
G
N
F
L
RA
FVDW
Q
I
D
L
L
N
E
H
TD
L
NS
G
VVV
V
R
P
IE
T
S
-
--
F
PPS
L
ST
Q
DG
LYT
T
I
IRGLN
EKG
E
AV
SDA
R
L
I
R
SV
N
REI
S
V
Y
S
E
F
D
E---
F
L
KLAHN
P
E
M
RF
V
FSN
T
TE
A
G
IS
Y
H
-
A
G
D
K
F
D
-
D
A
P
A
V
S
Y
--
-
--
--
P
A
KL
T
R
L
L
F
E
RF
SH
FNG
A
LD
K
G
WII
I
P
C
EL
I
DY
NG
DA
L
R
E
L
VL
R
Y
AQ
E
W
A
L
PE
AFI
Q
W
L
D
Q
A
N
SF
C
S
T
L
VDRIV
TGYP
R
D
E
V
A
KL
E
E
E
LG
Y
HD
GFLD
T
A
E
H
F
Y
LF
VI
QGPKSLATELRL
D
KY
-
-
---
-
-
-PL
N
V
L
I
V
D
D
I
K
PY
K
E
R
K
VAI
LNG
A
H
TA
L
VPVAFQ
A
G
LD
T
V
G
E
A
M
N
D
AEI
C
A
FV
EK
AI
Y
EE
II
P
V
L
D
LP
R
-
D
E
L
ES
F
A
SA
VT
G
RF
R
NP
Y
I
KHQ
LLS
IA
LN
G
MT
K
FRTRI
LPQ
-
LLAG
Q
K
-
--
A
NGT
L
P
AR
L
TFAL
A
ALIAF
YR
G
-
E
RN
G
ETYP
V
Q
D
D
A
HW
L
E
R
Y
QQL
W
S
Q
HR
DRVIG
TQ
E
L
V
A
IV
L
A
E
KDH
W
E
Q
DL
T
Q
V
P
G
L
V
E
Q
V
AN
D
L
D
V
I
L
E
K
G
M
REAVR
P
LC
fig|656393.3.peg.2272
Escherichia coli H299
MKTLNRRDFPGAQ
Y
P
E
RI
IQ
FG
E
G
N
F
L
RA
FVDW
Q
I
D
L
L
N
E
H
TD
L
NS
G
VVV
V
R
P
IE
T
S
-
--
F
PPS
L
ST
Q
DG
LYT
T
I
IRGLN
EKG
E
AV
SDA
R
L
I
R
SV
N
REI
S
V
Y
S
E
Y
D
E---
F
L
KLAHN
P
E
M
RF
V
FSN
T
TE
A
G
IS
Y
H
-
A
G
D
K
F
D
-
D
A
P
A
V
S
Y
--
-
--
--
P
A
KL
T
R
L
L
F
E
RF
SH
FNG
A
LD
K
G
WII
I
P
C
EL
I
DY
NG
DA
L
R
E
L
VL
R
Y
AQ
E
W
A
L
PE
AFI
Q
W
L
D
Q
A
N
SF
C
S
T
L
VDRIV
TGYP
R
D
E
V
A
KL
E
E
E
LG
Y
HD
GFLD
T
A
E
H
F
Y
LF
VI
QGPKSLATELRL
D
KY
-
-
---
-
-
-PL
N
V
L
I
V
D
D
I
K
PY
K
E
R
K
VAI
LNG
A
H
TA
L
VPVAFQ
A
G
LD
T
V
G
E
A
M
N
D
AEI
C
A
FV
EK
AI
Y
EE
II
P
V
L
D
LP
R
-
D
E
L
ES
F
A
SA
VT
G
RF
R
NP
Y
I
KHQ
LLS
IA
LN
G
MT
K
FRTRI
LPQ
-
LLAG
Q
K
-
--
A
NGT
L
P
AR
L
TFAL
A
ALIAF
YR
G
-
E
RN
G
ETYP
V
Q
D
D
A
HW
L
E
R
Y
QQL
W
S
Q
HR
DRVIG
IQ
E
L
V
A
IV
L
A
E
KDH
W
E
Q
DL
T
Q
V
P
G
L
V
E
Q
V
AN
D
L
DA
I
L
K
K
G
M
REAVR
P
LC
fig|685038.3.peg.1515
Escherichia coli O83:H1 str. NRG 857C
MKTLNRRDFPGAQ
Y
P
E
RI
IQ
FG
E
G
N
F
L
RA
FVDW
Q
I
D
L
L
N
E
H
TD
L
NS
G
VVV
V
R
P
IE
T
S
-
--
F
PPS
L
ST
Q
DG
LYT
T
I
IRGLN
EKG
E
AV
SDA
R
L
I
R
SV
N
REI
S
V
Y
S
E
Y
D
E---
F
L
KLAHN
P
E
M
RF
V
FSN
T
TE
A
G
IS
Y
H
-
A
G
D
K
F
D
-
D
A
P
A
V
S
Y
--
-
--
--
P
A
KL
T
R
L
L
F
E
RF
SH
FNG
A
LD
K
G
WII
I
P
C
EL
I
DY
NG
DA
L
R
E
L
VL
R
Y
AQ
E
W
A
L
PE
AFI
Q
W
L
D
Q
A
N
SF
C
S
T
L
VDRIV
TGYP
R
D
E
V
A
KL
E
E
E
LG
Y
HD
GFLD
T
A
E
H
F
Y
LF
VI
QGPKSLATELRL
D
KY
-
-
---
-
-
-PL
N
V
L
I
V
D
D
I
K
PY
K
E
R
K
VAI
LNG
A
H
TA
L
VPVAFQ
A
G
LD
T
V
G
E
A
M
N
D
AEI
C
A
FV
EK
AI
Y
EE
II
P
V
L
D
LP
R
-
D
E
L
ES
F
A
SA
VT
G
RF
R
NP
Y
I
KHQ
LLS
IA
LN
G
MT
K
FRTRI
LPQ
-
LLAG
Q
K
-
--
V
NGT
L
P
AR
L
TFAL
A
ALIAF
YR
G
-
E
RN
G
ETYP
V
Q
D
D
A
HW
L
E
R
Y
QQL
W
S
Q
YR
DRVIG
TQ
E
L
V
A
IV
L
A
E
KDH
W
E
Q
DL
T
Q
V
P
G
L
V
E
Q
V
AN
D
L
DA
I
L
E
K
G
M
REAVR
P
LC
fig|749527.3.peg.4607
Escherichia coli MS 21-1
MKTLNRRDFPGAQ
Y
P
E
RI
IQ
FG
E
G
N
F
L
RA
FVDW
Q
I
D
L
L
N
E
H
TD
L
NS
G
VVV
V
R
P
IE
T
S
-
--
F
PPS
L
ST
Q
DG
LYT
T
I
IRGLN
EKG
E
AV
SDA
R
L
I
R
SV
N
REI
S
V
Y
S
E
Y
D
E---
F
L
KLAHN
P
E
M
RF
V
FSN
T
TE
A
G
IS
Y
H
-
A
G
D
K
F
D
-
D
A
P
A
V
S
Y
--
-
--
--
P
A
KL
T
R
L
L
F
E
RF
SH
FNG
A
Q
D
K
G
WII
I
P
C
EL
I
DY
NG
DA
L
R
E
L
VL
R
Y
AQ
E
W
A
L
PE
AFI
Q
W
L
D
Q
A
N
SF
C
S
T
L
VDRIV
TGYP
R
D
E
V
A
KL
E
E
E
LG
Y
HD
GFLD
T
A
E
H
F
Y
LF
VI
QGPKSLATELRL
D
KY
-
-
---
-
-
-PL
N
V
L
I
V
D
D
I
K
PY
K
E
R
K
VAI
LNG
A
H
TA
L
VPVAFQ
A
G
LD
T
V
G
E
A
M
N
D
AEI
C
A
FV
EK
AI
Y
EE
II
P
V
L
D
LP
R
-
D
E
L
ES
F
A
SA
VT
G
RF
R
NP
Y
I
KHQ
LLS
IA
LN
G
MT
K
FRTRI
LPQ
-
LLAG
Q
K
-
--
A
NGT
L
P
AR
L
TFAL
A
ALIAF
YR
G
-
E
RN
G
ETYP
V
Q
D
D
A
HW
L
E
R
Y
QQL
W
S
Q
HR
DRVIG
TQ
E
L
V
A
IV
L
A
E
KDH
W
K
Q
DL
T
Q
V
P
G
L
V
E
Q
V
AN
D
L
DA
I
L
E
K
G
M
REAVR
P
LC
fig|83333.1.peg.1508
Escherichia coli K12
MKTLNRRDFPGAQ
Y
P
E
RI
IQ
FG
E
G
N
F
L
RA
FVDW
Q
I
D
L
L
N
E
H
TD
L
NS
G
VVV
V
R
P
IE
T
S
-
--
F
PPS
L
ST
Q
DG
LYT
T
I
IRGLN
EKG
E
AV
SDA
R
L
I
R
SV
N
REI
S
V
Y
S
E
Y
D
E---
F
L
KLAHN
P
E
M
RF
V
FSN
T
TE
A
G
IS
Y
H
-
A
G
D
K
F
D
-
D
A
P
A
V
S
Y
--
-
--
--
P
A
KL
T
R
L
L
F
E
RF
SH
FNG
A
LD
K
G
WII
I
P
C
EL
I
DY
NG
DA
L
R
E
L
VL
R
Y
AQ
E
W
A
L
PE
AFI
Q
W
L
D
Q
A
N
SF
C
S
T
L
VDRIV
TGYP
R
D
E
V
A
KL
E
E
E
LG
Y
HD
GFLD
T
A
E
H
F
Y
LF
VI
QGPKSLATELRL
D
KY
-
-
---
-
-
-PL
N
V
L
I
V
D
D
I
K
PY
K
E
R
K
VAI
LNG
A
H
TA
L
VPVAFQ
A
G
LD
T
V
G
E
A
M
N
D
AEI
C
A
FV
EK
AI
Y
EE
II
P
V
L
D
L
L
R
-
D
E
L
ES
F
A
SA
VT
G
RF
R
NP
Y
I
KHQ
LLS
IA
LN
G
MT
K
FRTRI
LPQ
-
LLAG
Q
K
-
--
A
NGT
L
P
AR
L
TFAL
A
ALIAF
YR
G
-
E
RN
G
ETYP
V
Q
D
D
A
HW
L
E
R
Y
QQL
W
S
Q
HR
DRVIG
TQ
E
L
V
A
IV
L
A
E
KDH
W
E
Q
DL
T
Q
V
P
G
L
V
E
Q
V
AN
D
L
DA
I
L
E
K
G
M
REAVR
P
LC
fig|525281.3.peg.1013
Escherichia coli 83972
MKTLNRRDFPGAQ
Y
P
E
RI
IQ
FG
E
G
N
F
L
RA
FVDW
Q
I
D
L
L
N
E
H
T
N
L
NS
G
VVV
V
R
P
IE
T
S
-
--
F
PPS
L
ST
Q
DG
LYT
T
I
IRGLN
EKG
E
AV
SDA
R
L
I
R
SV
N
REI
S
V
Y
S
E
Y
D
E---
F
L
KLAHN
P
E
M
RF
V
FSN
T
TE
A
G
IS
Y
H
-
A
G
D
K
F
D
-
D
A
P
A
V
S
Y
--
-
--
--
P
A
KL
T
R
L
L
F
E
RF
SH
FNG
A
LD
K
G
WII
I
P
C
EL
I
DY
NG
DA
L
R
E
L
VL
R
Y
AQ
E
W
A
L
PE
AFI
Q
W
L
D
Q
A
N
SF
C
S
T
L
VDRIV
TGYP
R
D
E
V
A
KL
E
E
E
LG
Y
HD
GFLD
T
A
E
H
F
Y
LF
VI
QGPKSLATELRL
D
KY
-
-
---
-
-
-PL
N
V
L
I
V
D
D
I
K
PY
K
E
R
K
VAI
LNG
A
H
TA
L
VPVAFQ
A
G
LD
T
V
G
E
A
M
N
D
AEI
C
A
FV
EK
AI
Y
EE
II
P
V
L
D
LP
R
-
D
E
L
ES
F
A
SA
VT
G
RF
R
NP
Y
I
KHQ
LLS
IA
LN
G
MT
K
FRTRI
LPQ
-
LLAG
Q
K
-
--
A
NGT
L
P
AR
L
TFAL
A
ALIAF
YR
G
-
E
RN
G
ETYP
V
Q
D
D
A
HW
L
E
R
Y
QQL
W
S
Q
YR
DRVIG
TQ
E
L
V
A
IV
L
A
E
KDH
W
E
Q
DL
T
Q
V
P
G
L
V
E
Q
V
AN
D
L
DA
I
L
E
K
G
M
REAVR
P
LC
fig|655817.3.peg.1830
Escherichia coli ABU 83972
MKTLNRRDFPGAQ
Y
P
E
RI
IQ
FG
E
G
N
F
L
RA
FVDW
Q
I
D
L
L
N
E
H
T
N
L
NS
G
VVV
V
R
P
IE
T
S
-
--
F
PPS
L
ST
Q
DG
LYT
T
I
IRGLN
EKG
E
AV
SDA
R
L
I
R
SV
N
REI
S
V
Y
S
E
Y
D
E---
F
L
KLAHN
P
E
M
RF
V
FSN
T
TE
A
G
IS
Y
H
-
A
G
D
K
F
D
-
D
A
P
A
V
S
Y
--
-
--
--
P
A
KL
T
R
L
L
F
E
RF
SH
FNG
A
LD
K
G
WII
I
P
C
EL
I
DY
NG
DA
L
R
E
L
VL
R
Y
AQ
E
W
A
L
PE
AFI
Q
W
L
D
Q
A
N
SF
C
S
T
L
VDRIV
TGYP
R
D
E
V
A
KL
E
E
E
LG
Y
HD
GFLD
T
A
E
H
F
Y
LF
VI
QGPKSLATELRL
D
KY
-
-
---
-
-
-PL
N
V
L
I
V
D
D
I
K
PY
K
E
R
K
VAI
LNG
A
H
TA
L
VPVAFQ
A
G
LD
T
V
G
E
A
M
N
D
AEI
C
A
FV
EK
AI
Y
EE
II
P
V
L
D
LP
R
-
D
E
L
ES
F
A
SA
VT
G
RF
R
NP
Y
I
KHQ
LLS
IA
LN
G
MT
K
FRTRI
LPQ
-
LLAG
Q
K
-
--
A
NGT
L
P
AR
L
TFAL
A
ALIAF
YR
G
-
E
RN
G
ETYP
V
Q
D
D
A
HW
L
E
R
Y
QQL
W
S
Q
YR
DRVIG
TQ
E
L
V
A
IV
L
A
E
KDH
W
E
Q
DL
T
Q
V
P
G
L
V
E
Q
V
AN
D
L
DA
I
L
E
K
G
M
REAVR
P
LC
fig|749528.3.peg.3894
Escherichia coli MS 45-1
MKTLNRRDFPGAQ
Y
P
E
RI
IQ
FG
E
G
N
F
L
RA
FVDW
Q
I
D
L
L
N
E
H
T
N
L
NS
G
VVV
V
R
P
IE
T
S
-
--
F
PPS
L
ST
Q
DG
LYT
T
I
IRGLN
EKG
E
AV
SDA
R
L
I
R
SV
N
REI
S
V
Y
S
E
Y
D
E---
F
L
KLAHN
P
E
M
RF
V
FSN
T
TE
A
G
IS
Y
H
-
A
G
D
K
F
D
-
D
A
P
A
V
S
Y
--
-
--
--
P
A
KL
T
R
L
L
F
E
RF
SH
FNG
A
LD
K
G
WII
I
P
C
EL
I
DY
NG
DA
L
R
E
L
VL
R
Y
AQ
E
W
A
L
PE
AFI
Q
W
L
D
Q
A
N
SF
C
S
T
L
VDRIV
TGYP
R
D
E
V
A
KL
E
E
E
LG
Y
HD
GFLD
T
A
E
H
F
Y
LF
VI
QGPKSLATELRL
D
KY
-
-
---
-
-
-PL
N
V
L
I
V
D
D
I
K
PY
K
E
R
K
VAI
LNG
A
H
TA
L
VPVAFQ
A
G
LD
T
V
G
E
A
M
N
D
AEI
C
A
FV
EK
AI
Y
EE
II
P
V
L
D
LP
R
-
D
E
L
ES
F
A
SA
VT
G
RF
R
NP
Y
I
KHQ
LLS
IA
LN
G
MT
K
FRTRI
LPQ
-
LLAG
Q
K
-
--
A
NGT
L
P
AR
L
TFAL
A
ALIAF
YR
G
-
E
RN
G
ETYP
V
Q
D
D
A
HW
L
E
R
Y
QQL
W
S
Q
YR
DRVIG
TQ
E
L
V
A
IV
L
A
E
KDH
W
E
Q
DL
T
Q
V
P
G
L
V
E
Q
V
AN
D
L
DA
I
L
E
K
G
M
REAVR
P
LC
fig|316385.5.peg.1634
Escherichia coli str. K-12 substr. DH10B
MKTLNRRDFPGAQ
Y
P
E
RI
IQ
FG
E
G
N
F
L
RA
FVDW
Q
I
D
L
L
N
E
H
TD
L
NS
G
VVV
V
R
P
IE
T
S
-
--
F
PPS
L
ST
Q
DG
LYT
T
I
IRGLN
EKG
K
AV
SDA
R
L
I
R
SV
N
REI
S
V
Y
S
E
Y
D
E---
F
L
KLAHN
P
E
M
RF
V
FSN
T
TE
A
G
IS
Y
H
-
A
G
D
K
F
D
-
D
A
P
A
V
S
Y
--
-
--
--
P
A
KL
T
R
L
L
F
E
RF
SH
FNG
A
LD
K
G
WII
I
P
C
EL
I
DY
NG
DA
L
R
E
L
VL
R
Y
AQ
E
W
A
L
PE
AFI
Q
W
L
A
Q
A
N
SF
C
S
T
L
VDRIV
TGYP
R
D
E
V
A
KL
E
E
E
LG
Y
HD
GFLD
T
A
E
H
F
Y
LF
VI
QGPKSLATELRL
D
KY
-
-
---
-
-
-PL
N
V
L
I
V
D
D
I
K
PY
K
E
R
K
VAI
LNG
A
H
TA
L
VPVAFQ
A
G
LD
T
V
G
E
A
M
N
D
AEI
C
A
FV
EK
AI
Y
EE
II
P
V
L
D
LP
R
-
D
E
L
ES
F
A
SA
VT
G
RF
R
NP
Y
I
KHQ
LLS
IA
LN
G
MT
K
FRTRI
LPQ
-
LLAG
Q
K
-
--
A
NGT
L
P
AR
L
TFAL
A
ALIAF
YR
G
-
E
RN
G
ETYP
V
Q
D
D
A
HW
L
E
R
Y
QQL
W
S
Q
HR
DRVIG
TQ
E
L
V
A
IV
L
A
E
KDH
W
E
Q
DL
T
Q
V
P
G
L
V
E
Q
V
AN
D
L
DA
I
L
E
K
G
M
REAVR
P
LC
fig|316385.7.peg.1675
Escherichia coli str. K-12 substr. DH10B
MKTLNRRDFPGAQ
Y
P
E
RI
IQ
FG
E
G
N
F
L
RA
FVDW
Q
I
D
L
L
N
E
H
TD
L
NS
G
VVV
V
R
P
IE
T
S
-
--
F
PPS
L
ST
Q
DG
LYT
T
I
IRGLN
EKG
K
AV
SDA
R
L
I
R
SV
N
REI
S
V
Y
S
E
Y
D
E---
F
L
KLAHN
P
E
M
RF
V
FSN
T
TE
A
G
IS
Y
H
-
A
G
D
K
F
D
-
D
A
P
A
V
S
Y
--
-
--
--
P
A
KL
T
R
L
L
F
E
RF
SH
FNG
A
LD
K
G
WII
I
P
C
EL
I
DY
NG
DA
L
R
E
L
VL
R
Y
AQ
E
W
A
L
PE
AFI
Q
W
L
A
Q
A
N
SF
C
S
T
L
VDRIV
TGYP
R
D
E
V
A
KL
E
E
E
LG
Y
HD
GFLD
T
A
E
H
F
Y
LF
VI
QGPKSLATELRL
D
KY
-
-
---
-
-
-PL
N
V
L
I
V
D
D
I
K
PY
K
E
R
K
VAI
LNG
A
H
TA
L
VPVAFQ
A
G
LD
T
V
G
E
A
M
N
D
AEI
C
A
FV
EK
AI
Y
EE
II
P
V
L
D
LP
R
-
D
E
L
ES
F
A
SA
VT
G
RF
R
NP
Y
I
KHQ
LLS
IA
LN
G
MT
K
FRTRI
LPQ
-
LLAG
Q
K
-
--
A
NGT
L
P
AR
L
TFAL
A
ALIAF
YR
G
-
E
RN
G
ETYP
V
Q
D
D
A
HW
L
E
R
Y
QQL
W
S
Q
HR
DRVIG
TQ
E
L
V
A
IV
L
A
E
KDH
W
E
Q
DL
T
Q
V
P
G
L
V
E
Q
V
AN
D
L
DA
I
L
E
K
G
M
REAVR
P
LC
fig|362663.8.peg.1516
Escherichia coli 536
MKTLNRRDFPGAQ
Y
P
E
RI
IQ
FG
E
G
N
F
L
RA
FVDW
Q
I
D
L
L
N
E
H
TD
L
NS
G
VVV
V
R
P
IE
T
S
-
--
F
PPS
L
ST
Q
DG
LYT
T
I
IRGLN
EKG
E
AV
SDA
R
L
I
R
SV
N
REI
S
V
Y
S
E
Y
D
E---
F
L
KLAHN
P
E
M
RF
V
FSN
T
TE
A
G
IS
Y
H
-
A
G
D
K
F
D
-
D
A
P
A
V
S
Y
--
-
--
--
P
A
KL
T
R
L
L
F
E
RF
SH
FNG
A
LD
K
G
WII
I
P
C
EL
I
DY
NG
DA
L
R
E
L
VL
R
Y
AQ
E
W
A
L
PE
AFI
Q
W
L
D
Q
A
N
SF
C
S
T
L
VDRIV
TGYP
R
D
E
V
A
KL
E
E
E
LG
Y
HD
GFLD
T
A
E
Y
F
Y
LF
VI
QGPKSLATELRL
D
KY
-
-
---
-
-
-PL
N
V
L
I
V
D
D
I
K
PY
K
E
R
K
VAI
LNG
A
H
TA
L
VPVAFQ
A
G
LD
T
V
G
E
A
M
N
D
AEI
C
A
FV
EK
AI
Y
EE
II
P
V
L
D
LP
R
-
D
E
L
ES
F
A
SA
VT
G
RF
R
NP
Y
I
KHQ
LLS
IA
LN
G
MT
K
FRTRI
LPQ
-
LLAG
Q
K
-
--
A
NGT
L
P
AR
L
TFAL
A
ALIAF
YR
G
-
E
RN
G
ETYP
V
Q
D
D
A
HW
L
E
R
Y
QQL
W
S
Q
YR
DRVIG
TQ
E
L
V
A
IV
L
A
E
KDH
W
E
Q
DL
T
Q
V
P
G
L
V
E
Q
V
AN
D
L
DA
I
L
E
K
G
M
REAVR
P
LC
fig|362663.9.peg.1521
Escherichia coli 536
MKTLNRRDFPGAQ
Y
P
E
RI
IQ
FG
E
G
N
F
L
RA
FVDW
Q
I
D
L
L
N
E
H
TD
L
NS
G
VVV
V
R
P
IE
T
S
-
--
F
PPS
L
ST
Q
DG
LYT
T
I
IRGLN
EKG
E
AV
SDA
R
L
I
R
SV
N
REI
S
V
Y
S
E
Y
D
E---
F
L
KLAHN
P
E
M
RF
V
FSN
T
TE
A
G
IS
Y
H
-
A
G
D
K
F
D
-
D
A
P
A
V
S
Y
--
-
--
--
P
A
KL
T
R
L
L
F
E
RF
SH
FNG
A
LD
K
G
WII
I
P
C
EL
I
DY
NG
DA
L
R
E
L
VL
R
Y
AQ
E
W
A
L
PE
AFI
Q
W
L
D
Q
A
N
SF
C
S
T
L
VDRIV
TGYP
R
D
E
V
A
KL
E
E
E
LG
Y
HD
GFLD
T
A
E
Y
F
Y
LF
VI
QGPKSLATELRL
D
KY
-
-
---
-
-
-PL
N
V
L
I
V
D
D
I
K
PY
K
E
R
K
VAI
LNG
A
H
TA
L
VPVAFQ
A
G
LD
T
V
G
E
A
M
N
D
AEI
C
A
FV
EK
AI
Y
EE
II
P
V
L
D
LP
R
-
D
E
L
ES
F
A
SA
VT
G
RF
R
NP
Y
I
KHQ
LLS
IA
LN
G
MT
K
FRTRI
LPQ
-
LLAG
Q
K
-
--
A
NGT
L
P
AR
L
TFAL
A
ALIAF
YR
G
-
E
RN
G
ETYP
V
Q
D
D
A
HW
L
E
R
Y
QQL
W
S
Q
YR
DRVIG
TQ
E
L
V
A
IV
L
A
E
KDH
W
E
Q
DL
T
Q
V
P
G
L
V
E
Q
V
AN
D
L
DA
I
L
E
K
G
M
REAVR
P
LC
fig|340197.3.peg.4284
Escherichia coli F11
MKTLNRRDFPGAQ
Y
P
E
RI
IQ
FG
E
G
N
F
L
RA
FVDW
Q
I
D
L
L
N
E
H
TD
L
NS
G
VVV
V
R
P
IE
T
S
-
--
F
PPS
L
ST
Q
DG
LYT
T
I
IRGLN
EKG
E
AV
SDA
R
L
I
R
SV
N
REI
S
V
Y
S
E
Y
D
E---
F
L
KLAHN
P
E
M
RF
V
FSN
T
TE
A
G
IS
Y
H
-
A
G
D
K
F
D
-
D
A
P
A
V
S
Y
--
-
--
--
P
A
KL
T
R
L
L
F
E
RF
SH
FNG
A
LD
K
G
WII
I
P
C
EL
I
DY
NG
DA
L
R
E
L
VL
R
Y
AQ
E
W
A
L
PE
AFI
Q
W
L
D
Q
A
N
SF
C
S
T
L
VDRIV
TGYP
R
D
E
V
A
KL
E
E
E
LG
Y
HD
GFLD
T
A
E
Y
F
Y
LF
VI
QGPKSLATELRL
D
KY
-
-
---
-
-
-PL
N
V
L
I
V
D
D
I
K
PY
K
E
R
K
VAI
LNG
A
H
TA
L
VPVAFQ
A
G
LD
T
V
G
E
A
M
N
D
AEI
C
A
FV
EK
AI
Y
EE
II
P
V
L
D
LP
R
-
D
E
L
ES
F
A
SA
VT
G
RF
R
NP
Y
I
KHQ
LLS
IA
LN
G
MT
K
FRTRI
LPQ
-
LLAG
Q
K
-
--
A
NGT
L
P
AR
L
TFAL
A
ALIAF
YR
G
-
E
RN
G
ETYP
V
Q
D
D
A
HW
L
E
R
Y
QQL
W
S
Q
YR
DRVIG
TQ
E
L
V
A
IV
L
A
E
KDH
W
E
Q
DL
T
Q
V
P
G
L
V
E
Q
V
AN
D
L
DA
I
L
E
K
G
M
REAVR
P
LC
fig|340197.5.peg.4473
Escherichia coli F11
MKTLNRRDFPGAQ
Y
P
E
RI
IQ
FG
E
G
N
F
L
RA
FVDW
Q
I
D
L
L
N
E
H
TD
L
NS
G
VVV
V
R
P
IE
T
S
-
--
F
PPS
L
ST
Q
DG
LYT
T
I
IRGLN
EKG
E
AV
SDA
R
L
I
R
SV
N
REI
S
V
Y
S
E
Y
D
E---
F
L
KLAHN
P
E
M
RF
V
FSN
T
TE
A
G
IS
Y
H
-
A
G
D
K
F
D
-
D
A
P
A
V
S
Y
--
-
--
--
P
A
KL
T
R
L
L
F
E
RF
SH
FNG
A
LD
K
G
WII
I
P
C
EL
I
DY
NG
DA
L
R
E
L
VL
R
Y
AQ
E
W
A
L
PE
AFI
Q
W
L
D
Q
A
N
SF
C
S
T
L
VDRIV
TGYP
R
D
E
V
A
KL
E
E
E
LG
Y
HD
GFLD
T
A
E
Y
F
Y
LF
VI
QGPKSLATELRL
D
KY
-
-
---
-
-
-PL
N
V
L
I
V
D
D
I
K
PY
K
E
R
K
VAI
LNG
A
H
TA
L
VPVAFQ
A
G
LD
T
V
G
E
A
M
N
D
AEI
C
A
FV
EK
AI
Y
EE
II
P
V
L
D
LP
R
-
D
E
L
ES
F
A
SA
VT
G
RF
R
NP
Y
I
KHQ
LLS
IA
LN
G
MT
K
FRTRI
LPQ
-
LLAG
Q
K
-
--
A
NGT
L
P
AR
L
TFAL
A
ALIAF
YR
G
-
E
RN
G
ETYP
V
Q
D
D
A
HW
L
E
R
Y
QQL
W
S
Q
YR
DRVIG
TQ
E
L
V
A
IV
L
A
E
KDH
W
E
Q
DL
T
Q
V
P
G
L
V
E
Q
V
AN
D
L
DA
I
L
E
K
G
M
REAVR
P
LC
fig|749550.3.peg.1169
Escherichia coli MS 200-1
MKTLNRRDFPGAQ
Y
P
E
RI
IQ
FG
E
G
N
F
L
RA
FVDW
Q
I
D
L
L
N
E
H
TD
L
NS
G
VVV
V
R
P
IE
T
S
-
--
F
PPS
L
ST
Q
DG
LYT
T
I
IRGLN
EKG
E
AV
SDA
R
L
I
R
SV
N
REI
S
V
Y
S
E
Y
D
E---
F
L
KLAHN
P
E
M
RF
V
FSN
T
TE
A
G
IS
Y
H
-
A
G
D
K
F
D
-
D
A
P
A
V
S
Y
--
-
--
--
P
A
KL
T
R
L
L
F
E
RF
SH
FNG
A
LD
K
G
WII
I
P
C
EL
I
DY
NG
DA
L
R
E
L
VL
R
Y
AQ
E
W
A
L
PE
AFI
Q
W
L
D
Q
A
N
SF
C
S
T
L
VDRIV
TGYP
R
D
E
V
A
KL
E
E
E
LG
Y
HD
GFLD
T
A
E
Y
F
Y
LF
VI
QGPKSLATELRL
D
KY
-
-
---
-
-
-PL
N
V
L
I
V
D
D
I
K
PY
K
E
R
K
VAI
LNG
A
H
TA
L
VPVAFQ
A
G
LD
T
V
G
E
A
M
N
D
AEI
C
A
FV
EK
AI
Y
EE
II
P
V
L
D
LP
R
-
D
E
L
ES
F
A
SA
VT
G
RF
R
NP
Y
I
KHQ
LLS
IA
LN
G
MT
K
FRTRI
LPQ
-
LLAG
Q
K
-
--
A
NGT
L
P
AR
L
TFAL
A
ALIAF
YR
G
-
E
RN
G
ETYP
V
Q
D
D
A
HW
L
E
R
Y
QQL
W
S
Q
YR
DRVIG
TQ
E
L
V
A
IV
L
A
E
KDH
W
E
Q
DL
T
Q
V
P
G
L
V
E
Q
V
AN
D
L
DA
I
L
E
K
G
M
REAVR
P
LC
fig|155864.1.peg.1941
Escherichia coli O157:H7 EDL933
MKTLNRRDFPGAQ
Y
P
E
RI
IQ
FG
E
G
N
F
L
RA
FVDW
Q
I
D
L
L
N
E
H
TD
L
NS
G
VVV
V
R
P
XE
T
S
-
--
F
PPS
L
ST
Q
DG
LYT
T
I
IRGLN
EKG
E
AV
SDA
R
L
I
R
SV
N
REI
S
V
Y
S
E
Y
D
E---
F
L
KLAHN
P
E
M
RF
V
FSN
T
TE
A
G
IS
Y
H
-
A
G
D
K
F
D
-
D
A
P
A
V
S
Y
--
-
--
--
P
A
KL
T
R
L
L
F
E
RF
SH
FNG
A
LD
K
G
WII
I
P
C
EL
I
DY
NG
DA
L
R
E
L
VL
R
Y
AQ
E
W
A
L
PE
AFI
Q
W
L
D
Q
A
N
SF
C
S
T
L
VDRIV
TGYP
R
D
E
V
A
KL
E
E
E
LG
Y
HD
GFLD
T
A
E
H
F
Y
LF
VI
QGPKSLATELRL
D
KY
-
-
---
-
-
-PL
N
V
L
I
V
D
D
I
K
PY
K
E
R
K
VAI
LNG
A
H
TA
L
VPVAFQ
A
G
LD
T
V
G
E
A
M
N
D
AEI
C
A
FV
EK
AI
Y
EE
II
P
V
L
D
LP
R
-
D
E
L
ES
F
A
SA
VT
G
RF
R
X
P
Y
I
KHQ
LLS
IA
LN
G
MT
K
FRTRI
LPQ
-
LLAG
Q
K
-
--
A
NGT
L
P
AR
L
TFAL
A
ALIAF
YR
G
-
E
RN
G
ETYP
V
Q
D
D
A
HW
L
E
R
Y
QQL
W
S
Q
HR
DRVIG
TQ
E
L
V
A
IV
L
A
E
KDH
W
E
Q
DL
T
Q
V
P
G
L
V
E
Q
V
AN
D
L
DA
I
L
E
K
G
M
REAVR
P
LC
fig|155864.8.peg.1763
Escherichia coli O157:H7 EDL933
MKTLNRRDFPGAQ
Y
P
E
RI
IQ
FG
E
G
N
F
L
RA
FVDW
Q
I
D
L
L
N
E
H
TD
L
NS
G
VVV
V
R
P
XE
T
S
-
--
F
PPS
L
ST
Q
DG
LYT
T
I
IRGLN
EKG
E
AV
SDA
R
L
I
R
SV
N
REI
S
V
Y
S
E
Y
D
E---
F
L
KLAHN
P
E
M
RF
V
FSN
T
TE
A
G
IS
Y
H
-
A
G
D
K
F
D
-
D
A
P
A
V
S
Y
--
-
--
--
P
A
KL
T
R
L
L
F
E
RF
SH
FNG
A
LD
K
G
WII
I
P
C
EL
I
DY
NG
DA
L
R
E
L
VL
R
Y
AQ
E
W
A
L
PE
AFI
Q
W
L
D
Q
A
N
SF
C
S
T
L
VDRIV
TGYP
R
D
E
V
A
KL
E
E
E
LG
Y
HD
GFLD
T
A
E
H
F
Y
LF
VI
QGPKSLATELRL
D
KY
-
-
---
-
-
-PL
N
V
L
I
V
D
D
I
K
PY
K
E
R
K
VAI
LNG
A
H
TA
L
VPVAFQ
A
G
LD
T
V
G
E
A
M
N
D
AEI
C
A
FV
EK
AI
Y
EE
II
P
V
L
D
LP
R
-
D
E
L
ES
F
A
SA
VT
G
RF
R
X
P
Y
I
KHQ
LLS
IA
LN
G
MT
K
FRTRI
LPQ
-
LLAG
Q
K
-
--
A
NGT
L
P
AR
L
TFAL
A
ALIAF
YR
G
-
E
RN
G
ETYP
V
Q
D
D
A
HW
L
E
R
Y
QQL
W
S
Q
HR
DRVIG
TQ
E
L
V
A
IV
L
A
E
KDH
W
E
Q
DL
T
Q
V
P
G
L
V
E
Q
V
AN
D
L
DA
I
L
E
K
G
M
REAVR
P
LC
fig|431946.3.peg.1475
Escherichia coli SE15
MKTLNRRDFPGAQ
Y
P
E
RI
IQ
FG
E
G
N
F
L
RA
FVDW
Q
I
D
L
L
N
E
H
TD
L
NS
G
VVV
V
R
P
IE
T
S
-
--
F
PPS
L
ST
Q
DG
LYT
T
I
IRGLN
EKG
E
AV
SDA
R
L
I
R
SV
N
REI
S
V
Y
S
E
Y
D
E---
F
L
KLAHN
P
E
M
RF
V
FSN
T
TE
A
G
IS
Y
H
-
A
G
D
K
F
D
-
D
A
P
A
V
S
Y
--
-
--
--
P
A
KL
T
R
L
L
F
E
RF
SH
FNG
A
LD
K
G
WII
I
P
C
EL
I
DY
NG
DA
L
R
E
L
VL
R
Y
AQ
E
W
A
L
PE
AFI
Q
W
L
D
Q
A
N
SF
C
S
T
L
VDRIV
TGYP
R
D
E
V
A
KL
E
E
E
LG
Y
HD
GFLD
T
A
E
H
F
Y
LF
VI
QGPKSLATELRL
D
KY
-
-
---
-
-
-PL
N
V
L
I
V
D
D
I
K
PY
K
E
R
K
VAI
LNG
A
H
TA
L
VPVAFQ
A
G
LD
T
V
G
E
A
M
N
D
AEI
C
A
FV
EK
AI
Y
EE
II
P
V
L
D
LP
R
-
D
E
L
ES
F
A
SA
VT
G
RF
R
NP
Y
I
KHQ
LLS
IA
LN
G
MT
K
FRTRI
LPQ
-
LLAG
Q
K
-
--
A
NGT
L
P
AR
L
TFAL
A
ALIAF
YR
G
-
V
RN
G
ETYP
V
Q
D
D
A
HW
L
E
R
Y
QQL
W
S
Q
YR
DRVIG
TQ
E
L
V
A
IV
L
A
E
KDH
W
E
Q
DL
T
Q
V
P
G
L
V
E
Q
V
AN
D
L
DA
I
L
E
K
G
M
REAVR
P
LC
fig|585057.4.peg.1859
Escherichia coli IAI39
MKTLNRRDFPGAQ
Y
P
E
RI
IQ
FG
E
G
N
F
L
RA
FVDW
Q
I
D
L
L
N
E
H
TD
L
NS
G
VVV
V
R
P
IE
T
S
-
--
F
PPS
L
ST
Q
DG
LYT
T
I
IRGLN
EKG
E
AV
SDA
R
L
I
R
SV
N
REI
S
V
Y
S
E
Y
D
E---
F
L
KLAHN
P
E
M
RF
V
FSN
T
TE
A
G
IS
Y
H
-
A
G
D
K
F
D
-
D
A
P
A
V
S
Y
--
-
--
--
P
A
KL
T
R
L
L
F
E
RF
SH
FNG
A
Q
D
K
G
WII
I
P
C
EL
I
DY
NG
DA
L
R
E
L
VL
R
Y
AQ
E
W
A
L
PE
AFI
Q
W
L
D
Q
A
N
SF
C
S
T
L
VDRIV
TGYP
R
D
E
V
A
KL
E
E
E
LG
Y
HD
GFLD
T
A
E
H
F
Y
LF
VI
QGPKSLATELRL
D
KY
-
-
---
-
-
-PL
N
V
L
I
V
D
D
I
K
PY
K
E
R
K
VAI
LNG
A
H
TA
L
VPVAFQ
A
G
LD
T
V
G
E
A
M
N
D
AEI
C
A
FV
EK
AI
Y
EE
II
P
V
L
D
LP
R
-
D
E
L
ES
F
A
SA
VT
G
RF
R
NP
Y
I
KHQ
LLS
IA
LN
G
MT
K
FRTRI
LPQ
-
LLAG
Q
K
-
--
S
NGT
L
P
AR
L
TFAL
A
ALIAF
YR
G
-
E
RN
G
ETYP
V
Q
D
D
A
HW
L
E
R
Y
QQL
W
S
Q
HR
N
RVIG
TQ
E
L
V
A
IV
L
A
E
KDH
W
E
Q
DL
T
Q
V
P
G
L
V
E
Q
V
AN
D
L
DA
I
L
E
K
G
M
REAVR
P
LC
fig|585057.6.peg.1858
Escherichia coli IAI39
MKTLNRRDFPGAQ
Y
P
E
RI
IQ
FG
E
G
N
F
L
RA
FVDW
Q
I
D
L
L
N
E
H
TD
L
NS
G
VVV
V
R
P
IE
T
S
-
--
F
PPS
L
ST
Q
DG
LYT
T
I
IRGLN
EKG
E
AV
SDA
R
L
I
R
SV
N
REI
S
V
Y
S
E
Y
D
E---
F
L
KLAHN
P
E
M
RF
V
FSN
T
TE
A
G
IS
Y
H
-
A
G
D
K
F
D
-
D
A
P
A
V
S
Y
--
-
--
--
P
A
KL
T
R
L
L
F
E
RF
SH
FNG
A
Q
D
K
G
WII
I
P
C
EL
I
DY
NG
DA
L
R
E
L
VL
R
Y
AQ
E
W
A
L
PE
AFI
Q
W
L
D
Q
A
N
SF
C
S
T
L
VDRIV
TGYP
R
D
E
V
A
KL
E
E
E
LG
Y
HD
GFLD
T
A
E
H
F
Y
LF
VI
QGPKSLATELRL
D
KY
-
-
---
-
-
-PL
N
V
L
I
V
D
D
I
K
PY
K
E
R
K
VAI
LNG
A
H
TA
L
VPVAFQ
A
G
LD
T
V
G
E
A
M
N
D
AEI
C
A
FV
EK
AI
Y
EE
II
P
V
L
D
LP
R
-
D
E
L
ES
F
A
SA
VT
G
RF
R
NP
Y
I
KHQ
LLS
IA
LN
G
MT
K
FRTRI
LPQ
-
LLAG
Q
K
-
--
S
NGT
L
P
AR
L
TFAL
A
ALIAF
YR
G
-
E
RN
G
ETYP
V
Q
D
D
A
HW
L
E
R
Y
QQL
W
S
Q
HR
N
RVIG
TQ
E
L
V
A
IV
L
A
E
KDH
W
E
Q
DL
T
Q
V
P
G
L
V
E
Q
V
AN
D
L
DA
I
L
E
K
G
M
REAVR
P
LC
fig|216592.1.peg.2067
Escherichia coli 042
MKTLNRRDFPGA
K
Y
P
E
RI
IQ
FG
E
G
N
F
L
RA
FVDW
Q
I
D
L
L
N
E
H
TD
L
NS
G
VVV
V
R
P
IE
T
S
-
--
F
PPS
L
ST
Q
DG
LYT
T
I
IRGLN
EKG
E
AV
SDA
R
L
I
R
SV
N
REI
S
V
Y
S
E
Y
D
E---
F
L
KLAHN
P
E
M
RF
V
FSN
T
TE
A
G
IS
Y
H
-
A
G
D
K
F
D
-
D
A
P
A
V
S
Y
--
-
--
--
P
A
KL
T
R
L
L
F
E
RF
SH
FNG
A
Q
D
K
G
WII
I
P
C
EL
I
DY
NG
DA
L
R
E
L
VL
R
Y
AQ
E
W
A
L
PE
AFI
Q
W
L
D
Q
A
N
SF
C
S
T
L
VDRIV
TGYP
R
D
E
V
A
KL
E
E
E
LG
Y
HD
GFLD
T
A
E
H
F
Y
LF
VI
QGPKSLATELRL
D
KY
-
-
---
-
-
-PL
N
V
L
I
V
D
D
I
K
PY
K
E
R
K
VAI
LNG
A
H
TA
L
VPVAFQ
A
G
LD
T
V
G
E
A
M
N
D
AEI
C
A
FV
EK
AI
Y
EE
II
P
V
L
D
LP
R
-
D
E
L
ES
F
A
SA
VT
G
RF
R
NP
Y
I
KHQ
LLS
IA
LN
G
MT
K
FRTRI
LPQ
-
LLAG
Q
K
-
--
A
NGT
L
P
AR
L
TFAL
A
ALIAF
YR
G
-
E
RN
G
ETYP
V
Q
D
D
A
HW
L
E
R
Y
QQL
W
S
Q
HR
DRVIG
TQ
E
L
V
A
IV
L
A
E
KDH
W
E
Q
DL
T
Q
V
P
G
L
V
E
Q
V
AN
D
L
D
V
I
L
E
K
G
M
REAVR
P
LC
fig|216592.3.peg.1711
Escherichia coli 042
MKTLNRRDFPGA
K
Y
P
E
RI
IQ
FG
E
G
N
F
L
RA
FVDW
Q
I
D
L
L
N
E
H
TD
L
NS
G
VVV
V
R
P
IE
T
S
-
--
F
PPS
L
ST
Q
DG
LYT
T
I
IRGLN
EKG
E
AV
SDA
R
L
I
R
SV
N
REI
S
V
Y
S
E
Y
D
E---
F
L
KLAHN
P
E
M
RF
V
FSN
T
TE
A
G
IS
Y
H
-
A
G
D
K
F
D
-
D
A
P
A
V
S
Y
--
-
--
--
P
A
KL
T
R
L
L
F
E
RF
SH
FNG
A
Q
D
K
G
WII
I
P
C
EL
I
DY
NG
DA
L
R
E
L
VL
R
Y
AQ
E
W
A
L
PE
AFI
Q
W
L
D
Q
A
N
SF
C
S
T
L
VDRIV
TGYP
R
D
E
V
A
KL
E
E
E
LG
Y
HD
GFLD
T
A
E
H
F
Y
LF
VI
QGPKSLATELRL
D
KY
-
-
---
-
-
-PL
N
V
L
I
V
D
D
I
K
PY
K
E
R
K
VAI
LNG
A
H
TA
L
VPVAFQ
A
G
LD
T
V
G
E
A
M
N
D
AEI
C
A
FV
EK
AI
Y
EE
II
P
V
L
D
LP
R
-
D
E
L
ES
F
A
SA
VT
G
RF
R
NP
Y
I
KHQ
LLS
IA
LN
G
MT
K
FRTRI
LPQ
-
LLAG
Q
K
-
--
A
NGT
L
P
AR
L
TFAL
A
ALIAF
YR
G
-
E
RN
G
ETYP
V
Q
D
D
A
HW
L
E
R
Y
QQL
W
S
Q
HR
DRVIG
TQ
E
L
V
A
IV
L
A
E
KDH
W
E
Q
DL
T
Q
V
P
G
L
V
E
Q
V
AN
D
L
D
V
I
L
E
K
G
M
REAVR
P
LC
fig|753642.3.peg.1616
Escherichia coli NC101
MKTLNRRDFPGAQ
Y
P
E
RI
IQ
FG
E
G
N
F
L
RA
FVDW
Q
I
D
L
L
N
E
H
TD
L
NS
G
VVV
V
R
P
IE
T
S
-
--
F
PPS
L
ST
Q
DG
LYT
T
I
IRGLN
EKG
E
AV
SDA
R
L
I
R
SV
N
REI
S
V
Y
S
E
Y
D
E---
F
L
KLAHN
P
E
M
RF
V
FSN
T
TE
A
G
IS
Y
H
-
A
G
D
K
F
D
-
D
A
P
A
V
S
Y
--
-
--
--
P
A
KL
T
R
L
L
F
E
RF
SH
FNG
A
LD
K
G
WII
I
P
C
EL
I
DY
NG
DA
L
R
E
L
VL
R
Y
AQ
E
W
A
L
PE
AFI
Q
W
L
D
Q
A
N
SF
C
S
A
L
VDRIV
TGYP
R
D
E
V
A
KL
E
E
E
LG
Y
HD
GFLD
T
A
E
H
F
Y
LF
VI
QGPKSLATELRL
D
KY
-
-
---
-
-
-PL
N
V
L
I
V
D
D
I
K
PY
K
E
R
K
VAI
LNG
A
H
TA
L
VPVAFQ
A
G
LD
T
V
G
E
A
M
N
D
AEI
C
A
FV
EK
AI
Y
EE
II
P
V
L
D
LP
R
-
D
E
L
ES
F
A
SA
VT
G
RF
R
NP
Y
I
KHQ
LLS
IA
LN
G
MT
K
FRTRI
LPQ
-
LLAG
Q
K
-
--
V
NGT
L
P
AR
L
TFAL
A
ALIAF
YR
G
-
E
RN
G
ETYP
V
Q
D
D
A
HW
L
E
R
Y
QQL
W
S
Q
YR
DRVIG
TQ
E
L
V
A
IV
L
A
E
KDH
W
E
Q
DL
T
Q
V
P
G
L
V
E
Q
V
AN
D
L
DA
I
L
E
K
G
M
REAVR
P
LC
fig|749546.3.peg.3917
Escherichia coli MS 185-1
MKTLNRRDFPGAQ
Y
P
E
RI
IQ
FG
E
G
N
F
L
RA
FVDW
Q
I
D
L
L
N
E
H
T
N
L
NS
G
VVV
V
R
P
IE
T
S
-
--
F
PPS
L
ST
Q
DG
LYT
T
I
IRGLN
EKG
E
AV
SDA
R
L
I
R
SV
N
REI
S
V
Y
S
E
Y
D
E---
F
L
KLAHN
P
E
M
RF
V
FSN
T
TE
A
G
IS
Y
H
-
A
G
D
K
F
D
-
D
A
P
A
V
S
Y
--
-
--
--
P
A
KL
T
R
L
L
F
E
RF
SH
FNG
A
LD
K
G
WII
I
P
C
EL
I
DY
NG
DA
L
R
E
L
VL
R
Y
AQ
E
W
A
L
PE
AFI
Q
W
L
D
Q
A
N
SF
C
S
T
L
VDRIV
TGYP
R
Y
E
V
A
KL
E
E
E
LG
Y
HD
GFLD
T
A
E
H
F
Y
LF
VI
QGPKSLATELRL
D
KY
-
-
---
-
-
-PL
N
V
L
I
V
D
D
I
K
PY
K
E
R
K
VAI
LNG
A
H
TA
L
VPVAFQ
A
G
LD
T
V
G
E
A
M
N
D
AEI
C
A
FV
EK
AI
Y
EE
II
P
V
L
D
LP
R
-
D
E
L
ES
F
A
SA
VT
G
RF
R
NP
Y
I
KHQ
LLS
IA
LN
G
MT
K
FRTRI
LPQ
-
LLAG
Q
K
-
--
A
NGT
L
P
AR
L
TFAL
A
ALIAF
YR
G
-
E
RN
G
ETYP
V
Q
D
D
A
HW
L
E
R
Y
QQL
W
S
Q
YR
DRVIG
TQ
E
L
V
A
IV
L
A
E
KDH
W
E
Q
DL
T
Q
V
P
G
L
V
E
Q
V
AN
D
L
DA
I
L
E
K
G
M
REAVR
P
LC
fig|585397.7.peg.1667
Escherichia coli ED1a (18-495/495)
RRDFPGAQ
Y
P
E
RI
IQ
FG
E
G
N
F
L
RA
FVDW
Q
I
D
L
L
N
E
H
TD
L
NS
G
VVV
V
R
P
IE
T
S
-
--
F
PPS
L
ST
Q
DG
LYT
T
I
IRGLN
EKG
E
AV
SDA
R
L
I
R
SV
N
REI
S
V
Y
S
E
Y
D
E---
F
L
KLAHN
P
E
M
RF
V
FSN
T
TE
A
G
IS
Y
H
-
A
G
D
K
F
D
-
D
A
P
A
V
S
Y
--
-
--
--
P
A
KL
T
R
L
L
F
E
RF
SH
FNG
A
LD
K
G
WII
I
P
C
EL
I
DY
NG
DA
L
R
E
L
VL
R
Y
AQ
E
W
A
L
PE
AFI
Q
W
L
D
Q
A
N
SF
C
S
T
L
VDRIV
TGYP
R
D
E
V
A
KL
E
E
E
LG
Y
HD
GFLD
T
A
E
H
F
Y
LF
VI
QGPKSLATELRL
D
KY
-
-
---
-
-
-PL
N
V
L
I
V
D
D
I
K
PY
K
E
R
K
VAI
LNG
A
H
TA
L
VPVAFQ
A
G
LD
T
V
G
E
A
M
N
D
AEI
C
A
FV
EK
AI
Y
EE
II
P
V
L
D
LP
R
-
D
E
L
ES
F
A
SA
VT
G
RF
R
NP
Y
I
KHQ
LLS
IA
LN
G
MT
K
FRTRI
LPQ
-
LLAG
Q
K
-
--
A
NGT
L
P
AR
L
TFAL
A
ALIAF
YR
G
-
E
RN
G
ETYP
V
Q
D
D
A
HW
L
E
R
Y
QQL
W
S
Q
YR
DRVIG
TQ
E
L
V
A
IV
L
A
E
KDH
W
E
Q
DL
T
Q
V
P
G
L
V
E
Q
V
AN
D
L
DA
I
L
E
K
G
M
REAVR
P
LC
fig|585397.9.peg.1661
Escherichia coli ED1a (18-495/495)
RRDFPGAQ
Y
P
E
RI
IQ
FG
E
G
N
F
L
RA
FVDW
Q
I
D
L
L
N
E
H
TD
L
NS
G
VVV
V
R
P
IE
T
S
-
--
F
PPS
L
ST
Q
DG
LYT
T
I
IRGLN
EKG
E
AV
SDA
R
L
I
R
SV
N
REI
S
V
Y
S
E
Y
D
E---
F
L
KLAHN
P
E
M
RF
V
FSN
T
TE
A
G
IS
Y
H
-
A
G
D
K
F
D
-
D
A
P
A
V
S
Y
--
-
--
--
P
A
KL
T
R
L
L
F
E
RF
SH
FNG
A
LD
K
G
WII
I
P
C
EL
I
DY
NG
DA
L
R
E
L
VL
R
Y
AQ
E
W
A
L
PE
AFI
Q
W
L
D
Q
A
N
SF
C
S
T
L
VDRIV
TGYP
R
D
E
V
A
KL
E
E
E
LG
Y
HD
GFLD
T
A
E
H
F
Y
LF
VI
QGPKSLATELRL
D
KY
-
-
---
-
-
-PL
N
V
L
I
V
D
D
I
K
PY
K
E
R
K
VAI
LNG
A
H
TA
L
VPVAFQ
A
G
LD
T
V
G
E
A
M
N
D
AEI
C
A
FV
EK
AI
Y
EE
II
P
V
L
D
LP
R
-
D
E
L
ES
F
A
SA
VT
G
RF
R
NP
Y
I
KHQ
LLS
IA
LN
G
MT
K
FRTRI
LPQ
-
LLAG
Q
K
-
--
A
NGT
L
P
AR
L
TFAL
A
ALIAF
YR
G
-
E
RN
G
ETYP
V
Q
D
D
A
HW
L
E
R
Y
QQL
W
S
Q
YR
DRVIG
TQ
E
L
V
A
IV
L
A
E
KDH
W
E
Q
DL
T
Q
V
P
G
L
V
E
Q
V
AN
D
L
DA
I
L
E
K
G
M
REAVR
P
LC
fig|199310.4.peg.1810
Escherichia coli CFT073 (1-480/486)
MKTLNRRDFPGAQ
Y
P
E
RI
IQ
FG
E
G
N
F
L
RA
FVDW
Q
I
D
L
L
N
E
H
T
N
L
NS
G
VVV
V
R
P
IE
T
S
-
--
F
PPS
L
ST
Q
DG
LYT
T
I
IRGLN
EKG
E
AV
SDA
R
L
I
R
SV
N
REI
S
V
Y
S
E
Y
D
E---
F
L
KLAHN
P
E
M
RF
V
FSN
T
TE
A
G
IS
Y
H
-
A
G
D
K
F
D
-
D
A
P
A
V
S
Y
--
-
--
--
P
A
KL
T
R
L
L
F
E
RF
SH
FNG
A
LD
K
G
WII
I
P
C
EL
I
DY
NG
DA
L
R
E
L
VL
R
Y
AQ
E
W
A
L
PE
AFI
Q
W
L
D
Q
A
N
SF
C
S
T
L
VDRIV
TGYP
R
D
E
V
A
KL
E
E
E
LG
Y
HD
GFLD
T
A
E
H
F
Y
LF
VI
QGPKSLATELRL
D
KY
-
-
---
-
-
-PL
N
V
L
I
V
D
D
I
K
PY
K
E
R
K
VAI
LNG
A
H
TA
L
VPVAFQ
A
G
LD
T
V
G
E
A
M
N
D
AEI
C
A
FV
EK
AI
Y
EE
II
P
V
L
D
LP
R
-
D
E
L
ES
F
A
SA
VT
G
RF
R
NP
Y
I
KHQ
LLS
IA
LN
G
MT
K
FRTRI
LPQ
-
LLAG
Q
K
-
--
A
NGT
L
P
AR
L
TFAL
A
ALIAF
YR
G
-
E
RN
G
ETYP
V
Q
D
D
A
HW
L
E
R
Y
QQL
W
S
Q
YR
DRVIG
TQ
E
L
V
A
IV
L
A
E
KDH
W
E
Q
DL
T
Q
V
P
G
L
V
E
Q
V
AN
D
L
DA
I
L
E
K
G
M
REAVR
fig|331112.3.peg.4259
Escherichia coli HS (13-486/486)
R
PSWDHSR
L
E
SRIVH
L
G
C
GAFHRAHQAL
Y
T
H
H
LLE
S
TD
S
DWGICEV
N
L
MP
G
N
D
RV
L
IEN
L
KK
Q
QL
LYTV
A
-----
EKGA
ES
TE
L
K
IIGS
M
K
E
--
A
L
H
P
E
I
D
GCEG
IL
NAMAR
PQ
T
AIVSLT
V
TEKGYC
A
D
A
A
S
G
Q
LD
L
N
NP
L
I
K
HDL
E
NP
TA
P
K
SA
I
G
Y
I
VEAL
RL
RRE
K
GLK
A
FTV
M
SCDN
V
RE
NGHV
A
K
V
AVLG
L
AQ
A
R
D
-
P
Q
-
LA
A
WI
E
E
N
V
T
FP
C
TMVDRIVPAAT
P
E
T
L
Q
EI
A
D
Q
LGV
Y
DPCAI
A
CEPF
R
QWVIE
-----------
DNFV
N
GRP
D
W
DKV
G
A
Q
F
V
A
DV
V
P
F
E
M
MKLRMLNGSHSFLAYLGYL
G
G
YE
TI
A
D
T
M
T
N
PDY
R
K
AA
FS
LM
M
Q
EQAPTL
S
M
P
E
G
T
DL
KA
YA
TL
LI
E
RF
S
NP
S
L
R
H
R
TWQIAMDGSQK
-----
LPQRLL
DP
V
R
L
HL
Q
NG
G
S
W
RH
LALGVAGWMRY
TQ
GVD
EQ
GNAIDV
V
DP
M
--
L
A
E
F
Q
K
I
N
AQ
YQ
-----
GA
D
RV
K
ALL
G
L
SGI
F
A
DDLPQN
A
D
FV
G
AV
TA
A
Y
QQ
L
C
E
R
GARE
C
V
A
AL
fig|331112.6.peg.4432
Escherichia coli HS (13-486/486)
R
PSWDHSR
L
E
SRIVH
L
G
C
GAFHRAHQAL
Y
T
H
H
LLE
S
TD
S
DWGICEV
N
L
MP
G
N
D
RV
L
IEN
L
KK
Q
QL
LYTV
A
-----
EKGA
ES
TE
L
K
IIGS
M
K
E
--
A
L
H
P
E
I
D
GCEG
IL
NAMAR
PQ
T
AIVSLT
V
TEKGYC
A
D
A
A
S
G
Q
LD
L
N
NP
L
I
K
HDL
E
NP
TA
P
K
SA
I
G
Y
I
VEAL
RL
RRE
K
GLK
A
FTV
M
SCDN
V
RE
NGHV
A
K
V
AVLG
L
AQ
A
R
D
-
P
Q
-
LA
A
WI
E
E
N
V
T
FP
C
TMVDRIVPAAT
P
E
T
L
Q
EI
A
D
Q
LGV
Y
DPCAI
A
CEPF
R
QWVIE
-----------
DNFV
N
GRP
D
W
DKV
G
A
Q
F
V
A
DV
V
P
F
E
M
MKLRMLNGSHSFLAYLGYL
G
G
YE
TI
A
D
T
M
T
N
PDY
R
K
AA
FS
LM
M
Q
EQAPTL
S
M
P
E
G
T
DL
KA
YA
TL
LI
E
RF
S
NP
S
L
R
H
R
TWQIAMDGSQK
-----
LPQRLL
DP
V
R
L
HL
Q
NG
G
S
W
RH
LALGVAGWMRY
TQ
GVD
EQ
GNAIDV
V
DP
M
--
L
A
E
F
Q
K
I
N
AQ
YQ
-----
GA
D
RV
K
ALL
G
L
SGI
F
A
DDLPQN
A
D
FV
G
AV
TA
A
Y
QQ
L
C
E
R
GARE
C
V
A
AL
fig|656393.3.peg.518
Escherichia coli H299 (13-486/486)
R
PSWDHSR
L
E
SRIVH
L
G
C
GAFHRAHQAL
Y
T
H
H
LLE
S
TD
S
DWGICEV
N
L
MP
G
N
D
RV
L
IEN
L
KK
Q
QL
LYTV
A
-----
EKGA
ES
TE
L
K
IIGS
M
K
E
--
A
L
H
P
E
I
D
GCEG
IL
NAMAR
PQ
T
AIVSLT
V
TEKGYC
A
D
A
A
S
G
Q
LD
L
N
NP
L
I
K
HDL
E
NP
TA
P
K
SA
I
G
Y
I
VEAL
RL
RRE
K
GLK
A
FTV
M
SCDN
V
RE
NGHV
A
K
V
AVLG
L
AQ
A
R
D
-
P
Q
-
LA
A
WI
E
E
N
V
T
FP
C
TMVDRIVPAAT
P
E
T
L
Q
EI
A
D
Q
LGV
Y
DPCAI
A
CEPF
R
QWVIE
-----------
DNFV
N
GRP
D
W
DKV
G
A
Q
F
V
A
DV
V
P
F
E
M
MKLRMLNGSHSFLAYLGYL
G
G
YE
TI
A
D
T
M
T
N
PDY
R
K
AA
FA
LM
M
Q
EQAPTL
S
M
P
E
G
T
DL
NA
YA
TL
LI
E
RF
S
NP
S
L
R
H
R
TWQIAMDGSQK
-----
LPQRLL
DP
V
R
L
HL
Q
NG
G
S
W
RH
LALGVAGWMRY
TQ
GVD
EQ
G
K
AIDV
V
DP
M
--
L
A
E
F
Q
K
I
N
AQ
YQ
-----
GA
D
RV
K
ALL
G
L
SGI
F
A
DDLPQN
A
D
FV
G
AV
TA
A
Y
QQ
L
C
E
R
GARE
C
V
A
AL
fig|656444.3.peg.208
Escherichia coli TA280 (13-486/486)
R
PSWDHSR
L
E
SRIVH
L
G
C
GAFHRAHQAL
Y
T
H
H
LLE
S
TD
S
DWGICEV
N
L
MP
G
N
D
RV
L
IEN
L
KK
Q
QL
LYTV
A
-----
EKGA
ES
TE
L
K
IIGS
M
K
E
--
A
L
H
P
E
I
D
GCEG
IL
NAMAR
PQ
T
AIVSLT
V
TEKGYC
A
D
A
A
S
G
Q
LD
L
N
NP
L
I
K
HDL
E
NP
TA
P
K
SA
I
G
Y
I
VEAL
RL
RRE
K
GLK
A
FTV
M
SCDN
V
RE
NGHV
A
K
V
AVLG
L
AQ
A
R
D
-
P
Q
-
LA
A
WI
E
E
N
V
T
FP
C
TMVDRIVPAAT
P
E
T
L
Q
EI
A
D
Q
LGV
Y
DPCAI
A
CEPF
R
QWVIE
-----------
DNFV
N
GRP
D
W
DKV
G
A
Q
F
V
A
DV
V
P
F
E
M
MKLRMLNGSHSFLAYLGYL
G
G
YE
TI
A
D
T
M
T
N
PDY
R
K
AA
FA
LM
M
Q
EQAPTL
S
M
P
E
G
T
DL
NA
YA
TL
LI
E
RF
S
NP
S
L
R
H
R
TWQIAMDGSQK
-----
LPQRLL
DP
V
R
L
HL
Q
NG
G
S
W
RH
LALGVAGWMRY
TQ
GVD
EQ
G
K
AIDV
V
DP
M
--
L
A
E
F
Q
K
I
N
AQ
YQ
-----
GA
D
RV
K
ALL
G
L
SGI
F
A
DDLPQN
A
D
FV
G
AV
TA
A
Y
QQ
L
C
E
R
GARE
C
V
A
AL
fig|585396.4.peg.5403
Escherichia coli O111:H- str. 11128 (13-486/486)
R
PSWDHSR
L
E
SRIVH
L
G
C
GAFHRAHQAL
Y
T
H
H
LLE
S
TD
S
DWGICEV
N
L
MP
G
N
D
RV
L
IEN
L
KK
Q
QL
LYTV
A
-----
EKGA
ES
TE
L
K
IIGS
M
K
E
--
A
L
H
P
E
I
D
GCEG
IL
NAMAR
PQ
T
AIVSLT
V
TEKGYC
A
D
A
A
S
G
Q
LD
L
N
NP
L
I
K
HDL
E
NP
TA
P
K
SA
I
G
Y
I
VEAL
RL
RRE
K
GLK
A
FTV
M
SCDN
V
RE
NGHV
A
K
V
AVLG
L
AQ
A
R
D
-
P
Q
-
LA
A
WI
E
E
N
V
T
FP
C
TMVDRIVPAAT
P
E
T
L
Q
EI
A
D
Q
LGV
Y
DPCAI
A
CEPF
R
QWVIE
-----------
DNFV
N
GRP
D
W
DKV
G
A
Q
F
V
A
DV
V
P
F
E
M
MKLRMLNGSHSFLAYLGYL
G
G
YE
TI
A
D
T
M
T
N
PDY
R
K
AA
FS
LM
M
Q
EQAPTL
S
M
P
E
G
T
DL
NA
YA
TL
LI
E
RF
S
NP
S
L
R
H
R
TWQIAMDGSQK
-----
LPQRLL
DP
V
R
L
HL
Q
NG
G
S
W
RH
LALGVAGWMRY
TQ
GVD
EQ
GNAIDV
V
DP
M
--
L
A
E
F
Q
K
I
N
AQ
YQ
-----
GA
D
RV
K
ALL
G
L
SGI
F
A
DDLPQN
A
D
FV
G
AV
TA
A
Y
QQ
L
C
E
R
GARE
C
V
A
AL
fig|1040638.4.peg.732
Escherichia coli O104:H4 str. LB226692 (13-486/486)
R
PSW
E
HSR
L
E
SRIVH
L
G
C
GAFHRAHQAL
Y
T
H
H
LLE
S
TD
S
DWGICEV
N
L
MP
G
N
D
RV
L
IEN
L
KK
Q
QL
LYTV
A
-----
EKGA
ES
TE
L
K
IIGS
M
K
E
--
A
L
H
P
E
I
D
GCEG
IL
NAMAR
PQ
T
AIVSLT
V
TEKGYC
A
D
A
A
S
G
Q
LD
L
N
NP
L
I
K
HDL
E
NP
TA
P
K
SA
I
G
Y
I
VEAL
RL
RRE
K
GLK
A
FTV
M
SCDN
V
RE
NGHV
A
K
V
AVLG
L
AQ
A
R
D
-
P
Q
-
LA
A
WI
E
E
N
V
T
FP
C
TMVDRIVPAAT
P
E
T
L
Q
EI
A
D
Q
LGV
Y
DPCAI
A
CEPF
R
QWVIE
-----------
DNFV
N
GRP
D
W
DKV
G
A
Q
F
V
A
DV
V
P
F
E
M
MKLRMLNGSHSFLAYLGYL
G
G
YE
TI
A
D
T
M
T
N
PDY
R
K
AA
FA
LM
M
Q
EQAPTL
S
M
P
E
G
T
DL
NA
YA
TL
LI
E
RF
S
NP
S
L
R
H
R
TWQIAMDGSQK
-----
LPQRLL
DP
V
R
L
HL
Q
NG
G
S
W
RH
LALGVAGWMRY
TQ
GVD
EQ
GNAIDV
V
DP
M
--
L
A
E
F
Q
K
I
N
AQ
YQ
-----
GA
D
RV
K
ALL
G
L
SGI
F
A
DDLPQN
A
D
FV
G
AV
TA
A
Y
QQ
L
C
E
R
GARE
C
V
A
AL
fig|585055.6.peg.4990
Escherichia coli 55989 (13-486/486)
R
PSW
E
HSR
L
E
SRIVH
L
G
C
GAFHRAHQAL
Y
T
H
H
LLE
S
TD
S
DWGICEV
N
L
MP
G
N
D
RV
L
IEN
L
KK
Q
QL
LYTV
A
-----
EKGA
ES
TE
L
K
IIGS
M
K
E
--
A
L
H
P
E
I
D
GCEG
IL
NAMAR
PQ
T
AIVSLT
V
TEKGYC
A
D
A
A
S
G
Q
LD
L
N
NP
L
I
K
HDL
E
NP
TA
P
K
SA
I
G
Y
I
VEAL
RL
RRE
K
GLK
A
FTV
M
SCDN
V
RE
NGHV
A
K
V
AVLG
L
AQ
A
R
D
-
P
Q
-
LA
A
WI
E
E
N
V
T
FP
C
TMVDRIVPAAT
P
E
T
L
Q
EI
A
D
Q
LGV
Y
DPCAI
A
CEPF
R
QWVIE
-----------
DNFV
N
GRP
D
W
DKV
G
A
Q
F
V
A
DV
V
P
F
E
M
MKLRMLNGSHSFLAYLGYL
G
G
YE
TI
A
D
T
M
T
N
PDY
R
K
AA
FA
LM
M
Q
EQAPTL
S
M
P
E
G
T
DL
NA
YA
TL
LI
E
RF
S
NP
S
L
R
H
R
TWQIAMDGSQK
-----
LPQRLL
DP
V
R
L
HL
Q
NG
G
S
W
RH
LALGVAGWMRY
TQ
GVD
EQ
GNAIDV
V
DP
M
--
L
A
E
F
Q
K
I
N
AQ
YQ
-----
GA
D
RV
K
ALL
G
L
SGI
F
A
DDLPQN
A
D
FV
G
AV
TA
A
Y
QQ
L
C
E
R
GARE
C
V
A
AL
fig|585055.8.peg.4995
Escherichia coli 55989 (13-486/486)
R
PSW
E
HSR
L
E
SRIVH
L
G
C
GAFHRAHQAL
Y
T
H
H
LLE
S
TD
S
DWGICEV
N
L
MP
G
N
D
RV
L
IEN
L
KK
Q
QL
LYTV
A
-----
EKGA
ES
TE
L
K
IIGS
M
K
E
--
A
L
H
P
E
I
D
GCEG
IL
NAMAR
PQ
T
AIVSLT
V
TEKGYC
A
D
A
A
S
G
Q
LD
L
N
NP
L
I
K
HDL
E
NP
TA
P
K
SA
I
G
Y
I
VEAL
RL
RRE
K
GLK
A
FTV
M
SCDN
V
RE
NGHV
A
K
V
AVLG
L
AQ
A
R
D
-
P
Q
-
LA
A
WI
E
E
N
V
T
FP
C
TMVDRIVPAAT
P
E
T
L
Q
EI
A
D
Q
LGV
Y
DPCAI
A
CEPF
R
QWVIE
-----------
DNFV
N
GRP
D
W
DKV
G
A
Q
F
V
A
DV
V
P
F
E
M
MKLRMLNGSHSFLAYLGYL
G
G
YE
TI
A
D
T
M
T
N
PDY
R
K
AA
FA
LM
M
Q
EQAPTL
S
M
P
E
G
T
DL
NA
YA
TL
LI
E
RF
S
NP
S
L
R
H
R
TWQIAMDGSQK
-----
LPQRLL
DP
V
R
L
HL
Q
NG
G
S
W
RH
LALGVAGWMRY
TQ
GVD
EQ
GNAIDV
V
DP
M
--
L
A
E
F
Q
K
I
N
AQ
YQ
-----
GA
D
RV
K
ALL
G
L
SGI
F
A
DDLPQN
A
D
FV
G
AV
TA
A
Y
QQ
L
C
E
R
GARE
C
V
A
AL
fig|749527.3.peg.2979
Escherichia coli MS 21-1 (13-486/486)
R
PSW
E
HSR
L
E
SRIVH
L
G
C
GAFHRAHQAL
Y
T
H
H
LLE
S
TD
S
DWGICEV
N
L
MP
G
N
D
RV
L
IEN
L
KK
Q
QL
LYTV
A
-----
EKGA
ES
TE
L
K
IIGS
M
K
E
--
A
L
H
P
E
I
D
GCEG
IL
NAMAR
PQ
T
AIVSLT
V
TEKGYC
A
D
A
A
S
G
Q
LD
L
N
NP
L
I
K
HDL
E
NP
TA
P
K
SA
I
G
Y
I
VEAL
RL
RRE
K
GLK
A
FTV
M
SCDN
V
RE
NGHV
A
K
V
AVLG
L
AQ
A
R
D
-
P
Q
-
LA
A
WI
E
E
N
V
T
FP
C
TMVDRIVPAAT
P
E
T
L
Q
EI
A
D
Q
LGV
Y
DPCAI
A
CEPF
R
QWVIE
-----------
DNFV
N
GRP
D
W
DKV
G
A
Q
F
V
A
DV
V
P
F
E
M
MKLRMLNGSHSFLAYLGYL
G
G
YE
TI
A
D
T
M
T
N
PDY
R
K
AA
FA
LM
M
Q
EQAPTL
S
M
P
E
G
T
DL
NA
YA
TL
LI
E
RF
S
NP
S
L
R
H
R
TWQIAMDGSQK
-----
LPQRLL
DP
V
R
L
HL
Q
NG
G
S
W
RH
LALGVAGWMRY
TQ
GVD
EQ
GNAIDV
V
DP
M
--
L
A
E
F
Q
K
I
N
AQ
YQ
-----
GA
D
RV
K
ALL
G
L
SGI
F
A
DDLPQN
A
D
FV
G
AV
TA
A
Y
QQ
L
C
E
R
GARE
C
V
A
AL
fig|656437.3.peg.4835
Escherichia coli TA143 (13-486/486)
R
PSW
E
HSR
L
E
SRIVH
L
G
C
GAFHRAHQAL
Y
T
H
H
LLE
S
TD
S
DWGICEV
N
L
MP
G
N
D
RV
L
IEN
L
KK
Q
QL
LYTV
A
-----
EKGA
ES
TE
L
K
IIGS
M
K
E
--
A
L
H
P
E
I
D
GCEG
IL
NAMAR
PQ
T
AIVSLT
V
TEKGYC
A
D
A
A
S
G
Q
LD
L
N
NP
L
I
K
HDL
E
NP
TA
P
K
SA
I
G
Y
I
VEAL
RL
RRE
K
GLK
A
FTV
M
SCDN
V
RE
NGHV
A
K
V
AVLG
L
AQ
A
R
D
-
P
Q
-
LA
A
WI
E
E
N
V
T
FP
C
TMVDRIVPAAT
P
E
T
L
Q
EI
A
D
Q
LGV
Y
DPCAI
A
CEPF
R
QWVIE
-----------
DNFV
N
GRP
D
W
DKV
G
A
Q
F
V
A
DV
V
P
F
E
M
MKLRMLNGSHSFLAYLGYL
G
G
YE
TI
A
D
T
M
T
N
PDY
R
K
AA
FA
LM
M
Q
EQAPTL
S
M
P
E
G
T
DL
NA
YA
TL
LI
E
RF
S
NP
S
L
R
H
R
TWQIAMDGSQK
-----
LPQRLL
DP
V
R
L
HL
Q
NG
G
S
W
RH
LALGVAGWMRY
TQ
GVD
EQ
GNAIDV
V
DP
M
--
L
A
E
F
Q
K
I
N
AQ
YQ
-----
GA
D
RV
K
ALL
G
L
SGI
F
A
DDLPQN
A
D
FV
G
AV
TA
A
Y
QQ
L
C
E
R
GARE
C
V
A
AL
fig|344610.3.peg.653
Escherichia coli 53638 (13-486/486)
R
PSW
E
HSR
L
E
SRIVH
L
G
C
GAFHRAHQAL
Y
T
H
H
LLE
S
TD
S
DWGICEV
N
L
MP
G
N
D
RV
L
IEN
L
KK
Q
QL
LYTV
A
-----
EKGA
ES
TE
L
K
IIGS
M
K
E
--
A
L
H
P
E
I
D
GCEG
IL
NAMAR
PQ
T
AIVSLT
V
TEKGYC
A
D
A
A
S
G
Q
LD
L
N
NP
L
I
K
HDL
E
NP
TA
P
K
SA
I
G
Y
I
VEAL
RL
RRE
K
GLK
A
FTV
M
SCDN
V
RE
NGHV
A
K
V
AVLG
L
AQ
A
R
D
-
P
Q
-
LA
A
WI
E
E
N
V
T
FP
C
TMVDRIVPAAT
P
E
T
L
Q
EI
A
D
Q
LGV
Y
DPCAI
A
CEPF
R
QWVIE
-----------
DNFV
N
GRP
D
W
DKV
G
A
Q
F
V
A
DV
V
P
F
E
M
MKLRMLNGSHSFLAYLGYL
G
G
YE
TI
A
D
T
M
T
N
PDY
R
K
AA
FS
LM
M
Q
EQAPTL
S
M
P
E
G
T
DL
NA
YA
TL
LI
E
RF
S
NP
S
L
R
H
R
TWQIAMDGSQK
-----
LPQRLL
DP
V
R
L
HL
Q
NG
G
S
W
RH
LALGVAGWMRY
TQ
GVD
EQ
GNAIDV
V
DP
M
--
L
A
E
F
Q
KV
N
AQ
YQ
-----
GA
D
RV
K
ALL
G
L
SGI
F
A
DDLPQN
A
D
FV
G
AV
TA
A
Y
QQ
L
C
E
R
GARE
C
V
A
AL
fig|344610.7.peg.1843
Escherichia coli 53638 (13-486/486)
R
PSW
E
HSR
L
E
SRIVH
L
G
C
GAFHRAHQAL
Y
T
H
H
LLE
S
TD
S
DWGICEV
N
L
MP
G
N
D
RV
L
IEN
L
KK
Q
QL
LYTV
A
-----
EKGA
ES
TE
L
K
IIGS
M
K
E
--
A
L
H
P
E
I
D
GCEG
IL
NAMAR
PQ
T
AIVSLT
V
TEKGYC
A
D
A
A
S
G
Q
LD
L
N
NP
L
I
K
HDL
E
NP
TA
P
K
SA
I
G
Y
I
VEAL
RL
RRE
K
GLK
A
FTV
M
SCDN
V
RE
NGHV
A
K
V
AVLG
L
AQ
A
R
D
-
P
Q
-
LA
A
WI
E
E
N
V
T
FP
C
TMVDRIVPAAT
P
E
T
L
Q
EI
A
D
Q
LGV
Y
DPCAI
A
CEPF
R
QWVIE
-----------
DNFV
N
GRP
D
W
DKV
G
A
Q
F
V
A
DV
V
P
F
E
M
MKLRMLNGSHSFLAYLGYL
G
G
YE
TI
A
D
T
M
T
N
PDY
R
K
AA
FS
LM
M
Q
EQAPTL
S
M
P
E
G
T
DL
NA
YA
TL
LI
E
RF
S
NP
S
L
R
H
R
TWQIAMDGSQK
-----
LPQRLL
DP
V
R
L
HL
Q
NG
G
S
W
RH
LALGVAGWMRY
TQ
GVD
EQ
GNAIDV
V
DP
M
--
L
A
E
F
Q
KV
N
AQ
YQ
-----
GA
D
RV
K
ALL
G
L
SGI
F
A
DDLPQN
A
D
FV
G
AV
TA
A
Y
QQ
L
C
E
R
GARE
C
V
A
AL
fig|358709.5.peg.2342
Escherichia coli 101-1 (13-486/486)
R
PSWDHSR
L
E
SRIVH
L
G
C
GAFHRAHQAL
Y
T
H
H
LLE
S
TD
S
DWGICEV
N
L
MP
G
N
D
RV
L
IEN
L
KK
Q
QL
LYTV
A
-----
EKGA
ES
TE
L
K
IIGS
M
K
E
--
A
L
H
P
E
I
D
GCEG
IL
NAMAR
PQ
T
AIVSLT
V
TEKGYC
A
D
A
A
S
G
Q
LD
L
N
NP
L
I
K
HDL
E
NP
TA
P
K
SA
I
G
Y
I
VEAL
RL
RRE
K
GLK
A
FTV
M
SCDN
V
RE
NGHV
A
K
V
AVLG
L
AQ
A
R
D
-
P
Q
-
LA
A
WI
E
E
N
V
T
FP
C
TMVDRIVPAAT
P
E
T
L
Q
EI
A
D
Q
LGV
Y
DPCAI
A
CEPF
R
QWVIE
-----------
DNFV
N
GRP
D
W
DKV
G
A
Q
F
V
A
DV
V
P
F
E
M
MKLRMLNGSHSFLAYLGYL
G
G
YE
TI
A
D
T
M
T
N
PDY
R
K
AA
FA
LM
M
Q
EQAPTL
S
M
P
E
G
T
DL
NA
YA
TL
LI
E
RF
S
NP
S
L
R
H
R
TWQIAMDGSQK
-----
LPQRLL
DP
V
R
L
HL
Q
NG
G
S
W
RH
LALGVAGWMRY
TQ
GVD
EQ
GNAIDV
V
DP
M
--
L
A
E
F
Q
K
I
N
AQ
YQ
-----
GA
D
RV
K
ALL
G
L
SGI
F
A
DDLPQN
A
D
FV
G
AV
TA
A
Y
QQ
L
C
E
R
GARE
C
V
A
AL
fig|562.371.peg.3838
Escherichia coli 1044A (13-486/486)
R
PSWDHSR
L
E
SRIVH
L
G
C
GAFHRAHQAL
Y
T
H
H
LLE
S
TD
S
DWGICEV
N
L
MP
G
N
D
RV
L
IEN
L
KK
Q
QL
LYTV
A
-----
EKGA
ES
TE
L
K
IIGS
M
K
E
--
A
L
H
P
E
I
D
GCEG
IL
NAMAR
PQ
T
AIVSLT
V
TEKGYC
A
D
A
A
S
G
Q
LD
L
N
NP
L
I
K
HDL
E
NP
TA
P
K
SA
I
G
Y
I
VEAL
RL
RRE
K
GLK
A
FTV
M
SCDN
V
RE
NGHV
A
K
V
AVLG
L
AQ
A
R
D
-
P
Q
-
LA
A
WI
E
E
N
V
T
FP
C
TMVDRIVPAAT
P
E
T
L
Q
EI
A
D
Q
LGV
Y
DPCAI
A
CEPF
R
QWVIE
-----------
DNFV
N
GRP
D
W
DKV
G
A
Q
F
V
A
DV
V
P
F
E
M
MKLRMLNGSHSFLAYLGYL
G
G
YE
TI
A
D
T
M
T
N
PDY
R
K
AA
FA
LM
M
Q
EQAPTL
S
M
P
E
G
T
DL
NA
YA
TL
LI
E
RF
S
NP
S
L
R
H
R
TWQIAMDGSQK
-----
LPQRLL
DP
V
R
L
HL
Q
NG
G
S
W
RH
LALGVAGWMRY
TQ
GVD
EQ
GNAIDV
V
DP
M
--
L
A
E
F
Q
K
I
N
AQ
YQ
-----
GA
D
RV
K
ALL
G
L
SGI
F
A
DDLPQN
A
D
FV
G
AV
TA
A
Y
QQ
L
C
E
R
GARE
C
V
A
AL
fig|562.373.peg.2365
Escherichia coli 1125A (13-486/486)
R
PSWDHSR
L
E
SRIVH
L
G
C
GAFHRAHQAL
Y
T
H
H
LLE
S
TD
S
DWGICEV
N
L
MP
G
N
D
RV
L
IEN
L
KK
Q
QL
LYTV
A
-----
EKGA
ES
TE
L
K
IIGS
M
K
E
--
A
L
H
P
E
I
D
GCEG
IL
NAMAR
PQ
T
AIVSLT
V
TEKGYC
A
D
A
A
S
G
Q
LD
L
N
NP
L
I
K
HDL
E
NP
TA
P
K
SA
I
G
Y
I
VEAL
RL
RRE
K
GLK
A
FTV
M
SCDN
V
RE
NGHV
A
K
V
AVLG
L
AQ
A
R
D
-
P
Q
-
LA
A
WI
E
E
N
V
T
FP
C
TMVDRIVPAAT
P
E
T
L
Q
EI
A
D
Q
LGV
Y
DPCAI
A
CEPF
R
QWVIE
-----------
DNFV
N
GRP
D
W
DKV
G
A
Q
F
V
A
DV
V
P
F
E
M
MKLRMLNGSHSFLAYLGYL
G
G
YE
TI
A
D
T
M
T
N
PDY
R
K
AA
FA
LM
M
Q
EQAPTL
S
M
P
E
G
T
DL
NA
YA
TL
LI
E
RF
S
NP
S
L
R
H
R
TWQIAMDGSQK
-----
LPQRLL
DP
V
R
L
HL
Q
NG
G
S
W
RH
LALGVAGWMRY
TQ
GVD
EQ
GNAIDV
V
DP
M
--
L
A
E
F
Q
K
I
N
AQ
YQ
-----
GA
D
RV
K
ALL
G
L
SGI
F
A
DDLPQN
A
D
FV
G
AV
TA
A
Y
QQ
L
C
E
R
GARE
C
V
A
AL
fig|562.372.peg.3218
Escherichia coli 1212A (13-486/486)
R
PSWDHSR
L
E
SRIVH
L
G
C
GAFHRAHQAL
Y
T
H
H
LLE
S
TD
S
DWGICEV
N
L
MP
G
N
D
RV
L
IEN
L
KK
Q
QL
LYTV
A
-----
EKGA
ES
TE
L
K
IIGS
M
K
E
--
A
L
H
P
E
I
D
GCEG
IL
NAMAR
PQ
T
AIVSLT
V
TEKGYC
A
D
A
A
S
G
Q
LD
L
N
NP
L
I
K
HDL
E
NP
TA
P
K
SA
I
G
Y
I
VEAL
RL
RRE
K
GLK
A
FTV
M
SCDN
V
RE
NGHV
A
K
V
AVLG
L
AQ
A
R
D
-
P
Q
-
LA
A
WI
E
E
N
V
T
FP
C
TMVDRIVPAAT
P
E
T
L
Q
EI
A
D
Q
LGV
Y
DPCAI
A
CEPF
R
QWVIE
-----------
DNFV
N
GRP
D
W
DKV
G
A
Q
F
V
A
DV
V
P
F
E
M
MKLRMLNGSHSFLAYLGYL
G
G
YE
TI
A
D
T
M
T
N
PDY
R
K
AA
FA
LM
M
Q
EQAPTL
S
M
P
E
G
T
DL
NA
YA
TL
LI
E
RF
S
NP
S
L
R
H
R
TWQIAMDGSQK
-----
LPQRLL
DP
V
R
L
HL
Q
NG
G
S
W
RH
LALGVAGWMRY
TQ
GVD
EQ
GNAIDV
V
DP
M
--
L
A
E
F
Q
K
I
N
AQ
YQ
-----
GA
D
RV
K
ALL
G
L
SGI
F
A
DDLPQN
A
D
FV
G
AV
TA
A
Y
QQ
L
C
E
R
GARE
C
V
A
AL
fig|670897.3.peg.1734
Escherichia coli 2362-75 (13-486/486)
R
PSWDHSR
L
E
SRIVH
L
G
C
GAFHRAHQAL
Y
T
H
H
LLE
S
TD
S
DWGICEV
N
L
MP
G
N
D
RV
L
IEN
L
KK
Q
QL
LYTV
A
-----
EKGA
ES
TE
L
K
IIGS
M
K
E
--
A
L
H
P
E
I
D
GCEG
IL
NAMAR
PQ
T
AIVSLT
V
TEKGYC
A
D
A
A
S
G
Q
LD
L
N
NP
L
I
K
HDL
E
NP
TA
P
K
SA
I
G
Y
I
VEAL
RL
RRE
K
GLK
A
FTV
M
SCDN
V
RE
NGHV
A
K
V
AVLG
L
AQ
A
R
D
-
P
Q
-
LA
A
WI
E
E
N
V
T
FP
C
TMVDRIVPAAT
P
E
T
L
Q
EI
A
D
Q
LGV
Y
DPCAI
A
CEPF
R
QWVIE
-----------
DNFV
N
GRP
D
W
DKV
G
A
Q
F
V
A
DV
V
P
F
E
M
MKLRMLNGSHSFLAYLGYL
G
G
YE
TI
A
D
T
M
T
N
PDY
R
K
AA
FA
LM
M
Q
EQAPTL
S
M
P
E
G
T
DL
NA
YA
TL
LI
E
RF
S
NP
S
L
R
H
R
TWQIAMDGSQK
-----
LPQRLL
DP
V
R
L
HL
Q
NG
G
S
W
RH
LALGVAGWMRY
TQ
GVD
EQ
GNAIDV
V
DP
M
--
L
A
E
F
Q
K
I
N
AQ
YQ
-----
GA
D
RV
K
ALL
G
L
SGI
F
A
DDLPQN
A
D
FV
G
AV
TA
A
Y
QQ
L
C
E
R
GARE
C
V
A
AL
fig|562.374.peg.2990
Escherichia coli 536A (13-486/486)
R
PSWDHSR
L
E
SRIVH
L
G
C
GAFHRAHQAL
Y
T
H
H
LLE
S
TD
S
DWGICEV
N
L
MP
G
N
D
RV
L
IEN
L
KK
Q
QL
LYTV
A
-----
EKGA
ES
TE
L
K
IIGS
M
K
E
--
A
L
H
P
E
I
D
GCEG
IL
NAMAR
PQ
T
AIVSLT
V
TEKGYC
A
D
A
A
S
G
Q
LD
L
N
NP
L
I
K
HDL
E
NP
TA
P
K
SA
I
G
Y
I
VEAL
RL
RRE
K
GLK
A
FTV
M
SCDN
V
RE
NGHV
A
K
V
AVLG
L
AQ
A
R
D
-
P
Q
-
LA
A
WI
E
E
N
V
T
FP
C
TMVDRIVPAAT
P
E
T
L
Q
EI
A
D
Q
LGV
Y
DPCAI
A
CEPF
R
QWVIE
-----------
DNFV
N
GRP
D
W
DKV
G
A
Q
F
V
A
DV
V
P
F
E
M
MKLRMLNGSHSFLAYLGYL
G
G
YE
TI
A
D
T
M
T
N
PDY
R
K
AA
FA
LM
M
Q
EQAPTL
S
M
P
E
G
T
DL
NA
YA
TL
LI
E
RF
S
NP
S
L
R
H
R
TWQIAMDGSQK
-----
LPQRLL
DP
V
R
L
HL
Q
NG
G
S
W
RH
LALGVAGWMRY
TQ
GVD
EQ
GNAIDV
V
DP
M
--
L
A
E
F
Q
K
I
N
AQ
YQ
-----
GA
D
RV
K
ALL
G
L
SGI
F
A
DDLPQN
A
D
FV
G
AV
TA
A
Y
QQ
L
C
E
R
GARE
C
V
A
AL
fig|344601.3.peg.791
Escherichia coli B171 (13-486/486)
R
PSWDHSR
L
E
SRIVH
L
G
C
GAFHRAHQAL
Y
T
H
H
LLE
S
TD
S
DWGICEV
N
L
MP
G
N
D
RV
L
IEN
L
KK
Q
QL
LYTV
A
-----
EKGA
ES
TE
L
K
IIGS
M
K
E
--
A
L
H
P
E
I
D
GCEG
IL
NAMAR
PQ
T
AIVSLT
V
TEKGYC
A
D
A
A
S
G
Q
LD
L
N
NP
L
I
K
HDL
E
NP
TA
P
K
SA
I
G
Y
I
VEAL
RL
RRE
K
GLK
A
FTV
M
SCDN
V
RE
NGHV
A
K
V
AVLG
L
AQ
A
R
D
-
P
Q
-
LA
A
WI
E
E
N
V
T
FP
C
TMVDRIVPAAT
P
E
T
L
Q
EI
A
D
Q
LGV
Y
DPCAI
A
CEPF
R
QWVIE
-----------
DNFV
N
GRP
D
W
DKV
G
A
Q
F
V
A
DV
V
P
F
E
M
MKLRMLNGSHSFLAYLGYL
G
G
YE
TI
A
D
T
M
T
N
PDY
R
K
AA
FA
LM
M
Q
EQAPTL
S
M
P
E
G
T
DL
NA
YA
TL
LI
E
RF
S
NP
S
L
R
H
R
TWQIAMDGSQK
-----
LPQRLL
DP
V
R
L
HL
Q
NG
G
S
W
RH
LALGVAGWMRY
TQ
GVD
EQ
GNAIDV
V
DP
M
--
L
A
E
F
Q
K
I
N
AQ
YQ
-----
GA
D
RV
K
ALL
G
L
SGI
F
A
DDLPQN
A
D
FV
G
AV
TA
A
Y
QQ
L
C
E
R
GARE
C
V
A
AL
fig|344601.5.peg.823
Escherichia coli B171 (13-486/486)
R
PSWDHSR
L
E
SRIVH
L
G
C
GAFHRAHQAL
Y
T
H
H
LLE
S
TD
S
DWGICEV
N
L
MP
G
N
D
RV
L
IEN
L
KK
Q
QL
LYTV
A
-----
EKGA
ES
TE
L
K
IIGS
M
K
E
--
A
L
H
P
E
I
D
GCEG
IL
NAMAR
PQ
T
AIVSLT
V
TEKGYC
A
D
A
A
S
G
Q
LD
L
N
NP
L
I
K
HDL
E
NP
TA
P
K
SA
I
G
Y
I
VEAL
RL
RRE
K
GLK
A
FTV
M
SCDN
V
RE
NGHV
A
K
V
AVLG
L
AQ
A
R
D
-
P
Q
-
LA
A
WI
E
E
N
V
T
FP
C
TMVDRIVPAAT
P
E
T
L
Q
EI
A
D
Q
LGV
Y
DPCAI
A
CEPF
R
QWVIE
-----------
DNFV
N
GRP
D
W
DKV
G
A
Q
F
V
A
DV
V
P
F
E
M
MKLRMLNGSHSFLAYLGYL
G
G
YE
TI
A
D
T
M
T
N
PDY
R
K
AA
FA
LM
M
Q
EQAPTL
S
M
P
E
G
T
DL
NA
YA
TL
LI
E
RF
S
NP
S
L
R
H
R
TWQIAMDGSQK
-----
LPQRLL
DP
V
R
L
HL
Q
NG
G
S
W
RH
LALGVAGWMRY
TQ
GVD
EQ
GNAIDV
V
DP
M
--
L
A
E
F
Q
K
I
N
AQ
YQ
-----
GA
D
RV
K
ALL
G
L
SGI
F
A
DDLPQN
A
D
FV
G
AV
TA
A
Y
QQ
L
C
E
R
GARE
C
V
A
AL
fig|550676.3.peg.4565
Escherichia coli B185 (13-486/486)
R
PSWDHSR
L
E
SRIVH
L
G
C
GAFHRAHQAL
Y
T
H
H
LLE
S
TD
S
DWGICEV
N
L
MP
G
N
D
RV
L
IEN
L
KK
Q
QL
LYTV
A
-----
EKGA
ES
TE
L
K
IIGS
M
K
E
--
A
L
H
P
E
I
D
GCEG
IL
NAMAR
PQ
T
AIVSLT
V
TEKGYC
A
D
A
A
S
G
Q
LD
L
N
NP
L
I
K
HDL
E
NP
TA
P
K
SA
I
G
Y
I
VEAL
RL
RRE
K
GLK
A
FTV
M
SCDN
V
RE
NGHV
A
K
V
AVLG
L
AQ
A
R
D
-
P
Q
-
LA
A
WI
E
E
N
V
T
FP
C
TMVDRIVPAAT
P
E
T
L
Q
EI
A
D
Q
LGV
Y
DPCAI
A
CEPF
R
QWVIE
-----------
DNFV
N
GRP
D
W
DKV
G
A
Q
F
V
A
DV
V
P
F
E
M
MKLRMLNGSHSFLAYLGYL
G
G
YE
TI
A
D
T
M
T
N
PDY
R
K
AA
FA
LM
M
Q
EQAPTL
S
M
P
E
G
T
DL
NA
YA
TL
LI
E
RF
S
NP
S
L
R
H
R
TWQIAMDGSQK
-----
LPQRLL
DP
V
R
L
HL
Q
NG
G
S
W
RH
LALGVAGWMRY
TQ
GVD
EQ
GNAIDV
V
DP
M
--
L
A
E
F
Q
K
I
N
AQ
YQ
-----
GA
D
RV
K
ALL
G
L
SGI
F
A
DDLPQN
A
D
FV
G
AV
TA
A
Y
QQ
L
C
E
R
GARE
C
V
A
AL
fig|550677.3.peg.291
Escherichia coli B354 (13-486/486)
R
PSWDHSR
L
E
SRIVH
L
G
C
GAFHRAHQAL
Y
T
H
H
LLE
S
TD
S
DWGICEV
N
L
MP
G
N
D
RV
L
IEN
L
KK
Q
QL
LYTV
A
-----
EKGA
ES
TE
L
K
IIGS
M
K
E
--
A
L
H
P
E
I
D
GCEG
IL
NAMAR
PQ
T
AIVSLT
V
TEKGYC
A
D
A
A
S
G
Q
LD
L
N
NP
L
I
K
HDL
E
NP
TA
P
K
SA
I
G
Y
I
VEAL
RL
RRE
K
GLK
A
FTV
M
SCDN
V
RE
NGHV
A
K
V
AVLG
L
AQ
A
R
D
-
P
Q
-
LA
A
WI
E
E
N
V
T
FP
C
TMVDRIVPAAT
P
E
T
L
Q
EI
A
D
Q
LGV
Y
DPCAI
A
CEPF
R
QWVIE
-----------
DNFV
N
GRP
D
W
DKV
G
A
Q
F
V
A
DV
V
P
F
E
M
MKLRMLNGSHSFLAYLGYL
G
G
YE
TI
A
D
T
M
T
N
PDY
R
K
AA
FA
LM
M
Q
EQAPTL
S
M
P
E
G
T
DL
NA
YA
TL
LI
E
RF
S
NP
S
L
R
H
R
TWQIAMDGSQK
-----
LPQRLL
DP
V
R
L
HL
Q
NG
G
S
W
RH
LALGVAGWMRY
TQ
GVD
EQ
GNAIDV
V
DP
M
--
L
A
E
F
Q
K
I
N
AQ
YQ
-----
GA
D
RV
K
ALL
G
L
SGI
F
A
DDLPQN
A
D
FV
G
AV
TA
A
Y
QQ
L
C
E
R
GARE
C
V
A
AL
fig|340184.3.peg.2252
Escherichia coli B7A (13-486/486)
R
PSWDHSR
L
E
SRIVH
L
G
C
GAFHRAHQAL
Y
T
H
H
LLE
S
TD
S
DWGICEV
N
L
MP
G
N
D
RV
L
IEN
L
KK
Q
QL
LYTV
A
-----
EKGA
ES
TE
L
K
IIGS
M
K
E
--
A
L
H
P
E
I
D
GCEG
IL
NAMAR
PQ
T
AIVSLT
V
TEKGYC
A
D
A
A
S
G
Q
LD
L
N
NP
L
I
K
HDL
E
NP
TA
P
K
SA
I
G
Y
I
VEAL
RL
RRE
K
GLK
A
FTV
M
SCDN
V
RE
NGHV
A
K
V
AVLG
L
AQ
A
R
D
-
P
Q
-
LA
A
WI
E
E
N
V
T
FP
C
TMVDRIVPAAT
P
E
T
L
Q
EI
A
D
Q
LGV
Y
DPCAI
A
CEPF
R
QWVIE
-----------
DNFV
N
GRP
D
W
DKV
G
A
Q
F
V
A
DV
V
P
F
E
M
MKLRMLNGSHSFLAYLGYL
G
G
YE
TI
A
D
T
M
T
N
PDY
R
K
AA
FA
LM
M
Q
EQAPTL
S
M
P
E
G
T
DL
NA
YA
TL
LI
E
RF
S
NP
S
L
R
H
R
TWQIAMDGSQK
-----
LPQRLL
DP
V
R
L
HL
Q
NG
G
S
W
RH
LALGVAGWMRY
TQ
GVD
EQ
GNAIDV
V
DP
M
--
L
A
E
F
Q
K
I
N
AQ
YQ
-----
GA
D
RV
K
ALL
G
L
SGI
F
A
DDLPQN
A
D
FV
G
AV
TA
A
Y
QQ
L
C
E
R
GARE
C
V
A
AL
fig|340184.6.peg.2363
Escherichia coli B7A (13-486/486)
R
PSWDHSR
L
E
SRIVH
L
G
C
GAFHRAHQAL
Y
T
H
H
LLE
S
TD
S
DWGICEV
N
L
MP
G
N
D
RV
L
IEN
L
KK
Q
QL
LYTV
A
-----
EKGA
ES
TE
L
K
IIGS
M
K
E
--
A
L
H
P
E
I
D
GCEG
IL
NAMAR
PQ
T
AIVSLT
V
TEKGYC
A
D
A
A
S
G
Q
LD
L
N
NP
L
I
K
HDL
E
NP
TA
P
K
SA
I
G
Y
I
VEAL
RL
RRE
K
GLK
A
FTV
M
SCDN
V
RE
NGHV
A
K
V
AVLG
L
AQ
A
R
D
-
P
Q
-
LA
A
WI
E
E
N
V
T
FP
C
TMVDRIVPAAT
P
E
T
L
Q
EI
A
D
Q
LGV
Y
DPCAI
A
CEPF
R
QWVIE
-----------
DNFV
N
GRP
D
W
DKV
G
A
Q
F
V
A
DV
V
P
F
E
M
MKLRMLNGSHSFLAYLGYL
G
G
YE
TI
A
D
T
M
T
N
PDY
R
K
AA
FA
LM
M
Q
EQAPTL
S
M
P
E
G
T
DL
NA
YA
TL
LI
E
RF
S
NP
S
L
R
H
R
TWQIAMDGSQK
-----
LPQRLL
DP
V
R
L
HL
Q
NG
G
S
W
RH
LALGVAGWMRY
TQ
GVD
EQ
GNAIDV
V
DP
M
--
L
A
E
F
Q
K
I
N
AQ
YQ
-----
GA
D
RV
K
ALL
G
L
SGI
F
A
DDLPQN
A
D
FV
G
AV
TA
A
Y
QQ
L
C
E
R
GARE
C
V
A
AL
fig|656408.3.peg.4802
Escherichia coli H591 (13-486/486)
R
PSWDHSR
L
E
SRIVH
L
G
C
GAFHRAHQAL
Y
T
H
H
LLE
S
TD
S
DWGICEV
N
L
MP
G
N
D
RV
L
IEN
L
KK
Q
QL
LYTV
A
-----
EKGA
ES
TE
L
K
IIGS
M
K
E
--
A
L
H
P
E
I
D
GCEG
IL
NAMAR
PQ
T
AIVSLT
V
TEKGYC
A
D
A
A
S
G
Q
LD
L
N
NP
L
I
K
HDL
E
NP
TA
P
K
SA
I
G
Y
I
VEAL
RL
RRE
K
GLK
A
FTV
M
SCDN
V
RE
NGHV
A
K
V
AVLG
L
AQ
A
R
D
-
P
Q
-
LA
A
WI
E
E
N
V
T
FP
C
TMVDRIVPAAT
P
E
T
L
Q
EI
A
D
Q
LGV
Y
DPCAI
A
CEPF
R
QWVIE
-----------
DNFV
N
GRP
D
W
DKV
G
A
Q
F
V
A
DV
V
P
F
E
M
MKLRMLNGSHSFLAYLGYL
G
G
YE
TI
A
D
T
M
T
N
PDY
R
K
AA
FA
LM
M
Q
EQAPTL
S
M
P
E
G
T
DL
NA
YA
TL
LI
E
RF
S
NP
S
L
R
H
R
TWQIAMDGSQK
-----
LPQRLL
DP
V
R
L
HL
Q
NG
G
S
W
RH
LALGVAGWMRY
TQ
GVD
EQ
GNAIDV
V
DP
M
--
L
A
E
F
Q
K
I
N
AQ
YQ
-----
GA
D
RV
K
ALL
G
L
SGI
F
A
DDLPQN
A
D
FV
G
AV
TA
A
Y
QQ
L
C
E
R
GARE
C
V
A
AL
fig|656414.3.peg.28
Escherichia coli H736 (13-486/486)
R
PSWDHSR
L
E
SRIVH
L
G
C
GAFHRAHQAL
Y
T
H
H
LLE
S
TD
S
DWGICEV
N
L
MP
G
N
D
RV
L
IEN
L
KK
Q
QL
LYTV
A
-----
EKGA
ES
TE
L
K
IIGS
M
K
E
--
A
L
H
P
E
I
D
GCEG
IL
NAMAR
PQ
T
AIVSLT
V
TEKGYC
A
D
A
A
S
G
Q
LD
L
N
NP
L
I
K
HDL
E
NP
TA
P
K
SA
I
G
Y
I
VEAL
RL
RRE
K
GLK
A
FTV
M
SCDN
V
RE
NGHV
A
K
V
AVLG
L
AQ
A
R
D
-
P
Q
-
LA
A
WI
E
E
N
V
T
FP
C
TMVDRIVPAAT
P
E
T
L
Q
EI
A
D
Q
LGV
Y
DPCAI
A
CEPF
R
QWVIE
-----------
DNFV
N
GRP
D
W
DKV
G
A
Q
F
V
A
DV
V
P
F
E
M
MKLRMLNGSHSFLAYLGYL
G
G
YE
TI
A
D
T
M
T
N
PDY
R
K
AA
FA
LM
M
Q
EQAPTL
S
M
P
E
G
T
DL
NA
YA
TL
LI
E
RF
S
NP
S
L
R
H
R
TWQIAMDGSQK
-----
LPQRLL
DP
V
R
L
HL
Q
NG
G
S
W
RH
LALGVAGWMRY
TQ
GVD
EQ
GNAIDV
V
DP
M
--
L
A
E
F
Q
K
I
N
AQ
YQ
-----
GA
D
RV
K
ALL
G
L
SGI
F
A
DDLPQN
A
D
FV
G
AV
TA
A
Y
QQ
L
C
E
R
GARE
C
V
A
AL
fig|679207.4.peg.3433
Escherichia coli MS 107-1 (13-486/486)
R
PSWDHSR
L
E
SRIVH
L
G
C
GAFHRAHQAL
Y
T
H
H
LLE
S
TD
S
DWGICEV
N
L
MP
G
N
D
RV
L
IEN
L
KK
Q
QL
LYTV
A
-----
EKGA
ES
TE
L
K
IIGS
M
K
E
--
A
L
H
P
E
I
D
GCEG
IL
NAMAR
PQ
T
AIVSLT
V
TEKGYC
A
D
A
A
S
G
Q
LD
L
N
NP
L
I
K
HDL
E
NP
TA
P
K
SA
I
G
Y
I
VEAL
RL
RRE
K
GLK
A
FTV
M
SCDN
V
RE
NGHV
A
K
V
AVLG
L
AQ
A
R
D
-
P
Q
-
LA
A
WI
E
E
N
V
T
FP
C
TMVDRIVPAAT
P
E
T
L
Q
EI
A
D
Q
LGV
Y
DPCAI
A
CEPF
R
QWVIE
-----------
DNFV
N
GRP
D
W
DKV
G
A
Q
F
V
A
DV
V
P
F
E
M
MKLRMLNGSHSFLAYLGYL
G
G
YE
TI
A
D
T
M
T
N
PDY
R
K
AA
FA
LM
M
Q
EQAPTL
S
M
P
E
G
T
DL
NA
YA
TL
LI
E
RF
S
NP
S
L
R
H
R
TWQIAMDGSQK
-----
LPQRLL
DP
V
R
L
HL
Q
NG
G
S
W
RH
LALGVAGWMRY
TQ
GVD
EQ
GNAIDV
V
DP
M
--
L
A
E
F
Q
K
I
N
AQ
YQ
-----
GA
D
RV
K
ALL
G
L
SGI
F
A
DDLPQN
A
D
FV
G
AV
TA
A
Y
QQ
L
C
E
R
GARE
C
V
A
AL
fig|679206.4.peg.3542
Escherichia coli MS 119-7 (13-486/486)
R
PSWDHSR
L
E
SRIVH
L
G
C
GAFHRAHQAL
Y
T
H
H
LLE
S
TD
S
DWGICEV
N
L
MP
G
N
D
RV
L
IEN
L
KK
Q
QL
LYTV
A
-----
EKGA
ES
TE
L
K
IIGS
M
K
E
--
A
L
H
P
E
I
D
GCEG
IL
NAMAR
PQ
T
AIVSLT
V
TEKGYC
A
D
A
A
S
G
Q
LD
L
N
NP
L
I
K
HDL
E
NP
TA
P
K
SA
I
G
Y
I
VEAL
RL
RRE
K
GLK
A
FTV
M
SCDN
V
RE
NGHV
A
K
V
AVLG
L
AQ
A
R
D
-
P
Q
-
LA
A
WI
E
E
N
V
T
FP
C
TMVDRIVPAAT
P
E
T
L
Q
EI
A
D
Q
LGV
Y
DPCAI
A
CEPF
R
QWVIE
-----------
DNFV
N
GRP
D
W
DKV
G
A
Q
F
V
A
DV
V
P
F
E
M
MKLRMLNGSHSFLAYLGYL
G
G
YE
TI
A
D
T
M
T
N
PDY
R
K
AA
FA
LM
M
Q
EQAPTL
S
M
P
E
G
T
DL
NA
YA
TL
LI
E
RF
S
NP
S
L
R
H
R
TWQIAMDGSQK
-----
LPQRLL
DP
V
R
L
HL
Q
NG
G
S
W
RH
LALGVAGWMRY
TQ
GVD
EQ
GNAIDV
V
DP
M
--
L
A
E
F
Q
K
I
N
AQ
YQ
-----
GA
D
RV
K
ALL
G
L
SGI
F
A
DDLPQN
A
D
FV
G
AV
TA
A
Y
QQ
L
C
E
R
GARE
C
V
A
AL
fig|679204.3.peg.2718
Escherichia coli MS 145-7 (13-486/486)
R
PSWDHSR
L
E
SRIVH
L
G
C
GAFHRAHQAL
Y
T
H
H
LLE
S
TD
S
DWGICEV
N
L
MP
G
N
D
RV
L
IEN
L
KK
Q
QL
LYTV
A
-----
EKGA
ES
TE
L
K
IIGS
M
K
E
--
A
L
H
P
E
I
D
GCEG
IL
NAMAR
PQ
T
AIVSLT
V
TEKGYC
A
D
A
A
S
G
Q
LD
L
N
NP
L
I
K
HDL
E
NP
TA
P
K
SA
I
G
Y
I
VEAL
RL
RRE
K
GLK
A
FTV
M
SCDN
V
RE
NGHV
A
K
V
AVLG
L
AQ
A
R
D
-
P
Q
-
LA
A
WI
E
E
N
V
T
FP
C
TMVDRIVPAAT
P
E
T
L
Q
EI
A
D
Q
LGV
Y
DPCAI
A
CEPF
R
QWVIE
-----------
DNFV
N
GRP
D
W
DKV
G
A
Q
F
V
A
DV
V
P
F
E
M
MKLRMLNGSHSFLAYLGYL
G
G
YE
TI
A
D
T
M
T
N
PDY
R
K
AA
FA
LM
M
Q
EQAPTL
S
M
P
E
G
T
DL
NA
YA
TL
LI
E
RF
S
NP
S
L
R
H
R
TWQIAMDGSQK
-----
LPQRLL
DP
V
R
L
HL
Q
NG
G
S
W
RH
LALGVAGWMRY
TQ
GVD
EQ
GNAIDV
V
DP
M
--
L
A
E
F
Q
K
I
N
AQ
YQ
-----
GA
D
RV
K
ALL
G
L
SGI
F
A
DDLPQN
A
D
FV
G
AV
TA
A
Y
QQ
L
C
E
R
GARE
C
V
A
AL
fig|749545.3.peg.4248
Escherichia coli MS 182-1 (13-486/486)
R
PSWDHSR
L
E
SRIVH
L
G
C
GAFHRAHQAL
Y
T
H
H
LLE
S
TD
S
DWGICEV
N
L
MP
G
N
D
RV
L
IEN
L
KK
Q
QL
LYTV
A
-----
EKGA
ES
TE
L
K
IIGS
M
K
E
--
A
L
H
P
E
I
D
GCEG
IL
NAMAR
PQ
T
AIVSLT
V
TEKGYC
A
D
A
A
S
G
Q
LD
L
N
NP
L
I
K
HDL
E
NP
TA
P
K
SA
I
G
Y
I
VEAL
RL
RRE
K
GLK
A
FTV
M
SCDN
V
RE
NGHV
A
K
V
AVLG
L
AQ
A
R
D
-
P
Q
-
LA
A
WI
E
E
N
V
T
FP
C
TMVDRIVPAAT
P
E
T
L
Q
EI
A
D
Q
LGV
Y
DPCAI
A
CEPF
R
QWVIE
-----------
DNFV
N
GRP
D
W
DKV
G
A
Q
F
V
A
DV
V
P
F
E
M
MKLRMLNGSHSFLAYLGYL
G
G
YE
TI
A
D
T
M
T
N
PDY
R
K
AA
FA
LM
M
Q
EQAPTL
S
M
P
E
G
T
DL
NA
YA
TL
LI
E
RF
S
NP
S
L
R
H
R
TWQIAMDGSQK
-----
LPQRLL
DP
V
R
L
HL
Q
NG
G
S
W
RH
LALGVAGWMRY
TQ
GVD
EQ
GNAIDV
V
DP
M
--
L
A
E
F
Q
K
I
N
AQ
YQ
-----
GA
D
RV
K
ALL
G
L
SGI
F
A
DDLPQN
A
D
FV
G
AV
TA
A
Y
QQ
L
C
E
R
GARE
C
V
A
AL
fig|749532.3.peg.292
Escherichia coli MS 78-1 (13-486/486)
R
PSWDHSR
L
E
SRIVH
L
G
C
GAFHRAHQAL
Y
T
H
H
LLE
S
TD
S
DWGICEV
N
L
MP
G
N
D
RV
L
IEN
L
KK
Q
QL
LYTV
A
-----
EKGA
ES
TE
L
K
IIGS
M
K
E
--
A
L
H
P
E
I
D
GCEG
IL
NAMAR
PQ
T
AIVSLT
V
TEKGYC
A
D
A
A
S
G
Q
LD
L
N
NP
L
I
K
HDL
E
NP
TA
P
K
SA
I
G
Y
I
VEAL
RL
RRE
K
GLK
A
FTV
M
SCDN
V
RE
NGHV
A
K
V
AVLG
L
AQ
A
R
D
-
P
Q
-
LA
A
WI
E
E
N
V
T
FP
C
TMVDRIVPAAT
P
E
T
L
Q
EI
A
D
Q
LGV
Y
DPCAI
A
CEPF
R
QWVIE
-----------
DNFV
N
GRP
D
W
DKV
G
A
Q
F
V
A
DV
V
P
F
E
M
MKLRMLNGSHSFLAYLGYL
G
G
YE
TI
A
D
T
M
T
N
PDY
R
K
AA
FA
LM
M
Q
EQAPTL
S
M
P
E
G
T
DL
NA
YA
TL
LI
E
RF
S
NP
S
L
R
H
R
TWQIAMDGSQK
-----
LPQRLL
DP
V
R
L
HL
Q
NG
G
S
W
RH
LALGVAGWMRY
TQ
GVD
EQ
GNAIDV
V
DP
M
--
L
A
E
F
Q
K
I
N
AQ
YQ
-----
GA
D
RV
K
ALL
G
L
SGI
F
A
DDLPQN
A
D
FV
G
AV
TA
A
Y
QQ
L
C
E
R
GARE
C
V
A
AL
fig|83334.1.peg.5262
Escherichia coli O157:H7 (13-486/486)
R
PSWDHSR
L
E
SRIVH
L
G
C
GAFHRAHQAL
Y
T
H
H
LLE
S
TD
S
DWGICEV
N
L
MP
G
N
D
RV
L
IEN
L
KK
Q
QL
LYTV
A
-----
EKGA
ES
TE
L
K
IIGS
M
K
E
--
A
L
H
P
E
I
D
GCEG
IL
NAMAR
PQ
T
AIVSLT
V
TEKGYC
A
D
A
A
S
G
Q
LD
L
N
NP
L
I
K
HDL
E
NP
TA
P
K
SA
I
G
Y
I
VEAL
RL
RRE
K
GLK
A
FTV
M
SCDN
V
RE
NGHV
A
K
V
AVLG
L
AQ
A
R
D
-
P
Q
-
LA
A
WI
E
E
N
V
T
FP
C
TMVDRIVPAAT
P
E
T
L
Q
EI
A
D
Q
LGV
Y
DPCAI
A
CEPF
R
QWVIE
-----------
DNFV
N
GRP
D
W
DKV
G
A
Q
F
V
A
DV
V
P
F
E
M
MKLRMLNGSHSFLAYLGYL
G
G
YE
TI
A
D
T
M
T
N
PDY
R
K
AA
FA
LM
M
Q
EQAPTL
S
M
P
E
G
T
DL
NA
YA
TL
LI
E
RF
S
NP
S
L
R
H
R
TWQIAMDGSQK
-----
LPQRLL
DP
V
R
L
HL
Q
NG
G
S
W
RH
LALGVAGWMRY
TQ
GVD
EQ
GNAIDV
V
DP
M
--
L
A
E
F
Q
K
I
N
AQ
YQ
-----
GA
D
RV
K
ALL
G
L
SGI
F
A
DDLPQN
A
D
FV
G
AV
TA
A
Y
QQ
L
C
E
R
GARE
C
V
A
AL
fig|155864.1.peg.5247
Escherichia coli O157:H7 EDL933 (13-486/486)
R
PSWDHSR
L
E
SRIVH
L
G
C
GAFHRAHQAL
Y
T
H
H
LLE
S
TD
S
DWGICEV
N
L
MP
G
N
D
RV
L
IEN
L
KK
Q
QL
LYTV
A
-----
EKGA
ES
TE
L
K
IIGS
M
K
E
--
A
L
H
P
E
I
D
GCEG
IL
NAMAR
PQ
T
AIVSLT
V
TEKGYC
A
D
A
A
S
G
Q
LD
L
N
NP
L
I
K
HDL
E
NP
TA
P
K
SA
I
G
Y
I
VEAL
RL
RRE
K
GLK
A
FTV
M
SCDN
V
RE
NGHV
A
K
V
AVLG
L
AQ
A
R
D
-
P
Q
-
LA
A
WI
E
E
N
V
T
FP
C
TMVDRIVPAAT
P
E
T
L
Q
EI
A
D
Q
LGV
Y
DPCAI
A
CEPF
R
QWVIE
-----------
DNFV
N
GRP
D
W
DKV
G
A
Q
F
V
A
DV
V
P
F
E
M
MKLRMLNGSHSFLAYLGYL
G
G
YE
TI
A
D
T
M
T
N
PDY
R
K
AA
FA
LM
M
Q
EQAPTL
S
M
P
E
G
T
DL
NA
YA
TL
LI
E
RF
S
NP
S
L
R
H
R
TWQIAMDGSQK
-----
LPQRLL
DP
V
R
L
HL
Q
NG
G
S
W
RH
LALGVAGWMRY
TQ
GVD
EQ
GNAIDV
V
DP
M
--
L
A
E
F
Q
K
I
N
AQ
YQ
-----
GA
D
RV
K
ALL
G
L
SGI
F
A
DDLPQN
A
D
FV
G
AV
TA
A
Y
QQ
L
C
E
R
GARE
C
V
A
AL
fig|155864.8.peg.5233
Escherichia coli O157:H7 EDL933 (13-486/486)
R
PSWDHSR
L
E
SRIVH
L
G
C
GAFHRAHQAL
Y
T
H
H
LLE
S
TD
S
DWGICEV
N
L
MP
G
N
D
RV
L
IEN
L
KK
Q
QL
LYTV
A
-----
EKGA
ES
TE
L
K
IIGS
M
K
E
--
A
L
H
P
E
I
D
GCEG
IL
NAMAR
PQ
T
AIVSLT
V
TEKGYC
A
D
A
A
S
G
Q
LD
L
N
NP
L
I
K
HDL
E
NP
TA
P
K
SA
I
G
Y
I
VEAL
RL
RRE
K
GLK
A
FTV
M
SCDN
V
RE
NGHV
A
K
V
AVLG
L
AQ
A
R
D
-
P
Q
-
LA
A
WI
E
E
N
V
T
FP
C
TMVDRIVPAAT
P
E
T
L
Q
EI
A
D
Q
LGV
Y
DPCAI
A
CEPF
R
QWVIE
-----------
DNFV
N
GRP
D
W
DKV
G
A
Q
F
V
A
DV
V
P
F
E
M
MKLRMLNGSHSFLAYLGYL
G
G
YE
TI
A
D
T
M
T
N
PDY
R
K
AA
FA
LM
M
Q
EQAPTL
S
M
P
E
G
T
DL
NA
YA
TL
LI
E
RF
S
NP
S
L
R
H
R
TWQIAMDGSQK
-----
LPQRLL
DP
V
R
L
HL
Q
NG
G
S
W
RH
LALGVAGWMRY
TQ
GVD
EQ
GNAIDV
V
DP
M
--
L
A
E
F
Q
K
I
N
AQ
YQ
-----
GA
D
RV
K
ALL
G
L
SGI
F
A
DDLPQN
A
D
FV
G
AV
TA
A
Y
QQ
L
C
E
R
GARE
C
V
A
AL
fig|444454.5.peg.4370
Escherichia coli O157:H7 str. EC4024 (13-486/486)
R
PSWDHSR
L
E
SRIVH
L
G
C
GAFHRAHQAL
Y
T
H
H
LLE
S
TD
S
DWGICEV
N
L
MP
G
N
D
RV
L
IEN
L
KK
Q
QL
LYTV
A
-----
EKGA
ES
TE
L
K
IIGS
M
K
E
--
A
L
H
P
E
I
D
GCEG
IL
NAMAR
PQ
T
AIVSLT
V
TEKGYC
A
D
A
A
S
G
Q
LD
L
N
NP
L
I
K
HDL
E
NP
TA
P
K
SA
I
G
Y
I
VEAL
RL
RRE
K
GLK
A
FTV
M
SCDN
V
RE
NGHV
A
K
V
AVLG
L
AQ
A
R
D
-
P
Q
-
LA
A
WI
E
E
N
V
T
FP
C
TMVDRIVPAAT
P
E
T
L
Q
EI
A
D
Q
LGV
Y
DPCAI
A
CEPF
R
QWVIE
-----------
DNFV
N
GRP
D
W
DKV
G
A
Q
F
V
A
DV
V
P
F
E
M
MKLRMLNGSHSFLAYLGYL
G
G
YE
TI
A
D
T
M
T
N
PDY
R
K
AA
FA
LM
M
Q
EQAPTL
S
M
P
E
G
T
DL
NA
YA
TL
LI
E
RF
S
NP
S
L
R
H
R
TWQIAMDGSQK
-----
LPQRLL
DP
V
R
L
HL
Q
NG
G
S
W
RH
LALGVAGWMRY
TQ
GVD
EQ
GNAIDV
V
DP
M
--
L
A
E
F
Q
K
I
N
AQ
YQ
-----
GA
D
RV
K
ALL
G
L
SGI
F
A
DDLPQN
A
D
FV
G
AV
TA
A
Y
QQ
L
C
E
R
GARE
C
V
A
AL
fig|444449.5.peg.3823
Escherichia coli O157:H7 str. EC4042 (13-486/486)
R
PSWDHSR
L
E
SRIVH
L
G
C
GAFHRAHQAL
Y
T
H
H
LLE
S
TD
S
DWGICEV
N
L
MP
G
N
D
RV
L
IEN
L
KK
Q
QL
LYTV
A
-----
EKGA
ES
TE
L
K
IIGS
M
K
E
--
A
L
H
P
E
I
D
GCEG
IL
NAMAR
PQ
T
AIVSLT
V
TEKGYC
A
D
A
A
S
G
Q
LD
L
N
NP
L
I
K
HDL
E
NP
TA
P
K
SA
I
G
Y
I
VEAL
RL
RRE
K
GLK
A
FTV
M
SCDN
V
RE
NGHV
A
K
V
AVLG
L
AQ
A
R
D
-
P
Q
-
LA
A
WI
E
E
N
V
T
FP
C
TMVDRIVPAAT
P
E
T
L
Q
EI
A
D
Q
LGV
Y
DPCAI
A
CEPF
R
QWVIE
-----------
DNFV
N
GRP
D
W
DKV
G
A
Q
F
V
A
DV
V
P
F
E
M
MKLRMLNGSHSFLAYLGYL
G
G
YE
TI
A
D
T
M
T
N
PDY
R
K
AA
FA
LM
M
Q
EQAPTL
S
M
P
E
G
T
DL
NA
YA
TL
LI
E
RF
S
NP
S
L
R
H
R
TWQIAMDGSQK
-----
LPQRLL
DP
V
R
L
HL
Q
NG
G
S
W
RH
LALGVAGWMRY
TQ
GVD
EQ
GNAIDV
V
DP
M
--
L
A
E
F
Q
K
I
N
AQ
YQ
-----
GA
D
RV
K
ALL
G
L
SGI
F
A
DDLPQN
A
D
FV
G
AV
TA
A
Y
QQ
L
C
E
R
GARE
C
V
A
AL
fig|444448.5.peg.2580
Escherichia coli O157:H7 str. EC4045 (13-486/486)
R
PSWDHSR
L
E
SRIVH
L
G
C
GAFHRAHQAL
Y
T
H
H
LLE
S
TD
S
DWGICEV
N
L
MP
G
N
D
RV
L
IEN
L
KK
Q
QL
LYTV
A
-----
EKGA
ES
TE
L
K
IIGS
M
K
E
--
A
L
H
P
E
I
D
GCEG
IL
NAMAR
PQ
T
AIVSLT
V
TEKGYC
A
D
A
A
S
G
Q
LD
L
N
NP
L
I
K
HDL
E
NP
TA
P
K
SA
I
G
Y
I
VEAL
RL
RRE
K
GLK
A
FTV
M
SCDN
V
RE
NGHV
A
K
V
AVLG
L
AQ
A
R
D
-
P
Q
-
LA
A
WI
E
E
N
V
T
FP
C
TMVDRIVPAAT
P
E
T
L
Q
EI
A
D
Q
LGV
Y
DPCAI
A
CEPF
R
QWVIE
-----------
DNFV
N
GRP
D
W
DKV
G
A
Q
F
V
A
DV
V
P
F
E
M
MKLRMLNGSHSFLAYLGYL
G
G
YE
TI
A
D
T
M
T
N
PDY
R
K
AA
FA
LM
M
Q
EQAPTL
S
M
P
E
G
T
DL
NA
YA
TL
LI
E
RF
S
NP
S
L
R
H
R
TWQIAMDGSQK
-----
LPQRLL
DP
V
R
L
HL
Q
NG
G
S
W
RH
LALGVAGWMRY
TQ
GVD
EQ
GNAIDV
V
DP
M
--
L
A
E
F
Q
K
I
N
AQ
YQ
-----
GA
D
RV
K
ALL
G
L
SGI
F
A
DDLPQN
A
D
FV
G
AV
TA
A
Y
QQ
L
C
E
R
GARE
C
V
A
AL
fig|444453.5.peg.3017
Escherichia coli O157:H7 str. EC4076 (13-486/486)
R
PSWDHSR
L
E
SRIVH
L
G
C
GAFHRAHQAL
Y
T
H
H
LLE
S
TD
S
DWGICEV
N
L
MP
G
N
D
RV
L
IEN
L
KK
Q
QL
LYTV
A
-----
EKGA
ES
TE
L
K
IIGS
M
K
E
--
A
L
H
P
E
I
D
GCEG
IL
NAMAR
PQ
T
AIVSLT
V
TEKGYC
A
D
A
A
S
G
Q
LD
L
N
NP
L
I
K
HDL
E
NP
TA
P
K
SA
I
G
Y
I
VEAL
RL
RRE
K
GLK
A
FTV
M
SCDN
V
RE
NGHV
A
K
V
AVLG
L
AQ
A
R
D
-
P
Q
-
LA
A
WI
E
E
N
V
T
FP
C
TMVDRIVPAAT
P
E
T
L
Q
EI
A
D
Q
LGV
Y
DPCAI
A
CEPF
R
QWVIE
-----------
DNFV
N
GRP
D
W
DKV
G
A
Q
F
V
A
DV
V
P
F
E
M
MKLRMLNGSHSFLAYLGYL
G
G
YE
TI
A
D
T
M
T
N
PDY
R
K
AA
FA
LM
M
Q
EQAPTL
S
M
P
E
G
T
DL
NA
YA
TL
LI
E
RF
S
NP
S
L
R
H
R
TWQIAMDGSQK
-----
LPQRLL
DP
V
R
L
HL
Q
NG
G
S
W
RH
LALGVAGWMRY
TQ
GVD
EQ
GNAIDV
V
DP
M
--
L
A
E
F
Q
K
I
N
AQ
YQ
-----
GA
D
RV
K
ALL
G
L
SGI
F
A
DDLPQN
A
D
FV
G
AV
TA
A
Y
QQ
L
C
E
R
GARE
C
V
A
AL
fig|444452.5.peg.2526
Escherichia coli O157:H7 str. EC4113 (13-486/486)
R
PSWDHSR
L
E
SRIVH
L
G
C
GAFHRAHQAL
Y
T
H
H
LLE
S
TD
S
DWGICEV
N
L
MP
G
N
D
RV
L
IEN
L
KK
Q
QL
LYTV
A
-----
EKGA
ES
TE
L
K
IIGS
M
K
E
--
A
L
H
P
E
I
D
GCEG
IL
NAMAR
PQ
T
AIVSLT
V
TEKGYC
A
D
A
A
S
G
Q
LD
L
N
NP
L
I
K
HDL
E
NP
TA
P
K
SA
I
G
Y
I
VEAL
RL
RRE
K
GLK
A
FTV
M
SCDN
V
RE
NGHV
A
K
V
AVLG
L
AQ
A
R
D
-
P
Q
-
LA
A
WI
E
E
N
V
T
FP
C
TMVDRIVPAAT
P
E
T
L
Q
EI
A
D
Q
LGV
Y
DPCAI
A
CEPF
R
QWVIE
-----------
DNFV
N
GRP
D
W
DKV
G
A
Q
F
V
A
DV
V
P
F
E
M
MKLRMLNGSHSFLAYLGYL
G
G
YE
TI
A
D
T
M
T
N
PDY
R
K
AA
FA
LM
M
Q
EQAPTL
S
M
P
E
G
T
DL
NA
YA
TL
LI
E
RF
S
NP
S
L
R
H
R
TWQIAMDGSQK
-----
LPQRLL
DP
V
R
L
HL
Q
NG
G
S
W
RH
LALGVAGWMRY
TQ
GVD
EQ
GNAIDV
V
DP
M
--
L
A
E
F
Q
K
I
N
AQ
YQ
-----
GA
D
RV
K
ALL
G
L
SGI
F
A
DDLPQN
A
D
FV
G
AV
TA
A
Y
QQ
L
C
E
R
GARE
C
V
A
AL
fig|444450.8.peg.5660
Escherichia coli O157:H7 str. EC4115 (13-486/486)
R
PSWDHSR
L
E
SRIVH
L
G
C
GAFHRAHQAL
Y
T
H
H
LLE
S
TD
S
DWGICEV
N
L
MP
G
N
D
RV
L
IEN
L
KK
Q
QL
LYTV
A
-----
EKGA
ES
TE
L
K
IIGS
M
K
E
--
A
L
H
P
E
I
D
GCEG
IL
NAMAR
PQ
T
AIVSLT
V
TEKGYC
A
D
A
A
S
G
Q
LD
L
N
NP
L
I
K
HDL
E
NP
TA
P
K
SA
I
G
Y
I
VEAL
RL
RRE
K
GLK
A
FTV
M
SCDN
V
RE
NGHV
A
K
V
AVLG
L
AQ
A
R
D
-
P
Q
-
LA
A
WI
E
E
N
V
T
FP
C
TMVDRIVPAAT
P
E
T
L
Q
EI
A
D
Q
LGV
Y
DPCAI
A
CEPF
R
QWVIE
-----------
DNFV
N
GRP
D
W
DKV
G
A
Q
F
V
A
DV
V
P
F
E
M
MKLRMLNGSHSFLAYLGYL
G
G
YE
TI
A
D
T
M
T
N
PDY
R
K
AA
FA
LM
M
Q
EQAPTL
S
M
P
E
G
T
DL
NA
YA
TL
LI
E
RF
S
NP
S
L
R
H
R
TWQIAMDGSQK
-----
LPQRLL
DP
V
R
L
HL
Q
NG
G
S
W
RH
LALGVAGWMRY
TQ
GVD
EQ
GNAIDV
V
DP
M
--
L
A
E
F
Q
K
I
N
AQ
YQ
-----
GA
D
RV
K
ALL
G
L
SGI
F
A
DDLPQN
A
D
FV
G
AV
TA
A
Y
QQ
L
C
E
R
GARE
C
V
A
AL
fig|444451.5.peg.1630
Escherichia coli O157:H7 str. EC4196 (13-486/486)
R
PSWDHSR
L
E
SRIVH
L
G
C
GAFHRAHQAL
Y
T
H
H
LLE
S
TD
S
DWGICEV
N
L
MP
G
N
D
RV
L
IEN
L
KK
Q
QL
LYTV
A
-----
EKGA
ES
TE
L
K
IIGS
M
K
E
--
A
L
H
P
E
I
D
GCEG
IL
NAMAR
PQ
T
AIVSLT
V
TEKGYC
A
D
A
A
S
G
Q
LD
L
N
NP
L
I
K
HDL
E
NP
TA
P
K
SA
I
G
Y
I
VEAL
RL
RRE
K
GLK
A
FTV
M
SCDN
V
RE
NGHV
A
K
V
AVLG
L
AQ
A
R
D
-
P
Q
-
LA
A
WI
E
E
N
V
T
FP
C
TMVDRIVPAAT
P
E
T
L
Q
EI
A
D
Q
LGV
Y
DPCAI
A
CEPF
R
QWVIE
-----------
DNFV
N
GRP
D
W
DKV
G
A
Q
F
V
A
DV
V
P
F
E
M
MKLRMLNGSHSFLAYLGYL
G
G
YE
TI
A
D
T
M
T
N
PDY
R
K
AA
FA
LM
M
Q
EQAPTL
S
M
P
E
G
T
DL
NA
YA
TL
LI
E
RF
S
NP
S
L
R
H
R
TWQIAMDGSQK
-----
LPQRLL
DP
V
R
L
HL
Q
NG
G
S
W
RH
LALGVAGWMRY
TQ
GVD
EQ
GNAIDV
V
DP
M
--
L
A
E
F
Q
K
I
N
AQ
YQ
-----
GA
D
RV
K
ALL
G
L
SGI
F
A
DDLPQN
A
D
FV
G
AV
TA
A
Y
QQ
L
C
E
R
GARE
C
V
A
AL
fig|444447.5.peg.2746
Escherichia coli O157:H7 str. EC4206 (13-486/486)
R
PSWDHSR
L
E
SRIVH
L
G
C
GAFHRAHQAL
Y
T
H
H
LLE
S
TD
S
DWGICEV
N
L
MP
G
N
D
RV
L
IEN
L
KK
Q
QL
LYTV
A
-----
EKGA
ES
TE
L
K
IIGS
M
K
E
--
A
L
H
P
E
I
D
GCEG
IL
NAMAR
PQ
T
AIVSLT
V
TEKGYC
A
D
A
A
S
G
Q
LD
L
N
NP
L
I
K
HDL
E
NP
TA
P
K
SA
I
G
Y
I
VEAL
RL
RRE
K
GLK
A
FTV
M
SCDN
V
RE
NGHV
A
K
V
AVLG
L
AQ
A
R
D
-
P
Q
-
LA
A
WI
E
E
N
V
T
FP
C
TMVDRIVPAAT
P
E
T
L
Q
EI
A
D
Q
LGV
Y
DPCAI
A
CEPF
R
QWVIE
-----------
DNFV
N
GRP
D
W
DKV
G
A
Q
F
V
A
DV
V
P
F
E
M
MKLRMLNGSHSFLAYLGYL
G
G
YE
TI
A
D
T
M
T
N
PDY
R
K
AA
FA
LM
M
Q
EQAPTL
S
M
P
E
G
T
DL
NA
YA
TL
LI
E
RF
S
NP
S
L
R
H
R
TWQIAMDGSQK
-----
LPQRLL
DP
V
R
L
HL
Q
NG
G
S
W
RH
LALGVAGWMRY
TQ
GVD
EQ
GNAIDV
V
DP
M
--
L
A
E
F
Q
K
I
N
AQ
YQ
-----
GA
D
RV
K
ALL
G
L
SGI
F
A
DDLPQN
A
D
FV
G
AV
TA
A
Y
QQ
L
C
E
R
GARE
C
V
A
AL
fig|478004.5.peg.1679
Escherichia coli O157:H7 str. EC4401 (13-486/486)
R
PSWDHSR
L
E
SRIVH
L
G
C
GAFHRAHQAL
Y
T
H
H
LLE
S
TD
S
DWGICEV
N
L
MP
G
N
D
RV
L
IEN
L
KK
Q
QL
LYTV
A
-----
EKGA
ES
TE
L
K
IIGS
M
K
E
--
A
L
H
P
E
I
D
GCEG
IL
NAMAR
PQ
T
AIVSLT
V
TEKGYC
A
D
A
A
S
G
Q
LD
L
N
NP
L
I
K
HDL
E
NP
TA
P
K
SA
I
G
Y
I
VEAL
RL
RRE
K
GLK
A
FTV
M
SCDN
V
RE
NGHV
A
K
V
AVLG
L
AQ
A
R
D
-
P
Q
-
LA
A
WI
E
E
N
V
T
FP
C
TMVDRIVPAAT
P
E
T
L
Q
EI
A
D
Q
LGV
Y
DPCAI
A
CEPF
R
QWVIE
-----------
DNFV
N
GRP
D
W
DKV
G
A
Q
F
V
A
DV
V
P
F
E
M
MKLRMLNGSHSFLAYLGYL
G
G
YE
TI
A
D
T
M
T
N
PDY
R
K
AA
FA
LM
M
Q
EQAPTL
S
M
P
E
G
T
DL
NA
YA
TL
LI
E
RF
S
NP
S
L
R
H
R
TWQIAMDGSQK
-----
LPQRLL
DP
V
R
L
HL
Q
NG
G
S
W
RH
LALGVAGWMRY
TQ
GVD
EQ
GNAIDV
V
DP
M
--
L
A
E
F
Q
K
I
N
AQ
YQ
-----
GA
D
RV
K
ALL
G
L
SGI
F
A
DDLPQN
A
D
FV
G
AV
TA
A
Y
QQ
L
C
E
R
GARE
C
V
A
AL
fig|478005.5.peg.794
Escherichia coli O157:H7 str. EC4486 (13-486/486)
R
PSWDHSR
L
E
SRIVH
L
G
C
GAFHRAHQAL
Y
T
H
H
LLE
S
TD
S
DWGICEV
N
L
MP
G
N
D
RV
L
IEN
L
KK
Q
QL
LYTV
A
-----
EKGA
ES
TE
L
K
IIGS
M
K
E
--
A
L
H
P
E
I
D
GCEG
IL
NAMAR
PQ
T
AIVSLT
V
TEKGYC
A
D
A
A
S
G
Q
LD
L
N
NP
L
I
K
HDL
E
NP
TA
P
K
SA
I
G
Y
I
VEAL
RL
RRE
K
GLK
A
FTV
M
SCDN
V
RE
NGHV
A
K
V
AVLG
L
AQ
A
R
D
-
P
Q
-
LA
A
WI
E
E
N
V
T
FP
C
TMVDRIVPAAT
P
E
T
L
Q
EI
A
D
Q
LGV
Y
DPCAI
A
CEPF
R
QWVIE
-----------
DNFV
N
GRP
D
W
DKV
G
A
Q
F
V
A
DV
V
P
F
E
M
MKLRMLNGSHSFLAYLGYL
G
G
YE
TI
A
D
T
M
T
N
PDY
R
K
AA
FA
LM
M
Q
EQAPTL
S
M
P
E
G
T
DL
NA
YA
TL
LI
E
RF
S
NP
S
L
R
H
R
TWQIAMDGSQK
-----
LPQRLL
DP
V
R
L
HL
Q
NG
G
S
W
RH
LALGVAGWMRY
TQ
GVD
EQ
GNAIDV
V
DP
M
--
L
A
E
F
Q
K
I
N
AQ
YQ
-----
GA
D
RV
K
ALL
G
L
SGI
F
A
DDLPQN
A
D
FV
G
AV
TA
A
Y
QQ
L
C
E
R
GARE
C
V
A
AL
fig|478006.5.peg.1111
Escherichia coli O157:H7 str. EC4501 (13-486/486)
R
PSWDHSR
L
E
SRIVH
L
G
C
GAFHRAHQAL
Y
T
H
H
LLE
S
TD
S
DWGICEV
N
L
MP
G
N
D
RV
L
IEN
L
KK
Q
QL
LYTV
A
-----
EKGA
ES
TE
L
K
IIGS
M
K
E
--
A
L
H
P
E
I
D
GCEG
IL
NAMAR
PQ
T
AIVSLT
V
TEKGYC
A
D
A
A
S
G
Q
LD
L
N
NP
L
I
K
HDL
E
NP
TA
P
K
SA
I
G
Y
I
VEAL
RL
RRE
K
GLK
A
FTV
M
SCDN
V
RE
NGHV
A
K
V
AVLG
L
AQ
A
R
D
-
P
Q
-
LA
A
WI
E
E
N
V
T
FP
C
TMVDRIVPAAT
P
E
T
L
Q
EI
A
D
Q
LGV
Y
DPCAI
A
CEPF
R
QWVIE
-----------
DNFV
N
GRP
D
W
DKV
G
A
Q
F
V
A
DV
V
P
F
E
M
MKLRMLNGSHSFLAYLGYL
G
G
YE
TI
A
D
T
M
T
N
PDY
R
K
AA
FA
LM
M
Q
EQAPTL
S
M
P
E
G
T
DL
NA
YA
TL
LI
E
RF
S
NP
S
L
R
H
R
TWQIAMDGSQK
-----
LPQRLL
DP
V
R
L
HL
Q
NG
G
S
W
RH
LALGVAGWMRY
TQ
GVD
EQ
GNAIDV
V
DP
M
--
L
A
E
F
Q
K
I
N
AQ
YQ
-----
GA
D
RV
K
ALL
G
L
SGI
F
A
DDLPQN
A
D
FV
G
AV
TA
A
Y
QQ
L
C
E
R
GARE
C
V
A
AL
fig|478007.5.peg.729
Escherichia coli O157:H7 str. EC508 (13-486/486)
R
PSWDHSR
L
E
SRIVH
L
G
C
GAFHRAHQAL
Y
T
H
H
LLE
S
TD
S
DWGICEV
N
L
MP
G
N
D
RV
L
IEN
L
KK
Q
QL
LYTV
A
-----
EKGA
ES
TE
L
K
IIGS
M
K
E
--
A
L
H
P
E
I
D
GCEG
IL
NAMAR
PQ
T
AIVSLT
V
TEKGYC
A
D
A
A
S
G
Q
LD
L
N
NP
L
I
K
HDL
E
NP
TA
P
K
SA
I
G
Y
I
VEAL
RL
RRE
K
GLK
A
FTV
M
SCDN
V
RE
NGHV
A
K
V
AVLG
L
AQ
A
R
D
-
P
Q
-
LA
A
WI
E
E
N
V
T
FP
C
TMVDRIVPAAT
P
E
T
L
Q
EI
A
D
Q
LGV
Y
DPCAI
A
CEPF
R
QWVIE
-----------
DNFV
N
GRP
D
W
DKV
G
A
Q
F
V
A
DV
V
P
F
E
M
MKLRMLNGSHSFLAYLGYL
G
G
YE
TI
A
D
T
M
T
N
PDY
R
K
AA
FA
LM
M
Q
EQAPTL
S
M
P
E
G
T
DL
NA
YA
TL
LI
E
RF
S
NP
S
L
R
H
R
TWQIAMDGSQK
-----
LPQRLL
DP
V
R
L
HL
Q
NG
G
S
W
RH
LALGVAGWMRY
TQ
GVD
EQ
GNAIDV
V
DP
M
--
L
A
E
F
Q
K
I
N
AQ
YQ
-----
GA
D
RV
K
ALL
G
L
SGI
F
A
DDLPQN
A
D
FV
G
AV
TA
A
Y
QQ
L
C
E
R
GARE
C
V
A
AL
fig|478008.5.peg.340
Escherichia coli O157:H7 str. EC869 (13-486/486)
R
PSWDHSR
L
E
SRIVH
L
G
C
GAFHRAHQAL
Y
T
H
H
LLE
S
TD
S
DWGICEV
N
L
MP
G
N
D
RV
L
IEN
L
KK
Q
QL
LYTV
A
-----
EKGA
ES
TE
L
K
IIGS
M
K
E
--
A
L
H
P
E
I
D
GCEG
IL
NAMAR
PQ
T
AIVSLT
V
TEKGYC
A
D
A
A
S
G
Q
LD
L
N
NP
L
I
K
HDL
E
NP
TA
P
K
SA
I
G
Y
I
VEAL
RL
RRE
K
GLK
A
FTV
M
SCDN
V
RE
NGHV
A
K
V
AVLG
L
AQ
A
R
D
-
P
Q
-
LA
A
WI
E
E
N
V
T
FP
C
TMVDRIVPAAT
P
E
T
L
Q
EI
A
D
Q
LGV
Y
DPCAI
A
CEPF
R
QWVIE
-----------
DNFV
N
GRP
D
W
DKV
G
A
Q
F
V
A
DV
V
P
F
E
M
MKLRMLNGSHSFLAYLGYL
G
G
YE
TI
A
D
T
M
T
N
PDY
R
K
AA
FA
LM
M
Q
EQAPTL
S
M
P
E
G
T
DL
NA
YA
TL
LI
E
RF
S
NP
S
L
R
H
R
TWQIAMDGSQK
-----
LPQRLL
DP
V
R
L
HL
Q
NG
G
S
W
RH
LALGVAGWMRY
TQ
GVD
EQ
GNAIDV
V
DP
M
--
L
A
E
F
Q
K
I
N
AQ
YQ
-----
GA
D
RV
K
ALL
G
L
SGI
F
A
DDLPQN
A
D
FV
G
AV
TA
A
Y
QQ
L
C
E
R
GARE
C
V
A
AL
fig|637388.3.peg.3750
Escherichia coli O157:H7 str. FRIK2000 (13-486/486)
R
PSWDHSR
L
E
SRIVH
L
G
C
GAFHRAHQAL
Y
T
H
H
LLE
S
TD
S
DWGICEV
N
L
MP
G
N
D
RV
L
IEN
L
KK
Q
QL
LYTV
A
-----
EKGA
ES
TE
L
K
IIGS
M
K
E
--
A
L
H
P
E
I
D
GCEG
IL
NAMAR
PQ
T
AIVSLT
V
TEKGYC
A
D
A
A
S
G
Q
LD
L
N
NP
L
I
K
HDL
E
NP
TA
P
K
SA
I
G
Y
I
VEAL
RL
RRE
K
GLK
A
FTV
M
SCDN
V
RE
NGHV
A
K
V
AVLG
L
AQ
A
R
D
-
P
Q
-
LA
A
WI
E
E
N
V
T
FP
C
TMVDRIVPAAT
P
E
T
L
Q
EI
A
D
Q
LGV
Y
DPCAI
A
CEPF
R
QWVIE
-----------
DNFV
N
GRP
D
W
DKV
G
A
Q
F
V
A
DV
V
P
F
E
M
MKLRMLNGSHSFLAYLGYL
G
G
YE
TI
A
D
T
M
T
N
PDY
R
K
AA
FA
LM
M
Q
EQAPTL
S
M
P
E
G
T
DL
NA
YA
TL
LI
E
RF
S
NP
S
L
R
H
R
TWQIAMDGSQK
-----
LPQRLL
DP
V
R
L
HL
Q
NG
G
S
W
RH
LALGVAGWMRY
TQ
GVD
EQ
GNAIDV
V
DP
M
--
L
A
E
F
Q
K
I
N
AQ
YQ
-----
GA
D
RV
K
ALL
G
L
SGI
F
A
DDLPQN
A
D
FV
G
AV
TA
A
Y
QQ
L
C
E
R
GARE
C
V
A
AL
fig|570506.3.peg.2808
Escherichia coli O157:H7 str. FRIK966 (13-486/486)
R
PSWDHSR
L
E
SRIVH
L
G
C
GAFHRAHQAL
Y
T
H
H
LLE
S
TD
S
DWGICEV
N
L
MP
G
N
D
RV
L
IEN
L
KK
Q
QL
LYTV
A
-----
EKGA
ES
TE
L
K
IIGS
M
K
E
--
A
L
H
P
E
I
D
GCEG
IL
NAMAR
PQ
T
AIVSLT
V
TEKGYC
A
D
A
A
S
G
Q
LD
L
N
NP
L
I
K
HDL
E
NP
TA
P
K
SA
I
G
Y
I
VEAL
RL
RRE
K
GLK
A
FTV
M
SCDN
V
RE
NGHV
A
K
V
AVLG
L
AQ
A
R
D
-
P
Q
-
LA
A
WI
E
E
N
V
T
FP
C
TMVDRIVPAAT
P
E
T
L
Q
EI
A
D
Q
LGV
Y
DPCAI
A
CEPF
R
QWVIE
-----------
DNFV
N
GRP
D
W
DKV
G
A
Q
F
V
A
DV
V
P
F
E
M
MKLRMLNGSHSFLAYLGYL
G
G
YE
TI
A
D
T
M
T
N
PDY
R
K
AA
FA
LM
M
Q
EQAPTL
S
M
P
E
G
T
DL
NA
YA
TL
LI
E
RF
S
NP
S
L
R
H
R
TWQIAMDGSQK
-----
LPQRLL
DP
V
R
L
HL
Q
NG
G
S
W
RH
LALGVAGWMRY
TQ
GVD
EQ
GNAIDV
V
DP
M
--
L
A
E
F
Q
K
I
N
AQ
YQ
-----
GA
D
RV
K
ALL
G
L
SGI
F
A
DDLPQN
A
D
FV
G
AV
TA
A
Y
QQ
L
C
E
R
GARE
C
V
A
AL
fig|386585.9.peg.5519
Escherichia coli O157:H7 str. Sakai (13-486/486)
R
PSWDHSR
L
E
SRIVH
L
G
C
GAFHRAHQAL
Y
T
H
H
LLE
S
TD
S
DWGICEV
N
L
MP
G
N
D
RV
L
IEN
L
KK
Q
QL
LYTV
A
-----
EKGA
ES
TE
L
K
IIGS
M
K
E
--
A
L
H
P
E
I
D
GCEG
IL
NAMAR
PQ
T
AIVSLT
V
TEKGYC
A
D
A
A
S
G
Q
LD
L
N
NP
L
I
K
HDL
E
NP
TA
P
K
SA
I
G
Y
I
VEAL
RL
RRE
K
GLK
A
FTV
M
SCDN
V
RE
NGHV
A
K
V
AVLG
L
AQ
A
R
D
-
P
Q
-
LA
A
WI
E
E
N
V
T
FP
C
TMVDRIVPAAT
P
E
T
L
Q
EI
A
D
Q
LGV
Y
DPCAI
A
CEPF
R
QWVIE
-----------
DNFV
N
GRP
D
W
DKV
G
A
Q
F
V
A
DV
V
P
F
E
M
MKLRMLNGSHSFLAYLGYL
G
G
YE
TI
A
D
T
M
T
N
PDY
R
K
AA
FA
LM
M
Q
EQAPTL
S
M
P
E
G
T
DL
NA
YA
TL
LI
E
RF
S
NP
S
L
R
H
R
TWQIAMDGSQK
-----
LPQRLL
DP
V
R
L
HL
Q
NG
G
S
W
RH
LALGVAGWMRY
TQ
GVD
EQ
GNAIDV
V
DP
M
--
L
A
E
F
Q
K
I
N
AQ
YQ
-----
GA
D
RV
K
ALL
G
L
SGI
F
A
DDLPQN
A
D
FV
G
AV
TA
A
Y
QQ
L
C
E
R
GARE
C
V
A
AL
fig|544404.4.peg.5470
Escherichia coli O157:H7 str. TW14359 (13-486/486)
R
PSWDHSR
L
E
SRIVH
L
G
C
GAFHRAHQAL
Y
T
H
H
LLE
S
TD
S
DWGICEV
N
L
MP
G
N
D
RV
L
IEN
L
KK
Q
QL
LYTV
A
-----
EKGA
ES
TE
L
K
IIGS
M
K
E
--
A
L
H
P
E
I
D
GCEG
IL
NAMAR
PQ
T
AIVSLT
V
TEKGYC
A
D
A
A
S
G
Q
LD
L
N
NP
L
I
K
HDL
E
NP
TA
P
K
SA
I
G
Y
I
VEAL
RL
RRE
K
GLK
A
FTV
M
SCDN
V
RE
NGHV
A
K
V
AVLG
L
AQ
A
R
D
-
P
Q
-
LA
A
WI
E
E
N
V
T
FP
C
TMVDRIVPAAT
P
E
T
L
Q
EI
A
D
Q
LGV
Y
DPCAI
A
CEPF
R
QWVIE
-----------
DNFV
N
GRP
D
W
DKV
G
A
Q
F
V
A
DV
V
P
F
E
M
MKLRMLNGSHSFLAYLGYL
G
G
YE
TI
A
D
T
M
T
N
PDY
R
K
AA
FA
LM
M
Q
EQAPTL
S
M
P
E
G
T
DL
NA
YA
TL
LI
E
RF
S
NP
S
L
R
H
R
TWQIAMDGSQK
-----
LPQRLL
DP
V
R
L
HL
Q
NG
G
S
W
RH
LALGVAGWMRY
TQ
GVD
EQ
GNAIDV
V
DP
M
--
L
A
E
F
Q
K
I
N
AQ
YQ
-----
GA
D
RV
K
ALL
G
L
SGI
F
A
DDLPQN
A
D
FV
G
AV
TA
A
Y
QQ
L
C
E
R
GARE
C
V
A
AL
fig|502346.5.peg.1352
Escherichia coli O157:H7 str. TW14588 (13-486/486)
R
PSWDHSR
L
E
SRIVH
L
G
C
GAFHRAHQAL
Y
T
H
H
LLE
S
TD
S
DWGICEV
N
L
MP
G
N
D
RV
L
IEN
L
KK
Q
QL
LYTV
A
-----
EKGA
ES
TE
L
K
IIGS
M
K
E
--
A
L
H
P
E
I
D
GCEG
IL
NAMAR
PQ
T
AIVSLT
V
TEKGYC
A
D
A
A
S
G
Q
LD
L
N
NP
L
I
K
HDL
E
NP
TA
P
K
SA
I
G
Y
I
VEAL
RL
RRE
K
GLK
A
FTV
M
SCDN
V
RE
NGHV
A
K
V
AVLG
L
AQ
A
R
D
-
P
Q
-
LA
A
WI
E
E
N
V
T
FP
C
TMVDRIVPAAT
P
E
T
L
Q
EI
A
D
Q
LGV
Y
DPCAI
A
CEPF
R
QWVIE
-----------
DNFV
N
GRP
D
W
DKV
G
A
Q
F
V
A
DV
V
P
F
E
M
MKLRMLNGSHSFLAYLGYL
G
G
YE
TI
A
D
T
M
T
N
PDY
R
K
AA
FA
LM
M
Q
EQAPTL
S
M
P
E
G
T
DL
NA
YA
TL
LI
E
RF
S
NP
S
L
R
H
R
TWQIAMDGSQK
-----
LPQRLL
DP
V
R
L
HL
Q
NG
G
S
W
RH
LALGVAGWMRY
TQ
GVD
EQ
GNAIDV
V
DP
M
--
L
A
E
F
Q
K
I
N
AQ
YQ
-----
GA
D
RV
K
ALL
G
L
SGI
F
A
DDLPQN
A
D
FV
G
AV
TA
A
Y
QQ
L
C
E
R
GARE
C
V
A
AL
fig|701177.3.peg.5129
Escherichia coli O55:H7 str. CB9615 (13-486/486)
R
PSWDHSR
L
E
SRIVH
L
G
C
GAFHRAHQAL
Y
T
H
H
LLE
S
TD
S
DWGICEV
N
L
MP
G
N
D
RV
L
IEN
L
KK
Q
QL
LYTV
A
-----
EKGA
ES
TE
L
K
IIGS
M
K
E
--
A
L
H
P
E
I
D
GCEG
IL
NAMAR
PQ
T
AIVSLT
V
TEKGYC
A
D
A
A
S
G
Q
LD
L
N
NP
L
I
K
HDL
E
NP
TA
P
K
SA
I
G
Y
I
VEAL
RL
RRE
K
GLK
A
FTV
M
SCDN
V
RE
NGHV
A
K
V
AVLG
L
AQ
A
R
D
-
P
Q
-
LA
A
WI
E
E
N
V
T
FP
C
TMVDRIVPAAT
P
E
T
L
Q
EI
A
D
Q
LGV
Y
DPCAI
A
CEPF
R
QWVIE
-----------
DNFV
N
GRP
D
W
DKV
G
A
Q
F
V
A
DV
V
P
F
E
M
MKLRMLNGSHSFLAYLGYL
G
G
YE
TI
A
D
T
M
T
N
PDY
R
K
AA
FA
LM
M
Q
EQAPTL
S
M
P
E
G
T
DL
NA
YA
TL
LI
E
RF
S
NP
S
L
R
H
R
TWQIAMDGSQK
-----
LPQRLL
DP
V
R
L
HL
Q
NG
G
S
W
RH
LALGVAGWMRY
TQ
GVD
EQ
GNAIDV
V
DP
M
--
L
A
E
F
Q
K
I
N
AQ
YQ
-----
GA
D
RV
K
ALL
G
L
SGI
F
A
DDLPQN
A
D
FV
G
AV
TA
A
Y
QQ
L
C
E
R
GARE
C
V
A
AL
fig|340185.3.peg.2059
Escherichia coli E22 (13-486/486)
R
PSWDHSR
L
E
SRIVH
L
G
C
GAFHRAHQAL
Y
T
H
H
LLE
S
TD
S
DWGICEV
N
L
MP
G
N
D
RV
L
IEN
L
KK
Q
QL
LYTV
A
-----
EKGA
ES
TE
L
K
IIGS
M
K
E
--
A
L
H
P
E
I
D
GCEG
IL
NAMAR
PQ
T
AIVSLT
V
TEKGYC
A
D
A
A
S
G
Q
LD
L
N
NP
L
I
K
HDL
E
NP
TA
P
K
SA
I
G
Y
I
VEAL
RL
RRE
K
GLK
A
FTV
M
SCDN
V
RE
NGHV
A
K
V
AVLG
L
AQ
A
R
D
-
P
Q
-
LA
A
WI
E
E
N
V
T
FP
C
TMVDRIVPAAT
P
E
T
L
Q
EI
A
D
Q
LGV
Y
DPCAI
A
CEPF
R
QWVIE
-----------
DNFV
N
GRP
D
W
DKV
G
A
Q
F
V
A
DV
V
P
F
E
M
MKLRMLNGSHSFLAYLGYL
G
G
YE
TI
A
D
T
M
T
N
PDY
R
K
AA
FS
LM
M
Q
EQAPTL
S
M
P
E
G
T
DL
NA
YA
TL
LI
E
RF
S
NP
S
L
R
H
R
TWQIAMDGSQK
-----
LPQRLL
DP
V
R
L
HL
Q
NG
G
S
W
RH
LALGVAGWMRY
TQ
GVD
EQ
GNAIDV
V
DP
M
--
L
A
E
F
Q
KV
N
AQ
YQ
-----
GA
D
RV
K
ALL
G
L
SGI
F
A
DDLPQN
A
D
FV
G
AV
TA
A
Y
QQ
L
C
E
R
GARE
C
V
A
AL
fig|340185.4.peg.2184
Escherichia coli E22 (13-486/486)
R
PSWDHSR
L
E
SRIVH
L
G
C
GAFHRAHQAL
Y
T
H
H
LLE
S
TD
S
DWGICEV
N
L
MP
G
N
D
RV
L
IEN
L
KK
Q
QL
LYTV
A
-----
EKGA
ES
TE
L
K
IIGS
M
K
E
--
A
L
H
P
E
I
D
GCEG
IL
NAMAR
PQ
T
AIVSLT
V
TEKGYC
A
D
A
A
S
G
Q
LD
L
N
NP
L
I
K
HDL
E
NP
TA
P
K
SA
I
G
Y
I
VEAL
RL
RRE
K
GLK
A
FTV
M
SCDN
V
RE
NGHV
A
K
V
AVLG
L
AQ
A
R
D
-
P
Q
-
LA
A
WI
E
E
N
V
T
FP
C
TMVDRIVPAAT
P
E
T
L
Q
EI
A
D
Q
LGV
Y
DPCAI
A
CEPF
R
QWVIE
-----------
DNFV
N
GRP
D
W
DKV
G
A
Q
F
V
A
DV
V
P
F
E
M
MKLRMLNGSHSFLAYLGYL
G
G
YE
TI
A
D
T
M
T
N
PDY
R
K
AA
FS
LM
M
Q
EQAPTL
S
M
P
E
G
T
DL
NA
YA
TL
LI
E
RF
S
NP
S
L
R
H
R
TWQIAMDGSQK
-----
LPQRLL
DP
V
R
L
HL
Q
NG
G
S
W
RH
LALGVAGWMRY
TQ
GVD
EQ
GNAIDV
V
DP
M
--
L
A
E
F
Q
KV
N
AQ
YQ
-----
GA
D
RV
K
ALL
G
L
SGI
F
A
DDLPQN
A
D
FV
G
AV
TA
A
Y
QQ
L
C
E
R
GARE
C
V
A
AL
fig|585395.4.peg.5365
Escherichia coli O103:H2 str. 12009 (13-486/486)
R
PSWDHSR
L
E
SRIVH
L
G
C
GAFHRAHQAL
Y
T
H
H
LLE
S
TD
S
DWGICEV
N
L
MP
G
N
D
RV
L
IEN
L
KK
Q
QL
LYTV
A
-----
EKGA
ES
TE
L
K
IIGS
M
K
E
--
A
L
H
P
E
I
D
GCEG
IL
NAMAR
PQ
T
AIVSLT
V
TEKGYC
A
D
A
A
S
G
Q
LD
L
N
NP
L
I
K
HDL
E
NP
TA
P
K
SA
I
G
Y
I
VEAL
RL
RRE
K
GLK
A
FTV
M
SCDN
V
RE
NGHV
A
K
V
AVLG
L
AQ
A
R
D
-
P
Q
-
LA
A
WI
E
E
N
V
T
FP
C
TMVDRIVPAAT
P
E
T
L
Q
EI
A
D
Q
LGV
Y
DPCAI
A
CEPF
R
QWVIE
-----------
DNFV
N
GRP
D
W
DKV
G
A
Q
F
V
A
DV
V
P
F
E
M
MKLRMLNGSHSFLAYLGYL
G
G
YE
TI
A
D
T
M
T
N
PDY
R
K
AA
FS
LM
M
Q
EQAPTL
S
M
P
E
G
T
DL
NA
YA
TL
LI
E
RF
S
NP
S
L
R
H
R
TWQIAMDGSQK
-----
LPQRLL
DP
V
R
L
HL
Q
NG
G
S
W
RH
LALGVAGWMRY
TQ
GVD
EQ
GNAIDV
V
DP
M
--
L
A
E
F
Q
KV
N
AQ
YQ
-----
GA
D
RV
K
ALL
G
L
SGI
F
A
DDLPQN
A
D
FV
G
AV
TA
A
Y
QQ
L
C
E
R
GARE
C
V
A
AL
fig|216592.1.peg.4507
Escherichia coli 042 (24-486/486)
RIVH
L
G
C
GAFHRAHQAL
Y
T
H
H
LLE
S
TD
S
DWGICEV
N
L
MP
G
N
D
RV
L
IEN
L
KK
Q
QL
LYTV
A
-----
EKGA
ES
TE
L
K
IIGS
M
K
E
--
A
L
H
P
E
I
D
GCEG
IL
NAMAR
PQ
T
AIVSLT
V
TEKGYC
A
D
A
A
S
G
Q
LD
L
N
NP
L
I
K
HDL
E
NP
TA
P
K
SA
I
G
Y
I
VEAL
RL
RRE
K
GLK
A
FTV
M
SCDN
V
RE
NGHV
A
K
V
AVLG
L
AQ
A
R
D
-
P
Q
-
LA
A
WI
E
E
N
V
T
FP
C
TMVDRIVPAAT
P
E
T
L
Q
EI
A
D
Q
LGV
Y
DPCAI
A
CEPF
R
QWVIE
-----------
DNFV
N
GRP
D
W
DKV
G
A
Q
F
V
A
DV
V
P
F
E
M
MKLRMLNGSHSFLAYLGYL
G
G
YE
TI
A
D
T
M
T
N
PDY
R
K
AA
FA
LM
M
Q
EQAPTL
S
M
P
E
G
T
DL
NA
YA
TL
LI
E
RF
S
NP
S
L
R
H
R
TWQIAMDGSQK
-----
LPQRLL
DP
V
R
L
HL
Q
NG
G
S
W
RH
LALGVAGWMRY
TQ
GVD
EQ
GNAIDV
V
DP
M
--
L
A
E
F
Q
K
I
N
AQ
YQ
-----
GA
D
RV
K
ALL
G
L
SGI
F
A
DDLPQN
A
D
FV
G
AV
TA
A
Y
QQ
L
C
E
R
GARE
C
V
A
AL
fig|216592.3.peg.5024
Escherichia coli 042 (24-486/486)
RIVH
L
G
C
GAFHRAHQAL
Y
T
H
H
LLE
S
TD
S
DWGICEV
N
L
MP
G
N
D
RV
L
IEN
L
KK
Q
QL
LYTV
A
-----
EKGA
ES
TE
L
K
IIGS
M
K
E
--
A
L
H
P
E
I
D
GCEG
IL
NAMAR
PQ
T
AIVSLT
V
TEKGYC
A
D
A
A
S
G
Q
LD
L
N
NP
L
I
K
HDL
E
NP
TA
P
K
SA
I
G
Y
I
VEAL
RL
RRE
K
GLK
A
FTV
M
SCDN
V
RE
NGHV
A
K
V
AVLG
L
AQ
A
R
D
-
P
Q
-
LA
A
WI
E
E
N
V
T
FP
C
TMVDRIVPAAT
P
E
T
L
Q
EI
A
D
Q
LGV
Y
DPCAI
A
CEPF
R
QWVIE
-----------
DNFV
N
GRP
D
W
DKV
G
A
Q
F
V
A
DV
V
P
F
E
M
MKLRMLNGSHSFLAYLGYL
G
G
YE
TI
A
D
T
M
T
N
PDY
R
K
AA
FA
LM
M
Q
EQAPTL
S
M
P
E
G
T
DL
NA
YA
TL
LI
E
RF
S
NP
S
L
R
H
R
TWQIAMDGSQK
-----
LPQRLL
DP
V
R
L
HL
Q
NG
G
S
W
RH
LALGVAGWMRY
TQ
GVD
EQ
GNAIDV
V
DP
M
--
L
A
E
F
Q
K
I
N
AQ
YQ
-----
GA
D
RV
K
ALL
G
L
SGI
F
A
DDLPQN
A
D
FV
G
AV
TA
A
Y
QQ
L
C
E
R
GARE
C
V
A
AL
fig|331111.12.peg.5123
Escherichia coli E24377A (24-486/486)
RIVH
L
G
C
GAFHRAHQAL
Y
T
H
H
LLE
S
TD
S
DWGICEV
N
L
MP
G
N
D
RV
L
IEN
L
KK
Q
QL
LYTV
A
-----
EKGA
ES
TE
L
K
IIGS
M
K
E
--
A
L
H
P
E
I
D
GCEG
IL
NAMAR
PQ
T
AIVSLT
V
TEKGYC
A
D
A
A
S
G
Q
LD
L
N
NP
L
I
K
HDL
E
NP
TA
P
K
SA
I
G
Y
I
VEAL
RL
RRE
K
GLK
A
FTV
M
SCDN
V
RE
NGHV
A
K
V
AVLG
L
AQ
A
R
D
-
P
Q
-
LA
A
WI
E
E
N
V
T
FP
C
TMVDRIVPAAT
P
E
T
L
Q
EI
A
D
Q
LGV
Y
DPCAI
A
CEPF
R
QWVIE
-----------
DNFV
N
GRP
D
W
DKV
G
A
Q
F
V
A
DV
V
P
F
E
M
MKLRMLNGSHSFLAYLGYL
G
G
YE
TI
A
D
T
M
T
N
PDY
R
K
AA
FA
LM
M
Q
EQAPTL
S
M
P
E
G
T
DL
NA
YA
TL
LI
E
RF
S
NP
S
L
R
H
R
TWQIAMDGSQK
-----
LPQRLL
DP
V
R
L
HL
Q
NG
G
S
W
RH
LALGVAGWMRY
TQ
GVD
EQ
GNAIDV
V
DP
M
--
L
A
E
F
Q
K
I
N
AQ
YQ
-----
GA
D
RV
K
ALL
G
L
SGI
F
A
DDLPQN
A
D
FV
G
AV
TA
A
Y
QQ
L
C
E
R
GARE
C
V
A
AL
fig|331111.3.peg.2501
Escherichia coli E24377A (24-486/486)
RIVH
L
G
C
GAFHRAHQAL
Y
T
H
H
LLE
S
TD
S
DWGICEV
N
L
MP
G
N
D
RV
L
IEN
L
KK
Q
QL
LYTV
A
-----
EKGA
ES
TE
L
K
IIGS
M
K
E
--
A
L
H
P
E
I
D
GCEG
IL
NAMAR
PQ
T
AIVSLT
V
TEKGYC
A
D
A
A
S
G
Q
LD
L
N
NP
L
I
K
HDL
E
NP
TA
P
K
SA
I
G
Y
I
VEAL
RL
RRE
K
GLK
A
FTV
M
SCDN
V
RE
NGHV
A
K
V
AVLG
L
AQ
A
R
D
-
P
Q
-
LA
A
WI
E
E
N
V
T
FP
C
TMVDRIVPAAT
P
E
T
L
Q
EI
A
D
Q
LGV
Y
DPCAI
A
CEPF
R
QWVIE
-----------
DNFV
N
GRP
D
W
DKV
G
A
Q
F
V
A
DV
V
P
F
E
M
MKLRMLNGSHSFLAYLGYL
G
G
YE
TI
A
D
T
M
T
N
PDY
R
K
AA
FA
LM
M
Q
EQAPTL
S
M
P
E
G
T
DL
NA
YA
TL
LI
E
RF
S
NP
S
L
R
H
R
TWQIAMDGSQK
-----
LPQRLL
DP
V
R
L
HL
Q
NG
G
S
W
RH
LALGVAGWMRY
TQ
GVD
EQ
GNAIDV
V
DP
M
--
L
A
E
F
Q
K
I
N
AQ
YQ
-----
GA
D
RV
K
ALL
G
L
SGI
F
A
DDLPQN
A
D
FV
G
AV
TA
A
Y
QQ
L
C
E
R
GARE
C
V
A
AL
fig|749537.3.peg.343
Escherichia coli MS 115-1 (24-486/486)
RIVH
L
G
C
GAFHRAHQAL
Y
T
H
H
LLE
S
TD
S
DWGICEV
N
L
MP
G
N
D
RV
L
IEN
L
KK
Q
QL
LYTV
A
-----
EKGA
ES
TE
L
K
IIGS
M
K
E
--
A
L
H
P
E
I
D
GCEG
IL
NAMAR
PQ
T
AIVSLT
V
TEKGYC
A
D
A
A
S
G
Q
LD
L
N
NP
L
I
K
HDL
E
NP
TA
P
K
SA
I
G
Y
I
VEAL
RL
RRE
K
GLK
A
FTV
M
SCDN
V
RE
NGHV
A
K
V
AVLG
L
AQ
A
R
D
-
P
Q
-
LA
A
WI
E
E
N
V
T
FP
C
TMVDRIVPAAT
P
E
T
L
Q
EI
A
D
Q
LGV
Y
DPCAI
A
CEPF
R
QWVIE
-----------
DNFV
N
GRP
D
W
DKV
G
A
Q
F
V
A
DV
V
P
F
E
M
MKLRMLNGSHSFLAYLGYL
G
G
YE
TI
A
D
T
M
T
N
PDY
R
K
AA
FA
LM
M
Q
EQAPTL
S
M
P
E
G
T
DL
NA
YA
TL
LI
E
RF
S
NP
S
L
R
H
R
TWQIAMDGSQK
-----
LPQRLL
DP
V
R
L
HL
Q
NG
G
S
W
RH
LALGVAGWMRY
TQ
GVD
EQ
GNAIDV
V
DP
M
--
L
A
E
F
Q
K
I
N
AQ
YQ
-----
GA
D
RV
K
ALL
G
L
SGI
F
A
DDLPQN
A
D
FV
G
AV
TA
A
Y
QQ
L
C
E
R
GARE
C
V
A
AL
fig|749538.3.peg.2271
Escherichia coli MS 116-1 (24-486/486)
RIVH
L
G
C
GAFHRAHQAL
Y
T
H
H
LLE
S
TD
S
DWGICEV
N
L
MP
G
N
D
RV
L
IEN
L
KK
Q
QL
LYTV
A
-----
EKGA
ES
TE
L
K
IIGS
M
K
E
--
A
L
H
P
E
I
D
GCEG
IL
NAMAR
PQ
T
AIVSLT
V
TEKGYC
A
D
A
A
S
G
Q
LD
L
N
NP
L
I
K
HDL
E
NP
TA
P
K
SA
I
G
Y
I
VEAL
RL
RRE
K
GLK
A
FTV
M
SCDN
V
RE
NGHV
A
K
V
AVLG
L
AQ
A
R
D
-
P
Q
-
LA
A
WI
E
E
N
V
T
FP
C
TMVDRIVPAAT
P
E
T
L
Q
EI
A
D
Q
LGV
Y
DPCAI
A
CEPF
R
QWVIE
-----------
DNFV
N
GRP
D
W
DKV
G
A
Q
F
V
A
DV
V
P
F
E
M
MKLRMLNGSHSFLAYLGYL
G
G
YE
TI
A
D
T
M
T
N
PDY
R
K
AA
FA
LM
M
Q
EQAPTL
S
M
P
E
G
T
DL
NA
YA
TL
LI
E
RF
S
NP
S
L
R
H
R
TWQIAMDGSQK
-----
LPQRLL
DP
V
R
L
HL
Q
NG
G
S
W
RH
LALGVAGWMRY
TQ
GVD
EQ
GNAIDV
V
DP
M
--
L
A
E
F
Q
K
I
N
AQ
YQ
-----
GA
D
RV
K
ALL
G
L
SGI
F
A
DDLPQN
A
D
FV
G
AV
TA
A
Y
QQ
L
C
E
R
GARE
C
V
A
AL
fig|749544.3.peg.791
Escherichia coli MS 175-1 (24-486/486)
RIVH
L
G
C
GAFHRAHQAL
Y
T
H
H
LLE
S
TD
S
DWGICEV
N
L
MP
G
N
D
RV
L
IEN
L
KK
Q
QL
LYTV
A
-----
EKGA
ES
TE
L
K
IIGS
M
K
E
--
A
L
H
P
E
I
D
GCEG
IL
NAMAR
PQ
T
AIVSLT
V
TEKGYC
A
D
A
A
S
G
Q
LD
L
N
NP
L
I
K
HDL
E
NP
TA
P
K
SA
I
G
Y
I
VEAL
RL
RRE
K
GLK
A
FTV
M
SCDN
V
RE
NGHV
A
K
V
AVLG
L
AQ
A
R
D
-
P
Q
-
LA
A
WI
E
E
N
V
T
FP
C
TMVDRIVPAAT
P
E
T
L
Q
EI
A
D
Q
LGV
Y
DPCAI
A
CEPF
R
QWVIE
-----------
DNFV
N
GRP
D
W
DKV
G
A
Q
F
V
A
DV
V
P
F
E
M
MKLRMLNGSHSFLAYLGYL
G
G
YE
TI
A
D
T
M
T
N
PDY
R
K
AA
FA
LM
M
Q
EQAPTL
S
M
P
E
G
T
DL
NA
YA
TL
LI
E
RF
S
NP
S
L
R
H
R
TWQIAMDGSQK
-----
LPQRLL
DP
V
R
L
HL
Q
NG
G
S
W
RH
LALGVAGWMRY
TQ
GVD
EQ
GNAIDV
V
DP
M
--
L
A
E
F
Q
K
I
N
AQ
YQ
-----
GA
D
RV
K
ALL
G
L
SGI
F
A
DDLPQN
A
D
FV
G
AV
TA
A
Y
QQ
L
C
E
R
GARE
C
V
A
AL
fig|573235.3.peg.5708
Escherichia coli O26:H11 str. 11368 (13-486/486)
R
PSW
E
HSR
L
E
SRIVH
L
G
C
GAFHRAHQAL
Y
T
H
H
LLE
S
TD
S
DWGICEV
N
L
MP
G
N
D
RV
L
IEN
L
KK
Q
QL
LYTV
A
-----
EKGA
ES
TE
L
K
IIGS
M
K
E
--
A
L
H
P
E
I
D
GCEG
IL
NAMAR
PQ
T
AIVSLT
V
TEKGYC
A
D
A
A
S
G
Q
LD
L
N
NP
L
I
K
HDL
E
NP
TA
P
K
SA
I
G
Y
I
VEAL
RL
RRE
K
GLK
A
FTV
M
SCDN
V
RE
NGHV
A
K
V
AVLG
L
AQ
A
R
D
-
P
Q
-
LA
A
WI
E
E
N
V
T
FP
C
TMVDRIVPAAT
P
E
T
L
Q
EI
A
D
Q
LGV
Y
DPCAI
A
CEPF
R
QWVIE
-----------
DNFV
N
GRP
D
W
DKV
G
A
Q
F
V
A
DV
V
P
F
E
M
MKLRMLNGSHSFLAYLGYL
G
G
YE
TI
A
D
T
M
T
N
PDY
R
K
AA
FS
LM
M
Q
EQAPTL
S
M
P
E
G
T
DL
NA
YA
TL
LI
E
RF
S
NP
S
L
R
H
R
TWQIAMDGSQK
-----
LPQRLL
DP
V
R
L
HL
Q
NG
G
S
W
RH
LALGVAGWMRY
TQ
GVD
EQ
GNAIDV
V
DP
M
--
L
A
E
F
Q
KV
N
AQ
YQ
-----
GA
D
RV
K
ALL
G
L
SGI
F
A
DDLPQN
A
D
F
I
G
AV
TA
A
Y
QQ
L
C
E
R
GARE
C
V
A
AL
fig|439855.10.peg.4948
Escherichia coli SMS-3-5 (13-486/486)
R
PSWDHSR
L
E
SRIVH
L
G
C
GAFHRAHQAL
Y
T
H
H
LLE
S
TD
S
DWGICEV
N
L
MP
G
N
D
RV
L
IEN
L
KK
Q
QL
LYTV
A
-----
EKGA
ES
TE
L
K
IIGS
M
K
E
--
A
L
H
P
E
I
D
GCEG
IL
NAMAR
PQ
T
AIVSLT
V
TEKGYC
A
D
A
A
S
G
Q
LD
L
N
NP
L
I
K
HDL
E
NP
TA
P
K
SA
I
G
Y
I
VEAL
RL
RRE
K
GLK
A
FTV
M
SCDN
V
RE
NGHV
A
K
V
AVLG
L
AQ
A
R
D
-
P
Q
-
LA
A
WI
E
E
N
V
T
FP
C
TMVDRIVPAAT
P
E
T
L
Q
EI
A
D
Q
LGV
Y
DPCAI
A
CEPF
R
QWVIE
-----------
DNFV
N
GRP
D
W
DKV
G
A
Q
F
V
A
DV
V
P
F
E
M
MKLRMLNGSHSFLAYLGYL
G
G
YE
TI
A
D
T
M
T
N
PDY
R
K
AA
FA
LM
M
Q
EQAPTL
S
M
P
E
G
T
DL
NA
YA
TL
LI
E
RF
S
NP
S
L
R
H
R
TWQIAMDGSQK
-----
LPQRLL
DP
V
R
L
HL
Q
NG
G
S
W
RH
LALGVAGWMRY
TQ
GVD
EQ
GNAIDV
V
DP
M
--
L
V
E
F
Q
K
I
N
AQ
YQ
-----
GA
D
RV
K
ALL
G
L
SGI
F
A
DDLPQN
A
D
FV
G
AV
TA
A
Y
QQ
L
C
E
R
GARE
C
V
A
AL
fig|562.375.peg.2758
Escherichia coli EC4100B (13-486/486)
R
PSWDHSR
L
E
SRIVH
L
G
C
GAFHRAHQAL
Y
T
H
H
LLE
S
TD
S
DWGICEV
N
L
MP
G
N
D
RV
L
IEN
L
KK
Q
QL
LYTV
A
-----
EKGA
ES
TE
L
K
IIGS
M
K
E
--
A
L
H
P
E
I
D
GCEG
IL
NAMAR
PQ
T
AIVSLT
V
TEKGYC
A
D
A
A
S
G
Q
LD
L
N
NP
L
I
K
HDL
E
NP
TA
P
K
SA
I
G
Y
I
VEAL
RL
RRE
K
GLK
A
FTV
M
SCDN
V
RE
NGHV
A
K
V
AVLG
L
AQ
A
R
D
-
P
Q
-
LA
A
WI
E
E
N
V
T
FP
C
TMVDRIVPAAT
P
E
T
L
Q
EI
A
D
Q
LGV
Y
DPCAI
A
CEPF
R
QWVIE
-----------
DNFV
N
GRP
D
W
DKV
G
A
Q
F
V
A
DV
V
P
F
E
M
MKLRMLNGSHSFLAYLGYL
G
G
YE
TI
A
D
T
M
T
N
PAY
R
K
AA
FS
LM
M
Q
EQAPTL
S
M
P
E
G
T
DL
NA
YA
TL
LI
E
RF
S
NP
S
L
R
H
R
TWQIAMDGSQK
-----
LPQRLL
DP
V
R
L
HL
Q
NG
G
S
W
RH
LALGVAGWMRY
TQ
GVD
EQ
GNAIDV
V
DP
M
--
L
A
E
F
Q
K
I
N
AQ
YQ
-----
GA
D
RV
K
ALL
G
L
SGI
F
A
DDLPQN
A
D
FV
G
AV
TA
A
Y
QQ
L
C
E
R
GARE
C
V
A
AL
fig|585057.4.peg.4942
Escherichia coli IAI39 (13-486/486)
R
PSWDHSR
L
E
SRIVH
L
G
C
GAFHRAHQAL
Y
T
H
H
LLE
S
TD
S
DWGICEV
N
L
MP
G
N
D
RV
L
IEN
L
KK
Q
QL
LYTV
A
-----
EKGA
ES
TE
L
K
IIGS
M
K
E
--
A
L
H
P
E
I
D
GCEG
IL
NAMAR
PQ
T
AIVSLT
V
TEKGYC
A
D
A
A
S
G
Q
LD
L
N
NP
L
I
K
HDL
E
NP
TA
P
K
SA
I
G
Y
I
VEAL
RL
RRE
K
GLK
A
FTV
M
SCDN
V
RE
NGHV
A
K
V
AVLG
L
AQ
A
R
D
-
P
Q
-
LA
A
WI
E
E
N
V
T
FP
C
TMVDRIVPAAT
P
E
T
L
Q
EI
A
D
Q
LGV
Y
DPCAI
A
CEPF
R
QWVIE
-----------
DNFV
N
GRP
D
W
DKV
G
A
Q
F
V
A
DV
V
P
F
E
M
MKLRMLNGSHSFLAYLGYL
G
G
YE
TI
A
D
T
M
T
N
PAY
R
K
AA
FS
LM
M
Q
EQAPTL
S
M
P
E
G
T
DL
NA
YA
TL
LI
E
RF
S
NP
S
L
R
H
R
TWQIAMDGSQK
-----
LPQRLL
DP
V
R
L
HL
Q
NG
G
S
W
RH
LALGVAGWMRY
TQ
GVD
EQ
GNAIDV
V
DP
M
--
L
A
E
F
Q
K
I
N
AQ
YQ
-----
GA
D
RV
K
ALL
G
L
SGI
F
A
DDLPQN
A
D
FV
G
AV
TA
A
Y
QQ
L
C
E
R
GARE
C
V
A
AL
fig|585057.6.peg.4951
Escherichia coli IAI39 (13-486/486)
R
PSWDHSR
L
E
SRIVH
L
G
C
GAFHRAHQAL
Y
T
H
H
LLE
S
TD
S
DWGICEV
N
L
MP
G
N
D
RV
L
IEN
L
KK
Q
QL
LYTV
A
-----
EKGA
ES
TE
L
K
IIGS
M
K
E
--
A
L
H
P
E
I
D
GCEG
IL
NAMAR
PQ
T
AIVSLT
V
TEKGYC
A
D
A
A
S
G
Q
LD
L
N
NP
L
I
K
HDL
E
NP
TA
P
K
SA
I
G
Y
I
VEAL
RL
RRE
K
GLK
A
FTV
M
SCDN
V
RE
NGHV
A
K
V
AVLG
L
AQ
A
R
D
-
P
Q
-
LA
A
WI
E
E
N
V
T
FP
C
TMVDRIVPAAT
P
E
T
L
Q
EI
A
D
Q
LGV
Y
DPCAI
A
CEPF
R
QWVIE
-----------
DNFV
N
GRP
D
W
DKV
G
A
Q
F
V
A
DV
V
P
F
E
M
MKLRMLNGSHSFLAYLGYL
G
G
YE
TI
A
D
T
M
T
N
PAY
R
K
AA
FS
LM
M
Q
EQAPTL
S
M
P
E
G
T
DL
NA
YA
TL
LI
E
RF
S
NP
S
L
R
H
R
TWQIAMDGSQK
-----
LPQRLL
DP
V
R
L
HL
Q
NG
G
S
W
RH
LALGVAGWMRY
TQ
GVD
EQ
GNAIDV
V
DP
M
--
L
A
E
F
Q
K
I
N
AQ
YQ
-----
GA
D
RV
K
ALL
G
L
SGI
F
A
DDLPQN
A
D
FV
G
AV
TA
A
Y
QQ
L
C
E
R
GARE
C
V
A
AL
fig|595495.4.peg.2110
Escherichia coli KO11 (13-486/486)
R
PSWDHSR
L
E
SRIVH
L
G
C
GAFHRAHQAL
Y
T
H
H
LLE
S
TD
S
DWGICEV
N
L
MP
G
N
D
RV
L
IEN
L
KK
Q
QL
LYTV
A
-----
EKGA
ES
TE
L
K
IIGS
M
K
E
--
A
L
H
P
E
I
D
GCEG
IL
NAMAR
PQ
T
AIVSLT
V
TEKGYC
A
D
A
A
S
G
Q
LD
L
N
NP
L
I
K
HDL
E
NP
TA
P
K
SA
I
G
Y
I
VEAL
RL
RRE
K
GLK
A
FTV
M
SCDN
V
RE
NGHV
A
K
V
AVLG
L
AQ
A
R
D
-
P
Q
-
LA
A
WI
E
E
N
V
T
FP
C
TMVDRIVPAAT
P
E
T
L
Q
EI
A
D
Q
LGV
Y
DPCAI
A
CEPF
R
QWVIE
-----------
DNFV
K
GRP
D
W
DKV
G
A
Q
F
V
A
DV
V
P
F
E
M
MKLRMLNGSHSFLAYLGYL
G
G
YE
TI
A
D
T
M
T
N
PAY
R
K
AA
FS
LM
M
Q
EQAPTL
S
M
P
E
G
T
DL
NA
YA
TL
LI
E
RF
S
NP
S
L
R
H
R
TWQIAM
E
GSQK
-----
LPQRLL
DP
V
R
L
HL
Q
NG
G
S
W
RH
LALGVAGWMRY
TQ
GVD
EQ
GNAIDV
V
DP
M
--
L
A
E
F
Q
K
I
N
AQ
YQ
-----
GA
D
RV
K
ALL
G
L
SGI
F
A
DDLPQN
A
D
FV
G
AV
TA
A
Y
QQ
L
C
E
R
GARE
C
V
A
AL
fig|566546.3.peg.4952
Escherichia coli W (13-486/486)
R
PSWDHSR
L
E
SRIVH
L
G
C
GAFHRAHQAL
Y
T
H
H
LLE
S
TD
S
DWGICEV
N
L
MP
G
N
D
RV
L
IEN
L
KK
Q
QL
LYTV
A
-----
EKGA
ES
TE
L
K
IIGS
M
K
E
--
A
L
H
P
E
I
D
GCEG
IL
NAMAR
PQ
T
AIVSLT
V
TEKGYC
A
D
A
A
S
G
Q
LD
L
N
NP
L
I
K
HDL
E
NP
TA
P
K
SA
I
G
Y
I
VEAL
RL
RRE
K
GLK
A
FTV
M
SCDN
V
RE
NGHV
A
K
V
AVLG
L
AQ
A
R
D
-
P
Q
-
LA
A
WI
E
E
N
V
T
FP
C
TMVDRIVPAAT
P
E
T
L
Q
EI
A
D
Q
LGV
Y
DPCAI
A
CEPF
R
QWVIE
-----------
DNFV
K
GRP
D
W
DKV
G
A
Q
F
V
A
DV
V
P
F
E
M
MKLRMLNGSHSFLAYLGYL
G
G
YE
TI
A
D
T
M
T
N
PAY
R
K
AA
FS
LM
M
Q
EQAPTL
S
M
P
E
G
T
DL
NA
YA
TL
LI
E
RF
S
NP
S
L
R
H
R
TWQIAM
E
GSQK
-----
LPQRLL
DP
V
R
L
HL
Q
NG
G
S
W
RH
LALGVAGWMRY
TQ
GVD
EQ
GNAIDV
V
DP
M
--
L
A
E
F
Q
K
I
N
AQ
YQ
-----
GA
D
RV
K
ALL
G
L
SGI
F
A
DDLPQN
A
D
FV
G
AV
TA
A
Y
QQ
L
C
E
R
GARE
C
V
A
AL
fig|566546.4.peg.4620
Escherichia coli W (13-486/486)
R
PSWDHSR
L
E
SRIVH
L
G
C
GAFHRAHQAL
Y
T
H
H
LLE
S
TD
S
DWGICEV
N
L
MP
G
N
D
RV
L
IEN
L
KK
Q
QL
LYTV
A
-----
EKGA
ES
TE
L
K
IIGS
M
K
E
--
A
L
H
P
E
I
D
GCEG
IL
NAMAR
PQ
T
AIVSLT
V
TEKGYC
A
D
A
A
S
G
Q
LD
L
N
NP
L
I
K
HDL
E
NP
TA
P
K
SA
I
G
Y
I
VEAL
RL
RRE
K
GLK
A
FTV
M
SCDN
V
RE
NGHV
A
K
V
AVLG
L
AQ
A
R
D
-
P
Q
-
LA
A
WI
E
E
N
V
T
FP
C
TMVDRIVPAAT
P
E
T
L
Q
EI
A
D
Q
LGV
Y
DPCAI
A
CEPF
R
QWVIE
-----------
DNFV
K
GRP
D
W
DKV
G
A
Q
F
V
A
DV
V
P
F
E
M
MKLRMLNGSHSFLAYLGYL
G
G
YE
TI
A
D
T
M
T
N
PAY
R
K
AA
FS
LM
M
Q
EQAPTL
S
M
P
E
G
T
DL
NA
YA
TL
LI
E
RF
S
NP
S
L
R
H
R
TWQIAM
E
GSQK
-----
LPQRLL
DP
V
R
L
HL
Q
NG
G
S
W
RH
LALGVAGWMRY
TQ
GVD
EQ
GNAIDV
V
DP
M
--
L
A
E
F
Q
K
I
N
AQ
YQ
-----
GA
D
RV
K
ALL
G
L
SGI
F
A
DDLPQN
A
D
FV
G
AV
TA
A
Y
QQ
L
C
E
R
GARE
C
V
A
AL
fig|362663.8.peg.4677
Escherichia coli 536 (13-486/486)
R
PSWDHSR
L
E
SRIVH
L
G
C
GAFHRAHQAL
Y
T
H
H
LLE
S
TD
S
DWGICEV
N
L
MP
G
N
D
RV
L
IEN
L
KK
Q
QL
LYTV
A
-----
EKGA
ES
TE
L
K
IIGS
M
K
E
--
A
L
H
P
E
I
D
GCEG
IL
NAMAR
PQ
T
AIVSLT
V
TEKGYC
A
D
A
A
S
G
Q
LD
L
N
NP
L
I
K
HDL
E
NP
TA
P
K
SA
I
G
Y
I
VEAL
RL
RRE
K
GLK
A
FTV
M
SCDN
V
RE
NGHV
A
K
V
AVLG
L
AQ
A
R
D
-
P
Q
-
LA
A
WI
E
E
N
V
T
FP
C
TMVDRIVPAAT
P
E
T
L
Q
EI
A
D
Q
LGV
Y
DPCAI
A
CEPF
R
QWVIE
-----------
DNFV
N
GRP
D
W
DKV
G
A
Q
F
V
A
DV
V
P
F
E
M
MKLRMLNGSHSFLAYLGYL
G
G
YE
TI
A
D
T
M
T
N
PAY
R
K
AA
FA
LM
M
Q
EQAPTL
S
M
P
E
G
T
DL
NA
YA
TL
LI
E
RF
S
NP
S
L
R
H
R
TWQIAMDGSQK
-----
LPQRLL
DP
V
R
L
HL
Q
NG
G
S
W
RH
LALGVAGWMRY
TQ
GVD
EQ
GNAIDV
V
DP
M
--
L
A
E
F
Q
K
I
N
AQ
YQ
-----
GA
D
RV
K
ALL
G
L
SGI
F
A
DDLPQN
A
D
FV
G
AV
TA
A
Y
QQ
L
C
E
R
GARE
C
V
A
AL
fig|362663.9.peg.4693
Escherichia coli 536 (13-486/486)
R
PSWDHSR
L
E
SRIVH
L
G
C
GAFHRAHQAL
Y
T
H
H
LLE
S
TD
S
DWGICEV
N
L
MP
G
N
D
RV
L
IEN
L
KK
Q
QL
LYTV
A
-----
EKGA
ES
TE
L
K
IIGS
M
K
E
--
A
L
H
P
E
I
D
GCEG
IL
NAMAR
PQ
T
AIVSLT
V
TEKGYC
A
D
A
A
S
G
Q
LD
L
N
NP
L
I
K
HDL
E
NP
TA
P
K
SA
I
G
Y
I
VEAL
RL
RRE
K
GLK
A
FTV
M
SCDN
V
RE
NGHV
A
K
V
AVLG
L
AQ
A
R
D
-
P
Q
-
LA
A
WI
E
E
N
V
T
FP
C
TMVDRIVPAAT
P
E
T
L
Q
EI
A
D
Q
LGV
Y
DPCAI
A
CEPF
R
QWVIE
-----------
DNFV
N
GRP
D
W
DKV
G
A
Q
F
V
A
DV
V
P
F
E
M
MKLRMLNGSHSFLAYLGYL
G
G
YE
TI
A
D
T
M
T
N
PAY
R
K
AA
FA
LM
M
Q
EQAPTL
S
M
P
E
G
T
DL
NA
YA
TL
LI
E
RF
S
NP
S
L
R
H
R
TWQIAMDGSQK
-----
LPQRLL
DP
V
R
L
HL
Q
NG
G
S
W
RH
LALGVAGWMRY
TQ
GVD
EQ
GNAIDV
V
DP
M
--
L
A
E
F
Q
K
I
N
AQ
YQ
-----
GA
D
RV
K
ALL
G
L
SGI
F
A
DDLPQN
A
D
FV
G
AV
TA
A
Y
QQ
L
C
E
R
GARE
C
V
A
AL
fig|550672.3.peg.4633
Escherichia coli B088 (13-486/486)
R
PSWDHSR
L
E
SRIVH
L
G
C
GAFHRAHQAL
Y
T
H
H
LLE
S
TD
S
DWGICEV
N
L
MP
G
N
D
RV
L
IEN
L
KK
Q
QL
LYTV
A
-----
EKGA
ES
TE
L
K
IIGS
M
K
E
--
A
L
H
P
E
I
D
GCEG
IL
NAMAR
PQ
T
AIVSLT
V
TEKGYC
A
D
A
A
S
G
Q
LD
L
N
NP
L
I
K
HDL
E
NP
TA
P
K
SA
I
G
Y
I
VEAL
RL
RRE
K
GLK
A
FTV
M
SCDN
V
RE
NGHV
A
K
V
AVLG
L
AQ
A
R
D
-
P
Q
-
LA
A
WI
E
E
N
V
T
FP
C
TMVDRIVPAAT
P
E
T
L
Q
EI
A
D
Q
LGV
Y
DPCAI
A
CEPF
R
QWVIE
-----------
DNFV
N
GRP
D
W
DKV
G
A
Q
F
V
A
DV
V
P
F
E
M
MKLRMLNGSHSFLAYLGYL
G
G
YE
TI
A
D
T
M
T
N
PAY
R
K
AA
FA
LM
M
Q
EQAPTL
S
M
P
E
G
T
DL
NA
YA
TL
LI
E
RF
S
NP
S
L
R
H
R
TWQIAMDGSQK
-----
LPQRLL
DP
V
R
L
HL
Q
NG
G
S
W
RH
LALGVAGWMRY
TQ
GVD
EQ
GNAIDV
V
DP
M
--
L
A
E
F
Q
K
I
N
AQ
YQ
-----
GA
D
RV
K
ALL
G
L
SGI
F
A
DDLPQN
A
D
FV
G
AV
TA
A
Y
QQ
L
C
E
R
GARE
C
V
A
AL
fig|216593.1.peg.3667
Escherichia coli E2348/69 (13-486/486)
R
PSWDHSR
L
E
SRIVH
L
G
C
GAFHRAHQAL
Y
T
H
H
LLE
S
TD
S
DWGICEV
N
L
MP
G
N
D
RV
L
IEN
L
KK
Q
QL
LYTV
A
-----
EKGA
ES
TE
L
K
IIGS
M
K
E
--
A
L
H
P
E
I
D
GCEG
IL
NAMAR
PQ
T
AIVSLT
V
TEKGYC
A
D
A
A
S
G
Q
LD
L
N
NP
L
I
K
HDL
E
NP
TA
P
K
SA
I
G
Y
I
VEAL
RL
RRE
K
GLK
A
FTV
M
SCDN
V
RE
NGHV
A
K
V
AVLG
L
AQ
A
R
D
-
P
Q
-
LA
A
WI
E
E
N
V
T
FP
C
TMVDRIVPAAT
P
E
T
L
Q
EI
A
D
Q
LGV
Y
DPCAI
A
CEPF
R
QWVIE
-----------
DNFV
N
GRP
D
W
DKV
G
A
Q
F
V
A
DV
V
P
F
E
M
MKLRMLNGSHSFLAYLGYL
G
G
YE
TI
A
D
T
M
T
N
PAY
R
K
AA
FA
LM
M
Q
EQAPTL
S
M
P
E
G
T
DL
NA
YA
TL
LI
E
RF
S
NP
S
L
R
H
R
TWQIAMDGSQK
-----
LPQRLL
DP
V
R
L
HL
Q
NG
G
S
W
RH
LALGVAGWMRY
TQ
GVD
EQ
GNAIDV
V
DP
M
--
L
A
E
F
Q
K
I
N
AQ
YQ
-----
GA
D
RV
K
ALL
G
L
SGI
F
A
DDLPQN
A
D
FV
G
AV
TA
A
Y
QQ
L
C
E
R
GARE
C
V
A
AL
fig|585397.7.peg.5176
Escherichia coli ED1a (13-486/486)
R
PSWDHSR
L
E
SRIVH
L
G
C
GAFHRAHQAL
Y
T
H
H
LLE
S
TD
S
DWGICEV
N
L
MP
G
N
D
RV
L
IEN
L
KK
Q
QL
LYTV
A
-----
EKGA
ES
TE
L
K
IIGS
M
K
E
--
A
L
H
P
E
I
D
GCEG
IL
NAMAR
PQ
T
AIVSLT
V
TEKGYC
A
D
A
A
S
G
Q
LD
L
N
NP
L
I
K
HDL
E
NP
TA
P
K
SA
I
G
Y
I
VEAL
RL
RRE
K
GLK
A
FTV
M
SCDN
V
RE
NGHV
A
K
V
AVLG
L
AQ
A
R
D
-
P
Q
-
LA
A
WI
E
E
N
V
T
FP
C
TMVDRIVPAAT
P
E
T
L
Q
EI
A
D
Q
LGV
Y
DPCAI
A
CEPF
R
QWVIE
-----------
DNFV
N
GRP
D
W
DKV
G
A
Q
F
V
A
DV
V
P
F
E
M
MKLRMLNGSHSFLAYLGYL
G
G
YE
TI
A
D
T
M
T
N
PAY
R
K
AA
FA
LM
M
Q
EQAPTL
S
M
P
E
G
T
DL
NA
YA
TL
LI
E
RF
S
NP
S
L
R
H
R
TWQIAMDGSQK
-----
LPQRLL
DP
V
R
L
HL
Q
NG
G
S
W
RH
LALGVAGWMRY
TQ
GVD
EQ
GNAIDV
V
DP
M
--
L
A
E
F
Q
K
I
N
AQ
YQ
-----
GA
D
RV
K
ALL
G
L
SGI
F
A
DDLPQN
A
D
FV
G
AV
TA
A
Y
QQ
L
C
E
R
GARE
C
V
A
AL
fig|585397.9.peg.5177
Escherichia coli ED1a (13-486/486)
R
PSWDHSR
L
E
SRIVH
L
G
C
GAFHRAHQAL
Y
T
H
H
LLE
S
TD
S
DWGICEV
N
L
MP
G
N
D
RV
L
IEN
L
KK
Q
QL
LYTV
A
-----
EKGA
ES
TE
L
K
IIGS
M
K
E
--
A
L
H
P
E
I
D
GCEG
IL
NAMAR
PQ
T
AIVSLT
V
TEKGYC
A
D
A
A
S
G
Q
LD
L
N
NP
L
I
K
HDL
E
NP
TA
P
K
SA
I
G
Y
I
VEAL
RL
RRE
K
GLK
A
FTV
M
SCDN
V
RE
NGHV
A
K
V
AVLG
L
AQ
A
R
D
-
P
Q
-
LA
A
WI
E
E
N
V
T
FP
C
TMVDRIVPAAT
P
E
T
L
Q
EI
A
D
Q
LGV
Y
DPCAI
A
CEPF
R
QWVIE
-----------
DNFV
N
GRP
D
W
DKV
G
A
Q
F
V
A
DV
V
P
F
E
M
MKLRMLNGSHSFLAYLGYL
G
G
YE
TI
A
D
T
M
T
N
PAY
R
K
AA
FA
LM
M
Q
EQAPTL
S
M
P
E
G
T
DL
NA
YA
TL
LI
E
RF
S
NP
S
L
R
H
R
TWQIAMDGSQK
-----
LPQRLL
DP
V
R
L
HL
Q
NG
G
S
W
RH
LALGVAGWMRY
TQ
GVD
EQ
GNAIDV
V
DP
M
--
L
A
E
F
Q
K
I
N
AQ
YQ
-----
GA
D
RV
K
ALL
G
L
SGI
F
A
DDLPQN
A
D
FV
G
AV
TA
A
Y
QQ
L
C
E
R
GARE
C
V
A
AL
fig|316401.4.peg.5273
Escherichia coli ETEC H10407 (13-486/486)
R
PSWDHSR
L
E
SRIVH
L
G
C
GAFHRAHQAL
Y
T
H
H
LLE
S
TD
S
DWGICEV
N
L
MP
G
N
D
RV
L
IEN
L
KK
Q
QL
LYTV
A
-----
EKGA
ES
TE
L
K
IIGS
M
K
E
--
A
L
H
P
E
I
D
GCEG
IL
NAMAR
PQ
T
AIVSLT
V
TEKGYC
A
D
A
A
S
G
Q
LD
L
N
NP
L
I
K
HDL
E
NP
TA
P
K
SA
I
G
Y
I
VEAL
RL
RRE
K
GLK
A
FTV
M
SCDN
V
RE
NGHV
A
K
V
AVLG
L
AQ
A
R
D
-
P
Q
-
LA
A
WI
E
E
N
V
T
FP
C
TMVDRIVPAAT
P
E
T
L
Q
EI
A
D
Q
LGV
Y
DPCAI
A
CEPF
R
QWVIE
-----------
DNFV
N
GRP
D
W
DKV
G
A
Q
F
V
A
DV
V
P
F
E
M
MKLRMLNGSHSFLAYLGYL
G
G
YE
TI
A
D
T
M
T
N
PAY
R
K
AA
FA
LM
M
Q
EQAPTL
S
M
P
E
G
T
DL
NA
YA
TL
LI
E
RF
S
NP
S
L
R
H
R
TWQIAMDGSQK
-----
LPQRLL
DP
V
R
L
HL
Q
NG
G
S
W
RH
LALGVAGWMRY
TQ
GVD
EQ
GNAIDV
V
DP
M
--
L
A
E
F
Q
K
I
N
AQ
YQ
-----
GA
D
RV
K
ALL
G
L
SGI
F
A
DDLPQN
A
D
FV
G
AV
TA
A
Y
QQ
L
C
E
R
GARE
C
V
A
AL
fig|340197.3.peg.748
Escherichia coli F11 (13-486/486)
R
PSWDHSR
L
E
SRIVH
L
G
C
GAFHRAHQAL
Y
T
H
H
LLE
S
TD
S
DWGICEV
N
L
MP
G
N
D
RV
L
IEN
L
KK
Q
QL
LYTV
A
-----
EKGA
ES
TE
L
K
IIGS
M
K
E
--
A
L
H
P
E
I
D
GCEG
IL
NAMAR
PQ
T
AIVSLT
V
TEKGYC
A
D
A
A
S
G
Q
LD
L
N
NP
L
I
K
HDL
E
NP
TA
P
K
SA
I
G
Y
I
VEAL
RL
RRE
K
GLK
A
FTV
M
SCDN
V
RE
NGHV
A
K
V
AVLG
L
AQ
A
R
D
-
P
Q
-
LA
A
WI
E
E
N
V
T
FP
C
TMVDRIVPAAT
P
E
T
L
Q
EI
A
D
Q
LGV
Y
DPCAI
A
CEPF
R
QWVIE
-----------
DNFV
N
GRP
D
W
DKV
G
A
Q
F
V
A
DV
V
P
F
E
M
MKLRMLNGSHSFLAYLGYL
G
G
YE
TI
A
D
T
M
T
N
PAY
R
K
AA
FA
LM
M
Q
EQAPTL
S
M
P
E
G
T
DL
NA
YA
TL
LI
E
RF
S
NP
S
L
R
H
R
TWQIAMDGSQK
-----
LPQRLL
DP
V
R
L
HL
Q
NG
G
S
W
RH
LALGVAGWMRY
TQ
GVD
EQ
GNAIDV
V
DP
M
--
L
A
E
F
Q
K
I
N
AQ
YQ
-----
GA
D
RV
K
ALL
G
L
SGI
F
A
DDLPQN
A
D
FV
G
AV
TA
A
Y
QQ
L
C
E
R
GARE
C
V
A
AL
fig|340197.5.peg.775
Escherichia coli F11 (13-486/486)
R
PSWDHSR
L
E
SRIVH
L
G
C
GAFHRAHQAL
Y
T
H
H
LLE
S
TD
S
DWGICEV
N
L
MP
G
N
D
RV
L
IEN
L
KK
Q
QL
LYTV
A
-----
EKGA
ES
TE
L
K
IIGS
M
K
E
--
A
L
H
P
E
I
D
GCEG
IL
NAMAR
PQ
T
AIVSLT
V
TEKGYC
A
D
A
A
S
G
Q
LD
L
N
NP
L
I
K
HDL
E
NP
TA
P
K
SA
I
G
Y
I
VEAL
RL
RRE
K
GLK
A
FTV
M
SCDN
V
RE
NGHV
A
K
V
AVLG
L
AQ
A
R
D
-
P
Q
-
LA
A
WI
E
E
N
V
T
FP
C
TMVDRIVPAAT
P
E
T
L
Q
EI
A
D
Q
LGV
Y
DPCAI
A
CEPF
R
QWVIE
-----------
DNFV
N
GRP
D
W
DKV
G
A
Q
F
V
A
DV
V
P
F
E
M
MKLRMLNGSHSFLAYLGYL
G
G
YE
TI
A
D
T
M
T
N
PAY
R
K
AA
FA
LM
M
Q
EQAPTL
S
M
P
E
G
T
DL
NA
YA
TL
LI
E
RF
S
NP
S
L
R
H
R
TWQIAMDGSQK
-----
LPQRLL
DP
V
R
L
HL
Q
NG
G
S
W
RH
LALGVAGWMRY
TQ
GVD
EQ
GNAIDV
V
DP
M
--
L
A
E
F
Q
K
I
N
AQ
YQ
-----
GA
D
RV
K
ALL
G
L
SGI
F
A
DDLPQN
A
D
FV
G
AV
TA
A
Y
QQ
L
C
E
R
GARE
C
V
A
AL
fig|585034.4.peg.4408
Escherichia coli IAI1 (13-486/486)
R
PSWDHSR
L
E
SRIVH
L
G
C
GAFHRAHQAL
Y
T
H
H
LLE
S
TD
S
DWGICEV
N
L
MP
G
N
D
RV
L
IEN
L
KK
Q
QL
LYTV
A
-----
EKGA
ES
TE
L
K
IIGS
M
K
E
--
A
L
H
P
E
I
D
GCEG
IL
NAMAR
PQ
T
AIVSLT
V
TEKGYC
A
D
A
A
S
G
Q
LD
L
N
NP
L
I
K
HDL
E
NP
TA
P
K
SA
I
G
Y
I
VEAL
RL
RRE
K
GLK
A
FTV
M
SCDN
V
RE
NGHV
A
K
V
AVLG
L
AQ
A
R
D
-
P
Q
-
LA
A
WI
E
E
N
V
T
FP
C
TMVDRIVPAAT
P
E
T
L
Q
EI
A
D
Q
LGV
Y
DPCAI
A
CEPF
R
QWVIE
-----------
DNFV
N
GRP
D
W
DKV
G
A
Q
F
V
A
DV
V
P
F
E
M
MKLRMLNGSHSFLAYLGYL
G
G
YE
TI
A
D
T
M
T
N
PAY
R
K
AA
FA
LM
M
Q
EQAPTL
S
M
P
E
G
T
DL
NA
YA
TL
LI
E
RF
S
NP
S
L
R
H
R
TWQIAMDGSQK
-----
LPQRLL
DP
V
R
L
HL
Q
NG
G
S
W
RH
LALGVAGWMRY
TQ
GVD
EQ
GNAIDV
V
DP
M
--
L
A
E
F
Q
K
I
N
AQ
YQ
-----
GA
D
RV
K
ALL
G
L
SGI
F
A
DDLPQN
A
D
FV
G
AV
TA
A
Y
QQ
L
C
E
R
GARE
C
V
A
AL
fig|585034.5.peg.4403
Escherichia coli IAI1 (13-486/486)
R
PSWDHSR
L
E
SRIVH
L
G
C
GAFHRAHQAL
Y
T
H
H
LLE
S
TD
S
DWGICEV
N
L
MP
G
N
D
RV
L
IEN
L
KK
Q
QL
LYTV
A
-----
EKGA
ES
TE
L
K
IIGS
M
K
E
--
A
L
H
P
E
I
D
GCEG
IL
NAMAR
PQ
T
AIVSLT
V
TEKGYC
A
D
A
A
S
G
Q
LD
L
N
NP
L
I
K
HDL
E
NP
TA
P
K
SA
I
G
Y
I
VEAL
RL
RRE
K
GLK
A
FTV
M
SCDN
V
RE
NGHV
A
K
V
AVLG
L
AQ
A
R
D
-
P
Q
-
LA
A
WI
E
E
N
V
T
FP
C
TMVDRIVPAAT
P
E
T
L
Q
EI
A
D
Q
LGV
Y
DPCAI
A
CEPF
R
QWVIE
-----------
DNFV
N
GRP
D
W
DKV
G
A
Q
F
V
A
DV
V
P
F
E
M
MKLRMLNGSHSFLAYLGYL
G
G
YE
TI
A
D
T
M
T
N
PAY
R
K
AA
FA
LM
M
Q
EQAPTL
S
M
P
E
G
T
DL
NA
YA
TL
LI
E
RF
S
NP
S
L
R
H
R
TWQIAMDGSQK
-----
LPQRLL
DP
V
R
L
HL
Q
NG
G
S
W
RH
LALGVAGWMRY
TQ
GVD
EQ
GNAIDV
V
DP
M
--
L
A
E
F
Q
K
I
N
AQ
YQ
-----
GA
D
RV
K
ALL
G
L
SGI
F
A
DDLPQN
A
D
FV
G
AV
TA
A
Y
QQ
L
C
E
R
GARE
C
V
A
AL
fig|656417.3.peg.5523
Escherichia coli M605 (13-486/486)
R
PSWDHSR
L
E
SRIVH
L
G
C
GAFHRAHQAL
Y
T
H
H
LLE
S
TD
S
DWGICEV
N
L
MP
G
N
D
RV
L
IEN
L
KK
Q
QL
LYTV
A
-----
EKGA
ES
TE
L
K
IIGS
M
K
E
--
A
L
H
P
E
I
D
GCEG
IL
NAMAR
PQ
T
AIVSLT
V
TEKGYC
A
D
A
A
S
G
Q
LD
L
N
NP
L
I
K
HDL
E
NP
TA
P
K
SA
I
G
Y
I
VEAL
RL
RRE
K
GLK
A
FTV
M
SCDN
V
RE
NGHV
A
K
V
AVLG
L
AQ
A
R
D
-
P
Q
-
LA
A
WI
E
E
N
V
T
FP
C
TMVDRIVPAAT
P
E
T
L
Q
EI
A
D
Q
LGV
Y
DPCAI
A
CEPF
R
QWVIE
-----------
DNFV
N
GRP
D
W
DKV
G
A
Q
F
V
A
DV
V
P
F
E
M
MKLRMLNGSHSFLAYLGYL
G
G
YE
TI
A
D
T
M
T
N
PAY
R
K
AA
FA
LM
M
Q
EQAPTL
S
M
P
E
G
T
DL
NA
YA
TL
LI
E
RF
S
NP
S
L
R
H
R
TWQIAMDGSQK
-----
LPQRLL
DP
V
R
L
HL
Q
NG
G
S
W
RH
LALGVAGWMRY
TQ
GVD
EQ
GNAIDV
V
DP
M
--
L
A
E
F
Q
K
I
N
AQ
YQ
-----
GA
D
RV
K
ALL
G
L
SGI
F
A
DDLPQN
A
D
FV
G
AV
TA
A
Y
QQ
L
C
E
R
GARE
C
V
A
AL
fig|679205.4.peg.3593
Escherichia coli MS 124-1 (13-486/486)
R
PSWDHSR
L
E
SRIVH
L
G
C
GAFHRAHQAL
Y
T
H
H
LLE
S
TD
S
DWGICEV
N
L
MP
G
N
D
RV
L
IEN
L
KK
Q
QL
LYTV
A
-----
EKGA
ES
TE
L
K
IIGS
M
K
E
--
A
L
H
P
E
I
D
GCEG
IL
NAMAR
PQ
T
AIVSLT
V
TEKGYC
A
D
A
A
S
G
Q
LD
L
N
NP
L
I
K
HDL
E
NP
TA
P
K
SA
I
G
Y
I
VEAL
RL
RRE
K
GLK
A
FTV
M
SCDN
V
RE
NGHV
A
K
V
AVLG
L
AQ
A
R
D
-
P
Q
-
LA
A
WI
E
E
N
V
T
FP
C
TMVDRIVPAAT
P
E
T
L
Q
EI
A
D
Q
LGV
Y
DPCAI
A
CEPF
R
QWVIE
-----------
DNFV
N
GRP
D
W
DKV
G
A
Q
F
V
A
DV
V
P
F
E
M
MKLRMLNGSHSFLAYLGYL
G
G
YE
TI
A
D
T
M
T
N
PAY
R
K
AA
FA
LM
M
Q
EQAPTL
S
M
P
E
G
T
DL
NA
YA
TL
LI
E
RF
S
NP
S
L
R
H
R
TWQIAMDGSQK
-----
LPQRLL
DP
V
R
L
HL
Q
NG
G
S
W
RH
LALGVAGWMRY
TQ
GVD
EQ
GNAIDV
V
DP
M
--
L
A
E
F
Q
K
I
N
AQ
YQ
-----
GA
D
RV
K
ALL
G
L
SGI
F
A
DDLPQN
A
D
FV
G
AV
TA
A
Y
QQ
L
C
E
R
GARE
C
V
A
AL
fig|749547.3.peg.1088
Escherichia coli MS 187-1 (13-486/486)
R
PSWDHSR
L
E
SRIVH
L
G
C
GAFHRAHQAL
Y
T
H
H
LLE
S
TD
S
DWGICEV
N
L
MP
G
N
D
RV
L
IEN
L
KK
Q
QL
LYTV
A
-----
EKGA
ES
TE
L
K
IIGS
M
K
E
--
A
L
H
P
E
I
D
GCEG
IL
NAMAR
PQ
T
AIVSLT
V
TEKGYC
A
D
A
A
S
G
Q
LD
L
N
NP
L
I
K
HDL
E
NP
TA
P
K
SA
I
G
Y
I
VEAL
RL
RRE
K
GLK
A
FTV
M
SCDN
V
RE
NGHV
A
K
V
AVLG
L
AQ
A
R
D
-
P
Q
-
LA
A
WI
E
E
N
V
T
FP
C
TMVDRIVPAAT
P
E
T
L
Q
EI
A
D
Q
LGV
Y
DPCAI
A
CEPF
R
QWVIE
-----------
DNFV
N
GRP
D
W
DKV
G
A
Q
F
V
A
DV
V
P
F
E
M
MKLRMLNGSHSFLAYLGYL
G
G
YE
TI
A
D
T
M
T
N
PAY
R
K
AA
FA
LM
M
Q
EQAPTL
S
M
P
E
G
T
DL
NA
YA
TL
LI
E
RF
S
NP
S
L
R
H
R
TWQIAMDGSQK
-----
LPQRLL
DP
V
R
L
HL
Q
NG
G
S
W
RH
LALGVAGWMRY
TQ
GVD
EQ
GNAIDV
V
DP
M
--
L
A
E
F
Q
K
I
N
AQ
YQ
-----
GA
D
RV
K
ALL
G
L
SGI
F
A
DDLPQN
A
D
FV
G
AV
TA
A
Y
QQ
L
C
E
R
GARE
C
V
A
AL
fig|749550.3.peg.3887
Escherichia coli MS 200-1 (13-486/486)
R
PSWDHSR
L
E
SRIVH
L
G
C
GAFHRAHQAL
Y
T
H
H
LLE
S
TD
S
DWGICEV
N
L
MP
G
N
D
RV
L
IEN
L
KK
Q
QL
LYTV
A
-----
EKGA
ES
TE
L
K
IIGS
M
K
E
--
A
L
H
P
E
I
D
GCEG
IL
NAMAR
PQ
T
AIVSLT
V
TEKGYC
A
D
A
A
S
G
Q
LD
L
N
NP
L
I
K
HDL
E
NP
TA
P
K
SA
I
G
Y
I
VEAL
RL
RRE
K
GLK
A
FTV
M
SCDN
V
RE
NGHV
A
K
V
AVLG
L
AQ
A
R
D
-
P
Q
-
LA
A
WI
E
E
N
V
T
FP
C
TMVDRIVPAAT
P
E
T
L
Q
EI
A
D
Q
LGV
Y
DPCAI
A
CEPF
R
QWVIE
-----------
DNFV
N
GRP
D
W
DKV
G
A
Q
F
V
A
DV
V
P
F
E
M
MKLRMLNGSHSFLAYLGYL
G
G
YE
TI
A
D
T
M
T
N
PAY
R
K
AA
FA
LM
M
Q
EQAPTL
S
M
P
E
G
T
DL
NA
YA
TL
LI
E
RF
S
NP
S
L
R
H
R
TWQIAMDGSQK
-----
LPQRLL
DP
V
R
L
HL
Q
NG
G
S
W
RH
LALGVAGWMRY
TQ
GVD
EQ
GNAIDV
V
DP
M
--
L
A
E
F
Q
K
I
N
AQ
YQ
-----
GA
D
RV
K
ALL
G
L
SGI
F
A
DDLPQN
A
D
FV
G
AV
TA
A
Y
QQ
L
C
E
R
GARE
C
V
A
AL
fig|749533.3.peg.3184
Escherichia coli MS 84-1 (13-486/486)
R
PSWDHSR
L
E
SRIVH
L
G
C
GAFHRAHQAL
Y
T
H
H
LLE
S
TD
S
DWGICEV
N
L
MP
G
N
D
RV
L
IEN
L
KK
Q
QL
LYTV
A
-----
EKGA
ES
TE
L
K
IIGS
M
K
E
--
A
L
H
P
E
I
D
GCEG
IL
NAMAR
PQ
T
AIVSLT
V
TEKGYC
A
D
A
A
S
G
Q
LD
L
N
NP
L
I
K
HDL
E
NP
TA
P
K
SA
I
G
Y
I
VEAL
RL
RRE
K
GLK
A
FTV
M
SCDN
V
RE
NGHV
A
K
V
AVLG
L
AQ
A
R
D
-
P
Q
-
LA
A
WI
E
E
N
V
T
FP
C
TMVDRIVPAAT
P
E
T
L
Q
EI
A
D
Q
LGV
Y
DPCAI
A
CEPF
R
QWVIE
-----------
DNFV
N
GRP
D
W
DKV
G
A
Q
F
V
A
DV
V
P
F
E
M
MKLRMLNGSHSFLAYLGYL
G
G
YE
TI
A
D
T
M
T
N
PAY
R
K
AA
FA
LM
M
Q
EQAPTL
S
M
P
E
G
T
DL
NA
YA
TL
LI
E
RF
S
NP
S
L
R
H
R
TWQIAMDGSQK
-----
LPQRLL
DP
V
R
L
HL
Q
NG
G
S
W
RH
LALGVAGWMRY
TQ
GVD
EQ
GNAIDV
V
DP
M
--
L
A
E
F
Q
K
I
N
AQ
YQ
-----
GA
D
RV
K
ALL
G
L
SGI
F
A
DDLPQN
A
D
FV
G
AV
TA
A
Y
QQ
L
C
E
R
GARE
C
V
A
AL
fig|753642.3.peg.3747
Escherichia coli NC101 (13-486/486)
R
PSWDHSR
L
E
SRIVH
L
G
C
GAFHRAHQAL
Y
T
H
H
LLE
S
TD
S
DWGICEV
N
L
MP
G
N
D
RV
L
IEN
L
KK
Q
QL
LYTV
A
-----
EKGA
ES
TE
L
K
IIGS
M
K
E
--
A
L
H
P
E
I
D
GCEG
IL
NAMAR
PQ
T
AIVSLT
V
TEKGYC
A
D
A
A
S
G
Q
LD
L
N
NP
L
I
K
HDL
E
NP
TA
P
K
SA
I
G
Y
I
VEAL
RL
RRE
K
GLK
A
FTV
M
SCDN
V
RE
NGHV
A
K
V
AVLG
L
AQ
A
R
D
-
P
Q
-
LA
A
WI
E
E
N
V
T
FP
C
TMVDRIVPAAT
P
E
T
L
Q
EI
A
D
Q
LGV
Y
DPCAI
A
CEPF
R
QWVIE
-----------
DNFV
N
GRP
D
W
DKV
G
A
Q
F
V
A
DV
V
P
F
E
M
MKLRMLNGSHSFLAYLGYL
G
G
YE
TI
A
D
T
M
T
N
PAY
R
K
AA
FA
LM
M
Q
EQAPTL
S
M
P
E
G
T
DL
NA
YA
TL
LI
E
RF
S
NP
S
L
R
H
R
TWQIAMDGSQK
-----
LPQRLL
DP
V
R
L
HL
Q
NG
G
S
W
RH
LALGVAGWMRY
TQ
GVD
EQ
GNAIDV
V
DP
M
--
L
A
E
F
Q
K
I
N
AQ
YQ
-----
GA
D
RV
K
ALL
G
L
SGI
F
A
DDLPQN
A
D
FV
G
AV
TA
A
Y
QQ
L
C
E
R
GARE
C
V
A
AL
fig|574521.7.peg.4734
Escherichia coli O127:H6 str. E2348/69 (13-486/486)
R
PSWDHSR
L
E
SRIVH
L
G
C
GAFHRAHQAL
Y
T
H
H
LLE
S
TD
S
DWGICEV
N
L
MP
G
N
D
RV
L
IEN
L
KK
Q
QL
LYTV
A
-----
EKGA
ES
TE
L
K
IIGS
M
K
E
--
A
L
H
P
E
I
D
GCEG
IL
NAMAR
PQ
T
AIVSLT
V
TEKGYC
A
D
A
A
S
G
Q
LD
L
N
NP
L
I
K
HDL
E
NP
TA
P
K
SA
I
G
Y
I
VEAL
RL
RRE
K
GLK
A
FTV
M
SCDN
V
RE
NGHV
A
K
V
AVLG
L
AQ
A
R
D
-
P
Q
-
LA
A
WI
E
E
N
V
T
FP
C
TMVDRIVPAAT
P
E
T
L
Q
EI
A
D
Q
LGV
Y
DPCAI
A
CEPF
R
QWVIE
-----------
DNFV
N
GRP
D
W
DKV
G
A
Q
F
V
A
DV
V
P
F
E
M
MKLRMLNGSHSFLAYLGYL
G
G
YE
TI
A
D
T
M
T
N
PAY
R
K
AA
FA
LM
M
Q
EQAPTL
S
M
P
E
G
T
DL
NA
YA
TL
LI
E
RF
S
NP
S
L
R
H
R
TWQIAMDGSQK
-----
LPQRLL
DP
V
R
L
HL
Q
NG
G
S
W
RH
LALGVAGWMRY
TQ
GVD
EQ
GNAIDV
V
DP
M
--
L
A
E
F
Q
K
I
N
AQ
YQ
-----
GA
D
RV
K
ALL
G
L
SGI
F
A
DDLPQN
A
D
FV
G
AV
TA
A
Y
QQ
L
C
E
R
GARE
C
V
A
AL
fig|409438.11.peg.4781
Escherichia coli SE11 (13-486/486)
R
PSWDHSR
L
E
SRIVH
L
G
C
GAFHRAHQAL
Y
T
H
H
LLE
S
TD
S
DWGICEV
N
L
MP
G
N
D
RV
L
IEN
L
KK
Q
QL
LYTV
A
-----
EKGA
ES
TE
L
K
IIGS
M
K
E
--
A
L
H
P
E
I
D
GCEG
IL
NAMAR
PQ
T
AIVSLT
V
TEKGYC
A
D
A
A
S
G
Q
LD
L
N
NP
L
I
K
HDL
E
NP
TA
P
K
SA
I
G
Y
I
VEAL
RL
RRE
K
GLK
A
FTV
M
SCDN
V
RE
NGHV
A
K
V
AVLG
L
AQ
A
R
D
-
P
Q
-
LA
A
WI
E
E
N
V
T
FP
C
TMVDRIVPAAT
P
E
T
L
Q
EI
A
D
Q
LGV
Y
DPCAI
A
CEPF
R
QWVIE
-----------
DNFV
N
GRP
D
W
DKV
G
A
Q
F
V
A
DV
V
P
F
E
M
MKLRMLNGSHSFLAYLGYL
G
G
YE
TI
A
D
T
M
T
N
PAY
R
K
AA
FA
LM
M
Q
EQAPTL
S
M
P
E
G
T
DL
NA
YA
TL
LI
E
RF
S
NP
S
L
R
H
R
TWQIAMDGSQK
-----
LPQRLL
DP
V
R
L
HL
Q
NG
G
S
W
RH
LALGVAGWMRY
TQ
GVD
EQ
GNAIDV
V
DP
M
--
L
A
E
F
Q
K
I
N
AQ
YQ
-----
GA
D
RV
K
ALL
G
L
SGI
F
A
DDLPQN
A
D
FV
G
AV
TA
A
Y
QQ
L
C
E
R
GARE
C
V
A
AL
fig|431946.3.peg.4445
Escherichia coli SE15 (13-486/486)
R
PSWDHSR
L
E
SRIVH
L
G
C
GAFHRAHQAL
Y
T
H
H
LLE
S
TD
S
DWGICEV
N
L
MP
G
N
D
RV
L
IEN
L
KK
Q
QL
LYTV
A
-----
EKGA
ES
TE
L
K
IIGS
M
K
E
--
A
L
H
P
E
I
D
GCEG
IL
NAMAR
PQ
T
AIVSLT
V
TEKGYC
A
D
A
A
S
G
Q
LD
L
N
NP
L
I
K
HDL
E
NP
TA
P
K
SA
I
G
Y
I
VEAL
RL
RRE
K
GLK
A
FTV
M
SCDN
V
RE
NGHV
A
K
V
AVLG
L
AQ
A
R
D
-
P
Q
-
LA
A
WI
E
E
N
V
T
FP
C
TMVDRIVPAAT
P
E
T
L
Q
EI
A
D
Q
LGV
Y
DPCAI
A
CEPF
R
QWVIE
-----------
DNFV
N
GRP
D
W
DKV
G
A
Q
F
V
A
DV
V
P
F
E
M
MKLRMLNGSHSFLAYLGYL
G
G
YE
TI
A
D
T
M
T
N
PAY
R
K
AA
FA
LM
M
Q
EQAPTL
S
M
P
E
G
T
DL
NA
YA
TL
LI
E
RF
S
NP
S
L
R
H
R
TWQIAMDGSQK
-----
LPQRLL
DP
V
R
L
HL
Q
NG
G
S
W
RH
LALGVAGWMRY
TQ
GVD
EQ
GNAIDV
V
DP
M
--
L
A
E
F
Q
K
I
N
AQ
YQ
-----
GA
D
RV
K
ALL
G
L
SGI
F
A
DDLPQN
A
D
FV
G
AV
TA
A
Y
QQ
L
C
E
R
GARE
C
V
A
AL
fig|656440.3.peg.4947
Escherichia coli TA206 (13-486/486)
R
PSWDHSR
L
E
SRIVH
L
G
C
GAFHRAHQAL
Y
T
H
H
LLE
S
TD
S
DWGICEV
N
L
MP
G
N
D
RV
L
IEN
L
KK
Q
QL
LYTV
A
-----
EKGA
ES
TE
L
K
IIGS
M
K
E
--
A
L
H
P
E
I
D
GCEG
IL
NAMAR
PQ
T
AIVSLT
V
TEKGYC
A
D
A
A
S
G
Q
LD
L
N
NP
L
I
K
HDL
E
NP
TA
P
K
SA
I
G
Y
I
VEAL
RL
RRE
K
GLK
A
FTV
M
SCDN
V
RE
NGHV
A
K
V
AVLG
L
AQ
A
R
D
-
P
Q
-
LA
A
WI
E
E
N
V
T
FP
C
TMVDRIVPAAT
P
E
T
L
Q
EI
A
D
Q
LGV
Y
DPCAI
A
CEPF
R
QWVIE
-----------
DNFV
N
GRP
D
W
DKV
G
A
Q
F
V
A
DV
V
P
F
E
M
MKLRMLNGSHSFLAYLGYL
G
G
YE
TI
A
D
T
M
T
N
PAY
R
K
AA
FA
LM
M
Q
EQAPTL
S
M
P
E
G
T
DL
NA
YA
TL
LI
E
RF
S
NP
S
L
R
H
R
TWQIAMDGSQK
-----
LPQRLL
DP
V
R
L
HL
Q
NG
G
S
W
RH
LALGVAGWMRY
TQ
GVD
EQ
GNAIDV
V
DP
M
--
L
A
E
F
Q
K
I
N
AQ
YQ
-----
GA
D
RV
K
ALL
G
L
SGI
F
A
DDLPQN
A
D
FV
G
AV
TA
A
Y
QQ
L
C
E
R
GARE
C
V
A
AL
fig|656443.3.peg.19
Escherichia coli TA271 (13-486/486)
R
PSWDHSR
L
E
SRIVH
L
G
C
GAFHRAHQAL
Y
T
H
H
LLE
S
TD
S
DWGICEV
N
L
MP
G
N
D
RV
L
IEN
L
KK
Q
QL
LYTV
A
-----
EKGA
ES
TE
L
K
IIGS
M
K
E
--
A
L
H
P
E
I
D
GCEG
IL
NAMAR
PQ
T
AIVSLT
V
TEKGYC
A
D
A
A
S
G
Q
LD
L
N
NP
L
I
K
HDL
E
NP
TA
P
K
SA
I
G
Y
I
VEAL
RL
RRE
K
GLK
A
FTV
M
SCDN
V
RE
NGHV
A
K
V
AVLG
L
AQ
A
R
D
-
P
Q
-
LA
A
WI
E
E
N
V
T
FP
C
TMVDRIVPAAT
P
E
T
L
Q
EI
A
D
Q
LGV
Y
DPCAI
A
CEPF
R
QWVIE
-----------
DNFV
N
GRP
D
W
DKV
G
A
Q
F
V
A
DV
V
P
F
E
M
MKLRMLNGSHSFLAYLGYL
G
G
YE
TI
A
D
T
M
T
N
PAY
R
K
AA
FA
LM
M
Q
EQAPTL
S
M
P
E
G
T
DL
NA
YA
TL
LI
E
RF
S
NP
S
L
R
H
R
TWQIAMDGSQK
-----
LPQRLL
DP
V
R
L
HL
Q
NG
G
S
W
RH
LALGVAGWMRY
TQ
GVD
EQ
GNAIDV
V
DP
M
--
L
A
E
F
Q
K
I
N
AQ
YQ
-----
GA
D
RV
K
ALL
G
L
SGI
F
A
DDLPQN
A
D
FV
G
AV
TA
A
Y
QQ
L
C
E
R
GARE
C
V
A
AL
fig|562.376.peg.840
Escherichia coli WV_060327 (13-486/486)
R
PSWDHSR
L
E
SRIVH
L
G
C
GAFHRAHQAL
Y
T
H
H
LLE
S
TD
S
DWGICEV
N
L
MP
G
N
D
RV
L
IEN
L
KK
Q
QL
LYTV
A
-----
EKGA
ES
TE
L
K
IIGS
M
K
E
--
A
L
H
P
E
I
D
GCEG
IL
NAMAR
PQ
T
AIVSLT
V
TEKGYC
A
D
A
A
S
G
Q
LD
L
N
NP
L
I
K
HDL
E
NP
TA
P
K
SA
I
G
Y
I
VEAL
RL
RRE
K
GLK
A
FTV
M
SCDN
V
RE
NGHV
A
K
V
AVLG
L
AQ
A
R
D
-
P
Q
-
LA
A
WI
E
E
N
V
T
FP
C
TMVDRIVPAAT
P
E
T
L
Q
EI
A
D
Q
LGV
Y
DPCAI
A
CEPF
R
QWVIE
-----------
DNFV
N
GRP
D
W
DKV
G
A
Q
F
V
A
DV
V
P
F
E
M
MKLRMLNGSHSFLAYLGYL
G
G
YE
TI
A
D
T
M
T
N
PAY
R
K
AA
FA
LM
M
Q
EQAPTL
S
M
P
E
G
T
DL
NA
YA
TL
LI
E
RF
S
NP
S
L
R
H
R
TWQIAMDGSQK
-----
LPQRLL
DP
V
R
L
HL
Q
NG
G
S
W
RH
LALGVAGWMRY
TQ
GVD
EQ
GNAIDV
V
DP
M
--
L
A
E
F
Q
K
I
N
AQ
YQ
-----
GA
D
RV
K
ALL
G
L
SGI
F
A
DDLPQN
A
D
FV
G
AV
TA
A
Y
QQ
L
C
E
R
GARE
C
V
A
AL
fig|340186.3.peg.3339
Escherichia coli E110019 (13-486/486)
R
PSWDHSR
L
E
SRIVH
L
G
C
GAFHRAHQAL
Y
T
H
H
LLE
S
TD
S
DWGICEV
N
L
MP
G
N
D
RV
L
IEN
L
KK
Q
QL
LYTV
A
-----
EKGA
ES
TE
L
K
IIGS
M
K
E
--
A
L
H
P
E
I
D
GCEG
IL
NAMAR
PQ
T
AIVSLT
V
TEKGYC
A
D
A
A
S
G
Q
LD
L
N
NP
L
I
K
HDL
E
NP
TA
P
K
SA
I
G
Y
I
VEAL
RL
RRE
K
GLK
A
FTV
M
SCDN
V
RE
NGHV
A
K
V
AVLG
L
AQ
A
R
D
-
P
Q
-
LA
A
WI
G
E
N
V
T
FP
C
TMVDRIVPAAT
P
E
T
L
Q
EI
A
D
Q
LGV
Y
DPCAI
A
CEPF
R
QWVIE
-----------
DNFV
N
GRP
D
W
DKV
G
A
Q
F
V
A
DV
V
P
F
E
M
MKLRMLNGSHSFLAYLGYL
G
G
YE
TI
A
D
T
M
T
N
PDY
R
K
AA
FA
LM
M
Q
EQAPTL
S
M
P
E
G
T
DL
NA
YA
TL
LI
E
RF
S
NP
S
L
R
H
R
TWQIAMDGSQK
-----
LPQRLL
DP
V
R
L
HL
Q
NG
G
S
W
RH
LALGVAGWMRY
TQ
GVD
EQ
GNAIDV
V
DP
M
--
L
A
E
F
Q
K
I
N
AQ
YQ
-----
GA
D
RV
K
ALL
G
L
SGI
F
A
DDLPQN
A
D
FV
G
AV
TA
A
Y
QQ
L
C
E
R
GARE
C
V
A
AL
fig|340186.5.peg.3483
Escherichia coli E110019 (13-486/486)
R
PSWDHSR
L
E
SRIVH
L
G
C
GAFHRAHQAL
Y
T
H
H
LLE
S
TD
S
DWGICEV
N
L
MP
G
N
D
RV
L
IEN
L
KK
Q
QL
LYTV
A
-----
EKGA
ES
TE
L
K
IIGS
M
K
E
--
A
L
H
P
E
I
D
GCEG
IL
NAMAR
PQ
T
AIVSLT
V
TEKGYC
A
D
A
A
S
G
Q
LD
L
N
NP
L
I
K
HDL
E
NP
TA
P
K
SA
I
G
Y
I
VEAL
RL
RRE
K
GLK
A
FTV
M
SCDN
V
RE
NGHV
A
K
V
AVLG
L
AQ
A
R
D
-
P
Q
-
LA
A
WI
G
E
N
V
T
FP
C
TMVDRIVPAAT
P
E
T
L
Q
EI
A
D
Q
LGV
Y
DPCAI
A
CEPF
R
QWVIE
-----------
DNFV
N
GRP
D
W
DKV
G
A
Q
F
V
A
DV
V
P
F
E
M
MKLRMLNGSHSFLAYLGYL
G
G
YE
TI
A
D
T
M
T
N
PDY
R
K
AA
FA
LM
M
Q
EQAPTL
S
M
P
E
G
T
DL
NA
YA
TL
LI
E
RF
S
NP
S
L
R
H
R
TWQIAMDGSQK
-----
LPQRLL
DP
V
R
L
HL
Q
NG
G
S
W
RH
LALGVAGWMRY
TQ
GVD
EQ
GNAIDV
V
DP
M
--
L
A
E
F
Q
K
I
N
AQ
YQ
-----
GA
D
RV
K
ALL
G
L
SGI
F
A
DDLPQN
A
D
FV
G
AV
TA
A
Y
QQ
L
C
E
R
GARE
C
V
A
AL
fig|585035.6.peg.4842
Escherichia coli S88 (13-486/486)
R
PSWDHSR
L
E
SRIVH
L
G
C
GAFHRAHQAL
Y
T
H
H
LLE
S
TD
S
DWGICEV
N
L
MP
G
N
D
RV
L
IEN
L
KK
Q
QL
LYTV
A
-----
EKGA
ES
TE
L
K
IIGS
M
K
E
--
A
L
H
P
E
I
D
GCEG
IL
NAMAR
PQ
T
AIVSLT
V
TEKGYC
A
D
A
A
S
G
Q
LD
L
N
NP
L
I
K
HDL
E
NP
TA
P
K
SA
I
G
Y
I
VEAL
RL
RRE
K
GLK
A
FTV
M
SCDN
V
RE
NGHV
A
K
V
AVLG
L
AQ
A
R
D
-
P
Q
-
LA
A
WI
G
E
N
V
T
FP
C
TMVDRIVPAAT
P
E
T
L
Q
EI
A
D
Q
LGV
Y
DPCAI
A
CEPF
R
QWVIE
-----------
DNFV
N
GRP
D
W
DKV
G
A
Q
F
V
A
DV
V
P
F
E
M
MKLRMLNGSHSFLAYLGYL
G
G
YE
TI
A
D
T
M
T
N
PDY
R
K
AA
FA
LM
M
Q
EQAPTL
S
M
P
E
G
T
DL
NA
YA
TL
LI
E
RF
S
NP
S
L
R
H
R
TWQIAMDGSQK
-----
LPQRLL
DP
V
R
L
HL
Q
NG
G
S
W
RH
LALGVAGWMRY
TQ
GVD
EQ
GNAIDV
V
DP
M
--
L
A
E
F
Q
K
I
N
AQ
YQ
-----
GA
D
RV
K
ALL
G
L
SGI
F
A
DDLPQN
A
D
FV
G
AV
TA
A
Y
QQ
L
C
E
R
GARE
C
V
A
AL
fig|525281.3.peg.1354
Escherichia coli 83972 (13-486/486)
R
PSWDHSR
L
E
SRIVH
L
G
C
GAFHRAHQAL
Y
T
H
H
LLE
S
TD
S
DWGICEV
N
L
MP
G
N
D
RV
L
IEN
L
KK
Q
QL
LYTV
A
-----
EKGA
ES
TE
L
K
IIGS
M
K
E
--
A
L
H
P
E
I
D
GCEG
IL
NAMAR
PQ
T
AIVSLT
V
TEKGYC
A
D
A
A
S
G
Q
LD
L
N
NP
L
I
K
HDL
E
NP
TA
P
K
SA
I
G
Y
I
VEAL
RL
RRE
K
GLK
A
FTV
M
SCDN
V
RE
NGHV
A
K
V
AVLG
L
AQ
A
R
D
-
P
Q
-
LA
A
WI
E
E
N
V
T
FP
C
TMVDRIVPAAT
P
E
T
L
Q
EI
A
D
Q
LGV
Y
DPCAI
A
CEPF
R
QWVIE
-----------
DNFV
N
GRP
D
W
DKV
G
A
Q
F
V
A
DV
V
P
F
E
M
MKLRMLNGSHSFLAYLGYL
G
G
YE
TI
A
D
T
M
T
N
PAY
R
K
AA
FA
LM
M
Q
EQAPTL
S
M
P
E
G
T
DL
NA
YA
TL
LI
E
RF
S
NP
S
L
R
H
R
TWQIAMDGSQK
-----
LPQRLL
DP
V
R
L
HL
Q
NG
G
S
W
RH
LALGVAGWMRY
TQ
GVD
EQ
GNAIDV
V
DP
M
--
M
A
E
F
Q
K
I
N
AQ
YQ
-----
GA
D
RV
K
ALL
G
L
SGI
F
A
DDLPQN
A
D
FV
G
AV
TA
A
Y
QQ
L
C
E
R
GARE
C
V
A
AL
fig|655817.3.peg.5168
Escherichia coli ABU 83972 (13-486/486)
R
PSWDHSR
L
E
SRIVH
L
G
C
GAFHRAHQAL
Y
T
H
H
LLE
S
TD
S
DWGICEV
N
L
MP
G
N
D
RV
L
IEN
L
KK
Q
QL
LYTV
A
-----
EKGA
ES
TE
L
K
IIGS
M
K
E
--
A
L
H
P
E
I
D
GCEG
IL
NAMAR
PQ
T
AIVSLT
V
TEKGYC
A
D
A
A
S
G
Q
LD
L
N
NP
L
I
K
HDL
E
NP
TA
P
K
SA
I
G
Y
I
VEAL
RL
RRE
K
GLK
A
FTV
M
SCDN
V
RE
NGHV
A
K
V
AVLG
L
AQ
A
R
D
-
P
Q
-
LA
A
WI
E
E
N
V
T
FP
C
TMVDRIVPAAT
P
E
T
L
Q
EI
A
D
Q
LGV
Y
DPCAI
A
CEPF
R
QWVIE
-----------
DNFV
N
GRP
D
W
DKV
G
A
Q
F
V
A
DV
V
P
F
E
M
MKLRMLNGSHSFLAYLGYL
G
G
YE
TI
A
D
T
M
T
N
PAY
R
K
AA
FA
LM
M
Q
EQAPTL
S
M
P
E
G
T
DL
NA
YA
TL
LI
E
RF
S
NP
S
L
R
H
R
TWQIAMDGSQK
-----
LPQRLL
DP
V
R
L
HL
Q
NG
G
S
W
RH
LALGVAGWMRY
TQ
GVD
EQ
GNAIDV
V
DP
M
--
M
A
E
F
Q
K
I
N
AQ
YQ
-----
GA
D
RV
K
ALL
G
L
SGI
F
A
DDLPQN
A
D
FV
G
AV
TA
A
Y
QQ
L
C
E
R
GARE
C
V
A
AL
fig|199310.1.peg.5294
Escherichia coli CFT073 (13-486/486)
R
PSWDHSR
L
E
SRIVH
L
G
C
GAFHRAHQAL
Y
T
H
H
LLE
S
TD
S
DWGICEV
N
L
MP
G
N
D
RV
L
IEN
L
KK
Q
QL
LYTV
A
-----
EKGA
ES
TE
L
K
IIGS
M
K
E
--
A
L
H
P
E
I
D
GCEG
IL
NAMAR
PQ
T
AIVSLT
V
TEKGYC
A
D
A
A
S
G
Q
LD
L
N
NP
L
I
K
HDL
E
NP
TA
P
K
SA
I
G
Y
I
VEAL
RL
RRE
K
GLK
A
FTV
M
SCDN
V
RE
NGHV
A
K
V
AVLG
L
AQ
A
R
D
-
P
Q
-
LA
A
WI
E
E
N
V
T
FP
C
TMVDRIVPAAT
P
E
T
L
Q
EI
A
D
Q
LGV
Y
DPCAI
A
CEPF
R
QWVIE
-----------
DNFV
N
GRP
D
W
DKV
G
A
Q
F
V
A
DV
V
P
F
E
M
MKLRMLNGSHSFLAYLGYL
G
G
YE
TI
A
D
T
M
T
N
PAY
R
K
AA
FA
LM
M
Q
EQAPTL
S
M
P
E
G
T
DL
NA
YA
TL
LI
E
RF
S
NP
S
L
R
H
R
TWQIAMDGSQK
-----
LPQRLL
DP
V
R
L
HL
Q
NG
G
S
W
RH
LALGVAGWMRY
TQ
GVD
EQ
GNAIDV
V
DP
M
--
M
A
E
F
Q
K
I
N
AQ
YQ
-----
GA
D
RV
K
ALL
G
L
SGI
F
A
DDLPQN
A
D
FV
G
AV
TA
A
Y
QQ
L
C
E
R
GARE
C
V
A
AL
fig|199310.4.peg.5060
Escherichia coli CFT073 (13-486/486)
R
PSWDHSR
L
E
SRIVH
L
G
C
GAFHRAHQAL
Y
T
H
H
LLE
S
TD
S
DWGICEV
N
L
MP
G
N
D
RV
L
IEN
L
KK
Q
QL
LYTV
A
-----
EKGA
ES
TE
L
K
IIGS
M
K
E
--
A
L
H
P
E
I
D
GCEG
IL
NAMAR
PQ
T
AIVSLT
V
TEKGYC
A
D
A
A
S
G
Q
LD
L
N
NP
L
I
K
HDL
E
NP
TA
P
K
SA
I
G
Y
I
VEAL
RL
RRE
K
GLK
A
FTV
M
SCDN
V
RE
NGHV
A
K
V
AVLG
L
AQ
A
R
D
-
P
Q
-
LA
A
WI
E
E
N
V
T
FP
C
TMVDRIVPAAT
P
E
T
L
Q
EI
A
D
Q
LGV
Y
DPCAI
A
CEPF
R
QWVIE
-----------
DNFV
N
GRP
D
W
DKV
G
A
Q
F
V
A
DV
V
P
F
E
M
MKLRMLNGSHSFLAYLGYL
G
G
YE
TI
A
D
T
M
T
N
PAY
R
K
AA
FA
LM
M
Q
EQAPTL
S
M
P
E
G
T
DL
NA
YA
TL
LI
E
RF
S
NP
S
L
R
H
R
TWQIAMDGSQK
-----
LPQRLL
DP
V
R
L
HL
Q
NG
G
S
W
RH
LALGVAGWMRY
TQ
GVD
EQ
GNAIDV
V
DP
M
--
M
A
E
F
Q
K
I
N
AQ
YQ
-----
GA
D
RV
K
ALL
G
L
SGI
F
A
DDLPQN
A
D
FV
G
AV
TA
A
Y
QQ
L
C
E
R
GARE
C
V
A
AL
fig|749546.3.peg.2211
Escherichia coli MS 185-1 (13-486/486)
R
PSWDHSR
L
E
SRIVH
L
G
C
GAFHRAHQAL
Y
T
H
H
LLE
S
TD
S
DWGICEV
N
L
MP
G
N
D
RV
L
IEN
L
KK
Q
QL
LYTV
A
-----
EKGA
ES
TE
L
K
IIGS
M
K
E
--
A
L
H
P
E
I
D
GCEG
IL
NAMAR
PQ
T
AIVSLT
V
TEKGYC
A
D
A
A
S
G
Q
LD
L
N
NP
L
I
K
HDL
E
NP
TA
P
K
SA
I
G
Y
I
VEAL
RL
RRE
K
GLK
A
FTV
M
SCDN
V
RE
NGHV
A
K
V
AVLG
L
AQ
A
R
D
-
P
Q
-
LA
A
WI
E
E
N
V
T
FP
C
TMVDRIVPAAT
P
E
T
L
Q
EI
A
D
Q
LGV
Y
DPCAI
A
CEPF
R
QWVIE
-----------
DNFV
N
GRP
D
W
DKV
G
A
Q
F
V
A
DV
V
P
F
E
M
MKLRMLNGSHSFLAYLGYL
G
G
YE
TI
A
D
T
M
T
N
PAY
R
K
AA
FA
LM
M
Q
EQAPTL
S
M
P
E
G
T
DL
NA
YA
TL
LI
E
RF
S
NP
S
L
R
H
R
TWQIAMDGSQK
-----
LPQRLL
DP
V
R
L
HL
Q
NG
G
S
W
RH
LALGVAGWMRY
TQ
GVD
EQ
GNAIDV
V
DP
M
--
M
A
E
F
Q
K
I
N
AQ
YQ
-----
GA
D
RV
K
ALL
G
L
SGI
F
A
DDLPQN
A
D
FV
G
AV
TA
A
Y
QQ
L
C
E
R
GARE
C
V
A
AL
fig|749528.3.peg.2055
Escherichia coli MS 45-1 (13-486/486)
R
PSWDHSR
L
E
SRIVH
L
G
C
GAFHRAHQAL
Y
T
H
H
LLE
S
TD
S
DWGICEV
N
L
MP
G
N
D
RV
L
IEN
L
KK
Q
QL
LYTV
A
-----
EKGA
ES
TE
L
K
IIGS
M
K
E
--
A
L
H
P
E
I
D
GCEG
IL
NAMAR
PQ
T
AIVSLT
V
TEKGYC
A
D
A
A
S
G
Q
LD
L
N
NP
L
I
K
HDL
E
NP
TA
P
K
SA
I
G
Y
I
VEAL
RL
RRE
K
GLK
A
FTV
M
SCDN
V
RE
NGHV
A
K
V
AVLG
L
AQ
A
R
D
-
P
Q
-
LA
A
WI
E
E
N
V
T
FP
C
TMVDRIVPAAT
P
E
T
L
Q
EI
A
D
Q
LGV
Y
DPCAI
A
CEPF
R
QWVIE
-----------
DNFV
N
GRP
D
W
DKV
G
A
Q
F
V
A
DV
V
P
F
E
M
MKLRMLNGSHSFLAYLGYL
G
G
YE
TI
A
D
T
M
T
N
PAY
R
K
AA
FA
LM
M
Q
EQAPTL
S
M
P
E
G
T
DL
NA
YA
TL
LI
E
RF
S
NP
S
L
R
H
R
TWQIAMDGSQK
-----
LPQRLL
DP
V
R
L
HL
Q
NG
G
S
W
RH
LALGVAGWMRY
TQ
GVD
EQ
GNAIDV
V
DP
M
--
M
A
E
F
Q
K
I
N
AQ
YQ
-----
GA
D
RV
K
ALL
G
L
SGI
F
A
DDLPQN
A
D
FV
G
AV
TA
A
Y
QQ
L
C
E
R
GARE
C
V
A
AL
fig|749531.3.peg.2141
Escherichia coli MS 69-1 (13-486/486)
R
PSWDHSR
L
E
SRIVH
L
G
C
GAFHRAHQAL
Y
T
H
H
LLE
S
TD
S
DWGICEV
N
L
MP
G
N
D
RV
L
IEN
L
KK
Q
QL
LYTV
A
-----
EKGA
ES
TE
L
K
IIGS
M
K
E
--
A
L
H
P
E
I
D
GCEG
IL
NAMAR
PQ
T
AIVSLT
V
TEKGYC
A
D
A
A
S
G
Q
LD
L
N
NP
L
I
K
HDL
E
NP
TA
P
K
SA
I
G
Y
I
VEAL
RL
RRE
K
GLK
A
FTV
M
SCDN
V
RE
NGHV
A
K
V
AVLG
L
AQ
A
R
D
-
P
Q
-
LA
A
WI
E
E
N
V
T
FP
C
TMVDRIVPAAT
P
E
T
L
Q
EI
A
D
Q
LGV
Y
DPCAI
A
CEPF
R
QWVIE
-----------
DNFV
N
GRP
D
W
DKV
G
A
Q
F
V
A
DV
V
P
F
E
M
MKLRMLNGSHSFLAYLGYL
G
G
YE
TI
A
D
T
M
T
N
PDY
R
K
AA
FA
LM
M
Q
EQAPTL
S
M
P
E
G
T
DL
NA
YA
TL
LI
E
RF
S
NP
S
L
R
H
R
TWQIAMDGSQK
-----
LPQRLL
DP
V
R
L
HL
Q
NG
G
S
W
RH
LALGVAGWMRY
TQ
GVD
EQ
GNAIDV
V
DP
M
--
L
A
E
F
H
K
I
N
AQ
YQ
-----
GA
D
RV
K
ALL
G
L
SGI
F
A
DDLPQN
A
D
FV
G
AV
TA
A
Y
QQ
L
C
E
R
GARE
C
V
A
AL
fig|413997.3.peg.4427
Escherichia coli B str. REL606 (13-486/486)
R
PSWDHSR
L
E
SRIVH
L
G
C
GAFHRAHQAL
Y
T
H
H
LLE
S
TD
S
DWGICEV
N
L
MP
G
N
D
RV
L
IEN
L
KK
Q
QL
LYTV
A
-----
EKGA
ES
TE
L
K
IIGS
M
K
E
--
A
L
H
P
E
I
D
GCEG
IL
NAMAR
PQ
T
AIVSLT
V
TEKGYC
A
D
A
A
S
G
Q
LD
L
N
NP
L
I
K
HDL
E
NP
TA
P
K
SA
I
G
Y
I
VEAL
RL
RRE
K
GLK
A
FTV
M
SCDN
V
RE
NGHV
A
K
V
AVLG
L
AQ
A
R
D
-
P
Q
-
LA
A
WI
E
E
N
V
T
FP
C
TMVDRIVPAAT
P
E
T
I
Q
EI
A
D
Q
LGV
Y
DPCAI
A
CEPF
R
QWVIE
-----------
DNFV
N
GRP
D
W
DKV
G
A
Q
F
V
A
DV
V
P
F
E
M
MKLRMLNGSHSFLAYLGYL
G
G
YE
TI
A
D
T
V
T
N
PAY
R
K
AA
FA
LM
M
Q
EQAPTL
S
M
P
E
G
T
DL
NA
YA
TL
LI
E
RF
S
NP
S
L
R
H
R
TWQIAMDGSQK
-----
LPQRLL
DP
V
R
L
HL
Q
NG
G
S
W
RH
LALGVAGWMRY
TQ
GVD
EQ
GNAIDV
V
DP
M
--
L
A
E
F
Q
K
I
N
AQ
YQ
-----
GA
D
RV
K
ALL
G
L
SGI
F
A
DDLPQN
A
D
FV
G
AV
TA
A
Y
QQ
L
C
E
R
GARE
C
V
A
AL
fig|511693.5.peg.4450
Escherichia coli BL21 (13-486/486)
R
PSWDHSR
L
E
SRIVH
L
G
C
GAFHRAHQAL
Y
T
H
H
LLE
S
TD
S
DWGICEV
N
L
MP
G
N
D
RV
L
IEN
L
KK
Q
QL
LYTV
A
-----
EKGA
ES
TE
L
K
IIGS
M
K
E
--
A
L
H
P
E
I
D
GCEG
IL
NAMAR
PQ
T
AIVSLT
V
TEKGYC
A
D
A
A
S
G
Q
LD
L
N
NP
L
I
K
HDL
E
NP
TA
P
K
SA
I
G
Y
I
VEAL
RL
RRE
K
GLK
A
FTV
M
SCDN
V
RE
NGHV
A
K
V
AVLG
L
AQ
A
R
D
-
P
Q
-
LA
A
WI
E
E
N
V
T
FP
C
TMVDRIVPAAT
P
E
T
I
Q
EI
A
D
Q
LGV
Y
DPCAI
A
CEPF
R
QWVIE
-----------
DNFV
N
GRP
D
W
DKV
G
A
Q
F
V
A
DV
V
P
F
E
M
MKLRMLNGSHSFLAYLGYL
G
G
YE
TI
A
D
T
V
T
N
PAY
R
K
AA
FA
LM
M
Q
EQAPTL
S
M
P
E
G
T
DL
NA
YA
TL
LI
E
RF
S
NP
S
L
R
H
R
TWQIAMDGSQK
-----
LPQRLL
DP
V
R
L
HL
Q
NG
G
S
W
RH
LALGVAGWMRY
TQ
GVD
EQ
GNAIDV
V
DP
M
--
L
A
E
F
Q
K
I
N
AQ
YQ
-----
GA
D
RV
K
ALL
G
L
SGI
F
A
DDLPQN
A
D
FV
G
AV
TA
A
Y
QQ
L
C
E
R
GARE
C
V
A
AL
fig|469008.4.peg.3843
Escherichia coli BL21(DE3) (13-486/486)
R
PSWDHSR
L
E
SRIVH
L
G
C
GAFHRAHQAL
Y
T
H
H
LLE
S
TD
S
DWGICEV
N
L
MP
G
N
D
RV
L
IEN
L
KK
Q
QL
LYTV
A
-----
EKGA
ES
TE
L
K
IIGS
M
K
E
--
A
L
H
P
E
I
D
GCEG
IL
NAMAR
PQ
T
AIVSLT
V
TEKGYC
A
D
A
A
S
G
Q
LD
L
N
NP
L
I
K
HDL
E
NP
TA
P
K
SA
I
G
Y
I
VEAL
RL
RRE
K
GLK
A
FTV
M
SCDN
V
RE
NGHV
A
K
V
AVLG
L
AQ
A
R
D
-
P
Q
-
LA
A
WI
E
E
N
V
T
FP
C
TMVDRIVPAAT
P
E
T
I
Q
EI
A
D
Q
LGV
Y
DPCAI
A
CEPF
R
QWVIE
-----------
DNFV
N
GRP
D
W
DKV
G
A
Q
F
V
A
DV
V
P
F
E
M
MKLRMLNGSHSFLAYLGYL
G
G
YE
TI
A
D
T
V
T
N
PAY
R
K
AA
FA
LM
M
Q
EQAPTL
S
M
P
E
G
T
DL
NA
YA
TL
LI
E
RF
S
NP
S
L
R
H
R
TWQIAMDGSQK
-----
LPQRLL
DP
V
R
L
HL
Q
NG
G
S
W
RH
LALGVAGWMRY
TQ
GVD
EQ
GNAIDV
V
DP
M
--
L
A
E
F
Q
K
I
N
AQ
YQ
-----
GA
D
RV
K
ALL
G
L
SGI
F
A
DDLPQN
A
D
FV
G
AV
TA
A
Y
QQ
L
C
E
R
GARE
C
V
A
AL
fig|749548.3.peg.569
Escherichia coli MS 196-1 (13-486/486)
R
PSWDHSR
L
E
SRIVH
L
G
C
GAFHRAHQAL
Y
T
H
H
LLE
S
TD
S
DWGICEV
N
L
MP
G
N
D
RV
L
IEN
L
KK
Q
QL
LYTV
A
-----
EKGA
ES
TE
L
K
IIGS
M
K
E
--
A
L
H
P
E
I
D
GCEG
IL
NAMAR
PQ
T
AIVSLT
V
TEKGYC
A
D
A
A
S
G
Q
LD
L
N
NP
L
I
K
HDL
E
T
P
TA
P
K
SA
I
G
Y
I
VEAL
RL
RRE
K
GLK
A
FTV
M
SCDN
V
RE
NGHV
A
K
V
AVLG
L
AQ
A
R
D
-
P
Q
-
LA
A
WI
E
E
N
V
T
FP
C
TMVDRIVPAAT
P
E
T
I
Q
EI
A
D
Q
LGV
Y
DPCAI
A
CEPF
R
QWVIE
-----------
DNFV
N
GRP
D
W
DKV
G
A
Q
F
V
A
DV
V
P
F
E
M
MKLRMLNGSHSFLAYLGYL
G
G
YE
TI
A
D
T
V
T
N
PAY
R
K
AA
FA
LM
M
Q
EQAPTL
S
M
P
E
G
T
DL
NA
YA
TL
LI
E
RF
S
NP
S
L
R
H
R
TWQIAMDGSQK
-----
LPQRLL
DP
V
R
L
HL
Q
NG
G
S
W
RH
LALGVAGWMRY
TQ
GVD
EQ
GNAIDV
V
DP
M
--
L
A
E
F
Q
K
I
N
AQ
YQ
-----
GA
D
RV
K
ALL
G
L
SGI
F
A
DDLPQN
A
D
FV
G
AV
TA
A
Y
QQ
L
C
E
R
GARE
C
V
A
AL
fig|637912.3.peg.1846
Escherichia coli OP50 (13-486/486)
R
PSWDHSR
L
E
SRIVH
L
G
C
GAFHRAHQAL
Y
T
H
H
LLE
S
TD
S
DWGICEV
N
L
MP
G
N
D
RV
L
IEN
L
KK
Q
QL
LYTV
A
-----
EKGA
ES
TE
L
K
IIGS
M
K
E
--
A
L
H
P
E
I
D
GCEG
IL
NAMAR
PQ
T
AIVSLT
V
TEKGYC
A
D
A
A
S
G
Q
LD
L
N
NP
L
I
K
HDL
E
NP
TA
P
K
SA
I
G
Y
I
VEAL
RL
RRE
K
GLK
A
FTV
M
SCDN
V
RE
NGHV
A
K
V
AVLG
L
AQ
A
R
D
-
P
Q
-
LA
A
WI
E
E
N
V
T
FP
C
TMVDRIVPAAT
P
E
T
I
Q
EI
A
D
Q
LGV
Y
DPCAI
A
CEPF
R
QWVIE
-----------
DNFV
N
GRP
D
W
DKV
G
A
Q
F
V
A
DV
V
P
F
E
M
MKLRMLNGSHSFLAYLGYL
G
G
YE
TI
A
D
T
V
T
N
PAY
R
K
AA
FA
LM
M
Q
EQAPTL
S
M
P
E
G
T
DL
NA
YA
TL
LI
E
RF
S
NP
S
L
R
H
R
TWQIAMDGSQK
-----
LPQRLL
DP
V
R
L
HL
Q
NG
G
S
W
RH
LALGVAGWMRY
TQ
GVD
EQ
GNAIDV
V
DP
M
--
L
A
E
F
Q
K
I
N
AQ
YQ
-----
GA
D
RV
K
ALL
G
L
SGI
F
A
DDLPQN
A
D
FV
G
AV
TA
A
Y
QQ
L
C
E
R
GARE
C
V
A
AL
fig|595496.3.peg.4409
Escherichia coli BW2952 (13-486/486)
R
PSWDHSR
L
E
SRIVH
L
G
C
GAFHRAHQAL
Y
T
H
H
LLE
S
TD
S
DWGICEV
N
L
MP
G
N
D
RV
L
IEN
L
KK
Q
QL
LYTV
A
-----
EKGA
ES
TE
L
K
IIGS
M
K
E
--
A
L
H
P
E
I
D
GCEG
IL
NAMAR
PQ
T
AIVSLT
V
TEKGYC
A
D
A
A
S
G
Q
LD
L
N
NP
L
I
K
HDL
E
NP
TA
P
K
SA
I
G
Y
I
VEAL
RL
RRE
K
GLK
A
FTV
M
SCDN
V
RE
NGHV
A
K
V
AVLG
L
AQ
A
R
D
-
P
Q
-
LA
A
WI
E
E
N
V
T
FP
C
TMVDRIVPAAT
P
E
T
L
Q
EI
A
D
Q
LGV
Y
DPCAI
A
CEPF
R
QWVIE
-----------
DNFV
N
GRP
D
W
DKV
G
A
Q
F
V
A
DV
V
P
F
E
M
MKLRMLNGSHSFLAYLGYL
G
G
YE
TI
A
D
T
V
T
N
PAY
R
K
AA
FA
LM
M
Q
EQAPTL
S
M
P
E
G
T
DL
NA
YA
TL
LI
E
RF
S
NP
S
L
R
H
R
TWQIAMDGSQK
-----
LPQRLL
DP
V
R
L
HL
Q
NG
G
S
W
RH
LALGVAGWMRY
TQ
GVD
EQ
GNAIDV
V
DP
M
--
L
A
E
F
Q
K
I
N
AQ
YQ
-----
GA
D
RV
K
ALL
G
L
SGI
F
A
DDLPQN
A
D
FV
G
AV
TA
A
Y
QQ
L
C
E
R
GARE
C
V
A
AL
fig|536056.3.peg.3892
Escherichia coli DH1 (13-486/486)
R
PSWDHSR
L
E
SRIVH
L
G
C
GAFHRAHQAL
Y
T
H
H
LLE
S
TD
S
DWGICEV
N
L
MP
G
N
D
RV
L
IEN
L
KK
Q
QL
LYTV
A
-----
EKGA
ES
TE
L
K
IIGS
M
K
E
--
A
L
H
P
E
I
D
GCEG
IL
NAMAR
PQ
T
AIVSLT
V
TEKGYC
A
D
A
A
S
G
Q
LD
L
N
NP
L
I
K
HDL
E
NP
TA
P
K
SA
I
G
Y
I
VEAL
RL
RRE
K
GLK
A
FTV
M
SCDN
V
RE
NGHV
A
K
V
AVLG
L
AQ
A
R
D
-
P
Q
-
LA
A
WI
E
E
N
V
T
FP
C
TMVDRIVPAAT
P
E
T
L
Q
EI
A
D
Q
LGV
Y
DPCAI
A
CEPF
R
QWVIE
-----------
DNFV
N
GRP
D
W
DKV
G
A
Q
F
V
A
DV
V
P
F
E
M
MKLRMLNGSHSFLAYLGYL
G
G
YE
TI
A
D
T
V
T
N
PAY
R
K
AA
FA
LM
M
Q
EQAPTL
S
M
P
E
G
T
DL
NA
YA
TL
LI
E
RF
S
NP
S
L
R
H
R
TWQIAMDGSQK
-----
LPQRLL
DP
V
R
L
HL
Q
NG
G
S
W
RH
LALGVAGWMRY
TQ
GVD
EQ
GNAIDV
V
DP
M
--
L
A
E
F
Q
K
I
N
AQ
YQ
-----
GA
D
RV
K
ALL
G
L
SGI
F
A
DDLPQN
A
D
FV
G
AV
TA
A
Y
QQ
L
C
E
R
GARE
C
V
A
AL
fig|656379.3.peg.126
Escherichia coli FVEC1302 (13-486/486)
R
PSWDHSR
L
E
SRIVH
L
G
C
GAFHRAHQAL
Y
T
H
H
LLE
S
TD
S
DWGICEV
N
L
MP
G
N
D
RV
L
IEN
L
KK
Q
QL
LYTV
A
-----
EKGA
ES
TE
L
K
IIGS
M
K
E
--
A
L
H
P
E
I
D
GCEG
IL
NAMAR
PQ
T
AIVSLT
V
TEKGYC
A
D
A
A
S
G
Q
LD
L
N
NP
L
I
K
HDL
E
NP
TA
P
K
SA
I
G
Y
I
VEAL
RL
RRE
K
GLK
A
FTV
M
SCDN
V
RE
NGHV
A
K
V
AVLG
L
AQ
A
R
D
-
P
Q
-
LA
A
WI
E
E
N
V
T
FP
C
TMVDRIVPAAT
P
E
T
L
Q
EI
A
D
Q
LGV
Y
DPCAI
A
CEPF
R
QWVIE
-----------
DNFV
N
GRP
D
W
DKV
G
A
Q
F
V
A
DV
V
P
F
E
M
MKLRMLNGSHSFLAYLGYL
G
G
YE
TI
A
D
T
V
T
N
PAY
R
K
AA
FA
LM
M
Q
EQAPTL
S
M
P
E
G
T
DL
NA
YA
TL
LI
E
RF
S
NP
S
L
R
H
R
TWQIAMDGSQK
-----
LPQRLL
DP
V
R
L
HL
Q
NG
G
S
W
RH
LALGVAGWMRY
TQ
GVD
EQ
GNAIDV
V
DP
M
--
L
A
E
F
Q
K
I
N
AQ
YQ
-----
GA
D
RV
K
ALL
G
L
SGI
F
A
DDLPQN
A
D
FV
G
AV
TA
A
Y
QQ
L
C
E
R
GARE
C
V
A
AL
fig|656380.3.peg.67
Escherichia coli FVEC1412 (13-486/486)
R
PSWDHSR
L
E
SRIVH
L
G
C
GAFHRAHQAL
Y
T
H
H
LLE
S
TD
S
DWGICEV
N
L
MP
G
N
D
RV
L
IEN
L
KK
Q
QL
LYTV
A
-----
EKGA
ES
TE
L
K
IIGS
M
K
E
--
A
L
H
P
E
I
D
GCEG
IL
NAMAR
PQ
T
AIVSLT
V
TEKGYC
A
D
A
A
S
G
Q
LD
L
N
NP
L
I
K
HDL
E
NP
TA
P
K
SA
I
G
Y
I
VEAL
RL
RRE
K
GLK
A
FTV
M
SCDN
V
RE
NGHV
A
K
V
AVLG
L
AQ
A
R
D
-
P
Q
-
LA
A
WI
E
E
N
V
T
FP
C
TMVDRIVPAAT
P
E
T
L
Q
EI
A
D
Q
LGV
Y
DPCAI
A
CEPF
R
QWVIE
-----------
DNFV
N
GRP
D
W
DKV
G
A
Q
F
V
A
DV
V
P
F
E
M
MKLRMLNGSHSFLAYLGYL
G
G
YE
TI
A
D
T
V
T
N
PAY
R
K
AA
FA
LM
M
Q
EQAPTL
S
M
P
E
G
T
DL
NA
YA
TL
LI
E
RF
S
NP
S
L
R
H
R
TWQIAMDGSQK
-----
LPQRLL
DP
V
R
L
HL
Q
NG
G
S
W
RH
LALGVAGWMRY
TQ
GVD
EQ
GNAIDV
V
DP
M
--
L
A
E
F
Q
K
I
N
AQ
YQ
-----
GA
D
RV
K
ALL
G
L
SGI
F
A
DDLPQN
A
D
FV
G
AV
TA
A
Y
QQ
L
C
E
R
GARE
C
V
A
AL
fig|83333.1.peg.4233
Escherichia coli K12 (13-486/486)
R
PSWDHSR
L
E
SRIVH
L
G
C
GAFHRAHQAL
Y
T
H
H
LLE
S
TD
S
DWGICEV
N
L
MP
G
N
D
RV
L
IEN
L
KK
Q
QL
LYTV
A
-----
EKGA
ES
TE
L
K
IIGS
M
K
E
--
A
L
H
P
E
I
D
GCEG
IL
NAMAR
PQ
T
AIVSLT
V
TEKGYC
A
D
A
A
S
G
Q
LD
L
N
NP
L
I
K
HDL
E
NP
TA
P
K
SA
I
G
Y
I
VEAL
RL
RRE
K
GLK
A
FTV
M
SCDN
V
RE
NGHV
A
K
V
AVLG
L
AQ
A
R
D
-
P
Q
-
LA
A
WI
E
E
N
V
T
FP
C
TMVDRIVPAAT
P
E
T
L
Q
EI
A
D
Q
LGV
Y
DPCAI
A
CEPF
R
QWVIE
-----------
DNFV
N
GRP
D
W
DKV
G
A
Q
F
V
A
DV
V
P
F
E
M
MKLRMLNGSHSFLAYLGYL
G
G
YE
TI
A
D
T
V
T
N
PAY
R
K
AA
FA
LM
M
Q
EQAPTL
S
M
P
E
G
T
DL
NA
YA
TL
LI
E
RF
S
NP
S
L
R
H
R
TWQIAMDGSQK
-----
LPQRLL
DP
V
R
L
HL
Q
NG
G
S
W
RH
LALGVAGWMRY
TQ
GVD
EQ
GNAIDV
V
DP
M
--
L
A
E
F
Q
K
I
N
AQ
YQ
-----
GA
D
RV
K
ALL
G
L
SGI
F
A
DDLPQN
A
D
FV
G
AV
TA
A
Y
QQ
L
C
E
R
GARE
C
V
A
AL
fig|656419.3.peg.56
Escherichia coli M718 (13-486/486)
R
PSWDHSR
L
E
SRIVH
L
G
C
GAFHRAHQAL
Y
T
H
H
LLE
S
TD
S
DWGICEV
N
L
MP
G
N
D
RV
L
IEN
L
KK
Q
QL
LYTV
A
-----
EKGA
ES
TE
L
K
IIGS
M
K
E
--
A
L
H
P
E
I
D
GCEG
IL
NAMAR
PQ
T
AIVSLT
V
TEKGYC
A
D
A
A
S
G
Q
LD
L
N
NP
L
I
K
HDL
E
NP
TA
P
K
SA
I
G
Y
I
VEAL
RL
RRE
K
GLK
A
FTV
M
SCDN
V
RE
NGHV
A
K
V
AVLG
L
AQ
A
R
D
-
P
Q
-
LA
A
WI
E
E
N
V
T
FP
C
TMVDRIVPAAT
P
E
T
L
Q
EI
A
D
Q
LGV
Y
DPCAI
A
CEPF
R
QWVIE
-----------
DNFV
N
GRP
D
W
DKV
G
A
Q
F
V
A
DV
V
P
F
E
M
MKLRMLNGSHSFLAYLGYL
G
G
YE
TI
A
D
T
V
T
N
PAY
R
K
AA
FA
LM
M
Q
EQAPTL
S
M
P
E
G
T
DL
NA
YA
TL
LI
E
RF
S
NP
S
L
R
H
R
TWQIAMDGSQK
-----
LPQRLL
DP
V
R
L
HL
Q
NG
G
S
W
RH
LALGVAGWMRY
TQ
GVD
EQ
GNAIDV
V
DP
M
--
L
A
E
F
Q
K
I
N
AQ
YQ
-----
GA
D
RV
K
ALL
G
L
SGI
F
A
DDLPQN
A
D
FV
G
AV
TA
A
Y
QQ
L
C
E
R
GARE
C
V
A
AL
fig|749540.3.peg.3249
Escherichia coli MS 146-1 (13-486/486)
R
PSWDHSR
L
E
SRIVH
L
G
C
GAFHRAHQAL
Y
T
H
H
LLE
S
TD
S
DWGICEV
N
L
MP
G
N
D
RV
L
IEN
L
KK
Q
QL
LYTV
A
-----
EKGA
ES
TE
L
K
IIGS
M
K
E
--
A
L
H
P
E
I
D
GCEG
IL
NAMAR
PQ
T
AIVSLT
V
TEKGYC
A
D
A
A
S
G
Q
LD
L
N
NP
L
I
K
HDL
E
NP
TA
P
K
SA
I
G
Y
I
VEAL
RL
RRE
K
GLK
A
FTV
M
SCDN
V
RE
NGHV
A
K
V
AVLG
L
AQ
A
R
D
-
P
Q
-
LA
A
WI
E
E
N
V
T
FP
C
TMVDRIVPAAT
P
E
T
L
Q
EI
A
D
Q
LGV
Y
DPCAI
A
CEPF
R
QWVIE
-----------
DNFV
N
GRP
D
W
DKV
G
A
Q
F
V
A
DV
V
P
F
E
M
MKLRMLNGSHSFLAYLGYL
G
G
YE
TI
A
D
T
V
T
N
PAY
R
K
AA
FA
LM
M
Q
EQAPTL
S
M
P
E
G
T
DL
NA
YA
TL
LI
E
RF
S
NP
S
L
R
H
R
TWQIAMDGSQK
-----
LPQRLL
DP
V
R
L
HL
Q
NG
G
S
W
RH
LALGVAGWMRY
TQ
GVD
EQ
GNAIDV
V
DP
M
--
L
A
E
F
Q
K
I
N
AQ
YQ
-----
GA
D
RV
K
ALL
G
L
SGI
F
A
DDLPQN
A
D
FV
G
AV
TA
A
Y
QQ
L
C
E
R
GARE
C
V
A
AL
fig|749549.3.peg.3173
Escherichia coli MS 198-1 (13-486/486)
R
PSWDHSR
L
E
SRIVH
L
G
C
GAFHRAHQAL
Y
T
H
H
LLE
S
TD
S
DWGICEV
N
L
MP
G
N
D
RV
L
IEN
L
KK
Q
QL
LYTV
A
-----
EKGA
ES
TE
L
K
IIGS
M
K
E
--
A
L
H
P
E
I
D
GCEG
IL
NAMAR
PQ
T
AIVSLT
V
TEKGYC
A
D
A
A
S
G
Q
LD
L
N
NP
L
I
K
HDL
E
NP
TA
P
K
SA
I
G
Y
I
VEAL
RL
RRE
K
GLK
A
FTV
M
SCDN
V
RE
NGHV
A
K
V
AVLG
L
AQ
A
R
D
-
P
Q
-
LA
A
WI
E
E
N
V
T
FP
C
TMVDRIVPAAT
P
E
T
L
Q
EI
A
D
Q
LGV
Y
DPCAI
A
CEPF
R
QWVIE
-----------
DNFV
N
GRP
D
W
DKV
G
A
Q
F
V
A
DV
V
P
F
E
M
MKLRMLNGSHSFLAYLGYL
G
G
YE
TI
A
D
T
V
T
N
PAY
R
K
AA
FA
LM
M
Q
EQAPTL
S
M
P
E
G
T
DL
NA
YA
TL
LI
E
RF
S
NP
S
L
R
H
R
TWQIAMDGSQK
-----
LPQRLL
DP
V
R
L
HL
Q
NG
G
S
W
RH
LALGVAGWMRY
TQ
GVD
EQ
GNAIDV
V
DP
M
--
L
A
E
F
Q
K
I
N
AQ
YQ
-----
GA
D
RV
K
ALL
G
L
SGI
F
A
DDLPQN
A
D
FV
G
AV
TA
A
Y
QQ
L
C
E
R
GARE
C
V
A
AL
fig|585056.7.peg.5093
Escherichia coli UMN026 (13-486/486)
R
PSWDHSR
L
E
SRIVH
L
G
C
GAFHRAHQAL
Y
T
H
H
LLE
S
TD
S
DWGICEV
N
L
MP
G
N
D
RV
L
IEN
L
KK
Q
QL
LYTV
A
-----
EKGA
ES
TE
L
K
IIGS
M
K
E
--
A
L
H
P
E
I
D
GCEG
IL
NAMAR
PQ
T
AIVSLT
V
TEKGYC
A
D
A
A
S
G
Q
LD
L
N
NP
L
I
K
HDL
E
NP
TA
P
K
SA
I
G
Y
I
VEAL
RL
RRE
K
GLK
A
FTV
M
SCDN
V
RE
NGHV
A
K
V
AVLG
L
AQ
A
R
D
-
P
Q
-
LA
A
WI
E
E
N
V
T
FP
C
TMVDRIVPAAT
P
E
T
L
Q
EI
A
D
Q
LGV
Y
DPCAI
A
CEPF
R
QWVIE
-----------
DNFV
N
GRP
D
W
DKV
G
A
Q
F
V
A
DV
V
P
F
E
M
MKLRMLNGSHSFLAYLGYL
G
G
YE
TI
A
D
T
V
T
N
PAY
R
K
AA
FA
LM
M
Q
EQAPTL
S
M
P
E
G
T
DL
NA
YA
TL
LI
E
RF
S
NP
S
L
R
H
R
TWQIAMDGSQK
-----
LPQRLL
DP
V
R
L
HL
Q
NG
G
S
W
RH
LALGVAGWMRY
TQ
GVD
EQ
GNAIDV
V
DP
M
--
L
A
E
F
Q
K
I
N
AQ
YQ
-----
GA
D
RV
K
ALL
G
L
SGI
F
A
DDLPQN
A
D
FV
G
AV
TA
A
Y
QQ
L
C
E
R
GARE
C
V
A
AL
fig|316407.3.peg.4151
Escherichia coli W3110 (13-486/486)
R
PSWDHSR
L
E
SRIVH
L
G
C
GAFHRAHQAL
Y
T
H
H
LLE
S
TD
S
DWGICEV
N
L
MP
G
N
D
RV
L
IEN
L
KK
Q
QL
LYTV
A
-----
EKGA
ES
TE
L
K
IIGS
M
K
E
--
A
L
H
P
E
I
D
GCEG
IL
NAMAR
PQ
T
AIVSLT
V
TEKGYC
A
D
A
A
S
G
Q
LD
L
N
NP
L
I
K
HDL
E
NP
TA
P
K
SA
I
G
Y
I
VEAL
RL
RRE
K
GLK
A
FTV
M
SCDN
V
RE
NGHV
A
K
V
AVLG
L
AQ
A
R
D
-
P
Q
-
LA
A
WI
E
E
N
V
T
FP
C
TMVDRIVPAAT
P
E
T
L
Q
EI
A
D
Q
LGV
Y
DPCAI
A
CEPF
R
QWVIE
-----------
DNFV
N
GRP
D
W
DKV
G
A
Q
F
V
A
DV
V
P
F
E
M
MKLRMLNGSHSFLAYLGYL
G
G
YE
TI
A
D
T
V
T
N
PAY
R
K
AA
FA
LM
M
Q
EQAPTL
S
M
P
E
G
T
DL
NA
YA
TL
LI
E
RF
S
NP
S
L
R
H
R
TWQIAMDGSQK
-----
LPQRLL
DP
V
R
L
HL
Q
NG
G
S
W
RH
LALGVAGWMRY
TQ
GVD
EQ
GNAIDV
V
DP
M
--
L
A
E
F
Q
K
I
N
AQ
YQ
-----
GA
D
RV
K
ALL
G
L
SGI
F
A
DDLPQN
A
D
FV
G
AV
TA
A
Y
QQ
L
C
E
R
GARE
C
V
A
AL
fig|511145.12.peg.4464
Escherichia coli str. K-12 substr. MG1655 (13-486/486)
R
PSWDHSR
L
E
SRIVH
L
G
C
GAFHRAHQAL
Y
T
H
H
LLE
S
TD
S
DWGICEV
N
L
MP
G
N
D
RV
L
IEN
L
KK
Q
QL
LYTV
A
-----
EKGA
ES
TE
L
K
IIGS
M
K
E
--
A
L
H
P
E
I
D
GCEG
IL
NAMAR
PQ
T
AIVSLT
V
TEKGYC
A
D
A
A
S
G
Q
LD
L
N
NP
L
I
K
HDL
E
NP
TA
P
K
SA
I
G
Y
I
VEAL
RL
RRE
K
GLK
A
FTV
M
SCDN
V
RE
NGHV
A
K
V
AVLG
L
AQ
A
R
D
-
P
Q
-
LA
A
WI
E
E
N
V
T
FP
C
TMVDRIVPAAT
P
E
T
L
Q
EI
A
D
Q
LGV
Y
DPCAI
A
CEPF
R
QWVIE
-----------
DNFV
N
GRP
D
W
DKV
G
A
Q
F
V
A
DV
V
P
F
E
M
MKLRMLNGSHSFLAYLGYL
G
G
YE
TI
A
D
T
V
T
N
PAY
R
K
AA
FA
LM
M
Q
EQAPTL
S
M
P
E
G
T
DL
NA
YA
TL
LI
E
RF
S
NP
S
L
R
H
R
TWQIAMDGSQK
-----
LPQRLL
DP
V
R
L
HL
Q
NG
G
S
W
RH
LALGVAGWMRY
TQ
GVD
EQ
GNAIDV
V
DP
M
--
L
A
E
F
Q
K
I
N
AQ
YQ
-----
GA
D
RV
K
ALL
G
L
SGI
F
A
DDLPQN
A
D
FV
G
AV
TA
A
Y
QQ
L
C
E
R
GARE
C
V
A
AL
fig|511145.6.peg.4443
Escherichia coli str. K-12 substr. MG1655 (13-486/486)
R
PSWDHSR
L
E
SRIVH
L
G
C
GAFHRAHQAL
Y
T
H
H
LLE
S
TD
S
DWGICEV
N
L
MP
G
N
D
RV
L
IEN
L
KK
Q
QL
LYTV
A
-----
EKGA
ES
TE
L
K
IIGS
M
K
E
--
A
L
H
P
E
I
D
GCEG
IL
NAMAR
PQ
T
AIVSLT
V
TEKGYC
A
D
A
A
S
G
Q
LD
L
N
NP
L
I
K
HDL
E
NP
TA
P
K
SA
I
G
Y
I
VEAL
RL
RRE
K
GLK
A
FTV
M
SCDN
V
RE
NGHV
A
K
V
AVLG
L
AQ
A
R
D
-
P
Q
-
LA
A
WI
E
E
N
V
T
FP
C
TMVDRIVPAAT
P
E
T
L
Q
EI
A
D
Q
LGV
Y
DPCAI
A
CEPF
R
QWVIE
-----------
DNFV
N
GRP
D
W
DKV
G
A
Q
F
V
A
DV
V
P
F
E
M
MKLRMLNGSHSFLAYLGYL
G
G
YE
TI
A
D
T
V
T
N
PAY
R
K
AA
FA
LM
M
Q
EQAPTL
S
M
P
E
G
T
DL
NA
YA
TL
LI
E
RF
S
NP
S
L
R
H
R
TWQIAMDGSQK
-----
LPQRLL
DP
V
R
L
HL
Q
NG
G
S
W
RH
LALGVAGWMRY
TQ
GVD
EQ
GNAIDV
V
DP
M
--
L
A
E
F
Q
K
I
N
AQ
YQ
-----
GA
D
RV
K
ALL
G
L
SGI
F
A
DDLPQN
A
D
FV
G
AV
TA
A
Y
QQ
L
C
E
R
GARE
C
V
A
AL
fig|685038.3.peg.4450
Escherichia coli O83:H1 str. NRG 857C (13-486/486)
R
PSWDHSR
L
E
SRIVH
L
G
C
GAFHRAHQAL
Y
T
H
H
LLE
S
TD
S
DWGICEV
N
L
MP
G
N
D
RV
L
IEN
L
KK
Q
QL
LYTV
A
-----
EKGA
ES
TE
L
K
IIGS
M
K
E
--
A
L
H
P
E
I
D
GCEG
IL
NAMAR
PQ
T
AIVSLT
V
TEKGYC
A
D
A
A
S
G
Q
LD
L
N
NP
L
I
K
HDL
E
NP
TA
P
K
SA
I
G
Y
I
VEAL
RL
RRE
K
GLK
A
FTV
M
SCDN
V
RE
NGHV
A
K
V
AVLG
L
AQ
A
R
D
-
P
Q
-
LA
A
WI
E
E
N
V
T
FP
C
TMVDRIVPAAT
P
E
T
L
Q
EI
A
D
Q
Q
GV
Y
DPCAI
A
CEPF
R
QWVIE
-----------
DNFV
N
GRP
D
W
DKV
G
A
Q
F
V
A
DV
V
P
F
E
M
MKLRMLNGSHSFLAYLGYL
G
G
YE
TI
A
D
T
M
T
N
PAY
R
K
AA
FA
LM
M
Q
EQAPTL
S
M
P
E
G
T
DL
NA
YA
TL
LI
E
RF
S
NP
S
L
R
H
R
TWQIAMDGSQK
-----
LPQRLL
DP
V
R
L
HL
Q
NG
G
S
W
RH
LALGVAGWMRY
TQ
GVD
EQ
GNAIDV
V
DP
M
--
L
A
E
F
Q
K
I
N
AQ
YQ
-----
GA
D
RV
K
ALL
G
L
SGI
F
A
DDLPQN
A
D
FV
G
AV
TA
A
Y
QQ
L
C
E
R
GARE
C
V
A
AL
fig|405955.13.peg.4875
Escherichia coli APEC O1 (13-486/486)
R
PSWDHSR
L
E
SRIVH
L
G
C
GAFHRAHQAL
Y
T
H
H
LLE
S
TD
S
DWGICEV
N
L
MP
G
N
D
RV
L
IEN
L
KK
Q
QL
LYTV
A
-----
EKGA
ES
TE
L
K
IIGS
M
K
E
--
A
L
H
P
E
I
D
GCEG
IL
NAMAR
PQ
T
AIVSLT
V
TEKGYC
A
D
A
A
S
G
Q
LD
L
N
NP
L
I
K
HDL
E
NP
TA
P
K
SA
I
G
Y
I
VEAL
RL
RRE
K
GLK
A
FTV
M
SCDN
V
RE
NGHV
A
K
V
AVLG
L
A
L
A
R
D
-
P
Q
-
LA
A
WI
E
E
N
V
T
FP
C
TMVDRIVPAAT
P
E
T
L
Q
EI
A
D
Q
LGV
Y
DPCAI
A
CEPF
R
QWVIE
-----------
DNFV
N
GRP
D
W
DKV
G
A
Q
F
V
A
DV
V
P
F
E
M
MKLRMLNGSHSFLAYLGYL
G
G
YE
TI
A
D
T
M
T
N
PAY
R
K
AA
FA
LM
M
Q
EQAPTL
S
M
P
E
G
T
DL
NA
YA
TL
LI
E
RF
S
NP
S
L
R
H
R
TWQIAMDGSQK
-----
LPQRLL
DP
V
R
L
HL
Q
NG
G
S
W
RH
LALGVAGWMRY
TQ
GVD
EQ
GNAIDV
V
DP
M
--
M
A
E
F
Q
K
I
N
AQ
YQ
-----
GA
D
RV
K
ALL
G
L
SGI
F
A
DDLPQN
A
D
FV
G
AV
TA
A
Y
QQ
L
C
E
R
GARE
C
V
A
AL
fig|405955.9.peg.4107
Escherichia coli APEC O1 (13-486/486)
R
PSWDHSR
L
E
SRIVH
L
G
C
GAFHRAHQAL
Y
T
H
H
LLE
S
TD
S
DWGICEV
N
L
MP
G
N
D
RV
L
IEN
L
KK
Q
QL
LYTV
A
-----
EKGA
ES
TE
L
K
IIGS
M
K
E
--
A
L
H
P
E
I
D
GCEG
IL
NAMAR
PQ
T
AIVSLT
V
TEKGYC
A
D
A
A
S
G
Q
LD
L
N
NP
L
I
K
HDL
E
NP
TA
P
K
SA
I
G
Y
I
VEAL
RL
RRE
K
GLK
A
FTV
M
SCDN
V
RE
NGHV
A
K
V
AVLG
L
A
L
A
R
D
-
P
Q
-
LA
A
WI
E
E
N
V
T
FP
C
TMVDRIVPAAT
P
E
T
L
Q
EI
A
D
Q
LGV
Y
DPCAI
A
CEPF
R
QWVIE
-----------
DNFV
N
GRP
D
W
DKV
G
A
Q
F
V
A
DV
V
P
F
E
M
MKLRMLNGSHSFLAYLGYL
G
G
YE
TI
A
D
T
M
T
N
PAY
R
K
AA
FA
LM
M
Q
EQAPTL
S
M
P
E
G
T
DL
NA
YA
TL
LI
E
RF
S
NP
S
L
R
H
R
TWQIAMDGSQK
-----
LPQRLL
DP
V
R
L
HL
Q
NG
G
S
W
RH
LALGVAGWMRY
TQ
GVD
EQ
GNAIDV
V
DP
M
--
M
A
E
F
Q
K
I
N
AQ
YQ
-----
GA
D
RV
K
ALL
G
L
SGI
F
A
DDLPQN
A
D
FV
G
AV
TA
A
Y
QQ
L
C
E
R
GARE
C
V
A
AL
fig|714962.3.peg.4851
Escherichia coli IHE3034 (13-486/486)
R
PSWDHSR
L
E
SRIVH
L
G
C
GAFHRAHQAL
Y
T
H
H
LLE
S
TD
S
DWGICEV
N
L
MP
G
N
D
RV
L
IEN
L
KK
Q
QL
LYTV
A
-----
EKGA
ES
TE
L
K
IIGS
M
K
E
--
A
L
H
P
E
I
D
GCEG
IL
NAMAR
PQ
T
AIVSLT
V
TEKGYC
A
D
A
A
S
G
Q
LD
L
N
NP
L
I
K
HDL
E
NP
TA
P
K
SA
I
G
Y
I
VEAL
RL
RRE
K
GLK
A
FTV
M
SCDN
V
RE
NGHV
A
K
V
AVLG
L
A
L
A
R
D
-
P
Q
-
LA
A
WI
E
E
N
V
T
FP
C
TMVDRIVPAAT
P
E
T
L
Q
EI
A
D
Q
LGV
Y
DPCAI
A
CEPF
R
QWVIE
-----------
DNFV
N
GRP
D
W
DKV
G
A
Q
F
V
A
DV
V
P
F
E
M
MKLRMLNGSHSFLAYLGYL
G
G
YE
TI
A
D
T
M
T
N
PAY
R
K
AA
FA
LM
M
Q
EQAPTL
S
M
P
E
G
T
DL
NA
YA
TL
LI
E
RF
S
NP
S
L
R
H
R
TWQIAMDGSQK
-----
LPQRLL
DP
V
R
L
HL
Q
NG
G
S
W
RH
LALGVAGWMRY
TQ
GVD
EQ
GNAIDV
V
DP
M
--
M
A
E
F
Q
K
I
N
AQ
YQ
-----
GA
D
RV
K
ALL
G
L
SGI
F
A
DDLPQN
A
D
FV
G
AV
TA
A
Y
QQ
L
C
E
R
GARE
C
V
A
AL
fig|869729.3.peg.4794
Escherichia coli UM146 (13-486/486)
R
PSWDHSR
L
E
SRIVH
L
G
C
GAFHRAHQAL
Y
T
H
H
LLE
S
TD
S
DWGICEV
N
L
MP
G
N
D
RV
L
IEN
L
KK
Q
QL
LYTV
A
-----
EKGA
ES
TE
L
K
IIGS
M
K
E
--
A
L
H
P
E
I
D
GCEG
IL
NAMAR
PQ
T
AIVSLT
V
TEKGYC
A
D
A
A
S
G
Q
LD
L
N
NP
L
I
K
HDL
E
NP
TA
P
K
SA
I
G
Y
I
VEAL
RL
RRE
K
GLK
A
FTV
M
SCDN
V
RE
NGHV
A
K
V
AVLG
L
A
L
A
R
D
-
P
Q
-
LA
A
WI
E
E
N
V
T
FP
C
TMVDRIVPAAT
P
E
T
L
Q
EI
A
D
Q
LGV
Y
DPCAI
A
CEPF
R
QWVIE
-----------
DNFV
N
GRP
D
W
DKV
G
A
Q
F
V
A
DV
V
P
F
E
M
MKLRMLNGSHSFLAYLGYL
G
G
YE
TI
A
D
T
M
T
N
PAY
R
K
AA
FA
LM
M
Q
EQAPTL
S
M
P
E
G
T
DL
NA
YA
TL
LI
E
RF
S
NP
S
L
R
H
R
TWQIAMDGSQK
-----
LPQRLL
DP
V
R
L
HL
Q
NG
G
S
W
RH
LALGVAGWMRY
TQ
GVD
EQ
GNAIDV
V
DP
M
--
M
A
E
F
Q
K
I
N
AQ
YQ
-----
GA
D
RV
K
ALL
G
L
SGI
F
A
DDLPQN
A
D
FV
G
AV
TA
A
Y
QQ
L
C
E
R
GARE
C
V
A
AL
fig|364106.7.peg.4887
Escherichia coli UTI89 (13-486/486)
R
PSWDHSR
L
E
SRIVH
L
G
C
GAFHRAHQAL
Y
T
H
H
LLE
S
TD
S
DWGICEV
N
L
MP
G
N
D
RV
L
IEN
L
KK
Q
QL
LYTV
A
-----
EKGA
ES
TE
L
K
IIGS
M
K
E
--
A
L
H
P
E
I
D
GCEG
IL
NAMAR
PQ
T
AIVSLT
V
TEKGYC
A
D
A
A
S
G
Q
LD
L
N
NP
L
I
K
HDL
E
NP
TA
P
K
SA
I
G
Y
I
VEAL
RL
RRE
K
GLK
A
FTV
M
SCDN
V
RE
NGHV
A
K
V
AVLG
L
A
L
A
R
D
-
P
Q
-
LA
A
WI
E
E
N
V
T
FP
C
TMVDRIVPAAT
P
E
T
L
Q
EI
A
D
Q
LGV
Y
DPCAI
A
CEPF
R
QWVIE
-----------
DNFV
N
GRP
D
W
DKV
G
A
Q
F
V
A
DV
V
P
F
E
M
MKLRMLNGSHSFLAYLGYL
G
G
YE
TI
A
D
T
M
T
N
PAY
R
K
AA
FA
LM
M
Q
EQAPTL
S
M
P
E
G
T
DL
NA
YA
TL
LI
E
RF
S
NP
S
L
R
H
R
TWQIAMDGSQK
-----
LPQRLL
DP
V
R
L
HL
Q
NG
G
S
W
RH
LALGVAGWMRY
TQ
GVD
EQ
GNAIDV
V
DP
M
--
M
A
E
F
Q
K
I
N
AQ
YQ
-----
GA
D
RV
K
ALL
G
L
SGI
F
A
DDLPQN
A
D
FV
G
AV
TA
A
Y
QQ
L
C
E
R
GARE
C
V
A
AL
fig|364106.8.peg.4888
Escherichia coli UTI89 (13-486/486)
R
PSWDHSR
L
E
SRIVH
L
G
C
GAFHRAHQAL
Y
T
H
H
LLE
S
TD
S
DWGICEV
N
L
MP
G
N
D
RV
L
IEN
L
KK
Q
QL
LYTV
A
-----
EKGA
ES
TE
L
K
IIGS
M
K
E
--
A
L
H
P
E
I
D
GCEG
IL
NAMAR
PQ
T
AIVSLT
V
TEKGYC
A
D
A
A
S
G
Q
LD
L
N
NP
L
I
K
HDL
E
NP
TA
P
K
SA
I
G
Y
I
VEAL
RL
RRE
K
GLK
A
FTV
M
SCDN
V
RE
NGHV
A
K
V
AVLG
L
A
L
A
R
D
-
P
Q
-
LA
A
WI
E
E
N
V
T
FP
C
TMVDRIVPAAT
P
E
T
L
Q
EI
A
D
Q
LGV
Y
DPCAI
A
CEPF
R
QWVIE
-----------
DNFV
N
GRP
D
W
DKV
G
A
Q
F
V
A
DV
V
P
F
E
M
MKLRMLNGSHSFLAYLGYL
G
G
YE
TI
A
D
T
M
T
N
PAY
R
K
AA
FA
LM
M
Q
EQAPTL
S
M
P
E
G
T
DL
NA
YA
TL
LI
E
RF
S
NP
S
L
R
H
R
TWQIAMDGSQK
-----
LPQRLL
DP
V
R
L
HL
Q
NG
G
S
W
RH
LALGVAGWMRY
TQ
GVD
EQ
GNAIDV
V
DP
M
--
M
A
E
F
Q
K
I
N
AQ
YQ
-----
GA
D
RV
K
ALL
G
L
SGI
F
A
DDLPQN
A
D
FV
G
AV
TA
A
Y
QQ
L
C
E
R
GARE
C
V
A
AL
fig|6666666.5357.peg.44
Escherichia coli TY-2482
M
H
L
G
C
GAFHRAHQAL
Y
T
H
H
LLE
S
TD
S
DWGICEV
N
L
MP
G
N
D
RV
L
IEN
L
KK
Q
QL
LYTV
A
-----
EKGA
ES
TE
L
K
IIGS
M
K
E
--
A
L
H
P
E
I
D
GCEG
IL
NAMAR
PQ
T
AIVSLT
V
TEKGYC
A
D
A
A
S
G
Q
LD
L
N
NP
L
I
K
HDL
E
NP
TA
P
K
SA
I
G
Y
I
VEAL
RL
RRE
K
GLK
A
FTV
M
SCDN
V
RE
NGHV
A
K
V
AVLG
L
AQ
A
R
D
-
P
Q
-
LA
A
WI
E
E
N
V
T
FP
C
TMVDRIVPAAT
P
E
T
L
Q
EI
A
D
Q
LGV
Y
DPCAI
A
CEPF
R
QWVIE
-----------
DNFV
N
GRP
D
W
DKV
G
A
Q
F
V
A
DV
V
P
F
E
M
MKLRMLNGSHSFLAYLGYL
G
G
YE
TI
A
D
T
M
T
N
PDY
R
K
AA
FA
LM
M
Q
EQAPTL
S
M
P
E
G
T
DL
NA
YA
TL
LI
E
RF
S
NP
S
L
R
H
R
TWQIAMDGSQK
-----
LPQRLL
DP
V
R
L
HL
Q
NG
G
S
W
RH
LALGVAGWMRY
TQ
GVD
EQ
GNAIDV
V
DP
M
--
L
A
E
F
Q
K
I
N
AQ
YQ
-----
GA
D
RV
K
ALL
G
L
SGI
F
A
DDLPQN
A
D
FV
G
AV
TA
A
Y
QQ
L
C
E
R
GARE
C
V
A
AL
fig|550676.3.peg.2472
Escherichia coli B185 (22-482/488)
QL
Q
SRIVHFG
F
GAFHRAHQAL
L
TD
R
V
L
N
A
QG
G
DWGICE
I
S
L
FS
G
D
Q
--
L
MSQ
L
RA
Q
NH
LYTV
L
-----
EKGA
DG
N
Q
A
I
I
V
G
A
V
H
E
--
C
L
N
A
K
L
D
SLAA
I
I
EKFCE
PQ
V
AIVSLT
I
TEKGYC
I
D
P
A
T
G
A
LD
T
S
NP
R
I
I
HDL
Q
T
P
EE
P
H
SA
P
G
I
LVEAL
KR
RRE
R
GL
T
P
FTV
L
SCDNI
PD
NGHV
V
K
N
AVLG
M
A
E
K
R
S
-
PE
-
LA
G
WI
K
E
H
VSFP
G
TMVDRIVPAAT
D
E
S
LAEI
S
Q
H
LGV
N
DPCAI
S
CEPF
I
QWV
V
E
-----------
DNFV
A
GRP
A
W
EVA
GVQ
M
V
N
DV
L
P
W
EEMKLRMLNGSHSFLAYLGYL
S
G
FA
H
I
S
D
C
M
Q
D
RAF
R
H
AA
RT
LM
L
D
EQAPTL
R
I
K
D
-
V
DL
TQ
YA
DK
LI
A
RF
A
NP
A
LKH
K
TWQIAMDGSQK
-----
LPQR
M
LAG
I
R
I
HL
G
R
K
T
D
W
SL
LALGVAGWMRY
VS
GVD
DA
GNAIDV
R
DP
L
--
S
D
K
I
R
D
L
V
A
G
SS
-----
SE
Q
RV
T
ALL
S
L
REV
F
G
DDLP
D
NP
H
FV
Q
A
I
EQ
A
W
QQI
A
Q
F
GA
HQ
A
L
fig|656393.3.peg.3206
Escherichia coli H299 (22-482/488)
QL
Q
SRIVHFG
F
GAFHRAHQAL
L
TD
R
V
L
N
A
QG
G
DWGICE
I
S
L
FS
G
D
Q
--
L
MSQ
L
RA
Q
NH
LYTV
L
-----
EKGA
DG
N
Q
A
I
I
V
G
A
V
H
E
--
C
L
N
A
K
L
D
SLAA
I
I
EKFCE
PQ
V
AIVSLT
I
TEKGYC
I
D
P
A
T
G
A
LD
T
S
NP
R
I
I
HDL
Q
NP
EE
P
H
SA
P
G
I
LVEAL
KR
RRE
R
GL
A
P
FTV
L
SCDNI
PD
NGHV
V
K
N
AVLG
M
A
E
K
R
S
-
PE
-
LA
G
WI
K
E
H
VSFP
G
TMVDRIVPAAT
D
E
S
LAEI
S
Q
H
LGV
N
DPCAI
S
CEPF
I
QWV
V
E
-----------
DNFV
A
GRP
A
W
EVA
GVQ
M
V
N
DV
L
P
W
EEMKLRMLNGSHSFLAYLGYL
S
G
FA
H
I
S
D
C
M
Q
D
RAF
R
H
AA
RT
LM
L
D
EQAPTL
R
I
K
D
-
V
DL
TQ
YA
DK
LI
A
RF
A
NP
A
LKH
K
TWQIAMDGSQK
-----
LPQR
M
LAG
I
R
I
HL
A
RE
T
D
W
SL
LALGVAGWMRY
VS
GVD
DA
GN
T
IDV
R
DP
L
--
S
D
K
I
R
D
L
V
A
G
SS
-----
SE
Q
RV
T
ALL
S
L
REV
F
G
DDLP
D
NP
H
FV
Q
A
I
EQ
A
W
QQI
A
Q
F
GA
HQ
A
L
fig|701177.3.peg.2739
Escherichia coli O55:H7 str. CB9615 (22-482/488)
QL
Q
SRIVHFG
F
GAFHRAHQAL
L
TD
R
V
L
N
A
QG
G
DWGICE
I
S
L
FS
G
D
Q
--
L
MSQ
L
RA
Q
NH
LYTV
L
-----
EKGA
DG
N
Q
A
I
I
V
G
A
V
H
E
--
C
L
N
A
K
L
D
SLAA
I
I
EKFCE
PQ
V
AIVSLT
I
TEKGYC
I
D
P
A
T
G
A
LD
T
S
NP
R
I
I
HDL
Q
T
P
EE
P
H
SA
P
G
I
LVEAL
KR
RRE
R
GL
T
P
FTV
L
SCDNI
PD
NGHV
V
K
N
AVLG
M
A
E
K
R
S
-
PE
-
LA
G
WI
K
E
H
VSFP
G
TMVDRIVPAAT
D
E
S
LAEI
S
Q
H
LGV
N
DPCAI
S
CEPF
I
QWV
V
E
-----------
DNFV
A
GRP
A
W
EVA
GVQ
M
V
N
DV
L
P
W
EEMKLRMLNGSHSFLAYLGYL
S
G
FA
H
I
S
D
C
M
Q
D
RAF
R
H
AA
RT
LM
L
D
EQAPTL
R
I
K
D
-
V
DL
TQ
YA
DK
LI
A
RF
A
NP
A
LKH
K
TWQIAMDGSQK
-----
LPQR
M
LAG
I
R
I
HL
G
RE
T
D
W
SL
LALGVAGWMRY
VS
GVD
DA
GNAIDV
R
DP
L
--
S
D
K
I
R
D
L
V
A
G
SI
-----
SE
Q
RV
T
ALL
S
L
REV
F
G
DDLP
D
NP
H
FV
Q
A
I
EQ
A
W
QQI
A
Q
F
GA
HQ
A
L
fig|562.371.peg.5034
Escherichia coli 1044A (22-482/488)
QL
Q
SRIVHFG
F
GAFHRAHQAL
L
TD
R
V
L
N
A
QG
G
DWGICE
I
S
L
FS
G
D
Q
--
L
MSQ
L
RA
Q
NH
LYTV
L
-----
EKGA
DG
N
Q
A
I
I
V
G
A
V
H
E
--
C
L
N
A
K
L
D
SLAA
I
I
EKFCE
PQ
V
AIVSLT
I
TEKGYC
I
D
P
A
T
G
A
LD
T
S
NP
R
I
I
HDL
Q
T
P
EE
P
H
SA
P
G
I
LVEAL
KR
RRE
R
GL
T
P
FTV
L
SCDNI
PD
NGHV
V
K
N
AVLG
M
A
E
K
R
S
-
PE
-
LA
G
WI
K
E
H
VSFP
G
TMVDRIVPAAT
D
E
S
LAEI
S
Q
H
LGV
N
DPCAI
S
CEPF
I
QWV
V
E
-----------
DNFV
A
GRP
A
W
EVA
GVQ
M
V
N
DV
L
P
W
EEMKLRMLNGSHSFLAYLGYL
S
G
FA
H
I
S
D
C
M
Q
D
RAF
R
H
AA
RT
LM
L
D
EQAPTL
R
I
K
D
-
V
DL
TQ
YA
DK
LI
A
RF
A
NP
A
LKH
K
TWQIAMDGSQK
-----
LPQR
M
LAG
I
R
I
HL
G
RE
T
D
W
SL
LALGVAGWMRY
VS
GVD
DA
GNAIDV
R
DP
L
--
S
D
K
I
R
D
L
V
A
G
SI
-----
SE
Q
RV
T
ALL
S
L
REV
F
G
DDLP
D
NP
H
FV
Q
A
I
EQ
A
R
QQI
A
Q
F
GA
HQ
A
L
fig|562.373.peg.3923
Escherichia coli 1125A (22-482/488)
QL
Q
SRIVHFG
F
GAFHRAHQAL
L
TD
R
V
L
N
A
QG
G
DWGICE
I
S
L
FS
G
D
Q
--
L
MSQ
L
RA
Q
NH
LYTV
L
-----
EKGA
DG
N
Q
A
I
I
V
G
A
V
H
E
--
C
L
N
A
K
L
D
SLAA
I
I
EKFCE
PQ
V
AIVSLT
I
TEKGYC
I
D
P
A
T
G
A
LD
T
S
NP
R
I
I
HDL
Q
T
P
EE
P
H
SA
P
G
I
LVEAL
KR
RRE
R
GL
T
P
FTV
L
SCDNI
PD
NGHV
V
K
N
AVLG
M
A
E
K
R
S
-
PE
-
LA
G
WI
K
E
H
VSFP
G
TMVDRIVPAAT
D
E
S
LAEI
S
Q
H
LGV
N
DPCAI
S
CEPF
I
QWV
V
E
-----------
DNFV
A
GRP
A
W
EVA
GVQ
M
V
N
DV
L
P
W
EEMKLRMLNGSHSFLAYLGYL
S
G
FA
H
I
S
D
C
M
Q
D
RAF
R
H
AA
RT
LM
L
D
EQAPTL
R
I
K
D
-
V
DL
TQ
YA
DK
LI
A
RF
A
NP
A
LKH
K
TWQIAMDGSQK
-----
LPQR
M
LAG
I
R
I
HL
G
RE
T
D
W
SL
LALGVAGWMRY
VS
GVD
DA
GNAIDV
R
DP
L
--
S
D
K
I
R
D
L
V
A
G
SI
-----
SE
Q
RV
T
ALL
S
L
REV
F
G
DDLP
D
NP
H
FV
Q
A
I
EQ
A
R
QQI
A
Q
F
GA
HQ
A
L
fig|562.372.peg.5595
Escherichia coli 1212A (22-482/488)
QL
Q
SRIVHFG
F
GAFHRAHQAL
L
TD
R
V
L
N
A
QG
G
DWGICE
I
S
L
FS
G
D
Q
--
L
MSQ
L
RA
Q
NH
LYTV
L
-----
EKGA
DG
N
Q
A
I
I
V
G
A
V
H
E
--
C
L
N
A
K
L
D
SLAA
I
I
EKFCE
PQ
V
AIVSLT
I
TEKGYC
I
D
P
A
T
G
A
LD
T
S
NP
R
I
I
HDL
Q
T
P
EE
P
H
SA
P
G
I
LVEAL
KR
RRE
R
GL
T
P
FTV
L
SCDNI
PD
NGHV
V
K
N
AVLG
M
A
E
K
R
S
-
PE
-
LA
G
WI
K
E
H
VSFP
G
TMVDRIVPAAT
D
E
S
LAEI
S
Q
H
LGV
N
DPCAI
S
CEPF
I
QWV
V
E
-----------
DNFV
A
GRP
A
W
EVA
GVQ
M
V
N
DV
L
P
W
EEMKLRMLNGSHSFLAYLGYL
S
G
FA
H
I
S
D
C
M
Q
D
RAF
R
H
AA
RT
LM
L
D
EQAPTL
R
I
K
D
-
V
DL
TQ
YA
DK
LI
A
RF
A
NP
A
LKH
K
TWQIAMDGSQK
-----
LPQR
M
LAG
I
R
I
HL
G
RE
T
D
W
SL
LALGVAGWMRY
VS
GVD
DA
GNAIDV
R
DP
L
--
S
D
K
I
R
D
L
V
A
G
SI
-----
SE
Q
RV
T
ALL
S
L
REV
F
G
DDLP
D
NP
H
FV
Q
A
I
EQ
A
R
QQI
A
Q
F
GA
HQ
A
L
fig|562.374.peg.3323
Escherichia coli 536A (22-482/488)
QL
Q
SRIVHFG
F
GAFHRAHQAL
L
TD
R
V
L
N
A
QG
G
DWGICE
I
S
L
FS
G
D
Q
--
L
MSQ
L
RA
Q
NH
LYTV
L
-----
EKGA
DG
N
Q
A
I
I
V
G
A
V
H
E
--
C
L
N
A
K
L
D
SLAA
I
I
EKFCE
PQ
V
AIVSLT
I
TEKGYC
I
D
P
A
T
G
A
LD
T
S
NP
R
I
I
HDL
Q
T
P
EE
P
H
SA
P
G
I
LVEAL
KR
RRE
R
GL
T
P
FTV
L
SCDNI
PD
NGHV
V
K
N
AVLG
M
A
E
K
R
S
-
PE
-
LA
G
WI
K
E
H
VSFP
G
TMVDRIVPAAT
D
E
S
LAEI
S
Q
H
LGV
N
DPCAI
S
CEPF
I
QWV
V
E
-----------
DNFV
A
GRP
A
W
EVA
GVQ
M
V
N
DV
L
P
W
EEMKLRMLNGSHSFLAYLGYL
S
G
FA
H
I
S
D
C
M
Q
D
RAF
R
H
AA
RT
LM
L
D
EQAPTL
R
I
K
D
-
V
DL
TQ
YA
DK
LI
A
RF
A
NP
A
LKH
K
TWQIAMDGSQK
-----
LPQR
M
LAG
I
R
I
HL
G
RE
T
D
W
SL
LALGVAGWMRY
VS
GVD
DA
GNAIDV
R
DP
L
--
S
D
K
I
R
D
L
V
A
G
SI
-----
SE
Q
RV
T
ALL
S
L
REV
F
G
DDLP
D
NP
H
FV
Q
A
I
EQ
A
R
QQI
A
Q
F
GA
HQ
A
L
fig|83334.1.peg.3058
Escherichia coli O157:H7 (22-482/488)
QL
Q
SRIVHFG
F
GAFHRAHQAL
L
TD
R
V
L
N
A
QG
G
DWGICE
I
S
L
FS
G
D
Q
--
L
MSQ
L
RA
Q
NH
LYTV
L
-----
EKGA
DG
N
Q
A
I
I
V
G
A
V
H
E
--
C
L
N
A
K
L
D
SLAA
I
I
EKFCE
PQ
V
AIVSLT
I
TEKGYC
I
D
P
A
T
G
A
LD
T
S
NP
R
I
I
HDL
Q
T
P
EE
P
H
SA
P
G
I
LVEAL
KR
RRE
R
GL
T
P
FTV
L
SCDNI
PD
NGHV
V
K
N
AVLG
M
A
E
K
R
S
-
PE
-
LA
G
WI
K
E
H
VSFP
G
TMVDRIVPAAT
D
E
S
LAEI
S
Q
H
LGV
N
DPCAI
S
CEPF
I
QWV
V
E
-----------
DNFV
A
GRP
A
W
EVA
GVQ
M
V
N
DV
L
P
W
EEMKLRMLNGSHSFLAYLGYL
S
G
FA
H
I
S
D
C
M
Q
D
RAF
R
H
AA
RT
LM
L
D
EQAPTL
R
I
K
D
-
V
DL
TQ
YA
DK
LI
A
RF
A
NP
A
LKH
K
TWQIAMDGSQK
-----
LPQR
M
LAG
I
R
I
HL
G
RE
T
D
W
SL
LALGVAGWMRY
VS
GVD
DA
GNAIDV
R
DP
L
--
S
D
K
I
R
D
L
V
A
G
SI
-----
SE
Q
RV
T
ALL
S
L
REV
F
G
DDLP
D
NP
H
FV
Q
A
I
EQ
A
R
QQI
A
Q
F
GA
HQ
A
L
fig|155864.1.peg.3063
Escherichia coli O157:H7 EDL933 (22-482/488)
QL
Q
SRIVHFG
F
GAFHRAHQAL
L
TD
R
V
L
N
A
QG
G
DWGICE
I
S
L
FS
G
D
Q
--
L
MSQ
L
RA
Q
NH
LYTV
L
-----
EKGA
DG
N
Q
A
I
I
V
G
A
V
H
E
--
C
L
N
A
K
L
D
SLAA
I
I
EKFCE
PQ
V
AIVSLT
I
TEKGYC
I
D
P
A
T
G
A
LD
T
S
NP
R
I
I
HDL
Q
T
P
EE
P
H
SA
P
G
I
LVEAL
KR
RRE
R
GL
T
P
FTV
L
SCDNI
PD
NGHV
V
K
N
AVLG
M
A
E
K
R
S
-
PE
-
LA
G
WI
K
E
H
VSFP
G
TMVDRIVPAAT
D
E
S
LAEI
S
Q
H
LGV
N
DPCAI
S
CEPF
I
QWV
V
E
-----------
DNFV
A
GRP
A
W
EVA
GVQ
M
V
N
DV
L
P
W
EEMKLRMLNGSHSFLAYLGYL
S
G
FA
H
I
S
D
C
M
Q
D
RAF
R
H
AA
RT
LM
L
D
EQAPTL
R
I
K
D
-
V
DL
TQ
YA
DK
LI
A
RF
A
NP
A
LKH
K
TWQIAMDGSQK
-----
LPQR
M
LAG
I
R
I
HL
G
RE
T
D
W
SL
LALGVAGWMRY
VS
GVD
DA
GNAIDV
R
DP
L
--
S
D
K
I
R
D
L
V
A
G
SI
-----
SE
Q
RV
T
ALL
S
L
REV
F
G
DDLP
D
NP
H
FV
Q
A
I
EQ
A
R
QQI
A
Q
F
GA
HQ
A
L
fig|155864.8.peg.2955
Escherichia coli O157:H7 EDL933 (22-482/488)
QL
Q
SRIVHFG
F
GAFHRAHQAL
L
TD
R
V
L
N
A
QG
G
DWGICE
I
S
L
FS
G
D
Q
--
L
MSQ
L
RA
Q
NH
LYTV
L
-----
EKGA
DG
N
Q
A
I
I
V
G
A
V
H
E
--
C
L
N
A
K
L
D
SLAA
I
I
EKFCE
PQ
V
AIVSLT
I
TEKGYC
I
D
P
A
T
G
A
LD
T
S
NP
R
I
I
HDL
Q
T
P
EE
P
H
SA
P
G
I
LVEAL
KR
RRE
R
GL
T
P
FTV
L
SCDNI
PD
NGHV
V
K
N
AVLG
M
A
E
K
R
S
-
PE
-
LA
G
WI
K
E
H
VSFP
G
TMVDRIVPAAT
D
E
S
LAEI
S
Q
H
LGV
N
DPCAI
S
CEPF
I
QWV
V
E
-----------
DNFV
A
GRP
A
W
EVA
GVQ
M
V
N
DV
L
P
W
EEMKLRMLNGSHSFLAYLGYL
S
G
FA
H
I
S
D
C
M
Q
D
RAF
R
H
AA
RT
LM
L
D
EQAPTL
R
I
K
D
-
V
DL
TQ
YA
DK
LI
A
RF
A
NP
A
LKH
K
TWQIAMDGSQK
-----
LPQR
M
LAG
I
R
I
HL
G
RE
T
D
W
SL
LALGVAGWMRY
VS
GVD
DA
GNAIDV
R
DP
L
--
S
D
K
I
R
D
L
V
A
G
SI
-----
SE
Q
RV
T
ALL
S
L
REV
F
G
DDLP
D
NP
H
FV
Q
A
I
EQ
A
R
QQI
A
Q
F
GA
HQ
A
L
fig|444454.5.peg.1988
Escherichia coli O157:H7 str. EC4024 (22-482/488)
QL
Q
SRIVHFG
F
GAFHRAHQAL
L
TD
R
V
L
N
A
QG
G
DWGICE
I
S
L
FS
G
D
Q
--
L
MSQ
L
RA
Q
NH
LYTV
L
-----
EKGA
DG
N
Q
A
I
I
V
G
A
V
H
E
--
C
L
N
A
K
L
D
SLAA
I
I
EKFCE
PQ
V
AIVSLT
I
TEKGYC
I
D
P
A
T
G
A
LD
T
S
NP
R
I
I
HDL
Q
T
P
EE
P
H
SA
P
G
I
LVEAL
KR
RRE
R
GL
T
P
FTV
L
SCDNI
PD
NGHV
V
K
N
AVLG
M
A
E
K
R
S
-
PE
-
LA
G
WI
K
E
H
VSFP
G
TMVDRIVPAAT
D
E
S
LAEI
S
Q
H
LGV
N
DPCAI
S
CEPF
I
QWV
V
E
-----------
DNFV
A
GRP
A
W
EVA
GVQ
M
V
N
DV
L
P
W
EEMKLRMLNGSHSFLAYLGYL
S
G
FA
H
I
S
D
C
M
Q
D
RAF
R
H
AA
RT
LM
L
D
EQAPTL
R
I
K
D
-
V
DL
TQ
YA
DK
LI
A
RF
A
NP
A
LKH
K
TWQIAMDGSQK
-----
LPQR
M
LAG
I
R
I
HL
G
RE
T
D
W
SL
LALGVAGWMRY
VS
GVD
DA
GNAIDV
R
DP
L
--
S
D
K
I
R
D
L
V
A
G
SI
-----
SE
Q
RV
T
ALL
S
L
REV
F
G
DDLP
D
NP
H
FV
Q
A
I
EQ
A
R
QQI
A
Q
F
GA
HQ
A
L
fig|444449.5.peg.1449
Escherichia coli O157:H7 str. EC4042 (22-482/488)
QL
Q
SRIVHFG
F
GAFHRAHQAL
L
TD
R
V
L
N
A
QG
G
DWGICE
I
S
L
FS
G
D
Q
--
L
MSQ
L
RA
Q
NH
LYTV
L
-----
EKGA
DG
N
Q
A
I
I
V
G
A
V
H
E
--
C
L
N
A
K
L
D
SLAA
I
I
EKFCE
PQ
V
AIVSLT
I
TEKGYC
I
D
P
A
T
G
A
LD
T
S
NP
R
I
I
HDL
Q
T
P
EE
P
H
SA
P
G
I
LVEAL
KR
RRE
R
GL
T
P
FTV
L
SCDNI
PD
NGHV
V
K
N
AVLG
M
A
E
K
R
S
-
PE
-
LA
G
WI
K
E
H
VSFP
G
TMVDRIVPAAT
D
E
S
LAEI
S
Q
H
LGV
N
DPCAI
S
CEPF
I
QWV
V
E
-----------
DNFV
A
GRP
A
W
EVA
GVQ
M
V
N
DV
L
P
W
EEMKLRMLNGSHSFLAYLGYL
S
G
FA
H
I
S
D
C
M
Q
D
RAF
R
H
AA
RT
LM
L
D
EQAPTL
R
I
K
D
-
V
DL
TQ
YA
DK
LI
A
RF
A
NP
A
LKH
K
TWQIAMDGSQK
-----
LPQR
M
LAG
I
R
I
HL
G
RE
T
D
W
SL
LALGVAGWMRY
VS
GVD
DA
GNAIDV
R
DP
L
--
S
D
K
I
R
D
L
V
A
G
SI
-----
SE
Q
RV
T
ALL
S
L
REV
F
G
DDLP
D
NP
H
FV
Q
A
I
EQ
A
R
QQI
A
Q
F
GA
HQ
A
L
fig|444448.5.peg.211
Escherichia coli O157:H7 str. EC4045 (22-482/488)
QL
Q
SRIVHFG
F
GAFHRAHQAL
L
TD
R
V
L
N
A
QG
G
DWGICE
I
S
L
FS
G
D
Q
--
L
MSQ
L
RA
Q
NH
LYTV
L
-----
EKGA
DG
N
Q
A
I
I
V
G
A
V
H
E
--
C
L
N
A
K
L
D
SLAA
I
I
EKFCE
PQ
V
AIVSLT
I
TEKGYC
I
D
P
A
T
G
A
LD
T
S
NP
R
I
I
HDL
Q
T
P
EE
P
H
SA
P
G
I
LVEAL
KR
RRE
R
GL
T
P
FTV
L
SCDNI
PD
NGHV
V
K
N
AVLG
M
A
E
K
R
S
-
PE
-
LA
G
WI
K
E
H
VSFP
G
TMVDRIVPAAT
D
E
S
LAEI
S
Q
H
LGV
N
DPCAI
S
CEPF
I
QWV
V
E
-----------
DNFV
A
GRP
A
W
EVA
GVQ
M
V
N
DV
L
P
W
EEMKLRMLNGSHSFLAYLGYL
S
G
FA
H
I
S
D
C
M
Q
D
RAF
R
H
AA
RT
LM
L
D
EQAPTL
R
I
K
D
-
V
DL
TQ
YA
DK
LI
A
RF
A
NP
A
LKH
K
TWQIAMDGSQK
-----
LPQR
M
LAG
I
R
I
HL
G
RE
T
D
W
SL
LALGVAGWMRY
VS
GVD
DA
GNAIDV
R
DP
L
--
S
D
K
I
R
D
L
V
A
G
SI
-----
SE
Q
RV
T
ALL
S
L
REV
F
G
DDLP
D
NP
H
FV
Q
A
I
EQ
A
R
QQI
A
Q
F
GA
HQ
A
L
fig|444453.5.peg.1557
Escherichia coli O157:H7 str. EC4076 (22-482/488)
QL
Q
SRIVHFG
F
GAFHRAHQAL
L
TD
R
V
L
N
A
QG
G
DWGICE
I
S
L
FS
G
D
Q
--
L
MSQ
L
RA
Q
NH
LYTV
L
-----
EKGA
DG
N
Q
A
I
I
V
G
A
V
H
E
--
C
L
N
A
K
L
D
SLAA
I
I
EKFCE
PQ
V
AIVSLT
I
TEKGYC
I
D
P
A
T
G
A
LD
T
S
NP
R
I
I
HDL
Q
T
P
EE
P
H
SA
P
G
I
LVEAL
KR
RRE
R
GL
T
P
FTV
L
SCDNI
PD
NGHV
V
K
N
AVLG
M
A
E
K
R
S
-
PE
-
LA
G
WI
K
E
H
VSFP
G
TMVDRIVPAAT
D
E
S
LAEI
S
Q
H
LGV
N
DPCAI
S
CEPF
I
QWV
V
E
-----------
DNFV
A
GRP
A
W
EVA
GVQ
M
V
N
DV
L
P
W
EEMKLRMLNGSHSFLAYLGYL
S
G
FA
H
I
S
D
C
M
Q
D
RAF
R
H
AA
RT
LM
L
D
EQAPTL
R
I
K
D
-
V
DL
TQ
YA
DK
LI
A
RF
A
NP
A
LKH
K
TWQIAMDGSQK
-----
LPQR
M
LAG
I
R
I
HL
G
RE
T
D
W
SL
LALGVAGWMRY
VS
GVD
DA
GNAIDV
R
DP
L
--
S
D
K
I
R
D
L
V
A
G
SI
-----
SE
Q
RV
T
ALL
S
L
REV
F
G
DDLP
D
NP
H
FV
Q
A
I
EQ
A
R
QQI
A
Q
F
GA
HQ
A
L
fig|444452.5.peg.2575
Escherichia coli O157:H7 str. EC4113 (22-482/488)
QL
Q
SRIVHFG
F
GAFHRAHQAL
L
TD
R
V
L
N
A
QG
G
DWGICE
I
S
L
FS
G
D
Q
--
L
MSQ
L
RA
Q
NH
LYTV
L
-----
EKGA
DG
N
Q
A
I
I
V
G
A
V
H
E
--
C
L
N
A
K
L
D
SLAA
I
I
EKFCE
PQ
V
AIVSLT
I
TEKGYC
I
D
P
A
T
G
A
LD
T
S
NP
R
I
I
HDL
Q
T
P
EE
P
H
SA
P
G
I
LVEAL
KR
RRE
R
GL
T
P
FTV
L
SCDNI
PD
NGHV
V
K
N
AVLG
M
A
E
K
R
S
-
PE
-
LA
G
WI
K
E
H
VSFP
G
TMVDRIVPAAT
D
E
S
LAEI
S
Q
H
LGV
N
DPCAI
S
CEPF
I
QWV
V
E
-----------
DNFV
A
GRP
A
W
EVA
GVQ
M
V
N
DV
L
P
W
EEMKLRMLNGSHSFLAYLGYL
S
G
FA
H
I
S
D
C
M
Q
D
RAF
R
H
AA
RT
LM
L
D
EQAPTL
R
I
K
D
-
V
DL
TQ
YA
DK
LI
A
RF
A
NP
A
LKH
K
TWQIAMDGSQK
-----
LPQR
M
LAG
I
R
I
HL
G
RE
T
D
W
SL
LALGVAGWMRY
VS
GVD
DA
GNAIDV
R
DP
L
--
S
D
K
I
R
D
L
V
A
G
SI
-----
SE
Q
RV
T
ALL
S
L
REV
F
G
DDLP
D
NP
H
FV
Q
A
I
EQ
A
R
QQI
A
Q
F
GA
HQ
A
L
fig|444450.8.peg.3301
Escherichia coli O157:H7 str. EC4115 (22-482/488)
QL
Q
SRIVHFG
F
GAFHRAHQAL
L
TD
R
V
L
N
A
QG
G
DWGICE
I
S
L
FS
G
D
Q
--
L
MSQ
L
RA
Q
NH
LYTV
L
-----
EKGA
DG
N
Q
A
I
I
V
G
A
V
H
E
--
C
L
N
A
K
L
D
SLAA
I
I
EKFCE
PQ
V
AIVSLT
I
TEKGYC
I
D
P
A
T
G
A
LD
T
S
NP
R
I
I
HDL
Q
T
P
EE
P
H
SA
P
G
I
LVEAL
KR
RRE
R
GL
T
P
FTV
L
SCDNI
PD
NGHV
V
K
N
AVLG
M
A
E
K
R
S
-
PE
-
LA
G
WI
K
E
H
VSFP
G
TMVDRIVPAAT
D
E
S
LAEI
S
Q
H
LGV
N
DPCAI
S
CEPF
I
QWV
V
E
-----------
DNFV
A
GRP
A
W
EVA
GVQ
M
V
N
DV
L
P
W
EEMKLRMLNGSHSFLAYLGYL
S
G
FA
H
I
S
D
C
M
Q
D
RAF
R
H
AA
RT
LM
L
D
EQAPTL
R
I
K
D
-
V
DL
TQ
YA
DK
LI
A
RF
A
NP
A
LKH
K
TWQIAMDGSQK
-----
LPQR
M
LAG
I
R
I
HL
G
RE
T
D
W
SL
LALGVAGWMRY
VS
GVD
DA
GNAIDV
R
DP
L
--
S
D
K
I
R
D
L
V
A
G
SI
-----
SE
Q
RV
T
ALL
S
L
REV
F
G
DDLP
D
NP
H
FV
Q
A
I
EQ
A
R
QQI
A
Q
F
GA
HQ
A
L
fig|444451.5.peg.825
Escherichia coli O157:H7 str. EC4196 (22-482/488)
QL
Q
SRIVHFG
F
GAFHRAHQAL
L
TD
R
V
L
N
A
QG
G
DWGICE
I
S
L
FS
G
D
Q
--
L
MSQ
L
RA
Q
NH
LYTV
L
-----
EKGA
DG
N
Q
A
I
I
V
G
A
V
H
E
--
C
L
N
A
K
L
D
SLAA
I
I
EKFCE
PQ
V
AIVSLT
I
TEKGYC
I
D
P
A
T
G
A
LD
T
S
NP
R
I
I
HDL
Q
T
P
EE
P
H
SA
P
G
I
LVEAL
KR
RRE
R
GL
T
P
FTV
L
SCDNI
PD
NGHV
V
K
N
AVLG
M
A
E
K
R
S
-
PE
-
LA
G
WI
K
E
H
VSFP
G
TMVDRIVPAAT
D
E
S
LAEI
S
Q
H
LGV
N
DPCAI
S
CEPF
I
QWV
V
E
-----------
DNFV
A
GRP
A
W
EVA
GVQ
M
V
N
DV
L
P
W
EEMKLRMLNGSHSFLAYLGYL
S
G
FA
H
I
S
D
C
M
Q
D
RAF
R
H
AA
RT
LM
L
D
EQAPTL
R
I
K
D
-
V
DL
TQ
YA
DK
LI
A
RF
A
NP
A
LKH
K
TWQIAMDGSQK
-----
LPQR
M
LAG
I
R
I
HL
G
RE
T
D
W
SL
LALGVAGWMRY
VS
GVD
DA
GNAIDV
R
DP
L
--
S
D
K
I
R
D
L
V
A
G
SI
-----
SE
Q
RV
T
ALL
S
L
REV
F
G
DDLP
D
NP
H
FV
Q
A
I
EQ
A
R
QQI
A
Q
F
GA
HQ
A
L
fig|444447.5.peg.343
Escherichia coli O157:H7 str. EC4206 (22-482/488)
QL
Q
SRIVHFG
F
GAFHRAHQAL
L
TD
R
V
L
N
A
QG
G
DWGICE
I
S
L
FS
G
D
Q
--
L
MSQ
L
RA
Q
NH
LYTV
L
-----
EKGA
DG
N
Q
A
I
I
V
G
A
V
H
E
--
C
L
N
A
K
L
D
SLAA
I
I
EKFCE
PQ
V
AIVSLT
I
TEKGYC
I
D
P
A
T
G
A
LD
T
S
NP
R
I
I
HDL
Q
T
P
EE
P
H
SA
P
G
I
LVEAL
KR
RRE
R
GL
T
P
FTV
L
SCDNI
PD
NGHV
V
K
N
AVLG
M
A
E
K
R
S
-
PE
-
LA
G
WI
K
E
H
VSFP
G
TMVDRIVPAAT
D
E
S
LAEI
S
Q
H
LGV
N
DPCAI
S
CEPF
I
QWV
V
E
-----------
DNFV
A
GRP
A
W
EVA
GVQ
M
V
N
DV
L
P
W
EEMKLRMLNGSHSFLAYLGYL
S
G
FA
H
I
S
D
C
M
Q
D
RAF
R
H
AA
RT
LM
L
D
EQAPTL
R
I
K
D
-
V
DL
TQ
YA
DK
LI
A
RF
A
NP
A
LKH
K
TWQIAMDGSQK
-----
LPQR
M
LAG
I
R
I
HL
G
RE
T
D
W
SL
LALGVAGWMRY
VS
GVD
DA
GNAIDV
R
DP
L
--
S
D
K
I
R
D
L
V
A
G
SI
-----
SE
Q
RV
T
ALL
S
L
REV
F
G
DDLP
D
NP
H
FV
Q
A
I
EQ
A
R
QQI
A
Q
F
GA
HQ
A
L
fig|478004.5.peg.5388
Escherichia coli O157:H7 str. EC4401 (22-482/488)
QL
Q
SRIVHFG
F
GAFHRAHQAL
L
TD
R
V
L
N
A
QG
G
DWGICE
I
S
L
FS
G
D
Q
--
L
MSQ
L
RA
Q
NH
LYTV
L
-----
EKGA
DG
N
Q
A
I
I
V
G
A
V
H
E
--
C
L
N
A
K
L
D
SLAA
I
I
EKFCE
PQ
V
AIVSLT
I
TEKGYC
I
D
P
A
T
G
A
LD
T
S
NP
R
I
I
HDL
Q
T
P
EE
P
H
SA
P
G
I
LVEAL
KR
RRE
R
GL
T
P
FTV
L
SCDNI
PD
NGHV
V
K
N
AVLG
M
A
E
K
R
S
-
PE
-
LA
G
WI
K
E
H
VSFP
G
TMVDRIVPAAT
D
E
S
LAEI
S
Q
H
LGV
N
DPCAI
S
CEPF
I
QWV
V
E
-----------
DNFV
A
GRP
A
W
EVA
GVQ
M
V
N
DV
L
P
W
EEMKLRMLNGSHSFLAYLGYL
S
G
FA
H
I
S
D
C
M
Q
D
RAF
R
H
AA
RT
LM
L
D
EQAPTL
R
I
K
D
-
V
DL
TQ
YA
DK
LI
A
RF
A
NP
A
LKH
K
TWQIAMDGSQK
-----
LPQR
M
LAG
I
R
I
HL
G
RE
T
D
W
SL
LALGVAGWMRY
VS
GVD
DA
GNAIDV
R
DP
L
--
S
D
K
I
R
D
L
V
A
G
SI
-----
SE
Q
RV
T
ALL
S
L
REV
F
G
DDLP
D
NP
H
FV
Q
A
I
EQ
A
R
QQI
A
Q
F
GA
HQ
A
L
fig|478006.5.peg.4201
Escherichia coli O157:H7 str. EC4501 (22-482/488)
QL
Q
SRIVHFG
F
GAFHRAHQAL
L
TD
R
V
L
N
A
QG
G
DWGICE
I
S
L
FS
G
D
Q
--
L
MSQ
L
RA
Q
NH
LYTV
L
-----
EKGA
DG
N
Q
A
I
I
V
G
A
V
H
E
--
C
L
N
A
K
L
D
SLAA
I
I
EKFCE
PQ
V
AIVSLT
I
TEKGYC
I
D
P
A
T
G
A
LD
T
S
NP
R
I
I
HDL
Q
T
P
EE
P
H
SA
P
G
I
LVEAL
KR
RRE
R
GL
T
P
FTV
L
SCDNI
PD
NGHV
V
K
N
AVLG
M
A
E
K
R
S
-
PE
-
LA
G
WI
K
E
H
VSFP
G
TMVDRIVPAAT
D
E
S
LAEI
S
Q
H
LGV
N
DPCAI
S
CEPF
I
QWV
V
E
-----------
DNFV
A
GRP
A
W
EVA
GVQ
M
V
N
DV
L
P
W
EEMKLRMLNGSHSFLAYLGYL
S
G
FA
H
I
S
D
C
M
Q
D
RAF
R
H
AA
RT
LM
L
D
EQAPTL
R
I
K
D
-
V
DL
TQ
YA
DK
LI
A
RF
A
NP
A
LKH
K
TWQIAMDGSQK
-----
LPQR
M
LAG
I
R
I
HL
G
RE
T
D
W
SL
LALGVAGWMRY
VS
GVD
DA
GNAIDV
R
DP
L
--
S
D
K
I
R
D
L
V
A
G
SI
-----
SE
Q
RV
T
ALL
S
L
REV
F
G
DDLP
D
NP
H
FV
Q
A
I
EQ
A
R
QQI
A
Q
F
GA
HQ
A
L
fig|478007.5.peg.5187
Escherichia coli O157:H7 str. EC508 (22-482/488)
QL
Q
SRIVHFG
F
GAFHRAHQAL
L
TD
R
V
L
N
A
QG
G
DWGICE
I
S
L
FS
G
D
Q
--
L
MSQ
L
RA
Q
NH
LYTV
L
-----
EKGA
DG
N
Q
A
I
I
V
G
A
V
H
E
--
C
L
N
A
K
L
D
SLAA
I
I
EKFCE
PQ
V
AIVSLT
I
TEKGYC
I
D
P
A
T
G
A
LD
T
S
NP
R
I
I
HDL
Q
T
P
EE
P
H
SA
P
G
I
LVEAL
KR
RRE
R
GL
T
P
FTV
L
SCDNI
PD
NGHV
V
K
N
AVLG
M
A
E
K
R
S
-
PE
-
LA
G
WI
K
E
H
VSFP
G
TMVDRIVPAAT
D
E
S
LAEI
S
Q
H
LGV
N
DPCAI
S
CEPF
I
QWV
V
E
-----------
DNFV
A
GRP
A
W
EVA
GVQ
M
V
N
DV
L
P
W
EEMKLRMLNGSHSFLAYLGYL
S
G
FA
H
I
S
D
C
M
Q
D
RAF
R
H
AA
RT
LM
L
D
EQAPTL
R
I
K
D
-
V
DL
TQ
YA
DK
LI
A
RF
A
NP
A
LKH
K
TWQIAMDGSQK
-----
LPQR
M
LAG
I
R
I
HL
G
RE
T
D
W
SL
LALGVAGWMRY
VS
GVD
DA
GNAIDV
R
DP
L
--
S
D
K
I
R
D
L
V
A
G
SI
-----
SE
Q
RV
T
ALL
S
L
REV
F
G
DDLP
D
NP
H
FV
Q
A
I
EQ
A
R
QQI
A
Q
F
GA
HQ
A
L
fig|478008.5.peg.4104
Escherichia coli O157:H7 str. EC869 (22-482/488)
QL
Q
SRIVHFG
F
GAFHRAHQAL
L
TD
R
V
L
N
A
QG
G
DWGICE
I
S
L
FS
G
D
Q
--
L
MSQ
L
RA
Q
NH
LYTV
L
-----
EKGA
DG
N
Q
A
I
I
V
G
A
V
H
E
--
C
L
N
A
K
L
D
SLAA
I
I
EKFCE
PQ
V
AIVSLT
I
TEKGYC
I
D
P
A
T
G
A
LD
T
S
NP
R
I
I
HDL
Q
T
P
EE
P
H
SA
P
G
I
LVEAL
KR
RRE
R
GL
T
P
FTV
L
SCDNI
PD
NGHV
V
K
N
AVLG
M
A
E
K
R
S
-
PE
-
LA
G
WI
K
E
H
VSFP
G
TMVDRIVPAAT
D
E
S
LAEI
S
Q
H
LGV
N
DPCAI
S
CEPF
I
QWV
V
E
-----------
DNFV
A
GRP
A
W
EVA
GVQ
M
V
N
DV
L
P
W
EEMKLRMLNGSHSFLAYLGYL
S
G
FA
H
I
S
D
C
M
Q
D
RAF
R
H
AA
RT
LM
L
D
EQAPTL
R
I
K
D
-
V
DL
TQ
YA
DK
LI
A
RF
A
NP
A
LKH
K
TWQIAMDGSQK
-----
LPQR
M
LAG
I
R
I
HL
G
RE
T
D
W
SL
LALGVAGWMRY
VS
GVD
DA
GNAIDV
R
DP
L
--
S
D
K
I
R
D
L
V
A
G
SI
-----
SE
Q
RV
T
ALL
S
L
REV
F
G
DDLP
D
NP
H
FV
Q
A
I
EQ
A
R
QQI
A
Q
F
GA
HQ
A
L
fig|637388.3.peg.409
Escherichia coli O157:H7 str. FRIK2000 (22-482/488)
QL
Q
SRIVHFG
F
GAFHRAHQAL
L
TD
R
V
L
N
A
QG
G
DWGICE
I
S
L
FS
G
D
Q
--
L
MSQ
L
RA
Q
NH
LYTV
L
-----
EKGA
DG
N
Q
A
I
I
V
G
A
V
H
E
--
C
L
N
A
K
L
D
SLAA
I
I
EKFCE
PQ
V
AIVSLT
I
TEKGYC
I
D
P
A
T
G
A
LD
T
S
NP
R
I
I
HDL
Q
T
P
EE
P
H
SA
P
G
I
LVEAL
KR
RRE
R
GL
T
P
FTV
L
SCDNI
PD
NGHV
V
K
N
AVLG
M
A
E
K
R
S
-
PE
-
LA
G
WI
K
E
H
VSFP
G
TMVDRIVPAAT
D
E
S
LAEI
S
Q
H
LGV
N
DPCAI
S
CEPF
I
QWV
V
E
-----------
DNFV
A
GRP
A
W
EVA
GVQ
M
V
N
DV
L
P
W
EEMKLRMLNGSHSFLAYLGYL
S
G
FA
H
I
S
D
C
M
Q
D
RAF
R
H
AA
RT
LM
L
D
EQAPTL
R
I
K
D
-
V
DL
TQ
YA
DK
LI
A
RF
A
NP
A
LKH
K
TWQIAMDGSQK
-----
LPQR
M
LAG
I
R
I
HL
G
RE
T
D
W
SL
LALGVAGWMRY
VS
GVD
DA
GNAIDV
R
DP
L
--
S
D
K
I
R
D
L
V
A
G
SI
-----
SE
Q
RV
T
ALL
S
L
REV
F
G
DDLP
D
NP
H
FV
Q
A
I
EQ
A
R
QQI
A
Q
F
GA
HQ
A
L
fig|570506.3.peg.4923
Escherichia coli O157:H7 str. FRIK966 (22-482/488)
QL
Q
SRIVHFG
F
GAFHRAHQAL
L
TD
R
V
L
N
A
QG
G
DWGICE
I
S
L
FS
G
D
Q
--
L
MSQ
L
RA
Q
NH
LYTV
L
-----
EKGA
DG
N
Q
A
I
I
V
G
A
V
H
E
--
C
L
N
A
K
L
D
SLAA
I
I
EKFCE
PQ
V
AIVSLT
I
TEKGYC
I
D
P
A
T
G
A
LD
T
S
NP
R
I
I
HDL
Q
T
P
EE
P
H
SA
P
G
I
LVEAL
KR
RRE
R
GL
T
P
FTV
L
SCDNI
PD
NGHV
V
K
N
AVLG
M
A
E
K
R
S
-
PE
-
LA
G
WI
K
E
H
VSFP
G
TMVDRIVPAAT
D
E
S
LAEI
S
Q
H
LGV
N
DPCAI
S
CEPF
I
QWV
V
E
-----------
DNFV
A
GRP
A
W
EVA
GVQ
M
V
N
DV
L
P
W
EEMKLRMLNGSHSFLAYLGYL
S
G
FA
H
I
S
D
C
M
Q
D
RAF
R
H
AA
RT
LM
L
D
EQAPTL
R
I
K
D
-
V
DL
TQ
YA
DK
LI
A
RF
A
NP
A
LKH
K
TWQIAMDGSQK
-----
LPQR
M
LAG
I
R
I
HL
G
RE
T
D
W
SL
LALGVAGWMRY
VS
GVD
DA
GNAIDV
R
DP
L
--
S
D
K
I
R
D
L
V
A
G
SI
-----
SE
Q
RV
T
ALL
S
L
REV
F
G
DDLP
D
NP
H
FV
Q
A
I
EQ
A
R
QQI
A
Q
F
GA
HQ
A
L
fig|386585.9.peg.3196
Escherichia coli O157:H7 str. Sakai (22-482/488)
QL
Q
SRIVHFG
F
GAFHRAHQAL
L
TD
R
V
L
N
A
QG
G
DWGICE
I
S
L
FS
G
D
Q
--
L
MSQ
L
RA
Q
NH
LYTV
L
-----
EKGA
DG
N
Q
A
I
I
V
G
A
V
H
E
--
C
L
N
A
K
L
D
SLAA
I
I
EKFCE
PQ
V
AIVSLT
I
TEKGYC
I
D
P
A
T
G
A
LD
T
S
NP
R
I
I
HDL
Q
T
P
EE
P
H
SA
P
G
I
LVEAL
KR
RRE
R
GL
T
P
FTV
L
SCDNI
PD
NGHV
V
K
N
AVLG
M
A
E
K
R
S
-
PE
-
LA
G
WI
K
E
H
VSFP
G
TMVDRIVPAAT
D
E
S
LAEI
S
Q
H
LGV
N
DPCAI
S
CEPF
I
QWV
V
E
-----------
DNFV
A
GRP
A
W
EVA
GVQ
M
V
N
DV
L
P
W
EEMKLRMLNGSHSFLAYLGYL
S
G
FA
H
I
S
D
C
M
Q
D
RAF
R
H
AA
RT
LM
L
D
EQAPTL
R
I
K
D
-
V
DL
TQ
YA
DK
LI
A
RF
A
NP
A
LKH
K
TWQIAMDGSQK
-----
LPQR
M
LAG
I
R
I
HL
G
RE
T
D
W
SL
LALGVAGWMRY
VS
GVD
DA
GNAIDV
R
DP
L
--
S
D
K
I
R
D
L
V
A
G
SI
-----
SE
Q
RV
T
ALL
S
L
REV
F
G
DDLP
D
NP
H
FV
Q
A
I
EQ
A
R
QQI
A
Q
F
GA
HQ
A
L
fig|544404.4.peg.3104
Escherichia coli O157:H7 str. TW14359 (22-482/488)
QL
Q
SRIVHFG
F
GAFHRAHQAL
L
TD
R
V
L
N
A
QG
G
DWGICE
I
S
L
FS
G
D
Q
--
L
MSQ
L
RA
Q
NH
LYTV
L
-----
EKGA
DG
N
Q
A
I
I
V
G
A
V
H
E
--
C
L
N
A
K
L
D
SLAA
I
I
EKFCE
PQ
V
AIVSLT
I
TEKGYC
I
D
P
A
T
G
A
LD
T
S
NP
R
I
I
HDL
Q
T
P
EE
P
H
SA
P
G
I
LVEAL
KR
RRE
R
GL
T
P
FTV
L
SCDNI
PD
NGHV
V
K
N
AVLG
M
A
E
K
R
S
-
PE
-
LA
G
WI
K
E
H
VSFP
G
TMVDRIVPAAT
D
E
S
LAEI
S
Q
H
LGV
N
DPCAI
S
CEPF
I
QWV
V
E
-----------
DNFV
A
GRP
A
W
EVA
GVQ
M
V
N
DV
L
P
W
EEMKLRMLNGSHSFLAYLGYL
S
G
FA
H
I
S
D
C
M
Q
D
RAF
R
H
AA
RT
LM
L
D
EQAPTL
R
I
K
D
-
V
DL
TQ
YA
DK
LI
A
RF
A
NP
A
LKH
K
TWQIAMDGSQK
-----
LPQR
M
LAG
I
R
I
HL
G
RE
T
D
W
SL
LALGVAGWMRY
VS
GVD
DA
GNAIDV
R
DP
L
--
S
D
K
I
R
D
L
V
A
G
SI
-----
SE
Q
RV
T
ALL
S
L
REV
F
G
DDLP
D
NP
H
FV
Q
A
I
EQ
A
R
QQI
A
Q
F
GA
HQ
A
L
fig|502346.5.peg.4319
Escherichia coli O157:H7 str. TW14588 (22-482/488)
QL
Q
SRIVHFG
F
GAFHRAHQAL
L
TD
R
V
L
N
A
QG
G
DWGICE
I
S
L
FS
G
D
Q
--
L
MSQ
L
RA
Q
NH
LYTV
L
-----
EKGA
DG
N
Q
A
I
I
V
G
A
V
H
E
--
C
L
N
A
K
L
D
SLAA
I
I
EKFCE
PQ
V
AIVSLT
I
TEKGYC
I
D
P
A
T
G
A
LD
T
S
NP
R
I
I
HDL
Q
T
P
EE
P
H
SA
P
G
I
LVEAL
KR
RRE
R
GL
T
P
FTV
L
SCDNI
PD
NGHV
V
K
N
AVLG
M
A
E
K
R
S
-
PE
-
LA
G
WI
K
E
H
VSFP
G
TMVDRIVPAAT
D
E
S
LAEI
S
Q
H
LGV
N
DPCAI
S
CEPF
I
QWV
V
E
-----------
DNFV
A
GRP
A
W
EVA
GVQ
M
V
N
DV
L
P
W
EEMKLRMLNGSHSFLAYLGYL
S
G
FA
H
I
S
D
C
M
Q
D
RAF
R
H
AA
RT
LM
L
D
EQAPTL
R
I
K
D
-
V
DL
TQ
YA
DK
LI
A
RF
A
NP
A
LKH
K
TWQIAMDGSQK
-----
LPQR
M
LAG
I
R
I
HL
G
RE
T
D
W
SL
LALGVAGWMRY
VS
GVD
DA
GNAIDV
R
DP
L
--
S
D
K
I
R
D
L
V
A
G
SI
-----
SE
Q
RV
T
ALL
S
L
REV
F
G
DDLP
D
NP
H
FV
Q
A
I
EQ
A
R
QQI
A
Q
F
GA
HQ
A
L
fig|749531.3.peg.1969
Escherichia coli MS 69-1 (22-482/488)
QL
Q
SRIVHFG
F
GAFHRAHQAL
L
TD
R
V
L
N
A
QG
G
DWGICE
I
S
L
FS
G
D
Q
--
L
MSQ
L
RA
Q
NH
LYTV
L
-----
EKGA
DG
N
Q
A
I
I
V
G
A
V
H
E
--
C
L
N
A
K
L
D
SLAA
I
I
EKFCE
PQ
V
AIVSLT
I
TEKGYC
I
D
P
A
T
G
A
LD
T
S
NP
R
I
I
HDL
Q
NP
EE
P
H
SA
P
G
I
LVEAL
KR
RRE
R
GL
A
P
FTV
L
SCDNI
PD
NGHV
V
K
N
AVLG
M
A
E
K
R
S
-
PE
-
LA
G
WI
K
E
H
VSFP
G
TMVDRIVPAAT
D
E
S
LAEI
S
Q
H
LGV
N
DPCAI
S
CEPF
I
QWV
V
E
-----------
DNFV
A
GRP
A
W
EVA
GVQ
M
V
N
DV
L
P
W
EEMKLRMLNGSHSFLAYLGYL
S
G
FA
H
I
S
D
C
M
Q
D
RAF
R
H
AA
RT
LM
L
D
EQAPTL
R
I
K
D
-
V
DL
TQ
YA
DK
LI
A
RF
A
NP
A
LKH
K
TWQIAMDGSQK
-----
LPQR
M
LAG
I
R
I
HL
A
RE
T
D
W
SL
LALGVAGWMRY
VS
GVD
DA
GNAID
D
R
DP
L
--
S
D
K
I
R
E
L
V
A
G
SS
-----
SE
Q
RV
T
ALL
S
L
REV
F
G
DDLP
D
NP
H
FV
Q
A
I
EQ
A
W
QQI
A
Q
F
GA
HQ
A
L
fig|431946.3.peg.2148
Escherichia coli SE15 (22-482/488)
QL
Q
SRIVHFG
F
GAFHRAHQAL
L
TD
R
V
L
N
A
QG
G
DWGICE
I
S
L
FS
G
D
Q
--
L
MSQ
L
RA
Q
NH
LYTV
L
-----
EKGA
DG
N
Q
A
I
I
V
G
A
V
H
E
--
C
L
N
A
K
L
D
SLAA
I
I
EKFCE
PQ
V
AIVSLT
I
TEKGYC
I
D
P
A
T
G
A
LD
T
S
NP
R
I
I
HDL
Q
NP
EE
P
H
SA
P
G
I
LVEAL
KR
RRE
R
G
H
T
P
FTV
L
SCDNI
PD
NGHV
V
K
N
AVLG
M
A
E
K
R
S
-
PE
-
LA
G
WI
K
E
H
VSFP
G
TMVDRIVPAAT
N
E
S
LAEI
S
Q
H
LGV
N
DPCAI
S
CEPF
I
QWV
V
E
-----------
DNFV
A
GRP
A
W
EVA
GVQ
M
V
N
DV
L
P
W
EEMKLRMLNGSHSFLAYLGYL
S
G
FA
H
I
S
D
C
M
Q
D
RAF
R
H
AA
RT
LM
L
D
EQAPTL
R
I
K
D
-
V
DL
TQ
YA
DK
LI
A
RF
A
NP
A
LKH
K
TWQIAMDGSQK
-----
LPQR
M
LAG
I
R
I
HL
G
RE
T
D
W
SL
LALGVAGWMRY
VS
GVD
DA
GNAIDV
R
DP
L
--
S
D
K
I
R
E
L
V
A
G
SS
-----
SE
Q
RV
T
ALL
S
L
REI
F
G
DDLP
D
NP
H
FV
Q
V
I
EQ
A
W
QQI
A
Q
F
GA
HQ
A
L
fig|216593.1.peg.2573
Escherichia coli E2348/69 (25-485/491)
QL
Q
SRIVHFG
F
GAFHRAHQAL
L
TD
R
V
L
N
A
QG
G
DWGICE
I
S
L
FS
G
D
Q
--
L
MSQ
L
RA
Q
NH
LYTV
L
-----
EKGA
DG
N
Q
A
I
I
V
G
A
V
H
E
--
C
L
N
A
K
L
D
SLAA
I
I
EKFCE
PQ
V
AIVSLT
I
TEKGYC
I
D
P
A
T
G
A
LD
T
S
NP
R
I
I
HDL
Q
NP
EE
P
H
SA
P
G
I
LVEAL
KR
RRE
R
GL
T
P
FTV
L
SCDNI
PD
NGHV
V
K
N
AVLG
M
A
E
K
R
S
-
PE
-
LA
G
WI
K
E
H
VSFP
G
TMVDRIVPAAT
N
E
S
LAEI
S
Q
H
LGV
N
DPCAI
S
CEPF
I
QWV
V
E
-----------
DNFV
A
GRP
A
W
EVA
GVQ
M
V
N
DV
L
P
W
EEMKLRMLNGSHSFLAYLGYL
S
G
FA
H
I
S
D
C
M
Q
D
RAF
R
H
AA
RT
LM
L
D
EQAPTL
R
I
K
D
-
V
DL
TQ
YA
DK
LI
A
RF
A
NP
A
LKH
K
TWQIAMDGSQK
-----
LPQR
M
LAG
I
R
I
HL
G
RE
T
D
W
SL
LALGVAGWMRY
VS
GVD
DA
GNAIDV
R
DP
L
--
S
D
K
I
R
E
L
V
A
G
SS
-----
SE
Q
RV
T
ALL
S
L
REI
F
G
DDLP
D
NP
H
FV
Q
A
I
EQ
A
W
QQI
A
Q
F
GA
HQ
A
L
fig|749550.3.peg.1763
Escherichia coli MS 200-1 (22-482/488)
QL
Q
SRIVHFG
F
GAFHRAHQAL
L
TD
R
V
L
N
A
QG
G
DWGICE
I
S
L
FS
G
D
Q
--
L
MSQ
L
RA
Q
NH
LYTV
L
-----
EKGA
DG
N
Q
A
I
I
V
G
A
V
H
E
--
C
L
N
A
K
L
D
SLAA
I
I
EKFCE
PQ
V
AIVSLT
I
TEKGYC
I
D
P
A
T
G
A
LD
T
S
NP
R
I
I
HDL
Q
NP
EE
P
H
SA
P
G
I
LVEAL
KR
RRE
R
GL
T
P
FTV
L
SCDNI
PD
NGHV
V
K
N
AVLG
M
A
E
K
R
S
-
PE
-
LA
G
WI
K
E
H
VSFP
G
TMVDRIVPAAT
N
E
S
LAEI
S
Q
H
LGV
N
DPCAI
S
CEPF
I
QWV
V
E
-----------
DNFV
A
GRP
A
W
EVA
GVQ
M
V
N
DV
L
P
W
EEMKLRMLNGSHSFLAYLGYL
S
G
FA
H
I
S
D
C
M
Q
D
RAF
R
H
AA
RT
LM
L
D
EQAPTL
R
I
K
D
-
V
DL
TQ
YA
DK
LI
A
RF
A
NP
A
LKH
K
TWQIAMDGSQK
-----
LPQR
M
LA
S
I
R
I
HL
G
RE
T
D
W
SL
LALGVAGWMRY
VS
GVD
DA
GNAIDV
R
DP
L
--
S
D
K
I
R
E
L
V
A
G
SS
-----
SE
Q
RV
T
ALL
S
L
REI
F
G
DDLP
D
NP
H
FV
Q
A
I
EQ
A
W
QQI
A
Q
F
GA
HQ
A
L
fig|574521.7.peg.2372
Escherichia coli O127:H6 str. E2348/69 (22-482/488)
QL
Q
SRIVHFG
F
GAFHRAHQAL
L
TD
R
V
L
N
A
QG
G
DWGICE
I
S
L
FS
G
D
Q
--
L
MSQ
L
RA
Q
NH
LYTV
L
-----
EKGA
DG
N
Q
A
I
I
V
G
A
V
H
E
--
C
L
N
A
K
L
D
SLAA
I
I
EKFCE
PQ
V
AIVSLT
I
TEKGYC
I
D
P
A
T
G
A
LD
T
S
NP
R
I
I
HDL
Q
NP
EE
P
H
SA
P
G
I
LVEAL
KR
RRE
R
GL
T
P
FTV
L
SCDNI
PD
NGHV
V
K
N
AVLG
M
A
E
K
R
S
-
PE
-
LA
G
WI
K
E
H
VSFP
G
TMVDRIVPAAT
N
E
S
LAEI
S
Q
H
LGV
N
DPCAI
S
CEPF
I
QWV
V
E
-----------
DNFV
A
GRP
A
W
EVA
GVQ
M
V
N
DV
L
P
W
EEMKLRMLNGSHSFLAYLGYL
S
G
FA
H
I
S
D
C
M
Q
D
RAF
R
H
AA
RT
LM
L
D
EQAPTL
R
I
K
D
-
V
DL
TQ
YA
DK
LI
A
RF
A
NP
A
LKH
K
TWQIAMDGSQK
-----
LPQR
M
LAG
I
R
I
HL
G
RE
T
D
W
SL
LALGVAGWMRY
VS
GVD
DA
GNAIDV
R
DP
L
--
S
D
K
I
R
E
L
V
A
G
SS
-----
SE
Q
RV
T
ALL
S
L
REI
F
G
DDLP
D
NP
H
FV
Q
A
I
EQ
A
W
QQI
A
Q
F
GA
HQ
A
L
fig|216592.1.peg.2966
Escherichia coli 042 (25-485/491)
QL
Q
SRIVHFG
F
GAFHRAHQAL
L
TD
R
V
L
N
A
QG
G
DWGICE
I
S
L
FS
G
D
Q
--
L
MSQ
L
RA
Q
NH
LYTV
L
-----
EKGA
DG
N
Q
A
I
I
V
G
A
V
H
E
--
C
L
N
A
K
L
D
SLAA
I
I
EKFCE
PQ
V
AIVSLT
I
TEKGYC
I
D
P
A
T
G
A
LD
T
S
N
L
R
I
I
HDL
Q
T
P
EE
P
H
SA
P
G
I
LVEAL
KR
RRE
R
GL
T
P
FTV
L
SCDNI
PD
NGHV
V
K
N
AVLG
M
A
E
K
R
S
-
PE
-
LA
G
WI
K
E
H
VSFP
G
TMVDRIVPAAT
D
E
S
LAEI
S
Q
H
LGV
N
DPCAI
S
CEPF
I
QWV
V
E
-----------
DNFV
A
GRP
A
W
EVA
GVQ
M
V
N
DV
L
P
W
EEMKLRMLNGSHSFLAYLGYL
S
G
FA
H
I
S
D
C
M
Q
D
RAF
R
H
AA
RA
LM
L
D
EQAPTL
R
I
K
D
-
V
DL
TQ
YA
DK
LI
A
RF
A
NP
A
LKH
K
TWQIAMDGSQK
-----
LPQR
M
LAG
I
R
I
HL
G
RE
T
D
W
SM
LALGVAGWMRY
VS
GVD
DA
GNAIDV
R
DP
L
--
S
D
K
I
R
E
L
V
A
G
SS
-----
SE
Q
RV
T
ALL
S
L
REV
F
G
DDLP
D
NP
H
FV
Q
A
I
EQ
A
W
QQI
V
Q
F
GA
HQ
A
L
fig|216592.3.peg.2514
Escherichia coli 042 (22-482/488)
QL
Q
SRIVHFG
F
GAFHRAHQAL
L
TD
R
V
L
N
A
QG
G
DWGICE
I
S
L
FS
G
D
Q
--
L
MSQ
L
RA
Q
NH
LYTV
L
-----
EKGA
DG
N
Q
A
I
I
V
G
A
V
H
E
--
C
L
N
A
K
L
D
SLAA
I
I
EKFCE
PQ
V
AIVSLT
I
TEKGYC
I
D
P
A
T
G
A
LD
T
S
N
L
R
I
I
HDL
Q
T
P
EE
P
H
SA
P
G
I
LVEAL
KR
RRE
R
GL
T
P
FTV
L
SCDNI
PD
NGHV
V
K
N
AVLG
M
A
E
K
R
S
-
PE
-
LA
G
WI
K
E
H
VSFP
G
TMVDRIVPAAT
D
E
S
LAEI
S
Q
H
LGV
N
DPCAI
S
CEPF
I
QWV
V
E
-----------
DNFV
A
GRP
A
W
EVA
GVQ
M
V
N
DV
L
P
W
EEMKLRMLNGSHSFLAYLGYL
S
G
FA
H
I
S
D
C
M
Q
D
RAF
R
H
AA
RA
LM
L
D
EQAPTL
R
I
K
D
-
V
DL
TQ
YA
DK
LI
A
RF
A
NP
A
LKH
K
TWQIAMDGSQK
-----
LPQR
M
LAG
I
R
I
HL
G
RE
T
D
W
SM
LALGVAGWMRY
VS
GVD
DA
GNAIDV
R
DP
L
--
S
D
K
I
R
E
L
V
A
G
SS
-----
SE
Q
RV
T
ALL
S
L
REV
F
G
DDLP
D
NP
H
FV
Q
A
I
EQ
A
W
QQI
V
Q
F
GA
HQ
A
L
fig|656417.3.peg.2848
Escherichia coli M605 (22-482/488)
QL
Q
SRIVHFG
F
GAFHRAHQAL
L
TD
R
V
L
N
A
QG
G
DWGICE
I
S
L
FS
G
D
Q
--
L
MSQ
L
RA
Q
NH
LYTV
L
-----
EKGA
DG
N
Q
A
I
I
V
G
A
V
H
E
--
C
L
N
A
K
L
D
SLAA
I
I
EKFCE
PQ
V
AIVSLT
I
TEKGYC
I
D
P
A
T
G
A
LD
T
S
NP
R
I
I
HDL
Q
NP
EE
P
H
SA
P
G
I
LVEAL
KR
RRE
R
GL
T
P
FTV
L
SCDNI
PD
NGHV
V
K
N
AVLG
M
A
E
K
R
S
-
PE
-
LA
G
WI
K
E
H
VSFP
G
TMVDRIVPAAT
N
E
S
LAEI
S
Q
H
LGV
N
DPCAI
S
CEPF
I
QWV
V
E
-----------
DNFV
A
GRP
A
W
EVA
GVQ
M
V
N
DV
L
P
W
EEMKLRMLNGSHSFLAYLGYL
S
G
FA
H
I
S
D
C
M
Q
D
RAF
R
H
AA
RT
LM
L
D
EQAPTL
R
I
K
D
-
V
DL
TQ
YA
DK
LI
A
RF
A
NP
A
LKH
K
TWQIAMDGSQK
-----
LPQR
M
LAG
I
R
I
HL
G
RE
T
D
W
SL
LALGVAGWMRY
VS
GVD
DA
GNAIDV
R
DP
L
--
S
D
K
I
R
E
L
V
A
G
SS
-----
SE
Q
RV
T
ALL
S
L
REI
F
G
DDLP
D
NP
H
FV
Q
V
I
EQ
A
W
QQI
A
Q
F
GA
HQ
A
L
fig|656444.3.peg.3166
Escherichia coli TA280 (22-482/488)
QL
Q
SRIVHFG
F
GAFHRAHQAL
L
TD
R
V
L
N
A
QG
S
DWGICE
I
S
L
FS
G
D
Q
--
L
MSQ
L
RA
Q
NH
LYTV
L
-----
EKGA
DG
N
Q
A
I
I
V
G
A
V
H
E
--
C
L
N
A
K
L
D
SLAA
I
I
EKFCE
PQ
V
AIVSLT
I
TEKGYC
I
D
P
A
T
G
A
LD
T
S
NP
R
I
I
HDL
Q
NP
EE
P
H
SA
P
G
I
LVEAL
KR
RRE
R
GL
A
P
FTV
L
SCDNI
PD
NGHV
V
K
N
AVLG
M
A
E
K
R
S
-
PE
-
LA
G
WI
K
E
H
VSFP
G
TMVDRIVPAAT
D
E
S
LAEI
S
Q
H
LGV
N
D
L
CAI
S
CEPF
I
QWV
V
E
-----------
DNFV
A
GRP
A
W
EVA
GVQ
M
V
N
DV
L
P
W
EEMKLRMLNGSHSFLAYLGYL
S
G
FA
H
I
S
D
C
M
Q
D
RAF
R
H
AA
RT
LM
L
D
EQAPTL
R
I
K
D
-
V
DL
TQ
YA
DK
LI
A
RF
A
NP
A
LKH
K
TWQIAMDGSQK
-----
LPQR
M
LAG
I
R
I
HL
G
RE
T
D
W
SL
LALGVAGWMRY
VS
GVD
DA
GNAIDV
R
DP
L
--
S
D
K
I
R
E
L
V
A
G
SS
-----
SE
Q
RV
T
ALL
S
L
REV
F
G
DDLP
D
NP
H
FV
Q
A
I
EQ
A
W
QQI
A
Q
F
GA
HQ
A
L
fig|656419.3.peg.2932
Escherichia coli M718 (22-482/488)
QL
Q
SRIVHFG
F
GAFHRAHQAL
L
TD
R
V
L
N
A
QG
G
DWGICE
I
S
L
FS
G
D
Q
--
L
MSQ
L
RA
Q
NH
LYTV
L
-----
EKGA
DG
N
Q
A
I
I
V
G
A
V
H
E
--
C
L
N
A
K
L
D
SLAA
I
I
EKFCE
PQ
V
AIVSLT
I
TEKGYC
I
D
P
A
T
G
A
LD
T
S
NP
R
I
I
HDL
Q
T
P
EE
P
H
SA
P
G
I
LVEAL
KR
RRE
R
GL
T
P
FTV
L
SCDNI
PD
NGHV
V
K
N
AVLG
M
A
E
K
R
S
-
PE
-
LA
G
WI
K
E
H
VSFP
G
TMVDRIVPAAT
D
E
S
LAEI
S
Q
H
LGV
N
DPCAI
S
CEPF
I
QWV
V
E
-----------
DNFV
A
GRP
A
W
EVA
GVQ
M
V
N
DV
L
P
W
EEMKLRMLNGSHSFLAYLGYL
S
G
FA
H
I
S
D
C
M
Q
D
RAF
R
H
AA
RT
LM
L
D
EQAPTL
R
I
K
D
-
V
DL
TQ
Y
S
DK
LI
A
RF
A
NP
A
LKH
K
TWQIAMDGSQK
-----
LPQR
M
LAG
I
R
I
HL
G
RE
T
D
W
SL
LALGVAGWMRY
VS
GVD
DA
GNAIDV
R
DP
L
--
S
D
K
I
R
E
L
V
A
G
SS
-----
SE
Q
RV
T
ALL
S
L
REV
F
G
DDLP
D
NP
H
FV
Q
A
I
EQ
A
W
QQI
V
Q
F
GA
HQ
A
L
fig|550677.3.peg.1721
Escherichia coli B354 (22-482/488)
QL
Q
SRIVHFG
F
GAFHRAHQAL
L
TD
R
V
L
N
A
QG
G
DWGICE
I
S
L
FS
G
D
Q
--
L
MSQ
L
RA
Q
NH
LYTV
L
-----
EKGA
DG
N
Q
A
I
I
V
G
A
V
H
E
--
C
L
N
A
K
L
D
SLAA
I
I
EKFCE
PQ
V
AIVSLT
I
TEKGYC
I
D
P
A
T
G
A
LD
T
S
NP
R
I
I
HDL
Q
NP
EE
P
H
SA
P
G
I
LVEAL
KR
RRE
R
GL
T
P
FTV
L
SCDNI
PD
NGHV
V
K
N
AVLG
M
A
E
K
R
S
-
PE
-
LA
G
WI
K
E
H
VSFP
G
TMVDRIVPAAT
D
E
S
LAEI
S
Q
H
LGV
N
DPCAI
S
CEPF
I
QWV
V
E
-----------
DNFV
A
GRP
V
W
EVA
GVQ
M
V
N
DV
L
P
W
EEMKLRMLNGSHSFLAYLGYL
S
G
FA
H
I
S
D
C
M
Q
D
RAF
R
H
AA
RA
LM
L
D
EQAPTL
R
I
K
D
-
V
DL
TQ
YA
DK
LI
A
RF
A
NP
A
LKH
K
TWQIAMDGSQK
-----
LPQR
M
LAG
I
R
I
HL
G
RE
T
D
W
SL
LALGVAGWMRY
VS
GVD
DA
GNAIDV
R
DP
L
--
S
D
K
I
R
E
L
V
A
G
SS
-----
SE
Q
RV
T
ALL
S
L
REV
F
G
DDLP
D
NP
H
FV
Q
A
I
EQ
A
W
QQI
A
Q
F
GA
HQ
A
L
fig|656379.3.peg.2708
Escherichia coli FVEC1302 (22-482/488)
QL
Q
SRIVHFG
F
GAFHRAHQAL
L
TD
R
V
L
N
A
QG
G
DWGICE
I
S
L
FS
G
D
Q
--
L
MSQ
L
RA
Q
NH
LYTV
L
-----
EKGA
DG
N
Q
A
I
I
V
G
A
V
H
E
--
C
L
N
A
K
L
D
SLAA
I
I
EKFCE
PQ
V
AIVSLT
I
TEKGYC
I
D
P
A
T
G
A
LD
T
S
NP
R
I
I
HDL
Q
NP
EE
P
H
SA
P
G
I
LVEAL
KR
RRE
R
GL
A
P
FTV
L
SCDNI
PD
NGHV
V
K
N
AVLG
M
A
E
K
R
S
-
PE
-
LA
G
WI
K
E
H
VSFP
G
TMVDRIVPAAT
D
E
S
LAEI
S
Q
H
LGV
N
DPCAI
S
CEPF
I
QWV
V
E
-----------
DNFV
A
GRP
A
W
EVA
GVQ
M
V
N
DV
L
P
W
EEMKLRMLNGSHSFLAYLGYL
S
G
FA
H
I
S
D
C
M
Q
D
RAF
R
H
A
S
RT
LM
L
D
EQAPTL
R
I
K
D
-
V
DL
TQ
YA
DK
LI
A
RF
A
NP
A
LKH
K
TWQIAMDGSQK
-----
LPQR
M
LAG
I
R
I
HL
G
RE
T
D
W
SL
LALGVAGWMRY
VS
GVD
DA
GNAIDV
R
DP
L
--
S
D
K
I
R
E
L
V
A
G
SS
-----
SE
Q
RV
T
ALL
S
L
REV
F
G
DDLP
D
NP
H
FV
Q
A
I
EQ
A
W
QQI
A
Q
F
GA
HQ
A
L
fig|656380.3.peg.2267
Escherichia coli FVEC1412 (22-482/488)
QL
Q
SRIVHFG
F
GAFHRAHQAL
L
TD
R
V
L
N
A
QG
G
DWGICE
I
S
L
FS
G
D
Q
--
L
MSQ
L
RA
Q
NH
LYTV
L
-----
EKGA
DG
N
Q
A
I
I
V
G
A
V
H
E
--
C
L
N
A
K
L
D
SLAA
I
I
EKFCE
PQ
V
AIVSLT
I
TEKGYC
I
D
P
A
T
G
A
LD
T
S
NP
R
I
I
HDL
Q
NP
EE
P
H
SA
P
G
I
LVEAL
KR
RRE
R
GL
A
P
FTV
L
SCDNI
PD
NGHV
V
K
N
AVLG
M
A
E
K
R
S
-
PE
-
LA
G
WI
K
E
H
VSFP
G
TMVDRIVPAAT
D
E
S
LAEI
S
Q
H
LGV
N
DPCAI
S
CEPF
I
QWV
V
E
-----------
DNFV
A
GRP
A
W
EVA
GVQ
M
V
N
DV
L
P
W
EEMKLRMLNGSHSFLAYLGYL
S
G
FA
H
I
S
D
C
M
Q
D
RAF
R
H
A
S
RT
LM
L
D
EQAPTL
R
I
K
D
-
V
DL
TQ
YA
DK
LI
A
RF
A
NP
A
LKH
K
TWQIAMDGSQK
-----
LPQR
M
LAG
I
R
I
HL
G
RE
T
D
W
SL
LALGVAGWMRY
VS
GVD
DA
GNAIDV
R
DP
L
--
S
D
K
I
R
E
L
V
A
G
SS
-----
SE
Q
RV
T
ALL
S
L
REV
F
G
DDLP
D
NP
H
FV
Q
A
I
EQ
A
W
QQI
A
Q
F
GA
HQ
A
L
fig|749549.3.peg.1854
Escherichia coli MS 198-1 (22-482/488)
QL
Q
SRIVHFG
F
GAFHRAHQAL
L
TD
R
V
L
N
A
QG
G
DWGICE
I
S
L
FS
G
D
Q
--
L
MSQ
L
RA
Q
NH
LYTV
L
-----
EKGA
DG
N
Q
A
I
I
V
G
A
V
H
E
--
C
L
N
A
K
L
D
SLAA
I
I
EKFCE
PQ
V
AIVSLT
I
TEKGYC
I
D
P
A
T
G
A
LD
T
S
NP
R
I
I
HDL
Q
NP
EE
P
H
SA
P
G
I
LVEAL
KR
RRE
R
GL
A
P
FTV
L
SCDNI
PD
NGHV
V
K
N
AVLG
M
A
E
K
R
S
-
PE
-
LA
G
WI
K
E
H
VSFP
G
TMVDRIVPAAT
D
E
S
LAEI
S
Q
H
LGV
N
DPCAI
S
CEPF
I
QWV
V
E
-----------
DNFV
A
GRP
A
W
EVA
GVQ
M
V
N
DV
L
P
W
EEMKLRMLNGSHSFLAYLGYL
S
G
FA
H
I
S
D
C
M
Q
D
RAF
R
H
A
S
RT
LM
L
D
EQAPTL
R
I
K
D
-
V
DL
TQ
YA
DK
LI
A
RF
A
NP
A
LKH
K
TWQIAMDGSQK
-----
LPQR
M
LAG
I
R
I
HL
G
RE
T
D
W
SL
LALGVAGWMRY
VS
GVD
DA
GNAIDV
R
DP
L
--
S
D
K
I
R
E
L
V
A
G
SS
-----
SE
Q
RV
T
ALL
S
L
REV
F
G
DDLP
D
NP
H
FV
Q
A
I
EQ
A
W
QQI
A
Q
F
GA
HQ
A
L
fig|656437.3.peg.2444
Escherichia coli TA143 (22-482/488)
QL
Q
SRIVHFG
F
GAFHRAHQAL
L
TD
R
V
L
N
A
QG
G
DWGICE
I
S
L
FS
G
D
Q
--
L
MSQ
L
RA
Q
NH
LYTV
L
-----
EKGA
DG
N
Q
A
I
I
V
G
A
V
H
E
--
C
L
N
A
K
L
D
SLAA
I
I
EKFCE
PQ
V
AIVSLT
I
TEKGYC
I
D
P
A
T
G
A
LD
T
S
NP
R
I
I
HDL
Q
NP
EE
P
H
SA
P
G
I
LVEAL
KR
RRE
R
GL
A
P
FTV
L
SCDNI
PD
NGHV
V
K
N
AVLG
M
A
E
K
R
S
-
PE
-
LA
G
WI
K
E
H
VSFP
G
TMVDRIVPAAT
D
E
S
LAEI
S
Q
H
LGV
N
DPCAI
S
CEPF
I
QWV
V
E
-----------
DNFV
A
GRP
A
W
EVA
GVQ
M
V
N
DV
L
P
W
EEMKLRMLNGSHSFLAYLGYL
S
G
FA
H
I
S
D
C
M
Q
D
RAF
R
H
A
S
RT
LM
L
D
EQAPTL
R
I
K
D
-
V
DL
TQ
YA
DK
LI
A
RF
A
NP
A
LKH
K
TWQIAMDGSQK
-----
LPQR
M
LAG
I
R
I
HL
G
RE
T
D
W
SL
LALGVAGWMRY
VS
GVD
DA
GNAIDV
R
DP
L
--
S
D
K
I
R
E
L
V
A
G
SS
-----
SE
Q
RV
T
ALL
S
L
REV
F
G
DDLP
D
NP
H
FV
Q
A
I
EQ
A
W
QQI
A
Q
F
GA
HQ
A
L
fig|585056.7.peg.2691
Escherichia coli UMN026 (22-482/488)
QL
Q
SRIVHFG
F
GAFHRAHQAL
L
TD
R
V
L
N
A
QG
G
DWGICE
I
S
L
FS
G
D
Q
--
L
MSQ
L
RA
Q
NH
LYTV
L
-----
EKGA
DG
N
Q
A
I
I
V
G
A
V
H
E
--
C
L
N
A
K
L
D
SLAA
I
I
EKFCE
PQ
V
AIVSLT
I
TEKGYC
I
D
P
A
T
G
A
LD
T
S
NP
R
I
I
HDL
Q
NP
EE
P
H
SA
P
G
I
LVEAL
KR
RRE
R
GL
A
P
FTV
L
SCDNI
PD
NGHV
V
K
N
AVLG
M
A
E
K
R
S
-
PE
-
LA
G
WI
K
E
H
VSFP
G
TMVDRIVPAAT
D
E
S
LAEI
S
Q
H
LGV
N
DPCAI
S
CEPF
I
QWV
V
E
-----------
DNFV
A
GRP
A
W
EVA
GVQ
M
V
N
DV
L
P
W
EEMKLRMLNGSHSFLAYLGYL
S
G
FA
H
I
S
D
C
M
Q
D
RAF
R
H
A
S
RT
LM
L
D
EQAPTL
R
I
K
D
-
V
DL
TQ
YA
DK
LI
A
RF
A
NP
A
LKH
K
TWQIAMDGSQK
-----
LPQR
M
LAG
I
R
I
HL
G
RE
T
D
W
SL
LALGVAGWMRY
VS
GVD
DA
GNAIDV
R
DP
L
--
S
D
K
I
R
E
L
V
A
G
SS
-----
SE
Q
RV
T
ALL
S
L
REV
F
G
DDLP
D
NP
H
FV
Q
A
I
EQ
A
W
QQI
A
Q
F
GA
HQ
A
L
fig|525281.3.peg.3979
Escherichia coli 83972 (22-482/488)
QL
Q
SRIVHFG
F
GAFHRAHQAL
L
TD
R
V
L
N
A
QG
G
DWGICE
I
S
L
FS
G
D
Q
--
L
MSQ
L
RA
Q
NH
LYTV
L
-----
EKGA
DG
N
Q
A
I
I
V
G
A
V
H
D
--
C
L
N
A
K
L
D
SLAA
I
I
EKFCE
PQ
V
AIVSLT
I
TEKGYC
I
D
P
A
T
G
A
LD
T
S
NP
R
I
I
HDL
Q
NP
EE
P
H
SA
P
G
I
LVEAL
KR
RRE
R
GL
A
P
FTV
L
SCDNI
PD
NGHV
V
K
N
AVLG
M
A
E
K
R
S
-
PE
-
LA
G
WI
K
E
H
VSFP
G
TMVDRIVPAAT
D
E
S
LAEI
S
Q
H
LGV
N
DPCAI
S
CEPF
I
QWV
V
E
-----------
DNFV
A
GRP
A
W
EVA
GVQ
M
V
N
DV
L
P
W
EEMKLRMLNGSHSFLAYLGYL
S
G
FA
H
I
S
D
C
M
Q
D
RAF
R
H
AA
RT
LM
L
D
EQAPTL
R
I
K
D
-
V
DL
TQ
YA
DK
LI
A
RF
A
NP
A
LKH
K
TWQIAMDGSQK
-----
LPQR
M
LAG
I
R
I
HL
G
RE
T
D
W
SL
LALGVAGWMRY
VS
GVD
DA
GNAIDV
R
DP
L
--
S
D
K
I
R
E
L
V
A
G
SS
-----
SE
Q
RV
T
ALL
S
L
REI
F
G
DDLP
D
NP
H
FV
Q
A
I
EQ
A
W
QQI
A
Q
F
GA
HQ
A
L
fig|655817.3.peg.2622
Escherichia coli ABU 83972 (22-482/488)
QL
Q
SRIVHFG
F
GAFHRAHQAL
L
TD
R
V
L
N
A
QG
G
DWGICE
I
S
L
FS
G
D
Q
--
L
MSQ
L
RA
Q
NH
LYTV
L
-----
EKGA
DG
N
Q
A
I
I
V
G
A
V
H
D
--
C
L
N
A
K
L
D
SLAA
I
I
EKFCE
PQ
V
AIVSLT
I
TEKGYC
I
D
P
A
T
G
A
LD
T
S
NP
R
I
I
HDL
Q
NP
EE
P
H
SA
P
G
I
LVEAL
KR
RRE
R
GL
A
P
FTV
L
SCDNI
PD
NGHV
V
K
N
AVLG
M
A
E
K
R
S
-
PE
-
LA
G
WI
K
E
H
VSFP
G
TMVDRIVPAAT
D
E
S
LAEI
S
Q
H
LGV
N
DPCAI
S
CEPF
I
QWV
V
E
-----------
DNFV
A
GRP
A
W
EVA
GVQ
M
V
N
DV
L
P
W
EEMKLRMLNGSHSFLAYLGYL
S
G
FA
H
I
S
D
C
M
Q
D
RAF
R
H
AA
RT
LM
L
D
EQAPTL
R
I
K
D
-
V
DL
TQ
YA
DK
LI
A
RF
A
NP
A
LKH
K
TWQIAMDGSQK
-----
LPQR
M
LAG
I
R
I
HL
G
RE
T
D
W
SL
LALGVAGWMRY
VS
GVD
DA
GNAIDV
R
DP
L
--
S
D
K
I
R
E
L
V
A
G
SS
-----
SE
Q
RV
T
ALL
S
L
REI
F
G
DDLP
D
NP
H
FV
Q
A
I
EQ
A
W
QQI
A
Q
F
GA
HQ
A
L
fig|199310.1.peg.2638
Escherichia coli CFT073 (25-485/491)
QL
Q
SRIVHFG
F
GAFHRAHQAL
L
TD
R
V
L
N
A
QG
G
DWGICE
I
S
L
FS
G
D
Q
--
L
MSQ
L
RA
Q
NH
LYTV
L
-----
EKGA
DG
N
Q
A
I
I
V
G
A
V
H
D
--
C
L
N
A
K
L
D
SLAA
I
I
EKFCE
PQ
V
AIVSLT
I
TEKGYC
I
D
P
A
T
G
A
LD
T
S
NP
R
I
I
HDL
Q
NP
EE
P
H
SA
P
G
I
LVEAL
KR
RRE
R
GL
A
P
FTV
L
SCDNI
PD
NGHV
V
K
N
AVLG
M
A
E
K
R
S
-
PE
-
LA
G
WI
K
E
H
VSFP
G
TMVDRIVPAAT
D
E
S
LAEI
S
Q
H
LGV
N
DPCAI
S
CEPF
I
QWV
V
E
-----------
DNFV
A
GRP
A
W
EVA
GVQ
M
V
N
DV
L
P
W
EEMKLRMLNGSHSFLAYLGYL
S
G
FA
H
I
S
D
C
M
Q
D
RAF
R
H
AA
RT
LM
L
D
EQAPTL
R
I
K
D
-
V
DL
TQ
YA
DK
LI
A
RF
A
NP
A
LKH
K
TWQIAMDGSQK
-----
LPQR
M
LAG
I
R
I
HL
G
RE
T
D
W
SL
LALGVAGWMRY
VS
GVD
DA
GNAIDV
R
DP
L
--
S
D
K
I
R
E
L
V
A
G
SS
-----
SE
Q
RV
T
ALL
S
L
REI
F
G
DDLP
D
NP
H
FV
Q
A
I
EQ
A
W
QQI
A
Q
F
GA
HQ
A
L
fig|199310.4.peg.2551
Escherichia coli CFT073 (22-482/488)
QL
Q
SRIVHFG
F
GAFHRAHQAL
L
TD
R
V
L
N
A
QG
G
DWGICE
I
S
L
FS
G
D
Q
--
L
MSQ
L
RA
Q
NH
LYTV
L
-----
EKGA
DG
N
Q
A
I
I
V
G
A
V
H
D
--
C
L
N
A
K
L
D
SLAA
I
I
EKFCE
PQ
V
AIVSLT
I
TEKGYC
I
D
P
A
T
G
A
LD
T
S
NP
R
I
I
HDL
Q
NP
EE
P
H
SA
P
G
I
LVEAL
KR
RRE
R
GL
A
P
FTV
L
SCDNI
PD
NGHV
V
K
N
AVLG
M
A
E
K
R
S
-
PE
-
LA
G
WI
K
E
H
VSFP
G
TMVDRIVPAAT
D
E
S
LAEI
S
Q
H
LGV
N
DPCAI
S
CEPF
I
QWV
V
E
-----------
DNFV
A
GRP
A
W
EVA
GVQ
M
V
N
DV
L
P
W
EEMKLRMLNGSHSFLAYLGYL
S
G
FA
H
I
S
D
C
M
Q
D
RAF
R
H
AA
RT
LM
L
D
EQAPTL
R
I
K
D
-
V
DL
TQ
YA
DK
LI
A
RF
A
NP
A
LKH
K
TWQIAMDGSQK
-----
LPQR
M
LAG
I
R
I
HL
G
RE
T
D
W
SL
LALGVAGWMRY
VS
GVD
DA
GNAIDV
R
DP
L
--
S
D
K
I
R
E
L
V
A
G
SS
-----
SE
Q
RV
T
ALL
S
L
REI
F
G
DDLP
D
NP
H
FV
Q
A
I
EQ
A
W
QQI
A
Q
F
GA
HQ
A
L
fig|749546.3.peg.2955
Escherichia coli MS 185-1 (22-482/488)
QL
Q
SRIVHFG
F
GAFHRAHQAL
L
TD
R
V
L
N
A
QG
G
DWGICE
I
S
L
FS
G
D
Q
--
L
MSQ
L
RA
Q
NH
LYTV
L
-----
EKGA
DG
N
Q
A
I
I
V
G
A
V
H
D
--
C
L
N
A
K
L
D
SLAA
I
I
EKFCE
PQ
V
AIVSLT
I
TEKGYC
I
D
P
A
T
G
A
LD
T
S
NP
R
I
I
HDL
Q
NP
EE
P
H
SA
P
G
I
LVEAL
KR
RRE
R
GL
A
P
FTV
L
SCDNI
PD
NGHV
V
K
N
AVLG
M
A
E
K
R
S
-
PE
-
LA
G
WI
K
E
H
VSFP
G
TMVDRIVPAAT
D
E
S
LAEI
S
Q
H
LGV
N
DPCAI
S
CEPF
I
QWV
V
E
-----------
DNFV
A
GRP
A
W
EVA
GVQ
M
V
N
DV
L
P
W
EEMKLRMLNGSHSFLAYLGYL
S
G
FA
H
I
S
D
C
M
Q
D
RAF
R
H
AA
RT
LM
L
D
EQAPTL
R
I
K
D
-
V
DL
TQ
YA
DK
LI
A
RF
A
NP
A
LKH
K
TWQIAMDGSQK
-----
LPQR
M
LAG
I
R
I
HL
G
RE
T
D
W
SL
LALGVAGWMRY
VS
GVD
DA
GNAIDV
R
DP
L
--
S
D
K
I
R
E
L
V
A
G
SS
-----
SE
Q
RV
T
ALL
S
L
REI
F
G
DDLP
D
NP
H
FV
Q
A
I
EQ
A
W
QQI
A
Q
F
GA
HQ
A
L
fig|749528.3.peg.2572
Escherichia coli MS 45-1 (22-482/488)
QL
Q
SRIVHFG
F
GAFHRAHQAL
L
TD
R
V
L
N
A
QG
G
DWGICE
I
S
L
FS
G
D
Q
--
L
MSQ
L
RA
Q
NH
LYTV
L
-----
EKGA
DG
N
Q
A
I
I
V
G
A
V
H
D
--
C
L
N
A
K
L
D
SLAA
I
I
EKFCE
PQ
V
AIVSLT
I
TEKGYC
I
D
P
A
T
G
A
LD
T
S
NP
R
I
I
HDL
Q
NP
EE
P
H
SA
P
G
I
LVEAL
KR
RRE
R
GL
A
P
FTV
L
SCDNI
PD
NGHV
V
K
N
AVLG
M
A
E
K
R
S
-
PE
-
LA
G
WI
K
E
H
VSFP
G
TMVDRIVPAAT
D
E
S
LAEI
S
Q
H
LGV
N
DPCAI
S
CEPF
I
QWV
V
E
-----------
DNFV
A
GRP
A
W
EVA
GVQ
M
V
N
DV
L
P
W
EEMKLRMLNGSHSFLAYLGYL
S
G
FA
H
I
S
D
C
M
Q
D
RAF
R
H
AA
RT
LM
L
D
EQAPTL
R
I
K
D
-
V
DL
TQ
YA
DK
LI
A
RF
A
NP
A
LKH
K
TWQIAMDGSQK
-----
LPQR
M
LAG
I
R
I
HL
G
RE
T
D
W
SL
LALGVAGWMRY
VS
GVD
DA
GNAIDV
R
DP
L
--
S
D
K
I
R
E
L
V
A
G
SS
-----
SE
Q
RV
T
ALL
S
L
REI
F
G
DDLP
D
NP
H
FV
Q
A
I
EQ
A
W
QQI
A
Q
F
GA
HQ
A
L
fig|585397.7.peg.2626
Escherichia coli ED1a (22-482/488)
QL
Q
SRIVHFG
F
GAFHRAHQAL
L
TD
R
V
L
N
A
QG
G
DWGICE
I
S
L
FS
G
D
Q
--
L
MSQ
L
RA
Q
NH
LYTV
L
-----
EKGA
DG
N
Q
A
I
I
V
G
A
V
H
E
--
C
L
N
A
K
L
D
SLAA
I
I
EKFCE
PQ
V
AIVSLT
I
TEKGYC
I
D
P
A
T
G
A
LD
T
S
NP
R
I
I
HDL
Q
NP
EE
P
H
SA
P
G
I
LVEAL
KR
RRE
R
GL
T
P
FTV
L
SCDNI
PD
NGHV
V
K
N
AVLG
M
A
E
K
R
S
-
PE
-
LA
G
WI
K
E
H
VSFP
G
TMVDRIVPAAT
N
E
S
LAEI
S
Q
H
LGV
N
DPCAI
S
CEPF
I
QWV
V
E
-----------
DNFV
A
GRP
A
W
EVA
GVQ
M
V
N
DV
L
P
W
EEMKLRMLNGSHSFLAYLGYL
S
G
FA
H
I
S
D
C
M
Q
D
RAF
R
H
AA
RT
LM
L
D
EQAPTL
R
I
K
D
-
V
DL
TQ
YA
DK
LI
A
RF
A
NP
A
LKH
K
TWQIAMDGSQK
-----
LPQR
M
LAG
I
R
I
HL
G
RE
T
D
W
SL
LALGVAGWMRY
VS
GVD
DA
GNAIDV
R
DP
L
--
S
D
K
I
R
E
L
V
A
V
SS
-----
SE
Q
RV
T
ALL
S
L
REI
F
G
DDLP
D
NP
H
FV
Q
A
I
EQ
A
W
QQI
A
Q
F
GA
HQ
A
L
fig|585397.9.peg.2623
Escherichia coli ED1a (22-482/488)
QL
Q
SRIVHFG
F
GAFHRAHQAL
L
TD
R
V
L
N
A
QG
G
DWGICE
I
S
L
FS
G
D
Q
--
L
MSQ
L
RA
Q
NH
LYTV
L
-----
EKGA
DG
N
Q
A
I
I
V
G
A
V
H
E
--
C
L
N
A
K
L
D
SLAA
I
I
EKFCE
PQ
V
AIVSLT
I
TEKGYC
I
D
P
A
T
G
A
LD
T
S
NP
R
I
I
HDL
Q
NP
EE
P
H
SA
P
G
I
LVEAL
KR
RRE
R
GL
T
P
FTV
L
SCDNI
PD
NGHV
V
K
N
AVLG
M
A
E
K
R
S
-
PE
-
LA
G
WI
K
E
H
VSFP
G
TMVDRIVPAAT
N
E
S
LAEI
S
Q
H
LGV
N
DPCAI
S
CEPF
I
QWV
V
E
-----------
DNFV
A
GRP
A
W
EVA
GVQ
M
V
N
DV
L
P
W
EEMKLRMLNGSHSFLAYLGYL
S
G
FA
H
I
S
D
C
M
Q
D
RAF
R
H
AA
RT
LM
L
D
EQAPTL
R
I
K
D
-
V
DL
TQ
YA
DK
LI
A
RF
A
NP
A
LKH
K
TWQIAMDGSQK
-----
LPQR
M
LAG
I
R
I
HL
G
RE
T
D
W
SL
LALGVAGWMRY
VS
GVD
DA
GNAIDV
R
DP
L
--
S
D
K
I
R
E
L
V
A
V
SS
-----
SE
Q
RV
T
ALL
S
L
REI
F
G
DDLP
D
NP
H
FV
Q
A
I
EQ
A
W
QQI
A
Q
F
GA
HQ
A
L
fig|753642.3.peg.2916
Escherichia coli NC101 (22-482/488)
QL
Q
SRIVHFG
F
GAFHRAHQAL
L
TD
R
V
L
N
A
QG
G
DWGICE
I
S
L
FS
G
D
Q
--
L
MSQ
L
RA
Q
NH
LYTV
L
-----
EKGA
DG
N
Q
A
I
I
V
G
A
V
H
E
--
C
L
N
A
K
L
D
SLAA
I
I
EKFCE
PQ
V
AIVSLT
I
TEKGYC
I
D
P
A
T
G
A
LD
T
S
NP
R
I
I
HDL
Q
NP
EE
P
H
SA
P
G
I
LVEAL
KR
RRE
R
GL
T
P
FTV
L
SCDNI
PD
NGHV
V
K
N
AVLG
M
A
E
K
R
S
-
PE
-
LA
G
WI
K
E
H
VSFP
G
TMVDRIVPAAT
N
E
S
LAEI
S
Q
H
LGV
N
DPCAI
S
CEPF
I
QWV
V
E
-----------
DNFV
A
GRP
A
W
EVA
GVQ
M
V
N
DV
L
P
W
EEMKLRMLNGSHSFLAYLGYL
S
G
FA
H
I
S
D
C
M
Q
D
RAF
R
H
AA
RT
LM
L
D
EQAPTL
R
I
K
D
-
V
DL
TQ
YA
DK
LI
A
RF
A
NP
A
LKH
K
TWQIAMDGSQK
-----
LPQR
M
LAG
I
R
I
HL
G
RE
T
D
W
SL
LALGVAGWMRY
VS
GVD
DA
GNAIDV
R
DP
L
--
S
D
K
I
R
E
L
V
A
V
SS
-----
SE
Q
RV
T
ALL
S
L
REI
F
G
DDLP
D
NP
H
FV
Q
A
I
EQ
A
W
QQI
A
Q
F
GA
HQ
A
L
fig|685038.3.peg.2234
Escherichia coli O83:H1 str. NRG 857C (22-482/488)
QL
Q
SRIVHFG
F
GAFHRAHQAL
L
TD
R
V
L
N
A
QG
G
DWGICE
I
S
L
FS
G
D
Q
--
L
MSQ
L
RA
Q
NH
LYTV
L
-----
EKGA
DG
N
Q
A
I
I
V
G
A
V
H
E
--
C
L
N
A
K
L
D
SLAA
I
I
EKFCE
PQ
V
AIVSLT
I
TEKGYC
I
D
P
A
T
G
A
LD
T
S
NP
R
I
I
HDL
Q
NP
EE
P
H
SA
P
G
I
LVEAL
KR
RRE
R
GL
T
P
FTV
L
SCDNI
PD
NGHV
V
K
N
AVLG
M
A
E
K
R
S
-
PE
-
LA
G
WI
K
E
H
VSFP
G
TMVDRIVPAAT
N
E
S
LAEI
S
Q
H
LGV
N
DPCAI
S
CEPF
I
QWV
V
E
-----------
DNFV
A
GRP
A
W
EVA
GVQ
M
V
N
DV
L
P
W
EEMKLRMLNGSHSFLAYLGYL
S
G
FA
H
I
S
D
C
M
Q
D
RAF
R
H
AA
RT
LM
L
D
EQAPTL
R
I
K
D
-
V
DL
TQ
YA
DK
LI
A
RF
A
NP
A
LKH
K
TWQIAMDGSQK
-----
LPQR
M
LAG
I
R
I
HL
G
RE
T
D
W
SL
LALGVAGWMRY
VS
GVD
DA
GNAIDV
R
DP
L
--
S
D
K
I
R
E
L
V
A
V
SS
-----
SE
Q
RV
T
ALL
S
L
REI
F
G
DDLP
D
NP
H
FV
Q
A
I
EQ
A
W
QQI
A
Q
F
GA
HQ
A
L
fig|340197.3.peg.234
Escherichia coli F11 (22-466/469)
QL
Q
SRIVHFG
F
GAFHRAHQAL
L
TD
R
V
L
N
A
QG
G
DWGICE
I
S
L
FS
G
D
Q
--
L
MSQ
L
RA
Q
NH
LYTV
L
-----
EKGA
DG
N
Q
A
I
I
V
G
A
V
H
E
--
C
L
N
A
K
L
D
SLAA
I
I
EKFCE
PQ
V
AIVSLT
I
TEKGYC
I
D
P
A
T
G
A
LD
T
S
NP
R
I
I
HDL
Q
NP
EE
P
H
SA
P
G
I
LVEAL
KR
RRE
R
GL
T
P
FTV
L
SCDNI
PD
NGHV
V
K
N
AVLG
M
A
E
K
R
S
-
PE
-
LA
G
WI
K
E
H
VSFP
G
TMVDRIVPAAT
N
E
S
LAEI
S
Q
H
LGV
N
DPCAI
S
CEPF
I
QWV
V
E
-----------
DNFV
A
GRP
A
W
EVA
GVQ
M
V
N
DV
L
P
W
EEMKLRMLNGSHSFLAYLGYL
S
G
FA
H
I
S
D
C
M
Q
D
RAF
R
H
AA
RT
LM
L
D
EQAPTL
R
I
K
D
-
V
DL
TQ
YA
DK
LI
A
RF
A
NP
A
LKH
K
TWQIAMDGSQK
-----
LPQR
M
LA
S
I
R
I
HL
G
RE
T
D
W
SL
LALGVAGWMRY
VS
GVD
DA
GNAIDV
R
DP
L
--
S
D
K
I
R
E
L
V
A
G
SS
-----
SE
Q
RV
T
ALL
S
L
REI
F
G
DDLP
D
NP
H
FV
Q
A
I
fig|340197.5.peg.244
Escherichia coli F11 (22-466/469)
QL
Q
SRIVHFG
F
GAFHRAHQAL
L
TD
R
V
L
N
A
QG
G
DWGICE
I
S
L
FS
G
D
Q
--
L
MSQ
L
RA
Q
NH
LYTV
L
-----
EKGA
DG
N
Q
A
I
I
V
G
A
V
H
E
--
C
L
N
A
K
L
D
SLAA
I
I
EKFCE
PQ
V
AIVSLT
I
TEKGYC
I
D
P
A
T
G
A
LD
T
S
NP
R
I
I
HDL
Q
NP
EE
P
H
SA
P
G
I
LVEAL
KR
RRE
R
GL
T
P
FTV
L
SCDNI
PD
NGHV
V
K
N
AVLG
M
A
E
K
R
S
-
PE
-
LA
G
WI
K
E
H
VSFP
G
TMVDRIVPAAT
N
E
S
LAEI
S
Q
H
LGV
N
DPCAI
S
CEPF
I
QWV
V
E
-----------
DNFV
A
GRP
A
W
EVA
GVQ
M
V
N
DV
L
P
W
EEMKLRMLNGSHSFLAYLGYL
S
G
FA
H
I
S
D
C
M
Q
D
RAF
R
H
AA
RT
LM
L
D
EQAPTL
R
I
K
D
-
V
DL
TQ
YA
DK
LI
A
RF
A
NP
A
LKH
K
TWQIAMDGSQK
-----
LPQR
M
LA
S
I
R
I
HL
G
RE
T
D
W
SL
LALGVAGWMRY
VS
GVD
DA
GNAIDV
R
DP
L
--
S
D
K
I
R
E
L
V
A
G
SS
-----
SE
Q
RV
T
ALL
S
L
REI
F
G
DDLP
D
NP
H
FV
Q
A
I
fig|405955.13.peg.2394
Escherichia coli APEC O1 (22-482/488)
QL
Q
SRIVHFG
F
GAFHRAHQAL
L
TD
R
V
L
N
A
QG
G
DWGICE
I
S
L
FS
G
D
Q
--
L
MSQ
L
RA
Q
NH
LYTV
L
-----
EKGA
DG
N
Q
A
I
I
V
G
A
V
H
E
--
C
L
N
A
K
L
D
SLAA
I
I
EKFCE
PQ
V
AIVSLT
I
TEKGYC
I
D
P
A
I
G
A
LD
T
S
NP
R
I
I
HDL
Q
NP
EE
P
H
SA
P
G
I
LVEAL
KR
RRE
R
GL
T
P
FTV
L
SCDNI
PD
NGHV
V
K
N
AVLG
M
A
E
K
R
S
-
PE
-
LA
G
WI
K
E
H
VSFP
G
TMVDRIVPAAT
N
E
S
LAEI
S
Q
H
LGV
N
DPCAI
S
CEPF
I
QWV
V
E
-----------
DNFV
A
GRP
A
W
EVA
GVQ
M
V
N
DV
L
P
W
EEMKLRMLNGSHSFLAYLGYL
S
G
FA
H
I
S
D
C
M
Q
D
RAF
R
H
AA
RT
LM
L
D
EQAPTL
R
I
K
D
-
V
DL
TQ
YA
DK
LI
A
RF
A
NP
A
LKH
K
TWQIAMDGSQK
-----
LPQR
M
LAG
I
R
I
HL
G
RE
T
D
W
SL
LALGVAGWMRY
VS
GVD
DA
GNAIDV
R
DP
L
--
S
D
K
I
R
E
L
V
A
V
SS
-----
SE
Q
RV
T
ALL
S
L
REI
F
G
DDLP
D
NP
H
FV
Q
A
I
EQ
A
W
QQI
A
Q
F
GA
HQ
A
L
fig|405955.9.peg.1950
Escherichia coli APEC O1 (25-485/491)
QL
Q
SRIVHFG
F
GAFHRAHQAL
L
TD
R
V
L
N
A
QG
G
DWGICE
I
S
L
FS
G
D
Q
--
L
MSQ
L
RA
Q
NH
LYTV
L
-----
EKGA
DG
N
Q
A
I
I
V
G
A
V
H
E
--
C
L
N
A
K
L
D
SLAA
I
I
EKFCE
PQ
V
AIVSLT
I
TEKGYC
I
D
P
A
I
G
A
LD
T
S
NP
R
I
I
HDL
Q
NP
EE
P
H
SA
P
G
I
LVEAL
KR
RRE
R
GL
T
P
FTV
L
SCDNI
PD
NGHV
V
K
N
AVLG
M
A
E
K
R
S
-
PE
-
LA
G
WI
K
E
H
VSFP
G
TMVDRIVPAAT
N
E
S
LAEI
S
Q
H
LGV
N
DPCAI
S
CEPF
I
QWV
V
E
-----------
DNFV
A
GRP
A
W
EVA
GVQ
M
V
N
DV
L
P
W
EEMKLRMLNGSHSFLAYLGYL
S
G
FA
H
I
S
D
C
M
Q
D
RAF
R
H
AA
RT
LM
L
D
EQAPTL
R
I
K
D
-
V
DL
TQ
YA
DK
LI
A
RF
A
NP
A
LKH
K
TWQIAMDGSQK
-----
LPQR
M
LAG
I
R
I
HL
G
RE
T
D
W
SL
LALGVAGWMRY
VS
GVD
DA
GNAIDV
R
DP
L
--
S
D
K
I
R
E
L
V
A
V
SS
-----
SE
Q
RV
T
ALL
S
L
REI
F
G
DDLP
D
NP
H
FV
Q
A
I
EQ
A
W
QQI
A
Q
F
GA
HQ
A
L
fig|585035.6.peg.2301
Escherichia coli S88 (22-482/488)
QL
Q
SRIVHFG
F
GAFHRAHQAL
L
TD
R
V
L
N
A
QG
G
DWGICE
I
S
L
FS
G
D
Q
--
L
MSQ
L
RA
Q
NH
LYTV
L
-----
EKGA
DG
N
Q
A
I
I
V
G
A
V
H
E
--
C
L
N
A
K
L
D
SLAA
I
I
EKFCE
PQ
V
AIVSLT
I
TEKGYC
I
D
P
A
I
G
A
LD
T
S
NP
R
I
I
HDL
Q
NP
EE
P
H
SA
P
G
I
LVEAL
KR
RRE
R
GL
T
P
FTV
L
SCDNI
PD
NGHV
V
K
N
AVLG
M
A
E
K
R
S
-
PE
-
LA
G
WI
K
E
H
VSFP
G
TMVDRIVPAAT
N
E
S
LAEI
S
Q
H
LGV
N
DPCAI
S
CEPF
I
QWV
V
E
-----------
DNFV
A
GRP
A
W
EVA
GVQ
M
V
N
DV
L
P
W
EEMKLRMLNGSHSFLAYLGYL
S
G
FA
H
I
S
D
C
M
Q
D
RAF
R
H
AA
RT
LM
L
D
EQAPTL
R
I
K
D
-
V
DL
TQ
YA
DK
LI
A
RF
A
NP
A
LKH
K
TWQIAMDGSQK
-----
LPQR
M
LAG
I
R
I
HL
G
RE
T
D
W
SL
LALGVAGWMRY
VS
GVD
DA
GNAIDV
R
DP
L
--
S
D
K
I
R
E
L
V
A
V
SS
-----
SE
Q
RV
T
ALL
S
L
REI
F
G
DDLP
D
NP
H
FV
Q
A
I
EQ
A
W
QQI
A
Q
F
GA
HQ
A
L
fig|869729.3.peg.1256
Escherichia coli UM146 (22-482/488)
QL
Q
SRIVHFG
F
GAFHRAHQAL
L
TD
R
V
L
N
A
QG
G
DWGICE
I
S
L
FS
G
D
Q
--
L
MSQ
L
RA
Q
NH
LYTV
L
-----
EKGA
DG
N
Q
A
I
I
V
G
A
V
H
E
--
C
L
N
A
K
L
D
SLAA
I
I
EKFCE
PQ
V
AIVSLT
I
TEKGYC
I
D
P
A
I
G
A
LD
T
S
NP
R
I
I
HDL
Q
NP
EE
P
H
SA
P
G
I
LVEAL
KR
RRE
R
GL
T
P
FTV
L
SCDNI
PD
NGHV
V
K
N
AVLG
M
A
E
K
R
S
-
PE
-
LA
G
WI
K
E
H
VSFP
G
TMVDRIVPAAT
N
E
S
LAEI
S
Q
H
LGV
N
DPCAI
S
CEPF
I
QWV
V
E
-----------
DNFV
A
GRP
A
W
EVA
GVQ
M
V
N
DV
L
P
W
EEMKLRMLNGSHSFLAYLGYL
S
G
FA
H
I
S
D
C
M
Q
D
RAF
R
H
AA
RT
LM
L
D
EQAPTL
R
I
K
D
-
V
DL
TQ
YA
DK
LI
A
RF
A
NP
A
LKH
K
TWQIAMDGSQK
-----
LPQR
M
LAG
I
R
I
HL
G
RE
T
D
W
SL
LALGVAGWMRY
VS
GVD
DA
GNAIDV
R
DP
L
--
S
D
K
I
R
E
L
V
A
V
SS
-----
SE
Q
RV
T
ALL
S
L
REI
F
G
DDLP
D
NP
H
FV
Q
A
I
EQ
A
W
QQI
A
Q
F
GA
HQ
A
L
fig|364106.7.peg.2480
Escherichia coli UTI89 (22-482/488)
QL
Q
SRIVHFG
F
GAFHRAHQAL
L
TD
R
V
L
N
A
QG
G
DWGICE
I
S
L
FS
G
D
Q
--
L
MSQ
L
RA
Q
NH
LYTV
L
-----
EKGA
DG
N
Q
A
I
I
V
G
A
V
H
E
--
C
L
N
A
K
L
D
SLAA
I
I
EKFCE
PQ
V
AIVSLT
I
TEKGYC
I
D
P
A
I
G
A
LD
T
S
NP
R
I
I
HDL
Q
NP
EE
P
H
SA
P
G
I
LVEAL
KR
RRE
R
GL
T
P
FTV
L
SCDNI
PD
NGHV
V
K
N
AVLG
M
A
E
K
R
S
-
PE
-
LA
G
WI
K
E
H
VSFP
G
TMVDRIVPAAT
N
E
S
LAEI
S
Q
H
LGV
N
DPCAI
S
CEPF
I
QWV
V
E
-----------
DNFV
A
GRP
A
W
EVA
GVQ
M
V
N
DV
L
P
W
EEMKLRMLNGSHSFLAYLGYL
S
G
FA
H
I
S
D
C
M
Q
D
RAF
R
H
AA
RT
LM
L
D
EQAPTL
R
I
K
D
-
V
DL
TQ
YA
DK
LI
A
RF
A
NP
A
LKH
K
TWQIAMDGSQK
-----
LPQR
M
LAG
I
R
I
HL
G
RE
T
D
W
SL
LALGVAGWMRY
VS
GVD
DA
GNAIDV
R
DP
L
--
S
D
K
I
R
E
L
V
A
V
SS
-----
SE
Q
RV
T
ALL
S
L
REI
F
G
DDLP
D
NP
H
FV
Q
A
I
EQ
A
W
QQI
A
Q
F
GA
HQ
A
L
fig|364106.8.peg.2481
Escherichia coli UTI89 (22-482/488)
QL
Q
SRIVHFG
F
GAFHRAHQAL
L
TD
R
V
L
N
A
QG
G
DWGICE
I
S
L
FS
G
D
Q
--
L
MSQ
L
RA
Q
NH
LYTV
L
-----
EKGA
DG
N
Q
A
I
I
V
G
A
V
H
E
--
C
L
N
A
K
L
D
SLAA
I
I
EKFCE
PQ
V
AIVSLT
I
TEKGYC
I
D
P
A
I
G
A
LD
T
S
NP
R
I
I
HDL
Q
NP
EE
P
H
SA
P
G
I
LVEAL
KR
RRE
R
GL
T
P
FTV
L
SCDNI
PD
NGHV
V
K
N
AVLG
M
A
E
K
R
S
-
PE
-
LA
G
WI
K
E
H
VSFP
G
TMVDRIVPAAT
N
E
S
LAEI
S
Q
H
LGV
N
DPCAI
S
CEPF
I
QWV
V
E
-----------
DNFV
A
GRP
A
W
EVA
GVQ
M
V
N
DV
L
P
W
EEMKLRMLNGSHSFLAYLGYL
S
G
FA
H
I
S
D
C
M
Q
D
RAF
R
H
AA
RT
LM
L
D
EQAPTL
R
I
K
D
-
V
DL
TQ
YA
DK
LI
A
RF
A
NP
A
LKH
K
TWQIAMDGSQK
-----
LPQR
M
LAG
I
R
I
HL
G
RE
T
D
W
SL
LALGVAGWMRY
VS
GVD
DA
GNAIDV
R
DP
L
--
S
D
K
I
R
E
L
V
A
V
SS
-----
SE
Q
RV
T
ALL
S
L
REI
F
G
DDLP
D
NP
H
FV
Q
A
I
EQ
A
W
QQI
A
Q
F
GA
HQ
A
L
fig|439855.10.peg.2489
Escherichia coli SMS-3-5 (22-482/488)
QL
Q
SRIVHFG
F
GAFHRAHQAL
L
TD
R
V
L
N
A
QG
G
DWGICE
I
S
L
FS
G
D
Q
--
L
MSQ
L
RA
Q
NH
LYTV
L
-----
EKGA
DG
N
Q
A
I
I
V
G
A
V
H
D
--
C
L
N
A
K
L
D
SLAA
I
I
EKFCE
PQ
V
AIVSLT
I
TEKGYC
I
D
P
A
T
G
A
LD
T
S
NP
R
I
I
HDL
Q
NP
EE
P
H
SA
P
G
I
LVEAL
KR
RRE
R
GL
A
P
FTV
L
SCDNI
PD
NGH
L
V
K
N
AVLG
M
A
E
K
R
S
-
PE
-
LA
G
WI
K
E
H
VSFP
G
TMVDRIVPAAT
D
E
S
LAEI
S
Q
H
LGV
N
DPCAI
S
CEPF
I
QWV
V
E
-----------
DNFV
A
GRP
A
W
EVA
GVQ
M
V
N
DV
L
P
W
EEMKLRMLNGSHSFLAYLGYL
S
G
FA
H
I
S
D
C
M
Q
D
RAF
R
H
AA
RT
LM
L
D
EQAPTL
R
I
K
D
-
F
DL
TQ
YA
DK
LI
A
RF
A
NP
A
LKH
K
TWQIAMDGSQK
-----
LPQR
M
LAG
I
R
I
HL
A
RE
T
D
W
SL
LALGVAGWMRY
VS
GVD
DA
GNAIDV
R
DP
L
--
S
D
K
I
C
E
L
V
A
G
SN
-----
SE
Q
RV
T
ALL
S
L
REV
F
S
DDLP
D
NP
H
FV
Q
A
I
EQ
A
W
QQI
A
Q
F
GA
HQ
A
L
fig|585057.4.peg.2408
Escherichia coli IAI39 (22-482/488)
QL
Q
SRIVHFG
F
GAFHRAHQAL
L
TD
R
V
L
N
A
QG
G
DWGICE
I
S
L
FS
G
D
Q
--
L
MSQ
L
RA
Q
NH
LYTV
L
-----
EKGA
DG
N
Q
A
I
I
V
G
A
V
H
D
--
C
L
N
A
K
L
D
SLAA
I
I
EKFCE
PQ
V
AIVSLT
I
TEKGYC
I
D
P
A
T
G
A
LD
T
S
NP
R
I
I
HDL
Q
NP
EE
P
H
SA
P
G
I
LVEAL
KR
RRE
R
GL
A
P
FTV
L
SCDNI
PD
NGHV
V
K
N
AVLG
M
A
E
K
R
S
-
PE
-
LA
G
WI
K
E
H
VSFP
G
TMVDRIVPAAT
D
E
S
LAEI
S
Q
H
LGV
N
DPCAI
S
CEPF
I
QWV
V
E
-----------
DNFV
A
GRP
A
W
EVA
GVQ
M
V
N
DV
L
P
W
EEMKLRMLNGSHSFLAYLGYL
S
G
FA
H
I
S
D
C
M
Q
D
RAF
R
H
AA
RT
I
M
L
D
EQAPTL
R
I
K
D
-
V
DL
TQ
YA
DK
LI
A
RF
A
NP
A
LKH
K
TWQIAMDGSQK
-----
LPQR
M
LAG
I
R
I
HL
A
RE
T
D
W
SL
LALGVAGWMRY
VS
GVD
DA
GNAIDV
R
DP
L
--
S
D
K
I
C
E
L
V
A
G
SN
-----
SE
Q
RV
T
ALL
S
L
REV
F
G
DDLP
D
NP
H
FV
Q
A
I
EQ
A
W
QQI
A
Q
F
GA
HQ
A
L
fig|585057.6.peg.2410
Escherichia coli IAI39 (22-482/488)
QL
Q
SRIVHFG
F
GAFHRAHQAL
L
TD
R
V
L
N
A
QG
G
DWGICE
I
S
L
FS
G
D
Q
--
L
MSQ
L
RA
Q
NH
LYTV
L
-----
EKGA
DG
N
Q
A
I
I
V
G
A
V
H
D
--
C
L
N
A
K
L
D
SLAA
I
I
EKFCE
PQ
V
AIVSLT
I
TEKGYC
I
D
P
A
T
G
A
LD
T
S
NP
R
I
I
HDL
Q
NP
EE
P
H
SA
P
G
I
LVEAL
KR
RRE
R
GL
A
P
FTV
L
SCDNI
PD
NGHV
V
K
N
AVLG
M
A
E
K
R
S
-
PE
-
LA
G
WI
K
E
H
VSFP
G
TMVDRIVPAAT
D
E
S
LAEI
S
Q
H
LGV
N
DPCAI
S
CEPF
I
QWV
V
E
-----------
DNFV
A
GRP
A
W
EVA
GVQ
M
V
N
DV
L
P
W
EEMKLRMLNGSHSFLAYLGYL
S
G
FA
H
I
S
D
C
M
Q
D
RAF
R
H
AA
RT
I
M
L
D
EQAPTL
R
I
K
D
-
V
DL
TQ
YA
DK
LI
A
RF
A
NP
A
LKH
K
TWQIAMDGSQK
-----
LPQR
M
LAG
I
R
I
HL
A
RE
T
D
W
SL
LALGVAGWMRY
VS
GVD
DA
GNAIDV
R
DP
L
--
S
D
K
I
C
E
L
V
A
G
SN
-----
SE
Q
RV
T
ALL
S
L
REV
F
G
DDLP
D
NP
H
FV
Q
A
I
EQ
A
W
QQI
A
Q
F
GA
HQ
A
L
fig|749527.3.peg.167
Escherichia coli MS 21-1 (22-482/488)
QL
Q
SRIVHFG
F
GAFHRAHQAL
L
TD
R
V
L
N
A
QG
G
DWGICE
I
S
L
FS
G
D
Q
--
L
MSQ
L
RA
Q
NH
LYTV
L
-----
EKGA
DG
N
Q
A
I
I
V
G
A
V
H
D
--
C
L
N
A
K
L
D
SLAA
I
I
EKFCE
PQ
V
AIVSLT
I
TEKGYC
I
D
P
A
T
G
A
LD
T
S
NP
R
I
I
HDL
Q
NP
EE
P
H
SA
P
G
I
LVEAL
KR
RRE
R
GL
A
P
FTV
L
SCDNI
PD
NGHV
V
K
N
AVLG
M
A
E
K
R
S
-
PE
-
LA
G
WI
K
E
H
VSFP
G
TMVDRIVPAAT
D
E
S
LAEI
S
Q
H
LGV
N
DPCAI
S
CEPF
I
QWV
V
E
-----------
DNFV
A
GRP
A
W
EVA
GVQ
M
V
N
DV
L
P
W
EEMKLRMLNGSHSFLAYLGYL
S
G
FA
H
I
S
D
C
M
Q
D
RAF
R
H
AA
RT
LM
L
D
EQAPTL
R
I
K
D
-
V
DL
TQ
YA
DK
LI
A
RF
A
NP
A
LKH
K
TWQIAMDGSQK
-----
LPQR
M
LAG
I
R
I
HL
A
RE
T
D
W
SL
LALGVAGWMRY
VS
GVD
DA
GNAIDV
R
DP
L
--
S
D
K
I
C
E
L
V
A
G
SN
-----
SE
Q
RV
T
ALL
S
L
REV
F
G
DDLP
D
NP
H
FV
Q
A
I
EQ
A
W
QQI
A
Q
F
GA
HQ
A
L
Consen1
Primary consensus
MKTLNRrdfpgaql
sRIvhfG
GaFhRAhqal
td
lle
td
dwGicev
l
gs
--
l
L
Q
LYTv
-----
EKGa
sda
iigsv
e
--
ly
e
D
il
Pq
aiVslt
TEkGyc
d
A
g
lD
dnP
i
hdl
np
P
sa
g
lvEal
rre
glk
ftvisCdni
NGhv
k
aVLg
Aq
r
-
Pe
-
la
Wide
vsFp
TmVDRIVpaat
e
laei
e
LGvhDpcaitcEpF
qwVie
-----------
Dnfv
grp
w
gvq
V
Dv
PyeemKlrmLNGsHsfLaylgyl
G
ti
d
M
d
r
aa
lm
eEqaPtL
lp
-
dL
yA
li
RF
NP
lkHqtwqIAmdGsqK
-----
LPQrlLag
r
hl
ngt
w
LalgvAgwmry
Gvd
GnaidV
Dp
--
l
r
qql
aq
-----
erV
alL
l
f
dDLpqnp
fV
av
a
qqi
e
GareavraLC
Consen2
Secondary consensus
pswdhsry
e
iql
n
l
fvdw
ih
vnn
qg
ns
vvvi
p
t
rvf
t
irgln
e
l
lvram
rei
v
k
fi
e
rf
fsn
a
is
h
d
f
a
v
y
--
--
kl
r
if
rf
fng
ldt
wii
p
elv
da
r
l
r
e
w
l
qafi
l
q
nt
c
l
tgyp
d
vqkl
y
gfld
a
h
lf
vqgpkslatelrl
ky
-
---
-
nal
i
kmr
vai
a
ta
vpvafq
hv
e
n
c
fv
ai
ii
v
k
g
e
f
vt
ir
lls
ln
mt
frtri
-
m
dp
k
--
reg
p
tfal
aliaf
-
e
etyp
d
hws
r
i
sg
drvig
l
iv
e
w
q
tdva
l
qi
d
dal
q
mhqclap
Consensus 1
(when a gap)
Conservative difference
Consensus 2
(when a gap)
Nonconservative diff.
Other character