┌─ Escherichia coli (114-167/225) 042   
                                               ├─ Escherichia coli (114-167/225) 2362-75   
                                               ├─ Escherichia coli (114-167/225) 2362-75   
                                               ├─ Escherichia coli (114-167/225) 2362-75   
                                               ├─ Escherichia coli (114-167/225) 2362-75   
                                               ├─ Escherichia coli (104-157/215) CFT073   
                                               ├─ Escherichia coli (114-167/225) E110019   
                                               ├─ Escherichia coli (114-167/225) E110019   
                                               ├─ Escherichia coli (104-157/215) E110019   
                                               ├─ Escherichia coli (104-157/215) E22   
                                               ├─ Escherichia coli (104-157/215) E22   
                                               ├─ Escherichia coli (127-180/238) E22   
                                               ├─ Escherichia coli (114-167/225) E24377A   
                                              ┌┼─ Escherichia coli (43-96/154) E24377A   
                                              │├─ Escherichia coli (114-167/225) E24377A   
                                              │├─ Escherichia coli (82-135/193) E22   
                                              │├─ Escherichia coli (104-157/215) E22   
                                              │├─ Escherichia coli (104-157/215) E22   
                                              │├─ Escherichia coli (114-167/225) E110019   
                                              │├─ Escherichia coli (114-167/225) E110019   
                                        ┌─────┤├─ Escherichia coli (114-167/225) E110019   
                                        │     │├─ Escherichia coli (114-167/225) 2362-75   
                                        │     │├─ Escherichia coli (114-167/225) 2362-75   
                                        │     │├─ Escherichia coli (114-167/225) 2362-75   
                                        │     │├─ Escherichia coli (114-167/225) 2362-75   
                                        │     │└─ Escherichia coli (114-167/225) 2362-75   
                                        │     │ ┌─ Escherichia coli (114-167/225) B171   
        ┌───────────────────────────────┤     └─┼─ Escherichia coli (114-167/225) B171   
        │                               │       └─ Escherichia coli (114-167/225) B171   
        │                               │                        ┌─ Escherichia coli (105-169/216) H299   
        │                               │                    ┌───┼─ Escherichia coli (105-169/216) MS 182-1   
        │                               │                    │   └─ Escherichia coli (105-169/216) MS 124-1   
        │                               │                    │┌─ Escherichia coli (19-72/127) 53638   
        │                               │                    ││┌─ Escherichia coli (105-169/213) 53638   
        │                               └────────────────────┤│├─ Escherichia coli (105-169/213) 53638   
        │                                                    ││├─ Escherichia coli (105-169/213) 53638   
        │                                                    ││├─ Escherichia coli (105-169/213) 53638   
        │                                                    ││├─ Escherichia coli (105-169/213) 53638   
        │                                                    └┤├─ Escherichia coli (105-169/213) 53638   
        │                                                     │├─ Escherichia coli (105-169/213) 53638   
        │                                                     │├─ Escherichia coli (105-169/213) 53638   
        │                                                     │├─ Escherichia coli (105-169/213) 53638   
        │                                                     │├─ Escherichia coli (105-169/213) 53638   
        │                                                     │├─ Escherichia coli (105-169/213) 53638   
        │                                                     │├─ Escherichia coli (105-169/213) 53638   
        │                                                     └┼─ Escherichia coli (105-169/213) 53638   
        │                                                      ├─ Escherichia coli (105-169/213) 53638   
┌───────┤                                                      ├─ Escherichia coli (105-169/213) 53638   
│       │                                                      ├─ Escherichia coli (105-169/213) 53638   
│       │                                                      ├─ Escherichia coli (105-169/213) 53638   
│       │                                                      ├─ Escherichia coli (105-169/213) 53638   
│       │                                                      ├─ Escherichia coli (105-169/213) 53638   
│       │                                                      ├─ Escherichia coli (105-169/213) 53638   
│       │                                                      ├─ Escherichia coli (105-169/213) 53638   
│       │                                                      ├─ Escherichia coli (105-169/213) 53638   
│       │                                                      ├─ Escherichia coli (105-169/213) 53638   
│       │                                                      ├─ Escherichia coli (105-169/213) 53638   
│       │                                                      └─ Escherichia coli (59-123/167) 53638   
│       │                                  ┌─ Escherichia coli (22-78/134) O26:H11 str. 11368   
│       │                                 ┌┴─ Escherichia coli (22-78/134) O26:H11 str. 11368   
│       │                                 │┌─ Escherichia coli (22-95/134) H299   
│       │                                 ││┌─ fig|1040638.4.peg.210 O104:H4 (22-78/134) str. LB226692   
│       │                                 ││├─ Escherichia coli (22-78/134) B171   
│       │                                 ││├─ Escherichia coli (22-78/134) B171   
│       │                                 ││├─ Escherichia coli (22-78/134) B171   
│       │                                 ││├─ Escherichia coli (22-78/134) B171   
│       └─────────────────────────────────┤│├─ Escherichia coli (22-78/134) B171   
│                                         ││├─ Escherichia coli (22-78/134) B171   
│                                         ││├─ Escherichia coli (22-78/134) B171   
│                                         ││├─ Escherichia coli (22-78/134) B171   
│                                         ││├─ Escherichia coli (22-78/134) B171   
│                                         ││├─ Escherichia coli (22-78/134) CFT073   
│                                         ││├─ Escherichia coli (22-78/134) E110019   
│                                         └┤├─ Escherichia coli (22-78/134) E110019   
│                                          │├─ Escherichia coli (22-78/134) E22   
│                                          │├─ Escherichia coli (22-78/134) ED1a   
│                                          │├─ Escherichia coli (22-78/134) F11   
│                                          │├─ Escherichia coli (22-78/134) FVEC1302   
│                                          │├─ Escherichia coli (22-78/134) FVEC1412   
│                                          │├─ Escherichia coli (22-78/134) MS 175-1   
│                                          │├─ Escherichia coli (22-78/134) MS 198-1   
│                                          │├─ Escherichia coli (22-78/134) O26:H11 str. 11368   
│                                          │├─ Escherichia coli (22-78/134) O26:H11 str. 11368   
│                                          │├─ Escherichia coli (22-78/134) O55:H7 str. CB9615   
│                                          │├─ Escherichia coli (22-78/134) UM146   
│                                          │├─ Escherichia coli (22-78/134) UMN026   
│                                          └┼─ Escherichia coli (22-78/134) UTI89   
│                                           ├─ Escherichia coli (22-78/134) UTI89   
│                                           ├─ Escherichia coli (22-78/134) UMN026   
│                                           ├─ Escherichia coli (22-78/134) SE15   
│                                           ├─ Escherichia coli (22-78/134) O26:H11 str. 11368   
│                                           ├─ Escherichia coli (22-78/134) O26:H11 str. 11368   
│                                           ├─ Escherichia coli (22-78/134) MS 69-1   
│                                           ├─ Escherichia coli (22-78/134) MS 185-1   
│                                           ├─ Escherichia coli (22-78/134) MS 116-1   
│                                           ├─ Escherichia coli (22-78/134) FVEC1412   
│                                           ├─ Escherichia coli (22-78/134) F11   
│                                           ├─ Escherichia coli (22-78/134) ED1a   
│                                           ├─ Escherichia coli (22-78/134) E22   
│                                           ├─ Escherichia coli (22-78/134) E110019   
│                                           ├─ Escherichia coli (22-78/134) E110019   
│                                           ├─ Escherichia coli (22-78/134) CFT073   
│                                           ├─ Escherichia coli (22-78/134) B171   
│                                           ├─ Escherichia coli (22-78/134) B171   
│                                           ├─ Escherichia coli (22-78/134) B171   
│                                           ├─ Escherichia coli (22-78/134) B171   
┤                                           ├─ Escherichia coli (22-78/134) B171   
│                                           ├─ Escherichia coli (22-78/134) B171   
│                                           ├─ Escherichia coli (22-78/134) B171   
│                                           ├─ Escherichia coli (22-78/134) B171   
│                                           ├─ Escherichia coli (22-78/134) B171   
│                                           ├─ fig|6666666.5357.peg.4488 TY-2482 (22-78/134) strain   
│                                           └─ Escherichia coli (22-78/134) MS 21-1   
│                                                     ┌─ fig|1040638.4.peg.2517 O104:H4 (23-89/144) str. LB226692   
│                                                     ├─ Escherichia coli (23-89/144) 55989   
│                                                     ├─ Escherichia coli (23-89/144) 55989   
│                                                     ├─ Escherichia coli (23-89/144) FVEC1302   
│                                                     ├─ Escherichia coli (23-89/144) MS 69-1   
│                                                     ├─ Escherichia coli (24-90/145) 042   
│                                                    ┌┼─ fig|6666666.5357.peg.3445 TY-2482 (23-89/144) strain   
│                                                    │├─ Escherichia coli (24-90/145) CFT073   
│                                                    │├─ Escherichia coli (23-89/144) UMN026   
│                                                    │├─ Escherichia coli (23-89/144) MS 198-1   
│                               ┌────────────────────┤├─ Escherichia coli (23-89/144) ED1a   
│                               │                    │├─ Escherichia coli (23-89/144) 55989   
│                               │                    │└─ Escherichia coli (23-89/144) 042   
│                          ┌────┤                    └┬─ Escherichia coli (23-89/144) TA280   
│                          │    │                     └─ Escherichia coli (24-91/125) B088   
│                          │    └───────────────────────────┬─── Escherichia coli (24-86/136) TA271   
│                          │                                └─ Escherichia coli (24-86/136) MS 182-1   
│                          │                   ┌─ Escherichia coli (1-69/120) 042   
│                          │                   ├─ Escherichia coli (1-69/120) 55989   
│                          │                   ├─ Escherichia coli (1-69/120) E110019   
│                          │                   ├─ Escherichia coli (22-90/118) H591   
│                          │                   ├─ Escherichia coli (1-69/120) O111:H- str. 11128   
│                          │                   ├─ Escherichia coli (1-69/120) O157:H7 str. FRIK2000   
│                          │                   ├─ Escherichia coli (1-69/120) SE15   
│                          │                   ├─ Escherichia coli (1-69/120) SE15   
│                          │                   ├─ Escherichia coli (1-69/120) SE15   
│                          │                   ├─ Escherichia coli (1-69/77) E22   
│                          │                   ├─ Escherichia coli (25-93/144) E110019   
│                          │                   ├─ Escherichia coli (22-90/124) ED1a   
│                          │                   ├─ fig|1040638.4.peg.682 O104:H4 (22-90/141) str. LB226692   
│                          │                   ├─ Escherichia coli (22-90/141) E110019   
│                          │                   ├─ Escherichia coli (22-90/141) E110019   
│                          │                   ├─ Escherichia coli (22-90/141) ED1a   
│                          │                   ├─ Escherichia coli (22-90/141) H591   
│                          │                   ├─ Escherichia coli (22-90/141) SMS-3-5   
│                          │                  ┌┼─ Escherichia coli (22-90/98) E22   
│                          │                  │├─ Escherichia coli (22-90/141) MS 145-7   
│                          │                  │├─ Escherichia coli (22-90/141) ETEC H10407   
│                          │                  │├─ Escherichia coli (22-90/141) E110019   
│                          │                  │├─ Escherichia coli (22-90/141) E110019   
│                          │                  │├─ Escherichia coli (22-90/141) 042   
│                          │                  │├─ Escherichia coli (22-90/141) H299   
│                          │                  │├─ Escherichia coli (22-90/124) ED1a   
│                          │                  │├─ Escherichia coli (1-69/77) O103:H2 str. 12009   
│                          │                 ┌┤├─ Escherichia coli (1-69/120) SE15   
│                          │                 ││├─ Escherichia coli (1-69/120) SE15   
│                          │                 ││├─ Escherichia coli (1-69/120) SE15   
│                          │                 ││├─ Escherichia coli (1-69/120) O157:H7 str. FRIK966   
│                          │                 ││├─ Escherichia coli (1-69/120) O157:H7 str. EC869   
│                          │                 ││├─ Escherichia coli (1-69/120) MS 107-1   
│                          │                 ││├─ Escherichia coli (1-69/120) E110019   
│                          │                 ││├─ Escherichia coli (1-69/120) 55989   
│                          │                ┌┤│└─ Escherichia coli (1-69/120) 55989   
└──────────────────────────┤                ││└┬─ Escherichia coli (14-71/122) MS 175-1   
                           │                ││ └┬─ Escherichia coli (22-90/141) HS   
                           │                ││  └─ Escherichia coli (1-69/120) HS   
                           │                ││ ┌─ Escherichia coli (1-69/120) O103:H2 str. 12009   
                           │                ││┌┼─ Escherichia coli (1-69/120) O55:H7 str. CB9615   
                           │                │││└─ Escherichia coli (1-69/120) O103:H2 str. 12009   
                           │                │└┤┌─ Escherichia coli (1-69/120) B171   
                           │               ┌┤ │├─ Escherichia coli (22-90/141) B171   
                           │               ││ │├─ Escherichia coli (22-90/141) E2348/69   
                           │               ││ └┼─ Escherichia coli (22-90/141) O127:H6 str. E2348/69   
                           │               ││  ├─ Escherichia coli (22-90/141) E22   
                           │               ││  ├─ Escherichia coli (1-69/120) E22   
                           │               ││  └─ Escherichia coli (1-69/120) 2362-75   
                           │               ││ ┌─ Escherichia coli (22-86/141) E110019   
                           │               ││┌┴─ Escherichia coli (22-86/141) E110019   
                           │              ┌┤└┤┌─ fig|1040638.4.peg.979 O104:H4 (22-90/141) str. LB226692   
                           │              ││ └┤┌─ Escherichia coli (1-69/120) 55989   
                           │              ││  │├─ Escherichia coli (22-90/141) ED1a   
                           │              ││  └┼─ Escherichia coli (22-90/141) S88   
                           │              ││   ├─ Escherichia coli (22-90/141) ED1a   
                           │            ┌─┤│   ├─ Escherichia coli (22-90/141) EC4100B   
                           │            │ ││   └─ Escherichia coli (1-69/120) 55989   
                           │            │ │└─┬── fig|1040638.4.peg.356 O104:H4 (1-70/112) str. LB226692   
                           │            │ │  └── Escherichia coli (1-69/80) O103:H2 str. 12009   
                           │        ┌───┤ │      ┌─ Escherichia coli (1-69/120) 536   
                           │        │   │ └──────┼─ Escherichia coli (1-69/120) MS 200-1   
                           │        │   │        ├─ Escherichia coli (1-69/120) F11   
                           │        │   │        └─ Escherichia coli (1-69/120) 536   
                           │        │   └─┬── Escherichia coli (1-69/137) O26:H11 str. 11368   
                           │        │     └─── Escherichia coli (1-69/111) M605   
                           │        │      ┌─ Escherichia coli (1-69/120) 1212A   
                           │        │      ├─ Escherichia coli (1-69/120) MS 200-1   
                           │        │      ├─ Escherichia coli (1-69/120) O157:H7 EDL933   
                           │        │      ├─ Escherichia coli (1-69/120) O157:H7 str. EC4042   
                           │        │      ├─ Escherichia coli (1-69/120) O157:H7 str. EC4076   
                           │        │      ├─ Escherichia coli (1-69/120) O157:H7 str. EC4115   
                           │        │      ├─ Escherichia coli (1-69/120) O157:H7 str. EC4206   
                           │        │      ├─ Escherichia coli (1-69/120) O157:H7 str. EC508   
                           │        │      ├─ Escherichia coli (1-69/120) O157:H7 str. FRIK2000   
                           │        │      ├─ Escherichia coli (1-69/120) O157:H7 str. Sakai   
                           └────────┤      ├─ Escherichia coli (1-69/120) O157:H7 str. TW14588   
                                    │      ├─ Escherichia coli (22-90/141) O157:H7 EDL933   
                                    │      ├─ Escherichia coli (22-90/141) 1125A   
                                    │      ├─ Escherichia coli (22-90/141) O157:H7   
                                    │      ├─ Escherichia coli (22-90/141) O157:H7 str. EC4486   
                                    │   ┌──┼─ Escherichia coli (22-90/141) O157:H7 str. EC4501   
                                    │   │  ├─ Escherichia coli (22-90/141) O157:H7 EDL933   
                                    │   │  ├─ Escherichia coli (22-90/141) MS 116-1   
                                    │   │  ├─ Escherichia coli (22-90/141) 1044A   
                                    │   │  ├─ Escherichia coli (1-69/120) O26:H11 str. 11368   
                                    │   │  ├─ Escherichia coli (1-69/120) O157:H7 str. TW14359   
                                    │   │  ├─ Escherichia coli (1-69/120) O157:H7 str. FRIK966   
                                    │   │  ├─ Escherichia coli (1-69/120) O157:H7 str. EC869   
                                    │   │  ├─ Escherichia coli (1-69/120) O157:H7 str. EC4401   
                                    │   │  ├─ Escherichia coli (1-69/120) O157:H7 str. EC4196   
                                    │   │  ├─ Escherichia coli (1-69/120) O157:H7 str. EC4113   
                                    └───┤  ├─ Escherichia coli (1-69/120) O157:H7 str. EC4045   
                                        │  ├─ Escherichia coli (1-69/120) O157:H7 str. EC4024   
                                        │  ├─ Escherichia coli (1-69/120) O157:H7 EDL933   
                                        │  └─ Escherichia coli (1-69/120) 536A   
                                        │  ┌─ Escherichia coli (22-90/131) MS 198-1   
                                        │  ├─ Escherichia coli (1-69/120) FVEC1412   
                                        │ ┌┼─ Escherichia coli (1-69/120) UMN026   
                                        │ │└─ Escherichia coli (1-69/120) FVEC1302   
                                        │┌┤┌─ Escherichia coli (1-69/120) MS 69-1   
                                        ││└┼─ Escherichia coli (22-90/141) ABU 83972   
                                        ││ └─ Escherichia coli (1-69/120) CFT073   
                                        ││┌─── Escherichia coli (22-92/141) 536   
                                        └┤│       ┌─ Escherichia coli (26-96/145) F11   
                                         ││       ├─ Escherichia coli (1-71/120) 536   
                                         ││┌──────┼─ Escherichia coli (1-71/120) F11   
                                         │││      └─ Escherichia coli (1-71/120) 536   
                                         └┤│  ┌─ Escherichia coli (1-69/120) 1044A   
                                          ││  ├─ Escherichia coli (1-69/120) 1212A   
                                          ││  ├─ Escherichia coli (1-69/120) E110019   
                                          ││  ├─ Escherichia coli (1-69/120) O157:H7 str. EC4206   
                                          ││  ├─ Escherichia coli (1-69/120) O26:H11 str. 11368   
                                          └┤ ┌┼─ Escherichia coli (22-90/141) O157:H7 str. EC4486   
                                           │ │├─ Escherichia coli (22-90/141) O157:H7   
                                           │ │├─ Escherichia coli (1-69/120) O157:H7 str. EC4401   
                                           │┌┤├─ Escherichia coli (1-69/120) O157:H7 str. EC4076   
                                           │││├─ Escherichia coli (1-69/120) 536A   
                                           │││└─ Escherichia coli (1-69/120) 1125A   
                                           ││└┬─ Escherichia coli (22-90/141) O157:H7 EDL933   
                                           └┤ └─ Escherichia coli (22-90/141) O157:H7 EDL933   
                                            │ ┌─ Escherichia coli (1-69/120) ABU 83972   
                                            │┌┴─ Escherichia coli (1-69/120) MS 185-1   
                                            ││ ┌─ Escherichia coli (1-69/120) F11   
                                            └┤ ├─ Escherichia coli (1-69/120) UTI89   
                                             │┌┼─ Escherichia coli (1-69/120) UTI89   
                                             ││└─ Escherichia coli (1-69/120) UM146   
                                             └┤              ┌───── fig|6666666.5357.peg.4616 TY-2482 (22-83/84) strain   
                                              │              │        ┌─ fig|1040638.4.peg.416 O104:H4 str. LB226692   
                                              │              │      ┌─┼─ Escherichia coli ED1a   
                                              └──────────────┤      │ └─ Escherichia coli 55989   
                                                             │      │ ┌─ Escherichia coli (22-91/94) TA271   
                                                             │      │ ├─ Escherichia coli (1-70/73) ETEC H10407   
                                                             └──────┤ ├─ Escherichia coli (1-70/73) MS 84-1   
                                                                    │┌┼─ Escherichia coli (1-70/73) NC101   
                                                                    ││├─ Escherichia coli (1-70/73) MS 124-1   
                                                                    ││└─ Escherichia coli (22-91/94) MS 200-1   
                                                                    ││┌─ Escherichia coli (22-83/84) 55989   
                                                                    └┤├─ Escherichia coli (22-83/84) 83972   
                                                                     │├─ Escherichia coli (22-83/84) SE15   
                                                                     │├─ Escherichia coli (1-62/63) 042   
                                                                     │├─ Escherichia coli (1-62/63) H299   
                                                                     │├─ Escherichia coli (1-62/63) MS 45-1   
                                                                     └┼─ Escherichia coli (1-62/63) TA206   
                                                                      ├─ Escherichia coli (1-62/63) MS 185-1   
                                                                      ├─ Escherichia coli (1-62/63) ABU 83972   
                                                                      ├─ fig|1040638.4.peg.670 O104:H4 (1-62/63) str. LB226692   
                                                                      ├─ Escherichia coli (22-83/84) CFT073   
                                                                      ├─ Escherichia coli (22-83/84) 55989   
                                                                      └─ Escherichia coli (22-83/84) 042   
  
ISSfl3 orfA (119)
Insertion Sequence Associated (59)
unknown in ISEc8 (29)
hypothetical protein (21)
IS, phage, Tn; Transposon-related functions (18)
transposase 3 (13)
conserved hypothetical protein (6)
unknown in putative ISEc8 (2)
COG2963: Transposase and inactivated derivatives (1)
Unknown in ISEc8 (1)
Unknown protein encoded by ISEc8 (1)
Others (10)