fig|1040638.4.peg.415
Escherichia coli O104:H4 str. LB226692
MLSFNMTTLH
Y
Y
LK
EAL
L
NIIENRR
QNFA
FLVFL
S
LSF
I
GIIITDSLI
Y
SVS
L
KAEEELK
VH
SD
KV
IFVK
L
YR
PK
T
VGY
IT
EK
F
ITVS-
K
V
L
S
FSK
N
AFL
Y
VSDTPFS
GE
L
FS
V
S
GID
-
-
-----
K
LGL
N
TE
Y
S
G
DLNDKY
--
NG
N
V
AIV
NESS
PF
FS
KK
Q
IFING
V
PFK
I
IGVR
L
N
S
KT
D
FLDSLGLKA
N
Q
S
D
EHI
FIPLET
MF
K
M
KL
D
N
RV
NAVKI
F
LD
NI
V
TKR
DI
NN
VK
R
V
L
YD
N
D
I
R
K
F
D
I
V
T
S
LNAKEAVD
R
VL
E
RFSLLTN
S
VY
V
ILT
LS
A
S
V
T
CFI
LSKR
S
F
Y
S
R
R
V
E
LS
LKIIHGT
E
K
-
K
E
IT
V
LIIIESLIM
L
SVCL
F
ISL
IHAGV
I
MHI
I
KYF
LDV
TIS
IR
T
TMIT
I
SLA
N
V
LLVF
I
FA
NI
IF
SR
L
FFSINPVNAIKGKIE
fig|585055.8.peg.5134
Escherichia coli 55989
MLSFNMTTLH
Y
Y
LK
EAL
L
NIIENRR
QNFA
FLVFL
S
LSF
I
GIIITDSLI
Y
SVS
L
KAEEELK
VH
SD
KV
IFVK
L
YR
PK
T
VGY
IT
EK
F
ITVS-
K
V
L
S
FSK
N
AFL
Y
VSDTPFS
GE
L
FS
V
S
GID
-
-
-----
K
LGL
N
TE
Y
S
G
DLNDKY
--
NG
N
V
AIV
NESS
PF
FS
KK
Q
IFING
V
PFK
I
IGVR
L
N
S
KT
D
FLDSLGLKA
N
Q
S
D
EHI
FIPLET
MF
K
M
KL
D
N
RV
NAVKI
F
LD
NI
V
TKR
DI
NN
VK
R
V
L
YD
N
D
I
R
K
F
D
I
V
T
S
LNAKEAVD
R
VL
E
RFSLLTN
S
VY
V
ILT
LS
A
S
V
T
CFI
LSKR
S
F
Y
S
R
R
V
E
L
ALKIIHGT
E
K
-
K
E
IT
V
LIIIESLIM
L
SVCL
F
ISL
IHAGV
I
MHI
I
KYF
LDV
TIS
IR
T
TMIT
I
SLA
N
V
LLVF
I
FA
NI
IF
SR
L
FFSINPVNAIKGKIE
fig|585397.6.peg.69
Escherichia coli ED1a
MLSFNMTTLH
Y
Y
LK
EAL
L
NIIENRR
QNFA
FLVFL
S
LSF
I
GIIITDSLI
Y
SVS
L
KAEEELK
VH
SD
KV
IFVK
L
YR
PK
T
VGY
IT
EK
F
ITVS-
K
V
L
S
FSK
N
AFL
Y
VSDTPFS
GE
L
FS
V
S
GID
-
-
-----
K
LGL
N
TE
Y
S
G
DLNDKY
--
NG
N
V
AIV
NESS
PF
FS
KK
Q
IFING
V
PFK
I
IGVR
L
N
S
KT
D
FLDSLGLKA
N
Q
S
D
EHI
FIPLET
MF
K
M
KL
D
N
RV
NAVKI
F
LD
NI
V
TKR
DI
NN
VK
R
V
L
YD
N
D
I
R
K
F
D
I
V
T
S
LNAKEAVD
R
VL
E
RFSLLTN
S
VY
V
ILT
LS
A
S
V
T
CFI
LSKR
S
F
Y
S
R
R
V
E
L
ALKIIHGT
E
K
-
K
E
IT
V
LIIIESLIM
L
SVCL
F
ISL
IHAGV
I
MHI
I
KYF
LDV
TIS
IR
T
TMIT
I
SLA
N
V
LLVF
I
FA
NI
IF
SR
L
FFSINPVNAIKGKIE
fig|216592.1.peg.5151
Escherichia coli 042 (8-387/387)
LSFNMTTLH
Y
Y
LN
EAL
L
NIIENRR
QNFA
FLVFL
S
LSF
I
GIIITDSLI
Y
SVS
L
KAEEELK
VH
SD
KV
IFVK
L
YR
PK
T
VGY
IT
EK
F
ITVS-
K
V
L
S
FSK
S
AFL
Y
VSDTPFS
GE
L
FS
V
N
GID
-
-
-----
K
LGL
N
TE
Y
S
G
DLNDKY
--
NG
N
V
AIV
NESS
PF
FS
KK
Q
IFING
V
PFK
I
IGVR
L
N
S
KT
D
FLDSLGLKA
S
Q
S
D
EHI
FIPLET
MF
K
V
KL
D
N
RV
NAVKI
F
LD
NI
V
TKR
DI
NN
VK
R
V
L
YD
N
D
I
R
K
F
D
I
V
T
S
LNAKEAVD
R
VL
E
RFSLLTN
S
VY
V
ILT
LS
A
S
V
T
CFI
LSKR
S
F
Y
S
R
R
V
E
LS
LKIIHGT
E
K
-
K
E
IT
V
LIIIESLIM
L
SVCL
F
IS
V
IYAGV
I
MHI
I
KYF
LDV
TIS
IR
T
TMIT
I
SLA
N
V
LLVF
I
SA
NI
IF
G
R
L
FFSINPVNAIKGKIE
fig|216592.3.peg.5103
Escherichia coli 042
MTTLH
Y
Y
LN
EAL
L
NIIENRR
QNFA
FLVFL
S
LSF
I
GIIITDSLI
Y
SVS
L
KAEEELK
VH
SD
KV
IFVK
L
YR
PK
T
VGY
IT
EK
F
ITVS-
K
V
L
S
FSK
S
AFL
Y
VSDTPFS
GE
L
FS
V
N
GID
-
-
-----
K
LGL
N
TE
Y
S
G
DLNDKY
--
NG
N
V
AIV
NESS
PF
FS
KK
Q
IFING
V
PFK
I
IGVR
L
N
S
KT
D
FLDSLGLKA
S
Q
S
D
EHI
FIPLET
MF
K
V
KL
D
N
RV
NAVKI
F
LD
NI
V
TKR
DI
NN
VK
R
V
L
YD
N
D
I
R
K
F
D
I
V
T
S
LNAKEAVD
R
VL
E
RFSLLTN
S
VY
V
ILT
LS
A
S
V
T
CFI
LSKR
S
F
Y
S
R
R
V
E
LS
LKIIHGT
E
K
-
K
E
IT
V
LIIIESLIM
L
SVCL
F
IS
V
IYAGV
I
MHI
I
KYF
LDV
TIS
IR
T
TMIT
I
SLA
N
V
LLVF
I
SA
NI
IF
G
R
L
FFSINPVNAIKGKIE
fig|340185.3.peg.3777
Escherichia coli E22 (43-413/414)
L
K
L
Y
CI
EA
F
C
N
L
IEN
K
R
NTIV
F
F
VFL
T
LSFTGII
TV
DSLI
F
SVS
Q
KAE
S
ELK
IS
G
D
NT
VT
VKF
PS
HL
S
IDF
LS
SL
F
EKSQF
E
I
M
F
F
-
K
K
AFL
V
VSDTPFS
DN
V
ET
V
M
G
V
N
S
E
QIKKW
K
IET
D
GV
F
T
G
------
--
--
N
A
V
IV
SSEQ
LI
DT
Q
K
K
LY
IN
S
IPF
N
V
IGVR
K
K
K
I
T
H
FLDSLGLK
S
T
D
I
H
AKY
FIPLET
LN
R
L
T
L
K
H
TA
DSIEL
T
TK
RK
I
LVS
D
L
EE
I
K
E
LL
SS
H
E
I
M
D
Y
V
I
T
S
Y
L
D
AKE
T
V
R
NV
M
V
RFSL
V
TN
F
VY
I
ILT
SI
S
L
I
V
VST
I
CR
R
N
FQ
L
R
G
TEFALKIIHG
I
G
GNS
L
I
C
I
V
I
L
-
E
T
LI
V
N
LL
CL
I
T
SL
KLCLI
L
FTF
L
MPL
L
N
S
EFH
L
R
F
D
MI
G
C
A
L
F
I
V
TATC
C
IT
S
I
LT
G
R
R
F
LNKD
P
IDI
IK
HRM
fig|340185.4.peg.3971
Escherichia coli E22 (43-413/414)
L
K
L
Y
CI
EA
F
C
N
L
IEN
K
R
NTIV
F
F
VFL
T
LSFTGII
TV
DSLI
F
SVS
Q
KAE
S
ELK
IS
G
D
NT
VT
VKF
PS
HL
S
IDF
LS
SL
F
EKSQF
E
I
M
F
F
-
K
K
AFL
V
VSDTPFS
DN
V
ET
V
M
G
V
N
S
E
QIKKW
K
IET
D
GV
F
T
G
------
--
--
N
A
V
IV
SSEQ
LI
DT
Q
K
K
LY
IN
S
IPF
N
V
IGVR
K
K
K
I
T
H
FLDSLGLK
S
T
D
I
H
AKY
FIPLET
LN
R
L
T
L
K
H
TA
DSIEL
T
TK
RK
I
LVS
D
L
EE
I
K
E
LL
SS
H
E
I
M
D
Y
V
I
T
S
Y
L
D
AKE
T
V
R
NV
M
V
RFSL
V
TN
F
VY
I
ILT
SI
S
L
I
V
VST
I
CR
R
N
FQ
L
R
G
TEFALKIIHG
I
G
GNS
L
I
C
I
V
I
L
-
E
T
LI
V
N
LL
CL
I
T
SL
KLCLI
L
FTF
L
MPL
L
N
S
EFH
L
R
F
D
MI
G
C
A
L
F
I
V
TATC
C
IT
S
I
LT
G
R
R
F
LNKD
P
IDI
IK
HRM
fig|358709.5.peg.2519
Escherichia coli 101-1 (9-365/377)
L
K
-
-
--
E
S
L
Q
NI
Q
EN
K
N
MMYL
Y
L
FV
L
I
LSFTG
V
IITDSLI
N
SVS
K
T
A
Q
T
EL
R
DE
G
D
SI
I
TIN
F
HV
PKS
RYQ
M
A
AI
L
SQMEI
K
D
M
F
FSK
R
I
F
F
Q
V
GE
N
PF
A
TQ
L
KK
I
T
GI
E
S
K
-----
-
---
D
VL
L
S
G
AISDFG
IK
DK
N
S
VAI
RDNE
S
F
K-
KK
F
I
Y
INGIPFK
V
H
NIA
A
K
K
KT
N
FLDSLGL
S
S
L
Q
E
D
GGF
FIPLET
AL
R
L
S
L
S
N
EI
DS
VK
L
L
L
K
KE
A
DDS
V
L
LQ
LR
E
LL
KK
N
G
V
N
D
Y
S
V
I
S
F
ID
AK
K
I
VDNVL
D
RFSLLTN
I
M
Y
F
F
LT
VT
S
V
IT
AKS
M
SK
K
M
FQ
Y
R
S
TEFALKI
LN
G
I
N
G
-
K
I
VC
F
V
I
L
M
ES
I
I
V
A
L
F
S
L
L
M
SL
LVSFF
T
LIT
V
SNI
I
S
V
KLI
M
R
Y
DVLG
M
S
VF
I
I
VFFL
C
VY
NI
RL
S
Y
S
L
FS
fig|340184.3.peg.4486
Escherichia coli B7A (44-400/412)
L
K
-
-
--
E
S
L
Q
NI
K
EN
KS
MMYL
Y
L
FV
L
I
LSFTG
V
IITDSLI
N
SV
A
K
T
A
QS
EL
R
DE
GN
SI
I
TIN
F
HI
PKS
RYQ
M
A
VV
L
SQMEI
K
D
M
V
FSK
K
F
F
F
Q
V
GE
TP
YT
TQ
L
KK
I
T
GI
E
S
K
-----
-
---
D
VL
F
G
G
IVSKFW
IK
EK
N
S
VAI
RNNN
L
F
N-
K
R
I
I
Y
INGIPFK
A
YNIA
A
K
R
KT
T
FLDSLGL
NS
L
Q
E
D
SDF
FIPLET
AL
R
L
T
L
S
N
EI
DS
VK
L
I
L
K
KE
V
DSF
YL
LQ
L
N
D
LL
KK
N
G
V
D
D
Y
S
I
I
S
F
ID
AK
K
AVDNVL
N
RFSLLTN
I
M
Y
F
F
LT
VT
S
V
IT
AKS
M
SK
K
M
FQ
Y
R
S
TEFALKI
LN
G
I
N
G
-
K
I
VC
F
V
I
L
IES
I
I
V
A
LLS
L
L
ISL
VVSFG
I
LVT
V
SNI
I
S
V
KLM
M
R
Y
DVL
T
L
S
VF
V
I
VFFL
C
VY
NI
RL
S
Y
S
L
FS
fig|340184.6.peg.4702
Escherichia coli B7A (44-400/412)
L
K
-
-
--
E
S
L
Q
NI
K
EN
KS
MMYL
Y
L
FV
L
I
LSFTG
V
IITDSLI
N
SV
A
K
T
A
QS
EL
R
DE
GN
SI
I
TIN
F
HI
PKS
RYQ
M
A
VV
L
SQMEI
K
D
M
V
FSK
K
F
F
F
Q
V
GE
TP
YT
TQ
L
KK
I
T
GI
E
S
K
-----
-
---
D
VL
F
G
G
IVSKFW
IK
EK
N
S
VAI
RNNN
L
F
N-
K
R
I
I
Y
INGIPFK
A
YNIA
A
K
R
KT
T
FLDSLGL
NS
L
Q
E
D
SDF
FIPLET
AL
R
L
T
L
S
N
EI
DS
VK
L
I
L
K
KE
V
DSF
YL
LQ
L
N
D
LL
KK
N
G
V
D
D
Y
S
I
I
S
F
ID
AK
K
AVDNVL
N
RFSLLTN
I
M
Y
F
F
LT
VT
S
V
IT
AKS
M
SK
K
M
FQ
Y
R
S
TEFALKI
LN
G
I
N
G
-
K
I
VC
F
V
I
L
IES
I
I
V
A
LLS
L
L
ISL
VVSFG
I
LVT
V
SNI
I
S
V
KLM
M
R
Y
DVL
T
L
S
VF
V
I
VFFL
C
VY
NI
RL
S
Y
S
L
FS
Consen1
Primary consensus
MLSFNMTTLh
y
Eal
NiiENrr
flvfL
LSFtGiIitDSLI
SVs
kAeeELk
sd
ifvkf
pks
it
f
k
m
FsK
aFl
VsdTPfs
l
v
Gid
-
-----
k
n
y
G
--
N
aiv
pf
kk
ifINgiPFk
igvr
n
kT
FLDSLGLka
q
d
FIPLET
klkL
n
navki
ld
v
di
vk
lL
n
i
df
I
s
lnAKeaVdnVl
RFSLlTN
vY
iLT
a
it
lskr
Fq
R
tEfaLKIihGt
k
-
k
it
lIiiEslIm
svcL
iSl
i
i
ldv
iR
tmit
sla
v
c
nI
sr
ffsinPvnaIKgkiE
Consen2
Secondary consensus
k
-
sf
lk
ks
yffv
i
v
tv
a
t
qs
r
gn
vtinl
hlt
l
e
l
-
f
f
ge
yt
v
i
v
s
qikkw
-
d
f
ik
vai
li
qr
ly
sv
n
ynia
k
i
ns
d
h
r
t
h
dsiel
tk
i
yl
n
v
h
v
ky
t
id
kt
rr
m
v
m
f
s
vv
crk
y
v
ls
ln
i
gns
vc
v
l
-
ti
v
lls
t
v
l
i
s
dvlg
avf
i
i
s
gy
llnkd
idi
hrm
Consensus 1
(when a gap)
Conservative difference
Consensus 2
(when a gap)
Nonconservative diff.
Other character