fig|344601.3.peg.181
Escherichia coli B171 (25-168/168)
MNRTILVP
I
D
I
SDS
E
-----
L
T
Q
R
V
I
S
H
-
V
E
AE
A
K
I
DD
A
EVH
F
L
T
V
I
P
SL
P
YY
ASL
G
L
-A
Y
S
A
E
L
PAM
D
D
-
L
K
A
EA
KSQ
L
E
E
I
IK
KF
K
L
PT
D
R
VHV
HVE
E
GSP
K
D
R
I
L
E
M
A
K
K
I
P
A
H
M
II
I
A
S
-
H
RP
D
I
T
T
Y
LLGSNA
AA
V
V
RHA
E
C
S
VLVVR
fig|340184.3.peg.185
Escherichia coli B7A (25-168/168)
MNRTILVP
I
D
I
SDS
E
-----
L
T
Q
R
V
I
S
H
-
V
E
AE
A
K
I
DD
A
EVH
F
L
T
V
I
P
SL
P
YY
ASL
G
L
-A
Y
S
A
E
L
PAM
D
D
-
L
K
A
EA
KSQ
L
E
E
I
IK
KF
K
L
PT
D
R
VHV
HVE
E
GSP
K
D
R
I
L
E
M
A
K
K
I
P
A
H
M
II
I
A
S
-
H
RP
D
I
T
T
Y
LLGSNA
AA
V
V
RHA
E
C
S
VLVVR
fig|340186.3.peg.266
Escherichia coli E110019 (25-168/168)
MNRTILVP
I
D
I
SDS
E
-----
L
T
Q
R
V
I
S
H
-
V
E
AE
A
K
I
DD
A
EVH
F
L
T
V
I
P
SL
P
YY
ASL
G
L
-A
Y
S
A
E
L
PAM
D
D
-
L
K
A
EA
KSQ
L
E
E
I
IK
KF
K
L
PT
D
R
VHV
HVE
E
GSP
K
D
R
I
L
E
M
A
K
K
I
P
A
H
M
II
I
A
S
-
H
RP
D
I
T
T
Y
LLGSNA
AA
V
V
RHA
E
C
S
VLVVR
fig|340185.3.peg.1011
Escherichia coli E22 (25-168/168)
MNRTILVP
I
D
I
SDS
E
-----
L
T
Q
R
V
I
S
H
-
V
E
AE
A
K
I
DD
A
EVH
F
L
T
V
I
P
SL
P
YY
ASL
G
L
-A
Y
S
A
E
L
PAM
D
D
-
L
K
A
EA
KSQ
L
E
E
I
IK
KF
K
L
PT
D
R
VHV
HVE
E
GSP
K
D
R
I
L
E
M
A
K
K
I
P
A
H
M
II
I
A
S
-
H
RP
D
I
T
T
Y
LLGSNA
AA
V
V
RHA
E
C
S
VLVVR
fig|331111.3.peg.4005
Escherichia coli E24377A (25-168/168)
MNRTILVP
I
D
I
SDS
E
-----
L
T
Q
R
V
I
S
H
-
V
E
AE
A
K
I
DD
A
EVH
F
L
T
V
I
P
SL
P
YY
ASL
G
L
-A
Y
S
A
E
L
PAM
D
D
-
L
K
A
EA
KSQ
L
E
E
I
IK
KF
K
L
PT
D
R
VHV
HVE
E
GSP
K
D
R
I
L
E
M
A
K
K
I
P
A
H
M
II
I
A
S
-
H
RP
D
I
T
T
Y
LLGSNA
AA
V
V
RHA
E
C
S
VLVVR
fig|216592.1.peg.1919
Escherichia coli 042 (25-168/168)
MNRTILVP
I
D
I
SDS
E
-----
L
T
Q
R
V
I
S
H
-
V
E
AE
A
K
I
DD
A
EVH
F
L
T
V
I
P
SL
P
YY
ASL
G
L
-A
Y
S
A
E
L
PAM
D
D
-
L
K
A
EA
KSQ
L
E
E
I
IK
KF
K
L
PT
D
R
VHV
HVE
E
GSP
K
D
R
I
L
ELA
K
K
I
P
A
H
M
II
I
A
S
-
H
RP
D
I
T
T
Y
LLGSNA
AA
V
V
RHA
E
C
S
VLVVR
fig|199310.1.peg.1766
Escherichia coli CFT073 (25-168/168)
MNRTILVP
I
D
I
SDS
E
-----
L
T
Q
R
V
I
S
H
-
V
E
AE
A
K
I
DD
A
EVH
F
L
T
V
I
P
SL
P
YY
ASL
G
L
-A
Y
S
A
E
L
PAM
D
D
-
L
K
A
EA
KSQ
L
E
E
I
IK
KF
K
L
PT
D
R
VHV
HVE
E
GSP
K
D
R
I
L
ELA
K
K
I
P
A
H
M
II
I
A
S
-
H
RP
D
I
T
T
Y
LLGSNA
AA
V
V
RHA
E
C
S
VLVVR
fig|216593.1.peg.1992
Escherichia coli E2348/69 (25-168/168)
MNRTILVP
I
D
I
SDS
E
-----
L
T
Q
R
V
I
S
H
-
V
E
AE
A
K
I
DD
A
EVH
F
L
T
V
I
P
SL
P
YY
ASL
G
L
-A
Y
S
A
E
L
PAM
D
D
-
L
K
A
EA
KSQ
L
E
E
I
IK
KF
K
L
PT
D
R
VHV
HVE
E
GSP
K
D
R
I
L
ELA
K
K
I
P
A
H
M
II
I
A
S
-
H
RP
D
I
T
T
Y
LLGSNA
AA
V
V
RHA
E
C
S
VLVVR
fig|340197.3.peg.1177
Escherichia coli F11 (25-168/168)
MNRTILVP
I
D
I
SDS
E
-----
L
T
Q
R
V
I
S
H
-
V
E
AE
A
K
I
DD
A
EVH
F
L
T
V
I
P
SL
P
YY
ASL
G
L
-A
Y
S
A
E
L
PAM
D
D
-
L
K
A
EA
KSQ
L
E
E
I
IK
KF
K
L
PT
D
R
VHV
HVE
E
GSP
K
D
R
I
L
ELA
K
K
I
P
A
H
M
II
I
A
S
-
H
RP
D
I
T
T
Y
LLGSNA
AA
V
V
RHA
E
C
S
VLVVR
fig|155864.1.peg.2079
Escherichia coli O157:H7 EDL933 (25-168/168)
MNRTILVP
I
D
I
SDS
E
-----
L
T
Q
R
V
I
S
H
-
V
E
AE
A
K
I
DD
A
EVH
F
L
T
V
I
P
SL
P
YY
ASL
G
L
-A
Y
S
A
E
L
PAM
D
D
-
L
K
A
EA
KSQ
L
E
E
I
IK
KF
K
L
PT
D
R
VHV
HVE
E
GSP
K
D
R
I
L
ELA
K
K
I
P
A
H
M
II
I
A
S
-
H
RP
D
I
T
T
Y
LLGSNA
AA
V
V
RHA
E
C
S
VLVVR
fig|344610.3.peg.1126
Escherichia coli 53638 (25-168/168)
MNRTILVP
I
D
I
SDS
E
-----
L
T
Q
R
V
I
S
H
-
V
E
EE
A
K
I
DD
A
EVH
F
L
T
V
I
P
SL
P
YY
ASL
G
L
-A
Y
S
A
E
L
PAM
D
D
-
L
K
A
EA
KSQ
L
E
E
I
IK
KF
K
L
PT
D
R
VHV
HVE
E
GSP
K
D
R
I
L
ELA
K
K
I
P
A
H
M
II
I
A
S
-
H
RP
D
I
T
T
Y
LLGSNA
AA
V
V
RHA
E
C
S
VLVVR
fig|481805.3.peg.2446
Escherichia coli ATCC 8739 (25-168/168)
MNRTILVP
I
D
I
SDS
E
-----
L
T
Q
R
V
I
S
H
-
V
E
EE
A
K
I
DD
A
EVH
F
L
T
V
I
P
SL
P
YY
ASL
G
L
-A
Y
S
A
E
L
PAM
D
D
-
L
K
A
EA
KSQ
L
E
E
I
IK
KF
K
L
PT
D
R
VHV
HVE
E
GSP
K
D
R
I
L
ELA
K
K
I
P
A
H
M
II
I
A
S
-
H
RP
D
I
T
T
Y
LLGSNA
AA
V
V
RHA
E
C
S
VLVVR
fig|331112.3.peg.1371
Escherichia coli HS (25-168/168)
MNRTILVP
I
D
I
SDS
E
-----
L
T
Q
R
V
I
S
H
-
V
E
EE
A
K
I
DD
A
EVH
F
L
T
V
I
P
SL
P
YY
ASL
G
L
-A
Y
S
A
E
L
PAM
D
D
-
L
K
A
EA
KSQ
L
E
E
I
IK
KF
K
L
PT
D
R
VHV
HVE
E
GSP
K
D
R
I
L
ELA
K
K
I
P
A
H
M
II
I
A
S
-
H
RP
D
I
T
T
Y
LLGSNA
AA
V
V
RHA
E
C
S
VLVVR
fig|1040638.4.peg.4112
Escherichia coli O104:H4 str. LB226692
MNRTILVP
I
D
I
SDS
E
-----
L
T
Q
R
V
I
S
H
-
V
E
AE
A
K
I
DD
A
EVH
F
L
T
V
I
P
SL
P
YY
ASL
G
L
-A
Y
S
A
E
L
PAM
D
D
-
L
K
A
EA
KSQ
L
E
E
I
IK
KF
K
L
PT
D
R
VHV
HVE
E
GSP
K
D
R
I
L
E
M
A
K
K
I
P
A
H
M
II
I
A
S
-
H
RP
D
I
T
T
Y
LLGSNA
AA
V
V
RHA
E
C
S
VLVVR
fig|6666666.5357.peg.1328
Escherichia coli TY-2482
MNRTILVP
I
D
I
SDS
E
-----
L
T
Q
R
V
I
S
H
-
V
E
AE
A
K
I
DD
A
EVH
F
L
T
V
I
P
SL
P
YY
ASL
G
L
-A
Y
S
A
E
L
PAM
D
D
-
L
K
A
EA
KSQ
L
E
E
I
IK
KF
K
L
PT
D
R
VHV
HVE
E
GSP
K
D
R
I
L
E
M
A
K
K
I
P
A
H
M
II
I
A
S
-
H
RP
D
I
T
T
Y
LLGSNA
AA
V
V
RHA
E
C
S
VLVVR
fig|585055.6.peg.1541
Escherichia coli 55989
MNRTILVP
I
D
I
SDS
E
-----
L
T
Q
R
V
I
S
H
-
V
E
AE
A
K
I
DD
A
EVH
F
L
T
V
I
P
SL
P
YY
ASL
G
L
-A
Y
S
A
E
L
PAM
D
D
-
L
K
A
EA
KSQ
L
E
E
I
IK
KF
K
L
PT
D
R
VHV
HVE
E
GSP
K
D
R
I
L
E
M
A
K
K
I
P
A
H
M
II
I
A
S
-
H
RP
D
I
T
T
Y
LLGSNA
AA
V
V
RHA
E
C
S
VLVVR
fig|585055.8.peg.1542
Escherichia coli 55989
MNRTILVP
I
D
I
SDS
E
-----
L
T
Q
R
V
I
S
H
-
V
E
AE
A
K
I
DD
A
EVH
F
L
T
V
I
P
SL
P
YY
ASL
G
L
-A
Y
S
A
E
L
PAM
D
D
-
L
K
A
EA
KSQ
L
E
E
I
IK
KF
K
L
PT
D
R
VHV
HVE
E
GSP
K
D
R
I
L
E
M
A
K
K
I
P
A
H
M
II
I
A
S
-
H
RP
D
I
T
T
Y
LLGSNA
AA
V
V
RHA
E
C
S
VLVVR
fig|344601.5.peg.178
Escherichia coli B171
MNRTILVP
I
D
I
SDS
E
-----
L
T
Q
R
V
I
S
H
-
V
E
AE
A
K
I
DD
A
EVH
F
L
T
V
I
P
SL
P
YY
ASL
G
L
-A
Y
S
A
E
L
PAM
D
D
-
L
K
A
EA
KSQ
L
E
E
I
IK
KF
K
L
PT
D
R
VHV
HVE
E
GSP
K
D
R
I
L
E
M
A
K
K
I
P
A
H
M
II
I
A
S
-
H
RP
D
I
T
T
Y
LLGSNA
AA
V
V
RHA
E
C
S
VLVVR
fig|340184.6.peg.191
Escherichia coli B7A
MNRTILVP
I
D
I
SDS
E
-----
L
T
Q
R
V
I
S
H
-
V
E
AE
A
K
I
DD
A
EVH
F
L
T
V
I
P
SL
P
YY
ASL
G
L
-A
Y
S
A
E
L
PAM
D
D
-
L
K
A
EA
KSQ
L
E
E
I
IK
KF
K
L
PT
D
R
VHV
HVE
E
GSP
K
D
R
I
L
E
M
A
K
K
I
P
A
H
M
II
I
A
S
-
H
RP
D
I
T
T
Y
LLGSNA
AA
V
V
RHA
E
C
S
VLVVR
fig|340186.5.peg.282
Escherichia coli E110019
MNRTILVP
I
D
I
SDS
E
-----
L
T
Q
R
V
I
S
H
-
V
E
AE
A
K
I
DD
A
EVH
F
L
T
V
I
P
SL
P
YY
ASL
G
L
-A
Y
S
A
E
L
PAM
D
D
-
L
K
A
EA
KSQ
L
E
E
I
IK
KF
K
L
PT
D
R
VHV
HVE
E
GSP
K
D
R
I
L
E
M
A
K
K
I
P
A
H
M
II
I
A
S
-
H
RP
D
I
T
T
Y
LLGSNA
AA
V
V
RHA
E
C
S
VLVVR
fig|340185.4.peg.1062
Escherichia coli E22
MNRTILVP
I
D
I
SDS
E
-----
L
T
Q
R
V
I
S
H
-
V
E
AE
A
K
I
DD
A
EVH
F
L
T
V
I
P
SL
P
YY
ASL
G
L
-A
Y
S
A
E
L
PAM
D
D
-
L
K
A
EA
KSQ
L
E
E
I
IK
KF
K
L
PT
D
R
VHV
HVE
E
GSP
K
D
R
I
L
E
M
A
K
K
I
P
A
H
M
II
I
A
S
-
H
RP
D
I
T
T
Y
LLGSNA
AA
V
V
RHA
E
C
S
VLVVR
fig|331111.12.peg.1844
Escherichia coli E24377A
MNRTILVP
I
D
I
SDS
E
-----
L
T
Q
R
V
I
S
H
-
V
E
AE
A
K
I
DD
A
EVH
F
L
T
V
I
P
SL
P
YY
ASL
G
L
-A
Y
S
A
E
L
PAM
D
D
-
L
K
A
EA
KSQ
L
E
E
I
IK
KF
K
L
PT
D
R
VHV
HVE
E
GSP
K
D
R
I
L
E
M
A
K
K
I
P
A
H
M
II
I
A
S
-
H
RP
D
I
T
T
Y
LLGSNA
AA
V
V
RHA
E
C
S
VLVVR
fig|562.375.peg.4256
Escherichia coli EC4100B
MNRTILVP
I
D
I
SDS
E
-----
L
T
Q
R
V
I
S
H
-
V
E
AE
A
K
I
DD
A
EVH
F
L
T
V
I
P
SL
P
YY
ASL
G
L
-A
Y
S
A
E
L
PAM
D
D
-
L
K
A
EA
KSQ
L
E
E
I
IK
KF
K
L
PT
D
R
VHV
HVE
E
GSP
K
D
R
I
L
E
M
A
K
K
I
P
A
H
M
II
I
A
S
-
H
RP
D
I
T
T
Y
LLGSNA
AA
V
V
RHA
E
C
S
VLVVR
fig|656408.3.peg.1507
Escherichia coli H591
MNRTILVP
I
D
I
SDS
E
-----
L
T
Q
R
V
I
S
H
-
V
E
AE
A
K
I
DD
A
EVH
F
L
T
V
I
P
SL
P
YY
ASL
G
L
-A
Y
S
A
E
L
PAM
D
D
-
L
K
A
EA
KSQ
L
E
E
I
IK
KF
K
L
PT
D
R
VHV
HVE
E
GSP
K
D
R
I
L
E
M
A
K
K
I
P
A
H
M
II
I
A
S
-
H
RP
D
I
T
T
Y
LLGSNA
AA
V
V
RHA
E
C
S
VLVVR
fig|585034.4.peg.1365
Escherichia coli IAI1
MNRTILVP
I
D
I
SDS
E
-----
L
T
Q
R
V
I
S
H
-
V
E
AE
A
K
I
DD
A
EVH
F
L
T
V
I
P
SL
P
YY
ASL
G
L
-A
Y
S
A
E
L
PAM
D
D
-
L
K
A
EA
KSQ
L
E
E
I
IK
KF
K
L
PT
D
R
VHV
HVE
E
GSP
K
D
R
I
L
E
M
A
K
K
I
P
A
H
M
II
I
A
S
-
H
RP
D
I
T
T
Y
LLGSNA
AA
V
V
RHA
E
C
S
VLVVR
fig|585034.5.peg.1361
Escherichia coli IAI1
MNRTILVP
I
D
I
SDS
E
-----
L
T
Q
R
V
I
S
H
-
V
E
AE
A
K
I
DD
A
EVH
F
L
T
V
I
P
SL
P
YY
ASL
G
L
-A
Y
S
A
E
L
PAM
D
D
-
L
K
A
EA
KSQ
L
E
E
I
IK
KF
K
L
PT
D
R
VHV
HVE
E
GSP
K
D
R
I
L
E
M
A
K
K
I
P
A
H
M
II
I
A
S
-
H
RP
D
I
T
T
Y
LLGSNA
AA
V
V
RHA
E
C
S
VLVVR
fig|595495.4.peg.970
Escherichia coli KO11
MNRTILVP
I
D
I
SDS
E
-----
L
T
Q
R
V
I
S
H
-
V
E
AE
A
K
I
DD
A
EVH
F
L
T
V
I
P
SL
P
YY
ASL
G
L
-A
Y
S
A
E
L
PAM
D
D
-
L
K
A
EA
KSQ
L
E
E
I
IK
KF
K
L
PT
D
R
VHV
HVE
E
GSP
K
D
R
I
L
E
M
A
K
K
I
P
A
H
M
II
I
A
S
-
H
RP
D
I
T
T
Y
LLGSNA
AA
V
V
RHA
E
C
S
VLVVR
fig|679207.4.peg.4989
Escherichia coli MS 107-1
MNRTILVP
I
D
I
SDS
E
-----
L
T
Q
R
V
I
S
H
-
V
E
AE
A
K
I
DD
A
EVH
F
L
T
V
I
P
SL
P
YY
ASL
G
L
-A
Y
S
A
E
L
PAM
D
D
-
L
K
A
EA
KSQ
L
E
E
I
IK
KF
K
L
PT
D
R
VHV
HVE
E
GSP
K
D
R
I
L
E
M
A
K
K
I
P
A
H
M
II
I
A
S
-
H
RP
D
I
T
T
Y
LLGSNA
AA
V
V
RHA
E
C
S
VLVVR
fig|749537.3.peg.462
Escherichia coli MS 115-1
MNRTILVP
I
D
I
SDS
E
-----
L
T
Q
R
V
I
S
H
-
V
E
AE
A
K
I
DD
A
EVH
F
L
T
V
I
P
SL
P
YY
ASL
G
L
-A
Y
S
A
E
L
PAM
D
D
-
L
K
A
EA
KSQ
L
E
E
I
IK
KF
K
L
PT
D
R
VHV
HVE
E
GSP
K
D
R
I
L
E
M
A
K
K
I
P
A
H
M
II
I
A
S
-
H
RP
D
I
T
T
Y
LLGSNA
AA
V
V
RHA
E
C
S
VLVVR
fig|679204.3.peg.4180
Escherichia coli MS 145-7
MNRTILVP
I
D
I
SDS
E
-----
L
T
Q
R
V
I
S
H
-
V
E
AE
A
K
I
DD
A
EVH
F
L
T
V
I
P
SL
P
YY
ASL
G
L
-A
Y
S
A
E
L
PAM
D
D
-
L
K
A
EA
KSQ
L
E
E
I
IK
KF
K
L
PT
D
R
VHV
HVE
E
GSP
K
D
R
I
L
E
M
A
K
K
I
P
A
H
M
II
I
A
S
-
H
RP
D
I
T
T
Y
LLGSNA
AA
V
V
RHA
E
C
S
VLVVR
fig|749545.3.peg.1146
Escherichia coli MS 182-1
MNRTILVP
I
D
I
SDS
E
-----
L
T
Q
R
V
I
S
H
-
V
E
AE
A
K
I
DD
A
EVH
F
L
T
V
I
P
SL
P
YY
ASL
G
L
-A
Y
S
A
E
L
PAM
D
D
-
L
K
A
EA
KSQ
L
E
E
I
IK
KF
K
L
PT
D
R
VHV
HVE
E
GSP
K
D
R
I
L
E
M
A
K
K
I
P
A
H
M
II
I
A
S
-
H
RP
D
I
T
T
Y
LLGSNA
AA
V
V
RHA
E
C
S
VLVVR
fig|749532.3.peg.1744
Escherichia coli MS 78-1
MNRTILVP
I
D
I
SDS
E
-----
L
T
Q
R
V
I
S
H
-
V
E
AE
A
K
I
DD
A
EVH
F
L
T
V
I
P
SL
P
YY
ASL
G
L
-A
Y
S
A
E
L
PAM
D
D
-
L
K
A
EA
KSQ
L
E
E
I
IK
KF
K
L
PT
D
R
VHV
HVE
E
GSP
K
D
R
I
L
E
M
A
K
K
I
P
A
H
M
II
I
A
S
-
H
RP
D
I
T
T
Y
LLGSNA
AA
V
V
RHA
E
C
S
VLVVR
fig|585395.4.peg.1586
Escherichia coli O103:H2 str. 12009
MNRTILVP
I
D
I
SDS
E
-----
L
T
Q
R
V
I
S
H
-
V
E
AE
A
K
I
DD
A
EVH
F
L
T
V
I
P
SL
P
YY
ASL
G
L
-A
Y
S
A
E
L
PAM
D
D
-
L
K
A
EA
KSQ
L
E
E
I
IK
KF
K
L
PT
D
R
VHV
HVE
E
GSP
K
D
R
I
L
E
M
A
K
K
I
P
A
H
M
II
I
A
S
-
H
RP
D
I
T
T
Y
LLGSNA
AA
V
V
RHA
E
C
S
VLVVR
fig|409438.11.peg.1602
Escherichia coli SE11
MNRTILVP
I
D
I
SDS
E
-----
L
T
Q
R
V
I
S
H
-
V
E
AE
A
K
I
DD
A
EVH
F
L
T
V
I
P
SL
P
YY
ASL
G
L
-A
Y
S
A
E
L
PAM
D
D
-
L
K
A
EA
KSQ
L
E
E
I
IK
KF
K
L
PT
D
R
VHV
HVE
E
GSP
K
D
R
I
L
E
M
A
K
K
I
P
A
H
M
II
I
A
S
-
H
RP
D
I
T
T
Y
LLGSNA
AA
V
V
RHA
E
C
S
VLVVR
fig|656443.3.peg.1695
Escherichia coli TA271
MNRTILVP
I
D
I
SDS
E
-----
L
T
Q
R
V
I
S
H
-
V
E
AE
A
K
I
DD
A
EVH
F
L
T
V
I
P
SL
P
YY
ASL
G
L
-A
Y
S
A
E
L
PAM
D
D
-
L
K
A
EA
KSQ
L
E
E
I
IK
KF
K
L
PT
D
R
VHV
HVE
E
GSP
K
D
R
I
L
E
M
A
K
K
I
P
A
H
M
II
I
A
S
-
H
RP
D
I
T
T
Y
LLGSNA
AA
V
V
RHA
E
C
S
VLVVR
fig|566546.3.peg.87
Escherichia coli W
MNRTILVP
I
D
I
SDS
E
-----
L
T
Q
R
V
I
S
H
-
V
E
AE
A
K
I
DD
A
EVH
F
L
T
V
I
P
SL
P
YY
ASL
G
L
-A
Y
S
A
E
L
PAM
D
D
-
L
K
A
EA
KSQ
L
E
E
I
IK
KF
K
L
PT
D
R
VHV
HVE
E
GSP
K
D
R
I
L
E
M
A
K
K
I
P
A
H
M
II
I
A
S
-
H
RP
D
I
T
T
Y
LLGSNA
AA
V
V
RHA
E
C
S
VLVVR
fig|566546.4.peg.1495
Escherichia coli W
MNRTILVP
I
D
I
SDS
E
-----
L
T
Q
R
V
I
S
H
-
V
E
AE
A
K
I
DD
A
EVH
F
L
T
V
I
P
SL
P
YY
ASL
G
L
-A
Y
S
A
E
L
PAM
D
D
-
L
K
A
EA
KSQ
L
E
E
I
IK
KF
K
L
PT
D
R
VHV
HVE
E
GSP
K
D
R
I
L
E
M
A
K
K
I
P
A
H
M
II
I
A
S
-
H
RP
D
I
T
T
Y
LLGSNA
AA
V
V
RHA
E
C
S
VLVVR
fig|216592.3.peg.1577
Escherichia coli 042
MNRTILVP
I
D
I
SDS
E
-----
L
T
Q
R
V
I
S
H
-
V
E
AE
A
K
I
DD
A
EVH
F
L
T
V
I
P
SL
P
YY
ASL
G
L
-A
Y
S
A
E
L
PAM
D
D
-
L
K
A
EA
KSQ
L
E
E
I
IK
KF
K
L
PT
D
R
VHV
HVE
E
GSP
K
D
R
I
L
ELA
K
K
I
P
A
H
M
II
I
A
S
-
H
RP
D
I
T
T
Y
LLGSNA
AA
V
V
RHA
E
C
S
VLVVR
fig|562.371.peg.1824
Escherichia coli 1044A
MNRTILVP
I
D
I
SDS
E
-----
L
T
Q
R
V
I
S
H
-
V
E
AE
A
K
I
DD
A
EVH
F
L
T
V
I
P
SL
P
YY
ASL
G
L
-A
Y
S
A
E
L
PAM
D
D
-
L
K
A
EA
KSQ
L
E
E
I
IK
KF
K
L
PT
D
R
VHV
HVE
E
GSP
K
D
R
I
L
ELA
K
K
I
P
A
H
M
II
I
A
S
-
H
RP
D
I
T
T
Y
LLGSNA
AA
V
V
RHA
E
C
S
VLVVR
fig|562.373.peg.5171
Escherichia coli 1125A
MNRTILVP
I
D
I
SDS
E
-----
L
T
Q
R
V
I
S
H
-
V
E
AE
A
K
I
DD
A
EVH
F
L
T
V
I
P
SL
P
YY
ASL
G
L
-A
Y
S
A
E
L
PAM
D
D
-
L
K
A
EA
KSQ
L
E
E
I
IK
KF
K
L
PT
D
R
VHV
HVE
E
GSP
K
D
R
I
L
ELA
K
K
I
P
A
H
M
II
I
A
S
-
H
RP
D
I
T
T
Y
LLGSNA
AA
V
V
RHA
E
C
S
VLVVR
fig|562.372.peg.1309
Escherichia coli 1212A
MNRTILVP
I
D
I
SDS
E
-----
L
T
Q
R
V
I
S
H
-
V
E
AE
A
K
I
DD
A
EVH
F
L
T
V
I
P
SL
P
YY
ASL
G
L
-A
Y
S
A
E
L
PAM
D
D
-
L
K
A
EA
KSQ
L
E
E
I
IK
KF
K
L
PT
D
R
VHV
HVE
E
GSP
K
D
R
I
L
ELA
K
K
I
P
A
H
M
II
I
A
S
-
H
RP
D
I
T
T
Y
LLGSNA
AA
V
V
RHA
E
C
S
VLVVR
fig|670897.3.peg.2404
Escherichia coli 2362-75
MNRTILVP
I
D
I
SDS
E
-----
L
T
Q
R
V
I
S
H
-
V
E
AE
A
K
I
DD
A
EVH
F
L
T
V
I
P
SL
P
YY
ASL
G
L
-A
Y
S
A
E
L
PAM
D
D
-
L
K
A
EA
KSQ
L
E
E
I
IK
KF
K
L
PT
D
R
VHV
HVE
E
GSP
K
D
R
I
L
ELA
K
K
I
P
A
H
M
II
I
A
S
-
H
RP
D
I
T
T
Y
LLGSNA
AA
V
V
RHA
E
C
S
VLVVR
fig|362663.8.peg.1412
Escherichia coli 536
MNRTILVP
I
D
I
SDS
E
-----
L
T
Q
R
V
I
S
H
-
V
E
AE
A
K
I
DD
A
EVH
F
L
T
V
I
P
SL
P
YY
ASL
G
L
-A
Y
S
A
E
L
PAM
D
D
-
L
K
A
EA
KSQ
L
E
E
I
IK
KF
K
L
PT
D
R
VHV
HVE
E
GSP
K
D
R
I
L
ELA
K
K
I
P
A
H
M
II
I
A
S
-
H
RP
D
I
T
T
Y
LLGSNA
AA
V
V
RHA
E
C
S
VLVVR
fig|362663.9.peg.1414
Escherichia coli 536
MNRTILVP
I
D
I
SDS
E
-----
L
T
Q
R
V
I
S
H
-
V
E
AE
A
K
I
DD
A
EVH
F
L
T
V
I
P
SL
P
YY
ASL
G
L
-A
Y
S
A
E
L
PAM
D
D
-
L
K
A
EA
KSQ
L
E
E
I
IK
KF
K
L
PT
D
R
VHV
HVE
E
GSP
K
D
R
I
L
ELA
K
K
I
P
A
H
M
II
I
A
S
-
H
RP
D
I
T
T
Y
LLGSNA
AA
V
V
RHA
E
C
S
VLVVR
fig|562.374.peg.2277
Escherichia coli 536A
MNRTILVP
I
D
I
SDS
E
-----
L
T
Q
R
V
I
S
H
-
V
E
AE
A
K
I
DD
A
EVH
F
L
T
V
I
P
SL
P
YY
ASL
G
L
-A
Y
S
A
E
L
PAM
D
D
-
L
K
A
EA
KSQ
L
E
E
I
IK
KF
K
L
PT
D
R
VHV
HVE
E
GSP
K
D
R
I
L
ELA
K
K
I
P
A
H
M
II
I
A
S
-
H
RP
D
I
T
T
Y
LLGSNA
AA
V
V
RHA
E
C
S
VLVVR
fig|525281.3.peg.72
Escherichia coli 83972
MNRTILVP
I
D
I
SDS
E
-----
L
T
Q
R
V
I
S
H
-
V
E
AE
A
K
I
DD
A
EVH
F
L
T
V
I
P
SL
P
YY
ASL
G
L
-A
Y
S
A
E
L
PAM
D
D
-
L
K
A
EA
KSQ
L
E
E
I
IK
KF
K
L
PT
D
R
VHV
HVE
E
GSP
K
D
R
I
L
ELA
K
K
I
P
A
H
M
II
I
A
S
-
H
RP
D
I
T
T
Y
LLGSNA
AA
V
V
RHA
E
C
S
VLVVR
fig|655817.3.peg.1710
Escherichia coli ABU 83972
MNRTILVP
I
D
I
SDS
E
-----
L
T
Q
R
V
I
S
H
-
V
E
AE
A
K
I
DD
A
EVH
F
L
T
V
I
P
SL
P
YY
ASL
G
L
-A
Y
S
A
E
L
PAM
D
D
-
L
K
A
EA
KSQ
L
E
E
I
IK
KF
K
L
PT
D
R
VHV
HVE
E
GSP
K
D
R
I
L
ELA
K
K
I
P
A
H
M
II
I
A
S
-
H
RP
D
I
T
T
Y
LLGSNA
AA
V
V
RHA
E
C
S
VLVVR
fig|405955.13.peg.1522
Escherichia coli APEC O1
MNRTILVP
I
D
I
SDS
E
-----
L
T
Q
R
V
I
S
H
-
V
E
AE
A
K
I
DD
A
EVH
F
L
T
V
I
P
SL
P
YY
ASL
G
L
-A
Y
S
A
E
L
PAM
D
D
-
L
K
A
EA
KSQ
L
E
E
I
IK
KF
K
L
PT
D
R
VHV
HVE
E
GSP
K
D
R
I
L
ELA
K
K
I
P
A
H
M
II
I
A
S
-
H
RP
D
I
T
T
Y
LLGSNA
AA
V
V
RHA
E
C
S
VLVVR
fig|405955.9.peg.1246
Escherichia coli APEC O1
MNRTILVP
I
D
I
SDS
E
-----
L
T
Q
R
V
I
S
H
-
V
E
AE
A
K
I
DD
A
EVH
F
L
T
V
I
P
SL
P
YY
ASL
G
L
-A
Y
S
A
E
L
PAM
D
D
-
L
K
A
EA
KSQ
L
E
E
I
IK
KF
K
L
PT
D
R
VHV
HVE
E
GSP
K
D
R
I
L
ELA
K
K
I
P
A
H
M
II
I
A
S
-
H
RP
D
I
T
T
Y
LLGSNA
AA
V
V
RHA
E
C
S
VLVVR
fig|550676.3.peg.961
Escherichia coli B185
MNRTILVP
I
D
I
SDS
E
-----
L
T
Q
R
V
I
S
H
-
V
E
AE
A
K
I
DD
A
EVH
F
L
T
V
I
P
SL
P
YY
ASL
G
L
-A
Y
S
A
E
L
PAM
D
D
-
L
K
A
EA
KSQ
L
E
E
I
IK
KF
K
L
PT
D
R
VHV
HVE
E
GSP
K
D
R
I
L
ELA
K
K
I
P
A
H
M
II
I
A
S
-
H
RP
D
I
T
T
Y
LLGSNA
AA
V
V
RHA
E
C
S
VLVVR
fig|550677.3.peg.2806
Escherichia coli B354
MNRTILVP
I
D
I
SDS
E
-----
L
T
Q
R
V
I
S
H
-
V
E
AE
A
K
I
DD
A
EVH
F
L
T
V
I
P
SL
P
YY
ASL
G
L
-A
Y
S
A
E
L
PAM
D
D
-
L
K
A
EA
KSQ
L
E
E
I
IK
KF
K
L
PT
D
R
VHV
HVE
E
GSP
K
D
R
I
L
ELA
K
K
I
P
A
H
M
II
I
A
S
-
H
RP
D
I
T
T
Y
LLGSNA
AA
V
V
RHA
E
C
S
VLVVR
fig|199310.4.peg.1697
Escherichia coli CFT073
MNRTILVP
I
D
I
SDS
E
-----
L
T
Q
R
V
I
S
H
-
V
E
AE
A
K
I
DD
A
EVH
F
L
T
V
I
P
SL
P
YY
ASL
G
L
-A
Y
S
A
E
L
PAM
D
D
-
L
K
A
EA
KSQ
L
E
E
I
IK
KF
K
L
PT
D
R
VHV
HVE
E
GSP
K
D
R
I
L
ELA
K
K
I
P
A
H
M
II
I
A
S
-
H
RP
D
I
T
T
Y
LLGSNA
AA
V
V
RHA
E
C
S
VLVVR
fig|585397.7.peg.1566
Escherichia coli ED1a
MNRTILVP
I
D
I
SDS
E
-----
L
T
Q
R
V
I
S
H
-
V
E
AE
A
K
I
DD
A
EVH
F
L
T
V
I
P
SL
P
YY
ASL
G
L
-A
Y
S
A
E
L
PAM
D
D
-
L
K
A
EA
KSQ
L
E
E
I
IK
KF
K
L
PT
D
R
VHV
HVE
E
GSP
K
D
R
I
L
ELA
K
K
I
P
A
H
M
II
I
A
S
-
H
RP
D
I
T
T
Y
LLGSNA
AA
V
V
RHA
E
C
S
VLVVR
fig|585397.9.peg.1560
Escherichia coli ED1a
MNRTILVP
I
D
I
SDS
E
-----
L
T
Q
R
V
I
S
H
-
V
E
AE
A
K
I
DD
A
EVH
F
L
T
V
I
P
SL
P
YY
ASL
G
L
-A
Y
S
A
E
L
PAM
D
D
-
L
K
A
EA
KSQ
L
E
E
I
IK
KF
K
L
PT
D
R
VHV
HVE
E
GSP
K
D
R
I
L
ELA
K
K
I
P
A
H
M
II
I
A
S
-
H
RP
D
I
T
T
Y
LLGSNA
AA
V
V
RHA
E
C
S
VLVVR
fig|340197.5.peg.1239
Escherichia coli F11
MNRTILVP
I
D
I
SDS
E
-----
L
T
Q
R
V
I
S
H
-
V
E
AE
A
K
I
DD
A
EVH
F
L
T
V
I
P
SL
P
YY
ASL
G
L
-A
Y
S
A
E
L
PAM
D
D
-
L
K
A
EA
KSQ
L
E
E
I
IK
KF
K
L
PT
D
R
VHV
HVE
E
GSP
K
D
R
I
L
ELA
K
K
I
P
A
H
M
II
I
A
S
-
H
RP
D
I
T
T
Y
LLGSNA
AA
V
V
RHA
E
C
S
VLVVR
fig|656379.3.peg.3431
Escherichia coli FVEC1302
MNRTILVP
I
D
I
SDS
E
-----
L
T
Q
R
V
I
S
H
-
V
E
AE
A
K
I
DD
A
EVH
F
L
T
V
I
P
SL
P
YY
ASL
G
L
-A
Y
S
A
E
L
PAM
D
D
-
L
K
A
EA
KSQ
L
E
E
I
IK
KF
K
L
PT
D
R
VHV
HVE
E
GSP
K
D
R
I
L
ELA
K
K
I
P
A
H
M
II
I
A
S
-
H
RP
D
I
T
T
Y
LLGSNA
AA
V
V
RHA
E
C
S
VLVVR
fig|656380.3.peg.2784
Escherichia coli FVEC1412
MNRTILVP
I
D
I
SDS
E
-----
L
T
Q
R
V
I
S
H
-
V
E
AE
A
K
I
DD
A
EVH
F
L
T
V
I
P
SL
P
YY
ASL
G
L
-A
Y
S
A
E
L
PAM
D
D
-
L
K
A
EA
KSQ
L
E
E
I
IK
KF
K
L
PT
D
R
VHV
HVE
E
GSP
K
D
R
I
L
ELA
K
K
I
P
A
H
M
II
I
A
S
-
H
RP
D
I
T
T
Y
LLGSNA
AA
V
V
RHA
E
C
S
VLVVR
fig|656393.3.peg.2123
Escherichia coli H299
MNRTILVP
I
D
I
SDS
E
-----
L
T
Q
R
V
I
S
H
-
V
E
AE
A
K
I
DD
A
EVH
F
L
T
V
I
P
SL
P
YY
ASL
G
L
-A
Y
S
A
E
L
PAM
D
D
-
L
K
A
EA
KSQ
L
E
E
I
IK
KF
K
L
PT
D
R
VHV
HVE
E
GSP
K
D
R
I
L
ELA
K
K
I
P
A
H
M
II
I
A
S
-
H
RP
D
I
T
T
Y
LLGSNA
AA
V
V
RHA
E
C
S
VLVVR
fig|585057.4.peg.1770
Escherichia coli IAI39
MNRTILVP
I
D
I
SDS
E
-----
L
T
Q
R
V
I
S
H
-
V
E
AE
A
K
I
DD
A
EVH
F
L
T
V
I
P
SL
P
YY
ASL
G
L
-A
Y
S
A
E
L
PAM
D
D
-
L
K
A
EA
KSQ
L
E
E
I
IK
KF
K
L
PT
D
R
VHV
HVE
E
GSP
K
D
R
I
L
ELA
K
K
I
P
A
H
M
II
I
A
S
-
H
RP
D
I
T
T
Y
LLGSNA
AA
V
V
RHA
E
C
S
VLVVR
fig|585057.6.peg.1770
Escherichia coli IAI39
MNRTILVP
I
D
I
SDS
E
-----
L
T
Q
R
V
I
S
H
-
V
E
AE
A
K
I
DD
A
EVH
F
L
T
V
I
P
SL
P
YY
ASL
G
L
-A
Y
S
A
E
L
PAM
D
D
-
L
K
A
EA
KSQ
L
E
E
I
IK
KF
K
L
PT
D
R
VHV
HVE
E
GSP
K
D
R
I
L
ELA
K
K
I
P
A
H
M
II
I
A
S
-
H
RP
D
I
T
T
Y
LLGSNA
AA
V
V
RHA
E
C
S
VLVVR
fig|714962.3.peg.1589
Escherichia coli IHE3034
MNRTILVP
I
D
I
SDS
E
-----
L
T
Q
R
V
I
S
H
-
V
E
AE
A
K
I
DD
A
EVH
F
L
T
V
I
P
SL
P
YY
ASL
G
L
-A
Y
S
A
E
L
PAM
D
D
-
L
K
A
EA
KSQ
L
E
E
I
IK
KF
K
L
PT
D
R
VHV
HVE
E
GSP
K
D
R
I
L
ELA
K
K
I
P
A
H
M
II
I
A
S
-
H
RP
D
I
T
T
Y
LLGSNA
AA
V
V
RHA
E
C
S
VLVVR
fig|656417.3.peg.1664
Escherichia coli M605
MNRTILVP
I
D
I
SDS
E
-----
L
T
Q
R
V
I
S
H
-
V
E
AE
A
K
I
DD
A
EVH
F
L
T
V
I
P
SL
P
YY
ASL
G
L
-A
Y
S
A
E
L
PAM
D
D
-
L
K
A
EA
KSQ
L
E
E
I
IK
KF
K
L
PT
D
R
VHV
HVE
E
GSP
K
D
R
I
L
ELA
K
K
I
P
A
H
M
II
I
A
S
-
H
RP
D
I
T
T
Y
LLGSNA
AA
V
V
RHA
E
C
S
VLVVR
fig|656419.3.peg.1961
Escherichia coli M718
MNRTILVP
I
D
I
SDS
E
-----
L
T
Q
R
V
I
S
H
-
V
E
AE
A
K
I
DD
A
EVH
F
L
T
V
I
P
SL
P
YY
ASL
G
L
-A
Y
S
A
E
L
PAM
D
D
-
L
K
A
EA
KSQ
L
E
E
I
IK
KF
K
L
PT
D
R
VHV
HVE
E
GSP
K
D
R
I
L
ELA
K
K
I
P
A
H
M
II
I
A
S
-
H
RP
D
I
T
T
Y
LLGSNA
AA
V
V
RHA
E
C
S
VLVVR
fig|679205.4.peg.3442
Escherichia coli MS 124-1
MNRTILVP
I
D
I
SDS
E
-----
L
T
Q
R
V
I
S
H
-
V
E
AE
A
K
I
DD
A
EVH
F
L
T
V
I
P
SL
P
YY
ASL
G
L
-A
Y
S
A
E
L
PAM
D
D
-
L
K
A
EA
KSQ
L
E
E
I
IK
KF
K
L
PT
D
R
VHV
HVE
E
GSP
K
D
R
I
L
ELA
K
K
I
P
A
H
M
II
I
A
S
-
H
RP
D
I
T
T
Y
LLGSNA
AA
V
V
RHA
E
C
S
VLVVR
fig|749546.3.peg.323
Escherichia coli MS 185-1
MNRTILVP
I
D
I
SDS
E
-----
L
T
Q
R
V
I
S
H
-
V
E
AE
A
K
I
DD
A
EVH
F
L
T
V
I
P
SL
P
YY
ASL
G
L
-A
Y
S
A
E
L
PAM
D
D
-
L
K
A
EA
KSQ
L
E
E
I
IK
KF
K
L
PT
D
R
VHV
HVE
E
GSP
K
D
R
I
L
ELA
K
K
I
P
A
H
M
II
I
A
S
-
H
RP
D
I
T
T
Y
LLGSNA
AA
V
V
RHA
E
C
S
VLVVR
fig|749549.3.peg.3928
Escherichia coli MS 198-1
MNRTILVP
I
D
I
SDS
E
-----
L
T
Q
R
V
I
S
H
-
V
E
AE
A
K
I
DD
A
EVH
F
L
T
V
I
P
SL
P
YY
ASL
G
L
-A
Y
S
A
E
L
PAM
D
D
-
L
K
A
EA
KSQ
L
E
E
I
IK
KF
K
L
PT
D
R
VHV
HVE
E
GSP
K
D
R
I
L
ELA
K
K
I
P
A
H
M
II
I
A
S
-
H
RP
D
I
T
T
Y
LLGSNA
AA
V
V
RHA
E
C
S
VLVVR
fig|749550.3.peg.120
Escherichia coli MS 200-1
MNRTILVP
I
D
I
SDS
E
-----
L
T
Q
R
V
I
S
H
-
V
E
AE
A
K
I
DD
A
EVH
F
L
T
V
I
P
SL
P
YY
ASL
G
L
-A
Y
S
A
E
L
PAM
D
D
-
L
K
A
EA
KSQ
L
E
E
I
IK
KF
K
L
PT
D
R
VHV
HVE
E
GSP
K
D
R
I
L
ELA
K
K
I
P
A
H
M
II
I
A
S
-
H
RP
D
I
T
T
Y
LLGSNA
AA
V
V
RHA
E
C
S
VLVVR
fig|749527.3.peg.2349
Escherichia coli MS 21-1
MNRTILVP
I
D
I
SDS
E
-----
L
T
Q
R
V
I
S
H
-
V
E
AE
A
K
I
DD
A
EVH
F
L
T
V
I
P
SL
P
YY
ASL
G
L
-A
Y
S
A
E
L
PAM
D
D
-
L
K
A
EA
KSQ
L
E
E
I
IK
KF
K
L
PT
D
R
VHV
HVE
E
GSP
K
D
R
I
L
ELA
K
K
I
P
A
H
M
II
I
A
S
-
H
RP
D
I
T
T
Y
LLGSNA
AA
V
V
RHA
E
C
S
VLVVR
fig|749528.3.peg.118
Escherichia coli MS 45-1
MNRTILVP
I
D
I
SDS
E
-----
L
T
Q
R
V
I
S
H
-
V
E
AE
A
K
I
DD
A
EVH
F
L
T
V
I
P
SL
P
YY
ASL
G
L
-A
Y
S
A
E
L
PAM
D
D
-
L
K
A
EA
KSQ
L
E
E
I
IK
KF
K
L
PT
D
R
VHV
HVE
E
GSP
K
D
R
I
L
ELA
K
K
I
P
A
H
M
II
I
A
S
-
H
RP
D
I
T
T
Y
LLGSNA
AA
V
V
RHA
E
C
S
VLVVR
fig|749531.3.peg.1647
Escherichia coli MS 69-1
MNRTILVP
I
D
I
SDS
E
-----
L
T
Q
R
V
I
S
H
-
V
E
AE
A
K
I
DD
A
EVH
F
L
T
V
I
P
SL
P
YY
ASL
G
L
-A
Y
S
A
E
L
PAM
D
D
-
L
K
A
EA
KSQ
L
E
E
I
IK
KF
K
L
PT
D
R
VHV
HVE
E
GSP
K
D
R
I
L
ELA
K
K
I
P
A
H
M
II
I
A
S
-
H
RP
D
I
T
T
Y
LLGSNA
AA
V
V
RHA
E
C
S
VLVVR
fig|749533.3.peg.4
Escherichia coli MS 84-1
MNRTILVP
I
D
I
SDS
E
-----
L
T
Q
R
V
I
S
H
-
V
E
AE
A
K
I
DD
A
EVH
F
L
T
V
I
P
SL
P
YY
ASL
G
L
-A
Y
S
A
E
L
PAM
D
D
-
L
K
A
EA
KSQ
L
E
E
I
IK
KF
K
L
PT
D
R
VHV
HVE
E
GSP
K
D
R
I
L
ELA
K
K
I
P
A
H
M
II
I
A
S
-
H
RP
D
I
T
T
Y
LLGSNA
AA
V
V
RHA
E
C
S
VLVVR
fig|753642.3.peg.1762
Escherichia coli NC101
MNRTILVP
I
D
I
SDS
E
-----
L
T
Q
R
V
I
S
H
-
V
E
AE
A
K
I
DD
A
EVH
F
L
T
V
I
P
SL
P
YY
ASL
G
L
-A
Y
S
A
E
L
PAM
D
D
-
L
K
A
EA
KSQ
L
E
E
I
IK
KF
K
L
PT
D
R
VHV
HVE
E
GSP
K
D
R
I
L
ELA
K
K
I
P
A
H
M
II
I
A
S
-
H
RP
D
I
T
T
Y
LLGSNA
AA
V
V
RHA
E
C
S
VLVVR
fig|585396.4.peg.1841
Escherichia coli O111:H- str. 11128
MNRTILVP
I
D
I
SDS
E
-----
L
T
Q
R
V
I
S
H
-
V
E
AE
A
K
I
DD
A
EVH
F
L
T
V
I
P
SL
P
YY
ASL
G
L
-A
Y
S
A
E
L
PAM
D
D
-
L
K
A
EA
KSQ
L
E
E
I
IK
KF
K
L
PT
D
R
VHV
HVE
E
GSP
K
D
R
I
L
ELA
K
K
I
P
A
H
M
II
I
A
S
-
H
RP
D
I
T
T
Y
LLGSNA
AA
V
V
RHA
E
C
S
VLVVR
fig|83334.1.peg.2027
Escherichia coli O157:H7
MNRTILVP
I
D
I
SDS
E
-----
L
T
Q
R
V
I
S
H
-
V
E
AE
A
K
I
DD
A
EVH
F
L
T
V
I
P
SL
P
YY
ASL
G
L
-A
Y
S
A
E
L
PAM
D
D
-
L
K
A
EA
KSQ
L
E
E
I
IK
KF
K
L
PT
D
R
VHV
HVE
E
GSP
K
D
R
I
L
ELA
K
K
I
P
A
H
M
II
I
A
S
-
H
RP
D
I
T
T
Y
LLGSNA
AA
V
V
RHA
E
C
S
VLVVR
fig|155864.8.peg.1905
Escherichia coli O157:H7 EDL933
MNRTILVP
I
D
I
SDS
E
-----
L
T
Q
R
V
I
S
H
-
V
E
AE
A
K
I
DD
A
EVH
F
L
T
V
I
P
SL
P
YY
ASL
G
L
-A
Y
S
A
E
L
PAM
D
D
-
L
K
A
EA
KSQ
L
E
E
I
IK
KF
K
L
PT
D
R
VHV
HVE
E
GSP
K
D
R
I
L
ELA
K
K
I
P
A
H
M
II
I
A
S
-
H
RP
D
I
T
T
Y
LLGSNA
AA
V
V
RHA
E
C
S
VLVVR
fig|444454.5.peg.327
Escherichia coli O157:H7 str. EC4024
MNRTILVP
I
D
I
SDS
E
-----
L
T
Q
R
V
I
S
H
-
V
E
AE
A
K
I
DD
A
EVH
F
L
T
V
I
P
SL
P
YY
ASL
G
L
-A
Y
S
A
E
L
PAM
D
D
-
L
K
A
EA
KSQ
L
E
E
I
IK
KF
K
L
PT
D
R
VHV
HVE
E
GSP
K
D
R
I
L
ELA
K
K
I
P
A
H
M
II
I
A
S
-
H
RP
D
I
T
T
Y
LLGSNA
AA
V
V
RHA
E
C
S
VLVVR
fig|444449.5.peg.228
Escherichia coli O157:H7 str. EC4042
MNRTILVP
I
D
I
SDS
E
-----
L
T
Q
R
V
I
S
H
-
V
E
AE
A
K
I
DD
A
EVH
F
L
T
V
I
P
SL
P
YY
ASL
G
L
-A
Y
S
A
E
L
PAM
D
D
-
L
K
A
EA
KSQ
L
E
E
I
IK
KF
K
L
PT
D
R
VHV
HVE
E
GSP
K
D
R
I
L
ELA
K
K
I
P
A
H
M
II
I
A
S
-
H
RP
D
I
T
T
Y
LLGSNA
AA
V
V
RHA
E
C
S
VLVVR
fig|444448.5.peg.4584
Escherichia coli O157:H7 str. EC4045
MNRTILVP
I
D
I
SDS
E
-----
L
T
Q
R
V
I
S
H
-
V
E
AE
A
K
I
DD
A
EVH
F
L
T
V
I
P
SL
P
YY
ASL
G
L
-A
Y
S
A
E
L
PAM
D
D
-
L
K
A
EA
KSQ
L
E
E
I
IK
KF
K
L
PT
D
R
VHV
HVE
E
GSP
K
D
R
I
L
ELA
K
K
I
P
A
H
M
II
I
A
S
-
H
RP
D
I
T
T
Y
LLGSNA
AA
V
V
RHA
E
C
S
VLVVR
fig|444453.5.peg.4193
Escherichia coli O157:H7 str. EC4076
MNRTILVP
I
D
I
SDS
E
-----
L
T
Q
R
V
I
S
H
-
V
E
AE
A
K
I
DD
A
EVH
F
L
T
V
I
P
SL
P
YY
ASL
G
L
-A
Y
S
A
E
L
PAM
D
D
-
L
K
A
EA
KSQ
L
E
E
I
IK
KF
K
L
PT
D
R
VHV
HVE
E
GSP
K
D
R
I
L
ELA
K
K
I
P
A
H
M
II
I
A
S
-
H
RP
D
I
T
T
Y
LLGSNA
AA
V
V
RHA
E
C
S
VLVVR
fig|444452.5.peg.2039
Escherichia coli O157:H7 str. EC4113
MNRTILVP
I
D
I
SDS
E
-----
L
T
Q
R
V
I
S
H
-
V
E
AE
A
K
I
DD
A
EVH
F
L
T
V
I
P
SL
P
YY
ASL
G
L
-A
Y
S
A
E
L
PAM
D
D
-
L
K
A
EA
KSQ
L
E
E
I
IK
KF
K
L
PT
D
R
VHV
HVE
E
GSP
K
D
R
I
L
ELA
K
K
I
P
A
H
M
II
I
A
S
-
H
RP
D
I
T
T
Y
LLGSNA
AA
V
V
RHA
E
C
S
VLVVR
fig|444450.8.peg.2046
Escherichia coli O157:H7 str. EC4115
MNRTILVP
I
D
I
SDS
E
-----
L
T
Q
R
V
I
S
H
-
V
E
AE
A
K
I
DD
A
EVH
F
L
T
V
I
P
SL
P
YY
ASL
G
L
-A
Y
S
A
E
L
PAM
D
D
-
L
K
A
EA
KSQ
L
E
E
I
IK
KF
K
L
PT
D
R
VHV
HVE
E
GSP
K
D
R
I
L
ELA
K
K
I
P
A
H
M
II
I
A
S
-
H
RP
D
I
T
T
Y
LLGSNA
AA
V
V
RHA
E
C
S
VLVVR
fig|444451.5.peg.2791
Escherichia coli O157:H7 str. EC4196
MNRTILVP
I
D
I
SDS
E
-----
L
T
Q
R
V
I
S
H
-
V
E
AE
A
K
I
DD
A
EVH
F
L
T
V
I
P
SL
P
YY
ASL
G
L
-A
Y
S
A
E
L
PAM
D
D
-
L
K
A
EA
KSQ
L
E
E
I
IK
KF
K
L
PT
D
R
VHV
HVE
E
GSP
K
D
R
I
L
ELA
K
K
I
P
A
H
M
II
I
A
S
-
H
RP
D
I
T
T
Y
LLGSNA
AA
V
V
RHA
E
C
S
VLVVR
fig|444447.5.peg.5493
Escherichia coli O157:H7 str. EC4206
MNRTILVP
I
D
I
SDS
E
-----
L
T
Q
R
V
I
S
H
-
V
E
AE
A
K
I
DD
A
EVH
F
L
T
V
I
P
SL
P
YY
ASL
G
L
-A
Y
S
A
E
L
PAM
D
D
-
L
K
A
EA
KSQ
L
E
E
I
IK
KF
K
L
PT
D
R
VHV
HVE
E
GSP
K
D
R
I
L
ELA
K
K
I
P
A
H
M
II
I
A
S
-
H
RP
D
I
T
T
Y
LLGSNA
AA
V
V
RHA
E
C
S
VLVVR
fig|478004.5.peg.2775
Escherichia coli O157:H7 str. EC4401
MNRTILVP
I
D
I
SDS
E
-----
L
T
Q
R
V
I
S
H
-
V
E
AE
A
K
I
DD
A
EVH
F
L
T
V
I
P
SL
P
YY
ASL
G
L
-A
Y
S
A
E
L
PAM
D
D
-
L
K
A
EA
KSQ
L
E
E
I
IK
KF
K
L
PT
D
R
VHV
HVE
E
GSP
K
D
R
I
L
ELA
K
K
I
P
A
H
M
II
I
A
S
-
H
RP
D
I
T
T
Y
LLGSNA
AA
V
V
RHA
E
C
S
VLVVR
fig|478006.5.peg.3538
Escherichia coli O157:H7 str. EC4501
MNRTILVP
I
D
I
SDS
E
-----
L
T
Q
R
V
I
S
H
-
V
E
AE
A
K
I
DD
A
EVH
F
L
T
V
I
P
SL
P
YY
ASL
G
L
-A
Y
S
A
E
L
PAM
D
D
-
L
K
A
EA
KSQ
L
E
E
I
IK
KF
K
L
PT
D
R
VHV
HVE
E
GSP
K
D
R
I
L
ELA
K
K
I
P
A
H
M
II
I
A
S
-
H
RP
D
I
T
T
Y
LLGSNA
AA
V
V
RHA
E
C
S
VLVVR
fig|478007.5.peg.2393
Escherichia coli O157:H7 str. EC508
MNRTILVP
I
D
I
SDS
E
-----
L
T
Q
R
V
I
S
H
-
V
E
AE
A
K
I
DD
A
EVH
F
L
T
V
I
P
SL
P
YY
ASL
G
L
-A
Y
S
A
E
L
PAM
D
D
-
L
K
A
EA
KSQ
L
E
E
I
IK
KF
K
L
PT
D
R
VHV
HVE
E
GSP
K
D
R
I
L
ELA
K
K
I
P
A
H
M
II
I
A
S
-
H
RP
D
I
T
T
Y
LLGSNA
AA
V
V
RHA
E
C
S
VLVVR
fig|478008.5.peg.3513
Escherichia coli O157:H7 str. EC869
MNRTILVP
I
D
I
SDS
E
-----
L
T
Q
R
V
I
S
H
-
V
E
AE
A
K
I
DD
A
EVH
F
L
T
V
I
P
SL
P
YY
ASL
G
L
-A
Y
S
A
E
L
PAM
D
D
-
L
K
A
EA
KSQ
L
E
E
I
IK
KF
K
L
PT
D
R
VHV
HVE
E
GSP
K
D
R
I
L
ELA
K
K
I
P
A
H
M
II
I
A
S
-
H
RP
D
I
T
T
Y
LLGSNA
AA
V
V
RHA
E
C
S
VLVVR
fig|637388.3.peg.1417
Escherichia coli O157:H7 str. FRIK2000
MNRTILVP
I
D
I
SDS
E
-----
L
T
Q
R
V
I
S
H
-
V
E
AE
A
K
I
DD
A
EVH
F
L
T
V
I
P
SL
P
YY
ASL
G
L
-A
Y
S
A
E
L
PAM
D
D
-
L
K
A
EA
KSQ
L
E
E
I
IK
KF
K
L
PT
D
R
VHV
HVE
E
GSP
K
D
R
I
L
ELA
K
K
I
P
A
H
M
II
I
A
S
-
H
RP
D
I
T
T
Y
LLGSNA
AA
V
V
RHA
E
C
S
VLVVR
fig|570506.3.peg.3296
Escherichia coli O157:H7 str. FRIK966
MNRTILVP
I
D
I
SDS
E
-----
L
T
Q
R
V
I
S
H
-
V
E
AE
A
K
I
DD
A
EVH
F
L
T
V
I
P
SL
P
YY
ASL
G
L
-A
Y
S
A
E
L
PAM
D
D
-
L
K
A
EA
KSQ
L
E
E
I
IK
KF
K
L
PT
D
R
VHV
HVE
E
GSP
K
D
R
I
L
ELA
K
K
I
P
A
H
M
II
I
A
S
-
H
RP
D
I
T
T
Y
LLGSNA
AA
V
V
RHA
E
C
S
VLVVR
fig|386585.9.peg.2098
Escherichia coli O157:H7 str. Sakai
MNRTILVP
I
D
I
SDS
E
-----
L
T
Q
R
V
I
S
H
-
V
E
AE
A
K
I
DD
A
EVH
F
L
T
V
I
P
SL
P
YY
ASL
G
L
-A
Y
S
A
E
L
PAM
D
D
-
L
K
A
EA
KSQ
L
E
E
I
IK
KF
K
L
PT
D
R
VHV
HVE
E
GSP
K
D
R
I
L
ELA
K
K
I
P
A
H
M
II
I
A
S
-
H
RP
D
I
T
T
Y
LLGSNA
AA
V
V
RHA
E
C
S
VLVVR
fig|544404.4.peg.1907
Escherichia coli O157:H7 str. TW14359
MNRTILVP
I
D
I
SDS
E
-----
L
T
Q
R
V
I
S
H
-
V
E
AE
A
K
I
DD
A
EVH
F
L
T
V
I
P
SL
P
YY
ASL
G
L
-A
Y
S
A
E
L
PAM
D
D
-
L
K
A
EA
KSQ
L
E
E
I
IK
KF
K
L
PT
D
R
VHV
HVE
E
GSP
K
D
R
I
L
ELA
K
K
I
P
A
H
M
II
I
A
S
-
H
RP
D
I
T
T
Y
LLGSNA
AA
V
V
RHA
E
C
S
VLVVR
fig|502346.5.peg.5374
Escherichia coli O157:H7 str. TW14588
MNRTILVP
I
D
I
SDS
E
-----
L
T
Q
R
V
I
S
H
-
V
E
AE
A
K
I
DD
A
EVH
F
L
T
V
I
P
SL
P
YY
ASL
G
L
-A
Y
S
A
E
L
PAM
D
D
-
L
K
A
EA
KSQ
L
E
E
I
IK
KF
K
L
PT
D
R
VHV
HVE
E
GSP
K
D
R
I
L
ELA
K
K
I
P
A
H
M
II
I
A
S
-
H
RP
D
I
T
T
Y
LLGSNA
AA
V
V
RHA
E
C
S
VLVVR
fig|573235.3.peg.2011
Escherichia coli O26:H11 str. 11368
MNRTILVP
I
D
I
SDS
E
-----
L
T
Q
R
V
I
S
H
-
V
E
AE
A
K
I
DD
A
EVH
F
L
T
V
I
P
SL
P
YY
ASL
G
L
-A
Y
S
A
E
L
PAM
D
D
-
L
K
A
EA
KSQ
L
E
E
I
IK
KF
K
L
PT
D
R
VHV
HVE
E
GSP
K
D
R
I
L
ELA
K
K
I
P
A
H
M
II
I
A
S
-
H
RP
D
I
T
T
Y
LLGSNA
AA
V
V
RHA
E
C
S
VLVVR
fig|701177.3.peg.1743
Escherichia coli O55:H7 str. CB9615
MNRTILVP
I
D
I
SDS
E
-----
L
T
Q
R
V
I
S
H
-
V
E
AE
A
K
I
DD
A
EVH
F
L
T
V
I
P
SL
P
YY
ASL
G
L
-A
Y
S
A
E
L
PAM
D
D
-
L
K
A
EA
KSQ
L
E
E
I
IK
KF
K
L
PT
D
R
VHV
HVE
E
GSP
K
D
R
I
L
ELA
K
K
I
P
A
H
M
II
I
A
S
-
H
RP
D
I
T
T
Y
LLGSNA
AA
V
V
RHA
E
C
S
VLVVR
fig|685038.3.peg.1389
Escherichia coli O83:H1 str. NRG 857C
MNRTILVP
I
D
I
SDS
E
-----
L
T
Q
R
V
I
S
H
-
V
E
AE
A
K
I
DD
A
EVH
F
L
T
V
I
P
SL
P
YY
ASL
G
L
-A
Y
S
A
E
L
PAM
D
D
-
L
K
A
EA
KSQ
L
E
E
I
IK
KF
K
L
PT
D
R
VHV
HVE
E
GSP
K
D
R
I
L
ELA
K
K
I
P
A
H
M
II
I
A
S
-
H
RP
D
I
T
T
Y
LLGSNA
AA
V
V
RHA
E
C
S
VLVVR
fig|585035.6.peg.1482
Escherichia coli S88
MNRTILVP
I
D
I
SDS
E
-----
L
T
Q
R
V
I
S
H
-
V
E
AE
A
K
I
DD
A
EVH
F
L
T
V
I
P
SL
P
YY
ASL
G
L
-A
Y
S
A
E
L
PAM
D
D
-
L
K
A
EA
KSQ
L
E
E
I
IK
KF
K
L
PT
D
R
VHV
HVE
E
GSP
K
D
R
I
L
ELA
K
K
I
P
A
H
M
II
I
A
S
-
H
RP
D
I
T
T
Y
LLGSNA
AA
V
V
RHA
E
C
S
VLVVR
fig|431946.3.peg.1377
Escherichia coli SE15
MNRTILVP
I
D
I
SDS
E
-----
L
T
Q
R
V
I
S
H
-
V
E
AE
A
K
I
DD
A
EVH
F
L
T
V
I
P
SL
P
YY
ASL
G
L
-A
Y
S
A
E
L
PAM
D
D
-
L
K
A
EA
KSQ
L
E
E
I
IK
KF
K
L
PT
D
R
VHV
HVE
E
GSP
K
D
R
I
L
ELA
K
K
I
P
A
H
M
II
I
A
S
-
H
RP
D
I
T
T
Y
LLGSNA
AA
V
V
RHA
E
C
S
VLVVR
fig|439855.10.peg.1931
Escherichia coli SMS-3-5
MNRTILVP
I
D
I
SDS
E
-----
L
T
Q
R
V
I
S
H
-
V
E
AE
A
K
I
DD
A
EVH
F
L
T
V
I
P
SL
P
YY
ASL
G
L
-A
Y
S
A
E
L
PAM
D
D
-
L
K
A
EA
KSQ
L
E
E
I
IK
KF
K
L
PT
D
R
VHV
HVE
E
GSP
K
D
R
I
L
ELA
K
K
I
P
A
H
M
II
I
A
S
-
H
RP
D
I
T
T
Y
LLGSNA
AA
V
V
RHA
E
C
S
VLVVR
fig|656437.3.peg.1596
Escherichia coli TA143
MNRTILVP
I
D
I
SDS
E
-----
L
T
Q
R
V
I
S
H
-
V
E
AE
A
K
I
DD
A
EVH
F
L
T
V
I
P
SL
P
YY
ASL
G
L
-A
Y
S
A
E
L
PAM
D
D
-
L
K
A
EA
KSQ
L
E
E
I
IK
KF
K
L
PT
D
R
VHV
HVE
E
GSP
K
D
R
I
L
ELA
K
K
I
P
A
H
M
II
I
A
S
-
H
RP
D
I
T
T
Y
LLGSNA
AA
V
V
RHA
E
C
S
VLVVR
fig|656440.3.peg.1261
Escherichia coli TA206
MNRTILVP
I
D
I
SDS
E
-----
L
T
Q
R
V
I
S
H
-
V
E
AE
A
K
I
DD
A
EVH
F
L
T
V
I
P
SL
P
YY
ASL
G
L
-A
Y
S
A
E
L
PAM
D
D
-
L
K
A
EA
KSQ
L
E
E
I
IK
KF
K
L
PT
D
R
VHV
HVE
E
GSP
K
D
R
I
L
ELA
K
K
I
P
A
H
M
II
I
A
S
-
H
RP
D
I
T
T
Y
LLGSNA
AA
V
V
RHA
E
C
S
VLVVR
fig|656444.3.peg.2170
Escherichia coli TA280
MNRTILVP
I
D
I
SDS
E
-----
L
T
Q
R
V
I
S
H
-
V
E
AE
A
K
I
DD
A
EVH
F
L
T
V
I
P
SL
P
YY
ASL
G
L
-A
Y
S
A
E
L
PAM
D
D
-
L
K
A
EA
KSQ
L
E
E
I
IK
KF
K
L
PT
D
R
VHV
HVE
E
GSP
K
D
R
I
L
ELA
K
K
I
P
A
H
M
II
I
A
S
-
H
RP
D
I
T
T
Y
LLGSNA
AA
V
V
RHA
E
C
S
VLVVR
fig|869729.3.peg.2132
Escherichia coli UM146
MNRTILVP
I
D
I
SDS
E
-----
L
T
Q
R
V
I
S
H
-
V
E
AE
A
K
I
DD
A
EVH
F
L
T
V
I
P
SL
P
YY
ASL
G
L
-A
Y
S
A
E
L
PAM
D
D
-
L
K
A
EA
KSQ
L
E
E
I
IK
KF
K
L
PT
D
R
VHV
HVE
E
GSP
K
D
R
I
L
ELA
K
K
I
P
A
H
M
II
I
A
S
-
H
RP
D
I
T
T
Y
LLGSNA
AA
V
V
RHA
E
C
S
VLVVR
fig|585056.7.peg.1835
Escherichia coli UMN026
MNRTILVP
I
D
I
SDS
E
-----
L
T
Q
R
V
I
S
H
-
V
E
AE
A
K
I
DD
A
EVH
F
L
T
V
I
P
SL
P
YY
ASL
G
L
-A
Y
S
A
E
L
PAM
D
D
-
L
K
A
EA
KSQ
L
E
E
I
IK
KF
K
L
PT
D
R
VHV
HVE
E
GSP
K
D
R
I
L
ELA
K
K
I
P
A
H
M
II
I
A
S
-
H
RP
D
I
T
T
Y
LLGSNA
AA
V
V
RHA
E
C
S
VLVVR
fig|364106.7.peg.1660
Escherichia coli UTI89
MNRTILVP
I
D
I
SDS
E
-----
L
T
Q
R
V
I
S
H
-
V
E
AE
A
K
I
DD
A
EVH
F
L
T
V
I
P
SL
P
YY
ASL
G
L
-A
Y
S
A
E
L
PAM
D
D
-
L
K
A
EA
KSQ
L
E
E
I
IK
KF
K
L
PT
D
R
VHV
HVE
E
GSP
K
D
R
I
L
ELA
K
K
I
P
A
H
M
II
I
A
S
-
H
RP
D
I
T
T
Y
LLGSNA
AA
V
V
RHA
E
C
S
VLVVR
fig|364106.8.peg.1661
Escherichia coli UTI89
MNRTILVP
I
D
I
SDS
E
-----
L
T
Q
R
V
I
S
H
-
V
E
AE
A
K
I
DD
A
EVH
F
L
T
V
I
P
SL
P
YY
ASL
G
L
-A
Y
S
A
E
L
PAM
D
D
-
L
K
A
EA
KSQ
L
E
E
I
IK
KF
K
L
PT
D
R
VHV
HVE
E
GSP
K
D
R
I
L
ELA
K
K
I
P
A
H
M
II
I
A
S
-
H
RP
D
I
T
T
Y
LLGSNA
AA
V
V
RHA
E
C
S
VLVVR
fig|562.376.peg.3106
Escherichia coli WV_060327
MNRTILVP
I
D
I
SDS
E
-----
L
T
Q
R
V
I
S
H
-
V
E
AE
A
K
I
DD
A
EVH
F
L
T
V
I
P
SL
P
YY
ASL
G
L
-A
Y
S
A
E
L
PAM
D
D
-
L
K
A
EA
KSQ
L
E
E
I
IK
KF
K
L
PT
D
R
VHV
HVE
E
GSP
K
D
R
I
L
ELA
K
K
I
P
A
H
M
II
I
A
S
-
H
RP
D
I
T
T
Y
LLGSNA
AA
V
V
RHA
E
C
S
VLVVR
fig|358709.5.peg.885
Escherichia coli 101-1
MNRTILVP
I
D
I
SDS
E
-----
L
T
Q
R
V
I
S
H
-
V
E
EE
A
K
I
DD
A
EVH
F
L
T
V
I
P
SL
P
YY
ASL
G
L
-A
Y
S
A
E
L
PAM
D
D
-
L
K
A
EA
KSQ
L
E
E
I
IK
KF
K
L
PT
D
R
VHV
HVE
E
GSP
K
D
R
I
L
ELA
K
K
I
P
A
H
M
II
I
A
S
-
H
RP
D
I
T
T
Y
LLGSNA
AA
V
V
RHA
E
C
S
VLVVR
fig|670888.3.peg.2042
Escherichia coli 1827-70
MNRTILVP
I
D
I
SDS
E
-----
L
T
Q
R
V
I
S
H
-
V
E
EE
A
K
I
DD
A
EVH
F
L
T
V
I
P
SL
P
YY
ASL
G
L
-A
Y
S
A
E
L
PAM
D
D
-
L
K
A
EA
KSQ
L
E
E
I
IK
KF
K
L
PT
D
R
VHV
HVE
E
GSP
K
D
R
I
L
ELA
K
K
I
P
A
H
M
II
I
A
S
-
H
RP
D
I
T
T
Y
LLGSNA
AA
V
V
RHA
E
C
S
VLVVR
fig|344610.7.peg.5034
Escherichia coli 53638
MNRTILVP
I
D
I
SDS
E
-----
L
T
Q
R
V
I
S
H
-
V
E
EE
A
K
I
DD
A
EVH
F
L
T
V
I
P
SL
P
YY
ASL
G
L
-A
Y
S
A
E
L
PAM
D
D
-
L
K
A
EA
KSQ
L
E
E
I
IK
KF
K
L
PT
D
R
VHV
HVE
E
GSP
K
D
R
I
L
ELA
K
K
I
P
A
H
M
II
I
A
S
-
H
RP
D
I
T
T
Y
LLGSNA
AA
V
V
RHA
E
C
S
VLVVR
fig|481805.6.peg.2435
Escherichia coli ATCC 8739
MNRTILVP
I
D
I
SDS
E
-----
L
T
Q
R
V
I
S
H
-
V
E
EE
A
K
I
DD
A
EVH
F
L
T
V
I
P
SL
P
YY
ASL
G
L
-A
Y
S
A
E
L
PAM
D
D
-
L
K
A
EA
KSQ
L
E
E
I
IK
KF
K
L
PT
D
R
VHV
HVE
E
GSP
K
D
R
I
L
ELA
K
K
I
P
A
H
M
II
I
A
S
-
H
RP
D
I
T
T
Y
LLGSNA
AA
V
V
RHA
E
C
S
VLVVR
fig|413997.3.peg.1420
Escherichia coli B str. REL606
MNRTILVP
I
D
I
SDS
E
-----
L
T
Q
R
V
I
S
H
-
V
E
EE
A
K
I
DD
A
EVH
F
L
T
V
I
P
SL
P
YY
ASL
G
L
-A
Y
S
A
E
L
PAM
D
D
-
L
K
A
EA
KSQ
L
E
E
I
IK
KF
K
L
PT
D
R
VHV
HVE
E
GSP
K
D
R
I
L
ELA
K
K
I
P
A
H
M
II
I
A
S
-
H
RP
D
I
T
T
Y
LLGSNA
AA
V
V
RHA
E
C
S
VLVVR
fig|511693.5.peg.1457
Escherichia coli BL21
MNRTILVP
I
D
I
SDS
E
-----
L
T
Q
R
V
I
S
H
-
V
E
EE
A
K
I
DD
A
EVH
F
L
T
V
I
P
SL
P
YY
ASL
G
L
-A
Y
S
A
E
L
PAM
D
D
-
L
K
A
EA
KSQ
L
E
E
I
IK
KF
K
L
PT
D
R
VHV
HVE
E
GSP
K
D
R
I
L
ELA
K
K
I
P
A
H
M
II
I
A
S
-
H
RP
D
I
T
T
Y
LLGSNA
AA
V
V
RHA
E
C
S
VLVVR
fig|469008.4.peg.2315
Escherichia coli BL21(DE3)
MNRTILVP
I
D
I
SDS
E
-----
L
T
Q
R
V
I
S
H
-
V
E
EE
A
K
I
DD
A
EVH
F
L
T
V
I
P
SL
P
YY
ASL
G
L
-A
Y
S
A
E
L
PAM
D
D
-
L
K
A
EA
KSQ
L
E
E
I
IK
KF
K
L
PT
D
R
VHV
HVE
E
GSP
K
D
R
I
L
ELA
K
K
I
P
A
H
M
II
I
A
S
-
H
RP
D
I
T
T
Y
LLGSNA
AA
V
V
RHA
E
C
S
VLVVR
fig|595496.3.peg.1327
Escherichia coli BW2952
MNRTILVP
I
D
I
SDS
E
-----
L
T
Q
R
V
I
S
H
-
V
E
EE
A
K
I
DD
A
EVH
F
L
T
V
I
P
SL
P
YY
ASL
G
L
-A
Y
S
A
E
L
PAM
D
D
-
L
K
A
EA
KSQ
L
E
E
I
IK
KF
K
L
PT
D
R
VHV
HVE
E
GSP
K
D
R
I
L
ELA
K
K
I
P
A
H
M
II
I
A
S
-
H
RP
D
I
T
T
Y
LLGSNA
AA
V
V
RHA
E
C
S
VLVVR
fig|536056.3.peg.2383
Escherichia coli DH1
MNRTILVP
I
D
I
SDS
E
-----
L
T
Q
R
V
I
S
H
-
V
E
EE
A
K
I
DD
A
EVH
F
L
T
V
I
P
SL
P
YY
ASL
G
L
-A
Y
S
A
E
L
PAM
D
D
-
L
K
A
EA
KSQ
L
E
E
I
IK
KF
K
L
PT
D
R
VHV
HVE
E
GSP
K
D
R
I
L
ELA
K
K
I
P
A
H
M
II
I
A
S
-
H
RP
D
I
T
T
Y
LLGSNA
AA
V
V
RHA
E
C
S
VLVVR
fig|316401.4.peg.1668
Escherichia coli ETEC H10407
MNRTILVP
I
D
I
SDS
E
-----
L
T
Q
R
V
I
S
H
-
V
E
EE
A
K
I
DD
A
EVH
F
L
T
V
I
P
SL
P
YY
ASL
G
L
-A
Y
S
A
E
L
PAM
D
D
-
L
K
A
EA
KSQ
L
E
E
I
IK
KF
K
L
PT
D
R
VHV
HVE
E
GSP
K
D
R
I
L
ELA
K
K
I
P
A
H
M
II
I
A
S
-
H
RP
D
I
T
T
Y
LLGSNA
AA
V
V
RHA
E
C
S
VLVVR
fig|656414.3.peg.1654
Escherichia coli H736
MNRTILVP
I
D
I
SDS
E
-----
L
T
Q
R
V
I
S
H
-
V
E
EE
A
K
I
DD
A
EVH
F
L
T
V
I
P
SL
P
YY
ASL
G
L
-A
Y
S
A
E
L
PAM
D
D
-
L
K
A
EA
KSQ
L
E
E
I
IK
KF
K
L
PT
D
R
VHV
HVE
E
GSP
K
D
R
I
L
ELA
K
K
I
P
A
H
M
II
I
A
S
-
H
RP
D
I
T
T
Y
LLGSNA
AA
V
V
RHA
E
C
S
VLVVR
fig|331112.6.peg.1427
Escherichia coli HS
MNRTILVP
I
D
I
SDS
E
-----
L
T
Q
R
V
I
S
H
-
V
E
EE
A
K
I
DD
A
EVH
F
L
T
V
I
P
SL
P
YY
ASL
G
L
-A
Y
S
A
E
L
PAM
D
D
-
L
K
A
EA
KSQ
L
E
E
I
IK
KF
K
L
PT
D
R
VHV
HVE
E
GSP
K
D
R
I
L
ELA
K
K
I
P
A
H
M
II
I
A
S
-
H
RP
D
I
T
T
Y
LLGSNA
AA
V
V
RHA
E
C
S
VLVVR
fig|83333.1.peg.1366
Escherichia coli K12
MNRTILVP
I
D
I
SDS
E
-----
L
T
Q
R
V
I
S
H
-
V
E
EE
A
K
I
DD
A
EVH
F
L
T
V
I
P
SL
P
YY
ASL
G
L
-A
Y
S
A
E
L
PAM
D
D
-
L
K
A
EA
KSQ
L
E
E
I
IK
KF
K
L
PT
D
R
VHV
HVE
E
GSP
K
D
R
I
L
ELA
K
K
I
P
A
H
M
II
I
A
S
-
H
RP
D
I
T
T
Y
LLGSNA
AA
V
V
RHA
E
C
S
VLVVR
fig|749540.3.peg.3528
Escherichia coli MS 146-1
MNRTILVP
I
D
I
SDS
E
-----
L
T
Q
R
V
I
S
H
-
V
E
EE
A
K
I
DD
A
EVH
F
L
T
V
I
P
SL
P
YY
ASL
G
L
-A
Y
S
A
E
L
PAM
D
D
-
L
K
A
EA
KSQ
L
E
E
I
IK
KF
K
L
PT
D
R
VHV
HVE
E
GSP
K
D
R
I
L
ELA
K
K
I
P
A
H
M
II
I
A
S
-
H
RP
D
I
T
T
Y
LLGSNA
AA
V
V
RHA
E
C
S
VLVVR
fig|749544.3.peg.520
Escherichia coli MS 175-1
MNRTILVP
I
D
I
SDS
E
-----
L
T
Q
R
V
I
S
H
-
V
E
EE
A
K
I
DD
A
EVH
F
L
T
V
I
P
SL
P
YY
ASL
G
L
-A
Y
S
A
E
L
PAM
D
D
-
L
K
A
EA
KSQ
L
E
E
I
IK
KF
K
L
PT
D
R
VHV
HVE
E
GSP
K
D
R
I
L
ELA
K
K
I
P
A
H
M
II
I
A
S
-
H
RP
D
I
T
T
Y
LLGSNA
AA
V
V
RHA
E
C
S
VLVVR
fig|749547.3.peg.229
Escherichia coli MS 187-1
MNRTILVP
I
D
I
SDS
E
-----
L
T
Q
R
V
I
S
H
-
V
E
EE
A
K
I
DD
A
EVH
F
L
T
V
I
P
SL
P
YY
ASL
G
L
-A
Y
S
A
E
L
PAM
D
D
-
L
K
A
EA
KSQ
L
E
E
I
IK
KF
K
L
PT
D
R
VHV
HVE
E
GSP
K
D
R
I
L
ELA
K
K
I
P
A
H
M
II
I
A
S
-
H
RP
D
I
T
T
Y
LLGSNA
AA
V
V
RHA
E
C
S
VLVVR
fig|749548.3.peg.497
Escherichia coli MS 196-1
MNRTILVP
I
D
I
SDS
E
-----
L
T
Q
R
V
I
S
H
-
V
E
EE
A
K
I
DD
A
EVH
F
L
T
V
I
P
SL
P
YY
ASL
G
L
-A
Y
S
A
E
L
PAM
D
D
-
L
K
A
EA
KSQ
L
E
E
I
IK
KF
K
L
PT
D
R
VHV
HVE
E
GSP
K
D
R
I
L
ELA
K
K
I
P
A
H
M
II
I
A
S
-
H
RP
D
I
T
T
Y
LLGSNA
AA
V
V
RHA
E
C
S
VLVVR
fig|637912.3.peg.4550
Escherichia coli OP50
MNRTILVP
I
D
I
SDS
E
-----
L
T
Q
R
V
I
S
H
-
V
E
EE
A
K
I
DD
A
EVH
F
L
T
V
I
P
SL
P
YY
ASL
G
L
-A
Y
S
A
E
L
PAM
D
D
-
L
K
A
EA
KSQ
L
E
E
I
IK
KF
K
L
PT
D
R
VHV
HVE
E
GSP
K
D
R
I
L
ELA
K
K
I
P
A
H
M
II
I
A
S
-
H
RP
D
I
T
T
Y
LLGSNA
AA
V
V
RHA
E
C
S
VLVVR
fig|316407.3.peg.1338
Escherichia coli W3110
MNRTILVP
I
D
I
SDS
E
-----
L
T
Q
R
V
I
S
H
-
V
E
EE
A
K
I
DD
A
EVH
F
L
T
V
I
P
SL
P
YY
ASL
G
L
-A
Y
S
A
E
L
PAM
D
D
-
L
K
A
EA
KSQ
L
E
E
I
IK
KF
K
L
PT
D
R
VHV
HVE
E
GSP
K
D
R
I
L
ELA
K
K
I
P
A
H
M
II
I
A
S
-
H
RP
D
I
T
T
Y
LLGSNA
AA
V
V
RHA
E
C
S
VLVVR
fig|316385.7.peg.1526
Escherichia coli str. K-12 substr. DH10B
MNRTILVP
I
D
I
SDS
E
-----
L
T
Q
R
V
I
S
H
-
V
E
EE
A
K
I
DD
A
EVH
F
L
T
V
I
P
SL
P
YY
ASL
G
L
-A
Y
S
A
E
L
PAM
D
D
-
L
K
A
EA
KSQ
L
E
E
I
IK
KF
K
L
PT
D
R
VHV
HVE
E
GSP
K
D
R
I
L
ELA
K
K
I
P
A
H
M
II
I
A
S
-
H
RP
D
I
T
T
Y
LLGSNA
AA
V
V
RHA
E
C
S
VLVVR
fig|511145.12.peg.1438
Escherichia coli str. K-12 substr. MG1655
MNRTILVP
I
D
I
SDS
E
-----
L
T
Q
R
V
I
S
H
-
V
E
EE
A
K
I
DD
A
EVH
F
L
T
V
I
P
SL
P
YY
ASL
G
L
-A
Y
S
A
E
L
PAM
D
D
-
L
K
A
EA
KSQ
L
E
E
I
IK
KF
K
L
PT
D
R
VHV
HVE
E
GSP
K
D
R
I
L
ELA
K
K
I
P
A
H
M
II
I
A
S
-
H
RP
D
I
T
T
Y
LLGSNA
AA
V
V
RHA
E
C
S
VLVVR
fig|511145.6.peg.1425
Escherichia coli str. K-12 substr. MG1655
MNRTILVP
I
D
I
SDS
E
-----
L
T
Q
R
V
I
S
H
-
V
E
EE
A
K
I
DD
A
EVH
F
L
T
V
I
P
SL
P
YY
ASL
G
L
-A
Y
S
A
E
L
PAM
D
D
-
L
K
A
EA
KSQ
L
E
E
I
IK
KF
K
L
PT
D
R
VHV
HVE
E
GSP
K
D
R
I
L
ELA
K
K
I
P
A
H
M
II
I
A
S
-
H
RP
D
I
T
T
Y
LLGSNA
AA
V
V
RHA
E
C
S
VLVVR
fig|749538.3.peg.1856
Escherichia coli MS 116-1
MNRTILVP
I
D
I
SDS
E
-----
L
T
Q
R
V
I
S
H
-
V
E
EE
A
K
I
DD
A
EVH
F
L
T
V
I
P
SL
S
YY
ASL
G
L
-A
Y
S
A
E
L
PAM
D
D
-
L
K
A
EA
KSQ
L
E
E
I
IK
KF
K
L
PT
D
R
VHV
HVE
E
GSP
K
D
R
I
L
ELA
K
K
I
P
A
H
M
II
I
A
S
-
H
RP
D
I
T
T
Y
LLGSNA
AA
V
V
RHA
E
C
S
VLVVR
fig|199310.1.peg.671
Escherichia coli CFT073 (12-153/153)
M
YK
TI
IM
PVD
V
FEM
E
-----
LSDK
A
I
R
H
-
A
E
FL
AQ
-
DD
G
VI
HLL
H
V
L
P
G-
-
-S
ASL
S
L
HR
F
A
A
D
V
RRF
E
E
H
LQ
H
EA
EER
LQ
T
M
VS
H
F
T
I
DP
SR
IKQ
HV
R
F
GS
V
RD
E
V
N
ELA
K
E
L
D
A
D
VVVIGS
-
R
N
P
S
IST
H
LLGSNA
SS
VIRHA
N
L
P
VLVVR
fig|216593.1.peg.3009
Escherichia coli E2348/69 (12-153/153)
M
YK
TI
IM
PVD
V
FEM
E
-----
LSDK
A
I
R
H
-
A
E
FL
AQ
-
DD
G
VI
HLL
H
V
L
P
G-
-
-S
ASL
S
L
HR
F
A
A
D
V
RRF
E
E
H
LQ
H
EA
EER
LQ
T
M
VS
H
F
T
I
DP
SR
IKQ
HV
R
F
GS
V
RD
E
V
N
ELA
K
E
L
D
A
D
VVVIGS
-
R
N
P
S
IST
H
LLGSNA
SS
VIRHA
N
L
P
VLVVR
fig|340197.3.peg.2447
Escherichia coli F11 (12-153/153)
M
YK
TI
IM
PVD
V
FEM
E
-----
LSDK
A
I
R
H
-
A
E
FL
AQ
-
DD
G
VI
HLL
H
V
L
P
G-
-
-S
ASL
S
L
HR
F
A
A
D
V
RRF
E
E
H
LQ
H
EA
EER
LQ
T
M
VS
H
F
T
I
DP
SR
IKQ
HV
R
F
GS
V
RD
E
V
N
ELA
K
E
L
D
A
D
VVVIGS
-
R
N
P
S
IST
H
LLGSNA
SS
VIRHA
N
L
P
VLVVR
fig|216592.1.peg.366
Escherichia coli 042 (12-153/153)
M
YK
TI
IM
PVD
V
FEM
E
-----
LSDK
A
V
R
H
-
A
E
FL
AQ
-
DD
G
VI
HLL
H
V
L
P
G-
-
-S
ASL
S
L
HR
F
A
A
D
V
RRF
E
E
H
LQ
H
EA
EER
LQ
T
M
VS
H
F
T
I
DP
SR
IKQ
HV
R
F
GS
V
RD
E
V
N
ELA
K
E
L
D
A
D
VVVIGS
-
R
N
P
S
IST
H
LLGSNA
SS
VIRHA
N
L
P
VLVVR
fig|405955.9.peg.484
Escherichia coli APEC O1 (12-153/153)
M
YK
TI
IM
PVD
V
FEM
E
-----
LSDK
A
V
R
H
-
A
E
FL
AQ
-
DD
G
VI
HLL
H
V
L
P
G-
-
-S
ASL
S
L
HR
F
A
A
D
V
RRF
E
E
H
LQ
H
EA
EER
LQ
T
M
VS
H
F
T
I
DP
SR
IKQ
HV
R
F
GS
V
RD
E
V
N
ELA
K
E
L
D
A
D
VVVIGS
-
R
N
P
S
IST
H
LLGSNA
SS
VIRHA
N
L
P
VLVVR
fig|362663.8.peg.644
Escherichia coli 536
M
YK
TI
IM
PVD
V
FEM
E
-----
LSDK
A
I
R
H
-
A
E
FL
AQ
-
DD
G
VI
HLL
H
V
L
P
G-
-
-S
ASL
S
L
HR
F
A
A
D
V
RRF
E
E
H
LQ
H
EA
EER
LQ
T
M
VS
H
F
T
I
DP
SR
IKQ
HV
R
F
GS
V
RD
E
V
N
ELA
K
E
L
D
A
D
VVVIGS
-
R
N
P
S
IST
H
LLGSNA
SS
VIRHA
N
L
P
VLVVR
fig|362663.9.peg.644
Escherichia coli 536
M
YK
TI
IM
PVD
V
FEM
E
-----
LSDK
A
I
R
H
-
A
E
FL
AQ
-
DD
G
VI
HLL
H
V
L
P
G-
-
-S
ASL
S
L
HR
F
A
A
D
V
RRF
E
E
H
LQ
H
EA
EER
LQ
T
M
VS
H
F
T
I
DP
SR
IKQ
HV
R
F
GS
V
RD
E
V
N
ELA
K
E
L
D
A
D
VVVIGS
-
R
N
P
S
IST
H
LLGSNA
SS
VIRHA
N
L
P
VLVVR
fig|525281.3.peg.2328
Escherichia coli 83972
M
YK
TI
IM
PVD
V
FEM
E
-----
LSDK
A
I
R
H
-
A
E
FL
AQ
-
DD
G
VI
HLL
H
V
L
P
G-
-
-S
ASL
S
L
HR
F
A
A
D
V
RRF
E
E
H
LQ
H
EA
EER
LQ
T
M
VS
H
F
T
I
DP
SR
IKQ
HV
R
F
GS
V
RD
E
V
N
ELA
K
E
L
D
A
D
VVVIGS
-
R
N
P
S
IST
H
LLGSNA
SS
VIRHA
N
L
P
VLVVR
fig|655817.3.peg.704
Escherichia coli ABU 83972
M
YK
TI
IM
PVD
V
FEM
E
-----
LSDK
A
I
R
H
-
A
E
FL
AQ
-
DD
G
VI
HLL
H
V
L
P
G-
-
-S
ASL
S
L
HR
F
A
A
D
V
RRF
E
E
H
LQ
H
EA
EER
LQ
T
M
VS
H
F
T
I
DP
SR
IKQ
HV
R
F
GS
V
RD
E
V
N
ELA
K
E
L
D
A
D
VVVIGS
-
R
N
P
S
IST
H
LLGSNA
SS
VIRHA
N
L
P
VLVVR
fig|199310.4.peg.662
Escherichia coli CFT073
M
YK
TI
IM
PVD
V
FEM
E
-----
LSDK
A
I
R
H
-
A
E
FL
AQ
-
DD
G
VI
HLL
H
V
L
P
G-
-
-S
ASL
S
L
HR
F
A
A
D
V
RRF
E
E
H
LQ
H
EA
EER
LQ
T
M
VS
H
F
T
I
DP
SR
IKQ
HV
R
F
GS
V
RD
E
V
N
ELA
K
E
L
D
A
D
VVVIGS
-
R
N
P
S
IST
H
LLGSNA
SS
VIRHA
N
L
P
VLVVR
fig|585397.7.peg.608
Escherichia coli ED1a
M
YK
TI
IM
PVD
V
FEM
E
-----
LSDK
A
I
R
H
-
A
E
FL
AQ
-
DD
G
VI
HLL
H
V
L
P
G-
-
-S
ASL
S
L
HR
F
A
A
D
V
RRF
E
E
H
LQ
H
EA
EER
LQ
T
M
VS
H
F
T
I
DP
SR
IKQ
HV
R
F
GS
V
RD
E
V
N
ELA
K
E
L
D
A
D
VVVIGS
-
R
N
P
S
IST
H
LLGSNA
SS
VIRHA
N
L
P
VLVVR
fig|585397.9.peg.610
Escherichia coli ED1a
M
YK
TI
IM
PVD
V
FEM
E
-----
LSDK
A
I
R
H
-
A
E
FL
AQ
-
DD
G
VI
HLL
H
V
L
P
G-
-
-S
ASL
S
L
HR
F
A
A
D
V
RRF
E
E
H
LQ
H
EA
EER
LQ
T
M
VS
H
F
T
I
DP
SR
IKQ
HV
R
F
GS
V
RD
E
V
N
ELA
K
E
L
D
A
D
VVVIGS
-
R
N
P
S
IST
H
LLGSNA
SS
VIRHA
N
L
P
VLVVR
fig|340197.5.peg.2566
Escherichia coli F11
M
YK
TI
IM
PVD
V
FEM
E
-----
LSDK
A
I
R
H
-
A
E
FL
AQ
-
DD
G
VI
HLL
H
V
L
P
G-
-
-S
ASL
S
L
HR
F
A
A
D
V
RRF
E
E
H
LQ
H
EA
EER
LQ
T
M
VS
H
F
T
I
DP
SR
IKQ
HV
R
F
GS
V
RD
E
V
N
ELA
K
E
L
D
A
D
VVVIGS
-
R
N
P
S
IST
H
LLGSNA
SS
VIRHA
N
L
P
VLVVR
fig|656393.3.peg.1287
Escherichia coli H299
M
YK
TI
IM
PVD
V
FEM
E
-----
LSDK
A
I
R
H
-
A
E
FL
AQ
-
DD
G
VI
HLL
H
V
L
P
G-
-
-S
ASL
S
L
HR
F
A
A
D
V
RRF
E
E
H
LQ
H
EA
EER
LQ
T
M
VS
H
F
T
I
DP
SR
IKQ
HV
R
F
GS
V
RD
E
V
N
ELA
K
E
L
D
A
D
VVVIGS
-
R
N
P
S
IST
H
LLGSNA
SS
VIRHA
N
L
P
VLVVR
fig|656417.3.peg.733
Escherichia coli M605
M
YK
TI
IM
PVD
V
FEM
E
-----
LSDK
A
I
R
H
-
A
E
FL
AQ
-
DD
G
VI
HLL
H
V
L
P
G-
-
-S
ASL
S
L
HR
F
A
A
D
V
RRF
E
E
H
LQ
H
EA
EER
LQ
T
M
VS
H
F
T
I
DP
SR
IKQ
HV
R
F
GS
V
RD
E
V
N
ELA
K
E
L
D
A
D
VVVIGS
-
R
N
P
S
IST
H
LLGSNA
SS
VIRHA
N
L
P
VLVVR
fig|749546.3.peg.3436
Escherichia coli MS 185-1
M
YK
TI
IM
PVD
V
FEM
E
-----
LSDK
A
I
R
H
-
A
E
FL
AQ
-
DD
G
VI
HLL
H
V
L
P
G-
-
-S
ASL
S
L
HR
F
A
A
D
V
RRF
E
E
H
LQ
H
EA
EER
LQ
T
M
VS
H
F
T
I
DP
SR
IKQ
HV
R
F
GS
V
RD
E
V
N
ELA
K
E
L
D
A
D
VVVIGS
-
R
N
P
S
IST
H
LLGSNA
SS
VIRHA
N
L
P
VLVVR
fig|749550.3.peg.4837
Escherichia coli MS 200-1
M
YK
TI
IM
PVD
V
FEM
E
-----
LSDK
A
I
R
H
-
A
E
FL
AQ
-
DD
G
VI
HLL
H
V
L
P
G-
-
-S
ASL
S
L
HR
F
A
A
D
V
RRF
E
E
H
LQ
H
EA
EER
LQ
T
M
VS
H
F
T
I
DP
SR
IKQ
HV
R
F
GS
V
RD
E
V
N
ELA
K
E
L
D
A
D
VVVIGS
-
R
N
P
S
IST
H
LLGSNA
SS
VIRHA
N
L
P
VLVVR
fig|749528.3.peg.4025
Escherichia coli MS 45-1
M
YK
TI
IM
PVD
V
FEM
E
-----
LSDK
A
I
R
H
-
A
E
FL
AQ
-
DD
G
VI
HLL
H
V
L
P
G-
-
-S
ASL
S
L
HR
F
A
A
D
V
RRF
E
E
H
LQ
H
EA
EER
LQ
T
M
VS
H
F
T
I
DP
SR
IKQ
HV
R
F
GS
V
RD
E
V
N
ELA
K
E
L
D
A
D
VVVIGS
-
R
N
P
S
IST
H
LLGSNA
SS
VIRHA
N
L
P
VLVVR
fig|753642.3.peg.1046
Escherichia coli NC101
M
YK
TI
IM
PVD
V
FEM
E
-----
LSDK
A
I
R
H
-
A
E
FL
AQ
-
DD
G
VI
HLL
H
V
L
P
G-
-
-S
ASL
S
L
HR
F
A
A
D
V
RRF
E
E
H
LQ
H
EA
EER
LQ
T
M
VS
H
F
T
I
DP
SR
IKQ
HV
R
F
GS
V
RD
E
V
N
ELA
K
E
L
D
A
D
VVVIGS
-
R
N
P
S
IST
H
LLGSNA
SS
VIRHA
N
L
P
VLVVR
fig|574521.7.peg.549
Escherichia coli O127:H6 str. E2348/69
M
YK
TI
IM
PVD
V
FEM
E
-----
LSDK
A
I
R
H
-
A
E
FL
AQ
-
DD
G
VI
HLL
H
V
L
P
G-
-
-S
ASL
S
L
HR
F
A
A
D
V
RRF
E
E
H
LQ
H
EA
EER
LQ
T
M
VS
H
F
T
I
DP
SR
IKQ
HV
R
F
GS
V
RD
E
V
N
ELA
K
E
L
D
A
D
VVVIGS
-
R
N
P
S
IST
H
LLGSNA
SS
VIRHA
N
L
P
VLVVR
fig|685038.3.peg.555
Escherichia coli O83:H1 str. NRG 857C
M
YK
TI
IM
PVD
V
FEM
E
-----
LSDK
A
I
R
H
-
A
E
FL
AQ
-
DD
G
VI
HLL
H
V
L
P
G-
-
-S
ASL
S
L
HR
F
A
A
D
V
RRF
E
E
H
LQ
H
EA
EER
LQ
T
M
VS
H
F
T
I
DP
SR
IKQ
HV
R
F
GS
V
RD
E
V
N
ELA
K
E
L
D
A
D
VVVIGS
-
R
N
P
S
IST
H
LLGSNA
SS
VIRHA
N
L
P
VLVVR
fig|431946.3.peg.570
Escherichia coli SE15
M
YK
TI
IM
PVD
V
FEM
E
-----
LSDK
A
I
R
H
-
A
E
FL
AQ
-
DD
G
VI
HLL
H
V
L
P
G-
-
-S
ASL
S
L
HR
F
A
A
D
V
RRF
E
E
H
LQ
H
EA
EER
LQ
T
M
VS
H
F
T
I
DP
SR
IKQ
HV
R
F
GS
V
RD
E
V
N
ELA
K
E
L
D
A
D
VVVIGS
-
R
N
P
S
IST
H
LLGSNA
SS
VIRHA
N
L
P
VLVVR
fig|562.376.peg.2002
Escherichia coli WV_060327
M
YK
TI
IM
PVD
V
FEM
E
-----
LSDK
A
I
R
H
-
A
E
FL
AQ
-
DD
G
VI
HLL
H
V
L
P
G-
-
-S
ASL
S
L
HR
F
A
A
D
V
RRF
E
E
H
LQ
H
EA
EER
LQ
T
M
VS
H
F
T
I
DP
SR
IKQ
HV
R
F
GS
V
RD
E
V
N
ELA
K
E
L
D
A
D
VVVIGS
-
R
N
P
S
IST
H
LLGSNA
SS
VIRHA
N
L
P
VLVVR
fig|670897.3.peg.774
Escherichia coli 2362-75
M
YK
TI
IM
PVD
V
FEM
E
-----
LSDK
A
I
R
H
-
A
E
FL
AQ
-
DD
G
VI
HLL
H
V
L
P
G-
-
-S
ASL
S
L
HR
F
A
A
D
V
HRF
E
E
H
LQ
H
EA
EER
LQ
T
M
VS
H
F
T
I
DP
SR
IKQ
HV
R
F
GS
V
RD
E
V
N
ELA
K
E
L
D
A
D
VVVIGS
-
R
N
P
S
IST
H
LLGSNA
SS
VIRHA
N
L
P
VLVVR
fig|216592.3.peg.673
Escherichia coli 042
M
YK
TI
IM
PVD
V
FEM
E
-----
LSDK
A
V
R
H
-
A
E
FL
AQ
-
DD
G
VI
HLL
H
V
L
P
G-
-
-S
ASL
S
L
HR
F
A
A
D
V
RRF
E
E
H
LQ
H
EA
EER
LQ
T
M
VS
H
F
T
I
DP
SR
IKQ
HV
R
F
GS
V
RD
E
V
N
ELA
K
E
L
D
A
D
VVVIGS
-
R
N
P
S
IST
H
LLGSNA
SS
VIRHA
N
L
P
VLVVR
fig|405955.13.peg.588
Escherichia coli APEC O1
M
YK
TI
IM
PVD
V
FEM
E
-----
LSDK
A
V
R
H
-
A
E
FL
AQ
-
DD
G
VI
HLL
H
V
L
P
G-
-
-S
ASL
S
L
HR
F
A
A
D
V
RRF
E
E
H
LQ
H
EA
EER
LQ
T
M
VS
H
F
T
I
DP
SR
IKQ
HV
R
F
GS
V
RD
E
V
N
ELA
K
E
L
D
A
D
VVVIGS
-
R
N
P
S
IST
H
LLGSNA
SS
VIRHA
N
L
P
VLVVR
fig|550677.3.peg.1029
Escherichia coli B354
M
YK
TI
IM
PVD
V
FEM
E
-----
LSDK
A
V
R
H
-
A
E
FL
AQ
-
DD
G
VI
HLL
H
V
L
P
G-
-
-S
ASL
S
L
HR
F
A
A
D
V
RRF
E
E
H
LQ
H
EA
EER
LQ
T
M
VS
H
F
T
I
DP
SR
IKQ
HV
R
F
GS
V
RD
E
V
N
ELA
K
E
L
D
A
D
VVVIGS
-
R
N
P
S
IST
H
LLGSNA
SS
VIRHA
N
L
P
VLVVR
fig|585057.4.peg.624
Escherichia coli IAI39
M
YK
TI
IM
PVD
V
FEM
E
-----
LSDK
A
V
R
H
-
A
E
FL
AQ
-
DD
G
VI
HLL
H
V
L
P
G-
-
-S
ASL
S
L
HR
F
A
A
D
V
RRF
E
E
H
LQ
H
EA
EER
LQ
T
M
VS
H
F
T
I
DP
SR
IKQ
HV
R
F
GS
V
RD
E
V
N
ELA
K
E
L
D
A
D
VVVIGS
-
R
N
P
S
IST
H
LLGSNA
SS
VIRHA
N
L
P
VLVVR
fig|585057.6.peg.622
Escherichia coli IAI39
M
YK
TI
IM
PVD
V
FEM
E
-----
LSDK
A
V
R
H
-
A
E
FL
AQ
-
DD
G
VI
HLL
H
V
L
P
G-
-
-S
ASL
S
L
HR
F
A
A
D
V
RRF
E
E
H
LQ
H
EA
EER
LQ
T
M
VS
H
F
T
I
DP
SR
IKQ
HV
R
F
GS
V
RD
E
V
N
ELA
K
E
L
D
A
D
VVVIGS
-
R
N
P
S
IST
H
LLGSNA
SS
VIRHA
N
L
P
VLVVR
fig|714962.3.peg.636
Escherichia coli IHE3034
M
YK
TI
IM
PVD
V
FEM
E
-----
LSDK
A
V
R
H
-
A
E
FL
AQ
-
DD
G
VI
HLL
H
V
L
P
G-
-
-S
ASL
S
L
HR
F
A
A
D
V
RRF
E
E
H
LQ
H
EA
EER
LQ
T
M
VS
H
F
T
I
DP
SR
IKQ
HV
R
F
GS
V
RD
E
V
N
ELA
K
E
L
D
A
D
VVVIGS
-
R
N
P
S
IST
H
LLGSNA
SS
VIRHA
N
L
P
VLVVR
fig|749527.3.peg.4193
Escherichia coli MS 21-1
M
YK
TI
IM
PVD
V
FEM
E
-----
LSDK
A
V
R
H
-
A
E
FL
AQ
-
DD
G
VI
HLL
H
V
L
P
G-
-
-S
ASL
S
L
HR
F
A
A
D
V
RRF
E
E
H
LQ
H
EA
EER
LQ
T
M
VS
H
F
T
I
DP
SR
IKQ
HV
R
F
GS
V
RD
E
V
N
ELA
K
E
L
D
A
D
VVVIGS
-
R
N
P
S
IST
H
LLGSNA
SS
VIRHA
N
L
P
VLVVR
fig|585035.6.peg.645
Escherichia coli S88
M
YK
TI
IM
PVD
V
FEM
E
-----
LSDK
A
V
R
H
-
A
E
FL
AQ
-
DD
G
VI
HLL
H
V
L
P
G-
-
-S
ASL
S
L
HR
F
A
A
D
V
RRF
E
E
H
LQ
H
EA
EER
LQ
T
M
VS
H
F
T
I
DP
SR
IKQ
HV
R
F
GS
V
RD
E
V
N
ELA
K
E
L
D
A
D
VVVIGS
-
R
N
P
S
IST
H
LLGSNA
SS
VIRHA
N
L
P
VLVVR
fig|439855.10.peg.798
Escherichia coli SMS-3-5
M
YK
TI
IM
PVD
V
FEM
E
-----
LSDK
A
V
R
H
-
A
E
FL
AQ
-
DD
G
VI
HLL
H
V
L
P
G-
-
-S
ASL
S
L
HR
F
A
A
D
V
RRF
E
E
H
LQ
H
EA
EER
LQ
T
M
VS
H
F
T
I
DP
SR
IKQ
HV
R
F
GS
V
RD
E
V
N
ELA
K
E
L
D
A
D
VVVIGS
-
R
N
P
S
IST
H
LLGSNA
SS
VIRHA
N
L
P
VLVVR
fig|656437.3.peg.687
Escherichia coli TA143
M
YK
TI
IM
PVD
V
FEM
E
-----
LSDK
A
V
R
H
-
A
E
FL
AQ
-
DD
G
VI
HLL
H
V
L
P
G-
-
-S
ASL
S
L
HR
F
A
A
D
V
RRF
E
E
H
LQ
H
EA
EER
LQ
T
M
VS
H
F
T
I
DP
SR
IKQ
HV
R
F
GS
V
RD
E
V
N
ELA
K
E
L
D
A
D
VVVIGS
-
R
N
P
S
IST
H
LLGSNA
SS
VIRHA
N
L
P
VLVVR
fig|656440.3.peg.468
Escherichia coli TA206
M
YK
TI
IM
PVD
V
FEM
E
-----
LSDK
A
V
R
H
-
A
E
FL
AQ
-
DD
G
VI
HLL
H
V
L
P
G-
-
-S
ASL
S
L
HR
F
A
A
D
V
RRF
E
E
H
LQ
H
EA
EER
LQ
T
M
VS
H
F
T
I
DP
SR
IKQ
HV
R
F
GS
V
RD
E
V
N
ELA
K
E
L
D
A
D
VVVIGS
-
R
N
P
S
IST
H
LLGSNA
SS
VIRHA
N
L
P
VLVVR
fig|656444.3.peg.1148
Escherichia coli TA280
M
YK
TI
IM
PVD
V
FEM
E
-----
LSDK
A
V
R
H
-
A
E
FL
AQ
-
DD
G
VI
HLL
H
V
L
P
G-
-
-S
ASL
S
L
HR
F
A
A
D
V
RRF
E
E
H
LQ
H
EA
EER
LQ
T
M
VS
H
F
T
I
DP
SR
IKQ
HV
R
F
GS
V
RD
E
V
N
ELA
K
E
L
D
A
D
VVVIGS
-
R
N
P
S
IST
H
LLGSNA
SS
VIRHA
N
L
P
VLVVR
fig|869729.3.peg.3094
Escherichia coli UM146
M
YK
TI
IM
PVD
V
FEM
E
-----
LSDK
A
V
R
H
-
A
E
FL
AQ
-
DD
G
VI
HLL
H
V
L
P
G-
-
-S
ASL
S
L
HR
F
A
A
D
V
RRF
E
E
H
LQ
H
EA
EER
LQ
T
M
VS
H
F
T
I
DP
SR
IKQ
HV
R
F
GS
V
RD
E
V
N
ELA
K
E
L
D
A
D
VVVIGS
-
R
N
P
S
IST
H
LLGSNA
SS
VIRHA
N
L
P
VLVVR
fig|364106.7.peg.717
Escherichia coli UTI89
M
YK
TI
IM
PVD
V
FEM
E
-----
LSDK
A
V
R
H
-
A
E
FL
AQ
-
DD
G
VI
HLL
H
V
L
P
G-
-
-S
ASL
S
L
HR
F
A
A
D
V
RRF
E
E
H
LQ
H
EA
EER
LQ
T
M
VS
H
F
T
I
DP
SR
IKQ
HV
R
F
GS
V
RD
E
V
N
ELA
K
E
L
D
A
D
VVVIGS
-
R
N
P
S
IST
H
LLGSNA
SS
VIRHA
N
L
P
VLVVR
fig|364106.8.peg.714
Escherichia coli UTI89
M
YK
TI
IM
PVD
V
FEM
E
-----
LSDK
A
V
R
H
-
A
E
FL
AQ
-
DD
G
VI
HLL
H
V
L
P
G-
-
-S
ASL
S
L
HR
F
A
A
D
V
RRF
E
E
H
LQ
H
EA
EER
LQ
T
M
VS
H
F
T
I
DP
SR
IKQ
HV
R
F
GS
V
RD
E
V
N
ELA
K
E
L
D
A
D
VVVIGS
-
R
N
P
S
IST
H
LLGSNA
SS
VIRHA
N
L
P
VLVVR
fig|358709.5.peg.1940
Escherichia coli 101-1
M
YK
TI
IM
PVD
V
FEM
E
-----
LSDK
A
V
R
H
-
A
E
FL
AQ
-
DD
G
VI
HLL
H
V
L
P
G-
-
-S
ASL
S
L
HR
F
A
A
D
V
RRF
E
E
H
LQ
H
EA
QER
LQ
T
M
VS
H
F
T
I
DP
SR
IKQ
HV
R
F
GS
V
RD
E
V
N
ELAE
E
L
G
A
D
VVVIGS
-
R
N
P
S
IST
H
LLGSNA
SS
VIRHA
N
L
P
VLVVR
fig|344610.3.peg.1596
Escherichia coli 53638
M
YK
TI
IM
PVD
V
FEM
E
-----
LSDK
A
V
R
H
-
A
E
FL
AQ
-
DD
G
VI
HLL
H
V
L
P
G-
-
-S
ASL
S
L
HR
F
A
A
D
V
RRF
E
E
H
LQ
H
EA
QER
LQ
T
M
VS
H
F
T
I
DP
SR
IKQ
HV
R
F
GS
V
RD
E
V
N
ELAE
E
L
G
A
D
VVVIGS
-
R
N
P
S
IST
H
LLGSNA
SS
VIRHA
N
L
P
VLVVR
fig|481805.3.peg.3257
Escherichia coli ATCC 8739
M
YK
TI
IM
PVD
V
FEM
E
-----
LSDK
A
V
R
H
-
A
E
FL
AQ
-
DD
G
VI
HLL
H
V
L
P
G-
-
-S
ASL
S
L
HR
F
A
A
D
V
RRF
E
E
H
LQ
H
EA
QER
LQ
T
M
VS
H
F
T
I
DP
SR
IKQ
HV
R
F
GS
V
RD
E
V
N
ELAE
E
L
G
A
D
VVVIGS
-
R
N
P
S
IST
H
LLGSNA
SS
VIRHA
N
L
P
VLVVR
fig|481805.6.peg.3243
Escherichia coli ATCC 8739
M
YK
TI
IM
PVD
V
FEM
E
-----
LSDK
A
V
R
H
-
A
E
FL
AQ
-
DD
G
VI
HLL
H
V
L
P
G-
-
-S
ASL
S
L
HR
F
A
A
D
V
RRF
E
E
H
LQ
H
EA
QER
LQ
T
M
VS
H
F
T
I
DP
SR
IKQ
HV
R
F
GS
V
RD
E
V
N
ELAE
E
L
G
A
D
VVVIGS
-
R
N
P
S
IST
H
LLGSNA
SS
VIRHA
N
L
P
VLVVR
fig|413997.3.peg.606
Escherichia coli B str. REL606
M
YK
TI
IM
PVD
V
FEM
E
-----
LSDK
A
V
R
H
-
A
E
FL
AQ
-
DD
G
VI
HLL
H
V
L
P
G-
-
-S
ASL
S
L
HR
F
A
A
D
V
RRF
E
E
H
LQ
H
EA
QER
LQ
T
M
VS
H
F
T
I
DP
SR
IKQ
HV
R
F
GS
V
RD
E
V
N
ELAE
E
L
G
A
D
VVVIGS
-
R
N
P
S
IST
H
LLGSNA
SS
VIRHA
N
L
P
VLVVR
fig|511693.5.peg.602
Escherichia coli BL21
M
YK
TI
IM
PVD
V
FEM
E
-----
LSDK
A
V
R
H
-
A
E
FL
AQ
-
DD
G
VI
HLL
H
V
L
P
G-
-
-S
ASL
S
L
HR
F
A
A
D
V
RRF
E
E
H
LQ
H
EA
QER
LQ
T
M
VS
H
F
T
I
DP
SR
IKQ
HV
R
F
GS
V
RD
E
V
N
ELAE
E
L
G
A
D
VVVIGS
-
R
N
P
S
IST
H
LLGSNA
SS
VIRHA
N
L
P
VLVVR
fig|469008.4.peg.3153
Escherichia coli BL21(DE3)
M
YK
TI
IM
PVD
V
FEM
E
-----
LSDK
A
V
R
H
-
A
E
FL
AQ
-
DD
G
VI
HLL
H
V
L
P
G-
-
-S
ASL
S
L
HR
F
A
A
D
V
RRF
E
E
H
LQ
H
EA
QER
LQ
T
M
VS
H
F
T
I
DP
SR
IKQ
HV
R
F
GS
V
RD
E
V
N
ELAE
E
L
G
A
D
VVVIGS
-
R
N
P
S
IST
H
LLGSNA
SS
VIRHA
N
L
P
VLVVR
fig|595496.3.peg.533
Escherichia coli BW2952
M
YK
TI
IM
PVD
V
FEM
E
-----
LSDK
A
V
R
H
-
A
E
FL
AQ
-
DD
G
VI
HLL
H
V
L
P
G-
-
-S
ASL
S
L
HR
F
A
A
D
V
RRF
E
E
H
LQ
H
EA
QER
LQ
T
M
VS
H
F
T
I
DP
SR
IKQ
HV
R
F
GS
V
RD
E
V
N
ELAE
E
L
G
A
D
VVVIGS
-
R
N
P
S
IST
H
LLGSNA
SS
VIRHA
N
L
P
VLVVR
fig|536056.3.peg.3190
Escherichia coli DH1
M
YK
TI
IM
PVD
V
FEM
E
-----
LSDK
A
V
R
H
-
A
E
FL
AQ
-
DD
G
VI
HLL
H
V
L
P
G-
-
-S
ASL
S
L
HR
F
A
A
D
V
RRF
E
E
H
LQ
H
EA
QER
LQ
T
M
VS
H
F
T
I
DP
SR
IKQ
HV
R
F
GS
V
RD
E
V
N
ELAE
E
L
G
A
D
VVVIGS
-
R
N
P
S
IST
H
LLGSNA
SS
VIRHA
N
L
P
VLVVR
fig|316401.4.peg.731
Escherichia coli ETEC H10407
M
YK
TI
IM
PVD
V
FEM
E
-----
LSDK
A
V
R
H
-
A
E
FL
AQ
-
DD
G
VI
HLL
H
V
L
P
G-
-
-S
ASL
S
L
HR
F
A
A
D
V
RRF
E
E
H
LQ
H
EA
QER
LQ
T
M
VS
H
F
T
I
DP
SR
IKQ
HV
R
F
GS
V
RD
E
V
N
ELAE
E
L
G
A
D
VVVIGS
-
R
N
P
S
IST
H
LLGSNA
SS
VIRHA
N
L
P
VLVVR
fig|656414.3.peg.785
Escherichia coli H736
M
YK
TI
IM
PVD
V
FEM
E
-----
LSDK
A
V
R
H
-
A
E
FL
AQ
-
DD
G
VI
HLL
H
V
L
P
G-
-
-S
ASL
S
L
HR
F
A
A
D
V
RRF
E
E
H
LQ
H
EA
QER
LQ
T
M
VS
H
F
T
I
DP
SR
IKQ
HV
R
F
GS
V
RD
E
V
N
ELAE
E
L
G
A
D
VVVIGS
-
R
N
P
S
IST
H
LLGSNA
SS
VIRHA
N
L
P
VLVVR
fig|83333.1.peg.608
Escherichia coli K12
M
YK
TI
IM
PVD
V
FEM
E
-----
LSDK
A
V
R
H
-
A
E
FL
AQ
-
DD
G
VI
HLL
H
V
L
P
G-
-
-S
ASL
S
L
HR
F
A
A
D
V
RRF
E
E
H
LQ
H
EA
QER
LQ
T
M
VS
H
F
T
I
DP
SR
IKQ
HV
R
F
GS
V
RD
E
V
N
ELAE
E
L
G
A
D
VVVIGS
-
R
N
P
S
IST
H
LLGSNA
SS
VIRHA
N
L
P
VLVVR
fig|749538.3.peg.4216
Escherichia coli MS 116-1
M
YK
TI
IM
PVD
V
FEM
E
-----
LSDK
A
V
R
H
-
A
E
FL
AQ
-
DD
G
VI
HLL
H
V
L
P
G-
-
-S
ASL
S
L
HR
F
A
A
D
V
RRF
E
E
H
LQ
H
EA
QER
LQ
T
M
VS
H
F
T
I
DP
SR
IKQ
HV
R
F
GS
V
RD
E
V
N
ELAE
E
L
G
A
D
VVVIGS
-
R
N
P
S
IST
H
LLGSNA
SS
VIRHA
N
L
P
VLVVR
fig|749540.3.peg.629
Escherichia coli MS 146-1
M
YK
TI
IM
PVD
V
FEM
E
-----
LSDK
A
V
R
H
-
A
E
FL
AQ
-
DD
G
VI
HLL
H
V
L
P
G-
-
-S
ASL
S
L
HR
F
A
A
D
V
RRF
E
E
H
LQ
H
EA
QER
LQ
T
M
VS
H
F
T
I
DP
SR
IKQ
HV
R
F
GS
V
RD
E
V
N
ELAE
E
L
G
A
D
VVVIGS
-
R
N
P
S
IST
H
LLGSNA
SS
VIRHA
N
L
P
VLVVR
fig|749547.3.peg.3603
Escherichia coli MS 187-1
M
YK
TI
IM
PVD
V
FEM
E
-----
LSDK
A
V
R
H
-
A
E
FL
AQ
-
DD
G
VI
HLL
H
V
L
P
G-
-
-S
ASL
S
L
HR
F
A
A
D
V
RRF
E
E
H
LQ
H
EA
QER
LQ
T
M
VS
H
F
T
I
DP
SR
IKQ
HV
R
F
GS
V
RD
E
V
N
ELAE
E
L
G
A
D
VVVIGS
-
R
N
P
S
IST
H
LLGSNA
SS
VIRHA
N
L
P
VLVVR
fig|637912.3.peg.1408
Escherichia coli OP50
M
YK
TI
IM
PVD
V
FEM
E
-----
LSDK
A
V
R
H
-
A
E
FL
AQ
-
DD
G
VI
HLL
H
V
L
P
G-
-
-S
ASL
S
L
HR
F
A
A
D
V
RRF
E
E
H
LQ
H
EA
QER
LQ
T
M
VS
H
F
T
I
DP
SR
IKQ
HV
R
F
GS
V
RD
E
V
N
ELAE
E
L
G
A
D
VVVIGS
-
R
N
P
S
IST
H
LLGSNA
SS
VIRHA
N
L
P
VLVVR
fig|316407.3.peg.591
Escherichia coli W3110
M
YK
TI
IM
PVD
V
FEM
E
-----
LSDK
A
V
R
H
-
A
E
FL
AQ
-
DD
G
VI
HLL
H
V
L
P
G-
-
-S
ASL
S
L
HR
F
A
A
D
V
RRF
E
E
H
LQ
H
EA
QER
LQ
T
M
VS
H
F
T
I
DP
SR
IKQ
HV
R
F
GS
V
RD
E
V
N
ELAE
E
L
G
A
D
VVVIGS
-
R
N
P
S
IST
H
LLGSNA
SS
VIRHA
N
L
P
VLVVR
fig|316385.7.peg.572
Escherichia coli str. K-12 substr. DH10B
M
YK
TI
IM
PVD
V
FEM
E
-----
LSDK
A
V
R
H
-
A
E
FL
AQ
-
DD
G
VI
HLL
H
V
L
P
G-
-
-S
ASL
S
L
HR
F
A
A
D
V
RRF
E
E
H
LQ
H
EA
QER
LQ
T
M
VS
H
F
T
I
DP
SR
IKQ
HV
R
F
GS
V
RD
E
V
N
ELAE
E
L
G
A
D
VVVIGS
-
R
N
P
S
IST
H
LLGSNA
SS
VIRHA
N
L
P
VLVVR
fig|316385.7.peg.683
Escherichia coli str. K-12 substr. DH10B
M
YK
TI
IM
PVD
V
FEM
E
-----
LSDK
A
V
R
H
-
A
E
FL
AQ
-
DD
G
VI
HLL
H
V
L
P
G-
-
-S
ASL
S
L
HR
F
A
A
D
V
RRF
E
E
H
LQ
H
EA
QER
LQ
T
M
VS
H
F
T
I
DP
SR
IKQ
HV
R
F
GS
V
RD
E
V
N
ELAE
E
L
G
A
D
VVVIGS
-
R
N
P
S
IST
H
LLGSNA
SS
VIRHA
N
L
P
VLVVR
fig|511145.12.peg.637
Escherichia coli str. K-12 substr. MG1655
M
YK
TI
IM
PVD
V
FEM
E
-----
LSDK
A
V
R
H
-
A
E
FL
AQ
-
DD
G
VI
HLL
H
V
L
P
G-
-
-S
ASL
S
L
HR
F
A
A
D
V
RRF
E
E
H
LQ
H
EA
QER
LQ
T
M
VS
H
F
T
I
DP
SR
IKQ
HV
R
F
GS
V
RD
E
V
N
ELAE
E
L
G
A
D
VVVIGS
-
R
N
P
S
IST
H
LLGSNA
SS
VIRHA
N
L
P
VLVVR
fig|511145.6.peg.628
Escherichia coli str. K-12 substr. MG1655
M
YK
TI
IM
PVD
V
FEM
E
-----
LSDK
A
V
R
H
-
A
E
FL
AQ
-
DD
G
VI
HLL
H
V
L
P
G-
-
-S
ASL
S
L
HR
F
A
A
D
V
RRF
E
E
H
LQ
H
EA
QER
LQ
T
M
VS
H
F
T
I
DP
SR
IKQ
HV
R
F
GS
V
RD
E
V
N
ELAE
E
L
G
A
D
VVVIGS
-
R
N
P
S
IST
H
LLGSNA
SS
VIRHA
N
L
P
VLVVR
fig|1040638.4.peg.5300
Escherichia coli O104:H4 str. LB226692
M
YK
TI
IM
PVD
V
FEM
E
-----
LSDK
A
V
R
H
-
A
E
FL
AQ
-
DD
G
VI
HLL
H
V
L
P
G-
-
-S
ASL
S
L
HR
F
A
A
D
V
RRF
E
E
H
LQ
H
EA
EER
LQ
T
M
VS
H
F
T
I
DP
SR
IKQ
HV
R
F
GS
V
RD
E
V
N
ELAE
E
L
G
A
D
VVVIGS
-
R
N
P
S
IST
H
LLGSNA
SS
VIRHA
N
L
P
VLVVR
fig|6666666.5357.peg.400
Escherichia coli TY-2482
M
YK
TI
IM
PVD
V
FEM
E
-----
LSDK
A
V
R
H
-
A
E
FL
AQ
-
DD
G
VI
HLL
H
V
L
P
G-
-
-S
ASL
S
L
HR
F
A
A
D
V
RRF
E
E
H
LQ
H
EA
EER
LQ
T
M
VS
H
F
T
I
DP
SR
IKQ
HV
R
F
GS
V
RD
E
V
N
ELAE
E
L
G
A
D
VVVIGS
-
R
N
P
S
IST
H
LLGSNA
SS
VIRHA
N
L
P
VLVVR
fig|562.371.peg.2865
Escherichia coli 1044A
M
YK
TI
IM
PVD
V
FEM
E
-----
LSDK
A
V
R
H
-
A
E
FL
AQ
-
DD
G
VI
HLL
H
V
L
P
G-
-
-S
ASL
S
L
HR
F
A
A
D
V
RRF
E
E
H
LQ
H
EA
EER
LQ
T
M
VS
H
F
T
I
DP
SR
IKQ
HV
R
F
GS
V
RD
E
V
N
ELAE
E
L
G
A
D
VVVIGS
-
R
N
P
S
IST
H
LLGSNA
SS
VIRHA
N
L
P
VLVVR
fig|562.372.peg.1596
Escherichia coli 1212A
M
YK
TI
IM
PVD
V
FEM
E
-----
LSDK
A
V
R
H
-
A
E
FL
AQ
-
DD
G
VI
HLL
H
V
L
P
G-
-
-S
ASL
S
L
HR
F
A
A
D
V
RRF
E
E
H
LQ
H
EA
EER
LQ
T
M
VS
H
F
T
I
DP
SR
IKQ
HV
R
F
GS
V
RD
E
V
N
ELAE
E
L
G
A
D
VVVIGS
-
R
N
P
S
IST
H
LLGSNA
SS
VIRHA
N
L
P
VLVVR
fig|670888.3.peg.1175
Escherichia coli 1827-70
M
YK
TI
IM
PVD
V
FEM
E
-----
LSDK
A
V
R
H
-
A
E
FL
AQ
-
DD
G
VI
HLL
H
V
L
P
G-
-
-S
ASL
S
L
HR
F
A
A
D
V
RRF
E
E
H
LQ
H
EA
EER
LQ
T
M
VS
H
F
T
I
DP
SR
IKQ
HV
R
F
GS
V
RD
E
V
N
ELAE
E
L
G
A
D
VVVIGS
-
R
N
P
S
IST
H
LLGSNA
SS
VIRHA
N
L
P
VLVVR
fig|585055.6.peg.611
Escherichia coli 55989
M
YK
TI
IM
PVD
V
FEM
E
-----
LSDK
A
V
R
H
-
A
E
FL
AQ
-
DD
G
VI
HLL
H
V
L
P
G-
-
-S
ASL
S
L
HR
F
A
A
D
V
RRF
E
E
H
LQ
H
EA
EER
LQ
T
M
VS
H
F
T
I
DP
SR
IKQ
HV
R
F
GS
V
RD
E
V
N
ELAE
E
L
G
A
D
VVVIGS
-
R
N
P
S
IST
H
LLGSNA
SS
VIRHA
N
L
P
VLVVR
fig|585055.8.peg.612
Escherichia coli 55989
M
YK
TI
IM
PVD
V
FEM
E
-----
LSDK
A
V
R
H
-
A
E
FL
AQ
-
DD
G
VI
HLL
H
V
L
P
G-
-
-S
ASL
S
L
HR
F
A
A
D
V
RRF
E
E
H
LQ
H
EA
EER
LQ
T
M
VS
H
F
T
I
DP
SR
IKQ
HV
R
F
GS
V
RD
E
V
N
ELAE
E
L
G
A
D
VVVIGS
-
R
N
P
S
IST
H
LLGSNA
SS
VIRHA
N
L
P
VLVVR
fig|344601.3.peg.2262
Escherichia coli B171
M
YK
TI
IM
PVD
V
FEM
E
-----
LSDK
A
V
R
H
-
A
E
FL
AQ
-
DD
G
VI
HLL
H
V
L
P
G-
-
-S
ASL
S
L
HR
F
A
A
D
V
RRF
E
E
H
LQ
H
EA
EER
LQ
T
M
VS
H
F
T
I
DP
SR
IKQ
HV
R
F
GS
V
RD
E
V
N
ELAE
E
L
G
A
D
VVVIGS
-
R
N
P
S
IST
H
LLGSNA
SS
VIRHA
N
L
P
VLVVR
fig|344601.5.peg.2364
Escherichia coli B171
M
YK
TI
IM
PVD
V
FEM
E
-----
LSDK
A
V
R
H
-
A
E
FL
AQ
-
DD
G
VI
HLL
H
V
L
P
G-
-
-S
ASL
S
L
HR
F
A
A
D
V
RRF
E
E
H
LQ
H
EA
EER
LQ
T
M
VS
H
F
T
I
DP
SR
IKQ
HV
R
F
GS
V
RD
E
V
N
ELAE
E
L
G
A
D
VVVIGS
-
R
N
P
S
IST
H
LLGSNA
SS
VIRHA
N
L
P
VLVVR
fig|550676.3.peg.74
Escherichia coli B185
M
YK
TI
IM
PVD
V
FEM
E
-----
LSDK
A
V
R
H
-
A
E
FL
AQ
-
DD
G
VI
HLL
H
V
L
P
G-
-
-S
ASL
S
L
HR
F
A
A
D
V
RRF
E
E
H
LQ
H
EA
EER
LQ
T
M
VS
H
F
T
I
DP
SR
IKQ
HV
R
F
GS
V
RD
E
V
N
ELAE
E
L
G
A
D
VVVIGS
-
R
N
P
S
IST
H
LLGSNA
SS
VIRHA
N
L
P
VLVVR
fig|340184.3.peg.2432
Escherichia coli B7A
M
YK
TI
IM
PVD
V
FEM
E
-----
LSDK
A
V
R
H
-
A
E
FL
AQ
-
DD
G
VI
HLL
H
V
L
P
G-
-
-S
ASL
S
L
HR
F
A
A
D
V
RRF
E
E
H
LQ
H
EA
EER
LQ
T
M
VS
H
F
T
I
DP
SR
IKQ
HV
R
F
GS
V
RD
E
V
N
ELAE
E
L
G
A
D
VVVIGS
-
R
N
P
S
IST
H
LLGSNA
SS
VIRHA
N
L
P
VLVVR
fig|340184.6.peg.2551
Escherichia coli B7A
M
YK
TI
IM
PVD
V
FEM
E
-----
LSDK
A
V
R
H
-
A
E
FL
AQ
-
DD
G
VI
HLL
H
V
L
P
G-
-
-S
ASL
S
L
HR
F
A
A
D
V
RRF
E
E
H
LQ
H
EA
EER
LQ
T
M
VS
H
F
T
I
DP
SR
IKQ
HV
R
F
GS
V
RD
E
V
N
ELAE
E
L
G
A
D
VVVIGS
-
R
N
P
S
IST
H
LLGSNA
SS
VIRHA
N
L
P
VLVVR
fig|340186.3.peg.2261
Escherichia coli E110019
M
YK
TI
IM
PVD
V
FEM
E
-----
LSDK
A
V
R
H
-
A
E
FL
AQ
-
DD
G
VI
HLL
H
V
L
P
G-
-
-S
ASL
S
L
HR
F
A
A
D
V
RRF
E
E
H
LQ
H
EA
EER
LQ
T
M
VS
H
F
T
I
DP
SR
IKQ
HV
R
F
GS
V
RD
E
V
N
ELAE
E
L
G
A
D
VVVIGS
-
R
N
P
S
IST
H
LLGSNA
SS
VIRHA
N
L
P
VLVVR
fig|340186.5.peg.2335
Escherichia coli E110019
M
YK
TI
IM
PVD
V
FEM
E
-----
LSDK
A
V
R
H
-
A
E
FL
AQ
-
DD
G
VI
HLL
H
V
L
P
G-
-
-S
ASL
S
L
HR
F
A
A
D
V
RRF
E
E
H
LQ
H
EA
EER
LQ
T
M
VS
H
F
T
I
DP
SR
IKQ
HV
R
F
GS
V
RD
E
V
N
ELAE
E
L
G
A
D
VVVIGS
-
R
N
P
S
IST
H
LLGSNA
SS
VIRHA
N
L
P
VLVVR
fig|340185.3.peg.1728
Escherichia coli E22
M
YK
TI
IM
PVD
V
FEM
E
-----
LSDK
A
V
R
H
-
A
E
FL
AQ
-
DD
G
VI
HLL
H
V
L
P
G-
-
-S
ASL
S
L
HR
F
A
A
D
V
RRF
E
E
H
LQ
H
EA
EER
LQ
T
M
VS
H
F
T
I
DP
SR
IKQ
HV
R
F
GS
V
RD
E
V
N
ELAE
E
L
G
A
D
VVVIGS
-
R
N
P
S
IST
H
LLGSNA
SS
VIRHA
N
L
P
VLVVR
fig|340185.4.peg.1822
Escherichia coli E22
M
YK
TI
IM
PVD
V
FEM
E
-----
LSDK
A
V
R
H
-
A
E
FL
AQ
-
DD
G
VI
HLL
H
V
L
P
G-
-
-S
ASL
S
L
HR
F
A
A
D
V
RRF
E
E
H
LQ
H
EA
EER
LQ
T
M
VS
H
F
T
I
DP
SR
IKQ
HV
R
F
GS
V
RD
E
V
N
ELAE
E
L
G
A
D
VVVIGS
-
R
N
P
S
IST
H
LLGSNA
SS
VIRHA
N
L
P
VLVVR
fig|331111.12.peg.935
Escherichia coli E24377A
M
YK
TI
IM
PVD
V
FEM
E
-----
LSDK
A
V
R
H
-
A
E
FL
AQ
-
DD
G
VI
HLL
H
V
L
P
G-
-
-S
ASL
S
L
HR
F
A
A
D
V
RRF
E
E
H
LQ
H
EA
EER
LQ
T
M
VS
H
F
T
I
DP
SR
IKQ
HV
R
F
GS
V
RD
E
V
N
ELAE
E
L
G
A
D
VVVIGS
-
R
N
P
S
IST
H
LLGSNA
SS
VIRHA
N
L
P
VLVVR
fig|331111.3.peg.3158
Escherichia coli E24377A
M
YK
TI
IM
PVD
V
FEM
E
-----
LSDK
A
V
R
H
-
A
E
FL
AQ
-
DD
G
VI
HLL
H
V
L
P
G-
-
-S
ASL
S
L
HR
F
A
A
D
V
RRF
E
E
H
LQ
H
EA
EER
LQ
T
M
VS
H
F
T
I
DP
SR
IKQ
HV
R
F
GS
V
RD
E
V
N
ELAE
E
L
G
A
D
VVVIGS
-
R
N
P
S
IST
H
LLGSNA
SS
VIRHA
N
L
P
VLVVR
fig|562.375.peg.1548
Escherichia coli EC4100B
M
YK
TI
IM
PVD
V
FEM
E
-----
LSDK
A
V
R
H
-
A
E
FL
AQ
-
DD
G
VI
HLL
H
V
L
P
G-
-
-S
ASL
S
L
HR
F
A
A
D
V
RRF
E
E
H
LQ
H
EA
EER
LQ
T
M
VS
H
F
T
I
DP
SR
IKQ
HV
R
F
GS
V
RD
E
V
N
ELAE
E
L
G
A
D
VVVIGS
-
R
N
P
S
IST
H
LLGSNA
SS
VIRHA
N
L
P
VLVVR
fig|656379.3.peg.1392
Escherichia coli FVEC1302
M
YK
TI
IM
PVD
V
FEM
E
-----
LSDK
A
V
R
H
-
A
E
FL
AQ
-
DD
G
VI
HLL
H
V
L
P
G-
-
-S
ASL
S
L
HR
F
A
A
D
V
RRF
E
E
H
LQ
H
EA
EER
LQ
T
M
VS
H
F
T
I
DP
SR
IKQ
HV
R
F
GS
V
RD
E
V
N
ELAE
E
L
G
A
D
VVVIGS
-
R
N
P
S
IST
H
LLGSNA
SS
VIRHA
N
L
P
VLVVR
fig|656380.3.peg.1219
Escherichia coli FVEC1412
M
YK
TI
IM
PVD
V
FEM
E
-----
LSDK
A
V
R
H
-
A
E
FL
AQ
-
DD
G
VI
HLL
H
V
L
P
G-
-
-S
ASL
S
L
HR
F
A
A
D
V
RRF
E
E
H
LQ
H
EA
EER
LQ
T
M
VS
H
F
T
I
DP
SR
IKQ
HV
R
F
GS
V
RD
E
V
N
ELAE
E
L
G
A
D
VVVIGS
-
R
N
P
S
IST
H
LLGSNA
SS
VIRHA
N
L
P
VLVVR
fig|656408.3.peg.544
Escherichia coli H591
M
YK
TI
IM
PVD
V
FEM
E
-----
LSDK
A
V
R
H
-
A
E
FL
AQ
-
DD
G
VI
HLL
H
V
L
P
G-
-
-S
ASL
S
L
HR
F
A
A
D
V
RRF
E
E
H
LQ
H
EA
EER
LQ
T
M
VS
H
F
T
I
DP
SR
IKQ
HV
R
F
GS
V
RD
E
V
N
ELAE
E
L
G
A
D
VVVIGS
-
R
N
P
S
IST
H
LLGSNA
SS
VIRHA
N
L
P
VLVVR
fig|331112.3.peg.615
Escherichia coli HS
M
YK
TI
IM
PVD
V
FEM
E
-----
LSDK
A
V
R
H
-
A
E
FL
AQ
-
DD
G
VI
HLL
H
V
L
P
G-
-
-S
ASL
S
L
HR
F
A
A
D
V
RRF
E
E
H
LQ
H
EA
EER
LQ
T
M
VS
H
F
T
I
DP
SR
IKQ
HV
R
F
GS
V
RD
E
V
N
ELAE
E
L
G
A
D
VVVIGS
-
R
N
P
S
IST
H
LLGSNA
SS
VIRHA
N
L
P
VLVVR
fig|331112.6.peg.643
Escherichia coli HS
M
YK
TI
IM
PVD
V
FEM
E
-----
LSDK
A
V
R
H
-
A
E
FL
AQ
-
DD
G
VI
HLL
H
V
L
P
G-
-
-S
ASL
S
L
HR
F
A
A
D
V
RRF
E
E
H
LQ
H
EA
EER
LQ
T
M
VS
H
F
T
I
DP
SR
IKQ
HV
R
F
GS
V
RD
E
V
N
ELAE
E
L
G
A
D
VVVIGS
-
R
N
P
S
IST
H
LLGSNA
SS
VIRHA
N
L
P
VLVVR
fig|585034.4.peg.586
Escherichia coli IAI1
M
YK
TI
IM
PVD
V
FEM
E
-----
LSDK
A
V
R
H
-
A
E
FL
AQ
-
DD
G
VI
HLL
H
V
L
P
G-
-
-S
ASL
S
L
HR
F
A
A
D
V
RRF
E
E
H
LQ
H
EA
EER
LQ
T
M
VS
H
F
T
I
DP
SR
IKQ
HV
R
F
GS
V
RD
E
V
N
ELAE
E
L
G
A
D
VVVIGS
-
R
N
P
S
IST
H
LLGSNA
SS
VIRHA
N
L
P
VLVVR
fig|585034.5.peg.585
Escherichia coli IAI1
M
YK
TI
IM
PVD
V
FEM
E
-----
LSDK
A
V
R
H
-
A
E
FL
AQ
-
DD
G
VI
HLL
H
V
L
P
G-
-
-S
ASL
S
L
HR
F
A
A
D
V
RRF
E
E
H
LQ
H
EA
EER
LQ
T
M
VS
H
F
T
I
DP
SR
IKQ
HV
R
F
GS
V
RD
E
V
N
ELAE
E
L
G
A
D
VVVIGS
-
R
N
P
S
IST
H
LLGSNA
SS
VIRHA
N
L
P
VLVVR
fig|595495.4.peg.2005
Escherichia coli KO11
M
YK
TI
IM
PVD
V
FEM
E
-----
LSDK
A
V
R
H
-
A
E
FL
AQ
-
DD
G
VI
HLL
H
V
L
P
G-
-
-S
ASL
S
L
HR
F
A
A
D
V
RRF
E
E
H
LQ
H
EA
EER
LQ
T
M
VS
H
F
T
I
DP
SR
IKQ
HV
R
F
GS
V
RD
E
V
N
ELAE
E
L
G
A
D
VVVIGS
-
R
N
P
S
IST
H
LLGSNA
SS
VIRHA
N
L
P
VLVVR
fig|656419.3.peg.886
Escherichia coli M718
M
YK
TI
IM
PVD
V
FEM
E
-----
LSDK
A
V
R
H
-
A
E
FL
AQ
-
DD
G
VI
HLL
H
V
L
P
G-
-
-S
ASL
S
L
HR
F
A
A
D
V
RRF
E
E
H
LQ
H
EA
EER
LQ
T
M
VS
H
F
T
I
DP
SR
IKQ
HV
R
F
GS
V
RD
E
V
N
ELAE
E
L
G
A
D
VVVIGS
-
R
N
P
S
IST
H
LLGSNA
SS
VIRHA
N
L
P
VLVVR
fig|679207.4.peg.2851
Escherichia coli MS 107-1
M
YK
TI
IM
PVD
V
FEM
E
-----
LSDK
A
V
R
H
-
A
E
FL
AQ
-
DD
G
VI
HLL
H
V
L
P
G-
-
-S
ASL
S
L
HR
F
A
A
D
V
RRF
E
E
H
LQ
H
EA
EER
LQ
T
M
VS
H
F
T
I
DP
SR
IKQ
HV
R
F
GS
V
RD
E
V
N
ELAE
E
L
G
A
D
VVVIGS
-
R
N
P
S
IST
H
LLGSNA
SS
VIRHA
N
L
P
VLVVR
fig|749537.3.peg.4052
Escherichia coli MS 115-1
M
YK
TI
IM
PVD
V
FEM
E
-----
LSDK
A
V
R
H
-
A
E
FL
AQ
-
DD
G
VI
HLL
H
V
L
P
G-
-
-S
ASL
S
L
HR
F
A
A
D
V
RRF
E
E
H
LQ
H
EA
EER
LQ
T
M
VS
H
F
T
I
DP
SR
IKQ
HV
R
F
GS
V
RD
E
V
N
ELAE
E
L
G
A
D
VVVIGS
-
R
N
P
S
IST
H
LLGSNA
SS
VIRHA
N
L
P
VLVVR
fig|679206.4.peg.2859
Escherichia coli MS 119-7
M
YK
TI
IM
PVD
V
FEM
E
-----
LSDK
A
V
R
H
-
A
E
FL
AQ
-
DD
G
VI
HLL
H
V
L
P
G-
-
-S
ASL
S
L
HR
F
A
A
D
V
RRF
E
E
H
LQ
H
EA
EER
LQ
T
M
VS
H
F
T
I
DP
SR
IKQ
HV
R
F
GS
V
RD
E
V
N
ELAE
E
L
G
A
D
VVVIGS
-
R
N
P
S
IST
H
LLGSNA
SS
VIRHA
N
L
P
VLVVR
fig|679205.4.peg.614
Escherichia coli MS 124-1
M
YK
TI
IM
PVD
V
FEM
E
-----
LSDK
A
V
R
H
-
A
E
FL
AQ
-
DD
G
VI
HLL
H
V
L
P
G-
-
-S
ASL
S
L
HR
F
A
A
D
V
RRF
E
E
H
LQ
H
EA
EER
LQ
T
M
VS
H
F
T
I
DP
SR
IKQ
HV
R
F
GS
V
RD
E
V
N
ELAE
E
L
G
A
D
VVVIGS
-
R
N
P
S
IST
H
LLGSNA
SS
VIRHA
N
L
P
VLVVR
fig|679204.3.peg.2657
Escherichia coli MS 145-7
M
YK
TI
IM
PVD
V
FEM
E
-----
LSDK
A
V
R
H
-
A
E
FL
AQ
-
DD
G
VI
HLL
H
V
L
P
G-
-
-S
ASL
S
L
HR
F
A
A
D
V
RRF
E
E
H
LQ
H
EA
EER
LQ
T
M
VS
H
F
T
I
DP
SR
IKQ
HV
R
F
GS
V
RD
E
V
N
ELAE
E
L
G
A
D
VVVIGS
-
R
N
P
S
IST
H
LLGSNA
SS
VIRHA
N
L
P
VLVVR
fig|749545.3.peg.4893
Escherichia coli MS 182-1
M
YK
TI
IM
PVD
V
FEM
E
-----
LSDK
A
V
R
H
-
A
E
FL
AQ
-
DD
G
VI
HLL
H
V
L
P
G-
-
-S
ASL
S
L
HR
F
A
A
D
V
RRF
E
E
H
LQ
H
EA
EER
LQ
T
M
VS
H
F
T
I
DP
SR
IKQ
HV
R
F
GS
V
RD
E
V
N
ELAE
E
L
G
A
D
VVVIGS
-
R
N
P
S
IST
H
LLGSNA
SS
VIRHA
N
L
P
VLVVR
fig|749549.3.peg.4874
Escherichia coli MS 198-1
M
YK
TI
IM
PVD
V
FEM
E
-----
LSDK
A
V
R
H
-
A
E
FL
AQ
-
DD
G
VI
HLL
H
V
L
P
G-
-
-S
ASL
S
L
HR
F
A
A
D
V
RRF
E
E
H
LQ
H
EA
EER
LQ
T
M
VS
H
F
T
I
DP
SR
IKQ
HV
R
F
GS
V
RD
E
V
N
ELAE
E
L
G
A
D
VVVIGS
-
R
N
P
S
IST
H
LLGSNA
SS
VIRHA
N
L
P
VLVVR
fig|749531.3.peg.4094
Escherichia coli MS 69-1
M
YK
TI
IM
PVD
V
FEM
E
-----
LSDK
A
V
R
H
-
A
E
FL
AQ
-
DD
G
VI
HLL
H
V
L
P
G-
-
-S
ASL
S
L
HR
F
A
A
D
V
RRF
E
E
H
LQ
H
EA
EER
LQ
T
M
VS
H
F
T
I
DP
SR
IKQ
HV
R
F
GS
V
RD
E
V
N
ELAE
E
L
G
A
D
VVVIGS
-
R
N
P
S
IST
H
LLGSNA
SS
VIRHA
N
L
P
VLVVR
fig|749532.3.peg.3682
Escherichia coli MS 78-1
M
YK
TI
IM
PVD
V
FEM
E
-----
LSDK
A
V
R
H
-
A
E
FL
AQ
-
DD
G
VI
HLL
H
V
L
P
G-
-
-S
ASL
S
L
HR
F
A
A
D
V
RRF
E
E
H
LQ
H
EA
EER
LQ
T
M
VS
H
F
T
I
DP
SR
IKQ
HV
R
F
GS
V
RD
E
V
N
ELAE
E
L
G
A
D
VVVIGS
-
R
N
P
S
IST
H
LLGSNA
SS
VIRHA
N
L
P
VLVVR
fig|749533.3.peg.5418
Escherichia coli MS 84-1
M
YK
TI
IM
PVD
V
FEM
E
-----
LSDK
A
V
R
H
-
A
E
FL
AQ
-
DD
G
VI
HLL
H
V
L
P
G-
-
-S
ASL
S
L
HR
F
A
A
D
V
RRF
E
E
H
LQ
H
EA
EER
LQ
T
M
VS
H
F
T
I
DP
SR
IKQ
HV
R
F
GS
V
RD
E
V
N
ELAE
E
L
G
A
D
VVVIGS
-
R
N
P
S
IST
H
LLGSNA
SS
VIRHA
N
L
P
VLVVR
fig|585395.4.peg.645
Escherichia coli O103:H2 str. 12009
M
YK
TI
IM
PVD
V
FEM
E
-----
LSDK
A
V
R
H
-
A
E
FL
AQ
-
DD
G
VI
HLL
H
V
L
P
G-
-
-S
ASL
S
L
HR
F
A
A
D
V
RRF
E
E
H
LQ
H
EA
EER
LQ
T
M
VS
H
F
T
I
DP
SR
IKQ
HV
R
F
GS
V
RD
E
V
N
ELAE
E
L
G
A
D
VVVIGS
-
R
N
P
S
IST
H
LLGSNA
SS
VIRHA
N
L
P
VLVVR
fig|585396.4.peg.663
Escherichia coli O111:H- str. 11128
M
YK
TI
IM
PVD
V
FEM
E
-----
LSDK
A
V
R
H
-
A
E
FL
AQ
-
DD
G
VI
HLL
H
V
L
P
G-
-
-S
ASL
S
L
HR
F
A
A
D
V
RRF
E
E
H
LQ
H
EA
EER
LQ
T
M
VS
H
F
T
I
DP
SR
IKQ
HV
R
F
GS
V
RD
E
V
N
ELAE
E
L
G
A
D
VVVIGS
-
R
N
P
S
IST
H
LLGSNA
SS
VIRHA
N
L
P
VLVVR
fig|83334.1.peg.721
Escherichia coli O157:H7
M
YK
TI
IM
PVD
V
FEM
E
-----
LSDK
A
V
R
H
-
A
E
FL
AQ
-
DD
G
VI
HLL
H
V
L
P
G-
-
-S
ASL
S
L
HR
F
A
A
D
V
RRF
E
E
H
LQ
H
EA
EER
LQ
T
M
VS
H
F
T
I
DP
SR
IKQ
HV
R
F
GS
V
RD
E
V
N
ELAE
E
L
G
A
D
VVVIGS
-
R
N
P
S
IST
H
LLGSNA
SS
VIRHA
N
L
P
VLVVR
fig|155864.1.peg.642
Escherichia coli O157:H7 EDL933
M
YK
TI
IM
PVD
V
FEM
E
-----
LSDK
A
V
R
H
-
A
E
FL
AQ
-
DD
G
VI
HLL
H
V
L
P
G-
-
-S
ASL
S
L
HR
F
A
A
D
V
RRF
E
E
H
LQ
H
EA
EER
LQ
T
M
VS
H
F
T
I
DP
SR
IKQ
HV
R
F
GS
V
RD
E
V
N
ELAE
E
L
G
A
D
VVVIGS
-
R
N
P
S
IST
H
LLGSNA
SS
VIRHA
N
L
P
VLVVR
fig|444449.5.peg.5470
Escherichia coli O157:H7 str. EC4042
M
YK
TI
IM
PVD
V
FEM
E
-----
LSDK
A
V
R
H
-
A
E
FL
AQ
-
DD
G
VI
HLL
H
V
L
P
G-
-
-S
ASL
S
L
HR
F
A
A
D
V
RRF
E
E
H
LQ
H
EA
EER
LQ
T
M
VS
H
F
T
I
DP
SR
IKQ
HV
R
F
GS
V
RD
E
V
N
ELAE
E
L
G
A
D
VVVIGS
-
R
N
P
S
IST
H
LLGSNA
SS
VIRHA
N
L
P
VLVVR
fig|444451.5.peg.2306
Escherichia coli O157:H7 str. EC4196
M
YK
TI
IM
PVD
V
FEM
E
-----
LSDK
A
V
R
H
-
A
E
FL
AQ
-
DD
G
VI
HLL
H
V
L
P
G-
-
-S
ASL
S
L
HR
F
A
A
D
V
RRF
E
E
H
LQ
H
EA
EER
LQ
T
M
VS
H
F
T
I
DP
SR
IKQ
HV
R
F
GS
V
RD
E
V
N
ELAE
E
L
G
A
D
VVVIGS
-
R
N
P
S
IST
H
LLGSNA
SS
VIRHA
N
L
P
VLVVR
fig|444447.5.peg.3519
Escherichia coli O157:H7 str. EC4206
M
YK
TI
IM
PVD
V
FEM
E
-----
LSDK
A
V
R
H
-
A
E
FL
AQ
-
DD
G
VI
HLL
H
V
L
P
G-
-
-S
ASL
S
L
HR
F
A
A
D
V
RRF
E
E
H
LQ
H
EA
EER
LQ
T
M
VS
H
F
T
I
DP
SR
IKQ
HV
R
F
GS
V
RD
E
V
N
ELAE
E
L
G
A
D
VVVIGS
-
R
N
P
S
IST
H
LLGSNA
SS
VIRHA
N
L
P
VLVVR
fig|478005.5.peg.4024
Escherichia coli O157:H7 str. EC4486
M
YK
TI
IM
PVD
V
FEM
E
-----
LSDK
A
V
R
H
-
A
E
FL
AQ
-
DD
G
VI
HLL
H
V
L
P
G-
-
-S
ASL
S
L
HR
F
A
A
D
V
RRF
E
E
H
LQ
H
EA
EER
LQ
T
M
VS
H
F
T
I
DP
SR
IKQ
HV
R
F
GS
V
RD
E
V
N
ELAE
E
L
G
A
D
VVVIGS
-
R
N
P
S
IST
H
LLGSNA
SS
VIRHA
N
L
P
VLVVR
fig|637388.3.peg.1141
Escherichia coli O157:H7 str. FRIK2000
M
YK
TI
IM
PVD
V
FEM
E
-----
LSDK
A
V
R
H
-
A
E
FL
AQ
-
DD
G
VI
HLL
H
V
L
P
G-
-
-S
ASL
S
L
HR
F
A
A
D
V
RRF
E
E
H
LQ
H
EA
EER
LQ
T
M
VS
H
F
T
I
DP
SR
IKQ
HV
R
F
GS
V
RD
E
V
N
ELAE
E
L
G
A
D
VVVIGS
-
R
N
P
S
IST
H
LLGSNA
SS
VIRHA
N
L
P
VLVVR
fig|570506.3.peg.3678
Escherichia coli O157:H7 str. FRIK966
M
YK
TI
IM
PVD
V
FEM
E
-----
LSDK
A
V
R
H
-
A
E
FL
AQ
-
DD
G
VI
HLL
H
V
L
P
G-
-
-S
ASL
S
L
HR
F
A
A
D
V
RRF
E
E
H
LQ
H
EA
EER
LQ
T
M
VS
H
F
T
I
DP
SR
IKQ
HV
R
F
GS
V
RD
E
V
N
ELAE
E
L
G
A
D
VVVIGS
-
R
N
P
S
IST
H
LLGSNA
SS
VIRHA
N
L
P
VLVVR
fig|573235.3.peg.690
Escherichia coli O26:H11 str. 11368
M
YK
TI
IM
PVD
V
FEM
E
-----
LSDK
A
V
R
H
-
A
E
FL
AQ
-
DD
G
VI
HLL
H
V
L
P
G-
-
-S
ASL
S
L
HR
F
A
A
D
V
RRF
E
E
H
LQ
H
EA
EER
LQ
T
M
VS
H
F
T
I
DP
SR
IKQ
HV
R
F
GS
V
RD
E
V
N
ELAE
E
L
G
A
D
VVVIGS
-
R
N
P
S
IST
H
LLGSNA
SS
VIRHA
N
L
P
VLVVR
fig|701177.3.peg.769
Escherichia coli O55:H7 str. CB9615
M
YK
TI
IM
PVD
V
FEM
E
-----
LSDK
A
V
R
H
-
A
E
FL
AQ
-
DD
G
VI
HLL
H
V
L
P
G-
-
-S
ASL
S
L
HR
F
A
A
D
V
RRF
E
E
H
LQ
H
EA
EER
LQ
T
M
VS
H
F
T
I
DP
SR
IKQ
HV
R
F
GS
V
RD
E
V
N
ELAE
E
L
G
A
D
VVVIGS
-
R
N
P
S
IST
H
LLGSNA
SS
VIRHA
N
L
P
VLVVR
fig|409438.11.peg.799
Escherichia coli SE11
M
YK
TI
IM
PVD
V
FEM
E
-----
LSDK
A
V
R
H
-
A
E
FL
AQ
-
DD
G
VI
HLL
H
V
L
P
G-
-
-S
ASL
S
L
HR
F
A
A
D
V
RRF
E
E
H
LQ
H
EA
EER
LQ
T
M
VS
H
F
T
I
DP
SR
IKQ
HV
R
F
GS
V
RD
E
V
N
ELAE
E
L
G
A
D
VVVIGS
-
R
N
P
S
IST
H
LLGSNA
SS
VIRHA
N
L
P
VLVVR
fig|656443.3.peg.865
Escherichia coli TA271
M
YK
TI
IM
PVD
V
FEM
E
-----
LSDK
A
V
R
H
-
A
E
FL
AQ
-
DD
G
VI
HLL
H
V
L
P
G-
-
-S
ASL
S
L
HR
F
A
A
D
V
RRF
E
E
H
LQ
H
EA
EER
LQ
T
M
VS
H
F
T
I
DP
SR
IKQ
HV
R
F
GS
V
RD
E
V
N
ELAE
E
L
G
A
D
VVVIGS
-
R
N
P
S
IST
H
LLGSNA
SS
VIRHA
N
L
P
VLVVR
fig|585056.7.peg.900
Escherichia coli UMN026
M
YK
TI
IM
PVD
V
FEM
E
-----
LSDK
A
V
R
H
-
A
E
FL
AQ
-
DD
G
VI
HLL
H
V
L
P
G-
-
-S
ASL
S
L
HR
F
A
A
D
V
RRF
E
E
H
LQ
H
EA
EER
LQ
T
M
VS
H
F
T
I
DP
SR
IKQ
HV
R
F
GS
V
RD
E
V
N
ELAE
E
L
G
A
D
VVVIGS
-
R
N
P
S
IST
H
LLGSNA
SS
VIRHA
N
L
P
VLVVR
fig|566546.3.peg.2840
Escherichia coli W
M
YK
TI
IM
PVD
V
FEM
E
-----
LSDK
A
V
R
H
-
A
E
FL
AQ
-
DD
G
VI
HLL
H
V
L
P
G-
-
-S
ASL
S
L
HR
F
A
A
D
V
RRF
E
E
H
LQ
H
EA
EER
LQ
T
M
VS
H
F
T
I
DP
SR
IKQ
HV
R
F
GS
V
RD
E
V
N
ELAE
E
L
G
A
D
VVVIGS
-
R
N
P
S
IST
H
LLGSNA
SS
VIRHA
N
L
P
VLVVR
fig|566546.4.peg.667
Escherichia coli W
M
YK
TI
IM
PVD
V
FEM
E
-----
LSDK
A
V
R
H
-
A
E
FL
AQ
-
DD
G
VI
HLL
H
V
L
P
G-
-
-S
ASL
S
L
HR
F
A
A
D
V
RRF
E
E
H
LQ
H
EA
EER
LQ
T
M
VS
H
F
T
I
DP
SR
IKQ
HV
R
F
GS
V
RD
E
V
N
ELAE
E
L
G
A
D
VVVIGS
-
R
N
P
S
IST
H
LLGSNA
SS
VIRHA
N
L
P
VLVVR
fig|344610.7.peg.1082
Escherichia coli 53638 (2-129/129)
E
-----
LSDK
A
V
R
H
-
A
E
FL
AQ
-
DD
G
VI
HLL
H
V
L
P
G-
-
-S
ASL
S
L
HR
F
A
A
D
V
RRF
E
E
H
LQ
H
EA
QER
LQ
T
M
VS
H
F
T
I
DP
SR
IKQ
HV
R
F
GS
V
RD
E
V
N
ELAE
E
L
G
A
D
VVVIGS
-
R
N
P
S
IST
H
LLGSNA
SS
VIRHA
N
L
P
VLVVR
fig|749548.3.peg.4421
Escherichia coli MS 196-1 (2-129/129)
E
-----
LSDK
A
V
R
H
-
A
E
FL
AQ
-
DD
G
VI
HLL
H
V
L
P
G-
-
-S
ASL
S
L
HR
F
A
A
D
V
RRF
E
E
H
LQ
H
EA
QER
LQ
T
M
VS
H
F
T
I
DP
SR
IKQ
HV
R
F
GS
V
RD
E
V
N
ELAE
E
L
G
A
D
VVVIGS
-
R
N
P
S
IST
H
LLGSNA
SS
VIRHA
N
L
P
VLVVR
fig|562.373.peg.3128
Escherichia coli 1125A (2-129/129)
E
-----
LSDK
A
V
R
H
-
A
E
FL
AQ
-
DD
G
VI
HLL
H
V
L
P
G-
-
-S
ASL
S
L
HR
F
A
A
D
V
RRF
E
E
H
LQ
H
EA
EER
LQ
T
M
VS
H
F
T
I
DP
SR
IKQ
HV
R
F
GS
V
RD
E
V
N
ELAE
E
L
G
A
D
VVVIGS
-
R
N
P
S
IST
H
LLGSNA
SS
VIRHA
N
L
P
VLVVR
fig|562.374.peg.5382
Escherichia coli 536A (2-129/129)
E
-----
LSDK
A
V
R
H
-
A
E
FL
AQ
-
DD
G
VI
HLL
H
V
L
P
G-
-
-S
ASL
S
L
HR
F
A
A
D
V
RRF
E
E
H
LQ
H
EA
EER
LQ
T
M
VS
H
F
T
I
DP
SR
IKQ
HV
R
F
GS
V
RD
E
V
N
ELAE
E
L
G
A
D
VVVIGS
-
R
N
P
S
IST
H
LLGSNA
SS
VIRHA
N
L
P
VLVVR
fig|155864.8.peg.659
Escherichia coli O157:H7 EDL933 (2-129/129)
E
-----
LSDK
A
V
R
H
-
A
E
FL
AQ
-
DD
G
VI
HLL
H
V
L
P
G-
-
-S
ASL
S
L
HR
F
A
A
D
V
RRF
E
E
H
LQ
H
EA
EER
LQ
T
M
VS
H
F
T
I
DP
SR
IKQ
HV
R
F
GS
V
RD
E
V
N
ELAE
E
L
G
A
D
VVVIGS
-
R
N
P
S
IST
H
LLGSNA
SS
VIRHA
N
L
P
VLVVR
fig|444454.5.peg.5134
Escherichia coli O157:H7 str. EC4024 (2-129/129)
E
-----
LSDK
A
V
R
H
-
A
E
FL
AQ
-
DD
G
VI
HLL
H
V
L
P
G-
-
-S
ASL
S
L
HR
F
A
A
D
V
RRF
E
E
H
LQ
H
EA
EER
LQ
T
M
VS
H
F
T
I
DP
SR
IKQ
HV
R
F
GS
V
RD
E
V
N
ELAE
E
L
G
A
D
VVVIGS
-
R
N
P
S
IST
H
LLGSNA
SS
VIRHA
N
L
P
VLVVR
fig|444448.5.peg.3344
Escherichia coli O157:H7 str. EC4045 (2-129/129)
E
-----
LSDK
A
V
R
H
-
A
E
FL
AQ
-
DD
G
VI
HLL
H
V
L
P
G-
-
-S
ASL
S
L
HR
F
A
A
D
V
RRF
E
E
H
LQ
H
EA
EER
LQ
T
M
VS
H
F
T
I
DP
SR
IKQ
HV
R
F
GS
V
RD
E
V
N
ELAE
E
L
G
A
D
VVVIGS
-
R
N
P
S
IST
H
LLGSNA
SS
VIRHA
N
L
P
VLVVR
fig|444453.5.peg.686
Escherichia coli O157:H7 str. EC4076 (2-129/129)
E
-----
LSDK
A
V
R
H
-
A
E
FL
AQ
-
DD
G
VI
HLL
H
V
L
P
G-
-
-S
ASL
S
L
HR
F
A
A
D
V
RRF
E
E
H
LQ
H
EA
EER
LQ
T
M
VS
H
F
T
I
DP
SR
IKQ
HV
R
F
GS
V
RD
E
V
N
ELAE
E
L
G
A
D
VVVIGS
-
R
N
P
S
IST
H
LLGSNA
SS
VIRHA
N
L
P
VLVVR
fig|444452.5.peg.841
Escherichia coli O157:H7 str. EC4113 (2-129/129)
E
-----
LSDK
A
V
R
H
-
A
E
FL
AQ
-
DD
G
VI
HLL
H
V
L
P
G-
-
-S
ASL
S
L
HR
F
A
A
D
V
RRF
E
E
H
LQ
H
EA
EER
LQ
T
M
VS
H
F
T
I
DP
SR
IKQ
HV
R
F
GS
V
RD
E
V
N
ELAE
E
L
G
A
D
VVVIGS
-
R
N
P
S
IST
H
LLGSNA
SS
VIRHA
N
L
P
VLVVR
fig|444450.8.peg.804
Escherichia coli O157:H7 str. EC4115 (2-129/129)
E
-----
LSDK
A
V
R
H
-
A
E
FL
AQ
-
DD
G
VI
HLL
H
V
L
P
G-
-
-S
ASL
S
L
HR
F
A
A
D
V
RRF
E
E
H
LQ
H
EA
EER
LQ
T
M
VS
H
F
T
I
DP
SR
IKQ
HV
R
F
GS
V
RD
E
V
N
ELAE
E
L
G
A
D
VVVIGS
-
R
N
P
S
IST
H
LLGSNA
SS
VIRHA
N
L
P
VLVVR
fig|478004.5.peg.1512
Escherichia coli O157:H7 str. EC4401 (2-129/129)
E
-----
LSDK
A
V
R
H
-
A
E
FL
AQ
-
DD
G
VI
HLL
H
V
L
P
G-
-
-S
ASL
S
L
HR
F
A
A
D
V
RRF
E
E
H
LQ
H
EA
EER
LQ
T
M
VS
H
F
T
I
DP
SR
IKQ
HV
R
F
GS
V
RD
E
V
N
ELAE
E
L
G
A
D
VVVIGS
-
R
N
P
S
IST
H
LLGSNA
SS
VIRHA
N
L
P
VLVVR
fig|478006.5.peg.799
Escherichia coli O157:H7 str. EC4501 (2-129/129)
E
-----
LSDK
A
V
R
H
-
A
E
FL
AQ
-
DD
G
VI
HLL
H
V
L
P
G-
-
-S
ASL
S
L
HR
F
A
A
D
V
RRF
E
E
H
LQ
H
EA
EER
LQ
T
M
VS
H
F
T
I
DP
SR
IKQ
HV
R
F
GS
V
RD
E
V
N
ELAE
E
L
G
A
D
VVVIGS
-
R
N
P
S
IST
H
LLGSNA
SS
VIRHA
N
L
P
VLVVR
fig|478007.5.peg.1003
Escherichia coli O157:H7 str. EC508 (2-129/129)
E
-----
LSDK
A
V
R
H
-
A
E
FL
AQ
-
DD
G
VI
HLL
H
V
L
P
G-
-
-S
ASL
S
L
HR
F
A
A
D
V
RRF
E
E
H
LQ
H
EA
EER
LQ
T
M
VS
H
F
T
I
DP
SR
IKQ
HV
R
F
GS
V
RD
E
V
N
ELAE
E
L
G
A
D
VVVIGS
-
R
N
P
S
IST
H
LLGSNA
SS
VIRHA
N
L
P
VLVVR
fig|478008.5.peg.1746
Escherichia coli O157:H7 str. EC869 (2-129/129)
E
-----
LSDK
A
V
R
H
-
A
E
FL
AQ
-
DD
G
VI
HLL
H
V
L
P
G-
-
-S
ASL
S
L
HR
F
A
A
D
V
RRF
E
E
H
LQ
H
EA
EER
LQ
T
M
VS
H
F
T
I
DP
SR
IKQ
HV
R
F
GS
V
RD
E
V
N
ELAE
E
L
G
A
D
VVVIGS
-
R
N
P
S
IST
H
LLGSNA
SS
VIRHA
N
L
P
VLVVR
fig|386585.9.peg.757
Escherichia coli O157:H7 str. Sakai (2-129/129)
E
-----
LSDK
A
V
R
H
-
A
E
FL
AQ
-
DD
G
VI
HLL
H
V
L
P
G-
-
-S
ASL
S
L
HR
F
A
A
D
V
RRF
E
E
H
LQ
H
EA
EER
LQ
T
M
VS
H
F
T
I
DP
SR
IKQ
HV
R
F
GS
V
RD
E
V
N
ELAE
E
L
G
A
D
VVVIGS
-
R
N
P
S
IST
H
LLGSNA
SS
VIRHA
N
L
P
VLVVR
fig|544404.4.peg.669
Escherichia coli O157:H7 str. TW14359 (2-129/129)
E
-----
LSDK
A
V
R
H
-
A
E
FL
AQ
-
DD
G
VI
HLL
H
V
L
P
G-
-
-S
ASL
S
L
HR
F
A
A
D
V
RRF
E
E
H
LQ
H
EA
EER
LQ
T
M
VS
H
F
T
I
DP
SR
IKQ
HV
R
F
GS
V
RD
E
V
N
ELAE
E
L
G
A
D
VVVIGS
-
R
N
P
S
IST
H
LLGSNA
SS
VIRHA
N
L
P
VLVVR
fig|502346.5.peg.552
Escherichia coli O157:H7 str. TW14588 (2-129/129)
E
-----
LSDK
A
V
R
H
-
A
E
FL
AQ
-
DD
G
VI
HLL
H
V
L
P
G-
-
-S
ASL
S
L
HR
F
A
A
D
V
RRF
E
E
H
LQ
H
EA
EER
LQ
T
M
VS
H
F
T
I
DP
SR
IKQ
HV
R
F
GS
V
RD
E
V
N
ELAE
E
L
G
A
D
VVVIGS
-
R
N
P
S
IST
H
LLGSNA
SS
VIRHA
N
L
P
VLVVR
fig|1040638.4.peg.4099
Escherichia coli O104:H4 str. LB226692 (68-211/227)
LV
A
V
N
L
ASE
E
PYHNA
L
NE
K
L
V
K
ET
I
E
LA
E
Q
V
NH
T
EVHL
V
G
A
Y
P
VT
P
IN
IAI
E
L
PE
F
D
P
S
V
--Y
ND
A
I
R
G
QH
LLA
M
K
A
L
RQ
KF
G
I
NE
N
-
-MT
HVE
K
G
L
P
E
E
V
I
P
D
LAE
H
L
Q
A
G
I
VV
L
G
TV
G
R
T
G
IS
A
A
F
LG
NT
A
EQ
VI
D
H
L
R
C
D
L
LV
IK
fig|6666666.5357.peg.1422
Escherichia coli TY-2482 (157-300/316)
LV
A
V
N
L
ASE
E
PYHNA
L
NE
K
L
V
K
ET
I
E
LA
E
Q
V
NH
T
EVHL
V
G
A
Y
P
VT
P
IN
IAI
E
L
PE
F
D
P
S
V
--Y
ND
A
I
R
G
QH
LLA
M
K
A
L
RQ
KF
G
I
NE
N
-
-MT
HVE
K
G
L
P
E
E
V
I
P
D
LAE
H
L
Q
A
G
I
VV
L
G
TV
G
R
T
G
IS
A
A
F
LG
NT
A
EQ
VI
D
H
L
R
C
D
L
LV
IK
fig|216592.1.peg.1841
Escherichia coli 042 (166-309/325)
LV
A
V
N
L
ASE
E
PYHNA
L
NE
K
L
V
K
ET
I
E
LA
E
Q
V
NH
T
EVHL
V
G
A
Y
P
VT
P
IN
IAI
E
L
PE
F
D
P
S
V
--Y
ND
A
I
R
G
QH
LLA
M
K
A
L
RQ
KF
G
I
NE
N
-
-MT
HVE
K
G
L
P
E
E
V
I
P
D
LAE
H
L
Q
A
G
I
VV
L
G
TV
G
R
T
G
IS
A
A
F
LG
NT
A
EQ
VI
D
H
L
R
C
D
L
LV
IK
fig|216592.3.peg.1503
Escherichia coli 042 (157-300/316)
LV
A
V
N
L
ASE
E
PYHNA
L
NE
K
L
V
K
ET
I
E
LA
E
Q
V
NH
T
EVHL
V
G
A
Y
P
VT
P
IN
IAI
E
L
PE
F
D
P
S
V
--Y
ND
A
I
R
G
QH
LLA
M
K
A
L
RQ
KF
G
I
NE
N
-
-MT
HVE
K
G
L
P
E
E
V
I
P
D
LAE
H
L
Q
A
G
I
VV
L
G
TV
G
R
T
G
IS
A
A
F
LG
NT
A
EQ
VI
D
H
L
R
C
D
L
LV
IK
fig|358709.5.peg.1672
Escherichia coli 101-1 (157-300/316)
LV
A
V
N
L
ASE
E
PYHNA
L
NE
K
L
V
K
ET
I
E
LA
E
Q
V
NH
T
EVHL
V
G
A
Y
P
VT
P
IN
IAI
E
L
PE
F
D
P
S
V
--Y
ND
A
I
R
G
QH
LLA
M
K
A
L
RQ
KF
G
I
NE
N
-
-MT
HVE
K
G
L
P
E
E
V
I
P
D
LAE
H
L
Q
A
G
I
VV
L
G
TV
G
R
T
G
IS
A
A
F
LG
NT
A
EQ
VI
D
H
L
R
C
D
L
LV
IK
fig|562.371.peg.1359
Escherichia coli 1044A (157-300/316)
LV
A
V
N
L
ASE
E
PYHNA
L
NE
K
L
V
K
ET
I
E
LA
E
Q
V
NH
T
EVHL
V
G
A
Y
P
VT
P
IN
IAI
E
L
PE
F
D
P
S
V
--Y
ND
A
I
R
G
QH
LLA
M
K
A
L
RQ
KF
G
I
NE
N
-
-MT
HVE
K
G
L
P
E
E
V
I
P
D
LAE
H
L
Q
A
G
I
VV
L
G
TV
G
R
T
G
IS
A
A
F
LG
NT
A
EQ
VI
D
H
L
R
C
D
L
LV
IK
fig|562.373.peg.5185
Escherichia coli 1125A (157-300/316)
LV
A
V
N
L
ASE
E
PYHNA
L
NE
K
L
V
K
ET
I
E
LA
E
Q
V
NH
T
EVHL
V
G
A
Y
P
VT
P
IN
IAI
E
L
PE
F
D
P
S
V
--Y
ND
A
I
R
G
QH
LLA
M
K
A
L
RQ
KF
G
I
NE
N
-
-MT
HVE
K
G
L
P
E
E
V
I
P
D
LAE
H
L
Q
A
G
I
VV
L
G
TV
G
R
T
G
IS
A
A
F
LG
NT
A
EQ
VI
D
H
L
R
C
D
L
LV
IK
fig|562.372.peg.814
Escherichia coli 1212A (157-300/316)
LV
A
V
N
L
ASE
E
PYHNA
L
NE
K
L
V
K
ET
I
E
LA
E
Q
V
NH
T
EVHL
V
G
A
Y
P
VT
P
IN
IAI
E
L
PE
F
D
P
S
V
--Y
ND
A
I
R
G
QH
LLA
M
K
A
L
RQ
KF
G
I
NE
N
-
-MT
HVE
K
G
L
P
E
E
V
I
P
D
LAE
H
L
Q
A
G
I
VV
L
G
TV
G
R
T
G
IS
A
A
F
LG
NT
A
EQ
VI
D
H
L
R
C
D
L
LV
IK
fig|670888.3.peg.2029
Escherichia coli 1827-70 (157-300/316)
LV
A
V
N
L
ASE
E
PYHNA
L
NE
K
L
V
K
ET
I
E
LA
E
Q
V
NH
T
EVHL
V
G
A
Y
P
VT
P
IN
IAI
E
L
PE
F
D
P
S
V
--Y
ND
A
I
R
G
QH
LLA
M
K
A
L
RQ
KF
G
I
NE
N
-
-MT
HVE
K
G
L
P
E
E
V
I
P
D
LAE
H
L
Q
A
G
I
VV
L
G
TV
G
R
T
G
IS
A
A
F
LG
NT
A
EQ
VI
D
H
L
R
C
D
L
LV
IK
fig|670897.3.peg.2419
Escherichia coli 2362-75 (157-300/316)
LV
A
V
N
L
ASE
E
PYHNA
L
NE
K
L
V
K
ET
I
E
LA
E
Q
V
NH
T
EVHL
V
G
A
Y
P
VT
P
IN
IAI
E
L
PE
F
D
P
S
V
--Y
ND
A
I
R
G
QH
LLA
M
K
A
L
RQ
KF
G
I
NE
N
-
-MT
HVE
K
G
L
P
E
E
V
I
P
D
LAE
H
L
Q
A
G
I
VV
L
G
TV
G
R
T
G
IS
A
A
F
LG
NT
A
EQ
VI
D
H
L
R
C
D
L
LV
IK
fig|362663.8.peg.1397
Escherichia coli 536 (157-300/316)
LV
A
V
N
L
ASE
E
PYHNA
L
NE
K
L
V
K
ET
I
E
LA
E
Q
V
NH
T
EVHL
V
G
A
Y
P
VT
P
IN
IAI
E
L
PE
F
D
P
S
V
--Y
ND
A
I
R
G
QH
LLA
M
K
A
L
RQ
KF
G
I
NE
N
-
-MT
HVE
K
G
L
P
E
E
V
I
P
D
LAE
H
L
Q
A
G
I
VV
L
G
TV
G
R
T
G
IS
A
A
F
LG
NT
A
EQ
VI
D
H
L
R
C
D
L
LV
IK
fig|362663.9.peg.1399
Escherichia coli 536 (157-300/316)
LV
A
V
N
L
ASE
E
PYHNA
L
NE
K
L
V
K
ET
I
E
LA
E
Q
V
NH
T
EVHL
V
G
A
Y
P
VT
P
IN
IAI
E
L
PE
F
D
P
S
V
--Y
ND
A
I
R
G
QH
LLA
M
K
A
L
RQ
KF
G
I
NE
N
-
-MT
HVE
K
G
L
P
E
E
V
I
P
D
LAE
H
L
Q
A
G
I
VV
L
G
TV
G
R
T
G
IS
A
A
F
LG
NT
A
EQ
VI
D
H
L
R
C
D
L
LV
IK
fig|344610.3.peg.1139
Escherichia coli 53638 (157-300/316)
LV
A
V
N
L
ASE
E
PYHNA
L
NE
K
L
V
K
ET
I
E
LA
E
Q
V
NH
T
EVHL
V
G
A
Y
P
VT
P
IN
IAI
E
L
PE
F
D
P
S
V
--Y
ND
A
I
R
G
QH
LLA
M
K
A
L
RQ
KF
G
I
NE
N
-
-MT
HVE
K
G
L
P
E
E
V
I
P
D
LAE
H
L
Q
A
G
I
VV
L
G
TV
G
R
T
G
IS
A
A
F
LG
NT
A
EQ
VI
D
H
L
R
C
D
L
LV
IK
fig|344610.7.peg.5020
Escherichia coli 53638 (157-300/316)
LV
A
V
N
L
ASE
E
PYHNA
L
NE
K
L
V
K
ET
I
E
LA
E
Q
V
NH
T
EVHL
V
G
A
Y
P
VT
P
IN
IAI
E
L
PE
F
D
P
S
V
--Y
ND
A
I
R
G
QH
LLA
M
K
A
L
RQ
KF
G
I
NE
N
-
-MT
HVE
K
G
L
P
E
E
V
I
P
D
LAE
H
L
Q
A
G
I
VV
L
G
TV
G
R
T
G
IS
A
A
F
LG
NT
A
EQ
VI
D
H
L
R
C
D
L
LV
IK
fig|562.374.peg.6040
Escherichia coli 536A (157-300/316)
LV
A
V
N
L
ASE
E
PYHNA
L
NE
K
L
V
K
ET
I
E
LA
E
Q
V
NH
T
EVHL
V
G
A
Y
P
VT
P
IN
IAI
E
L
PE
F
D
P
S
V
--Y
ND
A
I
R
G
QH
LLA
M
K
A
L
RQ
KF
G
I
NE
N
-
-MT
HVE
K
G
L
P
E
E
V
I
P
D
LAE
H
L
Q
A
G
I
VV
L
G
TV
G
R
T
G
IS
A
A
F
LG
NT
A
EQ
VI
D
H
L
R
C
D
L
LV
IK
fig|585055.6.peg.1527
Escherichia coli 55989 (157-300/316)
LV
A
V
N
L
ASE
E
PYHNA
L
NE
K
L
V
K
ET
I
E
LA
E
Q
V
NH
T
EVHL
V
G
A
Y
P
VT
P
IN
IAI
E
L
PE
F
D
P
S
V
--Y
ND
A
I
R
G
QH
LLA
M
K
A
L
RQ
KF
G
I
NE
N
-
-MT
HVE
K
G
L
P
E
E
V
I
P
D
LAE
H
L
Q
A
G
I
VV
L
G
TV
G
R
T
G
IS
A
A
F
LG
NT
A
EQ
VI
D
H
L
R
C
D
L
LV
IK
fig|585055.8.peg.1528
Escherichia coli 55989 (157-300/316)
LV
A
V
N
L
ASE
E
PYHNA
L
NE
K
L
V
K
ET
I
E
LA
E
Q
V
NH
T
EVHL
V
G
A
Y
P
VT
P
IN
IAI
E
L
PE
F
D
P
S
V
--Y
ND
A
I
R
G
QH
LLA
M
K
A
L
RQ
KF
G
I
NE
N
-
-MT
HVE
K
G
L
P
E
E
V
I
P
D
LAE
H
L
Q
A
G
I
VV
L
G
TV
G
R
T
G
IS
A
A
F
LG
NT
A
EQ
VI
D
H
L
R
C
D
L
LV
IK
fig|525281.3.peg.87
Escherichia coli 83972 (157-300/316)
LV
A
V
N
L
ASE
E
PYHNA
L
NE
K
L
V
K
ET
I
E
LA
E
Q
V
NH
T
EVHL
V
G
A
Y
P
VT
P
IN
IAI
E
L
PE
F
D
P
S
V
--Y
ND
A
I
R
G
QH
LLA
M
K
A
L
RQ
KF
G
I
NE
N
-
-MT
HVE
K
G
L
P
E
E
V
I
P
D
LAE
H
L
Q
A
G
I
VV
L
G
TV
G
R
T
G
IS
A
A
F
LG
NT
A
EQ
VI
D
H
L
R
C
D
L
LV
IK
fig|655817.3.peg.1695
Escherichia coli ABU 83972 (157-300/316)
LV
A
V
N
L
ASE
E
PYHNA
L
NE
K
L
V
K
ET
I
E
LA
E
Q
V
NH
T
EVHL
V
G
A
Y
P
VT
P
IN
IAI
E
L
PE
F
D
P
S
V
--Y
ND
A
I
R
G
QH
LLA
M
K
A
L
RQ
KF
G
I
NE
N
-
-MT
HVE
K
G
L
P
E
E
V
I
P
D
LAE
H
L
Q
A
G
I
VV
L
G
TV
G
R
T
G
IS
A
A
F
LG
NT
A
EQ
VI
D
H
L
R
C
D
L
LV
IK
fig|405955.13.peg.1449
Escherichia coli APEC O1 (157-300/316)
LV
A
V
N
L
ASE
E
PYHNA
L
NE
K
L
V
K
ET
I
E
LA
E
Q
V
NH
T
EVHL
V
G
A
Y
P
VT
P
IN
IAI
E
L
PE
F
D
P
S
V
--Y
ND
A
I
R
G
QH
LLA
M
K
A
L
RQ
KF
G
I
NE
N
-
-MT
HVE
K
G
L
P
E
E
V
I
P
D
LAE
H
L
Q
A
G
I
VV
L
G
TV
G
R
T
G
IS
A
A
F
LG
NT
A
EQ
VI
D
H
L
R
C
D
L
LV
IK
fig|405955.9.peg.1196
Escherichia coli APEC O1 (166-309/325)
LV
A
V
N
L
ASE
E
PYHNA
L
NE
K
L
V
K
ET
I
E
LA
E
Q
V
NH
T
EVHL
V
G
A
Y
P
VT
P
IN
IAI
E
L
PE
F
D
P
S
V
--Y
ND
A
I
R
G
QH
LLA
M
K
A
L
RQ
KF
G
I
NE
N
-
-MT
HVE
K
G
L
P
E
E
V
I
P
D
LAE
H
L
Q
A
G
I
VV
L
G
TV
G
R
T
G
IS
A
A
F
LG
NT
A
EQ
VI
D
H
L
R
C
D
L
LV
IK
fig|481805.3.peg.2460
Escherichia coli ATCC 8739 (157-300/316)
LV
A
V
N
L
ASE
E
PYHNA
L
NE
K
L
V
K
ET
I
E
LA
E
Q
V
NH
T
EVHL
V
G
A
Y
P
VT
P
IN
IAI
E
L
PE
F
D
P
S
V
--Y
ND
A
I
R
G
QH
LLA
M
K
A
L
RQ
KF
G
I
NE
N
-
-MT
HVE
K
G
L
P
E
E
V
I
P
D
LAE
H
L
Q
A
G
I
VV
L
G
TV
G
R
T
G
IS
A
A
F
LG
NT
A
EQ
VI
D
H
L
R
C
D
L
LV
IK
fig|481805.6.peg.2449
Escherichia coli ATCC 8739 (157-300/316)
LV
A
V
N
L
ASE
E
PYHNA
L
NE
K
L
V
K
ET
I
E
LA
E
Q
V
NH
T
EVHL
V
G
A
Y
P
VT
P
IN
IAI
E
L
PE
F
D
P
S
V
--Y
ND
A
I
R
G
QH
LLA
M
K
A
L
RQ
KF
G
I
NE
N
-
-MT
HVE
K
G
L
P
E
E
V
I
P
D
LAE
H
L
Q
A
G
I
VV
L
G
TV
G
R
T
G
IS
A
A
F
LG
NT
A
EQ
VI
D
H
L
R
C
D
L
LV
IK
fig|413997.3.peg.1381
Escherichia coli B str. REL606 (157-300/316)
LV
A
V
N
L
ASE
E
PYHNA
L
NE
K
L
V
K
ET
I
E
LA
E
Q
V
NH
T
EVHL
V
G
A
Y
P
VT
P
IN
IAI
E
L
PE
F
D
P
S
V
--Y
ND
A
I
R
G
QH
LLA
M
K
A
L
RQ
KF
G
I
NE
N
-
-MT
HVE
K
G
L
P
E
E
V
I
P
D
LAE
H
L
Q
A
G
I
VV
L
G
TV
G
R
T
G
IS
A
A
F
LG
NT
A
EQ
VI
D
H
L
R
C
D
L
LV
IK
fig|550672.3.peg.820
Escherichia coli B088 (157-300/316)
LV
A
V
N
L
ASE
E
PYHNA
L
NE
K
L
V
K
ET
I
E
LA
E
Q
V
NH
T
EVHL
V
G
A
Y
P
VT
P
IN
IAI
E
L
PE
F
D
P
S
V
--Y
ND
A
I
R
G
QH
LLA
M
K
A
L
RQ
KF
G
I
NE
N
-
-MT
HVE
K
G
L
P
E
E
V
I
P
D
LAE
H
L
Q
A
G
I
VV
L
G
TV
G
R
T
G
IS
A
A
F
LG
NT
A
EQ
VI
D
H
L
R
C
D
L
LV
IK
fig|344601.3.peg.168
Escherichia coli B171 (157-300/316)
LV
A
V
N
L
ASE
E
PYHNA
L
NE
K
L
V
K
ET
I
E
LA
E
Q
V
NH
T
EVHL
V
G
A
Y
P
VT
P
IN
IAI
E
L
PE
F
D
P
S
V
--Y
ND
A
I
R
G
QH
LLA
M
K
A
L
RQ
KF
G
I
NE
N
-
-MT
HVE
K
G
L
P
E
E
V
I
P
D
LAE
H
L
Q
A
G
I
VV
L
G
TV
G
R
T
G
IS
A
A
F
LG
NT
A
EQ
VI
D
H
L
R
C
D
L
LV
IK
fig|344601.5.peg.164
Escherichia coli B171 (157-300/316)
LV
A
V
N
L
ASE
E
PYHNA
L
NE
K
L
V
K
ET
I
E
LA
E
Q
V
NH
T
EVHL
V
G
A
Y
P
VT
P
IN
IAI
E
L
PE
F
D
P
S
V
--Y
ND
A
I
R
G
QH
LLA
M
K
A
L
RQ
KF
G
I
NE
N
-
-MT
HVE
K
G
L
P
E
E
V
I
P
D
LAE
H
L
Q
A
G
I
VV
L
G
TV
G
R
T
G
IS
A
A
F
LG
NT
A
EQ
VI
D
H
L
R
C
D
L
LV
IK
fig|550676.3.peg.885
Escherichia coli B185 (157-300/316)
LV
A
V
N
L
ASE
E
PYHNA
L
NE
K
L
V
K
ET
I
E
LA
E
Q
V
NH
T
EVHL
V
G
A
Y
P
VT
P
IN
IAI
E
L
PE
F
D
P
S
V
--Y
ND
A
I
R
G
QH
LLA
M
K
A
L
RQ
KF
G
I
NE
N
-
-MT
HVE
K
G
L
P
E
E
V
I
P
D
LAE
H
L
Q
A
G
I
VV
L
G
TV
G
R
T
G
IS
A
A
F
LG
NT
A
EQ
VI
D
H
L
R
C
D
L
LV
IK
fig|550677.3.peg.2789
Escherichia coli B354 (157-300/316)
LV
A
V
N
L
ASE
E
PYHNA
L
NE
K
L
V
K
ET
I
E
LA
E
Q
V
NH
T
EVHL
V
G
A
Y
P
VT
P
IN
IAI
E
L
PE
F
D
P
S
V
--Y
ND
A
I
R
G
QH
LLA
M
K
A
L
RQ
KF
G
I
NE
N
-
-MT
HVE
K
G
L
P
E
E
V
I
P
D
LAE
H
L
Q
A
G
I
VV
L
G
TV
G
R
T
G
IS
A
A
F
LG
NT
A
EQ
VI
D
H
L
R
C
D
L
LV
IK
fig|340184.3.peg.198
Escherichia coli B7A (157-300/316)
LV
A
V
N
L
ASE
E
PYHNA
L
NE
K
L
V
K
ET
I
E
LA
E
Q
V
NH
T
EVHL
V
G
A
Y
P
VT
P
IN
IAI
E
L
PE
F
D
P
S
V
--Y
ND
A
I
R
G
QH
LLA
M
K
A
L
RQ
KF
G
I
NE
N
-
-MT
HVE
K
G
L
P
E
E
V
I
P
D
LAE
H
L
Q
A
G
I
VV
L
G
TV
G
R
T
G
IS
A
A
F
LG
NT
A
EQ
VI
D
H
L
R
C
D
L
LV
IK
fig|340184.6.peg.205
Escherichia coli B7A (157-300/316)
LV
A
V
N
L
ASE
E
PYHNA
L
NE
K
L
V
K
ET
I
E
LA
E
Q
V
NH
T
EVHL
V
G
A
Y
P
VT
P
IN
IAI
E
L
PE
F
D
P
S
V
--Y
ND
A
I
R
G
QH
LLA
M
K
A
L
RQ
KF
G
I
NE
N
-
-MT
HVE
K
G
L
P
E
E
V
I
P
D
LAE
H
L
Q
A
G
I
VV
L
G
TV
G
R
T
G
IS
A
A
F
LG
NT
A
EQ
VI
D
H
L
R
C
D
L
LV
IK
fig|511693.5.peg.1416
Escherichia coli BL21 (157-300/316)
LV
A
V
N
L
ASE
E
PYHNA
L
NE
K
L
V
K
ET
I
E
LA
E
Q
V
NH
T
EVHL
V
G
A
Y
P
VT
P
IN
IAI
E
L
PE
F
D
P
S
V
--Y
ND
A
I
R
G
QH
LLA
M
K
A
L
RQ
KF
G
I
NE
N
-
-MT
HVE
K
G
L
P
E
E
V
I
P
D
LAE
H
L
Q
A
G
I
VV
L
G
TV
G
R
T
G
IS
A
A
F
LG
NT
A
EQ
VI
D
H
L
R
C
D
L
LV
IK
fig|469008.4.peg.2355
Escherichia coli BL21(DE3) (157-300/316)
LV
A
V
N
L
ASE
E
PYHNA
L
NE
K
L
V
K
ET
I
E
LA
E
Q
V
NH
T
EVHL
V
G
A
Y
P
VT
P
IN
IAI
E
L
PE
F
D
P
S
V
--Y
ND
A
I
R
G
QH
LLA
M
K
A
L
RQ
KF
G
I
NE
N
-
-MT
HVE
K
G
L
P
E
E
V
I
P
D
LAE
H
L
Q
A
G
I
VV
L
G
TV
G
R
T
G
IS
A
A
F
LG
NT
A
EQ
VI
D
H
L
R
C
D
L
LV
IK
fig|595496.3.peg.1277
Escherichia coli BW2952 (157-300/316)
LV
A
V
N
L
ASE
E
PYHNA
L
NE
K
L
V
K
ET
I
E
LA
E
Q
V
NH
T
EVHL
V
G
A
Y
P
VT
P
IN
IAI
E
L
PE
F
D
P
S
V
--Y
ND
A
I
R
G
QH
LLA
M
K
A
L
RQ
KF
G
I
NE
N
-
-MT
HVE
K
G
L
P
E
E
V
I
P
D
LAE
H
L
Q
A
G
I
VV
L
G
TV
G
R
T
G
IS
A
A
F
LG
NT
A
EQ
VI
D
H
L
R
C
D
L
LV
IK
fig|199310.1.peg.1751
Escherichia coli CFT073 (157-300/316)
LV
A
V
N
L
ASE
E
PYHNA
L
NE
K
L
V
K
ET
I
E
LA
E
Q
V
NH
T
EVHL
V
G
A
Y
P
VT
P
IN
IAI
E
L
PE
F
D
P
S
V
--Y
ND
A
I
R
G
QH
LLA
M
K
A
L
RQ
KF
G
I
NE
N
-
-MT
HVE
K
G
L
P
E
E
V
I
P
D
LAE
H
L
Q
A
G
I
VV
L
G
TV
G
R
T
G
IS
A
A
F
LG
NT
A
EQ
VI
D
H
L
R
C
D
L
LV
IK
fig|199310.4.peg.1682
Escherichia coli CFT073 (157-300/316)
LV
A
V
N
L
ASE
E
PYHNA
L
NE
K
L
V
K
ET
I
E
LA
E
Q
V
NH
T
EVHL
V
G
A
Y
P
VT
P
IN
IAI
E
L
PE
F
D
P
S
V
--Y
ND
A
I
R
G
QH
LLA
M
K
A
L
RQ
KF
G
I
NE
N
-
-MT
HVE
K
G
L
P
E
E
V
I
P
D
LAE
H
L
Q
A
G
I
VV
L
G
TV
G
R
T
G
IS
A
A
F
LG
NT
A
EQ
VI
D
H
L
R
C
D
L
LV
IK
fig|536056.3.peg.2432
Escherichia coli DH1 (157-300/316)
LV
A
V
N
L
ASE
E
PYHNA
L
NE
K
L
V
K
ET
I
E
LA
E
Q
V
NH
T
EVHL
V
G
A
Y
P
VT
P
IN
IAI
E
L
PE
F
D
P
S
V
--Y
ND
A
I
R
G
QH
LLA
M
K
A
L
RQ
KF
G
I
NE
N
-
-MT
HVE
K
G
L
P
E
E
V
I
P
D
LAE
H
L
Q
A
G
I
VV
L
G
TV
G
R
T
G
IS
A
A
F
LG
NT
A
EQ
VI
D
H
L
R
C
D
L
LV
IK
fig|340186.3.peg.294
Escherichia coli E110019 (157-300/316)
LV
A
V
N
L
ASE
E
PYHNA
L
NE
K
L
V
K
ET
I
E
LA
E
Q
V
NH
T
EVHL
V
G
A
Y
P
VT
P
IN
IAI
E
L
PE
F
D
P
S
V
--Y
ND
A
I
R
G
QH
LLA
M
K
A
L
RQ
KF
G
I
NE
N
-
-MT
HVE
K
G
L
P
E
E
V
I
P
D
LAE
H
L
Q
A
G
I
VV
L
G
TV
G
R
T
G
IS
A
A
F
LG
NT
A
EQ
VI
D
H
L
R
C
D
L
LV
IK
fig|340186.5.peg.313
Escherichia coli E110019 (157-300/316)
LV
A
V
N
L
ASE
E
PYHNA
L
NE
K
L
V
K
ET
I
E
LA
E
Q
V
NH
T
EVHL
V
G
A
Y
P
VT
P
IN
IAI
E
L
PE
F
D
P
S
V
--Y
ND
A
I
R
G
QH
LLA
M
K
A
L
RQ
KF
G
I
NE
N
-
-MT
HVE
K
G
L
P
E
E
V
I
P
D
LAE
H
L
Q
A
G
I
VV
L
G
TV
G
R
T
G
IS
A
A
F
LG
NT
A
EQ
VI
D
H
L
R
C
D
L
LV
IK
fig|340185.3.peg.944
Escherichia coli E22 (157-300/316)
LV
A
V
N
L
ASE
E
PYHNA
L
NE
K
L
V
K
ET
I
E
LA
E
Q
V
NH
T
EVHL
V
G
A
Y
P
VT
P
IN
IAI
E
L
PE
F
D
P
S
V
--Y
ND
A
I
R
G
QH
LLA
M
K
A
L
RQ
KF
G
I
NE
N
-
-MT
HVE
K
G
L
P
E
E
V
I
P
D
LAE
H
L
Q
A
G
I
VV
L
G
TV
G
R
T
G
IS
A
A
F
LG
NT
A
EQ
VI
D
H
L
R
C
D
L
LV
IK
fig|340185.4.peg.987
Escherichia coli E22 (157-300/316)
LV
A
V
N
L
ASE
E
PYHNA
L
NE
K
L
V
K
ET
I
E
LA
E
Q
V
NH
T
EVHL
V
G
A
Y
P
VT
P
IN
IAI
E
L
PE
F
D
P
S
V
--Y
ND
A
I
R
G
QH
LLA
M
K
A
L
RQ
KF
G
I
NE
N
-
-MT
HVE
K
G
L
P
E
E
V
I
P
D
LAE
H
L
Q
A
G
I
VV
L
G
TV
G
R
T
G
IS
A
A
F
LG
NT
A
EQ
VI
D
H
L
R
C
D
L
LV
IK
fig|216593.1.peg.1974
Escherichia coli E2348/69 (166-309/325)
LV
A
V
N
L
ASE
E
PYHNA
L
NE
K
L
V
K
ET
I
E
LA
E
Q
V
NH
T
EVHL
V
G
A
Y
P
VT
P
IN
IAI
E
L
PE
F
D
P
S
V
--Y
ND
A
I
R
G
QH
LLA
M
K
A
L
RQ
KF
G
I
NE
N
-
-MT
HVE
K
G
L
P
E
E
V
I
P
D
LAE
H
L
Q
A
G
I
VV
L
G
TV
G
R
T
G
IS
A
A
F
LG
NT
A
EQ
VI
D
H
L
R
C
D
L
LV
IK
fig|331111.12.peg.1829
Escherichia coli E24377A (157-300/316)
LV
A
V
N
L
ASE
E
PYHNA
L
NE
K
L
V
K
E
M
I
E
LA
E
Q
V
NH
T
EVHL
V
G
A
Y
P
VT
P
IN
IAI
E
L
PE
F
D
P
S
V
--Y
ND
A
I
R
G
QH
LLA
M
K
A
L
RQ
KF
G
I
NE
N
-
-MT
HVE
K
G
L
P
E
E
V
I
P
D
LAE
H
L
Q
A
G
I
VV
L
G
TV
G
R
T
G
IS
A
A
F
LG
NT
A
EQ
VI
D
H
L
R
C
D
L
LV
IK
fig|331111.3.peg.3990
Escherichia coli E24377A (157-300/316)
LV
A
V
N
L
ASE
E
PYHNA
L
NE
K
L
V
K
E
M
I
E
LA
E
Q
V
NH
T
EVHL
V
G
A
Y
P
VT
P
IN
IAI
E
L
PE
F
D
P
S
V
--Y
ND
A
I
R
G
QH
LLA
M
K
A
L
RQ
KF
G
I
NE
N
-
-MT
HVE
K
G
L
P
E
E
V
I
P
D
LAE
H
L
Q
A
G
I
VV
L
G
TV
G
R
T
G
IS
A
A
F
LG
NT
A
EQ
VI
D
H
L
R
C
D
L
LV
IK
fig|562.375.peg.4242
Escherichia coli EC4100B (157-300/316)
LV
A
V
N
L
ASE
E
PYHNA
L
NE
K
L
V
K
ET
I
E
LA
E
Q
V
NH
T
EVHL
V
G
A
Y
P
VT
P
IN
IAI
E
L
PE
F
D
P
S
V
--Y
ND
A
I
R
G
QH
LLA
M
K
A
L
RQ
KF
G
I
NE
N
-
-MT
HVE
K
G
L
P
E
E
V
I
P
D
LAE
H
L
Q
A
G
I
VV
L
G
TV
G
R
T
G
IS
A
A
F
LG
NT
A
EQ
VI
D
H
L
R
C
D
L
LV
IK
fig|585397.7.peg.1551
Escherichia coli ED1a (157-300/316)
LV
A
V
N
L
ASE
E
PYHNA
L
NE
K
L
V
K
ET
I
E
LA
E
Q
V
NH
T
EVHL
V
G
A
Y
P
VT
P
IN
IAI
E
L
PE
F
D
P
S
V
--Y
ND
A
I
R
G
QH
LLA
M
K
A
L
RQ
KF
G
I
NE
N
-
-MT
HVE
K
G
L
P
E
E
V
I
P
D
LAE
H
L
Q
A
G
I
VV
L
G
TV
G
R
T
G
IS
A
A
F
LG
NT
A
EQ
VI
D
H
L
R
C
D
L
LV
IK
fig|585397.9.peg.1545
Escherichia coli ED1a (157-300/316)
LV
A
V
N
L
ASE
E
PYHNA
L
NE
K
L
V
K
ET
I
E
LA
E
Q
V
NH
T
EVHL
V
G
A
Y
P
VT
P
IN
IAI
E
L
PE
F
D
P
S
V
--Y
ND
A
I
R
G
QH
LLA
M
K
A
L
RQ
KF
G
I
NE
N
-
-MT
HVE
K
G
L
P
E
E
V
I
P
D
LAE
H
L
Q
A
G
I
VV
L
G
TV
G
R
T
G
IS
A
A
F
LG
NT
A
EQ
VI
D
H
L
R
C
D
L
LV
IK
fig|316401.4.peg.1653
Escherichia coli ETEC H10407 (157-300/316)
LV
A
V
N
L
ASE
E
PYHNA
L
NE
K
L
V
K
ET
I
E
LA
E
Q
V
NH
T
EVHL
V
G
A
Y
P
VT
P
IN
IAI
E
L
PE
F
D
P
S
V
--Y
ND
A
I
R
G
QH
LLA
M
K
A
L
RQ
KF
G
I
NE
N
-
-MT
HVE
K
G
L
P
E
E
V
I
P
D
LAE
H
L
Q
A
G
I
VV
L
G
TV
G
R
T
G
IS
A
A
F
LG
NT
A
EQ
VI
D
H
L
R
C
D
L
LV
IK
fig|340197.3.peg.1162
Escherichia coli F11 (157-300/316)
LV
A
V
N
L
ASE
E
PYHNA
L
NE
K
L
V
K
ET
I
E
LA
E
Q
V
NH
T
EVHL
V
G
A
Y
P
VT
P
IN
IAI
E
L
PE
F
D
P
S
V
--Y
ND
A
I
R
G
QH
LLA
M
K
A
L
RQ
KF
G
I
NE
N
-
-MT
HVE
K
G
L
P
E
E
V
I
P
D
LAE
H
L
Q
A
G
I
VV
L
G
TV
G
R
T
G
IS
A
A
F
LG
NT
A
EQ
VI
D
H
L
R
C
D
L
LV
IK
fig|340197.5.peg.1224
Escherichia coli F11 (157-300/316)
LV
A
V
N
L
ASE
E
PYHNA
L
NE
K
L
V
K
ET
I
E
LA
E
Q
V
NH
T
EVHL
V
G
A
Y
P
VT
P
IN
IAI
E
L
PE
F
D
P
S
V
--Y
ND
A
I
R
G
QH
LLA
M
K
A
L
RQ
KF
G
I
NE
N
-
-MT
HVE
K
G
L
P
E
E
V
I
P
D
LAE
H
L
Q
A
G
I
VV
L
G
TV
G
R
T
G
IS
A
A
F
LG
NT
A
EQ
VI
D
H
L
R
C
D
L
LV
IK
fig|656379.3.peg.3417
Escherichia coli FVEC1302 (157-300/316)
LV
A
V
N
L
ASE
E
PYHNA
L
NE
K
L
V
K
ET
I
E
LA
E
Q
V
NH
T
EVHL
V
G
A
Y
P
VT
P
IN
IAI
E
L
PE
F
D
P
S
V
--Y
ND
A
I
R
G
QH
LLA
M
K
A
L
RQ
KF
G
I
NE
N
-
-MT
HVE
K
G
L
P
E
E
V
I
P
D
LAE
H
L
Q
A
G
I
VV
L
G
TV
G
R
T
G
IS
A
A
F
LG
NT
A
EQ
VI
D
H
L
R
C
D
L
LV
IK
fig|656380.3.peg.2770
Escherichia coli FVEC1412 (157-300/316)
LV
A
V
N
L
ASE
E
PYHNA
L
NE
K
L
V
K
ET
I
E
LA
E
Q
V
NH
T
EVHL
V
G
A
Y
P
VT
P
IN
IAI
E
L
PE
F
D
P
S
V
--Y
ND
A
I
R
G
QH
LLA
M
K
A
L
RQ
KF
G
I
NE
N
-
-MT
HVE
K
G
L
P
E
E
V
I
P
D
LAE
H
L
Q
A
G
I
VV
L
G
TV
G
R
T
G
IS
A
A
F
LG
NT
A
EQ
VI
D
H
L
R
C
D
L
LV
IK
fig|656393.3.peg.2110
Escherichia coli H299 (157-300/316)
LV
A
V
N
L
ASE
E
PYHNA
L
NE
K
L
V
K
ET
I
E
LA
E
Q
V
NH
T
EVHL
V
G
A
Y
P
VT
P
IN
IAI
E
L
PE
F
D
P
S
V
--Y
ND
A
I
R
G
QH
LLA
M
K
A
L
RQ
KF
G
I
NE
N
-
-MT
HVE
K
G
L
P
E
E
V
I
P
D
LAE
H
L
Q
A
G
I
VV
L
G
TV
G
R
T
G
IS
A
A
F
LG
NT
A
EQ
VI
D
H
L
R
C
D
L
LV
IK
fig|656414.3.peg.1602
Escherichia coli H736 (157-300/316)
LV
A
V
N
L
ASE
E
PYHNA
L
NE
K
L
V
K
ET
I
E
LA
E
Q
V
NH
T
EVHL
V
G
A
Y
P
VT
P
IN
IAI
E
L
PE
F
D
P
S
V
--Y
ND
A
I
R
G
QH
LLA
M
K
A
L
RQ
KF
G
I
NE
N
-
-MT
HVE
K
G
L
P
E
E
V
I
P
D
LAE
H
L
Q
A
G
I
VV
L
G
TV
G
R
T
G
IS
A
A
F
LG
NT
A
EQ
VI
D
H
L
R
C
D
L
LV
IK
fig|331112.3.peg.1358
Escherichia coli HS (157-300/316)
LV
A
V
N
L
ASE
E
PYHNA
L
NE
K
L
V
K
ET
I
E
LA
E
Q
V
NH
T
EVHL
V
G
A
Y
P
VT
P
IN
IAI
E
L
PE
F
D
P
S
V
--Y
ND
A
I
R
G
QH
LLA
M
K
A
L
RQ
KF
G
I
NE
N
-
-MT
HVE
K
G
L
P
E
E
V
I
P
D
LAE
H
L
Q
A
G
I
VV
L
G
TV
G
R
T
G
IS
A
A
F
LG
NT
A
EQ
VI
D
H
L
R
C
D
L
LV
IK
fig|331112.6.peg.1413
Escherichia coli HS (157-300/316)
LV
A
V
N
L
ASE
E
PYHNA
L
NE
K
L
V
K
ET
I
E
LA
E
Q
V
NH
T
EVHL
V
G
A
Y
P
VT
P
IN
IAI
E
L
PE
F
D
P
S
V
--Y
ND
A
I
R
G
QH
LLA
M
K
A
L
RQ
KF
G
I
NE
N
-
-MT
HVE
K
G
L
P
E
E
V
I
P
D
LAE
H
L
Q
A
G
I
VV
L
G
TV
G
R
T
G
IS
A
A
F
LG
NT
A
EQ
VI
D
H
L
R
C
D
L
LV
IK
fig|585034.4.peg.1350
Escherichia coli IAI1 (157-300/316)
LV
A
V
N
L
ASE
E
PYHNA
L
NE
K
L
V
K
ET
I
E
LA
E
Q
V
NH
T
EVHL
V
G
A
Y
P
VT
P
IN
IAI
E
L
PE
F
D
P
S
V
--Y
ND
A
I
R
G
QH
LLA
M
K
A
L
RQ
KF
G
I
NE
N
-
-MT
HVE
K
G
L
P
E
E
V
I
P
D
LAE
H
L
Q
A
G
I
VV
L
G
TV
G
R
T
G
IS
A
A
F
LG
NT
A
EQ
VI
D
H
L
R
C
D
L
LV
IK
fig|585034.5.peg.1346
Escherichia coli IAI1 (157-300/316)
LV
A
V
N
L
ASE
E
PYHNA
L
NE
K
L
V
K
ET
I
E
LA
E
Q
V
NH
T
EVHL
V
G
A
Y
P
VT
P
IN
IAI
E
L
PE
F
D
P
S
V
--Y
ND
A
I
R
G
QH
LLA
M
K
A
L
RQ
KF
G
I
NE
N
-
-MT
HVE
K
G
L
P
E
E
V
I
P
D
LAE
H
L
Q
A
G
I
VV
L
G
TV
G
R
T
G
IS
A
A
F
LG
NT
A
EQ
VI
D
H
L
R
C
D
L
LV
IK
fig|585057.4.peg.1755
Escherichia coli IAI39 (157-300/316)
LV
A
V
N
L
ASE
E
PYHNA
L
NE
K
L
V
K
ET
I
E
LA
E
Q
V
NH
T
EVHL
V
G
A
Y
P
VT
P
IN
IAI
E
L
PE
F
D
P
S
V
--Y
ND
A
I
R
G
QH
LLA
M
K
A
L
RQ
KF
G
I
NE
N
-
-MT
HVE
K
G
L
P
E
E
V
I
P
D
LAE
H
L
Q
A
G
I
VV
L
G
TV
G
R
T
G
IS
A
A
F
LG
NT
A
EQ
VI
D
H
L
R
C
D
L
LV
IK
fig|585057.6.peg.1755
Escherichia coli IAI39 (157-300/316)
LV
A
V
N
L
ASE
E
PYHNA
L
NE
K
L
V
K
ET
I
E
LA
E
Q
V
NH
T
EVHL
V
G
A
Y
P
VT
P
IN
IAI
E
L
PE
F
D
P
S
V
--Y
ND
A
I
R
G
QH
LLA
M
K
A
L
RQ
KF
G
I
NE
N
-
-MT
HVE
K
G
L
P
E
E
V
I
P
D
LAE
H
L
Q
A
G
I
VV
L
G
TV
G
R
T
G
IS
A
A
F
LG
NT
A
EQ
VI
D
H
L
R
C
D
L
LV
IK
fig|714962.3.peg.1573
Escherichia coli IHE3034 (157-300/316)
LV
A
V
N
L
ASE
E
PYHNA
L
NE
K
L
V
K
ET
I
E
LA
E
Q
V
NH
T
EVHL
V
G
A
Y
P
VT
P
IN
IAI
E
L
PE
F
D
P
S
V
--Y
ND
A
I
R
G
QH
LLA
M
K
A
L
RQ
KF
G
I
NE
N
-
-MT
HVE
K
G
L
P
E
E
V
I
P
D
LAE
H
L
Q
A
G
I
VV
L
G
TV
G
R
T
G
IS
A
A
F
LG
NT
A
EQ
VI
D
H
L
R
C
D
L
LV
IK
fig|83333.1.peg.1322
Escherichia coli K12 (157-300/316)
LV
A
V
N
L
ASE
E
PYHNA
L
NE
K
L
V
K
ET
I
E
LA
E
Q
V
NH
T
EVHL
V
G
A
Y
P
VT
P
IN
IAI
E
L
PE
F
D
P
S
V
--Y
ND
A
I
R
G
QH
LLA
M
K
A
L
RQ
KF
G
I
NE
N
-
-MT
HVE
K
G
L
P
E
E
V
I
P
D
LAE
H
L
Q
A
G
I
VV
L
G
TV
G
R
T
G
IS
A
A
F
LG
NT
A
EQ
VI
D
H
L
R
C
D
L
LV
IK
fig|595495.4.peg.1048
Escherichia coli KO11 (157-300/316)
LV
A
V
N
L
ASE
E
PYHNA
L
NE
K
L
V
K
ET
I
E
LA
E
Q
V
NH
T
EVHL
V
G
A
Y
P
VT
P
IN
IAI
E
L
PE
F
D
P
S
V
--Y
ND
A
I
R
G
QH
LLA
M
K
A
L
RQ
KF
G
I
NE
N
-
-MT
HVE
K
G
L
P
E
E
V
I
P
D
LAE
H
L
Q
A
G
I
VV
L
G
TV
G
R
T
G
IS
A
A
F
LG
NT
A
EQ
VI
D
H
L
R
C
D
L
LV
IK
fig|656417.3.peg.1647
Escherichia coli M605 (157-300/316)
LV
A
V
N
L
ASE
E
PYHNA
L
NE
K
L
V
K
ET
I
E
LA
E
Q
V
NH
T
EVHL
V
G
A
Y
P
VT
P
IN
IAI
E
L
PE
F
D
P
S
V
--Y
ND
A
I
R
G
QH
LLA
M
K
A
L
RQ
KF
G
I
NE
N
-
-MT
HVE
K
G
L
P
E
E
V
I
P
D
LAE
H
L
Q
A
G
I
VV
L
G
TV
G
R
T
G
IS
A
A
F
LG
NT
A
EQ
VI
D
H
L
R
C
D
L
LV
IK
fig|656419.3.peg.1691
Escherichia coli M718 (157-300/316)
LV
A
V
N
L
ASE
E
PYHNA
L
NE
K
L
V
K
ET
I
E
LA
E
Q
V
NH
T
EVHL
V
G
A
Y
P
VT
P
IN
IAI
E
L
PE
F
D
P
S
V
--Y
ND
A
I
R
G
QH
LLA
M
K
A
L
RQ
KF
G
I
NE
N
-
-MT
HVE
K
G
L
P
E
E
V
I
P
D
LAE
H
L
Q
A
G
I
VV
L
G
TV
G
R
T
G
IS
A
A
F
LG
NT
A
EQ
VI
D
H
L
R
C
D
L
LV
IK
fig|679207.4.peg.3887
Escherichia coli MS 107-1 (157-300/316)
LV
A
V
N
L
ASE
E
PYHNA
L
NE
K
L
V
K
ET
I
E
LA
E
Q
V
NH
T
EVHL
V
G
A
Y
P
VT
P
IN
IAI
E
L
PE
F
D
P
S
V
--Y
ND
A
I
R
G
QH
LLA
M
K
A
L
RQ
KF
G
I
NE
N
-
-MT
HVE
K
G
L
P
E
E
V
I
P
D
LAE
H
L
Q
A
G
I
VV
L
G
TV
G
R
T
G
IS
A
A
F
LG
NT
A
EQ
VI
D
H
L
R
C
D
L
LV
IK
fig|749537.3.peg.329
Escherichia coli MS 115-1 (157-300/316)
LV
A
V
N
L
ASE
E
PYHNA
L
NE
K
L
V
K
ET
I
E
LA
E
Q
V
NH
T
EVHL
V
G
A
Y
P
VT
P
IN
IAI
E
L
PE
F
D
P
S
V
--Y
ND
A
I
R
G
QH
LLA
M
K
A
L
RQ
KF
G
I
NE
N
-
-MT
HVE
K
G
L
P
E
E
V
I
P
D
LAE
H
L
Q
A
G
I
VV
L
G
TV
G
R
T
G
IS
A
A
F
LG
NT
A
EQ
VI
D
H
L
R
C
D
L
LV
IK
fig|749538.3.peg.1842
Escherichia coli MS 116-1 (157-300/316)
LV
A
V
N
L
ASE
E
PYHNA
L
NE
K
L
V
K
ET
I
E
LA
E
Q
V
NH
T
EVHL
V
G
A
Y
P
VT
P
IN
IAI
E
L
PE
F
D
P
S
V
--Y
ND
A
I
R
G
QH
LLA
M
K
A
L
RQ
KF
G
I
NE
N
-
-MT
HVE
K
G
L
P
E
E
V
I
P
D
LAE
H
L
Q
A
G
I
VV
L
G
TV
G
R
T
G
IS
A
A
F
LG
NT
A
EQ
VI
D
H
L
R
C
D
L
LV
IK
fig|679206.4.peg.2272
Escherichia coli MS 119-7 (157-300/316)
LV
A
V
N
L
ASE
E
PYHNA
L
NE
K
L
V
K
ET
I
E
LA
E
Q
V
NH
T
EVHL
V
G
A
Y
P
VT
P
IN
IAI
E
L
PE
F
D
P
S
V
--Y
ND
A
I
R
G
QH
LLA
M
K
A
L
RQ
KF
G
I
NE
N
-
-MT
HVE
K
G
L
P
E
E
V
I
P
D
LAE
H
L
Q
A
G
I
VV
L
G
TV
G
R
T
G
IS
A
A
F
LG
NT
A
EQ
VI
D
H
L
R
C
D
L
LV
IK
fig|679205.4.peg.5383
Escherichia coli MS 124-1 (157-300/316)
LV
A
V
N
L
ASE
E
PYHNA
L
NE
K
L
V
K
ET
I
E
LA
E
Q
V
NH
T
EVHL
V
G
A
Y
P
VT
P
IN
IAI
E
L
PE
F
D
P
S
V
--Y
ND
A
I
R
G
QH
LLA
M
K
A
L
RQ
KF
G
I
NE
N
-
-MT
HVE
K
G
L
P
E
E
V
I
P
D
LAE
H
L
Q
A
G
I
VV
L
G
TV
G
R
T
G
IS
A
A
F
LG
NT
A
EQ
VI
D
H
L
R
C
D
L
LV
IK
fig|679204.3.peg.4034
Escherichia coli MS 145-7 (157-300/316)
LV
A
V
N
L
ASE
E
PYHNA
L
NE
K
L
V
K
ET
I
E
LA
E
Q
V
NH
T
EVHL
V
G
A
Y
P
VT
P
IN
IAI
E
L
PE
F
D
P
S
V
--Y
ND
A
I
R
G
QH
LLA
M
K
A
L
RQ
KF
G
I
NE
N
-
-MT
HVE
K
G
L
P
E
E
V
I
P
D
LAE
H
L
Q
A
G
I
VV
L
G
TV
G
R
T
G
IS
A
A
F
LG
NT
A
EQ
VI
D
H
L
R
C
D
L
LV
IK
fig|749540.3.peg.3542
Escherichia coli MS 146-1 (157-300/316)
LV
A
V
N
L
ASE
E
PYHNA
L
NE
K
L
V
K
ET
I
E
LA
E
Q
V
NH
T
EVHL
V
G
A
Y
P
VT
P
IN
IAI
E
L
PE
F
D
P
S
V
--Y
ND
A
I
R
G
QH
LLA
M
K
A
L
RQ
KF
G
I
NE
N
-
-MT
HVE
K
G
L
P
E
E
V
I
P
D
LAE
H
L
Q
A
G
I
VV
L
G
TV
G
R
T
G
IS
A
A
F
LG
NT
A
EQ
VI
D
H
L
R
C
D
L
LV
IK
fig|749544.3.peg.506
Escherichia coli MS 175-1 (157-300/316)
LV
A
V
N
L
ASE
E
PYHNA
L
NE
K
L
V
K
ET
I
E
LA
E
Q
V
NH
T
EVHL
V
G
A
Y
P
VT
P
IN
IAI
E
L
PE
F
D
P
S
V
--Y
ND
A
I
R
G
QH
LLA
M
K
A
L
RQ
KF
G
I
NE
N
-
-MT
HVE
K
G
L
P
E
E
V
I
P
D
LAE
H
L
Q
A
G
I
VV
L
G
TV
G
R
T
G
IS
A
A
F
LG
NT
A
EQ
VI
D
H
L
R
C
D
L
LV
IK
fig|749545.3.peg.4490
Escherichia coli MS 182-1 (157-300/316)
LV
A
V
N
L
ASE
E
PYHNA
L
NE
K
L
V
K
ET
I
E
LA
E
Q
V
NH
T
EVHL
V
G
A
Y
P
VT
P
IN
IAI
E
L
PE
F
D
P
S
V
--Y
ND
A
I
R
G
QH
LLA
M
K
A
L
RQ
KF
G
I
NE
N
-
-MT
HVE
K
G
L
P
E
E
V
I
P
D
LAE
H
L
Q
A
G
I
VV
L
G
TV
G
R
T
G
IS
A
A
F
LG
NT
A
EQ
VI
D
H
L
R
C
D
L
LV
IK
fig|749546.3.peg.308
Escherichia coli MS 185-1 (157-300/316)
LV
A
V
N
L
ASE
E
PYHNA
L
NE
K
L
V
K
ET
I
E
LA
E
Q
V
NH
T
EVHL
V
G
A
Y
P
VT
P
IN
IAI
E
L
PE
F
D
P
S
V
--Y
ND
A
I
R
G
QH
LLA
M
K
A
L
RQ
KF
G
I
NE
N
-
-MT
HVE
K
G
L
P
E
E
V
I
P
D
LAE
H
L
Q
A
G
I
VV
L
G
TV
G
R
T
G
IS
A
A
F
LG
NT
A
EQ
VI
D
H
L
R
C
D
L
LV
IK
fig|749547.3.peg.215
Escherichia coli MS 187-1 (157-300/316)
LV
A
V
N
L
ASE
E
PYHNA
L
NE
K
L
V
K
ET
I
E
LA
E
Q
V
NH
T
EVHL
V
G
A
Y
P
VT
P
IN
IAI
E
L
PE
F
D
P
S
V
--Y
ND
A
I
R
G
QH
LLA
M
K
A
L
RQ
KF
G
I
NE
N
-
-MT
HVE
K
G
L
P
E
E
V
I
P
D
LAE
H
L
Q
A
G
I
VV
L
G
TV
G
R
T
G
IS
A
A
F
LG
NT
A
EQ
VI
D
H
L
R
C
D
L
LV
IK
fig|749548.3.peg.1525
Escherichia coli MS 196-1 (157-300/316)
LV
A
V
N
L
ASE
E
PYHNA
L
NE
K
L
V
K
ET
I
E
LA
E
Q
V
NH
T
EVHL
V
G
A
Y
P
VT
P
IN
IAI
E
L
PE
F
D
P
S
V
--Y
ND
A
I
R
G
QH
LLA
M
K
A
L
RQ
KF
G
I
NE
N
-
-MT
HVE
K
G
L
P
E
E
V
I
P
D
LAE
H
L
Q
A
G
I
VV
L
G
TV
G
R
T
G
IS
A
A
F
LG
NT
A
EQ
VI
D
H
L
R
C
D
L
LV
IK
fig|749549.3.peg.1529
Escherichia coli MS 198-1 (157-300/316)
LV
A
V
N
L
ASE
E
PYHNA
L
NE
K
L
V
K
ET
I
E
LA
E
Q
V
NH
T
EVHL
V
G
A
Y
P
VT
P
IN
IAI
E
L
PE
F
D
P
S
V
--Y
ND
A
I
R
G
QH
LLA
M
K
A
L
RQ
KF
G
I
NE
N
-
-MT
HVE
K
G
L
P
E
E
V
I
P
D
LAE
H
L
Q
A
G
I
VV
L
G
TV
G
R
T
G
IS
A
A
F
LG
NT
A
EQ
VI
D
H
L
R
C
D
L
LV
IK
fig|749550.3.peg.105
Escherichia coli MS 200-1 (157-300/316)
LV
A
V
N
L
ASE
E
PYHNA
L
NE
K
L
V
K
ET
I
E
LA
E
Q
V
NH
T
EVHL
V
G
A
Y
P
VT
P
IN
IAI
E
L
PE
F
D
P
S
V
--Y
ND
A
I
R
G
QH
LLA
M
K
A
L
RQ
KF
G
I
NE
N
-
-MT
HVE
K
G
L
P
E
E
V
I
P
D
LAE
H
L
Q
A
G
I
VV
L
G
TV
G
R
T
G
IS
A
A
F
LG
NT
A
EQ
VI
D
H
L
R
C
D
L
LV
IK
fig|749527.3.peg.454
Escherichia coli MS 21-1 (157-300/316)
LV
A
V
N
L
ASE
E
PYHNA
L
NE
K
L
V
K
ET
I
E
LA
E
Q
V
NH
T
EVHL
V
G
A
Y
P
VT
P
IN
IAI
E
L
PE
F
D
P
S
V
--Y
ND
A
I
R
G
QH
LLA
M
K
A
L
RQ
KF
G
I
NE
N
-
-MT
HVE
K
G
L
P
E
E
V
I
P
D
LAE
H
L
Q
A
G
I
VV
L
G
TV
G
R
T
G
IS
A
A
F
LG
NT
A
EQ
VI
D
H
L
R
C
D
L
LV
IK
fig|749528.3.peg.133
Escherichia coli MS 45-1 (157-300/316)
LV
A
V
N
L
ASE
E
PYHNA
L
NE
K
L
V
K
ET
I
E
LA
E
Q
V
NH
T
EVHL
V
G
A
Y
P
VT
P
IN
IAI
E
L
PE
F
D
P
S
V
--Y
ND
A
I
R
G
QH
LLA
M
K
A
L
RQ
KF
G
I
NE
N
-
-MT
HVE
K
G
L
P
E
E
V
I
P
D
LAE
H
L
Q
A
G
I
VV
L
G
TV
G
R
T
G
IS
A
A
F
LG
NT
A
EQ
VI
D
H
L
R
C
D
L
LV
IK
fig|749531.3.peg.245
Escherichia coli MS 69-1 (157-300/316)
LV
A
V
N
L
ASE
E
PYHNA
L
NE
K
L
V
K
ET
I
E
LA
E
Q
V
NH
T
EVHL
V
G
A
Y
P
VT
P
IN
IAI
E
L
PE
F
D
P
S
V
--Y
ND
A
I
R
G
QH
LLA
M
K
A
L
RQ
KF
G
I
NE
N
-
-MT
HVE
K
G
L
P
E
E
V
I
P
D
LAE
H
L
Q
A
G
I
VV
L
G
TV
G
R
T
G
IS
A
A
F
LG
NT
A
EQ
VI
D
H
L
R
C
D
L
LV
IK
fig|749532.3.peg.1758
Escherichia coli MS 78-1 (157-300/316)
LV
A
V
N
L
ASE
E
PYHNA
L
NE
K
L
V
K
ET
I
E
LA
E
Q
V
NH
T
EVHL
V
G
A
Y
P
VT
P
IN
IAI
E
L
PE
F
D
P
S
V
--Y
ND
A
I
R
G
QH
LLA
M
K
A
L
RQ
KF
G
I
NE
N
-
-MT
HVE
K
G
L
P
E
E
V
I
P
D
LAE
H
L
Q
A
G
I
VV
L
G
TV
G
R
T
G
IS
A
A
F
LG
NT
A
EQ
VI
D
H
L
R
C
D
L
LV
IK
fig|753642.3.peg.1779
Escherichia coli NC101 (157-300/316)
LV
A
V
N
L
ASE
E
PYHNA
L
NE
K
L
V
K
ET
I
E
LA
E
Q
V
NH
T
EVHL
V
G
A
Y
P
VT
P
IN
IAI
E
L
PE
F
D
P
S
V
--Y
ND
A
I
R
G
QH
LLA
M
K
A
L
RQ
KF
G
I
NE
N
-
-MT
HVE
K
G
L
P
E
E
V
I
P
D
LAE
H
L
Q
A
G
I
VV
L
G
TV
G
R
T
G
IS
A
A
F
LG
NT
A
EQ
VI
D
H
L
R
C
D
L
LV
IK
fig|585395.4.peg.1572
Escherichia coli O103:H2 str. 12009 (157-300/316)
LV
A
V
N
L
ASE
E
PYHNA
L
NE
K
L
V
K
ET
I
E
LA
E
Q
V
NH
T
EVHL
V
G
A
Y
P
VT
P
IN
IAI
E
L
PE
F
D
P
S
V
--Y
ND
A
I
R
G
QH
LLA
M
K
A
L
RQ
KF
G
I
NE
N
-
-MT
HVE
K
G
L
P
E
E
V
I
P
D
LAE
H
L
Q
A
G
I
VV
L
G
TV
G
R
T
G
IS
A
A
F
LG
NT
A
EQ
VI
D
H
L
R
C
D
L
LV
IK
fig|585396.4.peg.1788
Escherichia coli O111:H- str. 11128 (157-300/316)
LV
A
V
N
L
ASE
E
PYHNA
L
NE
K
L
V
K
ET
I
E
LA
E
Q
V
NH
T
EVHL
V
G
A
Y
P
VT
P
IN
IAI
E
L
PE
F
D
P
S
V
--Y
ND
A
I
R
G
QH
LLA
M
K
A
L
RQ
KF
G
I
NE
N
-
-MT
HVE
K
G
L
P
E
E
V
I
P
D
LAE
H
L
Q
A
G
I
VV
L
G
TV
G
R
T
G
IS
A
A
F
LG
NT
A
EQ
VI
D
H
L
R
C
D
L
LV
IK
fig|574521.7.peg.1553
Escherichia coli O127:H6 str. E2348/69 (157-300/316)
LV
A
V
N
L
ASE
E
PYHNA
L
NE
K
L
V
K
ET
I
E
LA
E
Q
V
NH
T
EVHL
V
G
A
Y
P
VT
P
IN
IAI
E
L
PE
F
D
P
S
V
--Y
ND
A
I
R
G
QH
LLA
M
K
A
L
RQ
KF
G
I
NE
N
-
-MT
HVE
K
G
L
P
E
E
V
I
P
D
LAE
H
L
Q
A
G
I
VV
L
G
TV
G
R
T
G
IS
A
A
F
LG
NT
A
EQ
VI
D
H
L
R
C
D
L
LV
IK
fig|83334.1.peg.1943
Escherichia coli O157:H7 (157-300/316)
LV
A
V
N
L
ASE
E
PYHNA
L
NE
K
L
V
K
ET
I
E
LA
E
Q
V
NH
T
EVHL
V
G
A
Y
P
VT
P
IN
IAI
E
L
PE
F
D
P
S
V
--Y
ND
A
I
R
G
QH
LLA
M
K
A
L
RQ
KF
G
I
NE
N
-
-MT
HVE
K
G
L
P
E
E
V
I
P
D
LAE
H
L
Q
A
G
I
VV
L
G
TV
G
R
T
G
IS
A
A
F
LG
NT
A
EQ
VI
D
H
L
R
C
D
L
LV
IK
fig|155864.1.peg.2161
Escherichia coli O157:H7 EDL933 (157-300/316)
LV
A
V
N
L
ASE
E
PYHNA
L
NE
K
L
V
K
ET
I
E
LA
E
Q
V
NH
T
EVHL
V
G
A
Y
P
VT
P
IN
IAI
E
L
PE
F
D
P
S
V
--Y
ND
A
I
R
G
QH
LLA
M
K
A
L
RQ
KF
G
I
NE
N
-
-MT
HVE
K
G
L
P
E
E
V
I
P
D
LAE
H
L
Q
A
G
I
VV
L
G
TV
G
R
T
G
IS
A
A
F
LG
NT
A
EQ
VI
D
H
L
R
C
D
L
LV
IK
fig|155864.8.peg.1993
Escherichia coli O157:H7 EDL933 (157-300/316)
LV
A
V
N
L
ASE
E
PYHNA
L
NE
K
L
V
K
ET
I
E
LA
E
Q
V
NH
T
EVHL
V
G
A
Y
P
VT
P
IN
IAI
E
L
PE
F
D
P
S
V
--Y
ND
A
I
R
G
QH
LLA
M
K
A
L
RQ
KF
G
I
NE
N
-
-MT
HVE
K
G
L
P
E
E
V
I
P
D
LAE
H
L
Q
A
G
I
VV
L
G
TV
G
R
T
G
IS
A
A
F
LG
NT
A
EQ
VI
D
H
L
R
C
D
L
LV
IK
fig|444454.5.peg.313
Escherichia coli O157:H7 str. EC4024 (157-300/316)
LV
A
V
N
L
ASE
E
PYHNA
L
NE
K
L
V
K
ET
I
E
LA
E
Q
V
NH
T
EVHL
V
G
A
Y
P
VT
P
IN
IAI
E
L
PE
F
D
P
S
V
--Y
ND
A
I
R
G
QH
LLA
M
K
A
L
RQ
KF
G
I
NE
N
-
-MT
HVE
K
G
L
P
E
E
V
I
P
D
LAE
H
L
Q
A
G
I
VV
L
G
TV
G
R
T
G
IS
A
A
F
LG
NT
A
EQ
VI
D
H
L
R
C
D
L
LV
IK
fig|444449.5.peg.214
Escherichia coli O157:H7 str. EC4042 (157-300/316)
LV
A
V
N
L
ASE
E
PYHNA
L
NE
K
L
V
K
ET
I
E
LA
E
Q
V
NH
T
EVHL
V
G
A
Y
P
VT
P
IN
IAI
E
L
PE
F
D
P
S
V
--Y
ND
A
I
R
G
QH
LLA
M
K
A
L
RQ
KF
G
I
NE
N
-
-MT
HVE
K
G
L
P
E
E
V
I
P
D
LAE
H
L
Q
A
G
I
VV
L
G
TV
G
R
T
G
IS
A
A
F
LG
NT
A
EQ
VI
D
H
L
R
C
D
L
LV
IK
fig|444448.5.peg.4570
Escherichia coli O157:H7 str. EC4045 (157-300/316)
LV
A
V
N
L
ASE
E
PYHNA
L
NE
K
L
V
K
ET
I
E
LA
E
Q
V
NH
T
EVHL
V
G
A
Y
P
VT
P
IN
IAI
E
L
PE
F
D
P
S
V
--Y
ND
A
I
R
G
QH
LLA
M
K
A
L
RQ
KF
G
I
NE
N
-
-MT
HVE
K
G
L
P
E
E
V
I
P
D
LAE
H
L
Q
A
G
I
VV
L
G
TV
G
R
T
G
IS
A
A
F
LG
NT
A
EQ
VI
D
H
L
R
C
D
L
LV
IK
fig|444453.5.peg.4179
Escherichia coli O157:H7 str. EC4076 (157-300/316)
LV
A
V
N
L
ASE
E
PYHNA
L
NE
K
L
V
K
ET
I
E
LA
E
Q
V
NH
T
EVHL
V
G
A
Y
P
VT
P
IN
IAI
E
L
PE
F
D
P
S
V
--Y
ND
A
I
R
G
QH
LLA
M
K
A
L
RQ
KF
G
I
NE
N
-
-MT
HVE
K
G
L
P
E
E
V
I
P
D
LAE
H
L
Q
A
G
I
VV
L
G
TV
G
R
T
G
IS
A
A
F
LG
NT
A
EQ
VI
D
H
L
R
C
D
L
LV
IK
fig|444452.5.peg.2053
Escherichia coli O157:H7 str. EC4113 (157-300/316)
LV
A
V
N
L
ASE
E
PYHNA
L
NE
K
L
V
K
ET
I
E
LA
E
Q
V
NH
T
EVHL
V
G
A
Y
P
VT
P
IN
IAI
E
L
PE
F
D
P
S
V
--Y
ND
A
I
R
G
QH
LLA
M
K
A
L
RQ
KF
G
I
NE
N
-
-MT
HVE
K
G
L
P
E
E
V
I
P
D
LAE
H
L
Q
A
G
I
VV
L
G
TV
G
R
T
G
IS
A
A
F
LG
NT
A
EQ
VI
D
H
L
R
C
D
L
LV
IK
fig|444450.8.peg.2032
Escherichia coli O157:H7 str. EC4115 (157-300/316)
LV
A
V
N
L
ASE
E
PYHNA
L
NE
K
L
V
K
ET
I
E
LA
E
Q
V
NH
T
EVHL
V
G
A
Y
P
VT
P
IN
IAI
E
L
PE
F
D
P
S
V
--Y
ND
A
I
R
G
QH
LLA
M
K
A
L
RQ
KF
G
I
NE
N
-
-MT
HVE
K
G
L
P
E
E
V
I
P
D
LAE
H
L
Q
A
G
I
VV
L
G
TV
G
R
T
G
IS
A
A
F
LG
NT
A
EQ
VI
D
H
L
R
C
D
L
LV
IK
fig|444451.5.peg.2777
Escherichia coli O157:H7 str. EC4196 (157-300/316)
LV
A
V
N
L
ASE
E
PYHNA
L
NE
K
L
V
K
ET
I
E
LA
E
Q
V
NH
T
EVHL
V
G
A
Y
P
VT
P
IN
IAI
E
L
PE
F
D
P
S
V
--Y
ND
A
I
R
G
QH
LLA
M
K
A
L
RQ
KF
G
I
NE
N
-
-MT
HVE
K
G
L
P
E
E
V
I
P
D
LAE
H
L
Q
A
G
I
VV
L
G
TV
G
R
T
G
IS
A
A
F
LG
NT
A
EQ
VI
D
H
L
R
C
D
L
LV
IK
fig|444447.5.peg.5479
Escherichia coli O157:H7 str. EC4206 (157-300/316)
LV
A
V
N
L
ASE
E
PYHNA
L
NE
K
L
V
K
ET
I
E
LA
E
Q
V
NH
T
EVHL
V
G
A
Y
P
VT
P
IN
IAI
E
L
PE
F
D
P
S
V
--Y
ND
A
I
R
G
QH
LLA
M
K
A
L
RQ
KF
G
I
NE
N
-
-MT
HVE
K
G
L
P
E
E
V
I
P
D
LAE
H
L
Q
A
G
I
VV
L
G
TV
G
R
T
G
IS
A
A
F
LG
NT
A
EQ
VI
D
H
L
R
C
D
L
LV
IK
fig|478004.5.peg.2761
Escherichia coli O157:H7 str. EC4401 (157-300/316)
LV
A
V
N
L
ASE
E
PYHNA
L
NE
K
L
V
K
ET
I
E
LA
E
Q
V
NH
T
EVHL
V
G
A
Y
P
VT
P
IN
IAI
E
L
PE
F
D
P
S
V
--Y
ND
A
I
R
G
QH
LLA
M
K
A
L
RQ
KF
G
I
NE
N
-
-MT
HVE
K
G
L
P
E
E
V
I
P
D
LAE
H
L
Q
A
G
I
VV
L
G
TV
G
R
T
G
IS
A
A
F
LG
NT
A
EQ
VI
D
H
L
R
C
D
L
LV
IK
fig|478005.5.peg.3341
Escherichia coli O157:H7 str. EC4486 (110-253/269)
LV
A
V
N
L
ASE
E
PYHNA
L
NE
K
L
V
K
ET
I
E
LA
E
Q
V
NH
T
EVHL
V
G
A
Y
P
VT
P
IN
IAI
E
L
PE
F
D
P
S
V
--Y
ND
A
I
R
G
QH
LLA
M
K
A
L
RQ
KF
G
I
NE
N
-
-MT
HVE
K
G
L
P
E
E
V
I
P
D
LAE
H
L
Q
A
G
I
VV
L
G
TV
G
R
T
G
IS
A
A
F
LG
NT
A
EQ
VI
D
H
L
R
C
D
L
LV
IK
fig|478006.5.peg.3086
Escherichia coli O157:H7 str. EC4501 (157-300/316)
LV
A
V
N
L
ASE
E
PYHNA
L
NE
K
L
V
K
ET
I
E
LA
E
Q
V
NH
T
EVHL
V
G
A
Y
P
VT
P
IN
IAI
E
L
PE
F
D
P
S
V
--Y
ND
A
I
R
G
QH
LLA
M
K
A
L
RQ
KF
G
I
NE
N
-
-MT
HVE
K
G
L
P
E
E
V
I
P
D
LAE
H
L
Q
A
G
I
VV
L
G
TV
G
R
T
G
IS
A
A
F
LG
NT
A
EQ
VI
D
H
L
R
C
D
L
LV
IK
fig|478007.5.peg.2379
Escherichia coli O157:H7 str. EC508 (157-300/316)
LV
A
V
N
L
ASE
E
PYHNA
L
NE
K
L
V
K
ET
I
E
LA
E
Q
V
NH
T
EVHL
V
G
A
Y
P
VT
P
IN
IAI
E
L
PE
F
D
P
S
V
--Y
ND
A
I
R
G
QH
LLA
M
K
A
L
RQ
KF
G
I
NE
N
-
-MT
HVE
K
G
L
P
E
E
V
I
P
D
LAE
H
L
Q
A
G
I
VV
L
G
TV
G
R
T
G
IS
A
A
F
LG
NT
A
EQ
VI
D
H
L
R
C
D
L
LV
IK
fig|478008.5.peg.3527
Escherichia coli O157:H7 str. EC869 (157-300/316)
LV
A
V
N
L
ASE
E
PYHNA
L
NE
K
L
V
K
ET
I
E
LA
E
Q
V
NH
T
EVHL
V
G
A
Y
P
VT
P
IN
IAI
E
L
PE
F
D
P
S
V
--Y
ND
A
I
R
G
QH
LLA
M
K
A
L
RQ
KF
G
I
NE
N
-
-MT
HVE
K
G
L
P
E
E
V
I
P
D
LAE
H
L
Q
A
G
I
VV
L
G
TV
G
R
T
G
IS
A
A
F
LG
NT
A
EQ
VI
D
H
L
R
C
D
L
LV
IK
fig|637388.3.peg.1403
Escherichia coli O157:H7 str. FRIK2000 (157-300/316)
LV
A
V
N
L
ASE
E
PYHNA
L
NE
K
L
V
K
ET
I
E
LA
E
Q
V
NH
T
EVHL
V
G
A
Y
P
VT
P
IN
IAI
E
L
PE
F
D
P
S
V
--Y
ND
A
I
R
G
QH
LLA
M
K
A
L
RQ
KF
G
I
NE
N
-
-MT
HVE
K
G
L
P
E
E
V
I
P
D
LAE
H
L
Q
A
G
I
VV
L
G
TV
G
R
T
G
IS
A
A
F
LG
NT
A
EQ
VI
D
H
L
R
C
D
L
LV
IK
fig|570506.3.peg.3310
Escherichia coli O157:H7 str. FRIK966 (157-300/316)
LV
A
V
N
L
ASE
E
PYHNA
L
NE
K
L
V
K
ET
I
E
LA
E
Q
V
NH
T
EVHL
V
G
A
Y
P
VT
P
IN
IAI
E
L
PE
F
D
P
S
V
--Y
ND
A
I
R
G
QH
LLA
M
K
A
L
RQ
KF
G
I
NE
N
-
-MT
HVE
K
G
L
P
E
E
V
I
P
D
LAE
H
L
Q
A
G
I
VV
L
G
TV
G
R
T
G
IS
A
A
F
LG
NT
A
EQ
VI
D
H
L
R
C
D
L
LV
IK
fig|386585.9.peg.2020
Escherichia coli O157:H7 str. Sakai (157-300/316)
LV
A
V
N
L
ASE
E
PYHNA
L
NE
K
L
V
K
ET
I
E
LA
E
Q
V
NH
T
EVHL
V
G
A
Y
P
VT
P
IN
IAI
E
L
PE
F
D
P
S
V
--Y
ND
A
I
R
G
QH
LLA
M
K
A
L
RQ
KF
G
I
NE
N
-
-MT
HVE
K
G
L
P
E
E
V
I
P
D
LAE
H
L
Q
A
G
I
VV
L
G
TV
G
R
T
G
IS
A
A
F
LG
NT
A
EQ
VI
D
H
L
R
C
D
L
LV
IK
fig|544404.4.peg.1893
Escherichia coli O157:H7 str. TW14359 (157-300/316)
LV
A
V
N
L
ASE
E
PYHNA
L
NE
K
L
V
K
ET
I
E
LA
E
Q
V
NH
T
EVHL
V
G
A
Y
P
VT
P
IN
IAI
E
L
PE
F
D
P
S
V
--Y
ND
A
I
R
G
QH
LLA
M
K
A
L
RQ
KF
G
I
NE
N
-
-MT
HVE
K
G
L
P
E
E
V
I
P
D
LAE
H
L
Q
A
G
I
VV
L
G
TV
G
R
T
G
IS
A
A
F
LG
NT
A
EQ
VI
D
H
L
R
C
D
L
LV
IK
fig|502346.5.peg.5459
Escherichia coli O157:H7 str. TW14588 (157-300/316)
LV
A
V
N
L
ASE
E
PYHNA
L
NE
K
L
V
K
ET
I
E
LA
E
Q
V
NH
T
EVHL
V
G
A
Y
P
VT
P
IN
IAI
E
L
PE
F
D
P
S
V
--Y
ND
A
I
R
G
QH
LLA
M
K
A
L
RQ
KF
G
I
NE
N
-
-MT
HVE
K
G
L
P
E
E
V
I
P
D
LAE
H
L
Q
A
G
I
VV
L
G
TV
G
R
T
G
IS
A
A
F
LG
NT
A
EQ
VI
D
H
L
R
C
D
L
LV
IK
fig|573235.3.peg.1935
Escherichia coli O26:H11 str. 11368 (157-300/316)
LV
A
V
N
L
ASE
E
PYHNA
L
NE
K
L
V
K
ET
I
E
LA
E
Q
V
NH
T
EVHL
V
G
A
Y
P
VT
P
IN
IAI
E
L
PE
F
D
P
S
V
--Y
ND
A
I
R
G
QH
LLA
M
K
A
L
RQ
KF
G
I
NE
N
-
-MT
HVE
K
G
L
P
E
E
V
I
P
D
LAE
H
L
Q
A
G
I
VV
L
G
TV
G
R
T
G
IS
A
A
F
LG
NT
A
EQ
VI
D
H
L
R
C
D
L
LV
IK
fig|701177.3.peg.1676
Escherichia coli O55:H7 str. CB9615 (157-300/316)
LV
A
V
N
L
ASE
E
PYHNA
L
NE
K
L
V
K
ET
I
E
LA
E
Q
V
NH
T
EVHL
V
G
A
Y
P
VT
P
IN
IAI
E
L
PE
F
D
P
S
V
--Y
ND
A
I
R
G
QH
LLA
M
K
A
L
RQ
KF
G
I
NE
N
-
-MT
HVE
K
G
L
P
E
E
V
I
P
D
LAE
H
L
Q
A
G
I
VV
L
G
TV
G
R
T
G
IS
A
A
F
LG
NT
A
EQ
VI
D
H
L
R
C
D
L
LV
IK
fig|685038.3.peg.1376
Escherichia coli O83:H1 str. NRG 857C (157-300/316)
LV
A
V
N
L
ASE
E
PYHNA
L
NE
K
L
V
K
ET
I
E
LA
E
Q
V
NH
T
EVHL
V
G
A
Y
P
VT
P
IN
IAI
E
L
PE
F
D
P
S
V
--Y
ND
A
I
R
G
QH
LLA
M
K
A
L
RQ
KF
G
I
NE
N
-
-MT
HVE
K
G
L
P
E
E
V
I
P
D
LAE
H
L
Q
A
G
I
VV
L
G
TV
G
R
T
G
IS
A
A
F
LG
NT
A
EQ
VI
D
H
L
R
C
D
L
LV
IK
fig|637912.3.peg.4260
Escherichia coli OP50 (157-300/316)
LV
A
V
N
L
ASE
E
PYHNA
L
NE
K
L
V
K
ET
I
E
LA
E
Q
V
NH
T
EVHL
V
G
A
Y
P
VT
P
IN
IAI
E
L
PE
F
D
P
S
V
--Y
ND
A
I
R
G
QH
LLA
M
K
A
L
RQ
KF
G
I
NE
N
-
-MT
HVE
K
G
L
P
E
E
V
I
P
D
LAE
H
L
Q
A
G
I
VV
L
G
TV
G
R
T
G
IS
A
A
F
LG
NT
A
EQ
VI
D
H
L
R
C
D
L
LV
IK
fig|585035.6.peg.1466
Escherichia coli S88 (157-300/316)
LV
A
V
N
L
ASE
E
PYHNA
L
NE
K
L
V
K
ET
I
E
LA
E
Q
V
NH
T
EVHL
V
G
A
Y
P
VT
P
IN
IAI
E
L
PE
F
D
P
S
V
--Y
ND
A
I
R
G
QH
LLA
M
K
A
L
RQ
KF
G
I
NE
N
-
-MT
HVE
K
G
L
P
E
E
V
I
P
D
LAE
H
L
Q
A
G
I
VV
L
G
TV
G
R
T
G
IS
A
A
F
LG
NT
A
EQ
VI
D
H
L
R
C
D
L
LV
IK
fig|409438.11.peg.1525
Escherichia coli SE11 (157-300/316)
LV
A
V
N
L
ASE
E
PYHNA
L
NE
K
L
V
K
ET
I
E
LA
E
Q
V
NH
T
EVHL
V
G
A
Y
P
VT
P
IN
IAI
E
L
PE
F
D
P
S
V
--Y
ND
A
I
R
G
QH
LLA
M
K
A
L
RQ
KF
G
I
NE
N
-
-MT
HVE
K
G
L
P
E
E
V
I
P
D
LAE
H
L
Q
A
G
I
VV
L
G
TV
G
R
T
G
IS
A
A
F
LG
NT
A
EQ
VI
D
H
L
R
C
D
L
LV
IK
fig|431946.3.peg.1361
Escherichia coli SE15 (157-300/316)
LV
A
V
N
L
ASE
E
PYHNA
L
NE
K
L
V
K
ET
I
E
LA
E
Q
V
NH
T
EVHL
V
G
A
Y
P
VT
P
IN
IAI
E
L
PE
F
D
P
S
V
--Y
ND
A
I
R
G
QH
LLA
M
K
A
L
RQ
KF
G
I
NE
N
-
-MT
HVE
K
G
L
P
E
E
V
I
P
D
LAE
H
L
Q
A
G
I
VV
L
G
TV
G
R
T
G
IS
A
A
F
LG
NT
A
EQ
VI
D
H
L
R
C
D
L
LV
IK
fig|439855.10.peg.1945
Escherichia coli SMS-3-5 (157-300/316)
LV
A
V
N
L
ASE
E
PYHNA
L
NE
K
L
V
K
ET
I
E
LA
E
Q
V
NH
T
EVHL
V
G
A
Y
P
VT
P
IN
IAI
E
L
PE
F
D
P
S
V
--Y
ND
A
I
R
G
QH
LLA
M
K
A
L
RQ
KF
G
I
NE
N
-
-MT
HVE
K
G
L
P
E
E
V
I
P
D
LAE
H
L
Q
A
G
I
VV
L
G
TV
G
R
T
G
IS
A
A
F
LG
NT
A
EQ
VI
D
H
L
R
C
D
L
LV
IK
fig|656440.3.peg.1245
Escherichia coli TA206 (157-300/316)
LV
A
V
N
L
ASE
E
PYHNA
L
NE
K
L
V
K
ET
I
E
LA
E
Q
V
NH
T
EVHL
V
G
A
Y
P
VT
P
IN
IAI
E
L
PE
F
D
P
S
V
--Y
ND
A
I
R
G
QH
LLA
M
K
A
L
RQ
KF
G
I
NE
N
-
-MT
HVE
K
G
L
P
E
E
V
I
P
D
LAE
H
L
Q
A
G
I
VV
L
G
TV
G
R
T
G
IS
A
A
F
LG
NT
A
EQ
VI
D
H
L
R
C
D
L
LV
IK
fig|656443.3.peg.1676
Escherichia coli TA271 (157-300/316)
LV
A
V
N
L
ASE
E
PYHNA
L
NE
K
L
V
K
ET
I
E
LA
E
Q
V
NH
T
EVHL
V
G
A
Y
P
VT
P
IN
IAI
E
L
PE
F
D
P
S
V
--Y
ND
A
I
R
G
QH
LLA
M
K
A
L
RQ
KF
G
I
NE
N
-
-MT
HVE
K
G
L
P
E
E
V
I
P
D
LAE
H
L
Q
A
G
I
VV
L
G
TV
G
R
T
G
IS
A
A
F
LG
NT
A
EQ
VI
D
H
L
R
C
D
L
LV
IK
fig|656444.3.peg.2072
Escherichia coli TA280 (157-300/316)
LV
A
V
N
L
ASE
E
PYHNA
L
NE
K
L
V
K
ET
I
E
LA
E
Q
V
NH
T
EVHL
V
G
A
Y
P
VT
P
IN
IAI
E
L
PE
F
D
P
S
V
--Y
ND
A
I
R
G
QH
LLA
M
K
A
L
RQ
KF
G
I
NE
N
-
-MT
HVE
K
G
L
P
E
E
V
I
P
D
LAE
H
L
Q
A
G
I
VV
L
G
TV
G
R
T
G
IS
A
A
F
LG
NT
A
EQ
VI
D
H
L
R
C
D
L
LV
IK
fig|869729.3.peg.2148
Escherichia coli UM146 (157-300/316)
LV
A
V
N
L
ASE
E
PYHNA
L
NE
K
L
V
K
ET
I
E
LA
E
Q
V
NH
T
EVHL
V
G
A
Y
P
VT
P
IN
IAI
E
L
PE
F
D
P
S
V
--Y
ND
A
I
R
G
QH
LLA
M
K
A
L
RQ
KF
G
I
NE
N
-
-MT
HVE
K
G
L
P
E
E
V
I
P
D
LAE
H
L
Q
A
G
I
VV
L
G
TV
G
R
T
G
IS
A
A
F
LG
NT
A
EQ
VI
D
H
L
R
C
D
L
LV
IK
fig|585056.7.peg.1821
Escherichia coli UMN026 (157-300/316)
LV
A
V
N
L
ASE
E
PYHNA
L
NE
K
L
V
K
ET
I
E
LA
E
Q
V
NH
T
EVHL
V
G
A
Y
P
VT
P
IN
IAI
E
L
PE
F
D
P
S
V
--Y
ND
A
I
R
G
QH
LLA
M
K
A
L
RQ
KF
G
I
NE
N
-
-MT
HVE
K
G
L
P
E
E
V
I
P
D
LAE
H
L
Q
A
G
I
VV
L
G
TV
G
R
T
G
IS
A
A
F
LG
NT
A
EQ
VI
D
H
L
R
C
D
L
LV
IK
fig|364106.7.peg.1644
Escherichia coli UTI89 (157-300/316)
LV
A
V
N
L
ASE
E
PYHNA
L
NE
K
L
V
K
ET
I
E
LA
E
Q
V
NH
T
EVHL
V
G
A
Y
P
VT
P
IN
IAI
E
L
PE
F
D
P
S
V
--Y
ND
A
I
R
G
QH
LLA
M
K
A
L
RQ
KF
G
I
NE
N
-
-MT
HVE
K
G
L
P
E
E
V
I
P
D
LAE
H
L
Q
A
G
I
VV
L
G
TV
G
R
T
G
IS
A
A
F
LG
NT
A
EQ
VI
D
H
L
R
C
D
L
LV
IK
fig|364106.8.peg.1645
Escherichia coli UTI89 (157-300/316)
LV
A
V
N
L
ASE
E
PYHNA
L
NE
K
L
V
K
ET
I
E
LA
E
Q
V
NH
T
EVHL
V
G
A
Y
P
VT
P
IN
IAI
E
L
PE
F
D
P
S
V
--Y
ND
A
I
R
G
QH
LLA
M
K
A
L
RQ
KF
G
I
NE
N
-
-MT
HVE
K
G
L
P
E
E
V
I
P
D
LAE
H
L
Q
A
G
I
VV
L
G
TV
G
R
T
G
IS
A
A
F
LG
NT
A
EQ
VI
D
H
L
R
C
D
L
LV
IK
fig|566546.3.peg.164
Escherichia coli W (157-300/316)
LV
A
V
N
L
ASE
E
PYHNA
L
NE
K
L
V
K
ET
I
E
LA
E
Q
V
NH
T
EVHL
V
G
A
Y
P
VT
P
IN
IAI
E
L
PE
F
D
P
S
V
--Y
ND
A
I
R
G
QH
LLA
M
K
A
L
RQ
KF
G
I
NE
N
-
-MT
HVE
K
G
L
P
E
E
V
I
P
D
LAE
H
L
Q
A
G
I
VV
L
G
TV
G
R
T
G
IS
A
A
F
LG
NT
A
EQ
VI
D
H
L
R
C
D
L
LV
IK
fig|566546.4.peg.1425
Escherichia coli W (157-300/316)
LV
A
V
N
L
ASE
E
PYHNA
L
NE
K
L
V
K
ET
I
E
LA
E
Q
V
NH
T
EVHL
V
G
A
Y
P
VT
P
IN
IAI
E
L
PE
F
D
P
S
V
--Y
ND
A
I
R
G
QH
LLA
M
K
A
L
RQ
KF
G
I
NE
N
-
-MT
HVE
K
G
L
P
E
E
V
I
P
D
LAE
H
L
Q
A
G
I
VV
L
G
TV
G
R
T
G
IS
A
A
F
LG
NT
A
EQ
VI
D
H
L
R
C
D
L
LV
IK
fig|316407.3.peg.1297
Escherichia coli W3110 (157-300/316)
LV
A
V
N
L
ASE
E
PYHNA
L
NE
K
L
V
K
ET
I
E
LA
E
Q
V
NH
T
EVHL
V
G
A
Y
P
VT
P
IN
IAI
E
L
PE
F
D
P
S
V
--Y
ND
A
I
R
G
QH
LLA
M
K
A
L
RQ
KF
G
I
NE
N
-
-MT
HVE
K
G
L
P
E
E
V
I
P
D
LAE
H
L
Q
A
G
I
VV
L
G
TV
G
R
T
G
IS
A
A
F
LG
NT
A
EQ
VI
D
H
L
R
C
D
L
LV
IK
fig|562.376.peg.3121
Escherichia coli WV_060327 (157-300/316)
LV
A
V
N
L
ASE
E
PYHNA
L
NE
K
L
V
K
ET
I
E
LA
E
Q
V
NH
T
EVHL
V
G
A
Y
P
VT
P
IN
IAI
E
L
PE
F
D
P
S
V
--Y
ND
A
I
R
G
QH
LLA
M
K
A
L
RQ
KF
G
I
NE
N
-
-MT
HVE
K
G
L
P
E
E
V
I
P
D
LAE
H
L
Q
A
G
I
VV
L
G
TV
G
R
T
G
IS
A
A
F
LG
NT
A
EQ
VI
D
H
L
R
C
D
L
LV
IK
fig|316385.5.peg.1443
Escherichia coli str. K-12 substr. DH10B (157-300/316)
LV
A
V
N
L
ASE
E
PYHNA
L
NE
K
L
V
K
ET
I
E
LA
E
Q
V
NH
T
EVHL
V
G
A
Y
P
VT
P
IN
IAI
E
L
PE
F
D
P
S
V
--Y
ND
A
I
R
G
QH
LLA
M
K
A
L
RQ
KF
G
I
NE
N
-
-MT
HVE
K
G
L
P
E
E
V
I
P
D
LAE
H
L
Q
A
G
I
VV
L
G
TV
G
R
T
G
IS
A
A
F
LG
NT
A
EQ
VI
D
H
L
R
C
D
L
LV
IK
fig|316385.7.peg.1479
Escherichia coli str. K-12 substr. DH10B (157-300/316)
LV
A
V
N
L
ASE
E
PYHNA
L
NE
K
L
V
K
ET
I
E
LA
E
Q
V
NH
T
EVHL
V
G
A
Y
P
VT
P
IN
IAI
E
L
PE
F
D
P
S
V
--Y
ND
A
I
R
G
QH
LLA
M
K
A
L
RQ
KF
G
I
NE
N
-
-MT
HVE
K
G
L
P
E
E
V
I
P
D
LAE
H
L
Q
A
G
I
VV
L
G
TV
G
R
T
G
IS
A
A
F
LG
NT
A
EQ
VI
D
H
L
R
C
D
L
LV
IK
fig|511145.12.peg.1391
Escherichia coli str. K-12 substr. MG1655 (157-300/316)
LV
A
V
N
L
ASE
E
PYHNA
L
NE
K
L
V
K
ET
I
E
LA
E
Q
V
NH
T
EVHL
V
G
A
Y
P
VT
P
IN
IAI
E
L
PE
F
D
P
S
V
--Y
ND
A
I
R
G
QH
LLA
M
K
A
L
RQ
KF
G
I
NE
N
-
-MT
HVE
K
G
L
P
E
E
V
I
P
D
LAE
H
L
Q
A
G
I
VV
L
G
TV
G
R
T
G
IS
A
A
F
LG
NT
A
EQ
VI
D
H
L
R
C
D
L
LV
IK
fig|511145.6.peg.1380
Escherichia coli str. K-12 substr. MG1655 (157-300/316)
LV
A
V
N
L
ASE
E
PYHNA
L
NE
K
L
V
K
ET
I
E
LA
E
Q
V
NH
T
EVHL
V
G
A
Y
P
VT
P
IN
IAI
E
L
PE
F
D
P
S
V
--Y
ND
A
I
R
G
QH
LLA
M
K
A
L
RQ
KF
G
I
NE
N
-
-MT
HVE
K
G
L
P
E
E
V
I
P
D
LAE
H
L
Q
A
G
I
VV
L
G
TV
G
R
T
G
IS
A
A
F
LG
NT
A
EQ
VI
D
H
L
R
C
D
L
LV
IK
fig|749533.3.peg.2898
Escherichia coli MS 84-1 (157-300/316)
LV
A
V
N
L
ASE
E
PYHNA
L
NE
K
L
V
K
ET
I
E
LA
E
Q
V
NH
T
EVHL
V
G
A
Y
P
VT
P
IN
IAI
E
L
PE
F
D
P
S
V
--Y
ND
A
I
R
G
QH
LLA
M
K
A
L
RQ
KF
G
I
NE
N
-
-MT
HVE
K
G
L
P
E
E
V
I
P
D
LAE
H
L
Q
A
G
VVV
L
G
TV
G
R
T
G
IS
A
A
F
LG
NT
A
EQ
VI
D
H
L
R
C
D
L
LV
IK
Consen1
Primary consensus
MnrTIlvpvdl
E
-----
Lsdk
v
h
-
E
aq
dd
evHll
v
P
p
asl
L
f
a
v
nd
lq
ea
lq
m
kF
i
sr
HVe
Gsprd
i
eLAe
l
A
vvvigs
-
rp
Ist
lLGsnA
VirHa
c
vLVvr
Consen2
Secondary consensus
yk
imain
pyhna
r
i
et
ek
nh
vi
fv
a
-
iai
y
p
l
e
i
qh
m
h
l
-
r
lv
e
v
d
k
i
iilatv
nt
ta
f
nt
vd
l
l
l
ik
Consensus 1
(when a gap)
Conservative difference
Consensus 2
(when a gap)
Nonconservative diff.
Other character