fig|1040638.4.peg.4062
Escherichia coli O104:H4 str. LB226692
MNFHHLAYWQDKA
L
S
LAI
E
NR
L
F
ING
EYTAAAEN
---
ETFETV
D
P
V
T
QAP
L
AKIAR
G
KSV
D
I
D
R
AV
S
AA
RGV
F
ERGD
W
SLSS
P
AK
R
KAV
L
N
K
LA
D
L
M
E
AHAE
E
L
A
L
LE
TL
D
T
GK
PIRHSLRD
D
I
PGAARAIR
W
Y
A
E
AIDKVY
G
EVATTS
---
---SHELAMIV
R
E
P
V
GV
I
A
A
I
V
PWNFP
LL
L
TC
WK
LG
PALAAGN
S
VV
L
KPSE
K
S
PL
S
A
I
RL
A
G
L
AK
EAG
L
P
D
GV
L
NVV
T
G
F
G
HEA
G
QA
L
S
R
H
N
D
I
DA
IA
F
TGS
TR
TGK
Q
L
LKD
A
G
E
S
N
M
KRV
W
LE
A
GGKS
A
N
IV
FA
D
CP
D
-----
L
Q
K
A
ASATAAGIFY
N
Q
GQVC
IAGT
R
L
LLEESIA
D
E
F
LALLKQQAQNW
Q
P
G
HPLDPA
-
TTM
G
T
L
I
D
S
AH
A
D
S
V
HSF
I
RE
G
ESK
G
-
QL
L
LD
G
R
--
N--A
E
--
-
-
L
AA
AIG
PT
I
FVDVDPNAS
L
SR
EE
I
FGPVL
V
V
TRFTSE
DQ
A
L
QL
ANDSQYGL
G
A
A
V
W
T
R
DL
SR
A
H
R
M
S
RR
LK
A
G
SV
F
VN
NYNDGDMTV
P
F
GG
Y
K
Q
SG
N
G
RDK
S
LHA
L
EK
F
TEL
K
T
I
W
I
S
L
EA
fig|585055.6.peg.1492
Escherichia coli 55989
MNFHHLAYWQDKA
L
S
LAI
E
NR
L
F
ING
EYTAAAEN
---
ETFETV
D
P
V
T
QAP
L
AKIAR
G
KSV
D
I
D
R
AV
S
AA
RGV
F
ERGD
W
SLSS
P
AK
R
KAV
L
N
K
LA
D
L
M
E
AHAE
E
L
A
L
LE
TL
D
T
GK
PIRHSLRD
D
I
PGAARAIR
W
Y
A
E
AIDKVY
G
EVATTS
---
---SHELAMIV
R
E
P
V
GV
I
A
A
I
V
PWNFP
LL
L
TC
WK
LG
PALAAGN
S
VV
L
KPSE
K
S
PL
S
A
I
RL
A
G
L
AK
EAG
L
P
D
GV
L
NVV
T
G
F
G
HEA
G
QA
L
S
R
H
N
D
I
DA
IA
F
TGS
TR
TGK
Q
L
LKD
A
G
E
S
N
M
KRV
W
LE
A
GGKS
A
N
IV
FA
D
CP
D
-----
L
Q
K
A
ASATAAGIFY
N
Q
GQVC
IAGT
R
L
LLEESIA
D
E
F
LALLKQQAQNW
Q
P
G
HPLDPA
-
TTM
G
T
L
I
D
S
AH
A
D
S
V
HSF
I
RE
G
ESK
G
-
QL
L
LD
G
R
--
N--A
E
--
-
-
L
AA
AIG
PT
I
FVDVDPNAS
L
SR
EE
I
FGPVL
V
V
TRFTSE
DQ
A
L
QL
ANDSQYGL
G
A
A
V
W
T
R
DL
SR
A
H
R
M
S
RR
LK
A
G
SV
F
VN
NYNDGDMTV
P
F
GG
Y
K
Q
SG
N
G
RDK
S
LHA
L
EK
F
TEL
K
T
I
W
I
S
L
EA
fig|585055.8.peg.1493
Escherichia coli 55989
MNFHHLAYWQDKA
L
S
LAI
E
NR
L
F
ING
EYTAAAEN
---
ETFETV
D
P
V
T
QAP
L
AKIAR
G
KSV
D
I
D
R
AV
S
AA
RGV
F
ERGD
W
SLSS
P
AK
R
KAV
L
N
K
LA
D
L
M
E
AHAE
E
L
A
L
LE
TL
D
T
GK
PIRHSLRD
D
I
PGAARAIR
W
Y
A
E
AIDKVY
G
EVATTS
---
---SHELAMIV
R
E
P
V
GV
I
A
A
I
V
PWNFP
LL
L
TC
WK
LG
PALAAGN
S
VV
L
KPSE
K
S
PL
S
A
I
RL
A
G
L
AK
EAG
L
P
D
GV
L
NVV
T
G
F
G
HEA
G
QA
L
S
R
H
N
D
I
DA
IA
F
TGS
TR
TGK
Q
L
LKD
A
G
E
S
N
M
KRV
W
LE
A
GGKS
A
N
IV
FA
D
CP
D
-----
L
Q
K
A
ASATAAGIFY
N
Q
GQVC
IAGT
R
L
LLEESIA
D
E
F
LALLKQQAQNW
Q
P
G
HPLDPA
-
TTM
G
T
L
I
D
S
AH
A
D
S
V
HSF
I
RE
G
ESK
G
-
QL
L
LD
G
R
--
N--A
E
--
-
-
L
AA
AIG
PT
I
FVDVDPNAS
L
SR
EE
I
FGPVL
V
V
TRFTSE
DQ
A
L
QL
ANDSQYGL
G
A
A
V
W
T
R
DL
SR
A
H
R
M
S
RR
LK
A
G
SV
F
VN
NYNDGDMTV
P
F
GG
Y
K
Q
SG
N
G
RDK
S
LHA
L
EK
F
TEL
K
T
I
W
I
S
L
EA
fig|585034.4.peg.1314
Escherichia coli IAI1
MNFHHLAYWQDKA
L
S
LAI
E
NR
L
F
ING
EYTAAAEN
---
ETFETV
D
P
V
T
QAP
L
AKIAR
G
KSV
D
I
D
R
AV
S
AA
RGV
F
ERGD
W
SLSS
P
AK
R
KAV
L
N
K
LA
D
L
M
E
AHAE
E
L
A
L
LE
TL
D
T
GK
PIRHSLRD
D
I
PGAARAIR
W
Y
A
E
AIDKVY
G
EVATTS
---
---SHELAMIV
R
E
P
V
GV
I
A
A
I
V
PWNFP
LL
L
TC
WK
LG
PALAAGN
S
VV
L
KPSE
K
S
PL
S
A
I
RL
A
G
L
AK
EAG
L
P
D
GV
L
NVV
T
G
F
G
HEA
G
QA
L
S
R
H
N
D
I
DA
IA
F
TGS
TR
TGK
Q
L
LKD
A
G
E
S
N
M
KRV
W
LE
A
GGKS
A
N
IV
FA
D
CP
D
-----
L
Q
K
A
ASATAAGIFY
N
Q
GQVC
IAGT
R
L
LLEESIA
D
E
F
LALLKQQAQNW
Q
P
G
HPLDPA
-
TTM
G
T
L
I
D
S
AH
A
D
S
V
HSF
I
RE
G
ESK
G
-
QL
L
LD
G
R
--
N--A
E
--
-
-
L
AA
AIG
PT
I
FVDVDPNAS
L
SR
EE
I
FGPVL
V
V
TRFTSE
DQ
A
L
QL
ANDSQYGL
G
A
A
V
W
T
R
DL
SR
A
H
R
M
S
RR
LK
A
G
SV
F
VN
NYNDGDMTV
P
F
GG
Y
K
Q
SG
N
G
RDK
S
LHA
L
EK
F
TEL
K
T
I
W
I
S
L
EA
fig|585034.5.peg.1310
Escherichia coli IAI1
MNFHHLAYWQDKA
L
S
LAI
E
NR
L
F
ING
EYTAAAEN
---
ETFETV
D
P
V
T
QAP
L
AKIAR
G
KSV
D
I
D
R
AV
S
AA
RGV
F
ERGD
W
SLSS
P
AK
R
KAV
L
N
K
LA
D
L
M
E
AHAE
E
L
A
L
LE
TL
D
T
GK
PIRHSLRD
D
I
PGAARAIR
W
Y
A
E
AIDKVY
G
EVATTS
---
---SHELAMIV
R
E
P
V
GV
I
A
A
I
V
PWNFP
LL
L
TC
WK
LG
PALAAGN
S
VV
L
KPSE
K
S
PL
S
A
I
RL
A
G
L
AK
EAG
L
P
D
GV
L
NVV
T
G
F
G
HEA
G
QA
L
S
R
H
N
D
I
DA
IA
F
TGS
TR
TGK
Q
L
LKD
A
G
E
S
N
M
KRV
W
LE
A
GGKS
A
N
IV
FA
D
CP
D
-----
L
Q
K
A
ASATAAGIFY
N
Q
GQVC
IAGT
R
L
LLEESIA
D
E
F
LALLKQQAQNW
Q
P
G
HPLDPA
-
TTM
G
T
L
I
D
S
AH
A
D
S
V
HSF
I
RE
G
ESK
G
-
QL
L
LD
G
R
--
N--A
E
--
-
-
L
AA
AIG
PT
I
FVDVDPNAS
L
SR
EE
I
FGPVL
V
V
TRFTSE
DQ
A
L
QL
ANDSQYGL
G
A
A
V
W
T
R
DL
SR
A
H
R
M
S
RR
LK
A
G
SV
F
VN
NYNDGDMTV
P
F
GG
Y
K
Q
SG
N
G
RDK
S
LHA
L
EK
F
TEL
K
T
I
W
I
S
L
EA
fig|749545.3.peg.4457
Escherichia coli MS 182-1
MNFHHLAYWQDKA
L
S
LAI
E
NR
L
F
ING
EYTAAAEN
---
ETFETV
D
P
V
T
QAP
L
AKIAR
G
KSV
D
I
D
R
AV
S
AA
RGV
F
ERGD
W
SLSS
P
AK
R
KAV
L
N
K
LA
D
L
M
E
AHAE
E
L
A
L
LE
TL
D
T
GK
PIRHSLRD
D
I
PGAARAIR
W
Y
A
E
AIDKVY
G
EVATTS
---
---SHELAMIV
R
E
P
V
GV
I
A
A
I
V
PWNFP
LL
L
TC
WK
LG
PALAAGN
S
VV
L
KPSE
K
S
PL
S
A
I
RL
A
G
L
AK
EAG
L
P
D
GV
L
NVV
T
G
F
G
HEA
G
QA
L
S
R
H
N
D
I
DA
IA
F
TGS
TR
TGK
Q
L
LKD
A
G
E
S
N
M
KRV
W
LE
A
GGKS
A
N
IV
FA
D
CP
D
-----
L
Q
K
A
ASATAAGIFY
N
Q
GQVC
IAGT
R
L
LLEESIA
D
E
F
LALLKQQAQNW
Q
P
G
HPLDPA
-
TTM
G
T
L
I
D
S
AH
A
D
S
V
HSF
I
RE
G
ESK
G
-
QL
L
LD
G
R
--
N--A
E
--
-
-
L
AA
AIG
PT
I
FVDVDPNAS
L
SR
EE
I
FGPVL
V
V
TRFTSE
DQ
A
L
QL
ANDSQYGL
G
A
A
V
W
T
R
DL
SR
A
H
R
M
S
RR
LK
A
G
SV
F
VN
NYNDGDMTV
P
F
GG
Y
K
Q
SG
N
G
RDK
S
LHA
L
EK
F
TEL
K
T
I
W
I
S
L
EA
fig|749532.3.peg.1793
Escherichia coli MS 78-1
MNFHHLAYWQDKA
L
S
LAI
E
NR
L
F
ING
EYTAAAEN
---
ETFETV
D
P
V
T
QAP
L
AKIAR
G
KSV
D
I
D
R
AV
S
AA
RGV
F
ERGD
W
SLSS
P
AK
R
KAV
L
N
K
LA
D
L
M
E
AHAE
E
L
A
L
LE
TL
D
T
GK
PIRHSLRD
D
I
PGAARAIR
W
Y
A
E
AIDKVY
G
EVATTS
---
---SHELAMIV
R
E
P
V
GV
I
A
A
I
V
PWNFP
LL
L
TC
WK
LG
PALAAGN
S
VV
L
KPSE
K
S
PL
S
A
I
RL
A
G
L
AK
EAG
L
P
D
GV
L
NVV
T
G
F
G
HEA
G
QA
L
S
R
H
N
D
I
DA
IA
F
TGS
TR
TGK
Q
L
LKD
A
G
E
S
N
M
KRV
W
LE
A
GGKS
A
N
IV
FA
D
CP
D
-----
L
Q
K
A
ASATAAGIFY
N
Q
GQVC
IAGT
R
L
LLEESIA
D
E
F
LALLKQQAQNW
Q
P
G
HPLDPA
-
TTM
G
T
L
I
D
S
AH
A
D
S
V
HSF
I
RE
G
ESK
G
-
QL
L
LD
G
R
--
N--A
E
--
-
-
L
AA
AIG
PT
I
FVDVDPNAS
L
SR
EE
I
FGPVL
V
V
TRFTSE
DQ
A
L
QL
ANDSQYGL
G
A
A
V
W
T
R
DL
SR
A
H
R
M
S
RR
LK
A
G
SV
F
VN
NYNDGDMTV
P
F
GG
Y
K
Q
SG
N
G
RDK
S
LHA
L
EK
F
TEL
K
T
I
W
I
S
L
EA
fig|6666666.5357.peg.3276
Escherichia coli TY-2482
MNFHHLAYWQDKA
L
S
LAI
E
NR
L
F
ING
EYTAAAEN
---
ETFETV
D
P
V
T
QAP
L
AKIAR
G
KSV
D
I
D
R
AV
S
AA
RGV
F
ERGD
W
SLSS
P
AK
R
KAV
L
N
K
LA
D
L
M
E
AHAE
E
L
A
L
LE
TL
D
T
GK
PIRHSLRD
D
I
PGAARAIR
W
Y
A
E
AIDKVY
G
EVATTS
---
---SHELAMIV
R
E
P
V
GV
I
A
A
I
V
PWNFP
LL
L
TC
WK
LG
PALAAGN
S
VV
L
KPSE
K
S
PL
S
A
I
RL
A
G
L
AK
EAG
L
P
D
GV
L
NVV
T
G
F
G
HEA
G
QA
L
S
R
H
N
D
I
DA
IA
F
TGS
TR
TGK
Q
L
LKD
A
G
E
S
N
M
KRV
W
LE
A
GGKS
A
N
IV
FA
D
CP
D
-----
L
Q
K
A
ASATAAGIFY
N
Q
GQVC
IAGT
R
L
LLEESIA
D
E
F
LALLKQQAQNW
Q
P
G
HPLDPA
-
TTM
G
T
L
I
D
S
V
H
A
D
S
V
HSF
I
RE
G
ESK
G
-
QL
L
LD
G
R
--
N--A
E
--
-
-
L
AA
AIG
PT
I
FVDVDPNAS
L
SR
EE
I
FGPVL
V
V
TRFTSE
DQ
A
L
QL
ANDSQYGL
G
A
A
V
W
T
R
DL
SR
A
H
R
M
S
RR
LK
A
G
SV
F
VN
NYNDGDMTV
P
F
GG
Y
K
Q
SG
N
G
RDK
S
LHA
L
EK
F
TEL
K
T
I
W
I
S
L
EA
fig|550672.3.peg.785
Escherichia coli B088
MNFHHLAYWQDKA
L
S
LAI
E
NR
L
F
ING
EYTAAAEN
---
ETFETV
D
P
V
T
QAP
L
AKIAR
G
KSV
D
I
D
R
AV
S
AA
RGV
F
ERGD
W
SLSS
P
AK
R
KAV
L
N
K
LA
D
L
M
E
AHAE
E
L
A
L
LE
TL
D
T
GK
PIRHSLRD
D
I
PGAARAIR
W
Y
A
E
AIDKVY
G
EVATTS
---
---SHELAMIV
R
E
P
V
GV
I
A
A
I
V
PWNFP
LL
L
TC
WK
LG
PALAAGN
S
V
I
L
KPSE
K
S
PL
S
A
I
RL
A
G
L
AK
EAG
L
P
D
GV
L
NVV
T
G
F
G
HEA
G
QA
L
S
R
H
N
D
I
DA
IA
F
TGS
TR
TGK
Q
L
LKD
A
G
D
S
N
M
KRV
W
LE
A
GGKS
A
N
IV
FA
D
CP
D
-----
L
Q
K
A
ASATAAGIFY
N
Q
GQVC
IAGT
R
L
LLEESIA
D
E
F
LALLKQQAQNW
Q
P
G
HPLDPA
-
TTM
G
T
L
I
D
C
AH
A
D
S
V
HSF
I
RE
G
ESK
G
-
QL
L
LD
G
R
--
N--A
E
--
-
-
L
AA
AIG
PT
I
FVDVDPNAS
L
SR
EE
I
FGPVL
V
V
TRFTSE
DQ
A
L
QL
ANDSQYGL
G
A
A
V
W
T
R
DL
SR
A
H
R
M
S
RR
LK
A
G
SV
F
VN
NYNDGDMTV
P
F
GG
Y
K
Q
SG
N
G
RDK
S
LHA
L
EK
F
TEL
K
T
I
W
I
S
L
EA
fig|409438.11.peg.1490
Escherichia coli SE11
MNFHHLAYWQDKA
L
S
LAI
E
NR
L
F
ING
EYTAAAEN
---
ETFETV
D
P
V
T
QAP
L
AKIAR
G
KSV
D
I
D
R
AV
S
AA
RGV
F
ERGD
W
SLSS
P
AK
R
KAV
L
N
K
LA
D
L
M
E
AHAE
E
L
A
L
LE
TL
D
T
GK
PIRHSLRD
D
I
PGAARAIR
W
Y
A
E
AIDKVY
G
EVATTS
---
---SHELAMIV
R
E
P
V
GV
I
A
A
I
V
PWNFP
LL
L
TC
WK
LG
PALAAGN
S
V
I
L
KPSE
K
S
PL
S
A
I
RL
A
G
L
AK
EAG
L
P
D
GV
L
NVV
T
G
F
G
HEA
G
QA
L
S
R
H
N
D
I
DA
IA
F
TGS
TR
TGK
Q
L
LKD
A
G
D
S
N
M
KRV
W
LE
A
GGKS
A
N
IV
FA
D
CP
D
-----
L
Q
K
A
ASATAAGIFY
N
Q
GQVC
IAGT
R
L
LLEESIA
D
E
F
LALLKQQAQNW
Q
P
G
HPLDPA
-
TTM
G
T
L
I
D
C
AH
A
D
S
V
HSF
I
RE
G
ESK
G
-
QL
L
LD
G
R
--
N--A
E
--
-
-
L
AA
AIG
PT
I
FVDVDPNAS
L
SR
EE
I
FGPVL
V
V
TRFTSE
DQ
A
L
QL
ANDSQYGL
G
A
A
V
W
T
R
DL
SR
A
H
R
M
S
RR
LK
A
G
SV
F
VN
NYNDGDMTV
P
F
GG
Y
K
Q
SG
N
G
RDK
S
LHA
L
EK
F
TEL
K
T
I
W
I
S
L
EA
fig|585396.4.peg.1751
Escherichia coli O111:H- str. 11128
MNFHHLAYWQDKA
L
S
LAI
E
TR
L
F
ING
EYTAAAEN
---
ETFETV
D
P
V
T
QAP
L
AKIAR
G
KSV
D
I
D
R
AV
S
AA
RGV
F
ERGD
W
SLSS
P
AK
R
KAV
L
N
K
LT
D
L
M
E
AHAE
E
L
A
L
LE
TL
D
T
GK
PIRHSLRD
D
I
PGAARAIR
W
Y
A
E
AIDKVY
G
EVATTS
---
---SHELAMIV
R
E
P
V
GV
I
A
A
I
V
PWNFP
LL
L
TC
WK
LG
PALAAGN
S
VV
L
KPSE
K
S
PL
S
A
I
RL
A
G
L
AK
EAG
L
P
D
GV
L
NVV
T
G
F
G
HEA
G
QA
L
S
R
H
N
D
I
DA
IA
F
TGS
TR
TGK
Q
L
LKD
A
G
E
S
N
M
KRV
W
LE
A
GGKS
A
N
IV
FA
D
CP
D
-----
L
Q
K
A
ASATAAGIFY
N
Q
GQVC
IAGT
R
L
LLEESIA
D
E
F
LALLKQQAQNW
Q
P
G
HPLDPA
-
TTM
G
T
L
I
D
S
AH
A
D
S
V
HSF
I
RE
G
ESK
G
-
QL
L
LD
G
R
--
N--A
E
--
-
-
L
AA
AIG
PT
I
FVDVDPNAS
L
SR
EE
I
FGPVL
V
V
TRFTSE
DQ
A
L
QL
ANDSQYGL
G
A
A
V
W
T
R
DL
SR
A
H
R
M
S
RR
LK
A
G
SV
F
VN
NYNDGDMTV
P
F
GG
Y
K
Q
SG
N
G
RDK
S
LHA
L
EK
F
TEL
K
T
I
W
I
S
L
EA
fig|573235.3.peg.1898
Escherichia coli O26:H11 str. 11368
MNFHHLAYWQDKA
L
S
LAI
E
TR
L
F
ING
EYTAAAEN
---
ETFETV
D
P
V
T
QAP
L
AKIAR
G
KSV
D
I
D
R
AV
S
AA
RGV
F
ERGD
W
SLSS
P
AK
R
KAV
L
N
K
LT
D
L
M
E
AHAE
E
L
A
L
LE
TL
D
T
GK
PIRHSLRD
D
I
PGAARAIR
W
Y
A
E
AIDKVY
G
EVATTS
---
---SHELAMIV
R
E
P
V
GV
I
A
A
I
V
PWNFP
LL
L
TC
WK
LG
PALAAGN
S
VV
L
KPSE
K
S
PL
S
A
I
RL
A
G
L
AK
EAG
L
P
D
GV
L
NVV
T
G
F
G
HEA
G
QA
L
S
R
H
N
D
I
DA
IA
F
TGS
TR
TGK
Q
L
LKD
A
G
E
S
N
M
KRV
W
LE
A
GGKS
A
N
IV
FA
D
CP
D
-----
L
Q
K
A
ASATAAGIFY
N
Q
GQVC
IAGT
R
L
LLEESIA
D
E
F
LALLKQQAQNW
Q
P
G
HPLDPA
-
TTM
G
T
L
I
D
S
AH
A
D
S
V
HSF
I
RE
G
ESK
G
-
QL
L
LD
G
R
--
N--A
E
--
-
-
L
AA
AIG
PT
I
FVDVDPNAS
L
SR
EE
I
FGPVL
V
V
TRFTSE
DQ
A
L
QL
ANDSQYGL
G
A
A
V
W
T
R
DL
SR
A
H
R
M
S
RR
LK
A
G
SV
F
VN
NYNDGDMTV
P
F
GG
Y
K
Q
SG
N
G
RDK
S
LHA
L
EK
F
TEL
K
T
I
W
I
S
L
EA
fig|679207.4.peg.3924
Escherichia coli MS 107-1
MNFHHLAYWQDKA
L
S
LAI
E
NR
L
F
ING
EYTAAAEN
---
ETFETV
D
P
V
T
QAP
L
AKIAR
G
KSV
D
I
D
R
AV
S
AA
RGV
F
ERGD
W
SLSS
P
AK
R
KAV
L
N
K
LA
D
L
M
E
AHAE
E
L
A
L
LE
TL
D
T
GK
PIRHSLRD
D
I
PGAARAIR
W
Y
A
E
AIDKVY
G
EVATTS
---
---SHELAMIV
R
E
P
V
GV
I
A
A
I
V
PWNFP
LL
L
TC
WK
LG
PALAAGN
S
VV
L
KPSE
K
S
PL
S
A
I
RL
A
G
L
AK
EAG
L
P
D
GV
L
NVV
T
G
F
G
HEA
G
QA
L
S
R
H
N
D
I
DA
IA
F
TGS
TR
TGK
Q
L
LKD
A
G
D
S
N
M
KRV
W
LE
A
GGKS
A
N
L
V
FA
D
CP
D
-----
L
Q
K
A
ASATAAGIFY
N
Q
GQVC
IAGT
R
L
LLEESIA
D
E
F
LALLKQQAQNW
Q
P
G
HPLDPA
-
TTM
G
T
L
I
D
C
AH
A
D
S
V
HSF
I
RE
G
ESK
G
-
QL
L
LD
G
R
--
N--A
E
--
-
-
L
AA
AIG
PT
I
FVDVDPNAS
L
SR
EE
I
FGPVL
V
V
TRFTSE
DQ
A
L
QL
ANDSQYGL
G
A
A
V
W
T
R
DL
SR
A
H
R
M
S
RR
LK
A
G
SV
F
VN
NYNDGDMTV
P
F
GG
Y
K
Q
SG
N
G
RDK
S
LHA
L
EK
F
TEL
K
T
I
W
I
S
L
EA
fig|656408.3.peg.1380
Escherichia coli H591
MNFHHLAYWQDKA
L
S
LAI
E
NR
L
F
ING
EYTAAAEN
---
ETFETV
D
P
V
T
QAP
L
AKIAR
G
KSV
D
I
D
R
AV
S
AA
RGV
F
ERGD
W
SLSS
P
AK
R
KAV
L
N
K
LA
D
L
M
E
AHAE
E
L
A
L
LE
TL
D
T
GK
PIRHSLRD
D
I
PGAARAIR
W
Y
A
E
AIDKVY
G
EVATTS
---
---SHELAMIV
R
E
P
V
GV
I
A
A
I
V
PWNFP
LL
L
TC
WK
LG
PALAAGN
S
V
I
L
KPSE
K
S
PL
S
A
I
RL
A
G
L
AK
EAG
L
P
D
GV
L
NVV
T
G
F
G
HEA
G
QA
L
S
R
H
N
D
I
DA
IA
F
TGS
TR
TGK
Q
L
LKD
A
G
D
S
N
M
KRV
W
LE
A
GGKS
A
N
L
V
FA
D
CP
D
-----
L
Q
K
A
ASATAAGIFY
N
Q
GQVC
IAGT
R
L
LLEESIA
D
E
F
LALLKQQAQNW
Q
P
G
HPLDPA
-
TTM
G
T
L
I
D
C
AH
A
D
S
V
HSF
I
RE
G
ESK
G
-
QL
L
LD
G
R
--
N--A
E
--
-
-
L
AA
AIG
PT
I
FVDVDPNAS
L
SR
EE
I
FGPVL
V
V
TRFTSE
DQ
A
L
QL
ANDSQYGL
G
A
A
V
W
T
R
DL
SR
A
H
R
M
S
RR
LK
A
G
SV
F
VN
NYNDGDMTV
P
F
GG
Y
K
Q
SG
N
G
RDK
S
LHA
L
EK
F
TEL
K
T
I
W
I
S
L
EA
fig|679206.4.peg.2306
Escherichia coli MS 119-7
MNFHHLAYWQDKA
L
S
LAI
E
NR
L
F
ING
EYTAAAEN
---
ETFETV
D
P
V
T
QAP
L
AKIAR
G
KSV
D
I
D
R
AV
S
AA
RGV
F
ERGD
W
SLSS
P
AK
R
KAV
L
N
K
LA
D
L
M
E
AHAE
E
L
A
L
LE
TL
D
T
GK
PIRHSLRD
D
I
PGAARAIR
W
Y
A
E
AIDKVY
G
EVATTS
---
---SHELAMIV
R
E
P
V
GV
I
A
A
I
V
PWNFP
LL
L
TC
WK
LG
PALAAGN
S
V
I
L
KPSE
K
S
PL
S
A
I
RL
A
G
L
AK
EAG
L
P
D
GV
L
NVV
T
G
F
G
HEA
G
QA
L
S
R
H
N
D
I
DA
IA
F
TGS
TR
TGK
Q
L
LKD
A
G
D
S
N
M
KRV
W
LE
A
GGKS
A
N
L
V
FA
D
CP
D
-----
L
Q
K
A
ASATAAGIFY
N
Q
GQVC
IAGT
R
L
LLEESIA
D
E
F
LALLKQQAQNW
Q
P
G
HPLDPA
-
TTM
G
T
L
I
D
C
AH
A
D
S
V
HSF
I
RE
G
ESK
G
-
QL
L
LD
G
R
--
N--A
E
--
-
-
L
AA
AIG
PT
I
FVDVDPNAS
L
SR
EE
I
FGPVL
V
V
TRFTSE
DQ
A
L
QL
ANDSQYGL
G
A
A
V
W
T
R
DL
SR
A
H
R
M
S
RR
LK
A
G
SV
F
VN
NYNDGDMTV
P
F
GG
Y
K
Q
SG
N
G
RDK
S
LHA
L
EK
F
TEL
K
T
I
W
I
S
L
EA
fig|679205.4.peg.2840
Escherichia coli MS 124-1
MNFHHLAYWQDKA
L
S
LAI
E
NR
L
F
ING
EYTAAAEN
---
ETFETV
D
P
V
T
QAP
L
AKIAR
G
KSV
D
I
D
R
AV
S
AA
RGV
F
ERGD
W
SLSS
P
AK
R
KAV
L
N
K
LA
D
L
M
E
AHAE
E
L
A
L
LE
TL
D
T
GK
PIRHSLRD
D
I
PGAARAIR
W
Y
A
E
AIDKVY
G
EVATTS
---
---SHELAMIV
R
E
P
V
GV
I
A
A
I
V
PWNFP
LL
L
TC
WK
LG
PALAAGN
S
V
I
L
KPSE
K
S
PL
S
A
I
RL
A
G
L
AK
EAG
L
P
D
GV
L
NVV
T
G
F
G
HEA
G
QA
L
S
R
H
N
D
I
DA
IA
F
TGS
TR
TGK
Q
L
LKD
A
G
D
S
N
M
KRV
W
LE
A
GGKS
A
N
L
V
FA
D
CP
D
-----
L
Q
K
A
ASATAAGIFY
N
Q
GQVC
IAGT
R
L
LLEESIA
D
E
F
LALLKQQAQNW
Q
P
G
HPLDPA
-
TTM
G
T
L
I
D
C
AH
A
D
S
V
HSF
I
RE
G
ESK
G
-
QL
L
LD
G
R
--
N--A
E
--
-
-
L
AA
AIG
PT
I
FVDVDPNAS
L
SR
EE
I
FGPVL
V
V
TRFTSE
DQ
A
L
QL
ANDSQYGL
G
A
A
V
W
T
R
DL
SR
A
H
R
M
S
RR
LK
A
G
SV
F
VN
NYNDGDMTV
P
F
GG
Y
K
Q
SG
N
G
RDK
S
LHA
L
EK
F
TEL
K
T
I
W
I
S
L
EA
fig|749533.3.peg.2864
Escherichia coli MS 84-1
MNFHHLAYWQDKA
L
S
LAI
E
NR
L
F
ING
EYTAAAEN
---
ETFETV
D
P
V
T
QAP
L
AKIAR
G
KSV
D
I
D
R
AV
S
AA
RGV
F
ERGD
W
SLSS
P
AK
R
KAV
L
N
K
LA
D
L
M
E
AHAE
E
L
A
L
LE
TL
D
T
GK
PIRHSLRD
D
I
PGAARAIR
W
Y
A
E
AIDKVY
G
EVATTS
---
---SHELAMIV
R
E
P
V
GV
I
A
A
I
V
PWNFP
LL
L
TC
WK
LG
PALAAGN
S
V
I
L
KPSE
K
S
PL
S
A
I
RL
A
G
L
AK
EAG
L
P
D
GV
L
NVV
T
G
F
G
HEA
G
QA
L
S
R
H
N
D
I
DA
IA
F
TGS
TR
TGK
Q
L
LKD
A
G
D
S
N
M
KRV
W
LE
A
GGKS
A
N
L
V
FA
D
CP
D
-----
L
Q
K
A
ASATAAGIFY
N
Q
GQVC
IAGT
R
L
LLEESIA
D
E
F
LALLKQQAQNW
Q
P
G
HPLDPA
-
TTM
G
T
L
I
D
C
AH
A
D
S
V
HSF
I
RE
G
ESK
G
-
QL
L
LD
G
R
--
N--A
E
--
-
-
L
AA
AIG
PT
I
FVDVDPNAS
L
SR
EE
I
FGPVL
V
V
TRFTSE
DQ
A
L
QL
ANDSQYGL
G
A
A
V
W
T
R
DL
SR
A
H
R
M
S
RR
LK
A
G
SV
F
VN
NYNDGDMTV
P
F
GG
Y
K
Q
SG
N
G
RDK
S
LHA
L
EK
F
TEL
K
T
I
W
I
S
L
EA
fig|585395.4.peg.1536
Escherichia coli O103:H2 str. 12009
MNFHHLAYWQDKA
L
S
LAI
E
NR
L
F
ING
EYTAAAEN
---
ETFETV
D
P
V
T
QAP
L
AKIAR
G
KSV
D
I
D
R
AV
S
AA
RGV
F
ERGD
W
SLSS
P
AK
R
KAV
L
N
K
LA
D
L
M
E
AHAE
E
L
A
L
LE
TL
D
T
GK
PIRHSLRD
D
I
PGAARAIR
W
Y
A
E
AIDKVY
G
EVATTS
---
---SHELAMIV
R
E
P
V
GV
I
A
A
I
V
PWNFP
LL
L
TC
WK
LG
PALAAGN
S
V
I
L
KPSE
K
S
PL
S
A
I
RL
A
G
L
AK
EAG
L
P
D
GV
L
NVV
T
G
F
G
HEA
G
QA
L
S
R
H
N
D
I
DA
IA
F
TGS
TR
TGK
Q
L
LKD
A
G
D
S
N
M
KRV
W
LE
A
GGKS
A
N
L
V
FA
D
CP
D
-----
L
Q
K
A
ASATAAGIFY
N
Q
GQVC
IAGT
R
L
LLEESIA
D
E
F
LALLKQQAQNW
Q
P
G
HPLDPA
-
TTM
G
T
L
I
D
C
AH
A
D
S
V
HSF
I
RE
G
ESK
G
-
QL
L
LD
G
R
--
N--A
E
--
-
-
L
AA
AIG
PT
I
FVDVDPNAS
L
SR
EE
I
FGPVL
V
V
TRFTSE
DQ
A
L
QL
ANDSQYGL
G
A
A
V
W
T
R
DL
SR
A
H
R
M
S
RR
LK
A
G
SV
F
VN
NYNDGDMTV
P
F
GG
Y
K
Q
SG
N
G
RDK
S
LHA
L
EK
F
TEL
K
T
I
W
I
S
L
EA
fig|749537.3.peg.3039
Escherichia coli MS 115-1
MNFHHLAYWQDKA
L
S
LAI
E
NR
L
F
ING
EYTAAAEN
---
ETFETV
D
P
V
T
QAP
L
AKIAR
G
KSV
D
I
D
R
AV
S
AA
RGV
F
ERGD
W
SLSS
P
AK
R
KAV
L
N
K
LA
D
L
M
E
AHAE
E
L
A
L
LE
TL
D
T
GK
PIRHSLRD
D
I
PGAARAIR
W
Y
A
E
AIDKVY
G
EVATTS
---
---SHELAMIV
R
E
P
V
GV
I
A
A
I
V
PWNFP
LL
L
TC
WK
LG
PALAAGN
S
VV
L
KPSE
K
S
PL
S
A
I
RL
A
G
L
AK
EAG
L
P
D
GV
L
NVV
T
G
F
G
HEA
G
QA
L
S
R
H
N
D
I
DA
IA
F
TGS
TR
TGK
Q
L
LKD
A
G
D
S
N
M
KRV
W
LE
A
GGKS
A
N
IV
FA
D
CP
D
-----
L
Q
K
A
ASATAAGIFY
N
Q
GQVC
IAGT
R
L
LLEESIA
D
E
F
LALLKQQAQNW
Q
P
G
HPLDPA
-
TTM
G
T
L
I
D
C
AH
A
D
S
V
HSF
I
RE
G
ESK
G
-
QL
L
LD
G
R
--
N--A
E
--
-
-
L
AA
AIG
PT
I
FVDVDPNAS
L
SR
EE
I
FGPVL
V
V
TRFTSE
E
Q
A
L
QL
ANDSQYGL
G
A
A
V
W
T
R
DL
SR
A
H
R
M
S
RR
LK
A
G
SV
F
VN
NYNDGDMTV
P
F
GG
Y
K
Q
SG
N
G
RDK
S
LHA
L
EK
F
TEL
K
T
I
W
I
S
L
EA
fig|656443.3.peg.1637
Escherichia coli TA271
MNFHHLAYWQDKA
L
S
LAI
E
NR
L
F
ING
EYTAAAEN
---
ETFETV
D
P
V
T
QAP
L
AKIAR
G
KSV
D
I
D
R
AV
S
AA
RGV
F
ERGD
W
SLSS
P
AK
R
KAV
L
N
K
LA
D
L
M
E
AHAE
E
L
A
L
LE
TL
D
T
GK
PIRHSLRD
D
I
PGAARAIR
W
Y
A
E
AIDKVY
G
EVATTS
---
---SHELAMIV
R
E
P
V
GV
I
A
A
I
V
PWNFP
LL
L
TC
WK
LG
PALAAGN
S
V
I
L
KPSE
K
S
PL
S
A
I
RL
A
G
L
AK
EAG
L
P
D
GV
L
NVV
T
G
F
G
HEA
G
QA
L
S
R
H
N
D
I
DA
IA
F
TGS
TR
TGK
Q
L
LKD
A
G
D
S
N
M
KRV
W
LE
A
GGKS
A
N
L
V
FA
D
CP
D
-----
L
Q
K
A
ASATAAGIFY
N
Q
GQVC
IAGT
R
L
LLEESIA
D
E
F
LALLKQQAQNW
Q
P
G
HPLDPA
-
TTM
G
T
L
I
D
C
AH
A
D
S
V
HSF
I
RE
G
ESK
G
-
QL
L
LD
G
R
--
N--A
E
--
-
-
L
AA
AIG
PT
I
FVDADPNAS
L
SR
EE
I
FGPVL
V
V
TRFTSE
DQ
A
L
QL
ANDSQYGL
G
A
A
V
W
T
R
DL
SR
A
H
R
M
S
RR
LK
A
G
SV
F
VN
NYNDGDMTV
P
F
GG
Y
K
Q
SG
N
G
RDK
S
LHA
L
EK
F
TEL
K
T
I
W
I
S
L
EA
fig|481805.3.peg.2493
Escherichia coli ATCC 8739
MNFHHLAYWQDKA
L
S
LAI
E
NR
L
F
ING
EYTAAAEN
---
ETFETV
D
P
V
T
QAP
L
AKIAR
G
KSV
D
I
D
R
AV
S
AA
RGV
F
ERGD
W
SLSS
P
AK
R
KAV
L
N
K
LA
D
L
M
E
AHAE
E
L
A
L
LE
TL
D
T
GK
PIRHSLRD
D
I
PGAARAIR
W
Y
A
E
AIDKVY
G
EVATTS
---
---SHELAMIV
R
E
P
V
GV
I
A
A
I
V
PWNFP
LL
L
TC
WK
LG
PALAAGN
S
V
I
L
KPSE
K
S
PL
S
A
I
RL
A
G
L
AK
EAG
L
P
D
GV
L
NVV
T
G
F
G
HEA
G
QA
L
S
R
H
N
D
I
DA
IA
F
TGS
TR
TGK
Q
L
LKD
A
G
D
S
N
M
KRV
W
LE
A
GGKS
A
N
L
V
FA
D
CP
D
-----
L
Q
K
A
ASATAAGIFY
N
Q
GQVC
IAGT
R
L
LLEESIA
D
E
F
LALLKQQAQNW
Q
P
G
HPLDPA
-
TTM
G
T
L
I
D
C
AH
A
D
S
V
HSF
I
RE
G
ESK
G
-
QL
L
LD
G
R
--
N--A
E
--
-
-
L
AA
AIG
PT
I
FVDVDPNAS
L
SR
EE
I
FGPVL
V
V
TRFTSE
E
Q
A
L
QL
ANDSQYGL
G
A
A
V
W
T
R
DL
SR
A
H
R
M
S
RR
LK
A
G
SV
F
VN
NYNDGDMTV
P
F
GG
Y
K
Q
SG
N
G
RDK
S
LHA
L
EK
F
TEL
K
T
I
W
I
S
L
EA
fig|481805.6.peg.2483
Escherichia coli ATCC 8739
MNFHHLAYWQDKA
L
S
LAI
E
NR
L
F
ING
EYTAAAEN
---
ETFETV
D
P
V
T
QAP
L
AKIAR
G
KSV
D
I
D
R
AV
S
AA
RGV
F
ERGD
W
SLSS
P
AK
R
KAV
L
N
K
LA
D
L
M
E
AHAE
E
L
A
L
LE
TL
D
T
GK
PIRHSLRD
D
I
PGAARAIR
W
Y
A
E
AIDKVY
G
EVATTS
---
---SHELAMIV
R
E
P
V
GV
I
A
A
I
V
PWNFP
LL
L
TC
WK
LG
PALAAGN
S
V
I
L
KPSE
K
S
PL
S
A
I
RL
A
G
L
AK
EAG
L
P
D
GV
L
NVV
T
G
F
G
HEA
G
QA
L
S
R
H
N
D
I
DA
IA
F
TGS
TR
TGK
Q
L
LKD
A
G
D
S
N
M
KRV
W
LE
A
GGKS
A
N
L
V
FA
D
CP
D
-----
L
Q
K
A
ASATAAGIFY
N
Q
GQVC
IAGT
R
L
LLEESIA
D
E
F
LALLKQQAQNW
Q
P
G
HPLDPA
-
TTM
G
T
L
I
D
C
AH
A
D
S
V
HSF
I
RE
G
ESK
G
-
QL
L
LD
G
R
--
N--A
E
--
-
-
L
AA
AIG
PT
I
FVDVDPNAS
L
SR
EE
I
FGPVL
V
V
TRFTSE
E
Q
A
L
QL
ANDSQYGL
G
A
A
V
W
T
R
DL
SR
A
H
R
M
S
RR
LK
A
G
SV
F
VN
NYNDGDMTV
P
F
GG
Y
K
Q
SG
N
G
RDK
S
LHA
L
EK
F
TEL
K
T
I
W
I
S
L
EA
fig|656414.3.peg.1567
Escherichia coli H736
MNFHHLAYWQDKA
L
S
LAI
E
NR
L
F
ING
EYTAAAEN
---
ETFETV
D
P
V
T
QAP
L
AKIAR
G
KSV
D
I
D
R
AV
S
AA
RGV
F
ERGD
W
SLSS
P
AK
R
KAV
L
N
K
LA
D
L
M
E
AHAE
E
L
A
L
LE
TL
D
T
GK
PIRHSLRD
D
I
PGAARAIR
W
Y
A
E
AIDKVY
G
EVATTS
---
---SHELAMIV
R
E
P
V
GV
I
A
A
I
V
PWNFP
LL
L
TC
WK
LG
PALAAGN
S
V
I
L
KPSE
K
S
PL
S
A
I
RL
A
G
L
AK
EAG
L
P
D
GV
L
NVV
T
G
F
G
HEA
G
QA
L
S
R
H
N
D
I
DA
IA
F
TGS
TR
TGK
Q
L
LKD
A
G
D
S
N
M
KRV
W
LE
A
GGKS
A
N
L
V
FA
D
CP
D
-----
L
Q
K
A
ASATAAGIFY
N
Q
GQVC
IAGT
R
L
LLEESIA
D
E
F
LALLKQQAQNW
Q
P
G
HPLDPA
-
TTM
G
T
L
I
D
C
AH
A
D
S
V
HSF
I
RE
G
ESK
G
-
QL
L
LD
G
R
--
N--A
E
--
-
-
L
AA
AIG
PT
I
FVDVDPNAS
L
SR
EE
I
FGPVL
V
V
TRFTSE
E
Q
A
L
QL
ANDSQYGL
G
A
A
V
W
T
R
DL
SR
A
H
R
M
S
RR
LK
A
G
SV
F
VN
NYNDGDMTV
P
F
GG
Y
K
Q
SG
N
G
RDK
S
LHA
L
EK
F
TEL
K
T
I
W
I
S
L
EA
fig|749540.3.peg.3576
Escherichia coli MS 146-1
MNFHHLAYWQDKA
L
S
LAI
E
NR
L
F
ING
EYTAAAEN
---
ETFETV
D
P
V
T
QAP
L
AKIAR
G
KSV
D
I
D
R
AV
S
AA
RGV
F
ERGD
W
SLSS
P
AK
R
KAV
L
N
K
LA
D
L
M
E
AHAE
E
L
A
L
LE
TL
D
T
GK
PIRHSLRD
D
I
PGAARAIR
W
Y
A
E
AIDKVY
G
EVATTS
---
---SHELAMIV
R
E
P
V
GV
I
A
A
I
V
PWNFP
LL
L
TC
WK
LG
PALAAGN
S
V
I
L
KPSE
K
S
PL
S
A
I
RL
A
G
L
AK
EAG
L
P
D
GV
L
NVV
T
G
F
G
HEA
G
QA
L
S
R
H
N
D
I
DA
IA
F
TGS
TR
TGK
Q
L
LKD
A
G
D
S
N
M
KRV
W
LE
A
GGKS
A
N
L
V
FA
D
CP
D
-----
L
Q
K
A
ASATAAGIFY
N
Q
GQVC
IAGT
R
L
LLEESIA
D
E
F
LALLKQQAQNW
Q
P
G
HPLDPA
-
TTM
G
T
L
I
D
C
AH
A
D
S
V
HSF
I
RE
G
ESK
G
-
QL
L
LD
G
R
--
N--A
E
--
-
-
L
AA
AIG
PT
I
FVDVDPNAS
L
SR
EE
I
FGPVL
V
V
TRFTSE
E
Q
A
L
QL
ANDSQYGL
G
A
A
V
W
T
R
DL
SR
A
H
R
M
S
RR
LK
A
G
SV
F
VN
NYNDGDMTV
P
F
GG
Y
K
Q
SG
N
G
RDK
S
LHA
L
EK
F
TEL
K
T
I
W
I
S
L
EA
fig|344601.3.peg.132
Escherichia coli B171
MNFHHLAYWQDKA
L
S
LAI
E
NR
L
F
ING
EYTAAAEN
---
ETFETV
D
P
V
T
RAP
L
AKIAR
G
KSV
D
I
D
R
AV
S
AA
RGV
F
ERGD
W
SLSS
P
AK
R
KAV
L
N
K
LA
D
L
M
E
AHAE
E
L
A
L
LE
TL
D
T
GK
PIRHSLRD
D
I
PGAARAIR
W
Y
A
E
AIDKVY
G
EVATTS
---
---SHELAMIV
R
E
P
V
GV
I
A
A
I
V
PWNFP
LL
L
TC
WK
LG
PALAAGN
S
V
I
L
KPSE
K
S
PL
S
A
I
RL
A
G
L
AK
EAG
L
P
D
GV
L
NVV
T
G
F
G
HEA
G
QA
L
S
R
H
N
D
I
DA
IA
F
TGS
TR
TGK
Q
L
LKD
A
G
D
S
N
M
KRV
W
LE
A
GGKS
A
N
L
V
FA
D
CP
D
-----
L
Q
K
A
ASATAAGIFY
N
Q
GQVC
IAGT
R
L
LLEESIA
D
E
F
LALLKQQAQNW
Q
P
G
HPLDPA
-
TTM
G
T
L
I
D
C
AH
A
D
S
V
HSF
I
RE
G
ESK
G
-
QL
L
LD
G
R
--
N--A
E
--
-
-
L
AA
AIG
PT
I
FVDVDPNAS
L
SR
EE
I
FGPVL
V
V
TRFTSE
DQ
A
L
QL
ANDSQYGL
G
A
A
V
W
T
R
DL
SR
A
H
R
M
S
RR
LK
A
G
SV
F
VN
NYNDGDMTV
P
F
GG
Y
K
Q
SG
N
G
RDK
S
LHA
L
EK
F
TEL
K
T
I
W
I
S
L
EA
fig|344601.5.peg.128
Escherichia coli B171
MNFHHLAYWQDKA
L
S
LAI
E
NR
L
F
ING
EYTAAAEN
---
ETFETV
D
P
V
T
RAP
L
AKIAR
G
KSV
D
I
D
R
AV
S
AA
RGV
F
ERGD
W
SLSS
P
AK
R
KAV
L
N
K
LA
D
L
M
E
AHAE
E
L
A
L
LE
TL
D
T
GK
PIRHSLRD
D
I
PGAARAIR
W
Y
A
E
AIDKVY
G
EVATTS
---
---SHELAMIV
R
E
P
V
GV
I
A
A
I
V
PWNFP
LL
L
TC
WK
LG
PALAAGN
S
V
I
L
KPSE
K
S
PL
S
A
I
RL
A
G
L
AK
EAG
L
P
D
GV
L
NVV
T
G
F
G
HEA
G
QA
L
S
R
H
N
D
I
DA
IA
F
TGS
TR
TGK
Q
L
LKD
A
G
D
S
N
M
KRV
W
LE
A
GGKS
A
N
L
V
FA
D
CP
D
-----
L
Q
K
A
ASATAAGIFY
N
Q
GQVC
IAGT
R
L
LLEESIA
D
E
F
LALLKQQAQNW
Q
P
G
HPLDPA
-
TTM
G
T
L
I
D
C
AH
A
D
S
V
HSF
I
RE
G
ESK
G
-
QL
L
LD
G
R
--
N--A
E
--
-
-
L
AA
AIG
PT
I
FVDVDPNAS
L
SR
EE
I
FGPVL
V
V
TRFTSE
DQ
A
L
QL
ANDSQYGL
G
A
A
V
W
T
R
DL
SR
A
H
R
M
S
RR
LK
A
G
SV
F
VN
NYNDGDMTV
P
F
GG
Y
K
Q
SG
N
G
RDK
S
LHA
L
EK
F
TEL
K
T
I
W
I
S
L
EA
fig|340185.3.peg.909
Escherichia coli E22
MNFHHLAYWQDKA
L
S
LAI
E
NR
L
F
ING
EYTAAAEN
---
ETFETV
D
P
V
T
QAP
L
AKIAR
G
KSV
D
I
D
R
AV
R
AA
RGV
F
ERGD
W
SLSS
P
AK
R
KAV
L
N
K
LA
D
L
M
E
AHAE
E
L
A
L
LE
TL
D
T
GK
PIRHSLRD
D
I
PGAARAIR
W
Y
A
E
AIDKVY
G
EVATTS
---
---SHELAMIV
R
E
P
V
GV
I
A
A
I
V
PWNFP
LL
L
TC
WK
LG
PALAAGN
S
V
I
L
KPSE
K
S
PL
S
A
I
RL
A
G
L
AK
EAG
L
P
D
GV
L
NVV
T
G
F
G
HEA
G
QA
L
S
R
H
N
D
I
DA
IA
F
TGS
TR
TGK
Q
L
LKD
A
G
D
S
N
M
KRV
W
LE
A
GGKS
A
N
L
V
FA
D
CP
D
-----
L
Q
K
A
ASATAAGIFY
N
Q
GQVC
IAGT
R
L
LLEESIA
D
E
F
LALLKQQAQNW
Q
P
G
HPLDPA
-
TTM
G
T
L
I
D
C
AH
A
D
S
V
HSF
I
RE
G
ESK
G
-
QL
L
LD
G
R
--
N--A
E
--
-
-
L
AA
AIG
PT
I
FVDIDPNAS
L
SR
EE
I
FGPVL
V
V
TRFTSE
DQ
A
L
QL
ANDSQYGL
G
A
A
V
W
T
R
DL
SR
A
H
R
M
S
RR
LK
A
G
SV
F
VN
NYNDGDMTV
P
F
GG
Y
K
Q
SG
N
G
RDK
S
LHA
L
EK
F
TEL
K
T
I
W
I
S
L
EA
fig|340185.4.peg.952
Escherichia coli E22
MNFHHLAYWQDKA
L
S
LAI
E
NR
L
F
ING
EYTAAAEN
---
ETFETV
D
P
V
T
QAP
L
AKIAR
G
KSV
D
I
D
R
AV
R
AA
RGV
F
ERGD
W
SLSS
P
AK
R
KAV
L
N
K
LA
D
L
M
E
AHAE
E
L
A
L
LE
TL
D
T
GK
PIRHSLRD
D
I
PGAARAIR
W
Y
A
E
AIDKVY
G
EVATTS
---
---SHELAMIV
R
E
P
V
GV
I
A
A
I
V
PWNFP
LL
L
TC
WK
LG
PALAAGN
S
V
I
L
KPSE
K
S
PL
S
A
I
RL
A
G
L
AK
EAG
L
P
D
GV
L
NVV
T
G
F
G
HEA
G
QA
L
S
R
H
N
D
I
DA
IA
F
TGS
TR
TGK
Q
L
LKD
A
G
D
S
N
M
KRV
W
LE
A
GGKS
A
N
L
V
FA
D
CP
D
-----
L
Q
K
A
ASATAAGIFY
N
Q
GQVC
IAGT
R
L
LLEESIA
D
E
F
LALLKQQAQNW
Q
P
G
HPLDPA
-
TTM
G
T
L
I
D
C
AH
A
D
S
V
HSF
I
RE
G
ESK
G
-
QL
L
LD
G
R
--
N--A
E
--
-
-
L
AA
AIG
PT
I
FVDIDPNAS
L
SR
EE
I
FGPVL
V
V
TRFTSE
DQ
A
L
QL
ANDSQYGL
G
A
A
V
W
T
R
DL
SR
A
H
R
M
S
RR
LK
A
G
SV
F
VN
NYNDGDMTV
P
F
GG
Y
K
Q
SG
N
G
RDK
S
LHA
L
EK
F
TEL
K
T
I
W
I
S
L
EA
fig|595495.4.peg.1083
Escherichia coli KO11
MNFHHLAYWQDKA
L
S
LAI
E
NR
L
F
ING
EYTAAAEN
---
ETFETV
D
P
V
T
QAP
L
AKIAR
G
KSV
D
I
D
R
AV
S
AA
RGV
F
ERGD
W
SLSS
P
AK
R
KAV
L
N
K
LA
D
L
M
E
AHAE
E
L
A
L
LE
TL
D
T
GK
PIRHSLRD
D
I
PGAARAIR
W
Y
A
E
AIDKVY
G
EVATTS
---
---SHELAMIV
R
E
P
V
GV
I
A
A
I
V
PWNFP
LL
L
TC
WK
LG
PALAAGN
S
VV
L
KPSE
K
S
PL
S
A
I
RL
A
G
L
AK
EAG
L
P
D
GV
L
NVV
T
G
F
G
HEA
G
QA
L
S
R
H
N
D
I
DA
IA
F
TGS
TR
TGK
Q
L
LKD
A
G
E
S
N
M
KRV
W
LE
A
GGKS
A
N
IV
FA
D
CP
D
-----
L
Q
K
A
ASATAAGIFY
N
Q
GQVC
IAGT
R
L
LLEESIA
D
E
F
LALLKQQAQNW
Q
P
G
HPLDPA
-
TTM
G
T
L
I
D
S
AH
A
D
S
V
HTF
I
RE
G
EGK
G
-
QL
L
LD
G
R
--
N--A
G
--
-
-
L
AA
AIG
PT
I
FVDVDPNAS
L
SR
EE
I
FGPVL
V
V
TRFTSE
E
Q
A
L
QL
ANDSQYGL
G
A
A
V
W
T
R
DL
SR
A
H
R
M
S
RR
LK
A
G
SV
F
VN
NYNDGDMTV
P
F
GG
Y
K
Q
SG
N
G
RDK
S
LHA
L
EK
F
TEL
K
T
I
W
I
S
L
EA
fig|566546.3.peg.199
Escherichia coli W
MNFHHLAYWQDKA
L
S
LAI
E
NR
L
F
ING
EYTAAAEN
---
ETFETV
D
P
V
T
QAP
L
AKIAR
G
KSV
D
I
D
R
AV
S
AA
RGV
F
ERGD
W
SLSS
P
AK
R
KAV
L
N
K
LA
D
L
M
E
AHAE
E
L
A
L
LE
TL
D
T
GK
PIRHSLRD
D
I
PGAARAIR
W
Y
A
E
AIDKVY
G
EVATTS
---
---SHELAMIV
R
E
P
V
GV
I
A
A
I
V
PWNFP
LL
L
TC
WK
LG
PALAAGN
S
VV
L
KPSE
K
S
PL
S
A
I
RL
A
G
L
AK
EAG
L
P
D
GV
L
NVV
T
G
F
G
HEA
G
QA
L
S
R
H
N
D
I
DA
IA
F
TGS
TR
TGK
Q
L
LKD
A
G
E
S
N
M
KRV
W
LE
A
GGKS
A
N
IV
FA
D
CP
D
-----
L
Q
K
A
ASATAAGIFY
N
Q
GQVC
IAGT
R
L
LLEESIA
D
E
F
LALLKQQAQNW
Q
P
G
HPLDPA
-
TTM
G
T
L
I
D
S
AH
A
D
S
V
HTF
I
RE
G
EGK
G
-
QL
L
LD
G
R
--
N--A
G
--
-
-
L
AA
AIG
PT
I
FVDVDPNAS
L
SR
EE
I
FGPVL
V
V
TRFTSE
E
Q
A
L
QL
ANDSQYGL
G
A
A
V
W
T
R
DL
SR
A
H
R
M
S
RR
LK
A
G
SV
F
VN
NYNDGDMTV
P
F
GG
Y
K
Q
SG
N
G
RDK
S
LHA
L
EK
F
TEL
K
T
I
W
I
S
L
EA
fig|566546.4.peg.1391
Escherichia coli W
MNFHHLAYWQDKA
L
S
LAI
E
NR
L
F
ING
EYTAAAEN
---
ETFETV
D
P
V
T
QAP
L
AKIAR
G
KSV
D
I
D
R
AV
S
AA
RGV
F
ERGD
W
SLSS
P
AK
R
KAV
L
N
K
LA
D
L
M
E
AHAE
E
L
A
L
LE
TL
D
T
GK
PIRHSLRD
D
I
PGAARAIR
W
Y
A
E
AIDKVY
G
EVATTS
---
---SHELAMIV
R
E
P
V
GV
I
A
A
I
V
PWNFP
LL
L
TC
WK
LG
PALAAGN
S
VV
L
KPSE
K
S
PL
S
A
I
RL
A
G
L
AK
EAG
L
P
D
GV
L
NVV
T
G
F
G
HEA
G
QA
L
S
R
H
N
D
I
DA
IA
F
TGS
TR
TGK
Q
L
LKD
A
G
E
S
N
M
KRV
W
LE
A
GGKS
A
N
IV
FA
D
CP
D
-----
L
Q
K
A
ASATAAGIFY
N
Q
GQVC
IAGT
R
L
LLEESIA
D
E
F
LALLKQQAQNW
Q
P
G
HPLDPA
-
TTM
G
T
L
I
D
S
AH
A
D
S
V
HTF
I
RE
G
EGK
G
-
QL
L
LD
G
R
--
N--A
G
--
-
-
L
AA
AIG
PT
I
FVDVDPNAS
L
SR
EE
I
FGPVL
V
V
TRFTSE
E
Q
A
L
QL
ANDSQYGL
G
A
A
V
W
T
R
DL
SR
A
H
R
M
S
RR
LK
A
G
SV
F
VN
NYNDGDMTV
P
F
GG
Y
K
Q
SG
N
G
RDK
S
LHA
L
EK
F
TEL
K
T
I
W
I
S
L
EA
fig|340184.3.peg.234
Escherichia coli B7A
MNFHHLAYWQDKA
L
S
LAI
E
TR
L
F
ING
EYTAAAEN
---
ETFETV
D
P
V
T
QAP
L
AKIAR
G
KSV
D
I
D
R
AV
S
AA
RGV
F
ERGD
W
SLSS
P
AK
R
KAV
L
N
K
LA
D
L
M
E
AHAE
E
L
A
L
LE
TL
D
T
GK
PIRHSLRD
D
I
PGAARAIR
W
Y
A
E
AIDKVY
G
EVATTS
---
---SHELAMIV
R
E
P
V
GV
I
A
A
I
V
PWNFP
LL
L
TC
WK
LG
PALAAGN
S
VV
L
KPSE
K
S
PL
S
A
I
RL
A
G
L
AK
EAG
L
P
D
GV
L
NVV
T
G
F
G
HEA
G
QA
L
S
R
H
D
D
I
DA
IA
F
TGS
TR
TGK
Q
L
LKD
A
G
D
S
N
M
KRV
W
LE
A
GGKS
A
N
IV
FA
D
CP
D
-----
L
Q
K
A
ASATAAGIFY
N
Q
GQVC
IAGT
R
L
LLEESIA
D
E
F
LALLKQQAQNW
Q
P
G
HPLDPA
-
TTM
G
T
L
I
D
S
AH
A
D
S
V
HGF
I
RE
G
EGK
G
-
QL
L
LD
G
R
--
N--A
K
--
-
-
L
AA
AIG
PT
I
FVDVDPNAS
L
SR
EE
I
FGPVL
V
V
TRFTSE
DQ
A
L
QL
ANDSQYGL
G
A
A
V
W
T
R
DL
SR
A
H
R
M
S
RR
LK
A
G
SV
F
VN
NYNDGDMTV
P
F
GG
Y
K
Q
SG
N
G
RDK
S
LHA
L
EK
F
TEL
K
T
I
W
I
S
L
EA
fig|340184.6.peg.241
Escherichia coli B7A
MNFHHLAYWQDKA
L
S
LAI
E
TR
L
F
ING
EYTAAAEN
---
ETFETV
D
P
V
T
QAP
L
AKIAR
G
KSV
D
I
D
R
AV
S
AA
RGV
F
ERGD
W
SLSS
P
AK
R
KAV
L
N
K
LA
D
L
M
E
AHAE
E
L
A
L
LE
TL
D
T
GK
PIRHSLRD
D
I
PGAARAIR
W
Y
A
E
AIDKVY
G
EVATTS
---
---SHELAMIV
R
E
P
V
GV
I
A
A
I
V
PWNFP
LL
L
TC
WK
LG
PALAAGN
S
VV
L
KPSE
K
S
PL
S
A
I
RL
A
G
L
AK
EAG
L
P
D
GV
L
NVV
T
G
F
G
HEA
G
QA
L
S
R
H
D
D
I
DA
IA
F
TGS
TR
TGK
Q
L
LKD
A
G
D
S
N
M
KRV
W
LE
A
GGKS
A
N
IV
FA
D
CP
D
-----
L
Q
K
A
ASATAAGIFY
N
Q
GQVC
IAGT
R
L
LLEESIA
D
E
F
LALLKQQAQNW
Q
P
G
HPLDPA
-
TTM
G
T
L
I
D
S
AH
A
D
S
V
HGF
I
RE
G
EGK
G
-
QL
L
LD
G
R
--
N--A
K
--
-
-
L
AA
AIG
PT
I
FVDVDPNAS
L
SR
EE
I
FGPVL
V
V
TRFTSE
DQ
A
L
QL
ANDSQYGL
G
A
A
V
W
T
R
DL
SR
A
H
R
M
S
RR
LK
A
G
SV
F
VN
NYNDGDMTV
P
F
GG
Y
K
Q
SG
N
G
RDK
S
LHA
L
EK
F
TEL
K
T
I
W
I
S
L
EA
fig|562.375.peg.4206
Escherichia coli EC4100B
MNFHHLAYWQDKA
L
S
LAI
E
TR
L
F
ING
EYTAAAEN
---
ETFETV
D
P
V
T
QAP
L
AKIAR
G
KSV
D
I
D
R
AV
S
AA
RGV
F
ERGD
W
SLSS
P
AK
R
KAV
L
N
K
LA
D
L
M
E
AHAE
E
L
A
L
LE
TL
D
T
GK
PIRHSLRD
D
I
PGAARAIR
W
Y
A
E
AIDKVY
G
EVATTS
---
---SHELAMIV
R
E
P
V
GV
I
A
A
I
V
PWNFP
LL
L
TC
WK
LG
PALAAGN
S
VV
L
KPSE
K
S
PL
S
A
I
RL
A
G
L
AK
EAG
L
P
D
GV
L
NVV
T
G
F
G
HEA
G
QA
L
S
R
H
D
D
I
DA
IA
F
TGS
TR
TGK
Q
L
LKD
A
G
D
S
N
M
KRV
W
LE
A
GGKS
A
N
IV
FA
D
CP
D
-----
L
Q
K
A
ASATAAGIFY
N
Q
GQVC
IAGT
R
L
LLEESIA
D
E
F
LALLKQQAQNW
Q
P
G
HPLDPA
-
TTM
G
T
L
I
D
S
AH
A
D
S
V
HGF
I
RE
G
EGK
G
-
QL
L
LD
G
R
--
N--A
K
--
-
-
L
AA
AIG
PT
I
FVDVDPNAS
L
SR
EE
I
FGPVL
V
V
TRFTSE
DQ
A
L
QL
ANDSQYGL
G
A
A
V
W
T
R
DL
SR
A
H
R
M
S
RR
LK
A
G
SV
F
VN
NYNDGDMTV
P
F
GG
Y
K
Q
SG
N
G
RDK
S
LHA
L
EK
F
TEL
K
T
I
W
I
S
L
EA
fig|679204.3.peg.3999
Escherichia coli MS 145-7
MNFHHLAYWQDKA
L
S
LAI
E
TR
L
F
ING
EYTAAAEN
---
ETFETV
D
P
V
T
QAP
L
AKIAR
G
KSV
D
I
D
R
AV
S
AA
RGV
F
ERGD
W
SLSS
P
AK
R
KAV
L
N
K
LA
D
L
M
E
AHAE
E
L
A
L
LE
TL
D
T
GK
PIRHSLRD
D
I
PGAARAIR
W
Y
A
E
AIDKVY
G
EVATTS
---
---SHELAMIV
R
E
P
V
GV
I
A
A
I
V
PWNFP
LL
L
TC
WK
LG
PALAAGN
S
VV
L
KPSE
K
S
PL
S
A
I
RL
A
G
L
AK
EAG
L
P
D
GV
L
NVV
T
G
F
G
HEA
G
QA
L
S
R
H
D
D
I
DA
IA
F
TGS
TR
TGK
Q
L
LKD
A
G
D
S
N
M
KRV
W
LE
A
GGKS
A
N
IV
FA
D
CP
D
-----
L
Q
K
A
ASATAAGIFY
N
Q
GQVC
IAGT
R
L
LLEESIA
D
E
F
LALLKQQAQNW
Q
P
G
HPLDPA
-
TTM
G
T
L
I
D
S
AH
A
D
S
V
HGF
I
RE
G
EGK
G
-
QL
L
LD
G
R
--
N--A
K
--
-
-
L
AA
AIG
PT
I
FVDVDPNAS
L
SR
EE
I
FGPVL
V
V
TRFTSE
DQ
A
L
QL
ANDSQYGL
G
A
A
V
W
T
R
DL
SR
A
H
R
M
S
RR
LK
A
G
SV
F
VN
NYNDGDMTV
P
F
GG
Y
K
Q
SG
N
G
RDK
S
LHA
L
EK
F
TEL
K
T
I
W
I
S
L
EA
fig|670888.3.peg.1990
Escherichia coli 1827-70
MNFHHLAYWQDKA
L
S
LAI
E
NR
L
F
ING
EYTAAAEN
---
ETFETV
D
P
V
T
QAP
L
AKIAR
G
KSV
D
I
D
R
A
M
S
AA
RGV
F
ERGD
W
SLSS
P
AK
R
KAV
L
N
K
LA
D
L
M
E
AHAE
E
L
A
L
LE
TL
D
T
GK
PIRHSLRD
D
I
PGAARAIR
W
Y
A
E
AIDKVY
G
EVATTS
---
---SHELAMIV
R
E
P
V
GV
I
A
A
I
V
PWNFP
LL
L
TC
WK
LG
PALAAGN
S
V
I
L
KPSE
K
S
PL
S
A
I
RL
A
G
L
AK
EAG
L
P
D
GV
L
NVV
T
G
F
G
HEA
G
QA
L
S
R
H
N
D
I
DA
IA
F
TGS
TR
TGK
Q
L
LKD
A
G
D
S
N
M
KRV
W
LE
A
GGKS
A
N
IV
FA
D
CP
D
-----
L
Q
Q
A
ASATAAGIFY
N
Q
GQVC
IAGT
R
L
LLEESIA
D
E
F
LALLKQQAQNW
Q
P
G
HPLDPA
-
TTM
G
T
L
I
D
C
AH
A
D
S
V
HSF
I
RE
G
ESK
G
-
QL
L
LD
G
R
--
N--A
G
--
-
-
L
AA
AIG
PT
I
FVDVDPNAS
L
SR
EE
I
FGPVL
V
V
TRFTSE
E
Q
A
L
QL
ANDSQYGL
G
A
A
V
W
T
R
DL
SR
A
H
R
M
S
RR
LK
A
G
SV
F
VN
NYNDGDMTV
P
F
GG
Y
K
Q
SG
N
G
RDK
S
LHA
L
EK
F
TEL
K
T
I
W
I
S
L
EA
fig|344610.3.peg.1176
Escherichia coli 53638
MNFHHLAYWQDKA
L
S
LAI
E
NR
L
F
ING
EYTAAAEN
---
ETFETV
D
P
V
T
QAP
L
AKIAR
G
KSV
D
I
D
R
A
M
S
AA
RGV
F
ERGD
W
SLSS
P
AK
R
KAV
L
N
K
LA
D
L
M
E
AHAE
E
L
A
L
LE
TL
D
T
GK
PIRHSLRD
D
I
PGAARAIR
W
Y
A
E
AIDKVY
G
EVATTS
---
---SHELAMIV
R
E
P
V
GV
I
A
A
I
V
PWNFP
LL
L
TC
WK
LG
PALAAGN
S
V
I
L
KPSE
K
S
PL
S
A
I
RL
A
G
L
AK
EAG
L
P
D
GV
L
NVV
T
G
F
G
HEA
G
QA
L
S
R
H
N
D
I
DA
IA
F
TGS
TR
TGK
Q
L
LKD
A
G
D
S
N
M
KRV
W
LE
A
GGKS
A
N
IV
FA
D
CP
D
-----
L
Q
Q
A
ASATAAGIFY
N
Q
GQVC
IAGT
R
L
LLEESIA
D
E
F
LALLKQQAQNW
Q
P
G
HPLDPA
-
TTM
G
T
L
I
D
C
AH
A
D
S
V
HSF
I
RE
G
ESK
G
-
QL
L
LD
G
R
--
N--A
G
--
-
-
L
AA
AIG
PT
I
FVDVDPNAS
L
SR
EE
I
FGPVL
V
V
TRFTSE
E
Q
A
L
QL
ANDSQYGL
G
A
A
V
W
T
R
DL
SR
A
H
R
M
S
RR
LK
A
G
SV
F
VN
NYNDGDMTV
P
F
GG
Y
K
Q
SG
N
G
RDK
S
LHA
L
EK
F
TEL
K
T
I
W
I
S
L
EA
fig|344610.7.peg.4982
Escherichia coli 53638
MNFHHLAYWQDKA
L
S
LAI
E
NR
L
F
ING
EYTAAAEN
---
ETFETV
D
P
V
T
QAP
L
AKIAR
G
KSV
D
I
D
R
A
M
S
AA
RGV
F
ERGD
W
SLSS
P
AK
R
KAV
L
N
K
LA
D
L
M
E
AHAE
E
L
A
L
LE
TL
D
T
GK
PIRHSLRD
D
I
PGAARAIR
W
Y
A
E
AIDKVY
G
EVATTS
---
---SHELAMIV
R
E
P
V
GV
I
A
A
I
V
PWNFP
LL
L
TC
WK
LG
PALAAGN
S
V
I
L
KPSE
K
S
PL
S
A
I
RL
A
G
L
AK
EAG
L
P
D
GV
L
NVV
T
G
F
G
HEA
G
QA
L
S
R
H
N
D
I
DA
IA
F
TGS
TR
TGK
Q
L
LKD
A
G
D
S
N
M
KRV
W
LE
A
GGKS
A
N
IV
FA
D
CP
D
-----
L
Q
Q
A
ASATAAGIFY
N
Q
GQVC
IAGT
R
L
LLEESIA
D
E
F
LALLKQQAQNW
Q
P
G
HPLDPA
-
TTM
G
T
L
I
D
C
AH
A
D
S
V
HSF
I
RE
G
ESK
G
-
QL
L
LD
G
R
--
N--A
G
--
-
-
L
AA
AIG
PT
I
FVDVDPNAS
L
SR
EE
I
FGPVL
V
V
TRFTSE
E
Q
A
L
QL
ANDSQYGL
G
A
A
V
W
T
R
DL
SR
A
H
R
M
S
RR
LK
A
G
SV
F
VN
NYNDGDMTV
P
F
GG
Y
K
Q
SG
N
G
RDK
S
LHA
L
EK
F
TEL
K
T
I
W
I
S
L
EA
fig|413997.3.peg.1347
Escherichia coli B str. REL606
MNFHHLAYWQDKA
L
S
LAI
E
NR
L
F
ING
EYTAAAEN
---
ETFETV
D
P
V
T
QAP
L
AKIAR
G
KSV
D
I
D
R
A
M
S
AA
RGV
F
ERGD
W
SLSS
P
AK
R
KAV
L
N
K
LA
D
L
M
E
AHAE
E
L
A
L
LE
TL
D
T
GK
PIRHSLRD
D
I
PGAARAIR
W
Y
A
E
AIDKVY
G
EVATTS
---
---SHELAMIV
R
E
P
V
GV
I
A
A
I
V
PWNFP
LL
L
TC
WK
LG
PALAAGN
S
V
I
L
KPSE
K
S
PL
S
A
I
RL
A
G
L
AK
EAG
L
P
D
GV
L
NVV
T
G
F
G
HEA
G
QA
L
S
R
H
N
D
I
DA
IA
F
TGS
TR
TGK
Q
L
LKD
A
G
D
S
N
M
KRV
W
LE
A
GGKS
A
N
IV
FA
D
CP
D
-----
L
Q
Q
A
ASATAAGIFY
N
Q
GQVC
IAGT
R
L
LLEESIA
D
E
F
LALLKQQAQNW
Q
P
G
HPLDPA
-
TTM
G
T
L
I
D
C
AH
A
D
S
V
HSF
I
RE
G
ESK
G
-
QL
L
LD
G
R
--
N--A
G
--
-
-
L
AA
AIG
PT
I
FVDVDPNAS
L
SR
EE
I
FGPVL
V
V
TRFTSE
E
Q
A
L
QL
ANDSQYGL
G
A
A
V
W
T
R
DL
SR
A
H
R
M
S
RR
LK
A
G
SV
F
VN
NYNDGDMTV
P
F
GG
Y
K
Q
SG
N
G
RDK
S
LHA
L
EK
F
TEL
K
T
I
W
I
S
L
EA
fig|511693.5.peg.1381
Escherichia coli BL21
MNFHHLAYWQDKA
L
S
LAI
E
NR
L
F
ING
EYTAAAEN
---
ETFETV
D
P
V
T
QAP
L
AKIAR
G
KSV
D
I
D
R
A
M
S
AA
RGV
F
ERGD
W
SLSS
P
AK
R
KAV
L
N
K
LA
D
L
M
E
AHAE
E
L
A
L
LE
TL
D
T
GK
PIRHSLRD
D
I
PGAARAIR
W
Y
A
E
AIDKVY
G
EVATTS
---
---SHELAMIV
R
E
P
V
GV
I
A
A
I
V
PWNFP
LL
L
TC
WK
LG
PALAAGN
S
V
I
L
KPSE
K
S
PL
S
A
I
RL
A
G
L
AK
EAG
L
P
D
GV
L
NVV
T
G
F
G
HEA
G
QA
L
S
R
H
N
D
I
DA
IA
F
TGS
TR
TGK
Q
L
LKD
A
G
D
S
N
M
KRV
W
LE
A
GGKS
A
N
IV
FA
D
CP
D
-----
L
Q
Q
A
ASATAAGIFY
N
Q
GQVC
IAGT
R
L
LLEESIA
D
E
F
LALLKQQAQNW
Q
P
G
HPLDPA
-
TTM
G
T
L
I
D
C
AH
A
D
S
V
HSF
I
RE
G
ESK
G
-
QL
L
LD
G
R
--
N--A
G
--
-
-
L
AA
AIG
PT
I
FVDVDPNAS
L
SR
EE
I
FGPVL
V
V
TRFTSE
E
Q
A
L
QL
ANDSQYGL
G
A
A
V
W
T
R
DL
SR
A
H
R
M
S
RR
LK
A
G
SV
F
VN
NYNDGDMTV
P
F
GG
Y
K
Q
SG
N
G
RDK
S
LHA
L
EK
F
TEL
K
T
I
W
I
S
L
EA
fig|469008.4.peg.2389
Escherichia coli BL21(DE3)
MNFHHLAYWQDKA
L
S
LAI
E
NR
L
F
ING
EYTAAAEN
---
ETFETV
D
P
V
T
QAP
L
AKIAR
G
KSV
D
I
D
R
A
M
S
AA
RGV
F
ERGD
W
SLSS
P
AK
R
KAV
L
N
K
LA
D
L
M
E
AHAE
E
L
A
L
LE
TL
D
T
GK
PIRHSLRD
D
I
PGAARAIR
W
Y
A
E
AIDKVY
G
EVATTS
---
---SHELAMIV
R
E
P
V
GV
I
A
A
I
V
PWNFP
LL
L
TC
WK
LG
PALAAGN
S
V
I
L
KPSE
K
S
PL
S
A
I
RL
A
G
L
AK
EAG
L
P
D
GV
L
NVV
T
G
F
G
HEA
G
QA
L
S
R
H
N
D
I
DA
IA
F
TGS
TR
TGK
Q
L
LKD
A
G
D
S
N
M
KRV
W
LE
A
GGKS
A
N
IV
FA
D
CP
D
-----
L
Q
Q
A
ASATAAGIFY
N
Q
GQVC
IAGT
R
L
LLEESIA
D
E
F
LALLKQQAQNW
Q
P
G
HPLDPA
-
TTM
G
T
L
I
D
C
AH
A
D
S
V
HSF
I
RE
G
ESK
G
-
QL
L
LD
G
R
--
N--A
G
--
-
-
L
AA
AIG
PT
I
FVDVDPNAS
L
SR
EE
I
FGPVL
V
V
TRFTSE
E
Q
A
L
QL
ANDSQYGL
G
A
A
V
W
T
R
DL
SR
A
H
R
M
S
RR
LK
A
G
SV
F
VN
NYNDGDMTV
P
F
GG
Y
K
Q
SG
N
G
RDK
S
LHA
L
EK
F
TEL
K
T
I
W
I
S
L
EA
fig|595496.3.peg.1241
Escherichia coli BW2952
MNFHHLAYWQDKA
L
S
LAI
E
NR
L
F
ING
EYTAAAEN
---
ETFETV
D
P
V
T
QAP
L
AKIAR
G
KSV
D
I
D
R
A
M
S
AA
RGV
F
ERGD
W
SLSS
P
AK
R
KAV
L
N
K
LA
D
L
M
E
AHAE
E
L
A
L
LE
TL
D
T
GK
PIRHSLRD
D
I
PGAARAIR
W
Y
A
E
AIDKVY
G
EVATTS
---
---SHELAMIV
R
E
P
V
GV
I
A
A
I
V
PWNFP
LL
L
TC
WK
LG
PALAAGN
S
V
I
L
KPSE
K
S
PL
S
A
I
RL
A
G
L
AK
EAG
L
P
D
GV
L
NVV
T
G
F
G
HEA
G
QA
L
S
R
H
N
D
I
DA
IA
F
TGS
TR
TGK
Q
L
LKD
A
G
D
S
N
M
KRV
W
LE
A
GGKS
A
N
IV
FA
D
CP
D
-----
L
Q
Q
A
ASATAAGIFY
N
Q
GQVC
IAGT
R
L
LLEESIA
D
E
F
LALLKQQAQNW
Q
P
G
HPLDPA
-
TTM
G
T
L
I
D
C
AH
A
D
S
V
HSF
I
RE
G
ESK
G
-
QL
L
LD
G
R
--
N--A
G
--
-
-
L
AA
AIG
PT
I
FVDVDPNAS
L
SR
EE
I
FGPVL
V
V
TRFTSE
E
Q
A
L
QL
ANDSQYGL
G
A
A
V
W
T
R
DL
SR
A
H
R
M
S
RR
LK
A
G
SV
F
VN
NYNDGDMTV
P
F
GG
Y
K
Q
SG
N
G
RDK
S
LHA
L
EK
F
TEL
K
T
I
W
I
S
L
EA
fig|536056.3.peg.2468
Escherichia coli DH1
MNFHHLAYWQDKA
L
S
LAI
E
NR
L
F
ING
EYTAAAEN
---
ETFETV
D
P
V
T
QAP
L
AKIAR
G
KSV
D
I
D
R
A
M
S
AA
RGV
F
ERGD
W
SLSS
P
AK
R
KAV
L
N
K
LA
D
L
M
E
AHAE
E
L
A
L
LE
TL
D
T
GK
PIRHSLRD
D
I
PGAARAIR
W
Y
A
E
AIDKVY
G
EVATTS
---
---SHELAMIV
R
E
P
V
GV
I
A
A
I
V
PWNFP
LL
L
TC
WK
LG
PALAAGN
S
V
I
L
KPSE
K
S
PL
S
A
I
RL
A
G
L
AK
EAG
L
P
D
GV
L
NVV
T
G
F
G
HEA
G
QA
L
S
R
H
N
D
I
DA
IA
F
TGS
TR
TGK
Q
L
LKD
A
G
D
S
N
M
KRV
W
LE
A
GGKS
A
N
IV
FA
D
CP
D
-----
L
Q
Q
A
ASATAAGIFY
N
Q
GQVC
IAGT
R
L
LLEESIA
D
E
F
LALLKQQAQNW
Q
P
G
HPLDPA
-
TTM
G
T
L
I
D
C
AH
A
D
S
V
HSF
I
RE
G
ESK
G
-
QL
L
LD
G
R
--
N--A
G
--
-
-
L
AA
AIG
PT
I
FVDVDPNAS
L
SR
EE
I
FGPVL
V
V
TRFTSE
E
Q
A
L
QL
ANDSQYGL
G
A
A
V
W
T
R
DL
SR
A
H
R
M
S
RR
LK
A
G
SV
F
VN
NYNDGDMTV
P
F
GG
Y
K
Q
SG
N
G
RDK
S
LHA
L
EK
F
TEL
K
T
I
W
I
S
L
EA
fig|316401.4.peg.1619
Escherichia coli ETEC H10407
MNFHHLAYWQDKA
L
S
LAI
E
NR
L
F
ING
EYTAAAEN
---
ETFETV
D
P
V
T
QAP
L
AKIAR
G
KSV
D
I
D
R
A
M
S
AA
RGV
F
ERGD
W
SLSS
P
AK
R
KAV
L
N
K
LA
D
L
M
E
AHAE
E
L
A
L
LE
TL
D
T
GK
PIRHSLRD
D
I
PGAARAIR
W
Y
A
E
AIDKVY
G
EVATTS
---
---SHELAMIV
R
E
P
V
GV
I
A
A
I
V
PWNFP
LL
L
TC
WK
LG
PALAAGN
S
V
I
L
KPSE
K
S
PL
S
A
I
RL
A
G
L
AK
EAG
L
P
D
GV
L
NVV
T
G
F
G
HEA
G
QA
L
S
R
H
N
D
I
DA
IA
F
TGS
TR
TGK
Q
L
LKD
A
G
D
S
N
M
KRV
W
LE
A
GGKS
A
N
IV
FA
D
CP
D
-----
L
Q
Q
A
ASATAAGIFY
N
Q
GQVC
IAGT
R
L
LLEESIA
D
E
F
LALLKQQAQNW
Q
P
G
HPLDPA
-
TTM
G
T
L
I
D
C
AH
A
D
S
V
HSF
I
RE
G
ESK
G
-
QL
L
LD
G
R
--
N--A
G
--
-
-
L
AA
AIG
PT
I
FVDVDPNAS
L
SR
EE
I
FGPVL
V
V
TRFTSE
E
Q
A
L
QL
ANDSQYGL
G
A
A
V
W
T
R
DL
SR
A
H
R
M
S
RR
LK
A
G
SV
F
VN
NYNDGDMTV
P
F
GG
Y
K
Q
SG
N
G
RDK
S
LHA
L
EK
F
TEL
K
T
I
W
I
S
L
EA
fig|331112.3.peg.1325
Escherichia coli HS
MNFHHLAYWQDKA
L
S
LAI
E
NR
L
F
ING
EYTAAAEN
---
ETFETV
D
P
V
T
QAP
L
AKIAR
G
KSV
D
I
D
R
A
M
S
AA
RGV
F
ERGD
W
SLSS
P
AK
R
KAV
L
N
K
LA
D
L
M
E
AHAE
E
L
A
L
LE
TL
D
T
GK
PIRHSLRD
D
I
PGAARAIR
W
Y
A
E
AIDKVY
G
EVATTS
---
---SHELAMIV
R
E
P
V
GV
I
A
A
I
V
PWNFP
LL
L
TC
WK
LG
PALAAGN
S
V
I
L
KPSE
K
S
PL
S
A
I
RL
A
G
L
AK
EAG
L
P
D
GV
L
NVV
T
G
F
G
HEA
G
QA
L
S
R
H
N
D
I
DA
IA
F
TGS
TR
TGK
Q
L
LKD
A
G
D
S
N
M
KRV
W
LE
A
GGKS
A
N
IV
FA
D
CP
D
-----
L
Q
Q
A
ASATAAGIFY
N
Q
GQVC
IAGT
R
L
LLEESIA
D
E
F
LALLKQQAQNW
Q
P
G
HPLDPA
-
TTM
G
T
L
I
D
C
AH
A
D
S
V
HSF
I
RE
G
ESK
G
-
QL
L
LD
G
R
--
N--A
G
--
-
-
L
AA
AIG
PT
I
FVDVDPNAS
L
SR
EE
I
FGPVL
V
V
TRFTSE
E
Q
A
L
QL
ANDSQYGL
G
A
A
V
W
T
R
DL
SR
A
H
R
M
S
RR
LK
A
G
SV
F
VN
NYNDGDMTV
P
F
GG
Y
K
Q
SG
N
G
RDK
S
LHA
L
EK
F
TEL
K
T
I
W
I
S
L
EA
fig|331112.6.peg.1379
Escherichia coli HS
MNFHHLAYWQDKA
L
S
LAI
E
NR
L
F
ING
EYTAAAEN
---
ETFETV
D
P
V
T
QAP
L
AKIAR
G
KSV
D
I
D
R
A
M
S
AA
RGV
F
ERGD
W
SLSS
P
AK
R
KAV
L
N
K
LA
D
L
M
E
AHAE
E
L
A
L
LE
TL
D
T
GK
PIRHSLRD
D
I
PGAARAIR
W
Y
A
E
AIDKVY
G
EVATTS
---
---SHELAMIV
R
E
P
V
GV
I
A
A
I
V
PWNFP
LL
L
TC
WK
LG
PALAAGN
S
V
I
L
KPSE
K
S
PL
S
A
I
RL
A
G
L
AK
EAG
L
P
D
GV
L
NVV
T
G
F
G
HEA
G
QA
L
S
R
H
N
D
I
DA
IA
F
TGS
TR
TGK
Q
L
LKD
A
G
D
S
N
M
KRV
W
LE
A
GGKS
A
N
IV
FA
D
CP
D
-----
L
Q
Q
A
ASATAAGIFY
N
Q
GQVC
IAGT
R
L
LLEESIA
D
E
F
LALLKQQAQNW
Q
P
G
HPLDPA
-
TTM
G
T
L
I
D
C
AH
A
D
S
V
HSF
I
RE
G
ESK
G
-
QL
L
LD
G
R
--
N--A
G
--
-
-
L
AA
AIG
PT
I
FVDVDPNAS
L
SR
EE
I
FGPVL
V
V
TRFTSE
E
Q
A
L
QL
ANDSQYGL
G
A
A
V
W
T
R
DL
SR
A
H
R
M
S
RR
LK
A
G
SV
F
VN
NYNDGDMTV
P
F
GG
Y
K
Q
SG
N
G
RDK
S
LHA
L
EK
F
TEL
K
T
I
W
I
S
L
EA
fig|83333.1.peg.1288
Escherichia coli K12
MNFHHLAYWQDKA
L
S
LAI
E
NR
L
F
ING
EYTAAAEN
---
ETFETV
D
P
V
T
QAP
L
AKIAR
G
KSV
D
I
D
R
A
M
S
AA
RGV
F
ERGD
W
SLSS
P
AK
R
KAV
L
N
K
LA
D
L
M
E
AHAE
E
L
A
L
LE
TL
D
T
GK
PIRHSLRD
D
I
PGAARAIR
W
Y
A
E
AIDKVY
G
EVATTS
---
---SHELAMIV
R
E
P
V
GV
I
A
A
I
V
PWNFP
LL
L
TC
WK
LG
PALAAGN
S
V
I
L
KPSE
K
S
PL
S
A
I
RL
A
G
L
AK
EAG
L
P
D
GV
L
NVV
T
G
F
G
HEA
G
QA
L
S
R
H
N
D
I
DA
IA
F
TGS
TR
TGK
Q
L
LKD
A
G
D
S
N
M
KRV
W
LE
A
GGKS
A
N
IV
FA
D
CP
D
-----
L
Q
Q
A
ASATAAGIFY
N
Q
GQVC
IAGT
R
L
LLEESIA
D
E
F
LALLKQQAQNW
Q
P
G
HPLDPA
-
TTM
G
T
L
I
D
C
AH
A
D
S
V
HSF
I
RE
G
ESK
G
-
QL
L
LD
G
R
--
N--A
G
--
-
-
L
AA
AIG
PT
I
FVDVDPNAS
L
SR
EE
I
FGPVL
V
V
TRFTSE
E
Q
A
L
QL
ANDSQYGL
G
A
A
V
W
T
R
DL
SR
A
H
R
M
S
RR
LK
A
G
SV
F
VN
NYNDGDMTV
P
F
GG
Y
K
Q
SG
N
G
RDK
S
LHA
L
EK
F
TEL
K
T
I
W
I
S
L
EA
fig|749538.3.peg.1807
Escherichia coli MS 116-1
MNFHHLAYWQDKA
L
S
LAI
E
NR
L
F
ING
EYTAAAEN
---
ETFETV
D
P
V
T
QAP
L
AKIAR
G
KSV
D
I
D
R
A
M
S
AA
RGV
F
ERGD
W
SLSS
P
AK
R
KAV
L
N
K
LA
D
L
M
E
AHAE
E
L
A
L
LE
TL
D
T
GK
PIRHSLRD
D
I
PGAARAIR
W
Y
A
E
AIDKVY
G
EVATTS
---
---SHELAMIV
R
E
P
V
GV
I
A
A
I
V
PWNFP
LL
L
TC
WK
LG
PALAAGN
S
V
I
L
KPSE
K
S
PL
S
A
I
RL
A
G
L
AK
EAG
L
P
D
GV
L
NVV
T
G
F
G
HEA
G
QA
L
S
R
H
N
D
I
DA
IA
F
TGS
TR
TGK
Q
L
LKD
A
G
D
S
N
M
KRV
W
LE
A
GGKS
A
N
IV
FA
D
CP
D
-----
L
Q
Q
A
ASATAAGIFY
N
Q
GQVC
IAGT
R
L
LLEESIA
D
E
F
LALLKQQAQNW
Q
P
G
HPLDPA
-
TTM
G
T
L
I
D
C
AH
A
D
S
V
HSF
I
RE
G
ESK
G
-
QL
L
LD
G
R
--
N--A
G
--
-
-
L
AA
AIG
PT
I
FVDVDPNAS
L
SR
EE
I
FGPVL
V
V
TRFTSE
E
Q
A
L
QL
ANDSQYGL
G
A
A
V
W
T
R
DL
SR
A
H
R
M
S
RR
LK
A
G
SV
F
VN
NYNDGDMTV
P
F
GG
Y
K
Q
SG
N
G
RDK
S
LHA
L
EK
F
TEL
K
T
I
W
I
S
L
EA
fig|749544.3.peg.471
Escherichia coli MS 175-1
MNFHHLAYWQDKA
L
S
LAI
E
NR
L
F
ING
EYTAAAEN
---
ETFETV
D
P
V
T
QAP
L
AKIAR
G
KSV
D
I
D
R
A
M
S
AA
RGV
F
ERGD
W
SLSS
P
AK
R
KAV
L
N
K
LA
D
L
M
E
AHAE
E
L
A
L
LE
TL
D
T
GK
PIRHSLRD
D
I
PGAARAIR
W
Y
A
E
AIDKVY
G
EVATTS
---
---SHELAMIV
R
E
P
V
GV
I
A
A
I
V
PWNFP
LL
L
TC
WK
LG
PALAAGN
S
V
I
L
KPSE
K
S
PL
S
A
I
RL
A
G
L
AK
EAG
L
P
D
GV
L
NVV
T
G
F
G
HEA
G
QA
L
S
R
H
N
D
I
DA
IA
F
TGS
TR
TGK
Q
L
LKD
A
G
D
S
N
M
KRV
W
LE
A
GGKS
A
N
IV
FA
D
CP
D
-----
L
Q
Q
A
ASATAAGIFY
N
Q
GQVC
IAGT
R
L
LLEESIA
D
E
F
LALLKQQAQNW
Q
P
G
HPLDPA
-
TTM
G
T
L
I
D
C
AH
A
D
S
V
HSF
I
RE
G
ESK
G
-
QL
L
LD
G
R
--
N--A
G
--
-
-
L
AA
AIG
PT
I
FVDVDPNAS
L
SR
EE
I
FGPVL
V
V
TRFTSE
E
Q
A
L
QL
ANDSQYGL
G
A
A
V
W
T
R
DL
SR
A
H
R
M
S
RR
LK
A
G
SV
F
VN
NYNDGDMTV
P
F
GG
Y
K
Q
SG
N
G
RDK
S
LHA
L
EK
F
TEL
K
T
I
W
I
S
L
EA
fig|749547.3.peg.180
Escherichia coli MS 187-1
MNFHHLAYWQDKA
L
S
LAI
E
NR
L
F
ING
EYTAAAEN
---
ETFETV
D
P
V
T
QAP
L
AKIAR
G
KSV
D
I
D
R
A
M
S
AA
RGV
F
ERGD
W
SLSS
P
AK
R
KAV
L
N
K
LA
D
L
M
E
AHAE
E
L
A
L
LE
TL
D
T
GK
PIRHSLRD
D
I
PGAARAIR
W
Y
A
E
AIDKVY
G
EVATTS
---
---SHELAMIV
R
E
P
V
GV
I
A
A
I
V
PWNFP
LL
L
TC
WK
LG
PALAAGN
S
V
I
L
KPSE
K
S
PL
S
A
I
RL
A
G
L
AK
EAG
L
P
D
GV
L
NVV
T
G
F
G
HEA
G
QA
L
S
R
H
N
D
I
DA
IA
F
TGS
TR
TGK
Q
L
LKD
A
G
D
S
N
M
KRV
W
LE
A
GGKS
A
N
IV
FA
D
CP
D
-----
L
Q
Q
A
ASATAAGIFY
N
Q
GQVC
IAGT
R
L
LLEESIA
D
E
F
LALLKQQAQNW
Q
P
G
HPLDPA
-
TTM
G
T
L
I
D
C
AH
A
D
S
V
HSF
I
RE
G
ESK
G
-
QL
L
LD
G
R
--
N--A
G
--
-
-
L
AA
AIG
PT
I
FVDVDPNAS
L
SR
EE
I
FGPVL
V
V
TRFTSE
E
Q
A
L
QL
ANDSQYGL
G
A
A
V
W
T
R
DL
SR
A
H
R
M
S
RR
LK
A
G
SV
F
VN
NYNDGDMTV
P
F
GG
Y
K
Q
SG
N
G
RDK
S
LHA
L
EK
F
TEL
K
T
I
W
I
S
L
EA
fig|749548.3.peg.1559
Escherichia coli MS 196-1
MNFHHLAYWQDKA
L
S
LAI
E
NR
L
F
ING
EYTAAAEN
---
ETFETV
D
P
V
T
QAP
L
AKIAR
G
KSV
D
I
D
R
A
M
S
AA
RGV
F
ERGD
W
SLSS
P
AK
R
KAV
L
N
K
LA
D
L
M
E
AHAE
E
L
A
L
LE
TL
D
T
GK
PIRHSLRD
D
I
PGAARAIR
W
Y
A
E
AIDKVY
G
EVATTS
---
---SHELAMIV
R
E
P
V
GV
I
A
A
I
V
PWNFP
LL
L
TC
WK
LG
PALAAGN
S
V
I
L
KPSE
K
S
PL
S
A
I
RL
A
G
L
AK
EAG
L
P
D
GV
L
NVV
T
G
F
G
HEA
G
QA
L
S
R
H
N
D
I
DA
IA
F
TGS
TR
TGK
Q
L
LKD
A
G
D
S
N
M
KRV
W
LE
A
GGKS
A
N
IV
FA
D
CP
D
-----
L
Q
Q
A
ASATAAGIFY
N
Q
GQVC
IAGT
R
L
LLEESIA
D
E
F
LALLKQQAQNW
Q
P
G
HPLDPA
-
TTM
G
T
L
I
D
C
AH
A
D
S
V
HSF
I
RE
G
ESK
G
-
QL
L
LD
G
R
--
N--A
G
--
-
-
L
AA
AIG
PT
I
FVDVDPNAS
L
SR
EE
I
FGPVL
V
V
TRFTSE
E
Q
A
L
QL
ANDSQYGL
G
A
A
V
W
T
R
DL
SR
A
H
R
M
S
RR
LK
A
G
SV
F
VN
NYNDGDMTV
P
F
GG
Y
K
Q
SG
N
G
RDK
S
LHA
L
EK
F
TEL
K
T
I
W
I
S
L
EA
fig|316407.3.peg.1262
Escherichia coli W3110
MNFHHLAYWQDKA
L
S
LAI
E
NR
L
F
ING
EYTAAAEN
---
ETFETV
D
P
V
T
QAP
L
AKIAR
G
KSV
D
I
D
R
A
M
S
AA
RGV
F
ERGD
W
SLSS
P
AK
R
KAV
L
N
K
LA
D
L
M
E
AHAE
E
L
A
L
LE
TL
D
T
GK
PIRHSLRD
D
I
PGAARAIR
W
Y
A
E
AIDKVY
G
EVATTS
---
---SHELAMIV
R
E
P
V
GV
I
A
A
I
V
PWNFP
LL
L
TC
WK
LG
PALAAGN
S
V
I
L
KPSE
K
S
PL
S
A
I
RL
A
G
L
AK
EAG
L
P
D
GV
L
NVV
T
G
F
G
HEA
G
QA
L
S
R
H
N
D
I
DA
IA
F
TGS
TR
TGK
Q
L
LKD
A
G
D
S
N
M
KRV
W
LE
A
GGKS
A
N
IV
FA
D
CP
D
-----
L
Q
Q
A
ASATAAGIFY
N
Q
GQVC
IAGT
R
L
LLEESIA
D
E
F
LALLKQQAQNW
Q
P
G
HPLDPA
-
TTM
G
T
L
I
D
C
AH
A
D
S
V
HSF
I
RE
G
ESK
G
-
QL
L
LD
G
R
--
N--A
G
--
-
-
L
AA
AIG
PT
I
FVDVDPNAS
L
SR
EE
I
FGPVL
V
V
TRFTSE
E
Q
A
L
QL
ANDSQYGL
G
A
A
V
W
T
R
DL
SR
A
H
R
M
S
RR
LK
A
G
SV
F
VN
NYNDGDMTV
P
F
GG
Y
K
Q
SG
N
G
RDK
S
LHA
L
EK
F
TEL
K
T
I
W
I
S
L
EA
fig|316385.5.peg.1407
Escherichia coli str. K-12 substr. DH10B
MNFHHLAYWQDKA
L
S
LAI
E
NR
L
F
ING
EYTAAAEN
---
ETFETV
D
P
V
T
QAP
L
AKIAR
G
KSV
D
I
D
R
A
M
S
AA
RGV
F
ERGD
W
SLSS
P
AK
R
KAV
L
N
K
LA
D
L
M
E
AHAE
E
L
A
L
LE
TL
D
T
GK
PIRHSLRD
D
I
PGAARAIR
W
Y
A
E
AIDKVY
G
EVATTS
---
---SHELAMIV
R
E
P
V
GV
I
A
A
I
V
PWNFP
LL
L
TC
WK
LG
PALAAGN
S
V
I
L
KPSE
K
S
PL
S
A
I
RL
A
G
L
AK
EAG
L
P
D
GV
L
NVV
T
G
F
G
HEA
G
QA
L
S
R
H
N
D
I
DA
IA
F
TGS
TR
TGK
Q
L
LKD
A
G
D
S
N
M
KRV
W
LE
A
GGKS
A
N
IV
FA
D
CP
D
-----
L
Q
Q
A
ASATAAGIFY
N
Q
GQVC
IAGT
R
L
LLEESIA
D
E
F
LALLKQQAQNW
Q
P
G
HPLDPA
-
TTM
G
T
L
I
D
C
AH
A
D
S
V
HSF
I
RE
G
ESK
G
-
QL
L
LD
G
R
--
N--A
G
--
-
-
L
AA
AIG
PT
I
FVDVDPNAS
L
SR
EE
I
FGPVL
V
V
TRFTSE
E
Q
A
L
QL
ANDSQYGL
G
A
A
V
W
T
R
DL
SR
A
H
R
M
S
RR
LK
A
G
SV
F
VN
NYNDGDMTV
P
F
GG
Y
K
Q
SG
N
G
RDK
S
LHA
L
EK
F
TEL
K
T
I
W
I
S
L
EA
fig|316385.7.peg.1443
Escherichia coli str. K-12 substr. DH10B
MNFHHLAYWQDKA
L
S
LAI
E
NR
L
F
ING
EYTAAAEN
---
ETFETV
D
P
V
T
QAP
L
AKIAR
G
KSV
D
I
D
R
A
M
S
AA
RGV
F
ERGD
W
SLSS
P
AK
R
KAV
L
N
K
LA
D
L
M
E
AHAE
E
L
A
L
LE
TL
D
T
GK
PIRHSLRD
D
I
PGAARAIR
W
Y
A
E
AIDKVY
G
EVATTS
---
---SHELAMIV
R
E
P
V
GV
I
A
A
I
V
PWNFP
LL
L
TC
WK
LG
PALAAGN
S
V
I
L
KPSE
K
S
PL
S
A
I
RL
A
G
L
AK
EAG
L
P
D
GV
L
NVV
T
G
F
G
HEA
G
QA
L
S
R
H
N
D
I
DA
IA
F
TGS
TR
TGK
Q
L
LKD
A
G
D
S
N
M
KRV
W
LE
A
GGKS
A
N
IV
FA
D
CP
D
-----
L
Q
Q
A
ASATAAGIFY
N
Q
GQVC
IAGT
R
L
LLEESIA
D
E
F
LALLKQQAQNW
Q
P
G
HPLDPA
-
TTM
G
T
L
I
D
C
AH
A
D
S
V
HSF
I
RE
G
ESK
G
-
QL
L
LD
G
R
--
N--A
G
--
-
-
L
AA
AIG
PT
I
FVDVDPNAS
L
SR
EE
I
FGPVL
V
V
TRFTSE
E
Q
A
L
QL
ANDSQYGL
G
A
A
V
W
T
R
DL
SR
A
H
R
M
S
RR
LK
A
G
SV
F
VN
NYNDGDMTV
P
F
GG
Y
K
Q
SG
N
G
RDK
S
LHA
L
EK
F
TEL
K
T
I
W
I
S
L
EA
fig|511145.12.peg.1356
Escherichia coli str. K-12 substr. MG1655
MNFHHLAYWQDKA
L
S
LAI
E
NR
L
F
ING
EYTAAAEN
---
ETFETV
D
P
V
T
QAP
L
AKIAR
G
KSV
D
I
D
R
A
M
S
AA
RGV
F
ERGD
W
SLSS
P
AK
R
KAV
L
N
K
LA
D
L
M
E
AHAE
E
L
A
L
LE
TL
D
T
GK
PIRHSLRD
D
I
PGAARAIR
W
Y
A
E
AIDKVY
G
EVATTS
---
---SHELAMIV
R
E
P
V
GV
I
A
A
I
V
PWNFP
LL
L
TC
WK
LG
PALAAGN
S
V
I
L
KPSE
K
S
PL
S
A
I
RL
A
G
L
AK
EAG
L
P
D
GV
L
NVV
T
G
F
G
HEA
G
QA
L
S
R
H
N
D
I
DA
IA
F
TGS
TR
TGK
Q
L
LKD
A
G
D
S
N
M
KRV
W
LE
A
GGKS
A
N
IV
FA
D
CP
D
-----
L
Q
Q
A
ASATAAGIFY
N
Q
GQVC
IAGT
R
L
LLEESIA
D
E
F
LALLKQQAQNW
Q
P
G
HPLDPA
-
TTM
G
T
L
I
D
C
AH
A
D
S
V
HSF
I
RE
G
ESK
G
-
QL
L
LD
G
R
--
N--A
G
--
-
-
L
AA
AIG
PT
I
FVDVDPNAS
L
SR
EE
I
FGPVL
V
V
TRFTSE
E
Q
A
L
QL
ANDSQYGL
G
A
A
V
W
T
R
DL
SR
A
H
R
M
S
RR
LK
A
G
SV
F
VN
NYNDGDMTV
P
F
GG
Y
K
Q
SG
N
G
RDK
S
LHA
L
EK
F
TEL
K
T
I
W
I
S
L
EA
fig|511145.6.peg.1344
Escherichia coli str. K-12 substr. MG1655
MNFHHLAYWQDKA
L
S
LAI
E
NR
L
F
ING
EYTAAAEN
---
ETFETV
D
P
V
T
QAP
L
AKIAR
G
KSV
D
I
D
R
A
M
S
AA
RGV
F
ERGD
W
SLSS
P
AK
R
KAV
L
N
K
LA
D
L
M
E
AHAE
E
L
A
L
LE
TL
D
T
GK
PIRHSLRD
D
I
PGAARAIR
W
Y
A
E
AIDKVY
G
EVATTS
---
---SHELAMIV
R
E
P
V
GV
I
A
A
I
V
PWNFP
LL
L
TC
WK
LG
PALAAGN
S
V
I
L
KPSE
K
S
PL
S
A
I
RL
A
G
L
AK
EAG
L
P
D
GV
L
NVV
T
G
F
G
HEA
G
QA
L
S
R
H
N
D
I
DA
IA
F
TGS
TR
TGK
Q
L
LKD
A
G
D
S
N
M
KRV
W
LE
A
GGKS
A
N
IV
FA
D
CP
D
-----
L
Q
Q
A
ASATAAGIFY
N
Q
GQVC
IAGT
R
L
LLEESIA
D
E
F
LALLKQQAQNW
Q
P
G
HPLDPA
-
TTM
G
T
L
I
D
C
AH
A
D
S
V
HSF
I
RE
G
ESK
G
-
QL
L
LD
G
R
--
N--A
G
--
-
-
L
AA
AIG
PT
I
FVDVDPNAS
L
SR
EE
I
FGPVL
V
V
TRFTSE
E
Q
A
L
QL
ANDSQYGL
G
A
A
V
W
T
R
DL
SR
A
H
R
M
S
RR
LK
A
G
SV
F
VN
NYNDGDMTV
P
F
GG
Y
K
Q
SG
N
G
RDK
S
LHA
L
EK
F
TEL
K
T
I
W
I
S
L
EA
fig|331111.12.peg.1794
Escherichia coli E24377A
MNFHHLAYWQDKA
L
S
LAI
E
NR
L
F
ING
EYTAAAEN
---
ETFETV
D
P
V
T
QAP
L
AKIAR
G
KSV
D
I
D
R
AV
S
AA
RGV
F
ERGD
W
SLSS
P
AK
R
KAV
L
N
K
LA
D
L
M
E
AHAE
E
L
A
L
LE
TL
D
T
GK
PIRHSLRD
D
I
PGAARAIR
W
Y
A
E
AIDKVY
G
EVATTS
---
---SHELAMIV
R
E
P
V
GV
I
A
A
I
V
PWNFP
LL
L
TC
WK
LG
PALAAGN
S
V
I
L
KPSE
K
S
PL
S
A
I
RL
A
G
L
AK
EAG
L
P
D
GV
L
NVV
T
G
F
G
HEA
G
QA
L
S
R
H
N
D
I
DA
IA
F
TGS
TR
TGK
Q
L
LKD
A
G
D
S
N
M
KRV
W
LE
A
GGKS
A
N
IV
FA
D
C
S
D
-----
L
Q
K
A
ASSTAAGIFY
N
Q
GQVC
IAGT
R
L
LLEESIA
D
E
F
LALLKQQAQNW
Q
P
G
HPLDPA
-
TTM
G
T
L
I
D
C
AH
A
D
S
V
HSF
I
RE
G
EGK
G
-
QL
L
LD
G
R
--
N--A
E
--
-
-
L
AA
AIG
PT
I
FVDVDPNAS
L
SR
EE
I
FGPVL
V
V
TRFSSE
DQ
A
L
QL
ANDSQYGL
G
A
A
V
W
T
R
DL
SR
A
H
R
M
S
RR
LK
A
G
SV
F
VN
NYNDGDMTV
P
F
GG
Y
K
Q
SG
N
G
RDK
S
LHA
L
EK
F
TEL
K
T
I
W
I
S
L
EA
fig|331111.3.peg.3956
Escherichia coli E24377A
MNFHHLAYWQDKA
L
S
LAI
E
NR
L
F
ING
EYTAAAEN
---
ETFETV
D
P
V
T
QAP
L
AKIAR
G
KSV
D
I
D
R
AV
S
AA
RGV
F
ERGD
W
SLSS
P
AK
R
KAV
L
N
K
LA
D
L
M
E
AHAE
E
L
A
L
LE
TL
D
T
GK
PIRHSLRD
D
I
PGAARAIR
W
Y
A
E
AIDKVY
G
EVATTS
---
---SHELAMIV
R
E
P
V
GV
I
A
A
I
V
PWNFP
LL
L
TC
WK
LG
PALAAGN
S
V
I
L
KPSE
K
S
PL
S
A
I
RL
A
G
L
AK
EAG
L
P
D
GV
L
NVV
T
G
F
G
HEA
G
QA
L
S
R
H
N
D
I
DA
IA
F
TGS
TR
TGK
Q
L
LKD
A
G
D
S
N
M
KRV
W
LE
A
GGKS
A
N
IV
FA
D
C
S
D
-----
L
Q
K
A
ASSTAAGIFY
N
Q
GQVC
IAGT
R
L
LLEESIA
D
E
F
LALLKQQAQNW
Q
P
G
HPLDPA
-
TTM
G
T
L
I
D
C
AH
A
D
S
V
HSF
I
RE
G
EGK
G
-
QL
L
LD
G
R
--
N--A
E
--
-
-
L
AA
AIG
PT
I
FVDVDPNAS
L
SR
EE
I
FGPVL
V
V
TRFSSE
DQ
A
L
QL
ANDSQYGL
G
A
A
V
W
T
R
DL
SR
A
H
R
M
S
RR
LK
A
G
SV
F
VN
NYNDGDMTV
P
F
GG
Y
K
Q
SG
N
G
RDK
S
LHA
L
EK
F
TEL
K
T
I
W
I
S
L
EA
fig|340186.3.peg.332
Escherichia coli E110019
MNFHHLAYWQDKA
L
S
LAI
E
NR
L
F
ING
EYTAAAEN
ETF
ETFETV
D
P
V
T
QAP
L
AKIAR
G
KSV
D
I
D
R
A
M
S
AA
RGV
F
ERGD
W
SLSS
P
AK
R
KAV
L
N
K
LA
D
L
M
E
AHAE
E
L
A
L
LE
TL
D
T
GK
PIRHSLRD
D
I
PGAARAIR
W
Y
A
E
AIDKVY
G
EVATTS
---
---SHELAMIV
R
E
P
V
GV
I
A
A
I
V
PWNFP
LL
L
TC
WK
LG
PALAAGN
S
V
I
L
KPSE
K
S
PL
S
A
I
RL
A
G
L
AK
EAG
L
P
D
GV
L
NVV
T
G
F
G
HEA
G
QA
L
S
R
H
N
D
I
DA
IA
F
TGS
TR
TGK
Q
L
LKD
A
G
D
S
N
M
KRV
W
LE
A
GGKS
A
N
IV
FA
D
CP
D
-----
L
Q
K
A
ASSTAAGIFY
N
Q
GQVC
IAGT
R
L
LLEESIA
D
E
F
LALLKQQAQNW
Q
P
G
HPLDPA
-
TTM
G
T
L
I
D
C
AH
A
D
S
V
HSF
I
RE
G
ESK
G
-
QL
L
LD
G
R
--
N--A
E
--
-
-
L
AA
AIG
PT
I
FVDVDPNAS
L
SR
EE
I
FGPVL
V
V
TRFTSE
DQ
A
L
QL
ANDSQYGL
G
A
A
V
W
T
R
DL
SR
A
H
R
M
S
RR
LK
A
G
SV
F
VN
NYNDGDMTV
P
F
GG
Y
K
Q
SG
N
G
RDK
S
LHA
L
EK
F
TEL
K
T
I
W
I
S
L
EA
fig|340186.5.peg.351
Escherichia coli E110019
MNFHHLAYWQDKA
L
S
LAI
E
NR
L
F
ING
EYTAAAEN
ETF
ETFETV
D
P
V
T
QAP
L
AKIAR
G
KSV
D
I
D
R
A
M
S
AA
RGV
F
ERGD
W
SLSS
P
AK
R
KAV
L
N
K
LA
D
L
M
E
AHAE
E
L
A
L
LE
TL
D
T
GK
PIRHSLRD
D
I
PGAARAIR
W
Y
A
E
AIDKVY
G
EVATTS
---
---SHELAMIV
R
E
P
V
GV
I
A
A
I
V
PWNFP
LL
L
TC
WK
LG
PALAAGN
S
V
I
L
KPSE
K
S
PL
S
A
I
RL
A
G
L
AK
EAG
L
P
D
GV
L
NVV
T
G
F
G
HEA
G
QA
L
S
R
H
N
D
I
DA
IA
F
TGS
TR
TGK
Q
L
LKD
A
G
D
S
N
M
KRV
W
LE
A
GGKS
A
N
IV
FA
D
CP
D
-----
L
Q
K
A
ASSTAAGIFY
N
Q
GQVC
IAGT
R
L
LLEESIA
D
E
F
LALLKQQAQNW
Q
P
G
HPLDPA
-
TTM
G
T
L
I
D
C
AH
A
D
S
V
HSF
I
RE
G
ESK
G
-
QL
L
LD
G
R
--
N--A
E
--
-
-
L
AA
AIG
PT
I
FVDVDPNAS
L
SR
EE
I
FGPVL
V
V
TRFTSE
DQ
A
L
QL
ANDSQYGL
G
A
A
V
W
T
R
DL
SR
A
H
R
M
S
RR
LK
A
G
SV
F
VN
NYNDGDMTV
P
F
GG
Y
K
Q
SG
N
G
RDK
S
LHA
L
EK
F
TEL
K
T
I
W
I
S
L
EA
fig|358709.5.peg.1633
Escherichia coli 101-1
MNFHHLAYWQDKA
L
S
LAI
E
NR
L
F
ING
EYTAAAEN
---
ETFETV
D
P
V
T
QAP
L
AKIAR
G
KSV
D
I
D
R
A
M
S
AA
HGV
F
ERGD
W
SLSS
P
AK
R
KAV
L
N
K
LA
D
L
M
E
AHAE
E
L
A
L
LE
TL
D
T
GK
PIRHSLRD
D
I
PGAARAIR
W
Y
A
E
AIDKVY
G
EVATTS
---
---SHELAMIV
R
E
P
V
GV
I
A
A
I
V
PWNFP
LL
L
TC
WK
LG
PALAAGN
S
V
I
L
KPSE
K
S
PL
S
A
I
RL
A
G
L
AK
EAG
L
P
D
GV
L
NVV
T
G
F
G
HEA
G
QA
L
S
R
H
N
D
I
DA
IA
F
TGS
TR
TGK
Q
L
LKD
A
G
D
S
N
M
KRV
W
LE
A
GGKS
A
N
IV
FA
D
CP
D
-----
L
Q
Q
A
ASATAAGIFY
N
Q
GQVC
IAGT
R
L
LLEESIA
D
E
F
LALLKQQAQNW
Q
P
G
HPLDPA
-
TTM
G
T
L
I
D
C
AH
A
D
S
V
HSF
I
RE
G
ESK
G
-
QL
L
LD
G
R
--
N--A
G
--
-
-
L
AA
AIG
PT
I
FVDVDPNAS
L
SR
EE
I
FGPVL
V
V
TRFTSE
E
Q
A
L
QL
ANDSQYGL
G
A
A
V
W
T
R
DL
SR
A
H
R
M
S
RR
LK
A
G
SV
F
VN
NYNDGDMTV
P
F
GG
Y
K
Q
SG
N
G
RDK
S
LHA
L
EK
F
TEL
K
T
I
W
I
S
L
EA
fig|656393.3.peg.2076
Escherichia coli H299
MNFHHLAYWQDKA
L
S
LAI
E
TR
L
F
ING
EYTAAAEN
---
ETFETV
D
P
V
T
QAP
L
ANIAR
G
KSV
D
I
D
R
AV
S
AA
RGV
F
ERGD
W
SLSS
P
AK
R
KAV
L
N
K
LA
D
L
M
E
ANAE
E
L
A
L
LE
TL
D
T
GK
PIRHSLRD
D
I
PGAARAIR
W
Y
A
E
AIDKVY
G
EVATTS
---
---SHELAMIV
R
E
P
V
GV
I
A
A
I
V
PWNFP
LL
L
TC
WK
LG
PALAAGN
S
V
I
L
KPSE
K
S
PL
S
A
I
RL
A
G
L
AK
EAG
L
P
D
GV
L
NVV
T
G
F
G
HEA
G
QA
L
S
R
H
N
D
I
DA
IA
F
TGS
TR
TGK
Q
L
LKD
A
G
D
S
N
M
KRV
W
LE
A
GGKS
A
N
IV
FA
D
CP
D
-----
L
Q
K
A
ASATAAGIFY
N
Q
GQVC
IAGT
R
L
LLEESIA
D
E
F
LALLKQQAQNW
Q
P
G
HPLDPA
-
TTM
G
T
L
I
D
C
AH
A
D
S
V
HSF
I
RE
G
ESK
G
-
QL
L
LD
G
R
--
N--A
E
--
-
-
L
AA
AIG
PT
I
FVEVDPNAS
L
SR
EE
I
FGPVL
V
V
TRFTSE
E
Q
A
L
QL
ANDSQYGL
G
A
A
V
W
T
R
DL
SR
A
H
R
M
S
RR
LK
A
G
SV
F
VN
NYNDGDMTV
P
F
GG
Y
K
Q
SG
N
G
RDK
S
LHA
L
EK
F
TEL
K
T
I
W
I
S
L
EA
fig|550676.3.peg.862
Escherichia coli B185
MNFHHLAYWQDKA
L
S
LAI
E
TR
L
F
ING
EYTAAAEN
---
ETFETV
D
P
V
T
QAP
L
AKIAR
G
KSV
D
I
D
R
AV
S
AA
RGV
F
ERGD
W
SLSS
P
AK
R
KAV
L
N
K
LA
D
L
M
E
ANAE
E
L
A
L
LE
TL
D
T
GK
PIRHSLRD
D
I
PGAARAIR
W
Y
A
E
AIDKVY
G
EVATTS
---
---SHELAMIV
R
E
P
V
GV
I
A
A
I
V
PWNFP
LL
L
TC
WK
LG
PALAAGN
S
V
I
L
KPSE
K
S
PL
S
A
I
RL
A
G
L
AK
EAG
L
P
D
GV
L
NVV
T
G
F
G
HEA
G
QA
L
S
R
H
N
D
I
DA
IA
F
TGS
TR
TGK
Q
L
LKD
A
G
D
S
N
M
KRV
W
LE
A
GGKS
A
N
IV
FA
D
CP
D
-----
L
Q
K
A
ASATAAGIFY
N
Q
GQVC
IAGT
R
L
LLEESIA
D
E
F
LALLKQQAQNW
Q
P
G
HPLDPA
-
TTM
G
T
L
I
D
C
AH
A
D
S
V
HSF
I
RE
G
ESK
G
-
QL
L
LD
G
R
--
N--A
G
--
-
-
L
AA
AIG
PT
I
FVDLDPNAS
L
SR
EE
I
FGPVL
V
V
TRFTSE
E
Q
A
L
QL
ANDSQYGL
G
A
A
V
W
T
R
DL
SR
A
H
R
M
S
RR
LK
A
G
SV
F
VN
NYNDGDMTV
P
F
GG
Y
K
Q
SG
N
G
RDK
S
LHA
L
EK
F
TEL
K
T
I
W
I
S
L
EA
fig|656379.3.peg.3395
Escherichia coli FVEC1302
MNFHHLAYWQDKA
L
S
LAI
E
TR
L
F
ING
EYTAAAEN
---
ETFETV
D
P
V
T
QAP
L
ANIAR
G
KSV
D
I
D
R
AV
S
AA
RGV
F
ERGD
W
SLSS
P
AK
R
KAV
L
N
K
LA
D
L
M
E
ANAE
E
L
A
L
LE
TL
D
T
GK
PIRHSLRD
D
I
PGAARAIR
W
Y
A
E
AIDKVY
G
EVATTS
---
---SHELAMIV
R
E
P
V
GV
I
A
A
I
V
PWNFP
LL
L
TC
WK
LG
PALAAGN
S
V
I
L
KPSE
K
S
PL
S
A
I
RL
A
G
L
AK
EAG
L
P
D
GV
L
NVV
T
G
F
G
HEA
G
QA
L
S
R
H
N
D
I
DA
IA
F
TGS
TR
TGK
Q
L
LKD
A
G
D
S
N
M
KRV
W
LE
A
GGKS
A
N
IV
FA
D
CP
D
-----
L
Q
K
A
ASATAAGIFY
N
Q
GQVC
IAGT
R
L
LLEESIA
D
E
F
LALLKQQAQNW
Q
P
G
HPLDPA
-
TTM
G
T
L
I
D
C
AH
A
D
S
V
HSF
I
RE
G
ESK
G
-
QL
L
LD
G
R
--
N--A
E
--
-
-
L
AA
AIG
PT
I
FVEVDPNAS
L
SR
EE
I
FGPVL
V
V
TRFTSE
E
Q
A
L
QL
ANDSQYGL
G
A
A
V
W
T
R
DL
SR
A
H
R
M
S
RR
LK
V
G
SV
F
VN
NYNDGDMTV
P
F
GG
Y
K
Q
SG
N
G
RDK
S
LHA
L
EK
F
TEL
K
T
I
W
I
S
L
EA
fig|656380.3.peg.2747
Escherichia coli FVEC1412
MNFHHLAYWQDKA
L
S
LAI
E
TR
L
F
ING
EYTAAAEN
---
ETFETV
D
P
V
T
QAP
L
ANIAR
G
KSV
D
I
D
R
AV
S
AA
RGV
F
ERGD
W
SLSS
P
AK
R
KAV
L
N
K
LA
D
L
M
E
ANAE
E
L
A
L
LE
TL
D
T
GK
PIRHSLRD
D
I
PGAARAIR
W
Y
A
E
AIDKVY
G
EVATTS
---
---SHELAMIV
R
E
P
V
GV
I
A
A
I
V
PWNFP
LL
L
TC
WK
LG
PALAAGN
S
V
I
L
KPSE
K
S
PL
S
A
I
RL
A
G
L
AK
EAG
L
P
D
GV
L
NVV
T
G
F
G
HEA
G
QA
L
S
R
H
N
D
I
DA
IA
F
TGS
TR
TGK
Q
L
LKD
A
G
D
S
N
M
KRV
W
LE
A
GGKS
A
N
IV
FA
D
CP
D
-----
L
Q
K
A
ASATAAGIFY
N
Q
GQVC
IAGT
R
L
LLEESIA
D
E
F
LALLKQQAQNW
Q
P
G
HPLDPA
-
TTM
G
T
L
I
D
C
AH
A
D
S
V
HSF
I
RE
G
ESK
G
-
QL
L
LD
G
R
--
N--A
E
--
-
-
L
AA
AIG
PT
I
FVEVDPNAS
L
SR
EE
I
FGPVL
V
V
TRFTSE
E
Q
A
L
QL
ANDSQYGL
G
A
A
V
W
T
R
DL
SR
A
H
R
M
S
RR
LK
V
G
SV
F
VN
NYNDGDMTV
P
F
GG
Y
K
Q
SG
N
G
RDK
S
LHA
L
EK
F
TEL
K
T
I
W
I
S
L
EA
fig|749549.3.peg.1507
Escherichia coli MS 198-1
MNFHHLAYWQDKA
L
S
LAI
E
TR
L
F
ING
EYTAAAEN
---
ETFETV
D
P
V
T
QAP
L
ANIAR
G
KSV
D
I
D
R
AV
S
AA
RGV
F
ERGD
W
SLSS
P
AK
R
KAV
L
N
K
LA
D
L
M
E
ANAE
E
L
A
L
LE
TL
D
T
GK
PIRHSLRD
D
I
PGAARAIR
W
Y
A
E
AIDKVY
G
EVATTS
---
---SHELAMIV
R
E
P
V
GV
I
A
A
I
V
PWNFP
LL
L
TC
WK
LG
PALAAGN
S
V
I
L
KPSE
K
S
PL
S
A
I
RL
A
G
L
AK
EAG
L
P
D
GV
L
NVV
T
G
F
G
HEA
G
QA
L
S
R
H
N
D
I
DA
IA
F
TGS
TR
TGK
Q
L
LKD
A
G
D
S
N
M
KRV
W
LE
A
GGKS
A
N
IV
FA
D
CP
D
-----
L
Q
K
A
ASATAAGIFY
N
Q
GQVC
IAGT
R
L
LLEESIA
D
E
F
LALLKQQAQNW
Q
P
G
HPLDPA
-
TTM
G
T
L
I
D
C
AH
A
D
S
V
HSF
I
RE
G
ESK
G
-
QL
L
LD
G
R
--
N--A
E
--
-
-
L
AA
AIG
PT
I
FVEVDPNAS
L
SR
EE
I
FGPVL
V
V
TRFTSE
E
Q
A
L
QL
ANDSQYGL
G
A
A
V
W
T
R
DL
SR
A
H
R
M
S
RR
LK
V
G
SV
F
VN
NYNDGDMTV
P
F
GG
Y
K
Q
SG
N
G
RDK
S
LHA
L
EK
F
TEL
K
T
I
W
I
S
L
EA
fig|585056.7.peg.1799
Escherichia coli UMN026
MNFHHLAYWQDKA
L
S
LAI
E
TR
L
F
ING
EYTAAAEN
---
ETFETV
D
P
V
T
QAP
L
ANIAR
G
KSV
D
I
D
R
AV
S
AA
RGV
F
ERGD
W
SLSS
P
AK
R
KAV
L
N
K
LA
D
L
M
E
ANAE
E
L
A
L
LE
TL
D
T
GK
PIRHSLRD
D
I
PGAARAIR
W
Y
A
E
AIDKVY
G
EVATTS
---
---SHELAMIV
R
E
P
V
GV
I
A
A
I
V
PWNFP
LL
L
TC
WK
LG
PALAAGN
S
V
I
L
KPSE
K
S
PL
S
A
I
RL
A
G
L
AK
EAG
L
P
D
GV
L
NVV
T
G
F
G
HEA
G
QA
L
S
R
H
N
D
I
DA
IA
F
TGS
TR
TGK
Q
L
LKD
A
G
D
S
N
M
KRV
W
LE
A
GGKS
A
N
IV
FA
D
CP
D
-----
L
Q
K
A
ASATAAGIFY
N
Q
GQVC
IAGT
R
L
LLEESIA
D
E
F
LALLKQQAQNW
Q
P
G
HPLDPA
-
TTM
G
T
L
I
D
C
AH
A
D
S
V
HSF
I
RE
G
ESK
G
-
QL
L
LD
G
R
--
N--A
E
--
-
-
L
AA
AIG
PT
I
FVEVDPNAS
L
SR
EE
I
FGPVL
V
V
TRFTSE
E
Q
A
L
QL
ANDSQYGL
G
A
A
V
W
T
R
DL
SR
A
H
R
M
S
RR
LK
V
G
SV
F
VN
NYNDGDMTV
P
F
GG
Y
K
Q
SG
N
G
RDK
S
LHA
L
EK
F
TEL
K
T
I
W
I
S
L
EA
fig|216592.1.peg.1818
Escherichia coli 042 (33-527/527)
MNFHHLAYWQDKA
L
S
LAI
E
TR
L
F
ING
EYTAAAEN
---
ETFETV
D
P
V
T
QAP
L
AKIAR
G
KSV
D
I
D
R
AV
S
AA
RGV
F
ERGD
W
SLSS
P
AK
R
KAV
L
N
K
LA
D
L
M
E
ANAE
E
L
A
L
LE
TL
D
T
GK
PIRHSLRD
D
I
PGAARAIR
W
Y
A
E
AIDKVY
G
EVATTS
---
---SHELAMIV
R
E
P
V
GV
I
A
A
I
V
PWNFP
LL
L
TC
WK
LG
PALAAGN
S
V
I
L
KPSE
K
S
PL
S
A
I
RL
A
G
L
AK
EAG
L
P
D
GV
L
NVV
T
G
F
G
HEA
G
QA
L
S
R
H
N
D
I
DA
IA
F
TGS
TR
TGK
Q
L
LKD
A
G
D
S
N
M
KRV
W
LE
A
GGKS
A
N
IV
FA
D
CP
D
-----
L
Q
Q
A
ASATAAGIFY
N
Q
GQVC
IAGT
R
L
LLEESIA
D
E
F
LDLLKQQAQNW
Q
P
G
HPLDPA
-
TTM
G
T
L
I
D
C
AH
A
D
S
V
HSF
I
RE
G
ESK
G
-
QL
L
LD
G
R
--
N--A
E
--
-
-
L
AA
AIG
PT
I
FVEVDPNAS
L
SR
EE
I
FGPVL
V
V
TRFTSE
E
Q
A
L
QL
ANDSQYGL
G
A
A
V
W
T
R
DL
SR
A
H
R
M
S
RR
LK
A
G
SV
F
VN
NYNDGDMTV
P
F
GG
Y
K
Q
SG
N
G
RDK
S
LHA
L
EK
F
TEL
K
T
I
W
I
S
L
EA
fig|216592.3.peg.1480
Escherichia coli 042
MNFHHLAYWQDKA
L
S
LAI
E
TR
L
F
ING
EYTAAAEN
---
ETFETV
D
P
V
T
QAP
L
AKIAR
G
KSV
D
I
D
R
AV
S
AA
RGV
F
ERGD
W
SLSS
P
AK
R
KAV
L
N
K
LA
D
L
M
E
ANAE
E
L
A
L
LE
TL
D
T
GK
PIRHSLRD
D
I
PGAARAIR
W
Y
A
E
AIDKVY
G
EVATTS
---
---SHELAMIV
R
E
P
V
GV
I
A
A
I
V
PWNFP
LL
L
TC
WK
LG
PALAAGN
S
V
I
L
KPSE
K
S
PL
S
A
I
RL
A
G
L
AK
EAG
L
P
D
GV
L
NVV
T
G
F
G
HEA
G
QA
L
S
R
H
N
D
I
DA
IA
F
TGS
TR
TGK
Q
L
LKD
A
G
D
S
N
M
KRV
W
LE
A
GGKS
A
N
IV
FA
D
CP
D
-----
L
Q
Q
A
ASATAAGIFY
N
Q
GQVC
IAGT
R
L
LLEESIA
D
E
F
LDLLKQQAQNW
Q
P
G
HPLDPA
-
TTM
G
T
L
I
D
C
AH
A
D
S
V
HSF
I
RE
G
ESK
G
-
QL
L
LD
G
R
--
N--A
E
--
-
-
L
AA
AIG
PT
I
FVEVDPNAS
L
SR
EE
I
FGPVL
V
V
TRFTSE
E
Q
A
L
QL
ANDSQYGL
G
A
A
V
W
T
R
DL
SR
A
H
R
M
S
RR
LK
A
G
SV
F
VN
NYNDGDMTV
P
F
GG
Y
K
Q
SG
N
G
RDK
S
LHA
L
EK
F
TEL
K
T
I
W
I
S
L
EA
fig|656444.3.peg.2038
Escherichia coli TA280
MNFHHLAYWQDKA
L
S
LAI
E
TR
L
F
ING
EYTAAAEN
---
ETFETV
D
P
V
T
QAP
L
AKIAR
G
KSV
D
I
D
R
AV
S
AA
RGV
F
ERGD
W
SLSS
P
AK
R
KAV
L
N
K
LA
D
L
M
E
ANAE
E
L
A
L
LE
TL
D
T
GK
PIRHSLRD
D
I
PGAARAIR
W
Y
A
E
AIDKVY
G
EVATTS
---
---SHELAMIV
R
E
P
V
GV
I
A
A
I
V
PWNFP
LL
L
TC
WK
LG
PALAAGN
S
V
I
L
KPSE
K
S
PL
S
A
I
RL
A
G
L
AK
EAG
L
P
D
GV
L
NVV
T
G
F
G
HEA
G
QA
L
S
R
H
N
D
I
DA
IA
F
TGS
TR
TGK
Q
L
LKD
A
G
D
S
N
M
KRV
W
LE
A
GGKS
A
N
IV
FA
D
CP
D
-----
L
Q
Q
A
ASATAAGIFY
N
Q
GQVC
IAGT
R
L
LLEESIA
D
E
F
LDLLKQQAQNW
Q
P
G
HPLDPA
-
TTM
G
T
L
I
D
C
AH
A
D
S
V
HSF
I
RE
G
ESK
G
-
QL
L
LD
G
R
--
N--A
E
--
-
-
L
AA
AIG
PT
I
FVEVDPNAS
L
SR
EE
I
FGPVL
V
V
TRFTSE
E
Q
A
L
QL
ANDSQYGL
G
A
A
V
W
T
R
DL
SR
A
H
R
M
S
RR
LK
A
G
SV
F
VN
NYNDGDMTV
P
F
GG
Y
K
Q
SG
N
G
RDK
S
LHA
L
EK
F
TEL
K
T
I
W
I
S
L
EA
fig|749527.3.peg.424
Escherichia coli MS 21-1
MNFHHLAYWQDKA
L
S
LAI
E
TR
L
F
ING
EYTAAAEN
---
ETFETV
D
P
V
T
QAP
L
AKIAR
G
KSV
D
I
D
R
AV
S
AA
RGV
F
ERGD
W
SLSS
P
AK
R
KAV
L
N
K
LA
D
L
M
E
ANAE
E
L
A
L
LE
TL
D
T
GK
PIRHSLRD
D
I
PGAARAIR
W
Y
A
E
AIDKVY
G
EVATTS
---
---SHELAMIV
R
E
P
V
GV
I
A
A
I
V
PWNFP
LL
L
TC
WK
LG
PALAAGN
S
V
I
L
KPSE
K
S
PL
S
A
I
RL
A
G
L
AK
EAG
L
P
D
GV
L
NVV
T
G
F
G
HEA
G
QA
L
S
R
H
N
D
I
DA
IA
F
TGS
TR
TGK
Q
L
LKD
A
G
D
S
N
M
KRV
W
LE
A
GGKS
A
N
IV
FA
D
CP
D
-----
L
Q
Q
A
ASATAAGIFY
N
Q
GQVC
IAGT
R
L
LLEENIA
D
E
F
LALLKQQAQNW
Q
P
G
HPLDPA
-
TTM
G
T
L
I
D
C
AH
A
D
S
V
HSF
I
RE
G
ESK
G
-
QL
L
LD
G
R
--
N--A
E
--
-
-
L
AA
AIG
PT
I
FVEVDPNAS
L
SR
EE
I
FGPVL
V
V
TRFTSE
E
Q
A
L
QL
ANDSQYGL
G
A
A
V
W
T
R
DL
SR
A
H
R
L
S
RR
LK
A
G
SV
F
VN
NYNDGDMTV
P
F
GG
Y
K
Q
SG
N
G
RDK
S
LHA
L
EK
F
TEL
K
T
I
W
I
S
L
EA
fig|749531.3.peg.280
Escherichia coli MS 69-1
MNFHHLAYWQDKA
L
S
LAI
E
TR
L
F
ING
EYTAAAEN
---
ETFETV
D
P
V
T
QAP
L
ANIAR
G
KSV
D
I
D
R
AV
S
AA
RGV
F
ERGD
W
SLSS
P
AK
R
KAV
L
N
K
LA
D
L
M
E
ANAE
E
L
A
L
LE
TL
D
T
GK
PIRHSLRD
D
I
PGAARAIR
W
Y
A
E
AIDKVY
G
EVATTS
---
---SHELAMIV
R
E
P
V
GV
I
A
A
I
V
PWNFP
LL
L
TC
WK
LG
PALAAGN
S
V
I
L
KPSE
K
S
PL
S
A
I
RL
A
G
L
AK
EAG
L
P
D
GV
L
NVV
T
G
F
G
HEA
G
QA
L
S
R
H
N
D
I
DA
IA
F
TGS
TR
TGK
Q
L
LKD
A
G
D
S
N
M
KRV
W
LE
A
GGKS
A
N
IV
FA
D
CP
D
-----
L
Q
K
A
ASATAAGIFY
N
Q
GQVC
IAGT
R
L
LLEESIA
D
E
F
LDLLKQQAQNW
Q
P
G
HPLDPA
-
TTM
G
T
L
I
D
C
AH
A
D
S
V
HSF
I
RE
G
ESK
G
-
QL
L
LD
G
R
--
N--A
E
--
-
-
L
AA
AIG
PT
I
FVDVDPDAS
L
SR
EE
I
FGPVL
V
V
TRFTSE
E
Q
A
L
QL
ANDSQYGL
G
A
A
V
W
T
R
DL
SR
A
H
R
M
S
RR
LK
A
G
SV
F
VN
NYNDGDMTV
P
F
GG
Y
K
Q
SG
N
G
RDK
S
LHA
L
EK
F
TEL
K
T
I
W
I
S
L
EA
fig|439855.10.peg.1978
Escherichia coli SMS-3-5
MNFHHLAYWQDKA
L
S
LAI
E
TR
L
F
ING
EYTAAAEN
---
ETFETV
D
P
V
T
QAP
L
AKIAR
G
KSV
D
I
D
R
AV
S
AA
RGV
F
ERGD
W
SLSS
P
AK
R
KAV
L
N
K
LA
D
L
M
E
ANAE
E
L
A
L
LE
TL
D
T
GK
PIRHSLRD
D
I
PGAARAIR
W
Y
A
E
AIDKVY
G
EVATTS
---
---SHELAMIV
R
E
P
V
GV
I
A
A
I
V
PWNFP
LL
L
TC
WK
LG
PALAAGN
S
V
I
L
KPSE
K
S
PL
S
A
I
RL
A
G
L
AK
EAG
L
P
D
GV
L
NVV
T
G
F
G
HEA
G
QA
L
S
R
H
N
D
I
DA
IA
F
TGS
TR
TGK
Q
L
LKD
A
G
D
S
N
M
KRV
W
LE
A
GGKS
A
N
IV
FA
D
CP
D
-----
L
Q
Q
A
ASATAAGIFY
N
Q
GQVC
IAGT
R
L
LLEESIA
D
E
F
LALLKQQAQNW
Q
P
G
HPLDPA
-
TTM
G
T
L
I
D
C
AH
A
D
S
V
HSF
I
RE
G
ESK
G
-
QL
L
LD
G
R
--
N--A
E
--
-
-
L
AA
AIG
PT
I
FVEVDPNAS
L
SR
EE
I
FGPVL
V
V
TRFTSE
E
Q
A
L
QL
AND
C
QYGL
G
A
A
V
W
T
R
DL
SR
A
H
R
M
S
RR
LK
A
G
SV
F
VN
NYNDGDMTV
P
F
GG
Y
K
Q
SG
N
G
RDK
S
LHA
L
DK
F
TEL
K
T
I
W
I
S
L
EA
fig|656437.3.peg.1464
Escherichia coli TA143
MNFHHLAYWQDKA
L
S
LAI
E
TR
L
F
ING
EYTAAAEN
---
ETFETV
D
P
V
T
QAP
L
AKIAR
G
KSV
D
I
D
R
AV
S
AA
RGV
F
ERGD
W
SLSS
P
AK
R
KAV
L
N
K
LA
D
L
M
E
ANAE
E
L
A
L
LE
TL
D
T
GK
PIRHSLRD
D
I
PGAARAIR
W
Y
A
E
AIDKVY
G
EVATTS
---
---SHELAMIV
R
E
P
V
GV
I
A
A
I
V
PWNFP
LL
L
TC
WK
LG
PALAAGN
S
V
I
L
KPSE
K
S
PL
S
A
I
RL
A
G
L
AK
EAG
L
P
D
GV
L
NVV
T
G
F
G
HEA
G
QA
L
S
R
H
N
D
I
DA
IA
F
TGS
TR
TGK
Q
L
LKD
A
G
D
S
N
M
KRV
W
LE
A
GGKS
A
N
IV
FA
D
CP
D
-----
L
Q
Q
A
ASATAAGIFY
N
Q
GQVC
IAGT
R
L
LLEESIA
D
E
F
LDLLKQQAQNW
Q
P
G
HPLDPA
-
TTM
G
T
L
I
D
C
AH
A
D
S
V
HSF
I
RE
G
ESK
G
-
QL
L
LD
G
R
--
N--A
E
--
-
-
L
AA
AIG
PT
I
FVDVDPDAS
L
SR
EE
I
FGPVL
V
V
TRFTSE
E
Q
A
L
QL
ANDSQYGL
G
A
A
V
W
T
R
DL
SC
A
H
R
M
S
RR
LK
A
G
SV
F
VN
NYNDGDMTV
P
F
GG
Y
K
Q
SG
N
G
RDK
S
LHA
L
EK
F
TEL
K
T
I
W
I
S
L
EA
fig|585057.4.peg.1725
Escherichia coli IAI39
MNFHHLAYWQDKA
L
S
LAI
E
TR
L
F
ING
EYTAAAEN
---
ETFETV
D
P
V
T
QAP
L
AKIAR
G
KSV
D
I
D
R
AV
S
AA
RGV
F
ERGD
W
SLSS
P
AK
R
KAV
L
N
K
LA
D
L
M
E
ANAE
E
L
A
L
LE
TL
D
T
GK
PIRHSLRD
D
I
PGAARAIR
W
Y
A
E
AIDKVY
G
EVATTS
---
---IHELAMIV
R
E
P
V
GV
I
A
A
I
V
PWNFP
LL
L
TC
WK
LG
PALAAGN
S
V
I
L
KPSE
K
S
PL
S
A
I
RL
A
G
L
AK
EAG
L
P
D
GV
L
NVV
T
G
F
G
HEA
G
QA
L
S
R
H
N
D
I
DA
IA
F
TGS
TR
TGK
Q
L
LKD
A
G
D
S
N
M
KRV
W
LE
A
GGKS
A
N
IV
FA
D
CP
N
-----
L
Q
Q
A
ASATAAGIFY
N
Q
GQVC
IAGT
R
L
LLEESIA
D
E
F
LALLKQQAQNW
Q
P
G
HPLDPA
-
TTM
G
T
L
I
D
C
AH
A
D
S
V
HSF
I
RE
G
EGK
G
-
QL
L
LD
G
R
--
N--A
E
--
-
-
L
AA
AIG
PT
I
FVEVDPNAS
L
SR
EE
I
FGPVL
V
V
TRFTSE
E
Q
A
L
QL
ANDSQYGL
G
A
A
V
W
T
R
DL
SR
A
H
R
M
S
RR
LK
A
G
SV
F
VN
NYNDGDMTV
P
F
GG
Y
K
Q
SG
N
G
RDK
S
LHA
L
EK
F
TEL
K
T
I
W
I
S
L
EA
fig|585057.6.peg.1725
Escherichia coli IAI39
MNFHHLAYWQDKA
L
S
LAI
E
TR
L
F
ING
EYTAAAEN
---
ETFETV
D
P
V
T
QAP
L
AKIAR
G
KSV
D
I
D
R
AV
S
AA
RGV
F
ERGD
W
SLSS
P
AK
R
KAV
L
N
K
LA
D
L
M
E
ANAE
E
L
A
L
LE
TL
D
T
GK
PIRHSLRD
D
I
PGAARAIR
W
Y
A
E
AIDKVY
G
EVATTS
---
---IHELAMIV
R
E
P
V
GV
I
A
A
I
V
PWNFP
LL
L
TC
WK
LG
PALAAGN
S
V
I
L
KPSE
K
S
PL
S
A
I
RL
A
G
L
AK
EAG
L
P
D
GV
L
NVV
T
G
F
G
HEA
G
QA
L
S
R
H
N
D
I
DA
IA
F
TGS
TR
TGK
Q
L
LKD
A
G
D
S
N
M
KRV
W
LE
A
GGKS
A
N
IV
FA
D
CP
N
-----
L
Q
Q
A
ASATAAGIFY
N
Q
GQVC
IAGT
R
L
LLEESIA
D
E
F
LALLKQQAQNW
Q
P
G
HPLDPA
-
TTM
G
T
L
I
D
C
AH
A
D
S
V
HSF
I
RE
G
EGK
G
-
QL
L
LD
G
R
--
N--A
E
--
-
-
L
AA
AIG
PT
I
FVEVDPNAS
L
SR
EE
I
FGPVL
V
V
TRFTSE
E
Q
A
L
QL
ANDSQYGL
G
A
A
V
W
T
R
DL
SR
A
H
R
M
S
RR
LK
A
G
SV
F
VN
NYNDGDMTV
P
F
GG
Y
K
Q
SG
N
G
RDK
S
LHA
L
EK
F
TEL
K
T
I
W
I
S
L
EA
fig|656419.3.peg.1654
Escherichia coli M718
MNFHHLAYWQDKA
L
S
LAI
E
TR
L
F
ING
EYTAAAEN
---
ETFETV
D
P
V
T
QAP
L
AKIAR
G
KSV
D
I
D
R
AV
S
AA
RGV
F
ERGD
W
SLSS
P
AK
R
KAV
L
N
K
LA
D
L
M
E
ANAE
E
L
A
L
LE
TL
D
T
GK
PIRHSLRD
D
I
PGAARAIR
W
Y
A
E
AIDKVY
G
EVATTS
---
---SHELAMIV
R
E
P
V
GV
I
A
A
I
V
PWNFP
LL
L
TC
WK
LG
PALAAGN
S
VV
L
KPSE
K
S
PL
S
A
I
RL
A
G
L
AK
EAG
L
P
D
GV
L
NVV
T
G
F
G
HEA
G
QA
L
S
R
H
N
D
I
DA
IA
F
TGS
TR
TGK
Q
L
LKD
A
G
D
S
N
M
KRV
W
LE
A
GGKS
A
N
IV
FA
D
CP
D
-----
L
Q
K
A
ASATAAGIFY
N
Q
GQVC
IAGT
R
L
LLEESIA
D
E
F
LALLKQQAQNW
Q
P
G
HPLDPA
-
TTM
G
T
L
I
D
C
AH
A
D
S
V
HSF
I
RE
G
EGK
G
-
QL
L
LD
G
R
--
N--A
G
--
-
-
L
AA
AIG
PT
I
FVDVAPNAS
L
SR
EE
I
FGPVL
V
V
TRFKLE
DQ
A
L
QL
ANDSQYGL
G
A
A
V
W
T
R
DL
SR
A
H
R
M
S
RR
LK
A
G
SV
F
VN
NYNDGDMTV
P
F
GG
Y
K
Q
SG
N
G
RDK
S
LHA
L
EK
F
TEL
K
T
I
W
I
S
L
EA
fig|562.371.peg.1398
Escherichia coli 1044A
MNFHHLAYWQDKA
L
S
LAI
E
NR
L
F
ING
EYTAAAEN
---
ETFETV
D
P
V
T
QAP
L
ANIAR
G
KSV
D
I
D
R
AV
S
AA
RGV
F
ERGD
W
SLSS
P
AK
R
KAV
L
N
K
LA
D
L
IE
ANAE
E
L
A
L
LE
TL
D
T
GK
PIRHSLRD
D
I
PGAARAIR
W
Y
A
E
AIDKVY
G
EVATTS
---
---SHELAMIV
R
E
P
V
GV
I
A
A
I
V
PWNFP
LL
L
TC
WK
LG
PALAAGN
S
VV
L
KPSE
K
S
PL
S
A
I
RL
A
G
L
AK
EAG
L
P
D
GV
L
NVV
T
G
F
G
HEA
G
QA
L
S
R
H
N
D
I
DA
IA
F
TGS
TR
TGK
Q
L
LKD
A
G
D
S
N
M
KRV
W
LE
A
GGKS
A
N
IV
FA
D
CP
D
-----
L
Q
Q
A
ASATAAGIFY
N
Q
GQVC
IAGT
R
L
LLEESIA
D
E
F
LALLKQQAQNW
Q
P
G
HPLDPA
-
TTM
G
T
L
I
D
C
AH
A
D
S
V
HSF
I
QE
G
ESK
G
-
QL
L
LD
G
R
--
N--A
G
--
-
-
L
A
V
AIG
PT
I
IVDVDPNAS
L
SR
EE
I
FGPVL
V
V
TRFTSE
E
Q
A
L
QL
ANDSQYGL
G
A
A
V
W
T
R
DL
SR
A
H
R
M
S
RR
LK
A
G
SV
F
VN
NYNDGDMTV
P
F
GG
Y
K
Q
SG
N
G
RDK
S
LHA
L
EK
F
TEL
K
T
I
W
I
S
L
EA
fig|562.373.peg.5224
Escherichia coli 1125A
MNFHHLAYWQDKA
L
S
LAI
E
NR
L
F
ING
EYTAAAEN
---
ETFETV
D
P
V
T
QAP
L
ANIAR
G
KSV
D
I
D
R
AV
S
AA
RGV
F
ERGD
W
SLSS
P
AK
R
KAV
L
N
K
LA
D
L
IE
ANAE
E
L
A
L
LE
TL
D
T
GK
PIRHSLRD
D
I
PGAARAIR
W
Y
A
E
AIDKVY
G
EVATTS
---
---SHELAMIV
R
E
P
V
GV
I
A
A
I
V
PWNFP
LL
L
TC
WK
LG
PALAAGN
S
VV
L
KPSE
K
S
PL
S
A
I
RL
A
G
L
AK
EAG
L
P
D
GV
L
NVV
T
G
F
G
HEA
G
QA
L
S
R
H
N
D
I
DA
IA
F
TGS
TR
TGK
Q
L
LKD
A
G
D
S
N
M
KRV
W
LE
A
GGKS
A
N
IV
FA
D
CP
D
-----
L
Q
Q
A
ASATAAGIFY
N
Q
GQVC
IAGT
R
L
LLEESIA
D
E
F
LALLKQQAQNW
Q
P
G
HPLDPA
-
TTM
G
T
L
I
D
C
AH
A
D
S
V
HSF
I
QE
G
ESK
G
-
QL
L
LD
G
R
--
N--A
G
--
-
-
L
A
V
AIG
PT
I
IVDVDPNAS
L
SR
EE
I
FGPVL
V
V
TRFTSE
E
Q
A
L
QL
ANDSQYGL
G
A
A
V
W
T
R
DL
SR
A
H
R
M
S
RR
LK
A
G
SV
F
VN
NYNDGDMTV
P
F
GG
Y
K
Q
SG
N
G
RDK
S
LHA
L
EK
F
TEL
K
T
I
W
I
S
L
EA
fig|562.372.peg.853
Escherichia coli 1212A
MNFHHLAYWQDKA
L
S
LAI
E
NR
L
F
ING
EYTAAAEN
---
ETFETV
D
P
V
T
QAP
L
ANIAR
G
KSV
D
I
D
R
AV
S
AA
RGV
F
ERGD
W
SLSS
P
AK
R
KAV
L
N
K
LA
D
L
IE
ANAE
E
L
A
L
LE
TL
D
T
GK
PIRHSLRD
D
I
PGAARAIR
W
Y
A
E
AIDKVY
G
EVATTS
---
---SHELAMIV
R
E
P
V
GV
I
A
A
I
V
PWNFP
LL
L
TC
WK
LG
PALAAGN
S
VV
L
KPSE
K
S
PL
S
A
I
RL
A
G
L
AK
EAG
L
P
D
GV
L
NVV
T
G
F
G
HEA
G
QA
L
S
R
H
N
D
I
DA
IA
F
TGS
TR
TGK
Q
L
LKD
A
G
D
S
N
M
KRV
W
LE
A
GGKS
A
N
IV
FA
D
CP
D
-----
L
Q
Q
A
ASATAAGIFY
N
Q
GQVC
IAGT
R
L
LLEESIA
D
E
F
LALLKQQAQNW
Q
P
G
HPLDPA
-
TTM
G
T
L
I
D
C
AH
A
D
S
V
HSF
I
QE
G
ESK
G
-
QL
L
LD
G
R
--
N--A
G
--
-
-
L
A
V
AIG
PT
I
IVDVDPNAS
L
SR
EE
I
FGPVL
V
V
TRFTSE
E
Q
A
L
QL
ANDSQYGL
G
A
A
V
W
T
R
DL
SR
A
H
R
M
S
RR
LK
A
G
SV
F
VN
NYNDGDMTV
P
F
GG
Y
K
Q
SG
N
G
RDK
S
LHA
L
EK
F
TEL
K
T
I
W
I
S
L
EA
fig|562.374.peg.6079
Escherichia coli 536A
MNFHHLAYWQDKA
L
S
LAI
E
NR
L
F
ING
EYTAAAEN
---
ETFETV
D
P
V
T
QAP
L
ANIAR
G
KSV
D
I
D
R
AV
S
AA
RGV
F
ERGD
W
SLSS
P
AK
R
KAV
L
N
K
LA
D
L
IE
ANAE
E
L
A
L
LE
TL
D
T
GK
PIRHSLRD
D
I
PGAARAIR
W
Y
A
E
AIDKVY
G
EVATTS
---
---SHELAMIV
R
E
P
V
GV
I
A
A
I
V
PWNFP
LL
L
TC
WK
LG
PALAAGN
S
VV
L
KPSE
K
S
PL
S
A
I
RL
A
G
L
AK
EAG
L
P
D
GV
L
NVV
T
G
F
G
HEA
G
QA
L
S
R
H
N
D
I
DA
IA
F
TGS
TR
TGK
Q
L
LKD
A
G
D
S
N
M
KRV
W
LE
A
GGKS
A
N
IV
FA
D
CP
D
-----
L
Q
Q
A
ASATAAGIFY
N
Q
GQVC
IAGT
R
L
LLEESIA
D
E
F
LALLKQQAQNW
Q
P
G
HPLDPA
-
TTM
G
T
L
I
D
C
AH
A
D
S
V
HSF
I
QE
G
ESK
G
-
QL
L
LD
G
R
--
N--A
G
--
-
-
L
A
V
AIG
PT
I
IVDVDPNAS
L
SR
EE
I
FGPVL
V
V
TRFTSE
E
Q
A
L
QL
ANDSQYGL
G
A
A
V
W
T
R
DL
SR
A
H
R
M
S
RR
LK
A
G
SV
F
VN
NYNDGDMTV
P
F
GG
Y
K
Q
SG
N
G
RDK
S
LHA
L
EK
F
TEL
K
T
I
W
I
S
L
EA
fig|83334.1.peg.1912
Escherichia coli O157:H7
MNFHHLAYWQDKA
L
S
LAI
E
NR
L
F
ING
EYTAAAEN
---
ETFETV
D
P
V
T
QAP
L
ANIAR
G
KSV
D
I
D
R
AV
S
AA
RGV
F
ERGD
W
SLSS
P
AK
R
KAV
L
N
K
LA
D
L
IE
ANAE
E
L
A
L
LE
TL
D
T
GK
PIRHSLRD
D
I
PGAARAIR
W
Y
A
E
AIDKVY
G
EVATTS
---
---SHELAMIV
R
E
P
V
GV
I
A
A
I
V
PWNFP
LL
L
TC
WK
LG
PALAAGN
S
VV
L
KPSE
K
S
PL
S
A
I
RL
A
G
L
AK
EAG
L
P
D
GV
L
NVV
T
G
F
G
HEA
G
QA
L
S
R
H
N
D
I
DA
IA
F
TGS
TR
TGK
Q
L
LKD
A
G
D
S
N
M
KRV
W
LE
A
GGKS
A
N
IV
FA
D
CP
D
-----
L
Q
Q
A
ASATAAGIFY
N
Q
GQVC
IAGT
R
L
LLEESIA
D
E
F
LALLKQQAQNW
Q
P
G
HPLDPA
-
TTM
G
T
L
I
D
C
AH
A
D
S
V
HSF
I
QE
G
ESK
G
-
QL
L
LD
G
R
--
N--A
G
--
-
-
L
A
V
AIG
PT
I
IVDVDPNAS
L
SR
EE
I
FGPVL
V
V
TRFTSE
E
Q
A
L
QL
ANDSQYGL
G
A
A
V
W
T
R
DL
SR
A
H
R
M
S
RR
LK
A
G
SV
F
VN
NYNDGDMTV
P
F
GG
Y
K
Q
SG
N
G
RDK
S
LHA
L
EK
F
TEL
K
T
I
W
I
S
L
EA
fig|155864.1.peg.2196
Escherichia coli O157:H7 EDL933
MNFHHLAYWQDKA
L
S
LAI
E
NR
L
F
ING
EYTAAAEN
---
ETFETV
D
P
V
T
QAP
L
ANIAR
G
KSV
D
I
D
R
AV
S
AA
RGV
F
ERGD
W
SLSS
P
AK
R
KAV
L
N
K
LA
D
L
IE
ANAE
E
L
A
L
LE
TL
D
T
GK
PIRHSLRD
D
I
PGAARAIR
W
Y
A
E
AIDKVY
G
EVATTS
---
---SHELAMIV
R
E
P
V
GV
I
A
A
I
V
PWNFP
LL
L
TC
WK
LG
PALAAGN
S
VV
L
KPSE
K
S
PL
S
A
I
RL
A
G
L
AK
EAG
L
P
D
GV
L
NVV
T
G
F
G
HEA
G
QA
L
S
R
H
N
D
I
DA
IA
F
TGS
TR
TGK
Q
L
LKD
A
G
D
S
N
M
KRV
W
LE
A
GGKS
A
N
IV
FA
D
CP
D
-----
L
Q
Q
A
ASATAAGIFY
N
Q
GQVC
IAGT
R
L
LLEESIA
D
E
F
LALLKQQAQNW
Q
P
G
HPLDPA
-
TTM
G
T
L
I
D
C
AH
A
D
S
V
HSF
I
QE
G
ESK
G
-
QL
L
LD
G
R
--
N--A
G
--
-
-
L
A
V
AIG
PT
I
IVDVDPNAS
L
SR
EE
I
FGPVL
V
V
TRFTSE
E
Q
A
L
QL
ANDSQYGL
G
A
A
V
W
T
R
DL
SR
A
H
R
M
S
RR
LK
A
G
SV
F
VN
NYNDGDMTV
P
F
GG
Y
K
Q
SG
N
G
RDK
S
LHA
L
EK
F
TEL
K
T
I
W
I
S
L
EA
fig|155864.8.peg.2031
Escherichia coli O157:H7 EDL933
MNFHHLAYWQDKA
L
S
LAI
E
NR
L
F
ING
EYTAAAEN
---
ETFETV
D
P
V
T
QAP
L
ANIAR
G
KSV
D
I
D
R
AV
S
AA
RGV
F
ERGD
W
SLSS
P
AK
R
KAV
L
N
K
LA
D
L
IE
ANAE
E
L
A
L
LE
TL
D
T
GK
PIRHSLRD
D
I
PGAARAIR
W
Y
A
E
AIDKVY
G
EVATTS
---
---SHELAMIV
R
E
P
V
GV
I
A
A
I
V
PWNFP
LL
L
TC
WK
LG
PALAAGN
S
VV
L
KPSE
K
S
PL
S
A
I
RL
A
G
L
AK
EAG
L
P
D
GV
L
NVV
T
G
F
G
HEA
G
QA
L
S
R
H
N
D
I
DA
IA
F
TGS
TR
TGK
Q
L
LKD
A
G
D
S
N
M
KRV
W
LE
A
GGKS
A
N
IV
FA
D
CP
D
-----
L
Q
Q
A
ASATAAGIFY
N
Q
GQVC
IAGT
R
L
LLEESIA
D
E
F
LALLKQQAQNW
Q
P
G
HPLDPA
-
TTM
G
T
L
I
D
C
AH
A
D
S
V
HSF
I
QE
G
ESK
G
-
QL
L
LD
G
R
--
N--A
G
--
-
-
L
A
V
AIG
PT
I
IVDVDPNAS
L
SR
EE
I
FGPVL
V
V
TRFTSE
E
Q
A
L
QL
ANDSQYGL
G
A
A
V
W
T
R
DL
SR
A
H
R
M
S
RR
LK
A
G
SV
F
VN
NYNDGDMTV
P
F
GG
Y
K
Q
SG
N
G
RDK
S
LHA
L
EK
F
TEL
K
T
I
W
I
S
L
EA
fig|444454.5.peg.275
Escherichia coli O157:H7 str. EC4024
MNFHHLAYWQDKA
L
S
LAI
E
NR
L
F
ING
EYTAAAEN
---
ETFETV
D
P
V
T
QAP
L
ANIAR
G
KSV
D
I
D
R
AV
S
AA
RGV
F
ERGD
W
SLSS
P
AK
R
KAV
L
N
K
LA
D
L
IE
ANAE
E
L
A
L
LE
TL
D
T
GK
PIRHSLRD
D
I
PGAARAIR
W
Y
A
E
AIDKVY
G
EVATTS
---
---SHELAMIV
R
E
P
V
GV
I
A
A
I
V
PWNFP
LL
L
TC
WK
LG
PALAAGN
S
VV
L
KPSE
K
S
PL
S
A
I
RL
A
G
L
AK
EAG
L
P
D
GV
L
NVV
T
G
F
G
HEA
G
QA
L
S
R
H
N
D
I
DA
IA
F
TGS
TR
TGK
Q
L
LKD
A
G
D
S
N
M
KRV
W
LE
A
GGKS
A
N
IV
FA
D
CP
D
-----
L
Q
Q
A
ASATAAGIFY
N
Q
GQVC
IAGT
R
L
LLEESIA
D
E
F
LALLKQQAQNW
Q
P
G
HPLDPA
-
TTM
G
T
L
I
D
C
AH
A
D
S
V
HSF
I
QE
G
ESK
G
-
QL
L
LD
G
R
--
N--A
G
--
-
-
L
A
V
AIG
PT
I
IVDVDPNAS
L
SR
EE
I
FGPVL
V
V
TRFTSE
E
Q
A
L
QL
ANDSQYGL
G
A
A
V
W
T
R
DL
SR
A
H
R
M
S
RR
LK
A
G
SV
F
VN
NYNDGDMTV
P
F
GG
Y
K
Q
SG
N
G
RDK
S
LHA
L
EK
F
TEL
K
T
I
W
I
S
L
EA
fig|444449.5.peg.175
Escherichia coli O157:H7 str. EC4042
MNFHHLAYWQDKA
L
S
LAI
E
NR
L
F
ING
EYTAAAEN
---
ETFETV
D
P
V
T
QAP
L
ANIAR
G
KSV
D
I
D
R
AV
S
AA
RGV
F
ERGD
W
SLSS
P
AK
R
KAV
L
N
K
LA
D
L
IE
ANAE
E
L
A
L
LE
TL
D
T
GK
PIRHSLRD
D
I
PGAARAIR
W
Y
A
E
AIDKVY
G
EVATTS
---
---SHELAMIV
R
E
P
V
GV
I
A
A
I
V
PWNFP
LL
L
TC
WK
LG
PALAAGN
S
VV
L
KPSE
K
S
PL
S
A
I
RL
A
G
L
AK
EAG
L
P
D
GV
L
NVV
T
G
F
G
HEA
G
QA
L
S
R
H
N
D
I
DA
IA
F
TGS
TR
TGK
Q
L
LKD
A
G
D
S
N
M
KRV
W
LE
A
GGKS
A
N
IV
FA
D
CP
D
-----
L
Q
Q
A
ASATAAGIFY
N
Q
GQVC
IAGT
R
L
LLEESIA
D
E
F
LALLKQQAQNW
Q
P
G
HPLDPA
-
TTM
G
T
L
I
D
C
AH
A
D
S
V
HSF
I
QE
G
ESK
G
-
QL
L
LD
G
R
--
N--A
G
--
-
-
L
A
V
AIG
PT
I
IVDVDPNAS
L
SR
EE
I
FGPVL
V
V
TRFTSE
E
Q
A
L
QL
ANDSQYGL
G
A
A
V
W
T
R
DL
SR
A
H
R
M
S
RR
LK
A
G
SV
F
VN
NYNDGDMTV
P
F
GG
Y
K
Q
SG
N
G
RDK
S
LHA
L
EK
F
TEL
K
T
I
W
I
S
L
EA
fig|444448.5.peg.4531
Escherichia coli O157:H7 str. EC4045
MNFHHLAYWQDKA
L
S
LAI
E
NR
L
F
ING
EYTAAAEN
---
ETFETV
D
P
V
T
QAP
L
ANIAR
G
KSV
D
I
D
R
AV
S
AA
RGV
F
ERGD
W
SLSS
P
AK
R
KAV
L
N
K
LA
D
L
IE
ANAE
E
L
A
L
LE
TL
D
T
GK
PIRHSLRD
D
I
PGAARAIR
W
Y
A
E
AIDKVY
G
EVATTS
---
---SHELAMIV
R
E
P
V
GV
I
A
A
I
V
PWNFP
LL
L
TC
WK
LG
PALAAGN
S
VV
L
KPSE
K
S
PL
S
A
I
RL
A
G
L
AK
EAG
L
P
D
GV
L
NVV
T
G
F
G
HEA
G
QA
L
S
R
H
N
D
I
DA
IA
F
TGS
TR
TGK
Q
L
LKD
A
G
D
S
N
M
KRV
W
LE
A
GGKS
A
N
IV
FA
D
CP
D
-----
L
Q
Q
A
ASATAAGIFY
N
Q
GQVC
IAGT
R
L
LLEESIA
D
E
F
LALLKQQAQNW
Q
P
G
HPLDPA
-
TTM
G
T
L
I
D
C
AH
A
D
S
V
HSF
I
QE
G
ESK
G
-
QL
L
LD
G
R
--
N--A
G
--
-
-
L
A
V
AIG
PT
I
IVDVDPNAS
L
SR
EE
I
FGPVL
V
V
TRFTSE
E
Q
A
L
QL
ANDSQYGL
G
A
A
V
W
T
R
DL
SR
A
H
R
M
S
RR
LK
A
G
SV
F
VN
NYNDGDMTV
P
F
GG
Y
K
Q
SG
N
G
RDK
S
LHA
L
EK
F
TEL
K
T
I
W
I
S
L
EA
fig|444453.5.peg.4140
Escherichia coli O157:H7 str. EC4076
MNFHHLAYWQDKA
L
S
LAI
E
NR
L
F
ING
EYTAAAEN
---
ETFETV
D
P
V
T
QAP
L
ANIAR
G
KSV
D
I
D
R
AV
S
AA
RGV
F
ERGD
W
SLSS
P
AK
R
KAV
L
N
K
LA
D
L
IE
ANAE
E
L
A
L
LE
TL
D
T
GK
PIRHSLRD
D
I
PGAARAIR
W
Y
A
E
AIDKVY
G
EVATTS
---
---SHELAMIV
R
E
P
V
GV
I
A
A
I
V
PWNFP
LL
L
TC
WK
LG
PALAAGN
S
VV
L
KPSE
K
S
PL
S
A
I
RL
A
G
L
AK
EAG
L
P
D
GV
L
NVV
T
G
F
G
HEA
G
QA
L
S
R
H
N
D
I
DA
IA
F
TGS
TR
TGK
Q
L
LKD
A
G
D
S
N
M
KRV
W
LE
A
GGKS
A
N
IV
FA
D
CP
D
-----
L
Q
Q
A
ASATAAGIFY
N
Q
GQVC
IAGT
R
L
LLEESIA
D
E
F
LALLKQQAQNW
Q
P
G
HPLDPA
-
TTM
G
T
L
I
D
C
AH
A
D
S
V
HSF
I
QE
G
ESK
G
-
QL
L
LD
G
R
--
N--A
G
--
-
-
L
A
V
AIG
PT
I
IVDVDPNAS
L
SR
EE
I
FGPVL
V
V
TRFTSE
E
Q
A
L
QL
ANDSQYGL
G
A
A
V
W
T
R
DL
SR
A
H
R
M
S
RR
LK
A
G
SV
F
VN
NYNDGDMTV
P
F
GG
Y
K
Q
SG
N
G
RDK
S
LHA
L
EK
F
TEL
K
T
I
W
I
S
L
EA
fig|444452.5.peg.2092
Escherichia coli O157:H7 str. EC4113
MNFHHLAYWQDKA
L
S
LAI
E
NR
L
F
ING
EYTAAAEN
---
ETFETV
D
P
V
T
QAP
L
ANIAR
G
KSV
D
I
D
R
AV
S
AA
RGV
F
ERGD
W
SLSS
P
AK
R
KAV
L
N
K
LA
D
L
IE
ANAE
E
L
A
L
LE
TL
D
T
GK
PIRHSLRD
D
I
PGAARAIR
W
Y
A
E
AIDKVY
G
EVATTS
---
---SHELAMIV
R
E
P
V
GV
I
A
A
I
V
PWNFP
LL
L
TC
WK
LG
PALAAGN
S
VV
L
KPSE
K
S
PL
S
A
I
RL
A
G
L
AK
EAG
L
P
D
GV
L
NVV
T
G
F
G
HEA
G
QA
L
S
R
H
N
D
I
DA
IA
F
TGS
TR
TGK
Q
L
LKD
A
G
D
S
N
M
KRV
W
LE
A
GGKS
A
N
IV
FA
D
CP
D
-----
L
Q
Q
A
ASATAAGIFY
N
Q
GQVC
IAGT
R
L
LLEESIA
D
E
F
LALLKQQAQNW
Q
P
G
HPLDPA
-
TTM
G
T
L
I
D
C
AH
A
D
S
V
HSF
I
QE
G
ESK
G
-
QL
L
LD
G
R
--
N--A
G
--
-
-
L
A
V
AIG
PT
I
IVDVDPNAS
L
SR
EE
I
FGPVL
V
V
TRFTSE
E
Q
A
L
QL
ANDSQYGL
G
A
A
V
W
T
R
DL
SR
A
H
R
M
S
RR
LK
A
G
SV
F
VN
NYNDGDMTV
P
F
GG
Y
K
Q
SG
N
G
RDK
S
LHA
L
EK
F
TEL
K
T
I
W
I
S
L
EA
fig|444450.8.peg.1993
Escherichia coli O157:H7 str. EC4115
MNFHHLAYWQDKA
L
S
LAI
E
NR
L
F
ING
EYTAAAEN
---
ETFETV
D
P
V
T
QAP
L
ANIAR
G
KSV
D
I
D
R
AV
S
AA
RGV
F
ERGD
W
SLSS
P
AK
R
KAV
L
N
K
LA
D
L
IE
ANAE
E
L
A
L
LE
TL
D
T
GK
PIRHSLRD
D
I
PGAARAIR
W
Y
A
E
AIDKVY
G
EVATTS
---
---SHELAMIV
R
E
P
V
GV
I
A
A
I
V
PWNFP
LL
L
TC
WK
LG
PALAAGN
S
VV
L
KPSE
K
S
PL
S
A
I
RL
A
G
L
AK
EAG
L
P
D
GV
L
NVV
T
G
F
G
HEA
G
QA
L
S
R
H
N
D
I
DA
IA
F
TGS
TR
TGK
Q
L
LKD
A
G
D
S
N
M
KRV
W
LE
A
GGKS
A
N
IV
FA
D
CP
D
-----
L
Q
Q
A
ASATAAGIFY
N
Q
GQVC
IAGT
R
L
LLEESIA
D
E
F
LALLKQQAQNW
Q
P
G
HPLDPA
-
TTM
G
T
L
I
D
C
AH
A
D
S
V
HSF
I
QE
G
ESK
G
-
QL
L
LD
G
R
--
N--A
G
--
-
-
L
A
V
AIG
PT
I
IVDVDPNAS
L
SR
EE
I
FGPVL
V
V
TRFTSE
E
Q
A
L
QL
ANDSQYGL
G
A
A
V
W
T
R
DL
SR
A
H
R
M
S
RR
LK
A
G
SV
F
VN
NYNDGDMTV
P
F
GG
Y
K
Q
SG
N
G
RDK
S
LHA
L
EK
F
TEL
K
T
I
W
I
S
L
EA
fig|444451.5.peg.2738
Escherichia coli O157:H7 str. EC4196
MNFHHLAYWQDKA
L
S
LAI
E
NR
L
F
ING
EYTAAAEN
---
ETFETV
D
P
V
T
QAP
L
ANIAR
G
KSV
D
I
D
R
AV
S
AA
RGV
F
ERGD
W
SLSS
P
AK
R
KAV
L
N
K
LA
D
L
IE
ANAE
E
L
A
L
LE
TL
D
T
GK
PIRHSLRD
D
I
PGAARAIR
W
Y
A
E
AIDKVY
G
EVATTS
---
---SHELAMIV
R
E
P
V
GV
I
A
A
I
V
PWNFP
LL
L
TC
WK
LG
PALAAGN
S
VV
L
KPSE
K
S
PL
S
A
I
RL
A
G
L
AK
EAG
L
P
D
GV
L
NVV
T
G
F
G
HEA
G
QA
L
S
R
H
N
D
I
DA
IA
F
TGS
TR
TGK
Q
L
LKD
A
G
D
S
N
M
KRV
W
LE
A
GGKS
A
N
IV
FA
D
CP
D
-----
L
Q
Q
A
ASATAAGIFY
N
Q
GQVC
IAGT
R
L
LLEESIA
D
E
F
LALLKQQAQNW
Q
P
G
HPLDPA
-
TTM
G
T
L
I
D
C
AH
A
D
S
V
HSF
I
QE
G
ESK
G
-
QL
L
LD
G
R
--
N--A
G
--
-
-
L
A
V
AIG
PT
I
IVDVDPNAS
L
SR
EE
I
FGPVL
V
V
TRFTSE
E
Q
A
L
QL
ANDSQYGL
G
A
A
V
W
T
R
DL
SR
A
H
R
M
S
RR
LK
A
G
SV
F
VN
NYNDGDMTV
P
F
GG
Y
K
Q
SG
N
G
RDK
S
LHA
L
EK
F
TEL
K
T
I
W
I
S
L
EA
fig|444447.5.peg.5440
Escherichia coli O157:H7 str. EC4206
MNFHHLAYWQDKA
L
S
LAI
E
NR
L
F
ING
EYTAAAEN
---
ETFETV
D
P
V
T
QAP
L
ANIAR
G
KSV
D
I
D
R
AV
S
AA
RGV
F
ERGD
W
SLSS
P
AK
R
KAV
L
N
K
LA
D
L
IE
ANAE
E
L
A
L
LE
TL
D
T
GK
PIRHSLRD
D
I
PGAARAIR
W
Y
A
E
AIDKVY
G
EVATTS
---
---SHELAMIV
R
E
P
V
GV
I
A
A
I
V
PWNFP
LL
L
TC
WK
LG
PALAAGN
S
VV
L
KPSE
K
S
PL
S
A
I
RL
A
G
L
AK
EAG
L
P
D
GV
L
NVV
T
G
F
G
HEA
G
QA
L
S
R
H
N
D
I
DA
IA
F
TGS
TR
TGK
Q
L
LKD
A
G
D
S
N
M
KRV
W
LE
A
GGKS
A
N
IV
FA
D
CP
D
-----
L
Q
Q
A
ASATAAGIFY
N
Q
GQVC
IAGT
R
L
LLEESIA
D
E
F
LALLKQQAQNW
Q
P
G
HPLDPA
-
TTM
G
T
L
I
D
C
AH
A
D
S
V
HSF
I
QE
G
ESK
G
-
QL
L
LD
G
R
--
N--A
G
--
-
-
L
A
V
AIG
PT
I
IVDVDPNAS
L
SR
EE
I
FGPVL
V
V
TRFTSE
E
Q
A
L
QL
ANDSQYGL
G
A
A
V
W
T
R
DL
SR
A
H
R
M
S
RR
LK
A
G
SV
F
VN
NYNDGDMTV
P
F
GG
Y
K
Q
SG
N
G
RDK
S
LHA
L
EK
F
TEL
K
T
I
W
I
S
L
EA
fig|478004.5.peg.2722
Escherichia coli O157:H7 str. EC4401
MNFHHLAYWQDKA
L
S
LAI
E
NR
L
F
ING
EYTAAAEN
---
ETFETV
D
P
V
T
QAP
L
ANIAR
G
KSV
D
I
D
R
AV
S
AA
RGV
F
ERGD
W
SLSS
P
AK
R
KAV
L
N
K
LA
D
L
IE
ANAE
E
L
A
L
LE
TL
D
T
GK
PIRHSLRD
D
I
PGAARAIR
W
Y
A
E
AIDKVY
G
EVATTS
---
---SHELAMIV
R
E
P
V
GV
I
A
A
I
V
PWNFP
LL
L
TC
WK
LG
PALAAGN
S
VV
L
KPSE
K
S
PL
S
A
I
RL
A
G
L
AK
EAG
L
P
D
GV
L
NVV
T
G
F
G
HEA
G
QA
L
S
R
H
N
D
I
DA
IA
F
TGS
TR
TGK
Q
L
LKD
A
G
D
S
N
M
KRV
W
LE
A
GGKS
A
N
IV
FA
D
CP
D
-----
L
Q
Q
A
ASATAAGIFY
N
Q
GQVC
IAGT
R
L
LLEESIA
D
E
F
LALLKQQAQNW
Q
P
G
HPLDPA
-
TTM
G
T
L
I
D
C
AH
A
D
S
V
HSF
I
QE
G
ESK
G
-
QL
L
LD
G
R
--
N--A
G
--
-
-
L
A
V
AIG
PT
I
IVDVDPNAS
L
SR
EE
I
FGPVL
V
V
TRFTSE
E
Q
A
L
QL
ANDSQYGL
G
A
A
V
W
T
R
DL
SR
A
H
R
M
S
RR
LK
A
G
SV
F
VN
NYNDGDMTV
P
F
GG
Y
K
Q
SG
N
G
RDK
S
LHA
L
EK
F
TEL
K
T
I
W
I
S
L
EA
fig|478005.5.peg.3303
Escherichia coli O157:H7 str. EC4486
MNFHHLAYWQDKA
L
S
LAI
E
NR
L
F
ING
EYTAAAEN
---
ETFETV
D
P
V
T
QAP
L
ANIAR
G
KSV
D
I
D
R
AV
S
AA
RGV
F
ERGD
W
SLSS
P
AK
R
KAV
L
N
K
LA
D
L
IE
ANAE
E
L
A
L
LE
TL
D
T
GK
PIRHSLRD
D
I
PGAARAIR
W
Y
A
E
AIDKVY
G
EVATTS
---
---SHELAMIV
R
E
P
V
GV
I
A
A
I
V
PWNFP
LL
L
TC
WK
LG
PALAAGN
S
VV
L
KPSE
K
S
PL
S
A
I
RL
A
G
L
AK
EAG
L
P
D
GV
L
NVV
T
G
F
G
HEA
G
QA
L
S
R
H
N
D
I
DA
IA
F
TGS
TR
TGK
Q
L
LKD
A
G
D
S
N
M
KRV
W
LE
A
GGKS
A
N
IV
FA
D
CP
D
-----
L
Q
Q
A
ASATAAGIFY
N
Q
GQVC
IAGT
R
L
LLEESIA
D
E
F
LALLKQQAQNW
Q
P
G
HPLDPA
-
TTM
G
T
L
I
D
C
AH
A
D
S
V
HSF
I
QE
G
ESK
G
-
QL
L
LD
G
R
--
N--A
G
--
-
-
L
A
V
AIG
PT
I
IVDVDPNAS
L
SR
EE
I
FGPVL
V
V
TRFTSE
E
Q
A
L
QL
ANDSQYGL
G
A
A
V
W
T
R
DL
SR
A
H
R
M
S
RR
LK
A
G
SV
F
VN
NYNDGDMTV
P
F
GG
Y
K
Q
SG
N
G
RDK
S
LHA
L
EK
F
TEL
K
T
I
W
I
S
L
EA
fig|478006.5.peg.3124
Escherichia coli O157:H7 str. EC4501
MNFHHLAYWQDKA
L
S
LAI
E
NR
L
F
ING
EYTAAAEN
---
ETFETV
D
P
V
T
QAP
L
ANIAR
G
KSV
D
I
D
R
AV
S
AA
RGV
F
ERGD
W
SLSS
P
AK
R
KAV
L
N
K
LA
D
L
IE
ANAE
E
L
A
L
LE
TL
D
T
GK
PIRHSLRD
D
I
PGAARAIR
W
Y
A
E
AIDKVY
G
EVATTS
---
---SHELAMIV
R
E
P
V
GV
I
A
A
I
V
PWNFP
LL
L
TC
WK
LG
PALAAGN
S
VV
L
KPSE
K
S
PL
S
A
I
RL
A
G
L
AK
EAG
L
P
D
GV
L
NVV
T
G
F
G
HEA
G
QA
L
S
R
H
N
D
I
DA
IA
F
TGS
TR
TGK
Q
L
LKD
A
G
D
S
N
M
KRV
W
LE
A
GGKS
A
N
IV
FA
D
CP
D
-----
L
Q
Q
A
ASATAAGIFY
N
Q
GQVC
IAGT
R
L
LLEESIA
D
E
F
LALLKQQAQNW
Q
P
G
HPLDPA
-
TTM
G
T
L
I
D
C
AH
A
D
S
V
HSF
I
QE
G
ESK
G
-
QL
L
LD
G
R
--
N--A
G
--
-
-
L
A
V
AIG
PT
I
IVDVDPNAS
L
SR
EE
I
FGPVL
V
V
TRFTSE
E
Q
A
L
QL
ANDSQYGL
G
A
A
V
W
T
R
DL
SR
A
H
R
M
S
RR
LK
A
G
SV
F
VN
NYNDGDMTV
P
F
GG
Y
K
Q
SG
N
G
RDK
S
LHA
L
EK
F
TEL
K
T
I
W
I
S
L
EA
fig|478007.5.peg.2341
Escherichia coli O157:H7 str. EC508
MNFHHLAYWQDKA
L
S
LAI
E
NR
L
F
ING
EYTAAAEN
---
ETFETV
D
P
V
T
QAP
L
ANIAR
G
KSV
D
I
D
R
AV
S
AA
RGV
F
ERGD
W
SLSS
P
AK
R
KAV
L
N
K
LA
D
L
IE
ANAE
E
L
A
L
LE
TL
D
T
GK
PIRHSLRD
D
I
PGAARAIR
W
Y
A
E
AIDKVY
G
EVATTS
---
---SHELAMIV
R
E
P
V
GV
I
A
A
I
V
PWNFP
LL
L
TC
WK
LG
PALAAGN
S
VV
L
KPSE
K
S
PL
S
A
I
RL
A
G
L
AK
EAG
L
P
D
GV
L
NVV
T
G
F
G
HEA
G
QA
L
S
R
H
N
D
I
DA
IA
F
TGS
TR
TGK
Q
L
LKD
A
G
D
S
N
M
KRV
W
LE
A
GGKS
A
N
IV
FA
D
CP
D
-----
L
Q
Q
A
ASATAAGIFY
N
Q
GQVC
IAGT
R
L
LLEESIA
D
E
F
LALLKQQAQNW
Q
P
G
HPLDPA
-
TTM
G
T
L
I
D
C
AH
A
D
S
V
HSF
I
QE
G
ESK
G
-
QL
L
LD
G
R
--
N--A
G
--
-
-
L
A
V
AIG
PT
I
IVDVDPNAS
L
SR
EE
I
FGPVL
V
V
TRFTSE
E
Q
A
L
QL
ANDSQYGL
G
A
A
V
W
T
R
DL
SR
A
H
R
M
S
RR
LK
A
G
SV
F
VN
NYNDGDMTV
P
F
GG
Y
K
Q
SG
N
G
RDK
S
LHA
L
EK
F
TEL
K
T
I
W
I
S
L
EA
fig|478008.5.peg.3565
Escherichia coli O157:H7 str. EC869
MNFHHLAYWQDKA
L
S
LAI
E
NR
L
F
ING
EYTAAAEN
---
ETFETV
D
P
V
T
QAP
L
ANIAR
G
KSV
D
I
D
R
AV
S
AA
RGV
F
ERGD
W
SLSS
P
AK
R
KAV
L
N
K
LA
D
L
IE
ANAE
E
L
A
L
LE
TL
D
T
GK
PIRHSLRD
D
I
PGAARAIR
W
Y
A
E
AIDKVY
G
EVATTS
---
---SHELAMIV
R
E
P
V
GV
I
A
A
I
V
PWNFP
LL
L
TC
WK
LG
PALAAGN
S
VV
L
KPSE
K
S
PL
S
A
I
RL
A
G
L
AK
EAG
L
P
D
GV
L
NVV
T
G
F
G
HEA
G
QA
L
S
R
H
N
D
I
DA
IA
F
TGS
TR
TGK
Q
L
LKD
A
G
D
S
N
M
KRV
W
LE
A
GGKS
A
N
IV
FA
D
CP
D
-----
L
Q
Q
A
ASATAAGIFY
N
Q
GQVC
IAGT
R
L
LLEESIA
D
E
F
LALLKQQAQNW
Q
P
G
HPLDPA
-
TTM
G
T
L
I
D
C
AH
A
D
S
V
HSF
I
QE
G
ESK
G
-
QL
L
LD
G
R
--
N--A
G
--
-
-
L
A
V
AIG
PT
I
IVDVDPNAS
L
SR
EE
I
FGPVL
V
V
TRFTSE
E
Q
A
L
QL
ANDSQYGL
G
A
A
V
W
T
R
DL
SR
A
H
R
M
S
RR
LK
A
G
SV
F
VN
NYNDGDMTV
P
F
GG
Y
K
Q
SG
N
G
RDK
S
LHA
L
EK
F
TEL
K
T
I
W
I
S
L
EA
fig|637388.3.peg.1365
Escherichia coli O157:H7 str. FRIK2000
MNFHHLAYWQDKA
L
S
LAI
E
NR
L
F
ING
EYTAAAEN
---
ETFETV
D
P
V
T
QAP
L
ANIAR
G
KSV
D
I
D
R
AV
S
AA
RGV
F
ERGD
W
SLSS
P
AK
R
KAV
L
N
K
LA
D
L
IE
ANAE
E
L
A
L
LE
TL
D
T
GK
PIRHSLRD
D
I
PGAARAIR
W
Y
A
E
AIDKVY
G
EVATTS
---
---SHELAMIV
R
E
P
V
GV
I
A
A
I
V
PWNFP
LL
L
TC
WK
LG
PALAAGN
S
VV
L
KPSE
K
S
PL
S
A
I
RL
A
G
L
AK
EAG
L
P
D
GV
L
NVV
T
G
F
G
HEA
G
QA
L
S
R
H
N
D
I
DA
IA
F
TGS
TR
TGK
Q
L
LKD
A
G
D
S
N
M
KRV
W
LE
A
GGKS
A
N
IV
FA
D
CP
D
-----
L
Q
Q
A
ASATAAGIFY
N
Q
GQVC
IAGT
R
L
LLEESIA
D
E
F
LALLKQQAQNW
Q
P
G
HPLDPA
-
TTM
G
T
L
I
D
C
AH
A
D
S
V
HSF
I
QE
G
ESK
G
-
QL
L
LD
G
R
--
N--A
G
--
-
-
L
A
V
AIG
PT
I
IVDVDPNAS
L
SR
EE
I
FGPVL
V
V
TRFTSE
E
Q
A
L
QL
ANDSQYGL
G
A
A
V
W
T
R
DL
SR
A
H
R
M
S
RR
LK
A
G
SV
F
VN
NYNDGDMTV
P
F
GG
Y
K
Q
SG
N
G
RDK
S
LHA
L
EK
F
TEL
K
T
I
W
I
S
L
EA
fig|570506.3.peg.3348
Escherichia coli O157:H7 str. FRIK966
MNFHHLAYWQDKA
L
S
LAI
E
NR
L
F
ING
EYTAAAEN
---
ETFETV
D
P
V
T
QAP
L
ANIAR
G
KSV
D
I
D
R
AV
S
AA
RGV
F
ERGD
W
SLSS
P
AK
R
KAV
L
N
K
LA
D
L
IE
ANAE
E
L
A
L
LE
TL
D
T
GK
PIRHSLRD
D
I
PGAARAIR
W
Y
A
E
AIDKVY
G
EVATTS
---
---SHELAMIV
R
E
P
V
GV
I
A
A
I
V
PWNFP
LL
L
TC
WK
LG
PALAAGN
S
VV
L
KPSE
K
S
PL
S
A
I
RL
A
G
L
AK
EAG
L
P
D
GV
L
NVV
T
G
F
G
HEA
G
QA
L
S
R
H
N
D
I
DA
IA
F
TGS
TR
TGK
Q
L
LKD
A
G
D
S
N
M
KRV
W
LE
A
GGKS
A
N
IV
FA
D
CP
D
-----
L
Q
Q
A
ASATAAGIFY
N
Q
GQVC
IAGT
R
L
LLEESIA
D
E
F
LALLKQQAQNW
Q
P
G
HPLDPA
-
TTM
G
T
L
I
D
C
AH
A
D
S
V
HSF
I
QE
G
ESK
G
-
QL
L
LD
G
R
--
N--A
G
--
-
-
L
A
V
AIG
PT
I
IVDVDPNAS
L
SR
EE
I
FGPVL
V
V
TRFTSE
E
Q
A
L
QL
ANDSQYGL
G
A
A
V
W
T
R
DL
SR
A
H
R
M
S
RR
LK
A
G
SV
F
VN
NYNDGDMTV
P
F
GG
Y
K
Q
SG
N
G
RDK
S
LHA
L
EK
F
TEL
K
T
I
W
I
S
L
EA
fig|386585.9.peg.1981
Escherichia coli O157:H7 str. Sakai
MNFHHLAYWQDKA
L
S
LAI
E
NR
L
F
ING
EYTAAAEN
---
ETFETV
D
P
V
T
QAP
L
ANIAR
G
KSV
D
I
D
R
AV
S
AA
RGV
F
ERGD
W
SLSS
P
AK
R
KAV
L
N
K
LA
D
L
IE
ANAE
E
L
A
L
LE
TL
D
T
GK
PIRHSLRD
D
I
PGAARAIR
W
Y
A
E
AIDKVY
G
EVATTS
---
---SHELAMIV
R
E
P
V
GV
I
A
A
I
V
PWNFP
LL
L
TC
WK
LG
PALAAGN
S
VV
L
KPSE
K
S
PL
S
A
I
RL
A
G
L
AK
EAG
L
P
D
GV
L
NVV
T
G
F
G
HEA
G
QA
L
S
R
H
N
D
I
DA
IA
F
TGS
TR
TGK
Q
L
LKD
A
G
D
S
N
M
KRV
W
LE
A
GGKS
A
N
IV
FA
D
CP
D
-----
L
Q
Q
A
ASATAAGIFY
N
Q
GQVC
IAGT
R
L
LLEESIA
D
E
F
LALLKQQAQNW
Q
P
G
HPLDPA
-
TTM
G
T
L
I
D
C
AH
A
D
S
V
HSF
I
QE
G
ESK
G
-
QL
L
LD
G
R
--
N--A
G
--
-
-
L
A
V
AIG
PT
I
IVDVDPNAS
L
SR
EE
I
FGPVL
V
V
TRFTSE
E
Q
A
L
QL
ANDSQYGL
G
A
A
V
W
T
R
DL
SR
A
H
R
M
S
RR
LK
A
G
SV
F
VN
NYNDGDMTV
P
F
GG
Y
K
Q
SG
N
G
RDK
S
LHA
L
EK
F
TEL
K
T
I
W
I
S
L
EA
fig|544404.4.peg.1854
Escherichia coli O157:H7 str. TW14359
MNFHHLAYWQDKA
L
S
LAI
E
NR
L
F
ING
EYTAAAEN
---
ETFETV
D
P
V
T
QAP
L
ANIAR
G
KSV
D
I
D
R
AV
S
AA
RGV
F
ERGD
W
SLSS
P
AK
R
KAV
L
N
K
LA
D
L
IE
ANAE
E
L
A
L
LE
TL
D
T
GK
PIRHSLRD
D
I
PGAARAIR
W
Y
A
E
AIDKVY
G
EVATTS
---
---SHELAMIV
R
E
P
V
GV
I
A
A
I
V
PWNFP
LL
L
TC
WK
LG
PALAAGN
S
VV
L
KPSE
K
S
PL
S
A
I
RL
A
G
L
AK
EAG
L
P
D
GV
L
NVV
T
G
F
G
HEA
G
QA
L
S
R
H
N
D
I
DA
IA
F
TGS
TR
TGK
Q
L
LKD
A
G
D
S
N
M
KRV
W
LE
A
GGKS
A
N
IV
FA
D
CP
D
-----
L
Q
Q
A
ASATAAGIFY
N
Q
GQVC
IAGT
R
L
LLEESIA
D
E
F
LALLKQQAQNW
Q
P
G
HPLDPA
-
TTM
G
T
L
I
D
C
AH
A
D
S
V
HSF
I
QE
G
ESK
G
-
QL
L
LD
G
R
--
N--A
G
--
-
-
L
A
V
AIG
PT
I
IVDVDPNAS
L
SR
EE
I
FGPVL
V
V
TRFTSE
E
Q
A
L
QL
ANDSQYGL
G
A
A
V
W
T
R
DL
SR
A
H
R
M
S
RR
LK
A
G
SV
F
VN
NYNDGDMTV
P
F
GG
Y
K
Q
SG
N
G
RDK
S
LHA
L
EK
F
TEL
K
T
I
W
I
S
L
EA
fig|502346.5.peg.5497
Escherichia coli O157:H7 str. TW14588
MNFHHLAYWQDKA
L
S
LAI
E
NR
L
F
ING
EYTAAAEN
---
ETFETV
D
P
V
T
QAP
L
ANIAR
G
KSV
D
I
D
R
AV
S
AA
RGV
F
ERGD
W
SLSS
P
AK
R
KAV
L
N
K
LA
D
L
IE
ANAE
E
L
A
L
LE
TL
D
T
GK
PIRHSLRD
D
I
PGAARAIR
W
Y
A
E
AIDKVY
G
EVATTS
---
---SHELAMIV
R
E
P
V
GV
I
A
A
I
V
PWNFP
LL
L
TC
WK
LG
PALAAGN
S
VV
L
KPSE
K
S
PL
S
A
I
RL
A
G
L
AK
EAG
L
P
D
GV
L
NVV
T
G
F
G
HEA
G
QA
L
S
R
H
N
D
I
DA
IA
F
TGS
TR
TGK
Q
L
LKD
A
G
D
S
N
M
KRV
W
LE
A
GGKS
A
N
IV
FA
D
CP
D
-----
L
Q
Q
A
ASATAAGIFY
N
Q
GQVC
IAGT
R
L
LLEESIA
D
E
F
LALLKQQAQNW
Q
P
G
HPLDPA
-
TTM
G
T
L
I
D
C
AH
A
D
S
V
HSF
I
QE
G
ESK
G
-
QL
L
LD
G
R
--
N--A
G
--
-
-
L
A
V
AIG
PT
I
IVDVDPNAS
L
SR
EE
I
FGPVL
V
V
TRFTSE
E
Q
A
L
QL
ANDSQYGL
G
A
A
V
W
T
R
DL
SR
A
H
R
M
S
RR
LK
A
G
SV
F
VN
NYNDGDMTV
P
F
GG
Y
K
Q
SG
N
G
RDK
S
LHA
L
EK
F
TEL
K
T
I
W
I
S
L
EA
fig|701177.3.peg.1639
Escherichia coli O55:H7 str. CB9615
MNFHHLAYWQDKA
L
S
LAI
E
NR
L
F
ING
EYTAAAEN
---
ETFETV
D
P
V
T
QAP
L
ANIAR
G
KSV
D
I
D
R
AV
S
AA
RGV
F
ERGD
W
SLSS
P
AK
R
KAV
L
N
K
LA
D
L
IE
ANAE
E
L
A
L
LE
TL
D
T
GK
PIRHSLRD
D
I
PGAARAIR
W
Y
A
E
AIDKVY
G
EVATTS
---
---SHELAMIV
R
E
P
V
GV
I
A
A
I
V
PWNFP
LL
L
TC
WK
LG
PALAAGN
S
VV
L
KPSE
K
S
PL
S
A
I
RL
A
G
L
AK
EAG
L
P
D
GV
L
NVV
T
G
F
G
HEA
G
QA
L
S
R
H
N
D
I
DA
IA
F
TGS
TR
TGK
Q
L
LKD
A
G
D
S
N
M
KRV
W
LE
A
GGKS
A
N
IV
FA
D
CP
D
-----
L
Q
Q
A
ASATAAGIFY
N
Q
GQVC
IAGT
R
L
LLEESIA
D
E
F
LALLKQQAQNW
Q
P
G
HPLDPA
-
TTM
G
T
L
I
D
C
AH
A
D
S
V
HSF
I
QE
G
ESK
G
-
QL
L
LD
G
R
--
N--A
G
--
-
-
L
A
V
AIG
PT
I
IVDVDPNAS
L
SR
EE
I
FGPVL
V
V
TRFTSE
E
Q
A
L
QL
ANDSQYGL
G
A
A
V
W
T
R
DL
SR
A
H
R
M
S
RR
LK
A
G
SV
F
VN
NYNDGDMTV
P
F
GG
Y
K
Q
SG
N
G
RDK
S
LHA
L
EK
F
TEL
K
T
I
W
I
S
L
EA
fig|550677.3.peg.2767
Escherichia coli B354
MNFHHLAYWQDKA
L
S
LAI
E
TR
L
F
ING
EYTAAAEN
---
ETFETV
D
P
V
T
QAP
L
AKIAR
G
KSV
D
I
D
R
AV
S
AA
RGV
F
ERGD
W
SLSS
P
AK
R
KAV
L
N
K
LA
D
L
M
E
ANAE
E
L
A
L
LE
TL
D
T
GK
PIRHSLRD
D
I
PGAARAIR
W
Y
A
E
AIDKVY
G
EVATTS
---
---SHELAMIV
R
E
P
V
GV
I
A
A
I
V
PWNFP
LL
L
TC
WK
LG
PALAAGN
S
V
I
L
KPSE
K
S
PL
S
A
I
RL
A
G
L
AK
EAG
L
P
D
GV
L
NVV
T
G
F
G
HEA
G
QA
L
S
R
H
N
D
I
DA
IA
F
TGS
TR
TGK
Q
L
LKD
A
G
D
S
N
M
KRV
W
LE
A
GGKS
A
N
IV
FA
D
CP
D
-----
L
Q
Q
A
ASATAAGIFY
N
Q
GQVC
IAGT
R
L
LLEESIA
D
K
F
LDLLKQQAQNW
Q
P
G
HPLDPA
-
TTM
G
T
L
I
D
C
AH
A
D
L
V
HSF
I
RE
G
EGE
G
-
QL
L
LD
G
R
--
N--A
E
--
-
-
L
AA
AIG
PT
I
FVDVDPNAS
L
SR
EE
I
FGPVL
V
V
TRFTSE
E
Q
A
L
QL
ANDSQYGL
G
A
A
V
W
T
R
DL
SR
A
H
R
M
S
RR
LK
A
G
SV
F
VN
NYNDGDMTV
P
F
GG
Y
K
Q
SG
N
G
RDK
S
LHA
L
EK
F
TEL
K
T
I
W
I
S
L
EA
fig|749538.3.peg.1868
Escherichia coli MS 116-1 (5-497/499)
H
V
A
VLSQVQ
Q
F
LDR
Q
HG
L
Y
I
D
G
RPGPAQSE
---
KRLAIF
D
PAT
GQE
I
ASTAD
A
NEA
D
V
D
N
AV
M
S
A
WRA
F
VSRR
W
AGRL
P
AE
R
ERI
L
L
R
FA
D
L
V
E
QHSE
E
L
A
Q
LE
TL
E
Q
GK
SIAISRAF
E
V
GCTLNWMR
Y
T
AG
LTTKIV
G
KTLDLS
IPL
PQGARYQAWTR
K
E
P
V
GV
V
A
G
I
V
PWNFP
LM
I
GM
WK
VM
PALAAG
C
S
I
V
I
KPSE
T
TPLT
M
L
RV
A
E
L
AS
EAG
I
P
D
GV
F
NVV
T
G
S
G
AVC
G
AA
LT
S
HP
H
V
AK
I
S
F
TGS
TA
TGK
G
I
ART
A
A
D
-
HL
T
RV
T
LELGGK
N
P
A
IV
LK
D
-
AD
-----
P
Q
W
V
IEGLMTGSFL
N
Q
GQVC
AASS
R
I
YIEAPLF
D
T
L
VSGFEQAVKSL
Q
V
G
PGMSPV
-
AQI
N
PL
V
S
R
AH
C
D
K
V
CSF
L
DD
A
QAQ
Q
-
AE
L
IR
G
S
--
NGPA
G
--
-
-
E
GY
YVA
PTL
VVNPDAKLR
L
TR
EE
V
FGPV
V
N
L
VRVADG
EEA
L
QL
AND
T
E
YGL
T
A
S
V
W
T
Q
N
L
SQ
A
L
E
Y
S
DR
L
Q
A
G
TV
WVN
SHTLIDANL
P
F
GG
M
K
Q
SG
T
G
RDF
G
PDW
L
DG
W
CET
K
S
V
C
V
fig|749544.3.peg.531
Escherichia coli MS 175-1 (5-497/499)
H
V
A
VLSQVQ
Q
F
LDR
Q
HG
L
Y
I
D
G
RPGPAQSE
---
KRLAIF
D
PAT
GQE
I
ASTAD
A
NEA
D
V
D
N
AV
M
S
A
WRA
F
VSRR
W
AGRL
P
AE
R
ERI
L
L
R
FA
D
L
V
E
QHSE
E
L
A
Q
LE
TL
E
Q
GK
SIAISRAF
E
V
GCTLNWMR
Y
T
AG
LTTKIV
G
KTLDLS
IPL
PQGARYQAWTR
K
E
P
V
GV
V
A
G
I
V
PWNFP
LM
I
GM
WK
VM
PALAAG
C
S
I
V
I
KPSE
T
TPLT
M
L
RV
A
E
L
AS
EAG
I
P
D
GV
F
NVV
T
G
S
G
AVC
G
AA
LT
S
HP
H
V
AK
I
S
F
TGS
TA
TGK
G
I
ART
A
A
D
-
HL
T
RV
T
LELGGK
N
P
A
IV
LK
D
-
AD
-----
P
Q
W
V
IEGLMTGSFL
N
Q
GQVC
AASS
R
I
YIEAPLF
D
T
L
VSGFEQAVKSL
Q
V
G
PGMSPV
-
AQI
N
PL
V
S
R
AH
C
D
K
V
CSF
L
DD
A
QAQ
Q
-
AE
L
IR
G
S
--
NGPA
G
--
-
-
E
GY
YVA
PTL
VVNPDAKLR
L
TR
EE
V
FGPV
V
N
L
VRVADG
EEA
L
QL
AND
T
E
YGL
T
A
S
V
W
T
Q
N
L
SQ
A
L
E
Y
S
DR
L
Q
A
G
TV
WVN
SHTLIDANL
P
F
GG
M
K
Q
SG
T
G
RDF
G
PDW
L
DG
W
CET
K
S
V
C
V
fig|316401.4.peg.1679
Escherichia coli ETEC H10407 (5-497/499)
H
V
A
VLSQVQ
Q
F
LDR
Q
HG
L
Y
I
D
G
RPGPAQSE
---
KRLAIF
D
PAT
GQE
I
ASTAD
A
NEA
D
V
D
N
AV
M
S
A
WRA
F
VSRR
W
AGRL
P
AE
R
ERI
L
L
R
FA
D
L
V
E
QHSE
E
L
A
Q
LE
TL
E
Q
GK
SIAISRAF
E
V
GCTLNWMR
Y
T
AG
LTTKIA
G
KTLDLS
IPL
PQGARYQAWTR
K
E
P
V
GV
V
A
G
I
V
PWNFP
LM
I
GM
WK
VM
PALAAG
C
S
I
V
I
KPSE
T
TPLT
M
L
RV
A
E
L
AS
EAG
I
P
D
GV
F
NVV
T
G
S
G
AVC
G
AA
LT
S
HP
H
V
AK
I
S
F
TGS
TA
TGK
G
I
ART
A
A
D
-
HL
T
RV
T
LELGGK
N
P
A
IV
LK
D
-
AD
-----
P
Q
W
V
IEGLMTGSFL
N
Q
GQVC
AASS
R
I
YIEAPLF
D
T
L
VSGFEQAVKSL
Q
V
G
PGMSPV
-
AQI
N
PL
V
S
R
AH
C
D
K
V
CSF
L
DD
A
QAQ
Q
-
AE
L
IR
G
S
--
NGPA
R
--
-
-
E
GY
YVA
PTL
VVNPDAKLR
L
TR
EE
V
FGPV
V
N
L
VRVADG
EEA
L
QL
AND
T
E
YGL
T
A
S
V
W
T
Q
N
L
SQ
A
L
E
Y
S
DR
L
Q
A
G
TV
WVN
SHTLIDANL
P
F
GG
M
K
Q
SG
T
G
RDF
G
PDW
L
DG
W
CET
K
S
V
C
V
fig|344610.3.peg.1116
Escherichia coli 53638 (5-497/499)
H
V
A
VLSQVQ
Q
F
LDR
Q
HG
L
Y
I
D
G
RPGPAQSE
---
KRLAIF
D
PAT
GQE
I
ASTAD
A
NEA
D
V
D
N
AV
M
S
A
WRA
F
VSRR
W
AGRL
P
AE
R
ERI
L
L
R
FA
D
L
V
E
QHSE
E
L
A
Q
LE
TL
E
Q
GK
SIAISRAF
E
V
GCTLNWMR
Y
T
AG
LTTKIA
G
KTLDLS
IPL
PQGARYQAWTR
K
E
P
V
GV
V
A
G
I
V
PWNFP
LM
I
GM
WK
VM
PALAAG
C
S
I
V
I
KPSE
T
TPLT
M
L
RV
A
E
L
AS
EAG
I
P
D
GV
F
NVV
T
G
S
G
AVC
G
AA
LT
S
HP
H
V
AK
I
S
F
TGS
TA
TGK
G
I
ART
A
A
D
-
HL
T
RV
T
LELGGK
N
P
A
IV
LK
D
-
AD
-----
P
Q
W
V
IEGLMTGSFL
N
Q
GQVC
AASS
R
I
YIEAPLF
D
T
L
VSGFEQAVKSL
Q
V
G
PGMSPV
-
AQI
N
PL
V
S
R
AH
C
D
K
V
CSF
L
DD
A
QAQ
Q
-
AE
L
IR
G
S
--
NGPA
G
--
-
-
E
GY
YVA
PTL
VVNPDAKLR
L
TR
EE
V
FGPV
V
N
L
VRVADG
EEA
L
QL
AND
T
E
YGL
T
A
S
V
W
T
Q
N
L
SQ
A
L
E
Y
S
DR
L
Q
A
G
TV
WVN
SHTLIDANL
P
F
GG
M
K
Q
SG
T
G
RDF
G
PDW
L
DG
W
CET
K
S
V
C
V
fig|344610.7.peg.5044
Escherichia coli 53638 (5-497/499)
H
V
A
VLSQVQ
Q
F
LDR
Q
HG
L
Y
I
D
G
RPGPAQSE
---
KRLAIF
D
PAT
GQE
I
ASTAD
A
NEA
D
V
D
N
AV
M
S
A
WRA
F
VSRR
W
AGRL
P
AE
R
ERI
L
L
R
FA
D
L
V
E
QHSE
E
L
A
Q
LE
TL
E
Q
GK
SIAISRAF
E
V
GCTLNWMR
Y
T
AG
LTTKIA
G
KTLDLS
IPL
PQGARYQAWTR
K
E
P
V
GV
V
A
G
I
V
PWNFP
LM
I
GM
WK
VM
PALAAG
C
S
I
V
I
KPSE
T
TPLT
M
L
RV
A
E
L
AS
EAG
I
P
D
GV
F
NVV
T
G
S
G
AVC
G
AA
LT
S
HP
H
V
AK
I
S
F
TGS
TA
TGK
G
I
ART
A
A
D
-
HL
T
RV
T
LELGGK
N
P
A
IV
LK
D
-
AD
-----
P
Q
W
V
IEGLMTGSFL
N
Q
GQVC
AASS
R
I
YIEAPLF
D
T
L
VSGFEQAVKSL
Q
V
G
PGMSPV
-
AQI
N
PL
V
S
R
AH
C
D
K
V
CSF
L
DD
A
QAQ
Q
-
AE
L
IR
G
S
--
NGPA
G
--
-
-
E
GY
YVA
PTL
VVNPDAKLR
L
TR
EE
V
FGPV
V
N
L
VRVADG
EEA
L
QL
AND
T
E
YGL
T
A
S
V
W
T
Q
N
L
SQ
A
L
E
Y
S
DR
L
Q
A
G
TV
WVN
SHTLIDANL
P
F
GG
M
K
Q
SG
T
G
RDF
G
PDW
L
DG
W
CET
K
S
V
C
V
fig|550672.3.peg.885
Escherichia coli B088 (5-497/499)
H
V
A
VLSQVQ
Q
F
LDR
Q
HG
L
Y
I
D
G
RPGPAQSE
---
KRLAIF
D
PAT
GQE
I
ASTAD
A
NEA
D
V
D
N
AV
M
S
A
WRA
F
VSRR
W
AGRL
P
AE
R
ERI
L
L
R
FA
D
L
V
E
QHSE
E
L
A
Q
LE
TL
E
Q
GK
SIAISRAF
E
V
GCTLNWMR
Y
T
AG
LTTKIA
G
KTLDLS
IPL
PQGARYQAWTR
K
E
P
V
GV
V
A
G
I
V
PWNFP
LM
I
GM
WK
VM
PALAAG
C
S
I
V
I
KPSE
T
TPLT
M
L
RV
A
E
L
AS
EAG
I
P
D
GV
F
NVV
T
G
S
G
AVC
G
AA
LT
S
HP
H
V
AK
I
S
F
TGS
TA
TGK
G
I
ART
A
A
D
-
HL
T
RV
T
LELGGK
N
P
A
IV
LK
D
-
AD
-----
P
Q
W
V
IEGLMTGSFL
N
Q
GQVC
AASS
R
I
YIEAPLF
D
T
L
VSGFEQAVKSL
Q
V
G
PGMSPV
-
AQI
N
PL
V
S
R
AH
C
D
K
V
CSF
L
DD
A
QAQ
Q
-
AE
L
IR
G
S
--
NGPA
G
--
-
-
E
GY
YVA
PTL
VVNPDAKLR
L
TR
EE
V
FGPV
V
N
L
VRVADG
EEA
L
QL
AND
T
E
YGL
T
A
S
V
W
T
Q
N
L
SQ
A
L
E
Y
S
DR
L
Q
A
G
TV
WVN
SHTLIDANL
P
F
GG
M
K
Q
SG
T
G
RDF
G
PDW
L
DG
W
CET
K
S
V
C
V
fig|344601.3.peg.192
Escherichia coli B171 (5-497/499)
H
V
A
VLSQVQ
Q
F
LDR
Q
HG
L
Y
I
D
G
RPGPAQSE
---
KRLAIF
D
PAT
GQE
I
ASTAD
A
NEA
D
V
D
N
AV
M
S
A
WRA
F
VSRR
W
AGRL
P
AE
R
ERI
L
L
R
FA
D
L
V
E
QHSE
E
L
A
Q
LE
TL
E
Q
GK
SIAISRAF
E
V
GCTLNWMR
Y
T
AG
LTTKIA
G
KTLDLS
IPL
PQGARYQAWTR
K
E
P
V
GV
V
A
G
I
V
PWNFP
LM
I
GM
WK
VM
PALAAG
C
S
I
V
I
KPSE
T
TPLT
M
L
RV
A
E
L
AS
EAG
I
P
D
GV
F
NVV
T
G
S
G
AVC
G
AA
LT
S
HP
H
V
AK
I
S
F
TGS
TA
TGK
G
I
ART
A
A
D
-
HL
T
RV
T
LELGGK
N
P
A
IV
LK
D
-
AD
-----
P
Q
W
V
IEGLMTGSFL
N
Q
GQVC
AASS
R
I
YIEAPLF
D
T
L
VSGFEQAVKSL
Q
V
G
PGMSPV
-
AQI
N
PL
V
S
R
AH
C
D
K
V
CSF
L
DD
A
QAQ
Q
-
AE
L
IR
G
S
--
NGPA
G
--
-
-
E
GY
YVA
PTL
VVNPDAKLR
L
TR
EE
V
FGPV
V
N
L
VRVADG
EEA
L
QL
AND
T
E
YGL
T
A
S
V
W
T
Q
N
L
SQ
A
L
E
Y
S
DR
L
Q
A
G
TV
WVN
SHTLIDANL
P
F
GG
M
K
Q
SG
T
G
RDF
G
PDW
L
DG
W
CET
K
S
V
C
V
fig|344601.5.peg.189
Escherichia coli B171 (5-497/499)
H
V
A
VLSQVQ
Q
F
LDR
Q
HG
L
Y
I
D
G
RPGPAQSE
---
KRLAIF
D
PAT
GQE
I
ASTAD
A
NEA
D
V
D
N
AV
M
S
A
WRA
F
VSRR
W
AGRL
P
AE
R
ERI
L
L
R
FA
D
L
V
E
QHSE
E
L
A
Q
LE
TL
E
Q
GK
SIAISRAF
E
V
GCTLNWMR
Y
T
AG
LTTKIA
G
KTLDLS
IPL
PQGARYQAWTR
K
E
P
V
GV
V
A
G
I
V
PWNFP
LM
I
GM
WK
VM
PALAAG
C
S
I
V
I
KPSE
T
TPLT
M
L
RV
A
E
L
AS
EAG
I
P
D
GV
F
NVV
T
G
S
G
AVC
G
AA
LT
S
HP
H
V
AK
I
S
F
TGS
TA
TGK
G
I
ART
A
A
D
-
HL
T
RV
T
LELGGK
N
P
A
IV
LK
D
-
AD
-----
P
Q
W
V
IEGLMTGSFL
N
Q
GQVC
AASS
R
I
YIEAPLF
D
T
L
VSGFEQAVKSL
Q
V
G
PGMSPV
-
AQI
N
PL
V
S
R
AH
C
D
K
V
CSF
L
DD
A
QAQ
Q
-
AE
L
IR
G
S
--
NGPA
G
--
-
-
E
GY
YVA
PTL
VVNPDAKLR
L
TR
EE
V
FGPV
V
N
L
VRVADG
EEA
L
QL
AND
T
E
YGL
T
A
S
V
W
T
Q
N
L
SQ
A
L
E
Y
S
DR
L
Q
A
G
TV
WVN
SHTLIDANL
P
F
GG
M
K
Q
SG
T
G
RDF
G
PDW
L
DG
W
CET
K
S
V
C
V
fig|340184.3.peg.175
Escherichia coli B7A (5-497/499)
H
V
A
VLSQVQ
Q
F
LDR
Q
HG
L
Y
I
D
G
RPGPAQSE
---
KRLAIF
D
PAT
GQE
I
ASTAD
A
NEA
D
V
D
N
AV
M
S
A
WRA
F
VSRR
W
AGRL
P
AE
R
ERI
L
L
R
FA
D
L
V
E
QHSE
E
L
A
Q
LE
TL
E
Q
GK
SIAISRAF
E
V
GCTLNWMR
Y
T
AG
LTTKIA
G
KTLDLS
IPL
PQGARYQAWTR
K
E
P
V
GV
V
A
G
I
V
PWNFP
LM
I
GM
WK
VM
PALAAG
C
S
I
V
I
KPSE
T
TPLT
M
L
RV
A
E
L
AS
EAG
I
P
D
GV
F
NVV
T
G
S
G
AVC
G
AA
LT
S
HP
H
V
AK
I
S
F
TGS
TA
TGK
G
I
ART
A
A
D
-
HL
T
RV
T
LELGGK
N
P
A
IV
LK
D
-
AD
-----
P
Q
W
V
IEGLMTGSFL
N
Q
GQVC
AASS
R
I
YIEAPLF
D
T
L
VSGFEQAVKSL
Q
V
G
PGMSPV
-
AQI
N
PL
V
S
R
AH
C
D
K
V
CSF
L
DD
A
QAQ
Q
-
AE
L
IR
G
S
--
NGPA
G
--
-
-
E
GY
YVA
PTL
VVNPDAKLR
L
TR
EE
V
FGPV
V
N
L
VRVADG
EEA
L
QL
AND
T
E
YGL
T
A
S
V
W
T
Q
N
L
SQ
A
L
E
Y
S
DR
L
Q
A
G
TV
WVN
SHTLIDANL
P
F
GG
M
K
Q
SG
T
G
RDF
G
PDW
L
DG
W
CET
K
S
V
C
V
fig|340184.6.peg.181
Escherichia coli B7A (5-497/499)
H
V
A
VLSQVQ
Q
F
LDR
Q
HG
L
Y
I
D
G
RPGPAQSE
---
KRLAIF
D
PAT
GQE
I
ASTAD
A
NEA
D
V
D
N
AV
M
S
A
WRA
F
VSRR
W
AGRL
P
AE
R
ERI
L
L
R
FA
D
L
V
E
QHSE
E
L
A
Q
LE
TL
E
Q
GK
SIAISRAF
E
V
GCTLNWMR
Y
T
AG
LTTKIA
G
KTLDLS
IPL
PQGARYQAWTR
K
E
P
V
GV
V
A
G
I
V
PWNFP
LM
I
GM
WK
VM
PALAAG
C
S
I
V
I
KPSE
T
TPLT
M
L
RV
A
E
L
AS
EAG
I
P
D
GV
F
NVV
T
G
S
G
AVC
G
AA
LT
S
HP
H
V
AK
I
S
F
TGS
TA
TGK
G
I
ART
A
A
D
-
HL
T
RV
T
LELGGK
N
P
A
IV
LK
D
-
AD
-----
P
Q
W
V
IEGLMTGSFL
N
Q
GQVC
AASS
R
I
YIEAPLF
D
T
L
VSGFEQAVKSL
Q
V
G
PGMSPV
-
AQI
N
PL
V
S
R
AH
C
D
K
V
CSF
L
DD
A
QAQ
Q
-
AE
L
IR
G
S
--
NGPA
G
--
-
-
E
GY
YVA
PTL
VVNPDAKLR
L
TR
EE
V
FGPV
V
N
L
VRVADG
EEA
L
QL
AND
T
E
YGL
T
A
S
V
W
T
Q
N
L
SQ
A
L
E
Y
S
DR
L
Q
A
G
TV
WVN
SHTLIDANL
P
F
GG
M
K
Q
SG
T
G
RDF
G
PDW
L
DG
W
CET
K
S
V
C
V
fig|595496.3.peg.1337
Escherichia coli BW2952 (5-497/499)
H
V
A
VLSQVQ
Q
F
LDR
Q
HG
L
Y
I
D
G
RPGPAQSE
---
KRLAIF
D
PAT
GQE
I
ASTAD
A
NEA
D
V
D
N
AV
M
S
A
WRA
F
VSRR
W
AGRL
P
AE
R
ERI
L
L
R
FA
D
L
V
E
QHSE
E
L
A
Q
LE
TL
E
Q
GK
SIAISRAF
E
V
GCTLNWMR
Y
T
AG
LTTKIA
G
KTLDLS
IPL
PQGARYQAWTR
K
E
P
V
GV
V
A
G
I
V
PWNFP
LM
I
GM
WK
VM
PALAAG
C
S
I
V
I
KPSE
T
TPLT
M
L
RV
A
E
L
AS
EAG
I
P
D
GV
F
NVV
T
G
S
G
AVC
G
AA
LT
S
HP
H
V
AK
I
S
F
TGS
TA
TGK
G
I
ART
A
A
D
-
HL
T
RV
T
LELGGK
N
P
A
IV
LK
D
-
AD
-----
P
Q
W
V
IEGLMTGSFL
N
Q
GQVC
AASS
R
I
YIEAPLF
D
T
L
VSGFEQAVKSL
Q
V
G
PGMSPV
-
AQI
N
PL
V
S
R
AH
C
D
K
V
CSF
L
DD
A
QAQ
Q
-
AE
L
IR
G
S
--
NGPA
G
--
-
-
E
GY
YVA
PTL
VVNPDAKLR
L
TR
EE
V
FGPV
V
N
L
VRVADG
EEA
L
QL
AND
T
E
YGL
T
A
S
V
W
T
Q
N
L
SQ
A
L
E
Y
S
DR
L
Q
A
G
TV
WVN
SHTLIDANL
P
F
GG
M
K
Q
SG
T
G
RDF
G
PDW
L
DG
W
CET
K
S
V
C
V
fig|536056.3.peg.2373
Escherichia coli DH1 (5-497/499)
H
V
A
VLSQVQ
Q
F
LDR
Q
HG
L
Y
I
D
G
RPGPAQSE
---
KRLAIF
D
PAT
GQE
I
ASTAD
A
NEA
D
V
D
N
AV
M
S
A
WRA
F
VSRR
W
AGRL
P
AE
R
ERI
L
L
R
FA
D
L
V
E
QHSE
E
L
A
Q
LE
TL
E
Q
GK
SIAISRAF
E
V
GCTLNWMR
Y
T
AG
LTTKIA
G
KTLDLS
IPL
PQGARYQAWTR
K
E
P
V
GV
V
A
G
I
V
PWNFP
LM
I
GM
WK
VM
PALAAG
C
S
I
V
I
KPSE
T
TPLT
M
L
RV
A
E
L
AS
EAG
I
P
D
GV
F
NVV
T
G
S
G
AVC
G
AA
LT
S
HP
H
V
AK
I
S
F
TGS
TA
TGK
G
I
ART
A
A
D
-
HL
T
RV
T
LELGGK
N
P
A
IV
LK
D
-
AD
-----
P
Q
W
V
IEGLMTGSFL
N
Q
GQVC
AASS
R
I
YIEAPLF
D
T
L
VSGFEQAVKSL
Q
V
G
PGMSPV
-
AQI
N
PL
V
S
R
AH
C
D
K
V
CSF
L
DD
A
QAQ
Q
-
AE
L
IR
G
S
--
NGPA
G
--
-
-
E
GY
YVA
PTL
VVNPDAKLR
L
TR
EE
V
FGPV
V
N
L
VRVADG
EEA
L
QL
AND
T
E
YGL
T
A
S
V
W
T
Q
N
L
SQ
A
L
E
Y
S
DR
L
Q
A
G
TV
WVN
SHTLIDANL
P
F
GG
M
K
Q
SG
T
G
RDF
G
PDW
L
DG
W
CET
K
S
V
C
V
fig|340186.3.peg.255
Escherichia coli E110019 (5-497/499)
H
V
A
VLSQVQ
Q
F
LDR
Q
HG
L
Y
I
D
G
RPGPAQSE
---
KRLAIF
D
PAT
GQE
I
ASTAD
A
NEA
D
V
D
N
AV
M
S
A
WRA
F
VSRR
W
AGRL
P
AE
R
ERI
L
L
R
FA
D
L
V
E
QHSE
E
L
A
Q
LE
TL
E
Q
GK
SIAISRAF
E
V
GCTLNWMR
Y
T
AG
LTTKIA
G
KTLDLS
IPL
PQGARYQAWTR
K
E
P
V
GV
V
A
G
I
V
PWNFP
LM
I
GM
WK
VM
PALAAG
C
S
I
V
I
KPSE
T
TPLT
M
L
RV
A
E
L
AS
EAG
I
P
D
GV
F
NVV
T
G
S
G
AVC
G
AA
LT
S
HP
H
V
AK
I
S
F
TGS
TA
TGK
G
I
ART
A
A
D
-
HL
T
RV
T
LELGGK
N
P
A
IV
LK
D
-
AD
-----
P
Q
W
V
IEGLMTGSFL
N
Q
GQVC
AASS
R
I
YIEAPLF
D
T
L
VSGFEQAVKSL
Q
V
G
PGMSPV
-
AQI
N
PL
V
S
R
AH
C
D
K
V
CSF
L
DD
A
QAQ
Q
-
AE
L
IR
G
S
--
NGPA
G
--
-
-
E
GY
YVA
PTL
VVNPDAKLR
L
TR
EE
V
FGPV
V
N
L
VRVADG
EEA
L
QL
AND
T
E
YGL
T
A
S
V
W
T
Q
N
L
SQ
A
L
E
Y
S
DR
L
Q
A
G
TV
WVN
SHTLIDANL
P
F
GG
M
K
Q
SG
T
G
RDF
G
PDW
L
DG
W
CET
K
S
V
C
V
fig|340186.5.peg.271
Escherichia coli E110019 (5-497/499)
H
V
A
VLSQVQ
Q
F
LDR
Q
HG
L
Y
I
D
G
RPGPAQSE
---
KRLAIF
D
PAT
GQE
I
ASTAD
A
NEA
D
V
D
N
AV
M
S
A
WRA
F
VSRR
W
AGRL
P
AE
R
ERI
L
L
R
FA
D
L
V
E
QHSE
E
L
A
Q
LE
TL
E
Q
GK
SIAISRAF
E
V
GCTLNWMR
Y
T
AG
LTTKIA
G
KTLDLS
IPL
PQGARYQAWTR
K
E
P
V
GV
V
A
G
I
V
PWNFP
LM
I
GM
WK
VM
PALAAG
C
S
I
V
I
KPSE
T
TPLT
M
L
RV
A
E
L
AS
EAG
I
P
D
GV
F
NVV
T
G
S
G
AVC
G
AA
LT
S
HP
H
V
AK
I
S
F
TGS
TA
TGK
G
I
ART
A
A
D
-
HL
T
RV
T
LELGGK
N
P
A
IV
LK
D
-
AD
-----
P
Q
W
V
IEGLMTGSFL
N
Q
GQVC
AASS
R
I
YIEAPLF
D
T
L
VSGFEQAVKSL
Q
V
G
PGMSPV
-
AQI
N
PL
V
S
R
AH
C
D
K
V
CSF
L
DD
A
QAQ
Q
-
AE
L
IR
G
S
--
NGPA
G
--
-
-
E
GY
YVA
PTL
VVNPDAKLR
L
TR
EE
V
FGPV
V
N
L
VRVADG
EEA
L
QL
AND
T
E
YGL
T
A
S
V
W
T
Q
N
L
SQ
A
L
E
Y
S
DR
L
Q
A
G
TV
WVN
SHTLIDANL
P
F
GG
M
K
Q
SG
T
G
RDF
G
PDW
L
DG
W
CET
K
S
V
C
V
fig|340185.3.peg.1021
Escherichia coli E22 (5-497/499)
H
V
A
VLSQVQ
Q
F
LDR
Q
HG
L
Y
I
D
G
RPGPAQSE
---
KRLAIF
D
PAT
GQE
I
ASTAD
A
NEA
D
V
D
N
AV
M
S
A
WRA
F
VSRR
W
AGRL
P
AE
R
ERI
L
L
R
FA
D
L
V
E
QHSE
E
L
A
Q
LE
TL
E
Q
GK
SIAISRAF
E
V
GCTLNWMR
Y
T
AG
LTTKIA
G
KTLDLS
IPL
PQGARYQAWTR
K
E
P
V
GV
V
A
G
I
V
PWNFP
LM
I
GM
WK
VM
PALAAG
C
S
I
V
I
KPSE
T
TPLT
M
L
RV
A
E
L
AS
EAG
I
P
D
GV
F
NVV
T
G
S
G
AVC
G
AA
LT
S
HP
H
V
AK
I
S
F
TGS
TA
TGK
G
I
ART
A
A
D
-
HL
T
RV
T
LELGGK
N
P
A
IV
LK
D
-
AD
-----
P
Q
W
V
IEGLMTGSFL
N
Q
GQVC
AASS
R
I
YIEAPLF
D
T
L
VSGFEQAVKSL
Q
V
G
PGMSPV
-
AQI
N
PL
V
S
R
AH
C
D
K
V
CSF
L
DD
A
QAQ
Q
-
AE
L
IR
G
S
--
NGPA
G
--
-
-
E
GY
YVA
PTL
VVNPDAKLR
L
TR
EE
V
FGPV
V
N
L
VRVADG
EEA
L
QL
AND
T
E
YGL
T
A
S
V
W
T
Q
N
L
SQ
A
L
E
Y
S
DR
L
Q
A
G
TV
WVN
SHTLIDANL
P
F
GG
M
K
Q
SG
T
G
RDF
G
PDW
L
DG
W
CET
K
S
V
C
V
fig|340185.4.peg.1072
Escherichia coli E22 (5-497/499)
H
V
A
VLSQVQ
Q
F
LDR
Q
HG
L
Y
I
D
G
RPGPAQSE
---
KRLAIF
D
PAT
GQE
I
ASTAD
A
NEA
D
V
D
N
AV
M
S
A
WRA
F
VSRR
W
AGRL
P
AE
R
ERI
L
L
R
FA
D
L
V
E
QHSE
E
L
A
Q
LE
TL
E
Q
GK
SIAISRAF
E
V
GCTLNWMR
Y
T
AG
LTTKIA
G
KTLDLS
IPL
PQGARYQAWTR
K
E
P
V
GV
V
A
G
I
V
PWNFP
LM
I
GM
WK
VM
PALAAG
C
S
I
V
I
KPSE
T
TPLT
M
L
RV
A
E
L
AS
EAG
I
P
D
GV
F
NVV
T
G
S
G
AVC
G
AA
LT
S
HP
H
V
AK
I
S
F
TGS
TA
TGK
G
I
ART
A
A
D
-
HL
T
RV
T
LELGGK
N
P
A
IV
LK
D
-
AD
-----
P
Q
W
V
IEGLMTGSFL
N
Q
GQVC
AASS
R
I
YIEAPLF
D
T
L
VSGFEQAVKSL
Q
V
G
PGMSPV
-
AQI
N
PL
V
S
R
AH
C
D
K
V
CSF
L
DD
A
QAQ
Q
-
AE
L
IR
G
S
--
NGPA
G
--
-
-
E
GY
YVA
PTL
VVNPDAKLR
L
TR
EE
V
FGPV
V
N
L
VRVADG
EEA
L
QL
AND
T
E
YGL
T
A
S
V
W
T
Q
N
L
SQ
A
L
E
Y
S
DR
L
Q
A
G
TV
WVN
SHTLIDANL
P
F
GG
M
K
Q
SG
T
G
RDF
G
PDW
L
DG
W
CET
K
S
V
C
V
fig|331111.12.peg.1854
Escherichia coli E24377A (5-497/499)
H
V
A
VLSQVQ
Q
F
LDR
Q
HG
L
Y
I
D
G
RPGPAQSE
---
KRLAIF
D
PAT
GQE
I
ASTAD
A
NEA
D
V
D
N
AV
M
S
A
WRA
F
VSRR
W
AGRL
P
AE
R
ERI
L
L
R
FA
D
L
V
E
QHSE
E
L
A
Q
LE
TL
E
Q
GK
SIAISRAF
E
V
GCTLNWMR
Y
T
AG
LTTKIA
G
KTLDLS
IPL
PQGARYQAWTR
K
E
P
V
GV
V
A
G
I
V
PWNFP
LM
I
GM
WK
VM
PALAAG
C
S
I
V
I
KPSE
T
TPLT
M
L
RV
A
E
L
AS
EAG
I
P
D
GV
F
NVV
T
G
S
G
AVC
G
AA
LT
S
HP
H
V
AK
I
S
F
TGS
TA
TGK
G
I
ART
A
A
D
-
HL
T
RV
T
LELGGK
N
P
A
IV
LK
D
-
AD
-----
P
Q
W
V
IEGLMTGSFL
N
Q
GQVC
AASS
R
I
YIEAPLF
D
T
L
VSGFEQAVKSL
Q
V
G
PGMSPV
-
AQI
N
PL
V
S
R
AH
C
D
K
V
CSF
L
DD
A
QAQ
Q
-
AE
L
IR
G
S
--
NGPA
G
--
-
-
E
GY
YVA
PTL
VVNPDAKLR
L
TR
EE
V
FGPV
V
N
L
VRVADG
EEA
L
QL
AND
T
E
YGL
T
A
S
V
W
T
Q
N
L
SQ
A
L
E
Y
S
DR
L
Q
A
G
TV
WVN
SHTLIDANL
P
F
GG
M
K
Q
SG
T
G
RDF
G
PDW
L
DG
W
CET
K
S
V
C
V
fig|331111.3.peg.4015
Escherichia coli E24377A (5-497/499)
H
V
A
VLSQVQ
Q
F
LDR
Q
HG
L
Y
I
D
G
RPGPAQSE
---
KRLAIF
D
PAT
GQE
I
ASTAD
A
NEA
D
V
D
N
AV
M
S
A
WRA
F
VSRR
W
AGRL
P
AE
R
ERI
L
L
R
FA
D
L
V
E
QHSE
E
L
A
Q
LE
TL
E
Q
GK
SIAISRAF
E
V
GCTLNWMR
Y
T
AG
LTTKIA
G
KTLDLS
IPL
PQGARYQAWTR
K
E
P
V
GV
V
A
G
I
V
PWNFP
LM
I
GM
WK
VM
PALAAG
C
S
I
V
I
KPSE
T
TPLT
M
L
RV
A
E
L
AS
EAG
I
P
D
GV
F
NVV
T
G
S
G
AVC
G
AA
LT
S
HP
H
V
AK
I
S
F
TGS
TA
TGK
G
I
ART
A
A
D
-
HL
T
RV
T
LELGGK
N
P
A
IV
LK
D
-
AD
-----
P
Q
W
V
IEGLMTGSFL
N
Q
GQVC
AASS
R
I
YIEAPLF
D
T
L
VSGFEQAVKSL
Q
V
G
PGMSPV
-
AQI
N
PL
V
S
R
AH
C
D
K
V
CSF
L
DD
A
QAQ
Q
-
AE
L
IR
G
S
--
NGPA
G
--
-
-
E
GY
YVA
PTL
VVNPDAKLR
L
TR
EE
V
FGPV
V
N
L
VRVADG
EEA
L
QL
AND
T
E
YGL
T
A
S
V
W
T
Q
N
L
SQ
A
L
E
Y
S
DR
L
Q
A
G
TV
WVN
SHTLIDANL
P
F
GG
M
K
Q
SG
T
G
RDF
G
PDW
L
DG
W
CET
K
S
V
C
V
fig|656408.3.peg.1517
Escherichia coli H591 (5-497/499)
H
V
A
VLSQVQ
Q
F
LDR
Q
HG
L
Y
I
D
G
RPGPAQSE
---
KRLAIF
D
PAT
GQE
I
ASTAD
A
NEA
D
V
D
N
AV
M
S
A
WRA
F
VSRR
W
AGRL
P
AE
R
ERI
L
L
R
FA
D
L
V
E
QHSE
E
L
A
Q
LE
TL
E
Q
GK
SIAISRAF
E
V
GCTLNWMR
Y
T
AG
LTTKIA
G
KTLDLS
IP
F
PQGARYQAWTR
K
E
P
V
GV
V
A
G
I
V
PWNFP
LM
I
GM
WK
VM
PALAAG
C
S
I
V
I
KPSE
T
TPLT
M
L
RV
A
E
L
AS
EAG
I
P
D
GV
F
NVV
T
G
S
G
AVC
G
AA
LT
S
HP
H
V
AK
I
S
F
TGS
TA
TGK
G
I
ART
A
A
D
-
HL
T
RV
T
LELGGK
N
P
A
IV
LK
D
-
AD
-----
P
Q
W
V
IEGLMTGSFL
N
Q
GQVC
AASS
R
I
YIEAPLF
D
T
L
VSGFEQAVKSL
Q
V
G
PGMSPV
-
AQI
N
PL
V
S
R
AH
C
D
K
V
CSF
L
DD
A
QAQ
Q
-
AE
L
IR
G
S
--
NGPA
G
--
-
-
E
GY
YVA
PTL
VVNPDAKLR
L
TR
EE
V
FGPV
V
N
L
VRVADG
EEA
L
QL
AND
T
E
YGL
T
A
S
V
W
T
Q
N
L
SQ
A
L
E
Y
S
DR
L
Q
A
G
TV
WVN
SHTLIDANL
P
F
GG
M
K
Q
SG
T
G
RDF
G
PDW
L
DG
W
CET
K
S
V
C
V
fig|656414.3.peg.1667
Escherichia coli H736 (5-497/499)
H
V
A
VLSQVQ
Q
F
LDR
Q
HG
L
Y
I
D
G
RPGPAQSE
---
KRLAIF
D
PAT
GQE
I
ASTAD
A
NEA
D
V
D
N
AV
M
S
A
WRA
F
VSRR
W
AGRL
P
AE
R
ERI
L
L
R
FA
D
L
V
E
QHSE
E
L
A
Q
LE
TL
E
Q
GK
SIAISRAF
E
V
GCTLNWMR
Y
T
AG
LTTKIA
G
KTLDLS
IPL
PQGARYQAWTR
K
E
P
V
GV
V
A
G
I
V
PWNFP
LM
I
GM
WK
VM
PALAAG
C
S
I
V
I
KPSE
T
TPLT
M
L
RV
A
E
L
AS
EAG
I
P
D
GV
F
NVV
T
G
S
G
AVC
G
AA
LT
S
HP
H
V
AK
I
S
F
TGS
TA
TGK
G
I
ART
A
A
D
-
HL
T
RV
T
LELGGK
N
P
A
IV
LK
D
-
AD
-----
P
Q
W
V
IEGLMTGSFL
N
Q
GQVC
AASS
R
I
YIEAPLF
D
T
L
VSGFEQAVKSL
Q
V
G
PGMSPV
-
AQI
N
PL
V
S
R
AH
C
D
K
V
CSF
L
DD
A
QAQ
Q
-
AE
L
IR
G
S
--
NGPA
G
--
-
-
E
GY
YVA
PTL
VVNPDAKLR
L
TR
EE
V
FGPV
V
N
L
VRVADG
EEA
L
QL
AND
T
E
YGL
T
A
S
V
W
T
Q
N
L
SQ
A
L
E
Y
S
DR
L
Q
A
G
TV
WVN
SHTLIDANL
P
F
GG
M
K
Q
SG
T
G
RDF
G
PDW
L
DG
W
CET
K
S
V
C
V
fig|83333.1.peg.1375
Escherichia coli K12 (5-497/499)
H
V
A
VLSQVQ
Q
F
LDR
Q
HG
L
Y
I
D
G
RPGPAQSE
---
KRLAIF
D
PAT
GQE
I
ASTAD
A
NEA
D
V
D
N
AV
M
S
A
WRA
F
VSRR
W
AGRL
P
AE
R
ERI
L
L
R
FA
D
L
V
E
QHSE
E
L
A
Q
LE
TL
E
Q
GK
SIAISRAF
E
V
GCTLNWMR
Y
T
AG
LTTKIA
G
KTLDLS
IPL
PQGARYQAWTR
K
E
P
V
GV
V
A
G
I
V
PWNFP
LM
I
GM
WK
VM
PALAAG
C
S
I
V
I
KPSE
T
TPLT
M
L
RV
A
E
L
AS
EAG
I
P
D
GV
F
NVV
T
G
S
G
AVC
G
AA
LT
S
HP
H
V
AK
I
S
F
TGS
TA
TGK
G
I
ART
A
A
D
-
HL
T
RV
T
LELGGK
N
P
A
IV
LK
D
-
AD
-----
P
Q
W
V
IEGLMTGSFL
N
Q
GQVC
AASS
R
I
YIEAPLF
D
T
L
VSGFEQAVKSL
Q
V
G
PGMSPV
-
AQI
N
PL
V
S
R
AH
C
D
K
V
CSF
L
DD
A
QAQ
Q
-
AE
L
IR
G
S
--
NGPA
G
--
-
-
E
GY
YVA
PTL
VVNPDAKLR
L
TR
EE
V
FGPV
V
N
L
VRVADG
EEA
L
QL
AND
T
E
YGL
T
A
S
V
W
T
Q
N
L
SQ
A
L
E
Y
S
DR
L
Q
A
G
TV
WVN
SHTLIDANL
P
F
GG
M
K
Q
SG
T
G
RDF
G
PDW
L
DG
W
CET
K
S
V
C
V
fig|749537.3.peg.473
Escherichia coli MS 115-1 (5-497/499)
H
V
A
VLSQVQ
Q
F
LDR
Q
HG
L
Y
I
D
G
RPGPAQSE
---
KRLAIF
D
PAT
GQE
I
ASTAD
A
NEA
D
V
D
N
AV
M
S
A
WRA
F
VSRR
W
AGRL
P
AE
R
ERI
L
L
R
FA
D
L
V
E
QHSE
E
L
A
Q
LE
TL
E
Q
GK
SIAISRAF
E
V
GCTLNWMR
Y
T
AG
LTTKIA
G
KTLDLS
IPL
PQGARYQAWTR
K
E
P
V
GV
V
A
G
I
V
PWNFP
LM
I
GM
WK
VM
PALAAG
C
S
I
V
I
KPSE
T
TPLT
M
L
RV
A
E
L
AS
EAG
I
P
D
GV
F
NVV
T
G
S
G
AVC
G
AA
LT
S
HP
H
V
AK
I
S
F
TGS
TA
TGK
G
I
ART
A
A
D
-
HL
T
RV
T
LELGGK
N
P
A
IV
LK
D
-
AD
-----
P
Q
W
V
IEGLMTGSFL
N
Q
GQVC
AASS
R
I
YIEAPLF
D
T
L
VSGFEQAVKSL
Q
V
G
PGMSPV
-
AQI
N
PL
V
S
R
AH
C
D
K
V
CSF
L
DD
A
QAQ
Q
-
AE
L
IR
G
S
--
NGPA
G
--
-
-
E
GY
YVA
PTL
VVNPDAKLR
L
TR
EE
V
FGPV
V
N
L
VRVADG
EEA
L
QL
AND
T
E
YGL
T
A
S
V
W
T
Q
N
L
SQ
A
L
E
Y
S
DR
L
Q
A
G
TV
WVN
SHTLIDANL
P
F
GG
M
K
Q
SG
T
G
RDF
G
PDW
L
DG
W
CET
K
S
V
C
V
fig|679206.4.peg.3069
Escherichia coli MS 119-7 (5-497/499)
H
V
A
VLSQVQ
Q
F
LDR
Q
HG
L
Y
I
D
G
RPGPAQSE
---
KRLAIF
D
PAT
GQE
I
ASTAD
A
NEA
D
V
D
N
AV
M
S
A
WRA
F
VSRR
W
AGRL
P
AE
R
ERI
L
L
R
FA
D
L
V
E
QHSE
E
L
A
Q
LE
TL
E
Q
GK
SIAISRAF
E
V
GCTLNWMR
Y
T
AG
LTTKIA
G
KTLDLS
IP
F
PQGARYQAWTR
K
E
P
V
GV
V
A
G
I
V
PWNFP
LM
I
GM
WK
VM
PALAAG
C
S
I
V
I
KPSE
T
TPLT
M
L
RV
A
E
L
AS
EAG
I
P
D
GV
F
NVV
T
G
S
G
AVC
G
AA
LT
S
HP
H
V
AK
I
S
F
TGS
TA
TGK
G
I
ART
A
A
D
-
HL
T
RV
T
LELGGK
N
P
A
IV
LK
D
-
AD
-----
P
Q
W
V
IEGLMTGSFL
N
Q
GQVC
AASS
R
I
YIEAPLF
D
T
L
VSGFEQAVKSL
Q
V
G
PGMSPV
-
AQI
N
PL
V
S
R
AH
C
D
K
V
CSF
L
DD
A
QAQ
Q
-
AE
L
IR
G
S
--
NGPA
G
--
-
-
E
GY
YVA
PTL
VVNPDAKLR
L
TR
EE
V
FGPV
V
N
L
VRVADG
EEA
L
QL
AND
T
E
YGL
T
A
S
V
W
T
Q
N
L
SQ
A
L
E
Y
S
DR
L
Q
A
G
TV
WVN
SHTLIDANL
P
F
GG
M
K
Q
SG
T
G
RDF
G
PDW
L
DG
W
CET
K
S
V
C
V
fig|679205.4.peg.3431
Escherichia coli MS 124-1 (5-497/499)
H
V
A
VLSQVQ
Q
F
LDR
Q
HG
L
Y
I
D
G
RPGPAQSE
---
KRLAIF
D
PAT
GQE
I
ASTAD
A
NEA
D
V
D
N
AV
M
S
A
WRA
F
VSRR
W
AGRL
P
AE
R
ERI
L
L
R
FA
D
L
V
E
QHSE
E
L
A
Q
LE
TL
E
Q
GK
SIAISRAF
E
V
GCTLNWMR
Y
T
AG
LTTKIA
G
KTLDLS
IPL
PQGARYQAWTR
K
E
P
V
GV
V
A
G
I
V
PWNFP
LM
I
GM
WK
VM
PALAAG
C
S
I
V
I
KPSE
T
TPLT
M
L
RV
A
E
L
AS
EAG
I
P
D
GV
F
NVV
T
G
S
G
AVC
G
AA
LT
S
HP
H
V
AK
I
S
F
TGS
TA
TGK
G
I
ART
A
A
D
-
HL
T
RV
T
LELGGK
N
P
A
IV
LK
D
-
AD
-----
P
Q
W
V
IEGLMTGSFL
N
Q
GQVC
AASS
R
I
YIEAPLF
D
T
L
VSGFEQAVKSL
Q
V
G
PGMSPV
-
AQI
N
PL
V
S
R
AH
C
D
K
V
CSF
L
DD
A
QAQ
Q
-
AE
L
IR
G
S
--
NGPA
G
--
-
-
E
GY
YVA
PTL
VVNPDAKLR
L
TR
EE
V
FGPV
V
N
L
VRVADG
EEA
L
QL
AND
T
E
YGL
T
A
S
V
W
T
Q
N
L
SQ
A
L
E
Y
S
DR
L
Q
A
G
TV
WVN
SHTLIDANL
P
F
GG
M
K
Q
SG
T
G
RDF
G
PDW
L
DG
W
CET
K
S
V
C
V
fig|679204.3.peg.4191
Escherichia coli MS 145-7 (5-497/499)
H
V
A
VLSQVQ
Q
F
LDR
Q
HG
L
Y
I
D
G
RPGPAQSE
---
KRLAIF
D
PAT
GQE
I
ASTAD
A
NEA
D
V
D
N
AV
M
S
A
WRA
F
VSRR
W
AGRL
P
AE
R
ERI
L
L
R
FA
D
L
V
E
QHSE
E
L
A
Q
LE
TL
E
Q
GK
SIAISRAF
E
V
GCTLNWMR
Y
T
AG
LTTKIA
G
KTLDLS
IPL
PQGARYQAWTR
K
E
P
V
GV
V
A
G
I
V
PWNFP
LM
I
GM
WK
VM
PALAAG
C
S
I
V
I
KPSE
T
TPLT
M
L
RV
A
E
L
AS
EAG
I
P
D
GV
F
NVV
T
G
S
G
AVC
G
AA
LT
S
HP
H
V
AK
I
S
F
TGS
TA
TGK
G
I
ART
A
A
D
-
HL
T
RV
T
LELGGK
N
P
A
IV
LK
D
-
AD
-----
P
Q
W
V
IEGLMTGSFL
N
Q
GQVC
AASS
R
I
YIEAPLF
D
T
L
VSGFEQAVKSL
Q
V
G
PGMSPV
-
AQI
N
PL
V
S
R
AH
C
D
K
V
CSF
L
DD
A
QAQ
Q
-
AE
L
IR
G
S
--
NGPA
G
--
-
-
E
GY
YVA
PTL
VVNPDAKLR
L
TR
EE
V
FGPV
V
N
L
VRVADG
EEA
L
QL
AND
T
E
YGL
T
A
S
V
W
T
Q
N
L
SQ
A
L
E
Y
S
DR
L
Q
A
G
TV
WVN
SHTLIDANL
P
F
GG
M
K
Q
SG
T
G
RDF
G
PDW
L
DG
W
CET
K
S
V
C
V
fig|749540.3.peg.3517
Escherichia coli MS 146-1 (5-497/499)
H
V
A
VLSQVQ
Q
F
LDR
Q
HG
L
Y
I
D
G
RPGPAQSE
---
KRLAIF
D
PAT
GQE
I
ASTAD
A
NEA
D
V
D
N
AV
M
S
A
WRA
F
VSRR
W
AGRL
P
AE
R
ERI
L
L
R
FA
D
L
V
E
QHSE
E
L
A
Q
LE
TL
E
Q
GK
SIAISRAF
E
V
GCTLNWMR
Y
T
AG
LTTKIA
G
KTLDLS
IPL
PQGARYQAWTR
K
E
P
V
GV
V
A
G
I
V
PWNFP
LM
I
GM
WK
VM
PALAAG
C
S
I
V
I
KPSE
T
TPLT
M
L
RV
A
E
L
AS
EAG
I
P
D
GV
F
NVV
T
G
S
G
AVC
G
AA
LT
S
HP
H
V
AK
I
S
F
TGS
TA
TGK
G
I
ART
A
A
D
-
HL
T
RV
T
LELGGK
N
P
A
IV
LK
D
-
AD
-----
P
Q
W
V
IEGLMTGSFL
N
Q
GQVC
AASS
R
I
YIEAPLF
D
T
L
VSGFEQAVKSL
Q
V
G
PGMSPV
-
AQI
N
PL
V
S
R
AH
C
D
K
V
CSF
L
DD
A
QAQ
Q
-
AE
L
IR
G
S
--
NGPA
G
--
-
-
E
GY
YVA
PTL
VVNPDAKLR
L
TR
EE
V
FGPV
V
N
L
VRVADG
EEA
L
QL
AND
T
E
YGL
T
A
S
V
W
T
Q
N
L
SQ
A
L
E
Y
S
DR
L
Q
A
G
TV
WVN
SHTLIDANL
P
F
GG
M
K
Q
SG
T
G
RDF
G
PDW
L
DG
W
CET
K
S
V
C
V
fig|749545.3.peg.1135
Escherichia coli MS 182-1 (5-497/499)
H
V
A
VLSQVQ
Q
F
LDR
Q
HG
L
Y
I
D
G
RPGPAQSE
---
KRLAIF
D
PAT
GQE
I
ASTAD
A
NEA
D
V
D
N
AV
M
S
A
WRA
F
VSRR
W
AGRL
P
AE
R
ERI
L
L
R
FA
D
L
V
E
QHSE
E
L
A
Q
LE
TL
E
Q
GK
SIAISRAF
E
V
GCTLNWMR
Y
T
AG
LTTKIA
G
KTLDLS
IPL
PQGARYQAWTR
K
E
P
V
GV
V
A
G
I
V
PWNFP
LM
I
GM
WK
VM
PALAAG
C
S
I
V
I
KPSE
T
TPLT
M
L
RV
A
E
L
AS
EAG
I
P
D
GV
F
NVV
T
G
S
G
AVC
G
AA
LT
S
HP
H
V
AK
I
S
F
TGS
TA
TGK
G
I
ART
A
A
D
-
HL
T
RV
T
LELGGK
N
P
A
IV
LK
D
-
AD
-----
P
Q
W
V
IEGLMTGSFL
N
Q
GQVC
AASS
R
I
YIEAPLF
D
T
L
VSGFEQAVKSL
Q
V
G
PGMSPV
-
AQI
N
PL
V
S
R
AH
C
D
K
V
CSF
L
DD
A
QAQ
Q
-
AE
L
IR
G
S
--
NGPA
G
--
-
-
E
GY
YVA
PTL
VVNPDAKLR
L
TR
EE
V
FGPV
V
N
L
VRVADG
EEA
L
QL
AND
T
E
YGL
T
A
S
V
W
T
Q
N
L
SQ
A
L
E
Y
S
DR
L
Q
A
G
TV
WVN
SHTLIDANL
P
F
GG
M
K
Q
SG
T
G
RDF
G
PDW
L
DG
W
CET
K
S
V
C
V
fig|749548.3.peg.486
Escherichia coli MS 196-1 (5-497/499)
H
V
A
VLSQVQ
Q
F
LDR
Q
HG
L
Y
I
D
G
RPGPAQSE
---
KRLAIF
D
PAT
GQE
I
ASTAD
A
NEA
D
V
D
N
AV
M
S
A
WRA
F
VSRR
W
AGRL
P
AE
R
ERI
L
L
R
FA
D
L
V
E
QHSE
E
L
A
Q
LE
TL
E
Q
GK
SIAISRAF
E
V
GCTLNWMR
Y
T
AG
LTTKIA
G
KTLDLS
IPL
PQGARYQAWTR
K
E
P
V
GV
V
A
G
I
V
PWNFP
LM
I
GM
WK
VM
PALAAG
C
S
I
V
I
KPSE
T
TPLT
M
L
RV
A
E
L
AS
EAG
I
P
D
GV
F
NVV
T
G
S
G
AVC
G
AA
LT
S
HP
H
V
AK
I
S
F
TGS
TA
TGK
G
I
ART
A
A
D
-
HL
T
RV
T
LELGGK
N
P
A
IV
LK
D
-
AD
-----
P
Q
W
V
IEGLMTGSFL
N
Q
GQVC
AASS
R
I
YIEAPLF
D
T
L
VSGFEQAVKSL
Q
V
G
PGMSPV
-
AQI
N
PL
V
S
R
AH
C
D
K
V
CSF
L
DD
A
QAQ
Q
-
AE
L
IR
G
S
--
NGPA
G
--
-
-
E
GY
YVA
PTL
VVNPDAKLR
L
TR
EE
V
FGPV
V
N
L
VRVADG
EEA
L
QL
AND
T
E
YGL
T
A
S
V
W
T
Q
N
L
SQ
A
L
E
Y
S
DR
L
Q
A
G
TV
WVN
SHTLIDANL
P
F
GG
M
K
Q
SG
T
G
RDF
G
PDW
L
DG
W
CET
K
S
V
C
V
fig|749532.3.peg.1733
Escherichia coli MS 78-1 (5-497/499)
H
V
A
VLSQVQ
Q
F
LDR
Q
HG
L
Y
I
D
G
RPGPAQSE
---
KRLAIF
D
PAT
GQE
I
ASTAD
A
NEA
D
V
D
N
AV
M
S
A
WRA
F
VSRR
W
AGRL
P
AE
R
ERI
L
L
R
FA
D
L
V
E
QHSE
E
L
A
Q
LE
TL
E
Q
GK
SIAISRAF
E
V
GCTLNWMR
Y
T
AG
LTTKIA
G
KTLDLS
IPL
PQGARYQAWTR
K
E
P
V
GV
V
A
G
I
V
PWNFP
LM
I
GM
WK
VM
PALAAG
C
S
I
V
I
KPSE
T
TPLT
M
L
RV
A
E
L
AS
EAG
I
P
D
GV
F
NVV
T
G
S
G
AVC
G
AA
LT
S
HP
H
V
AK
I
S
F
TGS
TA
TGK
G
I
ART
A
A
D
-
HL
T
RV
T
LELGGK
N
P
A
IV
LK
D
-
AD
-----
P
Q
W
V
IEGLMTGSFL
N
Q
GQVC
AASS
R
I
YIEAPLF
D
T
L
VSGFEQAVKSL
Q
V
G
PGMSPV
-
AQI
N
PL
V
S
R
AH
C
D
K
V
CSF
L
DD
A
QAQ
Q
-
AE
L
IR
G
S
--
NGPA
G
--
-
-
E
GY
YVA
PTL
VVNPDAKLR
L
TR
EE
V
FGPV
V
N
L
VRVADG
EEA
L
QL
AND
T
E
YGL
T
A
S
V
W
T
Q
N
L
SQ
A
L
E
Y
S
DR
L
Q
A
G
TV
WVN
SHTLIDANL
P
F
GG
M
K
Q
SG
T
G
RDF
G
PDW
L
DG
W
CET
K
S
V
C
V
fig|749533.3.peg.15
Escherichia coli MS 84-1 (5-497/499)
H
V
A
VLSQVQ
Q
F
LDR
Q
HG
L
Y
I
D
G
RPGPAQSE
---
KRLAIF
D
PAT
GQE
I
ASTAD
A
NEA
D
V
D
N
AV
M
S
A
WRA
F
VSRR
W
AGRL
P
AE
R
ERI
L
L
R
FA
D
L
V
E
QHSE
E
L
A
Q
LE
TL
E
Q
GK
SIAISRAF
E
V
GCTLNWMR
Y
T
AG
LTTKIA
G
KTLDLS
IPL
PQGARYQAWTR
K
E
P
V
GV
V
A
G
I
V
PWNFP
LM
I
GM
WK
VM
PALAAG
C
S
I
V
I
KPSE
T
TPLT
M
L
RV
A
E
L
AS
EAG
I
P
D
GV
F
NVV
T
G
S
G
AVC
G
AA
LT
S
HP
H
V
AK
I
S
F
TGS
TA
TGK
G
I
ART
A
A
D
-
HL
T
RV
T
LELGGK
N
P
A
IV
LK
D
-
AD
-----
P
Q
W
V
IEGLMTGSFL
N
Q
GQVC
AASS
R
I
YIEAPLF
D
T
L
VSGFEQAVKSL
Q
V
G
PGMSPV
-
AQI
N
PL
V
S
R
AH
C
D
K
V
CSF
L
DD
A
QAQ
Q
-
AE
L
IR
G
S
--
NGPA
G
--
-
-
E
GY
YVA
PTL
VVNPDAKLR
L
TR
EE
V
FGPV
V
N
L
VRVADG
EEA
L
QL
AND
T
E
YGL
T
A
S
V
W
T
Q
N
L
SQ
A
L
E
Y
S
DR
L
Q
A
G
TV
WVN
SHTLIDANL
P
F
GG
M
K
Q
SG
T
G
RDF
G
PDW
L
DG
W
CET
K
S
V
C
V
fig|585395.4.peg.1597
Escherichia coli O103:H2 str. 12009 (5-497/499)
H
V
A
VLSQVQ
Q
F
LDR
Q
HG
L
Y
I
D
G
RPGPAQSE
---
KRLAIF
D
PAT
GQE
I
ASTAD
A
NEA
D
V
D
N
AV
M
S
A
WRA
F
VSRR
W
AGRL
P
AE
R
ERI
L
L
R
FA
D
L
V
E
QHSE
E
L
A
Q
LE
TL
E
Q
GK
SIAISRAF
E
V
GCTLNWMR
Y
T
AG
LTTKIA
G
KTLDLS
IPL
PQGARYQAWTR
K
E
P
V
GV
V
A
G
I
V
PWNFP
LM
I
GM
WK
VM
PALAAG
C
S
I
V
I
KPSE
T
TPLT
M
L
RV
A
E
L
AS
EAG
I
P
D
GV
F
NVV
T
G
S
G
AVC
G
AA
LT
S
HP
H
V
AK
I
S
F
TGS
TA
TGK
G
I
ART
A
A
D
-
HL
T
RV
T
LELGGK
N
P
A
IV
LK
D
-
AD
-----
P
Q
W
V
IEGLMTGSFL
N
Q
GQVC
AASS
R
I
YIEAPLF
D
T
L
VSGFEQAVKSL
Q
V
G
PGMSPV
-
AQI
N
PL
V
S
R
AH
C
D
K
V
CSF
L
DD
A
QAQ
Q
-
AE
L
IR
G
S
--
NGPA
G
--
-
-
E
GY
YVA
PTL
VVNPDAKLR
L
TR
EE
V
FGPV
V
N
L
VRVADG
EEA
L
QL
AND
T
E
YGL
T
A
S
V
W
T
Q
N
L
SQ
A
L
E
Y
S
DR
L
Q
A
G
TV
WVN
SHTLIDANL
P
F
GG
M
K
Q
SG
T
G
RDF
G
PDW
L
DG
W
CET
K
S
V
C
V
fig|573235.3.peg.2021
Escherichia coli O26:H11 str. 11368 (5-497/499)
H
V
A
VLSQVQ
Q
F
LDR
Q
HG
L
Y
I
D
G
RPGPAQSE
---
KRLAIF
D
PAT
GQE
I
ASTAD
A
NEA
D
V
D
N
AV
M
S
A
WRA
F
VSRR
W
AGRL
P
AE
R
ERI
L
L
R
FA
D
L
V
E
QHSE
E
L
A
Q
LE
TL
E
Q
GK
SIAISRAF
E
V
GCTLNWMR
Y
T
AG
LTTKIA
G
KTLDLS
IPL
PQGARYQAWTR
K
E
P
V
GV
V
A
G
I
V
PWNFP
LM
I
GM
WK
VM
PALAAG
C
S
I
V
I
KPSE
T
TPLT
M
L
RV
A
E
L
AS
EAG
I
P
D
GV
F
NVV
T
G
S
G
AVC
G
AA
LT
S
HP
H
V
AK
I
S
F
TGS
TA
TGK
G
I
ART
A
A
D
-
HL
T
RV
T
LELGGK
N
P
A
IV
LK
D
-
AD
-----
P
Q
W
V
IEGLMTGSFL
N
Q
GQVC
AASS
R
I
YIEAPLF
D
T
L
VSGFEQAVKSL
Q
V
G
PGMSPV
-
AQI
N
PL
V
S
R
AH
C
D
K
V
CSF
L
DD
A
QAQ
Q
-
AE
L
IR
G
S
--
NGPA
G
--
-
-
E
GY
YVA
PTL
VVNPDAKLR
L
TR
EE
V
FGPV
V
N
L
VRVADG
EEA
L
QL
AND
T
E
YGL
T
A
S
V
W
T
Q
N
L
SQ
A
L
E
Y
S
DR
L
Q
A
G
TV
WVN
SHTLIDANL
P
F
GG
M
K
Q
SG
T
G
RDF
G
PDW
L
DG
W
CET
K
S
V
C
V
fig|409438.11.peg.1612
Escherichia coli SE11 (5-497/499)
H
V
A
VLSQVQ
Q
F
LDR
Q
HG
L
Y
I
D
G
RPGPAQSE
---
KRLAIF
D
PAT
GQE
I
ASTAD
A
NEA
D
V
D
N
AV
M
S
A
WRA
F
VSRR
W
AGRL
P
AE
R
ERI
L
L
R
FA
D
L
V
E
QHSE
E
L
A
Q
LE
TL
E
Q
GK
SIAISRAF
E
V
GCTLNWMR
Y
T
AG
LTTKIA
G
KTLDLS
IPL
PQGARYQAWTR
K
E
P
V
GV
V
A
G
I
V
PWNFP
LM
I
GM
WK
VM
PALAAG
C
S
I
V
I
KPSE
T
TPLT
M
L
RV
A
E
L
AS
EAG
I
P
D
GV
F
NVV
T
G
S
G
AVC
G
AA
LT
S
HP
H
V
AK
I
S
F
TGS
TA
TGK
G
I
ART
A
A
D
-
HL
T
RV
T
LELGGK
N
P
A
IV
LK
D
-
AD
-----
P
Q
W
V
IEGLMTGSFL
N
Q
GQVC
AASS
R
I
YIEAPLF
D
T
L
VSGFEQAVKSL
Q
V
G
PGMSPV
-
AQI
N
PL
V
S
R
AH
C
D
K
V
CSF
L
DD
A
QAQ
Q
-
AE
L
IR
G
S
--
NGPA
G
--
-
-
E
GY
YVA
PTL
VVNPDAKLR
L
TR
EE
V
FGPV
V
N
L
VRVADG
EEA
L
QL
AND
T
E
YGL
T
A
S
V
W
T
Q
N
L
SQ
A
L
E
Y
S
DR
L
Q
A
G
TV
WVN
SHTLIDANL
P
F
GG
M
K
Q
SG
T
G
RDF
G
PDW
L
DG
W
CET
K
S
V
C
V
fig|656443.3.peg.1708
Escherichia coli TA271 (5-497/499)
H
V
A
VLSQVQ
Q
F
LDR
Q
HG
L
Y
I
D
G
RPGPAQSE
---
KRLAIF
D
PAT
GQE
I
ASTAD
A
NEA
D
V
D
N
AV
M
S
A
WRA
F
VSRR
W
AGRL
P
AE
R
ERI
L
L
R
FA
D
L
V
E
QHSE
E
L
A
Q
LE
TL
E
Q
GK
SIAISRAF
E
V
GCTLNWMR
Y
T
AG
LTTKIA
G
KTLDLS
IPL
PQGARYQAWTR
K
E
P
V
GV
V
A
G
I
V
PWNFP
LM
I
GM
WK
VM
PALAAG
C
S
I
V
I
KPSE
T
TPLT
M
L
RV
A
E
L
AS
EAG
I
P
D
GV
F
NVV
T
G
S
G
AVC
G
AA
LT
S
HP
H
V
AK
I
S
F
TGS
TA
TGK
G
I
ART
A
A
D
-
HL
T
RV
T
LELGGK
N
P
A
IV
LK
D
-
AD
-----
P
Q
W
V
IEGLMTGSFL
N
Q
GQVC
AASS
R
I
YIEAPLF
D
T
L
VSGFEQAVKSL
Q
V
G
PGMSPV
-
AQI
N
PL
V
S
R
AH
C
D
K
V
CSF
L
DD
A
QAQ
Q
-
AE
L
IR
G
S
--
NGPA
G
--
-
-
E
GY
YVA
PTL
VVNPDAKLR
L
TR
EE
V
FGPV
V
N
L
VRVADG
EEA
L
QL
AND
T
E
YGL
T
A
S
V
W
T
Q
N
L
SQ
A
L
E
Y
S
DR
L
Q
A
G
TV
WVN
SHTLIDANL
P
F
GG
M
K
Q
SG
T
G
RDF
G
PDW
L
DG
W
CET
K
S
V
C
V
fig|316407.3.peg.1348
Escherichia coli W3110 (5-497/499)
H
V
A
VLSQVQ
Q
F
LDR
Q
HG
L
Y
I
D
G
RPGPAQSE
---
KRLAIF
D
PAT
GQE
I
ASTAD
A
NEA
D
V
D
N
AV
M
S
A
WRA
F
VSRR
W
AGRL
P
AE
R
ERI
L
L
R
FA
D
L
V
E
QHSE
E
L
A
Q
LE
TL
E
Q
GK
SIAISRAF
E
V
GCTLNWMR
Y
T
AG
LTTKIA
G
KTLDLS
IPL
PQGARYQAWTR
K
E
P
V
GV
V
A
G
I
V
PWNFP
LM
I
GM
WK
VM
PALAAG
C
S
I
V
I
KPSE
T
TPLT
M
L
RV
A
E
L
AS
EAG
I
P
D
GV
F
NVV
T
G
S
G
AVC
G
AA
LT
S
HP
H
V
AK
I
S
F
TGS
TA
TGK
G
I
ART
A
A
D
-
HL
T
RV
T
LELGGK
N
P
A
IV
LK
D
-
AD
-----
P
Q
W
V
IEGLMTGSFL
N
Q
GQVC
AASS
R
I
YIEAPLF
D
T
L
VSGFEQAVKSL
Q
V
G
PGMSPV
-
AQI
N
PL
V
S
R
AH
C
D
K
V
CSF
L
DD
A
QAQ
Q
-
AE
L
IR
G
S
--
NGPA
G
--
-
-
E
GY
YVA
PTL
VVNPDAKLR
L
TR
EE
V
FGPV
V
N
L
VRVADG
EEA
L
QL
AND
T
E
YGL
T
A
S
V
W
T
Q
N
L
SQ
A
L
E
Y
S
DR
L
Q
A
G
TV
WVN
SHTLIDANL
P
F
GG
M
K
Q
SG
T
G
RDF
G
PDW
L
DG
W
CET
K
S
V
C
V
fig|316385.5.peg.1494
Escherichia coli str. K-12 substr. DH10B (5-497/499)
H
V
A
VLSQVQ
Q
F
LDR
Q
HG
L
Y
I
D
G
RPGPAQSE
---
KRLAIF
D
PAT
GQE
I
ASTAD
A
NEA
D
V
D
N
AV
M
S
A
WRA
F
VSRR
W
AGRL
P
AE
R
ERI
L
L
R
FA
D
L
V
E
QHSE
E
L
A
Q
LE
TL
E
Q
GK
SIAISRAF
E
V
GCTLNWMR
Y
T
AG
LTTKIA
G
KTLDLS
IPL
PQGARYQAWTR
K
E
P
V
GV
V
A
G
I
V
PWNFP
LM
I
GM
WK
VM
PALAAG
C
S
I
V
I
KPSE
T
TPLT
M
L
RV
A
E
L
AS
EAG
I
P
D
GV
F
NVV
T
G
S
G
AVC
G
AA
LT
S
HP
H
V
AK
I
S
F
TGS
TA
TGK
G
I
ART
A
A
D
-
HL
T
RV
T
LELGGK
N
P
A
IV
LK
D
-
AD
-----
P
Q
W
V
IEGLMTGSFL
N
Q
GQVC
AASS
R
I
YIEAPLF
D
T
L
VSGFEQAVKSL
Q
V
G
PGMSPV
-
AQI
N
PL
V
S
R
AH
C
D
K
V
CSF
L
DD
A
QAQ
Q
-
AE
L
IR
G
S
--
NGPA
G
--
-
-
E
GY
YVA
PTL
VVNPDAKLR
L
TR
EE
V
FGPV
V
N
L
VRVADG
EEA
L
QL
AND
T
E
YGL
T
A
S
V
W
T
Q
N
L
SQ
A
L
E
Y
S
DR
L
Q
A
G
TV
WVN
SHTLIDANL
P
F
GG
M
K
Q
SG
T
G
RDF
G
PDW
L
DG
W
CET
K
S
V
C
V
fig|316385.7.peg.1536
Escherichia coli str. K-12 substr. DH10B (5-497/499)
H
V
A
VLSQVQ
Q
F
LDR
Q
HG
L
Y
I
D
G
RPGPAQSE
---
KRLAIF
D
PAT
GQE
I
ASTAD
A
NEA
D
V
D
N
AV
M
S
A
WRA
F
VSRR
W
AGRL
P
AE
R
ERI
L
L
R
FA
D
L
V
E
QHSE
E
L
A
Q
LE
TL
E
Q
GK
SIAISRAF
E
V
GCTLNWMR
Y
T
AG
LTTKIA
G
KTLDLS
IPL
PQGARYQAWTR
K
E
P
V
GV
V
A
G
I
V
PWNFP
LM
I
GM
WK
VM
PALAAG
C
S
I
V
I
KPSE
T
TPLT
M
L
RV
A
E
L
AS
EAG
I
P
D
GV
F
NVV
T
G
S
G
AVC
G
AA
LT
S
HP
H
V
AK
I
S
F
TGS
TA
TGK
G
I
ART
A
A
D
-
HL
T
RV
T
LELGGK
N
P
A
IV
LK
D
-
AD
-----
P
Q
W
V
IEGLMTGSFL
N
Q
GQVC
AASS
R
I
YIEAPLF
D
T
L
VSGFEQAVKSL
Q
V
G
PGMSPV
-
AQI
N
PL
V
S
R
AH
C
D
K
V
CSF
L
DD
A
QAQ
Q
-
AE
L
IR
G
S
--
NGPA
G
--
-
-
E
GY
YVA
PTL
VVNPDAKLR
L
TR
EE
V
FGPV
V
N
L
VRVADG
EEA
L
QL
AND
T
E
YGL
T
A
S
V
W
T
Q
N
L
SQ
A
L
E
Y
S
DR
L
Q
A
G
TV
WVN
SHTLIDANL
P
F
GG
M
K
Q
SG
T
G
RDF
G
PDW
L
DG
W
CET
K
S
V
C
V
fig|511145.12.peg.1448
Escherichia coli str. K-12 substr. MG1655 (5-497/499)
H
V
A
VLSQVQ
Q
F
LDR
Q
HG
L
Y
I
D
G
RPGPAQSE
---
KRLAIF
D
PAT
GQE
I
ASTAD
A
NEA
D
V
D
N
AV
M
S
A
WRA
F
VSRR
W
AGRL
P
AE
R
ERI
L
L
R
FA
D
L
V
E
QHSE
E
L
A
Q
LE
TL
E
Q
GK
SIAISRAF
E
V
GCTLNWMR
Y
T
AG
LTTKIA
G
KTLDLS
IPL
PQGARYQAWTR
K
E
P
V
GV
V
A
G
I
V
PWNFP
LM
I
GM
WK
VM
PALAAG
C
S
I
V
I
KPSE
T
TPLT
M
L
RV
A
E
L
AS
EAG
I
P
D
GV
F
NVV
T
G
S
G
AVC
G
AA
LT
S
HP
H
V
AK
I
S
F
TGS
TA
TGK
G
I
ART
A
A
D
-
HL
T
RV
T
LELGGK
N
P
A
IV
LK
D
-
AD
-----
P
Q
W
V
IEGLMTGSFL
N
Q
GQVC
AASS
R
I
YIEAPLF
D
T
L
VSGFEQAVKSL
Q
V
G
PGMSPV
-
AQI
N
PL
V
S
R
AH
C
D
K
V
CSF
L
DD
A
QAQ
Q
-
AE
L
IR
G
S
--
NGPA
G
--
-
-
E
GY
YVA
PTL
VVNPDAKLR
L
TR
EE
V
FGPV
V
N
L
VRVADG
EEA
L
QL
AND
T
E
YGL
T
A
S
V
W
T
Q
N
L
SQ
A
L
E
Y
S
DR
L
Q
A
G
TV
WVN
SHTLIDANL
P
F
GG
M
K
Q
SG
T
G
RDF
G
PDW
L
DG
W
CET
K
S
V
C
V
fig|511145.6.peg.1435
Escherichia coli str. K-12 substr. MG1655 (5-497/499)
H
V
A
VLSQVQ
Q
F
LDR
Q
HG
L
Y
I
D
G
RPGPAQSE
---
KRLAIF
D
PAT
GQE
I
ASTAD
A
NEA
D
V
D
N
AV
M
S
A
WRA
F
VSRR
W
AGRL
P
AE
R
ERI
L
L
R
FA
D
L
V
E
QHSE
E
L
A
Q
LE
TL
E
Q
GK
SIAISRAF
E
V
GCTLNWMR
Y
T
AG
LTTKIA
G
KTLDLS
IPL
PQGARYQAWTR
K
E
P
V
GV
V
A
G
I
V
PWNFP
LM
I
GM
WK
VM
PALAAG
C
S
I
V
I
KPSE
T
TPLT
M
L
RV
A
E
L
AS
EAG
I
P
D
GV
F
NVV
T
G
S
G
AVC
G
AA
LT
S
HP
H
V
AK
I
S
F
TGS
TA
TGK
G
I
ART
A
A
D
-
HL
T
RV
T
LELGGK
N
P
A
IV
LK
D
-
AD
-----
P
Q
W
V
IEGLMTGSFL
N
Q
GQVC
AASS
R
I
YIEAPLF
D
T
L
VSGFEQAVKSL
Q
V
G
PGMSPV
-
AQI
N
PL
V
S
R
AH
C
D
K
V
CSF
L
DD
A
QAQ
Q
-
AE
L
IR
G
S
--
NGPA
G
--
-
-
E
GY
YVA
PTL
VVNPDAKLR
L
TR
EE
V
FGPV
V
N
L
VRVADG
EEA
L
QL
AND
T
E
YGL
T
A
S
V
W
T
Q
N
L
SQ
A
L
E
Y
S
DR
L
Q
A
G
TV
WVN
SHTLIDANL
P
F
GG
M
K
Q
SG
T
G
RDF
G
PDW
L
DG
W
CET
K
S
V
C
V
fig|595495.4.peg.960
Escherichia coli KO11 (5-497/499)
H
V
A
VLSQVQ
Q
F
LDR
Q
HG
L
Y
I
D
G
RPGPAQSE
---
KRLAIF
D
PAT
GQE
I
ASTAD
A
NEA
D
V
D
N
AV
M
S
A
WRA
F
VSRR
W
AGRL
P
AE
R
ERI
L
L
R
FA
D
L
V
E
QHSE
E
L
A
Q
LE
TL
E
Q
GK
SIAISRAF
E
V
GCTLNWMR
Y
T
AG
LTTKIA
G
KTLDLS
IPL
PQGARYQAWTR
K
E
P
V
GV
V
A
G
I
V
PWNFP
LM
I
GM
WK
VM
PALAAG
C
S
I
V
I
KPSE
T
TPLT
M
L
RV
A
E
L
AS
EAG
I
P
D
GV
F
NVV
T
G
S
G
AVC
G
AA
LT
S
HP
H
V
AK
I
S
F
TGS
TA
TGK
G
I
ART
A
A
D
-
R
L
T
RV
T
LELGGK
N
P
A
IV
LK
D
-
AD
-----
P
Q
W
V
IEGLMTGSFL
N
Q
GQVC
AASS
R
I
YIEAPLF
D
T
L
VSGFEQAVKSL
Q
V
G
PGMSPV
-
AQI
N
PL
V
S
R
AH
C
D
K
V
CSF
L
DD
A
QAQ
Q
-
AE
L
IR
G
S
--
NGPA
G
--
-
-
E
GY
YVA
PTL
VVNPDAKLR
L
TR
EE
V
FGPV
V
N
L
VRVADG
EEA
L
QL
AND
T
E
YGL
T
A
S
V
W
T
Q
N
L
SQ
A
L
E
Y
S
DR
L
Q
A
G
TV
WVN
SHTLIDANL
P
F
GG
M
K
Q
SG
T
G
RDF
G
PDW
L
DG
W
CET
K
S
V
C
V
fig|566546.3.peg.76
Escherichia coli W (5-497/499)
H
V
A
VLSQVQ
Q
F
LDR
Q
HG
L
Y
I
D
G
RPGPAQSE
---
KRLAIF
D
PAT
GQE
I
ASTAD
A
NEA
D
V
D
N
AV
M
S
A
WRA
F
VSRR
W
AGRL
P
AE
R
ERI
L
L
R
FA
D
L
V
E
QHSE
E
L
A
Q
LE
TL
E
Q
GK
SIAISRAF
E
V
GCTLNWMR
Y
T
AG
LTTKIA
G
KTLDLS
IPL
PQGARYQAWTR
K
E
P
V
GV
V
A
G
I
V
PWNFP
LM
I
GM
WK
VM
PALAAG
C
S
I
V
I
KPSE
T
TPLT
M
L
RV
A
E
L
AS
EAG
I
P
D
GV
F
NVV
T
G
S
G
AVC
G
AA
LT
S
HP
H
V
AK
I
S
F
TGS
TA
TGK
G
I
ART
A
A
D
-
R
L
T
RV
T
LELGGK
N
P
A
IV
LK
D
-
AD
-----
P
Q
W
V
IEGLMTGSFL
N
Q
GQVC
AASS
R
I
YIEAPLF
D
T
L
VSGFEQAVKSL
Q
V
G
PGMSPV
-
AQI
N
PL
V
S
R
AH
C
D
K
V
CSF
L
DD
A
QAQ
Q
-
AE
L
IR
G
S
--
NGPA
G
--
-
-
E
GY
YVA
PTL
VVNPDAKLR
L
TR
EE
V
FGPV
V
N
L
VRVADG
EEA
L
QL
AND
T
E
YGL
T
A
S
V
W
T
Q
N
L
SQ
A
L
E
Y
S
DR
L
Q
A
G
TV
WVN
SHTLIDANL
P
F
GG
M
K
Q
SG
T
G
RDF
G
PDW
L
DG
W
CET
K
S
V
C
V
fig|566546.4.peg.1505
Escherichia coli W (5-497/499)
H
V
A
VLSQVQ
Q
F
LDR
Q
HG
L
Y
I
D
G
RPGPAQSE
---
KRLAIF
D
PAT
GQE
I
ASTAD
A
NEA
D
V
D
N
AV
M
S
A
WRA
F
VSRR
W
AGRL
P
AE
R
ERI
L
L
R
FA
D
L
V
E
QHSE
E
L
A
Q
LE
TL
E
Q
GK
SIAISRAF
E
V
GCTLNWMR
Y
T
AG
LTTKIA
G
KTLDLS
IPL
PQGARYQAWTR
K
E
P
V
GV
V
A
G
I
V
PWNFP
LM
I
GM
WK
VM
PALAAG
C
S
I
V
I
KPSE
T
TPLT
M
L
RV
A
E
L
AS
EAG
I
P
D
GV
F
NVV
T
G
S
G
AVC
G
AA
LT
S
HP
H
V
AK
I
S
F
TGS
TA
TGK
G
I
ART
A
A
D
-
R
L
T
RV
T
LELGGK
N
P
A
IV
LK
D
-
AD
-----
P
Q
W
V
IEGLMTGSFL
N
Q
GQVC
AASS
R
I
YIEAPLF
D
T
L
VSGFEQAVKSL
Q
V
G
PGMSPV
-
AQI
N
PL
V
S
R
AH
C
D
K
V
CSF
L
DD
A
QAQ
Q
-
AE
L
IR
G
S
--
NGPA
G
--
-
-
E
GY
YVA
PTL
VVNPDAKLR
L
TR
EE
V
FGPV
V
N
L
VRVADG
EEA
L
QL
AND
T
E
YGL
T
A
S
V
W
T
Q
N
L
SQ
A
L
E
Y
S
DR
L
Q
A
G
TV
WVN
SHTLIDANL
P
F
GG
M
K
Q
SG
T
G
RDF
G
PDW
L
DG
W
CET
K
S
V
C
V
fig|679207.4.peg.4621
Escherichia coli MS 107-1 (5-497/499)
H
V
A
VLSQVQ
Q
F
LDR
Q
HG
L
Y
I
D
G
RPGPAQSE
---
KRLAIF
D
PAT
GQE
I
ASTAD
A
NEA
D
V
D
N
AV
M
S
A
WRA
F
VSRR
W
AGRL
P
AE
R
ERI
L
L
R
FA
D
L
V
E
QHSE
E
L
A
Q
LE
TL
E
Q
GK
SIAISRAF
E
V
GCTLNWMR
Y
T
AG
LTTKIA
G
KTLDLS
IPL
PQGARYQAWTR
K
E
P
V
GV
V
A
G
I
V
PWNFP
LM
I
GM
WK
VM
PALAAG
C
S
I
V
I
KPSE
T
TPLT
M
L
RV
A
E
L
AS
EAG
I
P
D
GV
F
NVV
T
G
S
G
AVC
G
AA
LT
S
HP
H
V
AK
I
S
F
TGS
TA
TGK
G
I
ART
A
A
D
-
R
L
T
RV
T
LELGGK
N
P
A
IV
LK
D
-
AD
-----
P
Q
W
V
IEGLMTGSFL
N
Q
GQVC
AASS
R
I
YIEAPLF
D
T
L
VSGFEQAVKSL
Q
V
G
PGMSPV
-
AQI
N
PL
V
S
R
AH
C
D
K
V
CSF
L
DD
A
QAQ
Q
-
AE
L
IR
G
L
--
NGPA
G
--
-
-
E
GY
YVA
PTL
VVNPDAKLR
L
TR
EE
V
FGPV
V
N
L
VRVADG
EEA
L
QL
AND
T
E
YGL
T
A
S
V
W
T
Q
N
L
SQ
A
L
E
Y
S
DR
L
Q
A
G
TV
WVN
SHTLIDANL
P
F
GG
M
K
Q
SG
T
G
RDF
G
PDW
L
DS
W
RET
K
S
V
C
V
fig|1040638.4.peg.4123
Escherichia coli O104:H4 str. LB226692 (5-497/499)
H
V
A
VLSQVQ
Q
F
LDR
Q
HG
L
Y
I
D
G
RPGPAQSE
---
KRLAIF
D
PAT
GQE
I
ASTAD
A
NEA
D
V
D
N
AV
M
S
A
WRA
F
VSRR
W
AGRL
P
AE
R
ERI
L
L
R
FA
D
L
V
E
QHSE
E
L
A
Q
LE
TL
E
Q
GK
SIAISRAF
E
V
GCTLNWMR
Y
T
AG
LTTKIA
G
KTLDLS
IPL
PQGARYQAWTR
K
E
P
V
GV
V
A
G
I
V
PWNFP
LM
I
GM
WK
VM
PALAAG
C
S
I
V
I
KPSE
T
TPLT
M
L
RV
A
E
L
AS
EAG
I
P
D
GV
F
NVV
T
G
S
G
AVC
G
AA
LT
S
HP
H
V
AK
I
S
F
TGS
TA
TGK
G
I
ART
A
A
D
-
HL
T
RV
T
LELGGK
N
P
A
IV
LK
D
-
AD
-----
P
Q
W
V
IEGLMTGSFL
N
Q
GQVC
AASS
R
I
YIEAPLF
D
T
L
VSGFEQAVKSL
Q
V
G
PGMSPV
-
AQI
N
P
V
V
S
R
AH
C
D
K
V
CSF
L
DD
A
QAQ
Q
-
AE
L
IR
G
S
--
NGPA
G
--
-
-
E
GY
YVA
PTL
VVNPDAKLR
L
TR
EE
V
FGPV
V
N
L
VRVADG
EEA
L
QL
AND
T
E
YGL
T
A
S
V
W
T
Q
N
L
SQ
A
L
E
Y
S
DR
L
Q
A
G
TV
WVN
SHTLIDANL
P
F
GG
M
K
Q
SG
T
G
RDF
G
PDW
L
DG
W
CET
K
S
V
C
V
fig|6666666.5357.peg.3644
Escherichia coli TY-2482 (5-497/499)
H
V
A
VLSQVQ
Q
F
LDR
Q
HG
L
Y
I
D
G
RPGPAQSE
---
KRLAIF
D
PAT
GQE
I
ASTAD
A
NEA
D
V
D
N
AV
M
S
A
WRA
F
VSRR
W
AGRL
P
AE
R
ERI
L
L
R
FA
D
L
V
E
QHSE
E
L
A
Q
LE
TL
E
Q
GK
SIAISRAF
E
V
GCTLNWMR
Y
T
AG
LTTKIA
G
KTLDLS
IPL
PQGARYQAWTR
K
E
P
V
GV
V
A
G
I
V
PWNFP
LM
I
GM
WK
VM
PALAAG
C
S
I
V
I
KPSE
T
TPLT
M
L
RV
A
E
L
AS
EAG
I
P
D
GV
F
NVV
T
G
S
G
AVC
G
AA
LT
S
HP
H
V
AK
I
S
F
TGS
TA
TGK
G
I
ART
A
A
D
-
HL
T
RV
T
LELGGK
N
P
A
IV
LK
D
-
AD
-----
P
Q
W
V
IEGLMTGSFL
N
Q
GQVC
AASS
R
I
YIEAPLF
D
T
L
VSGFEQAVKSL
Q
V
G
PGMSPV
-
AQI
N
P
V
V
S
R
AH
C
D
K
V
CSF
L
DD
A
QAQ
Q
-
AE
L
IR
G
S
--
NGPA
G
--
-
-
E
GY
YVA
PTL
VVNPDAKLR
L
TR
EE
V
FGPV
V
N
L
VRVADG
EEA
L
QL
AND
T
E
YGL
T
A
S
V
W
T
Q
N
L
SQ
A
L
E
Y
S
DR
L
Q
A
G
TV
WVN
SHTLIDANL
P
F
GG
M
K
Q
SG
T
G
RDF
G
PDW
L
DG
W
CET
K
S
V
C
V
fig|585055.6.peg.1551
Escherichia coli 55989 (5-497/499)
H
V
A
VLSQVQ
Q
F
LDR
Q
HG
L
Y
I
D
G
RPGPAQSE
---
KRLAIF
D
PAT
GQE
I
ASTAD
A
NEA
D
V
D
N
AV
M
S
A
WRA
F
VSRR
W
AGRL
P
AE
R
ERI
L
L
R
FA
D
L
V
E
QHSE
E
L
A
Q
LE
TL
E
Q
GK
SIAISRAF
E
V
GCTLNWMR
Y
T
AG
LTTKIA
G
KTLDLS
IPL
PQGARYQAWTR
K
E
P
V
GV
V
A
G
I
V
PWNFP
LM
I
GM
WK
VM
PALAAG
C
S
I
V
I
KPSE
T
TPLT
M
L
RV
A
E
L
AS
EAG
I
P
D
GV
F
NVV
T
G
S
G
AVC
G
AA
LT
S
HP
H
V
AK
I
S
F
TGS
TA
TGK
G
I
ART
A
A
D
-
HL
T
RV
T
LELGGK
N
P
A
IV
LK
D
-
AD
-----
P
Q
W
V
IEGLMTGSFL
N
Q
GQVC
AASS
R
I
YIEAPLF
D
T
L
VSGFEQAVKSL
Q
V
G
PGMSPV
-
AQI
N
P
V
V
S
R
AH
C
D
K
V
CSF
L
DD
A
QAQ
Q
-
AE
L
IR
G
S
--
NGPA
G
--
-
-
E
GY
YVA
PTL
VVNPDAKLR
L
TR
EE
V
FGPV
V
N
L
VRVADG
EEA
L
QL
AND
T
E
YGL
T
A
S
V
W
T
Q
N
L
SQ
A
L
E
Y
S
DR
L
Q
A
G
TV
WVN
SHTLIDANL
P
F
GG
M
K
Q
SG
T
G
RDF
G
PDW
L
DG
W
CET
K
S
V
C
V
fig|585055.8.peg.1552
Escherichia coli 55989 (5-497/499)
H
V
A
VLSQVQ
Q
F
LDR
Q
HG
L
Y
I
D
G
RPGPAQSE
---
KRLAIF
D
PAT
GQE
I
ASTAD
A
NEA
D
V
D
N
AV
M
S
A
WRA
F
VSRR
W
AGRL
P
AE
R
ERI
L
L
R
FA
D
L
V
E
QHSE
E
L
A
Q
LE
TL
E
Q
GK
SIAISRAF
E
V
GCTLNWMR
Y
T
AG
LTTKIA
G
KTLDLS
IPL
PQGARYQAWTR
K
E
P
V
GV
V
A
G
I
V
PWNFP
LM
I
GM
WK
VM
PALAAG
C
S
I
V
I
KPSE
T
TPLT
M
L
RV
A
E
L
AS
EAG
I
P
D
GV
F
NVV
T
G
S
G
AVC
G
AA
LT
S
HP
H
V
AK
I
S
F
TGS
TA
TGK
G
I
ART
A
A
D
-
HL
T
RV
T
LELGGK
N
P
A
IV
LK
D
-
AD
-----
P
Q
W
V
IEGLMTGSFL
N
Q
GQVC
AASS
R
I
YIEAPLF
D
T
L
VSGFEQAVKSL
Q
V
G
PGMSPV
-
AQI
N
P
V
V
S
R
AH
C
D
K
V
CSF
L
DD
A
QAQ
Q
-
AE
L
IR
G
S
--
NGPA
G
--
-
-
E
GY
YVA
PTL
VVNPDAKLR
L
TR
EE
V
FGPV
V
N
L
VRVADG
EEA
L
QL
AND
T
E
YGL
T
A
S
V
W
T
Q
N
L
SQ
A
L
E
Y
S
DR
L
Q
A
G
TV
WVN
SHTLIDANL
P
F
GG
M
K
Q
SG
T
G
RDF
G
PDW
L
DG
W
CET
K
S
V
C
V
fig|585034.4.peg.1375
Escherichia coli IAI1 (5-497/499)
H
V
A
VLSQVQ
Q
F
LDR
Q
HG
L
Y
I
D
G
RPGPAQSE
---
KRLAIF
D
PAT
GQE
I
ASTAD
A
NEA
D
V
D
N
AV
M
S
A
WRA
F
VSRR
W
AGRL
P
AE
R
ERI
L
L
R
FA
D
L
V
E
QHSE
E
L
A
Q
LE
TL
E
Q
GK
SIAISRAF
E
V
GCTLNWMR
Y
T
AG
LTTKIA
G
KTLDLS
IPL
PQGARYQAWTR
K
E
P
V
GV
V
A
G
I
V
PWNFP
LM
I
GM
WK
VM
PALAAG
C
S
I
V
I
KPSE
T
TPLT
M
L
RV
A
E
L
AS
EAG
I
P
D
GV
F
NVV
T
G
S
G
AVC
G
AA
LT
S
HP
H
V
AK
I
S
F
TGS
TA
TGK
G
I
ART
A
A
D
-
HL
T
RV
T
LELGGK
N
P
A
IV
LK
D
-
AD
-----
P
Q
W
V
IEGLMTGSFL
N
Q
GQVC
AASS
R
I
YIEAPLF
D
T
L
VSGFEQAVKSL
Q
V
G
PGMSPV
-
AQI
N
P
V
V
S
R
AH
C
D
K
V
CSF
L
DD
A
QAQ
Q
-
AE
L
IR
G
S
--
NGPA
G
--
-
-
E
GY
YVA
PTL
VVNPDAKLR
L
TR
EE
V
FGPV
V
N
L
VRVADG
EEA
L
QL
AND
T
E
YGL
T
A
S
V
W
T
Q
N
L
SQ
A
L
E
Y
S
DR
L
Q
A
G
TV
WVN
SHTLIDANL
P
F
GG
M
K
Q
SG
T
G
RDF
G
PDW
L
DG
W
CET
K
S
V
C
V
fig|585034.5.peg.1371
Escherichia coli IAI1 (5-497/499)
H
V
A
VLSQVQ
Q
F
LDR
Q
HG
L
Y
I
D
G
RPGPAQSE
---
KRLAIF
D
PAT
GQE
I
ASTAD
A
NEA
D
V
D
N
AV
M
S
A
WRA
F
VSRR
W
AGRL
P
AE
R
ERI
L
L
R
FA
D
L
V
E
QHSE
E
L
A
Q
LE
TL
E
Q
GK
SIAISRAF
E
V
GCTLNWMR
Y
T
AG
LTTKIA
G
KTLDLS
IPL
PQGARYQAWTR
K
E
P
V
GV
V
A
G
I
V
PWNFP
LM
I
GM
WK
VM
PALAAG
C
S
I
V
I
KPSE
T
TPLT
M
L
RV
A
E
L
AS
EAG
I
P
D
GV
F
NVV
T
G
S
G
AVC
G
AA
LT
S
HP
H
V
AK
I
S
F
TGS
TA
TGK
G
I
ART
A
A
D
-
HL
T
RV
T
LELGGK
N
P
A
IV
LK
D
-
AD
-----
P
Q
W
V
IEGLMTGSFL
N
Q
GQVC
AASS
R
I
YIEAPLF
D
T
L
VSGFEQAVKSL
Q
V
G
PGMSPV
-
AQI
N
P
V
V
S
R
AH
C
D
K
V
CSF
L
DD
A
QAQ
Q
-
AE
L
IR
G
S
--
NGPA
G
--
-
-
E
GY
YVA
PTL
VVNPDAKLR
L
TR
EE
V
FGPV
V
N
L
VRVADG
EEA
L
QL
AND
T
E
YGL
T
A
S
V
W
T
Q
N
L
SQ
A
L
E
Y
S
DR
L
Q
A
G
TV
WVN
SHTLIDANL
P
F
GG
M
K
Q
SG
T
G
RDF
G
PDW
L
DG
W
CET
K
S
V
C
V
fig|749531.3.peg.399
Escherichia coli MS 69-1 (5-497/499)
H
V
A
VLSQVQ
Q
F
LDR
Q
HG
L
Y
I
D
G
RPGPAQSE
---
KRLAIF
D
PAT
GQE
I
ASTAD
A
NEA
D
V
D
N
AV
M
S
A
WRA
F
VSRR
W
AGRL
P
AE
R
ERI
L
L
R
FA
D
L
V
E
QHSE
E
L
A
Q
LE
TL
E
Q
GK
SIAISRAF
E
V
GCTLNWMR
Y
T
AG
LTTKIA
G
KTLDLS
IPL
PQGARYQAWTR
K
E
P
V
GV
V
A
G
I
V
PWNFP
LM
I
GM
WK
VM
PALAAG
C
S
I
V
I
KPSE
T
TPLT
M
L
RV
A
E
L
AS
EAG
I
P
D
GV
F
NVV
T
G
S
G
SVC
G
AA
LT
S
HP
H
V
AK
I
S
F
TGS
TA
TGK
G
I
ART
A
A
D
-
R
L
T
RV
T
LELGGK
N
P
A
IV
LK
D
-
AD
-----
P
Q
W
V
IEGLMTGSFL
N
Q
GQVC
AASS
R
I
YIEAPLF
D
T
L
VSGFEQAVKSL
Q
V
G
PGMSPV
-
AQI
N
PL
V
S
R
AH
C
D
K
V
RSF
L
DD
A
QAQ
Q
-
AE
L
IR
G
A
--
SGPA
G
--
-
-
E
GY
YVA
PTL
VVNPDAKLR
L
TR
EE
V
FGPV
V
N
L
VRVADG
EEA
L
QL
AND
T
E
YGL
T
A
S
V
W
T
Q
N
L
SQ
A
L
E
Y
S
DR
L
Q
A
G
TV
WVN
SHTLIDANL
P
F
GG
M
K
Q
SG
T
G
RDF
G
PDW
L
DG
W
CET
K
S
V
C
V
fig|562.375.peg.4267
Escherichia coli EC4100B (5-497/499)
H
V
A
VLSQVQ
Q
F
LDR
Q
HG
L
Y
I
D
G
RPGPAQSE
---
KRLAIF
D
PAT
GQE
I
ASTAD
A
NEA
D
V
D
N
AV
M
S
A
WRA
F
VSRR
W
AGRL
P
AE
R
ERI
L
L
R
FA
D
L
V
E
QHSE
E
L
A
Q
LE
TL
E
Q
GK
SIAISRAF
E
V
GCTLNWMR
Y
T
AG
LTTKIA
G
KTLDLS
IPL
PQGARYQAWTR
K
E
P
V
GV
V
A
G
I
V
PWNFP
LM
I
GM
WK
VM
PALAAG
C
S
I
V
I
KPSE
T
TPLT
M
L
RV
A
E
L
AS
EAG
I
P
D
GV
F
NVV
T
G
S
G
AVC
G
AA
LT
S
HP
H
V
AK
I
S
F
TGS
TA
TGK
G
I
ART
A
A
D
-
HL
T
H
V
T
LELGGK
N
P
A
IV
LK
D
-
AD
-----
P
Q
W
V
IEGLMTGSFL
N
Q
GQVC
AASS
R
I
YIEAPLF
D
T
L
VSGFEQAVKSL
Q
V
G
PGMSPV
-
AQI
N
PL
V
S
R
AH
C
D
K
V
CSF
L
DD
A
QAQ
Q
-
AE
L
IR
G
S
--
NGPA
G
--
-
-
E
GY
YVA
PTL
VVNPDAKLR
L
TR
EE
V
FGPV
V
N
L
VRVADG
EEA
L
QL
AND
T
E
YGL
T
A
S
V
W
T
Q
N
L
SQ
A
L
E
Y
S
DR
L
Q
A
G
TV
WVN
SHTLIDANL
P
F
GG
M
K
Q
SG
T
G
RDF
G
PDW
L
DG
W
CET
K
S
V
C
V
fig|670888.3.peg.2052
Escherichia coli 1827-70 (5-497/499)
H
V
A
VLSQVQ
Q
F
LDR
Q
HG
L
Y
I
D
G
RPGPAQSE
---
KRLAIF
D
PAT
GQE
I
ASTAD
A
NEA
D
V
D
N
AV
M
S
A
WRA
F
VSRR
W
AGRL
P
AE
R
ERI
L
L
R
FA
D
L
V
E
QHSE
E
L
A
Q
LE
TL
E
Q
GK
SIAISRAF
E
V
GCTLNWMR
Y
T
AG
LTTKIA
G
KTLDLS
IPL
PQGARYQAWTR
K
E
P
V
GV
V
A
G
I
V
PWNFP
LM
I
GM
WK
VM
PALAAG
C
S
I
V
I
KPSE
T
TPLT
M
L
RV
A
E
L
AS
EAG
I
P
D
GV
F
NVV
T
G
S
G
AVC
G
AA
LT
S
HP
H
V
AK
I
S
F
TGS
TA
TGK
G
I
ART
A
A
D
-
R
L
T
RV
T
LELGGK
N
P
A
IV
LK
D
-
AD
-----
P
Q
W
V
IEGLMTGSFL
N
Q
GQVC
AASS
R
I
YIEAPLF
D
T
L
VSGFEQAVKSL
Q
V
G
PGMSPV
-
AQI
N
PL
V
S
R
AH
C
G
K
V
CSF
L
DD
A
QAQ
Q
-
AE
L
IR
G
S
--
NGPA
G
--
-
-
E
GY
YVA
PTL
VVNPDAKLR
L
TR
EE
V
FGPV
V
N
L
VRVADG
EEA
L
QL
AND
T
E
YGL
T
A
S
V
W
T
Q
N
L
SQ
A
L
E
Y
S
DR
L
Q
A
G
TV
WVN
SHTLIDANL
P
F
GG
M
K
Q
SG
T
G
RDF
G
PDW
L
DG
W
CET
K
S
V
C
V
fig|481805.3.peg.2436
Escherichia coli ATCC 8739 (5-497/499)
H
V
A
VLSQVQ
Q
F
LDR
Q
HG
L
Y
I
D
G
RPGPAQSE
---
KRLAIF
D
PAT
GQE
I
ASTAD
A
NEA
D
V
D
N
AV
M
S
A
WRA
F
VSRR
W
AGRL
P
AE
R
ERI
L
L
R
FA
D
L
V
E
QHSE
E
L
A
Q
LE
TL
E
Q
GK
SIAISRAF
E
V
GCTLNWMR
Y
T
AG
LTTKIA
G
KTLDLS
IPL
PQGARYQAWTR
K
E
P
V
GV
V
A
G
I
V
PWNFP
LM
I
GM
WK
VM
PALAAG
C
S
I
V
I
KPSE
T
TPLT
M
L
RV
A
E
L
AS
EAG
I
P
D
GV
F
NVV
T
G
S
G
AVC
G
AA
LT
S
HP
H
V
AK
I
S
F
TGS
TA
TGK
G
I
ART
A
A
D
-
R
L
T
RV
T
LELGGK
N
P
A
IV
LK
D
-
AD
-----
P
Q
W
V
IEGLMTGSFL
N
Q
GQVC
AASS
R
I
YIEAPLF
D
T
L
VSGFEQAVKSL
Q
V
G
PGMSPV
-
AQI
N
PL
V
S
R
AH
C
G
K
V
CSF
L
DD
A
QAQ
Q
-
AE
L
IR
G
S
--
NGPA
G
--
-
-
E
GY
YVA
PTL
VVNPDAKLR
L
TR
EE
V
FGPV
V
N
L
VRVADG
EEA
L
QL
AND
T
E
YGL
T
A
S
V
W
T
Q
N
L
SQ
A
L
E
Y
S
DR
L
Q
A
G
TV
WVN
SHTLIDANL
P
F
GG
M
K
Q
SG
T
G
RDF
G
PDW
L
DG
W
CET
K
S
V
C
V
fig|481805.6.peg.2425
Escherichia coli ATCC 8739 (5-497/499)
H
V
A
VLSQVQ
Q
F
LDR
Q
HG
L
Y
I
D
G
RPGPAQSE
---
KRLAIF
D
PAT
GQE
I
ASTAD
A
NEA
D
V
D
N
AV
M
S
A
WRA
F
VSRR
W
AGRL
P
AE
R
ERI
L
L
R
FA
D
L
V
E
QHSE
E
L
A
Q
LE
TL
E
Q
GK
SIAISRAF
E
V
GCTLNWMR
Y
T
AG
LTTKIA
G
KTLDLS
IPL
PQGARYQAWTR
K
E
P
V
GV
V
A
G
I
V
PWNFP
LM
I
GM
WK
VM
PALAAG
C
S
I
V
I
KPSE
T
TPLT
M
L
RV
A
E
L
AS
EAG
I
P
D
GV
F
NVV
T
G
S
G
AVC
G
AA
LT
S
HP
H
V
AK
I
S
F
TGS
TA
TGK
G
I
ART
A
A
D
-
R
L
T
RV
T
LELGGK
N
P
A
IV
LK
D
-
AD
-----
P
Q
W
V
IEGLMTGSFL
N
Q
GQVC
AASS
R
I
YIEAPLF
D
T
L
VSGFEQAVKSL
Q
V
G
PGMSPV
-
AQI
N
PL
V
S
R
AH
C
G
K
V
CSF
L
DD
A
QAQ
Q
-
AE
L
IR
G
S
--
NGPA
G
--
-
-
E
GY
YVA
PTL
VVNPDAKLR
L
TR
EE
V
FGPV
V
N
L
VRVADG
EEA
L
QL
AND
T
E
YGL
T
A
S
V
W
T
Q
N
L
SQ
A
L
E
Y
S
DR
L
Q
A
G
TV
WVN
SHTLIDANL
P
F
GG
M
K
Q
SG
T
G
RDF
G
PDW
L
DG
W
CET
K
S
V
C
V
fig|331112.3.peg.1381
Escherichia coli HS (5-497/499)
H
V
A
VLSQVQ
Q
F
LDR
Q
HG
L
Y
I
D
G
RPGPAQSE
---
KRLAIF
D
PAT
GQE
I
ASTAD
A
NEA
D
V
D
N
AV
M
S
A
WRA
F
VSRR
W
AGRL
P
AE
R
ERI
L
L
R
FA
D
L
V
E
QHSE
E
L
A
Q
LE
TL
E
Q
GK
SIAISRAF
E
V
GCTLNWMR
Y
T
AG
LTTKIA
G
KTLDLS
IPL
PQGARYQAWTR
K
E
P
V
GV
V
A
G
I
V
PWNFP
LM
I
GM
WK
VM
PALAAG
C
S
I
V
I
KPSE
T
TPLT
M
L
RV
A
E
L
AS
EAG
I
P
D
GV
F
NVV
T
G
S
G
AVC
G
AA
LT
S
HP
H
V
AK
I
S
F
TGS
TA
TGK
G
I
ART
A
A
D
-
R
L
T
RV
T
LELGGK
N
P
A
IV
LK
D
-
AD
-----
P
Q
W
V
IEGLMTGSFL
N
Q
GQVC
AASS
R
I
YIEAPLF
D
T
L
VSGFEQAVKSL
Q
V
G
PGMSPV
-
AQI
N
PL
V
S
R
AH
C
G
K
V
CSF
L
DD
A
QAQ
Q
-
AE
L
IR
G
S
--
NGPA
G
--
-
-
E
GY
YVA
PTL
VVNPDAKLR
L
TR
EE
V
FGPV
V
N
L
VRVADG
EEA
L
QL
AND
T
E
YGL
T
A
S
V
W
T
Q
N
L
SQ
A
L
E
Y
S
DR
L
Q
A
G
TV
WVN
SHTLIDANL
P
F
GG
M
K
Q
SG
T
G
RDF
G
PDW
L
DG
W
CET
K
S
V
C
V
fig|331112.6.peg.1438
Escherichia coli HS (5-497/499)
H
V
A
VLSQVQ
Q
F
LDR
Q
HG
L
Y
I
D
G
RPGPAQSE
---
KRLAIF
D
PAT
GQE
I
ASTAD
A
NEA
D
V
D
N
AV
M
S
A
WRA
F
VSRR
W
AGRL
P
AE
R
ERI
L
L
R
FA
D
L
V
E
QHSE
E
L
A
Q
LE
TL
E
Q
GK
SIAISRAF
E
V
GCTLNWMR
Y
T
AG
LTTKIA
G
KTLDLS
IPL
PQGARYQAWTR
K
E
P
V
GV
V
A
G
I
V
PWNFP
LM
I
GM
WK
VM
PALAAG
C
S
I
V
I
KPSE
T
TPLT
M
L
RV
A
E
L
AS
EAG
I
P
D
GV
F
NVV
T
G
S
G
AVC
G
AA
LT
S
HP
H
V
AK
I
S
F
TGS
TA
TGK
G
I
ART
A
A
D
-
R
L
T
RV
T
LELGGK
N
P
A
IV
LK
D
-
AD
-----
P
Q
W
V
IEGLMTGSFL
N
Q
GQVC
AASS
R
I
YIEAPLF
D
T
L
VSGFEQAVKSL
Q
V
G
PGMSPV
-
AQI
N
PL
V
S
R
AH
C
G
K
V
CSF
L
DD
A
QAQ
Q
-
AE
L
IR
G
S
--
NGPA
G
--
-
-
E
GY
YVA
PTL
VVNPDAKLR
L
TR
EE
V
FGPV
V
N
L
VRVADG
EEA
L
QL
AND
T
E
YGL
T
A
S
V
W
T
Q
N
L
SQ
A
L
E
Y
S
DR
L
Q
A
G
TV
WVN
SHTLIDANL
P
F
GG
M
K
Q
SG
T
G
RDF
G
PDW
L
DG
W
CET
K
S
V
C
V
fig|413997.3.peg.1430
Escherichia coli B str. REL606 (5-497/499)
H
V
A
VLSQVQ
Q
F
LDR
Q
HG
L
Y
I
D
G
RPGPAQSE
---
KRLAIF
D
PAT
GQE
I
ASTAD
A
NEA
D
V
D
N
AV
M
S
A
WRA
F
VSRR
W
AGRL
P
AE
R
ERI
L
L
R
FA
D
L
V
E
QHSE
E
L
A
Q
LE
PL
E
Q
GK
SIAISRAF
E
V
GCTLNWMR
Y
T
AG
LTTKIA
G
KTLDLS
IPL
PQGARYQAWTR
K
E
P
V
GV
V
A
G
I
V
PWNFP
LM
I
GM
WK
VM
PALAAG
C
S
I
V
I
KPSE
T
TPLT
M
L
RV
A
E
L
AS
EAG
I
P
D
GV
F
NVV
T
G
S
G
AVC
G
AA
LT
S
HP
H
V
AK
I
S
F
TGS
TA
TGK
G
I
ART
A
A
D
-
R
L
T
RV
T
LELGGK
N
P
A
IV
LK
D
-
AD
-----
P
Q
W
V
IEGLMTGSFL
N
Q
GQVC
AASS
R
I
YIEAPLF
D
T
L
VSGFEQAVKSL
Q
V
G
PGMSPV
-
AQI
N
PL
V
S
R
AH
C
G
K
V
CSF
L
DD
A
QAQ
Q
-
AE
L
IR
G
S
--
NGPA
G
--
-
-
E
GY
YVA
PTL
VVNPDAKLR
L
TR
EE
V
FGPV
V
N
L
VRVADG
EEA
L
QL
AND
T
E
YGL
T
A
S
V
W
T
Q
N
L
SQ
A
L
E
Y
S
DR
L
Q
A
G
TV
WVN
SHTLIDANL
P
F
GG
M
K
Q
SG
T
G
RDF
G
PDW
L
DG
W
CET
K
S
V
C
V
fig|511693.5.peg.1468
Escherichia coli BL21 (5-497/499)
H
V
A
VLSQVQ
Q
F
LDR
Q
HG
L
Y
I
D
G
RPGPAQSE
---
KRLAIF
D
PAT
GQE
I
ASTAD
A
NEA
D
V
D
N
AV
M
S
A
WRA
F
VSRR
W
AGRL
P
AE
R
ERI
L
L
R
FA
D
L
V
E
QHSE
E
L
A
Q
LE
PL
E
Q
GK
SIAISRAF
E
V
GCTLNWMR
Y
T
AG
LTTKIA
G
KTLDLS
IPL
PQGARYQAWTR
K
E
P
V
GV
V
A
G
I
V
PWNFP
LM
I
GM
WK
VM
PALAAG
C
S
I
V
I
KPSE
T
TPLT
M
L
RV
A
E
L
AS
EAG
I
P
D
GV
F
NVV
T
G
S
G
AVC
G
AA
LT
S
HP
H
V
AK
I
S
F
TGS
TA
TGK
G
I
ART
A
A
D
-
R
L
T
RV
T
LELGGK
N
P
A
IV
LK
D
-
AD
-----
P
Q
W
V
IEGLMTGSFL
N
Q
GQVC
AASS
R
I
YIEAPLF
D
T
L
VSGFEQAVKSL
Q
V
G
PGMSPV
-
AQI
N
PL
V
S
R
AH
C
G
K
V
CSF
L
DD
A
QAQ
Q
-
AE
L
IR
G
S
--
NGPA
G
--
-
-
E
GY
YVA
PTL
VVNPDAKLR
L
TR
EE
V
FGPV
V
N
L
VRVADG
EEA
L
QL
AND
T
E
YGL
T
A
S
V
W
T
Q
N
L
SQ
A
L
E
Y
S
DR
L
Q
A
G
TV
WVN
SHTLIDANL
P
F
GG
M
K
Q
SG
T
G
RDF
G
PDW
L
DG
W
CET
K
S
V
C
V
fig|469008.4.peg.2305
Escherichia coli BL21(DE3) (5-497/499)
H
V
A
VLSQVQ
Q
F
LDR
Q
HG
L
Y
I
D
G
RPGPAQSE
---
KRLAIF
D
PAT
GQE
I
ASTAD
A
NEA
D
V
D
N
AV
M
S
A
WRA
F
VSRR
W
AGRL
P
AE
R
ERI
L
L
R
FA
D
L
V
E
QHSE
E
L
A
Q
LE
PL
E
Q
GK
SIAISRAF
E
V
GCTLNWMR
Y
T
AG
LTTKIA
G
KTLDLS
IPL
PQGARYQAWTR
K
E
P
V
GV
V
A
G
I
V
PWNFP
LM
I
GM
WK
VM
PALAAG
C
S
I
V
I
KPSE
T
TPLT
M
L
RV
A
E
L
AS
EAG
I
P
D
GV
F
NVV
T
G
S
G
AVC
G
AA
LT
S
HP
H
V
AK
I
S
F
TGS
TA
TGK
G
I
ART
A
A
D
-
R
L
T
RV
T
LELGGK
N
P
A
IV
LK
D
-
AD
-----
P
Q
W
V
IEGLMTGSFL
N
Q
GQVC
AASS
R
I
YIEAPLF
D
T
L
VSGFEQAVKSL
Q
V
G
PGMSPV
-
AQI
N
PL
V
S
R
AH
C
G
K
V
CSF
L
DD
A
QAQ
Q
-
AE
L
IR
G
S
--
NGPA
G
--
-
-
E
GY
YVA
PTL
VVNPDAKLR
L
TR
EE
V
FGPV
V
N
L
VRVADG
EEA
L
QL
AND
T
E
YGL
T
A
S
V
W
T
Q
N
L
SQ
A
L
E
Y
S
DR
L
Q
A
G
TV
WVN
SHTLIDANL
P
F
GG
M
K
Q
SG
T
G
RDF
G
PDW
L
DG
W
CET
K
S
V
C
V
fig|749547.3.peg.240
Escherichia coli MS 187-1 (5-497/499)
H
V
A
VLSQVQ
Q
F
LDR
Q
HG
L
Y
I
D
G
RPGPAQSE
---
KRLAIF
D
PAT
GQE
I
ASTAD
A
NEA
D
V
D
N
AV
M
S
A
WRA
F
VSRR
W
AGRL
P
AE
R
ERI
L
L
R
FA
D
L
V
E
QHSE
E
L
A
Q
LE
PL
E
Q
GK
SIAISRAF
E
V
GCTLNWMR
Y
T
AG
LTTKIA
G
KTLDLS
IPL
PQGARYQAWTR
K
E
P
V
GV
V
A
G
I
V
PWNFP
LM
I
GM
WK
VM
PALAAG
C
S
I
V
I
KPSE
T
TPLT
M
L
RV
A
E
L
AS
EAG
I
P
D
GV
F
NVV
T
G
S
G
AVC
G
AA
LT
S
HP
H
V
AK
I
S
F
TGS
TA
TGK
G
I
ART
A
A
D
-
R
L
T
RV
T
LELGGK
N
P
A
IV
LK
D
-
AD
-----
P
Q
W
V
IEGLMTGSFL
N
Q
GQVC
AASS
R
I
YIEAPLF
D
T
L
VSGFEQAVKSL
Q
V
G
PGMSPV
-
AQI
N
PL
V
S
R
AH
C
G
K
V
CSF
L
DD
A
QAQ
Q
-
AE
L
IR
G
S
--
NGPA
G
--
-
-
E
GY
YVA
PTL
VVNPDAKLR
L
TR
EE
V
FGPV
V
N
L
VRVADG
EEA
L
QL
AND
T
E
YGL
T
A
S
V
W
T
Q
N
L
SQ
A
L
E
Y
S
DR
L
Q
A
G
TV
WVN
SHTLIDANL
P
F
GG
M
K
Q
SG
T
G
RDF
G
PDW
L
DG
W
CET
K
S
V
C
V
fig|637912.3.peg.2915
Escherichia coli OP50 (5-497/499)
H
V
A
VLSQVQ
Q
F
LDR
Q
HG
L
Y
I
D
G
RPGPAQSE
---
KRLAIF
D
PAT
GQE
I
ASTAD
A
NEA
D
V
D
N
AV
M
S
A
WRA
F
VSRR
W
AGRL
P
AE
R
ERI
L
L
R
FA
D
L
V
E
QHSE
E
L
A
Q
LE
PL
E
Q
GK
SIAISRAF
E
V
GCTLNWMR
Y
T
AG
LTTKIA
G
KTLDLS
IPL
PQGARYQAWTR
K
E
P
V
GV
V
A
G
I
V
PWNFP
LM
I
GM
WK
VM
PALAAG
C
S
I
V
I
KPSE
T
TPLT
M
L
RV
A
E
L
AS
EAG
I
P
D
GV
F
NVV
T
G
S
G
AVC
G
AA
LT
S
HP
H
V
AK
I
S
F
TGS
TA
TGK
G
I
ART
A
A
D
-
R
L
T
RV
T
LELGGK
N
P
A
IV
LK
D
-
AD
-----
P
Q
W
V
IEGLMTGSFL
N
Q
GQVC
AASS
R
I
YIEAPLF
D
T
L
VSGFEQAVKSL
Q
V
G
PGMSPV
-
AQI
N
PL
V
S
R
AH
C
G
K
V
CSF
L
DD
A
QAQ
Q
-
AE
L
IR
G
S
--
NGPA
G
--
-
-
E
GY
YVA
PTL
VVNPDAKLR
L
TR
EE
V
FGPV
V
N
L
VRVADG
EEA
L
QL
AND
T
E
YGL
T
A
S
V
W
T
Q
N
L
SQ
A
L
E
Y
S
DR
L
Q
A
G
TV
WVN
SHTLIDANL
P
F
GG
M
K
Q
SG
T
G
RDF
G
PDW
L
DG
W
CET
K
S
V
C
V
fig|362663.8.peg.382
Escherichia coli 536 (1-483/490)
M
S
RMA
E
QQ
L
Y
I
H
G
GYTSATSG
---
HTFETI
NPA
N
GNV
L
ATVQA
A
GRE
D
V
D
R
AV
K
S
A
QQG
Q
--KI
W
AAMT
A
ME
R
SRI
L
R
R
AV
D
I
L
R
ERND
E
L
A
K
LE
TL
D
T
GK
AYSETSTV
D
I
VTGADVLE
Y
Y
AG
LIPSLE
G
---SQI
---
PLRETSFVYTR
R
E
PLGV
V
A
G
I
G
A
WN
Y
P
IQ
I
AL
WK
SA
PALAAGN
A
M
I
F
KPSE
V
TPLTAL
KL
A
E
I
YS
EAG
L
P
D
GV
F
NV
L
P
G
V
G
AET
G
QY
LT
E
HP
G
I
AK
VS
F
TG
G
VA
S
GK
K
V
MAN
S
A
A
S
SL
K
E
V
T
M
ELGGKSP
L
IV
FD
D
-
AD
-----
L
E
L
A
ADIAMMANFF
S
S
GQVC
TNGT
RV
FVPAKCK
A
A
F
EQKILARVERI
R
A
D
DVFDPQ
-
TNF
GPL
V
S
F
P
H
R
D
N
V
LRY
I
AK
G
KEE
G
-
AR
V
LC
G
G
--
DVLK
G
DG
F
D
N
G
A
WVA
PT
V
FTDCSDDMT
I
VR
EE
I
FGPV
M
S
I
LIYESE
D
E
V
I
RR
AND
T
D
YGL
A
A
G
I
V
T
A
DL
NR
A
H
R
V
I
HQ
L
E
A
G
IC
W
I
N
TWGESPAEM
P
V
GG
Y
K
H
SG
I
G
REN
G
VMT
L
QS
Y
TQV
K
S
I
Q
V
E
M
fig|362663.9.peg.381
Escherichia coli 536 (1-483/490)
M
S
RMA
E
QQ
L
Y
I
H
G
GYTSATSG
---
HTFETI
NPA
N
GNV
L
ATVQA
A
GRE
D
V
D
R
AV
K
S
A
QQG
Q
--KI
W
AAMT
A
ME
R
SRI
L
R
R
AV
D
I
L
R
ERND
E
L
A
K
LE
TL
D
T
GK
AYSETSTV
D
I
VTGADVLE
Y
Y
AG
LIPSLE
G
---SQI
---
PLRETSFVYTR
R
E
PLGV
V
A
G
I
G
A
WN
Y
P
IQ
I
AL
WK
SA
PALAAGN
A
M
I
F
KPSE
V
TPLTAL
KL
A
E
I
YS
EAG
L
P
D
GV
F
NV
L
P
G
V
G
AET
G
QY
LT
E
HP
G
I
AK
VS
F
TG
G
VA
S
GK
K
V
MAN
S
A
A
S
SL
K
E
V
T
M
ELGGKSP
L
IV
FD
D
-
AD
-----
L
E
L
A
ADIAMMANFF
S
S
GQVC
TNGT
RV
FVPAKCK
A
A
F
EQKILARVERI
R
A
D
DVFDPQ
-
TNF
GPL
V
S
F
P
H
R
D
N
V
LRY
I
AK
G
KEE
G
-
AR
V
LC
G
G
--
DVLK
G
DG
F
D
N
G
A
WVA
PT
V
FTDCSDDMT
I
VR
EE
I
FGPV
M
S
I
LIYESE
D
E
V
I
RR
AND
T
D
YGL
A
A
G
I
V
T
A
DL
NR
A
H
R
V
I
HQ
L
E
A
G
IC
W
I
N
TWGESPAEM
P
V
GG
Y
K
H
SG
I
G
REN
G
VMT
L
QS
Y
TQV
K
S
I
Q
V
E
M
fig|340197.3.peg.3689
Escherichia coli F11 (1-483/490)
M
S
RMA
E
QQ
L
Y
I
H
G
GYTSATSG
---
HTFETI
NPA
N
GNV
L
ATVQA
A
GRE
D
V
D
R
AV
K
S
A
QQG
Q
--KI
W
AAMT
A
ME
R
SRI
L
R
R
AV
D
I
L
R
ERND
E
L
A
K
LE
TL
D
T
GK
AYSETSTV
D
I
VTGADVLE
Y
Y
AG
LIPSLE
G
---SQI
---
PLRETSFVYTR
R
E
PLGV
V
A
G
I
G
A
WN
Y
P
IQ
I
AL
WK
SA
PALAAGN
A
M
I
F
KPSE
V
TPLTAL
KL
A
E
I
YS
EAG
L
P
D
GV
F
NV
L
P
G
V
G
AET
G
QY
LT
E
HP
G
I
AK
VS
F
TG
G
VA
S
GK
K
V
MAN
S
A
A
S
SL
K
E
V
T
M
ELGGKSP
L
IV
FD
D
-
AD
-----
L
E
L
A
ADIAMMANFF
S
S
GQVC
TNGT
RV
FVPAKCK
A
A
F
EQKILARVERI
R
A
D
DVFDPQ
-
TNF
GPL
V
S
F
P
H
R
D
N
V
LRY
I
AK
G
KEE
G
-
AR
V
LC
G
G
--
DVLK
G
DG
F
D
N
G
A
WVA
PT
V
FTDCSDDMT
I
VR
EE
I
FGPV
M
S
I
LIYESE
D
E
V
I
RR
AND
T
D
YGL
A
A
G
I
V
T
A
DL
NR
A
H
R
V
I
HQ
L
E
A
G
IC
W
I
N
TWGESPAEM
P
V
GG
Y
K
H
SG
I
G
REN
G
VMT
L
QS
Y
TQV
K
S
I
Q
V
E
M
fig|340197.5.peg.3856
Escherichia coli F11 (1-483/490)
M
S
RMA
E
QQ
L
Y
I
H
G
GYTSATSG
---
HTFETI
NPA
N
GNV
L
ATVQA
A
GRE
D
V
D
R
AV
K
S
A
QQG
Q
--KI
W
AAMT
A
ME
R
SRI
L
R
R
AV
D
I
L
R
ERND
E
L
A
K
LE
TL
D
T
GK
AYSETSTV
D
I
VTGADVLE
Y
Y
AG
LIPSLE
G
---SQI
---
PLRETSFVYTR
R
E
PLGV
V
A
G
I
G
A
WN
Y
P
IQ
I
AL
WK
SA
PALAAGN
A
M
I
F
KPSE
V
TPLTAL
KL
A
E
I
YS
EAG
L
P
D
GV
F
NV
L
P
G
V
G
AET
G
QY
LT
E
HP
G
I
AK
VS
F
TG
G
VA
S
GK
K
V
MAN
S
A
A
S
SL
K
E
V
T
M
ELGGKSP
L
IV
FD
D
-
AD
-----
L
E
L
A
ADIAMMANFF
S
S
GQVC
TNGT
RV
FVPAKCK
A
A
F
EQKILARVERI
R
A
D
DVFDPQ
-
TNF
GPL
V
S
F
P
H
R
D
N
V
LRY
I
AK
G
KEE
G
-
AR
V
LC
G
G
--
DVLK
G
DG
F
D
N
G
A
WVA
PT
V
FTDCSDDMT
I
VR
EE
I
FGPV
M
S
I
LIYESE
D
E
V
I
RR
AND
T
D
YGL
A
A
G
I
V
T
A
DL
NR
A
H
R
V
I
HQ
L
E
A
G
IC
W
I
N
TWGESPAEM
P
V
GG
Y
K
H
SG
I
G
REN
G
VMT
L
QS
Y
TQV
K
S
I
Q
V
E
M
fig|749550.3.peg.916
Escherichia coli MS 200-1 (1-483/490)
M
S
RMA
E
QQ
L
Y
I
H
G
GYTSATSG
---
HTFETI
NPA
N
GNV
L
ATVQA
A
GRE
D
V
D
R
AV
K
S
A
QQG
Q
--KI
W
AAMT
A
ME
R
SRI
L
R
R
AV
D
I
L
R
ERND
E
L
A
K
LE
TL
D
T
GK
AYSETSTV
D
I
VTGADVLE
Y
Y
AG
LIPSLE
G
---SQI
---
PLRETSFVYTR
R
E
PLGV
V
A
G
I
G
A
WN
Y
P
IQ
I
AL
WK
SA
PALAAGN
A
M
I
F
KPSE
V
TPLTAL
KL
A
E
I
YS
EAG
L
P
D
GV
F
NV
L
P
G
V
G
AET
G
QY
LT
E
HP
G
I
AK
VS
F
TG
G
VA
S
GK
K
V
MAN
S
A
A
S
SL
K
E
V
T
M
ELGGKSP
L
IV
FD
D
-
AD
-----
L
E
L
A
ADIAMMANFF
S
S
GQVC
TNGT
RV
FVPAKCK
A
A
F
EQKILARVERI
R
A
D
DVFDPQ
-
TNF
GPL
V
S
F
P
H
R
D
N
V
LRY
I
AK
G
KEE
G
-
AR
V
LC
G
G
--
DVLK
G
DG
F
D
N
G
A
WVA
PT
V
FTDCSDDMT
I
VR
EE
I
FGPV
M
S
I
LIYESE
D
E
V
I
RR
AND
T
D
YGL
A
A
G
I
V
T
A
DL
NR
A
H
R
V
I
HQ
L
E
A
G
IC
W
I
N
TWGESPAEM
P
V
GG
Y
K
H
SG
I
G
REN
G
VMT
L
QS
Y
TQV
K
S
I
Q
V
E
M
fig|6666666.5357.peg.3726
Escherichia coli TY-2482 (2-484/491)
M
S
RMA
E
QQ
L
Y
I
H
G
GYTSATSG
---
RTFETI
NPA
N
GNV
L
ATVQA
A
GRE
D
V
D
R
AV
K
S
A
QQG
Q
--KI
W
AAMT
A
ME
R
SRI
L
R
R
AV
D
I
L
R
ERND
E
L
A
K
LE
TL
D
T
GK
AYSETSTV
D
I
VTGADVLE
Y
Y
AG
LIPALE
G
---SQI
---
PLRETSFVYTR
R
E
PLGV
V
A
G
I
G
A
WN
Y
P
IQ
I
AC
WK
SA
PALAAGN
A
M
I
F
KPSE
V
TPLTAL
KL
A
E
I
YS
EAG
L
P
D
GV
F
NV
L
P
G
V
G
AET
G
QY
LT
E
HP
G
I
AK
VS
F
TG
G
VA
S
GK
K
V
MAN
S
A
A
S
SL
K
E
V
T
M
ELGGKSP
L
IV
FD
D
-
AD
-----
L
D
L
A
ADIAMMANFF
S
S
GQVC
TNGT
RV
FVPAKCK
A
A
F
EQKILARVERI
R
A
G
DVFDPQ
-
TNF
GPL
V
S
F
P
H
R
D
N
V
LRY
I
AK
G
KEE
G
-
AR
V
LC
G
G
--
DVLK
G
DG
F
D
N
G
A
WVA
PT
V
FTDCSDDMT
I
VR
EE
I
FGPV
M
S
L
LTYESE
D
E
V
I
RR
AND
T
D
YGL
A
A
G
I
V
T
A
DL
NR
A
H
R
V
I
HQ
L
E
A
G
IC
W
I
N
TWGESPAEM
P
V
GG
Y
K
H
SG
I
G
REN
G
VMT
L
QS
Y
TQV
K
S
I
Q
V
E
M
fig|701177.3.peg.4348
Escherichia coli O55:H7 str. CB9615 (19-503/512)
L
K
LKN
R
YD
N
F
I
G
G
EWVAPADG
---
EYYQNL
T
P
V
T
GQL
L
CEVAS
S
GKR
D
I
D
L
A
L
D
AA
HKV
K
--DK
W
AHTS
V
QD
R
AAI
L
F
K
IA
D
R
M
E
QNLE
L
L
A
T
A
E
TW
D
N
GK
PIRETSAA
DV
PLAIDHFR
Y
F
A
S
CIRAQE
G
GISEVD
---
---SETVAYHF
H
E
PLGV
V
G
Q
I
I
PWNFP
LL
M
AS
WK
MA
PALAAGN
C
VV
L
KP
A
R
L
TPL
S
V
L
LL
M
E
I
VG
D
L
-
L
P
P
GV
V
NVV
N
G
A
G
GEI
G
EY
L
A
T
SK
R
I
AK
V
A
F
TGS
TE
V
G
Q
Q
I
MQY
A
-
T
Q
NI
IP
V
T
LELGGKSP
N
I
F
FA
D
VM
D
EEDAF
F
D
K
A
LEGFALFAF-
N
Q
G
E
VC
TCPS
R
A
LVQESIY
E
R
F
MERAIRRVESI
R
S
G
NPLDSV
-
TQM
G
AQ
V
S
H
GQ
L
E
T
I
LNY
I
DI
G
KKE
G
-
AD
V
LT
G
G
RR
KLLE
G
-
E
L
K
D
GY
YLE
PT
I
LFG-QNNMR
V
FQ
EE
I
FGPVL
A
V
TTFKTM
EEA
L
EL
AND
T
QYGL
G
A
G
V
W
S
R
N
G
NL
A
Y
K
M
G
RG
IQ
A
G
RV
W
T
N
CYHAYPAHA
A
F
GG
Y
K
Q
SG
I
G
RET
H
KMM
L
EH
Y
QQT
K
C
L
L
VS
fig|525281.3.peg.2581
Escherichia coli 83972 (1-483/490)
M
S
RMA
E
QQ
L
Y
I
H
G
GYTSATSG
---
RTFETI
NPA
N
GNV
L
ATVQA
A
GRE
D
V
D
R
AV
K
S
A
QQG
Q
--KI
W
AAMT
A
ME
R
SRI
L
R
R
AV
D
I
L
R
ERND
E
L
A
K
LE
TL
D
T
GK
AYSETSTV
D
I
VTGADVLE
Y
Y
AG
LIPALE
G
---SQI
---
PLRETSFVYTR
R
E
PLGV
V
A
G
I
G
A
WN
Y
P
IQ
I
AL
WK
SA
PALAAGN
A
M
I
F
KPSE
V
TPLTAL
KL
A
E
I
YS
EAG
L
P
D
GV
F
NV
L
P
G
V
G
AET
G
QY
LT
D
HP
G
I
AK
VS
F
TG
G
VA
S
GK
K
V
MAN
S
A
A
S
SL
K
E
V
T
M
ELGGKSP
L
IV
FD
D
-
AD
-----
L
D
L
A
ADIAMMANFF
S
S
GQVC
TNGT
RV
FVPTKCK
A
A
F
EQKVLARVERI
R
A
G
DVFDPQ
-
TNF
GPL
V
S
F
P
H
R
D
N
V
LRY
I
AK
G
KEE
G
-
AR
V
LC
G
G
--
NVLK
G
D
S
F
D
N
G
A
WVA
PT
V
FTDCSDDMT
I
VR
EE
I
FGPV
M
S
I
LTYESE
D
E
V
I
RR
AND
T
D
YGL
A
A
G
I
V
T
A
DL
NR
A
H
R
V
I
HQ
L
E
A
G
IC
W
I
N
TWGESPAEI
P
V
GG
Y
K
H
SG
I
G
REN
G
VMT
L
QS
Y
TQV
K
S
I
Q
V
E
M
fig|655817.3.peg.437
Escherichia coli ABU 83972 (1-483/490)
M
S
RMA
E
QQ
L
Y
I
H
G
GYTSATSG
---
RTFETI
NPA
N
GNV
L
ATVQA
A
GRE
D
V
D
R
AV
K
S
A
QQG
Q
--KI
W
AAMT
A
ME
R
SRI
L
R
R
AV
D
I
L
R
ERND
E
L
A
K
LE
TL
D
T
GK
AYSETSTV
D
I
VTGADVLE
Y
Y
AG
LIPALE
G
---SQI
---
PLRETSFVYTR
R
E
PLGV
V
A
G
I
G
A
WN
Y
P
IQ
I
AL
WK
SA
PALAAGN
A
M
I
F
KPSE
V
TPLTAL
KL
A
E
I
YS
EAG
L
P
D
GV
F
NV
L
P
G
V
G
AET
G
QY
LT
D
HP
G
I
AK
VS
F
TG
G
VA
S
GK
K
V
MAN
S
A
A
S
SL
K
E
V
T
M
ELGGKSP
L
IV
FD
D
-
AD
-----
L
D
L
A
ADIAMMANFF
S
S
GQVC
TNGT
RV
FVPTKCK
A
A
F
EQKVLARVERI
R
A
G
DVFDPQ
-
TNF
GPL
V
S
F
P
H
R
D
N
V
LRY
I
AK
G
KEE
G
-
AR
V
LC
G
G
--
NVLK
G
D
S
F
D
N
G
A
WVA
PT
V
FTDCSDDMT
I
VR
EE
I
FGPV
M
S
I
LTYESE
D
E
V
I
RR
AND
T
D
YGL
A
A
G
I
V
T
A
DL
NR
A
H
R
V
I
HQ
L
E
A
G
IC
W
I
N
TWGESPAEI
P
V
GG
Y
K
H
SG
I
G
REN
G
VMT
L
QS
Y
TQV
K
S
I
Q
V
E
M
fig|199310.4.peg.405
Escherichia coli CFT073 (1-483/490)
M
S
RMA
E
QQ
L
Y
I
H
G
GYTSATSG
---
RTFETI
NPA
N
GNV
L
ATVQA
A
GRE
D
V
D
R
AV
K
S
A
QQG
Q
--KI
W
AAMT
A
ME
R
SRI
L
R
R
AV
D
I
L
R
ERND
E
L
A
K
LE
TL
D
T
GK
AYSETSTV
D
I
VTGADVLE
Y
Y
AG
LIPALE
G
---SQI
---
PLRETSFVYTR
R
E
PLGV
V
A
G
I
G
A
WN
Y
P
IQ
I
AL
WK
SA
PALAAGN
A
M
I
F
KPSE
V
TPLTAL
KL
A
E
I
YS
EAG
L
P
D
GV
F
NV
L
P
G
V
G
AET
G
QY
LT
D
HP
G
I
AK
VS
F
TG
G
VA
S
GK
K
V
MAN
S
A
A
S
SL
K
E
V
T
M
ELGGKSP
L
IV
FD
D
-
AD
-----
L
D
L
A
ADIAMMANFF
S
S
GQVC
TNGT
RV
FVPTKCK
A
A
F
EQKVLARVERI
R
A
G
DVFDPQ
-
TNF
GPL
V
S
F
P
H
R
D
N
V
LRY
I
AK
G
KEE
G
-
AR
V
LC
G
G
--
NVLK
G
D
S
F
D
N
G
A
WVA
PT
V
FTDCSDDMT
I
VR
EE
I
FGPV
M
S
I
LTYESE
D
E
V
I
RR
AND
T
D
YGL
A
A
G
I
V
T
A
DL
NR
A
H
R
V
I
HQ
L
E
A
G
IC
W
I
N
TWGESPAEI
P
V
GG
Y
K
H
SG
I
G
REN
G
VMT
L
QS
Y
TQV
K
S
I
Q
V
E
M
fig|749528.3.peg.1379
Escherichia coli MS 45-1 (1-483/490)
M
S
RMA
E
QQ
L
Y
I
H
G
GYTSATSG
---
RTFETI
NPA
N
GNV
L
ATVQA
A
GRE
D
V
D
R
AV
K
S
A
QQG
Q
--KI
W
AAMT
A
ME
R
SRI
L
R
R
AV
D
I
L
R
ERND
E
L
A
K
LE
TL
D
T
GK
AYSETSTV
D
I
VTGADVLE
Y
Y
AG
LIPALE
G
---SQI
---
PLRETSFVYTR
R
E
PLGV
V
A
G
I
G
A
WN
Y
P
IQ
I
AL
WK
SA
PALAAGN
A
M
I
F
KPSE
V
TPLTAL
KL
A
E
I
YS
EAG
L
P
D
GV
F
NV
L
P
G
V
G
AET
G
QY
LT
D
HP
G
I
AK
VS
F
TG
G
VA
S
GK
K
V
MAN
S
A
A
S
SL
K
E
V
T
M
ELGGKSP
L
IV
FD
D
-
AD
-----
L
D
L
A
ADIAMMANFF
S
S
GQVC
TNGT
RV
FVPTKCK
A
A
F
EQKVLARVERI
R
A
G
DVFDPQ
-
TNF
GPL
V
S
F
P
H
R
D
N
V
LRY
I
AK
G
KEE
G
-
AR
V
LC
G
G
--
NVLK
G
D
S
F
D
N
G
A
WVA
PT
V
FTDCSDDMT
I
VR
EE
I
FGPV
M
S
I
LTYESE
D
E
V
I
RR
AND
T
D
YGL
A
A
G
I
V
T
A
DL
NR
A
H
R
V
I
HQ
L
E
A
G
IC
W
I
N
TWGESPAEI
P
V
GG
Y
K
H
SG
I
G
REN
G
VMT
L
QS
Y
TQV
K
S
I
Q
V
E
M
fig|199310.1.peg.413
Escherichia coli CFT073 (2-484/491)
M
S
RMA
E
QQ
L
Y
I
H
G
GYTSATSG
---
RTFETI
NPA
N
GNV
L
ATVQA
A
GRE
D
V
D
R
AV
K
S
A
QQG
Q
--KI
W
AAMT
A
ME
R
SRI
L
R
R
AV
D
I
L
R
ERND
E
L
A
K
LE
TL
D
T
GK
AYSETSTV
D
I
VTGADVLE
Y
Y
AG
LIPALE
G
---SQI
---
PLRETSFVYTR
R
E
PLGV
V
A
G
I
G
A
WN
Y
P
IQ
I
AL
WK
SA
PALAAGN
A
M
I
F
KPSE
V
TPLTAL
KL
A
E
I
YS
EAG
L
P
D
GV
F
NV
L
P
G
V
G
AET
G
QY
LT
D
HP
G
I
AK
VS
F
TG
G
VA
S
GK
K
V
MAN
S
A
A
S
SL
K
E
V
T
M
ELGGKSP
L
IV
FD
D
-
AD
-----
L
D
L
A
ADIAMMANFF
S
S
GQVC
TNGT
RV
FVPTKCK
A
A
F
EQKVLARVERI
R
A
G
DVFDPQ
-
TNF
GPL
V
S
F
P
H
R
D
N
V
LRY
I
AK
G
KEE
G
-
AR
V
LC
G
G
--
NVLK
G
D
S
F
D
N
G
A
WVA
PT
V
FTDCSDDMT
I
VR
EE
I
FGPV
M
S
I
LTYESE
D
E
V
I
RR
AND
T
D
YGL
A
A
G
I
V
T
A
DL
NR
A
H
R
V
I
HQ
L
E
A
G
IC
W
I
N
TWGESPAEI
P
V
GG
Y
K
H
SG
I
G
REN
G
VMT
L
QS
Y
TQV
K
S
I
Q
V
E
M
fig|562.371.peg.3213
Escherichia coli 1044A (19-503/512)
L
K
LKN
R
YD
N
F
I
G
G
EWVAPADG
---
EYYQNL
T
P
V
T
GQL
L
CEVAS
S
GKR
D
I
D
L
A
L
D
AA
HKV
K
--DK
W
AHTS
V
QD
R
AAI
L
F
K
IA
D
R
M
E
QNLE
L
L
A
T
A
E
AW
D
N
GK
PIRETSAA
DV
PLAIDHFR
Y
F
A
S
CIRAQE
G
GISEVD
---
---SETVAYHF
H
E
PLGV
V
G
Q
I
I
PWNFP
LL
M
AS
WK
MA
PALAAGN
C
VV
L
KP
A
R
L
TPL
S
V
L
LL
M
E
I
VG
D
L
-
L
P
P
GV
V
NVV
N
G
A
G
GEI
G
EY
L
A
T
SK
R
I
AK
V
A
F
TGS
TE
V
G
Q
Q
I
MQY
A
-
T
Q
NI
IP
V
T
LELGGKSP
N
I
F
FA
D
VM
D
EEDAF
F
D
K
A
LEGFALFAF-
N
Q
G
E
VC
TCPS
R
A
LVQESIY
E
R
F
MERAIRRVESI
R
S
G
NPLDSV
-
TQM
G
AQ
V
S
H
GQ
L
E
T
I
LNY
I
DI
G
KKE
G
-
AD
V
LT
G
G
RR
KLLE
G
-
E
L
K
D
GY
YLE
PT
I
LFG-QNNMR
V
FQ
EE
I
FGPVL
A
V
TTFKTM
EEA
L
EL
AND
T
QYGL
G
A
G
V
W
S
R
N
G
NL
A
Y
K
M
G
RG
IQ
A
G
RV
W
T
N
CYHAYPAHA
A
F
GG
Y
K
Q
SG
I
G
RET
H
KMM
L
EH
Y
QQT
K
C
L
L
VS
fig|562.373.peg.1628
Escherichia coli 1125A (19-503/512)
L
K
LKN
R
YD
N
F
I
G
G
EWVAPADG
---
EYYQNL
T
P
V
T
GQL
L
CEVAS
S
GKR
D
I
D
L
A
L
D
AA
HKV
K
--DK
W
AHTS
V
QD
R
AAI
L
F
K
IA
D
R
M
E
QNLE
L
L
A
T
A
E
AW
D
N
GK
PIRETSAA
DV
PLAIDHFR
Y
F
A
S
CIRAQE
G
GISEVD
---
---SETVAYHF
H
E
PLGV
V
G
Q
I
I
PWNFP
LL
M
AS
WK
MA
PALAAGN
C
VV
L
KP
A
R
L
TPL
S
V
L
LL
M
E
I
VG
D
L
-
L
P
P
GV
V
NVV
N
G
A
G
GEI
G
EY
L
A
T
SK
R
I
AK
V
A
F
TGS
TE
V
G
Q
Q
I
MQY
A
-
T
Q
NI
IP
V
T
LELGGKSP
N
I
F
FA
D
VM
D
EEDAF
F
D
K
A
LEGFALFAF-
N
Q
G
E
VC
TCPS
R
A
LVQESIY
E
R
F
MERAIRRVESI
R
S
G
NPLDSV
-
TQM
G
AQ
V
S
H
GQ
L
E
T
I
LNY
I
DI
G
KKE
G
-
AD
V
LT
G
G
RR
KLLE
G
-
E
L
K
D
GY
YLE
PT
I
LFG-QNNMR
V
FQ
EE
I
FGPVL
A
V
TTFKTM
EEA
L
EL
AND
T
QYGL
G
A
G
V
W
S
R
N
G
NL
A
Y
K
M
G
RG
IQ
A
G
RV
W
T
N
CYHAYPAHA
A
F
GG
Y
K
Q
SG
I
G
RET
H
KMM
L
EH
Y
QQT
K
C
L
L
VS
fig|562.372.peg.4095
Escherichia coli 1212A (19-503/512)
L
K
LKN
R
YD
N
F
I
G
G
EWVAPADG
---
EYYQNL
T
P
V
T
GQL
L
CEVAS
S
GKR
D
I
D
L
A
L
D
AA
HKV
K
--DK
W
AHTS
V
QD
R
AAI
L
F
K
IA
D
R
M
E
QNLE
L
L
A
T
A
E
AW
D
N
GK
PIRETSAA
DV
PLAIDHFR
Y
F
A
S
CIRAQE
G
GISEVD
---
---SETVAYHF
H
E
PLGV
V
G
Q
I
I
PWNFP
LL
M
AS
WK
MA
PALAAGN
C
VV
L
KP
A
R
L
TPL
S
V
L
LL
M
E
I
VG
D
L
-
L
P
P
GV
V
NVV
N
G
A
G
GEI
G
EY
L
A
T
SK
R
I
AK
V
A
F
TGS
TE
V
G
Q
Q
I
MQY
A
-
T
Q
NI
IP
V
T
LELGGKSP
N
I
F
FA
D
VM
D
EEDAF
F
D
K
A
LEGFALFAF-
N
Q
G
E
VC
TCPS
R
A
LVQESIY
E
R
F
MERAIRRVESI
R
S
G
NPLDSV
-
TQM
G
AQ
V
S
H
GQ
L
E
T
I
LNY
I
DI
G
KKE
G
-
AD
V
LT
G
G
RR
KLLE
G
-
E
L
K
D
GY
YLE
PT
I
LFG-QNNMR
V
FQ
EE
I
FGPVL
A
V
TTFKTM
EEA
L
EL
AND
T
QYGL
G
A
G
V
W
S
R
N
G
NL
A
Y
K
M
G
RG
IQ
A
G
RV
W
T
N
CYHAYPAHA
A
F
GG
Y
K
Q
SG
I
G
RET
H
KMM
L
EH
Y
QQT
K
C
L
L
VS
fig|562.374.peg.5219
Escherichia coli 536A (19-503/512)
L
K
LKN
R
YD
N
F
I
G
G
EWVAPADG
---
EYYQNL
T
P
V
T
GQL
L
CEVAS
S
GKR
D
I
D
L
A
L
D
AA
HKV
K
--DK
W
AHTS
V
QD
R
AAI
L
F
K
IA
D
R
M
E
QNLE
L
L
A
T
A
E
AW
D
N
GK
PIRETSAA
DV
PLAIDHFR
Y
F
A
S
CIRAQE
G
GISEVD
---
---SETVAYHF
H
E
PLGV
V
G
Q
I
I
PWNFP
LL
M
AS
WK
MA
PALAAGN
C
VV
L
KP
A
R
L
TPL
S
V
L
LL
M
E
I
VG
D
L
-
L
P
P
GV
V
NVV
N
G
A
G
GEI
G
EY
L
A
T
SK
R
I
AK
V
A
F
TGS
TE
V
G
Q
Q
I
MQY
A
-
T
Q
NI
IP
V
T
LELGGKSP
N
I
F
FA
D
VM
D
EEDAF
F
D
K
A
LEGFALFAF-
N
Q
G
E
VC
TCPS
R
A
LVQESIY
E
R
F
MERAIRRVESI
R
S
G
NPLDSV
-
TQM
G
AQ
V
S
H
GQ
L
E
T
I
LNY
I
DI
G
KKE
G
-
AD
V
LT
G
G
RR
KLLE
G
-
E
L
K
D
GY
YLE
PT
I
LFG-QNNMR
V
FQ
EE
I
FGPVL
A
V
TTFKTM
EEA
L
EL
AND
T
QYGL
G
A
G
V
W
S
R
N
G
NL
A
Y
K
M
G
RG
IQ
A
G
RV
W
T
N
CYHAYPAHA
A
F
GG
Y
K
Q
SG
I
G
RET
H
KMM
L
EH
Y
QQT
K
C
L
L
VS
fig|83334.1.peg.4435
Escherichia coli O157:H7 (19-503/512)
L
K
LKN
R
YD
N
F
I
G
G
EWVAPADG
---
EYYQNL
T
P
V
T
GQL
L
CEVAS
S
GKR
D
I
D
L
A
L
D
AA
HKV
K
--DK
W
AHTS
V
QD
R
AAI
L
F
K
IA
D
R
M
E
QNLE
L
L
A
T
A
E
AW
D
N
GK
PIRETSAA
DV
PLAIDHFR
Y
F
A
S
CIRAQE
G
GISEVD
---
---SETVAYHF
H
E
PLGV
V
G
Q
I
I
PWNFP
LL
M
AS
WK
MA
PALAAGN
C
VV
L
KP
A
R
L
TPL
S
V
L
LL
M
E
I
VG
D
L
-
L
P
P
GV
V
NVV
N
G
A
G
GEI
G
EY
L
A
T
SK
R
I
AK
V
A
F
TGS
TE
V
G
Q
Q
I
MQY
A
-
T
Q
NI
IP
V
T
LELGGKSP
N
I
F
FA
D
VM
D
EEDAF
F
D
K
A
LEGFALFAF-
N
Q
G
E
VC
TCPS
R
A
LVQESIY
E
R
F
MERAIRRVESI
R
S
G
NPLDSV
-
TQM
G
AQ
V
S
H
GQ
L
E
T
I
LNY
I
DI
G
KKE
G
-
AD
V
LT
G
G
RR
KLLE
G
-
E
L
K
D
GY
YLE
PT
I
LFG-QNNMR
V
FQ
EE
I
FGPVL
A
V
TTFKTM
EEA
L
EL
AND
T
QYGL
G
A
G
V
W
S
R
N
G
NL
A
Y
K
M
G
RG
IQ
A
G
RV
W
T
N
CYHAYPAHA
A
F
GG
Y
K
Q
SG
I
G
RET
H
KMM
L
EH
Y
QQT
K
C
L
L
VS
fig|155864.1.peg.4475
Escherichia coli O157:H7 EDL933 (49-533/542)
L
K
LKN
R
YD
N
F
I
G
G
EWVAPADG
---
EYYQNL
T
P
V
T
GQL
L
CEVAS
S
GKR
D
I
D
L
A
L
D
AA
HKV
K
--DK
W
AHTS
V
QD
R
AAI
L
F
K
IA
D
R
M
E
QNLE
L
L
A
T
A
E
AW
D
N
GK
PIRETSAA
DV
PLAIDHFR
Y
F
A
S
CIRAQE
G
GISEVD
---
---SETVAYHF
H
E
PLGV
V
G
Q
I
I
PWNFP
LL
M
AS
WK
MA
PALAAGN
C
VV
L
KP
A
R
L
TPL
S
V
L
LL
M
E
I
VG
D
L
-
L
P
P
GV
V
NVV
N
G
A
G
GEI
G
EY
L
A
T
SK
R
I
AK
V
A
F
TGS
TE
V
G
Q
Q
I
MQY
A
-
T
Q
NI
IP
V
T
LELGGKSP
N
I
F
FA
D
VM
D
EEDAF
F
D
K
A
LEGFALFAF-
N
Q
G
E
VC
TCPS
R
A
LVQESIY
E
R
F
MERAIRRVESI
R
S
G
NPLDSV
-
TQM
G
AQ
V
S
H
GQ
L
E
T
I
LNY
I
DI
G
KKE
G
-
AD
V
LT
G
G
RR
KLLE
G
-
E
L
K
D
GY
YLE
PT
I
LFG-QNNMR
V
FQ
EE
I
FGPVL
A
V
TTFKTM
EEA
L
EL
AND
T
QYGL
G
A
G
V
W
S
R
N
G
NL
A
Y
K
M
G
RG
IQ
A
G
RV
W
T
N
CYHAYPAHA
A
F
GG
Y
K
Q
SG
I
G
RET
H
KMM
L
EH
Y
QQT
K
C
L
L
VS
fig|155864.8.peg.4433
Escherichia coli O157:H7 EDL933 (19-503/512)
L
K
LKN
R
YD
N
F
I
G
G
EWVAPADG
---
EYYQNL
T
P
V
T
GQL
L
CEVAS
S
GKR
D
I
D
L
A
L
D
AA
HKV
K
--DK
W
AHTS
V
QD
R
AAI
L
F
K
IA
D
R
M
E
QNLE
L
L
A
T
A
E
AW
D
N
GK
PIRETSAA
DV
PLAIDHFR
Y
F
A
S
CIRAQE
G
GISEVD
---
---SETVAYHF
H
E
PLGV
V
G
Q
I
I
PWNFP
LL
M
AS
WK
MA
PALAAGN
C
VV
L
KP
A
R
L
TPL
S
V
L
LL
M
E
I
VG
D
L
-
L
P
P
GV
V
NVV
N
G
A
G
GEI
G
EY
L
A
T
SK
R
I
AK
V
A
F
TGS
TE
V
G
Q
Q
I
MQY
A
-
T
Q
NI
IP
V
T
LELGGKSP
N
I
F
FA
D
VM
D
EEDAF
F
D
K
A
LEGFALFAF-
N
Q
G
E
VC
TCPS
R
A
LVQESIY
E
R
F
MERAIRRVESI
R
S
G
NPLDSV
-
TQM
G
AQ
V
S
H
GQ
L
E
T
I
LNY
I
DI
G
KKE
G
-
AD
V
LT
G
G
RR
KLLE
G
-
E
L
K
D
GY
YLE
PT
I
LFG-QNNMR
V
FQ
EE
I
FGPVL
A
V
TTFKTM
EEA
L
EL
AND
T
QYGL
G
A
G
V
W
S
R
N
G
NL
A
Y
K
M
G
RG
IQ
A
G
RV
W
T
N
CYHAYPAHA
A
F
GG
Y
K
Q
SG
I
G
RET
H
KMM
L
EH
Y
QQT
K
C
L
L
VS
fig|444454.5.peg.3561
Escherichia coli O157:H7 str. EC4024 (19-503/512)
L
K
LKN
R
YD
N
F
I
G
G
EWVAPADG
---
EYYQNL
T
P
V
T
GQL
L
CEVAS
S
GKR
D
I
D
L
A
L
D
AA
HKV
K
--DK
W
AHTS
V
QD
R
AAI
L
F
K
IA
D
R
M
E
QNLE
L
L
A
T
A
E
AW
D
N
GK
PIRETSAA
DV
PLAIDHFR
Y
F
A
S
CIRAQE
G
GISEVD
---
---SETVAYHF
H
E
PLGV
V
G
Q
I
I
PWNFP
LL
M
AS
WK
MA
PALAAGN
C
VV
L
KP
A
R
L
TPL
S
V
L
LL
M
E
I
VG
D
L
-
L
P
P
GV
V
NVV
N
G
A
G
GEI
G
EY
L
A
T
SK
R
I
AK
V
A
F
TGS
TE
V
G
Q
Q
I
MQY
A
-
T
Q
NI
IP
V
T
LELGGKSP
N
I
F
FA
D
VM
D
EEDAF
F
D
K
A
LEGFALFAF-
N
Q
G
E
VC
TCPS
R
A
LVQESIY
E
R
F
MERAIRRVESI
R
S
G
NPLDSV
-
TQM
G
AQ
V
S
H
GQ
L
E
T
I
LNY
I
DI
G
KKE
G
-
AD
V
LT
G
G
RR
KLLE
G
-
E
L
K
D
GY
YLE
PT
I
LFG-QNNMR
V
FQ
EE
I
FGPVL
A
V
TTFKTM
EEA
L
EL
AND
T
QYGL
G
A
G
V
W
S
R
N
G
NL
A
Y
K
M
G
RG
IQ
A
G
RV
W
T
N
CYHAYPAHA
A
F
GG
Y
K
Q
SG
I
G
RET
H
KMM
L
EH
Y
QQT
K
C
L
L
VS
fig|444449.5.peg.3015
Escherichia coli O157:H7 str. EC4042 (19-503/512)
L
K
LKN
R
YD
N
F
I
G
G
EWVAPADG
---
EYYQNL
T
P
V
T
GQL
L
CEVAS
S
GKR
D
I
D
L
A
L
D
AA
HKV
K
--DK
W
AHTS
V
QD
R
AAI
L
F
K
IA
D
R
M
E
QNLE
L
L
A
T
A
E
AW
D
N
GK
PIRETSAA
DV
PLAIDHFR
Y
F
A
S
CIRAQE
G
GISEVD
---
---SETVAYHF
H
E
PLGV
V
G
Q
I
I
PWNFP
LL
M
AS
WK
MA
PALAAGN
C
VV
L
KP
A
R
L
TPL
S
V
L
LL
M
E
I
VG
D
L
-
L
P
P
GV
V
NVV
N
G
A
G
GEI
G
EY
L
A
T
SK
R
I
AK
V
A
F
TGS
TE
V
G
Q
Q
I
MQY
A
-
T
Q
NI
IP
V
T
LELGGKSP
N
I
F
FA
D
VM
D
EEDAF
F
D
K
A
LEGFALFAF-
N
Q
G
E
VC
TCPS
R
A
LVQESIY
E
R
F
MERAIRRVESI
R
S
G
NPLDSV
-
TQM
G
AQ
V
S
H
GQ
L
E
T
I
LNY
I
DI
G
KKE
G
-
AD
V
LT
G
G
RR
KLLE
G
-
E
L
K
D
GY
YLE
PT
I
LFG-QNNMR
V
FQ
EE
I
FGPVL
A
V
TTFKTM
EEA
L
EL
AND
T
QYGL
G
A
G
V
W
S
R
N
G
NL
A
Y
K
M
G
RG
IQ
A
G
RV
W
T
N
CYHAYPAHA
A
F
GG
Y
K
Q
SG
I
G
RET
H
KMM
L
EH
Y
QQT
K
C
L
L
VS
fig|444448.5.peg.1769
Escherichia coli O157:H7 str. EC4045 (19-503/512)
L
K
LKN
R
YD
N
F
I
G
G
EWVAPADG
---
EYYQNL
T
P
V
T
GQL
L
CEVAS
S
GKR
D
I
D
L
A
L
D
AA
HKV
K
--DK
W
AHTS
V
QD
R
AAI
L
F
K
IA
D
R
M
E
QNLE
L
L
A
T
A
E
AW
D
N
GK
PIRETSAA
DV
PLAIDHFR
Y
F
A
S
CIRAQE
G
GISEVD
---
---SETVAYHF
H
E
PLGV
V
G
Q
I
I
PWNFP
LL
M
AS
WK
MA
PALAAGN
C
VV
L
KP
A
R
L
TPL
S
V
L
LL
M
E
I
VG
D
L
-
L
P
P
GV
V
NVV
N
G
A
G
GEI
G
EY
L
A
T
SK
R
I
AK
V
A
F
TGS
TE
V
G
Q
Q
I
MQY
A
-
T
Q
NI
IP
V
T
LELGGKSP
N
I
F
FA
D
VM
D
EEDAF
F
D
K
A
LEGFALFAF-
N
Q
G
E
VC
TCPS
R
A
LVQESIY
E
R
F
MERAIRRVESI
R
S
G
NPLDSV
-
TQM
G
AQ
V
S
H
GQ
L
E
T
I
LNY
I
DI
G
KKE
G
-
AD
V
LT
G
G
RR
KLLE
G
-
E
L
K
D
GY
YLE
PT
I
LFG-QNNMR
V
FQ
EE
I
FGPVL
A
V
TTFKTM
EEA
L
EL
AND
T
QYGL
G
A
G
V
W
S
R
N
G
NL
A
Y
K
M
G
RG
IQ
A
G
RV
W
T
N
CYHAYPAHA
A
F
GG
Y
K
Q
SG
I
G
RET
H
KMM
L
EH
Y
QQT
K
C
L
L
VS
fig|444453.5.peg.1300
Escherichia coli O157:H7 str. EC4076 (19-503/512)
L
K
LKN
R
YD
N
F
I
G
G
EWVAPADG
---
EYYQNL
T
P
V
T
GQL
L
CEVAS
S
GKR
D
I
D
L
A
L
D
AA
HKV
K
--DK
W
AHTS
V
QD
R
AAI
L
F
K
IA
D
R
M
E
QNLE
L
L
A
T
A
E
AW
D
N
GK
PIRETSAA
DV
PLAIDHFR
Y
F
A
S
CIRAQE
G
GISEVD
---
---SETVAYHF
H
E
PLGV
V
G
Q
I
I
PWNFP
LL
M
AS
WK
MA
PALAAGN
C
VV
L
KP
A
R
L
TPL
S
V
L
LL
M
E
I
VG
D
L
-
L
P
P
GV
V
NVV
N
G
A
G
GEI
G
EY
L
A
T
SK
R
I
AK
V
A
F
TGS
TE
V
G
Q
Q
I
MQY
A
-
T
Q
NI
IP
V
T
LELGGKSP
N
I
F
FA
D
VM
D
EEDAF
F
D
K
A
LEGFALFAF-
N
Q
G
E
VC
TCPS
R
A
LVQESIY
E
R
F
MERAIRRVESI
R
S
G
NPLDSV
-
TQM
G
AQ
V
S
H
GQ
L
E
T
I
LNY
I
DI
G
KKE
G
-
AD
V
LT
G
G
RR
KLLE
G
-
E
L
K
D
GY
YLE
PT
I
LFG-QNNMR
V
FQ
EE
I
FGPVL
A
V
TTFKTM
EEA
L
EL
AND
T
QYGL
G
A
G
V
W
S
R
N
G
NL
A
Y
K
M
G
RG
IQ
A
G
RV
W
T
N
CYHAYPAHA
A
F
GG
Y
K
Q
SG
I
G
RET
H
KMM
L
EH
Y
QQT
K
C
L
L
VS
fig|444452.5.peg.42
Escherichia coli O157:H7 str. EC4113 (19-503/512)
L
K
LKN
R
YD
N
F
I
G
G
EWVAPADG
---
EYYQNL
T
P
V
T
GQL
L
CEVAS
S
GKR
D
I
D
L
A
L
D
AA
HKV
K
--DK
W
AHTS
V
QD
R
AAI
L
F
K
IA
D
R
M
E
QNLE
L
L
A
T
A
E
AW
D
N
GK
PIRETSAA
DV
PLAIDHFR
Y
F
A
S
CIRAQE
G
GISEVD
---
---SETVAYHF
H
E
PLGV
V
G
Q
I
I
PWNFP
LL
M
AS
WK
MA
PALAAGN
C
VV
L
KP
A
R
L
TPL
S
V
L
LL
M
E
I
VG
D
L
-
L
P
P
GV
V
NVV
N
G
A
G
GEI
G
EY
L
A
T
SK
R
I
AK
V
A
F
TGS
TE
V
G
Q
Q
I
MQY
A
-
T
Q
NI
IP
V
T
LELGGKSP
N
I
F
FA
D
VM
D
EEDAF
F
D
K
A
LEGFALFAF-
N
Q
G
E
VC
TCPS
R
A
LVQESIY
E
R
F
MERAIRRVESI
R
S
G
NPLDSV
-
TQM
G
AQ
V
S
H
GQ
L
E
T
I
LNY
I
DI
G
KKE
G
-
AD
V
LT
G
G
RR
KLLE
G
-
E
L
K
D
GY
YLE
PT
I
LFG-QNNMR
V
FQ
EE
I
FGPVL
A
V
TTFKTM
EEA
L
EL
AND
T
QYGL
G
A
G
V
W
S
R
N
G
NL
A
Y
K
M
G
RG
IQ
A
G
RV
W
T
N
CYHAYPAHA
A
F
GG
Y
K
Q
SG
I
G
RET
H
KMM
L
EH
Y
QQT
K
C
L
L
VS
fig|444450.8.peg.4850
Escherichia coli O157:H7 str. EC4115 (19-503/512)
L
K
LKN
R
YD
N
F
I
G
G
EWVAPADG
---
EYYQNL
T
P
V
T
GQL
L
CEVAS
S
GKR
D
I
D
L
A
L
D
AA
HKV
K
--DK
W
AHTS
V
QD
R
AAI
L
F
K
IA
D
R
M
E
QNLE
L
L
A
T
A
E
AW
D
N
GK
PIRETSAA
DV
PLAIDHFR
Y
F
A
S
CIRAQE
G
GISEVD
---
---SETVAYHF
H
E
PLGV
V
G
Q
I
I
PWNFP
LL
M
AS
WK
MA
PALAAGN
C
VV
L
KP
A
R
L
TPL
S
V
L
LL
M
E
I
VG
D
L
-
L
P
P
GV
V
NVV
N
G
A
G
GEI
G
EY
L
A
T
SK
R
I
AK
V
A
F
TGS
TE
V
G
Q
Q
I
MQY
A
-
T
Q
NI
IP
V
T
LELGGKSP
N
I
F
FA
D
VM
D
EEDAF
F
D
K
A
LEGFALFAF-
N
Q
G
E
VC
TCPS
R
A
LVQESIY
E
R
F
MERAIRRVESI
R
S
G
NPLDSV
-
TQM
G
AQ
V
S
H
GQ
L
E
T
I
LNY
I
DI
G
KKE
G
-
AD
V
LT
G
G
RR
KLLE
G
-
E
L
K
D
GY
YLE
PT
I
LFG-QNNMR
V
FQ
EE
I
FGPVL
A
V
TTFKTM
EEA
L
EL
AND
T
QYGL
G
A
G
V
W
S
R
N
G
NL
A
Y
K
M
G
RG
IQ
A
G
RV
W
T
N
CYHAYPAHA
A
F
GG
Y
K
Q
SG
I
G
RET
H
KMM
L
EH
Y
QQT
K
C
L
L
VS
fig|444451.5.peg.216
Escherichia coli O157:H7 str. EC4196 (19-503/512)
L
K
LKN
R
YD
N
F
I
G
G
EWVAPADG
---
EYYQNL
T
P
V
T
GQL
L
CEVAS
S
GKR
D
I
D
L
A
L
D
AA
HKV
K
--DK
W
AHTS
V
QD
R
AAI
L
F
K
IA
D
R
M
E
QNLE
L
L
A
T
A
E
AW
D
N
GK
PIRETSAA
DV
PLAIDHFR
Y
F
A
S
CIRAQE
G
GISEVD
---
---SETVAYHF
H
E
PLGV
V
G
Q
I
I
PWNFP
LL
M
AS
WK
MA
PALAAGN
C
VV
L
KP
A
R
L
TPL
S
V
L
LL
M
E
I
VG
D
L
-
L
P
P
GV
V
NVV
N
G
A
G
GEI
G
EY
L
A
T
SK
R
I
AK
V
A
F
TGS
TE
V
G
Q
Q
I
MQY
A
-
T
Q
NI
IP
V
T
LELGGKSP
N
I
F
FA
D
VM
D
EEDAF
F
D
K
A
LEGFALFAF-
N
Q
G
E
VC
TCPS
R
A
LVQESIY
E
R
F
MERAIRRVESI
R
S
G
NPLDSV
-
TQM
G
AQ
V
S
H
GQ
L
E
T
I
LNY
I
DI
G
KKE
G
-
AD
V
LT
G
G
RR
KLLE
G
-
E
L
K
D
GY
YLE
PT
I
LFG-QNNMR
V
FQ
EE
I
FGPVL
A
V
TTFKTM
EEA
L
EL
AND
T
QYGL
G
A
G
V
W
S
R
N
G
NL
A
Y
K
M
G
RG
IQ
A
G
RV
W
T
N
CYHAYPAHA
A
F
GG
Y
K
Q
SG
I
G
RET
H
KMM
L
EH
Y
QQT
K
C
L
L
VS
fig|444447.5.peg.1932
Escherichia coli O157:H7 str. EC4206 (19-503/512)
L
K
LKN
R
YD
N
F
I
G
G
EWVAPADG
---
EYYQNL
T
P
V
T
GQL
L
CEVAS
S
GKR
D
I
D
L
A
L
D
AA
HKV
K
--DK
W
AHTS
V
QD
R
AAI
L
F
K
IA
D
R
M
E
QNLE
L
L
A
T
A
E
AW
D
N
GK
PIRETSAA
DV
PLAIDHFR
Y
F
A
S
CIRAQE
G
GISEVD
---
---SETVAYHF
H
E
PLGV
V
G
Q
I
I
PWNFP
LL
M
AS
WK
MA
PALAAGN
C
VV
L
KP
A
R
L
TPL
S
V
L
LL
M
E
I
VG
D
L
-
L
P
P
GV
V
NVV
N
G
A
G
GEI
G
EY
L
A
T
SK
R
I
AK
V
A
F
TGS
TE
V
G
Q
Q
I
MQY
A
-
T
Q
NI
IP
V
T
LELGGKSP
N
I
F
FA
D
VM
D
EEDAF
F
D
K
A
LEGFALFAF-
N
Q
G
E
VC
TCPS
R
A
LVQESIY
E
R
F
MERAIRRVESI
R
S
G
NPLDSV
-
TQM
G
AQ
V
S
H
GQ
L
E
T
I
LNY
I
DI
G
KKE
G
-
AD
V
LT
G
G
RR
KLLE
G
-
E
L
K
D
GY
YLE
PT
I
LFG-QNNMR
V
FQ
EE
I
FGPVL
A
V
TTFKTM
EEA
L
EL
AND
T
QYGL
G
A
G
V
W
S
R
N
G
NL
A
Y
K
M
G
RG
IQ
A
G
RV
W
T
N
CYHAYPAHA
A
F
GG
Y
K
Q
SG
I
G
RET
H
KMM
L
EH
Y
QQT
K
C
L
L
VS
fig|478004.5.peg.326
Escherichia coli O157:H7 str. EC4401 (19-503/512)
L
K
LKN
R
YD
N
F
I
G
G
EWVAPADG
---
EYYQNL
T
P
V
T
GQL
L
CEVAS
S
GKR
D
I
D
L
A
L
D
AA
HKV
K
--DK
W
AHTS
V
QD
R
AAI
L
F
K
IA
D
R
M
E
QNLE
L
L
A
T
A
E
AW
D
N
GK
PIRETSAA
DV
PLAIDHFR
Y
F
A
S
CIRAQE
G
GISEVD
---
---SETVAYHF
H
E
PLGV
V
G
Q
I
I
PWNFP
LL
M
AS
WK
MA
PALAAGN
C
VV
L
KP
A
R
L
TPL
S
V
L
LL
M
E
I
VG
D
L
-
L
P
P
GV
V
NVV
N
G
A
G
GEI
G
EY
L
A
T
SK
R
I
AK
V
A
F
TGS
TE
V
G
Q
Q
I
MQY
A
-
T
Q
NI
IP
V
T
LELGGKSP
N
I
F
FA
D
VM
D
EEDAF
F
D
K
A
LEGFALFAF-
N
Q
G
E
VC
TCPS
R
A
LVQESIY
E
R
F
MERAIRRVESI
R
S
G
NPLDSV
-
TQM
G
AQ
V
S
H
GQ
L
E
T
I
LNY
I
DI
G
KKE
G
-
AD
V
LT
G
G
RR
KLLE
G
-
E
L
K
D
GY
YLE
PT
I
LFG-QNNMR
V
FQ
EE
I
FGPVL
A
V
TTFKTM
EEA
L
EL
AND
T
QYGL
G
A
G
V
W
S
R
N
G
NL
A
Y
K
M
G
RG
IQ
A
G
RV
W
T
N
CYHAYPAHA
A
F
GG
Y
K
Q
SG
I
G
RET
H
KMM
L
EH
Y
QQT
K
C
L
L
VS
fig|478005.5.peg.279
Escherichia coli O157:H7 str. EC4486 (19-503/512)
L
K
LKN
R
YD
N
F
I
G
G
EWVAPADG
---
EYYQNL
T
P
V
T
GQL
L
CEVAS
S
GKR
D
I
D
L
A
L
D
AA
HKV
K
--DK
W
AHTS
V
QD
R
AAI
L
F
K
IA
D
R
M
E
QNLE
L
L
A
T
A
E
AW
D
N
GK
PIRETSAA
DV
PLAIDHFR
Y
F
A
S
CIRAQE
G
GISEVD
---
---SETVAYHF
H
E
PLGV
V
G
Q
I
I
PWNFP
LL
M
AS
WK
MA
PALAAGN
C
VV
L
KP
A
R
L
TPL
S
V
L
LL
M
E
I
VG
D
L
-
L
P
P
GV
V
NVV
N
G
A
G
GEI
G
EY
L
A
T
SK
R
I
AK
V
A
F
TGS
TE
V
G
Q
Q
I
MQY
A
-
T
Q
NI
IP
V
T
LELGGKSP
N
I
F
FA
D
VM
D
EEDAF
F
D
K
A
LEGFALFAF-
N
Q
G
E
VC
TCPS
R
A
LVQESIY
E
R
F
MERAIRRVESI
R
S
G
NPLDSV
-
TQM
G
AQ
V
S
H
GQ
L
E
T
I
LNY
I
DI
G
KKE
G
-
AD
V
LT
G
G
RR
KLLE
G
-
E
L
K
D
GY
YLE
PT
I
LFG-QNNMR
V
FQ
EE
I
FGPVL
A
V
TTFKTM
EEA
L
EL
AND
T
QYGL
G
A
G
V
W
S
R
N
G
NL
A
Y
K
M
G
RG
IQ
A
G
RV
W
T
N
CYHAYPAHA
A
F
GG
Y
K
Q
SG
I
G
RET
H
KMM
L
EH
Y
QQT
K
C
L
L
VS
fig|478006.5.peg.292
Escherichia coli O157:H7 str. EC4501 (19-503/512)
L
K
LKN
R
YD
N
F
I
G
G
EWVAPADG
---
EYYQNL
T
P
V
T
GQL
L
CEVAS
S
GKR
D
I
D
L
A
L
D
AA
HKV
K
--DK
W
AHTS
V
QD
R
AAI
L
F
K
IA
D
R
M
E
QNLE
L
L
A
T
A
E
AW
D
N
GK
PIRETSAA
DV
PLAIDHFR
Y
F
A
S
CIRAQE
G
GISEVD
---
---SETVAYHF
H
E
PLGV
V
G
Q
I
I
PWNFP
LL
M
AS
WK
MA
PALAAGN
C
VV
L
KP
A
R
L
TPL
S
V
L
LL
M
E
I
VG
D
L
-
L
P
P
GV
V
NVV
N
G
A
G
GEI
G
EY
L
A
T
SK
R
I
AK
V
A
F
TGS
TE
V
G
Q
Q
I
MQY
A
-
T
Q
NI
IP
V
T
LELGGKSP
N
I
F
FA
D
VM
D
EEDAF
F
D
K
A
LEGFALFAF-
N
Q
G
E
VC
TCPS
R
A
LVQESIY
E
R
F
MERAIRRVESI
R
S
G
NPLDSV
-
TQM
G
AQ
V
S
H
GQ
L
E
T
I
LNY
I
DI
G
KKE
G
-
AD
V
LT
G
G
RR
KLLE
G
-
E
L
K
D
GY
YLE
PT
I
LFG-QNNMR
V
FQ
EE
I
FGPVL
A
V
TTFKTM
EEA
L
EL
AND
T
QYGL
G
A
G
V
W
S
R
N
G
NL
A
Y
K
M
G
RG
IQ
A
G
RV
W
T
N
CYHAYPAHA
A
F
GG
Y
K
Q
SG
I
G
RET
H
KMM
L
EH
Y
QQT
K
C
L
L
VS
fig|478008.5.peg.821
Escherichia coli O157:H7 str. EC869 (19-503/512)
L
K
LKN
R
YD
N
F
I
G
G
EWVAPADG
---
EYYQNL
T
P
V
T
GQL
L
CEVAS
S
GKR
D
I
D
L
A
L
D
AA
HKV
K
--DK
W
AHTS
V
QD
R
AAI
L
F
K
IA
D
R
M
E
QNLE
L
L
A
T
A
E
AW
D
N
GK
PIRETSAA
DV
PLAIDHFR
Y
F
A
S
CIRAQE
G
GISEVD
---
---SETVAYHF
H
E
PLGV
V
G
Q
I
I
PWNFP
LL
M
AS
WK
MA
PALAAGN
C
VV
L
KP
A
R
L
TPL
S
V
L
LL
M
E
I
VG
D
L
-
L
P
P
GV
V
NVV
N
G
A
G
GEI
G
EY
L
A
T
SK
R
I
AK
V
A
F
TGS
TE
V
G
Q
Q
I
MQY
A
-
T
Q
NI
IP
V
T
LELGGKSP
N
I
F
FA
D
VM
D
EEDAF
F
D
K
A
LEGFALFAF-
N
Q
G
E
VC
TCPS
R
A
LVQESIY
E
R
F
MERAIRRVESI
R
S
G
NPLDSV
-
TQM
G
AQ
V
S
H
GQ
L
E
T
I
LNY
I
DI
G
KKE
G
-
AD
V
LT
G
G
RR
KLLE
G
-
E
L
K
D
GY
YLE
PT
I
LFG-QNNMR
V
FQ
EE
I
FGPVL
A
V
TTFKTM
EEA
L
EL
AND
T
QYGL
G
A
G
V
W
S
R
N
G
NL
A
Y
K
M
G
RG
IQ
A
G
RV
W
T
N
CYHAYPAHA
A
F
GG
Y
K
Q
SG
I
G
RET
H
KMM
L
EH
Y
QQT
K
C
L
L
VS
fig|637388.3.peg.2013
Escherichia coli O157:H7 str. FRIK2000 (19-503/512)
L
K
LKN
R
YD
N
F
I
G
G
EWVAPADG
---
EYYQNL
T
P
V
T
GQL
L
CEVAS
S
GKR
D
I
D
L
A
L
D
AA
HKV
K
--DK
W
AHTS
V
QD
R
AAI
L
F
K
IA
D
R
M
E
QNLE
L
L
A
T
A
E
AW
D
N
GK
PIRETSAA
DV
PLAIDHFR
Y
F
A
S
CIRAQE
G
GISEVD
---
---SETVAYHF
H
E
PLGV
V
G
Q
I
I
PWNFP
LL
M
AS
WK
MA
PALAAGN
C
VV
L
KP
A
R
L
TPL
S
V
L
LL
M
E
I
VG
D
L
-
L
P
P
GV
V
NVV
N
G
A
G
GEI
G
EY
L
A
T
SK
R
I
AK
V
A
F
TGS
TE
V
G
Q
Q
I
MQY
A
-
T
Q
NI
IP
V
T
LELGGKSP
N
I
F
FA
D
VM
D
EEDAF
F
D
K
A
LEGFALFAF-
N
Q
G
E
VC
TCPS
R
A
LVQESIY
E
R
F
MERAIRRVESI
R
S
G
NPLDSV
-
TQM
G
AQ
V
S
H
GQ
L
E
T
I
LNY
I
DI
G
KKE
G
-
AD
V
LT
G
G
RR
KLLE
G
-
E
L
K
D
GY
YLE
PT
I
LFG-QNNMR
V
FQ
EE
I
FGPVL
A
V
TTFKTM
EEA
L
EL
AND
T
QYGL
G
A
G
V
W
S
R
N
G
NL
A
Y
K
M
G
RG
IQ
A
G
RV
W
T
N
CYHAYPAHA
A
F
GG
Y
K
Q
SG
I
G
RET
H
KMM
L
EH
Y
QQT
K
C
L
L
VS
fig|570506.3.peg.9
Escherichia coli O157:H7 str. FRIK966 (19-503/512)
L
K
LKN
R
YD
N
F
I
G
G
EWVAPADG
---
EYYQNL
T
P
V
T
GQL
L
CEVAS
S
GKR
D
I
D
L
A
L
D
AA
HKV
K
--DK
W
AHTS
V
QD
R
AAI
L
F
K
IA
D
R
M
E
QNLE
L
L
A
T
A
E
AW
D
N
GK
PIRETSAA
DV
PLAIDHFR
Y
F
A
S
CIRAQE
G
GISEVD
---
---SETVAYHF
H
E
PLGV
V
G
Q
I
I
PWNFP
LL
M
AS
WK
MA
PALAAGN
C
VV
L
KP
A
R
L
TPL
S
V
L
LL
M
E
I
VG
D
L
-
L
P
P
GV
V
NVV
N
G
A
G
GEI
G
EY
L
A
T
SK
R
I
AK
V
A
F
TGS
TE
V
G
Q
Q
I
MQY
A
-
T
Q
NI
IP
V
T
LELGGKSP
N
I
F
FA
D
VM
D
EEDAF
F
D
K
A
LEGFALFAF-
N
Q
G
E
VC
TCPS
R
A
LVQESIY
E
R
F
MERAIRRVESI
R
S
G
NPLDSV
-
TQM
G
AQ
V
S
H
GQ
L
E
T
I
LNY
I
DI
G
KKE
G
-
AD
V
LT
G
G
RR
KLLE
G
-
E
L
K
D
GY
YLE
PT
I
LFG-QNNMR
V
FQ
EE
I
FGPVL
A
V
TTFKTM
EEA
L
EL
AND
T
QYGL
G
A
G
V
W
S
R
N
G
NL
A
Y
K
M
G
RG
IQ
A
G
RV
W
T
N
CYHAYPAHA
A
F
GG
Y
K
Q
SG
I
G
RET
H
KMM
L
EH
Y
QQT
K
C
L
L
VS
fig|386585.9.peg.4675
Escherichia coli O157:H7 str. Sakai (19-503/512)
L
K
LKN
R
YD
N
F
I
G
G
EWVAPADG
---
EYYQNL
T
P
V
T
GQL
L
CEVAS
S
GKR
D
I
D
L
A
L
D
AA
HKV
K
--DK
W
AHTS
V
QD
R
AAI
L
F
K
IA
D
R
M
E
QNLE
L
L
A
T
A
E
AW
D
N
GK
PIRETSAA
DV
PLAIDHFR
Y
F
A
S
CIRAQE
G
GISEVD
---
---SETVAYHF
H
E
PLGV
V
G
Q
I
I
PWNFP
LL
M
AS
WK
MA
PALAAGN
C
VV
L
KP
A
R
L
TPL
S
V
L
LL
M
E
I
VG
D
L
-
L
P
P
GV
V
NVV
N
G
A
G
GEI
G
EY
L
A
T
SK
R
I
AK
V
A
F
TGS
TE
V
G
Q
Q
I
MQY
A
-
T
Q
NI
IP
V
T
LELGGKSP
N
I
F
FA
D
VM
D
EEDAF
F
D
K
A
LEGFALFAF-
N
Q
G
E
VC
TCPS
R
A
LVQESIY
E
R
F
MERAIRRVESI
R
S
G
NPLDSV
-
TQM
G
AQ
V
S
H
GQ
L
E
T
I
LNY
I
DI
G
KKE
G
-
AD
V
LT
G
G
RR
KLLE
G
-
E
L
K
D
GY
YLE
PT
I
LFG-QNNMR
V
FQ
EE
I
FGPVL
A
V
TTFKTM
EEA
L
EL
AND
T
QYGL
G
A
G
V
W
S
R
N
G
NL
A
Y
K
M
G
RG
IQ
A
G
RV
W
T
N
CYHAYPAHA
A
F
GG
Y
K
Q
SG
I
G
RET
H
KMM
L
EH
Y
QQT
K
C
L
L
VS
fig|544404.4.peg.4661
Escherichia coli O157:H7 str. TW14359 (19-503/512)
L
K
LKN
R
YD
N
F
I
G
G
EWVAPADG
---
EYYQNL
T
P
V
T
GQL
L
CEVAS
S
GKR
D
I
D
L
A
L
D
AA
HKV
K
--DK
W
AHTS
V
QD
R
AAI
L
F
K
IA
D
R
M
E
QNLE
L
L
A
T
A
E
AW
D
N
GK
PIRETSAA
DV
PLAIDHFR
Y
F
A
S
CIRAQE
G
GISEVD
---
---SETVAYHF
H
E
PLGV
V
G
Q
I
I
PWNFP
LL
M
AS
WK
MA
PALAAGN
C
VV
L
KP
A
R
L
TPL
S
V
L
LL
M
E
I
VG
D
L
-
L
P
P
GV
V
NVV
N
G
A
G
GEI
G
EY
L
A
T
SK
R
I
AK
V
A
F
TGS
TE
V
G
Q
Q
I
MQY
A
-
T
Q
NI
IP
V
T
LELGGKSP
N
I
F
FA
D
VM
D
EEDAF
F
D
K
A
LEGFALFAF-
N
Q
G
E
VC
TCPS
R
A
LVQESIY
E
R
F
MERAIRRVESI
R
S
G
NPLDSV
-
TQM
G
AQ
V
S
H
GQ
L
E
T
I
LNY
I
DI
G
KKE
G
-
AD
V
LT
G
G
RR
KLLE
G
-
E
L
K
D
GY
YLE
PT
I
LFG-QNNMR
V
FQ
EE
I
FGPVL
A
V
TTFKTM
EEA
L
EL
AND
T
QYGL
G
A
G
V
W
S
R
N
G
NL
A
Y
K
M
G
RG
IQ
A
G
RV
W
T
N
CYHAYPAHA
A
F
GG
Y
K
Q
SG
I
G
RET
H
KMM
L
EH
Y
QQT
K
C
L
L
VS
fig|502346.5.peg.2167
Escherichia coli O157:H7 str. TW14588 (19-503/512)
L
K
LKN
R
YD
N
F
I
G
G
EWVAPADG
---
EYYQNL
T
P
V
T
GQL
L
CEVAS
S
GKR
D
I
D
L
A
L
D
AA
HKV
K
--DK
W
AHTS
V
QD
R
AAI
L
F
K
IA
D
R
M
E
QNLE
L
L
A
T
A
E
AW
D
N
GK
PIRETSAA
DV
PLAIDHFR
Y
F
A
S
CIRAQE
G
GISEVD
---
---SETVAYHF
H
E
PLGV
V
G
Q
I
I
PWNFP
LL
M
AS
WK
MA
PALAAGN
C
VV
L
KP
A
R
L
TPL
S
V
L
LL
M
E
I
VG
D
L
-
L
P
P
GV
V
NVV
N
G
A
G
GEI
G
EY
L
A
T
SK
R
I
AK
V
A
F
TGS
TE
V
G
Q
Q
I
MQY
A
-
T
Q
NI
IP
V
T
LELGGKSP
N
I
F
FA
D
VM
D
EEDAF
F
D
K
A
LEGFALFAF-
N
Q
G
E
VC
TCPS
R
A
LVQESIY
E
R
F
MERAIRRVESI
R
S
G
NPLDSV
-
TQM
G
AQ
V
S
H
GQ
L
E
T
I
LNY
I
DI
G
KKE
G
-
AD
V
LT
G
G
RR
KLLE
G
-
E
L
K
D
GY
YLE
PT
I
LFG-QNNMR
V
FQ
EE
I
FGPVL
A
V
TTFKTM
EEA
L
EL
AND
T
QYGL
G
A
G
V
W
S
R
N
G
NL
A
Y
K
M
G
RG
IQ
A
G
RV
W
T
N
CYHAYPAHA
A
F
GG
Y
K
Q
SG
I
G
RET
H
KMM
L
EH
Y
QQT
K
C
L
L
VS
fig|749546.3.peg.77
Escherichia coli MS 185-1 (1-483/490)
M
S
RMA
E
QQ
L
Y
I
H
G
GYTPATSG
---
RTFETI
NPA
N
GNV
L
ATVQA
A
GRE
D
V
D
R
AV
K
S
A
QQG
Q
--KI
W
AAMT
A
ME
R
SRI
L
R
R
AV
D
I
L
R
ERND
E
L
A
K
LE
TL
D
T
GK
AYSETSTV
D
I
VTGADVLE
Y
Y
AG
LIPALE
G
---SQI
---
PLRETSFVYTR
R
E
PLGV
V
A
G
I
G
A
WN
Y
P
IQ
I
AL
WK
SA
PALAAGN
A
M
I
F
KPSE
V
TPLTAL
KL
A
E
I
YS
EAG
L
P
D
GV
F
NV
L
P
G
V
G
AET
G
QY
LT
D
HP
G
I
AK
VS
F
TG
G
VA
S
GK
K
V
MAN
S
A
A
S
SL
K
E
V
T
M
ELGGKSP
L
IV
FD
D
-
AD
-----
L
D
L
A
ADIAMMANFF
S
S
GQVC
TNGT
RV
FVPTKCK
A
A
F
EQKVLARVERI
R
A
G
DVFDPQ
-
TNF
GPL
V
S
F
P
H
R
D
N
V
LRY
I
AK
G
KEE
G
-
AR
V
LC
G
G
--
NVLK
G
D
S
F
D
N
G
A
WVA
PT
V
FTDCSDDMT
I
VR
EE
I
FGPV
M
S
I
LTYESE
D
E
V
I
RR
AND
T
D
YGL
A
A
G
I
V
T
A
DL
NR
A
H
R
V
I
HQ
L
E
A
G
IC
W
I
N
TWGESPAEI
P
V
GG
Y
K
H
SG
I
G
REN
G
VMT
L
QS
Y
TQV
K
S
I
Q
V
E
M
fig|478007.5.peg.299
Escherichia coli O157:H7 str. EC508 (19-503/512)
L
K
LKN
R
YD
N
F
I
G
G
EWVAPADG
---
EYYQNL
T
P
V
T
GQL
L
CEVAS
S
GKR
D
I
D
L
A
L
D
AA
HKV
K
--DK
W
AHTS
V
QD
R
AAI
L
F
K
IA
D
R
M
E
QNLE
L
L
A
T
A
E
AW
D
N
GK
PIRETSAA
DV
PLAIDHFR
Y
F
A
S
CIRAQE
G
GISEVD
---
---SETVAYHF
H
E
PLGV
V
G
Q
I
I
PWNFP
LL
M
AS
WK
MA
PALAAGN
C
VV
L
KP
A
R
L
TPL
S
V
L
LL
M
E
I
VG
D
L
-
L
P
P
GV
V
NVV
N
G
A
G
GEI
G
EY
L
A
T
LK
R
I
AK
V
A
F
TGS
TE
V
G
Q
Q
I
MQY
A
-
T
Q
NI
IP
V
T
LELGGKSP
N
I
F
FA
D
VM
D
EEDAF
F
D
K
A
LEGFALFAF-
N
Q
G
E
VC
TCPS
R
A
LVQESIY
E
R
F
MERAIRRVESI
R
S
G
NPLDSV
-
TQM
G
AQ
V
S
H
GQ
L
E
T
I
LNY
I
DI
G
KKE
G
-
AD
V
LT
G
G
RR
KLLE
G
-
E
L
K
D
GY
YLE
PT
I
LFG-QNNMR
V
FQ
EE
I
FGPVL
A
V
TTFKTM
EEA
L
EL
AND
T
QYGL
G
A
G
V
W
S
R
N
G
NL
A
Y
K
M
G
RG
IQ
A
G
RV
W
T
N
CYHAYPAHA
A
F
GG
Y
K
Q
SG
I
G
RET
H
KMM
L
EH
Y
QQT
K
C
L
L
VS
fig|358709.5.peg.2904
Escherichia coli 101-1 (1-483/490)
M
S
RMA
E
QQ
L
Y
I
H
G
GYTSATSG
---
RTFETI
NPA
N
GNV
L
ATVQA
A
GRE
D
V
D
R
AV
K
S
A
QQG
Q
--KI
W
AAMT
A
ME
R
SRI
L
R
R
AV
D
I
L
R
ERND
E
L
A
K
LE
TL
D
T
GK
AYSETSTV
D
I
VTGADVLE
Y
Y
AG
LIPALE
G
---SQI
---
PLRETSFVYTR
R
E
PLGV
V
A
G
I
G
A
WN
Y
P
IQ
I
AL
WK
SA
PALAAGN
A
M
I
F
KPSE
V
TPLTAL
KL
A
E
I
YS
EAG
L
P
D
GV
F
NV
L
P
G
V
G
AET
G
QY
LT
E
HP
G
I
AK
VS
F
TG
G
VA
S
GK
K
V
MAN
S
A
A
S
SL
K
E
V
T
M
ELGGKSP
L
IV
FD
D
-
AD
-----
L
D
L
A
ADIAMMANFF
S
S
GQVC
TNGT
RV
FVPAKCK
A
A
F
EQKILARVERI
R
A
G
DVFDPQ
-
TNF
GPL
V
S
F
P
H
R
D
N
V
LRY
I
VK
G
KEE
G
-
AR
V
LC
G
G
--
DVLK
G
D
D
F
D
N
G
A
WVA
PT
V
FTDCSDDMT
I
VR
EE
I
FGPV
M
S
I
LTYESE
D
E
V
I
RR
AND
T
D
YGL
A
A
G
I
V
T
A
DL
NR
A
H
R
V
I
HQ
L
E
A
G
IC
W
I
N
TWGESPAEM
P
V
GG
Y
K
H
SG
I
G
REN
G
VMT
L
QS
Y
TQV
K
S
I
Q
V
E
M
fig|413997.3.peg.287
Escherichia coli B str. REL606 (1-483/490)
M
S
RMA
E
QQ
L
Y
I
H
G
GYTSATSG
---
RTFETI
NPA
N
GNV
L
ATVQA
A
GRE
D
V
D
R
AV
K
S
A
QQG
Q
--KI
W
AAMT
A
ME
R
SRI
L
R
R
AV
D
I
L
R
ERND
E
L
A
K
LE
TL
D
T
GK
AYSETSTV
D
I
VTGADVLE
Y
Y
AG
LIPALE
G
---SQI
---
PLRETSFVYTR
R
E
PLGV
V
A
G
I
G
A
WN
Y
P
IQ
I
AL
WK
SA
PALAAGN
A
M
I
F
KPSE
V
TPLTAL
KL
A
E
I
YS
EAG
L
P
D
GV
F
NV
L
P
G
V
G
AET
G
QY
LT
E
HP
G
I
AK
VS
F
TG
G
VA
S
GK
K
V
MAN
S
A
A
S
SL
K
E
V
T
M
ELGGKSP
L
IV
FD
D
-
AD
-----
L
D
L
A
ADIAMMANFF
S
S
GQVC
TNGT
RV
FVPAKCK
A
A
F
EQKILARVERI
R
A
G
DVFDPQ
-
TNF
GPL
V
S
F
P
H
R
D
N
V
LRY
I
VK
G
KEE
G
-
AR
V
LC
G
G
--
DVLK
G
D
D
F
D
N
G
A
WVA
PT
V
FTDCSDDMT
I
VR
EE
I
FGPV
M
S
I
LTYESE
D
E
V
I
RR
AND
T
D
YGL
A
A
G
I
V
T
A
DL
NR
A
H
R
V
I
HQ
L
E
A
G
IC
W
I
N
TWGESPAEM
P
V
GG
Y
K
H
SG
I
G
REN
G
VMT
L
QS
Y
TQV
K
S
I
Q
V
E
M
fig|511693.5.peg.288
Escherichia coli BL21 (1-483/490)
M
S
RMA
E
QQ
L
Y
I
H
G
GYTSATSG
---
RTFETI
NPA
N
GNV
L
ATVQA
A
GRE
D
V
D
R
AV
K
S
A
QQG
Q
--KI
W
AAMT
A
ME
R
SRI
L
R
R
AV
D
I
L
R
ERND
E
L
A
K
LE
TL
D
T
GK
AYSETSTV
D
I
VTGADVLE
Y
Y
AG
LIPALE
G
---SQI
---
PLRETSFVYTR
R
E
PLGV
V
A
G
I
G
A
WN
Y
P
IQ
I
AL
WK
SA
PALAAGN
A
M
I
F
KPSE
V
TPLTAL
KL
A
E
I
YS
EAG
L
P
D
GV
F
NV
L
P
G
V
G
AET
G
QY
LT
E
HP
G
I
AK
VS
F
TG
G
VA
S
GK
K
V
MAN
S
A
A
S
SL
K
E
V
T
M
ELGGKSP
L
IV
FD
D
-
AD
-----
L
D
L
A
ADIAMMANFF
S
S
GQVC
TNGT
RV
FVPAKCK
A
A
F
EQKILARVERI
R
A
G
DVFDPQ
-
TNF
GPL
V
S
F
P
H
R
D
N
V
LRY
I
VK
G
KEE
G
-
AR
V
LC
G
G
--
DVLK
G
D
D
F
D
N
G
A
WVA
PT
V
FTDCSDDMT
I
VR
EE
I
FGPV
M
S
I
LTYESE
D
E
V
I
RR
AND
T
D
YGL
A
A
G
I
V
T
A
DL
NR
A
H
R
V
I
HQ
L
E
A
G
IC
W
I
N
TWGESPAEM
P
V
GG
Y
K
H
SG
I
G
REN
G
VMT
L
QS
Y
TQV
K
S
I
Q
V
E
M
fig|469008.4.peg.3456
Escherichia coli BL21(DE3) (1-483/490)
M
S
RMA
E
QQ
L
Y
I
H
G
GYTSATSG
---
RTFETI
NPA
N
GNV
L
ATVQA
A
GRE
D
V
D
R
AV
K
S
A
QQG
Q
--KI
W
AAMT
A
ME
R
SRI
L
R
R
AV
D
I
L
R
ERND
E
L
A
K
LE
TL
D
T
GK
AYSETSTV
D
I
VTGADVLE
Y
Y
AG
LIPALE
G
---SQI
---
PLRETSFVYTR
R
E
PLGV
V
A
G
I
G
A
WN
Y
P
IQ
I
AL
WK
SA
PALAAGN
A
M
I
F
KPSE
V
TPLTAL
KL
A
E
I
YS
EAG
L
P
D
GV
F
NV
L
P
G
V
G
AET
G
QY
LT
E
HP
G
I
AK
VS
F
TG
G
VA
S
GK
K
V
MAN
S
A
A
S
SL
K
E
V
T
M
ELGGKSP
L
IV
FD
D
-
AD
-----
L
D
L
A
ADIAMMANFF
S
S
GQVC
TNGT
RV
FVPAKCK
A
A
F
EQKILARVERI
R
A
G
DVFDPQ
-
TNF
GPL
V
S
F
P
H
R
D
N
V
LRY
I
VK
G
KEE
G
-
AR
V
LC
G
G
--
DVLK
G
D
D
F
D
N
G
A
WVA
PT
V
FTDCSDDMT
I
VR
EE
I
FGPV
M
S
I
LTYESE
D
E
V
I
RR
AND
T
D
YGL
A
A
G
I
V
T
A
DL
NR
A
H
R
V
I
HQ
L
E
A
G
IC
W
I
N
TWGESPAEM
P
V
GG
Y
K
H
SG
I
G
REN
G
VMT
L
QS
Y
TQV
K
S
I
Q
V
E
M
fig|749547.3.peg.16
Escherichia coli MS 187-1 (1-483/490)
M
S
RMA
E
QQ
L
Y
I
H
G
GYTSATSG
---
RTFETI
NPA
N
GNV
L
ATVQA
A
GRE
D
V
D
R
AV
K
S
A
QQG
Q
--KI
W
AAMT
A
ME
R
SRI
L
R
R
AV
D
I
L
R
ERND
E
L
A
K
LE
TL
D
T
GK
AYSETSTV
D
I
VTGADVLE
Y
Y
AG
LIPALE
G
---SQI
---
PLRETSFVYTR
R
E
PLGV
V
A
G
I
G
A
WN
Y
P
IQ
I
AL
WK
SA
PALAAGN
A
M
I
F
KPSE
V
TPLTAL
KL
A
E
I
YS
EAG
L
P
D
GV
F
NV
L
P
G
V
G
AET
G
QY
LT
E
HP
G
I
AK
VS
F
TG
G
VA
S
GK
K
V
MAN
S
A
A
S
SL
K
E
V
T
M
ELGGKSP
L
IV
FD
D
-
AD
-----
L
D
L
A
ADIAMMANFF
S
S
GQVC
TNGT
RV
FVPAKCK
A
A
F
EQKILARVERI
R
A
G
DVFDPQ
-
TNF
GPL
V
S
F
P
H
R
D
N
V
LRY
I
VK
G
KEE
G
-
AR
V
LC
G
G
--
DVLK
G
D
D
F
D
N
G
A
WVA
PT
V
FTDCSDDMT
I
VR
EE
I
FGPV
M
S
I
LTYESE
D
E
V
I
RR
AND
T
D
YGL
A
A
G
I
V
T
A
DL
NR
A
H
R
V
I
HQ
L
E
A
G
IC
W
I
N
TWGESPAEM
P
V
GG
Y
K
H
SG
I
G
REN
G
VMT
L
QS
Y
TQV
K
S
I
Q
V
E
M
fig|431946.3.peg.298
Escherichia coli SE15 (1-483/490)
M
S
RMA
E
QQ
L
Y
I
H
G
GYTSATSG
---
RTFETI
NPA
N
GNV
L
ATVQA
A
GRE
D
V
D
R
AV
K
S
A
QQG
Q
--KI
W
AAMT
A
ME
R
SRI
L
R
R
AV
D
I
L
R
ERND
E
L
A
K
LE
TL
D
T
GK
AYSETSTV
D
I
VTGADVLE
Y
Y
AG
LIPALE
G
---SQI
---
PLRETSFVYTR
R
E
PLGV
V
A
G
I
G
A
WN
Y
P
IQ
I
AL
WK
SA
PALAAGN
A
M
I
F
KPSE
V
TPLTAL
KL
A
E
I
YS
EAG
L
P
D
GV
F
NV
L
P
G
V
G
AET
G
QY
LT
D
HP
G
I
AK
VS
F
TG
G
VA
S
GK
K
V
MAN
S
A
A
S
SL
K
E
V
T
M
ELGGKSP
L
IV
FD
D
-
AD
-----
L
D
L
A
ADIAMMANFF
S
S
GQVC
TNGT
RV
FVPTKCK
A
A
F
EQKVLARVERI
R
A
G
DVFDPQ
-
TNF
GPL
V
S
F
P
H
R
D
N
V
LRY
I
AK
G
KEE
G
-
AR
V
LC
G
G
--
NVLK
G
D
S
F
D
N
G
A
WVA
PT
V
FTDCSDDMT
I
VR
EE
I
FGPV
M
S
I
LIYESE
D
E
V
I
RR
AND
T
D
YGL
A
A
G
I
V
T
A
DL
NR
A
H
R
V
I
HQ
L
E
A
G
IC
W
I
N
TWGESPAEM
P
V
GG
Y
K
H
SG
I
G
REN
G
VMT
L
QS
Y
TQV
K
S
I
Q
V
E
M
fig|749527.3.peg.4440
Escherichia coli MS 21-1 (1-483/490)
M
S
RMA
E
QQ
L
Y
I
H
G
GYTSATSG
---
RTFETI
NPA
N
GNV
L
ATVQA
A
GRE
D
V
D
R
AV
K
S
A
QQG
Q
--KI
W
AAMT
A
ME
R
SRI
L
R
R
AV
D
I
L
R
ERND
E
L
A
K
LE
TL
D
T
GK
AYSETSTV
D
I
VTGADVLE
Y
Y
AG
LIPALE
G
---SQI
---
PLRETSFVYTR
R
E
PLGV
V
A
G
I
G
A
WN
Y
P
IQ
I
AL
WK
SA
PALAAGN
A
M
I
F
KPSE
V
TPLTAL
KL
A
D
I
YS
EAG
L
P
D
GV
F
NV
L
P
G
V
G
AET
G
QY
LT
E
HP
G
I
AK
VS
F
TG
G
VA
S
GK
K
V
MAN
S
A
A
S
SL
K
E
V
T
M
ELGGKSP
L
IV
FD
D
-
AD
-----
L
D
L
A
ADIAMMANFF
S
S
GQVC
TNGT
RV
FVPTKCK
A
A
F
EQKILARVERI
R
A
G
DVFDPQ
-
TNF
GPL
V
S
F
P
H
R
D
N
V
LRY
I
AK
G
KEE
G
-
AR
V
LC
G
G
--
DVLK
G
D
S
F
D
N
G
A
WVA
PT
V
FTDCSDDMT
I
VR
EE
I
FGPV
M
S
L
LTYESE
D
E
V
I
RR
AND
T
D
YGL
A
A
G
I
V
T
A
DL
NR
A
H
R
V
I
HQ
L
E
A
G
IC
W
I
N
TWGESPAEM
P
V
GG
Y
K
H
SG
I
G
REN
G
VMT
L
QS
Y
TQV
K
S
I
Q
V
E
M
fig|536056.3.peg.3484
Escherichia coli DH1 (1-483/490)
M
S
RMA
E
QQ
L
Y
I
H
G
GYTSATSG
---
RTFETI
NPA
N
GNV
L
ATVQA
A
GRE
D
V
D
R
AV
K
S
A
QQG
Q
--KI
W
ASMT
A
ME
R
SRI
L
R
R
AV
D
I
L
R
ERND
E
L
A
K
LE
TL
D
T
GK
AYSETSTV
D
I
VTGADVLE
Y
Y
AG
LIPALE
G
---SQI
---
PLRETSFVYTR
R
E
PLGV
V
A
G
I
G
A
WN
Y
P
IQ
I
AL
WK
SA
PALAAGN
A
M
I
F
KPSE
V
TPLTAL
KL
A
E
I
YS
EAG
L
P
D
GV
F
NV
L
P
G
V
G
AET
G
QY
LT
E
HP
G
I
AK
VS
F
TG
G
VA
S
GK
K
V
MAN
S
A
A
S
SL
K
E
V
T
M
ELGGKSP
L
IV
FD
D
-
AD
-----
L
D
L
A
ADIAMMANFF
S
S
GQVC
TNGT
RV
FVPAKCK
A
A
F
EQKILARVERI
R
A
G
DVFDPQ
-
TNF
GPL
V
S
F
P
H
R
D
N
V
LRY
I
AK
G
KEE
G
-
AR
V
LC
G
G
--
DVLK
G
DG
F
D
N
G
A
WVA
PT
V
FTDCSDDMT
I
VR
EE
I
FGPV
M
S
I
LTYESE
D
E
V
I
RR
AND
T
D
YGL
A
A
G
I
V
T
A
DL
NR
A
H
R
V
I
HQ
L
E
A
G
IC
W
I
N
TWGESPAEM
P
V
GG
Y
K
H
SG
I
G
REN
G
VMT
L
QS
Y
TQV
K
S
I
Q
V
E
M
fig|316401.4.peg.426
Escherichia coli ETEC H10407 (1-483/490)
M
S
RMA
E
QQ
L
Y
I
H
G
GYTSATSG
---
RTFETI
NPA
N
GNV
L
ATVQA
A
GRE
D
V
D
R
AV
K
S
A
QQG
Q
--KI
W
ASMT
A
ME
R
SRI
L
R
R
AV
D
I
L
R
ERND
E
L
A
K
LE
TL
D
T
GK
AYSETSTV
D
I
VTGADVLE
Y
Y
AG
LIPALE
G
---SQI
---
PLRETSFVYTR
R
E
PLGV
V
A
G
I
G
A
WN
Y
P
IQ
I
AL
WK
SA
PALAAGN
A
M
I
F
KPSE
V
TPLTAL
KL
A
E
I
YS
EAG
L
P
D
GV
F
NV
L
P
G
V
G
AET
G
QY
LT
E
HP
G
I
AK
VS
F
TG
G
VA
S
GK
K
V
MAN
S
A
A
S
SL
K
E
V
T
M
ELGGKSP
L
IV
FD
D
-
AD
-----
L
D
L
A
ADIAMMANFF
S
S
GQVC
TNGT
RV
FVPAKCK
A
A
F
EQKILARVERI
R
A
G
DVFDPQ
-
TNF
GPL
V
S
F
P
H
R
D
N
V
LRY
I
AK
G
KEE
G
-
AR
V
LC
G
G
--
DVLK
G
DG
F
D
N
G
A
WVA
PT
V
FTDCSDDMT
I
VR
EE
I
FGPV
M
S
I
LTYESE
D
E
V
I
RR
AND
T
D
YGL
A
A
G
I
V
T
A
DL
NR
A
H
R
V
I
HQ
L
E
A
G
IC
W
I
N
TWGESPAEM
P
V
GG
Y
K
H
SG
I
G
REN
G
VMT
L
QS
Y
TQV
K
S
I
Q
V
E
M
fig|656414.3.peg.499
Escherichia coli H736 (1-483/490)
M
S
RMA
E
QQ
L
Y
I
H
G
GYTSATSG
---
RTFETI
NPA
N
GNV
L
ATVQA
A
GRE
D
V
D
R
AV
K
S
A
QQG
Q
--KI
W
ASMT
A
ME
R
SRI
L
R
R
AV
D
I
L
R
ERND
E
L
A
K
LE
TL
D
T
GK
AYSETSTV
D
I
VTGADVLE
Y
Y
AG
LIPALE
G
---SQI
---
PLRETSFVYTR
R
E
PLGV
V
A
G
I
G
A
WN
Y
P
IQ
I
AL
WK
SA
PALAAGN
A
M
I
F
KPSE
V
TPLTAL
KL
A
E
I
YS
EAG
L
P
D
GV
F
NV
L
P
G
V
G
AET
G
QY
LT
E
HP
G
I
AK
VS
F
TG
G
VA
S
GK
K
V
MAN
S
A
A
S
SL
K
E
V
T
M
ELGGKSP
L
IV
FD
D
-
AD
-----
L
D
L
A
ADIAMMANFF
S
S
GQVC
TNGT
RV
FVPAKCK
A
A
F
EQKILARVERI
R
A
G
DVFDPQ
-
TNF
GPL
V
S
F
P
H
R
D
N
V
LRY
I
AK
G
KEE
G
-
AR
V
LC
G
G
--
DVLK
G
DG
F
D
N
G
A
WVA
PT
V
FTDCSDDMT
I
VR
EE
I
FGPV
M
S
I
LTYESE
D
E
V
I
RR
AND
T
D
YGL
A
A
G
I
V
T
A
DL
NR
A
H
R
V
I
HQ
L
E
A
G
IC
W
I
N
TWGESPAEM
P
V
GG
Y
K
H
SG
I
G
REN
G
VMT
L
QS
Y
TQV
K
S
I
Q
V
E
M
fig|83333.1.peg.309
Escherichia coli K12 (1-483/490)
M
S
RMA
E
QQ
L
Y
I
H
G
GYTSATSG
---
RTFETI
NPA
N
GNV
L
ATVQA
A
GRE
D
V
D
R
AV
K
S
A
QQG
Q
--KI
W
ASMT
A
ME
R
SRI
L
R
R
AV
D
I
L
R
ERND
E
L
A
K
LE
TL
D
T
GK
AYSETSTV
D
I
VTGADVLE
Y
Y
AG
LIPALE
G
---SQI
---
PLRETSFVYTR
R
E
PLGV
V
A
G
I
G
A
WN
Y
P
IQ
I
AL
WK
SA
PALAAGN
A
M
I
F
KPSE
V
TPLTAL
KL
A
E
I
YS
EAG
L
P
D
GV
F
NV
L
P
G
V
G
AET
G
QY
LT
E
HP
G
I
AK
VS
F
TG
G
VA
S
GK
K
V
MAN
S
A
A
S
SL
K
E
V
T
M
ELGGKSP
L
IV
FD
D
-
AD
-----
L
D
L
A
ADIAMMANFF
S
S
GQVC
TNGT
RV
FVPAKCK
A
A
F
EQKILARVERI
R
A
G
DVFDPQ
-
TNF
GPL
V
S
F
P
H
R
D
N
V
LRY
I
AK
G
KEE
G
-
AR
V
LC
G
G
--
DVLK
G
DG
F
D
N
G
A
WVA
PT
V
FTDCSDDMT
I
VR
EE
I
FGPV
M
S
I
LTYESE
D
E
V
I
RR
AND
T
D
YGL
A
A
G
I
V
T
A
DL
NR
A
H
R
V
I
HQ
L
E
A
G
IC
W
I
N
TWGESPAEM
P
V
GG
Y
K
H
SG
I
G
REN
G
VMT
L
QS
Y
TQV
K
S
I
Q
V
E
M
fig|749537.3.peg.378
Escherichia coli MS 115-1 (1-483/490)
M
S
RMA
E
QQ
L
Y
I
H
G
GYTSATSG
---
RTFETI
NPA
N
GNV
L
ATVQA
A
GRE
D
V
D
R
AV
K
S
A
QQG
Q
--KI
W
ASMT
A
ME
R
SRI
L
R
R
AV
D
I
L
R
ERND
E
L
A
K
LE
TL
D
T
GK
AYSETSTV
D
I
VTGADVLE
Y
Y
AG
LIPALE
G
---SQI
---
PLRETSFVYTR
R
E
PLGV
V
A
G
I
G
A
WN
Y
P
IQ
I
AL
WK
SA
PALAAGN
A
M
I
F
KPSE
V
TPLTAL
KL
A
E
I
YS
EAG
L
P
D
GV
F
NV
L
P
G
V
G
AET
G
QY
LT
E
HP
G
I
AK
VS
F
TG
G
VA
S
GK
K
V
MAN
S
A
A
S
SL
K
E
V
T
M
ELGGKSP
L
IV
FD
D
-
AD
-----
L
D
L
A
ADIAMMANFF
S
S
GQVC
TNGT
RV
FVPAKCK
A
A
F
EQKILARVERI
R
A
G
DVFDPQ
-
TNF
GPL
V
S
F
P
H
R
D
N
V
LRY
I
AK
G
KEE
G
-
AR
V
LC
G
G
--
DVLK
G
DG
F
D
N
G
A
WVA
PT
V
FTDCSDDMT
I
VR
EE
I
FGPV
M
S
I
LTYESE
D
E
V
I
RR
AND
T
D
YGL
A
A
G
I
V
T
A
DL
NR
A
H
R
V
I
HQ
L
E
A
G
IC
W
I
N
TWGESPAEM
P
V
GG
Y
K
H
SG
I
G
REN
G
VMT
L
QS
Y
TQV
K
S
I
Q
V
E
M
fig|749538.3.peg.89
Escherichia coli MS 116-1 (1-483/490)
M
S
RMA
E
QQ
L
Y
I
H
G
GYTSATSG
---
RTFETI
NPA
N
GNV
L
ATVQA
A
GRE
D
V
D
R
AV
K
S
A
QQG
Q
--KI
W
ASMT
A
ME
R
SRI
L
R
R
AV
D
I
L
R
ERND
E
L
A
K
LE
TL
D
T
GK
AYSETSTV
D
I
VTGADVLE
Y
Y
AG
LIPALE
G
---SQI
---
PLRETSFVYTR
R
E
PLGV
V
A
G
I
G
A
WN
Y
P
IQ
I
AL
WK
SA
PALAAGN
A
M
I
F
KPSE
V
TPLTAL
KL
A
E
I
YS
EAG
L
P
D
GV
F
NV
L
P
G
V
G
AET
G
QY
LT
E
HP
G
I
AK
VS
F
TG
G
VA
S
GK
K
V
MAN
S
A
A
S
SL
K
E
V
T
M
ELGGKSP
L
IV
FD
D
-
AD
-----
L
D
L
A
ADIAMMANFF
S
S
GQVC
TNGT
RV
FVPAKCK
A
A
F
EQKILARVERI
R
A
G
DVFDPQ
-
TNF
GPL
V
S
F
P
H
R
D
N
V
LRY
I
AK
G
KEE
G
-
AR
V
LC
G
G
--
DVLK
G
DG
F
D
N
G
A
WVA
PT
V
FTDCSDDMT
I
VR
EE
I
FGPV
M
S
I
LTYESE
D
E
V
I
RR
AND
T
D
YGL
A
A
G
I
V
T
A
DL
NR
A
H
R
V
I
HQ
L
E
A
G
IC
W
I
N
TWGESPAEM
P
V
GG
Y
K
H
SG
I
G
REN
G
VMT
L
QS
Y
TQV
K
S
I
Q
V
E
M
fig|749544.3.peg.1297
Escherichia coli MS 175-1 (1-483/490)
M
S
RMA
E
QQ
L
Y
I
H
G
GYTSATSG
---
RTFETI
NPA
N
GNV
L
ATVQA
A
GRE
D
V
D
R
AV
K
S
A
QQG
Q
--KI
W
ASMT
A
ME
R
SRI
L
R
R
AV
D
I
L
R
ERND
E
L
A
K
LE
TL
D
T
GK
AYSETSTV
D
I
VTGADVLE
Y
Y
AG
LIPALE
G
---SQI
---
PLRETSFVYTR
R
E
PLGV
V
A
G
I
G
A
WN
Y
P
IQ
I
AL
WK
SA
PALAAGN
A
M
I
F
KPSE
V
TPLTAL
KL
A
E
I
YS
EAG
L
P
D
GV
F
NV
L
P
G
V
G
AET
G
QY
LT
E
HP
G
I
AK
VS
F
TG
G
VA
S
GK
K
V
MAN
S
A
A
S
SL
K
E
V
T
M
ELGGKSP
L
IV
FD
D
-
AD
-----
L
D
L
A
ADIAMMANFF
S
S
GQVC
TNGT
RV
FVPAKCK
A
A
F
EQKILARVERI
R
A
G
DVFDPQ
-
TNF
GPL
V
S
F
P
H
R
D
N
V
LRY
I
AK
G
KEE
G
-
AR
V
LC
G
G
--
DVLK
G
DG
F
D
N
G
A
WVA
PT
V
FTDCSDDMT
I
VR
EE
I
FGPV
M
S
I
LTYESE
D
E
V
I
RR
AND
T
D
YGL
A
A
G
I
V
T
A
DL
NR
A
H
R
V
I
HQ
L
E
A
G
IC
W
I
N
TWGESPAEM
P
V
GG
Y
K
H
SG
I
G
REN
G
VMT
L
QS
Y
TQV
K
S
I
Q
V
E
M
fig|316407.3.peg.301
Escherichia coli W3110 (1-483/490)
M
S
RMA
E
QQ
L
Y
I
H
G
GYTSATSG
---
RTFETI
NPA
N
GNV
L
ATVQA
A
GRE
D
V
D
R
AV
K
S
A
QQG
Q
--KI
W
ASMT
A
ME
R
SRI
L
R
R
AV
D
I
L
R
ERND
E
L
A
K
LE
TL
D
T
GK
AYSETSTV
D
I
VTGADVLE
Y
Y
AG
LIPALE
G
---SQI
---
PLRETSFVYTR
R
E
PLGV
V
A
G
I
G
A
WN
Y
P
IQ
I
AL
WK
SA
PALAAGN
A
M
I
F
KPSE
V
TPLTAL
KL
A
E
I
YS
EAG
L
P
D
GV
F
NV
L
P
G
V
G
AET
G
QY
LT
E
HP
G
I
AK
VS
F
TG
G
VA
S
GK
K
V
MAN
S
A
A
S
SL
K
E
V
T
M
ELGGKSP
L
IV
FD
D
-
AD
-----
L
D
L
A
ADIAMMANFF
S
S
GQVC
TNGT
RV
FVPAKCK
A
A
F
EQKILARVERI
R
A
G
DVFDPQ
-
TNF
GPL
V
S
F
P
H
R
D
N
V
LRY
I
AK
G
KEE
G
-
AR
V
LC
G
G
--
DVLK
G
DG
F
D
N
G
A
WVA
PT
V
FTDCSDDMT
I
VR
EE
I
FGPV
M
S
I
LTYESE
D
E
V
I
RR
AND
T
D
YGL
A
A
G
I
V
T
A
DL
NR
A
H
R
V
I
HQ
L
E
A
G
IC
W
I
N
TWGESPAEM
P
V
GG
Y
K
H
SG
I
G
REN
G
VMT
L
QS
Y
TQV
K
S
I
Q
V
E
M
fig|316385.7.peg.298
Escherichia coli str. K-12 substr. DH10B (1-483/490)
M
S
RMA
E
QQ
L
Y
I
H
G
GYTSATSG
---
RTFETI
NPA
N
GNV
L
ATVQA
A
GRE
D
V
D
R
AV
K
S
A
QQG
Q
--KI
W
ASMT
A
ME
R
SRI
L
R
R
AV
D
I
L
R
ERND
E
L
A
K
LE
TL
D
T
GK
AYSETSTV
D
I
VTGADVLE
Y
Y
AG
LIPALE
G
---SQI
---
PLRETSFVYTR
R
E
PLGV
V
A
G
I
G
A
WN
Y
P
IQ
I
AL
WK
SA
PALAAGN
A
M
I
F
KPSE
V
TPLTAL
KL
A
E
I
YS
EAG
L
P
D
GV
F
NV
L
P
G
V
G
AET
G
QY
LT
E
HP
G
I
AK
VS
F
TG
G
VA
S
GK
K
V
MAN
S
A
A
S
SL
K
E
V
T
M
ELGGKSP
L
IV
FD
D
-
AD
-----
L
D
L
A
ADIAMMANFF
S
S
GQVC
TNGT
RV
FVPAKCK
A
A
F
EQKILARVERI
R
A
G
DVFDPQ
-
TNF
GPL
V
S
F
P
H
R
D
N
V
LRY
I
AK
G
KEE
G
-
AR
V
LC
G
G
--
DVLK
G
DG
F
D
N
G
A
WVA
PT
V
FTDCSDDMT
I
VR
EE
I
FGPV
M
S
I
LTYESE
D
E
V
I
RR
AND
T
D
YGL
A
A
G
I
V
T
A
DL
NR
A
H
R
V
I
HQ
L
E
A
G
IC
W
I
N
TWGESPAEM
P
V
GG
Y
K
H
SG
I
G
REN
G
VMT
L
QS
Y
TQV
K
S
I
Q
V
E
M
fig|511145.12.peg.319
Escherichia coli str. K-12 substr. MG1655 (1-483/490)
M
S
RMA
E
QQ
L
Y
I
H
G
GYTSATSG
---
RTFETI
NPA
N
GNV
L
ATVQA
A
GRE
D
V
D
R
AV
K
S
A
QQG
Q
--KI
W
ASMT
A
ME
R
SRI
L
R
R
AV
D
I
L
R
ERND
E
L
A
K
LE
TL
D
T
GK
AYSETSTV
D
I
VTGADVLE
Y
Y
AG
LIPALE
G
---SQI
---
PLRETSFVYTR
R
E
PLGV
V
A
G
I
G
A
WN
Y
P
IQ
I
AL
WK
SA
PALAAGN
A
M
I
F
KPSE
V
TPLTAL
KL
A
E
I
YS
EAG
L
P
D
GV
F
NV
L
P
G
V
G
AET
G
QY
LT
E
HP
G
I
AK
VS
F
TG
G
VA
S
GK
K
V
MAN
S
A
A
S
SL
K
E
V
T
M
ELGGKSP
L
IV
FD
D
-
AD
-----
L
D
L
A
ADIAMMANFF
S
S
GQVC
TNGT
RV
FVPAKCK
A
A
F
EQKILARVERI
R
A
G
DVFDPQ
-
TNF
GPL
V
S
F
P
H
R
D
N
V
LRY
I
AK
G
KEE
G
-
AR
V
LC
G
G
--
DVLK
G
DG
F
D
N
G
A
WVA
PT
V
FTDCSDDMT
I
VR
EE
I
FGPV
M
S
I
LTYESE
D
E
V
I
RR
AND
T
D
YGL
A
A
G
I
V
T
A
DL
NR
A
H
R
V
I
HQ
L
E
A
G
IC
W
I
N
TWGESPAEM
P
V
GG
Y
K
H
SG
I
G
REN
G
VMT
L
QS
Y
TQV
K
S
I
Q
V
E
M
fig|511145.6.peg.317
Escherichia coli str. K-12 substr. MG1655 (1-483/490)
M
S
RMA
E
QQ
L
Y
I
H
G
GYTSATSG
---
RTFETI
NPA
N
GNV
L
ATVQA
A
GRE
D
V
D
R
AV
K
S
A
QQG
Q
--KI
W
ASMT
A
ME
R
SRI
L
R
R
AV
D
I
L
R
ERND
E
L
A
K
LE
TL
D
T
GK
AYSETSTV
D
I
VTGADVLE
Y
Y
AG
LIPALE
G
---SQI
---
PLRETSFVYTR
R
E
PLGV
V
A
G
I
G
A
WN
Y
P
IQ
I
AL
WK
SA
PALAAGN
A
M
I
F
KPSE
V
TPLTAL
KL
A
E
I
YS
EAG
L
P
D
GV
F
NV
L
P
G
V
G
AET
G
QY
LT
E
HP
G
I
AK
VS
F
TG
G
VA
S
GK
K
V
MAN
S
A
A
S
SL
K
E
V
T
M
ELGGKSP
L
IV
FD
D
-
AD
-----
L
D
L
A
ADIAMMANFF
S
S
GQVC
TNGT
RV
FVPAKCK
A
A
F
EQKILARVERI
R
A
G
DVFDPQ
-
TNF
GPL
V
S
F
P
H
R
D
N
V
LRY
I
AK
G
KEE
G
-
AR
V
LC
G
G
--
DVLK
G
DG
F
D
N
G
A
WVA
PT
V
FTDCSDDMT
I
VR
EE
I
FGPV
M
S
I
LTYESE
D
E
V
I
RR
AND
T
D
YGL
A
A
G
I
V
T
A
DL
NR
A
H
R
V
I
HQ
L
E
A
G
IC
W
I
N
TWGESPAEM
P
V
GG
Y
K
H
SG
I
G
REN
G
VMT
L
QS
Y
TQV
K
S
I
Q
V
E
M
fig|749548.3.peg.83
Escherichia coli MS 196-1 (1-483/490)
M
S
RMA
E
QQ
L
Y
I
H
G
GYTSATSG
---
RTFETI
NPA
N
GNV
L
ATVQA
A
GRE
D
V
D
R
AV
K
S
A
QQG
Q
--KI
W
ASMT
A
ME
R
SRI
L
R
R
AV
D
I
L
R
ERND
E
L
A
K
LE
TL
D
T
GK
AYSETSTV
D
I
VTGADVLE
Y
Y
AG
LIPALE
G
---SQI
---
PLRETSFVYTR
R
E
PLGV
V
A
G
I
G
A
WN
Y
P
IQ
I
AL
WK
SA
PALAAGN
A
M
I
F
KPSE
V
TPLTAL
KL
A
E
I
YS
EAG
L
P
D
GV
F
NV
L
P
G
V
G
AET
G
QY
LT
E
HP
G
I
AK
VS
F
TG
G
VA
S
GK
K
V
MAN
S
A
A
S
SL
K
E
V
T
M
ELGGKSP
L
IV
FD
D
-
AD
-----
L
D
L
A
ADIAMMANFF
S
S
GQVC
TNGT
RV
FVPAKCK
A
A
F
EQKILARVERI
R
A
G
DVFDPQ
-
TNF
GPL
V
S
F
P
H
R
D
N
V
LRY
I
AK
G
KEE
G
-
AR
V
LC
G
G
--
DVLK
G
DG
F
N
N
G
A
WVA
PT
V
FTDCSDDMT
I
VR
EE
I
FGPV
M
S
I
LTYESE
D
E
V
I
RR
AND
T
D
YGL
A
A
G
I
V
T
A
DL
NR
A
H
R
V
I
HQ
L
E
A
G
IC
W
I
N
TWGESPAEM
P
V
GG
Y
K
H
SG
I
G
REN
G
VMT
L
QS
Y
TQV
K
S
I
Q
V
E
M
fig|562.371.peg.1227
Escherichia coli 1044A (1-483/490)
M
S
RMA
E
QQ
L
Y
I
H
G
GYTSATSG
---
RTFETI
NPA
N
GNV
L
ATVQA
A
GRE
D
V
D
R
AV
K
S
A
QQG
Q
--KI
W
AAMT
A
ME
R
SRI
L
R
R
AV
D
I
L
R
ERND
E
L
A
K
LE
TL
D
T
GK
AYSETSTV
D
I
VTGADVLE
Y
Y
AG
LIPSLE
G
---SQI
---
PLRETSFVYTR
R
E
PLGV
V
A
G
I
G
A
WN
Y
P
IQ
I
AL
WK
SA
PALAAGN
A
M
I
F
KPSE
V
TPLTAL
KL
A
E
I
YS
EAG
L
P
D
GV
F
NV
L
P
G
V
G
AET
G
QY
LT
E
HP
G
I
AK
VS
F
TG
G
VA
S
GK
K
V
MAN
S
A
A
S
SL
K
E
V
T
M
ELGGKSP
L
IV
FD
D
-
AD
-----
L
D
L
A
ADIAMMANFF
S
S
GQVC
TNGT
RV
FVPAKCN
A
A
F
EQKILARVERI
R
A
G
DVFDPQ
-
TNF
GPL
V
S
F
P
H
R
D
N
V
LRY
I
AK
G
KEE
G
-
AR
V
LC
G
G
--
DVLK
G
DG
L
D
N
G
A
WVA
PT
V
FTDCSDEMT
I
VR
EE
I
FGPV
M
S
I
LTYESE
D
E
V
I
RR
AND
T
D
YGL
A
A
G
I
V
T
A
DL
NR
A
H
R
V
I
HQ
L
E
A
G
IC
W
I
N
TWGESPAEM
P
V
GG
Y
K
H
SG
I
G
REN
G
VMT
L
QS
Y
TQV
K
S
I
Q
V
E
M
fig|562.373.peg.502
Escherichia coli 1125A (1-483/490)
M
S
RMA
E
QQ
L
Y
I
H
G
GYTSATSG
---
RTFETI
NPA
N
GNV
L
ATVQA
A
GRE
D
V
D
R
AV
K
S
A
QQG
Q
--KI
W
AAMT
A
ME
R
SRI
L
R
R
AV
D
I
L
R
ERND
E
L
A
K
LE
TL
D
T
GK
AYSETSTV
D
I
VTGADVLE
Y
Y
AG
LIPSLE
G
---SQI
---
PLRETSFVYTR
R
E
PLGV
V
A
G
I
G
A
WN
Y
P
IQ
I
AL
WK
SA
PALAAGN
A
M
I
F
KPSE
V
TPLTAL
KL
A
E
I
YS
EAG
L
P
D
GV
F
NV
L
P
G
V
G
AET
G
QY
LT
E
HP
G
I
AK
VS
F
TG
G
VA
S
GK
K
V
MAN
S
A
A
S
SL
K
E
V
T
M
ELGGKSP
L
IV
FD
D
-
AD
-----
L
D
L
A
ADIAMMANFF
S
S
GQVC
TNGT
RV
FVPAKCN
A
A
F
EQKILARVERI
R
A
G
DVFDPQ
-
TNF
GPL
V
S
F
P
H
R
D
N
V
LRY
I
AK
G
KEE
G
-
AR
V
LC
G
G
--
DVLK
G
DG
L
D
N
G
A
WVA
PT
V
FTDCSDEMT
I
VR
EE
I
FGPV
M
S
I
LTYESE
D
E
V
I
RR
AND
T
D
YGL
A
A
G
I
V
T
A
DL
NR
A
H
R
V
I
HQ
L
E
A
G
IC
W
I
N
TWGESPAEM
P
V
GG
Y
K
H
SG
I
G
REN
G
VMT
L
QS
Y
TQV
K
S
I
Q
V
E
M
fig|562.372.peg.679
Escherichia coli 1212A (1-483/490)
M
S
RMA
E
QQ
L
Y
I
H
G
GYTSATSG
---
RTFETI
NPA
N
GNV
L
ATVQA
A
GRE
D
V
D
R
AV
K
S
A
QQG
Q
--KI
W
AAMT
A
ME
R
SRI
L
R
R
AV
D
I
L
R
ERND
E
L
A
K
LE
TL
D
T
GK
AYSETSTV
D
I
VTGADVLE
Y
Y
AG
LIPSLE
G
---SQI
---
PLRETSFVYTR
R
E
PLGV
V
A
G
I
G
A
WN
Y
P
IQ
I
AL
WK
SA
PALAAGN
A
M
I
F
KPSE
V
TPLTAL
KL
A
E
I
YS
EAG
L
P
D
GV
F
NV
L
P
G
V
G
AET
G
QY
LT
E
HP
G
I
AK
VS
F
TG
G
VA
S
GK
K
V
MAN
S
A
A
S
SL
K
E
V
T
M
ELGGKSP
L
IV
FD
D
-
AD
-----
L
D
L
A
ADIAMMANFF
S
S
GQVC
TNGT
RV
FVPAKCN
A
A
F
EQKILARVERI
R
A
G
DVFDPQ
-
TNF
GPL
V
S
F
P
H
R
D
N
V
LRY
I
AK
G
KEE
G
-
AR
V
LC
G
G
--
DVLK
G
DG
L
D
N
G
A
WVA
PT
V
FTDCSDEMT
I
VR
EE
I
FGPV
M
S
I
LTYESE
D
E
V
I
RR
AND
T
D
YGL
A
A
G
I
V
T
A
DL
NR
A
H
R
V
I
HQ
L
E
A
G
IC
W
I
N
TWGESPAEM
P
V
GG
Y
K
H
SG
I
G
REN
G
VMT
L
QS
Y
TQV
K
S
I
Q
V
E
M
fig|562.374.peg.1261
Escherichia coli 536A (1-483/490)
M
S
RMA
E
QQ
L
Y
I
H
G
GYTSATSG
---
RTFETI
NPA
N
GNV
L
ATVQA
A
GRE
D
V
D
R
AV
K
S
A
QQG
Q
--KI
W
AAMT
A
ME
R
SRI
L
R
R
AV
D
I
L
R
ERND
E
L
A
K
LE
TL
D
T
GK
AYSETSTV
D
I
VTGADVLE
Y
Y
AG
LIPSLE
G
---SQI
---
PLRETSFVYTR
R
E
PLGV
V
A
G
I
G
A
WN
Y
P
IQ
I
AL
WK
SA
PALAAGN
A
M
I
F
KPSE
V
TPLTAL
KL
A
E
I
YS
EAG
L
P
D
GV
F
NV
L
P
G
V
G
AET
G
QY
LT
E
HP
G
I
AK
VS
F
TG
G
VA
S
GK
K
V
MAN
S
A
A
S
SL
K
E
V
T
M
ELGGKSP
L
IV
FD
D
-
AD
-----
L
D
L
A
ADIAMMANFF
S
S
GQVC
TNGT
RV
FVPAKCN
A
A
F
EQKILARVERI
R
A
G
DVFDPQ
-
TNF
GPL
V
S
F
P
H
R
D
N
V
LRY
I
AK
G
KEE
G
-
AR
V
LC
G
G
--
DVLK
G
DG
L
D
N
G
A
WVA
PT
V
FTDCSDEMT
I
VR
EE
I
FGPV
M
S
I
LTYESE
D
E
V
I
RR
AND
T
D
YGL
A
A
G
I
V
T
A
DL
NR
A
H
R
V
I
HQ
L
E
A
G
IC
W
I
N
TWGESPAEM
P
V
GG
Y
K
H
SG
I
G
REN
G
VMT
L
QS
Y
TQV
K
S
I
Q
V
E
M
fig|155864.1.peg.354
Escherichia coli O157:H7 EDL933 (1-483/490)
M
S
RMA
E
QQ
L
Y
I
H
G
GYTSATSG
---
RTFETI
NPA
N
GNV
L
ATVQA
A
GRE
D
V
D
R
AV
K
S
A
QQG
Q
--KI
W
AAMT
A
ME
R
SRI
L
R
R
AV
D
I
L
R
ERND
E
L
A
K
LE
TL
D
T
GK
AYSETSTV
D
I
VTGADVLE
Y
Y
AG
LIPSLE
G
---SQI
---
PLRETSFVYTR
R
E
PLGV
V
A
G
I
G
A
WN
Y
P
IQ
I
AL
WK
SA
PALAAGN
A
M
I
F
KPSE
V
TPLTAL
KL
A
E
I
YS
EAG
L
P
D
GV
F
NV
L
P
G
V
G
AET
G
QY
LT
E
HP
G
I
AK
VS
F
TG
G
VA
S
GK
K
V
MAN
S
A
A
S
SL
K
E
V
T
M
ELGGKSP
L
IV
FD
D
-
AD
-----
L
D
L
A
ADIAMMANFF
S
S
GQVC
TNGT
RV
FVPAKCN
A
A
F
EQKILARVERI
R
A
G
DVFDPQ
-
TNF
GPL
V
S
F
P
H
R
D
N
V
LRY
I
AK
G
KEE
G
-
AR
V
LC
G
G
--
DVLK
G
DG
L
D
N
G
A
WVA
PT
V
FTDCSDEMT
I
VR
EE
I
FGPV
M
S
I
LTYESE
D
E
V
I
RR
AND
T
D
YGL
A
A
G
I
V
T
A
DL
NR
A
H
R
V
I
HQ
L
E
A
G
IC
W
I
N
TWGESPAEM
P
V
GG
Y
K
H
SG
I
G
REN
G
VMT
L
QS
Y
TQV
K
S
I
Q
V
E
M
fig|155864.8.peg.349
Escherichia coli O157:H7 EDL933 (1-483/490)
M
S
RMA
E
QQ
L
Y
I
H
G
GYTSATSG
---
RTFETI
NPA
N
GNV
L
ATVQA
A
GRE
D
V
D
R
AV
K
S
A
QQG
Q
--KI
W
AAMT
A
ME
R
SRI
L
R
R
AV
D
I
L
R
ERND
E
L
A
K
LE
TL
D
T
GK
AYSETSTV
D
I
VTGADVLE
Y
Y
AG
LIPSLE
G
---SQI
---
PLRETSFVYTR
R
E
PLGV
V
A
G
I
G
A
WN
Y
P
IQ
I
AL
WK
SA
PALAAGN
A
M
I
F
KPSE
V
TPLTAL
KL
A
E
I
YS
EAG
L
P
D
GV
F
NV
L
P
G
V
G
AET
G
QY
LT
E
HP
G
I
AK
VS
F
TG
G
VA
S
GK
K
V
MAN
S
A
A
S
SL
K
E
V
T
M
ELGGKSP
L
IV
FD
D
-
AD
-----
L
D
L
A
ADIAMMANFF
S
S
GQVC
TNGT
RV
FVPAKCN
A
A
F
EQKILARVERI
R
A
G
DVFDPQ
-
TNF
GPL
V
S
F
P
H
R
D
N
V
LRY
I
AK
G
KEE
G
-
AR
V
LC
G
G
--
DVLK
G
DG
L
D
N
G
A
WVA
PT
V
FTDCSDEMT
I
VR
EE
I
FGPV
M
S
I
LTYESE
D
E
V
I
RR
AND
T
D
YGL
A
A
G
I
V
T
A
DL
NR
A
H
R
V
I
HQ
L
E
A
G
IC
W
I
N
TWGESPAEM
P
V
GG
Y
K
H
SG
I
G
REN
G
VMT
L
QS
Y
TQV
K
S
I
Q
V
E
M
fig|444454.5.peg.4819
Escherichia coli O157:H7 str. EC4024 (1-483/490)
M
S
RMA
E
QQ
L
Y
I
H
G
GYTSATSG
---
RTFETI
NPA
N
GNV
L
ATVQA
A
GRE
D
V
D
R
AV
K
S
A
QQG
Q
--KI
W
AAMT
A
ME
R
SRI
L
R
R
AV
D
I
L
R
ERND
E
L
A
K
LE
TL
D
T
GK
AYSETSTV
D
I
VTGADVLE
Y
Y
AG
LIPSLE
G
---SQI
---
PLRETSFVYTR
R
E
PLGV
V
A
G
I
G
A
WN
Y
P
IQ
I
AL
WK
SA
PALAAGN
A
M
I
F
KPSE
V
TPLTAL
KL
A
E
I
YS
EAG
L
P
D
GV
F
NV
L
P
G
V
G
AET
G
QY
LT
E
HP
G
I
AK
VS
F
TG
G
VA
S
GK
K
V
MAN
S
A
A
S
SL
K
E
V
T
M
ELGGKSP
L
IV
FD
D
-
AD
-----
L
D
L
A
ADIAMMANFF
S
S
GQVC
TNGT
RV
FVPAKCN
A
A
F
EQKILARVERI
R
A
G
DVFDPQ
-
TNF
GPL
V
S
F
P
H
R
D
N
V
LRY
I
AK
G
KEE
G
-
AR
V
LC
G
G
--
DVLK
G
DG
L
D
N
G
A
WVA
PT
V
FTDCSDEMT
I
VR
EE
I
FGPV
M
S
I
LTYESE
D
E
V
I
RR
AND
T
D
YGL
A
A
G
I
V
T
A
DL
NR
A
H
R
V
I
HQ
L
E
A
G
IC
W
I
N
TWGESPAEM
P
V
GG
Y
K
H
SG
I
G
REN
G
VMT
L
QS
Y
TQV
K
S
I
Q
V
E
M
fig|444449.5.peg.5160
Escherichia coli O157:H7 str. EC4042 (1-483/490)
M
S
RMA
E
QQ
L
Y
I
H
G
GYTSATSG
---
RTFETI
NPA
N
GNV
L
ATVQA
A
GRE
D
V
D
R
AV
K
S
A
QQG
Q
--KI
W
AAMT
A
ME
R
SRI
L
R
R
AV
D
I
L
R
ERND
E
L
A
K
LE
TL
D
T
GK
AYSETSTV
D
I
VTGADVLE
Y
Y
AG
LIPSLE
G
---SQI
---
PLRETSFVYTR
R
E
PLGV
V
A
G
I
G
A
WN
Y
P
IQ
I
AL
WK
SA
PALAAGN
A
M
I
F
KPSE
V
TPLTAL
KL
A
E
I
YS
EAG
L
P
D
GV
F
NV
L
P
G
V
G
AET
G
QY
LT
E
HP
G
I
AK
VS
F
TG
G
VA
S
GK
K
V
MAN
S
A
A
S
SL
K
E
V
T
M
ELGGKSP
L
IV
FD
D
-
AD
-----
L
D
L
A
ADIAMMANFF
S
S
GQVC
TNGT
RV
FVPAKCN
A
A
F
EQKILARVERI
R
A
G
DVFDPQ
-
TNF
GPL
V
S
F
P
H
R
D
N
V
LRY
I
AK
G
KEE
G
-
AR
V
LC
G
G
--
DVLK
G
DG
L
D
N
G
A
WVA
PT
V
FTDCSDEMT
I
VR
EE
I
FGPV
M
S
I
LTYESE
D
E
V
I
RR
AND
T
D
YGL
A
A
G
I
V
T
A
DL
NR
A
H
R
V
I
HQ
L
E
A
G
IC
W
I
N
TWGESPAEM
P
V
GG
Y
K
H
SG
I
G
REN
G
VMT
L
QS
Y
TQV
K
S
I
Q
V
E
M
fig|444448.5.peg.3036
Escherichia coli O157:H7 str. EC4045 (1-483/490)
M
S
RMA
E
QQ
L
Y
I
H
G
GYTSATSG
---
RTFETI
NPA
N
GNV
L
ATVQA
A
GRE
D
V
D
R
AV
K
S
A
QQG
Q
--KI
W
AAMT
A
ME
R
SRI
L
R
R
AV
D
I
L
R
ERND
E
L
A
K
LE
TL
D
T
GK
AYSETSTV
D
I
VTGADVLE
Y
Y
AG
LIPSLE
G
---SQI
---
PLRETSFVYTR
R
E
PLGV
V
A
G
I
G
A
WN
Y
P
IQ
I
AL
WK
SA
PALAAGN
A
M
I
F
KPSE
V
TPLTAL
KL
A
E
I
YS
EAG
L
P
D
GV
F
NV
L
P
G
V
G
AET
G
QY
LT
E
HP
G
I
AK
VS
F
TG
G
VA
S
GK
K
V
MAN
S
A
A
S
SL
K
E
V
T
M
ELGGKSP
L
IV
FD
D
-
AD
-----
L
D
L
A
ADIAMMANFF
S
S
GQVC
TNGT
RV
FVPAKCN
A
A
F
EQKILARVERI
R
A
G
DVFDPQ
-
TNF
GPL
V
S
F
P
H
R
D
N
V
LRY
I
AK
G
KEE
G
-
AR
V
LC
G
G
--
DVLK
G
DG
L
D
N
G
A
WVA
PT
V
FTDCSDEMT
I
VR
EE
I
FGPV
M
S
I
LTYESE
D
E
V
I
RR
AND
T
D
YGL
A
A
G
I
V
T
A
DL
NR
A
H
R
V
I
HQ
L
E
A
G
IC
W
I
N
TWGESPAEM
P
V
GG
Y
K
H
SG
I
G
REN
G
VMT
L
QS
Y
TQV
K
S
I
Q
V
E
M
fig|444453.5.peg.4007
Escherichia coli O157:H7 str. EC4076 (1-483/490)
M
S
RMA
E
QQ
L
Y
I
H
G
GYTSATSG
---
RTFETI
NPA
N
GNV
L
ATVQA
A
GRE
D
V
D
R
AV
K
S
A
QQG
Q
--KI
W
AAMT
A
ME
R
SRI
L
R
R
AV
D
I
L
R
ERND
E
L
A
K
LE
TL
D
T
GK
AYSETSTV
D
I
VTGADVLE
Y
Y
AG
LIPSLE
G
---SQI
---
PLRETSFVYTR
R
E
PLGV
V
A
G
I
G
A
WN
Y
P
IQ
I
AL
WK
SA
PALAAGN
A
M
I
F
KPSE
V
TPLTAL
KL
A
E
I
YS
EAG
L
P
D
GV
F
NV
L
P
G
V
G
AET
G
QY
LT
E
HP
G
I
AK
VS
F
TG
G
VA
S
GK
K
V
MAN
S
A
A
S
SL
K
E
V
T
M
ELGGKSP
L
IV
FD
D
-
AD
-----
L
D
L
A
ADIAMMANFF
S
S
GQVC
TNGT
RV
FVPAKCN
A
A
F
EQKILARVERI
R
A
G
DVFDPQ
-
TNF
GPL
V
S
F
P
H
R
D
N
V
LRY
I
AK
G
KEE
G
-
AR
V
LC
G
G
--
DVLK
G
DG
L
D
N
G
A
WVA
PT
V
FTDCSDEMT
I
VR
EE
I
FGPV
M
S
I
LTYESE
D
E
V
I
RR
AND
T
D
YGL
A
A
G
I
V
T
A
DL
NR
A
H
R
V
I
HQ
L
E
A
G
IC
W
I
N
TWGESPAEM
P
V
GG
Y
K
H
SG
I
G
REN
G
VMT
L
QS
Y
TQV
K
S
I
Q
V
E
M
fig|444452.5.peg.2201
Escherichia coli O157:H7 str. EC4113 (1-483/490)
M
S
RMA
E
QQ
L
Y
I
H
G
GYTSATSG
---
RTFETI
NPA
N
GNV
L
ATVQA
A
GRE
D
V
D
R
AV
K
S
A
QQG
Q
--KI
W
AAMT
A
ME
R
SRI
L
R
R
AV
D
I
L
R
ERND
E
L
A
K
LE
TL
D
T
GK
AYSETSTV
D
I
VTGADVLE
Y
Y
AG
LIPSLE
G
---SQI
---
PLRETSFVYTR
R
E
PLGV
V
A
G
I
G
A
WN
Y
P
IQ
I
AL
WK
SA
PALAAGN
A
M
I
F
KPSE
V
TPLTAL
KL
A
E
I
YS
EAG
L
P
D
GV
F
NV
L
P
G
V
G
AET
G
QY
LT
E
HP
G
I
AK
VS
F
TG
G
VA
S
GK
K
V
MAN
S
A
A
S
SL
K
E
V
T
M
ELGGKSP
L
IV
FD
D
-
AD
-----
L
D
L
A
ADIAMMANFF
S
S
GQVC
TNGT
RV
FVPAKCN
A
A
F
EQKILARVERI
R
A
G
DVFDPQ
-
TNF
GPL
V
S
F
P
H
R
D
N
V
LRY
I
AK
G
KEE
G
-
AR
V
LC
G
G
--
DVLK
G
DG
L
D
N
G
A
WVA
PT
V
FTDCSDEMT
I
VR
EE
I
FGPV
M
S
I
LTYESE
D
E
V
I
RR
AND
T
D
YGL
A
A
G
I
V
T
A
DL
NR
A
H
R
V
I
HQ
L
E
A
G
IC
W
I
N
TWGESPAEM
P
V
GG
Y
K
H
SG
I
G
REN
G
VMT
L
QS
Y
TQV
K
S
I
Q
V
E
M
fig|444450.8.peg.498
Escherichia coli O157:H7 str. EC4115 (1-483/490)
M
S
RMA
E
QQ
L
Y
I
H
G
GYTSATSG
---
RTFETI
NPA
N
GNV
L
ATVQA
A
GRE
D
V
D
R
AV
K
S
A
QQG
Q
--KI
W
AAMT
A
ME
R
SRI
L
R
R
AV
D
I
L
R
ERND
E
L
A
K
LE
TL
D
T
GK
AYSETSTV
D
I
VTGADVLE
Y
Y
AG
LIPSLE
G
---SQI
---
PLRETSFVYTR
R
E
PLGV
V
A
G
I
G
A
WN
Y
P
IQ
I
AL
WK
SA
PALAAGN
A
M
I
F
KPSE
V
TPLTAL
KL
A
E
I
YS
EAG
L
P
D
GV
F
NV
L
P
G
V
G
AET
G
QY
LT
E
HP
G
I
AK
VS
F
TG
G
VA
S
GK
K
V
MAN
S
A
A
S
SL
K
E
V
T
M
ELGGKSP
L
IV
FD
D
-
AD
-----
L
D
L
A
ADIAMMANFF
S
S
GQVC
TNGT
RV
FVPAKCN
A
A
F
EQKILARVERI
R
A
G
DVFDPQ
-
TNF
GPL
V
S
F
P
H
R
D
N
V
LRY
I
AK
G
KEE
G
-
AR
V
LC
G
G
--
DVLK
G
DG
L
D
N
G
A
WVA
PT
V
FTDCSDEMT
I
VR
EE
I
FGPV
M
S
I
LTYESE
D
E
V
I
RR
AND
T
D
YGL
A
A
G
I
V
T
A
DL
NR
A
H
R
V
I
HQ
L
E
A
G
IC
W
I
N
TWGESPAEM
P
V
GG
Y
K
H
SG
I
G
REN
G
VMT
L
QS
Y
TQV
K
S
I
Q
V
E
M
fig|444451.5.peg.2966
Escherichia coli O157:H7 str. EC4196 (1-483/490)
M
S
RMA
E
QQ
L
Y
I
H
G
GYTSATSG
---
RTFETI
NPA
N
GNV
L
ATVQA
A
GRE
D
V
D
R
AV
K
S
A
QQG
Q
--KI
W
AAMT
A
ME
R
SRI
L
R
R
AV
D
I
L
R
ERND
E
L
A
K
LE
TL
D
T
GK
AYSETSTV
D
I
VTGADVLE
Y
Y
AG
LIPSLE
G
---SQI
---
PLRETSFVYTR
R
E
PLGV
V
A
G
I
G
A
WN
Y
P
IQ
I
AL
WK
SA
PALAAGN
A
M
I
F
KPSE
V
TPLTAL
KL
A
E
I
YS
EAG
L
P
D
GV
F
NV
L
P
G
V
G
AET
G
QY
LT
E
HP
G
I
AK
VS
F
TG
G
VA
S
GK
K
V
MAN
S
A
A
S
SL
K
E
V
T
M
ELGGKSP
L
IV
FD
D
-
AD
-----
L
D
L
A
ADIAMMANFF
S
S
GQVC
TNGT
RV
FVPAKCN
A
A
F
EQKILARVERI
R
A
G
DVFDPQ
-
TNF
GPL
V
S
F
P
H
R
D
N
V
LRY
I
AK
G
KEE
G
-
AR
V
LC
G
G
--
DVLK
G
DG
L
D
N
G
A
WVA
PT
V
FTDCSDEMT
I
VR
EE
I
FGPV
M
S
I
LTYESE
D
E
V
I
RR
AND
T
D
YGL
A
A
G
I
V
T
A
DL
NR
A
H
R
V
I
HQ
L
E
A
G
IC
W
I
N
TWGESPAEM
P
V
GG
Y
K
H
SG
I
G
REN
G
VMT
L
QS
Y
TQV
K
S
I
Q
V
E
M
fig|444447.5.peg.3206
Escherichia coli O157:H7 str. EC4206 (1-483/490)
M
S
RMA
E
QQ
L
Y
I
H
G
GYTSATSG
---
RTFETI
NPA
N
GNV
L
ATVQA
A
GRE
D
V
D
R
AV
K
S
A
QQG
Q
--KI
W
AAMT
A
ME
R
SRI
L
R
R
AV
D
I
L
R
ERND
E
L
A
K
LE
TL
D
T
GK
AYSETSTV
D
I
VTGADVLE
Y
Y
AG
LIPSLE
G
---SQI
---
PLRETSFVYTR
R
E
PLGV
V
A
G
I
G
A
WN
Y
P
IQ
I
AL
WK
SA
PALAAGN
A
M
I
F
KPSE
V
TPLTAL
KL
A
E
I
YS
EAG
L
P
D
GV
F
NV
L
P
G
V
G
AET
G
QY
LT
E
HP
G
I
AK
VS
F
TG
G
VA
S
GK
K
V
MAN
S
A
A
S
SL
K
E
V
T
M
ELGGKSP
L
IV
FD
D
-
AD
-----
L
D
L
A
ADIAMMANFF
S
S
GQVC
TNGT
RV
FVPAKCN
A
A
F
EQKILARVERI
R
A
G
DVFDPQ
-
TNF
GPL
V
S
F
P
H
R
D
N
V
LRY
I
AK
G
KEE
G
-
AR
V
LC
G
G
--
DVLK
G
DG
L
D
N
G
A
WVA
PT
V
FTDCSDEMT
I
VR
EE
I
FGPV
M
S
I
LTYESE
D
E
V
I
RR
AND
T
D
YGL
A
A
G
I
V
T
A
DL
NR
A
H
R
V
I
HQ
L
E
A
G
IC
W
I
N
TWGESPAEM
P
V
GG
Y
K
H
SG
I
G
REN
G
VMT
L
QS
Y
TQV
K
S
I
Q
V
E
M
fig|478004.5.peg.2634
Escherichia coli O157:H7 str. EC4401 (1-483/490)
M
S
RMA
E
QQ
L
Y
I
H
G
GYTSATSG
---
RTFETI
NPA
N
GNV
L
ATVQA
A
GRE
D
V
D
R
AV
K
S
A
QQG
Q
--KI
W
AAMT
A
ME
R
SRI
L
R
R
AV
D
I
L
R
ERND
E
L
A
K
LE
TL
D
T
GK
AYSETSTV
D
I
VTGADVLE
Y
Y
AG
LIPSLE
G
---SQI
---
PLRETSFVYTR
R
E
PLGV
V
A
G
I
G
A
WN
Y
P
IQ
I
AL
WK
SA
PALAAGN
A
M
I
F
KPSE
V
TPLTAL
KL
A
E
I
YS
EAG
L
P
D
GV
F
NV
L
P
G
V
G
AET
G
QY
LT
E
HP
G
I
AK
VS
F
TG
G
VA
S
GK
K
V
MAN
S
A
A
S
SL
K
E
V
T
M
ELGGKSP
L
IV
FD
D
-
AD
-----
L
D
L
A
ADIAMMANFF
S
S
GQVC
TNGT
RV
FVPAKCN
A
A
F
EQKILARVERI
R
A
G
DVFDPQ
-
TNF
GPL
V
S
F
P
H
R
D
N
V
LRY
I
AK
G
KEE
G
-
AR
V
LC
G
G
--
DVLK
G
DG
L
D
N
G
A
WVA
PT
V
FTDCSDEMT
I
VR
EE
I
FGPV
M
S
I
LTYESE
D
E
V
I
RR
AND
T
D
YGL
A
A
G
I
V
T
A
DL
NR
A
H
R
V
I
HQ
L
E
A
G
IC
W
I
N
TWGESPAEM
P
V
GG
Y
K
H
SG
I
G
REN
G
VMT
L
QS
Y
TQV
K
S
I
Q
V
E
M
fig|478006.5.peg.2442
Escherichia coli O157:H7 str. EC4501 (1-483/490)
M
S
RMA
E
QQ
L
Y
I
H
G
GYTSATSG
---
RTFETI
NPA
N
GNV
L
ATVQA
A
GRE
D
V
D
R
AV
K
S
A
QQG
Q
--KI
W
AAMT
A
ME
R
SRI
L
R
R
AV
D
I
L
R
ERND
E
L
A
K
LE
TL
D
T
GK
AYSETSTV
D
I
VTGADVLE
Y
Y
AG
LIPSLE
G
---SQI
---
PLRETSFVYTR
R
E
PLGV
V
A
G
I
G
A
WN
Y
P
IQ
I
AL
WK
SA
PALAAGN
A
M
I
F
KPSE
V
TPLTAL
KL
A
E
I
YS
EAG
L
P
D
GV
F
NV
L
P
G
V
G
AET
G
QY
LT
E
HP
G
I
AK
VS
F
TG
G
VA
S
GK
K
V
MAN
S
A
A
S
SL
K
E
V
T
M
ELGGKSP
L
IV
FD
D
-
AD
-----
L
D
L
A
ADIAMMANFF
S
S
GQVC
TNGT
RV
FVPAKCN
A
A
F
EQKILARVERI
R
A
G
DVFDPQ
-
TNF
GPL
V
S
F
P
H
R
D
N
V
LRY
I
AK
G
KEE
G
-
AR
V
LC
G
G
--
DVLK
G
DG
L
D
N
G
A
WVA
PT
V
FTDCSDEMT
I
VR
EE
I
FGPV
M
S
I
LTYESE
D
E
V
I
RR
AND
T
D
YGL
A
A
G
I
V
T
A
DL
NR
A
H
R
V
I
HQ
L
E
A
G
IC
W
I
N
TWGESPAEM
P
V
GG
Y
K
H
SG
I
G
REN
G
VMT
L
QS
Y
TQV
K
S
I
Q
V
E
M
fig|478007.5.peg.2475
Escherichia coli O157:H7 str. EC508 (1-483/490)
M
S
RMA
E
QQ
L
Y
I
H
G
GYTSATSG
---
RTFETI
NPA
N
GNV
L
ATVQA
A
GRE
D
V
D
R
AV
K
S
A
QQG
Q
--KI
W
AAMT
A
ME
R
SRI
L
R
R
AV
D
I
L
R
ERND
E
L
A
K
LE
TL
D
T
GK
AYSETSTV
D
I
VTGADVLE
Y
Y
AG
LIPSLE
G
---SQI
---
PLRETSFVYTR
R
E
PLGV
V
A
G
I
G
A
WN
Y
P
IQ
I
AL
WK
SA
PALAAGN
A
M
I
F
KPSE
V
TPLTAL
KL
A
E
I
YS
EAG
L
P
D
GV
F
NV
L
P
G
V
G
AET
G
QY
LT
E
HP
G
I
AK
VS
F
TG
G
VA
S
GK
K
V
MAN
S
A
A
S
SL
K
E
V
T
M
ELGGKSP
L
IV
FD
D
-
AD
-----
L
D
L
A
ADIAMMANFF
S
S
GQVC
TNGT
RV
FVPAKCN
A
A
F
EQKILARVERI
R
A
G
DVFDPQ
-
TNF
GPL
V
S
F
P
H
R
D
N
V
LRY
I
AK
G
KEE
G
-
AR
V
LC
G
G
--
DVLK
G
DG
L
D
N
G
A
WVA
PT
V
FTDCSDEMT
I
VR
EE
I
FGPV
M
S
I
LTYESE
D
E
V
I
RR
AND
T
D
YGL
A
A
G
I
V
T
A
DL
NR
A
H
R
V
I
HQ
L
E
A
G
IC
W
I
N
TWGESPAEM
P
V
GG
Y
K
H
SG
I
G
REN
G
VMT
L
QS
Y
TQV
K
S
I
Q
V
E
M
fig|478008.5.peg.3776
Escherichia coli O157:H7 str. EC869 (1-483/490)
M
S
RMA
E
QQ
L
Y
I
H
G
GYTSATSG
---
RTFETI
NPA
N
GNV
L
ATVQA
A
GRE
D
V
D
R
AV
K
S
A
QQG
Q
--KI
W
AAMT
A
ME
R
SRI
L
R
R
AV
D
I
L
R
ERND
E
L
A
K
LE
TL
D
T
GK
AYSETSTV
D
I
VTGADVLE
Y
Y
AG
LIPSLE
G
---SQI
---
PLRETSFVYTR
R
E
PLGV
V
A
G
I
G
A
WN
Y
P
IQ
I
AL
WK
SA
PALAAGN
A
M
I
F
KPSE
V
TPLTAL
KL
A
E
I
YS
EAG
L
P
D
GV
F
NV
L
P
G
V
G
AET
G
QY
LT
E
HP
G
I
AK
VS
F
TG
G
VA
S
GK
K
V
MAN
S
A
A
S
SL
K
E
V
T
M
ELGGKSP
L
IV
FD
D
-
AD
-----
L
D
L
A
ADIAMMANFF
S
S
GQVC
TNGT
RV
FVPAKCN
A
A
F
EQKILARVERI
R
A
G
DVFDPQ
-
TNF
GPL
V
S
F
P
H
R
D
N
V
LRY
I
AK
G
KEE
G
-
AR
V
LC
G
G
--
DVLK
G
DG
L
D
N
G
A
WVA
PT
V
FTDCSDEMT
I
VR
EE
I
FGPV
M
S
I
LTYESE
D
E
V
I
RR
AND
T
D
YGL
A
A
G
I
V
T
A
DL
NR
A
H
R
V
I
HQ
L
E
A
G
IC
W
I
N
TWGESPAEM
P
V
GG
Y
K
H
SG
I
G
REN
G
VMT
L
QS
Y
TQV
K
S
I
Q
V
E
M
fig|637388.3.peg.837
Escherichia coli O157:H7 str. FRIK2000 (1-483/490)
M
S
RMA
E
QQ
L
Y
I
H
G
GYTSATSG
---
RTFETI
NPA
N
GNV
L
ATVQA
A
GRE
D
V
D
R
AV
K
S
A
QQG
Q
--KI
W
AAMT
A
ME
R
SRI
L
R
R
AV
D
I
L
R
ERND
E
L
A
K
LE
TL
D
T
GK
AYSETSTV
D
I
VTGADVLE
Y
Y
AG
LIPSLE
G
---SQI
---
PLRETSFVYTR
R
E
PLGV
V
A
G
I
G
A
WN
Y
P
IQ
I
AL
WK
SA
PALAAGN
A
M
I
F
KPSE
V
TPLTAL
KL
A
E
I
YS
EAG
L
P
D
GV
F
NV
L
P
G
V
G
AET
G
QY
LT
E
HP
G
I
AK
VS
F
TG
G
VA
S
GK
K
V
MAN
S
A
A
S
SL
K
E
V
T
M
ELGGKSP
L
IV
FD
D
-
AD
-----
L
D
L
A
ADIAMMANFF
S
S
GQVC
TNGT
RV
FVPAKCN
A
A
F
EQKILARVERI
R
A
G
DVFDPQ
-
TNF
GPL
V
S
F
P
H
R
D
N
V
LRY
I
AK
G
KEE
G
-
AR
V
LC
G
G
--
DVLK
G
DG
L
D
N
G
A
WVA
PT
V
FTDCSDEMT
I
VR
EE
I
FGPV
M
S
I
LTYESE
D
E
V
I
RR
AND
T
D
YGL
A
A
G
I
V
T
A
DL
NR
A
H
R
V
I
HQ
L
E
A
G
IC
W
I
N
TWGESPAEM
P
V
GG
Y
K
H
SG
I
G
REN
G
VMT
L
QS
Y
TQV
K
S
I
Q
V
E
M
fig|570506.3.peg.1845
Escherichia coli O157:H7 str. FRIK966 (1-483/490)
M
S
RMA
E
QQ
L
Y
I
H
G
GYTSATSG
---
RTFETI
NPA
N
GNV
L
ATVQA
A
GRE
D
V
D
R
AV
K
S
A
QQG
Q
--KI
W
AAMT
A
ME
R
SRI
L
R
R
AV
D
I
L
R
ERND
E
L
A
K
LE
TL
D
T
GK
AYSETSTV
D
I
VTGADVLE
Y
Y
AG
LIPSLE
G
---SQI
---
PLRETSFVYTR
R
E
PLGV
V
A
G
I
G
A
WN
Y
P
IQ
I
AL
WK
SA
PALAAGN
A
M
I
F
KPSE
V
TPLTAL
KL
A
E
I
YS
EAG
L
P
D
GV
F
NV
L
P
G
V
G
AET
G
QY
LT
E
HP
G
I
AK
VS
F
TG
G
VA
S
GK
K
V
MAN
S
A
A
S
SL
K
E
V
T
M
ELGGKSP
L
IV
FD
D
-
AD
-----
L
D
L
A
ADIAMMANFF
S
S
GQVC
TNGT
RV
FVPAKCN
A
A
F
EQKILARVERI
R
A
G
DVFDPQ
-
TNF
GPL
V
S
F
P
H
R
D
N
V
LRY
I
AK
G
KEE
G
-
AR
V
LC
G
G
--
DVLK
G
DG
L
D
N
G
A
WVA
PT
V
FTDCSDEMT
I
VR
EE
I
FGPV
M
S
I
LTYESE
D
E
V
I
RR
AND
T
D
YGL
A
A
G
I
V
T
A
DL
NR
A
H
R
V
I
HQ
L
E
A
G
IC
W
I
N
TWGESPAEM
P
V
GG
Y
K
H
SG
I
G
REN
G
VMT
L
QS
Y
TQV
K
S
I
Q
V
E
M
fig|544404.4.peg.363
Escherichia coli O157:H7 str. TW14359 (1-483/490)
M
S
RMA
E
QQ
L
Y
I
H
G
GYTSATSG
---
RTFETI
NPA
N
GNV
L
ATVQA
A
GRE
D
V
D
R
AV
K
S
A
QQG
Q
--KI
W
AAMT
A
ME
R
SRI
L
R
R
AV
D
I
L
R
ERND
E
L
A
K
LE
TL
D
T
GK
AYSETSTV
D
I
VTGADVLE
Y
Y
AG
LIPSLE
G
---SQI
---
PLRETSFVYTR
R
E
PLGV
V
A
G
I
G
A
WN
Y
P
IQ
I
AL
WK
SA
PALAAGN
A
M
I
F
KPSE
V
TPLTAL
KL
A
E
I
YS
EAG
L
P
D
GV
F
NV
L
P
G
V
G
AET
G
QY
LT
E
HP
G
I
AK
VS
F
TG
G
VA
S
GK
K
V
MAN
S
A
A
S
SL
K
E
V
T
M
ELGGKSP
L
IV
FD
D
-
AD
-----
L
D
L
A
ADIAMMANFF
S
S
GQVC
TNGT
RV
FVPAKCN
A
A
F
EQKILARVERI
R
A
G
DVFDPQ
-
TNF
GPL
V
S
F
P
H
R
D
N
V
LRY
I
AK
G
KEE
G
-
AR
V
LC
G
G
--
DVLK
G
DG
L
D
N
G
A
WVA
PT
V
FTDCSDEMT
I
VR
EE
I
FGPV
M
S
I
LTYESE
D
E
V
I
RR
AND
T
D
YGL
A
A
G
I
V
T
A
DL
NR
A
H
R
V
I
HQ
L
E
A
G
IC
W
I
N
TWGESPAEM
P
V
GG
Y
K
H
SG
I
G
REN
G
VMT
L
QS
Y
TQV
K
S
I
Q
V
E
M
fig|502346.5.peg.912
Escherichia coli O157:H7 str. TW14588 (1-483/490)
M
S
RMA
E
QQ
L
Y
I
H
G
GYTSATSG
---
RTFETI
NPA
N
GNV
L
ATVQA
A
GRE
D
V
D
R
AV
K
S
A
QQG
Q
--KI
W
AAMT
A
ME
R
SRI
L
R
R
AV
D
I
L
R
ERND
E
L
A
K
LE
TL
D
T
GK
AYSETSTV
D
I
VTGADVLE
Y
Y
AG
LIPSLE
G
---SQI
---
PLRETSFVYTR
R
E
PLGV
V
A
G
I
G
A
WN
Y
P
IQ
I
AL
WK
SA
PALAAGN
A
M
I
F
KPSE
V
TPLTAL
KL
A
E
I
YS
EAG
L
P
D
GV
F
NV
L
P
G
V
G
AET
G
QY
LT
E
HP
G
I
AK
VS
F
TG
G
VA
S
GK
K
V
MAN
S
A
A
S
SL
K
E
V
T
M
ELGGKSP
L
IV
FD
D
-
AD
-----
L
D
L
A
ADIAMMANFF
S
S
GQVC
TNGT
RV
FVPAKCN
A
A
F
EQKILARVERI
R
A
G
DVFDPQ
-
TNF
GPL
V
S
F
P
H
R
D
N
V
LRY
I
AK
G
KEE
G
-
AR
V
LC
G
G
--
DVLK
G
DG
L
D
N
G
A
WVA
PT
V
FTDCSDEMT
I
VR
EE
I
FGPV
M
S
I
LTYESE
D
E
V
I
RR
AND
T
D
YGL
A
A
G
I
V
T
A
DL
NR
A
H
R
V
I
HQ
L
E
A
G
IC
W
I
N
TWGESPAEM
P
V
GG
Y
K
H
SG
I
G
REN
G
VMT
L
QS
Y
TQV
K
S
I
Q
V
E
M
fig|83334.1.peg.438
Escherichia coli O157:H7 (1-483/490)
M
S
RMA
E
QQ
L
Y
I
H
G
GYTSATSG
---
RTFETI
NPA
N
GNV
L
ATVQA
A
GRE
D
V
D
R
AV
K
S
A
QQG
Q
--KI
W
AAMT
A
ME
R
SRI
L
R
R
AV
D
I
L
R
ERND
E
L
A
K
LE
TL
D
T
GK
AYSETSTV
D
I
VTGADVLE
Y
Y
AG
LIPSLE
G
---SQI
---
PLRETSFVYTR
R
E
PLGV
V
A
G
I
G
A
WN
Y
P
IQ
I
AL
WK
SA
PALAAGN
A
M
I
F
KPSE
V
TPLTAL
KL
A
E
I
YS
EAG
L
P
D
GV
F
NV
L
P
G
V
G
AET
G
QY
LT
E
HP
G
I
AK
VS
F
TG
G
VA
S
GK
K
V
MAN
S
A
A
S
SL
K
E
V
T
M
ELGGKSP
L
IV
FD
D
-
AD
-----
L
D
L
A
ADIAMMANFF
S
S
GQVC
TNGT
RV
FVPAKCN
A
A
F
EQKILARVERI
R
A
G
DVFDPQ
-
TNF
GPL
V
S
F
P
H
R
D
N
V
LRY
I
AK
G
KEE
G
-
AR
V
LC
G
G
--
DVLK
G
Y
G
L
D
N
G
A
WVA
PT
V
FTDCSDEMT
I
VR
EE
I
FGPV
M
S
I
LTYESE
D
E
V
I
RR
AND
T
D
YGL
A
A
G
I
V
T
A
DL
NR
A
H
R
V
I
HQ
L
E
A
G
IC
W
I
N
TWGESPAEM
P
V
GG
Y
K
H
SG
I
G
REN
G
VMT
L
QS
Y
TQV
K
S
I
Q
V
E
M
fig|386585.9.peg.450
Escherichia coli O157:H7 str. Sakai (1-483/490)
M
S
RMA
E
QQ
L
Y
I
H
G
GYTSATSG
---
RTFETI
NPA
N
GNV
L
ATVQA
A
GRE
D
V
D
R
AV
K
S
A
QQG
Q
--KI
W
AAMT
A
ME
R
SRI
L
R
R
AV
D
I
L
R
ERND
E
L
A
K
LE
TL
D
T
GK
AYSETSTV
D
I
VTGADVLE
Y
Y
AG
LIPSLE
G
---SQI
---
PLRETSFVYTR
R
E
PLGV
V
A
G
I
G
A
WN
Y
P
IQ
I
AL
WK
SA
PALAAGN
A
M
I
F
KPSE
V
TPLTAL
KL
A
E
I
YS
EAG
L
P
D
GV
F
NV
L
P
G
V
G
AET
G
QY
LT
E
HP
G
I
AK
VS
F
TG
G
VA
S
GK
K
V
MAN
S
A
A
S
SL
K
E
V
T
M
ELGGKSP
L
IV
FD
D
-
AD
-----
L
D
L
A
ADIAMMANFF
S
S
GQVC
TNGT
RV
FVPAKCN
A
A
F
EQKILARVERI
R
A
G
DVFDPQ
-
TNF
GPL
V
S
F
P
H
R
D
N
V
LRY
I
AK
G
KEE
G
-
AR
V
LC
G
G
--
DVLK
G
Y
G
L
D
N
G
A
WVA
PT
V
FTDCSDEMT
I
VR
EE
I
FGPV
M
S
I
LTYESE
D
E
V
I
RR
AND
T
D
YGL
A
A
G
I
V
T
A
DL
NR
A
H
R
V
I
HQ
L
E
A
G
IC
W
I
N
TWGESPAEM
P
V
GG
Y
K
H
SG
I
G
REN
G
VMT
L
QS
Y
TQV
K
S
I
Q
V
E
M
fig|1040638.4.peg.5460
Escherichia coli O104:H4 str. LB226692 (1-483/490)
M
S
RMA
E
QQ
L
Y
I
H
G
GYTSATSG
---
RTFETI
NPA
N
GNV
L
ATVQA
A
GRE
D
V
D
R
AV
K
S
A
QQG
Q
--KI
W
AAMT
A
ME
R
SRI
L
R
R
AV
D
I
L
R
ERND
E
L
A
K
LE
TL
D
T
GK
AYSETSTV
D
I
VTGADVLE
Y
Y
AG
LIPALE
G
---SQI
---
PLRETSFVYTR
R
E
PLGV
V
A
G
I
G
A
WN
Y
P
IQ
I
AL
WK
SA
PALAAGN
A
M
I
F
KPSE
V
TPLTAL
KL
A
E
I
YS
EAG
L
P
D
GV
F
NV
L
P
G
V
G
AET
G
QY
LT
E
HP
G
I
AK
VS
F
TG
G
VA
S
GK
K
V
MAN
S
A
A
S
SL
K
E
V
T
M
ELGGKSP
L
IV
FD
D
-
AD
-----
L
D
L
A
ADIAMMANFF
S
S
GQVC
TNGT
RV
FVPAKCK
A
A
F
EQKILARVERI
R
A
G
DVFDPQ
-
TNF
GPL
V
S
F
P
H
R
D
N
V
LRY
I
AK
G
KEE
G
-
AR
V
LC
G
G
--
DVLK
G
DG
F
D
N
G
A
WVA
PT
V
FTDCSDDMT
I
VR
EE
I
FGPV
M
S
L
LTYESE
D
E
V
I
RR
AND
T
D
YGL
A
A
G
I
V
T
A
DL
NR
A
H
R
V
I
HQ
L
E
A
G
IC
W
I
N
TWGESPAEM
P
V
GG
Y
K
H
SG
I
G
REN
G
VMT
L
QS
Y
TQV
K
S
I
Q
V
E
M
fig|585055.6.peg.320
Escherichia coli 55989 (1-483/490)
M
S
RMA
E
QQ
L
Y
I
H
G
GYTSATSG
---
RTFETI
NPA
N
GNV
L
ATVQA
A
GRE
D
V
D
R
AV
K
S
A
QQG
Q
--KI
W
AAMT
A
ME
R
SRI
L
R
R
AV
D
I
L
R
ERND
E
L
A
K
LE
TL
D
T
GK
AYSETSTV
D
I
VTGADVLE
Y
Y
AG
LIPALE
G
---SQI
---
PLRETSFVYTR
R
E
PLGV
V
A
G
I
G
A
WN
Y
P
IQ
I
AL
WK
SA
PALAAGN
A
M
I
F
KPSE
V
TPLTAL
KL
A
E
I
YS
EAG
L
P
D
GV
F
NV
L
P
G
V
G
AET
G
QY
LT
E
HP
G
I
AK
VS
F
TG
G
VA
S
GK
K
V
MAN
S
A
A
S
SL
K
E
V
T
M
ELGGKSP
L
IV
FD
D
-
AD
-----
L
D
L
A
ADIAMMANFF
S
S
GQVC
TNGT
RV
FVPAKCK
A
A
F
EQKILARVERI
R
A
G
DVFDPQ
-
TNF
GPL
V
S
F
P
H
R
D
N
V
LRY
I
AK
G
KEE
G
-
AR
V
LC
G
G
--
DVLK
G
DG
F
D
N
G
A
WVA
PT
V
FTDCSDDMT
I
VR
EE
I
FGPV
M
S
L
LTYESE
D
E
V
I
RR
AND
T
D
YGL
A
A
G
I
V
T
A
DL
NR
A
H
R
V
I
HQ
L
E
A
G
IC
W
I
N
TWGESPAEM
P
V
GG
Y
K
H
SG
I
G
REN
G
VMT
L
QS
Y
TQV
K
S
I
Q
V
E
M
fig|585055.8.peg.321
Escherichia coli 55989 (1-483/490)
M
S
RMA
E
QQ
L
Y
I
H
G
GYTSATSG
---
RTFETI
NPA
N
GNV
L
ATVQA
A
GRE
D
V
D
R
AV
K
S
A
QQG
Q
--KI
W
AAMT
A
ME
R
SRI
L
R
R
AV
D
I
L
R
ERND
E
L
A
K
LE
TL
D
T
GK
AYSETSTV
D
I
VTGADVLE
Y
Y
AG
LIPALE
G
---SQI
---
PLRETSFVYTR
R
E
PLGV
V
A
G
I
G
A
WN
Y
P
IQ
I
AL
WK
SA
PALAAGN
A
M
I
F
KPSE
V
TPLTAL
KL
A
E
I
YS
EAG
L
P
D
GV
F
NV
L
P
G
V
G
AET
G
QY
LT
E
HP
G
I
AK
VS
F
TG
G
VA
S
GK
K
V
MAN
S
A
A
S
SL
K
E
V
T
M
ELGGKSP
L
IV
FD
D
-
AD
-----
L
D
L
A
ADIAMMANFF
S
S
GQVC
TNGT
RV
FVPAKCK
A
A
F
EQKILARVERI
R
A
G
DVFDPQ
-
TNF
GPL
V
S
F
P
H
R
D
N
V
LRY
I
AK
G
KEE
G
-
AR
V
LC
G
G
--
DVLK
G
DG
F
D
N
G
A
WVA
PT
V
FTDCSDDMT
I
VR
EE
I
FGPV
M
S
L
LTYESE
D
E
V
I
RR
AND
T
D
YGL
A
A
G
I
V
T
A
DL
NR
A
H
R
V
I
HQ
L
E
A
G
IC
W
I
N
TWGESPAEM
P
V
GG
Y
K
H
SG
I
G
REN
G
VMT
L
QS
Y
TQV
K
S
I
Q
V
E
M
fig|656408.3.peg.237
Escherichia coli H591 (1-483/490)
M
S
RMA
E
QQ
L
Y
I
H
G
GYTSATSG
---
RTFETI
NPA
N
GNV
L
ATVQA
A
GRE
D
V
D
R
AV
K
S
A
QQG
Q
--KI
W
AAMT
A
ME
R
SRI
L
R
R
AV
D
I
L
R
ERND
E
L
A
K
LE
TL
D
T
GK
AYSETSTV
D
I
VTGADVLE
Y
Y
AG
LIPALE
G
---SQI
---
PLRETSFVYTR
R
E
PLGV
V
A
G
I
G
A
WN
Y
P
IQ
I
AL
WK
SA
PALAAGN
A
M
I
F
KPSE
V
TPLTAL
KL
A
E
I
YS
EAG
L
P
D
GV
F
NV
L
P
G
V
G
AET
G
QY
LT
E
HP
G
I
AK
VS
F
TG
G
VA
S
GK
K
V
MAN
S
A
A
S
SL
K
E
V
T
M
ELGGKSP
L
IV
FD
D
-
AD
-----
L
D
L
A
ADIAMMANFF
S
S
GQVC
TNGT
RV
FVPAKCK
A
A
F
EQKILARVERI
R
A
G
DVFDPQ
-
TNF
GPL
V
S
F
P
H
R
D
N
V
LRY
I
AK
G
KEE
G
-
AR
V
LC
G
G
--
DVLK
G
DG
F
D
N
G
A
WVA
PT
V
FTDCSDDMT
I
VR
EE
I
FGPV
M
S
L
LTYESE
D
E
V
I
RR
AND
T
D
YGL
A
A
G
I
V
T
A
DL
NR
A
H
R
V
I
HQ
L
E
A
G
IC
W
I
N
TWGESPAEM
P
V
GG
Y
K
H
SG
I
G
REN
G
VMT
L
QS
Y
TQV
K
S
I
Q
V
E
M
fig|595495.4.peg.570
Escherichia coli KO11 (1-483/490)
M
S
RMA
E
QQ
L
Y
I
H
G
GYTSATSG
---
RTFETI
NPA
N
GNV
L
ATVQA
A
GRE
D
V
D
R
AV
K
S
A
QQG
Q
--KI
W
AAMT
A
ME
R
SRI
L
R
R
AV
D
I
L
R
ERND
E
L
A
K
LE
TL
D
T
GK
AYSETSTV
D
I
VTGADVLE
Y
Y
AG
LIPALE
G
---SQI
---
PLRETSFVYTR
R
E
PLGV
V
A
G
I
G
A
WN
Y
P
IQ
I
AL
WK
SA
PALAAGN
A
M
I
F
KPSE
V
TPLTAL
KL
A
E
I
YS
EAG
L
P
D
GV
F
NV
L
P
G
V
G
AET
G
QY
LT
E
HP
G
I
AK
VS
F
TG
G
VA
S
GK
K
V
MAN
S
A
A
S
SL
K
E
V
T
M
ELGGKSP
L
IV
FD
D
-
AD
-----
L
D
L
A
ADIAMMANFF
S
S
GQVC
TNGT
RV
FVPAKCK
A
A
F
EQKILARVERI
R
A
G
DVFDPQ
-
TNF
GPL
V
S
F
P
H
R
D
N
V
LRY
I
AK
G
KEE
G
-
AR
V
LC
G
G
--
DVLK
G
DG
F
D
N
G
A
WVA
PT
V
FTDCSDDMT
I
VR
EE
I
FGPV
M
S
L
LTYESE
D
E
V
I
RR
AND
T
D
YGL
A
A
G
I
V
T
A
DL
NR
A
H
R
V
I
HQ
L
E
A
G
IC
W
I
N
TWGESPAEM
P
V
GG
Y
K
H
SG
I
G
REN
G
VMT
L
QS
Y
TQV
K
S
I
Q
V
E
M
fig|679207.4.peg.2168
Escherichia coli MS 107-1 (1-483/490)
M
S
RMA
E
QQ
L
Y
I
H
G
GYTSATSG
---
RTFETI
NPA
N
GNV
L
ATVQA
A
GRE
D
V
D
R
AV
K
S
A
QQG
Q
--KI
W
AAMT
A
ME
R
SRI
L
R
R
AV
D
I
L
R
ERND
E
L
A
K
LE
TL
D
T
GK
AYSETSTV
D
I
VTGADVLE
Y
Y
AG
LIPALE
G
---SQI
---
PLRETSFVYTR
R
E
PLGV
V
A
G
I
G
A
WN
Y
P
IQ
I
AL
WK
SA
PALAAGN
A
M
I
F
KPSE
V
TPLTAL
KL
A
E
I
YS
EAG
L
P
D
GV
F
NV
L
P
G
V
G
AET
G
QY
LT
E
HP
G
I
AK
VS
F
TG
G
VA
S
GK
K
V
MAN
S
A
A
S
SL
K
E
V
T
M
ELGGKSP
L
IV
FD
D
-
AD
-----
L
D
L
A
ADIAMMANFF
S
S
GQVC
TNGT
RV
FVPAKCK
A
A
F
EQKILARVERI
R
A
G
DVFDPQ
-
TNF
GPL
V
S
F
P
H
R
D
N
V
LRY
I
AK
G
KEE
G
-
AR
V
LC
G
G
--
DVLK
G
DG
F
D
N
G
A
WVA
PT
V
FTDCSDDMT
I
VR
EE
I
FGPV
M
S
L
LTYESE
D
E
V
I
RR
AND
T
D
YGL
A
A
G
I
V
T
A
DL
NR
A
H
R
V
I
HQ
L
E
A
G
IC
W
I
N
TWGESPAEM
P
V
GG
Y
K
H
SG
I
G
REN
G
VMT
L
QS
Y
TQV
K
S
I
Q
V
E
M
fig|679206.4.peg.248
Escherichia coli MS 119-7 (1-483/490)
M
S
RMA
E
QQ
L
Y
I
H
G
GYTSATSG
---
RTFETI
NPA
N
GNV
L
ATVQA
A
GRE
D
V
D
R
AV
K
S
A
QQG
Q
--KI
W
AAMT
A
ME
R
SRI
L
R
R
AV
D
I
L
R
ERND
E
L
A
K
LE
TL
D
T
GK
AYSETSTV
D
I
VTGADVLE
Y
Y
AG
LIPALE
G
---SQI
---
PLRETSFVYTR
R
E
PLGV
V
A
G
I
G
A
WN
Y
P
IQ
I
AL
WK
SA
PALAAGN
A
M
I
F
KPSE
V
TPLTAL
KL
A
E
I
YS
EAG
L
P
D
GV
F
NV
L
P
G
V
G
AET
G
QY
LT
E
HP
G
I
AK
VS
F
TG
G
VA
S
GK
K
V
MAN
S
A
A
S
SL
K
E
V
T
M
ELGGKSP
L
IV
FD
D
-
AD
-----
L
D
L
A
ADIAMMANFF
S
S
GQVC
TNGT
RV
FVPAKCK
A
A
F
EQKILARVERI
R
A
G
DVFDPQ
-
TNF
GPL
V
S
F
P
H
R
D
N
V
LRY
I
AK
G
KEE
G
-
AR
V
LC
G
G
--
DVLK
G
DG
F
D
N
G
A
WVA
PT
V
FTDCSDDMT
I
VR
EE
I
FGPV
M
S
L
LTYESE
D
E
V
I
RR
AND
T
D
YGL
A
A
G
I
V
T
A
DL
NR
A
H
R
V
I
HQ
L
E
A
G
IC
W
I
N
TWGESPAEM
P
V
GG
Y
K
H
SG
I
G
REN
G
VMT
L
QS
Y
TQV
K
S
I
Q
V
E
M
fig|656443.3.peg.516
Escherichia coli TA271 (1-483/490)
M
S
RMA
E
QQ
L
Y
I
H
G
GYTSATSG
---
RTFETI
NPA
N
GNV
L
ATVQA
A
GRE
D
V
D
R
AV
K
S
A
QQG
Q
--KI
W
AAMT
A
ME
R
SRI
L
R
R
AV
D
I
L
R
ERND
E
L
A
K
LE
TL
D
T
GK
AYSETSTV
D
I
VTGADVLE
Y
Y
AG
LIPALE
G
---SQI
---
PLRETSFVYTR
R
E
PLGV
V
A
G
I
G
A
WN
Y
P
IQ
I
AL
WK
SA
PALAAGN
A
M
I
F
KPSE
V
TPLTAL
KL
A
E
I
YS
EAG
L
P
D
GV
F
NV
L
P
G
V
G
AET
G
QY
LT
E
HP
G
I
AK
VS
F
TG
G
VA
S
GK
K
V
MAN
S
A
A
S
SL
K
E
V
T
M
ELGGKSP
L
IV
FD
D
-
AD
-----
L
D
L
A
ADIAMMANFF
S
S
GQVC
TNGT
RV
FVPAKCK
A
A
F
EQKILARVERI
R
A
G
DVFDPQ
-
TNF
GPL
V
S
F
P
H
R
D
N
V
LRY
I
AK
G
KEE
G
-
AR
V
LC
G
G
--
DVLK
G
DG
F
D
N
G
A
WVA
PT
V
FTDCSDDMT
I
VR
EE
I
FGPV
M
S
L
LTYESE
D
E
V
I
RR
AND
T
D
YGL
A
A
G
I
V
T
A
DL
NR
A
H
R
V
I
HQ
L
E
A
G
IC
W
I
N
TWGESPAEM
P
V
GG
Y
K
H
SG
I
G
REN
G
VMT
L
QS
Y
TQV
K
S
I
Q
V
E
M
fig|566546.3.peg.4967
Escherichia coli W (1-483/490)
M
S
RMA
E
QQ
L
Y
I
H
G
GYTSATSG
---
RTFETI
NPA
N
GNV
L
ATVQA
A
GRE
D
V
D
R
AV
K
S
A
QQG
Q
--KI
W
AAMT
A
ME
R
SRI
L
R
R
AV
D
I
L
R
ERND
E
L
A
K
LE
TL
D
T
GK
AYSETSTV
D
I
VTGADVLE
Y
Y
AG
LIPALE
G
---SQI
---
PLRETSFVYTR
R
E
PLGV
V
A
G
I
G
A
WN
Y
P
IQ
I
AL
WK
SA
PALAAGN
A
M
I
F
KPSE
V
TPLTAL
KL
A
E
I
YS
EAG
L
P
D
GV
F
NV
L
P
G
V
G
AET
G
QY
LT
E
HP
G
I
AK
VS
F
TG
G
VA
S
GK
K
V
MAN
S
A
A
S
SL
K
E
V
T
M
ELGGKSP
L
IV
FD
D
-
AD
-----
L
D
L
A
ADIAMMANFF
S
S
GQVC
TNGT
RV
FVPAKCK
A
A
F
EQKILARVERI
R
A
G
DVFDPQ
-
TNF
GPL
V
S
F
P
H
R
D
N
V
LRY
I
AK
G
KEE
G
-
AR
V
LC
G
G
--
DVLK
G
DG
F
D
N
G
A
WVA
PT
V
FTDCSDDMT
I
VR
EE
I
FGPV
M
S
L
LTYESE
D
E
V
I
RR
AND
T
D
YGL
A
A
G
I
V
T
A
DL
NR
A
H
R
V
I
HQ
L
E
A
G
IC
W
I
N
TWGESPAEM
P
V
GG
Y
K
H
SG
I
G
REN
G
VMT
L
QS
Y
TQV
K
S
I
Q
V
E
M
fig|566546.4.peg.383
Escherichia coli W (1-483/490)
M
S
RMA
E
QQ
L
Y
I
H
G
GYTSATSG
---
RTFETI
NPA
N
GNV
L
ATVQA
A
GRE
D
V
D
R
AV
K
S
A
QQG
Q
--KI
W
AAMT
A
ME
R
SRI
L
R
R
AV
D
I
L
R
ERND
E
L
A
K
LE
TL
D
T
GK
AYSETSTV
D
I
VTGADVLE
Y
Y
AG
LIPALE
G
---SQI
---
PLRETSFVYTR
R
E
PLGV
V
A
G
I
G
A
WN
Y
P
IQ
I
AL
WK
SA
PALAAGN
A
M
I
F
KPSE
V
TPLTAL
KL
A
E
I
YS
EAG
L
P
D
GV
F
NV
L
P
G
V
G
AET
G
QY
LT
E
HP
G
I
AK
VS
F
TG
G
VA
S
GK
K
V
MAN
S
A
A
S
SL
K
E
V
T
M
ELGGKSP
L
IV
FD
D
-
AD
-----
L
D
L
A
ADIAMMANFF
S
S
GQVC
TNGT
RV
FVPAKCK
A
A
F
EQKILARVERI
R
A
G
DVFDPQ
-
TNF
GPL
V
S
F
P
H
R
D
N
V
LRY
I
AK
G
KEE
G
-
AR
V
LC
G
G
--
DVLK
G
DG
F
D
N
G
A
WVA
PT
V
FTDCSDDMT
I
VR
EE
I
FGPV
M
S
L
LTYESE
D
E
V
I
RR
AND
T
D
YGL
A
A
G
I
V
T
A
DL
NR
A
H
R
V
I
HQ
L
E
A
G
IC
W
I
N
TWGESPAEM
P
V
GG
Y
K
H
SG
I
G
REN
G
VMT
L
QS
Y
TQV
K
S
I
Q
V
E
M
fig|550677.3.peg.740
Escherichia coli B354 (1-483/490)
M
S
RMA
E
QQ
L
Y
I
H
G
GYTSATSG
---
RTFETI
NPA
N
GNV
L
ATVQA
A
GRE
D
V
D
R
AV
K
S
A
QQG
Q
--KI
W
AAMT
A
ME
R
SRI
L
R
R
AV
D
I
L
R
ERND
E
L
A
K
LE
TL
D
T
GK
AYSETSTV
D
I
VTGADVLE
Y
Y
AG
LIPSLE
G
---SQI
---
PLRETSFVYTR
R
E
PLGV
V
A
G
I
G
A
WN
Y
P
IQ
I
AL
WK
SA
PALAAGN
A
M
I
F
KPSE
V
TPLTAL
KL
A
E
I
YS
EAG
L
P
D
GV
F
NV
L
P
G
V
G
AET
G
QY
LT
E
HP
G
I
AK
VS
F
TG
G
VA
S
GK
K
V
MAN
S
A
A
S
SL
K
E
V
T
M
ELGGKSP
L
IV
FD
D
-
AD
-----
L
D
L
A
ADIAMMANFF
S
S
GQVC
TNGT
RV
FIPAKCK
A
A
F
EQKILARVERI
R
A
G
DVFDPQ
-
TNF
GPL
V
S
F
P
H
R
D
N
V
LRY
I
AK
G
KEE
G
-
AR
V
LC
G
G
--
DVLK
G
DG
F
D
N
G
A
WVA
PT
V
FTDCSDEMT
I
VR
EE
I
FGPV
M
S
L
LTYESE
D
E
V
I
RR
AND
T
D
YGL
A
A
G
I
V
T
A
DL
NR
A
H
R
V
I
HQ
L
E
A
G
IC
W
I
N
TWGESPAEM
P
V
GG
Y
K
H
SG
I
G
REN
G
VMT
L
QS
Y
TQV
K
S
I
Q
V
E
M
fig|316385.5.peg.289
Escherichia coli str. K-12 substr. DH10B (3-480/487)
E
QQ
L
Y
I
H
G
GYTSATSG
---
RTFETI
NPA
N
GNV
L
ATVQA
A
GRE
D
V
D
R
AV
K
S
A
QQG
Q
--KI
W
ASMT
A
ME
R
SRI
L
R
R
AV
D
I
L
R
ERND
E
L
A
K
LE
TL
D
T
GK
AYSETSTV
D
I
VTGADVLE
Y
Y
AG
LIPALE
G
---SQI
---
PLRETSFVYTR
R
E
PLGV
V
A
G
I
G
A
WN
Y
P
IQ
I
AL
WK
SA
PALAAGN
A
M
I
F
KPSE
V
TPLTAL
KL
A
E
I
YS
EAG
L
P
D
GV
F
NV
L
P
G
V
G
AET
G
QY
LT
E
HP
G
I
AK
VS
F
TG
G
VA
S
GK
K
V
MAN
S
A
A
S
SL
K
E
V
T
M
ELGGKSP
L
IV
FD
D
-
AD
-----
L
D
L
A
ADIAMMANFF
S
S
GQVC
TNGT
RV
FVPAKCK
A
A
F
EQKILARVERI
R
A
G
DVFDPQ
-
TNF
GPL
V
S
F
P
H
R
D
N
V
LRY
I
AK
G
KEE
G
-
AR
V
LC
G
G
--
DVLK
G
DG
F
D
N
G
A
WVA
PT
V
FTDCSDDMT
I
VR
EE
I
FGPV
M
S
I
LTYESE
D
E
V
I
RR
AND
T
D
YGL
A
A
G
I
V
T
A
DL
NR
A
H
R
V
I
HQ
L
E
A
G
IC
W
I
N
TWGESPAEM
P
V
GG
Y
K
H
SG
I
G
REN
G
VMT
L
QS
Y
TQV
K
S
I
Q
V
E
M
fig|478005.5.peg.3562
Escherichia coli O157:H7 str. EC4486 (3-480/487)
E
QQ
L
Y
I
H
G
GYTSATSG
---
RTFETI
NPA
N
GNV
L
ATVQA
A
GRE
D
V
D
R
AV
K
S
A
QQG
Q
--KI
W
AAMT
A
ME
R
SRI
L
R
R
AV
D
I
L
R
ERND
E
L
A
K
LE
TL
D
T
GK
AYSETSTV
D
I
VTGADVLE
Y
Y
AG
LIPSLE
G
---SQI
---
PLRETSFVYTR
R
E
PLGV
V
A
G
I
G
A
WN
Y
P
IQ
I
AL
WK
SA
PALAAGN
A
M
I
F
KPSE
V
TPLTAL
KL
A
E
I
YS
EAG
L
P
D
GV
F
NV
L
P
G
V
G
AET
G
QY
LT
E
HP
G
I
AK
VS
F
TG
G
VA
S
GK
K
V
MAN
S
A
A
S
SL
K
E
V
T
M
ELGGKSP
L
IV
FD
D
-
AD
-----
L
D
L
A
ADIAMMANFF
S
S
GQVC
TNGT
RV
FVPAKCN
A
A
F
EQKILARVERI
R
A
G
DVFDPQ
-
TNF
GPL
V
S
F
P
H
R
D
N
V
LRY
I
AK
G
KEE
G
-
AR
V
LC
G
G
--
DVLK
G
DG
L
D
N
G
A
WVA
PT
V
FTDCSDEMT
I
VR
EE
I
FGPV
M
S
I
LTYESE
D
E
V
I
RR
AND
T
D
YGL
A
A
G
I
V
T
A
DL
NR
A
H
R
V
I
HQ
L
E
A
G
IC
W
I
N
TWGESPAEM
P
V
GG
Y
K
H
SG
I
G
REN
G
VMT
L
QS
Y
TQV
K
S
I
Q
V
E
M
fig|331112.3.peg.346
Escherichia coli HS (1-483/490)
M
S
RMA
E
QQ
L
Y
I
H
G
GYTSATSG
---
RTFETI
NPA
N
GNV
L
ATVQA
A
GRE
D
V
D
R
AV
K
S
A
QQG
Q
--KI
W
AAMT
A
ME
R
SRI
L
R
R
AV
D
I
L
R
ERND
E
L
A
K
LE
TL
D
T
GK
AYSETSTV
D
I
VTGADVLE
Y
Y
AG
LIPALE
G
---SQI
---
PLRETSFVYTR
R
E
PLGV
V
A
G
I
G
A
WN
Y
P
IQ
I
AL
WK
SA
PALAAGN
A
M
I
F
KPSE
V
TPLTAL
KL
A
E
I
YS
EAG
L
P
D
GV
F
NV
L
P
G
V
G
AET
G
QY
LT
E
HP
G
I
AK
VS
F
TG
G
VA
S
GK
K
V
MAN
S
A
A
S
SL
K
E
V
T
M
ELGGKSP
L
IV
FD
D
-
AD
-----
L
D
L
A
ADIAMMANFF
S
S
GQVC
TNGT
RV
FVPAKCK
A
A
F
EQKILARVERI
R
A
G
DVFDPQ
-
TNF
GPL
V
S
F
P
H
R
D
N
V
LRY
I
AK
G
QEE
G
-
AR
V
LC
G
G
--
DVLK
G
DG
F
D
N
G
A
WVA
PT
V
FTDCRDDMT
I
VR
EE
I
FGPV
M
S
I
LTYETE
D
E
V
I
RR
AND
T
D
YGL
A
A
G
I
V
T
A
DL
NR
A
H
R
V
I
HQ
L
E
A
G
IC
W
I
N
TWGESPAEM
P
V
GG
Y
K
H
SG
I
G
REN
G
VMT
L
QS
Y
TQV
K
S
I
Q
V
E
M
fig|331112.6.peg.365
Escherichia coli HS (1-483/490)
M
S
RMA
E
QQ
L
Y
I
H
G
GYTSATSG
---
RTFETI
NPA
N
GNV
L
ATVQA
A
GRE
D
V
D
R
AV
K
S
A
QQG
Q
--KI
W
AAMT
A
ME
R
SRI
L
R
R
AV
D
I
L
R
ERND
E
L
A
K
LE
TL
D
T
GK
AYSETSTV
D
I
VTGADVLE
Y
Y
AG
LIPALE
G
---SQI
---
PLRETSFVYTR
R
E
PLGV
V
A
G
I
G
A
WN
Y
P
IQ
I
AL
WK
SA
PALAAGN
A
M
I
F
KPSE
V
TPLTAL
KL
A
E
I
YS
EAG
L
P
D
GV
F
NV
L
P
G
V
G
AET
G
QY
LT
E
HP
G
I
AK
VS
F
TG
G
VA
S
GK
K
V
MAN
S
A
A
S
SL
K
E
V
T
M
ELGGKSP
L
IV
FD
D
-
AD
-----
L
D
L
A
ADIAMMANFF
S
S
GQVC
TNGT
RV
FVPAKCK
A
A
F
EQKILARVERI
R
A
G
DVFDPQ
-
TNF
GPL
V
S
F
P
H
R
D
N
V
LRY
I
AK
G
QEE
G
-
AR
V
LC
G
G
--
DVLK
G
DG
F
D
N
G
A
WVA
PT
V
FTDCRDDMT
I
VR
EE
I
FGPV
M
S
I
LTYETE
D
E
V
I
RR
AND
T
D
YGL
A
A
G
I
V
T
A
DL
NR
A
H
R
V
I
HQ
L
E
A
G
IC
W
I
N
TWGESPAEM
P
V
GG
Y
K
H
SG
I
G
REN
G
VMT
L
QS
Y
TQV
K
S
I
Q
V
E
M
fig|679205.4.peg.13
Escherichia coli MS 124-1 (1-483/490)
M
S
RMA
E
QQ
L
Y
I
H
G
GYTSATSG
---
RTFETI
NPA
N
GNV
L
ATVQA
A
GRE
D
V
D
R
AV
K
S
A
LQG
Q
--KI
W
ASMT
A
ME
R
SRI
L
R
R
AV
D
I
L
R
ERND
E
L
A
K
LE
TL
D
T
GK
AYSETSTV
D
I
VTGADVLE
Y
Y
AG
LIPALE
G
---SQI
---
PLRETSFVYTR
R
E
PLGV
V
A
G
I
G
A
WN
Y
P
IQ
I
AL
WK
SA
PALAAGN
A
M
I
F
KPSE
V
TPLTAL
KL
A
E
I
YS
EAG
L
P
D
GV
F
NV
L
P
G
V
G
AET
G
QY
LT
E
HP
G
I
AK
VS
F
TG
G
VA
S
GK
K
V
MAN
S
A
A
S
SL
K
E
V
T
M
ELGGKSP
L
IV
FD
D
-
AD
-----
L
D
L
A
ADIAMMANFF
S
S
GQVC
TNGT
RV
FVPAKCK
A
A
F
EQKILARVERI
R
A
G
DVFDPQ
-
TNF
GPL
V
S
F
P
H
R
D
N
V
LRY
I
AK
G
KEE
G
-
AR
V
LC
G
G
--
DVLK
G
DG
F
D
N
G
A
WVA
PT
V
FTDCSDDMT
I
VR
EE
I
FGPV
M
S
I
LTYESE
D
E
V
I
RR
AND
T
D
YGL
A
A
G
I
V
T
A
DL
NR
A
H
R
V
I
HQ
L
E
A
G
IC
W
I
N
TWGESPAEM
P
V
GG
Y
K
H
SG
I
G
REN
G
VMT
L
QS
Y
TQV
K
S
I
Q
V
E
M
fig|749533.3.peg.1489
Escherichia coli MS 84-1 (1-483/490)
M
S
RMA
E
QQ
L
Y
I
H
G
GYTSATSG
---
RTFETI
NPA
N
GNV
L
ATVQA
A
GRE
D
V
D
R
AV
K
S
A
LQG
Q
--KI
W
ASMT
A
ME
R
SRI
L
R
R
AV
D
I
L
R
ERND
E
L
A
K
LE
TL
D
T
GK
AYSETSTV
D
I
VTGADVLE
Y
Y
AG
LIPALE
G
---SQI
---
PLRETSFVYTR
R
E
PLGV
V
A
G
I
G
A
WN
Y
P
IQ
I
AL
WK
SA
PALAAGN
A
M
I
F
KPSE
V
TPLTAL
KL
A
E
I
YS
EAG
L
P
D
GV
F
NV
L
P
G
V
G
AET
G
QY
LT
E
HP
G
I
AK
VS
F
TG
G
VA
S
GK
K
V
MAN
S
A
A
S
SL
K
E
V
T
M
ELGGKSP
L
IV
FD
D
-
AD
-----
L
D
L
A
ADIAMMANFF
S
S
GQVC
TNGT
RV
FVPAKCK
A
A
F
EQKILARVERI
R
A
G
DVFDPQ
-
TNF
GPL
V
S
F
P
H
R
D
N
V
LRY
I
AK
G
KEE
G
-
AR
V
LC
G
G
--
DVLK
G
DG
F
D
N
G
A
WVA
PT
V
FTDCSDDMT
I
VR
EE
I
FGPV
M
S
I
LTYESE
D
E
V
I
RR
AND
T
D
YGL
A
A
G
I
V
T
A
DL
NR
A
H
R
V
I
HQ
L
E
A
G
IC
W
I
N
TWGESPAEM
P
V
GG
Y
K
H
SG
I
G
REN
G
VMT
L
QS
Y
TQV
K
S
I
Q
V
E
M
fig|656393.3.peg.952
Escherichia coli H299 (1-483/490)
M
S
RMA
E
QQ
L
Y
I
H
G
GYTSATSG
---
RTFETI
NPA
N
GNV
L
ATVQA
A
GRE
D
V
D
R
AV
K
S
A
QQG
Q
--KI
W
AAMT
A
ME
R
SRI
L
R
R
AV
D
I
L
R
ERND
E
L
A
K
LE
TL
D
T
GK
AYSETSTV
D
I
VTGADVLE
Y
Y
AG
LIPSLE
G
---SQI
---
PLRETSFVYTR
R
E
PLGV
V
A
G
I
G
A
WN
Y
P
IQ
I
AL
WK
SA
PALAAGN
A
M
I
F
KPSE
V
TPLTAL
KL
A
E
I
YS
EAG
L
P
D
GV
F
NV
L
P
G
V
G
AET
G
QY
LT
E
HP
G
I
AK
VS
F
TG
G
VA
S
GK
K
V
MAN
S
A
A
S
SL
K
E
V
T
M
ELGGKSP
L
IV
FD
D
-
AD
-----
L
D
L
A
ADIAMMANFF
S
S
GQVC
TNGT
RV
FIPAKCK
A
A
F
EQKILARVERI
R
A
G
DVFDPQ
-
TNF
GPL
V
S
F
P
H
R
D
N
V
LRY
I
AK
G
KEE
G
-
AR
V
LC
G
G
--
DVLK
G
DG
F
D
N
G
A
WVA
PT
V
FTDCRDEMT
I
VR
EE
I
FGPV
M
S
L
LTYESE
D
E
V
I
RR
AND
T
D
YGL
A
A
G
I
V
T
A
DL
NR
A
H
R
V
I
HQ
L
E
A
G
IC
W
I
N
TWGESPAEM
P
V
GG
Y
K
H
SG
I
G
REN
G
VMT
L
QS
Y
TQV
K
S
I
Q
V
E
M
fig|216592.1.peg.4916
Escherichia coli 042 (2-484/491)
M
S
RMA
E
QQ
L
Y
I
H
G
GYTSATSG
---
RTFETI
NPA
N
GNV
L
ATVQA
A
GRE
D
V
D
R
AV
K
S
A
QQG
Q
--KI
W
AAMT
A
ME
R
SRI
L
R
R
AV
D
I
L
R
ERND
E
L
A
K
LE
TL
D
T
GK
AYSETSTV
D
I
VTGADVLE
Y
Y
AG
LIPSLE
G
---SQI
---
PLRETSFVYTR
R
E
PLGV
V
A
G
I
G
A
WN
Y
P
IQ
I
AL
WK
SA
PALAAGN
A
M
I
F
KPSE
V
TPLTAL
KL
A
E
I
YS
EAG
L
P
D
GV
F
NV
L
P
G
V
G
AET
G
QY
LT
E
HP
G
I
AK
VS
F
TG
G
VA
S
GK
K
V
MAN
S
A
A
S
SL
K
E
V
T
M
ELGGKSP
L
IV
FD
D
-
AD
-----
L
D
L
A
ADIAMMANFF
S
S
GQVC
TNGT
RV
FVPAKCK
A
T
F
EQKILARVERI
R
A
G
DVFDPQ
-
TNF
GPL
V
S
F
P
H
R
D
N
V
LRY
I
AK
G
KEE
G
-
AR
V
LC
G
G
--
DVLK
G
DG
F
D
N
G
A
WVA
PT
V
FTDCRDEMT
I
VR
EE
I
FGPV
M
S
L
LTYESE
D
E
V
I
RR
AND
T
D
YGL
A
A
G
I
V
T
A
DL
NR
A
H
R
V
I
HQ
L
E
A
G
IC
W
I
N
TWGESPAEM
P
V
GG
Y
K
H
SG
I
G
REN
G
VMT
L
QS
Y
TQV
K
S
I
Q
V
E
M
fig|216592.3.peg.367
Escherichia coli 042 (1-483/490)
M
S
RMA
E
QQ
L
Y
I
H
G
GYTSATSG
---
RTFETI
NPA
N
GNV
L
ATVQA
A
GRE
D
V
D
R
AV
K
S
A
QQG
Q
--KI
W
AAMT
A
ME
R
SRI
L
R
R
AV
D
I
L
R
ERND
E
L
A
K
LE
TL
D
T
GK
AYSETSTV
D
I
VTGADVLE
Y
Y
AG
LIPSLE
G
---SQI
---
PLRETSFVYTR
R
E
PLGV
V
A
G
I
G
A
WN
Y
P
IQ
I
AL
WK
SA
PALAAGN
A
M
I
F
KPSE
V
TPLTAL
KL
A
E
I
YS
EAG
L
P
D
GV
F
NV
L
P
G
V
G
AET
G
QY
LT
E
HP
G
I
AK
VS
F
TG
G
VA
S
GK
K
V
MAN
S
A
A
S
SL
K
E
V
T
M
ELGGKSP
L
IV
FD
D
-
AD
-----
L
D
L
A
ADIAMMANFF
S
S
GQVC
TNGT
RV
FVPAKCK
A
T
F
EQKILARVERI
R
A
G
DVFDPQ
-
TNF
GPL
V
S
F
P
H
R
D
N
V
LRY
I
AK
G
KEE
G
-
AR
V
LC
G
G
--
DVLK
G
DG
F
D
N
G
A
WVA
PT
V
FTDCRDEMT
I
VR
EE
I
FGPV
M
S
L
LTYESE
D
E
V
I
RR
AND
T
D
YGL
A
A
G
I
V
T
A
DL
NR
A
H
R
V
I
HQ
L
E
A
G
IC
W
I
N
TWGESPAEM
P
V
GG
Y
K
H
SG
I
G
REN
G
VMT
L
QS
Y
TQV
K
S
I
Q
V
E
M
fig|656444.3.peg.768
Escherichia coli TA280 (1-483/490)
M
S
RMA
E
QQ
L
Y
I
H
G
GYTSATSG
---
RTFETI
NPA
N
GNV
L
ATVQA
A
GRE
D
V
D
R
AV
K
S
A
QQG
Q
--KI
W
AAMT
A
ME
R
SRI
L
R
R
AV
D
I
L
R
ERND
E
L
A
K
LE
TL
D
T
GK
AYSETSTV
D
I
VTGADVLE
Y
Y
AG
LIPSLE
G
---SQI
---
PLRETSFVYTR
R
E
PLGV
V
A
G
I
G
A
WN
Y
P
IQ
I
AL
WK
SA
PALAAGN
A
M
I
F
KPSE
V
TPLTAL
KL
A
E
I
YS
EAG
L
P
D
GV
F
NV
L
P
G
V
G
AET
G
QY
LT
E
HP
G
I
AK
VS
F
TG
G
VA
S
GK
K
V
MAN
S
A
A
S
SL
K
E
V
T
M
ELGGKSP
L
IV
FD
D
-
AD
-----
L
D
L
A
ADIAMMANFF
S
S
GQVC
TNGT
RV
FVPAKCK
A
A
F
EQKILARVERI
R
A
G
DVFDPQ
-
TNF
GPL
V
S
F
P
H
R
D
N
V
LRY
I
AK
G
KEE
G
-
AR
V
LC
G
G
--
DVLK
G
DG
F
D
N
G
A
WVA
PT
V
FTDCRDEMT
I
VR
EE
I
FGPV
M
S
L
LTYESE
D
E
V
I
RR
AND
T
D
YGL
A
A
G
I
V
T
A
DL
NR
A
H
R
V
I
HQ
L
E
A
G
IC
W
I
N
TWGESPAEM
P
V
GG
Y
K
H
SG
I
G
REN
G
VMT
L
QS
Y
TQV
K
S
I
Q
V
E
M
fig|481805.3.peg.3555
Escherichia coli ATCC 8739 (1-483/490)
M
S
RMA
E
QQ
L
Y
I
H
G
GYTSATSG
---
RTFETI
NPA
N
GNV
L
ATVQA
A
GRE
D
V
D
R
AV
K
S
A
QQG
Q
--KI
W
ASMT
A
ME
R
SRI
L
R
R
AV
D
I
L
R
ERND
E
L
A
K
LE
TL
D
T
GK
AYSETSTV
D
I
VTGADVLE
Y
Y
AG
LIPALE
G
---SQI
---
PLRETSFVYTR
R
E
PLGV
V
A
G
I
G
A
WN
Y
P
IQ
I
AL
WK
SA
PALAAGN
A
M
I
F
KPSE
V
TPLTAL
KL
A
E
I
YS
EAG
L
P
N
GV
F
NV
L
P
G
V
G
AET
G
QY
LT
E
HP
G
I
AK
VS
F
TG
G
VA
S
GK
K
V
MAN
S
A
A
S
SL
K
E
V
T
M
ELGGKSP
L
IV
FD
D
-
AD
-----
L
D
L
A
ADIAMMANFF
S
S
GQVC
TNGT
RV
FVPAKCK
A
A
F
EQKILARVERI
R
A
G
DVFDPQ
-
TNF
GPL
V
S
F
P
H
R
D
N
V
LRY
I
AK
G
KEE
G
-
AR
V
LC
G
G
--
DVLK
G
DG
F
D
N
G
A
WVA
PT
V
FTDCSDDMT
I
VR
EE
I
FGPV
M
S
I
LTYESE
D
E
V
I
RR
AND
T
D
YGL
A
A
G
I
V
T
A
DL
NR
A
H
R
V
I
HQ
L
E
A
G
IC
W
I
N
TWGESPAEM
P
V
GG
Y
K
H
SG
I
G
REN
G
MMT
L
QS
Y
TQV
K
S
I
Q
V
E
M
fig|481805.6.peg.3536
Escherichia coli ATCC 8739 (1-483/490)
M
S
RMA
E
QQ
L
Y
I
H
G
GYTSATSG
---
RTFETI
NPA
N
GNV
L
ATVQA
A
GRE
D
V
D
R
AV
K
S
A
QQG
Q
--KI
W
ASMT
A
ME
R
SRI
L
R
R
AV
D
I
L
R
ERND
E
L
A
K
LE
TL
D
T
GK
AYSETSTV
D
I
VTGADVLE
Y
Y
AG
LIPALE
G
---SQI
---
PLRETSFVYTR
R
E
PLGV
V
A
G
I
G
A
WN
Y
P
IQ
I
AL
WK
SA
PALAAGN
A
M
I
F
KPSE
V
TPLTAL
KL
A
E
I
YS
EAG
L
P
N
GV
F
NV
L
P
G
V
G
AET
G
QY
LT
E
HP
G
I
AK
VS
F
TG
G
VA
S
GK
K
V
MAN
S
A
A
S
SL
K
E
V
T
M
ELGGKSP
L
IV
FD
D
-
AD
-----
L
D
L
A
ADIAMMANFF
S
S
GQVC
TNGT
RV
FVPAKCK
A
A
F
EQKILARVERI
R
A
G
DVFDPQ
-
TNF
GPL
V
S
F
P
H
R
D
N
V
LRY
I
AK
G
KEE
G
-
AR
V
LC
G
G
--
DVLK
G
DG
F
D
N
G
A
WVA
PT
V
FTDCSDDMT
I
VR
EE
I
FGPV
M
S
I
LTYESE
D
E
V
I
RR
AND
T
D
YGL
A
A
G
I
V
T
A
DL
NR
A
H
R
V
I
HQ
L
E
A
G
IC
W
I
N
TWGESPAEM
P
V
GG
Y
K
H
SG
I
G
REN
G
MMT
L
QS
Y
TQV
K
S
I
Q
V
E
M
fig|340184.3.peg.766
Escherichia coli B7A (1-483/490)
M
S
RMA
E
QQ
L
Y
I
H
G
GYTSATSG
---
RTFETI
NPA
N
GNV
L
ATVQA
A
GRE
D
V
D
R
AV
K
S
A
QQG
Q
--KI
W
AAMT
A
ME
R
SRI
L
R
R
AV
D
I
L
R
ERND
E
L
A
K
LE
TL
D
T
GK
AYSETSTV
D
I
VTGADVLE
Y
Y
AG
LIPALE
G
---SQI
---
PLRETSFVYTR
R
E
PLGV
V
A
G
I
G
A
WN
Y
P
IQ
I
AL
WK
SA
PALAAGN
A
M
I
F
KPSE
V
TPLTAL
KL
A
E
I
YS
EAG
L
P
D
GV
F
NV
L
P
G
V
G
AET
G
QY
LT
E
HP
G
I
AK
VS
F
TG
G
VA
S
GK
K
V
MAN
S
A
A
S
SL
K
E
V
T
M
ELGGKSP
L
IV
FD
D
-
AD
-----
L
D
L
A
ADIAMMANFF
S
S
GQVC
TNGT
RV
FVPAKCK
A
A
F
EQKILARVERI
R
A
G
DVFDPQ
-
TNF
GPL
V
S
F
P
H
R
D
N
V
LRY
I
AK
G
KEE
G
-
AR
V
LC
G
G
--
DVLK
G
DG
F
D
N
G
A
WVA
PT
V
FTDCRDEMT
I
VR
EE
I
FGPV
M
S
L
LTYESE
D
E
V
I
RR
AND
T
D
YGL
A
A
G
I
V
T
A
DL
NR
A
H
R
V
I
HQ
L
E
A
G
IC
W
I
N
TWGESPAEM
P
V
GG
Y
K
H
SG
I
G
REN
G
VMT
L
QS
Y
TQV
K
S
I
Q
V
E
M
fig|340184.6.peg.797
Escherichia coli B7A (1-483/490)
M
S
RMA
E
QQ
L
Y
I
H
G
GYTSATSG
---
RTFETI
NPA
N
GNV
L
ATVQA
A
GRE
D
V
D
R
AV
K
S
A
QQG
Q
--KI
W
AAMT
A
ME
R
SRI
L
R
R
AV
D
I
L
R
ERND
E
L
A
K
LE
TL
D
T
GK
AYSETSTV
D
I
VTGADVLE
Y
Y
AG
LIPALE
G
---SQI
---
PLRETSFVYTR
R
E
PLGV
V
A
G
I
G
A
WN
Y
P
IQ
I
AL
WK
SA
PALAAGN
A
M
I
F
KPSE
V
TPLTAL
KL
A
E
I
YS
EAG
L
P
D
GV
F
NV
L
P
G
V
G
AET
G
QY
LT
E
HP
G
I
AK
VS
F
TG
G
VA
S
GK
K
V
MAN
S
A
A
S
SL
K
E
V
T
M
ELGGKSP
L
IV
FD
D
-
AD
-----
L
D
L
A
ADIAMMANFF
S
S
GQVC
TNGT
RV
FVPAKCK
A
A
F
EQKILARVERI
R
A
G
DVFDPQ
-
TNF
GPL
V
S
F
P
H
R
D
N
V
LRY
I
AK
G
KEE
G
-
AR
V
LC
G
G
--
DVLK
G
DG
F
D
N
G
A
WVA
PT
V
FTDCRDEMT
I
VR
EE
I
FGPV
M
S
L
LTYESE
D
E
V
I
RR
AND
T
D
YGL
A
A
G
I
V
T
A
DL
NR
A
H
R
V
I
HQ
L
E
A
G
IC
W
I
N
TWGESPAEM
P
V
GG
Y
K
H
SG
I
G
REN
G
VMT
L
QS
Y
TQV
K
S
I
Q
V
E
M
fig|340186.3.peg.1871
Escherichia coli E110019 (1-483/490)
M
S
RMA
E
QQ
L
Y
I
H
G
GYTSATSG
---
RTFETI
NPA
N
GNV
L
ATVQA
A
GRE
D
V
D
R
AV
K
S
A
QQG
Q
--KI
W
AAMT
A
ME
R
SRI
L
R
R
AV
D
I
L
R
ERND
E
L
A
K
LE
TL
D
T
GK
AYSETSTV
D
I
VTGADVLE
Y
Y
AG
LIPALE
G
---SQI
---
PLRETSFVYTR
R
E
PLGV
V
A
G
I
G
A
WN
Y
P
IQ
I
AL
WK
SA
PALAAGN
A
M
I
F
KPSE
V
TPLTAL
KL
A
E
I
YS
EAG
L
P
D
GV
F
NV
L
P
G
V
G
AET
G
QY
LT
E
HP
G
I
AK
VS
F
TG
G
VA
S
GK
K
V
MAN
S
A
A
S
SL
K
E
V
T
M
ELGGKSP
L
IV
FD
D
-
AD
-----
L
D
L
A
ADIAMMANFF
S
S
GQVC
TNGT
RV
FVPAKCK
A
A
F
EQKILARVERI
R
A
G
DVFDPQ
-
TNF
GPL
V
S
F
P
H
R
D
N
V
LRY
I
AK
G
KEE
G
-
AR
V
LC
G
G
--
DVLK
G
DG
F
D
N
G
A
WVA
PT
V
FTDCRDEMT
I
VR
EE
I
FGPV
M
S
L
LTYESE
D
E
V
I
RR
AND
T
D
YGL
A
A
G
I
V
T
A
DL
NR
A
H
R
V
I
HQ
L
E
A
G
IC
W
I
N
TWGESPAEM
P
V
GG
Y
K
H
SG
I
G
REN
G
VMT
L
QS
Y
TQV
K
S
I
Q
V
E
M
fig|340186.5.peg.1936
Escherichia coli E110019 (1-483/490)
M
S
RMA
E
QQ
L
Y
I
H
G
GYTSATSG
---
RTFETI
NPA
N
GNV
L
ATVQA
A
GRE
D
V
D
R
AV
K
S
A
QQG
Q
--KI
W
AAMT
A
ME
R
SRI
L
R
R
AV
D
I
L
R
ERND
E
L
A
K
LE
TL
D
T
GK
AYSETSTV
D
I
VTGADVLE
Y
Y
AG
LIPALE
G
---SQI
---
PLRETSFVYTR
R
E
PLGV
V
A
G
I
G
A
WN
Y
P
IQ
I
AL
WK
SA
PALAAGN
A
M
I
F
KPSE
V
TPLTAL
KL
A
E
I
YS
EAG
L
P
D
GV
F
NV
L
P
G
V
G
AET
G
QY
LT
E
HP
G
I
AK
VS
F
TG
G
VA
S
GK
K
V
MAN
S
A
A
S
SL
K
E
V
T
M
ELGGKSP
L
IV
FD
D
-
AD
-----
L
D
L
A
ADIAMMANFF
S
S
GQVC
TNGT
RV
FVPAKCK
A
A
F
EQKILARVERI
R
A
G
DVFDPQ
-
TNF
GPL
V
S
F
P
H
R
D
N
V
LRY
I
AK
G
KEE
G
-
AR
V
LC
G
G
--
DVLK
G
DG
F
D
N
G
A
WVA
PT
V
FTDCRDEMT
I
VR
EE
I
FGPV
M
S
L
LTYESE
D
E
V
I
RR
AND
T
D
YGL
A
A
G
I
V
T
A
DL
NR
A
H
R
V
I
HQ
L
E
A
G
IC
W
I
N
TWGESPAEM
P
V
GG
Y
K
H
SG
I
G
REN
G
VMT
L
QS
Y
TQV
K
S
I
Q
V
E
M
fig|679204.3.peg.3764
Escherichia coli MS 145-7 (1-483/490)
M
S
RMA
E
QQ
L
Y
I
H
G
GYTSATSG
---
RTFETI
NPA
N
GNV
L
ATVQA
A
GRE
D
V
D
R
AV
K
S
A
QQG
Q
--KI
W
AAMT
A
ME
R
SRI
L
R
R
AV
D
I
L
R
ERND
E
L
A
K
LE
TL
D
T
GK
AYSETSTV
D
I
VTGADVLE
Y
Y
AG
LIPALE
G
---SQI
---
PLRETSFVYTR
R
E
PLGV
V
A
G
I
G
A
WN
Y
P
IQ
I
AL
WK
SA
PALAAGN
A
M
I
F
KPSE
V
TPLTAL
KL
A
E
I
YS
EAG
L
P
D
GV
F
NV
L
P
G
V
G
AET
G
QY
LT
E
HP
G
I
AK
VS
F
TG
G
VA
S
GK
K
V
MAN
S
A
A
S
SL
K
E
V
T
M
ELGGKSP
L
IV
FD
D
-
AD
-----
L
D
L
A
ADIAMMANFF
S
S
GQVC
TNGT
RV
FVPAKCK
A
A
F
EQKILARVERI
R
A
G
DVFDPQ
-
TNF
GPL
V
S
F
P
H
R
D
N
V
LRY
I
AK
G
KEE
G
-
AR
V
LC
G
G
--
DVLK
G
DG
F
D
N
G
A
WVA
PT
V
FTDCRDEMT
I
VR
EE
I
FGPV
M
S
L
LTYESE
D
E
V
I
RR
AND
T
D
YGL
A
A
G
I
V
T
A
DL
NR
A
H
R
V
I
HQ
L
E
A
G
IC
W
I
N
TWGESPAEM
P
V
GG
Y
K
H
SG
I
G
REN
G
VMT
L
QS
Y
TQV
K
S
I
Q
V
E
M
fig|550676.3.peg.1100
Escherichia coli B185 (1-483/490)
M
S
RMA
E
QQ
L
Y
I
H
G
GYTSATSG
---
RTFETI
NPA
N
GNV
L
ATVQA
A
GRE
D
V
D
R
AV
K
S
A
QQG
Q
--KI
W
AAMT
A
ME
R
SRI
L
R
R
AV
D
I
L
R
ERND
E
L
A
K
LE
TL
D
T
GK
AYSETSTV
D
I
VTGADVLE
Y
Y
AG
LIPALE
G
---SQI
---
PLRETSFVYTR
R
E
PLGV
V
A
G
I
G
A
WN
Y
P
IQ
I
AL
WK
SA
PALAAGN
A
M
I
F
KPSE
V
TPLTAL
KL
A
E
I
YS
EAG
L
P
D
GV
F
NV
L
P
G
V
G
AET
G
QY
LT
E
HP
G
I
AK
VS
F
TG
G
VA
S
GK
K
V
MAN
S
A
A
S
SL
K
E
V
T
M
ELGGKSP
L
IV
FD
D
-
AD
-----
L
D
L
A
ADIAMMANFF
S
S
GQVC
TNGT
RV
FVPAKCK
A
A
F
EQKILARVERI
R
A
G
DVFDPQ
-
TNF
GPL
V
S
F
P
H
R
D
N
V
LRY
I
AK
G
KEE
G
-
AR
V
LC
G
G
--
DVLK
G
DG
L
D
N
G
A
WVA
PT
V
FTDCSDEMT
I
VR
EE
I
FGPV
M
S
I
LTYESE
EE
V
I
RR
AND
T
D
YGL
A
A
G
I
V
T
A
DL
NR
A
H
R
V
I
HQ
L
E
A
G
IC
W
I
N
TWGESPAEM
P
V
GG
Y
K
H
SG
I
G
REN
G
VMT
L
QS
Y
TQV
K
S
I
Q
V
E
M
fig|656419.3.peg.497
Escherichia coli M718 (1-483/490)
M
S
RMA
E
QQ
L
Y
I
H
G
GYTSATSG
---
RTFETI
NPA
N
GNV
L
ATVQA
A
GRE
D
V
D
R
AV
K
S
A
QQG
Q
--KI
W
AAMT
A
ME
R
SRI
L
R
R
AV
D
I
L
R
ERND
E
L
A
K
LE
TL
D
T
GK
AYSETSTV
D
I
VTGADVLE
Y
Y
AG
LIPALE
G
---SQI
---
PLRETSFVYTR
R
E
PLGV
V
A
G
I
G
A
WN
Y
P
IQ
I
AL
WK
SA
PALAAGN
A
M
I
F
KPSE
V
TPLTAL
KL
A
E
I
YS
EAG
L
P
D
GV
F
NV
L
P
G
V
G
AET
G
QY
LT
E
HP
G
I
AK
VS
F
TG
G
VA
S
GK
K
V
MAN
S
A
A
S
SL
K
E
V
T
M
ELGGKSP
L
IV
FD
D
-
AD
-----
L
D
L
A
ADIAMMANFF
S
S
GQVC
TNGT
RV
FVPAKCK
A
A
F
EQKILARVERI
R
A
G
DVFDPQ
-
TNF
GPL
V
S
F
P
H
R
D
N
V
LRY
I
AK
G
KEE
G
-
AR
V
LC
G
G
--
DVLK
G
DG
L
D
N
G
A
WVA
PT
V
FTDCSDEMT
I
VR
EE
I
FGPV
M
S
I
LTYESE
EE
V
I
RR
AND
T
D
YGL
A
A
G
I
V
T
A
DL
NR
A
H
R
V
I
HQ
L
E
A
G
IC
W
I
N
TWGESPAEM
P
V
GG
Y
K
H
SG
I
G
REN
G
VMT
L
QS
Y
TQV
K
S
I
Q
V
E
M
fig|656437.3.peg.383
Escherichia coli TA143 (1-483/490)
M
S
RMA
E
QQ
L
Y
I
H
G
GYTSATSG
---
RTFETI
NPA
N
GNV
L
ATVQA
A
GRE
D
V
D
R
AV
K
S
A
QQG
Q
--KI
W
AAMT
A
ME
R
SRI
L
R
R
AV
D
I
L
R
ERND
E
L
A
K
LE
TL
D
T
GK
AYSETSTV
D
I
VTGADVLE
Y
Y
AG
LIPSLE
G
---SQI
---
PLRETSFVYTR
R
E
PLGV
V
A
G
I
G
A
WN
Y
P
IQ
I
AL
WK
SA
PALAAGN
A
M
I
F
KPSE
V
TPLTAL
KL
A
E
I
YS
EAG
L
P
D
GV
F
NV
L
P
G
V
G
AET
G
QY
LT
D
HP
G
I
AK
VS
F
TG
G
VA
S
GK
K
V
MAN
S
A
A
S
SL
K
E
V
T
M
ELGGKSP
L
IV
FD
D
-
AD
-----
L
D
L
A
ADIAMMANFF
S
S
GQVC
TNGT
RV
FVPAKCK
A
A
F
EQKILARVERI
R
A
G
DVFDPQ
-
TNF
GPL
V
S
F
P
H
R
D
N
V
LRY
I
AK
G
KEE
G
-
AR
V
LC
G
G
--
DVLK
G
DG
F
D
N
G
A
WVA
PT
V
FTDCRDEMT
I
VR
EE
I
FGPV
M
S
L
LTYESE
D
E
V
I
RR
AND
T
D
YGL
A
A
G
I
V
T
A
DL
NR
A
H
R
V
I
HQ
L
E
A
G
IC
W
I
N
TWGESPAEM
P
V
GG
Y
K
H
SG
I
G
REN
G
VMT
L
QS
Y
TQV
K
S
I
Q
V
E
M
fig|749531.3.peg.1350
Escherichia coli MS 69-1 (1-483/490)
M
S
RMA
E
QQ
L
Y
I
H
G
GYTSATSG
---
RTFETI
NPA
N
GNV
L
ATVQA
A
GRE
D
V
D
R
AV
K
S
A
QQG
Q
--KI
W
AAMT
A
ME
R
SRI
L
H
R
AV
D
I
L
R
ERND
E
L
A
K
LE
TL
D
T
GK
AYSETSTV
D
I
VTGADVLE
Y
Y
AG
LIPSLE
G
---SQI
---
PLRETSFVYTR
R
E
PLGV
V
A
G
V
G
A
WN
Y
P
IQ
I
AL
WK
SA
PALAAGN
A
MM
F
KPSE
V
TPLTAL
KL
A
E
I
YS
EAG
L
P
D
GV
F
NV
L
P
G
V
G
AET
G
QY
LT
E
HP
G
I
AK
VS
F
TG
G
VA
S
GK
K
V
MAN
S
A
A
S
SL
K
E
V
T
M
ELGGKSP
L
IV
FD
D
-
AD
-----
L
D
L
A
ADIAMMANFF
S
S
GQVC
TNGT
RV
FIPAKCK
A
A
F
EQKILARVERI
R
A
G
DVFDPQ
-
TNF
GPL
V
S
F
P
H
R
D
N
V
LRY
I
AK
G
KEE
G
-
AR
V
LC
G
G
--
DVLK
G
DG
F
D
N
G
A
WVA
PT
V
FTDCRDEMT
I
VR
EE
I
FGPV
M
S
L
LTYESE
D
E
V
I
RR
AND
T
D
YGL
A
A
G
I
V
T
A
DL
NR
A
H
R
V
I
HQ
L
E
A
G
IC
W
I
N
TWGESPAEM
P
V
GG
Y
K
H
SG
I
G
REN
G
VMT
L
QS
Y
TQV
K
S
I
Q
V
E
M
fig|701177.3.peg.404
Escherichia coli O55:H7 str. CB9615 (1-483/490)
M
S
RMA
E
QQ
L
Y
I
H
G
GYTSATSG
---
RTFETI
NPA
N
GNV
L
ATVQA
A
GRE
D
V
D
R
AV
K
S
A
QQG
Q
--KI
W
AAMT
A
ME
R
SRI
L
R
R
AV
D
I
L
R
ERND
E
L
A
K
LE
TL
D
A
GK
AYSETSTV
D
I
VTGADVLE
Y
Y
AG
LIPSLE
G
---SQI
---
PLRETSFVYTR
R
E
PLGV
V
A
G
I
G
A
WN
Y
P
IQ
I
AL
WK
SA
PALAAGN
A
M
I
F
KPSE
V
TPLTAL
KL
A
E
I
YS
EAG
L
P
D
GV
F
NV
L
P
G
V
G
AET
G
QY
LT
E
HP
G
I
AK
VS
F
TG
G
VA
S
GK
K
V
MAN
S
A
A
S
SL
K
E
V
T
M
ELGGKSP
L
IV
FD
D
-
AD
-----
L
D
L
A
ADIAMMANFF
S
S
GQVC
TNGT
RV
FVPAKCN
A
A
F
EQKILARVERI
R
A
G
DVFDPQ
-
TNF
GPL
V
S
F
P
H
R
D
N
V
LRY
I
AK
G
KEE
G
-
AR
V
LC
G
G
--
DVLK
G
DG
L
D
N
G
A
WVA
PT
V
FTDCSDEMT
I
VR
EE
I
FGPV
M
S
I
LTYESE
D
E
V
I
RR
AND
T
D
YGL
A
A
G
I
V
T
A
DL
NR
A
H
R
V
I
HQ
L
E
A
G
IC
W
I
N
TWGESPAEM
P
V
GG
Y
K
H
SG
I
G
REN
G
VMT
L
QS
Y
TQV
K
S
I
Q
V
E
M
fig|331111.12.peg.644
Escherichia coli E24377A (1-483/490)
M
S
RMA
E
QQ
L
Y
I
H
G
GYTSATSG
---
RTFETI
NPA
N
GNV
L
ATVQA
A
GRE
D
V
D
R
AV
K
S
A
QQG
Q
--KI
W
AAMT
A
ME
R
SRI
L
R
R
AV
D
I
L
R
ERND
E
L
A
K
LE
TL
D
T
GK
AYSETSTV
D
I
VTGADVLE
Y
Y
AG
LIPSLE
G
---SQI
---
PLRETSFVYTR
R
E
PLGV
V
A
G
I
G
A
WN
Y
P
IQ
I
AL
WK
SA
PALAAGN
A
M
I
F
KPSE
V
TPLTAL
KL
A
E
I
YS
EAG
L
P
D
GV
F
NV
L
P
G
V
G
AET
G
QY
LT
E
HP
G
I
AK
VS
F
TG
G
VA
S
GK
K
V
MAN
S
A
A
S
SL
K
E
V
T
M
ELGGKSP
L
IV
FD
D
-
AD
-----
L
D
L
A
ADIAMMANFF
S
S
GQVC
TNGT
RV
FVPAKCK
A
A
F
EQKILARVERI
R
A
G
DVFDPQ
-
TNF
GPL
V
S
F
P
H
R
D
N
V
LRY
I
VK
G
KEE
G
-
AR
V
LC
G
G
--
DVLK
G
DG
L
D
N
G
A
WVA
PT
V
FTDCSDEMT
I
VR
EE
I
FGPV
M
S
I
LTYESE
EE
V
I
RR
AND
T
D
YGL
A
A
G
I
V
T
A
DL
NR
A
H
R
V
I
HQ
L
E
A
G
IC
W
I
N
TWGESPAEM
P
V
GG
Y
K
H
SG
I
G
REN
G
VMT
L
QS
Y
TQV
K
S
I
Q
V
E
M
fig|331111.3.peg.2879
Escherichia coli E24377A (1-483/490)
M
S
RMA
E
QQ
L
Y
I
H
G
GYTSATSG
---
RTFETI
NPA
N
GNV
L
ATVQA
A
GRE
D
V
D
R
AV
K
S
A
QQG
Q
--KI
W
AAMT
A
ME
R
SRI
L
R
R
AV
D
I
L
R
ERND
E
L
A
K
LE
TL
D
T
GK
AYSETSTV
D
I
VTGADVLE
Y
Y
AG
LIPSLE
G
---SQI
---
PLRETSFVYTR
R
E
PLGV
V
A
G
I
G
A
WN
Y
P
IQ
I
AL
WK
SA
PALAAGN
A
M
I
F
KPSE
V
TPLTAL
KL
A
E
I
YS
EAG
L
P
D
GV
F
NV
L
P
G
V
G
AET
G
QY
LT
E
HP
G
I
AK
VS
F
TG
G
VA
S
GK
K
V
MAN
S
A
A
S
SL
K
E
V
T
M
ELGGKSP
L
IV
FD
D
-
AD
-----
L
D
L
A
ADIAMMANFF
S
S
GQVC
TNGT
RV
FVPAKCK
A
A
F
EQKILARVERI
R
A
G
DVFDPQ
-
TNF
GPL
V
S
F
P
H
R
D
N
V
LRY
I
VK
G
KEE
G
-
AR
V
LC
G
G
--
DVLK
G
DG
L
D
N
G
A
WVA
PT
V
FTDCSDEMT
I
VR
EE
I
FGPV
M
S
I
LTYESE
EE
V
I
RR
AND
T
D
YGL
A
A
G
I
V
T
A
DL
NR
A
H
R
V
I
HQ
L
E
A
G
IC
W
I
N
TWGESPAEM
P
V
GG
Y
K
H
SG
I
G
REN
G
VMT
L
QS
Y
TQV
K
S
I
Q
V
E
M
fig|753642.3.peg.1313
Escherichia coli NC101 (1-483/490)
M
S
RMA
E
QQ
L
Y
I
H
G
GYTSATSG
---
RTFETI
NPA
N
GNV
L
ATVQA
A
GRE
D
V
D
R
AV
K
S
A
QQG
Q
--KI
W
AAMT
A
ME
R
SRI
L
R
R
AV
D
I
L
R
ERND
E
L
A
K
LE
TL
D
T
GK
AYSETSTV
D
I
VTGADVLE
Y
Y
AG
LIPALE
G
---SQI
---
PLRETSFVYTR
R
E
PLGV
V
A
G
I
G
A
WN
Y
P
IQ
I
AL
WK
SA
PALAAGN
A
M
I
F
KPSE
V
TPLTAL
KL
A
E
I
YS
EAG
L
P
D
GV
F
NV
L
P
G
V
G
AET
G
QY
LT
D
HP
G
I
AK
VS
F
TG
G
VA
S
GK
K
V
MAN
S
A
A
S
SL
K
E
V
T
M
ELGGKSP
M
IV
FD
D
-
AD
-----
L
D
L
A
ADIAMMANFF
S
S
GQVC
TNGT
RV
FVPTKCK
A
A
F
EQKVLARVERI
R
A
G
DVFDPQ
-
TNF
GPL
V
S
F
P
H
R
D
N
V
LRY
I
AK
G
IEE
G
-
AR
V
LC
G
G
--
DVLK
G
D
S
F
D
N
G
A
WVA
PT
V
FTDCSDDMT
I
VR
EE
I
FGPV
M
S
I
LIYESE
D
E
V
I
RR
AND
T
D
YGL
A
A
G
I
V
T
A
DL
NR
A
H
R
V
I
HQ
L
E
A
G
IC
W
I
N
TWGESPAEM
P
V
GG
Y
K
H
SG
I
G
REN
G
VMT
L
QS
Y
TQV
K
S
I
Q
V
E
M
fig|670888.3.peg.887
Escherichia coli 1827-70 (1-483/490)
M
S
RMA
E
QQ
L
Y
I
H
G
GYTSATSG
---
RTFETI
NPA
N
GNV
L
ATVQA
A
GRE
D
V
D
R
AV
K
S
A
QQG
Q
--KI
W
ASMT
A
ME
R
SRI
L
R
R
AV
D
I
L
R
ERND
E
L
A
K
LE
TL
D
T
GK
AYSETSTV
D
I
VTGADVLE
Y
Y
AG
LIPALE
G
---SQI
---
PLRETSFVYTR
R
E
PLGV
V
A
G
I
G
A
WN
Y
P
IQ
I
AL
WK
SA
PALAAGN
A
M
I
F
KPSE
V
TPLTAL
KL
A
E
I
YS
EAG
L
P
D
GV
F
NV
L
P
G
V
G
AET
G
QY
LT
E
HP
G
I
AK
VS
F
TG
G
VA
S
GK
K
V
MAN
S
A
A
S
SL
K
E
V
T
M
ELGGKSP
L
IV
FD
D
-
AD
-----
L
D
L
A
ADIAMMANFF
S
S
GQVC
TNGT
RV
FVPAKCK
A
A
F
EQKILARVERI
R
A
G
DVFDPQ
-
TNF
GPL
V
S
F
P
H
R
D
N
V
LRY
I
AK
G
KEE
G
-
AR
V
LC
G
G
--
DVLK
G
DG
L
D
N
G
A
WVA
PT
V
FTDCSDEMT
I
VR
EE
I
FGPV
M
S
I
LTYESE
EE
V
I
RR
AND
T
D
YGL
A
A
G
I
V
T
A
DL
NR
A
H
R
V
I
HQ
L
E
A
G
IC
W
I
N
TWGESPAEM
P
V
GG
Y
K
H
SG
I
G
REN
G
VMT
L
QS
Y
TQV
K
S
I
Q
V
E
M
fig|749545.3.peg.1889
Escherichia coli MS 182-1 (1-483/490)
M
S
RMA
E
QQ
L
Y
I
H
G
GYTSATSG
---
RTFETI
NPA
N
GNV
L
ATVQA
A
GRE
D
V
D
R
AV
K
S
A
QQG
Q
--KI
W
AAMT
A
ME
R
SRI
L
R
R
AV
D
I
L
R
ERND
E
L
A
K
LE
TL
D
T
GK
AYSETSTV
D
I
VTGADVLE
Y
Y
AG
LIPSLE
G
---SQI
---
PLRETSFVYTR
R
E
PLGV
V
A
G
I
G
A
WN
Y
P
IQ
I
AL
WK
SA
PALAAGN
A
M
I
F
KPSE
V
TPLTAL
KL
A
E
I
YS
EAG
L
P
D
GV
F
NV
L
P
G
V
G
AET
G
QY
LT
E
HP
G
I
AK
VS
F
TG
G
VA
S
GK
K
V
MAN
S
A
A
S
SL
K
E
V
T
M
ELGGKSP
L
IV
FD
D
-
AD
-----
L
D
L
A
ADIAMMANFF
S
S
GQVC
TNGT
RV
FVPAKCK
A
A
F
EQKILAHVERI
R
A
G
DVFDPQ
-
TNF
GPL
V
S
F
P
H
R
D
N
V
LRY
I
VK
G
KEE
G
-
AR
V
LC
G
G
--
DVLK
G
DG
L
D
N
G
A
WVA
PT
V
FTDCSDEMT
I
VR
EE
I
FGPV
M
S
I
LTYESE
EE
V
I
RR
AND
T
D
YGL
A
A
G
I
V
T
A
DL
NR
A
H
R
V
I
HQ
L
E
A
G
IC
W
I
N
TWGESPAEM
P
V
GG
Y
K
H
SG
I
G
REN
G
VMT
L
QS
Y
TQV
K
S
I
Q
V
E
M
fig|749532.3.peg.2768
Escherichia coli MS 78-1 (1-483/490)
M
S
RMA
E
QQ
L
Y
I
H
G
GYTSATSG
---
RTFETI
NPA
N
GNV
L
ATVQA
A
GRE
D
V
D
R
AV
K
S
A
QQG
Q
--KI
W
AAMT
A
ME
R
SRI
L
R
R
AV
D
I
L
R
ERND
E
L
A
K
LE
TL
D
T
GK
AYSETSTV
D
I
VTGADVLE
Y
Y
AG
LIPSLE
G
---SQI
---
PLRETSFVYTR
R
E
PLGV
V
A
G
I
G
A
WN
Y
P
IQ
I
AL
WK
SA
PALAAGN
A
M
I
F
KPSE
V
TPLTAL
KL
A
E
I
YS
EAG
L
P
D
GV
F
NV
L
P
G
V
G
AET
G
QY
LT
E
HP
G
I
AK
VS
F
TG
G
VA
S
GK
K
V
MAN
S
A
A
S
SL
K
E
V
T
M
ELGGKSP
L
IV
FD
D
-
AD
-----
L
D
L
A
ADIAMMANFF
S
S
GQVC
TNGT
RV
FVPAKCK
A
A
F
EQKILAHVERI
R
A
G
DVFDPQ
-
TNF
GPL
V
S
F
P
H
R
D
N
V
LRY
I
VK
G
KEE
G
-
AR
V
LC
G
G
--
DVLK
G
DG
L
D
N
G
A
WVA
PT
V
FTDCSDEMT
I
VR
EE
I
FGPV
M
S
I
LTYESE
EE
V
I
RR
AND
T
D
YGL
A
A
G
I
V
T
A
DL
NR
A
H
R
V
I
HQ
L
E
A
G
IC
W
I
N
TWGESPAEM
P
V
GG
Y
K
H
SG
I
G
REN
G
VMT
L
QS
Y
TQV
K
S
I
Q
V
E
M
fig|550672.3.peg.324
Escherichia coli B088 (3-480/487)
E
QQ
L
Y
I
H
G
GYTSATSG
---
RTFETI
NPA
N
GNV
L
ATVQA
A
GRE
D
V
D
R
AV
K
S
A
QQG
Q
--KI
W
AAMT
A
ME
R
SRI
L
R
R
AV
D
I
L
R
ERND
E
L
A
K
LE
TL
D
T
GK
AYSETSTV
D
I
VTGADVLE
Y
Y
AG
LIPALE
G
---SQI
---
PLRETLFVYTR
R
E
PLGV
V
A
G
I
G
A
WN
Y
P
IQ
I
AL
WK
SA
PALAAGN
A
M
I
F
KPSE
V
TPLTAL
KL
A
E
I
YS
EAG
L
P
D
GV
F
NV
L
P
G
V
G
AET
G
QY
LT
E
HP
G
I
AK
VS
F
TG
G
IA
S
GK
K
V
MAN
S
A
A
S
SL
K
E
V
T
M
ELGGKSP
L
IV
FD
D
-
AD
-----
L
D
L
A
ADIAMMANFF
S
S
GQVC
TNGT
RV
FVPAKCK
A
A
F
EQKILARVERI
R
A
G
DVFDPQ
-
TNF
GPL
V
S
F
P
H
R
D
N
V
LRY
I
AK
G
KEE
G
-
AR
V
LC
G
G
--
DVLK
G
DG
F
D
N
G
A
WVA
PT
V
FTDCSDDMT
I
VR
EE
I
FGPV
M
S
L
LTYESE
D
E
V
I
RR
AND
T
D
YGL
A
A
G
I
V
T
A
DL
NR
A
H
R
V
I
HQ
L
E
A
G
IC
W
I
N
TWGESPAEM
P
V
GG
Y
K
H
SG
I
G
REN
G
VMT
L
QS
Y
TQV
K
S
I
Q
V
E
M
fig|585396.4.peg.351
Escherichia coli O111:H- str. 11128 (1-483/490)
M
S
RMA
E
QQ
L
Y
I
H
G
GYTSATSG
---
RTFETI
NPA
N
GNV
L
ATVQA
A
GRE
D
V
D
R
AV
K
S
A
QQG
Q
--KI
W
AAMT
A
ME
R
SRI
L
R
R
AV
D
I
L
R
ERND
E
L
A
K
LE
TL
D
T
GK
AYSETSTV
D
I
VTGADVLE
Y
Y
AG
LIPALE
G
---SQI
---
PLRETSFVYTR
R
E
PLGV
V
A
G
I
G
A
WN
Y
P
IQ
I
AL
WK
SA
PALAAGN
A
M
I
F
KPSE
V
TPLTAL
KL
A
E
I
YS
EAG
L
P
D
GV
F
NV
L
P
G
G
G
AET
G
QY
LT
E
HP
G
I
AK
VS
F
TG
G
VA
S
GK
K
V
MAN
S
A
A
S
SL
K
E
V
T
M
ELGGKSP
L
IV
FD
D
-
AD
-----
L
D
L
A
ADIAMMANFF
S
S
GQVC
TNGT
RV
FVPAKCK
A
A
F
EQKILARVERI
R
A
G
DVFDPQ
-
TNF
GPL
V
S
F
P
H
R
D
N
V
LRY
I
AK
G
KEE
G
-
AR
V
LC
G
G
--
DVLK
G
DG
F
D
N
G
A
WVA
PT
V
FTDCRDEMT
I
VR
EE
I
FGPV
M
S
L
LTYESE
D
E
V
I
RR
AND
T
D
YGL
A
A
G
I
V
T
A
DL
NR
A
H
R
V
I
HQ
L
E
A
G
IC
W
I
N
TWGESPAEM
P
V
GG
Y
K
H
SG
I
G
REN
G
VMT
L
QS
Y
TQV
K
S
I
Q
V
E
M
fig|685038.3.peg.303
Escherichia coli O83:H1 str. NRG 857C (1-483/490)
M
S
RMA
E
QQ
L
Y
I
H
G
GYTSATSG
---
RTFETI
NPA
N
GNV
L
ATVQA
A
GRE
D
V
D
R
AV
K
S
A
QQG
Q
--KI
W
AAMT
A
ME
R
SRI
L
R
R
AV
D
I
L
R
ERND
E
L
A
K
LE
TL
D
T
GK
AYSETSTV
D
I
VTGADVLE
Y
Y
AG
LIPALE
G
---SQI
---
PLRETSFVYTR
R
E
PLGV
V
A
G
I
G
A
WN
Y
P
IQ
I
AL
WK
SA
PALAAGN
A
M
I
F
KPSE
V
TPLTAL
KL
A
E
I
YS
EAG
L
P
D
GV
F
NV
L
P
G
V
G
AET
G
QY
LT
D
HP
G
I
AK
VS
F
TG
G
VA
S
GK
K
V
MAN
S
A
A
S
SL
K
E
V
T
M
ELGGKSP
L
IV
FD
D
-
AD
-----
L
D
L
A
ADIAMMANFF
S
S
GQVC
TNGT
RV
FVPTKCK
A
A
F
EQKVLARVERI
R
A
G
DVFDPQ
-
TNF
GPL
V
S
F
P
H
R
D
N
V
LRY
I
AK
G
IEE
G
-
AR
V
LC
G
G
--
DVLK
G
D
S
F
D
N
G
A
WVA
PT
V
FTDCSDDMT
I
VR
EE
I
FGPV
M
S
I
LIYESE
D
E
V
I
RR
AND
T
D
YGL
A
A
G
I
V
T
A
DL
NR
A
H
R
V
I
HQ
L
E
A
G
IC
W
I
N
TWGESPAEM
P
V
GG
Y
K
H
SG
I
G
REN
G
VMT
L
QS
Y
TQV
K
S
I
Q
V
E
M
fig|656440.3.peg.194
Escherichia coli TA206 (1-483/490)
M
S
RMA
E
QQ
L
Y
I
H
G
GYTSATSG
---
RTFETI
NPA
N
GNV
L
ATVQA
A
GRE
D
V
D
R
AV
K
S
A
QQG
Q
--KI
W
AAMT
A
ME
R
SRI
L
R
R
AV
D
I
L
R
ERND
E
L
A
K
LE
TL
D
T
GK
AYSETSTV
D
I
VTGADVLE
Y
Y
AG
LIPALE
G
---SQI
---
PLRETSFVYTR
R
E
PLGV
V
A
G
I
G
A
WN
Y
P
IQ
I
AL
WK
SA
PALAAGN
A
M
I
F
KPSE
V
TPLTAL
KL
A
E
I
YS
EAG
L
P
D
GV
F
NV
L
P
G
V
G
AET
G
QY
LT
D
HP
G
I
AK
VS
F
TG
G
VA
S
GK
K
V
MAN
S
A
A
S
SL
K
E
V
T
M
ELGGKSP
L
IV
FD
D
-
AD
-----
L
D
L
A
ADIAMMANFF
S
S
GQVC
TNGT
RV
FVPTKCK
A
A
F
EQKVLARVERI
R
A
G
DVFDPQ
-
TNF
GPL
V
S
F
P
H
R
D
N
V
LRY
I
AK
G
IEE
G
-
AR
V
LC
G
G
--
DVLK
G
D
S
F
D
N
G
A
WVA
PT
V
FTDCSDDMT
I
VR
EE
I
FGPV
M
S
I
LIYESE
D
E
V
I
RR
AND
T
D
YGL
A
A
G
I
V
T
A
DL
NR
A
H
R
V
I
HQ
L
E
A
G
IC
W
I
N
TWGESPAEM
P
V
GG
Y
K
H
SG
I
G
REN
G
VMT
L
QS
Y
TQV
K
S
I
Q
V
E
M
fig|656379.3.peg.1180
Escherichia coli FVEC1302 (1-483/490)
M
S
RMA
E
QQ
L
Y
I
H
G
GYTSATSG
---
RTFETI
NPA
N
GNV
L
ATVQA
A
GRE
D
V
D
R
AV
K
S
A
QQG
Q
--KI
W
AAMT
A
ME
R
SRI
L
R
R
AV
D
I
L
R
ERNN
E
L
A
K
LE
TL
D
T
GK
AYSETSTV
D
I
VTGADVLE
Y
Y
AG
LIPSLE
G
---SQI
---
PLRETSFVYTR
R
E
PLGV
V
A
G
I
G
A
WN
Y
P
IQ
I
AL
WK
SA
PALAAGN
A
M
I
F
KPSE
V
TPLTAL
KL
A
E
I
YS
EAG
L
P
D
GV
F
NV
L
P
G
V
G
AET
G
QY
LT
D
HP
G
I
AK
VS
F
TG
G
VA
S
GK
K
V
MAN
S
A
A
S
SL
K
E
V
T
M
ELGGKSP
L
IV
FD
D
-
AD
-----
L
D
L
A
ADIAMMANFF
S
S
GQVC
TNGT
RV
FVPAKCK
A
A
F
EQKILARVERI
R
A
G
DVFDPQ
-
TNF
GPL
V
S
F
P
H
R
D
N
V
LRY
I
AK
G
KEE
G
-
AR
V
LC
G
G
--
DVLK
G
DG
F
D
N
G
A
WVA
PT
V
FTDCRDEMT
I
VR
EE
I
FGPV
M
S
L
LTYESE
D
E
V
I
RR
AND
T
D
YGL
A
A
G
I
V
T
A
DL
NR
A
H
R
V
I
HQ
L
E
A
G
IC
W
I
N
TWGESPAEM
P
V
GG
Y
K
H
SG
I
G
REN
G
VMT
L
QS
Y
TQV
K
S
I
Q
V
E
M
fig|656380.3.peg.937
Escherichia coli FVEC1412 (1-483/490)
M
S
RMA
E
QQ
L
Y
I
H
G
GYTSATSG
---
RTFETI
NPA
N
GNV
L
ATVQA
A
GRE
D
V
D
R
AV
K
S
A
QQG
Q
--KI
W
AAMT
A
ME
R
SRI
L
R
R
AV
D
I
L
R
ERNN
E
L
A
K
LE
TL
D
T
GK
AYSETSTV
D
I
VTGADVLE
Y
Y
AG
LIPSLE
G
---SQI
---
PLRETSFVYTR
R
E
PLGV
V
A
G
I
G
A
WN
Y
P
IQ
I
AL
WK
SA
PALAAGN
A
M
I
F
KPSE
V
TPLTAL
KL
A
E
I
YS
EAG
L
P
D
GV
F
NV
L
P
G
V
G
AET
G
QY
LT
D
HP
G
I
AK
VS
F
TG
G
VA
S
GK
K
V
MAN
S
A
A
S
SL
K
E
V
T
M
ELGGKSP
L
IV
FD
D
-
AD
-----
L
D
L
A
ADIAMMANFF
S
S
GQVC
TNGT
RV
FVPAKCK
A
A
F
EQKILARVERI
R
A
G
DVFDPQ
-
TNF
GPL
V
S
F
P
H
R
D
N
V
LRY
I
AK
G
KEE
G
-
AR
V
LC
G
G
--
DVLK
G
DG
F
D
N
G
A
WVA
PT
V
FTDCRDEMT
I
VR
EE
I
FGPV
M
S
L
LTYESE
D
E
V
I
RR
AND
T
D
YGL
A
A
G
I
V
T
A
DL
NR
A
H
R
V
I
HQ
L
E
A
G
IC
W
I
N
TWGESPAEM
P
V
GG
Y
K
H
SG
I
G
REN
G
VMT
L
QS
Y
TQV
K
S
I
Q
V
E
M
fig|585056.7.peg.549
Escherichia coli UMN026 (1-483/490)
M
S
RMA
E
QQ
L
Y
I
H
G
GYTSATSG
---
RTFETI
NPA
N
GNV
L
ATVQA
A
GRE
D
V
D
R
AV
K
S
A
QQG
Q
--KI
W
AAMT
A
ME
R
SRI
L
R
R
AV
D
I
L
R
ERNN
E
L
A
K
LE
TL
D
T
GK
AYSETSTV
D
I
VTGADVLE
Y
Y
AG
LIPSLE
G
---SQI
---
PLRETSFVYTR
R
E
PLGV
V
A
G
I
G
A
WN
Y
P
IQ
I
AL
WK
SA
PALAAGN
A
M
I
F
KPSE
V
TPLTAL
KL
A
E
I
YS
EAG
L
P
D
GV
F
NV
L
P
G
V
G
AET
G
QY
LT
D
HP
G
I
AK
VS
F
TG
G
VA
S
GK
K
V
MAN
S
A
A
S
SL
K
E
V
T
M
ELGGKSP
L
IV
FD
D
-
AD
-----
L
D
L
A
ADIAMMANFF
S
S
GQVC
TNGT
RV
FVPAKCK
A
A
F
EQKILARVERI
R
A
G
DVFDPQ
-
TNF
GPL
V
S
F
P
H
R
D
N
V
LRY
I
AK
G
KEE
G
-
AR
V
LC
G
G
--
DVLK
G
DG
F
D
N
G
A
WVA
PT
V
FTDCRDEMT
I
VR
EE
I
FGPV
M
S
L
LTYESE
D
E
V
I
RR
AND
T
D
YGL
A
A
G
I
V
T
A
DL
NR
A
H
R
V
I
HQ
L
E
A
G
IC
W
I
N
TWGESPAEM
P
V
GG
Y
K
H
SG
I
G
REN
G
VMT
L
QS
Y
TQV
K
S
I
Q
V
E
M
fig|344601.3.peg.1870
Escherichia coli B171 (1-483/490)
M
S
RMA
E
QQ
L
Y
I
H
G
GYTSATSG
---
RTFETI
NPA
N
GNV
L
ATVQA
A
GRE
D
V
D
R
AV
K
S
A
QQG
Q
--KI
W
AAMT
A
ME
R
SRI
L
R
R
AV
D
I
L
R
ERND
E
L
A
K
LE
TL
D
T
GK
AYSETSTV
D
I
VTGADVLE
Y
Y
AG
LIPALE
G
---SQI
---
PLRETLFVYTR
R
E
PLGV
V
A
G
I
G
A
WN
Y
P
IQ
I
AL
WK
SA
PALAAGN
A
M
I
F
KPSE
V
TPLTAL
KL
A
E
I
YS
EAG
L
P
D
GV
F
NV
L
P
G
V
G
AET
G
QY
LT
E
HP
G
I
AK
VS
F
TG
G
VA
S
GK
K
V
MAN
S
A
A
S
SL
K
E
V
T
M
ELGGKSP
L
IV
FD
D
-
AD
-----
L
D
L
A
ADIAMMANFF
S
S
GQVC
TNGT
RV
FVPAKCK
A
A
F
EQKILARVERI
R
A
G
DVFDPQ
-
TNF
GPL
V
S
F
P
H
R
D
N
V
LRY
I
AK
G
KEE
G
-
AR
V
LC
G
G
--
DVLK
G
DG
F
D
N
G
A
WVA
PT
V
FTDCRDEMT
I
VR
EE
I
FGPV
M
S
L
LTYESE
D
E
V
I
RR
AND
T
D
YGL
A
A
G
I
V
T
A
DL
NR
A
H
R
V
I
HQ
L
E
A
G
IC
W
I
N
TWGESPAEM
P
V
GG
Y
K
H
SG
I
G
REN
G
VMT
L
QS
Y
TQV
K
S
I
Q
V
E
M
fig|344601.5.peg.1948
Escherichia coli B171 (1-483/490)
M
S
RMA
E
QQ
L
Y
I
H
G
GYTSATSG
---
RTFETI
NPA
N
GNV
L
ATVQA
A
GRE
D
V
D
R
AV
K
S
A
QQG
Q
--KI
W
AAMT
A
ME
R
SRI
L
R
R
AV
D
I
L
R
ERND
E
L
A
K
LE
TL
D
T
GK
AYSETSTV
D
I
VTGADVLE
Y
Y
AG
LIPALE
G
---SQI
---
PLRETLFVYTR
R
E
PLGV
V
A
G
I
G
A
WN
Y
P
IQ
I
AL
WK
SA
PALAAGN
A
M
I
F
KPSE
V
TPLTAL
KL
A
E
I
YS
EAG
L
P
D
GV
F
NV
L
P
G
V
G
AET
G
QY
LT
E
HP
G
I
AK
VS
F
TG
G
VA
S
GK
K
V
MAN
S
A
A
S
SL
K
E
V
T
M
ELGGKSP
L
IV
FD
D
-
AD
-----
L
D
L
A
ADIAMMANFF
S
S
GQVC
TNGT
RV
FVPAKCK
A
A
F
EQKILARVERI
R
A
G
DVFDPQ
-
TNF
GPL
V
S
F
P
H
R
D
N
V
LRY
I
AK
G
KEE
G
-
AR
V
LC
G
G
--
DVLK
G
DG
F
D
N
G
A
WVA
PT
V
FTDCRDEMT
I
VR
EE
I
FGPV
M
S
L
LTYESE
D
E
V
I
RR
AND
T
D
YGL
A
A
G
I
V
T
A
DL
NR
A
H
R
V
I
HQ
L
E
A
G
IC
W
I
N
TWGESPAEM
P
V
GG
Y
K
H
SG
I
G
REN
G
VMT
L
QS
Y
TQV
K
S
I
Q
V
E
M
fig|340185.3.peg.2712
Escherichia coli E22 (1-483/490)
M
S
RMA
E
QQ
L
Y
I
H
G
GYTSATSG
---
RTFETI
NPA
N
GNV
L
ATVQA
A
GRE
D
V
D
R
AV
K
S
A
QQG
Q
--KI
W
AAMT
A
ME
R
SRI
L
R
R
AV
D
I
L
R
ERND
E
L
A
K
LE
TL
D
T
GK
AYSETSTV
D
I
VTGADVLE
Y
Y
AG
LIPALE
G
---SQI
---
PLRETLFVYTR
R
E
PLGV
V
A
G
I
G
A
WN
Y
P
IQ
I
AL
WK
SA
PALAAGN
A
M
I
F
KPSE
V
TPLTAL
KL
A
E
I
YS
EAG
L
P
D
GV
F
NV
L
P
G
V
G
AET
G
QY
LT
E
HP
G
I
AK
VS
F
TG
G
VA
S
GK
K
V
MAN
S
A
A
S
SL
K
E
V
T
M
ELGGKSP
L
IV
FD
D
-
AD
-----
L
D
L
A
ADIAMMANFF
S
S
GQVC
TNGT
RV
FVPAKCK
A
A
F
EQKILARVERI
R
A
G
DVFDPQ
-
TNF
GPL
V
S
F
P
H
R
D
N
V
LRY
I
AK
G
KEE
G
-
AR
V
LC
G
G
--
DVLK
G
DG
F
D
N
G
A
WVA
PT
V
FTDCRDEMT
I
VR
EE
I
FGPV
M
S
L
LTYESE
D
E
V
I
RR
AND
T
D
YGL
A
A
G
I
V
T
A
DL
NR
A
H
R
V
I
HQ
L
E
A
G
IC
W
I
N
TWGESPAEM
P
V
GG
Y
K
H
SG
I
G
REN
G
VMT
L
QS
Y
TQV
K
S
I
Q
V
E
M
fig|340185.4.peg.2856
Escherichia coli E22 (1-483/490)
M
S
RMA
E
QQ
L
Y
I
H
G
GYTSATSG
---
RTFETI
NPA
N
GNV
L
ATVQA
A
GRE
D
V
D
R
AV
K
S
A
QQG
Q
--KI
W
AAMT
A
ME
R
SRI
L
R
R
AV
D
I
L
R
ERND
E
L
A
K
LE
TL
D
T
GK
AYSETSTV
D
I
VTGADVLE
Y
Y
AG
LIPALE
G
---SQI
---
PLRETLFVYTR
R
E
PLGV
V
A
G
I
G
A
WN
Y
P
IQ
I
AL
WK
SA
PALAAGN
A
M
I
F
KPSE
V
TPLTAL
KL
A
E
I
YS
EAG
L
P
D
GV
F
NV
L
P
G
V
G
AET
G
QY
LT
E
HP
G
I
AK
VS
F
TG
G
VA
S
GK
K
V
MAN
S
A
A
S
SL
K
E
V
T
M
ELGGKSP
L
IV
FD
D
-
AD
-----
L
D
L
A
ADIAMMANFF
S
S
GQVC
TNGT
RV
FVPAKCK
A
A
F
EQKILARVERI
R
A
G
DVFDPQ
-
TNF
GPL
V
S
F
P
H
R
D
N
V
LRY
I
AK
G
KEE
G
-
AR
V
LC
G
G
--
DVLK
G
DG
F
D
N
G
A
WVA
PT
V
FTDCRDEMT
I
VR
EE
I
FGPV
M
S
L
LTYESE
D
E
V
I
RR
AND
T
D
YGL
A
A
G
I
V
T
A
DL
NR
A
H
R
V
I
HQ
L
E
A
G
IC
W
I
N
TWGESPAEM
P
V
GG
Y
K
H
SG
I
G
REN
G
VMT
L
QS
Y
TQV
K
S
I
Q
V
E
M
fig|585395.4.peg.301
Escherichia coli O103:H2 str. 12009 (1-483/490)
M
S
RMA
E
QQ
L
Y
I
H
G
GYTSATSG
---
RTFETI
NPA
N
GNV
L
ATVQA
A
GRE
D
V
D
R
AV
K
S
A
QQG
Q
--KI
W
AAMT
A
ME
R
SRI
L
R
R
AV
D
I
L
R
ERND
E
L
A
K
LE
TL
D
T
GK
AYSETSTV
D
I
VTGADVLE
Y
Y
AG
LIPALE
G
---SQI
---
PLRETLFVYTR
R
E
PLGV
V
A
G
I
G
A
WN
Y
P
IQ
I
AL
WK
SA
PALAAGN
A
M
I
F
KPSE
V
TPLTAL
KL
A
E
I
YS
EAG
L
P
D
GV
F
NV
L
P
G
V
G
AET
G
QY
LT
E
HP
G
I
AK
VS
F
TG
G
VA
S
GK
K
V
MAN
S
A
A
S
SL
K
E
V
T
M
ELGGKSP
L
IV
FD
D
-
AD
-----
L
D
L
A
ADIAMMANFF
S
S
GQVC
TNGT
RV
FVPAKCK
A
A
F
EQKILARVERI
R
A
G
DVFDPQ
-
TNF
GPL
V
S
F
P
H
R
D
N
V
LRY
I
AK
G
KEE
G
-
AR
V
LC
G
G
--
DVLK
G
DG
F
D
N
G
A
WVA
PT
V
FTDCRDEMT
I
VR
EE
I
FGPV
M
S
L
LTYESE
D
E
V
I
RR
AND
T
D
YGL
A
A
G
I
V
T
A
DL
NR
A
H
R
V
I
HQ
L
E
A
G
IC
W
I
N
TWGESPAEM
P
V
GG
Y
K
H
SG
I
G
REN
G
VMT
L
QS
Y
TQV
K
S
I
Q
V
E
M
fig|409438.11.peg.455
Escherichia coli SE11 (1-483/490)
M
S
RMA
E
QQ
L
Y
I
H
G
GYTSATSG
---
RTFETI
NPA
N
GNV
L
ATVQA
A
GRE
D
V
D
R
AV
K
S
A
QQG
Q
--KI
W
AAMT
A
ME
R
SRI
L
R
R
AV
D
I
L
R
ERND
E
L
A
K
LE
TL
D
T
GK
AYSETSTV
D
I
VTGADVLE
Y
Y
AG
LIPALE
G
---SQI
---
PLRETLFVYTR
R
E
PLGV
V
A
G
I
G
A
WN
Y
P
IQ
I
AL
WK
SA
PALAAGN
A
M
I
F
KPSE
V
TPLTAL
KL
A
E
I
YS
EAG
L
P
D
GV
F
NV
L
P
G
V
G
AET
G
QY
LT
E
HP
G
I
AK
VS
F
TG
G
VA
S
GK
K
V
MAN
S
A
A
S
SL
K
E
V
T
M
ELGGKSP
L
IV
FD
D
-
AD
-----
L
D
L
A
ADIAMMANFF
S
S
GQVC
TNGT
RV
FVPAKCK
A
A
F
EQKILARVERI
R
A
G
DVFDPQ
-
TNF
GPL
V
S
F
P
H
R
D
N
V
LRY
I
AK
G
KEE
G
-
AR
V
LC
G
G
--
DVLK
G
DG
F
D
N
G
A
WVA
PT
V
FTDCRDEMT
I
VR
EE
I
FGPV
M
S
L
LTYESE
D
E
V
I
RR
AND
T
D
YGL
A
A
G
I
V
T
A
DL
NR
A
H
R
V
I
HQ
L
E
A
G
IC
W
I
N
TWGESPAEM
P
V
GG
Y
K
H
SG
I
G
REN
G
VMT
L
QS
Y
TQV
K
S
I
Q
V
E
M
fig|216593.1.peg.3281
Escherichia coli E2348/69 (2-484/491)
M
S
RMA
E
QQ
L
Y
I
H
G
GYTSATSG
---
RTFETI
NPA
N
GNV
L
ATVQA
A
GRE
D
V
D
R
AV
K
S
A
QQG
Q
--KI
W
AAMT
A
ME
R
SRI
L
R
R
AV
D
I
L
R
ERND
E
L
A
K
LE
TL
D
T
GK
AYSETSTV
D
I
VTGADVLE
Y
Y
AG
LIPALE
G
---CQI
---
PLRETSFVYTR
R
E
PLGV
V
A
G
I
G
A
WN
Y
P
IQ
I
AL
WK
SA
PALAAGN
A
M
I
F
KPSE
V
TPLTAL
KL
A
E
I
YS
EAG
L
P
D
GV
F
NV
L
P
G
V
G
AET
G
QY
LT
D
HP
G
I
AK
VS
F
TG
G
VA
S
GK
K
V
MAN
S
A
A
S
SL
K
E
V
T
M
ELGGKSP
L
IV
FD
D
-
AD
-----
L
D
L
A
ADIAMMANFF
S
S
GQVC
TNGT
RV
FVPTKCK
A
A
F
EQKVLARVERI
R
A
G
DVFDPQ
-
TNF
GPL
V
S
F
P
H
R
D
N
V
LRY
I
AK
G
IEE
G
-
AR
V
LC
G
G
--
DVLK
G
D
S
F
D
N
G
A
WVA
PT
V
FTDCSDDMT
I
VR
EE
I
FGPV
M
S
I
LTYESE
D
E
V
I
RR
AND
T
D
YGL
A
A
G
I
V
T
A
DL
NR
A
H
R
V
I
HQ
L
E
A
G
IC
W
I
N
TWGESPAEM
P
V
GG
Y
K
H
SG
I
G
REN
G
VMT
L
QS
Y
TQV
K
S
I
Q
V
E
M
fig|670897.3.peg.390
Escherichia coli 2362-75 (1-483/490)
M
S
RMA
E
QQ
L
Y
I
H
G
GYTSATSG
---
RTFETI
NPA
N
GNV
L
ATVQA
A
GRE
D
V
D
R
AV
K
S
A
QQG
Q
--KI
W
AAMT
A
ME
R
SRI
L
R
R
AV
D
I
L
R
ERND
E
L
A
K
LE
TL
D
T
GK
AYSETSTV
D
I
VTGADVLE
Y
Y
AG
LIPALE
G
---CQI
---
PLRETSFVYTR
R
E
PLGV
V
A
G
I
G
A
WN
Y
P
IQ
I
AL
WK
SA
PALAAGN
A
M
I
F
KPSE
V
TPLTAL
KL
A
E
I
YS
EAG
L
P
D
GV
F
NV
L
P
G
V
G
AET
G
QY
LT
D
HP
G
I
AK
VS
F
TG
G
VA
S
GK
K
V
MAN
S
A
A
S
SL
K
E
V
T
M
ELGGKSP
L
IV
FD
D
-
AD
-----
L
D
L
A
ADIAMMANFF
S
S
GQVC
TNGT
RV
FVPTKCK
A
A
F
EQKVLARVERI
R
A
G
DVFDPQ
-
TNF
GPL
V
S
F
P
H
R
D
N
V
LRY
I
AK
G
IEE
G
-
AR
V
LC
G
G
--
DVLK
G
D
S
F
D
N
G
A
WVA
PT
V
FTDCSDDMT
I
VR
EE
I
FGPV
M
S
I
LTYESE
D
E
V
I
RR
AND
T
D
YGL
A
A
G
I
V
T
A
DL
NR
A
H
R
V
I
HQ
L
E
A
G
IC
W
I
N
TWGESPAEM
P
V
GG
Y
K
H
SG
I
G
REN
G
VMT
L
QS
Y
TQV
K
S
I
Q
V
E
M
fig|562.376.peg.384
Escherichia coli WV_060327 (1-483/490)
M
S
RMA
E
QQ
L
Y
I
H
G
GYTSATSG
---
RTFETI
NPA
N
GNV
L
ATVQA
A
GRE
D
V
D
R
AV
K
S
A
QQG
Q
--KI
W
AAMT
A
ME
R
SRI
L
R
R
AV
D
I
L
R
ERND
E
L
A
K
LE
TL
D
T
GK
AYSETSTV
D
I
VTGADVLE
Y
Y
AG
LIPALE
G
---CQI
---
PLRETSFVYTR
R
E
PLGV
V
A
G
I
G
A
WN
Y
P
IQ
I
AL
WK
SA
PALAAGN
A
M
I
F
KPSE
V
TPLTAL
KL
A
E
I
YS
EAG
L
P
D
GV
F
NV
L
P
G
V
G
AET
G
QY
LT
D
HP
G
I
AK
VS
F
TG
G
VA
S
GK
K
V
MAN
S
A
A
S
SL
K
E
V
T
M
ELGGKSP
L
IV
FD
D
-
AD
-----
L
D
L
A
ADIAMMANFF
S
S
GQVC
TNGT
RV
FVPTKCK
A
A
F
EQKVLARVERI
R
A
G
DVFDPQ
-
TNF
GPL
V
S
F
P
H
R
D
N
V
LRY
I
AK
G
IEE
G
-
AR
V
LC
G
G
--
DVLK
G
D
S
F
D
N
G
A
WVA
PT
V
FTDCSDDMT
I
VR
EE
I
FGPV
M
S
I
LTYESE
D
E
V
I
RR
AND
T
D
YGL
A
A
G
I
V
T
A
DL
NR
A
H
R
V
I
HQ
L
E
A
G
IC
W
I
N
TWGESPAEM
P
V
GG
Y
K
H
SG
I
G
REN
G
VMT
L
QS
Y
TQV
K
S
I
Q
V
E
M
fig|585034.4.peg.302
Escherichia coli IAI1 (1-483/490)
M
S
RMA
E
QQ
L
Y
I
H
G
GYTSATSG
---
RTFETI
NPA
N
GNV
L
ATVQA
A
GRE
D
V
D
R
AV
K
S
A
QQG
Q
--KI
W
AAMT
A
ME
R
SRI
L
R
R
AV
D
I
L
R
ERND
E
L
A
K
LE
TL
D
T
GK
AYSETSTV
D
I
VTGADVLE
Y
Y
AG
LIPALE
G
---SQI
---
PLRETLFVYTR
R
E
PLGV
V
A
G
I
G
A
WN
Y
P
IQ
I
AL
WK
SA
PALAAGN
A
M
I
F
KPSE
V
TPLTAL
KL
A
E
I
YS
EAG
L
P
D
GV
F
NV
L
P
G
V
G
AET
G
QY
LT
E
HP
G
I
AK
VS
F
TG
G
VA
S
GK
K
V
MAN
S
A
A
S
SL
K
E
V
T
M
ELGGKSP
L
IV
FD
D
-
AD
-----
L
D
L
A
ADIAMMANFF
S
S
GQVC
TNGT
RV
FVPAKCK
A
A
F
EQKILARVERI
R
A
G
DVFDPQ
-
TNF
GPL
V
S
F
P
H
R
D
N
V
LRY
I
VK
G
KEE
G
-
AR
V
LC
G
G
--
DVLK
G
DG
L
D
N
G
A
WVA
PT
V
FTDCSDEMT
I
VR
EE
I
FGPV
M
S
I
LTYESE
EE
V
I
RR
AND
T
D
YGL
A
A
G
I
V
T
A
DL
NR
A
H
R
V
I
HQ
L
E
A
G
IC
W
I
N
TWGESPAEM
P
V
GG
Y
K
H
SG
I
G
REN
G
VMT
L
QS
Y
TQV
K
S
I
Q
V
E
M
fig|585034.5.peg.301
Escherichia coli IAI1 (1-483/490)
M
S
RMA
E
QQ
L
Y
I
H
G
GYTSATSG
---
RTFETI
NPA
N
GNV
L
ATVQA
A
GRE
D
V
D
R
AV
K
S
A
QQG
Q
--KI
W
AAMT
A
ME
R
SRI
L
R
R
AV
D
I
L
R
ERND
E
L
A
K
LE
TL
D
T
GK
AYSETSTV
D
I
VTGADVLE
Y
Y
AG
LIPALE
G
---SQI
---
PLRETLFVYTR
R
E
PLGV
V
A
G
I
G
A
WN
Y
P
IQ
I
AL
WK
SA
PALAAGN
A
M
I
F
KPSE
V
TPLTAL
KL
A
E
I
YS
EAG
L
P
D
GV
F
NV
L
P
G
V
G
AET
G
QY
LT
E
HP
G
I
AK
VS
F
TG
G
VA
S
GK
K
V
MAN
S
A
A
S
SL
K
E
V
T
M
ELGGKSP
L
IV
FD
D
-
AD
-----
L
D
L
A
ADIAMMANFF
S
S
GQVC
TNGT
RV
FVPAKCK
A
A
F
EQKILARVERI
R
A
G
DVFDPQ
-
TNF
GPL
V
S
F
P
H
R
D
N
V
LRY
I
VK
G
KEE
G
-
AR
V
LC
G
G
--
DVLK
G
DG
L
D
N
G
A
WVA
PT
V
FTDCSDEMT
I
VR
EE
I
FGPV
M
S
I
LTYESE
EE
V
I
RR
AND
T
D
YGL
A
A
G
I
V
T
A
DL
NR
A
H
R
V
I
HQ
L
E
A
G
IC
W
I
N
TWGESPAEM
P
V
GG
Y
K
H
SG
I
G
REN
G
VMT
L
QS
Y
TQV
K
S
I
Q
V
E
M
fig|749549.3.peg.608
Escherichia coli MS 198-1 (1-483/490)
M
S
RMA
E
QQ
L
Y
I
H
G
GYTSATSG
---
RTFETI
NPA
N
GNV
L
ATVQA
A
GRE
D
V
D
R
AV
K
S
A
QQG
Q
--KI
W
AAMT
A
ME
R
SRI
L
R
R
AV
D
I
L
R
ERNN
E
L
A
K
LE
TL
D
T
GK
AYSETSTV
D
I
VTGADVLE
Y
Y
AG
LIPSLE
G
---SQI
---
PLRETSFVYPR
R
E
PLGV
V
A
G
I
G
A
WN
Y
P
IQ
I
AL
WK
SA
PALAAGN
A
M
I
F
KPSE
V
TPLTAL
KL
A
E
I
YS
EAG
L
P
D
GV
F
NV
L
P
G
V
G
AET
G
QY
LT
D
HP
G
I
AK
VS
F
TG
G
VA
S
GK
K
V
MAN
S
A
A
S
SL
K
E
V
T
M
ELGGKSP
L
IV
FD
D
-
AD
-----
L
D
L
A
ADIAMMANFF
S
S
GQVC
TNGT
RV
FVPAKCK
A
A
F
EQKILARVERI
R
A
G
DVFDPQ
-
TNF
GPL
V
S
F
P
H
R
D
N
V
LRY
I
AK
G
KEE
G
-
AR
V
LC
G
G
--
DVLK
G
DG
F
D
N
G
A
WVA
PT
V
FTDCRDEMT
I
VR
EE
I
FGPV
M
S
L
LTYESE
D
E
V
I
RR
AND
T
D
YGL
A
A
G
I
V
T
A
DL
NR
A
H
R
V
I
HQ
L
E
A
G
IC
W
I
N
TWGESPAEM
P
V
GG
Y
K
H
SG
I
G
REN
G
VMT
L
QS
Y
TQV
K
S
I
Q
V
E
M
fig|574521.7.peg.287
Escherichia coli O127:H6 str. E2348/69 (3-480/487)
E
QQ
L
Y
I
H
G
GYTSATSG
---
RTFETI
NPA
N
GNV
L
ATVQA
A
GRE
D
V
D
R
AV
K
S
A
QQG
Q
--KI
W
AAMT
A
ME
R
SRI
L
R
R
AV
D
I
L
R
ERND
E
L
A
K
LE
TL
D
T
GK
AYSETSTV
D
I
VTGADVLE
Y
Y
AG
LIPALE
G
---CQI
---
PLRETSFVYTR
R
E
PLGV
V
A
G
I
G
A
WN
Y
P
IQ
I
AL
WK
SA
PALAAGN
A
M
I
F
KPSE
V
TPLTAL
KL
A
E
I
YS
EAG
L
P
D
GV
F
NV
L
P
G
V
G
AET
G
QY
LT
D
HP
G
I
AK
VS
F
TG
G
VA
S
GK
K
V
MAN
S
A
A
S
SL
K
E
V
T
M
ELGGKSP
L
IV
FD
D
-
AD
-----
L
D
L
A
ADIAMMANFF
S
S
GQVC
TNGT
RV
FVPTKCK
A
A
F
EQKVLARVERI
R
A
G
DVFDPQ
-
TNF
GPL
V
S
F
P
H
R
D
N
V
LRY
I
AK
G
IEE
G
-
AR
V
LC
G
G
--
DVLK
G
D
S
F
D
N
G
A
WVA
PT
V
FTDCSDDMT
I
VR
EE
I
FGPV
M
S
I
LTYESE
D
E
V
I
RR
AND
T
D
YGL
A
A
G
I
V
T
A
DL
NR
A
H
R
V
I
HQ
L
E
A
G
IC
W
I
N
TWGESPAEM
P
V
GG
Y
K
H
SG
I
G
REN
G
VMT
L
QS
Y
TQV
K
S
I
Q
V
E
M
fig|439855.10.peg.515
Escherichia coli SMS-3-5 (1-483/490)
M
S
RMA
E
QQ
L
Y
I
H
G
GYTSATSG
---
RTFETI
NPA
N
GNV
L
ATVQA
A
GRE
D
V
D
R
AV
K
S
A
QQG
Q
--KI
W
AAMT
A
ME
R
SRI
L
R
R
AV
D
I
L
R
ERND
E
L
A
K
LE
TL
D
T
GK
AYSETSTV
D
I
VTGADVLE
Y
Y
AG
LIPALE
G
---SQI
---
PLRETSFVYTR
R
E
PLGV
V
A
G
I
G
A
WN
Y
P
IQ
I
AL
WK
SA
PALAAGN
A
M
I
F
KPSE
V
TPLTAL
KL
A
E
I
YS
EAG
L
P
D
GV
F
NV
L
P
G
V
G
AET
G
QY
LT
E
HP
G
I
AK
VS
F
TG
G
VA
S
GK
K
V
MAN
S
A
A
S
SL
K
E
V
T
M
ELGGKSP
L
IV
FD
D
-
AD
-----
L
D
L
A
ADIAMMANFF
S
S
GQVC
TNGT
RV
FVPAKCK
A
A
F
EQKILARVERI
R
A
G
DVFDPQ
-
TNF
GPL
V
S
F
P
H
R
D
N
V
LRY
I
AK
G
KEE
G
-
AR
V
LC
G
G
--
DVLK
G
DG
F
D
N
G
A
WVA
PT
V
FTDCRDEMT
I
VR
EE
I
FGPV
M
S
L
LTYESE
D
E
V
I
RR
AND
T
D
YGL
A
A
G
I
V
T
A
DL
NL
A
H
R
V
I
HQ
L
E
A
G
IC
W
I
N
TWGESPAEM
P
V
GG
Y
K
H
SG
I
G
REN
G
VMT
L
QS
Y
TQV
K
S
I
Q
V
E
M
fig|573235.3.peg.342
Escherichia coli O26:H11 str. 11368 (1-483/490)
M
S
RMA
E
QQ
L
Y
I
H
G
GYTSATSG
---
RTFETI
NPA
N
GNV
L
ATVQA
A
GRE
D
V
D
R
AV
K
S
A
QQG
Q
--KI
W
AAMT
A
ME
R
SRI
L
R
R
AV
D
I
L
R
ERND
E
L
A
K
LE
TL
D
T
GK
AYSETSTV
D
I
VTGADVLE
Y
Y
AG
LIPALE
G
---SQI
---
PLRETSFVYTR
R
E
PLGV
V
A
G
I
G
A
WN
Y
P
IQ
I
AL
WK
SA
PALAAGN
A
M
I
F
KPSE
V
TPLTAL
KL
A
E
I
YS
EAG
L
P
D
GV
F
NV
L
P
G
G
G
AET
G
QY
LT
E
HP
G
I
AK
VS
F
TG
G
VA
S
GK
K
V
MAN
S
A
A
S
SL
K
E
V
T
M
ELGGKSP
L
IV
FD
D
-
AD
-----
L
D
L
A
ADIAMMANFF
S
S
GQVC
TNGT
RV
FVPAKCK
A
A
F
EQKILARVERI
R
A
G
DVFDPQ
-
TNF
S
PL
V
S
F
P
H
R
D
N
V
LRY
I
AK
G
KEE
G
-
AR
V
LC
G
G
--
DVLK
G
DG
F
D
N
G
A
WVA
PT
V
FTDCRDEMT
I
VR
EE
I
FGPV
M
S
L
LTYESE
D
E
V
I
RR
AND
T
D
YGL
A
A
G
I
V
T
A
DL
NR
A
H
R
V
I
HQ
L
E
A
G
IC
W
I
N
TWGESPAEM
P
V
GG
Y
K
H
SG
I
G
REN
G
VMT
L
QS
Y
TQV
K
S
I
Q
V
E
M
fig|585057.4.peg.401
Escherichia coli IAI39 (1-483/490)
M
S
RMA
E
QQ
L
Y
I
H
G
GCTSATSG
---
RTFETI
NPA
N
GNV
L
ATVQA
A
GRE
D
V
D
R
AV
K
S
A
QQG
Q
--KI
W
AAMT
A
ME
R
SRI
L
R
R
AV
D
I
L
R
ERND
E
L
A
K
LE
TL
D
T
GK
AYSETSTV
D
I
VTGADVLE
Y
Y
AG
LIPALE
G
---SQI
---
PLRETSFVYTR
H
E
PLGV
V
A
G
I
G
A
WN
Y
P
IQ
I
AL
WK
SA
PALAAGN
A
M
I
F
KPSE
V
TPLTAL
KL
A
E
I
YS
EAG
L
P
D
GV
F
NV
L
P
G
V
G
AET
G
QY
LT
E
HP
G
I
AK
VS
F
TG
G
VA
S
GK
K
V
MAN
S
A
A
S
SL
K
E
V
T
M
ELGGKSP
L
IV
FD
D
-
AD
-----
L
D
L
A
ADIAMMANFF
S
S
GQVC
TNGT
RV
FIPTKCK
A
A
F
EQKILARVERI
R
A
G
DVFDPQ
-
TNF
GPL
V
S
F
P
H
R
D
N
V
LRY
I
AK
G
KEE
G
-
AR
V
LC
G
G
--
DVLK
G
D
S
F
D
N
G
A
WVA
PT
V
FTDCSDDMT
I
VR
EE
I
FGPV
M
S
I
LTYESE
D
E
V
I
RR
AND
T
D
YGL
A
A
G
I
V
T
A
DL
NR
A
H
R
V
I
HQ
L
E
A
G
IC
W
I
N
TWGESPAEM
P
V
GG
Y
K
H
SG
I
G
REN
G
VMT
L
QS
Y
TQV
K
S
I
Q
V
E
M
fig|585057.6.peg.400
Escherichia coli IAI39 (1-483/490)
M
S
RMA
E
QQ
L
Y
I
H
G
GCTSATSG
---
RTFETI
NPA
N
GNV
L
ATVQA
A
GRE
D
V
D
R
AV
K
S
A
QQG
Q
--KI
W
AAMT
A
ME
R
SRI
L
R
R
AV
D
I
L
R
ERND
E
L
A
K
LE
TL
D
T
GK
AYSETSTV
D
I
VTGADVLE
Y
Y
AG
LIPALE
G
---SQI
---
PLRETSFVYTR
H
E
PLGV
V
A
G
I
G
A
WN
Y
P
IQ
I
AL
WK
SA
PALAAGN
A
M
I
F
KPSE
V
TPLTAL
KL
A
E
I
YS
EAG
L
P
D
GV
F
NV
L
P
G
V
G
AET
G
QY
LT
E
HP
G
I
AK
VS
F
TG
G
VA
S
GK
K
V
MAN
S
A
A
S
SL
K
E
V
T
M
ELGGKSP
L
IV
FD
D
-
AD
-----
L
D
L
A
ADIAMMANFF
S
S
GQVC
TNGT
RV
FIPTKCK
A
A
F
EQKILARVERI
R
A
G
DVFDPQ
-
TNF
GPL
V
S
F
P
H
R
D
N
V
LRY
I
AK
G
KEE
G
-
AR
V
LC
G
G
--
DVLK
G
D
S
F
D
N
G
A
WVA
PT
V
FTDCSDDMT
I
VR
EE
I
FGPV
M
S
I
LTYESE
D
E
V
I
RR
AND
T
D
YGL
A
A
G
I
V
T
A
DL
NR
A
H
R
V
I
HQ
L
E
A
G
IC
W
I
N
TWGESPAEM
P
V
GG
Y
K
H
SG
I
G
REN
G
VMT
L
QS
Y
TQV
K
S
I
Q
V
E
M
fig|405955.13.peg.322
Escherichia coli APEC O1 (1-483/490)
M
S
RMA
E
QQ
L
Y
I
H
G
GYTSATSG
---
RTFETI
NPA
N
GNV
L
ATVQA
A
GRE
D
V
D
R
AV
K
S
A
QQG
Q
--KI
W
AAMT
A
ME
R
SRI
L
R
R
AV
D
I
L
R
ERND
E
L
A
K
LE
TL
D
T
GK
AYSETSTV
D
I
VTGADVLE
Y
Y
AG
LIPALE
G
---SQI
---
PLRETSFVYTR
R
E
PLGV
V
A
G
I
G
A
WN
Y
P
IQ
I
AL
WK
SA
PALAAGN
A
M
I
F
KPSE
V
TPLTAL
KL
A
E
I
YS
EAG
L
P
D
GV
F
NV
L
P
G
V
G
AET
G
QY
LT
D
HP
G
I
AK
VS
F
TG
G
VA
S
GK
K
V
MAN
S
A
A
S
SL
K
E
V
T
M
ELGGKSP
L
IV
FD
D
-
AD
-----
L
D
L
A
ADITMMANFF
S
S
GQVC
TNGT
RV
FVPTKCK
A
A
F
EQKILARVERI
R
A
G
DVFDPQ
-
TNF
GPL
V
S
F
P
H
R
D
N
V
LRY
I
AK
G
IEE
G
-
AR
V
LC
G
G
--
DVLK
G
D
S
F
D
N
G
A
WVA
PT
V
FTDCSDDMT
I
VR
EE
I
FGPV
M
S
I
LTYESE
D
E
V
I
RR
AND
T
D
YGL
A
A
G
I
V
T
A
DL
NL
A
H
R
V
I
HQ
L
E
A
G
IC
W
I
N
TWGESPAEM
P
V
GG
Y
K
H
SG
I
G
REN
G
VMT
L
QS
Y
TQV
K
S
I
Q
V
E
M
fig|714962.3.peg.310
Escherichia coli IHE3034 (1-483/490)
M
S
RMA
E
QQ
L
Y
I
H
G
GYTSATSG
---
RTFETI
NPA
N
GNV
L
ATVQA
A
GRE
D
V
D
R
AV
K
S
A
QQG
Q
--KI
W
AAMT
A
ME
R
SRI
L
R
R
AV
D
I
L
R
ERND
E
L
A
K
LE
TL
D
T
GK
AYSETSTV
D
I
VTGADVLE
Y
Y
AG
LIPALE
G
---SQI
---
PLRETSFVYTR
R
E
PLGV
V
A
G
I
G
A
WN
Y
P
IQ
I
AL
WK
SA
PALAAGN
A
M
I
F
KPSE
V
TPLTAL
KL
A
E
I
YS
EAG
L
P
D
GV
F
NV
L
P
G
V
G
AET
G
QY
LT
D
HP
G
I
AK
VS
F
TG
G
VA
S
GK
K
V
MAN
S
A
A
S
SL
K
E
V
T
M
ELGGKSP
L
IV
FD
D
-
AD
-----
L
D
L
A
ADITMMANFF
S
S
GQVC
TNGT
RV
FVPTKCK
A
A
F
EQKILARVERI
R
A
G
DVFDPQ
-
TNF
GPL
V
S
F
P
H
R
D
N
V
LRY
I
AK
G
IEE
G
-
AR
V
LC
G
G
--
DVLK
G
D
S
F
D
N
G
A
WVA
PT
V
FTDCSDDMT
I
VR
EE
I
FGPV
M
S
I
LTYESE
D
E
V
I
RR
AND
T
D
YGL
A
A
G
I
V
T
A
DL
NL
A
H
R
V
I
HQ
L
E
A
G
IC
W
I
N
TWGESPAEM
P
V
GG
Y
K
H
SG
I
G
REN
G
VMT
L
QS
Y
TQV
K
S
I
Q
V
E
M
fig|585035.6.peg.314
Escherichia coli S88 (1-483/490)
M
S
RMA
E
QQ
L
Y
I
H
G
GYTSATSG
---
RTFETI
NPA
N
GNV
L
ATVQA
A
GRE
D
V
D
R
AV
K
S
A
QQG
Q
--KI
W
AAMT
A
ME
R
SRI
L
R
R
AV
D
I
L
R
ERND
E
L
A
K
LE
TL
D
T
GK
AYSETSTV
D
I
VTGADVLE
Y
Y
AG
LIPALE
G
---SQI
---
PLRETSFVYTR
R
E
PLGV
V
A
G
I
G
A
WN
Y
P
IQ
I
AL
WK
SA
PALAAGN
A
M
I
F
KPSE
V
TPLTAL
KL
A
E
I
YS
EAG
L
P
D
GV
F
NV
L
P
G
V
G
AET
G
QY
LT
D
HP
G
I
AK
VS
F
TG
G
VA
S
GK
K
V
MAN
S
A
A
S
SL
K
E
V
T
M
ELGGKSP
L
IV
FD
D
-
AD
-----
L
D
L
A
ADITMMANFF
S
S
GQVC
TNGT
RV
FVPTKCK
A
A
F
EQKILARVERI
R
A
G
DVFDPQ
-
TNF
GPL
V
S
F
P
H
R
D
N
V
LRY
I
AK
G
IEE
G
-
AR
V
LC
G
G
--
DVLK
G
D
S
F
D
N
G
A
WVA
PT
V
FTDCSDDMT
I
VR
EE
I
FGPV
M
S
I
LTYESE
D
E
V
I
RR
AND
T
D
YGL
A
A
G
I
V
T
A
DL
NL
A
H
R
V
I
HQ
L
E
A
G
IC
W
I
N
TWGESPAEM
P
V
GG
Y
K
H
SG
I
G
REN
G
VMT
L
QS
Y
TQV
K
S
I
Q
V
E
M
fig|869729.3.peg.3373
Escherichia coli UM146 (1-483/490)
M
S
RMA
E
QQ
L
Y
I
H
G
GYTSATSG
---
RTFETI
NPA
N
GNV
L
ATVQA
A
GRE
D
V
D
R
AV
K
S
A
QQG
Q
--KI
W
AAMT
A
ME
R
SRI
L
R
R
AV
D
I
L
R
ERND
E
L
A
K
LE
TL
D
T
GK
AYSETSTV
D
I
VTGADVLE
Y
Y
AG
LIPALE
G
---SQI
---
PLRETSFVYTR
R
E
PLGV
V
A
G
I
G
A
WN
Y
P
IQ
I
AL
WK
SA
PALAAGN
A
M
I
F
KPSE
V
TPLTAL
KL
A
E
I
YS
EAG
L
P
D
GV
F
NV
L
P
G
V
G
AET
G
QY
LT
D
HP
G
I
AK
VS
F
TG
G
VA
S
GK
K
V
MAN
S
A
A
S
SL
K
E
V
T
M
ELGGKSP
L
IV
FD
D
-
AD
-----
L
D
L
A
ADITMMANFF
S
S
GQVC
TNGT
RV
FVPTKCK
A
A
F
EQKILARVERI
R
A
G
DVFDPQ
-
TNF
GPL
V
S
F
P
H
R
D
N
V
LRY
I
AK
G
IEE
G
-
AR
V
LC
G
G
--
DVLK
G
D
S
F
D
N
G
A
WVA
PT
V
FTDCSDDMT
I
VR
EE
I
FGPV
M
S
I
LTYESE
D
E
V
I
RR
AND
T
D
YGL
A
A
G
I
V
T
A
DL
NL
A
H
R
V
I
HQ
L
E
A
G
IC
W
I
N
TWGESPAEM
P
V
GG
Y
K
H
SG
I
G
REN
G
VMT
L
QS
Y
TQV
K
S
I
Q
V
E
M
fig|364106.7.peg.451
Escherichia coli UTI89 (1-483/490)
M
S
RMA
E
QQ
L
Y
I
H
G
GYTSATSG
---
RTFETI
NPA
N
GNV
L
ATVQA
A
GRE
D
V
D
R
AV
K
S
A
QQG
Q
--KI
W
AAMT
A
ME
R
SRI
L
R
R
AV
D
I
L
R
ERND
E
L
A
K
LE
TL
D
T
GK
AYSETSTV
D
I
VTGADVLE
Y
Y
AG
LIPALE
G
---SQI
---
PLRETSFVYTR
R
E
PLGV
V
A
G
I
G
A
WN
Y
P
IQ
I
AL
WK
SA
PALAAGN
A
M
I
F
KPSE
V
TPLTAL
KL
A
E
I
YS
EAG
L
P
D
GV
F
NV
L
P
G
V
G
AET
G
QY
LT
D
HP
G
I
AK
VS
F
TG
G
VA
S
GK
K
V
MAN
S
A
A
S
SL
K
E
V
T
M
ELGGKSP
L
IV
FD
D
-
AD
-----
L
D
L
A
ADITMMANFF
S
S
GQVC
TNGT
RV
FVPTKCK
A
A
F
EQKILARVERI
R
A
G
DVFDPQ
-
TNF
GPL
V
S
F
P
H
R
D
N
V
LRY
I
AK
G
IEE
G
-
AR
V
LC
G
G
--
DVLK
G
D
S
F
D
N
G
A
WVA
PT
V
FTDCSDDMT
I
VR
EE
I
FGPV
M
S
I
LTYESE
D
E
V
I
RR
AND
T
D
YGL
A
A
G
I
V
T
A
DL
NL
A
H
R
V
I
HQ
L
E
A
G
IC
W
I
N
TWGESPAEM
P
V
GG
Y
K
H
SG
I
G
REN
G
VMT
L
QS
Y
TQV
K
S
I
Q
V
E
M
fig|364106.8.peg.449
Escherichia coli UTI89 (1-483/490)
M
S
RMA
E
QQ
L
Y
I
H
G
GYTSATSG
---
RTFETI
NPA
N
GNV
L
ATVQA
A
GRE
D
V
D
R
AV
K
S
A
QQG
Q
--KI
W
AAMT
A
ME
R
SRI
L
R
R
AV
D
I
L
R
ERND
E
L
A
K
LE
TL
D
T
GK
AYSETSTV
D
I
VTGADVLE
Y
Y
AG
LIPALE
G
---SQI
---
PLRETSFVYTR
R
E
PLGV
V
A
G
I
G
A
WN
Y
P
IQ
I
AL
WK
SA
PALAAGN
A
M
I
F
KPSE
V
TPLTAL
KL
A
E
I
YS
EAG
L
P
D
GV
F
NV
L
P
G
V
G
AET
G
QY
LT
D
HP
G
I
AK
VS
F
TG
G
VA
S
GK
K
V
MAN
S
A
A
S
SL
K
E
V
T
M
ELGGKSP
L
IV
FD
D
-
AD
-----
L
D
L
A
ADITMMANFF
S
S
GQVC
TNGT
RV
FVPTKCK
A
A
F
EQKILARVERI
R
A
G
DVFDPQ
-
TNF
GPL
V
S
F
P
H
R
D
N
V
LRY
I
AK
G
IEE
G
-
AR
V
LC
G
G
--
DVLK
G
D
S
F
D
N
G
A
WVA
PT
V
FTDCSDDMT
I
VR
EE
I
FGPV
M
S
I
LTYESE
D
E
V
I
RR
AND
T
D
YGL
A
A
G
I
V
T
A
DL
NL
A
H
R
V
I
HQ
L
E
A
G
IC
W
I
N
TWGESPAEM
P
V
GG
Y
K
H
SG
I
G
REN
G
VMT
L
QS
Y
TQV
K
S
I
Q
V
E
M
fig|405955.9.peg.261
Escherichia coli APEC O1 (2-484/491)
M
S
RMA
E
QQ
L
Y
I
H
G
GYTSATSG
---
RTFETI
NPA
N
GNV
L
ATVQA
A
GRE
D
V
D
R
AV
K
S
A
QQG
Q
--KI
W
AAMT
A
ME
R
SRI
L
R
R
AV
D
I
L
R
ERND
E
L
A
K
LE
TL
D
T
GK
AYSETSTV
D
I
VTGADVLE
Y
Y
AG
LIPALE
G
---SQI
---
PLRETSFVYTR
R
E
PLGV
V
A
G
I
G
A
WN
Y
P
IQ
I
AL
WK
SA
PALAAGN
A
M
I
F
KPSE
V
TPLTAL
KL
A
E
I
YS
EAG
L
P
D
GV
F
NV
L
P
G
V
G
AET
G
QY
LT
D
HP
G
I
AK
VS
F
TG
G
VA
S
GK
K
V
MAN
S
A
A
S
SL
K
E
V
T
M
ELGGKSP
L
IV
FD
D
-
AD
-----
L
D
L
A
ADITMMANFF
S
S
GQVC
TNGT
RV
FVPTKCK
A
A
F
EQKILARVERI
R
A
G
DVFDPQ
-
TNF
GPL
V
S
F
P
H
R
D
N
V
LRY
I
AK
G
IEE
G
-
AR
V
LC
G
G
--
DVLK
G
D
S
F
D
N
G
A
WVA
PT
V
FTDCSDDMT
I
VR
EE
I
FGPV
M
S
I
LTYESE
D
E
V
I
RR
AND
T
D
YGL
A
A
G
I
V
T
A
DL
NL
A
H
R
V
I
HQ
L
E
A
G
IC
W
I
N
TWGESPAEM
P
V
GG
Y
K
H
SG
I
G
REN
G
VMT
L
QS
Y
TQV
K
S
I
Q
V
E
M
fig|656417.3.peg.454
Escherichia coli M605 (1-483/490)
M
S
RMA
E
QQ
L
Y
I
H
G
GYTSATSG
---
RTFETI
NPA
N
GNV
L
ATVQA
A
GRE
D
V
D
R
AV
K
S
A
QQG
Q
--KI
W
AAMT
A
ME
R
SRI
L
R
R
AV
D
I
L
R
ERND
E
L
A
K
LE
TL
D
S
GK
AYSETSTV
D
I
VTGADVLE
Y
Y
AG
LIPALE
G
---SQI
---
PLRETSFVYTR
R
E
PLGV
V
A
G
I
G
A
WN
Y
P
IQ
I
AL
WK
SA
PALAAGN
A
M
I
F
KPSE
V
TPLTAL
KL
A
E
I
YS
EAG
L
P
D
GV
F
NV
L
P
G
V
G
AET
G
QY
LT
D
HP
G
I
AK
VS
F
TG
G
VA
S
GK
K
V
MAN
S
A
A
S
SL
K
E
V
T
M
ELGGKSP
L
IV
FD
D
-
AD
-----
L
D
L
A
ADIAMMANFF
S
S
GQVC
TNGT
RV
FVPTKCK
A
A
F
EQKVLARVERI
R
A
G
DVFDPQ
-
TNF
GPL
V
S
F
P
H
R
D
N
V
LRY
I
AK
G
IEE
G
-
AR
V
LC
G
G
--
DVLK
G
D
S
F
D
N
G
A
WVA
PT
V
FTDCSDDMT
I
VR
EE
I
FGPV
M
S
I
LIYESE
D
E
V
I
RR
AND
T
D
YGL
A
A
G
I
V
T
A
DL
NL
A
H
R
V
I
HQ
L
E
A
G
IC
W
I
N
TWGESPAEM
P
V
GG
Y
K
H
SG
I
G
REN
G
VMT
L
QS
Y
TQV
K
S
I
Q
V
E
M
fig|656417.3.peg.1711
Escherichia coli M605 (1-472/474)
M
Q
HK
L
L
ING
ELVSG-EG
---
EKQPVY
NPAT
GDV
L
LEIAE
A
SAE
Q
V
N
A
AV
R
AA
DAA
F
--AE
W
GQTT
P
KA
R
AEC
L
L
K
LA
D
V
IE
ENGQ
V
F
A
E
LE
SR
N
C
GK
PLHSAFND
EI
PAIVDVFR
F
F
AG
AARCLN
G
LAAGEY
---
LEGHTSMI--R
R
D
PLGV
V
A
S
I
A
PWN
Y
P
LM
M
AA
WK
LA
PALAAGN
C
VV
L
KPSE
I
TPLTAL
KL
A
E
L
AK
DI
-
F
P
A
GV
I
NV
L
F
G
R
G
KTV
G
DP
LT
G
HP
K
V
RM
VS
L
TGS
IA
TG
E
H
I
ISH
T
-
A
P
S
IKR
T
H
M
ELGGK
A
P
V
IV
FD
D
-
AD
-----
I
E
A
V
VEGVRTFGYY
N
A
GQ
D
C
TAAC
R
I
YAQKGIY
D
T
L
VEKLGAAVATL
K
S
G
SPDDES
-
TEL
GPL
S
S
L
AH
L
E
R
V
SKA
V
EE
A
EAT
G
H
IK
V
IT
G
G
--
EKRK
G
--
-
-
N
GY
YYA
PTL
LAGALQDDA
I
VQ
K
E
V
FGPV
V
S
V
TLFDNE
E
QV
V
NW
ANDSQYGL
A
S
S
V
W
T
K
D
V
GR
A
H
R
V
S
AR
L
Q
Y
G
CT
WVN
THFMLVSEM
P
H
GG
Q
K
L
SG
Y
G
KDM
S
LYG
L
ED
Y
TVV
R
H
V
M
V
fig|431946.3.peg.1421
Escherichia coli SE15 (1-472/474)
M
Q
HK
L
L
ING
ELVSG-EG
---
EKQPVY
NPAT
GDV
L
LEIAE
A
SAE
Q
V
N
A
AV
R
AA
DAA
F
--AE
W
GQTT
P
KA
R
AEC
L
L
K
LA
D
V
IE
ENGQ
V
F
A
E
LE
SR
N
C
GK
PLHSAFND
EI
PAIVDVFR
F
F
AG
AARCLN
G
LAAGEY
---
LEGHTSMI--R
R
D
PLGV
V
A
S
I
A
PWN
Y
P
LM
M
AA
WK
LA
PALAAGN
C
VV
L
KPSE
I
TPLTAL
KL
A
E
L
AK
DI
-
F
P
A
GV
I
NV
L
F
G
R
G
KTV
G
DP
LT
G
HP
K
V
RM
VS
L
TGS
IA
TG
E
H
I
ISH
T
-
A
P
S
IKR
T
H
M
ELGGK
A
P
V
IV
FD
D
-
AD
-----
I
E
A
V
VEGVRTFGYY
N
A
GQ
D
C
TAAC
R
I
YAQKGIY
D
T
L
VEKLGAAVATL
K
S
G
SPDDES
-
TEL
GPL
S
S
L
AH
L
E
R
V
SKA
V
EE
A
KAT
G
H
IK
V
IT
G
G
--
EKRK
G
--
-
-
N
GY
YYA
PTL
LAGALQDDA
I
VQ
K
E
V
FGPV
V
S
V
TLFDSE
E
QV
V
NW
ANDSQYGL
A
S
S
V
W
T
K
D
V
GR
A
H
R
V
S
AR
L
Q
Y
G
CT
WVN
THFMLVSEM
P
H
GG
Q
K
L
SG
Y
G
KDM
S
LYG
L
ED
Y
TVV
R
H
V
M
V
fig|670897.3.peg.4899
Escherichia coli 2362-75 (1-472/474)
M
Q
HK
L
L
ING
ELVSG-EG
---
EKQTVY
NPAT
GDV
L
LEIAE
A
SAE
Q
V
N
A
AV
R
AA
DAA
F
--AE
W
GQTT
P
KA
R
AEC
L
L
K
LA
D
V
IE
ENGQ
V
F
A
E
LE
SR
N
C
GK
PLHSAFND
EI
PAIVDVFR
F
F
AG
AARCLN
G
LAAGEY
---
LEGHTSMI--R
R
D
PLGV
V
A
S
I
A
PWN
Y
P
LM
M
AA
WK
LA
PALAAGN
C
VV
L
KPSE
I
TPLTAL
KL
A
E
L
AK
DI
-
F
P
A
GV
I
NV
L
F
G
R
G
KTV
G
DP
LT
G
HP
K
V
RM
VS
L
TGS
IA
TG
E
H
I
ISH
T
-
A
P
S
IKR
T
H
M
ELGGK
A
P
V
IV
FD
D
-
AD
-----
I
E
A
V
VEGVRTFGYY
N
A
GQ
D
C
TAAC
R
I
YAQKGIY
D
T
L
VEKLGAAVATL
K
S
G
SPDDES
-
TEL
GPL
S
S
L
AH
L
E
R
V
SKA
V
EE
A
KAT
G
H
IK
V
IT
G
G
--
EKRK
G
--
-
-
N
GY
YYA
PTL
LAGALQDDA
I
VQ
K
E
V
FGPV
V
S
V
TLFDNE
E
QV
V
NW
ANDSQYGL
A
S
S
V
W
T
K
D
V
GR
A
H
R
V
S
AR
L
Q
Y
G
CT
WVN
THFMLVSEM
P
H
GG
Q
K
L
SG
Y
G
KDM
S
LYG
L
ED
Y
TVV
R
H
V
M
V
fig|362663.8.peg.1459
Escherichia coli 536 (1-472/474)
M
Q
HK
L
L
ING
ELVSG-EG
---
EKQPVY
NPAT
GDV
L
LEIAE
A
SAE
Q
V
N
A
AV
R
AA
DAA
F
--AE
W
GQTT
P
KA
R
AEC
L
L
K
LA
D
V
IE
ENGQ
V
F
A
E
LE
SR
N
C
GK
PLHSAFND
EI
PAIVDVFR
F
F
AG
AARCLN
G
LAAGEY
---
LEGHTSMI--R
R
D
PLGV
V
A
S
I
A
PWN
Y
P
LM
M
AA
WK
LA
PALAAGN
C
VV
L
KPSE
I
TPLTAL
KL
A
E
L
AK
DI
-
F
P
A
GV
I
NV
L
F
G
R
G
KTV
G
DP
LT
G
HP
K
V
RM
VS
L
TGS
IA
TG
E
H
I
ISH
T
-
A
P
S
IKR
T
H
M
ELGGK
A
P
V
IV
FD
D
-
AD
-----
I
E
A
V
VEGVRTFGYY
N
A
GQ
D
C
TAAC
R
I
YAQKGIY
D
T
L
VEKLGAAVATL
K
S
G
SPDDES
-
TEL
GPL
S
S
L
AH
L
E
R
V
SKA
V
EE
A
KAT
G
H
IK
V
IT
G
G
--
EKRK
G
--
-
-
N
GY
YYA
PTL
LAGALQDDA
I
VQ
K
E
V
FGPV
V
S
V
TLFDNE
E
QV
V
NW
ANDSQYGL
A
S
S
V
W
T
K
D
V
GR
A
H
R
V
S
AR
L
Q
Y
G
CT
WVN
THFMLVSEM
P
H
GG
Q
K
L
SG
Y
G
KDM
S
LYG
L
ED
Y
TVV
R
H
V
M
V
fig|362663.9.peg.1463
Escherichia coli 536 (1-472/474)
M
Q
HK
L
L
ING
ELVSG-EG
---
EKQPVY
NPAT
GDV
L
LEIAE
A
SAE
Q
V
N
A
AV
R
AA
DAA
F
--AE
W
GQTT
P
KA
R
AEC
L
L
K
LA
D
V
IE
ENGQ
V
F
A
E
LE
SR
N
C
GK
PLHSAFND
EI
PAIVDVFR
F
F
AG
AARCLN
G
LAAGEY
---
LEGHTSMI--R
R
D
PLGV
V
A
S
I
A
PWN
Y
P
LM
M
AA
WK
LA
PALAAGN
C
VV
L
KPSE
I
TPLTAL
KL
A
E
L
AK
DI
-
F
P
A
GV
I
NV
L
F
G
R
G
KTV
G
DP
LT
G
HP
K
V
RM
VS
L
TGS
IA
TG
E
H
I
ISH
T
-
A
P
S
IKR
T
H
M
ELGGK
A
P
V
IV
FD
D
-
AD
-----
I
E
A
V
VEGVRTFGYY
N
A
GQ
D
C
TAAC
R
I
YAQKGIY
D
T
L
VEKLGAAVATL
K
S
G
SPDDES
-
TEL
GPL
S
S
L
AH
L
E
R
V
SKA
V
EE
A
KAT
G
H
IK
V
IT
G
G
--
EKRK
G
--
-
-
N
GY
YYA
PTL
LAGALQDDA
I
VQ
K
E
V
FGPV
V
S
V
TLFDNE
E
QV
V
NW
ANDSQYGL
A
S
S
V
W
T
K
D
V
GR
A
H
R
V
S
AR
L
Q
Y
G
CT
WVN
THFMLVSEM
P
H
GG
Q
K
L
SG
Y
G
KDM
S
LYG
L
ED
Y
TVV
R
H
V
M
V
fig|525281.3.peg.27
Escherichia coli 83972 (1-472/474)
M
Q
HK
L
L
ING
ELVSG-EG
---
EKQPVY
NPAT
GDV
L
LEIAE
A
SAE
Q
V
N
A
AV
R
AA
DAA
F
--AE
W
GQTT
P
KA
R
AEC
L
L
K
LA
D
V
IE
ENGQ
V
F
A
E
LE
SR
N
C
GK
PLHSAFND
EI
PAIVDVFR
F
F
AG
AARCLN
G
LAAGEY
---
LEGHTSMI--R
R
D
PLGV
V
A
S
I
A
PWN
Y
P
LM
M
AA
WK
LA
PALAAGN
C
VV
L
KPSE
I
TPLTAL
KL
A
E
L
AK
DI
-
F
P
A
GV
I
NV
L
F
G
R
G
KTV
G
DP
LT
G
HP
K
V
RM
VS
L
TGS
IA
TG
E
H
I
ISH
T
-
A
P
S
IKR
T
H
M
ELGGK
A
P
V
IV
FD
D
-
AD
-----
I
E
A
V
VEGVRTFGYY
N
A
GQ
D
C
TAAC
R
I
YAQKGIY
D
T
L
VEKLGAAVATL
K
S
G
SPDDES
-
TEL
GPL
S
S
L
AH
L
E
R
V
SKA
V
EE
A
KAT
G
H
IK
V
IT
G
G
--
EKRK
G
--
-
-
N
GY
YYA
PTL
LAGALQDDA
I
VQ
K
E
V
FGPV
V
S
V
TLFDNE
E
QV
V
NW
ANDSQYGL
A
S
S
V
W
T
K
D
V
GR
A
H
R
V
S
AR
L
Q
Y
G
CT
WVN
THFMLVSEM
P
H
GG
Q
K
L
SG
Y
G
KDM
S
LYG
L
ED
Y
TVV
R
H
V
M
V
fig|655817.3.peg.1755
Escherichia coli ABU 83972 (1-472/474)
M
Q
HK
L
L
ING
ELVSG-EG
---
EKQPVY
NPAT
GDV
L
LEIAE
A
SAE
Q
V
N
A
AV
R
AA
DAA
F
--AE
W
GQTT
P
KA
R
AEC
L
L
K
LA
D
V
IE
ENGQ
V
F
A
E
LE
SR
N
C
GK
PLHSAFND
EI
PAIVDVFR
F
F
AG
AARCLN
G
LAAGEY
---
LEGHTSMI--R
R
D
PLGV
V
A
S
I
A
PWN
Y
P
LM
M
AA
WK
LA
PALAAGN
C
VV
L
KPSE
I
TPLTAL
KL
A
E
L
AK
DI
-
F
P
A
GV
I
NV
L
F
G
R
G
KTV
G
DP
LT
G
HP
K
V
RM
VS
L
TGS
IA
TG
E
H
I
ISH
T
-
A
P
S
IKR
T
H
M
ELGGK
A
P
V
IV
FD
D
-
AD
-----
I
E
A
V
VEGVRTFGYY
N
A
GQ
D
C
TAAC
R
I
YAQKGIY
D
T
L
VEKLGAAVATL
K
S
G
SPDDES
-
TEL
GPL
S
S
L
AH
L
E
R
V
SKA
V
EE
A
KAT
G
H
IK
V
IT
G
G
--
EKRK
G
--
-
-
N
GY
YYA
PTL
LAGALQDDA
I
VQ
K
E
V
FGPV
V
S
V
TLFDNE
E
QV
V
NW
ANDSQYGL
A
S
S
V
W
T
K
D
V
GR
A
H
R
V
S
AR
L
Q
Y
G
CT
WVN
THFMLVSEM
P
H
GG
Q
K
L
SG
Y
G
KDM
S
LYG
L
ED
Y
TVV
R
H
V
M
V
fig|405955.13.peg.1568
Escherichia coli APEC O1 (1-472/474)
M
Q
HK
L
L
ING
ELVSG-EG
---
EKQPVY
NPAT
GDV
L
LEIAE
A
SAE
Q
V
N
A
AV
R
AA
DAA
F
--AE
W
GQTT
P
KA
R
AEC
L
L
K
LA
D
V
IE
ENGQ
V
F
A
E
LE
SR
N
C
GK
PLHSAFND
EI
PAIVDVFR
F
F
AG
AARCLN
G
LAAGEY
---
LEGHTSMI--R
R
D
PLGV
V
A
S
I
A
PWN
Y
P
LM
M
AA
WK
LA
PALAAGN
C
VV
L
KPSE
I
TPLTAL
KL
A
E
L
AK
DI
-
F
P
A
GV
I
NV
L
F
G
R
G
KTV
G
DP
LT
G
HP
K
V
RM
VS
L
TGS
IA
TG
E
H
I
ISH
T
-
A
P
S
IKR
T
H
M
ELGGK
A
P
V
IV
FD
D
-
AD
-----
I
E
A
V
VEGVRTFGYY
N
A
GQ
D
C
TAAC
R
I
YAQKGIY
D
T
L
VEKLGAAVATL
K
S
G
SPDDES
-
TEL
GPL
S
S
L
AH
L
E
R
V
SKA
V
EE
A
KAT
G
H
IK
V
IT
G
G
--
EKRK
G
--
-
-
N
GY
YYA
PTL
LAGALQDDA
I
VQ
K
E
V
FGPV
V
S
V
TLFDNE
E
QV
V
NW
ANDSQYGL
A
S
S
V
W
T
K
D
V
GR
A
H
R
V
S
AR
L
Q
Y
G
CT
WVN
THFMLVSEM
P
H
GG
Q
K
L
SG
Y
G
KDM
S
LYG
L
ED
Y
TVV
R
H
V
M
V
fig|405955.9.peg.1280
Escherichia coli APEC O1 (1-472/474)
M
Q
HK
L
L
ING
ELVSG-EG
---
EKQPVY
NPAT
GDV
L
LEIAE
A
SAE
Q
V
N
A
AV
R
AA
DAA
F
--AE
W
GQTT
P
KA
R
AEC
L
L
K
LA
D
V
IE
ENGQ
V
F
A
E
LE
SR
N
C
GK
PLHSAFND
EI
PAIVDVFR
F
F
AG
AARCLN
G
LAAGEY
---
LEGHTSMI--R
R
D
PLGV
V
A
S
I
A
PWN
Y
P
LM
M
AA
WK
LA
PALAAGN
C
VV
L
KPSE
I
TPLTAL
KL
A
E
L
AK
DI
-
F
P
A
GV
I
NV
L
F
G
R
G
KTV
G
DP
LT
G
HP
K
V
RM
VS
L
TGS
IA
TG
E
H
I
ISH
T
-
A
P
S
IKR
T
H
M
ELGGK
A
P
V
IV
FD
D
-
AD
-----
I
E
A
V
VEGVRTFGYY
N
A
GQ
D
C
TAAC
R
I
YAQKGIY
D
T
L
VEKLGAAVATL
K
S
G
SPDDES
-
TEL
GPL
S
S
L
AH
L
E
R
V
SKA
V
EE
A
KAT
G
H
IK
V
IT
G
G
--
EKRK
G
--
-
-
N
GY
YYA
PTL
LAGALQDDA
I
VQ
K
E
V
FGPV
V
S
V
TLFDNE
E
QV
V
NW
ANDSQYGL
A
S
S
V
W
T
K
D
V
GR
A
H
R
V
S
AR
L
Q
Y
G
CT
WVN
THFMLVSEM
P
H
GG
Q
K
L
SG
Y
G
KDM
S
LYG
L
ED
Y
TVV
R
H
V
M
V
fig|199310.1.peg.1812
Escherichia coli CFT073 (1-472/474)
M
Q
HK
L
L
ING
ELVSG-EG
---
EKQPVY
NPAT
GDV
L
LEIAE
A
SAE
Q
V
N
A
AV
R
AA
DAA
F
--AE
W
GQTT
P
KA
R
AEC
L
L
K
LA
D
V
IE
ENGQ
V
F
A
E
LE
SR
N
C
GK
PLHSAFND
EI
PAIVDVFR
F
F
AG
AARCLN
G
LAAGEY
---
LEGHTSMI--R
R
D
PLGV
V
A
S
I
A
PWN
Y
P
LM
M
AA
WK
LA
PALAAGN
C
VV
L
KPSE
I
TPLTAL
KL
A
E
L
AK
DI
-
F
P
A
GV
I
NV
L
F
G
R
G
KTV
G
DP
LT
G
HP
K
V
RM
VS
L
TGS
IA
TG
E
H
I
ISH
T
-
A
P
S
IKR
T
H
M
ELGGK
A
P
V
IV
FD
D
-
AD
-----
I
E
A
V
VEGVRTFGYY
N
A
GQ
D
C
TAAC
R
I
YAQKGIY
D
T
L
VEKLGAAVATL
K
S
G
SPDDES
-
TEL
GPL
S
S
L
AH
L
E
R
V
SKA
V
EE
A
KAT
G
H
IK
V
IT
G
G
--
EKRK
G
--
-
-
N
GY
YYA
PTL
LAGALQDDA
I
VQ
K
E
V
FGPV
V
S
V
TLFDNE
E
QV
V
NW
ANDSQYGL
A
S
S
V
W
T
K
D
V
GR
A
H
R
V
S
AR
L
Q
Y
G
CT
WVN
THFMLVSEM
P
H
GG
Q
K
L
SG
Y
G
KDM
S
LYG
L
ED
Y
TVV
R
H
V
M
V
fig|199310.4.peg.1743
Escherichia coli CFT073 (1-472/474)
M
Q
HK
L
L
ING
ELVSG-EG
---
EKQPVY
NPAT
GDV
L
LEIAE
A
SAE
Q
V
N
A
AV
R
AA
DAA
F
--AE
W
GQTT
P
KA
R
AEC
L
L
K
LA
D
V
IE
ENGQ
V
F
A
E
LE
SR
N
C
GK
PLHSAFND
EI
PAIVDVFR
F
F
AG
AARCLN
G
LAAGEY
---
LEGHTSMI--R
R
D
PLGV
V
A
S
I
A
PWN
Y
P
LM
M
AA
WK
LA
PALAAGN
C
VV
L
KPSE
I
TPLTAL
KL
A
E
L
AK
DI
-
F
P
A
GV
I
NV
L
F
G
R
G
KTV
G
DP
LT
G
HP
K
V
RM
VS
L
TGS
IA
TG
E
H
I
ISH
T
-
A
P
S
IKR
T
H
M
ELGGK
A
P
V
IV
FD
D
-
AD
-----
I
E
A
V
VEGVRTFGYY
N
A
GQ
D
C
TAAC
R
I
YAQKGIY
D
T
L
VEKLGAAVATL
K
S
G
SPDDES
-
TEL
GPL
S
S
L
AH
L
E
R
V
SKA
V
EE
A
KAT
G
H
IK
V
IT
G
G
--
EKRK
G
--
-
-
N
GY
YYA
PTL
LAGALQDDA
I
VQ
K
E
V
FGPV
V
S
V
TLFDNE
E
QV
V
NW
ANDSQYGL
A
S
S
V
W
T
K
D
V
GR
A
H
R
V
S
AR
L
Q
Y
G
CT
WVN
THFMLVSEM
P
H
GG
Q
K
L
SG
Y
G
KDM
S
LYG
L
ED
Y
TVV
R
H
V
M
V
fig|585397.7.peg.1610
Escherichia coli ED1a (1-472/474)
M
Q
HK
L
L
ING
ELVSG-EG
---
EKQPVY
NPAT
GDV
L
LEIAE
A
SAE
Q
V
N
A
AV
R
AA
DAA
F
--AE
W
GQTT
P
KA
R
AEC
L
L
K
LA
D
V
IE
ENGQ
V
F
A
E
LE
SR
N
C
GK
PLHSAFND
EI
PAIVDVFR
F
F
AG
AARCLN
G
LAAGEY
---
LEGHTSMI--R
R
D
PLGV
V
A
S
I
A
PWN
Y
P
LM
M
AA
WK
LA
PALAAGN
C
VV
L
KPSE
I
TPLTAL
KL
A
E
L
AK
DI
-
F
P
A
GV
I
NV
L
F
G
R
G
KTV
G
DP
LT
G
HP
K
V
RM
VS
L
TGS
IA
TG
E
H
I
ISH
T
-
A
P
S
IKR
T
H
M
ELGGK
A
P
V
IV
FD
D
-
AD
-----
I
E
A
V
VEGVRTFGYY
N
A
GQ
D
C
TAAC
R
I
YAQKGIY
D
T
L
VEKLGAAVATL
K
S
G
SPDDES
-
TEL
GPL
S
S
L
AH
L
E
R
V
SKA
V
EE
A
KAT
G
H
IK
V
IT
G
G
--
EKRK
G
--
-
-
N
GY
YYA
PTL
LAGALQDDA
I
VQ
K
E
V
FGPV
V
S
V
TLFDNE
E
QV
V
NW
ANDSQYGL
A
S
S
V
W
T
K
D
V
GR
A
H
R
V
S
AR
L
Q
Y
G
CT
WVN
THFMLVSEM
P
H
GG
Q
K
L
SG
Y
G
KDM
S
LYG
L
ED
Y
TVV
R
H
V
M
V
fig|585397.9.peg.1603
Escherichia coli ED1a (1-472/474)
M
Q
HK
L
L
ING
ELVSG-EG
---
EKQPVY
NPAT
GDV
L
LEIAE
A
SAE
Q
V
N
A
AV
R
AA
DAA
F
--AE
W
GQTT
P
KA
R
AEC
L
L
K
LA
D
V
IE
ENGQ
V
F
A
E
LE
SR
N
C
GK
PLHSAFND
EI
PAIVDVFR
F
F
AG
AARCLN
G
LAAGEY
---
LEGHTSMI--R
R
D
PLGV
V
A
S
I
A
PWN
Y
P
LM
M
AA
WK
LA
PALAAGN
C
VV
L
KPSE
I
TPLTAL
KL
A
E
L
AK
DI
-
F
P
A
GV
I
NV
L
F
G
R
G
KTV
G
DP
LT
G
HP
K
V
RM
VS
L
TGS
IA
TG
E
H
I
ISH
T
-
A
P
S
IKR
T
H
M
ELGGK
A
P
V
IV
FD
D
-
AD
-----
I
E
A
V
VEGVRTFGYY
N
A
GQ
D
C
TAAC
R
I
YAQKGIY
D
T
L
VEKLGAAVATL
K
S
G
SPDDES
-
TEL
GPL
S
S
L
AH
L
E
R
V
SKA
V
EE
A
KAT
G
H
IK
V
IT
G
G
--
EKRK
G
--
-
-
N
GY
YYA
PTL
LAGALQDDA
I
VQ
K
E
V
FGPV
V
S
V
TLFDNE
E
QV
V
NW
ANDSQYGL
A
S
S
V
W
T
K
D
V
GR
A
H
R
V
S
AR
L
Q
Y
G
CT
WVN
THFMLVSEM
P
H
GG
Q
K
L
SG
Y
G
KDM
S
LYG
L
ED
Y
TVV
R
H
V
M
V
fig|340197.3.peg.2994
Escherichia coli F11 (1-472/474)
M
Q
HK
L
L
ING
ELVSG-EG
---
EKQPVY
NPAT
GDV
L
LEIAE
A
SAE
Q
V
N
A
AV
R
AA
DAA
F
--AE
W
GQTT
P
KA
R
AEC
L
L
K
LA
D
V
IE
ENGQ
V
F
A
E
LE
SR
N
C
GK
PLHSAFND
EI
PAIVDVFR
F
F
AG
AARCLN
G
LAAGEY
---
LEGHTSMI--R
R
D
PLGV
V
A
S
I
A
PWN
Y
P
LM
M
AA
WK
LA
PALAAGN
C
VV
L
KPSE
I
TPLTAL
KL
A
E
L
AK
DI
-
F
P
A
GV
I
NV
L
F
G
R
G
KTV
G
DP
LT
G
HP
K
V
RM
VS
L
TGS
IA
TG
E
H
I
ISH
T
-
A
P
S
IKR
T
H
M
ELGGK
A
P
V
IV
FD
D
-
AD
-----
I
E
A
V
VEGVRTFGYY
N
A
GQ
D
C
TAAC
R
I
YAQKGIY
D
T
L
VEKLGAAVATL
K
S
G
SPDDES
-
TEL
GPL
S
S
L
AH
L
E
R
V
SKA
V
EE
A
KAT
G
H
IK
V
IT
G
G
--
EKRK
G
--
-
-
N
GY
YYA
PTL
LAGALQDDA
I
VQ
K
E
V
FGPV
V
S
V
TLFDNE
E
QV
V
NW
ANDSQYGL
A
S
S
V
W
T
K
D
V
GR
A
H
R
V
S
AR
L
Q
Y
G
CT
WVN
THFMLVSEM
P
H
GG
Q
K
L
SG
Y
G
KDM
S
LYG
L
ED
Y
TVV
R
H
V
M
V
fig|340197.5.peg.3129
Escherichia coli F11 (1-472/474)
M
Q
HK
L
L
ING
ELVSG-EG
---
EKQPVY
NPAT
GDV
L
LEIAE
A
SAE
Q
V
N
A
AV
R
AA
DAA
F
--AE
W
GQTT
P
KA
R
AEC
L
L
K
LA
D
V
IE
ENGQ
V
F
A
E
LE
SR
N
C
GK
PLHSAFND
EI
PAIVDVFR
F
F
AG
AARCLN
G
LAAGEY
---
LEGHTSMI--R
R
D
PLGV
V
A
S
I
A
PWN
Y
P
LM
M
AA
WK
LA
PALAAGN
C
VV
L
KPSE
I
TPLTAL
KL
A
E
L
AK
DI
-
F
P
A
GV
I
NV
L
F
G
R
G
KTV
G
DP
LT
G
HP
K
V
RM
VS
L
TGS
IA
TG
E
H
I
ISH
T
-
A
P
S
IKR
T
H
M
ELGGK
A
P
V
IV
FD
D
-
AD
-----
I
E
A
V
VEGVRTFGYY
N
A
GQ
D
C
TAAC
R
I
YAQKGIY
D
T
L
VEKLGAAVATL
K
S
G
SPDDES
-
TEL
GPL
S
S
L
AH
L
E
R
V
SKA
V
EE
A
KAT
G
H
IK
V
IT
G
G
--
EKRK
G
--
-
-
N
GY
YYA
PTL
LAGALQDDA
I
VQ
K
E
V
FGPV
V
S
V
TLFDNE
E
QV
V
NW
ANDSQYGL
A
S
S
V
W
T
K
D
V
GR
A
H
R
V
S
AR
L
Q
Y
G
CT
WVN
THFMLVSEM
P
H
GG
Q
K
L
SG
Y
G
KDM
S
LYG
L
ED
Y
TVV
R
H
V
M
V
fig|714962.3.peg.1635
Escherichia coli IHE3034 (1-472/474)
M
Q
HK
L
L
ING
ELVSG-EG
---
EKQPVY
NPAT
GDV
L
LEIAE
A
SAE
Q
V
N
A
AV
R
AA
DAA
F
--AE
W
GQTT
P
KA
R
AEC
L
L
K
LA
D
V
IE
ENGQ
V
F
A
E
LE
SR
N
C
GK
PLHSAFND
EI
PAIVDVFR
F
F
AG
AARCLN
G
LAAGEY
---
LEGHTSMI--R
R
D
PLGV
V
A
S
I
A
PWN
Y
P
LM
M
AA
WK
LA
PALAAGN
C
VV
L
KPSE
I
TPLTAL
KL
A
E
L
AK
DI
-
F
P
A
GV
I
NV
L
F
G
R
G
KTV
G
DP
LT
G
HP
K
V
RM
VS
L
TGS
IA
TG
E
H
I
ISH
T
-
A
P
S
IKR
T
H
M
ELGGK
A
P
V
IV
FD
D
-
AD
-----
I
E
A
V
VEGVRTFGYY
N
A
GQ
D
C
TAAC
R
I
YAQKGIY
D
T
L
VEKLGAAVATL
K
S
G
SPDDES
-
TEL
GPL
S
S
L
AH
L
E
R
V
SKA
V
EE
A
KAT
G
H
IK
V
IT
G
G
--
EKRK
G
--
-
-
N
GY
YYA
PTL
LAGALQDDA
I
VQ
K
E
V
FGPV
V
S
V
TLFDNE
E
QV
V
NW
ANDSQYGL
A
S
S
V
W
T
K
D
V
GR
A
H
R
V
S
AR
L
Q
Y
G
CT
WVN
THFMLVSEM
P
H
GG
Q
K
L
SG
Y
G
KDM
S
LYG
L
ED
Y
TVV
R
H
V
M
V
fig|749546.3.peg.810
Escherichia coli MS 185-1 (1-472/474)
M
Q
HK
L
L
ING
ELVSG-EG
---
EKQPVY
NPAT
GDV
L
LEIAE
A
SAE
Q
V
N
A
AV
R
AA
DAA
F
--AE
W
GQTT
P
KA
R
AEC
L
L
K
LA
D
V
IE
ENGQ
V
F
A
E
LE
SR
N
C
GK
PLHSAFND
EI
PAIVDVFR
F
F
AG
AARCLN
G
LAAGEY
---
LEGHTSMI--R
R
D
PLGV
V
A
S
I
A
PWN
Y
P
LM
M
AA
WK
LA
PALAAGN
C
VV
L
KPSE
I
TPLTAL
KL
A
E
L
AK
DI
-
F
P
A
GV
I
NV
L
F
G
R
G
KTV
G
DP
LT
G
HP
K
V
RM
VS
L
TGS
IA
TG
E
H
I
ISH
T
-
A
P
S
IKR
T
H
M
ELGGK
A
P
V
IV
FD
D
-
AD
-----
I
E
A
V
VEGVRTFGYY
N
A
GQ
D
C
TAAC
R
I
YAQKGIY
D
T
L
VEKLGAAVATL
K
S
G
SPDDES
-
TEL
GPL
S
S
L
AH
L
E
R
V
SKA
V
EE
A
KAT
G
H
IK
V
IT
G
G
--
EKRK
G
--
-
-
N
GY
YYA
PTL
LAGALQDDA
I
VQ
K
E
V
FGPV
V
S
V
TLFDNE
E
QV
V
NW
ANDSQYGL
A
S
S
V
W
T
K
D
V
GR
A
H
R
V
S
AR
L
Q
Y
G
CT
WVN
THFMLVSEM
P
H
GG
Q
K
L
SG
Y
G
KDM
S
LYG
L
ED
Y
TVV
R
H
V
M
V
fig|749550.3.peg.583
Escherichia coli MS 200-1 (1-472/474)
M
Q
HK
L
L
ING
ELVSG-EG
---
EKQPVY
NPAT
GDV
L
LEIAE
A
SAE
Q
V
N
A
AV
R
AA
DAA
F
--AE
W
GQTT
P
KA
R
AEC
L
L
K
LA
D
V
IE
ENGQ
V
F
A
E
LE
SR
N
C
GK
PLHSAFND
EI
PAIVDVFR
F
F
AG
AARCLN
G
LAAGEY
---
LEGHTSMI--R
R
D
PLGV
V
A
S
I
A
PWN
Y
P
LM
M
AA
WK
LA
PALAAGN
C
VV
L
KPSE
I
TPLTAL
KL
A
E
L
AK
DI
-
F
P
A
GV
I
NV
L
F
G
R
G
KTV
G
DP
LT
G
HP
K
V
RM
VS
L
TGS
IA
TG
E
H
I
ISH
T
-
A
P
S
IKR
T
H
M
ELGGK
A
P
V
IV
FD
D
-
AD
-----
I
E
A
V
VEGVRTFGYY
N
A
GQ
D
C
TAAC
R
I
YAQKGIY
D
T
L
VEKLGAAVATL
K
S
G
SPDDES
-
TEL
GPL
S
S
L
AH
L
E
R
V
SKA
V
EE
A
KAT
G
H
IK
V
IT
G
G
--
EKRK
G
--
-
-
N
GY
YYA
PTL
LAGALQDDA
I
VQ
K
E
V
FGPV
V
S
V
TLFDNE
E
QV
V
NW
ANDSQYGL
A
S
S
V
W
T
K
D
V
GR
A
H
R
V
S
AR
L
Q
Y
G
CT
WVN
THFMLVSEM
P
H
GG
Q
K
L
SG
Y
G
KDM
S
LYG
L
ED
Y
TVV
R
H
V
M
V
fig|749528.3.peg.1192
Escherichia coli MS 45-1 (1-472/474)
M
Q
HK
L
L
ING
ELVSG-EG
---
EKQPVY
NPAT
GDV
L
LEIAE
A
SAE
Q
V
N
A
AV
R
AA
DAA
F
--AE
W
GQTT
P
KA
R
AEC
L
L
K
LA
D
V
IE
ENGQ
V
F
A
E
LE
SR
N
C
GK
PLHSAFND
EI
PAIVDVFR
F
F
AG
AARCLN
G
LAAGEY
---
LEGHTSMI--R
R
D
PLGV
V
A
S
I
A
PWN
Y
P
LM
M
AA
WK
LA
PALAAGN
C
VV
L
KPSE
I
TPLTAL
KL
A
E
L
AK
DI
-
F
P
A
GV
I
NV
L
F
G
R
G
KTV
G
DP
LT
G
HP
K
V
RM
VS
L
TGS
IA
TG
E
H
I
ISH
T
-
A
P
S
IKR
T
H
M
ELGGK
A
P
V
IV
FD
D
-
AD
-----
I
E
A
V
VEGVRTFGYY
N
A
GQ
D
C
TAAC
R
I
YAQKGIY
D
T
L
VEKLGAAVATL
K
S
G
SPDDES
-
TEL
GPL
S
S
L
AH
L
E
R
V
SKA
V
EE
A
KAT
G
H
IK
V
IT
G
G
--
EKRK
G
--
-
-
N
GY
YYA
PTL
LAGALQDDA
I
VQ
K
E
V
FGPV
V
S
V
TLFDNE
E
QV
V
NW
ANDSQYGL
A
S
S
V
W
T
K
D
V
GR
A
H
R
V
S
AR
L
Q
Y
G
CT
WVN
THFMLVSEM
P
H
GG
Q
K
L
SG
Y
G
KDM
S
LYG
L
ED
Y
TVV
R
H
V
M
V
fig|685038.3.peg.1436
Escherichia coli O83:H1 str. NRG 857C (1-472/474)
M
Q
HK
L
L
ING
ELVSG-EG
---
EKQPVY
NPAT
GDV
L
LEIAE
A
SAE
Q
V
N
A
AV
R
AA
DAA
F
--AE
W
GQTT
P
KA
R
AEC
L
L
K
LA
D
V
IE
ENGQ
V
F
A
E
LE
SR
N
C
GK
PLHSAFND
EI
PAIVDVFR
F
F
AG
AARCLN
G
LAAGEY
---
LEGHTSMI--R
R
D
PLGV
V
A
S
I
A
PWN
Y
P
LM
M
AA
WK
LA
PALAAGN
C
VV
L
KPSE
I
TPLTAL
KL
A
E
L
AK
DI
-
F
P
A
GV
I
NV
L
F
G
R
G
KTV
G
DP
LT
G
HP
K
V
RM
VS
L
TGS
IA
TG
E
H
I
ISH
T
-
A
P
S
IKR
T
H
M
ELGGK
A
P
V
IV
FD
D
-
AD
-----
I
E
A
V
VEGVRTFGYY
N
A
GQ
D
C
TAAC
R
I
YAQKGIY
D
T
L
VEKLGAAVATL
K
S
G
SPDDES
-
TEL
GPL
S
S
L
AH
L
E
R
V
SKA
V
EE
A
KAT
G
H
IK
V
IT
G
G
--
EKRK
G
--
-
-
N
GY
YYA
PTL
LAGALQDDA
I
VQ
K
E
V
FGPV
V
S
V
TLFDNE
E
QV
V
NW
ANDSQYGL
A
S
S
V
W
T
K
D
V
GR
A
H
R
V
S
AR
L
Q
Y
G
CT
WVN
THFMLVSEM
P
H
GG
Q
K
L
SG
Y
G
KDM
S
LYG
L
ED
Y
TVV
R
H
V
M
V
fig|585035.6.peg.1527
Escherichia coli S88 (1-472/474)
M
Q
HK
L
L
ING
ELVSG-EG
---
EKQPVY
NPAT
GDV
L
LEIAE
A
SAE
Q
V
N
A
AV
R
AA
DAA
F
--AE
W
GQTT
P
KA
R
AEC
L
L
K
LA
D
V
IE
ENGQ
V
F
A
E
LE
SR
N
C
GK
PLHSAFND
EI
PAIVDVFR
F
F
AG
AARCLN
G
LAAGEY
---
LEGHTSMI--R
R
D
PLGV
V
A
S
I
A
PWN
Y
P
LM
M
AA
WK
LA
PALAAGN
C
VV
L
KPSE
I
TPLTAL
KL
A
E
L
AK
DI
-
F
P
A
GV
I
NV
L
F
G
R
G
KTV
G
DP
LT
G
HP
K
V
RM
VS
L
TGS
IA
TG
E
H
I
ISH
T
-
A
P
S
IKR
T
H
M
ELGGK
A
P
V
IV
FD
D
-
AD
-----
I
E
A
V
VEGVRTFGYY
N
A
GQ
D
C
TAAC
R
I
YAQKGIY
D
T
L
VEKLGAAVATL
K
S
G
SPDDES
-
TEL
GPL
S
S
L
AH
L
E
R
V
SKA
V
EE
A
KAT
G
H
IK
V
IT
G
G
--
EKRK
G
--
-
-
N
GY
YYA
PTL
LAGALQDDA
I
VQ
K
E
V
FGPV
V
S
V
TLFDNE
E
QV
V
NW
ANDSQYGL
A
S
S
V
W
T
K
D
V
GR
A
H
R
V
S
AR
L
Q
Y
G
CT
WVN
THFMLVSEM
P
H
GG
Q
K
L
SG
Y
G
KDM
S
LYG
L
ED
Y
TVV
R
H
V
M
V
fig|869729.3.peg.2083
Escherichia coli UM146 (1-472/474)
M
Q
HK
L
L
ING
ELVSG-EG
---
EKQPVY
NPAT
GDV
L
LEIAE
A
SAE
Q
V
N
A
AV
R
AA
DAA
F
--AE
W
GQTT
P
KA
R
AEC
L
L
K
LA
D
V
IE
ENGQ
V
F
A
E
LE
SR
N
C
GK
PLHSAFND
EI
PAIVDVFR
F
F
AG
AARCLN
G
LAAGEY
---
LEGHTSMI--R
R
D
PLGV
V
A
S
I
A
PWN
Y
P
LM
M
AA
WK
LA
PALAAGN
C
VV
L
KPSE
I
TPLTAL
KL
A
E
L
AK
DI
-
F
P
A
GV
I
NV
L
F
G
R
G
KTV
G
DP
LT
G
HP
K
V
RM
VS
L
TGS
IA
TG
E
H
I
ISH
T
-
A
P
S
IKR
T
H
M
ELGGK
A
P
V
IV
FD
D
-
AD
-----
I
E
A
V
VEGVRTFGYY
N
A
GQ
D
C
TAAC
R
I
YAQKGIY
D
T
L
VEKLGAAVATL
K
S
G
SPDDES
-
TEL
GPL
S
S
L
AH
L
E
R
V
SKA
V
EE
A
KAT
G
H
IK
V
IT
G
G
--
EKRK
G
--
-
-
N
GY
YYA
PTL
LAGALQDDA
I
VQ
K
E
V
FGPV
V
S
V
TLFDNE
E
QV
V
NW
ANDSQYGL
A
S
S
V
W
T
K
D
V
GR
A
H
R
V
S
AR
L
Q
Y
G
CT
WVN
THFMLVSEM
P
H
GG
Q
K
L
SG
Y
G
KDM
S
LYG
L
ED
Y
TVV
R
H
V
M
V
fig|364106.7.peg.1705
Escherichia coli UTI89 (1-472/474)
M
Q
HK
L
L
ING
ELVSG-EG
---
EKQPVY
NPAT
GDV
L
LEIAE
A
SAE
Q
V
N
A
AV
R
AA
DAA
F
--AE
W
GQTT
P
KA
R
AEC
L
L
K
LA
D
V
IE
ENGQ
V
F
A
E
LE
SR
N
C
GK
PLHSAFND
EI
PAIVDVFR
F
F
AG
AARCLN
G
LAAGEY
---
LEGHTSMI--R
R
D
PLGV
V
A
S
I
A
PWN
Y
P
LM
M
AA
WK
LA
PALAAGN
C
VV
L
KPSE
I
TPLTAL
KL
A
E
L
AK
DI
-
F
P
A
GV
I
NV
L
F
G
R
G
KTV
G
DP
LT
G
HP
K
V
RM
VS
L
TGS
IA
TG
E
H
I
ISH
T
-
A
P
S
IKR
T
H
M
ELGGK
A
P
V
IV
FD
D
-
AD
-----
I
E
A
V
VEGVRTFGYY
N
A
GQ
D
C
TAAC
R
I
YAQKGIY
D
T
L
VEKLGAAVATL
K
S
G
SPDDES
-
TEL
GPL
S
S
L
AH
L
E
R
V
SKA
V
EE
A
KAT
G
H
IK
V
IT
G
G
--
EKRK
G
--
-
-
N
GY
YYA
PTL
LAGALQDDA
I
VQ
K
E
V
FGPV
V
S
V
TLFDNE
E
QV
V
NW
ANDSQYGL
A
S
S
V
W
T
K
D
V
GR
A
H
R
V
S
AR
L
Q
Y
G
CT
WVN
THFMLVSEM
P
H
GG
Q
K
L
SG
Y
G
KDM
S
LYG
L
ED
Y
TVV
R
H
V
M
V
fig|364106.8.peg.1706
Escherichia coli UTI89 (1-472/474)
M
Q
HK
L
L
ING
ELVSG-EG
---
EKQPVY
NPAT
GDV
L
LEIAE
A
SAE
Q
V
N
A
AV
R
AA
DAA
F
--AE
W
GQTT
P
KA
R
AEC
L
L
K
LA
D
V
IE
ENGQ
V
F
A
E
LE
SR
N
C
GK
PLHSAFND
EI
PAIVDVFR
F
F
AG
AARCLN
G
LAAGEY
---
LEGHTSMI--R
R
D
PLGV
V
A
S
I
A
PWN
Y
P
LM
M
AA
WK
LA
PALAAGN
C
VV
L
KPSE
I
TPLTAL
KL
A
E
L
AK
DI
-
F
P
A
GV
I
NV
L
F
G
R
G
KTV
G
DP
LT
G
HP
K
V
RM
VS
L
TGS
IA
TG
E
H
I
ISH
T
-
A
P
S
IKR
T
H
M
ELGGK
A
P
V
IV
FD
D
-
AD
-----
I
E
A
V
VEGVRTFGYY
N
A
GQ
D
C
TAAC
R
I
YAQKGIY
D
T
L
VEKLGAAVATL
K
S
G
SPDDES
-
TEL
GPL
S
S
L
AH
L
E
R
V
SKA
V
EE
A
KAT
G
H
IK
V
IT
G
G
--
EKRK
G
--
-
-
N
GY
YYA
PTL
LAGALQDDA
I
VQ
K
E
V
FGPV
V
S
V
TLFDNE
E
QV
V
NW
ANDSQYGL
A
S
S
V
W
T
K
D
V
GR
A
H
R
V
S
AR
L
Q
Y
G
CT
WVN
THFMLVSEM
P
H
GG
Q
K
L
SG
Y
G
KDM
S
LYG
L
ED
Y
TVV
R
H
V
M
V
fig|562.376.peg.3060
Escherichia coli WV_060327 (1-472/474)
M
Q
HK
L
L
ING
ELVSG-EG
---
EKQPVY
NPAT
GDV
L
LEIAE
A
SAE
Q
V
N
A
AV
R
AA
DAA
F
--AE
W
GQTT
P
KA
R
AEC
L
L
K
LA
D
V
IE
ENGQ
V
F
A
E
LE
SR
N
C
GK
PLHSAFND
EI
PAIVDVFR
F
F
AG
AARCLN
G
LAAGEY
---
LEGHTSMI--R
R
D
PLGV
V
A
S
I
A
PWN
Y
P
LM
M
AA
WK
LA
PALAAGN
C
VV
L
KPSE
I
TPLTAL
KL
A
E
L
AK
DI
-
F
P
A
GV
I
NV
L
F
G
R
G
KTV
G
DP
LT
G
HP
K
V
RM
VS
L
TGS
IA
TG
E
H
I
ISH
T
-
A
P
S
IKR
T
H
M
ELGGK
A
P
V
IV
FD
D
-
AD
-----
I
E
A
V
VEGVRTFGYY
N
A
GQ
D
C
TAAC
R
I
YAQKGIY
D
T
L
VEKLGAAVATL
K
S
G
SPDDES
-
TEL
GPL
S
S
L
AH
L
E
R
V
SKA
V
EE
A
KAT
G
H
IK
V
IT
G
G
--
EKRK
G
--
-
-
N
GY
YYA
PTL
LAGALQDDA
I
VQ
K
E
V
FGPV
V
S
V
TLFDNE
E
QV
V
NW
ANDSQYGL
A
S
S
V
W
T
K
D
V
GR
A
H
R
V
S
AR
L
Q
Y
G
CT
WVN
THFMLVSEM
P
H
GG
Q
K
L
SG
Y
G
KDM
S
LYG
L
ED
Y
TVV
R
H
V
M
V
fig|216593.1.peg.252
Escherichia coli E2348/69 (1-472/474)
M
Q
HK
L
L
ING
ELVSG-EG
---
EKQPVY
NPA
M
GDV
L
LEIAE
A
SAE
Q
V
N
A
AV
R
AA
DAA
F
--AE
W
GQTT
P
KA
R
AEC
L
L
K
LA
D
V
IE
ENGQ
V
F
A
E
LE
SR
N
C
GK
PLHSAFND
EI
PAIVDVFR
F
F
AG
AARCLN
G
LAAGEY
---
LEGHTSMI--R
R
D
PLGV
V
A
S
I
A
PWN
Y
P
LM
M
AA
WK
LA
PALAAGN
C
VV
L
KPSE
I
TPLTAL
KL
A
E
L
AK
DI
-
F
P
A
GV
I
NV
L
F
G
R
G
KTV
G
DP
LT
G
HP
K
V
RM
VS
L
TGS
IA
TG
E
H
I
ISH
T
-
A
P
S
IKR
T
H
M
ELGGK
A
P
V
IV
FD
D
-
AD
-----
I
E
A
V
VEGVRTFGYY
N
A
GQ
D
C
TAAC
R
I
YAQKGIY
D
T
L
VEKLGAAVATL
K
S
G
SPDDES
-
TEL
GPL
S
S
L
AH
L
E
R
V
SKA
V
EE
A
KAT
G
H
IK
V
IT
G
G
--
EKRK
G
--
-
-
N
GY
YYA
PTL
LAGALQDDA
I
VQ
K
E
V
FGPV
V
S
V
TLFDNE
E
QV
V
NW
ANDSQYGL
A
S
S
V
W
T
K
D
V
GR
A
H
R
V
S
AR
L
Q
Y
G
CT
WVN
THFMLVSEM
P
H
GG
Q
K
L
SG
Y
G
KDM
S
LYG
L
ED
Y
TVV
R
H
V
M
V
fig|574521.7.peg.1620
Escherichia coli O127:H6 str. E2348/69 (1-472/474)
M
Q
HK
L
L
ING
ELVSG-EG
---
EKQPVY
NPA
M
GDV
L
LEIAE
A
SAE
Q
V
N
A
AV
R
AA
DAA
F
--AE
W
GQTT
P
KA
R
AEC
L
L
K
LA
D
V
IE
ENGQ
V
F
A
E
LE
SR
N
C
GK
PLHSAFND
EI
PAIVDVFR
F
F
AG
AARCLN
G
LAAGEY
---
LEGHTSMI--R
R
D
PLGV
V
A
S
I
A
PWN
Y
P
LM
M
AA
WK
LA
PALAAGN
C
VV
L
KPSE
I
TPLTAL
KL
A
E
L
AK
DI
-
F
P
A
GV
I
NV
L
F
G
R
G
KTV
G
DP
LT
G
HP
K
V
RM
VS
L
TGS
IA
TG
E
H
I
ISH
T
-
A
P
S
IKR
T
H
M
ELGGK
A
P
V
IV
FD
D
-
AD
-----
I
E
A
V
VEGVRTFGYY
N
A
GQ
D
C
TAAC
R
I
YAQKGIY
D
T
L
VEKLGAAVATL
K
S
G
SPDDES
-
TEL
GPL
S
S
L
AH
L
E
R
V
SKA
V
EE
A
KAT
G
H
IK
V
IT
G
G
--
EKRK
G
--
-
-
N
GY
YYA
PTL
LAGALQDDA
I
VQ
K
E
V
FGPV
V
S
V
TLFDNE
E
QV
V
NW
ANDSQYGL
A
S
S
V
W
T
K
D
V
GR
A
H
R
V
S
AR
L
Q
Y
G
CT
WVN
THFMLVSEM
P
H
GG
Q
K
L
SG
Y
G
KDM
S
LYG
L
ED
Y
TVV
R
H
V
M
V
fig|656408.3.peg.1576
Escherichia coli H591 (1-472/474)
M
Q
HK
L
L
ING
ELVSG-EG
---
EKQPVY
NPAT
GDV
L
LEIAE
A
SAE
Q
V
D
A
AV
R
AA
DAA
F
--AE
W
GQTT
P
KV
R
AEC
L
L
K
LA
D
V
IE
ENGQ
V
F
A
E
LE
SR
N
C
GK
PLHSAFND
EI
PAIVDVFR
F
F
AG
AARCLN
G
LAAGEY
---
LEGHTSMI--R
R
D
PLGV
V
A
S
I
A
PWN
Y
P
LM
M
AA
WK
LA
PALAAGN
C
VV
L
KPSE
I
TPLTAL
KL
A
E
L
AK
DI
-
F
P
A
GV
I
NV
L
F
G
R
G
KTV
G
DP
LT
S
HP
K
V
RM
VS
L
TGS
IA
TG
E
H
I
ISH
T
-
A
S
S
IKR
T
H
M
ELGGK
A
P
V
IV
FD
D
-
AD
-----
I
E
A
V
VEGVRTFGYY
N
A
GQ
D
C
TAAC
R
I
YAQKGIY
D
T
L
VEKLGAAVATL
K
S
G
APDDES
-
TEL
GPL
S
S
L
AH
L
E
R
V
SKA
V
EE
A
KAT
G
H
IK
V
IT
G
G
--
EKRK
G
--
-
-
N
GY
YYA
PTL
LAGALQDDA
I
VQ
K
E
V
FGPV
V
S
V
TPFDNE
E
QV
V
NW
ANDSQYGL
A
S
S
V
W
T
K
D
V
GR
A
H
R
V
S
AR
L
Q
Y
G
CT
WVN
THFMLVSEM
P
H
GG
Q
K
L
SG
Y
G
KDM
S
LYG
L
ED
Y
TVV
R
H
V
M
V
fig|585396.4.peg.1908
Escherichia coli O111:H- str. 11128 (1-472/474)
M
Q
HK
L
L
ING
ELVSG-EG
---
EKQPVY
NPAT
GEV
L
LEIAE
A
SAE
Q
V
D
A
AV
R
AA
DAA
F
--AE
W
GQTT
P
KV
R
AEC
L
L
K
LA
D
V
IE
ENGQ
V
F
A
E
LE
SR
N
C
GK
PLHSAFND
EI
PAIVDVFR
F
F
AG
AARCLN
G
LAAGEY
---
LEGHTSMI--R
R
D
PLGV
V
A
S
I
A
PWN
Y
P
LM
M
AA
WK
LA
PALAAGN
C
VV
L
KPSE
I
TPLTAL
KL
A
E
L
AK
DI
-
F
P
A
GV
I
NV
L
F
G
R
G
KTV
G
DP
LT
G
HP
K
V
RM
VS
L
TGS
IA
TG
E
H
I
ISH
T
-
A
S
S
IKR
T
H
M
ELGGK
A
P
V
IV
FD
D
-
AD
-----
I
E
A
V
VEGVRTFGYY
N
A
GQ
D
C
TAAC
R
I
YAQKGIY
D
T
L
VEKLGAAVATL
K
S
G
APDDES
-
TEL
GPL
S
S
L
AH
L
E
R
V
SKA
V
EE
A
KAT
G
H
IK
V
IT
G
G
--
EKRK
G
--
-
-
N
GY
YYA
PTL
LAGALQDDA
I
VQ
K
E
V
FGPV
V
S
V
TPFDNE
E
QV
V
NW
ANDSQYGL
A
S
S
V
W
T
K
D
V
GR
A
H
R
V
S
AR
L
Q
Y
G
CT
WVN
THFMLVSEM
P
H
GG
Q
K
L
SG
Y
G
KDM
S
LYG
L
ED
Y
TVV
R
H
V
M
V
fig|749527.3.peg.3754
Escherichia coli MS 21-1 (1-472/474)
M
Q
HK
L
L
ING
ELVSG-EG
---
EKQPVY
NPAT
GDV
L
LEIAE
A
SAE
Q
V
D
A
AV
R
AA
DAA
F
--AE
W
GQTT
P
KV
R
AEC
L
L
K
LA
D
V
IE
ENGQ
V
F
A
E
LE
SR
N
C
GK
PLHSAFND
EI
PAIVDVFR
F
F
AG
AARCLN
G
LAAGEY
---
LEGHTSMI--R
R
D
PLGV
V
A
S
I
A
PWN
Y
P
LM
M
AA
WK
LA
PALAAGN
C
VV
L
KPSE
I
TPLTAL
KL
A
E
L
AK
DI
-
F
P
A
GV
I
NV
L
F
G
R
G
KTV
G
DP
LT
G
HP
K
V
RM
VS
L
TGS
IA
TG
E
H
I
ISH
T
-
A
P
S
IKR
T
H
M
ELGGK
A
P
V
IV
FD
D
-
AD
-----
I
E
A
V
VEGVRTFGYY
N
A
GQ
D
C
TAAC
R
I
YAQKGIY
D
T
L
VEKLGAAVATL
K
S
G
APADES
-
TEL
GPL
S
S
L
AH
L
E
R
V
SKA
V
EE
A
KAT
G
H
IK
V
IT
G
G
--
EKRK
G
--
-
-
N
GY
YYA
PTL
LAGALQDDA
I
VQ
K
E
V
FGPV
V
S
V
TLFDNE
E
QV
V
NW
ANDSQYGL
A
S
S
V
W
T
K
D
V
GR
A
H
R
V
S
AR
L
Q
Y
G
CT
WVN
THFMLVSEM
P
H
GG
Q
K
L
SG
Y
G
KDM
S
LYG
L
ED
Y
TVV
R
H
V
M
V
fig|1040638.4.peg.4186
Escherichia coli O104:H4 str. LB226692 (1-472/474)
M
Q
HK
L
L
ING
ELVSG-EG
---
EKQPVY
NPAT
GDV
L
LEIAE
A
SAE
Q
V
D
A
AV
R
AA
DAA
F
--AE
W
GQTT
P
KV
R
TEC
L
L
K
LA
D
V
IE
ENGQ
V
F
A
E
LE
SR
N
C
GK
PLHSAFND
EI
PAIVDVFR
F
F
AG
AARCLN
G
LAAGEY
---
LEGHTSMI--R
R
D
PLGV
V
A
S
I
A
PWN
Y
P
LM
M
AA
WK
LA
PALAAGN
C
VV
L
KPSE
I
TPLTAL
KL
A
E
L
AK
DI
-
F
P
A
GV
I
NV
L
F
G
R
G
KTV
G
DP
LT
G
HP
K
V
RM
VS
L
TGS
IA
TG
E
H
I
ISH
T
-
A
S
S
IKR
T
H
M
ELGGK
A
P
V
IV
FD
D
-
AD
-----
I
E
A
V
VEGVRTFGYY
N
A
GQ
D
C
TAAC
R
I
YAQKGIY
D
T
L
VEKLGAAVATL
K
S
G
APDDES
-
TEL
GPL
S
S
L
AH
L
E
R
V
SKA
V
EE
A
KAT
G
H
IK
V
IT
G
G
--
EKRK
G
--
-
-
N
GY
YYA
PTL
LAGALQDDA
I
VQ
K
E
V
FGPV
V
S
V
TPFDNE
E
QV
V
NW
ANDSQYGL
A
S
S
V
W
T
K
D
V
GR
A
H
R
V
S
AR
L
Q
Y
G
CT
WVN
THFMLVSEM
P
H
GG
Q
K
L
SG
Y
G
KDM
S
LYG
L
ED
Y
TVV
R
H
V
M
V
fig|6666666.5357.peg.4846
Escherichia coli TY-2482 (1-472/474)
M
Q
HK
L
L
ING
ELVSG-EG
---
EKQPVY
NPAT
GDV
L
LEIAE
A
SAE
Q
V
D
A
AV
R
AA
DAA
F
--AE
W
GQTT
P
KV
R
TEC
L
L
K
LA
D
V
IE
ENGQ
V
F
A
E
LE
SR
N
C
GK
PLHSAFND
EI
PAIVDVFR
F
F
AG
AARCLN
G
LAAGEY
---
LEGHTSMI--R
R
D
PLGV
V
A
S
I
A
PWN
Y
P
LM
M
AA
WK
LA
PALAAGN
C
VV
L
KPSE
I
TPLTAL
KL
A
E
L
AK
DI
-
F
P
A
GV
I
NV
L
F
G
R
G
KTV
G
DP
LT
G
HP
K
V
RM
VS
L
TGS
IA
TG
E
H
I
ISH
T
-
A
S
S
IKR
T
H
M
ELGGK
A
P
V
IV
FD
D
-
AD
-----
I
E
A
V
VEGVRTFGYY
N
A
GQ
D
C
TAAC
R
I
YAQKGIY
D
T
L
VEKLGAAVATL
K
S
G
APDDES
-
TEL
GPL
S
S
L
AH
L
E
R
V
SKA
V
EE
A
KAT
G
H
IK
V
IT
G
G
--
EKRK
G
--
-
-
N
GY
YYA
PTL
LAGALQDDA
I
VQ
K
E
V
FGPV
V
S
V
TPFDNE
E
QV
V
NW
ANDSQYGL
A
S
S
V
W
T
K
D
V
GR
A
H
R
V
S
AR
L
Q
Y
G
CT
WVN
THFMLVSEM
P
H
GG
Q
K
L
SG
Y
G
KDM
S
LYG
L
ED
Y
TVV
R
H
V
M
V
fig|585055.6.peg.1604
Escherichia coli 55989 (1-472/474)
M
Q
HK
L
L
ING
ELVSG-EG
---
EKQPVY
NPAT
GDV
L
LEIAE
A
SAE
Q
V
D
A
AV
R
AA
DAA
F
--AE
W
GQTT
P
KV
R
TEC
L
L
K
LA
D
V
IE
ENGQ
V
F
A
E
LE
SR
N
C
GK
PLHSAFND
EI
PAIVDVFR
F
F
AG
AARCLN
G
LAAGEY
---
LEGHTSMI--R
R
D
PLGV
V
A
S
I
A
PWN
Y
P
LM
M
AA
WK
LA
PALAAGN
C
VV
L
KPSE
I
TPLTAL
KL
A
E
L
AK
DI
-
F
P
A
GV
I
NV
L
F
G
R
G
KTV
G
DP
LT
G
HP
K
V
RM
VS
L
TGS
IA
TG
E
H
I
ISH
T
-
A
S
S
IKR
T
H
M
ELGGK
A
P
V
IV
FD
D
-
AD
-----
I
E
A
V
VEGVRTFGYY
N
A
GQ
D
C
TAAC
R
I
YAQKGIY
D
T
L
VEKLGAAVATL
K
S
G
APDDES
-
TEL
GPL
S
S
L
AH
L
E
R
V
SKA
V
EE
A
KAT
G
H
IK
V
IT
G
G
--
EKRK
G
--
-
-
N
GY
YYA
PTL
LAGALQDDA
I
VQ
K
E
V
FGPV
V
S
V
TPFDNE
E
QV
V
NW
ANDSQYGL
A
S
S
V
W
T
K
D
V
GR
A
H
R
V
S
AR
L
Q
Y
G
CT
WVN
THFMLVSEM
P
H
GG
Q
K
L
SG
Y
G
KDM
S
LYG
L
ED
Y
TVV
R
H
V
M
V
fig|585055.8.peg.1607
Escherichia coli 55989 (1-472/474)
M
Q
HK
L
L
ING
ELVSG-EG
---
EKQPVY
NPAT
GDV
L
LEIAE
A
SAE
Q
V
D
A
AV
R
AA
DAA
F
--AE
W
GQTT
P
KV
R
TEC
L
L
K
LA
D
V
IE
ENGQ
V
F
A
E
LE
SR
N
C
GK
PLHSAFND
EI
PAIVDVFR
F
F
AG
AARCLN
G
LAAGEY
---
LEGHTSMI--R
R
D
PLGV
V
A
S
I
A
PWN
Y
P
LM
M
AA
WK
LA
PALAAGN
C
VV
L
KPSE
I
TPLTAL
KL
A
E
L
AK
DI
-
F
P
A
GV
I
NV
L
F
G
R
G
KTV
G
DP
LT
G
HP
K
V
RM
VS
L
TGS
IA
TG
E
H
I
ISH
T
-
A
S
S
IKR
T
H
M
ELGGK
A
P
V
IV
FD
D
-
AD
-----
I
E
A
V
VEGVRTFGYY
N
A
GQ
D
C
TAAC
R
I
YAQKGIY
D
T
L
VEKLGAAVATL
K
S
G
APDDES
-
TEL
GPL
S
S
L
AH
L
E
R
V
SKA
V
EE
A
KAT
G
H
IK
V
IT
G
G
--
EKRK
G
--
-
-
N
GY
YYA
PTL
LAGALQDDA
I
VQ
K
E
V
FGPV
V
S
V
TPFDNE
E
QV
V
NW
ANDSQYGL
A
S
S
V
W
T
K
D
V
GR
A
H
R
V
S
AR
L
Q
Y
G
CT
WVN
THFMLVSEM
P
H
GG
Q
K
L
SG
Y
G
KDM
S
LYG
L
ED
Y
TVV
R
H
V
M
V
fig|340185.3.peg.1074
Escherichia coli E22 (1-472/474)
M
Q
HK
L
L
ING
ELVSG-EG
---
EKQPVY
NPAT
GDV
L
LEIAE
A
SAE
Q
V
D
A
AV
R
AA
DAA
F
--AE
W
GQTT
P
KV
R
AEC
L
L
K
LA
D
V
IE
ENGQ
V
F
A
E
LE
SR
N
C
GK
PLHSAFND
EI
PAIVDVFR
F
F
AG
AARCLN
G
LAAGEY
---
LEGHTSMI--R
R
D
PLGV
V
A
S
I
A
PWN
Y
P
LM
M
AA
WK
LA
PALAAGN
C
VV
L
KPSE
I
TPLTAL
KL
A
E
L
AK
DI
-
F
P
A
GV
I
NV
L
F
G
R
G
KTV
G
DP
LT
G
HP
K
V
RM
VS
L
TGS
IA
TG
E
H
I
ISH
T
-
A
S
S
IKR
T
H
M
ELGGK
A
P
V
IV
FD
D
-
AD
-----
I
E
A
V
VEGVRTFGYY
N
A
GQ
D
C
TAAC
R
I
YAQKGIY
D
T
L
VEKLGAAVATL
K
S
G
APDDES
-
TEL
GPL
S
S
L
AH
L
E
R
V
SKA
V
EE
A
KAT
G
H
IK
V
IT
G
G
--
EKRK
G
--
-
-
N
GY
YYA
PTL
LAGALQDDA
I
VQ
K
E
V
FGPV
V
S
V
TPFDNE
E
QV
V
NW
ANDSQYGL
A
S
S
V
W
T
K
D
V
GR
A
H
R
V
S
AR
L
Q
Y
G
CT
WVN
THFMLVSEM
P
H
GG
Q
K
L
SG
Y
G
KDM
S
LYG
L
ED
Y
TVV
R
H
V
M
V
fig|340185.4.peg.1128
Escherichia coli E22 (1-472/474)
M
Q
HK
L
L
ING
ELVSG-EG
---
EKQPVY
NPAT
GDV
L
LEIAE
A
SAE
Q
V
D
A
AV
R
AA
DAA
F
--AE
W
GQTT
P
KV
R
AEC
L
L
K
LA
D
V
IE
ENGQ
V
F
A
E
LE
SR
N
C
GK
PLHSAFND
EI
PAIVDVFR
F
F
AG
AARCLN
G
LAAGEY
---
LEGHTSMI--R
R
D
PLGV
V
A
S
I
A
PWN
Y
P
LM
M
AA
WK
LA
PALAAGN
C
VV
L
KPSE
I
TPLTAL
KL
A
E
L
AK
DI
-
F
P
A
GV
I
NV
L
F
G
R
G
KTV
G
DP
LT
G
HP
K
V
RM
VS
L
TGS
IA
TG
E
H
I
ISH
T
-
A
S
S
IKR
T
H
M
ELGGK
A
P
V
IV
FD
D
-
AD
-----
I
E
A
V
VEGVRTFGYY
N
A
GQ
D
C
TAAC
R
I
YAQKGIY
D
T
L
VEKLGAAVATL
K
S
G
APDDES
-
TEL
GPL
S
S
L
AH
L
E
R
V
SKA
V
EE
A
KAT
G
H
IK
V
IT
G
G
--
EKRK
G
--
-
-
N
GY
YYA
PTL
LAGALQDDA
I
VQ
K
E
V
FGPV
V
S
V
TPFDNE
E
QV
V
NW
ANDSQYGL
A
S
S
V
W
T
K
D
V
GR
A
H
R
V
S
AR
L
Q
Y
G
CT
WVN
THFMLVSEM
P
H
GG
Q
K
L
SG
Y
G
KDM
S
LYG
L
ED
Y
TVV
R
H
V
M
V
fig|331111.12.peg.1908
Escherichia coli E24377A (1-472/474)
M
Q
HK
L
L
ING
ELVSG-EG
---
EKQPVY
NPAT
GDV
L
LEIAE
A
SAE
Q
V
D
A
AV
R
AA
DAA
F
--AE
W
GQTT
P
KV
R
AEC
L
L
K
LA
D
V
IE
ENGQ
V
F
A
E
LE
SR
N
C
GK
PLHSAFND
EI
PAIVDVFR
F
F
AG
AARCLN
G
LAAGEY
---
LEGHTSMI--R
R
D
PLGV
V
A
S
I
A
PWN
Y
P
LM
M
AA
WK
LA
PALAAGN
C
VV
L
KPSE
I
TPLTAL
KL
A
E
L
AK
DI
-
F
P
A
GV
I
NV
L
F
G
R
G
KTV
G
DP
LT
G
HP
K
V
RM
VS
L
TGS
IA
TG
E
H
I
ISH
T
-
A
S
S
IKR
T
H
M
ELGGK
A
P
V
IV
FD
D
-
AD
-----
I
E
A
V
VEGVRTFGYY
N
A
GQ
D
C
TAAC
R
I
YAQKGIY
D
T
L
VEKLGAAVATL
K
S
G
APDDES
-
TEL
GPL
S
S
L
AH
L
E
R
V
SKA
V
EE
A
KAT
G
H
IK
V
IT
G
G
--
EKRK
G
--
-
-
N
GY
YYA
PTL
LAGALQDDA
I
VQ
K
E
V
FGPV
V
S
V
TPFDNE
E
QV
V
NW
ANDSQYGL
A
S
S
V
W
T
K
D
V
GR
A
H
R
V
S
AR
L
Q
Y
G
CT
WVN
THFMLVSEM
P
H
GG
Q
K
L
SG
Y
G
KDM
S
LYG
L
ED
Y
TVV
R
H
V
M
V
fig|331111.3.peg.4068
Escherichia coli E24377A (1-472/474)
M
Q
HK
L
L
ING
ELVSG-EG
---
EKQPVY
NPAT
GDV
L
LEIAE
A
SAE
Q
V
D
A
AV
R
AA
DAA
F
--AE
W
GQTT
P
KV
R
AEC
L
L
K
LA
D
V
IE
ENGQ
V
F
A
E
LE
SR
N
C
GK
PLHSAFND
EI
PAIVDVFR
F
F
AG
AARCLN
G
LAAGEY
---
LEGHTSMI--R
R
D
PLGV
V
A
S
I
A
PWN
Y
P
LM
M
AA
WK
LA
PALAAGN
C
VV
L
KPSE
I
TPLTAL
KL
A
E
L
AK
DI
-
F
P
A
GV
I
NV
L
F
G
R
G
KTV
G
DP
LT
G
HP
K
V
RM
VS
L
TGS
IA
TG
E
H
I
ISH
T
-
A
S
S
IKR
T
H
M
ELGGK
A
P
V
IV
FD
D
-
AD
-----
I
E
A
V
VEGVRTFGYY
N
A
GQ
D
C
TAAC
R
I
YAQKGIY
D
T
L
VEKLGAAVATL
K
S
G
APDDES
-
TEL
GPL
S
S
L
AH
L
E
R
V
SKA
V
EE
A
KAT
G
H
IK
V
IT
G
G
--
EKRK
G
--
-
-
N
GY
YYA
PTL
LAGALQDDA
I
VQ
K
E
V
FGPV
V
S
V
TPFDNE
E
QV
V
NW
ANDSQYGL
A
S
S
V
W
T
K
D
V
GR
A
H
R
V
S
AR
L
Q
Y
G
CT
WVN
THFMLVSEM
P
H
GG
Q
K
L
SG
Y
G
KDM
S
LYG
L
ED
Y
TVV
R
H
V
M
V
fig|585034.4.peg.1428
Escherichia coli IAI1 (1-472/474)
M
Q
HK
L
L
ING
ELVSG-EG
---
EKQPVY
NPAT
GDV
L
LEIAE
A
SAE
Q
V
D
A
AV
R
AA
DAA
F
--AE
W
GQTT
P
KV
R
AEC
L
L
K
LA
D
V
IE
ENGQ
V
F
A
E
LE
SR
N
C
GK
PLHSAFND
EI
PAIVDVFR
F
F
AG
AARCLN
G
LAAGEY
---
LEGHTSMI--R
R
D
PLGV
V
A
S
I
A
PWN
Y
P
LM
M
AA
WK
LA
PALAAGN
C
VV
L
KPSE
I
TPLTAL
KL
A
E
L
AK
DI
-
F
P
A
GV
I
NV
L
F
G
R
G
KTV
G
DP
LT
G
HP
K
V
RM
VS
L
TGS
IA
TG
E
H
I
ISH
T
-
A
S
S
IKR
T
H
M
ELGGK
A
P
V
IV
FD
D
-
AD
-----
I
E
A
V
VEGVRTFGYY
N
A
GQ
D
C
TAAC
R
I
YAQKGIY
D
T
L
VEKLGAAVATL
K
S
G
APDDES
-
TEL
GPL
S
S
L
AH
L
E
R
V
SKA
V
EE
A
KAT
G
H
IK
V
IT
G
G
--
EKRK
G
--
-
-
N
GY
YYA
PTL
LAGALQDDA
I
VQ
K
E
V
FGPV
V
S
V
TPFDNE
E
QV
V
NW
ANDSQYGL
A
S
S
V
W
T
K
D
V
GR
A
H
R
V
S
AR
L
Q
Y
G
CT
WVN
THFMLVSEM
P
H
GG
Q
K
L
SG
Y
G
KDM
S
LYG
L
ED
Y
TVV
R
H
V
M
V
fig|585034.5.peg.1424
Escherichia coli IAI1 (1-472/474)
M
Q
HK
L
L
ING
ELVSG-EG
---
EKQPVY
NPAT
GDV
L
LEIAE
A
SAE
Q
V
D
A
AV
R
AA
DAA
F
--AE
W
GQTT
P
KV
R
AEC
L
L
K
LA
D
V
IE
ENGQ
V
F
A
E
LE
SR
N
C
GK
PLHSAFND
EI
PAIVDVFR
F
F
AG
AARCLN
G
LAAGEY
---
LEGHTSMI--R
R
D
PLGV
V
A
S
I
A
PWN
Y
P
LM
M
AA
WK
LA
PALAAGN
C
VV
L
KPSE
I
TPLTAL
KL
A
E
L
AK
DI
-
F
P
A
GV
I
NV
L
F
G
R
G
KTV
G
DP
LT
G
HP
K
V
RM
VS
L
TGS
IA
TG
E
H
I
ISH
T
-
A
S
S
IKR
T
H
M
ELGGK
A
P
V
IV
FD
D
-
AD
-----
I
E
A
V
VEGVRTFGYY
N
A
GQ
D
C
TAAC
R
I
YAQKGIY
D
T
L
VEKLGAAVATL
K
S
G
APDDES
-
TEL
GPL
S
S
L
AH
L
E
R
V
SKA
V
EE
A
KAT
G
H
IK
V
IT
G
G
--
EKRK
G
--
-
-
N
GY
YYA
PTL
LAGALQDDA
I
VQ
K
E
V
FGPV
V
S
V
TPFDNE
E
QV
V
NW
ANDSQYGL
A
S
S
V
W
T
K
D
V
GR
A
H
R
V
S
AR
L
Q
Y
G
CT
WVN
THFMLVSEM
P
H
GG
Q
K
L
SG
Y
G
KDM
S
LYG
L
ED
Y
TVV
R
H
V
M
V
fig|679207.4.peg.1342
Escherichia coli MS 107-1 (1-472/474)
M
Q
HK
L
L
ING
ELVSG-EG
---
EKQPVY
NPAT
GDV
L
LEIAE
A
SAE
Q
V
D
A
AV
R
AA
DAA
F
--AE
W
GQTT
P
KV
R
AEC
L
L
K
LA
D
V
IE
ENGQ
V
F
A
E
LE
SR
N
C
GK
PLHSAFND
EI
PAIVDVFR
F
F
AG
AARCLN
G
LAAGEY
---
LEGHTSMI--R
R
D
PLGV
V
A
S
I
A
PWN
Y
P
LM
M
AA
WK
LA
PALAAGN
C
VV
L
KPSE
I
TPLTAL
KL
A
E
L
AK
DI
-
F
P
A
GV
I
NV
L
F
G
R
G
KTV
G
DP
LT
G
HP
K
V
RM
VS
L
TGS
IA
TG
E
H
I
ISH
T
-
A
S
S
IKR
T
H
M
ELGGK
A
P
V
IV
FD
D
-
AD
-----
I
E
A
V
VEGVRTFGYY
N
A
GQ
D
C
TAAC
R
I
YAQKGIY
D
T
L
VEKLGAAVATL
K
S
G
APDDES
-
TEL
GPL
S
S
L
AH
L
E
R
V
SKA
V
EE
A
KAT
G
H
IK
V
IT
G
G
--
EKRK
G
--
-
-
N
GY
YYA
PTL
LAGALQDDA
I
VQ
K
E
V
FGPV
V
S
V
TPFDNE
E
QV
V
NW
ANDSQYGL
A
S
S
V
W
T
K
D
V
GR
A
H
R
V
S
AR
L
Q
Y
G
CT
WVN
THFMLVSEM
P
H
GG
Q
K
L
SG
Y
G
KDM
S
LYG
L
ED
Y
TVV
R
H
V
M
V
fig|679206.4.peg.3011
Escherichia coli MS 119-7 (1-472/474)
M
Q
HK
L
L
ING
ELVSG-EG
---
EKQPVY
NPAT
GDV
L
LEIAE
A
SAE
Q
V
D
A
AV
R
AA
DAA
F
--AE
W
GQTT
P
KV
R
AEC
L
L
K
LA
D
V
IE
ENGQ
V
F
A
E
LE
SR
N
C
GK
PLHSAFND
EI
PAIVDVFR
F
F
AG
AARCLN
G
LAAGEY
---
LEGHTSMI--R
R
D
PLGV
V
A
S
I
A
PWN
Y
P
LM
M
AA
WK
LA
PALAAGN
C
VV
L
KPSE
I
TPLTAL
KL
A
E
L
AK
DI
-
F
P
A
GV
I
NV
L
F
G
R
G
KTV
G
DP
LT
G
HP
K
V
RM
VS
L
TGS
IA
TG
E
H
I
ISH
T
-
A
S
S
IKR
T
H
M
ELGGK
A
P
V
IV
FD
D
-
AD
-----
I
E
A
V
VEGVRTFGYY
N
A
GQ
D
C
TAAC
R
I
YAQKGIY
D
T
L
VEKLGAAVATL
K
S
G
APDDES
-
TEL
GPL
S
S
L
AH
L
E
R
V
SKA
V
EE
A
KAT
G
H
IK
V
IT
G
G
--
EKRK
G
--
-
-
N
GY
YYA
PTL
LAGALQDDA
I
VQ
K
E
V
FGPV
V
S
V
TPFDNE
E
QV
V
NW
ANDSQYGL
A
S
S
V
W
T
K
D
V
GR
A
H
R
V
S
AR
L
Q
Y
G
CT
WVN
THFMLVSEM
P
H
GG
Q
K
L
SG
Y
G
KDM
S
LYG
L
ED
Y
TVV
R
H
V
M
V
fig|749545.3.peg.71
Escherichia coli MS 182-1 (1-472/474)
M
Q
HK
L
L
ING
ELVSG-EG
---
EKQPVY
NPAT
GDV
L
LEIAE
A
SAE
Q
V
D
A
AV
R
AA
DAA
F
--AE
W
GQTT
P
KV
R
AEC
L
L
K
LA
D
V
IE
ENGQ
V
F
A
E
LE
SR
N
C
GK
PLHSAFND
EI
PAIVDVFR
F
F
AG
AARCLN
G
LAAGEY
---
LEGHTSMI--R
R
D
PLGV
V
A
S
I
A
PWN
Y
P
LM
M
AA
WK
LA
PALAAGN
C
VV
L
KPSE
I
TPLTAL
KL
A
E
L
AK
DI
-
F
P
A
GV
I
NV
L
F
G
R
G
KTV
G
DP
LT
G
HP
K
V
RM
VS
L
TGS
IA
TG
E
H
I
ISH
T
-
A
S
S
IKR
T
H
M
ELGGK
A
P
V
IV
FD
D
-
AD
-----
I
E
A
V
VEGVRTFGYY
N
A
GQ
D
C
TAAC
R
I
YAQKGIY
D
T
L
VEKLGAAVATL
K
S
G
APDDES
-
TEL
GPL
S
S
L
AH
L
E
R
V
SKA
V
EE
A
KAT
G
H
IK
V
IT
G
G
--
EKRK
G
--
-
-
N
GY
YYA
PTL
LAGALQDDA
I
VQ
K
E
V
FGPV
V
S
V
TPFDNE
E
QV
V
NW
ANDSQYGL
A
S
S
V
W
T
K
D
V
GR
A
H
R
V
S
AR
L
Q
Y
G
CT
WVN
THFMLVSEM
P
H
GG
Q
K
L
SG
Y
G
KDM
S
LYG
L
ED
Y
TVV
R
H
V
M
V
fig|749532.3.peg.979
Escherichia coli MS 78-1 (1-472/474)
M
Q
HK
L
L
ING
ELVSG-EG
---
EKQPVY
NPAT
GDV
L
LEIAE
A
SAE
Q
V
D
A
AV
R
AA
DAA
F
--AE
W
GQTT
P
KV
R
AEC
L
L
K
LA
D
V
IE
ENGQ
V
F
A
E
LE
SR
N
C
GK
PLHSAFND
EI
PAIVDVFR
F
F
AG
AARCLN
G
LAAGEY
---
LEGHTSMI--R
R
D
PLGV
V
A
S
I
A
PWN
Y
P
LM
M
AA
WK
LA
PALAAGN
C
VV
L
KPSE
I
TPLTAL
KL
A
E
L
AK
DI
-
F
P
A
GV
I
NV
L
F
G
R
G
KTV
G
DP
LT
G
HP
K
V
RM
VS
L
TGS
IA
TG
E
H
I
ISH
T
-
A
S
S
IKR
T
H
M
ELGGK
A
P
V
IV
FD
D
-
AD
-----
I
E
A
V
VEGVRTFGYY
N
A
GQ
D
C
TAAC
R
I
YAQKGIY
D
T
L
VEKLGAAVATL
K
S
G
APDDES
-
TEL
GPL
S
S
L
AH
L
E
R
V
SKA
V
EE
A
KAT
G
H
IK
V
IT
G
G
--
EKRK
G
--
-
-
N
GY
YYA
PTL
LAGALQDDA
I
VQ
K
E
V
FGPV
V
S
V
TPFDNE
E
QV
V
NW
ANDSQYGL
A
S
S
V
W
T
K
D
V
GR
A
H
R
V
S
AR
L
Q
Y
G
CT
WVN
THFMLVSEM
P
H
GG
Q
K
L
SG
Y
G
KDM
S
LYG
L
ED
Y
TVV
R
H
V
M
V
fig|585395.4.peg.1650
Escherichia coli O103:H2 str. 12009 (1-472/474)
M
Q
HK
L
L
ING
ELVSG-EG
---
EKQPVY
NPAT
GDV
L
LEIAE
A
SAE
Q
V
D
A
AV
R
AA
DAA
F
--AE
W
GQTT
P
KV
R
AEC
L
L
K
LA
D
V
IE
ENGQ
V
F
A
E
LE
SR
N
C
GK
PLHSAFND
EI
PAIVDVFR
F
F
AG
AARCLN
G
LAAGEY
---
LEGHTSMI--R
R
D
PLGV
V
A
S
I
A
PWN
Y
P
LM
M
AA
WK
LA
PALAAGN
C
VV
L
KPSE
I
TPLTAL
KL
A
E
L
AK
DI
-
F
P
A
GV
I
NV
L
F
G
R
G
KTV
G
DP
LT
G
HP
K
V
RM
VS
L
TGS
IA
TG
E
H
I
ISH
T
-
A
S
S
IKR
T
H
M
ELGGK
A
P
V
IV
FD
D
-
AD
-----
I
E
A
V
VEGVRTFGYY
N
A
GQ
D
C
TAAC
R
I
YAQKGIY
D
T
L
VEKLGAAVATL
K
S
G
APDDES
-
TEL
GPL
S
S
L
AH
L
E
R
V
SKA
V
EE
A
KAT
G
H
IK
V
IT
G
G
--
EKRK
G
--
-
-
N
GY
YYA
PTL
LAGALQDDA
I
VQ
K
E
V
FGPV
V
S
V
TPFDNE
E
QV
V
NW
ANDSQYGL
A
S
S
V
W
T
K
D
V
GR
A
H
R
V
S
AR
L
Q
Y
G
CT
WVN
THFMLVSEM
P
H
GG
Q
K
L
SG
Y
G
KDM
S
LYG
L
ED
Y
TVV
R
H
V
M
V
fig|573235.3.peg.2077
Escherichia coli O26:H11 str. 11368 (1-472/474)
M
Q
HK
L
L
ING
ELVSG-EG
---
EKQPVY
NPAT
GDV
L
LEIAE
A
SAE
Q
V
D
A
AV
R
AA
DAA
F
--AE
W
GQTT
P
KV
R
AEC
L
L
K
LA
D
V
IE
ENGQ
V
F
A
E
LE
SR
N
C
GK
PLHSAFND
EI
PAIVDVFR
F
F
AG
AARCLN
G
LAAGEY
---
LEGHTSMI--R
R
D
PLGV
V
A
S
I
A
PWN
Y
P
LM
M
AA
WK
LA
PALAAGN
C
VV
L
KPSE
I
TPLTAL
KL
A
E
L
AK
DI
-
F
P
A
GV
I
NV
L
F
G
R
G
KTV
G
DP
LT
G
HP
K
V
RM
VS
L
TGS
IA
TG
E
H
I
ISH
T
-
A
S
S
IKR
T
H
M
ELGGK
A
P
V
IV
FD
D
-
AD
-----
I
E
A
V
VEGVRTFGYY
N
A
GQ
D
C
TAAC
R
I
YAQKGIY
D
T
L
VEKLGAAVATL
K
S
G
APDDES
-
TEL
GPL
S
S
L
AH
L
E
R
V
SKA
V
EE
A
KAT
G
H
IK
V
IT
G
G
--
EKRK
G
--
-
-
N
GY
YYA
PTL
LAGALQDDA
I
VQ
K
E
V
FGPV
V
S
V
TPFDNE
E
QV
V
NW
ANDSQYGL
A
S
S
V
W
T
K
D
V
GR
A
H
R
V
S
AR
L
Q
Y
G
CT
WVN
THFMLVSEM
P
H
GG
Q
K
L
SG
Y
G
KDM
S
LYG
L
ED
Y
TVV
R
H
V
M
V
fig|409438.11.peg.1669
Escherichia coli SE11 (1-472/474)
M
Q
HK
L
L
ING
ELVSG-EG
---
EKQPVY
NPAT
GDV
L
LEIAE
A
SAE
Q
V
D
A
AV
R
AA
DAA
F
--AE
W
GQTT
P
KV
R
AEC
L
L
K
LA
D
V
IE
ENGQ
V
F
A
E
LE
SR
N
C
GK
PLHSAFND
EI
PAIVDVFR
F
F
AG
AARCLN
G
LAAGEY
---
LEGHTSMI--R
R
D
PLGV
V
A
S
I
A
PWN
Y
P
LM
M
AA
WK
LA
PALAAGN
C
VV
L
KPSE
I
TPLTAL
KL
A
E
L
AK
DI
-
F
P
A
GV
I
NV
L
F
G
R
G
KTV
G
DP
LT
G
HP
K
V
RM
VS
L
TGS
IA
TG
E
H
I
ISH
T
-
A
S
S
IKR
T
H
M
ELGGK
A
P
V
IV
FD
D
-
AD
-----
I
E
A
V
VEGVRTFGYY
N
A
GQ
D
C
TAAC
R
I
YAQKGIY
D
T
L
VEKLGAAVATL
K
S
G
APDDES
-
TEL
GPL
S
S
L
AH
L
E
R
V
SKA
V
EE
A
KAT
G
H
IK
V
IT
G
G
--
EKRK
G
--
-
-
N
GY
YYA
PTL
LAGALQDDA
I
VQ
K
E
V
FGPV
V
S
V
TPFDNE
E
QV
V
NW
ANDSQYGL
A
S
S
V
W
T
K
D
V
GR
A
H
R
V
S
AR
L
Q
Y
G
CT
WVN
THFMLVSEM
P
H
GG
Q
K
L
SG
Y
G
KDM
S
LYG
L
ED
Y
TVV
R
H
V
M
V
fig|656443.3.peg.1774
Escherichia coli TA271 (1-472/474)
M
Q
HK
L
L
ING
ELVSG-EG
---
EKQPVY
NPAT
GDV
L
LEIAE
A
SAE
Q
V
D
A
AV
R
AA
DAA
F
--AE
W
GQTT
P
KV
R
AEC
L
L
K
LA
D
V
IE
ENGQ
V
F
A
E
LE
SR
N
C
GK
PLHSAFND
EI
PAIVDVFR
F
F
AG
AARCLN
G
LAAGEY
---
LEGHTSMI--R
R
D
PLGV
V
A
S
I
A
PWN
Y
P
LM
M
AA
WK
LA
PALAAGN
C
VV
L
KPSE
I
TPLTAL
KL
A
E
L
AK
DI
-
F
P
A
GV
I
NV
L
F
G
R
G
KTV
G
DP
LT
G
HP
K
V
RM
VS
L
TGS
IA
TG
E
H
I
ISH
T
-
A
S
S
IKR
T
H
M
ELGGK
A
P
V
IV
FD
D
-
AD
-----
I
E
A
V
VEGVRTFGYY
N
A
GQ
D
C
TAAC
R
I
YAQKGIY
D
T
L
VEKLGAAVATL
K
S
G
APDDES
-
TEL
GPL
S
S
L
AH
L
E
R
V
SKA
V
EE
A
KAT
G
H
IK
V
IT
G
G
--
EKRK
G
--
-
-
N
GY
YYA
PTL
LAGALQDDA
I
VQ
K
E
V
FGPV
V
S
V
TPFDNE
E
QV
V
NW
ANDSQYGL
A
S
S
V
W
T
K
D
V
GR
A
H
R
V
S
AR
L
Q
Y
G
CT
WVN
THFMLVSEM
P
H
GG
Q
K
L
SG
Y
G
KDM
S
LYG
L
ED
Y
TVV
R
H
V
M
V
fig|340184.3.peg.121
Escherichia coli B7A (1-472/474)
M
Q
HK
L
L
ING
ELVSG-EG
---
EKQPVY
NPAT
GDV
L
LEIAE
A
SAE
Q
V
D
A
AV
R
AA
DAA
F
--AE
W
GQTT
P
KV
R
AEC
L
L
K
LA
D
V
IE
ENGQ
V
F
A
E
LE
SR
N
C
GK
PLHSAFND
EI
PAIVDVFR
F
F
AG
AARCLN
G
LAAGEY
---
LEGHTSMI--R
R
D
PLGV
V
A
S
I
A
PWN
Y
P
LM
M
AA
WK
LA
PALAAGN
C
VV
L
KPSE
I
TPLTAL
KL
A
E
L
AK
DI
-
F
P
A
GV
I
NV
L
F
G
R
G
KTV
G
DP
LT
G
HP
K
V
RM
VS
L
TGS
IA
TG
E
H
I
ISH
T
-
A
S
S
IKR
T
H
M
ELGGK
A
P
V
IV
FD
D
-
AD
-----
I
E
A
V
VEGVRTFGYY
N
A
GQ
D
C
TAAC
R
I
YAQKGIY
D
T
L
VEKLGAAVATL
K
S
G
APDDES
-
TEL
GPL
S
S
L
AH
L
E
R
V
SKA
V
EE
A
KAT
G
H
IK
V
IT
G
G
--
EKRK
G
--
-
-
N
GY
YYA
PTL
LAGALQDDA
I
VQ
K
E
V
FGPV
V
S
V
TLFDNE
E
QV
V
NW
ANDSQYGL
A
S
S
V
W
T
K
D
V
GR
A
H
R
V
S
AR
L
Q
Y
G
CT
WVN
THFMLVSEM
P
H
GG
Q
K
L
SG
Y
G
KDM
S
LYG
L
ED
Y
TVV
R
H
V
M
V
fig|340184.6.peg.126
Escherichia coli B7A (1-472/474)
M
Q
HK
L
L
ING
ELVSG-EG
---
EKQPVY
NPAT
GDV
L
LEIAE
A
SAE
Q
V
D
A
AV
R
AA
DAA
F
--AE
W
GQTT
P
KV
R
AEC
L
L
K
LA
D
V
IE
ENGQ
V
F
A
E
LE
SR
N
C
GK
PLHSAFND
EI
PAIVDVFR
F
F
AG
AARCLN
G
LAAGEY
---
LEGHTSMI--R
R
D
PLGV
V
A
S
I
A
PWN
Y
P
LM
M
AA
WK
LA
PALAAGN
C
VV
L
KPSE
I
TPLTAL
KL
A
E
L
AK
DI
-
F
P
A
GV
I
NV
L
F
G
R
G
KTV
G
DP
LT
G
HP
K
V
RM
VS
L
TGS
IA
TG
E
H
I
ISH
T
-
A
S
S
IKR
T
H
M
ELGGK
A
P
V
IV
FD
D
-
AD
-----
I
E
A
V
VEGVRTFGYY
N
A
GQ
D
C
TAAC
R
I
YAQKGIY
D
T
L
VEKLGAAVATL
K
S
G
APDDES
-
TEL
GPL
S
S
L
AH
L
E
R
V
SKA
V
EE
A
KAT
G
H
IK
V
IT
G
G
--
EKRK
G
--
-
-
N
GY
YYA
PTL
LAGALQDDA
I
VQ
K
E
V
FGPV
V
S
V
TLFDNE
E
QV
V
NW
ANDSQYGL
A
S
S
V
W
T
K
D
V
GR
A
H
R
V
S
AR
L
Q
Y
G
CT
WVN
THFMLVSEM
P
H
GG
Q
K
L
SG
Y
G
KDM
S
LYG
L
ED
Y
TVV
R
H
V
M
V
fig|679204.3.peg.1306
Escherichia coli MS 145-7 (1-472/474)
M
Q
HK
L
L
ING
ELVSG-EG
---
EKQPVY
NPAT
GDV
L
LEIAE
A
SAE
Q
V
D
A
AV
R
AA
DAA
F
--AE
W
GQTT
P
KV
R
AEC
L
L
K
LA
D
V
IE
ENGQ
V
F
A
E
LE
SR
N
C
GK
PLHSAFND
EI
PAIVDVFR
F
F
AG
AARCLN
G
LAAGEY
---
LEGHTSMI--R
R
D
PLGV
V
A
S
I
A
PWN
Y
P
LM
M
AA
WK
LA
PALAAGN
C
VV
L
KPSE
I
TPLTAL
KL
A
E
L
AK
DI
-
F
P
A
GV
I
NV
L
F
G
R
G
KTV
G
DP
LT
G
HP
K
V
RM
VS
L
TGS
IA
TG
E
H
I
ISH
T
-
A
S
S
IKR
T
H
M
ELGGK
A
P
V
IV
FD
D
-
AD
-----
I
E
A
V
VEGVRTFGYY
N
A
GQ
D
C
TAAC
R
I
YAQKGIY
D
T
L
VEKLGAAVATL
K
S
G
APDDES
-
TEL
GPL
S
S
L
AH
L
E
R
V
SKA
V
EE
A
KAT
G
H
IK
V
IT
G
G
--
EKRK
G
--
-
-
N
GY
YYA
PTL
LAGALQDDA
I
VQ
K
E
V
FGPV
V
S
V
TLFDNE
E
QV
V
NW
ANDSQYGL
A
S
S
V
W
T
K
D
V
GR
A
H
R
V
S
AR
L
Q
Y
G
CT
WVN
THFMLVSEM
P
H
GG
Q
K
L
SG
Y
G
KDM
S
LYG
L
ED
Y
TVV
R
H
V
M
V
fig|749533.3.peg.72
Escherichia coli MS 84-1 (1-472/474)
M
Q
HK
L
L
ING
ELVSG-EG
---
EKQPVY
NPAT
GDV
L
LEIAE
A
SAE
Q
V
D
A
AV
R
AA
DAA
F
--AE
W
GQTT
P
KV
R
AEC
L
L
K
LA
D
V
IE
ENGQ
V
F
A
E
LE
SR
N
C
GK
PLHSAFND
EI
PAIVDVFR
F
F
AG
AARCLN
G
LAAGEY
---
LEGHTSMI--R
R
D
PLGV
V
A
S
I
A
PWN
Y
P
LM
M
AA
WK
LA
PALAAGN
C
VV
L
KPSE
I
TPLTAL
KL
A
E
L
AK
DI
-
F
P
A
GV
I
NV
L
F
G
R
G
KTV
G
DP
LT
G
HP
K
V
RM
VS
L
TGS
IA
TG
E
H
I
ISH
T
-
A
S
S
IKR
T
H
M
ELGGK
A
P
V
IV
FD
D
-
AD
-----
I
E
A
V
VEGVRTFGYY
N
A
GQ
D
C
TAAC
R
I
YAQKGIY
D
T
L
VEKLGAAVATL
K
S
G
APDDES
-
TEL
GPL
S
S
L
AH
L
E
R
V
SKA
V
EE
A
KAT
G
H
IK
V
IT
G
G
--
EKRK
G
--
-
-
N
GY
YYA
PTL
LAGALQDDA
I
VQ
K
E
V
FGPV
V
S
V
TLFDNE
E
QV
V
NW
ANDSQYGL
A
S
S
V
W
T
K
D
V
GR
A
H
R
V
S
AR
L
Q
Y
G
CT
WVN
THFMLVSEM
P
H
GG
Q
K
L
SG
Y
G
KDM
S
LYG
L
ED
Y
TVV
R
H
V
M
V
fig|566546.3.peg.18
Escherichia coli W (1-472/474)
M
Q
HK
L
L
ING
ELVSG-EG
---
EKQPVY
NPAT
GDV
L
LEIAE
A
SAE
Q
V
D
A
AV
R
AA
DAA
F
--AE
W
GQTT
P
KV
R
AEC
L
L
K
LA
D
V
IE
ENGQ
V
F
A
E
LE
SR
N
C
GK
PLHSAFND
EI
PAIVDVFR
F
F
AG
AARCLN
G
LAAGEY
---
LEGHTSMI--R
R
D
PLGV
V
A
S
I
A
PWN
Y
P
LM
M
AA
WK
LA
PALAAGN
C
VV
L
KPSE
I
TPLTAL
KL
A
E
L
AK
DI
-
F
P
A
GV
I
NV
L
F
G
R
G
KTV
G
DP
LT
G
HP
K
V
RM
VS
L
TGS
IA
TG
E
H
I
ISH
T
-
A
S
S
IKR
T
H
M
ELGGK
A
P
V
IV
FD
D
-
AD
-----
I
E
A
V
VEGVRTFGYY
N
A
GQ
D
C
TAAC
R
I
YAQKGIY
D
T
L
VEKLGAAVATL
K
S
G
APDDES
-
TEL
GPL
S
S
L
AH
L
E
R
V
SKA
V
EE
A
KAT
G
H
IK
V
IT
G
G
--
EKRK
G
--
-
-
N
GY
YYA
PTL
LAGALQDDA
I
VQ
K
E
V
FGPV
V
S
V
TLFDNE
E
QV
V
NW
ANDSQYGL
A
S
S
V
W
T
K
D
V
GR
A
H
R
V
S
AR
L
Q
Y
G
CT
WVN
THFMLVSEM
P
H
GG
Q
K
L
SG
Y
G
KDM
S
LYG
L
ED
Y
TVV
R
H
V
M
V
fig|566546.4.peg.1561
Escherichia coli W (1-472/474)
M
Q
HK
L
L
ING
ELVSG-EG
---
EKQPVY
NPAT
GDV
L
LEIAE
A
SAE
Q
V
D
A
AV
R
AA
DAA
F
--AE
W
GQTT
P
KV
R
AEC
L
L
K
LA
D
V
IE
ENGQ
V
F
A
E
LE
SR
N
C
GK
PLHSAFND
EI
PAIVDVFR
F
F
AG
AARCLN
G
LAAGEY
---
LEGHTSMI--R
R
D
PLGV
V
A
S
I
A
PWN
Y
P
LM
M
AA
WK
LA
PALAAGN
C
VV
L
KPSE
I
TPLTAL
KL
A
E
L
AK
DI
-
F
P
A
GV
I
NV
L
F
G
R
G
KTV
G
DP
LT
G
HP
K
V
RM
VS
L
TGS
IA
TG
E
H
I
ISH
T
-
A
S
S
IKR
T
H
M
ELGGK
A
P
V
IV
FD
D
-
AD
-----
I
E
A
V
VEGVRTFGYY
N
A
GQ
D
C
TAAC
R
I
YAQKGIY
D
T
L
VEKLGAAVATL
K
S
G
APDDES
-
TEL
GPL
S
S
L
AH
L
E
R
V
SKA
V
EE
A
KAT
G
H
IK
V
IT
G
G
--
EKRK
G
--
-
-
N
GY
YYA
PTL
LAGALQDDA
I
VQ
K
E
V
FGPV
V
S
V
TLFDNE
E
QV
V
NW
ANDSQYGL
A
S
S
V
W
T
K
D
V
GR
A
H
R
V
S
AR
L
Q
Y
G
CT
WVN
THFMLVSEM
P
H
GG
Q
K
L
SG
Y
G
KDM
S
LYG
L
ED
Y
TVV
R
H
V
M
V
fig|439855.10.peg.1884
Escherichia coli SMS-3-5 (1-472/474)
M
Q
HK
L
L
ING
ELVSG-EG
---
EKQPVY
NPAT
GDV
L
LEIAE
A
SAE
Q
V
D
A
AV
R
AA
DAA
F
--AE
W
GQTT
P
KA
R
AEC
L
L
K
LA
D
V
IE
ENGQ
V
F
A
E
LE
SR
N
C
GK
PLHSAFND
EI
PAIVDVFR
F
F
AG
AARCLN
G
LAAGEY
---
LEGHTSMI--R
R
D
PLGV
V
A
S
I
A
PWN
Y
P
LM
M
AA
WK
LA
PALAAGN
C
VV
L
KPSE
I
TPLTAL
KL
A
E
L
AK
DI
-
F
P
A
GV
I
NV
L
F
G
R
G
KTV
G
DP
LT
G
HP
K
V
RM
VS
L
TGS
IA
TG
E
H
I
ISH
T
-
A
P
S
IKR
T
H
M
ELGGK
A
P
V
IV
FD
D
-
AD
-----
I
E
A
V
VEGVRTFGYY
N
A
GQ
D
C
TAAC
R
I
YAQKGIY
D
T
L
VEKLGAAVATL
K
S
G
APDDDS
-
TEL
GPL
S
S
L
AH
L
E
R
V
SKA
V
EE
A
KAT
G
H
IK
V
IT
G
G
--
EKRK
G
--
-
-
N
GY
YYA
PTL
LAGALQDDA
I
VQ
K
E
V
FGPV
V
S
V
TLFDNE
E
QV
V
NW
ANDSQYGL
A
S
S
V
W
T
K
D
V
GR
A
H
R
V
S
AR
L
Q
Y
G
CT
WVN
THFMLVSEM
P
H
GG
Q
K
L
SG
Y
G
KDM
S
LYG
L
ED
Y
TVV
R
H
V
M
V
fig|316401.4.peg.1739
Escherichia coli ETEC H10407 (1-472/474)
M
Q
HK
L
L
ING
ELVSG-EG
---
EKQPVY
NPAT
GDV
L
LEIAE
A
SAE
Q
V
D
A
AV
R
AA
DAA
F
--AE
W
GQTT
P
KV
R
AEC
L
L
K
LA
D
V
IE
ENGQ
V
F
A
E
LE
SR
N
C
GK
PLHSAFND
EI
PAIVDVFR
F
F
AG
AARCLN
G
LAAGEY
---
LEGHTSMI--R
R
D
PLGV
V
A
S
I
A
PWN
Y
P
LM
M
AA
WK
LA
PALAAGN
C
VV
L
KPSE
I
TPLTAL
KL
A
E
L
AK
DI
-
F
P
A
GV
I
N
I
L
F
G
R
G
KTV
G
DP
LT
G
HP
K
V
RM
VS
L
TGS
IA
TG
E
H
I
ISH
T
-
A
S
S
IKR
T
H
M
ELGGK
A
P
V
IV
FD
D
-
AD
-----
I
E
A
V
VEGVRTFGYY
N
A
GQ
D
C
TAAC
R
I
YAQKGIY
D
T
L
VEKLGAAVATL
K
S
G
APDDES
-
TEL
GPL
S
S
L
AH
L
E
R
V
SKT
V
EE
A
KAT
G
H
IK
V
IT
G
G
--
EKRK
G
--
-
-
N
GY
YYA
PTL
LAGALQDDA
I
VQ
K
E
V
FGPV
V
S
V
TPFDNE
E
QV
V
NW
ANDSQYGL
A
S
S
V
W
T
K
D
V
GR
A
H
R
V
S
AR
L
Q
Y
G
CT
WVN
THFMLVSEM
P
H
GG
Q
K
L
SG
Y
G
KDM
S
LYG
L
ED
Y
TVV
R
H
V
M
V
fig|358709.5.peg.934
Escherichia coli 101-1 (1-472/474)
M
Q
HK
L
L
ING
ELVSG-EG
---
EKQPVY
NPAT
GDV
L
LEIAE
A
SAE
Q
V
D
A
AV
R
AA
DAA
F
--AE
W
GQTT
P
KV
R
AEC
L
L
K
LA
D
V
IE
ENGQ
V
F
A
E
LE
SR
N
C
GK
PLHSAFND
EI
PAIVDVFR
F
F
AG
AARCLN
G
LAAGEY
---
LEGHTSMI--R
R
D
PLGV
V
A
S
I
A
PWN
Y
P
LM
M
AA
WK
LA
PALAAGN
C
VV
L
KPSE
I
TPLTAL
KL
A
E
L
AK
DI
-
F
P
A
GV
I
N
I
L
F
G
R
G
KTV
G
DP
LT
G
HP
K
V
RM
VS
L
TGS
IA
TG
E
H
I
ISH
T
-
A
S
S
IKR
T
H
M
ELGGK
A
P
V
IV
FD
D
-
AD
-----
I
E
A
V
VEGVRTFGYY
N
A
GQ
D
C
TAAC
R
I
YAQKGIY
D
T
L
VEKLGAAVATL
K
S
G
APDDES
-
TEL
GPL
S
S
L
AH
L
E
R
V
SKA
V
EE
A
KAT
G
H
IK
V
IT
G
G
--
EKRK
G
--
-
-
N
GY
YYA
PTL
LAGALQDDA
I
VQ
K
E
V
FGPV
V
S
V
TPFDNE
E
QV
V
NW
ANDSQYGL
A
S
S
V
W
T
K
D
V
GR
A
H
R
V
S
AR
L
Q
Y
G
CT
WVN
THFMLVSEM
P
H
GG
Q
K
L
SG
Y
G
KDM
S
LYG
L
ED
Y
TVV
R
H
V
M
V
fig|670888.3.peg.2112
Escherichia coli 1827-70 (1-472/474)
M
Q
HK
L
L
ING
ELVSG-EG
---
EKQPVY
NPAT
GDV
L
LEIAE
A
SAE
Q
V
D
A
AV
R
AA
DAA
F
--AE
W
GQTT
P
KV
R
AEC
L
L
K
LA
D
V
IE
ENGQ
V
F
A
E
LE
SR
N
C
GK
PLHSAFND
EI
PAIVDVFR
F
F
AG
AARCLN
G
LAAGEY
---
LEGHTSMI--R
R
D
PLGV
V
A
S
I
A
PWN
Y
P
LM
M
AA
WK
LA
PALAAGN
C
VV
L
KPSE
I
TPLTAL
KL
A
E
L
AK
DI
-
F
P
A
GV
I
N
I
L
F
G
R
G
KTV
G
DP
LT
G
HP
K
V
RM
VS
L
TGS
IA
TG
E
H
I
ISH
T
-
A
S
S
IKR
T
H
M
ELGGK
A
P
V
IV
FD
D
-
AD
-----
I
E
A
V
VEGVRTFGYY
N
A
GQ
D
C
TAAC
R
I
YAQKGIY
D
T
L
VEKLGAAVATL
K
S
G
APDDES
-
TEL
GPL
S
S
L
AH
L
E
R
V
SKA
V
EE
A
KAT
G
H
IK
V
IT
G
G
--
EKRK
G
--
-
-
N
GY
YYA
PTL
LAGALQDDA
I
VQ
K
E
V
FGPV
V
S
V
TPFDNE
E
QV
V
NW
ANDSQYGL
A
S
S
V
W
T
K
D
V
GR
A
H
R
V
S
AR
L
Q
Y
G
CT
WVN
THFMLVSEM
P
H
GG
Q
K
L
SG
Y
G
KDM
S
LYG
L
ED
Y
TVV
R
H
V
M
V
fig|413997.3.peg.1474
Escherichia coli B str. REL606 (1-472/474)
M
Q
HK
L
L
ING
ELVSG-EG
---
EKQPVY
NPAT
GDV
L
LEIAE
A
SAE
Q
V
D
A
AV
R
AA
DAA
F
--AE
W
GQTT
P
KV
R
AEC
L
L
K
LA
D
V
IE
ENGQ
V
F
A
E
LE
SR
N
C
GK
PLHSAFND
EI
PAIVDVFR
F
F
AG
AARCLN
G
LAAGEY
---
LEGHTSMI--R
R
D
PLGV
V
A
S
I
A
PWN
Y
P
LM
M
AA
WK
LA
PALAAGN
C
VV
L
KPSE
I
TPLTAL
KL
A
E
L
AK
DI
-
F
P
A
GV
I
N
I
L
F
G
R
G
KTV
G
DP
LT
G
HP
K
V
RM
VS
L
TGS
IA
TG
E
H
I
ISH
T
-
A
S
S
IKR
T
H
M
ELGGK
A
P
V
IV
FD
D
-
AD
-----
I
E
A
V
VEGVRTFGYY
N
A
GQ
D
C
TAAC
R
I
YAQKGIY
D
T
L
VEKLGAAVATL
K
S
G
APDDES
-
TEL
GPL
S
S
L
AH
L
E
R
V
SKA
V
EE
A
KAT
G
H
IK
V
IT
G
G
--
EKRK
G
--
-
-
N
GY
YYA
PTL
LAGALQDDA
I
VQ
K
E
V
FGPV
V
S
V
TPFDNE
E
QV
V
NW
ANDSQYGL
A
S
S
V
W
T
K
D
V
GR
A
H
R
V
S
AR
L
Q
Y
G
CT
WVN
THFMLVSEM
P
H
GG
Q
K
L
SG
Y
G
KDM
S
LYG
L
ED
Y
TVV
R
H
V
M
V
fig|511693.5.peg.1513
Escherichia coli BL21 (1-472/474)
M
Q
HK
L
L
ING
ELVSG-EG
---
EKQPVY
NPAT
GDV
L
LEIAE
A
SAE
Q
V
D
A
AV
R
AA
DAA
F
--AE
W
GQTT
P
KV
R
AEC
L
L
K
LA
D
V
IE
ENGQ
V
F
A
E
LE
SR
N
C
GK
PLHSAFND
EI
PAIVDVFR
F
F
AG
AARCLN
G
LAAGEY
---
LEGHTSMI--R
R
D
PLGV
V
A
S
I
A
PWN
Y
P
LM
M
AA
WK
LA
PALAAGN
C
VV
L
KPSE
I
TPLTAL
KL
A
E
L
AK
DI
-
F
P
A
GV
I
N
I
L
F
G
R
G
KTV
G
DP
LT
G
HP
K
V
RM
VS
L
TGS
IA
TG
E
H
I
ISH
T
-
A
S
S
IKR
T
H
M
ELGGK
A
P
V
IV
FD
D
-
AD
-----
I
E
A
V
VEGVRTFGYY
N
A
GQ
D
C
TAAC
R
I
YAQKGIY
D
T
L
VEKLGAAVATL
K
S
G
APDDES
-
TEL
GPL
S
S
L
AH
L
E
R
V
SKA
V
EE
A
KAT
G
H
IK
V
IT
G
G
--
EKRK
G
--
-
-
N
GY
YYA
PTL
LAGALQDDA
I
VQ
K
E
V
FGPV
V
S
V
TPFDNE
E
QV
V
NW
ANDSQYGL
A
S
S
V
W
T
K
D
V
GR
A
H
R
V
S
AR
L
Q
Y
G
CT
WVN
THFMLVSEM
P
H
GG
Q
K
L
SG
Y
G
KDM
S
LYG
L
ED
Y
TVV
R
H
V
M
V
fig|469008.4.peg.2261
Escherichia coli BL21(DE3) (1-472/474)
M
Q
HK
L
L
ING
ELVSG-EG
---
EKQPVY
NPAT
GDV
L
LEIAE
A
SAE
Q
V
D
A
AV
R
AA
DAA
F
--AE
W
GQTT
P
KV
R
AEC
L
L
K
LA
D
V
IE
ENGQ
V
F
A
E
LE
SR
N
C
GK
PLHSAFND
EI
PAIVDVFR
F
F
AG
AARCLN
G
LAAGEY
---
LEGHTSMI--R
R
D
PLGV
V
A
S
I
A
PWN
Y
P
LM
M
AA
WK
LA
PALAAGN
C
VV
L
KPSE
I
TPLTAL
KL
A
E
L
AK
DI
-
F
P
A
GV
I
N
I
L
F
G
R
G
KTV
G
DP
LT
G
HP
K
V
RM
VS
L
TGS
IA
TG
E
H
I
ISH
T
-
A
S
S
IKR
T
H
M
ELGGK
A
P
V
IV
FD
D
-
AD
-----
I
E
A
V
VEGVRTFGYY
N
A
GQ
D
C
TAAC
R
I
YAQKGIY
D
T
L
VEKLGAAVATL
K
S
G
APDDES
-
TEL
GPL
S
S
L
AH
L
E
R
V
SKA
V
EE
A
KAT
G
H
IK
V
IT
G
G
--
EKRK
G
--
-
-
N
GY
YYA
PTL
LAGALQDDA
I
VQ
K
E
V
FGPV
V
S
V
TPFDNE
E
QV
V
NW
ANDSQYGL
A
S
S
V
W
T
K
D
V
GR
A
H
R
V
S
AR
L
Q
Y
G
CT
WVN
THFMLVSEM
P
H
GG
Q
K
L
SG
Y
G
KDM
S
LYG
L
ED
Y
TVV
R
H
V
M
V
fig|656414.3.peg.1730
Escherichia coli H736 (1-472/474)
M
Q
HK
L
L
ING
ELVSG-EG
---
EKQPVY
NPAT
GDV
L
LEIAE
A
SAE
Q
V
D
A
AV
R
AA
DAA
F
--AE
W
GQTT
P
KV
R
AEC
L
L
K
LA
D
V
IE
ENGQ
V
F
A
E
LE
SR
N
C
GK
PLHSAFND
EI
PAIVDVFR
F
F
AG
AARCLN
G
LAAGEY
---
LEGHTSMI--R
R
D
PLGV
V
A
S
I
A
PWN
Y
P
LM
M
AA
WK
LA
PALAAGN
C
VV
L
KPSE
I
TPLTAL
KL
A
E
L
AK
DI
-
F
P
A
GV
I
N
I
L
F
G
R
G
KTV
G
DP
LT
G
HP
K
V
RM
VS
L
TGS
IA
TG
E
H
I
ISH
T
-
A
S
S
IKR
T
H
M
ELGGK
A
P
V
IV
FD
D
-
AD
-----
I
E
A
V
VEGVRTFGYY
N
A
GQ
D
C
TAAC
R
I
YAQKGIY
D
T
L
VEKLGAAVATL
K
S
G
APDDES
-
TEL
GPL
S
S
L
AH
L
E
R
V
SKA
V
EE
A
KAT
G
H
IK
V
IT
G
G
--
EKRK
G
--
-
-
N
GY
YYA
PTL
LAGALQDDA
I
VQ
K
E
V
FGPV
V
S
V
TPFDNE
E
QV
V
NW
ANDSQYGL
A
S
S
V
W
T
K
D
V
GR
A
H
R
V
S
AR
L
Q
Y
G
CT
WVN
THFMLVSEM
P
H
GG
Q
K
L
SG
Y
G
KDM
S
LYG
L
ED
Y
TVV
R
H
V
M
V
fig|749537.3.peg.971
Escherichia coli MS 115-1 (1-472/474)
M
Q
HK
L
L
ING
ELVSG-EG
---
EKQPVY
NPAT
GDV
L
LEIAE
A
SAE
Q
V
D
A
AV
R
AA
DAA
F
--AE
W
GQTT
P
KV
R
AEC
L
L
K
LA
D
V
IE
ENGQ
V
F
A
E
LE
SR
N
C
GK
PLHSAFND
EI
PAIVDVFR
F
F
AG
AARCLN
G
LAAGEY
---
LEGHTSMI--R
R
D
PLGV
V
A
S
I
A
PWN
Y
P
LM
M
AA
WK
LA
PALAAGN
C
VV
L
KPSE
I
TPLTAL
KL
A
E
L
AK
DI
-
F
P
A
GV
I
N
I
L
F
G
R
G
KTV
G
DP
LT
G
HP
K
V
RM
VS
L
TGS
IA
TG
E
H
I
ISH
T
-
A
S
S
IKR
T
H
M
ELGGK
A
P
V
IV
FD
D
-
AD
-----
I
E
A
V
VEGVRTFGYY
N
A
GQ
D
C
TAAC
R
I
YAQKGIY
D
T
L
VEKLGAAVATL
K
S
G
APDDES
-
TEL
GPL
S
S
L
AH
L
E
R
V
SKA
V
EE
A
KAT
G
H
IK
V
IT
G
G
--
EKRK
G
--
-
-
N
GY
YYA
PTL
LAGALQDDA
I
VQ
K
E
V
FGPV
V
S
V
TPFDNE
E
QV
V
NW
ANDSQYGL
A
S
S
V
W
T
K
D
V
GR
A
H
R
V
S
AR
L
Q
Y
G
CT
WVN
THFMLVSEM
P
H
GG
Q
K
L
SG
Y
G
KDM
S
LYG
L
ED
Y
TVV
R
H
V
M
V
fig|749538.3.peg.1564
Escherichia coli MS 116-1 (1-472/474)
M
Q
HK
L
L
ING
ELVSG-EG
---
EKQPVY
NPAT
GDV
L
LEIAE
A
SAE
Q
V
D
A
AV
R
AA
DAA
F
--AE
W
GQTT
P
KV
R
AEC
L
L
K
LA
D
V
IE
ENGQ
V
F
A
E
LE
SR
N
C
GK
PLHSAFND
EI
PAIVDVFR
F
F
AG
AARCLN
G
LAAGEY
---
LEGHTSMI--R
R
D
PLGV
V
A
S
I
A
PWN
Y
P
LM
M
AA
WK
LA
PALAAGN
C
VV
L
KPSE
I
TPLTAL
KL
A
E
L
AK
DI
-
F
P
A
GV
I
N
I
L
F
G
R
G
KTV
G
DP
LT
G
HP
K
V
RM
VS
L
TGS
IA
TG
E
H
I
ISH
T
-
A
S
S
IKR
T
H
M
ELGGK
A
P
V
IV
FD
D
-
AD
-----
I
E
A
V
VEGVRTFGYY
N
A
GQ
D
C
TAAC
R
I
YAQKGIY
D
T
L
VEKLGAAVATL
K
S
G
APDDES
-
TEL
GPL
S
S
L
AH
L
E
R
V
SKA
V
EE
A
KAT
G
H
IK
V
IT
G
G
--
EKRK
G
--
-
-
N
GY
YYA
PTL
LAGALQDDA
I
VQ
K
E
V
FGPV
V
S
V
TPFDNE
E
QV
V
NW
ANDSQYGL
A
S
S
V
W
T
K
D
V
GR
A
H
R
V
S
AR
L
Q
Y
G
CT
WVN
THFMLVSEM
P
H
GG
Q
K
L
SG
Y
G
KDM
S
LYG
L
ED
Y
TVV
R
H
V
M
V
fig|749540.3.peg.1932
Escherichia coli MS 146-1 (1-472/474)
M
Q
HK
L
L
ING
ELVSG-EG
---
EKQPVY
NPAT
GDV
L
LEIAE
A
SAE
Q
V
D
A
AV
R
AA
DAA
F
--AE
W
GQTT
P
KV
R
AEC
L
L
K
LA
D
V
IE
ENGQ
V
F
A
E
LE
SR
N
C
GK
PLHSAFND
EI
PAIVDVFR
F
F
AG
AARCLN
G
LAAGEY
---
LEGHTSMI--R
R
D
PLGV
V
A
S
I
A
PWN
Y
P
LM
M
AA
WK
LA
PALAAGN
C
VV
L
KPSE
I
TPLTAL
KL
A
E
L
AK
DI
-
F
P
A
GV
I
N
I
L
F
G
R
G
KTV
G
DP
LT
G
HP
K
V
RM
VS
L
TGS
IA
TG
E
H
I
ISH
T
-
A
S
S
IKR
T
H
M
ELGGK
A
P
V
IV
FD
D
-
AD
-----
I
E
A
V
VEGVRTFGYY
N
A
GQ
D
C
TAAC
R
I
YAQKGIY
D
T
L
VEKLGAAVATL
K
S
G
APDDES
-
TEL
GPL
S
S
L
AH
L
E
R
V
SKA
V
EE
A
KAT
G
H
IK
V
IT
G
G
--
EKRK
G
--
-
-
N
GY
YYA
PTL
LAGALQDDA
I
VQ
K
E
V
FGPV
V
S
V
TPFDNE
E
QV
V
NW
ANDSQYGL
A
S
S
V
W
T
K
D
V
GR
A
H
R
V
S
AR
L
Q
Y
G
CT
WVN
THFMLVSEM
P
H
GG
Q
K
L
SG
Y
G
KDM
S
LYG
L
ED
Y
TVV
R
H
V
M
V
fig|749547.3.peg.1273
Escherichia coli MS 187-1 (1-472/474)
M
Q
HK
L
L
ING
ELVSG-EG
---
EKQPVY
NPAT
GDV
L
LEIAE
A
SAE
Q
V
D
A
AV
R
AA
DAA
F
--AE
W
GQTT
P
KV
R
AEC
L
L
K
LA
D
V
IE
ENGQ
V
F
A
E
LE
SR
N
C
GK
PLHSAFND
EI
PAIVDVFR
F
F
AG
AARCLN
G
LAAGEY
---
LEGHTSMI--R
R
D
PLGV
V
A
S
I
A
PWN
Y
P
LM
M
AA
WK
LA
PALAAGN
C
VV
L
KPSE
I
TPLTAL
KL
A
E
L
AK
DI
-
F
P
A
GV
I
N
I
L
F
G
R
G
KTV
G
DP
LT
G
HP
K
V
RM
VS
L
TGS
IA
TG
E
H
I
ISH
T
-
A
S
S
IKR
T
H
M
ELGGK
A
P
V
IV
FD
D
-
AD
-----
I
E
A
V
VEGVRTFGYY
N
A
GQ
D
C
TAAC
R
I
YAQKGIY
D
T
L
VEKLGAAVATL
K
S
G
APDDES
-
TEL
GPL
S
S
L
AH
L
E
R
V
SKA
V
EE
A
KAT
G
H
IK
V
IT
G
G
--
EKRK
G
--
-
-
N
GY
YYA
PTL
LAGALQDDA
I
VQ
K
E
V
FGPV
V
S
V
TPFDNE
E
QV
V
NW
ANDSQYGL
A
S
S
V
W
T
K
D
V
GR
A
H
R
V
S
AR
L
Q
Y
G
CT
WVN
THFMLVSEM
P
H
GG
Q
K
L
SG
Y
G
KDM
S
LYG
L
ED
Y
TVV
R
H
V
M
V
fig|749548.3.peg.798
Escherichia coli MS 196-1 (1-472/474)
M
Q
HK
L
L
ING
ELVSG-EG
---
EKQPVY
NPAT
GDV
L
LEIAE
A
SAE
Q
V
D
A
AV
R
AA
DAA
F
--AE
W
GQTT
P
KV
R
AEC
L
L
K
LA
D
V
IE
ENGQ
V
F
A
E
LE
SR
N
C
GK
PLHSAFND
EI
PAIVDVFR
F
F
AG
AARCLN
G
LAAGEY
---
LEGHTSMI--R
R
D
PLGV
V
A
S
I
A
PWN
Y
P
LM
M
AA
WK
LA
PALAAGN
C
VV
L
KPSE
I
TPLTAL
KL
A
E
L
AK
DI
-
F
P
A
GV
I
N
I
L
F
G
R
G
KTV
G
DP
LT
G
HP
K
V
RM
VS
L
TGS
IA
TG
E
H
I
ISH
T
-
A
S
S
IKR
T
H
M
ELGGK
A
P
V
IV
FD
D
-
AD
-----
I
E
A
V
VEGVRTFGYY
N
A
GQ
D
C
TAAC
R
I
YAQKGIY
D
T
L
VEKLGAAVATL
K
S
G
APDDES
-
TEL
GPL
S
S
L
AH
L
E
R
V
SKA
V
EE
A
KAT
G
H
IK
V
IT
G
G
--
EKRK
G
--
-
-
N
GY
YYA
PTL
LAGALQDDA
I
VQ
K
E
V
FGPV
V
S
V
TPFDNE
E
QV
V
NW
ANDSQYGL
A
S
S
V
W
T
K
D
V
GR
A
H
R
V
S
AR
L
Q
Y
G
CT
WVN
THFMLVSEM
P
H
GG
Q
K
L
SG
Y
G
KDM
S
LYG
L
ED
Y
TVV
R
H
V
M
V
fig|481805.3.peg.2378
Escherichia coli ATCC 8739 (1-472/474)
M
Q
HK
L
L
ING
ELVSG-EG
---
EKQPVY
NPAT
GDV
L
LEIAE
A
SAE
Q
V
D
A
AV
R
AA
DAA
F
--AE
W
GQTT
P
KV
R
AEC
L
L
K
LA
D
V
IE
ENGQ
V
F
A
E
LE
SR
N
C
GK
PLHSAFND
EI
PAIVDVFR
F
F
AG
AARCLN
G
LAAGEY
---
LEGHTSMI--R
R
D
PLGV
V
A
S
I
A
PWN
Y
P
LM
M
AA
WK
LA
PALAAGN
C
VV
L
KPSE
I
TPLTAL
KL
A
E
L
AK
DI
-
F
P
A
GV
I
N
I
L
F
G
R
G
KTV
G
DP
LT
G
HP
K
V
RM
VS
L
TGS
IA
TG
E
H
I
ISH
T
-
A
S
S
IKR
T
H
M
ELGGK
A
P
V
IV
FD
D
-
AD
-----
I
E
A
V
VEGVRTFGYY
N
A
GQ
D
C
TAAC
R
I
YAQKGIY
D
T
L
VEKLGAAVATL
K
S
G
APDDES
-
TEL
GPL
S
S
L
AH
L
E
R
V
SKA
V
EE
A
KAT
G
H
IK
V
IT
G
G
--
EKRK
G
--
-
-
N
GY
YYA
PTL
LAGALQDDA
I
VQ
K
E
V
FGPV
V
S
V
TLFDNE
E
QV
V
NW
ANDSQYGL
A
S
S
V
W
T
K
D
V
GR
A
H
R
V
S
AR
L
Q
Y
G
CT
WVN
THFMLVSEM
P
H
GG
Q
K
L
SG
Y
G
KDM
S
LYG
L
ED
Y
TVV
R
H
V
M
V
fig|481805.6.peg.2368
Escherichia coli ATCC 8739 (1-472/474)
M
Q
HK
L
L
ING
ELVSG-EG
---
EKQPVY
NPAT
GDV
L
LEIAE
A
SAE
Q
V
D
A
AV
R
AA
DAA
F
--AE
W
GQTT
P
KV
R
AEC
L
L
K
LA
D
V
IE
ENGQ
V
F
A
E
LE
SR
N
C
GK
PLHSAFND
EI
PAIVDVFR
F
F
AG
AARCLN
G
LAAGEY
---
LEGHTSMI--R
R
D
PLGV
V
A
S
I
A
PWN
Y
P
LM
M
AA
WK
LA
PALAAGN
C
VV
L
KPSE
I
TPLTAL
KL
A
E
L
AK
DI
-
F
P
A
GV
I
N
I
L
F
G
R
G
KTV
G
DP
LT
G
HP
K
V
RM
VS
L
TGS
IA
TG
E
H
I
ISH
T
-
A
S
S
IKR
T
H
M
ELGGK
A
P
V
IV
FD
D
-
AD
-----
I
E
A
V
VEGVRTFGYY
N
A
GQ
D
C
TAAC
R
I
YAQKGIY
D
T
L
VEKLGAAVATL
K
S
G
APDDES
-
TEL
GPL
S
S
L
AH
L
E
R
V
SKA
V
EE
A
KAT
G
H
IK
V
IT
G
G
--
EKRK
G
--
-
-
N
GY
YYA
PTL
LAGALQDDA
I
VQ
K
E
V
FGPV
V
S
V
TLFDNE
E
QV
V
NW
ANDSQYGL
A
S
S
V
W
T
K
D
V
GR
A
H
R
V
S
AR
L
Q
Y
G
CT
WVN
THFMLVSEM
P
H
GG
Q
K
L
SG
Y
G
KDM
S
LYG
L
ED
Y
TVV
R
H
V
M
V
fig|340186.3.peg.201
Escherichia coli E110019 (1-472/474)
M
Q
HK
L
L
ING
ELVSG-EG
---
EKQPVY
NPAT
GDV
L
LEIAE
A
SAE
Q
V
D
A
AV
R
AA
DAA
F
--AE
W
GQTT
P
KV
R
AEC
L
L
K
LA
D
V
IE
ENGQ
V
F
A
E
LE
SR
N
C
GK
PLHSAFND
EI
PAIVDVFR
F
F
AG
AARCLN
G
LAAGEY
---
LEGHTSMI--R
R
D
PLGV
V
A
S
I
A
PWN
Y
P
LM
M
AA
WK
LA
PALAAGN
C
VV
L
KPSE
I
TPLTAL
KL
A
E
L
AK
DI
-
F
P
A
GV
I
N
I
L
F
G
R
G
KTV
G
DP
LT
G
HP
K
V
RM
VS
L
TGS
IA
TG
E
H
I
ISH
T
-
A
S
S
IKR
T
H
M
ELGGK
A
P
V
IV
FD
D
-
AD
-----
I
E
A
V
VEGVRTFGYY
N
A
GQ
D
C
TAAC
R
I
YAQKGIY
D
T
L
VEKLGAAVATL
K
S
G
APDDES
-
TEL
GPL
S
S
L
AH
L
E
R
V
SKA
V
EE
A
KAT
G
H
IK
V
IT
G
G
--
EKRK
G
--
-
-
N
GY
YYA
PTL
LAGALQDDA
I
VQ
K
E
V
FGPV
V
S
V
TLFDNE
E
QV
V
NW
ANDSQYGL
A
S
S
V
W
T
K
D
V
GR
A
H
R
V
S
AR
L
Q
Y
G
CT
WVN
THFMLVSEM
P
H
GG
Q
K
L
SG
Y
G
KDM
S
LYG
L
ED
Y
TVV
R
H
V
M
V
fig|340186.5.peg.216
Escherichia coli E110019 (1-472/474)
M
Q
HK
L
L
ING
ELVSG-EG
---
EKQPVY
NPAT
GDV
L
LEIAE
A
SAE
Q
V
D
A
AV
R
AA
DAA
F
--AE
W
GQTT
P
KV
R
AEC
L
L
K
LA
D
V
IE
ENGQ
V
F
A
E
LE
SR
N
C
GK
PLHSAFND
EI
PAIVDVFR
F
F
AG
AARCLN
G
LAAGEY
---
LEGHTSMI--R
R
D
PLGV
V
A
S
I
A
PWN
Y
P
LM
M
AA
WK
LA
PALAAGN
C
VV
L
KPSE
I
TPLTAL
KL
A
E
L
AK
DI
-
F
P
A
GV
I
N
I
L
F
G
R
G
KTV
G
DP
LT
G
HP
K
V
RM
VS
L
TGS
IA
TG
E
H
I
ISH
T
-
A
S
S
IKR
T
H
M
ELGGK
A
P
V
IV
FD
D
-
AD
-----
I
E
A
V
VEGVRTFGYY
N
A
GQ
D
C
TAAC
R
I
YAQKGIY
D
T
L
VEKLGAAVATL
K
S
G
APDDES
-
TEL
GPL
S
S
L
AH
L
E
R
V
SKA
V
EE
A
KAT
G
H
IK
V
IT
G
G
--
EKRK
G
--
-
-
N
GY
YYA
PTL
LAGALQDDA
I
VQ
K
E
V
FGPV
V
S
V
TLFDNE
E
QV
V
NW
ANDSQYGL
A
S
S
V
W
T
K
D
V
GR
A
H
R
V
S
AR
L
Q
Y
G
CT
WVN
THFMLVSEM
P
H
GG
Q
K
L
SG
Y
G
KDM
S
LYG
L
ED
Y
TVV
R
H
V
M
V
fig|331112.3.peg.1434
Escherichia coli HS (1-472/474)
M
Q
HK
L
L
ING
ELVSG-EG
---
EKQPVY
NPAT
GDV
L
LEIAE
A
SAE
Q
V
D
A
AV
R
AA
DAA
F
--AE
W
GQTT
P
KV
R
AEC
L
L
K
LA
D
V
IE
ENGQ
V
F
A
E
LE
SR
N
C
GK
PLHSAFND
EI
PAIVDVFR
F
F
AG
AARCLN
G
LAAGEY
---
LEGHTSMI--R
R
D
PLGV
V
A
S
I
A
PWN
Y
P
LM
M
AA
WK
LA
PALAAGN
C
VV
L
KPSE
I
TPLTAL
KL
A
E
L
AK
DI
-
F
P
A
GV
I
N
I
L
F
G
R
G
KTV
G
DP
LT
G
HP
K
V
RM
VS
L
TGS
IA
TG
E
H
I
ISH
T
-
A
S
S
IKR
T
H
M
ELGGK
A
P
V
IV
FD
D
-
AD
-----
I
E
A
V
VEGVRTFGYY
N
A
GQ
D
C
TAAC
R
I
YAQKGIY
D
T
L
VEKLGAAVATL
K
S
G
APDDES
-
TEL
GPL
S
S
L
AH
L
E
R
V
SKA
V
EE
A
KAT
G
H
IK
V
IT
G
G
--
EKRK
G
--
-
-
N
GY
YYA
PTL
LAGALQDDA
I
VQ
K
E
V
FGPV
V
S
V
TLFDNE
E
QV
V
NW
ANDSQYGL
A
S
S
V
W
T
K
D
V
GR
A
H
R
V
S
AR
L
Q
Y
G
CT
WVN
THFMLVSEM
P
H
GG
Q
K
L
SG
Y
G
KDM
S
LYG
L
ED
Y
TVV
R
H
V
M
V
fig|331112.6.peg.1493
Escherichia coli HS (1-472/474)
M
Q
HK
L
L
ING
ELVSG-EG
---
EKQPVY
NPAT
GDV
L
LEIAE
A
SAE
Q
V
D
A
AV
R
AA
DAA
F
--AE
W
GQTT
P
KV
R
AEC
L
L
K
LA
D
V
IE
ENGQ
V
F
A
E
LE
SR
N
C
GK
PLHSAFND
EI
PAIVDVFR
F
F
AG
AARCLN
G
LAAGEY
---
LEGHTSMI--R
R
D
PLGV
V
A
S
I
A
PWN
Y
P
LM
M
AA
WK
LA
PALAAGN
C
VV
L
KPSE
I
TPLTAL
KL
A
E
L
AK
DI
-
F
P
A
GV
I
N
I
L
F
G
R
G
KTV
G
DP
LT
G
HP
K
V
RM
VS
L
TGS
IA
TG
E
H
I
ISH
T
-
A
S
S
IKR
T
H
M
ELGGK
A
P
V
IV
FD
D
-
AD
-----
I
E
A
V
VEGVRTFGYY
N
A
GQ
D
C
TAAC
R
I
YAQKGIY
D
T
L
VEKLGAAVATL
K
S
G
APDDES
-
TEL
GPL
S
S
L
AH
L
E
R
V
SKA
V
EE
A
KAT
G
H
IK
V
IT
G
G
--
EKRK
G
--
-
-
N
GY
YYA
PTL
LAGALQDDA
I
VQ
K
E
V
FGPV
V
S
V
TLFDNE
E
QV
V
NW
ANDSQYGL
A
S
S
V
W
T
K
D
V
GR
A
H
R
V
S
AR
L
Q
Y
G
CT
WVN
THFMLVSEM
P
H
GG
Q
K
L
SG
Y
G
KDM
S
LYG
L
ED
Y
TVV
R
H
V
M
V
fig|550676.3.peg.1013
Escherichia coli B185 (1-472/474)
M
Q
HK
L
L
ING
ELVSG-EG
---
EKQPVY
NPAT
GDV
L
LEIAE
A
SAE
Q
V
D
A
AV
R
AA
DAA
F
--AE
W
GQTT
P
KV
R
AEC
L
L
K
LA
D
V
IE
ENGQ
V
F
A
E
LE
SR
N
C
GK
PLHSAFND
EI
PAIVDVFR
F
F
AG
AARCLN
G
LAAGEY
---
LEGHTSMI--R
R
D
PLGV
V
A
S
I
A
PWN
Y
P
LM
M
AA
WK
LA
PALAAGN
C
VV
L
KPSE
I
TPLTAL
KL
A
E
L
AK
DI
-
F
P
A
GV
I
NV
L
F
G
R
G
KTV
G
DP
LT
G
HP
K
V
RM
VS
L
TGS
IA
TG
E
H
I
ISH
T
-
A
P
S
IKR
T
H
M
ELGGK
A
P
V
IV
FD
D
-
AD
-----
I
E
A
V
VEGVRTFGYY
N
A
GQ
D
C
TAAC
R
I
YAQKGIY
D
T
L
VEKLGAAVATL
K
S
G
APDDES
-
TEL
GPL
S
S
L
AH
L
E
R
V
SKA
V
EE
A
KAT
G
H
IK
V
IT
G
G
--
EKRK
G
--
-
-
N
GY
YYA
PTL
LAGALQDDA
I
VQ
K
E
V
FGPV
V
S
V
TPFDNE
E
QV
V
NW
ANDSQYGL
A
S
S
V
W
T
K
D
V
GR
A
H
R
V
S
AR
L
Q
Y
G
CT
WVN
THFMLVSEM
P
H
GG
Q
K
L
SG
Y
G
KDM
S
LYG
L
ED
Y
TVV
R
H
V
M
V
fig|656393.3.peg.2176
Escherichia coli H299 (1-472/474)
M
Q
HK
L
L
ING
ELVSG-EG
---
EKQPVY
NPAT
GDV
L
LEIAE
A
SAE
Q
V
D
A
AV
R
AA
DAA
F
--AE
W
GQTT
P
KV
R
AEC
L
L
K
LA
D
V
IE
ENGQ
V
F
A
E
LE
SR
N
C
GK
PLHSAFND
EI
PAIVDVFR
F
F
AG
AARCLN
G
LAAGEY
---
LEGHTSMI--R
R
D
PLGV
V
A
S
I
A
PWN
Y
P
LM
M
AA
WK
LA
PALAAGN
C
VV
L
KPSE
I
TPLTAL
KL
A
E
L
AK
DI
-
F
P
A
GV
I
NV
L
F
G
R
G
KTV
G
DP
LT
G
HP
K
V
RM
VS
L
TGS
IA
TG
E
H
I
ISH
T
-
A
P
S
IKR
T
H
M
ELGGK
A
P
V
IV
FD
D
-
AD
-----
I
E
A
V
VEGVRTFGYY
N
A
GQ
D
C
TAAC
R
I
YAQKGIY
D
T
L
VEKLGAAVATL
K
S
G
APDDES
-
TEL
GPL
S
S
L
AH
L
E
R
V
SKA
V
EE
A
KAT
G
H
IK
V
IT
G
G
--
EKRK
G
--
-
-
N
GY
YYA
PTL
LAGALQDDA
I
VQ
K
E
V
FGPV
V
S
V
TLFDNE
E
QV
V
NW
ANDSQYGL
A
S
S
V
W
T
K
D
V
GR
A
H
R
V
S
AR
L
Q
Y
G
CT
WVN
THFMLVSEM
P
H
GG
Q
K
L
SG
Y
G
KDM
S
LYG
L
ED
Y
TVV
R
H
V
M
V
fig|749531.3.peg.417
Escherichia coli MS 69-1 (1-472/474)
M
Q
HK
L
L
ING
ELVSG-EG
---
EKQPVY
NPAT
GDV
L
LEIAE
A
SAE
Q
V
D
A
AV
R
AA
DAA
F
--AE
W
GQTT
P
KV
R
AEC
L
L
K
LA
D
V
IE
ENGQ
V
F
A
E
LE
SR
N
C
GK
PLHSAFND
EI
PAIVDVFR
F
F
AG
AARCLN
G
LAAGEY
---
LEGHTSMI--R
R
D
PLGV
V
A
S
I
A
PWN
Y
P
LM
M
AA
WK
LA
PALAAGN
C
VV
L
KPSE
I
TPLTAL
KL
A
E
L
AK
DI
-
F
P
A
GV
I
NV
L
F
G
R
G
KTV
G
DP
LT
G
HP
K
V
RM
VS
L
TGS
IA
TG
E
H
I
ISH
T
-
A
P
S
IKR
T
H
M
ELGGK
A
P
V
IV
FD
D
-
AD
-----
I
E
A
V
VEGVRTFGYY
N
A
GQ
D
C
TAAC
R
I
YAQKGIY
D
T
L
VEKLGAAVATL
K
S
G
APDDES
-
TEL
GPL
S
S
L
AH
L
E
R
V
SKA
V
EE
A
KAT
G
H
IK
V
IT
G
G
--
EKRK
G
--
-
-
N
GY
YYA
PTL
LAGALQDDA
I
VQ
K
E
V
FGPV
V
S
V
TLFDNE
E
QV
V
NW
ANDSQYGL
A
S
S
V
W
T
K
D
V
GR
A
H
R
V
S
AR
L
Q
Y
G
CT
WVN
THFMLVSEM
P
H
GG
Q
K
L
SG
Y
G
KDM
S
LYG
L
ED
Y
TVV
R
H
V
M
V
fig|701177.3.peg.1792
Escherichia coli O55:H7 str. CB9615 (1-472/474)
M
Q
HK
L
L
ING
ELVSG-EG
---
EKQPVY
NPAT
GDV
L
LEIAE
A
SAE
Q
V
D
A
AV
R
AA
DAA
F
--AE
W
GQTT
P
KV
R
AEC
L
L
K
LA
D
V
IE
ENGQ
V
F
A
E
LE
SR
N
C
GK
PLHSAFND
EI
PAIVDVFR
F
F
AG
AARCLN
G
LAAGEY
---
LEGHTSMI--R
R
D
PLGV
V
A
S
I
A
PWN
Y
P
LM
M
AA
WK
LA
PALAAGN
C
VV
L
KPSE
I
TPLTAL
KL
A
E
L
AK
DI
-
F
P
A
GV
I
NV
L
F
G
R
G
KTV
G
DP
LT
G
HP
K
V
RM
VS
L
TGS
IA
TG
E
H
I
ISH
T
-
A
P
S
IKR
T
H
M
ELGGK
A
P
V
IV
FD
D
-
AD
-----
I
E
A
V
VEGVRTFGYY
N
A
GQ
D
C
TAAC
R
I
YAQKGIY
D
T
L
VEKLGAAVATL
K
S
G
APDDES
-
TEL
GPL
S
S
L
AH
L
E
R
V
SKA
V
EE
A
KAT
G
H
IK
V
IT
G
G
--
EKRK
G
--
-
-
N
GY
YYA
PTL
LAGALQDDA
I
VQ
K
E
V
FGPV
V
S
V
TLFDNE
E
QV
V
NW
ANDSQYGL
A
S
S
V
W
T
K
D
V
GR
A
H
R
V
S
AR
L
Q
Y
G
CT
WVN
THFMLVSEM
P
H
GG
Q
K
L
SG
Y
G
KDM
S
LYG
L
ED
Y
TVV
R
H
V
M
V
fig|550677.3.peg.2852
Escherichia coli B354 (1-472/474)
M
Q
HK
L
L
ING
ELVSG-EG
---
EKQPVY
NPAT
GDV
L
LEIAE
A
SAE
Q
V
D
A
AV
R
AA
DAA
F
--AE
W
GQTT
P
KV
R
AEC
L
L
K
LA
D
V
IE
ENGQ
V
F
A
E
LE
SR
N
C
GK
PLHSAFND
EI
PAIVDVFR
F
F
AG
AARCLN
G
LAAGEY
---
LEGHTSMI--R
R
D
PLGV
V
A
S
I
A
PWN
Y
P
LM
M
AA
WK
LA
PALAAGN
C
VV
L
KPSE
I
TPLTAL
KL
A
E
L
AK
DI
-
F
P
A
GV
I
NV
L
F
G
R
G
KTV
G
DP
LT
G
HP
K
V
RM
VS
L
TGS
IA
TG
E
H
I
ISH
T
-
A
P
S
IKR
T
H
M
ELGGK
A
P
V
IV
FD
D
-
AD
-----
I
E
A
V
VEGVRTFGYY
N
A
GQ
D
C
TAAC
R
I
YAQKGIY
D
T
L
VEKLGAAVATL
K
S
G
APDDDS
-
TEL
GPL
S
S
L
AH
L
E
R
V
SKA
V
EE
A
KAT
G
H
IK
V
IT
G
G
--
EKRK
G
--
-
-
N
GY
YYA
PTL
LAGALQDDA
I
VQ
K
E
V
FGPV
V
S
V
TLFDNE
E
QV
V
NW
ANDSQYGL
A
S
S
V
W
T
K
D
V
GR
A
H
R
V
S
AR
L
Q
Y
G
CT
WVN
THFMLVSEM
P
H
GG
Q
K
L
SG
Y
G
KDM
S
LYG
L
ED
Y
TVV
R
H
V
M
V
fig|595496.3.peg.1398
Escherichia coli BW2952 (1-472/474)
M
Q
HK
L
L
ING
ELVSG-EG
---
EKQPVY
NPAT
GDV
L
LEIAE
A
SAE
Q
V
D
A
AV
R
AA
DAA
F
--AE
W
GQTT
P
KV
R
AEC
L
L
K
LA
D
V
IE
ENGQ
V
F
A
E
LE
SR
N
C
GK
PLHSAFND
EI
PAIVDVFR
F
F
AG
AARCLN
G
LAAGEY
---
LEGHTSMI--R
R
D
PLGV
V
A
S
I
A
PWN
Y
P
LM
M
AA
WK
LA
PALAAGN
C
VV
L
KPSE
I
TPLTAL
KL
A
E
L
AK
DI
-
F
P
A
GV
I
N
I
L
F
G
R
G
KTV
G
DP
LT
G
HP
K
V
RM
VS
L
TGS
IA
TG
E
H
I
ISH
T
-
A
S
S
IKR
T
H
M
ELGGK
A
P
V
IV
FD
D
-
AD
-----
I
E
A
V
VEGVRTFGYY
N
A
GQ
D
C
TAAC
R
I
YAQKGIY
D
T
L
VEKLGAAVATL
K
S
G
APDDES
-
TEL
GPL
S
S
L
AH
L
E
R
V
GKA
V
EE
A
KAT
G
H
IK
V
IT
G
G
--
EKRK
G
--
-
-
N
GY
YYA
PTL
LAGALQDDA
I
VQ
K
E
V
FGPV
V
S
V
TPFDNE
E
QV
V
NW
ANDSQYGL
A
S
S
V
W
T
K
D
V
GR
A
H
R
V
S
AR
L
Q
Y
G
CT
WVN
THFMLVSEM
P
H
GG
Q
K
L
SG
Y
G
KDM
S
LYG
L
ED
Y
TVV
R
H
V
M
V
fig|536056.3.peg.2312
Escherichia coli DH1 (1-472/474)
M
Q
HK
L
L
ING
ELVSG-EG
---
EKQPVY
NPAT
GDV
L
LEIAE
A
SAE
Q
V
D
A
AV
R
AA
DAA
F
--AE
W
GQTT
P
KV
R
AEC
L
L
K
LA
D
V
IE
ENGQ
V
F
A
E
LE
SR
N
C
GK
PLHSAFND
EI
PAIVDVFR
F
F
AG
AARCLN
G
LAAGEY
---
LEGHTSMI--R
R
D
PLGV
V
A
S
I
A
PWN
Y
P
LM
M
AA
WK
LA
PALAAGN
C
VV
L
KPSE
I
TPLTAL
KL
A
E
L
AK
DI
-
F
P
A
GV
I
N
I
L
F
G
R
G
KTV
G
DP
LT
G
HP
K
V
RM
VS
L
TGS
IA
TG
E
H
I
ISH
T
-
A
S
S
IKR
T
H
M
ELGGK
A
P
V
IV
FD
D
-
AD
-----
I
E
A
V
VEGVRTFGYY
N
A
GQ
D
C
TAAC
R
I
YAQKGIY
D
T
L
VEKLGAAVATL
K
S
G
APDDES
-
TEL
GPL
S
S
L
AH
L
E
R
V
GKA
V
EE
A
KAT
G
H
IK
V
IT
G
G
--
EKRK
G
--
-
-
N
GY
YYA
PTL
LAGALQDDA
I
VQ
K
E
V
FGPV
V
S
V
TPFDNE
E
QV
V
NW
ANDSQYGL
A
S
S
V
W
T
K
D
V
GR
A
H
R
V
S
AR
L
Q
Y
G
CT
WVN
THFMLVSEM
P
H
GG
Q
K
L
SG
Y
G
KDM
S
LYG
L
ED
Y
TVV
R
H
V
M
V
fig|83333.1.peg.1430
Escherichia coli K12 (1-472/474)
M
Q
HK
L
L
ING
ELVSG-EG
---
EKQPVY
NPAT
GDV
L
LEIAE
A
SAE
Q
V
D
A
AV
R
AA
DAA
F
--AE
W
GQTT
P
KV
R
AEC
L
L
K
LA
D
V
IE
ENGQ
V
F
A
E
LE
SR
N
C
GK
PLHSAFND
EI
PAIVDVFR
F
F
AG
AARCLN
G
LAAGEY
---
LEGHTSMI--R
R
D
PLGV
V
A
S
I
A
PWN
Y
P
LM
M
AA
WK
LA
PALAAGN
C
VV
L
KPSE
I
TPLTAL
KL
A
E
L
AK
DI
-
F
P
A
GV
I
N
I
L
F
G
R
G
KTV
G
DP
LT
G
HP
K
V
RM
VS
L
TGS
IA
TG
E
H
I
ISH
T
-
A
S
S
IKR
T
H
M
ELGGK
A
P
V
IV
FD
D
-
AD
-----
I
E
A
V
VEGVRTFGYY
N
A
GQ
D
C
TAAC
R
I
YAQKGIY
D
T
L
VEKLGAAVATL
K
S
G
APDDES
-
TEL
GPL
S
S
L
AH
L
E
R
V
GKA
V
EE
A
KAT
G
H
IK
V
IT
G
G
--
EKRK
G
--
-
-
N
GY
YYA
PTL
LAGALQDDA
I
VQ
K
E
V
FGPV
V
S
V
TPFDNE
E
QV
V
NW
ANDSQYGL
A
S
S
V
W
T
K
D
V
GR
A
H
R
V
S
AR
L
Q
Y
G
CT
WVN
THFMLVSEM
P
H
GG
Q
K
L
SG
Y
G
KDM
S
LYG
L
ED
Y
TVV
R
H
V
M
V
fig|316407.3.peg.1403
Escherichia coli W3110 (1-472/474)
M
Q
HK
L
L
ING
ELVSG-EG
---
EKQPVY
NPAT
GDV
L
LEIAE
A
SAE
Q
V
D
A
AV
R
AA
DAA
F
--AE
W
GQTT
P
KV
R
AEC
L
L
K
LA
D
V
IE
ENGQ
V
F
A
E
LE
SR
N
C
GK
PLHSAFND
EI
PAIVDVFR
F
F
AG
AARCLN
G
LAAGEY
---
LEGHTSMI--R
R
D
PLGV
V
A
S
I
A
PWN
Y
P
LM
M
AA
WK
LA
PALAAGN
C
VV
L
KPSE
I
TPLTAL
KL
A
E
L
AK
DI
-
F
P
A
GV
I
N
I
L
F
G
R
G
KTV
G
DP
LT
G
HP
K
V
RM
VS
L
TGS
IA
TG
E
H
I
ISH
T
-
A
S
S
IKR
T
H
M
ELGGK
A
P
V
IV
FD
D
-
AD
-----
I
E
A
V
VEGVRTFGYY
N
A
GQ
D
C
TAAC
R
I
YAQKGIY
D
T
L
VEKLGAAVATL
K
S
G
APDDES
-
TEL
GPL
S
S
L
AH
L
E
R
V
GKA
V
EE
A
KAT
G
H
IK
V
IT
G
G
--
EKRK
G
--
-
-
N
GY
YYA
PTL
LAGALQDDA
I
VQ
K
E
V
FGPV
V
S
V
TPFDNE
E
QV
V
NW
ANDSQYGL
A
S
S
V
W
T
K
D
V
GR
A
H
R
V
S
AR
L
Q
Y
G
CT
WVN
THFMLVSEM
P
H
GG
Q
K
L
SG
Y
G
KDM
S
LYG
L
ED
Y
TVV
R
H
V
M
V
fig|316385.5.peg.1557
Escherichia coli str. K-12 substr. DH10B (1-472/474)
M
Q
HK
L
L
ING
ELVSG-EG
---
EKQPVY
NPAT
GDV
L
LEIAE
A
SAE
Q
V
D
A
AV
R
AA
DAA
F
--AE
W
GQTT
P
KV
R
AEC
L
L
K
LA
D
V
IE
ENGQ
V
F
A
E
LE
SR
N
C
GK
PLHSAFND
EI
PAIVDVFR
F
F
AG
AARCLN
G
LAAGEY
---
LEGHTSMI--R
R
D
PLGV
V
A
S
I
A
PWN
Y
P
LM
M
AA
WK
LA
PALAAGN
C
VV
L
KPSE
I
TPLTAL
KL
A
E
L
AK
DI
-
F
P
A
GV
I
N
I
L
F
G
R
G
KTV
G
DP
LT
G
HP
K
V
RM
VS
L
TGS
IA
TG
E
H
I
ISH
T
-
A
S
S
IKR
T
H
M
ELGGK
A
P
V
IV
FD
D
-
AD
-----
I
E
A
V
VEGVRTFGYY
N
A
GQ
D
C
TAAC
R
I
YAQKGIY
D
T
L
VEKLGAAVATL
K
S
G
APDDES
-
TEL
GPL
S
S
L
AH
L
E
R
V
GKA
V
EE
A
KAT
G
H
IK
V
IT
G
G
--
EKRK
G
--
-
-
N
GY
YYA
PTL
LAGALQDDA
I
VQ
K
E
V
FGPV
V
S
V
TPFDNE
E
QV
V
NW
ANDSQYGL
A
S
S
V
W
T
K
D
V
GR
A
H
R
V
S
AR
L
Q
Y
G
CT
WVN
THFMLVSEM
P
H
GG
Q
K
L
SG
Y
G
KDM
S
LYG
L
ED
Y
TVV
R
H
V
M
V
fig|316385.7.peg.1597
Escherichia coli str. K-12 substr. DH10B (1-472/474)
M
Q
HK
L
L
ING
ELVSG-EG
---
EKQPVY
NPAT
GDV
L
LEIAE
A
SAE
Q
V
D
A
AV
R
AA
DAA
F
--AE
W
GQTT
P
KV
R
AEC
L
L
K
LA
D
V
IE
ENGQ
V
F
A
E
LE
SR
N
C
GK
PLHSAFND
EI
PAIVDVFR
F
F
AG
AARCLN
G
LAAGEY
---
LEGHTSMI--R
R
D
PLGV
V
A
S
I
A
PWN
Y
P
LM
M
AA
WK
LA
PALAAGN
C
VV
L
KPSE
I
TPLTAL
KL
A
E
L
AK
DI
-
F
P
A
GV
I
N
I
L
F
G
R
G
KTV
G
DP
LT
G
HP
K
V
RM
VS
L
TGS
IA
TG
E
H
I
ISH
T
-
A
S
S
IKR
T
H
M
ELGGK
A
P
V
IV
FD
D
-
AD
-----
I
E
A
V
VEGVRTFGYY
N
A
GQ
D
C
TAAC
R
I
YAQKGIY
D
T
L
VEKLGAAVATL
K
S
G
APDDES
-
TEL
GPL
S
S
L
AH
L
E
R
V
GKA
V
EE
A
KAT
G
H
IK
V
IT
G
G
--
EKRK
G
--
-
-
N
GY
YYA
PTL
LAGALQDDA
I
VQ
K
E
V
FGPV
V
S
V
TPFDNE
E
QV
V
NW
ANDSQYGL
A
S
S
V
W
T
K
D
V
GR
A
H
R
V
S
AR
L
Q
Y
G
CT
WVN
THFMLVSEM
P
H
GG
Q
K
L
SG
Y
G
KDM
S
LYG
L
ED
Y
TVV
R
H
V
M
V
fig|511145.12.peg.1509
Escherichia coli str. K-12 substr. MG1655 (1-472/474)
M
Q
HK
L
L
ING
ELVSG-EG
---
EKQPVY
NPAT
GDV
L
LEIAE
A
SAE
Q
V
D
A
AV
R
AA
DAA
F
--AE
W
GQTT
P
KV
R
AEC
L
L
K
LA
D
V
IE
ENGQ
V
F
A
E
LE
SR
N
C
GK
PLHSAFND
EI
PAIVDVFR
F
F
AG
AARCLN
G
LAAGEY
---
LEGHTSMI--R
R
D
PLGV
V
A
S
I
A
PWN
Y
P
LM
M
AA
WK
LA
PALAAGN
C
VV
L
KPSE
I
TPLTAL
KL
A
E
L
AK
DI
-
F
P
A
GV
I
N
I
L
F
G
R
G
KTV
G
DP
LT
G
HP
K
V
RM
VS
L
TGS
IA
TG
E
H
I
ISH
T
-
A
S
S
IKR
T
H
M
ELGGK
A
P
V
IV
FD
D
-
AD
-----
I
E
A
V
VEGVRTFGYY
N
A
GQ
D
C
TAAC
R
I
YAQKGIY
D
T
L
VEKLGAAVATL
K
S
G
APDDES
-
TEL
GPL
S
S
L
AH
L
E
R
V
GKA
V
EE
A
KAT
G
H
IK
V
IT
G
G
--
EKRK
G
--
-
-
N
GY
YYA
PTL
LAGALQDDA
I
VQ
K
E
V
FGPV
V
S
V
TPFDNE
E
QV
V
NW
ANDSQYGL
A
S
S
V
W
T
K
D
V
GR
A
H
R
V
S
AR
L
Q
Y
G
CT
WVN
THFMLVSEM
P
H
GG
Q
K
L
SG
Y
G
KDM
S
LYG
L
ED
Y
TVV
R
H
V
M
V
fig|511145.6.peg.1496
Escherichia coli str. K-12 substr. MG1655 (1-472/474)
M
Q
HK
L
L
ING
ELVSG-EG
---
EKQPVY
NPAT
GDV
L
LEIAE
A
SAE
Q
V
D
A
AV
R
AA
DAA
F
--AE
W
GQTT
P
KV
R
AEC
L
L
K
LA
D
V
IE
ENGQ
V
F
A
E
LE
SR
N
C
GK
PLHSAFND
EI
PAIVDVFR
F
F
AG
AARCLN
G
LAAGEY
---
LEGHTSMI--R
R
D
PLGV
V
A
S
I
A
PWN
Y
P
LM
M
AA
WK
LA
PALAAGN
C
VV
L
KPSE
I
TPLTAL
KL
A
E
L
AK
DI
-
F
P
A
GV
I
N
I
L
F
G
R
G
KTV
G
DP
LT
G
HP
K
V
RM
VS
L
TGS
IA
TG
E
H
I
ISH
T
-
A
S
S
IKR
T
H
M
ELGGK
A
P
V
IV
FD
D
-
AD
-----
I
E
A
V
VEGVRTFGYY
N
A
GQ
D
C
TAAC
R
I
YAQKGIY
D
T
L
VEKLGAAVATL
K
S
G
APDDES
-
TEL
GPL
S
S
L
AH
L
E
R
V
GKA
V
EE
A
KAT
G
H
IK
V
IT
G
G
--
EKRK
G
--
-
-
N
GY
YYA
PTL
LAGALQDDA
I
VQ
K
E
V
FGPV
V
S
V
TPFDNE
E
QV
V
NW
ANDSQYGL
A
S
S
V
W
T
K
D
V
GR
A
H
R
V
S
AR
L
Q
Y
G
CT
WVN
THFMLVSEM
P
H
GG
Q
K
L
SG
Y
G
KDM
S
LYG
L
ED
Y
TVV
R
H
V
M
V
fig|216592.1.peg.1980
Escherichia coli 042 (1-472/474)
M
Q
HK
L
L
ING
ELVSG-EG
---
EKQPVY
NPAT
GEV
L
LEIAE
A
SAE
Q
V
D
A
AV
R
AA
DAA
F
--AE
W
GQTT
P
KA
R
AEC
L
L
K
LA
D
V
IE
ENGQ
V
F
A
E
LE
SR
N
C
GK
PLHSAFND
EI
PAIVDVFR
F
F
AG
AARCLN
G
LAAGEY
---
LEGHTSMI--R
R
D
PLGV
V
A
S
I
A
PWN
Y
P
LM
M
AA
WK
LA
PALAAGN
C
VV
L
KPSE
I
TPLTAL
KL
A
E
L
AK
DI
-
F
P
A
GV
I
NV
L
F
G
R
G
KTV
G
DP
LT
G
HP
K
V
RM
VS
L
TGS
IA
TG
E
H
I
ISH
T
-
A
P
S
IK
L
T
H
M
ELGGK
A
P
V
IV
FD
D
-
AD
-----
I
E
A
V
VEGVRTFGYY
N
A
GQ
D
C
TAAC
R
I
YAQKGIY
D
T
L
VEKLGAAVATL
K
S
G
APDDES
-
TEL
GPL
S
S
L
AH
L
D
R
V
SKA
V
EE
A
KAT
G
H
IK
V
IT
G
G
--
EKRK
G
--
-
-
N
GY
YYA
PTL
LAGALQDDA
I
VQ
K
E
V
FGPV
V
S
V
TLFDNE
E
QV
V
NW
ANDSQYGL
A
S
S
V
W
T
K
D
V
GR
A
H
R
V
S
AR
L
Q
Y
G
CT
WVN
THFMLVSEM
P
H
GG
Q
K
L
SG
Y
G
KDM
S
LYG
L
ED
Y
TVV
R
H
V
M
V
fig|216592.3.peg.1632
Escherichia coli 042 (1-472/474)
M
Q
HK
L
L
ING
ELVSG-EG
---
EKQPVY
NPAT
GEV
L
LEIAE
A
SAE
Q
V
D
A
AV
R
AA
DAA
F
--AE
W
GQTT
P
KA
R
AEC
L
L
K
LA
D
V
IE
ENGQ
V
F
A
E
LE
SR
N
C
GK
PLHSAFND
EI
PAIVDVFR
F
F
AG
AARCLN
G
LAAGEY
---
LEGHTSMI--R
R
D
PLGV
V
A
S
I
A
PWN
Y
P
LM
M
AA
WK
LA
PALAAGN
C
VV
L
KPSE
I
TPLTAL
KL
A
E
L
AK
DI
-
F
P
A
GV
I
NV
L
F
G
R
G
KTV
G
DP
LT
G
HP
K
V
RM
VS
L
TGS
IA
TG
E
H
I
ISH
T
-
A
P
S
IK
L
T
H
M
ELGGK
A
P
V
IV
FD
D
-
AD
-----
I
E
A
V
VEGVRTFGYY
N
A
GQ
D
C
TAAC
R
I
YAQKGIY
D
T
L
VEKLGAAVATL
K
S
G
APDDES
-
TEL
GPL
S
S
L
AH
L
D
R
V
SKA
V
EE
A
KAT
G
H
IK
V
IT
G
G
--
EKRK
G
--
-
-
N
GY
YYA
PTL
LAGALQDDA
I
VQ
K
E
V
FGPV
V
S
V
TLFDNE
E
QV
V
NW
ANDSQYGL
A
S
S
V
W
T
K
D
V
GR
A
H
R
V
S
AR
L
Q
Y
G
CT
WVN
THFMLVSEM
P
H
GG
Q
K
L
SG
Y
G
KDM
S
LYG
L
ED
Y
TVV
R
H
V
M
V
fig|656379.3.peg.3479
Escherichia coli FVEC1302 (1-472/474)
M
Q
HK
L
L
ING
ELVSG-EG
---
EKQPVY
NPAT
GEV
L
LEIAE
A
SAE
Q
V
D
A
AV
R
AA
DAA
F
--AE
W
GQTT
P
KA
R
AEC
L
L
K
LA
D
V
IE
ENGQ
V
F
A
E
LE
SR
N
C
GK
PLHSAFND
EI
PAIVDVFR
F
F
AG
AARCLN
G
LAAGEY
---
LEGHTSMI--R
R
D
PLGV
V
A
S
I
A
PWN
Y
P
LM
M
AA
WK
LA
PALAAGN
C
VV
L
KPSE
I
TPLTAL
KL
A
E
L
AK
DI
-
F
P
A
GV
I
NV
L
F
G
R
G
KTV
G
DP
LT
G
HP
K
V
RM
VS
L
TGS
IA
TG
E
H
I
ISH
T
-
A
P
S
IK
L
T
H
M
ELGGK
A
P
V
IV
FD
D
-
AD
-----
I
E
A
V
VEGVRTFGYY
N
A
GQ
D
C
TAAC
R
I
YAQKGIY
D
T
L
VEKLGAAVATL
K
S
G
APDDES
-
TEL
GPL
S
S
L
AH
L
D
R
V
SKA
V
EE
A
KAT
G
H
IK
V
IT
G
G
--
EKRK
G
--
-
-
N
GY
YYA
PTL
LAGALQDDA
I
VQ
K
E
V
FGPV
V
S
V
TLFDNE
E
QV
V
NW
ANDSQYGL
A
S
S
V
W
T
K
D
V
GR
A
H
R
V
S
AR
L
Q
Y
G
CT
WVN
THFMLVSEM
P
H
GG
Q
K
L
SG
Y
G
KDM
S
LYG
L
ED
Y
TVV
R
H
V
M
V
fig|656380.3.peg.2833
Escherichia coli FVEC1412 (1-472/474)
M
Q
HK
L
L
ING
ELVSG-EG
---
EKQPVY
NPAT
GEV
L
LEIAE
A
SAE
Q
V
D
A
AV
R
AA
DAA
F
--AE
W
GQTT
P
KA
R
AEC
L
L
K
LA
D
V
IE
ENGQ
V
F
A
E
LE
SR
N
C
GK
PLHSAFND
EI
PAIVDVFR
F
F
AG
AARCLN
G
LAAGEY
---
LEGHTSMI--R
R
D
PLGV
V
A
S
I
A
PWN
Y
P
LM
M
AA
WK
LA
PALAAGN
C
VV
L
KPSE
I
TPLTAL
KL
A
E
L
AK
DI
-
F
P
A
GV
I
NV
L
F
G
R
G
KTV
G
DP
LT
G
HP
K
V
RM
VS
L
TGS
IA
TG
E
H
I
ISH
T
-
A
P
S
IK
L
T
H
M
ELGGK
A
P
V
IV
FD
D
-
AD
-----
I
E
A
V
VEGVRTFGYY
N
A
GQ
D
C
TAAC
R
I
YAQKGIY
D
T
L
VEKLGAAVATL
K
S
G
APDDES
-
TEL
GPL
S
S
L
AH
L
D
R
V
SKA
V
EE
A
KAT
G
H
IK
V
IT
G
G
--
EKRK
G
--
-
-
N
GY
YYA
PTL
LAGALQDDA
I
VQ
K
E
V
FGPV
V
S
V
TLFDNE
E
QV
V
NW
ANDSQYGL
A
S
S
V
W
T
K
D
V
GR
A
H
R
V
S
AR
L
Q
Y
G
CT
WVN
THFMLVSEM
P
H
GG
Q
K
L
SG
Y
G
KDM
S
LYG
L
ED
Y
TVV
R
H
V
M
V
fig|749549.3.peg.3878
Escherichia coli MS 198-1 (1-472/474)
M
Q
HK
L
L
ING
ELVSG-EG
---
EKQPVY
NPAT
GEV
L
LEIAE
A
SAE
Q
V
D
A
AV
R
AA
DAA
F
--AE
W
GQTT
P
KA
R
AEC
L
L
K
LA
D
V
IE
ENGQ
V
F
A
E
LE
SR
N
C
GK
PLHSAFND
EI
PAIVDVFR
F
F
AG
AARCLN
G
LAAGEY
---
LEGHTSMI--R
R
D
PLGV
V
A
S
I
A
PWN
Y
P
LM
M
AA
WK
LA
PALAAGN
C
VV
L
KPSE
I
TPLTAL
KL
A
E
L
AK
DI
-
F
P
A
GV
I
NV
L
F
G
R
G
KTV
G
DP
LT
G
HP
K
V
RM
VS
L
TGS
IA
TG
E
H
I
ISH
T
-
A
P
S
IK
L
T
H
M
ELGGK
A
P
V
IV
FD
D
-
AD
-----
I
E
A
V
VEGVRTFGYY
N
A
GQ
D
C
TAAC
R
I
YAQKGIY
D
T
L
VEKLGAAVATL
K
S
G
APDDES
-
TEL
GPL
S
S
L
AH
L
D
R
V
SKA
V
EE
A
KAT
G
H
IK
V
IT
G
G
--
EKRK
G
--
-
-
N
GY
YYA
PTL
LAGALQDDA
I
VQ
K
E
V
FGPV
V
S
V
TLFDNE
E
QV
V
NW
ANDSQYGL
A
S
S
V
W
T
K
D
V
GR
A
H
R
V
S
AR
L
Q
Y
G
CT
WVN
THFMLVSEM
P
H
GG
Q
K
L
SG
Y
G
KDM
S
LYG
L
ED
Y
TVV
R
H
V
M
V
fig|585056.7.peg.1883
Escherichia coli UMN026 (1-472/474)
M
Q
HK
L
L
ING
ELVSG-EG
---
EKQPVY
NPAT
GEV
L
LEIAE
A
SAE
Q
V
D
A
AV
R
AA
DAA
F
--AE
W
GQTT
P
KA
R
AEC
L
L
K
LA
D
V
IE
ENGQ
V
F
A
E
LE
SR
N
C
GK
PLHSAFND
EI
PAIVDVFR
F
F
AG
AARCLN
G
LAAGEY
---
LEGHTSMI--R
R
D
PLGV
V
A
S
I
A
PWN
Y
P
LM
M
AA
WK
LA
PALAAGN
C
VV
L
KPSE
I
TPLTAL
KL
A
E
L
AK
DI
-
F
P
A
GV
I
NV
L
F
G
R
G
KTV
G
DP
LT
G
HP
K
V
RM
VS
L
TGS
IA
TG
E
H
I
ISH
T
-
A
P
S
IK
L
T
H
M
ELGGK
A
P
V
IV
FD
D
-
AD
-----
I
E
A
V
VEGVRTFGYY
N
A
GQ
D
C
TAAC
R
I
YAQKGIY
D
T
L
VEKLGAAVATL
K
S
G
APDDES
-
TEL
GPL
S
S
L
AH
L
D
R
V
SKA
V
EE
A
KAT
G
H
IK
V
IT
G
G
--
EKRK
G
--
-
-
N
GY
YYA
PTL
LAGALQDDA
I
VQ
K
E
V
FGPV
V
S
V
TLFDNE
E
QV
V
NW
ANDSQYGL
A
S
S
V
W
T
K
D
V
GR
A
H
R
V
S
AR
L
Q
Y
G
CT
WVN
THFMLVSEM
P
H
GG
Q
K
L
SG
Y
G
KDM
S
LYG
L
ED
Y
TVV
R
H
V
M
V
fig|656440.3.peg.1309
Escherichia coli TA206 (1-472/474)
M
Q
HK
L
L
ING
ELVSG-EG
---
EKQPVY
NPAT
GDV
L
LEIAE
A
SAE
Q
V
D
A
AV
R
AA
DAA
F
--AE
W
GQTT
P
KA
R
AEC
L
L
K
LA
D
V
IE
ENGQ
V
F
A
E
LE
SR
N
C
GK
PLHSAFND
EI
PAIVDVFR
F
F
AG
AARCLN
G
LAAGEY
---
LEGHTSMI--R
R
D
PLGV
V
A
S
I
A
PWN
Y
P
LM
M
AA
WK
LA
PALAAGN
C
VV
L
KPSE
I
TPLTAL
KL
A
E
L
AK
DI
-
F
P
A
GV
I
NV
L
F
G
R
G
KTV
G
DP
LT
G
HP
K
V
RM
VS
L
TGS
IA
TG
E
H
I
ISH
T
-
A
P
S
IKR
T
H
M
ELGGK
A
P
V
IV
FD
D
-
AD
-----
I
E
A
V
VEGVRTFGYY
N
A
GQ
D
C
TAAC
R
I
YAQKGIY
D
T
L
VEKLGAAVATL
K
S
G
SPDDES
-
TEL
GPL
S
S
L
AH
L
E
R
V
SKA
V
EE
A
KAT
G
H
IK
V
IT
G
G
--
EKRK
G
--
-
-
N
GY
YYA
PTL
LAGALQDDA
I
VQ
K
E
V
FGPV
V
S
V
SLFDNE
E
QV
V
NW
ANDSQYGL
A
S
S
V
W
T
K
D
V
GR
A
H
R
V
S
AR
L
Q
Y
G
CT
WVN
THFMLVSEM
P
H
GG
Q
K
L
SG
Y
G
KDM
S
LYG
L
ED
Y
TVV
R
H
V
M
V
fig|550672.3.peg.937
Escherichia coli B088 (1-472/474)
M
Q
HK
L
L
ING
ELVSG-EG
---
EKQPVY
NPAT
GDV
L
LEIAE
A
SAE
Q
V
D
A
AV
R
AA
DAA
F
--AE
W
GQTT
P
KV
R
AEC
L
L
K
LA
D
V
IE
ENGQ
V
F
A
E
LE
SR
N
C
GK
PLHSAFND
EI
PAIVDVFR
F
F
AG
AARCLN
G
LAAGEY
---
LEGHTSMI--R
R
D
PLGV
V
A
S
I
A
PWN
Y
P
LM
M
AA
WK
LA
PALAAGN
C
VV
L
KPSE
I
TPLTAL
KL
A
E
L
AK
DI
-
F
P
A
GV
I
NV
L
F
G
R
G
KTV
G
DP
LT
G
HP
K
V
RM
VS
L
TGS
IA
TG
E
H
I
ISH
T
-
A
S
S
IKR
T
H
M
ELGGK
A
P
V
IV
FD
D
-
AD
-----
I
E
A
V
VEGVRTFGYY
N
A
GQ
D
C
TAAC
R
I
YAQKGIY
D
T
L
VEKLGAAVATL
K
S
G
APDDES
-
TEL
GPL
S
S
L
AH
L
E
R
V
SKA
V
EE
A
KAT
G
H
IK
V
IT
G
G
--
EKRK
G
--
-
-
N
GY
YYA
PTL
LAGALQDDA
I
VQ
K
E
V
FGPV
V
S
V
TPFDNE
E
QV
V
NW
ANDSQYGL
A
S
S
V
W
T
K
D
V
GR
A
H
R
V
S
AR
VQ
Y
G
CT
WVN
THFMLVSEM
P
H
GG
Q
K
L
SG
Y
G
KDM
S
LYG
L
ED
Y
TVV
R
H
V
M
V
fig|753642.3.peg.1719
Escherichia coli NC101 (1-472/474)
M
Q
HK
L
L
ING
ELVRG-EG
---
EKQPVY
NPAT
GDV
L
LEIAE
A
SAE
Q
V
N
A
AV
R
AA
DAA
F
--AE
W
GQTT
P
KA
R
AEC
L
L
K
LA
D
V
IE
ENGQ
V
F
A
E
LE
SR
N
C
GK
PLHSAFND
EI
PAIVDVFR
F
F
AG
AARCLN
G
LAAGEY
---
LEGHTSMI--R
R
D
PLGV
V
A
S
I
A
PWN
Y
P
LM
M
AA
WK
LA
PALAAGN
C
VV
L
KPSE
I
TPLTAL
KL
A
E
L
AK
DI
-
F
P
A
GV
I
NV
L
F
G
R
G
KTV
G
DP
LT
G
HP
K
V
RM
VS
L
TGS
IA
TG
E
H
I
ISH
T
-
A
P
S
IKR
T
H
M
ELGGK
A
P
V
IV
FD
D
-
AD
-----
I
E
A
V
VEGVRTFGYY
N
A
GQ
D
C
TAAC
R
I
YAQKGIY
D
T
L
VEKLGAAVATL
K
S
G
APDDES
-
TEL
GPL
S
S
L
AH
L
E
R
V
SKA
V
EE
A
KAT
G
H
IK
V
IT
G
G
--
EKRK
G
--
-
-
N
GY
YYA
PTL
LAGALQDDA
I
VQ
K
E
V
FGPV
V
S
V
TLFDNE
E
QV
V
NW
AN
G
SQYGL
A
S
S
V
W
T
K
D
V
GR
A
H
R
V
S
AR
L
Q
Y
G
CT
WVN
THFMLVSEM
P
H
GG
Q
K
L
SG
Y
G
KDM
S
LYG
L
ED
Y
TVV
R
H
V
M
V
fig|344610.3.peg.1057
Escherichia coli 53638 (1-472/474)
M
Q
HK
L
L
ING
ELVSG-EG
---
EKQPVY
NPAT
GDV
L
LEIAE
A
SAE
Q
V
D
A
AV
R
AA
DAA
F
--AE
W
GQTT
P
KV
R
AEC
L
L
K
LA
D
V
IE
ENGQ
V
F
A
E
LE
SR
N
C
GK
PLHSAFND
EI
PAIVDVFR
F
F
AG
AARCLN
G
LAAGEY
---
LEGHTSMI--R
R
D
PLGV
V
A
S
I
A
PWN
Y
P
LM
M
AA
WK
LA
PALAAGN
C
VV
L
KPSE
I
TPLTAL
KL
A
E
L
AK
DI
-
F
P
A
GV
I
N
I
L
F
G
R
G
KTV
G
DP
LT
G
HP
K
V
RM
VS
L
TGS
IA
TG
E
H
I
ISH
T
-
A
S
S
IKR
T
H
M
ELGGK
A
P
V
IV
FD
D
-
AD
-----
I
E
A
V
VEGVRTFGYY
N
A
GQ
D
C
TVAC
R
I
YAQKGIY
D
T
L
VEKLGAAVATL
K
S
G
APDDES
-
TEL
GPL
S
S
L
AH
L
E
R
V
SKA
V
EE
A
KAT
G
H
IK
V
IT
G
G
--
EKRK
G
--
-
-
N
GY
YYA
PTL
LAGALQDDA
I
VQ
K
E
V
FGPV
V
S
V
TPFDNE
E
QV
V
NW
ANDSQYGL
A
S
S
V
W
T
K
D
V
GR
A
H
R
V
S
AR
L
Q
Y
G
CT
WVN
THFMLVSEM
P
H
GG
Q
K
L
SG
Y
G
KDM
S
LYG
L
ED
Y
TVV
R
H
V
M
V
fig|344610.7.peg.5105
Escherichia coli 53638 (1-472/474)
M
Q
HK
L
L
ING
ELVSG-EG
---
EKQPVY
NPAT
GDV
L
LEIAE
A
SAE
Q
V
D
A
AV
R
AA
DAA
F
--AE
W
GQTT
P
KV
R
AEC
L
L
K
LA
D
V
IE
ENGQ
V
F
A
E
LE
SR
N
C
GK
PLHSAFND
EI
PAIVDVFR
F
F
AG
AARCLN
G
LAAGEY
---
LEGHTSMI--R
R
D
PLGV
V
A
S
I
A
PWN
Y
P
LM
M
AA
WK
LA
PALAAGN
C
VV
L
KPSE
I
TPLTAL
KL
A
E
L
AK
DI
-
F
P
A
GV
I
N
I
L
F
G
R
G
KTV
G
DP
LT
G
HP
K
V
RM
VS
L
TGS
IA
TG
E
H
I
ISH
T
-
A
S
S
IKR
T
H
M
ELGGK
A
P
V
IV
FD
D
-
AD
-----
I
E
A
V
VEGVRTFGYY
N
A
GQ
D
C
TVAC
R
I
YAQKGIY
D
T
L
VEKLGAAVATL
K
S
G
APDDES
-
TEL
GPL
S
S
L
AH
L
E
R
V
SKA
V
EE
A
KAT
G
H
IK
V
IT
G
G
--
EKRK
G
--
-
-
N
GY
YYA
PTL
LAGALQDDA
I
VQ
K
E
V
FGPV
V
S
V
TPFDNE
E
QV
V
NW
ANDSQYGL
A
S
S
V
W
T
K
D
V
GR
A
H
R
V
S
AR
L
Q
Y
G
CT
WVN
THFMLVSEM
P
H
GG
Q
K
L
SG
Y
G
KDM
S
LYG
L
ED
Y
TVV
R
H
V
M
V
fig|562.371.peg.1770
Escherichia coli 1044A (1-472/474)
M
Q
HK
L
L
ING
ELVSG-EG
---
EKQPVY
NPAT
GDV
L
LEIAE
A
SAE
Q
V
D
A
AV
R
AA
DAA
F
--AE
W
GQTT
P
KV
R
AEC
L
L
K
LA
D
V
IE
ENGQ
V
F
A
E
LE
SR
N
C
GK
PLHSAFND
EI
PAIVDVFR
F
F
AG
AARCLN
G
LAAGEY
---
LEGHTSMI--R
R
D
PLGV
V
A
S
I
A
PWN
Y
P
LM
M
AA
WK
LA
PALAAGN
C
VV
L
KPSE
I
TPLTAL
KL
A
E
L
AK
DI
-
F
P
A
GV
I
NV
L
F
G
R
G
KTV
G
DP
LT
G
HP
K
V
RM
VS
L
TGS
IA
TG
E
H
I
ISH
T
-
A
P
S
IKR
T
H
M
ELGGK
A
P
V
IV
FD
D
-
AD
-----
I
E
A
V
VEGVRTFGYY
N
A
GQ
D
C
TVAC
R
I
YAQKGIY
D
T
L
VEKLGAAVATL
K
S
G
APDDES
-
TEL
GPL
S
S
L
AH
L
E
R
V
SKA
V
EE
A
KAT
G
H
IK
V
IT
G
G
--
EKRK
G
--
-
-
N
GY
YYA
PTL
LAGALQDDA
I
VQ
K
E
V
FGPV
V
S
V
TLFDNE
E
QV
V
NW
ANDSQYGL
A
S
S
V
W
T
K
D
V
GR
A
H
R
V
S
AR
L
Q
Y
G
CT
WVN
THFMLVSEM
P
H
GG
Q
K
L
SG
Y
G
KDM
S
LYG
L
ED
Y
TVV
R
H
V
M
V
fig|562.373.peg.5116
Escherichia coli 1125A (1-472/474)
M
Q
HK
L
L
ING
ELVSG-EG
---
EKQPVY
NPAT
GDV
L
LEIAE
A
SAE
Q
V
D
A
AV
R
AA
DAA
F
--AE
W
GQTT
P
KV
R
AEC
L
L
K
LA
D
V
IE
ENGQ
V
F
A
E
LE
SR
N
C
GK
PLHSAFND
EI
PAIVDVFR
F
F
AG
AARCLN
G
LAAGEY
---
LEGHTSMI--R
R
D
PLGV
V
A
S
I
A
PWN
Y
P
LM
M
AA
WK
LA
PALAAGN
C
VV
L
KPSE
I
TPLTAL
KL
A
E
L
AK
DI
-
F
P
A
GV
I
NV
L
F
G
R
G
KTV
G
DP
LT
G
HP
K
V
RM
VS
L
TGS
IA
TG
E
H
I
ISH
T
-
A
P
S
IKR
T
H
M
ELGGK
A
P
V
IV
FD
D
-
AD
-----
I
E
A
V
VEGVRTFGYY
N
A
GQ
D
C
TVAC
R
I
YAQKGIY
D
T
L
VEKLGAAVATL
K
S
G
APDDES
-
TEL
GPL
S
S
L
AH
L
E
R
V
SKA
V
EE
A
KAT
G
H
IK
V
IT
G
G
--
EKRK
G
--
-
-
N
GY
YYA
PTL
LAGALQDDA
I
VQ
K
E
V
FGPV
V
S
V
TLFDNE
E
QV
V
NW
ANDSQYGL
A
S
S
V
W
T
K
D
V
GR
A
H
R
V
S
AR
L
Q
Y
G
CT
WVN
THFMLVSEM
P
H
GG
Q
K
L
SG
Y
G
KDM
S
LYG
L
ED
Y
TVV
R
H
V
M
V
fig|562.372.peg.1255
Escherichia coli 1212A (1-472/474)
M
Q
HK
L
L
ING
ELVSG-EG
---
EKQPVY
NPAT
GDV
L
LEIAE
A
SAE
Q
V
D
A
AV
R
AA
DAA
F
--AE
W
GQTT
P
KV
R
AEC
L
L
K
LA
D
V
IE
ENGQ
V
F
A
E
LE
SR
N
C
GK
PLHSAFND
EI
PAIVDVFR
F
F
AG
AARCLN
G
LAAGEY
---
LEGHTSMI--R
R
D
PLGV
V
A
S
I
A
PWN
Y
P
LM
M
AA
WK
LA
PALAAGN
C
VV
L
KPSE
I
TPLTAL
KL
A
E
L
AK
DI
-
F
P
A
GV
I
NV
L
F
G
R
G
KTV
G
DP
LT
G
HP
K
V
RM
VS
L
TGS
IA
TG
E
H
I
ISH
T
-
A
P
S
IKR
T
H
M
ELGGK
A
P
V
IV
FD
D
-
AD
-----
I
E
A
V
VEGVRTFGYY
N
A
GQ
D
C
TVAC
R
I
YAQKGIY
D
T
L
VEKLGAAVATL
K
S
G
APDDES
-
TEL
GPL
S
S
L
AH
L
E
R
V
SKA
V
EE
A
KAT
G
H
IK
V
IT
G
G
--
EKRK
G
--
-
-
N
GY
YYA
PTL
LAGALQDDA
I
VQ
K
E
V
FGPV
V
S
V
TLFDNE
E
QV
V
NW
ANDSQYGL
A
S
S
V
W
T
K
D
V
GR
A
H
R
V
S
AR
L
Q
Y
G
CT
WVN
THFMLVSEM
P
H
GG
Q
K
L
SG
Y
G
KDM
S
LYG
L
ED
Y
TVV
R
H
V
M
V
fig|562.374.peg.2330
Escherichia coli 536A (1-472/474)
M
Q
HK
L
L
ING
ELVSG-EG
---
EKQPVY
NPAT
GDV
L
LEIAE
A
SAE
Q
V
D
A
AV
R
AA
DAA
F
--AE
W
GQTT
P
KV
R
AEC
L
L
K
LA
D
V
IE
ENGQ
V
F
A
E
LE
SR
N
C
GK
PLHSAFND
EI
PAIVDVFR
F
F
AG
AARCLN
G
LAAGEY
---
LEGHTSMI--R
R
D
PLGV
V
A
S
I
A
PWN
Y
P
LM
M
AA
WK
LA
PALAAGN
C
VV
L
KPSE
I
TPLTAL
KL
A
E
L
AK
DI
-
F
P
A
GV
I
NV
L
F
G
R
G
KTV
G
DP
LT
G
HP
K
V
RM
VS
L
TGS
IA
TG
E
H
I
ISH
T
-
A
P
S
IKR
T
H
M
ELGGK
A
P
V
IV
FD
D
-
AD
-----
I
E
A
V
VEGVRTFGYY
N
A
GQ
D
C
TVAC
R
I
YAQKGIY
D
T
L
VEKLGAAVATL
K
S
G
APDDES
-
TEL
GPL
S
S
L
AH
L
E
R
V
SKA
V
EE
A
KAT
G
H
IK
V
IT
G
G
--
EKRK
G
--
-
-
N
GY
YYA
PTL
LAGALQDDA
I
VQ
K
E
V
FGPV
V
S
V
TLFDNE
E
QV
V
NW
ANDSQYGL
A
S
S
V
W
T
K
D
V
GR
A
H
R
V
S
AR
L
Q
Y
G
CT
WVN
THFMLVSEM
P
H
GG
Q
K
L
SG
Y
G
KDM
S
LYG
L
ED
Y
TVV
R
H
V
M
V
fig|83334.1.peg.2078
Escherichia coli O157:H7 (1-472/474)
M
Q
HK
L
L
ING
ELVSG-EG
---
EKQPVY
NPAT
GDV
L
LEIAE
A
SAE
Q
V
D
A
AV
R
AA
DAA
F
--AE
W
GQTT
P
KV
R
AEC
L
L
K
LA
D
V
IE
ENGQ
V
F
A
E
LE
SR
N
C
GK
PLHSAFND
EI
PAIVDVFR
F
F
AG
AARCLN
G
LAAGEY
---
LEGHTSMI--R
R
D
PLGV
V
A
S
I
A
PWN
Y
P
LM
M
AA
WK
LA
PALAAGN
C
VV
L
KPSE
I
TPLTAL
KL
A
E
L
AK
DI
-
F
P
A
GV
I
NV
L
F
G
R
G
KTV
G
DP
LT
G
HP
K
V
RM
VS
L
TGS
IA
TG
E
H
I
ISH
T
-
A
P
S
IKR
T
H
M
ELGGK
A
P
V
IV
FD
D
-
AD
-----
I
E
A
V
VEGVRTFGYY
N
A
GQ
D
C
TVAC
R
I
YAQKGIY
D
T
L
VEKLGAAVATL
K
S
G
APDDES
-
TEL
GPL
S
S
L
AH
L
E
R
V
SKA
V
EE
A
KAT
G
H
IK
V
IT
G
G
--
EKRK
G
--
-
-
N
GY
YYA
PTL
LAGALQDDA
I
VQ
K
E
V
FGPV
V
S
V
TLFDNE
E
QV
V
NW
ANDSQYGL
A
S
S
V
W
T
K
D
V
GR
A
H
R
V
S
AR
L
Q
Y
G
CT
WVN
THFMLVSEM
P
H
GG
Q
K
L
SG
Y
G
KDM
S
LYG
L
ED
Y
TVV
R
H
V
M
V
fig|155864.1.peg.2025
Escherichia coli O157:H7 EDL933 (1-472/474)
M
Q
HK
L
L
ING
ELVSG-EG
---
EKQPVY
NPAT
GDV
L
LEIAE
A
SAE
Q
V
D
A
AV
R
AA
DAA
F
--AE
W
GQTT
P
KV
R
AEC
L
L
K
LA
D
V
IE
ENGQ
V
F
A
E
LE
SR
N
C
GK
PLHSAFND
EI
PAIVDVFR
F
F
AG
AARCLN
G
LAAGEY
---
LEGHTSMI--R
R
D
PLGV
V
A
S
I
A
PWN
Y
P
LM
M
AA
WK
LA
PALAAGN
C
VV
L
KPSE
I
TPLTAL
KL
A
E
L
AK
DI
-
F
P
A
GV
I
NV
L
F
G
R
G
KTV
G
DP
LT
G
HP
K
V
RM
VS
L
TGS
IA
TG
E
H
I
ISH
T
-
A
P
S
IKR
T
H
M
ELGGK
A
P
V
IV
FD
D
-
AD
-----
I
E
A
V
VEGVRTFGYY
N
A
GQ
D
C
TVAC
R
I
YAQKGIY
D
T
L
VEKLGAAVATL
K
S
G
APDDES
-
TEL
GPL
S
S
L
AH
L
E
R
V
SKA
V
EE
A
KAT
G
H
IK
V
IT
G
G
--
EKRK
G
--
-
-
N
GY
YYA
PTL
LAGALQDDA
I
VQ
K
E
V
FGPV
V
S
V
TLFDNE
E
QV
V
NW
ANDSQYGL
A
S
S
V
W
T
K
D
V
GR
A
H
R
V
S
AR
L
Q
Y
G
CT
WVN
THFMLVSEM
P
H
GG
Q
K
L
SG
Y
G
KDM
S
LYG
L
ED
Y
TVV
R
H
V
M
V
fig|155864.8.peg.1851
Escherichia coli O157:H7 EDL933 (1-472/474)
M
Q
HK
L
L
ING
ELVSG-EG
---
EKQPVY
NPAT
GDV
L
LEIAE
A
SAE
Q
V
D
A
AV
R
AA
DAA
F
--AE
W
GQTT
P
KV
R
AEC
L
L
K
LA
D
V
IE
ENGQ
V
F
A
E
LE
SR
N
C
GK
PLHSAFND
EI
PAIVDVFR
F
F
AG
AARCLN
G
LAAGEY
---
LEGHTSMI--R
R
D
PLGV
V
A
S
I
A
PWN
Y
P
LM
M
AA
WK
LA
PALAAGN
C
VV
L
KPSE
I
TPLTAL
KL
A
E
L
AK
DI
-
F
P
A
GV
I
NV
L
F
G
R
G
KTV
G
DP
LT
G
HP
K
V
RM
VS
L
TGS
IA
TG
E
H
I
ISH
T
-
A
P
S
IKR
T
H
M
ELGGK
A
P
V
IV
FD
D
-
AD
-----
I
E
A
V
VEGVRTFGYY
N
A
GQ
D
C
TVAC
R
I
YAQKGIY
D
T
L
VEKLGAAVATL
K
S
G
APDDES
-
TEL
GPL
S
S
L
AH
L
E
R
V
SKA
V
EE
A
KAT
G
H
IK
V
IT
G
G
--
EKRK
G
--
-
-
N
GY
YYA
PTL
LAGALQDDA
I
VQ
K
E
V
FGPV
V
S
V
TLFDNE
E
QV
V
NW
ANDSQYGL
A
S
S
V
W
T
K
D
V
GR
A
H
R
V
S
AR
L
Q
Y
G
CT
WVN
THFMLVSEM
P
H
GG
Q
K
L
SG
Y
G
KDM
S
LYG
L
ED
Y
TVV
R
H
V
M
V
fig|444454.5.peg.951
Escherichia coli O157:H7 str. EC4024 (1-472/474)
M
Q
HK
L
L
ING
ELVSG-EG
---
EKQPVY
NPAT
GDV
L
LEIAE
A
SAE
Q
V
D
A
AV
R
AA
DAA
F
--AE
W
GQTT
P
KV
R
AEC
L
L
K
LA
D
V
IE
ENGQ
V
F
A
E
LE
SR
N
C
GK
PLHSAFND
EI
PAIVDVFR
F
F
AG
AARCLN
G
LAAGEY
---
LEGHTSMI--R
R
D
PLGV
V
A
S
I
A
PWN
Y
P
LM
M
AA
WK
LA
PALAAGN
C
VV
L
KPSE
I
TPLTAL
KL
A
E
L
AK
DI
-
F
P
A
GV
I
NV
L
F
G
R
G
KTV
G
DP
LT
G
HP
K
V
RM
VS
L
TGS
IA
TG
E
H
I
ISH
T
-
A
P
S
IKR
T
H
M
ELGGK
A
P
V
IV
FD
D
-
AD
-----
I
E
A
V
VEGVRTFGYY
N
A
GQ
D
C
TVAC
R
I
YAQKGIY
D
T
L
VEKLGAAVATL
K
S
G
APDDES
-
TEL
GPL
S
S
L
AH
L
E
R
V
SKA
V
EE
A
KAT
G
H
IK
V
IT
G
G
--
EKRK
G
--
-
-
N
GY
YYA
PTL
LAGALQDDA
I
VQ
K
E
V
FGPV
V
S
V
TLFDNE
E
QV
V
NW
ANDSQYGL
A
S
S
V
W
T
K
D
V
GR
A
H
R
V
S
AR
L
Q
Y
G
CT
WVN
THFMLVSEM
P
H
GG
Q
K
L
SG
Y
G
KDM
S
LYG
L
ED
Y
TVV
R
H
V
M
V
fig|444449.5.peg.279
Escherichia coli O157:H7 str. EC4042 (1-472/474)
M
Q
HK
L
L
ING
ELVSG-EG
---
EKQPVY
NPAT
GDV
L
LEIAE
A
SAE
Q
V
D
A
AV
R
AA
DAA
F
--AE
W
GQTT
P
KV
R
AEC
L
L
K
LA
D
V
IE
ENGQ
V
F
A
E
LE
SR
N
C
GK
PLHSAFND
EI
PAIVDVFR
F
F
AG
AARCLN
G
LAAGEY
---
LEGHTSMI--R
R
D
PLGV
V
A
S
I
A
PWN
Y
P
LM
M
AA
WK
LA
PALAAGN
C
VV
L
KPSE
I
TPLTAL
KL
A
E
L
AK
DI
-
F
P
A
GV
I
NV
L
F
G
R
G
KTV
G
DP
LT
G
HP
K
V
RM
VS
L
TGS
IA
TG
E
H
I
ISH
T
-
A
P
S
IKR
T
H
M
ELGGK
A
P
V
IV
FD
D
-
AD
-----
I
E
A
V
VEGVRTFGYY
N
A
GQ
D
C
TVAC
R
I
YAQKGIY
D
T
L
VEKLGAAVATL
K
S
G
APDDES
-
TEL
GPL
S
S
L
AH
L
E
R
V
SKA
V
EE
A
KAT
G
H
IK
V
IT
G
G
--
EKRK
G
--
-
-
N
GY
YYA
PTL
LAGALQDDA
I
VQ
K
E
V
FGPV
V
S
V
TLFDNE
E
QV
V
NW
ANDSQYGL
A
S
S
V
W
T
K
D
V
GR
A
H
R
V
S
AR
L
Q
Y
G
CT
WVN
THFMLVSEM
P
H
GG
Q
K
L
SG
Y
G
KDM
S
LYG
L
ED
Y
TVV
R
H
V
M
V
fig|444448.5.peg.4635
Escherichia coli O157:H7 str. EC4045 (1-472/474)
M
Q
HK
L
L
ING
ELVSG-EG
---
EKQPVY
NPAT
GDV
L
LEIAE
A
SAE
Q
V
D
A
AV
R
AA
DAA
F
--AE
W
GQTT
P
KV
R
AEC
L
L
K
LA
D
V
IE
ENGQ
V
F
A
E
LE
SR
N
C
GK
PLHSAFND
EI
PAIVDVFR
F
F
AG
AARCLN
G
LAAGEY
---
LEGHTSMI--R
R
D
PLGV
V
A
S
I
A
PWN
Y
P
LM
M
AA
WK
LA
PALAAGN
C
VV
L
KPSE
I
TPLTAL
KL
A
E
L
AK
DI
-
F
P
A
GV
I
NV
L
F
G
R
G
KTV
G
DP
LT
G
HP
K
V
RM
VS
L
TGS
IA
TG
E
H
I
ISH
T
-
A
P
S
IKR
T
H
M
ELGGK
A
P
V
IV
FD
D
-
AD
-----
I
E
A
V
VEGVRTFGYY
N
A
GQ
D
C
TVAC
R
I
YAQKGIY
D
T
L
VEKLGAAVATL
K
S
G
APDDES
-
TEL
GPL
S
S
L
AH
L
E
R
V
SKA
V
EE
A
KAT
G
H
IK
V
IT
G
G
--
EKRK
G
--
-
-
N
GY
YYA
PTL
LAGALQDDA
I
VQ
K
E
V
FGPV
V
S
V
TLFDNE
E
QV
V
NW
ANDSQYGL
A
S
S
V
W
T
K
D
V
GR
A
H
R
V
S
AR
L
Q
Y
G
CT
WVN
THFMLVSEM
P
H
GG
Q
K
L
SG
Y
G
KDM
S
LYG
L
ED
Y
TVV
R
H
V
M
V
fig|444453.5.peg.2831
Escherichia coli O157:H7 str. EC4076 (1-472/474)
M
Q
HK
L
L
ING
ELVSG-EG
---
EKQPVY
NPAT
GDV
L
LEIAE
A
SAE
Q
V
D
A
AV
R
AA
DAA
F
--AE
W
GQTT
P
KV
R
AEC
L
L
K
LA
D
V
IE
ENGQ
V
F
A
E
LE
SR
N
C
GK
PLHSAFND
EI
PAIVDVFR
F
F
AG
AARCLN
G
LAAGEY
---
LEGHTSMI--R
R
D
PLGV
V
A
S
I
A
PWN
Y
P
LM
M
AA
WK
LA
PALAAGN
C
VV
L
KPSE
I
TPLTAL
KL
A
E
L
AK
DI
-
F
P
A
GV
I
NV
L
F
G
R
G
KTV
G
DP
LT
G
HP
K
V
RM
VS
L
TGS
IA
TG
E
H
I
ISH
T
-
A
P
S
IKR
T
H
M
ELGGK
A
P
V
IV
FD
D
-
AD
-----
I
E
A
V
VEGVRTFGYY
N
A
GQ
D
C
TVAC
R
I
YAQKGIY
D
T
L
VEKLGAAVATL
K
S
G
APDDES
-
TEL
GPL
S
S
L
AH
L
E
R
V
SKA
V
EE
A
KAT
G
H
IK
V
IT
G
G
--
EKRK
G
--
-
-
N
GY
YYA
PTL
LAGALQDDA
I
VQ
K
E
V
FGPV
V
S
V
TLFDNE
E
QV
V
NW
ANDSQYGL
A
S
S
V
W
T
K
D
V
GR
A
H
R
V
S
AR
L
Q
Y
G
CT
WVN
THFMLVSEM
P
H
GG
Q
K
L
SG
Y
G
KDM
S
LYG
L
ED
Y
TVV
R
H
V
M
V
fig|444452.5.peg.1987
Escherichia coli O157:H7 str. EC4113 (1-472/474)
M
Q
HK
L
L
ING
ELVSG-EG
---
EKQPVY
NPAT
GDV
L
LEIAE
A
SAE
Q
V
D
A
AV
R
AA
DAA
F
--AE
W
GQTT
P
KV
R
AEC
L
L
K
LA
D
V
IE
ENGQ
V
F
A
E
LE
SR
N
C
GK
PLHSAFND
EI
PAIVDVFR
F
F
AG
AARCLN
G
LAAGEY
---
LEGHTSMI--R
R
D
PLGV
V
A
S
I
A
PWN
Y
P
LM
M
AA
WK
LA
PALAAGN
C
VV
L
KPSE
I
TPLTAL
KL
A
E
L
AK
DI
-
F
P
A
GV
I
NV
L
F
G
R
G
KTV
G
DP
LT
G
HP
K
V
RM
VS
L
TGS
IA
TG
E
H
I
ISH
T
-
A
P
S
IKR
T
H
M
ELGGK
A
P
V
IV
FD
D
-
AD
-----
I
E
A
V
VEGVRTFGYY
N
A
GQ
D
C
TVAC
R
I
YAQKGIY
D
T
L
VEKLGAAVATL
K
S
G
APDDES
-
TEL
GPL
S
S
L
AH
L
E
R
V
SKA
V
EE
A
KAT
G
H
IK
V
IT
G
G
--
EKRK
G
--
-
-
N
GY
YYA
PTL
LAGALQDDA
I
VQ
K
E
V
FGPV
V
S
V
TLFDNE
E
QV
V
NW
ANDSQYGL
A
S
S
V
W
T
K
D
V
GR
A
H
R
V
S
AR
L
Q
Y
G
CT
WVN
THFMLVSEM
P
H
GG
Q
K
L
SG
Y
G
KDM
S
LYG
L
ED
Y
TVV
R
H
V
M
V
fig|444450.8.peg.2097
Escherichia coli O157:H7 str. EC4115 (1-472/474)
M
Q
HK
L
L
ING
ELVSG-EG
---
EKQPVY
NPAT
GDV
L
LEIAE
A
SAE
Q
V
D
A
AV
R
AA
DAA
F
--AE
W
GQTT
P
KV
R
AEC
L
L
K
LA
D
V
IE
ENGQ
V
F
A
E
LE
SR
N
C
GK
PLHSAFND
EI
PAIVDVFR
F
F
AG
AARCLN
G
LAAGEY
---
LEGHTSMI--R
R
D
PLGV
V
A
S
I
A
PWN
Y
P
LM
M
AA
WK
LA
PALAAGN
C
VV
L
KPSE
I
TPLTAL
KL
A
E
L
AK
DI
-
F
P
A
GV
I
NV
L
F
G
R
G
KTV
G
DP
LT
G
HP
K
V
RM
VS
L
TGS
IA
TG
E
H
I
ISH
T
-
A
P
S
IKR
T
H
M
ELGGK
A
P
V
IV
FD
D
-
AD
-----
I
E
A
V
VEGVRTFGYY
N
A
GQ
D
C
TVAC
R
I
YAQKGIY
D
T
L
VEKLGAAVATL
K
S
G
APDDES
-
TEL
GPL
S
S
L
AH
L
E
R
V
SKA
V
EE
A
KAT
G
H
IK
V
IT
G
G
--
EKRK
G
--
-
-
N
GY
YYA
PTL
LAGALQDDA
I
VQ
K
E
V
FGPV
V
S
V
TLFDNE
E
QV
V
NW
ANDSQYGL
A
S
S
V
W
T
K
D
V
GR
A
H
R
V
S
AR
L
Q
Y
G
CT
WVN
THFMLVSEM
P
H
GG
Q
K
L
SG
Y
G
KDM
S
LYG
L
ED
Y
TVV
R
H
V
M
V
fig|444451.5.peg.1978
Escherichia coli O157:H7 str. EC4196 (1-472/474)
M
Q
HK
L
L
ING
ELVSG-EG
---
EKQPVY
NPAT
GDV
L
LEIAE
A
SAE
Q
V
D
A
AV
R
AA
DAA
F
--AE
W
GQTT
P
KV
R
AEC
L
L
K
LA
D
V
IE
ENGQ
V
F
A
E
LE
SR
N
C
GK
PLHSAFND
EI
PAIVDVFR
F
F
AG
AARCLN
G
LAAGEY
---
LEGHTSMI--R
R
D
PLGV
V
A
S
I
A
PWN
Y
P
LM
M
AA
WK
LA
PALAAGN
C
VV
L
KPSE
I
TPLTAL
KL
A
E
L
AK
DI
-
F
P
A
GV
I
NV
L
F
G
R
G
KTV
G
DP
LT
G
HP
K
V
RM
VS
L
TGS
IA
TG
E
H
I
ISH
T
-
A
P
S
IKR
T
H
M
ELGGK
A
P
V
IV
FD
D
-
AD
-----
I
E
A
V
VEGVRTFGYY
N
A
GQ
D
C
TVAC
R
I
YAQKGIY
D
T
L
VEKLGAAVATL
K
S
G
APDDES
-
TEL
GPL
S
S
L
AH
L
E
R
V
SKA
V
EE
A
KAT
G
H
IK
V
IT
G
G
--
EKRK
G
--
-
-
N
GY
YYA
PTL
LAGALQDDA
I
VQ
K
E
V
FGPV
V
S
V
TLFDNE
E
QV
V
NW
ANDSQYGL
A
S
S
V
W
T
K
D
V
GR
A
H
R
V
S
AR
L
Q
Y
G
CT
WVN
THFMLVSEM
P
H
GG
Q
K
L
SG
Y
G
KDM
S
LYG
L
ED
Y
TVV
R
H
V
M
V
fig|444447.5.peg.5545
Escherichia coli O157:H7 str. EC4206 (1-472/474)
M
Q
HK
L
L
ING
ELVSG-EG
---
EKQPVY
NPAT
GDV
L
LEIAE
A
SAE
Q
V
D
A
AV
R
AA
DAA
F
--AE
W
GQTT
P
KV
R
AEC
L
L
K
LA
D
V
IE
ENGQ
V
F
A
E
LE
SR
N
C
GK
PLHSAFND
EI
PAIVDVFR
F
F
AG
AARCLN
G
LAAGEY
---
LEGHTSMI--R
R
D
PLGV
V
A
S
I
A
PWN
Y
P
LM
M
AA
WK
LA
PALAAGN
C
VV
L
KPSE
I
TPLTAL
KL
A
E
L
AK
DI
-
F
P
A
GV
I
NV
L
F
G
R
G
KTV
G
DP
LT
G
HP
K
V
RM
VS
L
TGS
IA
TG
E
H
I
ISH
T
-
A
P
S
IKR
T
H
M
ELGGK
A
P
V
IV
FD
D
-
AD
-----
I
E
A
V
VEGVRTFGYY
N
A
GQ
D
C
TVAC
R
I
YAQKGIY
D
T
L
VEKLGAAVATL
K
S
G
APDDES
-
TEL
GPL
S
S
L
AH
L
E
R
V
SKA
V
EE
A
KAT
G
H
IK
V
IT
G
G
--
EKRK
G
--
-
-
N
GY
YYA
PTL
LAGALQDDA
I
VQ
K
E
V
FGPV
V
S
V
TLFDNE
E
QV
V
NW
ANDSQYGL
A
S
S
V
W
T
K
D
V
GR
A
H
R
V
S
AR
L
Q
Y
G
CT
WVN
THFMLVSEM
P
H
GG
Q
K
L
SG
Y
G
KDM
S
LYG
L
ED
Y
TVV
R
H
V
M
V
fig|478004.5.peg.2821
Escherichia coli O157:H7 str. EC4401 (1-472/474)
M
Q
HK
L
L
ING
ELVSG-EG
---
EKQPVY
NPAT
GDV
L
LEIAE
A
SAE
Q
V
D
A
AV
R
AA
DAA
F
--AE
W
GQTT
P
KV
R
AEC
L
L
K
LA
D
V
IE
ENGQ
V
F
A
E
LE
SR
N
C
GK
PLHSAFND
EI
PAIVDVFR
F
F
AG
AARCLN
G
LAAGEY
---
LEGHTSMI--R
R
D
PLGV
V
A
S
I
A
PWN
Y
P
LM
M
AA
WK
LA
PALAAGN
C
VV
L
KPSE
I
TPLTAL
KL
A
E
L
AK
DI
-
F
P
A
GV
I
NV
L
F
G
R
G
KTV
G
DP
LT
G
HP
K
V
RM
VS
L
TGS
IA
TG
E
H
I
ISH
T
-
A
P
S
IKR
T
H
M
ELGGK
A
P
V
IV
FD
D
-
AD
-----
I
E
A
V
VEGVRTFGYY
N
A
GQ
D
C
TVAC
R
I
YAQKGIY
D
T
L
VEKLGAAVATL
K
S
G
APDDES
-
TEL
GPL
S
S
L
AH
L
E
R
V
SKA
V
EE
A
KAT
G
H
IK
V
IT
G
G
--
EKRK
G
--
-
-
N
GY
YYA
PTL
LAGALQDDA
I
VQ
K
E
V
FGPV
V
S
V
TLFDNE
E
QV
V
NW
ANDSQYGL
A
S
S
V
W
T
K
D
V
GR
A
H
R
V
S
AR
L
Q
Y
G
CT
WVN
THFMLVSEM
P
H
GG
Q
K
L
SG
Y
G
KDM
S
LYG
L
ED
Y
TVV
R
H
V
M
V
fig|478005.5.peg.2998
Escherichia coli O157:H7 str. EC4486 (1-472/474)
M
Q
HK
L
L
ING
ELVSG-EG
---
EKQPVY
NPAT
GDV
L
LEIAE
A
SAE
Q
V
D
A
AV
R
AA
DAA
F
--AE
W
GQTT
P
KV
R
AEC
L
L
K
LA
D
V
IE
ENGQ
V
F
A
E
LE
SR
N
C
GK
PLHSAFND
EI
PAIVDVFR
F
F
AG
AARCLN
G
LAAGEY
---
LEGHTSMI--R
R
D
PLGV
V
A
S
I
A
PWN
Y
P
LM
M
AA
WK
LA
PALAAGN
C
VV
L
KPSE
I
TPLTAL
KL
A
E
L
AK
DI
-
F
P
A
GV
I
NV
L
F
G
R
G
KTV
G
DP
LT
G
HP
K
V
RM
VS
L
TGS
IA
TG
E
H
I
ISH
T
-
A
P
S
IKR
T
H
M
ELGGK
A
P
V
IV
FD
D
-
AD
-----
I
E
A
V
VEGVRTFGYY
N
A
GQ
D
C
TVAC
R
I
YAQKGIY
D
T
L
VEKLGAAVATL
K
S
G
APDDES
-
TEL
GPL
S
S
L
AH
L
E
R
V
SKA
V
EE
A
KAT
G
H
IK
V
IT
G
G
--
EKRK
G
--
-
-
N
GY
YYA
PTL
LAGALQDDA
I
VQ
K
E
V
FGPV
V
S
V
TLFDNE
E
QV
V
NW
ANDSQYGL
A
S
S
V
W
T
K
D
V
GR
A
H
R
V
S
AR
L
Q
Y
G
CT
WVN
THFMLVSEM
P
H
GG
Q
K
L
SG
Y
G
KDM
S
LYG
L
ED
Y
TVV
R
H
V
M
V
fig|478006.5.peg.1969
Escherichia coli O157:H7 str. EC4501 (1-472/474)
M
Q
HK
L
L
ING
ELVSG-EG
---
EKQPVY
NPAT
GDV
L
LEIAE
A
SAE
Q
V
D
A
AV
R
AA
DAA
F
--AE
W
GQTT
P
KV
R
AEC
L
L
K
LA
D
V
IE
ENGQ
V
F
A
E
LE
SR
N
C
GK
PLHSAFND
EI
PAIVDVFR
F
F
AG
AARCLN
G
LAAGEY
---
LEGHTSMI--R
R
D
PLGV
V
A
S
I
A
PWN
Y
P
LM
M
AA
WK
LA
PALAAGN
C
VV
L
KPSE
I
TPLTAL
KL
A
E
L
AK
DI
-
F
P
A
GV
I
NV
L
F
G
R
G
KTV
G
DP
LT
G
HP
K
V
RM
VS
L
TGS
IA
TG
E
H
I
ISH
T
-
A
P
S
IKR
T
H
M
ELGGK
A
P
V
IV
FD
D
-
AD
-----
I
E
A
V
VEGVRTFGYY
N
A
GQ
D
C
TVAC
R
I
YAQKGIY
D
T
L
VEKLGAAVATL
K
S
G
APDDES
-
TEL
GPL
S
S
L
AH
L
E
R
V
SKA
V
EE
A
KAT
G
H
IK
V
IT
G
G
--
EKRK
G
--
-
-
N
GY
YYA
PTL
LAGALQDDA
I
VQ
K
E
V
FGPV
V
S
V
TLFDNE
E
QV
V
NW
ANDSQYGL
A
S
S
V
W
T
K
D
V
GR
A
H
R
V
S
AR
L
Q
Y
G
CT
WVN
THFMLVSEM
P
H
GG
Q
K
L
SG
Y
G
KDM
S
LYG
L
ED
Y
TVV
R
H
V
M
V
fig|478007.5.peg.2173
Escherichia coli O157:H7 str. EC508 (1-472/474)
M
Q
HK
L
L
ING
ELVSG-EG
---
EKQPVY
NPAT
GDV
L
LEIAE
A
SAE
Q
V
D
A
AV
R
AA
DAA
F
--AE
W
GQTT
P
KV
R
AEC
L
L
K
LA
D
V
IE
ENGQ
V
F
A
E
LE
SR
N
C
GK
PLHSAFND
EI
PAIVDVFR
F
F
AG
AARCLN
G
LAAGEY
---
LEGHTSMI--R
R
D
PLGV
V
A
S
I
A
PWN
Y
P
LM
M
AA
WK
LA
PALAAGN
C
VV
L
KPSE
I
TPLTAL
KL
A
E
L
AK
DI
-
F
P
A
GV
I
NV
L
F
G
R
G
KTV
G
DP
LT
G
HP
K
V
RM
VS
L
TGS
IA
TG
E
H
I
ISH
T
-
A
P
S
IKR
T
H
M
ELGGK
A
P
V
IV
FD
D
-
AD
-----
I
E
A
V
VEGVRTFGYY
N
A
GQ
D
C
TVAC
R
I
YAQKGIY
D
T
L
VEKLGAAVATL
K
S
G
APDDES
-
TEL
GPL
S
S
L
AH
L
E
R
V
SKA
V
EE
A
KAT
G
H
IK
V
IT
G
G
--
EKRK
G
--
-
-
N
GY
YYA
PTL
LAGALQDDA
I
VQ
K
E
V
FGPV
V
S
V
TLFDNE
E
QV
V
NW
ANDSQYGL
A
S
S
V
W
T
K
D
V
GR
A
H
R
V
S
AR
L
Q
Y
G
CT
WVN
THFMLVSEM
P
H
GG
Q
K
L
SG
Y
G
KDM
S
LYG
L
ED
Y
TVV
R
H
V
M
V
fig|478008.5.peg.3693
Escherichia coli O157:H7 str. EC869 (1-472/474)
M
Q
HK
L
L
ING
ELVSG-EG
---
EKQPVY
NPAT
GDV
L
LEIAE
A
SAE
Q
V
D
A
AV
R
AA
DAA
F
--AE
W
GQTT
P
KV
R
AEC
L
L
K
LA
D
V
IE
ENGQ
V
F
A
E
LE
SR
N
C
GK
PLHSAFND
EI
PAIVDVFR
F
F
AG
AARCLN
G
LAAGEY
---
LEGHTSMI--R
R
D
PLGV
V
A
S
I
A
PWN
Y
P
LM
M
AA
WK
LA
PALAAGN
C
VV
L
KPSE
I
TPLTAL
KL
A
E
L
AK
DI
-
F
P
A
GV
I
NV
L
F
G
R
G
KTV
G
DP
LT
G
HP
K
V
RM
VS
L
TGS
IA
TG
E
H
I
ISH
T
-
A
P
S
IKR
T
H
M
ELGGK
A
P
V
IV
FD
D
-
AD
-----
I
E
A
V
VEGVRTFGYY
N
A
GQ
D
C
TVAC
R
I
YAQKGIY
D
T
L
VEKLGAAVATL
K
S
G
APDDES
-
TEL
GPL
S
S
L
AH
L
E
R
V
SKA
V
EE
A
KAT
G
H
IK
V
IT
G
G
--
EKRK
G
--
-
-
N
GY
YYA
PTL
LAGALQDDA
I
VQ
K
E
V
FGPV
V
S
V
TLFDNE
E
QV
V
NW
ANDSQYGL
A
S
S
V
W
T
K
D
V
GR
A
H
R
V
S
AR
L
Q
Y
G
CT
WVN
THFMLVSEM
P
H
GG
Q
K
L
SG
Y
G
KDM
S
LYG
L
ED
Y
TVV
R
H
V
M
V
fig|637388.3.peg.1468
Escherichia coli O157:H7 str. FRIK2000 (1-472/474)
M
Q
HK
L
L
ING
ELVSG-EG
---
EKQPVY
NPAT
GDV
L
LEIAE
A
SAE
Q
V
D
A
AV
R
AA
DAA
F
--AE
W
GQTT
P
KV
R
AEC
L
L
K
LA
D
V
IE
ENGQ
V
F
A
E
LE
SR
N
C
GK
PLHSAFND
EI
PAIVDVFR
F
F
AG
AARCLN
G
LAAGEY
---
LEGHTSMI--R
R
D
PLGV
V
A
S
I
A
PWN
Y
P
LM
M
AA
WK
LA
PALAAGN
C
VV
L
KPSE
I
TPLTAL
KL
A
E
L
AK
DI
-
F
P
A
GV
I
NV
L
F
G
R
G
KTV
G
DP
LT
G
HP
K
V
RM
VS
L
TGS
IA
TG
E
H
I
ISH
T
-
A
P
S
IKR
T
H
M
ELGGK
A
P
V
IV
FD
D
-
AD
-----
I
E
A
V
VEGVRTFGYY
N
A
GQ
D
C
TVAC
R
I
YAQKGIY
D
T
L
VEKLGAAVATL
K
S
G
APDDES
-
TEL
GPL
S
S
L
AH
L
E
R
V
SKA
V
EE
A
KAT
G
H
IK
V
IT
G
G
--
EKRK
G
--
-
-
N
GY
YYA
PTL
LAGALQDDA
I
VQ
K
E
V
FGPV
V
S
V
TLFDNE
E
QV
V
NW
ANDSQYGL
A
S
S
V
W
T
K
D
V
GR
A
H
R
V
S
AR
L
Q
Y
G
CT
WVN
THFMLVSEM
P
H
GG
Q
K
L
SG
Y
G
KDM
S
LYG
L
ED
Y
TVV
R
H
V
M
V
fig|570506.3.peg.3245
Escherichia coli O157:H7 str. FRIK966 (1-472/474)
M
Q
HK
L
L
ING
ELVSG-EG
---
EKQPVY
NPAT
GDV
L
LEIAE
A
SAE
Q
V
D
A
AV
R
AA
DAA
F
--AE
W
GQTT
P
KV
R
AEC
L
L
K
LA
D
V
IE
ENGQ
V
F
A
E
LE
SR
N
C
GK
PLHSAFND
EI
PAIVDVFR
F
F
AG
AARCLN
G
LAAGEY
---
LEGHTSMI--R
R
D
PLGV
V
A
S
I
A
PWN
Y
P
LM
M
AA
WK
LA
PALAAGN
C
VV
L
KPSE
I
TPLTAL
KL
A
E
L
AK
DI
-
F
P
A
GV
I
NV
L
F
G
R
G
KTV
G
DP
LT
G
HP
K
V
RM
VS
L
TGS
IA
TG
E
H
I
ISH
T
-
A
P
S
IKR
T
H
M
ELGGK
A
P
V
IV
FD
D
-
AD
-----
I
E
A
V
VEGVRTFGYY
N
A
GQ
D
C
TVAC
R
I
YAQKGIY
D
T
L
VEKLGAAVATL
K
S
G
APDDES
-
TEL
GPL
S
S
L
AH
L
E
R
V
SKA
V
EE
A
KAT
G
H
IK
V
IT
G
G
--
EKRK
G
--
-
-
N
GY
YYA
PTL
LAGALQDDA
I
VQ
K
E
V
FGPV
V
S
V
TLFDNE
E
QV
V
NW
ANDSQYGL
A
S
S
V
W
T
K
D
V
GR
A
H
R
V
S
AR
L
Q
Y
G
CT
WVN
THFMLVSEM
P
H
GG
Q
K
L
SG
Y
G
KDM
S
LYG
L
ED
Y
TVV
R
H
V
M
V
fig|386585.9.peg.2148
Escherichia coli O157:H7 str. Sakai (1-472/474)
M
Q
HK
L
L
ING
ELVSG-EG
---
EKQPVY
NPAT
GDV
L
LEIAE
A
SAE
Q
V
D
A
AV
R
AA
DAA
F
--AE
W
GQTT
P
KV
R
AEC
L
L
K
LA
D
V
IE
ENGQ
V
F
A
E
LE
SR
N
C
GK
PLHSAFND
EI
PAIVDVFR
F
F
AG
AARCLN
G
LAAGEY
---
LEGHTSMI--R
R
D
PLGV
V
A
S
I
A
PWN
Y
P
LM
M
AA
WK
LA
PALAAGN
C
VV
L
KPSE
I
TPLTAL
KL
A
E
L
AK
DI
-
F
P
A
GV
I
NV
L
F
G
R
G
KTV
G
DP
LT
G
HP
K
V
RM
VS
L
TGS
IA
TG
E
H
I
ISH
T
-
A
P
S
IKR
T
H
M
ELGGK
A
P
V
IV
FD
D
-
AD
-----
I
E
A
V
VEGVRTFGYY
N
A
GQ
D
C
TVAC
R
I
YAQKGIY
D
T
L
VEKLGAAVATL
K
S
G
APDDES
-
TEL
GPL
S
S
L
AH
L
E
R
V
SKA
V
EE
A
KAT
G
H
IK
V
IT
G
G
--
EKRK
G
--
-
-
N
GY
YYA
PTL
LAGALQDDA
I
VQ
K
E
V
FGPV
V
S
V
TLFDNE
E
QV
V
NW
ANDSQYGL
A
S
S
V
W
T
K
D
V
GR
A
H
R
V
S
AR
L
Q
Y
G
CT
WVN
THFMLVSEM
P
H
GG
Q
K
L
SG
Y
G
KDM
S
LYG
L
ED
Y
TVV
R
H
V
M
V
fig|544404.4.peg.1959
Escherichia coli O157:H7 str. TW14359 (1-472/474)
M
Q
HK
L
L
ING
ELVSG-EG
---
EKQPVY
NPAT
GDV
L
LEIAE
A
SAE
Q
V
D
A
AV
R
AA
DAA
F
--AE
W
GQTT
P
KV
R
AEC
L
L
K
LA
D
V
IE
ENGQ
V
F
A
E
LE
SR
N
C
GK
PLHSAFND
EI
PAIVDVFR
F
F
AG
AARCLN
G
LAAGEY
---
LEGHTSMI--R
R
D
PLGV
V
A
S
I
A
PWN
Y
P
LM
M
AA
WK
LA
PALAAGN
C
VV
L
KPSE
I
TPLTAL
KL
A
E
L
AK
DI
-
F
P
A
GV
I
NV
L
F
G
R
G
KTV
G
DP
LT
G
HP
K
V
RM
VS
L
TGS
IA
TG
E
H
I
ISH
T
-
A
P
S
IKR
T
H
M
ELGGK
A
P
V
IV
FD
D
-
AD
-----
I
E
A
V
VEGVRTFGYY
N
A
GQ
D
C
TVAC
R
I
YAQKGIY
D
T
L
VEKLGAAVATL
K
S
G
APDDES
-
TEL
GPL
S
S
L
AH
L
E
R
V
SKA
V
EE
A
KAT
G
H
IK
V
IT
G
G
--
EKRK
G
--
-
-
N
GY
YYA
PTL
LAGALQDDA
I
VQ
K
E
V
FGPV
V
S
V
TLFDNE
E
QV
V
NW
ANDSQYGL
A
S
S
V
W
T
K
D
V
GR
A
H
R
V
S
AR
L
Q
Y
G
CT
WVN
THFMLVSEM
P
H
GG
Q
K
L
SG
Y
G
KDM
S
LYG
L
ED
Y
TVV
R
H
V
M
V
fig|502346.5.peg.5324
Escherichia coli O157:H7 str. TW14588 (1-472/474)
M
Q
HK
L
L
ING
ELVSG-EG
---
EKQPVY
NPAT
GDV
L
LEIAE
A
SAE
Q
V
D
A
AV
R
AA
DAA
F
--AE
W
GQTT
P
KV
R
AEC
L
L
K
LA
D
V
IE
ENGQ
V
F
A
E
LE
SR
N
C
GK
PLHSAFND
EI
PAIVDVFR
F
F
AG
AARCLN
G
LAAGEY
---
LEGHTSMI--R
R
D
PLGV
V
A
S
I
A
PWN
Y
P
LM
M
AA
WK
LA
PALAAGN
C
VV
L
KPSE
I
TPLTAL
KL
A
E
L
AK
DI
-
F
P
A
GV
I
NV
L
F
G
R
G
KTV
G
DP
LT
G
HP
K
V
RM
VS
L
TGS
IA
TG
E
H
I
ISH
T
-
A
P
S
IKR
T
H
M
ELGGK
A
P
V
IV
FD
D
-
AD
-----
I
E
A
V
VEGVRTFGYY
N
A
GQ
D
C
TVAC
R
I
YAQKGIY
D
T
L
VEKLGAAVATL
K
S
G
APDDES
-
TEL
GPL
S
S
L
AH
L
E
R
V
SKA
V
EE
A
KAT
G
H
IK
V
IT
G
G
--
EKRK
G
--
-
-
N
GY
YYA
PTL
LAGALQDDA
I
VQ
K
E
V
FGPV
V
S
V
TLFDNE
E
QV
V
NW
ANDSQYGL
A
S
S
V
W
T
K
D
V
GR
A
H
R
V
S
AR
L
Q
Y
G
CT
WVN
THFMLVSEM
P
H
GG
Q
K
L
SG
Y
G
KDM
S
LYG
L
ED
Y
TVV
R
H
V
M
V
fig|656419.3.peg.2016
Escherichia coli M718 (1-472/474)
M
Q
HK
L
L
ING
ELVSG-EG
---
EKQPVY
NPAT
GDV
L
LEIAE
A
SAE
Q
V
D
A
AV
R
AA
DAA
F
--AE
W
GQTT
P
KV
R
AEC
L
L
K
LA
D
V
IE
ENGQ
V
F
A
E
LE
SR
N
C
GK
PLHSAFND
EI
PAIVDVFR
F
F
AG
AARCLN
G
LAAGEY
---
LEGHTSMI--R
R
D
PLGV
V
A
S
I
A
PWN
Y
P
LM
M
AA
WK
LA
PALAAGN
C
VV
L
KPSE
I
TPLTAL
KL
A
E
L
AK
DI
-
F
P
A
GV
I
NV
L
F
G
R
G
KTV
G
DP
LT
G
HP
K
V
RM
VS
L
TGS
IA
TG
E
H
I
ISH
T
-
A
P
S
IKR
T
H
M
ELGGK
A
P
V
IV
FD
D
-
A
N
-----
I
E
A
V
VEGVRTFGYY
N
A
GQ
D
C
TAAC
R
I
YAQKGIY
D
T
L
VEKLGAAVATL
K
S
G
APDDES
-
TEL
GPL
S
S
L
AH
L
E
R
V
SKA
V
EE
A
KAT
G
H
IK
V
IT
G
G
--
EKRK
G
--
-
-
N
GY
YYA
PTL
LAGALQDDA
I
VQ
K
E
V
FGPV
V
S
V
TPFDNE
E
QV
V
NW
ANDSQYGL
A
S
S
V
W
T
K
D
V
GR
A
H
R
V
S
AR
L
Q
Y
G
CT
WVN
THFMLVSEM
P
H
GG
Q
K
L
SG
Y
G
KDM
S
LYG
L
ED
Y
TVV
R
H
V
M
V
fig|562.375.peg.4329
Escherichia coli EC4100B (1-472/474)
M
Q
HK
L
L
ING
ELVSG-EG
---
EKQPVY
NPAT
GDV
L
LEIAE
A
SAE
Q
V
D
A
AV
R
AA
DAA
F
--AE
W
GQTT
P
KV
R
AEC
L
L
K
LA
D
V
IE
ENGQ
V
F
A
E
LE
SR
N
C
GK
PLHSAFND
EI
PAVVDVFR
F
F
AG
AARCLN
G
LAAGEY
---
LEGHTSMN--R
R
D
PLGV
V
A
S
I
A
PWN
Y
P
LM
M
AA
WK
LA
PALAAGN
C
VV
L
KPSE
I
TPLTAL
KL
A
E
L
AK
DI
-
F
P
A
GV
I
N
I
L
F
G
R
G
KTV
G
DP
LT
G
HP
K
V
RM
VS
L
TGS
IA
TG
E
H
I
ISH
T
-
A
S
S
IKR
T
H
M
ELGGK
A
P
V
IV
FD
D
-
AD
-----
I
E
A
V
VEGVRTFGYY
N
A
GQ
D
C
TAAC
R
I
YAQKGIY
D
T
L
VEKLGAAVATL
K
S
G
APDDES
-
TEL
GPL
S
S
L
AH
L
E
R
V
SKA
V
EE
A
KAT
G
H
IK
V
IT
G
G
--
EKRK
G
--
-
-
N
GY
YYA
PTL
LAGALQDDA
I
VQ
K
E
V
FGPV
V
S
V
TLFDNE
E
QV
V
NW
ANDSQYGL
A
S
S
V
W
T
K
D
V
GR
A
H
R
V
S
AR
L
Q
Y
G
CT
WVN
THFMLVSEM
P
H
GG
Q
K
L
SG
Y
G
KDM
S
LYG
L
ED
Y
TVV
R
H
V
M
V
fig|670897.3.peg.4930
Escherichia coli 2362-75 (1-477/479)
M
S
VPV
Q
HP
M
Y
I
D
G
QFVTWRGD
---
AWIDVV
NPAT
EAV
I
SRIPD
G
QAE
D
A
R
K
A
I
D
AA
ERA
Q
--PE
W
EALP
A
IE
R
ASW
L
R
K
IS
D
G
I
R
ERAS
E
I
S
A
L
I
VE
E
G
GK
-IQQLAEV
E
V
AFTADYID
Y
M
A
E
WARRYE
G
EIIQSD
---
--RPGENILLF
K
R
A
LGV
T
T
G
I
L
PWNFP
FF
L
IA
R
K
MA
PAL
LT
GN
T
I
V
I
KPSE
F
TP
N
N
A
I
AF
A
K
I
VD
E
I
G
L
P
R
GV
F
N
L
V
L
G
R
G
ETV
G
QE
L
A
G
N
P
K
V
AM
VS
M
TGS
VS
A
G
E
K
I
MAT
A
-
A
K
NI
T
K
V
C
LELGGK
A
P
A
IV
MD
D
-
AD
-----
L
E
L
A
VKAIFDSRVI
N
S
GQVC
NCAE
RV
YVQKSIY
D
Q
F
VNRLGEAMQAV
Q
F
G
NPAERN
D
IAM
GPL
I
N
A
A
A
L
E
R
V
EQK
V
AR
A
VEE
G
-
AR
V
AL
G
G
--
KAVE
G
--
-
-
K
GY
YYP
PTL
LLDVRQEMS
I
MH
EE
T
FGPVL
P
V
VAFDTL
EEAI
SM
ANDS
D
YGL
T
S
S
I
Y
T
Q
N
L
NV
A
M
K
A
I
KG
LK
F
G
ET
Y
I
N
RENFEAMQG
F
H
A
G
W
R
K
SG
I
G
GAD
G
KHG
L
HE
Y
LQT
Q
V
V
Y
L
fig|216593.1.peg.2010
Escherichia coli E2348/69 (1-477/479)
M
S
VPV
Q
HP
M
Y
I
D
G
QFVTWRGD
---
AWIDVV
NPAT
EAV
I
SRIPD
G
QAE
D
A
R
K
A
I
D
AA
ERA
Q
--PE
W
EALP
A
IE
R
ASW
L
R
K
IS
D
G
I
R
ERAS
E
I
S
A
L
I
VE
E
G
GK
-IQQLAEV
E
V
AFTADYID
Y
M
A
E
WARRYE
G
EIIQSD
---
--RPGENILLF
K
R
A
LGV
T
T
G
I
L
PWNFP
FF
L
IA
R
K
MA
PAL
LT
GN
T
I
V
I
KPSE
F
TP
N
N
A
I
AF
A
K
I
VD
E
I
G
L
P
R
GV
F
N
L
V
L
G
R
G
ETV
G
QE
L
A
G
N
P
K
V
AM
VS
M
TGS
VS
A
G
E
K
I
MAT
A
-
A
K
NI
T
K
V
C
LELGGK
A
P
A
IV
MD
D
-
AD
-----
L
E
L
A
VKAIFDSRVI
N
S
GQVC
NCAE
RV
YVQKSIY
D
Q
F
VNRLGEAMQAV
Q
F
G
NPAERN
D
IAM
GPL
I
N
A
A
A
L
E
R
V
EQK
V
AR
A
VEE
G
-
AR
V
AL
G
G
--
KAVE
G
--
-
-
K
GY
YYP
PTL
LLDVRQEMS
I
MH
EE
T
FGPVL
P
V
VAFDTL
EEAI
SM
ANDS
D
YGL
T
S
S
I
Y
T
Q
N
L
NV
A
M
K
A
I
KG
LK
F
G
ET
Y
I
N
RENFEAMQG
F
H
A
G
W
R
K
SG
I
G
GAD
G
KHG
L
HE
Y
LQT
Q
V
V
Y
L
fig|753642.3.peg.1746
Escherichia coli NC101 (1-477/479)
M
S
VPV
Q
HP
M
Y
I
D
G
QFVTWRGD
---
AWIDVV
NPAT
EVV
I
SRIPD
G
QAE
D
A
R
K
A
I
D
AA
ERA
Q
--PE
W
EALP
A
IE
R
ASW
L
R
K
IS
A
G
I
R
ERAS
E
I
S
A
L
I
VE
E
G
S
K
-IQQLAEV
E
V
AFTADYID
Y
M
A
E
WARRYE
G
EIIQSD
---
--RPGENILLF
K
R
A
LGV
T
T
G
I
L
PWNFP
FF
L
IA
R
K
MA
PAL
LT
GN
T
I
V
I
KPSE
F
TP
N
N
A
I
AL
A
K
I
VD
E
I
G
L
P
R
GV
F
N
L
V
L
G
R
G
ETV
G
QE
L
A
G
N
P
K
V
AM
VS
M
TGS
VS
A
G
E
K
I
MAT
A
-
A
K
NI
T
K
V
C
LELGGK
A
P
A
IV
MD
D
-
AD
-----
L
E
L
A
VKAIVDSRVI
N
S
GQVC
NCAE
RV
YVQKSIY
D
Q
F
VNRLGEAMQAV
Q
F
G
NPAERN
D
IAM
GPL
I
N
A
A
A
L
E
R
V
EQK
V
AR
A
VEE
G
-
AR
V
AL
G
G
--
KAVE
G
--
-
-
K
GY
YYP
PTL
LLDVRQEMS
I
MH
EE
T
FGPVL
P
V
VAFDTL
EEAI
SM
ANDS
D
YGL
T
S
S
I
Y
T
Q
N
L
NV
A
M
K
A
I
KG
LK
F
G
ET
Y
I
N
RENFEAMQG
F
H
A
G
W
R
K
SG
I
G
GAD
G
KHG
L
HE
Y
LQT
Q
V
V
Y
L
fig|656440.3.peg.1282
Escherichia coli TA206 (1-477/479)
M
S
VPV
Q
HP
M
Y
I
D
G
QFVTWRGD
---
AWIDVV
NPAT
EAV
I
SRIPD
G
QAE
D
A
R
K
A
I
D
AA
ERA
Q
--PE
W
EALP
A
IE
R
ASW
L
R
K
IS
A
G
I
R
ERAS
E
I
S
A
L
I
VE
E
G
GK
-IQQLAEV
E
V
AFTADYID
Y
M
A
E
WARRYE
G
EIIQSD
---
--RPGENILLF
K
R
A
LGV
T
T
G
I
L
PWNFP
FF
L
IA
R
K
MA
PAL
LT
GN
T
I
V
I
KPSE
F
TP
N
N
A
I
AF
A
K
I
VD
E
I
G
L
P
R
GV
F
N
L
V
L
G
R
G
ETV
G
QE
L
A
G
N
P
K
V
AM
VS
M
TGS
VS
A
G
E
K
I
MAT
A
-
A
K
NI
T
K
V
C
LELGGK
A
P
A
IV
MD
D
-
AD
-----
L
E
L
A
VKAIVDSRVI
N
S
GQVC
NCAE
RV
YVQKSIY
D
Q
F
VNRLGEAMQAV
Q
F
G
NPAERN
D
IAM
GPL
I
N
A
A
A
L
E
R
V
EQK
V
AR
A
VEE
G
-
AR
V
AL
G
G
--
KAVE
G
--
-
-
K
GY
YYP
PTL
LLDVRQEMS
I
MH
EE
T
FGPVL
P
V
VAFDTL
EEAI
SM
ANDS
D
YGL
T
S
S
I
Y
T
Q
N
L
NV
A
M
K
A
I
KG
LK
F
G
ET
Y
I
N
RENFEAMQG
F
H
A
G
W
R
K
SG
I
G
GAD
G
KHG
L
HE
Y
LQT
Q
V
V
Y
L
fig|199310.1.peg.1786
Escherichia coli CFT073 (1-477/479)
M
S
VPV
Q
HP
M
Y
I
D
G
QFVTWRGD
---
AWIDVV
NPAT
EAV
I
SRIPD
G
QAE
D
A
R
K
A
I
D
AA
ERA
Q
--PE
W
EALP
A
IE
R
ASW
L
R
K
IS
A
G
I
R
ERAT
E
I
S
A
L
I
VE
E
G
GK
-IQQLAEV
E
V
AFTADYID
Y
M
A
E
WARRYE
G
EIIQSD
---
--RPGENILLF
K
R
A
LGV
T
T
G
I
L
PWNFP
FF
L
IA
R
K
MA
PAL
LT
GN
T
I
V
I
KPSE
F
TP
N
N
A
I
AF
A
K
I
VD
E
I
G
L
P
R
GV
F
N
L
V
L
G
R
G
ETV
G
QE
L
A
G
N
P
K
V
AM
VS
M
TGS
VS
A
G
E
K
I
MAT
A
-
A
K
NI
T
K
V
C
LELGGK
A
P
A
IV
MD
D
-
AD
-----
L
E
L
A
VKAIVDSRVI
N
S
GQVC
NCAE
RV
YVQKSIY
D
Q
F
VNRLGEAMQAV
Q
F
G
NPAERN
D
IAM
GPL
I
N
A
A
A
L
E
R
V
EQK
V
AR
A
VEE
G
-
AR
V
AL
G
G
--
KAVE
G
--
-
-
K
GY
YYP
PTL
LLDVRQEMS
I
MH
EE
T
FGPVL
P
V
VAFDTL
EEAI
SM
ANDS
D
YGL
T
S
S
I
Y
T
Q
N
L
NV
A
M
K
A
I
KG
LK
F
G
ET
Y
I
N
RENFEAMQG
F
H
A
G
W
R
K
SG
I
G
GAD
G
KHG
L
HE
Y
LQT
Q
V
V
Y
L
fig|199310.4.peg.1716
Escherichia coli CFT073 (1-477/479)
M
S
VPV
Q
HP
M
Y
I
D
G
QFVTWRGD
---
AWIDVV
NPAT
EAV
I
SRIPD
G
QAE
D
A
R
K
A
I
D
AA
ERA
Q
--PE
W
EALP
A
IE
R
ASW
L
R
K
IS
A
G
I
R
ERAT
E
I
S
A
L
I
VE
E
G
GK
-IQQLAEV
E
V
AFTADYID
Y
M
A
E
WARRYE
G
EIIQSD
---
--RPGENILLF
K
R
A
LGV
T
T
G
I
L
PWNFP
FF
L
IA
R
K
MA
PAL
LT
GN
T
I
V
I
KPSE
F
TP
N
N
A
I
AF
A
K
I
VD
E
I
G
L
P
R
GV
F
N
L
V
L
G
R
G
ETV
G
QE
L
A
G
N
P
K
V
AM
VS
M
TGS
VS
A
G
E
K
I
MAT
A
-
A
K
NI
T
K
V
C
LELGGK
A
P
A
IV
MD
D
-
AD
-----
L
E
L
A
VKAIVDSRVI
N
S
GQVC
NCAE
RV
YVQKSIY
D
Q
F
VNRLGEAMQAV
Q
F
G
NPAERN
D
IAM
GPL
I
N
A
A
A
L
E
R
V
EQK
V
AR
A
VEE
G
-
AR
V
AL
G
G
--
KAVE
G
--
-
-
K
GY
YYP
PTL
LLDVRQEMS
I
MH
EE
T
FGPVL
P
V
VAFDTL
EEAI
SM
ANDS
D
YGL
T
S
S
I
Y
T
Q
N
L
NV
A
M
K
A
I
KG
LK
F
G
ET
Y
I
N
RENFEAMQG
F
H
A
G
W
R
K
SG
I
G
GAD
G
KHG
L
HE
Y
LQT
Q
V
V
Y
L
fig|749546.3.peg.727
Escherichia coli MS 185-1 (1-477/479)
M
S
VPV
Q
HP
M
Y
I
D
G
QFVTWRGD
---
AWIDVV
NPAT
EAV
I
SRIPD
G
QAE
D
A
R
K
A
I
D
AA
ERA
Q
--PE
W
EALP
A
IE
R
ASW
L
R
K
IS
A
G
I
R
ERAT
E
I
S
A
L
I
VE
E
G
GK
-IQQLAEV
E
V
AFTADYID
Y
M
A
E
WARRYE
G
EIIQSD
---
--RPGENILLF
K
R
A
LGV
T
T
G
I
L
PWNFP
FF
L
IA
R
K
MA
PAL
LT
GN
T
I
V
I
KPSE
F
TP
N
N
A
I
AF
A
K
I
VD
E
I
G
L
P
R
GV
F
N
L
V
L
G
R
G
ETV
G
QE
L
A
G
N
P
K
V
AM
VS
M
TGS
VS
A
G
E
K
I
MAT
A
-
A
K
NI
T
K
V
C
LELGGK
A
P
A
IV
MD
D
-
AD
-----
L
E
L
A
VKAIVDSRVI
N
S
GQVC
NCAE
RV
YVQKSIY
D
Q
F
VNRLGEAMQAV
Q
F
G
NPAERN
D
IAM
GPL
I
N
A
A
A
L
E
R
V
EQK
V
AR
A
VEE
G
-
AR
V
AL
G
G
--
KAVE
G
--
-
-
K
GY
YYP
PTL
LLDVRQEMS
I
MH
EE
T
FGPVL
P
V
VAFDTL
EEAI
SM
ANDS
D
YGL
T
S
S
I
Y
T
Q
N
L
NV
A
M
K
A
I
KG
LK
F
G
ET
Y
I
N
RENFEAMQG
F
H
A
G
W
R
K
SG
I
G
GAD
G
KHG
L
HE
Y
LQT
Q
V
V
Y
L
fig|749528.3.peg.1165
Escherichia coli MS 45-1 (1-477/479)
M
S
VPV
Q
HP
M
Y
I
D
G
QFVTWRGD
---
AWIDVV
NPAT
EAV
I
SRIPD
G
QAE
D
A
R
K
A
I
D
AA
ERA
Q
--PE
W
EALP
A
IE
R
ASW
L
R
K
IS
A
G
I
R
ERAT
E
I
S
A
L
I
VE
E
G
GK
-IQQLAEV
E
V
AFTADYID
Y
M
A
E
WARRYE
G
EIIQSD
---
--RPGENILLF
K
R
A
LGV
T
T
G
I
L
PWNFP
FF
L
IA
R
K
MA
PAL
LT
GN
T
I
V
I
KPSE
F
TP
N
N
A
I
AF
A
K
I
VD
E
I
G
L
P
R
GV
F
N
L
V
L
G
R
G
ETV
G
QE
L
A
G
N
P
K
V
AM
VS
M
TGS
VS
A
G
E
K
I
MAT
A
-
A
K
NI
T
K
V
C
LELGGK
A
P
A
IV
MD
D
-
AD
-----
L
E
L
A
VKAIVDSRVI
N
S
GQVC
NCAE
RV
YVQKSIY
D
Q
F
VNRLGEAMQAV
Q
F
G
NPAERN
D
IAM
GPL
I
N
A
A
A
L
E
R
V
EQK
V
AR
A
VEE
G
-
AR
V
AL
G
G
--
KAVE
G
--
-
-
K
GY
YYP
PTL
LLDVRQEMS
I
MH
EE
T
FGPVL
P
V
VAFDTL
EEAI
SM
ANDS
D
YGL
T
S
S
I
Y
T
Q
N
L
NV
A
M
K
A
I
KG
LK
F
G
ET
Y
I
N
RENFEAMQG
F
H
A
G
W
R
K
SG
I
G
GAD
G
KHG
L
HE
Y
LQT
Q
V
V
Y
L
fig|340186.3.peg.230
Escherichia coli E110019 (1-477/479)
M
S
VPV
Q
HP
M
Y
I
D
G
QFVTWRGD
---
AWIDVV
NPAT
EAV
I
SRIPD
G
QAE
D
A
R
K
A
I
D
AA
ERA
Q
--PE
W
EALP
A
IE
R
ASW
L
R
K
IS
A
G
I
R
ERAS
E
I
S
A
L
I
VE
E
G
GK
-IQQLAEV
E
V
AFTADYID
Y
M
A
E
WARRYE
G
EIIQSD
---
--RPGENILLF
K
R
A
LGV
T
T
G
I
L
PWNFP
FF
L
IA
R
K
MA
PAL
LT
GN
T
I
V
I
KPSE
F
TP
N
N
A
I
AF
A
K
I
VD
E
I
G
L
P
R
GV
F
N
L
V
L
G
R
G
ETV
G
QE
L
A
G
N
S
K
V
AM
VS
M
TGS
VS
A
G
E
K
I
MAT
A
-
A
K
NI
T
K
V
C
LELGGK
A
P
A
IV
MD
D
-
AD
-----
L
E
L
A
VKAIVDSRVI
N
S
GQVC
NCAE
R
I
YVQKGIY
D
Q
F
VNRLGEAMQAV
Q
F
G
NPAERN
D
IAM
GPL
I
N
A
A
A
L
E
R
V
EQK
V
AR
A
VEE
G
-
AR
V
AL
G
G
--
KAVE
G
--
-
-
K
GY
YYP
PTL
LLDVRQEMS
I
MH
EE
T
FGPVL
P
V
VAFDTL
EEAI
SM
ANDS
D
YGL
T
S
S
I
Y
T
Q
N
L
NV
A
M
K
A
I
KG
LK
F
G
ET
Y
I
N
RENFEAMQG
F
H
A
G
W
R
K
SG
I
G
GAD
G
KHG
L
HE
Y
LQT
Q
V
V
Y
L
fig|340186.5.peg.246
Escherichia coli E110019 (1-477/479)
M
S
VPV
Q
HP
M
Y
I
D
G
QFVTWRGD
---
AWIDVV
NPAT
EAV
I
SRIPD
G
QAE
D
A
R
K
A
I
D
AA
ERA
Q
--PE
W
EALP
A
IE
R
ASW
L
R
K
IS
A
G
I
R
ERAS
E
I
S
A
L
I
VE
E
G
GK
-IQQLAEV
E
V
AFTADYID
Y
M
A
E
WARRYE
G
EIIQSD
---
--RPGENILLF
K
R
A
LGV
T
T
G
I
L
PWNFP
FF
L
IA
R
K
MA
PAL
LT
GN
T
I
V
I
KPSE
F
TP
N
N
A
I
AF
A
K
I
VD
E
I
G
L
P
R
GV
F
N
L
V
L
G
R
G
ETV
G
QE
L
A
G
N
S
K
V
AM
VS
M
TGS
VS
A
G
E
K
I
MAT
A
-
A
K
NI
T
K
V
C
LELGGK
A
P
A
IV
MD
D
-
AD
-----
L
E
L
A
VKAIVDSRVI
N
S
GQVC
NCAE
R
I
YVQKGIY
D
Q
F
VNRLGEAMQAV
Q
F
G
NPAERN
D
IAM
GPL
I
N
A
A
A
L
E
R
V
EQK
V
AR
A
VEE
G
-
AR
V
AL
G
G
--
KAVE
G
--
-
-
K
GY
YYP
PTL
LLDVRQEMS
I
MH
EE
T
FGPVL
P
V
VAFDTL
EEAI
SM
ANDS
D
YGL
T
S
S
I
Y
T
Q
N
L
NV
A
M
K
A
I
KG
LK
F
G
ET
Y
I
N
RENFEAMQG
F
H
A
G
W
R
K
SG
I
G
GAD
G
KHG
L
HE
Y
LQT
Q
V
V
Y
L
fig|585397.7.peg.1584
Escherichia coli ED1a (1-477/479)
M
S
VPV
Q
HP
M
Y
I
D
G
QFVTWRGD
---
AWIDVV
NPAT
EAV
I
SRIPD
G
QAE
D
A
R
K
A
I
D
AA
ERA
Q
--PE
W
EALP
A
IE
R
ASW
L
R
K
IS
A
G
I
R
ERAS
E
I
S
A
L
I
VE
E
G
GK
-IQQLAEV
E
V
AFTADYID
Y
M
A
E
WARRYD
G
EIIQSD
---
--RPGENILLF
K
R
A
LGV
T
T
G
I
L
PWNFP
FF
L
IA
R
K
MA
PAL
LT
GN
T
I
V
I
KPSE
F
TP
N
N
A
I
AF
A
K
I
VD
E
I
G
L
P
R
GV
F
N
L
V
L
G
R
G
ETV
G
QE
L
A
G
N
P
K
V
AM
VS
M
TGS
VS
A
G
E
K
I
MAT
A
-
A
K
NI
T
K
V
C
LELGGK
A
P
A
IV
MD
D
-
AD
-----
L
E
L
A
VKAIVDSRVI
N
S
GQVC
NCAE
RV
YVQKSIY
D
Q
F
VNRLGEAMQAV
Q
F
G
NPAERN
D
IAM
GPL
I
N
A
A
A
L
E
R
V
EQK
V
AR
A
VEE
G
-
AR
V
AL
G
G
--
KAVE
G
--
-
-
K
GY
YYP
PTL
LLDVRQEMS
I
MH
EE
T
FGPVL
P
V
VAFDTL
EEAI
SM
ANDS
D
YGL
T
S
S
I
Y
T
Q
N
L
NV
A
M
K
A
I
KG
LK
F
G
ET
Y
I
N
RENFEAMQG
F
H
A
G
W
R
K
SG
I
G
GAD
G
KHG
L
HE
Y
LQT
Q
V
V
Y
L
fig|585397.9.peg.1577
Escherichia coli ED1a (1-477/479)
M
S
VPV
Q
HP
M
Y
I
D
G
QFVTWRGD
---
AWIDVV
NPAT
EAV
I
SRIPD
G
QAE
D
A
R
K
A
I
D
AA
ERA
Q
--PE
W
EALP
A
IE
R
ASW
L
R
K
IS
A
G
I
R
ERAS
E
I
S
A
L
I
VE
E
G
GK
-IQQLAEV
E
V
AFTADYID
Y
M
A
E
WARRYD
G
EIIQSD
---
--RPGENILLF
K
R
A
LGV
T
T
G
I
L
PWNFP
FF
L
IA
R
K
MA
PAL
LT
GN
T
I
V
I
KPSE
F
TP
N
N
A
I
AF
A
K
I
VD
E
I
G
L
P
R
GV
F
N
L
V
L
G
R
G
ETV
G
QE
L
A
G
N
P
K
V
AM
VS
M
TGS
VS
A
G
E
K
I
MAT
A
-
A
K
NI
T
K
V
C
LELGGK
A
P
A
IV
MD
D
-
AD
-----
L
E
L
A
VKAIVDSRVI
N
S
GQVC
NCAE
RV
YVQKSIY
D
Q
F
VNRLGEAMQAV
Q
F
G
NPAERN
D
IAM
GPL
I
N
A
A
A
L
E
R
V
EQK
V
AR
A
VEE
G
-
AR
V
AL
G
G
--
KAVE
G
--
-
-
K
GY
YYP
PTL
LLDVRQEMS
I
MH
EE
T
FGPVL
P
V
VAFDTL
EEAI
SM
ANDS
D
YGL
T
S
S
I
Y
T
Q
N
L
NV
A
M
K
A
I
KG
LK
F
G
ET
Y
I
N
RENFEAMQG
F
H
A
G
W
R
K
SG
I
G
GAD
G
KHG
L
HE
Y
LQT
Q
V
V
Y
L
fig|562.376.peg.3089
Escherichia coli WV_060327 (1-477/479)
M
S
VPV
Q
HP
M
Y
I
D
G
QFVTWRGD
---
AWIDVV
NPAT
EAV
I
SRIPD
G
QAE
D
A
R
K
A
I
D
AA
ERA
Q
--PE
W
EALP
A
IE
R
ASW
L
R
K
IS
A
G
I
R
ERAS
E
I
S
A
L
I
VE
E
G
GK
-IQQLAEV
E
V
AFTADYID
Y
M
A
E
WARRYE
G
EIIQSD
---
--RPGENILLF
K
R
A
LGV
T
T
G
I
L
PWNFP
FF
L
IA
R
K
MA
PAL
LT
GN
T
I
V
I
KPSE
F
TP
N
N
A
I
AF
A
K
I
VD
E
I
G
L
P
R
GV
F
N
L
V
L
G
R
G
ETV
G
QE
L
A
G
N
P
K
V
AM
VS
M
TGS
VS
A
G
E
K
I
MAT
A
-
A
K
NI
T
K
V
C
LELGGK
A
P
A
IV
MD
D
-
AD
-----
I
E
L
A
VKAIVDSRVI
N
S
GQVC
NCAE
RV
YVQKSIY
D
Q
F
VNRLGEAMQAV
Q
F
G
NPAERN
D
IAM
GPL
I
N
A
A
A
L
E
R
V
EQK
V
AR
A
VEE
G
-
AR
V
AL
G
G
--
KAVE
G
--
-
-
K
GY
YYP
PTL
LLDVRQEMS
I
MH
EE
T
FGPVL
P
V
VAFDTL
EEAI
SM
ANDS
D
YGL
T
S
S
I
Y
T
K
N
L
NV
A
M
K
A
I
KG
LK
F
G
ET
Y
I
N
RENFEAMQG
F
H
A
G
W
R
K
SG
I
G
GAD
G
KHG
L
HE
Y
LQT
Q
V
V
Y
L
fig|562.375.peg.4296
Escherichia coli EC4100B (1-477/479)
M
S
VPV
Q
HP
M
Y
I
D
G
QFVTWRGD
---
AWIDVV
NPAT
EAV
I
SRIPD
G
QAE
D
A
R
K
A
I
D
AA
ERA
Q
--PE
W
EALP
A
IE
R
ASW
L
R
K
IS
A
G
I
R
ERAS
E
I
S
A
L
I
VE
E
G
GK
-IQQLAEV
E
V
AFTADYID
Y
M
A
E
WARRYE
G
EIIQSD
---
--RPGENILLF
K
R
A
LGV
T
T
G
I
L
PWNFP
FF
L
IA
R
K
MA
PAL
LT
GN
T
I
V
I
KPSE
F
TP
TN
A
I
AF
A
K
I
VD
E
I
G
L
P
R
GV
F
N
L
V
L
G
R
G
ETV
G
QE
L
A
G
N
P
K
V
AM
VS
M
TGS
VS
A
G
E
K
I
MAT
A
-
A
K
NI
T
K
V
C
LELGGK
A
P
A
IV
MD
D
-
AD
-----
L
E
L
A
VKAIVDSRVI
N
S
GQVC
NCAE
R
I
YVQKGIY
D
Q
F
VNRLGEAMQAV
Q
F
G
NPAERN
D
IAM
GPL
I
N
A
A
A
L
E
R
V
EQK
V
AR
A
VEE
G
-
AR
V
AL
G
G
--
KAVE
G
--
-
-
K
GY
YYP
PTL
LLDVRQEMS
I
MH
EE
T
FGPVL
P
V
VAFDTL
EEAI
SM
ANDS
D
YGL
T
S
S
I
Y
T
Q
N
L
NV
A
M
K
A
I
KG
LK
F
G
ET
Y
I
N
RENFEAMQG
F
H
A
G
W
R
K
SG
I
G
GAD
G
KHG
L
HE
Y
LQT
Q
V
V
Y
L
fig|656408.3.peg.1546
Escherichia coli H591 (1-477/479)
M
S
VPV
Q
HP
M
Y
I
D
G
QFVTWRGD
---
AWIDVV
NPAT
EAV
I
SRIPD
G
QAE
D
A
R
K
A
I
D
AA
ERA
Q
--PE
W
EALP
A
IE
R
ASW
L
R
K
IS
A
G
I
R
ERAS
E
I
S
A
L
I
VE
E
G
GK
-IQQLAEV
E
V
AFTADYID
Y
M
A
E
WARRYE
G
EIIQSD
---
--RPGENILLF
K
R
A
LGV
T
T
G
I
L
PWNFP
FF
L
IA
R
K
MA
PAL
LT
GN
T
I
V
I
KPSE
F
TP
TN
A
I
AF
A
K
I
VD
E
I
G
L
P
R
GV
F
N
L
V
L
G
R
G
ETV
G
QE
L
A
G
N
P
K
V
AM
VS
M
TGS
VS
A
G
E
K
I
MAT
A
-
A
K
NI
T
K
V
C
LELGGK
A
P
A
IV
MD
D
-
AD
-----
L
E
L
A
VKAIVDSRVI
N
S
GQVC
NCAE
R
I
YVQKGIY
D
Q
F
VNRLGEAMQAV
Q
F
G
NPAERN
D
IAM
GPL
I
N
A
A
A
L
E
R
V
EQK
V
AR
A
VEE
G
-
AR
V
AL
G
G
--
KAVE
G
--
-
-
K
GY
YYP
PTL
LLDVRQEMS
I
MH
EE
T
FGPVL
P
V
VAFDTL
EEAI
SM
ANDS
D
YGL
T
S
S
I
Y
T
Q
N
L
NV
A
M
K
A
I
KG
LK
F
G
ET
Y
I
N
RENFEAMQG
F
H
A
G
W
R
K
SG
I
G
GAD
G
KHG
L
HE
Y
LQT
Q
V
V
Y
L
fig|679206.4.peg.3042
Escherichia coli MS 119-7 (1-477/479)
M
S
VPV
Q
HP
M
Y
I
D
G
QFVTWRGD
---
AWIDVV
NPAT
EAV
I
SRIPD
G
QAE
D
A
R
K
A
I
D
AA
ERA
Q
--PE
W
EALP
A
IE
R
ASW
L
R
K
IS
A
G
I
R
ERAS
E
I
S
A
L
I
VE
E
G
GK
-IQQLAEV
E
V
AFTADYID
Y
M
A
E
WARRYE
G
EIIQSD
---
--RPGENILLF
K
R
A
LGV
T
T
G
I
L
PWNFP
FF
L
IA
R
K
MA
PAL
LT
GN
T
I
V
I
KPSE
F
TP
TN
A
I
AF
A
K
I
VD
E
I
G
L
P
R
GV
F
N
L
V
L
G
R
G
ETV
G
QE
L
A
G
N
P
K
V
AM
VS
M
TGS
VS
A
G
E
K
I
MAT
A
-
A
K
NI
T
K
V
C
LELGGK
A
P
A
IV
MD
D
-
AD
-----
L
E
L
A
VKAIVDSRVI
N
S
GQVC
NCAE
R
I
YVQKGIY
D
Q
F
VNRLGEAMQAV
Q
F
G
NPAERN
D
IAM
GPL
I
N
A
A
A
L
E
R
V
EQK
V
AR
A
VEE
G
-
AR
V
AL
G
G
--
KAVE
G
--
-
-
K
GY
YYP
PTL
LLDVRQEMS
I
MH
EE
T
FGPVL
P
V
VAFDTL
EEAI
SM
ANDS
D
YGL
T
S
S
I
Y
T
Q
N
L
NV
A
M
K
A
I
KG
LK
F
G
ET
Y
I
N
RENFEAMQG
F
H
A
G
W
R
K
SG
I
G
GAD
G
KHG
L
HE
Y
LQT
Q
V
V
Y
L
fig|656443.3.peg.1738
Escherichia coli TA271 (1-477/479)
M
S
VPV
Q
HP
M
Y
I
D
G
QFVTWRGD
---
AWIDVV
NPAT
EAV
I
SRIPD
G
QAE
D
A
R
K
A
I
D
AA
ERA
Q
--PE
W
EALP
A
IE
R
ASW
L
R
K
IS
A
G
I
R
ERAS
E
I
S
A
L
I
VE
E
G
GK
-IQQLAEV
E
V
AFTADYID
Y
M
A
E
WARRYE
G
EIIQSD
---
--RPGENILLF
K
R
A
LGV
T
T
G
I
L
PWNFP
FF
L
IA
R
K
MA
PAL
LT
GN
T
I
V
I
KPSE
F
TP
TN
A
I
AF
A
K
I
VD
E
I
G
L
P
R
GV
F
N
L
V
L
G
R
G
ETV
G
QE
L
A
G
N
P
K
V
AM
VS
M
TGS
VS
A
G
E
K
I
MAT
A
-
A
K
NI
T
K
V
C
LELGGK
A
P
A
IV
MD
D
-
AD
-----
L
E
L
A
VKAIVDSRVI
N
S
GQVC
NCAE
R
I
YVQKGIY
D
Q
F
VNRLGEAMQAV
Q
F
G
NPAERN
D
IAM
GPL
I
N
A
A
A
L
E
R
V
EQK
V
AR
A
VEE
G
-
AR
V
AL
G
G
--
KAVE
G
--
-
-
K
GY
YYP
PTL
LLDVRQEMS
I
MH
EE
T
FGPVL
P
V
VAFDTL
EEAI
SM
ANDS
D
YGL
T
S
S
I
Y
T
Q
N
L
NV
A
M
K
A
I
KG
LK
F
G
ET
Y
I
N
RENFEAMQG
F
H
A
G
W
R
K
SG
I
G
GAD
G
KHG
L
HE
Y
LQT
Q
V
V
Y
L
fig|344610.3.peg.1086
Escherichia coli 53638 (1-477/479)
M
S
VPV
Q
HP
M
Y
I
D
G
QFVTWRGD
---
AWIDVV
NPAT
EAV
I
SRIPD
G
QAE
D
A
R
K
A
I
D
AA
ERA
Q
--PE
W
EALP
A
IE
R
ASW
L
R
K
IS
A
G
I
R
ERAS
E
I
S
A
L
I
VE
E
G
GK
-IQQLAEV
E
V
AFTADYID
Y
M
A
E
WARRYE
G
EIIQSD
---
--RPRENILLF
K
R
A
LGV
T
T
G
I
L
PWNFP
FF
L
IA
R
K
MA
PAL
LT
GN
T
I
V
I
KPSE
F
TP
N
N
A
I
AF
A
K
I
VD
E
I
G
L
P
R
GV
F
N
L
V
L
G
R
G
ETV
G
QE
L
A
G
N
P
K
V
AM
VS
M
TGS
VS
A
G
E
K
I
MAT
A
-
A
K
NI
T
K
V
C
LELGGK
A
P
A
IV
MD
D
-
AD
-----
L
E
L
A
VKAIVDSRVI
N
S
GQVC
NCAE
R
I
YVQKGIY
D
Q
F
VNRLGEAMQAV
Q
F
G
NPAERN
D
IAM
GPL
I
N
A
A
A
L
E
R
V
EQK
V
AR
A
VEE
G
-
AR
V
AL
G
G
--
KAVE
G
--
-
-
K
GY
YYP
PTL
LLDVRQEMS
I
MH
EE
T
FGPVL
P
V
VAFDTL
EEAI
SM
ANDS
D
YGL
T
S
S
I
Y
T
Q
N
L
NV
A
M
K
A
I
KG
LK
F
G
ET
Y
I
N
RENFEAMQG
F
H
A
G
W
R
K
SG
I
G
GAD
G
KHG
L
HE
Y
LQT
Q
V
V
Y
L
fig|344610.7.peg.5075
Escherichia coli 53638 (1-477/479)
M
S
VPV
Q
HP
M
Y
I
D
G
QFVTWRGD
---
AWIDVV
NPAT
EAV
I
SRIPD
G
QAE
D
A
R
K
A
I
D
AA
ERA
Q
--PE
W
EALP
A
IE
R
ASW
L
R
K
IS
A
G
I
R
ERAS
E
I
S
A
L
I
VE
E
G
GK
-IQQLAEV
E
V
AFTADYID
Y
M
A
E
WARRYE
G
EIIQSD
---
--RPRENILLF
K
R
A
LGV
T
T
G
I
L
PWNFP
FF
L
IA
R
K
MA
PAL
LT
GN
T
I
V
I
KPSE
F
TP
N
N
A
I
AF
A
K
I
VD
E
I
G
L
P
R
GV
F
N
L
V
L
G
R
G
ETV
G
QE
L
A
G
N
P
K
V
AM
VS
M
TGS
VS
A
G
E
K
I
MAT
A
-
A
K
NI
T
K
V
C
LELGGK
A
P
A
IV
MD
D
-
AD
-----
L
E
L
A
VKAIVDSRVI
N
S
GQVC
NCAE
R
I
YVQKGIY
D
Q
F
VNRLGEAMQAV
Q
F
G
NPAERN
D
IAM
GPL
I
N
A
A
A
L
E
R
V
EQK
V
AR
A
VEE
G
-
AR
V
AL
G
G
--
KAVE
G
--
-
-
K
GY
YYP
PTL
LLDVRQEMS
I
MH
EE
T
FGPVL
P
V
VAFDTL
EEAI
SM
ANDS
D
YGL
T
S
S
I
Y
T
Q
N
L
NV
A
M
K
A
I
KG
LK
F
G
ET
Y
I
N
RENFEAMQG
F
H
A
G
W
R
K
SG
I
G
GAD
G
KHG
L
HE
Y
LQT
Q
V
V
Y
L
fig|431946.3.peg.1396
Escherichia coli SE15 (1-477/479)
M
S
VPV
Q
HP
M
Y
I
D
G
QFVTWRGD
---
AWIDVV
NPAT
EAV
I
SRIPD
G
QAE
D
A
R
K
A
I
D
AA
ERA
Q
--PE
W
EALP
A
IE
R
ASW
L
R
K
IS
A
G
I
R
ERAS
E
I
S
A
L
I
VE
E
G
GK
-IQQLAEV
E
V
AFTADYID
Y
M
A
E
WARRYE
G
EIIQSD
---
--RPGENILLF
K
R
A
LGV
T
T
G
I
L
PWNFP
FF
L
IA
R
K
MA
PAL
LT
GN
T
I
V
I
KPSE
F
TP
N
N
A
I
AF
A
K
I
VD
E
I
G
L
P
R
GV
F
N
L
V
L
G
R
G
ENV
G
QE
L
A
G
N
P
K
V
AM
VS
M
TGS
VS
A
G
E
K
I
MAT
A
-
A
K
NI
T
K
V
C
LELGGK
A
P
A
IV
MD
D
-
AD
-----
I
E
L
A
VKAIVDSRVI
N
S
GQVC
NCAE
RV
YVQKSIY
D
Q
F
VNRLGEAMQAV
Q
F
G
NPAERN
D
IAM
GPL
I
N
A
A
A
L
E
R
V
EQK
V
AR
A
VEE
G
-
AR
V
AL
G
G
--
KAVE
G
--
-
-
K
GY
YYP
PTL
LLDVRQEMS
I
MH
EE
T
FGPVL
P
V
VAFDTL
EEAI
SM
ANDS
D
YGL
T
S
S
I
Y
T
Q
N
L
NV
A
M
K
A
I
KG
LK
F
G
ET
Y
I
N
RENFEAMQG
F
H
A
G
W
R
K
SG
I
G
GAD
G
KHG
L
HE
Y
LQT
Q
V
V
Y
L
fig|525281.3.peg.53
Escherichia coli 83972 (1-477/479)
M
S
VPV
Q
HP
M
Y
I
D
G
QFVTWRGD
---
AWIDVV
NPAT
EAV
I
SRIPD
G
QAE
D
A
R
K
A
I
D
AA
ERA
Q
--PE
W
EALP
A
IE
R
ASW
L
R
K
IS
A
G
I
R
ERAT
E
I
S
A
L
I
VE
E
G
GK
-IQQLAEV
E
V
AFTADYID
Y
M
A
E
WARRYE
G
EIIQSD
---
--RPGENILLF
K
R
A
LGV
T
T
G
I
L
PWNFP
FF
L
IA
R
K
MD
PAL
LT
GN
T
I
V
I
KPSE
F
TP
N
N
A
I
AF
A
K
I
VD
E
I
G
L
P
R
GV
F
N
L
V
L
G
R
G
ETV
G
QE
L
A
G
N
P
K
V
AM
VS
M
TGS
VS
A
G
E
K
I
MAT
A
-
A
K
NI
T
K
V
C
LELGGK
A
P
A
IV
MD
D
-
AD
-----
L
E
L
A
VKAIVDSRVI
N
S
GQVC
NCAE
RV
YVQKSIY
D
Q
F
VNRLGEAMQAV
Q
F
G
NPAERN
D
IAM
GPL
I
N
A
A
A
L
E
R
V
EQK
V
AR
A
VEE
G
-
AR
V
AL
G
G
--
KAVE
G
--
-
-
K
GY
YYP
PTL
LLDVRQEMS
I
MH
EE
T
FGPVL
P
V
VAFDTL
EEAI
SM
ANDS
D
YGL
T
S
S
I
Y
T
Q
N
L
NV
A
M
K
A
I
KG
LK
F
G
ET
Y
I
N
RENFEAMQG
F
H
A
G
W
R
K
SG
I
G
GAD
G
KHG
L
HE
Y
LQT
Q
V
V
Y
L
fig|655817.3.peg.1728
Escherichia coli ABU 83972 (1-477/479)
M
S
VPV
Q
HP
M
Y
I
D
G
QFVTWRGD
---
AWIDVV
NPAT
EAV
I
SRIPD
G
QAE
D
A
R
K
A
I
D
AA
ERA
Q
--PE
W
EALP
A
IE
R
ASW
L
R
K
IS
A
G
I
R
ERAT
E
I
S
A
L
I
VE
E
G
GK
-IQQLAEV
E
V
AFTADYID
Y
M
A
E
WARRYE
G
EIIQSD
---
--RPGENILLF
K
R
A
LGV
T
T
G
I
L
PWNFP
FF
L
IA
R
K
MD
PAL
LT
GN
T
I
V
I
KPSE
F
TP
N
N
A
I
AF
A
K
I
VD
E
I
G
L
P
R
GV
F
N
L
V
L
G
R
G
ETV
G
QE
L
A
G
N
P
K
V
AM
VS
M
TGS
VS
A
G
E
K
I
MAT
A
-
A
K
NI
T
K
V
C
LELGGK
A
P
A
IV
MD
D
-
AD
-----
L
E
L
A
VKAIVDSRVI
N
S
GQVC
NCAE
RV
YVQKSIY
D
Q
F
VNRLGEAMQAV
Q
F
G
NPAERN
D
IAM
GPL
I
N
A
A
A
L
E
R
V
EQK
V
AR
A
VEE
G
-
AR
V
AL
G
G
--
KAVE
G
--
-
-
K
GY
YYP
PTL
LLDVRQEMS
I
MH
EE
T
FGPVL
P
V
VAFDTL
EEAI
SM
ANDS
D
YGL
T
S
S
I
Y
T
Q
N
L
NV
A
M
K
A
I
KG
LK
F
G
ET
Y
I
N
RENFEAMQG
F
H
A
G
W
R
K
SG
I
G
GAD
G
KHG
L
HE
Y
LQT
Q
V
V
Y
L
fig|656417.3.peg.1683
Escherichia coli M605 (1-477/479)
M
S
VPV
Q
HP
M
Y
I
D
G
QFVTWRGD
---
AWIDVV
NPAT
EAV
I
SRIPD
G
QAE
D
A
R
K
A
I
D
AA
ERA
Q
--PE
W
EALP
A
IE
R
ASW
L
R
K
IS
A
G
I
R
ERAS
E
I
S
A
L
I
VE
E
G
GK
-IQQLAEV
E
V
AFTADYID
Y
M
A
E
WARRYE
G
EIIQSD
---
--RPGENILLF
K
R
A
LGV
T
T
G
I
L
PWNFP
FF
L
IA
R
K
MA
PAL
LT
GN
T
I
V
I
KPSE
F
TP
N
N
A
I
AF
A
K
I
VD
E
I
G
L
P
R
GV
F
N
L
V
L
G
R
G
ETV
G
QE
L
A
G
N
P
K
V
AM
VS
M
TGS
VS
A
G
E
K
I
MAT
A
-
A
K
NI
T
K
V
C
LELGGK
A
P
A
IV
MD
D
-
AD
-----
I
E
L
A
VKAIVDSRVI
N
S
GQVC
NCAE
RV
YVQKSIY
D
Q
F
VNRLGEAMQAV
Q
F
G
NPAERN
D
IAM
GPL
I
N
A
A
A
L
E
R
V
EQK
V
AR
A
VEE
G
-
AR
V
AL
G
G
--
KAVE
G
--
-
-
K
GY
YYP
PTL
LLDVRQEMS
I
MH
EE
T
FGPVL
P
V
VAFDTL
EEAI
SM
ANDS
D
YGL
T
S
S
I
Y
T
Q
N
L
NV
A
M
K
A
I
KG
LK
F
G
ET
Y
I
N
RENFEAMQG
F
H
A
G
W
R
K
SG
I
G
GAD
G
KHG
L
HE
Y
LQT
Q
V
V
Y
L
fig|685038.3.peg.1410
Escherichia coli O83:H1 str. NRG 857C (1-477/479)
M
S
VPV
Q
HP
M
Y
I
D
G
QFVTWRGD
---
AWIDVV
NPAT
EAV
I
SRIPD
G
QAE
D
A
R
K
A
I
D
AA
ERA
Q
--PE
W
EALP
A
IE
R
ASW
L
R
K
IS
A
G
I
R
ERAS
E
I
S
A
L
I
VE
E
G
GK
-IQQLAEV
E
V
AFTADYID
Y
M
A
E
WARRYE
G
EIIQSD
---
--RPGENILLF
K
R
A
LGV
T
T
G
I
L
PWNFP
FF
L
IA
R
K
MA
PAL
LT
GN
T
I
V
I
KPSE
F
TP
N
N
A
I
AF
A
K
I
VD
E
I
G
L
P
R
GV
F
N
L
V
L
G
R
G
ETV
G
QE
L
A
G
N
P
K
V
AM
VS
M
TGS
VS
A
G
E
K
I
MAT
A
-
A
K
NI
T
K
V
C
LELGGK
A
P
A
IV
MD
D
-
AD
-----
I
E
L
A
VKAIVDSRVI
N
S
GQVC
NCAE
RV
YVQKSIY
D
Q
F
VNRLGEAMQAV
Q
F
G
NPAERN
D
IAM
GPL
I
N
A
A
A
L
E
R
V
EQK
V
AR
A
VEE
G
-
AR
V
AL
G
G
--
KAVE
G
--
-
-
K
GY
YYP
PTL
LLDVRQEMS
I
MH
EE
T
FGPVL
P
V
VAFDTL
EEAI
SM
ANDS
D
YGL
T
S
S
I
Y
T
Q
N
L
NV
A
M
K
A
I
KG
LK
F
G
ET
Y
I
N
RENFEAMQG
F
H
A
G
W
R
K
SG
I
G
GAD
G
KHG
L
HE
Y
LQT
Q
V
V
Y
L
fig|331111.12.peg.1881
Escherichia coli E24377A (1-477/479)
M
S
VPV
Q
HS
M
Y
I
D
G
QFVTWRGD
---
AWIDVV
NPAT
EAV
I
SRIPD
G
QAE
D
A
R
K
A
I
D
AA
ERA
Q
--PE
W
EALP
A
IE
R
ASW
L
R
K
IS
A
G
I
R
ERAS
E
I
S
A
L
I
VE
E
G
GK
-IQQLAEV
E
V
AFTADYID
Y
M
A
E
WARRYE
G
EIIQSD
---
--RPGENILLF
K
R
A
LGV
T
T
G
I
L
PWNFP
FF
L
IA
R
K
MA
PAL
LT
GN
T
I
V
I
KPSE
F
TP
N
N
A
I
AF
A
K
I
VD
E
I
G
L
P
R
GV
F
N
L
V
L
G
R
G
ETV
G
QE
L
A
G
N
P
K
V
AM
VS
M
TGS
VS
A
G
E
K
I
MAT
A
-
A
K
NI
T
K
V
C
LELGGK
A
P
A
IV
MD
D
-
AD
-----
L
E
L
A
VKAIVDSRVI
N
S
GQVC
NCAE
RV
YVQKGIY
D
Q
F
VNRLGEAMQAV
Q
F
G
NPAERN
D
IAM
GPL
I
N
A
A
A
L
E
R
V
EQK
V
AR
A
VEE
G
-
AR
V
AL
G
G
--
KAVE
G
--
-
-
K
GY
YYP
PTL
LLDVRQEMS
I
MH
EE
T
FGPVL
P
V
VAFDTL
EEAI
SM
ANDS
D
YGL
T
S
S
I
Y
T
Q
N
L
NV
A
M
K
A
I
KG
LK
F
G
ET
Y
I
N
RENFEAMQG
F
H
A
G
W
R
K
SG
I
G
GAD
G
KHG
L
HE
Y
LQT
Q
V
V
Y
L
fig|331111.3.peg.4041
Escherichia coli E24377A (1-477/479)
M
S
VPV
Q
HS
M
Y
I
D
G
QFVTWRGD
---
AWIDVV
NPAT
EAV
I
SRIPD
G
QAE
D
A
R
K
A
I
D
AA
ERA
Q
--PE
W
EALP
A
IE
R
ASW
L
R
K
IS
A
G
I
R
ERAS
E
I
S
A
L
I
VE
E
G
GK
-IQQLAEV
E
V
AFTADYID
Y
M
A
E
WARRYE
G
EIIQSD
---
--RPGENILLF
K
R
A
LGV
T
T
G
I
L
PWNFP
FF
L
IA
R
K
MA
PAL
LT
GN
T
I
V
I
KPSE
F
TP
N
N
A
I
AF
A
K
I
VD
E
I
G
L
P
R
GV
F
N
L
V
L
G
R
G
ETV
G
QE
L
A
G
N
P
K
V
AM
VS
M
TGS
VS
A
G
E
K
I
MAT
A
-
A
K
NI
T
K
V
C
LELGGK
A
P
A
IV
MD
D
-
AD
-----
L
E
L
A
VKAIVDSRVI
N
S
GQVC
NCAE
RV
YVQKGIY
D
Q
F
VNRLGEAMQAV
Q
F
G
NPAERN
D
IAM
GPL
I
N
A
A
A
L
E
R
V
EQK
V
AR
A
VEE
G
-
AR
V
AL
G
G
--
KAVE
G
--
-
-
K
GY
YYP
PTL
LLDVRQEMS
I
MH
EE
T
FGPVL
P
V
VAFDTL
EEAI
SM
ANDS
D
YGL
T
S
S
I
Y
T
Q
N
L
NV
A
M
K
A
I
KG
LK
F
G
ET
Y
I
N
RENFEAMQG
F
H
A
G
W
R
K
SG
I
G
GAD
G
KHG
L
HE
Y
LQT
Q
V
V
Y
L
fig|749527.3.peg.3781
Escherichia coli MS 21-1 (1-477/479)
M
S
VPV
Q
HP
M
Y
I
D
G
QFVTWRGD
---
AWIDVV
NPAT
EAV
I
SRIPD
G
QAE
D
V
R
K
A
I
D
AA
ERA
Q
--PE
W
EALP
A
IE
R
ASW
L
R
K
IS
A
G
I
R
ERAS
E
I
S
A
L
I
VE
E
G
GK
-IQQLAEV
E
V
AFTADYID
Y
M
S
E
WARRYE
G
EIIQSD
---
--RPGENILLF
K
R
A
LGV
T
T
G
I
L
PWNFP
FF
L
IA
R
K
MA
PAL
LT
GN
T
I
V
I
KPSE
F
TP
N
N
A
I
AF
A
K
I
VD
E
I
G
L
P
R
GV
F
N
L
V
L
G
R
G
ETV
G
QE
L
A
G
N
P
K
V
AM
VS
M
TGS
VS
A
G
E
K
I
MAT
A
-
A
K
NI
T
K
V
C
LELGGK
A
P
A
IV
MD
D
-
AD
-----
L
E
L
A
VKAIVDSRVI
N
S
GQVC
NCAE
RV
YVQKGIY
D
Q
F
VNRLGEAMQAV
Q
F
G
NPAERN
D
IAM
GPL
I
N
A
A
A
L
E
R
V
EQK
V
AR
A
VEE
G
-
AR
V
AL
G
G
--
KAVE
G
--
-
-
K
GY
YYP
PTL
LLDVRQEMS
I
MH
EE
T
FGPVL
P
V
VAFDTL
EEAI
SM
ANDS
D
YGL
T
S
S
I
Y
T
Q
N
L
NV
A
M
K
A
I
KG
LK
F
G
ET
Y
I
N
RENFEAMQG
F
H
A
G
W
R
K
SG
I
G
GAD
G
KHG
L
HE
Y
LQT
Q
V
V
Y
L
fig|439855.10.peg.1912
Escherichia coli SMS-3-5 (1-477/479)
M
S
VPV
Q
HP
M
Y
I
D
G
QFVTWRGD
---
AWIDVV
NPAT
EAV
I
SRIPD
G
QAE
D
V
R
K
A
I
D
AA
ERA
Q
--PE
W
EALP
A
IE
R
ASW
L
R
K
IS
A
G
I
R
KRAS
E
I
S
A
L
I
VE
E
G
GK
-IQQLAEV
E
V
AFTADYID
Y
M
A
E
WARRYE
G
EIIQSD
---
--RPGENILLF
K
R
A
LGV
T
T
G
I
L
PWNFP
FF
L
IA
R
K
MA
PAL
LT
GN
T
I
V
I
KPSE
F
TP
N
N
A
I
AF
A
K
I
VD
E
I
G
L
P
R
GV
F
N
L
V
L
G
R
G
ETV
G
QE
L
A
G
N
P
K
V
AM
VS
M
TGS
VS
A
G
E
K
I
MAT
A
-
A
K
NI
T
K
V
C
LELGGK
A
P
A
IV
MD
D
-
AD
-----
L
E
L
A
VKAIVDSRVI
N
S
GQVC
NCAE
RV
YVQKGIY
D
Q
F
VNRLGEALQAV
Q
F
G
NPAERN
D
IAM
GPL
I
N
A
A
A
L
E
R
V
EQK
V
AR
A
VEE
G
-
AR
V
AL
G
G
--
KAVE
G
--
-
-
K
GY
YYP
PTL
LLDVRQEMS
I
MH
EE
T
FGPVL
P
V
VAFDTL
EEAI
SM
ANDS
D
YGL
T
S
S
I
Y
T
Q
N
L
NV
A
M
K
A
I
NG
LK
F
G
ET
Y
I
N
RENFEAMQG
F
H
A
G
W
R
K
SG
I
G
GAD
G
KHG
L
HE
Y
LQT
Q
V
V
Y
L
fig|656393.3.peg.2148
Escherichia coli H299 (1-477/479)
M
S
VPV
Q
HP
M
Y
I
D
G
QFVTWRGD
---
AWIDVV
NPAT
EAV
I
SRIPD
G
QAE
D
A
R
K
A
I
D
AA
ERA
Q
--PE
W
EALP
A
IE
R
ASW
L
R
K
IS
A
G
I
R
ERAS
E
I
S
T
L
I
VE
E
G
GK
-IQQLAEV
E
V
AFTADYID
Y
M
A
E
WARRYE
G
EIIQSD
---
--RPGENILLF
K
R
A
LGV
T
T
G
I
L
PWNFP
FF
L
IA
R
K
MA
PAL
LT
GN
T
I
V
I
KPSE
F
TP
N
N
A
I
AF
A
K
I
VD
E
I
G
L
P
R
GV
F
N
L
V
L
G
R
G
ETV
G
QE
L
A
G
N
P
K
V
AM
VS
M
TGS
VS
A
G
E
K
I
MAT
A
-
A
K
NI
T
K
V
C
LELGGK
A
P
A
IV
MD
D
-
AD
-----
L
E
L
A
VKAIVDSRVI
N
S
GQVC
NCAE
RV
YVQKGIY
D
Q
F
VNRLGEAMQAV
Q
F
G
NPAERN
D
IAM
GPL
I
N
A
A
A
L
E
R
V
EQK
V
AR
A
VEE
G
-
AR
V
AL
G
G
--
KAVE
G
--
-
-
K
GY
YYP
PTL
LLDVRQEMS
I
MH
EE
T
FGPVL
P
V
VAFDTL
EEAI
SM
ANDS
D
YGL
T
S
S
I
Y
T
Q
N
L
NV
A
M
K
A
I
KG
LK
F
G
ET
Y
I
N
RENFEAMQG
F
H
A
G
W
R
K
SG
I
G
GAD
G
KHG
L
HE
Y
LQT
Q
V
V
Y
L
fig|362663.8.peg.1432
Escherichia coli 536 (1-477/479)
M
S
VPV
Q
HP
M
Y
I
D
G
QFVTWRGD
---
AWIDVV
NPAT
EVV
I
SRIPD
G
QAE
D
A
R
K
A
I
D
AA
ERA
Q
--PE
W
EALP
A
IE
R
ASW
L
R
K
IS
A
G
I
R
ERAS
E
I
S
A
L
I
VE
E
G
GK
-IQQLAEV
E
V
AFTADYID
Y
M
A
E
WARRYE
G
EIIQSD
---
--RPGENILLF
K
R
A
LGV
T
T
G
I
L
PWNFP
FF
L
IA
R
K
MA
PAL
LT
GN
T
I
V
I
KPSE
F
TP
N
N
A
I
AF
A
K
I
VD
E
I
G
L
P
R
GV
F
N
L
V
L
G
R
G
ETV
G
QE
L
A
G
N
P
K
V
AM
VS
M
TGS
VS
A
G
E
K
I
MAT
A
-
A
K
NI
T
K
V
C
LELGGK
A
P
A
IV
MD
D
-
AD
-----
L
E
L
A
VKAIVDSRVI
N
S
GQVC
NCAE
RV
YVQKSIY
D
Q
F
VNRLGEAMQAV
Q
F
G
NPAERN
D
IAM
GPL
I
N
A
A
A
L
E
R
V
EQK
V
AR
A
VEE
G
-
AR
V
AL
G
G
--
KAVE
G
--
-
-
K
GY
YYP
PTL
LLDVRQEMS
I
MH
EE
T
FGPVL
P
V
VAFDTL
EEAI
SM
ANDS
D
YGL
T
S
S
I
Y
T
Q
N
L
NV
A
M
K
A
I
KG
LK
F
G
ET
Y
I
N
RENFEAMQG
F
H
A
G
W
R
K
SG
I
G
GAD
G
KHG
L
HE
Y
LQT
Q
V
V
Y
L
fig|362663.9.peg.1435
Escherichia coli 536 (1-477/479)
M
S
VPV
Q
HP
M
Y
I
D
G
QFVTWRGD
---
AWIDVV
NPAT
EVV
I
SRIPD
G
QAE
D
A
R
K
A
I
D
AA
ERA
Q
--PE
W
EALP
A
IE
R
ASW
L
R
K
IS
A
G
I
R
ERAS
E
I
S
A
L
I
VE
E
G
GK
-IQQLAEV
E
V
AFTADYID
Y
M
A
E
WARRYE
G
EIIQSD
---
--RPGENILLF
K
R
A
LGV
T
T
G
I
L
PWNFP
FF
L
IA
R
K
MA
PAL
LT
GN
T
I
V
I
KPSE
F
TP
N
N
A
I
AF
A
K
I
VD
E
I
G
L
P
R
GV
F
N
L
V
L
G
R
G
ETV
G
QE
L
A
G
N
P
K
V
AM
VS
M
TGS
VS
A
G
E
K
I
MAT
A
-
A
K
NI
T
K
V
C
LELGGK
A
P
A
IV
MD
D
-
AD
-----
L
E
L
A
VKAIVDSRVI
N
S
GQVC
NCAE
RV
YVQKSIY
D
Q
F
VNRLGEAMQAV
Q
F
G
NPAERN
D
IAM
GPL
I
N
A
A
A
L
E
R
V
EQK
V
AR
A
VEE
G
-
AR
V
AL
G
G
--
KAVE
G
--
-
-
K
GY
YYP
PTL
LLDVRQEMS
I
MH
EE
T
FGPVL
P
V
VAFDTL
EEAI
SM
ANDS
D
YGL
T
S
S
I
Y
T
Q
N
L
NV
A
M
K
A
I
KG
LK
F
G
ET
Y
I
N
RENFEAMQG
F
H
A
G
W
R
K
SG
I
G
GAD
G
KHG
L
HE
Y
LQT
Q
V
V
Y
L
fig|405955.13.peg.1543
Escherichia coli APEC O1 (1-477/479)
M
S
VPV
Q
HP
M
Y
I
D
G
QFVTWRGD
---
AWIDVV
NPAT
EVV
I
SRIPD
G
QAE
D
A
R
K
A
I
D
AA
ERA
Q
--PE
W
EALP
A
IE
R
ASW
L
R
K
IS
A
G
I
R
ERAS
E
I
S
A
L
I
VE
E
G
GK
-IQQLAEV
E
V
AFTADYID
Y
M
A
E
WARRYE
G
EIIQSD
---
--RPGENILLF
K
R
A
LGV
T
T
G
I
L
PWNFP
FF
L
IA
R
K
MA
PAL
LT
GN
T
I
V
I
KPSE
F
TP
N
N
A
I
AF
A
K
I
VD
E
I
G
L
P
R
GV
F
N
L
V
L
G
R
G
ETV
G
QE
L
A
G
N
P
K
V
AM
VS
M
TGS
VS
A
G
E
K
I
MAT
A
-
A
K
NI
T
K
V
C
LELGGK
A
P
A
IV
MD
D
-
AD
-----
L
E
L
A
VKAIVDSRVI
N
S
GQVC
NCAE
RV
YVQKSIY
D
Q
F
VNRLGEAMQAV
Q
F
G
NPAERN
D
IAM
GPL
I
N
A
A
A
L
E
R
V
EQK
V
AR
A
VEE
G
-
AR
V
AL
G
G
--
KAVE
G
--
-
-
K
GY
YYP
PTL
LLDVRQEMS
I
MH
EE
T
FGPVL
P
V
VAFDTL
EEAI
SM
ANDS
D
YGL
T
S
S
I
Y
T
Q
N
L
NV
A
M
K
A
I
KG
LK
F
G
ET
Y
I
N
RENFEAMQG
F
H
A
G
W
R
K
SG
I
G
GAD
G
KHG
L
HE
Y
LQT
Q
V
V
Y
L
fig|405955.9.peg.1262
Escherichia coli APEC O1 (1-477/479)
M
S
VPV
Q
HP
M
Y
I
D
G
QFVTWRGD
---
AWIDVV
NPAT
EVV
I
SRIPD
G
QAE
D
A
R
K
A
I
D
AA
ERA
Q
--PE
W
EALP
A
IE
R
ASW
L
R
K
IS
A
G
I
R
ERAS
E
I
S
A
L
I
VE
E
G
GK
-IQQLAEV
E
V
AFTADYID
Y
M
A
E
WARRYE
G
EIIQSD
---
--RPGENILLF
K
R
A
LGV
T
T
G
I
L
PWNFP
FF
L
IA
R
K
MA
PAL
LT
GN
T
I
V
I
KPSE
F
TP
N
N
A
I
AF
A
K
I
VD
E
I
G
L
P
R
GV
F
N
L
V
L
G
R
G
ETV
G
QE
L
A
G
N
P
K
V
AM
VS
M
TGS
VS
A
G
E
K
I
MAT
A
-
A
K
NI
T
K
V
C
LELGGK
A
P
A
IV
MD
D
-
AD
-----
L
E
L
A
VKAIVDSRVI
N
S
GQVC
NCAE
RV
YVQKSIY
D
Q
F
VNRLGEAMQAV
Q
F
G
NPAERN
D
IAM
GPL
I
N
A
A
A
L
E
R
V
EQK
V
AR
A
VEE
G
-
AR
V
AL
G
G
--
KAVE
G
--
-
-
K
GY
YYP
PTL
LLDVRQEMS
I
MH
EE
T
FGPVL
P
V
VAFDTL
EEAI
SM
ANDS
D
YGL
T
S
S
I
Y
T
Q
N
L
NV
A
M
K
A
I
KG
LK
F
G
ET
Y
I
N
RENFEAMQG
F
H
A
G
W
R
K
SG
I
G
GAD
G
KHG
L
HE
Y
LQT
Q
V
V
Y
L
fig|340197.3.peg.1196
Escherichia coli F11 (1-477/479)
M
S
VPV
Q
HP
M
Y
I
D
G
QFVTWRGD
---
AWIDVV
NPAT
EVV
I
SRIPD
G
QAE
D
A
R
K
A
I
D
AA
ERA
Q
--PE
W
EALP
A
IE
R
ASW
L
R
K
IS
A
G
I
R
ERAS
E
I
S
A
L
I
VE
E
G
GK
-IQQLAEV
E
V
AFTADYID
Y
M
A
E
WARRYE
G
EIIQSD
---
--RPGENILLF
K
R
A
LGV
T
T
G
I
L
PWNFP
FF
L
IA
R
K
MA
PAL
LT
GN
T
I
V
I
KPSE
F
TP
N
N
A
I
AF
A
K
I
VD
E
I
G
L
P
R
GV
F
N
L
V
L
G
R
G
ETV
G
QE
L
A
G
N
P
K
V
AM
VS
M
TGS
VS
A
G
E
K
I
MAT
A
-
A
K
NI
T
K
V
C
LELGGK
A
P
A
IV
MD
D
-
AD
-----
L
E
L
A
VKAIVDSRVI
N
S
GQVC
NCAE
RV
YVQKSIY
D
Q
F
VNRLGEAMQAV
Q
F
G
NPAERN
D
IAM
GPL
I
N
A
A
A
L
E
R
V
EQK
V
AR
A
VEE
G
-
AR
V
AL
G
G
--
KAVE
G
--
-
-
K
GY
YYP
PTL
LLDVRQEMS
I
MH
EE
T
FGPVL
P
V
VAFDTL
EEAI
SM
ANDS
D
YGL
T
S
S
I
Y
T
Q
N
L
NV
A
M
K
A
I
KG
LK
F
G
ET
Y
I
N
RENFEAMQG
F
H
A
G
W
R
K
SG
I
G
GAD
G
KHG
L
HE
Y
LQT
Q
V
V
Y
L
fig|340197.5.peg.1260
Escherichia coli F11 (1-477/479)
M
S
VPV
Q
HP
M
Y
I
D
G
QFVTWRGD
---
AWIDVV
NPAT
EVV
I
SRIPD
G
QAE
D
A
R
K
A
I
D
AA
ERA
Q
--PE
W
EALP
A
IE
R
ASW
L
R
K
IS
A
G
I
R
ERAS
E
I
S
A
L
I
VE
E
G
GK
-IQQLAEV
E
V
AFTADYID
Y
M
A
E
WARRYE
G
EIIQSD
---
--RPGENILLF
K
R
A
LGV
T
T
G
I
L
PWNFP
FF
L
IA
R
K
MA
PAL
LT
GN
T
I
V
I
KPSE
F
TP
N
N
A
I
AF
A
K
I
VD
E
I
G
L
P
R
GV
F
N
L
V
L
G
R
G
ETV
G
QE
L
A
G
N
P
K
V
AM
VS
M
TGS
VS
A
G
E
K
I
MAT
A
-
A
K
NI
T
K
V
C
LELGGK
A
P
A
IV
MD
D
-
AD
-----
L
E
L
A
VKAIVDSRVI
N
S
GQVC
NCAE
RV
YVQKSIY
D
Q
F
VNRLGEAMQAV
Q
F
G
NPAERN
D
IAM
GPL
I
N
A
A
A
L
E
R
V
EQK
V
AR
A
VEE
G
-
AR
V
AL
G
G
--
KAVE
G
--
-
-
K
GY
YYP
PTL
LLDVRQEMS
I
MH
EE
T
FGPVL
P
V
VAFDTL
EEAI
SM
ANDS
D
YGL
T
S
S
I
Y
T
Q
N
L
NV
A
M
K
A
I
KG
LK
F
G
ET
Y
I
N
RENFEAMQG
F
H
A
G
W
R
K
SG
I
G
GAD
G
KHG
L
HE
Y
LQT
Q
V
V
Y
L
fig|714962.3.peg.1610
Escherichia coli IHE3034 (1-477/479)
M
S
VPV
Q
HP
M
Y
I
D
G
QFVTWRGD
---
AWIDVV
NPAT
EVV
I
SRIPD
G
QAE
D
A
R
K
A
I
D
AA
ERA
Q
--PE
W
EALP
A
IE
R
ASW
L
R
K
IS
A
G
I
R
ERAS
E
I
S
A
L
I
VE
E
G
GK
-IQQLAEV
E
V
AFTADYID
Y
M
A
E
WARRYE
G
EIIQSD
---
--RPGENILLF
K
R
A
LGV
T
T
G
I
L
PWNFP
FF
L
IA
R
K
MA
PAL
LT
GN
T
I
V
I
KPSE
F
TP
N
N
A
I
AF
A
K
I
VD
E
I
G
L
P
R
GV
F
N
L
V
L
G
R
G
ETV
G
QE
L
A
G
N
P
K
V
AM
VS
M
TGS
VS
A
G
E
K
I
MAT
A
-
A
K
NI
T
K
V
C
LELGGK
A
P
A
IV
MD
D
-
AD
-----
L
E
L
A
VKAIVDSRVI
N
S
GQVC
NCAE
RV
YVQKSIY
D
Q
F
VNRLGEAMQAV
Q
F
G
NPAERN
D
IAM
GPL
I
N
A
A
A
L
E
R
V
EQK
V
AR
A
VEE
G
-
AR
V
AL
G
G
--
KAVE
G
--
-
-
K
GY
YYP
PTL
LLDVRQEMS
I
MH
EE
T
FGPVL
P
V
VAFDTL
EEAI
SM
ANDS
D
YGL
T
S
S
I
Y
T
Q
N
L
NV
A
M
K
A
I
KG
LK
F
G
ET
Y
I
N
RENFEAMQG
F
H
A
G
W
R
K
SG
I
G
GAD
G
KHG
L
HE
Y
LQT
Q
V
V
Y
L
fig|749550.3.peg.204
Escherichia coli MS 200-1 (1-477/479)
M
S
VPV
Q
HP
M
Y
I
D
G
QFVTWRGD
---
AWIDVV
NPAT
EVV
I
SRIPD
G
QAE
D
A
R
K
A
I
D
AA
ERA
Q
--PE
W
EALP
A
IE
R
ASW
L
R
K
IS
A
G
I
R
ERAS
E
I
S
A
L
I
VE
E
G
GK
-IQQLAEV
E
V
AFTADYID
Y
M
A
E
WARRYE
G
EIIQSD
---
--RPGENILLF
K
R
A
LGV
T
T
G
I
L
PWNFP
FF
L
IA
R
K
MA
PAL
LT
GN
T
I
V
I
KPSE
F
TP
N
N
A
I
AF
A
K
I
VD
E
I
G
L
P
R
GV
F
N
L
V
L
G
R
G
ETV
G
QE
L
A
G
N
P
K
V
AM
VS
M
TGS
VS
A
G
E
K
I
MAT
A
-
A
K
NI
T
K
V
C
LELGGK
A
P
A
IV
MD
D
-
AD
-----
L
E
L
A
VKAIVDSRVI
N
S
GQVC
NCAE
RV
YVQKSIY
D
Q
F
VNRLGEAMQAV
Q
F
G
NPAERN
D
IAM
GPL
I
N
A
A
A
L
E
R
V
EQK
V
AR
A
VEE
G
-
AR
V
AL
G
G
--
KAVE
G
--
-
-
K
GY
YYP
PTL
LLDVRQEMS
I
MH
EE
T
FGPVL
P
V
VAFDTL
EEAI
SM
ANDS
D
YGL
T
S
S
I
Y
T
Q
N
L
NV
A
M
K
A
I
KG
LK
F
G
ET
Y
I
N
RENFEAMQG
F
H
A
G
W
R
K
SG
I
G
GAD
G
KHG
L
HE
Y
LQT
Q
V
V
Y
L
fig|585035.6.peg.1501
Escherichia coli S88 (1-477/479)
M
S
VPV
Q
HP
M
Y
I
D
G
QFVTWRGD
---
AWIDVV
NPAT
EVV
I
SRIPD
G
QAE
D
A
R
K
A
I
D
AA
ERA
Q
--PE
W
EALP
A
IE
R
ASW
L
R
K
IS
A
G
I
R
ERAS
E
I
S
A
L
I
VE
E
G
GK
-IQQLAEV
E
V
AFTADYID
Y
M
A
E
WARRYE
G
EIIQSD
---
--RPGENILLF
K
R
A
LGV
T
T
G
I
L
PWNFP
FF
L
IA
R
K
MA
PAL
LT
GN
T
I
V
I
KPSE
F
TP
N
N
A
I
AF
A
K
I
VD
E
I
G
L
P
R
GV
F
N
L
V
L
G
R
G
ETV
G
QE
L
A
G
N
P
K
V
AM
VS
M
TGS
VS
A
G
E
K
I
MAT
A
-
A
K
NI
T
K
V
C
LELGGK
A
P
A
IV
MD
D
-
AD
-----
L
E
L
A
VKAIVDSRVI
N
S
GQVC
NCAE
RV
YVQKSIY
D
Q
F
VNRLGEAMQAV
Q
F
G
NPAERN
D
IAM
GPL
I
N
A
A
A
L
E
R
V
EQK
V
AR
A
VEE
G
-
AR
V
AL
G
G
--
KAVE
G
--
-
-
K
GY
YYP
PTL
LLDVRQEMS
I
MH
EE
T
FGPVL
P
V
VAFDTL
EEAI
SM
ANDS
D
YGL
T
S
S
I
Y
T
Q
N
L
NV
A
M
K
A
I
KG
LK
F
G
ET
Y
I
N
RENFEAMQG
F
H
A
G
W
R
K
SG
I
G
GAD
G
KHG
L
HE
Y
LQT
Q
V
V
Y
L
fig|869729.3.peg.2110
Escherichia coli UM146 (1-477/479)
M
S
VPV
Q
HP
M
Y
I
D
G
QFVTWRGD
---
AWIDVV
NPAT
EVV
I
SRIPD
G
QAE
D
A
R
K
A
I
D
AA
ERA
Q
--PE
W
EALP
A
IE
R
ASW
L
R
K
IS
A
G
I
R
ERAS
E
I
S
A
L
I
VE
E
G
GK
-IQQLAEV
E
V
AFTADYID
Y
M
A
E
WARRYE
G
EIIQSD
---
--RPGENILLF
K
R
A
LGV
T
T
G
I
L
PWNFP
FF
L
IA
R
K
MA
PAL
LT
GN
T
I
V
I
KPSE
F
TP
N
N
A
I
AF
A
K
I
VD
E
I
G
L
P
R
GV
F
N
L
V
L
G
R
G
ETV
G
QE
L
A
G
N
P
K
V
AM
VS
M
TGS
VS
A
G
E
K
I
MAT
A
-
A
K
NI
T
K
V
C
LELGGK
A
P
A
IV
MD
D
-
AD
-----
L
E
L
A
VKAIVDSRVI
N
S
GQVC
NCAE
RV
YVQKSIY
D
Q
F
VNRLGEAMQAV
Q
F
G
NPAERN
D
IAM
GPL
I
N
A
A
A
L
E
R
V
EQK
V
AR
A
VEE
G
-
AR
V
AL
G
G
--
KAVE
G
--
-
-
K
GY
YYP
PTL
LLDVRQEMS
I
MH
EE
T
FGPVL
P
V
VAFDTL
EEAI
SM
ANDS
D
YGL
T
S
S
I
Y
T
Q
N
L
NV
A
M
K
A
I
KG
LK
F
G
ET
Y
I
N
RENFEAMQG
F
H
A
G
W
R
K
SG
I
G
GAD
G
KHG
L
HE
Y
LQT
Q
V
V
Y
L
fig|364106.7.peg.1680
Escherichia coli UTI89 (1-477/479)
M
S
VPV
Q
HP
M
Y
I
D
G
QFVTWRGD
---
AWIDVV
NPAT
EVV
I
SRIPD
G
QAE
D
A
R
K
A
I
D
AA
ERA
Q
--PE
W
EALP
A
IE
R
ASW
L
R
K
IS
A
G
I
R
ERAS
E
I
S
A
L
I
VE
E
G
GK
-IQQLAEV
E
V
AFTADYID
Y
M
A
E
WARRYE
G
EIIQSD
---
--RPGENILLF
K
R
A
LGV
T
T
G
I
L
PWNFP
FF
L
IA
R
K
MA
PAL
LT
GN
T
I
V
I
KPSE
F
TP
N
N
A
I
AF
A
K
I
VD
E
I
G
L
P
R
GV
F
N
L
V
L
G
R
G
ETV
G
QE
L
A
G
N
P
K
V
AM
VS
M
TGS
VS
A
G
E
K
I
MAT
A
-
A
K
NI
T
K
V
C
LELGGK
A
P
A
IV
MD
D
-
AD
-----
L
E
L
A
VKAIVDSRVI
N
S
GQVC
NCAE
RV
YVQKSIY
D
Q
F
VNRLGEAMQAV
Q
F
G
NPAERN
D
IAM
GPL
I
N
A
A
A
L
E
R
V
EQK
V
AR
A
VEE
G
-
AR
V
AL
G
G
--
KAVE
G
--
-
-
K
GY
YYP
PTL
LLDVRQEMS
I
MH
EE
T
FGPVL
P
V
VAFDTL
EEAI
SM
ANDS
D
YGL
T
S
S
I
Y
T
Q
N
L
NV
A
M
K
A
I
KG
LK
F
G
ET
Y
I
N
RENFEAMQG
F
H
A
G
W
R
K
SG
I
G
GAD
G
KHG
L
HE
Y
LQT
Q
V
V
Y
L
fig|364106.8.peg.1681
Escherichia coli UTI89 (1-477/479)
M
S
VPV
Q
HP
M
Y
I
D
G
QFVTWRGD
---
AWIDVV
NPAT
EVV
I
SRIPD
G
QAE
D
A
R
K
A
I
D
AA
ERA
Q
--PE
W
EALP
A
IE
R
ASW
L
R
K
IS
A
G
I
R
ERAS
E
I
S
A
L
I
VE
E
G
GK
-IQQLAEV
E
V
AFTADYID
Y
M
A
E
WARRYE
G
EIIQSD
---
--RPGENILLF
K
R
A
LGV
T
T
G
I
L
PWNFP
FF
L
IA
R
K
MA
PAL
LT
GN
T
I
V
I
KPSE
F
TP
N
N
A
I
AF
A
K
I
VD
E
I
G
L
P
R
GV
F
N
L
V
L
G
R
G
ETV
G
QE
L
A
G
N
P
K
V
AM
VS
M
TGS
VS
A
G
E
K
I
MAT
A
-
A
K
NI
T
K
V
C
LELGGK
A
P
A
IV
MD
D
-
AD
-----
L
E
L
A
VKAIVDSRVI
N
S
GQVC
NCAE
RV
YVQKSIY
D
Q
F
VNRLGEAMQAV
Q
F
G
NPAERN
D
IAM
GPL
I
N
A
A
A
L
E
R
V
EQK
V
AR
A
VEE
G
-
AR
V
AL
G
G
--
KAVE
G
--
-
-
K
GY
YYP
PTL
LLDVRQEMS
I
MH
EE
T
FGPVL
P
V
VAFDTL
EEAI
SM
ANDS
D
YGL
T
S
S
I
Y
T
Q
N
L
NV
A
M
K
A
I
KG
LK
F
G
ET
Y
I
N
RENFEAMQG
F
H
A
G
W
R
K
SG
I
G
GAD
G
KHG
L
HE
Y
LQT
Q
V
V
Y
L
fig|550677.3.peg.2829
Escherichia coli B354 (1-477/479)
M
S
VPV
Q
HP
M
Y
I
D
G
QFVTWRGD
---
AWIDVV
NPAT
EAV
I
SRIPD
G
QAE
D
A
R
K
A
I
D
AA
ERA
Q
--PE
W
EALP
A
IE
R
ASW
L
R
K
IS
A
G
I
R
ERAS
E
I
S
A
L
I
VE
E
G
GK
-IQQLAEV
E
V
AFTADYID
Y
M
A
E
WARRYE
G
EIIQSD
---
--RPGENILLF
K
R
A
LGV
T
T
G
I
L
PWNFP
FF
L
IA
R
K
MA
PAL
LT
GN
T
I
V
I
KPSE
F
TP
N
N
A
I
AF
A
K
I
VD
E
I
G
L
P
R
GV
F
N
L
V
L
G
R
G
ETV
G
QE
L
A
G
N
P
K
V
AM
VS
M
TGS
VS
A
G
E
K
I
MAT
A
-
A
K
NI
T
K
V
C
LELGGK
A
P
A
IV
MD
D
-
AD
-----
L
E
L
A
VKAIVDSRVI
N
S
GQVC
NCAE
RV
YVQKGIY
D
Q
F
VNRLGEAMQAV
Q
F
G
NPAERN
D
IAM
GPL
I
N
A
A
A
L
E
R
V
EQK
V
AR
A
VEE
G
-
AR
V
AL
G
G
--
KAVE
G
--
-
-
K
GY
YYP
PTL
LLDVRQEMS
I
MH
EE
T
FGPVL
P
V
VAFDTL
EEAI
SM
ANDS
D
YGL
T
S
S
I
Y
T
Q
N
L
NV
A
M
K
A
I
KG
LK
F
G
ET
Y
I
N
RENFEAMQG
F
H
A
G
W
R
K
SG
I
G
GAD
G
KHG
L
HE
Y
LQT
Q
V
V
Y
L
fig|340184.3.peg.150
Escherichia coli B7A (1-477/479)
M
S
VPV
Q
HP
M
Y
I
D
G
QFVTWRGD
---
AWIDVV
NPAT
EAV
I
SRIPD
G
QAE
D
A
R
K
A
I
D
AA
ERA
Q
--PE
W
EALP
A
IE
R
ASW
L
R
K
IS
A
G
I
R
ERAS
E
I
S
A
L
I
VE
E
G
GK
-IQQLAEV
E
V
AFTADYID
Y
M
A
E
WARRYE
G
EIIQSD
---
--RPGENILLF
K
R
A
LGV
T
T
G
I
L
PWNFP
FF
L
IA
R
K
MA
PAL
LT
GN
T
I
V
I
KPSE
F
TP
N
N
A
I
AF
A
K
I
VD
E
I
G
L
P
R
GV
F
N
L
V
L
G
R
G
ETV
G
QE
L
A
G
N
P
K
V
AM
VS
M
TGS
VS
A
G
E
K
I
MAT
A
-
A
K
NI
T
K
V
C
LELGGK
A
P
A
IV
MD
D
-
AD
-----
L
E
L
A
VKAIVDSRVI
N
S
GQVC
NCAE
RV
YVQKGIY
D
Q
F
VNRLGEAMQAV
Q
F
G
NPAERN
D
IAM
GPL
I
N
A
A
A
L
E
R
V
EQK
V
AR
A
VEE
G
-
AR
V
AL
G
G
--
KAVE
G
--
-
-
K
GY
YYP
PTL
LLDVRQEMS
I
MH
EE
T
FGPVL
P
V
VAFDTL
EEAI
SM
ANDS
D
YGL
T
S
S
I
Y
T
Q
N
L
NV
A
M
K
A
I
KG
LK
F
G
ET
Y
I
N
RENFEAMQG
F
H
A
G
W
R
K
SG
I
G
GAD
G
KHG
L
HE
Y
LQT
Q
V
V
Y
L
fig|340184.6.peg.155
Escherichia coli B7A (1-477/479)
M
S
VPV
Q
HP
M
Y
I
D
G
QFVTWRGD
---
AWIDVV
NPAT
EAV
I
SRIPD
G
QAE
D
A
R
K
A
I
D
AA
ERA
Q
--PE
W
EALP
A
IE
R
ASW
L
R
K
IS
A
G
I
R
ERAS
E
I
S
A
L
I
VE
E
G
GK
-IQQLAEV
E
V
AFTADYID
Y
M
A
E
WARRYE
G
EIIQSD
---
--RPGENILLF
K
R
A
LGV
T
T
G
I
L
PWNFP
FF
L
IA
R
K
MA
PAL
LT
GN
T
I
V
I
KPSE
F
TP
N
N
A
I
AF
A
K
I
VD
E
I
G
L
P
R
GV
F
N
L
V
L
G
R
G
ETV
G
QE
L
A
G
N
P
K
V
AM
VS
M
TGS
VS
A
G
E
K
I
MAT
A
-
A
K
NI
T
K
V
C
LELGGK
A
P
A
IV
MD
D
-
AD
-----
L
E
L
A
VKAIVDSRVI
N
S
GQVC
NCAE
RV
YVQKGIY
D
Q
F
VNRLGEAMQAV
Q
F
G
NPAERN
D
IAM
GPL
I
N
A
A
A
L
E
R
V
EQK
V
AR
A
VEE
G
-
AR
V
AL
G
G
--
KAVE
G
--
-
-
K
GY
YYP
PTL
LLDVRQEMS
I
MH
EE
T
FGPVL
P
V
VAFDTL
EEAI
SM
ANDS
D
YGL
T
S
S
I
Y
T
Q
N
L
NV
A
M
K
A
I
KG
LK
F
G
ET
Y
I
N
RENFEAMQG
F
H
A
G
W
R
K
SG
I
G
GAD
G
KHG
L
HE
Y
LQT
Q
V
V
Y
L
fig|340185.3.peg.1048
Escherichia coli E22 (1-477/479)
M
S
VPV
Q
HP
M
Y
I
D
G
QFVTWRGD
---
AWIDVV
NPAT
EAV
I
SRIPD
G
QAE
D
A
R
K
A
I
D
AA
ERA
Q
--PE
W
EALP
A
IE
R
ASW
L
R
K
IS
A
G
I
R
ERAS
E
I
S
A
L
I
VE
E
G
GK
-IQQLAEV
E
V
AFTADYID
Y
M
A
E
WARRYE
G
EIIQSD
---
--RPGENILLF
K
R
A
LGV
T
T
G
I
L
PWNFP
FF
L
IA
R
K
MA
PAL
LT
GN
T
I
V
I
KPSE
F
TP
N
N
A
I
AF
A
K
I
VD
E
I
G
L
P
R
GV
F
N
L
V
L
G
R
G
ETV
G
QE
L
A
G
N
P
K
V
AM
VS
M
TGS
VS
A
G
E
K
I
MAT
A
-
A
K
NI
T
K
V
C
LELGGK
A
P
A
IV
MD
D
-
AD
-----
L
E
L
A
VKAIVDSRVI
N
S
GQVC
NCAE
RV
YVQKGIY
D
Q
F
VNRLGEAMQAV
Q
F
G
NPAERN
D
IAM
GPL
I
N
A
A
A
L
E
R
V
EQK
V
AR
A
VEE
G
-
AR
V
AL
G
G
--
KAVE
G
--
-
-
K
GY
YYP
PTL
LLDVRQEMS
I
MH
EE
T
FGPVL
P
V
VAFDTL
EEAI
SM
ANDS
D
YGL
T
S
S
I
Y
T
Q
N
L
NV
A
M
K
A
I
KG
LK
F
G
ET
Y
I
N
RENFEAMQG
F
H
A
G
W
R
K
SG
I
G
GAD
G
KHG
L
HE
Y
LQT
Q
V
V
Y
L
fig|340185.4.peg.1100
Escherichia coli E22 (1-477/479)
M
S
VPV
Q
HP
M
Y
I
D
G
QFVTWRGD
---
AWIDVV
NPAT
EAV
I
SRIPD
G
QAE
D
A
R
K
A
I
D
AA
ERA
Q
--PE
W
EALP
A
IE
R
ASW
L
R
K
IS
A
G
I
R
ERAS
E
I
S
A
L
I
VE
E
G
GK
-IQQLAEV
E
V
AFTADYID
Y
M
A
E
WARRYE
G
EIIQSD
---
--RPGENILLF
K
R
A
LGV
T
T
G
I
L
PWNFP
FF
L
IA
R
K
MA
PAL
LT
GN
T
I
V
I
KPSE
F
TP
N
N
A
I
AF
A
K
I
VD
E
I
G
L
P
R
GV
F
N
L
V
L
G
R
G
ETV
G
QE
L
A
G
N
P
K
V
AM
VS
M
TGS
VS
A
G
E
K
I
MAT
A
-
A
K
NI
T
K
V
C
LELGGK
A
P
A
IV
MD
D
-
AD
-----
L
E
L
A
VKAIVDSRVI
N
S
GQVC
NCAE
RV
YVQKGIY
D
Q
F
VNRLGEAMQAV
Q
F
G
NPAERN
D
IAM
GPL
I
N
A
A
A
L
E
R
V
EQK
V
AR
A
VEE
G
-
AR
V
AL
G
G
--
KAVE
G
--
-
-
K
GY
YYP
PTL
LLDVRQEMS
I
MH
EE
T
FGPVL
P
V
VAFDTL
EEAI
SM
ANDS
D
YGL
T
S
S
I
Y
T
Q
N
L
NV
A
M
K
A
I
KG
LK
F
G
ET
Y
I
N
RENFEAMQG
F
H
A
G
W
R
K
SG
I
G
GAD
G
KHG
L
HE
Y
LQT
Q
V
V
Y
L
fig|585034.4.peg.1400
Escherichia coli IAI1 (1-477/479)
M
S
VPV
Q
HP
M
Y
I
D
G
QFVTWRGD
---
AWIDVV
NPAT
EAV
I
SRIPD
G
QAE
D
A
R
K
A
I
D
AA
ERA
Q
--PE
W
EALP
A
IE
R
ASW
L
R
K
IS
A
G
I
R
ERAS
E
I
S
A
L
I
VE
E
G
GK
-IQQLAEV
E
V
AFTADYID
Y
M
A
E
WARRYE
G
EIIQSD
---
--RPGENILLF
K
R
A
LGV
T
T
G
I
L
PWNFP
FF
L
IA
R
K
MA
PAL
LT
GN
T
I
V
I
KPSE
F
TP
N
N
A
I
AF
A
K
I
VD
E
I
G
L
P
R
GV
F
N
L
V
L
G
R
G
ETV
G
QE
L
A
G
N
P
K
V
AM
VS
M
TGS
VS
A
G
E
K
I
MAT
A
-
A
K
NI
T
K
V
C
LELGGK
A
P
A
IV
MD
D
-
AD
-----
L
E
L
A
VKAIVDSRVI
N
S
GQVC
NCAE
RV
YVQKGIY
D
Q
F
VNRLGEAMQAV
Q
F
G
NPAERN
D
IAM
GPL
I
N
A
A
A
L
E
R
V
EQK
V
AR
A
VEE
G
-
AR
V
AL
G
G
--
KAVE
G
--
-
-
K
GY
YYP
PTL
LLDVRQEMS
I
MH
EE
T
FGPVL
P
V
VAFDTL
EEAI
SM
ANDS
D
YGL
T
S
S
I
Y
T
Q
N
L
NV
A
M
K
A
I
KG
LK
F
G
ET
Y
I
N
RENFEAMQG
F
H
A
G
W
R
K
SG
I
G
GAD
G
KHG
L
HE
Y
LQT
Q
V
V
Y
L
fig|585034.5.peg.1396
Escherichia coli IAI1 (1-477/479)
M
S
VPV
Q
HP
M
Y
I
D
G
QFVTWRGD
---
AWIDVV
NPAT
EAV
I
SRIPD
G
QAE
D
A
R
K
A
I
D
AA
ERA
Q
--PE
W
EALP
A
IE
R
ASW
L
R
K
IS
A
G
I
R
ERAS
E
I
S
A
L
I
VE
E
G
GK
-IQQLAEV
E
V
AFTADYID
Y
M
A
E
WARRYE
G
EIIQSD
---
--RPGENILLF
K
R
A
LGV
T
T
G
I
L
PWNFP
FF
L
IA
R
K
MA
PAL
LT
GN
T
I
V
I
KPSE
F
TP
N
N
A
I
AF
A
K
I
VD
E
I
G
L
P
R
GV
F
N
L
V
L
G
R
G
ETV
G
QE
L
A
G
N
P
K
V
AM
VS
M
TGS
VS
A
G
E
K
I
MAT
A
-
A
K
NI
T
K
V
C
LELGGK
A
P
A
IV
MD
D
-
AD
-----
L
E
L
A
VKAIVDSRVI
N
S
GQVC
NCAE
RV
YVQKGIY
D
Q
F
VNRLGEAMQAV
Q
F
G
NPAERN
D
IAM
GPL
I
N
A
A
A
L
E
R
V
EQK
V
AR
A
VEE
G
-
AR
V
AL
G
G
--
KAVE
G
--
-
-
K
GY
YYP
PTL
LLDVRQEMS
I
MH
EE
T
FGPVL
P
V
VAFDTL
EEAI
SM
ANDS
D
YGL
T
S
S
I
Y
T
Q
N
L
NV
A
M
K
A
I
KG
LK
F
G
ET
Y
I
N
RENFEAMQG
F
H
A
G
W
R
K
SG
I
G
GAD
G
KHG
L
HE
Y
LQT
Q
V
V
Y
L
fig|679207.4.peg.4636
Escherichia coli MS 107-1 (1-477/479)
M
S
VPV
Q
HP
M
Y
I
D
G
QFVTWRGD
---
AWIDVV
NPAT
EAV
I
SRIPD
G
QAE
D
A
R
K
A
I
D
AA
ERA
Q
--PE
W
EALP
A
IE
R
ASW
L
R
K
IS
A
G
I
R
ERAS
E
I
S
A
L
I
VE
E
G
GK
-IQQLAEV
E
V
AFTADYID
Y
M
A
E
WARRYE
G
EIIQSD
---
--RPGENILLF
K
R
A
LGV
T
T
G
I
L
PWNFP
FF
L
IA
R
K
MA
PAL
LT
GN
T
I
V
I
KPSE
F
TP
N
N
A
I
AF
A
K
I
VD
E
I
G
L
P
R
GV
F
N
L
V
L
G
R
G
ETV
G
QE
L
A
G
N
P
K
V
AM
VS
M
TGS
VS
A
G
E
K
I
MAT
A
-
A
K
NI
T
K
V
C
LELGGK
A
P
A
IV
MD
D
-
AD
-----
L
E
L
A
VKAIVDSRVI
N
S
GQVC
NCAE
RV
YVQKGIY
D
Q
F
VNRLGEAMQAV
Q
F
G
NPAERN
D
IAM
GPL
I
N
A
A
A
L
E
R
V
EQK
V
AR
A
VEE
G
-
AR
V
AL
G
G
--
KAVE
G
--
-
-
K
GY
YYP
PTL
LLDVRQEMS
I
MH
EE
T
FGPVL
P
V
VAFDTL
EEAI
SM
ANDS
D
YGL
T
S
S
I
Y
T
Q
N
L
NV
A
M
K
A
I
KG
LK
F
G
ET
Y
I
N
RENFEAMQG
F
H
A
G
W
R
K
SG
I
G
GAD
G
KHG
L
HE
Y
LQT
Q
V
V
Y
L
fig|679204.3.peg.4217
Escherichia coli MS 145-7 (1-477/479)
M
S
VPV
Q
HP
M
Y
I
D
G
QFVTWRGD
---
AWIDVV
NPAT
EAV
I
SRIPD
G
QAE
D
A
R
K
A
I
D
AA
ERA
Q
--PE
W
EALP
A
IE
R
ASW
L
R
K
IS
A
G
I
R
ERAS
E
I
S
A
L
I
VE
E
G
GK
-IQQLAEV
E
V
AFTADYID
Y
M
A
E
WARRYE
G
EIIQSD
---
--RPGENILLF
K
R
A
LGV
T
T
G
I
L
PWNFP
FF
L
IA
R
K
MA
PAL
LT
GN
T
I
V
I
KPSE
F
TP
N
N
A
I
AF
A
K
I
VD
E
I
G
L
P
R
GV
F
N
L
V
L
G
R
G
ETV
G
QE
L
A
G
N
P
K
V
AM
VS
M
TGS
VS
A
G
E
K
I
MAT
A
-
A
K
NI
T
K
V
C
LELGGK
A
P
A
IV
MD
D
-
AD
-----
L
E
L
A
VKAIVDSRVI
N
S
GQVC
NCAE
RV
YVQKGIY
D
Q
F
VNRLGEAMQAV
Q
F
G
NPAERN
D
IAM
GPL
I
N
A
A
A
L
E
R
V
EQK
V
AR
A
VEE
G
-
AR
V
AL
G
G
--
KAVE
G
--
-
-
K
GY
YYP
PTL
LLDVRQEMS
I
MH
EE
T
FGPVL
P
V
VAFDTL
EEAI
SM
ANDS
D
YGL
T
S
S
I
Y
T
Q
N
L
NV
A
M
K
A
I
KG
LK
F
G
ET
Y
I
N
RENFEAMQG
F
H
A
G
W
R
K
SG
I
G
GAD
G
KHG
L
HE
Y
LQT
Q
V
V
Y
L
fig|749532.3.peg.1700
Escherichia coli MS 78-1 (1-477/479)
M
S
VPV
Q
HP
M
Y
I
D
G
QFVTWRGD
---
AWIDVV
NPAT
EAV
I
SRIPD
G
QAE
D
A
R
K
A
I
D
AA
ERA
Q
--PE
W
EALP
A
IE
R
ASW
L
R
K
IS
A
G
I
R
ERAS
E
I
S
A
L
I
VE
E
G
GK
-IQQLAEV
E
V
AFTADYID
Y
M
A
E
WARRYE
G
EIIQSD
---
--RPGENILLF
K
R
A
LGV
T
T
G
I
L
PWNFP
FF
L
IA
R
K
MA
PAL
LT
GN
T
I
V
I
KPSE
F
TP
N
N
A
I
AF
A
K
I
VD
E
I
G
L
P
R
GV
F
N
L
V
L
G
R
G
ETV
G
QE
L
A
G
N
P
K
V
AM
VS
M
TGS
VS
A
G
E
K
I
MAT
A
-
A
K
NI
T
K
V
C
LELGGK
A
P
A
IV
MD
D
-
AD
-----
L
E
L
A
VKAIVDSRVI
N
S
GQVC
NCAE
RV
YVQKGIY
D
Q
F
VNRLGEAMQAV
Q
F
G
NPAERN
D
IAM
GPL
I
N
A
A
A
L
E
R
V
EQK
V
AR
A
VEE
G
-
AR
V
AL
G
G
--
KAVE
G
--
-
-
K
GY
YYP
PTL
LLDVRQEMS
I
MH
EE
T
FGPVL
P
V
VAFDTL
EEAI
SM
ANDS
D
YGL
T
S
S
I
Y
T
Q
N
L
NV
A
M
K
A
I
KG
LK
F
G
ET
Y
I
N
RENFEAMQG
F
H
A
G
W
R
K
SG
I
G
GAD
G
KHG
L
HE
Y
LQT
Q
V
V
Y
L
fig|585395.4.peg.1623
Escherichia coli O103:H2 str. 12009 (1-477/479)
M
S
VPV
Q
HP
M
Y
I
D
G
QFVTWRGD
---
AWIDVV
NPAT
EAV
I
SRIPD
G
QAE
D
A
R
K
A
I
D
AA
ERA
Q
--PE
W
EALP
A
IE
R
ASW
L
R
K
IS
A
G
I
R
ERAS
E
I
S
A
L
I
VE
E
G
GK
-IQQLAEV
E
V
AFTADYID
Y
M
A
E
WARRYE
G
EIIQSD
---
--RPGENILLF
K
R
A
LGV
T
T
G
I
L
PWNFP
FF
L
IA
R
K
MA
PAL
LT
GN
T
I
V
I
KPSE
F
TP
N
N
A
I
AF
A
K
I
VD
E
I
G
L
P
R
GV
F
N
L
V
L
G
R
G
ETV
G
QE
L
A
G
N
P
K
V
AM
VS
M
TGS
VS
A
G
E
K
I
MAT
A
-
A
K
NI
T
K
V
C
LELGGK
A
P
A
IV
MD
D
-
AD
-----
L
E
L
A
VKAIVDSRVI
N
S
GQVC
NCAE
RV
YVQKGIY
D
Q
F
VNRLGEAMQAV
Q
F
G
NPAERN
D
IAM
GPL
I
N
A
A
A
L
E
R
V
EQK
V
AR
A
VEE
G
-
AR
V
AL
G
G
--
KAVE
G
--
-
-
K
GY
YYP
PTL
LLDVRQEMS
I
MH
EE
T
FGPVL
P
V
VAFDTL
EEAI
SM
ANDS
D
YGL
T
S
S
I
Y
T
Q
N
L
NV
A
M
K
A
I
KG
LK
F
G
ET
Y
I
N
RENFEAMQG
F
H
A
G
W
R
K
SG
I
G
GAD
G
KHG
L
HE
Y
LQT
Q
V
V
Y
L
fig|409438.11.peg.1641
Escherichia coli SE11 (1-477/479)
M
S
VPV
Q
HP
M
Y
I
D
G
QFVTWRGD
---
AWIDVV
NPAT
EAV
I
SRIPD
G
QAE
D
A
R
K
A
I
D
AA
ERA
Q
--PE
W
EALP
A
IE
R
ASW
L
R
K
IS
A
G
I
R
ERAS
E
I
S
A
L
I
VE
E
G
GK
-IQQLAEV
E
V
AFTADYID
Y
M
A
E
WARRYE
G
EIIQSD
---
--RPGENILLF
K
R
A
LGV
T
T
G
I
L
PWNFP
FF
L
IA
R
K
MA
PAL
LT
GN
T
I
V
I
KPSE
F
TP
N
N
A
I
AF
A
K
I
VD
E
I
G
L
P
R
GV
F
N
L
V
L
G
R
G
ETV
G
QE
L
A
G
N
P
K
V
AM
VS
M
TGS
VS
A
G
E
K
I
MAT
A
-
A
K
NI
T
K
V
C
LELGGK
A
P
A
IV
MD
D
-
AD
-----
L
E
L
A
VKAIVDSRVI
N
S
GQVC
NCAE
RV
YVQKGIY
D
Q
F
VNRLGEAMQAV
Q
F
G
NPAERN
D
IAM
GPL
I
N
A
A
A
L
E
R
V
EQK
V
AR
A
VEE
G
-
AR
V
AL
G
G
--
KAVE
G
--
-
-
K
GY
YYP
PTL
LLDVRQEMS
I
MH
EE
T
FGPVL
P
V
VAFDTL
EEAI
SM
ANDS
D
YGL
T
S
S
I
Y
T
Q
N
L
NV
A
M
K
A
I
KG
LK
F
G
ET
Y
I
N
RENFEAMQG
F
H
A
G
W
R
K
SG
I
G
GAD
G
KHG
L
HE
Y
LQT
Q
V
V
Y
L
fig|656437.3.peg.1627
Escherichia coli TA143 (1-477/479)
M
S
VPV
Q
HP
M
Y
I
D
G
QFVTWRGD
---
AWIDVV
NPAT
EAV
I
SRIPD
G
QAE
D
A
R
K
A
I
D
AA
ERA
Q
--PE
W
EALP
A
IE
R
ASW
L
R
K
IS
A
G
I
R
KRAS
E
I
S
T
L
I
VE
E
G
GK
-IQQLAEV
E
V
AFTADYID
Y
M
A
E
WARRYE
G
EIIQSD
---
--RPGENILLF
K
R
A
LGV
T
T
G
I
L
PWNFP
FF
L
IA
R
K
MA
PAL
LT
GN
T
I
V
I
KPSE
F
TP
N
N
A
I
AF
A
K
I
VD
E
I
G
L
P
R
GV
F
N
L
V
L
G
R
G
ETV
G
QE
L
A
G
N
P
K
V
AM
VS
M
TGS
VS
A
G
E
K
I
MAT
A
-
A
K
NI
T
K
V
C
LELGGK
A
P
A
IV
MD
D
-
AD
-----
L
E
L
A
VKAIVDSRVI
N
S
GQVC
NCAE
RV
YVQKGIY
D
Q
F
VNRLGEAMQAV
Q
F
G
NPVERN
D
IAM
GPL
I
N
A
A
A
L
E
R
V
EQK
V
AR
A
VEE
G
-
AR
V
AL
G
G
--
KAVE
G
--
-
-
K
GY
YYP
PTL
LLDVRQEMS
I
MH
EE
T
FGPVL
P
V
VAFDTL
E
D
AI
AM
ANDS
D
YGL
T
S
S
I
Y
T
Q
N
L
NV
A
M
K
A
I
KG
LK
F
G
ET
Y
I
N
RENFEAMQG
F
H
A
G
W
R
K
SG
I
G
GAD
G
KHG
L
HE
Y
LQT
Q
V
V
Y
L
fig|656444.3.peg.2196
Escherichia coli TA280 (1-477/479)
M
S
VPV
Q
HP
M
Y
I
D
G
QFVTWRGD
---
AWIDVI
NPAT
EAV
I
SRIPD
G
QAE
D
A
R
K
A
I
D
AA
ERA
Q
--PE
W
EALP
A
IE
R
ASW
L
R
K
IS
A
G
I
R
ERAS
E
I
S
A
L
I
VE
E
G
GK
-IQQLAEV
E
V
AFTADYID
Y
M
A
E
WARRYE
G
EIIQSD
---
--RPGEKILLF
K
R
A
LGV
T
T
G
I
L
PWNFP
FF
L
IA
R
K
MA
PAL
LT
GN
T
I
V
I
KPSE
F
TP
N
N
A
I
AF
A
K
I
VD
E
I
G
L
P
R
GV
F
N
L
V
L
G
R
G
ETV
G
QE
L
A
G
N
P
K
V
AM
VS
M
TGS
VS
A
G
E
K
I
MAT
A
-
A
K
NI
T
K
V
C
LELGGK
A
P
A
IV
MD
D
-
AD
-----
L
E
L
A
VKAIVDSRVI
N
S
GQVC
NCAE
RV
YVQKDIY
D
Q
F
VNRLGEAMQAV
Q
F
G
NPAERN
D
IAM
GPL
I
N
A
A
A
L
E
R
V
EQK
V
AR
A
VEE
G
-
AR
V
AL
G
G
--
KAVE
G
--
-
-
K
GY
YYP
PTL
LLDVRQEMS
I
MH
EE
T
FGPVL
P
V
VAFDTL
EEAI
SM
ANDS
D
YGL
T
S
S
I
Y
T
Q
N
L
NV
A
M
K
A
I
KG
LK
F
G
ET
Y
I
N
RENFEAMQG
F
H
A
G
W
R
K
SG
I
G
GAD
G
KHG
L
HE
Y
LQT
Q
V
V
Y
L
fig|358709.5.peg.902
Escherichia coli 101-1 (1-477/479)
M
S
VPV
Q
HP
M
Y
I
D
G
QFVTWRGD
---
AWIDVV
NPAT
EAV
I
SRIPD
G
QAE
D
A
R
K
A
I
D
AA
ERA
Q
--PE
W
EALP
A
IE
R
ASW
L
R
K
IS
A
G
I
R
ERAS
E
I
S
A
L
I
VE
E
G
GK
-IQQLAEV
E
V
AFTADYID
Y
M
A
E
WARRYE
G
EIIQSD
---
--RPGENILLF
K
R
A
LGV
T
T
G
I
L
PWNFP
FF
L
IA
R
K
MA
PAL
LT
GN
T
I
V
I
KPSE
F
TP
N
N
A
I
AF
A
K
I
VD
E
I
G
L
P
R
GV
F
N
L
V
L
G
R
G
ETV
G
QE
L
A
G
N
P
K
V
AM
VS
M
TGS
VS
A
G
E
K
I
MAT
A
-
A
K
NI
T
K
V
C
LELGGK
A
P
A
IV
MD
D
-
AD
-----
L
E
L
A
VKAIVDSRVI
N
S
GQVC
NCAE
R
I
YVQKGIY
D
Q
F
VNRLGEAMQAV
Q
F
G
NPAERN
D
IAM
GPL
I
N
A
A
A
L
E
R
V
EQK
V
AR
A
VEE
G
-
AR
V
AL
G
G
--
KAVE
G
--
-
-
K
GY
YYP
PTL
LLDVLQEMS
I
MH
EE
T
FGPVL
P
V
VAFDTL
EEAI
SM
ANDS
D
YGL
T
S
S
I
Y
T
Q
N
L
NV
A
M
K
A
I
KG
LK
F
G
ET
Y
I
N
RENFEAMQG
F
H
A
G
W
R
K
SG
I
G
GAD
G
KHG
L
HE
Y
LQT
Q
V
V
Y
L
fig|413997.3.peg.1443
Escherichia coli B str. REL606 (1-477/479)
M
S
VPV
Q
HP
M
Y
I
D
G
QFVTWRGD
---
AWIDVV
NPAT
EAV
I
SRIPD
G
QAE
D
A
R
K
A
I
D
AA
ERA
Q
--PE
W
EALP
A
IE
R
ASW
L
R
K
IS
A
G
I
R
ERAS
E
I
S
A
L
I
VE
E
G
GK
-IQQLAEV
E
V
AFTADYID
Y
M
A
E
WARRYE
G
EIIQSD
---
--RPGENILLF
K
R
A
LGV
T
T
G
I
L
PWNFP
FF
L
IA
R
K
MA
PAL
LT
GN
T
I
V
I
KPSE
F
TP
N
N
A
I
AF
A
K
I
VD
E
I
G
L
P
R
GV
F
N
L
V
L
G
R
G
ETV
G
QE
L
A
G
N
P
K
V
AM
VS
M
TGS
VS
A
G
E
K
I
MAT
A
-
A
K
NI
T
K
V
C
LELGGK
A
P
A
IV
MD
D
-
AD
-----
L
E
L
A
VKAIVDSRVI
N
S
GQVC
NCAE
R
I
YVQKGIY
D
Q
F
VNRLGEAMQAV
Q
F
G
NPAERN
D
IAM
GPL
I
N
A
A
A
L
E
R
V
EQK
V
AR
A
VEE
G
-
AR
V
AL
G
G
--
KAVE
G
--
-
-
K
GY
YYP
PTL
LLDVLQEMS
I
MH
EE
T
FGPVL
P
V
VAFDTL
EEAI
SM
ANDS
D
YGL
T
S
S
I
Y
T
Q
N
L
NV
A
M
K
A
I
KG
LK
F
G
ET
Y
I
N
RENFEAMQG
F
H
A
G
W
R
K
SG
I
G
GAD
G
KHG
L
HE
Y
LQT
Q
V
V
Y
L
fig|511693.5.peg.1482
Escherichia coli BL21 (1-477/479)
M
S
VPV
Q
HP
M
Y
I
D
G
QFVTWRGD
---
AWIDVV
NPAT
EAV
I
SRIPD
G
QAE
D
A
R
K
A
I
D
AA
ERA
Q
--PE
W
EALP
A
IE
R
ASW
L
R
K
IS
A
G
I
R
ERAS
E
I
S
A
L
I
VE
E
G
GK
-IQQLAEV
E
V
AFTADYID
Y
M
A
E
WARRYE
G
EIIQSD
---
--RPGENILLF
K
R
A
LGV
T
T
G
I
L
PWNFP
FF
L
IA
R
K
MA
PAL
LT
GN
T
I
V
I
KPSE
F
TP
N
N
A
I
AF
A
K
I
VD
E
I
G
L
P
R
GV
F
N
L
V
L
G
R
G
ETV
G
QE
L
A
G
N
P
K
V
AM
VS
M
TGS
VS
A
G
E
K
I
MAT
A
-
A
K
NI
T
K
V
C
LELGGK
A
P
A
IV
MD
D
-
AD
-----
L
E
L
A
VKAIVDSRVI
N
S
GQVC
NCAE
R
I
YVQKGIY
D
Q
F
VNRLGEAMQAV
Q
F
G
NPAERN
D
IAM
GPL
I
N
A
A
A
L
E
R
V
EQK
V
AR
A
VEE
G
-
AR
V
AL
G
G
--
KAVE
G
--
-
-
K
GY
YYP
PTL
LLDVLQEMS
I
MH
EE
T
FGPVL
P
V
VAFDTL
EEAI
SM
ANDS
D
YGL
T
S
S
I
Y
T
Q
N
L
NV
A
M
K
A
I
KG
LK
F
G
ET
Y
I
N
RENFEAMQG
F
H
A
G
W
R
K
SG
I
G
GAD
G
KHG
L
HE
Y
LQT
Q
V
V
Y
L
fig|469008.4.peg.2292
Escherichia coli BL21(DE3) (1-477/479)
M
S
VPV
Q
HP
M
Y
I
D
G
QFVTWRGD
---
AWIDVV
NPAT
EAV
I
SRIPD
G
QAE
D
A
R
K
A
I
D
AA
ERA
Q
--PE
W
EALP
A
IE
R
ASW
L
R
K
IS
A
G
I
R
ERAS
E
I
S
A
L
I
VE
E
G
GK
-IQQLAEV
E
V
AFTADYID
Y
M
A
E
WARRYE
G
EIIQSD
---
--RPGENILLF
K
R
A
LGV
T
T
G
I
L
PWNFP
FF
L
IA
R
K
MA
PAL
LT
GN
T
I
V
I
KPSE
F
TP
N
N
A
I
AF
A
K
I
VD
E
I
G
L
P
R
GV
F
N
L
V
L
G
R
G
ETV
G
QE
L
A
G
N
P
K
V
AM
VS
M
TGS
VS
A
G
E
K
I
MAT
A
-
A
K
NI
T
K
V
C
LELGGK
A
P
A
IV
MD
D
-
AD
-----
L
E
L
A
VKAIVDSRVI
N
S
GQVC
NCAE
R
I
YVQKGIY
D
Q
F
VNRLGEAMQAV
Q
F
G
NPAERN
D
IAM
GPL
I
N
A
A
A
L
E
R
V
EQK
V
AR
A
VEE
G
-
AR
V
AL
G
G
--
KAVE
G
--
-
-
K
GY
YYP
PTL
LLDVLQEMS
I
MH
EE
T
FGPVL
P
V
VAFDTL
EEAI
SM
ANDS
D
YGL
T
S
S
I
Y
T
Q
N
L
NV
A
M
K
A
I
KG
LK
F
G
ET
Y
I
N
RENFEAMQG
F
H
A
G
W
R
K
SG
I
G
GAD
G
KHG
L
HE
Y
LQT
Q
V
V
Y
L
fig|749547.3.peg.54
Escherichia coli MS 187-1 (1-477/479)
M
S
VPV
Q
HP
M
Y
I
D
G
QFVTWRGD
---
AWIDVV
NPAT
EAV
I
SRIPD
G
QAE
D
A
R
K
A
I
D
AA
ERA
Q
--PE
W
EALP
A
IE
R
ASW
L
R
K
IS
A
G
I
R
ERAS
E
I
S
A
L
I
VE
E
G
GK
-IQQLAEV
E
V
AFTADYID
Y
M
A
E
WARRYE
G
EIIQSD
---
--RPGENILLF
K
R
A
LGV
T
T
G
I
L
PWNFP
FF
L
IA
R
K
MA
PAL
LT
GN
T
I
V
I
KPSE
F
TP
N
N
A
I
AF
A
K
I
VD
E
I
G
L
P
R
GV
F
N
L
V
L
G
R
G
ETV
G
QE
L
A
G
N
P
K
V
AM
VS
M
TGS
VS
A
G
E
K
I
MAT
A
-
A
K
NI
T
K
V
C
LELGGK
A
P
A
IV
MD
D
-
AD
-----
L
E
L
A
VKAIVDSRVI
N
S
GQVC
NCAE
R
I
YVQKGIY
D
Q
F
VNRLGEAMQAV
Q
F
G
NPAERN
D
IAM
GPL
I
N
A
A
A
L
E
R
V
EQK
V
AR
A
VEE
G
-
AR
V
AL
G
G
--
KAVE
G
--
-
-
K
GY
YYP
PTL
LLDVLQEMS
I
MH
EE
T
FGPVL
P
V
VAFDTL
EEAI
SM
ANDS
D
YGL
T
S
S
I
Y
T
Q
N
L
NV
A
M
K
A
I
KG
LK
F
G
ET
Y
I
N
RENFEAMQG
F
H
A
G
W
R
K
SG
I
G
GAD
G
KHG
L
HE
Y
LQT
Q
V
V
Y
L
fig|749545.3.peg.1109
Escherichia coli MS 182-1 (1-477/479)
M
S
VPV
Q
HP
M
Y
I
D
G
QFVTWRGD
---
AWIDVV
NPAT
EAV
I
SRIPD
G
QAE
D
A
R
K
A
I
D
AA
ERA
Q
--PE
W
EALP
A
IE
R
ASW
L
R
K
IS
A
G
I
R
ERAS
E
I
S
A
L
I
VE
E
G
GK
-IQQLAEV
E
V
AFTADYID
Y
M
A
E
WARRYE
G
EIIQSD
---
--RPGENILLF
K
R
A
LGV
T
T
G
I
L
PWNFP
FF
L
IA
R
K
MA
PAL
LT
GN
T
I
V
I
KPSE
F
TP
N
N
A
I
AF
A
K
I
VD
E
I
G
L
P
R
GV
F
N
L
V
L
G
R
G
ETV
G
QE
L
A
G
N
P
K
V
AM
VS
M
TGS
VS
A
G
E
K
I
MAT
A
-
A
K
NI
T
K
V
C
LELGGK
A
P
A
IV
MD
D
-
AD
-----
L
E
L
A
VKAIVDSRVI
N
S
GQVC
NCAE
RV
YVQKGIY
D
Q
F
VNRLGEAMQAV
Q
F
G
NPAERN
D
IAM
GPL
I
N
A
A
A
L
E
R
V
EQK
V
AR
A
VEE
G
-
AR
V
AL
G
G
--
KAVE
G
--
-
-
K
GY
YYP
PTL
LLDVRQEMS
I
MH
EE
S
FGPVL
P
V
VAFDTL
EEAI
SM
ANDS
D
YGL
T
S
S
I
Y
T
Q
N
L
NV
A
M
K
A
I
KG
LK
F
G
ET
Y
I
N
RENFEAMQG
F
H
A
G
W
R
K
SG
I
G
GAD
G
KHG
L
HE
Y
LQT
Q
V
V
Y
L
fig|562.371.peg.1798
Escherichia coli 1044A (1-477/479)
M
S
VPV
Q
HP
M
Y
I
D
G
QFVTWRGD
---
AWIDVV
NPAT
EAV
I
SRIPD
G
QAE
D
A
R
K
A
I
D
AA
ERA
Q
--PE
W
EALP
A
IE
R
ASW
L
R
K
IS
A
G
I
R
ERAS
E
I
S
A
L
I
VE
E
G
GK
-IQQLAEV
E
V
AFTADYID
Y
M
A
E
WARRYE
G
EIIQSD
---
--RPGENILLF
K
R
A
LGV
T
T
G
I
L
PWNFP
FF
L
IA
R
K
MA
PAL
LT
GN
T
I
V
I
KPSE
F
TP
N
N
A
I
AF
A
K
I
VD
E
I
G
L
P
R
GV
F
N
L
V
L
G
R
G
ETV
G
QE
L
A
G
N
P
K
V
AM
VS
M
TGS
VS
A
G
E
K
I
MAT
A
-
A
K
NI
T
K
V
C
LELGGK
A
P
A
IV
MD
D
-
AD
-----
L
E
L
A
VKAIVDSRVI
N
S
GQVC
NCAE
RV
YVQKGIY
D
Q
F
VNRLGEAMQAV
Q
F
G
NPAERN
D
IAM
GPL
I
N
A
A
A
L
E
R
V
EQK
V
AR
A
VEE
G
-
AR
V
AL
G
G
--
KAVE
G
--
-
-
K
GY
YYP
PTL
LLDVRQEMS
I
MH
EE
T
FGPVL
P
V
VAFDTL
E
D
AI
SM
ANDS
D
YGL
T
S
S
I
Y
T
Q
N
L
NV
A
M
K
A
I
KG
LK
F
G
ET
Y
I
N
RENFEAMQG
F
H
A
G
W
R
K
SG
I
G
GAD
G
KHG
L
HE
Y
LQT
Q
V
V
Y
L
fig|562.373.peg.5145
Escherichia coli 1125A (1-477/479)
M
S
VPV
Q
HP
M
Y
I
D
G
QFVTWRGD
---
AWIDVV
NPAT
EAV
I
SRIPD
G
QAE
D
A
R
K
A
I
D
AA
ERA
Q
--PE
W
EALP
A
IE
R
ASW
L
R
K
IS
A
G
I
R
ERAS
E
I
S
A
L
I
VE
E
G
GK
-IQQLAEV
E
V
AFTADYID
Y
M
A
E
WARRYE
G
EIIQSD
---
--RPGENILLF
K
R
A
LGV
T
T
G
I
L
PWNFP
FF
L
IA
R
K
MA
PAL
LT
GN
T
I
V
I
KPSE
F
TP
N
N
A
I
AF
A
K
I
VD
E
I
G
L
P
R
GV
F
N
L
V
L
G
R
G
ETV
G
QE
L
A
G
N
P
K
V
AM
VS
M
TGS
VS
A
G
E
K
I
MAT
A
-
A
K
NI
T
K
V
C
LELGGK
A
P
A
IV
MD
D
-
AD
-----
L
E
L
A
VKAIVDSRVI
N
S
GQVC
NCAE
RV
YVQKGIY
D
Q
F
VNRLGEAMQAV
Q
F
G
NPAERN
D
IAM
GPL
I
N
A
A
A
L
E
R
V
EQK
V
AR
A
VEE
G
-
AR
V
AL
G
G
--
KAVE
G
--
-
-
K
GY
YYP
PTL
LLDVRQEMS
I
MH
EE
T
FGPVL
P
V
VAFDTL
E
D
AI
SM
ANDS
D
YGL
T
S
S
I
Y
T
Q
N
L
NV
A
M
K
A
I
KG
LK
F
G
ET
Y
I
N
RENFEAMQG
F
H
A
G
W
R
K
SG
I
G
GAD
G
KHG
L
HE
Y
LQT
Q
V
V
Y
L
fig|562.372.peg.1283
Escherichia coli 1212A (1-477/479)
M
S
VPV
Q
HP
M
Y
I
D
G
QFVTWRGD
---
AWIDVV
NPAT
EAV
I
SRIPD
G
QAE
D
A
R
K
A
I
D
AA
ERA
Q
--PE
W
EALP
A
IE
R
ASW
L
R
K
IS
A
G
I
R
ERAS
E
I
S
A
L
I
VE
E
G
GK
-IQQLAEV
E
V
AFTADYID
Y
M
A
E
WARRYE
G
EIIQSD
---
--RPGENILLF
K
R
A
LGV
T
T
G
I
L
PWNFP
FF
L
IA
R
K
MA
PAL
LT
GN
T
I
V
I
KPSE
F
TP
N
N
A
I
AF
A
K
I
VD
E
I
G
L
P
R
GV
F
N
L
V
L
G
R
G
ETV
G
QE
L
A
G
N
P
K
V
AM
VS
M
TGS
VS
A
G
E
K
I
MAT
A
-
A
K
NI
T
K
V
C
LELGGK
A
P
A
IV
MD
D
-
AD
-----
L
E
L
A
VKAIVDSRVI
N
S
GQVC
NCAE
RV
YVQKGIY
D
Q
F
VNRLGEAMQAV
Q
F
G
NPAERN
D
IAM
GPL
I
N
A
A
A
L
E
R
V
EQK
V
AR
A
VEE
G
-
AR
V
AL
G
G
--
KAVE
G
--
-
-
K
GY
YYP
PTL
LLDVRQEMS
I
MH
EE
T
FGPVL
P
V
VAFDTL
E
D
AI
SM
ANDS
D
YGL
T
S
S
I
Y
T
Q
N
L
NV
A
M
K
A
I
KG
LK
F
G
ET
Y
I
N
RENFEAMQG
F
H
A
G
W
R
K
SG
I
G
GAD
G
KHG
L
HE
Y
LQT
Q
V
V
Y
L
fig|562.374.peg.2302
Escherichia coli 536A (1-477/479)
M
S
VPV
Q
HP
M
Y
I
D
G
QFVTWRGD
---
AWIDVV
NPAT
EAV
I
SRIPD
G
QAE
D
A
R
K
A
I
D
AA
ERA
Q
--PE
W
EALP
A
IE
R
ASW
L
R
K
IS
A
G
I
R
ERAS
E
I
S
A
L
I
VE
E
G
GK
-IQQLAEV
E
V
AFTADYID
Y
M
A
E
WARRYE
G
EIIQSD
---
--RPGENILLF
K
R
A
LGV
T
T
G
I
L
PWNFP
FF
L
IA
R
K
MA
PAL
LT
GN
T
I
V
I
KPSE
F
TP
N
N
A
I
AF
A
K
I
VD
E
I
G
L
P
R
GV
F
N
L
V
L
G
R
G
ETV
G
QE
L
A
G
N
P
K
V
AM
VS
M
TGS
VS
A
G
E
K
I
MAT
A
-
A
K
NI
T
K
V
C
LELGGK
A
P
A
IV
MD
D
-
AD
-----
L
E
L
A
VKAIVDSRVI
N
S
GQVC
NCAE
RV
YVQKGIY
D
Q
F
VNRLGEAMQAV
Q
F
G
NPAERN
D
IAM
GPL
I
N
A
A
A
L
E
R
V
EQK
V
AR
A
VEE
G
-
AR
V
AL
G
G
--
KAVE
G
--
-
-
K
GY
YYP
PTL
LLDVRQEMS
I
MH
EE
T
FGPVL
P
V
VAFDTL
E
D
AI
SM
ANDS
D
YGL
T
S
S
I
Y
T
Q
N
L
NV
A
M
K
A
I
KG
LK
F
G
ET
Y
I
N
RENFEAMQG
F
H
A
G
W
R
K
SG
I
G
GAD
G
KHG
L
HE
Y
LQT
Q
V
V
Y
L
fig|83334.1.peg.2050
Escherichia coli O157:H7 (1-477/479)
M
S
VPV
Q
HP
M
Y
I
D
G
QFVTWRGD
---
AWIDVV
NPAT
EAV
I
SRIPD
G
QAE
D
A
R
K
A
I
D
AA
ERA
Q
--PE
W
EALP
A
IE
R
ASW
L
R
K
IS
A
G
I
R
ERAS
E
I
S
A
L
I
VE
E
G
GK
-IQQLAEV
E
V
AFTADYID
Y
M
A
E
WARRYE
G
EIIQSD
---
--RPGENILLF
K
R
A
LGV
T
T
G
I
L
PWNFP
FF
L
IA
R
K
MA
PAL
LT
GN
T
I
V
I
KPSE
F
TP
N
N
A
I
AF
A
K
I
VD
E
I
G
L
P
R
GV
F
N
L
V
L
G
R
G
ETV
G
QE
L
A
G
N
P
K
V
AM
VS
M
TGS
VS
A
G
E
K
I
MAT
A
-
A
K
NI
T
K
V
C
LELGGK
A
P
A
IV
MD
D
-
AD
-----
L
E
L
A
VKAIVDSRVI
N
S
GQVC
NCAE
RV
YVQKGIY
D
Q
F
VNRLGEAMQAV
Q
F
G
NPAERN
D
IAM
GPL
I
N
A
A
A
L
E
R
V
EQK
V
AR
A
VEE
G
-
AR
V
AL
G
G
--
KAVE
G
--
-
-
K
GY
YYP
PTL
LLDVRQEMS
I
MH
EE
T
FGPVL
P
V
VAFDTL
E
D
AI
SM
ANDS
D
YGL
T
S
S
I
Y
T
Q
N
L
NV
A
M
K
A
I
KG
LK
F
G
ET
Y
I
N
RENFEAMQG
F
H
A
G
W
R
K
SG
I
G
GAD
G
KHG
L
HE
Y
LQT
Q
V
V
Y
L
fig|155864.1.peg.2054
Escherichia coli O157:H7 EDL933 (1-477/479)
M
S
VPV
Q
HP
M
Y
I
D
G
QFVTWRGD
---
AWIDVV
NPAT
EAV
I
SRIPD
G
QAE
D
A
R
K
A
I
D
AA
ERA
Q
--PE
W
EALP
A
IE
R
ASW
L
R
K
IS
A
G
I
R
ERAS
E
I
S
A
L
I
VE
E
G
GK
-IQQLAEV
E
V
AFTADYID
Y
M
A
E
WARRYE
G
EIIQSD
---
--RPGENILLF
K
R
A
LGV
T
T
G
I
L
PWNFP
FF
L
IA
R
K
MA
PAL
LT
GN
T
I
V
I
KPSE
F
TP
N
N
A
I
AF
A
K
I
VD
E
I
G
L
P
R
GV
F
N
L
V
L
G
R
G
ETV
G
QE
L
A
G
N
P
K
V
AM
VS
M
TGS
VS
A
G
E
K
I
MAT
A
-
A
K
NI
T
K
V
C
LELGGK
A
P
A
IV
MD
D
-
AD
-----
L
E
L
A
VKAIVDSRVI
N
S
GQVC
NCAE
RV
YVQKGIY
D
Q
F
VNRLGEAMQAV
Q
F
G
NPAERN
D
IAM
GPL
I
N
A
A
A
L
E
R
V
EQK
V
AR
A
VEE
G
-
AR
V
AL
G
G
--
KAVE
G
--
-
-
K
GY
YYP
PTL
LLDVRQEMS
I
MH
EE
T
FGPVL
P
V
VAFDTL
E
D
AI
SM
ANDS
D
YGL
T
S
S
I
Y
T
Q
N
L
NV
A
M
K
A
I
KG
LK
F
G
ET
Y
I
N
RENFEAMQG
F
H
A
G
W
R
K
SG
I
G
GAD
G
KHG
L
HE
Y
LQT
Q
V
V
Y
L
fig|155864.8.peg.1880
Escherichia coli O157:H7 EDL933 (1-477/479)
M
S
VPV
Q
HP
M
Y
I
D
G
QFVTWRGD
---
AWIDVV
NPAT
EAV
I
SRIPD
G
QAE
D
A
R
K
A
I
D
AA
ERA
Q
--PE
W
EALP
A
IE
R
ASW
L
R
K
IS
A
G
I
R
ERAS
E
I
S
A
L
I
VE
E
G
GK
-IQQLAEV
E
V
AFTADYID
Y
M
A
E
WARRYE
G
EIIQSD
---
--RPGENILLF
K
R
A
LGV
T
T
G
I
L
PWNFP
FF
L
IA
R
K
MA
PAL
LT
GN
T
I
V
I
KPSE
F
TP
N
N
A
I
AF
A
K
I
VD
E
I
G
L
P
R
GV
F
N
L
V
L
G
R
G
ETV
G
QE
L
A
G
N
P
K
V
AM
VS
M
TGS
VS
A
G
E
K
I
MAT
A
-
A
K
NI
T
K
V
C
LELGGK
A
P
A
IV
MD
D
-
AD
-----
L
E
L
A
VKAIVDSRVI
N
S
GQVC
NCAE
RV
YVQKGIY
D
Q
F
VNRLGEAMQAV
Q
F
G
NPAERN
D
IAM
GPL
I
N
A
A
A
L
E
R
V
EQK
V
AR
A
VEE
G
-
AR
V
AL
G
G
--
KAVE
G
--
-
-
K
GY
YYP
PTL
LLDVRQEMS
I
MH
EE
T
FGPVL
P
V
VAFDTL
E
D
AI
SM
ANDS
D
YGL
T
S
S
I
Y
T
Q
N
L
NV
A
M
K
A
I
KG
LK
F
G
ET
Y
I
N
RENFEAMQG
F
H
A
G
W
R
K
SG
I
G
GAD
G
KHG
L
HE
Y
LQT
Q
V
V
Y
L
fig|444454.5.peg.352
Escherichia coli O157:H7 str. EC4024 (1-477/479)
M
S
VPV
Q
HP
M
Y
I
D
G
QFVTWRGD
---
AWIDVV
NPAT
EAV
I
SRIPD
G
QAE
D
A
R
K
A
I
D
AA
ERA
Q
--PE
W
EALP
A
IE
R
ASW
L
R
K
IS
A
G
I
R
ERAS
E
I
S
A
L
I
VE
E
G
GK
-IQQLAEV
E
V
AFTADYID
Y
M
A
E
WARRYE
G
EIIQSD
---
--RPGENILLF
K
R
A
LGV
T
T
G
I
L
PWNFP
FF
L
IA
R
K
MA
PAL
LT
GN
T
I
V
I
KPSE
F
TP
N
N
A
I
AF
A
K
I
VD
E
I
G
L
P
R
GV
F
N
L
V
L
G
R
G
ETV
G
QE
L
A
G
N
P
K
V
AM
VS
M
TGS
VS
A
G
E
K
I
MAT
A
-
A
K
NI
T
K
V
C
LELGGK
A
P
A
IV
MD
D
-
AD
-----
L
E
L
A
VKAIVDSRVI
N
S
GQVC
NCAE
RV
YVQKGIY
D
Q
F
VNRLGEAMQAV
Q
F
G
NPAERN
D
IAM
GPL
I
N
A
A
A
L
E
R
V
EQK
V
AR
A
VEE
G
-
AR
V
AL
G
G
--
KAVE
G
--
-
-
K
GY
YYP
PTL
LLDVRQEMS
I
MH
EE
T
FGPVL
P
V
VAFDTL
E
D
AI
SM
ANDS
D
YGL
T
S
S
I
Y
T
Q
N
L
NV
A
M
K
A
I
KG
LK
F
G
ET
Y
I
N
RENFEAMQG
F
H
A
G
W
R
K
SG
I
G
GAD
G
KHG
L
HE
Y
LQT
Q
V
V
Y
L
fig|444449.5.peg.252
Escherichia coli O157:H7 str. EC4042 (1-477/479)
M
S
VPV
Q
HP
M
Y
I
D
G
QFVTWRGD
---
AWIDVV
NPAT
EAV
I
SRIPD
G
QAE
D
A
R
K
A
I
D
AA
ERA
Q
--PE
W
EALP
A
IE
R
ASW
L
R
K
IS
A
G
I
R
ERAS
E
I
S
A
L
I
VE
E
G
GK
-IQQLAEV
E
V
AFTADYID
Y
M
A
E
WARRYE
G
EIIQSD
---
--RPGENILLF
K
R
A
LGV
T
T
G
I
L
PWNFP
FF
L
IA
R
K
MA
PAL
LT
GN
T
I
V
I
KPSE
F
TP
N
N
A
I
AF
A
K
I
VD
E
I
G
L
P
R
GV
F
N
L
V
L
G
R
G
ETV
G
QE
L
A
G
N
P
K
V
AM
VS
M
TGS
VS
A
G
E
K
I
MAT
A
-
A
K
NI
T
K
V
C
LELGGK
A
P
A
IV
MD
D
-
AD
-----
L
E
L
A
VKAIVDSRVI
N
S
GQVC
NCAE
RV
YVQKGIY
D
Q
F
VNRLGEAMQAV
Q
F
G
NPAERN
D
IAM
GPL
I
N
A
A
A
L
E
R
V
EQK
V
AR
A
VEE
G
-
AR
V
AL
G
G
--
KAVE
G
--
-
-
K
GY
YYP
PTL
LLDVRQEMS
I
MH
EE
T
FGPVL
P
V
VAFDTL
E
D
AI
SM
ANDS
D
YGL
T
S
S
I
Y
T
Q
N
L
NV
A
M
K
A
I
KG
LK
F
G
ET
Y
I
N
RENFEAMQG
F
H
A
G
W
R
K
SG
I
G
GAD
G
KHG
L
HE
Y
LQT
Q
V
V
Y
L
fig|444448.5.peg.4608
Escherichia coli O157:H7 str. EC4045 (1-477/479)
M
S
VPV
Q
HP
M
Y
I
D
G
QFVTWRGD
---
AWIDVV
NPAT
EAV
I
SRIPD
G
QAE
D
A
R
K
A
I
D
AA
ERA
Q
--PE
W
EALP
A
IE
R
ASW
L
R
K
IS
A
G
I
R
ERAS
E
I
S
A
L
I
VE
E
G
GK
-IQQLAEV
E
V
AFTADYID
Y
M
A
E
WARRYE
G
EIIQSD
---
--RPGENILLF
K
R
A
LGV
T
T
G
I
L
PWNFP
FF
L
IA
R
K
MA
PAL
LT
GN
T
I
V
I
KPSE
F
TP
N
N
A
I
AF
A
K
I
VD
E
I
G
L
P
R
GV
F
N
L
V
L
G
R
G
ETV
G
QE
L
A
G
N
P
K
V
AM
VS
M
TGS
VS
A
G
E
K
I
MAT
A
-
A
K
NI
T
K
V
C
LELGGK
A
P
A
IV
MD
D
-
AD
-----
L
E
L
A
VKAIVDSRVI
N
S
GQVC
NCAE
RV
YVQKGIY
D
Q
F
VNRLGEAMQAV
Q
F
G
NPAERN
D
IAM
GPL
I
N
A
A
A
L
E
R
V
EQK
V
AR
A
VEE
G
-
AR
V
AL
G
G
--
KAVE
G
--
-
-
K
GY
YYP
PTL
LLDVRQEMS
I
MH
EE
T
FGPVL
P
V
VAFDTL
E
D
AI
SM
ANDS
D
YGL
T
S
S
I
Y
T
Q
N
L
NV
A
M
K
A
I
KG
LK
F
G
ET
Y
I
N
RENFEAMQG
F
H
A
G
W
R
K
SG
I
G
GAD
G
KHG
L
HE
Y
LQT
Q
V
V
Y
L
fig|444453.5.peg.4217
Escherichia coli O157:H7 str. EC4076 (1-477/479)
M
S
VPV
Q
HP
M
Y
I
D
G
QFVTWRGD
---
AWIDVV
NPAT
EAV
I
SRIPD
G
QAE
D
A
R
K
A
I
D
AA
ERA
Q
--PE
W
EALP
A
IE
R
ASW
L
R
K
IS
A
G
I
R
ERAS
E
I
S
A
L
I
VE
E
G
GK
-IQQLAEV
E
V
AFTADYID
Y
M
A
E
WARRYE
G
EIIQSD
---
--RPGENILLF
K
R
A
LGV
T
T
G
I
L
PWNFP
FF
L
IA
R
K
MA
PAL
LT
GN
T
I
V
I
KPSE
F
TP
N
N
A
I
AF
A
K
I
VD
E
I
G
L
P
R
GV
F
N
L
V
L
G
R
G
ETV
G
QE
L
A
G
N
P
K
V
AM
VS
M
TGS
VS
A
G
E
K
I
MAT
A
-
A
K
NI
T
K
V
C
LELGGK
A
P
A
IV
MD
D
-
AD
-----
L
E
L
A
VKAIVDSRVI
N
S
GQVC
NCAE
RV
YVQKGIY
D
Q
F
VNRLGEAMQAV
Q
F
G
NPAERN
D
IAM
GPL
I
N
A
A
A
L
E
R
V
EQK
V
AR
A
VEE
G
-
AR
V
AL
G
G
--
KAVE
G
--
-
-
K
GY
YYP
PTL
LLDVRQEMS
I
MH
EE
T
FGPVL
P
V
VAFDTL
E
D
AI
SM
ANDS
D
YGL
T
S
S
I
Y
T
Q
N
L
NV
A
M
K
A
I
KG
LK
F
G
ET
Y
I
N
RENFEAMQG
F
H
A
G
W
R
K
SG
I
G
GAD
G
KHG
L
HE
Y
LQT
Q
V
V
Y
L
fig|444452.5.peg.2015
Escherichia coli O157:H7 str. EC4113 (1-477/479)
M
S
VPV
Q
HP
M
Y
I
D
G
QFVTWRGD
---
AWIDVV
NPAT
EAV
I
SRIPD
G
QAE
D
A
R
K
A
I
D
AA
ERA
Q
--PE
W
EALP
A
IE
R
ASW
L
R
K
IS
A
G
I
R
ERAS
E
I
S
A
L
I
VE
E
G
GK
-IQQLAEV
E
V
AFTADYID
Y
M
A
E
WARRYE
G
EIIQSD
---
--RPGENILLF
K
R
A
LGV
T
T
G
I
L
PWNFP
FF
L
IA
R
K
MA
PAL
LT
GN
T
I
V
I
KPSE
F
TP
N
N
A
I
AF
A
K
I
VD
E
I
G
L
P
R
GV
F
N
L
V
L
G
R
G
ETV
G
QE
L
A
G
N
P
K
V
AM
VS
M
TGS
VS
A
G
E
K
I
MAT
A
-
A
K
NI
T
K
V
C
LELGGK
A
P
A
IV
MD
D
-
AD
-----
L
E
L
A
VKAIVDSRVI
N
S
GQVC
NCAE
RV
YVQKGIY
D
Q
F
VNRLGEAMQAV
Q
F
G
NPAERN
D
IAM
GPL
I
N
A
A
A
L
E
R
V
EQK
V
AR
A
VEE
G
-
AR
V
AL
G
G
--
KAVE
G
--
-
-
K
GY
YYP
PTL
LLDVRQEMS
I
MH
EE
T
FGPVL
P
V
VAFDTL
E
D
AI
SM
ANDS
D
YGL
T
S
S
I
Y
T
Q
N
L
NV
A
M
K
A
I
KG
LK
F
G
ET
Y
I
N
RENFEAMQG
F
H
A
G
W
R
K
SG
I
G
GAD
G
KHG
L
HE
Y
LQT
Q
V
V
Y
L
fig|444450.8.peg.2070
Escherichia coli O157:H7 str. EC4115 (1-477/479)
M
S
VPV
Q
HP
M
Y
I
D
G
QFVTWRGD
---
AWIDVV
NPAT
EAV
I
SRIPD
G
QAE
D
A
R
K
A
I
D
AA
ERA
Q
--PE
W
EALP
A
IE
R
ASW
L
R
K
IS
A
G
I
R
ERAS
E
I
S
A
L
I
VE
E
G
GK
-IQQLAEV
E
V
AFTADYID
Y
M
A
E
WARRYE
G
EIIQSD
---
--RPGENILLF
K
R
A
LGV
T
T
G
I
L
PWNFP
FF
L
IA
R
K
MA
PAL
LT
GN
T
I
V
I
KPSE
F
TP
N
N
A
I
AF
A
K
I
VD
E
I
G
L
P
R
GV
F
N
L
V
L
G
R
G
ETV
G
QE
L
A
G
N
P
K
V
AM
VS
M
TGS
VS
A
G
E
K
I
MAT
A
-
A
K
NI
T
K
V
C
LELGGK
A
P
A
IV
MD
D
-
AD
-----
L
E
L
A
VKAIVDSRVI
N
S
GQVC
NCAE
RV
YVQKGIY
D
Q
F
VNRLGEAMQAV
Q
F
G
NPAERN
D
IAM
GPL
I
N
A
A
A
L
E
R
V
EQK
V
AR
A
VEE
G
-
AR
V
AL
G
G
--
KAVE
G
--
-
-
K
GY
YYP
PTL
LLDVRQEMS
I
MH
EE
T
FGPVL
P
V
VAFDTL
E
D
AI
SM
ANDS
D
YGL
T
S
S
I
Y
T
Q
N
L
NV
A
M
K
A
I
KG
LK
F
G
ET
Y
I
N
RENFEAMQG
F
H
A
G
W
R
K
SG
I
G
GAD
G
KHG
L
HE
Y
LQT
Q
V
V
Y
L
fig|444451.5.peg.4660
Escherichia coli O157:H7 str. EC4196 (1-477/479)
M
S
VPV
Q
HP
M
Y
I
D
G
QFVTWRGD
---
AWIDVV
NPAT
EAV
I
SRIPD
G
QAE
D
A
R
K
A
I
D
AA
ERA
Q
--PE
W
EALP
A
IE
R
ASW
L
R
K
IS
A
G
I
R
ERAS
E
I
S
A
L
I
VE
E
G
GK
-IQQLAEV
E
V
AFTADYID
Y
M
A
E
WARRYE
G
EIIQSD
---
--RPGENILLF
K
R
A
LGV
T
T
G
I
L
PWNFP
FF
L
IA
R
K
MA
PAL
LT
GN
T
I
V
I
KPSE
F
TP
N
N
A
I
AF
A
K
I
VD
E
I
G
L
P
R
GV
F
N
L
V
L
G
R
G
ETV
G
QE
L
A
G
N
P
K
V
AM
VS
M
TGS
VS
A
G
E
K
I
MAT
A
-
A
K
NI
T
K
V
C
LELGGK
A
P
A
IV
MD
D
-
AD
-----
L
E
L
A
VKAIVDSRVI
N
S
GQVC
NCAE
RV
YVQKGIY
D
Q
F
VNRLGEAMQAV
Q
F
G
NPAERN
D
IAM
GPL
I
N
A
A
A
L
E
R
V
EQK
V
AR
A
VEE
G
-
AR
V
AL
G
G
--
KAVE
G
--
-
-
K
GY
YYP
PTL
LLDVRQEMS
I
MH
EE
T
FGPVL
P
V
VAFDTL
E
D
AI
SM
ANDS
D
YGL
T
S
S
I
Y
T
Q
N
L
NV
A
M
K
A
I
KG
LK
F
G
ET
Y
I
N
RENFEAMQG
F
H
A
G
W
R
K
SG
I
G
GAD
G
KHG
L
HE
Y
LQT
Q
V
V
Y
L
fig|444447.5.peg.5517
Escherichia coli O157:H7 str. EC4206 (1-477/479)
M
S
VPV
Q
HP
M
Y
I
D
G
QFVTWRGD
---
AWIDVV
NPAT
EAV
I
SRIPD
G
QAE
D
A
R
K
A
I
D
AA
ERA
Q
--PE
W
EALP
A
IE
R
ASW
L
R
K
IS
A
G
I
R
ERAS
E
I
S
A
L
I
VE
E
G
GK
-IQQLAEV
E
V
AFTADYID
Y
M
A
E
WARRYE
G
EIIQSD
---
--RPGENILLF
K
R
A
LGV
T
T
G
I
L
PWNFP
FF
L
IA
R
K
MA
PAL
LT
GN
T
I
V
I
KPSE
F
TP
N
N
A
I
AF
A
K
I
VD
E
I
G
L
P
R
GV
F
N
L
V
L
G
R
G
ETV
G
QE
L
A
G
N
P
K
V
AM
VS
M
TGS
VS
A
G
E
K
I
MAT
A
-
A
K
NI
T
K
V
C
LELGGK
A
P
A
IV
MD
D
-
AD
-----
L
E
L
A
VKAIVDSRVI
N
S
GQVC
NCAE
RV
YVQKGIY
D
Q
F
VNRLGEAMQAV
Q
F
G
NPAERN
D
IAM
GPL
I
N
A
A
A
L
E
R
V
EQK
V
AR
A
VEE
G
-
AR
V
AL
G
G
--
KAVE
G
--
-
-
K
GY
YYP
PTL
LLDVRQEMS
I
MH
EE
T
FGPVL
P
V
VAFDTL
E
D
AI
SM
ANDS
D
YGL
T
S
S
I
Y
T
Q
N
L
NV
A
M
K
A
I
KG
LK
F
G
ET
Y
I
N
RENFEAMQG
F
H
A
G
W
R
K
SG
I
G
GAD
G
KHG
L
HE
Y
LQT
Q
V
V
Y
L
fig|478004.5.peg.2799
Escherichia coli O157:H7 str. EC4401 (1-477/479)
M
S
VPV
Q
HP
M
Y
I
D
G
QFVTWRGD
---
AWIDVV
NPAT
EAV
I
SRIPD
G
QAE
D
A
R
K
A
I
D
AA
ERA
Q
--PE
W
EALP
A
IE
R
ASW
L
R
K
IS
A
G
I
R
ERAS
E
I
S
A
L
I
VE
E
G
GK
-IQQLAEV
E
V
AFTADYID
Y
M
A
E
WARRYE
G
EIIQSD
---
--RPGENILLF
K
R
A
LGV
T
T
G
I
L
PWNFP
FF
L
IA
R
K
MA
PAL
LT
GN
T
I
V
I
KPSE
F
TP
N
N
A
I
AF
A
K
I
VD
E
I
G
L
P
R
GV
F
N
L
V
L
G
R
G
ETV
G
QE
L
A
G
N
P
K
V
AM
VS
M
TGS
VS
A
G
E
K
I
MAT
A
-
A
K
NI
T
K
V
C
LELGGK
A
P
A
IV
MD
D
-
AD
-----
L
E
L
A
VKAIVDSRVI
N
S
GQVC
NCAE
RV
YVQKGIY
D
Q
F
VNRLGEAMQAV
Q
F
G
NPAERN
D
IAM
GPL
I
N
A
A
A
L
E
R
V
EQK
V
AR
A
VEE
G
-
AR
V
AL
G
G
--
KAVE
G
--
-
-
K
GY
YYP
PTL
LLDVRQEMS
I
MH
EE
T
FGPVL
P
V
VAFDTL
E
D
AI
SM
ANDS
D
YGL
T
S
S
I
Y
T
Q
N
L
NV
A
M
K
A
I
KG
LK
F
G
ET
Y
I
N
RENFEAMQG
F
H
A
G
W
R
K
SG
I
G
GAD
G
KHG
L
HE
Y
LQT
Q
V
V
Y
L
fig|478006.5.peg.3514
Escherichia coli O157:H7 str. EC4501 (1-477/479)
M
S
VPV
Q
HP
M
Y
I
D
G
QFVTWRGD
---
AWIDVV
NPAT
EAV
I
SRIPD
G
QAE
D
A
R
K
A
I
D
AA
ERA
Q
--PE
W
EALP
A
IE
R
ASW
L
R
K
IS
A
G
I
R
ERAS
E
I
S
A
L
I
VE
E
G
GK
-IQQLAEV
E
V
AFTADYID
Y
M
A
E
WARRYE
G
EIIQSD
---
--RPGENILLF
K
R
A
LGV
T
T
G
I
L
PWNFP
FF
L
IA
R
K
MA
PAL
LT
GN
T
I
V
I
KPSE
F
TP
N
N
A
I
AF
A
K
I
VD
E
I
G
L
P
R
GV
F
N
L
V
L
G
R
G
ETV
G
QE
L
A
G
N
P
K
V
AM
VS
M
TGS
VS
A
G
E
K
I
MAT
A
-
A
K
NI
T
K
V
C
LELGGK
A
P
A
IV
MD
D
-
AD
-----
L
E
L
A
VKAIVDSRVI
N
S
GQVC
NCAE
RV
YVQKGIY
D
Q
F
VNRLGEAMQAV
Q
F
G
NPAERN
D
IAM
GPL
I
N
A
A
A
L
E
R
V
EQK
V
AR
A
VEE
G
-
AR
V
AL
G
G
--
KAVE
G
--
-
-
K
GY
YYP
PTL
LLDVRQEMS
I
MH
EE
T
FGPVL
P
V
VAFDTL
E
D
AI
SM
ANDS
D
YGL
T
S
S
I
Y
T
Q
N
L
NV
A
M
K
A
I
KG
LK
F
G
ET
Y
I
N
RENFEAMQG
F
H
A
G
W
R
K
SG
I
G
GAD
G
KHG
L
HE
Y
LQT
Q
V
V
Y
L
fig|478007.5.peg.2418
Escherichia coli O157:H7 str. EC508 (1-477/479)
M
S
VPV
Q
HP
M
Y
I
D
G
QFVTWRGD
---
AWIDVV
NPAT
EAV
I
SRIPD
G
QAE
D
A
R
K
A
I
D
AA
ERA
Q
--PE
W
EALP
A
IE
R
ASW
L
R
K
IS
A
G
I
R
ERAS
E
I
S
A
L
I
VE
E
G
GK
-IQQLAEV
E
V
AFTADYID
Y
M
A
E
WARRYE
G
EIIQSD
---
--RPGENILLF
K
R
A
LGV
T
T
G
I
L
PWNFP
FF
L
IA
R
K
MA
PAL
LT
GN
T
I
V
I
KPSE
F
TP
N
N
A
I
AF
A
K
I
VD
E
I
G
L
P
R
GV
F
N
L
V
L
G
R
G
ETV
G
QE
L
A
G
N
P
K
V
AM
VS
M
TGS
VS
A
G
E
K
I
MAT
A
-
A
K
NI
T
K
V
C
LELGGK
A
P
A
IV
MD
D
-
AD
-----
L
E
L
A
VKAIVDSRVI
N
S
GQVC
NCAE
RV
YVQKGIY
D
Q
F
VNRLGEAMQAV
Q
F
G
NPAERN
D
IAM
GPL
I
N
A
A
A
L
E
R
V
EQK
V
AR
A
VEE
G
-
AR
V
AL
G
G
--
KAVE
G
--
-
-
K
GY
YYP
PTL
LLDVRQEMS
I
MH
EE
T
FGPVL
P
V
VAFDTL
E
D
AI
SM
ANDS
D
YGL
T
S
S
I
Y
T
Q
N
L
NV
A
M
K
A
I
KG
LK
F
G
ET
Y
I
N
RENFEAMQG
F
H
A
G
W
R
K
SG
I
G
GAD
G
KHG
L
HE
Y
LQT
Q
V
V
Y
L
fig|478008.5.peg.3489
Escherichia coli O157:H7 str. EC869 (1-477/479)
M
S
VPV
Q
HP
M
Y
I
D
G
QFVTWRGD
---
AWIDVV
NPAT
EAV
I
SRIPD
G
QAE
D
A
R
K
A
I
D
AA
ERA
Q
--PE
W
EALP
A
IE
R
ASW
L
R
K
IS
A
G
I
R
ERAS
E
I
S
A
L
I
VE
E
G
GK
-IQQLAEV
E
V
AFTADYID
Y
M
A
E
WARRYE
G
EIIQSD
---
--RPGENILLF
K
R
A
LGV
T
T
G
I
L
PWNFP
FF
L
IA
R
K
MA
PAL
LT
GN
T
I
V
I
KPSE
F
TP
N
N
A
I
AF
A
K
I
VD
E
I
G
L
P
R
GV
F
N
L
V
L
G
R
G
ETV
G
QE
L
A
G
N
P
K
V
AM
VS
M
TGS
VS
A
G
E
K
I
MAT
A
-
A
K
NI
T
K
V
C
LELGGK
A
P
A
IV
MD
D
-
AD
-----
L
E
L
A
VKAIVDSRVI
N
S
GQVC
NCAE
RV
YVQKGIY
D
Q
F
VNRLGEAMQAV
Q
F
G
NPAERN
D
IAM
GPL
I
N
A
A
A
L
E
R
V
EQK
V
AR
A
VEE
G
-
AR
V
AL
G
G
--
KAVE
G
--
-
-
K
GY
YYP
PTL
LLDVRQEMS
I
MH
EE
T
FGPVL
P
V
VAFDTL
E
D
AI
SM
ANDS
D
YGL
T
S
S
I
Y
T
Q
N
L
NV
A
M
K
A
I
KG
LK
F
G
ET
Y
I
N
RENFEAMQG
F
H
A
G
W
R
K
SG
I
G
GAD
G
KHG
L
HE
Y
LQT
Q
V
V
Y
L
fig|637388.3.peg.1441
Escherichia coli O157:H7 str. FRIK2000 (1-477/479)
M
S
VPV
Q
HP
M
Y
I
D
G
QFVTWRGD
---
AWIDVV
NPAT
EAV
I
SRIPD
G
QAE
D
A
R
K
A
I
D
AA
ERA
Q
--PE
W
EALP
A
IE
R
ASW
L
R
K
IS
A
G
I
R
ERAS
E
I
S
A
L
I
VE
E
G
GK
-IQQLAEV
E
V
AFTADYID
Y
M
A
E
WARRYE
G
EIIQSD
---
--RPGENILLF
K
R
A
LGV
T
T
G
I
L
PWNFP
FF
L
IA
R
K
MA
PAL
LT
GN
T
I
V
I
KPSE
F
TP
N
N
A
I
AF
A
K
I
VD
E
I
G
L
P
R
GV
F
N
L
V
L
G
R
G
ETV
G
QE
L
A
G
N
P
K
V
AM
VS
M
TGS
VS
A
G
E
K
I
MAT
A
-
A
K
NI
T
K
V
C
LELGGK
A
P
A
IV
MD
D
-
AD
-----
L
E
L
A
VKAIVDSRVI
N
S
GQVC
NCAE
RV
YVQKGIY
D
Q
F
VNRLGEAMQAV
Q
F
G
NPAERN
D
IAM
GPL
I
N
A
A
A
L
E
R
V
EQK
V
AR
A
VEE
G
-
AR
V
AL
G
G
--
KAVE
G
--
-
-
K
GY
YYP
PTL
LLDVRQEMS
I
MH
EE
T
FGPVL
P
V
VAFDTL
E
D
AI
SM
ANDS
D
YGL
T
S
S
I
Y
T
Q
N
L
NV
A
M
K
A
I
KG
LK
F
G
ET
Y
I
N
RENFEAMQG
F
H
A
G
W
R
K
SG
I
G
GAD
G
KHG
L
HE
Y
LQT
Q
V
V
Y
L
fig|570506.3.peg.3272
Escherichia coli O157:H7 str. FRIK966 (1-477/479)
M
S
VPV
Q
HP
M
Y
I
D
G
QFVTWRGD
---
AWIDVV
NPAT
EAV
I
SRIPD
G
QAE
D
A
R
K
A
I
D
AA
ERA
Q
--PE
W
EALP
A
IE
R
ASW
L
R
K
IS
A
G
I
R
ERAS
E
I
S
A
L
I
VE
E
G
GK
-IQQLAEV
E
V
AFTADYID
Y
M
A
E
WARRYE
G
EIIQSD
---
--RPGENILLF
K
R
A
LGV
T
T
G
I
L
PWNFP
FF
L
IA
R
K
MA
PAL
LT
GN
T
I
V
I
KPSE
F
TP
N
N
A
I
AF
A
K
I
VD
E
I
G
L
P
R
GV
F
N
L
V
L
G
R
G
ETV
G
QE
L
A
G
N
P
K
V
AM
VS
M
TGS
VS
A
G
E
K
I
MAT
A
-
A
K
NI
T
K
V
C
LELGGK
A
P
A
IV
MD
D
-
AD
-----
L
E
L
A
VKAIVDSRVI
N
S
GQVC
NCAE
RV
YVQKGIY
D
Q
F
VNRLGEAMQAV
Q
F
G
NPAERN
D
IAM
GPL
I
N
A
A
A
L
E
R
V
EQK
V
AR
A
VEE
G
-
AR
V
AL
G
G
--
KAVE
G
--
-
-
K
GY
YYP
PTL
LLDVRQEMS
I
MH
EE
T
FGPVL
P
V
VAFDTL
E
D
AI
SM
ANDS
D
YGL
T
S
S
I
Y
T
Q
N
L
NV
A
M
K
A
I
KG
LK
F
G
ET
Y
I
N
RENFEAMQG
F
H
A
G
W
R
K
SG
I
G
GAD
G
KHG
L
HE
Y
LQT
Q
V
V
Y
L
fig|386585.9.peg.2122
Escherichia coli O157:H7 str. Sakai (1-477/479)
M
S
VPV
Q
HP
M
Y
I
D
G
QFVTWRGD
---
AWIDVV
NPAT
EAV
I
SRIPD
G
QAE
D
A
R
K
A
I
D
AA
ERA
Q
--PE
W
EALP
A
IE
R
ASW
L
R
K
IS
A
G
I
R
ERAS
E
I
S
A
L
I
VE
E
G
GK
-IQQLAEV
E
V
AFTADYID
Y
M
A
E
WARRYE
G
EIIQSD
---
--RPGENILLF
K
R
A
LGV
T
T
G
I
L
PWNFP
FF
L
IA
R
K
MA
PAL
LT
GN
T
I
V
I
KPSE
F
TP
N
N
A
I
AF
A
K
I
VD
E
I
G
L
P
R
GV
F
N
L
V
L
G
R
G
ETV
G
QE
L
A
G
N
P
K
V
AM
VS
M
TGS
VS
A
G
E
K
I
MAT
A
-
A
K
NI
T
K
V
C
LELGGK
A
P
A
IV
MD
D
-
AD
-----
L
E
L
A
VKAIVDSRVI
N
S
GQVC
NCAE
RV
YVQKGIY
D
Q
F
VNRLGEAMQAV
Q
F
G
NPAERN
D
IAM
GPL
I
N
A
A
A
L
E
R
V
EQK
V
AR
A
VEE
G
-
AR
V
AL
G
G
--
KAVE
G
--
-
-
K
GY
YYP
PTL
LLDVRQEMS
I
MH
EE
T
FGPVL
P
V
VAFDTL
E
D
AI
SM
ANDS
D
YGL
T
S
S
I
Y
T
Q
N
L
NV
A
M
K
A
I
KG
LK
F
G
ET
Y
I
N
RENFEAMQG
F
H
A
G
W
R
K
SG
I
G
GAD
G
KHG
L
HE
Y
LQT
Q
V
V
Y
L
fig|544404.4.peg.1931
Escherichia coli O157:H7 str. TW14359 (1-477/479)
M
S
VPV
Q
HP
M
Y
I
D
G
QFVTWRGD
---
AWIDVV
NPAT
EAV
I
SRIPD
G
QAE
D
A
R
K
A
I
D
AA
ERA
Q
--PE
W
EALP
A
IE
R
ASW
L
R
K
IS
A
G
I
R
ERAS
E
I
S
A
L
I
VE
E
G
GK
-IQQLAEV
E
V
AFTADYID
Y
M
A
E
WARRYE
G
EIIQSD
---
--RPGENILLF
K
R
A
LGV
T
T
G
I
L
PWNFP
FF
L
IA
R
K
MA
PAL
LT
GN
T
I
V
I
KPSE
F
TP
N
N
A
I
AF
A
K
I
VD
E
I
G
L
P
R
GV
F
N
L
V
L
G
R
G
ETV
G
QE
L
A
G
N
P
K
V
AM
VS
M
TGS
VS
A
G
E
K
I
MAT
A
-
A
K
NI
T
K
V
C
LELGGK
A
P
A
IV
MD
D
-
AD
-----
L
E
L
A
VKAIVDSRVI
N
S
GQVC
NCAE
RV
YVQKGIY
D
Q
F
VNRLGEAMQAV
Q
F
G
NPAERN
D
IAM
GPL
I
N
A
A
A
L
E
R
V
EQK
V
AR
A
VEE
G
-
AR
V
AL
G
G
--
KAVE
G
--
-
-
K
GY
YYP
PTL
LLDVRQEMS
I
MH
EE
T
FGPVL
P
V
VAFDTL
E
D
AI
SM
ANDS
D
YGL
T
S
S
I
Y
T
Q
N
L
NV
A
M
K
A
I
KG
LK
F
G
ET
Y
I
N
RENFEAMQG
F
H
A
G
W
R
K
SG
I
G
GAD
G
KHG
L
HE
Y
LQT
Q
V
V
Y
L
fig|502346.5.peg.5350
Escherichia coli O157:H7 str. TW14588 (1-477/479)
M
S
VPV
Q
HP
M
Y
I
D
G
QFVTWRGD
---
AWIDVV
NPAT
EAV
I
SRIPD
G
QAE
D
A
R
K
A
I
D
AA
ERA
Q
--PE
W
EALP
A
IE
R
ASW
L
R
K
IS
A
G
I
R
ERAS
E
I
S
A
L
I
VE
E
G
GK
-IQQLAEV
E
V
AFTADYID
Y
M
A
E
WARRYE
G
EIIQSD
---
--RPGENILLF
K
R
A
LGV
T
T
G
I
L
PWNFP
FF
L
IA
R
K
MA
PAL
LT
GN
T
I
V
I
KPSE
F
TP
N
N
A
I
AF
A
K
I
VD
E
I
G
L
P
R
GV
F
N
L
V
L
G
R
G
ETV
G
QE
L
A
G
N
P
K
V
AM
VS
M
TGS
VS
A
G
E
K
I
MAT
A
-
A
K
NI
T
K
V
C
LELGGK
A
P
A
IV
MD
D
-
AD
-----
L
E
L
A
VKAIVDSRVI
N
S
GQVC
NCAE
RV
YVQKGIY
D
Q
F
VNRLGEAMQAV
Q
F
G
NPAERN
D
IAM
GPL
I
N
A
A
A
L
E
R
V
EQK
V
AR
A
VEE
G
-
AR
V
AL
G
G
--
KAVE
G
--
-
-
K
GY
YYP
PTL
LLDVRQEMS
I
MH
EE
T
FGPVL
P
V
VAFDTL
E
D
AI
SM
ANDS
D
YGL
T
S
S
I
Y
T
Q
N
L
NV
A
M
K
A
I
KG
LK
F
G
ET
Y
I
N
RENFEAMQG
F
H
A
G
W
R
K
SG
I
G
GAD
G
KHG
L
HE
Y
LQT
Q
V
V
Y
L
fig|701177.3.peg.1766
Escherichia coli O55:H7 str. CB9615 (1-477/479)
M
S
VPV
Q
HP
M
Y
I
D
G
QFVTWRGD
---
AWIDVV
NPAT
EAV
I
SRIPD
G
QAE
D
A
R
K
A
I
D
AA
ERA
Q
--PE
W
EALP
A
IE
R
ASW
L
R
K
IS
A
G
I
R
ERAS
E
I
S
A
L
I
VE
E
G
GK
-IQQLAEV
E
V
AFTADYID
Y
M
A
E
WARRYE
G
EIIQSD
---
--RPGENILLF
K
R
A
LGV
T
T
G
I
L
PWNFP
FF
L
IA
R
K
MA
PAL
LT
GN
T
I
V
I
KPSE
F
TP
N
N
A
I
AF
A
K
I
VD
E
I
G
L
P
R
GV
F
N
L
V
L
G
R
G
ETV
G
QE
L
A
G
N
P
K
V
AM
VS
M
TGS
VS
A
G
E
K
I
MAT
A
-
A
K
NI
T
K
V
C
LELGGK
A
P
A
IV
MD
D
-
AD
-----
L
E
L
A
VKAIVDSRVI
N
S
GQVC
NCAE
RV
YVQKGIY
D
Q
F
VNRLGEAMQAV
Q
F
G
NPAERN
D
IAM
GPL
I
N
A
A
A
L
E
R
V
EQK
V
AR
A
VEE
G
-
AR
V
AL
G
G
--
KAVE
G
--
-
-
K
GY
YYP
PTL
LLDVRQEMS
I
MH
EE
T
FGPVL
P
V
VAFDTL
E
D
AI
SM
ANDS
D
YGL
T
S
S
I
Y
T
Q
N
L
NV
A
M
K
A
I
KG
LK
F
G
ET
Y
I
N
RENFEAMQG
F
H
A
G
W
R
K
SG
I
G
GAD
G
KHG
L
HE
Y
LQT
Q
V
V
Y
L
fig|656419.3.peg.1987
Escherichia coli M718 (1-477/479)
M
S
VPV
Q
HP
M
Y
I
D
G
QFVTWRGD
---
AWIDVV
NPAT
EAV
I
SRIPD
G
QAE
D
A
R
K
A
I
D
AA
ERA
Q
--PE
W
EALP
A
IE
R
ASW
L
R
K
IS
A
G
I
R
ERAS
E
I
S
A
L
I
VE
E
G
GK
-IQQLAEV
E
V
AFTADYID
Y
M
A
E
WARRYE
G
EIIQSD
---
--RPGENILLF
K
R
A
LGV
T
T
G
I
L
PWNFP
FF
L
IA
R
K
MA
PAL
LT
GN
T
I
V
I
KPSE
F
TP
N
N
A
I
AF
A
K
I
VD
E
I
G
L
P
R
GV
F
N
L
V
L
G
R
G
ETV
G
QE
L
A
G
N
P
K
V
AM
VS
M
TGS
VS
A
G
E
K
I
MAT
A
-
A
K
NI
T
K
V
C
LELGGK
A
P
A
IV
MD
D
-
AD
-----
L
E
L
A
VKAIVDSRVI
N
S
GQVC
NCAE
RV
YVQKGIY
D
Q
F
VNRLGEAMQAV
Q
F
G
NPAERN
D
IAM
GPL
I
N
A
A
A
L
E
R
V
EQK
V
AR
A
VEE
G
-
AR
V
AL
G
G
--
KVVE
G
--
-
-
K
GY
YYP
PTL
LLDVRQEMS
I
MH
EE
T
FGPVL
P
V
VAFDTL
E
D
AI
SM
ANDS
D
YGL
T
S
S
I
Y
T
Q
N
L
NV
A
M
K
A
I
KG
LK
F
G
ET
Y
I
N
RENFEAMQG
F
H
A
G
W
R
K
SG
I
G
GAD
G
KHG
L
HE
Y
LQT
Q
V
V
Y
L
fig|216592.1.peg.1951
Escherichia coli 042 (1-477/479)
M
S
VPV
Q
HP
M
Y
I
D
G
QFVTWRGD
---
AWIDVV
NPAT
EAV
I
SRIPD
G
QAE
D
A
R
K
A
I
D
AA
ERA
Q
--PE
W
EALP
A
IE
R
ASW
L
R
K
IS
A
G
I
R
ERAS
E
I
S
A
L
I
VE
E
G
GK
-IQQLAEV
E
V
AFTADYID
Y
M
A
E
WARRYE
G
EIIQSD
---
--RPGENILLF
K
R
A
LGV
T
T
G
I
L
PWNFP
FF
L
IA
R
K
MA
PAL
LT
GN
T
I
V
I
KPSE
F
TP
N
N
A
I
AF
A
K
I
VD
E
I
G
L
P
R
GV
F
N
L
V
L
G
R
G
ETV
G
QE
L
A
G
N
P
K
V
AM
VS
M
TGS
VS
A
G
E
K
I
MAT
A
-
A
K
NI
T
K
V
C
LELGGK
A
P
A
IV
MD
D
-
AD
-----
L
E
L
A
VKAIVDSRVI
N
S
GQVC
NCAE
RV
YVQKGIY
D
Q
F
VNRLGEAMQAV
Q
F
G
NPAERN
D
IAM
GPL
I
N
A
S
A
L
E
R
V
EQK
V
AR
A
VEE
G
-
AR
V
AL
G
G
--
KAVE
G
--
-
-
K
GY
YYP
PTL
LLDVRQEMS
I
MH
EE
T
FGPVL
P
V
VAFDTL
EEAI
AM
ANDS
D
YGL
T
S
S
I
Y
T
Q
N
L
NV
A
M
K
A
I
KG
LK
F
G
ET
Y
I
N
RENFEAMQG
F
H
A
G
W
R
K
SG
I
G
GAD
G
KHG
L
HE
Y
LQT
Q
V
V
Y
L
fig|216592.3.peg.1605
Escherichia coli 042 (1-477/479)
M
S
VPV
Q
HP
M
Y
I
D
G
QFVTWRGD
---
AWIDVV
NPAT
EAV
I
SRIPD
G
QAE
D
A
R
K
A
I
D
AA
ERA
Q
--PE
W
EALP
A
IE
R
ASW
L
R
K
IS
A
G
I
R
ERAS
E
I
S
A
L
I
VE
E
G
GK
-IQQLAEV
E
V
AFTADYID
Y
M
A
E
WARRYE
G
EIIQSD
---
--RPGENILLF
K
R
A
LGV
T
T
G
I
L
PWNFP
FF
L
IA
R
K
MA
PAL
LT
GN
T
I
V
I
KPSE
F
TP
N
N
A
I
AF
A
K
I
VD
E
I
G
L
P
R
GV
F
N
L
V
L
G
R
G
ETV
G
QE
L
A
G
N
P
K
V
AM
VS
M
TGS
VS
A
G
E
K
I
MAT
A
-
A
K
NI
T
K
V
C
LELGGK
A
P
A
IV
MD
D
-
AD
-----
L
E
L
A
VKAIVDSRVI
N
S
GQVC
NCAE
RV
YVQKGIY
D
Q
F
VNRLGEAMQAV
Q
F
G
NPAERN
D
IAM
GPL
I
N
A
S
A
L
E
R
V
EQK
V
AR
A
VEE
G
-
AR
V
AL
G
G
--
KAVE
G
--
-
-
K
GY
YYP
PTL
LLDVRQEMS
I
MH
EE
T
FGPVL
P
V
VAFDTL
EEAI
AM
ANDS
D
YGL
T
S
S
I
Y
T
Q
N
L
NV
A
M
K
A
I
KG
LK
F
G
ET
Y
I
N
RENFEAMQG
F
H
A
G
W
R
K
SG
I
G
GAD
G
KHG
L
HE
Y
LQT
Q
V
V
Y
L
fig|656379.3.peg.3453
Escherichia coli FVEC1302 (1-477/479)
M
S
VPV
Q
HP
M
Y
I
D
G
QFVTWRGD
---
AWIDVV
NPAT
EAV
I
SRIPD
G
QAE
D
A
R
K
A
I
D
AA
ERA
Q
--PE
W
EALP
A
IE
R
ASW
L
R
K
IS
A
G
I
R
ERAG
E
I
S
A
L
I
VE
E
G
GK
-IQQLAEV
E
V
AFTADYID
Y
M
A
E
WARRYE
G
EIIQSD
---
--RPGENILLF
K
R
A
LGV
T
T
G
I
L
PWNFP
FF
L
IA
R
K
MA
PAL
LT
GN
T
I
V
I
KPSE
F
TP
N
N
A
I
AF
A
K
I
VD
E
I
G
L
P
R
GV
F
N
L
V
L
G
R
G
ETV
G
QE
L
A
G
N
P
K
V
AM
VS
M
TGS
VS
A
G
E
K
I
MAT
A
-
A
K
NI
T
K
V
C
LELGGK
A
P
A
IV
MD
D
-
AD
-----
L
E
L
A
VKAIVDSRVI
N
S
GQVC
NCAE
RV
YVQKGIY
D
Q
F
VNRLGEAMQAV
Q
F
G
NPAERN
D
IAM
GPL
I
N
A
A
A
L
E
R
V
EQK
V
AR
A
VEE
G
-
AR
V
AL
G
G
--
KAVE
G
--
-
-
K
GY
YYP
PTL
LLDVRQEMS
I
MH
EE
T
FGPVL
P
V
VAFDTL
EEAI
SM
ANDS
D
YGL
T
S
S
L
Y
T
Q
N
L
NV
A
M
K
A
I
KG
LK
F
G
ET
Y
I
N
RENFEAMQG
F
H
A
G
W
R
K
SG
I
G
GAD
G
KHG
L
HE
Y
LQT
Q
V
V
Y
L
fig|656380.3.peg.2807
Escherichia coli FVEC1412 (1-477/479)
M
S
VPV
Q
HP
M
Y
I
D
G
QFVTWRGD
---
AWIDVV
NPAT
EAV
I
SRIPD
G
QAE
D
A
R
K
A
I
D
AA
ERA
Q
--PE
W
EALP
A
IE
R
ASW
L
R
K
IS
A
G
I
R
ERAG
E
I
S
A
L
I
VE
E
G
GK
-IQQLAEV
E
V
AFTADYID
Y
M
A
E
WARRYE
G
EIIQSD
---
--RPGENILLF
K
R
A
LGV
T
T
G
I
L
PWNFP
FF
L
IA
R
K
MA
PAL
LT
GN
T
I
V
I
KPSE
F
TP
N
N
A
I
AF
A
K
I
VD
E
I
G
L
P
R
GV
F
N
L
V
L
G
R
G
ETV
G
QE
L
A
G
N
P
K
V
AM
VS
M
TGS
VS
A
G
E
K
I
MAT
A
-
A
K
NI
T
K
V
C
LELGGK
A
P
A
IV
MD
D
-
AD
-----
L
E
L
A
VKAIVDSRVI
N
S
GQVC
NCAE
RV
YVQKGIY
D
Q
F
VNRLGEAMQAV
Q
F
G
NPAERN
D
IAM
GPL
I
N
A
A
A
L
E
R
V
EQK
V
AR
A
VEE
G
-
AR
V
AL
G
G
--
KAVE
G
--
-
-
K
GY
YYP
PTL
LLDVRQEMS
I
MH
EE
T
FGPVL
P
V
VAFDTL
EEAI
SM
ANDS
D
YGL
T
S
S
L
Y
T
Q
N
L
NV
A
M
K
A
I
KG
LK
F
G
ET
Y
I
N
RENFEAMQG
F
H
A
G
W
R
K
SG
I
G
GAD
G
KHG
L
HE
Y
LQT
Q
V
V
Y
L
fig|749549.3.peg.3906
Escherichia coli MS 198-1 (1-477/479)
M
S
VPV
Q
HP
M
Y
I
D
G
QFVTWRGD
---
AWIDVV
NPAT
EAV
I
SRIPD
G
QAE
D
A
R
K
A
I
D
AA
ERA
Q
--PE
W
EALP
A
IE
R
ASW
L
R
K
IS
A
G
I
R
ERAG
E
I
S
A
L
I
VE
E
G
GK
-IQQLAEV
E
V
AFTADYID
Y
M
A
E
WARRYE
G
EIIQSD
---
--RPGENILLF
K
R
A
LGV
T
T
G
I
L
PWNFP
FF
L
IA
R
K
MA
PAL
LT
GN
T
I
V
I
KPSE
F
TP
N
N
A
I
AF
A
K
I
VD
E
I
G
L
P
R
GV
F
N
L
V
L
G
R
G
ETV
G
QE
L
A
G
N
P
K
V
AM
VS
M
TGS
VS
A
G
E
K
I
MAT
A
-
A
K
NI
T
K
V
C
LELGGK
A
P
A
IV
MD
D
-
AD
-----
L
E
L
A
VKAIVDSRVI
N
S
GQVC
NCAE
RV
YVQKGIY
D
Q
F
VNRLGEAMQAV
Q
F
G
NPAERN
D
IAM
GPL
I
N
A
A
A
L
E
R
V
EQK
V
AR
A
VEE
G
-
AR
V
AL
G
G
--
KAVE
G
--
-
-
K
GY
YYP
PTL
LLDVRQEMS
I
MH
EE
T
FGPVL
P
V
VAFDTL
EEAI
SM
ANDS
D
YGL
T
S
S
L
Y
T
Q
N
L
NV
A
M
K
A
I
KG
LK
F
G
ET
Y
I
N
RENFEAMQG
F
H
A
G
W
R
K
SG
I
G
GAD
G
KHG
L
HE
Y
LQT
Q
V
V
Y
L
fig|585056.7.peg.1857
Escherichia coli UMN026 (1-477/479)
M
S
VPV
Q
HP
M
Y
I
D
G
QFVTWRGD
---
AWIDVV
NPAT
EAV
I
SRIPD
G
QAE
D
A
R
K
A
I
D
AA
ERA
Q
--PE
W
EALP
A
IE
R
ASW
L
R
K
IS
A
G
I
R
ERAG
E
I
S
A
L
I
VE
E
G
GK
-IQQLAEV
E
V
AFTADYID
Y
M
A
E
WARRYE
G
EIIQSD
---
--RPGENILLF
K
R
A
LGV
T
T
G
I
L
PWNFP
FF
L
IA
R
K
MA
PAL
LT
GN
T
I
V
I
KPSE
F
TP
N
N
A
I
AF
A
K
I
VD
E
I
G
L
P
R
GV
F
N
L
V
L
G
R
G
ETV
G
QE
L
A
G
N
P
K
V
AM
VS
M
TGS
VS
A
G
E
K
I
MAT
A
-
A
K
NI
T
K
V
C
LELGGK
A
P
A
IV
MD
D
-
AD
-----
L
E
L
A
VKAIVDSRVI
N
S
GQVC
NCAE
RV
YVQKGIY
D
Q
F
VNRLGEAMQAV
Q
F
G
NPAERN
D
IAM
GPL
I
N
A
A
A
L
E
R
V
EQK
V
AR
A
VEE
G
-
AR
V
AL
G
G
--
KAVE
G
--
-
-
K
GY
YYP
PTL
LLDVRQEMS
I
MH
EE
T
FGPVL
P
V
VAFDTL
EEAI
SM
ANDS
D
YGL
T
S
S
L
Y
T
Q
N
L
NV
A
M
K
A
I
KG
LK
F
G
ET
Y
I
N
RENFEAMQG
F
H
A
G
W
R
K
SG
I
G
GAD
G
KHG
L
HE
Y
LQT
Q
V
V
Y
L
fig|316401.4.peg.1707
Escherichia coli ETEC H10407 (1-477/479)
M
S
VPV
Q
HP
M
Y
I
D
G
QFVTWRGD
---
AWIDVV
NPAT
EAV
I
SRIPD
G
QAE
D
A
R
K
A
I
D
AA
ERA
Q
--PE
W
EALP
A
IE
R
ASW
L
R
K
IS
A
G
I
R
ERAS
E
I
S
A
L
I
VE
E
G
GK
-IQQLAEV
E
V
AFTADYID
Y
M
A
E
WARRYE
G
EIIQSD
---
--RPGENILLF
K
R
A
LGV
T
T
G
I
L
PWNFP
FF
L
IA
R
K
MA
PAL
LT
GN
T
I
V
I
KPSE
F
TP
N
N
A
I
AF
A
K
I
VD
E
I
G
L
P
R
GV
F
N
L
V
L
G
R
G
ETV
G
QE
L
A
G
N
P
K
V
AM
VS
M
TGS
VS
A
G
E
K
I
MAT
A
-
A
K
NI
T
K
V
C
LELGGK
A
P
A
IV
MD
D
-
A
N
-----
L
E
L
A
VKAIVDSRVI
N
S
GQVC
NCAE
R
I
YVQKGIY
D
Q
F
VNRLGEAMQAV
Q
F
G
NPAERN
D
IAM
GPL
I
N
A
A
A
L
E
R
V
EQK
V
AR
A
VEE
G
-
AR
V
AL
G
G
--
KAVE
G
--
-
-
K
GY
YYP
PTL
LLDVRQEMS
I
MH
EE
T
FGPVL
P
V
VAFDTL
EEAI
SM
ANDS
D
YGL
T
S
S
I
Y
T
Q
N
L
NV
A
M
K
A
I
KG
LK
F
G
ET
Y
I
N
RENFEAMQG
F
H
A
G
W
R
K
SG
I
G
GAD
G
KHG
L
HE
Y
LQT
Q
V
V
Y
L
fig|749531.3.peg.370
Escherichia coli MS 69-1 (1-477/479)
M
S
VPV
Q
HP
M
Y
I
D
G
QFVTWRGD
---
AWIDVV
NPAT
EAV
I
SRIPD
G
QAE
D
A
R
K
A
I
D
AA
ERA
Q
--PE
W
EALP
A
IE
R
ASW
L
R
K
IS
V
G
I
R
ERAS
E
I
S
A
L
I
VE
E
G
GK
-IQQLAEV
E
V
AFTADYID
Y
M
A
E
WARRYE
G
EIIQSD
---
--RPGENILLF
K
R
A
LGV
T
T
G
I
L
PWNFP
FF
L
IA
R
K
MA
PAL
LT
GN
T
I
V
I
KPSE
F
TP
N
N
A
I
AF
A
K
I
VD
E
I
G
L
P
R
GV
F
N
L
V
L
G
R
G
ETV
G
QE
L
A
G
N
P
K
V
AM
VS
M
TGS
VS
A
G
E
K
I
MAT
A
-
A
K
NI
T
K
V
C
LELGGK
A
P
A
IV
MD
D
-
AD
-----
L
E
L
A
VKAIVDSRVI
N
S
GQVC
NCAE
RV
YVQKGIY
D
Q
F
VNRLGEALQAV
Q
F
G
NPAERN
D
IAM
GPL
I
N
A
A
A
L
E
R
V
EQK
V
AR
A
VEE
G
-
AR
V
AL
G
G
--
KAVE
G
--
-
-
K
GY
YYP
PTL
LLDVRQEMS
I
MH
EE
T
FGPVL
P
V
VAFDTL
E
D
AI
AM
ANDS
D
YGL
T
S
S
I
Y
T
Q
N
L
NV
A
M
K
A
I
KG
LK
F
G
ET
Y
I
N
RENFEAMQG
F
H
A
G
W
R
K
SG
I
G
GAD
G
KHG
L
HE
Y
LQT
Q
V
V
Y
L
fig|749537.3.peg.132
Escherichia coli MS 115-1 (1-477/479)
M
S
VPV
Q
HP
M
Y
I
D
G
QFVTWRGD
---
AWIDVV
NPAT
EAV
I
SRIPD
G
QAE
D
A
R
K
A
I
D
AA
ERA
Q
--PE
W
EALP
A
IE
R
ASW
L
R
K
IS
A
G
I
R
ERAS
E
I
S
A
L
I
VE
E
G
GK
-IQQLAEV
E
V
AFTADYID
Y
M
A
E
WARRYE
G
EIIQSD
---
--RPGENILLF
K
R
A
LGV
T
T
G
I
L
PWNFP
FF
L
IA
R
K
MA
PAL
LT
GN
T
I
V
I
KPSE
F
TP
N
N
A
I
AF
A
K
I
VD
E
I
G
L
P
R
GV
F
N
L
V
L
G
R
G
ETV
G
QE
L
A
G
N
P
K
V
AM
VS
M
TGS
VS
A
G
E
K
I
MAT
A
-
A
K
NI
T
K
V
C
LELGGK
A
P
A
IV
MD
D
-
AD
-----
L
E
L
A
VKAIVDSRVI
N
S
GQVC
NCAE
RV
YVQKGIY
D
Q
F
VNRLGEAMQAV
Q
F
G
NPAERN
D
IAM
GPL
I
N
A
A
A
L
E
R
V
EQK
V
AR
A
VEE
G
-
AR
V
AL
G
G
--
KAVD
G
--
-
-
K
GY
YYP
PTL
LLDVRQEMS
I
MH
EE
T
FGPVL
P
V
VAFDTL
E
D
AI
SM
ANDS
D
YGL
T
S
S
I
Y
T
Q
N
L
NV
A
M
K
A
I
KG
LK
F
G
ET
Y
I
N
RENFETMQG
F
H
A
G
W
R
K
SG
I
G
GAD
G
KHG
L
HE
Y
LQT
Q
V
V
Y
L
fig|1040638.4.peg.4154
Escherichia coli O104:H4 str. LB226692 (1-477/479)
M
S
VPV
Q
HP
M
Y
I
D
G
QFVTWRGD
---
AWIDVV
NPAT
EAV
I
SRIPD
G
QAE
D
A
R
K
A
I
D
AA
ERA
Q
--PE
W
EALP
A
IE
R
ASW
L
R
K
IS
A
G
I
R
ERAS
E
I
S
A
L
I
VE
E
G
GK
-IQQLAEV
E
V
AFTADYID
Y
M
A
E
WARRYE
G
EIIQSD
---
--RPGENILLF
K
R
A
LGV
T
T
G
I
L
PWNFP
FF
L
IA
R
K
MA
PAL
LT
GN
T
I
V
I
KPSE
F
TP
N
N
A
I
AF
A
K
I
VD
E
I
G
L
P
R
GV
F
N
L
V
L
G
R
G
ETV
G
QE
L
A
G
N
P
K
V
AM
VS
M
TGS
VS
A
G
E
K
I
MAT
A
-
A
K
NI
T
K
V
C
LELGGK
A
P
A
IV
MD
D
-
AD
-----
L
E
L
A
VKAIVDSRVI
N
S
GQVC
NCAE
RV
YVQKGIY
D
Q
F
VNRLGEAMQAV
Q
F
G
NPAERN
D
IAM
GPL
I
N
A
A
A
L
E
R
V
EQK
V
AR
A
VEE
G
-
AR
V
AL
G
G
--
KAVD
G
--
-
-
K
GY
YYP
PTL
LLDVRQEMS
I
MH
EE
T
FGPVL
P
V
VAFDTL
E
D
AI
SM
ANDS
D
YGL
T
S
S
I
Y
T
Q
N
L
NV
A
M
K
A
I
KG
LK
F
G
ET
Y
I
N
RENFEAMQG
F
H
A
G
W
R
K
SG
I
G
GAD
G
KHG
L
HE
Y
LQT
Q
V
V
Y
L
fig|585055.6.peg.1576
Escherichia coli 55989 (1-477/479)
M
S
VPV
Q
HP
M
Y
I
D
G
QFVTWRGD
---
AWIDVV
NPAT
EAV
I
SRIPD
G
QAE
D
A
R
K
A
I
D
AA
ERA
Q
--PE
W
EALP
A
IE
R
ASW
L
R
K
IS
A
G
I
R
ERAS
E
I
S
A
L
I
VE
E
G
GK
-IQQLAEV
E
V
AFTADYID
Y
M
A
E
WARRYE
G
EIIQSD
---
--RPGENILLF
K
R
A
LGV
T
T
G
I
L
PWNFP
FF
L
IA
R
K
MA
PAL
LT
GN
T
I
V
I
KPSE
F
TP
N
N
A
I
AF
A
K
I
VD
E
I
G
L
P
R
GV
F
N
L
V
L
G
R
G
ETV
G
QE
L
A
G
N
P
K
V
AM
VS
M
TGS
VS
A
G
E
K
I
MAT
A
-
A
K
NI
T
K
V
C
LELGGK
A
P
A
IV
MD
D
-
AD
-----
L
E
L
A
VKAIVDSRVI
N
S
GQVC
NCAE
RV
YVQKGIY
D
Q
F
VNRLGEAMQAV
Q
F
G
NPAERN
D
IAM
GPL
I
N
A
A
A
L
E
R
V
EQK
V
AR
A
VEE
G
-
AR
V
AL
G
G
--
KAVD
G
--
-
-
K
GY
YYP
PTL
LLDVRQEMS
I
MH
EE
T
FGPVL
P
V
VAFDTL
E
D
AI
SM
ANDS
D
YGL
T
S
S
I
Y
T
Q
N
L
NV
A
M
K
A
I
KG
LK
F
G
ET
Y
I
N
RENFEAMQG
F
H
A
G
W
R
K
SG
I
G
GAD
G
KHG
L
HE
Y
LQT
Q
V
V
Y
L
fig|585055.8.peg.1578
Escherichia coli 55989 (1-477/479)
M
S
VPV
Q
HP
M
Y
I
D
G
QFVTWRGD
---
AWIDVV
NPAT
EAV
I
SRIPD
G
QAE
D
A
R
K
A
I
D
AA
ERA
Q
--PE
W
EALP
A
IE
R
ASW
L
R
K
IS
A
G
I
R
ERAS
E
I
S
A
L
I
VE
E
G
GK
-IQQLAEV
E
V
AFTADYID
Y
M
A
E
WARRYE
G
EIIQSD
---
--RPGENILLF
K
R
A
LGV
T
T
G
I
L
PWNFP
FF
L
IA
R
K
MA
PAL
LT
GN
T
I
V
I
KPSE
F
TP
N
N
A
I
AF
A
K
I
VD
E
I
G
L
P
R
GV
F
N
L
V
L
G
R
G
ETV
G
QE
L
A
G
N
P
K
V
AM
VS
M
TGS
VS
A
G
E
K
I
MAT
A
-
A
K
NI
T
K
V
C
LELGGK
A
P
A
IV
MD
D
-
AD
-----
L
E
L
A
VKAIVDSRVI
N
S
GQVC
NCAE
RV
YVQKGIY
D
Q
F
VNRLGEAMQAV
Q
F
G
NPAERN
D
IAM
GPL
I
N
A
A
A
L
E
R
V
EQK
V
AR
A
VEE
G
-
AR
V
AL
G
G
--
KAVD
G
--
-
-
K
GY
YYP
PTL
LLDVRQEMS
I
MH
EE
T
FGPVL
P
V
VAFDTL
E
D
AI
SM
ANDS
D
YGL
T
S
S
I
Y
T
Q
N
L
NV
A
M
K
A
I
KG
LK
F
G
ET
Y
I
N
RENFEAMQG
F
H
A
G
W
R
K
SG
I
G
GAD
G
KHG
L
HE
Y
LQT
Q
V
V
Y
L
fig|595495.4.peg.933
Escherichia coli KO11 (1-477/479)
M
S
VPV
Q
HP
M
Y
I
D
G
QFVTWRGD
---
AWIDVV
NPAT
EAV
I
SRIPD
G
QAE
D
A
R
K
A
I
D
AA
ERA
Q
--PE
W
EALP
A
IE
R
ASW
L
R
K
IS
A
G
I
R
ERAS
E
I
S
A
L
I
VE
E
G
GK
-IQQLAEV
E
V
AFTADYID
Y
M
A
E
WARRYE
G
EIIQSD
---
--RPGENILLF
K
R
A
LGV
T
T
G
I
L
PWNFP
FF
L
IA
R
K
MA
PAL
LT
GN
T
I
V
I
KPSE
F
TP
N
N
A
I
AF
A
K
I
VD
E
I
G
L
P
R
GV
F
N
L
V
L
G
R
G
ETV
G
QE
L
A
G
N
P
K
V
AM
VS
M
TGS
VS
A
G
E
K
I
MAT
A
-
A
K
NI
T
K
V
C
LELGGK
A
P
A
IV
MD
D
-
AD
-----
L
E
L
A
VKAIVDSRVI
N
S
GQVC
NCAE
RV
YVQKGIY
D
Q
F
VNRLGEAMQAV
Q
F
G
NPAERN
D
IAM
GPL
I
N
A
A
A
L
E
R
V
EQK
V
AR
A
VEE
G
-
AR
V
AL
G
G
--
KAVD
G
--
-
-
K
GY
YYP
PTL
LLDVRQEMS
I
MH
EE
T
FGPVL
P
V
VAFDTL
E
D
AI
SM
ANDS
D
YGL
T
S
S
I
Y
T
Q
N
L
NV
A
M
K
A
I
KG
LK
F
G
ET
Y
I
N
RENFEAMQG
F
H
A
G
W
R
K
SG
I
G
GAD
G
KHG
L
HE
Y
LQT
Q
V
V
Y
L
fig|679205.4.peg.3405
Escherichia coli MS 124-1 (1-477/479)
M
S
VPV
Q
HP
M
Y
I
D
G
QFVTWRGD
---
AWIDVV
NPAT
EAV
I
SRIPD
G
QAE
D
A
R
K
A
I
D
AA
ERA
Q
--PE
W
EALP
A
IE
R
ASW
L
R
K
IS
A
G
I
R
ERAS
E
I
S
A
L
I
VE
E
G
GK
-IQQLAEV
E
V
AFTADYID
Y
M
A
E
WARRYE
G
EIIQSD
---
--RPGENILLF
K
R
A
LGV
T
T
G
I
L
PWNFP
FF
L
IA
R
K
MA
PAL
LT
GN
T
I
V
I
KPSE
F
TP
N
N
A
I
AF
A
K
I
VD
E
I
G
L
P
R
GV
F
N
L
V
L
G
R
G
ETV
G
QE
L
A
G
N
P
K
V
AM
VS
M
TGS
VS
A
G
E
K
I
MAT
A
-
A
K
NI
T
K
V
C
LELGGK
A
P
A
IV
MD
D
-
AD
-----
L
E
L
A
VKAIVDSRVI
N
S
GQVC
NCAE
RV
YVQKGIY
D
Q
F
VNRLGEAMQAV
Q
F
G
NPAERN
D
IAM
GPL
I
N
A
A
A
L
E
R
V
EQK
V
AR
A
VEE
G
-
AR
V
AL
G
G
--
KAVD
G
--
-
-
K
GY
YYP
PTL
LLDVRQEMS
I
MH
EE
T
FGPVL
P
V
VAFDTL
E
D
AI
SM
ANDS
D
YGL
T
S
S
I
Y
T
Q
N
L
NV
A
M
K
A
I
KG
LK
F
G
ET
Y
I
N
RENFEAMQG
F
H
A
G
W
R
K
SG
I
G
GAD
G
KHG
L
HE
Y
LQT
Q
V
V
Y
L
fig|749533.3.peg.41
Escherichia coli MS 84-1 (1-477/479)
M
S
VPV
Q
HP
M
Y
I
D
G
QFVTWRGD
---
AWIDVV
NPAT
EAV
I
SRIPD
G
QAE
D
A
R
K
A
I
D
AA
ERA
Q
--PE
W
EALP
A
IE
R
ASW
L
R
K
IS
A
G
I
R
ERAS
E
I
S
A
L
I
VE
E
G
GK
-IQQLAEV
E
V
AFTADYID
Y
M
A
E
WARRYE
G
EIIQSD
---
--RPGENILLF
K
R
A
LGV
T
T
G
I
L
PWNFP
FF
L
IA
R
K
MA
PAL
LT
GN
T
I
V
I
KPSE
F
TP
N
N
A
I
AF
A
K
I
VD
E
I
G
L
P
R
GV
F
N
L
V
L
G
R
G
ETV
G
QE
L
A
G
N
P
K
V
AM
VS
M
TGS
VS
A
G
E
K
I
MAT
A
-
A
K
NI
T
K
V
C
LELGGK
A
P
A
IV
MD
D
-
AD
-----
L
E
L
A
VKAIVDSRVI
N
S
GQVC
NCAE
RV
YVQKGIY
D
Q
F
VNRLGEAMQAV
Q
F
G
NPAERN
D
IAM
GPL
I
N
A
A
A
L
E
R
V
EQK
V
AR
A
VEE
G
-
AR
V
AL
G
G
--
KAVD
G
--
-
-
K
GY
YYP
PTL
LLDVRQEMS
I
MH
EE
T
FGPVL
P
V
VAFDTL
E
D
AI
SM
ANDS
D
YGL
T
S
S
I
Y
T
Q
N
L
NV
A
M
K
A
I
KG
LK
F
G
ET
Y
I
N
RENFEAMQG
F
H
A
G
W
R
K
SG
I
G
GAD
G
KHG
L
HE
Y
LQT
Q
V
V
Y
L
fig|566546.3.peg.50
Escherichia coli W (1-477/479)
M
S
VPV
Q
HP
M
Y
I
D
G
QFVTWRGD
---
AWIDVV
NPAT
EAV
I
SRIPD
G
QAE
D
A
R
K
A
I
D
AA
ERA
Q
--PE
W
EALP
A
IE
R
ASW
L
R
K
IS
A
G
I
R
ERAS
E
I
S
A
L
I
VE
E
G
GK
-IQQLAEV
E
V
AFTADYID
Y
M
A
E
WARRYE
G
EIIQSD
---
--RPGENILLF
K
R
A
LGV
T
T
G
I
L
PWNFP
FF
L
IA
R
K
MA
PAL
LT
GN
T
I
V
I
KPSE
F
TP
N
N
A
I
AF
A
K
I
VD
E
I
G
L
P
R
GV
F
N
L
V
L
G
R
G
ETV
G
QE
L
A
G
N
P
K
V
AM
VS
M
TGS
VS
A
G
E
K
I
MAT
A
-
A
K
NI
T
K
V
C
LELGGK
A
P
A
IV
MD
D
-
AD
-----
L
E
L
A
VKAIVDSRVI
N
S
GQVC
NCAE
RV
YVQKGIY
D
Q
F
VNRLGEAMQAV
Q
F
G
NPAERN
D
IAM
GPL
I
N
A
A
A
L
E
R
V
EQK
V
AR
A
VEE
G
-
AR
V
AL
G
G
--
KAVD
G
--
-
-
K
GY
YYP
PTL
LLDVRQEMS
I
MH
EE
T
FGPVL
P
V
VAFDTL
E
D
AI
SM
ANDS
D
YGL
T
S
S
I
Y
T
Q
N
L
NV
A
M
K
A
I
KG
LK
F
G
ET
Y
I
N
RENFEAMQG
F
H
A
G
W
R
K
SG
I
G
GAD
G
KHG
L
HE
Y
LQT
Q
V
V
Y
L
fig|566546.4.peg.1531
Escherichia coli W (1-477/479)
M
S
VPV
Q
HP
M
Y
I
D
G
QFVTWRGD
---
AWIDVV
NPAT
EAV
I
SRIPD
G
QAE
D
A
R
K
A
I
D
AA
ERA
Q
--PE
W
EALP
A
IE
R
ASW
L
R
K
IS
A
G
I
R
ERAS
E
I
S
A
L
I
VE
E
G
GK
-IQQLAEV
E
V
AFTADYID
Y
M
A
E
WARRYE
G
EIIQSD
---
--RPGENILLF
K
R
A
LGV
T
T
G
I
L
PWNFP
FF
L
IA
R
K
MA
PAL
LT
GN
T
I
V
I
KPSE
F
TP
N
N
A
I
AF
A
K
I
VD
E
I
G
L
P
R
GV
F
N
L
V
L
G
R
G
ETV
G
QE
L
A
G
N
P
K
V
AM
VS
M
TGS
VS
A
G
E
K
I
MAT
A
-
A
K
NI
T
K
V
C
LELGGK
A
P
A
IV
MD
D
-
AD
-----
L
E
L
A
VKAIVDSRVI
N
S
GQVC
NCAE
RV
YVQKGIY
D
Q
F
VNRLGEAMQAV
Q
F
G
NPAERN
D
IAM
GPL
I
N
A
A
A
L
E
R
V
EQK
V
AR
A
VEE
G
-
AR
V
AL
G
G
--
KAVD
G
--
-
-
K
GY
YYP
PTL
LLDVRQEMS
I
MH
EE
T
FGPVL
P
V
VAFDTL
E
D
AI
SM
ANDS
D
YGL
T
S
S
I
Y
T
Q
N
L
NV
A
M
K
A
I
KG
LK
F
G
ET
Y
I
N
RENFEAMQG
F
H
A
G
W
R
K
SG
I
G
GAD
G
KHG
L
HE
Y
LQT
Q
V
V
Y
L
fig|595496.3.peg.1367
Escherichia coli BW2952 (1-477/479)
M
S
VPV
Q
HP
M
Y
I
D
G
QFVTWRGD
---
AWIDVV
NPAT
EAV
I
SRIPD
G
QAE
D
A
R
K
A
I
D
AA
ERA
Q
--PE
W
EALP
A
IE
R
ASW
L
R
K
IS
A
G
I
R
ERAS
E
I
S
A
L
I
VE
E
G
GK
-IQQLAEV
E
V
AFTADYID
Y
M
A
E
WARRYE
G
EIIQSD
---
--RPGENILLF
K
R
A
LGV
T
T
G
I
L
PWNFP
FF
L
IA
R
K
MA
PAL
LT
GN
T
I
V
I
KPSE
F
TP
N
N
A
I
AF
A
K
I
VD
E
I
G
L
P
R
GV
F
N
L
V
L
G
R
G
ETV
G
QE
L
A
G
N
P
K
V
AM
VS
M
TGS
VS
A
G
E
K
I
MAT
A
-
A
K
NI
T
K
V
C
LELGGK
A
P
A
IV
MD
D
-
AD
-----
L
E
L
A
VKAIVDSRVI
N
S
GQVC
NCAE
RV
YVQKGIY
D
Q
F
VNRLGEAMQAV
Q
F
G
NPAERN
D
IAM
GPL
I
N
A
A
A
L
E
R
V
EQK
V
AR
A
VEE
G
-
AR
V
AF
G
G
--
KAVE
G
--
-
-
K
GY
YYP
PTL
LLDVRQEMS
I
MH
EE
T
FGPVL
P
V
VAFDTL
E
D
AI
SM
ANDS
D
YGL
T
S
S
I
Y
T
Q
N
L
NV
A
M
K
A
I
KG
LK
F
G
ET
Y
I
N
RENFEAMQG
F
H
A
G
W
R
K
SG
I
G
GAD
G
KHG
L
HE
Y
LQT
Q
V
V
Y
L
fig|536056.3.peg.2343
Escherichia coli DH1 (1-477/479)
M
S
VPV
Q
HP
M
Y
I
D
G
QFVTWRGD
---
AWIDVV
NPAT
EAV
I
SRIPD
G
QAE
D
A
R
K
A
I
D
AA
ERA
Q
--PE
W
EALP
A
IE
R
ASW
L
R
K
IS
A
G
I
R
ERAS
E
I
S
A
L
I
VE
E
G
GK
-IQQLAEV
E
V
AFTADYID
Y
M
A
E
WARRYE
G
EIIQSD
---
--RPGENILLF
K
R
A
LGV
T
T
G
I
L
PWNFP
FF
L
IA
R
K
MA
PAL
LT
GN
T
I
V
I
KPSE
F
TP
N
N
A
I
AF
A
K
I
VD
E
I
G
L
P
R
GV
F
N
L
V
L
G
R
G
ETV
G
QE
L
A
G
N
P
K
V
AM
VS
M
TGS
VS
A
G
E
K
I
MAT
A
-
A
K
NI
T
K
V
C
LELGGK
A
P
A
IV
MD
D
-
AD
-----
L
E
L
A
VKAIVDSRVI
N
S
GQVC
NCAE
RV
YVQKGIY
D
Q
F
VNRLGEAMQAV
Q
F
G
NPAERN
D
IAM
GPL
I
N
A
A
A
L
E
R
V
EQK
V
AR
A
VEE
G
-
AR
V
AF
G
G
--
KAVE
G
--
-
-
K
GY
YYP
PTL
LLDVRQEMS
I
MH
EE
T
FGPVL
P
V
VAFDTL
E
D
AI
SM
ANDS
D
YGL
T
S
S
I
Y
T
Q
N
L
NV
A
M
K
A
I
KG
LK
F
G
ET
Y
I
N
RENFEAMQG
F
H
A
G
W
R
K
SG
I
G
GAD
G
KHG
L
HE
Y
LQT
Q
V
V
Y
L
fig|83333.1.peg.1403
Escherichia coli K12 (1-477/479)
M
S
VPV
Q
HP
M
Y
I
D
G
QFVTWRGD
---
AWIDVV
NPAT
EAV
I
SRIPD
G
QAE
D
A
R
K
A
I
D
AA
ERA
Q
--PE
W
EALP
A
IE
R
ASW
L
R
K
IS
A
G
I
R
ERAS
E
I
S
A
L
I
VE
E
G
GK
-IQQLAEV
E
V
AFTADYID
Y
M
A
E
WARRYE
G
EIIQSD
---
--RPGENILLF
K
R
A
LGV
T
T
G
I
L
PWNFP
FF
L
IA
R
K
MA
PAL
LT
GN
T
I
V
I
KPSE
F
TP
N
N
A
I
AF
A
K
I
VD
E
I
G
L
P
R
GV
F
N
L
V
L
G
R
G
ETV
G
QE
L
A
G
N
P
K
V
AM
VS
M
TGS
VS
A
G
E
K
I
MAT
A
-
A
K
NI
T
K
V
C
LELGGK
A
P
A
IV
MD
D
-
AD
-----
L
E
L
A
VKAIVDSRVI
N
S
GQVC
NCAE
RV
YVQKGIY
D
Q
F
VNRLGEAMQAV
Q
F
G
NPAERN
D
IAM
GPL
I
N
A
A
A
L
E
R
V
EQK
V
AR
A
VEE
G
-
AR
V
AF
G
G
--
KAVE
G
--
-
-
K
GY
YYP
PTL
LLDVRQEMS
I
MH
EE
T
FGPVL
P
V
VAFDTL
E
D
AI
SM
ANDS
D
YGL
T
S
S
I
Y
T
Q
N
L
NV
A
M
K
A
I
KG
LK
F
G
ET
Y
I
N
RENFEAMQG
F
H
A
G
W
R
K
SG
I
G
GAD
G
KHG
L
HE
Y
LQT
Q
V
V
Y
L
fig|749538.3.peg.3483
Escherichia coli MS 116-1 (1-477/479)
M
S
VPV
Q
HP
M
Y
I
D
G
QFVTWRGD
---
AWIDVV
NPAT
EAV
I
SRIPD
G
QAE
D
A
R
K
A
I
D
AA
ERA
Q
--PE
W
EALP
A
IE
R
ASW
L
R
K
IS
A
G
I
R
ERAS
E
I
S
A
L
I
VE
E
G
GK
-IQQLAEV
E
V
AFTADYID
Y
M
A
E
WARRYE
G
EIIQSD
---
--RPGENILLF
K
R
A
LGV
T
T
G
I
L
PWNFP
FF
L
IA
R
K
MA
PAL
LT
GN
T
I
V
I
KPSE
F
TP
N
N
A
I
AF
A
K
I
VD
E
I
G
L
P
R
GV
F
N
L
V
L
G
R
G
ETV
G
QE
L
A
G
N
P
K
V
AM
VS
M
TGS
VS
A
G
E
K
I
MAT
A
-
A
K
NI
T
K
V
C
LELGGK
A
P
A
IV
MD
D
-
AD
-----
L
E
L
A
VKAIVDSRVI
N
S
GQVC
NCAE
RV
YVQKGIY
D
Q
F
VNRLGEAMQAV
Q
F
G
NPAERN
D
IAM
GPL
I
N
A
A
A
L
E
R
V
EQK
V
AR
A
VEE
G
-
AR
V
AF
G
G
--
KAVE
G
--
-
-
K
GY
YYP
PTL
LLDVRQEMS
I
MH
EE
T
FGPVL
P
V
VAFDTL
E
D
AI
SM
ANDS
D
YGL
T
S
S
I
Y
T
Q
N
L
NV
A
M
K
A
I
KG
LK
F
G
ET
Y
I
N
RENFEAMQG
F
H
A
G
W
R
K
SG
I
G
GAD
G
KHG
L
HE
Y
LQT
Q
V
V
Y
L
fig|749544.3.peg.30
Escherichia coli MS 175-1 (1-477/479)
M
S
VPV
Q
HP
M
Y
I
D
G
QFVTWRGD
---
AWIDVV
NPAT
EAV
I
SRIPD
G
QAE
D
A
R
K
A
I
D
AA
ERA
Q
--PE
W
EALP
A
IE
R
ASW
L
R
K
IS
A
G
I
R
ERAS
E
I
S
A
L
I
VE
E
G
GK
-IQQLAEV
E
V
AFTADYID
Y
M
A
E
WARRYE
G
EIIQSD
---
--RPGENILLF
K
R
A
LGV
T
T
G
I
L
PWNFP
FF
L
IA
R
K
MA
PAL
LT
GN
T
I
V
I
KPSE
F
TP
N
N
A
I
AF
A
K
I
VD
E
I
G
L
P
R
GV
F
N
L
V
L
G
R
G
ETV
G
QE
L
A
G
N
P
K
V
AM
VS
M
TGS
VS
A
G
E
K
I
MAT
A
-
A
K
NI
T
K
V
C
LELGGK
A
P
A
IV
MD
D
-
AD
-----
L
E
L
A
VKAIVDSRVI
N
S
GQVC
NCAE
RV
YVQKGIY
D
Q
F
VNRLGEAMQAV
Q
F
G
NPAERN
D
IAM
GPL
I
N
A
A
A
L
E
R
V
EQK
V
AR
A
VEE
G
-
AR
V
AF
G
G
--
KAVE
G
--
-
-
K
GY
YYP
PTL
LLDVRQEMS
I
MH
EE
T
FGPVL
P
V
VAFDTL
E
D
AI
SM
ANDS
D
YGL
T
S
S
I
Y
T
Q
N
L
NV
A
M
K
A
I
KG
LK
F
G
ET
Y
I
N
RENFEAMQG
F
H
A
G
W
R
K
SG
I
G
GAD
G
KHG
L
HE
Y
LQT
Q
V
V
Y
L
fig|749548.3.peg.48
Escherichia coli MS 196-1 (1-477/479)
M
S
VPV
Q
HP
M
Y
I
D
G
QFVTWRGD
---
AWIDVV
NPAT
EAV
I
SRIPD
G
QAE
D
A
R
K
A
I
D
AA
ERA
Q
--PE
W
EALP
A
IE
R
ASW
L
R
K
IS
A
G
I
R
ERAS
E
I
S
A
L
I
VE
E
G
GK
-IQQLAEV
E
V
AFTADYID
Y
M
A
E
WARRYE
G
EIIQSD
---
--RPGENILLF
K
R
A
LGV
T
T
G
I
L
PWNFP
FF
L
IA
R
K
MA
PAL
LT
GN
T
I
V
I
KPSE
F
TP
N
N
A
I
AF
A
K
I
VD
E
I
G
L
P
R
GV
F
N
L
V
L
G
R
G
ETV
G
QE
L
A
G
N
P
K
V
AM
VS
M
TGS
VS
A
G
E
K
I
MAT
A
-
A
K
NI
T
K
V
C
LELGGK
A
P
A
IV
MD
D
-
AD
-----
L
E
L
A
VKAIVDSRVI
N
S
GQVC
NCAE
RV
YVQKGIY
D
Q
F
VNRLGEAMQAV
Q
F
G
NPAERN
D
IAM
GPL
I
N
A
A
A
L
E
R
V
EQK
V
AR
A
VEE
G
-
AR
V
AF
G
G
--
KAVE
G
--
-
-
K
GY
YYP
PTL
LLDVRQEMS
I
MH
EE
T
FGPVL
P
V
VAFDTL
E
D
AI
SM
ANDS
D
YGL
T
S
S
I
Y
T
Q
N
L
NV
A
M
K
A
I
KG
LK
F
G
ET
Y
I
N
RENFEAMQG
F
H
A
G
W
R
K
SG
I
G
GAD
G
KHG
L
HE
Y
LQT
Q
V
V
Y
L
fig|316407.3.peg.1376
Escherichia coli W3110 (1-477/479)
M
S
VPV
Q
HP
M
Y
I
D
G
QFVTWRGD
---
AWIDVV
NPAT
EAV
I
SRIPD
G
QAE
D
A
R
K
A
I
D
AA
ERA
Q
--PE
W
EALP
A
IE
R
ASW
L
R
K
IS
A
G
I
R
ERAS
E
I
S
A
L
I
VE
E
G
GK
-IQQLAEV
E
V
AFTADYID
Y
M
A
E
WARRYE
G
EIIQSD
---
--RPGENILLF
K
R
A
LGV
T
T
G
I
L
PWNFP
FF
L
IA
R
K
MA
PAL
LT
GN
T
I
V
I
KPSE
F
TP
N
N
A
I
AF
A
K
I
VD
E
I
G
L
P
R
GV
F
N
L
V
L
G
R
G
ETV
G
QE
L
A
G
N
P
K
V
AM
VS
M
TGS
VS
A
G
E
K
I
MAT
A
-
A
K
NI
T
K
V
C
LELGGK
A
P
A
IV
MD
D
-
AD
-----
L
E
L
A
VKAIVDSRVI
N
S
GQVC
NCAE
RV
YVQKGIY
D
Q
F
VNRLGEAMQAV
Q
F
G
NPAERN
D
IAM
GPL
I
N
A
A
A
L
E
R
V
EQK
V
AR
A
VEE
G
-
AR
V
AF
G
G
--
KAVE
G
--
-
-
K
GY
YYP
PTL
LLDVRQEMS
I
MH
EE
T
FGPVL
P
V
VAFDTL
E
D
AI
SM
ANDS
D
YGL
T
S
S
I
Y
T
Q
N
L
NV
A
M
K
A
I
KG
LK
F
G
ET
Y
I
N
RENFEAMQG
F
H
A
G
W
R
K
SG
I
G
GAD
G
KHG
L
HE
Y
LQT
Q
V
V
Y
L
fig|316385.7.peg.1566
Escherichia coli str. K-12 substr. DH10B (1-477/479)
M
S
VPV
Q
HP
M
Y
I
D
G
QFVTWRGD
---
AWIDVV
NPAT
EAV
I
SRIPD
G
QAE
D
A
R
K
A
I
D
AA
ERA
Q
--PE
W
EALP
A
IE
R
ASW
L
R
K
IS
A
G
I
R
ERAS
E
I
S
A
L
I
VE
E
G
GK
-IQQLAEV
E
V
AFTADYID
Y
M
A
E
WARRYE
G
EIIQSD
---
--RPGENILLF
K
R
A
LGV
T
T
G
I
L
PWNFP
FF
L
IA
R
K
MA
PAL
LT
GN
T
I
V
I
KPSE
F
TP
N
N
A
I
AF
A
K
I
VD
E
I
G
L
P
R
GV
F
N
L
V
L
G
R
G
ETV
G
QE
L
A
G
N
P
K
V
AM
VS
M
TGS
VS
A
G
E
K
I
MAT
A
-
A
K
NI
T
K
V
C
LELGGK
A
P
A
IV
MD
D
-
AD
-----
L
E
L
A
VKAIVDSRVI
N
S
GQVC
NCAE
RV
YVQKGIY
D
Q
F
VNRLGEAMQAV
Q
F
G
NPAERN
D
IAM
GPL
I
N
A
A
A
L
E
R
V
EQK
V
AR
A
VEE
G
-
AR
V
AF
G
G
--
KAVE
G
--
-
-
K
GY
YYP
PTL
LLDVRQEMS
I
MH
EE
T
FGPVL
P
V
VAFDTL
E
D
AI
SM
ANDS
D
YGL
T
S
S
I
Y
T
Q
N
L
NV
A
M
K
A
I
KG
LK
F
G
ET
Y
I
N
RENFEAMQG
F
H
A
G
W
R
K
SG
I
G
GAD
G
KHG
L
HE
Y
LQT
Q
V
V
Y
L
fig|511145.12.peg.1478
Escherichia coli str. K-12 substr. MG1655 (1-477/479)
M
S
VPV
Q
HP
M
Y
I
D
G
QFVTWRGD
---
AWIDVV
NPAT
EAV
I
SRIPD
G
QAE
D
A
R
K
A
I
D
AA
ERA
Q
--PE
W
EALP
A
IE
R
ASW
L
R
K
IS
A
G
I
R
ERAS
E
I
S
A
L
I
VE
E
G
GK
-IQQLAEV
E
V
AFTADYID
Y
M
A
E
WARRYE
G
EIIQSD
---
--RPGENILLF
K
R
A
LGV
T
T
G
I
L
PWNFP
FF
L
IA
R
K
MA
PAL
LT
GN
T
I
V
I
KPSE
F
TP
N
N
A
I
AF
A
K
I
VD
E
I
G
L
P
R
GV
F
N
L
V
L
G
R
G
ETV
G
QE
L
A
G
N
P
K
V
AM
VS
M
TGS
VS
A
G
E
K
I
MAT
A
-
A
K
NI
T
K
V
C
LELGGK
A
P
A
IV
MD
D
-
AD
-----
L
E
L
A
VKAIVDSRVI
N
S
GQVC
NCAE
RV
YVQKGIY
D
Q
F
VNRLGEAMQAV
Q
F
G
NPAERN
D
IAM
GPL
I
N
A
A
A
L
E
R
V
EQK
V
AR
A
VEE
G
-
AR
V
AF
G
G
--
KAVE
G
--
-
-
K
GY
YYP
PTL
LLDVRQEMS
I
MH
EE
T
FGPVL
P
V
VAFDTL
E
D
AI
SM
ANDS
D
YGL
T
S
S
I
Y
T
Q
N
L
NV
A
M
K
A
I
KG
LK
F
G
ET
Y
I
N
RENFEAMQG
F
H
A
G
W
R
K
SG
I
G
GAD
G
KHG
L
HE
Y
LQT
Q
V
V
Y
L
fig|511145.6.peg.1465
Escherichia coli str. K-12 substr. MG1655 (1-477/479)
M
S
VPV
Q
HP
M
Y
I
D
G
QFVTWRGD
---
AWIDVV
NPAT
EAV
I
SRIPD
G
QAE
D
A
R
K
A
I
D
AA
ERA
Q
--PE
W
EALP
A
IE
R
ASW
L
R
K
IS
A
G
I
R
ERAS
E
I
S
A
L
I
VE
E
G
GK
-IQQLAEV
E
V
AFTADYID
Y
M
A
E
WARRYE
G
EIIQSD
---
--RPGENILLF
K
R
A
LGV
T
T
G
I
L
PWNFP
FF
L
IA
R
K
MA
PAL
LT
GN
T
I
V
I
KPSE
F
TP
N
N
A
I
AF
A
K
I
VD
E
I
G
L
P
R
GV
F
N
L
V
L
G
R
G
ETV
G
QE
L
A
G
N
P
K
V
AM
VS
M
TGS
VS
A
G
E
K
I
MAT
A
-
A
K
NI
T
K
V
C
LELGGK
A
P
A
IV
MD
D
-
AD
-----
L
E
L
A
VKAIVDSRVI
N
S
GQVC
NCAE
RV
YVQKGIY
D
Q
F
VNRLGEAMQAV
Q
F
G
NPAERN
D
IAM
GPL
I
N
A
A
A
L
E
R
V
EQK
V
AR
A
VEE
G
-
AR
V
AF
G
G
--
KAVE
G
--
-
-
K
GY
YYP
PTL
LLDVRQEMS
I
MH
EE
T
FGPVL
P
V
VAFDTL
E
D
AI
SM
ANDS
D
YGL
T
S
S
I
Y
T
Q
N
L
NV
A
M
K
A
I
KG
LK
F
G
ET
Y
I
N
RENFEAMQG
F
H
A
G
W
R
K
SG
I
G
GAD
G
KHG
L
HE
Y
LQT
Q
V
V
Y
L
fig|670888.3.peg.2081
Escherichia coli 1827-70 (1-477/479)
M
S
VPV
Q
HP
M
Y
I
D
G
QFVTWRGD
---
AWIDVV
NPAT
EAV
I
SRIPD
G
QAE
D
A
R
K
A
I
D
AA
EHA
Q
--PE
W
EALP
A
IE
R
ASW
L
R
K
IS
A
G
I
R
ERAS
E
I
S
A
L
I
VE
E
G
GK
-IQQLAEV
E
V
AFTADYID
Y
M
A
E
WARRYE
G
EIIQSD
---
--RPGENILLF
K
R
A
LGV
T
T
G
I
L
PWNFP
FF
L
IA
R
K
MA
PAL
LT
GN
T
I
V
I
KPSE
F
TP
N
N
A
I
AF
A
K
I
VD
E
I
G
L
P
R
GV
F
N
L
V
L
G
R
G
ETV
G
QE
L
A
G
N
P
K
V
AM
VS
M
TGS
VS
A
G
E
K
I
MAT
A
-
A
K
NI
T
K
V
C
LELGGK
A
P
A
IV
MD
D
-
AD
-----
L
E
L
A
VKAIVDSRVI
N
S
GQVC
NCAE
RV
YVQKGIY
D
Q
F
VNRLGEAMQAV
Q
F
G
NPAERN
D
IAM
GPL
I
N
A
A
A
L
E
R
V
EQK
V
AR
A
VEE
G
-
AR
V
AL
G
G
--
KAVD
G
--
-
-
K
GY
YYP
PTL
LLDVRQEMS
I
MH
EE
T
FGPVL
P
V
VAFDTL
E
D
AI
SM
ANDS
D
YGL
T
S
S
I
Y
T
Q
N
L
NV
A
M
K
A
I
KG
LK
F
G
ET
Y
I
N
RENFEAMQG
F
H
A
G
W
R
K
SG
I
G
GAD
G
KHG
L
HE
Y
LQT
Q
V
V
Y
L
fig|481805.3.peg.2408
Escherichia coli ATCC 8739 (1-477/479)
M
S
VPV
Q
HP
M
Y
I
D
G
QFVTWRGD
---
AWIDVV
NPAT
EAV
I
SRIPD
G
QAE
D
A
R
K
A
I
D
AA
EHA
Q
--PE
W
EALP
A
IE
R
ASW
L
R
K
IS
A
G
I
R
ERAS
E
I
S
A
L
I
VE
E
G
GK
-IQQLAEV
E
V
AFTADYID
Y
M
A
E
WARRYE
G
EIIQSD
---
--RPGENILLF
K
R
A
LGV
T
T
G
I
L
PWNFP
FF
L
IA
R
K
MA
PAL
LT
GN
T
I
V
I
KPSE
F
TP
N
N
A
I
AF
A
K
I
VD
E
I
G
L
P
R
GV
F
N
L
V
L
G
R
G
ETV
G
QE
L
A
G
N
P
K
V
AM
VS
M
TGS
VS
A
G
E
K
I
MAT
A
-
A
K
NI
T
K
V
C
LELGGK
A
P
A
IV
MD
D
-
AD
-----
L
E
L
A
VKAIVDSRVI
N
S
GQVC
NCAE
RV
YVQKGIY
D
Q
F
VNRLGEAMQAV
Q
F
G
NPAERN
D
IAM
GPL
I
N
A
A
A
L
E
R
V
EQK
V
AR
A
VEE
G
-
AR
V
AL
G
G
--
KAVD
G
--
-
-
K
GY
YYP
PTL
LLDVRQEMS
I
MH
EE
T
FGPVL
P
V
VAFDTL
E
D
AI
SM
ANDS
D
YGL
T
S
S
I
Y
T
Q
N
L
NV
A
M
K
A
I
KG
LK
F
G
ET
Y
I
N
RENFEAMQG
F
H
A
G
W
R
K
SG
I
G
GAD
G
KHG
L
HE
Y
LQT
Q
V
V
Y
L
fig|481805.6.peg.2397
Escherichia coli ATCC 8739 (1-477/479)
M
S
VPV
Q
HP
M
Y
I
D
G
QFVTWRGD
---
AWIDVV
NPAT
EAV
I
SRIPD
G
QAE
D
A
R
K
A
I
D
AA
EHA
Q
--PE
W
EALP
A
IE
R
ASW
L
R
K
IS
A
G
I
R
ERAS
E
I
S
A
L
I
VE
E
G
GK
-IQQLAEV
E
V
AFTADYID
Y
M
A
E
WARRYE
G
EIIQSD
---
--RPGENILLF
K
R
A
LGV
T
T
G
I
L
PWNFP
FF
L
IA
R
K
MA
PAL
LT
GN
T
I
V
I
KPSE
F
TP
N
N
A
I
AF
A
K
I
VD
E
I
G
L
P
R
GV
F
N
L
V
L
G
R
G
ETV
G
QE
L
A
G
N
P
K
V
AM
VS
M
TGS
VS
A
G
E
K
I
MAT
A
-
A
K
NI
T
K
V
C
LELGGK
A
P
A
IV
MD
D
-
AD
-----
L
E
L
A
VKAIVDSRVI
N
S
GQVC
NCAE
RV
YVQKGIY
D
Q
F
VNRLGEAMQAV
Q
F
G
NPAERN
D
IAM
GPL
I
N
A
A
A
L
E
R
V
EQK
V
AR
A
VEE
G
-
AR
V
AL
G
G
--
KAVD
G
--
-
-
K
GY
YYP
PTL
LLDVRQEMS
I
MH
EE
T
FGPVL
P
V
VAFDTL
E
D
AI
SM
ANDS
D
YGL
T
S
S
I
Y
T
Q
N
L
NV
A
M
K
A
I
KG
LK
F
G
ET
Y
I
N
RENFEAMQG
F
H
A
G
W
R
K
SG
I
G
GAD
G
KHG
L
HE
Y
LQT
Q
V
V
Y
L
fig|331112.3.peg.1407
Escherichia coli HS (1-477/479)
M
S
VPV
Q
HP
M
Y
I
D
G
QFVTWRGD
---
AWIDVV
NPAT
EAV
I
SRIPD
G
QAE
D
A
R
K
A
I
D
AA
EHA
Q
--PE
W
EALP
A
IE
R
ASW
L
R
K
IS
A
G
I
R
ERAS
E
I
S
A
L
I
VE
E
G
GK
-IQQLAEV
E
V
AFTADYID
Y
M
A
E
WARRYE
G
EIIQSD
---
--RPGENILLF
K
R
A
LGV
T
T
G
I
L
PWNFP
FF
L
IA
R
K
MA
PAL
LT
GN
T
I
V
I
KPSE
F
TP
N
N
A
I
AF
A
K
I
VD
E
I
G
L
P
R
GV
F
N
L
V
L
G
R
G
ETV
G
QE
L
A
G
N
P
K
V
AM
VS
M
TGS
VS
A
G
E
K
I
MAT
A
-
A
K
NI
T
K
V
C
LELGGK
A
P
A
IV
MD
D
-
AD
-----
L
E
L
A
VKAIVDSRVI
N
S
GQVC
NCAE
RV
YVQKGIY
D
Q
F
VNRLGEAMQAV
Q
F
G
NPAERN
D
IAM
GPL
I
N
A
A
A
L
E
R
V
EQK
V
AR
A
VEE
G
-
AR
V
AL
G
G
--
KAVD
G
--
-
-
K
GY
YYP
PTL
LLDVRQEMS
I
MH
EE
T
FGPVL
P
V
VAFDTL
E
D
AI
SM
ANDS
D
YGL
T
S
S
I
Y
T
Q
N
L
NV
A
M
K
A
I
KG
LK
F
G
ET
Y
I
N
RENFEAMQG
F
H
A
G
W
R
K
SG
I
G
GAD
G
KHG
L
HE
Y
LQT
Q
V
V
Y
L
fig|331112.6.peg.1465
Escherichia coli HS (1-477/479)
M
S
VPV
Q
HP
M
Y
I
D
G
QFVTWRGD
---
AWIDVV
NPAT
EAV
I
SRIPD
G
QAE
D
A
R
K
A
I
D
AA
EHA
Q
--PE
W
EALP
A
IE
R
ASW
L
R
K
IS
A
G
I
R
ERAS
E
I
S
A
L
I
VE
E
G
GK
-IQQLAEV
E
V
AFTADYID
Y
M
A
E
WARRYE
G
EIIQSD
---
--RPGENILLF
K
R
A
LGV
T
T
G
I
L
PWNFP
FF
L
IA
R
K
MA
PAL
LT
GN
T
I
V
I
KPSE
F
TP
N
N
A
I
AF
A
K
I
VD
E
I
G
L
P
R
GV
F
N
L
V
L
G
R
G
ETV
G
QE
L
A
G
N
P
K
V
AM
VS
M
TGS
VS
A
G
E
K
I
MAT
A
-
A
K
NI
T
K
V
C
LELGGK
A
P
A
IV
MD
D
-
AD
-----
L
E
L
A
VKAIVDSRVI
N
S
GQVC
NCAE
RV
YVQKGIY
D
Q
F
VNRLGEAMQAV
Q
F
G
NPAERN
D
IAM
GPL
I
N
A
A
A
L
E
R
V
EQK
V
AR
A
VEE
G
-
AR
V
AL
G
G
--
KAVD
G
--
-
-
K
GY
YYP
PTL
LLDVRQEMS
I
MH
EE
T
FGPVL
P
V
VAFDTL
E
D
AI
SM
ANDS
D
YGL
T
S
S
I
Y
T
Q
N
L
NV
A
M
K
A
I
KG
LK
F
G
ET
Y
I
N
RENFEAMQG
F
H
A
G
W
R
K
SG
I
G
GAD
G
KHG
L
HE
Y
LQT
Q
V
V
Y
L
fig|573235.3.peg.2047
Escherichia coli O26:H11 str. 11368 (1-477/479)
M
S
VPV
Q
HP
M
Y
I
D
G
QFVTWRGD
---
AWIDVV
NPA
A
EAV
I
SRIPD
G
QAE
D
A
R
K
A
I
D
AA
ERA
Q
--PE
W
EALP
A
IE
R
ASW
L
R
K
IS
A
G
I
R
ERAS
E
I
S
A
L
I
VE
E
G
GK
-IQQLAEV
E
V
AFTADYID
Y
M
A
E
WARRYE
G
EIIQSD
---
--RPGENILLF
K
R
A
LGV
T
T
G
I
L
PWNFP
FF
L
IA
R
K
MA
PAL
LT
GN
T
I
V
I
KPSE
F
TP
N
N
A
I
AF
A
K
I
VD
E
I
G
L
P
R
GV
F
N
L
V
L
G
R
G
ETV
G
QE
L
A
G
N
P
K
V
AM
VS
M
TGS
VS
A
G
E
K
I
MAT
A
-
A
K
NI
T
K
V
C
LELGGK
A
P
A
IV
MD
D
-
AD
-----
L
E
L
A
VKAIVDSRVI
N
S
GQVC
NCAE
RV
YVQKGIY
D
Q
F
VNRLGEAMQAV
Q
F
G
NPAERN
D
IAM
GPL
I
N
A
A
A
L
E
R
V
EQK
V
AR
A
VEE
G
-
AR
V
AL
G
G
--
KAVD
G
--
-
-
K
GY
YYP
PTL
LLDVRQEMS
I
MH
EE
T
FGPVL
P
V
VAFDTL
E
D
AI
SM
ANDS
D
YGL
T
S
S
I
Y
T
Q
N
L
NV
A
M
K
A
I
KG
LK
F
G
ET
Y
I
N
RENFEAMQG
F
H
A
G
W
R
K
SG
I
G
GAD
G
KHG
L
HE
Y
LQT
Q
V
V
Y
L
fig|550676.3.peg.983
Escherichia coli B185 (1-477/479)
M
S
VPV
Q
HP
M
Y
F
D
G
QFVTWRGD
---
AWIDVV
NPAT
EAV
I
SRIPD
G
QAE
D
A
R
K
A
I
D
AA
ERA
Q
--PE
W
EALP
A
IE
R
ASW
L
R
K
IS
A
G
I
R
ERAS
E
I
S
A
L
I
VE
E
G
GK
-IQQLAEV
E
V
AFTADYID
Y
M
A
E
WARRYE
G
EIIQSD
---
--RPGENILLF
K
R
A
LGV
T
T
G
I
L
PWNFP
FF
L
IA
R
K
MA
PAL
LT
GN
T
I
V
I
KPSE
F
TP
N
N
A
I
AF
A
K
I
VD
E
I
G
L
P
R
GV
F
N
L
V
L
G
R
G
ETV
G
QE
L
A
G
N
P
K
V
AM
VS
M
TGS
VS
A
G
E
K
I
MAT
A
-
A
K
NI
T
K
V
C
LELGGK
A
P
A
IV
MD
D
-
AD
-----
L
E
L
A
VKAIVDSRVI
N
S
GQVC
NCAE
RV
YVQKGIY
D
Q
F
VNRLGEAMQAV
Q
F
G
NPAERN
D
IAM
GPL
I
N
A
A
A
L
E
R
V
EQK
V
AR
A
VEE
G
-
AR
V
AL
G
G
--
KAVE
G
--
-
-
K
GY
YYP
PTL
LLDVRQEMS
I
MH
EE
T
FGPVL
P
V
VAFDTL
E
D
AI
SM
ANDS
D
YG
Q
T
S
S
I
Y
T
Q
N
L
NV
A
M
K
A
I
KG
LK
F
G
ET
Y
I
N
RENFEAMQG
F
H
A
G
W
R
K
SG
I
G
GAD
G
KHG
L
HE
Y
LQT
Q
V
V
Y
L
fig|6666666.5357.peg.3618
Escherichia coli TY-2482 (1-477/479)
M
S
VPV
Q
HP
M
Y
I
D
G
QFVTWRGD
---
AWIDVV
NPAT
EAV
I
SRIPD
G
QAE
D
A
R
K
A
I
D
AA
ERA
Q
--PE
W
EALP
A
IE
R
ASW
L
R
K
IS
A
G
I
R
ERAS
E
I
S
A
L
I
VE
E
G
GK
-IQQLAEV
E
V
AFTADYID
Y
M
A
E
WARRYE
G
EIIQSD
---
--RPGENILLF
K
R
A
LGV
T
T
G
I
L
PWNFP
FF
L
IA
R
K
MA
PAL
LT
GN
T
I
V
I
KPSE
F
TP
N
N
A
I
AF
A
K
I
VD
E
I
G
L
P
R
GV
F
N
L
V
L
G
R
G
ETV
G
QE
L
A
G
N
P
K
V
AM
VS
M
TGS
VS
A
G
E
K
I
MAT
A
-
A
K
NI
T
K
V
C
LELG
V
K
H
P
A
IV
MD
D
-
AD
-----
L
E
L
A
VKAIVDSRVI
N
S
GQVC
NCAE
RV
YVQKGIY
D
Q
F
VNRLGEAMQAV
Q
F
G
NPAERN
D
IAM
GPL
I
N
A
A
A
L
E
R
V
EQK
V
AR
A
VEE
G
-
AR
V
AL
G
G
--
KAVD
G
--
-
-
K
GY
YYP
PTL
LLDVRQEMS
I
MH
EE
T
FGPVL
P
V
VAFDTL
E
D
AI
SM
ANDS
D
YGL
T
S
S
I
Y
T
Q
N
L
NV
A
M
K
A
I
KG
LK
F
G
ET
Y
I
N
RENFEAMQG
F
H
A
G
W
R
K
SG
I
G
GAD
G
KHG
L
HE
Y
LQT
Q
V
V
Y
L
Consen1
Primary consensus
MNFHHlAywqdka
s
q
l
InG
---
nPat
l
a
d
d
Av
aA
f
W
p
R
L
k
d
ie
e
a
Le
d
GK
ei
y
Ag
G
---
r
plGV
a
I
pWNfP
l
wK
PALaaGn
vv
KPSE
tPltal
A
l
eag
P
GV
Nvv
G
G
G
Lt
hp
v
vs
TGs
tGk
i
a
a
nikrv
lElGGKsp
IV
D
-
aD
-----
e
a
n
GQvC
Rv
d
f
q
G
-
gpL
s
ah
d
V
i
a
g
-
v
G
--
G
--
-
gy
PTl
i
eE
FGPVl
v
eeai
ANDsqYGL
a
v
T
dl
A
r
s
Lk
G
wvN
p
gG
k
SG
G
g
L
y
k
v
vsmEA
Consen2
Secondary consensus
v
vlsqvq
f
e
m
d
vn
i
g
q
r
i
s
q
a
r
a
r
v
s
i
dv
e
ipl
k
av
t
a
y
r
lt
c
i
s
n
mi
i
di
-
ll
nn
i
ia
g
e
d
t
t
m
a
a
cp
v
s
d
a
l
d
nt
pa
e
g
qh
l
dg
d
aa
l
k
dqv
t
s
i
nv
i
i
f
a
r
s
i
el
Consensus 1
(when a gap)
Conservative difference
Consensus 2
(when a gap)
Nonconservative diff.
Other character