fig|1040638.4.peg.3965
Escherichia coli O104:H4 str. LB226692
MT
LT
RR
E
F
IK
H
S
G
I
AAG
AL
-
---
-
-
---
-
--
V
V
T
S
AAP
LP
AW
A
E
EK
-
--
G
G
K
I
LTA
G
RWG
A
MNVE
VKD
GK
I
-
---
V
S
STG
A
-
-
-
-
LAKTIPNS
L
QSTAADQVHTTA
RI
Q
HP
MVRKSY
L
D
N
P
LQPAKG
RGE
DTYVQV
SW
EQ
AL
KL
I
HEQ
H
E
RI
R
K
A
N
G
PS
A
I
F
--
-
-
AG
SY
G
WR
S
S
G
V
LHK
A
QT
L
LQ
R
Y
MN
LA
GG
Y
S
GH
S
G
D
YST
GAAQ
V
I
MP
H
VV
GS
VEVYEQQTSW
P
L
IL
ENS
QV
VV
LW
G
M
NP
LN
T
LKIAWSST
V
EQ
GL
E
Y
F-
-
H
QLK
KS
GK
P
V
I
A
IDP
IR
T
E
T
IEFF
G
DNAT
W
IAPNM
GTD
V
AL
ML
GIA
HT
L
M
T
QG
K
H
D
KV
FL
E
KY
TT
GY
PQ
-----
-
--
-
-
-
-
FEE
Y
LT
G
KS
-
D
N
T
P
K
SA
A
WAAEITG
V
P
EA
QI
V
KLA
-
E
LM
AA
NRTMLMA
GWG
I
QRQ
Q
Y
GEQ
K
H
WMLVT
L
AA
ML
G
QI
G
T
P
GG
GF
G
FSYHYSNGGNP
T
R
V
G
GV----
-
-
LP
E
M
S
AAIAG
Q
A
S
-
-
-
--
E
A
A
D
D
G
G-
MTAI
PVARIV
D
ALENPGGKYQHN
GKE
QTYPN
IK
M
IW
-
W
AG
GGN
F
TH
H
Q
D
T
N
R
LIK
A
W
Q
-
-
-
K
P
EMIVV
S
E
C
YW
TA
A
AK
H
ADI
V
LP
ITT
SF
E
RN
DL
T
MTGD
YS
N
Q
-
H
I
V
PM
KQ
A
VA
P
Q
FE
ARNDFD
V
FADL
A
EL
L
K
P
GGKE
I
Y
TEG
K
D
E
MA
WLKF
F
Y
DAAQKG
AR
AQ
R
V
T
MP
M
F
N
A
F
W
QQ
NK
L
IEMR
R
S
E
K
NE
Q
YV
R
Y
A
D
FR
A
DP
V
K
N
A
L
G
TPSGKIEIYS
KT
L
E
K
FGYKDCPAH
P
TW
--
-
---
-
L
A
P
--
-
-
---
-
D
E
W
K
G
T
A
D
E
K
-
Q
LQL
L
TA
H
PA
H
R
L
HS
Q
LNYA
E
L
R
K
K
YAV
A
D
R
EPIT
I
HTE
DA
A
R
F
GIANGD
L
VRV
W
N
K
RG
Q
IL
TG
A
V
VT
DG
I
KK
GV
V
C
V
HE
GAW
P
D
L
E
-
-
-
N
G
L
CKN
GS
A
N
V
LTA
D
I
PS
SQ
LA
NACA
G
N
S
A
LV
Y
IEKYTGNAPKLTAFDQPA
I
QA
fig|6666666.5357.peg.325
Escherichia coli TY-2482
MT
LT
RR
E
F
IK
H
S
G
I
AAG
AL
-
---
-
-
---
-
--
V
V
T
S
AAP
LP
AW
A
E
EK
-
--
G
G
K
I
LTA
G
RWG
A
MNVE
VKD
GK
I
-
---
V
S
STG
A
-
-
-
-
LAKTIPNS
L
QSTAADQVHTTA
RI
Q
HP
MVRKSY
L
D
N
P
LQPAKG
RGE
DTYVQV
SW
EQ
AL
KL
I
HEQ
H
E
RI
R
K
A
N
G
PS
A
I
F
--
-
-
AG
SY
G
WR
S
S
G
V
LHK
A
QT
L
LQ
R
Y
MN
LA
GG
Y
S
GH
S
G
D
YST
GAAQ
V
I
MP
H
VV
GS
VEVYEQQTSW
P
L
IL
ENS
QV
VV
LW
G
M
NP
LN
T
LKIAWSST
V
EQ
GL
E
Y
F-
-
H
QLK
KS
GK
P
V
I
A
IDP
IR
T
E
T
IEFF
G
DNAT
W
IAPNM
GTD
V
AL
ML
GIA
HT
L
M
T
QG
K
H
D
KV
FL
E
KY
TT
GY
PQ
-----
-
--
-
-
-
-
FEE
Y
LT
G
KS
-
D
N
T
P
K
SA
A
WAAEITG
V
P
EA
QI
V
KLA
-
E
LM
AA
NRTMLMA
GWG
I
QRQ
Q
Y
GEQ
K
H
WMLVT
L
AA
ML
G
QI
G
T
P
GG
GF
G
FSYHYSNGGNP
T
R
V
G
GV----
-
-
LP
E
M
S
AAIAG
Q
A
S
-
-
-
--
E
A
A
D
D
G
G-
MTAI
PVARIV
D
ALENPGGKYQHN
GKE
QTYPN
IK
M
IW
-
W
AG
GGN
F
TH
H
Q
D
T
N
R
LIK
A
W
Q
-
-
-
K
P
EMIVV
S
E
C
YW
TA
A
AK
H
ADI
V
LP
ITT
SF
E
RN
DL
T
MTGD
YS
N
Q
-
H
I
V
PM
KQ
A
VA
P
Q
FE
ARNDFD
V
FADL
A
EL
L
K
P
GGKE
I
Y
TEG
K
D
E
MA
WLKF
F
Y
DAAQKG
AR
AQ
R
V
T
MP
M
F
N
A
F
W
QQ
NK
L
IEMR
R
S
E
K
NE
Q
YV
R
Y
A
D
FR
A
DP
V
K
N
A
L
G
TPSGKIEIYS
KT
L
E
K
FGYKDCPAH
P
TW
--
-
---
-
L
A
P
--
-
-
---
-
D
E
W
K
G
T
A
D
E
K
-
Q
LQL
L
TA
H
PA
H
R
L
HS
Q
LNYA
E
L
R
K
K
YAV
A
D
R
EPIT
I
HTE
DA
A
R
F
GIANGD
L
VRV
W
N
K
RG
Q
IL
TG
A
V
VT
DG
I
KK
GV
V
C
V
HE
GAW
P
D
L
E
-
-
-
N
G
L
CKN
GS
A
N
V
LTA
D
I
PS
SQ
LA
NACA
G
N
S
A
LV
Y
IEKYTGNAPKLTAFDQPA
I
QA
fig|585055.6.peg.2081
Escherichia coli 55989
MT
LT
RR
E
F
IK
H
S
G
I
AAG
AL
-
---
-
-
---
-
--
V
V
T
S
AAP
LP
AW
A
E
EK
-
--
G
G
K
I
LTA
G
RWG
A
MNVE
VKD
GK
I
-
---
V
S
STG
A
-
-
-
-
LAKTIPNS
L
QSTAADQVHTTA
RI
Q
HP
MVRKSY
L
D
N
P
LQPAKG
RGE
DTYVQV
SW
EQ
AL
KL
I
HEQ
H
E
RI
R
K
A
N
G
PS
A
I
F
--
-
-
AG
SY
G
WR
S
S
G
V
LHK
A
QT
L
LQ
R
Y
MN
LA
GG
Y
S
GH
S
G
D
YST
GAAQ
V
I
MP
H
VV
GS
VEVYEQQTSW
P
L
IL
ENS
QV
VV
LW
G
M
NP
LN
T
LKIAWSST
V
EQ
GL
E
Y
F-
-
H
QLK
KS
GK
P
V
I
A
IDP
IR
T
E
T
IEFF
G
DNAT
W
IAPNM
GTD
V
AL
ML
GIA
HT
L
M
T
QG
K
H
D
KV
FL
E
KY
TT
GY
PQ
-----
-
--
-
-
-
-
FEE
Y
LT
G
KS
-
D
N
T
P
K
SA
A
WAAEITG
V
P
EA
QI
V
KLA
-
E
LM
AA
NRTMLMA
GWG
I
QRQ
Q
Y
GEQ
K
H
WMLVT
L
AA
ML
G
QI
G
T
P
GG
GF
G
FSYHYSNGGNP
T
R
V
G
GV----
-
-
LP
E
M
S
AAIAG
Q
A
S
-
-
-
--
E
A
A
D
D
G
G-
MTAI
PVARIV
D
ALENPGGKYQHN
GKE
QTYPN
IK
M
IW
-
W
AG
GGN
F
TH
H
Q
D
T
N
R
LIK
A
W
Q
-
-
-
K
P
EMIVV
S
E
C
YW
TA
A
AK
H
ADI
V
LP
ITT
SF
E
RN
DL
T
MTGD
YS
N
Q
-
H
I
V
PM
KQ
A
VA
P
Q
FE
ARNDFD
V
FADL
A
EL
L
K
P
GGKE
I
Y
TEG
K
D
E
MA
WLKF
F
Y
DAAQKG
AR
AQ
R
V
T
MP
M
F
N
A
F
W
QQ
NK
L
IEMR
R
S
E
K
NE
Q
YV
R
Y
A
D
FR
A
DP
V
K
N
A
L
G
TPSGKIEIYS
KT
L
E
K
FGYKDCPAH
P
TW
--
-
---
-
L
A
P
--
-
-
---
-
D
E
W
K
G
T
A
D
E
K
-
Q
LQL
L
TA
H
PA
H
R
L
HS
Q
LNYA
E
L
R
K
K
YAV
A
D
R
EPIT
I
HTE
DA
A
R
F
GIANGD
L
VRV
W
N
K
RG
Q
IL
TG
A
V
VT
DG
I
KK
GV
V
C
V
HE
GAW
P
D
L
E
-
-
-
N
G
L
CKN
GS
A
N
V
LTA
D
I
PS
SQ
LA
NACA
G
N
S
A
LV
Y
IEKYTGNAPKLTAFDQPA
I
QA
fig|585055.8.peg.2084
Escherichia coli 55989
MT
LT
RR
E
F
IK
H
S
G
I
AAG
AL
-
---
-
-
---
-
--
V
V
T
S
AAP
LP
AW
A
E
EK
-
--
G
G
K
I
LTA
G
RWG
A
MNVE
VKD
GK
I
-
---
V
S
STG
A
-
-
-
-
LAKTIPNS
L
QSTAADQVHTTA
RI
Q
HP
MVRKSY
L
D
N
P
LQPAKG
RGE
DTYVQV
SW
EQ
AL
KL
I
HEQ
H
E
RI
R
K
A
N
G
PS
A
I
F
--
-
-
AG
SY
G
WR
S
S
G
V
LHK
A
QT
L
LQ
R
Y
MN
LA
GG
Y
S
GH
S
G
D
YST
GAAQ
V
I
MP
H
VV
GS
VEVYEQQTSW
P
L
IL
ENS
QV
VV
LW
G
M
NP
LN
T
LKIAWSST
V
EQ
GL
E
Y
F-
-
H
QLK
KS
GK
P
V
I
A
IDP
IR
T
E
T
IEFF
G
DNAT
W
IAPNM
GTD
V
AL
ML
GIA
HT
L
M
T
QG
K
H
D
KV
FL
E
KY
TT
GY
PQ
-----
-
--
-
-
-
-
FEE
Y
LT
G
KS
-
D
N
T
P
K
SA
A
WAAEITG
V
P
EA
QI
V
KLA
-
E
LM
AA
NRTMLMA
GWG
I
QRQ
Q
Y
GEQ
K
H
WMLVT
L
AA
ML
G
QI
G
T
P
GG
GF
G
FSYHYSNGGNP
T
R
V
G
GV----
-
-
LP
E
M
S
AAIAG
Q
A
S
-
-
-
--
E
A
A
D
D
G
G-
MTAI
PVARIV
D
ALENPGGKYQHN
GKE
QTYPN
IK
M
IW
-
W
AG
GGN
F
TH
H
Q
D
T
N
R
LIK
A
W
Q
-
-
-
K
P
EMIVV
S
E
C
YW
TA
A
AK
H
ADI
V
LP
ITT
SF
E
RN
DL
T
MTGD
YS
N
Q
-
H
I
V
PM
KQ
A
VA
P
Q
FE
ARNDFD
V
FADL
A
EL
L
K
P
GGKE
I
Y
TEG
K
D
E
MA
WLKF
F
Y
DAAQKG
AR
AQ
R
V
T
MP
M
F
N
A
F
W
QQ
NK
L
IEMR
R
S
E
K
NE
Q
YV
R
Y
A
D
FR
A
DP
V
K
N
A
L
G
TPSGKIEIYS
KT
L
E
K
FGYKDCPAH
P
TW
--
-
---
-
L
A
P
--
-
-
---
-
D
E
W
K
G
T
A
D
E
K
-
Q
LQL
L
TA
H
PA
H
R
L
HS
Q
LNYA
E
L
R
K
K
YAV
A
D
R
EPIT
I
HTE
DA
A
R
F
GIANGD
L
VRV
W
N
K
RG
Q
IL
TG
A
V
VT
DG
I
KK
GV
V
C
V
HE
GAW
P
D
L
E
-
-
-
N
G
L
CKN
GS
A
N
V
LTA
D
I
PS
SQ
LA
NACA
G
N
S
A
LV
Y
IEKYTGNAPKLTAFDQPA
I
QA
fig|670888.3.peg.391
Escherichia coli 1827-70
MT
LT
RR
E
F
IK
H
S
G
I
AAG
AL
-
---
-
-
---
-
--
V
V
T
S
AAP
LP
AW
A
E
EK
-
--
G
G
K
I
LTA
G
RWG
A
MNVE
VKD
GK
I
-
---
V
S
STG
A
-
-
-
-
LAKTIPNS
L
QSTAADQVHTTA
RI
Q
HP
MVRKSY
L
D
N
P
LQPAKG
RGE
DTYVQV
SW
EQ
AL
KL
I
HEQ
H
D
RI
R
K
A
N
G
PS
A
I
F
--
-
-
AG
SY
G
WR
S
S
G
V
LHK
A
QT
L
LQ
R
Y
MN
LA
GG
Y
S
GH
S
G
D
YST
GAAQ
V
I
MP
H
VV
GS
VEVYEQQTSW
P
L
IL
ENS
QV
VV
LW
G
M
NP
LN
T
LKIAWSSTDEQ
GL
E
Y
F-
-
H
QLK
KS
GK
P
V
I
A
IDP
IR
S
E
T
IEFF
G
DNAT
W
IAPNM
GTD
V
AL
ML
GIA
HT
L
M
T
QG
K
H
D
KV
FL
E
KY
TT
GY
PQ
-----
-
--
-
-
-
-
FEE
Y
LT
G
KS
-
D
N
T
P
K
SA
A
WAAEITG
V
P
EA
QI
V
KLA
-
E
LM
AA
NRTMLMA
GWG
I
QRQ
Q
Y
GEQ
K
H
WMLVT
L
AA
ML
G
QI
G
T
P
GG
GF
G
FSYHYSNGGNP
T
R
V
G
GV----
-
-
LP
E
M
S
AAIAG
Q
A
S
-
-
-
--
E
A
A
D
D
G
G-
MTAI
PVARIV
D
ALENPGGKYQHN
GKE
QTYPN
IK
M
IW
-
W
AG
GGN
F
TH
H
Q
D
T
N
R
LIK
A
W
Q
-
-
-
K
P
EMIVV
S
E
C
YW
TA
A
AK
H
ADI
V
LP
ITT
SF
E
RN
DL
T
MTGD
YS
N
Q
-
H
I
V
PM
KQ
A
VA
P
Q
FE
ARNDFD
V
FADL
A
EL
L
K
P
GGKE
I
Y
TEG
K
D
E
MA
WLKF
F
Y
DAAQKG
AR
AQ
R
V
T
MP
M
F
N
A
F
W
QQ
NK
L
IEMR
R
S
E
K
NE
Q
YV
R
Y
G
D
FR
A
DP
V
K
N
A
L
G
TPSGKIEIYS
KT
L
E
K
FGYKDCPAH
P
TW
--
-
---
-
L
A
P
--
-
-
---
-
D
E
W
K
G
T
A
D
E
K
-
Q
LQL
L
TA
H
PA
H
R
L
HS
Q
LNYA
E
L
R
K
K
YAV
A
D
R
EPIT
I
HTE
DA
A
R
F
GIANGD
L
VRV
W
N
K
RG
Q
IL
TG
A
V
VT
DG
I
KK
GV
V
C
V
HE
GAW
P
D
L
E
-
-
-
N
G
L
CKN
GS
A
N
V
LTA
D
I
PS
SQ
LA
NACA
G
N
S
A
LV
Y
IEKYTGNAPKLTAFDQPA
I
QA
fig|481805.3.peg.1897
Escherichia coli ATCC 8739
MT
LT
RR
E
F
IK
H
S
G
I
AAG
AL
-
---
-
-
---
-
--
V
V
T
S
AAP
LP
AW
A
E
EK
-
--
G
G
K
I
LTA
G
RWG
A
MNVE
VKD
GK
I
-
---
V
S
STG
A
-
-
-
-
LAKTIPNS
L
QSTAADQVHTTA
RI
Q
HP
MVRKSY
L
D
N
P
LQPAKG
RGE
DTYVQV
SW
EQ
AL
KL
I
HEQ
H
D
RI
R
K
A
N
G
PS
A
I
F
--
-
-
AG
SY
G
WR
S
S
G
V
LHK
A
QT
L
LQ
R
Y
MN
LA
GG
Y
S
GH
S
G
D
YST
GAAQ
V
I
MP
H
VV
GS
VEVYEQQTSW
P
L
IL
ENS
QV
VV
LW
G
M
NP
LN
T
LKIAWSSTDEQ
GL
E
Y
F-
-
H
QLK
KS
GK
P
V
I
A
IDP
IR
S
E
T
IEFF
G
DNAT
W
IAPNM
GTD
V
AL
ML
GIA
HT
L
M
T
QG
K
H
D
KV
FL
E
KY
TT
GY
PQ
-----
-
--
-
-
-
-
FEE
Y
LT
G
KS
-
D
N
T
P
K
SA
A
WAAEITG
V
P
EA
QI
V
KLA
-
E
LM
AA
NRTMLMA
GWG
I
QRQ
Q
Y
GEQ
K
H
WMLVT
L
AA
ML
G
QI
G
T
P
GG
GF
G
FSYHYSNGGNP
T
R
V
G
GV----
-
-
LP
E
M
S
AAIAG
Q
A
S
-
-
-
--
E
A
A
D
D
G
G-
MTAI
PVARIV
D
ALENPGGKYQHN
GKE
QTYPN
IK
M
IW
-
W
AG
GGN
F
TH
H
Q
D
T
N
R
LIK
A
W
Q
-
-
-
K
P
EMIVV
S
E
C
YW
TA
A
AK
H
ADI
V
LP
ITT
SF
E
RN
DL
T
MTGD
YS
N
Q
-
H
I
V
PM
KQ
A
VA
P
Q
FE
ARNDFD
V
FADL
A
EL
L
K
P
GGKE
I
Y
TEG
K
D
E
MA
WLKF
F
Y
DAAQKG
AR
AQ
R
V
T
MP
M
F
N
A
F
W
QQ
NK
L
IEMR
R
S
E
K
NE
Q
YV
R
Y
G
D
FR
A
DP
V
K
N
A
L
G
TPSGKIEIYS
KT
L
E
K
FGYKDCPAH
P
TW
--
-
---
-
L
A
P
--
-
-
---
-
D
E
W
K
G
T
A
D
E
K
-
Q
LQL
L
TA
H
PA
H
R
L
HS
Q
LNYA
E
L
R
K
K
YAV
A
D
R
EPIT
I
HTE
DA
A
R
F
GIANGD
L
VRV
W
N
K
RG
Q
IL
TG
A
V
VT
DG
I
KK
GV
V
C
V
HE
GAW
P
D
L
E
-
-
-
N
G
L
CKN
GS
A
N
V
LTA
D
I
PS
SQ
LA
NACA
G
N
S
A
LV
Y
IEKYTGNAPKLTAFDQPA
I
QA
fig|481805.6.peg.1891
Escherichia coli ATCC 8739
MT
LT
RR
E
F
IK
H
S
G
I
AAG
AL
-
---
-
-
---
-
--
V
V
T
S
AAP
LP
AW
A
E
EK
-
--
G
G
K
I
LTA
G
RWG
A
MNVE
VKD
GK
I
-
---
V
S
STG
A
-
-
-
-
LAKTIPNS
L
QSTAADQVHTTA
RI
Q
HP
MVRKSY
L
D
N
P
LQPAKG
RGE
DTYVQV
SW
EQ
AL
KL
I
HEQ
H
D
RI
R
K
A
N
G
PS
A
I
F
--
-
-
AG
SY
G
WR
S
S
G
V
LHK
A
QT
L
LQ
R
Y
MN
LA
GG
Y
S
GH
S
G
D
YST
GAAQ
V
I
MP
H
VV
GS
VEVYEQQTSW
P
L
IL
ENS
QV
VV
LW
G
M
NP
LN
T
LKIAWSSTDEQ
GL
E
Y
F-
-
H
QLK
KS
GK
P
V
I
A
IDP
IR
S
E
T
IEFF
G
DNAT
W
IAPNM
GTD
V
AL
ML
GIA
HT
L
M
T
QG
K
H
D
KV
FL
E
KY
TT
GY
PQ
-----
-
--
-
-
-
-
FEE
Y
LT
G
KS
-
D
N
T
P
K
SA
A
WAAEITG
V
P
EA
QI
V
KLA
-
E
LM
AA
NRTMLMA
GWG
I
QRQ
Q
Y
GEQ
K
H
WMLVT
L
AA
ML
G
QI
G
T
P
GG
GF
G
FSYHYSNGGNP
T
R
V
G
GV----
-
-
LP
E
M
S
AAIAG
Q
A
S
-
-
-
--
E
A
A
D
D
G
G-
MTAI
PVARIV
D
ALENPGGKYQHN
GKE
QTYPN
IK
M
IW
-
W
AG
GGN
F
TH
H
Q
D
T
N
R
LIK
A
W
Q
-
-
-
K
P
EMIVV
S
E
C
YW
TA
A
AK
H
ADI
V
LP
ITT
SF
E
RN
DL
T
MTGD
YS
N
Q
-
H
I
V
PM
KQ
A
VA
P
Q
FE
ARNDFD
V
FADL
A
EL
L
K
P
GGKE
I
Y
TEG
K
D
E
MA
WLKF
F
Y
DAAQKG
AR
AQ
R
V
T
MP
M
F
N
A
F
W
QQ
NK
L
IEMR
R
S
E
K
NE
Q
YV
R
Y
G
D
FR
A
DP
V
K
N
A
L
G
TPSGKIEIYS
KT
L
E
K
FGYKDCPAH
P
TW
--
-
---
-
L
A
P
--
-
-
---
-
D
E
W
K
G
T
A
D
E
K
-
Q
LQL
L
TA
H
PA
H
R
L
HS
Q
LNYA
E
L
R
K
K
YAV
A
D
R
EPIT
I
HTE
DA
A
R
F
GIANGD
L
VRV
W
N
K
RG
Q
IL
TG
A
V
VT
DG
I
KK
GV
V
C
V
HE
GAW
P
D
L
E
-
-
-
N
G
L
CKN
GS
A
N
V
LTA
D
I
PS
SQ
LA
NACA
G
N
S
A
LV
Y
IEKYTGNAPKLTAFDQPA
I
QA
fig|413997.3.peg.1930
Escherichia coli B str. REL606
MT
LT
RR
E
F
IK
H
S
G
I
AAG
AL
-
---
-
-
---
-
--
V
V
T
S
AAP
LP
AW
A
E
EK
-
--
G
G
K
I
LTA
G
RWG
A
MNVE
VKD
GK
I
-
---
V
S
STG
A
-
-
-
-
LAKTIPNS
L
QSTAADQVHTTA
RI
Q
HP
MVRKSY
L
D
N
P
LQPAKG
RGE
DTYVQV
SW
EQ
AL
KL
I
HEQ
H
D
RI
R
K
A
N
G
PS
A
I
F
--
-
-
AG
SY
G
WR
S
S
G
V
LHK
A
QT
L
LQ
R
Y
MN
LA
GG
Y
S
GH
S
G
D
YST
GAAQ
V
I
MP
H
VV
GS
VEVYEQQTSW
P
L
IL
ENS
QV
VV
LW
G
M
NP
LN
T
LKIAWSSTDEQ
GL
E
Y
F-
-
H
QLK
KS
GK
P
V
I
A
IDP
IR
S
E
T
IEFF
G
DNAT
W
IAPNM
GTD
V
AL
ML
GIA
HT
L
M
T
QG
K
H
D
KV
FL
E
KY
TT
GY
PQ
-----
-
--
-
-
-
-
FEE
Y
LT
G
KS
-
D
N
T
P
K
SA
A
WAAEITG
V
P
EA
QI
V
KLA
-
E
LM
AA
NRTMLMA
GWG
I
QRQ
Q
Y
GEQ
K
H
WMLVT
L
AA
ML
G
QI
G
T
P
GG
GF
G
FSYHYSNGGNP
T
R
V
G
GV----
-
-
LP
E
M
S
AAIAG
Q
A
S
-
-
-
--
E
A
A
D
D
G
G-
MTAI
PVARIV
D
ALENPGGKYQHN
GKE
QTYPN
IK
M
IW
-
W
AG
GGN
F
TH
H
Q
D
T
N
R
LIK
A
W
Q
-
-
-
K
P
EMIVV
S
E
C
YW
TA
A
AK
H
ADI
V
LP
ITT
SF
E
RN
DL
T
MTGD
YS
N
Q
-
H
I
V
PM
KQ
A
VA
P
Q
FE
ARNDFD
V
FADL
A
EL
L
K
P
GGKE
I
Y
TEG
K
D
E
MA
WLKF
F
Y
DAAQKG
AR
AQ
R
V
T
MP
M
F
N
A
F
W
QQ
NK
L
IEMR
R
S
E
K
NE
Q
YV
R
Y
G
D
FR
A
DP
V
K
N
A
L
G
TPSGKIEIYS
KT
L
E
K
FGYKDCPAH
P
TW
--
-
---
-
L
A
P
--
-
-
---
-
D
E
W
K
G
T
A
D
E
K
-
Q
LQL
L
TA
H
PA
H
R
L
HS
Q
LNYA
E
L
R
K
K
YAV
A
D
R
EPIT
I
HTE
DA
A
R
F
GIANGD
L
VRV
W
N
K
RG
Q
IL
TG
A
V
VT
DG
I
KK
GV
V
C
V
HE
GAW
P
D
L
E
-
-
-
N
G
L
CKN
GS
A
N
V
LTA
D
I
PS
SQ
LA
NACA
G
N
S
A
LV
Y
IEKYTGNAPKLTAFDQPA
I
QA
fig|469008.4.peg.1820
Escherichia coli BL21(DE3)
MT
LT
RR
E
F
IK
H
S
G
I
AAG
AL
-
---
-
-
---
-
--
V
V
T
S
AAP
LP
AW
A
E
EK
-
--
G
G
K
I
LTA
G
RWG
A
MNVE
VKD
GK
I
-
---
V
S
STG
A
-
-
-
-
LAKTIPNS
L
QSTAADQVHTTA
RI
Q
HP
MVRKSY
L
D
N
P
LQPAKG
RGE
DTYVQV
SW
EQ
AL
KL
I
HEQ
H
D
RI
R
K
A
N
G
PS
A
I
F
--
-
-
AG
SY
G
WR
S
S
G
V
LHK
A
QT
L
LQ
R
Y
MN
LA
GG
Y
S
GH
S
G
D
YST
GAAQ
V
I
MP
H
VV
GS
VEVYEQQTSW
P
L
IL
ENS
QV
VV
LW
G
M
NP
LN
T
LKIAWSSTDEQ
GL
E
Y
F-
-
H
QLK
KS
GK
P
V
I
A
IDP
IR
S
E
T
IEFF
G
DNAT
W
IAPNM
GTD
V
AL
ML
GIA
HT
L
M
T
QG
K
H
D
KV
FL
E
KY
TT
GY
PQ
-----
-
--
-
-
-
-
FEE
Y
LT
G
KS
-
D
N
T
P
K
SA
A
WAAEITG
V
P
EA
QI
V
KLA
-
E
LM
AA
NRTMLMA
GWG
I
QRQ
Q
Y
GEQ
K
H
WMLVT
L
AA
ML
G
QI
G
T
P
GG
GF
G
FSYHYSNGGNP
T
R
V
G
GV----
-
-
LP
E
M
S
AAIAG
Q
A
S
-
-
-
--
E
A
A
D
D
G
G-
MTAI
PVARIV
D
ALENPGGKYQHN
GKE
QTYPN
IK
M
IW
-
W
AG
GGN
F
TH
H
Q
D
T
N
R
LIK
A
W
Q
-
-
-
K
P
EMIVV
S
E
C
YW
TA
A
AK
H
ADI
V
LP
ITT
SF
E
RN
DL
T
MTGD
YS
N
Q
-
H
I
V
PM
KQ
A
VA
P
Q
FE
ARNDFD
V
FADL
A
EL
L
K
P
GGKE
I
Y
TEG
K
D
E
MA
WLKF
F
Y
DAAQKG
AR
AQ
R
V
T
MP
M
F
N
A
F
W
QQ
NK
L
IEMR
R
S
E
K
NE
Q
YV
R
Y
G
D
FR
A
DP
V
K
N
A
L
G
TPSGKIEIYS
KT
L
E
K
FGYKDCPAH
P
TW
--
-
---
-
L
A
P
--
-
-
---
-
D
E
W
K
G
T
A
D
E
K
-
Q
LQL
L
TA
H
PA
H
R
L
HS
Q
LNYA
E
L
R
K
K
YAV
A
D
R
EPIT
I
HTE
DA
A
R
F
GIANGD
L
VRV
W
N
K
RG
Q
IL
TG
A
V
VT
DG
I
KK
GV
V
C
V
HE
GAW
P
D
L
E
-
-
-
N
G
L
CKN
GS
A
N
V
LTA
D
I
PS
SQ
LA
NACA
G
N
S
A
LV
Y
IEKYTGNAPKLTAFDQPA
I
QA
fig|331112.3.peg.1852
Escherichia coli HS
MT
LT
RR
E
F
IK
H
S
G
I
AAG
AL
-
---
-
-
---
-
--
V
V
T
S
AAP
LP
AW
A
E
EK
-
--
G
G
K
I
LTA
G
RWG
A
MNVE
VKD
GK
I
-
---
V
S
STG
A
-
-
-
-
LAKTIPNS
L
QSTAADQVHTTA
RI
Q
HP
MVRKSY
L
D
N
P
LQPAKG
RGE
DTYVQV
SW
EQ
AL
KL
I
HEQ
H
D
RI
R
K
A
N
G
PS
A
I
F
--
-
-
AG
SY
G
WR
S
S
G
V
LHK
A
QT
L
LQ
R
Y
MN
LA
GG
Y
S
GH
S
G
D
YST
GAAQ
V
I
MP
H
VV
GS
VEVYEQQTSW
P
L
IL
ENS
QV
VV
LW
G
M
NP
LN
T
LKIAWSSTDEQ
GL
E
Y
F-
-
H
QLK
KS
GK
P
V
I
A
IDP
IR
S
E
T
IEFF
G
DNAT
W
IAPNM
GTD
V
AL
ML
GIA
HT
L
M
T
QG
K
H
D
KV
FL
E
KY
TT
GY
PQ
-----
-
--
-
-
-
-
FEE
Y
LT
G
KS
-
D
N
T
P
K
SA
A
WAAEITG
V
P
EA
QI
V
KLA
-
E
LM
AA
NRTMLMA
GWG
I
QRQ
Q
Y
GEQ
K
H
WMLVT
L
AA
ML
G
QI
G
T
P
GG
GF
G
FSYHYSNGGNP
T
R
V
G
GV----
-
-
LP
E
M
S
AAIAG
Q
A
S
-
-
-
--
E
A
A
D
D
G
G-
MTAI
PVARIV
D
ALENPGGKYQHN
GKE
QTYPN
IK
M
IW
-
W
AG
GGN
F
TH
H
Q
D
T
N
R
LIK
A
W
Q
-
-
-
K
P
EMIVV
S
E
C
YW
TA
A
AK
H
ADI
V
LP
ITT
SF
E
RN
DL
T
MTGD
YS
N
Q
-
H
I
V
PM
KQ
A
VA
P
Q
FE
ARNDFD
V
FADL
A
EL
L
K
P
GGKE
I
Y
TEG
K
D
E
MA
WLKF
F
Y
DAAQKG
AR
AQ
R
V
T
MP
M
F
N
A
F
W
QQ
NK
L
IEMR
R
S
E
K
NE
Q
YV
R
Y
G
D
FR
A
DP
V
K
N
A
L
G
TPSGKIEIYS
KT
L
E
K
FGYKDCPAH
P
TW
--
-
---
-
L
A
P
--
-
-
---
-
D
E
W
K
G
T
A
D
E
K
-
Q
LQL
L
TA
H
PA
H
R
L
HS
Q
LNYA
E
L
R
K
K
YAV
A
D
R
EPIT
I
HTE
DA
A
R
F
GIANGD
L
VRV
W
N
K
RG
Q
IL
TG
A
V
VT
DG
I
KK
GV
V
C
V
HE
GAW
P
D
L
E
-
-
-
N
G
L
CKN
GS
A
N
V
LTA
D
I
PS
SQ
LA
NACA
G
N
S
A
LV
Y
IEKYTGNAPKLTAFDQPA
I
QA
fig|331112.6.peg.1927
Escherichia coli HS
MT
LT
RR
E
F
IK
H
S
G
I
AAG
AL
-
---
-
-
---
-
--
V
V
T
S
AAP
LP
AW
A
E
EK
-
--
G
G
K
I
LTA
G
RWG
A
MNVE
VKD
GK
I
-
---
V
S
STG
A
-
-
-
-
LAKTIPNS
L
QSTAADQVHTTA
RI
Q
HP
MVRKSY
L
D
N
P
LQPAKG
RGE
DTYVQV
SW
EQ
AL
KL
I
HEQ
H
D
RI
R
K
A
N
G
PS
A
I
F
--
-
-
AG
SY
G
WR
S
S
G
V
LHK
A
QT
L
LQ
R
Y
MN
LA
GG
Y
S
GH
S
G
D
YST
GAAQ
V
I
MP
H
VV
GS
VEVYEQQTSW
P
L
IL
ENS
QV
VV
LW
G
M
NP
LN
T
LKIAWSSTDEQ
GL
E
Y
F-
-
H
QLK
KS
GK
P
V
I
A
IDP
IR
S
E
T
IEFF
G
DNAT
W
IAPNM
GTD
V
AL
ML
GIA
HT
L
M
T
QG
K
H
D
KV
FL
E
KY
TT
GY
PQ
-----
-
--
-
-
-
-
FEE
Y
LT
G
KS
-
D
N
T
P
K
SA
A
WAAEITG
V
P
EA
QI
V
KLA
-
E
LM
AA
NRTMLMA
GWG
I
QRQ
Q
Y
GEQ
K
H
WMLVT
L
AA
ML
G
QI
G
T
P
GG
GF
G
FSYHYSNGGNP
T
R
V
G
GV----
-
-
LP
E
M
S
AAIAG
Q
A
S
-
-
-
--
E
A
A
D
D
G
G-
MTAI
PVARIV
D
ALENPGGKYQHN
GKE
QTYPN
IK
M
IW
-
W
AG
GGN
F
TH
H
Q
D
T
N
R
LIK
A
W
Q
-
-
-
K
P
EMIVV
S
E
C
YW
TA
A
AK
H
ADI
V
LP
ITT
SF
E
RN
DL
T
MTGD
YS
N
Q
-
H
I
V
PM
KQ
A
VA
P
Q
FE
ARNDFD
V
FADL
A
EL
L
K
P
GGKE
I
Y
TEG
K
D
E
MA
WLKF
F
Y
DAAQKG
AR
AQ
R
V
T
MP
M
F
N
A
F
W
QQ
NK
L
IEMR
R
S
E
K
NE
Q
YV
R
Y
G
D
FR
A
DP
V
K
N
A
L
G
TPSGKIEIYS
KT
L
E
K
FGYKDCPAH
P
TW
--
-
---
-
L
A
P
--
-
-
---
-
D
E
W
K
G
T
A
D
E
K
-
Q
LQL
L
TA
H
PA
H
R
L
HS
Q
LNYA
E
L
R
K
K
YAV
A
D
R
EPIT
I
HTE
DA
A
R
F
GIANGD
L
VRV
W
N
K
RG
Q
IL
TG
A
V
VT
DG
I
KK
GV
V
C
V
HE
GAW
P
D
L
E
-
-
-
N
G
L
CKN
GS
A
N
V
LTA
D
I
PS
SQ
LA
NACA
G
N
S
A
LV
Y
IEKYTGNAPKLTAFDQPA
I
QA
fig|344601.3.peg.3663
Escherichia coli B171
MT
LT
RR
E
F
IK
H
S
G
I
AAG
AL
-
---
-
-
---
-
--
V
V
T
S
AAP
LP
AW
A
E
EK
-
--
G
G
K
I
LTA
G
RWG
A
MNVE
VKD
GK
I
-
---
V
S
STG
A
-
-
-
-
LAKTIPNS
L
QSTAADQVHTTA
RI
Q
HP
MVRKSY
L
D
N
P
LQPAKG
RGE
DTYVQV
SW
EQ
AL
KL
I
HEQ
H
D
RI
R
K
A
N
G
PS
A
I
F
--
-
-
AG
SY
G
WR
S
S
G
V
LHK
A
QT
L
LQ
R
Y
MN
LA
GG
Y
S
GH
S
G
D
YST
GAAQ
V
I
MP
H
VV
GS
VEVYEQQTSW
P
L
IL
ENS
Q
A
VV
LW
G
M
NP
LN
T
LKIAWSSTDEQ
GL
E
Y
F-
-
H
QLK
KS
GK
P
V
I
A
IDP
IR
S
E
T
IEFF
G
DNAT
W
IAPNM
GTD
V
AL
ML
GIA
HT
L
M
T
QG
K
H
D
KV
FL
E
KY
TT
GY
PQ
-----
-
--
-
-
-
-
FEE
Y
LT
G
KS
-
D
N
T
P
K
SA
A
WAAEITG
V
P
EA
QI
V
KLA
-
E
LM
AA
NRTMLMA
GWG
I
QRQ
Q
Y
GEQ
K
H
WMLVT
L
AA
ML
G
QI
G
T
P
GG
GF
G
FSYHYSNGGNP
T
R
V
G
GV----
-
-
LP
E
M
S
AAIAG
Q
A
S
-
-
-
--
E
A
A
D
D
G
G-
MTAI
PVARIV
D
ALENPGGKYQHN
GKE
QTYPN
IK
M
IW
-
W
AG
GGN
F
TH
H
Q
D
T
N
R
LIK
A
W
Q
-
-
-
K
P
EMIVV
S
E
C
YW
TA
A
AK
H
ADI
V
LP
ITT
SF
E
RN
DL
T
MTGD
YS
N
Q
-
H
I
V
PM
KQ
A
VA
P
Q
FE
ARNDFD
V
FADL
A
EL
L
K
P
GGKE
I
Y
TEG
K
D
E
MA
WLKF
F
Y
DAAQKG
AR
AQ
R
V
T
MP
M
F
N
A
F
W
QQ
NK
L
IEMR
R
S
E
K
NE
Q
YV
R
Y
A
D
FR
A
DP
V
K
N
A
L
G
TPSGKIEIYS
KT
L
E
K
FGYKDCPAH
P
TW
--
-
---
-
L
A
P
--
-
-
---
-
D
E
W
K
G
T
A
D
E
K
-
Q
LQL
L
TA
H
PA
H
R
L
HS
Q
LNYA
E
L
R
K
K
YAV
A
D
R
EPIT
I
HTE
DA
A
R
F
GIANGD
L
VRV
W
N
K
RG
Q
IL
TG
A
V
VT
DG
I
KK
GV
V
C
V
HE
GAW
P
D
L
E
-
-
-
N
G
L
CKN
GS
A
N
V
LTA
D
I
PS
SQ
LA
NACA
G
N
S
A
LV
Y
IEKYTGNAPKLTAFDQPA
I
QA
fig|344601.5.peg.3822
Escherichia coli B171
MT
LT
RR
E
F
IK
H
S
G
I
AAG
AL
-
---
-
-
---
-
--
V
V
T
S
AAP
LP
AW
A
E
EK
-
--
G
G
K
I
LTA
G
RWG
A
MNVE
VKD
GK
I
-
---
V
S
STG
A
-
-
-
-
LAKTIPNS
L
QSTAADQVHTTA
RI
Q
HP
MVRKSY
L
D
N
P
LQPAKG
RGE
DTYVQV
SW
EQ
AL
KL
I
HEQ
H
D
RI
R
K
A
N
G
PS
A
I
F
--
-
-
AG
SY
G
WR
S
S
G
V
LHK
A
QT
L
LQ
R
Y
MN
LA
GG
Y
S
GH
S
G
D
YST
GAAQ
V
I
MP
H
VV
GS
VEVYEQQTSW
P
L
IL
ENS
Q
A
VV
LW
G
M
NP
LN
T
LKIAWSSTDEQ
GL
E
Y
F-
-
H
QLK
KS
GK
P
V
I
A
IDP
IR
S
E
T
IEFF
G
DNAT
W
IAPNM
GTD
V
AL
ML
GIA
HT
L
M
T
QG
K
H
D
KV
FL
E
KY
TT
GY
PQ
-----
-
--
-
-
-
-
FEE
Y
LT
G
KS
-
D
N
T
P
K
SA
A
WAAEITG
V
P
EA
QI
V
KLA
-
E
LM
AA
NRTMLMA
GWG
I
QRQ
Q
Y
GEQ
K
H
WMLVT
L
AA
ML
G
QI
G
T
P
GG
GF
G
FSYHYSNGGNP
T
R
V
G
GV----
-
-
LP
E
M
S
AAIAG
Q
A
S
-
-
-
--
E
A
A
D
D
G
G-
MTAI
PVARIV
D
ALENPGGKYQHN
GKE
QTYPN
IK
M
IW
-
W
AG
GGN
F
TH
H
Q
D
T
N
R
LIK
A
W
Q
-
-
-
K
P
EMIVV
S
E
C
YW
TA
A
AK
H
ADI
V
LP
ITT
SF
E
RN
DL
T
MTGD
YS
N
Q
-
H
I
V
PM
KQ
A
VA
P
Q
FE
ARNDFD
V
FADL
A
EL
L
K
P
GGKE
I
Y
TEG
K
D
E
MA
WLKF
F
Y
DAAQKG
AR
AQ
R
V
T
MP
M
F
N
A
F
W
QQ
NK
L
IEMR
R
S
E
K
NE
Q
YV
R
Y
A
D
FR
A
DP
V
K
N
A
L
G
TPSGKIEIYS
KT
L
E
K
FGYKDCPAH
P
TW
--
-
---
-
L
A
P
--
-
-
---
-
D
E
W
K
G
T
A
D
E
K
-
Q
LQL
L
TA
H
PA
H
R
L
HS
Q
LNYA
E
L
R
K
K
YAV
A
D
R
EPIT
I
HTE
DA
A
R
F
GIANGD
L
VRV
W
N
K
RG
Q
IL
TG
A
V
VT
DG
I
KK
GV
V
C
V
HE
GAW
P
D
L
E
-
-
-
N
G
L
CKN
GS
A
N
V
LTA
D
I
PS
SQ
LA
NACA
G
N
S
A
LV
Y
IEKYTGNAPKLTAFDQPA
I
QA
fig|340185.3.peg.3839
Escherichia coli E22
MT
LT
RR
E
F
IK
H
S
G
I
AAG
AL
-
---
-
-
---
-
--
V
V
T
S
AAP
LP
AW
A
E
EK
-
--
G
G
K
I
LTA
G
RWG
A
MNVE
VKD
GK
I
-
---
V
S
STG
A
-
-
-
-
LAKTIPNS
L
QSTAADQVHTTA
RI
Q
HP
MVRKSY
L
D
N
P
LQPAKG
RGE
DTYVQV
SW
EQ
AL
KL
I
HEQ
H
D
RI
R
K
A
N
G
PS
A
I
F
--
-
-
AG
SY
G
WR
S
S
G
V
LHK
A
QT
L
LQ
R
Y
MN
LA
GG
Y
S
GH
S
G
D
YST
GAAQ
V
I
MP
H
VV
GS
VEVYEQQTSW
P
L
IL
ENS
Q
A
VV
LW
G
M
NP
LN
T
LKIAWSSTDEQ
GL
E
Y
F-
-
H
QLK
KS
GK
P
V
I
A
IDP
IR
S
E
T
IEFF
G
DNAT
W
IAPNM
GTD
V
AL
ML
GIA
HT
L
M
T
QG
K
H
D
KV
FL
E
KY
TT
GY
PQ
-----
-
--
-
-
-
-
FEE
Y
LT
G
KS
-
D
N
T
P
K
SA
A
WAAEITG
V
P
EA
QI
V
KLA
-
E
LM
AA
NRTMLMA
GWG
I
QRQ
Q
Y
GEQ
K
H
WMLVT
L
AA
ML
G
QI
G
T
P
GG
GF
G
FSYHYSNGGNP
T
R
V
G
GV----
-
-
LP
E
M
S
AAIAG
Q
A
S
-
-
-
--
E
A
A
D
D
G
G-
MTAI
PVARIV
D
ALENPGGKYQHN
GKE
QTYPN
IK
M
IW
-
W
AG
GGN
F
TH
H
Q
D
T
N
R
LIK
A
W
Q
-
-
-
K
P
EMIVV
S
E
C
YW
TA
A
AK
H
ADI
V
LP
ITT
SF
E
RN
DL
T
MTGD
YS
N
Q
-
H
I
V
PM
KQ
A
VA
P
Q
FE
ARNDFD
V
FADL
A
EL
L
K
P
GGKE
I
Y
TEG
K
D
E
MA
WLKF
F
Y
DAAQKG
AR
AQ
R
V
T
MP
M
F
N
A
F
W
QQ
NK
L
IEMR
R
S
E
K
NE
Q
YV
R
Y
A
D
FR
A
DP
V
K
N
A
L
G
TPSGKIEIYS
KT
L
E
K
FGYKDCPAH
P
TW
--
-
---
-
L
A
P
--
-
-
---
-
D
E
W
K
G
T
A
D
E
K
-
Q
LQL
L
TA
H
PA
H
R
L
HS
Q
LNYA
E
L
R
K
K
YAV
A
D
R
EPIT
I
HTE
DA
A
R
F
GIANGD
L
VRV
W
N
K
RG
Q
IL
TG
A
V
VT
DG
I
KK
GV
V
C
V
HE
GAW
P
D
L
E
-
-
-
N
G
L
CKN
GS
A
N
V
LTA
D
I
PS
SQ
LA
NACA
G
N
S
A
LV
Y
IEKYTGNAPKLTAFDQPA
I
QA
fig|340185.4.peg.4050
Escherichia coli E22
MT
LT
RR
E
F
IK
H
S
G
I
AAG
AL
-
---
-
-
---
-
--
V
V
T
S
AAP
LP
AW
A
E
EK
-
--
G
G
K
I
LTA
G
RWG
A
MNVE
VKD
GK
I
-
---
V
S
STG
A
-
-
-
-
LAKTIPNS
L
QSTAADQVHTTA
RI
Q
HP
MVRKSY
L
D
N
P
LQPAKG
RGE
DTYVQV
SW
EQ
AL
KL
I
HEQ
H
D
RI
R
K
A
N
G
PS
A
I
F
--
-
-
AG
SY
G
WR
S
S
G
V
LHK
A
QT
L
LQ
R
Y
MN
LA
GG
Y
S
GH
S
G
D
YST
GAAQ
V
I
MP
H
VV
GS
VEVYEQQTSW
P
L
IL
ENS
Q
A
VV
LW
G
M
NP
LN
T
LKIAWSSTDEQ
GL
E
Y
F-
-
H
QLK
KS
GK
P
V
I
A
IDP
IR
S
E
T
IEFF
G
DNAT
W
IAPNM
GTD
V
AL
ML
GIA
HT
L
M
T
QG
K
H
D
KV
FL
E
KY
TT
GY
PQ
-----
-
--
-
-
-
-
FEE
Y
LT
G
KS
-
D
N
T
P
K
SA
A
WAAEITG
V
P
EA
QI
V
KLA
-
E
LM
AA
NRTMLMA
GWG
I
QRQ
Q
Y
GEQ
K
H
WMLVT
L
AA
ML
G
QI
G
T
P
GG
GF
G
FSYHYSNGGNP
T
R
V
G
GV----
-
-
LP
E
M
S
AAIAG
Q
A
S
-
-
-
--
E
A
A
D
D
G
G-
MTAI
PVARIV
D
ALENPGGKYQHN
GKE
QTYPN
IK
M
IW
-
W
AG
GGN
F
TH
H
Q
D
T
N
R
LIK
A
W
Q
-
-
-
K
P
EMIVV
S
E
C
YW
TA
A
AK
H
ADI
V
LP
ITT
SF
E
RN
DL
T
MTGD
YS
N
Q
-
H
I
V
PM
KQ
A
VA
P
Q
FE
ARNDFD
V
FADL
A
EL
L
K
P
GGKE
I
Y
TEG
K
D
E
MA
WLKF
F
Y
DAAQKG
AR
AQ
R
V
T
MP
M
F
N
A
F
W
QQ
NK
L
IEMR
R
S
E
K
NE
Q
YV
R
Y
A
D
FR
A
DP
V
K
N
A
L
G
TPSGKIEIYS
KT
L
E
K
FGYKDCPAH
P
TW
--
-
---
-
L
A
P
--
-
-
---
-
D
E
W
K
G
T
A
D
E
K
-
Q
LQL
L
TA
H
PA
H
R
L
HS
Q
LNYA
E
L
R
K
K
YAV
A
D
R
EPIT
I
HTE
DA
A
R
F
GIANGD
L
VRV
W
N
K
RG
Q
IL
TG
A
V
VT
DG
I
KK
GV
V
C
V
HE
GAW
P
D
L
E
-
-
-
N
G
L
CKN
GS
A
N
V
LTA
D
I
PS
SQ
LA
NACA
G
N
S
A
LV
Y
IEKYTGNAPKLTAFDQPA
I
QA
fig|585395.4.peg.2235
Escherichia coli O103:H2 str. 12009
MT
LT
RR
E
F
IK
H
S
G
I
AAG
AL
-
---
-
-
---
-
--
V
V
T
S
AAP
LP
AW
A
E
EK
-
--
G
G
K
I
LTA
G
RWG
A
MNVE
VKD
GK
I
-
---
V
S
STG
A
-
-
-
-
LAKTIPNS
L
QSTAADQVHTTA
RI
Q
HP
MVRKSY
L
D
N
P
LQPAKG
RGE
DTYVQV
SW
EQ
AL
KL
I
HEQ
H
D
RI
R
K
A
N
G
PS
A
I
F
--
-
-
AG
SY
G
WR
S
S
G
V
LHK
A
QT
L
LQ
R
Y
MN
LA
GG
Y
S
GH
S
G
D
YST
GAAQ
V
I
MP
H
VV
GS
VEVYEQQTSW
P
L
IL
ENS
Q
A
VV
LW
G
M
NP
LN
T
LKIAWSSTDEQ
GL
E
Y
F-
-
H
QLK
KS
GK
P
V
I
A
IDP
IR
S
E
T
IEFF
G
DNAT
W
IAPNM
GTD
V
AL
ML
GIA
HT
L
M
T
QG
K
H
D
KV
FL
E
KY
TT
GY
PQ
-----
-
--
-
-
-
-
FEE
Y
LT
G
KS
-
D
N
T
P
K
SA
A
WAAEITG
V
P
EA
QI
V
KLA
-
E
LM
AA
NRTMLMA
GWG
I
QRQ
Q
Y
GEQ
K
H
WMLVT
L
AA
ML
G
QI
G
T
P
GG
GF
G
FSYHYSNGGNP
T
R
V
G
GV----
-
-
LP
E
M
S
AAIAG
Q
A
S
-
-
-
--
E
A
A
D
D
G
G-
MTAI
PVARIV
D
ALENPGGKYQHN
GKE
QTYPN
IK
M
IW
-
W
AG
GGN
F
TH
H
Q
D
T
N
R
LIK
A
W
Q
-
-
-
K
P
EMIVV
S
E
C
YW
TA
A
AK
H
ADI
V
LP
ITT
SF
E
RN
DL
T
MTGD
YS
N
Q
-
H
I
V
PM
KQ
A
VA
P
Q
FE
ARNDFD
V
FADL
A
EL
L
K
P
GGKE
I
Y
TEG
K
D
E
MA
WLKF
F
Y
DAAQKG
AR
AQ
R
V
T
MP
M
F
N
A
F
W
QQ
NK
L
IEMR
R
S
E
K
NE
Q
YV
R
Y
A
D
FR
A
DP
V
K
N
A
L
G
TPSGKIEIYS
KT
L
E
K
FGYKDCPAH
P
TW
--
-
---
-
L
A
P
--
-
-
---
-
D
E
W
K
G
T
A
D
E
K
-
Q
LQL
L
TA
H
PA
H
R
L
HS
Q
LNYA
E
L
R
K
K
YAV
A
D
R
EPIT
I
HTE
DA
A
R
F
GIANGD
L
VRV
W
N
K
RG
Q
IL
TG
A
V
VT
DG
I
KK
GV
V
C
V
HE
GAW
P
D
L
E
-
-
-
N
G
L
CKN
GS
A
N
V
LTA
D
I
PS
SQ
LA
NACA
G
N
S
A
LV
Y
IEKYTGNAPKLTAFDQPA
I
QA
fig|679206.4.peg.2130
Escherichia coli MS 119-7
MT
LT
RR
E
F
IK
H
S
G
I
AAG
AL
-
---
-
-
---
-
--
V
V
T
S
AAP
LP
AW
A
E
EK
-
--
G
G
K
I
LTA
G
RWG
A
MNVE
VKD
GK
I
-
---
V
S
STG
A
-
-
-
-
LAKTIPNS
L
QSTAADQVHTTA
RI
Q
HP
MVRKSY
L
D
N
P
LQPAKG
RGE
DTYVQV
SW
EQ
AL
KL
I
HEQ
H
D
RI
R
K
A
N
G
PS
A
I
F
--
-
-
AG
SY
G
WR
S
S
G
V
LHK
A
QT
L
LQ
R
Y
MN
LA
GG
Y
S
GH
S
G
D
YST
GAAQ
V
I
MP
H
VV
GS
VEVYEQQTSW
P
L
IL
ENS
QV
VV
LW
G
M
NP
LN
T
LKIAWSSTDEQ
GL
E
Y
F-
-
H
QLK
KS
GK
P
V
I
A
IDP
IR
S
E
T
IEFF
G
DNAT
W
IAPNM
GTD
V
AL
ML
GIA
HT
L
M
T
QG
K
H
D
KV
FL
E
KY
TT
GY
PQ
-----
-
--
-
-
-
-
FEE
Y
LT
G
KS
-
D
N
T
P
K
SA
A
WAAEITG
V
P
EA
QI
V
KLA
-
E
LM
AA
NRTMLMA
GWG
I
QRQ
Q
Y
GEQ
K
H
WMLVT
L
AA
ML
G
QI
G
T
P
GG
GF
G
FSYHYSNGGNP
T
R
V
G
GV----
-
-
LP
E
M
S
AAIAG
Q
A
S
-
-
-
--
E
A
A
D
D
G
G-
MTAI
PVARIV
D
ALENPGGKYQHN
GKE
QTYPN
IK
M
IW
-
W
AG
GGN
F
TH
H
Q
D
T
N
R
LIK
A
W
Q
-
-
-
K
P
EMIVV
S
E
C
YW
TA
A
AK
H
ADI
V
LP
ITT
SF
E
RN
DL
T
MTGD
YS
N
Q
-
H
I
V
PM
KQ
A
VA
P
Q
FE
ARNDFD
V
FADL
A
EL
L
K
P
GGKE
I
Y
TEG
K
D
E
MA
WLKF
F
Y
DAAQKG
AR
AQ
R
V
T
MP
M
F
N
A
F
W
QQ
NK
L
IEMR
R
S
E
K
NE
Q
YV
R
Y
G
D
FR
A
DP
V
K
N
A
L
G
TPSGKIEIYS
KT
L
E
K
FGYKDCPAH
P
TW
--
-
---
-
L
A
P
--
-
-
---
-
D
E
W
K
G
T
A
D
E
K
-
Q
LQL
L
TA
H
PA
H
R
L
HS
Q
LNYA
E
L
R
K
K
YAV
A
D
R
EPIT
I
HTE
DA
A
R
F
GIANGD
L
VRV
W
N
K
RG
Q
IL
TG
A
V
VT
DG
I
KK
GV
V
C
V
HE
GAW
P
D
L
E
-
-
-
N
G
L
CKN
GS
A
N
V
LTA
D
I
PS
SQ
LA
NACA
G
N
S
A
LV
Y
IEKYTGNAPKLTAFDQPAVQA
fig|656408.3.peg.2047
Escherichia coli H591
MT
LT
RR
E
F
IK
H
S
G
I
AAG
AL
-
---
-
-
---
-
--
V
V
T
S
AAP
LP
AW
A
E
EK
-
--
G
G
K
I
LTA
G
RWG
A
M
S
VE
VKD
GK
I
-
---
V
S
STG
A
-
-
-
-
LAKTIPNS
L
QSTAADQVHTTA
RI
Q
HP
MVRKSY
L
D
N
P
LQPAKG
RGE
DTYVQV
SW
EQ
AL
KL
I
HEQ
H
D
RI
R
K
A
N
G
PS
A
I
F
--
-
-
AG
SY
G
WR
S
S
G
V
LHK
A
QT
L
LQ
R
Y
MN
LA
GG
Y
S
GH
S
G
D
YST
GAAQ
V
I
MP
H
VV
GS
VEVYEQQTSW
P
L
IL
ENS
Q
A
VV
LW
G
M
NP
LN
T
LKIAWSSTDEQ
GL
E
Y
F-
-
H
QLK
KS
GK
P
V
I
A
IDP
IR
S
E
T
IEFF
G
DNAT
W
IAPNM
GTD
V
AL
ML
GIA
HT
L
M
T
QG
K
H
D
KV
FL
E
KY
TT
GY
PQ
-----
-
--
-
-
-
-
FEE
Y
LT
G
KS
-
D
N
T
P
K
SA
A
WAAEITG
V
P
EA
QI
V
KLA
-
E
LM
AA
NRTMLMA
GWG
I
QRQ
Q
Y
GEQ
K
H
WMLVT
L
AA
ML
G
QI
G
T
P
GG
GF
G
FSYHYSNGGNP
T
R
V
G
GV----
-
-
LP
E
M
S
AAIAG
Q
A
S
-
-
-
--
E
A
A
D
D
G
G-
MTAI
PVARIV
D
ALENPGGKYQHN
GKE
QTYPN
IK
M
IW
-
W
AG
GGN
F
TH
H
Q
D
T
N
R
LIK
A
W
Q
-
-
-
K
P
EMIVV
S
E
C
YW
TA
A
AK
H
ADI
V
LP
ITT
SF
E
RN
DL
T
MTGD
YS
N
Q
-
H
I
V
PM
KQ
A
VA
P
Q
FE
ARNDFD
V
FADL
A
EL
L
K
P
GGKE
I
Y
TEG
K
D
E
MA
WLKF
F
Y
DAAQKG
AR
AQ
R
V
T
MP
M
F
N
A
F
W
QQ
NK
L
IEMR
R
S
E
K
NE
Q
YV
R
Y
A
D
FR
A
DP
V
K
N
A
L
G
TPSGKIEIYS
KT
L
E
K
FGYKDCPAH
P
TW
--
-
---
-
L
A
P
--
-
-
---
-
D
E
W
K
G
T
A
D
E
K
-
Q
LQL
L
TA
H
PA
H
R
L
HS
Q
LNYA
E
L
R
K
K
YAV
A
D
R
EPIT
I
HTE
DA
A
R
F
GIANGD
L
VRV
W
N
K
RG
Q
IL
TG
A
V
VT
DG
I
KK
GV
V
C
V
HE
GAW
P
D
L
E
-
-
-
N
G
L
CKN
GS
A
N
V
LTA
D
I
PS
SQ
LA
NACA
G
N
S
A
LV
Y
IEKYTGNAPKLTAFDQPA
I
QA
fig|701177.3.peg.2329
Escherichia coli O55:H7 str. CB9615
MT
LT
RR
E
F
IK
H
S
G
I
AAG
AL
-
---
-
-
---
-
--
V
V
T
S
AAP
LP
AW
A
E
EK
-
--
G
G
K
I
LTA
G
RWG
A
MNVE
VKD
GK
I
-
---
V
S
STG
A
-
-
-
-
LAKTIPNS
L
QSTAADQVHTTA
RI
Q
HP
MVRKSY
L
D
N
P
LQPAKG
RGE
DTYVQV
SW
EQ
AL
KL
I
HEQ
H
E
RI
R
K
A
N
G
PS
A
I
F
--
-
-
AG
SY
G
WR
S
S
G
V
LHK
A
QT
L
LQ
R
Y
MN
LA
GG
Y
S
GH
S
G
D
YST
GAAQ
V
I
MP
H
VV
GS
VEVYEQQTSW
P
L
IL
ENS
QV
VV
LW
G
M
NP
LN
T
LKIAWSSTDEQ
GL
E
Y
F-
-
H
QLK
KS
GK
P
V
I
A
IDP
IR
S
E
T
IEFF
G
DNAT
W
IAPNM
GTD
V
AL
ML
GIA
HT
L
M
T
QG
K
H
D
KV
FL
E
KY
TT
GY
PQ
-----
-
--
-
-
-
-
FEE
Y
LT
G
KS
-
D
N
T
P
K
SA
A
WAAEITG
V
P
EA
QI
V
KLA
-
E
LM
AA
NRTMLMA
GWG
I
QRQ
Q
Y
GEQ
K
H
WMLVT
L
AA
ML
G
QI
G
T
P
GG
GF
G
FSYHYSNGGNP
T
R
V
G
GV----
-
-
LP
E
M
S
AAIAG
Q
A
S
-
-
-
--
E
A
A
D
D
G
G-
MTAI
PVARIV
D
ALENPGGKYQHN
GKE
QTYPN
IK
M
IW
-
W
AG
GGN
F
TH
H
Q
D
T
N
R
LIK
A
W
Q
-
-
-
K
P
EMIVV
S
E
C
YW
TA
A
AK
H
ADI
V
LP
ITT
SF
E
RN
DL
T
MTGD
YS
N
Q
-
H
I
V
PM
KQ
A
VA
P
Q
FE
ARNDFD
V
FA
E
L
A
EL
L
K
P
GGKE
I
Y
TEG
K
D
E
MA
WLKF
F
Y
DAAQKG
AR
AQ
R
V
T
MP
M
F
N
A
F
W
QQ
NK
L
IEMR
R
S
E
K
NE
Q
YV
R
Y
G
D
FR
A
DP
V
K
N
A
L
G
TPSGKIEIYS
KT
L
E
K
FGYKDCPAH
P
TW
--
-
---
-
L
A
P
--
-
-
---
-
D
E
W
K
G
T
A
D
E
K
-
Q
LQL
L
TA
H
PA
H
R
L
HS
Q
LNYA
Q
L
R
K
K
YAV
A
D
R
EPIT
I
HTE
DA
A
R
F
GIANGD
L
VRV
W
N
K
RG
Q
IL
TG
A
V
VT
DG
I
KK
GV
V
C
V
HE
GAW
P
D
L
E
-
-
-
N
G
L
CKN
GS
A
N
V
LTA
D
I
PS
SQ
LA
NACA
G
N
S
A
LV
Y
IEKYTGNAPKLTAFDQPAVQA
fig|749533.3.peg.2495
Escherichia coli MS 84-1
MT
LT
RR
E
F
IK
H
S
G
I
AAG
AL
-
---
-
-
---
-
--
V
V
T
S
AAP
LP
AW
A
E
EK
-
--
G
G
K
I
LTA
G
RWG
A
MNVE
VKD
GK
I
-
---
V
S
STG
A
-
-
-
-
LAKTIPNS
L
QSTAADQVHTTA
RI
Q
HP
MVRKSY
L
D
N
P
LQPAKG
RGE
DTYVQV
SW
EQ
AL
KL
I
HEQ
H
D
RI
R
K
A
N
G
PS
A
I
F
--
-
-
AG
SY
G
WR
S
S
G
V
LHK
A
QT
L
LQ
R
Y
MN
LA
GG
Y
S
GH
S
G
D
YST
GAAQ
V
I
MP
H
VV
GS
VEVYEQQTSW
P
L
IL
ENS
Q
A
VV
LW
G
M
NP
LN
T
LKIAWSSTDEQ
GL
E
Y
F-
-
H
QLK
KS
GK
P
V
I
A
IDP
IR
S
E
T
IEFF
G
DNAT
W
IAPNM
GTD
V
AL
ML
GIA
HT
L
M
T
QG
K
H
D
KV
FL
E
KY
TT
GY
PQ
-----
-
--
-
-
-
-
FEE
Y
LT
G
KS
-
D
N
T
P
K
SA
A
WAAEITG
V
P
EA
QI
V
KLA
-
E
LM
AA
NRTMLMA
GWG
I
QRQ
Q
Y
GEQ
K
H
WMLVT
L
AA
ML
G
QI
G
T
P
GG
GF
G
FSYHYSNGGNP
T
R
V
G
GV----
-
-
LP
E
M
S
AAIAG
Q
A
S
-
-
-
--
E
A
A
D
D
G
G-
MTAI
PVARIV
D
ALENPGGKYQHN
GKE
QTYPN
IK
M
IW
-
W
AG
GGN
F
TH
H
Q
D
T
N
R
LIK
A
W
Q
-
-
-
K
P
EMIVV
S
E
C
YW
TA
A
AK
H
ADI
V
LP
ITT
SF
E
RN
DL
T
MTGD
YS
N
Q
-
H
I
V
PM
KQ
A
VA
P
Q
FE
ARNDFD
V
FADL
A
EL
L
K
P
GGKE
I
Y
TEG
K
D
E
MA
WLKF
F
Y
DAAQKG
AR
AQ
R
V
T
MP
M
F
N
A
F
W
QQ
NK
L
IEMR
R
S
E
K
NE
Q
YV
R
Y
A
D
FR
A
DP
V
K
N
A
L
G
TPSGKIEIYS
KT
L
E
K
FGYKDCPAH
P
TW
--
-
---
-
L
A
P
--
-
-
---
-
D
E
W
K
G
T
A
D
E
K
-
Q
LQL
L
TA
H
PA
H
R
L
HS
Q
LNYA
E
L
R
K
K
YAV
A
D
R
EPIT
I
HTE
DA
A
R
F
GIANGD
L
VRV
W
N
K
RG
Q
IL
TG
A
V
VT
DG
I
KK
GV
V
C
V
HE
GAW
P
D
L
E
-
-
-
N
G
L
CKN
GS
A
N
V
LTA
D
I
PS
SQ
LA
NACA
G
N
S
A
LV
Y
IEKYTGNAPKLTAFD
K
PAVQA
fig|573235.3.peg.2764
Escherichia coli O26:H11 str. 11368
MT
LT
RR
E
F
IK
H
S
G
I
AAG
AL
-
---
-
-
---
-
--
V
V
T
S
AAP
LP
AW
A
E
EK
-
--
G
G
K
I
LTA
G
RWG
A
MNVE
VKD
GK
I
-
---
V
S
STG
A
-
-
-
-
LAKTIPNS
L
QSTAADQVHTTA
RI
Q
HP
MVRKSY
L
D
N
P
LQPAKG
RGE
DTYVQV
SW
EQ
AL
KL
I
HEQ
H
D
RI
R
K
A
N
G
PS
A
I
F
--
-
-
AG
SY
G
WR
S
S
G
V
LHK
A
QT
L
LQ
R
Y
MN
LA
GG
Y
S
GH
S
G
D
YST
GAAQ
V
I
MP
H
VV
GS
VEVYEQQTSW
P
L
IL
ENS
Q
A
VV
LW
G
M
NP
LN
T
LKIAWSSTDEQ
GL
E
Y
F-
-
H
QLK
KS
GK
P
V
I
A
IDP
IR
S
E
T
IEFF
G
DNAT
W
IAPNM
GTD
V
AL
ML
GIA
HT
L
M
T
QG
K
H
D
KV
FL
E
KY
TT
GY
PQ
-----
-
--
-
-
-
-
FEE
Y
LT
G
KS
-
D
N
T
P
K
SA
A
WAAEITG
V
P
EA
QI
V
KLA
-
E
LM
AA
NRTMLMA
GWG
I
QRQ
Q
Y
GEQ
K
H
WMLVT
L
AA
ML
G
QI
G
T
P
GG
GF
G
FSYHYSNGGNP
T
R
V
G
GV----
-
-
LP
E
M
S
AAIAG
Q
A
S
-
-
-
--
E
A
A
D
D
G
G-
MTAI
PVARIV
D
ALENPGGKYQHN
GKE
QTYPN
IK
M
IW
-
W
AG
GGN
F
TH
H
Q
D
T
N
R
LIK
A
W
Q
-
-
-
K
P
EMIVV
S
E
C
YW
TA
A
AK
H
ADI
V
LP
ITT
SF
E
RN
DL
T
MTGD
YS
N
Q
-
H
I
V
PM
KQ
A
VA
P
Q
FE
ARNDFD
V
FADL
A
EL
L
K
P
GGKE
I
Y
TEG
K
D
E
MA
WLKF
F
Y
DAAQKG
AR
AQ
R
V
T
MP
M
F
N
A
F
W
QQ
NK
L
IEMR
R
S
E
K
NE
Q
YV
R
Y
A
D
FR
A
DP
V
K
N
A
L
G
TPSGKIEIYS
KT
L
E
K
FGYKDCPAH
P
TW
--
-
---
-
L
A
P
--
-
-
---
-
D
E
W
K
G
T
A
D
E
K
-
Q
LQL
L
TA
H
PA
H
R
L
HS
Q
LNYA
E
L
R
K
K
YAV
A
D
R
EPIT
I
HTE
DA
A
R
F
GIANGD
L
VRV
W
N
K
RG
Q
IL
TG
A
V
VT
DG
I
KK
GV
V
C
V
HE
GAW
P
D
L
E
-
-
-
N
G
L
CKN
GS
A
N
V
LTA
D
I
PS
SQ
LA
NACA
G
N
S
A
LV
Y
IEKYTGNAPKLTAFD
K
PAVQA
fig|550676.3.peg.2194
Escherichia coli B185
MT
LT
RR
E
F
IK
H
S
G
I
AAG
AL
-
---
-
-
---
-
--
V
V
T
S
AAP
LP
AW
A
E
EK
-
--
G
G
K
I
LTA
G
RWG
A
MNVE
VKD
GK
I
-
---
V
S
STG
A
-
-
-
-
LAKTIPNS
L
QSTAADQVHTTA
RI
Q
HP
MVRKSY
L
D
N
P
LQPAKG
RGE
DTYVQV
SW
EQ
AL
KL
I
HEQ
H
D
RI
R
K
A
N
G
PS
A
I
F
--
-
-
AG
SY
G
WR
S
S
G
V
LHK
A
QT
L
LQ
R
Y
MN
LA
GG
Y
S
GH
S
G
D
YST
GAAQ
V
I
MP
H
VV
GS
VEVYEQQTSW
P
L
IL
ENS
QV
VV
LW
G
M
NP
LN
T
LKIAWSSTDEQ
GL
E
Y
F-
-
H
QLK
KS
GK
P
V
I
A
IDP
IR
S
E
T
IEFF
G
DNAT
W
IAPNM
GTD
V
AL
ML
GIA
HT
L
M
T
QG
K
H
D
KV
FL
E
KY
TT
GY
PQ
-----
-
--
-
-
-
-
FEE
Y
LT
G
KS
-
D
N
T
P
K
SA
A
WAAEITG
V
P
EA
QI
V
KLA
-
E
LM
AA
NRTMLMA
GWG
I
QRQ
Q
Y
GEQ
K
H
WMLVT
L
AA
ML
G
QI
G
T
P
GG
GF
G
FSYHYSNGGNP
T
R
V
G
GV----
-
-
LP
E
M
S
AAIAG
Q
A
S
-
-
-
--
E
A
A
D
D
G
G-
MTAI
PVARIV
D
ALENPGGKYQHN
GKE
QTYPN
IK
M
IW
-
W
AG
GGN
F
TH
H
Q
D
T
N
R
LIK
A
W
Q
-
-
-
K
P
EMIVV
S
E
C
YW
TA
A
AK
H
ADI
V
LP
ITT
SF
E
RN
DL
T
MTGD
YS
N
Q
-
H
I
V
PM
KQ
A
VA
P
Q
FE
ARNDFD
V
FA
E
L
A
EL
L
K
P
GGKE
I
Y
TEG
K
D
E
MA
WLKF
F
Y
DAAQKG
AR
AQ
R
V
T
MP
M
F
N
A
F
W
QQ
NK
L
IEMR
R
S
E
K
NE
Q
YV
R
Y
G
D
FR
A
DP
V
K
N
A
L
G
TPSGKIEIYS
KT
L
E
K
FGYKDCPAH
P
TW
--
-
---
-
L
A
P
--
-
-
---
-
D
E
W
K
G
T
A
D
E
K
-
Q
LQL
L
TA
H
PA
H
R
L
HS
Q
LNYA
E
L
R
K
K
YAV
A
D
R
EPIT
I
HTE
DA
A
R
F
GIANGD
L
VRV
W
N
K
RG
Q
IL
TG
A
V
VT
DG
I
KK
GV
V
C
V
HE
GAW
P
D
L
E
-
-
-
N
G
L
CKN
GS
A
N
V
LTA
D
I
PS
SQ
LA
NACA
G
N
S
A
LV
Y
IEKYTGNAPKLTAFDQPAVQA
fig|749547.3.peg.1206
Escherichia coli MS 187-1
MT
LT
RR
E
F
IK
H
S
G
I
AAG
AL
-
---
-
-
---
-
--
V
V
T
S
AAP
LP
AW
A
E
EK
-
--
G
G
K
I
LTA
G
RWG
A
MNVE
VKD
GK
I
-
---
V
S
STG
A
-
-
-
-
LAKTIPNS
L
QSTAADQVHTTA
RI
Q
HP
MVRKSY
L
D
N
P
LQPAKG
RGE
DTYVQV
SW
EQ
AL
KL
I
HEQ
H
D
RI
R
K
A
N
G
PS
A
I
F
--
-
-
AG
SY
G
WR
S
S
G
V
LHK
A
QT
L
LQ
R
Y
MN
LA
GG
Y
S
GH
S
G
D
YST
GAAQ
V
I
MP
H
VV
GS
VEVYEQQTSW
P
L
IL
ENS
QV
VV
LW
G
M
NP
LN
T
LKIAWSSTDEQ
GL
E
Y
F-
-
H
QLK
KS
GK
P
V
I
A
IDP
IR
S
E
T
IEFF
G
DNAT
W
IAPNM
GTD
V
AL
ML
GIA
HT
L
M
T
QG
K
H
D
KV
FL
E
KY
TT
GY
PQ
-----
-
--
-
-
-
-
FEE
Y
LT
G
KS
-
D
N
T
P
K
SA
A
WAAEITG
V
P
EA
QI
V
KLA
-
E
LM
AA
NRTMLMA
GWG
I
QRQ
Q
Y
GEQ
K
H
WMLVT
L
AA
ML
G
QI
G
T
P
GG
GF
G
FSYHYSNGGNP
T
R
V
G
GV----
-
-
LP
E
M
S
AAIAG
Q
A
S
-
-
-
--
E
A
A
D
D
G
G-
MTAI
PVARIV
D
ALENPGGKYQHN
GKE
QTYPN
IK
M
IW
-
W
AG
GGN
F
TH
H
Q
D
T
N
R
LIK
A
W
Q
-
-
-
K
P
EMIVV
S
E
C
YW
TA
A
AK
H
ADI
V
LP
ITT
LF
E
RN
DL
T
MTGD
YS
N
Q
-
H
I
V
PM
KQ
A
VA
P
Q
FE
ARNDFD
V
FADL
A
EL
L
K
P
GGKE
I
Y
TEG
K
D
E
MA
WLKF
F
Y
DAAQKG
AR
AQ
R
V
T
MP
M
F
N
A
F
W
QQ
NK
L
IEMR
R
S
E
K
NE
Q
YV
R
Y
G
D
FR
A
DP
V
K
N
A
L
G
TPSGKIEIYS
KT
L
E
K
FGYKDCPAH
P
TW
--
-
---
-
L
A
P
--
-
-
---
-
D
E
W
K
G
T
A
D
E
K
-
Q
LQL
L
TA
H
PA
H
R
L
HS
Q
LNYA
E
L
R
K
K
YAV
A
D
R
EPIT
I
HTE
DA
A
R
F
GIANGD
L
VRV
W
N
K
RG
Q
IL
TG
A
V
VT
DG
I
KK
GV
V
C
V
HE
GAW
P
D
L
E
-
-
-
N
G
L
CKN
GS
A
N
V
LTA
D
I
PS
SQ
LA
NACA
G
N
S
A
LV
Y
IEKYTGNAPKLTAFDQPA
I
QA
fig|340186.3.peg.3088
Escherichia coli E110019
MT
LT
RR
E
F
IK
H
S
G
I
AAG
AL
-
---
-
-
---
-
--
V
V
T
S
AAP
LP
AW
A
E
EK
-
--
G
G
K
I
LTA
G
RWG
A
MNVE
VKD
GK
I
-
---
V
S
STG
A
-
-
-
-
LAKTIPNS
L
QSTAADQVHTT
T
RI
Q
HP
MVRKSY
L
D
N
P
LQP
T
KG
RGE
DTYVQV
SW
EQ
AL
KL
I
HEQ
H
D
RI
R
K
A
N
G
PS
A
I
F
--
-
-
AG
SY
G
WR
S
S
G
V
LHK
A
QT
L
LQ
R
Y
MN
LA
GG
Y
S
GH
S
G
D
YST
GAAQ
V
I
MP
H
VV
GS
VEVYEQQTSW
P
L
IL
ENS
QV
VV
LW
G
M
NP
LN
T
LKIAWSSTDEQ
GL
E
Y
F-
-
H
QLK
KS
GK
P
V
I
A
IDP
IR
S
E
T
IEFF
G
DNAT
W
IAPNM
GTD
V
AL
ML
GIA
HT
L
M
T
QG
K
H
D
KV
FL
E
KY
TT
GY
PQ
-----
-
--
-
-
-
-
FEE
Y
LT
G
KS
-
D
N
T
P
K
SA
A
WAAEITG
V
P
EA
QI
V
KLA
-
E
LM
AA
NRTMLMA
GWG
I
QRQ
Q
Y
GEQ
K
H
WMLVT
L
AA
ML
G
QI
G
T
P
GG
GF
G
FSYHYSNGGNP
T
R
V
G
GV----
-
-
LP
E
M
S
AAIAG
Q
A
S
-
-
-
--
E
A
A
D
D
G
G-
MTAI
PVARIV
D
ALENPGGKYQHN
GKE
QTYPN
IK
M
IW
-
W
AG
GGN
F
TH
H
Q
D
T
N
R
LIK
A
W
Q
-
-
-
K
P
EMIVV
S
E
C
YW
TA
A
AK
H
ADI
V
LP
ITT
SF
E
RN
DL
T
MTGD
YS
N
Q
-
H
I
V
PM
KQ
A
VA
P
Q
FE
ARNDFD
V
FADL
A
EL
L
K
P
GGKE
I
Y
TEG
K
D
E
MA
WLKF
F
Y
DAAQKG
AR
AQ
R
V
T
MP
M
F
N
A
F
W
QQ
NK
L
IEMR
R
S
E
K
NE
Q
YV
R
Y
G
D
FR
A
DP
V
K
N
A
L
G
TPSGKIEIYS
KT
L
E
K
FGYKDCPAH
P
TW
--
-
---
-
L
A
P
--
-
-
---
-
D
E
W
K
G
T
A
D
E
K
-
Q
LQL
L
TA
H
PA
H
R
L
HS
Q
LNYA
E
L
R
K
K
YAV
A
D
R
EPIT
I
HTE
DA
A
R
F
GIANGD
L
VRV
W
N
K
RG
Q
IL
TG
A
V
VT
DG
I
KK
GV
V
C
V
HE
GAW
P
D
L
E
-
-
-
N
G
L
CKN
GS
A
N
V
LTA
D
I
PS
SQ
LA
NACA
G
N
S
A
LV
Y
IEKYTGNAPKLTAFDQPA
I
QA
fig|340186.5.peg.3218
Escherichia coli E110019
MT
LT
RR
E
F
IK
H
S
G
I
AAG
AL
-
---
-
-
---
-
--
V
V
T
S
AAP
LP
AW
A
E
EK
-
--
G
G
K
I
LTA
G
RWG
A
MNVE
VKD
GK
I
-
---
V
S
STG
A
-
-
-
-
LAKTIPNS
L
QSTAADQVHTT
T
RI
Q
HP
MVRKSY
L
D
N
P
LQP
T
KG
RGE
DTYVQV
SW
EQ
AL
KL
I
HEQ
H
D
RI
R
K
A
N
G
PS
A
I
F
--
-
-
AG
SY
G
WR
S
S
G
V
LHK
A
QT
L
LQ
R
Y
MN
LA
GG
Y
S
GH
S
G
D
YST
GAAQ
V
I
MP
H
VV
GS
VEVYEQQTSW
P
L
IL
ENS
QV
VV
LW
G
M
NP
LN
T
LKIAWSSTDEQ
GL
E
Y
F-
-
H
QLK
KS
GK
P
V
I
A
IDP
IR
S
E
T
IEFF
G
DNAT
W
IAPNM
GTD
V
AL
ML
GIA
HT
L
M
T
QG
K
H
D
KV
FL
E
KY
TT
GY
PQ
-----
-
--
-
-
-
-
FEE
Y
LT
G
KS
-
D
N
T
P
K
SA
A
WAAEITG
V
P
EA
QI
V
KLA
-
E
LM
AA
NRTMLMA
GWG
I
QRQ
Q
Y
GEQ
K
H
WMLVT
L
AA
ML
G
QI
G
T
P
GG
GF
G
FSYHYSNGGNP
T
R
V
G
GV----
-
-
LP
E
M
S
AAIAG
Q
A
S
-
-
-
--
E
A
A
D
D
G
G-
MTAI
PVARIV
D
ALENPGGKYQHN
GKE
QTYPN
IK
M
IW
-
W
AG
GGN
F
TH
H
Q
D
T
N
R
LIK
A
W
Q
-
-
-
K
P
EMIVV
S
E
C
YW
TA
A
AK
H
ADI
V
LP
ITT
SF
E
RN
DL
T
MTGD
YS
N
Q
-
H
I
V
PM
KQ
A
VA
P
Q
FE
ARNDFD
V
FADL
A
EL
L
K
P
GGKE
I
Y
TEG
K
D
E
MA
WLKF
F
Y
DAAQKG
AR
AQ
R
V
T
MP
M
F
N
A
F
W
QQ
NK
L
IEMR
R
S
E
K
NE
Q
YV
R
Y
G
D
FR
A
DP
V
K
N
A
L
G
TPSGKIEIYS
KT
L
E
K
FGYKDCPAH
P
TW
--
-
---
-
L
A
P
--
-
-
---
-
D
E
W
K
G
T
A
D
E
K
-
Q
LQL
L
TA
H
PA
H
R
L
HS
Q
LNYA
E
L
R
K
K
YAV
A
D
R
EPIT
I
HTE
DA
A
R
F
GIANGD
L
VRV
W
N
K
RG
Q
IL
TG
A
V
VT
DG
I
KK
GV
V
C
V
HE
GAW
P
D
L
E
-
-
-
N
G
L
CKN
GS
A
N
V
LTA
D
I
PS
SQ
LA
NACA
G
N
S
A
LV
Y
IEKYTGNAPKLTAFDQPA
I
QA
fig|358709.5.peg.3773
Escherichia coli 101-1
MT
LT
RR
E
F
IK
H
S
G
I
AAG
AL
-
---
-
-
---
-
--
V
V
T
S
AAP
LP
AW
A
E
EK
-
--
G
G
K
I
LTA
G
RWG
A
MNVE
VKD
GK
I
-
---
V
S
STG
A
-
-
-
-
LAKTIPNS
L
QSTAADQVHTTA
RI
Q
HP
MVRKSY
L
D
N
P
LQPAKG
RGE
DTYVQV
SW
EQ
AL
KL
I
YEQ
H
D
RI
R
K
A
N
G
PS
A
I
F
--
-
-
AG
SY
G
WR
S
S
G
V
LHK
A
QT
L
LQ
R
Y
MN
LA
GG
Y
S
GH
S
G
D
YST
GAAQ
V
I
MP
H
VV
GS
VEVYEQQTSW
P
L
IL
ENS
QV
VV
LW
G
M
NP
LN
T
LKIAWSSTDEQ
GL
E
Y
F-
-
H
QLK
KS
GK
P
V
I
A
IDP
IR
S
E
T
IEFF
G
DNAT
W
IAPNM
GTD
V
AL
ML
GIA
HT
L
M
T
QG
K
H
D
KV
FL
E
KY
TT
GY
PQ
-----
-
--
-
-
-
-
FEE
Y
LT
G
KS
-
D
N
T
P
K
SA
A
WAAEITG
V
P
EA
QI
V
KLA
-
E
LM
AA
NRTMLMA
GWG
I
QRQ
Q
Y
GEQ
K
H
WMLVT
L
AA
ML
G
QI
G
T
P
GG
GF
G
FSYHYSNGGNP
T
R
V
G
GV----
-
-
LP
E
M
S
AAIAG
Q
A
S
-
-
-
--
E
A
A
D
D
G
G-
MTAI
PVARIV
D
ALENPGGKYQHN
GKE
QTYPN
IK
M
IW
-
W
AG
GGN
F
TH
H
Q
D
T
N
R
LIK
A
W
Q
-
-
-
K
P
EMIVV
S
E
C
YW
TA
A
AK
H
ADI
V
LP
ITT
SF
E
RN
DL
T
MTGD
YS
N
Q
-
H
I
V
PM
KQVVA
P
Q
FE
ARNDFD
V
FADL
A
EL
L
K
P
GGKE
I
Y
TEG
K
D
E
MA
WLKF
F
Y
DAAQKG
AR
AQ
R
V
T
MP
M
F
N
A
F
W
QQ
NK
L
IEMR
R
S
E
K
NE
Q
YV
R
Y
G
D
FR
A
DP
V
K
N
A
L
G
TPSGKIEIYS
KT
L
E
K
FGYKDCPAH
P
TW
--
-
---
-
L
A
P
--
-
-
---
-
D
E
W
K
G
T
A
D
E
K
-
Q
LQL
L
TA
H
PA
H
R
L
HS
Q
LNYA
E
L
R
K
K
YAV
A
D
R
EPIT
I
HTE
DA
A
R
F
GIANGD
L
VRV
W
N
K
RG
Q
IL
TG
A
V
VT
DG
I
KK
GV
V
C
V
HE
GAW
P
D
L
E
-
-
-
N
G
L
CKN
GS
A
N
V
LTA
D
I
PS
SQ
LA
NACA
G
N
S
A
LV
Y
IEKYTGNAPKLTAFDQPA
I
QA
fig|656419.3.peg.2603
Escherichia coli M718
MT
LT
RR
E
F
IK
H
S
G
I
AAG
AL
-
---
-
-
---
-
--
V
V
T
S
AAP
LP
AW
A
E
EK
-
--
G
G
K
I
LTA
G
RWG
A
MNVE
VKD
GK
I
-
---
V
S
STG
A
-
-
-
-
LAKTIPNS
L
QSTAADQVHTTA
RI
Q
HP
MVRKSY
L
D
N
P
LQPAKG
RGE
DTYVQV
SW
EQ
AL
KL
I
HEQ
H
E
RI
R
K
A
N
G
Q
S
A
I
F
--
-
-
AG
SY
G
WR
S
S
G
V
LHK
A
QT
L
LQ
R
Y
MN
LA
GG
Y
S
GH
S
G
D
YST
GAAQ
V
I
MP
H
VV
GS
VEVYEQQTSW
P
L
IL
ENS
QV
VV
LW
G
M
NP
LN
T
LKIAWSSTDEQ
GL
E
Y
F-
-
H
QLK
KS
GK
P
V
I
A
IDP
IR
S
E
T
IEFF
G
DN
V
T
W
IAPNM
GTD
V
AL
ML
GIA
HT
L
M
T
QG
K
H
D
KV
FL
E
KY
TT
GY
PQ
-----
-
--
-
-
-
-
FEE
Y
LT
G
KS
-
D
N
T
P
K
SA
A
WAAEITG
V
P
EA
QI
V
KLA
-
E
LM
AA
NRTMLMA
GWG
I
QRQ
Q
Y
GEQ
K
H
WMLVT
L
AA
ML
G
QI
G
T
P
GG
GF
G
FSYHYSNGGNP
T
R
V
G
GV----
-
-
LP
E
M
S
AAIAG
Q
A
S
-
-
-
--
E
A
A
D
D
G
G-
MTAI
PVARIV
D
ALENPGGKYQHN
GKE
QTYPN
IK
M
IW
-
W
AG
GGN
F
TH
H
Q
D
T
N
R
LIK
A
W
Q
-
-
-
K
P
EMIVV
S
E
C
YW
TA
A
AK
H
ADI
V
LP
ITT
SF
E
RN
DL
T
MTGD
YS
N
Q
-
H
I
V
PM
KQ
A
VA
P
Q
FE
ARNDFD
V
FADL
A
EL
L
K
P
GGKE
I
Y
TEG
K
D
E
MA
WLKF
F
Y
DAAQKG
AR
AQ
R
V
T
MP
M
F
N
A
F
W
QQ
NK
L
IEMR
R
S
E
K
NE
Q
YV
R
Y
G
D
FR
A
DP
V
K
N
A
L
G
TPSGKIEIYS
KT
L
E
K
FGYKDCPAH
P
TW
--
-
---
-
L
A
P
--
-
-
---
-
D
E
W
K
G
T
A
D
E
K
-
Q
LQL
L
TA
H
PA
H
R
L
HS
Q
LNYA
E
L
R
K
K
YAV
A
D
R
EPIT
I
HTE
DA
A
R
F
GIANGD
L
VRV
W
N
K
RG
Q
IL
TG
A
V
VT
DG
I
KK
GV
V
C
V
HE
GAW
P
D
L
E
-
-
-
N
G
L
CKN
GS
A
N
V
LTA
D
I
PS
SQ
LA
NACA
G
N
S
A
LV
Y
IEKYTGNAPKLTAFDQPAVQA
fig|656443.3.peg.2562
Escherichia coli TA271
MT
LT
RR
E
F
IK
H
S
G
I
AAG
AL
-
---
-
-
---
-
--
V
V
T
S
AAP
LP
AW
A
E
EK
-
--
G
G
K
I
LTA
G
RWG
A
M
S
VE
VKD
GK
I
-
---
V
S
STG
A
-
-
-
-
LAKTIPNS
L
QSTAADQVHTTA
RI
Q
HP
MVRKSY
L
D
N
P
LQPAKG
RGE
DTYVQV
SW
EQ
AL
KL
I
HEQ
H
D
RI
R
K
A
N
G
PS
A
I
F
--
-
-
AG
SY
G
WR
S
S
G
V
LHK
A
QT
L
LQ
R
Y
MN
LA
GG
Y
S
GH
S
G
D
YST
GAAQ
V
I
MP
H
VV
GS
VEVYEQQTSW
P
L
IL
ENS
Q
A
VV
LW
G
M
NP
LN
T
LKIAWSSTDEQ
GL
E
Y
F-
-
H
QLK
KS
GK
P
V
I
A
IDP
IR
S
E
T
IEFF
G
DNAT
W
IAPNM
GTD
V
AL
ML
GIA
HT
L
M
T
QG
K
H
D
KV
FL
E
KY
TT
GY
PQ
-----
-
--
-
-
-
-
FEE
Y
LT
G
KS
-
D
N
T
P
K
SA
A
WAAEITG
V
P
EA
QI
V
KLA
-
E
LM
AA
NRTMLMA
GWG
I
QRQ
Q
Y
GEQ
K
H
WMLVT
L
AA
ML
G
QI
G
T
P
GG
GF
G
FSYHYSNGGNP
T
R
V
G
GV----
-
-
LP
E
M
S
AAIAG
Q
A
S
-
-
-
--
E
A
A
D
D
G
G-
MTAI
PVARIV
D
ALENPGGKYQHN
GKE
QTYPN
IK
M
IW
-
W
AG
GGN
F
TH
H
Q
D
T
N
R
LIK
A
W
Q
-
-
-
K
P
EMIVV
S
E
C
YW
TA
A
AK
H
ADI
V
LP
ITT
SF
E
RN
DL
T
MTGD
YS
N
Q
-
H
I
V
PM
KQ
A
VA
P
Q
FE
ARNDFD
V
FADL
A
EL
L
K
P
GGKE
I
Y
TEG
K
D
E
MA
WLKF
F
Y
DAAQKG
AR
AQ
R
V
T
MP
M
F
N
A
F
W
QQ
NK
L
IEMR
R
S
E
K
NE
Q
YV
R
Y
A
D
FR
A
DP
V
K
N
A
L
G
TPSGKIEIYS
KT
L
E
KI
GYKDCPAH
P
TW
--
-
---
-
L
A
P
--
-
-
---
-
D
E
W
K
G
T
A
D
E
K
-
Q
LQL
L
TA
H
PA
H
R
L
HS
Q
LNYA
E
L
R
K
K
YAV
A
D
R
EPIT
I
HTE
DA
A
R
F
GIANGD
L
VRV
W
N
K
RG
Q
IL
TG
A
V
VT
DG
I
KK
GV
V
C
V
HE
GAW
P
D
L
E
-
-
-
N
G
L
CKN
GS
A
N
V
LTA
D
I
PS
SQ
LA
NACA
G
N
S
A
LV
Y
IEKYTGNAPKLTAFDQPA
I
QA
fig|550677.3.peg.1363
Escherichia coli B354
MT
LT
RR
E
F
IK
H
S
G
I
AAG
AL
-
---
-
-
---
-
--
V
V
T
S
A
T
P
LP
AW
A
E
EK
-
--
G
G
K
I
LTA
G
RWG
A
MNVE
VKD
GK
I
-
---
V
S
STG
A
-
-
-
-
LAKTIPNS
L
QSTAADQVHTTA
RI
Q
HP
MVRKSY
L
D
N
P
LQPAKG
RGE
DTYVQV
SW
EQ
AL
KL
I
HEQ
H
D
RI
R
K
A
N
G
PS
A
I
F
--
-
-
AG
SY
G
WR
S
S
G
V
LHK
A
QT
L
LQ
R
Y
MN
LA
GG
Y
S
GH
S
G
D
YST
GAAQ
V
I
MP
H
VV
GS
VEVYEQQTSW
P
L
IL
ENS
QV
VV
LW
G
M
NP
LN
T
LKIAWSSTDEQ
GL
E
Y
F-
-
H
QLK
KS
GK
P
V
I
A
IDP
IR
S
E
T
IEFF
G
DNAT
W
IAPNM
GTD
V
AL
ML
GIA
HT
L
M
T
QG
K
H
D
KV
FL
E
KY
TT
GY
PQ
-----
-
--
-
-
-
-
FEE
Y
LT
G
KS
-
D
N
T
P
K
SA
A
WAAEITG
V
P
EA
QI
V
KLA
-
E
LM
AA
NRTMLMA
GWG
I
QRQ
Q
Y
GEQ
K
H
WMLVT
L
AA
ML
G
QI
G
T
P
GG
GF
G
FSYHYSNGGNP
T
R
V
G
GV----
-
-
LP
E
M
S
AAIAG
Q
A
S
-
-
-
--
E
A
A
D
D
G
G-
MTAI
PVARIV
D
ALENPGGKYQHN
GKE
QTYPN
IK
M
IW
-
W
AG
GGN
F
TH
H
Q
D
T
N
R
LIK
A
W
Q
-
-
-
K
P
EMIVV
S
E
C
YW
TA
A
AK
H
ADI
V
LP
ITT
SF
E
RN
DL
T
MTGD
YS
N
Q
-
H
I
V
PM
KQ
A
VA
P
Q
FE
ARNDFD
V
FADL
A
EL
L
K
P
GGKE
I
Y
TEG
K
D
E
MA
WLKF
F
Y
DAAQKG
AR
AQ
R
V
T
MP
M
F
N
A
F
W
QQ
NK
L
IEMR
R
S
E
K
NE
Q
YV
R
Y
G
D
FR
A
DP
V
K
N
A
L
G
TPSGKIEIYS
KT
L
E
K
FGYKDCPAH
P
TW
--
-
---
-
L
A
P
--
-
-
---
-
D
E
W
K
G
S
A
D
E
K
-
Q
LQL
L
TA
H
PA
H
R
L
HS
Q
LNYA
E
L
R
K
K
YAV
A
D
R
EPIT
I
HT
K
DA
A
R
F
GIANGD
L
VRV
W
N
K
RG
Q
IL
TG
A
V
VT
DG
I
KK
GV
V
C
V
HE
GAW
P
D
L
E
-
-
-
N
G
L
CKN
GS
A
N
V
LTA
D
I
PS
SQ
LA
NACA
G
N
S
A
LV
Y
IEKYTGNAPKLTAFDQPAVQA
fig|216592.1.peg.1434
Escherichia coli 042 (7-815/815)
MT
LT
RR
E
F
IK
H
S
G
I
AAG
AL
-
---
-
-
---
-
--
V
V
T
S
AAP
LP
AW
A
E
EK
-
--
G
G
K
I
LTA
G
RWG
A
MNVE
VKD
GK
I
-
---
V
S
STG
A
-
-
-
-
LAKTIPNS
L
QSTAADQVHTTA
RI
Q
HP
MVRKSY
F
D
N
P
LQPAKG
RGE
DTYVQV
SW
EQ
AL
KL
I
HEQ
H
D
RI
R
K
A
N
G
PS
A
I
F
--
-
-
AG
SY
G
WR
S
S
G
V
LHK
A
QT
L
LQ
R
Y
MN
LA
GG
Y
S
GH
S
G
D
YST
GAAQ
V
I
MP
H
VV
GS
VEVYEQQTSW
P
L
IL
ENS
QV
VV
LW
G
M
NP
LN
T
LKIAWSSTDEQ
GL
E
Y
F-
-
H
QLK
KS
GK
P
V
I
A
IDP
IR
S
E
T
IEFF
G
DNAT
W
IAPNM
GTD
V
AL
ML
GIA
HT
L
M
T
QG
K
H
D
KV
FL
E
KY
TT
GY
PQ
-----
-
--
-
-
-
-
FEE
Y
LT
G
KS
-
D
N
T
P
K
SA
A
WAAEITG
V
P
EA
QI
V
KLA
-
E
LM
AA
NRTMLMA
GWG
I
QRQ
Q
Y
GEQ
K
H
WMLVT
L
AA
ML
G
QI
G
T
P
GG
GF
G
FSYHYSNGGNP
T
R
V
G
GV----
-
-
LP
E
M
S
AAIAG
Q
A
S
-
-
-
--
E
A
A
D
D
G
G-
MTAI
PVARIV
D
ALENPGGKYQHN
GKE
QTYPN
IK
M
IW
-
W
AG
GGN
F
TH
H
Q
D
T
N
R
LIK
A
W
Q
-
-
-
K
P
EMIVV
S
E
C
YW
TA
A
AK
H
ADI
V
LP
ITT
SF
E
RN
DL
T
MTGD
YS
N
Q
-
H
I
V
PM
KQ
A
VA
A
Q
FE
ARNDFD
V
FADL
A
EL
L
K
P
GGKE
I
Y
TEG
K
D
E
MA
WLKF
F
Y
DAAQKG
AR
AQ
R
V
T
MP
M
F
N
A
F
W
QQ
NK
L
IEMR
R
S
E
K
NE
Q
YV
R
Y
G
D
FR
A
DP
V
K
N
A
L
G
TPSGKIEIYS
KT
L
E
K
FGYKDCPAH
P
TW
--
-
---
-
L
A
P
--
-
-
---
-
D
E
W
K
G
T
A
D
E
K
-
Q
LQL
L
TA
H
PA
H
R
L
HS
Q
LNYA
E
L
R
K
K
YAV
A
D
R
EPIT
I
HTE
DA
A
R
F
GIANGD
L
VRV
W
N
K
RG
Q
IL
TG
A
V
VT
DG
I
KK
GV
V
C
V
HE
GAW
P
D
L
E
-
-
-
N
G
L
CKN
GS
A
N
V
LTA
D
I
PS
SQ
LA
NACA
G
N
S
A
LV
Y
IEKYTGNAPKLTAFDQPAVQA
fig|216592.3.peg.2121
Escherichia coli 042
MT
LT
RR
E
F
IK
H
S
G
I
AAG
AL
-
---
-
-
---
-
--
V
V
T
S
AAP
LP
AW
A
E
EK
-
--
G
G
K
I
LTA
G
RWG
A
MNVE
VKD
GK
I
-
---
V
S
STG
A
-
-
-
-
LAKTIPNS
L
QSTAADQVHTTA
RI
Q
HP
MVRKSY
F
D
N
P
LQPAKG
RGE
DTYVQV
SW
EQ
AL
KL
I
HEQ
H
D
RI
R
K
A
N
G
PS
A
I
F
--
-
-
AG
SY
G
WR
S
S
G
V
LHK
A
QT
L
LQ
R
Y
MN
LA
GG
Y
S
GH
S
G
D
YST
GAAQ
V
I
MP
H
VV
GS
VEVYEQQTSW
P
L
IL
ENS
QV
VV
LW
G
M
NP
LN
T
LKIAWSSTDEQ
GL
E
Y
F-
-
H
QLK
KS
GK
P
V
I
A
IDP
IR
S
E
T
IEFF
G
DNAT
W
IAPNM
GTD
V
AL
ML
GIA
HT
L
M
T
QG
K
H
D
KV
FL
E
KY
TT
GY
PQ
-----
-
--
-
-
-
-
FEE
Y
LT
G
KS
-
D
N
T
P
K
SA
A
WAAEITG
V
P
EA
QI
V
KLA
-
E
LM
AA
NRTMLMA
GWG
I
QRQ
Q
Y
GEQ
K
H
WMLVT
L
AA
ML
G
QI
G
T
P
GG
GF
G
FSYHYSNGGNP
T
R
V
G
GV----
-
-
LP
E
M
S
AAIAG
Q
A
S
-
-
-
--
E
A
A
D
D
G
G-
MTAI
PVARIV
D
ALENPGGKYQHN
GKE
QTYPN
IK
M
IW
-
W
AG
GGN
F
TH
H
Q
D
T
N
R
LIK
A
W
Q
-
-
-
K
P
EMIVV
S
E
C
YW
TA
A
AK
H
ADI
V
LP
ITT
SF
E
RN
DL
T
MTGD
YS
N
Q
-
H
I
V
PM
KQ
A
VA
A
Q
FE
ARNDFD
V
FADL
A
EL
L
K
P
GGKE
I
Y
TEG
K
D
E
MA
WLKF
F
Y
DAAQKG
AR
AQ
R
V
T
MP
M
F
N
A
F
W
QQ
NK
L
IEMR
R
S
E
K
NE
Q
YV
R
Y
G
D
FR
A
DP
V
K
N
A
L
G
TPSGKIEIYS
KT
L
E
K
FGYKDCPAH
P
TW
--
-
---
-
L
A
P
--
-
-
---
-
D
E
W
K
G
T
A
D
E
K
-
Q
LQL
L
TA
H
PA
H
R
L
HS
Q
LNYA
E
L
R
K
K
YAV
A
D
R
EPIT
I
HTE
DA
A
R
F
GIANGD
L
VRV
W
N
K
RG
Q
IL
TG
A
V
VT
DG
I
KK
GV
V
C
V
HE
GAW
P
D
L
E
-
-
-
N
G
L
CKN
GS
A
N
V
LTA
D
I
PS
SQ
LA
NACA
G
N
S
A
LV
Y
IEKYTGNAPKLTAFDQPAVQA
fig|656393.3.peg.2679
Escherichia coli H299
MT
LT
RR
E
F
IK
H
S
G
I
AAG
AL
-
---
-
-
---
-
--
V
V
T
S
AAP
LP
AW
A
E
EK
-
--
G
G
K
I
LTA
G
RWG
A
MNVE
VKD
GK
I
-
---
V
S
STG
A
-
-
-
-
LAKTIPNS
L
QSTAADQVHTTA
RI
Q
HP
MVRKSY
L
D
N
P
LQPAKG
RGE
DTYVQV
SW
EQ
AL
KL
I
HEQ
H
D
RI
R
K
A
N
G
PS
A
I
F
--
-
-
AG
SY
G
WR
S
S
G
V
LHK
A
QT
L
LQ
R
Y
MN
LA
GG
Y
S
GH
S
G
D
YST
GAAQ
V
I
MP
H
VV
GS
VEVYEQQTSW
P
L
IL
ENS
QV
VV
LW
G
M
NP
LN
T
LKIAWSSTDEQ
GL
E
Y
F-
-
H
QLK
KS
GK
P
V
I
A
IDP
I
C
S
E
T
IEFF
G
DNAT
W
IAPNM
GTD
V
AL
ML
GIA
HT
L
M
T
QG
K
H
D
KV
FL
E
KY
TT
GY
PQ
-----
-
--
-
-
-
-
FEE
Y
LT
G
KS
-
D
N
T
P
K
SA
A
WAAEITG
V
P
EA
QI
V
KLA
-
E
LM
AA
NRTMLMA
GWG
I
QRQ
Q
Y
GEQ
K
H
WMLVT
L
AA
ML
G
QI
G
T
P
GG
GF
G
FSYHYSNGGNP
T
R
V
G
GV----
-
-
LP
E
M
S
AAIAG
Q
A
S
-
-
-
--
E
A
A
D
D
G
G-
MTAI
PVARIV
D
ALENPGGKYQHN
GKE
QTYPN
IK
M
IW
-
W
AG
GGN
F
TH
H
Q
D
T
N
R
LIK
A
W
Q
-
-
-
K
P
EMIVV
S
E
C
YW
TA
A
AK
H
ADI
V
LP
ITT
SF
E
RN
DL
T
MTGD
YS
N
Q
-
H
I
V
PM
KQ
A
VA
P
Q
FE
ARNDFD
V
FADL
A
EL
L
K
P
GGKE
I
Y
TEG
K
D
E
MA
WLKF
F
Y
DAAQKG
AR
AQ
R
V
T
MP
M
F
N
A
F
W
QQ
NK
L
IEMR
R
S
E
K
NE
Q
YV
R
Y
G
D
FR
A
DP
V
K
N
A
L
G
TPSGKIEIYS
KT
L
E
K
FGYKDCPAH
P
TW
--
-
---
-
L
A
P
--
-
-
---
-
D
E
W
K
G
S
A
D
E
K
-
Q
LQL
L
TA
H
PA
H
R
L
HS
Q
LNYA
E
L
R
K
K
YAV
A
D
R
EPIT
I
HTE
DA
A
R
F
GIANGD
L
VRV
W
N
K
RG
Q
IL
TG
A
V
VT
DG
I
KK
GV
V
C
V
HE
GAW
P
D
L
E
-
-
-
N
G
L
CKN
GS
A
N
V
LTA
D
I
PS
SQ
LA
NACA
G
N
S
A
LV
Y
IEKYTGNAPKLTAFDQPAVQA
fig|585034.4.peg.1936
Escherichia coli IAI1
MT
LT
RR
E
F
IK
H
S
G
I
AAG
AL
-
---
-
-
---
-
--
V
V
T
S
AAP
LP
AW
A
E
EK
-
--
G
G
K
I
LTA
G
RWG
A
MNVE
VKD
GK
I
-
---
V
S
STG
A
-
-
-
-
LAKTIPNS
L
QSTAADQVHTTA
RI
Q
HP
MVRKSY
L
D
N
P
LQPAKG
RGE
DTYVQV
SW
EQ
AL
KL
I
HEQ
H
D
RI
R
K
A
N
G
PS
A
I
F
--
-
-
AG
SY
G
WR
S
S
G
V
LHK
A
QT
L
LQ
R
Y
MN
LA
GG
Y
S
GH
S
G
D
YST
GAAQ
V
I
MP
H
VV
GS
VEVYEQQTSW
P
L
IL
ENS
Q
A
VV
LW
G
M
NP
LN
T
LKIAWSSTDEQ
GL
E
Y
F-
-
H
QLK
KS
GK
P
V
I
A
IDP
IR
S
E
T
IEFF
G
DNAT
W
IAPNM
GTD
V
AL
ML
GIA
HT
L
M
T
QG
K
H
D
KV
FL
E
KY
TT
GY
PQ
-----
-
--
-
-
-
-
FEE
Y
LT
G
KS
-
D
N
T
P
K
SA
A
WAAEITG
V
P
EA
QI
V
KLA
-
E
LM
AA
NRTMLMA
GWG
I
QRQ
Q
Y
GEQ
K
H
WMLVT
L
AA
ML
G
QI
G
T
P
GG
GF
G
FSYHYSNGGNP
T
R
V
G
GV----
-
-
LP
E
M
S
AAIAG
Q
A
S
-
-
-
--
E
A
A
D
D
G
G-
MTAI
PVARIV
D
ALENPGGKYQHN
GKE
QTYPN
IK
M
IW
-
W
AG
GGN
F
TH
H
Q
D
T
N
R
LIK
A
W
Q
-
-
-
K
P
EMIVV
S
E
C
YW
TA
A
AK
H
ADI
V
LP
ITT
SF
E
RN
DL
T
MTGD
YS
N
Q
-
H
I
V
PM
KQ
A
VA
P
Q
FE
ARNDFD
V
FADL
A
EL
L
K
P
GGKE
I
Y
TEG
K
D
E
MA
WLKF
F
Y
DAAQKG
AR
AQ
R
V
T
MP
M
F
N
V
F
W
QQ
NK
L
IEMR
R
S
E
K
NE
Q
YV
R
Y
G
D
FR
A
DP
V
K
N
A
L
G
TPSGKIEIYS
KT
L
E
K
FGYKDCPAH
P
TW
--
-
---
-
L
A
P
--
-
-
---
-
D
E
W
K
G
T
A
D
E
K
-
Q
LQL
L
TA
H
PA
H
R
L
HS
Q
LNYA
E
L
R
K
K
YAV
A
D
R
EPIT
I
HTE
DA
A
R
F
GIANGD
L
VRV
W
N
K
RG
Q
IL
TG
A
V
VT
DG
I
KK
GV
V
C
V
HE
GAW
P
D
L
E
-
-
-
N
G
L
CKN
GS
A
N
V
LTA
D
I
PS
SQ
LA
NACA
G
N
S
A
LV
Y
IEKYTGNAPKLTAFD
K
PAVQA
fig|585034.5.peg.1931
Escherichia coli IAI1
MT
LT
RR
E
F
IK
H
S
G
I
AAG
AL
-
---
-
-
---
-
--
V
V
T
S
AAP
LP
AW
A
E
EK
-
--
G
G
K
I
LTA
G
RWG
A
MNVE
VKD
GK
I
-
---
V
S
STG
A
-
-
-
-
LAKTIPNS
L
QSTAADQVHTTA
RI
Q
HP
MVRKSY
L
D
N
P
LQPAKG
RGE
DTYVQV
SW
EQ
AL
KL
I
HEQ
H
D
RI
R
K
A
N
G
PS
A
I
F
--
-
-
AG
SY
G
WR
S
S
G
V
LHK
A
QT
L
LQ
R
Y
MN
LA
GG
Y
S
GH
S
G
D
YST
GAAQ
V
I
MP
H
VV
GS
VEVYEQQTSW
P
L
IL
ENS
Q
A
VV
LW
G
M
NP
LN
T
LKIAWSSTDEQ
GL
E
Y
F-
-
H
QLK
KS
GK
P
V
I
A
IDP
IR
S
E
T
IEFF
G
DNAT
W
IAPNM
GTD
V
AL
ML
GIA
HT
L
M
T
QG
K
H
D
KV
FL
E
KY
TT
GY
PQ
-----
-
--
-
-
-
-
FEE
Y
LT
G
KS
-
D
N
T
P
K
SA
A
WAAEITG
V
P
EA
QI
V
KLA
-
E
LM
AA
NRTMLMA
GWG
I
QRQ
Q
Y
GEQ
K
H
WMLVT
L
AA
ML
G
QI
G
T
P
GG
GF
G
FSYHYSNGGNP
T
R
V
G
GV----
-
-
LP
E
M
S
AAIAG
Q
A
S
-
-
-
--
E
A
A
D
D
G
G-
MTAI
PVARIV
D
ALENPGGKYQHN
GKE
QTYPN
IK
M
IW
-
W
AG
GGN
F
TH
H
Q
D
T
N
R
LIK
A
W
Q
-
-
-
K
P
EMIVV
S
E
C
YW
TA
A
AK
H
ADI
V
LP
ITT
SF
E
RN
DL
T
MTGD
YS
N
Q
-
H
I
V
PM
KQ
A
VA
P
Q
FE
ARNDFD
V
FADL
A
EL
L
K
P
GGKE
I
Y
TEG
K
D
E
MA
WLKF
F
Y
DAAQKG
AR
AQ
R
V
T
MP
M
F
N
V
F
W
QQ
NK
L
IEMR
R
S
E
K
NE
Q
YV
R
Y
G
D
FR
A
DP
V
K
N
A
L
G
TPSGKIEIYS
KT
L
E
K
FGYKDCPAH
P
TW
--
-
---
-
L
A
P
--
-
-
---
-
D
E
W
K
G
T
A
D
E
K
-
Q
LQL
L
TA
H
PA
H
R
L
HS
Q
LNYA
E
L
R
K
K
YAV
A
D
R
EPIT
I
HTE
DA
A
R
F
GIANGD
L
VRV
W
N
K
RG
Q
IL
TG
A
V
VT
DG
I
KK
GV
V
C
V
HE
GAW
P
D
L
E
-
-
-
N
G
L
CKN
GS
A
N
V
LTA
D
I
PS
SQ
LA
NACA
G
N
S
A
LV
Y
IEKYTGNAPKLTAFD
K
PAVQA
fig|679204.3.peg.3144
Escherichia coli MS 145-7
MT
LT
RR
E
F
IK
H
S
G
I
AAG
AL
-
---
-
-
---
-
--
V
V
T
S
AAP
LP
AW
A
E
EK
-
--
G
G
K
I
LTA
G
RWG
A
MNVE
VKD
GK
I
-
---
V
S
STG
A
-
-
-
-
LAKTIPNS
L
QSTAADQVHTTA
RI
Q
HP
MVRKSY
L
D
N
P
LQPAKG
RGE
DTYVQV
SW
EQ
AL
KL
I
HEQ
H
D
RI
R
K
A
N
G
PS
A
I
F
--
-
-
AG
SY
G
WR
S
S
G
V
LHK
A
QT
L
LQ
R
Y
MN
LA
GG
Y
S
GH
S
G
D
YST
GAAQ
V
I
MP
H
VV
GS
VEVYEQQTSW
P
L
IL
ENS
Q
A
VV
LW
G
M
NP
LN
T
LKIAWSSTDEQ
GL
E
Y
F-
-
H
QLK
KS
GK
P
V
I
A
IDP
IR
S
E
T
IEFF
G
DNAT
W
IAPNM
GTD
V
AL
ML
GIA
HT
L
M
T
QG
K
H
D
KV
FL
E
KY
TT
GY
PQ
-----
-
--
-
-
-
-
FEE
Y
LT
G
KS
-
D
N
T
P
K
SA
A
WAAEITG
V
P
EA
QI
V
KLA
-
E
LM
AA
NRTMLMA
GWG
I
QRQ
Q
Y
GEQ
K
H
WMLVT
L
AA
ML
G
QI
G
T
P
GG
GF
G
FSYHYSNGGNP
T
R
V
G
GV----
-
-
LP
E
M
S
AAIAG
Q
A
S
-
-
-
--
E
A
A
D
D
G
G-
MTAI
PVARIV
D
ALENPGGKYQHN
GKE
QTYPN
IK
M
IW
-
W
AG
GGN
F
TH
H
Q
D
T
N
R
LIK
A
W
Q
-
-
-
K
P
EMIVV
S
E
C
YW
TA
A
AK
H
ADI
V
LP
ITT
SF
E
RN
DL
T
MTGD
YS
N
Q
-
H
I
V
PM
KQ
A
VA
P
Q
FE
ARNDFD
V
FADL
A
EL
L
K
P
GGKE
I
Y
TEG
K
D
E
MA
WLKF
F
Y
Y
AAQKG
AR
AQ
R
V
T
MP
M
F
N
A
F
W
QQ
NK
L
IEMR
R
S
E
K
NE
Q
YV
R
Y
A
D
FR
A
DP
V
K
N
A
L
G
TPSGKIEIYS
KT
L
E
K
FGYKDCPAH
P
TW
--
-
---
-
L
A
P
--
-
-
---
-
D
E
W
K
G
T
A
D
E
K
-
Q
LQL
L
TA
H
PA
H
R
L
HS
Q
LNYA
E
L
R
K
K
YAV
A
D
R
EPIT
I
HTE
DA
A
R
F
GIANGD
L
VRV
W
N
K
RG
Q
IL
TG
A
V
VT
DG
I
KK
GV
V
C
V
HE
GAW
P
D
L
E
-
-
-
N
G
L
CKN
GS
A
N
V
LTA
D
I
PS
SQ
LA
NACA
G
N
S
A
LV
Y
IEKYTGNAPKLTAFD
K
PAVQA
fig|585396.4.peg.2548
Escherichia coli O111:H- str. 11128
MT
LT
RR
E
F
IK
H
S
G
I
AAG
AL
-
---
-
-
---
-
--
V
V
T
S
AAP
LP
AW
A
E
EK
-
--
G
G
K
I
LTA
G
RWG
A
MNVE
VKD
GK
I
-
---
V
S
STG
A
-
-
-
-
LAKTIPNS
L
QSTAADQVHTTA
RI
Q
HP
MVRKSY
L
D
N
P
LQPAKG
RGE
DTYVQV
SW
EQ
AL
KL
I
HEQ
H
D
RI
R
K
A
N
G
PS
A
I
F
--
-
-
AG
SY
G
WR
S
S
G
V
LHK
A
QT
L
LQ
R
Y
MN
LA
GG
Y
S
GH
S
G
D
YST
GAAQ
V
I
M
L
H
VV
GS
VEVYEQQTSW
P
L
IL
ENS
Q
A
VV
LW
G
M
NP
LN
T
LKIAWSSTDEQ
GL
E
Y
F-
-
H
QLK
KS
GK
P
V
I
A
IDP
IR
S
E
T
IEFF
G
DNAT
W
IAPNM
GTD
V
AL
ML
GIA
HT
L
M
T
QG
K
H
D
KV
FL
E
KY
TT
GY
PQ
-----
-
--
-
-
-
-
FEE
Y
LT
G
KS
-
D
N
T
P
K
SA
A
WAAEITG
V
P
EA
QI
V
KLA
-
E
LM
AA
NRTMLMA
GWG
I
QRQ
Q
Y
GEQ
K
H
WMLVT
L
AA
ML
G
QI
G
T
P
GG
GF
G
FSYHYSNGGNP
T
R
V
G
GV----
-
-
LP
E
M
S
AAIAG
Q
A
S
-
-
-
--
E
A
A
D
D
G
G-
MTAI
PVARIV
D
ALENPGGKYQHN
GKE
QTYPN
IK
M
IW
-
W
AG
GGN
F
TH
H
Q
D
T
N
R
LIK
A
W
Q
-
-
-
K
P
EMIVV
S
E
C
YW
TA
A
AK
H
ADI
V
LP
ITT
SF
E
RN
DL
T
MTGD
YS
N
Q
-
H
I
V
PM
KQ
A
VA
P
Q
FE
ARNDFD
V
FADL
A
EL
L
K
P
GGKE
I
Y
TEG
K
D
E
MA
WLKF
F
Y
DAAQKG
AR
AQ
R
V
T
MP
M
F
N
A
F
W
QQ
NK
L
IEMR
R
S
E
K
NE
Q
YV
R
Y
A
D
FR
A
DP
V
K
N
A
L
G
TPSGKIEIYS
KT
L
E
K
FGYKDCPAH
P
TW
--
-
---
-
L
A
P
--
-
-
---
-
D
E
W
K
G
T
A
D
E
K
-
Q
LQL
L
TA
H
PA
H
R
L
HS
Q
LNYA
E
L
R
K
K
YAV
A
D
R
EPIT
I
HTE
DA
A
R
F
GIANGD
L
VRV
W
N
K
RG
Q
IL
TG
A
V
VT
DG
I
KK
GV
V
C
V
HE
GAW
P
D
L
E
-
-
-
N
G
L
CKN
GS
A
N
V
LTA
D
I
PS
SQ
LA
NACA
G
N
S
A
LV
Y
IEKYTGNAPKLTAFD
K
PAVQA
fig|585057.4.peg.1235
Escherichia coli IAI39
MT
LT
RR
E
F
IK
H
S
G
I
AAG
AL
-
---
-
-
---
-
--
V
V
T
S
AAP
LP
AW
A
E
EK
-
--
G
G
K
I
LTA
G
RWG
A
MNVE
VKD
GK
I
-
---
V
S
STG
A
-
-
-
-
LAKTIPNS
L
QSTAADQVHTTA
RI
Q
HP
MVRKSY
L
D
N
P
LQPAKG
RGE
DTYVQV
SW
EQ
AL
KL
I
HEQ
H
D
RI
R
K
A
N
G
PS
A
I
F
--
-
-
AG
SY
G
WR
S
S
G
V
LHK
A
QT
L
LQ
R
Y
MN
LA
GG
Y
S
GH
S
G
D
YST
GAAQ
V
I
MP
H
VV
GS
VEVYEQQTSW
P
L
IL
ENS
QV
VV
LW
G
M
NP
LN
T
LKIAWSSTDEQ
GL
E
Y
F-
-
H
QLK
KS
GK
P
V
I
A
IDP
IR
S
E
T
IEFF
G
DNAT
W
IAPNM
GTD
V
AL
ML
GIA
HT
L
M
T
QG
K
H
D
K
A
FL
E
KY
TT
GY
PQ
-----
-
--
-
-
-
-
FEE
Y
LT
G
K
N
-
D
N
T
P
K
SA
A
WAAEITG
V
P
EA
QI
V
KLA
-
E
LM
AA
NRTMLMA
GWG
I
QRQ
Q
Y
GEQ
K
H
WMLVT
L
AA
ML
G
QI
G
T
P
GG
GF
G
FSYHYSNGGNP
T
R
V
G
GV----
-
-
LP
E
M
S
AAIAG
Q
A
S
-
-
-
--
E
E
A
D
D
G
G-
MTAI
PVARIV
D
ALENPGGKYQHN
GKE
QTYPN
IK
M
IW
-
W
AG
GGN
F
TH
H
Q
D
T
N
R
LIK
A
W
Q
-
-
-
K
P
EMIVV
S
E
C
YW
TA
A
AK
H
ADI
V
LP
ITT
SF
E
RN
DL
T
MTGD
YS
N
Q
-
H
I
V
PM
KQ
A
VA
P
Q
FE
ARNDFD
V
FADL
A
EL
L
K
P
GGKE
I
Y
TEG
K
D
E
MA
WLKF
F
Y
DAAQKG
AR
AQ
R
V
T
MP
M
F
N
A
F
W
QQ
NK
L
IEMR
R
S
E
K
NE
Q
YV
R
Y
G
D
FR
A
DP
V
K
N
A
L
G
TPSGKIEIYS
KT
L
E
K
FGYKDCPAH
P
TW
--
-
---
-
L
A
P
--
-
-
---
-
D
E
W
K
G
S
A
D
E
K
-
Q
LQL
L
TA
H
PA
H
R
L
HS
Q
LNYA
E
L
R
K
K
YAV
A
D
R
EPIT
I
HTE
DA
A
R
F
GIANGD
L
VRV
W
N
K
RG
Q
IL
TG
A
V
VT
DG
I
KK
GV
V
C
V
HE
GAW
P
D
L
E
-
-
-
N
G
L
CKN
GS
A
N
V
LTA
D
I
PS
SQ
LA
NACA
G
N
S
A
LV
Y
IEKYTGNAPKLTAFDQPAVQA
fig|585057.6.peg.1234
Escherichia coli IAI39
MT
LT
RR
E
F
IK
H
S
G
I
AAG
AL
-
---
-
-
---
-
--
V
V
T
S
AAP
LP
AW
A
E
EK
-
--
G
G
K
I
LTA
G
RWG
A
MNVE
VKD
GK
I
-
---
V
S
STG
A
-
-
-
-
LAKTIPNS
L
QSTAADQVHTTA
RI
Q
HP
MVRKSY
L
D
N
P
LQPAKG
RGE
DTYVQV
SW
EQ
AL
KL
I
HEQ
H
D
RI
R
K
A
N
G
PS
A
I
F
--
-
-
AG
SY
G
WR
S
S
G
V
LHK
A
QT
L
LQ
R
Y
MN
LA
GG
Y
S
GH
S
G
D
YST
GAAQ
V
I
MP
H
VV
GS
VEVYEQQTSW
P
L
IL
ENS
QV
VV
LW
G
M
NP
LN
T
LKIAWSSTDEQ
GL
E
Y
F-
-
H
QLK
KS
GK
P
V
I
A
IDP
IR
S
E
T
IEFF
G
DNAT
W
IAPNM
GTD
V
AL
ML
GIA
HT
L
M
T
QG
K
H
D
K
A
FL
E
KY
TT
GY
PQ
-----
-
--
-
-
-
-
FEE
Y
LT
G
K
N
-
D
N
T
P
K
SA
A
WAAEITG
V
P
EA
QI
V
KLA
-
E
LM
AA
NRTMLMA
GWG
I
QRQ
Q
Y
GEQ
K
H
WMLVT
L
AA
ML
G
QI
G
T
P
GG
GF
G
FSYHYSNGGNP
T
R
V
G
GV----
-
-
LP
E
M
S
AAIAG
Q
A
S
-
-
-
--
E
E
A
D
D
G
G-
MTAI
PVARIV
D
ALENPGGKYQHN
GKE
QTYPN
IK
M
IW
-
W
AG
GGN
F
TH
H
Q
D
T
N
R
LIK
A
W
Q
-
-
-
K
P
EMIVV
S
E
C
YW
TA
A
AK
H
ADI
V
LP
ITT
SF
E
RN
DL
T
MTGD
YS
N
Q
-
H
I
V
PM
KQ
A
VA
P
Q
FE
ARNDFD
V
FADL
A
EL
L
K
P
GGKE
I
Y
TEG
K
D
E
MA
WLKF
F
Y
DAAQKG
AR
AQ
R
V
T
MP
M
F
N
A
F
W
QQ
NK
L
IEMR
R
S
E
K
NE
Q
YV
R
Y
G
D
FR
A
DP
V
K
N
A
L
G
TPSGKIEIYS
KT
L
E
K
FGYKDCPAH
P
TW
--
-
---
-
L
A
P
--
-
-
---
-
D
E
W
K
G
S
A
D
E
K
-
Q
LQL
L
TA
H
PA
H
R
L
HS
Q
LNYA
E
L
R
K
K
YAV
A
D
R
EPIT
I
HTE
DA
A
R
F
GIANGD
L
VRV
W
N
K
RG
Q
IL
TG
A
V
VT
DG
I
KK
GV
V
C
V
HE
GAW
P
D
L
E
-
-
-
N
G
L
CKN
GS
A
N
V
LTA
D
I
PS
SQ
LA
NACA
G
N
S
A
LV
Y
IEKYTGNAPKLTAFDQPAVQA
fig|340184.3.peg.3183
Escherichia coli B7A
MT
LT
RR
E
F
IK
H
S
G
I
AAG
AL
-
---
-
-
---
-
--
V
V
T
S
AAP
LP
AW
A
E
EK
-
--
G
G
K
I
LTA
G
RWG
A
MNVE
VKD
GK
I
-
---
V
S
STG
A
-
-
-
-
LAKTIPNS
L
QSTAADQVHTTA
RI
Q
HP
MVRKSY
L
D
N
P
LQPAKG
RGE
DTYVQV
SW
EQ
AL
KL
I
HEQ
H
D
RI
R
K
A
N
G
PS
A
I
F
--
-
-
AG
SY
G
WR
S
S
G
V
LHK
A
QT
L
LQ
R
Y
MN
LA
GG
Y
S
GH
S
G
D
YST
GAAQ
V
I
MP
H
VV
GS
VEVYEQQTSW
P
L
IL
ENS
Q
A
VV
LW
G
M
NP
LN
T
LKIAWSSTDEQ
GL
E
Y
F-
-
H
QLK
KS
GK
P
V
I
A
IDP
IR
S
E
T
IEFF
G
DNAT
W
IAPNM
GTD
V
AL
ML
GIA
HT
L
M
T
QG
K
H
D
KV
FL
E
KY
TT
GY
PQ
-----
-
--
-
-
-
-
FEE
Y
LT
G
KS
-
D
N
T
P
K
SA
A
WAAEITG
V
P
EA
QI
V
KLA
-
E
LM
AA
NRTMLMA
GWG
I
QRQ
Q
Y
GEQ
K
H
WMLVT
L
AA
ML
G
QI
G
T
P
GG
GF
G
FSYHYSNGGNP
T
R
V
G
GV----
-
-
LP
E
M
S
AAIAG
Q
A
S
-
-
-
--
E
A
A
D
D
G
G-
MTAI
PVARIV
D
ALENPGGKYQHN
GKE
QTYPN
IK
M
IW
-
W
AG
GGN
F
TH
H
Q
D
T
N
R
LIK
A
W
Q
-
-
-
K
P
EMIV
A
S
E
C
YW
TA
A
AK
H
ADI
V
LP
ITT
SF
E
RN
DL
T
MTGD
YS
N
Q
-
H
I
V
PM
KQ
A
VA
P
Q
FE
ARNDFD
V
FADL
A
EL
L
K
P
GGKE
I
Y
TEG
K
D
E
MA
WLKF
F
Y
Y
AAQKG
AR
AQ
R
V
T
MP
M
F
N
A
F
W
QQ
NK
L
IEMR
R
S
E
K
NE
Q
YV
R
Y
A
D
FR
A
DP
V
K
N
A
L
G
TPSGKIEIYS
KT
L
E
K
FGYKDCPAH
P
TW
--
-
---
-
L
A
P
--
-
-
---
-
D
E
W
K
G
T
A
D
E
K
-
Q
LQL
L
TA
H
PA
H
R
L
HS
Q
LNYA
E
L
R
K
K
YAV
A
D
R
EPIT
I
HTE
DA
A
R
F
GIANGD
L
VRV
W
N
K
RG
Q
IL
TG
A
V
VT
DG
I
KK
GV
V
C
V
HE
GAW
P
D
L
E
-
-
-
N
G
L
CKN
GS
A
N
V
LTA
D
I
PS
SQ
LA
NACA
G
N
S
A
LV
Y
IEKYTGNAPKLTAFD
K
PA
I
QA
fig|340184.6.peg.3322
Escherichia coli B7A
MT
LT
RR
E
F
IK
H
S
G
I
AAG
AL
-
---
-
-
---
-
--
V
V
T
S
AAP
LP
AW
A
E
EK
-
--
G
G
K
I
LTA
G
RWG
A
MNVE
VKD
GK
I
-
---
V
S
STG
A
-
-
-
-
LAKTIPNS
L
QSTAADQVHTTA
RI
Q
HP
MVRKSY
L
D
N
P
LQPAKG
RGE
DTYVQV
SW
EQ
AL
KL
I
HEQ
H
D
RI
R
K
A
N
G
PS
A
I
F
--
-
-
AG
SY
G
WR
S
S
G
V
LHK
A
QT
L
LQ
R
Y
MN
LA
GG
Y
S
GH
S
G
D
YST
GAAQ
V
I
MP
H
VV
GS
VEVYEQQTSW
P
L
IL
ENS
Q
A
VV
LW
G
M
NP
LN
T
LKIAWSSTDEQ
GL
E
Y
F-
-
H
QLK
KS
GK
P
V
I
A
IDP
IR
S
E
T
IEFF
G
DNAT
W
IAPNM
GTD
V
AL
ML
GIA
HT
L
M
T
QG
K
H
D
KV
FL
E
KY
TT
GY
PQ
-----
-
--
-
-
-
-
FEE
Y
LT
G
KS
-
D
N
T
P
K
SA
A
WAAEITG
V
P
EA
QI
V
KLA
-
E
LM
AA
NRTMLMA
GWG
I
QRQ
Q
Y
GEQ
K
H
WMLVT
L
AA
ML
G
QI
G
T
P
GG
GF
G
FSYHYSNGGNP
T
R
V
G
GV----
-
-
LP
E
M
S
AAIAG
Q
A
S
-
-
-
--
E
A
A
D
D
G
G-
MTAI
PVARIV
D
ALENPGGKYQHN
GKE
QTYPN
IK
M
IW
-
W
AG
GGN
F
TH
H
Q
D
T
N
R
LIK
A
W
Q
-
-
-
K
P
EMIV
A
S
E
C
YW
TA
A
AK
H
ADI
V
LP
ITT
SF
E
RN
DL
T
MTGD
YS
N
Q
-
H
I
V
PM
KQ
A
VA
P
Q
FE
ARNDFD
V
FADL
A
EL
L
K
P
GGKE
I
Y
TEG
K
D
E
MA
WLKF
F
Y
Y
AAQKG
AR
AQ
R
V
T
MP
M
F
N
A
F
W
QQ
NK
L
IEMR
R
S
E
K
NE
Q
YV
R
Y
A
D
FR
A
DP
V
K
N
A
L
G
TPSGKIEIYS
KT
L
E
K
FGYKDCPAH
P
TW
--
-
---
-
L
A
P
--
-
-
---
-
D
E
W
K
G
T
A
D
E
K
-
Q
LQL
L
TA
H
PA
H
R
L
HS
Q
LNYA
E
L
R
K
K
YAV
A
D
R
EPIT
I
HTE
DA
A
R
F
GIANGD
L
VRV
W
N
K
RG
Q
IL
TG
A
V
VT
DG
I
KK
GV
V
C
V
HE
GAW
P
D
L
E
-
-
-
N
G
L
CKN
GS
A
N
V
LTA
D
I
PS
SQ
LA
NACA
G
N
S
A
LV
Y
IEKYTGNAPKLTAFD
K
PA
I
QA
fig|562.371.peg.4749
Escherichia coli 1044A
MT
LT
RR
E
F
IK
H
S
G
I
AAG
AL
-
---
-
-
---
-
--
V
V
T
S
AAP
LP
AW
A
E
EK
-
--
G
G
K
I
LTA
G
RWG
A
MNVE
VKD
GK
I
-
---
V
S
STG
A
-
-
-
-
LAKTIPNS
L
QSTAADQVHTTA
RI
Q
HP
MVRKSY
L
D
N
P
LQPAKG
RGE
DTYVQV
SW
EQ
AL
KL
I
HEQ
H
E
RI
R
K
A
N
G
PS
A
I
F
--
-
-
AG
SY
G
WR
S
S
G
V
LHK
A
QT
L
LQ
R
Y
MN
LA
GG
Y
S
GH
S
G
D
YST
GAAQ
V
I
MP
H
VV
GS
VEVYEQQTSW
P
L
IL
ENS
QV
VV
LW
G
M
NP
LN
T
LKIAWSSTDEQ
GL
E
Y
F-
-
H
QLK
KS
GK
P
V
I
A
IDP
IR
S
E
T
IEFF
G
Y
NAT
W
IAPNM
GTD
V
AL
ML
GIA
HT
L
M
T
QG
K
H
D
KV
FL
E
KY
TT
GY
PQ
-----
-
--
-
-
-
-
FEE
Y
LT
G
KS
-
D
N
T
P
K
SA
A
W
T
AEITG
V
P
EA
QI
V
KLA
-
E
LM
AA
NRTMLMA
GWG
I
QRQ
Q
Y
GEQ
K
H
WMLVT
L
AA
ML
G
QI
G
T
P
GG
GF
G
FSYHYSNGGNP
T
R
V
G
GV----
-
-
LP
E
M
S
AAIAG
Q
A
S
-
-
-
--
E
A
A
D
D
G
G-
MTAI
PVARIV
D
ALENPGGKYQHN
GKE
QTYPN
IK
M
IW
-
W
AG
GGN
F
TH
H
Q
D
T
N
R
LIK
A
W
Q
-
-
-
K
P
EMIVV
S
E
C
YW
TA
A
AK
H
ADI
V
LP
ITT
SF
E
RN
DL
T
MTGD
YS
N
Q
-
H
I
V
PM
KQ
A
VA
P
Q
FE
ARNDFD
V
FA
E
L
A
EL
L
K
P
GGKE
I
Y
TEG
K
D
E
MA
WLKF
F
Y
DAAQKG
AR
AQ
R
V
T
MP
M
F
N
A
F
W
QQ
NK
L
IEMR
R
S
E
K
NE
Q
YV
R
Y
G
D
FR
A
DP
V
K
N
A
L
G
TPSGKIEIYS
KT
L
E
K
FGYKDCPAH
P
TW
--
-
---
-
L
A
P
--
-
-
---
-
D
E
W
K
G
T
A
D
E
K
-
Q
LQL
L
TA
H
PA
H
R
L
HS
Q
LNYA
Q
L
R
K
K
YAV
A
D
R
EPIT
I
HTE
DA
A
R
F
GIANGD
L
VRV
W
N
K
RG
Q
IL
TG
A
V
VT
DG
I
KK
GV
V
C
V
HE
GAW
P
D
L
E
-
-
-
N
G
L
CKN
GS
A
N
V
LTA
D
I
PS
SQ
LA
NACA
G
N
S
A
LV
Y
IEKYTGNAPKLTAFDQPAVQA
fig|562.372.peg.4979
Escherichia coli 1212A
MT
LT
RR
E
F
IK
H
S
G
I
AAG
AL
-
---
-
-
---
-
--
V
V
T
S
AAP
LP
AW
A
E
EK
-
--
G
G
K
I
LTA
G
RWG
A
MNVE
VKD
GK
I
-
---
V
S
STG
A
-
-
-
-
LAKTIPNS
L
QSTAADQVHTTA
RI
Q
HP
MVRKSY
L
D
N
P
LQPAKG
RGE
DTYVQV
SW
EQ
AL
KL
I
HEQ
H
E
RI
R
K
A
N
G
PS
A
I
F
--
-
-
AG
SY
G
WR
S
S
G
V
LHK
A
QT
L
LQ
R
Y
MN
LA
GG
Y
S
GH
S
G
D
YST
GAAQ
V
I
MP
H
VV
GS
VEVYEQQTSW
P
L
IL
ENS
QV
VV
LW
G
M
NP
LN
T
LKIAWSSTDEQ
GL
E
Y
F-
-
H
QLK
KS
GK
P
V
I
A
IDP
IR
S
E
T
IEFF
G
Y
NAT
W
IAPNM
GTD
V
AL
ML
GIA
HT
L
M
T
QG
K
H
D
KV
FL
E
KY
TT
GY
PQ
-----
-
--
-
-
-
-
FEE
Y
LT
G
KS
-
D
N
T
P
K
SA
A
W
T
AEITG
V
P
EA
QI
V
KLA
-
E
LM
AA
NRTMLMA
GWG
I
QRQ
Q
Y
GEQ
K
H
WMLVT
L
AA
ML
G
QI
G
T
P
GG
GF
G
FSYHYSNGGNP
T
R
V
G
GV----
-
-
LP
E
M
S
AAIAG
Q
A
S
-
-
-
--
E
A
A
D
D
G
G-
MTAI
PVARIV
D
ALENPGGKYQHN
GKE
QTYPN
IK
M
IW
-
W
AG
GGN
F
TH
H
Q
D
T
N
R
LIK
A
W
Q
-
-
-
K
P
EMIVV
S
E
C
YW
TA
A
AK
H
ADI
V
LP
ITT
SF
E
RN
DL
T
MTGD
YS
N
Q
-
H
I
V
PM
KQ
A
VA
P
Q
FE
ARNDFD
V
FA
E
L
A
EL
L
K
P
GGKE
I
Y
TEG
K
D
E
MA
WLKF
F
Y
DAAQKG
AR
AQ
R
V
T
MP
M
F
N
A
F
W
QQ
NK
L
IEMR
R
S
E
K
NE
Q
YV
R
Y
G
D
FR
A
DP
V
K
N
A
L
G
TPSGKIEIYS
KT
L
E
K
FGYKDCPAH
P
TW
--
-
---
-
L
A
P
--
-
-
---
-
D
E
W
K
G
T
A
D
E
K
-
Q
LQL
L
TA
H
PA
H
R
L
HS
Q
LNYA
Q
L
R
K
K
YAV
A
D
R
EPIT
I
HTE
DA
A
R
F
GIANGD
L
VRV
W
N
K
RG
Q
IL
TG
A
V
VT
DG
I
KK
GV
V
C
V
HE
GAW
P
D
L
E
-
-
-
N
G
L
CKN
GS
A
N
V
LTA
D
I
PS
SQ
LA
NACA
G
N
S
A
LV
Y
IEKYTGNAPKLTAFDQPAVQA
fig|562.374.peg.4131
Escherichia coli 536A
MT
LT
RR
E
F
IK
H
S
G
I
AAG
AL
-
---
-
-
---
-
--
V
V
T
S
AAP
LP
AW
A
E
EK
-
--
G
G
K
I
LTA
G
RWG
A
MNVE
VKD
GK
I
-
---
V
S
STG
A
-
-
-
-
LAKTIPNS
L
QSTAADQVHTTA
RI
Q
HP
MVRKSY
L
D
N
P
LQPAKG
RGE
DTYVQV
SW
EQ
AL
KL
I
HEQ
H
E
RI
R
K
A
N
G
PS
A
I
F
--
-
-
AG
SY
G
WR
S
S
G
V
LHK
A
QT
L
LQ
R
Y
MN
LA
GG
Y
S
GH
S
G
D
YST
GAAQ
V
I
MP
H
VV
GS
VEVYEQQTSW
P
L
IL
ENS
QV
VV
LW
G
M
NP
LN
T
LKIAWSSTDEQ
GL
E
Y
F-
-
H
QLK
KS
GK
P
V
I
A
IDP
IR
S
E
T
IEFF
G
Y
NAT
W
IAPNM
GTD
V
AL
ML
GIA
HT
L
M
T
QG
K
H
D
KV
FL
E
KY
TT
GY
PQ
-----
-
--
-
-
-
-
FEE
Y
LT
G
KS
-
D
N
T
P
K
SA
A
W
T
AEITG
V
P
EA
QI
V
KLA
-
E
LM
AA
NRTMLMA
GWG
I
QRQ
Q
Y
GEQ
K
H
WMLVT
L
AA
ML
G
QI
G
T
P
GG
GF
G
FSYHYSNGGNP
T
R
V
G
GV----
-
-
LP
E
M
S
AAIAG
Q
A
S
-
-
-
--
E
A
A
D
D
G
G-
MTAI
PVARIV
D
ALENPGGKYQHN
GKE
QTYPN
IK
M
IW
-
W
AG
GGN
F
TH
H
Q
D
T
N
R
LIK
A
W
Q
-
-
-
K
P
EMIVV
S
E
C
YW
TA
A
AK
H
ADI
V
LP
ITT
SF
E
RN
DL
T
MTGD
YS
N
Q
-
H
I
V
PM
KQ
A
VA
P
Q
FE
ARNDFD
V
FA
E
L
A
EL
L
K
P
GGKE
I
Y
TEG
K
D
E
MA
WLKF
F
Y
DAAQKG
AR
AQ
R
V
T
MP
M
F
N
A
F
W
QQ
NK
L
IEMR
R
S
E
K
NE
Q
YV
R
Y
G
D
FR
A
DP
V
K
N
A
L
G
TPSGKIEIYS
KT
L
E
K
FGYKDCPAH
P
TW
--
-
---
-
L
A
P
--
-
-
---
-
D
E
W
K
G
T
A
D
E
K
-
Q
LQL
L
TA
H
PA
H
R
L
HS
Q
LNYA
Q
L
R
K
K
YAV
A
D
R
EPIT
I
HTE
DA
A
R
F
GIANGD
L
VRV
W
N
K
RG
Q
IL
TG
A
V
VT
DG
I
KK
GV
V
C
V
HE
GAW
P
D
L
E
-
-
-
N
G
L
CKN
GS
A
N
V
LTA
D
I
PS
SQ
LA
NACA
G
N
S
A
LV
Y
IEKYTGNAPKLTAFDQPAVQA
fig|83334.1.peg.2609
Escherichia coli O157:H7
MT
LT
RR
E
F
IK
H
S
G
I
AAG
AL
-
---
-
-
---
-
--
V
V
T
S
AAP
LP
AW
A
E
EK
-
--
G
G
K
I
LTA
G
RWG
A
MNVE
VKD
GK
I
-
---
V
S
STG
A
-
-
-
-
LAKTIPNS
L
QSTAADQVHTTA
RI
Q
HP
MVRKSY
L
D
N
P
LQPAKG
RGE
DTYVQV
SW
EQ
AL
KL
I
HEQ
H
E
RI
R
K
A
N
G
PS
A
I
F
--
-
-
AG
SY
G
WR
S
S
G
V
LHK
A
QT
L
LQ
R
Y
MN
LA
GG
Y
S
GH
S
G
D
YST
GAAQ
V
I
MP
H
VV
GS
VEVYEQQTSW
P
L
IL
ENS
QV
VV
LW
G
M
NP
LN
T
LKIAWSSTDEQ
GL
E
Y
F-
-
H
QLK
KS
GK
P
V
I
A
IDP
IR
S
E
T
IEFF
G
Y
NAT
W
IAPNM
GTD
V
AL
ML
GIA
HT
L
M
T
QG
K
H
D
KV
FL
E
KY
TT
GY
PQ
-----
-
--
-
-
-
-
FEE
Y
LT
G
KS
-
D
N
T
P
K
SA
A
W
T
AEITG
V
P
EA
QI
V
KLA
-
E
LM
AA
NRTMLMA
GWG
I
QRQ
Q
Y
GEQ
K
H
WMLVT
L
AA
ML
G
QI
G
T
P
GG
GF
G
FSYHYSNGGNP
T
R
V
G
GV----
-
-
LP
E
M
S
AAIAG
Q
A
S
-
-
-
--
E
A
A
D
D
G
G-
MTAI
PVARIV
D
ALENPGGKYQHN
GKE
QTYPN
IK
M
IW
-
W
AG
GGN
F
TH
H
Q
D
T
N
R
LIK
A
W
Q
-
-
-
K
P
EMIVV
S
E
C
YW
TA
A
AK
H
ADI
V
LP
ITT
SF
E
RN
DL
T
MTGD
YS
N
Q
-
H
I
V
PM
KQ
A
VA
P
Q
FE
ARNDFD
V
FA
E
L
A
EL
L
K
P
GGKE
I
Y
TEG
K
D
E
MA
WLKF
F
Y
DAAQKG
AR
AQ
R
V
T
MP
M
F
N
A
F
W
QQ
NK
L
IEMR
R
S
E
K
NE
Q
YV
R
Y
G
D
FR
A
DP
V
K
N
A
L
G
TPSGKIEIYS
KT
L
E
K
FGYKDCPAH
P
TW
--
-
---
-
L
A
P
--
-
-
---
-
D
E
W
K
G
T
A
D
E
K
-
Q
LQL
L
TA
H
PA
H
R
L
HS
Q
LNYA
Q
L
R
K
K
YAV
A
D
R
EPIT
I
HTE
DA
A
R
F
GIANGD
L
VRV
W
N
K
RG
Q
IL
TG
A
V
VT
DG
I
KK
GV
V
C
V
HE
GAW
P
D
L
E
-
-
-
N
G
L
CKN
GS
A
N
V
LTA
D
I
PS
SQ
LA
NACA
G
N
S
A
LV
Y
IEKYTGNAPKLTAFDQPAVQA
fig|155864.1.peg.2617
Escherichia coli O157:H7 EDL933 (7-815/815)
MT
LT
RR
E
F
IK
H
S
G
I
AAG
AL
-
---
-
-
---
-
--
V
V
T
S
AAP
LP
AW
A
E
EK
-
--
G
G
K
I
LTA
G
RWG
A
MNVE
VKD
GK
I
-
---
V
S
STG
A
-
-
-
-
LAKTIPNS
L
QSTAADQVHTTA
RI
Q
HP
MVRKSY
L
D
N
P
LQPAKG
RGE
DTYVQV
SW
EQ
AL
KL
I
HEQ
H
E
RI
R
K
A
N
G
PS
A
I
F
--
-
-
AG
SY
G
WR
S
S
G
V
LHK
A
QT
L
LQ
R
Y
MN
LA
GG
Y
S
GH
S
G
D
YST
GAAQ
V
I
MP
H
VV
GS
VEVYEQQTSW
P
L
IL
ENS
QV
VV
LW
G
M
NP
LN
T
LKIAWSSTDEQ
GL
E
Y
F-
-
H
QLK
KS
GK
P
V
I
A
IDP
IR
S
E
T
IEFF
G
Y
NAT
W
IAPNM
GTD
V
AL
ML
GIA
HT
L
M
T
QG
K
H
D
KV
FL
E
KY
TT
GY
PQ
-----
-
--
-
-
-
-
FEE
Y
LT
G
KS
-
D
N
T
P
K
SA
A
W
T
AEITG
V
P
EA
QI
V
KLA
-
E
LM
AA
NRTMLMA
GWG
I
QRQ
Q
Y
GEQ
K
H
WMLVT
L
AA
ML
G
QI
G
T
P
GG
GF
G
FSYHYSNGGNP
T
R
V
G
GV----
-
-
LP
E
M
S
AAIAG
Q
A
S
-
-
-
--
E
A
A
D
D
G
G-
MTAI
PVARIV
D
ALENPGGKYQHN
GKE
QTYPN
IK
M
IW
-
W
AG
GGN
F
TH
H
Q
D
T
N
R
LIK
A
W
Q
-
-
-
K
P
EMIVV
S
E
C
YW
TA
A
AK
H
ADI
V
LP
ITT
SF
E
RN
DL
T
MTGD
YS
N
Q
-
H
I
V
PM
KQ
A
VA
P
Q
FE
ARNDFD
V
FA
E
L
A
EL
L
K
P
GGKE
I
Y
TEG
K
D
E
MA
WLKF
F
Y
DAAQKG
AR
AQ
R
V
T
MP
M
F
N
A
F
W
QQ
NK
L
IEMR
R
S
E
K
NE
Q
YV
R
Y
G
D
FR
A
DP
V
K
N
A
L
G
TPSGKIEIYS
KT
L
E
K
FGYKDCPAH
P
TW
--
-
---
-
L
A
P
--
-
-
---
-
D
E
W
K
G
T
A
D
E
K
-
Q
LQL
L
TA
H
PA
H
R
L
HS
Q
LNYA
Q
L
R
K
K
YAV
A
D
R
EPIT
I
HTE
DA
A
R
F
GIANGD
L
VRV
W
N
K
RG
Q
IL
TG
A
V
VT
DG
I
KK
GV
V
C
V
HE
GAW
P
D
L
E
-
-
-
N
G
L
CKN
GS
A
N
V
LTA
D
I
PS
SQ
LA
NACA
G
N
S
A
LV
Y
IEKYTGNAPKLTAFDQPAVQA
fig|155864.8.peg.2480
Escherichia coli O157:H7 EDL933
MT
LT
RR
E
F
IK
H
S
G
I
AAG
AL
-
---
-
-
---
-
--
V
V
T
S
AAP
LP
AW
A
E
EK
-
--
G
G
K
I
LTA
G
RWG
A
MNVE
VKD
GK
I
-
---
V
S
STG
A
-
-
-
-
LAKTIPNS
L
QSTAADQVHTTA
RI
Q
HP
MVRKSY
L
D
N
P
LQPAKG
RGE
DTYVQV
SW
EQ
AL
KL
I
HEQ
H
E
RI
R
K
A
N
G
PS
A
I
F
--
-
-
AG
SY
G
WR
S
S
G
V
LHK
A
QT
L
LQ
R
Y
MN
LA
GG
Y
S
GH
S
G
D
YST
GAAQ
V
I
MP
H
VV
GS
VEVYEQQTSW
P
L
IL
ENS
QV
VV
LW
G
M
NP
LN
T
LKIAWSSTDEQ
GL
E
Y
F-
-
H
QLK
KS
GK
P
V
I
A
IDP
IR
S
E
T
IEFF
G
Y
NAT
W
IAPNM
GTD
V
AL
ML
GIA
HT
L
M
T
QG
K
H
D
KV
FL
E
KY
TT
GY
PQ
-----
-
--
-
-
-
-
FEE
Y
LT
G
KS
-
D
N
T
P
K
SA
A
W
T
AEITG
V
P
EA
QI
V
KLA
-
E
LM
AA
NRTMLMA
GWG
I
QRQ
Q
Y
GEQ
K
H
WMLVT
L
AA
ML
G
QI
G
T
P
GG
GF
G
FSYHYSNGGNP
T
R
V
G
GV----
-
-
LP
E
M
S
AAIAG
Q
A
S
-
-
-
--
E
A
A
D
D
G
G-
MTAI
PVARIV
D
ALENPGGKYQHN
GKE
QTYPN
IK
M
IW
-
W
AG
GGN
F
TH
H
Q
D
T
N
R
LIK
A
W
Q
-
-
-
K
P
EMIVV
S
E
C
YW
TA
A
AK
H
ADI
V
LP
ITT
SF
E
RN
DL
T
MTGD
YS
N
Q
-
H
I
V
PM
KQ
A
VA
P
Q
FE
ARNDFD
V
FA
E
L
A
EL
L
K
P
GGKE
I
Y
TEG
K
D
E
MA
WLKF
F
Y
DAAQKG
AR
AQ
R
V
T
MP
M
F
N
A
F
W
QQ
NK
L
IEMR
R
S
E
K
NE
Q
YV
R
Y
G
D
FR
A
DP
V
K
N
A
L
G
TPSGKIEIYS
KT
L
E
K
FGYKDCPAH
P
TW
--
-
---
-
L
A
P
--
-
-
---
-
D
E
W
K
G
T
A
D
E
K
-
Q
LQL
L
TA
H
PA
H
R
L
HS
Q
LNYA
Q
L
R
K
K
YAV
A
D
R
EPIT
I
HTE
DA
A
R
F
GIANGD
L
VRV
W
N
K
RG
Q
IL
TG
A
V
VT
DG
I
KK
GV
V
C
V
HE
GAW
P
D
L
E
-
-
-
N
G
L
CKN
GS
A
N
V
LTA
D
I
PS
SQ
LA
NACA
G
N
S
A
LV
Y
IEKYTGNAPKLTAFDQPAVQA
fig|444454.5.peg.1343
Escherichia coli O157:H7 str. EC4024
MT
LT
RR
E
F
IK
H
S
G
I
AAG
AL
-
---
-
-
---
-
--
V
V
T
S
AAP
LP
AW
A
E
EK
-
--
G
G
K
I
LTA
G
RWG
A
MNVE
VKD
GK
I
-
---
V
S
STG
A
-
-
-
-
LAKTIPNS
L
QSTAADQVHTTA
RI
Q
HP
MVRKSY
L
D
N
P
LQPAKG
RGE
DTYVQV
SW
EQ
AL
KL
I
HEQ
H
E
RI
R
K
A
N
G
PS
A
I
F
--
-
-
AG
SY
G
WR
S
S
G
V
LHK
A
QT
L
LQ
R
Y
MN
LA
GG
Y
S
GH
S
G
D
YST
GAAQ
V
I
MP
H
VV
GS
VEVYEQQTSW
P
L
IL
ENS
QV
VV
LW
G
M
NP
LN
T
LKIAWSSTDEQ
GL
E
Y
F-
-
H
QLK
KS
GK
P
V
I
A
IDP
IR
S
E
T
IEFF
G
Y
NAT
W
IAPNM
GTD
V
AL
ML
GIA
HT
L
M
T
QG
K
H
D
KV
FL
E
KY
TT
GY
PQ
-----
-
--
-
-
-
-
FEE
Y
LT
G
KS
-
D
N
T
P
K
SA
A
W
T
AEITG
V
P
EA
QI
V
KLA
-
E
LM
AA
NRTMLMA
GWG
I
QRQ
Q
Y
GEQ
K
H
WMLVT
L
AA
ML
G
QI
G
T
P
GG
GF
G
FSYHYSNGGNP
T
R
V
G
GV----
-
-
LP
E
M
S
AAIAG
Q
A
S
-
-
-
--
E
A
A
D
D
G
G-
MTAI
PVARIV
D
ALENPGGKYQHN
GKE
QTYPN
IK
M
IW
-
W
AG
GGN
F
TH
H
Q
D
T
N
R
LIK
A
W
Q
-
-
-
K
P
EMIVV
S
E
C
YW
TA
A
AK
H
ADI
V
LP
ITT
SF
E
RN
DL
T
MTGD
YS
N
Q
-
H
I
V
PM
KQ
A
VA
P
Q
FE
ARNDFD
V
FA
E
L
A
EL
L
K
P
GGKE
I
Y
TEG
K
D
E
MA
WLKF
F
Y
DAAQKG
AR
AQ
R
V
T
MP
M
F
N
A
F
W
QQ
NK
L
IEMR
R
S
E
K
NE
Q
YV
R
Y
G
D
FR
A
DP
V
K
N
A
L
G
TPSGKIEIYS
KT
L
E
K
FGYKDCPAH
P
TW
--
-
---
-
L
A
P
--
-
-
---
-
D
E
W
K
G
T
A
D
E
K
-
Q
LQL
L
TA
H
PA
H
R
L
HS
Q
LNYA
Q
L
R
K
K
YAV
A
D
R
EPIT
I
HTE
DA
A
R
F
GIANGD
L
VRV
W
N
K
RG
Q
IL
TG
A
V
VT
DG
I
KK
GV
V
C
V
HE
GAW
P
D
L
E
-
-
-
N
G
L
CKN
GS
A
N
V
LTA
D
I
PS
SQ
LA
NACA
G
N
S
A
LV
Y
IEKYTGNAPKLTAFDQPAVQA
fig|444449.5.peg.843
Escherichia coli O157:H7 str. EC4042
MT
LT
RR
E
F
IK
H
S
G
I
AAG
AL
-
---
-
-
---
-
--
V
V
T
S
AAP
LP
AW
A
E
EK
-
--
G
G
K
I
LTA
G
RWG
A
MNVE
VKD
GK
I
-
---
V
S
STG
A
-
-
-
-
LAKTIPNS
L
QSTAADQVHTTA
RI
Q
HP
MVRKSY
L
D
N
P
LQPAKG
RGE
DTYVQV
SW
EQ
AL
KL
I
HEQ
H
E
RI
R
K
A
N
G
PS
A
I
F
--
-
-
AG
SY
G
WR
S
S
G
V
LHK
A
QT
L
LQ
R
Y
MN
LA
GG
Y
S
GH
S
G
D
YST
GAAQ
V
I
MP
H
VV
GS
VEVYEQQTSW
P
L
IL
ENS
QV
VV
LW
G
M
NP
LN
T
LKIAWSSTDEQ
GL
E
Y
F-
-
H
QLK
KS
GK
P
V
I
A
IDP
IR
S
E
T
IEFF
G
Y
NAT
W
IAPNM
GTD
V
AL
ML
GIA
HT
L
M
T
QG
K
H
D
KV
FL
E
KY
TT
GY
PQ
-----
-
--
-
-
-
-
FEE
Y
LT
G
KS
-
D
N
T
P
K
SA
A
W
T
AEITG
V
P
EA
QI
V
KLA
-
E
LM
AA
NRTMLMA
GWG
I
QRQ
Q
Y
GEQ
K
H
WMLVT
L
AA
ML
G
QI
G
T
P
GG
GF
G
FSYHYSNGGNP
T
R
V
G
GV----
-
-
LP
E
M
S
AAIAG
Q
A
S
-
-
-
--
E
A
A
D
D
G
G-
MTAI
PVARIV
D
ALENPGGKYQHN
GKE
QTYPN
IK
M
IW
-
W
AG
GGN
F
TH
H
Q
D
T
N
R
LIK
A
W
Q
-
-
-
K
P
EMIVV
S
E
C
YW
TA
A
AK
H
ADI
V
LP
ITT
SF
E
RN
DL
T
MTGD
YS
N
Q
-
H
I
V
PM
KQ
A
VA
P
Q
FE
ARNDFD
V
FA
E
L
A
EL
L
K
P
GGKE
I
Y
TEG
K
D
E
MA
WLKF
F
Y
DAAQKG
AR
AQ
R
V
T
MP
M
F
N
A
F
W
QQ
NK
L
IEMR
R
S
E
K
NE
Q
YV
R
Y
G
D
FR
A
DP
V
K
N
A
L
G
TPSGKIEIYS
KT
L
E
K
FGYKDCPAH
P
TW
--
-
---
-
L
A
P
--
-
-
---
-
D
E
W
K
G
T
A
D
E
K
-
Q
LQL
L
TA
H
PA
H
R
L
HS
Q
LNYA
Q
L
R
K
K
YAV
A
D
R
EPIT
I
HTE
DA
A
R
F
GIANGD
L
VRV
W
N
K
RG
Q
IL
TG
A
V
VT
DG
I
KK
GV
V
C
V
HE
GAW
P
D
L
E
-
-
-
N
G
L
CKN
GS
A
N
V
LTA
D
I
PS
SQ
LA
NACA
G
N
S
A
LV
Y
IEKYTGNAPKLTAFDQPAVQA
fig|444448.5.peg.5131
Escherichia coli O157:H7 str. EC4045
MT
LT
RR
E
F
IK
H
S
G
I
AAG
AL
-
---
-
-
---
-
--
V
V
T
S
AAP
LP
AW
A
E
EK
-
--
G
G
K
I
LTA
G
RWG
A
MNVE
VKD
GK
I
-
---
V
S
STG
A
-
-
-
-
LAKTIPNS
L
QSTAADQVHTTA
RI
Q
HP
MVRKSY
L
D
N
P
LQPAKG
RGE
DTYVQV
SW
EQ
AL
KL
I
HEQ
H
E
RI
R
K
A
N
G
PS
A
I
F
--
-
-
AG
SY
G
WR
S
S
G
V
LHK
A
QT
L
LQ
R
Y
MN
LA
GG
Y
S
GH
S
G
D
YST
GAAQ
V
I
MP
H
VV
GS
VEVYEQQTSW
P
L
IL
ENS
QV
VV
LW
G
M
NP
LN
T
LKIAWSSTDEQ
GL
E
Y
F-
-
H
QLK
KS
GK
P
V
I
A
IDP
IR
S
E
T
IEFF
G
Y
NAT
W
IAPNM
GTD
V
AL
ML
GIA
HT
L
M
T
QG
K
H
D
KV
FL
E
KY
TT
GY
PQ
-----
-
--
-
-
-
-
FEE
Y
LT
G
KS
-
D
N
T
P
K
SA
A
W
T
AEITG
V
P
EA
QI
V
KLA
-
E
LM
AA
NRTMLMA
GWG
I
QRQ
Q
Y
GEQ
K
H
WMLVT
L
AA
ML
G
QI
G
T
P
GG
GF
G
FSYHYSNGGNP
T
R
V
G
GV----
-
-
LP
E
M
S
AAIAG
Q
A
S
-
-
-
--
E
A
A
D
D
G
G-
MTAI
PVARIV
D
ALENPGGKYQHN
GKE
QTYPN
IK
M
IW
-
W
AG
GGN
F
TH
H
Q
D
T
N
R
LIK
A
W
Q
-
-
-
K
P
EMIVV
S
E
C
YW
TA
A
AK
H
ADI
V
LP
ITT
SF
E
RN
DL
T
MTGD
YS
N
Q
-
H
I
V
PM
KQ
A
VA
P
Q
FE
ARNDFD
V
FA
E
L
A
EL
L
K
P
GGKE
I
Y
TEG
K
D
E
MA
WLKF
F
Y
DAAQKG
AR
AQ
R
V
T
MP
M
F
N
A
F
W
QQ
NK
L
IEMR
R
S
E
K
NE
Q
YV
R
Y
G
D
FR
A
DP
V
K
N
A
L
G
TPSGKIEIYS
KT
L
E
K
FGYKDCPAH
P
TW
--
-
---
-
L
A
P
--
-
-
---
-
D
E
W
K
G
T
A
D
E
K
-
Q
LQL
L
TA
H
PA
H
R
L
HS
Q
LNYA
Q
L
R
K
K
YAV
A
D
R
EPIT
I
HTE
DA
A
R
F
GIANGD
L
VRV
W
N
K
RG
Q
IL
TG
A
V
VT
DG
I
KK
GV
V
C
V
HE
GAW
P
D
L
E
-
-
-
N
G
L
CKN
GS
A
N
V
LTA
D
I
PS
SQ
LA
NACA
G
N
S
A
LV
Y
IEKYTGNAPKLTAFDQPAVQA
fig|444453.5.peg.4463
Escherichia coli O157:H7 str. EC4076
MT
LT
RR
E
F
IK
H
S
G
I
AAG
AL
-
---
-
-
---
-
--
V
V
T
S
AAP
LP
AW
A
E
EK
-
--
G
G
K
I
LTA
G
RWG
A
MNVE
VKD
GK
I
-
---
V
S
STG
A
-
-
-
-
LAKTIPNS
L
QSTAADQVHTTA
RI
Q
HP
MVRKSY
L
D
N
P
LQPAKG
RGE
DTYVQV
SW
EQ
AL
KL
I
HEQ
H
E
RI
R
K
A
N
G
PS
A
I
F
--
-
-
AG
SY
G
WR
S
S
G
V
LHK
A
QT
L
LQ
R
Y
MN
LA
GG
Y
S
GH
S
G
D
YST
GAAQ
V
I
MP
H
VV
GS
VEVYEQQTSW
P
L
IL
ENS
QV
VV
LW
G
M
NP
LN
T
LKIAWSSTDEQ
GL
E
Y
F-
-
H
QLK
KS
GK
P
V
I
A
IDP
IR
S
E
T
IEFF
G
Y
NAT
W
IAPNM
GTD
V
AL
ML
GIA
HT
L
M
T
QG
K
H
D
KV
FL
E
KY
TT
GY
PQ
-----
-
--
-
-
-
-
FEE
Y
LT
G
KS
-
D
N
T
P
K
SA
A
W
T
AEITG
V
P
EA
QI
V
KLA
-
E
LM
AA
NRTMLMA
GWG
I
QRQ
Q
Y
GEQ
K
H
WMLVT
L
AA
ML
G
QI
G
T
P
GG
GF
G
FSYHYSNGGNP
T
R
V
G
GV----
-
-
LP
E
M
S
AAIAG
Q
A
S
-
-
-
--
E
A
A
D
D
G
G-
MTAI
PVARIV
D
ALENPGGKYQHN
GKE
QTYPN
IK
M
IW
-
W
AG
GGN
F
TH
H
Q
D
T
N
R
LIK
A
W
Q
-
-
-
K
P
EMIVV
S
E
C
YW
TA
A
AK
H
ADI
V
LP
ITT
SF
E
RN
DL
T
MTGD
YS
N
Q
-
H
I
V
PM
KQ
A
VA
P
Q
FE
ARNDFD
V
FA
E
L
A
EL
L
K
P
GGKE
I
Y
TEG
K
D
E
MA
WLKF
F
Y
DAAQKG
AR
AQ
R
V
T
MP
M
F
N
A
F
W
QQ
NK
L
IEMR
R
S
E
K
NE
Q
YV
R
Y
G
D
FR
A
DP
V
K
N
A
L
G
TPSGKIEIYS
KT
L
E
K
FGYKDCPAH
P
TW
--
-
---
-
L
A
P
--
-
-
---
-
D
E
W
K
G
T
A
D
E
K
-
Q
LQL
L
TA
H
PA
H
R
L
HS
Q
LNYA
Q
L
R
K
K
YAV
A
D
R
EPIT
I
HTE
DA
A
R
F
GIANGD
L
VRV
W
N
K
RG
Q
IL
TG
A
V
VT
DG
I
KK
GV
V
C
V
HE
GAW
P
D
L
E
-
-
-
N
G
L
CKN
GS
A
N
V
LTA
D
I
PS
SQ
LA
NACA
G
N
S
A
LV
Y
IEKYTGNAPKLTAFDQPAVQA
fig|444452.5.peg.1019
Escherichia coli O157:H7 str. EC4113
MT
LT
RR
E
F
IK
H
S
G
I
AAG
AL
-
---
-
-
---
-
--
V
V
T
S
AAP
LP
AW
A
E
EK
-
--
G
G
K
I
LTA
G
RWG
A
MNVE
VKD
GK
I
-
---
V
S
STG
A
-
-
-
-
LAKTIPNS
L
QSTAADQVHTTA
RI
Q
HP
MVRKSY
L
D
N
P
LQPAKG
RGE
DTYVQV
SW
EQ
AL
KL
I
HEQ
H
E
RI
R
K
A
N
G
PS
A
I
F
--
-
-
AG
SY
G
WR
S
S
G
V
LHK
A
QT
L
LQ
R
Y
MN
LA
GG
Y
S
GH
S
G
D
YST
GAAQ
V
I
MP
H
VV
GS
VEVYEQQTSW
P
L
IL
ENS
QV
VV
LW
G
M
NP
LN
T
LKIAWSSTDEQ
GL
E
Y
F-
-
H
QLK
KS
GK
P
V
I
A
IDP
IR
S
E
T
IEFF
G
Y
NAT
W
IAPNM
GTD
V
AL
ML
GIA
HT
L
M
T
QG
K
H
D
KV
FL
E
KY
TT
GY
PQ
-----
-
--
-
-
-
-
FEE
Y
LT
G
KS
-
D
N
T
P
K
SA
A
W
T
AEITG
V
P
EA
QI
V
KLA
-
E
LM
AA
NRTMLMA
GWG
I
QRQ
Q
Y
GEQ
K
H
WMLVT
L
AA
ML
G
QI
G
T
P
GG
GF
G
FSYHYSNGGNP
T
R
V
G
GV----
-
-
LP
E
M
S
AAIAG
Q
A
S
-
-
-
--
E
A
A
D
D
G
G-
MTAI
PVARIV
D
ALENPGGKYQHN
GKE
QTYPN
IK
M
IW
-
W
AG
GGN
F
TH
H
Q
D
T
N
R
LIK
A
W
Q
-
-
-
K
P
EMIVV
S
E
C
YW
TA
A
AK
H
ADI
V
LP
ITT
SF
E
RN
DL
T
MTGD
YS
N
Q
-
H
I
V
PM
KQ
A
VA
P
Q
FE
ARNDFD
V
FA
E
L
A
EL
L
K
P
GGKE
I
Y
TEG
K
D
E
MA
WLKF
F
Y
DAAQKG
AR
AQ
R
V
T
MP
M
F
N
A
F
W
QQ
NK
L
IEMR
R
S
E
K
NE
Q
YV
R
Y
G
D
FR
A
DP
V
K
N
A
L
G
TPSGKIEIYS
KT
L
E
K
FGYKDCPAH
P
TW
--
-
---
-
L
A
P
--
-
-
---
-
D
E
W
K
G
T
A
D
E
K
-
Q
LQL
L
TA
H
PA
H
R
L
HS
Q
LNYA
Q
L
R
K
K
YAV
A
D
R
EPIT
I
HTE
DA
A
R
F
GIANGD
L
VRV
W
N
K
RG
Q
IL
TG
A
V
VT
DG
I
KK
GV
V
C
V
HE
GAW
P
D
L
E
-
-
-
N
G
L
CKN
GS
A
N
V
LTA
D
I
PS
SQ
LA
NACA
G
N
S
A
LV
Y
IEKYTGNAPKLTAFDQPAVQA
fig|444450.8.peg.2642
Escherichia coli O157:H7 str. EC4115
MT
LT
RR
E
F
IK
H
S
G
I
AAG
AL
-
---
-
-
---
-
--
V
V
T
S
AAP
LP
AW
A
E
EK
-
--
G
G
K
I
LTA
G
RWG
A
MNVE
VKD
GK
I
-
---
V
S
STG
A
-
-
-
-
LAKTIPNS
L
QSTAADQVHTTA
RI
Q
HP
MVRKSY
L
D
N
P
LQPAKG
RGE
DTYVQV
SW
EQ
AL
KL
I
HEQ
H
E
RI
R
K
A
N
G
PS
A
I
F
--
-
-
AG
SY
G
WR
S
S
G
V
LHK
A
QT
L
LQ
R
Y
MN
LA
GG
Y
S
GH
S
G
D
YST
GAAQ
V
I
MP
H
VV
GS
VEVYEQQTSW
P
L
IL
ENS
QV
VV
LW
G
M
NP
LN
T
LKIAWSSTDEQ
GL
E
Y
F-
-
H
QLK
KS
GK
P
V
I
A
IDP
IR
S
E
T
IEFF
G
Y
NAT
W
IAPNM
GTD
V
AL
ML
GIA
HT
L
M
T
QG
K
H
D
KV
FL
E
KY
TT
GY
PQ
-----
-
--
-
-
-
-
FEE
Y
LT
G
KS
-
D
N
T
P
K
SA
A
W
T
AEITG
V
P
EA
QI
V
KLA
-
E
LM
AA
NRTMLMA
GWG
I
QRQ
Q
Y
GEQ
K
H
WMLVT
L
AA
ML
G
QI
G
T
P
GG
GF
G
FSYHYSNGGNP
T
R
V
G
GV----
-
-
LP
E
M
S
AAIAG
Q
A
S
-
-
-
--
E
A
A
D
D
G
G-
MTAI
PVARIV
D
ALENPGGKYQHN
GKE
QTYPN
IK
M
IW
-
W
AG
GGN
F
TH
H
Q
D
T
N
R
LIK
A
W
Q
-
-
-
K
P
EMIVV
S
E
C
YW
TA
A
AK
H
ADI
V
LP
ITT
SF
E
RN
DL
T
MTGD
YS
N
Q
-
H
I
V
PM
KQ
A
VA
P
Q
FE
ARNDFD
V
FA
E
L
A
EL
L
K
P
GGKE
I
Y
TEG
K
D
E
MA
WLKF
F
Y
DAAQKG
AR
AQ
R
V
T
MP
M
F
N
A
F
W
QQ
NK
L
IEMR
R
S
E
K
NE
Q
YV
R
Y
G
D
FR
A
DP
V
K
N
A
L
G
TPSGKIEIYS
KT
L
E
K
FGYKDCPAH
P
TW
--
-
---
-
L
A
P
--
-
-
---
-
D
E
W
K
G
T
A
D
E
K
-
Q
LQL
L
TA
H
PA
H
R
L
HS
Q
LNYA
Q
L
R
K
K
YAV
A
D
R
EPIT
I
HTE
DA
A
R
F
GIANGD
L
VRV
W
N
K
RG
Q
IL
TG
A
V
VT
DG
I
KK
GV
V
C
V
HE
GAW
P
D
L
E
-
-
-
N
G
L
CKN
GS
A
N
V
LTA
D
I
PS
SQ
LA
NACA
G
N
S
A
LV
Y
IEKYTGNAPKLTAFDQPAVQA
fig|444451.5.peg.4077
Escherichia coli O157:H7 str. EC4196
MT
LT
RR
E
F
IK
H
S
G
I
AAG
AL
-
---
-
-
---
-
--
V
V
T
S
AAP
LP
AW
A
E
EK
-
--
G
G
K
I
LTA
G
RWG
A
MNVE
VKD
GK
I
-
---
V
S
STG
A
-
-
-
-
LAKTIPNS
L
QSTAADQVHTTA
RI
Q
HP
MVRKSY
L
D
N
P
LQPAKG
RGE
DTYVQV
SW
EQ
AL
KL
I
HEQ
H
E
RI
R
K
A
N
G
PS
A
I
F
--
-
-
AG
SY
G
WR
S
S
G
V
LHK
A
QT
L
LQ
R
Y
MN
LA
GG
Y
S
GH
S
G
D
YST
GAAQ
V
I
MP
H
VV
GS
VEVYEQQTSW
P
L
IL
ENS
QV
VV
LW
G
M
NP
LN
T
LKIAWSSTDEQ
GL
E
Y
F-
-
H
QLK
KS
GK
P
V
I
A
IDP
IR
S
E
T
IEFF
G
Y
NAT
W
IAPNM
GTD
V
AL
ML
GIA
HT
L
M
T
QG
K
H
D
KV
FL
E
KY
TT
GY
PQ
-----
-
--
-
-
-
-
FEE
Y
LT
G
KS
-
D
N
T
P
K
SA
A
W
T
AEITG
V
P
EA
QI
V
KLA
-
E
LM
AA
NRTMLMA
GWG
I
QRQ
Q
Y
GEQ
K
H
WMLVT
L
AA
ML
G
QI
G
T
P
GG
GF
G
FSYHYSNGGNP
T
R
V
G
GV----
-
-
LP
E
M
S
AAIAG
Q
A
S
-
-
-
--
E
A
A
D
D
G
G-
MTAI
PVARIV
D
ALENPGGKYQHN
GKE
QTYPN
IK
M
IW
-
W
AG
GGN
F
TH
H
Q
D
T
N
R
LIK
A
W
Q
-
-
-
K
P
EMIVV
S
E
C
YW
TA
A
AK
H
ADI
V
LP
ITT
SF
E
RN
DL
T
MTGD
YS
N
Q
-
H
I
V
PM
KQ
A
VA
P
Q
FE
ARNDFD
V
FA
E
L
A
EL
L
K
P
GGKE
I
Y
TEG
K
D
E
MA
WLKF
F
Y
DAAQKG
AR
AQ
R
V
T
MP
M
F
N
A
F
W
QQ
NK
L
IEMR
R
S
E
K
NE
Q
YV
R
Y
G
D
FR
A
DP
V
K
N
A
L
G
TPSGKIEIYS
KT
L
E
K
FGYKDCPAH
P
TW
--
-
---
-
L
A
P
--
-
-
---
-
D
E
W
K
G
T
A
D
E
K
-
Q
LQL
L
TA
H
PA
H
R
L
HS
Q
LNYA
Q
L
R
K
K
YAV
A
D
R
EPIT
I
HTE
DA
A
R
F
GIANGD
L
VRV
W
N
K
RG
Q
IL
TG
A
V
VT
DG
I
KK
GV
V
C
V
HE
GAW
P
D
L
E
-
-
-
N
G
L
CKN
GS
A
N
V
LTA
D
I
PS
SQ
LA
NACA
G
N
S
A
LV
Y
IEKYTGNAPKLTAFDQPAVQA
fig|444447.5.peg.4856
Escherichia coli O157:H7 str. EC4206
MT
LT
RR
E
F
IK
H
S
G
I
AAG
AL
-
---
-
-
---
-
--
V
V
T
S
AAP
LP
AW
A
E
EK
-
--
G
G
K
I
LTA
G
RWG
A
MNVE
VKD
GK
I
-
---
V
S
STG
A
-
-
-
-
LAKTIPNS
L
QSTAADQVHTTA
RI
Q
HP
MVRKSY
L
D
N
P
LQPAKG
RGE
DTYVQV
SW
EQ
AL
KL
I
HEQ
H
E
RI
R
K
A
N
G
PS
A
I
F
--
-
-
AG
SY
G
WR
S
S
G
V
LHK
A
QT
L
LQ
R
Y
MN
LA
GG
Y
S
GH
S
G
D
YST
GAAQ
V
I
MP
H
VV
GS
VEVYEQQTSW
P
L
IL
ENS
QV
VV
LW
G
M
NP
LN
T
LKIAWSSTDEQ
GL
E
Y
F-
-
H
QLK
KS
GK
P
V
I
A
IDP
IR
S
E
T
IEFF
G
Y
NAT
W
IAPNM
GTD
V
AL
ML
GIA
HT
L
M
T
QG
K
H
D
KV
FL
E
KY
TT
GY
PQ
-----
-
--
-
-
-
-
FEE
Y
LT
G
KS
-
D
N
T
P
K
SA
A
W
T
AEITG
V
P
EA
QI
V
KLA
-
E
LM
AA
NRTMLMA
GWG
I
QRQ
Q
Y
GEQ
K
H
WMLVT
L
AA
ML
G
QI
G
T
P
GG
GF
G
FSYHYSNGGNP
T
R
V
G
GV----
-
-
LP
E
M
S
AAIAG
Q
A
S
-
-
-
--
E
A
A
D
D
G
G-
MTAI
PVARIV
D
ALENPGGKYQHN
GKE
QTYPN
IK
M
IW
-
W
AG
GGN
F
TH
H
Q
D
T
N
R
LIK
A
W
Q
-
-
-
K
P
EMIVV
S
E
C
YW
TA
A
AK
H
ADI
V
LP
ITT
SF
E
RN
DL
T
MTGD
YS
N
Q
-
H
I
V
PM
KQ
A
VA
P
Q
FE
ARNDFD
V
FA
E
L
A
EL
L
K
P
GGKE
I
Y
TEG
K
D
E
MA
WLKF
F
Y
DAAQKG
AR
AQ
R
V
T
MP
M
F
N
A
F
W
QQ
NK
L
IEMR
R
S
E
K
NE
Q
YV
R
Y
G
D
FR
A
DP
V
K
N
A
L
G
TPSGKIEIYS
KT
L
E
K
FGYKDCPAH
P
TW
--
-
---
-
L
A
P
--
-
-
---
-
D
E
W
K
G
T
A
D
E
K
-
Q
LQL
L
TA
H
PA
H
R
L
HS
Q
LNYA
Q
L
R
K
K
YAV
A
D
R
EPIT
I
HTE
DA
A
R
F
GIANGD
L
VRV
W
N
K
RG
Q
IL
TG
A
V
VT
DG
I
KK
GV
V
C
V
HE
GAW
P
D
L
E
-
-
-
N
G
L
CKN
GS
A
N
V
LTA
D
I
PS
SQ
LA
NACA
G
N
S
A
LV
Y
IEKYTGNAPKLTAFDQPAVQA
fig|478004.5.peg.4518
Escherichia coli O157:H7 str. EC4401
MT
LT
RR
E
F
IK
H
S
G
I
AAG
AL
-
---
-
-
---
-
--
V
V
T
S
AAP
LP
AW
A
E
EK
-
--
G
G
K
I
LTA
G
RWG
A
MNVE
VKD
GK
I
-
---
V
S
STG
A
-
-
-
-
LAKTIPNS
L
QSTAADQVHTTA
RI
Q
HP
MVRKSY
L
D
N
P
LQPAKG
RGE
DTYVQV
SW
EQ
AL
KL
I
HEQ
H
E
RI
R
K
A
N
G
PS
A
I
F
--
-
-
AG
SY
G
WR
S
S
G
V
LHK
A
QT
L
LQ
R
Y
MN
LA
GG
Y
S
GH
S
G
D
YST
GAAQ
V
I
MP
H
VV
GS
VEVYEQQTSW
P
L
IL
ENS
QV
VV
LW
G
M
NP
LN
T
LKIAWSSTDEQ
GL
E
Y
F-
-
H
QLK
KS
GK
P
V
I
A
IDP
IR
S
E
T
IEFF
G
Y
NAT
W
IAPNM
GTD
V
AL
ML
GIA
HT
L
M
T
QG
K
H
D
KV
FL
E
KY
TT
GY
PQ
-----
-
--
-
-
-
-
FEE
Y
LT
G
KS
-
D
N
T
P
K
SA
A
W
T
AEITG
V
P
EA
QI
V
KLA
-
E
LM
AA
NRTMLMA
GWG
I
QRQ
Q
Y
GEQ
K
H
WMLVT
L
AA
ML
G
QI
G
T
P
GG
GF
G
FSYHYSNGGNP
T
R
V
G
GV----
-
-
LP
E
M
S
AAIAG
Q
A
S
-
-
-
--
E
A
A
D
D
G
G-
MTAI
PVARIV
D
ALENPGGKYQHN
GKE
QTYPN
IK
M
IW
-
W
AG
GGN
F
TH
H
Q
D
T
N
R
LIK
A
W
Q
-
-
-
K
P
EMIVV
S
E
C
YW
TA
A
AK
H
ADI
V
LP
ITT
SF
E
RN
DL
T
MTGD
YS
N
Q
-
H
I
V
PM
KQ
A
VA
P
Q
FE
ARNDFD
V
FA
E
L
A
EL
L
K
P
GGKE
I
Y
TEG
K
D
E
MA
WLKF
F
Y
DAAQKG
AR
AQ
R
V
T
MP
M
F
N
A
F
W
QQ
NK
L
IEMR
R
S
E
K
NE
Q
YV
R
Y
G
D
FR
A
DP
V
K
N
A
L
G
TPSGKIEIYS
KT
L
E
K
FGYKDCPAH
P
TW
--
-
---
-
L
A
P
--
-
-
---
-
D
E
W
K
G
T
A
D
E
K
-
Q
LQL
L
TA
H
PA
H
R
L
HS
Q
LNYA
Q
L
R
K
K
YAV
A
D
R
EPIT
I
HTE
DA
A
R
F
GIANGD
L
VRV
W
N
K
RG
Q
IL
TG
A
V
VT
DG
I
KK
GV
V
C
V
HE
GAW
P
D
L
E
-
-
-
N
G
L
CKN
GS
A
N
V
LTA
D
I
PS
SQ
LA
NACA
G
N
S
A
LV
Y
IEKYTGNAPKLTAFDQPAVQA
fig|478006.5.peg.2783
Escherichia coli O157:H7 str. EC4501
MT
LT
RR
E
F
IK
H
S
G
I
AAG
AL
-
---
-
-
---
-
--
V
V
T
S
AAP
LP
AW
A
E
EK
-
--
G
G
K
I
LTA
G
RWG
A
MNVE
VKD
GK
I
-
---
V
S
STG
A
-
-
-
-
LAKTIPNS
L
QSTAADQVHTTA
RI
Q
HP
MVRKSY
L
D
N
P
LQPAKG
RGE
DTYVQV
SW
EQ
AL
KL
I
HEQ
H
E
RI
R
K
A
N
G
PS
A
I
F
--
-
-
AG
SY
G
WR
S
S
G
V
LHK
A
QT
L
LQ
R
Y
MN
LA
GG
Y
S
GH
S
G
D
YST
GAAQ
V
I
MP
H
VV
GS
VEVYEQQTSW
P
L
IL
ENS
QV
VV
LW
G
M
NP
LN
T
LKIAWSSTDEQ
GL
E
Y
F-
-
H
QLK
KS
GK
P
V
I
A
IDP
IR
S
E
T
IEFF
G
Y
NAT
W
IAPNM
GTD
V
AL
ML
GIA
HT
L
M
T
QG
K
H
D
KV
FL
E
KY
TT
GY
PQ
-----
-
--
-
-
-
-
FEE
Y
LT
G
KS
-
D
N
T
P
K
SA
A
W
T
AEITG
V
P
EA
QI
V
KLA
-
E
LM
AA
NRTMLMA
GWG
I
QRQ
Q
Y
GEQ
K
H
WMLVT
L
AA
ML
G
QI
G
T
P
GG
GF
G
FSYHYSNGGNP
T
R
V
G
GV----
-
-
LP
E
M
S
AAIAG
Q
A
S
-
-
-
--
E
A
A
D
D
G
G-
MTAI
PVARIV
D
ALENPGGKYQHN
GKE
QTYPN
IK
M
IW
-
W
AG
GGN
F
TH
H
Q
D
T
N
R
LIK
A
W
Q
-
-
-
K
P
EMIVV
S
E
C
YW
TA
A
AK
H
ADI
V
LP
ITT
SF
E
RN
DL
T
MTGD
YS
N
Q
-
H
I
V
PM
KQ
A
VA
P
Q
FE
ARNDFD
V
FA
E
L
A
EL
L
K
P
GGKE
I
Y
TEG
K
D
E
MA
WLKF
F
Y
DAAQKG
AR
AQ
R
V
T
MP
M
F
N
A
F
W
QQ
NK
L
IEMR
R
S
E
K
NE
Q
YV
R
Y
G
D
FR
A
DP
V
K
N
A
L
G
TPSGKIEIYS
KT
L
E
K
FGYKDCPAH
P
TW
--
-
---
-
L
A
P
--
-
-
---
-
D
E
W
K
G
T
A
D
E
K
-
Q
LQL
L
TA
H
PA
H
R
L
HS
Q
LNYA
Q
L
R
K
K
YAV
A
D
R
EPIT
I
HTE
DA
A
R
F
GIANGD
L
VRV
W
N
K
RG
Q
IL
TG
A
V
VT
DG
I
KK
GV
V
C
V
HE
GAW
P
D
L
E
-
-
-
N
G
L
CKN
GS
A
N
V
LTA
D
I
PS
SQ
LA
NACA
G
N
S
A
LV
Y
IEKYTGNAPKLTAFDQPAVQA
fig|478007.5.peg.4494
Escherichia coli O157:H7 str. EC508
MT
LT
RR
E
F
IK
H
S
G
I
AAG
AL
-
---
-
-
---
-
--
V
V
T
S
AAP
LP
AW
A
E
EK
-
--
G
G
K
I
LTA
G
RWG
A
MNVE
VKD
GK
I
-
---
V
S
STG
A
-
-
-
-
LAKTIPNS
L
QSTAADQVHTTA
RI
Q
HP
MVRKSY
L
D
N
P
LQPAKG
RGE
DTYVQV
SW
EQ
AL
KL
I
HEQ
H
E
RI
R
K
A
N
G
PS
A
I
F
--
-
-
AG
SY
G
WR
S
S
G
V
LHK
A
QT
L
LQ
R
Y
MN
LA
GG
Y
S
GH
S
G
D
YST
GAAQ
V
I
MP
H
VV
GS
VEVYEQQTSW
P
L
IL
ENS
QV
VV
LW
G
M
NP
LN
T
LKIAWSSTDEQ
GL
E
Y
F-
-
H
QLK
KS
GK
P
V
I
A
IDP
IR
S
E
T
IEFF
G
Y
NAT
W
IAPNM
GTD
V
AL
ML
GIA
HT
L
M
T
QG
K
H
D
KV
FL
E
KY
TT
GY
PQ
-----
-
--
-
-
-
-
FEE
Y
LT
G
KS
-
D
N
T
P
K
SA
A
W
T
AEITG
V
P
EA
QI
V
KLA
-
E
LM
AA
NRTMLMA
GWG
I
QRQ
Q
Y
GEQ
K
H
WMLVT
L
AA
ML
G
QI
G
T
P
GG
GF
G
FSYHYSNGGNP
T
R
V
G
GV----
-
-
LP
E
M
S
AAIAG
Q
A
S
-
-
-
--
E
A
A
D
D
G
G-
MTAI
PVARIV
D
ALENPGGKYQHN
GKE
QTYPN
IK
M
IW
-
W
AG
GGN
F
TH
H
Q
D
T
N
R
LIK
A
W
Q
-
-
-
K
P
EMIVV
S
E
C
YW
TA
A
AK
H
ADI
V
LP
ITT
SF
E
RN
DL
T
MTGD
YS
N
Q
-
H
I
V
PM
KQ
A
VA
P
Q
FE
ARNDFD
V
FA
E
L
A
EL
L
K
P
GGKE
I
Y
TEG
K
D
E
MA
WLKF
F
Y
DAAQKG
AR
AQ
R
V
T
MP
M
F
N
A
F
W
QQ
NK
L
IEMR
R
S
E
K
NE
Q
YV
R
Y
G
D
FR
A
DP
V
K
N
A
L
G
TPSGKIEIYS
KT
L
E
K
FGYKDCPAH
P
TW
--
-
---
-
L
A
P
--
-
-
---
-
D
E
W
K
G
T
A
D
E
K
-
Q
LQL
L
TA
H
PA
H
R
L
HS
Q
LNYA
Q
L
R
K
K
YAV
A
D
R
EPIT
I
HTE
DA
A
R
F
GIANGD
L
VRV
W
N
K
RG
Q
IL
TG
A
V
VT
DG
I
KK
GV
V
C
V
HE
GAW
P
D
L
E
-
-
-
N
G
L
CKN
GS
A
N
V
LTA
D
I
PS
SQ
LA
NACA
G
N
S
A
LV
Y
IEKYTGNAPKLTAFDQPAVQA
fig|478008.5.peg.4786
Escherichia coli O157:H7 str. EC869
MT
LT
RR
E
F
IK
H
S
G
I
AAG
AL
-
---
-
-
---
-
--
V
V
T
S
AAP
LP
AW
A
E
EK
-
--
G
G
K
I
LTA
G
RWG
A
MNVE
VKD
GK
I
-
---
V
S
STG
A
-
-
-
-
LAKTIPNS
L
QSTAADQVHTTA
RI
Q
HP
MVRKSY
L
D
N
P
LQPAKG
RGE
DTYVQV
SW
EQ
AL
KL
I
HEQ
H
E
RI
R
K
A
N
G
PS
A
I
F
--
-
-
AG
SY
G
WR
S
S
G
V
LHK
A
QT
L
LQ
R
Y
MN
LA
GG
Y
S
GH
S
G
D
YST
GAAQ
V
I
MP
H
VV
GS
VEVYEQQTSW
P
L
IL
ENS
QV
VV
LW
G
M
NP
LN
T
LKIAWSSTDEQ
GL
E
Y
F-
-
H
QLK
KS
GK
P
V
I
A
IDP
IR
S
E
T
IEFF
G
Y
NAT
W
IAPNM
GTD
V
AL
ML
GIA
HT
L
M
T
QG
K
H
D
KV
FL
E
KY
TT
GY
PQ
-----
-
--
-
-
-
-
FEE
Y
LT
G
KS
-
D
N
T
P
K
SA
A
W
T
AEITG
V
P
EA
QI
V
KLA
-
E
LM
AA
NRTMLMA
GWG
I
QRQ
Q
Y
GEQ
K
H
WMLVT
L
AA
ML
G
QI
G
T
P
GG
GF
G
FSYHYSNGGNP
T
R
V
G
GV----
-
-
LP
E
M
S
AAIAG
Q
A
S
-
-
-
--
E
A
A
D
D
G
G-
MTAI
PVARIV
D
ALENPGGKYQHN
GKE
QTYPN
IK
M
IW
-
W
AG
GGN
F
TH
H
Q
D
T
N
R
LIK
A
W
Q
-
-
-
K
P
EMIVV
S
E
C
YW
TA
A
AK
H
ADI
V
LP
ITT
SF
E
RN
DL
T
MTGD
YS
N
Q
-
H
I
V
PM
KQ
A
VA
P
Q
FE
ARNDFD
V
FA
E
L
A
EL
L
K
P
GGKE
I
Y
TEG
K
D
E
MA
WLKF
F
Y
DAAQKG
AR
AQ
R
V
T
MP
M
F
N
A
F
W
QQ
NK
L
IEMR
R
S
E
K
NE
Q
YV
R
Y
G
D
FR
A
DP
V
K
N
A
L
G
TPSGKIEIYS
KT
L
E
K
FGYKDCPAH
P
TW
--
-
---
-
L
A
P
--
-
-
---
-
D
E
W
K
G
T
A
D
E
K
-
Q
LQL
L
TA
H
PA
H
R
L
HS
Q
LNYA
Q
L
R
K
K
YAV
A
D
R
EPIT
I
HTE
DA
A
R
F
GIANGD
L
VRV
W
N
K
RG
Q
IL
TG
A
V
VT
DG
I
KK
GV
V
C
V
HE
GAW
P
D
L
E
-
-
-
N
G
L
CKN
GS
A
N
V
LTA
D
I
PS
SQ
LA
NACA
G
N
S
A
LV
Y
IEKYTGNAPKLTAFDQPAVQA
fig|637388.3.peg.4708
Escherichia coli O157:H7 str. FRIK2000
MT
LT
RR
E
F
IK
H
S
G
I
AAG
AL
-
---
-
-
---
-
--
V
V
T
S
AAP
LP
AW
A
E
EK
-
--
G
G
K
I
LTA
G
RWG
A
MNVE
VKD
GK
I
-
---
V
S
STG
A
-
-
-
-
LAKTIPNS
L
QSTAADQVHTTA
RI
Q
HP
MVRKSY
L
D
N
P
LQPAKG
RGE
DTYVQV
SW
EQ
AL
KL
I
HEQ
H
E
RI
R
K
A
N
G
PS
A
I
F
--
-
-
AG
SY
G
WR
S
S
G
V
LHK
A
QT
L
LQ
R
Y
MN
LA
GG
Y
S
GH
S
G
D
YST
GAAQ
V
I
MP
H
VV
GS
VEVYEQQTSW
P
L
IL
ENS
QV
VV
LW
G
M
NP
LN
T
LKIAWSSTDEQ
GL
E
Y
F-
-
H
QLK
KS
GK
P
V
I
A
IDP
IR
S
E
T
IEFF
G
Y
NAT
W
IAPNM
GTD
V
AL
ML
GIA
HT
L
M
T
QG
K
H
D
KV
FL
E
KY
TT
GY
PQ
-----
-
--
-
-
-
-
FEE
Y
LT
G
KS
-
D
N
T
P
K
SA
A
W
T
AEITG
V
P
EA
QI
V
KLA
-
E
LM
AA
NRTMLMA
GWG
I
QRQ
Q
Y
GEQ
K
H
WMLVT
L
AA
ML
G
QI
G
T
P
GG
GF
G
FSYHYSNGGNP
T
R
V
G
GV----
-
-
LP
E
M
S
AAIAG
Q
A
S
-
-
-
--
E
A
A
D
D
G
G-
MTAI
PVARIV
D
ALENPGGKYQHN
GKE
QTYPN
IK
M
IW
-
W
AG
GGN
F
TH
H
Q
D
T
N
R
LIK
A
W
Q
-
-
-
K
P
EMIVV
S
E
C
YW
TA
A
AK
H
ADI
V
LP
ITT
SF
E
RN
DL
T
MTGD
YS
N
Q
-
H
I
V
PM
KQ
A
VA
P
Q
FE
ARNDFD
V
FA
E
L
A
EL
L
K
P
GGKE
I
Y
TEG
K
D
E
MA
WLKF
F
Y
DAAQKG
AR
AQ
R
V
T
MP
M
F
N
A
F
W
QQ
NK
L
IEMR
R
S
E
K
NE
Q
YV
R
Y
G
D
FR
A
DP
V
K
N
A
L
G
TPSGKIEIYS
KT
L
E
K
FGYKDCPAH
P
TW
--
-
---
-
L
A
P
--
-
-
---
-
D
E
W
K
G
T
A
D
E
K
-
Q
LQL
L
TA
H
PA
H
R
L
HS
Q
LNYA
Q
L
R
K
K
YAV
A
D
R
EPIT
I
HTE
DA
A
R
F
GIANGD
L
VRV
W
N
K
RG
Q
IL
TG
A
V
VT
DG
I
KK
GV
V
C
V
HE
GAW
P
D
L
E
-
-
-
N
G
L
CKN
GS
A
N
V
LTA
D
I
PS
SQ
LA
NACA
G
N
S
A
LV
Y
IEKYTGNAPKLTAFDQPAVQA
fig|570506.3.peg.4096
Escherichia coli O157:H7 str. FRIK966
MT
LT
RR
E
F
IK
H
S
G
I
AAG
AL
-
---
-
-
---
-
--
V
V
T
S
AAP
LP
AW
A
E
EK
-
--
G
G
K
I
LTA
G
RWG
A
MNVE
VKD
GK
I
-
---
V
S
STG
A
-
-
-
-
LAKTIPNS
L
QSTAADQVHTTA
RI
Q
HP
MVRKSY
L
D
N
P
LQPAKG
RGE
DTYVQV
SW
EQ
AL
KL
I
HEQ
H
E
RI
R
K
A
N
G
PS
A
I
F
--
-
-
AG
SY
G
WR
S
S
G
V
LHK
A
QT
L
LQ
R
Y
MN
LA
GG
Y
S
GH
S
G
D
YST
GAAQ
V
I
MP
H
VV
GS
VEVYEQQTSW
P
L
IL
ENS
QV
VV
LW
G
M
NP
LN
T
LKIAWSSTDEQ
GL
E
Y
F-
-
H
QLK
KS
GK
P
V
I
A
IDP
IR
S
E
T
IEFF
G
Y
NAT
W
IAPNM
GTD
V
AL
ML
GIA
HT
L
M
T
QG
K
H
D
KV
FL
E
KY
TT
GY
PQ
-----
-
--
-
-
-
-
FEE
Y
LT
G
KS
-
D
N
T
P
K
SA
A
W
T
AEITG
V
P
EA
QI
V
KLA
-
E
LM
AA
NRTMLMA
GWG
I
QRQ
Q
Y
GEQ
K
H
WMLVT
L
AA
ML
G
QI
G
T
P
GG
GF
G
FSYHYSNGGNP
T
R
V
G
GV----
-
-
LP
E
M
S
AAIAG
Q
A
S
-
-
-
--
E
A
A
D
D
G
G-
MTAI
PVARIV
D
ALENPGGKYQHN
GKE
QTYPN
IK
M
IW
-
W
AG
GGN
F
TH
H
Q
D
T
N
R
LIK
A
W
Q
-
-
-
K
P
EMIVV
S
E
C
YW
TA
A
AK
H
ADI
V
LP
ITT
SF
E
RN
DL
T
MTGD
YS
N
Q
-
H
I
V
PM
KQ
A
VA
P
Q
FE
ARNDFD
V
FA
E
L
A
EL
L
K
P
GGKE
I
Y
TEG
K
D
E
MA
WLKF
F
Y
DAAQKG
AR
AQ
R
V
T
MP
M
F
N
A
F
W
QQ
NK
L
IEMR
R
S
E
K
NE
Q
YV
R
Y
G
D
FR
A
DP
V
K
N
A
L
G
TPSGKIEIYS
KT
L
E
K
FGYKDCPAH
P
TW
--
-
---
-
L
A
P
--
-
-
---
-
D
E
W
K
G
T
A
D
E
K
-
Q
LQL
L
TA
H
PA
H
R
L
HS
Q
LNYA
Q
L
R
K
K
YAV
A
D
R
EPIT
I
HTE
DA
A
R
F
GIANGD
L
VRV
W
N
K
RG
Q
IL
TG
A
V
VT
DG
I
KK
GV
V
C
V
HE
GAW
P
D
L
E
-
-
-
N
G
L
CKN
GS
A
N
V
LTA
D
I
PS
SQ
LA
NACA
G
N
S
A
LV
Y
IEKYTGNAPKLTAFDQPAVQA
fig|386585.9.peg.2707
Escherichia coli O157:H7 str. Sakai
MT
LT
RR
E
F
IK
H
S
G
I
AAG
AL
-
---
-
-
---
-
--
V
V
T
S
AAP
LP
AW
A
E
EK
-
--
G
G
K
I
LTA
G
RWG
A
MNVE
VKD
GK
I
-
---
V
S
STG
A
-
-
-
-
LAKTIPNS
L
QSTAADQVHTTA
RI
Q
HP
MVRKSY
L
D
N
P
LQPAKG
RGE
DTYVQV
SW
EQ
AL
KL
I
HEQ
H
E
RI
R
K
A
N
G
PS
A
I
F
--
-
-
AG
SY
G
WR
S
S
G
V
LHK
A
QT
L
LQ
R
Y
MN
LA
GG
Y
S
GH
S
G
D
YST
GAAQ
V
I
MP
H
VV
GS
VEVYEQQTSW
P
L
IL
ENS
QV
VV
LW
G
M
NP
LN
T
LKIAWSSTDEQ
GL
E
Y
F-
-
H
QLK
KS
GK
P
V
I
A
IDP
IR
S
E
T
IEFF
G
Y
NAT
W
IAPNM
GTD
V
AL
ML
GIA
HT
L
M
T
QG
K
H
D
KV
FL
E
KY
TT
GY
PQ
-----
-
--
-
-
-
-
FEE
Y
LT
G
KS
-
D
N
T
P
K
SA
A
W
T
AEITG
V
P
EA
QI
V
KLA
-
E
LM
AA
NRTMLMA
GWG
I
QRQ
Q
Y
GEQ
K
H
WMLVT
L
AA
ML
G
QI
G
T
P
GG
GF
G
FSYHYSNGGNP
T
R
V
G
GV----
-
-
LP
E
M
S
AAIAG
Q
A
S
-
-
-
--
E
A
A
D
D
G
G-
MTAI
PVARIV
D
ALENPGGKYQHN
GKE
QTYPN
IK
M
IW
-
W
AG
GGN
F
TH
H
Q
D
T
N
R
LIK
A
W
Q
-
-
-
K
P
EMIVV
S
E
C
YW
TA
A
AK
H
ADI
V
LP
ITT
SF
E
RN
DL
T
MTGD
YS
N
Q
-
H
I
V
PM
KQ
A
VA
P
Q
FE
ARNDFD
V
FA
E
L
A
EL
L
K
P
GGKE
I
Y
TEG
K
D
E
MA
WLKF
F
Y
DAAQKG
AR
AQ
R
V
T
MP
M
F
N
A
F
W
QQ
NK
L
IEMR
R
S
E
K
NE
Q
YV
R
Y
G
D
FR
A
DP
V
K
N
A
L
G
TPSGKIEIYS
KT
L
E
K
FGYKDCPAH
P
TW
--
-
---
-
L
A
P
--
-
-
---
-
D
E
W
K
G
T
A
D
E
K
-
Q
LQL
L
TA
H
PA
H
R
L
HS
Q
LNYA
Q
L
R
K
K
YAV
A
D
R
EPIT
I
HTE
DA
A
R
F
GIANGD
L
VRV
W
N
K
RG
Q
IL
TG
A
V
VT
DG
I
KK
GV
V
C
V
HE
GAW
P
D
L
E
-
-
-
N
G
L
CKN
GS
A
N
V
LTA
D
I
PS
SQ
LA
NACA
G
N
S
A
LV
Y
IEKYTGNAPKLTAFDQPAVQA
fig|544404.4.peg.2505
Escherichia coli O157:H7 str. TW14359
MT
LT
RR
E
F
IK
H
S
G
I
AAG
AL
-
---
-
-
---
-
--
V
V
T
S
AAP
LP
AW
A
E
EK
-
--
G
G
K
I
LTA
G
RWG
A
MNVE
VKD
GK
I
-
---
V
S
STG
A
-
-
-
-
LAKTIPNS
L
QSTAADQVHTTA
RI
Q
HP
MVRKSY
L
D
N
P
LQPAKG
RGE
DTYVQV
SW
EQ
AL
KL
I
HEQ
H
E
RI
R
K
A
N
G
PS
A
I
F
--
-
-
AG
SY
G
WR
S
S
G
V
LHK
A
QT
L
LQ
R
Y
MN
LA
GG
Y
S
GH
S
G
D
YST
GAAQ
V
I
MP
H
VV
GS
VEVYEQQTSW
P
L
IL
ENS
QV
VV
LW
G
M
NP
LN
T
LKIAWSSTDEQ
GL
E
Y
F-
-
H
QLK
KS
GK
P
V
I
A
IDP
IR
S
E
T
IEFF
G
Y
NAT
W
IAPNM
GTD
V
AL
ML
GIA
HT
L
M
T
QG
K
H
D
KV
FL
E
KY
TT
GY
PQ
-----
-
--
-
-
-
-
FEE
Y
LT
G
KS
-
D
N
T
P
K
SA
A
W
T
AEITG
V
P
EA
QI
V
KLA
-
E
LM
AA
NRTMLMA
GWG
I
QRQ
Q
Y
GEQ
K
H
WMLVT
L
AA
ML
G
QI
G
T
P
GG
GF
G
FSYHYSNGGNP
T
R
V
G
GV----
-
-
LP
E
M
S
AAIAG
Q
A
S
-
-
-
--
E
A
A
D
D
G
G-
MTAI
PVARIV
D
ALENPGGKYQHN
GKE
QTYPN
IK
M
IW
-
W
AG
GGN
F
TH
H
Q
D
T
N
R
LIK
A
W
Q
-
-
-
K
P
EMIVV
S
E
C
YW
TA
A
AK
H
ADI
V
LP
ITT
SF
E
RN
DL
T
MTGD
YS
N
Q
-
H
I
V
PM
KQ
A
VA
P
Q
FE
ARNDFD
V
FA
E
L
A
EL
L
K
P
GGKE
I
Y
TEG
K
D
E
MA
WLKF
F
Y
DAAQKG
AR
AQ
R
V
T
MP
M
F
N
A
F
W
QQ
NK
L
IEMR
R
S
E
K
NE
Q
YV
R
Y
G
D
FR
A
DP
V
K
N
A
L
G
TPSGKIEIYS
KT
L
E
K
FGYKDCPAH
P
TW
--
-
---
-
L
A
P
--
-
-
---
-
D
E
W
K
G
T
A
D
E
K
-
Q
LQL
L
TA
H
PA
H
R
L
HS
Q
LNYA
Q
L
R
K
K
YAV
A
D
R
EPIT
I
HTE
DA
A
R
F
GIANGD
L
VRV
W
N
K
RG
Q
IL
TG
A
V
VT
DG
I
KK
GV
V
C
V
HE
GAW
P
D
L
E
-
-
-
N
G
L
CKN
GS
A
N
V
LTA
D
I
PS
SQ
LA
NACA
G
N
S
A
LV
Y
IEKYTGNAPKLTAFDQPAVQA
fig|502346.5.peg.4803
Escherichia coli O157:H7 str. TW14588
MT
LT
RR
E
F
IK
H
S
G
I
AAG
AL
-
---
-
-
---
-
--
V
V
T
S
AAP
LP
AW
A
E
EK
-
--
G
G
K
I
LTA
G
RWG
A
MNVE
VKD
GK
I
-
---
V
S
STG
A
-
-
-
-
LAKTIPNS
L
QSTAADQVHTTA
RI
Q
HP
MVRKSY
L
D
N
P
LQPAKG
RGE
DTYVQV
SW
EQ
AL
KL
I
HEQ
H
E
RI
R
K
A
N
G
PS
A
I
F
--
-
-
AG
SY
G
WR
S
S
G
V
LHK
A
QT
L
LQ
R
Y
MN
LA
GG
Y
S
GH
S
G
D
YST
GAAQ
V
I
MP
H
VV
GS
VEVYEQQTSW
P
L
IL
ENS
QV
VV
LW
G
M
NP
LN
T
LKIAWSSTDEQ
GL
E
Y
F-
-
H
QLK
KS
GK
P
V
I
A
IDP
IR
S
E
T
IEFF
G
Y
NAT
W
IAPNM
GTD
V
AL
ML
GIA
HT
L
M
T
QG
K
H
D
KV
FL
E
KY
TT
GY
PQ
-----
-
--
-
-
-
-
FEE
Y
LT
G
KS
-
D
N
T
P
K
SA
A
W
T
AEITG
V
P
EA
QI
V
KLA
-
E
LM
AA
NRTMLMA
GWG
I
QRQ
Q
Y
GEQ
K
H
WMLVT
L
AA
ML
G
QI
G
T
P
GG
GF
G
FSYHYSNGGNP
T
R
V
G
GV----
-
-
LP
E
M
S
AAIAG
Q
A
S
-
-
-
--
E
A
A
D
D
G
G-
MTAI
PVARIV
D
ALENPGGKYQHN
GKE
QTYPN
IK
M
IW
-
W
AG
GGN
F
TH
H
Q
D
T
N
R
LIK
A
W
Q
-
-
-
K
P
EMIVV
S
E
C
YW
TA
A
AK
H
ADI
V
LP
ITT
SF
E
RN
DL
T
MTGD
YS
N
Q
-
H
I
V
PM
KQ
A
VA
P
Q
FE
ARNDFD
V
FA
E
L
A
EL
L
K
P
GGKE
I
Y
TEG
K
D
E
MA
WLKF
F
Y
DAAQKG
AR
AQ
R
V
T
MP
M
F
N
A
F
W
QQ
NK
L
IEMR
R
S
E
K
NE
Q
YV
R
Y
G
D
FR
A
DP
V
K
N
A
L
G
TPSGKIEIYS
KT
L
E
K
FGYKDCPAH
P
TW
--
-
---
-
L
A
P
--
-
-
---
-
D
E
W
K
G
T
A
D
E
K
-
Q
LQL
L
TA
H
PA
H
R
L
HS
Q
LNYA
Q
L
R
K
K
YAV
A
D
R
EPIT
I
HTE
DA
A
R
F
GIANGD
L
VRV
W
N
K
RG
Q
IL
TG
A
V
VT
DG
I
KK
GV
V
C
V
HE
GAW
P
D
L
E
-
-
-
N
G
L
CKN
GS
A
N
V
LTA
D
I
PS
SQ
LA
NACA
G
N
S
A
LV
Y
IEKYTGNAPKLTAFDQPAVQA
fig|749538.3.peg.4492
Escherichia coli MS 116-1
MT
LT
RR
E
F
IK
H
S
G
I
AAG
AL
-
---
-
-
---
-
--
V
V
T
S
AAP
LP
AW
A
E
EK
-
--
G
G
K
I
LTA
G
RWG
A
MNVE
VKD
GK
I
-
---
V
S
STG
A
-
-
-
-
LAKTIPNS
L
QSTAADQVHTTA
RI
Q
HP
MVRKSY
L
D
N
P
LQPAKG
RGE
DTYVQV
SW
EQ
AL
KL
I
HEQ
H
D
RI
R
K
A
N
G
PS
A
I
F
--
-
-
AG
SY
G
WR
S
S
G
V
LHK
A
QT
L
LQ
R
Y
MN
LA
GG
Y
S
GH
S
G
D
YST
GAAQ
V
I
MP
H
VV
GS
VEVYEQQTSW
P
L
IL
ENS
QV
VV
LW
G
M
NP
LN
T
LKIAWSSTDEQ
GL
E
Y
F-
-
H
QLK
KS
GK
P
V
I
A
IDP
IR
S
E
T
IEFF
D
DNAT
W
IAPNM
GTD
V
AL
ML
GIA
HT
L
M
T
QG
K
H
D
KV
FL
E
KY
TT
GY
PQ
-----
-
--
-
-
-
-
FEE
Y
LT
G
KS
-
D
N
T
P
K
SA
V
WAAEITG
V
P
EA
QI
V
KLA
-
E
LM
AA
NRTMLMA
GWG
I
QRQ
Q
Y
GEQ
K
H
WMLVT
L
AA
ML
G
QI
G
T
P
GG
GF
G
FSYHYSNGGNP
T
R
V
G
GV----
-
-
LP
E
M
S
AAIAG
H
A
S
-
-
-
--
E
A
A
D
D
G
G-
MTAI
PVARIV
D
ALENPGGKYQHN
GKE
QTYPN
IK
M
IW
-
W
AG
GGN
F
TH
H
Q
D
T
N
R
LIK
A
W
Q
-
-
-
K
P
EMIVV
S
E
C
YW
TA
A
AK
H
ADI
V
LP
ITT
SF
E
RN
DL
T
MTGD
YS
N
Q
-
H
I
V
PM
KQ
A
VA
P
Q
FE
ARNDFD
V
FADL
A
EL
L
K
P
GGKE
I
Y
TEG
K
D
E
MA
WLKF
F
Y
DAAQKG
AR
AQ
R
V
T
MP
M
F
N
A
F
W
QQ
NK
L
IEMR
R
S
E
K
NE
Q
YV
R
Y
G
D
FR
A
DP
V
K
N
A
L
G
TPSGKIEIYS
KT
L
E
K
FGYKDCPAH
P
TW
--
-
---
-
L
A
P
--
-
-
---
-
D
E
W
K
G
T
A
D
E
K
-
Q
LQL
L
TA
H
PA
H
R
L
HS
Q
LNYA
E
L
R
K
K
YA
I
A
D
R
EPIT
I
HTE
DA
A
R
F
GIANGD
L
VRV
W
N
K
RG
Q
IL
TG
A
V
VT
DG
I
KK
GV
V
C
V
HE
GAW
P
D
L
E
-
-
-
N
G
L
CKN
GS
A
N
V
LTA
D
I
PS
SQ
LA
NACA
G
N
S
A
LV
Y
IEKYTGNAPKLTAFDQPAVQA
fig|749544.3.peg.2393
Escherichia coli MS 175-1
MT
LT
RR
E
F
IK
H
S
G
I
AAG
AL
-
---
-
-
---
-
--
V
V
T
S
AAP
LP
AW
A
E
EK
-
--
G
G
K
I
LTA
G
RWG
A
MNVE
VKD
GK
I
-
---
V
S
STG
A
-
-
-
-
LAKTIPNS
L
QSTAADQVHTTA
RI
Q
HP
MVRKSY
L
D
N
P
LQPAKG
RGE
DTYVQV
SW
EQ
AL
KL
I
HEQ
H
D
RI
R
K
A
N
G
PS
A
I
F
--
-
-
AG
SY
G
WR
S
S
G
V
LHK
A
QT
L
LQ
R
Y
MN
LA
GG
Y
S
GH
S
G
D
YST
GAAQ
V
I
MP
H
VV
GS
VEVYEQQTSW
P
L
IL
ENS
QV
VV
LW
G
M
NP
LN
T
LKIAWSSTDEQ
GL
E
Y
F-
-
H
QLK
KS
GK
P
V
I
A
IDP
IR
S
E
T
IEFF
D
DNAT
W
IAPNM
GTD
V
AL
ML
GIA
HT
L
M
T
QG
K
H
D
KV
FL
E
KY
TT
GY
PQ
-----
-
--
-
-
-
-
FEE
Y
LT
G
KS
-
D
N
T
P
K
SA
V
WAAEITG
V
P
EA
QI
V
KLA
-
E
LM
AA
NRTMLMA
GWG
I
QRQ
Q
Y
GEQ
K
H
WMLVT
L
AA
ML
G
QI
G
T
P
GG
GF
G
FSYHYSNGGNP
T
R
V
G
GV----
-
-
LP
E
M
S
AAIAG
H
A
S
-
-
-
--
E
A
A
D
D
G
G-
MTAI
PVARIV
D
ALENPGGKYQHN
GKE
QTYPN
IK
M
IW
-
W
AG
GGN
F
TH
H
Q
D
T
N
R
LIK
A
W
Q
-
-
-
K
P
EMIVV
S
E
C
YW
TA
A
AK
H
ADI
V
LP
ITT
SF
E
RN
DL
T
MTGD
YS
N
Q
-
H
I
V
PM
KQ
A
VA
P
Q
FE
ARNDFD
V
FADL
A
EL
L
K
P
GGKE
I
Y
TEG
K
D
E
MA
WLKF
F
Y
DAAQKG
AR
AQ
R
V
T
MP
M
F
N
A
F
W
QQ
NK
L
IEMR
R
S
E
K
NE
Q
YV
R
Y
G
D
FR
A
DP
V
K
N
A
L
G
TPSGKIEIYS
KT
L
E
K
FGYKDCPAH
P
TW
--
-
---
-
L
A
P
--
-
-
---
-
D
E
W
K
G
T
A
D
E
K
-
Q
LQL
L
TA
H
PA
H
R
L
HS
Q
LNYA
E
L
R
K
K
YA
I
A
D
R
EPIT
I
HTE
DA
A
R
F
GIANGD
L
VRV
W
N
K
RG
Q
IL
TG
A
V
VT
DG
I
KK
GV
V
C
V
HE
GAW
P
D
L
E
-
-
-
N
G
L
CKN
GS
A
N
V
LTA
D
I
PS
SQ
LA
NACA
G
N
S
A
LV
Y
IEKYTGNAPKLTAFDQPAVQA
fig|656379.3.peg.2358
Escherichia coli FVEC1302
MT
LT
RR
E
F
IK
H
S
G
I
AAG
AL
-
---
-
-
---
-
--
V
V
T
S
AAP
LP
AW
A
E
EK
-
--
G
G
K
I
LTA
G
RWG
A
MNVE
VKD
GK
I
-
---
V
S
STG
A
-
-
-
-
LAKTIPNS
L
QSTAADQVHTTA
RI
Q
HP
MVRKSY
L
D
N
P
LQPAKG
RGE
DTYVQV
SW
EQ
AL
KL
I
HEQ
H
D
RI
R
K
A
N
G
PS
A
I
F
--
-
-
AG
SY
G
WR
S
S
G
V
LHK
A
QT
L
LQ
R
Y
MN
LA
GG
Y
S
GH
S
G
D
YST
GAAQ
V
I
MP
H
VV
GS
VEVYEQQTSW
P
L
IL
ENS
QV
VV
LW
G
M
NP
LN
T
LKIAWSSTDEQ
GL
E
Y
F-
-
H
QLK
KS
GK
P
V
I
A
IDP
IR
S
E
T
IEFF
G
DNAT
W
IAPNM
GTD
V
AL
ML
GIA
HT
L
M
T
QG
K
H
D
KV
FL
E
KY
TT
GY
PQ
-----
-
--
-
-
-
-
FEE
Y
LT
G
KS
-
D
N
T
P
K
SA
A
WAAEI
S
G
V
P
EA
QI
V
KLA
-
E
LM
AA
NRTMLMA
GWG
I
QRQ
Q
Y
GEQ
K
H
WMLVT
L
AA
ML
G
QI
G
T
P
GG
GF
G
FSYHYSNGGNP
T
R
V
G
GV----
-
-
LP
E
M
S
AAIAG
Q
A
S
-
-
-
--
E
A
A
D
D
G
G-
MTAI
PVARIV
D
ALENPGGKYQHN
GKE
QTYPN
IK
M
IW
-
W
AG
GGN
F
TH
H
Q
D
T
N
R
LIK
A
W
Q
-
-
-
K
P
EMIVV
S
E
C
YW
TA
A
AK
H
ADI
V
LP
ITT
SF
E
RN
DL
T
MTGD
YS
N
Q
-
H
I
V
PM
KQ
A
VA
A
Q
FE
ARNDFD
V
FADL
A
EL
L
K
P
GGKE
I
Y
TEG
K
D
E
MA
WLKF
F
Y
DAAQKG
AR
AQ
R
V
T
MP
M
F
N
A
F
W
QQ
NK
L
IEMR
R
S
E
K
NE
Q
YV
R
Y
G
D
FR
A
DP
V
K
N
A
L
G
TPSGKIEIYS
KT
L
E
K
FGYKDCPAH
P
TW
--
-
---
-
L
A
P
--
-
-
---
-
D
E
W
K
G
T
A
D
E
K
-
Q
LQL
L
TA
H
PA
H
R
L
HS
Q
LNYA
E
L
R
K
K
YAV
A
D
R
EPIT
I
HTE
DA
A
R
F
GIANGD
L
VRV
W
N
K
RG
Q
IL
TG
A
V
VT
DG
I
KK
GV
V
C
V
HE
GAW
P
D
L
E
-
-
-
N
G
L
CKN
GS
A
N
V
LTA
D
I
PS
SQ
LA
NACA
G
N
S
A
LV
Y
IEKYT
S
NAPKLTAFDQPAVQA
fig|656380.3.peg.3321
Escherichia coli FVEC1412
MT
LT
RR
E
F
IK
H
S
G
I
AAG
AL
-
---
-
-
---
-
--
V
V
T
S
AAP
LP
AW
A
E
EK
-
--
G
G
K
I
LTA
G
RWG
A
MNVE
VKD
GK
I
-
---
V
S
STG
A
-
-
-
-
LAKTIPNS
L
QSTAADQVHTTA
RI
Q
HP
MVRKSY
L
D
N
P
LQPAKG
RGE
DTYVQV
SW
EQ
AL
KL
I
HEQ
H
D
RI
R
K
A
N
G
PS
A
I
F
--
-
-
AG
SY
G
WR
S
S
G
V
LHK
A
QT
L
LQ
R
Y
MN
LA
GG
Y
S
GH
S
G
D
YST
GAAQ
V
I
MP
H
VV
GS
VEVYEQQTSW
P
L
IL
ENS
QV
VV
LW
G
M
NP
LN
T
LKIAWSSTDEQ
GL
E
Y
F-
-
H
QLK
KS
GK
P
V
I
A
IDP
IR
S
E
T
IEFF
G
DNAT
W
IAPNM
GTD
V
AL
ML
GIA
HT
L
M
T
QG
K
H
D
KV
FL
E
KY
TT
GY
PQ
-----
-
--
-
-
-
-
FEE
Y
LT
G
KS
-
D
N
T
P
K
SA
A
WAAEI
S
G
V
P
EA
QI
V
KLA
-
E
LM
AA
NRTMLMA
GWG
I
QRQ
Q
Y
GEQ
K
H
WMLVT
L
AA
ML
G
QI
G
T
P
GG
GF
G
FSYHYSNGGNP
T
R
V
G
GV----
-
-
LP
E
M
S
AAIAG
Q
A
S
-
-
-
--
E
A
A
D
D
G
G-
MTAI
PVARIV
D
ALENPGGKYQHN
GKE
QTYPN
IK
M
IW
-
W
AG
GGN
F
TH
H
Q
D
T
N
R
LIK
A
W
Q
-
-
-
K
P
EMIVV
S
E
C
YW
TA
A
AK
H
ADI
V
LP
ITT
SF
E
RN
DL
T
MTGD
YS
N
Q
-
H
I
V
PM
KQ
A
VA
A
Q
FE
ARNDFD
V
FADL
A
EL
L
K
P
GGKE
I
Y
TEG
K
D
E
MA
WLKF
F
Y
DAAQKG
AR
AQ
R
V
T
MP
M
F
N
A
F
W
QQ
NK
L
IEMR
R
S
E
K
NE
Q
YV
R
Y
G
D
FR
A
DP
V
K
N
A
L
G
TPSGKIEIYS
KT
L
E
K
FGYKDCPAH
P
TW
--
-
---
-
L
A
P
--
-
-
---
-
D
E
W
K
G
T
A
D
E
K
-
Q
LQL
L
TA
H
PA
H
R
L
HS
Q
LNYA
E
L
R
K
K
YAV
A
D
R
EPIT
I
HTE
DA
A
R
F
GIANGD
L
VRV
W
N
K
RG
Q
IL
TG
A
V
VT
DG
I
KK
GV
V
C
V
HE
GAW
P
D
L
E
-
-
-
N
G
L
CKN
GS
A
N
V
LTA
D
I
PS
SQ
LA
NACA
G
N
S
A
LV
Y
IEKYT
S
NAPKLTAFDQPAVQA
fig|749549.3.peg.3150
Escherichia coli MS 198-1
MT
LT
RR
E
F
IK
H
S
G
I
AAG
AL
-
---
-
-
---
-
--
V
V
T
S
AAP
LP
AW
A
E
EK
-
--
G
G
K
I
LTA
G
RWG
A
MNVE
VKD
GK
I
-
---
V
S
STG
A
-
-
-
-
LAKTIPNS
L
QSTAADQVHTTA
RI
Q
HP
MVRKSY
L
D
N
P
LQPAKG
RGE
DTYVQV
SW
EQ
AL
KL
I
HEQ
H
D
RI
R
K
A
N
G
PS
A
I
F
--
-
-
AG
SY
G
WR
S
S
G
V
LHK
A
QT
L
LQ
R
Y
MN
LA
GG
Y
S
GH
S
G
D
YST
GAAQ
V
I
MP
H
VV
GS
VEVYEQQTSW
P
L
IL
ENS
QV
VV
LW
G
M
NP
LN
T
LKIAWSSTDEQ
GL
E
Y
F-
-
H
QLK
KS
GK
P
V
I
A
IDP
IR
S
E
T
IEFF
G
DNAT
W
IAPNM
GTD
V
AL
ML
GIA
HT
L
M
T
QG
K
H
D
KV
FL
E
KY
TT
GY
PQ
-----
-
--
-
-
-
-
FEE
Y
LT
G
KS
-
D
N
T
P
K
SA
A
WAAEI
S
G
V
P
EA
QI
V
KLA
-
E
LM
AA
NRTMLMA
GWG
I
QRQ
Q
Y
GEQ
K
H
WMLVT
L
AA
ML
G
QI
G
T
P
GG
GF
G
FSYHYSNGGNP
T
R
V
G
GV----
-
-
LP
E
M
S
AAIAG
Q
A
S
-
-
-
--
E
A
A
D
D
G
G-
MTAI
PVARIV
D
ALENPGGKYQHN
GKE
QTYPN
IK
M
IW
-
W
AG
GGN
F
TH
H
Q
D
T
N
R
LIK
A
W
Q
-
-
-
K
P
EMIVV
S
E
C
YW
TA
A
AK
H
ADI
V
LP
ITT
SF
E
RN
DL
T
MTGD
YS
N
Q
-
H
I
V
PM
KQ
A
VA
A
Q
FE
ARNDFD
V
FADL
A
EL
L
K
P
GGKE
I
Y
TEG
K
D
E
MA
WLKF
F
Y
DAAQKG
AR
AQ
R
V
T
MP
M
F
N
A
F
W
QQ
NK
L
IEMR
R
S
E
K
NE
Q
YV
R
Y
G
D
FR
A
DP
V
K
N
A
L
G
TPSGKIEIYS
KT
L
E
K
FGYKDCPAH
P
TW
--
-
---
-
L
A
P
--
-
-
---
-
D
E
W
K
G
T
A
D
E
K
-
Q
LQL
L
TA
H
PA
H
R
L
HS
Q
LNYA
E
L
R
K
K
YAV
A
D
R
EPIT
I
HTE
DA
A
R
F
GIANGD
L
VRV
W
N
K
RG
Q
IL
TG
A
V
VT
DG
I
KK
GV
V
C
V
HE
GAW
P
D
L
E
-
-
-
N
G
L
CKN
GS
A
N
V
LTA
D
I
PS
SQ
LA
NACA
G
N
S
A
LV
Y
IEKYT
S
NAPKLTAFDQPAVQA
fig|585056.7.peg.2355
Escherichia coli UMN026
MT
LT
RR
E
F
IK
H
S
G
I
AAG
AL
-
---
-
-
---
-
--
V
V
T
S
AAP
LP
AW
A
E
EK
-
--
G
G
K
I
LTA
G
RWG
A
MNVE
VKD
GK
I
-
---
V
S
STG
A
-
-
-
-
LAKTIPNS
L
QSTAADQVHTTA
RI
Q
HP
MVRKSY
L
D
N
P
LQPAKG
RGE
DTYVQV
SW
EQ
AL
KL
I
HEQ
H
D
RI
R
K
A
N
G
PS
A
I
F
--
-
-
AG
SY
G
WR
S
S
G
V
LHK
A
QT
L
LQ
R
Y
MN
LA
GG
Y
S
GH
S
G
D
YST
GAAQ
V
I
MP
H
VV
GS
VEVYEQQTSW
P
L
IL
ENS
QV
VV
LW
G
M
NP
LN
T
LKIAWSSTDEQ
GL
E
Y
F-
-
H
QLK
KS
GK
P
V
I
A
IDP
IR
S
E
T
IEFF
G
DNAT
W
IAPNM
GTD
V
AL
ML
GIA
HT
L
M
T
QG
K
H
D
KV
FL
E
KY
TT
GY
PQ
-----
-
--
-
-
-
-
FEE
Y
LT
G
KS
-
D
N
T
P
K
SA
A
WAAEI
S
G
V
P
EA
QI
V
KLA
-
E
LM
AA
NRTMLMA
GWG
I
QRQ
Q
Y
GEQ
K
H
WMLVT
L
AA
ML
G
QI
G
T
P
GG
GF
G
FSYHYSNGGNP
T
R
V
G
GV----
-
-
LP
E
M
S
AAIAG
Q
A
S
-
-
-
--
E
A
A
D
D
G
G-
MTAI
PVARIV
D
ALENPGGKYQHN
GKE
QTYPN
IK
M
IW
-
W
AG
GGN
F
TH
H
Q
D
T
N
R
LIK
A
W
Q
-
-
-
K
P
EMIVV
S
E
C
YW
TA
A
AK
H
ADI
V
LP
ITT
SF
E
RN
DL
T
MTGD
YS
N
Q
-
H
I
V
PM
KQ
A
VA
A
Q
FE
ARNDFD
V
FADL
A
EL
L
K
P
GGKE
I
Y
TEG
K
D
E
MA
WLKF
F
Y
DAAQKG
AR
AQ
R
V
T
MP
M
F
N
A
F
W
QQ
NK
L
IEMR
R
S
E
K
NE
Q
YV
R
Y
G
D
FR
A
DP
V
K
N
A
L
G
TPSGKIEIYS
KT
L
E
K
FGYKDCPAH
P
TW
--
-
---
-
L
A
P
--
-
-
---
-
D
E
W
K
G
T
A
D
E
K
-
Q
LQL
L
TA
H
PA
H
R
L
HS
Q
LNYA
E
L
R
K
K
YAV
A
D
R
EPIT
I
HTE
DA
A
R
F
GIANGD
L
VRV
W
N
K
RG
Q
IL
TG
A
V
VT
DG
I
KK
GV
V
C
V
HE
GAW
P
D
L
E
-
-
-
N
G
L
CKN
GS
A
N
V
LTA
D
I
PS
SQ
LA
NACA
G
N
S
A
LV
Y
IEKYT
S
NAPKLTAFDQPAVQA
fig|585397.7.peg.2169
Escherichia coli ED1a
MT
LT
RR
E
F
IK
H
S
G
I
AAG
AL
-
---
-
-
---
-
--
V
V
T
S
AAP
LP
AW
A
E
EK
-
--
G
G
K
I
LTA
G
RWG
A
MNVE
VKD
GK
I
-
---
V
S
STG
A
-
-
-
-
LAKTIPNS
L
QSTAADQVHTTA
RI
Q
HP
MVRKSY
L
D
N
P
LQP
V
KG
RGE
DTYVQV
SW
EQ
AL
KL
I
HEQ
H
D
RI
R
K
A
N
G
PS
A
I
F
--
-
-
AG
SY
G
WR
S
S
G
V
LHK
A
QT
L
LQ
R
Y
MN
LA
GG
Y
S
GH
S
G
D
YST
GAAQ
V
I
MP
H
VV
GS
VEVYEQQTSW
P
L
IL
ENS
QV
VV
LW
G
M
NP
LN
T
LKIAWSSTDEQ
GL
E
Y
F-
-
H
QLK
KS
GK
P
V
I
A
IDP
IR
S
E
T
I
D
FF
G
DNAT
W
IAPNM
GTD
V
AL
ML
GIA
HT
L
M
V
QG
K
H
D
K
A
FL
E
KY
TT
GY
PQ
-----
-
--
-
-
-
-
FEE
Y
LT
G
KS
-
D
N
T
P
K
SA
A
WAAEITG
V
P
EA
QI
V
KLA
-
E
LM
AA
NRTMLMA
GWG
I
QRQ
Q
Y
GEQ
K
H
WMLVT
L
AA
ML
G
QI
G
T
P
GG
GF
G
FSYHYSNGGNP
T
R
V
G
GV----
-
-
LP
E
M
S
AAIAG
Q
A
S
-
-
-
--
E
A
A
D
D
G
G-
MTAI
PVARIV
D
ALENPGGKYQHN
GKE
QTYPN
IK
M
IW
-
W
AG
GGN
F
TH
H
Q
D
T
N
R
LIK
A
W
Q
-
-
-
K
P
EMIVV
S
E
C
YW
TA
A
AK
H
ADI
V
LP
ITT
SF
E
RN
DL
T
MTGD
YS
N
Q
-
H
I
V
PM
KQ
A
VA
P
Q
FE
ARNDFD
V
FADL
A
EL
L
K
P
GGKE
I
Y
TEG
K
D
E
MA
WLKF
F
Y
DAAQKG
AR
AQ
R
V
T
MP
M
F
N
A
F
W
QQ
NK
L
IEMR
R
S
E
K
NE
Q
YV
R
Y
G
D
FR
A
DP
V
K
N
A
L
G
TPSGKIEIYS
KT
L
E
K
FGYKDCPAH
P
TW
--
-
---
-
L
A
P
--
-
-
---
-
D
E
W
K
G
T
A
D
E
K
-
Q
LQL
L
TA
H
PA
H
R
L
HS
Q
LNYA
E
L
R
K
K
YA
A
A
D
R
EPIT
I
HTE
DA
A
R
F
GIANGD
L
VRV
W
N
K
RG
Q
IL
TG
A
V
VT
DG
I
KK
GV
V
C
V
HE
GAW
P
D
L
E
-
-
-
N
G
L
CKN
GS
A
N
V
LTA
D
I
PS
SQ
LA
NACA
G
N
S
A
LV
Y
IEKYTGNAPKLTAFDQPAVQA
fig|585397.9.peg.2165
Escherichia coli ED1a
MT
LT
RR
E
F
IK
H
S
G
I
AAG
AL
-
---
-
-
---
-
--
V
V
T
S
AAP
LP
AW
A
E
EK
-
--
G
G
K
I
LTA
G
RWG
A
MNVE
VKD
GK
I
-
---
V
S
STG
A
-
-
-
-
LAKTIPNS
L
QSTAADQVHTTA
RI
Q
HP
MVRKSY
L
D
N
P
LQP
V
KG
RGE
DTYVQV
SW
EQ
AL
KL
I
HEQ
H
D
RI
R
K
A
N
G
PS
A
I
F
--
-
-
AG
SY
G
WR
S
S
G
V
LHK
A
QT
L
LQ
R
Y
MN
LA
GG
Y
S
GH
S
G
D
YST
GAAQ
V
I
MP
H
VV
GS
VEVYEQQTSW
P
L
IL
ENS
QV
VV
LW
G
M
NP
LN
T
LKIAWSSTDEQ
GL
E
Y
F-
-
H
QLK
KS
GK
P
V
I
A
IDP
IR
S
E
T
I
D
FF
G
DNAT
W
IAPNM
GTD
V
AL
ML
GIA
HT
L
M
V
QG
K
H
D
K
A
FL
E
KY
TT
GY
PQ
-----
-
--
-
-
-
-
FEE
Y
LT
G
KS
-
D
N
T
P
K
SA
A
WAAEITG
V
P
EA
QI
V
KLA
-
E
LM
AA
NRTMLMA
GWG
I
QRQ
Q
Y
GEQ
K
H
WMLVT
L
AA
ML
G
QI
G
T
P
GG
GF
G
FSYHYSNGGNP
T
R
V
G
GV----
-
-
LP
E
M
S
AAIAG
Q
A
S
-
-
-
--
E
A
A
D
D
G
G-
MTAI
PVARIV
D
ALENPGGKYQHN
GKE
QTYPN
IK
M
IW
-
W
AG
GGN
F
TH
H
Q
D
T
N
R
LIK
A
W
Q
-
-
-
K
P
EMIVV
S
E
C
YW
TA
A
AK
H
ADI
V
LP
ITT
SF
E
RN
DL
T
MTGD
YS
N
Q
-
H
I
V
PM
KQ
A
VA
P
Q
FE
ARNDFD
V
FADL
A
EL
L
K
P
GGKE
I
Y
TEG
K
D
E
MA
WLKF
F
Y
DAAQKG
AR
AQ
R
V
T
MP
M
F
N
A
F
W
QQ
NK
L
IEMR
R
S
E
K
NE
Q
YV
R
Y
G
D
FR
A
DP
V
K
N
A
L
G
TPSGKIEIYS
KT
L
E
K
FGYKDCPAH
P
TW
--
-
---
-
L
A
P
--
-
-
---
-
D
E
W
K
G
T
A
D
E
K
-
Q
LQL
L
TA
H
PA
H
R
L
HS
Q
LNYA
E
L
R
K
K
YA
A
A
D
R
EPIT
I
HTE
DA
A
R
F
GIANGD
L
VRV
W
N
K
RG
Q
IL
TG
A
V
VT
DG
I
KK
GV
V
C
V
HE
GAW
P
D
L
E
-
-
-
N
G
L
CKN
GS
A
N
V
LTA
D
I
PS
SQ
LA
NACA
G
N
S
A
LV
Y
IEKYTGNAPKLTAFDQPAVQA
fig|656417.3.peg.2475
Escherichia coli M605
MT
LT
RR
E
F
IK
H
S
G
I
AAG
T
L
-
---
-
-
---
-
--
V
V
T
S
AAP
LP
AW
A
E
EK
-
--
G
G
K
I
LTA
G
RWG
A
MNVE
VKD
GK
I
-
---
V
S
STG
A
-
-
-
-
LAKTIPNS
L
QSTAADQVHTTA
RI
Q
HP
MVRKSY
L
D
N
P
LQPAKG
RGE
DTYVQV
SW
EQ
AL
KL
I
HEQ
H
D
RI
R
K
A
N
G
PS
A
I
F
--
-
-
AG
SY
G
WR
S
S
G
V
LHK
A
QT
L
LQ
R
Y
MN
LA
GG
Y
S
GH
S
G
D
YST
GAAQ
V
I
MP
H
VV
GS
VEVYEQQTSW
P
L
IL
ENS
QV
VV
LW
G
M
NP
LN
T
LKIAWSSTDEQ
GL
E
Y
F-
-
H
QLK
KS
GK
P
V
I
A
IDP
IR
S
E
T
IEFF
G
DNAT
W
IAPNM
GTD
V
AL
ML
GIA
HT
L
M
T
QG
K
H
D
KV
FL
E
KY
TT
GY
PQ
-----
-
--
-
-
-
-
FEE
Y
LT
G
K
N
-
D
N
T
P
K
SA
A
WAAEITG
V
P
EA
QI
V
KLA
-
E
LM
AA
NRTMLMA
GWG
I
QRQ
Q
Y
GEQ
K
H
WMLVT
L
AA
ML
G
QI
G
T
P
GG
GF
G
FSYHYSNGGNP
T
R
V
G
GV----
-
-
LP
E
M
S
AAIAG
Q
A
S
-
-
-
--
E
A
A
D
D
G
G-
MTAI
PVARIV
D
ALENPGGKYQHN
GKE
QTYPN
IK
M
IW
-
W
AG
GGN
F
TH
H
Q
D
T
N
R
LIK
A
W
Q
-
-
-
K
P
EMIVV
S
E
C
YW
TA
A
AK
H
ADI
V
LP
ITT
SF
E
RN
DL
T
MTGD
YS
N
Q
-
H
I
V
PM
KQ
A
VA
P
Q
FE
ARNDFD
V
FADL
A
EL
L
K
P
GGKE
I
Y
TEG
K
D
E
MA
WLKF
F
Y
DAAQKG
AR
AQ
R
V
T
MP
M
F
N
A
F
W
QQ
NK
L
IEMR
R
S
E
K
NE
Q
Y
I
R
Y
G
D
FR
A
DP
V
K
N
A
L
G
TPSGKIEIYS
RT
L
E
K
FGYKDCPAH
P
TW
--
-
---
-
L
A
P
--
-
-
---
-
D
E
W
K
G
T
A
D
E
K
-
Q
LQL
L
TA
H
PA
H
R
L
HS
Q
LNYA
E
L
R
K
K
YAV
A
D
R
EPIT
I
HTE
DA
A
R
F
GIANGD
L
VRV
W
N
K
RG
Q
IL
TG
A
V
VT
DG
I
KK
GV
V
C
V
HE
GAW
P
D
L
E
-
-
-
N
G
L
CKN
GS
A
N
V
LTA
D
I
PS
SQ
LA
NACA
G
N
S
A
LV
Y
IEKYTGNA
L
KLTAFDQPAVQA
fig|431946.3.peg.1798
Escherichia coli SE15
MT
LT
RR
E
F
IK
H
S
G
I
AAG
AL
-
---
-
-
---
-
--
V
V
T
S
AAP
LP
AW
A
E
EK
-
--
G
G
K
I
LTA
G
RWG
A
MNVE
VKD
GK
I
-
---
V
S
STG
A
-
-
-
-
LAKTIPNS
L
QSTAADQVHTTA
RI
Q
HP
MVRKSY
L
D
N
P
LQPAKG
RGE
DTYVQV
SW
EQ
AL
KL
I
HEQ
H
D
H
I
R
K
A
N
G
PS
A
I
F
--
-
-
AG
SY
G
WR
S
S
G
V
LHK
A
QT
L
LQ
R
Y
MN
LA
GG
Y
S
GH
S
G
D
YST
GAAQ
V
I
MP
H
VV
GS
VEVYEQQTSW
P
L
IL
ENS
QV
VV
LW
G
M
NP
LN
T
LKIAWSSTDEQ
GL
E
Y
F-
-
H
QLK
KS
GK
P
V
I
A
IDP
IR
S
E
T
IEFF
G
DNAT
W
IAPNM
GTD
V
AL
ML
GIA
HT
L
M
T
QG
K
H
D
KV
FL
E
KY
TT
GY
PQ
-----
-
--
-
-
-
-
FEE
Y
LT
G
K
N
-
D
N
T
P
K
SA
A
WAAEITG
V
P
EA
QI
V
KLA
-
E
LM
AA
NRTMLMA
GWG
I
QRQ
Q
Y
GEQ
K
H
WMLVT
L
AA
ML
G
QI
G
T
P
GG
GF
G
FSYHYSNGGNP
T
R
V
G
GV----
-
-
LP
E
M
S
AAIAG
Q
A
S
-
-
-
--
E
A
A
D
D
G
G-
MTAI
PVARIV
D
ALENPGGKYQHN
GKE
QTYPN
IK
M
IW
-
W
AG
GGN
F
TH
H
Q
D
T
N
R
LIK
A
W
Q
-
-
-
K
P
EMIVV
S
E
C
YW
TA
A
AK
H
ADI
V
LP
ITT
SF
E
RN
DL
T
MTGD
YS
N
Q
-
H
I
V
PM
KQ
A
VA
P
Q
FE
ARNDFD
V
FADL
A
EL
L
K
P
GGKE
I
Y
TEG
K
D
E
MA
WLKF
F
Y
DAAQKG
AR
AQ
R
V
T
MP
M
F
N
A
F
W
QQ
NK
L
IEMR
R
S
E
K
NE
Q
Y
I
R
Y
G
D
FR
A
DP
V
K
N
A
L
G
TPSGKIEIYS
RT
L
E
K
FGYKDCPAH
P
TW
--
-
---
-
L
A
P
--
-
-
---
-
D
E
W
K
G
T
A
D
E
K
-
Q
LQL
L
TA
H
PA
H
R
L
HS
Q
LNYA
E
L
R
K
K
YAV
A
D
R
EPIT
I
HTE
DA
A
R
F
GIANGD
L
VRV
W
N
K
RG
Q
IL
TG
A
V
VT
DG
I
KK
GV
V
C
V
HE
GAW
P
D
L
E
-
-
-
N
G
L
CKN
GS
A
N
V
LTA
D
I
PS
SQ
LA
NACA
G
N
S
A
LV
Y
IEKYTGNA
L
KLTAFDQPA
I
QA
fig|749545.3.peg.2995
Escherichia coli MS 182-1
MT
LT
RR
E
F
IK
H
S
G
I
AAG
AL
-
---
-
-
---
-
--
V
V
T
S
AAP
LP
AW
A
E
EK
-
--
G
G
K
I
LTA
G
RWG
A
MNVE
VKD
GK
I
-
---
V
S
STG
A
-
-
-
-
LAKTIPNS
L
QSTAADQVHTTA
RI
Q
HP
MVRKSY
L
D
N
P
LQPAKG
RG
K
DTYVQV
SW
EQ
AL
KL
I
HEQ
H
E
RI
R
K
A
N
G
PS
A
I
F
--
-
-
AG
SY
G
WR
S
S
G
V
LHK
A
QT
L
LQ
R
Y
MN
LA
GG
Y
S
GH
S
G
D
YST
GAAQ
V
I
MP
H
VV
GS
VEVYEQQTSW
P
L
IL
ENS
QV
VV
LW
G
M
NP
LN
T
LKIAWSSTDEQ
GL
E
Y
F-
-
H
QLK
KS
GK
P
V
I
A
IDP
IR
S
E
T
IEFF
G
DNAT
W
IAPNM
GTD
V
AL
ML
GIA
HT
L
M
T
QG
K
H
D
KV
FL
E
KY
TT
GY
PQ
-----
-
--
-
-
-
-
FEE
Y
LT
G
KS
-
D
N
T
P
K
SA
A
WAAEITG
V
P
EA
QI
V
KLA
-
E
LM
AA
NRTMLMA
GWG
I
QRQ
Q
Y
GEQ
K
H
WMLVT
L
AA
ML
G
QI
G
T
P
GG
GF
G
FSYHYSNGGNP
T
R
V
G
GV----
-
-
LP
E
M
S
AAIAG
Q
A
S
-
-
-
--
E
A
A
D
D
G
G-
M
R
AI
PVARIV
D
ALENPGGKYQHN
GKE
QTYPN
IK
M
IW
-
W
AG
GGN
F
TH
H
Q
D
T
N
R
LIK
A
W
Q
-
-
-
K
P
EMIVV
S
E
C
YW
TA
A
AK
H
ADI
V
LP
ITT
SF
E
RN
DL
T
MTGD
YS
N
Q
-
H
I
V
PM
KQ
A
VA
P
Q
FE
ARNDFD
V
FADL
A
EL
L
K
P
GGKE
I
Y
TEG
K
D
E
MA
WLKF
F
Y
DAAQKG
AR
AQ
R
V
T
MP
M
F
N
A
F
W
QQ
NK
L
IEMR
R
S
E
K
NE
Q
YV
R
Y
G
D
FR
A
DP
V
K
N
A
L
G
TPSGKIEIYS
KT
L
E
K
FGYKDCPAH
P
TW
--
-
---
-
L
V
P
--
-
-
---
-
D
E
W
K
G
T
A
D
E
K
-
Q
LQL
L
TA
H
PA
H
R
L
HS
Q
LNYA
G
L
R
K
K
YAV
A
D
R
EPIT
I
HTE
DA
A
R
F
GIANGD
L
VRV
W
N
K
RG
Q
IL
TG
A
V
VT
DG
I
KK
GV
V
C
V
HE
GAW
P
D
L
E
-
-
-
N
G
L
CKN
GS
A
N
V
LTA
D
I
PS
SQ
LA
NACA
G
N
S
A
LV
Y
IEKYTGNAPKLTAFD
K
PAVQA
fig|749532.3.peg.2439
Escherichia coli MS 78-1
MT
LT
RR
E
F
IK
H
S
G
I
AAG
AL
-
---
-
-
---
-
--
V
V
T
S
AAP
LP
AW
A
E
EK
-
--
G
G
K
I
LTA
G
RWG
A
MNVE
VKD
GK
I
-
---
V
S
STG
A
-
-
-
-
LAKTIPNS
L
QSTAADQVHTTA
RI
Q
HP
MVRKSY
L
D
N
P
LQPAKG
RG
K
DTYVQV
SW
EQ
AL
KL
I
HEQ
H
E
RI
R
K
A
N
G
PS
A
I
F
--
-
-
AG
SY
G
WR
S
S
G
V
LHK
A
QT
L
LQ
R
Y
MN
LA
GG
Y
S
GH
S
G
D
YST
GAAQ
V
I
MP
H
VV
GS
VEVYEQQTSW
P
L
IL
ENS
QV
VV
LW
G
M
NP
LN
T
LKIAWSSTDEQ
GL
E
Y
F-
-
H
QLK
KS
GK
P
V
I
A
IDP
IR
S
E
T
IEFF
G
DNAT
W
IAPNM
GTD
V
AL
ML
GIA
HT
L
M
T
QG
K
H
D
KV
FL
E
KY
TT
GY
PQ
-----
-
--
-
-
-
-
FEE
Y
LT
G
KS
-
D
N
T
P
K
SA
A
WAAEITG
V
P
EA
QI
V
KLA
-
E
LM
AA
NRTMLMA
GWG
I
QRQ
Q
Y
GEQ
K
H
WMLVT
L
AA
ML
G
QI
G
T
P
GG
GF
G
FSYHYSNGGNP
T
R
V
G
GV----
-
-
LP
E
M
S
AAIAG
Q
A
S
-
-
-
--
E
A
A
D
D
G
G-
M
R
AI
PVARIV
D
ALENPGGKYQHN
GKE
QTYPN
IK
M
IW
-
W
AG
GGN
F
TH
H
Q
D
T
N
R
LIK
A
W
Q
-
-
-
K
P
EMIVV
S
E
C
YW
TA
A
AK
H
ADI
V
LP
ITT
SF
E
RN
DL
T
MTGD
YS
N
Q
-
H
I
V
PM
KQ
A
VA
P
Q
FE
ARNDFD
V
FADL
A
EL
L
K
P
GGKE
I
Y
TEG
K
D
E
MA
WLKF
F
Y
DAAQKG
AR
AQ
R
V
T
MP
M
F
N
A
F
W
QQ
NK
L
IEMR
R
S
E
K
NE
Q
YV
R
Y
G
D
FR
A
DP
V
K
N
A
L
G
TPSGKIEIYS
KT
L
E
K
FGYKDCPAH
P
TW
--
-
---
-
L
V
P
--
-
-
---
-
D
E
W
K
G
T
A
D
E
K
-
Q
LQL
L
TA
H
PA
H
R
L
HS
Q
LNYA
G
L
R
K
K
YAV
A
D
R
EPIT
I
HTE
DA
A
R
F
GIANGD
L
VRV
W
N
K
RG
Q
IL
TG
A
V
VT
DG
I
KK
GV
V
C
V
HE
GAW
P
D
L
E
-
-
-
N
G
L
CKN
GS
A
N
V
LTA
D
I
PS
SQ
LA
NACA
G
N
S
A
LV
Y
IEKYTGNAPKLTAFD
K
PAVQA
fig|595496.3.peg.1842
Escherichia coli BW2952
MT
LT
RR
E
F
IK
H
S
G
I
AAG
AL
-
---
-
-
---
-
--
V
V
T
S
AAP
LP
AW
A
E
EK
-
--
G
G
K
I
LTA
G
RWG
A
MNVE
VKD
GK
I
-
---
V
S
STG
A
-
-
-
-
LAKTIPNS
L
QSTAADQVHTTA
RI
Q
HP
MVRKSY
L
D
N
P
LQPAKG
RGE
DTYVQV
SW
EQ
AL
KL
I
HEQ
H
D
RI
R
K
A
N
G
PS
A
I
F
--
-
-
AG
SY
G
WR
S
S
G
V
LHK
A
QT
L
LQ
R
Y
MN
LA
GG
Y
S
GH
S
G
D
YST
GAAQ
V
I
MP
H
VV
GS
VEVYEQQTSW
P
L
IL
ENS
QV
VV
LW
G
M
NP
LN
T
LKIAWSSTDEQ
GL
E
Y
F-
-
H
QLK
KS
GK
P
V
I
A
IDP
IR
S
E
T
IEFF
D
DNAT
W
IAPNM
GTD
V
AL
ML
GIA
HT
L
M
T
QG
K
H
D
KV
FL
E
KY
TT
GY
PQ
-----
-
--
-
-
-
-
FEE
Y
LT
G
KS
-
D
N
T
P
K
SA
V
WAAEITG
V
P
EA
QI
V
KLA
-
E
LM
AA
NRTMLMA
GWG
I
QRQ
Q
Y
GEQ
K
H
WMLVT
L
AA
ML
G
QI
G
T
P
GG
GF
G
FSYHYSNGGNP
T
R
V
G
GV----
-
-
LP
E
M
S
AAIAG
H
A
S
-
-
-
--
E
A
A
D
D
G
G-
MTAI
PVARIV
D
ALENPGGKYQHN
GKE
QTYPN
IK
M
IW
-
W
AG
GGN
F
TH
H
Q
D
T
N
R
LIK
A
W
Q
-
-
-
K
P
EMIVV
S
E
C
YW
TA
A
AK
H
ADI
V
LP
ITT
SF
E
RN
DL
T
MTGD
YS
N
Q
-
H
I
V
PM
KQ
A
VA
P
Q
FE
ARNDFD
V
FADL
A
EL
L
K
P
GGKE
I
Y
TEG
K
D
E
MA
WLKF
F
Y
DAAQKG
AR
AQ
R
V
T
MP
M
F
N
A
F
W
QQ
NK
L
IEMR
H
S
E
K
NE
Q
YV
R
Y
G
D
FR
A
DP
V
K
N
A
L
G
TPSGKIEIYS
KT
L
E
K
FGYKDCPAH
P
TW
--
-
---
-
L
A
P
--
-
-
---
-
D
E
W
K
G
T
A
D
E
K
-
Q
LQL
L
TA
H
PA
H
R
L
HS
Q
LNYA
E
L
R
K
K
YA
I
A
D
R
EPIT
I
HTE
DA
A
R
F
GIANGD
L
VRV
W
N
K
RG
Q
IL
TG
A
V
VT
DG
I
KK
GV
V
C
V
HE
GAW
P
D
L
E
-
-
-
N
G
L
CKN
GS
A
N
V
LTA
D
I
PS
SQ
LA
NACA
G
N
S
A
LV
Y
IEKYTGNAPKLTAFDQPAVQA
fig|536056.3.peg.1870
Escherichia coli DH1
MT
LT
RR
E
F
IK
H
S
G
I
AAG
AL
-
---
-
-
---
-
--
V
V
T
S
AAP
LP
AW
A
E
EK
-
--
G
G
K
I
LTA
G
RWG
A
MNVE
VKD
GK
I
-
---
V
S
STG
A
-
-
-
-
LAKTIPNS
L
QSTAADQVHTTA
RI
Q
HP
MVRKSY
L
D
N
P
LQPAKG
RGE
DTYVQV
SW
EQ
AL
KL
I
HEQ
H
D
RI
R
K
A
N
G
PS
A
I
F
--
-
-
AG
SY
G
WR
S
S
G
V
LHK
A
QT
L
LQ
R
Y
MN
LA
GG
Y
S
GH
S
G
D
YST
GAAQ
V
I
MP
H
VV
GS
VEVYEQQTSW
P
L
IL
ENS
QV
VV
LW
G
M
NP
LN
T
LKIAWSSTDEQ
GL
E
Y
F-
-
H
QLK
KS
GK
P
V
I
A
IDP
IR
S
E
T
IEFF
D
DNAT
W
IAPNM
GTD
V
AL
ML
GIA
HT
L
M
T
QG
K
H
D
KV
FL
E
KY
TT
GY
PQ
-----
-
--
-
-
-
-
FEE
Y
LT
G
KS
-
D
N
T
P
K
SA
V
WAAEITG
V
P
EA
QI
V
KLA
-
E
LM
AA
NRTMLMA
GWG
I
QRQ
Q
Y
GEQ
K
H
WMLVT
L
AA
ML
G
QI
G
T
P
GG
GF
G
FSYHYSNGGNP
T
R
V
G
GV----
-
-
LP
E
M
S
AAIAG
H
A
S
-
-
-
--
E
A
A
D
D
G
G-
MTAI
PVARIV
D
ALENPGGKYQHN
GKE
QTYPN
IK
M
IW
-
W
AG
GGN
F
TH
H
Q
D
T
N
R
LIK
A
W
Q
-
-
-
K
P
EMIVV
S
E
C
YW
TA
A
AK
H
ADI
V
LP
ITT
SF
E
RN
DL
T
MTGD
YS
N
Q
-
H
I
V
PM
KQ
A
VA
P
Q
FE
ARNDFD
V
FADL
A
EL
L
K
P
GGKE
I
Y
TEG
K
D
E
MA
WLKF
F
Y
DAAQKG
AR
AQ
R
V
T
MP
M
F
N
A
F
W
QQ
NK
L
IEMR
H
S
E
K
NE
Q
YV
R
Y
G
D
FR
A
DP
V
K
N
A
L
G
TPSGKIEIYS
KT
L
E
K
FGYKDCPAH
P
TW
--
-
---
-
L
A
P
--
-
-
---
-
D
E
W
K
G
T
A
D
E
K
-
Q
LQL
L
TA
H
PA
H
R
L
HS
Q
LNYA
E
L
R
K
K
YA
I
A
D
R
EPIT
I
HTE
DA
A
R
F
GIANGD
L
VRV
W
N
K
RG
Q
IL
TG
A
V
VT
DG
I
KK
GV
V
C
V
HE
GAW
P
D
L
E
-
-
-
N
G
L
CKN
GS
A
N
V
LTA
D
I
PS
SQ
LA
NACA
G
N
S
A
LV
Y
IEKYTGNAPKLTAFDQPAVQA
fig|83333.1.peg.1856
Escherichia coli K12
MT
LT
RR
E
F
IK
H
S
G
I
AAG
AL
-
---
-
-
---
-
--
V
V
T
S
AAP
LP
AW
A
E
EK
-
--
G
G
K
I
LTA
G
RWG
A
MNVE
VKD
GK
I
-
---
V
S
STG
A
-
-
-
-
LAKTIPNS
L
QSTAADQVHTTA
RI
Q
HP
MVRKSY
L
D
N
P
LQPAKG
RGE
DTYVQV
SW
EQ
AL
KL
I
HEQ
H
D
RI
R
K
A
N
G
PS
A
I
F
--
-
-
AG
SY
G
WR
S
S
G
V
LHK
A
QT
L
LQ
R
Y
MN
LA
GG
Y
S
GH
S
G
D
YST
GAAQ
V
I
MP
H
VV
GS
VEVYEQQTSW
P
L
IL
ENS
QV
VV
LW
G
M
NP
LN
T
LKIAWSSTDEQ
GL
E
Y
F-
-
H
QLK
KS
GK
P
V
I
A
IDP
IR
S
E
T
IEFF
D
DNAT
W
IAPNM
GTD
V
AL
ML
GIA
HT
L
M
T
QG
K
H
D
KV
FL
E
KY
TT
GY
PQ
-----
-
--
-
-
-
-
FEE
Y
LT
G
KS
-
D
N
T
P
K
SA
V
WAAEITG
V
P
EA
QI
V
KLA
-
E
LM
AA
NRTMLMA
GWG
I
QRQ
Q
Y
GEQ
K
H
WMLVT
L
AA
ML
G
QI
G
T
P
GG
GF
G
FSYHYSNGGNP
T
R
V
G
GV----
-
-
LP
E
M
S
AAIAG
H
A
S
-
-
-
--
E
A
A
D
D
G
G-
MTAI
PVARIV
D
ALENPGGKYQHN
GKE
QTYPN
IK
M
IW
-
W
AG
GGN
F
TH
H
Q
D
T
N
R
LIK
A
W
Q
-
-
-
K
P
EMIVV
S
E
C
YW
TA
A
AK
H
ADI
V
LP
ITT
SF
E
RN
DL
T
MTGD
YS
N
Q
-
H
I
V
PM
KQ
A
VA
P
Q
FE
ARNDFD
V
FADL
A
EL
L
K
P
GGKE
I
Y
TEG
K
D
E
MA
WLKF
F
Y
DAAQKG
AR
AQ
R
V
T
MP
M
F
N
A
F
W
QQ
NK
L
IEMR
H
S
E
K
NE
Q
YV
R
Y
G
D
FR
A
DP
V
K
N
A
L
G
TPSGKIEIYS
KT
L
E
K
FGYKDCPAH
P
TW
--
-
---
-
L
A
P
--
-
-
---
-
D
E
W
K
G
T
A
D
E
K
-
Q
LQL
L
TA
H
PA
H
R
L
HS
Q
LNYA
E
L
R
K
K
YA
I
A
D
R
EPIT
I
HTE
DA
A
R
F
GIANGD
L
VRV
W
N
K
RG
Q
IL
TG
A
V
VT
DG
I
KK
GV
V
C
V
HE
GAW
P
D
L
E
-
-
-
N
G
L
CKN
GS
A
N
V
LTA
D
I
PS
SQ
LA
NACA
G
N
S
A
LV
Y
IEKYTGNAPKLTAFDQPAVQA
fig|316407.3.peg.1828
Escherichia coli W3110
MT
LT
RR
E
F
IK
H
S
G
I
AAG
AL
-
---
-
-
---
-
--
V
V
T
S
AAP
LP
AW
A
E
EK
-
--
G
G
K
I
LTA
G
RWG
A
MNVE
VKD
GK
I
-
---
V
S
STG
A
-
-
-
-
LAKTIPNS
L
QSTAADQVHTTA
RI
Q
HP
MVRKSY
L
D
N
P
LQPAKG
RGE
DTYVQV
SW
EQ
AL
KL
I
HEQ
H
D
RI
R
K
A
N
G
PS
A
I
F
--
-
-
AG
SY
G
WR
S
S
G
V
LHK
A
QT
L
LQ
R
Y
MN
LA
GG
Y
S
GH
S
G
D
YST
GAAQ
V
I
MP
H
VV
GS
VEVYEQQTSW
P
L
IL
ENS
QV
VV
LW
G
M
NP
LN
T
LKIAWSSTDEQ
GL
E
Y
F-
-
H
QLK
KS
GK
P
V
I
A
IDP
IR
S
E
T
IEFF
D
DNAT
W
IAPNM
GTD
V
AL
ML
GIA
HT
L
M
T
QG
K
H
D
KV
FL
E
KY
TT
GY
PQ
-----
-
--
-
-
-
-
FEE
Y
LT
G
KS
-
D
N
T
P
K
SA
V
WAAEITG
V
P
EA
QI
V
KLA
-
E
LM
AA
NRTMLMA
GWG
I
QRQ
Q
Y
GEQ
K
H
WMLVT
L
AA
ML
G
QI
G
T
P
GG
GF
G
FSYHYSNGGNP
T
R
V
G
GV----
-
-
LP
E
M
S
AAIAG
H
A
S
-
-
-
--
E
A
A
D
D
G
G-
MTAI
PVARIV
D
ALENPGGKYQHN
GKE
QTYPN
IK
M
IW
-
W
AG
GGN
F
TH
H
Q
D
T
N
R
LIK
A
W
Q
-
-
-
K
P
EMIVV
S
E
C
YW
TA
A
AK
H
ADI
V
LP
ITT
SF
E
RN
DL
T
MTGD
YS
N
Q
-
H
I
V
PM
KQ
A
VA
P
Q
FE
ARNDFD
V
FADL
A
EL
L
K
P
GGKE
I
Y
TEG
K
D
E
MA
WLKF
F
Y
DAAQKG
AR
AQ
R
V
T
MP
M
F
N
A
F
W
QQ
NK
L
IEMR
H
S
E
K
NE
Q
YV
R
Y
G
D
FR
A
DP
V
K
N
A
L
G
TPSGKIEIYS
KT
L
E
K
FGYKDCPAH
P
TW
--
-
---
-
L
A
P
--
-
-
---
-
D
E
W
K
G
T
A
D
E
K
-
Q
LQL
L
TA
H
PA
H
R
L
HS
Q
LNYA
E
L
R
K
K
YA
I
A
D
R
EPIT
I
HTE
DA
A
R
F
GIANGD
L
VRV
W
N
K
RG
Q
IL
TG
A
V
VT
DG
I
KK
GV
V
C
V
HE
GAW
P
D
L
E
-
-
-
N
G
L
CKN
GS
A
N
V
LTA
D
I
PS
SQ
LA
NACA
G
N
S
A
LV
Y
IEKYTGNAPKLTAFDQPAVQA
fig|316385.7.peg.2040
Escherichia coli str. K-12 substr. DH10B
MT
LT
RR
E
F
IK
H
S
G
I
AAG
AL
-
---
-
-
---
-
--
V
V
T
S
AAP
LP
AW
A
E
EK
-
--
G
G
K
I
LTA
G
RWG
A
MNVE
VKD
GK
I
-
---
V
S
STG
A
-
-
-
-
LAKTIPNS
L
QSTAADQVHTTA
RI
Q
HP
MVRKSY
L
D
N
P
LQPAKG
RGE
DTYVQV
SW
EQ
AL
KL
I
HEQ
H
D
RI
R
K
A
N
G
PS
A
I
F
--
-
-
AG
SY
G
WR
S
S
G
V
LHK
A
QT
L
LQ
R
Y
MN
LA
GG
Y
S
GH
S
G
D
YST
GAAQ
V
I
MP
H
VV
GS
VEVYEQQTSW
P
L
IL
ENS
QV
VV
LW
G
M
NP
LN
T
LKIAWSSTDEQ
GL
E
Y
F-
-
H
QLK
KS
GK
P
V
I
A
IDP
IR
S
E
T
IEFF
D
DNAT
W
IAPNM
GTD
V
AL
ML
GIA
HT
L
M
T
QG
K
H
D
KV
FL
E
KY
TT
GY
PQ
-----
-
--
-
-
-
-
FEE
Y
LT
G
KS
-
D
N
T
P
K
SA
V
WAAEITG
V
P
EA
QI
V
KLA
-
E
LM
AA
NRTMLMA
GWG
I
QRQ
Q
Y
GEQ
K
H
WMLVT
L
AA
ML
G
QI
G
T
P
GG
GF
G
FSYHYSNGGNP
T
R
V
G
GV----
-
-
LP
E
M
S
AAIAG
H
A
S
-
-
-
--
E
A
A
D
D
G
G-
MTAI
PVARIV
D
ALENPGGKYQHN
GKE
QTYPN
IK
M
IW
-
W
AG
GGN
F
TH
H
Q
D
T
N
R
LIK
A
W
Q
-
-
-
K
P
EMIVV
S
E
C
YW
TA
A
AK
H
ADI
V
LP
ITT
SF
E
RN
DL
T
MTGD
YS
N
Q
-
H
I
V
PM
KQ
A
VA
P
Q
FE
ARNDFD
V
FADL
A
EL
L
K
P
GGKE
I
Y
TEG
K
D
E
MA
WLKF
F
Y
DAAQKG
AR
AQ
R
V
T
MP
M
F
N
A
F
W
QQ
NK
L
IEMR
H
S
E
K
NE
Q
YV
R
Y
G
D
FR
A
DP
V
K
N
A
L
G
TPSGKIEIYS
KT
L
E
K
FGYKDCPAH
P
TW
--
-
---
-
L
A
P
--
-
-
---
-
D
E
W
K
G
T
A
D
E
K
-
Q
LQL
L
TA
H
PA
H
R
L
HS
Q
LNYA
E
L
R
K
K
YA
I
A
D
R
EPIT
I
HTE
DA
A
R
F
GIANGD
L
VRV
W
N
K
RG
Q
IL
TG
A
V
VT
DG
I
KK
GV
V
C
V
HE
GAW
P
D
L
E
-
-
-
N
G
L
CKN
GS
A
N
V
LTA
D
I
PS
SQ
LA
NACA
G
N
S
A
LV
Y
IEKYTGNAPKLTAFDQPAVQA
fig|511145.12.peg.1952
Escherichia coli str. K-12 substr. MG1655
MT
LT
RR
E
F
IK
H
S
G
I
AAG
AL
-
---
-
-
---
-
--
V
V
T
S
AAP
LP
AW
A
E
EK
-
--
G
G
K
I
LTA
G
RWG
A
MNVE
VKD
GK
I
-
---
V
S
STG
A
-
-
-
-
LAKTIPNS
L
QSTAADQVHTTA
RI
Q
HP
MVRKSY
L
D
N
P
LQPAKG
RGE
DTYVQV
SW
EQ
AL
KL
I
HEQ
H
D
RI
R
K
A
N
G
PS
A
I
F
--
-
-
AG
SY
G
WR
S
S
G
V
LHK
A
QT
L
LQ
R
Y
MN
LA
GG
Y
S
GH
S
G
D
YST
GAAQ
V
I
MP
H
VV
GS
VEVYEQQTSW
P
L
IL
ENS
QV
VV
LW
G
M
NP
LN
T
LKIAWSSTDEQ
GL
E
Y
F-
-
H
QLK
KS
GK
P
V
I
A
IDP
IR
S
E
T
IEFF
D
DNAT
W
IAPNM
GTD
V
AL
ML
GIA
HT
L
M
T
QG
K
H
D
KV
FL
E
KY
TT
GY
PQ
-----
-
--
-
-
-
-
FEE
Y
LT
G
KS
-
D
N
T
P
K
SA
V
WAAEITG
V
P
EA
QI
V
KLA
-
E
LM
AA
NRTMLMA
GWG
I
QRQ
Q
Y
GEQ
K
H
WMLVT
L
AA
ML
G
QI
G
T
P
GG
GF
G
FSYHYSNGGNP
T
R
V
G
GV----
-
-
LP
E
M
S
AAIAG
H
A
S
-
-
-
--
E
A
A
D
D
G
G-
MTAI
PVARIV
D
ALENPGGKYQHN
GKE
QTYPN
IK
M
IW
-
W
AG
GGN
F
TH
H
Q
D
T
N
R
LIK
A
W
Q
-
-
-
K
P
EMIVV
S
E
C
YW
TA
A
AK
H
ADI
V
LP
ITT
SF
E
RN
DL
T
MTGD
YS
N
Q
-
H
I
V
PM
KQ
A
VA
P
Q
FE
ARNDFD
V
FADL
A
EL
L
K
P
GGKE
I
Y
TEG
K
D
E
MA
WLKF
F
Y
DAAQKG
AR
AQ
R
V
T
MP
M
F
N
A
F
W
QQ
NK
L
IEMR
H
S
E
K
NE
Q
YV
R
Y
G
D
FR
A
DP
V
K
N
A
L
G
TPSGKIEIYS
KT
L
E
K
FGYKDCPAH
P
TW
--
-
---
-
L
A
P
--
-
-
---
-
D
E
W
K
G
T
A
D
E
K
-
Q
LQL
L
TA
H
PA
H
R
L
HS
Q
LNYA
E
L
R
K
K
YA
I
A
D
R
EPIT
I
HTE
DA
A
R
F
GIANGD
L
VRV
W
N
K
RG
Q
IL
TG
A
V
VT
DG
I
KK
GV
V
C
V
HE
GAW
P
D
L
E
-
-
-
N
G
L
CKN
GS
A
N
V
LTA
D
I
PS
SQ
LA
NACA
G
N
S
A
LV
Y
IEKYTGNAPKLTAFDQPAVQA
fig|511145.6.peg.1936
Escherichia coli str. K-12 substr. MG1655
MT
LT
RR
E
F
IK
H
S
G
I
AAG
AL
-
---
-
-
---
-
--
V
V
T
S
AAP
LP
AW
A
E
EK
-
--
G
G
K
I
LTA
G
RWG
A
MNVE
VKD
GK
I
-
---
V
S
STG
A
-
-
-
-
LAKTIPNS
L
QSTAADQVHTTA
RI
Q
HP
MVRKSY
L
D
N
P
LQPAKG
RGE
DTYVQV
SW
EQ
AL
KL
I
HEQ
H
D
RI
R
K
A
N
G
PS
A
I
F
--
-
-
AG
SY
G
WR
S
S
G
V
LHK
A
QT
L
LQ
R
Y
MN
LA
GG
Y
S
GH
S
G
D
YST
GAAQ
V
I
MP
H
VV
GS
VEVYEQQTSW
P
L
IL
ENS
QV
VV
LW
G
M
NP
LN
T
LKIAWSSTDEQ
GL
E
Y
F-
-
H
QLK
KS
GK
P
V
I
A
IDP
IR
S
E
T
IEFF
D
DNAT
W
IAPNM
GTD
V
AL
ML
GIA
HT
L
M
T
QG
K
H
D
KV
FL
E
KY
TT
GY
PQ
-----
-
--
-
-
-
-
FEE
Y
LT
G
KS
-
D
N
T
P
K
SA
V
WAAEITG
V
P
EA
QI
V
KLA
-
E
LM
AA
NRTMLMA
GWG
I
QRQ
Q
Y
GEQ
K
H
WMLVT
L
AA
ML
G
QI
G
T
P
GG
GF
G
FSYHYSNGGNP
T
R
V
G
GV----
-
-
LP
E
M
S
AAIAG
H
A
S
-
-
-
--
E
A
A
D
D
G
G-
MTAI
PVARIV
D
ALENPGGKYQHN
GKE
QTYPN
IK
M
IW
-
W
AG
GGN
F
TH
H
Q
D
T
N
R
LIK
A
W
Q
-
-
-
K
P
EMIVV
S
E
C
YW
TA
A
AK
H
ADI
V
LP
ITT
SF
E
RN
DL
T
MTGD
YS
N
Q
-
H
I
V
PM
KQ
A
VA
P
Q
FE
ARNDFD
V
FADL
A
EL
L
K
P
GGKE
I
Y
TEG
K
D
E
MA
WLKF
F
Y
DAAQKG
AR
AQ
R
V
T
MP
M
F
N
A
F
W
QQ
NK
L
IEMR
H
S
E
K
NE
Q
YV
R
Y
G
D
FR
A
DP
V
K
N
A
L
G
TPSGKIEIYS
KT
L
E
K
FGYKDCPAH
P
TW
--
-
---
-
L
A
P
--
-
-
---
-
D
E
W
K
G
T
A
D
E
K
-
Q
LQL
L
TA
H
PA
H
R
L
HS
Q
LNYA
E
L
R
K
K
YA
I
A
D
R
EPIT
I
HTE
DA
A
R
F
GIANGD
L
VRV
W
N
K
RG
Q
IL
TG
A
V
VT
DG
I
KK
GV
V
C
V
HE
GAW
P
D
L
E
-
-
-
N
G
L
CKN
GS
A
N
V
LTA
D
I
PS
SQ
LA
NACA
G
N
S
A
LV
Y
IEKYTGNAPKLTAFDQPAVQA
fig|656444.3.peg.2806
Escherichia coli TA280
MT
LT
RR
E
F
IK
H
S
G
I
AAG
AL
-
---
-
-
---
-
--
V
V
T
S
AAP
LP
AW
A
E
EK
-
--
G
G
K
I
LTA
G
RWG
A
MNVE
VKD
GK
I
-
---
V
S
STG
A
-
-
-
-
LAKTIPNS
L
QSTAADQVHTTA
RI
Q
HP
MVRKSY
L
D
N
P
LQPAKG
RGE
DTYVQV
SW
EQ
AL
KL
I
HEQ
H
D
RI
R
K
A
N
G
PS
A
I
F
--
-
-
AG
SY
G
WR
S
S
G
V
LHK
A
QT
L
LQ
R
Y
MN
LA
GG
Y
S
GH
S
G
D
YST
GAAQ
V
I
MP
H
VV
GS
VEVYEQQTSW
P
L
IL
ENS
QV
VV
LW
G
M
NP
LN
T
LKIAWSSTDEQ
GL
E
Y
F-
-
H
QLK
KS
GK
P
V
I
A
IDP
IR
S
E
T
IEFF
G
DNAT
W
IAPNM
GTD
V
AL
ML
GIA
HT
L
M
T
Q
S
K
H
D
KV
FL
E
KY
TT
GY
PQ
-----
-
--
-
-
-
-
FEE
Y
LT
G
KS
-
D
N
T
P
K
SA
A
WAAEITG
V
P
EA
QI
V
KLA
-
E
LM
AA
NRTMLMA
GWG
I
QRQ
Q
Y
GEQ
K
H
WMLVT
L
AA
ML
G
QI
G
T
P
GG
GF
G
FSYHYSNGGNP
T
R
V
G
GV----
-
-
LP
E
M
S
AAIAG
Q
A
S
-
-
-
--
E
A
A
D
D
G
G-
MTAI
PVARIV
D
ALENPGGKYQHN
GKE
QTYPN
IK
M
IW
-
W
AG
GGN
F
TH
H
Q
D
T
N
R
LIK
A
W
Q
-
-
-
K
P
EMIVV
S
E
C
YW
TA
A
AK
H
ADI
V
LP
ITT
SF
E
RN
DL
T
MTGD
YS
N
Q
-
H
I
V
PM
KQVVA
A
Q
FE
ARNDFD
V
FADL
A
EL
L
K
P
GGKE
I
Y
TEGR
D
E
MA
WLKF
F
Y
DAAQKG
AR
AQ
R
V
T
MP
M
F
N
A
F
W
QQ
NK
L
IEMR
R
S
E
K
NE
Q
YV
R
Y
G
D
FR
A
DP
V
K
N
A
L
G
TPSGKIEIYS
KT
L
E
K
FGYKDCPAH
P
TW
--
-
---
-
L
A
P
--
-
-
---
-
D
E
W
K
G
S
A
D
E
K
-
Q
LQL
L
TA
H
PA
H
R
L
HS
Q
LNYA
E
L
R
K
K
YAV
A
D
R
EPIT
I
HTE
DA
A
R
F
GIANGD
L
VRV
W
N
K
RG
Q
IL
TG
A
V
VT
DG
I
KK
GV
V
C
V
HE
GAW
P
D
L
E
-
-
-
N
G
L
CKN
GS
A
N
V
LTA
D
I
PS
SQ
LA
NACA
G
N
S
A
LV
Y
IEKYTGNAPKLTAFDQPAVQA
fig|439855.10.peg.1471
Escherichia coli SMS-3-5
MT
LT
RR
E
F
IK
H
S
G
I
AAG
AL
-
---
-
-
---
-
--
V
V
T
S
AAP
LP
AW
A
E
EK
-
--
G
G
K
I
LTA
G
RWG
A
MNVE
VKD
GK
I
-
---
V
S
STG
A
-
-
-
-
LAKTIPNS
L
QSTAADQVHTTA
RI
Q
HP
MVRKSY
L
D
N
P
LQPAKG
RGE
D
I
YVQV
SW
EQ
AL
KL
I
HEQ
H
D
RI
R
K
A
N
G
PS
A
I
F
--
-
-
AG
SY
G
WR
S
S
G
V
LHK
A
QT
L
LQ
R
Y
MN
LA
GG
Y
S
GH
S
G
D
YST
GAAQ
V
I
MP
H
VV
GS
VEVYEQQTSW
P
L
IL
ENS
QV
VV
LW
G
M
NP
LN
T
LKIAWSSTDEQ
GL
E
Y
F-
-
H
QLK
KS
GK
P
V
I
A
IDP
IR
S
E
T
IEFF
G
DNAT
W
IAPNM
GTD
V
AL
ML
GIA
HT
L
M
V
QG
K
H
D
K
A
FL
E
KY
TT
GY
PQ
-----
-
--
-
-
-
-
FEE
Y
L
I
G
KS
-
D
N
T
P
K
SA
A
WAAEITG
V
P
EA
QI
V
KLA
-
E
LM
AA
NRTMLMA
GWG
I
QRQ
Q
Y
GEQ
K
H
WMLVT
L
AA
ML
G
QI
G
T
P
GG
GF
G
FSYHYSNGGNP
T
R
V
G
GV----
-
-
LP
E
M
S
AAIAG
Q
A
S
-
-
-
--
E
A
A
D
D
G
G-
MTAI
PVARIV
D
ALENPGGKYQHN
GKE
QTYPN
IK
M
IW
-
W
AG
GGN
F
TH
H
Q
D
T
N
R
LIK
A
W
Q
-
-
-
K
P
EMIVV
S
E
C
YW
TA
A
AK
H
ADI
V
LP
ITT
SF
E
RN
DL
T
MTGD
YS
N
Q
-
H
I
V
PM
KQ
A
VA
P
Q
FE
ARNDFD
V
FADL
A
EL
L
K
P
GGKE
I
Y
TEG
K
D
E
MA
WLKF
F
Y
DAAQKG
AR
AQ
R
V
T
MP
M
F
N
A
F
W
QQ
NK
L
IEMR
R
S
E
K
NE
Q
YV
R
Y
G
D
FR
A
DP
V
K
N
A
L
G
TPSGKIEIYS
KT
L
E
K
FGYKDCPAH
P
TW
--
-
---
-
L
A
P
--
-
-
---
-
D
E
W
K
G
T
A
D
E
K
-
Q
LQL
L
TA
H
PA
H
R
L
HS
Q
LNYA
E
L
R
K
K
YAV
A
D
R
EPIT
I
HTE
DA
A
R
F
GIANGD
L
VRV
W
N
K
RG
Q
IL
TG
A
V
VT
DG
I
KK
GV
V
C
V
HE
GAW
P
D
L
E
-
-
-
S
G
L
CKN
GS
A
N
V
LTA
D
I
PS
SQ
LA
NACA
G
N
S
A
LV
Y
IEKYTGNAPKLTAFDQPAVQA
fig|331111.12.peg.2381
Escherichia coli E24377A
MT
LT
RR
E
F
IK
H
S
G
I
AAG
AL
-
---
-
-
---
-
--
V
V
T
S
AAP
LP
AW
A
E
EK
-
--
G
G
K
I
LTA
G
RWG
A
M
S
VE
VKD
GK
I
-
---
V
S
STG
A
-
-
-
-
LAKTIPNS
L
QSTAADQVHTTA
RI
Q
HP
MVRKSY
L
D
N
P
LQPAKG
RGE
DTYVQV
SW
EQ
AL
KL
I
HEQ
H
D
RI
R
K
A
N
G
PS
A
I
F
--
-
-
AG
SY
G
WR
S
S
G
V
LHK
A
QT
L
LQ
R
Y
MN
LA
GG
Y
S
GH
S
G
D
YST
GAAQ
V
I
MP
H
VV
GS
VEVYEQQTSW
P
L
IL
ENS
QV
VV
LW
G
M
NP
LN
T
LKIAWSSTDEQ
GL
E
Y
F-
-
H
QLK
KS
GK
P
V
I
A
IDP
IR
S
E
T
I
D
FF
G
DNAT
W
IAPNM
GTD
V
AL
ML
GIA
HT
L
M
T
QG
K
H
D
KV
FL
E
KY
TT
GY
PQ
-----
-
--
-
-
-
-
FEE
Y
LT
G
KS
-
D
N
T
P
K
SA
A
WAAEITG
V
P
EA
QI
V
KLA
-
E
LM
AA
NRTMLMA
GWG
I
QRQ
Q
Y
GEQ
K
H
WMLVT
L
AA
ML
G
QI
G
T
P
GG
GF
G
FSYHYSNGGNP
T
R
V
G
GV----
-
-
LP
E
M
S
AAIAG
Q
A
S
-
-
-
--
E
A
A
D
D
G
G-
MTAI
T
VARIV
D
ALENPGGKYQHN
GKE
QTYPN
IK
M
IW
-
W
AG
GGN
F
TH
H
Q
D
T
N
R
LIK
A
W
Q
-
-
-
K
P
EMIVV
S
E
C
YW
TA
A
AK
H
ADI
V
LP
ITT
SF
E
RN
DL
T
MTGD
YS
N
Q
-
H
I
V
PM
KQ
A
VA
P
Q
FE
ARNDFD
V
FADL
A
EL
L
K
P
GGKE
I
Y
TEG
K
D
E
MA
WLKF
F
Y
DAAQKG
AR
AQ
R
V
T
MP
M
F
N
V
F
W
QQ
NK
L
IEMR
R
S
E
K
NE
Q
YV
R
Y
G
D
FR
A
DP
V
K
N
A
L
G
TPSGKIEIYS
KT
L
E
K
FGYKDCPAH
P
TW
--
-
---
-
L
A
P
--
-
-
---
-
D
E
W
K
G
T
A
D
E
K
-
Q
LQL
L
TA
H
PA
H
R
L
HS
Q
LNYA
E
L
R
K
K
YAV
A
D
R
EPIT
I
HTE
DA
A
R
F
GIANGD
L
VRV
W
N
K
RG
Q
IL
TG
A
V
VT
DG
I
KK
GV
V
C
V
HE
GAW
P
D
L
E
-
-
-
N
G
L
CKN
GS
A
N
V
LTA
D
I
PS
SQ
LA
NACA
G
N
S
A
LV
Y
IEKYTGNAPKLTAFD
K
PAVQA
fig|331111.3.peg.4520
Escherichia coli E24377A
MT
LT
RR
E
F
IK
H
S
G
I
AAG
AL
-
---
-
-
---
-
--
V
V
T
S
AAP
LP
AW
A
E
EK
-
--
G
G
K
I
LTA
G
RWG
A
M
S
VE
VKD
GK
I
-
---
V
S
STG
A
-
-
-
-
LAKTIPNS
L
QSTAADQVHTTA
RI
Q
HP
MVRKSY
L
D
N
P
LQPAKG
RGE
DTYVQV
SW
EQ
AL
KL
I
HEQ
H
D
RI
R
K
A
N
G
PS
A
I
F
--
-
-
AG
SY
G
WR
S
S
G
V
LHK
A
QT
L
LQ
R
Y
MN
LA
GG
Y
S
GH
S
G
D
YST
GAAQ
V
I
MP
H
VV
GS
VEVYEQQTSW
P
L
IL
ENS
QV
VV
LW
G
M
NP
LN
T
LKIAWSSTDEQ
GL
E
Y
F-
-
H
QLK
KS
GK
P
V
I
A
IDP
IR
S
E
T
I
D
FF
G
DNAT
W
IAPNM
GTD
V
AL
ML
GIA
HT
L
M
T
QG
K
H
D
KV
FL
E
KY
TT
GY
PQ
-----
-
--
-
-
-
-
FEE
Y
LT
G
KS
-
D
N
T
P
K
SA
A
WAAEITG
V
P
EA
QI
V
KLA
-
E
LM
AA
NRTMLMA
GWG
I
QRQ
Q
Y
GEQ
K
H
WMLVT
L
AA
ML
G
QI
G
T
P
GG
GF
G
FSYHYSNGGNP
T
R
V
G
GV----
-
-
LP
E
M
S
AAIAG
Q
A
S
-
-
-
--
E
A
A
D
D
G
G-
MTAI
T
VARIV
D
ALENPGGKYQHN
GKE
QTYPN
IK
M
IW
-
W
AG
GGN
F
TH
H
Q
D
T
N
R
LIK
A
W
Q
-
-
-
K
P
EMIVV
S
E
C
YW
TA
A
AK
H
ADI
V
LP
ITT
SF
E
RN
DL
T
MTGD
YS
N
Q
-
H
I
V
PM
KQ
A
VA
P
Q
FE
ARNDFD
V
FADL
A
EL
L
K
P
GGKE
I
Y
TEG
K
D
E
MA
WLKF
F
Y
DAAQKG
AR
AQ
R
V
T
MP
M
F
N
V
F
W
QQ
NK
L
IEMR
R
S
E
K
NE
Q
YV
R
Y
G
D
FR
A
DP
V
K
N
A
L
G
TPSGKIEIYS
KT
L
E
K
FGYKDCPAH
P
TW
--
-
---
-
L
A
P
--
-
-
---
-
D
E
W
K
G
T
A
D
E
K
-
Q
LQL
L
TA
H
PA
H
R
L
HS
Q
LNYA
E
L
R
K
K
YAV
A
D
R
EPIT
I
HTE
DA
A
R
F
GIANGD
L
VRV
W
N
K
RG
Q
IL
TG
A
V
VT
DG
I
KK
GV
V
C
V
HE
GAW
P
D
L
E
-
-
-
N
G
L
CKN
GS
A
N
V
LTA
D
I
PS
SQ
LA
NACA
G
N
S
A
LV
Y
IEKYTGNAPKLTAFD
K
PAVQA
fig|562.373.peg.5648
Escherichia coli 1125A
MT
LT
RR
E
F
IK
H
S
G
I
AAG
AL
-
---
-
-
---
-
--
V
V
T
S
AAP
LP
AW
A
E
EK
-
--
G
G
K
I
LTA
G
RWG
A
MNVE
VKD
GK
I
-
---
V
S
STG
A
-
-
-
-
LAKTIPNS
L
QSTAADQVHTTA
RI
Q
HP
MVRKSY
L
D
N
P
LQPAKG
RGE
DTYVQV
SW
EQ
AL
KL
I
HEQ
H
E
RI
R
K
A
N
G
PS
A
I
F
--
-
-
AG
SY
G
WR
S
S
G
V
LHK
A
QT
L
LQ
R
Y
MN
LA
GG
Y
S
GH
S
G
D
YST
GAAQ
V
I
MP
H
VV
GS
VEVYEQQTSW
P
L
IL
ENS
QV
VV
LW
G
M
NP
LN
T
LKIAWSSTDEQ
GL
E
Y
F-
-
H
QLK
KS
GK
P
V
I
A
IDP
IR
S
E
T
IEFF
G
Y
NAT
W
IAPNM
GTD
V
AL
ML
GIA
HT
L
M
T
QG
K
H
D
KV
FL
E
KY
TT
GY
PQ
-----
-
--
-
-
-
-
FEE
Y
LT
G
KS
-
D
N
T
P
K
SA
A
W
T
AEITG
V
P
EA
QI
V
KLA
-
E
LM
AA
NRTMLMA
GWG
I
QRQ
Q
Y
GEQ
K
H
WMLVT
L
AA
ML
G
QI
G
T
P
GG
GF
G
FSYHYSNGGNP
T
R
V
G
GV----
-
-
LP
E
M
S
AAIAG
Q
A
S
-
-
-
--
E
A
A
D
D
G
G-
MTAI
PVARIV
D
ALENPGGKYQHN
GKE
QTYPN
IK
M
IW
-
W
AG
GGN
F
TH
H
Q
D
T
N
R
LIK
A
W
Q
-
-
-
K
P
EMIVV
S
E
C
YW
TA
A
AK
H
ADI
V
LP
ITT
SF
E
RN
DL
T
MTGD
YS
N
Q
-
H
I
V
PM
KQ
A
VA
P
Q
FE
ARNDFD
V
FA
E
L
A
EL
L
K
P
GGKE
I
Y
TEG
K
D
E
MA
WLKF
F
Y
DAAQKG
AR
AQ
R
V
T
MP
M
F
N
A
F
W
QQ
NK
L
IEMR
R
S
E
K
NE
Q
YV
R
Y
G
D
FR
A
DP
V
K
N
A
L
G
TPSGKIEIYS
KT
L
E
K
FGYKDCPAH
P
TW
--
-
---
-
L
A
P
--
-
-
---
-
D
E
W
K
G
T
A
D
E
K
-
Q
LQL
L
TA
H
PA
H
C
L
HS
Q
LNYA
Q
L
R
K
K
YAV
A
D
R
EPIT
I
HTE
DA
A
R
F
GIANGD
L
VRV
W
N
K
RG
Q
IL
TG
A
V
VT
DG
I
KK
GV
V
C
V
HE
GAW
P
D
L
E
-
-
-
N
G
L
CKN
GS
A
N
V
LTA
D
I
PS
SQ
LA
NACA
G
N
S
A
LV
Y
IEKYTGNAPKLTAFDQPAVQA
fig|525281.3.peg.622
Escherichia coli 83972
MT
LT
RR
E
F
IK
H
S
G
I
AAG
T
L
-
---
-
-
---
-
--
V
V
T
S
AAP
LP
AW
A
E
EK
-
--
G
G
K
I
LTA
G
RWG
A
MNVE
VKD
GK
I
-
---
V
S
STG
A
-
-
-
-
LAKTIPNS
L
QSTAADQVHTTA
RI
Q
HP
MVRKSY
L
D
N
P
LQP
V
KG
RGE
DTYVQV
SW
EQ
AL
KL
I
HEQ
H
D
RI
R
K
A
N
G
PS
A
I
F
--
-
-
AG
SY
G
WR
S
S
G
V
LHK
A
QT
L
LQ
R
Y
MN
LA
GG
Y
S
GH
S
G
D
YST
GAAQ
V
I
MP
H
VV
GS
VEVYEQQTSW
P
L
IL
ENS
QV
VV
LW
G
M
NP
LN
T
LKIAWSSTDEQ
GL
E
Y
F-
-
H
QLK
KS
GK
P
V
I
A
IDP
IR
S
E
T
IEFF
G
DNAT
W
IAPNM
GTD
V
AL
ML
GIA
HT
L
M
T
QG
K
H
D
KV
FL
E
KY
TT
GY
PQ
-----
-
--
-
-
-
-
FEE
Y
LT
G
KS
-
D
N
T
P
K
SA
A
WAAEITG
V
P
EA
QI
V
KLA
-
E
LM
AA
NRTMLMA
GWG
I
QRQ
Q
Y
GEQ
K
H
WMLVT
L
AA
ML
G
QI
G
T
P
GG
GF
G
FSYHYSNGGNP
T
R
V
G
GV----
-
-
LP
E
M
S
AAIAG
Q
A
S
-
-
-
--
E
A
A
D
D
G
G-
MTAI
PVARIV
D
ALENPGGKYQHN
GKE
QTYPN
IK
M
IW
-
W
AG
GGN
F
TH
H
Q
D
T
N
R
LIK
A
W
Q
-
-
-
K
P
EMIVV
S
E
C
YW
TA
A
AK
H
ADI
V
LP
ITT
SF
E
RN
DL
T
MTGD
YS
N
Q
-
H
I
V
PM
KQ
A
VA
P
Q
FE
ARNDFD
V
FADL
A
EL
L
K
P
GGKE
I
Y
TEG
K
D
E
MA
WLKF
F
Y
DAAQKG
AR
AQ
R
V
T
MP
M
F
N
A
F
W
QQ
NK
L
IEMR
R
S
E
K
NE
Q
Y
I
R
Y
G
D
FR
A
DP
V
K
N
A
L
G
TPSGKIEIYS
RT
L
E
K
FGYKDCPAH
P
TW
--
-
---
-
L
A
P
--
-
-
---
-
EE
W
K
G
T
A
D
E
K
-
Q
LQL
L
TA
H
PA
H
R
L
HS
Q
LNYA
E
L
R
K
K
YAV
A
D
R
EPIT
I
HTE
DA
A
R
F
GIANGD
L
VRV
W
N
K
RG
Q
IL
TG
A
V
VT
DG
I
KK
GV
V
C
V
HE
GAW
P
D
L
E
-
-
-
N
G
L
CKN
GS
A
N
V
LTA
D
I
PS
SQ
LA
NACA
G
N
S
A
LV
Y
IEKYTGNA
L
KLTAFDQPAVQA
fig|655817.3.peg.2233
Escherichia coli ABU 83972
MT
LT
RR
E
F
IK
H
S
G
I
AAG
T
L
-
---
-
-
---
-
--
V
V
T
S
AAP
LP
AW
A
E
EK
-
--
G
G
K
I
LTA
G
RWG
A
MNVE
VKD
GK
I
-
---
V
S
STG
A
-
-
-
-
LAKTIPNS
L
QSTAADQVHTTA
RI
Q
HP
MVRKSY
L
D
N
P
LQP
V
KG
RGE
DTYVQV
SW
EQ
AL
KL
I
HEQ
H
D
RI
R
K
A
N
G
PS
A
I
F
--
-
-
AG
SY
G
WR
S
S
G
V
LHK
A
QT
L
LQ
R
Y
MN
LA
GG
Y
S
GH
S
G
D
YST
GAAQ
V
I
MP
H
VV
GS
VEVYEQQTSW
P
L
IL
ENS
QV
VV
LW
G
M
NP
LN
T
LKIAWSSTDEQ
GL
E
Y
F-
-
H
QLK
KS
GK
P
V
I
A
IDP
IR
S
E
T
IEFF
G
DNAT
W
IAPNM
GTD
V
AL
ML
GIA
HT
L
M
T
QG
K
H
D
KV
FL
E
KY
TT
GY
PQ
-----
-
--
-
-
-
-
FEE
Y
LT
G
KS
-
D
N
T
P
K
SA
A
WAAEITG
V
P
EA
QI
V
KLA
-
E
LM
AA
NRTMLMA
GWG
I
QRQ
Q
Y
GEQ
K
H
WMLVT
L
AA
ML
G
QI
G
T
P
GG
GF
G
FSYHYSNGGNP
T
R
V
G
GV----
-
-
LP
E
M
S
AAIAG
Q
A
S
-
-
-
--
E
A
A
D
D
G
G-
MTAI
PVARIV
D
ALENPGGKYQHN
GKE
QTYPN
IK
M
IW
-
W
AG
GGN
F
TH
H
Q
D
T
N
R
LIK
A
W
Q
-
-
-
K
P
EMIVV
S
E
C
YW
TA
A
AK
H
ADI
V
LP
ITT
SF
E
RN
DL
T
MTGD
YS
N
Q
-
H
I
V
PM
KQ
A
VA
P
Q
FE
ARNDFD
V
FADL
A
EL
L
K
P
GGKE
I
Y
TEG
K
D
E
MA
WLKF
F
Y
DAAQKG
AR
AQ
R
V
T
MP
M
F
N
A
F
W
QQ
NK
L
IEMR
R
S
E
K
NE
Q
Y
I
R
Y
G
D
FR
A
DP
V
K
N
A
L
G
TPSGKIEIYS
RT
L
E
K
FGYKDCPAH
P
TW
--
-
---
-
L
A
P
--
-
-
---
-
EE
W
K
G
T
A
D
E
K
-
Q
LQL
L
TA
H
PA
H
R
L
HS
Q
LNYA
E
L
R
K
K
YAV
A
D
R
EPIT
I
HTE
DA
A
R
F
GIANGD
L
VRV
W
N
K
RG
Q
IL
TG
A
V
VT
DG
I
KK
GV
V
C
V
HE
GAW
P
D
L
E
-
-
-
N
G
L
CKN
GS
A
N
V
LTA
D
I
PS
SQ
LA
NACA
G
N
S
A
LV
Y
IEKYTGNA
L
KLTAFDQPAVQA
fig|749548.3.peg.4800
Escherichia coli MS 196-1
MT
LT
RR
E
F
IK
H
S
G
I
AAG
AL
-
---
-
-
---
-
--
V
V
T
S
AAP
LP
AW
A
E
EK
-
--
G
G
K
I
LTA
G
RWG
A
MNVE
VKD
GK
I
-
---
V
S
STG
A
-
-
-
-
LAKTIPNS
L
QSTAADQVHTTA
RI
Q
HP
MVRKSY
L
D
N
P
LQPAKG
RGE
DTYVQV
SW
EQ
AL
KL
I
HEQ
H
D
RI
R
K
A
N
G
PS
A
I
F
--
-
-
AG
SY
G
WR
S
S
G
V
LHK
A
QT
L
LQ
R
Y
MN
LA
GG
Y
S
GH
S
G
D
YST
GAAQ
V
I
MP
H
VV
GS
VEVYEQQTSW
P
L
IL
ENS
QV
VV
LW
G
M
NP
LN
T
LKIAWSSTDEQ
GL
E
Y
F-
-
H
QLK
KS
GK
P
V
I
A
IDP
IR
S
E
T
IEFF
D
DNAT
W
IAPNM
GTD
V
AL
ML
GIA
HT
L
M
T
QG
K
H
D
KV
FL
E
KY
TT
GY
PQ
-----
-
--
-
-
-
-
FEE
Y
LT
G
KS
-
D
N
T
P
K
SA
V
WAAEITG
V
P
EA
QI
V
KLA
-
E
LM
AA
NRTMLMA
GWG
I
QRQ
Q
Y
GEQ
K
H
WMLVT
L
AA
ML
G
QI
G
T
P
GG
GF
G
FSYHYSNGGNP
T
R
V
G
GV----
-
-
LP
E
M
S
AAIAG
H
A
S
-
-
-
--
E
A
A
D
D
G
G-
MTAI
PVARIV
D
ALENPGGKYQHN
GKE
QTYPN
IK
M
IW
-
W
AG
GGN
F
TH
H
Q
D
T
N
R
LIK
A
W
Q
-
-
-
K
P
EMIVV
S
E
C
YW
TA
A
AK
H
ADI
V
LP
ITT
SF
E
RN
DL
T
MTGD
YS
N
Q
-
H
I
V
PM
KQ
A
VA
P
Q
FE
ARNDFD
V
FADL
A
EL
L
K
P
GGKE
I
Y
TEG
K
D
E
MA
WLKF
F
Y
DAAQKG
AR
AQ
R
V
T
MP
M
F
N
A
F
W
QQ
NK
L
IEMR
R
S
E
K
S
E
Q
YV
R
Y
G
D
FR
A
DP
V
K
N
A
L
G
TPSGKIEIYS
KT
L
E
K
FGYKDCPAH
P
TW
--
-
---
-
L
A
P
--
-
-
---
-
D
E
W
K
G
T
A
D
E
K
-
Q
LQL
L
TA
H
PA
H
R
L
HS
Q
LNYA
E
L
R
K
K
YA
I
A
D
R
EPIT
I
HTE
DA
A
R
F
GI
V
NGD
L
VRV
W
N
K
RG
Q
IL
TG
A
V
VT
DG
I
KK
GV
V
C
V
HE
GAW
P
D
L
E
-
-
-
N
G
L
CKN
GS
A
N
V
LTA
D
I
PS
SQ
LA
NACA
G
N
S
A
LV
Y
IEKYTGNAPKLTAFDQPAVQA
fig|749537.3.peg.1303
Escherichia coli MS 115-1
MT
LT
RR
E
F
IK
H
S
G
I
AAG
AL
-
---
-
-
---
-
--
V
V
T
S
AAP
LP
AW
A
E
EK
-
--
G
G
K
I
LTA
G
RWG
A
MNVE
VKD
GK
I
-
---
V
S
STG
A
-
-
-
-
LAKTIPNS
L
QSTAADQVHTT
T
RI
Q
HP
MVRKSY
L
D
N
P
LQP
T
KG
RGE
DTYVQV
SW
EQ
AL
KL
I
HEQ
H
D
RI
R
K
A
N
G
PS
A
I
F
--
-
-
AG
SY
G
WR
S
S
G
V
LHK
A
QT
L
LQ
R
Y
MN
LA
GG
Y
S
GH
S
G
D
YST
GAAQ
V
I
MP
H
VV
GS
VEVYEQQTSW
P
L
IL
ENS
QV
VV
LW
G
M
NP
LN
T
LKIAWSSTDEQ
GL
E
Y
F-
-
H
QLK
KS
GK
P
V
I
A
IDP
IR
S
E
T
I
D
FF
G
DNAT
W
IAPNM
GTD
V
AL
ML
GIA
HT
L
M
T
QG
K
H
D
KV
FL
E
KY
TT
GY
PQ
-----
-
--
-
-
-
-
FEE
Y
L
R
G
KS
-
D
N
T
P
K
SA
A
WAAEITG
V
P
EA
QI
V
KLA
-
E
LM
AA
NRTMLMA
GWG
I
QRQ
Q
Y
GEQ
K
H
WMLVT
L
AA
ML
G
QI
G
T
P
GG
GF
G
FSYHYSNGGNP
T
R
V
G
GV----
-
-
LP
E
M
S
AAIAG
Q
A
S
-
-
-
--
E
A
A
D
D
G
G-
M
R
AI
PVARIV
D
ALENPGGKYQHN
GKE
QTYPN
IK
M
IW
-
W
AG
GGN
F
TH
H
Q
D
T
N
R
LIK
A
W
Q
-
-
-
K
P
EMIVV
S
E
C
YW
TA
A
AK
H
ADI
V
LP
ITT
SF
E
RN
DL
T
MTGD
YS
N
Q
-
H
I
V
PM
KQ
A
VA
P
Q
FE
ARNDFD
V
FADL
A
EL
L
K
P
GGKE
I
Y
TEG
K
D
E
MA
WLKF
F
Y
DAAQKG
AR
AQ
R
V
T
MP
M
F
N
A
F
W
QQ
NK
L
IEMR
R
S
E
K
NE
Q
YV
R
Y
G
D
FR
A
DP
V
K
N
A
L
G
TPSGKIEIYS
KT
L
E
K
FGYKDCPAH
P
TW
--
-
---
-
L
A
P
--
-
-
---
-
D
E
W
K
G
T
A
D
E
K
-
Q
LQL
L
TA
H
PA
H
R
L
HS
Q
LNYA
E
L
R
K
K
YAV
A
D
R
EPIT
I
HTE
DA
A
R
F
GIANGD
L
VRV
W
N
K
RG
Q
IL
TG
A
V
VT
DG
I
KK
GV
V
C
V
HE
GAW
P
D
L
E
-
-
-
N
G
L
CKN
GS
A
N
V
LTA
D
I
PS
SQ
LA
NACA
G
N
S
A
LV
Y
IEKYTGNAPKLTAFD
K
PAVQA
fig|670897.3.peg.2758
Escherichia coli 2362-75
MT
LT
RR
E
F
IK
H
S
G
I
AAG
T
L
-
---
-
-
---
-
--
V
V
T
S
AAP
LP
AW
A
E
EK
-
--
G
G
K
I
LTA
G
RWG
A
MNVE
VKD
GK
I
-
---
V
S
STG
A
-
-
-
-
LAKTIPNS
L
QSTAADQVHTTA
RI
Q
HP
MVRKSY
L
D
N
P
LQPAKG
RGE
DTYVQV
SW
EQ
AL
KL
I
HEQ
H
D
RI
R
K
A
N
G
PS
A
I
F
--
-
-
AG
SY
G
WR
S
S
G
V
LHK
A
QT
L
LQ
R
Y
MN
LA
GG
Y
S
GH
S
G
D
YST
GAAQ
V
I
MP
H
VV
GS
VEVYEQQTSW
P
L
IL
ENS
QV
VV
LW
G
M
NP
LN
T
LKIAWSSTDEQ
GL
E
Y
F-
-
H
QLK
KS
GK
P
V
I
A
IDP
IR
S
E
T
IEFF
G
DNAT
W
IAPNM
GTD
V
AL
ML
GIA
HT
L
M
T
QG
K
H
D
KV
FL
E
KY
TT
GY
PQ
-----
-
--
-
-
-
-
FEE
Y
LT
G
KS
-
D
N
T
P
K
SA
A
WAAEITG
V
P
EA
QI
V
KLA
-
E
LM
AA
NRTMLMA
GWG
I
QRQ
Q
Y
GEQ
K
H
WMLVT
L
AA
ML
G
QI
G
T
P
GG
GF
G
FSYHYSNGGNP
T
R
V
G
GV----
-
-
LP
E
M
S
AAIAG
Q
A
S
-
-
-
--
E
A
A
D
D
G
G-
MTAI
PVARIV
D
ALENPGGKYQHN
GKE
QTYPN
IK
M
IW
-
W
AG
GGN
F
TH
H
Q
D
T
N
R
LIK
A
R
Q
-
-
-
K
P
EMIVV
S
E
C
YW
TA
A
AK
H
ADI
V
LP
ITT
SF
E
RN
DL
T
MTGD
YS
N
Q
-
H
I
V
PM
KQ
A
VA
A
Q
FE
ARNDFD
V
FADL
A
EL
L
K
P
GGKE
I
Y
TEG
K
D
E
MA
WLKF
F
Y
DAAQKG
AR
AQ
R
V
T
MP
M
F
N
A
F
W
QQ
NK
L
IEMR
R
S
E
K
NE
Q
Y
I
R
Y
G
D
FR
A
DP
V
K
N
A
L
G
TPSGKIEIYS
RT
L
E
K
FGYKDCPAH
P
TW
--
-
---
-
L
A
P
--
-
-
---
-
D
E
W
K
G
T
A
D
E
K
-
Q
LQL
L
TA
H
PA
H
R
L
HS
Q
LNYA
E
L
R
K
K
YAV
A
D
R
EPIT
I
HTE
DA
A
R
F
GIANGD
L
VRV
W
N
K
RG
Q
IL
TG
A
V
VT
DG
I
KK
GV
V
C
V
HE
GAW
P
D
L
E
-
-
-
N
G
L
CKN
GS
A
N
V
LTA
D
I
PS
SQ
LA
NACA
G
N
S
A
LV
Y
IEKYTGNAPKLTAFDQPA
I
QA
fig|409438.11.peg.2261
Escherichia coli SE11
MT
LT
RR
E
F
IK
H
S
G
I
AAG
AL
-
---
-
-
---
-
--
V
V
T
S
AAP
LP
AW
A
E
EK
-
--
G
G
K
I
LTA
G
RWG
A
MNVE
VKD
GK
I
-
---
V
S
STG
A
-
-
-
-
LAKTIPNS
L
QSTAADQVHTT
T
RI
Q
HP
MVRKSY
L
D
N
P
LQP
T
KG
RGE
DTYVQV
SW
EQ
AL
KL
I
HEQ
H
D
RI
R
K
A
N
G
PS
A
I
F
--
-
-
AG
SY
G
WR
S
S
G
V
LHK
A
QT
L
LQ
R
Y
MN
LA
GG
Y
S
GH
S
G
D
YST
GAAQ
V
I
MP
H
VV
GS
VEVYEQQTSW
P
L
IL
ENS
QV
VV
LW
G
M
NP
LN
T
LKIAWSSTDEQ
GL
E
Y
F-
-
H
QLK
KS
GK
P
V
I
A
IDP
IR
S
E
T
IEFF
G
DNAT
W
IAPNM
GTD
V
AL
ML
GIA
HT
L
M
T
QG
K
H
D
KV
FL
E
KY
TT
GY
PQ
-----
-
--
-
-
-
-
FEE
Y
LT
G
KS
-
D
N
T
P
K
SA
A
WAAEITG
V
P
EA
QI
V
KLA
-
E
LM
AA
NRTMLMA
GWG
I
QRQ
Q
Y
GEQ
K
H
WMLVT
L
AA
ML
G
QI
G
T
P
GG
GF
G
FSYHYSNGGNP
T
R
V
G
GV----
-
-
LP
E
M
S
AAIAG
Q
A
S
-
-
-
--
E
A
A
D
D
G
G-
MTAI
PVARIV
D
ALENPGGKYQHN
GKE
QTYPN
IK
M
IW
-
W
AG
GGN
F
TH
H
Q
D
T
N
R
LIK
A
W
Q
-
-
-
K
P
EMIVV
S
E
C
YW
TA
A
AK
H
ADI
V
LP
ITT
SF
E
RN
DL
T
MTGD
YS
N
Q
-
H
I
V
PM
KQ
A
VA
P
Q
FE
ARNDFD
V
FADL
A
EL
L
K
P
GGKE
I
Y
TEG
K
D
E
MA
WLKF
F
Y
DAAQKG
AR
AQ
R
V
T
MP
M
F
N
A
F
W
QQ
NK
L
IEMR
S
S
E
K
NE
Q
YV
R
Y
G
D
FR
A
DP
V
K
N
A
L
G
TPSGKIEIYS
KT
L
E
K
FGYKDCPAH
P
TW
--
-
---
-
L
A
P
--
-
-
---
-
D
E
W
K
G
T
A
D
E
K
-
Q
LQL
L
TA
H
PA
H
R
L
HS
Q
LNYA
G
L
R
K
K
YAV
A
D
R
EPIT
I
HTE
DA
T
R
F
GIANGD
L
VRV
W
N
K
RG
Q
IL
TG
A
V
VT
DG
I
KK
GV
V
C
V
HE
GAW
P
D
L
E
-
-
-
N
G
L
CKN
GS
A
N
V
LTA
D
I
PS
SQ
LA
NACA
G
N
S
A
LV
Y
IEKYTGNAPKLTAFD
K
PAVQA
fig|595495.4.peg.3778
Escherichia coli KO11
MT
LT
RR
E
F
IK
H
S
G
I
AAG
AL
-
---
-
-
---
-
--
V
V
T
S
AAP
LP
AW
A
E
EK
-
--
G
G
K
I
LTA
G
RWG
A
MNVE
VKD
GK
I
-
---
V
S
STG
A
-
-
-
-
LAKTIPNS
L
QSTAADQVHTT
T
RI
Q
HP
MVRKSY
L
D
N
P
LQP
T
KG
RGE
DTYVQV
SW
EQ
AL
KL
I
HEQ
H
D
RI
R
K
A
N
G
PS
A
I
F
--
-
-
AG
SY
G
WR
S
S
G
V
LHK
A
QT
L
LQ
R
Y
MN
LA
GG
Y
S
GH
S
G
D
YST
GAAQ
V
I
MP
H
VV
GS
VEVYEQQTSW
P
L
IL
ENS
QV
VV
LW
G
M
NP
LN
T
LKIAWSSTDEQ
GL
E
Y
F-
-
H
QLK
KS
GK
P
V
I
A
IDP
IR
S
E
T
IEFF
G
DNAT
W
IAPNM
GTD
V
AL
ML
GIA
HT
L
M
T
QG
K
H
D
KV
FL
E
KY
T
I
GY
PQ
-----
-
--
-
-
-
-
FEE
Y
L
R
G
KS
-
D
N
T
P
K
SA
A
WAAEITG
V
P
EA
QI
V
KLA
-
E
LM
AA
NRTMLMA
GWG
I
QRQ
Q
Y
GEQ
K
H
WMLVT
L
AA
ML
G
QI
G
T
P
GG
GF
G
FSYHYSNGGNP
T
R
V
G
GV----
-
-
LP
E
M
S
AAIAG
Q
A
S
-
-
-
--
E
A
A
D
D
G
G-
M
R
AI
PVARIV
D
ALENPGGKYQHN
GKE
QTYPN
IK
M
IW
-
W
AG
GGN
F
TH
H
Q
D
T
N
R
LIK
A
W
Q
-
-
-
K
P
EMIVV
S
E
C
YW
TA
A
AK
H
ADI
V
LP
ITT
SF
E
RN
DL
T
MTGD
YS
N
Q
-
H
I
V
PM
KQ
A
VA
P
Q
FE
ARNDFD
V
FADL
A
EL
L
K
P
GGKE
I
Y
TEG
K
D
E
MA
WLKF
F
Y
DAAQKG
AR
AQ
R
V
T
MP
M
F
H
A
F
W
QQ
NK
L
IEMR
R
S
E
K
NE
Q
YV
R
Y
A
D
FR
A
DP
V
K
N
A
L
G
TPSGKIEIYS
KT
L
E
K
FGYKDCPAH
P
TW
--
-
---
-
L
A
P
--
-
-
---
-
D
E
W
K
G
T
A
D
E
K
-
Q
LQL
L
TA
H
PA
H
R
L
HS
Q
LNYA
E
L
R
K
K
YAV
A
D
R
EPIT
I
HTE
DA
A
R
F
GIANGD
L
VRV
W
N
K
RG
Q
IL
TG
A
V
VT
DG
I
KK
GV
V
C
V
HE
GAW
P
D
L
E
-
-
-
N
G
L
CKN
GS
A
N
V
LTA
D
I
PS
SQ
LA
NACA
G
N
S
A
LV
Y
IEKYTGNAPKLTAFD
K
PAVQA
fig|566546.3.peg.4106
Escherichia coli W
MT
LT
RR
E
F
IK
H
S
G
I
AAG
AL
-
---
-
-
---
-
--
V
V
T
S
AAP
LP
AW
A
E
EK
-
--
G
G
K
I
LTA
G
RWG
A
MNVE
VKD
GK
I
-
---
V
S
STG
A
-
-
-
-
LAKTIPNS
L
QSTAADQVHTT
T
RI
Q
HP
MVRKSY
L
D
N
P
LQP
T
KG
RGE
DTYVQV
SW
EQ
AL
KL
I
HEQ
H
D
RI
R
K
A
N
G
PS
A
I
F
--
-
-
AG
SY
G
WR
S
S
G
V
LHK
A
QT
L
LQ
R
Y
MN
LA
GG
Y
S
GH
S
G
D
YST
GAAQ
V
I
MP
H
VV
GS
VEVYEQQTSW
P
L
IL
ENS
QV
VV
LW
G
M
NP
LN
T
LKIAWSSTDEQ
GL
E
Y
F-
-
H
QLK
KS
GK
P
V
I
A
IDP
IR
S
E
T
IEFF
G
DNAT
W
IAPNM
GTD
V
AL
ML
GIA
HT
L
M
T
QG
K
H
D
KV
FL
E
KY
T
I
GY
PQ
-----
-
--
-
-
-
-
FEE
Y
L
R
G
KS
-
D
N
T
P
K
SA
A
WAAEITG
V
P
EA
QI
V
KLA
-
E
LM
AA
NRTMLMA
GWG
I
QRQ
Q
Y
GEQ
K
H
WMLVT
L
AA
ML
G
QI
G
T
P
GG
GF
G
FSYHYSNGGNP
T
R
V
G
GV----
-
-
LP
E
M
S
AAIAG
Q
A
S
-
-
-
--
E
A
A
D
D
G
G-
M
R
AI
PVARIV
D
ALENPGGKYQHN
GKE
QTYPN
IK
M
IW
-
W
AG
GGN
F
TH
H
Q
D
T
N
R
LIK
A
W
Q
-
-
-
K
P
EMIVV
S
E
C
YW
TA
A
AK
H
ADI
V
LP
ITT
SF
E
RN
DL
T
MTGD
YS
N
Q
-
H
I
V
PM
KQ
A
VA
P
Q
FE
ARNDFD
V
FADL
A
EL
L
K
P
GGKE
I
Y
TEG
K
D
E
MA
WLKF
F
Y
DAAQKG
AR
AQ
R
V
T
MP
M
F
H
A
F
W
QQ
NK
L
IEMR
R
S
E
K
NE
Q
YV
R
Y
A
D
FR
A
DP
V
K
N
A
L
G
TPSGKIEIYS
KT
L
E
K
FGYKDCPAH
P
TW
--
-
---
-
L
A
P
--
-
-
---
-
D
E
W
K
G
T
A
D
E
K
-
Q
LQL
L
TA
H
PA
H
R
L
HS
Q
LNYA
E
L
R
K
K
YAV
A
D
R
EPIT
I
HTE
DA
A
R
F
GIANGD
L
VRV
W
N
K
RG
Q
IL
TG
A
V
VT
DG
I
KK
GV
V
C
V
HE
GAW
P
D
L
E
-
-
-
N
G
L
CKN
GS
A
N
V
LTA
D
I
PS
SQ
LA
NACA
G
N
S
A
LV
Y
IEKYTGNAPKLTAFD
K
PAVQA
fig|566546.4.peg.2039
Escherichia coli W
MT
LT
RR
E
F
IK
H
S
G
I
AAG
AL
-
---
-
-
---
-
--
V
V
T
S
AAP
LP
AW
A
E
EK
-
--
G
G
K
I
LTA
G
RWG
A
MNVE
VKD
GK
I
-
---
V
S
STG
A
-
-
-
-
LAKTIPNS
L
QSTAADQVHTT
T
RI
Q
HP
MVRKSY
L
D
N
P
LQP
T
KG
RGE
DTYVQV
SW
EQ
AL
KL
I
HEQ
H
D
RI
R
K
A
N
G
PS
A
I
F
--
-
-
AG
SY
G
WR
S
S
G
V
LHK
A
QT
L
LQ
R
Y
MN
LA
GG
Y
S
GH
S
G
D
YST
GAAQ
V
I
MP
H
VV
GS
VEVYEQQTSW
P
L
IL
ENS
QV
VV
LW
G
M
NP
LN
T
LKIAWSSTDEQ
GL
E
Y
F-
-
H
QLK
KS
GK
P
V
I
A
IDP
IR
S
E
T
IEFF
G
DNAT
W
IAPNM
GTD
V
AL
ML
GIA
HT
L
M
T
QG
K
H
D
KV
FL
E
KY
T
I
GY
PQ
-----
-
--
-
-
-
-
FEE
Y
L
R
G
KS
-
D
N
T
P
K
SA
A
WAAEITG
V
P
EA
QI
V
KLA
-
E
LM
AA
NRTMLMA
GWG
I
QRQ
Q
Y
GEQ
K
H
WMLVT
L
AA
ML
G
QI
G
T
P
GG
GF
G
FSYHYSNGGNP
T
R
V
G
GV----
-
-
LP
E
M
S
AAIAG
Q
A
S
-
-
-
--
E
A
A
D
D
G
G-
M
R
AI
PVARIV
D
ALENPGGKYQHN
GKE
QTYPN
IK
M
IW
-
W
AG
GGN
F
TH
H
Q
D
T
N
R
LIK
A
W
Q
-
-
-
K
P
EMIVV
S
E
C
YW
TA
A
AK
H
ADI
V
LP
ITT
SF
E
RN
DL
T
MTGD
YS
N
Q
-
H
I
V
PM
KQ
A
VA
P
Q
FE
ARNDFD
V
FADL
A
EL
L
K
P
GGKE
I
Y
TEG
K
D
E
MA
WLKF
F
Y
DAAQKG
AR
AQ
R
V
T
MP
M
F
H
A
F
W
QQ
NK
L
IEMR
R
S
E
K
NE
Q
YV
R
Y
A
D
FR
A
DP
V
K
N
A
L
G
TPSGKIEIYS
KT
L
E
K
FGYKDCPAH
P
TW
--
-
---
-
L
A
P
--
-
-
---
-
D
E
W
K
G
T
A
D
E
K
-
Q
LQL
L
TA
H
PA
H
R
L
HS
Q
LNYA
E
L
R
K
K
YAV
A
D
R
EPIT
I
HTE
DA
A
R
F
GIANGD
L
VRV
W
N
K
RG
Q
IL
TG
A
V
VT
DG
I
KK
GV
V
C
V
HE
GAW
P
D
L
E
-
-
-
N
G
L
CKN
GS
A
N
V
LTA
D
I
PS
SQ
LA
NACA
G
N
S
A
LV
Y
IEKYTGNAPKLTAFD
K
PAVQA
fig|199310.1.peg.2221
Escherichia coli CFT073 (7-815/815)
MT
LT
RR
E
F
IK
H
S
G
I
AAG
T
L
-
---
-
-
---
-
--
V
V
T
S
AAP
LP
AW
A
E
EK
-
--
G
G
K
I
LTA
G
RWG
A
MNVE
VKD
GK
I
-
---
V
S
STG
A
-
-
-
-
LAKTIPNS
L
QSTAADQVHTTA
RI
Q
HP
MVRKSY
L
D
N
P
LQP
V
KG
RGE
DTYVQV
SW
EQ
AL
KL
I
HEQ
H
D
RI
R
K
A
N
G
PS
A
I
F
--
-
-
AG
SY
G
WR
S
S
G
V
LHK
A
QT
L
LQ
R
Y
MN
LA
GG
Y
S
GH
S
G
D
YST
GAAQ
V
I
MP
H
VV
GS
VEVYEQQTSW
P
L
IL
ENS
QV
VV
LW
G
M
NP
LN
T
LKIAWSSTDEQ
GL
E
Y
F-
-
H
QLK
KS
GK
P
V
I
A
IDP
IR
S
E
T
IEFF
G
DNAT
W
IAPNM
GTD
V
AL
ML
GIA
HT
L
M
T
QG
K
H
D
KV
FL
E
KY
TT
GY
PQ
-----
-
--
-
-
-
-
FEE
Y
LT
G
KS
-
D
N
T
P
K
SA
A
WAAEITG
V
P
EA
QI
V
KLA
-
E
LM
AA
NRTMLMA
GWG
I
QRQ
Q
Y
GEQ
K
H
WMLVT
L
AA
ML
G
QI
G
T
P
GG
GF
G
FSYHYSNGGNP
T
R
V
G
GV----
-
-
LP
E
M
S
AAIAG
Q
A
S
-
-
-
--
E
A
A
D
D
G
G-
MTAI
PVARIV
D
ALENPGGKYQHN
GKE
QTYPN
IK
M
IW
-
W
AG
GGN
F
TH
H
Q
D
T
N
R
LIK
A
W
Q
-
-
-
K
P
EMIVV
S
E
C
YW
TA
A
AK
H
ADI
V
LP
ITT
SF
E
RN
DL
T
MTGD
YS
N
Q
-
H
I
V
LM
KQ
A
VA
P
Q
FE
ARNDFD
V
FADL
A
EL
L
K
P
GGKE
I
Y
TEG
K
D
E
MA
WLKF
F
Y
DAAQKG
AR
AQ
R
V
T
MP
M
F
N
A
F
W
QQ
NK
L
IEMR
R
S
E
K
NE
Q
Y
I
R
Y
G
D
FR
A
DP
V
K
N
A
L
G
TPSGKIEIYS
RT
L
E
K
FGYKDCPAH
P
TW
--
-
---
-
L
A
P
--
-
-
---
-
D
E
W
K
G
T
A
D
E
K
-
Q
LQL
L
TA
H
PA
H
R
L
HS
Q
LNYA
E
L
R
K
K
YAV
A
D
R
EPIT
I
HTE
DA
A
R
F
GIANGD
L
VRV
W
N
K
RG
Q
IL
TG
A
V
VT
DG
I
KK
GV
V
C
V
HE
GAW
P
D
L
E
-
-
-
N
G
L
CKN
GS
A
N
V
LTA
D
I
PS
SQ
LA
NACA
G
N
S
A
LV
Y
IEKYTGNA
L
KLTAFDQPAVQA
fig|199310.4.peg.2144
Escherichia coli CFT073
MT
LT
RR
E
F
IK
H
S
G
I
AAG
T
L
-
---
-
-
---
-
--
V
V
T
S
AAP
LP
AW
A
E
EK
-
--
G
G
K
I
LTA
G
RWG
A
MNVE
VKD
GK
I
-
---
V
S
STG
A
-
-
-
-
LAKTIPNS
L
QSTAADQVHTTA
RI
Q
HP
MVRKSY
L
D
N
P
LQP
V
KG
RGE
DTYVQV
SW
EQ
AL
KL
I
HEQ
H
D
RI
R
K
A
N
G
PS
A
I
F
--
-
-
AG
SY
G
WR
S
S
G
V
LHK
A
QT
L
LQ
R
Y
MN
LA
GG
Y
S
GH
S
G
D
YST
GAAQ
V
I
MP
H
VV
GS
VEVYEQQTSW
P
L
IL
ENS
QV
VV
LW
G
M
NP
LN
T
LKIAWSSTDEQ
GL
E
Y
F-
-
H
QLK
KS
GK
P
V
I
A
IDP
IR
S
E
T
IEFF
G
DNAT
W
IAPNM
GTD
V
AL
ML
GIA
HT
L
M
T
QG
K
H
D
KV
FL
E
KY
TT
GY
PQ
-----
-
--
-
-
-
-
FEE
Y
LT
G
KS
-
D
N
T
P
K
SA
A
WAAEITG
V
P
EA
QI
V
KLA
-
E
LM
AA
NRTMLMA
GWG
I
QRQ
Q
Y
GEQ
K
H
WMLVT
L
AA
ML
G
QI
G
T
P
GG
GF
G
FSYHYSNGGNP
T
R
V
G
GV----
-
-
LP
E
M
S
AAIAG
Q
A
S
-
-
-
--
E
A
A
D
D
G
G-
MTAI
PVARIV
D
ALENPGGKYQHN
GKE
QTYPN
IK
M
IW
-
W
AG
GGN
F
TH
H
Q
D
T
N
R
LIK
A
W
Q
-
-
-
K
P
EMIVV
S
E
C
YW
TA
A
AK
H
ADI
V
LP
ITT
SF
E
RN
DL
T
MTGD
YS
N
Q
-
H
I
V
LM
KQ
A
VA
P
Q
FE
ARNDFD
V
FADL
A
EL
L
K
P
GGKE
I
Y
TEG
K
D
E
MA
WLKF
F
Y
DAAQKG
AR
AQ
R
V
T
MP
M
F
N
A
F
W
QQ
NK
L
IEMR
R
S
E
K
NE
Q
Y
I
R
Y
G
D
FR
A
DP
V
K
N
A
L
G
TPSGKIEIYS
RT
L
E
K
FGYKDCPAH
P
TW
--
-
---
-
L
A
P
--
-
-
---
-
D
E
W
K
G
T
A
D
E
K
-
Q
LQL
L
TA
H
PA
H
R
L
HS
Q
LNYA
E
L
R
K
K
YAV
A
D
R
EPIT
I
HTE
DA
A
R
F
GIANGD
L
VRV
W
N
K
RG
Q
IL
TG
A
V
VT
DG
I
KK
GV
V
C
V
HE
GAW
P
D
L
E
-
-
-
N
G
L
CKN
GS
A
N
V
LTA
D
I
PS
SQ
LA
NACA
G
N
S
A
LV
Y
IEKYTGNA
L
KLTAFDQPAVQA
fig|749528.3.peg.4972
Escherichia coli MS 45-1
MT
LT
RR
E
F
IK
H
S
G
I
AAG
T
L
-
---
-
-
---
-
--
V
V
T
S
AAP
LP
AW
A
E
EK
-
--
G
G
K
I
LTA
G
RWG
A
MNVE
VKD
GK
I
-
---
V
S
STG
A
-
-
-
-
LAKTIPNS
L
QSTAADQVHTTA
RI
Q
HP
MVRKSY
L
D
N
P
LQP
V
KG
RGE
DTYVQV
SW
EQ
AL
KL
I
HEQ
H
D
RI
R
K
A
N
G
PS
A
I
F
--
-
-
AG
SY
G
WR
S
S
G
V
LHK
A
QT
L
LQ
R
Y
MN
LA
GG
Y
S
GH
S
G
D
YST
GAAQ
V
I
MP
H
VV
GS
VEVYEQQTSW
P
L
IL
ENS
QV
VV
LW
G
M
NP
LN
T
LKIAWSSTDEQ
GL
E
Y
F-
-
H
QLK
KS
GK
P
V
I
A
IDP
IR
S
E
T
IEFF
G
DNAT
W
IAPNM
GTD
V
AL
ML
GIA
HT
L
M
T
QG
K
H
D
KV
FL
E
KY
TT
GY
PQ
-----
-
--
-
-
-
-
FEE
Y
LT
G
KS
-
D
N
T
P
K
SA
A
WAAEITG
V
P
EA
QI
V
KLA
-
E
LM
AA
NRTMLMA
GWG
I
QRQ
Q
Y
GEQ
K
H
WMLVT
L
AA
ML
G
QI
G
T
P
GG
GF
G
FSYHYSNGGNP
T
R
V
G
GV----
-
-
LP
E
M
S
AAIAG
Q
A
S
-
-
-
--
E
A
A
D
D
G
G-
MTAI
PVARIV
D
ALENPGGKYQHN
GKE
QTYPN
IK
M
IW
-
W
AG
GGN
F
TH
H
Q
D
T
N
R
LIK
A
W
Q
-
-
-
K
P
EMIVV
S
E
C
YW
TA
A
AK
H
ADI
V
LP
ITT
SF
E
RN
DL
T
MTGD
YS
N
Q
-
H
I
V
LM
KQ
A
VA
P
Q
FE
ARNDFD
V
FADL
A
EL
L
K
P
GGKE
I
Y
TEG
K
D
E
MA
WLKF
F
Y
DAAQKG
AR
AQ
R
V
T
MP
M
F
N
A
F
W
QQ
NK
L
IEMR
R
S
E
K
NE
Q
Y
I
R
Y
G
D
FR
A
DP
V
K
N
A
L
G
TPSGKIEIYS
RT
L
E
K
FGYKDCPAH
P
TW
--
-
---
-
L
A
P
--
-
-
---
-
D
E
W
K
G
T
A
D
E
K
-
Q
LQL
L
TA
H
PA
H
R
L
HS
Q
LNYA
E
L
R
K
K
YAV
A
D
R
EPIT
I
HTE
DA
A
R
F
GIANGD
L
VRV
W
N
K
RG
Q
IL
TG
A
V
VT
DG
I
KK
GV
V
C
V
HE
GAW
P
D
L
E
-
-
-
N
G
L
CKN
GS
A
N
V
LTA
D
I
PS
SQ
LA
NACA
G
N
S
A
LV
Y
IEKYTGNA
L
KLTAFDQPAVQA
fig|714962.3.peg.2030
Escherichia coli IHE3034
MT
LT
RR
E
F
IK
H
S
G
I
AAG
T
L
-
---
-
-
---
-
--
V
V
T
S
AAP
LP
AW
A
E
EK
-
--
G
G
K
I
LTA
G
RWG
A
MNVE
VKD
GK
I
-
---
V
S
STG
A
-
-
-
-
LAKTIPNS
L
QSTAADQVHTTA
RI
Q
HP
MVRKSY
L
D
N
P
LQPAKG
RGE
DTYVQV
SW
EQ
AL
KL
I
HEQ
H
D
RI
R
K
A
N
G
PS
A
I
F
--
-
-
AG
SY
G
WR
S
S
G
V
LHK
A
QT
L
LQ
R
Y
MN
LA
GG
Y
S
GH
S
G
D
YST
GAAQ
V
I
MP
H
VV
GS
VEVYEQQTSW
P
L
IL
ENS
QV
VV
LW
G
M
NP
LN
T
LKIAWSSTDEQ
GL
E
Y
F-
-
H
QLK
KS
GK
P
V
I
A
IDP
I
C
S
E
T
IEFF
G
DNAT
W
IAPNM
GTD
V
AL
ML
GIA
HT
L
M
T
QG
K
H
D
KV
FL
E
KY
TT
GY
PQ
-----
-
--
-
-
-
-
FEE
Y
LT
G
KS
-
D
N
T
P
K
SA
A
WAAEITG
V
P
EA
QI
V
KLA
-
E
LM
AA
NRTMLMA
GWG
I
QRQ
Q
Y
GEQ
K
H
WMLVT
L
AA
ML
G
QI
G
T
P
GG
GF
G
FSYHYSNGGNP
T
R
V
G
GV----
-
-
LP
E
M
S
AAIAG
Q
A
S
-
-
-
--
E
A
A
D
D
G
G-
I
TAI
PVARIV
D
ALENPGGKYQHN
GKE
QTYPN
IK
M
IW
-
W
AG
GGN
F
TH
H
Q
D
T
N
R
LIK
A
W
Q
-
-
-
K
P
EMIVV
S
E
C
YW
TA
A
AK
H
ADI
V
LP
ITT
SF
E
RN
DL
T
MTGD
YS
N
Q
-
H
I
V
PM
KQ
A
VA
P
Q
FE
ARNDFD
V
FADL
A
EL
L
K
P
GGKE
I
Y
TEG
K
D
E
MA
WLKF
F
Y
DAAQKG
AR
AQ
R
V
T
MP
M
F
N
A
F
W
QQ
NK
L
IEMR
R
S
E
K
NE
Q
Y
I
R
Y
G
D
FR
A
DP
V
K
N
A
L
G
TPSGKIEIYS
RT
L
E
K
FGYKDCPAH
P
TW
--
-
---
-
L
A
P
--
-
-
---
-
D
E
W
K
G
T
A
D
E
K
-
Q
LQL
L
TA
H
PA
H
R
L
HS
Q
LNYA
E
L
R
K
K
YAV
A
D
R
EPIT
I
HTE
DA
A
R
F
GIANGD
L
VRV
W
N
K
RG
Q
IL
TG
A
V
VT
DG
I
KK
GV
V
C
V
HE
GAW
L
D
L
E
-
-
-
N
G
L
CKN
GS
A
N
V
LTA
D
I
PS
SQ
LA
NACA
G
NTA
LV
Y
IEKYTGNAPKLTAFDQPAVQA
fig|753642.3.peg.2475
Escherichia coli NC101
MT
LT
RR
E
F
IK
H
S
G
I
AAG
T
L
-
---
-
-
---
-
--
V
V
T
S
AAP
LP
AW
A
E
EK
-
--
G
G
K
I
LTA
G
RWG
A
MNVE
VKD
GK
I
-
---
V
S
STG
A
-
-
-
-
LAKTIPNS
L
QSTAADQVHTTA
RI
Q
HP
MVRKSY
L
D
N
P
LQPAKG
RGE
DTYVQV
SW
EQ
AL
KL
I
HEQ
H
D
RI
R
K
A
N
G
PS
A
I
F
--
-
-
AG
SY
G
WR
S
S
G
V
LHK
A
QT
L
LQ
R
Y
MN
LA
GG
Y
S
GH
S
G
D
YST
GAAQ
V
I
MP
H
VV
GS
VEVYEQQTSW
P
L
IL
ENS
QV
VV
LW
G
M
NP
LN
T
LKIAWSSTDEQ
GL
E
Y
F-
-
H
QLK
KS
GK
P
V
I
A
IDP
I
C
S
E
T
IEFF
G
DNAT
W
IAPNM
GTD
V
AL
ML
GIA
HT
L
M
T
QG
K
H
D
KV
FL
E
KY
TT
GY
PQ
-----
-
--
-
-
-
-
FEE
Y
LT
G
KS
-
D
N
T
P
K
SA
A
WAAEITG
V
P
EA
QI
V
KLA
-
E
LM
AA
NRTMLMA
GWG
I
QRQ
Q
Y
GEQ
K
H
WMLVT
L
AA
ML
G
QI
G
T
P
GG
GF
G
FSYHYSNGGNP
T
R
V
G
GV----
-
-
LP
E
M
S
AAIAG
Q
A
S
-
-
-
--
E
A
A
D
D
G
G-
I
TAI
PVARIV
D
ALENPGGKYQHN
GKE
QTYPN
IK
M
IW
-
W
AG
GGN
F
TH
H
Q
D
T
N
R
LIK
A
W
Q
-
-
-
K
P
EMIVV
S
E
C
YW
TA
A
AK
H
ADI
V
LP
ITT
SF
E
RN
DL
T
MTGD
YS
N
Q
-
H
I
V
PM
KQ
A
VA
P
Q
FE
ARNDFD
V
FADL
A
EL
L
K
P
GGKE
I
Y
TEG
K
D
E
MA
WLKF
F
Y
DAAQKG
AR
AQ
R
V
T
MP
M
F
N
A
F
W
QQ
NK
L
IEMR
R
S
E
K
NE
Q
Y
I
R
Y
G
D
FR
A
DP
V
K
N
A
L
G
TPSGKIEIYS
RT
L
E
K
FGYKDCPAH
P
TW
--
-
---
-
L
A
P
--
-
-
---
-
D
E
W
K
G
T
A
D
E
K
-
Q
LQL
L
TA
H
PA
H
R
L
HS
Q
LNYA
E
L
R
K
K
YAV
A
D
R
EPIT
I
HTE
DA
A
R
F
GIANGD
L
VRV
W
N
K
RG
Q
IL
TG
A
V
VT
DG
I
KK
GV
V
C
V
HE
GAW
L
D
L
E
-
-
-
N
G
L
CKN
GS
A
N
V
LTA
D
I
PS
SQ
LA
NACA
G
NTA
LV
Y
IEKYTGNAPKLTAFDQPAVQA
fig|585035.6.peg.1918
Escherichia coli S88
MT
LT
RR
E
F
IK
H
S
G
I
AAG
T
L
-
---
-
-
---
-
--
V
V
T
S
AAP
LP
AW
A
E
EK
-
--
G
G
K
I
LTA
G
RWG
A
MNVE
VKD
GK
I
-
---
V
S
STG
A
-
-
-
-
LAKTIPNS
L
QSTAADQVHTTA
RI
Q
HP
MVRKSY
L
D
N
P
LQPAKG
RGE
DTYVQV
SW
EQ
AL
KL
I
HEQ
H
D
RI
R
K
A
N
G
PS
A
I
F
--
-
-
AG
SY
G
WR
S
S
G
V
LHK
A
QT
L
LQ
R
Y
MN
LA
GG
Y
S
GH
S
G
D
YST
GAAQ
V
I
MP
H
VV
GS
VEVYEQQTSW
P
L
IL
ENS
QV
VV
LW
G
M
NP
LN
T
LKIAWSSTDEQ
GL
E
Y
F-
-
H
QLK
KS
GK
P
V
I
A
IDP
I
C
S
E
T
IEFF
G
DNAT
W
IAPNM
GTD
V
AL
ML
GIA
HT
L
M
T
QG
K
H
D
KV
FL
E
KY
TT
GY
PQ
-----
-
--
-
-
-
-
FEE
Y
LT
G
KS
-
D
N
T
P
K
SA
A
WAAEITG
V
P
EA
QI
V
KLA
-
E
LM
AA
NRTMLMA
GWG
I
QRQ
Q
Y
GEQ
K
H
WMLVT
L
AA
ML
G
QI
G
T
P
GG
GF
G
FSYHYSNGGNP
T
R
V
G
GV----
-
-
LP
E
M
S
AAIAG
Q
A
S
-
-
-
--
E
A
A
D
D
G
G-
I
TAI
PVARIV
D
ALENPGGKYQHN
GKE
QTYPN
IK
M
IW
-
W
AG
GGN
F
TH
H
Q
D
T
N
R
LIK
A
W
Q
-
-
-
K
P
EMIVV
S
E
C
YW
TA
A
AK
H
ADI
V
LP
ITT
SF
E
RN
DL
T
MTGD
YS
N
Q
-
H
I
V
PM
KQ
A
VA
P
Q
FE
ARNDFD
V
FADL
A
EL
L
K
P
GGKE
I
Y
TEG
K
D
E
MA
WLKF
F
Y
DAAQKG
AR
AQ
R
V
T
MP
M
F
N
A
F
W
QQ
NK
L
IEMR
R
S
E
K
NE
Q
Y
I
R
Y
G
D
FR
A
DP
V
K
N
A
L
G
TPSGKIEIYS
RT
L
E
K
FGYKDCPAH
P
TW
--
-
---
-
L
A
P
--
-
-
---
-
D
E
W
K
G
T
A
D
E
K
-
Q
LQL
L
TA
H
PA
H
R
L
HS
Q
LNYA
E
L
R
K
K
YAV
A
D
R
EPIT
I
HTE
DA
A
R
F
GIANGD
L
VRV
W
N
K
RG
Q
IL
TG
A
V
VT
DG
I
KK
GV
V
C
V
HE
GAW
L
D
L
E
-
-
-
N
G
L
CKN
GS
A
N
V
LTA
D
I
PS
SQ
LA
NACA
G
NTA
LV
Y
IEKYTGNAPKLTAFDQPAVQA
fig|869729.3.peg.1653
Escherichia coli UM146
MT
LT
RR
E
F
IK
H
S
G
I
AAG
T
L
-
---
-
-
---
-
--
V
V
T
S
AAP
LP
AW
A
E
EK
-
--
G
G
K
I
LTA
G
RWG
A
MNVE
VKD
GK
I
-
---
V
S
STG
A
-
-
-
-
LAKTIPNS
L
QSTAADQVHTTA
RI
Q
HP
MVRKSY
L
D
N
P
LQPAKG
RGE
DTYVQV
SW
EQ
AL
KL
I
HEQ
H
D
RI
R
K
A
N
G
PS
A
I
F
--
-
-
AG
SY
G
WR
S
S
G
V
LHK
A
QT
L
LQ
R
Y
MN
LA
GG
Y
S
GH
S
G
D
YST
GAAQ
V
I
MP
H
VV
GS
VEVYEQQTSW
P
L
IL
ENS
QV
VV
LW
G
M
NP
LN
T
LKIAWSSTDEQ
GL
E
Y
F-
-
H
QLK
KS
GK
P
V
I
A
IDP
I
C
S
E
T
IEFF
G
DNAT
W
IAPNM
GTD
V
AL
ML
GIA
HT
L
M
T
QG
K
H
D
KV
FL
E
KY
TT
GY
PQ
-----
-
--
-
-
-
-
FEE
Y
LT
G
KS
-
D
N
T
P
K
SA
A
WAAEITG
V
P
EA
QI
V
KLA
-
E
LM
AA
NRTMLMA
GWG
I
QRQ
Q
Y
GEQ
K
H
WMLVT
L
AA
ML
G
QI
G
T
P
GG
GF
G
FSYHYSNGGNP
T
R
V
G
GV----
-
-
LP
E
M
S
AAIAG
Q
A
S
-
-
-
--
E
A
A
D
D
G
G-
I
TAI
PVARIV
D
ALENPGGKYQHN
GKE
QTYPN
IK
M
IW
-
W
AG
GGN
F
TH
H
Q
D
T
N
R
LIK
A
W
Q
-
-
-
K
P
EMIVV
S
E
C
YW
TA
A
AK
H
ADI
V
LP
ITT
SF
E
RN
DL
T
MTGD
YS
N
Q
-
H
I
V
PM
KQ
A
VA
P
Q
FE
ARNDFD
V
FADL
A
EL
L
K
P
GGKE
I
Y
TEG
K
D
E
MA
WLKF
F
Y
DAAQKG
AR
AQ
R
V
T
MP
M
F
N
A
F
W
QQ
NK
L
IEMR
R
S
E
K
NE
Q
Y
I
R
Y
G
D
FR
A
DP
V
K
N
A
L
G
TPSGKIEIYS
RT
L
E
K
FGYKDCPAH
P
TW
--
-
---
-
L
A
P
--
-
-
---
-
D
E
W
K
G
T
A
D
E
K
-
Q
LQL
L
TA
H
PA
H
R
L
HS
Q
LNYA
E
L
R
K
K
YAV
A
D
R
EPIT
I
HTE
DA
A
R
F
GIANGD
L
VRV
W
N
K
RG
Q
IL
TG
A
V
VT
DG
I
KK
GV
V
C
V
HE
GAW
L
D
L
E
-
-
-
N
G
L
CKN
GS
A
N
V
LTA
D
I
PS
SQ
LA
NACA
G
NTA
LV
Y
IEKYTGNAPKLTAFDQPAVQA
fig|364106.7.peg.2109
Escherichia coli UTI89
MT
LT
RR
E
F
IK
H
S
G
I
AAG
T
L
-
---
-
-
---
-
--
V
V
T
S
AAP
LP
AW
A
E
EK
-
--
G
G
K
I
LTA
G
RWG
A
MNVE
VKD
GK
I
-
---
V
S
STG
A
-
-
-
-
LAKTIPNS
L
QSTAADQVHTTA
RI
Q
HP
MVRKSY
L
D
N
P
LQPAKG
RGE
DTYVQV
SW
EQ
AL
KL
I
HEQ
H
D
RI
R
K
A
N
G
PS
A
I
F
--
-
-
AG
SY
G
WR
S
S
G
V
LHK
A
QT
L
LQ
R
Y
MN
LA
GG
Y
S
GH
S
G
D
YST
GAAQ
V
I
MP
H
VV
GS
VEVYEQQTSW
P
L
IL
ENS
QV
VV
LW
G
M
NP
LN
T
LKIAWSSTDEQ
GL
E
Y
F-
-
H
QLK
KS
GK
P
V
I
A
IDP
I
C
S
E
T
IEFF
G
DNAT
W
IAPNM
GTD
V
AL
ML
GIA
HT
L
M
T
QG
K
H
D
KV
FL
E
KY
TT
GY
PQ
-----
-
--
-
-
-
-
FEE
Y
LT
G
KS
-
D
N
T
P
K
SA
A
WAAEITG
V
P
EA
QI
V
KLA
-
E
LM
AA
NRTMLMA
GWG
I
QRQ
Q
Y
GEQ
K
H
WMLVT
L
AA
ML
G
QI
G
T
P
GG
GF
G
FSYHYSNGGNP
T
R
V
G
GV----
-
-
LP
E
M
S
AAIAG
Q
A
S
-
-
-
--
E
A
A
D
D
G
G-
I
TAI
PVARIV
D
ALENPGGKYQHN
GKE
QTYPN
IK
M
IW
-
W
AG
GGN
F
TH
H
Q
D
T
N
R
LIK
A
W
Q
-
-
-
K
P
EMIVV
S
E
C
YW
TA
A
AK
H
ADI
V
LP
ITT
SF
E
RN
DL
T
MTGD
YS
N
Q
-
H
I
V
PM
KQ
A
VA
P
Q
FE
ARNDFD
V
FADL
A
EL
L
K
P
GGKE
I
Y
TEG
K
D
E
MA
WLKF
F
Y
DAAQKG
AR
AQ
R
V
T
MP
M
F
N
A
F
W
QQ
NK
L
IEMR
R
S
E
K
NE
Q
Y
I
R
Y
G
D
FR
A
DP
V
K
N
A
L
G
TPSGKIEIYS
RT
L
E
K
FGYKDCPAH
P
TW
--
-
---
-
L
A
P
--
-
-
---
-
D
E
W
K
G
T
A
D
E
K
-
Q
LQL
L
TA
H
PA
H
R
L
HS
Q
LNYA
E
L
R
K
K
YAV
A
D
R
EPIT
I
HTE
DA
A
R
F
GIANGD
L
VRV
W
N
K
RG
Q
IL
TG
A
V
VT
DG
I
KK
GV
V
C
V
HE
GAW
L
D
L
E
-
-
-
N
G
L
CKN
GS
A
N
V
LTA
D
I
PS
SQ
LA
NACA
G
NTA
LV
Y
IEKYTGNAPKLTAFDQPAVQA
fig|364106.8.peg.2112
Escherichia coli UTI89
MT
LT
RR
E
F
IK
H
S
G
I
AAG
T
L
-
---
-
-
---
-
--
V
V
T
S
AAP
LP
AW
A
E
EK
-
--
G
G
K
I
LTA
G
RWG
A
MNVE
VKD
GK
I
-
---
V
S
STG
A
-
-
-
-
LAKTIPNS
L
QSTAADQVHTTA
RI
Q
HP
MVRKSY
L
D
N
P
LQPAKG
RGE
DTYVQV
SW
EQ
AL
KL
I
HEQ
H
D
RI
R
K
A
N
G
PS
A
I
F
--
-
-
AG
SY
G
WR
S
S
G
V
LHK
A
QT
L
LQ
R
Y
MN
LA
GG
Y
S
GH
S
G
D
YST
GAAQ
V
I
MP
H
VV
GS
VEVYEQQTSW
P
L
IL
ENS
QV
VV
LW
G
M
NP
LN
T
LKIAWSSTDEQ
GL
E
Y
F-
-
H
QLK
KS
GK
P
V
I
A
IDP
I
C
S
E
T
IEFF
G
DNAT
W
IAPNM
GTD
V
AL
ML
GIA
HT
L
M
T
QG
K
H
D
KV
FL
E
KY
TT
GY
PQ
-----
-
--
-
-
-
-
FEE
Y
LT
G
KS
-
D
N
T
P
K
SA
A
WAAEITG
V
P
EA
QI
V
KLA
-
E
LM
AA
NRTMLMA
GWG
I
QRQ
Q
Y
GEQ
K
H
WMLVT
L
AA
ML
G
QI
G
T
P
GG
GF
G
FSYHYSNGGNP
T
R
V
G
GV----
-
-
LP
E
M
S
AAIAG
Q
A
S
-
-
-
--
E
A
A
D
D
G
G-
I
TAI
PVARIV
D
ALENPGGKYQHN
GKE
QTYPN
IK
M
IW
-
W
AG
GGN
F
TH
H
Q
D
T
N
R
LIK
A
W
Q
-
-
-
K
P
EMIVV
S
E
C
YW
TA
A
AK
H
ADI
V
LP
ITT
SF
E
RN
DL
T
MTGD
YS
N
Q
-
H
I
V
PM
KQ
A
VA
P
Q
FE
ARNDFD
V
FADL
A
EL
L
K
P
GGKE
I
Y
TEG
K
D
E
MA
WLKF
F
Y
DAAQKG
AR
AQ
R
V
T
MP
M
F
N
A
F
W
QQ
NK
L
IEMR
R
S
E
K
NE
Q
Y
I
R
Y
G
D
FR
A
DP
V
K
N
A
L
G
TPSGKIEIYS
RT
L
E
K
FGYKDCPAH
P
TW
--
-
---
-
L
A
P
--
-
-
---
-
D
E
W
K
G
T
A
D
E
K
-
Q
LQL
L
TA
H
PA
H
R
L
HS
Q
LNYA
E
L
R
K
K
YAV
A
D
R
EPIT
I
HTE
DA
A
R
F
GIANGD
L
VRV
W
N
K
RG
Q
IL
TG
A
V
VT
DG
I
KK
GV
V
C
V
HE
GAW
L
D
L
E
-
-
-
N
G
L
CKN
GS
A
N
V
LTA
D
I
PS
SQ
LA
NACA
G
NTA
LV
Y
IEKYTGNAPKLTAFDQPAVQA
fig|562.376.peg.2230
Escherichia coli WV_060327
MT
LT
RR
E
F
IK
H
S
G
I
AAG
T
L
-
---
-
-
---
-
--
V
V
T
S
AAP
LP
AW
A
E
EK
-
--
G
G
K
I
LTA
G
RWG
A
MNVE
VKD
GK
I
-
---
V
S
STG
A
-
-
-
-
LAKTIPNS
L
QSTAADQVHTTA
RI
Q
HP
MVRKSY
L
D
N
P
LQP
V
KG
RGE
DTYVQV
SW
EQ
AL
KL
I
HEQ
H
D
RI
R
K
A
N
G
PS
A
I
F
--
-
-
AG
SY
G
WR
S
S
G
V
LHK
A
QT
L
LQ
R
Y
MN
LA
GG
Y
S
GH
S
G
D
YST
GAAQ
V
I
MP
H
VV
GS
VEVYEQQTSW
P
L
IL
ENS
QV
VV
LW
G
M
NP
LN
T
LKIAWSSTDEQ
GL
E
Y
F-
-
H
QLK
KS
GK
P
V
I
A
IDP
IR
S
E
T
IEFF
G
DNAT
W
IAPNM
GTD
V
AL
ML
GIA
HT
L
M
T
QG
K
H
D
KV
FL
E
KY
TT
GY
PQ
-----
-
--
-
-
-
-
FEE
Y
LT
G
KS
-
D
N
T
P
K
SA
A
WAAEITG
V
P
EA
QI
V
KLA
-
E
LM
AA
NRTMLMA
GWG
I
QRQ
Q
Y
GEQ
K
H
WMLVT
L
AA
ML
G
QI
G
T
P
GG
GF
G
FSYHYSNGGNP
T
R
V
G
GV----
-
-
LP
E
M
S
AAIAG
Q
A
S
-
-
-
--
E
A
A
D
D
G
G-
MTAI
PVARIV
D
ALENPGGKYQHN
GKE
QTYPN
IK
M
IW
-
W
AG
GGN
F
TH
H
Q
D
T
N
R
LIK
A
W
Q
-
-
-
K
P
EMIVV
S
E
C
YW
TA
A
AK
H
ADI
V
LP
ITT
SF
E
RN
DL
T
MTGD
YS
N
Q
-
H
I
V
PM
KQ
A
VA
P
Q
FE
ARNDFD
V
FADL
A
EL
L
K
P
GGKE
I
Y
TEG
K
D
E
MA
WLKF
F
Y
DAAQKG
AR
AQ
R
V
T
MP
M
F
N
A
F
W
QQ
NK
L
IEMR
R
S
E
K
NE
Q
Y
I
R
Y
G
D
FR
A
DP
V
K
N
A
L
G
TPSGKIEIYS
RT
L
E
K
FGYKDCPAH
P
TW
--
-
---
-
L
A
P
--
-
-
---
-
D
E
W
K
G
T
A
D
E
K
-
Q
LQL
L
TA
H
PA
H
R
L
HS
Q
LNYA
E
L
R
K
K
YAV
A
D
R
EPIT
I
HTE
DA
A
R
F
GIANGD
L
VRV
W
N
K
RG
Q
IL
TG
A
V
VT
DG
I
KK
GV
V
C
V
HE
GAW
P
D
L
E
-
-
-
N
G
L
CKN
GS
A
N
V
LTA
D
I
S
S
SQ
LA
NACA
G
N
S
A
LV
Y
IEKYTGNA
L
KLTAFDQP
T
VQA
fig|749531.3.peg.623
Escherichia coli MS 69-1
MT
LT
RR
E
F
IK
H
S
G
I
AAG
AL
-
---
-
-
---
-
--
V
V
T
S
AAP
LP
AW
A
E
EK
-
--
G
G
K
I
LTA
G
RWG
A
MNVE
V
E
D
GK
I
-
---
V
S
STG
A
-
-
-
-
LAKTIPNS
L
QSTAADQVHTT
V
RI
Q
HP
MVRKSY
L
D
N
P
LQPAKG
RGE
D
I
YVQV
SW
EQ
AL
KL
I
HEQ
H
D
RI
R
K
A
N
G
PS
A
I
F
--
-
-
AG
SY
G
WR
S
S
G
V
LHK
A
QT
L
LQ
R
Y
MN
LA
GG
Y
S
GH
S
G
D
YST
GAAQ
V
I
MP
H
VV
GS
VEVYEQQTSW
P
L
IL
ENS
QV
VV
LW
G
M
NP
LN
T
LKIAWSSTDEQ
GL
E
Y
F-
-
H
QLK
KS
GK
P
V
I
A
IDP
IR
S
E
T
IEFF
G
DNAT
W
IAPNM
GTD
V
AL
ML
GIA
HT
L
M
V
QG
K
H
D
K
A
FL
E
KY
TT
GY
PQ
-----
-
--
-
-
-
-
FEE
Y
L
A
G
KS
-
D
N
T
P
K
SA
A
WAAEI
S
G
V
P
EA
QIIKLA
-
E
LM
AA
NRTMLMA
GWG
I
QRQ
Q
Y
GEQ
K
H
WMLVT
L
AA
ML
G
QI
G
T
P
GG
GF
G
FSYHYSNGGNP
T
R
V
G
GV----
-
-
LP
E
M
S
AAIAG
Q
A
S
-
-
-
--
E
A
A
D
D
G
G-
MTAI
PVARIV
D
ALENPGGKYQHN
GKE
QTYPN
IK
M
IW
-
W
AG
GGN
F
TH
H
Q
D
T
N
R
LIK
A
W
Q
-
-
-
K
P
EMIVV
S
E
C
YW
TA
A
AK
H
ADI
V
LP
ITT
SF
E
RN
DL
T
MTGD
YS
N
Q
-
H
I
V
PM
KQ
A
VA
P
Q
FE
ARNDFD
V
FADL
A
EL
L
K
P
GGKE
I
Y
TEGR
D
E
MA
WLKF
F
Y
DAAQKG
AR
AQ
R
V
T
MP
M
F
N
A
F
W
QQ
NK
L
IEMR
R
S
E
K
NE
Q
YV
R
Y
A
D
FR
A
DP
V
K
N
A
L
G
TPSGKIEIYS
KT
L
E
K
FGYKDCPAH
P
TW
--
-
---
-
L
A
P
--
-
-
---
-
D
E
W
K
G
S
A
D
E
K
-
Q
LQL
L
TA
H
PA
H
R
L
HS
Q
LNYA
E
L
R
K
K
YAV
A
D
R
EPIT
I
HTE
DA
A
R
F
GIANGD
L
VRV
W
N
R
RG
Q
IL
TG
A
V
VT
DG
I
KK
GV
V
C
V
HE
GAW
P
D
L
E
-
-
-
N
G
L
CKN
GS
A
N
V
LTA
D
I
PS
SQ
LA
NACA
G
N
S
A
LV
Y
IEKYTGNAPKLTAFDQPAVQA
fig|685038.3.peg.1892
Escherichia coli O83:H1 str. NRG 857C
MT
LT
RR
E
F
IK
H
S
G
I
AAG
T
L
-
---
-
-
---
-
--
V
V
T
S
AAP
LP
AW
A
E
EK
-
--
G
G
K
I
LTA
G
RWG
A
MNVE
VKD
GK
I
-
---
V
S
STG
A
-
-
-
-
LAKTIPNS
L
QSTAADQVHTTA
RI
Q
HP
MVRKSY
L
D
N
P
LQP
V
KG
RGE
DTYVQV
SW
EQ
AL
KL
I
HEQ
H
D
RI
R
K
A
N
G
PS
A
I
F
--
-
-
AG
SY
G
WR
S
S
G
V
LHK
A
QT
L
LQ
R
Y
MN
LA
GG
Y
S
GH
S
G
D
YST
GAAQ
V
I
MP
H
VV
GS
VEVYEQQTSW
P
L
IL
ENS
QV
VV
LW
G
M
NP
LN
T
LKIAWSSTDEQ
GL
E
Y
F-
-
H
QLK
KS
GK
P
V
I
A
IDP
I
C
S
E
T
IEFF
G
DNAT
W
IAPNM
GTD
V
AL
ML
GIA
HT
L
M
T
QG
K
H
D
KV
FL
E
KY
TT
GY
PQ
-----
-
--
-
-
-
-
FEE
Y
LT
G
KS
-
D
N
T
P
K
SA
A
WAAEITG
V
P
EA
QI
V
KLA
-
E
LM
AA
NRTMLMA
GWG
I
QRQ
Q
Y
GEQ
K
H
WMLVT
L
AA
ML
G
QI
G
T
P
GG
GF
G
FSYHYSNGGNP
T
R
V
G
GV----
-
-
LP
E
M
S
AAIAG
Q
A
S
-
-
-
--
E
A
A
D
D
G
G-
MTAI
PVARIV
D
ALENPGGKYQHN
GKE
QTYPN
IK
M
IW
-
W
AG
GGN
F
TH
H
Q
D
T
N
R
LIK
A
W
Q
-
-
-
K
P
EMIVV
S
E
C
YW
TA
A
AK
H
ADI
V
LP
ITT
SF
E
RN
DL
T
MTGD
YS
N
Q
-
H
I
V
PM
KQ
A
VA
A
Q
FE
ARNDFD
V
FADL
A
EL
L
K
P
GGKE
I
Y
TEG
K
D
E
MA
WLKF
F
Y
DAAQKG
AR
AQ
R
V
T
MP
M
F
N
A
F
W
QQ
NK
L
IEMR
R
S
E
K
NE
Q
Y
I
R
Y
G
D
FR
A
DP
V
K
N
A
L
G
TPSGKIEIYS
KT
L
E
K
FGYKDCPAH
P
TW
--
-
---
-
L
A
P
--
-
-
---
-
D
E
W
K
G
T
A
D
E
K
-
Q
LQL
L
TA
H
PA
H
R
L
HS
Q
LNYA
E
L
R
K
K
YAV
A
D
R
EPIT
I
HTE
DA
A
R
F
GIANGD
L
VRV
W
N
K
RG
Q
IL
TG
A
V
VT
DG
I
KK
GV
V
C
V
HE
GAW
P
D
L
E
-
-
-
N
G
L
CKN
GS
A
N
V
LTA
D
I
PS
SQ
LA
NACA
G
N
S
A
LV
Y
IEKYTGNA
L
KLTAFDQPAVQA
fig|679207.4.peg.4773
Escherichia coli MS 107-1
MT
LT
RR
E
F
IK
H
S
G
I
AAG
AL
-
---
-
-
---
-
--
V
V
T
S
AAP
LP
AW
A
E
EK
-
--
G
G
K
I
LTA
G
RWG
A
MNVE
VKD
GK
I
-
---
V
S
STG
A
-
-
-
-
LAKTIPNS
L
QSTAADQVHTT
T
RI
Q
HP
MVRKSY
L
D
N
P
LQP
T
KG
RGE
DTYVQV
SW
EQ
AL
KL
I
HEQ
H
D
RI
R
K
A
N
G
PS
A
I
F
--
-
-
AG
SY
G
WR
S
S
G
V
LHK
A
QT
L
LQ
R
Y
MN
LA
GG
Y
S
GH
S
G
D
YST
GAAQ
V
I
MP
H
VV
GS
VEVYEQQTSW
P
L
IL
ENS
QV
VV
LW
G
M
NP
LN
T
LKIAWSSTDEQ
GL
E
Y
F-
-
H
QLK
KS
GK
P
V
I
A
IDP
IR
S
E
T
I
D
FF
G
DNAT
W
IAPNM
GTD
V
AL
ML
GIA
HT
L
M
T
QG
K
H
D
KV
FL
E
KY
TT
GY
PQ
-----
-
--
-
-
-
-
FEE
Y
L
R
G
KS
-
D
N
T
P
K
SA
A
WAAEITG
V
P
EA
QI
V
KLA
-
E
LM
AA
NRTMLMA
GWG
I
QRQ
Q
Y
GEQ
K
H
WMLVT
L
AA
ML
G
QI
G
T
P
GG
GF
G
FSYHYSNGGNP
T
R
V
G
GV----
-
-
LP
E
M
S
AAIAG
Q
A
S
-
-
-
--
E
A
A
D
D
G
G-
M
R
AI
PVARIV
D
ALENPGGKYQHN
GKE
QTYPN
IK
M
IW
-
W
AG
GGN
F
TH
H
Q
D
T
N
R
LIK
A
W
Q
-
-
-
K
P
EMIVV
S
E
C
YW
TA
A
AK
H
ADI
V
LP
ITT
SF
E
RN
DL
T
MTGD
YS
N
Q
-
H
I
V
PM
KQ
A
VA
P
Q
FE
ARNDFD
V
FADL
A
EL
L
K
P
GGKE
I
Y
TEG
K
D
E
MA
WLKF
F
Y
DAAQKG
AR
AQ
R
V
T
MP
M
F
N
V
F
W
QQ
NK
L
IEMR
R
S
E
K
NE
Q
YV
R
Y
G
D
FR
A
DP
V
K
N
A
L
G
TPSGKIEIYS
KT
L
E
K
FGYKDCPAH
P
TW
--
-
---
-
L
A
P
--
-
-
---
-
D
E
W
K
G
T
A
D
E
K
-
Q
LQL
L
TA
H
PA
H
R
L
HS
Q
LNYA
G
L
R
K
K
YAV
A
D
R
EPIT
I
HTE
DA
A
R
F
GIANGD
L
VRV
W
N
K
RG
Q
IL
TG
A
V
VT
DG
I
KK
GV
V
C
V
HE
GAW
P
D
L
E
-
-
-
N
G
L
CKN
GS
A
N
V
LTA
D
I
PS
SQ
LA
NACA
G
N
S
A
LV
Y
IEKYTGNAPKLTAFD
K
PAVQA
fig|216593.1.peg.707
Escherichia coli E2348/69 (7-815/815)
MT
LT
RR
E
F
IK
H
S
G
I
AAG
T
L
-
---
-
-
---
-
--
V
V
T
S
AAP
LP
AW
A
E
EK
-
--
G
G
K
I
LTA
G
RWG
A
MNVE
VKD
GK
I
-
---
V
S
STG
A
-
-
-
-
LAKTIPNS
L
QSTAADQVHTTA
RI
Q
HP
MVRKSY
L
D
N
P
LQPAKG
RGE
DTYVQV
SW
EQ
AL
KL
I
HEQ
H
D
RI
R
K
A
N
G
PS
A
I
F
--
-
-
AG
SY
G
WR
S
S
G
V
LHK
A
QT
L
LQ
R
Y
MN
LA
GG
Y
S
GH
S
G
D
YST
GAAQ
V
I
MP
H
VV
GS
VEVYEQQTSW
P
L
IL
ENS
QV
VV
LW
G
M
NP
LN
T
LKIAWSSTDEQ
GL
E
Y
F-
-
H
QLK
KS
GK
P
V
I
A
IDP
IR
S
E
T
IEFF
G
DNAT
W
IAPNM
GTD
V
AL
ML
GIA
HT
L
M
T
QG
K
H
D
KV
FL
E
KY
TT
GY
PQ
-----
-
--
-
-
-
-
FEE
Y
LT
G
KS
-
D
N
T
P
K
SA
A
WAAEITG
V
P
EA
QI
V
KLA
-
E
LM
AA
NRTMLMA
GWG
I
QRQ
Q
Y
GEQ
K
H
WMLVT
L
AA
ML
G
QI
G
T
P
GG
GF
G
FSYHYSNGGNP
T
R
V
G
GV----
-
-
LP
E
M
S
AAIAG
Q
A
S
-
-
-
--
E
A
A
D
D
G
G-
MTAI
PVARIV
D
ALENPGGKYQHN
GKE
QTYPN
IK
M
IW
-
W
AG
GGN
F
TH
H
Q
D
T
N
R
LIK
A
R
Q
-
-
-
K
P
EMIVV
S
E
C
YW
TA
A
AK
H
ADI
V
LP
ITT
SF
E
RN
DL
T
MTGD
YS
N
Q
-
H
I
V
PM
KQ
A
VA
A
Q
FE
ARNDFD
V
FADL
A
EL
L
K
P
GGKE
I
Y
TEG
K
D
E
MA
WLKF
F
Y
DAAQKG
AR
AQ
R
V
T
MP
M
F
N
A
F
W
QQ
NK
L
IEMR
R
S
E
K
NE
Q
Y
I
R
Y
G
D
FR
A
DP
V
K
N
A
L
G
TPSGKIEIYS
RT
L
E
K
FGYKDCPAH
P
T
R
--
-
---
-
L
A
P
--
-
-
---
-
D
E
W
K
G
T
A
D
E
K
-
Q
LQL
L
TA
H
PA
H
R
L
HS
Q
LNYA
E
L
R
K
K
YAV
A
D
R
EPIT
I
HTE
DA
A
R
F
GIANGD
L
VRV
W
N
K
RG
Q
IL
TG
A
V
VT
DG
I
KK
GV
V
C
V
HE
GAW
P
D
L
E
-
-
-
N
G
L
CKN
GS
A
N
V
LTA
D
I
PS
SQ
LA
NACA
G
N
S
A
LV
Y
IEKYTGNAPKLTAFDQPA
I
QA
fig|656437.3.peg.2122
Escherichia coli TA143
MT
LT
RR
E
F
IK
H
S
G
I
AAG
AL
-
---
-
-
---
-
--
V
V
T
S
AAP
LP
AW
A
E
EK
-
--
G
G
K
I
LTA
G
RWG
A
MNVE
V
E
D
GK
I
-
---
V
S
STG
A
-
-
-
-
LAKTIPNS
L
QSTAADQVHTTA
RI
Q
HP
MVRKSY
L
D
N
P
LQPAKG
RGE
D
I
YVQV
SW
EQ
AL
KL
I
HEQ
H
D
RI
R
K
A
N
G
PS
A
I
F
--
-
-
AG
SY
G
WR
S
S
G
V
LHK
A
QT
L
LQ
R
Y
MN
LA
GG
Y
S
GH
S
G
D
YST
GAAQ
V
I
MP
H
VV
GS
VEVYEQQTSW
P
L
IL
ENS
QV
VV
LW
G
M
NP
LN
T
LKIAWSSTDEQ
GL
E
Y
F-
-
H
QLK
KS
GK
P
V
I
A
IDP
IR
S
E
T
IEFF
G
DNAT
W
IAPNM
GTD
V
AL
ML
GIA
HT
L
M
V
QG
K
H
D
K
A
FL
E
KY
TT
GY
PQ
-----
-
--
-
-
-
-
FEE
Y
L
A
G
KS
-
D
N
T
P
K
SA
A
WAAEI
S
G
V
P
EA
QIIKLA
-
E
LM
AA
NRTMLMA
GWG
I
QRQ
Q
Y
GEQ
K
H
WMLVT
L
AA
ML
G
QI
G
T
P
GG
GF
G
FSYHYSNGGNP
T
R
V
G
GV----
-
-
LP
E
M
S
AAIAG
Q
A
S
-
-
-
--
E
A
A
D
D
G
G-
MTAI
PVARIV
D
ALENPGGKYQHN
GKE
QTYPN
IK
M
IW
-
W
AG
GGN
F
TH
H
Q
D
T
N
R
LIK
A
W
Q
-
-
-
K
P
EMIVV
S
E
C
YW
TA
A
AK
H
ADI
V
LP
ITT
SF
E
RN
DL
T
MTGD
YS
N
Q
-
H
I
V
PM
KQ
A
VA
A
Q
FE
ARNDFD
V
FADL
A
EL
L
K
P
GGKE
I
Y
TEGR
D
E
MA
WLKF
F
Y
DAAQKG
AR
AQ
R
V
T
MP
M
F
N
A
F
W
QQ
NK
L
IEMR
R
S
E
K
NE
Q
YV
R
Y
G
D
FR
A
DP
V
K
N
A
L
G
TPSGKIEIYS
KT
L
E
K
FGYKDCPAH
P
TW
--
-
---
-
L
A
P
--
-
-
---
-
D
E
W
K
G
S
A
D
D
K
-
Q
LQL
L
TA
H
PA
H
R
L
HS
Q
LNYA
E
L
R
K
K
YAV
A
D
R
EPIT
I
HTE
DA
A
R
F
GIANGD
L
VRV
W
N
K
RG
Q
IL
TG
A
V
VT
DG
I
KK
GV
V
C
V
HE
GAW
P
D
L
E
-
-
-
N
G
L
CKN
GS
A
N
V
LTA
D
I
PS
SQ
LA
NACA
G
N
S
A
LV
Y
IEKYT
S
NAPKLTAFDQPAVQA
fig|340197.3.peg.3114
Escherichia coli F11
MT
LT
RR
E
F
IK
H
S
G
I
AAG
T
L
-
---
-
-
---
-
--
V
V
T
S
AAP
LP
AW
A
E
EK
-
--
G
G
K
I
LTA
G
RWG
A
MNVE
VKD
GK
I
-
---
V
S
STG
A
-
-
-
-
LAKTIPNS
L
QSTAADQVHTTA
RI
Q
HP
MVRKSY
L
D
N
P
LQP
V
KG
RGE
DTYVQV
SW
EQ
AL
KL
I
HEQ
H
D
RI
R
K
A
N
G
PS
A
I
F
--
-
-
AG
SY
G
WR
S
S
G
V
LHK
A
QT
L
LQ
R
Y
MN
LA
GG
Y
S
GH
S
G
D
YST
GAAQ
V
I
MP
H
VV
GS
VEVYEQQTSW
P
L
IL
ENS
QV
VV
LW
G
M
NP
LN
T
LKIAWSSTDEQ
GL
E
Y
F-
-
H
QLK
KS
GK
P
V
I
A
IDP
I
C
S
E
T
IEFF
G
DNAT
W
IAPNM
GTD
V
AL
ML
GIA
HT
L
M
T
QG
K
H
D
KV
FL
E
KY
TT
GY
PQ
-----
-
--
-
-
-
-
FEE
Y
LT
G
KS
-
D
N
T
P
K
SA
A
WAAEITG
V
P
EA
QI
V
KLA
-
E
LM
AA
NRTMLMA
GWG
I
QRQ
Q
Y
GEQ
K
H
WMLVT
L
AA
ML
G
QI
G
T
P
GG
GF
G
FSYHYSNGGNP
T
R
V
G
GV----
-
-
LP
E
M
S
AAIAG
Q
A
S
-
-
-
--
E
A
A
D
D
G
G-
MTAI
PVARIV
D
ALENPGGKYQHN
GKE
QTYPN
IK
M
IW
-
W
AG
GGN
F
TH
H
Q
D
T
N
R
LIK
A
W
Q
-
-
-
K
P
EMIVV
S
E
C
YW
TA
A
AK
H
ADI
V
LP
ITT
SF
E
RN
DL
T
MTGD
YS
N
Q
-
H
I
V
PM
KQ
A
VA
A
Q
FE
ARNDFD
V
FADL
A
EL
L
K
P
GGKE
I
Y
TEG
K
D
E
MA
WLKF
F
Y
D
V
AQKG
AR
AQ
R
V
T
MP
M
F
N
A
F
W
QQ
NK
L
IEMR
R
S
E
K
NE
Q
Y
I
R
Y
G
D
FR
A
DP
V
K
N
A
L
G
TPSGKIEIYS
RT
L
E
K
FGYKDCPAH
P
TW
--
-
---
-
L
A
P
--
-
-
---
-
D
E
W
K
G
T
A
D
E
K
-
Q
LQL
L
TA
H
PA
H
R
L
HS
Q
LNYA
E
L
R
K
K
YAV
A
D
R
EPIT
I
HTE
DA
A
R
F
GIANGD
L
VRV
W
N
K
RG
Q
IL
TG
A
V
VT
DG
I
KK
GV
V
C
V
HE
GAW
P
D
L
E
-
-
-
N
G
L
CKN
GS
A
N
V
LTA
D
I
S
S
SQ
LA
NACA
G
N
S
A
LV
Y
IEKYTGNA
L
KLTAFDQPAVQA
fig|340197.5.peg.3254
Escherichia coli F11
MT
LT
RR
E
F
IK
H
S
G
I
AAG
T
L
-
---
-
-
---
-
--
V
V
T
S
AAP
LP
AW
A
E
EK
-
--
G
G
K
I
LTA
G
RWG
A
MNVE
VKD
GK
I
-
---
V
S
STG
A
-
-
-
-
LAKTIPNS
L
QSTAADQVHTTA
RI
Q
HP
MVRKSY
L
D
N
P
LQP
V
KG
RGE
DTYVQV
SW
EQ
AL
KL
I
HEQ
H
D
RI
R
K
A
N
G
PS
A
I
F
--
-
-
AG
SY
G
WR
S
S
G
V
LHK
A
QT
L
LQ
R
Y
MN
LA
GG
Y
S
GH
S
G
D
YST
GAAQ
V
I
MP
H
VV
GS
VEVYEQQTSW
P
L
IL
ENS
QV
VV
LW
G
M
NP
LN
T
LKIAWSSTDEQ
GL
E
Y
F-
-
H
QLK
KS
GK
P
V
I
A
IDP
I
C
S
E
T
IEFF
G
DNAT
W
IAPNM
GTD
V
AL
ML
GIA
HT
L
M
T
QG
K
H
D
KV
FL
E
KY
TT
GY
PQ
-----
-
--
-
-
-
-
FEE
Y
LT
G
KS
-
D
N
T
P
K
SA
A
WAAEITG
V
P
EA
QI
V
KLA
-
E
LM
AA
NRTMLMA
GWG
I
QRQ
Q
Y
GEQ
K
H
WMLVT
L
AA
ML
G
QI
G
T
P
GG
GF
G
FSYHYSNGGNP
T
R
V
G
GV----
-
-
LP
E
M
S
AAIAG
Q
A
S
-
-
-
--
E
A
A
D
D
G
G-
MTAI
PVARIV
D
ALENPGGKYQHN
GKE
QTYPN
IK
M
IW
-
W
AG
GGN
F
TH
H
Q
D
T
N
R
LIK
A
W
Q
-
-
-
K
P
EMIVV
S
E
C
YW
TA
A
AK
H
ADI
V
LP
ITT
SF
E
RN
DL
T
MTGD
YS
N
Q
-
H
I
V
PM
KQ
A
VA
A
Q
FE
ARNDFD
V
FADL
A
EL
L
K
P
GGKE
I
Y
TEG
K
D
E
MA
WLKF
F
Y
D
V
AQKG
AR
AQ
R
V
T
MP
M
F
N
A
F
W
QQ
NK
L
IEMR
R
S
E
K
NE
Q
Y
I
R
Y
G
D
FR
A
DP
V
K
N
A
L
G
TPSGKIEIYS
RT
L
E
K
FGYKDCPAH
P
TW
--
-
---
-
L
A
P
--
-
-
---
-
D
E
W
K
G
T
A
D
E
K
-
Q
LQL
L
TA
H
PA
H
R
L
HS
Q
LNYA
E
L
R
K
K
YAV
A
D
R
EPIT
I
HTE
DA
A
R
F
GIANGD
L
VRV
W
N
K
RG
Q
IL
TG
A
V
VT
DG
I
KK
GV
V
C
V
HE
GAW
P
D
L
E
-
-
-
N
G
L
CKN
GS
A
N
V
LTA
D
I
S
S
SQ
LA
NACA
G
N
S
A
LV
Y
IEKYTGNA
L
KLTAFDQPAVQA
fig|749550.3.peg.1925
Escherichia coli MS 200-1
MT
LT
RR
E
F
IK
H
S
G
I
AAG
T
L
-
---
-
-
---
-
--
V
V
T
S
AAP
LP
AW
A
E
EK
-
--
G
G
K
I
LTA
G
RWG
A
MNVE
VKD
GK
I
-
---
V
S
STG
A
-
-
-
-
LAKTIPNS
L
QSTAADQVHTTA
RI
Q
HP
MVRKSY
L
D
N
P
LQP
V
KG
RGE
DTYVQV
SW
EQ
AL
KL
I
HEQ
H
D
RI
R
K
A
N
G
PS
A
I
F
--
-
-
AG
SY
G
WR
S
S
G
V
LHK
A
QT
L
LQ
R
Y
MN
LA
GG
Y
S
GH
S
G
D
YST
GAAQ
V
I
MP
H
VV
GS
VEVYEQQTSW
P
L
IL
ENS
QV
VV
LW
G
M
NP
LN
T
LKIAWSSTDEQ
GL
E
Y
F-
-
H
QLK
KS
GK
P
V
I
A
IDP
I
C
S
E
T
IEFF
G
DNAT
W
IAPNM
GTD
V
AL
ML
GIA
HT
L
M
T
QG
K
H
D
KV
FL
E
KY
TT
GY
PQ
-----
-
--
-
-
-
-
FEE
Y
LT
G
KS
-
D
N
T
P
K
SA
A
WAAEITG
V
P
EA
QI
V
KLA
-
E
LM
AA
NRTMLMA
GWG
I
QRQ
Q
Y
GEQ
K
H
WMLVT
L
AA
ML
G
QI
G
T
P
GG
GF
G
FSYHYSNGGNP
T
R
V
G
GV----
-
-
LP
E
M
S
AAIAG
Q
A
S
-
-
-
--
E
A
A
D
D
G
G-
MTAI
PVARIV
D
ALENPGGKYQHN
GKE
QTYPN
IK
M
IW
-
W
AG
GGN
F
TH
H
Q
D
T
N
R
LIK
A
W
Q
-
-
-
K
P
EMIVV
S
E
C
YW
TA
A
AK
H
ADI
V
LP
ITT
SF
E
RN
DL
T
MTGD
YS
N
Q
-
H
I
V
PM
KQ
A
VA
A
Q
FE
ARNDFD
V
FADL
A
EL
L
K
P
GGKE
I
Y
TEG
K
D
E
MA
WLKF
F
Y
D
V
AQKG
AR
AQ
R
V
T
MP
M
F
N
A
F
W
QQ
NK
L
IEMR
R
S
E
K
NE
Q
Y
I
R
Y
G
D
FR
A
DP
V
K
N
A
L
G
TPSGKIEIYS
RT
L
E
K
FGYKDCPAH
P
TW
--
-
---
-
L
A
P
--
-
-
---
-
D
E
W
K
G
T
A
D
E
K
-
Q
LQL
L
TA
H
PA
H
R
L
HS
Q
LNYA
E
L
R
K
K
YAV
A
D
R
EPIT
I
HTE
DA
A
R
F
GIANGD
L
VRV
W
N
K
RG
Q
IL
TG
A
V
VT
DG
I
KK
GV
V
C
V
HE
GAW
P
D
L
E
-
-
-
N
G
L
CKN
GS
A
N
V
LTA
D
I
S
S
SQ
LA
NACA
G
N
S
A
LV
Y
IEKYTGNA
L
KLTAFDQPAVQA
fig|749527.3.peg.811
Escherichia coli MS 21-1
MT
LT
RR
E
F
IK
H
S
G
I
AAG
T
L
-
---
-
-
---
-
--
V
V
T
S
AAP
LP
AW
A
E
EK
-
--
G
G
K
I
LTA
G
RWG
A
MNVE
VKD
GK
I
-
---
V
S
STG
A
-
-
-
-
LAKTIPNS
L
QSTAADQVHTTA
RI
Q
HP
MVRKSY
L
D
N
P
LQP
V
KG
RGE
DTYVQV
SW
EQ
AL
KL
I
HEQ
H
D
RI
R
K
A
N
G
PS
A
I
F
--
-
-
AG
SY
G
WR
S
S
G
V
LHK
A
QT
L
LQ
R
Y
MN
LA
GG
Y
S
GH
S
G
D
YST
GAAQ
V
I
MP
H
VV
GS
VEVYEQQTSW
P
L
IL
ENS
QV
VV
LW
G
M
NP
LN
T
LKIAWSSTDEQ
GL
E
Y
F-
-
H
QLK
KS
GK
P
V
I
A
IDP
I
C
S
E
T
IEFF
G
DNAT
W
IAPNM
GTD
V
AL
ML
GIA
HT
L
M
T
QG
K
H
D
KV
FL
E
KY
TT
GY
PQ
-----
-
--
-
-
-
-
FEE
Y
LT
G
KS
-
D
N
T
P
K
SA
A
WAAEITG
V
P
EA
QI
V
KLA
-
E
LM
AA
NRTMLMA
GWG
I
QRQ
Q
Y
GEQ
K
H
WMLVT
L
AA
ML
G
QI
G
T
P
GG
GF
G
FSYHYSNGGNP
T
R
V
G
GV----
-
-
LP
E
M
S
AAIAG
Q
A
S
-
-
-
--
E
A
A
D
D
G
G-
MTAI
PVARIV
D
ALENPGGKYQHN
GKE
QTYPN
IK
M
IW
-
W
AG
GGN
F
TH
H
Q
D
T
N
R
LIK
A
W
Q
-
-
-
K
P
EMIVV
S
E
C
YW
TA
A
AK
H
ADI
V
LP
ITT
SF
E
RN
DL
T
MTGD
YS
N
Q
-
H
I
V
PM
KQ
A
VA
A
Q
FE
ARNDFD
V
FADL
A
EL
L
K
P
GGKE
I
Y
TEG
K
D
E
MA
WLKF
F
Y
D
V
AQKG
AR
AQ
R
V
T
MP
M
F
N
A
F
W
QQ
NK
L
IEMR
R
S
E
K
NE
Q
Y
I
R
Y
G
D
FR
A
DP
V
K
N
A
L
G
TPSGKIEIYS
RT
L
E
K
FGYKDCPAH
P
TW
--
-
---
-
L
A
P
--
-
-
---
-
D
E
W
K
G
T
A
D
E
K
-
Q
LQL
L
TA
H
PA
H
R
L
HS
Q
LNYA
E
L
R
K
K
YAV
A
D
R
EPIT
I
HTE
DA
A
R
F
GIANGD
L
VRV
W
N
K
RG
Q
IL
TG
A
V
VT
DG
I
KK
GV
V
C
V
HE
GAW
P
D
L
E
-
-
-
N
G
L
CKN
GS
A
N
V
LTA
D
I
S
S
SQ
LA
NACA
G
N
S
A
LV
Y
IEKYTGNA
L
KLTAFDQPAVQA
fig|656393.3.peg.1656
Escherichia coli H299 (14-813/814)
V
SRR
G
L
V
K
T
T
AIG
G
LA
M
A
SSA
L
T
LPF
S
RIAHAVD
S
ALP
AK
S
D
EK
V
I
W
S
A
C
T
VNCGSRC
P
LR
M
HV
V
D
GE
I
K
Y
VE
T
D
N
TG
D
D
N
Y
D
G
L
HQVRACLRGRS
M
RR
-----
R
V
Y
N
P
----
DRL
K
YPMKRVG
A
RGEGKFERISW
E
EA
Y
D
I
I
ATN
M
Q
R
L
I
K
E
YGNE
S
I
Y
LN
Y
G
T
G
TL
GG
T
M
T
R
S
WPP
G
NT
L
VA
RLMN
CC
GG
Y
L
NH
YG
D
YS
S
AQI
A
E
G
L
N
Y
TY
G
G
----
WA
DGNSP
S
DIENSKLVV
L
FGNNP
G
ET
------
RMSGGG
V
TY
YL
E
Q
AR
Q
KSNA
R
MI
I
IDPRY
T
DT
G
A
--
GREDEW
I
PIRPGTD
A
AL
VN
G
L
A
Y
V
M
ITEN
L
VDQ
A
FLDKYCVGYDEKTLPA
S
AP
K
N
G
HYKAYILGEG
P
D
G
V
AKTP
E
WA
S
Q
ITG
V
P
AD
K
IIKLAREIG
S
T
KPA
F
I
S
QGWGPQR
H
A
NGE
IA
T
RAI
S
ML
AI
LTGNVGI
N
GGNSG
-----------
A
REG
SYSLPF
V
R
M
P
T
L
E
NP
I
Q
T
S
IS
M
F
M
WTDAI
E
R
G
PE
MTA
L
R
-----
DGVR
---------
GK
D
KLDVPIK
M
IW
N
YAGN
C
L
I
NQH
S
E
IN
R
THE
I
LQD
D
K
KCE
L
IVVI
D
C
H
MT
S
SAKYADILLPD
C
T
AS
EQ
M
D
FA
LDAS
C
GNM
S
Y
V
I
FN
D
QV
IK
P
R
FE
C
K
T
IY
E
M
T
SE
L
AKRLG
--
V
E
Q
Q
FTEGR
T
Q
EE
W
MR
H
LY
----
A
Q
SR
E
A
I
P
E
L
P
T
F
E
E
F
R
KQ
GI
F
---
K
K
R
D
P
Q
G
H
H
VAY
K
AFR
E
DP
Q
ANPL
T
TPSGKIEIYS
QA
LA
D
IA
-------
A
TWEL
P
E
G
D
V
I
D
PLP
I
Y
TPG
F
E
S
Y
Q
D
P
L
N
K
Q
Y
PLQL
T
GFHYK
S
R
V
HS
T
YGN
V
D
V
LK
A
---
ACRQE
M
WINP
L
DAQ
K
RGI
N
NGD
K
VR
I
FN
D
RGE
V
H
IE
AKVTPR
MM
PGV
V
A
L
G
E
GAW
Y
D
P
D
T
-
-
K
R
V
D
K
GG
C
I
N
V
LT
T
Q
RPSP
-
LAKGNP
S
H
T
NLV
Q
V
EK
fig|749527.3.peg.2432
Escherichia coli MS 21-1 (14-813/814)
V
SRR
G
L
V
K
T
T
AIG
G
LA
M
A
SSA
L
T
LPF
S
RIAHAVD
S
ALP
AK
S
D
EK
V
I
W
S
A
C
T
VNCGSRC
P
LR
M
HV
V
D
GE
I
K
Y
VE
T
D
N
TG
D
D
N
Y
D
G
L
HQVRACLRGRS
M
RR
-----
R
V
Y
N
P
----
DRL
K
YPMKRVG
A
RGEGKFERISW
E
EA
Y
D
I
I
ATN
M
Q
R
L
I
K
E
YGNE
S
I
Y
LN
Y
G
T
G
TL
GG
T
M
T
R
S
WPP
G
NT
L
VA
RLMN
CC
GG
Y
L
NH
YG
D
YS
S
AQI
A
E
G
L
N
Y
TY
G
G
----
WA
DGNSP
S
DIENSKLVV
L
FGNNP
G
ET
------
RMSGGG
V
TY
YL
E
Q
AR
Q
KSNA
R
MI
I
IDPRY
T
DT
G
A
--
GREDEW
I
PIRPGTD
A
AL
VN
G
L
A
Y
V
M
ITEN
L
VDQ
A
FLDKYCVGYDEKTLPA
S
AP
K
N
G
HYKAYILGEG
P
D
G
V
AKTP
E
WA
S
Q
ITG
V
P
AD
K
IIKLAREIG
S
T
KPA
F
I
S
QGWGPQR
H
A
NGE
IA
T
RAI
S
ML
AI
LTGNVGI
N
GGNSG
-----------
A
REG
SYSLPF
V
R
M
P
T
L
E
NP
I
Q
T
S
IS
M
F
M
WTDAI
E
R
G
PE
MTA
L
R
-----
DGVR
---------
GK
D
KLDVPIK
M
IW
N
YAGN
C
L
I
NQH
S
E
IN
R
THE
I
LQD
D
K
KCE
L
IVVI
D
C
H
MT
S
SAKYADILLPD
C
T
AS
EQ
M
D
FA
LDAS
C
GNM
S
Y
V
I
FN
D
QV
IK
P
R
FE
C
K
T
IY
E
M
T
SE
L
AKRLG
--
V
E
Q
Q
FTEGR
T
Q
EE
W
MR
H
LY
----
A
Q
SR
E
A
I
P
E
L
P
T
F
E
E
F
R
KQ
GI
F
---
K
K
R
D
P
Q
G
H
H
VAY
K
AFR
E
DP
Q
ANPL
T
TPSGKIEIYS
QA
LA
D
IA
-------
A
TWEL
P
E
G
D
V
I
D
PLP
I
Y
TPG
F
E
S
Y
Q
D
P
L
N
K
Q
Y
PLQL
T
GFHYK
S
R
V
HS
T
YGN
V
D
V
LK
A
---
ACRQE
M
WINP
L
DAQ
K
RGI
N
NGD
K
VR
I
FN
D
RGE
V
H
IE
AKVTPR
MM
PGV
V
A
L
G
E
GAW
Y
D
P
D
T
-
-
K
R
V
D
K
GG
C
I
N
V
LT
T
Q
RPSP
-
LAKGNP
S
H
T
NLV
Q
V
EK
fig|439855.10.peg.2382
Escherichia coli SMS-3-5 (14-813/814)
V
SRR
G
L
V
K
T
T
AIG
G
LA
M
A
SSA
L
T
LPF
S
RIAHAVD
S
ALP
AK
S
D
EK
V
I
W
S
A
C
T
VNCGSRC
P
LR
M
HV
V
D
GE
I
K
Y
VE
T
D
N
TG
D
D
N
Y
D
G
L
HQVRACLRGRS
M
RR
-----
R
V
Y
N
P
----
DRL
K
YPMKRVG
A
RGEGKFERISW
E
EA
Y
D
I
I
ATN
M
Q
R
L
I
K
E
YGNE
S
I
Y
LN
Y
G
T
G
TL
GG
T
M
T
R
S
WPP
G
NT
L
VA
RLMN
CC
GG
Y
L
NH
YG
D
YS
S
AQI
A
E
G
L
N
Y
TY
G
G
----
WA
DGNSP
S
DIENSKLVV
L
FGNNP
G
ET
------
RMSGGG
V
TY
YL
E
Q
AR
Q
KSNA
R
MI
I
IDPRY
T
DT
G
A
--
GREDEW
I
PIRPGTD
A
AL
VN
G
L
A
Y
V
M
ITEN
L
VDQ
A
FLDKYCVGYDEKTLPA
S
AP
K
N
G
HYKAYILGEG
P
D
G
V
AKTP
E
WA
S
Q
ITG
V
P
AD
K
IIKLAREIG
S
T
KPA
F
I
S
QGWGPQR
H
A
NGE
IA
T
RAI
S
ML
AI
LTGNVGI
N
GGNSG
-----------
A
REG
SYSLPF
V
R
M
P
T
L
E
NP
I
Q
T
S
IS
M
F
M
WTDAI
E
R
G
PE
MTA
L
R
-----
DGVR
---------
GK
D
KLDVPIK
M
IW
N
YAGN
C
L
I
NQH
S
E
IN
R
THE
I
LQD
D
K
KCE
L
IVVI
D
C
H
MT
S
SAKYADILLPD
C
T
AS
EQ
M
D
FA
LDAS
C
GNM
S
Y
V
I
FN
D
QV
IK
P
R
FE
C
K
T
IY
E
M
T
SE
L
AKRLG
--
V
E
Q
Q
FTEGR
T
Q
EE
W
MR
H
LY
----
A
Q
SR
E
A
I
P
E
L
P
T
F
E
E
F
R
KQ
GI
F
---
K
K
R
D
P
Q
G
H
H
VAY
K
AFR
E
DP
Q
ANPL
T
TPSGKIEIYS
QA
LA
D
IA
-------
A
TWEL
P
E
G
D
V
I
D
PLP
I
Y
TPG
F
E
S
Y
Q
D
P
L
N
K
Q
Y
PLQL
T
GFHYK
S
R
V
HS
T
YGN
V
D
V
LK
A
---
ACRQE
M
WINP
L
DAQ
K
RGI
N
NGD
K
VR
I
FN
D
RGE
V
H
IE
AKVTPR
MM
PGV
V
A
L
G
E
GAW
Y
D
P
D
T
-
-
K
R
V
D
K
GG
C
I
N
V
LT
T
Q
RPSP
-
LAKGNP
S
H
T
NLV
Q
V
EK
fig|340186.3.peg.17
Escherichia coli E110019 (10-807/808)
ISRR
T
L
V
K
S
T
AIGSLALA
AGG
F
S
LPF
T
--
L
R
S
AAA
T
V
-
QQ
A
S
EK
V
I
WG
A
C
S
VNCGSRCALRLHVKD
NE
V
T
WVE
T
D
N
TG
S
D
E
Y
-
GNHQVRACLRGRSIRR
-----
RINHP
----
DRL
N
YPMKRVG
T
RGEGKFERISWDEALDTI
ASS
L
K
KT
V
E
Q
YGNEAV
Y
IQ
Y
S
S
G
IV
GGN
M
T
R
S
SPS
A
SA
-
VK
RLMN
CY
GG
S
L
NQ
YGSYSTAQIS
C
AMPY
TY
GS
-----
NDGNS
T
T
DIENSKLVVMFGNNPAET
------
RMSGGG
I
TY
LL
E
K
AREKSNA
K
MIVIDPRY
T
DTAA
--
GREDEWLPIRPGTD
A
AL
VA
GIAWVLI
N
EN
L
VDQPFLDKYCVGYDEKTLPA
D
AP
K
N
G
HYKAYILGEG
D
D
N
TAKTP
Q
WA
S
Q
ITGIP
VD
R
IIKLAREIG
T
AKPAYICQGWGPQRQ
A
NGE
L
T
A
RAIAML
PI
LTGNVGI
S
GGNSG
-----------
A
RE
S
TYTITI
E
R
LP
V
L
D
NPVKT
S
IS
C
F
S
WTDAIDHG
PQ
MTAIR
-----
DGVR
---------
GK
D
KLDVPIKFIW
N
YAGNTL
V
NQH
S
DIN
K
THE
I
LQD
E
SKCEMIV
I
IE
N
FMT
S
SAKYADILLPDLM
TV
EQED
I
I
PNDY
AGNMGY
L
I
FL
QP
V
TS
E
KFERKPIYW
I
LSEVAKRLGPDVYQ
K
FTEGR
T
Q
EQ
WL
Q
H
LY
----
AK
ML
A
K
D
P
A
L
P
S
Y
D
E
L
K
KM
GI
Y
---
KRK
D
PN
G
H
F
VAY
K
AFR
D
DP
E
ANPLKTPSGKIEIYS
SR
LA
E
IA
-------
R
TWEL
E
KDE
V
I
S
PLP
V
Y
AST
F
E
GW
N
S
P
E
R
R
T
F
PLQL
F
GFHYK
S
RTHS
T
YGNIDLLK
A
---
ACRQEVWINPIDAQ
K
RGIANGD
L
VRVFN
H
RGE
V
R
LP
AKVTPRILPGV
S
A
M
GQGAW
H
E
A
N
M
S
GD
K
I
DHGG
C
V
N
T
LT
T
L
RPSP
-
LAKGNP
Q
H
T
NLV
E
IEK
fig|340186.5.peg.18
Escherichia coli E110019 (10-807/808)
ISRR
T
L
V
K
S
T
AIGSLALA
AGG
F
S
LPF
T
--
L
R
S
AAA
T
V
-
QQ
A
S
EK
V
I
WG
A
C
S
VNCGSRCALRLHVKD
NE
V
T
WVE
T
D
N
TG
S
D
E
Y
-
GNHQVRACLRGRSIRR
-----
RINHP
----
DRL
N
YPMKRVG
T
RGEGKFERISWDEALDTI
ASS
L
K
KT
V
E
Q
YGNEAV
Y
IQ
Y
S
S
G
IV
GGN
M
T
R
S
SPS
A
SA
-
VK
RLMN
CY
GG
S
L
NQ
YGSYSTAQIS
C
AMPY
TY
GS
-----
NDGNS
T
T
DIENSKLVVMFGNNPAET
------
RMSGGG
I
TY
LL
E
K
AREKSNA
K
MIVIDPRY
T
DTAA
--
GREDEWLPIRPGTD
A
AL
VA
GIAWVLI
N
EN
L
VDQPFLDKYCVGYDEKTLPA
D
AP
K
N
G
HYKAYILGEG
D
D
N
TAKTP
Q
WA
S
Q
ITGIP
VD
R
IIKLAREIG
T
AKPAYICQGWGPQRQ
A
NGE
L
T
A
RAIAML
PI
LTGNVGI
S
GGNSG
-----------
A
RE
S
TYTITI
E
R
LP
V
L
D
NPVKT
S
IS
C
F
S
WTDAIDHG
PQ
MTAIR
-----
DGVR
---------
GK
D
KLDVPIKFIW
N
YAGNTL
V
NQH
S
DIN
K
THE
I
LQD
E
SKCEMIV
I
IE
N
FMT
S
SAKYADILLPDLM
TV
EQED
I
I
PNDY
AGNMGY
L
I
FL
QP
V
TS
E
KFERKPIYW
I
LSEVAKRLGPDVYQ
K
FTEGR
T
Q
EQ
WL
Q
H
LY
----
AK
ML
A
K
D
P
A
L
P
S
Y
D
E
L
K
KM
GI
Y
---
KRK
D
PN
G
H
F
VAY
K
AFR
D
DP
E
ANPLKTPSGKIEIYS
SR
LA
E
IA
-------
R
TWEL
E
KDE
V
I
S
PLP
V
Y
AST
F
E
GW
N
S
P
E
R
R
T
F
PLQL
F
GFHYK
S
RTHS
T
YGNIDLLK
A
---
ACRQEVWINPIDAQ
K
RGIANGD
L
VRVFN
H
RGE
V
R
LP
AKVTPRILPGV
S
A
M
GQGAW
H
E
A
N
M
S
GD
K
I
DHGG
C
V
N
T
LT
T
L
RPSP
-
LAKGNP
Q
H
T
NLV
E
IEK
fig|316401.4.peg.1867
Escherichia coli ETEC H10407 (10-807/808)
ISRR
T
L
V
K
S
T
AIGSLALA
AGG
F
S
LPF
T
--
L
R
N
AAA
A
V
-
QQ
A
R
EK
V
VWG
A
C
S
VNCGSRCALRLHVKD
NE
V
T
WVE
T
D
N
TG
S
D
E
Y
-
GNHQVRACLRGRSIRR
-----
RINHP
----
DRL
N
YPMKRVGKRGEGKFERISWDEALDTI
ASS
L
K
KT
V
E
Q
YGNEAV
Y
IQ
Y
S
S
G
IV
GGN
M
T
R
S
SPS
A
SA
-
VK
RLMN
CY
GG
S
L
NQ
YGSYSTAQIS
C
AMPY
TY
GS
-----
NDGNS
T
T
DIENSKLVVMFGNNPAET
------
RMSGGG
I
TY
LL
E
K
AREKSNA
K
MIVIDPRY
T
DTAA
--
GREDEWLPIRPGTD
A
AL
VA
GIAWVLI
N
EN
L
VDQPFLDKYCVGYDEKTLPA
N
AP
Q
N
G
HYKAYILGEG
D
D
K
TAKTP
Q
WA
S
Q
ITGIP
ED
R
IIKLAREIG
T
AKPAYICQGWGPQRQ
A
NGE
L
T
A
RAIAML
PI
LTGNVGI
S
GGNSG
-----------
A
RE
S
TYTITI
E
R
LP
V
L
D
NPVKT
S
IS
C
F
S
WTDAIDHG
PQ
MTAIR
-----
DGVR
---------
GK
D
KLDVPIKFIW
N
YAGNTL
V
NQH
S
DIN
K
THE
I
LQD
E
SKCEMIVVIE
N
FMT
S
SAKYADILLPDLM
TV
EQED
I
I
PNDY
AGNMGY
L
I
FL
QP
V
TS
E
KFERKPIYW
I
LSEVAKRLGPDVYQ
K
FTEGR
T
Q
EQ
WL
Q
H
LY
----
AK
ML
A
K
D
P
A
L
P
S
Y
D
E
L
K
KM
GI
Y
---
KRK
D
L
N
G
H
F
VAY
K
AFR
D
DP
E
ANPLKTPSGKIEIYS
SR
LA
E
IA
-------
R
TWEL
E
KDE
V
I
S
PLP
V
Y
AST
F
E
GW
N
S
P
E
R
R
T
F
PLQL
F
GFHYK
S
RTHS
T
YGNIDLLK
A
---
ACRQEVWINPIDAQ
K
RGIANGD
M
VRVFN
H
RGE
V
R
LP
AKVTPRILPGV
S
A
M
GQGAW
H
E
A
N
M
S
GD
K
I
DHGG
C
V
N
T
LT
T
L
RPSP
-
LAKGNP
Q
H
T
NLV
E
IEK
fig|595496.3.peg.1547
Escherichia coli BW2952 (10-807/808)
ISRR
T
L
V
K
S
T
AIGSLALA
AGG
F
S
LPF
T
--
L
R
N
AAA
A
V
-
QQ
A
R
EK
V
VWG
A
C
S
VNCGSRCALRLHVKD
NE
V
T
WVE
T
D
N
TG
S
D
E
Y
-
GNHQVRACLRGRSIRR
-----
RINHP
----
DRL
N
YPMKRVGKRGEGKFERISWDEALDTI
ASS
L
K
KT
V
E
Q
YGNEAV
Y
IQ
Y
S
S
G
IV
GGN
M
T
R
S
SPS
A
SA
-
VK
RLMN
CY
GG
S
L
NQ
YGSYSTAQIS
C
AMPY
TY
GS
-----
NDGNS
T
T
DIENSKLVVMFGNNPAET
------
RMSGGG
I
TY
LL
E
K
AREKSNA
K
MIVIDPRY
T
DTAA
--
GREDEWLPIRPGTD
A
AL
VA
GIAWVLI
N
EN
L
VDQPFLDKYCVGYDEKTLPA
D
AP
K
N
G
HYKAYILGEG
D
D
K
TAKTP
Q
WA
S
Q
ITGIP
ED
R
IIKLAREIG
T
AKPAYICQGWGPQRQ
A
NGE
L
T
A
RAIAML
PI
LTGNVGI
S
GGNSG
-----------
A
RE
S
TYTITI
E
R
LP
V
L
D
NPVKT
S
IS
C
F
S
WTDAIDHG
PQ
MTAIR
-----
DGVR
---------
GK
D
KLDVPIKFIW
N
YAGNTL
V
NQH
S
DIN
K
THE
I
LQD
E
SKCEMIVVIE
N
FMT
S
SAKYADILLPDLM
TV
EQED
I
I
PNDY
AGNMGY
L
I
FL
QP
V
TS
E
KFERKPIYW
I
LSEVAKRLGPDVYQ
K
FTEGR
T
Q
EQ
WL
Q
H
LY
----
AK
ML
A
K
D
P
A
L
P
S
Y
D
E
L
K
KM
GI
Y
---
KRK
D
PN
G
H
F
VAY
K
AFR
D
DP
E
ANPLKTPSGKIEIYS
SR
LA
E
IA
-------
R
TWEL
E
KDE
V
I
S
PLP
V
Y
AST
F
E
GW
N
S
P
E
R
R
T
F
PLQL
F
GFHYK
S
RTHS
T
YGNIDLLK
A
---
ACRQEVWINPIDAQ
K
RGIANGD
M
VRVFN
H
RGE
V
R
LP
AKVTPRILPGV
S
A
M
GQGAW
H
E
A
N
M
S
GD
K
I
DHGG
C
V
N
T
LT
T
L
RPSP
-
LAKGNP
Q
H
T
NLV
E
IEK
fig|536056.3.peg.2167
Escherichia coli DH1 (10-807/808)
ISRR
T
L
V
K
S
T
AIGSLALA
AGG
F
S
LPF
T
--
L
R
N
AAA
A
V
-
QQ
A
R
EK
V
VWG
A
C
S
VNCGSRCALRLHVKD
NE
V
T
WVE
T
D
N
TG
S
D
E
Y
-
GNHQVRACLRGRSIRR
-----
RINHP
----
DRL
N
YPMKRVGKRGEGKFERISWDEALDTI
ASS
L
K
KT
V
E
Q
YGNEAV
Y
IQ
Y
S
S
G
IV
GGN
M
T
R
S
SPS
A
SA
-
VK
RLMN
CY
GG
S
L
NQ
YGSYSTAQIS
C
AMPY
TY
GS
-----
NDGNS
T
T
DIENSKLVVMFGNNPAET
------
RMSGGG
I
TY
LL
E
K
AREKSNA
K
MIVIDPRY
T
DTAA
--
GREDEWLPIRPGTD
A
AL
VA
GIAWVLI
N
EN
L
VDQPFLDKYCVGYDEKTLPA
D
AP
K
N
G
HYKAYILGEG
D
D
K
TAKTP
Q
WA
S
Q
ITGIP
ED
R
IIKLAREIG
T
AKPAYICQGWGPQRQ
A
NGE
L
T
A
RAIAML
PI
LTGNVGI
S
GGNSG
-----------
A
RE
S
TYTITI
E
R
LP
V
L
D
NPVKT
S
IS
C
F
S
WTDAIDHG
PQ
MTAIR
-----
DGVR
---------
GK
D
KLDVPIKFIW
N
YAGNTL
V
NQH
S
DIN
K
THE
I
LQD
E
SKCEMIVVIE
N
FMT
S
SAKYADILLPDLM
TV
EQED
I
I
PNDY
AGNMGY
L
I
FL
QP
V
TS
E
KFERKPIYW
I
LSEVAKRLGPDVYQ
K
FTEGR
T
Q
EQ
WL
Q
H
LY
----
AK
ML
A
K
D
P
A
L
P
S
Y
D
E
L
K
KM
GI
Y
---
KRK
D
PN
G
H
F
VAY
K
AFR
D
DP
E
ANPLKTPSGKIEIYS
SR
LA
E
IA
-------
R
TWEL
E
KDE
V
I
S
PLP
V
Y
AST
F
E
GW
N
S
P
E
R
R
T
F
PLQL
F
GFHYK
S
RTHS
T
YGNIDLLK
A
---
ACRQEVWINPIDAQ
K
RGIANGD
M
VRVFN
H
RGE
V
R
LP
AKVTPRILPGV
S
A
M
GQGAW
H
E
A
N
M
S
GD
K
I
DHGG
C
V
N
T
LT
T
L
RPSP
-
LAKGNP
Q
H
T
NLV
E
IEK
fig|656414.3.peg.1889
Escherichia coli H736 (10-807/808)
ISRR
T
L
V
K
S
T
AIGSLALA
AGG
F
S
LPF
T
--
L
R
N
AAA
A
V
-
QQ
A
R
EK
V
VWG
A
C
S
VNCGSRCALRLHVKD
NE
V
T
WVE
T
D
N
TG
S
D
E
Y
-
GNHQVRACLRGRSIRR
-----
RINHP
----
DRL
N
YPMKRVGKRGEGKFERISWDEALDTI
ASS
L
K
KT
V
E
Q
YGNEAV
Y
IQ
Y
S
S
G
IV
GGN
M
T
R
S
SPS
A
SA
-
VK
RLMN
CY
GG
S
L
NQ
YGSYSTAQIS
C
AMPY
TY
GS
-----
NDGNS
T
T
DIENSKLVVMFGNNPAET
------
RMSGGG
I
TY
LL
E
K
AREKSNA
K
MIVIDPRY
T
DTAA
--
GREDEWLPIRPGTD
A
AL
VA
GIAWVLI
N
EN
L
VDQPFLDKYCVGYDEKTLPA
D
AP
K
N
G
HYKAYILGEG
D
D
K
TAKTP
Q
WA
S
Q
ITGIP
ED
R
IIKLAREIG
T
AKPAYICQGWGPQRQ
A
NGE
L
T
A
RAIAML
PI
LTGNVGI
S
GGNSG
-----------
A
RE
S
TYTITI
E
R
LP
V
L
D
NPVKT
S
IS
C
F
S
WTDAIDHG
PQ
MTAIR
-----
DGVR
---------
GK
D
KLDVPIKFIW
N
YAGNTL
V
NQH
S
DIN
K
THE
I
LQD
E
SKCEMIVVIE
N
FMT
S
SAKYADILLPDLM
TV
EQED
I
I
PNDY
AGNMGY
L
I
FL
QP
V
TS
E
KFERKPIYW
I
LSEVAKRLGPDVYQ
K
FTEGR
T
Q
EQ
WL
Q
H
LY
----
AK
ML
A
K
D
P
A
L
P
S
Y
D
E
L
K
KM
GI
Y
---
KRK
D
PN
G
H
F
VAY
K
AFR
D
DP
E
ANPLKTPSGKIEIYS
SR
LA
E
IA
-------
R
TWEL
E
KDE
V
I
S
PLP
V
Y
AST
F
E
GW
N
S
P
E
R
R
T
F
PLQL
F
GFHYK
S
RTHS
T
YGNIDLLK
A
---
ACRQEVWINPIDAQ
K
RGIANGD
M
VRVFN
H
RGE
V
R
LP
AKVTPRILPGV
S
A
M
GQGAW
H
E
A
N
M
S
GD
K
I
DHGG
C
V
N
T
LT
T
L
RPSP
-
LAKGNP
Q
H
T
NLV
E
IEK
fig|83333.1.peg.1573
Escherichia coli K12 (10-807/808)
ISRR
T
L
V
K
S
T
AIGSLALA
AGG
F
S
LPF
T
--
L
R
N
AAA
A
V
-
QQ
A
R
EK
V
VWG
A
C
S
VNCGSRCALRLHVKD
NE
V
T
WVE
T
D
N
TG
S
D
E
Y
-
GNHQVRACLRGRSIRR
-----
RINHP
----
DRL
N
YPMKRVGKRGEGKFERISWDEALDTI
ASS
L
K
KT
V
E
Q
YGNEAV
Y
IQ
Y
S
S
G
IV
GGN
M
T
R
S
SPS
A
SA
-
VK
RLMN
CY
GG
S
L
NQ
YGSYSTAQIS
C
AMPY
TY
GS
-----
NDGNS
T
T
DIENSKLVVMFGNNPAET
------
RMSGGG
I
TY
LL
E
K
AREKSNA
K
MIVIDPRY
T
DTAA
--
GREDEWLPIRPGTD
A
AL
VA
GIAWVLI
N
EN
L
VDQPFLDKYCVGYDEKTLPA
D
AP
K
N
G
HYKAYILGEG
D
D
K
TAKTP
Q
WA
S
Q
ITGIP
ED
R
IIKLAREIG
T
AKPAYICQGWGPQRQ
A
NGE
L
T
A
RAIAML
PI
LTGNVGI
S
GGNSG
-----------
A
RE
S
TYTITI
E
R
LP
V
L
D
NPVKT
S
IS
C
F
S
WTDAIDHG
PQ
MTAIR
-----
DGVR
---------
GK
D
KLDVPIKFIW
N
YAGNTL
V
NQH
S
DIN
K
THE
I
LQD
E
SKCEMIVVIE
N
FMT
S
SAKYADILLPDLM
TV
EQED
I
I
PNDY
AGNMGY
L
I
FL
QP
V
TS
E
KFERKPIYW
I
LSEVAKRLGPDVYQ
K
FTEGR
T
Q
EQ
WL
Q
H
LY
----
AK
ML
A
K
D
P
A
L
P
S
Y
D
E
L
K
KM
GI
Y
---
KRK
D
PN
G
H
F
VAY
K
AFR
D
DP
E
ANPLKTPSGKIEIYS
SR
LA
E
IA
-------
R
TWEL
E
KDE
V
I
S
PLP
V
Y
AST
F
E
GW
N
S
P
E
R
R
T
F
PLQL
F
GFHYK
S
RTHS
T
YGNIDLLK
A
---
ACRQEVWINPIDAQ
K
RGIANGD
M
VRVFN
H
RGE
V
R
LP
AKVTPRILPGV
S
A
M
GQGAW
H
E
A
N
M
S
GD
K
I
DHGG
C
V
N
T
LT
T
L
RPSP
-
LAKGNP
Q
H
T
NLV
E
IEK
fig|749538.3.peg.4136
Escherichia coli MS 116-1 (10-807/808)
ISRR
T
L
V
K
S
T
AIGSLALA
AGG
F
S
LPF
T
--
L
R
N
AAA
A
V
-
QQ
A
R
EK
V
VWG
A
C
S
VNCGSRCALRLHVKD
NE
V
T
WVE
T
D
N
TG
S
D
E
Y
-
GNHQVRACLRGRSIRR
-----
RINHP
----
DRL
N
YPMKRVGKRGEGKFERISWDEALDTI
ASS
L
K
KT
V
E
Q
YGNEAV
Y
IQ
Y
S
S
G
IV
GGN
M
T
R
S
SPS
A
SA
-
VK
RLMN
CY
GG
S
L
NQ
YGSYSTAQIS
C
AMPY
TY
GS
-----
NDGNS
T
T
DIENSKLVVMFGNNPAET
------
RMSGGG
I
TY
LL
E
K
AREKSNA
K
MIVIDPRY
T
DTAA
--
GREDEWLPIRPGTD
A
AL
VA
GIAWVLI
N
EN
L
VDQPFLDKYCVGYDEKTLPA
D
AP
K
N
G
HYKAYILGEG
D
D
K
TAKTP
Q
WA
S
Q
ITGIP
ED
R
IIKLAREIG
T
AKPAYICQGWGPQRQ
A
NGE
L
T
A
RAIAML
PI
LTGNVGI
S
GGNSG
-----------
A
RE
S
TYTITI
E
R
LP
V
L
D
NPVKT
S
IS
C
F
S
WTDAIDHG
PQ
MTAIR
-----
DGVR
---------
GK
D
KLDVPIKFIW
N
YAGNTL
V
NQH
S
DIN
K
THE
I
LQD
E
SKCEMIVVIE
N
FMT
S
SAKYADILLPDLM
TV
EQED
I
I
PNDY
AGNMGY
L
I
FL
QP
V
TS
E
KFERKPIYW
I
LSEVAKRLGPDVYQ
K
FTEGR
T
Q
EQ
WL
Q
H
LY
----
AK
ML
A
K
D
P
A
L
P
S
Y
D
E
L
K
KM
GI
Y
---
KRK
D
PN
G
H
F
VAY
K
AFR
D
DP
E
ANPLKTPSGKIEIYS
SR
LA
E
IA
-------
R
TWEL
E
KDE
V
I
S
PLP
V
Y
AST
F
E
GW
N
S
P
E
R
R
T
F
PLQL
F
GFHYK
S
RTHS
T
YGNIDLLK
A
---
ACRQEVWINPIDAQ
K
RGIANGD
M
VRVFN
H
RGE
V
R
LP
AKVTPRILPGV
S
A
M
GQGAW
H
E
A
N
M
S
GD
K
I
DHGG
C
V
N
T
LT
T
L
RPSP
-
LAKGNP
Q
H
T
NLV
E
IEK
fig|749540.3.peg.4220
Escherichia coli MS 146-1 (10-807/808)
ISRR
T
L
V
K
S
T
AIGSLALA
AGG
F
S
LPF
T
--
L
R
N
AAA
A
V
-
QQ
A
R
EK
V
VWG
A
C
S
VNCGSRCALRLHVKD
NE
V
T
WVE
T
D
N
TG
S
D
E
Y
-
GNHQVRACLRGRSIRR
-----
RINHP
----
DRL
N
YPMKRVGKRGEGKFERISWDEALDTI
ASS
L
K
KT
V
E
Q
YGNEAV
Y
IQ
Y
S
S
G
IV
GGN
M
T
R
S
SPS
A
SA
-
VK
RLMN
CY
GG
S
L
NQ
YGSYSTAQIS
C
AMPY
TY
GS
-----
NDGNS
T
T
DIENSKLVVMFGNNPAET
------
RMSGGG
I
TY
LL
E
K
AREKSNA
K
MIVIDPRY
T
DTAA
--
GREDEWLPIRPGTD
A
AL
VA
GIAWVLI
N
EN
L
VDQPFLDKYCVGYDEKTLPA
D
AP
K
N
G
HYKAYILGEG
D
D
K
TAKTP
Q
WA
S
Q
ITGIP
ED
R
IIKLAREIG
T
AKPAYICQGWGPQRQ
A
NGE
L
T
A
RAIAML
PI
LTGNVGI
S
GGNSG
-----------
A
RE
S
TYTITI
E
R
LP
V
L
D
NPVKT
S
IS
C
F
S
WTDAIDHG
PQ
MTAIR
-----
DGVR
---------
GK
D
KLDVPIKFIW
N
YAGNTL
V
NQH
S
DIN
K
THE
I
LQD
E
SKCEMIVVIE
N
FMT
S
SAKYADILLPDLM
TV
EQED
I
I
PNDY
AGNMGY
L
I
FL
QP
V
TS
E
KFERKPIYW
I
LSEVAKRLGPDVYQ
K
FTEGR
T
Q
EQ
WL
Q
H
LY
----
AK
ML
A
K
D
P
A
L
P
S
Y
D
E
L
K
KM
GI
Y
---
KRK
D
PN
G
H
F
VAY
K
AFR
D
DP
E
ANPLKTPSGKIEIYS
SR
LA
E
IA
-------
R
TWEL
E
KDE
V
I
S
PLP
V
Y
AST
F
E
GW
N
S
P
E
R
R
T
F
PLQL
F
GFHYK
S
RTHS
T
YGNIDLLK
A
---
ACRQEVWINPIDAQ
K
RGIANGD
M
VRVFN
H
RGE
V
R
LP
AKVTPRILPGV
S
A
M
GQGAW
H
E
A
N
M
S
GD
K
I
DHGG
C
V
N
T
LT
T
L
RPSP
-
LAKGNP
Q
H
T
NLV
E
IEK
fig|749548.3.peg.4734
Escherichia coli MS 196-1 (10-807/808)
ISRR
T
L
V
K
S
T
AIGSLALA
AGG
F
S
LPF
T
--
L
R
N
AAA
A
V
-
QQ
A
R
EK
V
VWG
A
C
S
VNCGSRCALRLHVKD
NE
V
T
WVE
T
D
N
TG
S
D
E
Y
-
GNHQVRACLRGRSIRR
-----
RINHP
----
DRL
N
YPMKRVGKRGEGKFERISWDEALDTI
ASS
L
K
KT
V
E
Q
YGNEAV
Y
IQ
Y
S
S
G
IV
GGN
M
T
R
S
SPS
A
SA
-
VK
RLMN
CY
GG
S
L
NQ
YGSYSTAQIS
C
AMPY
TY
GS
-----
NDGNS
T
T
DIENSKLVVMFGNNPAET
------
RMSGGG
I
TY
LL
E
K
AREKSNA
K
MIVIDPRY
T
DTAA
--
GREDEWLPIRPGTD
A
AL
VA
GIAWVLI
N
EN
L
VDQPFLDKYCVGYDEKTLPA
D
AP
K
N
G
HYKAYILGEG
D
D
K
TAKTP
Q
WA
S
Q
ITGIP
ED
R
IIKLAREIG
T
AKPAYICQGWGPQRQ
A
NGE
L
T
A
RAIAML
PI
LTGNVGI
S
GGNSG
-----------
A
RE
S
TYTITI
E
R
LP
V
L
D
NPVKT
S
IS
C
F
S
WTDAIDHG
PQ
MTAIR
-----
DGVR
---------
GK
D
KLDVPIKFIW
N
YAGNTL
V
NQH
S
DIN
K
THE
I
LQD
E
SKCEMIVVIE
N
FMT
S
SAKYADILLPDLM
TV
EQED
I
I
PNDY
AGNMGY
L
I
FL
QP
V
TS
E
KFERKPIYW
I
LSEVAKRLGPDVYQ
K
FTEGR
T
Q
EQ
WL
Q
H
LY
----
AK
ML
A
K
D
P
A
L
P
S
Y
D
E
L
K
KM
GI
Y
---
KRK
D
PN
G
H
F
VAY
K
AFR
D
DP
E
ANPLKTPSGKIEIYS
SR
LA
E
IA
-------
R
TWEL
E
KDE
V
I
S
PLP
V
Y
AST
F
E
GW
N
S
P
E
R
R
T
F
PLQL
F
GFHYK
S
RTHS
T
YGNIDLLK
A
---
ACRQEVWINPIDAQ
K
RGIANGD
M
VRVFN
H
RGE
V
R
LP
AKVTPRILPGV
S
A
M
GQGAW
H
E
A
N
M
S
GD
K
I
DHGG
C
V
N
T
LT
T
L
RPSP
-
LAKGNP
Q
H
T
NLV
E
IEK
fig|316407.3.peg.1544
Escherichia coli W3110 (10-807/808)
ISRR
T
L
V
K
S
T
AIGSLALA
AGG
F
S
LPF
T
--
L
R
N
AAA
A
V
-
QQ
A
R
EK
V
VWG
A
C
S
VNCGSRCALRLHVKD
NE
V
T
WVE
T
D
N
TG
S
D
E
Y
-
GNHQVRACLRGRSIRR
-----
RINHP
----
DRL
N
YPMKRVGKRGEGKFERISWDEALDTI
ASS
L
K
KT
V
E
Q
YGNEAV
Y
IQ
Y
S
S
G
IV
GGN
M
T
R
S
SPS
A
SA
-
VK
RLMN
CY
GG
S
L
NQ
YGSYSTAQIS
C
AMPY
TY
GS
-----
NDGNS
T
T
DIENSKLVVMFGNNPAET
------
RMSGGG
I
TY
LL
E
K
AREKSNA
K
MIVIDPRY
T
DTAA
--
GREDEWLPIRPGTD
A
AL
VA
GIAWVLI
N
EN
L
VDQPFLDKYCVGYDEKTLPA
D
AP
K
N
G
HYKAYILGEG
D
D
K
TAKTP
Q
WA
S
Q
ITGIP
ED
R
IIKLAREIG
T
AKPAYICQGWGPQRQ
A
NGE
L
T
A
RAIAML
PI
LTGNVGI
S
GGNSG
-----------
A
RE
S
TYTITI
E
R
LP
V
L
D
NPVKT
S
IS
C
F
S
WTDAIDHG
PQ
MTAIR
-----
DGVR
---------
GK
D
KLDVPIKFIW
N
YAGNTL
V
NQH
S
DIN
K
THE
I
LQD
E
SKCEMIVVIE
N
FMT
S
SAKYADILLPDLM
TV
EQED
I
I
PNDY
AGNMGY
L
I
FL
QP
V
TS
E
KFERKPIYW
I
LSEVAKRLGPDVYQ
K
FTEGR
T
Q
EQ
WL
Q
H
LY
----
AK
ML
A
K
D
P
A
L
P
S
Y
D
E
L
K
KM
GI
Y
---
KRK
D
PN
G
H
F
VAY
K
AFR
D
DP
E
ANPLKTPSGKIEIYS
SR
LA
E
IA
-------
R
TWEL
E
KDE
V
I
S
PLP
V
Y
AST
F
E
GW
N
S
P
E
R
R
T
F
PLQL
F
GFHYK
S
RTHS
T
YGNIDLLK
A
---
ACRQEVWINPIDAQ
K
RGIANGD
M
VRVFN
H
RGE
V
R
LP
AKVTPRILPGV
S
A
M
GQGAW
H
E
A
N
M
S
GD
K
I
DHGG
C
V
N
T
LT
T
L
RPSP
-
LAKGNP
Q
H
T
NLV
E
IEK
fig|316385.5.peg.1699
Escherichia coli str. K-12 substr. DH10B (10-807/808)
ISRR
T
L
V
K
S
T
AIGSLALA
AGG
F
S
LPF
T
--
L
R
N
AAA
A
V
-
QQ
A
R
EK
V
VWG
A
C
S
VNCGSRCALRLHVKD
NE
V
T
WVE
T
D
N
TG
S
D
E
Y
-
GNHQVRACLRGRSIRR
-----
RINHP
----
DRL
N
YPMKRVGKRGEGKFERISWDEALDTI
ASS
L
K
KT
V
E
Q
YGNEAV
Y
IQ
Y
S
S
G
IV
GGN
M
T
R
S
SPS
A
SA
-
VK
RLMN
CY
GG
S
L
NQ
YGSYSTAQIS
C
AMPY
TY
GS
-----
NDGNS
T
T
DIENSKLVVMFGNNPAET
------
RMSGGG
I
TY
LL
E
K
AREKSNA
K
MIVIDPRY
T
DTAA
--
GREDEWLPIRPGTD
A
AL
VA
GIAWVLI
N
EN
L
VDQPFLDKYCVGYDEKTLPA
D
AP
K
N
G
HYKAYILGEG
D
D
K
TAKTP
Q
WA
S
Q
ITGIP
ED
R
IIKLAREIG
T
AKPAYICQGWGPQRQ
A
NGE
L
T
A
RAIAML
PI
LTGNVGI
S
GGNSG
-----------
A
RE
S
TYTITI
E
R
LP
V
L
D
NPVKT
S
IS
C
F
S
WTDAIDHG
PQ
MTAIR
-----
DGVR
---------
GK
D
KLDVPIKFIW
N
YAGNTL
V
NQH
S
DIN
K
THE
I
LQD
E
SKCEMIVVIE
N
FMT
S
SAKYADILLPDLM
TV
EQED
I
I
PNDY
AGNMGY
L
I
FL
QP
V
TS
E
KFERKPIYW
I
LSEVAKRLGPDVYQ
K
FTEGR
T
Q
EQ
WL
Q
H
LY
----
AK
ML
A
K
D
P
A
L
P
S
Y
D
E
L
K
KM
GI
Y
---
KRK
D
PN
G
H
F
VAY
K
AFR
D
DP
E
ANPLKTPSGKIEIYS
SR
LA
E
IA
-------
R
TWEL
E
KDE
V
I
S
PLP
V
Y
AST
F
E
GW
N
S
P
E
R
R
T
F
PLQL
F
GFHYK
S
RTHS
T
YGNIDLLK
A
---
ACRQEVWINPIDAQ
K
RGIANGD
M
VRVFN
H
RGE
V
R
LP
AKVTPRILPGV
S
A
M
GQGAW
H
E
A
N
M
S
GD
K
I
DHGG
C
V
N
T
LT
T
L
RPSP
-
LAKGNP
Q
H
T
NLV
E
IEK
fig|316385.7.peg.1744
Escherichia coli str. K-12 substr. DH10B (10-807/808)
ISRR
T
L
V
K
S
T
AIGSLALA
AGG
F
S
LPF
T
--
L
R
N
AAA
A
V
-
QQ
A
R
EK
V
VWG
A
C
S
VNCGSRCALRLHVKD
NE
V
T
WVE
T
D
N
TG
S
D
E
Y
-
GNHQVRACLRGRSIRR
-----
RINHP
----
DRL
N
YPMKRVGKRGEGKFERISWDEALDTI
ASS
L
K
KT
V
E
Q
YGNEAV
Y
IQ
Y
S
S
G
IV
GGN
M
T
R
S
SPS
A
SA
-
VK
RLMN
CY
GG
S
L
NQ
YGSYSTAQIS
C
AMPY
TY
GS
-----
NDGNS
T
T
DIENSKLVVMFGNNPAET
------
RMSGGG
I
TY
LL
E
K
AREKSNA
K
MIVIDPRY
T
DTAA
--
GREDEWLPIRPGTD
A
AL
VA
GIAWVLI
N
EN
L
VDQPFLDKYCVGYDEKTLPA
D
AP
K
N
G
HYKAYILGEG
D
D
K
TAKTP
Q
WA
S
Q
ITGIP
ED
R
IIKLAREIG
T
AKPAYICQGWGPQRQ
A
NGE
L
T
A
RAIAML
PI
LTGNVGI
S
GGNSG
-----------
A
RE
S
TYTITI
E
R
LP
V
L
D
NPVKT
S
IS
C
F
S
WTDAIDHG
PQ
MTAIR
-----
DGVR
---------
GK
D
KLDVPIKFIW
N
YAGNTL
V
NQH
S
DIN
K
THE
I
LQD
E
SKCEMIVVIE
N
FMT
S
SAKYADILLPDLM
TV
EQED
I
I
PNDY
AGNMGY
L
I
FL
QP
V
TS
E
KFERKPIYW
I
LSEVAKRLGPDVYQ
K
FTEGR
T
Q
EQ
WL
Q
H
LY
----
AK
ML
A
K
D
P
A
L
P
S
Y
D
E
L
K
KM
GI
Y
---
KRK
D
PN
G
H
F
VAY
K
AFR
D
DP
E
ANPLKTPSGKIEIYS
SR
LA
E
IA
-------
R
TWEL
E
KDE
V
I
S
PLP
V
Y
AST
F
E
GW
N
S
P
E
R
R
T
F
PLQL
F
GFHYK
S
RTHS
T
YGNIDLLK
A
---
ACRQEVWINPIDAQ
K
RGIANGD
M
VRVFN
H
RGE
V
R
LP
AKVTPRILPGV
S
A
M
GQGAW
H
E
A
N
M
S
GD
K
I
DHGG
C
V
N
T
LT
T
L
RPSP
-
LAKGNP
Q
H
T
NLV
E
IEK
fig|511145.12.peg.1658
Escherichia coli str. K-12 substr. MG1655 (10-807/808)
ISRR
T
L
V
K
S
T
AIGSLALA
AGG
F
S
LPF
T
--
L
R
N
AAA
A
V
-
QQ
A
R
EK
V
VWG
A
C
S
VNCGSRCALRLHVKD
NE
V
T
WVE
T
D
N
TG
S
D
E
Y
-
GNHQVRACLRGRSIRR
-----
RINHP
----
DRL
N
YPMKRVGKRGEGKFERISWDEALDTI
ASS
L
K
KT
V
E
Q
YGNEAV
Y
IQ
Y
S
S
G
IV
GGN
M
T
R
S
SPS
A
SA
-
VK
RLMN
CY
GG
S
L
NQ
YGSYSTAQIS
C
AMPY
TY
GS
-----
NDGNS
T
T
DIENSKLVVMFGNNPAET
------
RMSGGG
I
TY
LL
E
K
AREKSNA
K
MIVIDPRY
T
DTAA
--
GREDEWLPIRPGTD
A
AL
VA
GIAWVLI
N
EN
L
VDQPFLDKYCVGYDEKTLPA
D
AP
K
N
G
HYKAYILGEG
D
D
K
TAKTP
Q
WA
S
Q
ITGIP
ED
R
IIKLAREIG
T
AKPAYICQGWGPQRQ
A
NGE
L
T
A
RAIAML
PI
LTGNVGI
S
GGNSG
-----------
A
RE
S
TYTITI
E
R
LP
V
L
D
NPVKT
S
IS
C
F
S
WTDAIDHG
PQ
MTAIR
-----
DGVR
---------
GK
D
KLDVPIKFIW
N
YAGNTL
V
NQH
S
DIN
K
THE
I
LQD
E
SKCEMIVVIE
N
FMT
S
SAKYADILLPDLM
TV
EQED
I
I
PNDY
AGNMGY
L
I
FL
QP
V
TS
E
KFERKPIYW
I
LSEVAKRLGPDVYQ
K
FTEGR
T
Q
EQ
WL
Q
H
LY
----
AK
ML
A
K
D
P
A
L
P
S
Y
D
E
L
K
KM
GI
Y
---
KRK
D
PN
G
H
F
VAY
K
AFR
D
DP
E
ANPLKTPSGKIEIYS
SR
LA
E
IA
-------
R
TWEL
E
KDE
V
I
S
PLP
V
Y
AST
F
E
GW
N
S
P
E
R
R
T
F
PLQL
F
GFHYK
S
RTHS
T
YGNIDLLK
A
---
ACRQEVWINPIDAQ
K
RGIANGD
M
VRVFN
H
RGE
V
R
LP
AKVTPRILPGV
S
A
M
GQGAW
H
E
A
N
M
S
GD
K
I
DHGG
C
V
N
T
LT
T
L
RPSP
-
LAKGNP
Q
H
T
NLV
E
IEK
fig|511145.6.peg.1642
Escherichia coli str. K-12 substr. MG1655 (10-807/808)
ISRR
T
L
V
K
S
T
AIGSLALA
AGG
F
S
LPF
T
--
L
R
N
AAA
A
V
-
QQ
A
R
EK
V
VWG
A
C
S
VNCGSRCALRLHVKD
NE
V
T
WVE
T
D
N
TG
S
D
E
Y
-
GNHQVRACLRGRSIRR
-----
RINHP
----
DRL
N
YPMKRVGKRGEGKFERISWDEALDTI
ASS
L
K
KT
V
E
Q
YGNEAV
Y
IQ
Y
S
S
G
IV
GGN
M
T
R
S
SPS
A
SA
-
VK
RLMN
CY
GG
S
L
NQ
YGSYSTAQIS
C
AMPY
TY
GS
-----
NDGNS
T
T
DIENSKLVVMFGNNPAET
------
RMSGGG
I
TY
LL
E
K
AREKSNA
K
MIVIDPRY
T
DTAA
--
GREDEWLPIRPGTD
A
AL
VA
GIAWVLI
N
EN
L
VDQPFLDKYCVGYDEKTLPA
D
AP
K
N
G
HYKAYILGEG
D
D
K
TAKTP
Q
WA
S
Q
ITGIP
ED
R
IIKLAREIG
T
AKPAYICQGWGPQRQ
A
NGE
L
T
A
RAIAML
PI
LTGNVGI
S
GGNSG
-----------
A
RE
S
TYTITI
E
R
LP
V
L
D
NPVKT
S
IS
C
F
S
WTDAIDHG
PQ
MTAIR
-----
DGVR
---------
GK
D
KLDVPIKFIW
N
YAGNTL
V
NQH
S
DIN
K
THE
I
LQD
E
SKCEMIVVIE
N
FMT
S
SAKYADILLPDLM
TV
EQED
I
I
PNDY
AGNMGY
L
I
FL
QP
V
TS
E
KFERKPIYW
I
LSEVAKRLGPDVYQ
K
FTEGR
T
Q
EQ
WL
Q
H
LY
----
AK
ML
A
K
D
P
A
L
P
S
Y
D
E
L
K
KM
GI
Y
---
KRK
D
PN
G
H
F
VAY
K
AFR
D
DP
E
ANPLKTPSGKIEIYS
SR
LA
E
IA
-------
R
TWEL
E
KDE
V
I
S
PLP
V
Y
AST
F
E
GW
N
S
P
E
R
R
T
F
PLQL
F
GFHYK
S
RTHS
T
YGNIDLLK
A
---
ACRQEVWINPIDAQ
K
RGIANGD
M
VRVFN
H
RGE
V
R
LP
AKVTPRILPGV
S
A
M
GQGAW
H
E
A
N
M
S
GD
K
I
DHGG
C
V
N
T
LT
T
L
RPSP
-
LAKGNP
Q
H
T
NLV
E
IEK
fig|562.375.peg.1686
Escherichia coli EC4100B (10-807/808)
ISRR
T
L
V
K
S
T
AIGSLALA
AGG
F
S
LPF
T
--
L
R
S
AAA
T
V
-
QQ
A
S
EK
V
I
WG
A
C
S
VNCGSRCALRLHVKD
NE
V
T
WVE
T
D
N
TG
S
D
E
Y
-
GNHQVRACLRGRSIRR
-----
RINHP
----
DRL
N
YPMKRVG
T
RGEGKFERISWDEALDTI
ASS
L
K
KT
V
E
Q
YGNEAV
Y
IQ
Y
S
S
G
IV
GGN
M
T
R
S
SPS
A
SA
-
VK
RLMN
CY
GG
S
L
NQ
YGSYSTAQIS
C
AMPY
TY
GS
-----
NDGNS
T
T
DIENSKLVVMFGNNPAET
------
RMSGGG
I
TY
LL
E
K
AREKSNA
K
MIVIDPRY
T
DTAA
--
GREDEWLPIRPGTD
A
AL
VA
GIAWVLI
N
EN
L
VDQPFLDKYCVGYDEKTLPA
D
AP
K
N
G
HYKAYILGEG
D
D
N
TAKTP
Q
WA
S
Q
ITGIP
VD
R
IIKLAREIG
T
AKPAYICQGWGPQRQ
A
NGE
L
T
A
RAIAML
PI
LTGNVGI
S
GGNSG
-----------
A
RE
S
TYTITI
E
R
LP
V
L
D
NPVKT
S
IS
C
F
S
WTDAIDHG
PQ
MTAIR
-----
DGVR
---------
GK
D
KLDVPIKFIW
N
YAGNTL
V
NQH
S
DIN
K
THE
I
LQD
E
SKCEMIVVIE
N
FMT
S
SAKYADILLPDLM
TV
EQED
I
I
PNDY
AGNMGY
L
I
FL
QP
V
TS
E
KFERKPIYW
I
LSEVAKRLGPDVYQ
K
FTEGR
T
Q
EQ
WL
Q
H
LY
----
AK
ML
A
K
D
P
A
L
P
S
Y
D
E
L
K
KM
GI
Y
---
KRK
D
PN
G
H
F
VAY
K
AFR
D
DP
E
ANPLKTPSGKIEIYS
SK
LA
E
IA
-------
R
TWEL
E
KDE
V
I
S
PLP
V
Y
AST
F
E
GWD
S
P
E
R
R
T
F
PLQL
F
GFHYK
S
RTHS
T
YGNIDLLK
A
---
ACRQEVWINPIDAQ
K
RGIANGD
M
VRVFN
H
RGE
V
R
LP
AKVTPRILPGV
S
A
M
GQGAW
H
E
A
N
M
S
GD
K
I
DHGG
C
V
N
T
LT
T
L
RPSP
-
LAKGNP
Q
H
T
NLV
E
IEK
fig|749532.3.peg.1355
Escherichia coli MS 78-1 (10-807/808)
ISRR
T
L
V
K
S
T
AIGSLALA
AGG
F
S
LPF
T
--
L
R
S
AAA
T
V
-
QQ
A
S
EK
V
I
WG
A
C
S
VNCGSRCALRLHVKD
NE
V
T
WVE
T
D
N
TG
S
D
E
Y
-
GNHQVRACLRGRSIRR
-----
RINHP
----
DRL
N
YPMKRVG
T
RGEGKFERISWDEALDTI
ASS
L
K
KT
V
E
Q
YGNEAV
Y
IQ
Y
S
S
G
IV
GGN
M
T
R
S
SPS
A
SA
-
VK
RLMN
CY
GG
S
L
NQ
YGSYSTAQIS
C
AMPY
TY
GS
-----
NDGNS
T
T
DIENSKLVVMFGNNPAET
------
RMSGGG
I
TY
LL
E
K
AREKSNA
K
MIVIDPRY
T
DTAA
--
GREDEWLPIRPGTD
A
AL
VA
GIAWVLI
N
EN
L
VDQPFLDKYCVGYDEKTLPA
D
AP
K
N
G
HYKAYILGEG
D
D
N
TAKTP
Q
WA
S
Q
ITGIP
VD
R
IIKLAREIG
T
AKPAYICQGWGPQRQ
A
NGE
L
T
A
RAIAML
PI
LTGNVGI
S
GGNSG
-----------
A
RE
S
TYTITI
E
R
LP
V
L
D
NPVKT
S
IS
C
F
S
WTDAIDHG
PQ
MTAIR
-----
DGVR
---------
GK
D
KLDVPIKFIW
N
YAGNTL
V
NQH
S
DIN
K
THE
I
LQD
E
SKCEMIVVIE
N
FMT
S
SAKYADILLPDLM
TV
EQED
I
I
PNDY
AGNMGY
L
I
FL
QP
V
TS
E
KFERKPIYW
I
LSEVAKRLGPDVYQ
K
FTEGR
T
Q
EQ
WL
Q
H
LY
----
AK
ML
A
K
D
P
A
L
P
S
Y
D
E
L
K
KM
GI
Y
---
KRK
D
PN
G
H
F
VAY
K
AFR
D
DP
E
ANPLKTPSGKIEIYS
SK
LA
E
IA
-------
R
TWEL
E
KDE
V
I
S
PLP
V
Y
AST
F
E
GWD
S
P
E
R
R
T
F
PLQL
F
GFHYK
S
RTHS
T
YGNIDLLK
A
---
ACRQEVWINPIDAQ
K
RGIANGD
M
VRVFN
H
RGE
V
R
LP
AKVTPRILPGV
S
A
M
GQGAW
H
E
A
N
M
S
GD
K
I
DHGG
C
V
N
T
LT
T
L
RPSP
-
LAKGNP
Q
H
T
NLV
E
IEK
fig|409438.11.peg.1855
Escherichia coli SE11 (10-807/808)
ISRR
T
L
V
K
S
T
AIGSLALA
AGG
F
S
LPF
T
--
L
R
S
AAA
T
V
-
QQ
A
S
EK
V
I
WG
A
C
S
VNCGSRCALRLHVKD
NE
V
T
WVE
T
D
N
TG
S
D
E
Y
-
GNHQVRACLRGRSIRR
-----
RINHP
----
DRL
N
YPMKRVG
T
RGEGKFERISWDEALDTI
ASS
L
K
KT
V
E
Q
YGNEAV
Y
IQ
Y
S
S
G
IV
GGN
M
T
R
S
SPS
A
SA
-
VK
RLMN
CY
GG
S
L
NQ
YGSYSTAQIS
C
AMPY
TY
GS
-----
NDGNS
T
T
DIENSKLVVMFGNNPAET
------
RMSGGG
I
TY
LL
E
K
AREKSNA
K
MIVIDPRY
T
DTAA
--
GREDEWLPIRPGTD
A
AL
VA
GIAWVLI
N
EN
L
VDQPFLDKYCVGYDEKTLPA
D
AP
K
N
G
HYKAYILGEG
D
D
N
TAKTP
Q
WA
S
Q
ITGIP
VD
R
IIKLAREIG
T
AKPAYICQGWGPQRQ
A
NGE
L
T
A
RAIAML
PI
LTGNVGI
S
GGNSG
-----------
A
RE
S
TYTITI
E
R
LP
V
L
D
NPVKT
S
IS
C
F
S
WTDAIDHG
PQ
MTAIR
-----
DGVR
---------
GK
D
KLDVPIKFIW
N
YAGNTL
V
NQH
S
DIN
K
THE
I
LQD
E
SKCEMIVVIE
N
FMT
S
SAKYADILLPDLM
TV
EQED
I
I
PNDY
AGNMGY
L
I
FL
QP
V
TS
E
KFERKPIYW
I
LSEVAKRLGPDVYQ
K
FTEGR
T
Q
EQ
WL
Q
H
LY
----
AK
ML
A
K
D
P
A
L
P
S
Y
D
E
L
K
KM
GI
Y
---
KRK
D
PN
G
H
F
VAY
K
AFR
D
DP
E
ANPLKTPSGKIEIYS
SK
LA
E
IA
-------
R
TWEL
E
KDE
V
I
S
PLP
V
Y
AST
F
E
GWD
S
P
E
R
R
T
F
PLQL
F
GFHYK
S
RTHS
T
YGNIDLLK
A
---
ACRQEVWINPIDAQ
K
RGIANGD
M
VRVFN
H
RGE
V
R
LP
AKVTPRILPGV
S
A
M
GQGAW
H
E
A
N
M
S
GD
K
I
DHGG
C
V
N
T
LT
T
L
RPSP
-
LAKGNP
Q
H
T
NLV
E
IEK
fig|585034.4.peg.1621
Escherichia coli IAI1 (10-807/808)
ISRR
T
L
V
K
S
T
AIGSLALA
AGG
F
S
LPF
T
--
L
R
S
AAA
T
V
-
QQ
A
S
EK
V
I
WG
A
C
S
VNCGSRCALRLHVKD
NE
V
T
WVE
T
D
N
TG
S
D
E
Y
-
GNHQVRACLRGRSIRR
-----
RINHP
----
DRL
N
YPMKRVG
T
RGEGKFERISWDEALDTI
ASS
L
K
KT
V
E
Q
YGNEAV
Y
IQ
Y
S
S
G
IV
GGN
M
T
R
S
SPS
A
SA
-
VK
RLMN
CY
GG
S
L
NQ
YGSYSTAQIS
C
AMPY
TY
GS
-----
NDGNS
T
T
DIENSKLVVMFGNNPAET
------
RMSGGG
I
TY
LL
E
K
AREKSNA
K
MIVIDPRY
T
DTAA
--
GREDEWLPIRPGTD
A
AL
VA
GIAWVLI
N
EN
L
VDQPFLDKYCVGYDEKTLPA
D
AP
K
N
G
HYKAYILGEG
D
D
N
TAKTP
Q
WA
S
Q
ITGIP
VD
R
IIKLAREIG
T
AKPAYICQGWGPQRQ
A
NGE
L
T
A
RAIAML
PI
LTGNVGI
S
GGNSG
-----------
A
RE
S
TYTITI
E
R
LP
V
L
D
NPVKT
S
IS
C
F
S
WTDAIDHG
PQ
MTAIR
-----
DGVR
---------
GK
D
KLDVPIKFIW
N
YAGNTL
V
NQH
S
DIN
K
THE
I
LQD
E
SKCEMIV
I
IE
N
FMT
S
SAKYADILLPDLM
TV
EQED
I
I
PNDY
AGNMGY
L
I
FL
QP
V
TS
E
KFERKPIYW
I
LSEVAKRLGPDVYQ
K
FTEGR
T
Q
EQ
WL
Q
H
LY
----
AK
ML
A
K
D
P
A
L
P
S
Y
D
E
L
K
KM
GI
Y
---
KRK
D
PN
G
H
F
VAY
K
AFR
D
DP
E
ANPLKTPSGKIEIYS
SR
LA
E
IA
-------
R
TWEL
E
KDE
V
I
S
PLP
V
Y
AST
F
E
GW
N
S
P
E
R
R
T
F
PLQL
F
GFHYK
S
RTHS
T
YGNIDLLK
A
---
ACRQEVWINPIDAQ
K
RGIANGD
M
VRVFN
H
RGE
V
R
LP
AKVTPRILPGV
S
A
M
GQGAW
H
E
A
N
M
S
GD
K
I
DHGG
C
V
N
T
LT
T
L
RPSP
-
LAKGNP
Q
H
T
NLV
E
IEK
fig|585034.5.peg.1616
Escherichia coli IAI1 (10-807/808)
ISRR
T
L
V
K
S
T
AIGSLALA
AGG
F
S
LPF
T
--
L
R
S
AAA
T
V
-
QQ
A
S
EK
V
I
WG
A
C
S
VNCGSRCALRLHVKD
NE
V
T
WVE
T
D
N
TG
S
D
E
Y
-
GNHQVRACLRGRSIRR
-----
RINHP
----
DRL
N
YPMKRVG
T
RGEGKFERISWDEALDTI
ASS
L
K
KT
V
E
Q
YGNEAV
Y
IQ
Y
S
S
G
IV
GGN
M
T
R
S
SPS
A
SA
-
VK
RLMN
CY
GG
S
L
NQ
YGSYSTAQIS
C
AMPY
TY
GS
-----
NDGNS
T
T
DIENSKLVVMFGNNPAET
------
RMSGGG
I
TY
LL
E
K
AREKSNA
K
MIVIDPRY
T
DTAA
--
GREDEWLPIRPGTD
A
AL
VA
GIAWVLI
N
EN
L
VDQPFLDKYCVGYDEKTLPA
D
AP
K
N
G
HYKAYILGEG
D
D
N
TAKTP
Q
WA
S
Q
ITGIP
VD
R
IIKLAREIG
T
AKPAYICQGWGPQRQ
A
NGE
L
T
A
RAIAML
PI
LTGNVGI
S
GGNSG
-----------
A
RE
S
TYTITI
E
R
LP
V
L
D
NPVKT
S
IS
C
F
S
WTDAIDHG
PQ
MTAIR
-----
DGVR
---------
GK
D
KLDVPIKFIW
N
YAGNTL
V
NQH
S
DIN
K
THE
I
LQD
E
SKCEMIV
I
IE
N
FMT
S
SAKYADILLPDLM
TV
EQED
I
I
PNDY
AGNMGY
L
I
FL
QP
V
TS
E
KFERKPIYW
I
LSEVAKRLGPDVYQ
K
FTEGR
T
Q
EQ
WL
Q
H
LY
----
AK
ML
A
K
D
P
A
L
P
S
Y
D
E
L
K
KM
GI
Y
---
KRK
D
PN
G
H
F
VAY
K
AFR
D
DP
E
ANPLKTPSGKIEIYS
SR
LA
E
IA
-------
R
TWEL
E
KDE
V
I
S
PLP
V
Y
AST
F
E
GW
N
S
P
E
R
R
T
F
PLQL
F
GFHYK
S
RTHS
T
YGNIDLLK
A
---
ACRQEVWINPIDAQ
K
RGIANGD
M
VRVFN
H
RGE
V
R
LP
AKVTPRILPGV
S
A
M
GQGAW
H
E
A
N
M
S
GD
K
I
DHGG
C
V
N
T
LT
T
L
RPSP
-
LAKGNP
Q
H
T
NLV
E
IEK
fig|595495.4.peg.2853
Escherichia coli KO11 (10-807/808)
ISRR
T
L
V
K
S
T
AIGSLALA
AGG
F
S
LPF
T
--
L
R
S
AAA
A
V
-
QQ
A
R
EK
V
VWG
A
C
S
VNCGSRCALRLHVKD
NE
V
T
WVE
T
D
N
TG
S
D
E
Y
-
GNHQVRACLRGRSIRR
-----
RINHP
----
DRL
N
YPMKRVGKRGEGKFERISWDEALDTI
ASS
L
K
KT
V
E
Q
YGNEAV
Y
IQ
Y
S
S
G
IV
GGN
M
T
R
S
SPS
A
SA
-
VK
RLMN
CY
GG
S
L
NQ
YGSYSTAQIS
C
AMPY
TY
GS
-----
NDGNS
T
T
DIENSKLVVMFGNNPAET
------
RMSGGG
I
TY
LL
E
K
AREKSNA
K
MIVIDPRY
T
DTAA
--
GREDEWLPIRPGTD
A
AL
VA
GIAWVLI
N
EN
L
VDQPFLDKYCVGYDEKTLPA
D
AP
K
N
G
HYKAYILGEG
D
D
N
TAKTP
Q
WA
S
Q
ITGIP
VD
R
IIKLAREIG
T
AKPAYICQGWGPQRQ
A
NGE
L
T
A
RAIAML
PI
LTGNVGI
S
GGNSG
-----------
A
RE
S
TYTITI
E
R
LP
V
L
D
NPVKT
S
IS
C
F
S
WTDAIDHG
PQ
MTAIR
-----
DGVR
---------
GK
D
KLDVPIKFIW
N
YAGNTL
V
NQH
S
DIN
K
THE
I
LQD
E
SKCEMIV
I
IE
N
FMT
S
SAKYADILLPDLM
TV
EQED
I
I
PNDY
AGNMGY
L
I
FL
QP
V
TS
E
KFERKPIYW
I
LSEVAKRLGPDVYQ
K
FTEGR
T
Q
EQ
WL
Q
H
LY
----
AK
ML
A
K
D
P
A
L
P
S
Y
D
E
L
K
KM
GI
Y
---
KRK
D
PN
G
H
F
VAY
K
AFR
D
DP
E
ANPLKTPSGKIEIYS
SR
LA
E
IA
-------
R
TWEL
E
KDE
V
I
S
PLP
V
Y
AST
F
E
GW
N
S
P
E
R
R
T
F
PLQL
F
GFHYK
S
RTHS
T
YGNIDLLK
A
---
ACRQEVWINPIDAQ
K
RGIANGD
M
VRVFN
H
RGE
V
R
LP
AKVTPRILPGV
S
A
M
GQGAW
H
E
A
N
M
S
GD
K
I
DHGG
C
V
N
T
LT
T
L
RPSP
-
LAKGNP
Q
H
T
NLV
E
IEK
fig|566546.3.peg.1066
Escherichia coli W (10-807/808)
ISRR
T
L
V
K
S
T
AIGSLALA
AGG
F
S
LPF
T
--
L
R
S
AAA
A
V
-
QQ
A
R
EK
V
VWG
A
C
S
VNCGSRCALRLHVKD
NE
V
T
WVE
T
D
N
TG
S
D
E
Y
-
GNHQVRACLRGRSIRR
-----
RINHP
----
DRL
N
YPMKRVGKRGEGKFERISWDEALDTI
ASS
L
K
KT
V
E
Q
YGNEAV
Y
IQ
Y
S
S
G
IV
GGN
M
T
R
S
SPS
A
SA
-
VK
RLMN
CY
GG
S
L
NQ
YGSYSTAQIS
C
AMPY
TY
GS
-----
NDGNS
T
T
DIENSKLVVMFGNNPAET
------
RMSGGG
I
TY
LL
E
K
AREKSNA
K
MIVIDPRY
T
DTAA
--
GREDEWLPIRPGTD
A
AL
VA
GIAWVLI
N
EN
L
VDQPFLDKYCVGYDEKTLPA
D
AP
K
N
G
HYKAYILGEG
D
D
N
TAKTP
Q
WA
S
Q
ITGIP
VD
R
IIKLAREIG
T
AKPAYICQGWGPQRQ
A
NGE
L
T
A
RAIAML
PI
LTGNVGI
S
GGNSG
-----------
A
RE
S
TYTITI
E
R
LP
V
L
D
NPVKT
S
IS
C
F
S
WTDAIDHG
PQ
MTAIR
-----
DGVR
---------
GK
D
KLDVPIKFIW
N
YAGNTL
V
NQH
S
DIN
K
THE
I
LQD
E
SKCEMIV
I
IE
N
FMT
S
SAKYADILLPDLM
TV
EQED
I
I
PNDY
AGNMGY
L
I
FL
QP
V
TS
E
KFERKPIYW
I
LSEVAKRLGPDVYQ
K
FTEGR
T
Q
EQ
WL
Q
H
LY
----
AK
ML
A
K
D
P
A
L
P
S
Y
D
E
L
K
KM
GI
Y
---
KRK
D
PN
G
H
F
VAY
K
AFR
D
DP
E
ANPLKTPSGKIEIYS
SR
LA
E
IA
-------
R
TWEL
E
KDE
V
I
S
PLP
V
Y
AST
F
E
GW
N
S
P
E
R
R
T
F
PLQL
F
GFHYK
S
RTHS
T
YGNIDLLK
A
---
ACRQEVWINPIDAQ
K
RGIANGD
M
VRVFN
H
RGE
V
R
LP
AKVTPRILPGV
S
A
M
GQGAW
H
E
A
N
M
S
GD
K
I
DHGG
C
V
N
T
LT
T
L
RPSP
-
LAKGNP
Q
H
T
NLV
E
IEK
fig|566546.4.peg.1739
Escherichia coli W (10-807/808)
ISRR
T
L
V
K
S
T
AIGSLALA
AGG
F
S
LPF
T
--
L
R
S
AAA
A
V
-
QQ
A
R
EK
V
VWG
A
C
S
VNCGSRCALRLHVKD
NE
V
T
WVE
T
D
N
TG
S
D
E
Y
-
GNHQVRACLRGRSIRR
-----
RINHP
----
DRL
N
YPMKRVGKRGEGKFERISWDEALDTI
ASS
L
K
KT
V
E
Q
YGNEAV
Y
IQ
Y
S
S
G
IV
GGN
M
T
R
S
SPS
A
SA
-
VK
RLMN
CY
GG
S
L
NQ
YGSYSTAQIS
C
AMPY
TY
GS
-----
NDGNS
T
T
DIENSKLVVMFGNNPAET
------
RMSGGG
I
TY
LL
E
K
AREKSNA
K
MIVIDPRY
T
DTAA
--
GREDEWLPIRPGTD
A
AL
VA
GIAWVLI
N
EN
L
VDQPFLDKYCVGYDEKTLPA
D
AP
K
N
G
HYKAYILGEG
D
D
N
TAKTP
Q
WA
S
Q
ITGIP
VD
R
IIKLAREIG
T
AKPAYICQGWGPQRQ
A
NGE
L
T
A
RAIAML
PI
LTGNVGI
S
GGNSG
-----------
A
RE
S
TYTITI
E
R
LP
V
L
D
NPVKT
S
IS
C
F
S
WTDAIDHG
PQ
MTAIR
-----
DGVR
---------
GK
D
KLDVPIKFIW
N
YAGNTL
V
NQH
S
DIN
K
THE
I
LQD
E
SKCEMIV
I
IE
N
FMT
S
SAKYADILLPDLM
TV
EQED
I
I
PNDY
AGNMGY
L
I
FL
QP
V
TS
E
KFERKPIYW
I
LSEVAKRLGPDVYQ
K
FTEGR
T
Q
EQ
WL
Q
H
LY
----
AK
ML
A
K
D
P
A
L
P
S
Y
D
E
L
K
KM
GI
Y
---
KRK
D
PN
G
H
F
VAY
K
AFR
D
DP
E
ANPLKTPSGKIEIYS
SR
LA
E
IA
-------
R
TWEL
E
KDE
V
I
S
PLP
V
Y
AST
F
E
GW
N
S
P
E
R
R
T
F
PLQL
F
GFHYK
S
RTHS
T
YGNIDLLK
A
---
ACRQEVWINPIDAQ
K
RGIANGD
M
VRVFN
H
RGE
V
R
LP
AKVTPRILPGV
S
A
M
GQGAW
H
E
A
N
M
S
GD
K
I
DHGG
C
V
N
T
LT
T
L
RPSP
-
LAKGNP
Q
H
T
NLV
E
IEK
fig|481805.3.peg.2201
Escherichia coli ATCC 8739 (10-807/808)
ISRR
T
L
V
K
S
T
AIGSLALA
AGG
F
S
LPF
T
--
L
R
N
AAA
S
V
-
QQ
A
R
EK
V
VWG
A
C
S
VNCGSRCALRLHVKD
NE
V
T
WVE
T
D
N
TG
S
D
E
Y
-
GNHQVRACLRGRSIRR
-----
RINHP
----
DRL
N
YPMKRVGKRGEGKFERISWDEALDTI
ASS
L
K
KT
V
E
Q
YGNEAV
Y
IQ
Y
S
S
G
IV
GGN
M
T
R
S
SPS
A
SA
-
VK
RLMN
CY
GG
S
L
NQ
YGSYSTAQIS
C
AMPY
TY
GS
-----
NDGNS
T
T
DIENSKLVVMFGNNPAET
------
RMSGGG
I
TY
LL
E
K
AREKSNA
K
MIVIDPRY
T
DTAA
--
GREDEWLPIRPGTD
A
AL
VA
GIAWVLI
N
EN
L
VDQPFLDKYCVGYDEKTLPA
D
AP
K
N
G
HYKAYILGEG
D
D
K
TAKTP
Q
WA
S
Q
ITGIP
ED
R
IIKLAREIG
T
AKPAYICQGWGPQRQ
A
NGE
L
T
A
RAIAML
PI
LTGNVGI
S
GGNSG
-----------
A
RE
S
TYTITI
E
R
LP
V
L
D
NPVKT
S
IS
C
F
S
WTDAIDHG
PQ
MTAIR
-----
DGVR
---------
GK
D
KLDVPIKFIW
N
YAGNTL
V
NQH
S
DIN
K
THE
I
LQD
E
SKCEMIVVIE
N
FMT
S
SAKYADILLPDLM
TV
EQED
I
I
PNDY
AGNMGY
L
I
FL
QP
V
TS
E
KFERKPIYW
I
LSEVAKRLGPDVYQ
K
FTEGR
T
Q
EQ
WL
Q
H
LY
----
AK
ML
A
K
D
P
A
L
P
S
Y
D
E
L
K
KM
GI
Y
---
KRK
D
PN
G
H
F
VAY
K
AFR
D
DP
E
ANPLKTPSGKIEIYS
SR
LA
E
IA
-------
R
TWEL
E
KDE
V
I
S
PLP
V
Y
AST
F
E
GW
N
S
P
E
R
R
T
F
PLQL
F
GFHYK
S
RTHS
T
YGNIDLLK
A
---
ACRQEVWINPIDAQ
K
RGIANGD
M
VRVFN
H
RGE
V
R
LP
AKVTPRILPGV
S
A
M
GQGAW
H
E
A
N
M
S
GD
K
I
DHGG
C
V
N
T
LT
T
L
RPSP
-
LAKGNP
Q
H
T
NLV
E
IEK
fig|481805.6.peg.2194
Escherichia coli ATCC 8739 (10-807/808)
ISRR
T
L
V
K
S
T
AIGSLALA
AGG
F
S
LPF
T
--
L
R
N
AAA
S
V
-
QQ
A
R
EK
V
VWG
A
C
S
VNCGSRCALRLHVKD
NE
V
T
WVE
T
D
N
TG
S
D
E
Y
-
GNHQVRACLRGRSIRR
-----
RINHP
----
DRL
N
YPMKRVGKRGEGKFERISWDEALDTI
ASS
L
K
KT
V
E
Q
YGNEAV
Y
IQ
Y
S
S
G
IV
GGN
M
T
R
S
SPS
A
SA
-
VK
RLMN
CY
GG
S
L
NQ
YGSYSTAQIS
C
AMPY
TY
GS
-----
NDGNS
T
T
DIENSKLVVMFGNNPAET
------
RMSGGG
I
TY
LL
E
K
AREKSNA
K
MIVIDPRY
T
DTAA
--
GREDEWLPIRPGTD
A
AL
VA
GIAWVLI
N
EN
L
VDQPFLDKYCVGYDEKTLPA
D
AP
K
N
G
HYKAYILGEG
D
D
K
TAKTP
Q
WA
S
Q
ITGIP
ED
R
IIKLAREIG
T
AKPAYICQGWGPQRQ
A
NGE
L
T
A
RAIAML
PI
LTGNVGI
S
GGNSG
-----------
A
RE
S
TYTITI
E
R
LP
V
L
D
NPVKT
S
IS
C
F
S
WTDAIDHG
PQ
MTAIR
-----
DGVR
---------
GK
D
KLDVPIKFIW
N
YAGNTL
V
NQH
S
DIN
K
THE
I
LQD
E
SKCEMIVVIE
N
FMT
S
SAKYADILLPDLM
TV
EQED
I
I
PNDY
AGNMGY
L
I
FL
QP
V
TS
E
KFERKPIYW
I
LSEVAKRLGPDVYQ
K
FTEGR
T
Q
EQ
WL
Q
H
LY
----
AK
ML
A
K
D
P
A
L
P
S
Y
D
E
L
K
KM
GI
Y
---
KRK
D
PN
G
H
F
VAY
K
AFR
D
DP
E
ANPLKTPSGKIEIYS
SR
LA
E
IA
-------
R
TWEL
E
KDE
V
I
S
PLP
V
Y
AST
F
E
GW
N
S
P
E
R
R
T
F
PLQL
F
GFHYK
S
RTHS
T
YGNIDLLK
A
---
ACRQEVWINPIDAQ
K
RGIANGD
M
VRVFN
H
RGE
V
R
LP
AKVTPRILPGV
S
A
M
GQGAW
H
E
A
N
M
S
GD
K
I
DHGG
C
V
N
T
LT
T
L
RPSP
-
LAKGNP
Q
H
T
NLV
E
IEK
fig|656440.3.peg.4366
Escherichia coli TA206 (10-807/808)
ISRR
T
L
V
K
S
T
AIGSLALA
AGG
F
S
LPF
T
--
L
R
S
AAA
A
V
-
QQ
A
N
EK
V
VWG
A
C
S
VNCGSRCALRLHVKD
NE
V
T
WVE
T
D
N
TG
N
D
E
Y
-
GNHQVRACLRGRSIRR
-----
RINHP
----
DRL
N
YPMKRVGKRGEGKFERISWDEALDTI
ASS
L
K
KT
V
E
Q
YGNEAV
Y
IQ
Y
S
S
G
IV
GGN
M
T
R
S
SPS
A
SA
-
VK
RLMN
CY
GG
S
L
NQ
YGSYSTAQIS
C
AMPY
TY
GS
-----
NDGNS
T
T
DIENSKLVVMFGNNPAET
------
RMSGGG
I
TY
LL
E
K
AREKSNA
K
MIVIDPRY
T
DTAA
--
GREDEWLPIRPGTD
A
AL
VA
GIAWVLI
N
EN
L
VDQPFLDKYCVGYDEKTLPA
D
AP
K
N
G
HYKAYILGEG
D
D
K
TAKTP
Q
WA
S
Q
ITGIP
ED
R
IIKLAREIG
T
AKPAYICQGWGPQRQ
A
NGE
L
T
A
RAIAML
PI
LTGNVGI
S
GGNSG
-----------
A
RE
S
TYTITI
E
R
LP
V
L
D
NPVKT
S
IS
C
F
S
WTDAIDHG
PQ
MTAIR
-----
DGVR
---------
GK
D
KLDVPIKFIW
N
YAGNTL
V
NQH
S
DIN
K
THE
I
LQD
E
SKCEMIVVIE
N
FMT
S
SAKYADILLPDLM
TV
EQED
I
I
PNDY
AGNMGY
L
I
FL
QP
V
TS
E
KFERKPIYWVLSEVAKRLGPDVYQ
K
FTEGR
T
Q
EQ
WL
Q
H
LY
----
AK
ML
A
K
D
P
A
L
P
S
Y
D
E
L
K
KM
GI
Y
---
KRK
D
PN
G
H
F
VAY
K
AFR
D
DP
E
ANPLKTPSGKIEIYS
SK
LA
E
IA
-------
R
TWEL
E
KDE
V
I
S
PLP
V
Y
AST
F
E
GWD
S
P
E
R
SI
F
PLQL
F
GFHYK
S
R
A
HS
T
YGNID
V
LK
A
---
ACRQEVWINPIDAQ
K
RGIANGD
M
VRVFN
H
RGE
V
R
LP
AKVTPRILPGV
S
A
M
GQGAW
H
E
A
N
M
S
GD
K
I
DHGG
C
V
N
T
LT
T
L
RPSP
-
LAKGNP
Q
H
T
NLV
E
IEK
fig|550672.3.peg.2427
Escherichia coli B088 (10-807/808)
ISRR
T
L
V
K
S
T
AIGSLALA
AGG
F
S
LPF
T
--
L
R
S
AAA
T
V
-
QQ
A
S
EK
V
I
WG
A
C
S
VNCGSRCALRLHVKD
NE
V
T
WVE
T
D
N
TG
S
D
E
Y
-
GNHQVRACLRGRSIRR
-----
RINHP
----
DRL
N
YPMKRVG
T
RGEGKFERISWDEALDTI
ASS
L
K
KT
V
E
Q
YGNEAV
Y
IQ
Y
S
S
G
IV
GGN
M
T
R
S
SPS
A
SA
-
VK
RLMN
CY
GG
S
L
NQ
YGSYSTAQIS
C
AMPY
TY
GS
-----
NDGNS
T
T
DIENSKLVVMFGNNPAET
------
RMSGGG
I
TY
LL
E
K
AREKSNA
K
MIVIDPRY
T
DTAA
--
GREDEWLPIRPGTD
A
AL
VA
GIAWVLI
N
EN
L
VDQPFLDKYCVGYDEKTLPA
D
AP
K
N
G
HYKAYILGEG
D
D
N
TAKTP
Q
WA
S
Q
ITGIP
VD
R
IIKLAREIG
T
AKPAYICQGWGPQRQ
A
NGE
L
T
A
RAIAML
PI
LTGNVGI
S
GGNSG
-----------
A
RE
S
TYTITI
E
R
LP
V
L
D
NPVKT
S
IS
C
F
S
WTDAIDHG
PQ
MTAIR
-----
DGVR
---------
GK
D
KLDVPIKFIW
N
YAGNTL
V
NQH
S
DIN
K
THE
I
LQD
E
SKCEMIVVIE
N
FMT
S
SAKYADILLPDLM
TV
EQED
I
I
PNDY
AGNMGY
L
I
FL
QP
V
TS
E
KFERKPIYW
I
LSEVAKRLGPDVYQ
K
FTEGR
T
Q
EQ
WL
Q
H
LY
----
AK
ML
A
K
D
P
A
L
P
S
Y
D
E
L
K
KM
GI
Y
---
KRK
D
PN
G
H
F
VAY
K
AFR
D
DP
E
ANPLKTPSGKIEIYS
SR
LA
E
IA
-------
R
TWEL
E
KDE
V
I
S
PLP
V
Y
AST
F
E
GW
N
S
P
E
R
R
T
F
PLQL
F
GFHYK
S
RTHS
T
YGNID
V
LK
A
---
ACRQEVWINPIDAQ
K
RGIANGD
M
VRVFN
H
RGE
V
R
LP
AKVTPRILPGV
S
A
M
GQGAW
H
E
A
N
M
S
GD
K
I
DHGG
C
V
N
T
LT
T
L
RPSP
-
LAKGNP
Q
H
T
NLV
E
IEK
fig|340184.3.peg.1015
Escherichia coli B7A (10-807/808)
ISRR
T
L
V
K
S
T
AIGSLALA
AGG
F
S
LPF
T
--
L
R
S
AAA
A
V
-
QQ
A
R
EK
V
VWG
A
C
S
VNCGSRCALRLHVKD
NE
V
T
WVE
T
D
N
TG
S
D
E
Y
-
GNHQVRACLRGRSIRR
-----
RINHP
----
DRL
N
YPMKRVGKRGEGKFERISWDEALDTI
ASS
L
K
KT
V
E
Q
YGNEAV
Y
IQ
Y
S
S
G
IV
GGN
M
T
R
S
SPS
A
SA
-
VK
RLMN
CY
GG
S
L
NQ
YGSYSTAQIS
C
AMPY
TY
GS
-----
NDGNS
T
T
DIENSKLVVMFGNNPAET
------
RMSGGG
I
TY
LL
E
K
AREKSNA
K
MIVIDPRY
T
DTAA
--
GREDEWLPIRPGTD
A
AL
VA
GIAWVLI
N
EN
L
VDQPFLDKYCVGYDEKTLPA
D
AP
K
N
G
HYKAYILGEG
D
D
N
TAKTP
Q
WA
S
Q
ITGIP
VD
R
IIKLAREIG
T
AKPAYICQGWGPQRQ
A
NGE
L
T
A
RAIAML
PI
LTGNVGI
S
GGNSG
-----------
A
RE
S
TYTITI
E
R
LP
V
L
D
NPVKT
S
IS
C
F
S
WTDAIDHG
PQ
MTAIR
-----
DGVR
---------
GK
D
KLDVPIKFIW
N
YAGNTL
V
NQH
S
DIN
K
THE
I
LQD
E
SKCEMIVVIE
N
FMT
S
SAKYADILLPDLM
TV
EQED
I
I
PNDY
AGNMGY
L
I
FL
QP
V
TS
E
KFERKPIYW
I
LSEVAKRLGPDVYQ
K
FTEGR
T
Q
EQ
WL
Q
H
LY
----
AK
ML
A
K
D
P
A
L
P
S
Y
D
E
L
K
KM
GI
Y
---
KRK
D
PN
G
H
F
VAY
K
AFR
D
DP
E
ANPLKTPSGKIEIYS
SK
LA
E
IA
-------
R
TWEL
E
KDE
V
I
S
PLP
V
Y
AST
F
E
GWD
S
P
E
R
R
T
F
PLQL
F
GFHYK
S
RTHS
T
YGNID
V
LK
A
---
ACRQEVWINPIDAQ
K
RGIANGD
M
VRVFN
H
RGE
V
R
LP
AKVTPRILPGV
S
A
M
GQGAW
H
E
A
N
M
S
GD
K
I
DHGG
C
V
N
T
LT
T
L
RPSP
-
LAKGNP
Q
H
T
NLV
E
IEK
fig|340184.6.peg.1050
Escherichia coli B7A (10-807/808)
ISRR
T
L
V
K
S
T
AIGSLALA
AGG
F
S
LPF
T
--
L
R
S
AAA
A
V
-
QQ
A
R
EK
V
VWG
A
C
S
VNCGSRCALRLHVKD
NE
V
T
WVE
T
D
N
TG
S
D
E
Y
-
GNHQVRACLRGRSIRR
-----
RINHP
----
DRL
N
YPMKRVGKRGEGKFERISWDEALDTI
ASS
L
K
KT
V
E
Q
YGNEAV
Y
IQ
Y
S
S
G
IV
GGN
M
T
R
S
SPS
A
SA
-
VK
RLMN
CY
GG
S
L
NQ
YGSYSTAQIS
C
AMPY
TY
GS
-----
NDGNS
T
T
DIENSKLVVMFGNNPAET
------
RMSGGG
I
TY
LL
E
K
AREKSNA
K
MIVIDPRY
T
DTAA
--
GREDEWLPIRPGTD
A
AL
VA
GIAWVLI
N
EN
L
VDQPFLDKYCVGYDEKTLPA
D
AP
K
N
G
HYKAYILGEG
D
D
N
TAKTP
Q
WA
S
Q
ITGIP
VD
R
IIKLAREIG
T
AKPAYICQGWGPQRQ
A
NGE
L
T
A
RAIAML
PI
LTGNVGI
S
GGNSG
-----------
A
RE
S
TYTITI
E
R
LP
V
L
D
NPVKT
S
IS
C
F
S
WTDAIDHG
PQ
MTAIR
-----
DGVR
---------
GK
D
KLDVPIKFIW
N
YAGNTL
V
NQH
S
DIN
K
THE
I
LQD
E
SKCEMIVVIE
N
FMT
S
SAKYADILLPDLM
TV
EQED
I
I
PNDY
AGNMGY
L
I
FL
QP
V
TS
E
KFERKPIYW
I
LSEVAKRLGPDVYQ
K
FTEGR
T
Q
EQ
WL
Q
H
LY
----
AK
ML
A
K
D
P
A
L
P
S
Y
D
E
L
K
KM
GI
Y
---
KRK
D
PN
G
H
F
VAY
K
AFR
D
DP
E
ANPLKTPSGKIEIYS
SK
LA
E
IA
-------
R
TWEL
E
KDE
V
I
S
PLP
V
Y
AST
F
E
GWD
S
P
E
R
R
T
F
PLQL
F
GFHYK
S
RTHS
T
YGNID
V
LK
A
---
ACRQEVWINPIDAQ
K
RGIANGD
M
VRVFN
H
RGE
V
R
LP
AKVTPRILPGV
S
A
M
GQGAW
H
E
A
N
M
S
GD
K
I
DHGG
C
V
N
T
LT
T
L
RPSP
-
LAKGNP
Q
H
T
NLV
E
IEK
fig|679204.3.peg.504
Escherichia coli MS 145-7 (10-807/808)
ISRR
T
L
V
K
S
T
AIGSLALA
AGG
F
S
LPF
T
--
L
R
S
AAA
A
V
-
QQ
A
R
EK
V
VWG
A
C
S
VNCGSRCALRLHVKD
NE
V
T
WVE
T
D
N
TG
S
D
E
Y
-
GNHQVRACLRGRSIRR
-----
RINHP
----
DRL
N
YPMKRVGKRGEGKFERISWDEALDTI
ASS
L
K
KT
V
E
Q
YGNEAV
Y
IQ
Y
S
S
G
IV
GGN
M
T
R
S
SPS
A
SA
-
VK
RLMN
CY
GG
S
L
NQ
YGSYSTAQIS
C
AMPY
TY
GS
-----
NDGNS
T
T
DIENSKLVVMFGNNPAET
------
RMSGGG
I
TY
LL
E
K
AREKSNA
K
MIVIDPRY
T
DTAA
--
GREDEWLPIRPGTD
A
AL
VA
GIAWVLI
N
EN
L
VDQPFLDKYCVGYDEKTLPA
D
AP
K
N
G
HYKAYILGEG
D
D
N
TAKTP
Q
WA
S
Q
ITGIP
VD
R
IIKLAREIG
T
AKPAYICQGWGPQRQ
A
NGE
L
T
A
RAIAML
PI
LTGNVGI
S
GGNSG
-----------
A
RE
S
TYTITI
E
R
LP
V
L
D
NPVKT
S
IS
C
F
S
WTDAIDHG
PQ
MTAIR
-----
DGVR
---------
GK
D
KLDVPIKFIW
N
YAGNTL
V
NQH
S
DIN
K
THE
I
LQD
E
SKCEMIVVIE
N
FMT
S
SAKYADILLPDLM
TV
EQED
I
I
PNDY
AGNMGY
L
I
FL
QP
V
TS
E
KFERKPIYW
I
LSEVAKRLGPDVYQ
K
FTEGR
T
Q
EQ
WL
Q
H
LY
----
AK
ML
A
K
D
P
A
L
P
S
Y
D
E
L
K
KM
GI
Y
---
KRK
D
PN
G
H
F
VAY
K
AFR
D
DP
E
ANPLKTPSGKIEIYS
SK
LA
E
IA
-------
R
TWEL
E
KDE
V
I
S
PLP
V
Y
AST
F
E
GWD
S
P
E
R
R
T
F
PLQL
F
GFHYK
S
RTHS
T
YGNID
V
LK
A
---
ACRQEVWINPIDAQ
K
RGIANGD
M
VRVFN
H
RGE
V
R
LP
AKVTPRILPGV
S
A
M
GQGAW
H
E
A
N
M
S
GD
K
I
DHGG
C
V
N
T
LT
T
L
RPSP
-
LAKGNP
Q
H
T
NLV
E
IEK
fig|679205.4.peg.1617
Escherichia coli MS 124-1 (10-807/808)
ISRR
T
L
V
K
S
T
AIGSLALA
AGG
F
S
LPF
T
--
L
R
S
AAA
T
V
-
QQ
A
S
EK
V
I
WG
A
C
S
VNCGSRCALRLHVKD
NE
V
T
WVE
T
D
N
TG
S
D
E
Y
-
GNHQVRACLRGRSIRR
-----
RINHP
----
DRL
N
YPMKRVG
T
RGEGKFERISWDEALDTI
ASS
L
K
KT
V
E
Q
YGNEAV
Y
IQ
Y
S
S
G
IV
GGN
M
T
R
S
SPS
A
SA
-
VK
RLMN
CY
GG
S
L
NQ
YGSYSTAQIS
C
AMPY
TY
GS
-----
NDGNS
T
T
DIENSKLVVMFGNNPAET
------
RMSGGG
I
TY
LL
E
K
AREKSNA
K
MIVIDPRY
T
DTAA
--
GREDEWLPIRPGTD
A
AL
VA
GIAWVLI
N
EN
L
VDQPFLDKYCVGYDEKTLPA
D
AP
K
N
G
HYKAYILGEG
D
D
N
TAKTP
Q
WA
S
Q
ITGIP
VD
R
IIKLAREIG
T
AKPAYICQGWGPQRQ
A
NGE
L
T
A
RAIAML
PI
LTGNVGI
S
GGNSG
-----------
A
RE
S
TYTITI
E
R
LP
V
L
D
NPVKT
S
IS
C
F
S
WTDAIDHG
PQ
MTAIR
-----
DGVR
---------
GK
D
KLDVPIKFIW
N
YAGNTL
V
NQH
S
DIN
K
THE
I
LQD
E
SKCEMIVVIE
N
FMT
S
SAKYADILLPDLM
TV
EQED
I
I
PNDY
AGNMGY
L
I
FL
QP
V
TS
E
KFERKPIYW
I
LSEVAKRLGPDVYQ
K
FTEGR
T
Q
EQ
WL
Q
H
LY
----
AK
ML
A
K
D
P
A
L
P
S
Y
D
E
L
K
KM
GI
Y
---
KRK
D
PN
G
H
F
VAY
K
AFR
D
DP
E
ANPLKTPSGKIEIYS
SK
LA
E
IA
-------
R
TWEL
E
KDE
V
I
S
PLP
V
Y
AST
F
E
GWD
S
P
E
R
S
T
F
PLQL
F
GFHYK
S
RTHS
T
YGNID
V
LK
A
---
ACRQEVWINPIDAQ
K
RGIANGD
M
VRVFN
H
RGE
V
R
LP
AKVTPRILPGV
S
A
M
GQGAW
H
E
A
N
I
S
GD
K
I
DHGG
C
V
N
T
LT
T
L
RPSP
-
LAKGNP
Q
H
T
NLV
E
IEK
fig|749533.3.peg.4939
Escherichia coli MS 84-1 (10-807/808)
ISRR
T
L
V
K
S
T
AIGSLALA
AGG
F
S
LPF
T
--
L
R
S
AAA
T
V
-
QQ
A
S
EK
V
I
WG
A
C
S
VNCGSRCALRLHVKD
NE
V
T
WVE
T
D
N
TG
S
D
E
Y
-
GNHQVRACLRGRSIRR
-----
RINHP
----
DRL
N
YPMKRVG
T
RGEGKFERISWDEALDTI
ASS
L
K
KT
V
E
Q
YGNEAV
Y
IQ
Y
S
S
G
IV
GGN
M
T
R
S
SPS
A
SA
-
VK
RLMN
CY
GG
S
L
NQ
YGSYSTAQIS
C
AMPY
TY
GS
-----
NDGNS
T
T
DIENSKLVVMFGNNPAET
------
RMSGGG
I
TY
LL
E
K
AREKSNA
K
MIVIDPRY
T
DTAA
--
GREDEWLPIRPGTD
A
AL
VA
GIAWVLI
N
EN
L
VDQPFLDKYCVGYDEKTLPA
D
AP
K
N
G
HYKAYILGEG
D
D
N
TAKTP
Q
WA
S
Q
ITGIP
VD
R
IIKLAREIG
T
AKPAYICQGWGPQRQ
A
NGE
L
T
A
RAIAML
PI
LTGNVGI
S
GGNSG
-----------
A
RE
S
TYTITI
E
R
LP
V
L
D
NPVKT
S
IS
C
F
S
WTDAIDHG
PQ
MTAIR
-----
DGVR
---------
GK
D
KLDVPIKFIW
N
YAGNTL
V
NQH
S
DIN
K
THE
I
LQD
E
SKCEMIVVIE
N
FMT
S
SAKYADILLPDLM
TV
EQED
I
I
PNDY
AGNMGY
L
I
FL
QP
V
TS
E
KFERKPIYW
I
LSEVAKRLGPDVYQ
K
FTEGR
T
Q
EQ
WL
Q
H
LY
----
AK
ML
A
K
D
P
A
L
P
S
Y
D
E
L
K
KM
GI
Y
---
KRK
D
PN
G
H
F
VAY
K
AFR
D
DP
E
ANPLKTPSGKIEIYS
SK
LA
E
IA
-------
R
TWEL
E
KDE
V
I
S
PLP
V
Y
AST
F
E
GWD
S
P
E
R
S
T
F
PLQL
F
GFHYK
S
RTHS
T
YGNID
V
LK
A
---
ACRQEVWINPIDAQ
K
RGIANGD
M
VRVFN
H
RGE
V
R
LP
AKVTPRILPGV
S
A
M
GQGAW
H
E
A
N
I
S
GD
K
I
DHGG
C
V
N
T
LT
T
L
RPSP
-
LAKGNP
Q
H
T
NLV
E
IEK
fig|585395.4.peg.1810
Escherichia coli O103:H2 str. 12009 (10-807/808)
ISRR
T
L
V
K
S
T
AIGSLALA
AGG
F
S
LPF
T
--
L
R
S
AAA
A
V
-
QQ
A
R
EK
V
VWG
A
C
S
VNCGSRCALRLHVKD
NE
V
T
WVE
T
D
N
TG
S
D
E
Y
-
GNHQVRACLRGRSIRR
-----
RINHP
----
DRL
N
YPMKRVGKRGEGKFERISWDEALDTI
ASS
L
K
KT
V
E
Q
YGNEAV
Y
IQ
Y
S
S
G
IV
GGN
M
T
R
S
SPS
A
SA
-
VK
RLMN
CY
GG
S
L
NQ
YGSYSTAQIS
C
AMPY
TY
GS
-----
NDGNS
T
T
DIENSKLVVMFGNNPAET
------
RMSGGG
I
TY
LL
E
K
AREKSNA
K
MIVIDPRY
T
DTAA
--
GREDEWLPIRPGTD
A
AL
VA
GIAWVLI
N
EN
L
VDQPFLDKYCVGYDEKTLPA
D
AP
K
N
G
HYKAYILGEG
D
D
N
TAKTP
Q
WA
S
Q
ITGIP
VD
R
IIKLAREIG
T
AKPAYICQGWGPQRQ
A
NGE
L
T
A
RAIAML
PI
LTGNVGI
S
GGNSG
-----------
A
RE
S
TYTITI
E
R
LP
V
L
D
NPVKT
S
IS
C
F
S
WTDAIDHG
PQ
MTAIR
-----
DGVR
---------
GK
D
KLDVPIKFIW
N
YAGNTL
V
NQH
S
DIN
K
THE
I
LQD
E
SKCEMIVVIE
N
FMT
S
SAKYADILLPDLM
TV
EQED
I
I
PNDY
AGNMGY
L
I
FL
QP
V
TS
E
KFERKPIYW
I
LSEVAKRLGPDVYQ
K
FTEGR
T
Q
EQ
WL
Q
H
LY
----
AK
ML
A
K
D
P
A
L
P
S
Y
D
E
L
K
KM
GI
Y
---
KRK
D
PN
G
H
F
VAY
K
AFR
D
DP
E
ANPLKTPSGKIEIYS
SR
LA
E
IA
-------
R
TWEL
E
KDE
V
I
S
PLP
V
Y
AST
F
E
GW
N
S
P
E
R
S
T
F
PLQL
F
GFHYK
S
RTHS
T
YGNID
V
LK
A
---
ACRQEVWINPIDAQ
K
RGIANGD
M
VRVFN
H
RGE
V
R
LP
AKVTPRILPGV
S
A
M
GQGAW
H
E
A
N
M
S
GD
K
I
DHGG
C
V
N
T
LT
T
L
RPSP
-
LAKGNP
Q
H
T
NLV
E
IEK
fig|344601.3.peg.331
Escherichia coli B171 (10-807/808)
ISRR
T
L
V
K
S
T
AIGSLALA
AGG
F
S
LPF
T
--
L
R
S
AAA
A
V
-
QQ
A
R
EK
V
VWG
A
C
S
VNCGSRCALRLHVKD
NE
V
T
WVE
T
D
N
TG
S
D
E
Y
-
GNHQVRACLRGRSIRR
-----
RINHP
----
DRL
N
YPMKRVGKRGEGKFERISWDEALDTI
ASS
L
K
KT
V
E
Q
YGNEAV
Y
IQ
Y
S
S
G
IV
GGN
M
T
R
S
SPS
A
SA
-
VK
RLMN
CY
GG
S
L
NQ
YGSYSTAQIS
C
AMPY
TY
GS
-----
NDGNS
T
T
DIENSKLVVMFGNNPAET
------
RMSGGG
I
TY
LL
E
K
AREKSNA
K
MIVIDPRY
T
DTAA
--
GREDEWLPIRPGTD
A
AL
VA
GIAWVLI
N
EN
L
VDQPFLDKYCVGYDEKTLPA
D
AP
K
N
G
HYKAYILGEG
D
D
N
TAKTP
Q
WA
S
Q
ITGIP
VD
R
IIKLAREIG
T
AKPAYICQGWGPQRQ
A
NGE
L
T
A
RAIAML
PI
LTGNVGI
S
GGNSG
-----------
A
RE
S
TYTITI
E
R
LP
V
L
D
NPVKT
S
IS
C
F
S
WTDAIDHG
PQ
MTAIR
-----
DGVR
---------
GK
D
KLDVPIKFIW
N
YAGNTL
V
NQH
S
DIN
K
THE
I
LQD
E
SKCEMIVVIE
N
FMT
S
SAKYADILLPDLM
TV
EQED
I
I
PNDY
AGNMGY
L
I
FL
QP
V
TS
E
KFERKPIYW
I
LSEVAKRLGPDVYQ
K
FTEGR
T
Q
EQ
WL
Q
H
LY
----
AK
ML
A
K
D
P
A
L
P
S
Y
D
E
L
K
KM
GI
Y
---
KRK
D
PN
G
H
F
VAY
K
AFR
D
DP
E
ANPLKTPSGKIEIYS
SR
LA
E
IA
-------
R
TWEL
E
KDE
V
I
S
PLP
V
Y
AST
F
E
GWD
S
P
E
R
S
T
F
PLQL
F
GFHYK
S
RTHS
T
YGNID
V
LK
A
---
ACRQEVWINPIDAQ
K
RGIANGD
M
VRVFN
H
RGE
V
R
LP
AKVTPRILPGV
S
A
M
GQGAW
H
E
A
N
M
S
GD
K
I
DHGG
C
V
N
T
LT
T
L
RPSP
-
LAKGNP
Q
H
T
NLV
E
IEK
fig|344601.5.peg.329
Escherichia coli B171 (10-807/808)
ISRR
T
L
V
K
S
T
AIGSLALA
AGG
F
S
LPF
T
--
L
R
S
AAA
A
V
-
QQ
A
R
EK
V
VWG
A
C
S
VNCGSRCALRLHVKD
NE
V
T
WVE
T
D
N
TG
S
D
E
Y
-
GNHQVRACLRGRSIRR
-----
RINHP
----
DRL
N
YPMKRVGKRGEGKFERISWDEALDTI
ASS
L
K
KT
V
E
Q
YGNEAV
Y
IQ
Y
S
S
G
IV
GGN
M
T
R
S
SPS
A
SA
-
VK
RLMN
CY
GG
S
L
NQ
YGSYSTAQIS
C
AMPY
TY
GS
-----
NDGNS
T
T
DIENSKLVVMFGNNPAET
------
RMSGGG
I
TY
LL
E
K
AREKSNA
K
MIVIDPRY
T
DTAA
--
GREDEWLPIRPGTD
A
AL
VA
GIAWVLI
N
EN
L
VDQPFLDKYCVGYDEKTLPA
D
AP
K
N
G
HYKAYILGEG
D
D
N
TAKTP
Q
WA
S
Q
ITGIP
VD
R
IIKLAREIG
T
AKPAYICQGWGPQRQ
A
NGE
L
T
A
RAIAML
PI
LTGNVGI
S
GGNSG
-----------
A
RE
S
TYTITI
E
R
LP
V
L
D
NPVKT
S
IS
C
F
S
WTDAIDHG
PQ
MTAIR
-----
DGVR
---------
GK
D
KLDVPIKFIW
N
YAGNTL
V
NQH
S
DIN
K
THE
I
LQD
E
SKCEMIVVIE
N
FMT
S
SAKYADILLPDLM
TV
EQED
I
I
PNDY
AGNMGY
L
I
FL
QP
V
TS
E
KFERKPIYW
I
LSEVAKRLGPDVYQ
K
FTEGR
T
Q
EQ
WL
Q
H
LY
----
AK
ML
A
K
D
P
A
L
P
S
Y
D
E
L
K
KM
GI
Y
---
KRK
D
PN
G
H
F
VAY
K
AFR
D
DP
E
ANPLKTPSGKIEIYS
SR
LA
E
IA
-------
R
TWEL
E
KDE
V
I
S
PLP
V
Y
AST
F
E
GWD
S
P
E
R
S
T
F
PLQL
F
GFHYK
S
RTHS
T
YGNID
V
LK
A
---
ACRQEVWINPIDAQ
K
RGIANGD
M
VRVFN
H
RGE
V
R
LP
AKVTPRILPGV
S
A
M
GQGAW
H
E
A
N
M
S
GD
K
I
DHGG
C
V
N
T
LT
T
L
RPSP
-
LAKGNP
Q
H
T
NLV
E
IEK
fig|550676.3.peg.1891
Escherichia coli B185 (10-807/808)
ISRR
T
L
V
K
S
T
AIGSLALA
AGG
F
S
LPF
T
--
L
H
S
AAA
A
V
-
QQ
A
R
EK
V
VWG
A
C
S
VNCGSRCALRLHVKD
NE
V
A
WVE
T
D
N
TG
S
D
E
Y
-
GNHQVRACLRGRSIRR
-----
RINHP
----
DRL
N
YPMKRVGKRGEGKFERISWDEALDTI
ASS
L
K
KT
V
E
Q
YGNEAV
Y
IQ
Y
S
S
G
IV
GGN
M
T
R
S
SPS
A
SA
-
VK
RLMN
CY
GG
S
L
NQ
YGSYSTAQIS
C
AMPY
TY
GS
-----
NDGNS
T
T
DIENSKLVVMFGNNPAET
------
RMSGGG
I
TY
LL
E
K
AREKSNA
K
MIVIDPRY
T
DTAA
--
GREDEWLPIRPGTD
A
AL
VA
GIAWVLI
N
EN
L
VDQPFLDKYCVGYDEKTLPA
D
AP
K
N
G
HYKAYILGEG
D
D
K
TAKTP
Q
WA
S
Q
ITGIP
VD
R
IIKLAREIG
T
AKPAYICQGWGPQRQ
A
NGE
L
T
A
RAIAML
PI
LTGNVGI
S
GGNSG
-----------
A
RE
S
TYTITI
E
R
LP
V
L
D
NPVKT
S
IS
C
F
S
WTDAIDHG
PQ
MTAIR
-----
DGVR
---------
GK
D
KL
E
VPIKFIW
N
YAGNTL
V
NQH
S
DIN
K
THE
I
LQD
E
SKCEMIVVIE
N
FMT
S
SAKYADILLPDLM
TV
EQED
I
I
PNDY
AGNMGY
L
I
FL
QP
V
TS
E
KFERKPIYW
I
LSEVAKRLGPDVYQ
K
FTEGR
T
Q
EQ
WL
Q
H
LY
----
AK
ML
A
K
D
P
A
L
P
S
Y
D
E
L
K
KM
GI
Y
---
KRK
D
PN
G
H
F
VAY
K
AFR
D
DP
E
ANPLKTPSGKIEIYS
SK
LA
E
IA
-------
R
TWEL
E
KDE
V
I
S
PLP
V
Y
AST
F
E
GWD
S
P
E
R
S
T
F
PLQL
F
GFHYK
S
RTHS
T
YGNID
V
LK
A
---
ACRQEVWINPIDAQ
K
RGIANGD
M
VRVFN
H
RGE
V
R
LP
AKVTPRILPGV
S
A
M
GQGAW
H
E
A
N
M
S
GD
K
I
DHGG
C
V
N
T
LT
T
L
RPSP
-
LAKGNP
Q
H
T
NLV
E
IEK
fig|685038.3.peg.1602
Escherichia coli O83:H1 str. NRG 857C (10-807/808)
ISRR
T
L
V
K
S
T
AIGSLALA
AGG
F
S
LPF
T
--
L
R
S
A
E
A
A
V
-
QQ
A
N
EK
V
VWG
A
C
S
VNCGSRCALRLHVKD
NE
V
T
WVE
T
D
N
TG
S
D
E
Y
-
GNHQVRACLRGRSIRR
-----
RINHP
----
DRL
N
YPMKRVGKRGEGKFERISWDEALDTI
ASS
L
K
KT
V
K
Q
YGNEAV
Y
IQ
Y
S
S
G
IV
GGN
M
T
R
S
SPS
A
SA
-
VK
RLMN
CY
GG
S
L
NQ
YGSYSTAQIS
C
AMPY
TY
GS
-----
NDGNS
T
T
DIENSKLVVMFGNNPAET
------
RMSGGG
I
TY
LL
E
K
AREKSNA
K
MIVIDPRY
T
DTAA
--
GREDEWLPIRPGTD
A
AL
VA
GIAWVLI
N
EN
L
VDQPFLDKYCVGYDEK
N
LPA
D
AP
K
N
G
HYKAYILGEG
D
D
K
TAKTP
Q
WA
S
Q
ITGIP
VD
R
IIKLAREIG
T
AKPAYICQGWGPQRQ
A
NGE
L
T
A
RAIAML
PI
LTGNVGI
S
GGNSG
-----------
A
RE
S
TYTITI
E
R
LP
V
L
D
NPVKT
S
IS
C
F
S
WTDAIDHG
PQ
MTAIR
-----
DGVR
---------
GK
D
KLDVPIKFIW
N
YAGNTL
V
NQH
S
DIN
K
THE
I
LQD
E
SKCEMIVVIE
N
FMT
S
SAKYADILLPDLM
TV
EQED
I
I
PNDY
AGNMGY
L
I
FL
QP
V
TS
E
KFERKPIYW
I
LSEVAKRLGPDVYQ
K
FTEGR
T
Q
EQ
WL
Q
H
LY
----
AK
ML
A
K
D
P
A
L
P
S
Y
D
E
L
K
KM
GI
Y
---
KRK
D
PN
G
H
F
VAY
K
AFR
D
DP
E
ANPLKTPSGKIEIYS
SK
LA
E
IA
-------
R
TWEL
E
KDE
V
I
S
PLP
V
Y
AST
F
E
GWD
S
P
E
R
SA
F
PLQL
F
GFHYK
S
RTHS
T
YGN
V
D
V
LK
A
---
ACRQEVWINPIDAQ
K
RGIANGD
M
VRVFN
H
RGE
V
R
LP
AKVTPRILPGV
S
A
M
GQGAW
H
E
A
N
M
S
GD
K
I
DHGG
C
V
N
T
LT
T
L
RPSP
-
LAKGNP
Q
H
T
NLV
E
IEK
fig|525281.3.peg.976
Escherichia coli 83972 (10-807/808)
ISRR
T
L
V
K
S
T
AIGSLALA
AGG
F
S
LPF
T
--
L
R
S
A
E
A
A
V
-
QQ
A
N
EK
V
VWG
A
C
S
VNCGSRCALRLHVKD
NE
V
T
WVE
T
D
N
TG
S
D
E
Y
-
GNHQVRACLRGRSIRR
-----
RINHP
----
DRL
N
YPMKRVGKRGEGKFERISWDEALDTI
ASS
L
K
KT
V
K
Q
YGNEAV
Y
IQ
Y
S
S
G
IV
GGN
M
T
R
S
SPS
A
SA
-
VK
RLMN
CY
GG
S
L
NQ
YGSYSTAQIS
C
AMPY
TY
GS
-----
NDGNS
T
T
DIENSKLVVMFGNNPAET
------
RMSGGG
I
TY
LL
E
K
AREKSNA
K
MIVIDPRY
T
DTAA
--
GREDEWLPIRPGTD
A
AL
VA
GIAWVLI
N
EN
L
VDQPFLDKYCVGYDEKTLPA
D
AP
K
N
G
HYKAYILGEG
D
D
K
TAKTP
Q
WA
S
Q
ITGIP
VD
R
IIKLAREIG
T
AKPAYICQGWGPQRQ
A
NGE
L
T
A
RAIAML
PI
LTGNVGI
S
GGNSG
-----------
A
RE
S
TYTITI
E
R
LP
V
L
D
NPVKT
S
IS
C
F
S
WTDAIDHG
PQ
MTAIR
-----
DGVR
---------
GK
D
KLDVPIKFIW
N
YAGNTL
V
NQH
S
DIN
K
THE
I
LQD
E
SKCEMIVVIE
N
FMT
S
SAKYADILLPDLM
TV
EQED
I
I
PNDY
AGNMGY
L
I
FL
QP
V
TS
E
KFERKPIYW
I
LSEVAKRLGPDVYQ
K
FTEGR
T
Q
EQ
WL
Q
H
LY
----
AK
ML
A
K
D
P
A
L
P
S
Y
D
E
L
K
KM
GI
Y
---
KRK
D
PN
G
H
F
VAY
K
AFR
D
DP
E
ANPLKTPSGKIEIYS
SK
LA
E
IA
-------
R
TWEL
E
KDE
V
I
S
PLP
V
Y
AST
F
E
GWD
S
P
E
R
SA
F
PLQL
F
GFHYK
S
RTHS
T
YGNID
V
LK
A
---
ACRQEVWINPIDAQ
K
RGIANGD
M
VRVFN
H
RGE
V
R
LP
AKVTPRILPGV
S
A
M
GQGAW
H
E
A
N
M
S
GD
K
I
DHGG
C
V
N
T
LT
T
L
RPSP
-
LAKGNP
Q
H
T
NLV
E
IEK
fig|655817.3.peg.1868
Escherichia coli ABU 83972 (10-807/808)
ISRR
T
L
V
K
S
T
AIGSLALA
AGG
F
S
LPF
T
--
L
R
S
A
E
A
A
V
-
QQ
A
N
EK
V
VWG
A
C
S
VNCGSRCALRLHVKD
NE
V
T
WVE
T
D
N
TG
S
D
E
Y
-
GNHQVRACLRGRSIRR
-----
RINHP
----
DRL
N
YPMKRVGKRGEGKFERISWDEALDTI
ASS
L
K
KT
V
K
Q
YGNEAV
Y
IQ
Y
S
S
G
IV
GGN
M
T
R
S
SPS
A
SA
-
VK
RLMN
CY
GG
S
L
NQ
YGSYSTAQIS
C
AMPY
TY
GS
-----
NDGNS
T
T
DIENSKLVVMFGNNPAET
------
RMSGGG
I
TY
LL
E
K
AREKSNA
K
MIVIDPRY
T
DTAA
--
GREDEWLPIRPGTD
A
AL
VA
GIAWVLI
N
EN
L
VDQPFLDKYCVGYDEKTLPA
D
AP
K
N
G
HYKAYILGEG
D
D
K
TAKTP
Q
WA
S
Q
ITGIP
VD
R
IIKLAREIG
T
AKPAYICQGWGPQRQ
A
NGE
L
T
A
RAIAML
PI
LTGNVGI
S
GGNSG
-----------
A
RE
S
TYTITI
E
R
LP
V
L
D
NPVKT
S
IS
C
F
S
WTDAIDHG
PQ
MTAIR
-----
DGVR
---------
GK
D
KLDVPIKFIW
N
YAGNTL
V
NQH
S
DIN
K
THE
I
LQD
E
SKCEMIVVIE
N
FMT
S
SAKYADILLPDLM
TV
EQED
I
I
PNDY
AGNMGY
L
I
FL
QP
V
TS
E
KFERKPIYW
I
LSEVAKRLGPDVYQ
K
FTEGR
T
Q
EQ
WL
Q
H
LY
----
AK
ML
A
K
D
P
A
L
P
S
Y
D
E
L
K
KM
GI
Y
---
KRK
D
PN
G
H
F
VAY
K
AFR
D
DP
E
ANPLKTPSGKIEIYS
SK
LA
E
IA
-------
R
TWEL
E
KDE
V
I
S
PLP
V
Y
AST
F
E
GWD
S
P
E
R
SA
F
PLQL
F
GFHYK
S
RTHS
T
YGNID
V
LK
A
---
ACRQEVWINPIDAQ
K
RGIANGD
M
VRVFN
H
RGE
V
R
LP
AKVTPRILPGV
S
A
M
GQGAW
H
E
A
N
M
S
GD
K
I
DHGG
C
V
N
T
LT
T
L
RPSP
-
LAKGNP
Q
H
T
NLV
E
IEK
fig|405955.13.peg.1670
Escherichia coli APEC O1 (10-807/808)
ISRR
T
L
V
K
S
T
AIGSLALA
AGG
F
S
LPF
T
--
L
R
S
A
E
A
A
V
-
QQ
A
N
EK
V
VWG
A
C
S
VNCGSRCALRLHVKD
NE
V
T
WVE
T
D
N
TG
S
D
E
Y
-
GNHQVRACLRGRSIRR
-----
RINHP
----
DRL
N
YPMKRVGKRGEGKFERISWDEALDTI
ASS
L
K
KT
V
K
Q
YGNEAV
Y
IQ
Y
S
S
G
IV
GGN
M
T
R
S
SPS
A
SA
-
VK
RLMN
CY
GG
S
L
NQ
YGSYSTAQIS
C
AMPY
TY
GS
-----
NDGNS
T
T
DIENSKLVVMFGNNPAET
------
RMSGGG
I
TY
LL
E
K
AREKSNA
K
MIVIDPRY
T
DTAA
--
GREDEWLPIRPGTD
A
AL
VA
GIAWVLI
N
EN
L
VDQPFLDKYCVGYDEKTLPA
D
AP
K
N
G
HYKAYILGEG
D
D
K
TAKTP
Q
WA
S
Q
ITGIP
VD
R
IIKLAREIG
T
AKPAYICQGWGPQRQ
A
NGE
L
T
A
RAIAML
PI
LTGNVGI
S
GGNSG
-----------
A
RE
S
TYTITI
E
R
LP
V
L
D
NPVKT
S
IS
C
F
S
WTDAIDHG
PQ
MTAIR
-----
DGVR
---------
GK
D
KLDVPIKFIW
N
YAGNTL
V
NQH
S
DIN
K
THE
I
LQD
E
SKCEMIVVIE
N
FMT
S
SAKYADILLPDLM
TV
EQED
I
I
PNDY
AGNMGY
L
I
FL
QP
V
TS
E
KFERKPIYW
I
LSEVAKRLGPDVYQ
K
FTEGR
T
Q
EQ
WL
Q
H
LY
----
AK
ML
A
K
D
P
A
L
P
S
Y
D
E
L
K
KM
GI
Y
---
KRK
D
PN
G
H
F
VAY
K
AFR
D
DP
E
ANPLKTPSGKIEIYS
SK
LA
E
IA
-------
R
TWEL
E
KDE
V
I
S
PLP
V
Y
AST
F
E
GWD
S
P
E
R
SA
F
PLQL
F
GFHYK
S
RTHS
T
YGNID
V
LK
A
---
ACRQEVWINPIDAQ
K
RGIANGD
M
VRVFN
H
RGE
V
R
LP
AKVTPRILPGV
S
A
M
GQGAW
H
E
A
N
M
S
GD
K
I
DHGG
C
V
N
T
LT
T
L
RPSP
-
LAKGNP
Q
H
T
NLV
E
IEK
fig|405955.9.peg.1355
Escherichia coli APEC O1 (10-807/808)
ISRR
T
L
V
K
S
T
AIGSLALA
AGG
F
S
LPF
T
--
L
R
S
A
E
A
A
V
-
QQ
A
N
EK
V
VWG
A
C
S
VNCGSRCALRLHVKD
NE
V
T
WVE
T
D
N
TG
S
D
E
Y
-
GNHQVRACLRGRSIRR
-----
RINHP
----
DRL
N
YPMKRVGKRGEGKFERISWDEALDTI
ASS
L
K
KT
V
K
Q
YGNEAV
Y
IQ
Y
S
S
G
IV
GGN
M
T
R
S
SPS
A
SA
-
VK
RLMN
CY
GG
S
L
NQ
YGSYSTAQIS
C
AMPY
TY
GS
-----
NDGNS
T
T
DIENSKLVVMFGNNPAET
------
RMSGGG
I
TY
LL
E
K
AREKSNA
K
MIVIDPRY
T
DTAA
--
GREDEWLPIRPGTD
A
AL
VA
GIAWVLI
N
EN
L
VDQPFLDKYCVGYDEKTLPA
D
AP
K
N
G
HYKAYILGEG
D
D
K
TAKTP
Q
WA
S
Q
ITGIP
VD
R
IIKLAREIG
T
AKPAYICQGWGPQRQ
A
NGE
L
T
A
RAIAML
PI
LTGNVGI
S
GGNSG
-----------
A
RE
S
TYTITI
E
R
LP
V
L
D
NPVKT
S
IS
C
F
S
WTDAIDHG
PQ
MTAIR
-----
DGVR
---------
GK
D
KLDVPIKFIW
N
YAGNTL
V
NQH
S
DIN
K
THE
I
LQD
E
SKCEMIVVIE
N
FMT
S
SAKYADILLPDLM
TV
EQED
I
I
PNDY
AGNMGY
L
I
FL
QP
V
TS
E
KFERKPIYW
I
LSEVAKRLGPDVYQ
K
FTEGR
T
Q
EQ
WL
Q
H
LY
----
AK
ML
A
K
D
P
A
L
P
S
Y
D
E
L
K
KM
GI
Y
---
KRK
D
PN
G
H
F
VAY
K
AFR
D
DP
E
ANPLKTPSGKIEIYS
SK
LA
E
IA
-------
R
TWEL
E
KDE
V
I
S
PLP
V
Y
AST
F
E
GWD
S
P
E
R
SA
F
PLQL
F
GFHYK
S
RTHS
T
YGNID
V
LK
A
---
ACRQEVWINPIDAQ
K
RGIANGD
M
VRVFN
H
RGE
V
R
LP
AKVTPRILPGV
S
A
M
GQGAW
H
E
A
N
M
S
GD
K
I
DHGG
C
V
N
T
LT
T
L
RPSP
-
LAKGNP
Q
H
T
NLV
E
IEK
fig|199310.1.peg.1915
Escherichia coli CFT073 (10-807/808)
ISRR
T
L
V
K
S
T
AIGSLALA
AGG
F
S
LPF
T
--
L
R
S
A
E
A
A
V
-
QQ
A
N
EK
V
VWG
A
C
S
VNCGSRCALRLHVKD
NE
V
T
WVE
T
D
N
TG
S
D
E
Y
-
GNHQVRACLRGRSIRR
-----
RINHP
----
DRL
N
YPMKRVGKRGEGKFERISWDEALDTI
ASS
L
K
KT
V
K
Q
YGNEAV
Y
IQ
Y
S
S
G
IV
GGN
M
T
R
S
SPS
A
SA
-
VK
RLMN
CY
GG
S
L
NQ
YGSYSTAQIS
C
AMPY
TY
GS
-----
NDGNS
T
T
DIENSKLVVMFGNNPAET
------
RMSGGG
I
TY
LL
E
K
AREKSNA
K
MIVIDPRY
T
DTAA
--
GREDEWLPIRPGTD
A
AL
VA
GIAWVLI
N
EN
L
VDQPFLDKYCVGYDEKTLPA
D
AP
K
N
G
HYKAYILGEG
D
D
K
TAKTP
Q
WA
S
Q
ITGIP
VD
R
IIKLAREIG
T
AKPAYICQGWGPQRQ
A
NGE
L
T
A
RAIAML
PI
LTGNVGI
S
GGNSG
-----------
A
RE
S
TYTITI
E
R
LP
V
L
D
NPVKT
S
IS
C
F
S
WTDAIDHG
PQ
MTAIR
-----
DGVR
---------
GK
D
KLDVPIKFIW
N
YAGNTL
V
NQH
S
DIN
K
THE
I
LQD
E
SKCEMIVVIE
N
FMT
S
SAKYADILLPDLM
TV
EQED
I
I
PNDY
AGNMGY
L
I
FL
QP
V
TS
E
KFERKPIYW
I
LSEVAKRLGPDVYQ
K
FTEGR
T
Q
EQ
WL
Q
H
LY
----
AK
ML
A
K
D
P
A
L
P
S
Y
D
E
L
K
KM
GI
Y
---
KRK
D
PN
G
H
F
VAY
K
AFR
D
DP
E
ANPLKTPSGKIEIYS
SK
LA
E
IA
-------
R
TWEL
E
KDE
V
I
S
PLP
V
Y
AST
F
E
GWD
S
P
E
R
SA
F
PLQL
F
GFHYK
S
RTHS
T
YGNID
V
LK
A
---
ACRQEVWINPIDAQ
K
RGIANGD
M
VRVFN
H
RGE
V
R
LP
AKVTPRILPGV
S
A
M
GQGAW
H
E
A
N
M
S
GD
K
I
DHGG
C
V
N
T
LT
T
L
RPSP
-
LAKGNP
Q
H
T
NLV
E
IEK
fig|199310.4.peg.1846
Escherichia coli CFT073 (10-807/808)
ISRR
T
L
V
K
S
T
AIGSLALA
AGG
F
S
LPF
T
--
L
R
S
A
E
A
A
V
-
QQ
A
N
EK
V
VWG
A
C
S
VNCGSRCALRLHVKD
NE
V
T
WVE
T
D
N
TG
S
D
E
Y
-
GNHQVRACLRGRSIRR
-----
RINHP
----
DRL
N
YPMKRVGKRGEGKFERISWDEALDTI
ASS
L
K
KT
V
K
Q
YGNEAV
Y
IQ
Y
S
S
G
IV
GGN
M
T
R
S
SPS
A
SA
-
VK
RLMN
CY
GG
S
L
NQ
YGSYSTAQIS
C
AMPY
TY
GS
-----
NDGNS
T
T
DIENSKLVVMFGNNPAET
------
RMSGGG
I
TY
LL
E
K
AREKSNA
K
MIVIDPRY
T
DTAA
--
GREDEWLPIRPGTD
A
AL
VA
GIAWVLI
N
EN
L
VDQPFLDKYCVGYDEKTLPA
D
AP
K
N
G
HYKAYILGEG
D
D
K
TAKTP
Q
WA
S
Q
ITGIP
VD
R
IIKLAREIG
T
AKPAYICQGWGPQRQ
A
NGE
L
T
A
RAIAML
PI
LTGNVGI
S
GGNSG
-----------
A
RE
S
TYTITI
E
R
LP
V
L
D
NPVKT
S
IS
C
F
S
WTDAIDHG
PQ
MTAIR
-----
DGVR
---------
GK
D
KLDVPIKFIW
N
YAGNTL
V
NQH
S
DIN
K
THE
I
LQD
E
SKCEMIVVIE
N
FMT
S
SAKYADILLPDLM
TV
EQED
I
I
PNDY
AGNMGY
L
I
FL
QP
V
TS
E
KFERKPIYW
I
LSEVAKRLGPDVYQ
K
FTEGR
T
Q
EQ
WL
Q
H
LY
----
AK
ML
A
K
D
P
A
L
P
S
Y
D
E
L
K
KM
GI
Y
---
KRK
D
PN
G
H
F
VAY
K
AFR
D
DP
E
ANPLKTPSGKIEIYS
SK
LA
E
IA
-------
R
TWEL
E
KDE
V
I
S
PLP
V
Y
AST
F
E
GWD
S
P
E
R
SA
F
PLQL
F
GFHYK
S
RTHS
T
YGNID
V
LK
A
---
ACRQEVWINPIDAQ
K
RGIANGD
M
VRVFN
H
RGE
V
R
LP
AKVTPRILPGV
S
A
M
GQGAW
H
E
A
N
M
S
GD
K
I
DHGG
C
V
N
T
LT
T
L
RPSP
-
LAKGNP
Q
H
T
NLV
E
IEK
fig|749546.3.peg.3879
Escherichia coli MS 185-1 (10-807/808)
ISRR
T
L
V
K
S
T
AIGSLALA
AGG
F
S
LPF
T
--
L
R
S
A
E
A
A
V
-
QQ
A
N
EK
V
VWG
A
C
S
VNCGSRCALRLHVKD
NE
V
T
WVE
T
D
N
TG
S
D
E
Y
-
GNHQVRACLRGRSIRR
-----
RINHP
----
DRL
N
YPMKRVGKRGEGKFERISWDEALDTI
ASS
L
K
KT
V
K
Q
YGNEAV
Y
IQ
Y
S
S
G
IV
GGN
M
T
R
S
SPS
A
SA
-
VK
RLMN
CY
GG
S
L
NQ
YGSYSTAQIS
C
AMPY
TY
GS
-----
NDGNS
T
T
DIENSKLVVMFGNNPAET
------
RMSGGG
I
TY
LL
E
K
AREKSNA
K
MIVIDPRY
T
DTAA
--
GREDEWLPIRPGTD
A
AL
VA
GIAWVLI
N
EN
L
VDQPFLDKYCVGYDEKTLPA
D
AP
K
N
G
HYKAYILGEG
D
D
K
TAKTP
Q
WA
S
Q
ITGIP
VD
R
IIKLAREIG
T
AKPAYICQGWGPQRQ
A
NGE
L
T
A
RAIAML
PI
LTGNVGI
S
GGNSG
-----------
A
RE
S
TYTITI
E
R
LP
V
L
D
NPVKT
S
IS
C
F
S
WTDAIDHG
PQ
MTAIR
-----
DGVR
---------
GK
D
KLDVPIKFIW
N
YAGNTL
V
NQH
S
DIN
K
THE
I
LQD
E
SKCEMIVVIE
N
FMT
S
SAKYADILLPDLM
TV
EQED
I
I
PNDY
AGNMGY
L
I
FL
QP
V
TS
E
KFERKPIYW
I
LSEVAKRLGPDVYQ
K
FTEGR
T
Q
EQ
WL
Q
H
LY
----
AK
ML
A
K
D
P
A
L
P
S
Y
D
E
L
K
KM
GI
Y
---
KRK
D
PN
G
H
F
VAY
K
AFR
D
DP
E
ANPLKTPSGKIEIYS
SK
LA
E
IA
-------
R
TWEL
E
KDE
V
I
S
PLP
V
Y
AST
F
E
GWD
S
P
E
R
SA
F
PLQL
F
GFHYK
S
RTHS
T
YGNID
V
LK
A
---
ACRQEVWINPIDAQ
K
RGIANGD
M
VRVFN
H
RGE
V
R
LP
AKVTPRILPGV
S
A
M
GQGAW
H
E
A
N
M
S
GD
K
I
DHGG
C
V
N
T
LT
T
L
RPSP
-
LAKGNP
Q
H
T
NLV
E
IEK
fig|749528.3.peg.3857
Escherichia coli MS 45-1 (10-807/808)
ISRR
T
L
V
K
S
T
AIGSLALA
AGG
F
S
LPF
T
--
L
R
S
A
E
A
A
V
-
QQ
A
N
EK
V
VWG
A
C
S
VNCGSRCALRLHVKD
NE
V
T
WVE
T
D
N
TG
S
D
E
Y
-
GNHQVRACLRGRSIRR
-----
RINHP
----
DRL
N
YPMKRVGKRGEGKFERISWDEALDTI
ASS
L
K
KT
V
K
Q
YGNEAV
Y
IQ
Y
S
S
G
IV
GGN
M
T
R
S
SPS
A
SA
-
VK
RLMN
CY
GG
S
L
NQ
YGSYSTAQIS
C
AMPY
TY
GS
-----
NDGNS
T
T
DIENSKLVVMFGNNPAET
------
RMSGGG
I
TY
LL
E
K
AREKSNA
K
MIVIDPRY
T
DTAA
--
GREDEWLPIRPGTD
A
AL
VA
GIAWVLI
N
EN
L
VDQPFLDKYCVGYDEKTLPA
D
AP
K
N
G
HYKAYILGEG
D
D
K
TAKTP
Q
WA
S
Q
ITGIP
VD
R
IIKLAREIG
T
AKPAYICQGWGPQRQ
A
NGE
L
T
A
RAIAML
PI
LTGNVGI
S
GGNSG
-----------
A
RE
S
TYTITI
E
R
LP
V
L
D
NPVKT
S
IS
C
F
S
WTDAIDHG
PQ
MTAIR
-----
DGVR
---------
GK
D
KLDVPIKFIW
N
YAGNTL
V
NQH
S
DIN
K
THE
I
LQD
E
SKCEMIVVIE
N
FMT
S
SAKYADILLPDLM
TV
EQED
I
I
PNDY
AGNMGY
L
I
FL
QP
V
TS
E
KFERKPIYW
I
LSEVAKRLGPDVYQ
K
FTEGR
T
Q
EQ
WL
Q
H
LY
----
AK
ML
A
K
D
P
A
L
P
S
Y
D
E
L
K
KM
GI
Y
---
KRK
D
PN
G
H
F
VAY
K
AFR
D
DP
E
ANPLKTPSGKIEIYS
SK
LA
E
IA
-------
R
TWEL
E
KDE
V
I
S
PLP
V
Y
AST
F
E
GWD
S
P
E
R
SA
F
PLQL
F
GFHYK
S
RTHS
T
YGNID
V
LK
A
---
ACRQEVWINPIDAQ
K
RGIANGD
M
VRVFN
H
RGE
V
R
LP
AKVTPRILPGV
S
A
M
GQGAW
H
E
A
N
M
S
GD
K
I
DHGG
C
V
N
T
LT
T
L
RPSP
-
LAKGNP
Q
H
T
NLV
E
IEK
fig|753642.3.peg.1576
Escherichia coli NC101 (10-807/808)
ISRR
T
L
V
K
S
T
AIGSLALA
ADG
F
S
LPF
T
--
L
R
S
A
E
A
A
V
-
QQ
A
N
EK
V
VWG
A
C
S
VNCGSRCALRLHVKD
NE
V
T
WVE
T
D
N
TG
S
D
E
Y
-
GNHQVRACLRGRSIRR
-----
RINHP
----
DRL
N
YPMKRVGKRGEGKFERISWDEALDTI
ASS
L
K
KT
V
K
Q
YGNEAV
Y
IQ
Y
S
S
G
IV
GGN
M
T
R
S
SPS
A
SA
-
VK
RLMN
CY
GG
S
L
NQ
YGSYSTAQIS
C
AMPY
TY
GS
-----
NDGNS
T
T
DIENSKLVVMFGNNPAET
------
RMSGGG
I
TY
LL
E
K
AREKSNA
K
MIVIDPRY
T
DTAA
--
GREDEWLPIRPGTD
A
AL
VA
GIAWVLI
N
EN
L
VDQPFLDKYCVGYDEKTLPA
D
AP
K
N
G
HYKAYILGEG
D
D
K
TAKTP
Q
WA
S
Q
ITGIP
VD
R
IIKLAREIG
T
AKPAYICQGWGPQRQ
A
NGE
L
T
A
RAIAML
PI
LTGNVGI
S
GGNSG
-----------
A
RE
S
TYTITI
E
R
LP
V
L
D
NPVKT
S
IS
C
F
S
WTDAIDHG
PQ
MTAIR
-----
DGVR
---------
GK
D
KLDVPIKFIW
N
YAGNTL
V
NQH
S
DIN
K
THE
I
LQD
E
SKCEMIVVIE
N
FMT
S
SAKYADILLPDLM
TV
EQED
I
I
PNDY
AGNMGY
L
I
FL
QP
V
TS
E
KFERKPIYW
I
LSEVAKRLGPDVYQ
K
FTEGR
T
Q
EQ
WL
Q
H
LY
----
AK
ML
A
K
D
P
A
L
P
S
Y
D
E
L
K
KM
GI
Y
---
KRK
D
PN
G
H
F
VAY
K
AFR
D
DP
E
ANPLKTPSGKIEIYS
SK
LA
E
IA
-------
R
TWEL
E
KDE
V
I
S
PLP
V
Y
AST
F
E
GWD
S
P
E
R
SA
F
PLQL
F
GFHYK
S
RTHS
T
YGNID
V
LK
A
---
ACRQEVWINPIDAQ
K
RGIANGD
M
VRVFN
H
RGE
V
R
LP
AKVTPRILPGV
S
A
M
GQGAW
H
E
A
N
M
S
GD
K
I
DHGG
C
V
N
T
LT
T
L
RPSP
-
LAKGNP
Q
H
T
NLV
E
IEK
fig|585035.6.peg.1625
Escherichia coli S88 (10-807/808)
ISRR
T
L
V
K
S
T
AIGSLALA
AGG
F
S
LPF
T
--
L
R
S
A
E
A
A
V
-
QQ
A
N
EK
V
VWG
A
C
S
VNCGSRCALRLHVKD
NE
V
T
WVE
T
D
N
TG
S
D
E
Y
-
GNHQVRACLRGRSIRR
-----
RINHP
----
DRL
N
YPMKRVGKRGEGKFERISWDEALDTI
ASS
L
K
KT
V
K
Q
YGNEAV
Y
IQ
Y
S
S
G
IV
GGN
M
T
R
S
SPS
A
SA
-
VK
RLMN
CY
GG
S
L
NQ
YGSYSTAQIS
C
AMPY
TY
GS
-----
NDGNS
T
T
DIENSKLVVMFGNNPAET
------
RMSGGG
I
TY
LL
E
K
AREKSNA
K
MIVIDPRY
T
DTAA
--
GREDEWLPIRPGTD
A
AL
VA
GIAWVLI
N
EN
L
VDQPFLDKYCVGYDEKTLPA
D
AP
K
N
G
HYKAYILGEG
D
D
K
TAKTP
Q
WA
S
Q
ITGIP
VD
R
IIKLAREIG
T
AKPAYICQGWGPQRQ
A
NGE
L
T
A
RAIAML
PI
LTGNVGI
S
GGNSG
-----------
A
RE
S
TYTITI
E
R
LP
V
L
D
NPVKT
S
IS
C
F
S
WTDAIDHG
PQ
MTAIR
-----
DGVR
---------
GK
D
KLDVPIKFIW
N
YAGNTL
V
NQH
S
DIN
K
THE
I
LQD
E
SKCEMIVVIE
N
FMT
S
SAKYADILLPDLM
TV
EQED
I
I
PNDY
AGNMGY
L
I
FL
QP
V
TS
E
KFERKPIYW
I
LSEVAKRLGPDVYQ
K
FTEGR
T
Q
EQ
WL
Q
H
LY
----
AK
ML
A
K
D
P
A
L
P
S
Y
D
E
L
K
KM
GI
Y
---
KRK
D
PN
G
H
F
VAY
K
AFR
D
DP
E
ANPLKTPSGKIEIYS
SK
LA
E
IA
-------
R
TWEL
E
KDE
V
I
S
PLP
V
Y
AST
F
E
GWD
S
P
E
R
SA
F
PLQL
F
GFHYK
S
RTHS
T
YGNID
V
LK
A
---
ACRQEVWINPIDAQ
K
RGIANGD
M
VRVFN
H
RGE
V
R
LP
AKVTPRILPGV
S
A
M
GQGAW
H
E
A
N
M
S
GD
K
I
DHGG
C
V
N
T
LT
T
L
RPSP
-
LAKGNP
Q
H
T
NLV
E
IEK
fig|364106.7.peg.1817
Escherichia coli UTI89 (10-807/808)
ISRR
T
L
V
K
S
T
AIGSLALA
AGG
F
S
LPF
T
--
L
R
S
A
E
A
A
V
-
QQ
A
N
EK
V
VWG
A
C
S
VNCGSRCALRLHVKD
NE
V
T
WVE
T
D
N
TG
S
D
E
Y
-
GNHQVRACLRGRSIRR
-----
RINHP
----
DRL
N
YPMKRVGKRGEGKFERISWDEALDTI
ASS
L
K
KT
V
K
Q
YGNEAV
Y
IQ
Y
S
S
G
IV
GGN
M
T
R
S
SPS
A
SA
-
VK
RLMN
CY
GG
S
L
NQ
YGSYSTAQIS
C
AMPY
TY
GS
-----
NDGNS
T
T
DIENSKLVVMFGNNPAET
------
RMSGGG
I
TY
LL
E
K
AREKSNA
K
MIVIDPRY
T
DTAA
--
GREDEWLPIRPGTD
A
AL
VA
GIAWVLI
N
EN
L
VDQPFLDKYCVGYDEKTLPA
D
AP
K
N
G
HYKAYILGEG
D
D
K
TAKTP
Q
WA
S
Q
ITGIP
VD
R
IIKLAREIG
T
AKPAYICQGWGPQRQ
A
NGE
L
T
A
RAIAML
PI
LTGNVGI
S
GGNSG
-----------
A
RE
S
TYTITI
E
R
LP
V
L
D
NPVKT
S
IS
C
F
S
WTDAIDHG
PQ
MTAIR
-----
DGVR
---------
GK
D
KLDVPIKFIW
N
YAGNTL
V
NQH
S
DIN
K
THE
I
LQD
E
SKCEMIVVIE
N
FMT
S
SAKYADILLPDLM
TV
EQED
I
I
PNDY
AGNMGY
L
I
FL
QP
V
TS
E
KFERKPIYW
I
LSEVAKRLGPDVYQ
K
FTEGR
T
Q
EQ
WL
Q
H
LY
----
AK
ML
A
K
D
P
A
L
P
S
Y
D
E
L
K
KM
GI
Y
---
KRK
D
PN
G
H
F
VAY
K
AFR
D
DP
E
ANPLKTPSGKIEIYS
SK
LA
E
IA
-------
R
TWEL
E
KDE
V
I
S
PLP
V
Y
AST
F
E
GWD
S
P
E
R
SA
F
PLQL
F
GFHYK
S
RTHS
T
YGNID
V
LK
A
---
ACRQEVWINPIDAQ
K
RGIANGD
M
VRVFN
H
RGE
V
R
LP
AKVTPRILPGV
S
A
M
GQGAW
H
E
A
N
M
S
GD
K
I
DHGG
C
V
N
T
LT
T
L
RPSP
-
LAKGNP
Q
H
T
NLV
E
IEK
fig|364106.8.peg.1820
Escherichia coli UTI89 (10-807/808)
ISRR
T
L
V
K
S
T
AIGSLALA
AGG
F
S
LPF
T
--
L
R
S
A
E
A
A
V
-
QQ
A
N
EK
V
VWG
A
C
S
VNCGSRCALRLHVKD
NE
V
T
WVE
T
D
N
TG
S
D
E
Y
-
GNHQVRACLRGRSIRR
-----
RINHP
----
DRL
N
YPMKRVGKRGEGKFERISWDEALDTI
ASS
L
K
KT
V
K
Q
YGNEAV
Y
IQ
Y
S
S
G
IV
GGN
M
T
R
S
SPS
A
SA
-
VK
RLMN
CY
GG
S
L
NQ
YGSYSTAQIS
C
AMPY
TY
GS
-----
NDGNS
T
T
DIENSKLVVMFGNNPAET
------
RMSGGG
I
TY
LL
E
K
AREKSNA
K
MIVIDPRY
T
DTAA
--
GREDEWLPIRPGTD
A
AL
VA
GIAWVLI
N
EN
L
VDQPFLDKYCVGYDEKTLPA
D
AP
K
N
G
HYKAYILGEG
D
D
K
TAKTP
Q
WA
S
Q
ITGIP
VD
R
IIKLAREIG
T
AKPAYICQGWGPQRQ
A
NGE
L
T
A
RAIAML
PI
LTGNVGI
S
GGNSG
-----------
A
RE
S
TYTITI
E
R
LP
V
L
D
NPVKT
S
IS
C
F
S
WTDAIDHG
PQ
MTAIR
-----
DGVR
---------
GK
D
KLDVPIKFIW
N
YAGNTL
V
NQH
S
DIN
K
THE
I
LQD
E
SKCEMIVVIE
N
FMT
S
SAKYADILLPDLM
TV
EQED
I
I
PNDY
AGNMGY
L
I
FL
QP
V
TS
E
KFERKPIYW
I
LSEVAKRLGPDVYQ
K
FTEGR
T
Q
EQ
WL
Q
H
LY
----
AK
ML
A
K
D
P
A
L
P
S
Y
D
E
L
K
KM
GI
Y
---
KRK
D
PN
G
H
F
VAY
K
AFR
D
DP
E
ANPLKTPSGKIEIYS
SK
LA
E
IA
-------
R
TWEL
E
KDE
V
I
S
PLP
V
Y
AST
F
E
GWD
S
P
E
R
SA
F
PLQL
F
GFHYK
S
RTHS
T
YGNID
V
LK
A
---
ACRQEVWINPIDAQ
K
RGIANGD
M
VRVFN
H
RGE
V
R
LP
AKVTPRILPGV
S
A
M
GQGAW
H
E
A
N
M
S
GD
K
I
DHGG
C
V
N
T
LT
T
L
RPSP
-
LAKGNP
Q
H
T
NLV
E
IEK
fig|670897.3.peg.2337
Escherichia coli 2362-75 (10-807/808)
ISRR
T
L
V
K
S
T
AIGSLALA
AGG
F
S
LPF
T
--
L
R
S
A
E
A
A
V
-
QQ
A
N
EK
V
VWG
A
C
S
VNCGSRCALRLHVKD
NE
V
T
WVE
T
D
N
TG
S
D
E
Y
-
GNHQVRACLRGRSIRR
-----
RINHP
----
DRL
N
YPMKRVGKRGEGKFERISWDEALDTI
ASS
L
K
KT
V
K
Q
YGNEAV
Y
IQ
Y
S
S
G
IV
GGN
M
T
R
S
SPS
A
SA
-
VK
RLMN
CY
GG
S
L
NQ
YGSYSTAQIS
C
AMPY
TY
GS
-----
NDGNS
T
T
DIENSKLVVMFGNNPAET
------
RMSGGG
I
TY
LL
E
K
AREKSNA
K
MIVIDPRY
T
DTAA
--
GREDEWLPIRPGTD
A
AL
VA
GIAWVLI
N
EN
L
VDQPFLDKYCVGYDEKTLPA
D
AP
K
N
G
HYKAYILGEG
D
D
K
TAKTP
Q
WA
S
Q
ITGIP
VD
R
IIKLAREIG
T
AKPAYICQGWGPQRQ
A
NGE
L
T
A
RAIAML
PI
LTGNVGI
S
GGNSG
-----------
A
RE
S
TYTITI
E
R
LP
V
L
D
NPVKT
S
IS
C
F
S
WTDAIDHG
PQ
MTAIR
-----
DGVR
---------
GK
D
KLDVPIKFIW
N
YAGNTL
V
NQH
S
DIN
K
THE
I
LQD
E
SKCEMIVVIE
N
FMT
S
SAKYADILLPDLM
TV
EQED
I
I
PNDY
AGNMGY
L
I
FL
QP
V
TS
E
KFERKPIYW
I
LSEVAKRLGPDVYQ
K
FTEGR
T
Q
EQ
WL
Q
H
LY
----
AK
ML
A
K
D
P
A
L
P
S
Y
D
E
L
K
KM
GI
Y
---
KRK
D
PN
G
H
F
VAY
K
AFR
D
DP
E
ANPLKTPSGKIEIYS
SK
LA
E
IA
-------
R
TWEL
E
KDE
V
I
S
PLP
V
Y
AST
F
E
GWD
S
P
E
HSA
F
PLQL
F
GFHYK
S
RTHS
T
YGNID
V
LK
A
---
ACRQEVWINPIDAQ
K
RGIANGD
M
VRVFN
H
RGE
V
R
LP
AKVTPRILPGV
S
A
M
GQGAW
H
E
A
N
M
S
GD
K
I
DHGG
C
V
N
T
LT
T
L
RPSP
-
LAKGNP
Q
H
T
NLV
E
IEK
fig|216593.1.peg.355
Escherichia coli E2348/69 (10-807/808)
ISRR
T
L
V
K
S
T
AIGSLALA
AGG
F
S
LPF
T
--
L
R
S
A
E
A
A
V
-
QQ
A
N
EK
V
VWG
A
C
S
VNCGSRCALRLHVKD
NE
V
T
WVE
T
D
N
TG
S
D
E
Y
-
GNHQVRACLRGRSIRR
-----
RINHP
----
DRL
N
YPMKRVGKRGEGKFERISWDEALDTI
ASS
L
K
KT
V
K
Q
YGNEAV
Y
IQ
Y
S
S
G
IV
GGN
M
T
R
S
SPS
A
SA
-
VK
RLMN
CY
GG
S
L
NQ
YGSYSTAQIS
C
AMPY
TY
GS
-----
NDGNS
T
T
DIENSKLVVMFGNNPAET
------
RMSGGG
I
TY
LL
E
K
AREKSNA
K
MIVIDPRY
T
DTAA
--
GREDEWLPIRPGTD
A
AL
VA
GIAWVLI
N
EN
L
VDQPFLDKYCVGYDEKTLPA
D
AP
K
N
G
HYKAYILGEG
D
D
K
TAKTP
Q
WA
S
Q
ITGIP
VD
R
IIKLAREIG
T
AKPAYICQGWGPQRQ
A
NGE
L
T
A
RAIAML
PI
LTGNVGI
S
GGNSG
-----------
A
RE
S
TYTITI
E
R
LP
V
L
D
NPVKT
S
IS
C
F
S
WTDAIDHG
PQ
MTAIR
-----
DGVR
---------
GK
D
KLDVPIKFIW
N
YAGNTL
V
NQH
S
DIN
K
THE
I
LQD
E
SKCEMIVVIE
N
FMT
S
SAKYADILLPDLM
TV
EQED
I
I
PNDY
AGNMGY
L
I
FL
QP
V
TS
E
KFERKPIYW
I
LSEVAKRLGPDVYQ
K
FTEGR
T
Q
EQ
WL
Q
H
LY
----
AK
ML
A
K
D
P
A
L
P
S
Y
D
E
L
K
KM
GI
Y
---
KRK
D
PN
G
H
F
VAY
K
AFR
D
DP
E
ANPLKTPSGKIEIYS
SK
LA
E
IA
-------
R
TWEL
E
KDE
V
I
S
PLP
V
Y
AST
F
E
GWD
S
P
E
HSA
F
PLQL
F
GFHYK
S
RTHS
T
YGNID
V
LK
A
---
ACRQEVWINPIDAQ
K
RGIANGD
M
VRVFN
H
RGE
V
R
LP
AKVTPRILPGV
S
A
M
GQGAW
H
E
A
N
M
S
GD
K
I
DHGG
C
V
N
T
LT
T
L
RPSP
-
LAKGNP
Q
H
T
NLV
E
IEK
fig|574521.7.peg.1708
Escherichia coli O127:H6 str. E2348/69 (10-807/808)
ISRR
T
L
V
K
S
T
AIGSLALA
AGG
F
S
LPF
T
--
L
R
S
A
E
A
A
V
-
QQ
A
N
EK
V
VWG
A
C
S
VNCGSRCALRLHVKD
NE
V
T
WVE
T
D
N
TG
S
D
E
Y
-
GNHQVRACLRGRSIRR
-----
RINHP
----
DRL
N
YPMKRVGKRGEGKFERISWDEALDTI
ASS
L
K
KT
V
K
Q
YGNEAV
Y
IQ
Y
S
S
G
IV
GGN
M
T
R
S
SPS
A
SA
-
VK
RLMN
CY
GG
S
L
NQ
YGSYSTAQIS
C
AMPY
TY
GS
-----
NDGNS
T
T
DIENSKLVVMFGNNPAET
------
RMSGGG
I
TY
LL
E
K
AREKSNA
K
MIVIDPRY
T
DTAA
--
GREDEWLPIRPGTD
A
AL
VA
GIAWVLI
N
EN
L
VDQPFLDKYCVGYDEKTLPA
D
AP
K
N
G
HYKAYILGEG
D
D
K
TAKTP
Q
WA
S
Q
ITGIP
VD
R
IIKLAREIG
T
AKPAYICQGWGPQRQ
A
NGE
L
T
A
RAIAML
PI
LTGNVGI
S
GGNSG
-----------
A
RE
S
TYTITI
E
R
LP
V
L
D
NPVKT
S
IS
C
F
S
WTDAIDHG
PQ
MTAIR
-----
DGVR
---------
GK
D
KLDVPIKFIW
N
YAGNTL
V
NQH
S
DIN
K
THE
I
LQD
E
SKCEMIVVIE
N
FMT
S
SAKYADILLPDLM
TV
EQED
I
I
PNDY
AGNMGY
L
I
FL
QP
V
TS
E
KFERKPIYW
I
LSEVAKRLGPDVYQ
K
FTEGR
T
Q
EQ
WL
Q
H
LY
----
AK
ML
A
K
D
P
A
L
P
S
Y
D
E
L
K
KM
GI
Y
---
KRK
D
PN
G
H
F
VAY
K
AFR
D
DP
E
ANPLKTPSGKIEIYS
SK
LA
E
IA
-------
R
TWEL
E
KDE
V
I
S
PLP
V
Y
AST
F
E
GWD
S
P
E
HSA
F
PLQL
F
GFHYK
S
RTHS
T
YGNID
V
LK
A
---
ACRQEVWINPIDAQ
K
RGIANGD
M
VRVFN
H
RGE
V
R
LP
AKVTPRILPGV
S
A
M
GQGAW
H
E
A
N
M
S
GD
K
I
DHGG
C
V
N
T
LT
T
L
RPSP
-
LAKGNP
Q
H
T
NLV
E
IEK
fig|439855.10.peg.1773
Escherichia coli SMS-3-5 (10-807/808)
ISRR
T
L
V
K
S
T
AIGSLALA
AGG
F
S
LPF
T
--
L
R
S
S
AA
A
V
-
QQ
A
S
EK
V
VWG
A
C
S
VNCGSRCALRLHVKD
NE
V
T
WVE
T
D
N
TG
N
D
E
Y
-
GN
Q
QVRACLRGRSIRR
-----
RINHP
----
DRL
N
YPMKRVGKRGEGKFERISWDEALDTI
ASS
L
K
KT
V
E
Q
YGNEAV
Y
IQ
Y
S
S
G
IV
GGN
M
T
R
S
SPS
A
SA
-
VK
RLMN
CY
GG
S
L
NQ
YGSYSTAQIS
C
AMPY
TY
GS
-----
NDGNS
T
T
DIENSKLVVMFGNNPAET
------
RMSGGG
I
TY
LL
E
K
AREKSNA
K
MIVIDPRY
T
DTAA
--
GREDEWLPIRPGTD
A
AL
VA
GIAWVLI
N
EN
L
VDQPFLDKYCVGYDEKTLPA
D
AP
K
N
G
HYKAYILGEG
D
D
K
TAKTP
Q
WA
S
Q
ITGIP
VD
R
IIKLAREIG
T
AKPAYICQGWGPQRQ
A
NGE
L
T
A
RAIAML
PI
LTGNVGI
S
GGNSG
-----------
A
RE
S
TYTITI
E
R
LP
V
L
D
NPVKT
S
IS
C
F
S
WTDAIDHG
PQ
MTAIR
-----
DGVR
---------
GK
D
KLDVPIKFIW
N
YAGNTL
V
NQH
S
DIN
K
THE
I
LQD
E
SKCEMIVVIE
N
FMT
S
SAKYADILLPDLM
TV
EQED
I
I
PNDY
AGNMGY
L
I
FL
QP
V
TS
E
KFERKPIYW
I
LSEVAKRLGPDVYQ
K
FTEGR
T
Q
EQ
WL
Q
H
LY
----
AK
ML
A
K
D
P
A
L
P
S
Y
D
E
L
K
KM
GI
Y
---
KRK
D
PN
G
H
F
VAY
K
AFR
E
DP
E
ANPLKTPSGKIEIYS
NR
LA
E
IA
-------
R
TWEL
E
KDE
V
I
S
PLP
V
Y
AST
F
E
GWD
S
P
E
R
R
T
F
PLQL
F
GFHYK
S
RTHS
T
YGNID
V
LK
A
---
ACRQEVWINPIDAQ
K
RGIANGD
M
VRVFN
H
RGE
V
R
LP
AKVTPRILPGV
S
A
M
GQGAW
H
E
A
N
M
S
GD
K
I
DHGG
C
V
N
T
LT
T
L
RPSP
-
LAKGNP
Q
H
T
NLV
E
IEK
fig|525281.3.peg.975
Escherichia coli 83972 (5-797/798)
ISRR
S
L
M
K
T
SA
L
GSLALA
SSA
F
T
LPF
S
QM
VR
A
A
Q
APV
-
E-
-
-
EK
A
VW
S
S
C
T
VNCGSRC
L
LRLHVKD
DT
V
Y
WVE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRR
-----
R
M
NHP
----
DRL
K
YPMKRVGKRGEGKFERISWDEALDTI
SDN
L
R
RI
L
K
D
YGNEAV
H
VL
Y
G
T
G
VD
GGN
I
T
N
S
---
-
NV
-
PY
RLMN
SC
GG
F
L
SR
YGSYSTAQIS
A
AM
S
Y
MF
G
A
-----
NDGNSP
D
DI
A
N
T
KLVVMFGNNPAET
------
RMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIVIDPRY
N
DTAA
--
GREDEWLPIRPGTD
G
AL
AC
A
IAWVLITEN
M
VDQPFLDKYCVGYDEKTLPA
N
AP
R
N
A
HYKAYILGEG
P
D
G
I
AKTP
E
WAA
K
IT
S
IP
AE
K
II
Q
LAREIG
S
AKPAYICQGWGPQR
H
S
NGEQT
S
RAIAML
SV
LTGNVGI
N
GGNSG
-----------
V
REG
SWDLGV
E
W
LP
M
L
E
NPVKTQIS
V
F
T
WTDAIDHG
TE
MTA
P
R
-----
DGVR
---------
GKEKLDVPIKF
L
W
C
YA
S
NTL
I
NQH
G
DIN
H
THE
V
LQD
D
SKCEMIV
G
I
D
H
FMTASAKY
C
DILLPDLM
PT
EQEDLI
SHES
AGNMGY
V
I
LA
QPATS
A
KFERKPIYW
M
LSEVAKRLGPDVYQ
T
FTEGR
S
Q
HE
W
I
K
Y
L
H
----
AK
TK
E
R
N
P
E
MP
D
Y
E
E
M
K
TI
GI
F
---
K
K
K
C
P
E
EHYVA
F
R
AFR
V
DP
Q
ANPLKTPSGKIEIYS
ER
LAKIA
-------
D
TWEL
K
KDE
I
I
H
PLP
A
Y
TPG
FDGWD
D
P
L
R
K
T
Y
PLQL
T
GFHYK
A
RTHS
S
YGNID
V
L
Q
Q
---
AC
P
QEVWINPIDAQ
A
RGI
RH
GD
T
VRVFN
N
N
GE
M
L
IA
AKVTPRILPGV
T
A
I
GQGAW
L
K
A
D
M
F
GD
R
V
DHGGS
I
N
I
LT
S
H
RPSP
-
LAKGNP
S
HSNLV
Q
IEK
fig|655817.3.peg.1869
Escherichia coli ABU 83972 (15-807/808)
ISRR
S
L
M
K
T
SA
L
GSLALA
SSA
F
T
LPF
S
QM
VR
A
A
Q
APV
-
E-
-
-
EK
A
VW
S
S
C
T
VNCGSRC
L
LRLHVKD
DT
V
Y
WVE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRR
-----
R
M
NHP
----
DRL
K
YPMKRVGKRGEGKFERISWDEALDTI
SDN
L
R
RI
L
K
D
YGNEAV
H
VL
Y
G
T
G
VD
GGN
I
T
N
S
---
-
NV
-
PY
RLMN
SC
GG
F
L
SR
YGSYSTAQIS
A
AM
S
Y
MF
G
A
-----
NDGNSP
D
DI
A
N
T
KLVVMFGNNPAET
------
RMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIVIDPRY
N
DTAA
--
GREDEWLPIRPGTD
G
AL
AC
A
IAWVLITEN
M
VDQPFLDKYCVGYDEKTLPA
N
AP
R
N
A
HYKAYILGEG
P
D
G
I
AKTP
E
WAA
K
IT
S
IP
AE
K
II
Q
LAREIG
S
AKPAYICQGWGPQR
H
S
NGEQT
S
RAIAML
SV
LTGNVGI
N
GGNSG
-----------
V
REG
SWDLGV
E
W
LP
M
L
E
NPVKTQIS
V
F
T
WTDAIDHG
TE
MTA
P
R
-----
DGVR
---------
GKEKLDVPIKF
L
W
C
YA
S
NTL
I
NQH
G
DIN
H
THE
V
LQD
D
SKCEMIV
G
I
D
H
FMTASAKY
C
DILLPDLM
PT
EQEDLI
SHES
AGNMGY
V
I
LA
QPATS
A
KFERKPIYW
M
LSEVAKRLGPDVYQ
T
FTEGR
S
Q
HE
W
I
K
Y
L
H
----
AK
TK
E
R
N
P
E
MP
D
Y
E
E
M
K
TI
GI
F
---
K
K
K
C
P
E
EHYVA
F
R
AFR
V
DP
Q
ANPLKTPSGKIEIYS
ER
LAKIA
-------
D
TWEL
K
KDE
I
I
H
PLP
A
Y
TPG
FDGWD
D
P
L
R
K
T
Y
PLQL
T
GFHYK
A
RTHS
S
YGNID
V
L
Q
Q
---
AC
P
QEVWINPIDAQ
A
RGI
RH
GD
T
VRVFN
N
N
GE
M
L
IA
AKVTPRILPGV
T
A
I
GQGAW
L
K
A
D
M
F
GD
R
V
DHGGS
I
N
I
LT
S
H
RPSP
-
LAKGNP
S
HSNLV
Q
IEK
fig|655817.3.peg.1870
Escherichia coli ABU 83972 (5-797/798)
ISRR
S
L
M
K
T
SA
L
GSLALA
SSA
F
T
LPF
S
QM
VR
A
A
Q
APV
-
E-
-
-
EK
A
VW
S
S
C
T
VNCGSRC
L
LRLHVKD
DT
V
Y
WVE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRR
-----
R
M
NHP
----
DRL
K
YPMKRVGKRGEGKFERISWDEALDTI
SDN
L
R
RI
L
K
D
YGNEAV
H
VL
Y
G
T
G
VD
GGN
I
T
N
S
---
-
NV
-
PY
RLMN
SC
GG
F
L
SR
YGSYSTAQIS
A
AM
S
Y
MF
G
A
-----
NDGNSP
D
DI
A
N
T
KLVVMFGNNPAET
------
RMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIVIDPRY
N
DTAA
--
GREDEWLPIRPGTD
G
AL
AC
A
IAWVLITEN
M
VDQPFLDKYCVGYDEKTLPA
N
AP
R
N
A
HYKAYILGEG
P
D
G
I
AKTP
E
WAA
K
IT
S
IP
AE
K
II
Q
LAREIG
S
AKPAYICQGWGPQR
H
S
NGEQT
S
RAIAML
SV
LTGNVGI
N
GGNSG
-----------
V
REG
SWDLGV
E
W
LP
M
L
E
NPVKTQIS
V
F
T
WTDAIDHG
TE
MTA
P
R
-----
DGVR
---------
GKEKLDVPIKF
L
W
C
YA
S
NTL
I
NQH
G
DIN
H
THE
V
LQD
D
SKCEMIV
G
I
D
H
FMTASAKY
C
DILLPDLM
PT
EQEDLI
SHES
AGNMGY
V
I
LA
QPATS
A
KFERKPIYW
M
LSEVAKRLGPDVYQ
T
FTEGR
S
Q
HE
W
I
K
Y
L
H
----
AK
TK
E
R
N
P
E
MP
D
Y
E
E
M
K
TI
GI
F
---
K
K
K
C
P
E
EHYVA
F
R
AFR
V
DP
Q
ANPLKTPSGKIEIYS
ER
LAKIA
-------
D
TWEL
K
KDE
I
I
H
PLP
A
Y
TPG
FDGWD
D
P
L
R
K
T
Y
PLQL
T
GFHYK
A
RTHS
S
YGNID
V
L
Q
Q
---
AC
P
QEVWINPIDAQ
A
RGI
RH
GD
T
VRVFN
N
N
GE
M
L
IA
AKVTPRILPGV
T
A
I
GQGAW
L
K
A
D
M
F
GD
R
V
DHGGS
I
N
I
LT
S
H
RPSP
-
LAKGNP
S
HSNLV
Q
IEK
fig|753642.3.peg.1575
Escherichia coli NC101 (5-797/798)
ISRR
S
L
M
K
T
SA
L
GSLALA
SSA
F
T
LPF
S
QM
VR
A
A
Q
APV
-
E-
-
-
EK
A
VW
S
S
C
T
VNCGSRC
L
LRLHVKD
DT
V
Y
WVE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRR
-----
R
M
NHP
----
DRL
K
YPMKRVGKRGEGKFERISWDEALDTI
SDN
L
R
RI
L
K
D
YGNEAV
H
VL
Y
G
T
G
VD
GGN
I
T
N
S
---
-
NV
-
PY
RLMN
SC
GG
F
L
SR
YGSYSTAQIS
A
AM
S
Y
MF
G
A
-----
NDGNSP
D
DI
A
N
T
KLVVMFGNNPAET
------
RMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIVIDPRY
N
DTAA
--
GREDEWLPIRPGTD
G
AL
AC
A
IAWVLITEN
M
VDQPFLDKYCVGYDEKTLPA
N
AP
R
N
A
HYKAYILGEG
P
D
G
I
AKTP
E
WAA
K
IT
S
IP
AE
K
II
Q
LA
L
EIG
S
AKPAYICQGWGPQR
H
S
NGEQT
S
RAIAML
SV
LTGNVGI
N
GGNSG
-----------
V
REG
SWDLGV
E
W
LP
M
L
E
NPVKTQIS
V
F
T
WTDAIDHG
TE
MTA
P
R
-----
DGVR
---------
GKEKLDVPIKF
L
W
C
YA
S
NTL
I
NQH
G
DIN
H
THE
V
LQD
D
SKCEMIV
G
I
D
H
FMTASAKY
C
DILLPDLM
PT
EQEDLI
SHES
AGNMGY
V
I
LA
QPATS
A
KFERKPIYW
M
LSEVAKRLGPDVYQ
T
FTEGR
S
Q
HE
W
I
K
Y
L
H
----
AK
TK
E
R
N
S
E
MP
D
Y
E
E
M
K
TT
GI
F
---
K
K
K
C
P
E
EHYVA
F
R
AFR
V
DP
Q
ANPLKTPSGKIEIYS
ER
LAKIA
-------
D
TWEL
K
KDE
I
I
H
PLP
A
Y
TPG
FDGWD
D
P
L
R
K
T
Y
PLQL
T
GFHYK
A
RTHS
S
YGNID
V
L
Q
Q
---
AC
P
QEVWINPIDAQ
A
RGI
RH
GD
T
VRVFN
N
N
GE
M
L
IA
AKVTPRILPGV
T
A
I
GQGAW
L
K
A
D
M
F
GD
R
V
DHGGS
I
N
I
LT
S
H
RPSP
-
LAKGNP
S
HSNLV
Q
IEK
fig|199310.1.peg.1916
Escherichia coli CFT073 (15-807/808)
ISRR
S
L
M
K
T
SA
L
GSLALA
SSA
F
T
LPF
S
QM
VR
A
A
Q
APV
-
E-
-
-
EK
A
VW
S
S
C
T
VNCGSRC
L
LRLHVKD
DT
V
Y
WVE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRR
-----
R
M
NHP
----
DRL
K
YPMKRVGKRGEGKFERISWDEALDTI
SDN
L
R
RI
L
K
D
YGNEAV
H
VL
Y
G
T
G
VD
GGN
I
T
N
S
---
-
NV
-
PY
RLMN
SC
GG
F
L
SR
YGSYSTAQIS
A
AM
S
Y
MF
G
A
-----
NDGNSP
D
DI
A
N
T
KLVVMFGNNPAET
------
RMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIVIDPRY
N
DTAA
--
GREDEWLPIRPGTD
G
AL
AC
A
IAWVLITEN
M
VDQPFLDKYCVGYDEKTLPA
N
AP
R
N
A
HYKAYILGEG
P
D
G
I
AKTP
E
WAA
K
IT
S
IP
AE
K
II
Q
LAREIG
S
AKPAYICQGWGPQR
H
S
NGEQT
S
RAIAML
SV
LTGNVGI
N
GGNSG
-----------
V
REG
SWDLGV
E
W
LP
M
L
E
NPVKTQIS
V
F
T
WTDAIDHG
TE
MTA
P
R
-----
DGVR
---------
GKEKLDVPIKF
L
W
C
YA
S
NTL
I
NQH
G
DIN
H
THE
V
LQD
D
SKCEMIV
G
I
D
H
FMTASAKY
C
DILLPDLM
PT
EQEDLI
SHES
AGNMGY
V
I
LA
QPATS
A
KFERKPIYW
M
LSEVAKRLGPDVYQ
T
FTEGR
S
Q
HE
W
I
K
Y
L
H
----
AK
TK
E
R
N
P
E
MP
D
Y
E
E
M
K
TT
GI
F
---
K
K
K
C
P
E
EHYVA
F
R
AFR
V
DP
Q
ANPLKTPSGKIEIYS
ER
LAKIA
-------
D
TWEL
K
KDE
I
I
H
PLP
A
Y
TPG
FDGWD
D
P
L
R
K
T
Y
PLQL
T
GFHYK
A
RTHS
S
YGNID
V
L
Q
Q
---
AC
P
QEVWINPIDAQ
A
RGI
RH
GD
T
VRVFN
N
N
GE
M
L
IA
AKVTPRILPGV
T
A
I
GQGAW
L
K
A
D
M
F
GD
R
V
DHGGS
I
N
I
LT
S
H
RPSP
-
LAKGNP
S
HSNLV
Q
IEK
fig|199310.4.peg.1847
Escherichia coli CFT073 (5-797/798)
ISRR
S
L
M
K
T
SA
L
GSLALA
SSA
F
T
LPF
S
QM
VR
A
A
Q
APV
-
E-
-
-
EK
A
VW
S
S
C
T
VNCGSRC
L
LRLHVKD
DT
V
Y
WVE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRR
-----
R
M
NHP
----
DRL
K
YPMKRVGKRGEGKFERISWDEALDTI
SDN
L
R
RI
L
K
D
YGNEAV
H
VL
Y
G
T
G
VD
GGN
I
T
N
S
---
-
NV
-
PY
RLMN
SC
GG
F
L
SR
YGSYSTAQIS
A
AM
S
Y
MF
G
A
-----
NDGNSP
D
DI
A
N
T
KLVVMFGNNPAET
------
RMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIVIDPRY
N
DTAA
--
GREDEWLPIRPGTD
G
AL
AC
A
IAWVLITEN
M
VDQPFLDKYCVGYDEKTLPA
N
AP
R
N
A
HYKAYILGEG
P
D
G
I
AKTP
E
WAA
K
IT
S
IP
AE
K
II
Q
LAREIG
S
AKPAYICQGWGPQR
H
S
NGEQT
S
RAIAML
SV
LTGNVGI
N
GGNSG
-----------
V
REG
SWDLGV
E
W
LP
M
L
E
NPVKTQIS
V
F
T
WTDAIDHG
TE
MTA
P
R
-----
DGVR
---------
GKEKLDVPIKF
L
W
C
YA
S
NTL
I
NQH
G
DIN
H
THE
V
LQD
D
SKCEMIV
G
I
D
H
FMTASAKY
C
DILLPDLM
PT
EQEDLI
SHES
AGNMGY
V
I
LA
QPATS
A
KFERKPIYW
M
LSEVAKRLGPDVYQ
T
FTEGR
S
Q
HE
W
I
K
Y
L
H
----
AK
TK
E
R
N
P
E
MP
D
Y
E
E
M
K
TT
GI
F
---
K
K
K
C
P
E
EHYVA
F
R
AFR
V
DP
Q
ANPLKTPSGKIEIYS
ER
LAKIA
-------
D
TWEL
K
KDE
I
I
H
PLP
A
Y
TPG
FDGWD
D
P
L
R
K
T
Y
PLQL
T
GFHYK
A
RTHS
S
YGNID
V
L
Q
Q
---
AC
P
QEVWINPIDAQ
A
RGI
RH
GD
T
VRVFN
N
N
GE
M
L
IA
AKVTPRILPGV
T
A
I
GQGAW
L
K
A
D
M
F
GD
R
V
DHGGS
I
N
I
LT
S
H
RPSP
-
LAKGNP
S
HSNLV
Q
IEK
fig|749546.3.peg.3878
Escherichia coli MS 185-1 (5-797/798)
ISRR
S
L
M
K
T
SA
L
GSLALA
SSA
F
T
LPF
S
QM
VR
A
A
Q
APV
-
E-
-
-
EK
A
VW
S
S
C
T
VNCGSRC
L
LRLHVKD
DT
V
Y
WVE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRR
-----
R
M
NHP
----
DRL
K
YPMKRVGKRGEGKFERISWDEALDTI
SDN
L
R
RI
L
K
D
YGNEAV
H
VL
Y
G
T
G
VD
GGN
I
T
N
S
---
-
NV
-
PY
RLMN
SC
GG
F
L
SR
YGSYSTAQIS
A
AM
S
Y
MF
G
A
-----
NDGNSP
D
DI
A
N
T
KLVVMFGNNPAET
------
RMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIVIDPRY
N
DTAA
--
GREDEWLPIRPGTD
G
AL
AC
A
IAWVLITEN
M
VDQPFLDKYCVGYDEKTLPA
N
AP
R
N
A
HYKAYILGEG
P
D
G
I
AKTP
E
WAA
K
IT
S
IP
AE
K
II
Q
LAREIG
S
AKPAYICQGWGPQR
H
S
NGEQT
S
RAIAML
SV
LTGNVGI
N
GGNSG
-----------
V
REG
SWDLGV
E
W
LP
M
L
E
NPVKTQIS
V
F
T
WTDAIDHG
TE
MTA
P
R
-----
DGVR
---------
GKEKLDVPIKF
L
W
C
YA
S
NTL
I
NQH
G
DIN
H
THE
V
LQD
D
SKCEMIV
G
I
D
H
FMTASAKY
C
DILLPDLM
PT
EQEDLI
SHES
AGNMGY
V
I
LA
QPATS
A
KFERKPIYW
M
LSEVAKRLGPDVYQ
T
FTEGR
S
Q
HE
W
I
K
Y
L
H
----
AK
TK
E
R
N
P
E
MP
D
Y
E
E
M
K
TT
GI
F
---
K
K
K
C
P
E
EHYVA
F
R
AFR
V
DP
Q
ANPLKTPSGKIEIYS
ER
LAKIA
-------
D
TWEL
K
KDE
I
I
H
PLP
A
Y
TPG
FDGWD
D
P
L
R
K
T
Y
PLQL
T
GFHYK
A
RTHS
S
YGNID
V
L
Q
Q
---
AC
P
QEVWINPIDAQ
A
RGI
RH
GD
T
VRVFN
N
N
GE
M
L
IA
AKVTPRILPGV
T
A
I
GQGAW
L
K
A
D
M
F
GD
R
V
DHGGS
I
N
I
LT
S
H
RPSP
-
LAKGNP
S
HSNLV
Q
IEK
fig|749528.3.peg.3856
Escherichia coli MS 45-1 (5-797/798)
ISRR
S
L
M
K
T
SA
L
GSLALA
SSA
F
T
LPF
S
QM
VR
A
A
Q
APV
-
E-
-
-
EK
A
VW
S
S
C
T
VNCGSRC
L
LRLHVKD
DT
V
Y
WVE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRR
-----
R
M
NHP
----
DRL
K
YPMKRVGKRGEGKFERISWDEALDTI
SDN
L
R
RI
L
K
D
YGNEAV
H
VL
Y
G
T
G
VD
GGN
I
T
N
S
---
-
NV
-
PY
RLMN
SC
GG
F
L
SR
YGSYSTAQIS
A
AM
S
Y
MF
G
A
-----
NDGNSP
D
DI
A
N
T
KLVVMFGNNPAET
------
RMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIVIDPRY
N
DTAA
--
GREDEWLPIRPGTD
G
AL
AC
A
IAWVLITEN
M
VDQPFLDKYCVGYDEKTLPA
N
AP
R
N
A
HYKAYILGEG
P
D
G
I
AKTP
E
WAA
K
IT
S
IP
AE
K
II
Q
LAREIG
S
AKPAYICQGWGPQR
H
S
NGEQT
S
RAIAML
SV
LTGNVGI
N
GGNSG
-----------
V
REG
SWDLGV
E
W
LP
M
L
E
NPVKTQIS
V
F
T
WTDAIDHG
TE
MTA
P
R
-----
DGVR
---------
GKEKLDVPIKF
L
W
C
YA
S
NTL
I
NQH
G
DIN
H
THE
V
LQD
D
SKCEMIV
G
I
D
H
FMTASAKY
C
DILLPDLM
PT
EQEDLI
SHES
AGNMGY
V
I
LA
QPATS
A
KFERKPIYW
M
LSEVAKRLGPDVYQ
T
FTEGR
S
Q
HE
W
I
K
Y
L
H
----
AK
TK
E
R
N
P
E
MP
D
Y
E
E
M
K
TT
GI
F
---
K
K
K
C
P
E
EHYVA
F
R
AFR
V
DP
Q
ANPLKTPSGKIEIYS
ER
LAKIA
-------
D
TWEL
K
KDE
I
I
H
PLP
A
Y
TPG
FDGWD
D
P
L
R
K
T
Y
PLQL
T
GFHYK
A
RTHS
S
YGNID
V
L
Q
Q
---
AC
P
QEVWINPIDAQ
A
RGI
RH
GD
T
VRVFN
N
N
GE
M
L
IA
AKVTPRILPGV
T
A
I
GQGAW
L
K
A
D
M
F
GD
R
V
DHGGS
I
N
I
LT
S
H
RPSP
-
LAKGNP
S
HSNLV
Q
IEK
fig|670897.3.peg.2336
Escherichia coli 2362-75 (5-797/798)
ISRR
S
L
M
K
T
SA
L
GSLALA
SSA
F
T
LPF
S
QM
VR
A
A
Q
APV
-
E-
-
-
EK
A
VW
S
S
C
T
VNCGSRC
L
LRLHVKD
DT
V
Y
WVE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRR
-----
R
M
NHP
----
DRL
K
YPMKRVGKRGEGKFERISWDEALDTI
SDN
L
R
RI
L
K
D
YGNEAV
H
VL
Y
G
T
G
VD
GGN
I
T
N
S
---
-
NV
-
PY
RLMN
SC
GG
F
L
SR
YGSYSTAQIS
A
AM
S
Y
MF
G
A
-----
NDGNSP
D
DI
A
N
T
KLVVMFGNNPAET
------
RMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIVIDPRY
N
DTAA
--
GREDEWLPIRPGTD
G
AL
AC
A
IAWVLITEN
M
VDQPFLDKYCVGYDEKTLPA
N
AP
R
N
A
HYKAYILGEG
T
D
S
I
AKTP
E
WAA
K
IT
S
IP
AE
K
II
Q
LAREIG
S
AKPAYICQGWGPQR
H
S
NGEQT
S
RAIAML
SV
LTGNVGI
N
GGNSG
-----------
V
REG
SWDLGV
E
W
F
P
M
L
E
NPVKTQIS
V
F
T
WTDAIDHG
TE
MTA
T
R
-----
DGVR
---------
GKEKLDVPIKF
L
W
C
YA
S
NTL
I
NQH
G
DIN
H
THE
V
LQD
D
SKCEMIV
G
I
D
H
FMTASAKY
C
DILLPDLM
PT
EQEDLI
SHES
AGNMGY
V
I
LA
QPATS
A
KFERKPIYW
M
LSEVAKRLGPDVYQ
T
FTEGR
S
Q
HE
W
I
K
Y
L
H
----
AK
TK
E
R
N
P
E
MP
D
Y
E
E
M
K
TT
GI
F
---
K
K
K
C
P
E
EHYVA
F
R
AFR
E
DP
Q
ANPLKTPSGKIEIYS
ER
LAKIA
-------
D
TWEL
K
KDE
I
I
H
PLP
A
Y
TPG
FDGWD
D
P
L
R
K
T
Y
PLQL
T
GFHYK
A
RTHS
S
YGNID
V
L
Q
Q
---
AC
P
QEVWINPIDAQ
A
RGI
RH
GD
T
VRVFN
N
N
GE
M
L
IA
AKVTPRILPGV
T
A
I
GQGAW
L
K
A
D
M
F
GD
R
V
DHGGS
I
N
I
LT
S
H
RPSP
-
LAKGNP
S
HSNLV
Q
IEK
fig|216593.1.peg.356
Escherichia coli E2348/69 (15-807/808)
ISRR
S
L
M
K
T
SA
L
GSLALA
SSA
F
T
LPF
S
QM
VR
A
A
Q
APV
-
E-
-
-
EK
A
VW
S
S
C
T
VNCGSRC
L
LRLHVKD
DT
V
Y
WVE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRR
-----
R
M
NHP
----
DRL
K
YPMKRVGKRGEGKFERISWDEALDTI
SDN
L
R
RI
L
K
D
YGNEAV
H
VL
Y
G
T
G
VD
GGN
I
T
N
S
---
-
NV
-
PY
RLMN
SC
GG
F
L
SR
YGSYSTAQIS
A
AM
S
Y
MF
G
A
-----
NDGNSP
D
DI
A
N
T
KLVVMFGNNPAET
------
RMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIVIDPRY
N
DTAA
--
GREDEWLPIRPGTD
G
AL
AC
A
IAWVLITEN
M
VDQPFLDKYCVGYDEKTLPA
N
AP
R
N
A
HYKAYILGEG
T
D
S
I
AKTP
E
WAA
K
IT
S
IP
AE
K
II
Q
LAREIG
S
AKPAYICQGWGPQR
H
S
NGEQT
S
RAIAML
SV
LTGNVGI
N
GGNSG
-----------
V
REG
SWDLGV
E
W
F
P
M
L
E
NPVKTQIS
V
F
T
WTDAIDHG
TE
MTA
T
R
-----
DGVR
---------
GKEKLDVPIKF
L
W
C
YA
S
NTL
I
NQH
G
DIN
H
THE
V
LQD
D
SKCEMIV
G
I
D
H
FMTASAKY
C
DILLPDLM
PT
EQEDLI
SHES
AGNMGY
V
I
LA
QPATS
A
KFERKPIYW
M
LSEVAKRLGPDVYQ
T
FTEGR
S
Q
HE
W
I
K
Y
L
H
----
AK
TK
E
R
N
P
E
MP
D
Y
E
E
M
K
TT
GI
F
---
K
K
K
C
P
E
EHYVA
F
R
AFR
E
DP
Q
ANPLKTPSGKIEIYS
ER
LAKIA
-------
D
TWEL
K
KDE
I
I
H
PLP
A
Y
TPG
FDGWD
D
P
L
R
K
T
Y
PLQL
T
GFHYK
A
RTHS
S
YGNID
V
L
Q
Q
---
AC
P
QEVWINPIDAQ
A
RGI
RH
GD
T
VRVFN
N
N
GE
M
L
IA
AKVTPRILPGV
T
A
I
GQGAW
L
K
A
D
M
F
GD
R
V
DHGGS
I
N
I
LT
S
H
RPSP
-
LAKGNP
S
HSNLV
Q
IEK
fig|585397.7.peg.1776
Escherichia coli ED1a (5-797/798)
ISRR
S
L
M
K
T
SA
L
GSLALA
SSA
F
T
LPF
S
QM
VR
A
A
Q
APV
-
E-
-
-
EK
A
VW
S
S
C
T
VNCGSRC
L
LRLHVKD
DT
V
Y
WVE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRR
-----
R
M
NHP
----
DRL
K
YPMKRVGKRGEGKFERISWDEALDTI
SDN
L
R
RI
L
K
D
YGNEAV
H
VL
Y
G
T
G
VD
GGN
I
T
N
S
---
-
NV
-
PY
RLMN
SC
GG
F
L
SR
YGSYSTAQIS
A
AM
S
Y
MF
G
A
-----
NDGNSP
D
DI
A
N
T
KLVVMFGNNPAET
------
RMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIVIDPRY
N
DTAA
--
GREDEWLPIRPGTD
G
AL
AC
A
IAWVLITEN
M
VDQPFLDKYCVGYDEKTLPA
N
AP
R
N
A
HYKAYILGEG
T
D
S
I
AKTP
E
WAA
K
IT
S
IP
AE
K
II
Q
LAREIG
S
AKPAYICQGWGPQR
H
S
NGEQT
S
RAIAML
SV
LTGNVGI
N
GGNSG
-----------
V
REG
SWDLGV
E
W
F
P
M
L
E
NPVKTQIS
V
F
T
WTDAIDHG
TE
MTA
T
R
-----
DGVR
---------
GKEKLDVPIKF
L
W
C
YA
S
NTL
I
NQH
G
DIN
H
THE
V
LQD
D
SKCEMIV
G
I
D
H
FMTASAKY
C
DILLPDLM
PT
EQEDLI
SHES
AGNMGY
V
I
LA
QPATS
A
KFERKPIYW
M
LSEVAKRLGPDVYQ
T
FTEGR
S
Q
HE
W
I
K
Y
L
H
----
AK
TK
E
R
N
P
E
MP
D
Y
E
E
M
K
TT
GI
F
---
K
K
K
C
P
E
EHYVA
F
R
AFR
E
DP
Q
ANPLKTPSGKIEIYS
ER
LAKIA
-------
D
TWEL
K
KDE
I
I
H
PLP
A
Y
TPG
FDGWD
D
P
L
R
K
T
Y
PLQL
T
GFHYK
A
RTHS
S
YGNID
V
L
Q
Q
---
AC
P
QEVWINPIDAQ
A
RGI
RH
GD
T
VRVFN
N
N
GE
M
L
IA
AKVTPRILPGV
T
A
I
GQGAW
L
K
A
D
M
F
GD
R
V
DHGGS
I
N
I
LT
S
H
RPSP
-
LAKGNP
S
HSNLV
Q
IEK
fig|585397.9.peg.1771
Escherichia coli ED1a (5-797/798)
ISRR
S
L
M
K
T
SA
L
GSLALA
SSA
F
T
LPF
S
QM
VR
A
A
Q
APV
-
E-
-
-
EK
A
VW
S
S
C
T
VNCGSRC
L
LRLHVKD
DT
V
Y
WVE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRR
-----
R
M
NHP
----
DRL
K
YPMKRVGKRGEGKFERISWDEALDTI
SDN
L
R
RI
L
K
D
YGNEAV
H
VL
Y
G
T
G
VD
GGN
I
T
N
S
---
-
NV
-
PY
RLMN
SC
GG
F
L
SR
YGSYSTAQIS
A
AM
S
Y
MF
G
A
-----
NDGNSP
D
DI
A
N
T
KLVVMFGNNPAET
------
RMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIVIDPRY
N
DTAA
--
GREDEWLPIRPGTD
G
AL
AC
A
IAWVLITEN
M
VDQPFLDKYCVGYDEKTLPA
N
AP
R
N
A
HYKAYILGEG
T
D
S
I
AKTP
E
WAA
K
IT
S
IP
AE
K
II
Q
LAREIG
S
AKPAYICQGWGPQR
H
S
NGEQT
S
RAIAML
SV
LTGNVGI
N
GGNSG
-----------
V
REG
SWDLGV
E
W
F
P
M
L
E
NPVKTQIS
V
F
T
WTDAIDHG
TE
MTA
T
R
-----
DGVR
---------
GKEKLDVPIKF
L
W
C
YA
S
NTL
I
NQH
G
DIN
H
THE
V
LQD
D
SKCEMIV
G
I
D
H
FMTASAKY
C
DILLPDLM
PT
EQEDLI
SHES
AGNMGY
V
I
LA
QPATS
A
KFERKPIYW
M
LSEVAKRLGPDVYQ
T
FTEGR
S
Q
HE
W
I
K
Y
L
H
----
AK
TK
E
R
N
P
E
MP
D
Y
E
E
M
K
TT
GI
F
---
K
K
K
C
P
E
EHYVA
F
R
AFR
E
DP
Q
ANPLKTPSGKIEIYS
ER
LAKIA
-------
D
TWEL
K
KDE
I
I
H
PLP
A
Y
TPG
FDGWD
D
P
L
R
K
T
Y
PLQL
T
GFHYK
A
RTHS
S
YGNID
V
L
Q
Q
---
AC
P
QEVWINPIDAQ
A
RGI
RH
GD
T
VRVFN
N
N
GE
M
L
IA
AKVTPRILPGV
T
A
I
GQGAW
L
K
A
D
M
F
GD
R
V
DHGGS
I
N
I
LT
S
H
RPSP
-
LAKGNP
S
HSNLV
Q
IEK
fig|574521.7.peg.1709
Escherichia coli O127:H6 str. E2348/69 (5-797/798)
ISRR
S
L
M
K
T
SA
L
GSLALA
SSA
F
T
LPF
S
QM
VR
A
A
Q
APV
-
E-
-
-
EK
A
VW
S
S
C
T
VNCGSRC
L
LRLHVKD
DT
V
Y
WVE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRR
-----
R
M
NHP
----
DRL
K
YPMKRVGKRGEGKFERISWDEALDTI
SDN
L
R
RI
L
K
D
YGNEAV
H
VL
Y
G
T
G
VD
GGN
I
T
N
S
---
-
NV
-
PY
RLMN
SC
GG
F
L
SR
YGSYSTAQIS
A
AM
S
Y
MF
G
A
-----
NDGNSP
D
DI
A
N
T
KLVVMFGNNPAET
------
RMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIVIDPRY
N
DTAA
--
GREDEWLPIRPGTD
G
AL
AC
A
IAWVLITEN
M
VDQPFLDKYCVGYDEKTLPA
N
AP
R
N
A
HYKAYILGEG
T
D
S
I
AKTP
E
WAA
K
IT
S
IP
AE
K
II
Q
LAREIG
S
AKPAYICQGWGPQR
H
S
NGEQT
S
RAIAML
SV
LTGNVGI
N
GGNSG
-----------
V
REG
SWDLGV
E
W
F
P
M
L
E
NPVKTQIS
V
F
T
WTDAIDHG
TE
MTA
T
R
-----
DGVR
---------
GKEKLDVPIKF
L
W
C
YA
S
NTL
I
NQH
G
DIN
H
THE
V
LQD
D
SKCEMIV
G
I
D
H
FMTASAKY
C
DILLPDLM
PT
EQEDLI
SHES
AGNMGY
V
I
LA
QPATS
A
KFERKPIYW
M
LSEVAKRLGPDVYQ
T
FTEGR
S
Q
HE
W
I
K
Y
L
H
----
AK
TK
E
R
N
P
E
MP
D
Y
E
E
M
K
TT
GI
F
---
K
K
K
C
P
E
EHYVA
F
R
AFR
E
DP
Q
ANPLKTPSGKIEIYS
ER
LAKIA
-------
D
TWEL
K
KDE
I
I
H
PLP
A
Y
TPG
FDGWD
D
P
L
R
K
T
Y
PLQL
T
GFHYK
A
RTHS
S
YGNID
V
L
Q
Q
---
AC
P
QEVWINPIDAQ
A
RGI
RH
GD
T
VRVFN
N
N
GE
M
L
IA
AKVTPRILPGV
T
A
I
GQGAW
L
K
A
D
M
F
GD
R
V
DHGGS
I
N
I
LT
S
H
RPSP
-
LAKGNP
S
HSNLV
Q
IEK
fig|405955.13.peg.1671
Escherichia coli APEC O1 (5-797/798)
ISRR
S
L
M
K
T
SA
L
GSLALA
SSA
F
T
LPF
S
QM
VR
A
A
Q
APV
-
E-
-
-
EK
A
VW
S
S
C
T
VNCGSRC
L
LRLHVKD
DT
V
Y
WVE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRR
-----
R
M
NHP
----
DRL
K
YPMKRVGKRGEGKFERISWDEALDTI
SDN
L
R
RI
L
K
D
YGNEAV
H
VL
Y
G
T
G
VD
GGN
I
T
N
S
---
-
NV
-
PY
RLMN
SC
GG
F
L
SR
YGSYSTAQIS
A
AM
S
Y
MF
G
A
-----
NDGNSP
D
DI
A
N
T
KLVVMFGNNPAET
------
RMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIVIDPRY
N
DTAA
--
GREDEWLPIRPGTD
G
AL
AC
A
IAWVLITEN
M
VDQPFLDKYCVGYDEKTLPA
N
AP
R
N
A
HYKAYILGEG
P
D
G
I
AKTP
E
WAA
K
IT
S
IP
AE
K
II
Q
LAREIG
S
AKPAYICQGWGPQR
H
S
NGEQT
S
RAIAML
SV
LTGNVGI
N
GGNSG
-----------
V
REG
SWDLGV
E
W
F
P
M
L
E
NPVKTQIS
V
F
T
WTDAIDHG
TE
MTA
P
R
-----
DGVR
---------
GKEKLDVPIKF
L
W
C
YA
S
NTL
I
NQH
G
DIN
H
THE
V
LQD
D
SKCEMIV
G
I
D
H
FMTASAKY
C
DILLPDLM
PT
EQEDLI
SHES
AGNMGY
V
I
LA
QPATS
A
KFERKPIYW
M
LSEVAKRLGPDVYQ
T
FTEGR
S
Q
HE
W
I
K
Y
L
H
----
AK
TK
E
R
N
P
E
MP
D
Y
E
E
M
K
TT
GI
F
---
K
K
K
C
P
E
EHYVA
F
R
AFR
V
DP
Q
ANPLKTPSGKIEIYS
ER
LAKIA
-------
D
TWEL
K
KDE
I
I
H
PLP
A
Y
TPG
FDGWD
D
P
L
R
K
T
Y
PLQL
T
GFHYK
A
RTHS
S
YGNID
V
L
Q
Q
---
AC
P
QEVWINPIDAQ
A
RGI
RH
GD
T
VRVFN
N
N
GE
M
L
IA
AKVTPRILPGV
T
A
I
GQGAW
L
K
A
D
M
F
GD
R
V
DHGGS
I
N
I
LT
S
H
RPSP
-
LAKGNP
S
HSNLV
Q
IEK
fig|405955.9.peg.1356
Escherichia coli APEC O1 (15-807/808)
ISRR
S
L
M
K
T
SA
L
GSLALA
SSA
F
T
LPF
S
QM
VR
A
A
Q
APV
-
E-
-
-
EK
A
VW
S
S
C
T
VNCGSRC
L
LRLHVKD
DT
V
Y
WVE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRR
-----
R
M
NHP
----
DRL
K
YPMKRVGKRGEGKFERISWDEALDTI
SDN
L
R
RI
L
K
D
YGNEAV
H
VL
Y
G
T
G
VD
GGN
I
T
N
S
---
-
NV
-
PY
RLMN
SC
GG
F
L
SR
YGSYSTAQIS
A
AM
S
Y
MF
G
A
-----
NDGNSP
D
DI
A
N
T
KLVVMFGNNPAET
------
RMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIVIDPRY
N
DTAA
--
GREDEWLPIRPGTD
G
AL
AC
A
IAWVLITEN
M
VDQPFLDKYCVGYDEKTLPA
N
AP
R
N
A
HYKAYILGEG
P
D
G
I
AKTP
E
WAA
K
IT
S
IP
AE
K
II
Q
LAREIG
S
AKPAYICQGWGPQR
H
S
NGEQT
S
RAIAML
SV
LTGNVGI
N
GGNSG
-----------
V
REG
SWDLGV
E
W
F
P
M
L
E
NPVKTQIS
V
F
T
WTDAIDHG
TE
MTA
P
R
-----
DGVR
---------
GKEKLDVPIKF
L
W
C
YA
S
NTL
I
NQH
G
DIN
H
THE
V
LQD
D
SKCEMIV
G
I
D
H
FMTASAKY
C
DILLPDLM
PT
EQEDLI
SHES
AGNMGY
V
I
LA
QPATS
A
KFERKPIYW
M
LSEVAKRLGPDVYQ
T
FTEGR
S
Q
HE
W
I
K
Y
L
H
----
AK
TK
E
R
N
P
E
MP
D
Y
E
E
M
K
TT
GI
F
---
K
K
K
C
P
E
EHYVA
F
R
AFR
V
DP
Q
ANPLKTPSGKIEIYS
ER
LAKIA
-------
D
TWEL
K
KDE
I
I
H
PLP
A
Y
TPG
FDGWD
D
P
L
R
K
T
Y
PLQL
T
GFHYK
A
RTHS
S
YGNID
V
L
Q
Q
---
AC
P
QEVWINPIDAQ
A
RGI
RH
GD
T
VRVFN
N
N
GE
M
L
IA
AKVTPRILPGV
T
A
I
GQGAW
L
K
A
D
M
F
GD
R
V
DHGGS
I
N
I
LT
S
H
RPSP
-
LAKGNP
S
HSNLV
Q
IEK
fig|714962.3.peg.1739
Escherichia coli IHE3034 (5-797/798)
ISRR
S
L
M
K
T
SA
L
GSLALA
SSA
F
T
LPF
S
QM
VR
A
A
Q
APV
-
E-
-
-
EK
A
VW
S
S
C
T
VNCGSRC
L
LRLHVKD
DT
V
Y
WVE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRR
-----
R
M
NHP
----
DRL
K
YPMKRVGKRGEGKFERISWDEALDTI
SDN
L
R
RI
L
K
D
YGNEAV
H
VL
Y
G
T
G
VD
GGN
I
T
N
S
---
-
NV
-
PY
RLMN
SC
GG
F
L
SR
YGSYSTAQIS
A
AM
S
Y
MF
G
A
-----
NDGNSP
D
DI
A
N
T
KLVVMFGNNPAET
------
RMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIVIDPRY
N
DTAA
--
GREDEWLPIRPGTD
G
AL
AC
A
IAWVLITEN
M
VDQPFLDKYCVGYDEKTLPA
N
AP
R
N
A
HYKAYILGEG
P
D
G
I
AKTP
E
WAA
K
IT
S
IP
AE
K
II
Q
LAREIG
S
AKPAYICQGWGPQR
H
S
NGEQT
S
RAIAML
SV
LTGNVGI
N
GGNSG
-----------
V
REG
SWDLGV
E
W
F
P
M
L
E
NPVKTQIS
V
F
T
WTDAIDHG
TE
MTA
P
R
-----
DGVR
---------
GKEKLDVPIKF
L
W
C
YA
S
NTL
I
NQH
G
DIN
H
THE
V
LQD
D
SKCEMIV
G
I
D
H
FMTASAKY
C
DILLPDLM
PT
EQEDLI
SHES
AGNMGY
V
I
LA
QPATS
A
KFERKPIYW
M
LSEVAKRLGPDVYQ
T
FTEGR
S
Q
HE
W
I
K
Y
L
H
----
AK
TK
E
R
N
P
E
MP
D
Y
E
E
M
K
TT
GI
F
---
K
K
K
C
P
E
EHYVA
F
R
AFR
V
DP
Q
ANPLKTPSGKIEIYS
ER
LAKIA
-------
D
TWEL
K
KDE
I
I
H
PLP
A
Y
TPG
FDGWD
D
P
L
R
K
T
Y
PLQL
T
GFHYK
A
RTHS
S
YGNID
V
L
Q
Q
---
AC
P
QEVWINPIDAQ
A
RGI
RH
GD
T
VRVFN
N
N
GE
M
L
IA
AKVTPRILPGV
T
A
I
GQGAW
L
K
A
D
M
F
GD
R
V
DHGGS
I
N
I
LT
S
H
RPSP
-
LAKGNP
S
HSNLV
Q
IEK
fig|585035.6.peg.1626
Escherichia coli S88 (5-797/798)
ISRR
S
L
M
K
T
SA
L
GSLALA
SSA
F
T
LPF
S
QM
VR
A
A
Q
APV
-
E-
-
-
EK
A
VW
S
S
C
T
VNCGSRC
L
LRLHVKD
DT
V
Y
WVE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRR
-----
R
M
NHP
----
DRL
K
YPMKRVGKRGEGKFERISWDEALDTI
SDN
L
R
RI
L
K
D
YGNEAV
H
VL
Y
G
T
G
VD
GGN
I
T
N
S
---
-
NV
-
PY
RLMN
SC
GG
F
L
SR
YGSYSTAQIS
A
AM
S
Y
MF
G
A
-----
NDGNSP
D
DI
A
N
T
KLVVMFGNNPAET
------
RMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIVIDPRY
N
DTAA
--
GREDEWLPIRPGTD
G
AL
AC
A
IAWVLITEN
M
VDQPFLDKYCVGYDEKTLPA
N
AP
R
N
A
HYKAYILGEG
P
D
G
I
AKTP
E
WAA
K
IT
S
IP
AE
K
II
Q
LAREIG
S
AKPAYICQGWGPQR
H
S
NGEQT
S
RAIAML
SV
LTGNVGI
N
GGNSG
-----------
V
REG
SWDLGV
E
W
F
P
M
L
E
NPVKTQIS
V
F
T
WTDAIDHG
TE
MTA
P
R
-----
DGVR
---------
GKEKLDVPIKF
L
W
C
YA
S
NTL
I
NQH
G
DIN
H
THE
V
LQD
D
SKCEMIV
G
I
D
H
FMTASAKY
C
DILLPDLM
PT
EQEDLI
SHES
AGNMGY
V
I
LA
QPATS
A
KFERKPIYW
M
LSEVAKRLGPDVYQ
T
FTEGR
S
Q
HE
W
I
K
Y
L
H
----
AK
TK
E
R
N
P
E
MP
D
Y
E
E
M
K
TT
GI
F
---
K
K
K
C
P
E
EHYVA
F
R
AFR
V
DP
Q
ANPLKTPSGKIEIYS
ER
LAKIA
-------
D
TWEL
K
KDE
I
I
H
PLP
A
Y
TPG
FDGWD
D
P
L
R
K
T
Y
PLQL
T
GFHYK
A
RTHS
S
YGNID
V
L
Q
Q
---
AC
P
QEVWINPIDAQ
A
RGI
RH
GD
T
VRVFN
N
N
GE
M
L
IA
AKVTPRILPGV
T
A
I
GQGAW
L
K
A
D
M
F
GD
R
V
DHGGS
I
N
I
LT
S
H
RPSP
-
LAKGNP
S
HSNLV
Q
IEK
fig|869729.3.peg.1959
Escherichia coli UM146 (5-797/798)
ISRR
S
L
M
K
T
SA
L
GSLALA
SSA
F
T
LPF
S
QM
VR
A
A
Q
APV
-
E-
-
-
EK
A
VW
S
S
C
T
VNCGSRC
L
LRLHVKD
DT
V
Y
WVE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRR
-----
R
M
NHP
----
DRL
K
YPMKRVGKRGEGKFERISWDEALDTI
SDN
L
R
RI
L
K
D
YGNEAV
H
VL
Y
G
T
G
VD
GGN
I
T
N
S
---
-
NV
-
PY
RLMN
SC
GG
F
L
SR
YGSYSTAQIS
A
AM
S
Y
MF
G
A
-----
NDGNSP
D
DI
A
N
T
KLVVMFGNNPAET
------
RMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIVIDPRY
N
DTAA
--
GREDEWLPIRPGTD
G
AL
AC
A
IAWVLITEN
M
VDQPFLDKYCVGYDEKTLPA
N
AP
R
N
A
HYKAYILGEG
P
D
G
I
AKTP
E
WAA
K
IT
S
IP
AE
K
II
Q
LAREIG
S
AKPAYICQGWGPQR
H
S
NGEQT
S
RAIAML
SV
LTGNVGI
N
GGNSG
-----------
V
REG
SWDLGV
E
W
F
P
M
L
E
NPVKTQIS
V
F
T
WTDAIDHG
TE
MTA
P
R
-----
DGVR
---------
GKEKLDVPIKF
L
W
C
YA
S
NTL
I
NQH
G
DIN
H
THE
V
LQD
D
SKCEMIV
G
I
D
H
FMTASAKY
C
DILLPDLM
PT
EQEDLI
SHES
AGNMGY
V
I
LA
QPATS
A
KFERKPIYW
M
LSEVAKRLGPDVYQ
T
FTEGR
S
Q
HE
W
I
K
Y
L
H
----
AK
TK
E
R
N
P
E
MP
D
Y
E
E
M
K
TT
GI
F
---
K
K
K
C
P
E
EHYVA
F
R
AFR
V
DP
Q
ANPLKTPSGKIEIYS
ER
LAKIA
-------
D
TWEL
K
KDE
I
I
H
PLP
A
Y
TPG
FDGWD
D
P
L
R
K
T
Y
PLQL
T
GFHYK
A
RTHS
S
YGNID
V
L
Q
Q
---
AC
P
QEVWINPIDAQ
A
RGI
RH
GD
T
VRVFN
N
N
GE
M
L
IA
AKVTPRILPGV
T
A
I
GQGAW
L
K
A
D
M
F
GD
R
V
DHGGS
I
N
I
LT
S
H
RPSP
-
LAKGNP
S
HSNLV
Q
IEK
fig|364106.7.peg.1818
Escherichia coli UTI89 (5-797/798)
ISRR
S
L
M
K
T
SA
L
GSLALA
SSA
F
T
LPF
S
QM
VR
A
A
Q
APV
-
E-
-
-
EK
A
VW
S
S
C
T
VNCGSRC
L
LRLHVKD
DT
V
Y
WVE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRR
-----
R
M
NHP
----
DRL
K
YPMKRVGKRGEGKFERISWDEALDTI
SDN
L
R
RI
L
K
D
YGNEAV
H
VL
Y
G
T
G
VD
GGN
I
T
N
S
---
-
NV
-
PY
RLMN
SC
GG
F
L
SR
YGSYSTAQIS
A
AM
S
Y
MF
G
A
-----
NDGNSP
D
DI
A
N
T
KLVVMFGNNPAET
------
RMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIVIDPRY
N
DTAA
--
GREDEWLPIRPGTD
G
AL
AC
A
IAWVLITEN
M
VDQPFLDKYCVGYDEKTLPA
N
AP
R
N
A
HYKAYILGEG
P
D
G
I
AKTP
E
WAA
K
IT
S
IP
AE
K
II
Q
LAREIG
S
AKPAYICQGWGPQR
H
S
NGEQT
S
RAIAML
SV
LTGNVGI
N
GGNSG
-----------
V
REG
SWDLGV
E
W
F
P
M
L
E
NPVKTQIS
V
F
T
WTDAIDHG
TE
MTA
P
R
-----
DGVR
---------
GKEKLDVPIKF
L
W
C
YA
S
NTL
I
NQH
G
DIN
H
THE
V
LQD
D
SKCEMIV
G
I
D
H
FMTASAKY
C
DILLPDLM
PT
EQEDLI
SHES
AGNMGY
V
I
LA
QPATS
A
KFERKPIYW
M
LSEVAKRLGPDVYQ
T
FTEGR
S
Q
HE
W
I
K
Y
L
H
----
AK
TK
E
R
N
P
E
MP
D
Y
E
E
M
K
TT
GI
F
---
K
K
K
C
P
E
EHYVA
F
R
AFR
V
DP
Q
ANPLKTPSGKIEIYS
ER
LAKIA
-------
D
TWEL
K
KDE
I
I
H
PLP
A
Y
TPG
FDGWD
D
P
L
R
K
T
Y
PLQL
T
GFHYK
A
RTHS
S
YGNID
V
L
Q
Q
---
AC
P
QEVWINPIDAQ
A
RGI
RH
GD
T
VRVFN
N
N
GE
M
L
IA
AKVTPRILPGV
T
A
I
GQGAW
L
K
A
D
M
F
GD
R
V
DHGGS
I
N
I
LT
S
H
RPSP
-
LAKGNP
S
HSNLV
Q
IEK
fig|364106.8.peg.1821
Escherichia coli UTI89 (5-797/798)
ISRR
S
L
M
K
T
SA
L
GSLALA
SSA
F
T
LPF
S
QM
VR
A
A
Q
APV
-
E-
-
-
EK
A
VW
S
S
C
T
VNCGSRC
L
LRLHVKD
DT
V
Y
WVE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRR
-----
R
M
NHP
----
DRL
K
YPMKRVGKRGEGKFERISWDEALDTI
SDN
L
R
RI
L
K
D
YGNEAV
H
VL
Y
G
T
G
VD
GGN
I
T
N
S
---
-
NV
-
PY
RLMN
SC
GG
F
L
SR
YGSYSTAQIS
A
AM
S
Y
MF
G
A
-----
NDGNSP
D
DI
A
N
T
KLVVMFGNNPAET
------
RMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIVIDPRY
N
DTAA
--
GREDEWLPIRPGTD
G
AL
AC
A
IAWVLITEN
M
VDQPFLDKYCVGYDEKTLPA
N
AP
R
N
A
HYKAYILGEG
P
D
G
I
AKTP
E
WAA
K
IT
S
IP
AE
K
II
Q
LAREIG
S
AKPAYICQGWGPQR
H
S
NGEQT
S
RAIAML
SV
LTGNVGI
N
GGNSG
-----------
V
REG
SWDLGV
E
W
F
P
M
L
E
NPVKTQIS
V
F
T
WTDAIDHG
TE
MTA
P
R
-----
DGVR
---------
GKEKLDVPIKF
L
W
C
YA
S
NTL
I
NQH
G
DIN
H
THE
V
LQD
D
SKCEMIV
G
I
D
H
FMTASAKY
C
DILLPDLM
PT
EQEDLI
SHES
AGNMGY
V
I
LA
QPATS
A
KFERKPIYW
M
LSEVAKRLGPDVYQ
T
FTEGR
S
Q
HE
W
I
K
Y
L
H
----
AK
TK
E
R
N
P
E
MP
D
Y
E
E
M
K
TT
GI
F
---
K
K
K
C
P
E
EHYVA
F
R
AFR
V
DP
Q
ANPLKTPSGKIEIYS
ER
LAKIA
-------
D
TWEL
K
KDE
I
I
H
PLP
A
Y
TPG
FDGWD
D
P
L
R
K
T
Y
PLQL
T
GFHYK
A
RTHS
S
YGNID
V
L
Q
Q
---
AC
P
QEVWINPIDAQ
A
RGI
RH
GD
T
VRVFN
N
N
GE
M
L
IA
AKVTPRILPGV
T
A
I
GQGAW
L
K
A
D
M
F
GD
R
V
DHGGS
I
N
I
LT
S
H
RPSP
-
LAKGNP
S
HSNLV
Q
IEK
fig|656414.3.peg.1890
Escherichia coli H736 (15-807/808)
ISRR
S
L
M
K
T
SA
L
GSLALA
SSA
F
T
LPF
S
QM
VR
A
A
E
APV
-
E-
-
-
EK
A
VW
S
S
C
T
VNCGSRC
L
LRLHVKD
DT
V
Y
WVE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRR
-----
R
M
NHP
----
DRL
K
YPMKRVGKRGEGKFERISWDEALDTI
SDN
L
R
RI
L
K
D
YGNEAV
H
VL
Y
G
T
G
VD
GGN
I
T
N
S
---
-
NV
-
PY
RLMN
SC
GG
F
L
SR
YGSYSTAQIS
A
AM
S
Y
MF
G
A
-----
NDGNSP
D
DI
A
N
T
KLVVMFGNNPAET
------
RMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIVIDPRY
N
DTAA
--
GREDEWLPIRPGTD
G
AL
AC
A
IAWVLITEN
M
VDQPFLDKYCVGYDEKTLPA
N
AP
R
N
A
HYKAYILGEG
P
D
G
I
AKTP
E
WAA
K
IT
S
IP
AE
K
II
Q
LAREIG
S
AKPAYICQGWGPQR
H
S
NGEQT
S
RAIAML
SV
LTGNVGI
N
GGNSG
-----------
V
REG
SWDLGV
E
W
F
P
M
L
E
NPVKTQIS
V
F
T
WTDAIDHG
TK
MTA
T
R
-----
DGVR
---------
GKEKLDVPIKF
L
W
C
YA
S
NTL
I
NQH
G
DIN
H
THE
V
LQD
D
SKCEMIV
G
I
D
H
FMTASAKY
C
DILLPDLM
PT
EQEDLI
SHES
AGNMGY
V
I
LA
QPATS
A
KFERKPIYW
M
LSEVAKRLGPDVYQ
T
FTEGR
S
Q
HE
W
I
K
Y
L
H
----
AK
TK
E
R
N
P
E
MP
D
Y
E
E
M
K
TT
GI
F
---
K
K
K
C
P
E
EHYVA
F
R
AFR
E
DP
Q
ANPLKTPSGKIEIYS
ER
LAKIA
-------
D
TWEL
K
KDE
I
I
H
PLP
A
Y
TPG
FDGWD
D
P
L
R
K
T
Y
PLQL
T
GFHYK
A
RTHS
S
YGNID
V
L
Q
Q
---
AC
P
QEVWINPIDAQ
A
RGI
RH
GD
T
VRVFN
N
N
GE
M
L
IA
AKVTPRILPGV
T
A
I
GQGAW
L
K
A
D
M
F
GD
R
V
DHGGS
I
N
I
LT
S
H
RPSP
-
LAKGNP
S
HSNLV
Q
IEK
fig|656414.3.peg.1891
Escherichia coli H736 (5-797/798)
ISRR
S
L
M
K
T
SA
L
GSLALA
SSA
F
T
LPF
S
QM
VR
A
A
E
APV
-
E-
-
-
EK
A
VW
S
S
C
T
VNCGSRC
L
LRLHVKD
DT
V
Y
WVE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRR
-----
R
M
NHP
----
DRL
K
YPMKRVGKRGEGKFERISWDEALDTI
SDN
L
R
RI
L
K
D
YGNEAV
H
VL
Y
G
T
G
VD
GGN
I
T
N
S
---
-
NV
-
PY
RLMN
SC
GG
F
L
SR
YGSYSTAQIS
A
AM
S
Y
MF
G
A
-----
NDGNSP
D
DI
A
N
T
KLVVMFGNNPAET
------
RMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIVIDPRY
N
DTAA
--
GREDEWLPIRPGTD
G
AL
AC
A
IAWVLITEN
M
VDQPFLDKYCVGYDEKTLPA
N
AP
R
N
A
HYKAYILGEG
P
D
G
I
AKTP
E
WAA
K
IT
S
IP
AE
K
II
Q
LAREIG
S
AKPAYICQGWGPQR
H
S
NGEQT
S
RAIAML
SV
LTGNVGI
N
GGNSG
-----------
V
REG
SWDLGV
E
W
F
P
M
L
E
NPVKTQIS
V
F
T
WTDAIDHG
TK
MTA
T
R
-----
DGVR
---------
GKEKLDVPIKF
L
W
C
YA
S
NTL
I
NQH
G
DIN
H
THE
V
LQD
D
SKCEMIV
G
I
D
H
FMTASAKY
C
DILLPDLM
PT
EQEDLI
SHES
AGNMGY
V
I
LA
QPATS
A
KFERKPIYW
M
LSEVAKRLGPDVYQ
T
FTEGR
S
Q
HE
W
I
K
Y
L
H
----
AK
TK
E
R
N
P
E
MP
D
Y
E
E
M
K
TT
GI
F
---
K
K
K
C
P
E
EHYVA
F
R
AFR
E
DP
Q
ANPLKTPSGKIEIYS
ER
LAKIA
-------
D
TWEL
K
KDE
I
I
H
PLP
A
Y
TPG
FDGWD
D
P
L
R
K
T
Y
PLQL
T
GFHYK
A
RTHS
S
YGNID
V
L
Q
Q
---
AC
P
QEVWINPIDAQ
A
RGI
RH
GD
T
VRVFN
N
N
GE
M
L
IA
AKVTPRILPGV
T
A
I
GQGAW
L
K
A
D
M
F
GD
R
V
DHGGS
I
N
I
LT
S
H
RPSP
-
LAKGNP
S
HSNLV
Q
IEK
fig|1040638.4.peg.3634
Escherichia coli O104:H4 str. LB226692 (5-797/798)
ISRR
S
L
M
K
T
SA
L
GSLALA
SSA
F
T
LPF
S
QM
VR
A
A
E
APV
-
E-
-
-
EK
A
VW
S
S
C
T
VNCGSRC
L
LRLHVKD
DT
V
Y
WVE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRR
-----
R
M
NHP
----
DRL
K
YPMKRVGKRGEGKFERISWDEALDTI
SDN
L
R
RI
L
K
D
YGNEAV
H
VL
Y
G
T
G
VD
GGN
I
T
N
S
---
-
NV
-
PY
RLMN
SC
GG
F
L
SR
YGSYSTAQIS
A
AM
S
Y
MF
G
A
-----
NDGNSP
D
DI
A
N
T
KLVVMFGNNPAET
------
RMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIVIDPRY
N
DTAA
--
GREDEWLPIRPGTD
G
AL
AC
A
IAWVLITEN
M
VDQPFLDKYCVGYDEKTLPA
N
AP
R
N
A
HYKAYILGEG
P
D
G
I
AKTP
E
WAA
K
IT
S
IP
AE
K
II
Q
LAREIG
S
AKPAYICQGWGPQR
H
S
NGEQT
S
RAIAML
SV
LTGNVGI
N
GGNSG
-----------
V
REG
SWDLGV
E
W
F
P
M
L
E
NPVKTQIS
V
F
T
WTDAIDHG
KE
MTA
T
R
-----
DGVR
---------
GKEKLDVPIKF
L
W
C
YA
S
NTL
I
NQH
G
DIN
H
THE
V
LQD
D
SKCEMIV
G
I
D
H
FMTASAKY
C
DILLPDLM
PT
EQEDLI
SHES
AGNMGY
V
I
LA
QPATS
A
KFERKPIYW
M
LSEVAKRLGPDVYQ
T
FTEGR
S
Q
HE
W
I
K
Y
L
H
----
AK
TK
E
R
N
P
E
MP
D
Y
E
E
M
K
TT
GI
F
---
K
K
K
C
P
E
EHYVA
F
R
AFR
E
DP
Q
ANPLKTPSGKIEIYS
ER
LAKIA
-------
D
TWEL
K
KDE
I
I
H
PLP
A
Y
TPG
FDGWD
D
P
L
R
K
T
Y
PLQL
T
GFHYK
A
RTHS
S
YGNID
V
L
Q
Q
---
AC
P
QEVWINPIDAQ
A
RGI
RH
GD
T
VRVFN
N
N
GE
M
L
IA
AKVTPRILPGV
T
A
I
GQGAW
L
K
A
D
M
F
GD
R
V
DHGGS
I
N
I
LT
S
H
RPSP
-
LAKGNP
S
HSNLV
Q
IEK
fig|6666666.5357.peg.2359
Escherichia coli TY-2482 (15-807/808)
ISRR
S
L
M
K
T
SA
L
GSLALA
SSA
F
T
LPF
S
QM
VR
A
A
E
APV
-
E-
-
-
EK
A
VW
S
S
C
T
VNCGSRC
L
LRLHVKD
DT
V
Y
WVE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRR
-----
R
M
NHP
----
DRL
K
YPMKRVGKRGEGKFERISWDEALDTI
SDN
L
R
RI
L
K
D
YGNEAV
H
VL
Y
G
T
G
VD
GGN
I
T
N
S
---
-
NV
-
PY
RLMN
SC
GG
F
L
SR
YGSYSTAQIS
A
AM
S
Y
MF
G
A
-----
NDGNSP
D
DI
A
N
T
KLVVMFGNNPAET
------
RMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIVIDPRY
N
DTAA
--
GREDEWLPIRPGTD
G
AL
AC
A
IAWVLITEN
M
VDQPFLDKYCVGYDEKTLPA
N
AP
R
N
A
HYKAYILGEG
P
D
G
I
AKTP
E
WAA
K
IT
S
IP
AE
K
II
Q
LAREIG
S
AKPAYICQGWGPQR
H
S
NGEQT
S
RAIAML
SV
LTGNVGI
N
GGNSG
-----------
V
REG
SWDLGV
E
W
F
P
M
L
E
NPVKTQIS
V
F
T
WTDAIDHG
KE
MTA
T
R
-----
DGVR
---------
GKEKLDVPIKF
L
W
C
YA
S
NTL
I
NQH
G
DIN
H
THE
V
LQD
D
SKCEMIV
G
I
D
H
FMTASAKY
C
DILLPDLM
PT
EQEDLI
SHES
AGNMGY
V
I
LA
QPATS
A
KFERKPIYW
M
LSEVAKRLGPDVYQ
T
FTEGR
S
Q
HE
W
I
K
Y
L
H
----
AK
TK
E
R
N
P
E
MP
D
Y
E
E
M
K
TT
GI
F
---
K
K
K
C
P
E
EHYVA
F
R
AFR
E
DP
Q
ANPLKTPSGKIEIYS
ER
LAKIA
-------
D
TWEL
K
KDE
I
I
H
PLP
A
Y
TPG
FDGWD
D
P
L
R
K
T
Y
PLQL
T
GFHYK
A
RTHS
S
YGNID
V
L
Q
Q
---
AC
P
QEVWINPIDAQ
A
RGI
RH
GD
T
VRVFN
N
N
GE
M
L
IA
AKVTPRILPGV
T
A
I
GQGAW
L
K
A
D
M
F
GD
R
V
DHGGS
I
N
I
LT
S
H
RPSP
-
LAKGNP
S
HSNLV
Q
IEK
fig|358709.5.peg.1103
Escherichia coli 101-1 (5-797/798)
ISRR
S
L
M
K
T
SA
L
GSLALA
SSA
F
T
LPF
S
QM
VR
A
A
E
APV
-
E-
-
-
EK
A
VW
S
S
C
T
VNCGSRC
L
LRLHVKD
DT
V
Y
WVE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRR
-----
R
M
NHP
----
DRL
K
YPMKRVGKRGEGKFERISWDEALDTI
SDN
L
R
RI
L
K
D
YGNEAV
H
VL
Y
G
T
G
VD
GGN
I
T
N
S
---
-
NV
-
PY
RLMN
SC
GG
F
L
SR
YGSYSTAQIS
A
AM
S
Y
MF
G
A
-----
NDGNSP
D
DI
A
N
T
KLVVMFGNNPAET
------
RMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIVIDPRY
N
DTAA
--
GREDEWLPIRPGTD
G
AL
AC
A
IAWVLITEN
M
VDQPFLDKYCVGYDEKTLPA
N
AP
R
N
A
HYKAYILGEG
P
D
G
I
AKTP
E
WAA
K
IT
S
IP
AE
K
II
Q
LAREIG
S
AKPAYICQGWGPQR
H
S
NGEQT
S
RAIAML
SV
LTGNVGI
N
GGNSG
-----------
V
REG
SWDLGV
E
W
F
P
M
L
E
NPVKTQIS
V
F
T
WTDAIDHG
TE
MTA
T
R
-----
DGVR
---------
GKEKLDVPIKF
L
W
C
YA
S
NTL
I
NQH
G
DIN
H
THE
V
LQD
D
SKCEMIV
G
I
D
H
FMTASAKY
C
DILLPDLM
PT
EQEDLI
SHES
AGNMGY
V
I
LA
QPATS
A
KFERKPIYW
M
LSEVAKRLGPDVYQ
T
FTEGR
S
Q
HE
W
I
K
Y
L
H
----
AK
TK
E
R
N
P
E
MP
D
Y
E
E
M
K
TT
GI
F
---
K
K
K
C
P
E
EHYVA
F
R
AFR
E
DP
Q
ANPLKTPSGKIEIYS
ER
LAKIA
-------
D
TWEL
K
KDE
I
I
H
PLP
A
Y
TPG
FDGWD
D
P
L
R
K
T
Y
PLQL
T
GFHYK
A
RTHS
S
YGNID
V
L
Q
Q
---
AC
P
QEVWINPIDAQ
A
RGI
RH
GD
T
VRVFN
N
N
GE
M
L
IA
AKVTPRILPGV
T
A
I
GQGAW
L
K
A
D
M
F
GD
R
V
DHGGS
I
N
I
LT
S
H
RPSP
-
LAKGNP
S
HSNLV
Q
IEK
fig|585055.6.peg.1783
Escherichia coli 55989 (5-797/798)
ISRR
S
L
M
K
T
SA
L
GSLALA
SSA
F
T
LPF
S
QM
VR
A
A
E
APV
-
E-
-
-
EK
A
VW
S
S
C
T
VNCGSRC
L
LRLHVKD
DT
V
Y
WVE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRR
-----
R
M
NHP
----
DRL
K
YPMKRVGKRGEGKFERISWDEALDTI
SDN
L
R
RI
L
K
D
YGNEAV
H
VL
Y
G
T
G
VD
GGN
I
T
N
S
---
-
NV
-
PY
RLMN
SC
GG
F
L
SR
YGSYSTAQIS
A
AM
S
Y
MF
G
A
-----
NDGNSP
D
DI
A
N
T
KLVVMFGNNPAET
------
RMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIVIDPRY
N
DTAA
--
GREDEWLPIRPGTD
G
AL
AC
A
IAWVLITEN
M
VDQPFLDKYCVGYDEKTLPA
N
AP
R
N
A
HYKAYILGEG
P
D
G
I
AKTP
E
WAA
K
IT
S
IP
AE
K
II
Q
LAREIG
S
AKPAYICQGWGPQR
H
S
NGEQT
S
RAIAML
SV
LTGNVGI
N
GGNSG
-----------
V
REG
SWDLGV
E
W
F
P
M
L
E
NPVKTQIS
V
F
T
WTDAIDHG
KE
MTA
T
R
-----
DGVR
---------
GKEKLDVPIKF
L
W
C
YA
S
NTL
I
NQH
G
DIN
H
THE
V
LQD
D
SKCEMIV
G
I
D
H
FMTASAKY
C
DILLPDLM
PT
EQEDLI
SHES
AGNMGY
V
I
LA
QPATS
A
KFERKPIYW
M
LSEVAKRLGPDVYQ
T
FTEGR
S
Q
HE
W
I
K
Y
L
H
----
AK
TK
E
R
N
P
E
MP
D
Y
E
E
M
K
TT
GI
F
---
K
K
K
C
P
E
EHYVA
F
R
AFR
E
DP
Q
ANPLKTPSGKIEIYS
ER
LAKIA
-------
D
TWEL
K
KDE
I
I
H
PLP
A
Y
TPG
FDGWD
D
P
L
R
K
T
Y
PLQL
T
GFHYK
A
RTHS
S
YGNID
V
L
Q
Q
---
AC
P
QEVWINPIDAQ
A
RGI
RH
GD
T
VRVFN
N
N
GE
M
L
IA
AKVTPRILPGV
T
A
I
GQGAW
L
K
A
D
M
F
GD
R
V
DHGGS
I
N
I
LT
S
H
RPSP
-
LAKGNP
S
HSNLV
Q
IEK
fig|585055.8.peg.1787
Escherichia coli 55989 (5-797/798)
ISRR
S
L
M
K
T
SA
L
GSLALA
SSA
F
T
LPF
S
QM
VR
A
A
E
APV
-
E-
-
-
EK
A
VW
S
S
C
T
VNCGSRC
L
LRLHVKD
DT
V
Y
WVE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRR
-----
R
M
NHP
----
DRL
K
YPMKRVGKRGEGKFERISWDEALDTI
SDN
L
R
RI
L
K
D
YGNEAV
H
VL
Y
G
T
G
VD
GGN
I
T
N
S
---
-
NV
-
PY
RLMN
SC
GG
F
L
SR
YGSYSTAQIS
A
AM
S
Y
MF
G
A
-----
NDGNSP
D
DI
A
N
T
KLVVMFGNNPAET
------
RMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIVIDPRY
N
DTAA
--
GREDEWLPIRPGTD
G
AL
AC
A
IAWVLITEN
M
VDQPFLDKYCVGYDEKTLPA
N
AP
R
N
A
HYKAYILGEG
P
D
G
I
AKTP
E
WAA
K
IT
S
IP
AE
K
II
Q
LAREIG
S
AKPAYICQGWGPQR
H
S
NGEQT
S
RAIAML
SV
LTGNVGI
N
GGNSG
-----------
V
REG
SWDLGV
E
W
F
P
M
L
E
NPVKTQIS
V
F
T
WTDAIDHG
KE
MTA
T
R
-----
DGVR
---------
GKEKLDVPIKF
L
W
C
YA
S
NTL
I
NQH
G
DIN
H
THE
V
LQD
D
SKCEMIV
G
I
D
H
FMTASAKY
C
DILLPDLM
PT
EQEDLI
SHES
AGNMGY
V
I
LA
QPATS
A
KFERKPIYW
M
LSEVAKRLGPDVYQ
T
FTEGR
S
Q
HE
W
I
K
Y
L
H
----
AK
TK
E
R
N
P
E
MP
D
Y
E
E
M
K
TT
GI
F
---
K
K
K
C
P
E
EHYVA
F
R
AFR
E
DP
Q
ANPLKTPSGKIEIYS
ER
LAKIA
-------
D
TWEL
K
KDE
I
I
H
PLP
A
Y
TPG
FDGWD
D
P
L
R
K
T
Y
PLQL
T
GFHYK
A
RTHS
S
YGNID
V
L
Q
Q
---
AC
P
QEVWINPIDAQ
A
RGI
RH
GD
T
VRVFN
N
N
GE
M
L
IA
AKVTPRILPGV
T
A
I
GQGAW
L
K
A
D
M
F
GD
R
V
DHGGS
I
N
I
LT
S
H
RPSP
-
LAKGNP
S
HSNLV
Q
IEK
fig|481805.3.peg.2200
Escherichia coli ATCC 8739 (15-807/808)
ISRR
S
L
M
K
T
SA
L
GSLALA
SSA
F
T
LPF
S
QM
VR
A
A
E
APV
-
E-
-
-
EK
A
VW
S
S
C
T
VNCGSRC
L
LRLHVKD
DT
V
Y
WVE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRR
-----
R
M
NHP
----
DRL
K
YPMKRVGKRGEGKFERISWDEALDTI
SDN
L
R
RI
L
K
D
YGNEAV
H
VL
Y
G
T
G
VD
GGN
I
T
N
S
---
-
NV
-
PY
RLMN
SC
GG
F
L
SR
YGSYSTAQIS
A
AM
S
Y
MF
G
A
-----
NDGNSP
D
DI
A
N
T
KLVVMFGNNPAET
------
RMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIVIDPRY
N
DTAA
--
GREDEWLPIRPGTD
G
AL
AC
A
IAWVLITEN
M
VDQPFLDKYCVGYDEKTLPA
N
AP
R
N
A
HYKAYILGEG
P
D
G
I
AKTP
E
WAA
K
IT
S
IP
AE
K
II
Q
LAREIG
S
AKPAYICQGWGPQR
H
S
NGEQT
S
RAIAML
SV
LTGNVGI
N
GGNSG
-----------
V
REG
SWDLGV
E
W
F
P
M
L
E
NPVKTQIS
V
F
T
WTDAIDHG
TE
MTA
T
R
-----
DGVR
---------
GKEKLDVPIKF
L
W
C
YA
S
NTL
I
NQH
G
DIN
H
THE
V
LQD
D
SKCEMIV
G
I
D
H
FMTASAKY
C
DILLPDLM
PT
EQEDLI
SHES
AGNMGY
V
I
LA
QPATS
A
KFERKPIYW
M
LSEVAKRLGPDVYQ
T
FTEGR
S
Q
HE
W
I
K
Y
L
H
----
AK
TK
E
R
N
P
E
MP
D
Y
E
E
M
K
TT
GI
F
---
K
K
K
C
P
E
EHYVA
F
R
AFR
E
DP
Q
ANPLKTPSGKIEIYS
ER
LAKIA
-------
D
TWEL
K
KDE
I
I
H
PLP
A
Y
TPG
FDGWD
D
P
L
R
K
T
Y
PLQL
T
GFHYK
A
RTHS
S
YGNID
V
L
Q
Q
---
AC
P
QEVWINPIDAQ
A
RGI
RH
GD
T
VRVFN
N
N
GE
M
L
IA
AKVTPRILPGV
T
A
I
GQGAW
L
K
A
D
M
F
GD
R
V
DHGGS
I
N
I
LT
S
H
RPSP
-
LAKGNP
S
HSNLV
Q
IEK
fig|481805.6.peg.2193
Escherichia coli ATCC 8739 (5-797/798)
ISRR
S
L
M
K
T
SA
L
GSLALA
SSA
F
T
LPF
S
QM
VR
A
A
E
APV
-
E-
-
-
EK
A
VW
S
S
C
T
VNCGSRC
L
LRLHVKD
DT
V
Y
WVE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRR
-----
R
M
NHP
----
DRL
K
YPMKRVGKRGEGKFERISWDEALDTI
SDN
L
R
RI
L
K
D
YGNEAV
H
VL
Y
G
T
G
VD
GGN
I
T
N
S
---
-
NV
-
PY
RLMN
SC
GG
F
L
SR
YGSYSTAQIS
A
AM
S
Y
MF
G
A
-----
NDGNSP
D
DI
A
N
T
KLVVMFGNNPAET
------
RMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIVIDPRY
N
DTAA
--
GREDEWLPIRPGTD
G
AL
AC
A
IAWVLITEN
M
VDQPFLDKYCVGYDEKTLPA
N
AP
R
N
A
HYKAYILGEG
P
D
G
I
AKTP
E
WAA
K
IT
S
IP
AE
K
II
Q
LAREIG
S
AKPAYICQGWGPQR
H
S
NGEQT
S
RAIAML
SV
LTGNVGI
N
GGNSG
-----------
V
REG
SWDLGV
E
W
F
P
M
L
E
NPVKTQIS
V
F
T
WTDAIDHG
TE
MTA
T
R
-----
DGVR
---------
GKEKLDVPIKF
L
W
C
YA
S
NTL
I
NQH
G
DIN
H
THE
V
LQD
D
SKCEMIV
G
I
D
H
FMTASAKY
C
DILLPDLM
PT
EQEDLI
SHES
AGNMGY
V
I
LA
QPATS
A
KFERKPIYW
M
LSEVAKRLGPDVYQ
T
FTEGR
S
Q
HE
W
I
K
Y
L
H
----
AK
TK
E
R
N
P
E
MP
D
Y
E
E
M
K
TT
GI
F
---
K
K
K
C
P
E
EHYVA
F
R
AFR
E
DP
Q
ANPLKTPSGKIEIYS
ER
LAKIA
-------
D
TWEL
K
KDE
I
I
H
PLP
A
Y
TPG
FDGWD
D
P
L
R
K
T
Y
PLQL
T
GFHYK
A
RTHS
S
YGNID
V
L
Q
Q
---
AC
P
QEVWINPIDAQ
A
RGI
RH
GD
T
VRVFN
N
N
GE
M
L
IA
AKVTPRILPGV
T
A
I
GQGAW
L
K
A
D
M
F
GD
R
V
DHGGS
I
N
I
LT
S
H
RPSP
-
LAKGNP
S
HSNLV
Q
IEK
fig|413997.3.peg.1632
Escherichia coli B str. REL606 (5-797/798)
ISRR
S
L
M
K
T
SA
L
GSLALA
SSA
F
T
LPF
S
QM
VR
A
A
E
APV
-
E-
-
-
EK
A
VW
S
S
C
T
VNCGSRC
L
LRLHVKD
DT
V
Y
WVE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRR
-----
R
M
NHP
----
DRL
K
YPMKRVGKRGEGKFERISWDEALDTI
SDN
L
R
RI
L
K
D
YGNEAV
H
VL
Y
G
T
G
VD
GGN
I
T
N
S
---
-
NV
-
PY
RLMN
SC
GG
F
L
SR
YGSYSTAQIS
A
AM
S
Y
MF
G
A
-----
NDGNSP
D
DI
A
N
T
KLVVMFGNNPAET
------
RMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIVIDPRY
N
DTAA
--
GREDEWLPIRPGTD
G
AL
AC
A
IAWVLITEN
M
VDQPFLDKYCVGYDEKTLPA
N
AP
R
N
A
HYKAYILGEG
P
D
G
I
AKTP
E
WAA
K
IT
S
IP
AE
K
II
Q
LAREIG
S
AKPAYICQGWGPQR
H
S
NGEQT
S
RAIAML
SV
LTGNVGI
N
GGNSG
-----------
V
REG
SWDLGV
E
W
F
P
M
L
E
NPVKTQIS
V
F
T
WTDAIDHG
TE
MTA
T
R
-----
DGVR
---------
GKEKLDVPIKF
L
W
C
YA
S
NTL
I
NQH
G
DIN
H
THE
V
LQD
D
SKCEMIV
G
I
D
H
FMTASAKY
C
DILLPDLM
PT
EQEDLI
SHES
AGNMGY
V
I
LA
QPATS
A
KFERKPIYW
M
LSEVAKRLGPDVYQ
T
FTEGR
S
Q
HE
W
I
K
Y
L
H
----
AK
TK
E
R
N
P
E
MP
D
Y
E
E
M
K
TT
GI
F
---
K
K
K
C
P
E
EHYVA
F
R
AFR
E
DP
Q
ANPLKTPSGKIEIYS
ER
LAKIA
-------
D
TWEL
K
KDE
I
I
H
PLP
A
Y
TPG
FDGWD
D
P
L
R
K
T
Y
PLQL
T
GFHYK
A
RTHS
S
YGNID
V
L
Q
Q
---
AC
P
QEVWINPIDAQ
A
RGI
RH
GD
T
VRVFN
N
N
GE
M
L
IA
AKVTPRILPGV
T
A
I
GQGAW
L
K
A
D
M
F
GD
R
V
DHGGS
I
N
I
LT
S
H
RPSP
-
LAKGNP
S
HSNLV
Q
IEK
fig|550672.3.peg.2428
Escherichia coli B088 (15-807/808)
ISRR
S
L
M
K
T
SA
L
GSLALA
SSA
F
T
LPF
S
QM
VR
A
A
E
APV
-
E-
-
-
EK
A
VW
S
S
C
T
VNCGSRC
L
LRLHVKD
DT
V
Y
WVE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRR
-----
R
M
NHP
----
DRL
K
YPMKRVGKRGEGKFERISWDEALDTI
SDN
L
R
RI
L
K
D
YGNEAV
H
VL
Y
G
T
G
VD
GGN
I
T
N
S
---
-
NV
-
PY
RLMN
SC
GG
F
L
SR
YGSYSTAQIS
A
AM
S
Y
MF
G
A
-----
NDGNSP
D
DI
A
N
T
KLVVMFGNNPAET
------
RMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIVIDPRY
N
DTAA
--
GREDEWLPIRPGTD
G
AL
AC
A
IAWVLITEN
M
VDQPFLDKYCVGYDEKTLPA
N
AP
R
N
A
HYKAYILGEG
P
D
G
I
AKTP
E
WAA
K
IT
S
IP
AE
K
II
Q
LAREIG
S
AKPAYICQGWGPQR
H
S
NGEQT
S
RAIAML
SV
LTGNVGI
N
GGNSG
-----------
V
REG
SWDLGV
E
W
F
P
M
L
E
NPVKTQIS
V
F
T
WTDAIDHG
TE
MTA
T
R
-----
DGVR
---------
GKEKLDVPIKF
L
W
C
YA
S
NTL
I
NQH
G
DIN
H
THE
V
LQD
D
SKCEMIV
G
I
D
H
FMTASAKY
C
DILLPDLM
PT
EQEDLI
SHES
AGNMGY
V
I
LA
QPATS
A
KFERKPIYW
M
LSEVAKRLGPDVYQ
T
FTEGR
S
Q
HE
W
I
K
Y
L
H
----
AK
TK
E
R
N
P
E
MP
D
Y
E
E
M
K
TT
GI
F
---
K
K
K
C
P
E
EHYVA
F
R
AFR
E
DP
Q
ANPLKTPSGKIEIYS
ER
LAKIA
-------
D
TWEL
K
KDE
I
I
H
PLP
A
Y
TPG
FDGWD
D
P
L
R
K
T
Y
PLQL
T
GFHYK
A
RTHS
S
YGNID
V
L
Q
Q
---
AC
P
QEVWINPIDAQ
A
RGI
RH
GD
T
VRVFN
N
N
GE
M
L
IA
AKVTPRILPGV
T
A
I
GQGAW
L
K
A
D
M
F
GD
R
V
DHGGS
I
N
I
LT
S
H
RPSP
-
LAKGNP
S
HSNLV
Q
IEK
fig|344601.3.peg.332
Escherichia coli B171 (15-807/808)
ISRR
S
L
M
K
T
SA
L
GSLALA
SSA
F
T
LPF
S
QM
VR
A
A
E
APV
-
E-
-
-
EK
A
VW
S
S
C
T
VNCGSRC
L
LRLHVKD
DT
V
Y
WVE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRR
-----
R
M
NHP
----
DRL
K
YPMKRVGKRGEGKFERISWDEALDTI
SDN
L
R
RI
L
K
D
YGNEAV
H
VL
Y
G
T
G
VD
GGN
I
T
N
S
---
-
NV
-
PY
RLMN
SC
GG
F
L
SR
YGSYSTAQIS
A
AM
S
Y
MF
G
A
-----
NDGNSP
D
DI
A
N
T
KLVVMFGNNPAET
------
RMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIVIDPRY
N
DTAA
--
GREDEWLPIRPGTD
G
AL
AC
A
IAWVLITEN
M
VDQPFLDKYCVGYDEKTLPA
N
AP
R
N
A
HYKAYILGEG
P
D
G
I
AKTP
E
WAA
K
IT
S
IP
AE
K
II
Q
LAREIG
S
AKPAYICQGWGPQR
H
S
NGEQT
S
RAIAML
SV
LTGNVGI
N
GGNSG
-----------
V
REG
SWDLGV
E
W
F
P
M
L
E
NPVKTQIS
V
F
T
WTDAIDHG
KE
MTA
T
R
-----
DGVR
---------
GKEKLDVPIKF
L
W
C
YA
S
NTL
I
NQH
G
DIN
H
THE
V
LQD
D
SKCEMIV
G
I
D
H
FMTASAKY
C
DILLPDLM
PT
EQEDLI
SHES
AGNMGY
V
I
LA
QPATS
A
KFERKPIYW
M
LSEVAKRLGPDVYQ
T
FTEGR
S
Q
HE
W
I
K
Y
L
H
----
AK
TK
E
R
N
P
E
MP
D
Y
E
E
M
K
TT
GI
F
---
K
K
K
C
P
E
EHYVA
F
R
AFR
E
DP
Q
ANPLKTPSGKIEIYS
ER
LAKIA
-------
D
TWEL
K
KDE
I
I
H
PLP
A
Y
TPG
FDGWD
D
P
L
R
K
T
Y
PLQL
T
GFHYK
A
RTHS
S
YGNID
V
L
Q
Q
---
AC
P
QEVWINPIDAQ
A
RGI
RH
GD
T
VRVFN
N
N
GE
M
L
IA
AKVTPRILPGV
T
A
I
GQGAW
L
K
A
D
M
F
GD
R
V
DHGGS
I
N
I
LT
S
H
RPSP
-
LAKGNP
S
HSNLV
Q
IEK
fig|344601.5.peg.330
Escherichia coli B171 (5-797/798)
ISRR
S
L
M
K
T
SA
L
GSLALA
SSA
F
T
LPF
S
QM
VR
A
A
E
APV
-
E-
-
-
EK
A
VW
S
S
C
T
VNCGSRC
L
LRLHVKD
DT
V
Y
WVE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRR
-----
R
M
NHP
----
DRL
K
YPMKRVGKRGEGKFERISWDEALDTI
SDN
L
R
RI
L
K
D
YGNEAV
H
VL
Y
G
T
G
VD
GGN
I
T
N
S
---
-
NV
-
PY
RLMN
SC
GG
F
L
SR
YGSYSTAQIS
A
AM
S
Y
MF
G
A
-----
NDGNSP
D
DI
A
N
T
KLVVMFGNNPAET
------
RMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIVIDPRY
N
DTAA
--
GREDEWLPIRPGTD
G
AL
AC
A
IAWVLITEN
M
VDQPFLDKYCVGYDEKTLPA
N
AP
R
N
A
HYKAYILGEG
P
D
G
I
AKTP
E
WAA
K
IT
S
IP
AE
K
II
Q
LAREIG
S
AKPAYICQGWGPQR
H
S
NGEQT
S
RAIAML
SV
LTGNVGI
N
GGNSG
-----------
V
REG
SWDLGV
E
W
F
P
M
L
E
NPVKTQIS
V
F
T
WTDAIDHG
KE
MTA
T
R
-----
DGVR
---------
GKEKLDVPIKF
L
W
C
YA
S
NTL
I
NQH
G
DIN
H
THE
V
LQD
D
SKCEMIV
G
I
D
H
FMTASAKY
C
DILLPDLM
PT
EQEDLI
SHES
AGNMGY
V
I
LA
QPATS
A
KFERKPIYW
M
LSEVAKRLGPDVYQ
T
FTEGR
S
Q
HE
W
I
K
Y
L
H
----
AK
TK
E
R
N
P
E
MP
D
Y
E
E
M
K
TT
GI
F
---
K
K
K
C
P
E
EHYVA
F
R
AFR
E
DP
Q
ANPLKTPSGKIEIYS
ER
LAKIA
-------
D
TWEL
K
KDE
I
I
H
PLP
A
Y
TPG
FDGWD
D
P
L
R
K
T
Y
PLQL
T
GFHYK
A
RTHS
S
YGNID
V
L
Q
Q
---
AC
P
QEVWINPIDAQ
A
RGI
RH
GD
T
VRVFN
N
N
GE
M
L
IA
AKVTPRILPGV
T
A
I
GQGAW
L
K
A
D
M
F
GD
R
V
DHGGS
I
N
I
LT
S
H
RPSP
-
LAKGNP
S
HSNLV
Q
IEK
fig|550676.3.peg.1892
Escherichia coli B185 (5-797/798)
ISRR
S
L
M
K
T
SA
L
GSLALA
SSA
F
T
LPF
S
QM
VR
A
A
E
APV
-
E-
-
-
EK
A
VW
S
S
C
T
VNCGSRC
L
LRLHVKD
DT
V
Y
WVE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRR
-----
R
M
NHP
----
DRL
K
YPMKRVGKRGEGKFERISWDEALDTI
SDN
L
R
RI
L
K
D
YGNEAV
H
VL
Y
G
T
G
VD
GGN
I
T
N
S
---
-
NV
-
PY
RLMN
SC
GG
F
L
SR
YGSYSTAQIS
A
AM
S
Y
MF
G
A
-----
NDGNSP
D
DI
A
N
T
KLVVMFGNNPAET
------
RMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIVIDPRY
N
DTAA
--
GREDEWLPIRPGTD
G
AL
AC
A
IAWVLITEN
M
VDQPFLDKYCVGYDEKTLPA
N
AP
R
N
A
HYKAYILGEG
P
D
G
I
AKTP
E
WAA
K
IT
S
IP
AE
K
II
Q
LAREIG
S
AKPAYICQGWGPQR
H
S
NGEQT
S
RAIAML
SV
LTGNVGI
N
GGNSG
-----------
V
REG
SWDLGV
E
W
F
P
M
L
E
NPVKTQIS
V
F
T
WTDAIDHG
TE
MTA
T
R
-----
DGVR
---------
GKEKLDVPIKF
L
W
C
YA
S
NTL
I
NQH
G
DIN
H
THE
V
LQD
D
SKCEMIV
G
I
D
H
FMTASAKY
C
DILLPDLM
PT
EQEDLI
SHES
AGNMGY
V
I
LA
QPATS
A
KFERKPIYW
M
LSEVAKRLGPDVYQ
T
FTEGR
S
Q
HE
W
I
K
Y
L
H
----
AK
TK
E
R
N
P
E
MP
D
Y
E
E
M
K
TT
GI
F
---
K
K
K
C
P
E
EHYVA
F
R
AFR
E
DP
Q
ANPLKTPSGKIEIYS
ER
LAKIA
-------
D
TWEL
K
KDE
I
I
H
PLP
A
Y
TPG
FDGWD
D
P
L
R
K
T
Y
PLQL
T
GFHYK
A
RTHS
S
YGNID
V
L
Q
Q
---
AC
P
QEVWINPIDAQ
A
RGI
RH
GD
T
VRVFN
N
N
GE
M
L
IA
AKVTPRILPGV
T
A
I
GQGAW
L
K
A
D
M
F
GD
R
V
DHGGS
I
N
I
LT
S
H
RPSP
-
LAKGNP
S
HSNLV
Q
IEK
fig|511693.5.peg.1657
Escherichia coli BL21 (5-797/798)
ISRR
S
L
M
K
T
SA
L
GSLALA
SSA
F
T
LPF
S
QM
VR
A
A
E
APV
-
E-
-
-
EK
A
VW
S
S
C
T
VNCGSRC
L
LRLHVKD
DT
V
Y
WVE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRR
-----
R
M
NHP
----
DRL
K
YPMKRVGKRGEGKFERISWDEALDTI
SDN
L
R
RI
L
K
D
YGNEAV
H
VL
Y
G
T
G
VD
GGN
I
T
N
S
---
-
NV
-
PY
RLMN
SC
GG
F
L
SR
YGSYSTAQIS
A
AM
S
Y
MF
G
A
-----
NDGNSP
D
DI
A
N
T
KLVVMFGNNPAET
------
RMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIVIDPRY
N
DTAA
--
GREDEWLPIRPGTD
G
AL
AC
A
IAWVLITEN
M
VDQPFLDKYCVGYDEKTLPA
N
AP
R
N
A
HYKAYILGEG
P
D
G
I
AKTP
E
WAA
K
IT
S
IP
AE
K
II
Q
LAREIG
S
AKPAYICQGWGPQR
H
S
NGEQT
S
RAIAML
SV
LTGNVGI
N
GGNSG
-----------
V
REG
SWDLGV
E
W
F
P
M
L
E
NPVKTQIS
V
F
T
WTDAIDHG
TE
MTA
T
R
-----
DGVR
---------
GKEKLDVPIKF
L
W
C
YA
S
NTL
I
NQH
G
DIN
H
THE
V
LQD
D
SKCEMIV
G
I
D
H
FMTASAKY
C
DILLPDLM
PT
EQEDLI
SHES
AGNMGY
V
I
LA
QPATS
A
KFERKPIYW
M
LSEVAKRLGPDVYQ
T
FTEGR
S
Q
HE
W
I
K
Y
L
H
----
AK
TK
E
R
N
P
E
MP
D
Y
E
E
M
K
TT
GI
F
---
K
K
K
C
P
E
EHYVA
F
R
AFR
E
DP
Q
ANPLKTPSGKIEIYS
ER
LAKIA
-------
D
TWEL
K
KDE
I
I
H
PLP
A
Y
TPG
FDGWD
D
P
L
R
K
T
Y
PLQL
T
GFHYK
A
RTHS
S
YGNID
V
L
Q
Q
---
AC
P
QEVWINPIDAQ
A
RGI
RH
GD
T
VRVFN
N
N
GE
M
L
IA
AKVTPRILPGV
T
A
I
GQGAW
L
K
A
D
M
F
GD
R
V
DHGGS
I
N
I
LT
S
H
RPSP
-
LAKGNP
S
HSNLV
Q
IEK
fig|469008.4.peg.2117
Escherichia coli BL21(DE3) (5-797/798)
ISRR
S
L
M
K
T
SA
L
GSLALA
SSA
F
T
LPF
S
QM
VR
A
A
E
APV
-
E-
-
-
EK
A
VW
S
S
C
T
VNCGSRC
L
LRLHVKD
DT
V
Y
WVE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRR
-----
R
M
NHP
----
DRL
K
YPMKRVGKRGEGKFERISWDEALDTI
SDN
L
R
RI
L
K
D
YGNEAV
H
VL
Y
G
T
G
VD
GGN
I
T
N
S
---
-
NV
-
PY
RLMN
SC
GG
F
L
SR
YGSYSTAQIS
A
AM
S
Y
MF
G
A
-----
NDGNSP
D
DI
A
N
T
KLVVMFGNNPAET
------
RMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIVIDPRY
N
DTAA
--
GREDEWLPIRPGTD
G
AL
AC
A
IAWVLITEN
M
VDQPFLDKYCVGYDEKTLPA
N
AP
R
N
A
HYKAYILGEG
P
D
G
I
AKTP
E
WAA
K
IT
S
IP
AE
K
II
Q
LAREIG
S
AKPAYICQGWGPQR
H
S
NGEQT
S
RAIAML
SV
LTGNVGI
N
GGNSG
-----------
V
REG
SWDLGV
E
W
F
P
M
L
E
NPVKTQIS
V
F
T
WTDAIDHG
TE
MTA
T
R
-----
DGVR
---------
GKEKLDVPIKF
L
W
C
YA
S
NTL
I
NQH
G
DIN
H
THE
V
LQD
D
SKCEMIV
G
I
D
H
FMTASAKY
C
DILLPDLM
PT
EQEDLI
SHES
AGNMGY
V
I
LA
QPATS
A
KFERKPIYW
M
LSEVAKRLGPDVYQ
T
FTEGR
S
Q
HE
W
I
K
Y
L
H
----
AK
TK
E
R
N
P
E
MP
D
Y
E
E
M
K
TT
GI
F
---
K
K
K
C
P
E
EHYVA
F
R
AFR
E
DP
Q
ANPLKTPSGKIEIYS
ER
LAKIA
-------
D
TWEL
K
KDE
I
I
H
PLP
A
Y
TPG
FDGWD
D
P
L
R
K
T
Y
PLQL
T
GFHYK
A
RTHS
S
YGNID
V
L
Q
Q
---
AC
P
QEVWINPIDAQ
A
RGI
RH
GD
T
VRVFN
N
N
GE
M
L
IA
AKVTPRILPGV
T
A
I
GQGAW
L
K
A
D
M
F
GD
R
V
DHGGS
I
N
I
LT
S
H
RPSP
-
LAKGNP
S
HSNLV
Q
IEK
fig|595496.3.peg.1548
Escherichia coli BW2952 (5-797/798)
ISRR
S
L
M
K
T
SA
L
GSLALA
SSA
F
T
LPF
S
QM
VR
A
A
E
APV
-
E-
-
-
EK
A
VW
S
S
C
T
VNCGSRC
L
LRLHVKD
DT
V
Y
WVE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRR
-----
R
M
NHP
----
DRL
K
YPMKRVGKRGEGKFERISWDEALDTI
SDN
L
R
RI
L
K
D
YGNEAV
H
VL
Y
G
T
G
VD
GGN
I
T
N
S
---
-
NV
-
PY
RLMN
SC
GG
F
L
SR
YGSYSTAQIS
A
AM
S
Y
MF
G
A
-----
NDGNSP
D
DI
A
N
T
KLVVMFGNNPAET
------
RMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIVIDPRY
N
DTAA
--
GREDEWLPIRPGTD
G
AL
AC
A
IAWVLITEN
M
VDQPFLDKYCVGYDEKTLPA
N
AP
R
N
A
HYKAYILGEG
P
D
G
I
AKTP
E
WAA
K
IT
S
IP
AE
K
II
Q
LAREIG
S
AKPAYICQGWGPQR
H
S
NGEQT
S
RAIAML
SV
LTGNVGI
N
GGNSG
-----------
V
REG
SWDLGV
E
W
F
P
M
L
E
NPVKTQIS
V
F
T
WTDAIDHG
TE
MTA
T
R
-----
DGVR
---------
GKEKLDVPIKF
L
W
C
YA
S
NTL
I
NQH
G
DIN
H
THE
V
LQD
D
SKCEMIV
G
I
D
H
FMTASAKY
C
DILLPDLM
PT
EQEDLI
SHES
AGNMGY
V
I
LA
QPATS
A
KFERKPIYW
M
LSEVAKRLGPDVYQ
T
FTEGR
S
Q
HE
W
I
K
Y
L
H
----
AK
TK
E
R
N
P
E
MP
D
Y
E
E
M
K
TT
GI
F
---
K
K
K
C
P
E
EHYVA
F
R
AFR
E
DP
Q
ANPLKTPSGKIEIYS
ER
LAKIA
-------
D
TWEL
K
KDE
I
I
H
PLP
A
Y
TPG
FDGWD
D
P
L
R
K
T
Y
PLQL
T
GFHYK
A
RTHS
S
YGNID
V
L
Q
Q
---
AC
P
QEVWINPIDAQ
A
RGI
RH
GD
T
VRVFN
N
N
GE
M
L
IA
AKVTPRILPGV
T
A
I
GQGAW
L
K
A
D
M
F
GD
R
V
DHGGS
I
N
I
LT
S
H
RPSP
-
LAKGNP
S
HSNLV
Q
IEK
fig|536056.3.peg.2166
Escherichia coli DH1 (5-797/798)
ISRR
S
L
M
K
T
SA
L
GSLALA
SSA
F
T
LPF
S
QM
VR
A
A
E
APV
-
E-
-
-
EK
A
VW
S
S
C
T
VNCGSRC
L
LRLHVKD
DT
V
Y
WVE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRR
-----
R
M
NHP
----
DRL
K
YPMKRVGKRGEGKFERISWDEALDTI
SDN
L
R
RI
L
K
D
YGNEAV
H
VL
Y
G
T
G
VD
GGN
I
T
N
S
---
-
NV
-
PY
RLMN
SC
GG
F
L
SR
YGSYSTAQIS
A
AM
S
Y
MF
G
A
-----
NDGNSP
D
DI
A
N
T
KLVVMFGNNPAET
------
RMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIVIDPRY
N
DTAA
--
GREDEWLPIRPGTD
G
AL
AC
A
IAWVLITEN
M
VDQPFLDKYCVGYDEKTLPA
N
AP
R
N
A
HYKAYILGEG
P
D
G
I
AKTP
E
WAA
K
IT
S
IP
AE
K
II
Q
LAREIG
S
AKPAYICQGWGPQR
H
S
NGEQT
S
RAIAML
SV
LTGNVGI
N
GGNSG
-----------
V
REG
SWDLGV
E
W
F
P
M
L
E
NPVKTQIS
V
F
T
WTDAIDHG
TE
MTA
T
R
-----
DGVR
---------
GKEKLDVPIKF
L
W
C
YA
S
NTL
I
NQH
G
DIN
H
THE
V
LQD
D
SKCEMIV
G
I
D
H
FMTASAKY
C
DILLPDLM
PT
EQEDLI
SHES
AGNMGY
V
I
LA
QPATS
A
KFERKPIYW
M
LSEVAKRLGPDVYQ
T
FTEGR
S
Q
HE
W
I
K
Y
L
H
----
AK
TK
E
R
N
P
E
MP
D
Y
E
E
M
K
TT
GI
F
---
K
K
K
C
P
E
EHYVA
F
R
AFR
E
DP
Q
ANPLKTPSGKIEIYS
ER
LAKIA
-------
D
TWEL
K
KDE
I
I
H
PLP
A
Y
TPG
FDGWD
D
P
L
R
K
T
Y
PLQL
T
GFHYK
A
RTHS
S
YGNID
V
L
Q
Q
---
AC
P
QEVWINPIDAQ
A
RGI
RH
GD
T
VRVFN
N
N
GE
M
L
IA
AKVTPRILPGV
T
A
I
GQGAW
L
K
A
D
M
F
GD
R
V
DHGGS
I
N
I
LT
S
H
RPSP
-
LAKGNP
S
HSNLV
Q
IEK
fig|340186.3.peg.16
Escherichia coli E110019 (15-807/808)
ISRR
S
L
M
K
T
SA
L
GSLALA
SSA
F
T
LPF
S
QM
VR
A
A
E
APV
-
E-
-
-
EK
A
VW
S
S
C
T
VNCGSRC
L
LRLHVKD
DT
V
Y
WVE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRR
-----
R
M
NHP
----
DRL
K
YPMKRVGKRGEGKFERISWDEALDTI
SDN
L
R
RI
L
K
D
YGNEAV
H
VL
Y
G
T
G
VD
GGN
I
T
N
S
---
-
NV
-
PY
RLMN
SC
GG
F
L
SR
YGSYSTAQIS
A
AM
S
Y
MF
G
A
-----
NDGNSP
D
DI
A
N
T
KLVVMFGNNPAET
------
RMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIVIDPRY
N
DTAA
--
GREDEWLPIRPGTD
G
AL
AC
A
IAWVLITEN
M
VDQPFLDKYCVGYDEKTLPA
N
AP
R
N
A
HYKAYILGEG
P
D
G
I
AKTP
E
WAA
K
IT
S
IP
AE
K
II
Q
LAREIG
S
AKPAYICQGWGPQR
H
S
NGEQT
S
RAIAML
SV
LTGNVGI
N
GGNSG
-----------
V
REG
SWDLGV
E
W
F
P
M
L
E
NPVKTQIS
V
F
T
WTDAIDHG
TE
MTA
T
R
-----
DGVR
---------
GKEKLDVPIKF
L
W
C
YA
S
NTL
I
NQH
G
DIN
H
THE
V
LQD
D
SKCEMIV
G
I
D
H
FMTASAKY
C
DILLPDLM
PT
EQEDLI
SHES
AGNMGY
V
I
LA
QPATS
A
KFERKPIYW
M
LSEVAKRLGPDVYQ
T
FTEGR
S
Q
HE
W
I
K
Y
L
H
----
AK
TK
E
R
N
P
E
MP
D
Y
E
E
M
K
TT
GI
F
---
K
K
K
C
P
E
EHYVA
F
R
AFR
E
DP
Q
ANPLKTPSGKIEIYS
ER
LAKIA
-------
D
TWEL
K
KDE
I
I
H
PLP
A
Y
TPG
FDGWD
D
P
L
R
K
T
Y
PLQL
T
GFHYK
A
RTHS
S
YGNID
V
L
Q
Q
---
AC
P
QEVWINPIDAQ
A
RGI
RH
GD
T
VRVFN
N
N
GE
M
L
IA
AKVTPRILPGV
T
A
I
GQGAW
L
K
A
D
M
F
GD
R
V
DHGGS
I
N
I
LT
S
H
RPSP
-
LAKGNP
S
HSNLV
Q
IEK
fig|340186.5.peg.17
Escherichia coli E110019 (5-797/798)
ISRR
S
L
M
K
T
SA
L
GSLALA
SSA
F
T
LPF
S
QM
VR
A
A
E
APV
-
E-
-
-
EK
A
VW
S
S
C
T
VNCGSRC
L
LRLHVKD
DT
V
Y
WVE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRR
-----
R
M
NHP
----
DRL
K
YPMKRVGKRGEGKFERISWDEALDTI
SDN
L
R
RI
L
K
D
YGNEAV
H
VL
Y
G
T
G
VD
GGN
I
T
N
S
---
-
NV
-
PY
RLMN
SC
GG
F
L
SR
YGSYSTAQIS
A
AM
S
Y
MF
G
A
-----
NDGNSP
D
DI
A
N
T
KLVVMFGNNPAET
------
RMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIVIDPRY
N
DTAA
--
GREDEWLPIRPGTD
G
AL
AC
A
IAWVLITEN
M
VDQPFLDKYCVGYDEKTLPA
N
AP
R
N
A
HYKAYILGEG
P
D
G
I
AKTP
E
WAA
K
IT
S
IP
AE
K
II
Q
LAREIG
S
AKPAYICQGWGPQR
H
S
NGEQT
S
RAIAML
SV
LTGNVGI
N
GGNSG
-----------
V
REG
SWDLGV
E
W
F
P
M
L
E
NPVKTQIS
V
F
T
WTDAIDHG
TE
MTA
T
R
-----
DGVR
---------
GKEKLDVPIKF
L
W
C
YA
S
NTL
I
NQH
G
DIN
H
THE
V
LQD
D
SKCEMIV
G
I
D
H
FMTASAKY
C
DILLPDLM
PT
EQEDLI
SHES
AGNMGY
V
I
LA
QPATS
A
KFERKPIYW
M
LSEVAKRLGPDVYQ
T
FTEGR
S
Q
HE
W
I
K
Y
L
H
----
AK
TK
E
R
N
P
E
MP
D
Y
E
E
M
K
TT
GI
F
---
K
K
K
C
P
E
EHYVA
F
R
AFR
E
DP
Q
ANPLKTPSGKIEIYS
ER
LAKIA
-------
D
TWEL
K
KDE
I
I
H
PLP
A
Y
TPG
FDGWD
D
P
L
R
K
T
Y
PLQL
T
GFHYK
A
RTHS
S
YGNID
V
L
Q
Q
---
AC
P
QEVWINPIDAQ
A
RGI
RH
GD
T
VRVFN
N
N
GE
M
L
IA
AKVTPRILPGV
T
A
I
GQGAW
L
K
A
D
M
F
GD
R
V
DHGGS
I
N
I
LT
S
H
RPSP
-
LAKGNP
S
HSNLV
Q
IEK
fig|331111.12.peg.2082
Escherichia coli E24377A (15-807/808)
ISRR
S
L
M
K
T
SA
L
GSLALA
SSA
F
T
LPF
S
QM
VR
A
A
E
APV
-
E-
-
-
EK
A
VW
S
S
C
T
VNCGSRC
L
LRLHVKD
DT
V
Y
WVE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRR
-----
R
M
NHP
----
DRL
K
YPMKRVGKRGEGKFERISWDEALDTI
SDN
L
R
RI
L
K
D
YGNEAV
H
VL
Y
G
T
G
VD
GGN
I
T
N
S
---
-
NV
-
PY
RLMN
SC
GG
F
L
SR
YGSYSTAQIS
A
AM
S
Y
MF
G
A
-----
NDGNSP
D
DI
A
N
T
KLVVMFGNNPAET
------
RMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIVIDPRY
N
DTAA
--
GREDEWLPIRPGTD
G
AL
AC
A
IAWVLITEN
M
VDQPFLDKYCVGYDEKTLPA
N
AP
R
N
A
HYKAYILGEG
P
D
G
I
AKTP
E
WAA
K
IT
S
IP
AE
K
II
Q
LAREIG
S
AKPAYICQGWGPQR
H
S
NGEQT
S
RAIAML
SV
LTGNVGI
N
GGNSG
-----------
V
REG
SWDLGV
E
W
F
P
M
L
E
NPVKTQIS
V
F
T
WTDAIDHG
TE
MTA
T
R
-----
DGVR
---------
GKEKLDVPIKF
L
W
C
YA
S
NTL
I
NQH
G
DIN
H
THE
V
LQD
D
SKCEMIV
G
I
D
H
FMTASAKY
C
DILLPDLM
PT
EQEDLI
SHES
AGNMGY
V
I
LA
QPATS
A
KFERKPIYW
M
LSEVAKRLGPDVYQ
T
FTEGR
S
Q
HE
W
I
K
Y
L
H
----
AK
TK
E
R
N
P
E
MP
D
Y
E
E
M
K
TT
GI
F
---
K
K
K
C
P
E
EHYVA
F
R
AFR
E
DP
Q
ANPLKTPSGKIEIYS
ER
LAKIA
-------
D
TWEL
K
KDE
I
I
H
PLP
A
Y
TPG
FDGWD
D
P
L
R
K
T
Y
PLQL
T
GFHYK
A
RTHS
S
YGNID
V
L
Q
Q
---
AC
P
QEVWINPIDAQ
A
RGI
RH
GD
T
VRVFN
N
N
GE
M
L
IA
AKVTPRILPGV
T
A
I
GQGAW
L
K
A
D
M
F
GD
R
V
DHGGS
I
N
I
LT
S
H
RPSP
-
LAKGNP
S
HSNLV
Q
IEK
fig|331111.3.peg.4225
Escherichia coli E24377A (15-807/808)
ISRR
S
L
M
K
T
SA
L
GSLALA
SSA
F
T
LPF
S
QM
VR
A
A
E
APV
-
E-
-
-
EK
A
VW
S
S
C
T
VNCGSRC
L
LRLHVKD
DT
V
Y
WVE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRR
-----
R
M
NHP
----
DRL
K
YPMKRVGKRGEGKFERISWDEALDTI
SDN
L
R
RI
L
K
D
YGNEAV
H
VL
Y
G
T
G
VD
GGN
I
T
N
S
---
-
NV
-
PY
RLMN
SC
GG
F
L
SR
YGSYSTAQIS
A
AM
S
Y
MF
G
A
-----
NDGNSP
D
DI
A
N
T
KLVVMFGNNPAET
------
RMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIVIDPRY
N
DTAA
--
GREDEWLPIRPGTD
G
AL
AC
A
IAWVLITEN
M
VDQPFLDKYCVGYDEKTLPA
N
AP
R
N
A
HYKAYILGEG
P
D
G
I
AKTP
E
WAA
K
IT
S
IP
AE
K
II
Q
LAREIG
S
AKPAYICQGWGPQR
H
S
NGEQT
S
RAIAML
SV
LTGNVGI
N
GGNSG
-----------
V
REG
SWDLGV
E
W
F
P
M
L
E
NPVKTQIS
V
F
T
WTDAIDHG
TE
MTA
T
R
-----
DGVR
---------
GKEKLDVPIKF
L
W
C
YA
S
NTL
I
NQH
G
DIN
H
THE
V
LQD
D
SKCEMIV
G
I
D
H
FMTASAKY
C
DILLPDLM
PT
EQEDLI
SHES
AGNMGY
V
I
LA
QPATS
A
KFERKPIYW
M
LSEVAKRLGPDVYQ
T
FTEGR
S
Q
HE
W
I
K
Y
L
H
----
AK
TK
E
R
N
P
E
MP
D
Y
E
E
M
K
TT
GI
F
---
K
K
K
C
P
E
EHYVA
F
R
AFR
E
DP
Q
ANPLKTPSGKIEIYS
ER
LAKIA
-------
D
TWEL
K
KDE
I
I
H
PLP
A
Y
TPG
FDGWD
D
P
L
R
K
T
Y
PLQL
T
GFHYK
A
RTHS
S
YGNID
V
L
Q
Q
---
AC
P
QEVWINPIDAQ
A
RGI
RH
GD
T
VRVFN
N
N
GE
M
L
IA
AKVTPRILPGV
T
A
I
GQGAW
L
K
A
D
M
F
GD
R
V
DHGGS
I
N
I
LT
S
H
RPSP
-
LAKGNP
S
HSNLV
Q
IEK
fig|316401.4.peg.1868
Escherichia coli ETEC H10407 (15-807/808)
ISRR
S
L
M
K
T
SA
L
GSLALA
SSA
F
T
LPF
S
QM
VR
A
A
E
APV
-
E-
-
-
EK
A
VW
S
S
C
T
VNCGSRC
L
LRLHVKD
DT
V
Y
WVE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRR
-----
R
M
NHP
----
DRL
K
YPMKRVGKRGEGKFERISWDEALDTI
SDN
L
R
RI
L
K
D
YGNEAV
H
VL
Y
G
T
G
VD
GGN
I
T
N
S
---
-
NV
-
PY
RLMN
SC
GG
F
L
SR
YGSYSTAQIS
A
AM
S
Y
MF
G
A
-----
NDGNSP
D
DI
A
N
T
KLVVMFGNNPAET
------
RMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIVIDPRY
N
DTAA
--
GREDEWLPIRPGTD
G
AL
AC
A
IAWVLITEN
M
VDQPFLDKYCVGYDEKTLPA
N
AP
R
N
A
HYKAYILGEG
P
D
G
I
AKTP
E
WAA
K
IT
S
IP
AE
K
II
Q
LAREIG
S
AKPAYICQGWGPQR
H
S
NGEQT
S
RAIAML
SV
LTGNVGI
N
GGNSG
-----------
V
REG
SWDLGV
E
W
F
P
M
L
E
NPVKTQIS
V
F
T
WTDAIDHG
TE
MTA
T
R
-----
DGVR
---------
GKEKLDVPIKF
L
W
C
YA
S
NTL
I
NQH
G
DIN
H
THE
V
LQD
D
SKCEMIV
G
I
D
H
FMTASAKY
C
DILLPDLM
PT
EQEDLI
SHES
AGNMGY
V
I
LA
QPATS
A
KFERKPIYW
M
LSEVAKRLGPDVYQ
T
FTEGR
S
Q
HE
W
I
K
Y
L
H
----
AK
TK
E
R
N
P
E
MP
D
Y
E
E
M
K
TT
GI
F
---
K
K
K
C
P
E
EHYVA
F
R
AFR
E
DP
Q
ANPLKTPSGKIEIYS
ER
LAKIA
-------
D
TWEL
K
KDE
I
I
H
PLP
A
Y
TPG
FDGWD
D
P
L
R
K
T
Y
PLQL
T
GFHYK
A
RTHS
S
YGNID
V
L
Q
Q
---
AC
P
QEVWINPIDAQ
A
RGI
RH
GD
T
VRVFN
N
N
GE
M
L
IA
AKVTPRILPGV
T
A
I
GQGAW
L
K
A
D
M
F
GD
R
V
DHGGS
I
N
I
LT
S
H
RPSP
-
LAKGNP
S
HSNLV
Q
IEK
fig|316401.4.peg.1869
Escherichia coli ETEC H10407 (5-797/798)
ISRR
S
L
M
K
T
SA
L
GSLALA
SSA
F
T
LPF
S
QM
VR
A
A
E
APV
-
E-
-
-
EK
A
VW
S
S
C
T
VNCGSRC
L
LRLHVKD
DT
V
Y
WVE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRR
-----
R
M
NHP
----
DRL
K
YPMKRVGKRGEGKFERISWDEALDTI
SDN
L
R
RI
L
K
D
YGNEAV
H
VL
Y
G
T
G
VD
GGN
I
T
N
S
---
-
NV
-
PY
RLMN
SC
GG
F
L
SR
YGSYSTAQIS
A
AM
S
Y
MF
G
A
-----
NDGNSP
D
DI
A
N
T
KLVVMFGNNPAET
------
RMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIVIDPRY
N
DTAA
--
GREDEWLPIRPGTD
G
AL
AC
A
IAWVLITEN
M
VDQPFLDKYCVGYDEKTLPA
N
AP
R
N
A
HYKAYILGEG
P
D
G
I
AKTP
E
WAA
K
IT
S
IP
AE
K
II
Q
LAREIG
S
AKPAYICQGWGPQR
H
S
NGEQT
S
RAIAML
SV
LTGNVGI
N
GGNSG
-----------
V
REG
SWDLGV
E
W
F
P
M
L
E
NPVKTQIS
V
F
T
WTDAIDHG
TE
MTA
T
R
-----
DGVR
---------
GKEKLDVPIKF
L
W
C
YA
S
NTL
I
NQH
G
DIN
H
THE
V
LQD
D
SKCEMIV
G
I
D
H
FMTASAKY
C
DILLPDLM
PT
EQEDLI
SHES
AGNMGY
V
I
LA
QPATS
A
KFERKPIYW
M
LSEVAKRLGPDVYQ
T
FTEGR
S
Q
HE
W
I
K
Y
L
H
----
AK
TK
E
R
N
P
E
MP
D
Y
E
E
M
K
TT
GI
F
---
K
K
K
C
P
E
EHYVA
F
R
AFR
E
DP
Q
ANPLKTPSGKIEIYS
ER
LAKIA
-------
D
TWEL
K
KDE
I
I
H
PLP
A
Y
TPG
FDGWD
D
P
L
R
K
T
Y
PLQL
T
GFHYK
A
RTHS
S
YGNID
V
L
Q
Q
---
AC
P
QEVWINPIDAQ
A
RGI
RH
GD
T
VRVFN
N
N
GE
M
L
IA
AKVTPRILPGV
T
A
I
GQGAW
L
K
A
D
M
F
GD
R
V
DHGGS
I
N
I
LT
S
H
RPSP
-
LAKGNP
S
HSNLV
Q
IEK
fig|656408.3.peg.1727
Escherichia coli H591 (15-807/808)
ISRR
S
L
M
K
T
SA
L
GSLALA
SSA
F
T
LPF
S
QM
VR
A
A
E
APV
-
E-
-
-
EK
A
VW
S
S
C
T
VNCGSRC
L
LRLHVKD
DT
V
Y
WVE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRR
-----
R
M
NHP
----
DRL
K
YPMKRVGKRGEGKFERISWDEALDTI
SDN
L
R
RI
L
K
D
YGNEAV
H
VL
Y
G
T
G
VD
GGN
I
T
N
S
---
-
NV
-
PY
RLMN
SC
GG
F
L
SR
YGSYSTAQIS
A
AM
S
Y
MF
G
A
-----
NDGNSP
D
DI
A
N
T
KLVVMFGNNPAET
------
RMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIVIDPRY
N
DTAA
--
GREDEWLPIRPGTD
G
AL
AC
A
IAWVLITEN
M
VDQPFLDKYCVGYDEKTLPA
N
AP
R
N
A
HYKAYILGEG
P
D
G
I
AKTP
E
WAA
K
IT
S
IP
AE
K
II
Q
LAREIG
S
AKPAYICQGWGPQR
H
S
NGEQT
S
RAIAML
SV
LTGNVGI
N
GGNSG
-----------
V
REG
SWDLGV
E
W
F
P
M
L
E
NPVKTQIS
V
F
T
WTDAIDHG
TE
MTA
T
R
-----
DGVR
---------
GKEKLDVPIKF
L
W
C
YA
S
NTL
I
NQH
G
DIN
H
THE
V
LQD
D
SKCEMIV
G
I
D
H
FMTASAKY
C
DILLPDLM
PT
EQEDLI
SHES
AGNMGY
V
I
LA
QPATS
A
KFERKPIYW
M
LSEVAKRLGPDVYQ
T
FTEGR
S
Q
HE
W
I
K
Y
L
H
----
AK
TK
E
R
N
P
E
MP
D
Y
E
E
M
K
TT
GI
F
---
K
K
K
C
P
E
EHYVA
F
R
AFR
E
DP
Q
ANPLKTPSGKIEIYS
ER
LAKIA
-------
D
TWEL
K
KDE
I
I
H
PLP
A
Y
TPG
FDGWD
D
P
L
R
K
T
Y
PLQL
T
GFHYK
A
RTHS
S
YGNID
V
L
Q
Q
---
AC
P
QEVWINPIDAQ
A
RGI
RH
GD
T
VRVFN
N
N
GE
M
L
IA
AKVTPRILPGV
T
A
I
GQGAW
L
K
A
D
M
F
GD
R
V
DHGGS
I
N
I
LT
S
H
RPSP
-
LAKGNP
S
HSNLV
Q
IEK
fig|656408.3.peg.1728
Escherichia coli H591 (14-806/807)
ISRR
S
L
M
K
T
SA
L
GSLALA
SSA
F
T
LPF
S
QM
VR
A
A
E
APV
-
E-
-
-
EK
A
VW
S
S
C
T
VNCGSRC
L
LRLHVKD
DT
V
Y
WVE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRR
-----
R
M
NHP
----
DRL
K
YPMKRVGKRGEGKFERISWDEALDTI
SDN
L
R
RI
L
K
D
YGNEAV
H
VL
Y
G
T
G
VD
GGN
I
T
N
S
---
-
NV
-
PY
RLMN
SC
GG
F
L
SR
YGSYSTAQIS
A
AM
S
Y
MF
G
A
-----
NDGNSP
D
DI
A
N
T
KLVVMFGNNPAET
------
RMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIVIDPRY
N
DTAA
--
GREDEWLPIRPGTD
G
AL
AC
A
IAWVLITEN
M
VDQPFLDKYCVGYDEKTLPA
N
AP
R
N
A
HYKAYILGEG
P
D
G
I
AKTP
E
WAA
K
IT
S
IP
AE
K
II
Q
LAREIG
S
AKPAYICQGWGPQR
H
S
NGEQT
S
RAIAML
SV
LTGNVGI
N
GGNSG
-----------
V
REG
SWDLGV
E
W
F
P
M
L
E
NPVKTQIS
V
F
T
WTDAIDHG
TE
MTA
T
R
-----
DGVR
---------
GKEKLDVPIKF
L
W
C
YA
S
NTL
I
NQH
G
DIN
H
THE
V
LQD
D
SKCEMIV
G
I
D
H
FMTASAKY
C
DILLPDLM
PT
EQEDLI
SHES
AGNMGY
V
I
LA
QPATS
A
KFERKPIYW
M
LSEVAKRLGPDVYQ
T
FTEGR
S
Q
HE
W
I
K
Y
L
H
----
AK
TK
E
R
N
P
E
MP
D
Y
E
E
M
K
TT
GI
F
---
K
K
K
C
P
E
EHYVA
F
R
AFR
E
DP
Q
ANPLKTPSGKIEIYS
ER
LAKIA
-------
D
TWEL
K
KDE
I
I
H
PLP
A
Y
TPG
FDGWD
D
P
L
R
K
T
Y
PLQL
T
GFHYK
A
RTHS
S
YGNID
V
L
Q
Q
---
AC
P
QEVWINPIDAQ
A
RGI
RH
GD
T
VRVFN
N
N
GE
M
L
IA
AKVTPRILPGV
T
A
I
GQGAW
L
K
A
D
M
F
GD
R
V
DHGGS
I
N
I
LT
S
H
RPSP
-
LAKGNP
S
HSNLV
Q
IEK
fig|585034.4.peg.1622
Escherichia coli IAI1 (5-797/798)
ISRR
S
L
M
K
T
SA
L
GSLALA
SSA
F
T
LPF
S
QM
VR
A
A
E
APV
-
E-
-
-
EK
A
VW
S
S
C
T
VNCGSRC
L
LRLHVKD
DT
V
Y
WVE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRR
-----
R
M
NHP
----
DRL
K
YPMKRVGKRGEGKFERISWDEALDTI
SDN
L
R
RI
L
K
D
YGNEAV
H
VL
Y
G
T
G
VD
GGN
I
T
N
S
---
-
NV
-
PY
RLMN
SC
GG
F
L
SR
YGSYSTAQIS
A
AM
S
Y
MF
G
A
-----
NDGNSP
D
DI
A
N
T
KLVVMFGNNPAET
------
RMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIVIDPRY
N
DTAA
--
GREDEWLPIRPGTD
G
AL
AC
A
IAWVLITEN
M
VDQPFLDKYCVGYDEKTLPA
N
AP
R
N
A
HYKAYILGEG
P
D
G
I
AKTP
E
WAA
K
IT
S
IP
AE
K
II
Q
LAREIG
S
AKPAYICQGWGPQR
H
S
NGEQT
S
RAIAML
SV
LTGNVGI
N
GGNSG
-----------
V
REG
SWDLGV
E
W
F
P
M
L
E
NPVKTQIS
V
F
T
WTDAIDHG
TE
MTA
T
R
-----
DGVR
---------
GKEKLDVPIKF
L
W
C
YA
S
NTL
I
NQH
G
DIN
H
THE
V
LQ
N
D
SKCEMIV
G
I
D
H
FMTASAKY
C
DILLPDLM
PT
EQEDLI
SHES
AGNMGY
V
I
LA
QPATS
A
KFERKPIYW
M
LSEVAKRLGPDVYQ
T
FTEGR
S
Q
HE
W
I
K
Y
L
H
----
AK
TK
E
R
N
P
E
MP
D
Y
E
E
M
K
TT
GI
F
---
K
K
K
C
P
E
EHYVA
F
R
AFR
E
DP
Q
ANPLKTPSGKIEIYS
ER
LAKIA
-------
D
TWEL
K
KDE
I
I
H
PLP
A
Y
TPG
FDGWD
D
P
L
R
K
T
Y
PLQL
T
GFHYK
A
RTHS
S
YGNID
V
L
Q
Q
---
AC
P
QEVWINPIDAQ
A
RGI
RH
GD
T
VRVFN
N
N
GE
M
L
IA
AKVTPRILPGV
T
A
I
GQGAW
L
K
A
D
M
F
GD
R
V
DHGGS
I
N
I
LT
S
H
RPSP
-
LAKGNP
S
HSNLV
Q
IEK
fig|585034.5.peg.1617
Escherichia coli IAI1 (5-797/798)
ISRR
S
L
M
K
T
SA
L
GSLALA
SSA
F
T
LPF
S
QM
VR
A
A
E
APV
-
E-
-
-
EK
A
VW
S
S
C
T
VNCGSRC
L
LRLHVKD
DT
V
Y
WVE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRR
-----
R
M
NHP
----
DRL
K
YPMKRVGKRGEGKFERISWDEALDTI
SDN
L
R
RI
L
K
D
YGNEAV
H
VL
Y
G
T
G
VD
GGN
I
T
N
S
---
-
NV
-
PY
RLMN
SC
GG
F
L
SR
YGSYSTAQIS
A
AM
S
Y
MF
G
A
-----
NDGNSP
D
DI
A
N
T
KLVVMFGNNPAET
------
RMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIVIDPRY
N
DTAA
--
GREDEWLPIRPGTD
G
AL
AC
A
IAWVLITEN
M
VDQPFLDKYCVGYDEKTLPA
N
AP
R
N
A
HYKAYILGEG
P
D
G
I
AKTP
E
WAA
K
IT
S
IP
AE
K
II
Q
LAREIG
S
AKPAYICQGWGPQR
H
S
NGEQT
S
RAIAML
SV
LTGNVGI
N
GGNSG
-----------
V
REG
SWDLGV
E
W
F
P
M
L
E
NPVKTQIS
V
F
T
WTDAIDHG
TE
MTA
T
R
-----
DGVR
---------
GKEKLDVPIKF
L
W
C
YA
S
NTL
I
NQH
G
DIN
H
THE
V
LQ
N
D
SKCEMIV
G
I
D
H
FMTASAKY
C
DILLPDLM
PT
EQEDLI
SHES
AGNMGY
V
I
LA
QPATS
A
KFERKPIYW
M
LSEVAKRLGPDVYQ
T
FTEGR
S
Q
HE
W
I
K
Y
L
H
----
AK
TK
E
R
N
P
E
MP
D
Y
E
E
M
K
TT
GI
F
---
K
K
K
C
P
E
EHYVA
F
R
AFR
E
DP
Q
ANPLKTPSGKIEIYS
ER
LAKIA
-------
D
TWEL
K
KDE
I
I
H
PLP
A
Y
TPG
FDGWD
D
P
L
R
K
T
Y
PLQL
T
GFHYK
A
RTHS
S
YGNID
V
L
Q
Q
---
AC
P
QEVWINPIDAQ
A
RGI
RH
GD
T
VRVFN
N
N
GE
M
L
IA
AKVTPRILPGV
T
A
I
GQGAW
L
K
A
D
M
F
GD
R
V
DHGGS
I
N
I
LT
S
H
RPSP
-
LAKGNP
S
HSNLV
Q
IEK
fig|83333.1.peg.1574
Escherichia coli K12 (15-807/808)
ISRR
S
L
M
K
T
SA
L
GSLALA
SSA
F
T
LPF
S
QM
VR
A
A
E
APV
-
E-
-
-
EK
A
VW
S
S
C
T
VNCGSRC
L
LRLHVKD
DT
V
Y
WVE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRR
-----
R
M
NHP
----
DRL
K
YPMKRVGKRGEGKFERISWDEALDTI
SDN
L
R
RI
L
K
D
YGNEAV
H
VL
Y
G
T
G
VD
GGN
I
T
N
S
---
-
NV
-
PY
RLMN
SC
GG
F
L
SR
YGSYSTAQIS
A
AM
S
Y
MF
G
A
-----
NDGNSP
D
DI
A
N
T
KLVVMFGNNPAET
------
RMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIVIDPRY
N
DTAA
--
GREDEWLPIRPGTD
G
AL
AC
A
IAWVLITEN
M
VDQPFLDKYCVGYDEKTLPA
N
AP
R
N
A
HYKAYILGEG
P
D
G
I
AKTP
E
WAA
K
IT
S
IP
AE
K
II
Q
LAREIG
S
AKPAYICQGWGPQR
H
S
NGEQT
S
RAIAML
SV
LTGNVGI
N
GGNSG
-----------
V
REG
SWDLGV
E
W
F
P
M
L
E
NPVKTQIS
V
F
T
WTDAIDHG
TE
MTA
T
R
-----
DGVR
---------
GKEKLDVPIKF
L
W
C
YA
S
NTL
I
NQH
G
DIN
H
THE
V
LQD
D
SKCEMIV
G
I
D
H
FMTASAKY
C
DILLPDLM
PT
EQEDLI
SHES
AGNMGY
V
I
LA
QPATS
A
KFERKPIYW
M
LSEVAKRLGPDVYQ
T
FTEGR
S
Q
HE
W
I
K
Y
L
H
----
AK
TK
E
R
N
P
E
MP
D
Y
E
E
M
K
TT
GI
F
---
K
K
K
C
P
E
EHYVA
F
R
AFR
E
DP
Q
ANPLKTPSGKIEIYS
ER
LAKIA
-------
D
TWEL
K
KDE
I
I
H
PLP
A
Y
TPG
FDGWD
D
P
L
R
K
T
Y
PLQL
T
GFHYK
A
RTHS
S
YGNID
V
L
Q
Q
---
AC
P
QEVWINPIDAQ
A
RGI
RH
GD
T
VRVFN
N
N
GE
M
L
IA
AKVTPRILPGV
T
A
I
GQGAW
L
K
A
D
M
F
GD
R
V
DHGGS
I
N
I
LT
S
H
RPSP
-
LAKGNP
S
HSNLV
Q
IEK
fig|595495.4.peg.2852
Escherichia coli KO11 (5-797/798)
ISRR
S
L
M
K
T
SA
L
GSLALA
SSA
F
T
LPF
S
QM
VR
A
A
E
APV
-
E-
-
-
EK
A
VW
S
S
C
T
VNCGSRC
L
LRLHVKD
DT
V
Y
WVE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRR
-----
R
M
NHP
----
DRL
K
YPMKRVGKRGEGKFERISWDEALDTI
SDN
L
R
RI
L
K
D
YGNEAV
H
VL
Y
G
T
G
VD
GGN
I
T
N
S
---
-
NV
-
PY
RLMN
SC
GG
F
L
SR
YGSYSTAQIS
A
AM
S
Y
MF
G
A
-----
NDGNSP
D
DI
A
N
T
KLVVMFGNNPAET
------
RMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIVIDPRY
N
DTAA
--
GREDEWLPIRPGTD
G
AL
AC
A
IAWVLITEN
M
VDQPFLDKYCVGYDEKTLPA
N
AP
R
N
A
HYKAYILGEG
P
D
G
I
AKTP
E
WAA
K
IT
S
IP
AE
K
II
Q
LAREIG
S
AKPAYICQGWGPQR
H
S
NGEQT
S
RAIAML
SV
LTGNVGI
N
GGNSG
-----------
V
REG
SWDLGV
E
W
F
P
M
L
E
NPVKTQIS
V
F
T
WTDAIDHG
TE
MTA
T
R
-----
DGVR
---------
GKEKLDVPIKF
L
W
C
YA
S
NTL
I
NQH
G
DIN
H
THE
V
LQD
D
SKCEMIV
G
I
D
H
FMTASAKY
C
DILLPDLM
PT
EQEDLI
SHES
AGNMGY
V
I
LA
QPATS
A
KFERKPIYW
M
LSEVAKRLGPDVYQ
T
FTEGR
S
Q
HE
W
I
K
Y
L
H
----
AK
TK
E
R
N
P
E
MP
D
Y
E
E
M
K
TT
GI
F
---
K
K
K
C
P
E
EHYVA
F
R
AFR
E
DP
Q
ANPLKTPSGKIEIYS
ER
LAKIA
-------
D
TWEL
K
KDE
I
I
H
PLP
A
Y
TPG
FDGWD
D
P
L
R
K
T
Y
PLQL
T
GFHYK
A
RTHS
S
YGNID
V
L
Q
Q
---
AC
P
QEVWINPIDAQ
A
RGI
RH
GD
T
VRVFN
N
N
GE
M
L
IA
AKVTPRILPGV
T
A
I
GQGAW
L
K
A
D
M
F
GD
R
V
DHGGS
I
N
I
LT
S
H
RPSP
-
LAKGNP
S
HSNLV
Q
IEK
fig|679207.4.peg.4677
Escherichia coli MS 107-1 (15-807/808)
ISRR
S
L
M
K
T
SA
L
GSLALA
SSA
F
T
LPF
S
QM
VR
A
A
E
APV
-
E-
-
-
EK
A
VW
S
S
C
T
VNCGSRC
L
LRLHVKD
DT
V
Y
WVE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRR
-----
R
M
NHP
----
DRL
K
YPMKRVGKRGEGKFERISWDEALDTI
SDN
L
R
RI
L
K
D
YGNEAV
H
VL
Y
G
T
G
VD
GGN
I
T
N
S
---
-
NV
-
PY
RLMN
SC
GG
F
L
SR
YGSYSTAQIS
A
AM
S
Y
MF
G
A
-----
NDGNSP
D
DI
A
N
T
KLVVMFGNNPAET
------
RMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIVIDPRY
N
DTAA
--
GREDEWLPIRPGTD
G
AL
AC
A
IAWVLITEN
M
VDQPFLDKYCVGYDEKTLPA
N
AP
R
N
A
HYKAYILGEG
P
D
G
I
AKTP
E
WAA
K
IT
S
IP
AE
K
II
Q
LAREIG
S
AKPAYICQGWGPQR
H
S
NGEQT
S
RAIAML
SV
LTGNVGI
N
GGNSG
-----------
V
REG
SWDLGV
E
W
F
P
M
L
E
NPVKTQIS
V
F
T
WTDAIDHG
TE
MTA
T
R
-----
DGVR
---------
GKEKLDVPIKF
L
W
C
YA
S
NTL
I
NQH
G
DIN
H
THE
V
LQD
D
SKCEMIV
G
I
D
H
FMTASAKY
C
DILLPDLM
PT
EQEDLI
SHES
AGNMGY
V
I
LA
QPATS
A
KFERKPIYW
M
LSEVAKRLGPDVYQ
T
FTEGR
S
Q
HE
W
I
K
Y
L
H
----
AK
TK
E
R
N
P
E
MP
D
Y
E
E
M
K
TT
GI
F
---
K
K
K
C
P
E
EHYVA
F
R
AFR
E
DP
Q
ANPLKTPSGKIEIYS
ER
LAKIA
-------
D
TWEL
K
KDE
I
I
H
PLP
A
Y
TPG
FDGWD
D
P
L
R
K
T
Y
PLQL
T
GFHYK
A
RTHS
S
YGNID
V
L
Q
Q
---
AC
P
QEVWINPIDAQ
A
RGI
RH
GD
T
VRVFN
N
N
GE
M
L
IA
AKVTPRILPGV
T
A
I
GQGAW
L
K
A
D
M
F
GD
R
V
DHGGS
I
N
I
LT
S
H
RPSP
-
LAKGNP
S
HSNLV
Q
IEK
fig|679207.4.peg.4678
Escherichia coli MS 107-1 (5-797/798)
ISRR
S
L
M
K
T
SA
L
GSLALA
SSA
F
T
LPF
S
QM
VR
A
A
E
APV
-
E-
-
-
EK
A
VW
S
S
C
T
VNCGSRC
L
LRLHVKD
DT
V
Y
WVE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRR
-----
R
M
NHP
----
DRL
K
YPMKRVGKRGEGKFERISWDEALDTI
SDN
L
R
RI
L
K
D
YGNEAV
H
VL
Y
G
T
G
VD
GGN
I
T
N
S
---
-
NV
-
PY
RLMN
SC
GG
F
L
SR
YGSYSTAQIS
A
AM
S
Y
MF
G
A
-----
NDGNSP
D
DI
A
N
T
KLVVMFGNNPAET
------
RMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIVIDPRY
N
DTAA
--
GREDEWLPIRPGTD
G
AL
AC
A
IAWVLITEN
M
VDQPFLDKYCVGYDEKTLPA
N
AP
R
N
A
HYKAYILGEG
P
D
G
I
AKTP
E
WAA
K
IT
S
IP
AE
K
II
Q
LAREIG
S
AKPAYICQGWGPQR
H
S
NGEQT
S
RAIAML
SV
LTGNVGI
N
GGNSG
-----------
V
REG
SWDLGV
E
W
F
P
M
L
E
NPVKTQIS
V
F
T
WTDAIDHG
TE
MTA
T
R
-----
DGVR
---------
GKEKLDVPIKF
L
W
C
YA
S
NTL
I
NQH
G
DIN
H
THE
V
LQD
D
SKCEMIV
G
I
D
H
FMTASAKY
C
DILLPDLM
PT
EQEDLI
SHES
AGNMGY
V
I
LA
QPATS
A
KFERKPIYW
M
LSEVAKRLGPDVYQ
T
FTEGR
S
Q
HE
W
I
K
Y
L
H
----
AK
TK
E
R
N
P
E
MP
D
Y
E
E
M
K
TT
GI
F
---
K
K
K
C
P
E
EHYVA
F
R
AFR
E
DP
Q
ANPLKTPSGKIEIYS
ER
LAKIA
-------
D
TWEL
K
KDE
I
I
H
PLP
A
Y
TPG
FDGWD
D
P
L
R
K
T
Y
PLQL
T
GFHYK
A
RTHS
S
YGNID
V
L
Q
Q
---
AC
P
QEVWINPIDAQ
A
RGI
RH
GD
T
VRVFN
N
N
GE
M
L
IA
AKVTPRILPGV
T
A
I
GQGAW
L
K
A
D
M
F
GD
R
V
DHGGS
I
N
I
LT
S
H
RPSP
-
LAKGNP
S
HSNLV
Q
IEK
fig|749538.3.peg.4137
Escherichia coli MS 116-1 (5-797/798)
ISRR
S
L
M
K
T
SA
L
GSLALA
SSA
F
T
LPF
S
QM
VR
A
A
E
APV
-
E-
-
-
EK
A
VW
S
S
C
T
VNCGSRC
L
LRLHVKD
DT
V
Y
WVE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRR
-----
R
M
NHP
----
DRL
K
YPMKRVGKRGEGKFERISWDEALDTI
SDN
L
R
RI
L
K
D
YGNEAV
H
VL
Y
G
T
G
VD
GGN
I
T
N
S
---
-
NV
-
PY
RLMN
SC
GG
F
L
SR
YGSYSTAQIS
A
AM
S
Y
MF
G
A
-----
NDGNSP
D
DI
A
N
T
KLVVMFGNNPAET
------
RMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIVIDPRY
N
DTAA
--
GREDEWLPIRPGTD
G
AL
AC
A
IAWVLITEN
M
VDQPFLDKYCVGYDEKTLPA
N
AP
R
N
A
HYKAYILGEG
P
D
G
I
AKTP
E
WAA
K
IT
S
IP
AE
K
II
Q
LAREIG
S
AKPAYICQGWGPQR
H
S
NGEQT
S
RAIAML
SV
LTGNVGI
N
GGNSG
-----------
V
REG
SWDLGV
E
W
F
P
M
L
E
NPVKTQIS
V
F
T
WTDAIDHG
TE
MTA
T
R
-----
DGVR
---------
GKEKLDVPIKF
L
W
C
YA
S
NTL
I
NQH
G
DIN
H
THE
V
LQD
D
SKCEMIV
G
I
D
H
FMTASAKY
C
DILLPDLM
PT
EQEDLI
SHES
AGNMGY
V
I
LA
QPATS
A
KFERKPIYW
M
LSEVAKRLGPDVYQ
T
FTEGR
S
Q
HE
W
I
K
Y
L
H
----
AK
TK
E
R
N
P
E
MP
D
Y
E
E
M
K
TT
GI
F
---
K
K
K
C
P
E
EHYVA
F
R
AFR
E
DP
Q
ANPLKTPSGKIEIYS
ER
LAKIA
-------
D
TWEL
K
KDE
I
I
H
PLP
A
Y
TPG
FDGWD
D
P
L
R
K
T
Y
PLQL
T
GFHYK
A
RTHS
S
YGNID
V
L
Q
Q
---
AC
P
QEVWINPIDAQ
A
RGI
RH
GD
T
VRVFN
N
N
GE
M
L
IA
AKVTPRILPGV
T
A
I
GQGAW
L
K
A
D
M
F
GD
R
V
DHGGS
I
N
I
LT
S
H
RPSP
-
LAKGNP
S
HSNLV
Q
IEK
fig|679206.4.peg.1317
Escherichia coli MS 119-7 (5-797/798)
ISRR
S
L
M
K
T
SA
L
GSLALA
SSA
F
T
LPF
S
QM
VR
A
A
E
APV
-
E-
-
-
EK
A
VW
S
S
C
T
VNCGSRC
L
LRLHVKD
DT
V
Y
WVE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRR
-----
R
M
NHP
----
DRL
K
YPMKRVGKRGEGKFERISWDEALDTI
SDN
L
R
RI
L
K
D
YGNEAV
H
VL
Y
G
T
G
VD
GGN
I
T
N
S
---
-
NV
-
PY
RLMN
SC
GG
F
L
SR
YGSYSTAQIS
A
AM
S
Y
MF
G
A
-----
NDGNSP
D
DI
A
N
T
KLVVMFGNNPAET
------
RMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIVIDPRY
N
DTAA
--
GREDEWLPIRPGTD
G
AL
AC
A
IAWVLITEN
M
VDQPFLDKYCVGYDEKTLPA
N
AP
R
N
A
HYKAYILGEG
P
D
G
I
AKTP
E
WAA
K
IT
S
IP
AE
K
II
Q
LAREIG
S
AKPAYICQGWGPQR
H
S
NGEQT
S
RAIAML
SV
LTGNVGI
N
GGNSG
-----------
V
REG
SWDLGV
E
W
F
P
M
L
E
NPVKTQIS
V
F
T
WTDAIDHG
TE
MTA
T
R
-----
DGVR
---------
GKEKLDVPIKF
L
W
C
YA
S
NTL
I
NQH
G
DIN
H
THE
V
LQD
D
SKCEMIV
G
I
D
H
FMTASAKY
C
DILLPDLM
PT
EQEDLI
SHES
AGNMGY
V
I
LA
QPATS
A
KFERKPIYW
M
LSEVAKRLGPDVYQ
T
FTEGR
S
Q
HE
W
I
K
Y
L
H
----
AK
TK
E
R
N
P
E
MP
D
Y
E
E
M
K
TT
GI
F
---
K
K
K
C
P
E
EHYVA
F
R
AFR
E
DP
Q
ANPLKTPSGKIEIYS
ER
LAKIA
-------
D
TWEL
K
KDE
I
I
H
PLP
A
Y
TPG
FDGWD
D
P
L
R
K
T
Y
PLQL
T
GFHYK
A
RTHS
S
YGNID
V
L
Q
Q
---
AC
P
QEVWINPIDAQ
A
RGI
RH
GD
T
VRVFN
N
N
GE
M
L
IA
AKVTPRILPGV
T
A
I
GQGAW
L
K
A
D
M
F
GD
R
V
DHGGS
I
N
I
LT
S
H
RPSP
-
LAKGNP
S
HSNLV
Q
IEK
fig|679205.4.peg.1618
Escherichia coli MS 124-1 (15-807/808)
ISRR
S
L
M
K
T
SA
L
GSLALA
SSA
F
T
LPF
S
QM
VR
A
A
E
APV
-
E-
-
-
EK
A
VW
S
S
C
T
VNCGSRC
L
LRLHVKD
DT
V
Y
WVE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRR
-----
R
M
NHP
----
DRL
K
YPMKRVGKRGEGKFERISWDEALDTI
SDN
L
R
RI
L
K
D
YGNEAV
H
VL
Y
G
T
G
VD
GGN
I
T
N
S
---
-
NV
-
PY
RLMN
SC
GG
F
L
SR
YGSYSTAQIS
A
AM
S
Y
MF
G
A
-----
NDGNSP
D
DI
A
N
T
KLVVMFGNNPAET
------
RMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIVIDPRY
N
DTAA
--
GREDEWLPIRPGTD
G
AL
AC
A
IAWVLITEN
M
VDQPFLDKYCVGYDEKTLPA
N
AP
R
N
A
HYKAYILGEG
P
D
G
I
AKTP
E
WAA
K
IT
S
IP
AE
K
II
Q
LAREIG
S
AKPAYICQGWGPQR
H
S
NGEQT
S
RAIAML
SV
LTGNVGI
N
GGNSG
-----------
V
REG
SWDLGV
E
W
F
P
M
L
E
NPVKTQIS
V
F
T
WTDAIDHG
KE
MTA
T
R
-----
DGVR
---------
GKEKLDVPIKF
L
W
C
YA
S
NTL
I
NQH
G
DIN
H
THE
V
LQD
D
SKCEMIV
G
I
D
H
FMTASAKY
C
DILLPDLM
PT
EQEDLI
SHES
AGNMGY
V
I
LA
QPATS
A
KFERKPIYW
M
LSEVAKRLGPDVYQ
T
FTEGR
S
Q
HE
W
I
K
Y
L
H
----
AK
TK
E
R
N
P
E
MP
D
Y
E
E
M
K
TT
GI
F
---
K
K
K
C
P
E
EHYVA
F
R
AFR
E
DP
Q
ANPLKTPSGKIEIYS
ER
LAKIA
-------
D
TWEL
K
KDE
I
I
H
PLP
A
Y
TPG
FDGWD
D
P
L
R
K
T
Y
PLQL
T
GFHYK
A
RTHS
S
YGNID
V
L
Q
Q
---
AC
P
QEVWINPIDAQ
A
RGI
RH
GD
T
VRVFN
N
N
GE
M
L
IA
AKVTPRILPGV
T
A
I
GQGAW
L
K
A
D
M
F
GD
R
V
DHGGS
I
N
I
LT
S
H
RPSP
-
LAKGNP
S
HSNLV
Q
IEK
fig|679205.4.peg.1619
Escherichia coli MS 124-1 (5-797/798)
ISRR
S
L
M
K
T
SA
L
GSLALA
SSA
F
T
LPF
S
QM
VR
A
A
E
APV
-
E-
-
-
EK
A
VW
S
S
C
T
VNCGSRC
L
LRLHVKD
DT
V
Y
WVE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRR
-----
R
M
NHP
----
DRL
K
YPMKRVGKRGEGKFERISWDEALDTI
SDN
L
R
RI
L
K
D
YGNEAV
H
VL
Y
G
T
G
VD
GGN
I
T
N
S
---
-
NV
-
PY
RLMN
SC
GG
F
L
SR
YGSYSTAQIS
A
AM
S
Y
MF
G
A
-----
NDGNSP
D
DI
A
N
T
KLVVMFGNNPAET
------
RMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIVIDPRY
N
DTAA
--
GREDEWLPIRPGTD
G
AL
AC
A
IAWVLITEN
M
VDQPFLDKYCVGYDEKTLPA
N
AP
R
N
A
HYKAYILGEG
P
D
G
I
AKTP
E
WAA
K
IT
S
IP
AE
K
II
Q
LAREIG
S
AKPAYICQGWGPQR
H
S
NGEQT
S
RAIAML
SV
LTGNVGI
N
GGNSG
-----------
V
REG
SWDLGV
E
W
F
P
M
L
E
NPVKTQIS
V
F
T
WTDAIDHG
KE
MTA
T
R
-----
DGVR
---------
GKEKLDVPIKF
L
W
C
YA
S
NTL
I
NQH
G
DIN
H
THE
V
LQD
D
SKCEMIV
G
I
D
H
FMTASAKY
C
DILLPDLM
PT
EQEDLI
SHES
AGNMGY
V
I
LA
QPATS
A
KFERKPIYW
M
LSEVAKRLGPDVYQ
T
FTEGR
S
Q
HE
W
I
K
Y
L
H
----
AK
TK
E
R
N
P
E
MP
D
Y
E
E
M
K
TT
GI
F
---
K
K
K
C
P
E
EHYVA
F
R
AFR
E
DP
Q
ANPLKTPSGKIEIYS
ER
LAKIA
-------
D
TWEL
K
KDE
I
I
H
PLP
A
Y
TPG
FDGWD
D
P
L
R
K
T
Y
PLQL
T
GFHYK
A
RTHS
S
YGNID
V
L
Q
Q
---
AC
P
QEVWINPIDAQ
A
RGI
RH
GD
T
VRVFN
N
N
GE
M
L
IA
AKVTPRILPGV
T
A
I
GQGAW
L
K
A
D
M
F
GD
R
V
DHGGS
I
N
I
LT
S
H
RPSP
-
LAKGNP
S
HSNLV
Q
IEK
fig|749540.3.peg.4221
Escherichia coli MS 146-1 (15-807/808)
ISRR
S
L
M
K
T
SA
L
GSLALA
SSA
F
T
LPF
S
QM
VR
A
A
E
APV
-
E-
-
-
EK
A
VW
S
S
C
T
VNCGSRC
L
LRLHVKD
DT
V
Y
WVE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRR
-----
R
M
NHP
----
DRL
K
YPMKRVGKRGEGKFERISWDEALDTI
SDN
L
R
RI
L
K
D
YGNEAV
H
VL
Y
G
T
G
VD
GGN
I
T
N
S
---
-
NV
-
PY
RLMN
SC
GG
F
L
SR
YGSYSTAQIS
A
AM
S
Y
MF
G
A
-----
NDGNSP
D
DI
A
N
T
KLVVMFGNNPAET
------
RMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIVIDPRY
N
DTAA
--
GREDEWLPIRPGTD
G
AL
AC
A
IAWVLITEN
M
VDQPFLDKYCVGYDEKTLPA
N
AP
R
N
A
HYKAYILGEG
P
D
G
I
AKTP
E
WAA
K
IT
S
IP
AE
K
II
Q
LAREIG
S
AKPAYICQGWGPQR
H
S
NGEQT
S
RAIAML
SV
LTGNVGI
N
GGNSG
-----------
V
REG
SWDLGV
E
W
F
P
M
L
E
NPVKTQIS
V
F
T
WTDAIDHG
TE
MTA
T
R
-----
DGVR
---------
GKEKLDVPIKF
L
W
C
YA
S
NTL
I
NQH
G
DIN
H
THE
V
LQD
D
SKCEMIV
G
I
D
H
FMTASAKY
C
DILLPDLM
PT
EQEDLI
SHES
AGNMGY
V
I
LA
QPATS
A
KFERKPIYW
M
LSEVAKRLGPDVYQ
T
FTEGR
S
Q
HE
W
I
K
Y
L
H
----
AK
TK
E
R
N
P
E
MP
D
Y
E
E
M
K
TT
GI
F
---
K
K
K
C
P
E
EHYVA
F
R
AFR
E
DP
Q
ANPLKTPSGKIEIYS
ER
LAKIA
-------
D
TWEL
K
KDE
I
I
H
PLP
A
Y
TPG
FDGWD
D
P
L
R
K
T
Y
PLQL
T
GFHYK
A
RTHS
S
YGNID
V
L
Q
Q
---
AC
P
QEVWINPIDAQ
A
RGI
RH
GD
T
VRVFN
N
N
GE
M
L
IA
AKVTPRILPGV
T
A
I
GQGAW
L
K
A
D
M
F
GD
R
V
DHGGS
I
N
I
LT
S
H
RPSP
-
LAKGNP
S
HSNLV
Q
IEK
fig|749533.3.peg.4938
Escherichia coli MS 84-1 (5-797/798)
ISRR
S
L
M
K
T
SA
L
GSLALA
SSA
F
T
LPF
S
QM
VR
A
A
E
APV
-
E-
-
-
EK
A
VW
S
S
C
T
VNCGSRC
L
LRLHVKD
DT
V
Y
WVE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRR
-----
R
M
NHP
----
DRL
K
YPMKRVGKRGEGKFERISWDEALDTI
SDN
L
R
RI
L
K
D
YGNEAV
H
VL
Y
G
T
G
VD
GGN
I
T
N
S
---
-
NV
-
PY
RLMN
SC
GG
F
L
SR
YGSYSTAQIS
A
AM
S
Y
MF
G
A
-----
NDGNSP
D
DI
A
N
T
KLVVMFGNNPAET
------
RMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIVIDPRY
N
DTAA
--
GREDEWLPIRPGTD
G
AL
AC
A
IAWVLITEN
M
VDQPFLDKYCVGYDEKTLPA
N
AP
R
N
A
HYKAYILGEG
P
D
G
I
AKTP
E
WAA
K
IT
S
IP
AE
K
II
Q
LAREIG
S
AKPAYICQGWGPQR
H
S
NGEQT
S
RAIAML
SV
LTGNVGI
N
GGNSG
-----------
V
REG
SWDLGV
E
W
F
P
M
L
E
NPVKTQIS
V
F
T
WTDAIDHG
KE
MTA
T
R
-----
DGVR
---------
GKEKLDVPIKF
L
W
C
YA
S
NTL
I
NQH
G
DIN
H
THE
V
LQD
D
SKCEMIV
G
I
D
H
FMTASAKY
C
DILLPDLM
PT
EQEDLI
SHES
AGNMGY
V
I
LA
QPATS
A
KFERKPIYW
M
LSEVAKRLGPDVYQ
T
FTEGR
S
Q
HE
W
I
K
Y
L
H
----
AK
TK
E
R
N
P
E
MP
D
Y
E
E
M
K
TT
GI
F
---
K
K
K
C
P
E
EHYVA
F
R
AFR
E
DP
Q
ANPLKTPSGKIEIYS
ER
LAKIA
-------
D
TWEL
K
KDE
I
I
H
PLP
A
Y
TPG
FDGWD
D
P
L
R
K
T
Y
PLQL
T
GFHYK
A
RTHS
S
YGNID
V
L
Q
Q
---
AC
P
QEVWINPIDAQ
A
RGI
RH
GD
T
VRVFN
N
N
GE
M
L
IA
AKVTPRILPGV
T
A
I
GQGAW
L
K
A
D
M
F
GD
R
V
DHGGS
I
N
I
LT
S
H
RPSP
-
LAKGNP
S
HSNLV
Q
IEK
fig|656443.3.peg.2236
Escherichia coli TA271 (5-797/798)
ISRR
S
L
M
K
T
SA
L
GSLALA
SSA
F
T
LPF
S
QM
VR
A
A
E
APV
-
E-
-
-
EK
A
VW
S
S
C
T
VNCGSRC
L
LRLHVKD
DT
V
Y
WVE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRR
-----
R
M
NHP
----
DRL
K
YPMKRVGKRGEGKFERISWDEALDTI
SDN
L
R
RI
L
K
D
YGNEAV
H
VL
Y
G
T
G
VD
GGN
I
T
N
S
---
-
NV
-
PY
RLMN
SC
GG
F
L
SR
YGSYSTAQIS
A
AM
S
Y
MF
G
A
-----
NDGNSP
D
DI
A
N
T
KLVVMFGNNPAET
------
RMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIVIDPRY
N
DTAA
--
GREDEWLPIRPGTD
G
AL
AC
A
IAWVLITEN
M
VDQPFLDKYCVGYDEKTLPA
N
AP
R
N
A
HYKAYILGEG
P
D
G
I
AKTP
E
WAA
K
IT
S
IP
AE
K
II
Q
LAREIG
S
AKPAYICQGWGPQR
H
S
NGEQT
S
RAIAML
SV
LTGNVGI
N
GGNSG
-----------
V
REG
SWDLGV
E
W
F
P
M
L
E
NPVKTQIS
V
F
T
WTDAIDHG
TE
MTA
T
R
-----
DGVR
---------
GKEKLDVPIKF
L
W
C
YA
S
NTL
I
NQH
G
DIN
H
THE
V
LQD
D
SKCEMIV
G
I
D
H
FMTASAKY
C
DILLPDLM
PT
EQEDLI
SHES
AGNMGY
V
I
LA
QPATS
A
KFERKPIYW
M
LSEVAKRLGPDVYQ
T
FTEGR
S
Q
HE
W
I
K
Y
L
H
----
AK
TK
E
R
N
P
E
MP
D
Y
E
E
M
K
TT
GI
F
---
K
K
K
C
P
E
EHYVA
F
R
AFR
E
DP
Q
ANPLKTPSGKIEIYS
ER
LAKIA
-------
D
TWEL
K
KDE
I
I
H
PLP
A
Y
TPG
FDGWD
D
P
L
R
K
T
Y
PLQL
T
GFHYK
A
RTHS
S
YGNID
V
L
Q
Q
---
AC
P
QEVWINPIDAQ
A
RGI
RH
GD
T
VRVFN
N
N
GE
M
L
IA
AKVTPRILPGV
T
A
I
GQGAW
L
K
A
D
M
F
GD
R
V
DHGGS
I
N
I
LT
S
H
RPSP
-
LAKGNP
S
HSNLV
Q
IEK
fig|566546.3.peg.1065
Escherichia coli W (5-797/798)
ISRR
S
L
M
K
T
SA
L
GSLALA
SSA
F
T
LPF
S
QM
VR
A
A
E
APV
-
E-
-
-
EK
A
VW
S
S
C
T
VNCGSRC
L
LRLHVKD
DT
V
Y
WVE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRR
-----
R
M
NHP
----
DRL
K
YPMKRVGKRGEGKFERISWDEALDTI
SDN
L
R
RI
L
K
D
YGNEAV
H
VL
Y
G
T
G
VD
GGN
I
T
N
S
---
-
NV
-
PY
RLMN
SC
GG
F
L
SR
YGSYSTAQIS
A
AM
S
Y
MF
G
A
-----
NDGNSP
D
DI
A
N
T
KLVVMFGNNPAET
------
RMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIVIDPRY
N
DTAA
--
GREDEWLPIRPGTD
G
AL
AC
A
IAWVLITEN
M
VDQPFLDKYCVGYDEKTLPA
N
AP
R
N
A
HYKAYILGEG
P
D
G
I
AKTP
E
WAA
K
IT
S
IP
AE
K
II
Q
LAREIG
S
AKPAYICQGWGPQR
H
S
NGEQT
S
RAIAML
SV
LTGNVGI
N
GGNSG
-----------
V
REG
SWDLGV
E
W
F
P
M
L
E
NPVKTQIS
V
F
T
WTDAIDHG
TE
MTA
T
R
-----
DGVR
---------
GKEKLDVPIKF
L
W
C
YA
S
NTL
I
NQH
G
DIN
H
THE
V
LQD
D
SKCEMIV
G
I
D
H
FMTASAKY
C
DILLPDLM
PT
EQEDLI
SHES
AGNMGY
V
I
LA
QPATS
A
KFERKPIYW
M
LSEVAKRLGPDVYQ
T
FTEGR
S
Q
HE
W
I
K
Y
L
H
----
AK
TK
E
R
N
P
E
MP
D
Y
E
E
M
K
TT
GI
F
---
K
K
K
C
P
E
EHYVA
F
R
AFR
E
DP
Q
ANPLKTPSGKIEIYS
ER
LAKIA
-------
D
TWEL
K
KDE
I
I
H
PLP
A
Y
TPG
FDGWD
D
P
L
R
K
T
Y
PLQL
T
GFHYK
A
RTHS
S
YGNID
V
L
Q
Q
---
AC
P
QEVWINPIDAQ
A
RGI
RH
GD
T
VRVFN
N
N
GE
M
L
IA
AKVTPRILPGV
T
A
I
GQGAW
L
K
A
D
M
F
GD
R
V
DHGGS
I
N
I
LT
S
H
RPSP
-
LAKGNP
S
HSNLV
Q
IEK
fig|566546.4.peg.1740
Escherichia coli W (5-797/798)
ISRR
S
L
M
K
T
SA
L
GSLALA
SSA
F
T
LPF
S
QM
VR
A
A
E
APV
-
E-
-
-
EK
A
VW
S
S
C
T
VNCGSRC
L
LRLHVKD
DT
V
Y
WVE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRR
-----
R
M
NHP
----
DRL
K
YPMKRVGKRGEGKFERISWDEALDTI
SDN
L
R
RI
L
K
D
YGNEAV
H
VL
Y
G
T
G
VD
GGN
I
T
N
S
---
-
NV
-
PY
RLMN
SC
GG
F
L
SR
YGSYSTAQIS
A
AM
S
Y
MF
G
A
-----
NDGNSP
D
DI
A
N
T
KLVVMFGNNPAET
------
RMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIVIDPRY
N
DTAA
--
GREDEWLPIRPGTD
G
AL
AC
A
IAWVLITEN
M
VDQPFLDKYCVGYDEKTLPA
N
AP
R
N
A
HYKAYILGEG
P
D
G
I
AKTP
E
WAA
K
IT
S
IP
AE
K
II
Q
LAREIG
S
AKPAYICQGWGPQR
H
S
NGEQT
S
RAIAML
SV
LTGNVGI
N
GGNSG
-----------
V
REG
SWDLGV
E
W
F
P
M
L
E
NPVKTQIS
V
F
T
WTDAIDHG
TE
MTA
T
R
-----
DGVR
---------
GKEKLDVPIKF
L
W
C
YA
S
NTL
I
NQH
G
DIN
H
THE
V
LQD
D
SKCEMIV
G
I
D
H
FMTASAKY
C
DILLPDLM
PT
EQEDLI
SHES
AGNMGY
V
I
LA
QPATS
A
KFERKPIYW
M
LSEVAKRLGPDVYQ
T
FTEGR
S
Q
HE
W
I
K
Y
L
H
----
AK
TK
E
R
N
P
E
MP
D
Y
E
E
M
K
TT
GI
F
---
K
K
K
C
P
E
EHYVA
F
R
AFR
E
DP
Q
ANPLKTPSGKIEIYS
ER
LAKIA
-------
D
TWEL
K
KDE
I
I
H
PLP
A
Y
TPG
FDGWD
D
P
L
R
K
T
Y
PLQL
T
GFHYK
A
RTHS
S
YGNID
V
L
Q
Q
---
AC
P
QEVWINPIDAQ
A
RGI
RH
GD
T
VRVFN
N
N
GE
M
L
IA
AKVTPRILPGV
T
A
I
GQGAW
L
K
A
D
M
F
GD
R
V
DHGGS
I
N
I
LT
S
H
RPSP
-
LAKGNP
S
HSNLV
Q
IEK
fig|316407.3.peg.1545
Escherichia coli W3110 (14-806/807)
ISRR
S
L
M
K
T
SA
L
GSLALA
SSA
F
T
LPF
S
QM
VR
A
A
E
APV
-
E-
-
-
EK
A
VW
S
S
C
T
VNCGSRC
L
LRLHVKD
DT
V
Y
WVE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRR
-----
R
M
NHP
----
DRL
K
YPMKRVGKRGEGKFERISWDEALDTI
SDN
L
R
RI
L
K
D
YGNEAV
H
VL
Y
G
T
G
VD
GGN
I
T
N
S
---
-
NV
-
PY
RLMN
SC
GG
F
L
SR
YGSYSTAQIS
A
AM
S
Y
MF
G
A
-----
NDGNSP
D
DI
A
N
T
KLVVMFGNNPAET
------
RMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIVIDPRY
N
DTAA
--
GREDEWLPIRPGTD
G
AL
AC
A
IAWVLITEN
M
VDQPFLDKYCVGYDEKTLPA
N
AP
R
N
A
HYKAYILGEG
P
D
G
I
AKTP
E
WAA
K
IT
S
IP
AE
K
II
Q
LAREIG
S
AKPAYICQGWGPQR
H
S
NGEQT
S
RAIAML
SV
LTGNVGI
N
GGNSG
-----------
V
REG
SWDLGV
E
W
F
P
M
L
E
NPVKTQIS
V
F
T
WTDAIDHG
TE
MTA
T
R
-----
DGVR
---------
GKEKLDVPIKF
L
W
C
YA
S
NTL
I
NQH
G
DIN
H
THE
V
LQD
D
SKCEMIV
G
I
D
H
FMTASAKY
C
DILLPDLM
PT
EQEDLI
SHES
AGNMGY
V
I
LA
QPATS
A
KFERKPIYW
M
LSEVAKRLGPDVYQ
T
FTEGR
S
Q
HE
W
I
K
Y
L
H
----
AK
TK
E
R
N
P
E
MP
D
Y
E
E
M
K
TT
GI
F
---
K
K
K
C
P
E
EHYVA
F
R
AFR
E
DP
Q
ANPLKTPSGKIEIYS
ER
LAKIA
-------
D
TWEL
K
KDE
I
I
H
PLP
A
Y
TPG
FDGWD
D
P
L
R
K
T
Y
PLQL
T
GFHYK
A
RTHS
S
YGNID
V
L
Q
Q
---
AC
P
QEVWINPIDAQ
A
RGI
RH
GD
T
VRVFN
N
N
GE
M
L
IA
AKVTPRILPGV
T
A
I
GQGAW
L
K
A
D
M
F
GD
R
V
DHGGS
I
N
I
LT
S
H
RPSP
-
LAKGNP
S
HSNLV
Q
IEK
fig|316385.5.peg.1700
Escherichia coli str. K-12 substr. DH10B (14-806/807)
ISRR
S
L
M
K
T
SA
L
GSLALA
SSA
F
T
LPF
S
QM
VR
A
A
E
APV
-
E-
-
-
EK
A
VW
S
S
C
T
VNCGSRC
L
LRLHVKD
DT
V
Y
WVE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRR
-----
R
M
NHP
----
DRL
K
YPMKRVGKRGEGKFERISWDEALDTI
SDN
L
R
RI
L
K
D
YGNEAV
H
VL
Y
G
T
G
VD
GGN
I
T
N
S
---
-
NV
-
PY
RLMN
SC
GG
F
L
SR
YGSYSTAQIS
A
AM
S
Y
MF
G
A
-----
NDGNSP
D
DI
A
N
T
KLVVMFGNNPAET
------
RMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIVIDPRY
N
DTAA
--
GREDEWLPIRPGTD
G
AL
AC
A
IAWVLITEN
M
VDQPFLDKYCVGYDEKTLPA
N
AP
R
N
A
HYKAYILGEG
P
D
G
I
AKTP
E
WAA
K
IT
S
IP
AE
K
II
Q
LAREIG
S
AKPAYICQGWGPQR
H
S
NGEQT
S
RAIAML
SV
LTGNVGI
N
GGNSG
-----------
V
REG
SWDLGV
E
W
F
P
M
L
E
NPVKTQIS
V
F
T
WTDAIDHG
TE
MTA
T
R
-----
DGVR
---------
GKEKLDVPIKF
L
W
C
YA
S
NTL
I
NQH
G
DIN
H
THE
V
LQD
D
SKCEMIV
G
I
D
H
FMTASAKY
C
DILLPDLM
PT
EQEDLI
SHES
AGNMGY
V
I
LA
QPATS
A
KFERKPIYW
M
LSEVAKRLGPDVYQ
T
FTEGR
S
Q
HE
W
I
K
Y
L
H
----
AK
TK
E
R
N
P
E
MP
D
Y
E
E
M
K
TT
GI
F
---
K
K
K
C
P
E
EHYVA
F
R
AFR
E
DP
Q
ANPLKTPSGKIEIYS
ER
LAKIA
-------
D
TWEL
K
KDE
I
I
H
PLP
A
Y
TPG
FDGWD
D
P
L
R
K
T
Y
PLQL
T
GFHYK
A
RTHS
S
YGNID
V
L
Q
Q
---
AC
P
QEVWINPIDAQ
A
RGI
RH
GD
T
VRVFN
N
N
GE
M
L
IA
AKVTPRILPGV
T
A
I
GQGAW
L
K
A
D
M
F
GD
R
V
DHGGS
I
N
I
LT
S
H
RPSP
-
LAKGNP
S
HSNLV
Q
IEK
fig|316385.7.peg.1745
Escherichia coli str. K-12 substr. DH10B (5-797/798)
ISRR
S
L
M
K
T
SA
L
GSLALA
SSA
F
T
LPF
S
QM
VR
A
A
E
APV
-
E-
-
-
EK
A
VW
S
S
C
T
VNCGSRC
L
LRLHVKD
DT
V
Y
WVE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRR
-----
R
M
NHP
----
DRL
K
YPMKRVGKRGEGKFERISWDEALDTI
SDN
L
R
RI
L
K
D
YGNEAV
H
VL
Y
G
T
G
VD
GGN
I
T
N
S
---
-
NV
-
PY
RLMN
SC
GG
F
L
SR
YGSYSTAQIS
A
AM
S
Y
MF
G
A
-----
NDGNSP
D
DI
A
N
T
KLVVMFGNNPAET
------
RMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIVIDPRY
N
DTAA
--
GREDEWLPIRPGTD
G
AL
AC
A
IAWVLITEN
M
VDQPFLDKYCVGYDEKTLPA
N
AP
R
N
A
HYKAYILGEG
P
D
G
I
AKTP
E
WAA
K
IT
S
IP
AE
K
II
Q
LAREIG
S
AKPAYICQGWGPQR
H
S
NGEQT
S
RAIAML
SV
LTGNVGI
N
GGNSG
-----------
V
REG
SWDLGV
E
W
F
P
M
L
E
NPVKTQIS
V
F
T
WTDAIDHG
TE
MTA
T
R
-----
DGVR
---------
GKEKLDVPIKF
L
W
C
YA
S
NTL
I
NQH
G
DIN
H
THE
V
LQD
D
SKCEMIV
G
I
D
H
FMTASAKY
C
DILLPDLM
PT
EQEDLI
SHES
AGNMGY
V
I
LA
QPATS
A
KFERKPIYW
M
LSEVAKRLGPDVYQ
T
FTEGR
S
Q
HE
W
I
K
Y
L
H
----
AK
TK
E
R
N
P
E
MP
D
Y
E
E
M
K
TT
GI
F
---
K
K
K
C
P
E
EHYVA
F
R
AFR
E
DP
Q
ANPLKTPSGKIEIYS
ER
LAKIA
-------
D
TWEL
K
KDE
I
I
H
PLP
A
Y
TPG
FDGWD
D
P
L
R
K
T
Y
PLQL
T
GFHYK
A
RTHS
S
YGNID
V
L
Q
Q
---
AC
P
QEVWINPIDAQ
A
RGI
RH
GD
T
VRVFN
N
N
GE
M
L
IA
AKVTPRILPGV
T
A
I
GQGAW
L
K
A
D
M
F
GD
R
V
DHGGS
I
N
I
LT
S
H
RPSP
-
LAKGNP
S
HSNLV
Q
IEK
fig|511145.12.peg.1659
Escherichia coli str. K-12 substr. MG1655 (15-807/808)
ISRR
S
L
M
K
T
SA
L
GSLALA
SSA
F
T
LPF
S
QM
VR
A
A
E
APV
-
E-
-
-
EK
A
VW
S
S
C
T
VNCGSRC
L
LRLHVKD
DT
V
Y
WVE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRR
-----
R
M
NHP
----
DRL
K
YPMKRVGKRGEGKFERISWDEALDTI
SDN
L
R
RI
L
K
D
YGNEAV
H
VL
Y
G
T
G
VD
GGN
I
T
N
S
---
-
NV
-
PY
RLMN
SC
GG
F
L
SR
YGSYSTAQIS
A
AM
S
Y
MF
G
A
-----
NDGNSP
D
DI
A
N
T
KLVVMFGNNPAET
------
RMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIVIDPRY
N
DTAA
--
GREDEWLPIRPGTD
G
AL
AC
A
IAWVLITEN
M
VDQPFLDKYCVGYDEKTLPA
N
AP
R
N
A
HYKAYILGEG
P
D
G
I
AKTP
E
WAA
K
IT
S
IP
AE
K
II
Q
LAREIG
S
AKPAYICQGWGPQR
H
S
NGEQT
S
RAIAML
SV
LTGNVGI
N
GGNSG
-----------
V
REG
SWDLGV
E
W
F
P
M
L
E
NPVKTQIS
V
F
T
WTDAIDHG
TE
MTA
T
R
-----
DGVR
---------
GKEKLDVPIKF
L
W
C
YA
S
NTL
I
NQH
G
DIN
H
THE
V
LQD
D
SKCEMIV
G
I
D
H
FMTASAKY
C
DILLPDLM
PT
EQEDLI
SHES
AGNMGY
V
I
LA
QPATS
A
KFERKPIYW
M
LSEVAKRLGPDVYQ
T
FTEGR
S
Q
HE
W
I
K
Y
L
H
----
AK
TK
E
R
N
P
E
MP
D
Y
E
E
M
K
TT
GI
F
---
K
K
K
C
P
E
EHYVA
F
R
AFR
E
DP
Q
ANPLKTPSGKIEIYS
ER
LAKIA
-------
D
TWEL
K
KDE
I
I
H
PLP
A
Y
TPG
FDGWD
D
P
L
R
K
T
Y
PLQL
T
GFHYK
A
RTHS
S
YGNID
V
L
Q
Q
---
AC
P
QEVWINPIDAQ
A
RGI
RH
GD
T
VRVFN
N
N
GE
M
L
IA
AKVTPRILPGV
T
A
I
GQGAW
L
K
A
D
M
F
GD
R
V
DHGGS
I
N
I
LT
S
H
RPSP
-
LAKGNP
S
HSNLV
Q
IEK
fig|511145.6.peg.1643
Escherichia coli str. K-12 substr. MG1655 (5-797/798)
ISRR
S
L
M
K
T
SA
L
GSLALA
SSA
F
T
LPF
S
QM
VR
A
A
E
APV
-
E-
-
-
EK
A
VW
S
S
C
T
VNCGSRC
L
LRLHVKD
DT
V
Y
WVE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRR
-----
R
M
NHP
----
DRL
K
YPMKRVGKRGEGKFERISWDEALDTI
SDN
L
R
RI
L
K
D
YGNEAV
H
VL
Y
G
T
G
VD
GGN
I
T
N
S
---
-
NV
-
PY
RLMN
SC
GG
F
L
SR
YGSYSTAQIS
A
AM
S
Y
MF
G
A
-----
NDGNSP
D
DI
A
N
T
KLVVMFGNNPAET
------
RMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIVIDPRY
N
DTAA
--
GREDEWLPIRPGTD
G
AL
AC
A
IAWVLITEN
M
VDQPFLDKYCVGYDEKTLPA
N
AP
R
N
A
HYKAYILGEG
P
D
G
I
AKTP
E
WAA
K
IT
S
IP
AE
K
II
Q
LAREIG
S
AKPAYICQGWGPQR
H
S
NGEQT
S
RAIAML
SV
LTGNVGI
N
GGNSG
-----------
V
REG
SWDLGV
E
W
F
P
M
L
E
NPVKTQIS
V
F
T
WTDAIDHG
TE
MTA
T
R
-----
DGVR
---------
GKEKLDVPIKF
L
W
C
YA
S
NTL
I
NQH
G
DIN
H
THE
V
LQD
D
SKCEMIV
G
I
D
H
FMTASAKY
C
DILLPDLM
PT
EQEDLI
SHES
AGNMGY
V
I
LA
QPATS
A
KFERKPIYW
M
LSEVAKRLGPDVYQ
T
FTEGR
S
Q
HE
W
I
K
Y
L
H
----
AK
TK
E
R
N
P
E
MP
D
Y
E
E
M
K
TT
GI
F
---
K
K
K
C
P
E
EHYVA
F
R
AFR
E
DP
Q
ANPLKTPSGKIEIYS
ER
LAKIA
-------
D
TWEL
K
KDE
I
I
H
PLP
A
Y
TPG
FDGWD
D
P
L
R
K
T
Y
PLQL
T
GFHYK
A
RTHS
S
YGNID
V
L
Q
Q
---
AC
P
QEVWINPIDAQ
A
RGI
RH
GD
T
VRVFN
N
N
GE
M
L
IA
AKVTPRILPGV
T
A
I
GQGAW
L
K
A
D
M
F
GD
R
V
DHGGS
I
N
I
LT
S
H
RPSP
-
LAKGNP
S
HSNLV
Q
IEK
fig|562.371.peg.4431
Escherichia coli 1044A (5-797/798)
ISRR
S
L
M
K
T
SA
L
GSLALA
SSA
F
T
LPF
S
QM
VR
A
A
E
APV
-
E-
-
-
EK
A
VW
S
S
C
T
VNCGSRC
L
LRLHVKD
DT
V
Y
WVE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRR
-----
R
M
NHP
----
DRL
K
YPMKRVGKRGEGKFERISWDEALDTI
SDN
L
R
RI
L
K
D
YGNEAV
H
VL
Y
G
T
G
VD
GGN
I
T
N
S
---
-
NV
-
PY
RLMN
SC
GG
F
L
SR
YGSYSTAQIS
A
AM
S
Y
MF
G
A
-----
NDGNSP
D
DI
A
N
T
KLVVMFGNNPAET
------
RMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIVIDPRY
N
DTAA
--
GREDEWLPIRPGTD
G
AL
AC
A
IAWVLI
S
EN
M
VDQPFLDKYCVGYDEKTLPA
N
AP
R
N
A
HYKAYILGEG
P
D
G
I
AKTP
E
WAA
K
IT
S
IP
AE
K
II
Q
LAREIG
S
AKPAYICQGWGPQR
H
S
NGEQT
S
RAIAML
SV
LTGNVGI
N
GGNSG
-----------
V
REG
SWDLGV
E
W
F
P
M
L
E
NPVKTQIS
V
F
T
WTDAIDHG
TE
MTA
T
R
-----
DGVR
---------
GKEKLDVPIKF
L
W
C
YA
S
NTL
I
NQH
G
DIN
H
T
N
E
V
LQD
D
SKCEMIV
G
I
D
H
FMTASAKY
C
DILLPDLM
PT
EQEDLI
SHES
AGNMGY
V
I
LA
QPATS
A
KFERKPIYW
M
LSEVAKRLGPDVYQ
T
FTEGR
S
Q
HE
W
I
K
Y
L
H
----
AK
TK
E
R
N
P
E
MP
D
Y
E
E
M
K
TT
GI
F
---
K
K
K
C
P
E
EHYVA
F
R
AFR
E
DP
Q
ANPLKTPSGKIEIYS
ER
LAKIA
-------
D
TWEL
K
KDE
I
I
H
PLP
A
Y
TPG
FDGWD
D
P
L
R
K
T
Y
PLQL
T
GFHYK
A
RTHS
S
YGNID
V
L
Q
Q
---
AC
P
QEVWINPIDAQ
A
RGI
RH
GD
T
VRVFN
N
N
GE
M
L
IA
AKVTPRILPGV
T
A
I
GQGAW
L
K
A
D
M
F
GD
R
V
DHGGS
I
N
I
LT
S
H
RPSP
-
LAKGNP
S
HSNLV
Q
IEK
fig|562.373.peg.5333
Escherichia coli 1125A (15-807/808)
ISRR
S
L
M
K
T
SA
L
GSLALA
SSA
F
T
LPF
S
QM
VR
A
A
E
APV
-
E-
-
-
EK
A
VW
S
S
C
T
VNCGSRC
L
LRLHVKD
DT
V
Y
WVE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRR
-----
R
M
NHP
----
DRL
K
YPMKRVGKRGEGKFERISWDEALDTI
SDN
L
R
RI
L
K
D
YGNEAV
H
VL
Y
G
T
G
VD
GGN
I
T
N
S
---
-
NV
-
PY
RLMN
SC
GG
F
L
SR
YGSYSTAQIS
A
AM
S
Y
MF
G
A
-----
NDGNSP
D
DI
A
N
T
KLVVMFGNNPAET
------
RMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIVIDPRY
N
DTAA
--
GREDEWLPIRPGTD
G
AL
AC
A
IAWVLI
S
EN
M
VDQPFLDKYCVGYDEKTLPA
N
AP
R
N
A
HYKAYILGEG
P
D
G
I
AKTP
E
WAA
K
IT
S
IP
AE
K
II
Q
LAREIG
S
AKPAYICQGWGPQR
H
S
NGEQT
S
RAIAML
SV
LTGNVGI
N
GGNSG
-----------
V
REG
SWDLGV
E
W
F
P
M
L
E
NPVKTQIS
V
F
T
WTDAIDHG
TE
MTA
T
R
-----
DGVR
---------
GKEKLDVPIKF
L
W
C
YA
S
NTL
I
NQH
G
DIN
H
T
N
E
V
LQD
D
SKCEMIV
G
I
D
H
FMTASAKY
C
DILLPDLM
PT
EQEDLI
SHES
AGNMGY
V
I
LA
QPATS
A
KFERKPIYW
M
LSEVAKRLGPDVYQ
T
FTEGR
S
Q
HE
W
I
K
Y
L
H
----
AK
TK
E
R
N
P
E
MP
D
Y
E
E
M
K
TT
GI
F
---
K
K
K
C
P
E
EHYVA
F
R
AFR
E
DP
Q
ANPLKTPSGKIEIYS
ER
LAKIA
-------
D
TWEL
K
KDE
I
I
H
PLP
A
Y
TPG
FDGWD
D
P
L
R
K
T
Y
PLQL
T
GFHYK
A
RTHS
S
YGNID
V
L
Q
Q
---
AC
P
QEVWINPIDAQ
A
RGI
RH
GD
T
VRVFN
N
N
GE
M
L
IA
AKVTPRILPGV
T
A
I
GQGAW
L
K
A
D
M
F
GD
R
V
DHGGS
I
N
I
LT
S
H
RPSP
-
LAKGNP
S
HSNLV
Q
IEK
fig|562.372.peg.4663
Escherichia coli 1212A (15-807/808)
ISRR
S
L
M
K
T
SA
L
GSLALA
SSA
F
T
LPF
S
QM
VR
A
A
E
APV
-
E-
-
-
EK
A
VW
S
S
C
T
VNCGSRC
L
LRLHVKD
DT
V
Y
WVE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRR
-----
R
M
NHP
----
DRL
K
YPMKRVGKRGEGKFERISWDEALDTI
SDN
L
R
RI
L
K
D
YGNEAV
H
VL
Y
G
T
G
VD
GGN
I
T
N
S
---
-
NV
-
PY
RLMN
SC
GG
F
L
SR
YGSYSTAQIS
A
AM
S
Y
MF
G
A
-----
NDGNSP
D
DI
A
N
T
KLVVMFGNNPAET
------
RMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIVIDPRY
N
DTAA
--
GREDEWLPIRPGTD
G
AL
AC
A
IAWVLI
S
EN
M
VDQPFLDKYCVGYDEKTLPA
N
AP
R
N
A
HYKAYILGEG
P
D
G
I
AKTP
E
WAA
K
IT
S
IP
AE
K
II
Q
LAREIG
S
AKPAYICQGWGPQR
H
S
NGEQT
S
RAIAML
SV
LTGNVGI
N
GGNSG
-----------
V
REG
SWDLGV
E
W
F
P
M
L
E
NPVKTQIS
V
F
T
WTDAIDHG
TE
MTA
T
R
-----
DGVR
---------
GKEKLDVPIKF
L
W
C
YA
S
NTL
I
NQH
G
DIN
H
T
N
E
V
LQD
D
SKCEMIV
G
I
D
H
FMTASAKY
C
DILLPDLM
PT
EQEDLI
SHES
AGNMGY
V
I
LA
QPATS
A
KFERKPIYW
M
LSEVAKRLGPDVYQ
T
FTEGR
S
Q
HE
W
I
K
Y
L
H
----
AK
TK
E
R
N
P
E
MP
D
Y
E
E
M
K
TT
GI
F
---
K
K
K
C
P
E
EHYVA
F
R
AFR
E
DP
Q
ANPLKTPSGKIEIYS
ER
LAKIA
-------
D
TWEL
K
KDE
I
I
H
PLP
A
Y
TPG
FDGWD
D
P
L
R
K
T
Y
PLQL
T
GFHYK
A
RTHS
S
YGNID
V
L
Q
Q
---
AC
P
QEVWINPIDAQ
A
RGI
RH
GD
T
VRVFN
N
N
GE
M
L
IA
AKVTPRILPGV
T
A
I
GQGAW
L
K
A
D
M
F
GD
R
V
DHGGS
I
N
I
LT
S
H
RPSP
-
LAKGNP
S
HSNLV
Q
IEK
fig|562.372.peg.4664
Escherichia coli 1212A (5-797/798)
ISRR
S
L
M
K
T
SA
L
GSLALA
SSA
F
T
LPF
S
QM
VR
A
A
E
APV
-
E-
-
-
EK
A
VW
S
S
C
T
VNCGSRC
L
LRLHVKD
DT
V
Y
WVE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRR
-----
R
M
NHP
----
DRL
K
YPMKRVGKRGEGKFERISWDEALDTI
SDN
L
R
RI
L
K
D
YGNEAV
H
VL
Y
G
T
G
VD
GGN
I
T
N
S
---
-
NV
-
PY
RLMN
SC
GG
F
L
SR
YGSYSTAQIS
A
AM
S
Y
MF
G
A
-----
NDGNSP
D
DI
A
N
T
KLVVMFGNNPAET
------
RMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIVIDPRY
N
DTAA
--
GREDEWLPIRPGTD
G
AL
AC
A
IAWVLI
S
EN
M
VDQPFLDKYCVGYDEKTLPA
N
AP
R
N
A
HYKAYILGEG
P
D
G
I
AKTP
E
WAA
K
IT
S
IP
AE
K
II
Q
LAREIG
S
AKPAYICQGWGPQR
H
S
NGEQT
S
RAIAML
SV
LTGNVGI
N
GGNSG
-----------
V
REG
SWDLGV
E
W
F
P
M
L
E
NPVKTQIS
V
F
T
WTDAIDHG
TE
MTA
T
R
-----
DGVR
---------
GKEKLDVPIKF
L
W
C
YA
S
NTL
I
NQH
G
DIN
H
T
N
E
V
LQD
D
SKCEMIV
G
I
D
H
FMTASAKY
C
DILLPDLM
PT
EQEDLI
SHES
AGNMGY
V
I
LA
QPATS
A
KFERKPIYW
M
LSEVAKRLGPDVYQ
T
FTEGR
S
Q
HE
W
I
K
Y
L
H
----
AK
TK
E
R
N
P
E
MP
D
Y
E
E
M
K
TT
GI
F
---
K
K
K
C
P
E
EHYVA
F
R
AFR
E
DP
Q
ANPLKTPSGKIEIYS
ER
LAKIA
-------
D
TWEL
K
KDE
I
I
H
PLP
A
Y
TPG
FDGWD
D
P
L
R
K
T
Y
PLQL
T
GFHYK
A
RTHS
S
YGNID
V
L
Q
Q
---
AC
P
QEVWINPIDAQ
A
RGI
RH
GD
T
VRVFN
N
N
GE
M
L
IA
AKVTPRILPGV
T
A
I
GQGAW
L
K
A
D
M
F
GD
R
V
DHGGS
I
N
I
LT
S
H
RPSP
-
LAKGNP
S
HSNLV
Q
IEK
fig|562.374.peg.4446
Escherichia coli 536A (15-807/808)
ISRR
S
L
M
K
T
SA
L
GSLALA
SSA
F
T
LPF
S
QM
VR
A
A
E
APV
-
E-
-
-
EK
A
VW
S
S
C
T
VNCGSRC
L
LRLHVKD
DT
V
Y
WVE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRR
-----
R
M
NHP
----
DRL
K
YPMKRVGKRGEGKFERISWDEALDTI
SDN
L
R
RI
L
K
D
YGNEAV
H
VL
Y
G
T
G
VD
GGN
I
T
N
S
---
-
NV
-
PY
RLMN
SC
GG
F
L
SR
YGSYSTAQIS
A
AM
S
Y
MF
G
A
-----
NDGNSP
D
DI
A
N
T
KLVVMFGNNPAET
------
RMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIVIDPRY
N
DTAA
--
GREDEWLPIRPGTD
G
AL
AC
A
IAWVLI
S
EN
M
VDQPFLDKYCVGYDEKTLPA
N
AP
R
N
A
HYKAYILGEG
P
D
G
I
AKTP
E
WAA
K
IT
S
IP
AE
K
II
Q
LAREIG
S
AKPAYICQGWGPQR
H
S
NGEQT
S
RAIAML
SV
LTGNVGI
N
GGNSG
-----------
V
REG
SWDLGV
E
W
F
P
M
L
E
NPVKTQIS
V
F
T
WTDAIDHG
TE
MTA
T
R
-----
DGVR
---------
GKEKLDVPIKF
L
W
C
YA
S
NTL
I
NQH
G
DIN
H
T
N
E
V
LQD
D
SKCEMIV
G
I
D
H
FMTASAKY
C
DILLPDLM
PT
EQEDLI
SHES
AGNMGY
V
I
LA
QPATS
A
KFERKPIYW
M
LSEVAKRLGPDVYQ
T
FTEGR
S
Q
HE
W
I
K
Y
L
H
----
AK
TK
E
R
N
P
E
MP
D
Y
E
E
M
K
TT
GI
F
---
K
K
K
C
P
E
EHYVA
F
R
AFR
E
DP
Q
ANPLKTPSGKIEIYS
ER
LAKIA
-------
D
TWEL
K
KDE
I
I
H
PLP
A
Y
TPG
FDGWD
D
P
L
R
K
T
Y
PLQL
T
GFHYK
A
RTHS
S
YGNID
V
L
Q
Q
---
AC
P
QEVWINPIDAQ
A
RGI
RH
GD
T
VRVFN
N
N
GE
M
L
IA
AKVTPRILPGV
T
A
I
GQGAW
L
K
A
D
M
F
GD
R
V
DHGGS
I
N
I
LT
S
H
RPSP
-
LAKGNP
S
HSNLV
Q
IEK
fig|83334.1.peg.2323
Escherichia coli O157:H7 (15-807/808)
ISRR
S
L
M
K
T
SA
L
GSLALA
SSA
F
T
LPF
S
QM
VR
A
A
E
APV
-
E-
-
-
EK
A
VW
S
S
C
T
VNCGSRC
L
LRLHVKD
DT
V
Y
WVE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRR
-----
R
M
NHP
----
DRL
K
YPMKRVGKRGEGKFERISWDEALDTI
SDN
L
R
RI
L
K
D
YGNEAV
H
VL
Y
G
T
G
VD
GGN
I
T
N
S
---
-
NV
-
PY
RLMN
SC
GG
F
L
SR
YGSYSTAQIS
A
AM
S
Y
MF
G
A
-----
NDGNSP
D
DI
A
N
T
KLVVMFGNNPAET
------
RMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIVIDPRY
N
DTAA
--
GREDEWLPIRPGTD
G
AL
AC
A
IAWVLI
S
EN
M
VDQPFLDKYCVGYDEKTLPA
N
AP
R
N
A
HYKAYILGEG
P
D
G
I
AKTP
E
WAA
K
IT
S
IP
AE
K
II
Q
LAREIG
S
AKPAYICQGWGPQR
H
S
NGEQT
S
RAIAML
SV
LTGNVGI
N
GGNSG
-----------
V
REG
SWDLGV
E
W
F
P
M
L
E
NPVKTQIS
V
F
T
WTDAIDHG
TE
MTA
T
R
-----
DGVR
---------
GKEKLDVPIKF
L
W
C
YA
S
NTL
I
NQH
G
DIN
H
T
N
E
V
LQD
D
SKCEMIV
G
I
D
H
FMTASAKY
C
DILLPDLM
PT
EQEDLI
SHES
AGNMGY
V
I
LA
QPATS
A
KFERKPIYW
M
LSEVAKRLGPDVYQ
T
FTEGR
S
Q
HE
W
I
K
Y
L
H
----
AK
TK
E
R
N
P
E
MP
D
Y
E
E
M
K
TT
GI
F
---
K
K
K
C
P
E
EHYVA
F
R
AFR
E
DP
Q
ANPLKTPSGKIEIYS
ER
LAKIA
-------
D
TWEL
K
KDE
I
I
H
PLP
A
Y
TPG
FDGWD
D
P
L
R
K
T
Y
PLQL
T
GFHYK
A
RTHS
S
YGNID
V
L
Q
Q
---
AC
P
QEVWINPIDAQ
A
RGI
RH
GD
T
VRVFN
N
N
GE
M
L
IA
AKVTPRILPGV
T
A
I
GQGAW
L
K
A
D
M
F
GD
R
V
DHGGS
I
N
I
LT
S
H
RPSP
-
LAKGNP
S
HSNLV
Q
IEK
fig|444454.5.peg.5572
Escherichia coli O157:H7 str. EC4024 (14-806/807)
ISRR
S
L
M
K
T
SA
L
GSLALA
SSA
F
T
LPF
S
QM
VR
A
A
E
APV
-
E-
-
-
EK
A
VW
S
S
C
T
VNCGSRC
L
LRLHVKD
DT
V
Y
WVE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRR
-----
R
M
NHP
----
DRL
K
YPMKRVGKRGEGKFERISWDEALDTI
SDN
L
R
RI
L
K
D
YGNEAV
H
VL
Y
G
T
G
VD
GGN
I
T
N
S
---
-
NV
-
PY
RLMN
SC
GG
F
L
SR
YGSYSTAQIS
A
AM
S
Y
MF
G
A
-----
NDGNSP
D
DI
A
N
T
KLVVMFGNNPAET
------
RMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIVIDPRY
N
DTAA
--
GREDEWLPIRPGTD
G
AL
AC
A
IAWVLI
S
EN
M
VDQPFLDKYCVGYDEKTLPA
N
AP
R
N
A
HYKAYILGEG
P
D
G
I
AKTP
E
WAA
K
IT
S
IP
AE
K
II
Q
LAREIG
S
AKPAYICQGWGPQR
H
S
NGEQT
S
RAIAML
SV
LTGNVGI
N
GGNSG
-----------
V
REG
SWDLGV
E
W
F
P
M
L
E
NPVKTQIS
V
F
T
WTDAIDHG
TE
MTA
T
R
-----
DGVR
---------
GKEKLDVPIKF
L
W
C
YA
S
NTL
I
NQH
G
DIN
H
T
N
E
V
LQD
D
SKCEMIV
G
I
D
H
FMTASAKY
C
DILLPDLM
PT
EQEDLI
SHES
AGNMGY
V
I
LA
QPATS
A
KFERKPIYW
M
LSEVAKRLGPDVYQ
T
FTEGR
S
Q
HE
W
I
K
Y
L
H
----
AK
TK
E
R
N
P
E
MP
D
Y
E
E
M
K
TT
GI
F
---
K
K
K
C
P
E
EHYVA
F
R
AFR
E
DP
Q
ANPLKTPSGKIEIYS
ER
LAKIA
-------
D
TWEL
K
KDE
I
I
H
PLP
A
Y
TPG
FDGWD
D
P
L
R
K
T
Y
PLQL
T
GFHYK
A
RTHS
S
YGNID
V
L
Q
Q
---
AC
P
QEVWINPIDAQ
A
RGI
RH
GD
T
VRVFN
N
N
GE
M
L
IA
AKVTPRILPGV
T
A
I
GQGAW
L
K
A
D
M
F
GD
R
V
DHGGS
I
N
I
LT
S
H
RPSP
-
LAKGNP
S
HSNLV
Q
IEK
fig|444449.5.peg.518
Escherichia coli O157:H7 str. EC4042 (15-807/808)
ISRR
S
L
M
K
T
SA
L
GSLALA
SSA
F
T
LPF
S
QM
VR
A
A
E
APV
-
E-
-
-
EK
A
VW
S
S
C
T
VNCGSRC
L
LRLHVKD
DT
V
Y
WVE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRR
-----
R
M
NHP
----
DRL
K
YPMKRVGKRGEGKFERISWDEALDTI
SDN
L
R
RI
L
K
D
YGNEAV
H
VL
Y
G
T
G
VD
GGN
I
T
N
S
---
-
NV
-
PY
RLMN
SC
GG
F
L
SR
YGSYSTAQIS
A
AM
S
Y
MF
G
A
-----
NDGNSP
D
DI
A
N
T
KLVVMFGNNPAET
------
RMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIVIDPRY
N
DTAA
--
GREDEWLPIRPGTD
G
AL
AC
A
IAWVLI
S
EN
M
VDQPFLDKYCVGYDEKTLPA
N
AP
R
N
A
HYKAYILGEG
P
D
G
I
AKTP
E
WAA
K
IT
S
IP
AE
K
II
Q
LAREIG
S
AKPAYICQGWGPQR
H
S
NGEQT
S
RAIAML
SV
LTGNVGI
N
GGNSG
-----------
V
REG
SWDLGV
E
W
F
P
M
L
E
NPVKTQIS
V
F
T
WTDAIDHG
TE
MTA
T
R
-----
DGVR
---------
GKEKLDVPIKF
L
W
C
YA
S
NTL
I
NQH
G
DIN
H
T
N
E
V
LQD
D
SKCEMIV
G
I
D
H
FMTASAKY
C
DILLPDLM
PT
EQEDLI
SHES
AGNMGY
V
I
LA
QPATS
A
KFERKPIYW
M
LSEVAKRLGPDVYQ
T
FTEGR
S
Q
HE
W
I
K
Y
L
H
----
AK
TK
E
R
N
P
E
MP
D
Y
E
E
M
K
TT
GI
F
---
K
K
K
C
P
E
EHYVA
F
R
AFR
E
DP
Q
ANPLKTPSGKIEIYS
ER
LAKIA
-------
D
TWEL
K
KDE
I
I
H
PLP
A
Y
TPG
FDGWD
D
P
L
R
K
T
Y
PLQL
T
GFHYK
A
RTHS
S
YGNID
V
L
Q
Q
---
AC
P
QEVWINPIDAQ
A
RGI
RH
GD
T
VRVFN
N
N
GE
M
L
IA
AKVTPRILPGV
T
A
I
GQGAW
L
K
A
D
M
F
GD
R
V
DHGGS
I
N
I
LT
S
H
RPSP
-
LAKGNP
S
HSNLV
Q
IEK
fig|444448.5.peg.4826
Escherichia coli O157:H7 str. EC4045 (15-807/808)
ISRR
S
L
M
K
T
SA
L
GSLALA
SSA
F
T
LPF
S
QM
VR
A
A
E
APV
-
E-
-
-
EK
A
VW
S
S
C
T
VNCGSRC
L
LRLHVKD
DT
V
Y
WVE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRR
-----
R
M
NHP
----
DRL
K
YPMKRVGKRGEGKFERISWDEALDTI
SDN
L
R
RI
L
K
D
YGNEAV
H
VL
Y
G
T
G
VD
GGN
I
T
N
S
---
-
NV
-
PY
RLMN
SC
GG
F
L
SR
YGSYSTAQIS
A
AM
S
Y
MF
G
A
-----
NDGNSP
D
DI
A
N
T
KLVVMFGNNPAET
------
RMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIVIDPRY
N
DTAA
--
GREDEWLPIRPGTD
G
AL
AC
A
IAWVLI
S
EN
M
VDQPFLDKYCVGYDEKTLPA
N
AP
R
N
A
HYKAYILGEG
P
D
G
I
AKTP
E
WAA
K
IT
S
IP
AE
K
II
Q
LAREIG
S
AKPAYICQGWGPQR
H
S
NGEQT
S
RAIAML
SV
LTGNVGI
N
GGNSG
-----------
V
REG
SWDLGV
E
W
F
P
M
L
E
NPVKTQIS
V
F
T
WTDAIDHG
TE
MTA
T
R
-----
DGVR
---------
GKEKLDVPIKF
L
W
C
YA
S
NTL
I
NQH
G
DIN
H
T
N
E
V
LQD
D
SKCEMIV
G
I
D
H
FMTASAKY
C
DILLPDLM
PT
EQEDLI
SHES
AGNMGY
V
I
LA
QPATS
A
KFERKPIYW
M
LSEVAKRLGPDVYQ
T
FTEGR
S
Q
HE
W
I
K
Y
L
H
----
AK
TK
E
R
N
P
E
MP
D
Y
E
E
M
K
TT
GI
F
---
K
K
K
C
P
E
EHYVA
F
R
AFR
E
DP
Q
ANPLKTPSGKIEIYS
ER
LAKIA
-------
D
TWEL
K
KDE
I
I
H
PLP
A
Y
TPG
FDGWD
D
P
L
R
K
T
Y
PLQL
T
GFHYK
A
RTHS
S
YGNID
V
L
Q
Q
---
AC
P
QEVWINPIDAQ
A
RGI
RH
GD
T
VRVFN
N
N
GE
M
L
IA
AKVTPRILPGV
T
A
I
GQGAW
L
K
A
D
M
F
GD
R
V
DHGGS
I
N
I
LT
S
H
RPSP
-
LAKGNP
S
HSNLV
Q
IEK
fig|444453.5.peg.4691
Escherichia coli O157:H7 str. EC4076 (15-807/808)
ISRR
S
L
M
K
T
SA
L
GSLALA
SSA
F
T
LPF
S
QM
VR
A
A
E
APV
-
E-
-
-
EK
A
VW
S
S
C
T
VNCGSRC
L
LRLHVKD
DT
V
Y
WVE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRR
-----
R
M
NHP
----
DRL
K
YPMKRVGKRGEGKFERISWDEALDTI
SDN
L
R
RI
L
K
D
YGNEAV
H
VL
Y
G
T
G
VD
GGN
I
T
N
S
---
-
NV
-
PY
RLMN
SC
GG
F
L
SR
YGSYSTAQIS
A
AM
S
Y
MF
G
A
-----
NDGNSP
D
DI
A
N
T
KLVVMFGNNPAET
------
RMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIVIDPRY
N
DTAA
--
GREDEWLPIRPGTD
G
AL
AC
A
IAWVLI
S
EN
M
VDQPFLDKYCVGYDEKTLPA
N
AP
R
N
A
HYKAYILGEG
P
D
G
I
AKTP
E
WAA
K
IT
S
IP
AE
K
II
Q
LAREIG
S
AKPAYICQGWGPQR
H
S
NGEQT
S
RAIAML
SV
LTGNVGI
N
GGNSG
-----------
V
REG
SWDLGV
E
W
F
P
M
L
E
NPVKTQIS
V
F
T
WTDAIDHG
TE
MTA
T
R
-----
DGVR
---------
GKEKLDVPIKF
L
W
C
YA
S
NTL
I
NQH
G
DIN
H
T
N
E
V
LQD
D
SKCEMIV
G
I
D
H
FMTASAKY
C
DILLPDLM
PT
EQEDLI
SHES
AGNMGY
V
I
LA
QPATS
A
KFERKPIYW
M
LSEVAKRLGPDVYQ
T
FTEGR
S
Q
HE
W
I
K
Y
L
H
----
AK
TK
E
R
N
P
E
MP
D
Y
E
E
M
K
TT
GI
F
---
K
K
K
C
P
E
EHYVA
F
R
AFR
E
DP
Q
ANPLKTPSGKIEIYS
ER
LAKIA
-------
D
TWEL
K
KDE
I
I
H
PLP
A
Y
TPG
FDGWD
D
P
L
R
K
T
Y
PLQL
T
GFHYK
A
RTHS
S
YGNID
V
L
Q
Q
---
AC
P
QEVWINPIDAQ
A
RGI
RH
GD
T
VRVFN
N
N
GE
M
L
IA
AKVTPRILPGV
T
A
I
GQGAW
L
K
A
D
M
F
GD
R
V
DHGGS
I
N
I
LT
S
H
RPSP
-
LAKGNP
S
HSNLV
Q
IEK
fig|444452.5.peg.3535
Escherichia coli O157:H7 str. EC4113 (15-807/808)
ISRR
S
L
M
K
T
SA
L
GSLALA
SSA
F
T
LPF
S
QM
VR
A
A
E
APV
-
E-
-
-
EK
A
VW
S
S
C
T
VNCGSRC
L
LRLHVKD
DT
V
Y
WVE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRR
-----
R
M
NHP
----
DRL
K
YPMKRVGKRGEGKFERISWDEALDTI
SDN
L
R
RI
L
K
D
YGNEAV
H
VL
Y
G
T
G
VD
GGN
I
T
N
S
---
-
NV
-
PY
RLMN
SC
GG
F
L
SR
YGSYSTAQIS
A
AM
S
Y
MF
G
A
-----
NDGNSP
D
DI
A
N
T
KLVVMFGNNPAET
------
RMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIVIDPRY
N
DTAA
--
GREDEWLPIRPGTD
G
AL
AC
A
IAWVLI
S
EN
M
VDQPFLDKYCVGYDEKTLPA
N
AP
R
N
A
HYKAYILGEG
P
D
G
I
AKTP
E
WAA
K
IT
S
IP
AE
K
II
Q
LAREIG
S
AKPAYICQGWGPQR
H
S
NGEQT
S
RAIAML
SV
LTGNVGI
N
GGNSG
-----------
V
REG
SWDLGV
E
W
F
P
M
L
E
NPVKTQIS
V
F
T
WTDAIDHG
TE
MTA
T
R
-----
DGVR
---------
GKEKLDVPIKF
L
W
C
YA
S
NTL
I
NQH
G
DIN
H
T
N
E
V
LQD
D
SKCEMIV
G
I
D
H
FMTASAKY
C
DILLPDLM
PT
EQEDLI
SHES
AGNMGY
V
I
LA
QPATS
A
KFERKPIYW
M
LSEVAKRLGPDVYQ
T
FTEGR
S
Q
HE
W
I
K
Y
L
H
----
AK
TK
E
R
N
P
E
MP
D
Y
E
E
M
K
TT
GI
F
---
K
K
K
C
P
E
EHYVA
F
R
AFR
E
DP
Q
ANPLKTPSGKIEIYS
ER
LAKIA
-------
D
TWEL
K
KDE
I
I
H
PLP
A
Y
TPG
FDGWD
D
P
L
R
K
T
Y
PLQL
T
GFHYK
A
RTHS
S
YGNID
V
L
Q
Q
---
AC
P
QEVWINPIDAQ
A
RGI
RH
GD
T
VRVFN
N
N
GE
M
L
IA
AKVTPRILPGV
T
A
I
GQGAW
L
K
A
D
M
F
GD
R
V
DHGGS
I
N
I
LT
S
H
RPSP
-
LAKGNP
S
HSNLV
Q
IEK
fig|444450.8.peg.2338
Escherichia coli O157:H7 str. EC4115 (15-807/808)
ISRR
S
L
M
K
T
SA
L
GSLALA
SSA
F
T
LPF
S
QM
VR
A
A
E
APV
-
E-
-
-
EK
A
VW
S
S
C
T
VNCGSRC
L
LRLHVKD
DT
V
Y
WVE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRR
-----
R
M
NHP
----
DRL
K
YPMKRVGKRGEGKFERISWDEALDTI
SDN
L
R
RI
L
K
D
YGNEAV
H
VL
Y
G
T
G
VD
GGN
I
T
N
S
---
-
NV
-
PY
RLMN
SC
GG
F
L
SR
YGSYSTAQIS
A
AM
S
Y
MF
G
A
-----
NDGNSP
D
DI
A
N
T
KLVVMFGNNPAET
------
RMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIVIDPRY
N
DTAA
--
GREDEWLPIRPGTD
G
AL
AC
A
IAWVLI
S
EN
M
VDQPFLDKYCVGYDEKTLPA
N
AP
R
N
A
HYKAYILGEG
P
D
G
I
AKTP
E
WAA
K
IT
S
IP
AE
K
II
Q
LAREIG
S
AKPAYICQGWGPQR
H
S
NGEQT
S
RAIAML
SV
LTGNVGI
N
GGNSG
-----------
V
REG
SWDLGV
E
W
F
P
M
L
E
NPVKTQIS
V
F
T
WTDAIDHG
TE
MTA
T
R
-----
DGVR
---------
GKEKLDVPIKF
L
W
C
YA
S
NTL
I
NQH
G
DIN
H
T
N
E
V
LQD
D
SKCEMIV
G
I
D
H
FMTASAKY
C
DILLPDLM
PT
EQEDLI
SHES
AGNMGY
V
I
LA
QPATS
A
KFERKPIYW
M
LSEVAKRLGPDVYQ
T
FTEGR
S
Q
HE
W
I
K
Y
L
H
----
AK
TK
E
R
N
P
E
MP
D
Y
E
E
M
K
TT
GI
F
---
K
K
K
C
P
E
EHYVA
F
R
AFR
E
DP
Q
ANPLKTPSGKIEIYS
ER
LAKIA
-------
D
TWEL
K
KDE
I
I
H
PLP
A
Y
TPG
FDGWD
D
P
L
R
K
T
Y
PLQL
T
GFHYK
A
RTHS
S
YGNID
V
L
Q
Q
---
AC
P
QEVWINPIDAQ
A
RGI
RH
GD
T
VRVFN
N
N
GE
M
L
IA
AKVTPRILPGV
T
A
I
GQGAW
L
K
A
D
M
F
GD
R
V
DHGGS
I
N
I
LT
S
H
RPSP
-
LAKGNP
S
HSNLV
Q
IEK
fig|444451.5.peg.3358
Escherichia coli O157:H7 str. EC4196 (15-807/808)
ISRR
S
L
M
K
T
SA
L
GSLALA
SSA
F
T
LPF
S
QM
VR
A
A
E
APV
-
E-
-
-
EK
A
VW
S
S
C
T
VNCGSRC
L
LRLHVKD
DT
V
Y
WVE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRR
-----
R
M
NHP
----
DRL
K
YPMKRVGKRGEGKFERISWDEALDTI
SDN
L
R
RI
L
K
D
YGNEAV
H
VL
Y
G
T
G
VD
GGN
I
T
N
S
---
-
NV
-
PY
RLMN
SC
GG
F
L
SR
YGSYSTAQIS
A
AM
S
Y
MF
G
A
-----
NDGNSP
D
DI
A
N
T
KLVVMFGNNPAET
------
RMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIVIDPRY
N
DTAA
--
GREDEWLPIRPGTD
G
AL
AC
A
IAWVLI
S
EN
M
VDQPFLDKYCVGYDEKTLPA
N
AP
R
N
A
HYKAYILGEG
P
D
G
I
AKTP
E
WAA
K
IT
S
IP
AE
K
II
Q
LAREIG
S
AKPAYICQGWGPQR
H
S
NGEQT
S
RAIAML
SV
LTGNVGI
N
GGNSG
-----------
V
REG
SWDLGV
E
W
F
P
M
L
E
NPVKTQIS
V
F
T
WTDAIDHG
TE
MTA
T
R
-----
DGVR
---------
GKEKLDVPIKF
L
W
C
YA
S
NTL
I
NQH
G
DIN
H
T
N
E
V
LQD
D
SKCEMIV
G
I
D
H
FMTASAKY
C
DILLPDLM
PT
EQEDLI
SHES
AGNMGY
V
I
LA
QPATS
A
KFERKPIYW
M
LSEVAKRLGPDVYQ
T
FTEGR
S
Q
HE
W
I
K
Y
L
H
----
AK
TK
E
R
N
P
E
MP
D
Y
E
E
M
K
TT
GI
F
---
K
K
K
C
P
E
EHYVA
F
R
AFR
E
DP
Q
ANPLKTPSGKIEIYS
ER
LAKIA
-------
D
TWEL
K
KDE
I
I
H
PLP
A
Y
TPG
FDGWD
D
P
L
R
K
T
Y
PLQL
T
GFHYK
A
RTHS
S
YGNID
V
L
Q
Q
---
AC
P
QEVWINPIDAQ
A
RGI
RH
GD
T
VRVFN
N
N
GE
M
L
IA
AKVTPRILPGV
T
A
I
GQGAW
L
K
A
D
M
F
GD
R
V
DHGGS
I
N
I
LT
S
H
RPSP
-
LAKGNP
S
HSNLV
Q
IEK
fig|444447.5.peg.5163
Escherichia coli O157:H7 str. EC4206 (15-807/808)
ISRR
S
L
M
K
T
SA
L
GSLALA
SSA
F
T
LPF
S
QM
VR
A
A
E
APV
-
E-
-
-
EK
A
VW
S
S
C
T
VNCGSRC
L
LRLHVKD
DT
V
Y
WVE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRR
-----
R
M
NHP
----
DRL
K
YPMKRVGKRGEGKFERISWDEALDTI
SDN
L
R
RI
L
K
D
YGNEAV
H
VL
Y
G
T
G
VD
GGN
I
T
N
S
---
-
NV
-
PY
RLMN
SC
GG
F
L
SR
YGSYSTAQIS
A
AM
S
Y
MF
G
A
-----
NDGNSP
D
DI
A
N
T
KLVVMFGNNPAET
------
RMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIVIDPRY
N
DTAA
--
GREDEWLPIRPGTD
G
AL
AC
A
IAWVLI
S
EN
M
VDQPFLDKYCVGYDEKTLPA
N
AP
R
N
A
HYKAYILGEG
P
D
G
I
AKTP
E
WAA
K
IT
S
IP
AE
K
II
Q
LAREIG
S
AKPAYICQGWGPQR
H
S
NGEQT
S
RAIAML
SV
LTGNVGI
N
GGNSG
-----------
V
REG
SWDLGV
E
W
F
P
M
L
E
NPVKTQIS
V
F
T
WTDAIDHG
TE
MTA
T
R
-----
DGVR
---------
GKEKLDVPIKF
L
W
C
YA
S
NTL
I
NQH
G
DIN
H
T
N
E
V
LQD
D
SKCEMIV
G
I
D
H
FMTASAKY
C
DILLPDLM
PT
EQEDLI
SHES
AGNMGY
V
I
LA
QPATS
A
KFERKPIYW
M
LSEVAKRLGPDVYQ
T
FTEGR
S
Q
HE
W
I
K
Y
L
H
----
AK
TK
E
R
N
P
E
MP
D
Y
E
E
M
K
TT
GI
F
---
K
K
K
C
P
E
EHYVA
F
R
AFR
E
DP
Q
ANPLKTPSGKIEIYS
ER
LAKIA
-------
D
TWEL
K
KDE
I
I
H
PLP
A
Y
TPG
FDGWD
D
P
L
R
K
T
Y
PLQL
T
GFHYK
A
RTHS
S
YGNID
V
L
Q
Q
---
AC
P
QEVWINPIDAQ
A
RGI
RH
GD
T
VRVFN
N
N
GE
M
L
IA
AKVTPRILPGV
T
A
I
GQGAW
L
K
A
D
M
F
GD
R
V
DHGGS
I
N
I
LT
S
H
RPSP
-
LAKGNP
S
HSNLV
Q
IEK
fig|478004.5.peg.4147
Escherichia coli O157:H7 str. EC4401 (15-807/808)
ISRR
S
L
M
K
T
SA
L
GSLALA
SSA
F
T
LPF
S
QM
VR
A
A
E
APV
-
E-
-
-
EK
A
VW
S
S
C
T
VNCGSRC
L
LRLHVKD
DT
V
Y
WVE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRR
-----
R
M
NHP
----
DRL
K
YPMKRVGKRGEGKFERISWDEALDTI
SDN
L
R
RI
L
K
D
YGNEAV
H
VL
Y
G
T
G
VD
GGN
I
T
N
S
---
-
NV
-
PY
RLMN
SC
GG
F
L
SR
YGSYSTAQIS
A
AM
S
Y
MF
G
A
-----
NDGNSP
D
DI
A
N
T
KLVVMFGNNPAET
------
RMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIVIDPRY
N
DTAA
--
GREDEWLPIRPGTD
G
AL
AC
A
IAWVLI
S
EN
M
VDQPFLDKYCVGYDEKTLPA
N
AP
R
N
A
HYKAYILGEG
P
D
G
I
AKTP
E
WAA
K
IT
S
IP
AE
K
II
Q
LAREIG
S
AKPAYICQGWGPQR
H
S
NGEQT
S
RAIAML
SV
LTGNVGI
N
GGNSG
-----------
V
REG
SWDLGV
E
W
F
P
M
L
E
NPVKTQIS
V
F
T
WTDAIDHG
TE
MTA
T
R
-----
DGVR
---------
GKEKLDVPIKF
L
W
C
YA
S
NTL
I
NQH
G
DIN
H
T
N
E
V
LQD
D
SKCEMIV
G
I
D
H
FMTASAKY
C
DILLPDLM
PT
EQEDLI
SHES
AGNMGY
V
I
LA
QPATS
A
KFERKPIYW
M
LSEVAKRLGPDVYQ
T
FTEGR
S
Q
HE
W
I
K
Y
L
H
----
AK
TK
E
R
N
P
E
MP
D
Y
E
E
M
K
TT
GI
F
---
K
K
K
C
P
E
EHYVA
F
R
AFR
E
DP
Q
ANPLKTPSGKIEIYS
ER
LAKIA
-------
D
TWEL
K
KDE
I
I
H
PLP
A
Y
TPG
FDGWD
D
P
L
R
K
T
Y
PLQL
T
GFHYK
A
RTHS
S
YGNID
V
L
Q
Q
---
AC
P
QEVWINPIDAQ
A
RGI
RH
GD
T
VRVFN
N
N
GE
M
L
IA
AKVTPRILPGV
T
A
I
GQGAW
L
K
A
D
M
F
GD
R
V
DHGGS
I
N
I
LT
S
H
RPSP
-
LAKGNP
S
HSNLV
Q
IEK
fig|478005.5.peg.5248
Escherichia coli O157:H7 str. EC4486 (14-806/807)
ISRR
S
L
M
K
T
SA
L
GSLALA
SSA
F
T
LPF
S
QM
VR
A
A
E
APV
-
E-
-
-
EK
A
VW
S
S
C
T
VNCGSRC
L
LRLHVKD
DT
V
Y
WVE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRR
-----
R
M
NHP
----
DRL
K
YPMKRVGKRGEGKFERISWDEALDTI
SDN
L
R
RI
L
K
D
YGNEAV
H
VL
Y
G
T
G
VD
GGN
I
T
N
S
---
-
NV
-
PY
RLMN
SC
GG
F
L
SR
YGSYSTAQIS
A
AM
S
Y
MF
G
A
-----
NDGNSP
D
DI
A
N
T
KLVVMFGNNPAET
------
RMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIVIDPRY
N
DTAA
--
GREDEWLPIRPGTD
G
AL
AC
A
IAWVLI
S
EN
M
VDQPFLDKYCVGYDEKTLPA
N
AP
R
N
A
HYKAYILGEG
P
D
G
I
AKTP
E
WAA
K
IT
S
IP
AE
K
II
Q
LAREIG
S
AKPAYICQGWGPQR
H
S
NGEQT
S
RAIAML
SV
LTGNVGI
N
GGNSG
-----------
V
REG
SWDLGV
E
W
F
P
M
L
E
NPVKTQIS
V
F
T
WTDAIDHG
TE
MTA
T
R
-----
DGVR
---------
GKEKLDVPIKF
L
W
C
YA
S
NTL
I
NQH
G
DIN
H
T
N
E
V
LQD
D
SKCEMIV
G
I
D
H
FMTASAKY
C
DILLPDLM
PT
EQEDLI
SHES
AGNMGY
V
I
LA
QPATS
A
KFERKPIYW
M
LSEVAKRLGPDVYQ
T
FTEGR
S
Q
HE
W
I
K
Y
L
H
----
AK
TK
E
R
N
P
E
MP
D
Y
E
E
M
K
TT
GI
F
---
K
K
K
C
P
E
EHYVA
F
R
AFR
E
DP
Q
ANPLKTPSGKIEIYS
ER
LAKIA
-------
D
TWEL
K
KDE
I
I
H
PLP
A
Y
TPG
FDGWD
D
P
L
R
K
T
Y
PLQL
T
GFHYK
A
RTHS
S
YGNID
V
L
Q
Q
---
AC
P
QEVWINPIDAQ
A
RGI
RH
GD
T
VRVFN
N
N
GE
M
L
IA
AKVTPRILPGV
T
A
I
GQGAW
L
K
A
D
M
F
GD
R
V
DHGGS
I
N
I
LT
S
H
RPSP
-
LAKGNP
S
HSNLV
Q
IEK
fig|478006.5.peg.4086
Escherichia coli O157:H7 str. EC4501 (5-797/798)
ISRR
S
L
M
K
T
SA
L
GSLALA
SSA
F
T
LPF
S
QM
VR
A
A
E
APV
-
E-
-
-
EK
A
VW
S
S
C
T
VNCGSRC
L
LRLHVKD
DT
V
Y
WVE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRR
-----
R
M
NHP
----
DRL
K
YPMKRVGKRGEGKFERISWDEALDTI
SDN
L
R
RI
L
K
D
YGNEAV
H
VL
Y
G
T
G
VD
GGN
I
T
N
S
---
-
NV
-
PY
RLMN
SC
GG
F
L
SR
YGSYSTAQIS
A
AM
S
Y
MF
G
A
-----
NDGNSP
D
DI
A
N
T
KLVVMFGNNPAET
------
RMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIVIDPRY
N
DTAA
--
GREDEWLPIRPGTD
G
AL
AC
A
IAWVLI
S
EN
M
VDQPFLDKYCVGYDEKTLPA
N
AP
R
N
A
HYKAYILGEG
P
D
G
I
AKTP
E
WAA
K
IT
S
IP
AE
K
II
Q
LAREIG
S
AKPAYICQGWGPQR
H
S
NGEQT
S
RAIAML
SV
LTGNVGI
N
GGNSG
-----------
V
REG
SWDLGV
E
W
F
P
M
L
E
NPVKTQIS
V
F
T
WTDAIDHG
TE
MTA
T
R
-----
DGVR
---------
GKEKLDVPIKF
L
W
C
YA
S
NTL
I
NQH
G
DIN
H
T
N
E
V
LQD
D
SKCEMIV
G
I
D
H
FMTASAKY
C
DILLPDLM
PT
EQEDLI
SHES
AGNMGY
V
I
LA
QPATS
A
KFERKPIYW
M
LSEVAKRLGPDVYQ
T
FTEGR
S
Q
HE
W
I
K
Y
L
H
----
AK
TK
E
R
N
P
E
MP
D
Y
E
E
M
K
TT
GI
F
---
K
K
K
C
P
E
EHYVA
F
R
AFR
E
DP
Q
ANPLKTPSGKIEIYS
ER
LAKIA
-------
D
TWEL
K
KDE
I
I
H
PLP
A
Y
TPG
FDGWD
D
P
L
R
K
T
Y
PLQL
T
GFHYK
A
RTHS
S
YGNID
V
L
Q
Q
---
AC
P
QEVWINPIDAQ
A
RGI
RH
GD
T
VRVFN
N
N
GE
M
L
IA
AKVTPRILPGV
T
A
I
GQGAW
L
K
A
D
M
F
GD
R
V
DHGGS
I
N
I
LT
S
H
RPSP
-
LAKGNP
S
HSNLV
Q
IEK
fig|478007.5.peg.3502
Escherichia coli O157:H7 str. EC508 (14-806/807)
ISRR
S
L
M
K
T
SA
L
GSLALA
SSA
F
T
LPF
S
QM
VR
A
A
E
APV
-
E-
-
-
EK
A
VW
S
S
C
T
VNCGSRC
L
LRLHVKD
DT
V
Y
WVE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRR
-----
R
M
NHP
----
DRL
K
YPMKRVGKRGEGKFERISWDEALDTI
SDN
L
R
RI
L
K
D
YGNEAV
H
VL
Y
G
T
G
VD
GGN
I
T
N
S
---
-
NV
-
PY
RLMN
SC
GG
F
L
SR
YGSYSTAQIS
A
AM
S
Y
MF
G
A
-----
NDGNSP
D
DI
A
N
T
KLVVMFGNNPAET
------
RMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIVIDPRY
N
DTAA
--
GREDEWLPIRPGTD
G
AL
AC
A
IAWVLI
S
EN
M
VDQPFLDKYCVGYDEKTLPA
N
AP
R
N
A
HYKAYILGEG
P
D
G
I
AKTP
E
WAA
K
IT
S
IP
AE
K
II
Q
LAREIG
S
AKPAYICQGWGPQR
H
S
NGEQT
S
RAIAML
SV
LTGNVGI
N
GGNSG
-----------
V
REG
SWDLGV
E
W
F
P
M
L
E
NPVKTQIS
V
F
T
WTDAIDHG
TE
MTA
T
R
-----
DGVR
---------
GKEKLDVPIKF
L
W
C
YA
S
NTL
I
NQH
G
DIN
H
T
N
E
V
LQD
D
SKCEMIV
G
I
D
H
FMTASAKY
C
DILLPDLM
PT
EQEDLI
SHES
AGNMGY
V
I
LA
QPATS
A
KFERKPIYW
M
LSEVAKRLGPDVYQ
T
FTEGR
S
Q
HE
W
I
K
Y
L
H
----
AK
TK
E
R
N
P
E
MP
D
Y
E
E
M
K
TT
GI
F
---
K
K
K
C
P
E
EHYVA
F
R
AFR
E
DP
Q
ANPLKTPSGKIEIYS
ER
LAKIA
-------
D
TWEL
K
KDE
I
I
H
PLP
A
Y
TPG
FDGWD
D
P
L
R
K
T
Y
PLQL
T
GFHYK
A
RTHS
S
YGNID
V
L
Q
Q
---
AC
P
QEVWINPIDAQ
A
RGI
RH
GD
T
VRVFN
N
N
GE
M
L
IA
AKVTPRILPGV
T
A
I
GQGAW
L
K
A
D
M
F
GD
R
V
DHGGS
I
N
I
LT
S
H
RPSP
-
LAKGNP
S
HSNLV
Q
IEK
fig|478008.5.peg.4498
Escherichia coli O157:H7 str. EC869 (14-806/807)
ISRR
S
L
M
K
T
SA
L
GSLALA
SSA
F
T
LPF
S
QM
VR
A
A
E
APV
-
E-
-
-
EK
A
VW
S
S
C
T
VNCGSRC
L
LRLHVKD
DT
V
Y
WVE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRR
-----
R
M
NHP
----
DRL
K
YPMKRVGKRGEGKFERISWDEALDTI
SDN
L
R
RI
L
K
D
YGNEAV
H
VL
Y
G
T
G
VD
GGN
I
T
N
S
---
-
NV
-
PY
RLMN
SC
GG
F
L
SR
YGSYSTAQIS
A
AM
S
Y
MF
G
A
-----
NDGNSP
D
DI
A
N
T
KLVVMFGNNPAET
------
RMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIVIDPRY
N
DTAA
--
GREDEWLPIRPGTD
G
AL
AC
A
IAWVLI
S
EN
M
VDQPFLDKYCVGYDEKTLPA
N
AP
R
N
A
HYKAYILGEG
P
D
G
I
AKTP
E
WAA
K
IT
S
IP
AE
K
II
Q
LAREIG
S
AKPAYICQGWGPQR
H
S
NGEQT
S
RAIAML
SV
LTGNVGI
N
GGNSG
-----------
V
REG
SWDLGV
E
W
F
P
M
L
E
NPVKTQIS
V
F
T
WTDAIDHG
TE
MTA
T
R
-----
DGVR
---------
GKEKLDVPIKF
L
W
C
YA
S
NTL
I
NQH
G
DIN
H
T
N
E
V
LQD
D
SKCEMIV
G
I
D
H
FMTASAKY
C
DILLPDLM
PT
EQEDLI
SHES
AGNMGY
V
I
LA
QPATS
A
KFERKPIYW
M
LSEVAKRLGPDVYQ
T
FTEGR
S
Q
HE
W
I
K
Y
L
H
----
AK
TK
E
R
N
P
E
MP
D
Y
E
E
M
K
TT
GI
F
---
K
K
K
C
P
E
EHYVA
F
R
AFR
E
DP
Q
ANPLKTPSGKIEIYS
ER
LAKIA
-------
D
TWEL
K
KDE
I
I
H
PLP
A
Y
TPG
FDGWD
D
P
L
R
K
T
Y
PLQL
T
GFHYK
A
RTHS
S
YGNID
V
L
Q
Q
---
AC
P
QEVWINPIDAQ
A
RGI
RH
GD
T
VRVFN
N
N
GE
M
L
IA
AKVTPRILPGV
T
A
I
GQGAW
L
K
A
D
M
F
GD
R
V
DHGGS
I
N
I
LT
S
H
RPSP
-
LAKGNP
S
HSNLV
Q
IEK
fig|637388.3.peg.5056
Escherichia coli O157:H7 str. FRIK2000 (15-807/808)
ISRR
S
L
M
K
T
SA
L
GSLALA
SSA
F
T
LPF
S
QM
VR
A
A
E
APV
-
E-
-
-
EK
A
VW
S
S
C
T
VNCGSRC
L
LRLHVKD
DT
V
Y
WVE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRR
-----
R
M
NHP
----
DRL
K
YPMKRVGKRGEGKFERISWDEALDTI
SDN
L
R
RI
L
K
D
YGNEAV
H
VL
Y
G
T
G
VD
GGN
I
T
N
S
---
-
NV
-
PY
RLMN
SC
GG
F
L
SR
YGSYSTAQIS
A
AM
S
Y
MF
G
A
-----
NDGNSP
D
DI
A
N
T
KLVVMFGNNPAET
------
RMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIVIDPRY
N
DTAA
--
GREDEWLPIRPGTD
G
AL
AC
A
IAWVLI
S
EN
M
VDQPFLDKYCVGYDEKTLPA
N
AP
R
N
A
HYKAYILGEG
P
D
G
I
AKTP
E
WAA
K
IT
S
IP
AE
K
II
Q
LAREIG
S
AKPAYICQGWGPQR
H
S
NGEQT
S
RAIAML
SV
LTGNVGI
N
GGNSG
-----------
V
REG
SWDLGV
E
W
F
P
M
L
E
NPVKTQIS
V
F
T
WTDAIDHG
TE
MTA
T
R
-----
DGVR
---------
GKEKLDVPIKF
L
W
C
YA
S
NTL
I
NQH
G
DIN
H
T
N
E
V
LQD
D
SKCEMIV
G
I
D
H
FMTASAKY
C
DILLPDLM
PT
EQEDLI
SHES
AGNMGY
V
I
LA
QPATS
A
KFERKPIYW
M
LSEVAKRLGPDVYQ
T
FTEGR
S
Q
HE
W
I
K
Y
L
H
----
AK
TK
E
R
N
P
E
MP
D
Y
E
E
M
K
TT
GI
F
---
K
K
K
C
P
E
EHYVA
F
R
AFR
E
DP
Q
ANPLKTPSGKIEIYS
ER
LAKIA
-------
D
TWEL
K
KDE
I
I
H
PLP
A
Y
TPG
FDGWD
D
P
L
R
K
T
Y
PLQL
T
GFHYK
A
RTHS
S
YGNID
V
L
Q
Q
---
AC
P
QEVWINPIDAQ
A
RGI
RH
GD
T
VRVFN
N
N
GE
M
L
IA
AKVTPRILPGV
T
A
I
GQGAW
L
K
A
D
M
F
GD
R
V
DHGGS
I
N
I
LT
S
H
RPSP
-
LAKGNP
S
HSNLV
Q
IEK
fig|570506.3.peg.4177
Escherichia coli O157:H7 str. FRIK966 (15-807/808)
ISRR
S
L
M
K
T
SA
L
GSLALA
SSA
F
T
LPF
S
QM
VR
A
A
E
APV
-
E-
-
-
EK
A
VW
S
S
C
T
VNCGSRC
L
LRLHVKD
DT
V
Y
WVE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRR
-----
R
M
NHP
----
DRL
K
YPMKRVGKRGEGKFERISWDEALDTI
SDN
L
R
RI
L
K
D
YGNEAV
H
VL
Y
G
T
G
VD
GGN
I
T
N
S
---
-
NV
-
PY
RLMN
SC
GG
F
L
SR
YGSYSTAQIS
A
AM
S
Y
MF
G
A
-----
NDGNSP
D
DI
A
N
T
KLVVMFGNNPAET
------
RMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIVIDPRY
N
DTAA
--
GREDEWLPIRPGTD
G
AL
AC
A
IAWVLI
S
EN
M
VDQPFLDKYCVGYDEKTLPA
N
AP
R
N
A
HYKAYILGEG
P
D
G
I
AKTP
E
WAA
K
IT
S
IP
AE
K
II
Q
LAREIG
S
AKPAYICQGWGPQR
H
S
NGEQT
S
RAIAML
SV
LTGNVGI
N
GGNSG
-----------
V
REG
SWDLGV
E
W
F
P
M
L
E
NPVKTQIS
V
F
T
WTDAIDHG
TE
MTA
T
R
-----
DGVR
---------
GKEKLDVPIKF
L
W
C
YA
S
NTL
I
NQH
G
DIN
H
T
N
E
V
LQD
D
SKCEMIV
G
I
D
H
FMTASAKY
C
DILLPDLM
PT
EQEDLI
SHES
AGNMGY
V
I
LA
QPATS
A
KFERKPIYW
M
LSEVAKRLGPDVYQ
T
FTEGR
S
Q
HE
W
I
K
Y
L
H
----
AK
TK
E
R
N
P
E
MP
D
Y
E
E
M
K
TT
GI
F
---
K
K
K
C
P
E
EHYVA
F
R
AFR
E
DP
Q
ANPLKTPSGKIEIYS
ER
LAKIA
-------
D
TWEL
K
KDE
I
I
H
PLP
A
Y
TPG
FDGWD
D
P
L
R
K
T
Y
PLQL
T
GFHYK
A
RTHS
S
YGNID
V
L
Q
Q
---
AC
P
QEVWINPIDAQ
A
RGI
RH
GD
T
VRVFN
N
N
GE
M
L
IA
AKVTPRILPGV
T
A
I
GQGAW
L
K
A
D
M
F
GD
R
V
DHGGS
I
N
I
LT
S
H
RPSP
-
LAKGNP
S
HSNLV
Q
IEK
fig|386585.9.peg.2402
Escherichia coli O157:H7 str. Sakai (15-807/808)
ISRR
S
L
M
K
T
SA
L
GSLALA
SSA
F
T
LPF
S
QM
VR
A
A
E
APV
-
E-
-
-
EK
A
VW
S
S
C
T
VNCGSRC
L
LRLHVKD
DT
V
Y
WVE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRR
-----
R
M
NHP
----
DRL
K
YPMKRVGKRGEGKFERISWDEALDTI
SDN
L
R
RI
L
K
D
YGNEAV
H
VL
Y
G
T
G
VD
GGN
I
T
N
S
---
-
NV
-
PY
RLMN
SC
GG
F
L
SR
YGSYSTAQIS
A
AM
S
Y
MF
G
A
-----
NDGNSP
D
DI
A
N
T
KLVVMFGNNPAET
------
RMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIVIDPRY
N
DTAA
--
GREDEWLPIRPGTD
G
AL
AC
A
IAWVLI
S
EN
M
VDQPFLDKYCVGYDEKTLPA
N
AP
R
N
A
HYKAYILGEG
P
D
G
I
AKTP
E
WAA
K
IT
S
IP
AE
K
II
Q
LAREIG
S
AKPAYICQGWGPQR
H
S
NGEQT
S
RAIAML
SV
LTGNVGI
N
GGNSG
-----------
V
REG
SWDLGV
E
W
F
P
M
L
E
NPVKTQIS
V
F
T
WTDAIDHG
TE
MTA
T
R
-----
DGVR
---------
GKEKLDVPIKF
L
W
C
YA
S
NTL
I
NQH
G
DIN
H
T
N
E
V
LQD
D
SKCEMIV
G
I
D
H
FMTASAKY
C
DILLPDLM
PT
EQEDLI
SHES
AGNMGY
V
I
LA
QPATS
A
KFERKPIYW
M
LSEVAKRLGPDVYQ
T
FTEGR
S
Q
HE
W
I
K
Y
L
H
----
AK
TK
E
R
N
P
E
MP
D
Y
E
E
M
K
TT
GI
F
---
K
K
K
C
P
E
EHYVA
F
R
AFR
E
DP
Q
ANPLKTPSGKIEIYS
ER
LAKIA
-------
D
TWEL
K
KDE
I
I
H
PLP
A
Y
TPG
FDGWD
D
P
L
R
K
T
Y
PLQL
T
GFHYK
A
RTHS
S
YGNID
V
L
Q
Q
---
AC
P
QEVWINPIDAQ
A
RGI
RH
GD
T
VRVFN
N
N
GE
M
L
IA
AKVTPRILPGV
T
A
I
GQGAW
L
K
A
D
M
F
GD
R
V
DHGGS
I
N
I
LT
S
H
RPSP
-
LAKGNP
S
HSNLV
Q
IEK
fig|544404.4.peg.2201
Escherichia coli O157:H7 str. TW14359 (15-807/808)
ISRR
S
L
M
K
T
SA
L
GSLALA
SSA
F
T
LPF
S
QM
VR
A
A
E
APV
-
E-
-
-
EK
A
VW
S
S
C
T
VNCGSRC
L
LRLHVKD
DT
V
Y
WVE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRR
-----
R
M
NHP
----
DRL
K
YPMKRVGKRGEGKFERISWDEALDTI
SDN
L
R
RI
L
K
D
YGNEAV
H
VL
Y
G
T
G
VD
GGN
I
T
N
S
---
-
NV
-
PY
RLMN
SC
GG
F
L
SR
YGSYSTAQIS
A
AM
S
Y
MF
G
A
-----
NDGNSP
D
DI
A
N
T
KLVVMFGNNPAET
------
RMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIVIDPRY
N
DTAA
--
GREDEWLPIRPGTD
G
AL
AC
A
IAWVLI
S
EN
M
VDQPFLDKYCVGYDEKTLPA
N
AP
R
N
A
HYKAYILGEG
P
D
G
I
AKTP
E
WAA
K
IT
S
IP
AE
K
II
Q
LAREIG
S
AKPAYICQGWGPQR
H
S
NGEQT
S
RAIAML
SV
LTGNVGI
N
GGNSG
-----------
V
REG
SWDLGV
E
W
F
P
M
L
E
NPVKTQIS
V
F
T
WTDAIDHG
TE
MTA
T
R
-----
DGVR
---------
GKEKLDVPIKF
L
W
C
YA
S
NTL
I
NQH
G
DIN
H
T
N
E
V
LQD
D
SKCEMIV
G
I
D
H
FMTASAKY
C
DILLPDLM
PT
EQEDLI
SHES
AGNMGY
V
I
LA
QPATS
A
KFERKPIYW
M
LSEVAKRLGPDVYQ
T
FTEGR
S
Q
HE
W
I
K
Y
L
H
----
AK
TK
E
R
N
P
E
MP
D
Y
E
E
M
K
TT
GI
F
---
K
K
K
C
P
E
EHYVA
F
R
AFR
E
DP
Q
ANPLKTPSGKIEIYS
ER
LAKIA
-------
D
TWEL
K
KDE
I
I
H
PLP
A
Y
TPG
FDGWD
D
P
L
R
K
T
Y
PLQL
T
GFHYK
A
RTHS
S
YGNID
V
L
Q
Q
---
AC
P
QEVWINPIDAQ
A
RGI
RH
GD
T
VRVFN
N
N
GE
M
L
IA
AKVTPRILPGV
T
A
I
GQGAW
L
K
A
D
M
F
GD
R
V
DHGGS
I
N
I
LT
S
H
RPSP
-
LAKGNP
S
HSNLV
Q
IEK
fig|502346.5.peg.5111
Escherichia coli O157:H7 str. TW14588 (15-807/808)
ISRR
S
L
M
K
T
SA
L
GSLALA
SSA
F
T
LPF
S
QM
VR
A
A
E
APV
-
E-
-
-
EK
A
VW
S
S
C
T
VNCGSRC
L
LRLHVKD
DT
V
Y
WVE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRR
-----
R
M
NHP
----
DRL
K
YPMKRVGKRGEGKFERISWDEALDTI
SDN
L
R
RI
L
K
D
YGNEAV
H
VL
Y
G
T
G
VD
GGN
I
T
N
S
---
-
NV
-
PY
RLMN
SC
GG
F
L
SR
YGSYSTAQIS
A
AM
S
Y
MF
G
A
-----
NDGNSP
D
DI
A
N
T
KLVVMFGNNPAET
------
RMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIVIDPRY
N
DTAA
--
GREDEWLPIRPGTD
G
AL
AC
A
IAWVLI
S
EN
M
VDQPFLDKYCVGYDEKTLPA
N
AP
R
N
A
HYKAYILGEG
P
D
G
I
AKTP
E
WAA
K
IT
S
IP
AE
K
II
Q
LAREIG
S
AKPAYICQGWGPQR
H
S
NGEQT
S
RAIAML
SV
LTGNVGI
N
GGNSG
-----------
V
REG
SWDLGV
E
W
F
P
M
L
E
NPVKTQIS
V
F
T
WTDAIDHG
TE
MTA
T
R
-----
DGVR
---------
GKEKLDVPIKF
L
W
C
YA
S
NTL
I
NQH
G
DIN
H
T
N
E
V
LQD
D
SKCEMIV
G
I
D
H
FMTASAKY
C
DILLPDLM
PT
EQEDLI
SHES
AGNMGY
V
I
LA
QPATS
A
KFERKPIYW
M
LSEVAKRLGPDVYQ
T
FTEGR
S
Q
HE
W
I
K
Y
L
H
----
AK
TK
E
R
N
P
E
MP
D
Y
E
E
M
K
TT
GI
F
---
K
K
K
C
P
E
EHYVA
F
R
AFR
E
DP
Q
ANPLKTPSGKIEIYS
ER
LAKIA
-------
D
TWEL
K
KDE
I
I
H
PLP
A
Y
TPG
FDGWD
D
P
L
R
K
T
Y
PLQL
T
GFHYK
A
RTHS
S
YGNID
V
L
Q
Q
---
AC
P
QEVWINPIDAQ
A
RGI
RH
GD
T
VRVFN
N
N
GE
M
L
IA
AKVTPRILPGV
T
A
I
GQGAW
L
K
A
D
M
F
GD
R
V
DHGGS
I
N
I
LT
S
H
RPSP
-
LAKGNP
S
HSNLV
Q
IEK
fig|585395.4.peg.1811
Escherichia coli O103:H2 str. 12009 (15-807/808)
ISRR
S
L
M
K
T
SA
L
GSLALA
SSA
F
T
LPF
S
QM
VR
A
A
E
APV
-
E-
-
-
EK
A
VW
S
S
C
T
VNCGSRC
L
LRLHVKD
DT
V
Y
WVE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRR
-----
R
M
NHP
----
DRL
K
YPMKRVGKRGEGKFERISWDEALDTI
SDN
L
R
RI
L
K
D
YGNEAV
H
VL
Y
G
T
G
VD
GGN
I
T
N
S
---
-
NV
-
PY
RLMN
SC
GG
F
L
SR
YGSYSTAQIS
A
AM
S
Y
MF
G
A
-----
NDGNSP
D
DI
A
N
T
KLVVMFGNNPAET
------
RMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIVIDPRY
N
DTAA
--
GREDEWL
L
IRPGTD
G
AL
AC
A
IAWVLITEN
M
VDQPFLDKYCVGYDEKTLPA
N
AP
R
N
A
HYKAYILGEG
P
D
G
I
AKTP
E
WAA
K
IT
S
IP
AE
K
II
Q
LAREIG
S
AKPAYICQGWGPQR
H
S
NGEQT
S
RAIAML
SV
LTGNVGI
N
GGNSG
-----------
V
REG
SWDLGV
E
W
F
P
M
L
E
NPVKTQIS
V
F
T
WTDAIDHG
KE
MTA
T
R
-----
DGVR
---------
GKEKLDVPIKF
L
W
C
YA
S
NTL
I
NQH
G
DIN
H
THE
V
LQD
D
SKCEMIV
G
I
D
H
FMTASAKY
C
DILLPDLM
PT
EQEDLI
SHES
AGNMGY
V
I
LA
QPATS
A
KFERKPIYW
M
LSEVAKRLGPDVYQ
T
FTEGR
S
Q
HE
W
I
K
Y
L
H
----
AK
TK
E
R
N
P
E
MP
D
Y
E
E
M
K
TT
GI
F
---
K
K
K
C
P
E
EHYVA
F
R
AFR
E
DP
Q
ANPLKTPSGKIEIYS
ER
LAKIA
-------
D
TWEL
K
KDE
I
I
H
PLP
A
Y
TPG
FDGWD
D
P
L
R
K
T
Y
PLQL
T
GFHYK
A
RTHS
S
YGNID
V
L
Q
Q
---
AC
P
QEVWINPIDAQ
A
RGI
RH
GD
T
VRVFN
N
N
GE
M
L
IA
AKVTPRILPGV
T
A
I
GQGAW
L
K
A
D
M
F
GD
R
V
DHGGS
I
N
I
LT
S
H
RPSP
-
LAKGNP
S
HSNLV
Q
IEK
fig|340184.3.peg.1014
Escherichia coli B7A (15-807/808)
ISRR
S
L
M
K
T
SA
L
GSLALA
SSA
F
T
LPF
S
QM
VR
A
A
E
APV
-
E-
-
-
EK
A
VW
S
S
C
T
VNCGSRC
L
LRLHVKD
DT
V
Y
R
VE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRR
-----
R
M
NHP
----
DRL
K
YPMKRVGKRGEGKFERISWDEALDTI
SDN
L
R
RI
L
K
D
YGNEAV
H
VL
Y
G
T
G
VD
GGN
I
T
N
S
---
-
NV
-
PY
RLMN
SC
GG
F
L
SR
YGSYSTAQIS
A
AM
S
Y
MF
G
A
-----
NDGNSP
D
DI
A
N
T
KLVVMFGNNPAET
------
RMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIVIDPRY
N
DTAA
--
GREDEWLPIRPGTD
G
AL
AC
A
IAWVLITEN
M
VDQPFLDKYCVGYDEKTLPA
N
AP
R
N
A
HYKAYILGEG
P
D
G
I
AKTP
E
WAA
K
IT
S
IP
AE
K
II
Q
LAREIG
S
AKPAYICQGWGPQR
H
S
NGEQT
S
RAIAML
SV
LTGNVGI
N
GGNSG
-----------
V
REG
SWDLGV
E
W
F
P
M
L
E
NPVKTQIS
V
F
T
WTDAIDHG
TE
MTA
T
R
-----
DGVR
---------
GKEKLDVPIKF
L
W
C
YA
S
NTL
I
NQH
G
DIN
H
THE
V
LQD
D
SKCEMIV
G
I
D
H
FMTASAKY
C
DILLPDLM
PT
EQEDLI
SHES
AGNMGY
V
I
LA
QPATS
A
KFERKPIYW
M
LSEVAKRLGPDVYQ
T
FTEGR
S
Q
HE
W
V
K
Y
L
H
----
AK
TK
E
R
N
P
E
MP
D
Y
E
E
M
K
TT
GI
F
---
K
K
K
C
P
E
EHYVA
F
R
AFR
E
DP
Q
ANPLKTPSGKIEIYS
ER
LAKIA
-------
D
TWEL
K
KDE
I
I
H
PLP
A
Y
TPG
FDGWD
D
P
L
R
K
T
Y
PLQL
T
GFHYK
A
RTHS
S
YGNID
V
L
Q
Q
---
AC
P
QEVWINPIDAQ
A
RGI
RH
GD
T
VRVFN
N
N
GE
M
L
IA
AKVTPRILPGV
T
A
I
GQGAW
L
K
A
D
M
F
GD
R
V
DHGGS
I
N
I
LT
S
H
RPSP
-
LAKGNP
S
HSNLV
Q
IEK
fig|679204.3.peg.505
Escherichia coli MS 145-7 (15-807/808)
ISRR
S
L
M
K
T
SA
L
GSLALA
SSA
F
T
LPF
S
QM
VR
A
A
E
APV
-
E-
-
-
EK
A
VW
S
S
C
T
VNCGSRC
L
LRLHVKD
DT
V
Y
WVE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRR
-----
R
M
NHP
----
DRL
K
YPMKRVGKRGEGKFERISWDEALDTI
SDN
L
R
RI
L
K
D
YGNEAV
H
VL
Y
G
T
G
VD
GGN
I
T
N
S
---
-
NV
-
PY
RLMN
SC
GG
F
L
SR
YGSYSTAQIS
A
AM
S
Y
MF
G
A
-----
NDGNSP
D
DI
A
N
T
KLVVMFGNNPAET
------
RMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIVIDPRY
N
DTAA
--
GREDEWLPIRPGTD
G
AL
AC
A
IAWVLITEN
M
VDQPFLDKYCVGYDEKTLPA
N
AP
R
N
A
HYKAYILGEG
P
D
G
I
AKTP
E
WAA
K
IT
S
IP
AE
K
II
Q
LAREIG
S
AKPAYICQGWGPQR
H
S
NGEQT
S
RAIAML
SV
LTGNVGI
N
GGNSG
-----------
V
REG
SWDLGV
E
W
F
P
M
L
E
NPVKTQIS
V
F
T
WTDAIDHG
TE
MTA
T
R
-----
DGVR
---------
GKEKLDVPIKF
L
W
C
YA
S
NTL
I
NQH
G
DIN
H
THE
V
LQD
D
SKCEMIV
G
I
D
H
FMTASAKY
C
DILLPDLM
PT
EQEDLI
SHES
AGNMGY
V
I
LA
QPATS
A
KFERKPIYW
M
LSEVAKRLGPDVYQ
T
FTEGR
S
Q
HE
W
V
K
Y
L
H
----
AK
TK
E
R
N
P
E
MP
D
Y
E
E
M
K
TT
GI
F
---
K
K
K
C
P
E
EHYVA
F
R
AFR
E
DP
Q
ANPLKTPSGKIEIYS
ER
LAKIA
-------
D
TWEL
K
KDE
I
I
H
PLP
A
Y
TPG
FDGWD
D
P
L
R
K
T
Y
PLQL
T
GFHYK
A
RTHS
S
YGNID
V
L
Q
Q
---
AC
P
QEVWINPIDAQ
A
RGI
RH
GD
T
VRVFN
N
N
GE
M
L
IA
AKVTPRILPGV
T
A
I
GQGAW
L
K
A
D
M
F
GD
R
V
DHGGS
I
N
I
LT
S
H
RPSP
-
LAKGNP
S
HSNLV
Q
IEK
fig|585396.4.peg.2137
Escherichia coli O111:H- str. 11128 (15-807/808)
ISRR
S
L
M
K
T
SA
L
GSLALA
SSA
F
T
LPF
S
QM
VR
A
A
E
APV
-
E-
-
-
EK
A
VW
S
S
C
T
VNCGSRC
L
LRLHVKD
DT
V
Y
WVE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRR
-----
R
M
NHP
----
DRL
K
YPMKRVGKRGEGKFERISWDEALDTI
SDN
L
R
RI
L
K
D
YGNEAV
H
VL
Y
G
T
G
VD
GGN
I
T
N
S
---
-
NV
-
PY
RLMN
SC
GG
F
L
SR
YGSYSTAQIS
A
AM
S
Y
MF
G
A
-----
NDGNSP
D
DI
A
N
T
KLVVMFGNNPAET
------
RMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIVIDPRY
N
DTAA
--
GREDEWLPIRPGTD
G
AL
AC
A
IAWVLITEN
M
VDQPFLDKYCVGYDEKTLPA
N
AP
R
N
A
HYKAYILGEG
P
D
G
I
AKTP
E
WAA
K
IT
S
IP
AE
K
II
Q
LAREIG
S
AKPAYICQGWGPQR
H
S
NGEQT
S
RAIAML
SV
LTGNVGI
N
GGNSG
-----------
V
REG
SWDLGV
E
W
F
P
M
L
E
NPVKTQIS
V
F
T
WTDAIDHG
TE
MTA
T
R
-----
DGVR
---------
GKEKLDVPIKF
L
W
C
YA
S
NTL
I
NQH
G
DIN
H
THE
V
LQD
D
SKCEMIV
G
I
D
H
FMTASAKY
C
DILLPDLM
PT
EQEDLI
SHES
AGNMGY
V
I
LA
QPATS
A
KFERKPIYW
M
LSEVAKRLGPDVYQ
T
FTEGR
S
Q
HE
W
V
K
Y
L
H
----
AK
TK
E
R
N
P
E
MP
D
Y
E
E
M
K
TT
GI
F
---
K
K
K
C
P
E
EHYVA
F
R
AFR
E
DP
Q
ANPLKTPSGKIEIYS
ER
LAKIA
-------
D
TWEL
K
KDE
I
I
H
PLP
A
Y
TPG
FDGWD
D
P
L
R
K
T
Y
PLQL
T
GFHYK
A
RTHS
S
YGNID
V
L
Q
Q
---
AC
P
QEVWINPIDAQ
A
RGI
RH
GD
T
VRVFN
N
N
GE
M
L
IA
AKVTPRILPGV
T
A
I
GQGAW
L
K
A
D
M
F
GD
R
V
DHGGS
I
N
I
LT
S
H
RPSP
-
LAKGNP
S
HSNLV
Q
IEK
fig|573235.3.peg.2330
Escherichia coli O26:H11 str. 11368 (5-797/798)
ISRR
S
L
M
K
T
SA
L
GSLALA
SSA
F
T
LPF
S
QM
VR
A
A
E
APV
-
E-
-
-
EK
A
VW
S
S
C
T
VNCGSRC
L
LRLHVKD
DT
V
Y
WVE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRR
-----
R
M
NHP
----
DRL
K
YPMKRVGKRGEGKFERISWDEALDTI
SDN
L
R
RI
L
K
D
YGNEAV
H
VL
Y
G
T
G
VD
GGN
I
T
N
S
---
-
NV
-
PY
RLMN
SC
GG
F
L
SR
YGSYSTAQIS
A
AM
S
Y
MF
G
A
-----
NDGNSP
D
DI
A
N
T
KLVVMFGNNPAET
------
RMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIVIDPRY
N
DTAA
--
GREDEWLPIRPGTD
G
AL
AC
A
IAWVLITEN
M
VDQPFLDKYCVGYDEKTLPA
N
AP
R
N
A
HYKAYILGEG
P
D
G
I
AKTP
E
WAA
K
IT
S
IP
AE
K
II
Q
LAREIG
S
AKPAYICQGWGPQR
H
S
NGEQT
S
RAIAML
SV
LTGNVGI
N
GGNSG
-----------
V
REG
SWDLGV
E
W
F
P
M
L
E
NPVKTQIS
V
F
T
WTDAIDHG
TE
MTA
T
R
-----
DGVR
---------
GKEKLDVPIKF
L
W
C
YA
S
NTL
I
NQH
G
DIN
H
THE
V
LQD
D
SKCEMIV
G
I
D
H
FMTASAKY
C
DILLPDLM
PT
EQEDLI
SHES
AGNMGY
V
I
LA
QPATS
A
KFERKPIYW
M
LSEVAKRLGPDVYQ
T
FTEGR
S
Q
HE
W
V
K
Y
L
H
----
AK
TK
E
R
N
P
E
MP
D
Y
E
E
M
K
TT
GI
F
---
K
K
K
C
P
E
EHYVA
F
R
AFR
E
DP
Q
ANPLKTPSGKIEIYS
ER
LAKIA
-------
D
TWEL
K
KDE
I
I
H
PLP
A
Y
TPG
FDGWD
D
P
L
R
K
T
Y
PLQL
T
GFHYK
A
RTHS
S
YGNID
V
L
Q
Q
---
AC
P
QEVWINPIDAQ
A
RGI
RH
GD
T
VRVFN
N
N
GE
M
L
IA
AKVTPRILPGV
T
A
I
GQGAW
L
K
A
D
M
F
GD
R
V
DHGGS
I
N
I
LT
S
H
RPSP
-
LAKGNP
S
HSNLV
Q
IEK
fig|656393.3.peg.2376
Escherichia coli H299 (5-797/798)
ISRR
S
L
M
K
T
SA
L
GSLALA
SSA
F
T
LPF
S
QM
VR
A
A
E
APV
-
E-
-
-
EK
A
VW
S
S
C
T
VNCGSRC
L
LRLHVKD
DT
V
Y
WVE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRR
-----
R
M
NHP
----
DRL
K
YPMKRVGKRGEGKFERISWDEALD
I
I
SDN
L
R
RI
L
K
E
YGNEAV
H
VL
Y
G
T
G
VD
GGN
I
T
N
S
---
-
NV
-
PY
RLMN
SC
GG
F
L
SR
YGSYSTAQIS
A
AM
S
Y
MF
G
A
-----
NDGNSP
D
DI
A
N
T
KLVVMFGNNPAET
------
RMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIVIDPRY
N
DTAA
--
GREDEWLPIRPGTD
G
AL
AC
A
IAWVLITEN
M
VDQPFLDKYCVGYDEKTLPA
N
AP
R
N
A
HYKAYILGEG
P
D
G
I
AKTP
E
WAA
K
IT
S
IP
AE
K
II
Q
LAREIG
S
AKPAYICQGWGPQR
H
S
NGEQT
S
RAIAML
SV
LTGNVGI
N
GGNSG
-----------
V
REG
SWDLGV
E
W
F
P
M
L
E
NPVKTQIS
V
F
T
WTDAIDHG
TE
MTA
T
R
-----
DGVR
---------
GKEKLDVPIKF
L
W
C
YA
S
NTL
I
NQH
G
DIN
H
THE
V
LQD
D
SKCEMIV
G
I
D
H
FMTASAKY
C
DILLPDLM
PT
EQEDLI
SHES
AGNMGY
V
I
LA
QPATS
A
KFERKPIYW
M
LSEVAKRLGPDVYQ
T
FTEGR
S
Q
HE
W
I
K
Y
L
H
----
AK
TK
E
R
N
P
E
MP
D
Y
E
E
M
K
TT
GI
F
---
K
K
K
C
P
E
EHYVA
F
R
AFR
E
DP
Q
ANPLKTPSGKIEIYS
ER
LA
T
IA
-------
D
TWEL
K
KDE
I
I
H
PLP
A
Y
TPG
FDGWD
D
P
L
R
K
T
Y
PLQL
T
GFHYK
A
RTHS
S
YGNID
V
L
Q
Q
---
AC
P
QEVWINPIDAQ
A
RGI
RH
GD
T
VRVFN
N
N
GE
M
L
IA
AKVTPRILPGV
T
A
I
GQGAW
L
K
A
D
M
F
GD
R
V
DHGGS
I
N
I
LT
S
H
RPSP
-
LAKGNP
S
HSNLV
Q
IEK
fig|656417.3.peg.2078
Escherichia coli M605 (15-807/808)
ISRR
S
L
M
K
T
SA
L
GSLALA
SSA
F
T
LPF
S
QM
VR
A
A
Q
APV
-
E-
-
-
EK
A
VW
S
S
C
T
VNCGSRC
L
LRLHVKD
DT
V
Y
WVE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRR
-----
R
M
NHP
----
DRL
K
YPMKRVGKRGEGKFERISWDEALDTI
SDN
L
R
RI
L
K
D
YGNEAV
H
VL
Y
G
T
G
VD
GGN
I
T
N
S
---
-
NV
-
PY
RLMN
SC
GG
F
L
SR
YGSYSTAQIS
A
AM
S
Y
MF
G
A
-----
NDGNSP
D
DI
A
N
T
KLVVMFGNNPAET
------
RMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIVIDPRY
N
DTAA
--
GREDEWLPIRPGTD
G
AL
AC
A
IAWVLITEN
M
VDQPFLDKYCVGYDEKTLPA
N
AP
R
N
A
HYKAYILGEG
P
D
G
I
AKTP
E
WAA
K
IT
S
IP
AE
K
II
Q
LAREIG
S
AKPAYICQGWGPQR
H
S
NGEQT
S
RAIAML
SV
LTGNVGI
N
GGNSG
-----------
V
REG
SWDLGV
E
W
F
S
M
L
E
NPVKTQIS
V
F
T
WTDAIDHG
TE
MTA
T
R
-----
DGVR
---------
GKEKLDVPIKF
L
W
C
YA
S
NTL
I
NQH
G
DIN
H
THE
V
LQD
D
SKCEMIV
G
I
D
H
FMTASAKY
C
DILLPDLM
PT
EQEDLI
SHES
AGNMGY
V
I
LA
QPATS
A
KFERKPIYW
I
LSEVAKRLGPDVYQ
T
FTEGR
S
Q
HE
W
I
K
Y
L
H
----
AK
TK
E
R
N
P
E
MP
D
Y
E
E
M
K
TT
GI
F
---
K
K
K
C
P
E
EHYVA
F
R
AFR
E
DP
Q
ANPLKTPSGKIEIYS
ER
LA
T
IA
-------
D
TWEL
K
KDE
I
I
H
PLP
A
Y
TPG
FDGWD
D
P
L
R
G
T
Y
PLQL
T
GFHYK
A
RTHS
S
YGNID
V
L
Q
Q
---
AC
P
QEVWINPIDAQ
A
RGI
RH
GD
T
VRVFN
N
N
GE
M
L
IA
AKVTPRILPGV
T
A
I
GQGAW
L
K
A
D
M
F
GD
R
V
DHGGS
I
N
I
LT
S
H
RPSP
-
LAKGNP
S
HSNLV
Q
IEK
fig|656417.3.peg.2079
Escherichia coli M605 (14-806/807)
ISRR
S
L
M
K
T
SA
L
GSLALA
SSA
F
T
LPF
S
QM
VR
A
A
Q
APV
-
E-
-
-
EK
A
VW
S
S
C
T
VNCGSRC
L
LRLHVKD
DT
V
Y
WVE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRR
-----
R
M
NHP
----
DRL
K
YPMKRVGKRGEGKFERISWDEALDTI
SDN
L
R
RI
L
K
D
YGNEAV
H
VL
Y
G
T
G
VD
GGN
I
T
N
S
---
-
NV
-
PY
RLMN
SC
GG
F
L
SR
YGSYSTAQIS
A
AM
S
Y
MF
G
A
-----
NDGNSP
D
DI
A
N
T
KLVVMFGNNPAET
------
RMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIVIDPRY
N
DTAA
--
GREDEWLPIRPGTD
G
AL
AC
A
IAWVLITEN
M
VDQPFLDKYCVGYDEKTLPA
N
AP
R
N
A
HYKAYILGEG
P
D
G
I
AKTP
E
WAA
K
IT
S
IP
AE
K
II
Q
LAREIG
S
AKPAYICQGWGPQR
H
S
NGEQT
S
RAIAML
SV
LTGNVGI
N
GGNSG
-----------
V
REG
SWDLGV
E
W
F
S
M
L
E
NPVKTQIS
V
F
T
WTDAIDHG
TE
MTA
T
R
-----
DGVR
---------
GKEKLDVPIKF
L
W
C
YA
S
NTL
I
NQH
G
DIN
H
THE
V
LQD
D
SKCEMIV
G
I
D
H
FMTASAKY
C
DILLPDLM
PT
EQEDLI
SHES
AGNMGY
V
I
LA
QPATS
A
KFERKPIYW
I
LSEVAKRLGPDVYQ
T
FTEGR
S
Q
HE
W
I
K
Y
L
H
----
AK
TK
E
R
N
P
E
MP
D
Y
E
E
M
K
TT
GI
F
---
K
K
K
C
P
E
EHYVA
F
R
AFR
E
DP
Q
ANPLKTPSGKIEIYS
ER
LA
T
IA
-------
D
TWEL
K
KDE
I
I
H
PLP
A
Y
TPG
FDGWD
D
P
L
R
G
T
Y
PLQL
T
GFHYK
A
RTHS
S
YGNID
V
L
Q
Q
---
AC
P
QEVWINPIDAQ
A
RGI
RH
GD
T
VRVFN
N
N
GE
M
L
IA
AKVTPRILPGV
T
A
I
GQGAW
L
K
A
D
M
F
GD
R
V
DHGGS
I
N
I
LT
S
H
RPSP
-
LAKGNP
S
HSNLV
Q
IEK
fig|749548.3.peg.4735
Escherichia coli MS 196-1 (5-797/798)
ISRR
S
L
M
K
T
SA
L
GSLALA
SSA
F
T
LPF
S
QM
VR
A
A
E
APV
-
E-
-
-
EK
A
VW
S
S
C
T
VNCGSRC
L
LRLHVKD
DT
V
Y
WVE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRR
-----
R
M
NHP
----
DRL
K
YPMKRVGKRGEGKFERISWDEALDTI
SDN
L
R
RI
L
K
D
YGNEAV
H
VL
Y
G
T
G
VD
GGN
I
T
N
S
---
-
NV
-
PY
RLMN
SC
GG
F
L
SR
YGSYSTAQIS
A
AM
S
Y
MF
G
A
-----
NDGNSP
D
DI
A
N
T
KLVVMFGNNPAET
------
RMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIVIDPRY
N
DTAA
--
GREDEWLPIRPGTD
G
AL
AC
A
IAWVLITEN
M
VDQPFLDKYCVGYDEKTLPA
N
AP
R
N
A
HYKAYILGEG
P
D
G
I
AKTP
E
WAA
K
IT
S
IP
AE
K
II
Q
LAREIG
S
AKPAYICQGWGPQR
H
S
NGEQT
S
RAIAML
SV
LTGNVGI
N
GGNSG
-----------
V
REG
SWDLGV
E
W
F
P
M
L
E
NPVKTQIS
V
F
T
WTDAIDHG
TE
MTA
T
R
-----
DGVR
---------
GKEKLDVPIKF
L
W
C
YA
S
NTL
I
NQH
G
DIN
H
THE
V
LQD
D
SKCEMIV
G
I
D
H
FMTASAKY
C
DILLPDLM
PT
EQEDLI
SHES
AGNMGY
V
I
LA
QPATS
A
KFERKPIYW
M
LSEV
V
KRLGPDVYQ
T
FTEGR
S
Q
HE
W
I
K
Y
L
H
----
AK
TK
E
R
N
P
E
MP
D
Y
E
E
M
K
TT
GI
F
---
K
K
K
C
P
E
EHYVA
F
R
AFR
E
DP
Q
ANPLKTPSGKIEIYS
ER
LAKIA
-------
D
TWEL
K
KDE
I
I
H
PLP
A
Y
TPG
FDGWD
D
P
L
R
K
T
Y
PLQL
T
GFHYK
A
RTHS
S
YGNID
V
L
Q
Q
---
AC
P
QEVWINPIDAQ
A
RGI
RH
GD
T
VRVFN
N
N
GE
M
L
IA
AKVTPRILPGV
T
A
I
GQGAW
L
K
A
D
M
F
GD
R
V
DHGGS
I
N
I
LT
S
H
RPSP
-
LAKGNP
S
HSNLV
Q
IEK
fig|155864.1.peg.2331
Escherichia coli O157:H7 EDL933 (15-807/808)
ISRR
S
L
M
K
T
SA
L
GSLALA
SSA
F
T
LPF
S
QM
VR
A
A
E
APV
-
E-
-
-
EK
A
VW
S
S
C
T
VNCGSRC
L
LRLHVKD
DT
V
Y
WVE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRR
-----
R
M
NHP
----
DRL
K
YPMKRVGKRGEGKFERISWDEALDTI
SDN
L
R
RI
L
K
D
YGNEAV
H
VL
Y
G
T
G
VD
GGN
I
T
N
S
---
-
NV
-
PY
RLMN
SC
GG
F
L
SR
YGSYSTAQIS
A
AM
S
Y
MF
G
A
-----
NDGNSP
D
DI
A
N
T
KLVVMFGNNPAET
------
RMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIVIDPRY
N
DTAA
--
GREDEWLPIRPGTD
G
AL
AC
A
IAWVLI
S
EN
M
VDQPFLDKYCVGYDEKTLPA
N
AP
R
N
A
HYKAYILGEG
P
D
G
I
AKTP
E
WAA
K
IT
S
IP
AE
K
II
Q
LAREIG
S
AKPAYICQGWGPQR
H
S
NGEQT
X
RAIAML
SV
LTGNVGI
N
GGNSG
-----------
V
REG
SWDLGV
E
W
F
P
M
L
E
NPVKTQIS
V
F
T
WTDAIDHG
TE
MTA
T
R
-----
DGVR
---------
GKEKLDVPIKF
L
W
C
YA
S
NTL
I
NQH
G
DIN
H
T
N
E
V
LQD
D
SKCEMIV
G
I
D
H
FMTASAKY
C
DILLPDLM
PT
EQEDLI
SHES
AGNMGY
V
I
LA
QPATS
A
KFERKPIYW
M
LSEVAKRLGPDVYQ
T
FTEGR
S
Q
HE
W
I
K
Y
L
H
----
AK
TK
E
R
N
P
E
MP
D
Y
E
E
M
K
TT
GI
F
---
K
K
K
C
P
E
E
X
YVA
F
R
AFR
E
DP
Q
ANPLKTPSGKIEIYS
ER
LAKIA
-------
D
TWEL
K
KDE
I
I
H
PLP
A
Y
TPG
FDGWD
D
P
L
R
K
T
Y
PLQL
T
GFHYK
A
RTHS
S
YGNID
V
L
Q
Q
---
AC
P
QEVWINPIDAQ
A
RGI
RH
GD
T
VRVFN
N
N
GE
M
L
IA
AKVTPRILPGV
T
A
I
GQGAW
L
K
A
D
M
F
GD
R
V
DHGGS
I
N
I
LT
S
H
X
PSP
-
L
X
KGNP
S
HSNLV
Q
IEK
fig|155864.8.peg.2170
Escherichia coli O157:H7 EDL933 (15-807/808)
ISRR
S
L
M
K
T
SA
L
GSLALA
SSA
F
T
LPF
S
QM
VR
A
A
E
APV
-
E-
-
-
EK
A
VW
S
S
C
T
VNCGSRC
L
LRLHVKD
DT
V
Y
WVE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRR
-----
R
M
NHP
----
DRL
K
YPMKRVGKRGEGKFERISWDEALDTI
SDN
L
R
RI
L
K
D
YGNEAV
H
VL
Y
G
T
G
VD
GGN
I
T
N
S
---
-
NV
-
PY
RLMN
SC
GG
F
L
SR
YGSYSTAQIS
A
AM
S
Y
MF
G
A
-----
NDGNSP
D
DI
A
N
T
KLVVMFGNNPAET
------
RMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIVIDPRY
N
DTAA
--
GREDEWLPIRPGTD
G
AL
AC
A
IAWVLI
S
EN
M
VDQPFLDKYCVGYDEKTLPA
N
AP
R
N
A
HYKAYILGEG
P
D
G
I
AKTP
E
WAA
K
IT
S
IP
AE
K
II
Q
LAREIG
S
AKPAYICQGWGPQR
H
S
NGEQT
X
RAIAML
SV
LTGNVGI
N
GGNSG
-----------
V
REG
SWDLGV
E
W
F
P
M
L
E
NPVKTQIS
V
F
T
WTDAIDHG
TE
MTA
T
R
-----
DGVR
---------
GKEKLDVPIKF
L
W
C
YA
S
NTL
I
NQH
G
DIN
H
T
N
E
V
LQD
D
SKCEMIV
G
I
D
H
FMTASAKY
C
DILLPDLM
PT
EQEDLI
SHES
AGNMGY
V
I
LA
QPATS
A
KFERKPIYW
M
LSEVAKRLGPDVYQ
T
FTEGR
S
Q
HE
W
I
K
Y
L
H
----
AK
TK
E
R
N
P
E
MP
D
Y
E
E
M
K
TT
GI
F
---
K
K
K
C
P
E
E
X
YVA
F
R
AFR
E
DP
Q
ANPLKTPSGKIEIYS
ER
LAKIA
-------
D
TWEL
K
KDE
I
I
H
PLP
A
Y
TPG
FDGWD
D
P
L
R
K
T
Y
PLQL
T
GFHYK
A
RTHS
S
YGNID
V
L
Q
Q
---
AC
P
QEVWINPIDAQ
A
RGI
RH
GD
T
VRVFN
N
N
GE
M
L
IA
AKVTPRILPGV
T
A
I
GQGAW
L
K
A
D
M
F
GD
R
V
DHGGS
I
N
I
LT
S
H
X
PSP
-
L
X
KGNP
S
HSNLV
Q
IEK
fig|749531.3.peg.4806
Escherichia coli MS 69-1 (15-807/808)
ISRR
S
L
M
K
T
SA
L
GSLALA
SSA
F
T
LPF
S
QM
VR
A
A
E
APV
-
E-
-
-
EK
A
VW
S
S
C
T
VNCGSRC
L
LRLHVKD
DT
V
Y
WVE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRR
-----
R
M
NHP
----
DRL
K
YPMKRVGKRGEGKFERISWDEALDTI
SDN
L
R
RI
L
K
E
YGNEAV
H
VL
Y
G
T
G
VD
GGN
I
T
N
S
---
-
NV
-
PY
RLMN
SC
GG
F
L
SR
YGSYSTAQIS
A
AM
S
Y
MF
G
A
-----
NDGNSP
D
DI
A
N
T
KLVVMFGNNPAET
------
RMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIVIDPRY
N
DTAA
--
GREDEWLPIRPGTD
G
AL
AC
A
IAWVLITEN
M
VDQPFLDKYCVGYDEKTLPA
N
AP
R
N
A
HYKAYILGEG
P
D
G
I
AKTP
E
WAA
K
IT
S
IP
AE
K
II
Q
LAREIG
S
AKPAYICQGWGPQR
H
S
NGEQT
S
RAIAML
SV
LTGNVGI
N
GGNSG
-----------
V
REG
SWDLGV
E
W
F
P
M
L
E
NPVKTQIS
V
F
T
WTDAIDHG
TE
MTA
T
R
-----
DGVR
---------
GKEKLDVPIKF
L
W
C
YA
S
NTL
I
NQH
G
DIN
H
THE
V
LQD
D
SKCEMIV
G
I
D
H
FMTASAKY
C
DILLPDLM
PT
EQEDLI
SHES
AGNMGY
V
I
LA
QPATS
A
KFERKPIYW
M
LSEVAKRLGPDVYQ
T
FTEGR
S
Q
HE
W
I
K
Y
L
H
----
AK
TK
E
R
N
P
E
MP
D
Y
E
E
M
K
TT
GI
F
---
K
K
K
C
P
E
EHYVA
F
R
AFR
E
DP
Q
ANPLKTPSGKIEIYS
ER
LA
T
IA
-------
D
TWEL
K
KDE
I
I
H
PLP
A
Y
TPG
FDGWD
D
P
L
R
K
T
Y
PLQL
T
GFHYK
A
RTHS
S
YGNID
V
L
Q
Q
---
AC
P
QEVWINPIDAQ
A
RGI
RH
GD
T
VRVFN
N
N
GE
M
L
IA
AKVTPRILPGV
T
A
I
GQGAW
L
K
A
D
M
F
GD
R
V
DHGGS
I
N
I
LT
S
H
RPSP
-
LAKGNP
S
HSNLV
Q
IEK
fig|656444.3.peg.2478
Escherichia coli TA280 (15-807/808)
ISRR
S
L
M
K
T
SA
L
GSLALA
SSA
F
T
LPF
S
QM
VR
A
A
E
APV
-
E-
-
-
EK
A
VW
S
S
C
T
VNCGSRC
L
LRLHVKD
DT
V
Y
WVE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRR
-----
R
M
NHP
----
DRL
K
YPMKRVGKRGEGKFERISWDEALD
I
I
SDN
L
R
RI
L
K
E
YGNEAV
H
VL
Y
G
T
G
VD
GGN
I
T
N
S
---
-
NV
-
PY
RLMN
SC
GG
F
L
SR
YGSYSTAQIS
A
AM
S
Y
MF
G
A
-----
NDGNSP
D
DI
A
N
T
KLVVMFGNNPAET
------
RMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIVIDPRY
N
DTAA
--
GREDEWLPIRPGTD
G
AL
AC
A
IAWVLITEN
M
VDQPFLDKYCVGYDEKTLPA
N
AP
R
N
A
HYKAYILGEG
P
D
G
I
AKTP
E
WAA
K
IT
S
IP
AE
K
I
S
Q
LAREIG
S
AKPAYICQGWGPQR
H
S
NGEQT
S
RAIAML
SV
LTGNVGI
N
GGNSG
-----------
V
REG
SWDLGV
E
W
F
P
M
L
E
NPVKTQIS
V
F
T
WTDAIDHG
TE
MTA
T
R
-----
DGVR
---------
GKEKLDVPIKF
L
W
C
YA
S
NTL
I
NQH
G
DIN
H
THE
V
LQD
D
SKCEMIV
G
I
D
H
FMTASAKY
C
DILLPDLM
PT
EQEDLI
SHES
AGNMGY
V
I
LA
QPATS
A
KFERKPIYW
M
LSEVAKRLGPDVYQ
T
FTEGR
S
Q
HE
W
I
K
Y
L
H
----
AK
TK
E
R
N
P
E
MP
D
Y
E
E
M
K
TT
GI
F
---
K
K
K
C
P
E
EHYVA
F
R
AFR
E
DP
Q
ANPLKTPSGKIEIYS
ER
LA
T
IA
-------
D
TWEL
K
KDE
I
I
H
PLP
A
Y
TPG
FDGWD
D
P
L
R
K
T
Y
PLQL
T
GFHYK
A
RTHS
S
YGNID
V
L
Q
Q
---
AC
P
QEVWINPIDAQ
A
RGI
RH
GD
T
VRVFN
N
N
GE
M
L
IA
AKVTPRILPGV
T
A
I
GQGAW
L
K
A
D
M
F
GD
R
V
DHGGS
I
N
I
LT
S
H
RPSP
-
LAKGNP
S
HSNLV
Q
IEK
fig|656437.3.peg.1799
Escherichia coli TA143 (15-807/808)
ISRR
S
L
M
K
T
SA
L
GSLALA
SSA
F
T
LPF
S
QM
VR
A
A
E
APV
-
E-
-
-
EK
A
VW
S
S
C
T
VNCGSRC
L
LRLHVKD
DT
V
Y
WVE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRR
-----
R
M
NHP
----
DRL
K
YPMKRVGKRGEGKFERISWDEALDTI
SDN
L
R
RI
L
K
E
YGNEAV
H
VL
Y
G
T
G
VD
GGN
I
T
N
S
---
-
NV
-
PY
RLMN
SC
GG
F
L
SR
YGSYSTAQIS
A
AM
S
Y
MF
G
A
-----
NDGNSP
D
DI
A
N
T
KLVVMFGNNPAET
------
RMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIVIDPRY
N
DTAA
--
GREDEWLPIRPGTD
G
AL
AC
A
IAWVLITEN
M
VDQPFLDKYCVGYDEKTLPA
N
AP
R
N
A
HYKAYILGEG
P
D
G
I
AKTP
E
WAA
K
IT
S
IP
AE
K
II
H
LAREIG
S
AKPAYICQGWGPQR
H
S
NGEQT
S
RAIAML
SV
LTGNVGI
N
GGNSG
-----------
V
REG
SWDLGV
E
W
F
P
M
L
E
NPVKTQIS
V
F
T
WTDAIDHG
TE
MTA
T
R
-----
DGVR
---------
GKEKLDVPIKF
L
W
C
YA
S
NTL
I
NQH
G
DIN
H
THE
V
LQD
D
SKCEMIV
G
I
D
H
FMTASAKY
C
DILLPDLM
PT
EQEDLI
SHES
AGNMGY
V
I
LA
QPATS
A
KFERKPIYW
M
LSEVAKRLGPDVYQ
T
FTEGR
S
Q
HE
W
I
K
Y
L
H
----
AK
TK
E
R
N
P
E
MP
D
Y
E
E
M
K
TT
GI
F
---
K
K
K
C
P
E
EHYVA
F
R
AFR
E
DP
Q
ANPLKTPSGKIEIYS
ER
LA
T
IA
-------
D
TWEL
K
KDE
I
I
H
PLP
A
Y
TPG
FDGWD
D
P
L
R
K
T
Y
PLQL
T
GFHYK
A
RTHS
S
YGNID
V
L
Q
Q
---
AC
P
QEVWINPIDAQ
A
RGI
RH
GD
T
VRVFN
N
N
GE
M
L
IA
AKVTPRILPGV
T
A
I
GQGAW
L
K
A
D
M
F
GD
R
V
DHGGS
I
N
I
LT
S
H
RPSP
-
LAKGNP
S
HSNLV
Q
IEK
fig|656437.3.peg.1800
Escherichia coli TA143 (5-797/798)
ISRR
S
L
M
K
T
SA
L
GSLALA
SSA
F
T
LPF
S
QM
VR
A
A
E
APV
-
E-
-
-
EK
A
VW
S
S
C
T
VNCGSRC
L
LRLHVKD
DT
V
Y
WVE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRR
-----
R
M
NHP
----
DRL
K
YPMKRVGKRGEGKFERISWDEALDTI
SDN
L
R
RI
L
K
E
YGNEAV
H
VL
Y
G
T
G
VD
GGN
I
T
N
S
---
-
NV
-
PY
RLMN
SC
GG
F
L
SR
YGSYSTAQIS
A
AM
S
Y
MF
G
A
-----
NDGNSP
D
DI
A
N
T
KLVVMFGNNPAET
------
RMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIVIDPRY
N
DTAA
--
GREDEWLPIRPGTD
G
AL
AC
A
IAWVLITEN
M
VDQPFLDKYCVGYDEKTLPA
N
AP
R
N
A
HYKAYILGEG
P
D
G
I
AKTP
E
WAA
K
IT
S
IP
AE
K
II
H
LAREIG
S
AKPAYICQGWGPQR
H
S
NGEQT
S
RAIAML
SV
LTGNVGI
N
GGNSG
-----------
V
REG
SWDLGV
E
W
F
P
M
L
E
NPVKTQIS
V
F
T
WTDAIDHG
TE
MTA
T
R
-----
DGVR
---------
GKEKLDVPIKF
L
W
C
YA
S
NTL
I
NQH
G
DIN
H
THE
V
LQD
D
SKCEMIV
G
I
D
H
FMTASAKY
C
DILLPDLM
PT
EQEDLI
SHES
AGNMGY
V
I
LA
QPATS
A
KFERKPIYW
M
LSEVAKRLGPDVYQ
T
FTEGR
S
Q
HE
W
I
K
Y
L
H
----
AK
TK
E
R
N
P
E
MP
D
Y
E
E
M
K
TT
GI
F
---
K
K
K
C
P
E
EHYVA
F
R
AFR
E
DP
Q
ANPLKTPSGKIEIYS
ER
LA
T
IA
-------
D
TWEL
K
KDE
I
I
H
PLP
A
Y
TPG
FDGWD
D
P
L
R
K
T
Y
PLQL
T
GFHYK
A
RTHS
S
YGNID
V
L
Q
Q
---
AC
P
QEVWINPIDAQ
A
RGI
RH
GD
T
VRVFN
N
N
GE
M
L
IA
AKVTPRILPGV
T
A
I
GQGAW
L
K
A
D
M
F
GD
R
V
DHGGS
I
N
I
LT
S
H
RPSP
-
LAKGNP
S
HSNLV
Q
IEK
fig|340185.3.peg.3274
Escherichia coli E22 (15-807/808)
ISRR
S
L
M
K
T
SA
L
GSLALA
SSA
F
T
LPF
S
QM
VR
A
A
E
APV
-
E-
-
-
EK
A
VW
S
S
C
T
VNCGSRC
L
LRLHVKD
DT
V
Y
WVE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRR
-----
R
M
NHP
----
DRL
K
YPMKRVGKRGEGKFERISWDEALDTI
SDN
L
R
RI
L
K
D
YGNEAV
H
VL
Y
G
T
G
VD
GGN
I
T
N
S
---
-
NV
-
PY
RLMN
SC
GG
F
L
SR
YGSYSTAQIS
A
AM
S
Y
MF
G
A
-----
NDGNSP
D
DI
A
N
T
KLVVMFGNNPAET
------
RMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIVIDPRY
N
DTAA
--
GREDEWLPIRPGTD
G
AL
AC
A
IAWVLITEN
M
VDQPFLDKYCVGYDEKTLPA
N
AP
R
N
A
HYKAYILGEG
P
D
G
I
AKTP
E
WAA
K
IT
S
IP
AE
K
II
Q
LAREIG
S
AKPAYICQGW
R
PQR
H
S
NGEQT
S
RAIAML
SV
LTGNVGI
N
GGNSG
-----------
V
REG
SWDLGV
E
W
F
P
M
L
E
NPVKTQIS
V
F
T
WTDAIDHG
KE
MTA
T
R
-----
DGVR
---------
GKEKLDVPIKF
L
W
C
YA
S
NTL
I
NQH
G
DIN
H
THE
V
LQD
D
SKCEMIV
G
I
D
H
FMTASAKY
C
DILLPDLM
PT
EQEDLI
SHES
AGNMGY
V
I
LA
QPATS
A
KFERKPIYW
M
LSEVAKRLGPDVYQ
T
FTEGR
S
Q
HE
W
I
K
Y
L
H
----
AK
TK
E
R
N
P
E
MP
D
Y
E
E
M
K
TT
GI
F
---
K
K
K
C
P
E
EHYVA
F
R
AFR
E
DP
Q
ANPLKTPSGKIEIYS
ER
LAKIA
-------
D
TWEL
K
KDE
I
I
H
PLP
A
Y
TPG
FDGWD
D
P
L
R
K
T
Y
PLQL
T
GFHYK
A
RTHS
S
YGNID
V
L
Q
Q
---
AC
P
QEVWINPIDAQ
A
RGI
RH
GD
T
VRVFN
N
N
GE
M
L
IA
AKVTPRILPGV
T
A
I
GQGAW
L
K
A
D
M
F
GD
R
V
DHGGS
I
N
I
LT
S
H
RPSP
-
LAKGNP
S
HSNLV
Q
IEK
fig|340185.4.peg.3450
Escherichia coli E22 (5-797/798)
ISRR
S
L
M
K
T
SA
L
GSLALA
SSA
F
T
LPF
S
QM
VR
A
A
E
APV
-
E-
-
-
EK
A
VW
S
S
C
T
VNCGSRC
L
LRLHVKD
DT
V
Y
WVE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRR
-----
R
M
NHP
----
DRL
K
YPMKRVGKRGEGKFERISWDEALDTI
SDN
L
R
RI
L
K
D
YGNEAV
H
VL
Y
G
T
G
VD
GGN
I
T
N
S
---
-
NV
-
PY
RLMN
SC
GG
F
L
SR
YGSYSTAQIS
A
AM
S
Y
MF
G
A
-----
NDGNSP
D
DI
A
N
T
KLVVMFGNNPAET
------
RMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIVIDPRY
N
DTAA
--
GREDEWLPIRPGTD
G
AL
AC
A
IAWVLITEN
M
VDQPFLDKYCVGYDEKTLPA
N
AP
R
N
A
HYKAYILGEG
P
D
G
I
AKTP
E
WAA
K
IT
S
IP
AE
K
II
Q
LAREIG
S
AKPAYICQGW
R
PQR
H
S
NGEQT
S
RAIAML
SV
LTGNVGI
N
GGNSG
-----------
V
REG
SWDLGV
E
W
F
P
M
L
E
NPVKTQIS
V
F
T
WTDAIDHG
KE
MTA
T
R
-----
DGVR
---------
GKEKLDVPIKF
L
W
C
YA
S
NTL
I
NQH
G
DIN
H
THE
V
LQD
D
SKCEMIV
G
I
D
H
FMTASAKY
C
DILLPDLM
PT
EQEDLI
SHES
AGNMGY
V
I
LA
QPATS
A
KFERKPIYW
M
LSEVAKRLGPDVYQ
T
FTEGR
S
Q
HE
W
I
K
Y
L
H
----
AK
TK
E
R
N
P
E
MP
D
Y
E
E
M
K
TT
GI
F
---
K
K
K
C
P
E
EHYVA
F
R
AFR
E
DP
Q
ANPLKTPSGKIEIYS
ER
LAKIA
-------
D
TWEL
K
KDE
I
I
H
PLP
A
Y
TPG
FDGWD
D
P
L
R
K
T
Y
PLQL
T
GFHYK
A
RTHS
S
YGNID
V
L
Q
Q
---
AC
P
QEVWINPIDAQ
A
RGI
RH
GD
T
VRVFN
N
N
GE
M
L
IA
AKVTPRILPGV
T
A
I
GQGAW
L
K
A
D
M
F
GD
R
V
DHGGS
I
N
I
LT
S
H
RPSP
-
LAKGNP
S
HSNLV
Q
IEK
fig|585057.4.peg.1536
Escherichia coli IAI39 (15-807/808)
ISRR
S
L
M
K
T
SA
L
GSLALA
SSA
F
T
LPF
S
QM
VR
A
A
Q
APV
-
E-
-
-
EK
A
VW
S
S
C
T
VNCGSRC
L
LRLHVKD
DT
V
Y
WVE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRR
-----
R
M
NHP
----
DRL
K
YPMKRVGKRGEGKFERISWDEALDTI
SDN
L
R
RI
L
K
D
YGNEAV
H
VL
Y
G
T
G
VD
GGN
I
T
N
S
---
-
NV
-
PY
RLMN
SC
GG
F
L
SR
YGSYSTAQIS
A
AM
S
Y
MF
G
A
-----
NDGNSP
D
DI
A
N
T
KLVVMFGNNPAET
------
RMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIVIDPRY
N
DTAA
--
GREDEWLPIRPGTD
G
AL
AC
A
IAWVLITEN
M
VDQPFLDKYCVGYDEKTLPA
N
AP
R
N
A
HYKAYILGEG
P
D
G
I
AKTP
E
WAA
K
IT
S
IP
AE
K
II
Q
LAREIG
S
AKPAYICQGWGPQR
H
S
NGEQT
S
RAIAML
SV
LTGNVGI
N
GGNSG
-----------
V
REG
SWDLGV
E
W
F
P
M
L
E
NPVKTQIS
V
F
T
WTDAIDHG
TE
MTA
T
R
-----
DGVR
---------
GKEKLDVPIKF
L
W
C
YA
S
NTL
I
NQH
G
A
IN
H
THE
V
LQD
D
SKCEMIV
G
I
D
H
FMTASAKY
C
DILLPDLM
PT
EQEDLI
SHES
AGNMGY
V
I
LA
QPATS
A
KFERKPIYW
I
LSEVAKRLGPDVYQ
T
FTEGR
S
Q
HE
W
I
K
Y
L
H
----
AK
TK
E
R
N
P
E
MP
D
Y
E
E
M
K
TT
GI
F
---
K
K
K
C
P
E
EHYVA
F
R
AFR
E
DP
Q
ANPLKTPSGKIEIYS
ER
LA
T
IA
-------
D
TWEL
K
KDE
I
I
H
PLP
A
Y
TPG
FDGWD
D
P
L
R
K
T
Y
PLQL
T
GFHYK
A
RTHS
S
YGNID
V
L
Q
Q
---
AC
P
QEVWINPIDAQ
A
RGI
RH
GD
T
VRVFN
N
N
GE
M
L
IA
AKVTPRILPGV
T
A
I
GQGAW
L
K
A
D
M
F
GD
R
V
DHGGS
I
N
I
LT
S
H
RPSP
-
LAKGNP
S
HSNLV
Q
IEK
fig|585057.6.peg.1536
Escherichia coli IAI39 (15-807/808)
ISRR
S
L
M
K
T
SA
L
GSLALA
SSA
F
T
LPF
S
QM
VR
A
A
Q
APV
-
E-
-
-
EK
A
VW
S
S
C
T
VNCGSRC
L
LRLHVKD
DT
V
Y
WVE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRR
-----
R
M
NHP
----
DRL
K
YPMKRVGKRGEGKFERISWDEALDTI
SDN
L
R
RI
L
K
D
YGNEAV
H
VL
Y
G
T
G
VD
GGN
I
T
N
S
---
-
NV
-
PY
RLMN
SC
GG
F
L
SR
YGSYSTAQIS
A
AM
S
Y
MF
G
A
-----
NDGNSP
D
DI
A
N
T
KLVVMFGNNPAET
------
RMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIVIDPRY
N
DTAA
--
GREDEWLPIRPGTD
G
AL
AC
A
IAWVLITEN
M
VDQPFLDKYCVGYDEKTLPA
N
AP
R
N
A
HYKAYILGEG
P
D
G
I
AKTP
E
WAA
K
IT
S
IP
AE
K
II
Q
LAREIG
S
AKPAYICQGWGPQR
H
S
NGEQT
S
RAIAML
SV
LTGNVGI
N
GGNSG
-----------
V
REG
SWDLGV
E
W
F
P
M
L
E
NPVKTQIS
V
F
T
WTDAIDHG
TE
MTA
T
R
-----
DGVR
---------
GKEKLDVPIKF
L
W
C
YA
S
NTL
I
NQH
G
A
IN
H
THE
V
LQD
D
SKCEMIV
G
I
D
H
FMTASAKY
C
DILLPDLM
PT
EQEDLI
SHES
AGNMGY
V
I
LA
QPATS
A
KFERKPIYW
I
LSEVAKRLGPDVYQ
T
FTEGR
S
Q
HE
W
I
K
Y
L
H
----
AK
TK
E
R
N
P
E
MP
D
Y
E
E
M
K
TT
GI
F
---
K
K
K
C
P
E
EHYVA
F
R
AFR
E
DP
Q
ANPLKTPSGKIEIYS
ER
LA
T
IA
-------
D
TWEL
K
KDE
I
I
H
PLP
A
Y
TPG
FDGWD
D
P
L
R
K
T
Y
PLQL
T
GFHYK
A
RTHS
S
YGNID
V
L
Q
Q
---
AC
P
QEVWINPIDAQ
A
RGI
RH
GD
T
VRVFN
N
N
GE
M
L
IA
AKVTPRILPGV
T
A
I
GQGAW
L
K
A
D
M
F
GD
R
V
DHGGS
I
N
I
LT
S
H
RPSP
-
LAKGNP
S
HSNLV
Q
IEK
Consen1
Primary consensus
MTisRR
liK
saigslALa
f
lpf
--
vrtaaApv
-
a
EK
vwg
c
vncGsrcalrlhVKD
v
wve
dsTG
d
y
-
gnhqvracLrgrsirr
-----
RinHP
----
drL
yPmkrvgkRGEgkferiSWdeALdtI
l
ri
k
yGneAvf
y
aG
Ggn
t
s
a
-
RlMN
GG
l
yGsYSTaqis
aMpy
Gs
-----
ndgnsp
dieNsklVVmfGnNPaeT
------
rmsggGltY
e
arekSna
mIvIDPrysdTaa
--
GredeWlpirpGTD
AL
gIAwvLiten
vDqpFLdKYcvGYdektlpa
ap
n
hykaYilGeg
D
taKtp
WAaeITgiP
qIikLArEigaAkpayicqGWGpQRq
nGEqt
raiamL
ltGnvGi
GGnsG
-----------
Reg
e
lP
l
npvktqiS
f
wtdAiDhG
MTAir
-----
Dgvr
---------
GKekldvpIKfiW
yAgntl
nqH
DiN
the
lQd
sKcEMIVvie
fmTasAKyaDIlLPdlm
EqeDli
agNmgyii
qpats
kFErkpiywvlsevAkrLgPdvyq
fTEGr
q
Wlkfly
----
ak
aq
p
mP
yne
k
gi
---
krk
pnehyVay
aFR
DP
aNpLkTPSGKIEIYS
Lakia
-------
TWel
kde
i
Plp
y
fdgWd
p
ret
pLQL
gfHyk
RtHS
ygnidllk
---
AcrqevwInpiDAq
rGIanGD
VRVfN
rGeil
AkVTprIlpGV
avgqGAW
daem
gd
ldhgGs
N
LTa
rPSp
-
LAkgnp
hsnLV
IEKYTGNApKLTAFDqPAvQA
Consen2
Secondary consensus
lt
f
tglaag
-
-
---
qmlv
se
alp
-
--
s
k
lta
rwglmnve
i
---
s
-
-
laktipns
qstaadqvhtta
mq
mvrksy
n
lqpakg
dtyvqv
eq
kl
h
kt
e
n
ps
i
-
wr
s
v
-
l
y
s
s
d
gaaq
i
sh
avevyeqqtswt
ila
tqv
lw
m
ln
lkiawsstdeq
e
-
qlkr
gk
v
a
ir
e
ieff
dnat
iapnm
a
ht
m
qg
h
kv
e
tt
pq
-----
--
-
-
fee
lt
ks
ip
sa
s
sv
vq
-
lm
nrtmlma
i
h
y
lk
wmlvt
ml
qi
t
gf
fsyhysnggnp
vs
-
f
m
aaiagsa
-
--
e
a
d
tpvariv
alenpggkyqhn
dqtypn
ml
w
sggn
th
t
lik
w
-
-
p
gsd
yw
sa
hc
v
itt
rn
it
ys
q
-
h
v
kqvva
q
arndfd
fadl
el
k
ggke
y
k
e
iq
fhdaaqkg
e
v
l
f
a
w
nk
iemrks
kegqf
rf
d
k
a
g
eefgykdcpah
--
---
l
--
-
-
ee
k
t
d
k
q
ta
pa
l
lnya
vrq
yav
dpepit
hte
a
f
rh
w
n
q
r
v
dg
kk
c
he
l
-
-
n
ckn
c
i
sq
naca
nta
l
k
i
Consensus 1
(when a gap)
Conservative difference
Consensus 2
(when a gap)
Nonconservative diff.
Other character