fig|1040638.4.peg.3847
Escherichia coli O104:H4 str. LB226692
MT
I
KVGINGFGRIGR
I
V
F
-
R
A
A
Q
--
K
RS
D
I
E
I
VAINDL
L
DA
DY
MAY
M
LKYDS
T
HGRF
D
G
T
V
EVKD
G
H
LIV
N
GK
K
IRV
T
AER
DPA
NL
K
W
D
E
V
GVDVV
A
E
A
TG
L
F
L
T
D
E
TA
R
K
HI
T
AGAKKV
V
M
T
G
P
-
S
K
D
NTP
M
F
V
K
G
A
N
F
D
K
Y
A
G
Q
D
-
IVSNASCTTNCLAP
L
AK
V
I
N
D
N
FGI
I
E
G
L
MTT
V
HA
T
T
A
TQ
KT
VDGP
S
HKD
W
R
GG
R
G
ASQNIIP
SS
TGAAKA
V
G
K
V
L
PELNGKL
T
G
M
A
F
RVPT
P
NVSV
V
DL
T
V
R
L
E
K
A
A
T
Y
E
QIK
A
A
V
K
A
AA
E
G
EMK
G
VL
GYTE
DD
V
VS
T
DFNG
EVCT
SVFDA
KA
G
--
I
A
L
N
D
-N
F
VK
L
V
S
WYDNE
T
G
Y
S
N
KV
LDLIAHISK
fig|6666666.5357.peg.287
Escherichia coli TY-2482
MT
I
KVGINGFGRIGR
I
V
F
-
R
A
A
Q
--
K
RS
D
I
E
I
VAINDL
L
DA
DY
MAY
M
LKYDS
T
HGRF
D
G
T
V
EVKD
G
H
LIV
N
GK
K
IRV
T
AER
DPA
NL
K
W
D
E
V
GVDVV
A
E
A
TG
L
F
L
T
D
E
TA
R
K
HI
T
AGAKKV
V
M
T
G
P
-
S
K
D
NTP
M
F
V
K
G
A
N
F
D
K
Y
A
G
Q
D
-
IVSNASCTTNCLAP
L
AK
V
I
N
D
N
FGI
I
E
G
L
MTT
V
HA
T
T
A
TQ
KT
VDGP
S
HKD
W
R
GG
R
G
ASQNIIP
SS
TGAAKA
V
G
K
V
L
PELNGKL
T
G
M
A
F
RVPT
P
NVSV
V
DL
T
V
R
L
E
K
A
A
T
Y
E
QIK
A
A
V
K
A
AA
E
G
EMK
G
VL
GYTE
DD
V
VS
T
DFNG
EVCT
SVFDA
KA
G
--
I
A
L
N
D
-N
F
VK
L
V
S
WYDNE
T
G
Y
S
N
KV
LDLIAHISK
fig|216592.1.peg.1325
Escherichia coli 042 (4-334/334)
MT
I
KVGINGFGRIGR
I
V
F
-
R
A
A
Q
--
K
RS
D
I
E
I
VAINDL
L
DA
DY
MAY
M
LKYDS
T
HGRF
D
G
T
V
EVKD
G
H
LIV
N
GK
K
IRV
T
AER
DPA
NL
K
W
D
E
V
GVDVV
A
E
A
TG
L
F
L
T
D
E
TA
R
K
HI
T
AGAKKV
V
M
T
G
P
-
S
K
D
NTP
M
F
V
K
G
A
N
F
D
K
Y
A
G
Q
D
-
IVSNASCTTNCLAP
L
AK
V
I
N
D
N
FGI
I
E
G
L
MTT
V
HA
T
T
A
TQ
KT
VDGP
S
HKD
W
R
GG
R
G
ASQNIIP
SS
TGAAKA
V
G
K
V
L
PELNGKL
T
G
M
A
F
RVPT
P
NVSV
V
DL
T
V
R
L
E
K
A
A
T
Y
E
QIK
A
A
V
K
A
AA
E
G
EMK
G
VL
GYTE
DD
V
VS
T
DFNG
EVCT
SVFDA
KA
G
--
I
A
L
N
D
-N
F
VK
L
V
S
WYDNE
T
G
Y
S
N
KV
LDLIAHISK
fig|216592.3.peg.2022
Escherichia coli 042
MT
I
KVGINGFGRIGR
I
V
F
-
R
A
A
Q
--
K
RS
D
I
E
I
VAINDL
L
DA
DY
MAY
M
LKYDS
T
HGRF
D
G
T
V
EVKD
G
H
LIV
N
GK
K
IRV
T
AER
DPA
NL
K
W
D
E
V
GVDVV
A
E
A
TG
L
F
L
T
D
E
TA
R
K
HI
T
AGAKKV
V
M
T
G
P
-
S
K
D
NTP
M
F
V
K
G
A
N
F
D
K
Y
A
G
Q
D
-
IVSNASCTTNCLAP
L
AK
V
I
N
D
N
FGI
I
E
G
L
MTT
V
HA
T
T
A
TQ
KT
VDGP
S
HKD
W
R
GG
R
G
ASQNIIP
SS
TGAAKA
V
G
K
V
L
PELNGKL
T
G
M
A
F
RVPT
P
NVSV
V
DL
T
V
R
L
E
K
A
A
T
Y
E
QIK
A
A
V
K
A
AA
E
G
EMK
G
VL
GYTE
DD
V
VS
T
DFNG
EVCT
SVFDA
KA
G
--
I
A
L
N
D
-N
F
VK
L
V
S
WYDNE
T
G
Y
S
N
KV
LDLIAHISK
fig|358709.5.peg.3287
Escherichia coli 101-1
MT
I
KVGINGFGRIGR
I
V
F
-
R
A
A
Q
--
K
RS
D
I
E
I
VAINDL
L
DA
DY
MAY
M
LKYDS
T
HGRF
D
G
T
V
EVKD
G
H
LIV
N
GK
K
IRV
T
AER
DPA
NL
K
W
D
E
V
GVDVV
A
E
A
TG
L
F
L
T
D
E
TA
R
K
HI
T
AGAKKV
V
M
T
G
P
-
S
K
D
NTP
M
F
V
K
G
A
N
F
D
K
Y
A
G
Q
D
-
IVSNASCTTNCLAP
L
AK
V
I
N
D
N
FGI
I
E
G
L
MTT
V
HA
T
T
A
TQ
KT
VDGP
S
HKD
W
R
GG
R
G
ASQNIIP
SS
TGAAKA
V
G
K
V
L
PELNGKL
T
G
M
A
F
RVPT
P
NVSV
V
DL
T
V
R
L
E
K
A
A
T
Y
E
QIK
A
A
V
K
A
AA
E
G
EMK
G
VL
GYTE
DD
V
VS
T
DFNG
EVCT
SVFDA
KA
G
--
I
A
L
N
D
-N
F
VK
L
V
S
WYDNE
T
G
Y
S
N
KV
LDLIAHISK
fig|562.371.peg.4643
Escherichia coli 1044A
MT
I
KVGINGFGRIGR
I
V
F
-
R
A
A
Q
--
K
RS
D
I
E
I
VAINDL
L
DA
DY
MAY
M
LKYDS
T
HGRF
D
G
T
V
EVKD
G
H
LIV
N
GK
K
IRV
T
AER
DPA
NL
K
W
D
E
V
GVDVV
A
E
A
TG
L
F
L
T
D
E
TA
R
K
HI
T
AGAKKV
V
M
T
G
P
-
S
K
D
NTP
M
F
V
K
G
A
N
F
D
K
Y
A
G
Q
D
-
IVSNASCTTNCLAP
L
AK
V
I
N
D
N
FGI
I
E
G
L
MTT
V
HA
T
T
A
TQ
KT
VDGP
S
HKD
W
R
GG
R
G
ASQNIIP
SS
TGAAKA
V
G
K
V
L
PELNGKL
T
G
M
A
F
RVPT
P
NVSV
V
DL
T
V
R
L
E
K
A
A
T
Y
E
QIK
A
A
V
K
A
AA
E
G
EMK
G
VL
GYTE
DD
V
VS
T
DFNG
EVCT
SVFDA
KA
G
--
I
A
L
N
D
-N
F
VK
L
V
S
WYDNE
T
G
Y
S
N
KV
LDLIAHISK
fig|562.373.peg.5543
Escherichia coli 1125A
MT
I
KVGINGFGRIGR
I
V
F
-
R
A
A
Q
--
K
RS
D
I
E
I
VAINDL
L
DA
DY
MAY
M
LKYDS
T
HGRF
D
G
T
V
EVKD
G
H
LIV
N
GK
K
IRV
T
AER
DPA
NL
K
W
D
E
V
GVDVV
A
E
A
TG
L
F
L
T
D
E
TA
R
K
HI
T
AGAKKV
V
M
T
G
P
-
S
K
D
NTP
M
F
V
K
G
A
N
F
D
K
Y
A
G
Q
D
-
IVSNASCTTNCLAP
L
AK
V
I
N
D
N
FGI
I
E
G
L
MTT
V
HA
T
T
A
TQ
KT
VDGP
S
HKD
W
R
GG
R
G
ASQNIIP
SS
TGAAKA
V
G
K
V
L
PELNGKL
T
G
M
A
F
RVPT
P
NVSV
V
DL
T
V
R
L
E
K
A
A
T
Y
E
QIK
A
A
V
K
A
AA
E
G
EMK
G
VL
GYTE
DD
V
VS
T
DFNG
EVCT
SVFDA
KA
G
--
I
A
L
N
D
-N
F
VK
L
V
S
WYDNE
T
G
Y
S
N
KV
LDLIAHISK
fig|562.372.peg.4875
Escherichia coli 1212A
MT
I
KVGINGFGRIGR
I
V
F
-
R
A
A
Q
--
K
RS
D
I
E
I
VAINDL
L
DA
DY
MAY
M
LKYDS
T
HGRF
D
G
T
V
EVKD
G
H
LIV
N
GK
K
IRV
T
AER
DPA
NL
K
W
D
E
V
GVDVV
A
E
A
TG
L
F
L
T
D
E
TA
R
K
HI
T
AGAKKV
V
M
T
G
P
-
S
K
D
NTP
M
F
V
K
G
A
N
F
D
K
Y
A
G
Q
D
-
IVSNASCTTNCLAP
L
AK
V
I
N
D
N
FGI
I
E
G
L
MTT
V
HA
T
T
A
TQ
KT
VDGP
S
HKD
W
R
GG
R
G
ASQNIIP
SS
TGAAKA
V
G
K
V
L
PELNGKL
T
G
M
A
F
RVPT
P
NVSV
V
DL
T
V
R
L
E
K
A
A
T
Y
E
QIK
A
A
V
K
A
AA
E
G
EMK
G
VL
GYTE
DD
V
VS
T
DFNG
EVCT
SVFDA
KA
G
--
I
A
L
N
D
-N
F
VK
L
V
S
WYDNE
T
G
Y
S
N
KV
LDLIAHISK
fig|670897.3.peg.2662
Escherichia coli 2362-75
MT
I
KVGINGFGRIGR
I
V
F
-
R
A
A
Q
--
K
RS
D
I
E
I
VAINDL
L
DA
DY
MAY
M
LKYDS
T
HGRF
D
G
T
V
EVKD
G
H
LIV
N
GK
K
IRV
T
AER
DPA
NL
K
W
D
E
V
GVDVV
A
E
A
TG
L
F
L
T
D
E
TA
R
K
HI
T
AGAKKV
V
M
T
G
P
-
S
K
D
NTP
M
F
V
K
G
A
N
F
D
K
Y
A
G
Q
D
-
IVSNASCTTNCLAP
L
AK
V
I
N
D
N
FGI
I
E
G
L
MTT
V
HA
T
T
A
TQ
KT
VDGP
S
HKD
W
R
GG
R
G
ASQNIIP
SS
TGAAKA
V
G
K
V
L
PELNGKL
T
G
M
A
F
RVPT
P
NVSV
V
DL
T
V
R
L
E
K
A
A
T
Y
E
QIK
A
A
V
K
A
AA
E
G
EMK
G
VL
GYTE
DD
V
VS
T
DFNG
EVCT
SVFDA
KA
G
--
I
A
L
N
D
-N
F
VK
L
V
S
WYDNE
T
G
Y
S
N
KV
LDLIAHISK
fig|362663.8.peg.1748
Escherichia coli 536
MT
I
KVGINGFGRIGR
I
V
F
-
R
A
A
Q
--
K
RS
D
I
E
I
VAINDL
L
DA
DY
MAY
M
LKYDS
T
HGRF
D
G
T
V
EVKD
G
H
LIV
N
GK
K
IRV
T
AER
DPA
NL
K
W
D
E
V
GVDVV
A
E
A
TG
L
F
L
T
D
E
TA
R
K
HI
T
AGAKKV
V
M
T
G
P
-
S
K
D
NTP
M
F
V
K
G
A
N
F
D
K
Y
A
G
Q
D
-
IVSNASCTTNCLAP
L
AK
V
I
N
D
N
FGI
I
E
G
L
MTT
V
HA
T
T
A
TQ
KT
VDGP
S
HKD
W
R
GG
R
G
ASQNIIP
SS
TGAAKA
V
G
K
V
L
PELNGKL
T
G
M
A
F
RVPT
P
NVSV
V
DL
T
V
R
L
E
K
A
A
T
Y
E
QIK
A
A
V
K
A
AA
E
G
EMK
G
VL
GYTE
DD
V
VS
T
DFNG
EVCT
SVFDA
KA
G
--
I
A
L
N
D
-N
F
VK
L
V
S
WYDNE
T
G
Y
S
N
KV
LDLIAHISK
fig|362663.9.peg.1752
Escherichia coli 536
MT
I
KVGINGFGRIGR
I
V
F
-
R
A
A
Q
--
K
RS
D
I
E
I
VAINDL
L
DA
DY
MAY
M
LKYDS
T
HGRF
D
G
T
V
EVKD
G
H
LIV
N
GK
K
IRV
T
AER
DPA
NL
K
W
D
E
V
GVDVV
A
E
A
TG
L
F
L
T
D
E
TA
R
K
HI
T
AGAKKV
V
M
T
G
P
-
S
K
D
NTP
M
F
V
K
G
A
N
F
D
K
Y
A
G
Q
D
-
IVSNASCTTNCLAP
L
AK
V
I
N
D
N
FGI
I
E
G
L
MTT
V
HA
T
T
A
TQ
KT
VDGP
S
HKD
W
R
GG
R
G
ASQNIIP
SS
TGAAKA
V
G
K
V
L
PELNGKL
T
G
M
A
F
RVPT
P
NVSV
V
DL
T
V
R
L
E
K
A
A
T
Y
E
QIK
A
A
V
K
A
AA
E
G
EMK
G
VL
GYTE
DD
V
VS
T
DFNG
EVCT
SVFDA
KA
G
--
I
A
L
N
D
-N
F
VK
L
V
S
WYDNE
T
G
Y
S
N
KV
LDLIAHISK
fig|344610.3.peg.2360
Escherichia coli 53638
MT
I
KVGINGFGRIGR
I
V
F
-
R
A
A
Q
--
K
RS
D
I
E
I
VAINDL
L
DA
DY
MAY
M
LKYDS
T
HGRF
D
G
T
V
EVKD
G
H
LIV
N
GK
K
IRV
T
AER
DPA
NL
K
W
D
E
V
GVDVV
A
E
A
TG
L
F
L
T
D
E
TA
R
K
HI
T
AGAKKV
V
M
T
G
P
-
S
K
D
NTP
M
F
V
K
G
A
N
F
D
K
Y
A
G
Q
D
-
IVSNASCTTNCLAP
L
AK
V
I
N
D
N
FGI
I
E
G
L
MTT
V
HA
T
T
A
TQ
KT
VDGP
S
HKD
W
R
GG
R
G
ASQNIIP
SS
TGAAKA
V
G
K
V
L
PELNGKL
T
G
M
A
F
RVPT
P
NVSV
V
DL
T
V
R
L
E
K
A
A
T
Y
E
QIK
A
A
V
K
A
AA
E
G
EMK
G
VL
GYTE
DD
V
VS
T
DFNG
EVCT
SVFDA
KA
G
--
I
A
L
N
D
-N
F
VK
L
V
S
WYDNE
T
G
Y
S
N
KV
LDLIAHISK
fig|344610.7.peg.5439
Escherichia coli 53638
MT
I
KVGINGFGRIGR
I
V
F
-
R
A
A
Q
--
K
RS
D
I
E
I
VAINDL
L
DA
DY
MAY
M
LKYDS
T
HGRF
D
G
T
V
EVKD
G
H
LIV
N
GK
K
IRV
T
AER
DPA
NL
K
W
D
E
V
GVDVV
A
E
A
TG
L
F
L
T
D
E
TA
R
K
HI
T
AGAKKV
V
M
T
G
P
-
S
K
D
NTP
M
F
V
K
G
A
N
F
D
K
Y
A
G
Q
D
-
IVSNASCTTNCLAP
L
AK
V
I
N
D
N
FGI
I
E
G
L
MTT
V
HA
T
T
A
TQ
KT
VDGP
S
HKD
W
R
GG
R
G
ASQNIIP
SS
TGAAKA
V
G
K
V
L
PELNGKL
T
G
M
A
F
RVPT
P
NVSV
V
DL
T
V
R
L
E
K
A
A
T
Y
E
QIK
A
A
V
K
A
AA
E
G
EMK
G
VL
GYTE
DD
V
VS
T
DFNG
EVCT
SVFDA
KA
G
--
I
A
L
N
D
-N
F
VK
L
V
S
WYDNE
T
G
Y
S
N
KV
LDLIAHISK
fig|562.374.peg.4237
Escherichia coli 536A
MT
I
KVGINGFGRIGR
I
V
F
-
R
A
A
Q
--
K
RS
D
I
E
I
VAINDL
L
DA
DY
MAY
M
LKYDS
T
HGRF
D
G
T
V
EVKD
G
H
LIV
N
GK
K
IRV
T
AER
DPA
NL
K
W
D
E
V
GVDVV
A
E
A
TG
L
F
L
T
D
E
TA
R
K
HI
T
AGAKKV
V
M
T
G
P
-
S
K
D
NTP
M
F
V
K
G
A
N
F
D
K
Y
A
G
Q
D
-
IVSNASCTTNCLAP
L
AK
V
I
N
D
N
FGI
I
E
G
L
MTT
V
HA
T
T
A
TQ
KT
VDGP
S
HKD
W
R
GG
R
G
ASQNIIP
SS
TGAAKA
V
G
K
V
L
PELNGKL
T
G
M
A
F
RVPT
P
NVSV
V
DL
T
V
R
L
E
K
A
A
T
Y
E
QIK
A
A
V
K
A
AA
E
G
EMK
G
VL
GYTE
DD
V
VS
T
DFNG
EVCT
SVFDA
KA
G
--
I
A
L
N
D
-N
F
VK
L
V
S
WYDNE
T
G
Y
S
N
KV
LDLIAHISK
fig|585055.6.peg.1978
Escherichia coli 55989
MT
I
KVGINGFGRIGR
I
V
F
-
R
A
A
Q
--
K
RS
D
I
E
I
VAINDL
L
DA
DY
MAY
M
LKYDS
T
HGRF
D
G
T
V
EVKD
G
H
LIV
N
GK
K
IRV
T
AER
DPA
NL
K
W
D
E
V
GVDVV
A
E
A
TG
L
F
L
T
D
E
TA
R
K
HI
T
AGAKKV
V
M
T
G
P
-
S
K
D
NTP
M
F
V
K
G
A
N
F
D
K
Y
A
G
Q
D
-
IVSNASCTTNCLAP
L
AK
V
I
N
D
N
FGI
I
E
G
L
MTT
V
HA
T
T
A
TQ
KT
VDGP
S
HKD
W
R
GG
R
G
ASQNIIP
SS
TGAAKA
V
G
K
V
L
PELNGKL
T
G
M
A
F
RVPT
P
NVSV
V
DL
T
V
R
L
E
K
A
A
T
Y
E
QIK
A
A
V
K
A
AA
E
G
EMK
G
VL
GYTE
DD
V
VS
T
DFNG
EVCT
SVFDA
KA
G
--
I
A
L
N
D
-N
F
VK
L
V
S
WYDNE
T
G
Y
S
N
KV
LDLIAHISK
fig|585055.8.peg.1981
Escherichia coli 55989
MT
I
KVGINGFGRIGR
I
V
F
-
R
A
A
Q
--
K
RS
D
I
E
I
VAINDL
L
DA
DY
MAY
M
LKYDS
T
HGRF
D
G
T
V
EVKD
G
H
LIV
N
GK
K
IRV
T
AER
DPA
NL
K
W
D
E
V
GVDVV
A
E
A
TG
L
F
L
T
D
E
TA
R
K
HI
T
AGAKKV
V
M
T
G
P
-
S
K
D
NTP
M
F
V
K
G
A
N
F
D
K
Y
A
G
Q
D
-
IVSNASCTTNCLAP
L
AK
V
I
N
D
N
FGI
I
E
G
L
MTT
V
HA
T
T
A
TQ
KT
VDGP
S
HKD
W
R
GG
R
G
ASQNIIP
SS
TGAAKA
V
G
K
V
L
PELNGKL
T
G
M
A
F
RVPT
P
NVSV
V
DL
T
V
R
L
E
K
A
A
T
Y
E
QIK
A
A
V
K
A
AA
E
G
EMK
G
VL
GYTE
DD
V
VS
T
DFNG
EVCT
SVFDA
KA
G
--
I
A
L
N
D
-N
F
VK
L
V
S
WYDNE
T
G
Y
S
N
KV
LDLIAHISK
fig|525281.3.peg.719
Escherichia coli 83972
MT
I
KVGINGFGRIGR
I
V
F
-
R
A
A
Q
--
K
RS
D
I
E
I
VAINDL
L
DA
DY
MAY
M
LKYDS
T
HGRF
D
G
T
V
EVKD
G
H
LIV
N
GK
K
IRV
T
AER
DPA
NL
K
W
D
E
V
GVDVV
A
E
A
TG
L
F
L
T
D
E
TA
R
K
HI
T
AGAKKV
V
M
T
G
P
-
S
K
D
NTP
M
F
V
K
G
A
N
F
D
K
Y
A
G
Q
D
-
IVSNASCTTNCLAP
L
AK
V
I
N
D
N
FGI
I
E
G
L
MTT
V
HA
T
T
A
TQ
KT
VDGP
S
HKD
W
R
GG
R
G
ASQNIIP
SS
TGAAKA
V
G
K
V
L
PELNGKL
T
G
M
A
F
RVPT
P
NVSV
V
DL
T
V
R
L
E
K
A
A
T
Y
E
QIK
A
A
V
K
A
AA
E
G
EMK
G
VL
GYTE
DD
V
VS
T
DFNG
EVCT
SVFDA
KA
G
--
I
A
L
N
D
-N
F
VK
L
V
S
WYDNE
T
G
Y
S
N
KV
LDLIAHISK
fig|655817.3.peg.2133
Escherichia coli ABU 83972
MT
I
KVGINGFGRIGR
I
V
F
-
R
A
A
Q
--
K
RS
D
I
E
I
VAINDL
L
DA
DY
MAY
M
LKYDS
T
HGRF
D
G
T
V
EVKD
G
H
LIV
N
GK
K
IRV
T
AER
DPA
NL
K
W
D
E
V
GVDVV
A
E
A
TG
L
F
L
T
D
E
TA
R
K
HI
T
AGAKKV
V
M
T
G
P
-
S
K
D
NTP
M
F
V
K
G
A
N
F
D
K
Y
A
G
Q
D
-
IVSNASCTTNCLAP
L
AK
V
I
N
D
N
FGI
I
E
G
L
MTT
V
HA
T
T
A
TQ
KT
VDGP
S
HKD
W
R
GG
R
G
ASQNIIP
SS
TGAAKA
V
G
K
V
L
PELNGKL
T
G
M
A
F
RVPT
P
NVSV
V
DL
T
V
R
L
E
K
A
A
T
Y
E
QIK
A
A
V
K
A
AA
E
G
EMK
G
VL
GYTE
DD
V
VS
T
DFNG
EVCT
SVFDA
KA
G
--
I
A
L
N
D
-N
F
VK
L
V
S
WYDNE
T
G
Y
S
N
KV
LDLIAHISK
fig|405955.13.peg.1871
Escherichia coli APEC O1
MT
I
KVGINGFGRIGR
I
V
F
-
R
A
A
Q
--
K
RS
D
I
E
I
VAINDL
L
DA
DY
MAY
M
LKYDS
T
HGRF
D
G
T
V
EVKD
G
H
LIV
N
GK
K
IRV
T
AER
DPA
NL
K
W
D
E
V
GVDVV
A
E
A
TG
L
F
L
T
D
E
TA
R
K
HI
T
AGAKKV
V
M
T
G
P
-
S
K
D
NTP
M
F
V
K
G
A
N
F
D
K
Y
A
G
Q
D
-
IVSNASCTTNCLAP
L
AK
V
I
N
D
N
FGI
I
E
G
L
MTT
V
HA
T
T
A
TQ
KT
VDGP
S
HKD
W
R
GG
R
G
ASQNIIP
SS
TGAAKA
V
G
K
V
L
PELNGKL
T
G
M
A
F
RVPT
P
NVSV
V
DL
T
V
R
L
E
K
A
A
T
Y
E
QIK
A
A
V
K
A
AA
E
G
EMK
G
VL
GYTE
DD
V
VS
T
DFNG
EVCT
SVFDA
KA
G
--
I
A
L
N
D
-N
F
VK
L
V
S
WYDNE
T
G
Y
S
N
KV
LDLIAHISK
fig|405955.9.peg.1530
Escherichia coli APEC O1 (4-334/334)
MT
I
KVGINGFGRIGR
I
V
F
-
R
A
A
Q
--
K
RS
D
I
E
I
VAINDL
L
DA
DY
MAY
M
LKYDS
T
HGRF
D
G
T
V
EVKD
G
H
LIV
N
GK
K
IRV
T
AER
DPA
NL
K
W
D
E
V
GVDVV
A
E
A
TG
L
F
L
T
D
E
TA
R
K
HI
T
AGAKKV
V
M
T
G
P
-
S
K
D
NTP
M
F
V
K
G
A
N
F
D
K
Y
A
G
Q
D
-
IVSNASCTTNCLAP
L
AK
V
I
N
D
N
FGI
I
E
G
L
MTT
V
HA
T
T
A
TQ
KT
VDGP
S
HKD
W
R
GG
R
G
ASQNIIP
SS
TGAAKA
V
G
K
V
L
PELNGKL
T
G
M
A
F
RVPT
P
NVSV
V
DL
T
V
R
L
E
K
A
A
T
Y
E
QIK
A
A
V
K
A
AA
E
G
EMK
G
VL
GYTE
DD
V
VS
T
DFNG
EVCT
SVFDA
KA
G
--
I
A
L
N
D
-N
F
VK
L
V
S
WYDNE
T
G
Y
S
N
KV
LDLIAHISK
fig|481805.3.peg.1999
Escherichia coli ATCC 8739 (4-334/334)
MT
I
KVGINGFGRIGR
I
V
F
-
R
A
A
Q
--
K
RS
D
I
E
I
VAINDL
L
DA
DY
MAY
M
LKYDS
T
HGRF
D
G
T
V
EVKD
G
H
LIV
N
GK
K
IRV
T
AER
DPA
NL
K
W
D
E
V
GVDVV
A
E
A
TG
L
F
L
T
D
E
TA
R
K
HI
T
AGAKKV
V
M
T
G
P
-
S
K
D
NTP
M
F
V
K
G
A
N
F
D
K
Y
A
G
Q
D
-
IVSNASCTTNCLAP
L
AK
V
I
N
D
N
FGI
I
E
G
L
MTT
V
HA
T
T
A
TQ
KT
VDGP
S
HKD
W
R
GG
R
G
ASQNIIP
SS
TGAAKA
V
G
K
V
L
PELNGKL
T
G
M
A
F
RVPT
P
NVSV
V
DL
T
V
R
L
E
K
A
A
T
Y
E
QIK
A
A
V
K
A
AA
E
G
EMK
G
VL
GYTE
DD
V
VS
T
DFNG
EVCT
SVFDA
KA
G
--
I
A
L
N
D
-N
F
VK
L
V
S
WYDNE
T
G
Y
S
N
KV
LDLIAHISK
fig|481805.6.peg.1993
Escherichia coli ATCC 8739
MT
I
KVGINGFGRIGR
I
V
F
-
R
A
A
Q
--
K
RS
D
I
E
I
VAINDL
L
DA
DY
MAY
M
LKYDS
T
HGRF
D
G
T
V
EVKD
G
H
LIV
N
GK
K
IRV
T
AER
DPA
NL
K
W
D
E
V
GVDVV
A
E
A
TG
L
F
L
T
D
E
TA
R
K
HI
T
AGAKKV
V
M
T
G
P
-
S
K
D
NTP
M
F
V
K
G
A
N
F
D
K
Y
A
G
Q
D
-
IVSNASCTTNCLAP
L
AK
V
I
N
D
N
FGI
I
E
G
L
MTT
V
HA
T
T
A
TQ
KT
VDGP
S
HKD
W
R
GG
R
G
ASQNIIP
SS
TGAAKA
V
G
K
V
L
PELNGKL
T
G
M
A
F
RVPT
P
NVSV
V
DL
T
V
R
L
E
K
A
A
T
Y
E
QIK
A
A
V
K
A
AA
E
G
EMK
G
VL
GYTE
DD
V
VS
T
DFNG
EVCT
SVFDA
KA
G
--
I
A
L
N
D
-N
F
VK
L
V
S
WYDNE
T
G
Y
S
N
KV
LDLIAHISK
fig|413997.3.peg.1829
Escherichia coli B str. REL606
MT
I
KVGINGFGRIGR
I
V
F
-
R
A
A
Q
--
K
RS
D
I
E
I
VAINDL
L
DA
DY
MAY
M
LKYDS
T
HGRF
D
G
T
V
EVKD
G
H
LIV
N
GK
K
IRV
T
AER
DPA
NL
K
W
D
E
V
GVDVV
A
E
A
TG
L
F
L
T
D
E
TA
R
K
HI
T
AGAKKV
V
M
T
G
P
-
S
K
D
NTP
M
F
V
K
G
A
N
F
D
K
Y
A
G
Q
D
-
IVSNASCTTNCLAP
L
AK
V
I
N
D
N
FGI
I
E
G
L
MTT
V
HA
T
T
A
TQ
KT
VDGP
S
HKD
W
R
GG
R
G
ASQNIIP
SS
TGAAKA
V
G
K
V
L
PELNGKL
T
G
M
A
F
RVPT
P
NVSV
V
DL
T
V
R
L
E
K
A
A
T
Y
E
QIK
A
A
V
K
A
AA
E
G
EMK
G
VL
GYTE
DD
V
VS
T
DFNG
EVCT
SVFDA
KA
G
--
I
A
L
N
D
-N
F
VK
L
V
S
WYDNE
T
G
Y
S
N
KV
LDLIAHISK
fig|550672.3.peg.2632
Escherichia coli B088
MT
I
KVGINGFGRIGR
I
V
F
-
R
A
A
Q
--
K
RS
D
I
E
I
VAINDL
L
DA
DY
MAY
M
LKYDS
T
HGRF
D
G
T
V
EVKD
G
H
LIV
N
GK
K
IRV
T
AER
DPA
NL
K
W
D
E
V
GVDVV
A
E
A
TG
L
F
L
T
D
E
TA
R
K
HI
T
AGAKKV
V
M
T
G
P
-
S
K
D
NTP
M
F
V
K
G
A
N
F
D
K
Y
A
G
Q
D
-
IVSNASCTTNCLAP
L
AK
V
I
N
D
N
FGI
I
E
G
L
MTT
V
HA
T
T
A
TQ
KT
VDGP
S
HKD
W
R
GG
R
G
ASQNIIP
SS
TGAAKA
V
G
K
V
L
PELNGKL
T
G
M
A
F
RVPT
P
NVSV
V
DL
T
V
R
L
E
K
A
A
T
Y
E
QIK
A
A
V
K
A
AA
E
G
EMK
G
VL
GYTE
DD
V
VS
T
DFNG
EVCT
SVFDA
KA
G
--
I
A
L
N
D
-N
F
VK
L
V
S
WYDNE
T
G
Y
S
N
KV
LDLIAHISK
fig|344601.3.peg.2892
Escherichia coli B171
MT
I
KVGINGFGRIGR
I
V
F
-
R
A
A
Q
--
K
RS
D
I
E
I
VAINDL
L
DA
DY
MAY
M
LKYDS
T
HGRF
D
G
T
V
EVKD
G
H
LIV
N
GK
K
IRV
T
AER
DPA
NL
K
W
D
E
V
GVDVV
A
E
A
TG
L
F
L
T
D
E
TA
R
K
HI
T
AGAKKV
V
M
T
G
P
-
S
K
D
NTP
M
F
V
K
G
A
N
F
D
K
Y
A
G
Q
D
-
IVSNASCTTNCLAP
L
AK
V
I
N
D
N
FGI
I
E
G
L
MTT
V
HA
T
T
A
TQ
KT
VDGP
S
HKD
W
R
GG
R
G
ASQNIIP
SS
TGAAKA
V
G
K
V
L
PELNGKL
T
G
M
A
F
RVPT
P
NVSV
V
DL
T
V
R
L
E
K
A
A
T
Y
E
QIK
A
A
V
K
A
AA
E
G
EMK
G
VL
GYTE
DD
V
VS
T
DFNG
EVCT
SVFDA
KA
G
--
I
A
L
N
D
-N
F
VK
L
V
S
WYDNE
T
G
Y
S
N
KV
LDLIAHISK
fig|344601.5.peg.3011
Escherichia coli B171
MT
I
KVGINGFGRIGR
I
V
F
-
R
A
A
Q
--
K
RS
D
I
E
I
VAINDL
L
DA
DY
MAY
M
LKYDS
T
HGRF
D
G
T
V
EVKD
G
H
LIV
N
GK
K
IRV
T
AER
DPA
NL
K
W
D
E
V
GVDVV
A
E
A
TG
L
F
L
T
D
E
TA
R
K
HI
T
AGAKKV
V
M
T
G
P
-
S
K
D
NTP
M
F
V
K
G
A
N
F
D
K
Y
A
G
Q
D
-
IVSNASCTTNCLAP
L
AK
V
I
N
D
N
FGI
I
E
G
L
MTT
V
HA
T
T
A
TQ
KT
VDGP
S
HKD
W
R
GG
R
G
ASQNIIP
SS
TGAAKA
V
G
K
V
L
PELNGKL
T
G
M
A
F
RVPT
P
NVSV
V
DL
T
V
R
L
E
K
A
A
T
Y
E
QIK
A
A
V
K
A
AA
E
G
EMK
G
VL
GYTE
DD
V
VS
T
DFNG
EVCT
SVFDA
KA
G
--
I
A
L
N
D
-N
F
VK
L
V
S
WYDNE
T
G
Y
S
N
KV
LDLIAHISK
fig|550676.3.peg.2092
Escherichia coli B185
MT
I
KVGINGFGRIGR
I
V
F
-
R
A
A
Q
--
K
RS
D
I
E
I
VAINDL
L
DA
DY
MAY
M
LKYDS
T
HGRF
D
G
T
V
EVKD
G
H
LIV
N
GK
K
IRV
T
AER
DPA
NL
K
W
D
E
V
GVDVV
A
E
A
TG
L
F
L
T
D
E
TA
R
K
HI
T
AGAKKV
V
M
T
G
P
-
S
K
D
NTP
M
F
V
K
G
A
N
F
D
K
Y
A
G
Q
D
-
IVSNASCTTNCLAP
L
AK
V
I
N
D
N
FGI
I
E
G
L
MTT
V
HA
T
T
A
TQ
KT
VDGP
S
HKD
W
R
GG
R
G
ASQNIIP
SS
TGAAKA
V
G
K
V
L
PELNGKL
T
G
M
A
F
RVPT
P
NVSV
V
DL
T
V
R
L
E
K
A
A
T
Y
E
QIK
A
A
V
K
A
AA
E
G
EMK
G
VL
GYTE
DD
V
VS
T
DFNG
EVCT
SVFDA
KA
G
--
I
A
L
N
D
-N
F
VK
L
V
S
WYDNE
T
G
Y
S
N
KV
LDLIAHISK
fig|550677.3.peg.1263
Escherichia coli B354
MT
I
KVGINGFGRIGR
I
V
F
-
R
A
A
Q
--
K
RS
D
I
E
I
VAINDL
L
DA
DY
MAY
M
LKYDS
T
HGRF
D
G
T
V
EVKD
G
H
LIV
N
GK
K
IRV
T
AER
DPA
NL
K
W
D
E
V
GVDVV
A
E
A
TG
L
F
L
T
D
E
TA
R
K
HI
T
AGAKKV
V
M
T
G
P
-
S
K
D
NTP
M
F
V
K
G
A
N
F
D
K
Y
A
G
Q
D
-
IVSNASCTTNCLAP
L
AK
V
I
N
D
N
FGI
I
E
G
L
MTT
V
HA
T
T
A
TQ
KT
VDGP
S
HKD
W
R
GG
R
G
ASQNIIP
SS
TGAAKA
V
G
K
V
L
PELNGKL
T
G
M
A
F
RVPT
P
NVSV
V
DL
T
V
R
L
E
K
A
A
T
Y
E
QIK
A
A
V
K
A
AA
E
G
EMK
G
VL
GYTE
DD
V
VS
T
DFNG
EVCT
SVFDA
KA
G
--
I
A
L
N
D
-N
F
VK
L
V
S
WYDNE
T
G
Y
S
N
KV
LDLIAHISK
fig|340184.3.peg.4129
Escherichia coli B7A
MT
I
KVGINGFGRIGR
I
V
F
-
R
A
A
Q
--
K
RS
D
I
E
I
VAINDL
L
DA
DY
MAY
M
LKYDS
T
HGRF
D
G
T
V
EVKD
G
H
LIV
N
GK
K
IRV
T
AER
DPA
NL
K
W
D
E
V
GVDVV
A
E
A
TG
L
F
L
T
D
E
TA
R
K
HI
T
AGAKKV
V
M
T
G
P
-
S
K
D
NTP
M
F
V
K
G
A
N
F
D
K
Y
A
G
Q
D
-
IVSNASCTTNCLAP
L
AK
V
I
N
D
N
FGI
I
E
G
L
MTT
V
HA
T
T
A
TQ
KT
VDGP
S
HKD
W
R
GG
R
G
ASQNIIP
SS
TGAAKA
V
G
K
V
L
PELNGKL
T
G
M
A
F
RVPT
P
NVSV
V
DL
T
V
R
L
E
K
A
A
T
Y
E
QIK
A
A
V
K
A
AA
E
G
EMK
G
VL
GYTE
DD
V
VS
T
DFNG
EVCT
SVFDA
KA
G
--
I
A
L
N
D
-N
F
VK
L
V
S
WYDNE
T
G
Y
S
N
KV
LDLIAHISK
fig|340184.6.peg.4325
Escherichia coli B7A
MT
I
KVGINGFGRIGR
I
V
F
-
R
A
A
Q
--
K
RS
D
I
E
I
VAINDL
L
DA
DY
MAY
M
LKYDS
T
HGRF
D
G
T
V
EVKD
G
H
LIV
N
GK
K
IRV
T
AER
DPA
NL
K
W
D
E
V
GVDVV
A
E
A
TG
L
F
L
T
D
E
TA
R
K
HI
T
AGAKKV
V
M
T
G
P
-
S
K
D
NTP
M
F
V
K
G
A
N
F
D
K
Y
A
G
Q
D
-
IVSNASCTTNCLAP
L
AK
V
I
N
D
N
FGI
I
E
G
L
MTT
V
HA
T
T
A
TQ
KT
VDGP
S
HKD
W
R
GG
R
G
ASQNIIP
SS
TGAAKA
V
G
K
V
L
PELNGKL
T
G
M
A
F
RVPT
P
NVSV
V
DL
T
V
R
L
E
K
A
A
T
Y
E
QIK
A
A
V
K
A
AA
E
G
EMK
G
VL
GYTE
DD
V
VS
T
DFNG
EVCT
SVFDA
KA
G
--
I
A
L
N
D
-N
F
VK
L
V
S
WYDNE
T
G
Y
S
N
KV
LDLIAHISK
fig|511693.5.peg.1857
Escherichia coli BL21
MT
I
KVGINGFGRIGR
I
V
F
-
R
A
A
Q
--
K
RS
D
I
E
I
VAINDL
L
DA
DY
MAY
M
LKYDS
T
HGRF
D
G
T
V
EVKD
G
H
LIV
N
GK
K
IRV
T
AER
DPA
NL
K
W
D
E
V
GVDVV
A
E
A
TG
L
F
L
T
D
E
TA
R
K
HI
T
AGAKKV
V
M
T
G
P
-
S
K
D
NTP
M
F
V
K
G
A
N
F
D
K
Y
A
G
Q
D
-
IVSNASCTTNCLAP
L
AK
V
I
N
D
N
FGI
I
E
G
L
MTT
V
HA
T
T
A
TQ
KT
VDGP
S
HKD
W
R
GG
R
G
ASQNIIP
SS
TGAAKA
V
G
K
V
L
PELNGKL
T
G
M
A
F
RVPT
P
NVSV
V
DL
T
V
R
L
E
K
A
A
T
Y
E
QIK
A
A
V
K
A
AA
E
G
EMK
G
VL
GYTE
DD
V
VS
T
DFNG
EVCT
SVFDA
KA
G
--
I
A
L
N
D
-N
F
VK
L
V
S
WYDNE
T
G
Y
S
N
KV
LDLIAHISK
fig|469008.4.peg.1921
Escherichia coli BL21(DE3)
MT
I
KVGINGFGRIGR
I
V
F
-
R
A
A
Q
--
K
RS
D
I
E
I
VAINDL
L
DA
DY
MAY
M
LKYDS
T
HGRF
D
G
T
V
EVKD
G
H
LIV
N
GK
K
IRV
T
AER
DPA
NL
K
W
D
E
V
GVDVV
A
E
A
TG
L
F
L
T
D
E
TA
R
K
HI
T
AGAKKV
V
M
T
G
P
-
S
K
D
NTP
M
F
V
K
G
A
N
F
D
K
Y
A
G
Q
D
-
IVSNASCTTNCLAP
L
AK
V
I
N
D
N
FGI
I
E
G
L
MTT
V
HA
T
T
A
TQ
KT
VDGP
S
HKD
W
R
GG
R
G
ASQNIIP
SS
TGAAKA
V
G
K
V
L
PELNGKL
T
G
M
A
F
RVPT
P
NVSV
V
DL
T
V
R
L
E
K
A
A
T
Y
E
QIK
A
A
V
K
A
AA
E
G
EMK
G
VL
GYTE
DD
V
VS
T
DFNG
EVCT
SVFDA
KA
G
--
I
A
L
N
D
-N
F
VK
L
V
S
WYDNE
T
G
Y
S
N
KV
LDLIAHISK
fig|595496.3.peg.1743
Escherichia coli BW2952
MT
I
KVGINGFGRIGR
I
V
F
-
R
A
A
Q
--
K
RS
D
I
E
I
VAINDL
L
DA
DY
MAY
M
LKYDS
T
HGRF
D
G
T
V
EVKD
G
H
LIV
N
GK
K
IRV
T
AER
DPA
NL
K
W
D
E
V
GVDVV
A
E
A
TG
L
F
L
T
D
E
TA
R
K
HI
T
AGAKKV
V
M
T
G
P
-
S
K
D
NTP
M
F
V
K
G
A
N
F
D
K
Y
A
G
Q
D
-
IVSNASCTTNCLAP
L
AK
V
I
N
D
N
FGI
I
E
G
L
MTT
V
HA
T
T
A
TQ
KT
VDGP
S
HKD
W
R
GG
R
G
ASQNIIP
SS
TGAAKA
V
G
K
V
L
PELNGKL
T
G
M
A
F
RVPT
P
NVSV
V
DL
T
V
R
L
E
K
A
A
T
Y
E
QIK
A
A
V
K
A
AA
E
G
EMK
G
VL
GYTE
DD
V
VS
T
DFNG
EVCT
SVFDA
KA
G
--
I
A
L
N
D
-N
F
VK
L
V
S
WYDNE
T
G
Y
S
N
KV
LDLIAHISK
fig|199310.1.peg.2121
Escherichia coli CFT073 (4-334/334)
MT
I
KVGINGFGRIGR
I
V
F
-
R
A
A
Q
--
K
RS
D
I
E
I
VAINDL
L
DA
DY
MAY
M
LKYDS
T
HGRF
D
G
T
V
EVKD
G
H
LIV
N
GK
K
IRV
T
AER
DPA
NL
K
W
D
E
V
GVDVV
A
E
A
TG
L
F
L
T
D
E
TA
R
K
HI
T
AGAKKV
V
M
T
G
P
-
S
K
D
NTP
M
F
V
K
G
A
N
F
D
K
Y
A
G
Q
D
-
IVSNASCTTNCLAP
L
AK
V
I
N
D
N
FGI
I
E
G
L
MTT
V
HA
T
T
A
TQ
KT
VDGP
S
HKD
W
R
GG
R
G
ASQNIIP
SS
TGAAKA
V
G
K
V
L
PELNGKL
T
G
M
A
F
RVPT
P
NVSV
V
DL
T
V
R
L
E
K
A
A
T
Y
E
QIK
A
A
V
K
A
AA
E
G
EMK
G
VL
GYTE
DD
V
VS
T
DFNG
EVCT
SVFDA
KA
G
--
I
A
L
N
D
-N
F
VK
L
V
S
WYDNE
T
G
Y
S
N
KV
LDLIAHISK
fig|199310.4.peg.2046
Escherichia coli CFT073
MT
I
KVGINGFGRIGR
I
V
F
-
R
A
A
Q
--
K
RS
D
I
E
I
VAINDL
L
DA
DY
MAY
M
LKYDS
T
HGRF
D
G
T
V
EVKD
G
H
LIV
N
GK
K
IRV
T
AER
DPA
NL
K
W
D
E
V
GVDVV
A
E
A
TG
L
F
L
T
D
E
TA
R
K
HI
T
AGAKKV
V
M
T
G
P
-
S
K
D
NTP
M
F
V
K
G
A
N
F
D
K
Y
A
G
Q
D
-
IVSNASCTTNCLAP
L
AK
V
I
N
D
N
FGI
I
E
G
L
MTT
V
HA
T
T
A
TQ
KT
VDGP
S
HKD
W
R
GG
R
G
ASQNIIP
SS
TGAAKA
V
G
K
V
L
PELNGKL
T
G
M
A
F
RVPT
P
NVSV
V
DL
T
V
R
L
E
K
A
A
T
Y
E
QIK
A
A
V
K
A
AA
E
G
EMK
G
VL
GYTE
DD
V
VS
T
DFNG
EVCT
SVFDA
KA
G
--
I
A
L
N
D
-N
F
VK
L
V
S
WYDNE
T
G
Y
S
N
KV
LDLIAHISK
fig|536056.3.peg.1971
Escherichia coli DH1
MT
I
KVGINGFGRIGR
I
V
F
-
R
A
A
Q
--
K
RS
D
I
E
I
VAINDL
L
DA
DY
MAY
M
LKYDS
T
HGRF
D
G
T
V
EVKD
G
H
LIV
N
GK
K
IRV
T
AER
DPA
NL
K
W
D
E
V
GVDVV
A
E
A
TG
L
F
L
T
D
E
TA
R
K
HI
T
AGAKKV
V
M
T
G
P
-
S
K
D
NTP
M
F
V
K
G
A
N
F
D
K
Y
A
G
Q
D
-
IVSNASCTTNCLAP
L
AK
V
I
N
D
N
FGI
I
E
G
L
MTT
V
HA
T
T
A
TQ
KT
VDGP
S
HKD
W
R
GG
R
G
ASQNIIP
SS
TGAAKA
V
G
K
V
L
PELNGKL
T
G
M
A
F
RVPT
P
NVSV
V
DL
T
V
R
L
E
K
A
A
T
Y
E
QIK
A
A
V
K
A
AA
E
G
EMK
G
VL
GYTE
DD
V
VS
T
DFNG
EVCT
SVFDA
KA
G
--
I
A
L
N
D
-N
F
VK
L
V
S
WYDNE
T
G
Y
S
N
KV
LDLIAHISK
fig|340186.3.peg.2084
Escherichia coli E110019
MT
I
KVGINGFGRIGR
I
V
F
-
R
A
A
Q
--
K
RS
D
I
E
I
VAINDL
L
DA
DY
MAY
M
LKYDS
T
HGRF
D
G
T
V
EVKD
G
H
LIV
N
GK
K
IRV
T
AER
DPA
NL
K
W
D
E
V
GVDVV
A
E
A
TG
L
F
L
T
D
E
TA
R
K
HI
T
AGAKKV
V
M
T
G
P
-
S
K
D
NTP
M
F
V
K
G
A
N
F
D
K
Y
A
G
Q
D
-
IVSNASCTTNCLAP
L
AK
V
I
N
D
N
FGI
I
E
G
L
MTT
V
HA
T
T
A
TQ
KT
VDGP
S
HKD
W
R
GG
R
G
ASQNIIP
SS
TGAAKA
V
G
K
V
L
PELNGKL
T
G
M
A
F
RVPT
P
NVSV
V
DL
T
V
R
L
E
K
A
A
T
Y
E
QIK
A
A
V
K
A
AA
E
G
EMK
G
VL
GYTE
DD
V
VS
T
DFNG
EVCT
SVFDA
KA
G
--
I
A
L
N
D
-N
F
VK
L
V
S
WYDNE
T
G
Y
S
N
KV
LDLIAHISK
fig|340186.5.peg.2148
Escherichia coli E110019
MT
I
KVGINGFGRIGR
I
V
F
-
R
A
A
Q
--
K
RS
D
I
E
I
VAINDL
L
DA
DY
MAY
M
LKYDS
T
HGRF
D
G
T
V
EVKD
G
H
LIV
N
GK
K
IRV
T
AER
DPA
NL
K
W
D
E
V
GVDVV
A
E
A
TG
L
F
L
T
D
E
TA
R
K
HI
T
AGAKKV
V
M
T
G
P
-
S
K
D
NTP
M
F
V
K
G
A
N
F
D
K
Y
A
G
Q
D
-
IVSNASCTTNCLAP
L
AK
V
I
N
D
N
FGI
I
E
G
L
MTT
V
HA
T
T
A
TQ
KT
VDGP
S
HKD
W
R
GG
R
G
ASQNIIP
SS
TGAAKA
V
G
K
V
L
PELNGKL
T
G
M
A
F
RVPT
P
NVSV
V
DL
T
V
R
L
E
K
A
A
T
Y
E
QIK
A
A
V
K
A
AA
E
G
EMK
G
VL
GYTE
DD
V
VS
T
DFNG
EVCT
SVFDA
KA
G
--
I
A
L
N
D
-N
F
VK
L
V
S
WYDNE
T
G
Y
S
N
KV
LDLIAHISK
fig|216593.1.peg.606
Escherichia coli E2348/69 (4-334/334)
MT
I
KVGINGFGRIGR
I
V
F
-
R
A
A
Q
--
K
RS
D
I
E
I
VAINDL
L
DA
DY
MAY
M
LKYDS
T
HGRF
D
G
T
V
EVKD
G
H
LIV
N
GK
K
IRV
T
AER
DPA
NL
K
W
D
E
V
GVDVV
A
E
A
TG
L
F
L
T
D
E
TA
R
K
HI
T
AGAKKV
V
M
T
G
P
-
S
K
D
NTP
M
F
V
K
G
A
N
F
D
K
Y
A
G
Q
D
-
IVSNASCTTNCLAP
L
AK
V
I
N
D
N
FGI
I
E
G
L
MTT
V
HA
T
T
A
TQ
KT
VDGP
S
HKD
W
R
GG
R
G
ASQNIIP
SS
TGAAKA
V
G
K
V
L
PELNGKL
T
G
M
A
F
RVPT
P
NVSV
V
DL
T
V
R
L
E
K
A
A
T
Y
E
QIK
A
A
V
K
A
AA
E
G
EMK
G
VL
GYTE
DD
V
VS
T
DFNG
EVCT
SVFDA
KA
G
--
I
A
L
N
D
-N
F
VK
L
V
S
WYDNE
T
G
Y
S
N
KV
LDLIAHISK
fig|331111.12.peg.2279
Escherichia coli E24377A
MT
I
KVGINGFGRIGR
I
V
F
-
R
A
A
Q
--
K
RS
D
I
E
I
VAINDL
L
DA
DY
MAY
M
LKYDS
T
HGRF
D
G
T
V
EVKD
G
H
LIV
N
GK
K
IRV
T
AER
DPA
NL
K
W
D
E
V
GVDVV
A
E
A
TG
L
F
L
T
D
E
TA
R
K
HI
T
AGAKKV
V
M
T
G
P
-
S
K
D
NTP
M
F
V
K
G
A
N
F
D
K
Y
A
G
Q
D
-
IVSNASCTTNCLAP
L
AK
V
I
N
D
N
FGI
I
E
G
L
MTT
V
HA
T
T
A
TQ
KT
VDGP
S
HKD
W
R
GG
R
G
ASQNIIP
SS
TGAAKA
V
G
K
V
L
PELNGKL
T
G
M
A
F
RVPT
P
NVSV
V
DL
T
V
R
L
E
K
A
A
T
Y
E
QIK
A
A
V
K
A
AA
E
G
EMK
G
VL
GYTE
DD
V
VS
T
DFNG
EVCT
SVFDA
KA
G
--
I
A
L
N
D
-N
F
VK
L
V
S
WYDNE
T
G
Y
S
N
KV
LDLIAHISK
fig|331111.3.peg.4422
Escherichia coli E24377A
MT
I
KVGINGFGRIGR
I
V
F
-
R
A
A
Q
--
K
RS
D
I
E
I
VAINDL
L
DA
DY
MAY
M
LKYDS
T
HGRF
D
G
T
V
EVKD
G
H
LIV
N
GK
K
IRV
T
AER
DPA
NL
K
W
D
E
V
GVDVV
A
E
A
TG
L
F
L
T
D
E
TA
R
K
HI
T
AGAKKV
V
M
T
G
P
-
S
K
D
NTP
M
F
V
K
G
A
N
F
D
K
Y
A
G
Q
D
-
IVSNASCTTNCLAP
L
AK
V
I
N
D
N
FGI
I
E
G
L
MTT
V
HA
T
T
A
TQ
KT
VDGP
S
HKD
W
R
GG
R
G
ASQNIIP
SS
TGAAKA
V
G
K
V
L
PELNGKL
T
G
M
A
F
RVPT
P
NVSV
V
DL
T
V
R
L
E
K
A
A
T
Y
E
QIK
A
A
V
K
A
AA
E
G
EMK
G
VL
GYTE
DD
V
VS
T
DFNG
EVCT
SVFDA
KA
G
--
I
A
L
N
D
-N
F
VK
L
V
S
WYDNE
T
G
Y
S
N
KV
LDLIAHISK
fig|562.375.peg.1889
Escherichia coli EC4100B
MT
I
KVGINGFGRIGR
I
V
F
-
R
A
A
Q
--
K
RS
D
I
E
I
VAINDL
L
DA
DY
MAY
M
LKYDS
T
HGRF
D
G
T
V
EVKD
G
H
LIV
N
GK
K
IRV
T
AER
DPA
NL
K
W
D
E
V
GVDVV
A
E
A
TG
L
F
L
T
D
E
TA
R
K
HI
T
AGAKKV
V
M
T
G
P
-
S
K
D
NTP
M
F
V
K
G
A
N
F
D
K
Y
A
G
Q
D
-
IVSNASCTTNCLAP
L
AK
V
I
N
D
N
FGI
I
E
G
L
MTT
V
HA
T
T
A
TQ
KT
VDGP
S
HKD
W
R
GG
R
G
ASQNIIP
SS
TGAAKA
V
G
K
V
L
PELNGKL
T
G
M
A
F
RVPT
P
NVSV
V
DL
T
V
R
L
E
K
A
A
T
Y
E
QIK
A
A
V
K
A
AA
E
G
EMK
G
VL
GYTE
DD
V
VS
T
DFNG
EVCT
SVFDA
KA
G
--
I
A
L
N
D
-N
F
VK
L
V
S
WYDNE
T
G
Y
S
N
KV
LDLIAHISK
fig|585397.7.peg.2007
Escherichia coli ED1a
MT
I
KVGINGFGRIGR
I
V
F
-
R
A
A
Q
--
K
RS
D
I
E
I
VAINDL
L
DA
DY
MAY
M
LKYDS
T
HGRF
D
G
T
V
EVKD
G
H
LIV
N
GK
K
IRV
T
AER
DPA
NL
K
W
D
E
V
GVDVV
A
E
A
TG
L
F
L
T
D
E
TA
R
K
HI
T
AGAKKV
V
M
T
G
P
-
S
K
D
NTP
M
F
V
K
G
A
N
F
D
K
Y
A
G
Q
D
-
IVSNASCTTNCLAP
L
AK
V
I
N
D
N
FGI
I
E
G
L
MTT
V
HA
T
T
A
TQ
KT
VDGP
S
HKD
W
R
GG
R
G
ASQNIIP
SS
TGAAKA
V
G
K
V
L
PELNGKL
T
G
M
A
F
RVPT
P
NVSV
V
DL
T
V
R
L
E
K
A
A
T
Y
E
QIK
A
A
V
K
A
AA
E
G
EMK
G
VL
GYTE
DD
V
VS
T
DFNG
EVCT
SVFDA
KA
G
--
I
A
L
N
D
-N
F
VK
L
V
S
WYDNE
T
G
Y
S
N
KV
LDLIAHISK
fig|585397.9.peg.2002
Escherichia coli ED1a
MT
I
KVGINGFGRIGR
I
V
F
-
R
A
A
Q
--
K
RS
D
I
E
I
VAINDL
L
DA
DY
MAY
M
LKYDS
T
HGRF
D
G
T
V
EVKD
G
H
LIV
N
GK
K
IRV
T
AER
DPA
NL
K
W
D
E
V
GVDVV
A
E
A
TG
L
F
L
T
D
E
TA
R
K
HI
T
AGAKKV
V
M
T
G
P
-
S
K
D
NTP
M
F
V
K
G
A
N
F
D
K
Y
A
G
Q
D
-
IVSNASCTTNCLAP
L
AK
V
I
N
D
N
FGI
I
E
G
L
MTT
V
HA
T
T
A
TQ
KT
VDGP
S
HKD
W
R
GG
R
G
ASQNIIP
SS
TGAAKA
V
G
K
V
L
PELNGKL
T
G
M
A
F
RVPT
P
NVSV
V
DL
T
V
R
L
E
K
A
A
T
Y
E
QIK
A
A
V
K
A
AA
E
G
EMK
G
VL
GYTE
DD
V
VS
T
DFNG
EVCT
SVFDA
KA
G
--
I
A
L
N
D
-N
F
VK
L
V
S
WYDNE
T
G
Y
S
N
KV
LDLIAHISK
fig|316401.4.peg.2074
Escherichia coli ETEC H10407
MT
I
KVGINGFGRIGR
I
V
F
-
R
A
A
Q
--
K
RS
D
I
E
I
VAINDL
L
DA
DY
MAY
M
LKYDS
T
HGRF
D
G
T
V
EVKD
G
H
LIV
N
GK
K
IRV
T
AER
DPA
NL
K
W
D
E
V
GVDVV
A
E
A
TG
L
F
L
T
D
E
TA
R
K
HI
T
AGAKKV
V
M
T
G
P
-
S
K
D
NTP
M
F
V
K
G
A
N
F
D
K
Y
A
G
Q
D
-
IVSNASCTTNCLAP
L
AK
V
I
N
D
N
FGI
I
E
G
L
MTT
V
HA
T
T
A
TQ
KT
VDGP
S
HKD
W
R
GG
R
G
ASQNIIP
SS
TGAAKA
V
G
K
V
L
PELNGKL
T
G
M
A
F
RVPT
P
NVSV
V
DL
T
V
R
L
E
K
A
A
T
Y
E
QIK
A
A
V
K
A
AA
E
G
EMK
G
VL
GYTE
DD
V
VS
T
DFNG
EVCT
SVFDA
KA
G
--
I
A
L
N
D
-N
F
VK
L
V
S
WYDNE
T
G
Y
S
N
KV
LDLIAHISK
fig|340197.3.peg.1762
Escherichia coli F11
MT
I
KVGINGFGRIGR
I
V
F
-
R
A
A
Q
--
K
RS
D
I
E
I
VAINDL
L
DA
DY
MAY
M
LKYDS
T
HGRF
D
G
T
V
EVKD
G
H
LIV
N
GK
K
IRV
T
AER
DPA
NL
K
W
D
E
V
GVDVV
A
E
A
TG
L
F
L
T
D
E
TA
R
K
HI
T
AGAKKV
V
M
T
G
P
-
S
K
D
NTP
M
F
V
K
G
A
N
F
D
K
Y
A
G
Q
D
-
IVSNASCTTNCLAP
L
AK
V
I
N
D
N
FGI
I
E
G
L
MTT
V
HA
T
T
A
TQ
KT
VDGP
S
HKD
W
R
GG
R
G
ASQNIIP
SS
TGAAKA
V
G
K
V
L
PELNGKL
T
G
M
A
F
RVPT
P
NVSV
V
DL
T
V
R
L
E
K
A
A
T
Y
E
QIK
A
A
V
K
A
AA
E
G
EMK
G
VL
GYTE
DD
V
VS
T
DFNG
EVCT
SVFDA
KA
G
--
I
A
L
N
D
-N
F
VK
L
V
S
WYDNE
T
G
Y
S
N
KV
LDLIAHISK
fig|340197.5.peg.1859
Escherichia coli F11
MT
I
KVGINGFGRIGR
I
V
F
-
R
A
A
Q
--
K
RS
D
I
E
I
VAINDL
L
DA
DY
MAY
M
LKYDS
T
HGRF
D
G
T
V
EVKD
G
H
LIV
N
GK
K
IRV
T
AER
DPA
NL
K
W
D
E
V
GVDVV
A
E
A
TG
L
F
L
T
D
E
TA
R
K
HI
T
AGAKKV
V
M
T
G
P
-
S
K
D
NTP
M
F
V
K
G
A
N
F
D
K
Y
A
G
Q
D
-
IVSNASCTTNCLAP
L
AK
V
I
N
D
N
FGI
I
E
G
L
MTT
V
HA
T
T
A
TQ
KT
VDGP
S
HKD
W
R
GG
R
G
ASQNIIP
SS
TGAAKA
V
G
K
V
L
PELNGKL
T
G
M
A
F
RVPT
P
NVSV
V
DL
T
V
R
L
E
K
A
A
T
Y
E
QIK
A
A
V
K
A
AA
E
G
EMK
G
VL
GYTE
DD
V
VS
T
DFNG
EVCT
SVFDA
KA
G
--
I
A
L
N
D
-N
F
VK
L
V
S
WYDNE
T
G
Y
S
N
KV
LDLIAHISK
fig|656379.3.peg.2252
Escherichia coli FVEC1302
MT
I
KVGINGFGRIGR
I
V
F
-
R
A
A
Q
--
K
RS
D
I
E
I
VAINDL
L
DA
DY
MAY
M
LKYDS
T
HGRF
D
G
T
V
EVKD
G
H
LIV
N
GK
K
IRV
T
AER
DPA
NL
K
W
D
E
V
GVDVV
A
E
A
TG
L
F
L
T
D
E
TA
R
K
HI
T
AGAKKV
V
M
T
G
P
-
S
K
D
NTP
M
F
V
K
G
A
N
F
D
K
Y
A
G
Q
D
-
IVSNASCTTNCLAP
L
AK
V
I
N
D
N
FGI
I
E
G
L
MTT
V
HA
T
T
A
TQ
KT
VDGP
S
HKD
W
R
GG
R
G
ASQNIIP
SS
TGAAKA
V
G
K
V
L
PELNGKL
T
G
M
A
F
RVPT
P
NVSV
V
DL
T
V
R
L
E
K
A
A
T
Y
E
QIK
A
A
V
K
A
AA
E
G
EMK
G
VL
GYTE
DD
V
VS
T
DFNG
EVCT
SVFDA
KA
G
--
I
A
L
N
D
-N
F
VK
L
V
S
WYDNE
T
G
Y
S
N
KV
LDLIAHISK
fig|656380.3.peg.3216
Escherichia coli FVEC1412
MT
I
KVGINGFGRIGR
I
V
F
-
R
A
A
Q
--
K
RS
D
I
E
I
VAINDL
L
DA
DY
MAY
M
LKYDS
T
HGRF
D
G
T
V
EVKD
G
H
LIV
N
GK
K
IRV
T
AER
DPA
NL
K
W
D
E
V
GVDVV
A
E
A
TG
L
F
L
T
D
E
TA
R
K
HI
T
AGAKKV
V
M
T
G
P
-
S
K
D
NTP
M
F
V
K
G
A
N
F
D
K
Y
A
G
Q
D
-
IVSNASCTTNCLAP
L
AK
V
I
N
D
N
FGI
I
E
G
L
MTT
V
HA
T
T
A
TQ
KT
VDGP
S
HKD
W
R
GG
R
G
ASQNIIP
SS
TGAAKA
V
G
K
V
L
PELNGKL
T
G
M
A
F
RVPT
P
NVSV
V
DL
T
V
R
L
E
K
A
A
T
Y
E
QIK
A
A
V
K
A
AA
E
G
EMK
G
VL
GYTE
DD
V
VS
T
DFNG
EVCT
SVFDA
KA
G
--
I
A
L
N
D
-N
F
VK
L
V
S
WYDNE
T
G
Y
S
N
KV
LDLIAHISK
fig|656393.3.peg.2571
Escherichia coli H299
MT
I
KVGINGFGRIGR
I
V
F
-
R
A
A
Q
--
K
RS
D
I
E
I
VAINDL
L
DA
DY
MAY
M
LKYDS
T
HGRF
D
G
T
V
EVKD
G
H
LIV
N
GK
K
IRV
T
AER
DPA
NL
K
W
D
E
V
GVDVV
A
E
A
TG
L
F
L
T
D
E
TA
R
K
HI
T
AGAKKV
V
M
T
G
P
-
S
K
D
NTP
M
F
V
K
G
A
N
F
D
K
Y
A
G
Q
D
-
IVSNASCTTNCLAP
L
AK
V
I
N
D
N
FGI
I
E
G
L
MTT
V
HA
T
T
A
TQ
KT
VDGP
S
HKD
W
R
GG
R
G
ASQNIIP
SS
TGAAKA
V
G
K
V
L
PELNGKL
T
G
M
A
F
RVPT
P
NVSV
V
DL
T
V
R
L
E
K
A
A
T
Y
E
QIK
A
A
V
K
A
AA
E
G
EMK
G
VL
GYTE
DD
V
VS
T
DFNG
EVCT
SVFDA
KA
G
--
I
A
L
N
D
-N
F
VK
L
V
S
WYDNE
T
G
Y
S
N
KV
LDLIAHISK
fig|656408.3.peg.1938
Escherichia coli H591
MT
I
KVGINGFGRIGR
I
V
F
-
R
A
A
Q
--
K
RS
D
I
E
I
VAINDL
L
DA
DY
MAY
M
LKYDS
T
HGRF
D
G
T
V
EVKD
G
H
LIV
N
GK
K
IRV
T
AER
DPA
NL
K
W
D
E
V
GVDVV
A
E
A
TG
L
F
L
T
D
E
TA
R
K
HI
T
AGAKKV
V
M
T
G
P
-
S
K
D
NTP
M
F
V
K
G
A
N
F
D
K
Y
A
G
Q
D
-
IVSNASCTTNCLAP
L
AK
V
I
N
D
N
FGI
I
E
G
L
MTT
V
HA
T
T
A
TQ
KT
VDGP
S
HKD
W
R
GG
R
G
ASQNIIP
SS
TGAAKA
V
G
K
V
L
PELNGKL
T
G
M
A
F
RVPT
P
NVSV
V
DL
T
V
R
L
E
K
A
A
T
Y
E
QIK
A
A
V
K
A
AA
E
G
EMK
G
VL
GYTE
DD
V
VS
T
DFNG
EVCT
SVFDA
KA
G
--
I
A
L
N
D
-N
F
VK
L
V
S
WYDNE
T
G
Y
S
N
KV
LDLIAHISK
fig|656414.3.peg.2107
Escherichia coli H736
MT
I
KVGINGFGRIGR
I
V
F
-
R
A
A
Q
--
K
RS
D
I
E
I
VAINDL
L
DA
DY
MAY
M
LKYDS
T
HGRF
D
G
T
V
EVKD
G
H
LIV
N
GK
K
IRV
T
AER
DPA
NL
K
W
D
E
V
GVDVV
A
E
A
TG
L
F
L
T
D
E
TA
R
K
HI
T
AGAKKV
V
M
T
G
P
-
S
K
D
NTP
M
F
V
K
G
A
N
F
D
K
Y
A
G
Q
D
-
IVSNASCTTNCLAP
L
AK
V
I
N
D
N
FGI
I
E
G
L
MTT
V
HA
T
T
A
TQ
KT
VDGP
S
HKD
W
R
GG
R
G
ASQNIIP
SS
TGAAKA
V
G
K
V
L
PELNGKL
T
G
M
A
F
RVPT
P
NVSV
V
DL
T
V
R
L
E
K
A
A
T
Y
E
QIK
A
A
V
K
A
AA
E
G
EMK
G
VL
GYTE
DD
V
VS
T
DFNG
EVCT
SVFDA
KA
G
--
I
A
L
N
D
-N
F
VK
L
V
S
WYDNE
T
G
Y
S
N
KV
LDLIAHISK
fig|331112.3.peg.1757
Escherichia coli HS
MT
I
KVGINGFGRIGR
I
V
F
-
R
A
A
Q
--
K
RS
D
I
E
I
VAINDL
L
DA
DY
MAY
M
LKYDS
T
HGRF
D
G
T
V
EVKD
G
H
LIV
N
GK
K
IRV
T
AER
DPA
NL
K
W
D
E
V
GVDVV
A
E
A
TG
L
F
L
T
D
E
TA
R
K
HI
T
AGAKKV
V
M
T
G
P
-
S
K
D
NTP
M
F
V
K
G
A
N
F
D
K
Y
A
G
Q
D
-
IVSNASCTTNCLAP
L
AK
V
I
N
D
N
FGI
I
E
G
L
MTT
V
HA
T
T
A
TQ
KT
VDGP
S
HKD
W
R
GG
R
G
ASQNIIP
SS
TGAAKA
V
G
K
V
L
PELNGKL
T
G
M
A
F
RVPT
P
NVSV
V
DL
T
V
R
L
E
K
A
A
T
Y
E
QIK
A
A
V
K
A
AA
E
G
EMK
G
VL
GYTE
DD
V
VS
T
DFNG
EVCT
SVFDA
KA
G
--
I
A
L
N
D
-N
F
VK
L
V
S
WYDNE
T
G
Y
S
N
KV
LDLIAHISK
fig|331112.6.peg.1825
Escherichia coli HS
MT
I
KVGINGFGRIGR
I
V
F
-
R
A
A
Q
--
K
RS
D
I
E
I
VAINDL
L
DA
DY
MAY
M
LKYDS
T
HGRF
D
G
T
V
EVKD
G
H
LIV
N
GK
K
IRV
T
AER
DPA
NL
K
W
D
E
V
GVDVV
A
E
A
TG
L
F
L
T
D
E
TA
R
K
HI
T
AGAKKV
V
M
T
G
P
-
S
K
D
NTP
M
F
V
K
G
A
N
F
D
K
Y
A
G
Q
D
-
IVSNASCTTNCLAP
L
AK
V
I
N
D
N
FGI
I
E
G
L
MTT
V
HA
T
T
A
TQ
KT
VDGP
S
HKD
W
R
GG
R
G
ASQNIIP
SS
TGAAKA
V
G
K
V
L
PELNGKL
T
G
M
A
F
RVPT
P
NVSV
V
DL
T
V
R
L
E
K
A
A
T
Y
E
QIK
A
A
V
K
A
AA
E
G
EMK
G
VL
GYTE
DD
V
VS
T
DFNG
EVCT
SVFDA
KA
G
--
I
A
L
N
D
-N
F
VK
L
V
S
WYDNE
T
G
Y
S
N
KV
LDLIAHISK
fig|585034.4.peg.1819
Escherichia coli IAI1
MT
I
KVGINGFGRIGR
I
V
F
-
R
A
A
Q
--
K
RS
D
I
E
I
VAINDL
L
DA
DY
MAY
M
LKYDS
T
HGRF
D
G
T
V
EVKD
G
H
LIV
N
GK
K
IRV
T
AER
DPA
NL
K
W
D
E
V
GVDVV
A
E
A
TG
L
F
L
T
D
E
TA
R
K
HI
T
AGAKKV
V
M
T
G
P
-
S
K
D
NTP
M
F
V
K
G
A
N
F
D
K
Y
A
G
Q
D
-
IVSNASCTTNCLAP
L
AK
V
I
N
D
N
FGI
I
E
G
L
MTT
V
HA
T
T
A
TQ
KT
VDGP
S
HKD
W
R
GG
R
G
ASQNIIP
SS
TGAAKA
V
G
K
V
L
PELNGKL
T
G
M
A
F
RVPT
P
NVSV
V
DL
T
V
R
L
E
K
A
A
T
Y
E
QIK
A
A
V
K
A
AA
E
G
EMK
G
VL
GYTE
DD
V
VS
T
DFNG
EVCT
SVFDA
KA
G
--
I
A
L
N
D
-N
F
VK
L
V
S
WYDNE
T
G
Y
S
N
KV
LDLIAHISK
fig|585034.5.peg.1814
Escherichia coli IAI1
MT
I
KVGINGFGRIGR
I
V
F
-
R
A
A
Q
--
K
RS
D
I
E
I
VAINDL
L
DA
DY
MAY
M
LKYDS
T
HGRF
D
G
T
V
EVKD
G
H
LIV
N
GK
K
IRV
T
AER
DPA
NL
K
W
D
E
V
GVDVV
A
E
A
TG
L
F
L
T
D
E
TA
R
K
HI
T
AGAKKV
V
M
T
G
P
-
S
K
D
NTP
M
F
V
K
G
A
N
F
D
K
Y
A
G
Q
D
-
IVSNASCTTNCLAP
L
AK
V
I
N
D
N
FGI
I
E
G
L
MTT
V
HA
T
T
A
TQ
KT
VDGP
S
HKD
W
R
GG
R
G
ASQNIIP
SS
TGAAKA
V
G
K
V
L
PELNGKL
T
G
M
A
F
RVPT
P
NVSV
V
DL
T
V
R
L
E
K
A
A
T
Y
E
QIK
A
A
V
K
A
AA
E
G
EMK
G
VL
GYTE
DD
V
VS
T
DFNG
EVCT
SVFDA
KA
G
--
I
A
L
N
D
-N
F
VK
L
V
S
WYDNE
T
G
Y
S
N
KV
LDLIAHISK
fig|585057.4.peg.1334
Escherichia coli IAI39
MT
I
KVGINGFGRIGR
I
V
F
-
R
A
A
Q
--
K
RS
D
I
E
I
VAINDL
L
DA
DY
MAY
M
LKYDS
T
HGRF
D
G
T
V
EVKD
G
H
LIV
N
GK
K
IRV
T
AER
DPA
NL
K
W
D
E
V
GVDVV
A
E
A
TG
L
F
L
T
D
E
TA
R
K
HI
T
AGAKKV
V
M
T
G
P
-
S
K
D
NTP
M
F
V
K
G
A
N
F
D
K
Y
A
G
Q
D
-
IVSNASCTTNCLAP
L
AK
V
I
N
D
N
FGI
I
E
G
L
MTT
V
HA
T
T
A
TQ
KT
VDGP
S
HKD
W
R
GG
R
G
ASQNIIP
SS
TGAAKA
V
G
K
V
L
PELNGKL
T
G
M
A
F
RVPT
P
NVSV
V
DL
T
V
R
L
E
K
A
A
T
Y
E
QIK
A
A
V
K
A
AA
E
G
EMK
G
VL
GYTE
DD
V
VS
T
DFNG
EVCT
SVFDA
KA
G
--
I
A
L
N
D
-N
F
VK
L
V
S
WYDNE
T
G
Y
S
N
KV
LDLIAHISK
fig|585057.6.peg.1333
Escherichia coli IAI39
MT
I
KVGINGFGRIGR
I
V
F
-
R
A
A
Q
--
K
RS
D
I
E
I
VAINDL
L
DA
DY
MAY
M
LKYDS
T
HGRF
D
G
T
V
EVKD
G
H
LIV
N
GK
K
IRV
T
AER
DPA
NL
K
W
D
E
V
GVDVV
A
E
A
TG
L
F
L
T
D
E
TA
R
K
HI
T
AGAKKV
V
M
T
G
P
-
S
K
D
NTP
M
F
V
K
G
A
N
F
D
K
Y
A
G
Q
D
-
IVSNASCTTNCLAP
L
AK
V
I
N
D
N
FGI
I
E
G
L
MTT
V
HA
T
T
A
TQ
KT
VDGP
S
HKD
W
R
GG
R
G
ASQNIIP
SS
TGAAKA
V
G
K
V
L
PELNGKL
T
G
M
A
F
RVPT
P
NVSV
V
DL
T
V
R
L
E
K
A
A
T
Y
E
QIK
A
A
V
K
A
AA
E
G
EMK
G
VL
GYTE
DD
V
VS
T
DFNG
EVCT
SVFDA
KA
G
--
I
A
L
N
D
-N
F
VK
L
V
S
WYDNE
T
G
Y
S
N
KV
LDLIAHISK
fig|714962.3.peg.1934
Escherichia coli IHE3034
MT
I
KVGINGFGRIGR
I
V
F
-
R
A
A
Q
--
K
RS
D
I
E
I
VAINDL
L
DA
DY
MAY
M
LKYDS
T
HGRF
D
G
T
V
EVKD
G
H
LIV
N
GK
K
IRV
T
AER
DPA
NL
K
W
D
E
V
GVDVV
A
E
A
TG
L
F
L
T
D
E
TA
R
K
HI
T
AGAKKV
V
M
T
G
P
-
S
K
D
NTP
M
F
V
K
G
A
N
F
D
K
Y
A
G
Q
D
-
IVSNASCTTNCLAP
L
AK
V
I
N
D
N
FGI
I
E
G
L
MTT
V
HA
T
T
A
TQ
KT
VDGP
S
HKD
W
R
GG
R
G
ASQNIIP
SS
TGAAKA
V
G
K
V
L
PELNGKL
T
G
M
A
F
RVPT
P
NVSV
V
DL
T
V
R
L
E
K
A
A
T
Y
E
QIK
A
A
V
K
A
AA
E
G
EMK
G
VL
GYTE
DD
V
VS
T
DFNG
EVCT
SVFDA
KA
G
--
I
A
L
N
D
-N
F
VK
L
V
S
WYDNE
T
G
Y
S
N
KV
LDLIAHISK
fig|83333.1.peg.1762
Escherichia coli K12
MT
I
KVGINGFGRIGR
I
V
F
-
R
A
A
Q
--
K
RS
D
I
E
I
VAINDL
L
DA
DY
MAY
M
LKYDS
T
HGRF
D
G
T
V
EVKD
G
H
LIV
N
GK
K
IRV
T
AER
DPA
NL
K
W
D
E
V
GVDVV
A
E
A
TG
L
F
L
T
D
E
TA
R
K
HI
T
AGAKKV
V
M
T
G
P
-
S
K
D
NTP
M
F
V
K
G
A
N
F
D
K
Y
A
G
Q
D
-
IVSNASCTTNCLAP
L
AK
V
I
N
D
N
FGI
I
E
G
L
MTT
V
HA
T
T
A
TQ
KT
VDGP
S
HKD
W
R
GG
R
G
ASQNIIP
SS
TGAAKA
V
G
K
V
L
PELNGKL
T
G
M
A
F
RVPT
P
NVSV
V
DL
T
V
R
L
E
K
A
A
T
Y
E
QIK
A
A
V
K
A
AA
E
G
EMK
G
VL
GYTE
DD
V
VS
T
DFNG
EVCT
SVFDA
KA
G
--
I
A
L
N
D
-N
F
VK
L
V
S
WYDNE
T
G
Y
S
N
KV
LDLIAHISK
fig|595495.4.peg.2334
Escherichia coli KO11
MT
I
KVGINGFGRIGR
I
V
F
-
R
A
A
Q
--
K
RS
D
I
E
I
VAINDL
L
DA
DY
MAY
M
LKYDS
T
HGRF
D
G
T
V
EVKD
G
H
LIV
N
GK
K
IRV
T
AER
DPA
NL
K
W
D
E
V
GVDVV
A
E
A
TG
L
F
L
T
D
E
TA
R
K
HI
T
AGAKKV
V
M
T
G
P
-
S
K
D
NTP
M
F
V
K
G
A
N
F
D
K
Y
A
G
Q
D
-
IVSNASCTTNCLAP
L
AK
V
I
N
D
N
FGI
I
E
G
L
MTT
V
HA
T
T
A
TQ
KT
VDGP
S
HKD
W
R
GG
R
G
ASQNIIP
SS
TGAAKA
V
G
K
V
L
PELNGKL
T
G
M
A
F
RVPT
P
NVSV
V
DL
T
V
R
L
E
K
A
A
T
Y
E
QIK
A
A
V
K
A
AA
E
G
EMK
G
VL
GYTE
DD
V
VS
T
DFNG
EVCT
SVFDA
KA
G
--
I
A
L
N
D
-N
F
VK
L
V
S
WYDNE
T
G
Y
S
N
KV
LDLIAHISK
fig|656417.3.peg.2289
Escherichia coli M605
MT
I
KVGINGFGRIGR
I
V
F
-
R
A
A
Q
--
K
RS
D
I
E
I
VAINDL
L
DA
DY
MAY
M
LKYDS
T
HGRF
D
G
T
V
EVKD
G
H
LIV
N
GK
K
IRV
T
AER
DPA
NL
K
W
D
E
V
GVDVV
A
E
A
TG
L
F
L
T
D
E
TA
R
K
HI
T
AGAKKV
V
M
T
G
P
-
S
K
D
NTP
M
F
V
K
G
A
N
F
D
K
Y
A
G
Q
D
-
IVSNASCTTNCLAP
L
AK
V
I
N
D
N
FGI
I
E
G
L
MTT
V
HA
T
T
A
TQ
KT
VDGP
S
HKD
W
R
GG
R
G
ASQNIIP
SS
TGAAKA
V
G
K
V
L
PELNGKL
T
G
M
A
F
RVPT
P
NVSV
V
DL
T
V
R
L
E
K
A
A
T
Y
E
QIK
A
A
V
K
A
AA
E
G
EMK
G
VL
GYTE
DD
V
VS
T
DFNG
EVCT
SVFDA
KA
G
--
I
A
L
N
D
-N
F
VK
L
V
S
WYDNE
T
G
Y
S
N
KV
LDLIAHISK
fig|656419.3.peg.2498
Escherichia coli M718
MT
I
KVGINGFGRIGR
I
V
F
-
R
A
A
Q
--
K
RS
D
I
E
I
VAINDL
L
DA
DY
MAY
M
LKYDS
T
HGRF
D
G
T
V
EVKD
G
H
LIV
N
GK
K
IRV
T
AER
DPA
NL
K
W
D
E
V
GVDVV
A
E
A
TG
L
F
L
T
D
E
TA
R
K
HI
T
AGAKKV
V
M
T
G
P
-
S
K
D
NTP
M
F
V
K
G
A
N
F
D
K
Y
A
G
Q
D
-
IVSNASCTTNCLAP
L
AK
V
I
N
D
N
FGI
I
E
G
L
MTT
V
HA
T
T
A
TQ
KT
VDGP
S
HKD
W
R
GG
R
G
ASQNIIP
SS
TGAAKA
V
G
K
V
L
PELNGKL
T
G
M
A
F
RVPT
P
NVSV
V
DL
T
V
R
L
E
K
A
A
T
Y
E
QIK
A
A
V
K
A
AA
E
G
EMK
G
VL
GYTE
DD
V
VS
T
DFNG
EVCT
SVFDA
KA
G
--
I
A
L
N
D
-N
F
VK
L
V
S
WYDNE
T
G
Y
S
N
KV
LDLIAHISK
fig|679207.4.peg.3366
Escherichia coli MS 107-1
MT
I
KVGINGFGRIGR
I
V
F
-
R
A
A
Q
--
K
RS
D
I
E
I
VAINDL
L
DA
DY
MAY
M
LKYDS
T
HGRF
D
G
T
V
EVKD
G
H
LIV
N
GK
K
IRV
T
AER
DPA
NL
K
W
D
E
V
GVDVV
A
E
A
TG
L
F
L
T
D
E
TA
R
K
HI
T
AGAKKV
V
M
T
G
P
-
S
K
D
NTP
M
F
V
K
G
A
N
F
D
K
Y
A
G
Q
D
-
IVSNASCTTNCLAP
L
AK
V
I
N
D
N
FGI
I
E
G
L
MTT
V
HA
T
T
A
TQ
KT
VDGP
S
HKD
W
R
GG
R
G
ASQNIIP
SS
TGAAKA
V
G
K
V
L
PELNGKL
T
G
M
A
F
RVPT
P
NVSV
V
DL
T
V
R
L
E
K
A
A
T
Y
E
QIK
A
A
V
K
A
AA
E
G
EMK
G
VL
GYTE
DD
V
VS
T
DFNG
EVCT
SVFDA
KA
G
--
I
A
L
N
D
-N
F
VK
L
V
S
WYDNE
T
G
Y
S
N
KV
LDLIAHISK
fig|749537.3.peg.1405
Escherichia coli MS 115-1
MT
I
KVGINGFGRIGR
I
V
F
-
R
A
A
Q
--
K
RS
D
I
E
I
VAINDL
L
DA
DY
MAY
M
LKYDS
T
HGRF
D
G
T
V
EVKD
G
H
LIV
N
GK
K
IRV
T
AER
DPA
NL
K
W
D
E
V
GVDVV
A
E
A
TG
L
F
L
T
D
E
TA
R
K
HI
T
AGAKKV
V
M
T
G
P
-
S
K
D
NTP
M
F
V
K
G
A
N
F
D
K
Y
A
G
Q
D
-
IVSNASCTTNCLAP
L
AK
V
I
N
D
N
FGI
I
E
G
L
MTT
V
HA
T
T
A
TQ
KT
VDGP
S
HKD
W
R
GG
R
G
ASQNIIP
SS
TGAAKA
V
G
K
V
L
PELNGKL
T
G
M
A
F
RVPT
P
NVSV
V
DL
T
V
R
L
E
K
A
A
T
Y
E
QIK
A
A
V
K
A
AA
E
G
EMK
G
VL
GYTE
DD
V
VS
T
DFNG
EVCT
SVFDA
KA
G
--
I
A
L
N
D
-N
F
VK
L
V
S
WYDNE
T
G
Y
S
N
KV
LDLIAHISK
fig|749538.3.peg.4387
Escherichia coli MS 116-1
MT
I
KVGINGFGRIGR
I
V
F
-
R
A
A
Q
--
K
RS
D
I
E
I
VAINDL
L
DA
DY
MAY
M
LKYDS
T
HGRF
D
G
T
V
EVKD
G
H
LIV
N
GK
K
IRV
T
AER
DPA
NL
K
W
D
E
V
GVDVV
A
E
A
TG
L
F
L
T
D
E
TA
R
K
HI
T
AGAKKV
V
M
T
G
P
-
S
K
D
NTP
M
F
V
K
G
A
N
F
D
K
Y
A
G
Q
D
-
IVSNASCTTNCLAP
L
AK
V
I
N
D
N
FGI
I
E
G
L
MTT
V
HA
T
T
A
TQ
KT
VDGP
S
HKD
W
R
GG
R
G
ASQNIIP
SS
TGAAKA
V
G
K
V
L
PELNGKL
T
G
M
A
F
RVPT
P
NVSV
V
DL
T
V
R
L
E
K
A
A
T
Y
E
QIK
A
A
V
K
A
AA
E
G
EMK
G
VL
GYTE
DD
V
VS
T
DFNG
EVCT
SVFDA
KA
G
--
I
A
L
N
D
-N
F
VK
L
V
S
WYDNE
T
G
Y
S
N
KV
LDLIAHISK
fig|679206.4.peg.2953
Escherichia coli MS 119-7
MT
I
KVGINGFGRIGR
I
V
F
-
R
A
A
Q
--
K
RS
D
I
E
I
VAINDL
L
DA
DY
MAY
M
LKYDS
T
HGRF
D
G
T
V
EVKD
G
H
LIV
N
GK
K
IRV
T
AER
DPA
NL
K
W
D
E
V
GVDVV
A
E
A
TG
L
F
L
T
D
E
TA
R
K
HI
T
AGAKKV
V
M
T
G
P
-
S
K
D
NTP
M
F
V
K
G
A
N
F
D
K
Y
A
G
Q
D
-
IVSNASCTTNCLAP
L
AK
V
I
N
D
N
FGI
I
E
G
L
MTT
V
HA
T
T
A
TQ
KT
VDGP
S
HKD
W
R
GG
R
G
ASQNIIP
SS
TGAAKA
V
G
K
V
L
PELNGKL
T
G
M
A
F
RVPT
P
NVSV
V
DL
T
V
R
L
E
K
A
A
T
Y
E
QIK
A
A
V
K
A
AA
E
G
EMK
G
VL
GYTE
DD
V
VS
T
DFNG
EVCT
SVFDA
KA
G
--
I
A
L
N
D
-N
F
VK
L
V
S
WYDNE
T
G
Y
S
N
KV
LDLIAHISK
fig|679204.3.peg.703
Escherichia coli MS 145-7
MT
I
KVGINGFGRIGR
I
V
F
-
R
A
A
Q
--
K
RS
D
I
E
I
VAINDL
L
DA
DY
MAY
M
LKYDS
T
HGRF
D
G
T
V
EVKD
G
H
LIV
N
GK
K
IRV
T
AER
DPA
NL
K
W
D
E
V
GVDVV
A
E
A
TG
L
F
L
T
D
E
TA
R
K
HI
T
AGAKKV
V
M
T
G
P
-
S
K
D
NTP
M
F
V
K
G
A
N
F
D
K
Y
A
G
Q
D
-
IVSNASCTTNCLAP
L
AK
V
I
N
D
N
FGI
I
E
G
L
MTT
V
HA
T
T
A
TQ
KT
VDGP
S
HKD
W
R
GG
R
G
ASQNIIP
SS
TGAAKA
V
G
K
V
L
PELNGKL
T
G
M
A
F
RVPT
P
NVSV
V
DL
T
V
R
L
E
K
A
A
T
Y
E
QIK
A
A
V
K
A
AA
E
G
EMK
G
VL
GYTE
DD
V
VS
T
DFNG
EVCT
SVFDA
KA
G
--
I
A
L
N
D
-N
F
VK
L
V
S
WYDNE
T
G
Y
S
N
KV
LDLIAHISK
fig|749540.3.peg.4200
Escherichia coli MS 146-1
MT
I
KVGINGFGRIGR
I
V
F
-
R
A
A
Q
--
K
RS
D
I
E
I
VAINDL
L
DA
DY
MAY
M
LKYDS
T
HGRF
D
G
T
V
EVKD
G
H
LIV
N
GK
K
IRV
T
AER
DPA
NL
K
W
D
E
V
GVDVV
A
E
A
TG
L
F
L
T
D
E
TA
R
K
HI
T
AGAKKV
V
M
T
G
P
-
S
K
D
NTP
M
F
V
K
G
A
N
F
D
K
Y
A
G
Q
D
-
IVSNASCTTNCLAP
L
AK
V
I
N
D
N
FGI
I
E
G
L
MTT
V
HA
T
T
A
TQ
KT
VDGP
S
HKD
W
R
GG
R
G
ASQNIIP
SS
TGAAKA
V
G
K
V
L
PELNGKL
T
G
M
A
F
RVPT
P
NVSV
V
DL
T
V
R
L
E
K
A
A
T
Y
E
QIK
A
A
V
K
A
AA
E
G
EMK
G
VL
GYTE
DD
V
VS
T
DFNG
EVCT
SVFDA
KA
G
--
I
A
L
N
D
-N
F
VK
L
V
S
WYDNE
T
G
Y
S
N
KV
LDLIAHISK
fig|749545.3.peg.2713
Escherichia coli MS 182-1
MT
I
KVGINGFGRIGR
I
V
F
-
R
A
A
Q
--
K
RS
D
I
E
I
VAINDL
L
DA
DY
MAY
M
LKYDS
T
HGRF
D
G
T
V
EVKD
G
H
LIV
N
GK
K
IRV
T
AER
DPA
NL
K
W
D
E
V
GVDVV
A
E
A
TG
L
F
L
T
D
E
TA
R
K
HI
T
AGAKKV
V
M
T
G
P
-
S
K
D
NTP
M
F
V
K
G
A
N
F
D
K
Y
A
G
Q
D
-
IVSNASCTTNCLAP
L
AK
V
I
N
D
N
FGI
I
E
G
L
MTT
V
HA
T
T
A
TQ
KT
VDGP
S
HKD
W
R
GG
R
G
ASQNIIP
SS
TGAAKA
V
G
K
V
L
PELNGKL
T
G
M
A
F
RVPT
P
NVSV
V
DL
T
V
R
L
E
K
A
A
T
Y
E
QIK
A
A
V
K
A
AA
E
G
EMK
G
VL
GYTE
DD
V
VS
T
DFNG
EVCT
SVFDA
KA
G
--
I
A
L
N
D
-N
F
VK
L
V
S
WYDNE
T
G
Y
S
N
KV
LDLIAHISK
fig|749546.3.peg.4427
Escherichia coli MS 185-1
MT
I
KVGINGFGRIGR
I
V
F
-
R
A
A
Q
--
K
RS
D
I
E
I
VAINDL
L
DA
DY
MAY
M
LKYDS
T
HGRF
D
G
T
V
EVKD
G
H
LIV
N
GK
K
IRV
T
AER
DPA
NL
K
W
D
E
V
GVDVV
A
E
A
TG
L
F
L
T
D
E
TA
R
K
HI
T
AGAKKV
V
M
T
G
P
-
S
K
D
NTP
M
F
V
K
G
A
N
F
D
K
Y
A
G
Q
D
-
IVSNASCTTNCLAP
L
AK
V
I
N
D
N
FGI
I
E
G
L
MTT
V
HA
T
T
A
TQ
KT
VDGP
S
HKD
W
R
GG
R
G
ASQNIIP
SS
TGAAKA
V
G
K
V
L
PELNGKL
T
G
M
A
F
RVPT
P
NVSV
V
DL
T
V
R
L
E
K
A
A
T
Y
E
QIK
A
A
V
K
A
AA
E
G
EMK
G
VL
GYTE
DD
V
VS
T
DFNG
EVCT
SVFDA
KA
G
--
I
A
L
N
D
-N
F
VK
L
V
S
WYDNE
T
G
Y
S
N
KV
LDLIAHISK
fig|749547.3.peg.2899
Escherichia coli MS 187-1
MT
I
KVGINGFGRIGR
I
V
F
-
R
A
A
Q
--
K
RS
D
I
E
I
VAINDL
L
DA
DY
MAY
M
LKYDS
T
HGRF
D
G
T
V
EVKD
G
H
LIV
N
GK
K
IRV
T
AER
DPA
NL
K
W
D
E
V
GVDVV
A
E
A
TG
L
F
L
T
D
E
TA
R
K
HI
T
AGAKKV
V
M
T
G
P
-
S
K
D
NTP
M
F
V
K
G
A
N
F
D
K
Y
A
G
Q
D
-
IVSNASCTTNCLAP
L
AK
V
I
N
D
N
FGI
I
E
G
L
MTT
V
HA
T
T
A
TQ
KT
VDGP
S
HKD
W
R
GG
R
G
ASQNIIP
SS
TGAAKA
V
G
K
V
L
PELNGKL
T
G
M
A
F
RVPT
P
NVSV
V
DL
T
V
R
L
E
K
A
A
T
Y
E
QIK
A
A
V
K
A
AA
E
G
EMK
G
VL
GYTE
DD
V
VS
T
DFNG
EVCT
SVFDA
KA
G
--
I
A
L
N
D
-N
F
VK
L
V
S
WYDNE
T
G
Y
S
N
KV
LDLIAHISK
fig|749548.3.peg.960
Escherichia coli MS 196-1
MT
I
KVGINGFGRIGR
I
V
F
-
R
A
A
Q
--
K
RS
D
I
E
I
VAINDL
L
DA
DY
MAY
M
LKYDS
T
HGRF
D
G
T
V
EVKD
G
H
LIV
N
GK
K
IRV
T
AER
DPA
NL
K
W
D
E
V
GVDVV
A
E
A
TG
L
F
L
T
D
E
TA
R
K
HI
T
AGAKKV
V
M
T
G
P
-
S
K
D
NTP
M
F
V
K
G
A
N
F
D
K
Y
A
G
Q
D
-
IVSNASCTTNCLAP
L
AK
V
I
N
D
N
FGI
I
E
G
L
MTT
V
HA
T
T
A
TQ
KT
VDGP
S
HKD
W
R
GG
R
G
ASQNIIP
SS
TGAAKA
V
G
K
V
L
PELNGKL
T
G
M
A
F
RVPT
P
NVSV
V
DL
T
V
R
L
E
K
A
A
T
Y
E
QIK
A
A
V
K
A
AA
E
G
EMK
G
VL
GYTE
DD
V
VS
T
DFNG
EVCT
SVFDA
KA
G
--
I
A
L
N
D
-N
F
VK
L
V
S
WYDNE
T
G
Y
S
N
KV
LDLIAHISK
fig|749549.3.peg.3046
Escherichia coli MS 198-1
MT
I
KVGINGFGRIGR
I
V
F
-
R
A
A
Q
--
K
RS
D
I
E
I
VAINDL
L
DA
DY
MAY
M
LKYDS
T
HGRF
D
G
T
V
EVKD
G
H
LIV
N
GK
K
IRV
T
AER
DPA
NL
K
W
D
E
V
GVDVV
A
E
A
TG
L
F
L
T
D
E
TA
R
K
HI
T
AGAKKV
V
M
T
G
P
-
S
K
D
NTP
M
F
V
K
G
A
N
F
D
K
Y
A
G
Q
D
-
IVSNASCTTNCLAP
L
AK
V
I
N
D
N
FGI
I
E
G
L
MTT
V
HA
T
T
A
TQ
KT
VDGP
S
HKD
W
R
GG
R
G
ASQNIIP
SS
TGAAKA
V
G
K
V
L
PELNGKL
T
G
M
A
F
RVPT
P
NVSV
V
DL
T
V
R
L
E
K
A
A
T
Y
E
QIK
A
A
V
K
A
AA
E
G
EMK
G
VL
GYTE
DD
V
VS
T
DFNG
EVCT
SVFDA
KA
G
--
I
A
L
N
D
-N
F
VK
L
V
S
WYDNE
T
G
Y
S
N
KV
LDLIAHISK
fig|749550.3.peg.628
Escherichia coli MS 200-1
MT
I
KVGINGFGRIGR
I
V
F
-
R
A
A
Q
--
K
RS
D
I
E
I
VAINDL
L
DA
DY
MAY
M
LKYDS
T
HGRF
D
G
T
V
EVKD
G
H
LIV
N
GK
K
IRV
T
AER
DPA
NL
K
W
D
E
V
GVDVV
A
E
A
TG
L
F
L
T
D
E
TA
R
K
HI
T
AGAKKV
V
M
T
G
P
-
S
K
D
NTP
M
F
V
K
G
A
N
F
D
K
Y
A
G
Q
D
-
IVSNASCTTNCLAP
L
AK
V
I
N
D
N
FGI
I
E
G
L
MTT
V
HA
T
T
A
TQ
KT
VDGP
S
HKD
W
R
GG
R
G
ASQNIIP
SS
TGAAKA
V
G
K
V
L
PELNGKL
T
G
M
A
F
RVPT
P
NVSV
V
DL
T
V
R
L
E
K
A
A
T
Y
E
QIK
A
A
V
K
A
AA
E
G
EMK
G
VL
GYTE
DD
V
VS
T
DFNG
EVCT
SVFDA
KA
G
--
I
A
L
N
D
-N
F
VK
L
V
S
WYDNE
T
G
Y
S
N
KV
LDLIAHISK
fig|749527.3.peg.3650
Escherichia coli MS 21-1
MT
I
KVGINGFGRIGR
I
V
F
-
R
A
A
Q
--
K
RS
D
I
E
I
VAINDL
L
DA
DY
MAY
M
LKYDS
T
HGRF
D
G
T
V
EVKD
G
H
LIV
N
GK
K
IRV
T
AER
DPA
NL
K
W
D
E
V
GVDVV
A
E
A
TG
L
F
L
T
D
E
TA
R
K
HI
T
AGAKKV
V
M
T
G
P
-
S
K
D
NTP
M
F
V
K
G
A
N
F
D
K
Y
A
G
Q
D
-
IVSNASCTTNCLAP
L
AK
V
I
N
D
N
FGI
I
E
G
L
MTT
V
HA
T
T
A
TQ
KT
VDGP
S
HKD
W
R
GG
R
G
ASQNIIP
SS
TGAAKA
V
G
K
V
L
PELNGKL
T
G
M
A
F
RVPT
P
NVSV
V
DL
T
V
R
L
E
K
A
A
T
Y
E
QIK
A
A
V
K
A
AA
E
G
EMK
G
VL
GYTE
DD
V
VS
T
DFNG
EVCT
SVFDA
KA
G
--
I
A
L
N
D
-N
F
VK
L
V
S
WYDNE
T
G
Y
S
N
KV
LDLIAHISK
fig|749528.3.peg.4749
Escherichia coli MS 45-1
MT
I
KVGINGFGRIGR
I
V
F
-
R
A
A
Q
--
K
RS
D
I
E
I
VAINDL
L
DA
DY
MAY
M
LKYDS
T
HGRF
D
G
T
V
EVKD
G
H
LIV
N
GK
K
IRV
T
AER
DPA
NL
K
W
D
E
V
GVDVV
A
E
A
TG
L
F
L
T
D
E
TA
R
K
HI
T
AGAKKV
V
M
T
G
P
-
S
K
D
NTP
M
F
V
K
G
A
N
F
D
K
Y
A
G
Q
D
-
IVSNASCTTNCLAP
L
AK
V
I
N
D
N
FGI
I
E
G
L
MTT
V
HA
T
T
A
TQ
KT
VDGP
S
HKD
W
R
GG
R
G
ASQNIIP
SS
TGAAKA
V
G
K
V
L
PELNGKL
T
G
M
A
F
RVPT
P
NVSV
V
DL
T
V
R
L
E
K
A
A
T
Y
E
QIK
A
A
V
K
A
AA
E
G
EMK
G
VL
GYTE
DD
V
VS
T
DFNG
EVCT
SVFDA
KA
G
--
I
A
L
N
D
-N
F
VK
L
V
S
WYDNE
T
G
Y
S
N
KV
LDLIAHISK
fig|749531.3.peg.4689
Escherichia coli MS 69-1
MT
I
KVGINGFGRIGR
I
V
F
-
R
A
A
Q
--
K
RS
D
I
E
I
VAINDL
L
DA
DY
MAY
M
LKYDS
T
HGRF
D
G
T
V
EVKD
G
H
LIV
N
GK
K
IRV
T
AER
DPA
NL
K
W
D
E
V
GVDVV
A
E
A
TG
L
F
L
T
D
E
TA
R
K
HI
T
AGAKKV
V
M
T
G
P
-
S
K
D
NTP
M
F
V
K
G
A
N
F
D
K
Y
A
G
Q
D
-
IVSNASCTTNCLAP
L
AK
V
I
N
D
N
FGI
I
E
G
L
MTT
V
HA
T
T
A
TQ
KT
VDGP
S
HKD
W
R
GG
R
G
ASQNIIP
SS
TGAAKA
V
G
K
V
L
PELNGKL
T
G
M
A
F
RVPT
P
NVSV
V
DL
T
V
R
L
E
K
A
A
T
Y
E
QIK
A
A
V
K
A
AA
E
G
EMK
G
VL
GYTE
DD
V
VS
T
DFNG
EVCT
SVFDA
KA
G
--
I
A
L
N
D
-N
F
VK
L
V
S
WYDNE
T
G
Y
S
N
KV
LDLIAHISK
fig|749532.3.peg.2271
Escherichia coli MS 78-1
MT
I
KVGINGFGRIGR
I
V
F
-
R
A
A
Q
--
K
RS
D
I
E
I
VAINDL
L
DA
DY
MAY
M
LKYDS
T
HGRF
D
G
T
V
EVKD
G
H
LIV
N
GK
K
IRV
T
AER
DPA
NL
K
W
D
E
V
GVDVV
A
E
A
TG
L
F
L
T
D
E
TA
R
K
HI
T
AGAKKV
V
M
T
G
P
-
S
K
D
NTP
M
F
V
K
G
A
N
F
D
K
Y
A
G
Q
D
-
IVSNASCTTNCLAP
L
AK
V
I
N
D
N
FGI
I
E
G
L
MTT
V
HA
T
T
A
TQ
KT
VDGP
S
HKD
W
R
GG
R
G
ASQNIIP
SS
TGAAKA
V
G
K
V
L
PELNGKL
T
G
M
A
F
RVPT
P
NVSV
V
DL
T
V
R
L
E
K
A
A
T
Y
E
QIK
A
A
V
K
A
AA
E
G
EMK
G
VL
GYTE
DD
V
VS
T
DFNG
EVCT
SVFDA
KA
G
--
I
A
L
N
D
-N
F
VK
L
V
S
WYDNE
T
G
Y
S
N
KV
LDLIAHISK
fig|753642.3.peg.3181
Escherichia coli NC101
MT
I
KVGINGFGRIGR
I
V
F
-
R
A
A
Q
--
K
RS
D
I
E
I
VAINDL
L
DA
DY
MAY
M
LKYDS
T
HGRF
D
G
T
V
EVKD
G
H
LIV
N
GK
K
IRV
T
AER
DPA
NL
K
W
D
E
V
GVDVV
A
E
A
TG
L
F
L
T
D
E
TA
R
K
HI
T
AGAKKV
V
M
T
G
P
-
S
K
D
NTP
M
F
V
K
G
A
N
F
D
K
Y
A
G
Q
D
-
IVSNASCTTNCLAP
L
AK
V
I
N
D
N
FGI
I
E
G
L
MTT
V
HA
T
T
A
TQ
KT
VDGP
S
HKD
W
R
GG
R
G
ASQNIIP
SS
TGAAKA
V
G
K
V
L
PELNGKL
T
G
M
A
F
RVPT
P
NVSV
V
DL
T
V
R
L
E
K
A
A
T
Y
E
QIK
A
A
V
K
A
AA
E
G
EMK
G
VL
GYTE
DD
V
VS
T
DFNG
EVCT
SVFDA
KA
G
--
I
A
L
N
D
-N
F
VK
L
V
S
WYDNE
T
G
Y
S
N
KV
LDLIAHISK
fig|585395.4.peg.2060
Escherichia coli O103:H2 str. 12009
MT
I
KVGINGFGRIGR
I
V
F
-
R
A
A
Q
--
K
RS
D
I
E
I
VAINDL
L
DA
DY
MAY
M
LKYDS
T
HGRF
D
G
T
V
EVKD
G
H
LIV
N
GK
K
IRV
T
AER
DPA
NL
K
W
D
E
V
GVDVV
A
E
A
TG
L
F
L
T
D
E
TA
R
K
HI
T
AGAKKV
V
M
T
G
P
-
S
K
D
NTP
M
F
V
K
G
A
N
F
D
K
Y
A
G
Q
D
-
IVSNASCTTNCLAP
L
AK
V
I
N
D
N
FGI
I
E
G
L
MTT
V
HA
T
T
A
TQ
KT
VDGP
S
HKD
W
R
GG
R
G
ASQNIIP
SS
TGAAKA
V
G
K
V
L
PELNGKL
T
G
M
A
F
RVPT
P
NVSV
V
DL
T
V
R
L
E
K
A
A
T
Y
E
QIK
A
A
V
K
A
AA
E
G
EMK
G
VL
GYTE
DD
V
VS
T
DFNG
EVCT
SVFDA
KA
G
--
I
A
L
N
D
-N
F
VK
L
V
S
WYDNE
T
G
Y
S
N
KV
LDLIAHISK
fig|585396.4.peg.2368
Escherichia coli O111:H- str. 11128
MT
I
KVGINGFGRIGR
I
V
F
-
R
A
A
Q
--
K
RS
D
I
E
I
VAINDL
L
DA
DY
MAY
M
LKYDS
T
HGRF
D
G
T
V
EVKD
G
H
LIV
N
GK
K
IRV
T
AER
DPA
NL
K
W
D
E
V
GVDVV
A
E
A
TG
L
F
L
T
D
E
TA
R
K
HI
T
AGAKKV
V
M
T
G
P
-
S
K
D
NTP
M
F
V
K
G
A
N
F
D
K
Y
A
G
Q
D
-
IVSNASCTTNCLAP
L
AK
V
I
N
D
N
FGI
I
E
G
L
MTT
V
HA
T
T
A
TQ
KT
VDGP
S
HKD
W
R
GG
R
G
ASQNIIP
SS
TGAAKA
V
G
K
V
L
PELNGKL
T
G
M
A
F
RVPT
P
NVSV
V
DL
T
V
R
L
E
K
A
A
T
Y
E
QIK
A
A
V
K
A
AA
E
G
EMK
G
VL
GYTE
DD
V
VS
T
DFNG
EVCT
SVFDA
KA
G
--
I
A
L
N
D
-N
F
VK
L
V
S
WYDNE
T
G
Y
S
N
KV
LDLIAHISK
fig|574521.7.peg.1951
Escherichia coli O127:H6 str. E2348/69
MT
I
KVGINGFGRIGR
I
V
F
-
R
A
A
Q
--
K
RS
D
I
E
I
VAINDL
L
DA
DY
MAY
M
LKYDS
T
HGRF
D
G
T
V
EVKD
G
H
LIV
N
GK
K
IRV
T
AER
DPA
NL
K
W
D
E
V
GVDVV
A
E
A
TG
L
F
L
T
D
E
TA
R
K
HI
T
AGAKKV
V
M
T
G
P
-
S
K
D
NTP
M
F
V
K
G
A
N
F
D
K
Y
A
G
Q
D
-
IVSNASCTTNCLAP
L
AK
V
I
N
D
N
FGI
I
E
G
L
MTT
V
HA
T
T
A
TQ
KT
VDGP
S
HKD
W
R
GG
R
G
ASQNIIP
SS
TGAAKA
V
G
K
V
L
PELNGKL
T
G
M
A
F
RVPT
P
NVSV
V
DL
T
V
R
L
E
K
A
A
T
Y
E
QIK
A
A
V
K
A
AA
E
G
EMK
G
VL
GYTE
DD
V
VS
T
DFNG
EVCT
SVFDA
KA
G
--
I
A
L
N
D
-N
F
VK
L
V
S
WYDNE
T
G
Y
S
N
KV
LDLIAHISK
fig|83334.1.peg.2514
Escherichia coli O157:H7
MT
I
KVGINGFGRIGR
I
V
F
-
R
A
A
Q
--
K
RS
D
I
E
I
VAINDL
L
DA
DY
MAY
M
LKYDS
T
HGRF
D
G
T
V
EVKD
G
H
LIV
N
GK
K
IRV
T
AER
DPA
NL
K
W
D
E
V
GVDVV
A
E
A
TG
L
F
L
T
D
E
TA
R
K
HI
T
AGAKKV
V
M
T
G
P
-
S
K
D
NTP
M
F
V
K
G
A
N
F
D
K
Y
A
G
Q
D
-
IVSNASCTTNCLAP
L
AK
V
I
N
D
N
FGI
I
E
G
L
MTT
V
HA
T
T
A
TQ
KT
VDGP
S
HKD
W
R
GG
R
G
ASQNIIP
SS
TGAAKA
V
G
K
V
L
PELNGKL
T
G
M
A
F
RVPT
P
NVSV
V
DL
T
V
R
L
E
K
A
A
T
Y
E
QIK
A
A
V
K
A
AA
E
G
EMK
G
VL
GYTE
DD
V
VS
T
DFNG
EVCT
SVFDA
KA
G
--
I
A
L
N
D
-N
F
VK
L
V
S
WYDNE
T
G
Y
S
N
KV
LDLIAHISK
fig|155864.1.peg.2523
Escherichia coli O157:H7 EDL933
MT
I
KVGINGFGRIGR
I
V
F
-
R
A
A
Q
--
K
RS
D
I
E
I
VAINDL
L
DA
DY
MAY
M
LKYDS
T
HGRF
D
G
T
V
EVKD
G
H
LIV
N
GK
K
IRV
T
AER
DPA
NL
K
W
D
E
V
GVDVV
A
E
A
TG
L
F
L
T
D
E
TA
R
K
HI
T
AGAKKV
V
M
T
G
P
-
S
K
D
NTP
M
F
V
K
G
A
N
F
D
K
Y
A
G
Q
D
-
IVSNASCTTNCLAP
L
AK
V
I
N
D
N
FGI
I
E
G
L
MTT
V
HA
T
T
A
TQ
KT
VDGP
S
HKD
W
R
GG
R
G
ASQNIIP
SS
TGAAKA
V
G
K
V
L
PELNGKL
T
G
M
A
F
RVPT
P
NVSV
V
DL
T
V
R
L
E
K
A
A
T
Y
E
QIK
A
A
V
K
A
AA
E
G
EMK
G
VL
GYTE
DD
V
VS
T
DFNG
EVCT
SVFDA
KA
G
--
I
A
L
N
D
-N
F
VK
L
V
S
WYDNE
T
G
Y
S
N
KV
LDLIAHISK
fig|155864.8.peg.2377
Escherichia coli O157:H7 EDL933
MT
I
KVGINGFGRIGR
I
V
F
-
R
A
A
Q
--
K
RS
D
I
E
I
VAINDL
L
DA
DY
MAY
M
LKYDS
T
HGRF
D
G
T
V
EVKD
G
H
LIV
N
GK
K
IRV
T
AER
DPA
NL
K
W
D
E
V
GVDVV
A
E
A
TG
L
F
L
T
D
E
TA
R
K
HI
T
AGAKKV
V
M
T
G
P
-
S
K
D
NTP
M
F
V
K
G
A
N
F
D
K
Y
A
G
Q
D
-
IVSNASCTTNCLAP
L
AK
V
I
N
D
N
FGI
I
E
G
L
MTT
V
HA
T
T
A
TQ
KT
VDGP
S
HKD
W
R
GG
R
G
ASQNIIP
SS
TGAAKA
V
G
K
V
L
PELNGKL
T
G
M
A
F
RVPT
P
NVSV
V
DL
T
V
R
L
E
K
A
A
T
Y
E
QIK
A
A
V
K
A
AA
E
G
EMK
G
VL
GYTE
DD
V
VS
T
DFNG
EVCT
SVFDA
KA
G
--
I
A
L
N
D
-N
F
VK
L
V
S
WYDNE
T
G
Y
S
N
KV
LDLIAHISK
fig|444454.5.peg.1241
Escherichia coli O157:H7 str. EC4024
MT
I
KVGINGFGRIGR
I
V
F
-
R
A
A
Q
--
K
RS
D
I
E
I
VAINDL
L
DA
DY
MAY
M
LKYDS
T
HGRF
D
G
T
V
EVKD
G
H
LIV
N
GK
K
IRV
T
AER
DPA
NL
K
W
D
E
V
GVDVV
A
E
A
TG
L
F
L
T
D
E
TA
R
K
HI
T
AGAKKV
V
M
T
G
P
-
S
K
D
NTP
M
F
V
K
G
A
N
F
D
K
Y
A
G
Q
D
-
IVSNASCTTNCLAP
L
AK
V
I
N
D
N
FGI
I
E
G
L
MTT
V
HA
T
T
A
TQ
KT
VDGP
S
HKD
W
R
GG
R
G
ASQNIIP
SS
TGAAKA
V
G
K
V
L
PELNGKL
T
G
M
A
F
RVPT
P
NVSV
V
DL
T
V
R
L
E
K
A
A
T
Y
E
QIK
A
A
V
K
A
AA
E
G
EMK
G
VL
GYTE
DD
V
VS
T
DFNG
EVCT
SVFDA
KA
G
--
I
A
L
N
D
-N
F
VK
L
V
S
WYDNE
T
G
Y
S
N
KV
LDLIAHISK
fig|444449.5.peg.730
Escherichia coli O157:H7 str. EC4042
MT
I
KVGINGFGRIGR
I
V
F
-
R
A
A
Q
--
K
RS
D
I
E
I
VAINDL
L
DA
DY
MAY
M
LKYDS
T
HGRF
D
G
T
V
EVKD
G
H
LIV
N
GK
K
IRV
T
AER
DPA
NL
K
W
D
E
V
GVDVV
A
E
A
TG
L
F
L
T
D
E
TA
R
K
HI
T
AGAKKV
V
M
T
G
P
-
S
K
D
NTP
M
F
V
K
G
A
N
F
D
K
Y
A
G
Q
D
-
IVSNASCTTNCLAP
L
AK
V
I
N
D
N
FGI
I
E
G
L
MTT
V
HA
T
T
A
TQ
KT
VDGP
S
HKD
W
R
GG
R
G
ASQNIIP
SS
TGAAKA
V
G
K
V
L
PELNGKL
T
G
M
A
F
RVPT
P
NVSV
V
DL
T
V
R
L
E
K
A
A
T
Y
E
QIK
A
A
V
K
A
AA
E
G
EMK
G
VL
GYTE
DD
V
VS
T
DFNG
EVCT
SVFDA
KA
G
--
I
A
L
N
D
-N
F
VK
L
V
S
WYDNE
T
G
Y
S
N
KV
LDLIAHISK
fig|444448.5.peg.5031
Escherichia coli O157:H7 str. EC4045
MT
I
KVGINGFGRIGR
I
V
F
-
R
A
A
Q
--
K
RS
D
I
E
I
VAINDL
L
DA
DY
MAY
M
LKYDS
T
HGRF
D
G
T
V
EVKD
G
H
LIV
N
GK
K
IRV
T
AER
DPA
NL
K
W
D
E
V
GVDVV
A
E
A
TG
L
F
L
T
D
E
TA
R
K
HI
T
AGAKKV
V
M
T
G
P
-
S
K
D
NTP
M
F
V
K
G
A
N
F
D
K
Y
A
G
Q
D
-
IVSNASCTTNCLAP
L
AK
V
I
N
D
N
FGI
I
E
G
L
MTT
V
HA
T
T
A
TQ
KT
VDGP
S
HKD
W
R
GG
R
G
ASQNIIP
SS
TGAAKA
V
G
K
V
L
PELNGKL
T
G
M
A
F
RVPT
P
NVSV
V
DL
T
V
R
L
E
K
A
A
T
Y
E
QIK
A
A
V
K
A
AA
E
G
EMK
G
VL
GYTE
DD
V
VS
T
DFNG
EVCT
SVFDA
KA
G
--
I
A
L
N
D
-N
F
VK
L
V
S
WYDNE
T
G
Y
S
N
KV
LDLIAHISK
fig|444453.5.peg.3586
Escherichia coli O157:H7 str. EC4076
MT
I
KVGINGFGRIGR
I
V
F
-
R
A
A
Q
--
K
RS
D
I
E
I
VAINDL
L
DA
DY
MAY
M
LKYDS
T
HGRF
D
G
T
V
EVKD
G
H
LIV
N
GK
K
IRV
T
AER
DPA
NL
K
W
D
E
V
GVDVV
A
E
A
TG
L
F
L
T
D
E
TA
R
K
HI
T
AGAKKV
V
M
T
G
P
-
S
K
D
NTP
M
F
V
K
G
A
N
F
D
K
Y
A
G
Q
D
-
IVSNASCTTNCLAP
L
AK
V
I
N
D
N
FGI
I
E
G
L
MTT
V
HA
T
T
A
TQ
KT
VDGP
S
HKD
W
R
GG
R
G
ASQNIIP
SS
TGAAKA
V
G
K
V
L
PELNGKL
T
G
M
A
F
RVPT
P
NVSV
V
DL
T
V
R
L
E
K
A
A
T
Y
E
QIK
A
A
V
K
A
AA
E
G
EMK
G
VL
GYTE
DD
V
VS
T
DFNG
EVCT
SVFDA
KA
G
--
I
A
L
N
D
-N
F
VK
L
V
S
WYDNE
T
G
Y
S
N
KV
LDLIAHISK
fig|444452.5.peg.2402
Escherichia coli O157:H7 str. EC4113
MT
I
KVGINGFGRIGR
I
V
F
-
R
A
A
Q
--
K
RS
D
I
E
I
VAINDL
L
DA
DY
MAY
M
LKYDS
T
HGRF
D
G
T
V
EVKD
G
H
LIV
N
GK
K
IRV
T
AER
DPA
NL
K
W
D
E
V
GVDVV
A
E
A
TG
L
F
L
T
D
E
TA
R
K
HI
T
AGAKKV
V
M
T
G
P
-
S
K
D
NTP
M
F
V
K
G
A
N
F
D
K
Y
A
G
Q
D
-
IVSNASCTTNCLAP
L
AK
V
I
N
D
N
FGI
I
E
G
L
MTT
V
HA
T
T
A
TQ
KT
VDGP
S
HKD
W
R
GG
R
G
ASQNIIP
SS
TGAAKA
V
G
K
V
L
PELNGKL
T
G
M
A
F
RVPT
P
NVSV
V
DL
T
V
R
L
E
K
A
A
T
Y
E
QIK
A
A
V
K
A
AA
E
G
EMK
G
VL
GYTE
DD
V
VS
T
DFNG
EVCT
SVFDA
KA
G
--
I
A
L
N
D
-N
F
VK
L
V
S
WYDNE
T
G
Y
S
N
KV
LDLIAHISK
fig|444450.8.peg.2542
Escherichia coli O157:H7 str. EC4115
MT
I
KVGINGFGRIGR
I
V
F
-
R
A
A
Q
--
K
RS
D
I
E
I
VAINDL
L
DA
DY
MAY
M
LKYDS
T
HGRF
D
G
T
V
EVKD
G
H
LIV
N
GK
K
IRV
T
AER
DPA
NL
K
W
D
E
V
GVDVV
A
E
A
TG
L
F
L
T
D
E
TA
R
K
HI
T
AGAKKV
V
M
T
G
P
-
S
K
D
NTP
M
F
V
K
G
A
N
F
D
K
Y
A
G
Q
D
-
IVSNASCTTNCLAP
L
AK
V
I
N
D
N
FGI
I
E
G
L
MTT
V
HA
T
T
A
TQ
KT
VDGP
S
HKD
W
R
GG
R
G
ASQNIIP
SS
TGAAKA
V
G
K
V
L
PELNGKL
T
G
M
A
F
RVPT
P
NVSV
V
DL
T
V
R
L
E
K
A
A
T
Y
E
QIK
A
A
V
K
A
AA
E
G
EMK
G
VL
GYTE
DD
V
VS
T
DFNG
EVCT
SVFDA
KA
G
--
I
A
L
N
D
-N
F
VK
L
V
S
WYDNE
T
G
Y
S
N
KV
LDLIAHISK
fig|444451.5.peg.2540
Escherichia coli O157:H7 str. EC4196
MT
I
KVGINGFGRIGR
I
V
F
-
R
A
A
Q
--
K
RS
D
I
E
I
VAINDL
L
DA
DY
MAY
M
LKYDS
T
HGRF
D
G
T
V
EVKD
G
H
LIV
N
GK
K
IRV
T
AER
DPA
NL
K
W
D
E
V
GVDVV
A
E
A
TG
L
F
L
T
D
E
TA
R
K
HI
T
AGAKKV
V
M
T
G
P
-
S
K
D
NTP
M
F
V
K
G
A
N
F
D
K
Y
A
G
Q
D
-
IVSNASCTTNCLAP
L
AK
V
I
N
D
N
FGI
I
E
G
L
MTT
V
HA
T
T
A
TQ
KT
VDGP
S
HKD
W
R
GG
R
G
ASQNIIP
SS
TGAAKA
V
G
K
V
L
PELNGKL
T
G
M
A
F
RVPT
P
NVSV
V
DL
T
V
R
L
E
K
A
A
T
Y
E
QIK
A
A
V
K
A
AA
E
G
EMK
G
VL
GYTE
DD
V
VS
T
DFNG
EVCT
SVFDA
KA
G
--
I
A
L
N
D
-N
F
VK
L
V
S
WYDNE
T
G
Y
S
N
KV
LDLIAHISK
fig|444447.5.peg.4956
Escherichia coli O157:H7 str. EC4206
MT
I
KVGINGFGRIGR
I
V
F
-
R
A
A
Q
--
K
RS
D
I
E
I
VAINDL
L
DA
DY
MAY
M
LKYDS
T
HGRF
D
G
T
V
EVKD
G
H
LIV
N
GK
K
IRV
T
AER
DPA
NL
K
W
D
E
V
GVDVV
A
E
A
TG
L
F
L
T
D
E
TA
R
K
HI
T
AGAKKV
V
M
T
G
P
-
S
K
D
NTP
M
F
V
K
G
A
N
F
D
K
Y
A
G
Q
D
-
IVSNASCTTNCLAP
L
AK
V
I
N
D
N
FGI
I
E
G
L
MTT
V
HA
T
T
A
TQ
KT
VDGP
S
HKD
W
R
GG
R
G
ASQNIIP
SS
TGAAKA
V
G
K
V
L
PELNGKL
T
G
M
A
F
RVPT
P
NVSV
V
DL
T
V
R
L
E
K
A
A
T
Y
E
QIK
A
A
V
K
A
AA
E
G
EMK
G
VL
GYTE
DD
V
VS
T
DFNG
EVCT
SVFDA
KA
G
--
I
A
L
N
D
-N
F
VK
L
V
S
WYDNE
T
G
Y
S
N
KV
LDLIAHISK
fig|478004.5.peg.4690
Escherichia coli O157:H7 str. EC4401
MT
I
KVGINGFGRIGR
I
V
F
-
R
A
A
Q
--
K
RS
D
I
E
I
VAINDL
L
DA
DY
MAY
M
LKYDS
T
HGRF
D
G
T
V
EVKD
G
H
LIV
N
GK
K
IRV
T
AER
DPA
NL
K
W
D
E
V
GVDVV
A
E
A
TG
L
F
L
T
D
E
TA
R
K
HI
T
AGAKKV
V
M
T
G
P
-
S
K
D
NTP
M
F
V
K
G
A
N
F
D
K
Y
A
G
Q
D
-
IVSNASCTTNCLAP
L
AK
V
I
N
D
N
FGI
I
E
G
L
MTT
V
HA
T
T
A
TQ
KT
VDGP
S
HKD
W
R
GG
R
G
ASQNIIP
SS
TGAAKA
V
G
K
V
L
PELNGKL
T
G
M
A
F
RVPT
P
NVSV
V
DL
T
V
R
L
E
K
A
A
T
Y
E
QIK
A
A
V
K
A
AA
E
G
EMK
G
VL
GYTE
DD
V
VS
T
DFNG
EVCT
SVFDA
KA
G
--
I
A
L
N
D
-N
F
VK
L
V
S
WYDNE
T
G
Y
S
N
KV
LDLIAHISK
fig|478005.5.peg.4468
Escherichia coli O157:H7 str. EC4486
MT
I
KVGINGFGRIGR
I
V
F
-
R
A
A
Q
--
K
RS
D
I
E
I
VAINDL
L
DA
DY
MAY
M
LKYDS
T
HGRF
D
G
T
V
EVKD
G
H
LIV
N
GK
K
IRV
T
AER
DPA
NL
K
W
D
E
V
GVDVV
A
E
A
TG
L
F
L
T
D
E
TA
R
K
HI
T
AGAKKV
V
M
T
G
P
-
S
K
D
NTP
M
F
V
K
G
A
N
F
D
K
Y
A
G
Q
D
-
IVSNASCTTNCLAP
L
AK
V
I
N
D
N
FGI
I
E
G
L
MTT
V
HA
T
T
A
TQ
KT
VDGP
S
HKD
W
R
GG
R
G
ASQNIIP
SS
TGAAKA
V
G
K
V
L
PELNGKL
T
G
M
A
F
RVPT
P
NVSV
V
DL
T
V
R
L
E
K
A
A
T
Y
E
QIK
A
A
V
K
A
AA
E
G
EMK
G
VL
GYTE
DD
V
VS
T
DFNG
EVCT
SVFDA
KA
G
--
I
A
L
N
D
-N
F
VK
L
V
S
WYDNE
T
G
Y
S
N
KV
LDLIAHISK
fig|478007.5.peg.3706
Escherichia coli O157:H7 str. EC508
MT
I
KVGINGFGRIGR
I
V
F
-
R
A
A
Q
--
K
RS
D
I
E
I
VAINDL
L
DA
DY
MAY
M
LKYDS
T
HGRF
D
G
T
V
EVKD
G
H
LIV
N
GK
K
IRV
T
AER
DPA
NL
K
W
D
E
V
GVDVV
A
E
A
TG
L
F
L
T
D
E
TA
R
K
HI
T
AGAKKV
V
M
T
G
P
-
S
K
D
NTP
M
F
V
K
G
A
N
F
D
K
Y
A
G
Q
D
-
IVSNASCTTNCLAP
L
AK
V
I
N
D
N
FGI
I
E
G
L
MTT
V
HA
T
T
A
TQ
KT
VDGP
S
HKD
W
R
GG
R
G
ASQNIIP
SS
TGAAKA
V
G
K
V
L
PELNGKL
T
G
M
A
F
RVPT
P
NVSV
V
DL
T
V
R
L
E
K
A
A
T
Y
E
QIK
A
A
V
K
A
AA
E
G
EMK
G
VL
GYTE
DD
V
VS
T
DFNG
EVCT
SVFDA
KA
G
--
I
A
L
N
D
-N
F
VK
L
V
S
WYDNE
T
G
Y
S
N
KV
LDLIAHISK
fig|478008.5.peg.3382
Escherichia coli O157:H7 str. EC869
MT
I
KVGINGFGRIGR
I
V
F
-
R
A
A
Q
--
K
RS
D
I
E
I
VAINDL
L
DA
DY
MAY
M
LKYDS
T
HGRF
D
G
T
V
EVKD
G
H
LIV
N
GK
K
IRV
T
AER
DPA
NL
K
W
D
E
V
GVDVV
A
E
A
TG
L
F
L
T
D
E
TA
R
K
HI
T
AGAKKV
V
M
T
G
P
-
S
K
D
NTP
M
F
V
K
G
A
N
F
D
K
Y
A
G
Q
D
-
IVSNASCTTNCLAP
L
AK
V
I
N
D
N
FGI
I
E
G
L
MTT
V
HA
T
T
A
TQ
KT
VDGP
S
HKD
W
R
GG
R
G
ASQNIIP
SS
TGAAKA
V
G
K
V
L
PELNGKL
T
G
M
A
F
RVPT
P
NVSV
V
DL
T
V
R
L
E
K
A
A
T
Y
E
QIK
A
A
V
K
A
AA
E
G
EMK
G
VL
GYTE
DD
V
VS
T
DFNG
EVCT
SVFDA
KA
G
--
I
A
L
N
D
-N
F
VK
L
V
S
WYDNE
T
G
Y
S
N
KV
LDLIAHISK
fig|637388.3.peg.4809
Escherichia coli O157:H7 str. FRIK2000
MT
I
KVGINGFGRIGR
I
V
F
-
R
A
A
Q
--
K
RS
D
I
E
I
VAINDL
L
DA
DY
MAY
M
LKYDS
T
HGRF
D
G
T
V
EVKD
G
H
LIV
N
GK
K
IRV
T
AER
DPA
NL
K
W
D
E
V
GVDVV
A
E
A
TG
L
F
L
T
D
E
TA
R
K
HI
T
AGAKKV
V
M
T
G
P
-
S
K
D
NTP
M
F
V
K
G
A
N
F
D
K
Y
A
G
Q
D
-
IVSNASCTTNCLAP
L
AK
V
I
N
D
N
FGI
I
E
G
L
MTT
V
HA
T
T
A
TQ
KT
VDGP
S
HKD
W
R
GG
R
G
ASQNIIP
SS
TGAAKA
V
G
K
V
L
PELNGKL
T
G
M
A
F
RVPT
P
NVSV
V
DL
T
V
R
L
E
K
A
A
T
Y
E
QIK
A
A
V
K
A
AA
E
G
EMK
G
VL
GYTE
DD
V
VS
T
DFNG
EVCT
SVFDA
KA
G
--
I
A
L
N
D
-N
F
VK
L
V
S
WYDNE
T
G
Y
S
N
KV
LDLIAHISK
fig|570506.3.peg.3995
Escherichia coli O157:H7 str. FRIK966
MT
I
KVGINGFGRIGR
I
V
F
-
R
A
A
Q
--
K
RS
D
I
E
I
VAINDL
L
DA
DY
MAY
M
LKYDS
T
HGRF
D
G
T
V
EVKD
G
H
LIV
N
GK
K
IRV
T
AER
DPA
NL
K
W
D
E
V
GVDVV
A
E
A
TG
L
F
L
T
D
E
TA
R
K
HI
T
AGAKKV
V
M
T
G
P
-
S
K
D
NTP
M
F
V
K
G
A
N
F
D
K
Y
A
G
Q
D
-
IVSNASCTTNCLAP
L
AK
V
I
N
D
N
FGI
I
E
G
L
MTT
V
HA
T
T
A
TQ
KT
VDGP
S
HKD
W
R
GG
R
G
ASQNIIP
SS
TGAAKA
V
G
K
V
L
PELNGKL
T
G
M
A
F
RVPT
P
NVSV
V
DL
T
V
R
L
E
K
A
A
T
Y
E
QIK
A
A
V
K
A
AA
E
G
EMK
G
VL
GYTE
DD
V
VS
T
DFNG
EVCT
SVFDA
KA
G
--
I
A
L
N
D
-N
F
VK
L
V
S
WYDNE
T
G
Y
S
N
KV
LDLIAHISK
fig|386585.9.peg.2605
Escherichia coli O157:H7 str. Sakai
MT
I
KVGINGFGRIGR
I
V
F
-
R
A
A
Q
--
K
RS
D
I
E
I
VAINDL
L
DA
DY
MAY
M
LKYDS
T
HGRF
D
G
T
V
EVKD
G
H
LIV
N
GK
K
IRV
T
AER
DPA
NL
K
W
D
E
V
GVDVV
A
E
A
TG
L
F
L
T
D
E
TA
R
K
HI
T
AGAKKV
V
M
T
G
P
-
S
K
D
NTP
M
F
V
K
G
A
N
F
D
K
Y
A
G
Q
D
-
IVSNASCTTNCLAP
L
AK
V
I
N
D
N
FGI
I
E
G
L
MTT
V
HA
T
T
A
TQ
KT
VDGP
S
HKD
W
R
GG
R
G
ASQNIIP
SS
TGAAKA
V
G
K
V
L
PELNGKL
T
G
M
A
F
RVPT
P
NVSV
V
DL
T
V
R
L
E
K
A
A
T
Y
E
QIK
A
A
V
K
A
AA
E
G
EMK
G
VL
GYTE
DD
V
VS
T
DFNG
EVCT
SVFDA
KA
G
--
I
A
L
N
D
-N
F
VK
L
V
S
WYDNE
T
G
Y
S
N
KV
LDLIAHISK
fig|544404.4.peg.2404
Escherichia coli O157:H7 str. TW14359
MT
I
KVGINGFGRIGR
I
V
F
-
R
A
A
Q
--
K
RS
D
I
E
I
VAINDL
L
DA
DY
MAY
M
LKYDS
T
HGRF
D
G
T
V
EVKD
G
H
LIV
N
GK
K
IRV
T
AER
DPA
NL
K
W
D
E
V
GVDVV
A
E
A
TG
L
F
L
T
D
E
TA
R
K
HI
T
AGAKKV
V
M
T
G
P
-
S
K
D
NTP
M
F
V
K
G
A
N
F
D
K
Y
A
G
Q
D
-
IVSNASCTTNCLAP
L
AK
V
I
N
D
N
FGI
I
E
G
L
MTT
V
HA
T
T
A
TQ
KT
VDGP
S
HKD
W
R
GG
R
G
ASQNIIP
SS
TGAAKA
V
G
K
V
L
PELNGKL
T
G
M
A
F
RVPT
P
NVSV
V
DL
T
V
R
L
E
K
A
A
T
Y
E
QIK
A
A
V
K
A
AA
E
G
EMK
G
VL
GYTE
DD
V
VS
T
DFNG
EVCT
SVFDA
KA
G
--
I
A
L
N
D
-N
F
VK
L
V
S
WYDNE
T
G
Y
S
N
KV
LDLIAHISK
fig|502346.5.peg.4905
Escherichia coli O157:H7 str. TW14588
MT
I
KVGINGFGRIGR
I
V
F
-
R
A
A
Q
--
K
RS
D
I
E
I
VAINDL
L
DA
DY
MAY
M
LKYDS
T
HGRF
D
G
T
V
EVKD
G
H
LIV
N
GK
K
IRV
T
AER
DPA
NL
K
W
D
E
V
GVDVV
A
E
A
TG
L
F
L
T
D
E
TA
R
K
HI
T
AGAKKV
V
M
T
G
P
-
S
K
D
NTP
M
F
V
K
G
A
N
F
D
K
Y
A
G
Q
D
-
IVSNASCTTNCLAP
L
AK
V
I
N
D
N
FGI
I
E
G
L
MTT
V
HA
T
T
A
TQ
KT
VDGP
S
HKD
W
R
GG
R
G
ASQNIIP
SS
TGAAKA
V
G
K
V
L
PELNGKL
T
G
M
A
F
RVPT
P
NVSV
V
DL
T
V
R
L
E
K
A
A
T
Y
E
QIK
A
A
V
K
A
AA
E
G
EMK
G
VL
GYTE
DD
V
VS
T
DFNG
EVCT
SVFDA
KA
G
--
I
A
L
N
D
-N
F
VK
L
V
S
WYDNE
T
G
Y
S
N
KV
LDLIAHISK
fig|573235.3.peg.2586
Escherichia coli O26:H11 str. 11368
MT
I
KVGINGFGRIGR
I
V
F
-
R
A
A
Q
--
K
RS
D
I
E
I
VAINDL
L
DA
DY
MAY
M
LKYDS
T
HGRF
D
G
T
V
EVKD
G
H
LIV
N
GK
K
IRV
T
AER
DPA
NL
K
W
D
E
V
GVDVV
A
E
A
TG
L
F
L
T
D
E
TA
R
K
HI
T
AGAKKV
V
M
T
G
P
-
S
K
D
NTP
M
F
V
K
G
A
N
F
D
K
Y
A
G
Q
D
-
IVSNASCTTNCLAP
L
AK
V
I
N
D
N
FGI
I
E
G
L
MTT
V
HA
T
T
A
TQ
KT
VDGP
S
HKD
W
R
GG
R
G
ASQNIIP
SS
TGAAKA
V
G
K
V
L
PELNGKL
T
G
M
A
F
RVPT
P
NVSV
V
DL
T
V
R
L
E
K
A
A
T
Y
E
QIK
A
A
V
K
A
AA
E
G
EMK
G
VL
GYTE
DD
V
VS
T
DFNG
EVCT
SVFDA
KA
G
--
I
A
L
N
D
-N
F
VK
L
V
S
WYDNE
T
G
Y
S
N
KV
LDLIAHISK
fig|701177.3.peg.2230
Escherichia coli O55:H7 str. CB9615
MT
I
KVGINGFGRIGR
I
V
F
-
R
A
A
Q
--
K
RS
D
I
E
I
VAINDL
L
DA
DY
MAY
M
LKYDS
T
HGRF
D
G
T
V
EVKD
G
H
LIV
N
GK
K
IRV
T
AER
DPA
NL
K
W
D
E
V
GVDVV
A
E
A
TG
L
F
L
T
D
E
TA
R
K
HI
T
AGAKKV
V
M
T
G
P
-
S
K
D
NTP
M
F
V
K
G
A
N
F
D
K
Y
A
G
Q
D
-
IVSNASCTTNCLAP
L
AK
V
I
N
D
N
FGI
I
E
G
L
MTT
V
HA
T
T
A
TQ
KT
VDGP
S
HKD
W
R
GG
R
G
ASQNIIP
SS
TGAAKA
V
G
K
V
L
PELNGKL
T
G
M
A
F
RVPT
P
NVSV
V
DL
T
V
R
L
E
K
A
A
T
Y
E
QIK
A
A
V
K
A
AA
E
G
EMK
G
VL
GYTE
DD
V
VS
T
DFNG
EVCT
SVFDA
KA
G
--
I
A
L
N
D
-N
F
VK
L
V
S
WYDNE
T
G
Y
S
N
KV
LDLIAHISK
fig|685038.3.peg.1796
Escherichia coli O83:H1 str. NRG 857C
MT
I
KVGINGFGRIGR
I
V
F
-
R
A
A
Q
--
K
RS
D
I
E
I
VAINDL
L
DA
DY
MAY
M
LKYDS
T
HGRF
D
G
T
V
EVKD
G
H
LIV
N
GK
K
IRV
T
AER
DPA
NL
K
W
D
E
V
GVDVV
A
E
A
TG
L
F
L
T
D
E
TA
R
K
HI
T
AGAKKV
V
M
T
G
P
-
S
K
D
NTP
M
F
V
K
G
A
N
F
D
K
Y
A
G
Q
D
-
IVSNASCTTNCLAP
L
AK
V
I
N
D
N
FGI
I
E
G
L
MTT
V
HA
T
T
A
TQ
KT
VDGP
S
HKD
W
R
GG
R
G
ASQNIIP
SS
TGAAKA
V
G
K
V
L
PELNGKL
T
G
M
A
F
RVPT
P
NVSV
V
DL
T
V
R
L
E
K
A
A
T
Y
E
QIK
A
A
V
K
A
AA
E
G
EMK
G
VL
GYTE
DD
V
VS
T
DFNG
EVCT
SVFDA
KA
G
--
I
A
L
N
D
-N
F
VK
L
V
S
WYDNE
T
G
Y
S
N
KV
LDLIAHISK
fig|637912.3.peg.270
Escherichia coli OP50
MT
I
KVGINGFGRIGR
I
V
F
-
R
A
A
Q
--
K
RS
D
I
E
I
VAINDL
L
DA
DY
MAY
M
LKYDS
T
HGRF
D
G
T
V
EVKD
G
H
LIV
N
GK
K
IRV
T
AER
DPA
NL
K
W
D
E
V
GVDVV
A
E
A
TG
L
F
L
T
D
E
TA
R
K
HI
T
AGAKKV
V
M
T
G
P
-
S
K
D
NTP
M
F
V
K
G
A
N
F
D
K
Y
A
G
Q
D
-
IVSNASCTTNCLAP
L
AK
V
I
N
D
N
FGI
I
E
G
L
MTT
V
HA
T
T
A
TQ
KT
VDGP
S
HKD
W
R
GG
R
G
ASQNIIP
SS
TGAAKA
V
G
K
V
L
PELNGKL
T
G
M
A
F
RVPT
P
NVSV
V
DL
T
V
R
L
E
K
A
A
T
Y
E
QIK
A
A
V
K
A
AA
E
G
EMK
G
VL
GYTE
DD
V
VS
T
DFNG
EVCT
SVFDA
KA
G
--
I
A
L
N
D
-N
F
VK
L
V
S
WYDNE
T
G
Y
S
N
KV
LDLIAHISK
fig|585035.6.peg.1821
Escherichia coli S88
MT
I
KVGINGFGRIGR
I
V
F
-
R
A
A
Q
--
K
RS
D
I
E
I
VAINDL
L
DA
DY
MAY
M
LKYDS
T
HGRF
D
G
T
V
EVKD
G
H
LIV
N
GK
K
IRV
T
AER
DPA
NL
K
W
D
E
V
GVDVV
A
E
A
TG
L
F
L
T
D
E
TA
R
K
HI
T
AGAKKV
V
M
T
G
P
-
S
K
D
NTP
M
F
V
K
G
A
N
F
D
K
Y
A
G
Q
D
-
IVSNASCTTNCLAP
L
AK
V
I
N
D
N
FGI
I
E
G
L
MTT
V
HA
T
T
A
TQ
KT
VDGP
S
HKD
W
R
GG
R
G
ASQNIIP
SS
TGAAKA
V
G
K
V
L
PELNGKL
T
G
M
A
F
RVPT
P
NVSV
V
DL
T
V
R
L
E
K
A
A
T
Y
E
QIK
A
A
V
K
A
AA
E
G
EMK
G
VL
GYTE
DD
V
VS
T
DFNG
EVCT
SVFDA
KA
G
--
I
A
L
N
D
-N
F
VK
L
V
S
WYDNE
T
G
Y
S
N
KV
LDLIAHISK
fig|409438.11.peg.2098
Escherichia coli SE11
MT
I
KVGINGFGRIGR
I
V
F
-
R
A
A
Q
--
K
RS
D
I
E
I
VAINDL
L
DA
DY
MAY
M
LKYDS
T
HGRF
D
G
T
V
EVKD
G
H
LIV
N
GK
K
IRV
T
AER
DPA
NL
K
W
D
E
V
GVDVV
A
E
A
TG
L
F
L
T
D
E
TA
R
K
HI
T
AGAKKV
V
M
T
G
P
-
S
K
D
NTP
M
F
V
K
G
A
N
F
D
K
Y
A
G
Q
D
-
IVSNASCTTNCLAP
L
AK
V
I
N
D
N
FGI
I
E
G
L
MTT
V
HA
T
T
A
TQ
KT
VDGP
S
HKD
W
R
GG
R
G
ASQNIIP
SS
TGAAKA
V
G
K
V
L
PELNGKL
T
G
M
A
F
RVPT
P
NVSV
V
DL
T
V
R
L
E
K
A
A
T
Y
E
QIK
A
A
V
K
A
AA
E
G
EMK
G
VL
GYTE
DD
V
VS
T
DFNG
EVCT
SVFDA
KA
G
--
I
A
L
N
D
-N
F
VK
L
V
S
WYDNE
T
G
Y
S
N
KV
LDLIAHISK
fig|431946.3.peg.1701
Escherichia coli SE15
MT
I
KVGINGFGRIGR
I
V
F
-
R
A
A
Q
--
K
RS
D
I
E
I
VAINDL
L
DA
DY
MAY
M
LKYDS
T
HGRF
D
G
T
V
EVKD
G
H
LIV
N
GK
K
IRV
T
AER
DPA
NL
K
W
D
E
V
GVDVV
A
E
A
TG
L
F
L
T
D
E
TA
R
K
HI
T
AGAKKV
V
M
T
G
P
-
S
K
D
NTP
M
F
V
K
G
A
N
F
D
K
Y
A
G
Q
D
-
IVSNASCTTNCLAP
L
AK
V
I
N
D
N
FGI
I
E
G
L
MTT
V
HA
T
T
A
TQ
KT
VDGP
S
HKD
W
R
GG
R
G
ASQNIIP
SS
TGAAKA
V
G
K
V
L
PELNGKL
T
G
M
A
F
RVPT
P
NVSV
V
DL
T
V
R
L
E
K
A
A
T
Y
E
QIK
A
A
V
K
A
AA
E
G
EMK
G
VL
GYTE
DD
V
VS
T
DFNG
EVCT
SVFDA
KA
G
--
I
A
L
N
D
-N
F
VK
L
V
S
WYDNE
T
G
Y
S
N
KV
LDLIAHISK
fig|439855.10.peg.1570
Escherichia coli SMS-3-5
MT
I
KVGINGFGRIGR
I
V
F
-
R
A
A
Q
--
K
RS
D
I
E
I
VAINDL
L
DA
DY
MAY
M
LKYDS
T
HGRF
D
G
T
V
EVKD
G
H
LIV
N
GK
K
IRV
T
AER
DPA
NL
K
W
D
E
V
GVDVV
A
E
A
TG
L
F
L
T
D
E
TA
R
K
HI
T
AGAKKV
V
M
T
G
P
-
S
K
D
NTP
M
F
V
K
G
A
N
F
D
K
Y
A
G
Q
D
-
IVSNASCTTNCLAP
L
AK
V
I
N
D
N
FGI
I
E
G
L
MTT
V
HA
T
T
A
TQ
KT
VDGP
S
HKD
W
R
GG
R
G
ASQNIIP
SS
TGAAKA
V
G
K
V
L
PELNGKL
T
G
M
A
F
RVPT
P
NVSV
V
DL
T
V
R
L
E
K
A
A
T
Y
E
QIK
A
A
V
K
A
AA
E
G
EMK
G
VL
GYTE
DD
V
VS
T
DFNG
EVCT
SVFDA
KA
G
--
I
A
L
N
D
-N
F
VK
L
V
S
WYDNE
T
G
Y
S
N
KV
LDLIAHISK
fig|656437.3.peg.2011
Escherichia coli TA143
MT
I
KVGINGFGRIGR
I
V
F
-
R
A
A
Q
--
K
RS
D
I
E
I
VAINDL
L
DA
DY
MAY
M
LKYDS
T
HGRF
D
G
T
V
EVKD
G
H
LIV
N
GK
K
IRV
T
AER
DPA
NL
K
W
D
E
V
GVDVV
A
E
A
TG
L
F
L
T
D
E
TA
R
K
HI
T
AGAKKV
V
M
T
G
P
-
S
K
D
NTP
M
F
V
K
G
A
N
F
D
K
Y
A
G
Q
D
-
IVSNASCTTNCLAP
L
AK
V
I
N
D
N
FGI
I
E
G
L
MTT
V
HA
T
T
A
TQ
KT
VDGP
S
HKD
W
R
GG
R
G
ASQNIIP
SS
TGAAKA
V
G
K
V
L
PELNGKL
T
G
M
A
F
RVPT
P
NVSV
V
DL
T
V
R
L
E
K
A
A
T
Y
E
QIK
A
A
V
K
A
AA
E
G
EMK
G
VL
GYTE
DD
V
VS
T
DFNG
EVCT
SVFDA
KA
G
--
I
A
L
N
D
-N
F
VK
L
V
S
WYDNE
T
G
Y
S
N
KV
LDLIAHISK
fig|656443.3.peg.2449
Escherichia coli TA271
MT
I
KVGINGFGRIGR
I
V
F
-
R
A
A
Q
--
K
RS
D
I
E
I
VAINDL
L
DA
DY
MAY
M
LKYDS
T
HGRF
D
G
T
V
EVKD
G
H
LIV
N
GK
K
IRV
T
AER
DPA
NL
K
W
D
E
V
GVDVV
A
E
A
TG
L
F
L
T
D
E
TA
R
K
HI
T
AGAKKV
V
M
T
G
P
-
S
K
D
NTP
M
F
V
K
G
A
N
F
D
K
Y
A
G
Q
D
-
IVSNASCTTNCLAP
L
AK
V
I
N
D
N
FGI
I
E
G
L
MTT
V
HA
T
T
A
TQ
KT
VDGP
S
HKD
W
R
GG
R
G
ASQNIIP
SS
TGAAKA
V
G
K
V
L
PELNGKL
T
G
M
A
F
RVPT
P
NVSV
V
DL
T
V
R
L
E
K
A
A
T
Y
E
QIK
A
A
V
K
A
AA
E
G
EMK
G
VL
GYTE
DD
V
VS
T
DFNG
EVCT
SVFDA
KA
G
--
I
A
L
N
D
-N
F
VK
L
V
S
WYDNE
T
G
Y
S
N
KV
LDLIAHISK
fig|656444.3.peg.2696
Escherichia coli TA280
MT
I
KVGINGFGRIGR
I
V
F
-
R
A
A
Q
--
K
RS
D
I
E
I
VAINDL
L
DA
DY
MAY
M
LKYDS
T
HGRF
D
G
T
V
EVKD
G
H
LIV
N
GK
K
IRV
T
AER
DPA
NL
K
W
D
E
V
GVDVV
A
E
A
TG
L
F
L
T
D
E
TA
R
K
HI
T
AGAKKV
V
M
T
G
P
-
S
K
D
NTP
M
F
V
K
G
A
N
F
D
K
Y
A
G
Q
D
-
IVSNASCTTNCLAP
L
AK
V
I
N
D
N
FGI
I
E
G
L
MTT
V
HA
T
T
A
TQ
KT
VDGP
S
HKD
W
R
GG
R
G
ASQNIIP
SS
TGAAKA
V
G
K
V
L
PELNGKL
T
G
M
A
F
RVPT
P
NVSV
V
DL
T
V
R
L
E
K
A
A
T
Y
E
QIK
A
A
V
K
A
AA
E
G
EMK
G
VL
GYTE
DD
V
VS
T
DFNG
EVCT
SVFDA
KA
G
--
I
A
L
N
D
-N
F
VK
L
V
S
WYDNE
T
G
Y
S
N
KV
LDLIAHISK
fig|869729.3.peg.1751
Escherichia coli UM146
MT
I
KVGINGFGRIGR
I
V
F
-
R
A
A
Q
--
K
RS
D
I
E
I
VAINDL
L
DA
DY
MAY
M
LKYDS
T
HGRF
D
G
T
V
EVKD
G
H
LIV
N
GK
K
IRV
T
AER
DPA
NL
K
W
D
E
V
GVDVV
A
E
A
TG
L
F
L
T
D
E
TA
R
K
HI
T
AGAKKV
V
M
T
G
P
-
S
K
D
NTP
M
F
V
K
G
A
N
F
D
K
Y
A
G
Q
D
-
IVSNASCTTNCLAP
L
AK
V
I
N
D
N
FGI
I
E
G
L
MTT
V
HA
T
T
A
TQ
KT
VDGP
S
HKD
W
R
GG
R
G
ASQNIIP
SS
TGAAKA
V
G
K
V
L
PELNGKL
T
G
M
A
F
RVPT
P
NVSV
V
DL
T
V
R
L
E
K
A
A
T
Y
E
QIK
A
A
V
K
A
AA
E
G
EMK
G
VL
GYTE
DD
V
VS
T
DFNG
EVCT
SVFDA
KA
G
--
I
A
L
N
D
-N
F
VK
L
V
S
WYDNE
T
G
Y
S
N
KV
LDLIAHISK
fig|585056.7.peg.2255
Escherichia coli UMN026
MT
I
KVGINGFGRIGR
I
V
F
-
R
A
A
Q
--
K
RS
D
I
E
I
VAINDL
L
DA
DY
MAY
M
LKYDS
T
HGRF
D
G
T
V
EVKD
G
H
LIV
N
GK
K
IRV
T
AER
DPA
NL
K
W
D
E
V
GVDVV
A
E
A
TG
L
F
L
T
D
E
TA
R
K
HI
T
AGAKKV
V
M
T
G
P
-
S
K
D
NTP
M
F
V
K
G
A
N
F
D
K
Y
A
G
Q
D
-
IVSNASCTTNCLAP
L
AK
V
I
N
D
N
FGI
I
E
G
L
MTT
V
HA
T
T
A
TQ
KT
VDGP
S
HKD
W
R
GG
R
G
ASQNIIP
SS
TGAAKA
V
G
K
V
L
PELNGKL
T
G
M
A
F
RVPT
P
NVSV
V
DL
T
V
R
L
E
K
A
A
T
Y
E
QIK
A
A
V
K
A
AA
E
G
EMK
G
VL
GYTE
DD
V
VS
T
DFNG
EVCT
SVFDA
KA
G
--
I
A
L
N
D
-N
F
VK
L
V
S
WYDNE
T
G
Y
S
N
KV
LDLIAHISK
fig|364106.7.peg.2013
Escherichia coli UTI89
MT
I
KVGINGFGRIGR
I
V
F
-
R
A
A
Q
--
K
RS
D
I
E
I
VAINDL
L
DA
DY
MAY
M
LKYDS
T
HGRF
D
G
T
V
EVKD
G
H
LIV
N
GK
K
IRV
T
AER
DPA
NL
K
W
D
E
V
GVDVV
A
E
A
TG
L
F
L
T
D
E
TA
R
K
HI
T
AGAKKV
V
M
T
G
P
-
S
K
D
NTP
M
F
V
K
G
A
N
F
D
K
Y
A
G
Q
D
-
IVSNASCTTNCLAP
L
AK
V
I
N
D
N
FGI
I
E
G
L
MTT
V
HA
T
T
A
TQ
KT
VDGP
S
HKD
W
R
GG
R
G
ASQNIIP
SS
TGAAKA
V
G
K
V
L
PELNGKL
T
G
M
A
F
RVPT
P
NVSV
V
DL
T
V
R
L
E
K
A
A
T
Y
E
QIK
A
A
V
K
A
AA
E
G
EMK
G
VL
GYTE
DD
V
VS
T
DFNG
EVCT
SVFDA
KA
G
--
I
A
L
N
D
-N
F
VK
L
V
S
WYDNE
T
G
Y
S
N
KV
LDLIAHISK
fig|364106.8.peg.2016
Escherichia coli UTI89
MT
I
KVGINGFGRIGR
I
V
F
-
R
A
A
Q
--
K
RS
D
I
E
I
VAINDL
L
DA
DY
MAY
M
LKYDS
T
HGRF
D
G
T
V
EVKD
G
H
LIV
N
GK
K
IRV
T
AER
DPA
NL
K
W
D
E
V
GVDVV
A
E
A
TG
L
F
L
T
D
E
TA
R
K
HI
T
AGAKKV
V
M
T
G
P
-
S
K
D
NTP
M
F
V
K
G
A
N
F
D
K
Y
A
G
Q
D
-
IVSNASCTTNCLAP
L
AK
V
I
N
D
N
FGI
I
E
G
L
MTT
V
HA
T
T
A
TQ
KT
VDGP
S
HKD
W
R
GG
R
G
ASQNIIP
SS
TGAAKA
V
G
K
V
L
PELNGKL
T
G
M
A
F
RVPT
P
NVSV
V
DL
T
V
R
L
E
K
A
A
T
Y
E
QIK
A
A
V
K
A
AA
E
G
EMK
G
VL
GYTE
DD
V
VS
T
DFNG
EVCT
SVFDA
KA
G
--
I
A
L
N
D
-N
F
VK
L
V
S
WYDNE
T
G
Y
S
N
KV
LDLIAHISK
fig|566546.3.peg.859
Escherichia coli W
MT
I
KVGINGFGRIGR
I
V
F
-
R
A
A
Q
--
K
RS
D
I
E
I
VAINDL
L
DA
DY
MAY
M
LKYDS
T
HGRF
D
G
T
V
EVKD
G
H
LIV
N
GK
K
IRV
T
AER
DPA
NL
K
W
D
E
V
GVDVV
A
E
A
TG
L
F
L
T
D
E
TA
R
K
HI
T
AGAKKV
V
M
T
G
P
-
S
K
D
NTP
M
F
V
K
G
A
N
F
D
K
Y
A
G
Q
D
-
IVSNASCTTNCLAP
L
AK
V
I
N
D
N
FGI
I
E
G
L
MTT
V
HA
T
T
A
TQ
KT
VDGP
S
HKD
W
R
GG
R
G
ASQNIIP
SS
TGAAKA
V
G
K
V
L
PELNGKL
T
G
M
A
F
RVPT
P
NVSV
V
DL
T
V
R
L
E
K
A
A
T
Y
E
QIK
A
A
V
K
A
AA
E
G
EMK
G
VL
GYTE
DD
V
VS
T
DFNG
EVCT
SVFDA
KA
G
--
I
A
L
N
D
-N
F
VK
L
V
S
WYDNE
T
G
Y
S
N
KV
LDLIAHISK
fig|566546.4.peg.1937
Escherichia coli W
MT
I
KVGINGFGRIGR
I
V
F
-
R
A
A
Q
--
K
RS
D
I
E
I
VAINDL
L
DA
DY
MAY
M
LKYDS
T
HGRF
D
G
T
V
EVKD
G
H
LIV
N
GK
K
IRV
T
AER
DPA
NL
K
W
D
E
V
GVDVV
A
E
A
TG
L
F
L
T
D
E
TA
R
K
HI
T
AGAKKV
V
M
T
G
P
-
S
K
D
NTP
M
F
V
K
G
A
N
F
D
K
Y
A
G
Q
D
-
IVSNASCTTNCLAP
L
AK
V
I
N
D
N
FGI
I
E
G
L
MTT
V
HA
T
T
A
TQ
KT
VDGP
S
HKD
W
R
GG
R
G
ASQNIIP
SS
TGAAKA
V
G
K
V
L
PELNGKL
T
G
M
A
F
RVPT
P
NVSV
V
DL
T
V
R
L
E
K
A
A
T
Y
E
QIK
A
A
V
K
A
AA
E
G
EMK
G
VL
GYTE
DD
V
VS
T
DFNG
EVCT
SVFDA
KA
G
--
I
A
L
N
D
-N
F
VK
L
V
S
WYDNE
T
G
Y
S
N
KV
LDLIAHISK
fig|316407.3.peg.1734
Escherichia coli W3110
MT
I
KVGINGFGRIGR
I
V
F
-
R
A
A
Q
--
K
RS
D
I
E
I
VAINDL
L
DA
DY
MAY
M
LKYDS
T
HGRF
D
G
T
V
EVKD
G
H
LIV
N
GK
K
IRV
T
AER
DPA
NL
K
W
D
E
V
GVDVV
A
E
A
TG
L
F
L
T
D
E
TA
R
K
HI
T
AGAKKV
V
M
T
G
P
-
S
K
D
NTP
M
F
V
K
G
A
N
F
D
K
Y
A
G
Q
D
-
IVSNASCTTNCLAP
L
AK
V
I
N
D
N
FGI
I
E
G
L
MTT
V
HA
T
T
A
TQ
KT
VDGP
S
HKD
W
R
GG
R
G
ASQNIIP
SS
TGAAKA
V
G
K
V
L
PELNGKL
T
G
M
A
F
RVPT
P
NVSV
V
DL
T
V
R
L
E
K
A
A
T
Y
E
QIK
A
A
V
K
A
AA
E
G
EMK
G
VL
GYTE
DD
V
VS
T
DFNG
EVCT
SVFDA
KA
G
--
I
A
L
N
D
-N
F
VK
L
V
S
WYDNE
T
G
Y
S
N
KV
LDLIAHISK
fig|562.376.peg.2333
Escherichia coli WV_060327
MT
I
KVGINGFGRIGR
I
V
F
-
R
A
A
Q
--
K
RS
D
I
E
I
VAINDL
L
DA
DY
MAY
M
LKYDS
T
HGRF
D
G
T
V
EVKD
G
H
LIV
N
GK
K
IRV
T
AER
DPA
NL
K
W
D
E
V
GVDVV
A
E
A
TG
L
F
L
T
D
E
TA
R
K
HI
T
AGAKKV
V
M
T
G
P
-
S
K
D
NTP
M
F
V
K
G
A
N
F
D
K
Y
A
G
Q
D
-
IVSNASCTTNCLAP
L
AK
V
I
N
D
N
FGI
I
E
G
L
MTT
V
HA
T
T
A
TQ
KT
VDGP
S
HKD
W
R
GG
R
G
ASQNIIP
SS
TGAAKA
V
G
K
V
L
PELNGKL
T
G
M
A
F
RVPT
P
NVSV
V
DL
T
V
R
L
E
K
A
A
T
Y
E
QIK
A
A
V
K
A
AA
E
G
EMK
G
VL
GYTE
DD
V
VS
T
DFNG
EVCT
SVFDA
KA
G
--
I
A
L
N
D
-N
F
VK
L
V
S
WYDNE
T
G
Y
S
N
KV
LDLIAHISK
fig|316385.5.peg.1898
Escherichia coli str. K-12 substr. DH10B
MT
I
KVGINGFGRIGR
I
V
F
-
R
A
A
Q
--
K
RS
D
I
E
I
VAINDL
L
DA
DY
MAY
M
LKYDS
T
HGRF
D
G
T
V
EVKD
G
H
LIV
N
GK
K
IRV
T
AER
DPA
NL
K
W
D
E
V
GVDVV
A
E
A
TG
L
F
L
T
D
E
TA
R
K
HI
T
AGAKKV
V
M
T
G
P
-
S
K
D
NTP
M
F
V
K
G
A
N
F
D
K
Y
A
G
Q
D
-
IVSNASCTTNCLAP
L
AK
V
I
N
D
N
FGI
I
E
G
L
MTT
V
HA
T
T
A
TQ
KT
VDGP
S
HKD
W
R
GG
R
G
ASQNIIP
SS
TGAAKA
V
G
K
V
L
PELNGKL
T
G
M
A
F
RVPT
P
NVSV
V
DL
T
V
R
L
E
K
A
A
T
Y
E
QIK
A
A
V
K
A
AA
E
G
EMK
G
VL
GYTE
DD
V
VS
T
DFNG
EVCT
SVFDA
KA
G
--
I
A
L
N
D
-N
F
VK
L
V
S
WYDNE
T
G
Y
S
N
KV
LDLIAHISK
fig|316385.7.peg.1941
Escherichia coli str. K-12 substr. DH10B
MT
I
KVGINGFGRIGR
I
V
F
-
R
A
A
Q
--
K
RS
D
I
E
I
VAINDL
L
DA
DY
MAY
M
LKYDS
T
HGRF
D
G
T
V
EVKD
G
H
LIV
N
GK
K
IRV
T
AER
DPA
NL
K
W
D
E
V
GVDVV
A
E
A
TG
L
F
L
T
D
E
TA
R
K
HI
T
AGAKKV
V
M
T
G
P
-
S
K
D
NTP
M
F
V
K
G
A
N
F
D
K
Y
A
G
Q
D
-
IVSNASCTTNCLAP
L
AK
V
I
N
D
N
FGI
I
E
G
L
MTT
V
HA
T
T
A
TQ
KT
VDGP
S
HKD
W
R
GG
R
G
ASQNIIP
SS
TGAAKA
V
G
K
V
L
PELNGKL
T
G
M
A
F
RVPT
P
NVSV
V
DL
T
V
R
L
E
K
A
A
T
Y
E
QIK
A
A
V
K
A
AA
E
G
EMK
G
VL
GYTE
DD
V
VS
T
DFNG
EVCT
SVFDA
KA
G
--
I
A
L
N
D
-N
F
VK
L
V
S
WYDNE
T
G
Y
S
N
KV
LDLIAHISK
fig|511145.12.peg.1852
Escherichia coli str. K-12 substr. MG1655
MT
I
KVGINGFGRIGR
I
V
F
-
R
A
A
Q
--
K
RS
D
I
E
I
VAINDL
L
DA
DY
MAY
M
LKYDS
T
HGRF
D
G
T
V
EVKD
G
H
LIV
N
GK
K
IRV
T
AER
DPA
NL
K
W
D
E
V
GVDVV
A
E
A
TG
L
F
L
T
D
E
TA
R
K
HI
T
AGAKKV
V
M
T
G
P
-
S
K
D
NTP
M
F
V
K
G
A
N
F
D
K
Y
A
G
Q
D
-
IVSNASCTTNCLAP
L
AK
V
I
N
D
N
FGI
I
E
G
L
MTT
V
HA
T
T
A
TQ
KT
VDGP
S
HKD
W
R
GG
R
G
ASQNIIP
SS
TGAAKA
V
G
K
V
L
PELNGKL
T
G
M
A
F
RVPT
P
NVSV
V
DL
T
V
R
L
E
K
A
A
T
Y
E
QIK
A
A
V
K
A
AA
E
G
EMK
G
VL
GYTE
DD
V
VS
T
DFNG
EVCT
SVFDA
KA
G
--
I
A
L
N
D
-N
F
VK
L
V
S
WYDNE
T
G
Y
S
N
KV
LDLIAHISK
fig|511145.6.peg.1838
Escherichia coli str. K-12 substr. MG1655
MT
I
KVGINGFGRIGR
I
V
F
-
R
A
A
Q
--
K
RS
D
I
E
I
VAINDL
L
DA
DY
MAY
M
LKYDS
T
HGRF
D
G
T
V
EVKD
G
H
LIV
N
GK
K
IRV
T
AER
DPA
NL
K
W
D
E
V
GVDVV
A
E
A
TG
L
F
L
T
D
E
TA
R
K
HI
T
AGAKKV
V
M
T
G
P
-
S
K
D
NTP
M
F
V
K
G
A
N
F
D
K
Y
A
G
Q
D
-
IVSNASCTTNCLAP
L
AK
V
I
N
D
N
FGI
I
E
G
L
MTT
V
HA
T
T
A
TQ
KT
VDGP
S
HKD
W
R
GG
R
G
ASQNIIP
SS
TGAAKA
V
G
K
V
L
PELNGKL
T
G
M
A
F
RVPT
P
NVSV
V
DL
T
V
R
L
E
K
A
A
T
Y
E
QIK
A
A
V
K
A
AA
E
G
EMK
G
VL
GYTE
DD
V
VS
T
DFNG
EVCT
SVFDA
KA
G
--
I
A
L
N
D
-N
F
VK
L
V
S
WYDNE
T
G
Y
S
N
KV
LDLIAHISK
fig|679205.4.peg.2440
Escherichia coli MS 124-1
MT
I
KVGINGFGRIGR
I
V
F
-
R
A
A
Q
--
K
RS
D
I
E
I
VAINDL
L
DA
DY
MAY
M
LKYDS
T
HGRF
D
G
T
V
EVKD
G
H
LIV
N
GK
K
IRV
T
AER
DPA
NL
K
W
D
E
V
GVDVV
A
E
A
TG
L
F
L
T
D
E
TA
R
K
HI
T
AGAKKV
V
M
T
G
P
-
S
K
D
NTP
M
F
V
K
G
A
N
F
D
K
Y
A
G
Q
D
-
IVSNASCTTNCLAP
L
AK
V
I
N
D
N
FGI
I
E
G
L
MTT
V
HA
T
T
A
TQ
KT
VDGP
S
HKD
W
R
GG
R
G
ASQNIIP
SS
TGAAKA
V
G
K
V
L
PEL
S
GKL
T
G
M
A
F
RVPT
P
NVSV
V
DL
T
V
R
L
E
K
A
A
T
Y
E
QIK
A
A
V
K
A
AA
E
G
EMK
G
VL
GYTE
DD
V
VS
T
DFNG
EVCT
SVFDA
KA
G
--
I
A
L
N
D
-N
F
VK
L
V
S
WYDNE
T
G
Y
S
N
KV
LDLIAHISK
fig|749533.3.peg.2742
Escherichia coli MS 84-1
MT
I
KVGINGFGRIGR
I
V
F
-
R
A
A
Q
--
K
RS
D
I
E
I
VAINDL
L
DA
DY
MAY
M
LKYDS
T
HGRF
D
G
T
V
EVKD
G
H
LIV
N
GK
K
IRV
T
AER
DPA
NL
K
W
D
E
V
GVDVV
A
E
A
TG
L
F
L
T
D
E
TA
R
K
HI
T
AGAKKV
V
M
T
G
P
-
S
K
D
NTP
M
F
V
K
G
A
N
F
D
K
Y
A
G
Q
D
-
IVSNASCTTNCLAP
L
AK
V
I
N
D
N
FGI
I
E
G
L
MTT
V
HA
T
T
A
TQ
KT
VDGP
S
HKD
W
R
GG
R
G
ASQNIIP
SS
TGAAKA
V
G
K
V
L
PEL
S
GKL
T
G
M
A
F
RVPT
P
NVSV
V
DL
T
V
R
L
E
K
A
A
T
Y
E
QIK
A
A
V
K
A
AA
E
G
EMK
G
VL
GYTE
DD
V
VS
T
DFNG
EVCT
SVFDA
KA
G
--
I
A
L
N
D
-N
F
VK
L
V
S
WYDNE
T
G
Y
S
N
KV
LDLIAHISK
fig|405955.13.peg.1544
Escherichia coli APEC O1 (3-332/333)
KVGINGFGRIGR
L
V
L
RRL
L
E
--
V
K
S
N
I
D
VVAINDL
T
SP
KI
L
AYLLK
H
DS
N
Y
G
P
F
P
W
S
V
DYTE
D
S
LIV
N
GK
S
I
A
V
Y
AE
K
EAK
N
I
PW
K
A
K
G
AEII
V
ECTG
F
Y
T
S
A
E
KS
Q
AH
L
D
AGAKKVL
I
S
A
P
-
A
G
E
-MK
T
I
VY
N
VN
D
D
T
L
D
G
N
D
T
IVS
V
ASCTTNCLAP
M
AK
A
L
H
D
S
FGIE
V
GTMTTIHA
Y
T
G
TQ
SL
VDGP
R
G
KDLR
AS
RAA
AE
NIIP
HT
TGAAKAIG
L
V
I
PEL
S
GKL
K
G
H
A
Q
RVP
V
K
TG
SV
T
E
L
V
S
I
L
G
K
K
VTAEEVN
N
ALK
K
A
T
N
N
NES
-
-F
GYT
D
EE
I
VS
S
D
II
G
SHFG
SVFDATQ
T
EI
TAV
G
D
LQ
LVKTV
A
WYDNE
Y
GF
V
T
QL
IRTLEKFA
K
fig|405955.9.peg.1263
Escherichia coli APEC O1 (3-332/333)
KVGINGFGRIGR
L
V
L
RRL
L
E
--
V
K
S
N
I
D
VVAINDL
T
SP
KI
L
AYLLK
H
DS
N
Y
G
P
F
P
W
S
V
DYTE
D
S
LIV
N
GK
S
I
A
V
Y
AE
K
EAK
N
I
PW
K
A
K
G
AEII
V
ECTG
F
Y
T
S
A
E
KS
Q
AH
L
D
AGAKKVL
I
S
A
P
-
A
G
E
-MK
T
I
VY
N
VN
D
D
T
L
D
G
N
D
T
IVS
V
ASCTTNCLAP
M
AK
A
L
H
D
S
FGIE
V
GTMTTIHA
Y
T
G
TQ
SL
VDGP
R
G
KDLR
AS
RAA
AE
NIIP
HT
TGAAKAIG
L
V
I
PEL
S
GKL
K
G
H
A
Q
RVP
V
K
TG
SV
T
E
L
V
S
I
L
G
K
K
VTAEEVN
N
ALK
K
A
T
N
N
NES
-
-F
GYT
D
EE
I
VS
S
D
II
G
SHFG
SVFDATQ
T
EI
TAV
G
D
LQ
LVKTV
A
WYDNE
Y
GF
V
T
QL
IRTLEKFA
K
fig|714962.3.peg.1611
Escherichia coli IHE3034 (3-332/333)
KVGINGFGRIGR
L
V
L
RRL
L
E
--
V
K
S
N
I
D
VVAINDL
T
SP
KI
L
AYLLK
H
DS
N
Y
G
P
F
P
W
S
V
DYTE
D
S
LIV
N
GK
S
I
A
V
Y
AE
K
EAK
N
I
PW
K
A
K
G
AEII
V
ECTG
F
Y
T
S
A
E
KS
Q
AH
L
D
AGAKKVL
I
S
A
P
-
A
G
E
-MK
T
I
VY
N
VN
D
D
T
L
D
G
N
D
T
IVS
V
ASCTTNCLAP
M
AK
A
L
H
D
S
FGIE
V
GTMTTIHA
Y
T
G
TQ
SL
VDGP
R
G
KDLR
AS
RAA
AE
NIIP
HT
TGAAKAIG
L
V
I
PEL
S
GKL
K
G
H
A
Q
RVP
V
K
TG
SV
T
E
L
V
S
I
L
G
K
K
VTAEEVN
N
ALK
K
A
T
N
N
NES
-
-F
GYT
D
EE
I
VS
S
D
II
G
SHFG
SVFDATQ
T
EI
TAV
G
D
LQ
LVKTV
A
WYDNE
Y
GF
V
T
QL
IRTLEKFA
K
fig|585035.6.peg.1502
Escherichia coli S88 (3-332/333)
KVGINGFGRIGR
L
V
L
RRL
L
E
--
V
K
S
N
I
D
VVAINDL
T
SP
KI
L
AYLLK
H
DS
N
Y
G
P
F
P
W
S
V
DYTE
D
S
LIV
N
GK
S
I
A
V
Y
AE
K
EAK
N
I
PW
K
A
K
G
AEII
V
ECTG
F
Y
T
S
A
E
KS
Q
AH
L
D
AGAKKVL
I
S
A
P
-
A
G
E
-MK
T
I
VY
N
VN
D
D
T
L
D
G
N
D
T
IVS
V
ASCTTNCLAP
M
AK
A
L
H
D
S
FGIE
V
GTMTTIHA
Y
T
G
TQ
SL
VDGP
R
G
KDLR
AS
RAA
AE
NIIP
HT
TGAAKAIG
L
V
I
PEL
S
GKL
K
G
H
A
Q
RVP
V
K
TG
SV
T
E
L
V
S
I
L
G
K
K
VTAEEVN
N
ALK
K
A
T
N
N
NES
-
-F
GYT
D
EE
I
VS
S
D
II
G
SHFG
SVFDATQ
T
EI
TAV
G
D
LQ
LVKTV
A
WYDNE
Y
GF
V
T
QL
IRTLEKFA
K
fig|869729.3.peg.2109
Escherichia coli UM146 (3-332/333)
KVGINGFGRIGR
L
V
L
RRL
L
E
--
V
K
S
N
I
D
VVAINDL
T
SP
KI
L
AYLLK
H
DS
N
Y
G
P
F
P
W
S
V
DYTE
D
S
LIV
N
GK
S
I
A
V
Y
AE
K
EAK
N
I
PW
K
A
K
G
AEII
V
ECTG
F
Y
T
S
A
E
KS
Q
AH
L
D
AGAKKVL
I
S
A
P
-
A
G
E
-MK
T
I
VY
N
VN
D
D
T
L
D
G
N
D
T
IVS
V
ASCTTNCLAP
M
AK
A
L
H
D
S
FGIE
V
GTMTTIHA
Y
T
G
TQ
SL
VDGP
R
G
KDLR
AS
RAA
AE
NIIP
HT
TGAAKAIG
L
V
I
PEL
S
GKL
K
G
H
A
Q
RVP
V
K
TG
SV
T
E
L
V
S
I
L
G
K
K
VTAEEVN
N
ALK
K
A
T
N
N
NES
-
-F
GYT
D
EE
I
VS
S
D
II
G
SHFG
SVFDATQ
T
EI
TAV
G
D
LQ
LVKTV
A
WYDNE
Y
GF
V
T
QL
IRTLEKFA
K
fig|364106.7.peg.1681
Escherichia coli UTI89 (3-332/333)
KVGINGFGRIGR
L
V
L
RRL
L
E
--
V
K
S
N
I
D
VVAINDL
T
SP
KI
L
AYLLK
H
DS
N
Y
G
P
F
P
W
S
V
DYTE
D
S
LIV
N
GK
S
I
A
V
Y
AE
K
EAK
N
I
PW
K
A
K
G
AEII
V
ECTG
F
Y
T
S
A
E
KS
Q
AH
L
D
AGAKKVL
I
S
A
P
-
A
G
E
-MK
T
I
VY
N
VN
D
D
T
L
D
G
N
D
T
IVS
V
ASCTTNCLAP
M
AK
A
L
H
D
S
FGIE
V
GTMTTIHA
Y
T
G
TQ
SL
VDGP
R
G
KDLR
AS
RAA
AE
NIIP
HT
TGAAKAIG
L
V
I
PEL
S
GKL
K
G
H
A
Q
RVP
V
K
TG
SV
T
E
L
V
S
I
L
G
K
K
VTAEEVN
N
ALK
K
A
T
N
N
NES
-
-F
GYT
D
EE
I
VS
S
D
II
G
SHFG
SVFDATQ
T
EI
TAV
G
D
LQ
LVKTV
A
WYDNE
Y
GF
V
T
QL
IRTLEKFA
K
fig|364106.8.peg.1682
Escherichia coli UTI89 (3-332/333)
KVGINGFGRIGR
L
V
L
RRL
L
E
--
V
K
S
N
I
D
VVAINDL
T
SP
KI
L
AYLLK
H
DS
N
Y
G
P
F
P
W
S
V
DYTE
D
S
LIV
N
GK
S
I
A
V
Y
AE
K
EAK
N
I
PW
K
A
K
G
AEII
V
ECTG
F
Y
T
S
A
E
KS
Q
AH
L
D
AGAKKVL
I
S
A
P
-
A
G
E
-MK
T
I
VY
N
VN
D
D
T
L
D
G
N
D
T
IVS
V
ASCTTNCLAP
M
AK
A
L
H
D
S
FGIE
V
GTMTTIHA
Y
T
G
TQ
SL
VDGP
R
G
KDLR
AS
RAA
AE
NIIP
HT
TGAAKAIG
L
V
I
PEL
S
GKL
K
G
H
A
Q
RVP
V
K
TG
SV
T
E
L
V
S
I
L
G
K
K
VTAEEVN
N
ALK
K
A
T
N
N
NES
-
-F
GYT
D
EE
I
VS
S
D
II
G
SHFG
SVFDATQ
T
EI
TAV
G
D
LQ
LVKTV
A
WYDNE
Y
GF
V
T
QL
IRTLEKFA
K
fig|550676.3.peg.984
Escherichia coli B185 (3-332/333)
KVGINGFGRIGR
L
V
L
RRL
L
E
--
V
K
S
N
I
D
VVAINDL
T
SP
KI
L
AYLLK
H
DS
N
Y
G
P
F
P
W
S
V
DFTE
D
S
LIV
N
GK
S
I
A
V
Y
AE
K
EAK
N
I
PW
K
A
K
G
AEII
V
ECTG
F
Y
T
S
A
E
KS
Q
AH
L
D
AGAKKVL
I
S
A
P
-
A
G
E
-MK
T
I
VY
N
VN
D
D
T
L
D
G
N
D
T
IVS
V
ASCTTNCLAP
M
AK
A
L
H
D
S
FGIE
V
GTMTTIHA
Y
T
G
TQ
SL
VDGP
R
G
KDLR
AS
RAA
AE
NIIP
HT
TGAAKAIG
L
V
I
PEL
S
GKL
K
G
H
A
Q
RVP
V
K
TG
SV
T
E
L
V
S
I
L
G
K
K
VTAEEVN
N
ALK
Q
A
T
T
N
NES
-
-F
GYT
D
EE
I
VS
S
D
II
G
SHFG
SVFDATQ
T
EI
TAV
G
D
LQ
LVKTV
A
WYDNE
Y
GF
V
T
QL
IRTLEKFA
K
fig|656419.3.peg.1988
Escherichia coli M718 (3-332/333)
KVGINGFGRIGR
L
V
L
RRL
L
E
--
V
K
S
N
I
D
VVAINDL
T
SP
KI
L
AYLLK
H
DS
N
Y
G
P
F
P
W
S
V
DFTE
D
S
LIV
N
GK
S
I
A
V
Y
AE
K
EAK
N
I
PW
K
A
K
G
AEII
V
ECTG
F
Y
T
S
A
E
KS
Q
AH
L
D
AGAKKVL
I
S
A
P
-
A
G
E
-MK
T
I
VY
N
VN
D
D
T
L
D
G
N
D
T
IVS
V
ASCTTNCLAP
M
AK
A
L
H
D
S
FGIE
V
GTMTTIHA
Y
T
G
TQ
SL
VDGP
R
G
KDLR
AS
RAA
AE
NIIP
HT
TGAAKAIG
L
V
I
PEL
S
GKL
K
G
H
A
Q
RVP
V
K
TG
SV
T
E
L
V
S
I
L
G
K
K
VTAEEVN
N
ALK
Q
A
T
T
N
NES
-
-F
GYT
D
EE
I
VS
S
D
II
G
SHFG
SVFDATQ
T
EI
TAV
G
D
LQ
LVKTV
A
WYDNE
Y
GF
V
T
QL
IRTLEKFA
K
fig|670897.3.peg.4929
Escherichia coli 2362-75 (3-332/333)
KVGINGFGRIGR
L
V
L
RRL
L
E
--
V
K
S
N
I
D
VVAINDL
T
SP
KI
L
AYLLK
H
DS
N
Y
G
P
F
P
W
S
V
DYTE
D
S
LIV
D
GK
S
I
A
V
Y
AE
K
EAK
N
I
PW
K
A
K
G
AEII
V
ECTG
F
Y
T
S
A
E
KS
Q
AH
L
D
AGAKKVL
I
S
A
P
-
A
G
E
-MK
T
I
VY
N
VN
D
D
T
L
D
G
N
D
T
IVS
V
ASCTTNCLAP
M
AK
V
L
H
D
S
FGIE
V
GTMTTIHA
Y
T
G
TQ
SL
VDGP
R
G
KDLR
AS
RAA
AE
NIIP
HT
TGAAKAIG
L
V
I
PEL
S
GKL
K
G
H
A
Q
RVP
V
K
TG
SV
T
E
L
V
S
I
L
G
K
K
VTAEEVN
N
ALK
K
A
T
N
N
NES
-
-F
GYT
D
EE
I
VS
S
D
II
G
SHFG
SVFDATQ
T
EI
TAV
G
D
LQ
LVKTV
A
WYDNE
Y
GF
V
T
QL
IRTLEKFA
K
fig|216593.1.peg.2011
Escherichia coli E2348/69 (3-332/333)
KVGINGFGRIGR
L
V
L
RRL
L
E
--
V
K
S
N
I
D
VVAINDL
T
SP
KI
L
AYLLK
H
DS
N
Y
G
P
F
P
W
S
V
DYTE
D
S
LIV
D
GK
S
I
A
V
Y
AE
K
EAK
N
I
PW
K
A
K
G
AEII
V
ECTG
F
Y
T
S
A
E
KS
Q
AH
L
D
AGAKKVL
I
S
A
P
-
A
G
E
-MK
T
I
VY
N
VN
D
D
T
L
D
G
N
D
T
IVS
V
ASCTTNCLAP
M
AK
V
L
H
D
S
FGIE
V
GTMTTIHA
Y
T
G
TQ
SL
VDGP
R
G
KDLR
AS
RAA
AE
NIIP
HT
TGAAKAIG
L
V
I
PEL
S
GKL
K
G
H
A
Q
RVP
V
K
TG
SV
T
E
L
V
S
I
L
G
K
K
VTAEEVN
N
ALK
K
A
T
N
N
NES
-
-F
GYT
D
EE
I
VS
S
D
II
G
SHFG
SVFDATQ
T
EI
TAV
G
D
LQ
LVKTV
A
WYDNE
Y
GF
V
T
QL
IRTLEKFA
K
fig|574521.7.peg.1587
Escherichia coli O127:H6 str. E2348/69 (3-332/333)
KVGINGFGRIGR
L
V
L
RRL
L
E
--
V
K
S
N
I
D
VVAINDL
T
SP
KI
L
AYLLK
H
DS
N
Y
G
P
F
P
W
S
V
DYTE
D
S
LIV
D
GK
S
I
A
V
Y
AE
K
EAK
N
I
PW
K
A
K
G
AEII
V
ECTG
F
Y
T
S
A
E
KS
Q
AH
L
D
AGAKKVL
I
S
A
P
-
A
G
E
-MK
T
I
VY
N
VN
D
D
T
L
D
G
N
D
T
IVS
V
ASCTTNCLAP
M
AK
V
L
H
D
S
FGIE
V
GTMTTIHA
Y
T
G
TQ
SL
VDGP
R
G
KDLR
AS
RAA
AE
NIIP
HT
TGAAKAIG
L
V
I
PEL
S
GKL
K
G
H
A
Q
RVP
V
K
TG
SV
T
E
L
V
S
I
L
G
K
K
VTAEEVN
N
ALK
K
A
T
N
N
NES
-
-F
GYT
D
EE
I
VS
S
D
II
G
SHFG
SVFDATQ
T
EI
TAV
G
D
LQ
LVKTV
A
WYDNE
Y
GF
V
T
QL
IRTLEKFA
K
fig|550677.3.peg.2830
Escherichia coli B354 (3-332/333)
KVGINGFGRIGR
L
V
L
RRL
L
E
--
V
K
S
N
I
D
I
VAINDL
T
SP
KI
L
AYLLK
H
DS
N
Y
G
P
F
P
W
S
V
DFTE
D
S
LIV
D
GK
S
I
A
V
Y
AE
K
EAK
N
I
PW
K
A
K
G
AEII
V
ECTG
F
Y
T
S
A
E
KS
Q
AH
L
D
AGAKKVL
I
S
A
P
-
A
G
E
-MK
T
I
VY
N
VN
D
D
T
L
D
G
N
D
T
IVS
V
ASCTTNCLAP
M
AK
A
L
H
D
S
FGIE
V
GTMTTIHA
Y
T
G
TQ
SL
VDGP
R
G
KDLR
AS
RAA
AE
NIIP
HT
TGAAKAIG
L
V
I
PEL
S
GKL
K
G
H
A
Q
RVP
V
K
TG
SV
T
E
L
V
S
I
L
G
K
K
VTAEEVN
N
ALK
K
A
T
N
N
NES
-
-F
GYT
D
EE
I
VS
S
D
II
G
SHFG
SVFDATQ
T
EI
TAV
G
D
LQ
LVKTV
A
WYDNE
Y
GF
V
T
QL
IRTLEKFA
K
fig|749527.3.peg.3780
Escherichia coli MS 21-1 (3-332/333)
KVGINGFGRIGR
L
V
L
RRL
L
E
--
V
K
S
N
I
D
I
VAINDL
T
SP
KI
L
AYLLK
H
DS
N
Y
G
P
F
P
W
S
V
DFTE
D
S
LIV
D
GK
S
I
A
V
Y
AE
K
EAK
N
I
PW
K
A
K
G
AEII
V
ECTG
F
Y
T
S
A
E
KS
Q
AH
L
D
AGAKKVL
I
S
A
P
-
A
G
E
-MK
T
I
VY
N
VN
D
D
T
L
D
G
N
D
T
IVS
V
ASCTTNCLAP
M
AK
A
L
H
D
S
FGIE
V
GTMTTIHA
Y
T
G
TQ
SL
VDGP
R
G
KDLR
AS
RAA
AE
NIIP
HT
TGAAKAIG
L
V
I
PEL
S
GKL
K
G
H
A
Q
RVP
V
K
TG
SV
T
E
L
V
S
I
L
G
K
K
VTAEEVN
N
ALK
Q
A
T
T
N
NES
-
-F
GYT
D
EE
I
VS
S
D
II
G
SHFG
SVFDATQ
T
EI
TAV
G
D
LQ
LVKTV
A
WYDNE
Y
GF
V
T
QL
IRTLEKFA
K
fig|439855.10.peg.1911
Escherichia coli SMS-3-5 (3-332/333)
KVGINGFGRIGR
L
V
L
RRL
L
E
--
V
K
S
N
I
D
I
VAINDL
T
SP
KI
L
AYLLK
H
DS
N
Y
G
P
F
P
W
S
V
DFTE
D
S
LIV
D
GK
S
I
A
V
Y
AE
K
EAK
N
I
PW
K
A
K
G
AEII
V
ECTG
F
Y
T
S
A
E
KS
Q
AH
L
D
AGAKKVL
I
S
A
P
-
A
G
E
-MK
T
I
VY
N
VN
D
D
T
L
D
G
N
D
T
IVS
V
ASCTTNCLAP
M
AK
A
L
H
D
S
FGIE
V
GTMTTIHA
Y
T
G
TQ
SL
VDGP
R
G
KDLR
AS
RAA
AE
NIIP
HT
TGAAKAIG
L
V
I
PEL
S
GKL
K
G
H
A
Q
RVP
V
K
TG
SV
T
E
L
V
S
I
L
G
K
K
VTAEEVN
N
ALK
Q
A
T
T
N
NES
-
-F
GYT
D
EE
I
VS
S
D
II
G
SHFG
SVFDATQ
T
EI
TAV
G
D
LQ
LVKTV
A
WYDNE
Y
GF
V
T
QL
IRTLEKFA
K
fig|749531.3.peg.369
Escherichia coli MS 69-1 (3-332/333)
KVGINGFGRIGR
L
V
L
RRL
L
E
--
V
K
S
N
I
D
I
VAINDL
T
SP
KI
L
AYLLK
H
DS
N
Y
G
P
F
P
W
S
V
DFTE
D
S
LIV
D
GK
S
I
A
V
Y
AE
K
EAK
N
I
PW
K
A
K
G
AEII
V
ECTG
F
Y
T
S
A
E
KS
Q
AH
L
D
AGAKKVL
I
S
A
P
-
A
G
E
-MK
T
I
VY
N
VN
D
D
T
L
D
G
N
D
T
IVS
V
ASCTTNCLAP
M
AK
A
L
H
D
S
FGIE
V
GTMTTIHA
Y
T
G
TQ
SL
VDGP
R
G
KDLR
AS
RAA
AE
NIIP
HT
TGAAKAIG
L
V
I
PEL
S
GKL
K
G
H
A
Q
RVP
V
K
TG
SV
T
E
L
V
S
I
L
G
K
K
VTAEEVN
N
ALK
N
A
T
N
N
NES
-
-F
GYT
D
EE
I
VS
S
D
II
G
SHFG
SVFDATQ
T
EI
TAV
G
D
LQ
LVKTV
A
WYDNE
Y
GF
V
T
QL
IRTLEKFA
K
fig|656393.3.peg.2149
Escherichia coli H299 (3-332/333)
KVGINGFGRIGR
L
V
L
RRL
L
E
--
V
K
S
N
I
D
VVAINDL
T
SP
KI
L
AYLLK
H
DS
N
Y
G
P
F
P
W
S
V
DFTE
D
S
LIV
D
GK
S
I
A
V
Y
AE
K
EAK
N
I
PW
K
A
K
G
AEII
V
ECTG
F
Y
T
S
A
E
KS
Q
AH
L
D
AGAKKVL
I
S
A
P
-
A
G
E
-MK
T
I
VY
N
VN
D
D
T
L
D
G
N
D
T
IVS
V
ASCTTNCLAP
M
AK
A
L
H
D
S
FGIE
V
GTMTTIHA
Y
T
G
TQ
SL
VDGP
R
G
KDLR
AS
RAA
AE
NIIP
HT
TGAAKAIG
L
V
I
PEL
S
GKL
K
G
H
A
Q
RVP
V
K
TG
SV
T
E
L
V
S
I
L
A
K
K
VTAEEVN
N
ALK
Q
A
T
T
N
NES
-
-F
GYT
D
EE
I
VS
S
D
II
G
SHFG
SVFDATQ
T
EI
TAV
G
D
LQ
LVKTV
A
WYDNE
Y
GF
V
T
QL
IRTLEKFA
K
fig|562.371.peg.1797
Escherichia coli 1044A (3-332/333)
KVGINGFGRIGR
L
V
L
RRL
L
E
--
V
K
S
N
I
D
VVAINDL
T
SP
KI
L
AYLLK
H
DS
N
Y
G
P
F
P
W
S
V
DFTE
D
S
LIV
D
GK
S
I
A
V
Y
AE
K
EAK
N
I
PW
K
A
K
G
AEII
V
ECTG
F
Y
T
S
A
E
KS
Q
AH
L
D
AGAKKVL
I
S
A
P
-
A
G
E
-MK
T
I
VY
K
VN
D
D
T
L
D
G
N
D
T
IVS
V
ASCTTNCLAP
M
AK
A
L
H
D
S
FGIE
V
GTMTTIHA
Y
T
G
TQ
SL
VDGP
R
G
KDLR
AS
RAA
AE
NIIP
HT
TGAAKAIG
L
V
I
PEL
S
GKL
K
G
H
A
Q
RVP
V
K
TG
SV
T
E
L
V
S
I
L
G
K
K
VTAEEVN
N
ALK
Q
A
T
T
N
NES
-
-F
GYT
D
EE
I
VS
S
D
II
G
SHFG
SVFDATQ
T
EI
TAV
G
D
LQ
LVKTV
A
WYDNE
Y
GF
V
T
QL
IRTLEKFA
K
fig|562.373.peg.5144
Escherichia coli 1125A (3-332/333)
KVGINGFGRIGR
L
V
L
RRL
L
E
--
V
K
S
N
I
D
VVAINDL
T
SP
KI
L
AYLLK
H
DS
N
Y
G
P
F
P
W
S
V
DFTE
D
S
LIV
D
GK
S
I
A
V
Y
AE
K
EAK
N
I
PW
K
A
K
G
AEII
V
ECTG
F
Y
T
S
A
E
KS
Q
AH
L
D
AGAKKVL
I
S
A
P
-
A
G
E
-MK
T
I
VY
K
VN
D
D
T
L
D
G
N
D
T
IVS
V
ASCTTNCLAP
M
AK
A
L
H
D
S
FGIE
V
GTMTTIHA
Y
T
G
TQ
SL
VDGP
R
G
KDLR
AS
RAA
AE
NIIP
HT
TGAAKAIG
L
V
I
PEL
S
GKL
K
G
H
A
Q
RVP
V
K
TG
SV
T
E
L
V
S
I
L
G
K
K
VTAEEVN
N
ALK
Q
A
T
T
N
NES
-
-F
GYT
D
EE
I
VS
S
D
II
G
SHFG
SVFDATQ
T
EI
TAV
G
D
LQ
LVKTV
A
WYDNE
Y
GF
V
T
QL
IRTLEKFA
K
fig|562.372.peg.1282
Escherichia coli 1212A (3-332/333)
KVGINGFGRIGR
L
V
L
RRL
L
E
--
V
K
S
N
I
D
VVAINDL
T
SP
KI
L
AYLLK
H
DS
N
Y
G
P
F
P
W
S
V
DFTE
D
S
LIV
D
GK
S
I
A
V
Y
AE
K
EAK
N
I
PW
K
A
K
G
AEII
V
ECTG
F
Y
T
S
A
E
KS
Q
AH
L
D
AGAKKVL
I
S
A
P
-
A
G
E
-MK
T
I
VY
K
VN
D
D
T
L
D
G
N
D
T
IVS
V
ASCTTNCLAP
M
AK
A
L
H
D
S
FGIE
V
GTMTTIHA
Y
T
G
TQ
SL
VDGP
R
G
KDLR
AS
RAA
AE
NIIP
HT
TGAAKAIG
L
V
I
PEL
S
GKL
K
G
H
A
Q
RVP
V
K
TG
SV
T
E
L
V
S
I
L
G
K
K
VTAEEVN
N
ALK
Q
A
T
T
N
NES
-
-F
GYT
D
EE
I
VS
S
D
II
G
SHFG
SVFDATQ
T
EI
TAV
G
D
LQ
LVKTV
A
WYDNE
Y
GF
V
T
QL
IRTLEKFA
K
fig|562.374.peg.2303
Escherichia coli 536A (3-332/333)
KVGINGFGRIGR
L
V
L
RRL
L
E
--
V
K
S
N
I
D
VVAINDL
T
SP
KI
L
AYLLK
H
DS
N
Y
G
P
F
P
W
S
V
DFTE
D
S
LIV
D
GK
S
I
A
V
Y
AE
K
EAK
N
I
PW
K
A
K
G
AEII
V
ECTG
F
Y
T
S
A
E
KS
Q
AH
L
D
AGAKKVL
I
S
A
P
-
A
G
E
-MK
T
I
VY
K
VN
D
D
T
L
D
G
N
D
T
IVS
V
ASCTTNCLAP
M
AK
A
L
H
D
S
FGIE
V
GTMTTIHA
Y
T
G
TQ
SL
VDGP
R
G
KDLR
AS
RAA
AE
NIIP
HT
TGAAKAIG
L
V
I
PEL
S
GKL
K
G
H
A
Q
RVP
V
K
TG
SV
T
E
L
V
S
I
L
G
K
K
VTAEEVN
N
ALK
Q
A
T
T
N
NES
-
-F
GYT
D
EE
I
VS
S
D
II
G
SHFG
SVFDATQ
T
EI
TAV
G
D
LQ
LVKTV
A
WYDNE
Y
GF
V
T
QL
IRTLEKFA
K
fig|83334.1.peg.2051
Escherichia coli O157:H7 (3-332/333)
KVGINGFGRIGR
L
V
L
RRL
L
E
--
V
K
S
N
I
D
VVAINDL
T
SP
KI
L
AYLLK
H
DS
N
Y
G
P
F
P
W
S
V
DFTE
D
S
LIV
D
GK
S
I
A
V
Y
AE
K
EAK
N
I
PW
K
A
K
G
AEII
V
ECTG
F
Y
T
S
A
E
KS
Q
AH
L
D
AGAKKVL
I
S
A
P
-
A
G
E
-MK
T
I
VY
K
VN
D
D
T
L
D
G
N
D
T
IVS
V
ASCTTNCLAP
M
AK
A
L
H
D
S
FGIE
V
GTMTTIHA
Y
T
G
TQ
SL
VDGP
R
G
KDLR
AS
RAA
AE
NIIP
HT
TGAAKAIG
L
V
I
PEL
S
GKL
K
G
H
A
Q
RVP
V
K
TG
SV
T
E
L
V
S
I
L
G
K
K
VTAEEVN
N
ALK
Q
A
T
T
N
NES
-
-F
GYT
D
EE
I
VS
S
D
II
G
SHFG
SVFDATQ
T
EI
TAV
G
D
LQ
LVKTV
A
WYDNE
Y
GF
V
T
QL
IRTLEKFA
K
fig|155864.1.peg.2053
Escherichia coli O157:H7 EDL933 (3-332/333)
KVGINGFGRIGR
L
V
L
RRL
L
E
--
V
K
S
N
I
D
VVAINDL
T
SP
KI
L
AYLLK
H
DS
N
Y
G
P
F
P
W
S
V
DFTE
D
S
LIV
D
GK
S
I
A
V
Y
AE
K
EAK
N
I
PW
K
A
K
G
AEII
V
ECTG
F
Y
T
S
A
E
KS
Q
AH
L
D
AGAKKVL
I
S
A
P
-
A
G
E
-MK
T
I
VY
K
VN
D
D
T
L
D
G
N
D
T
IVS
V
ASCTTNCLAP
M
AK
A
L
H
D
S
FGIE
V
GTMTTIHA
Y
T
G
TQ
SL
VDGP
R
G
KDLR
AS
RAA
AE
NIIP
HT
TGAAKAIG
L
V
I
PEL
S
GKL
K
G
H
A
Q
RVP
V
K
TG
SV
T
E
L
V
S
I
L
G
K
K
VTAEEVN
N
ALK
Q
A
T
T
N
NES
-
-F
GYT
D
EE
I
VS
S
D
II
G
SHFG
SVFDATQ
T
EI
TAV
G
D
LQ
LVKTV
A
WYDNE
Y
GF
V
T
QL
IRTLEKFA
K
fig|155864.8.peg.1879
Escherichia coli O157:H7 EDL933 (3-332/333)
KVGINGFGRIGR
L
V
L
RRL
L
E
--
V
K
S
N
I
D
VVAINDL
T
SP
KI
L
AYLLK
H
DS
N
Y
G
P
F
P
W
S
V
DFTE
D
S
LIV
D
GK
S
I
A
V
Y
AE
K
EAK
N
I
PW
K
A
K
G
AEII
V
ECTG
F
Y
T
S
A
E
KS
Q
AH
L
D
AGAKKVL
I
S
A
P
-
A
G
E
-MK
T
I
VY
K
VN
D
D
T
L
D
G
N
D
T
IVS
V
ASCTTNCLAP
M
AK
A
L
H
D
S
FGIE
V
GTMTTIHA
Y
T
G
TQ
SL
VDGP
R
G
KDLR
AS
RAA
AE
NIIP
HT
TGAAKAIG
L
V
I
PEL
S
GKL
K
G
H
A
Q
RVP
V
K
TG
SV
T
E
L
V
S
I
L
G
K
K
VTAEEVN
N
ALK
Q
A
T
T
N
NES
-
-F
GYT
D
EE
I
VS
S
D
II
G
SHFG
SVFDATQ
T
EI
TAV
G
D
LQ
LVKTV
A
WYDNE
Y
GF
V
T
QL
IRTLEKFA
K
fig|444454.5.peg.353
Escherichia coli O157:H7 str. EC4024 (3-332/333)
KVGINGFGRIGR
L
V
L
RRL
L
E
--
V
K
S
N
I
D
VVAINDL
T
SP
KI
L
AYLLK
H
DS
N
Y
G
P
F
P
W
S
V
DFTE
D
S
LIV
D
GK
S
I
A
V
Y
AE
K
EAK
N
I
PW
K
A
K
G
AEII
V
ECTG
F
Y
T
S
A
E
KS
Q
AH
L
D
AGAKKVL
I
S
A
P
-
A
G
E
-MK
T
I
VY
K
VN
D
D
T
L
D
G
N
D
T
IVS
V
ASCTTNCLAP
M
AK
A
L
H
D
S
FGIE
V
GTMTTIHA
Y
T
G
TQ
SL
VDGP
R
G
KDLR
AS
RAA
AE
NIIP
HT
TGAAKAIG
L
V
I
PEL
S
GKL
K
G
H
A
Q
RVP
V
K
TG
SV
T
E
L
V
S
I
L
G
K
K
VTAEEVN
N
ALK
Q
A
T
T
N
NES
-
-F
GYT
D
EE
I
VS
S
D
II
G
SHFG
SVFDATQ
T
EI
TAV
G
D
LQ
LVKTV
A
WYDNE
Y
GF
V
T
QL
IRTLEKFA
K
fig|444449.5.peg.253
Escherichia coli O157:H7 str. EC4042 (3-332/333)
KVGINGFGRIGR
L
V
L
RRL
L
E
--
V
K
S
N
I
D
VVAINDL
T
SP
KI
L
AYLLK
H
DS
N
Y
G
P
F
P
W
S
V
DFTE
D
S
LIV
D
GK
S
I
A
V
Y
AE
K
EAK
N
I
PW
K
A
K
G
AEII
V
ECTG
F
Y
T
S
A
E
KS
Q
AH
L
D
AGAKKVL
I
S
A
P
-
A
G
E
-MK
T
I
VY
K
VN
D
D
T
L
D
G
N
D
T
IVS
V
ASCTTNCLAP
M
AK
A
L
H
D
S
FGIE
V
GTMTTIHA
Y
T
G
TQ
SL
VDGP
R
G
KDLR
AS
RAA
AE
NIIP
HT
TGAAKAIG
L
V
I
PEL
S
GKL
K
G
H
A
Q
RVP
V
K
TG
SV
T
E
L
V
S
I
L
G
K
K
VTAEEVN
N
ALK
Q
A
T
T
N
NES
-
-F
GYT
D
EE
I
VS
S
D
II
G
SHFG
SVFDATQ
T
EI
TAV
G
D
LQ
LVKTV
A
WYDNE
Y
GF
V
T
QL
IRTLEKFA
K
fig|444448.5.peg.4609
Escherichia coli O157:H7 str. EC4045 (3-332/333)
KVGINGFGRIGR
L
V
L
RRL
L
E
--
V
K
S
N
I
D
VVAINDL
T
SP
KI
L
AYLLK
H
DS
N
Y
G
P
F
P
W
S
V
DFTE
D
S
LIV
D
GK
S
I
A
V
Y
AE
K
EAK
N
I
PW
K
A
K
G
AEII
V
ECTG
F
Y
T
S
A
E
KS
Q
AH
L
D
AGAKKVL
I
S
A
P
-
A
G
E
-MK
T
I
VY
K
VN
D
D
T
L
D
G
N
D
T
IVS
V
ASCTTNCLAP
M
AK
A
L
H
D
S
FGIE
V
GTMTTIHA
Y
T
G
TQ
SL
VDGP
R
G
KDLR
AS
RAA
AE
NIIP
HT
TGAAKAIG
L
V
I
PEL
S
GKL
K
G
H
A
Q
RVP
V
K
TG
SV
T
E
L
V
S
I
L
G
K
K
VTAEEVN
N
ALK
Q
A
T
T
N
NES
-
-F
GYT
D
EE
I
VS
S
D
II
G
SHFG
SVFDATQ
T
EI
TAV
G
D
LQ
LVKTV
A
WYDNE
Y
GF
V
T
QL
IRTLEKFA
K
fig|444453.5.peg.4218
Escherichia coli O157:H7 str. EC4076 (3-332/333)
KVGINGFGRIGR
L
V
L
RRL
L
E
--
V
K
S
N
I
D
VVAINDL
T
SP
KI
L
AYLLK
H
DS
N
Y
G
P
F
P
W
S
V
DFTE
D
S
LIV
D
GK
S
I
A
V
Y
AE
K
EAK
N
I
PW
K
A
K
G
AEII
V
ECTG
F
Y
T
S
A
E
KS
Q
AH
L
D
AGAKKVL
I
S
A
P
-
A
G
E
-MK
T
I
VY
K
VN
D
D
T
L
D
G
N
D
T
IVS
V
ASCTTNCLAP
M
AK
A
L
H
D
S
FGIE
V
GTMTTIHA
Y
T
G
TQ
SL
VDGP
R
G
KDLR
AS
RAA
AE
NIIP
HT
TGAAKAIG
L
V
I
PEL
S
GKL
K
G
H
A
Q
RVP
V
K
TG
SV
T
E
L
V
S
I
L
G
K
K
VTAEEVN
N
ALK
Q
A
T
T
N
NES
-
-F
GYT
D
EE
I
VS
S
D
II
G
SHFG
SVFDATQ
T
EI
TAV
G
D
LQ
LVKTV
A
WYDNE
Y
GF
V
T
QL
IRTLEKFA
K
fig|444452.5.peg.2014
Escherichia coli O157:H7 str. EC4113 (3-332/333)
KVGINGFGRIGR
L
V
L
RRL
L
E
--
V
K
S
N
I
D
VVAINDL
T
SP
KI
L
AYLLK
H
DS
N
Y
G
P
F
P
W
S
V
DFTE
D
S
LIV
D
GK
S
I
A
V
Y
AE
K
EAK
N
I
PW
K
A
K
G
AEII
V
ECTG
F
Y
T
S
A
E
KS
Q
AH
L
D
AGAKKVL
I
S
A
P
-
A
G
E
-MK
T
I
VY
K
VN
D
D
T
L
D
G
N
D
T
IVS
V
ASCTTNCLAP
M
AK
A
L
H
D
S
FGIE
V
GTMTTIHA
Y
T
G
TQ
SL
VDGP
R
G
KDLR
AS
RAA
AE
NIIP
HT
TGAAKAIG
L
V
I
PEL
S
GKL
K
G
H
A
Q
RVP
V
K
TG
SV
T
E
L
V
S
I
L
G
K
K
VTAEEVN
N
ALK
Q
A
T
T
N
NES
-
-F
GYT
D
EE
I
VS
S
D
II
G
SHFG
SVFDATQ
T
EI
TAV
G
D
LQ
LVKTV
A
WYDNE
Y
GF
V
T
QL
IRTLEKFA
K
fig|444450.8.peg.2071
Escherichia coli O157:H7 str. EC4115 (3-332/333)
KVGINGFGRIGR
L
V
L
RRL
L
E
--
V
K
S
N
I
D
VVAINDL
T
SP
KI
L
AYLLK
H
DS
N
Y
G
P
F
P
W
S
V
DFTE
D
S
LIV
D
GK
S
I
A
V
Y
AE
K
EAK
N
I
PW
K
A
K
G
AEII
V
ECTG
F
Y
T
S
A
E
KS
Q
AH
L
D
AGAKKVL
I
S
A
P
-
A
G
E
-MK
T
I
VY
K
VN
D
D
T
L
D
G
N
D
T
IVS
V
ASCTTNCLAP
M
AK
A
L
H
D
S
FGIE
V
GTMTTIHA
Y
T
G
TQ
SL
VDGP
R
G
KDLR
AS
RAA
AE
NIIP
HT
TGAAKAIG
L
V
I
PEL
S
GKL
K
G
H
A
Q
RVP
V
K
TG
SV
T
E
L
V
S
I
L
G
K
K
VTAEEVN
N
ALK
Q
A
T
T
N
NES
-
-F
GYT
D
EE
I
VS
S
D
II
G
SHFG
SVFDATQ
T
EI
TAV
G
D
LQ
LVKTV
A
WYDNE
Y
GF
V
T
QL
IRTLEKFA
K
fig|444451.5.peg.4659
Escherichia coli O157:H7 str. EC4196 (3-332/333)
KVGINGFGRIGR
L
V
L
RRL
L
E
--
V
K
S
N
I
D
VVAINDL
T
SP
KI
L
AYLLK
H
DS
N
Y
G
P
F
P
W
S
V
DFTE
D
S
LIV
D
GK
S
I
A
V
Y
AE
K
EAK
N
I
PW
K
A
K
G
AEII
V
ECTG
F
Y
T
S
A
E
KS
Q
AH
L
D
AGAKKVL
I
S
A
P
-
A
G
E
-MK
T
I
VY
K
VN
D
D
T
L
D
G
N
D
T
IVS
V
ASCTTNCLAP
M
AK
A
L
H
D
S
FGIE
V
GTMTTIHA
Y
T
G
TQ
SL
VDGP
R
G
KDLR
AS
RAA
AE
NIIP
HT
TGAAKAIG
L
V
I
PEL
S
GKL
K
G
H
A
Q
RVP
V
K
TG
SV
T
E
L
V
S
I
L
G
K
K
VTAEEVN
N
ALK
Q
A
T
T
N
NES
-
-F
GYT
D
EE
I
VS
S
D
II
G
SHFG
SVFDATQ
T
EI
TAV
G
D
LQ
LVKTV
A
WYDNE
Y
GF
V
T
QL
IRTLEKFA
K
fig|444447.5.peg.5518
Escherichia coli O157:H7 str. EC4206 (3-332/333)
KVGINGFGRIGR
L
V
L
RRL
L
E
--
V
K
S
N
I
D
VVAINDL
T
SP
KI
L
AYLLK
H
DS
N
Y
G
P
F
P
W
S
V
DFTE
D
S
LIV
D
GK
S
I
A
V
Y
AE
K
EAK
N
I
PW
K
A
K
G
AEII
V
ECTG
F
Y
T
S
A
E
KS
Q
AH
L
D
AGAKKVL
I
S
A
P
-
A
G
E
-MK
T
I
VY
K
VN
D
D
T
L
D
G
N
D
T
IVS
V
ASCTTNCLAP
M
AK
A
L
H
D
S
FGIE
V
GTMTTIHA
Y
T
G
TQ
SL
VDGP
R
G
KDLR
AS
RAA
AE
NIIP
HT
TGAAKAIG
L
V
I
PEL
S
GKL
K
G
H
A
Q
RVP
V
K
TG
SV
T
E
L
V
S
I
L
G
K
K
VTAEEVN
N
ALK
Q
A
T
T
N
NES
-
-F
GYT
D
EE
I
VS
S
D
II
G
SHFG
SVFDATQ
T
EI
TAV
G
D
LQ
LVKTV
A
WYDNE
Y
GF
V
T
QL
IRTLEKFA
K
fig|478004.5.peg.2800
Escherichia coli O157:H7 str. EC4401 (3-332/333)
KVGINGFGRIGR
L
V
L
RRL
L
E
--
V
K
S
N
I
D
VVAINDL
T
SP
KI
L
AYLLK
H
DS
N
Y
G
P
F
P
W
S
V
DFTE
D
S
LIV
D
GK
S
I
A
V
Y
AE
K
EAK
N
I
PW
K
A
K
G
AEII
V
ECTG
F
Y
T
S
A
E
KS
Q
AH
L
D
AGAKKVL
I
S
A
P
-
A
G
E
-MK
T
I
VY
K
VN
D
D
T
L
D
G
N
D
T
IVS
V
ASCTTNCLAP
M
AK
A
L
H
D
S
FGIE
V
GTMTTIHA
Y
T
G
TQ
SL
VDGP
R
G
KDLR
AS
RAA
AE
NIIP
HT
TGAAKAIG
L
V
I
PEL
S
GKL
K
G
H
A
Q
RVP
V
K
TG
SV
T
E
L
V
S
I
L
G
K
K
VTAEEVN
N
ALK
Q
A
T
T
N
NES
-
-F
GYT
D
EE
I
VS
S
D
II
G
SHFG
SVFDATQ
T
EI
TAV
G
D
LQ
LVKTV
A
WYDNE
Y
GF
V
T
QL
IRTLEKFA
K
fig|478005.5.peg.3378
Escherichia coli O157:H7 str. EC4486 (3-332/333)
KVGINGFGRIGR
L
V
L
RRL
L
E
--
V
K
S
N
I
D
VVAINDL
T
SP
KI
L
AYLLK
H
DS
N
Y
G
P
F
P
W
S
V
DFTE
D
S
LIV
D
GK
S
I
A
V
Y
AE
K
EAK
N
I
PW
K
A
K
G
AEII
V
ECTG
F
Y
T
S
A
E
KS
Q
AH
L
D
AGAKKVL
I
S
A
P
-
A
G
E
-MK
T
I
VY
K
VN
D
D
T
L
D
G
N
D
T
IVS
V
ASCTTNCLAP
M
AK
A
L
H
D
S
FGIE
V
GTMTTIHA
Y
T
G
TQ
SL
VDGP
R
G
KDLR
AS
RAA
AE
NIIP
HT
TGAAKAIG
L
V
I
PEL
S
GKL
K
G
H
A
Q
RVP
V
K
TG
SV
T
E
L
V
S
I
L
G
K
K
VTAEEVN
N
ALK
Q
A
T
T
N
NES
-
-F
GYT
D
EE
I
VS
S
D
II
G
SHFG
SVFDATQ
T
EI
TAV
G
D
LQ
LVKTV
A
WYDNE
Y
GF
V
T
QL
IRTLEKFA
K
fig|478006.5.peg.3513
Escherichia coli O157:H7 str. EC4501 (3-332/333)
KVGINGFGRIGR
L
V
L
RRL
L
E
--
V
K
S
N
I
D
VVAINDL
T
SP
KI
L
AYLLK
H
DS
N
Y
G
P
F
P
W
S
V
DFTE
D
S
LIV
D
GK
S
I
A
V
Y
AE
K
EAK
N
I
PW
K
A
K
G
AEII
V
ECTG
F
Y
T
S
A
E
KS
Q
AH
L
D
AGAKKVL
I
S
A
P
-
A
G
E
-MK
T
I
VY
K
VN
D
D
T
L
D
G
N
D
T
IVS
V
ASCTTNCLAP
M
AK
A
L
H
D
S
FGIE
V
GTMTTIHA
Y
T
G
TQ
SL
VDGP
R
G
KDLR
AS
RAA
AE
NIIP
HT
TGAAKAIG
L
V
I
PEL
S
GKL
K
G
H
A
Q
RVP
V
K
TG
SV
T
E
L
V
S
I
L
G
K
K
VTAEEVN
N
ALK
Q
A
T
T
N
NES
-
-F
GYT
D
EE
I
VS
S
D
II
G
SHFG
SVFDATQ
T
EI
TAV
G
D
LQ
LVKTV
A
WYDNE
Y
GF
V
T
QL
IRTLEKFA
K
fig|478007.5.peg.2419
Escherichia coli O157:H7 str. EC508 (3-332/333)
KVGINGFGRIGR
L
V
L
RRL
L
E
--
V
K
S
N
I
D
VVAINDL
T
SP
KI
L
AYLLK
H
DS
N
Y
G
P
F
P
W
S
V
DFTE
D
S
LIV
D
GK
S
I
A
V
Y
AE
K
EAK
N
I
PW
K
A
K
G
AEII
V
ECTG
F
Y
T
S
A
E
KS
Q
AH
L
D
AGAKKVL
I
S
A
P
-
A
G
E
-MK
T
I
VY
K
VN
D
D
T
L
D
G
N
D
T
IVS
V
ASCTTNCLAP
M
AK
A
L
H
D
S
FGIE
V
GTMTTIHA
Y
T
G
TQ
SL
VDGP
R
G
KDLR
AS
RAA
AE
NIIP
HT
TGAAKAIG
L
V
I
PEL
S
GKL
K
G
H
A
Q
RVP
V
K
TG
SV
T
E
L
V
S
I
L
G
K
K
VTAEEVN
N
ALK
Q
A
T
T
N
NES
-
-F
GYT
D
EE
I
VS
S
D
II
G
SHFG
SVFDATQ
T
EI
TAV
G
D
LQ
LVKTV
A
WYDNE
Y
GF
V
T
QL
IRTLEKFA
K
fig|478008.5.peg.3488
Escherichia coli O157:H7 str. EC869 (3-332/333)
KVGINGFGRIGR
L
V
L
RRL
L
E
--
V
K
S
N
I
D
VVAINDL
T
SP
KI
L
AYLLK
H
DS
N
Y
G
P
F
P
W
S
V
DFTE
D
S
LIV
D
GK
S
I
A
V
Y
AE
K
EAK
N
I
PW
K
A
K
G
AEII
V
ECTG
F
Y
T
S
A
E
KS
Q
AH
L
D
AGAKKVL
I
S
A
P
-
A
G
E
-MK
T
I
VY
K
VN
D
D
T
L
D
G
N
D
T
IVS
V
ASCTTNCLAP
M
AK
A
L
H
D
S
FGIE
V
GTMTTIHA
Y
T
G
TQ
SL
VDGP
R
G
KDLR
AS
RAA
AE
NIIP
HT
TGAAKAIG
L
V
I
PEL
S
GKL
K
G
H
A
Q
RVP
V
K
TG
SV
T
E
L
V
S
I
L
G
K
K
VTAEEVN
N
ALK
Q
A
T
T
N
NES
-
-F
GYT
D
EE
I
VS
S
D
II
G
SHFG
SVFDATQ
T
EI
TAV
G
D
LQ
LVKTV
A
WYDNE
Y
GF
V
T
QL
IRTLEKFA
K
fig|637388.3.peg.1442
Escherichia coli O157:H7 str. FRIK2000 (3-332/333)
KVGINGFGRIGR
L
V
L
RRL
L
E
--
V
K
S
N
I
D
VVAINDL
T
SP
KI
L
AYLLK
H
DS
N
Y
G
P
F
P
W
S
V
DFTE
D
S
LIV
D
GK
S
I
A
V
Y
AE
K
EAK
N
I
PW
K
A
K
G
AEII
V
ECTG
F
Y
T
S
A
E
KS
Q
AH
L
D
AGAKKVL
I
S
A
P
-
A
G
E
-MK
T
I
VY
K
VN
D
D
T
L
D
G
N
D
T
IVS
V
ASCTTNCLAP
M
AK
A
L
H
D
S
FGIE
V
GTMTTIHA
Y
T
G
TQ
SL
VDGP
R
G
KDLR
AS
RAA
AE
NIIP
HT
TGAAKAIG
L
V
I
PEL
S
GKL
K
G
H
A
Q
RVP
V
K
TG
SV
T
E
L
V
S
I
L
G
K
K
VTAEEVN
N
ALK
Q
A
T
T
N
NES
-
-F
GYT
D
EE
I
VS
S
D
II
G
SHFG
SVFDATQ
T
EI
TAV
G
D
LQ
LVKTV
A
WYDNE
Y
GF
V
T
QL
IRTLEKFA
K
fig|570506.3.peg.3271
Escherichia coli O157:H7 str. FRIK966 (3-332/333)
KVGINGFGRIGR
L
V
L
RRL
L
E
--
V
K
S
N
I
D
VVAINDL
T
SP
KI
L
AYLLK
H
DS
N
Y
G
P
F
P
W
S
V
DFTE
D
S
LIV
D
GK
S
I
A
V
Y
AE
K
EAK
N
I
PW
K
A
K
G
AEII
V
ECTG
F
Y
T
S
A
E
KS
Q
AH
L
D
AGAKKVL
I
S
A
P
-
A
G
E
-MK
T
I
VY
K
VN
D
D
T
L
D
G
N
D
T
IVS
V
ASCTTNCLAP
M
AK
A
L
H
D
S
FGIE
V
GTMTTIHA
Y
T
G
TQ
SL
VDGP
R
G
KDLR
AS
RAA
AE
NIIP
HT
TGAAKAIG
L
V
I
PEL
S
GKL
K
G
H
A
Q
RVP
V
K
TG
SV
T
E
L
V
S
I
L
G
K
K
VTAEEVN
N
ALK
Q
A
T
T
N
NES
-
-F
GYT
D
EE
I
VS
S
D
II
G
SHFG
SVFDATQ
T
EI
TAV
G
D
LQ
LVKTV
A
WYDNE
Y
GF
V
T
QL
IRTLEKFA
K
fig|386585.9.peg.2123
Escherichia coli O157:H7 str. Sakai (3-332/333)
KVGINGFGRIGR
L
V
L
RRL
L
E
--
V
K
S
N
I
D
VVAINDL
T
SP
KI
L
AYLLK
H
DS
N
Y
G
P
F
P
W
S
V
DFTE
D
S
LIV
D
GK
S
I
A
V
Y
AE
K
EAK
N
I
PW
K
A
K
G
AEII
V
ECTG
F
Y
T
S
A
E
KS
Q
AH
L
D
AGAKKVL
I
S
A
P
-
A
G
E
-MK
T
I
VY
K
VN
D
D
T
L
D
G
N
D
T
IVS
V
ASCTTNCLAP
M
AK
A
L
H
D
S
FGIE
V
GTMTTIHA
Y
T
G
TQ
SL
VDGP
R
G
KDLR
AS
RAA
AE
NIIP
HT
TGAAKAIG
L
V
I
PEL
S
GKL
K
G
H
A
Q
RVP
V
K
TG
SV
T
E
L
V
S
I
L
G
K
K
VTAEEVN
N
ALK
Q
A
T
T
N
NES
-
-F
GYT
D
EE
I
VS
S
D
II
G
SHFG
SVFDATQ
T
EI
TAV
G
D
LQ
LVKTV
A
WYDNE
Y
GF
V
T
QL
IRTLEKFA
K
fig|544404.4.peg.1932
Escherichia coli O157:H7 str. TW14359 (3-332/333)
KVGINGFGRIGR
L
V
L
RRL
L
E
--
V
K
S
N
I
D
VVAINDL
T
SP
KI
L
AYLLK
H
DS
N
Y
G
P
F
P
W
S
V
DFTE
D
S
LIV
D
GK
S
I
A
V
Y
AE
K
EAK
N
I
PW
K
A
K
G
AEII
V
ECTG
F
Y
T
S
A
E
KS
Q
AH
L
D
AGAKKVL
I
S
A
P
-
A
G
E
-MK
T
I
VY
K
VN
D
D
T
L
D
G
N
D
T
IVS
V
ASCTTNCLAP
M
AK
A
L
H
D
S
FGIE
V
GTMTTIHA
Y
T
G
TQ
SL
VDGP
R
G
KDLR
AS
RAA
AE
NIIP
HT
TGAAKAIG
L
V
I
PEL
S
GKL
K
G
H
A
Q
RVP
V
K
TG
SV
T
E
L
V
S
I
L
G
K
K
VTAEEVN
N
ALK
Q
A
T
T
N
NES
-
-F
GYT
D
EE
I
VS
S
D
II
G
SHFG
SVFDATQ
T
EI
TAV
G
D
LQ
LVKTV
A
WYDNE
Y
GF
V
T
QL
IRTLEKFA
K
fig|502346.5.peg.5349
Escherichia coli O157:H7 str. TW14588 (3-332/333)
KVGINGFGRIGR
L
V
L
RRL
L
E
--
V
K
S
N
I
D
VVAINDL
T
SP
KI
L
AYLLK
H
DS
N
Y
G
P
F
P
W
S
V
DFTE
D
S
LIV
D
GK
S
I
A
V
Y
AE
K
EAK
N
I
PW
K
A
K
G
AEII
V
ECTG
F
Y
T
S
A
E
KS
Q
AH
L
D
AGAKKVL
I
S
A
P
-
A
G
E
-MK
T
I
VY
K
VN
D
D
T
L
D
G
N
D
T
IVS
V
ASCTTNCLAP
M
AK
A
L
H
D
S
FGIE
V
GTMTTIHA
Y
T
G
TQ
SL
VDGP
R
G
KDLR
AS
RAA
AE
NIIP
HT
TGAAKAIG
L
V
I
PEL
S
GKL
K
G
H
A
Q
RVP
V
K
TG
SV
T
E
L
V
S
I
L
G
K
K
VTAEEVN
N
ALK
Q
A
T
T
N
NES
-
-F
GYT
D
EE
I
VS
S
D
II
G
SHFG
SVFDATQ
T
EI
TAV
G
D
LQ
LVKTV
A
WYDNE
Y
GF
V
T
QL
IRTLEKFA
K
fig|701177.3.peg.1767
Escherichia coli O55:H7 str. CB9615 (3-332/333)
KVGINGFGRIGR
L
V
L
RRL
L
E
--
V
K
S
N
I
D
VVAINDL
T
SP
KI
L
AYLLK
H
DS
N
Y
G
P
F
P
W
S
V
DFTE
D
S
LIV
D
GK
S
I
A
V
Y
AE
K
EAK
N
I
PW
K
A
K
G
AEII
V
ECTG
F
Y
T
S
A
E
KS
Q
AH
L
D
AGAKKVL
I
S
A
P
-
A
G
E
-MK
T
I
VY
K
VN
D
D
T
L
D
G
N
D
T
IVS
V
ASCTTNCLAP
M
AK
A
L
H
D
S
FGIE
V
GTMTTIHA
Y
T
G
TQ
SL
VDGP
R
G
KDLR
AS
RAA
AE
NIIP
HT
TGAAKAIG
L
V
I
PEL
S
GKL
K
G
H
A
Q
RVP
V
K
TG
SV
T
E
L
V
S
I
L
G
K
K
VTAEEVN
N
ALK
Q
A
T
T
N
NES
-
-F
GYT
D
EE
I
VS
S
D
II
G
SHFG
SVFDATQ
T
EI
TAV
G
D
LQ
LVKTV
A
WYDNE
Y
GF
V
T
QL
IRTLEKFA
K
fig|340184.3.peg.149
Escherichia coli B7A (3-332/333)
KVGINGFGRIGR
L
V
L
RRL
L
E
--
V
K
S
N
I
D
VVAINDL
T
SP
KI
L
AYLLK
H
DS
N
Y
G
P
F
P
W
S
V
DFTE
D
S
LIV
D
GK
S
I
S
V
Y
AE
K
EAK
N
I
PW
K
A
K
G
AEII
V
ECTG
F
Y
T
S
A
E
KS
Q
AH
L
D
AGAKKVL
I
S
A
P
-
A
G
E
-MK
T
I
VY
N
VN
D
D
T
L
D
G
N
D
T
IVS
V
ASCTTNCLAP
M
AK
A
L
H
D
S
FGIE
V
GTMTTIHA
Y
T
G
TQ
SL
VDGP
R
G
KDLR
AS
RAA
AE
NIIP
HT
TGAAKAIG
L
V
I
PEL
S
GKL
K
G
H
A
Q
RVP
V
K
TG
SV
T
E
L
V
S
I
L
G
K
K
VTAEEVN
N
ALK
Q
A
T
T
N
NES
-
-F
GYT
D
EE
I
VS
S
D
II
G
SHFG
SVFDATQ
T
EI
TAV
G
D
LQ
LVKTV
A
WYDNE
Y
GF
V
T
QL
IRTLEKFA
K
fig|340184.6.peg.154
Escherichia coli B7A (3-332/333)
KVGINGFGRIGR
L
V
L
RRL
L
E
--
V
K
S
N
I
D
VVAINDL
T
SP
KI
L
AYLLK
H
DS
N
Y
G
P
F
P
W
S
V
DFTE
D
S
LIV
D
GK
S
I
S
V
Y
AE
K
EAK
N
I
PW
K
A
K
G
AEII
V
ECTG
F
Y
T
S
A
E
KS
Q
AH
L
D
AGAKKVL
I
S
A
P
-
A
G
E
-MK
T
I
VY
N
VN
D
D
T
L
D
G
N
D
T
IVS
V
ASCTTNCLAP
M
AK
A
L
H
D
S
FGIE
V
GTMTTIHA
Y
T
G
TQ
SL
VDGP
R
G
KDLR
AS
RAA
AE
NIIP
HT
TGAAKAIG
L
V
I
PEL
S
GKL
K
G
H
A
Q
RVP
V
K
TG
SV
T
E
L
V
S
I
L
G
K
K
VTAEEVN
N
ALK
Q
A
T
T
N
NES
-
-F
GYT
D
EE
I
VS
S
D
II
G
SHFG
SVFDATQ
T
EI
TAV
G
D
LQ
LVKTV
A
WYDNE
Y
GF
V
T
QL
IRTLEKFA
K
fig|331111.12.peg.1882
Escherichia coli E24377A (3-332/333)
KVGINGFGRIGR
L
V
L
RRL
L
E
--
V
K
S
N
I
D
VVAINDL
T
SP
KI
L
AYLLK
H
DS
N
Y
G
P
F
P
W
S
V
DFTE
D
S
LIV
D
GK
S
I
S
V
Y
AE
K
EAK
N
I
PW
K
A
K
G
AEII
V
ECTG
F
Y
T
S
A
E
KS
Q
AH
L
D
AGAKKVL
I
S
A
P
-
A
G
E
-MK
T
I
VY
N
VN
D
D
T
L
D
G
N
D
T
IVS
V
ASCTTNCLAP
M
AK
A
L
H
D
S
FGIE
V
GTMTTIHA
Y
T
G
TQ
SL
VDGP
R
G
KDLR
AS
RAA
AE
NIIP
HT
TGAAKAIG
L
V
I
PEL
S
GKL
K
G
H
A
Q
RVP
V
K
TG
SV
T
E
L
V
S
I
L
G
K
K
VTAEEVN
N
ALK
Q
A
T
T
N
NES
-
-F
GYT
D
EE
I
VS
S
D
II
G
SHFG
SVFDATQ
T
EI
TAV
G
D
LQ
LVKTV
A
WYDNE
Y
GF
V
T
QL
IRTLEKFA
K
fig|331111.3.peg.4042
Escherichia coli E24377A (3-332/333)
KVGINGFGRIGR
L
V
L
RRL
L
E
--
V
K
S
N
I
D
VVAINDL
T
SP
KI
L
AYLLK
H
DS
N
Y
G
P
F
P
W
S
V
DFTE
D
S
LIV
D
GK
S
I
S
V
Y
AE
K
EAK
N
I
PW
K
A
K
G
AEII
V
ECTG
F
Y
T
S
A
E
KS
Q
AH
L
D
AGAKKVL
I
S
A
P
-
A
G
E
-MK
T
I
VY
N
VN
D
D
T
L
D
G
N
D
T
IVS
V
ASCTTNCLAP
M
AK
A
L
H
D
S
FGIE
V
GTMTTIHA
Y
T
G
TQ
SL
VDGP
R
G
KDLR
AS
RAA
AE
NIIP
HT
TGAAKAIG
L
V
I
PEL
S
GKL
K
G
H
A
Q
RVP
V
K
TG
SV
T
E
L
V
S
I
L
G
K
K
VTAEEVN
N
ALK
Q
A
T
T
N
NES
-
-F
GYT
D
EE
I
VS
S
D
II
G
SHFG
SVFDATQ
T
EI
TAV
G
D
LQ
LVKTV
A
WYDNE
Y
GF
V
T
QL
IRTLEKFA
K
fig|679204.3.peg.4218
Escherichia coli MS 145-7 (3-332/333)
KVGINGFGRIGR
L
V
L
RRL
L
E
--
V
K
S
N
I
D
VVAINDL
T
SP
KI
L
AYLLK
H
DS
N
Y
G
P
F
P
W
S
V
DFTE
D
S
LIV
D
GK
S
I
S
V
Y
AE
K
EAK
N
I
PW
K
A
K
G
AEII
V
ECTG
F
Y
T
S
A
E
KS
Q
AH
L
D
AGAKKVL
I
S
A
P
-
A
G
E
-MK
T
I
VY
N
VN
D
D
T
L
D
G
N
D
T
IVS
V
ASCTTNCLAP
M
AK
A
L
H
D
S
FGIE
V
GTMTTIHA
Y
T
G
TQ
SL
VDGP
R
G
KDLR
AS
RAA
AE
NIIP
HT
TGAAKAIG
L
V
I
PEL
S
GKL
K
G
H
A
Q
RVP
V
K
TG
SV
T
E
L
V
S
I
L
G
K
K
VTAEEVN
N
ALK
Q
A
T
T
N
NES
-
-F
GYT
D
EE
I
VS
S
D
II
G
SHFG
SVFDATQ
T
EI
TAV
G
D
LQ
LVKTV
A
WYDNE
Y
GF
V
T
QL
IRTLEKFA
K
fig|749545.3.peg.1108
Escherichia coli MS 182-1 (3-332/333)
KVGINGFGRIGR
L
V
L
RRL
L
E
--
V
K
S
N
I
D
VVAINDL
T
SP
KI
L
AYLLK
H
DS
N
Y
G
P
F
P
W
S
V
DFTE
D
S
LIV
D
GK
S
I
S
V
Y
AE
K
EAK
N
I
PW
K
A
K
G
AEII
V
ECTG
F
Y
T
S
A
E
KS
Q
AH
L
D
AGAKKVL
I
S
A
P
-
A
G
E
-MK
T
I
VY
N
VN
D
D
T
L
D
G
N
D
T
IVS
V
ASCTTNCLAP
M
AK
A
L
H
D
S
FGIE
V
GTMTTIHA
Y
T
G
TQ
SL
VDGP
R
G
KDLR
AS
RAA
AE
NIIP
HT
TGAAKAIG
L
V
I
PEL
S
GKL
K
G
H
A
Q
RVP
V
K
TG
SV
T
E
L
V
S
I
L
G
K
K
VTAEEVN
N
ALK
Q
A
T
T
N
NES
-
-F
GYT
D
EE
I
VS
S
D
II
G
SHFG
SVFDATQ
T
EI
TAV
G
D
LQ
LVKTV
A
WYDNE
Y
GF
V
T
QL
IRTLEKFA
K
fig|749532.3.peg.1699
Escherichia coli MS 78-1 (3-332/333)
KVGINGFGRIGR
L
V
L
RRL
L
E
--
V
K
S
N
I
D
VVAINDL
T
SP
KI
L
AYLLK
H
DS
N
Y
G
P
F
P
W
S
V
DFTE
D
S
LIV
D
GK
S
I
S
V
Y
AE
K
EAK
N
I
PW
K
A
K
G
AEII
V
ECTG
F
Y
T
S
A
E
KS
Q
AH
L
D
AGAKKVL
I
S
A
P
-
A
G
E
-MK
T
I
VY
N
VN
D
D
T
L
D
G
N
D
T
IVS
V
ASCTTNCLAP
M
AK
A
L
H
D
S
FGIE
V
GTMTTIHA
Y
T
G
TQ
SL
VDGP
R
G
KDLR
AS
RAA
AE
NIIP
HT
TGAAKAIG
L
V
I
PEL
S
GKL
K
G
H
A
Q
RVP
V
K
TG
SV
T
E
L
V
S
I
L
G
K
K
VTAEEVN
N
ALK
Q
A
T
T
N
NES
-
-F
GYT
D
EE
I
VS
S
D
II
G
SHFG
SVFDATQ
T
EI
TAV
G
D
LQ
LVKTV
A
WYDNE
Y
GF
V
T
QL
IRTLEKFA
K
fig|362663.8.peg.1433
Escherichia coli 536 (3-332/333)
KVGINGFGRIGR
L
V
L
RRL
L
E
--
V
K
S
N
I
D
VVAINDL
T
SP
KI
L
AYLLK
H
DS
N
Y
G
P
F
P
W
S
V
DYTE
D
S
LIV
D
GK
S
I
A
V
Y
AE
K
EAK
N
I
PW
K
A
K
G
AEII
V
ECTG
F
Y
T
S
A
E
KS
Q
AH
L
D
AGAKKVL
I
S
A
P
-
A
G
E
-MK
T
I
VY
N
VN
D
D
T
L
D
G
N
D
T
IVS
V
ASCTTNCLAP
M
AK
A
L
H
D
S
FGIE
V
GTMTTIHA
Y
T
G
TQ
SL
VDGP
R
G
KDLR
AS
RAA
AE
NIIP
HT
TGAAKAIG
L
V
I
PEL
S
GKL
K
G
H
A
Q
RVP
V
K
TG
SV
T
E
L
V
S
I
L
G
K
K
VTAEEVN
N
ALK
K
A
T
N
N
NES
-
-F
GYT
D
EE
I
VS
S
D
II
G
SHFG
SVFDATQ
T
EI
TAV
G
D
LQ
LVKTV
A
WYDNE
Y
GF
V
T
QL
IRTLEKFA
K
fig|362663.9.peg.1436
Escherichia coli 536 (3-332/333)
KVGINGFGRIGR
L
V
L
RRL
L
E
--
V
K
S
N
I
D
VVAINDL
T
SP
KI
L
AYLLK
H
DS
N
Y
G
P
F
P
W
S
V
DYTE
D
S
LIV
D
GK
S
I
A
V
Y
AE
K
EAK
N
I
PW
K
A
K
G
AEII
V
ECTG
F
Y
T
S
A
E
KS
Q
AH
L
D
AGAKKVL
I
S
A
P
-
A
G
E
-MK
T
I
VY
N
VN
D
D
T
L
D
G
N
D
T
IVS
V
ASCTTNCLAP
M
AK
A
L
H
D
S
FGIE
V
GTMTTIHA
Y
T
G
TQ
SL
VDGP
R
G
KDLR
AS
RAA
AE
NIIP
HT
TGAAKAIG
L
V
I
PEL
S
GKL
K
G
H
A
Q
RVP
V
K
TG
SV
T
E
L
V
S
I
L
G
K
K
VTAEEVN
N
ALK
K
A
T
N
N
NES
-
-F
GYT
D
EE
I
VS
S
D
II
G
SHFG
SVFDATQ
T
EI
TAV
G
D
LQ
LVKTV
A
WYDNE
Y
GF
V
T
QL
IRTLEKFA
K
fig|525281.3.peg.52
Escherichia coli 83972 (3-332/333)
KVGINGFGRIGR
L
V
L
RRL
L
E
--
V
K
S
N
I
D
VVAINDL
T
SP
KI
L
AYLLK
H
DS
N
Y
G
P
F
P
W
S
V
DYTE
D
S
LIV
D
GK
S
I
A
V
Y
AE
K
EAK
N
I
PW
K
A
K
G
AEII
V
ECTG
F
Y
T
S
A
E
KS
Q
AH
L
D
AGAKKVL
I
S
A
P
-
A
G
E
-MK
T
I
VY
N
VN
D
D
T
L
D
G
N
D
T
IVS
V
ASCTTNCLAP
M
AK
A
L
H
D
S
FGIE
V
GTMTTIHA
Y
T
G
TQ
SL
VDGP
R
G
KDLR
AS
RAA
AE
NIIP
HT
TGAAKAIG
L
V
I
PEL
S
GKL
K
G
H
A
Q
RVP
V
K
TG
SV
T
E
L
V
S
I
L
G
K
K
VTAEEVN
N
ALK
K
A
T
N
N
NES
-
-F
GYT
D
EE
I
VS
S
D
II
G
SHFG
SVFDATQ
T
EI
TAV
G
D
LQ
LVKTV
A
WYDNE
Y
GF
V
T
QL
IRTLEKFA
K
fig|655817.3.peg.1729
Escherichia coli ABU 83972 (3-332/333)
KVGINGFGRIGR
L
V
L
RRL
L
E
--
V
K
S
N
I
D
VVAINDL
T
SP
KI
L
AYLLK
H
DS
N
Y
G
P
F
P
W
S
V
DYTE
D
S
LIV
D
GK
S
I
A
V
Y
AE
K
EAK
N
I
PW
K
A
K
G
AEII
V
ECTG
F
Y
T
S
A
E
KS
Q
AH
L
D
AGAKKVL
I
S
A
P
-
A
G
E
-MK
T
I
VY
N
VN
D
D
T
L
D
G
N
D
T
IVS
V
ASCTTNCLAP
M
AK
A
L
H
D
S
FGIE
V
GTMTTIHA
Y
T
G
TQ
SL
VDGP
R
G
KDLR
AS
RAA
AE
NIIP
HT
TGAAKAIG
L
V
I
PEL
S
GKL
K
G
H
A
Q
RVP
V
K
TG
SV
T
E
L
V
S
I
L
G
K
K
VTAEEVN
N
ALK
K
A
T
N
N
NES
-
-F
GYT
D
EE
I
VS
S
D
II
G
SHFG
SVFDATQ
T
EI
TAV
G
D
LQ
LVKTV
A
WYDNE
Y
GF
V
T
QL
IRTLEKFA
K
fig|199310.1.peg.1787
Escherichia coli CFT073 (3-332/333)
KVGINGFGRIGR
L
V
L
RRL
L
E
--
V
K
S
N
I
D
VVAINDL
T
SP
KI
L
AYLLK
H
DS
N
Y
G
P
F
P
W
S
V
DYTE
D
S
LIV
D
GK
S
I
A
V
Y
AE
K
EAK
N
I
PW
K
A
K
G
AEII
V
ECTG
F
Y
T
S
A
E
KS
Q
AH
L
D
AGAKKVL
I
S
A
P
-
A
G
E
-MK
T
I
VY
N
VN
D
D
T
L
D
G
N
D
T
IVS
V
ASCTTNCLAP
M
AK
A
L
H
D
S
FGIE
V
GTMTTIHA
Y
T
G
TQ
SL
VDGP
R
G
KDLR
AS
RAA
AE
NIIP
HT
TGAAKAIG
L
V
I
PEL
S
GKL
K
G
H
A
Q
RVP
V
K
TG
SV
T
E
L
V
S
I
L
G
K
K
VTAEEVN
N
ALK
K
A
T
N
N
NES
-
-F
GYT
D
EE
I
VS
S
D
II
G
SHFG
SVFDATQ
T
EI
TAV
G
D
LQ
LVKTV
A
WYDNE
Y
GF
V
T
QL
IRTLEKFA
K
fig|199310.4.peg.1717
Escherichia coli CFT073 (3-332/333)
KVGINGFGRIGR
L
V
L
RRL
L
E
--
V
K
S
N
I
D
VVAINDL
T
SP
KI
L
AYLLK
H
DS
N
Y
G
P
F
P
W
S
V
DYTE
D
S
LIV
D
GK
S
I
A
V
Y
AE
K
EAK
N
I
PW
K
A
K
G
AEII
V
ECTG
F
Y
T
S
A
E
KS
Q
AH
L
D
AGAKKVL
I
S
A
P
-
A
G
E
-MK
T
I
VY
N
VN
D
D
T
L
D
G
N
D
T
IVS
V
ASCTTNCLAP
M
AK
A
L
H
D
S
FGIE
V
GTMTTIHA
Y
T
G
TQ
SL
VDGP
R
G
KDLR
AS
RAA
AE
NIIP
HT
TGAAKAIG
L
V
I
PEL
S
GKL
K
G
H
A
Q
RVP
V
K
TG
SV
T
E
L
V
S
I
L
G
K
K
VTAEEVN
N
ALK
K
A
T
N
N
NES
-
-F
GYT
D
EE
I
VS
S
D
II
G
SHFG
SVFDATQ
T
EI
TAV
G
D
LQ
LVKTV
A
WYDNE
Y
GF
V
T
QL
IRTLEKFA
K
fig|340197.3.peg.1197
Escherichia coli F11 (3-332/333)
KVGINGFGRIGR
L
V
L
RRL
L
E
--
V
K
S
N
I
D
VVAINDL
T
SP
KI
L
AYLLK
H
DS
N
Y
G
P
F
P
W
S
V
DYTE
D
S
LIV
D
GK
S
I
A
V
Y
AE
K
EAK
N
I
PW
K
A
K
G
AEII
V
ECTG
F
Y
T
S
A
E
KS
Q
AH
L
D
AGAKKVL
I
S
A
P
-
A
G
E
-MK
T
I
VY
N
VN
D
D
T
L
D
G
N
D
T
IVS
V
ASCTTNCLAP
M
AK
A
L
H
D
S
FGIE
V
GTMTTIHA
Y
T
G
TQ
SL
VDGP
R
G
KDLR
AS
RAA
AE
NIIP
HT
TGAAKAIG
L
V
I
PEL
S
GKL
K
G
H
A
Q
RVP
V
K
TG
SV
T
E
L
V
S
I
L
G
K
K
VTAEEVN
N
ALK
K
A
T
N
N
NES
-
-F
GYT
D
EE
I
VS
S
D
II
G
SHFG
SVFDATQ
T
EI
TAV
G
D
LQ
LVKTV
A
WYDNE
Y
GF
V
T
QL
IRTLEKFA
K
fig|340197.5.peg.1261
Escherichia coli F11 (3-332/333)
KVGINGFGRIGR
L
V
L
RRL
L
E
--
V
K
S
N
I
D
VVAINDL
T
SP
KI
L
AYLLK
H
DS
N
Y
G
P
F
P
W
S
V
DYTE
D
S
LIV
D
GK
S
I
A
V
Y
AE
K
EAK
N
I
PW
K
A
K
G
AEII
V
ECTG
F
Y
T
S
A
E
KS
Q
AH
L
D
AGAKKVL
I
S
A
P
-
A
G
E
-MK
T
I
VY
N
VN
D
D
T
L
D
G
N
D
T
IVS
V
ASCTTNCLAP
M
AK
A
L
H
D
S
FGIE
V
GTMTTIHA
Y
T
G
TQ
SL
VDGP
R
G
KDLR
AS
RAA
AE
NIIP
HT
TGAAKAIG
L
V
I
PEL
S
GKL
K
G
H
A
Q
RVP
V
K
TG
SV
T
E
L
V
S
I
L
G
K
K
VTAEEVN
N
ALK
K
A
T
N
N
NES
-
-F
GYT
D
EE
I
VS
S
D
II
G
SHFG
SVFDATQ
T
EI
TAV
G
D
LQ
LVKTV
A
WYDNE
Y
GF
V
T
QL
IRTLEKFA
K
fig|749546.3.peg.726
Escherichia coli MS 185-1 (3-332/333)
KVGINGFGRIGR
L
V
L
RRL
L
E
--
V
K
S
N
I
D
VVAINDL
T
SP
KI
L
AYLLK
H
DS
N
Y
G
P
F
P
W
S
V
DYTE
D
S
LIV
D
GK
S
I
A
V
Y
AE
K
EAK
N
I
PW
K
A
K
G
AEII
V
ECTG
F
Y
T
S
A
E
KS
Q
AH
L
D
AGAKKVL
I
S
A
P
-
A
G
E
-MK
T
I
VY
N
VN
D
D
T
L
D
G
N
D
T
IVS
V
ASCTTNCLAP
M
AK
A
L
H
D
S
FGIE
V
GTMTTIHA
Y
T
G
TQ
SL
VDGP
R
G
KDLR
AS
RAA
AE
NIIP
HT
TGAAKAIG
L
V
I
PEL
S
GKL
K
G
H
A
Q
RVP
V
K
TG
SV
T
E
L
V
S
I
L
G
K
K
VTAEEVN
N
ALK
K
A
T
N
N
NES
-
-F
GYT
D
EE
I
VS
S
D
II
G
SHFG
SVFDATQ
T
EI
TAV
G
D
LQ
LVKTV
A
WYDNE
Y
GF
V
T
QL
IRTLEKFA
K
fig|749550.3.peg.203
Escherichia coli MS 200-1 (3-332/333)
KVGINGFGRIGR
L
V
L
RRL
L
E
--
V
K
S
N
I
D
VVAINDL
T
SP
KI
L
AYLLK
H
DS
N
Y
G
P
F
P
W
S
V
DYTE
D
S
LIV
D
GK
S
I
A
V
Y
AE
K
EAK
N
I
PW
K
A
K
G
AEII
V
ECTG
F
Y
T
S
A
E
KS
Q
AH
L
D
AGAKKVL
I
S
A
P
-
A
G
E
-MK
T
I
VY
N
VN
D
D
T
L
D
G
N
D
T
IVS
V
ASCTTNCLAP
M
AK
A
L
H
D
S
FGIE
V
GTMTTIHA
Y
T
G
TQ
SL
VDGP
R
G
KDLR
AS
RAA
AE
NIIP
HT
TGAAKAIG
L
V
I
PEL
S
GKL
K
G
H
A
Q
RVP
V
K
TG
SV
T
E
L
V
S
I
L
G
K
K
VTAEEVN
N
ALK
K
A
T
N
N
NES
-
-F
GYT
D
EE
I
VS
S
D
II
G
SHFG
SVFDATQ
T
EI
TAV
G
D
LQ
LVKTV
A
WYDNE
Y
GF
V
T
QL
IRTLEKFA
K
fig|749528.3.peg.1166
Escherichia coli MS 45-1 (3-332/333)
KVGINGFGRIGR
L
V
L
RRL
L
E
--
V
K
S
N
I
D
VVAINDL
T
SP
KI
L
AYLLK
H
DS
N
Y
G
P
F
P
W
S
V
DYTE
D
S
LIV
D
GK
S
I
A
V
Y
AE
K
EAK
N
I
PW
K
A
K
G
AEII
V
ECTG
F
Y
T
S
A
E
KS
Q
AH
L
D
AGAKKVL
I
S
A
P
-
A
G
E
-MK
T
I
VY
N
VN
D
D
T
L
D
G
N
D
T
IVS
V
ASCTTNCLAP
M
AK
A
L
H
D
S
FGIE
V
GTMTTIHA
Y
T
G
TQ
SL
VDGP
R
G
KDLR
AS
RAA
AE
NIIP
HT
TGAAKAIG
L
V
I
PEL
S
GKL
K
G
H
A
Q
RVP
V
K
TG
SV
T
E
L
V
S
I
L
G
K
K
VTAEEVN
N
ALK
K
A
T
N
N
NES
-
-F
GYT
D
EE
I
VS
S
D
II
G
SHFG
SVFDATQ
T
EI
TAV
G
D
LQ
LVKTV
A
WYDNE
Y
GF
V
T
QL
IRTLEKFA
K
fig|685038.3.peg.1411
Escherichia coli O83:H1 str. NRG 857C (3-332/333)
KVGINGFGRIGR
L
V
L
RRL
L
E
--
V
K
S
N
I
D
VVAINDL
T
SP
KI
L
AYLLK
H
DS
N
Y
G
P
F
P
W
S
V
DYTE
D
S
LIV
D
GK
S
I
A
V
Y
AE
K
EAK
N
I
PW
K
A
K
G
AEII
V
ECTG
F
Y
T
S
A
E
KS
Q
AH
L
D
AGAKKVL
I
S
A
P
-
A
G
E
-MK
T
I
VY
N
VN
D
D
T
L
D
G
N
D
T
IVS
V
ASCTTNCLAP
M
AK
A
L
H
D
S
FGIE
V
GTMTTIHA
Y
T
G
TQ
SL
VDGP
R
G
KDLR
AS
RAA
AE
NIIP
HT
TGAAKAIG
L
V
I
PEL
S
GKL
K
G
H
A
Q
RVP
V
K
TG
SV
T
E
L
V
S
I
L
G
K
K
VTAEEVN
N
ALK
K
A
T
N
N
NES
-
-F
GYT
D
EE
I
VS
S
D
II
G
SHFG
SVFDATQ
T
EI
TAV
G
D
LQ
LVKTV
A
WYDNE
Y
GF
V
T
QL
IRTLEKFA
K
fig|431946.3.peg.1397
Escherichia coli SE15 (3-332/333)
KVGINGFGRIGR
L
V
L
RRL
L
E
--
V
K
S
N
I
D
VVAINDL
T
SP
KI
L
AYLLK
H
DS
N
Y
G
P
F
P
W
S
V
DYTE
D
S
LIV
D
GK
S
I
A
V
Y
AE
K
EAK
N
I
PW
K
A
K
G
AEII
V
ECTG
F
Y
T
S
A
E
KS
Q
AH
L
D
AGAKKVL
I
S
A
P
-
A
G
E
-MK
T
I
VY
N
VN
D
D
T
L
D
G
N
D
T
IVS
V
ASCTTNCLAP
M
AK
A
L
H
D
S
FGIE
V
GTMTTIHA
Y
T
G
TQ
SL
VDGP
R
G
KDLR
AS
RAA
AE
NIIP
HT
TGAAKAIG
L
V
I
PEL
S
GKL
K
G
H
A
Q
RVP
V
K
TG
SV
T
E
L
V
S
I
L
G
K
K
VTAEEVN
N
ALK
K
A
T
N
N
NES
-
-F
GYT
D
EE
I
VS
S
D
II
G
SHFG
SVFDATQ
T
EI
TAV
G
D
LQ
LVKTV
A
WYDNE
Y
GF
V
T
QL
IRTLEKFA
K
fig|562.376.peg.3088
Escherichia coli WV_060327 (3-332/333)
KVGINGFGRIGR
L
V
L
RRL
L
E
--
V
K
S
N
I
D
VVAINDL
T
SP
KI
L
AYLLK
H
DS
N
Y
G
P
F
P
W
S
V
DYTE
D
S
LIV
D
GK
S
I
A
V
Y
AE
K
EAK
N
I
PW
K
A
K
G
AEII
V
ECTG
F
Y
T
S
A
E
KS
Q
AH
L
D
AGAKKVL
I
S
A
P
-
A
G
E
-MK
T
I
VY
N
VN
D
D
T
L
D
G
N
D
T
IVS
V
ASCTTNCLAP
M
AK
A
L
H
D
S
FGIE
V
GTMTTIHA
Y
T
G
TQ
SL
VDGP
R
G
KDLR
AS
RAA
AE
NIIP
HT
TGAAKAIG
L
V
I
PEL
S
GKL
K
G
H
A
Q
RVP
V
K
TG
SV
T
E
L
V
S
I
L
G
K
K
VTAEEVN
N
ALK
K
A
T
N
N
NES
-
-F
GYT
D
EE
I
VS
S
D
II
G
SHFG
SVFDATQ
T
EI
TAV
G
D
LQ
LVKTV
A
WYDNE
Y
GF
V
T
QL
IRTLEKFA
K
fig|316401.4.peg.1708
Escherichia coli ETEC H10407 (3-332/333)
KVGINGFGRIGR
L
V
L
RRL
L
E
--
V
K
S
N
I
D
VVAINDL
T
SP
KI
L
AYLLK
H
DS
N
Y
G
P
F
P
W
S
V
DFTE
D
S
LIV
D
GK
S
I
A
V
Y
AE
K
EAK
N
I
PW
K
A
K
G
T
EII
V
ECTG
F
Y
T
S
A
E
KS
Q
AH
L
D
AGAKKVL
I
S
A
P
-
A
G
E
-MK
T
I
VY
N
VN
D
D
T
L
D
G
N
D
T
IVS
V
ASCTTNCLAP
M
AK
A
L
H
D
S
FGIE
V
GTMTTIHA
Y
T
G
TQ
SL
VDGP
R
G
KDLR
AS
RAA
AE
NIIP
HT
TGAAKAIG
L
V
I
PEL
S
GKL
K
G
H
A
Q
RVP
V
K
TG
SV
T
E
L
V
S
I
L
G
K
K
VTAEEVN
N
ALK
Q
A
T
T
N
NES
-
-F
GYT
D
EE
I
VS
S
D
II
G
SHFG
SVFDATQ
T
EI
TAV
G
D
LQ
LVKTV
A
WYDNE
Y
GF
V
T
QL
IRTLEKFA
K
fig|1040638.4.peg.4155
Escherichia coli O104:H4 str. LB226692 (3-332/333)
KVGINGFGRIGR
L
V
L
RRL
L
E
--
V
K
S
N
I
D
VVAINDL
T
SP
KI
L
AYLLK
H
DS
N
Y
G
P
F
P
W
S
V
DFTE
D
S
LIV
D
GK
S
I
A
V
Y
AE
K
EAK
N
I
PW
K
A
K
G
AEII
V
ECTG
F
Y
T
S
A
E
KS
Q
AH
L
D
AGAKKVL
I
S
A
P
-
A
G
E
-MK
T
I
VY
N
VN
D
D
T
L
D
G
N
D
T
IVS
V
ASCTTNCLAP
M
AK
A
L
H
D
S
FGIE
V
GTMTTIHA
Y
T
G
TQ
SL
VDGP
R
G
KDLR
AS
RAA
AE
NIIP
HT
TGAAKAIG
L
V
I
PEL
S
GKL
K
G
H
A
Q
RVP
V
K
TG
SV
T
E
L
V
S
I
L
G
K
K
VTAEEVN
N
ALK
Q
A
T
T
N
NES
-
-F
GYT
D
EE
I
VS
S
D
II
G
SHFG
SVFDATQ
T
EI
TAV
G
D
LQ
LVKTV
A
WYDNE
Y
GF
V
T
QL
IRTLEKFA
K
fig|6666666.5357.peg.3617
Escherichia coli TY-2482 (3-332/333)
KVGINGFGRIGR
L
V
L
RRL
L
E
--
V
K
S
N
I
D
VVAINDL
T
SP
KI
L
AYLLK
H
DS
N
Y
G
P
F
P
W
S
V
DFTE
D
S
LIV
D
GK
S
I
A
V
Y
AE
K
EAK
N
I
PW
K
A
K
G
AEII
V
ECTG
F
Y
T
S
A
E
KS
Q
AH
L
D
AGAKKVL
I
S
A
P
-
A
G
E
-MK
T
I
VY
N
VN
D
D
T
L
D
G
N
D
T
IVS
V
ASCTTNCLAP
M
AK
A
L
H
D
S
FGIE
V
GTMTTIHA
Y
T
G
TQ
SL
VDGP
R
G
KDLR
AS
RAA
AE
NIIP
HT
TGAAKAIG
L
V
I
PEL
S
GKL
K
G
H
A
Q
RVP
V
K
TG
SV
T
E
L
V
S
I
L
G
K
K
VTAEEVN
N
ALK
Q
A
T
T
N
NES
-
-F
GYT
D
EE
I
VS
S
D
II
G
SHFG
SVFDATQ
T
EI
TAV
G
D
LQ
LVKTV
A
WYDNE
Y
GF
V
T
QL
IRTLEKFA
K
fig|358709.5.peg.903
Escherichia coli 101-1 (3-332/333)
KVGINGFGRIGR
L
V
L
RRL
L
E
--
V
K
S
N
I
D
VVAINDL
T
SP
KI
L
AYLLK
H
DS
N
Y
G
P
F
P
W
S
V
DFTE
D
S
LIV
D
GK
S
I
A
V
Y
AE
K
EAK
N
I
PW
K
A
K
G
AEII
V
ECTG
F
Y
T
S
A
E
KS
Q
AH
L
D
AGAKKVL
I
S
A
P
-
A
G
E
-MK
T
I
VY
N
VN
D
D
T
L
D
G
N
D
T
IVS
V
ASCTTNCLAP
M
AK
A
L
H
D
S
FGIE
V
GTMTTIHA
Y
T
G
TQ
SL
VDGP
R
G
KDLR
AS
RAA
AE
NIIP
HT
TGAAKAIG
L
V
I
PEL
S
GKL
K
G
H
A
Q
RVP
V
K
TG
SV
T
E
L
V
S
I
L
G
K
K
VTAEEVN
N
ALK
Q
A
T
T
N
NES
-
-F
GYT
D
EE
I
VS
S
D
II
G
SHFG
SVFDATQ
T
EI
TAV
G
D
LQ
LVKTV
A
WYDNE
Y
GF
V
T
QL
IRTLEKFA
K
fig|670888.3.peg.2082
Escherichia coli 1827-70 (3-332/333)
KVGINGFGRIGR
L
V
L
RRL
L
E
--
V
K
S
N
I
D
VVAINDL
T
SP
KI
L
AYLLK
H
DS
N
Y
G
P
F
P
W
S
V
DFTE
D
S
LIV
D
GK
S
I
A
V
Y
AE
K
EAK
N
I
PW
K
A
K
G
AEII
V
ECTG
F
Y
T
S
A
E
KS
Q
AH
L
D
AGAKKVL
I
S
A
P
-
A
G
E
-MK
T
I
VY
N
VN
D
D
T
L
D
G
N
D
T
IVS
V
ASCTTNCLAP
M
AK
A
L
H
D
S
FGIE
V
GTMTTIHA
Y
T
G
TQ
SL
VDGP
R
G
KDLR
AS
RAA
AE
NIIP
HT
TGAAKAIG
L
V
I
PEL
S
GKL
K
G
H
A
Q
RVP
V
K
TG
SV
T
E
L
V
S
I
L
G
K
K
VTAEEVN
N
ALK
Q
A
T
T
N
NES
-
-F
GYT
D
EE
I
VS
S
D
II
G
SHFG
SVFDATQ
T
EI
TAV
G
D
LQ
LVKTV
A
WYDNE
Y
GF
V
T
QL
IRTLEKFA
K
fig|344610.3.peg.1085
Escherichia coli 53638 (3-332/333)
KVGINGFGRIGR
L
V
L
RRL
L
E
--
V
K
S
N
I
D
VVAINDL
T
SP
KI
L
AYLLK
H
DS
N
Y
G
P
F
P
W
S
V
DFTE
D
S
LIV
D
GK
S
I
A
V
Y
AE
K
EAK
N
I
PW
K
A
K
G
AEII
V
ECTG
F
Y
T
S
A
E
KS
Q
AH
L
D
AGAKKVL
I
S
A
P
-
A
G
E
-MK
T
I
VY
N
VN
D
D
T
L
D
G
N
D
T
IVS
V
ASCTTNCLAP
M
AK
A
L
H
D
S
FGIE
V
GTMTTIHA
Y
T
G
TQ
SL
VDGP
R
G
KDLR
AS
RAA
AE
NIIP
HT
TGAAKAIG
L
V
I
PEL
S
GKL
K
G
H
A
Q
RVP
V
K
TG
SV
T
E
L
V
S
I
L
G
K
K
VTAEEVN
N
ALK
Q
A
T
T
N
NES
-
-F
GYT
D
EE
I
VS
S
D
II
G
SHFG
SVFDATQ
T
EI
TAV
G
D
LQ
LVKTV
A
WYDNE
Y
GF
V
T
QL
IRTLEKFA
K
fig|344610.7.peg.5076
Escherichia coli 53638 (3-332/333)
KVGINGFGRIGR
L
V
L
RRL
L
E
--
V
K
S
N
I
D
VVAINDL
T
SP
KI
L
AYLLK
H
DS
N
Y
G
P
F
P
W
S
V
DFTE
D
S
LIV
D
GK
S
I
A
V
Y
AE
K
EAK
N
I
PW
K
A
K
G
AEII
V
ECTG
F
Y
T
S
A
E
KS
Q
AH
L
D
AGAKKVL
I
S
A
P
-
A
G
E
-MK
T
I
VY
N
VN
D
D
T
L
D
G
N
D
T
IVS
V
ASCTTNCLAP
M
AK
A
L
H
D
S
FGIE
V
GTMTTIHA
Y
T
G
TQ
SL
VDGP
R
G
KDLR
AS
RAA
AE
NIIP
HT
TGAAKAIG
L
V
I
PEL
S
GKL
K
G
H
A
Q
RVP
V
K
TG
SV
T
E
L
V
S
I
L
G
K
K
VTAEEVN
N
ALK
Q
A
T
T
N
NES
-
-F
GYT
D
EE
I
VS
S
D
II
G
SHFG
SVFDATQ
T
EI
TAV
G
D
LQ
LVKTV
A
WYDNE
Y
GF
V
T
QL
IRTLEKFA
K
fig|585055.6.peg.1577
Escherichia coli 55989 (3-332/333)
KVGINGFGRIGR
L
V
L
RRL
L
E
--
V
K
S
N
I
D
VVAINDL
T
SP
KI
L
AYLLK
H
DS
N
Y
G
P
F
P
W
S
V
DFTE
D
S
LIV
D
GK
S
I
A
V
Y
AE
K
EAK
N
I
PW
K
A
K
G
AEII
V
ECTG
F
Y
T
S
A
E
KS
Q
AH
L
D
AGAKKVL
I
S
A
P
-
A
G
E
-MK
T
I
VY
N
VN
D
D
T
L
D
G
N
D
T
IVS
V
ASCTTNCLAP
M
AK
A
L
H
D
S
FGIE
V
GTMTTIHA
Y
T
G
TQ
SL
VDGP
R
G
KDLR
AS
RAA
AE
NIIP
HT
TGAAKAIG
L
V
I
PEL
S
GKL
K
G
H
A
Q
RVP
V
K
TG
SV
T
E
L
V
S
I
L
G
K
K
VTAEEVN
N
ALK
Q
A
T
T
N
NES
-
-F
GYT
D
EE
I
VS
S
D
II
G
SHFG
SVFDATQ
T
EI
TAV
G
D
LQ
LVKTV
A
WYDNE
Y
GF
V
T
QL
IRTLEKFA
K
fig|585055.8.peg.1579
Escherichia coli 55989 (3-332/333)
KVGINGFGRIGR
L
V
L
RRL
L
E
--
V
K
S
N
I
D
VVAINDL
T
SP
KI
L
AYLLK
H
DS
N
Y
G
P
F
P
W
S
V
DFTE
D
S
LIV
D
GK
S
I
A
V
Y
AE
K
EAK
N
I
PW
K
A
K
G
AEII
V
ECTG
F
Y
T
S
A
E
KS
Q
AH
L
D
AGAKKVL
I
S
A
P
-
A
G
E
-MK
T
I
VY
N
VN
D
D
T
L
D
G
N
D
T
IVS
V
ASCTTNCLAP
M
AK
A
L
H
D
S
FGIE
V
GTMTTIHA
Y
T
G
TQ
SL
VDGP
R
G
KDLR
AS
RAA
AE
NIIP
HT
TGAAKAIG
L
V
I
PEL
S
GKL
K
G
H
A
Q
RVP
V
K
TG
SV
T
E
L
V
S
I
L
G
K
K
VTAEEVN
N
ALK
Q
A
T
T
N
NES
-
-F
GYT
D
EE
I
VS
S
D
II
G
SHFG
SVFDATQ
T
EI
TAV
G
D
LQ
LVKTV
A
WYDNE
Y
GF
V
T
QL
IRTLEKFA
K
fig|481805.3.peg.2407
Escherichia coli ATCC 8739 (3-332/333)
KVGINGFGRIGR
L
V
L
RRL
L
E
--
V
K
S
N
I
D
VVAINDL
T
SP
KI
L
AYLLK
H
DS
N
Y
G
P
F
P
W
S
V
DFTE
D
S
LIV
D
GK
S
I
A
V
Y
AE
K
EAK
N
I
PW
K
A
K
G
AEII
V
ECTG
F
Y
T
S
A
E
KS
Q
AH
L
D
AGAKKVL
I
S
A
P
-
A
G
E
-MK
T
I
VY
N
VN
D
D
T
L
D
G
N
D
T
IVS
V
ASCTTNCLAP
M
AK
A
L
H
D
S
FGIE
V
GTMTTIHA
Y
T
G
TQ
SL
VDGP
R
G
KDLR
AS
RAA
AE
NIIP
HT
TGAAKAIG
L
V
I
PEL
S
GKL
K
G
H
A
Q
RVP
V
K
TG
SV
T
E
L
V
S
I
L
G
K
K
VTAEEVN
N
ALK
Q
A
T
T
N
NES
-
-F
GYT
D
EE
I
VS
S
D
II
G
SHFG
SVFDATQ
T
EI
TAV
G
D
LQ
LVKTV
A
WYDNE
Y
GF
V
T
QL
IRTLEKFA
K
fig|481805.6.peg.2396
Escherichia coli ATCC 8739 (3-332/333)
KVGINGFGRIGR
L
V
L
RRL
L
E
--
V
K
S
N
I
D
VVAINDL
T
SP
KI
L
AYLLK
H
DS
N
Y
G
P
F
P
W
S
V
DFTE
D
S
LIV
D
GK
S
I
A
V
Y
AE
K
EAK
N
I
PW
K
A
K
G
AEII
V
ECTG
F
Y
T
S
A
E
KS
Q
AH
L
D
AGAKKVL
I
S
A
P
-
A
G
E
-MK
T
I
VY
N
VN
D
D
T
L
D
G
N
D
T
IVS
V
ASCTTNCLAP
M
AK
A
L
H
D
S
FGIE
V
GTMTTIHA
Y
T
G
TQ
SL
VDGP
R
G
KDLR
AS
RAA
AE
NIIP
HT
TGAAKAIG
L
V
I
PEL
S
GKL
K
G
H
A
Q
RVP
V
K
TG
SV
T
E
L
V
S
I
L
G
K
K
VTAEEVN
N
ALK
Q
A
T
T
N
NES
-
-F
GYT
D
EE
I
VS
S
D
II
G
SHFG
SVFDATQ
T
EI
TAV
G
D
LQ
LVKTV
A
WYDNE
Y
GF
V
T
QL
IRTLEKFA
K
fig|413997.3.peg.1444
Escherichia coli B str. REL606 (3-332/333)
KVGINGFGRIGR
L
V
L
RRL
L
E
--
V
K
S
N
I
D
VVAINDL
T
SP
KI
L
AYLLK
H
DS
N
Y
G
P
F
P
W
S
V
DFTE
D
S
LIV
D
GK
S
I
A
V
Y
AE
K
EAK
N
I
PW
K
A
K
G
AEII
V
ECTG
F
Y
T
S
A
E
KS
Q
AH
L
D
AGAKKVL
I
S
A
P
-
A
G
E
-MK
T
I
VY
N
VN
D
D
T
L
D
G
N
D
T
IVS
V
ASCTTNCLAP
M
AK
A
L
H
D
S
FGIE
V
GTMTTIHA
Y
T
G
TQ
SL
VDGP
R
G
KDLR
AS
RAA
AE
NIIP
HT
TGAAKAIG
L
V
I
PEL
S
GKL
K
G
H
A
Q
RVP
V
K
TG
SV
T
E
L
V
S
I
L
G
K
K
VTAEEVN
N
ALK
Q
A
T
T
N
NES
-
-F
GYT
D
EE
I
VS
S
D
II
G
SHFG
SVFDATQ
T
EI
TAV
G
D
LQ
LVKTV
A
WYDNE
Y
GF
V
T
QL
IRTLEKFA
K
fig|511693.5.peg.1483
Escherichia coli BL21 (3-332/333)
KVGINGFGRIGR
L
V
L
RRL
L
E
--
V
K
S
N
I
D
VVAINDL
T
SP
KI
L
AYLLK
H
DS
N
Y
G
P
F
P
W
S
V
DFTE
D
S
LIV
D
GK
S
I
A
V
Y
AE
K
EAK
N
I
PW
K
A
K
G
AEII
V
ECTG
F
Y
T
S
A
E
KS
Q
AH
L
D
AGAKKVL
I
S
A
P
-
A
G
E
-MK
T
I
VY
N
VN
D
D
T
L
D
G
N
D
T
IVS
V
ASCTTNCLAP
M
AK
A
L
H
D
S
FGIE
V
GTMTTIHA
Y
T
G
TQ
SL
VDGP
R
G
KDLR
AS
RAA
AE
NIIP
HT
TGAAKAIG
L
V
I
PEL
S
GKL
K
G
H
A
Q
RVP
V
K
TG
SV
T
E
L
V
S
I
L
G
K
K
VTAEEVN
N
ALK
Q
A
T
T
N
NES
-
-F
GYT
D
EE
I
VS
S
D
II
G
SHFG
SVFDATQ
T
EI
TAV
G
D
LQ
LVKTV
A
WYDNE
Y
GF
V
T
QL
IRTLEKFA
K
fig|469008.4.peg.2291
Escherichia coli BL21(DE3) (3-332/333)
KVGINGFGRIGR
L
V
L
RRL
L
E
--
V
K
S
N
I
D
VVAINDL
T
SP
KI
L
AYLLK
H
DS
N
Y
G
P
F
P
W
S
V
DFTE
D
S
LIV
D
GK
S
I
A
V
Y
AE
K
EAK
N
I
PW
K
A
K
G
AEII
V
ECTG
F
Y
T
S
A
E
KS
Q
AH
L
D
AGAKKVL
I
S
A
P
-
A
G
E
-MK
T
I
VY
N
VN
D
D
T
L
D
G
N
D
T
IVS
V
ASCTTNCLAP
M
AK
A
L
H
D
S
FGIE
V
GTMTTIHA
Y
T
G
TQ
SL
VDGP
R
G
KDLR
AS
RAA
AE
NIIP
HT
TGAAKAIG
L
V
I
PEL
S
GKL
K
G
H
A
Q
RVP
V
K
TG
SV
T
E
L
V
S
I
L
G
K
K
VTAEEVN
N
ALK
Q
A
T
T
N
NES
-
-F
GYT
D
EE
I
VS
S
D
II
G
SHFG
SVFDATQ
T
EI
TAV
G
D
LQ
LVKTV
A
WYDNE
Y
GF
V
T
QL
IRTLEKFA
K
fig|340185.3.peg.1049
Escherichia coli E22 (3-332/333)
KVGINGFGRIGR
L
V
L
RRL
L
E
--
V
K
S
N
I
D
VVAINDL
T
SP
KI
L
AYLLK
H
DS
N
Y
G
P
F
P
W
S
V
DFTE
D
S
LIV
D
GK
S
I
A
V
Y
AE
K
EAK
N
I
PW
K
A
K
G
AEII
V
ECTG
F
Y
T
S
A
E
KS
Q
AH
L
D
AGAKKVL
I
S
A
P
-
A
G
E
-MK
T
I
VY
N
VN
D
D
T
L
D
G
N
D
T
IVS
V
ASCTTNCLAP
M
AK
A
L
H
D
S
FGIE
V
GTMTTIHA
Y
T
G
TQ
SL
VDGP
R
G
KDLR
AS
RAA
AE
NIIP
HT
TGAAKAIG
L
V
I
PEL
S
GKL
K
G
H
A
Q
RVP
V
K
TG
SV
T
E
L
V
S
I
L
G
K
K
VTAEEVN
N
ALK
Q
A
T
T
N
NES
-
-F
GYT
D
EE
I
VS
S
D
II
G
SHFG
SVFDATQ
T
EI
TAV
G
D
LQ
LVKTV
A
WYDNE
Y
GF
V
T
QL
IRTLEKFA
K
fig|340185.4.peg.1101
Escherichia coli E22 (3-332/333)
KVGINGFGRIGR
L
V
L
RRL
L
E
--
V
K
S
N
I
D
VVAINDL
T
SP
KI
L
AYLLK
H
DS
N
Y
G
P
F
P
W
S
V
DFTE
D
S
LIV
D
GK
S
I
A
V
Y
AE
K
EAK
N
I
PW
K
A
K
G
AEII
V
ECTG
F
Y
T
S
A
E
KS
Q
AH
L
D
AGAKKVL
I
S
A
P
-
A
G
E
-MK
T
I
VY
N
VN
D
D
T
L
D
G
N
D
T
IVS
V
ASCTTNCLAP
M
AK
A
L
H
D
S
FGIE
V
GTMTTIHA
Y
T
G
TQ
SL
VDGP
R
G
KDLR
AS
RAA
AE
NIIP
HT
TGAAKAIG
L
V
I
PEL
S
GKL
K
G
H
A
Q
RVP
V
K
TG
SV
T
E
L
V
S
I
L
G
K
K
VTAEEVN
N
ALK
Q
A
T
T
N
NES
-
-F
GYT
D
EE
I
VS
S
D
II
G
SHFG
SVFDATQ
T
EI
TAV
G
D
LQ
LVKTV
A
WYDNE
Y
GF
V
T
QL
IRTLEKFA
K
fig|562.375.peg.4297
Escherichia coli EC4100B (3-332/333)
KVGINGFGRIGR
L
V
L
RRL
L
E
--
V
K
S
N
I
D
VVAINDL
T
SP
KI
L
AYLLK
H
DS
N
Y
G
P
F
P
W
S
V
DFTE
D
S
LIV
D
GK
S
I
A
V
Y
AE
K
EAK
N
I
PW
K
A
K
G
AEII
V
ECTG
F
Y
T
S
A
E
KS
Q
AH
L
D
AGAKKVL
I
S
A
P
-
A
G
E
-MK
T
I
VY
N
VN
D
D
T
L
D
G
N
D
T
IVS
V
ASCTTNCLAP
M
AK
A
L
H
D
S
FGIE
V
GTMTTIHA
Y
T
G
TQ
SL
VDGP
R
G
KDLR
AS
RAA
AE
NIIP
HT
TGAAKAIG
L
V
I
PEL
S
GKL
K
G
H
A
Q
RVP
V
K
TG
SV
T
E
L
V
S
I
L
G
K
K
VTAEEVN
N
ALK
Q
A
T
T
N
NES
-
-F
GYT
D
EE
I
VS
S
D
II
G
SHFG
SVFDATQ
T
EI
TAV
G
D
LQ
LVKTV
A
WYDNE
Y
GF
V
T
QL
IRTLEKFA
K
fig|656408.3.peg.1547
Escherichia coli H591 (3-332/333)
KVGINGFGRIGR
L
V
L
RRL
L
E
--
V
K
S
N
I
D
VVAINDL
T
SP
KI
L
AYLLK
H
DS
N
Y
G
P
F
P
W
S
V
DFTE
D
S
LIV
D
GK
S
I
A
V
Y
AE
K
EAK
N
I
PW
K
A
K
G
AEII
V
ECTG
F
Y
T
S
A
E
KS
Q
AH
L
D
AGAKKVL
I
S
A
P
-
A
G
E
-MK
T
I
VY
N
VN
D
D
T
L
D
G
N
D
T
IVS
V
ASCTTNCLAP
M
AK
A
L
H
D
S
FGIE
V
GTMTTIHA
Y
T
G
TQ
SL
VDGP
R
G
KDLR
AS
RAA
AE
NIIP
HT
TGAAKAIG
L
V
I
PEL
S
GKL
K
G
H
A
Q
RVP
V
K
TG
SV
T
E
L
V
S
I
L
G
K
K
VTAEEVN
N
ALK
Q
A
T
T
N
NES
-
-F
GYT
D
EE
I
VS
S
D
II
G
SHFG
SVFDATQ
T
EI
TAV
G
D
LQ
LVKTV
A
WYDNE
Y
GF
V
T
QL
IRTLEKFA
K
fig|331112.3.peg.1408
Escherichia coli HS (3-332/333)
KVGINGFGRIGR
L
V
L
RRL
L
E
--
V
K
S
N
I
D
VVAINDL
T
SP
KI
L
AYLLK
H
DS
N
Y
G
P
F
P
W
S
V
DFTE
D
S
LIV
D
GK
S
I
A
V
Y
AE
K
EAK
N
I
PW
K
A
K
G
AEII
V
ECTG
F
Y
T
S
A
E
KS
Q
AH
L
D
AGAKKVL
I
S
A
P
-
A
G
E
-MK
T
I
VY
N
VN
D
D
T
L
D
G
N
D
T
IVS
V
ASCTTNCLAP
M
AK
A
L
H
D
S
FGIE
V
GTMTTIHA
Y
T
G
TQ
SL
VDGP
R
G
KDLR
AS
RAA
AE
NIIP
HT
TGAAKAIG
L
V
I
PEL
S
GKL
K
G
H
A
Q
RVP
V
K
TG
SV
T
E
L
V
S
I
L
G
K
K
VTAEEVN
N
ALK
Q
A
T
T
N
NES
-
-F
GYT
D
EE
I
VS
S
D
II
G
SHFG
SVFDATQ
T
EI
TAV
G
D
LQ
LVKTV
A
WYDNE
Y
GF
V
T
QL
IRTLEKFA
K
fig|331112.6.peg.1466
Escherichia coli HS (3-332/333)
KVGINGFGRIGR
L
V
L
RRL
L
E
--
V
K
S
N
I
D
VVAINDL
T
SP
KI
L
AYLLK
H
DS
N
Y
G
P
F
P
W
S
V
DFTE
D
S
LIV
D
GK
S
I
A
V
Y
AE
K
EAK
N
I
PW
K
A
K
G
AEII
V
ECTG
F
Y
T
S
A
E
KS
Q
AH
L
D
AGAKKVL
I
S
A
P
-
A
G
E
-MK
T
I
VY
N
VN
D
D
T
L
D
G
N
D
T
IVS
V
ASCTTNCLAP
M
AK
A
L
H
D
S
FGIE
V
GTMTTIHA
Y
T
G
TQ
SL
VDGP
R
G
KDLR
AS
RAA
AE
NIIP
HT
TGAAKAIG
L
V
I
PEL
S
GKL
K
G
H
A
Q
RVP
V
K
TG
SV
T
E
L
V
S
I
L
G
K
K
VTAEEVN
N
ALK
Q
A
T
T
N
NES
-
-F
GYT
D
EE
I
VS
S
D
II
G
SHFG
SVFDATQ
T
EI
TAV
G
D
LQ
LVKTV
A
WYDNE
Y
GF
V
T
QL
IRTLEKFA
K
fig|595495.4.peg.932
Escherichia coli KO11 (3-332/333)
KVGINGFGRIGR
L
V
L
RRL
L
E
--
V
K
S
N
I
D
VVAINDL
T
SP
KI
L
AYLLK
H
DS
N
Y
G
P
F
P
W
S
V
DFTE
D
S
LIV
D
GK
S
I
A
V
Y
AE
K
EAK
N
I
PW
K
A
K
G
AEII
V
ECTG
F
Y
T
S
A
E
KS
Q
AH
L
D
AGAKKVL
I
S
A
P
-
A
G
E
-MK
T
I
VY
N
VN
D
D
T
L
D
G
N
D
T
IVS
V
ASCTTNCLAP
M
AK
A
L
H
D
S
FGIE
V
GTMTTIHA
Y
T
G
TQ
SL
VDGP
R
G
KDLR
AS
RAA
AE
NIIP
HT
TGAAKAIG
L
V
I
PEL
S
GKL
K
G
H
A
Q
RVP
V
K
TG
SV
T
E
L
V
S
I
L
G
K
K
VTAEEVN
N
ALK
Q
A
T
T
N
NES
-
-F
GYT
D
EE
I
VS
S
D
II
G
SHFG
SVFDATQ
T
EI
TAV
G
D
LQ
LVKTV
A
WYDNE
Y
GF
V
T
QL
IRTLEKFA
K
fig|679207.4.peg.4637
Escherichia coli MS 107-1 (3-332/333)
KVGINGFGRIGR
L
V
L
RRL
L
E
--
V
K
S
N
I
D
VVAINDL
T
SP
KI
L
AYLLK
H
DS
N
Y
G
P
F
P
W
S
V
DFTE
D
S
LIV
D
GK
S
I
A
V
Y
AE
K
EAK
N
I
PW
K
A
K
G
AEII
V
ECTG
F
Y
T
S
A
E
KS
Q
AH
L
D
AGAKKVL
I
S
A
P
-
A
G
E
-MK
T
I
VY
N
VN
D
D
T
L
D
G
N
D
T
IVS
V
ASCTTNCLAP
M
AK
A
L
H
D
S
FGIE
V
GTMTTIHA
Y
T
G
TQ
SL
VDGP
R
G
KDLR
AS
RAA
AE
NIIP
HT
TGAAKAIG
L
V
I
PEL
S
GKL
K
G
H
A
Q
RVP
V
K
TG
SV
T
E
L
V
S
I
L
G
K
K
VTAEEVN
N
ALK
Q
A
T
T
N
NES
-
-F
GYT
D
EE
I
VS
S
D
II
G
SHFG
SVFDATQ
T
EI
TAV
G
D
LQ
LVKTV
A
WYDNE
Y
GF
V
T
QL
IRTLEKFA
K
fig|749537.3.peg.131
Escherichia coli MS 115-1 (3-332/333)
KVGINGFGRIGR
L
V
L
RRL
L
E
--
V
K
S
N
I
D
VVAINDL
T
SP
KI
L
AYLLK
H
DS
N
Y
G
P
F
P
W
S
V
DFTE
D
S
LIV
D
GK
S
I
A
V
Y
AE
K
EAK
N
I
PW
K
A
K
G
AEII
V
ECTG
F
Y
T
S
A
E
KS
Q
AH
L
D
AGAKKVL
I
S
A
P
-
A
G
E
-MK
T
I
VY
N
VN
D
D
T
L
D
G
N
D
T
IVS
V
ASCTTNCLAP
M
AK
A
L
H
D
S
FGIE
V
GTMTTIHA
Y
T
G
TQ
SL
VDGP
R
G
KDLR
AS
RAA
AE
NIIP
HT
TGAAKAIG
L
V
I
PEL
S
GKL
K
G
H
A
Q
RVP
V
K
TG
SV
T
E
L
V
S
I
L
G
K
K
VTAEEVN
N
ALK
Q
A
T
T
N
NES
-
-F
GYT
D
EE
I
VS
S
D
II
G
SHFG
SVFDATQ
T
EI
TAV
G
D
LQ
LVKTV
A
WYDNE
Y
GF
V
T
QL
IRTLEKFA
K
fig|679206.4.peg.3041
Escherichia coli MS 119-7 (3-332/333)
KVGINGFGRIGR
L
V
L
RRL
L
E
--
V
K
S
N
I
D
VVAINDL
T
SP
KI
L
AYLLK
H
DS
N
Y
G
P
F
P
W
S
V
DFTE
D
S
LIV
D
GK
S
I
A
V
Y
AE
K
EAK
N
I
PW
K
A
K
G
AEII
V
ECTG
F
Y
T
S
A
E
KS
Q
AH
L
D
AGAKKVL
I
S
A
P
-
A
G
E
-MK
T
I
VY
N
VN
D
D
T
L
D
G
N
D
T
IVS
V
ASCTTNCLAP
M
AK
A
L
H
D
S
FGIE
V
GTMTTIHA
Y
T
G
TQ
SL
VDGP
R
G
KDLR
AS
RAA
AE
NIIP
HT
TGAAKAIG
L
V
I
PEL
S
GKL
K
G
H
A
Q
RVP
V
K
TG
SV
T
E
L
V
S
I
L
G
K
K
VTAEEVN
N
ALK
Q
A
T
T
N
NES
-
-F
GYT
D
EE
I
VS
S
D
II
G
SHFG
SVFDATQ
T
EI
TAV
G
D
LQ
LVKTV
A
WYDNE
Y
GF
V
T
QL
IRTLEKFA
K
fig|679205.4.peg.3404
Escherichia coli MS 124-1 (3-332/333)
KVGINGFGRIGR
L
V
L
RRL
L
E
--
V
K
S
N
I
D
VVAINDL
T
SP
KI
L
AYLLK
H
DS
N
Y
G
P
F
P
W
S
V
DFTE
D
S
LIV
D
GK
S
I
A
V
Y
AE
K
EAK
N
I
PW
K
A
K
G
AEII
V
ECTG
F
Y
T
S
A
E
KS
Q
AH
L
D
AGAKKVL
I
S
A
P
-
A
G
E
-MK
T
I
VY
N
VN
D
D
T
L
D
G
N
D
T
IVS
V
ASCTTNCLAP
M
AK
A
L
H
D
S
FGIE
V
GTMTTIHA
Y
T
G
TQ
SL
VDGP
R
G
KDLR
AS
RAA
AE
NIIP
HT
TGAAKAIG
L
V
I
PEL
S
GKL
K
G
H
A
Q
RVP
V
K
TG
SV
T
E
L
V
S
I
L
G
K
K
VTAEEVN
N
ALK
Q
A
T
T
N
NES
-
-F
GYT
D
EE
I
VS
S
D
II
G
SHFG
SVFDATQ
T
EI
TAV
G
D
LQ
LVKTV
A
WYDNE
Y
GF
V
T
QL
IRTLEKFA
K
fig|749547.3.peg.53
Escherichia coli MS 187-1 (3-332/333)
KVGINGFGRIGR
L
V
L
RRL
L
E
--
V
K
S
N
I
D
VVAINDL
T
SP
KI
L
AYLLK
H
DS
N
Y
G
P
F
P
W
S
V
DFTE
D
S
LIV
D
GK
S
I
A
V
Y
AE
K
EAK
N
I
PW
K
A
K
G
AEII
V
ECTG
F
Y
T
S
A
E
KS
Q
AH
L
D
AGAKKVL
I
S
A
P
-
A
G
E
-MK
T
I
VY
N
VN
D
D
T
L
D
G
N
D
T
IVS
V
ASCTTNCLAP
M
AK
A
L
H
D
S
FGIE
V
GTMTTIHA
Y
T
G
TQ
SL
VDGP
R
G
KDLR
AS
RAA
AE
NIIP
HT
TGAAKAIG
L
V
I
PEL
S
GKL
K
G
H
A
Q
RVP
V
K
TG
SV
T
E
L
V
S
I
L
G
K
K
VTAEEVN
N
ALK
Q
A
T
T
N
NES
-
-F
GYT
D
EE
I
VS
S
D
II
G
SHFG
SVFDATQ
T
EI
TAV
G
D
LQ
LVKTV
A
WYDNE
Y
GF
V
T
QL
IRTLEKFA
K
fig|749533.3.peg.42
Escherichia coli MS 84-1 (3-332/333)
KVGINGFGRIGR
L
V
L
RRL
L
E
--
V
K
S
N
I
D
VVAINDL
T
SP
KI
L
AYLLK
H
DS
N
Y
G
P
F
P
W
S
V
DFTE
D
S
LIV
D
GK
S
I
A
V
Y
AE
K
EAK
N
I
PW
K
A
K
G
AEII
V
ECTG
F
Y
T
S
A
E
KS
Q
AH
L
D
AGAKKVL
I
S
A
P
-
A
G
E
-MK
T
I
VY
N
VN
D
D
T
L
D
G
N
D
T
IVS
V
ASCTTNCLAP
M
AK
A
L
H
D
S
FGIE
V
GTMTTIHA
Y
T
G
TQ
SL
VDGP
R
G
KDLR
AS
RAA
AE
NIIP
HT
TGAAKAIG
L
V
I
PEL
S
GKL
K
G
H
A
Q
RVP
V
K
TG
SV
T
E
L
V
S
I
L
G
K
K
VTAEEVN
N
ALK
Q
A
T
T
N
NES
-
-F
GYT
D
EE
I
VS
S
D
II
G
SHFG
SVFDATQ
T
EI
TAV
G
D
LQ
LVKTV
A
WYDNE
Y
GF
V
T
QL
IRTLEKFA
K
fig|585395.4.peg.1624
Escherichia coli O103:H2 str. 12009 (3-332/333)
KVGINGFGRIGR
L
V
L
RRL
L
E
--
V
K
S
N
I
D
VVAINDL
T
SP
KI
L
AYLLK
H
DS
N
Y
G
P
F
P
W
S
V
DFTE
D
S
LIV
D
GK
S
I
A
V
Y
AE
K
EAK
N
I
PW
K
A
K
G
AEII
V
ECTG
F
Y
T
S
A
E
KS
Q
AH
L
D
AGAKKVL
I
S
A
P
-
A
G
E
-MK
T
I
VY
N
VN
D
D
T
L
D
G
N
D
T
IVS
V
ASCTTNCLAP
M
AK
A
L
H
D
S
FGIE
V
GTMTTIHA
Y
T
G
TQ
SL
VDGP
R
G
KDLR
AS
RAA
AE
NIIP
HT
TGAAKAIG
L
V
I
PEL
S
GKL
K
G
H
A
Q
RVP
V
K
TG
SV
T
E
L
V
S
I
L
G
K
K
VTAEEVN
N
ALK
Q
A
T
T
N
NES
-
-F
GYT
D
EE
I
VS
S
D
II
G
SHFG
SVFDATQ
T
EI
TAV
G
D
LQ
LVKTV
A
WYDNE
Y
GF
V
T
QL
IRTLEKFA
K
fig|566546.3.peg.49
Escherichia coli W (3-332/333)
KVGINGFGRIGR
L
V
L
RRL
L
E
--
V
K
S
N
I
D
VVAINDL
T
SP
KI
L
AYLLK
H
DS
N
Y
G
P
F
P
W
S
V
DFTE
D
S
LIV
D
GK
S
I
A
V
Y
AE
K
EAK
N
I
PW
K
A
K
G
AEII
V
ECTG
F
Y
T
S
A
E
KS
Q
AH
L
D
AGAKKVL
I
S
A
P
-
A
G
E
-MK
T
I
VY
N
VN
D
D
T
L
D
G
N
D
T
IVS
V
ASCTTNCLAP
M
AK
A
L
H
D
S
FGIE
V
GTMTTIHA
Y
T
G
TQ
SL
VDGP
R
G
KDLR
AS
RAA
AE
NIIP
HT
TGAAKAIG
L
V
I
PEL
S
GKL
K
G
H
A
Q
RVP
V
K
TG
SV
T
E
L
V
S
I
L
G
K
K
VTAEEVN
N
ALK
Q
A
T
T
N
NES
-
-F
GYT
D
EE
I
VS
S
D
II
G
SHFG
SVFDATQ
T
EI
TAV
G
D
LQ
LVKTV
A
WYDNE
Y
GF
V
T
QL
IRTLEKFA
K
fig|566546.4.peg.1532
Escherichia coli W (3-332/333)
KVGINGFGRIGR
L
V
L
RRL
L
E
--
V
K
S
N
I
D
VVAINDL
T
SP
KI
L
AYLLK
H
DS
N
Y
G
P
F
P
W
S
V
DFTE
D
S
LIV
D
GK
S
I
A
V
Y
AE
K
EAK
N
I
PW
K
A
K
G
AEII
V
ECTG
F
Y
T
S
A
E
KS
Q
AH
L
D
AGAKKVL
I
S
A
P
-
A
G
E
-MK
T
I
VY
N
VN
D
D
T
L
D
G
N
D
T
IVS
V
ASCTTNCLAP
M
AK
A
L
H
D
S
FGIE
V
GTMTTIHA
Y
T
G
TQ
SL
VDGP
R
G
KDLR
AS
RAA
AE
NIIP
HT
TGAAKAIG
L
V
I
PEL
S
GKL
K
G
H
A
Q
RVP
V
K
TG
SV
T
E
L
V
S
I
L
G
K
K
VTAEEVN
N
ALK
Q
A
T
T
N
NES
-
-F
GYT
D
EE
I
VS
S
D
II
G
SHFG
SVFDATQ
T
EI
TAV
G
D
LQ
LVKTV
A
WYDNE
Y
GF
V
T
QL
IRTLEKFA
K
fig|216592.1.peg.1952
Escherichia coli 042 (3-332/333)
KVGINGFGRIGR
L
V
L
RRL
L
E
--
V
K
S
N
I
D
I
VAINDL
T
SP
KI
L
AYLLK
H
DS
N
Y
G
P
F
P
W
R
V
DFTE
D
S
LIV
D
GK
S
I
A
V
Y
AE
K
EAK
N
I
PW
K
A
K
G
AEII
V
ECTG
F
Y
T
S
A
E
KS
Q
AH
L
D
AGAKKVL
I
S
A
P
-
A
G
E
-MK
T
I
VY
N
VN
D
D
T
L
D
G
N
D
T
IVS
V
ASCTTNCLAP
M
AK
A
L
H
D
S
FGIE
V
GTMTTIHA
Y
T
G
TQ
SL
VDGP
R
G
KDLR
AS
RAA
AE
NIIP
HT
TGAAKAIG
L
V
I
PEL
S
GKL
K
G
H
A
Q
RVP
V
K
TG
SV
T
E
L
V
S
I
L
G
K
K
VTAEEVN
N
ALK
K
A
T
N
N
NES
-
-F
GYT
D
EE
I
VS
S
D
II
G
SHFG
SVFDATQ
T
EI
TAV
G
D
LQ
LVKTV
A
WYDNE
Y
GF
V
T
QL
IRTLEKFA
K
fig|216592.3.peg.1606
Escherichia coli 042 (3-332/333)
KVGINGFGRIGR
L
V
L
RRL
L
E
--
V
K
S
N
I
D
I
VAINDL
T
SP
KI
L
AYLLK
H
DS
N
Y
G
P
F
P
W
R
V
DFTE
D
S
LIV
D
GK
S
I
A
V
Y
AE
K
EAK
N
I
PW
K
A
K
G
AEII
V
ECTG
F
Y
T
S
A
E
KS
Q
AH
L
D
AGAKKVL
I
S
A
P
-
A
G
E
-MK
T
I
VY
N
VN
D
D
T
L
D
G
N
D
T
IVS
V
ASCTTNCLAP
M
AK
A
L
H
D
S
FGIE
V
GTMTTIHA
Y
T
G
TQ
SL
VDGP
R
G
KDLR
AS
RAA
AE
NIIP
HT
TGAAKAIG
L
V
I
PEL
S
GKL
K
G
H
A
Q
RVP
V
K
TG
SV
T
E
L
V
S
I
L
G
K
K
VTAEEVN
N
ALK
K
A
T
N
N
NES
-
-F
GYT
D
EE
I
VS
S
D
II
G
SHFG
SVFDATQ
T
EI
TAV
G
D
LQ
LVKTV
A
WYDNE
Y
GF
V
T
QL
IRTLEKFA
K
fig|749538.3.peg.3480
Escherichia coli MS 116-1 (3-332/333)
KVGINGFGRIGR
L
V
L
G
RL
L
E
--
V
K
S
N
I
D
VVAINDL
T
SP
XI
L
AYLLK
H
DS
N
Y
G
P
F
P
W
S
V
DFTE
D
S
LIV
D
GK
S
I
A
V
Y
AE
K
EAK
N
I
PW
K
A
K
G
AEII
V
ECTG
F
Y
T
S
A
E
KS
Q
T
H
L
D
AGAKKVL
I
S
A
P
-
A
G
E
-MK
T
I
VY
N
VN
D
D
T
L
D
G
N
D
T
IVS
V
ASCTTNCLAP
M
AK
A
L
H
D
S
FGIE
V
GTMTTIHA
Y
T
G
TQ
SL
VDGP
R
G
KDLR
AS
RAA
AE
NIIP
HT
TGAAKAIG
L
V
I
PEL
S
GKL
K
G
H
A
Q
RVP
V
K
TG
SV
T
E
L
V
S
I
L
G
K
K
X
TAEEVN
N
ALK
Q
A
T
T
N
NES
-
-F
GYT
D
EE
I
VS
S
D
II
G
SHFG
SVFDATQ
T
EI
TAV
G
D
LQ
LVKTV
A
WYDNE
Y
GF
V
T
QL
IRTLEKFA
K
fig|656414.3.peg.1696
Escherichia coli H736 (3-332/333)
KVGINGFGRIGR
L
V
L
G
RL
L
E
--
V
K
S
N
I
D
VVAINDL
T
SP
XI
L
AYLLK
H
DS
N
Y
G
P
F
P
W
S
V
DFTE
D
S
LIV
D
GK
S
I
A
V
Y
AE
K
EAK
N
I
PW
K
A
K
G
AEII
V
ECTG
F
Y
T
S
A
E
KS
Q
AH
L
D
AGAKKVL
I
S
A
P
-
A
G
E
-MK
T
I
VY
N
VN
D
D
T
L
D
G
N
D
T
IVS
V
ASCTTNCLAP
M
AK
A
L
H
D
S
FGIE
V
GTMTTIHA
Y
T
G
TQ
SL
VDGP
R
G
KDLR
AS
RAA
AE
NIIP
HT
TGAAKAIG
L
V
I
PEL
S
GKL
K
G
H
A
Q
RVP
V
K
TG
SV
T
E
L
V
S
I
L
G
K
K
X
TAEEVN
N
ALK
Q
A
T
T
N
NES
-
-F
GYT
D
EE
I
VS
S
D
II
G
SHFG
SVFDATQ
T
EI
TAV
G
D
LQ
LVKTV
A
WYDNE
Y
GF
V
T
QL
IRTLEKFA
K
fig|749540.3.peg.3487
Escherichia coli MS 146-1 (3-332/333)
KVGINGFGRIGR
L
V
L
G
RL
L
E
--
V
K
S
N
I
D
VVAINDL
T
SP
XI
L
AYLLK
H
DS
N
Y
G
P
F
P
W
S
V
DFTE
D
S
LIV
D
GK
S
I
A
V
Y
AE
K
EAK
N
I
PW
K
A
K
G
AEII
V
ECTG
F
Y
T
S
A
E
KS
Q
AH
L
D
AGAKKVL
I
S
A
P
-
A
G
E
-MK
T
I
VY
N
VN
D
D
T
L
D
G
N
D
T
IVS
V
ASCTTNCLAP
M
AK
A
L
H
D
S
FGIE
V
GTMTTIHA
Y
T
G
TQ
SL
VDGP
R
G
KDLR
AS
RAA
AE
NIIP
HT
TGAAKAIG
L
V
I
PEL
S
GKL
K
G
H
A
Q
RVP
V
K
TG
SV
T
E
L
V
S
I
L
G
K
K
X
TAEEVN
N
ALK
Q
A
T
T
N
NES
-
-F
GYT
D
EE
I
VS
S
D
II
G
SHFG
SVFDATQ
T
EI
TAV
G
D
LQ
LVKTV
A
WYDNE
Y
GF
V
T
QL
IRTLEKFA
K
fig|749548.3.peg.50
Escherichia coli MS 196-1 (3-332/333)
KVGINGFGRIGR
L
V
L
G
RL
L
E
--
V
K
S
N
I
D
VVAINDL
T
SP
XI
L
AYLLK
H
DS
N
Y
G
P
F
P
W
S
V
DFTE
D
S
LIV
D
GK
S
I
A
V
Y
AE
K
EAK
N
I
PW
K
A
K
G
AEII
V
ECTG
F
Y
T
S
A
E
KS
Q
AH
L
D
AGAKKVL
I
S
A
P
-
A
G
E
-MK
T
I
VY
N
VN
D
D
T
L
D
G
N
D
T
IVS
V
ASCTTNCLAP
M
AK
A
L
H
D
S
FGIE
V
GTMTTIHA
Y
T
G
TQ
SL
VDGP
R
G
KDLR
AS
RAA
AE
NIIP
HT
TGAAKAIG
L
V
I
PEL
S
GKL
K
G
H
A
Q
RVP
V
K
TG
SV
T
E
L
V
S
I
L
G
K
K
X
TAEEVN
N
ALK
Q
A
T
T
N
NES
-
-F
GYT
D
EE
I
VS
S
D
II
G
SHFG
SVFDATQ
T
EI
TAV
G
D
LQ
LVKTV
A
WYDNE
Y
GF
V
T
QL
IRTLEKFA
K
fig|753642.3.peg.1745
Escherichia coli NC101 (3-332/333)
KVGINGFGRIGR
L
V
L
RRL
L
E
--
V
K
S
N
I
D
VVAINDL
T
SP
KI
L
AYLLK
H
DS
N
Y
G
P
F
P
W
S
I
DYTE
D
S
LIV
D
GK
S
I
A
V
Y
AE
K
EAK
N
I
PW
K
A
K
G
AEII
V
ECTG
F
Y
T
S
A
E
KS
Q
AH
L
D
AGAKKVL
I
S
A
P
-
A
G
E
-MK
T
I
VY
N
VN
D
D
T
L
D
G
N
D
T
IVS
V
ASCTTNCLAP
M
AK
A
L
H
D
S
FGIE
V
GTMTTIHA
Y
T
G
TQ
SL
VDGP
R
G
KDLR
AS
RAA
AE
NIIP
HT
TGAAKAIG
L
V
I
PEL
S
GKL
K
G
H
A
Q
RVP
V
K
TG
SV
T
E
L
V
S
I
L
G
K
K
VTAEEVN
N
ALK
K
A
T
N
N
NES
-
-F
GYT
D
EE
I
VS
S
D
II
G
SHFG
SVFDATQ
T
EI
TAV
G
D
LQ
LVKTV
A
WYDNE
Y
GF
V
T
QL
IRTLEKFA
K
fig|656440.3.peg.1283
Escherichia coli TA206 (3-332/333)
KVGINGFGRIGR
L
V
L
RRL
L
E
--
V
K
S
N
I
D
VVAINDL
T
SP
KI
L
AYLLK
H
DS
N
Y
G
P
F
P
W
S
I
DYTE
D
S
LIV
D
GK
S
I
A
V
Y
AE
K
EAK
N
I
PW
K
A
K
G
AEII
V
ECTG
F
Y
T
S
A
E
KS
Q
AH
L
D
AGAKKVL
I
S
A
P
-
A
G
E
-MK
T
I
VY
N
VN
D
D
T
L
D
G
N
D
T
IVS
V
ASCTTNCLAP
M
AK
A
L
H
D
S
FGIE
V
GTMTTIHA
Y
T
G
TQ
SL
VDGP
R
G
KDLR
AS
RAA
AE
NIIP
HT
TGAAKAIG
L
V
I
PEL
S
GKL
K
G
H
A
Q
RVP
V
K
TG
SV
T
E
L
V
S
I
L
G
K
K
VTAEEVN
N
ALK
K
A
T
N
N
NES
-
-F
GYT
D
EE
I
VS
S
D
II
G
SHFG
SVFDATQ
T
EI
TAV
G
D
LQ
LVKTV
A
WYDNE
Y
GF
V
T
QL
IRTLEKFA
K
fig|656417.3.peg.1684
Escherichia coli M605 (3-332/333)
KVGINGFGRIGR
L
V
L
RRL
L
E
--
V
K
S
N
I
D
VVAINDL
T
SP
KI
L
AYLLK
H
DS
N
Y
G
P
F
P
W
S
V
DYTE
D
S
LIV
D
GK
S
I
A
V
Y
AE
K
EAK
N
I
PW
K
A
K
G
AEII
V
ECTG
F
Y
T
S
A
E
KS
Q
AH
L
D
AGAKKVL
I
S
A
P
-
A
G
E
-MK
T
I
VY
N
VN
D
D
T
L
D
G
N
D
T
IVS
V
ASCTTNCLAP
M
AK
A
L
H
D
S
FGIE
V
GTMTTIHA
Y
T
G
TQ
SL
VDGP
R
G
KDLR
AS
RAA
AE
NIIP
HT
TGAAKAIG
L
V
I
PEL
S
GKL
K
G
H
A
Q
RVP
V
K
TG
SV
T
E
L
V
S
I
L
G
K
K
VTAEEVN
N
ALK
K
A
T
N
N
NES
-
-F
GYT
D
EE
I
VS
S
D
II
G
SHFG
SVFDATQ
T
EI
S
AV
G
D
LQ
LVKTV
A
WYDNE
Y
GF
V
T
QL
IRTLEKFA
K
fig|573235.3.peg.2048
Escherichia coli O26:H11 str. 11368 (3-332/333)
KVGINGFGRIGR
L
V
L
RRL
L
E
--
V
K
S
N
I
D
VVAINDL
T
SP
KI
L
AYLLK
H
DS
N
Y
G
P
F
L
W
S
V
DFTE
D
S
LIV
D
GK
S
I
A
V
Y
AE
K
EAK
N
I
PW
K
A
K
G
AEII
V
ECTG
F
Y
T
S
A
E
KS
Q
AH
L
D
AGAKKVL
I
S
A
P
-
A
G
E
-MK
T
I
VY
N
VN
D
D
T
L
D
G
N
D
T
IVS
V
ASCTTNCLAP
M
AK
A
L
H
D
S
FGIE
V
GTMTTIHA
Y
T
G
TQ
SL
VDGP
R
G
KDLR
AS
RAA
AE
NIIP
HT
TGAAKAIG
L
V
I
PEL
S
GKL
K
G
H
A
Q
RVP
V
K
TG
SV
T
E
L
V
S
I
L
G
K
K
VTAEEVN
N
ALK
Q
A
T
T
N
NES
-
-F
GYT
D
EE
I
VS
S
D
II
G
SHFG
SVFDATQ
T
EI
TAV
G
D
LQ
LVKTV
A
WYDNE
Y
GF
V
T
QL
IRTLEKFA
K
fig|656379.3.peg.3454
Escherichia coli FVEC1302 (3-332/333)
KVGINGFGRIGR
L
V
L
RRL
L
E
--
V
K
S
N
I
D
VVAINDL
T
SP
KI
L
AYLLK
H
DS
N
Y
G
P
F
P
W
R
V
DFTE
D
S
LIV
D
GK
S
I
A
V
Y
AE
K
EAK
N
I
PW
K
A
K
G
AEII
V
ECTG
F
Y
T
S
A
E
KS
Q
AH
L
D
AGAKKVL
I
S
A
P
-
A
G
E
-MK
T
I
VY
N
VN
D
D
T
L
D
G
N
D
T
IVS
V
ASCTTNCLAP
M
AK
A
L
H
D
S
FGIE
V
GTMTTIHA
Y
T
G
TQ
SL
VDGP
R
G
KDLR
AS
RAA
AE
NIIP
HT
TGAAKAIG
L
V
I
PEL
S
GKL
K
G
H
A
Q
RVP
V
K
TG
SV
T
E
L
V
S
I
L
G
K
K
VTAEEVN
N
ALK
N
A
T
N
N
NES
-
-F
GYT
D
EE
I
VS
S
D
II
G
SHFG
SVFDATQ
T
EI
TAV
G
D
LQ
LVKTV
A
WYDNE
Y
GF
V
T
QL
IRTLEKFA
K
fig|656380.3.peg.2808
Escherichia coli FVEC1412 (3-332/333)
KVGINGFGRIGR
L
V
L
RRL
L
E
--
V
K
S
N
I
D
VVAINDL
T
SP
KI
L
AYLLK
H
DS
N
Y
G
P
F
P
W
R
V
DFTE
D
S
LIV
D
GK
S
I
A
V
Y
AE
K
EAK
N
I
PW
K
A
K
G
AEII
V
ECTG
F
Y
T
S
A
E
KS
Q
AH
L
D
AGAKKVL
I
S
A
P
-
A
G
E
-MK
T
I
VY
N
VN
D
D
T
L
D
G
N
D
T
IVS
V
ASCTTNCLAP
M
AK
A
L
H
D
S
FGIE
V
GTMTTIHA
Y
T
G
TQ
SL
VDGP
R
G
KDLR
AS
RAA
AE
NIIP
HT
TGAAKAIG
L
V
I
PEL
S
GKL
K
G
H
A
Q
RVP
V
K
TG
SV
T
E
L
V
S
I
L
G
K
K
VTAEEVN
N
ALK
N
A
T
N
N
NES
-
-F
GYT
D
EE
I
VS
S
D
II
G
SHFG
SVFDATQ
T
EI
TAV
G
D
LQ
LVKTV
A
WYDNE
Y
GF
V
T
QL
IRTLEKFA
K
fig|749549.3.peg.3905
Escherichia coli MS 198-1 (3-332/333)
KVGINGFGRIGR
L
V
L
RRL
L
E
--
V
K
S
N
I
D
VVAINDL
T
SP
KI
L
AYLLK
H
DS
N
Y
G
P
F
P
W
R
V
DFTE
D
S
LIV
D
GK
S
I
A
V
Y
AE
K
EAK
N
I
PW
K
A
K
G
AEII
V
ECTG
F
Y
T
S
A
E
KS
Q
AH
L
D
AGAKKVL
I
S
A
P
-
A
G
E
-MK
T
I
VY
N
VN
D
D
T
L
D
G
N
D
T
IVS
V
ASCTTNCLAP
M
AK
A
L
H
D
S
FGIE
V
GTMTTIHA
Y
T
G
TQ
SL
VDGP
R
G
KDLR
AS
RAA
AE
NIIP
HT
TGAAKAIG
L
V
I
PEL
S
GKL
K
G
H
A
Q
RVP
V
K
TG
SV
T
E
L
V
S
I
L
G
K
K
VTAEEVN
N
ALK
N
A
T
N
N
NES
-
-F
GYT
D
EE
I
VS
S
D
II
G
SHFG
SVFDATQ
T
EI
TAV
G
D
LQ
LVKTV
A
WYDNE
Y
GF
V
T
QL
IRTLEKFA
K
fig|585056.7.peg.1858
Escherichia coli UMN026 (3-332/333)
KVGINGFGRIGR
L
V
L
RRL
L
E
--
V
K
S
N
I
D
VVAINDL
T
SP
KI
L
AYLLK
H
DS
N
Y
G
P
F
P
W
R
V
DFTE
D
S
LIV
D
GK
S
I
A
V
Y
AE
K
EAK
N
I
PW
K
A
K
G
AEII
V
ECTG
F
Y
T
S
A
E
KS
Q
AH
L
D
AGAKKVL
I
S
A
P
-
A
G
E
-MK
T
I
VY
N
VN
D
D
T
L
D
G
N
D
T
IVS
V
ASCTTNCLAP
M
AK
A
L
H
D
S
FGIE
V
GTMTTIHA
Y
T
G
TQ
SL
VDGP
R
G
KDLR
AS
RAA
AE
NIIP
HT
TGAAKAIG
L
V
I
PEL
S
GKL
K
G
H
A
Q
RVP
V
K
TG
SV
T
E
L
V
S
I
L
G
K
K
VTAEEVN
N
ALK
N
A
T
N
N
NES
-
-F
GYT
D
EE
I
VS
S
D
II
G
SHFG
SVFDATQ
T
EI
TAV
G
D
LQ
LVKTV
A
WYDNE
Y
GF
V
T
QL
IRTLEKFA
K
fig|550672.3.peg.912
Escherichia coli B088 (3-332/333)
KVGINGFGRIGR
L
V
L
RRL
L
E
--
V
K
S
N
I
D
VVAINDL
T
SP
KI
L
AYLLK
H
DS
N
Y
G
P
F
P
W
S
V
DFTE
D
S
LIV
D
GK
S
I
A
V
Y
AE
K
EAK
N
I
PW
K
A
K
G
AEII
V
ECTG
F
Y
T
S
A
E
KS
Q
AH
L
D
AGAKKVL
I
S
A
P
-
A
G
E
-MK
T
I
VY
N
VN
D
D
T
L
D
G
N
D
T
IVS
V
ASCTTNCLAP
M
AK
A
L
H
D
S
FGIE
V
GTMTTIHA
Y
T
G
TQ
SL
VDGP
R
G
KDLR
AS
RAA
AE
NIIP
HT
TGAAKAIG
L
V
I
PEL
S
GKL
K
G
H
A
Q
RVP
V
K
TG
SV
T
E
L
V
S
I
L
G
K
K
VTAEEVN
N
ALK
Q
A
T
T
N
NES
-
-F
GY
S
D
EE
I
VS
S
D
II
G
SHFG
SVFDATQ
T
EI
TAV
G
D
LQ
LVKTV
A
WYDNE
Y
GF
V
T
QL
IRTLEKFA
K
fig|585034.4.peg.1401
Escherichia coli IAI1 (3-332/333)
KVGINGFGRIGR
L
V
L
RRL
L
E
--
V
K
S
N
I
D
VVAINDL
T
SP
KI
L
AYLLK
H
DS
N
Y
G
P
F
P
W
S
V
DFTE
D
S
LIV
D
GK
S
I
A
V
Y
AE
K
EAK
N
I
PW
K
A
K
G
AEII
V
ECTG
F
Y
T
S
A
E
KS
Q
AH
L
D
AGAKKVL
I
S
A
P
-
A
G
E
-MK
T
I
VY
N
VN
D
D
T
L
D
G
N
D
T
IVS
V
ASCTTNCLAP
M
AK
A
L
H
D
S
FGIE
V
GTMTTIHA
Y
T
G
TQ
SL
VDGP
R
G
KDLR
AS
RAA
AE
NIIP
HT
TGAAKAIG
L
V
I
PEL
S
GKL
K
G
H
A
Q
RVP
V
K
TG
SV
T
E
L
V
S
I
L
G
K
K
VTAEEVN
N
ALK
Q
A
T
T
N
NES
-
-F
GY
S
D
EE
I
VS
S
D
II
G
SHFG
SVFDATQ
T
EI
TAV
G
D
LQ
LVKTV
A
WYDNE
Y
GF
V
T
QL
IRTLEKFA
K
fig|585034.5.peg.1397
Escherichia coli IAI1 (3-332/333)
KVGINGFGRIGR
L
V
L
RRL
L
E
--
V
K
S
N
I
D
VVAINDL
T
SP
KI
L
AYLLK
H
DS
N
Y
G
P
F
P
W
S
V
DFTE
D
S
LIV
D
GK
S
I
A
V
Y
AE
K
EAK
N
I
PW
K
A
K
G
AEII
V
ECTG
F
Y
T
S
A
E
KS
Q
AH
L
D
AGAKKVL
I
S
A
P
-
A
G
E
-MK
T
I
VY
N
VN
D
D
T
L
D
G
N
D
T
IVS
V
ASCTTNCLAP
M
AK
A
L
H
D
S
FGIE
V
GTMTTIHA
Y
T
G
TQ
SL
VDGP
R
G
KDLR
AS
RAA
AE
NIIP
HT
TGAAKAIG
L
V
I
PEL
S
GKL
K
G
H
A
Q
RVP
V
K
TG
SV
T
E
L
V
S
I
L
G
K
K
VTAEEVN
N
ALK
Q
A
T
T
N
NES
-
-F
GY
S
D
EE
I
VS
S
D
II
G
SHFG
SVFDATQ
T
EI
TAV
G
D
LQ
LVKTV
A
WYDNE
Y
GF
V
T
QL
IRTLEKFA
K
fig|656444.3.peg.2197
Escherichia coli TA280 (3-332/333)
KVGINGFGRIGR
L
V
L
RRL
L
E
--
V
K
S
N
I
D
VVAINDL
T
SP
KI
L
AYLLK
H
DS
N
Y
G
P
F
P
W
S
V
DFTE
D
S
LIV
D
GK
S
I
A
V
Y
AE
K
EAK
N
I
PW
K
A
K
G
AEII
V
ECTG
F
Y
T
S
A
E
KS
Q
AH
L
D
AGAKKVL
I
S
A
P
-
A
G
E
-MK
T
I
VY
N
VN
D
D
T
L
D
G
N
D
T
IVS
V
ASCTTNCLAP
M
AK
A
L
H
D
S
FGIE
V
GTMTTIHA
Y
T
G
TQ
SL
VDGP
R
G
KDLR
AS
RAA
AE
NIIP
HT
TGAAKAIG
L
V
I
PEL
S
GKL
K
G
H
A
Q
RVP
V
K
TG
SV
T
E
L
V
S
I
L
G
K
K
VTAEEVN
N
ALK
K
A
T
N
N
NES
-
-F
GYT
D
EE
I
VS
S
D
II
G
SHFG
SVFDATQ
T
EI
T
T
V
G
D
LQ
LVKTV
A
WYDNE
Y
GF
V
T
QL
IRTLEKFA
K
fig|585396.4.peg.1879
Escherichia coli O111:H- str. 11128 (3-332/333)
KVGINGFGRIGR
L
V
L
RRL
L
E
--
V
K
S
N
I
D
VVAINDL
T
SP
KI
L
AYLLK
H
DS
N
Y
G
P
F
P
W
S
V
DFTE
D
S
LIV
D
GK
S
I
A
V
Y
AE
K
EAK
N
I
PW
K
A
K
G
AEII
V
ECTG
F
Y
T
S
A
E
KS
Q
AH
L
D
AGAKKVL
I
S
A
P
-
A
G
E
-MK
T
I
VY
N
VN
D
D
T
L
D
G
N
D
T
IVS
V
ASCTTNCLAP
M
AK
A
L
H
D
S
FGIE
V
GTMTTIHA
Y
T
G
TQ
SL
VDGP
R
G
KDLR
AS
RAA
AE
NIIP
HT
TGAAKAIG
L
V
I
PEL
S
GKL
K
G
H
A
Q
RVP
V
K
TG
SV
T
E
L
V
S
I
L
G
K
K
VTAEEVN
N
ALK
Q
V
T
T
N
NES
-
-F
GYT
D
EE
I
VS
S
D
II
G
SHFG
SVFDATQ
T
EI
TAV
G
D
LQ
LVKTV
A
WYDNE
Y
GF
V
T
QL
IRTLEKFA
K
fig|585397.7.peg.1585
Escherichia coli ED1a (3-332/333)
KVGINGFGRIGR
L
V
L
RRL
L
E
--
V
K
S
N
I
D
VVAINDL
T
SP
KI
L
AYLLK
H
DS
N
Y
G
P
F
P
W
S
V
DYTE
D
S
LIV
D
GK
S
I
A
V
Y
AE
K
EAK
N
I
L
W
K
A
K
G
AEII
V
ECTG
F
Y
T
S
A
E
KS
Q
AH
L
D
AGAKKVL
I
S
A
P
-
A
G
E
-MK
T
I
VY
N
VN
D
D
T
L
D
G
N
D
T
IVS
V
ASCTTNCLAP
M
T
K
A
L
H
D
S
FGIE
V
GTMTTIHA
Y
T
G
TQ
SL
VDGP
R
G
KDLR
AS
RAA
AE
NIIP
HT
TGAAKAIG
L
V
I
PEL
S
GKL
K
G
H
A
Q
RVP
V
K
TG
SV
T
E
L
V
S
I
L
G
K
K
VTAEEVN
N
ALK
K
A
T
N
N
NES
-
-F
GYT
D
EE
I
VS
S
D
II
G
SHFG
SVFDATQ
T
EI
TAV
G
D
LQ
LVKTV
A
WYDNE
Y
GF
V
T
QL
IRTLEKFA
K
fig|585397.9.peg.1578
Escherichia coli ED1a (3-332/333)
KVGINGFGRIGR
L
V
L
RRL
L
E
--
V
K
S
N
I
D
VVAINDL
T
SP
KI
L
AYLLK
H
DS
N
Y
G
P
F
P
W
S
V
DYTE
D
S
LIV
D
GK
S
I
A
V
Y
AE
K
EAK
N
I
L
W
K
A
K
G
AEII
V
ECTG
F
Y
T
S
A
E
KS
Q
AH
L
D
AGAKKVL
I
S
A
P
-
A
G
E
-MK
T
I
VY
N
VN
D
D
T
L
D
G
N
D
T
IVS
V
ASCTTNCLAP
M
T
K
A
L
H
D
S
FGIE
V
GTMTTIHA
Y
T
G
TQ
SL
VDGP
R
G
KDLR
AS
RAA
AE
NIIP
HT
TGAAKAIG
L
V
I
PEL
S
GKL
K
G
H
A
Q
RVP
V
K
TG
SV
T
E
L
V
S
I
L
G
K
K
VTAEEVN
N
ALK
K
A
T
N
N
NES
-
-F
GYT
D
EE
I
VS
S
D
II
G
SHFG
SVFDATQ
T
EI
TAV
G
D
LQ
LVKTV
A
WYDNE
Y
GF
V
T
QL
IRTLEKFA
K
fig|340186.3.peg.229
Escherichia coli E110019 (3-332/333)
KVGINGFGRIGR
L
V
L
RRL
L
E
--
V
K
S
N
I
D
VVAINDL
T
SP
KI
L
AYLLK
H
DS
N
Y
G
P
F
P
W
S
V
DFTE
D
S
LIV
D
GK
S
I
A
V
Y
AE
K
EAK
N
I
PW
K
A
K
G
AEII
V
ECTG
F
Y
T
S
A
E
KS
Q
AH
L
D
AGAKKVL
I
S
A
P
-
A
G
E
-MK
T
I
VY
N
VN
D
D
T
L
D
G
N
D
T
IVS
V
ASCTTNCLAP
M
AK
A
L
H
D
S
FGIE
V
GTMTTIHA
Y
T
G
TQ
SL
VDGP
R
G
KDLR
AS
RAA
AE
NIIP
HT
TGAAKAIG
L
V
I
PEL
SD
KL
K
G
H
A
Q
RVP
V
K
TG
SV
T
E
L
V
S
I
L
G
K
K
VTAEEVN
N
ALK
Q
A
T
T
N
NES
-
-F
GYT
D
EE
I
VS
S
D
II
G
SHFG
SVFDATQ
T
EI
TAV
G
D
LQ
LVKTV
A
WYDNE
Y
GF
V
T
QL
IRTLEKFA
K
fig|340186.5.peg.245
Escherichia coli E110019 (3-332/333)
KVGINGFGRIGR
L
V
L
RRL
L
E
--
V
K
S
N
I
D
VVAINDL
T
SP
KI
L
AYLLK
H
DS
N
Y
G
P
F
P
W
S
V
DFTE
D
S
LIV
D
GK
S
I
A
V
Y
AE
K
EAK
N
I
PW
K
A
K
G
AEII
V
ECTG
F
Y
T
S
A
E
KS
Q
AH
L
D
AGAKKVL
I
S
A
P
-
A
G
E
-MK
T
I
VY
N
VN
D
D
T
L
D
G
N
D
T
IVS
V
ASCTTNCLAP
M
AK
A
L
H
D
S
FGIE
V
GTMTTIHA
Y
T
G
TQ
SL
VDGP
R
G
KDLR
AS
RAA
AE
NIIP
HT
TGAAKAIG
L
V
I
PEL
SD
KL
K
G
H
A
Q
RVP
V
K
TG
SV
T
E
L
V
S
I
L
G
K
K
VTAEEVN
N
ALK
Q
A
T
T
N
NES
-
-F
GYT
D
EE
I
VS
S
D
II
G
SHFG
SVFDATQ
T
EI
TAV
G
D
LQ
LVKTV
A
WYDNE
Y
GF
V
T
QL
IRTLEKFA
K
fig|409438.11.peg.1642
Escherichia coli SE11 (3-332/333)
KVGINGFGRIGR
L
V
L
RRL
L
E
--
V
K
S
N
I
D
VVAINDL
T
SP
KI
L
AYLLK
H
DS
N
Y
G
P
F
P
W
S
V
DFTE
D
S
LIV
D
GK
S
I
A
V
Y
AE
K
EAK
N
I
PW
K
A
K
G
AEII
V
ECTG
F
Y
T
S
A
E
KS
Q
AH
L
D
AGAKKVL
I
S
A
P
-
A
G
E
-MK
T
I
VY
N
VN
D
D
T
L
D
G
N
D
T
IVS
V
ASCTTNCLAP
M
AK
A
L
H
D
S
FGIE
V
GTMTTIHA
Y
T
G
TQ
SL
VDGP
R
G
KDLR
AS
RAA
AE
NIIP
HT
TGAAKAIG
L
V
I
P
K
L
S
GKL
K
G
H
A
Q
RVP
V
K
TG
SV
T
E
L
V
S
I
L
G
K
K
VTAEEVN
N
ALK
Q
A
T
T
N
NES
-
-F
GY
S
D
EE
I
VS
S
D
II
G
SHFG
SVFDATQ
T
EI
TAV
G
D
LQ
LVKTV
A
WYDNE
Y
GF
V
T
QL
IRTLEKFA
K
fig|749540.3.peg.386
Escherichia coli MS 146-1 (1-328/339)
MTV
R
V
A
INGFGRIGR
N
V
V
R
A
L
Y
E
SG
R
R
A
EI
T
VVAIN
E
L
A
DA
AG
MA
H
LLKYD
T
SHGRF
A
W
E
V
RQER
D
Q
L
F
V
G
DD
A
IRV
L
H
ER
SLQ
S
LPW
R
E
L
GVDVV
L
D
CTG
V
Y
G
S
R
E
HG
EAHI
A
AGAKKVL
F
S
H
P
G
S
N
D
LDA
T
V
VYG
A
N
Q
D
Q
L
R
A
E
H
R
IVSNASCTTNC
II
PV
I
K
L
LDDA
Y
GIE
S
GT
V
TTIH
S
A
M
H
D
Q
QV
I
D
A
-
Y
H
P
DLR
RT
RAASQ
S
IIP
VD
T
KL
A
AG
I
T
R
F
F
P
QF
N
DRF
E
A
I
A
V
RVPT
I
NV
TA
I
DL
S
V
T
V
K
K
P
V
K
A
N
EVN
L
L
L
Q
K
AA
Q
G
AFH
G
IV
D
YTE
LP
LVS
V
DFN
H
DPHS
AIV
D
G
TQ
-
--
T
R
V
S
G
AH
L
I
KT
L
V
W
C
DNE
W
GF
A
NRMLD
fig|637912.3.peg.3575
Escherichia coli OP50 (1-328/339)
MTV
R
V
A
INGFGRIGR
N
V
V
R
A
L
Y
E
SG
R
R
A
EI
T
VVAIN
E
L
A
DA
AG
MA
H
LLKYD
T
SHGRF
A
W
E
V
RQER
D
Q
L
F
V
G
DD
A
IRV
L
H
ER
SLQ
S
LPW
R
E
L
GVDVV
L
D
CTG
V
Y
G
S
R
E
HG
EAHI
A
AGAKKVL
F
S
H
P
G
S
N
D
LDA
T
V
VYGVN
Q
D
Q
L
R
A
E
H
R
IVSNASCTTNC
II
PV
I
K
L
LDDA
Y
GIE
S
GT
V
TTIH
S
A
M
H
D
Q
QV
I
D
A
-
Y
H
P
DLR
RT
RAASQ
S
IIP
VD
T
KL
A
AG
I
T
R
F
F
P
QF
N
DRF
E
A
I
A
V
RVPT
I
NV
TA
I
DL
S
V
T
V
K
K
P
V
K
A
N
EVN
L
L
L
Q
K
AA
Q
G
AFH
G
IV
D
YTE
LS
LVS
V
DFN
H
DPHS
AIV
D
G
TQ
-
--
T
R
V
S
G
AH
L
I
KT
L
V
W
C
DNE
W
GF
A
NRMLD
fig|1040638.4.peg.2452
Escherichia coli O104:H4 str. LB226692 (1-328/339)
MTV
R
V
A
INGFGRIGR
N
V
V
R
A
L
Y
E
SG
R
R
A
EI
T
VVAIN
E
L
A
DA
AG
MA
H
LLKYD
T
SHGRF
A
W
E
V
RQER
D
Q
L
F
V
G
DD
A
IRV
L
H
ER
SLQ
S
LPW
R
E
L
GVDVV
L
D
CTG
V
Y
G
S
R
E
HG
EAHI
A
AGAKKVL
F
S
H
P
G
S
N
D
LDA
T
V
VYGVN
Q
D
Q
L
R
A
E
H
R
IVSNASCTTNC
II
PV
I
K
L
LDDA
Y
GIE
S
GT
V
TTIH
S
A
M
H
D
Q
QV
I
D
A
-
Y
H
P
DLR
RT
RAASQ
S
IIP
VD
T
KL
A
AG
I
T
R
F
F
P
QF
N
DRF
E
A
I
A
V
RVPT
I
NV
TA
I
DL
S
V
T
V
K
K
P
V
K
A
N
EVN
L
L
L
Q
K
AA
Q
G
AFH
G
IV
D
YTE
LP
LVS
V
DFN
H
DPHS
AIV
D
G
TQ
-
--
T
R
V
S
G
AH
L
I
KT
L
V
W
C
DNE
W
GF
A
NRMLD
fig|6666666.5357.peg.3008
Escherichia coli TY-2482 (1-328/339)
MTV
R
V
A
INGFGRIGR
N
V
V
R
A
L
Y
E
SG
R
R
A
EI
T
VVAIN
E
L
A
DA
AG
MA
H
LLKYD
T
SHGRF
A
W
E
V
RQER
D
Q
L
F
V
G
DD
A
IRV
L
H
ER
SLQ
S
LPW
R
E
L
GVDVV
L
D
CTG
V
Y
G
S
R
E
HG
EAHI
A
AGAKKVL
F
S
H
P
G
S
N
D
LDA
T
V
VYGVN
Q
D
Q
L
R
A
E
H
R
IVSNASCTTNC
II
PV
I
K
L
LDDA
Y
GIE
S
GT
V
TTIH
S
A
M
H
D
Q
QV
I
D
A
-
Y
H
P
DLR
RT
RAASQ
S
IIP
VD
T
KL
A
AG
I
T
R
F
F
P
QF
N
DRF
E
A
I
A
V
RVPT
I
NV
TA
I
DL
S
V
T
V
K
K
P
V
K
A
N
EVN
L
L
L
Q
K
AA
Q
G
AFH
G
IV
D
YTE
LP
LVS
V
DFN
H
DPHS
AIV
D
G
TQ
-
--
T
R
V
S
G
AH
L
I
KT
L
V
W
C
DNE
W
GF
A
NRMLD
fig|216592.1.peg.3733
Escherichia coli 042 (29-356/367)
MTV
R
V
A
INGFGRIGR
N
V
V
R
A
L
Y
E
SG
R
R
A
EI
T
VVAIN
E
L
A
DA
AG
MA
H
LLKYD
T
SHGRF
A
W
E
V
RQER
D
Q
L
F
V
G
DD
A
IRV
L
H
ER
SLQ
S
LPW
R
E
L
GVDVV
L
D
CTG
V
Y
G
S
R
E
HG
EAHI
A
AGAKKVL
F
S
H
P
G
S
N
D
LDA
T
V
VYGVN
Q
D
Q
L
R
A
E
H
R
IVSNASCTTNC
II
PV
I
K
L
LDDA
Y
GIE
S
GT
V
TTIH
S
A
M
H
D
Q
QV
I
D
A
-
Y
H
P
DLR
RT
RAASQ
S
IIP
VD
T
KL
A
AG
I
T
R
F
F
P
QF
N
DRF
E
A
I
A
V
RVPT
I
NV
TA
I
DL
S
V
T
V
K
K
P
V
K
A
N
EVN
L
L
L
Q
K
AA
Q
G
AFH
G
IV
D
YTE
LP
LVS
V
DFN
H
DPHS
AIV
D
G
TQ
-
--
T
R
V
S
G
AH
L
I
KT
L
V
W
C
DNE
W
GF
A
NRMLD
fig|216592.3.peg.3269
Escherichia coli 042 (1-328/339)
MTV
R
V
A
INGFGRIGR
N
V
V
R
A
L
Y
E
SG
R
R
A
EI
T
VVAIN
E
L
A
DA
AG
MA
H
LLKYD
T
SHGRF
A
W
E
V
RQER
D
Q
L
F
V
G
DD
A
IRV
L
H
ER
SLQ
S
LPW
R
E
L
GVDVV
L
D
CTG
V
Y
G
S
R
E
HG
EAHI
A
AGAKKVL
F
S
H
P
G
S
N
D
LDA
T
V
VYGVN
Q
D
Q
L
R
A
E
H
R
IVSNASCTTNC
II
PV
I
K
L
LDDA
Y
GIE
S
GT
V
TTIH
S
A
M
H
D
Q
QV
I
D
A
-
Y
H
P
DLR
RT
RAASQ
S
IIP
VD
T
KL
A
AG
I
T
R
F
F
P
QF
N
DRF
E
A
I
A
V
RVPT
I
NV
TA
I
DL
S
V
T
V
K
K
P
V
K
A
N
EVN
L
L
L
Q
K
AA
Q
G
AFH
G
IV
D
YTE
LP
LVS
V
DFN
H
DPHS
AIV
D
G
TQ
-
--
T
R
V
S
G
AH
L
I
KT
L
V
W
C
DNE
W
GF
A
NRMLD
fig|562.371.peg.5663
Escherichia coli 1044A (1-328/339)
MTV
R
V
A
INGFGRIGR
N
V
V
R
A
L
Y
E
SG
R
R
A
EI
T
VVAIN
E
L
A
DA
AG
MA
H
LLKYD
T
SHGRF
A
W
E
V
RQER
D
Q
L
F
V
G
DD
A
IRV
L
H
ER
SLQ
S
LPW
R
E
L
GVDVV
L
D
CTG
V
Y
G
S
R
E
HG
EAHI
A
AGAKKVL
F
S
H
P
G
S
N
D
LDA
T
V
VYGVN
Q
D
Q
L
R
A
E
H
R
IVSNASCTTNC
II
PV
I
K
L
LDDA
Y
GIE
S
GT
V
TTIH
S
A
M
H
D
Q
QV
I
D
A
-
Y
H
P
DLR
RT
RAASQ
S
IIP
VD
T
KL
A
AG
I
T
R
F
F
P
QF
N
DRF
E
A
I
A
V
RVPT
I
NV
TA
I
DL
S
V
T
V
K
K
P
V
K
A
N
EVN
L
L
L
Q
K
AA
Q
G
AFH
G
IV
D
YTE
LP
LVS
V
DFN
H
DPHS
AIV
D
G
TQ
-
--
T
R
V
S
G
AH
L
I
KT
L
V
W
C
DNE
W
GF
A
NRMLD
fig|562.373.peg.4469
Escherichia coli 1125A (1-328/339)
MTV
R
V
A
INGFGRIGR
N
V
V
R
A
L
Y
E
SG
R
R
A
EI
T
VVAIN
E
L
A
DA
AG
MA
H
LLKYD
T
SHGRF
A
W
E
V
RQER
D
Q
L
F
V
G
DD
A
IRV
L
H
ER
SLQ
S
LPW
R
E
L
GVDVV
L
D
CTG
V
Y
G
S
R
E
HG
EAHI
A
AGAKKVL
F
S
H
P
G
S
N
D
LDA
T
V
VYGVN
Q
D
Q
L
R
A
E
H
R
IVSNASCTTNC
II
PV
I
K
L
LDDA
Y
GIE
S
GT
V
TTIH
S
A
M
H
D
Q
QV
I
D
A
-
Y
H
P
DLR
RT
RAASQ
S
IIP
VD
T
KL
A
AG
I
T
R
F
F
P
QF
N
DRF
E
A
I
A
V
RVPT
I
NV
TA
I
DL
S
V
T
V
K
K
P
V
K
A
N
EVN
L
L
L
Q
K
AA
Q
G
AFH
G
IV
D
YTE
LP
LVS
V
DFN
H
DPHS
AIV
D
G
TQ
-
--
T
R
V
S
G
AH
L
I
KT
L
V
W
C
DNE
W
GF
A
NRMLD
fig|562.372.peg.2396
Escherichia coli 1212A (1-328/339)
MTV
R
V
A
INGFGRIGR
N
V
V
R
A
L
Y
E
SG
R
R
A
EI
T
VVAIN
E
L
A
DA
AG
MA
H
LLKYD
T
SHGRF
A
W
E
V
RQER
D
Q
L
F
V
G
DD
A
IRV
L
H
ER
SLQ
S
LPW
R
E
L
GVDVV
L
D
CTG
V
Y
G
S
R
E
HG
EAHI
A
AGAKKVL
F
S
H
P
G
S
N
D
LDA
T
V
VYGVN
Q
D
Q
L
R
A
E
H
R
IVSNASCTTNC
II
PV
I
K
L
LDDA
Y
GIE
S
GT
V
TTIH
S
A
M
H
D
Q
QV
I
D
A
-
Y
H
P
DLR
RT
RAASQ
S
IIP
VD
T
KL
A
AG
I
T
R
F
F
P
QF
N
DRF
E
A
I
A
V
RVPT
I
NV
TA
I
DL
S
V
T
V
K
K
P
V
K
A
N
EVN
L
L
L
Q
K
AA
Q
G
AFH
G
IV
D
YTE
LP
LVS
V
DFN
H
DPHS
AIV
D
G
TQ
-
--
T
R
V
S
G
AH
L
I
KT
L
V
W
C
DNE
W
GF
A
NRMLD
fig|670888.3.peg.3355
Escherichia coli 1827-70 (1-328/339)
MTV
R
V
A
INGFGRIGR
N
V
V
R
A
L
Y
E
SG
R
R
A
EI
T
VVAIN
E
L
A
DA
AG
MA
H
LLKYD
T
SHGRF
A
W
E
V
RQER
D
Q
L
F
V
G
DD
A
IRV
L
H
ER
SLQ
S
LPW
R
E
L
GVDVV
L
D
CTG
V
Y
G
S
R
E
HG
EAHI
A
AGAKKVL
F
S
H
P
G
S
N
D
LDA
T
V
VYGVN
Q
D
Q
L
R
A
E
H
R
IVSNASCTTNC
II
PV
I
K
L
LDDA
Y
GIE
S
GT
V
TTIH
S
A
M
H
D
Q
QV
I
D
A
-
Y
H
P
DLR
RT
RAASQ
S
IIP
VD
T
KL
A
AG
I
T
R
F
F
P
QF
N
DRF
E
A
I
A
V
RVPT
I
NV
TA
I
DL
S
V
T
V
K
K
P
V
K
A
N
EVN
L
L
L
Q
K
AA
Q
G
AFH
G
IV
D
YTE
LP
LVS
V
DFN
H
DPHS
AIV
D
G
TQ
-
--
T
R
V
S
G
AH
L
I
KT
L
V
W
C
DNE
W
GF
A
NRMLD
fig|362663.8.peg.2947
Escherichia coli 536 (1-328/339)
MTV
R
V
A
INGFGRIGR
N
V
V
R
A
L
Y
E
SG
R
R
A
EI
T
VVAIN
E
L
A
DA
AG
MA
H
LLKYD
T
SHGRF
A
W
E
V
RQER
D
Q
L
F
V
G
DD
A
IRV
L
H
ER
SLQ
S
LPW
R
E
L
GVDVV
L
D
CTG
V
Y
G
S
R
E
HG
EAHI
A
AGAKKVL
F
S
H
P
G
S
N
D
LDA
T
V
VYGVN
Q
D
Q
L
R
A
E
H
R
IVSNASCTTNC
II
PV
I
K
L
LDDA
Y
GIE
S
GT
V
TTIH
S
A
M
H
D
Q
QV
I
D
A
-
Y
H
P
DLR
RT
RAASQ
S
IIP
VD
T
KL
A
AG
I
T
R
F
F
P
QF
N
DRF
E
A
I
A
V
RVPT
I
NV
TA
I
DL
S
V
T
V
K
K
P
V
K
A
N
EVN
L
L
L
Q
K
AA
Q
G
AFH
G
IV
D
YTE
LP
LVS
V
DFN
H
DPHS
AIV
D
G
TQ
-
--
T
R
V
S
G
AH
L
I
KT
L
V
W
C
DNE
W
GF
A
NRMLD
fig|362663.9.peg.2956
Escherichia coli 536 (1-328/339)
MTV
R
V
A
INGFGRIGR
N
V
V
R
A
L
Y
E
SG
R
R
A
EI
T
VVAIN
E
L
A
DA
AG
MA
H
LLKYD
T
SHGRF
A
W
E
V
RQER
D
Q
L
F
V
G
DD
A
IRV
L
H
ER
SLQ
S
LPW
R
E
L
GVDVV
L
D
CTG
V
Y
G
S
R
E
HG
EAHI
A
AGAKKVL
F
S
H
P
G
S
N
D
LDA
T
V
VYGVN
Q
D
Q
L
R
A
E
H
R
IVSNASCTTNC
II
PV
I
K
L
LDDA
Y
GIE
S
GT
V
TTIH
S
A
M
H
D
Q
QV
I
D
A
-
Y
H
P
DLR
RT
RAASQ
S
IIP
VD
T
KL
A
AG
I
T
R
F
F
P
QF
N
DRF
E
A
I
A
V
RVPT
I
NV
TA
I
DL
S
V
T
V
K
K
P
V
K
A
N
EVN
L
L
L
Q
K
AA
Q
G
AFH
G
IV
D
YTE
LP
LVS
V
DFN
H
DPHS
AIV
D
G
TQ
-
--
T
R
V
S
G
AH
L
I
KT
L
V
W
C
DNE
W
GF
A
NRMLD
fig|344610.3.peg.935
Escherichia coli 53638 (1-328/339)
MTV
R
V
A
INGFGRIGR
N
V
V
R
A
L
Y
E
SG
R
R
A
EI
T
VVAIN
E
L
A
DA
AG
MA
H
LLKYD
T
SHGRF
A
W
E
V
RQER
D
Q
L
F
V
G
DD
A
IRV
L
H
ER
SLQ
S
LPW
R
E
L
GVDVV
L
D
CTG
V
Y
G
S
R
E
HG
EAHI
A
AGAKKVL
F
S
H
P
G
S
N
D
LDA
T
V
VYGVN
Q
D
Q
L
R
A
E
H
R
IVSNASCTTNC
II
PV
I
K
L
LDDA
Y
GIE
S
GT
V
TTIH
S
A
M
H
D
Q
QV
I
D
A
-
Y
H
P
DLR
RT
RAASQ
S
IIP
VD
T
KL
A
AG
I
T
R
F
F
P
QF
N
DRF
E
A
I
A
V
RVPT
I
NV
TA
I
DL
S
V
T
V
K
K
P
V
K
A
N
EVN
L
L
L
Q
K
AA
Q
G
AFH
G
IV
D
YTE
LP
LVS
V
DFN
H
DPHS
AIV
D
G
TQ
-
--
T
R
V
S
G
AH
L
I
KT
L
V
W
C
DNE
W
GF
A
NRMLD
fig|344610.7.peg.3341
Escherichia coli 53638 (1-328/339)
MTV
R
V
A
INGFGRIGR
N
V
V
R
A
L
Y
E
SG
R
R
A
EI
T
VVAIN
E
L
A
DA
AG
MA
H
LLKYD
T
SHGRF
A
W
E
V
RQER
D
Q
L
F
V
G
DD
A
IRV
L
H
ER
SLQ
S
LPW
R
E
L
GVDVV
L
D
CTG
V
Y
G
S
R
E
HG
EAHI
A
AGAKKVL
F
S
H
P
G
S
N
D
LDA
T
V
VYGVN
Q
D
Q
L
R
A
E
H
R
IVSNASCTTNC
II
PV
I
K
L
LDDA
Y
GIE
S
GT
V
TTIH
S
A
M
H
D
Q
QV
I
D
A
-
Y
H
P
DLR
RT
RAASQ
S
IIP
VD
T
KL
A
AG
I
T
R
F
F
P
QF
N
DRF
E
A
I
A
V
RVPT
I
NV
TA
I
DL
S
V
T
V
K
K
P
V
K
A
N
EVN
L
L
L
Q
K
AA
Q
G
AFH
G
IV
D
YTE
LP
LVS
V
DFN
H
DPHS
AIV
D
G
TQ
-
--
T
R
V
S
G
AH
L
I
KT
L
V
W
C
DNE
W
GF
A
NRMLD
fig|562.374.peg.4472
Escherichia coli 536A (1-328/339)
MTV
R
V
A
INGFGRIGR
N
V
V
R
A
L
Y
E
SG
R
R
A
EI
T
VVAIN
E
L
A
DA
AG
MA
H
LLKYD
T
SHGRF
A
W
E
V
RQER
D
Q
L
F
V
G
DD
A
IRV
L
H
ER
SLQ
S
LPW
R
E
L
GVDVV
L
D
CTG
V
Y
G
S
R
E
HG
EAHI
A
AGAKKVL
F
S
H
P
G
S
N
D
LDA
T
V
VYGVN
Q
D
Q
L
R
A
E
H
R
IVSNASCTTNC
II
PV
I
K
L
LDDA
Y
GIE
S
GT
V
TTIH
S
A
M
H
D
Q
QV
I
D
A
-
Y
H
P
DLR
RT
RAASQ
S
IIP
VD
T
KL
A
AG
I
T
R
F
F
P
QF
N
DRF
E
A
I
A
V
RVPT
I
NV
TA
I
DL
S
V
T
V
K
K
P
V
K
A
N
EVN
L
L
L
Q
K
AA
Q
G
AFH
G
IV
D
YTE
LP
LVS
V
DFN
H
DPHS
AIV
D
G
TQ
-
--
T
R
V
S
G
AH
L
I
KT
L
V
W
C
DNE
W
GF
A
NRMLD
fig|585055.6.peg.3251
Escherichia coli 55989 (1-328/339)
MTV
R
V
A
INGFGRIGR
N
V
V
R
A
L
Y
E
SG
R
R
A
EI
T
VVAIN
E
L
A
DA
AG
MA
H
LLKYD
T
SHGRF
A
W
E
V
RQER
D
Q
L
F
V
G
DD
A
IRV
L
H
ER
SLQ
S
LPW
R
E
L
GVDVV
L
D
CTG
V
Y
G
S
R
E
HG
EAHI
A
AGAKKVL
F
S
H
P
G
S
N
D
LDA
T
V
VYGVN
Q
D
Q
L
R
A
E
H
R
IVSNASCTTNC
II
PV
I
K
L
LDDA
Y
GIE
S
GT
V
TTIH
S
A
M
H
D
Q
QV
I
D
A
-
Y
H
P
DLR
RT
RAASQ
S
IIP
VD
T
KL
A
AG
I
T
R
F
F
P
QF
N
DRF
E
A
I
A
V
RVPT
I
NV
TA
I
DL
S
V
T
V
K
K
P
V
K
A
N
EVN
L
L
L
Q
K
AA
Q
G
AFH
G
IV
D
YTE
LP
LVS
V
DFN
H
DPHS
AIV
D
G
TQ
-
--
T
R
V
S
G
AH
L
I
KT
L
V
W
C
DNE
W
GF
A
NRMLD
fig|585055.8.peg.3255
Escherichia coli 55989 (1-328/339)
MTV
R
V
A
INGFGRIGR
N
V
V
R
A
L
Y
E
SG
R
R
A
EI
T
VVAIN
E
L
A
DA
AG
MA
H
LLKYD
T
SHGRF
A
W
E
V
RQER
D
Q
L
F
V
G
DD
A
IRV
L
H
ER
SLQ
S
LPW
R
E
L
GVDVV
L
D
CTG
V
Y
G
S
R
E
HG
EAHI
A
AGAKKVL
F
S
H
P
G
S
N
D
LDA
T
V
VYGVN
Q
D
Q
L
R
A
E
H
R
IVSNASCTTNC
II
PV
I
K
L
LDDA
Y
GIE
S
GT
V
TTIH
S
A
M
H
D
Q
QV
I
D
A
-
Y
H
P
DLR
RT
RAASQ
S
IIP
VD
T
KL
A
AG
I
T
R
F
F
P
QF
N
DRF
E
A
I
A
V
RVPT
I
NV
TA
I
DL
S
V
T
V
K
K
P
V
K
A
N
EVN
L
L
L
Q
K
AA
Q
G
AFH
G
IV
D
YTE
LP
LVS
V
DFN
H
DPHS
AIV
D
G
TQ
-
--
T
R
V
S
G
AH
L
I
KT
L
V
W
C
DNE
W
GF
A
NRMLD
fig|525281.3.peg.4664
Escherichia coli 83972 (1-328/339)
MTV
R
V
A
INGFGRIGR
N
V
V
R
A
L
Y
E
SG
R
R
A
EI
T
VVAIN
E
L
A
DA
AG
MA
H
LLKYD
T
SHGRF
A
W
E
V
RQER
D
Q
L
F
V
G
DD
A
IRV
L
H
ER
SLQ
S
LPW
R
E
L
GVDVV
L
D
CTG
V
Y
G
S
R
E
HG
EAHI
A
AGAKKVL
F
S
H
P
G
S
N
D
LDA
T
V
VYGVN
Q
D
Q
L
R
A
E
H
R
IVSNASCTTNC
II
PV
I
K
L
LDDA
Y
GIE
S
GT
V
TTIH
S
A
M
H
D
Q
QV
I
D
A
-
Y
H
P
DLR
RT
RAASQ
S
IIP
VD
T
KL
A
AG
I
T
R
F
F
P
QF
N
DRF
E
A
I
A
V
RVPT
I
NV
TA
I
DL
S
V
T
V
K
K
P
V
K
A
N
EVN
L
L
L
Q
K
AA
Q
G
AFH
G
IV
D
YTE
LP
LVS
V
DFN
H
DPHS
AIV
D
G
TQ
-
--
T
R
V
S
G
AH
L
I
KT
L
V
W
C
DNE
W
GF
A
NRMLD
fig|655817.3.peg.3332
Escherichia coli ABU 83972 (1-328/339)
MTV
R
V
A
INGFGRIGR
N
V
V
R
A
L
Y
E
SG
R
R
A
EI
T
VVAIN
E
L
A
DA
AG
MA
H
LLKYD
T
SHGRF
A
W
E
V
RQER
D
Q
L
F
V
G
DD
A
IRV
L
H
ER
SLQ
S
LPW
R
E
L
GVDVV
L
D
CTG
V
Y
G
S
R
E
HG
EAHI
A
AGAKKVL
F
S
H
P
G
S
N
D
LDA
T
V
VYGVN
Q
D
Q
L
R
A
E
H
R
IVSNASCTTNC
II
PV
I
K
L
LDDA
Y
GIE
S
GT
V
TTIH
S
A
M
H
D
Q
QV
I
D
A
-
Y
H
P
DLR
RT
RAASQ
S
IIP
VD
T
KL
A
AG
I
T
R
F
F
P
QF
N
DRF
E
A
I
A
V
RVPT
I
NV
TA
I
DL
S
V
T
V
K
K
P
V
K
A
N
EVN
L
L
L
Q
K
AA
Q
G
AFH
G
IV
D
YTE
LP
LVS
V
DFN
H
DPHS
AIV
D
G
TQ
-
--
T
R
V
S
G
AH
L
I
KT
L
V
W
C
DNE
W
GF
A
NRMLD
fig|481805.3.peg.834
Escherichia coli ATCC 8739 (29-356/367)
MTV
R
V
A
INGFGRIGR
N
V
V
R
A
L
Y
E
SG
R
R
A
EI
T
VVAIN
E
L
A
DA
AG
MA
H
LLKYD
T
SHGRF
A
W
E
V
RQER
D
Q
L
F
V
G
DD
A
IRV
L
H
ER
SLQ
S
LPW
R
E
L
GVDVV
L
D
CTG
V
Y
G
S
R
E
HG
EAHI
A
AGAKKVL
F
S
H
P
G
S
N
D
LDA
T
V
VYGVN
Q
D
Q
L
R
A
E
H
R
IVSNASCTTNC
II
PV
I
K
L
LDDA
Y
GIE
S
GT
V
TTIH
S
A
M
H
D
Q
QV
I
D
A
-
Y
H
P
DLR
RT
RAASQ
S
IIP
VD
T
KL
A
AG
I
T
R
F
F
P
QF
N
DRF
E
A
I
A
V
RVPT
I
NV
TA
I
DL
S
V
T
V
K
K
P
V
K
A
N
EVN
L
L
L
Q
K
AA
Q
G
AFH
G
IV
D
YTE
LP
LVS
V
DFN
H
DPHS
AIV
D
G
TQ
-
--
T
R
V
S
G
AH
L
I
KT
L
V
W
C
DNE
W
GF
A
NRMLD
fig|481805.6.peg.830
Escherichia coli ATCC 8739 (1-328/339)
MTV
R
V
A
INGFGRIGR
N
V
V
R
A
L
Y
E
SG
R
R
A
EI
T
VVAIN
E
L
A
DA
AG
MA
H
LLKYD
T
SHGRF
A
W
E
V
RQER
D
Q
L
F
V
G
DD
A
IRV
L
H
ER
SLQ
S
LPW
R
E
L
GVDVV
L
D
CTG
V
Y
G
S
R
E
HG
EAHI
A
AGAKKVL
F
S
H
P
G
S
N
D
LDA
T
V
VYGVN
Q
D
Q
L
R
A
E
H
R
IVSNASCTTNC
II
PV
I
K
L
LDDA
Y
GIE
S
GT
V
TTIH
S
A
M
H
D
Q
QV
I
D
A
-
Y
H
P
DLR
RT
RAASQ
S
IIP
VD
T
KL
A
AG
I
T
R
F
F
P
QF
N
DRF
E
A
I
A
V
RVPT
I
NV
TA
I
DL
S
V
T
V
K
K
P
V
K
A
N
EVN
L
L
L
Q
K
AA
Q
G
AFH
G
IV
D
YTE
LP
LVS
V
DFN
H
DPHS
AIV
D
G
TQ
-
--
T
R
V
S
G
AH
L
I
KT
L
V
W
C
DNE
W
GF
A
NRMLD
fig|413997.3.peg.2893
Escherichia coli B str. REL606 (1-328/339)
MTV
R
V
A
INGFGRIGR
N
V
V
R
A
L
Y
E
SG
R
R
A
EI
T
VVAIN
E
L
A
DA
AG
MA
H
LLKYD
T
SHGRF
A
W
E
V
RQER
D
Q
L
F
V
G
DD
A
IRV
L
H
ER
SLQ
S
LPW
R
E
L
GVDVV
L
D
CTG
V
Y
G
S
R
E
HG
EAHI
A
AGAKKVL
F
S
H
P
G
S
N
D
LDA
T
V
VYGVN
Q
D
Q
L
R
A
E
H
R
IVSNASCTTNC
II
PV
I
K
L
LDDA
Y
GIE
S
GT
V
TTIH
S
A
M
H
D
Q
QV
I
D
A
-
Y
H
P
DLR
RT
RAASQ
S
IIP
VD
T
KL
A
AG
I
T
R
F
F
P
QF
N
DRF
E
A
I
A
V
RVPT
I
NV
TA
I
DL
S
V
T
V
K
K
P
V
K
A
N
EVN
L
L
L
Q
K
AA
Q
G
AFH
G
IV
D
YTE
LP
LVS
V
DFN
H
DPHS
AIV
D
G
TQ
-
--
T
R
V
S
G
AH
L
I
KT
L
V
W
C
DNE
W
GF
A
NRMLD
fig|550672.3.peg.3144
Escherichia coli B088 (1-328/339)
MTV
R
V
A
INGFGRIGR
N
V
V
R
A
L
Y
E
SG
R
R
A
EI
T
VVAIN
E
L
A
DA
AG
MA
H
LLKYD
T
SHGRF
A
W
E
V
RQER
D
Q
L
F
V
G
DD
A
IRV
L
H
ER
SLQ
S
LPW
R
E
L
GVDVV
L
D
CTG
V
Y
G
S
R
E
HG
EAHI
A
AGAKKVL
F
S
H
P
G
S
N
D
LDA
T
V
VYGVN
Q
D
Q
L
R
A
E
H
R
IVSNASCTTNC
II
PV
I
K
L
LDDA
Y
GIE
S
GT
V
TTIH
S
A
M
H
D
Q
QV
I
D
A
-
Y
H
P
DLR
RT
RAASQ
S
IIP
VD
T
KL
A
AG
I
T
R
F
F
P
QF
N
DRF
E
A
I
A
V
RVPT
I
NV
TA
I
DL
S
V
T
V
K
K
P
V
K
A
N
EVN
L
L
L
Q
K
AA
Q
G
AFH
G
IV
D
YTE
LP
LVS
V
DFN
H
DPHS
AIV
D
G
TQ
-
--
T
R
V
S
G
AH
L
I
KT
L
V
W
C
DNE
W
GF
A
NRMLD
fig|344601.3.peg.599
Escherichia coli B171 (1-328/339)
MTV
R
V
A
INGFGRIGR
N
V
V
R
A
L
Y
E
SG
R
R
A
EI
T
VVAIN
E
L
A
DA
AG
MA
H
LLKYD
T
SHGRF
A
W
E
V
RQER
D
Q
L
F
V
G
DD
A
IRV
L
H
ER
SLQ
S
LPW
R
E
L
GVDVV
L
D
CTG
V
Y
G
S
R
E
HG
EAHI
A
AGAKKVL
F
S
H
P
G
S
N
D
LDA
T
V
VYGVN
Q
D
Q
L
R
A
E
H
R
IVSNASCTTNC
II
PV
I
K
L
LDDA
Y
GIE
S
GT
V
TTIH
S
A
M
H
D
Q
QV
I
D
A
-
Y
H
P
DLR
RT
RAASQ
S
IIP
VD
T
KL
A
AG
I
T
R
F
F
P
QF
N
DRF
E
A
I
A
V
RVPT
I
NV
TA
I
DL
S
V
T
V
K
K
P
V
K
A
N
EVN
L
L
L
Q
K
AA
Q
G
AFH
G
IV
D
YTE
LP
LVS
V
DFN
H
DPHS
AIV
D
G
TQ
-
--
T
R
V
S
G
AH
L
I
KT
L
V
W
C
DNE
W
GF
A
NRMLD
fig|344601.5.peg.611
Escherichia coli B171 (1-328/339)
MTV
R
V
A
INGFGRIGR
N
V
V
R
A
L
Y
E
SG
R
R
A
EI
T
VVAIN
E
L
A
DA
AG
MA
H
LLKYD
T
SHGRF
A
W
E
V
RQER
D
Q
L
F
V
G
DD
A
IRV
L
H
ER
SLQ
S
LPW
R
E
L
GVDVV
L
D
CTG
V
Y
G
S
R
E
HG
EAHI
A
AGAKKVL
F
S
H
P
G
S
N
D
LDA
T
V
VYGVN
Q
D
Q
L
R
A
E
H
R
IVSNASCTTNC
II
PV
I
K
L
LDDA
Y
GIE
S
GT
V
TTIH
S
A
M
H
D
Q
QV
I
D
A
-
Y
H
P
DLR
RT
RAASQ
S
IIP
VD
T
KL
A
AG
I
T
R
F
F
P
QF
N
DRF
E
A
I
A
V
RVPT
I
NV
TA
I
DL
S
V
T
V
K
K
P
V
K
A
N
EVN
L
L
L
Q
K
AA
Q
G
AFH
G
IV
D
YTE
LP
LVS
V
DFN
H
DPHS
AIV
D
G
TQ
-
--
T
R
V
S
G
AH
L
I
KT
L
V
W
C
DNE
W
GF
A
NRMLD
fig|550676.3.peg.2874
Escherichia coli B185 (1-328/339)
MTV
R
V
A
INGFGRIGR
N
V
V
R
A
L
Y
E
SG
R
R
A
EI
T
VVAIN
E
L
A
DA
AG
MA
H
LLKYD
T
SHGRF
A
W
E
V
RQER
D
Q
L
F
V
G
DD
A
IRV
L
H
ER
SLQ
S
LPW
R
E
L
GVDVV
L
D
CTG
V
Y
G
S
R
E
HG
EAHI
A
AGAKKVL
F
S
H
P
G
S
N
D
LDA
T
V
VYGVN
Q
D
Q
L
R
A
E
H
R
IVSNASCTTNC
II
PV
I
K
L
LDDA
Y
GIE
S
GT
V
TTIH
S
A
M
H
D
Q
QV
I
D
A
-
Y
H
P
DLR
RT
RAASQ
S
IIP
VD
T
KL
A
AG
I
T
R
F
F
P
QF
N
DRF
E
A
I
A
V
RVPT
I
NV
TA
I
DL
S
V
T
V
K
K
P
V
K
A
N
EVN
L
L
L
Q
K
AA
Q
G
AFH
G
IV
D
YTE
LP
LVS
V
DFN
H
DPHS
AIV
D
G
TQ
-
--
T
R
V
S
G
AH
L
I
KT
L
V
W
C
DNE
W
GF
A
NRMLD
fig|550677.3.peg.3472
Escherichia coli B354 (1-328/339)
MTV
R
V
A
INGFGRIGR
N
V
V
R
A
L
Y
E
SG
R
R
A
EI
T
VVAIN
E
L
A
DA
AG
MA
H
LLKYD
T
SHGRF
A
W
E
V
RQER
D
Q
L
F
V
G
DD
A
IRV
L
H
ER
SLQ
S
LPW
R
E
L
GVDVV
L
D
CTG
V
Y
G
S
R
E
HG
EAHI
A
AGAKKVL
F
S
H
P
G
S
N
D
LDA
T
V
VYGVN
Q
D
Q
L
R
A
E
H
R
IVSNASCTTNC
II
PV
I
K
L
LDDA
Y
GIE
S
GT
V
TTIH
S
A
M
H
D
Q
QV
I
D
A
-
Y
H
P
DLR
RT
RAASQ
S
IIP
VD
T
KL
A
AG
I
T
R
F
F
P
QF
N
DRF
E
A
I
A
V
RVPT
I
NV
TA
I
DL
S
V
T
V
K
K
P
V
K
A
N
EVN
L
L
L
Q
K
AA
Q
G
AFH
G
IV
D
YTE
LP
LVS
V
DFN
H
DPHS
AIV
D
G
TQ
-
--
T
R
V
S
G
AH
L
I
KT
L
V
W
C
DNE
W
GF
A
NRMLD
fig|340184.3.peg.3308
Escherichia coli B7A (1-328/339)
MTV
R
V
A
INGFGRIGR
N
V
V
R
A
L
Y
E
SG
R
R
A
EI
T
VVAIN
E
L
A
DA
AG
MA
H
LLKYD
T
SHGRF
A
W
E
V
RQER
D
Q
L
F
V
G
DD
A
IRV
L
H
ER
SLQ
S
LPW
R
E
L
GVDVV
L
D
CTG
V
Y
G
S
R
E
HG
EAHI
A
AGAKKVL
F
S
H
P
G
S
N
D
LDA
T
V
VYGVN
Q
D
Q
L
R
A
E
H
R
IVSNASCTTNC
II
PV
I
K
L
LDDA
Y
GIE
S
GT
V
TTIH
S
A
M
H
D
Q
QV
I
D
A
-
Y
H
P
DLR
RT
RAASQ
S
IIP
VD
T
KL
A
AG
I
T
R
F
F
P
QF
N
DRF
E
A
I
A
V
RVPT
I
NV
TA
I
DL
S
V
T
V
K
K
P
V
K
A
N
EVN
L
L
L
Q
K
AA
Q
G
AFH
G
IV
D
YTE
LP
LVS
V
DFN
H
DPHS
AIV
D
G
TQ
-
--
T
R
V
S
G
AH
L
I
KT
L
V
W
C
DNE
W
GF
A
NRMLD
fig|340184.6.peg.3454
Escherichia coli B7A (1-328/339)
MTV
R
V
A
INGFGRIGR
N
V
V
R
A
L
Y
E
SG
R
R
A
EI
T
VVAIN
E
L
A
DA
AG
MA
H
LLKYD
T
SHGRF
A
W
E
V
RQER
D
Q
L
F
V
G
DD
A
IRV
L
H
ER
SLQ
S
LPW
R
E
L
GVDVV
L
D
CTG
V
Y
G
S
R
E
HG
EAHI
A
AGAKKVL
F
S
H
P
G
S
N
D
LDA
T
V
VYGVN
Q
D
Q
L
R
A
E
H
R
IVSNASCTTNC
II
PV
I
K
L
LDDA
Y
GIE
S
GT
V
TTIH
S
A
M
H
D
Q
QV
I
D
A
-
Y
H
P
DLR
RT
RAASQ
S
IIP
VD
T
KL
A
AG
I
T
R
F
F
P
QF
N
DRF
E
A
I
A
V
RVPT
I
NV
TA
I
DL
S
V
T
V
K
K
P
V
K
A
N
EVN
L
L
L
Q
K
AA
Q
G
AFH
G
IV
D
YTE
LP
LVS
V
DFN
H
DPHS
AIV
D
G
TQ
-
--
T
R
V
S
G
AH
L
I
KT
L
V
W
C
DNE
W
GF
A
NRMLD
fig|511693.5.peg.2914
Escherichia coli BL21 (1-328/339)
MTV
R
V
A
INGFGRIGR
N
V
V
R
A
L
Y
E
SG
R
R
A
EI
T
VVAIN
E
L
A
DA
AG
MA
H
LLKYD
T
SHGRF
A
W
E
V
RQER
D
Q
L
F
V
G
DD
A
IRV
L
H
ER
SLQ
S
LPW
R
E
L
GVDVV
L
D
CTG
V
Y
G
S
R
E
HG
EAHI
A
AGAKKVL
F
S
H
P
G
S
N
D
LDA
T
V
VYGVN
Q
D
Q
L
R
A
E
H
R
IVSNASCTTNC
II
PV
I
K
L
LDDA
Y
GIE
S
GT
V
TTIH
S
A
M
H
D
Q
QV
I
D
A
-
Y
H
P
DLR
RT
RAASQ
S
IIP
VD
T
KL
A
AG
I
T
R
F
F
P
QF
N
DRF
E
A
I
A
V
RVPT
I
NV
TA
I
DL
S
V
T
V
K
K
P
V
K
A
N
EVN
L
L
L
Q
K
AA
Q
G
AFH
G
IV
D
YTE
LP
LVS
V
DFN
H
DPHS
AIV
D
G
TQ
-
--
T
R
V
S
G
AH
L
I
KT
L
V
W
C
DNE
W
GF
A
NRMLD
fig|469008.4.peg.827
Escherichia coli BL21(DE3) (1-328/339)
MTV
R
V
A
INGFGRIGR
N
V
V
R
A
L
Y
E
SG
R
R
A
EI
T
VVAIN
E
L
A
DA
AG
MA
H
LLKYD
T
SHGRF
A
W
E
V
RQER
D
Q
L
F
V
G
DD
A
IRV
L
H
ER
SLQ
S
LPW
R
E
L
GVDVV
L
D
CTG
V
Y
G
S
R
E
HG
EAHI
A
AGAKKVL
F
S
H
P
G
S
N
D
LDA
T
V
VYGVN
Q
D
Q
L
R
A
E
H
R
IVSNASCTTNC
II
PV
I
K
L
LDDA
Y
GIE
S
GT
V
TTIH
S
A
M
H
D
Q
QV
I
D
A
-
Y
H
P
DLR
RT
RAASQ
S
IIP
VD
T
KL
A
AG
I
T
R
F
F
P
QF
N
DRF
E
A
I
A
V
RVPT
I
NV
TA
I
DL
S
V
T
V
K
K
P
V
K
A
N
EVN
L
L
L
Q
K
AA
Q
G
AFH
G
IV
D
YTE
LP
LVS
V
DFN
H
DPHS
AIV
D
G
TQ
-
--
T
R
V
S
G
AH
L
I
KT
L
V
W
C
DNE
W
GF
A
NRMLD
fig|595496.3.peg.2905
Escherichia coli BW2952 (1-328/339)
MTV
R
V
A
INGFGRIGR
N
V
V
R
A
L
Y
E
SG
R
R
A
EI
T
VVAIN
E
L
A
DA
AG
MA
H
LLKYD
T
SHGRF
A
W
E
V
RQER
D
Q
L
F
V
G
DD
A
IRV
L
H
ER
SLQ
S
LPW
R
E
L
GVDVV
L
D
CTG
V
Y
G
S
R
E
HG
EAHI
A
AGAKKVL
F
S
H
P
G
S
N
D
LDA
T
V
VYGVN
Q
D
Q
L
R
A
E
H
R
IVSNASCTTNC
II
PV
I
K
L
LDDA
Y
GIE
S
GT
V
TTIH
S
A
M
H
D
Q
QV
I
D
A
-
Y
H
P
DLR
RT
RAASQ
S
IIP
VD
T
KL
A
AG
I
T
R
F
F
P
QF
N
DRF
E
A
I
A
V
RVPT
I
NV
TA
I
DL
S
V
T
V
K
K
P
V
K
A
N
EVN
L
L
L
Q
K
AA
Q
G
AFH
G
IV
D
YTE
LP
LVS
V
DFN
H
DPHS
AIV
D
G
TQ
-
--
T
R
V
S
G
AH
L
I
KT
L
V
W
C
DNE
W
GF
A
NRMLD
fig|199310.1.peg.3423
Escherichia coli CFT073 (29-356/367)
MTV
R
V
A
INGFGRIGR
N
V
V
R
A
L
Y
E
SG
R
R
A
EI
T
VVAIN
E
L
A
DA
AG
MA
H
LLKYD
T
SHGRF
A
W
E
V
RQER
D
Q
L
F
V
G
DD
A
IRV
L
H
ER
SLQ
S
LPW
R
E
L
GVDVV
L
D
CTG
V
Y
G
S
R
E
HG
EAHI
A
AGAKKVL
F
S
H
P
G
S
N
D
LDA
T
V
VYGVN
Q
D
Q
L
R
A
E
H
R
IVSNASCTTNC
II
PV
I
K
L
LDDA
Y
GIE
S
GT
V
TTIH
S
A
M
H
D
Q
QV
I
D
A
-
Y
H
P
DLR
RT
RAASQ
S
IIP
VD
T
KL
A
AG
I
T
R
F
F
P
QF
N
DRF
E
A
I
A
V
RVPT
I
NV
TA
I
DL
S
V
T
V
K
K
P
V
K
A
N
EVN
L
L
L
Q
K
AA
Q
G
AFH
G
IV
D
YTE
LP
LVS
V
DFN
H
DPHS
AIV
D
G
TQ
-
--
T
R
V
S
G
AH
L
I
KT
L
V
W
C
DNE
W
GF
A
NRMLD
fig|199310.4.peg.3301
Escherichia coli CFT073 (1-328/339)
MTV
R
V
A
INGFGRIGR
N
V
V
R
A
L
Y
E
SG
R
R
A
EI
T
VVAIN
E
L
A
DA
AG
MA
H
LLKYD
T
SHGRF
A
W
E
V
RQER
D
Q
L
F
V
G
DD
A
IRV
L
H
ER
SLQ
S
LPW
R
E
L
GVDVV
L
D
CTG
V
Y
G
S
R
E
HG
EAHI
A
AGAKKVL
F
S
H
P
G
S
N
D
LDA
T
V
VYGVN
Q
D
Q
L
R
A
E
H
R
IVSNASCTTNC
II
PV
I
K
L
LDDA
Y
GIE
S
GT
V
TTIH
S
A
M
H
D
Q
QV
I
D
A
-
Y
H
P
DLR
RT
RAASQ
S
IIP
VD
T
KL
A
AG
I
T
R
F
F
P
QF
N
DRF
E
A
I
A
V
RVPT
I
NV
TA
I
DL
S
V
T
V
K
K
P
V
K
A
N
EVN
L
L
L
Q
K
AA
Q
G
AFH
G
IV
D
YTE
LP
LVS
V
DFN
H
DPHS
AIV
D
G
TQ
-
--
T
R
V
S
G
AH
L
I
KT
L
V
W
C
DNE
W
GF
A
NRMLD
fig|536056.3.peg.804
Escherichia coli DH1 (1-328/339)
MTV
R
V
A
INGFGRIGR
N
V
V
R
A
L
Y
E
SG
R
R
A
EI
T
VVAIN
E
L
A
DA
AG
MA
H
LLKYD
T
SHGRF
A
W
E
V
RQER
D
Q
L
F
V
G
DD
A
IRV
L
H
ER
SLQ
S
LPW
R
E
L
GVDVV
L
D
CTG
V
Y
G
S
R
E
HG
EAHI
A
AGAKKVL
F
S
H
P
G
S
N
D
LDA
T
V
VYGVN
Q
D
Q
L
R
A
E
H
R
IVSNASCTTNC
II
PV
I
K
L
LDDA
Y
GIE
S
GT
V
TTIH
S
A
M
H
D
Q
QV
I
D
A
-
Y
H
P
DLR
RT
RAASQ
S
IIP
VD
T
KL
A
AG
I
T
R
F
F
P
QF
N
DRF
E
A
I
A
V
RVPT
I
NV
TA
I
DL
S
V
T
V
K
K
P
V
K
A
N
EVN
L
L
L
Q
K
AA
Q
G
AFH
G
IV
D
YTE
LP
LVS
V
DFN
H
DPHS
AIV
D
G
TQ
-
--
T
R
V
S
G
AH
L
I
KT
L
V
W
C
DNE
W
GF
A
NRMLD
fig|340186.3.peg.625
Escherichia coli E110019 (1-328/339)
MTV
R
V
A
INGFGRIGR
N
V
V
R
A
L
Y
E
SG
R
R
A
EI
T
VVAIN
E
L
A
DA
AG
MA
H
LLKYD
T
SHGRF
A
W
E
V
RQER
D
Q
L
F
V
G
DD
A
IRV
L
H
ER
SLQ
S
LPW
R
E
L
GVDVV
L
D
CTG
V
Y
G
S
R
E
HG
EAHI
A
AGAKKVL
F
S
H
P
G
S
N
D
LDA
T
V
VYGVN
Q
D
Q
L
R
A
E
H
R
IVSNASCTTNC
II
PV
I
K
L
LDDA
Y
GIE
S
GT
V
TTIH
S
A
M
H
D
Q
QV
I
D
A
-
Y
H
P
DLR
RT
RAASQ
S
IIP
VD
T
KL
A
AG
I
T
R
F
F
P
QF
N
DRF
E
A
I
A
V
RVPT
I
NV
TA
I
DL
S
V
T
V
K
K
P
V
K
A
N
EVN
L
L
L
Q
K
AA
Q
G
AFH
G
IV
D
YTE
LP
LVS
V
DFN
H
DPHS
AIV
D
G
TQ
-
--
T
R
V
S
G
AH
L
I
KT
L
V
W
C
DNE
W
GF
A
NRMLD
fig|340186.5.peg.648
Escherichia coli E110019 (1-328/339)
MTV
R
V
A
INGFGRIGR
N
V
V
R
A
L
Y
E
SG
R
R
A
EI
T
VVAIN
E
L
A
DA
AG
MA
H
LLKYD
T
SHGRF
A
W
E
V
RQER
D
Q
L
F
V
G
DD
A
IRV
L
H
ER
SLQ
S
LPW
R
E
L
GVDVV
L
D
CTG
V
Y
G
S
R
E
HG
EAHI
A
AGAKKVL
F
S
H
P
G
S
N
D
LDA
T
V
VYGVN
Q
D
Q
L
R
A
E
H
R
IVSNASCTTNC
II
PV
I
K
L
LDDA
Y
GIE
S
GT
V
TTIH
S
A
M
H
D
Q
QV
I
D
A
-
Y
H
P
DLR
RT
RAASQ
S
IIP
VD
T
KL
A
AG
I
T
R
F
F
P
QF
N
DRF
E
A
I
A
V
RVPT
I
NV
TA
I
DL
S
V
T
V
K
K
P
V
K
A
N
EVN
L
L
L
Q
K
AA
Q
G
AFH
G
IV
D
YTE
LP
LVS
V
DFN
H
DPHS
AIV
D
G
TQ
-
--
T
R
V
S
G
AH
L
I
KT
L
V
W
C
DNE
W
GF
A
NRMLD
fig|340185.3.peg.1908
Escherichia coli E22 (1-328/339)
MTV
R
V
A
INGFGRIGR
N
V
V
R
A
L
Y
E
SG
R
R
A
EI
T
VVAIN
E
L
A
DA
AG
MA
H
LLKYD
T
SHGRF
A
W
E
V
RQER
D
Q
L
F
V
G
DD
A
IRV
L
H
ER
SLQ
S
LPW
R
E
L
GVDVV
L
D
CTG
V
Y
G
S
R
E
HG
EAHI
A
AGAKKVL
F
S
H
P
G
S
N
D
LDA
T
V
VYGVN
Q
D
Q
L
R
A
E
H
R
IVSNASCTTNC
II
PV
I
K
L
LDDA
Y
GIE
S
GT
V
TTIH
S
A
M
H
D
Q
QV
I
D
A
-
Y
H
P
DLR
RT
RAASQ
S
IIP
VD
T
KL
A
AG
I
T
R
F
F
P
QF
N
DRF
E
A
I
A
V
RVPT
I
NV
TA
I
DL
S
V
T
V
K
K
P
V
K
A
N
EVN
L
L
L
Q
K
AA
Q
G
AFH
G
IV
D
YTE
LP
LVS
V
DFN
H
DPHS
AIV
D
G
TQ
-
--
T
R
V
S
G
AH
L
I
KT
L
V
W
C
DNE
W
GF
A
NRMLD
fig|340185.4.peg.2022
Escherichia coli E22 (1-328/339)
MTV
R
V
A
INGFGRIGR
N
V
V
R
A
L
Y
E
SG
R
R
A
EI
T
VVAIN
E
L
A
DA
AG
MA
H
LLKYD
T
SHGRF
A
W
E
V
RQER
D
Q
L
F
V
G
DD
A
IRV
L
H
ER
SLQ
S
LPW
R
E
L
GVDVV
L
D
CTG
V
Y
G
S
R
E
HG
EAHI
A
AGAKKVL
F
S
H
P
G
S
N
D
LDA
T
V
VYGVN
Q
D
Q
L
R
A
E
H
R
IVSNASCTTNC
II
PV
I
K
L
LDDA
Y
GIE
S
GT
V
TTIH
S
A
M
H
D
Q
QV
I
D
A
-
Y
H
P
DLR
RT
RAASQ
S
IIP
VD
T
KL
A
AG
I
T
R
F
F
P
QF
N
DRF
E
A
I
A
V
RVPT
I
NV
TA
I
DL
S
V
T
V
K
K
P
V
K
A
N
EVN
L
L
L
Q
K
AA
Q
G
AFH
G
IV
D
YTE
LP
LVS
V
DFN
H
DPHS
AIV
D
G
TQ
-
--
T
R
V
S
G
AH
L
I
KT
L
V
W
C
DNE
W
GF
A
NRMLD
fig|331111.12.peg.3529
Escherichia coli E24377A (1-328/339)
MTV
R
V
A
INGFGRIGR
N
V
V
R
A
L
Y
E
SG
R
R
A
EI
T
VVAIN
E
L
A
DA
AG
MA
H
LLKYD
T
SHGRF
A
W
E
V
RQER
D
Q
L
F
V
G
DD
A
IRV
L
H
ER
SLQ
S
LPW
R
E
L
GVDVV
L
D
CTG
V
Y
G
S
R
E
HG
EAHI
A
AGAKKVL
F
S
H
P
G
S
N
D
LDA
T
V
VYGVN
Q
D
Q
L
R
A
E
H
R
IVSNASCTTNC
II
PV
I
K
L
LDDA
Y
GIE
S
GT
V
TTIH
S
A
M
H
D
Q
QV
I
D
A
-
Y
H
P
DLR
RT
RAASQ
S
IIP
VD
T
KL
A
AG
I
T
R
F
F
P
QF
N
DRF
E
A
I
A
V
RVPT
I
NV
TA
I
DL
S
V
T
V
K
K
P
V
K
A
N
EVN
L
L
L
Q
K
AA
Q
G
AFH
G
IV
D
YTE
LP
LVS
V
DFN
H
DPHS
AIV
D
G
TQ
-
--
T
R
V
S
G
AH
L
I
KT
L
V
W
C
DNE
W
GF
A
NRMLD
fig|331111.3.peg.957
Escherichia coli E24377A (1-328/339)
MTV
R
V
A
INGFGRIGR
N
V
V
R
A
L
Y
E
SG
R
R
A
EI
T
VVAIN
E
L
A
DA
AG
MA
H
LLKYD
T
SHGRF
A
W
E
V
RQER
D
Q
L
F
V
G
DD
A
IRV
L
H
ER
SLQ
S
LPW
R
E
L
GVDVV
L
D
CTG
V
Y
G
S
R
E
HG
EAHI
A
AGAKKVL
F
S
H
P
G
S
N
D
LDA
T
V
VYGVN
Q
D
Q
L
R
A
E
H
R
IVSNASCTTNC
II
PV
I
K
L
LDDA
Y
GIE
S
GT
V
TTIH
S
A
M
H
D
Q
QV
I
D
A
-
Y
H
P
DLR
RT
RAASQ
S
IIP
VD
T
KL
A
AG
I
T
R
F
F
P
QF
N
DRF
E
A
I
A
V
RVPT
I
NV
TA
I
DL
S
V
T
V
K
K
P
V
K
A
N
EVN
L
L
L
Q
K
AA
Q
G
AFH
G
IV
D
YTE
LP
LVS
V
DFN
H
DPHS
AIV
D
G
TQ
-
--
T
R
V
S
G
AH
L
I
KT
L
V
W
C
DNE
W
GF
A
NRMLD
fig|316401.4.peg.3530
Escherichia coli ETEC H10407 (1-328/339)
MTV
R
V
A
INGFGRIGR
N
V
V
R
A
L
Y
E
SG
R
R
A
EI
T
VVAIN
E
L
A
DA
AG
MA
H
LLKYD
T
SHGRF
A
W
E
V
RQER
D
Q
L
F
V
G
DD
A
IRV
L
H
ER
SLQ
S
LPW
R
E
L
GVDVV
L
D
CTG
V
Y
G
S
R
E
HG
EAHI
A
AGAKKVL
F
S
H
P
G
S
N
D
LDA
T
V
VYGVN
Q
D
Q
L
R
A
E
H
R
IVSNASCTTNC
II
PV
I
K
L
LDDA
Y
GIE
S
GT
V
TTIH
S
A
M
H
D
Q
QV
I
D
A
-
Y
H
P
DLR
RT
RAASQ
S
IIP
VD
T
KL
A
AG
I
T
R
F
F
P
QF
N
DRF
E
A
I
A
V
RVPT
I
NV
TA
I
DL
S
V
T
V
K
K
P
V
K
A
N
EVN
L
L
L
Q
K
AA
Q
G
AFH
G
IV
D
YTE
LP
LVS
V
DFN
H
DPHS
AIV
D
G
TQ
-
--
T
R
V
S
G
AH
L
I
KT
L
V
W
C
DNE
W
GF
A
NRMLD
fig|340197.3.peg.1988
Escherichia coli F11 (1-328/339)
MTV
R
V
A
INGFGRIGR
N
V
V
R
A
L
Y
E
SG
R
R
A
EI
T
VVAIN
E
L
A
DA
AG
MA
H
LLKYD
T
SHGRF
A
W
E
V
RQER
D
Q
L
F
V
G
DD
A
IRV
L
H
ER
SLQ
S
LPW
R
E
L
GVDVV
L
D
CTG
V
Y
G
S
R
E
HG
EAHI
A
AGAKKVL
F
S
H
P
G
S
N
D
LDA
T
V
VYGVN
Q
D
Q
L
R
A
E
H
R
IVSNASCTTNC
II
PV
I
K
L
LDDA
Y
GIE
S
GT
V
TTIH
S
A
M
H
D
Q
QV
I
D
A
-
Y
H
P
DLR
RT
RAASQ
S
IIP
VD
T
KL
A
AG
I
T
R
F
F
P
QF
N
DRF
E
A
I
A
V
RVPT
I
NV
TA
I
DL
S
V
T
V
K
K
P
V
K
A
N
EVN
L
L
L
Q
K
AA
Q
G
AFH
G
IV
D
YTE
LP
LVS
V
DFN
H
DPHS
AIV
D
G
TQ
-
--
T
R
V
S
G
AH
L
I
KT
L
V
W
C
DNE
W
GF
A
NRMLD
fig|340197.5.peg.2099
Escherichia coli F11 (1-328/339)
MTV
R
V
A
INGFGRIGR
N
V
V
R
A
L
Y
E
SG
R
R
A
EI
T
VVAIN
E
L
A
DA
AG
MA
H
LLKYD
T
SHGRF
A
W
E
V
RQER
D
Q
L
F
V
G
DD
A
IRV
L
H
ER
SLQ
S
LPW
R
E
L
GVDVV
L
D
CTG
V
Y
G
S
R
E
HG
EAHI
A
AGAKKVL
F
S
H
P
G
S
N
D
LDA
T
V
VYGVN
Q
D
Q
L
R
A
E
H
R
IVSNASCTTNC
II
PV
I
K
L
LDDA
Y
GIE
S
GT
V
TTIH
S
A
M
H
D
Q
QV
I
D
A
-
Y
H
P
DLR
RT
RAASQ
S
IIP
VD
T
KL
A
AG
I
T
R
F
F
P
QF
N
DRF
E
A
I
A
V
RVPT
I
NV
TA
I
DL
S
V
T
V
K
K
P
V
K
A
N
EVN
L
L
L
Q
K
AA
Q
G
AFH
G
IV
D
YTE
LP
LVS
V
DFN
H
DPHS
AIV
D
G
TQ
-
--
T
R
V
S
G
AH
L
I
KT
L
V
W
C
DNE
W
GF
A
NRMLD
fig|656379.3.peg.4315
Escherichia coli FVEC1302 (1-328/339)
MTV
R
V
A
INGFGRIGR
N
V
V
R
A
L
Y
E
SG
R
R
A
EI
T
VVAIN
E
L
A
DA
AG
MA
H
LLKYD
T
SHGRF
A
W
E
V
RQER
D
Q
L
F
V
G
DD
A
IRV
L
H
ER
SLQ
S
LPW
R
E
L
GVDVV
L
D
CTG
V
Y
G
S
R
E
HG
EAHI
A
AGAKKVL
F
S
H
P
G
S
N
D
LDA
T
V
VYGVN
Q
D
Q
L
R
A
E
H
R
IVSNASCTTNC
II
PV
I
K
L
LDDA
Y
GIE
S
GT
V
TTIH
S
A
M
H
D
Q
QV
I
D
A
-
Y
H
P
DLR
RT
RAASQ
S
IIP
VD
T
KL
A
AG
I
T
R
F
F
P
QF
N
DRF
E
A
I
A
V
RVPT
I
NV
TA
I
DL
S
V
T
V
K
K
P
V
K
A
N
EVN
L
L
L
Q
K
AA
Q
G
AFH
G
IV
D
YTE
LP
LVS
V
DFN
H
DPHS
AIV
D
G
TQ
-
--
T
R
V
S
G
AH
L
I
KT
L
V
W
C
DNE
W
GF
A
NRMLD
fig|656380.3.peg.4227
Escherichia coli FVEC1412 (1-328/339)
MTV
R
V
A
INGFGRIGR
N
V
V
R
A
L
Y
E
SG
R
R
A
EI
T
VVAIN
E
L
A
DA
AG
MA
H
LLKYD
T
SHGRF
A
W
E
V
RQER
D
Q
L
F
V
G
DD
A
IRV
L
H
ER
SLQ
S
LPW
R
E
L
GVDVV
L
D
CTG
V
Y
G
S
R
E
HG
EAHI
A
AGAKKVL
F
S
H
P
G
S
N
D
LDA
T
V
VYGVN
Q
D
Q
L
R
A
E
H
R
IVSNASCTTNC
II
PV
I
K
L
LDDA
Y
GIE
S
GT
V
TTIH
S
A
M
H
D
Q
QV
I
D
A
-
Y
H
P
DLR
RT
RAASQ
S
IIP
VD
T
KL
A
AG
I
T
R
F
F
P
QF
N
DRF
E
A
I
A
V
RVPT
I
NV
TA
I
DL
S
V
T
V
K
K
P
V
K
A
N
EVN
L
L
L
Q
K
AA
Q
G
AFH
G
IV
D
YTE
LP
LVS
V
DFN
H
DPHS
AIV
D
G
TQ
-
--
T
R
V
S
G
AH
L
I
KT
L
V
W
C
DNE
W
GF
A
NRMLD
fig|656393.3.peg.3939
Escherichia coli H299 (1-328/339)
MTV
R
V
A
INGFGRIGR
N
V
V
R
A
L
Y
E
SG
R
R
A
EI
T
VVAIN
E
L
A
DA
AG
MA
H
LLKYD
T
SHGRF
A
W
E
V
RQER
D
Q
L
F
V
G
DD
A
IRV
L
H
ER
SLQ
S
LPW
R
E
L
GVDVV
L
D
CTG
V
Y
G
S
R
E
HG
EAHI
A
AGAKKVL
F
S
H
P
G
S
N
D
LDA
T
V
VYGVN
Q
D
Q
L
R
A
E
H
R
IVSNASCTTNC
II
PV
I
K
L
LDDA
Y
GIE
S
GT
V
TTIH
S
A
M
H
D
Q
QV
I
D
A
-
Y
H
P
DLR
RT
RAASQ
S
IIP
VD
T
KL
A
AG
I
T
R
F
F
P
QF
N
DRF
E
A
I
A
V
RVPT
I
NV
TA
I
DL
S
V
T
V
K
K
P
V
K
A
N
EVN
L
L
L
Q
K
AA
Q
G
AFH
G
IV
D
YTE
LP
LVS
V
DFN
H
DPHS
AIV
D
G
TQ
-
--
T
R
V
S
G
AH
L
I
KT
L
V
W
C
DNE
W
GF
A
NRMLD
fig|656408.3.peg.3231
Escherichia coli H591 (1-328/339)
MTV
R
V
A
INGFGRIGR
N
V
V
R
A
L
Y
E
SG
R
R
A
EI
T
VVAIN
E
L
A
DA
AG
MA
H
LLKYD
T
SHGRF
A
W
E
V
RQER
D
Q
L
F
V
G
DD
A
IRV
L
H
ER
SLQ
S
LPW
R
E
L
GVDVV
L
D
CTG
V
Y
G
S
R
E
HG
EAHI
A
AGAKKVL
F
S
H
P
G
S
N
D
LDA
T
V
VYGVN
Q
D
Q
L
R
A
E
H
R
IVSNASCTTNC
II
PV
I
K
L
LDDA
Y
GIE
S
GT
V
TTIH
S
A
M
H
D
Q
QV
I
D
A
-
Y
H
P
DLR
RT
RAASQ
S
IIP
VD
T
KL
A
AG
I
T
R
F
F
P
QF
N
DRF
E
A
I
A
V
RVPT
I
NV
TA
I
DL
S
V
T
V
K
K
P
V
K
A
N
EVN
L
L
L
Q
K
AA
Q
G
AFH
G
IV
D
YTE
LP
LVS
V
DFN
H
DPHS
AIV
D
G
TQ
-
--
T
R
V
S
G
AH
L
I
KT
L
V
W
C
DNE
W
GF
A
NRMLD
fig|331112.3.peg.2881
Escherichia coli HS (1-328/339)
MTV
R
V
A
INGFGRIGR
N
V
V
R
A
L
Y
E
SG
R
R
A
EI
T
VVAIN
E
L
A
DA
AG
MA
H
LLKYD
T
SHGRF
A
W
E
V
RQER
D
Q
L
F
V
G
DD
A
IRV
L
H
ER
SLQ
S
LPW
R
E
L
GVDVV
L
D
CTG
V
Y
G
S
R
E
HG
EAHI
A
AGAKKVL
F
S
H
P
G
S
N
D
LDA
T
V
VYGVN
Q
D
Q
L
R
A
E
H
R
IVSNASCTTNC
II
PV
I
K
L
LDDA
Y
GIE
S
GT
V
TTIH
S
A
M
H
D
Q
QV
I
D
A
-
Y
H
P
DLR
RT
RAASQ
S
IIP
VD
T
KL
A
AG
I
T
R
F
F
P
QF
N
DRF
E
A
I
A
V
RVPT
I
NV
TA
I
DL
S
V
T
V
K
K
P
V
K
A
N
EVN
L
L
L
Q
K
AA
Q
G
AFH
G
IV
D
YTE
LP
LVS
V
DFN
H
DPHS
AIV
D
G
TQ
-
--
T
R
V
S
G
AH
L
I
KT
L
V
W
C
DNE
W
GF
A
NRMLD
fig|331112.6.peg.3015
Escherichia coli HS (1-328/339)
MTV
R
V
A
INGFGRIGR
N
V
V
R
A
L
Y
E
SG
R
R
A
EI
T
VVAIN
E
L
A
DA
AG
MA
H
LLKYD
T
SHGRF
A
W
E
V
RQER
D
Q
L
F
V
G
DD
A
IRV
L
H
ER
SLQ
S
LPW
R
E
L
GVDVV
L
D
CTG
V
Y
G
S
R
E
HG
EAHI
A
AGAKKVL
F
S
H
P
G
S
N
D
LDA
T
V
VYGVN
Q
D
Q
L
R
A
E
H
R
IVSNASCTTNC
II
PV
I
K
L
LDDA
Y
GIE
S
GT
V
TTIH
S
A
M
H
D
Q
QV
I
D
A
-
Y
H
P
DLR
RT
RAASQ
S
IIP
VD
T
KL
A
AG
I
T
R
F
F
P
QF
N
DRF
E
A
I
A
V
RVPT
I
NV
TA
I
DL
S
V
T
V
K
K
P
V
K
A
N
EVN
L
L
L
Q
K
AA
Q
G
AFH
G
IV
D
YTE
LP
LVS
V
DFN
H
DPHS
AIV
D
G
TQ
-
--
T
R
V
S
G
AH
L
I
KT
L
V
W
C
DNE
W
GF
A
NRMLD
fig|585034.4.peg.2989
Escherichia coli IAI1 (1-328/339)
MTV
R
V
A
INGFGRIGR
N
V
V
R
A
L
Y
E
SG
R
R
A
EI
T
VVAIN
E
L
A
DA
AG
MA
H
LLKYD
T
SHGRF
A
W
E
V
RQER
D
Q
L
F
V
G
DD
A
IRV
L
H
ER
SLQ
S
LPW
R
E
L
GVDVV
L
D
CTG
V
Y
G
S
R
E
HG
EAHI
A
AGAKKVL
F
S
H
P
G
S
N
D
LDA
T
V
VYGVN
Q
D
Q
L
R
A
E
H
R
IVSNASCTTNC
II
PV
I
K
L
LDDA
Y
GIE
S
GT
V
TTIH
S
A
M
H
D
Q
QV
I
D
A
-
Y
H
P
DLR
RT
RAASQ
S
IIP
VD
T
KL
A
AG
I
T
R
F
F
P
QF
N
DRF
E
A
I
A
V
RVPT
I
NV
TA
I
DL
S
V
T
V
K
K
P
V
K
A
N
EVN
L
L
L
Q
K
AA
Q
G
AFH
G
IV
D
YTE
LP
LVS
V
DFN
H
DPHS
AIV
D
G
TQ
-
--
T
R
V
S
G
AH
L
I
KT
L
V
W
C
DNE
W
GF
A
NRMLD
fig|585034.5.peg.2987
Escherichia coli IAI1 (1-328/339)
MTV
R
V
A
INGFGRIGR
N
V
V
R
A
L
Y
E
SG
R
R
A
EI
T
VVAIN
E
L
A
DA
AG
MA
H
LLKYD
T
SHGRF
A
W
E
V
RQER
D
Q
L
F
V
G
DD
A
IRV
L
H
ER
SLQ
S
LPW
R
E
L
GVDVV
L
D
CTG
V
Y
G
S
R
E
HG
EAHI
A
AGAKKVL
F
S
H
P
G
S
N
D
LDA
T
V
VYGVN
Q
D
Q
L
R
A
E
H
R
IVSNASCTTNC
II
PV
I
K
L
LDDA
Y
GIE
S
GT
V
TTIH
S
A
M
H
D
Q
QV
I
D
A
-
Y
H
P
DLR
RT
RAASQ
S
IIP
VD
T
KL
A
AG
I
T
R
F
F
P
QF
N
DRF
E
A
I
A
V
RVPT
I
NV
TA
I
DL
S
V
T
V
K
K
P
V
K
A
N
EVN
L
L
L
Q
K
AA
Q
G
AFH
G
IV
D
YTE
LP
LVS
V
DFN
H
DPHS
AIV
D
G
TQ
-
--
T
R
V
S
G
AH
L
I
KT
L
V
W
C
DNE
W
GF
A
NRMLD
fig|83333.1.peg.2878
Escherichia coli K12 (1-328/339)
MTV
R
V
A
INGFGRIGR
N
V
V
R
A
L
Y
E
SG
R
R
A
EI
T
VVAIN
E
L
A
DA
AG
MA
H
LLKYD
T
SHGRF
A
W
E
V
RQER
D
Q
L
F
V
G
DD
A
IRV
L
H
ER
SLQ
S
LPW
R
E
L
GVDVV
L
D
CTG
V
Y
G
S
R
E
HG
EAHI
A
AGAKKVL
F
S
H
P
G
S
N
D
LDA
T
V
VYGVN
Q
D
Q
L
R
A
E
H
R
IVSNASCTTNC
II
PV
I
K
L
LDDA
Y
GIE
S
GT
V
TTIH
S
A
M
H
D
Q
QV
I
D
A
-
Y
H
P
DLR
RT
RAASQ
S
IIP
VD
T
KL
A
AG
I
T
R
F
F
P
QF
N
DRF
E
A
I
A
V
RVPT
I
NV
TA
I
DL
S
V
T
V
K
K
P
V
K
A
N
EVN
L
L
L
Q
K
AA
Q
G
AFH
G
IV
D
YTE
LP
LVS
V
DFN
H
DPHS
AIV
D
G
TQ
-
--
T
R
V
S
G
AH
L
I
KT
L
V
W
C
DNE
W
GF
A
NRMLD
fig|595495.4.peg.1289
Escherichia coli KO11 (1-328/339)
MTV
R
V
A
INGFGRIGR
N
V
V
R
A
L
Y
E
SG
R
R
A
EI
T
VVAIN
E
L
A
DA
AG
MA
H
LLKYD
T
SHGRF
A
W
E
V
RQER
D
Q
L
F
V
G
DD
A
IRV
L
H
ER
SLQ
S
LPW
R
E
L
GVDVV
L
D
CTG
V
Y
G
S
R
E
HG
EAHI
A
AGAKKVL
F
S
H
P
G
S
N
D
LDA
T
V
VYGVN
Q
D
Q
L
R
A
E
H
R
IVSNASCTTNC
II
PV
I
K
L
LDDA
Y
GIE
S
GT
V
TTIH
S
A
M
H
D
Q
QV
I
D
A
-
Y
H
P
DLR
RT
RAASQ
S
IIP
VD
T
KL
A
AG
I
T
R
F
F
P
QF
N
DRF
E
A
I
A
V
RVPT
I
NV
TA
I
DL
S
V
T
V
K
K
P
V
K
A
N
EVN
L
L
L
Q
K
AA
Q
G
AFH
G
IV
D
YTE
LP
LVS
V
DFN
H
DPHS
AIV
D
G
TQ
-
--
T
R
V
S
G
AH
L
I
KT
L
V
W
C
DNE
W
GF
A
NRMLD
fig|656417.3.peg.3701
Escherichia coli M605 (1-328/339)
MTV
R
V
A
INGFGRIGR
N
V
V
R
A
L
Y
E
SG
R
R
A
EI
T
VVAIN
E
L
A
DA
AG
MA
H
LLKYD
T
SHGRF
A
W
E
V
RQER
D
Q
L
F
V
G
DD
A
IRV
L
H
ER
SLQ
S
LPW
R
E
L
GVDVV
L
D
CTG
V
Y
G
S
R
E
HG
EAHI
A
AGAKKVL
F
S
H
P
G
S
N
D
LDA
T
V
VYGVN
Q
D
Q
L
R
A
E
H
R
IVSNASCTTNC
II
PV
I
K
L
LDDA
Y
GIE
S
GT
V
TTIH
S
A
M
H
D
Q
QV
I
D
A
-
Y
H
P
DLR
RT
RAASQ
S
IIP
VD
T
KL
A
AG
I
T
R
F
F
P
QF
N
DRF
E
A
I
A
V
RVPT
I
NV
TA
I
DL
S
V
T
V
K
K
P
V
K
A
N
EVN
L
L
L
Q
K
AA
Q
G
AFH
G
IV
D
YTE
LP
LVS
V
DFN
H
DPHS
AIV
D
G
TQ
-
--
T
R
V
S
G
AH
L
I
KT
L
V
W
C
DNE
W
GF
A
NRMLD
fig|656419.3.peg.3782
Escherichia coli M718 (1-328/339)
MTV
R
V
A
INGFGRIGR
N
V
V
R
A
L
Y
E
SG
R
R
A
EI
T
VVAIN
E
L
A
DA
AG
MA
H
LLKYD
T
SHGRF
A
W
E
V
RQER
D
Q
L
F
V
G
DD
A
IRV
L
H
ER
SLQ
S
LPW
R
E
L
GVDVV
L
D
CTG
V
Y
G
S
R
E
HG
EAHI
A
AGAKKVL
F
S
H
P
G
S
N
D
LDA
T
V
VYGVN
Q
D
Q
L
R
A
E
H
R
IVSNASCTTNC
II
PV
I
K
L
LDDA
Y
GIE
S
GT
V
TTIH
S
A
M
H
D
Q
QV
I
D
A
-
Y
H
P
DLR
RT
RAASQ
S
IIP
VD
T
KL
A
AG
I
T
R
F
F
P
QF
N
DRF
E
A
I
A
V
RVPT
I
NV
TA
I
DL
S
V
T
V
K
K
P
V
K
A
N
EVN
L
L
L
Q
K
AA
Q
G
AFH
G
IV
D
YTE
LP
LVS
V
DFN
H
DPHS
AIV
D
G
TQ
-
--
T
R
V
S
G
AH
L
I
KT
L
V
W
C
DNE
W
GF
A
NRMLD
fig|679207.4.peg.632
Escherichia coli MS 107-1 (1-328/339)
MTV
R
V
A
INGFGRIGR
N
V
V
R
A
L
Y
E
SG
R
R
A
EI
T
VVAIN
E
L
A
DA
AG
MA
H
LLKYD
T
SHGRF
A
W
E
V
RQER
D
Q
L
F
V
G
DD
A
IRV
L
H
ER
SLQ
S
LPW
R
E
L
GVDVV
L
D
CTG
V
Y
G
S
R
E
HG
EAHI
A
AGAKKVL
F
S
H
P
G
S
N
D
LDA
T
V
VYGVN
Q
D
Q
L
R
A
E
H
R
IVSNASCTTNC
II
PV
I
K
L
LDDA
Y
GIE
S
GT
V
TTIH
S
A
M
H
D
Q
QV
I
D
A
-
Y
H
P
DLR
RT
RAASQ
S
IIP
VD
T
KL
A
AG
I
T
R
F
F
P
QF
N
DRF
E
A
I
A
V
RVPT
I
NV
TA
I
DL
S
V
T
V
K
K
P
V
K
A
N
EVN
L
L
L
Q
K
AA
Q
G
AFH
G
IV
D
YTE
LP
LVS
V
DFN
H
DPHS
AIV
D
G
TQ
-
--
T
R
V
S
G
AH
L
I
KT
L
V
W
C
DNE
W
GF
A
NRMLD
fig|749537.3.peg.4647
Escherichia coli MS 115-1 (1-328/339)
MTV
R
V
A
INGFGRIGR
N
V
V
R
A
L
Y
E
SG
R
R
A
EI
T
VVAIN
E
L
A
DA
AG
MA
H
LLKYD
T
SHGRF
A
W
E
V
RQER
D
Q
L
F
V
G
DD
A
IRV
L
H
ER
SLQ
S
LPW
R
E
L
GVDVV
L
D
CTG
V
Y
G
S
R
E
HG
EAHI
A
AGAKKVL
F
S
H
P
G
S
N
D
LDA
T
V
VYGVN
Q
D
Q
L
R
A
E
H
R
IVSNASCTTNC
II
PV
I
K
L
LDDA
Y
GIE
S
GT
V
TTIH
S
A
M
H
D
Q
QV
I
D
A
-
Y
H
P
DLR
RT
RAASQ
S
IIP
VD
T
KL
A
AG
I
T
R
F
F
P
QF
N
DRF
E
A
I
A
V
RVPT
I
NV
TA
I
DL
S
V
T
V
K
K
P
V
K
A
N
EVN
L
L
L
Q
K
AA
Q
G
AFH
G
IV
D
YTE
LP
LVS
V
DFN
H
DPHS
AIV
D
G
TQ
-
--
T
R
V
S
G
AH
L
I
KT
L
V
W
C
DNE
W
GF
A
NRMLD
fig|749538.3.peg.1186
Escherichia coli MS 116-1 (1-328/339)
MTV
R
V
A
INGFGRIGR
N
V
V
R
A
L
Y
E
SG
R
R
A
EI
T
VVAIN
E
L
A
DA
AG
MA
H
LLKYD
T
SHGRF
A
W
E
V
RQER
D
Q
L
F
V
G
DD
A
IRV
L
H
ER
SLQ
S
LPW
R
E
L
GVDVV
L
D
CTG
V
Y
G
S
R
E
HG
EAHI
A
AGAKKVL
F
S
H
P
G
S
N
D
LDA
T
V
VYGVN
Q
D
Q
L
R
A
E
H
R
IVSNASCTTNC
II
PV
I
K
L
LDDA
Y
GIE
S
GT
V
TTIH
S
A
M
H
D
Q
QV
I
D
A
-
Y
H
P
DLR
RT
RAASQ
S
IIP
VD
T
KL
A
AG
I
T
R
F
F
P
QF
N
DRF
E
A
I
A
V
RVPT
I
NV
TA
I
DL
S
V
T
V
K
K
P
V
K
A
N
EVN
L
L
L
Q
K
AA
Q
G
AFH
G
IV
D
YTE
LP
LVS
V
DFN
H
DPHS
AIV
D
G
TQ
-
--
T
R
V
S
G
AH
L
I
KT
L
V
W
C
DNE
W
GF
A
NRMLD
fig|679206.4.peg.4550
Escherichia coli MS 119-7 (1-328/339)
MTV
R
V
A
INGFGRIGR
N
V
V
R
A
L
Y
E
SG
R
R
A
EI
T
VVAIN
E
L
A
DA
AG
MA
H
LLKYD
T
SHGRF
A
W
E
V
RQER
D
Q
L
F
V
G
DD
A
IRV
L
H
ER
SLQ
S
LPW
R
E
L
GVDVV
L
D
CTG
V
Y
G
S
R
E
HG
EAHI
A
AGAKKVL
F
S
H
P
G
S
N
D
LDA
T
V
VYGVN
Q
D
Q
L
R
A
E
H
R
IVSNASCTTNC
II
PV
I
K
L
LDDA
Y
GIE
S
GT
V
TTIH
S
A
M
H
D
Q
QV
I
D
A
-
Y
H
P
DLR
RT
RAASQ
S
IIP
VD
T
KL
A
AG
I
T
R
F
F
P
QF
N
DRF
E
A
I
A
V
RVPT
I
NV
TA
I
DL
S
V
T
V
K
K
P
V
K
A
N
EVN
L
L
L
Q
K
AA
Q
G
AFH
G
IV
D
YTE
LP
LVS
V
DFN
H
DPHS
AIV
D
G
TQ
-
--
T
R
V
S
G
AH
L
I
KT
L
V
W
C
DNE
W
GF
A
NRMLD
fig|679205.4.peg.5461
Escherichia coli MS 124-1 (1-328/339)
MTV
R
V
A
INGFGRIGR
N
V
V
R
A
L
Y
E
SG
R
R
A
EI
T
VVAIN
E
L
A
DA
AG
MA
H
LLKYD
T
SHGRF
A
W
E
V
RQER
D
Q
L
F
V
G
DD
A
IRV
L
H
ER
SLQ
S
LPW
R
E
L
GVDVV
L
D
CTG
V
Y
G
S
R
E
HG
EAHI
A
AGAKKVL
F
S
H
P
G
S
N
D
LDA
T
V
VYGVN
Q
D
Q
L
R
A
E
H
R
IVSNASCTTNC
II
PV
I
K
L
LDDA
Y
GIE
S
GT
V
TTIH
S
A
M
H
D
Q
QV
I
D
A
-
Y
H
P
DLR
RT
RAASQ
S
IIP
VD
T
KL
A
AG
I
T
R
F
F
P
QF
N
DRF
E
A
I
A
V
RVPT
I
NV
TA
I
DL
S
V
T
V
K
K
P
V
K
A
N
EVN
L
L
L
Q
K
AA
Q
G
AFH
G
IV
D
YTE
LP
LVS
V
DFN
H
DPHS
AIV
D
G
TQ
-
--
T
R
V
S
G
AH
L
I
KT
L
V
W
C
DNE
W
GF
A
NRMLD
fig|679204.3.peg.1155
Escherichia coli MS 145-7 (1-328/339)
MTV
R
V
A
INGFGRIGR
N
V
V
R
A
L
Y
E
SG
R
R
A
EI
T
VVAIN
E
L
A
DA
AG
MA
H
LLKYD
T
SHGRF
A
W
E
V
RQER
D
Q
L
F
V
G
DD
A
IRV
L
H
ER
SLQ
S
LPW
R
E
L
GVDVV
L
D
CTG
V
Y
G
S
R
E
HG
EAHI
A
AGAKKVL
F
S
H
P
G
S
N
D
LDA
T
V
VYGVN
Q
D
Q
L
R
A
E
H
R
IVSNASCTTNC
II
PV
I
K
L
LDDA
Y
GIE
S
GT
V
TTIH
S
A
M
H
D
Q
QV
I
D
A
-
Y
H
P
DLR
RT
RAASQ
S
IIP
VD
T
KL
A
AG
I
T
R
F
F
P
QF
N
DRF
E
A
I
A
V
RVPT
I
NV
TA
I
DL
S
V
T
V
K
K
P
V
K
A
N
EVN
L
L
L
Q
K
AA
Q
G
AFH
G
IV
D
YTE
LP
LVS
V
DFN
H
DPHS
AIV
D
G
TQ
-
--
T
R
V
S
G
AH
L
I
KT
L
V
W
C
DNE
W
GF
A
NRMLD
fig|749544.3.peg.164
Escherichia coli MS 175-1 (1-328/339)
MTV
R
V
A
INGFGRIGR
N
V
V
R
A
L
Y
E
SG
R
R
A
EI
T
VVAIN
E
L
A
DA
AG
MA
H
LLKYD
T
SHGRF
A
W
E
V
RQER
D
Q
L
F
V
G
DD
A
IRV
L
H
ER
SLQ
S
LPW
R
E
L
GVDVV
L
D
CTG
V
Y
G
S
R
E
HG
EAHI
A
AGAKKVL
F
S
H
P
G
S
N
D
LDA
T
V
VYGVN
Q
D
Q
L
R
A
E
H
R
IVSNASCTTNC
II
PV
I
K
L
LDDA
Y
GIE
S
GT
V
TTIH
S
A
M
H
D
Q
QV
I
D
A
-
Y
H
P
DLR
RT
RAASQ
S
IIP
VD
T
KL
A
AG
I
T
R
F
F
P
QF
N
DRF
E
A
I
A
V
RVPT
I
NV
TA
I
DL
S
V
T
V
K
K
P
V
K
A
N
EVN
L
L
L
Q
K
AA
Q
G
AFH
G
IV
D
YTE
LP
LVS
V
DFN
H
DPHS
AIV
D
G
TQ
-
--
T
R
V
S
G
AH
L
I
KT
L
V
W
C
DNE
W
GF
A
NRMLD
fig|749546.3.peg.3306
Escherichia coli MS 185-1 (1-328/339)
MTV
R
V
A
INGFGRIGR
N
V
V
R
A
L
Y
E
SG
R
R
A
EI
T
VVAIN
E
L
A
DA
AG
MA
H
LLKYD
T
SHGRF
A
W
E
V
RQER
D
Q
L
F
V
G
DD
A
IRV
L
H
ER
SLQ
S
LPW
R
E
L
GVDVV
L
D
CTG
V
Y
G
S
R
E
HG
EAHI
A
AGAKKVL
F
S
H
P
G
S
N
D
LDA
T
V
VYGVN
Q
D
Q
L
R
A
E
H
R
IVSNASCTTNC
II
PV
I
K
L
LDDA
Y
GIE
S
GT
V
TTIH
S
A
M
H
D
Q
QV
I
D
A
-
Y
H
P
DLR
RT
RAASQ
S
IIP
VD
T
KL
A
AG
I
T
R
F
F
P
QF
N
DRF
E
A
I
A
V
RVPT
I
NV
TA
I
DL
S
V
T
V
K
K
P
V
K
A
N
EVN
L
L
L
Q
K
AA
Q
G
AFH
G
IV
D
YTE
LP
LVS
V
DFN
H
DPHS
AIV
D
G
TQ
-
--
T
R
V
S
G
AH
L
I
KT
L
V
W
C
DNE
W
GF
A
NRMLD
fig|749547.3.peg.486
Escherichia coli MS 187-1 (1-328/339)
MTV
R
V
A
INGFGRIGR
N
V
V
R
A
L
Y
E
SG
R
R
A
EI
T
VVAIN
E
L
A
DA
AG
MA
H
LLKYD
T
SHGRF
A
W
E
V
RQER
D
Q
L
F
V
G
DD
A
IRV
L
H
ER
SLQ
S
LPW
R
E
L
GVDVV
L
D
CTG
V
Y
G
S
R
E
HG
EAHI
A
AGAKKVL
F
S
H
P
G
S
N
D
LDA
T
V
VYGVN
Q
D
Q
L
R
A
E
H
R
IVSNASCTTNC
II
PV
I
K
L
LDDA
Y
GIE
S
GT
V
TTIH
S
A
M
H
D
Q
QV
I
D
A
-
Y
H
P
DLR
RT
RAASQ
S
IIP
VD
T
KL
A
AG
I
T
R
F
F
P
QF
N
DRF
E
A
I
A
V
RVPT
I
NV
TA
I
DL
S
V
T
V
K
K
P
V
K
A
N
EVN
L
L
L
Q
K
AA
Q
G
AFH
G
IV
D
YTE
LP
LVS
V
DFN
H
DPHS
AIV
D
G
TQ
-
--
T
R
V
S
G
AH
L
I
KT
L
V
W
C
DNE
W
GF
A
NRMLD
fig|749548.3.peg.3503
Escherichia coli MS 196-1 (1-328/339)
MTV
R
V
A
INGFGRIGR
N
V
V
R
A
L
Y
E
SG
R
R
A
EI
T
VVAIN
E
L
A
DA
AG
MA
H
LLKYD
T
SHGRF
A
W
E
V
RQER
D
Q
L
F
V
G
DD
A
IRV
L
H
ER
SLQ
S
LPW
R
E
L
GVDVV
L
D
CTG
V
Y
G
S
R
E
HG
EAHI
A
AGAKKVL
F
S
H
P
G
S
N
D
LDA
T
V
VYGVN
Q
D
Q
L
R
A
E
H
R
IVSNASCTTNC
II
PV
I
K
L
LDDA
Y
GIE
S
GT
V
TTIH
S
A
M
H
D
Q
QV
I
D
A
-
Y
H
P
DLR
RT
RAASQ
S
IIP
VD
T
KL
A
AG
I
T
R
F
F
P
QF
N
DRF
E
A
I
A
V
RVPT
I
NV
TA
I
DL
S
V
T
V
K
K
P
V
K
A
N
EVN
L
L
L
Q
K
AA
Q
G
AFH
G
IV
D
YTE
LP
LVS
V
DFN
H
DPHS
AIV
D
G
TQ
-
--
T
R
V
S
G
AH
L
I
KT
L
V
W
C
DNE
W
GF
A
NRMLD
fig|749549.3.peg.486
Escherichia coli MS 198-1 (1-328/339)
MTV
R
V
A
INGFGRIGR
N
V
V
R
A
L
Y
E
SG
R
R
A
EI
T
VVAIN
E
L
A
DA
AG
MA
H
LLKYD
T
SHGRF
A
W
E
V
RQER
D
Q
L
F
V
G
DD
A
IRV
L
H
ER
SLQ
S
LPW
R
E
L
GVDVV
L
D
CTG
V
Y
G
S
R
E
HG
EAHI
A
AGAKKVL
F
S
H
P
G
S
N
D
LDA
T
V
VYGVN
Q
D
Q
L
R
A
E
H
R
IVSNASCTTNC
II
PV
I
K
L
LDDA
Y
GIE
S
GT
V
TTIH
S
A
M
H
D
Q
QV
I
D
A
-
Y
H
P
DLR
RT
RAASQ
S
IIP
VD
T
KL
A
AG
I
T
R
F
F
P
QF
N
DRF
E
A
I
A
V
RVPT
I
NV
TA
I
DL
S
V
T
V
K
K
P
V
K
A
N
EVN
L
L
L
Q
K
AA
Q
G
AFH
G
IV
D
YTE
LP
LVS
V
DFN
H
DPHS
AIV
D
G
TQ
-
--
T
R
V
S
G
AH
L
I
KT
L
V
W
C
DNE
W
GF
A
NRMLD
fig|749550.3.peg.4292
Escherichia coli MS 200-1 (1-328/339)
MTV
R
V
A
INGFGRIGR
N
V
V
R
A
L
Y
E
SG
R
R
A
EI
T
VVAIN
E
L
A
DA
AG
MA
H
LLKYD
T
SHGRF
A
W
E
V
RQER
D
Q
L
F
V
G
DD
A
IRV
L
H
ER
SLQ
S
LPW
R
E
L
GVDVV
L
D
CTG
V
Y
G
S
R
E
HG
EAHI
A
AGAKKVL
F
S
H
P
G
S
N
D
LDA
T
V
VYGVN
Q
D
Q
L
R
A
E
H
R
IVSNASCTTNC
II
PV
I
K
L
LDDA
Y
GIE
S
GT
V
TTIH
S
A
M
H
D
Q
QV
I
D
A
-
Y
H
P
DLR
RT
RAASQ
S
IIP
VD
T
KL
A
AG
I
T
R
F
F
P
QF
N
DRF
E
A
I
A
V
RVPT
I
NV
TA
I
DL
S
V
T
V
K
K
P
V
K
A
N
EVN
L
L
L
Q
K
AA
Q
G
AFH
G
IV
D
YTE
LP
LVS
V
DFN
H
DPHS
AIV
D
G
TQ
-
--
T
R
V
S
G
AH
L
I
KT
L
V
W
C
DNE
W
GF
A
NRMLD
fig|749527.3.peg.951
Escherichia coli MS 21-1 (1-328/339)
MTV
R
V
A
INGFGRIGR
N
V
V
R
A
L
Y
E
SG
R
R
A
EI
T
VVAIN
E
L
A
DA
AG
MA
H
LLKYD
T
SHGRF
A
W
E
V
RQER
D
Q
L
F
V
G
DD
A
IRV
L
H
ER
SLQ
S
LPW
R
E
L
GVDVV
L
D
CTG
V
Y
G
S
R
E
HG
EAHI
A
AGAKKVL
F
S
H
P
G
S
N
D
LDA
T
V
VYGVN
Q
D
Q
L
R
A
E
H
R
IVSNASCTTNC
II
PV
I
K
L
LDDA
Y
GIE
S
GT
V
TTIH
S
A
M
H
D
Q
QV
I
D
A
-
Y
H
P
DLR
RT
RAASQ
S
IIP
VD
T
KL
A
AG
I
T
R
F
F
P
QF
N
DRF
E
A
I
A
V
RVPT
I
NV
TA
I
DL
S
V
T
V
K
K
P
V
K
A
N
EVN
L
L
L
Q
K
AA
Q
G
AFH
G
IV
D
YTE
LP
LVS
V
DFN
H
DPHS
AIV
D
G
TQ
-
--
T
R
V
S
G
AH
L
I
KT
L
V
W
C
DNE
W
GF
A
NRMLD
fig|749528.3.peg.1930
Escherichia coli MS 45-1 (1-328/339)
MTV
R
V
A
INGFGRIGR
N
V
V
R
A
L
Y
E
SG
R
R
A
EI
T
VVAIN
E
L
A
DA
AG
MA
H
LLKYD
T
SHGRF
A
W
E
V
RQER
D
Q
L
F
V
G
DD
A
IRV
L
H
ER
SLQ
S
LPW
R
E
L
GVDVV
L
D
CTG
V
Y
G
S
R
E
HG
EAHI
A
AGAKKVL
F
S
H
P
G
S
N
D
LDA
T
V
VYGVN
Q
D
Q
L
R
A
E
H
R
IVSNASCTTNC
II
PV
I
K
L
LDDA
Y
GIE
S
GT
V
TTIH
S
A
M
H
D
Q
QV
I
D
A
-
Y
H
P
DLR
RT
RAASQ
S
IIP
VD
T
KL
A
AG
I
T
R
F
F
P
QF
N
DRF
E
A
I
A
V
RVPT
I
NV
TA
I
DL
S
V
T
V
K
K
P
V
K
A
N
EVN
L
L
L
Q
K
AA
Q
G
AFH
G
IV
D
YTE
LP
LVS
V
DFN
H
DPHS
AIV
D
G
TQ
-
--
T
R
V
S
G
AH
L
I
KT
L
V
W
C
DNE
W
GF
A
NRMLD
fig|749531.3.peg.5086
Escherichia coli MS 69-1 (1-328/339)
MTV
R
V
A
INGFGRIGR
N
V
V
R
A
L
Y
E
SG
R
R
A
EI
T
VVAIN
E
L
A
DA
AG
MA
H
LLKYD
T
SHGRF
A
W
E
V
RQER
D
Q
L
F
V
G
DD
A
IRV
L
H
ER
SLQ
S
LPW
R
E
L
GVDVV
L
D
CTG
V
Y
G
S
R
E
HG
EAHI
A
AGAKKVL
F
S
H
P
G
S
N
D
LDA
T
V
VYGVN
Q
D
Q
L
R
A
E
H
R
IVSNASCTTNC
II
PV
I
K
L
LDDA
Y
GIE
S
GT
V
TTIH
S
A
M
H
D
Q
QV
I
D
A
-
Y
H
P
DLR
RT
RAASQ
S
IIP
VD
T
KL
A
AG
I
T
R
F
F
P
QF
N
DRF
E
A
I
A
V
RVPT
I
NV
TA
I
DL
S
V
T
V
K
K
P
V
K
A
N
EVN
L
L
L
Q
K
AA
Q
G
AFH
G
IV
D
YTE
LP
LVS
V
DFN
H
DPHS
AIV
D
G
TQ
-
--
T
R
V
S
G
AH
L
I
KT
L
V
W
C
DNE
W
GF
A
NRMLD
fig|749532.3.peg.2109
Escherichia coli MS 78-1 (1-328/339)
MTV
R
V
A
INGFGRIGR
N
V
V
R
A
L
Y
E
SG
R
R
A
EI
T
VVAIN
E
L
A
DA
AG
MA
H
LLKYD
T
SHGRF
A
W
E
V
RQER
D
Q
L
F
V
G
DD
A
IRV
L
H
ER
SLQ
S
LPW
R
E
L
GVDVV
L
D
CTG
V
Y
G
S
R
E
HG
EAHI
A
AGAKKVL
F
S
H
P
G
S
N
D
LDA
T
V
VYGVN
Q
D
Q
L
R
A
E
H
R
IVSNASCTTNC
II
PV
I
K
L
LDDA
Y
GIE
S
GT
V
TTIH
S
A
M
H
D
Q
QV
I
D
A
-
Y
H
P
DLR
RT
RAASQ
S
IIP
VD
T
KL
A
AG
I
T
R
F
F
P
QF
N
DRF
E
A
I
A
V
RVPT
I
NV
TA
I
DL
S
V
T
V
K
K
P
V
K
A
N
EVN
L
L
L
Q
K
AA
Q
G
AFH
G
IV
D
YTE
LP
LVS
V
DFN
H
DPHS
AIV
D
G
TQ
-
--
T
R
V
S
G
AH
L
I
KT
L
V
W
C
DNE
W
GF
A
NRMLD
fig|749533.3.peg.4453
Escherichia coli MS 84-1 (1-328/339)
MTV
R
V
A
INGFGRIGR
N
V
V
R
A
L
Y
E
SG
R
R
A
EI
T
VVAIN
E
L
A
DA
AG
MA
H
LLKYD
T
SHGRF
A
W
E
V
RQER
D
Q
L
F
V
G
DD
A
IRV
L
H
ER
SLQ
S
LPW
R
E
L
GVDVV
L
D
CTG
V
Y
G
S
R
E
HG
EAHI
A
AGAKKVL
F
S
H
P
G
S
N
D
LDA
T
V
VYGVN
Q
D
Q
L
R
A
E
H
R
IVSNASCTTNC
II
PV
I
K
L
LDDA
Y
GIE
S
GT
V
TTIH
S
A
M
H
D
Q
QV
I
D
A
-
Y
H
P
DLR
RT
RAASQ
S
IIP
VD
T
KL
A
AG
I
T
R
F
F
P
QF
N
DRF
E
A
I
A
V
RVPT
I
NV
TA
I
DL
S
V
T
V
K
K
P
V
K
A
N
EVN
L
L
L
Q
K
AA
Q
G
AFH
G
IV
D
YTE
LP
LVS
V
DFN
H
DPHS
AIV
D
G
TQ
-
--
T
R
V
S
G
AH
L
I
KT
L
V
W
C
DNE
W
GF
A
NRMLD
fig|753642.3.peg.196
Escherichia coli NC101 (1-328/339)
MTV
R
V
A
INGFGRIGR
N
V
V
R
A
L
Y
E
SG
R
R
A
EI
T
VVAIN
E
L
A
DA
AG
MA
H
LLKYD
T
SHGRF
A
W
E
V
RQER
D
Q
L
F
V
G
DD
A
IRV
L
H
ER
SLQ
S
LPW
R
E
L
GVDVV
L
D
CTG
V
Y
G
S
R
E
HG
EAHI
A
AGAKKVL
F
S
H
P
G
S
N
D
LDA
T
V
VYGVN
Q
D
Q
L
R
A
E
H
R
IVSNASCTTNC
II
PV
I
K
L
LDDA
Y
GIE
S
GT
V
TTIH
S
A
M
H
D
Q
QV
I
D
A
-
Y
H
P
DLR
RT
RAASQ
S
IIP
VD
T
KL
A
AG
I
T
R
F
F
P
QF
N
DRF
E
A
I
A
V
RVPT
I
NV
TA
I
DL
S
V
T
V
K
K
P
V
K
A
N
EVN
L
L
L
Q
K
AA
Q
G
AFH
G
IV
D
YTE
LP
LVS
V
DFN
H
DPHS
AIV
D
G
TQ
-
--
T
R
V
S
G
AH
L
I
KT
L
V
W
C
DNE
W
GF
A
NRMLD
fig|585395.4.peg.3659
Escherichia coli O103:H2 str. 12009 (1-328/339)
MTV
R
V
A
INGFGRIGR
N
V
V
R
A
L
Y
E
SG
R
R
A
EI
T
VVAIN
E
L
A
DA
AG
MA
H
LLKYD
T
SHGRF
A
W
E
V
RQER
D
Q
L
F
V
G
DD
A
IRV
L
H
ER
SLQ
S
LPW
R
E
L
GVDVV
L
D
CTG
V
Y
G
S
R
E
HG
EAHI
A
AGAKKVL
F
S
H
P
G
S
N
D
LDA
T
V
VYGVN
Q
D
Q
L
R
A
E
H
R
IVSNASCTTNC
II
PV
I
K
L
LDDA
Y
GIE
S
GT
V
TTIH
S
A
M
H
D
Q
QV
I
D
A
-
Y
H
P
DLR
RT
RAASQ
S
IIP
VD
T
KL
A
AG
I
T
R
F
F
P
QF
N
DRF
E
A
I
A
V
RVPT
I
NV
TA
I
DL
S
V
T
V
K
K
P
V
K
A
N
EVN
L
L
L
Q
K
AA
Q
G
AFH
G
IV
D
YTE
LP
LVS
V
DFN
H
DPHS
AIV
D
G
TQ
-
--
T
R
V
S
G
AH
L
I
KT
L
V
W
C
DNE
W
GF
A
NRMLD
fig|585396.4.peg.3789
Escherichia coli O111:H- str. 11128 (1-328/339)
MTV
R
V
A
INGFGRIGR
N
V
V
R
A
L
Y
E
SG
R
R
A
EI
T
VVAIN
E
L
A
DA
AG
MA
H
LLKYD
T
SHGRF
A
W
E
V
RQER
D
Q
L
F
V
G
DD
A
IRV
L
H
ER
SLQ
S
LPW
R
E
L
GVDVV
L
D
CTG
V
Y
G
S
R
E
HG
EAHI
A
AGAKKVL
F
S
H
P
G
S
N
D
LDA
T
V
VYGVN
Q
D
Q
L
R
A
E
H
R
IVSNASCTTNC
II
PV
I
K
L
LDDA
Y
GIE
S
GT
V
TTIH
S
A
M
H
D
Q
QV
I
D
A
-
Y
H
P
DLR
RT
RAASQ
S
IIP
VD
T
KL
A
AG
I
T
R
F
F
P
QF
N
DRF
E
A
I
A
V
RVPT
I
NV
TA
I
DL
S
V
T
V
K
K
P
V
K
A
N
EVN
L
L
L
Q
K
AA
Q
G
AFH
G
IV
D
YTE
LP
LVS
V
DFN
H
DPHS
AIV
D
G
TQ
-
--
T
R
V
S
G
AH
L
I
KT
L
V
W
C
DNE
W
GF
A
NRMLD
fig|83334.1.peg.3782
Escherichia coli O157:H7 (1-328/339)
MTV
R
V
A
INGFGRIGR
N
V
V
R
A
L
Y
E
SG
R
R
A
EI
T
VVAIN
E
L
A
DA
AG
MA
H
LLKYD
T
SHGRF
A
W
E
V
RQER
D
Q
L
F
V
G
DD
A
IRV
L
H
ER
SLQ
S
LPW
R
E
L
GVDVV
L
D
CTG
V
Y
G
S
R
E
HG
EAHI
A
AGAKKVL
F
S
H
P
G
S
N
D
LDA
T
V
VYGVN
Q
D
Q
L
R
A
E
H
R
IVSNASCTTNC
II
PV
I
K
L
LDDA
Y
GIE
S
GT
V
TTIH
S
A
M
H
D
Q
QV
I
D
A
-
Y
H
P
DLR
RT
RAASQ
S
IIP
VD
T
KL
A
AG
I
T
R
F
F
P
QF
N
DRF
E
A
I
A
V
RVPT
I
NV
TA
I
DL
S
V
T
V
K
K
P
V
K
A
N
EVN
L
L
L
Q
K
AA
Q
G
AFH
G
IV
D
YTE
LP
LVS
V
DFN
H
DPHS
AIV
D
G
TQ
-
--
T
R
V
S
G
AH
L
I
KT
L
V
W
C
DNE
W
GF
A
NRMLD
fig|155864.1.peg.3802
Escherichia coli O157:H7 EDL933 (1-328/339)
MTV
R
V
A
INGFGRIGR
N
V
V
R
A
L
Y
E
SG
R
R
A
EI
T
VVAIN
E
L
A
DA
AG
MA
H
LLKYD
T
SHGRF
A
W
E
V
RQER
D
Q
L
F
V
G
DD
A
IRV
L
H
ER
SLQ
S
LPW
R
E
L
GVDVV
L
D
CTG
V
Y
G
S
R
E
HG
EAHI
A
AGAKKVL
F
S
H
P
G
S
N
D
LDA
T
V
VYGVN
Q
D
Q
L
R
A
E
H
R
IVSNASCTTNC
II
PV
I
K
L
LDDA
Y
GIE
S
GT
V
TTIH
S
A
M
H
D
Q
QV
I
D
A
-
Y
H
P
DLR
RT
RAASQ
S
IIP
VD
T
KL
A
AG
I
T
R
F
F
P
QF
N
DRF
E
A
I
A
V
RVPT
I
NV
TA
I
DL
S
V
T
V
K
K
P
V
K
A
N
EVN
L
L
L
Q
K
AA
Q
G
AFH
G
IV
D
YTE
LP
LVS
V
DFN
H
DPHS
AIV
D
G
TQ
-
--
T
R
V
S
G
AH
L
I
KT
L
V
W
C
DNE
W
GF
A
NRMLD
fig|155864.8.peg.3721
Escherichia coli O157:H7 EDL933 (1-328/339)
MTV
R
V
A
INGFGRIGR
N
V
V
R
A
L
Y
E
SG
R
R
A
EI
T
VVAIN
E
L
A
DA
AG
MA
H
LLKYD
T
SHGRF
A
W
E
V
RQER
D
Q
L
F
V
G
DD
A
IRV
L
H
ER
SLQ
S
LPW
R
E
L
GVDVV
L
D
CTG
V
Y
G
S
R
E
HG
EAHI
A
AGAKKVL
F
S
H
P
G
S
N
D
LDA
T
V
VYGVN
Q
D
Q
L
R
A
E
H
R
IVSNASCTTNC
II
PV
I
K
L
LDDA
Y
GIE
S
GT
V
TTIH
S
A
M
H
D
Q
QV
I
D
A
-
Y
H
P
DLR
RT
RAASQ
S
IIP
VD
T
KL
A
AG
I
T
R
F
F
P
QF
N
DRF
E
A
I
A
V
RVPT
I
NV
TA
I
DL
S
V
T
V
K
K
P
V
K
A
N
EVN
L
L
L
Q
K
AA
Q
G
AFH
G
IV
D
YTE
LP
LVS
V
DFN
H
DPHS
AIV
D
G
TQ
-
--
T
R
V
S
G
AH
L
I
KT
L
V
W
C
DNE
W
GF
A
NRMLD
fig|444454.5.peg.2846
Escherichia coli O157:H7 str. EC4024 (1-328/339)
MTV
R
V
A
INGFGRIGR
N
V
V
R
A
L
Y
E
SG
R
R
A
EI
T
VVAIN
E
L
A
DA
AG
MA
H
LLKYD
T
SHGRF
A
W
E
V
RQER
D
Q
L
F
V
G
DD
A
IRV
L
H
ER
SLQ
S
LPW
R
E
L
GVDVV
L
D
CTG
V
Y
G
S
R
E
HG
EAHI
A
AGAKKVL
F
S
H
P
G
S
N
D
LDA
T
V
VYGVN
Q
D
Q
L
R
A
E
H
R
IVSNASCTTNC
II
PV
I
K
L
LDDA
Y
GIE
S
GT
V
TTIH
S
A
M
H
D
Q
QV
I
D
A
-
Y
H
P
DLR
RT
RAASQ
S
IIP
VD
T
KL
A
AG
I
T
R
F
F
P
QF
N
DRF
E
A
I
A
V
RVPT
I
NV
TA
I
DL
S
V
T
V
K
K
P
V
K
A
N
EVN
L
L
L
Q
K
AA
Q
G
AFH
G
IV
D
YTE
LP
LVS
V
DFN
H
DPHS
AIV
D
G
TQ
-
--
T
R
V
S
G
AH
L
I
KT
L
V
W
C
DNE
W
GF
A
NRMLD
fig|444449.5.peg.2301
Escherichia coli O157:H7 str. EC4042 (1-328/339)
MTV
R
V
A
INGFGRIGR
N
V
V
R
A
L
Y
E
SG
R
R
A
EI
T
VVAIN
E
L
A
DA
AG
MA
H
LLKYD
T
SHGRF
A
W
E
V
RQER
D
Q
L
F
V
G
DD
A
IRV
L
H
ER
SLQ
S
LPW
R
E
L
GVDVV
L
D
CTG
V
Y
G
S
R
E
HG
EAHI
A
AGAKKVL
F
S
H
P
G
S
N
D
LDA
T
V
VYGVN
Q
D
Q
L
R
A
E
H
R
IVSNASCTTNC
II
PV
I
K
L
LDDA
Y
GIE
S
GT
V
TTIH
S
A
M
H
D
Q
QV
I
D
A
-
Y
H
P
DLR
RT
RAASQ
S
IIP
VD
T
KL
A
AG
I
T
R
F
F
P
QF
N
DRF
E
A
I
A
V
RVPT
I
NV
TA
I
DL
S
V
T
V
K
K
P
V
K
A
N
EVN
L
L
L
Q
K
AA
Q
G
AFH
G
IV
D
YTE
LP
LVS
V
DFN
H
DPHS
AIV
D
G
TQ
-
--
T
R
V
S
G
AH
L
I
KT
L
V
W
C
DNE
W
GF
A
NRMLD
fig|444448.5.peg.1056
Escherichia coli O157:H7 str. EC4045 (1-328/339)
MTV
R
V
A
INGFGRIGR
N
V
V
R
A
L
Y
E
SG
R
R
A
EI
T
VVAIN
E
L
A
DA
AG
MA
H
LLKYD
T
SHGRF
A
W
E
V
RQER
D
Q
L
F
V
G
DD
A
IRV
L
H
ER
SLQ
S
LPW
R
E
L
GVDVV
L
D
CTG
V
Y
G
S
R
E
HG
EAHI
A
AGAKKVL
F
S
H
P
G
S
N
D
LDA
T
V
VYGVN
Q
D
Q
L
R
A
E
H
R
IVSNASCTTNC
II
PV
I
K
L
LDDA
Y
GIE
S
GT
V
TTIH
S
A
M
H
D
Q
QV
I
D
A
-
Y
H
P
DLR
RT
RAASQ
S
IIP
VD
T
KL
A
AG
I
T
R
F
F
P
QF
N
DRF
E
A
I
A
V
RVPT
I
NV
TA
I
DL
S
V
T
V
K
K
P
V
K
A
N
EVN
L
L
L
Q
K
AA
Q
G
AFH
G
IV
D
YTE
LP
LVS
V
DFN
H
DPHS
AIV
D
G
TQ
-
--
T
R
V
S
G
AH
L
I
KT
L
V
W
C
DNE
W
GF
A
NRMLD
fig|444453.5.peg.3184
Escherichia coli O157:H7 str. EC4076 (1-328/339)
MTV
R
V
A
INGFGRIGR
N
V
V
R
A
L
Y
E
SG
R
R
A
EI
T
VVAIN
E
L
A
DA
AG
MA
H
LLKYD
T
SHGRF
A
W
E
V
RQER
D
Q
L
F
V
G
DD
A
IRV
L
H
ER
SLQ
S
LPW
R
E
L
GVDVV
L
D
CTG
V
Y
G
S
R
E
HG
EAHI
A
AGAKKVL
F
S
H
P
G
S
N
D
LDA
T
V
VYGVN
Q
D
Q
L
R
A
E
H
R
IVSNASCTTNC
II
PV
I
K
L
LDDA
Y
GIE
S
GT
V
TTIH
S
A
M
H
D
Q
QV
I
D
A
-
Y
H
P
DLR
RT
RAASQ
S
IIP
VD
T
KL
A
AG
I
T
R
F
F
P
QF
N
DRF
E
A
I
A
V
RVPT
I
NV
TA
I
DL
S
V
T
V
K
K
P
V
K
A
N
EVN
L
L
L
Q
K
AA
Q
G
AFH
G
IV
D
YTE
LP
LVS
V
DFN
H
DPHS
AIV
D
G
TQ
-
--
T
R
V
S
G
AH
L
I
KT
L
V
W
C
DNE
W
GF
A
NRMLD
fig|444452.5.peg.718
Escherichia coli O157:H7 str. EC4113 (1-328/339)
MTV
R
V
A
INGFGRIGR
N
V
V
R
A
L
Y
E
SG
R
R
A
EI
T
VVAIN
E
L
A
DA
AG
MA
H
LLKYD
T
SHGRF
A
W
E
V
RQER
D
Q
L
F
V
G
DD
A
IRV
L
H
ER
SLQ
S
LPW
R
E
L
GVDVV
L
D
CTG
V
Y
G
S
R
E
HG
EAHI
A
AGAKKVL
F
S
H
P
G
S
N
D
LDA
T
V
VYGVN
Q
D
Q
L
R
A
E
H
R
IVSNASCTTNC
II
PV
I
K
L
LDDA
Y
GIE
S
GT
V
TTIH
S
A
M
H
D
Q
QV
I
D
A
-
Y
H
P
DLR
RT
RAASQ
S
IIP
VD
T
KL
A
AG
I
T
R
F
F
P
QF
N
DRF
E
A
I
A
V
RVPT
I
NV
TA
I
DL
S
V
T
V
K
K
P
V
K
A
N
EVN
L
L
L
Q
K
AA
Q
G
AFH
G
IV
D
YTE
LP
LVS
V
DFN
H
DPHS
AIV
D
G
TQ
-
--
T
R
V
S
G
AH
L
I
KT
L
V
W
C
DNE
W
GF
A
NRMLD
fig|444450.8.peg.4142
Escherichia coli O157:H7 str. EC4115 (1-328/339)
MTV
R
V
A
INGFGRIGR
N
V
V
R
A
L
Y
E
SG
R
R
A
EI
T
VVAIN
E
L
A
DA
AG
MA
H
LLKYD
T
SHGRF
A
W
E
V
RQER
D
Q
L
F
V
G
DD
A
IRV
L
H
ER
SLQ
S
LPW
R
E
L
GVDVV
L
D
CTG
V
Y
G
S
R
E
HG
EAHI
A
AGAKKVL
F
S
H
P
G
S
N
D
LDA
T
V
VYGVN
Q
D
Q
L
R
A
E
H
R
IVSNASCTTNC
II
PV
I
K
L
LDDA
Y
GIE
S
GT
V
TTIH
S
A
M
H
D
Q
QV
I
D
A
-
Y
H
P
DLR
RT
RAASQ
S
IIP
VD
T
KL
A
AG
I
T
R
F
F
P
QF
N
DRF
E
A
I
A
V
RVPT
I
NV
TA
I
DL
S
V
T
V
K
K
P
V
K
A
N
EVN
L
L
L
Q
K
AA
Q
G
AFH
G
IV
D
YTE
LP
LVS
V
DFN
H
DPHS
AIV
D
G
TQ
-
--
T
R
V
S
G
AH
L
I
KT
L
V
W
C
DNE
W
GF
A
NRMLD
fig|444451.5.peg.1139
Escherichia coli O157:H7 str. EC4196 (1-328/339)
MTV
R
V
A
INGFGRIGR
N
V
V
R
A
L
Y
E
SG
R
R
A
EI
T
VVAIN
E
L
A
DA
AG
MA
H
LLKYD
T
SHGRF
A
W
E
V
RQER
D
Q
L
F
V
G
DD
A
IRV
L
H
ER
SLQ
S
LPW
R
E
L
GVDVV
L
D
CTG
V
Y
G
S
R
E
HG
EAHI
A
AGAKKVL
F
S
H
P
G
S
N
D
LDA
T
V
VYGVN
Q
D
Q
L
R
A
E
H
R
IVSNASCTTNC
II
PV
I
K
L
LDDA
Y
GIE
S
GT
V
TTIH
S
A
M
H
D
Q
QV
I
D
A
-
Y
H
P
DLR
RT
RAASQ
S
IIP
VD
T
KL
A
AG
I
T
R
F
F
P
QF
N
DRF
E
A
I
A
V
RVPT
I
NV
TA
I
DL
S
V
T
V
K
K
P
V
K
A
N
EVN
L
L
L
Q
K
AA
Q
G
AFH
G
IV
D
YTE
LP
LVS
V
DFN
H
DPHS
AIV
D
G
TQ
-
--
T
R
V
S
G
AH
L
I
KT
L
V
W
C
DNE
W
GF
A
NRMLD
fig|444447.5.peg.1212
Escherichia coli O157:H7 str. EC4206 (1-328/339)
MTV
R
V
A
INGFGRIGR
N
V
V
R
A
L
Y
E
SG
R
R
A
EI
T
VVAIN
E
L
A
DA
AG
MA
H
LLKYD
T
SHGRF
A
W
E
V
RQER
D
Q
L
F
V
G
DD
A
IRV
L
H
ER
SLQ
S
LPW
R
E
L
GVDVV
L
D
CTG
V
Y
G
S
R
E
HG
EAHI
A
AGAKKVL
F
S
H
P
G
S
N
D
LDA
T
V
VYGVN
Q
D
Q
L
R
A
E
H
R
IVSNASCTTNC
II
PV
I
K
L
LDDA
Y
GIE
S
GT
V
TTIH
S
A
M
H
D
Q
QV
I
D
A
-
Y
H
P
DLR
RT
RAASQ
S
IIP
VD
T
KL
A
AG
I
T
R
F
F
P
QF
N
DRF
E
A
I
A
V
RVPT
I
NV
TA
I
DL
S
V
T
V
K
K
P
V
K
A
N
EVN
L
L
L
Q
K
AA
Q
G
AFH
G
IV
D
YTE
LP
LVS
V
DFN
H
DPHS
AIV
D
G
TQ
-
--
T
R
V
S
G
AH
L
I
KT
L
V
W
C
DNE
W
GF
A
NRMLD
fig|478004.5.peg.743
Escherichia coli O157:H7 str. EC4401 (1-328/339)
MTV
R
V
A
INGFGRIGR
N
V
V
R
A
L
Y
E
SG
R
R
A
EI
T
VVAIN
E
L
A
DA
AG
MA
H
LLKYD
T
SHGRF
A
W
E
V
RQER
D
Q
L
F
V
G
DD
A
IRV
L
H
ER
SLQ
S
LPW
R
E
L
GVDVV
L
D
CTG
V
Y
G
S
R
E
HG
EAHI
A
AGAKKVL
F
S
H
P
G
S
N
D
LDA
T
V
VYGVN
Q
D
Q
L
R
A
E
H
R
IVSNASCTTNC
II
PV
I
K
L
LDDA
Y
GIE
S
GT
V
TTIH
S
A
M
H
D
Q
QV
I
D
A
-
Y
H
P
DLR
RT
RAASQ
S
IIP
VD
T
KL
A
AG
I
T
R
F
F
P
QF
N
DRF
E
A
I
A
V
RVPT
I
NV
TA
I
DL
S
V
T
V
K
K
P
V
K
A
N
EVN
L
L
L
Q
K
AA
Q
G
AFH
G
IV
D
YTE
LP
LVS
V
DFN
H
DPHS
AIV
D
G
TQ
-
--
T
R
V
S
G
AH
L
I
KT
L
V
W
C
DNE
W
GF
A
NRMLD
fig|478005.5.peg.1085
Escherichia coli O157:H7 str. EC4486 (1-328/339)
MTV
R
V
A
INGFGRIGR
N
V
V
R
A
L
Y
E
SG
R
R
A
EI
T
VVAIN
E
L
A
DA
AG
MA
H
LLKYD
T
SHGRF
A
W
E
V
RQER
D
Q
L
F
V
G
DD
A
IRV
L
H
ER
SLQ
S
LPW
R
E
L
GVDVV
L
D
CTG
V
Y
G
S
R
E
HG
EAHI
A
AGAKKVL
F
S
H
P
G
S
N
D
LDA
T
V
VYGVN
Q
D
Q
L
R
A
E
H
R
IVSNASCTTNC
II
PV
I
K
L
LDDA
Y
GIE
S
GT
V
TTIH
S
A
M
H
D
Q
QV
I
D
A
-
Y
H
P
DLR
RT
RAASQ
S
IIP
VD
T
KL
A
AG
I
T
R
F
F
P
QF
N
DRF
E
A
I
A
V
RVPT
I
NV
TA
I
DL
S
V
T
V
K
K
P
V
K
A
N
EVN
L
L
L
Q
K
AA
Q
G
AFH
G
IV
D
YTE
LP
LVS
V
DFN
H
DPHS
AIV
D
G
TQ
-
--
T
R
V
S
G
AH
L
I
KT
L
V
W
C
DNE
W
GF
A
NRMLD
fig|478006.5.peg.634
Escherichia coli O157:H7 str. EC4501 (1-328/339)
MTV
R
V
A
INGFGRIGR
N
V
V
R
A
L
Y
E
SG
R
R
A
EI
T
VVAIN
E
L
A
DA
AG
MA
H
LLKYD
T
SHGRF
A
W
E
V
RQER
D
Q
L
F
V
G
DD
A
IRV
L
H
ER
SLQ
S
LPW
R
E
L
GVDVV
L
D
CTG
V
Y
G
S
R
E
HG
EAHI
A
AGAKKVL
F
S
H
P
G
S
N
D
LDA
T
V
VYGVN
Q
D
Q
L
R
A
E
H
R
IVSNASCTTNC
II
PV
I
K
L
LDDA
Y
GIE
S
GT
V
TTIH
S
A
M
H
D
Q
QV
I
D
A
-
Y
H
P
DLR
RT
RAASQ
S
IIP
VD
T
KL
A
AG
I
T
R
F
F
P
QF
N
DRF
E
A
I
A
V
RVPT
I
NV
TA
I
DL
S
V
T
V
K
K
P
V
K
A
N
EVN
L
L
L
Q
K
AA
Q
G
AFH
G
IV
D
YTE
LP
LVS
V
DFN
H
DPHS
AIV
D
G
TQ
-
--
T
R
V
S
G
AH
L
I
KT
L
V
W
C
DNE
W
GF
A
NRMLD
fig|478007.5.peg.365
Escherichia coli O157:H7 str. EC508 (1-328/339)
MTV
R
V
A
INGFGRIGR
N
V
V
R
A
L
Y
E
SG
R
R
A
EI
T
VVAIN
E
L
A
DA
AG
MA
H
LLKYD
T
SHGRF
A
W
E
V
RQER
D
Q
L
F
V
G
DD
A
IRV
L
H
ER
SLQ
S
LPW
R
E
L
GVDVV
L
D
CTG
V
Y
G
S
R
E
HG
EAHI
A
AGAKKVL
F
S
H
P
G
S
N
D
LDA
T
V
VYGVN
Q
D
Q
L
R
A
E
H
R
IVSNASCTTNC
II
PV
I
K
L
LDDA
Y
GIE
S
GT
V
TTIH
S
A
M
H
D
Q
QV
I
D
A
-
Y
H
P
DLR
RT
RAASQ
S
IIP
VD
T
KL
A
AG
I
T
R
F
F
P
QF
N
DRF
E
A
I
A
V
RVPT
I
NV
TA
I
DL
S
V
T
V
K
K
P
V
K
A
N
EVN
L
L
L
Q
K
AA
Q
G
AFH
G
IV
D
YTE
LP
LVS
V
DFN
H
DPHS
AIV
D
G
TQ
-
--
T
R
V
S
G
AH
L
I
KT
L
V
W
C
DNE
W
GF
A
NRMLD
fig|478008.5.peg.1115
Escherichia coli O157:H7 str. EC869 (1-328/339)
MTV
R
V
A
INGFGRIGR
N
V
V
R
A
L
Y
E
SG
R
R
A
EI
T
VVAIN
E
L
A
DA
AG
MA
H
LLKYD
T
SHGRF
A
W
E
V
RQER
D
Q
L
F
V
G
DD
A
IRV
L
H
ER
SLQ
S
LPW
R
E
L
GVDVV
L
D
CTG
V
Y
G
S
R
E
HG
EAHI
A
AGAKKVL
F
S
H
P
G
S
N
D
LDA
T
V
VYGVN
Q
D
Q
L
R
A
E
H
R
IVSNASCTTNC
II
PV
I
K
L
LDDA
Y
GIE
S
GT
V
TTIH
S
A
M
H
D
Q
QV
I
D
A
-
Y
H
P
DLR
RT
RAASQ
S
IIP
VD
T
KL
A
AG
I
T
R
F
F
P
QF
N
DRF
E
A
I
A
V
RVPT
I
NV
TA
I
DL
S
V
T
V
K
K
P
V
K
A
N
EVN
L
L
L
Q
K
AA
Q
G
AFH
G
IV
D
YTE
LP
LVS
V
DFN
H
DPHS
AIV
D
G
TQ
-
--
T
R
V
S
G
AH
L
I
KT
L
V
W
C
DNE
W
GF
A
NRMLD
fig|637388.3.peg.3345
Escherichia coli O157:H7 str. FRIK2000 (1-328/339)
MTV
R
V
A
INGFGRIGR
N
V
V
R
A
L
Y
E
SG
R
R
A
EI
T
VVAIN
E
L
A
DA
AG
MA
H
LLKYD
T
SHGRF
A
W
E
V
RQER
D
Q
L
F
V
G
DD
A
IRV
L
H
ER
SLQ
S
LPW
R
E
L
GVDVV
L
D
CTG
V
Y
G
S
R
E
HG
EAHI
A
AGAKKVL
F
S
H
P
G
S
N
D
LDA
T
V
VYGVN
Q
D
Q
L
R
A
E
H
R
IVSNASCTTNC
II
PV
I
K
L
LDDA
Y
GIE
S
GT
V
TTIH
S
A
M
H
D
Q
QV
I
D
A
-
Y
H
P
DLR
RT
RAASQ
S
IIP
VD
T
KL
A
AG
I
T
R
F
F
P
QF
N
DRF
E
A
I
A
V
RVPT
I
NV
TA
I
DL
S
V
T
V
K
K
P
V
K
A
N
EVN
L
L
L
Q
K
AA
Q
G
AFH
G
IV
D
YTE
LP
LVS
V
DFN
H
DPHS
AIV
D
G
TQ
-
--
T
R
V
S
G
AH
L
I
KT
L
V
W
C
DNE
W
GF
A
NRMLD
fig|570506.3.peg.2373
Escherichia coli O157:H7 str. FRIK966 (1-328/339)
MTV
R
V
A
INGFGRIGR
N
V
V
R
A
L
Y
E
SG
R
R
A
EI
T
VVAIN
E
L
A
DA
AG
MA
H
LLKYD
T
SHGRF
A
W
E
V
RQER
D
Q
L
F
V
G
DD
A
IRV
L
H
ER
SLQ
S
LPW
R
E
L
GVDVV
L
D
CTG
V
Y
G
S
R
E
HG
EAHI
A
AGAKKVL
F
S
H
P
G
S
N
D
LDA
T
V
VYGVN
Q
D
Q
L
R
A
E
H
R
IVSNASCTTNC
II
PV
I
K
L
LDDA
Y
GIE
S
GT
V
TTIH
S
A
M
H
D
Q
QV
I
D
A
-
Y
H
P
DLR
RT
RAASQ
S
IIP
VD
T
KL
A
AG
I
T
R
F
F
P
QF
N
DRF
E
A
I
A
V
RVPT
I
NV
TA
I
DL
S
V
T
V
K
K
P
V
K
A
N
EVN
L
L
L
Q
K
AA
Q
G
AFH
G
IV
D
YTE
LP
LVS
V
DFN
H
DPHS
AIV
D
G
TQ
-
--
T
R
V
S
G
AH
L
I
KT
L
V
W
C
DNE
W
GF
A
NRMLD
fig|386585.9.peg.3964
Escherichia coli O157:H7 str. Sakai (1-328/339)
MTV
R
V
A
INGFGRIGR
N
V
V
R
A
L
Y
E
SG
R
R
A
EI
T
VVAIN
E
L
A
DA
AG
MA
H
LLKYD
T
SHGRF
A
W
E
V
RQER
D
Q
L
F
V
G
DD
A
IRV
L
H
ER
SLQ
S
LPW
R
E
L
GVDVV
L
D
CTG
V
Y
G
S
R
E
HG
EAHI
A
AGAKKVL
F
S
H
P
G
S
N
D
LDA
T
V
VYGVN
Q
D
Q
L
R
A
E
H
R
IVSNASCTTNC
II
PV
I
K
L
LDDA
Y
GIE
S
GT
V
TTIH
S
A
M
H
D
Q
QV
I
D
A
-
Y
H
P
DLR
RT
RAASQ
S
IIP
VD
T
KL
A
AG
I
T
R
F
F
P
QF
N
DRF
E
A
I
A
V
RVPT
I
NV
TA
I
DL
S
V
T
V
K
K
P
V
K
A
N
EVN
L
L
L
Q
K
AA
Q
G
AFH
G
IV
D
YTE
LP
LVS
V
DFN
H
DPHS
AIV
D
G
TQ
-
--
T
R
V
S
G
AH
L
I
KT
L
V
W
C
DNE
W
GF
A
NRMLD
fig|544404.4.peg.3949
Escherichia coli O157:H7 str. TW14359 (1-328/339)
MTV
R
V
A
INGFGRIGR
N
V
V
R
A
L
Y
E
SG
R
R
A
EI
T
VVAIN
E
L
A
DA
AG
MA
H
LLKYD
T
SHGRF
A
W
E
V
RQER
D
Q
L
F
V
G
DD
A
IRV
L
H
ER
SLQ
S
LPW
R
E
L
GVDVV
L
D
CTG
V
Y
G
S
R
E
HG
EAHI
A
AGAKKVL
F
S
H
P
G
S
N
D
LDA
T
V
VYGVN
Q
D
Q
L
R
A
E
H
R
IVSNASCTTNC
II
PV
I
K
L
LDDA
Y
GIE
S
GT
V
TTIH
S
A
M
H
D
Q
QV
I
D
A
-
Y
H
P
DLR
RT
RAASQ
S
IIP
VD
T
KL
A
AG
I
T
R
F
F
P
QF
N
DRF
E
A
I
A
V
RVPT
I
NV
TA
I
DL
S
V
T
V
K
K
P
V
K
A
N
EVN
L
L
L
Q
K
AA
Q
G
AFH
G
IV
D
YTE
LP
LVS
V
DFN
H
DPHS
AIV
D
G
TQ
-
--
T
R
V
S
G
AH
L
I
KT
L
V
W
C
DNE
W
GF
A
NRMLD
fig|502346.5.peg.3459
Escherichia coli O157:H7 str. TW14588 (1-328/339)
MTV
R
V
A
INGFGRIGR
N
V
V
R
A
L
Y
E
SG
R
R
A
EI
T
VVAIN
E
L
A
DA
AG
MA
H
LLKYD
T
SHGRF
A
W
E
V
RQER
D
Q
L
F
V
G
DD
A
IRV
L
H
ER
SLQ
S
LPW
R
E
L
GVDVV
L
D
CTG
V
Y
G
S
R
E
HG
EAHI
A
AGAKKVL
F
S
H
P
G
S
N
D
LDA
T
V
VYGVN
Q
D
Q
L
R
A
E
H
R
IVSNASCTTNC
II
PV
I
K
L
LDDA
Y
GIE
S
GT
V
TTIH
S
A
M
H
D
Q
QV
I
D
A
-
Y
H
P
DLR
RT
RAASQ
S
IIP
VD
T
KL
A
AG
I
T
R
F
F
P
QF
N
DRF
E
A
I
A
V
RVPT
I
NV
TA
I
DL
S
V
T
V
K
K
P
V
K
A
N
EVN
L
L
L
Q
K
AA
Q
G
AFH
G
IV
D
YTE
LP
LVS
V
DFN
H
DPHS
AIV
D
G
TQ
-
--
T
R
V
S
G
AH
L
I
KT
L
V
W
C
DNE
W
GF
A
NRMLD
fig|573235.3.peg.4104
Escherichia coli O26:H11 str. 11368 (1-328/339)
MTV
R
V
A
INGFGRIGR
N
V
V
R
A
L
Y
E
SG
R
R
A
EI
T
VVAIN
E
L
A
DA
AG
MA
H
LLKYD
T
SHGRF
A
W
E
V
RQER
D
Q
L
F
V
G
DD
A
IRV
L
H
ER
SLQ
S
LPW
R
E
L
GVDVV
L
D
CTG
V
Y
G
S
R
E
HG
EAHI
A
AGAKKVL
F
S
H
P
G
S
N
D
LDA
T
V
VYGVN
Q
D
Q
L
R
A
E
H
R
IVSNASCTTNC
II
PV
I
K
L
LDDA
Y
GIE
S
GT
V
TTIH
S
A
M
H
D
Q
QV
I
D
A
-
Y
H
P
DLR
RT
RAASQ
S
IIP
VD
T
KL
A
AG
I
T
R
F
F
P
QF
N
DRF
E
A
I
A
V
RVPT
I
NV
TA
I
DL
S
V
T
V
K
K
P
V
K
A
N
EVN
L
L
L
Q
K
AA
Q
G
AFH
G
IV
D
YTE
LP
LVS
V
DFN
H
DPHS
AIV
D
G
TQ
-
--
T
R
V
S
G
AH
L
I
KT
L
V
W
C
DNE
W
GF
A
NRMLD
fig|701177.3.peg.3595
Escherichia coli O55:H7 str. CB9615 (1-328/339)
MTV
R
V
A
INGFGRIGR
N
V
V
R
A
L
Y
E
SG
R
R
A
EI
T
VVAIN
E
L
A
DA
AG
MA
H
LLKYD
T
SHGRF
A
W
E
V
RQER
D
Q
L
F
V
G
DD
A
IRV
L
H
ER
SLQ
S
LPW
R
E
L
GVDVV
L
D
CTG
V
Y
G
S
R
E
HG
EAHI
A
AGAKKVL
F
S
H
P
G
S
N
D
LDA
T
V
VYGVN
Q
D
Q
L
R
A
E
H
R
IVSNASCTTNC
II
PV
I
K
L
LDDA
Y
GIE
S
GT
V
TTIH
S
A
M
H
D
Q
QV
I
D
A
-
Y
H
P
DLR
RT
RAASQ
S
IIP
VD
T
KL
A
AG
I
T
R
F
F
P
QF
N
DRF
E
A
I
A
V
RVPT
I
NV
TA
I
DL
S
V
T
V
K
K
P
V
K
A
N
EVN
L
L
L
Q
K
AA
Q
G
AFH
G
IV
D
YTE
LP
LVS
V
DFN
H
DPHS
AIV
D
G
TQ
-
--
T
R
V
S
G
AH
L
I
KT
L
V
W
C
DNE
W
GF
A
NRMLD
fig|409438.11.peg.3362
Escherichia coli SE11 (1-328/339)
MTV
R
V
A
INGFGRIGR
N
V
V
R
A
L
Y
E
SG
R
R
A
EI
T
VVAIN
E
L
A
DA
AG
MA
H
LLKYD
T
SHGRF
A
W
E
V
RQER
D
Q
L
F
V
G
DD
A
IRV
L
H
ER
SLQ
S
LPW
R
E
L
GVDVV
L
D
CTG
V
Y
G
S
R
E
HG
EAHI
A
AGAKKVL
F
S
H
P
G
S
N
D
LDA
T
V
VYGVN
Q
D
Q
L
R
A
E
H
R
IVSNASCTTNC
II
PV
I
K
L
LDDA
Y
GIE
S
GT
V
TTIH
S
A
M
H
D
Q
QV
I
D
A
-
Y
H
P
DLR
RT
RAASQ
S
IIP
VD
T
KL
A
AG
I
T
R
F
F
P
QF
N
DRF
E
A
I
A
V
RVPT
I
NV
TA
I
DL
S
V
T
V
K
K
P
V
K
A
N
EVN
L
L
L
Q
K
AA
Q
G
AFH
G
IV
D
YTE
LP
LVS
V
DFN
H
DPHS
AIV
D
G
TQ
-
--
T
R
V
S
G
AH
L
I
KT
L
V
W
C
DNE
W
GF
A
NRMLD
fig|431946.3.peg.2848
Escherichia coli SE15 (1-328/339)
MTV
R
V
A
INGFGRIGR
N
V
V
R
A
L
Y
E
SG
R
R
A
EI
T
VVAIN
E
L
A
DA
AG
MA
H
LLKYD
T
SHGRF
A
W
E
V
RQER
D
Q
L
F
V
G
DD
A
IRV
L
H
ER
SLQ
S
LPW
R
E
L
GVDVV
L
D
CTG
V
Y
G
S
R
E
HG
EAHI
A
AGAKKVL
F
S
H
P
G
S
N
D
LDA
T
V
VYGVN
Q
D
Q
L
R
A
E
H
R
IVSNASCTTNC
II
PV
I
K
L
LDDA
Y
GIE
S
GT
V
TTIH
S
A
M
H
D
Q
QV
I
D
A
-
Y
H
P
DLR
RT
RAASQ
S
IIP
VD
T
KL
A
AG
I
T
R
F
F
P
QF
N
DRF
E
A
I
A
V
RVPT
I
NV
TA
I
DL
S
V
T
V
K
K
P
V
K
A
N
EVN
L
L
L
Q
K
AA
Q
G
AFH
G
IV
D
YTE
LP
LVS
V
DFN
H
DPHS
AIV
D
G
TQ
-
--
T
R
V
S
G
AH
L
I
KT
L
V
W
C
DNE
W
GF
A
NRMLD
fig|439855.10.peg.3216
Escherichia coli SMS-3-5 (1-328/339)
MTV
R
V
A
INGFGRIGR
N
V
V
R
A
L
Y
E
SG
R
R
A
EI
T
VVAIN
E
L
A
DA
AG
MA
H
LLKYD
T
SHGRF
A
W
E
V
RQER
D
Q
L
F
V
G
DD
A
IRV
L
H
ER
SLQ
S
LPW
R
E
L
GVDVV
L
D
CTG
V
Y
G
S
R
E
HG
EAHI
A
AGAKKVL
F
S
H
P
G
S
N
D
LDA
T
V
VYGVN
Q
D
Q
L
R
A
E
H
R
IVSNASCTTNC
II
PV
I
K
L
LDDA
Y
GIE
S
GT
V
TTIH
S
A
M
H
D
Q
QV
I
D
A
-
Y
H
P
DLR
RT
RAASQ
S
IIP
VD
T
KL
A
AG
I
T
R
F
F
P
QF
N
DRF
E
A
I
A
V
RVPT
I
NV
TA
I
DL
S
V
T
V
K
K
P
V
K
A
N
EVN
L
L
L
Q
K
AA
Q
G
AFH
G
IV
D
YTE
LP
LVS
V
DFN
H
DPHS
AIV
D
G
TQ
-
--
T
R
V
S
G
AH
L
I
KT
L
V
W
C
DNE
W
GF
A
NRMLD
fig|656437.3.peg.3288
Escherichia coli TA143 (1-328/339)
MTV
R
V
A
INGFGRIGR
N
V
V
R
A
L
Y
E
SG
R
R
A
EI
T
VVAIN
E
L
A
DA
AG
MA
H
LLKYD
T
SHGRF
A
W
E
V
RQER
D
Q
L
F
V
G
DD
A
IRV
L
H
ER
SLQ
S
LPW
R
E
L
GVDVV
L
D
CTG
V
Y
G
S
R
E
HG
EAHI
A
AGAKKVL
F
S
H
P
G
S
N
D
LDA
T
V
VYGVN
Q
D
Q
L
R
A
E
H
R
IVSNASCTTNC
II
PV
I
K
L
LDDA
Y
GIE
S
GT
V
TTIH
S
A
M
H
D
Q
QV
I
D
A
-
Y
H
P
DLR
RT
RAASQ
S
IIP
VD
T
KL
A
AG
I
T
R
F
F
P
QF
N
DRF
E
A
I
A
V
RVPT
I
NV
TA
I
DL
S
V
T
V
K
K
P
V
K
A
N
EVN
L
L
L
Q
K
AA
Q
G
AFH
G
IV
D
YTE
LP
LVS
V
DFN
H
DPHS
AIV
D
G
TQ
-
--
T
R
V
S
G
AH
L
I
KT
L
V
W
C
DNE
W
GF
A
NRMLD
fig|656440.3.peg.2969
Escherichia coli TA206 (1-328/339)
MTV
R
V
A
INGFGRIGR
N
V
V
R
A
L
Y
E
SG
R
R
A
EI
T
VVAIN
E
L
A
DA
AG
MA
H
LLKYD
T
SHGRF
A
W
E
V
RQER
D
Q
L
F
V
G
DD
A
IRV
L
H
ER
SLQ
S
LPW
R
E
L
GVDVV
L
D
CTG
V
Y
G
S
R
E
HG
EAHI
A
AGAKKVL
F
S
H
P
G
S
N
D
LDA
T
V
VYGVN
Q
D
Q
L
R
A
E
H
R
IVSNASCTTNC
II
PV
I
K
L
LDDA
Y
GIE
S
GT
V
TTIH
S
A
M
H
D
Q
QV
I
D
A
-
Y
H
P
DLR
RT
RAASQ
S
IIP
VD
T
KL
A
AG
I
T
R
F
F
P
QF
N
DRF
E
A
I
A
V
RVPT
I
NV
TA
I
DL
S
V
T
V
K
K
P
V
K
A
N
EVN
L
L
L
Q
K
AA
Q
G
AFH
G
IV
D
YTE
LP
LVS
V
DFN
H
DPHS
AIV
D
G
TQ
-
--
T
R
V
S
G
AH
L
I
KT
L
V
W
C
DNE
W
GF
A
NRMLD
fig|656443.3.peg.3708
Escherichia coli TA271 (1-328/339)
MTV
R
V
A
INGFGRIGR
N
V
V
R
A
L
Y
E
SG
R
R
A
EI
T
VVAIN
E
L
A
DA
AG
MA
H
LLKYD
T
SHGRF
A
W
E
V
RQER
D
Q
L
F
V
G
DD
A
IRV
L
H
ER
SLQ
S
LPW
R
E
L
GVDVV
L
D
CTG
V
Y
G
S
R
E
HG
EAHI
A
AGAKKVL
F
S
H
P
G
S
N
D
LDA
T
V
VYGVN
Q
D
Q
L
R
A
E
H
R
IVSNASCTTNC
II
PV
I
K
L
LDDA
Y
GIE
S
GT
V
TTIH
S
A
M
H
D
Q
QV
I
D
A
-
Y
H
P
DLR
RT
RAASQ
S
IIP
VD
T
KL
A
AG
I
T
R
F
F
P
QF
N
DRF
E
A
I
A
V
RVPT
I
NV
TA
I
DL
S
V
T
V
K
K
P
V
K
A
N
EVN
L
L
L
Q
K
AA
Q
G
AFH
G
IV
D
YTE
LP
LVS
V
DFN
H
DPHS
AIV
D
G
TQ
-
--
T
R
V
S
G
AH
L
I
KT
L
V
W
C
DNE
W
GF
A
NRMLD
fig|585056.7.peg.3450
Escherichia coli UMN026 (1-328/339)
MTV
R
V
A
INGFGRIGR
N
V
V
R
A
L
Y
E
SG
R
R
A
EI
T
VVAIN
E
L
A
DA
AG
MA
H
LLKYD
T
SHGRF
A
W
E
V
RQER
D
Q
L
F
V
G
DD
A
IRV
L
H
ER
SLQ
S
LPW
R
E
L
GVDVV
L
D
CTG
V
Y
G
S
R
E
HG
EAHI
A
AGAKKVL
F
S
H
P
G
S
N
D
LDA
T
V
VYGVN
Q
D
Q
L
R
A
E
H
R
IVSNASCTTNC
II
PV
I
K
L
LDDA
Y
GIE
S
GT
V
TTIH
S
A
M
H
D
Q
QV
I
D
A
-
Y
H
P
DLR
RT
RAASQ
S
IIP
VD
T
KL
A
AG
I
T
R
F
F
P
QF
N
DRF
E
A
I
A
V
RVPT
I
NV
TA
I
DL
S
V
T
V
K
K
P
V
K
A
N
EVN
L
L
L
Q
K
AA
Q
G
AFH
G
IV
D
YTE
LP
LVS
V
DFN
H
DPHS
AIV
D
G
TQ
-
--
T
R
V
S
G
AH
L
I
KT
L
V
W
C
DNE
W
GF
A
NRMLD
fig|566546.3.peg.707
Escherichia coli W (1-328/339)
MTV
R
V
A
INGFGRIGR
N
V
V
R
A
L
Y
E
SG
R
R
A
EI
T
VVAIN
E
L
A
DA
AG
MA
H
LLKYD
T
SHGRF
A
W
E
V
RQER
D
Q
L
F
V
G
DD
A
IRV
L
H
ER
SLQ
S
LPW
R
E
L
GVDVV
L
D
CTG
V
Y
G
S
R
E
HG
EAHI
A
AGAKKVL
F
S
H
P
G
S
N
D
LDA
T
V
VYGVN
Q
D
Q
L
R
A
E
H
R
IVSNASCTTNC
II
PV
I
K
L
LDDA
Y
GIE
S
GT
V
TTIH
S
A
M
H
D
Q
QV
I
D
A
-
Y
H
P
DLR
RT
RAASQ
S
IIP
VD
T
KL
A
AG
I
T
R
F
F
P
QF
N
DRF
E
A
I
A
V
RVPT
I
NV
TA
I
DL
S
V
T
V
K
K
P
V
K
A
N
EVN
L
L
L
Q
K
AA
Q
G
AFH
G
IV
D
YTE
LP
LVS
V
DFN
H
DPHS
AIV
D
G
TQ
-
--
T
R
V
S
G
AH
L
I
KT
L
V
W
C
DNE
W
GF
A
NRMLD
fig|566546.4.peg.3143
Escherichia coli W (1-328/339)
MTV
R
V
A
INGFGRIGR
N
V
V
R
A
L
Y
E
SG
R
R
A
EI
T
VVAIN
E
L
A
DA
AG
MA
H
LLKYD
T
SHGRF
A
W
E
V
RQER
D
Q
L
F
V
G
DD
A
IRV
L
H
ER
SLQ
S
LPW
R
E
L
GVDVV
L
D
CTG
V
Y
G
S
R
E
HG
EAHI
A
AGAKKVL
F
S
H
P
G
S
N
D
LDA
T
V
VYGVN
Q
D
Q
L
R
A
E
H
R
IVSNASCTTNC
II
PV
I
K
L
LDDA
Y
GIE
S
GT
V
TTIH
S
A
M
H
D
Q
QV
I
D
A
-
Y
H
P
DLR
RT
RAASQ
S
IIP
VD
T
KL
A
AG
I
T
R
F
F
P
QF
N
DRF
E
A
I
A
V
RVPT
I
NV
TA
I
DL
S
V
T
V
K
K
P
V
K
A
N
EVN
L
L
L
Q
K
AA
Q
G
AFH
G
IV
D
YTE
LP
LVS
V
DFN
H
DPHS
AIV
D
G
TQ
-
--
T
R
V
S
G
AH
L
I
KT
L
V
W
C
DNE
W
GF
A
NRMLD
fig|316407.3.peg.2821
Escherichia coli W3110 (1-328/339)
MTV
R
V
A
INGFGRIGR
N
V
V
R
A
L
Y
E
SG
R
R
A
EI
T
VVAIN
E
L
A
DA
AG
MA
H
LLKYD
T
SHGRF
A
W
E
V
RQER
D
Q
L
F
V
G
DD
A
IRV
L
H
ER
SLQ
S
LPW
R
E
L
GVDVV
L
D
CTG
V
Y
G
S
R
E
HG
EAHI
A
AGAKKVL
F
S
H
P
G
S
N
D
LDA
T
V
VYGVN
Q
D
Q
L
R
A
E
H
R
IVSNASCTTNC
II
PV
I
K
L
LDDA
Y
GIE
S
GT
V
TTIH
S
A
M
H
D
Q
QV
I
D
A
-
Y
H
P
DLR
RT
RAASQ
S
IIP
VD
T
KL
A
AG
I
T
R
F
F
P
QF
N
DRF
E
A
I
A
V
RVPT
I
NV
TA
I
DL
S
V
T
V
K
K
P
V
K
A
N
EVN
L
L
L
Q
K
AA
Q
G
AFH
G
IV
D
YTE
LP
LVS
V
DFN
H
DPHS
AIV
D
G
TQ
-
--
T
R
V
S
G
AH
L
I
KT
L
V
W
C
DNE
W
GF
A
NRMLD
fig|562.376.peg.3732
Escherichia coli WV_060327 (1-328/339)
MTV
R
V
A
INGFGRIGR
N
V
V
R
A
L
Y
E
SG
R
R
A
EI
T
VVAIN
E
L
A
DA
AG
MA
H
LLKYD
T
SHGRF
A
W
E
V
RQER
D
Q
L
F
V
G
DD
A
IRV
L
H
ER
SLQ
S
LPW
R
E
L
GVDVV
L
D
CTG
V
Y
G
S
R
E
HG
EAHI
A
AGAKKVL
F
S
H
P
G
S
N
D
LDA
T
V
VYGVN
Q
D
Q
L
R
A
E
H
R
IVSNASCTTNC
II
PV
I
K
L
LDDA
Y
GIE
S
GT
V
TTIH
S
A
M
H
D
Q
QV
I
D
A
-
Y
H
P
DLR
RT
RAASQ
S
IIP
VD
T
KL
A
AG
I
T
R
F
F
P
QF
N
DRF
E
A
I
A
V
RVPT
I
NV
TA
I
DL
S
V
T
V
K
K
P
V
K
A
N
EVN
L
L
L
Q
K
AA
Q
G
AFH
G
IV
D
YTE
LP
LVS
V
DFN
H
DPHS
AIV
D
G
TQ
-
--
T
R
V
S
G
AH
L
I
KT
L
V
W
C
DNE
W
GF
A
NRMLD
fig|316385.5.peg.3052
Escherichia coli str. K-12 substr. DH10B (1-328/339)
MTV
R
V
A
INGFGRIGR
N
V
V
R
A
L
Y
E
SG
R
R
A
EI
T
VVAIN
E
L
A
DA
AG
MA
H
LLKYD
T
SHGRF
A
W
E
V
RQER
D
Q
L
F
V
G
DD
A
IRV
L
H
ER
SLQ
S
LPW
R
E
L
GVDVV
L
D
CTG
V
Y
G
S
R
E
HG
EAHI
A
AGAKKVL
F
S
H
P
G
S
N
D
LDA
T
V
VYGVN
Q
D
Q
L
R
A
E
H
R
IVSNASCTTNC
II
PV
I
K
L
LDDA
Y
GIE
S
GT
V
TTIH
S
A
M
H
D
Q
QV
I
D
A
-
Y
H
P
DLR
RT
RAASQ
S
IIP
VD
T
KL
A
AG
I
T
R
F
F
P
QF
N
DRF
E
A
I
A
V
RVPT
I
NV
TA
I
DL
S
V
T
V
K
K
P
V
K
A
N
EVN
L
L
L
Q
K
AA
Q
G
AFH
G
IV
D
YTE
LP
LVS
V
DFN
H
DPHS
AIV
D
G
TQ
-
--
T
R
V
S
G
AH
L
I
KT
L
V
W
C
DNE
W
GF
A
NRMLD
fig|316385.7.peg.3120
Escherichia coli str. K-12 substr. DH10B (1-328/339)
MTV
R
V
A
INGFGRIGR
N
V
V
R
A
L
Y
E
SG
R
R
A
EI
T
VVAIN
E
L
A
DA
AG
MA
H
LLKYD
T
SHGRF
A
W
E
V
RQER
D
Q
L
F
V
G
DD
A
IRV
L
H
ER
SLQ
S
LPW
R
E
L
GVDVV
L
D
CTG
V
Y
G
S
R
E
HG
EAHI
A
AGAKKVL
F
S
H
P
G
S
N
D
LDA
T
V
VYGVN
Q
D
Q
L
R
A
E
H
R
IVSNASCTTNC
II
PV
I
K
L
LDDA
Y
GIE
S
GT
V
TTIH
S
A
M
H
D
Q
QV
I
D
A
-
Y
H
P
DLR
RT
RAASQ
S
IIP
VD
T
KL
A
AG
I
T
R
F
F
P
QF
N
DRF
E
A
I
A
V
RVPT
I
NV
TA
I
DL
S
V
T
V
K
K
P
V
K
A
N
EVN
L
L
L
Q
K
AA
Q
G
AFH
G
IV
D
YTE
LP
LVS
V
DFN
H
DPHS
AIV
D
G
TQ
-
--
T
R
V
S
G
AH
L
I
KT
L
V
W
C
DNE
W
GF
A
NRMLD
fig|511145.12.peg.3022
Escherichia coli str. K-12 substr. MG1655 (1-328/339)
MTV
R
V
A
INGFGRIGR
N
V
V
R
A
L
Y
E
SG
R
R
A
EI
T
VVAIN
E
L
A
DA
AG
MA
H
LLKYD
T
SHGRF
A
W
E
V
RQER
D
Q
L
F
V
G
DD
A
IRV
L
H
ER
SLQ
S
LPW
R
E
L
GVDVV
L
D
CTG
V
Y
G
S
R
E
HG
EAHI
A
AGAKKVL
F
S
H
P
G
S
N
D
LDA
T
V
VYGVN
Q
D
Q
L
R
A
E
H
R
IVSNASCTTNC
II
PV
I
K
L
LDDA
Y
GIE
S
GT
V
TTIH
S
A
M
H
D
Q
QV
I
D
A
-
Y
H
P
DLR
RT
RAASQ
S
IIP
VD
T
KL
A
AG
I
T
R
F
F
P
QF
N
DRF
E
A
I
A
V
RVPT
I
NV
TA
I
DL
S
V
T
V
K
K
P
V
K
A
N
EVN
L
L
L
Q
K
AA
Q
G
AFH
G
IV
D
YTE
LP
LVS
V
DFN
H
DPHS
AIV
D
G
TQ
-
--
T
R
V
S
G
AH
L
I
KT
L
V
W
C
DNE
W
GF
A
NRMLD
fig|511145.6.peg.3007
Escherichia coli str. K-12 substr. MG1655 (1-328/339)
MTV
R
V
A
INGFGRIGR
N
V
V
R
A
L
Y
E
SG
R
R
A
EI
T
VVAIN
E
L
A
DA
AG
MA
H
LLKYD
T
SHGRF
A
W
E
V
RQER
D
Q
L
F
V
G
DD
A
IRV
L
H
ER
SLQ
S
LPW
R
E
L
GVDVV
L
D
CTG
V
Y
G
S
R
E
HG
EAHI
A
AGAKKVL
F
S
H
P
G
S
N
D
LDA
T
V
VYGVN
Q
D
Q
L
R
A
E
H
R
IVSNASCTTNC
II
PV
I
K
L
LDDA
Y
GIE
S
GT
V
TTIH
S
A
M
H
D
Q
QV
I
D
A
-
Y
H
P
DLR
RT
RAASQ
S
IIP
VD
T
KL
A
AG
I
T
R
F
F
P
QF
N
DRF
E
A
I
A
V
RVPT
I
NV
TA
I
DL
S
V
T
V
K
K
P
V
K
A
N
EVN
L
L
L
Q
K
AA
Q
G
AFH
G
IV
D
YTE
LP
LVS
V
DFN
H
DPHS
AIV
D
G
TQ
-
--
T
R
V
S
G
AH
L
I
KT
L
V
W
C
DNE
W
GF
A
NRMLD
fig|670897.3.peg.541
Escherichia coli 2362-75 (1-328/339)
MTV
R
V
A
INGFGRIGR
N
V
V
R
A
L
Y
E
SG
R
R
A
EI
T
VVAIN
E
L
A
DA
AG
MA
H
LLKYD
T
SHGRF
A
W
E
V
RQER
D
Q
L
F
V
G
DD
A
IRV
L
H
ER
SLQ
S
LPW
R
E
L
GVDVV
L
D
CTG
V
Y
G
S
R
E
HG
EAHI
A
AGAKKVL
F
S
H
P
G
S
N
D
LDT
T
V
VYGVN
Q
D
Q
L
R
A
E
H
R
IVSNASCTTNC
II
PV
I
K
L
LDDA
Y
GIE
S
GT
V
TTIH
S
A
M
H
D
Q
QV
I
D
A
-
Y
H
P
DLR
RT
RAASQ
S
IIP
VD
T
KL
A
AG
I
T
R
F
F
P
QF
N
DRF
E
A
I
A
V
RVPT
I
NV
TA
I
DL
S
V
T
V
K
K
P
V
K
A
N
EVN
L
L
L
Q
K
AA
Q
G
AFH
G
IV
D
YTE
LP
LVS
V
DFN
H
DPHS
AIV
D
G
TQ
-
--
T
R
V
S
G
AH
L
I
KT
L
V
W
C
DNE
W
GF
A
NRMLD
fig|216593.1.peg.5284
Escherichia coli E2348/69 (29-356/367)
MTV
R
V
A
INGFGRIGR
N
V
V
R
A
L
Y
E
SG
R
R
A
EI
T
VVAIN
E
L
A
DA
AG
MA
H
LLKYD
T
SHGRF
A
W
E
V
RQER
D
Q
L
F
V
G
DD
A
IRV
L
H
ER
SLQ
S
LPW
R
E
L
GVDVV
L
D
CTG
V
Y
G
S
R
E
HG
EAHI
A
AGAKKVL
F
S
H
P
G
S
N
D
LDT
T
V
VYGVN
Q
D
Q
L
R
A
E
H
R
IVSNASCTTNC
II
PV
I
K
L
LDDA
Y
GIE
S
GT
V
TTIH
S
A
M
H
D
Q
QV
I
D
A
-
Y
H
P
DLR
RT
RAASQ
S
IIP
VD
T
KL
A
AG
I
T
R
F
F
P
QF
N
DRF
E
A
I
A
V
RVPT
I
NV
TA
I
DL
S
V
T
V
K
K
P
V
K
A
N
EVN
L
L
L
Q
K
AA
Q
G
AFH
G
IV
D
YTE
LP
LVS
V
DFN
H
DPHS
AIV
D
G
TQ
-
--
T
R
V
S
G
AH
L
I
KT
L
V
W
C
DNE
W
GF
A
NRMLD
fig|585397.7.peg.3389
Escherichia coli ED1a (1-328/339)
MTV
R
V
A
INGFGRIGR
N
V
V
R
A
L
Y
E
SG
R
R
A
EI
T
VVAIN
E
L
A
DA
AG
MA
H
LLKYD
T
SHGRF
A
W
E
V
RQER
D
Q
L
F
V
G
DD
A
IRV
L
H
ER
SLQ
S
LPW
R
E
L
GVDVV
L
D
CTG
V
Y
G
S
R
E
HG
EAHI
A
AGAKKVL
F
S
H
P
G
S
N
D
LDT
T
V
VYGVN
Q
D
Q
L
R
A
E
H
R
IVSNASCTTNC
II
PV
I
K
L
LDDA
Y
GIE
S
GT
V
TTIH
S
A
M
H
D
Q
QV
I
D
A
-
Y
H
P
DLR
RT
RAASQ
S
IIP
VD
T
KL
A
AG
I
T
R
F
F
P
QF
N
DRF
E
A
I
A
V
RVPT
I
NV
TA
I
DL
S
V
T
V
K
K
P
V
K
A
N
EVN
L
L
L
Q
K
AA
Q
G
AFH
G
IV
D
YTE
LP
LVS
V
DFN
H
DPHS
AIV
D
G
TQ
-
--
T
R
V
S
G
AH
L
I
KT
L
V
W
C
DNE
W
GF
A
NRMLD
fig|585397.9.peg.3385
Escherichia coli ED1a (1-328/339)
MTV
R
V
A
INGFGRIGR
N
V
V
R
A
L
Y
E
SG
R
R
A
EI
T
VVAIN
E
L
A
DA
AG
MA
H
LLKYD
T
SHGRF
A
W
E
V
RQER
D
Q
L
F
V
G
DD
A
IRV
L
H
ER
SLQ
S
LPW
R
E
L
GVDVV
L
D
CTG
V
Y
G
S
R
E
HG
EAHI
A
AGAKKVL
F
S
H
P
G
S
N
D
LDT
T
V
VYGVN
Q
D
Q
L
R
A
E
H
R
IVSNASCTTNC
II
PV
I
K
L
LDDA
Y
GIE
S
GT
V
TTIH
S
A
M
H
D
Q
QV
I
D
A
-
Y
H
P
DLR
RT
RAASQ
S
IIP
VD
T
KL
A
AG
I
T
R
F
F
P
QF
N
DRF
E
A
I
A
V
RVPT
I
NV
TA
I
DL
S
V
T
V
K
K
P
V
K
A
N
EVN
L
L
L
Q
K
AA
Q
G
AFH
G
IV
D
YTE
LP
LVS
V
DFN
H
DPHS
AIV
D
G
TQ
-
--
T
R
V
S
G
AH
L
I
KT
L
V
W
C
DNE
W
GF
A
NRMLD
fig|714962.3.peg.3345
Escherichia coli IHE3034 (1-328/339)
MTV
R
V
A
INGFGRIGR
N
V
V
R
A
L
Y
E
SG
R
R
A
EI
T
VVAIN
E
L
A
DA
AG
MA
H
LLKYD
T
SHGRF
A
W
E
V
RQER
D
Q
L
F
V
G
DD
A
IRV
L
H
ER
SLQ
S
LPW
R
E
L
GVDVV
L
D
CTG
V
Y
G
S
R
E
HG
EAHI
A
AGAKKVL
F
S
H
P
G
S
N
D
LDT
T
V
VYGVN
Q
D
Q
L
R
A
E
H
R
IVSNASCTTNC
II
PV
I
K
L
LDDA
Y
GIE
S
GT
V
TTIH
S
A
M
H
D
Q
QV
I
D
A
-
Y
H
P
DLR
RT
RAASQ
S
IIP
VD
T
KL
A
AG
I
T
R
F
F
P
QF
N
DRF
E
A
I
A
V
RVPT
I
NV
TA
I
DL
S
V
T
V
K
K
P
V
K
A
N
EVN
L
L
L
Q
K
AA
Q
G
AFH
G
IV
D
YTE
LP
LVS
V
DFN
H
DPHS
AIV
D
G
TQ
-
--
T
R
V
S
G
AH
L
I
KT
L
V
W
C
DNE
W
GF
A
NRMLD
fig|574521.7.peg.3232
Escherichia coli O127:H6 str. E2348/69 (1-328/339)
MTV
R
V
A
INGFGRIGR
N
V
V
R
A
L
Y
E
SG
R
R
A
EI
T
VVAIN
E
L
A
DA
AG
MA
H
LLKYD
T
SHGRF
A
W
E
V
RQER
D
Q
L
F
V
G
DD
A
IRV
L
H
ER
SLQ
S
LPW
R
E
L
GVDVV
L
D
CTG
V
Y
G
S
R
E
HG
EAHI
A
AGAKKVL
F
S
H
P
G
S
N
D
LDT
T
V
VYGVN
Q
D
Q
L
R
A
E
H
R
IVSNASCTTNC
II
PV
I
K
L
LDDA
Y
GIE
S
GT
V
TTIH
S
A
M
H
D
Q
QV
I
D
A
-
Y
H
P
DLR
RT
RAASQ
S
IIP
VD
T
KL
A
AG
I
T
R
F
F
P
QF
N
DRF
E
A
I
A
V
RVPT
I
NV
TA
I
DL
S
V
T
V
K
K
P
V
K
A
N
EVN
L
L
L
Q
K
AA
Q
G
AFH
G
IV
D
YTE
LP
LVS
V
DFN
H
DPHS
AIV
D
G
TQ
-
--
T
R
V
S
G
AH
L
I
KT
L
V
W
C
DNE
W
GF
A
NRMLD
fig|685038.3.peg.2929
Escherichia coli O83:H1 str. NRG 857C (1-328/339)
MTV
R
V
A
INGFGRIGR
N
V
V
R
A
L
Y
E
SG
R
R
A
EI
T
VVAIN
E
L
A
DA
AG
MA
H
LLKYD
T
SHGRF
A
W
E
V
RQER
D
Q
L
F
V
G
DD
A
IRV
L
H
ER
SLQ
S
LPW
R
E
L
GVDVV
L
D
CTG
V
Y
G
S
R
E
HG
EAHI
A
AGAKKVL
F
S
H
P
G
S
N
D
LDT
T
V
VYGVN
Q
D
Q
L
R
A
E
H
R
IVSNASCTTNC
II
PV
I
K
L
LDDA
Y
GIE
S
GT
V
TTIH
S
A
M
H
D
Q
QV
I
D
A
-
Y
H
P
DLR
RT
RAASQ
S
IIP
VD
T
KL
A
AG
I
T
R
F
F
P
QF
N
DRF
E
A
I
A
V
RVPT
I
NV
TA
I
DL
S
V
T
V
K
K
P
V
K
A
N
EVN
L
L
L
Q
K
AA
Q
G
AFH
G
IV
D
YTE
LP
LVS
V
DFN
H
DPHS
AIV
D
G
TQ
-
--
T
R
V
S
G
AH
L
I
KT
L
V
W
C
DNE
W
GF
A
NRMLD
fig|869729.3.peg.408
Escherichia coli UM146 (1-328/339)
MTV
R
V
A
INGFGRIGR
N
V
V
R
A
L
Y
E
SG
R
R
A
EI
T
VVAIN
E
L
A
DA
AG
MA
H
LLKYD
T
SHGRF
A
W
E
V
RQER
D
Q
L
F
V
G
DD
A
IRV
L
H
ER
SLQ
S
LPW
R
E
L
GVDVV
L
D
CTG
V
Y
G
S
R
E
HG
EAHI
A
AGAKKVL
F
S
H
P
G
S
N
D
LDT
T
V
VYGVN
Q
D
Q
L
R
A
E
H
R
IVSNASCTTNC
II
PV
I
K
L
LDDA
Y
GIE
S
GT
V
TTIH
S
A
M
H
D
Q
QV
I
D
A
-
Y
H
P
DLR
RT
RAASQ
S
IIP
VD
T
KL
A
AG
I
T
R
F
F
P
QF
N
DRF
E
A
I
A
V
RVPT
I
NV
TA
I
DL
S
V
T
V
K
K
P
V
K
A
N
EVN
L
L
L
Q
K
AA
Q
G
AFH
G
IV
D
YTE
LP
LVS
V
DFN
H
DPHS
AIV
D
G
TQ
-
--
T
R
V
S
G
AH
L
I
KT
L
V
W
C
DNE
W
GF
A
NRMLD
fig|364106.7.peg.3281
Escherichia coli UTI89 (1-328/339)
MTV
R
V
A
INGFGRIGR
N
V
V
R
A
L
Y
E
SG
R
R
A
EI
T
VVAIN
E
L
A
DA
AG
MA
H
LLKYD
T
SHGRF
A
W
E
V
RQER
D
Q
L
F
V
G
DD
A
IRV
L
H
ER
SLQ
S
LPW
R
E
L
GVDVV
L
D
CTG
V
Y
G
S
R
E
HG
EAHI
A
AGAKKVL
F
S
H
P
G
S
N
D
LDT
T
V
VYGVN
Q
D
Q
L
R
A
E
H
R
IVSNASCTTNC
II
PV
I
K
L
LDDA
Y
GIE
S
GT
V
TTIH
S
A
M
H
D
Q
QV
I
D
A
-
Y
H
P
DLR
RT
RAASQ
S
IIP
VD
T
KL
A
AG
I
T
R
F
F
P
QF
N
DRF
E
A
I
A
V
RVPT
I
NV
TA
I
DL
S
V
T
V
K
K
P
V
K
A
N
EVN
L
L
L
Q
K
AA
Q
G
AFH
G
IV
D
YTE
LP
LVS
V
DFN
H
DPHS
AIV
D
G
TQ
-
--
T
R
V
S
G
AH
L
I
KT
L
V
W
C
DNE
W
GF
A
NRMLD
fig|364106.8.peg.3282
Escherichia coli UTI89 (1-328/339)
MTV
R
V
A
INGFGRIGR
N
V
V
R
A
L
Y
E
SG
R
R
A
EI
T
VVAIN
E
L
A
DA
AG
MA
H
LLKYD
T
SHGRF
A
W
E
V
RQER
D
Q
L
F
V
G
DD
A
IRV
L
H
ER
SLQ
S
LPW
R
E
L
GVDVV
L
D
CTG
V
Y
G
S
R
E
HG
EAHI
A
AGAKKVL
F
S
H
P
G
S
N
D
LDT
T
V
VYGVN
Q
D
Q
L
R
A
E
H
R
IVSNASCTTNC
II
PV
I
K
L
LDDA
Y
GIE
S
GT
V
TTIH
S
A
M
H
D
Q
QV
I
D
A
-
Y
H
P
DLR
RT
RAASQ
S
IIP
VD
T
KL
A
AG
I
T
R
F
F
P
QF
N
DRF
E
A
I
A
V
RVPT
I
NV
TA
I
DL
S
V
T
V
K
K
P
V
K
A
N
EVN
L
L
L
Q
K
AA
Q
G
AFH
G
IV
D
YTE
LP
LVS
V
DFN
H
DPHS
AIV
D
G
TQ
-
--
T
R
V
S
G
AH
L
I
KT
L
V
W
C
DNE
W
GF
A
NRMLD
fig|656444.3.peg.4064
Escherichia coli TA280 (1-328/339)
MTV
R
V
A
INGFGRIGR
N
V
V
R
A
L
Y
E
SG
R
R
A
EI
T
VVAIN
E
L
A
DA
AG
MA
H
LLKYD
T
SHGRF
A
W
E
V
RQER
D
Q
L
F
V
G
DD
A
IRV
L
H
ER
TLQ
S
LPW
R
E
L
GVDVV
L
D
CTG
V
Y
G
S
R
E
HG
EAHI
A
AGAKKVL
F
S
H
P
G
S
N
D
LDA
T
V
VYGVN
Q
D
Q
L
R
A
E
H
R
IVSNASCTTNC
II
PV
I
K
L
LDDA
Y
GIE
S
GT
V
TTIH
S
A
M
H
D
Q
QV
I
D
A
-
Y
H
P
DLR
RT
RAASQ
S
IIP
VD
T
KL
A
AG
I
T
R
F
F
P
QF
N
DRF
E
A
I
A
V
RVPT
I
NV
TA
I
DL
S
V
T
V
K
K
P
V
K
A
N
EVN
L
L
L
Q
K
AA
Q
G
AFH
G
IV
D
YTE
LP
LVS
V
DFN
H
DPHS
AIV
D
G
TQ
-
--
T
R
V
S
G
AH
L
I
KT
L
V
W
C
DNE
W
GF
A
NRMLD
fig|562.375.peg.1301
Escherichia coli EC4100B (1-328/339)
MTV
R
V
A
INGFGRIGR
N
V
V
R
A
L
Y
E
SG
R
R
A
EI
T
VVAIN
E
L
A
DA
AG
MA
H
LLKYD
T
SHGRF
A
W
E
V
RQER
D
Q
L
F
V
G
DD
A
IRV
L
H
ER
SLQ
S
LPW
R
E
L
GVDVV
L
D
CTG
V
Y
G
S
R
E
HG
EAHI
A
AGAKKVL
F
S
H
P
G
S
N
D
LDA
T
V
VYGVN
Q
D
Q
L
R
A
E
H
R
IVSNASCTTNC
II
PV
I
K
L
LDDA
Y
GIE
S
GT
V
TTIH
S
A
M
H
D
Q
QV
I
D
A
-
Y
H
P
DLR
RT
RAASQ
S
IIP
VD
T
KL
A
AG
I
T
R
F
F
P
QF
N
DRF
E
A
I
A
V
RVPT
I
NV
TA
I
DL
S
V
T
V
K
K
P
V
K
A
N
EVN
L
L
L
Q
K
AA
Q
G
AFH
G
IV
D
YTE
LP
LVS
V
DFN
H
DPHS
AIV
D
G
TQ
-
--
T
R
I
S
G
AH
L
I
KT
L
V
W
C
DNE
W
GF
A
NRMLD
fig|405955.13.peg.3246
Escherichia coli APEC O1 (1-328/339)
MTV
R
V
A
INGFGRIGR
N
V
V
R
A
L
Y
E
SG
R
R
A
EI
T
VVAIN
E
L
A
DA
AG
MA
H
LLKYD
T
SHGRF
A
W
E
V
RQER
D
Q
L
F
V
G
DD
A
IRV
L
H
ER
SLQ
S
LPW
R
E
L
GVDVV
L
D
CTG
V
Y
G
S
R
E
HG
EAHI
A
AGAKKVL
F
S
H
P
G
S
N
D
LDT
T
V
VYGVN
Q
D
Q
L
R
A
E
H
R
IVSNASCTTNC
II
PV
I
K
L
LDDA
Y
GIE
S
GT
V
TTIH
S
A
M
H
D
Q
QV
I
D
A
-
Y
H
P
DLR
RT
RAASQ
S
IIP
VD
T
KL
A
AG
I
T
R
F
F
P
QF
N
DRF
E
A
I
A
V
RVPT
I
NV
TA
I
DL
S
V
T
V
K
K
P
V
K
A
N
EVN
L
L
L
Q
K
AA
Q
G
AFH
G
IV
D
Y
A
E
LP
LVS
V
DFN
H
DPHS
AIV
D
G
TQ
-
--
T
R
V
S
G
AH
L
I
KT
L
V
W
C
DNE
W
GF
A
NRMLD
fig|405955.9.peg.2694
Escherichia coli APEC O1 (29-356/367)
MTV
R
V
A
INGFGRIGR
N
V
V
R
A
L
Y
E
SG
R
R
A
EI
T
VVAIN
E
L
A
DA
AG
MA
H
LLKYD
T
SHGRF
A
W
E
V
RQER
D
Q
L
F
V
G
DD
A
IRV
L
H
ER
SLQ
S
LPW
R
E
L
GVDVV
L
D
CTG
V
Y
G
S
R
E
HG
EAHI
A
AGAKKVL
F
S
H
P
G
S
N
D
LDT
T
V
VYGVN
Q
D
Q
L
R
A
E
H
R
IVSNASCTTNC
II
PV
I
K
L
LDDA
Y
GIE
S
GT
V
TTIH
S
A
M
H
D
Q
QV
I
D
A
-
Y
H
P
DLR
RT
RAASQ
S
IIP
VD
T
KL
A
AG
I
T
R
F
F
P
QF
N
DRF
E
A
I
A
V
RVPT
I
NV
TA
I
DL
S
V
T
V
K
K
P
V
K
A
N
EVN
L
L
L
Q
K
AA
Q
G
AFH
G
IV
D
Y
A
E
LP
LVS
V
DFN
H
DPHS
AIV
D
G
TQ
-
--
T
R
V
S
G
AH
L
I
KT
L
V
W
C
DNE
W
GF
A
NRMLD
fig|585035.6.peg.3143
Escherichia coli S88 (1-328/339)
MTV
R
V
A
INGFGRIGR
N
V
V
R
A
L
Y
E
SG
R
R
A
EI
T
VVAIN
E
L
A
DA
AG
MA
H
LLKYD
T
SHGRF
A
W
E
V
RQER
D
Q
L
F
V
G
DD
A
IRV
L
H
ER
SLQ
S
LPW
R
E
L
GVDVV
L
D
CTG
V
Y
G
S
R
E
HG
EAHI
A
AGAKKVL
F
S
H
P
G
S
N
D
LDT
T
V
VYGVN
Q
D
Q
L
R
A
E
H
R
IVSNASCTTNC
II
PV
I
K
L
LDDA
Y
GIE
S
GT
V
TTIH
S
A
M
H
D
Q
QV
I
D
A
-
Y
H
P
DLR
RT
RAASQ
S
IIP
VD
T
KL
A
AG
I
T
R
F
F
P
QF
N
DRF
E
A
I
A
V
RVPT
I
NV
TA
I
DL
S
V
T
V
K
K
P
V
K
A
N
EVN
L
L
L
Q
K
AA
Q
G
AFH
G
IV
D
Y
A
E
LP
LVS
V
DFN
H
DPHS
AIV
D
G
TQ
-
--
T
R
V
S
G
AH
L
I
KT
L
V
W
C
DNE
W
GF
A
NRMLD
fig|358709.5.peg.1388
Escherichia coli 101-1 (1-328/339)
MTV
R
V
A
INGFGRIGR
N
V
V
R
A
L
Y
E
SG
R
R
A
EI
T
VVAIN
E
L
A
DA
AG
MA
H
LLKYD
T
SHGRF
A
W
E
V
RQER
D
Q
L
F
V
G
DD
A
IRV
L
H
E
H
SLQ
S
LPW
R
E
L
GVDVV
L
D
CTG
V
Y
G
S
R
E
HG
EAHI
A
AGAKKVL
F
S
H
P
G
S
N
D
LDA
T
V
VYGVN
Q
D
Q
L
R
A
E
H
R
IVSNASCTTNC
II
PV
I
K
L
LDDA
Y
GIE
S
GT
V
TTIH
S
A
M
H
D
Q
QV
I
D
A
-
Y
H
P
DLR
RT
RAASQ
S
IIP
VD
T
KL
A
AG
I
T
R
F
F
P
QF
N
DRF
E
A
I
A
V
RVPT
I
NV
TA
I
DL
S
V
T
V
K
K
P
V
K
A
N
EVN
L
L
L
Q
K
AA
Q
G
AFH
G
IV
D
YTE
LP
LVS
V
DFN
H
DPHS
AIV
D
G
TQ
-
--
T
R
V
S
G
AH
L
I
KT
L
V
W
C
DNE
W
GF
A
NRMLD
fig|585057.4.peg.3459
Escherichia coli IAI39 (1-328/339)
MTV
R
V
A
INGFGRIGR
N
V
V
R
A
L
Y
E
SG
R
R
A
EI
T
VVAIN
E
L
A
DA
AG
MA
H
LLKYD
T
SHGRF
A
W
E
V
RQER
D
Q
L
F
V
G
DD
A
IRV
L
H
E
H
SLQ
S
LPW
R
E
L
GVDVV
L
D
CTG
V
Y
G
S
R
E
HG
EAHI
A
AGAKKVL
F
S
H
P
G
S
N
D
LDA
T
V
VYGVN
Q
D
Q
L
R
A
E
H
R
IVSNASCTTNC
II
PV
I
K
L
LDDA
Y
GIE
S
GT
V
TTIH
S
A
M
H
D
Q
QV
I
D
A
-
Y
H
P
DLR
RT
RAASQ
S
IIP
VD
T
KL
A
AG
I
T
R
F
F
P
QF
N
DRF
E
A
I
A
V
RVPT
I
NV
TA
I
DL
S
V
T
V
K
K
P
V
K
A
N
EVN
L
L
L
Q
K
AA
Q
G
AFH
G
IV
D
YTE
LP
LVS
V
DFN
H
DPHS
AIV
D
G
TQ
-
--
T
R
V
S
G
AH
L
I
KT
L
V
W
C
DNE
W
GF
A
NRMLD
fig|585057.6.peg.3467
Escherichia coli IAI39 (1-328/339)
MTV
R
V
A
INGFGRIGR
N
V
V
R
A
L
Y
E
SG
R
R
A
EI
T
VVAIN
E
L
A
DA
AG
MA
H
LLKYD
T
SHGRF
A
W
E
V
RQER
D
Q
L
F
V
G
DD
A
IRV
L
H
E
H
SLQ
S
LPW
R
E
L
GVDVV
L
D
CTG
V
Y
G
S
R
E
HG
EAHI
A
AGAKKVL
F
S
H
P
G
S
N
D
LDA
T
V
VYGVN
Q
D
Q
L
R
A
E
H
R
IVSNASCTTNC
II
PV
I
K
L
LDDA
Y
GIE
S
GT
V
TTIH
S
A
M
H
D
Q
QV
I
D
A
-
Y
H
P
DLR
RT
RAASQ
S
IIP
VD
T
KL
A
AG
I
T
R
F
F
P
QF
N
DRF
E
A
I
A
V
RVPT
I
NV
TA
I
DL
S
V
T
V
K
K
P
V
K
A
N
EVN
L
L
L
Q
K
AA
Q
G
AFH
G
IV
D
YTE
LP
LVS
V
DFN
H
DPHS
AIV
D
G
TQ
-
--
T
R
V
S
G
AH
L
I
KT
L
V
W
C
DNE
W
GF
A
NRMLD
fig|749545.3.peg.3064
Escherichia coli MS 182-1 (1-328/339)
MTV
R
V
A
INGFGRIGR
N
V
V
R
A
L
Y
E
SG
R
R
A
EI
T
VVAIN
E
L
A
DA
AG
MA
H
LLKYD
T
SHGRF
A
W
E
V
RQER
D
Q
L
F
V
G
DD
A
IRV
L
H
E
H
SLQ
S
LPW
R
E
L
GVDVV
L
D
CTG
V
Y
G
S
R
E
HG
EAHI
A
AGAKKVL
F
S
H
P
G
S
N
D
LDA
T
V
VYGVN
Q
D
Q
L
R
A
E
H
R
IVSNASCTTNC
II
PV
I
K
L
LDDA
Y
GIE
S
GT
V
TTIH
S
A
M
H
D
Q
QV
I
D
A
-
Y
H
P
DLR
RT
RAASQ
S
IIP
VD
T
KL
A
AG
I
T
R
F
F
P
QF
N
DRF
E
A
I
A
V
RVPT
I
NV
TA
I
DL
S
V
T
V
K
K
P
V
K
A
N
EVN
L
L
L
Q
K
AA
Q
G
AFH
G
IV
D
YTE
LP
LVS
V
DFN
H
DPHS
AIV
D
G
TQ
-
--
T
R
V
S
G
AH
L
I
KT
L
V
W
C
DNE
W
GF
A
NRMLD
fig|656414.3.peg.3374
Escherichia coli H736 (1-328/339)
MTV
R
V
A
INGFGRIGR
N
V
V
R
A
L
Y
E
SG
R
R
A
EI
T
VVAIN
E
L
A
DA
AG
MA
H
LLKYD
T
SHGRF
A
W
E
V
RQER
D
Q
L
F
V
G
DD
A
I
G
V
L
H
ER
SLQ
S
LPW
R
E
L
GVDVV
L
D
CTG
V
Y
G
S
R
E
HG
EAHI
A
AGAKKVL
F
S
H
P
G
S
N
D
LDA
T
V
VYGVN
Q
D
Q
L
R
A
E
H
R
IVSNASCTTNC
II
PV
I
K
L
LDDA
Y
GIE
S
GT
V
TTIH
S
A
M
H
D
Q
QV
I
D
A
-
Y
H
P
DLR
RT
RAASQ
S
IIP
VD
T
KL
A
AG
I
T
R
F
F
P
QF
N
DRF
E
A
I
A
V
RVPT
I
NV
TA
I
DL
S
V
T
V
K
K
P
V
K
A
N
EVN
L
L
L
Q
K
AA
Q
G
AFH
G
IV
D
YTE
LP
LVS
V
DFN
H
DPHS
AIV
D
G
TQ
-
--
T
R
V
S
G
AH
L
I
KT
L
V
W
C
DNE
W
GF
A
NRMLD
Consen1
Primary consensus
MTvkVgINGFGRIGR
V
rrl
e
--
rseI
vVAINdL
da
mAylLKyDsshGrF
w
V
d
LiV
gk
IrV
aEr
nlpW
e
Gvdvv
ecTG
y
s
E
eaHi
AGAKKVl
s
P
-
s
d
t
VygvN
D
l
g
d
IVSnASCTTNClaPvaK
ldDafGIe
GtmTTiHa
t
tQ
vDgp
hkDlR
RaAsqnIIP
TgaAkaig
v
Pelngkl
g
A
RVPt
nvsv
dL
v
l
K
vtaeevn
alk
Aa
g
g
gYTe
lVS
Dfng
svfDatq
--
tav
d
lvKtv
WyDNE
Gf
nrmldliahisK
Consen2
Secondary consensus
ir
a
-
aa
qsg
ka
i
e
sp
l
hm
h
t
y
p
g
g
f
dd
a
h
k
sik
a
aeii
da
f
t
k
l
v
t
ga
e
m
kna
y
a
h
v
ii
i
i
y
i
lv
v
s
m
d
i
a
-
gp
w
g
aes
kl
agvt
f
qfsdrf
a
v
tgta
e
s
v
akynqik
lvq
t
n
-
d
d
iih
aiv
gka
eiirl
g
fi
ll
c
y
t
irtlekfa
Consensus 1
(when a gap)
Conservative difference
Consensus 2
(when a gap)
Nonconservative diff.
Other character