fig|1040638.4.peg.3798
Escherichia coli O104:H4 str. LB226692
MSQK
L
KVV
T
IGGGS
S
Y
TP
EL
L
E
G
F
I
KRYHE
LP
VSE
L
W
L
V
D
V
E
DG
K
EKLDI
I
FEL
CQ
R
M
I
D
N
AG
VPM
K
LYK
T
L
D
R
REAL
K
DADFV
TTQL
RVG
Q
L
-
P
A
RELDERIPL
S
HG
Y
LGQ
---
ET
N
G
A
GG
L
FK
GLRTIP
V
I
F
D
IVKD
V
EE
L
CPNAW
VI
N
F
T
NPA
G
MVTEA
V
YR
HT
G
FK
R
F
IG
V
C
N
I
PIG
MKMF
I
R
DV
L
M
L
K
D
SDD
L
S
I
D
LF
GLNHM
---VF
I
K
D
VLVN
G
K
--
S
R
F
A
ELL
DG
V
A
--------------
-
---S
GQ
L
KA
SS
V
KNI
FDLPFSEGLIR
SL
N
L
LP
C
SYL
L
YY
F
K
Q
K
E
-
MLAI
E
MG
E
Y
YK
G
GARAQ
V
V
Q
KV
EKQLFE
L
YK
N
P
----------
E
L
KVKP
KELE
QRGG
A
YYS
D
A
------
AC
EV
INAI
Y
N
--------
D
K
Q
A
EH
YVN
----------------
I
P
H
HG
H
IDN
I
P
ADWA
VEM
T
C
K
L
G
R
D
G
AT
P
H
P
----
R
I
TH
F
DDKVM
GL
I
H
T
IKG
F
E
I
A
AS
NA
A
L
SGEFND
V
LL
A
LN
LSP
---
L
V
H
S
DRD
A
E
L
L
A
R
E
M
I
L
AH
EK
WLP
NF
ADCIAELKKAH
fig|6666666.5357.peg.1221
Escherichia coli TY-2482
MSQK
L
KVV
T
IGGGS
S
Y
TP
EL
L
E
G
F
I
KRYHE
LP
VSE
L
W
L
V
D
V
E
DG
K
EKLDI
I
FEL
CQ
R
M
I
D
N
AG
VPM
K
LYK
T
L
D
R
REAL
K
DADFV
TTQL
RVG
Q
L
-
P
A
RELDERIPL
S
HG
Y
LGQ
---
ET
N
G
A
GG
L
FK
GLRTIP
V
I
F
D
IVKD
V
EE
L
CPNAW
VI
N
F
T
NPA
G
MVTEA
V
YR
HT
G
FK
R
F
IG
V
C
N
I
PIG
MKMF
I
R
DV
L
M
L
K
D
SDD
L
S
I
D
LF
GLNHM
---VF
I
K
D
VLVN
G
K
--
S
R
F
A
ELL
DG
V
A
--------------
-
---S
GQ
L
KA
SS
V
KNI
FDLPFSEGLIR
SL
N
L
LP
C
SYL
L
YY
F
K
Q
K
E
-
MLAI
E
MG
E
Y
YK
G
GARAQ
V
V
Q
KV
EKQLFE
L
YK
N
P
----------
E
L
KVKP
KELE
QRGG
A
YYS
D
A
------
AC
EV
INAI
Y
N
--------
D
K
Q
A
EH
YVN
----------------
I
P
H
HG
H
IDN
I
P
ADWA
VEM
T
C
K
L
G
R
D
G
AT
P
H
P
----
R
I
TH
F
DDKVM
GL
I
H
T
IKG
F
E
I
A
AS
NA
A
L
SGEFND
V
LL
A
LN
LSP
---
L
V
H
S
DRD
A
E
L
L
A
R
E
M
I
L
AH
EK
WLP
NF
ADCIAELKKAH
fig|585055.6.peg.1931
Escherichia coli 55989
MSQK
L
KVV
T
IGGGS
S
Y
TP
EL
L
E
G
F
I
KRYHE
LP
VSE
L
W
L
V
D
V
E
DG
K
EKLDI
I
FEL
CQ
R
M
I
D
N
AG
VPM
K
LYK
T
L
D
R
REAL
K
DADFV
TTQL
RVG
Q
L
-
P
A
RELDERIPL
S
HG
Y
LGQ
---
ET
N
G
A
GG
L
FK
GLRTIP
V
I
F
D
IVKD
V
EE
L
CPNAW
VI
N
F
T
NPA
G
MVTEA
V
YR
HT
G
FK
R
F
IG
V
C
N
I
PIG
MKMF
I
R
DV
L
M
L
K
D
SDD
L
S
I
D
LF
GLNHM
---VF
I
K
D
VLVN
G
K
--
S
R
F
A
ELL
DG
V
A
--------------
-
---S
GQ
L
KA
SS
V
KNI
FDLPFSEGLIR
SL
N
L
LP
C
SYL
L
YY
F
K
Q
K
E
-
MLAI
E
MG
E
Y
YK
G
GARAQ
V
V
Q
KV
EKQLFE
L
YK
N
P
----------
E
L
KVKP
KELE
QRGG
A
YYS
D
A
------
AC
EV
INAI
Y
N
--------
D
K
Q
A
EH
YVN
----------------
I
P
H
HG
H
IDN
I
P
ADWA
VEM
T
C
K
L
G
R
D
G
AT
P
H
P
----
R
I
TH
F
DDKVM
GL
I
H
T
IKG
F
E
I
A
AS
NA
A
L
SGEFND
V
LL
A
LN
LSP
---
L
V
H
S
DRD
A
E
L
L
A
R
E
M
I
L
AH
EK
WLP
NF
ADCIAELKKAH
fig|585055.8.peg.1934
Escherichia coli 55989
MSQK
L
KVV
T
IGGGS
S
Y
TP
EL
L
E
G
F
I
KRYHE
LP
VSE
L
W
L
V
D
V
E
DG
K
EKLDI
I
FEL
CQ
R
M
I
D
N
AG
VPM
K
LYK
T
L
D
R
REAL
K
DADFV
TTQL
RVG
Q
L
-
P
A
RELDERIPL
S
HG
Y
LGQ
---
ET
N
G
A
GG
L
FK
GLRTIP
V
I
F
D
IVKD
V
EE
L
CPNAW
VI
N
F
T
NPA
G
MVTEA
V
YR
HT
G
FK
R
F
IG
V
C
N
I
PIG
MKMF
I
R
DV
L
M
L
K
D
SDD
L
S
I
D
LF
GLNHM
---VF
I
K
D
VLVN
G
K
--
S
R
F
A
ELL
DG
V
A
--------------
-
---S
GQ
L
KA
SS
V
KNI
FDLPFSEGLIR
SL
N
L
LP
C
SYL
L
YY
F
K
Q
K
E
-
MLAI
E
MG
E
Y
YK
G
GARAQ
V
V
Q
KV
EKQLFE
L
YK
N
P
----------
E
L
KVKP
KELE
QRGG
A
YYS
D
A
------
AC
EV
INAI
Y
N
--------
D
K
Q
A
EH
YVN
----------------
I
P
H
HG
H
IDN
I
P
ADWA
VEM
T
C
K
L
G
R
D
G
AT
P
H
P
----
R
I
TH
F
DDKVM
GL
I
H
T
IKG
F
E
I
A
AS
NA
A
L
SGEFND
V
LL
A
LN
LSP
---
L
V
H
S
DRD
A
E
L
L
A
R
E
M
I
L
AH
EK
WLP
NF
ADCIAELKKAH
fig|550672.3.peg.2583
Escherichia coli B088
MSQK
L
KVV
T
IGGGS
S
Y
TP
EL
L
E
G
F
I
KRYHE
LP
VSE
L
W
L
V
D
V
E
DG
K
EKLDI
I
FEL
CQ
R
M
I
D
N
AG
VPM
K
LYK
T
L
D
R
REAL
K
DADFV
TTQL
RVG
Q
L
-
P
A
RELDERIPL
S
HG
Y
LGQ
---
ET
N
G
A
GG
L
FK
GLRTIP
V
I
F
D
IVKD
V
EE
L
CPNAW
VI
N
F
T
NPA
G
MVTEA
V
YR
HT
G
FK
R
F
IG
V
C
N
I
PIG
MKMF
I
R
DV
L
M
L
K
D
SDD
L
S
I
D
LF
GLNHM
---VF
I
K
D
VLVN
G
K
--
S
R
F
A
ELL
DG
V
A
--------------
-
---S
GQ
L
KA
SS
V
KNI
FDLPFSEGLIR
SL
N
L
LP
C
SYL
L
YY
F
K
Q
K
E
-
MLAI
E
MG
E
Y
YK
G
GARAQ
V
V
Q
KV
EKQLFE
L
YK
N
P
----------
E
L
KVKP
KELE
QRGG
A
YYS
D
A
------
AC
EV
INAI
Y
N
--------
D
K
Q
A
EH
YVN
----------------
I
P
H
HG
H
IDN
I
P
ADWA
VEM
T
C
K
L
G
R
D
G
AT
P
H
P
----
R
I
TH
F
DDKVM
GL
I
H
T
IKG
F
E
I
A
AS
NA
A
L
SGEFND
V
LL
A
LN
LSP
---
L
V
H
S
DRD
A
E
L
L
A
R
E
M
I
L
AH
EK
WLP
NF
ADCIAELKKAH
fig|344601.3.peg.2853
Escherichia coli B171
MSQK
L
KVV
T
IGGGS
S
Y
TP
EL
L
E
G
F
I
KRYHE
LP
VSE
L
W
L
V
D
V
E
DG
K
EKLDI
I
FEL
CQ
R
M
I
D
N
AG
VPM
K
LYK
T
L
D
R
REAL
K
DADFV
TTQL
RVG
Q
L
-
P
A
RELDERIPL
S
HG
Y
LGQ
---
ET
N
G
A
GG
L
FK
GLRTIP
V
I
F
D
IVKD
V
EE
L
CPNAW
VI
N
F
T
NPA
G
MVTEA
V
YR
HT
G
FK
R
F
IG
V
C
N
I
PIG
MKMF
I
R
DV
L
M
L
K
D
SDD
L
S
I
D
LF
GLNHM
---VF
I
K
D
VLVN
G
K
--
S
R
F
A
ELL
DG
V
A
--------------
-
---S
GQ
L
KA
SS
V
KNI
FDLPFSEGLIR
SL
N
L
LP
C
SYL
L
YY
F
K
Q
K
E
-
MLAI
E
MG
E
Y
YK
G
GARAQ
V
V
Q
KV
EKQLFE
L
YK
N
P
----------
E
L
KVKP
KELE
QRGG
A
YYS
D
A
------
AC
EV
INAI
Y
N
--------
D
K
Q
A
EH
YVN
----------------
I
P
H
HG
H
IDN
I
P
ADWA
VEM
T
C
K
L
G
R
D
G
AT
P
H
P
----
R
I
TH
F
DDKVM
GL
I
H
T
IKG
F
E
I
A
AS
NA
A
L
SGEFND
V
LL
A
LN
LSP
---
L
V
H
S
DRD
A
E
L
L
A
R
E
M
I
L
AH
EK
WLP
NF
ADCIAELKKAH
fig|344601.5.peg.2972
Escherichia coli B171
MSQK
L
KVV
T
IGGGS
S
Y
TP
EL
L
E
G
F
I
KRYHE
LP
VSE
L
W
L
V
D
V
E
DG
K
EKLDI
I
FEL
CQ
R
M
I
D
N
AG
VPM
K
LYK
T
L
D
R
REAL
K
DADFV
TTQL
RVG
Q
L
-
P
A
RELDERIPL
S
HG
Y
LGQ
---
ET
N
G
A
GG
L
FK
GLRTIP
V
I
F
D
IVKD
V
EE
L
CPNAW
VI
N
F
T
NPA
G
MVTEA
V
YR
HT
G
FK
R
F
IG
V
C
N
I
PIG
MKMF
I
R
DV
L
M
L
K
D
SDD
L
S
I
D
LF
GLNHM
---VF
I
K
D
VLVN
G
K
--
S
R
F
A
ELL
DG
V
A
--------------
-
---S
GQ
L
KA
SS
V
KNI
FDLPFSEGLIR
SL
N
L
LP
C
SYL
L
YY
F
K
Q
K
E
-
MLAI
E
MG
E
Y
YK
G
GARAQ
V
V
Q
KV
EKQLFE
L
YK
N
P
----------
E
L
KVKP
KELE
QRGG
A
YYS
D
A
------
AC
EV
INAI
Y
N
--------
D
K
Q
A
EH
YVN
----------------
I
P
H
HG
H
IDN
I
P
ADWA
VEM
T
C
K
L
G
R
D
G
AT
P
H
P
----
R
I
TH
F
DDKVM
GL
I
H
T
IKG
F
E
I
A
AS
NA
A
L
SGEFND
V
LL
A
LN
LSP
---
L
V
H
S
DRD
A
E
L
L
A
R
E
M
I
L
AH
EK
WLP
NF
ADCIAELKKAH
fig|340184.3.peg.4140
Escherichia coli B7A
MSQK
L
KVV
T
IGGGS
S
Y
TP
EL
L
E
G
F
I
KRYHE
LP
VSE
L
W
L
V
D
V
E
DG
K
EKLDI
I
FEL
CQ
R
M
I
D
N
AG
VPM
K
LYK
T
L
D
R
REAL
K
DADFV
TTQL
RVG
Q
L
-
P
A
RELDERIPL
S
HG
Y
LGQ
---
ET
N
G
A
GG
L
FK
GLRTIP
V
I
F
D
IVKD
V
EE
L
CPNAW
VI
N
F
T
NPA
G
MVTEA
V
YR
HT
G
FK
R
F
IG
V
C
N
I
PIG
MKMF
I
R
DV
L
M
L
K
D
SDD
L
S
I
D
LF
GLNHM
---VF
I
K
D
VLVN
G
K
--
S
R
F
A
ELL
DG
V
A
--------------
-
---S
GQ
L
KA
SS
V
KNI
FDLPFSEGLIR
SL
N
L
LP
C
SYL
L
YY
F
K
Q
K
E
-
MLAI
E
MG
E
Y
YK
G
GARAQ
V
V
Q
KV
EKQLFE
L
YK
N
P
----------
E
L
KVKP
KELE
QRGG
A
YYS
D
A
------
AC
EV
INAI
Y
N
--------
D
K
Q
A
EH
YVN
----------------
I
P
H
HG
H
IDN
I
P
ADWA
VEM
T
C
K
L
G
R
D
G
AT
P
H
P
----
R
I
TH
F
DDKVM
GL
I
H
T
IKG
F
E
I
A
AS
NA
A
L
SGEFND
V
LL
A
LN
LSP
---
L
V
H
S
DRD
A
E
L
L
A
R
E
M
I
L
AH
EK
WLP
NF
ADCIAELKKAH
fig|340184.6.peg.4336
Escherichia coli B7A
MSQK
L
KVV
T
IGGGS
S
Y
TP
EL
L
E
G
F
I
KRYHE
LP
VSE
L
W
L
V
D
V
E
DG
K
EKLDI
I
FEL
CQ
R
M
I
D
N
AG
VPM
K
LYK
T
L
D
R
REAL
K
DADFV
TTQL
RVG
Q
L
-
P
A
RELDERIPL
S
HG
Y
LGQ
---
ET
N
G
A
GG
L
FK
GLRTIP
V
I
F
D
IVKD
V
EE
L
CPNAW
VI
N
F
T
NPA
G
MVTEA
V
YR
HT
G
FK
R
F
IG
V
C
N
I
PIG
MKMF
I
R
DV
L
M
L
K
D
SDD
L
S
I
D
LF
GLNHM
---VF
I
K
D
VLVN
G
K
--
S
R
F
A
ELL
DG
V
A
--------------
-
---S
GQ
L
KA
SS
V
KNI
FDLPFSEGLIR
SL
N
L
LP
C
SYL
L
YY
F
K
Q
K
E
-
MLAI
E
MG
E
Y
YK
G
GARAQ
V
V
Q
KV
EKQLFE
L
YK
N
P
----------
E
L
KVKP
KELE
QRGG
A
YYS
D
A
------
AC
EV
INAI
Y
N
--------
D
K
Q
A
EH
YVN
----------------
I
P
H
HG
H
IDN
I
P
ADWA
VEM
T
C
K
L
G
R
D
G
AT
P
H
P
----
R
I
TH
F
DDKVM
GL
I
H
T
IKG
F
E
I
A
AS
NA
A
L
SGEFND
V
LL
A
LN
LSP
---
L
V
H
S
DRD
A
E
L
L
A
R
E
M
I
L
AH
EK
WLP
NF
ADCIAELKKAH
fig|340186.3.peg.2131
Escherichia coli E110019
MSQK
L
KVV
T
IGGGS
S
Y
TP
EL
L
E
G
F
I
KRYHE
LP
VSE
L
W
L
V
D
V
E
DG
K
EKLDI
I
FEL
CQ
R
M
I
D
N
AG
VPM
K
LYK
T
L
D
R
REAL
K
DADFV
TTQL
RVG
Q
L
-
P
A
RELDERIPL
S
HG
Y
LGQ
---
ET
N
G
A
GG
L
FK
GLRTIP
V
I
F
D
IVKD
V
EE
L
CPNAW
VI
N
F
T
NPA
G
MVTEA
V
YR
HT
G
FK
R
F
IG
V
C
N
I
PIG
MKMF
I
R
DV
L
M
L
K
D
SDD
L
S
I
D
LF
GLNHM
---VF
I
K
D
VLVN
G
K
--
S
R
F
A
ELL
DG
V
A
--------------
-
---S
GQ
L
KA
SS
V
KNI
FDLPFSEGLIR
SL
N
L
LP
C
SYL
L
YY
F
K
Q
K
E
-
MLAI
E
MG
E
Y
YK
G
GARAQ
V
V
Q
KV
EKQLFE
L
YK
N
P
----------
E
L
KVKP
KELE
QRGG
A
YYS
D
A
------
AC
EV
INAI
Y
N
--------
D
K
Q
A
EH
YVN
----------------
I
P
H
HG
H
IDN
I
P
ADWA
VEM
T
C
K
L
G
R
D
G
AT
P
H
P
----
R
I
TH
F
DDKVM
GL
I
H
T
IKG
F
E
I
A
AS
NA
A
L
SGEFND
V
LL
A
LN
LSP
---
L
V
H
S
DRD
A
E
L
L
A
R
E
M
I
L
AH
EK
WLP
NF
ADCIAELKKAH
fig|340186.5.peg.2196
Escherichia coli E110019
MSQK
L
KVV
T
IGGGS
S
Y
TP
EL
L
E
G
F
I
KRYHE
LP
VSE
L
W
L
V
D
V
E
DG
K
EKLDI
I
FEL
CQ
R
M
I
D
N
AG
VPM
K
LYK
T
L
D
R
REAL
K
DADFV
TTQL
RVG
Q
L
-
P
A
RELDERIPL
S
HG
Y
LGQ
---
ET
N
G
A
GG
L
FK
GLRTIP
V
I
F
D
IVKD
V
EE
L
CPNAW
VI
N
F
T
NPA
G
MVTEA
V
YR
HT
G
FK
R
F
IG
V
C
N
I
PIG
MKMF
I
R
DV
L
M
L
K
D
SDD
L
S
I
D
LF
GLNHM
---VF
I
K
D
VLVN
G
K
--
S
R
F
A
ELL
DG
V
A
--------------
-
---S
GQ
L
KA
SS
V
KNI
FDLPFSEGLIR
SL
N
L
LP
C
SYL
L
YY
F
K
Q
K
E
-
MLAI
E
MG
E
Y
YK
G
GARAQ
V
V
Q
KV
EKQLFE
L
YK
N
P
----------
E
L
KVKP
KELE
QRGG
A
YYS
D
A
------
AC
EV
INAI
Y
N
--------
D
K
Q
A
EH
YVN
----------------
I
P
H
HG
H
IDN
I
P
ADWA
VEM
T
C
K
L
G
R
D
G
AT
P
H
P
----
R
I
TH
F
DDKVM
GL
I
H
T
IKG
F
E
I
A
AS
NA
A
L
SGEFND
V
LL
A
LN
LSP
---
L
V
H
S
DRD
A
E
L
L
A
R
E
M
I
L
AH
EK
WLP
NF
ADCIAELKKAH
fig|340185.3.peg.4162
Escherichia coli E22
MSQK
L
KVV
T
IGGGS
S
Y
TP
EL
L
E
G
F
I
KRYHE
LP
VSE
L
W
L
V
D
V
E
DG
K
EKLDI
I
FEL
CQ
R
M
I
D
N
AG
VPM
K
LYK
T
L
D
R
REAL
K
DADFV
TTQL
RVG
Q
L
-
P
A
RELDERIPL
S
HG
Y
LGQ
---
ET
N
G
A
GG
L
FK
GLRTIP
V
I
F
D
IVKD
V
EE
L
CPNAW
VI
N
F
T
NPA
G
MVTEA
V
YR
HT
G
FK
R
F
IG
V
C
N
I
PIG
MKMF
I
R
DV
L
M
L
K
D
SDD
L
S
I
D
LF
GLNHM
---VF
I
K
D
VLVN
G
K
--
S
R
F
A
ELL
DG
V
A
--------------
-
---S
GQ
L
KA
SS
V
KNI
FDLPFSEGLIR
SL
N
L
LP
C
SYL
L
YY
F
K
Q
K
E
-
MLAI
E
MG
E
Y
YK
G
GARAQ
V
V
Q
KV
EKQLFE
L
YK
N
P
----------
E
L
KVKP
KELE
QRGG
A
YYS
D
A
------
AC
EV
INAI
Y
N
--------
D
K
Q
A
EH
YVN
----------------
I
P
H
HG
H
IDN
I
P
ADWA
VEM
T
C
K
L
G
R
D
G
AT
P
H
P
----
R
I
TH
F
DDKVM
GL
I
H
T
IKG
F
E
I
A
AS
NA
A
L
SGEFND
V
LL
A
LN
LSP
---
L
V
H
S
DRD
A
E
L
L
A
R
E
M
I
L
AH
EK
WLP
NF
ADCIAELKKAH
fig|340185.4.peg.4390
Escherichia coli E22
MSQK
L
KVV
T
IGGGS
S
Y
TP
EL
L
E
G
F
I
KRYHE
LP
VSE
L
W
L
V
D
V
E
DG
K
EKLDI
I
FEL
CQ
R
M
I
D
N
AG
VPM
K
LYK
T
L
D
R
REAL
K
DADFV
TTQL
RVG
Q
L
-
P
A
RELDERIPL
S
HG
Y
LGQ
---
ET
N
G
A
GG
L
FK
GLRTIP
V
I
F
D
IVKD
V
EE
L
CPNAW
VI
N
F
T
NPA
G
MVTEA
V
YR
HT
G
FK
R
F
IG
V
C
N
I
PIG
MKMF
I
R
DV
L
M
L
K
D
SDD
L
S
I
D
LF
GLNHM
---VF
I
K
D
VLVN
G
K
--
S
R
F
A
ELL
DG
V
A
--------------
-
---S
GQ
L
KA
SS
V
KNI
FDLPFSEGLIR
SL
N
L
LP
C
SYL
L
YY
F
K
Q
K
E
-
MLAI
E
MG
E
Y
YK
G
GARAQ
V
V
Q
KV
EKQLFE
L
YK
N
P
----------
E
L
KVKP
KELE
QRGG
A
YYS
D
A
------
AC
EV
INAI
Y
N
--------
D
K
Q
A
EH
YVN
----------------
I
P
H
HG
H
IDN
I
P
ADWA
VEM
T
C
K
L
G
R
D
G
AT
P
H
P
----
R
I
TH
F
DDKVM
GL
I
H
T
IKG
F
E
I
A
AS
NA
A
L
SGEFND
V
LL
A
LN
LSP
---
L
V
H
S
DRD
A
E
L
L
A
R
E
M
I
L
AH
EK
WLP
NF
ADCIAELKKAH
fig|331111.12.peg.2232
Escherichia coli E24377A
MSQK
L
KVV
T
IGGGS
S
Y
TP
EL
L
E
G
F
I
KRYHE
LP
VSE
L
W
L
V
D
V
E
DG
K
EKLDI
I
FEL
CQ
R
M
I
D
N
AG
VPM
K
LYK
T
L
D
R
REAL
K
DADFV
TTQL
RVG
Q
L
-
P
A
RELDERIPL
S
HG
Y
LGQ
---
ET
N
G
A
GG
L
FK
GLRTIP
V
I
F
D
IVKD
V
EE
L
CPNAW
VI
N
F
T
NPA
G
MVTEA
V
YR
HT
G
FK
R
F
IG
V
C
N
I
PIG
MKMF
I
R
DV
L
M
L
K
D
SDD
L
S
I
D
LF
GLNHM
---VF
I
K
D
VLVN
G
K
--
S
R
F
A
ELL
DG
V
A
--------------
-
---S
GQ
L
KA
SS
V
KNI
FDLPFSEGLIR
SL
N
L
LP
C
SYL
L
YY
F
K
Q
K
E
-
MLAI
E
MG
E
Y
YK
G
GARAQ
V
V
Q
KV
EKQLFE
L
YK
N
P
----------
E
L
KVKP
KELE
QRGG
A
YYS
D
A
------
AC
EV
INAI
Y
N
--------
D
K
Q
A
EH
YVN
----------------
I
P
H
HG
H
IDN
I
P
ADWA
VEM
T
C
K
L
G
R
D
G
AT
P
H
P
----
R
I
TH
F
DDKVM
GL
I
H
T
IKG
F
E
I
A
AS
NA
A
L
SGEFND
V
LL
A
LN
LSP
---
L
V
H
S
DRD
A
E
L
L
A
R
E
M
I
L
AH
EK
WLP
NF
ADCIAELKKAH
fig|331111.3.peg.4376
Escherichia coli E24377A
MSQK
L
KVV
T
IGGGS
S
Y
TP
EL
L
E
G
F
I
KRYHE
LP
VSE
L
W
L
V
D
V
E
DG
K
EKLDI
I
FEL
CQ
R
M
I
D
N
AG
VPM
K
LYK
T
L
D
R
REAL
K
DADFV
TTQL
RVG
Q
L
-
P
A
RELDERIPL
S
HG
Y
LGQ
---
ET
N
G
A
GG
L
FK
GLRTIP
V
I
F
D
IVKD
V
EE
L
CPNAW
VI
N
F
T
NPA
G
MVTEA
V
YR
HT
G
FK
R
F
IG
V
C
N
I
PIG
MKMF
I
R
DV
L
M
L
K
D
SDD
L
S
I
D
LF
GLNHM
---VF
I
K
D
VLVN
G
K
--
S
R
F
A
ELL
DG
V
A
--------------
-
---S
GQ
L
KA
SS
V
KNI
FDLPFSEGLIR
SL
N
L
LP
C
SYL
L
YY
F
K
Q
K
E
-
MLAI
E
MG
E
Y
YK
G
GARAQ
V
V
Q
KV
EKQLFE
L
YK
N
P
----------
E
L
KVKP
KELE
QRGG
A
YYS
D
A
------
AC
EV
INAI
Y
N
--------
D
K
Q
A
EH
YVN
----------------
I
P
H
HG
H
IDN
I
P
ADWA
VEM
T
C
K
L
G
R
D
G
AT
P
H
P
----
R
I
TH
F
DDKVM
GL
I
H
T
IKG
F
E
I
A
AS
NA
A
L
SGEFND
V
LL
A
LN
LSP
---
L
V
H
S
DRD
A
E
L
L
A
R
E
M
I
L
AH
EK
WLP
NF
ADCIAELKKAH
fig|562.375.peg.1849
Escherichia coli EC4100B
MSQK
L
KVV
T
IGGGS
S
Y
TP
EL
L
E
G
F
I
KRYHE
LP
VSE
L
W
L
V
D
V
E
DG
K
EKLDI
I
FEL
CQ
R
M
I
D
N
AG
VPM
K
LYK
T
L
D
R
REAL
K
DADFV
TTQL
RVG
Q
L
-
P
A
RELDERIPL
S
HG
Y
LGQ
---
ET
N
G
A
GG
L
FK
GLRTIP
V
I
F
D
IVKD
V
EE
L
CPNAW
VI
N
F
T
NPA
G
MVTEA
V
YR
HT
G
FK
R
F
IG
V
C
N
I
PIG
MKMF
I
R
DV
L
M
L
K
D
SDD
L
S
I
D
LF
GLNHM
---VF
I
K
D
VLVN
G
K
--
S
R
F
A
ELL
DG
V
A
--------------
-
---S
GQ
L
KA
SS
V
KNI
FDLPFSEGLIR
SL
N
L
LP
C
SYL
L
YY
F
K
Q
K
E
-
MLAI
E
MG
E
Y
YK
G
GARAQ
V
V
Q
KV
EKQLFE
L
YK
N
P
----------
E
L
KVKP
KELE
QRGG
A
YYS
D
A
------
AC
EV
INAI
Y
N
--------
D
K
Q
A
EH
YVN
----------------
I
P
H
HG
H
IDN
I
P
ADWA
VEM
T
C
K
L
G
R
D
G
AT
P
H
P
----
R
I
TH
F
DDKVM
GL
I
H
T
IKG
F
E
I
A
AS
NA
A
L
SGEFND
V
LL
A
LN
LSP
---
L
V
H
S
DRD
A
E
L
L
A
R
E
M
I
L
AH
EK
WLP
NF
ADCIAELKKAH
fig|656408.3.peg.1895
Escherichia coli H591
MSQK
L
KVV
T
IGGGS
S
Y
TP
EL
L
E
G
F
I
KRYHE
LP
VSE
L
W
L
V
D
V
E
DG
K
EKLDI
I
FEL
CQ
R
M
I
D
N
AG
VPM
K
LYK
T
L
D
R
REAL
K
DADFV
TTQL
RVG
Q
L
-
P
A
RELDERIPL
S
HG
Y
LGQ
---
ET
N
G
A
GG
L
FK
GLRTIP
V
I
F
D
IVKD
V
EE
L
CPNAW
VI
N
F
T
NPA
G
MVTEA
V
YR
HT
G
FK
R
F
IG
V
C
N
I
PIG
MKMF
I
R
DV
L
M
L
K
D
SDD
L
S
I
D
LF
GLNHM
---VF
I
K
D
VLVN
G
K
--
S
R
F
A
ELL
DG
V
A
--------------
-
---S
GQ
L
KA
SS
V
KNI
FDLPFSEGLIR
SL
N
L
LP
C
SYL
L
YY
F
K
Q
K
E
-
MLAI
E
MG
E
Y
YK
G
GARAQ
V
V
Q
KV
EKQLFE
L
YK
N
P
----------
E
L
KVKP
KELE
QRGG
A
YYS
D
A
------
AC
EV
INAI
Y
N
--------
D
K
Q
A
EH
YVN
----------------
I
P
H
HG
H
IDN
I
P
ADWA
VEM
T
C
K
L
G
R
D
G
AT
P
H
P
----
R
I
TH
F
DDKVM
GL
I
H
T
IKG
F
E
I
A
AS
NA
A
L
SGEFND
V
LL
A
LN
LSP
---
L
V
H
S
DRD
A
E
L
L
A
R
E
M
I
L
AH
EK
WLP
NF
ADCIAELKKAH
fig|585034.4.peg.1772
Escherichia coli IAI1
MSQK
L
KVV
T
IGGGS
S
Y
TP
EL
L
E
G
F
I
KRYHE
LP
VSE
L
W
L
V
D
V
E
DG
K
EKLDI
I
FEL
CQ
R
M
I
D
N
AG
VPM
K
LYK
T
L
D
R
REAL
K
DADFV
TTQL
RVG
Q
L
-
P
A
RELDERIPL
S
HG
Y
LGQ
---
ET
N
G
A
GG
L
FK
GLRTIP
V
I
F
D
IVKD
V
EE
L
CPNAW
VI
N
F
T
NPA
G
MVTEA
V
YR
HT
G
FK
R
F
IG
V
C
N
I
PIG
MKMF
I
R
DV
L
M
L
K
D
SDD
L
S
I
D
LF
GLNHM
---VF
I
K
D
VLVN
G
K
--
S
R
F
A
ELL
DG
V
A
--------------
-
---S
GQ
L
KA
SS
V
KNI
FDLPFSEGLIR
SL
N
L
LP
C
SYL
L
YY
F
K
Q
K
E
-
MLAI
E
MG
E
Y
YK
G
GARAQ
V
V
Q
KV
EKQLFE
L
YK
N
P
----------
E
L
KVKP
KELE
QRGG
A
YYS
D
A
------
AC
EV
INAI
Y
N
--------
D
K
Q
A
EH
YVN
----------------
I
P
H
HG
H
IDN
I
P
ADWA
VEM
T
C
K
L
G
R
D
G
AT
P
H
P
----
R
I
TH
F
DDKVM
GL
I
H
T
IKG
F
E
I
A
AS
NA
A
L
SGEFND
V
LL
A
LN
LSP
---
L
V
H
S
DRD
A
E
L
L
A
R
E
M
I
L
AH
EK
WLP
NF
ADCIAELKKAH
fig|585034.5.peg.1767
Escherichia coli IAI1
MSQK
L
KVV
T
IGGGS
S
Y
TP
EL
L
E
G
F
I
KRYHE
LP
VSE
L
W
L
V
D
V
E
DG
K
EKLDI
I
FEL
CQ
R
M
I
D
N
AG
VPM
K
LYK
T
L
D
R
REAL
K
DADFV
TTQL
RVG
Q
L
-
P
A
RELDERIPL
S
HG
Y
LGQ
---
ET
N
G
A
GG
L
FK
GLRTIP
V
I
F
D
IVKD
V
EE
L
CPNAW
VI
N
F
T
NPA
G
MVTEA
V
YR
HT
G
FK
R
F
IG
V
C
N
I
PIG
MKMF
I
R
DV
L
M
L
K
D
SDD
L
S
I
D
LF
GLNHM
---VF
I
K
D
VLVN
G
K
--
S
R
F
A
ELL
DG
V
A
--------------
-
---S
GQ
L
KA
SS
V
KNI
FDLPFSEGLIR
SL
N
L
LP
C
SYL
L
YY
F
K
Q
K
E
-
MLAI
E
MG
E
Y
YK
G
GARAQ
V
V
Q
KV
EKQLFE
L
YK
N
P
----------
E
L
KVKP
KELE
QRGG
A
YYS
D
A
------
AC
EV
INAI
Y
N
--------
D
K
Q
A
EH
YVN
----------------
I
P
H
HG
H
IDN
I
P
ADWA
VEM
T
C
K
L
G
R
D
G
AT
P
H
P
----
R
I
TH
F
DDKVM
GL
I
H
T
IKG
F
E
I
A
AS
NA
A
L
SGEFND
V
LL
A
LN
LSP
---
L
V
H
S
DRD
A
E
L
L
A
R
E
M
I
L
AH
EK
WLP
NF
ADCIAELKKAH
fig|679207.4.peg.3327
Escherichia coli MS 107-1
MSQK
L
KVV
T
IGGGS
S
Y
TP
EL
L
E
G
F
I
KRYHE
LP
VSE
L
W
L
V
D
V
E
DG
K
EKLDI
I
FEL
CQ
R
M
I
D
N
AG
VPM
K
LYK
T
L
D
R
REAL
K
DADFV
TTQL
RVG
Q
L
-
P
A
RELDERIPL
S
HG
Y
LGQ
---
ET
N
G
A
GG
L
FK
GLRTIP
V
I
F
D
IVKD
V
EE
L
CPNAW
VI
N
F
T
NPA
G
MVTEA
V
YR
HT
G
FK
R
F
IG
V
C
N
I
PIG
MKMF
I
R
DV
L
M
L
K
D
SDD
L
S
I
D
LF
GLNHM
---VF
I
K
D
VLVN
G
K
--
S
R
F
A
ELL
DG
V
A
--------------
-
---S
GQ
L
KA
SS
V
KNI
FDLPFSEGLIR
SL
N
L
LP
C
SYL
L
YY
F
K
Q
K
E
-
MLAI
E
MG
E
Y
YK
G
GARAQ
V
V
Q
KV
EKQLFE
L
YK
N
P
----------
E
L
KVKP
KELE
QRGG
A
YYS
D
A
------
AC
EV
INAI
Y
N
--------
D
K
Q
A
EH
YVN
----------------
I
P
H
HG
H
IDN
I
P
ADWA
VEM
T
C
K
L
G
R
D
G
AT
P
H
P
----
R
I
TH
F
DDKVM
GL
I
H
T
IKG
F
E
I
A
AS
NA
A
L
SGEFND
V
LL
A
LN
LSP
---
L
V
H
S
DRD
A
E
L
L
A
R
E
M
I
L
AH
EK
WLP
NF
ADCIAELKKAH
fig|679206.4.peg.1155
Escherichia coli MS 119-7
MSQK
L
KVV
T
IGGGS
S
Y
TP
EL
L
E
G
F
I
KRYHE
LP
VSE
L
W
L
V
D
V
E
DG
K
EKLDI
I
FEL
CQ
R
M
I
D
N
AG
VPM
K
LYK
T
L
D
R
REAL
K
DADFV
TTQL
RVG
Q
L
-
P
A
RELDERIPL
S
HG
Y
LGQ
---
ET
N
G
A
GG
L
FK
GLRTIP
V
I
F
D
IVKD
V
EE
L
CPNAW
VI
N
F
T
NPA
G
MVTEA
V
YR
HT
G
FK
R
F
IG
V
C
N
I
PIG
MKMF
I
R
DV
L
M
L
K
D
SDD
L
S
I
D
LF
GLNHM
---VF
I
K
D
VLVN
G
K
--
S
R
F
A
ELL
DG
V
A
--------------
-
---S
GQ
L
KA
SS
V
KNI
FDLPFSEGLIR
SL
N
L
LP
C
SYL
L
YY
F
K
Q
K
E
-
MLAI
E
MG
E
Y
YK
G
GARAQ
V
V
Q
KV
EKQLFE
L
YK
N
P
----------
E
L
KVKP
KELE
QRGG
A
YYS
D
A
------
AC
EV
INAI
Y
N
--------
D
K
Q
A
EH
YVN
----------------
I
P
H
HG
H
IDN
I
P
ADWA
VEM
T
C
K
L
G
R
D
G
AT
P
H
P
----
R
I
TH
F
DDKVM
GL
I
H
T
IKG
F
E
I
A
AS
NA
A
L
SGEFND
V
LL
A
LN
LSP
---
L
V
H
S
DRD
A
E
L
L
A
R
E
M
I
L
AH
EK
WLP
NF
ADCIAELKKAH
fig|679205.4.peg.2489
Escherichia coli MS 124-1
MSQK
L
KVV
T
IGGGS
S
Y
TP
EL
L
E
G
F
I
KRYHE
LP
VSE
L
W
L
V
D
V
E
DG
K
EKLDI
I
FEL
CQ
R
M
I
D
N
AG
VPM
K
LYK
T
L
D
R
REAL
K
DADFV
TTQL
RVG
Q
L
-
P
A
RELDERIPL
S
HG
Y
LGQ
---
ET
N
G
A
GG
L
FK
GLRTIP
V
I
F
D
IVKD
V
EE
L
CPNAW
VI
N
F
T
NPA
G
MVTEA
V
YR
HT
G
FK
R
F
IG
V
C
N
I
PIG
MKMF
I
R
DV
L
M
L
K
D
SDD
L
S
I
D
LF
GLNHM
---VF
I
K
D
VLVN
G
K
--
S
R
F
A
ELL
DG
V
A
--------------
-
---S
GQ
L
KA
SS
V
KNI
FDLPFSEGLIR
SL
N
L
LP
C
SYL
L
YY
F
K
Q
K
E
-
MLAI
E
MG
E
Y
YK
G
GARAQ
V
V
Q
KV
EKQLFE
L
YK
N
P
----------
E
L
KVKP
KELE
QRGG
A
YYS
D
A
------
AC
EV
INAI
Y
N
--------
D
K
Q
A
EH
YVN
----------------
I
P
H
HG
H
IDN
I
P
ADWA
VEM
T
C
K
L
G
R
D
G
AT
P
H
P
----
R
I
TH
F
DDKVM
GL
I
H
T
IKG
F
E
I
A
AS
NA
A
L
SGEFND
V
LL
A
LN
LSP
---
L
V
H
S
DRD
A
E
L
L
A
R
E
M
I
L
AH
EK
WLP
NF
ADCIAELKKAH
fig|679204.3.peg.663
Escherichia coli MS 145-7
MSQK
L
KVV
T
IGGGS
S
Y
TP
EL
L
E
G
F
I
KRYHE
LP
VSE
L
W
L
V
D
V
E
DG
K
EKLDI
I
FEL
CQ
R
M
I
D
N
AG
VPM
K
LYK
T
L
D
R
REAL
K
DADFV
TTQL
RVG
Q
L
-
P
A
RELDERIPL
S
HG
Y
LGQ
---
ET
N
G
A
GG
L
FK
GLRTIP
V
I
F
D
IVKD
V
EE
L
CPNAW
VI
N
F
T
NPA
G
MVTEA
V
YR
HT
G
FK
R
F
IG
V
C
N
I
PIG
MKMF
I
R
DV
L
M
L
K
D
SDD
L
S
I
D
LF
GLNHM
---VF
I
K
D
VLVN
G
K
--
S
R
F
A
ELL
DG
V
A
--------------
-
---S
GQ
L
KA
SS
V
KNI
FDLPFSEGLIR
SL
N
L
LP
C
SYL
L
YY
F
K
Q
K
E
-
MLAI
E
MG
E
Y
YK
G
GARAQ
V
V
Q
KV
EKQLFE
L
YK
N
P
----------
E
L
KVKP
KELE
QRGG
A
YYS
D
A
------
AC
EV
INAI
Y
N
--------
D
K
Q
A
EH
YVN
----------------
I
P
H
HG
H
IDN
I
P
ADWA
VEM
T
C
K
L
G
R
D
G
AT
P
H
P
----
R
I
TH
F
DDKVM
GL
I
H
T
IKG
F
E
I
A
AS
NA
A
L
SGEFND
V
LL
A
LN
LSP
---
L
V
H
S
DRD
A
E
L
L
A
R
E
M
I
L
AH
EK
WLP
NF
ADCIAELKKAH
fig|749545.3.peg.2835
Escherichia coli MS 182-1
MSQK
L
KVV
T
IGGGS
S
Y
TP
EL
L
E
G
F
I
KRYHE
LP
VSE
L
W
L
V
D
V
E
DG
K
EKLDI
I
FEL
CQ
R
M
I
D
N
AG
VPM
K
LYK
T
L
D
R
REAL
K
DADFV
TTQL
RVG
Q
L
-
P
A
RELDERIPL
S
HG
Y
LGQ
---
ET
N
G
A
GG
L
FK
GLRTIP
V
I
F
D
IVKD
V
EE
L
CPNAW
VI
N
F
T
NPA
G
MVTEA
V
YR
HT
G
FK
R
F
IG
V
C
N
I
PIG
MKMF
I
R
DV
L
M
L
K
D
SDD
L
S
I
D
LF
GLNHM
---VF
I
K
D
VLVN
G
K
--
S
R
F
A
ELL
DG
V
A
--------------
-
---S
GQ
L
KA
SS
V
KNI
FDLPFSEGLIR
SL
N
L
LP
C
SYL
L
YY
F
K
Q
K
E
-
MLAI
E
MG
E
Y
YK
G
GARAQ
V
V
Q
KV
EKQLFE
L
YK
N
P
----------
E
L
KVKP
KELE
QRGG
A
YYS
D
A
------
AC
EV
INAI
Y
N
--------
D
K
Q
A
EH
YVN
----------------
I
P
H
HG
H
IDN
I
P
ADWA
VEM
T
C
K
L
G
R
D
G
AT
P
H
P
----
R
I
TH
F
DDKVM
GL
I
H
T
IKG
F
E
I
A
AS
NA
A
L
SGEFND
V
LL
A
LN
LSP
---
L
V
H
S
DRD
A
E
L
L
A
R
E
M
I
L
AH
EK
WLP
NF
ADCIAELKKAH
fig|749532.3.peg.2223
Escherichia coli MS 78-1
MSQK
L
KVV
T
IGGGS
S
Y
TP
EL
L
E
G
F
I
KRYHE
LP
VSE
L
W
L
V
D
V
E
DG
K
EKLDI
I
FEL
CQ
R
M
I
D
N
AG
VPM
K
LYK
T
L
D
R
REAL
K
DADFV
TTQL
RVG
Q
L
-
P
A
RELDERIPL
S
HG
Y
LGQ
---
ET
N
G
A
GG
L
FK
GLRTIP
V
I
F
D
IVKD
V
EE
L
CPNAW
VI
N
F
T
NPA
G
MVTEA
V
YR
HT
G
FK
R
F
IG
V
C
N
I
PIG
MKMF
I
R
DV
L
M
L
K
D
SDD
L
S
I
D
LF
GLNHM
---VF
I
K
D
VLVN
G
K
--
S
R
F
A
ELL
DG
V
A
--------------
-
---S
GQ
L
KA
SS
V
KNI
FDLPFSEGLIR
SL
N
L
LP
C
SYL
L
YY
F
K
Q
K
E
-
MLAI
E
MG
E
Y
YK
G
GARAQ
V
V
Q
KV
EKQLFE
L
YK
N
P
----------
E
L
KVKP
KELE
QRGG
A
YYS
D
A
------
AC
EV
INAI
Y
N
--------
D
K
Q
A
EH
YVN
----------------
I
P
H
HG
H
IDN
I
P
ADWA
VEM
T
C
K
L
G
R
D
G
AT
P
H
P
----
R
I
TH
F
DDKVM
GL
I
H
T
IKG
F
E
I
A
AS
NA
A
L
SGEFND
V
LL
A
LN
LSP
---
L
V
H
S
DRD
A
E
L
L
A
R
E
M
I
L
AH
EK
WLP
NF
ADCIAELKKAH
fig|749533.3.peg.2694
Escherichia coli MS 84-1
MSQK
L
KVV
T
IGGGS
S
Y
TP
EL
L
E
G
F
I
KRYHE
LP
VSE
L
W
L
V
D
V
E
DG
K
EKLDI
I
FEL
CQ
R
M
I
D
N
AG
VPM
K
LYK
T
L
D
R
REAL
K
DADFV
TTQL
RVG
Q
L
-
P
A
RELDERIPL
S
HG
Y
LGQ
---
ET
N
G
A
GG
L
FK
GLRTIP
V
I
F
D
IVKD
V
EE
L
CPNAW
VI
N
F
T
NPA
G
MVTEA
V
YR
HT
G
FK
R
F
IG
V
C
N
I
PIG
MKMF
I
R
DV
L
M
L
K
D
SDD
L
S
I
D
LF
GLNHM
---VF
I
K
D
VLVN
G
K
--
S
R
F
A
ELL
DG
V
A
--------------
-
---S
GQ
L
KA
SS
V
KNI
FDLPFSEGLIR
SL
N
L
LP
C
SYL
L
YY
F
K
Q
K
E
-
MLAI
E
MG
E
Y
YK
G
GARAQ
V
V
Q
KV
EKQLFE
L
YK
N
P
----------
E
L
KVKP
KELE
QRGG
A
YYS
D
A
------
AC
EV
INAI
Y
N
--------
D
K
Q
A
EH
YVN
----------------
I
P
H
HG
H
IDN
I
P
ADWA
VEM
T
C
K
L
G
R
D
G
AT
P
H
P
----
R
I
TH
F
DDKVM
GL
I
H
T
IKG
F
E
I
A
AS
NA
A
L
SGEFND
V
LL
A
LN
LSP
---
L
V
H
S
DRD
A
E
L
L
A
R
E
M
I
L
AH
EK
WLP
NF
ADCIAELKKAH
fig|585395.4.peg.2020
Escherichia coli O103:H2 str. 12009
MSQK
L
KVV
T
IGGGS
S
Y
TP
EL
L
E
G
F
I
KRYHE
LP
VSE
L
W
L
V
D
V
E
DG
K
EKLDI
I
FEL
CQ
R
M
I
D
N
AG
VPM
K
LYK
T
L
D
R
REAL
K
DADFV
TTQL
RVG
Q
L
-
P
A
RELDERIPL
S
HG
Y
LGQ
---
ET
N
G
A
GG
L
FK
GLRTIP
V
I
F
D
IVKD
V
EE
L
CPNAW
VI
N
F
T
NPA
G
MVTEA
V
YR
HT
G
FK
R
F
IG
V
C
N
I
PIG
MKMF
I
R
DV
L
M
L
K
D
SDD
L
S
I
D
LF
GLNHM
---VF
I
K
D
VLVN
G
K
--
S
R
F
A
ELL
DG
V
A
--------------
-
---S
GQ
L
KA
SS
V
KNI
FDLPFSEGLIR
SL
N
L
LP
C
SYL
L
YY
F
K
Q
K
E
-
MLAI
E
MG
E
Y
YK
G
GARAQ
V
V
Q
KV
EKQLFE
L
YK
N
P
----------
E
L
KVKP
KELE
QRGG
A
YYS
D
A
------
AC
EV
INAI
Y
N
--------
D
K
Q
A
EH
YVN
----------------
I
P
H
HG
H
IDN
I
P
ADWA
VEM
T
C
K
L
G
R
D
G
AT
P
H
P
----
R
I
TH
F
DDKVM
GL
I
H
T
IKG
F
E
I
A
AS
NA
A
L
SGEFND
V
LL
A
LN
LSP
---
L
V
H
S
DRD
A
E
L
L
A
R
E
M
I
L
AH
EK
WLP
NF
ADCIAELKKAH
fig|585396.4.peg.2329
Escherichia coli O111:H- str. 11128
MSQK
L
KVV
T
IGGGS
S
Y
TP
EL
L
E
G
F
I
KRYHE
LP
VSE
L
W
L
V
D
V
E
DG
K
EKLDI
I
FEL
CQ
R
M
I
D
N
AG
VPM
K
LYK
T
L
D
R
REAL
K
DADFV
TTQL
RVG
Q
L
-
P
A
RELDERIPL
S
HG
Y
LGQ
---
ET
N
G
A
GG
L
FK
GLRTIP
V
I
F
D
IVKD
V
EE
L
CPNAW
VI
N
F
T
NPA
G
MVTEA
V
YR
HT
G
FK
R
F
IG
V
C
N
I
PIG
MKMF
I
R
DV
L
M
L
K
D
SDD
L
S
I
D
LF
GLNHM
---VF
I
K
D
VLVN
G
K
--
S
R
F
A
ELL
DG
V
A
--------------
-
---S
GQ
L
KA
SS
V
KNI
FDLPFSEGLIR
SL
N
L
LP
C
SYL
L
YY
F
K
Q
K
E
-
MLAI
E
MG
E
Y
YK
G
GARAQ
V
V
Q
KV
EKQLFE
L
YK
N
P
----------
E
L
KVKP
KELE
QRGG
A
YYS
D
A
------
AC
EV
INAI
Y
N
--------
D
K
Q
A
EH
YVN
----------------
I
P
H
HG
H
IDN
I
P
ADWA
VEM
T
C
K
L
G
R
D
G
AT
P
H
P
----
R
I
TH
F
DDKVM
GL
I
H
T
IKG
F
E
I
A
AS
NA
A
L
SGEFND
V
LL
A
LN
LSP
---
L
V
H
S
DRD
A
E
L
L
A
R
E
M
I
L
AH
EK
WLP
NF
ADCIAELKKAH
fig|573235.3.peg.2547
Escherichia coli O26:H11 str. 11368
MSQK
L
KVV
T
IGGGS
S
Y
TP
EL
L
E
G
F
I
KRYHE
LP
VSE
L
W
L
V
D
V
E
DG
K
EKLDI
I
FEL
CQ
R
M
I
D
N
AG
VPM
K
LYK
T
L
D
R
REAL
K
DADFV
TTQL
RVG
Q
L
-
P
A
RELDERIPL
S
HG
Y
LGQ
---
ET
N
G
A
GG
L
FK
GLRTIP
V
I
F
D
IVKD
V
EE
L
CPNAW
VI
N
F
T
NPA
G
MVTEA
V
YR
HT
G
FK
R
F
IG
V
C
N
I
PIG
MKMF
I
R
DV
L
M
L
K
D
SDD
L
S
I
D
LF
GLNHM
---VF
I
K
D
VLVN
G
K
--
S
R
F
A
ELL
DG
V
A
--------------
-
---S
GQ
L
KA
SS
V
KNI
FDLPFSEGLIR
SL
N
L
LP
C
SYL
L
YY
F
K
Q
K
E
-
MLAI
E
MG
E
Y
YK
G
GARAQ
V
V
Q
KV
EKQLFE
L
YK
N
P
----------
E
L
KVKP
KELE
QRGG
A
YYS
D
A
------
AC
EV
INAI
Y
N
--------
D
K
Q
A
EH
YVN
----------------
I
P
H
HG
H
IDN
I
P
ADWA
VEM
T
C
K
L
G
R
D
G
AT
P
H
P
----
R
I
TH
F
DDKVM
GL
I
H
T
IKG
F
E
I
A
AS
NA
A
L
SGEFND
V
LL
A
LN
LSP
---
L
V
H
S
DRD
A
E
L
L
A
R
E
M
I
L
AH
EK
WLP
NF
ADCIAELKKAH
fig|409438.11.peg.2050
Escherichia coli SE11
MSQK
L
KVV
T
IGGGS
S
Y
TP
EL
L
E
G
F
I
KRYHE
LP
VSE
L
W
L
V
D
V
E
DG
K
EKLDI
I
FEL
CQ
R
M
I
D
N
AG
VPM
K
LYK
T
L
D
R
REAL
K
DADFV
TTQL
RVG
Q
L
-
P
A
RELDERIPL
S
HG
Y
LGQ
---
ET
N
G
A
GG
L
FK
GLRTIP
V
I
F
D
IVKD
V
EE
L
CPNAW
VI
N
F
T
NPA
G
MVTEA
V
YR
HT
G
FK
R
F
IG
V
C
N
I
PIG
MKMF
I
R
DV
L
M
L
K
D
SDD
L
S
I
D
LF
GLNHM
---VF
I
K
D
VLVN
G
K
--
S
R
F
A
ELL
DG
V
A
--------------
-
---S
GQ
L
KA
SS
V
KNI
FDLPFSEGLIR
SL
N
L
LP
C
SYL
L
YY
F
K
Q
K
E
-
MLAI
E
MG
E
Y
YK
G
GARAQ
V
V
Q
KV
EKQLFE
L
YK
N
P
----------
E
L
KVKP
KELE
QRGG
A
YYS
D
A
------
AC
EV
INAI
Y
N
--------
D
K
Q
A
EH
YVN
----------------
I
P
H
HG
H
IDN
I
P
ADWA
VEM
T
C
K
L
G
R
D
G
AT
P
H
P
----
R
I
TH
F
DDKVM
GL
I
H
T
IKG
F
E
I
A
AS
NA
A
L
SGEFND
V
LL
A
LN
LSP
---
L
V
H
S
DRD
A
E
L
L
A
R
E
M
I
L
AH
EK
WLP
NF
ADCIAELKKAH
fig|656443.3.peg.2408
Escherichia coli TA271
MSQK
L
KVV
T
IGGGS
S
Y
TP
EL
L
E
G
F
I
KRYHE
LP
VSE
L
W
L
V
D
V
E
DG
K
EKLDI
I
FEL
CQ
R
M
I
D
N
AG
VPM
K
LYK
T
L
D
R
REAL
K
DADFV
TTQL
RVG
Q
L
-
P
A
RELDERIPL
S
HG
Y
LGQ
---
ET
N
G
A
GG
L
FK
GLRTIP
V
I
F
D
IVKD
V
EE
L
CPNAW
VI
N
F
T
NPA
G
MVTEA
V
YR
HT
G
FK
R
F
IG
V
C
N
I
PIG
MKMF
I
R
DV
L
M
L
K
D
SDD
L
S
I
D
LF
GLNHM
---VF
I
K
D
VLVN
G
K
--
S
R
F
A
ELL
DG
V
A
--------------
-
---S
GQ
L
KA
SS
V
KNI
FDLPFSEGLIR
SL
N
L
LP
C
SYL
L
YY
F
K
Q
K
E
-
MLAI
E
MG
E
Y
YK
G
GARAQ
V
V
Q
KV
EKQLFE
L
YK
N
P
----------
E
L
KVKP
KELE
QRGG
A
YYS
D
A
------
AC
EV
INAI
Y
N
--------
D
K
Q
A
EH
YVN
----------------
I
P
H
HG
H
IDN
I
P
ADWA
VEM
T
C
K
L
G
R
D
G
AT
P
H
P
----
R
I
TH
F
DDKVM
GL
I
H
T
IKG
F
E
I
A
AS
NA
A
L
SGEFND
V
LL
A
LN
LSP
---
L
V
H
S
DRD
A
E
L
L
A
R
E
M
I
L
AH
EK
WLP
NF
ADCIAELKKAH
fig|595495.4.peg.2383
Escherichia coli KO11
MSQK
L
KVV
T
IGGGS
S
Y
TP
EL
L
E
G
F
I
KRYHE
LP
VSE
L
W
L
V
D
V
E
DG
K
EKLDI
I
FEL
CQ
R
M
I
D
N
AG
VPM
K
LYK
T
L
D
R
REAL
K
DADFV
TTQL
RVG
Q
L
-
P
A
RELDERIPL
S
HG
Y
LGQ
---
ET
N
G
A
GG
L
FK
GLRTIP
V
I
F
D
IVKD
V
EE
L
CPNAW
VI
N
F
T
NPA
G
MVTEA
V
YR
HT
G
FK
R
F
IG
V
C
N
I
PIG
MKMF
I
R
DV
L
M
L
K
D
SDD
L
S
I
E
LF
GLNHM
---VF
I
K
D
VLVN
G
K
--
S
R
F
A
ELL
DG
V
A
--------------
-
---S
GQ
L
KA
SS
V
KNI
FDLPFSEGLIR
SL
N
L
LP
C
SYL
L
YY
F
K
Q
K
E
-
MLAI
E
MG
E
Y
YK
G
GARAQ
V
V
Q
KV
EKQLFE
L
YK
N
P
----------
E
L
KVKP
KELE
QRGG
A
YYS
D
A
------
AC
EV
INAI
Y
N
--------
D
K
Q
A
EH
YVN
----------------
I
P
H
HG
H
IDN
I
P
ADWA
VEM
T
C
K
L
G
R
D
G
AT
P
H
P
----
R
I
TH
F
DDKVM
GL
I
H
T
IKG
F
E
I
A
AS
NA
A
L
SGEFND
V
LL
A
LN
LSP
---
L
V
H
S
DRD
A
E
L
L
A
R
E
M
I
L
AH
EK
WLP
NF
ADCIAELKKAH
fig|566546.3.peg.906
Escherichia coli W
MSQK
L
KVV
T
IGGGS
S
Y
TP
EL
L
E
G
F
I
KRYHE
LP
VSE
L
W
L
V
D
V
E
DG
K
EKLDI
I
FEL
CQ
R
M
I
D
N
AG
VPM
K
LYK
T
L
D
R
REAL
K
DADFV
TTQL
RVG
Q
L
-
P
A
RELDERIPL
S
HG
Y
LGQ
---
ET
N
G
A
GG
L
FK
GLRTIP
V
I
F
D
IVKD
V
EE
L
CPNAW
VI
N
F
T
NPA
G
MVTEA
V
YR
HT
G
FK
R
F
IG
V
C
N
I
PIG
MKMF
I
R
DV
L
M
L
K
D
SDD
L
S
I
E
LF
GLNHM
---VF
I
K
D
VLVN
G
K
--
S
R
F
A
ELL
DG
V
A
--------------
-
---S
GQ
L
KA
SS
V
KNI
FDLPFSEGLIR
SL
N
L
LP
C
SYL
L
YY
F
K
Q
K
E
-
MLAI
E
MG
E
Y
YK
G
GARAQ
V
V
Q
KV
EKQLFE
L
YK
N
P
----------
E
L
KVKP
KELE
QRGG
A
YYS
D
A
------
AC
EV
INAI
Y
N
--------
D
K
Q
A
EH
YVN
----------------
I
P
H
HG
H
IDN
I
P
ADWA
VEM
T
C
K
L
G
R
D
G
AT
P
H
P
----
R
I
TH
F
DDKVM
GL
I
H
T
IKG
F
E
I
A
AS
NA
A
L
SGEFND
V
LL
A
LN
LSP
---
L
V
H
S
DRD
A
E
L
L
A
R
E
M
I
L
AH
EK
WLP
NF
ADCIAELKKAH
fig|566546.4.peg.1891
Escherichia coli W
MSQK
L
KVV
T
IGGGS
S
Y
TP
EL
L
E
G
F
I
KRYHE
LP
VSE
L
W
L
V
D
V
E
DG
K
EKLDI
I
FEL
CQ
R
M
I
D
N
AG
VPM
K
LYK
T
L
D
R
REAL
K
DADFV
TTQL
RVG
Q
L
-
P
A
RELDERIPL
S
HG
Y
LGQ
---
ET
N
G
A
GG
L
FK
GLRTIP
V
I
F
D
IVKD
V
EE
L
CPNAW
VI
N
F
T
NPA
G
MVTEA
V
YR
HT
G
FK
R
F
IG
V
C
N
I
PIG
MKMF
I
R
DV
L
M
L
K
D
SDD
L
S
I
E
LF
GLNHM
---VF
I
K
D
VLVN
G
K
--
S
R
F
A
ELL
DG
V
A
--------------
-
---S
GQ
L
KA
SS
V
KNI
FDLPFSEGLIR
SL
N
L
LP
C
SYL
L
YY
F
K
Q
K
E
-
MLAI
E
MG
E
Y
YK
G
GARAQ
V
V
Q
KV
EKQLFE
L
YK
N
P
----------
E
L
KVKP
KELE
QRGG
A
YYS
D
A
------
AC
EV
INAI
Y
N
--------
D
K
Q
A
EH
YVN
----------------
I
P
H
HG
H
IDN
I
P
ADWA
VEM
T
C
K
L
G
R
D
G
AT
P
H
P
----
R
I
TH
F
DDKVM
GL
I
H
T
IKG
F
E
I
A
AS
NA
A
L
SGEFND
V
LL
A
LN
LSP
---
L
V
H
S
DRD
A
E
L
L
A
R
E
M
I
L
AH
EK
WLP
NF
ADCIAELKKAH
fig|358709.5.peg.3235
Escherichia coli 101-1
MSQK
L
KVV
T
IGGGS
S
Y
TP
EL
L
E
G
F
I
KRYHE
LP
VSE
L
W
L
V
D
V
E
GG
K
AKLDI
I
FDL
CQ
R
M
I
D
N
AG
VPM
K
LYK
T
L
D
R
REAL
K
DADFV
TTQL
RVG
Q
L
-
P
A
RELDERIPL
S
HG
Y
LGQ
---
ET
N
G
A
GG
L
FK
GLRTIP
V
I
F
D
IVKD
V
EE
L
CPNAW
VI
N
F
T
NPA
G
MVTEA
V
YR
HT
G
FK
R
F
IG
V
C
N
I
PIG
MKMF
I
R
DV
L
M
L
K
D
SDD
L
S
I
D
LF
GLNHM
---VF
I
K
D
VLVN
G
K
--
S
R
F
A
ELL
DG
V
A
--------------
-
---S
GQ
L
KA
SS
V
KNI
FDLPFSEGLIR
SL
N
L
LP
C
SYL
L
YY
F
K
Q
K
E
-
MLAI
E
MG
E
Y
YK
G
GARAQ
V
V
Q
KV
EKQLFE
L
YK
N
P
----------
E
L
KVKP
KELE
QRGG
A
YYS
D
A
------
AC
EV
INAI
Y
N
--------
D
K
Q
A
EH
YVN
----------------
I
P
H
HG
H
IDN
I
P
ADWA
VEM
T
C
K
L
G
R
D
G
AT
P
H
P
----
R
I
TH
F
DDKVM
GL
I
H
T
IKG
F
E
I
A
AS
NA
A
L
SGEFND
V
LL
A
LN
LSP
---
L
V
H
S
DRD
A
E
L
L
A
R
E
M
I
L
AH
EK
WLP
NF
ADCIAELKKAH
fig|344610.3.peg.2409
Escherichia coli 53638
MSQK
L
KVV
T
IGGGS
S
Y
TP
EL
L
E
G
F
I
KRYHE
LP
VSE
L
W
L
V
D
V
E
GG
K
AKLDI
I
FDL
CQ
R
M
I
D
N
AG
VPM
K
LYK
T
L
D
R
REAL
K
DADFV
TTQL
RVG
Q
L
-
P
A
RELDERIPL
S
HG
Y
LGQ
---
ET
N
G
A
GG
L
FK
GLRTIP
V
I
F
D
IVKD
V
EE
L
CPNAW
VI
N
F
T
NPA
G
MVTEA
V
YR
HT
G
FK
R
F
IG
V
C
N
I
PIG
MKMF
I
R
DV
L
M
L
K
D
SDD
L
S
I
D
LF
GLNHM
---VF
I
K
D
VLVN
G
K
--
S
R
F
A
ELL
DG
V
A
--------------
-
---S
GQ
L
KA
SS
V
KNI
FDLPFSEGLIR
SL
N
L
LP
C
SYL
L
YY
F
K
Q
K
E
-
MLAI
E
MG
E
Y
YK
G
GARAQ
V
V
Q
KV
EKQLFE
L
YK
N
P
----------
E
L
KVKP
KELE
QRGG
A
YYS
D
A
------
AC
EV
INAI
Y
N
--------
D
K
Q
A
EH
YVN
----------------
I
P
H
HG
H
IDN
I
P
ADWA
VEM
T
C
K
L
G
R
D
G
AT
P
H
P
----
R
I
TH
F
DDKVM
GL
I
H
T
IKG
F
E
I
A
AS
NA
A
L
SGEFND
V
LL
A
LN
LSP
---
L
V
H
S
DRD
A
E
L
L
A
R
E
M
I
L
AH
EK
WLP
NF
ADCIAELKKAH
fig|344610.7.peg.5389
Escherichia coli 53638
MSQK
L
KVV
T
IGGGS
S
Y
TP
EL
L
E
G
F
I
KRYHE
LP
VSE
L
W
L
V
D
V
E
GG
K
AKLDI
I
FDL
CQ
R
M
I
D
N
AG
VPM
K
LYK
T
L
D
R
REAL
K
DADFV
TTQL
RVG
Q
L
-
P
A
RELDERIPL
S
HG
Y
LGQ
---
ET
N
G
A
GG
L
FK
GLRTIP
V
I
F
D
IVKD
V
EE
L
CPNAW
VI
N
F
T
NPA
G
MVTEA
V
YR
HT
G
FK
R
F
IG
V
C
N
I
PIG
MKMF
I
R
DV
L
M
L
K
D
SDD
L
S
I
D
LF
GLNHM
---VF
I
K
D
VLVN
G
K
--
S
R
F
A
ELL
DG
V
A
--------------
-
---S
GQ
L
KA
SS
V
KNI
FDLPFSEGLIR
SL
N
L
LP
C
SYL
L
YY
F
K
Q
K
E
-
MLAI
E
MG
E
Y
YK
G
GARAQ
V
V
Q
KV
EKQLFE
L
YK
N
P
----------
E
L
KVKP
KELE
QRGG
A
YYS
D
A
------
AC
EV
INAI
Y
N
--------
D
K
Q
A
EH
YVN
----------------
I
P
H
HG
H
IDN
I
P
ADWA
VEM
T
C
K
L
G
R
D
G
AT
P
H
P
----
R
I
TH
F
DDKVM
GL
I
H
T
IKG
F
E
I
A
AS
NA
A
L
SGEFND
V
LL
A
LN
LSP
---
L
V
H
S
DRD
A
E
L
L
A
R
E
M
I
L
AH
EK
WLP
NF
ADCIAELKKAH
fig|413997.3.peg.1782
Escherichia coli B str. REL606
MSQK
L
KVV
T
IGGGS
S
Y
TP
EL
L
E
G
F
I
KRYHE
LP
VSE
L
W
L
V
D
V
E
GG
K
AKLDI
I
FDL
CQ
R
M
I
D
N
AG
VPM
K
LYK
T
L
D
R
REAL
K
DADFV
TTQL
RVG
Q
L
-
P
A
RELDERIPL
S
HG
Y
LGQ
---
ET
N
G
A
GG
L
FK
GLRTIP
V
I
F
D
IVKD
V
EE
L
CPNAW
VI
N
F
T
NPA
G
MVTEA
V
YR
HT
G
FK
R
F
IG
V
C
N
I
PIG
MKMF
I
R
DV
L
M
L
K
D
SDD
L
S
I
D
LF
GLNHM
---VF
I
K
D
VLVN
G
K
--
S
R
F
A
ELL
DG
V
A
--------------
-
---S
GQ
L
KA
SS
V
KNI
FDLPFSEGLIR
SL
N
L
LP
C
SYL
L
YY
F
K
Q
K
E
-
MLAI
E
MG
E
Y
YK
G
GARAQ
V
V
Q
KV
EKQLFE
L
YK
N
P
----------
E
L
KVKP
KELE
QRGG
A
YYS
D
A
------
AC
EV
INAI
Y
N
--------
D
K
Q
A
EH
YVN
----------------
I
P
H
HG
H
IDN
I
P
ADWA
VEM
T
C
K
L
G
R
D
G
AT
P
H
P
----
R
I
TH
F
DDKVM
GL
I
H
T
IKG
F
E
I
A
AS
NA
A
L
SGEFND
V
LL
A
LN
LSP
---
L
V
H
S
DRD
A
E
L
L
A
R
E
M
I
L
AH
EK
WLP
NF
ADCIAELKKAH
fig|511693.5.peg.1810
Escherichia coli BL21
MSQK
L
KVV
T
IGGGS
S
Y
TP
EL
L
E
G
F
I
KRYHE
LP
VSE
L
W
L
V
D
V
E
GG
K
AKLDI
I
FDL
CQ
R
M
I
D
N
AG
VPM
K
LYK
T
L
D
R
REAL
K
DADFV
TTQL
RVG
Q
L
-
P
A
RELDERIPL
S
HG
Y
LGQ
---
ET
N
G
A
GG
L
FK
GLRTIP
V
I
F
D
IVKD
V
EE
L
CPNAW
VI
N
F
T
NPA
G
MVTEA
V
YR
HT
G
FK
R
F
IG
V
C
N
I
PIG
MKMF
I
R
DV
L
M
L
K
D
SDD
L
S
I
D
LF
GLNHM
---VF
I
K
D
VLVN
G
K
--
S
R
F
A
ELL
DG
V
A
--------------
-
---S
GQ
L
KA
SS
V
KNI
FDLPFSEGLIR
SL
N
L
LP
C
SYL
L
YY
F
K
Q
K
E
-
MLAI
E
MG
E
Y
YK
G
GARAQ
V
V
Q
KV
EKQLFE
L
YK
N
P
----------
E
L
KVKP
KELE
QRGG
A
YYS
D
A
------
AC
EV
INAI
Y
N
--------
D
K
Q
A
EH
YVN
----------------
I
P
H
HG
H
IDN
I
P
ADWA
VEM
T
C
K
L
G
R
D
G
AT
P
H
P
----
R
I
TH
F
DDKVM
GL
I
H
T
IKG
F
E
I
A
AS
NA
A
L
SGEFND
V
LL
A
LN
LSP
---
L
V
H
S
DRD
A
E
L
L
A
R
E
M
I
L
AH
EK
WLP
NF
ADCIAELKKAH
fig|469008.4.peg.1968
Escherichia coli BL21(DE3)
MSQK
L
KVV
T
IGGGS
S
Y
TP
EL
L
E
G
F
I
KRYHE
LP
VSE
L
W
L
V
D
V
E
GG
K
AKLDI
I
FDL
CQ
R
M
I
D
N
AG
VPM
K
LYK
T
L
D
R
REAL
K
DADFV
TTQL
RVG
Q
L
-
P
A
RELDERIPL
S
HG
Y
LGQ
---
ET
N
G
A
GG
L
FK
GLRTIP
V
I
F
D
IVKD
V
EE
L
CPNAW
VI
N
F
T
NPA
G
MVTEA
V
YR
HT
G
FK
R
F
IG
V
C
N
I
PIG
MKMF
I
R
DV
L
M
L
K
D
SDD
L
S
I
D
LF
GLNHM
---VF
I
K
D
VLVN
G
K
--
S
R
F
A
ELL
DG
V
A
--------------
-
---S
GQ
L
KA
SS
V
KNI
FDLPFSEGLIR
SL
N
L
LP
C
SYL
L
YY
F
K
Q
K
E
-
MLAI
E
MG
E
Y
YK
G
GARAQ
V
V
Q
KV
EKQLFE
L
YK
N
P
----------
E
L
KVKP
KELE
QRGG
A
YYS
D
A
------
AC
EV
INAI
Y
N
--------
D
K
Q
A
EH
YVN
----------------
I
P
H
HG
H
IDN
I
P
ADWA
VEM
T
C
K
L
G
R
D
G
AT
P
H
P
----
R
I
TH
F
DDKVM
GL
I
H
T
IKG
F
E
I
A
AS
NA
A
L
SGEFND
V
LL
A
LN
LSP
---
L
V
H
S
DRD
A
E
L
L
A
R
E
M
I
L
AH
EK
WLP
NF
ADCIAELKKAH
fig|749547.3.peg.2948
Escherichia coli MS 187-1
MSQK
L
KVV
T
IGGGS
S
Y
TP
EL
L
E
G
F
I
KRYHE
LP
VSE
L
W
L
V
D
V
E
GG
K
TKLDI
I
FDL
CQ
R
M
I
D
N
AG
VPM
K
LYK
T
L
D
R
REAL
K
DADFV
TTQL
RVG
Q
L
-
P
A
RELDERIPL
S
HG
Y
LGQ
---
ET
N
G
A
GG
L
FK
GLRTIP
V
I
F
D
IVKD
V
EE
L
CPNAW
VI
N
F
T
NPA
G
MVTEA
V
YR
HT
G
FK
R
F
IG
V
C
N
I
PIG
MKMF
I
R
DV
L
M
L
K
D
SDD
L
S
I
D
LF
GLNHM
---VF
I
K
D
VLVN
G
K
--
S
R
F
A
ELL
DG
V
A
--------------
-
---S
GQ
L
KA
SS
V
KNI
FDLPFSEGLIR
SL
N
L
LP
C
SYL
L
YY
F
K
Q
K
E
-
MLAI
E
MG
E
Y
YK
G
GARAQ
V
V
Q
KV
EKQLFE
L
YK
N
P
----------
E
L
KVKP
KELE
QRGG
A
YYS
D
A
------
AC
EV
INAI
Y
N
--------
D
K
Q
A
EH
YVN
----------------
I
P
H
HG
H
IDN
I
P
ADWA
VEM
T
C
K
L
G
R
D
G
AT
P
H
P
----
R
I
TH
F
DDKVM
GL
I
H
T
IKG
F
E
I
A
AS
NA
A
L
SGEFND
V
LL
A
LN
LSP
---
L
V
H
S
DRD
A
E
L
L
A
R
E
M
I
L
AH
EK
WLP
NF
ADCIAELKKAH
fig|637912.3.peg.1461
Escherichia coli OP50
MSQK
L
KVV
T
IGGGS
S
Y
TP
EL
L
E
G
F
I
KRYHE
LP
VSE
L
W
L
V
D
V
E
GG
K
AKLDI
I
FDL
CQ
R
M
I
D
N
AG
VPM
K
LYK
T
L
D
R
REAL
K
DADFV
TTQL
RVG
Q
L
-
P
A
RELDERIPL
S
HG
Y
LGQ
---
ET
N
G
A
GG
L
FK
GLRTIP
V
I
F
D
IVKD
V
EE
L
CPNAW
VI
N
F
T
NPA
G
MVTEA
V
YR
HT
G
FK
R
F
IG
V
C
N
I
PIG
MKMF
I
R
DV
L
M
L
K
D
SDD
L
S
I
D
LF
GLNHM
---VF
I
K
D
VLVN
G
K
--
S
R
F
A
ELL
DG
V
A
--------------
-
---S
GQ
L
KA
SS
V
KNI
FDLPFSEGLIR
SL
N
L
LP
C
SYL
L
YY
F
K
Q
K
E
-
MLAI
E
MG
E
Y
YK
G
GARAQ
V
V
Q
KV
EKQLFE
L
YK
N
P
----------
E
L
KVKP
KELE
QRGG
A
YYS
D
A
------
AC
EV
INAI
Y
N
--------
D
K
Q
A
EH
YVN
----------------
I
P
H
HG
H
IDN
I
P
ADWA
VEM
T
C
K
L
G
R
D
G
AT
P
H
P
----
R
I
TH
F
DDKVM
GL
I
H
T
IKG
F
E
I
A
AS
NA
A
L
SGEFND
V
LL
A
LN
LSP
---
L
V
H
S
DRD
A
E
L
L
A
R
E
M
I
L
AH
EK
WLP
NF
ADCIAELKKAH
fig|749527.3.peg.3469
Escherichia coli MS 21-1
M
R
QK
L
KVV
T
IGGGS
S
Y
TP
EL
L
E
G
F
I
KRYHE
LP
VSE
L
W
L
V
D
V
E
DG
K
EKLDI
I
FDL
CQ
R
M
I
D
N
AG
VPM
K
LYK
T
L
D
R
REAL
K
DADFV
TTQL
RVG
Q
L
-
P
A
RELDERIPL
S
HG
Y
LGQ
---
ET
N
G
A
GG
L
FK
GLRTIP
V
I
F
D
IVKD
V
EE
L
CPNAW
VI
N
F
T
NPA
G
MVTEA
V
YR
HT
G
FK
R
F
IG
V
C
N
I
PIG
MKMF
I
R
DV
L
M
L
K
D
SDD
L
S
I
D
LF
GLNHM
---VF
I
K
D
VLVN
G
K
--
S
R
F
A
ELL
DG
V
A
--------------
-
---S
GQ
L
KA
SG
V
KNI
FDLPFSEGLIR
SL
N
L
LP
C
SYL
L
YY
F
K
Q
K
E
-
MLAI
E
MG
E
Y
YK
G
GARAQ
V
V
Q
KV
EKQLFE
L
YK
N
P
----------
E
L
KVKP
KELE
QRGG
A
YYS
D
A
------
AC
EV
INAI
Y
N
--------
D
K
Q
A
EH
YVN
----------------
I
P
H
HG
H
IDN
I
P
ADWA
VEM
T
C
T
L
G
R
D
G
AT
P
H
P
----
R
I
TH
F
DDKVM
GL
I
H
T
IKG
F
E
I
A
AS
NA
A
L
SGEFND
V
LL
A
LN
LSP
---
L
V
H
S
DRD
A
E
L
L
A
R
E
M
I
L
AH
EK
WLP
NF
ADCIAELKKAH
fig|585057.4.peg.1382
Escherichia coli IAI39
MSQK
L
KVV
T
IGGGS
S
Y
TP
EL
L
E
G
F
I
KRYHE
LP
VSE
L
W
L
V
D
V
E
DG
K
EKLDI
I
FDL
CQ
R
M
I
D
N
AG
VPM
K
LYK
T
L
D
R
REAL
K
DADFV
TTQL
RVG
Q
L
-
P
A
RELDERIPL
S
HG
Y
LGQ
---
ET
N
G
A
GG
L
FK
GLRTIP
V
I
F
D
IVKD
V
EE
L
CPNAW
VI
N
F
T
NPA
G
MVTEA
V
YR
HT
G
FK
R
F
IG
V
C
N
I
PIG
MKMF
I
R
DV
L
M
L
K
D
SDD
L
S
I
D
LF
GLNHM
---VF
I
K
D
VLVN
G
K
--
S
R
F
A
ELL
DG
V
A
--------------
-
---S
GQ
L
KA
SG
V
KNI
FDLPFSEGLIR
SL
N
L
LP
C
SYL
L
YY
F
K
Q
K
E
-
MLAI
E
MG
E
Y
YK
G
GARAQ
V
V
Q
KV
EKQLFE
L
YK
N
P
----------
E
L
KVKP
KELE
QRGG
A
YYS
D
A
------
AC
EV
INAI
Y
N
--------
D
K
Q
A
EH
YVN
----------------
I
P
H
HG
H
IDN
I
P
ADWA
VEM
T
C
T
L
G
R
D
G
AT
P
H
P
----
R
I
TH
F
DDKVM
GL
I
H
T
IKS
F
E
I
A
AS
NA
A
L
SGEFND
V
LL
A
LN
LSP
---
L
V
H
S
DRD
A
E
L
L
A
R
E
M
I
L
AH
EK
WLP
NF
ADCIAELKKAH
fig|585057.6.peg.1382
Escherichia coli IAI39
MSQK
L
KVV
T
IGGGS
S
Y
TP
EL
L
E
G
F
I
KRYHE
LP
VSE
L
W
L
V
D
V
E
DG
K
EKLDI
I
FDL
CQ
R
M
I
D
N
AG
VPM
K
LYK
T
L
D
R
REAL
K
DADFV
TTQL
RVG
Q
L
-
P
A
RELDERIPL
S
HG
Y
LGQ
---
ET
N
G
A
GG
L
FK
GLRTIP
V
I
F
D
IVKD
V
EE
L
CPNAW
VI
N
F
T
NPA
G
MVTEA
V
YR
HT
G
FK
R
F
IG
V
C
N
I
PIG
MKMF
I
R
DV
L
M
L
K
D
SDD
L
S
I
D
LF
GLNHM
---VF
I
K
D
VLVN
G
K
--
S
R
F
A
ELL
DG
V
A
--------------
-
---S
GQ
L
KA
SG
V
KNI
FDLPFSEGLIR
SL
N
L
LP
C
SYL
L
YY
F
K
Q
K
E
-
MLAI
E
MG
E
Y
YK
G
GARAQ
V
V
Q
KV
EKQLFE
L
YK
N
P
----------
E
L
KVKP
KELE
QRGG
A
YYS
D
A
------
AC
EV
INAI
Y
N
--------
D
K
Q
A
EH
YVN
----------------
I
P
H
HG
H
IDN
I
P
ADWA
VEM
T
C
T
L
G
R
D
G
AT
P
H
P
----
R
I
TH
F
DDKVM
GL
I
H
T
IKS
F
E
I
A
AS
NA
A
L
SGEFND
V
LL
A
LN
LSP
---
L
V
H
S
DRD
A
E
L
L
A
R
E
M
I
L
AH
EK
WLP
NF
ADCIAELKKAH
fig|439855.10.peg.1616
Escherichia coli SMS-3-5
MSQK
L
KVV
T
IGGGS
S
Y
TP
EL
L
E
G
F
I
KRYHE
LP
VSE
L
W
L
V
D
V
E
DG
K
EKLDI
I
FDL
CQ
R
M
I
D
N
AG
VPM
K
LYK
T
L
D
R
REAL
K
DADFV
TTQL
RVG
Q
L
-
P
A
RELDERIPL
S
HG
Y
LGQ
---
ET
N
G
A
GG
L
FK
GLRTIP
V
I
F
D
IVKD
V
EE
L
CPNAW
VI
N
F
T
NPA
G
MVTEA
V
YR
HT
G
FK
R
F
IG
V
C
N
I
PIG
MKMF
I
R
DV
L
M
L
K
D
SDD
L
S
I
D
LF
GLNHM
---VF
I
K
D
VLVN
G
K
--
S
R
F
A
ELL
DG
V
A
--------------
-
---S
GQ
L
KA
SG
V
KNI
FDLPFSEGLIR
SL
N
L
LP
C
SYL
L
YY
F
K
Q
K
E
-
MLAI
E
MG
E
Y
YK
G
GARAQ
V
V
Q
KV
EKQLFE
L
YK
N
P
----------
E
L
KVKP
KELE
QRGG
A
YYS
D
A
------
AC
EV
INAI
Y
N
--------
D
K
Q
A
EH
YVN
----------------
I
P
H
HG
H
IDN
I
P
ADWA
VEM
T
C
T
L
G
R
D
G
AT
P
H
P
----
R
I
TH
F
DDKVM
GL
I
H
T
IKS
F
E
I
A
AS
NA
A
L
SGEFND
V
LL
A
LN
LSP
---
L
V
H
S
DRD
A
E
L
L
A
R
E
M
I
L
AH
EK
WLP
NF
ADCIAELKKAH
fig|749537.3.peg.1457
Escherichia coli MS 115-1
MSQK
L
KVV
T
IGGGS
S
Y
TP
EL
L
E
G
F
I
KRYHE
LP
VSE
L
W
L
V
D
V
E
GG
K
AKLDI
I
FDL
CQ
R
M
I
D
N
AG
VPM
K
LYK
T
L
D
R
REAL
K
DADFV
TTQL
RVG
Q
L
-
P
A
RELDERIPL
S
HG
Y
LGQ
---
ET
N
G
A
GG
L
FK
GLRTIP
V
I
F
D
IVKD
V
EE
L
CPNAW
VI
N
F
T
NPA
G
MVTEA
V
YR
HT
G
FK
R
F
IG
V
C
N
I
PIG
MKMF
I
R
DV
L
M
L
K
D
SDD
L
S
I
D
LF
GLNHM
---VF
I
K
D
VLVN
G
K
--
S
R
F
A
ELL
DG
V
A
--------------
-
---S
GQ
L
KA
SS
V
KNI
FDLPFSEGLIR
SL
N
L
LP
C
SYL
L
YY
F
K
Q
K
E
-
MLAI
E
MG
E
Y
YK
G
GARAQ
V
V
Q
KV
EKQLFE
L
YK
N
P
----------
E
L
KVKP
KELE
QRGG
A
YYS
D
A
------
AC
EV
INAI
Y
N
--------
D
K
Q
A
EH
YVN
----------------
I
P
H
HG
H
M
DN
I
P
ADWA
VEM
T
C
K
L
G
R
D
G
AT
P
H
P
----
R
I
TH
F
DDKVM
GL
I
H
T
IKG
F
E
I
A
AS
NA
A
L
SGEFND
V
LL
A
LN
LSP
---
L
V
H
S
DRD
A
E
L
L
A
R
E
M
I
L
AH
EK
WLP
NF
ADCIAELKKAH
fig|481805.3.peg.2046
Escherichia coli ATCC 8739
MSQK
L
KVV
T
IGGGS
S
Y
TP
EL
L
E
G
F
I
KRYHE
LP
VSE
L
W
L
V
D
V
E
GG
K
AKLDI
I
FDL
CQ
R
M
I
D
N
AG
VPM
K
LYK
T
L
D
R
REAL
K
DADFV
TTQL
RVG
Q
L
-
P
A
RELDERIPL
S
HG
Y
LGQ
---
ET
N
G
A
GG
L
FK
GLRTIP
V
I
F
D
IVKD
V
EE
L
CPNAW
VI
N
F
T
NPA
G
MVTEA
V
YR
HT
G
FK
R
F
IG
V
C
N
I
PIG
MKMF
I
R
DV
L
M
L
K
D
SDD
L
S
I
D
LF
GLNHM
---VF
I
K
D
VLVN
G
K
--
S
R
F
A
ELL
DG
V
A
--------------
-
---S
GQ
L
KA
SG
V
KNI
FDLPFSEGLIR
SL
N
L
LP
C
SYL
L
YY
F
K
Q
K
E
-
MLAI
E
MG
E
Y
YK
G
GARAQ
V
V
Q
KV
EKQLFE
L
YK
N
P
----------
E
L
KVKP
KELE
QRGG
A
YYS
D
A
------
AC
EV
INAI
Y
N
--------
D
K
Q
A
EH
YVN
----------------
I
P
H
HG
H
IDN
I
P
ADWA
VEM
T
C
K
L
G
R
D
G
AT
P
H
P
----
R
I
TH
F
DDKVM
GL
I
H
T
IKG
F
E
I
A
AS
NA
A
L
SGEFND
V
LL
A
LN
LSP
---
L
V
H
S
DRD
A
E
L
L
A
R
E
M
I
L
AH
EK
WLP
NF
ADCIAELKKAH
fig|481805.6.peg.2041
Escherichia coli ATCC 8739
MSQK
L
KVV
T
IGGGS
S
Y
TP
EL
L
E
G
F
I
KRYHE
LP
VSE
L
W
L
V
D
V
E
GG
K
AKLDI
I
FDL
CQ
R
M
I
D
N
AG
VPM
K
LYK
T
L
D
R
REAL
K
DADFV
TTQL
RVG
Q
L
-
P
A
RELDERIPL
S
HG
Y
LGQ
---
ET
N
G
A
GG
L
FK
GLRTIP
V
I
F
D
IVKD
V
EE
L
CPNAW
VI
N
F
T
NPA
G
MVTEA
V
YR
HT
G
FK
R
F
IG
V
C
N
I
PIG
MKMF
I
R
DV
L
M
L
K
D
SDD
L
S
I
D
LF
GLNHM
---VF
I
K
D
VLVN
G
K
--
S
R
F
A
ELL
DG
V
A
--------------
-
---S
GQ
L
KA
SG
V
KNI
FDLPFSEGLIR
SL
N
L
LP
C
SYL
L
YY
F
K
Q
K
E
-
MLAI
E
MG
E
Y
YK
G
GARAQ
V
V
Q
KV
EKQLFE
L
YK
N
P
----------
E
L
KVKP
KELE
QRGG
A
YYS
D
A
------
AC
EV
INAI
Y
N
--------
D
K
Q
A
EH
YVN
----------------
I
P
H
HG
H
IDN
I
P
ADWA
VEM
T
C
K
L
G
R
D
G
AT
P
H
P
----
R
I
TH
F
DDKVM
GL
I
H
T
IKG
F
E
I
A
AS
NA
A
L
SGEFND
V
LL
A
LN
LSP
---
L
V
H
S
DRD
A
E
L
L
A
R
E
M
I
L
AH
EK
WLP
NF
ADCIAELKKAH
fig|550676.3.peg.2045
Escherichia coli B185
MSQK
L
KVV
T
IGGGS
S
Y
TP
EL
L
E
G
F
I
KRYHE
LP
VSE
L
W
L
V
D
V
E
GG
K
AKLDI
I
FDL
CQ
R
M
I
D
N
AG
VPM
K
LYK
T
L
D
R
REAL
K
DADFV
TTQL
RVG
Q
L
-
P
A
RELDERIPL
S
HG
Y
LGQ
---
ET
N
G
A
GG
L
FK
GLRTIP
V
I
F
D
IVKD
V
EE
L
CPNAW
VI
N
F
T
NPA
G
MVTEA
V
YR
HT
G
FK
R
F
IG
V
C
N
I
PIG
MKMF
I
R
DV
L
M
L
K
D
SDD
L
S
I
D
LF
GLNHM
---VF
I
K
D
VLVN
G
K
--
S
R
F
A
ELL
DG
V
A
--------------
-
---S
GQ
L
KA
SG
V
KNI
FDLPFSEGLIR
SL
N
L
LP
C
SYL
L
YY
F
K
Q
K
E
-
MLAI
E
MG
E
Y
YK
G
GARAQ
V
V
Q
KV
EKQLFE
L
YK
N
P
----------
E
L
KVKP
KELE
QRGG
A
YYS
D
A
------
AC
EV
INAI
Y
N
--------
D
K
Q
A
EH
YVN
----------------
I
P
H
HG
H
IDN
I
P
ADWA
VEM
T
C
K
L
G
R
D
G
AT
P
H
P
----
R
I
TH
F
DDKVM
GL
I
H
T
IKG
F
E
I
A
AS
NA
A
L
SGEFND
V
LL
A
LN
LSP
---
L
V
H
S
DRD
A
E
L
L
A
R
E
M
I
L
AH
EK
WLP
NF
ADCIAELKKAH
fig|331112.3.peg.1710
Escherichia coli HS
MSQK
L
KVV
T
IGGGS
S
Y
TP
EL
L
E
G
F
I
KRYHE
LP
VSE
L
W
L
V
D
V
E
GG
K
AKLDI
I
FDL
CQ
R
M
I
D
N
AG
VPM
K
LYK
T
L
D
R
REAL
K
DADFV
TTQL
RVG
Q
L
-
P
A
RELDERIPL
S
HG
Y
LGQ
---
ET
N
G
A
GG
L
FK
GLRTIP
V
I
F
D
IVKD
V
EE
L
CPNAW
VI
N
F
T
NPA
G
MVTEA
V
YR
HT
G
FK
R
F
IG
V
C
N
I
PIG
MKMF
I
H
DV
L
M
L
K
D
SDD
L
S
I
D
LF
GLNHM
---VF
I
K
D
VLVN
G
K
--
S
R
F
A
ELL
DG
V
A
--------------
-
---S
GQ
L
KA
SS
V
KNI
FDLPFSEGLIR
SL
N
L
LP
C
SYL
L
YY
F
K
Q
K
E
-
MLAI
E
MG
E
Y
YK
G
GARAQ
V
V
Q
KV
EKQLFE
L
YK
N
P
----------
E
L
KVKP
KELE
QRGG
A
YYS
D
A
------
AC
EV
INAI
Y
N
--------
D
K
Q
A
EH
YVN
----------------
I
P
H
HG
H
IDN
I
P
ADWA
VEM
T
C
K
L
G
R
D
G
AT
P
H
P
----
R
I
TH
F
DDKVM
GL
I
H
T
IKG
F
E
I
A
AS
NA
A
L
SGEFND
V
LL
A
LN
LSP
---
L
V
H
S
DRD
A
E
L
L
A
R
E
M
I
L
AH
EK
WLP
NF
ADCIAELKKAH
fig|331112.6.peg.1777
Escherichia coli HS
MSQK
L
KVV
T
IGGGS
S
Y
TP
EL
L
E
G
F
I
KRYHE
LP
VSE
L
W
L
V
D
V
E
GG
K
AKLDI
I
FDL
CQ
R
M
I
D
N
AG
VPM
K
LYK
T
L
D
R
REAL
K
DADFV
TTQL
RVG
Q
L
-
P
A
RELDERIPL
S
HG
Y
LGQ
---
ET
N
G
A
GG
L
FK
GLRTIP
V
I
F
D
IVKD
V
EE
L
CPNAW
VI
N
F
T
NPA
G
MVTEA
V
YR
HT
G
FK
R
F
IG
V
C
N
I
PIG
MKMF
I
H
DV
L
M
L
K
D
SDD
L
S
I
D
LF
GLNHM
---VF
I
K
D
VLVN
G
K
--
S
R
F
A
ELL
DG
V
A
--------------
-
---S
GQ
L
KA
SS
V
KNI
FDLPFSEGLIR
SL
N
L
LP
C
SYL
L
YY
F
K
Q
K
E
-
MLAI
E
MG
E
Y
YK
G
GARAQ
V
V
Q
KV
EKQLFE
L
YK
N
P
----------
E
L
KVKP
KELE
QRGG
A
YYS
D
A
------
AC
EV
INAI
Y
N
--------
D
K
Q
A
EH
YVN
----------------
I
P
H
HG
H
IDN
I
P
ADWA
VEM
T
C
K
L
G
R
D
G
AT
P
H
P
----
R
I
TH
F
DDKVM
GL
I
H
T
IKG
F
E
I
A
AS
NA
A
L
SGEFND
V
LL
A
LN
LSP
---
L
V
H
S
DRD
A
E
L
L
A
R
E
M
I
L
AH
EK
WLP
NF
ADCIAELKKAH
fig|316401.4.peg.2027
Escherichia coli ETEC H10407
MSQK
L
KVV
T
IGGGS
S
Y
TP
EL
L
E
G
F
I
KRYHE
LP
VSE
L
W
L
V
D
V
E
GG
K
AKLDI
I
FDL
CQ
R
M
I
D
N
AG
VPM
K
LYK
T
L
D
R
REAL
K
DADFV
TTQL
RVG
Q
L
-
P
A
RELDERIPL
S
HG
Y
LGQ
---
ET
N
G
A
GG
L
FK
GLRTIP
V
I
F
D
IVKD
V
EE
L
CPNAW
VI
N
F
T
NPA
G
MVTEA
V
YR
HT
G
FK
R
F
IG
V
C
N
I
PIG
MKMF
I
R
DV
L
M
L
K
D
SDD
L
S
I
D
LF
GLNHM
---VF
I
K
D
VLVN
G
K
--
S
R
F
A
ELL
DG
V
A
--------------
-
---S
GQ
L
KA
SS
V
KNI
FDLPFSEGLIR
SL
N
L
LP
C
SYL
L
YY
F
K
Q
K
E
-
MLAI
E
MG
E
Y
YK
G
GARAQ
V
V
Q
KV
EKQLFE
L
YK
N
P
----------
E
L
KVKP
KELE
QRGG
A
YYS
D
A
------
AC
EV
INAI
Y
N
--------
D
K
Q
A
EH
YVN
----------------
I
P
H
HG
Q
IDN
I
P
ADWA
VEM
T
C
K
L
G
R
D
G
AT
P
H
P
----
R
I
TH
F
DDKVM
GL
I
H
T
IKG
F
E
I
A
AS
NA
A
L
SGEFND
V
LL
A
LN
LSP
---
L
V
H
S
DRD
A
E
L
L
A
R
E
M
I
L
AH
EK
WLP
NF
ADCIAELKKAH
fig|656414.3.peg.2056
Escherichia coli H736
MSQK
L
KVV
T
IGGGS
S
Y
TP
EL
L
E
G
F
I
KRYHE
LP
VSE
L
W
L
V
D
V
E
GG
K
AKLDI
I
FDL
CQ
R
M
I
D
N
AG
VPM
K
LYK
T
L
D
R
REAL
K
DADFV
TTQL
RVG
Q
L
-
P
A
RELDERIPL
S
HG
Y
LGQ
---
ET
N
G
A
GG
L
FK
GLRTIP
V
I
F
D
IVKD
V
EE
L
CPNAW
VI
N
F
T
NPA
G
MVTEA
V
YR
HT
G
FK
R
F
IG
V
C
N
I
PIG
MKMF
I
R
DV
L
M
L
K
D
SDD
L
S
I
D
LF
GLNHM
---VF
I
K
D
VLVN
G
K
--
S
R
F
A
ELL
DG
V
A
--------------
-
---S
GQ
L
KA
SS
V
KNI
FDLPFSEGLIR
SL
N
L
LP
C
SYL
L
YY
F
K
Q
K
E
-
MLAI
E
MG
E
Y
YK
G
GARAQ
V
V
Q
KV
EKQLFE
L
YK
N
P
----------
E
L
KVKP
KELE
QRGG
A
YYS
D
A
------
AC
EV
INAI
Y
N
--------
D
K
Q
A
EH
YVN
----------------
I
P
H
HG
Q
IDN
I
P
ADWA
VEM
T
C
K
L
G
R
D
G
AT
P
H
P
----
R
I
TH
F
DDKVM
GL
I
H
T
IKG
F
E
I
A
AS
NA
A
L
SGEFND
V
LL
A
LN
LSP
---
L
V
H
S
DRD
A
E
L
L
A
R
E
M
I
L
AH
EK
WLP
NF
ADCIAELKKAH
fig|749540.3.peg.4151
Escherichia coli MS 146-1
MSQK
L
KVV
T
IGGGS
S
Y
TP
EL
L
E
G
F
I
KRYHE
LP
VSE
L
W
L
V
D
V
E
GG
K
AKLDI
I
FDL
CQ
R
M
I
D
N
AG
VPM
K
LYK
T
L
D
R
REAL
K
DADFV
TTQL
RVG
Q
L
-
P
A
RELDERIPL
S
HG
Y
LGQ
---
ET
N
G
A
GG
L
FK
GLRTIP
V
I
F
D
IVKD
V
EE
L
CPNAW
VI
N
F
T
NPA
G
MVTEA
V
YR
HT
G
FK
R
F
IG
V
C
N
I
PIG
MKMF
I
R
DV
L
M
L
K
D
SDD
L
S
I
D
LF
GLNHM
---VF
I
K
D
VLVN
G
K
--
S
R
F
A
ELL
DG
V
A
--------------
-
---S
GQ
L
KA
SS
V
KNI
FDLPFSEGLIR
SL
N
L
LP
C
SYL
L
YY
F
K
Q
K
E
-
MLAI
E
MG
E
Y
YK
G
GARAQ
V
V
Q
KV
EKQLFE
L
YK
N
P
----------
E
L
KVKP
KELE
QRGG
A
YYS
D
A
------
AC
EV
INAI
Y
N
--------
D
K
Q
A
EH
YVN
----------------
I
P
H
HG
Q
IDN
I
P
ADWA
VEM
T
C
K
L
G
R
D
G
AT
P
H
P
----
R
I
TH
F
DDKVM
GL
I
H
T
IKG
F
E
I
A
AS
NA
A
L
SGEFND
V
LL
A
LN
LSP
---
L
V
H
S
DRD
A
E
L
L
A
R
E
M
I
L
AH
EK
WLP
NF
ADCIAELKKAH
fig|749538.3.peg.4339
Escherichia coli MS 116-1
MSQK
L
KVV
T
IGGGS
S
Y
TP
EL
L
E
G
F
I
KRYHE
LP
VSE
L
W
L
V
D
V
E
GG
K
PKLDI
I
FDL
CQ
R
M
I
D
N
AG
VPM
K
LYK
T
L
D
R
REAL
K
DADFV
TTQL
RVG
Q
L
-
P
A
RELDERIPL
S
HG
Y
LGQ
---
ET
N
G
A
GG
L
FK
GLRTIP
V
I
F
D
IVKD
V
EE
L
CPNAW
VI
N
F
T
NPA
G
MVTEA
V
YR
HT
G
FK
R
F
IG
V
C
N
I
PIG
MKMF
I
R
DV
L
M
L
K
D
SDD
L
S
I
D
LF
GLNHM
---VF
I
K
D
VLVN
G
K
--
S
R
F
A
ELL
DG
V
A
--------------
-
---S
GQ
L
KA
SS
V
KNI
FDLPFSEGLIR
SL
N
L
LP
C
SYL
L
YY
F
K
Q
K
E
-
MLAI
E
MG
E
Y
YK
G
GARAQ
V
V
Q
KV
EKQLFE
L
YK
N
P
----------
E
L
KVKP
KELE
QRGG
A
YYS
D
A
------
AC
EV
INAI
Y
N
--------
D
K
Q
A
EH
YVN
----------------
I
P
H
HG
Q
IDN
I
P
ADWA
VEM
T
C
K
L
G
R
D
G
AT
P
H
P
----
R
I
TH
F
DDKVM
GL
I
H
T
IKG
F
E
I
A
AS
NA
A
L
SGEFND
V
LL
A
LN
LSP
---
L
V
H
S
DRD
A
E
L
L
A
R
E
M
I
L
AH
EK
WLP
NF
ADCIAELKKAH
fig|749548.3.peg.2521
Escherichia coli MS 196-1
MSQK
L
KVV
T
IGGGS
S
Y
TP
EL
L
E
G
F
I
KRYHE
LP
VSE
L
W
L
V
D
V
E
GG
K
PKLDI
I
FDL
CQ
R
M
I
D
N
AG
VPM
K
LYK
T
L
D
R
REAL
K
DADFV
TTQL
RVG
Q
L
-
P
A
RELDERIPL
S
HG
Y
LGQ
---
ET
N
G
A
GG
L
FK
GLRTIP
V
I
F
D
IVKD
V
EE
L
CPNAW
VI
N
F
T
NPA
G
MVTEA
V
YR
HT
G
FK
R
F
IG
V
C
N
I
PIG
MKMF
I
R
DV
L
M
L
K
D
SDD
L
S
I
D
LF
GLNHM
---VF
I
K
D
VLVN
G
K
--
S
R
F
A
ELL
DG
V
A
--------------
-
---S
GQ
L
KA
SS
V
KNI
FDLPFSEGLIR
SL
N
L
LP
C
SYL
L
YY
F
K
Q
K
E
-
MLAI
E
MG
E
Y
YK
G
GARAQ
V
V
Q
KV
EKQLFE
L
YK
N
P
----------
E
L
KVKP
KELE
QRGG
A
YYS
D
A
------
AC
EV
INAI
Y
N
--------
D
K
Q
A
EH
YVN
----------------
I
P
H
HG
Q
IDN
I
P
ADWA
VEM
T
C
K
L
G
R
D
G
AT
P
H
P
----
R
I
TH
F
DDKVM
GL
I
H
T
IKG
F
E
I
A
AS
NA
A
L
SGEFND
V
LL
A
LN
LSP
---
L
V
H
S
DRD
A
E
L
L
A
R
E
M
I
L
AH
EK
WLP
NF
ADCIAELKKAH
fig|595496.3.peg.1696
Escherichia coli BW2952
MSQK
L
KVV
T
IGGGS
S
Y
TP
EL
L
E
G
F
I
KRYHE
LP
VSE
L
W
L
V
D
V
E
GG
K
PKLDI
I
FDL
CQ
R
M
I
D
N
AG
VPM
K
LYK
T
L
D
R
REAL
K
DADFV
TTQL
RVG
Q
L
-
P
A
RELDERIPL
S
HG
Y
LGQ
---
ET
N
G
A
GG
L
FK
GLRTIP
V
I
F
D
IVKD
V
EE
L
CPNAW
VI
N
F
T
NPA
G
MVTEA
V
YR
HT
G
FK
R
F
IG
V
C
N
I
PIG
MKMF
I
R
DV
L
M
L
K
D
SDD
L
S
I
D
LF
GLNHM
---VF
I
K
D
VLIN
G
K
--
S
R
F
A
ELL
DG
V
A
--------------
-
---S
GQ
L
KA
SS
V
KNI
FDLPFSEGLIR
SL
N
L
LP
C
SYL
L
YY
F
K
Q
K
E
-
MLAI
E
MG
E
Y
YK
G
GARAQ
V
V
Q
KV
EKQLFE
L
YK
N
P
----------
E
L
KVKP
KELE
QRGG
A
YYS
D
A
------
AC
EV
INAI
Y
N
--------
D
K
Q
A
EH
YVN
----------------
I
P
H
HG
Q
IDN
I
P
ADWA
VEM
T
C
K
L
G
R
D
G
AT
P
H
P
----
R
I
TH
F
DDKVM
GL
I
H
T
IKG
F
E
I
A
AS
NA
A
L
SGEFND
V
LL
A
LN
LSP
---
L
V
H
S
DRD
A
E
L
L
A
R
E
M
I
L
AH
EK
WLP
NF
ADCIAELKKAH
fig|536056.3.peg.2018
Escherichia coli DH1
MSQK
L
KVV
T
IGGGS
S
Y
TP
EL
L
E
G
F
I
KRYHE
LP
VSE
L
W
L
V
D
V
E
GG
K
PKLDI
I
FDL
CQ
R
M
I
D
N
AG
VPM
K
LYK
T
L
D
R
REAL
K
DADFV
TTQL
RVG
Q
L
-
P
A
RELDERIPL
S
HG
Y
LGQ
---
ET
N
G
A
GG
L
FK
GLRTIP
V
I
F
D
IVKD
V
EE
L
CPNAW
VI
N
F
T
NPA
G
MVTEA
V
YR
HT
G
FK
R
F
IG
V
C
N
I
PIG
MKMF
I
R
DV
L
M
L
K
D
SDD
L
S
I
D
LF
GLNHM
---VF
I
K
D
VLIN
G
K
--
S
R
F
A
ELL
DG
V
A
--------------
-
---S
GQ
L
KA
SS
V
KNI
FDLPFSEGLIR
SL
N
L
LP
C
SYL
L
YY
F
K
Q
K
E
-
MLAI
E
MG
E
Y
YK
G
GARAQ
V
V
Q
KV
EKQLFE
L
YK
N
P
----------
E
L
KVKP
KELE
QRGG
A
YYS
D
A
------
AC
EV
INAI
Y
N
--------
D
K
Q
A
EH
YVN
----------------
I
P
H
HG
Q
IDN
I
P
ADWA
VEM
T
C
K
L
G
R
D
G
AT
P
H
P
----
R
I
TH
F
DDKVM
GL
I
H
T
IKG
F
E
I
A
AS
NA
A
L
SGEFND
V
LL
A
LN
LSP
---
L
V
H
S
DRD
A
E
L
L
A
R
E
M
I
L
AH
EK
WLP
NF
ADCIAELKKAH
fig|83333.1.peg.1717
Escherichia coli K12
MSQK
L
KVV
T
IGGGS
S
Y
TP
EL
L
E
G
F
I
KRYHE
LP
VSE
L
W
L
V
D
V
E
GG
K
PKLDI
I
FDL
CQ
R
M
I
D
N
AG
VPM
K
LYK
T
L
D
R
REAL
K
DADFV
TTQL
RVG
Q
L
-
P
A
RELDERIPL
S
HG
Y
LGQ
---
ET
N
G
A
GG
L
FK
GLRTIP
V
I
F
D
IVKD
V
EE
L
CPNAW
VI
N
F
T
NPA
G
MVTEA
V
YR
HT
G
FK
R
F
IG
V
C
N
I
PIG
MKMF
I
R
DV
L
M
L
K
D
SDD
L
S
I
D
LF
GLNHM
---VF
I
K
D
VLIN
G
K
--
S
R
F
A
ELL
DG
V
A
--------------
-
---S
GQ
L
KA
SS
V
KNI
FDLPFSEGLIR
SL
N
L
LP
C
SYL
L
YY
F
K
Q
K
E
-
MLAI
E
MG
E
Y
YK
G
GARAQ
V
V
Q
KV
EKQLFE
L
YK
N
P
----------
E
L
KVKP
KELE
QRGG
A
YYS
D
A
------
AC
EV
INAI
Y
N
--------
D
K
Q
A
EH
YVN
----------------
I
P
H
HG
Q
IDN
I
P
ADWA
VEM
T
C
K
L
G
R
D
G
AT
P
H
P
----
R
I
TH
F
DDKVM
GL
I
H
T
IKG
F
E
I
A
AS
NA
A
L
SGEFND
V
LL
A
LN
LSP
---
L
V
H
S
DRD
A
E
L
L
A
R
E
M
I
L
AH
EK
WLP
NF
ADCIAELKKAH
fig|316407.3.peg.1689
Escherichia coli W3110
MSQK
L
KVV
T
IGGGS
S
Y
TP
EL
L
E
G
F
I
KRYHE
LP
VSE
L
W
L
V
D
V
E
GG
K
PKLDI
I
FDL
CQ
R
M
I
D
N
AG
VPM
K
LYK
T
L
D
R
REAL
K
DADFV
TTQL
RVG
Q
L
-
P
A
RELDERIPL
S
HG
Y
LGQ
---
ET
N
G
A
GG
L
FK
GLRTIP
V
I
F
D
IVKD
V
EE
L
CPNAW
VI
N
F
T
NPA
G
MVTEA
V
YR
HT
G
FK
R
F
IG
V
C
N
I
PIG
MKMF
I
R
DV
L
M
L
K
D
SDD
L
S
I
D
LF
GLNHM
---VF
I
K
D
VLIN
G
K
--
S
R
F
A
ELL
DG
V
A
--------------
-
---S
GQ
L
KA
SS
V
KNI
FDLPFSEGLIR
SL
N
L
LP
C
SYL
L
YY
F
K
Q
K
E
-
MLAI
E
MG
E
Y
YK
G
GARAQ
V
V
Q
KV
EKQLFE
L
YK
N
P
----------
E
L
KVKP
KELE
QRGG
A
YYS
D
A
------
AC
EV
INAI
Y
N
--------
D
K
Q
A
EH
YVN
----------------
I
P
H
HG
Q
IDN
I
P
ADWA
VEM
T
C
K
L
G
R
D
G
AT
P
H
P
----
R
I
TH
F
DDKVM
GL
I
H
T
IKG
F
E
I
A
AS
NA
A
L
SGEFND
V
LL
A
LN
LSP
---
L
V
H
S
DRD
A
E
L
L
A
R
E
M
I
L
AH
EK
WLP
NF
ADCIAELKKAH
fig|316385.5.peg.1850
Escherichia coli str. K-12 substr. DH10B
MSQK
L
KVV
T
IGGGS
S
Y
TP
EL
L
E
G
F
I
KRYHE
LP
VSE
L
W
L
V
D
V
E
GG
K
PKLDI
I
FDL
CQ
R
M
I
D
N
AG
VPM
K
LYK
T
L
D
R
REAL
K
DADFV
TTQL
RVG
Q
L
-
P
A
RELDERIPL
S
HG
Y
LGQ
---
ET
N
G
A
GG
L
FK
GLRTIP
V
I
F
D
IVKD
V
EE
L
CPNAW
VI
N
F
T
NPA
G
MVTEA
V
YR
HT
G
FK
R
F
IG
V
C
N
I
PIG
MKMF
I
R
DV
L
M
L
K
D
SDD
L
S
I
D
LF
GLNHM
---VF
I
K
D
VLIN
G
K
--
S
R
F
A
ELL
DG
V
A
--------------
-
---S
GQ
L
KA
SS
V
KNI
FDLPFSEGLIR
SL
N
L
LP
C
SYL
L
YY
F
K
Q
K
E
-
MLAI
E
MG
E
Y
YK
G
GARAQ
V
V
Q
KV
EKQLFE
L
YK
N
P
----------
E
L
KVKP
KELE
QRGG
A
YYS
D
A
------
AC
EV
INAI
Y
N
--------
D
K
Q
A
EH
YVN
----------------
I
P
H
HG
Q
IDN
I
P
ADWA
VEM
T
C
K
L
G
R
D
G
AT
P
H
P
----
R
I
TH
F
DDKVM
GL
I
H
T
IKG
F
E
I
A
AS
NA
A
L
SGEFND
V
LL
A
LN
LSP
---
L
V
H
S
DRD
A
E
L
L
A
R
E
M
I
L
AH
EK
WLP
NF
ADCIAELKKAH
fig|316385.7.peg.1894
Escherichia coli str. K-12 substr. DH10B
MSQK
L
KVV
T
IGGGS
S
Y
TP
EL
L
E
G
F
I
KRYHE
LP
VSE
L
W
L
V
D
V
E
GG
K
PKLDI
I
FDL
CQ
R
M
I
D
N
AG
VPM
K
LYK
T
L
D
R
REAL
K
DADFV
TTQL
RVG
Q
L
-
P
A
RELDERIPL
S
HG
Y
LGQ
---
ET
N
G
A
GG
L
FK
GLRTIP
V
I
F
D
IVKD
V
EE
L
CPNAW
VI
N
F
T
NPA
G
MVTEA
V
YR
HT
G
FK
R
F
IG
V
C
N
I
PIG
MKMF
I
R
DV
L
M
L
K
D
SDD
L
S
I
D
LF
GLNHM
---VF
I
K
D
VLIN
G
K
--
S
R
F
A
ELL
DG
V
A
--------------
-
---S
GQ
L
KA
SS
V
KNI
FDLPFSEGLIR
SL
N
L
LP
C
SYL
L
YY
F
K
Q
K
E
-
MLAI
E
MG
E
Y
YK
G
GARAQ
V
V
Q
KV
EKQLFE
L
YK
N
P
----------
E
L
KVKP
KELE
QRGG
A
YYS
D
A
------
AC
EV
INAI
Y
N
--------
D
K
Q
A
EH
YVN
----------------
I
P
H
HG
Q
IDN
I
P
ADWA
VEM
T
C
K
L
G
R
D
G
AT
P
H
P
----
R
I
TH
F
DDKVM
GL
I
H
T
IKG
F
E
I
A
AS
NA
A
L
SGEFND
V
LL
A
LN
LSP
---
L
V
H
S
DRD
A
E
L
L
A
R
E
M
I
L
AH
EK
WLP
NF
ADCIAELKKAH
fig|511145.12.peg.1806
Escherichia coli str. K-12 substr. MG1655
MSQK
L
KVV
T
IGGGS
S
Y
TP
EL
L
E
G
F
I
KRYHE
LP
VSE
L
W
L
V
D
V
E
GG
K
PKLDI
I
FDL
CQ
R
M
I
D
N
AG
VPM
K
LYK
T
L
D
R
REAL
K
DADFV
TTQL
RVG
Q
L
-
P
A
RELDERIPL
S
HG
Y
LGQ
---
ET
N
G
A
GG
L
FK
GLRTIP
V
I
F
D
IVKD
V
EE
L
CPNAW
VI
N
F
T
NPA
G
MVTEA
V
YR
HT
G
FK
R
F
IG
V
C
N
I
PIG
MKMF
I
R
DV
L
M
L
K
D
SDD
L
S
I
D
LF
GLNHM
---VF
I
K
D
VLIN
G
K
--
S
R
F
A
ELL
DG
V
A
--------------
-
---S
GQ
L
KA
SS
V
KNI
FDLPFSEGLIR
SL
N
L
LP
C
SYL
L
YY
F
K
Q
K
E
-
MLAI
E
MG
E
Y
YK
G
GARAQ
V
V
Q
KV
EKQLFE
L
YK
N
P
----------
E
L
KVKP
KELE
QRGG
A
YYS
D
A
------
AC
EV
INAI
Y
N
--------
D
K
Q
A
EH
YVN
----------------
I
P
H
HG
Q
IDN
I
P
ADWA
VEM
T
C
K
L
G
R
D
G
AT
P
H
P
----
R
I
TH
F
DDKVM
GL
I
H
T
IKG
F
E
I
A
AS
NA
A
L
SGEFND
V
LL
A
LN
LSP
---
L
V
H
S
DRD
A
E
L
L
A
R
E
M
I
L
AH
EK
WLP
NF
ADCIAELKKAH
fig|511145.6.peg.1791
Escherichia coli str. K-12 substr. MG1655
MSQK
L
KVV
T
IGGGS
S
Y
TP
EL
L
E
G
F
I
KRYHE
LP
VSE
L
W
L
V
D
V
E
GG
K
PKLDI
I
FDL
CQ
R
M
I
D
N
AG
VPM
K
LYK
T
L
D
R
REAL
K
DADFV
TTQL
RVG
Q
L
-
P
A
RELDERIPL
S
HG
Y
LGQ
---
ET
N
G
A
GG
L
FK
GLRTIP
V
I
F
D
IVKD
V
EE
L
CPNAW
VI
N
F
T
NPA
G
MVTEA
V
YR
HT
G
FK
R
F
IG
V
C
N
I
PIG
MKMF
I
R
DV
L
M
L
K
D
SDD
L
S
I
D
LF
GLNHM
---VF
I
K
D
VLIN
G
K
--
S
R
F
A
ELL
DG
V
A
--------------
-
---S
GQ
L
KA
SS
V
KNI
FDLPFSEGLIR
SL
N
L
LP
C
SYL
L
YY
F
K
Q
K
E
-
MLAI
E
MG
E
Y
YK
G
GARAQ
V
V
Q
KV
EKQLFE
L
YK
N
P
----------
E
L
KVKP
KELE
QRGG
A
YYS
D
A
------
AC
EV
INAI
Y
N
--------
D
K
Q
A
EH
YVN
----------------
I
P
H
HG
Q
IDN
I
P
ADWA
VEM
T
C
K
L
G
R
D
G
AT
P
H
P
----
R
I
TH
F
DDKVM
GL
I
H
T
IKG
F
E
I
A
AS
NA
A
L
SGEFND
V
LL
A
LN
LSP
---
L
V
H
S
DRD
A
E
L
L
A
R
E
M
I
L
AH
EK
WLP
NF
ADCIAELKKAH
fig|216592.1.peg.1273
Escherichia coli 042 (24-473/473)
MSQK
L
KVV
T
IGGGS
S
Y
TP
EL
L
E
G
F
I
KRYHE
LP
VSE
L
W
L
V
D
V
E
GG
K
AKLDI
I
FDL
CQ
R
M
I
D
N
AG
VPM
K
LYK
T
L
D
R
REAL
K
DADFV
TTQL
RVG
Q
L
-
P
A
RELDERIPL
S
HG
Y
LGQ
---
ET
N
G
A
GG
L
FK
GLRTIP
V
I
F
D
IVKD
V
EE
L
CPNAW
VI
N
F
T
NPA
G
MVTEA
V
YR
HT
G
FK
R
F
IG
V
C
N
I
PIG
MKMF
I
R
DV
L
M
L
K
D
SDD
L
S
I
D
LF
GLNHM
---VF
I
K
D
VLVN
G
K
--
S
R
F
A
ELL
DG
V
A
--------------
-
---S
GQ
L
KA
SG
V
KNI
FDLPFSEGLIR
SL
N
L
LP
C
SYL
L
YY
F
K
Q
K
E
-
MLAI
E
MG
E
Y
YK
G
GARAQ
V
V
Q
KV
EKQLFE
L
YK
N
P
----------
E
L
KVKP
KELE
QRGG
A
YYS
D
A
------
AC
EV
INAI
Y
N
--------
D
K
Q
A
EH
YVN
----------------
I
P
H
HG
H
IDN
I
P
ADWA
VEM
T
C
T
L
G
R
D
G
AT
P
H
P
----
R
I
TH
F
DDKVM
GL
I
H
T
IKG
F
E
I
A
AS
NA
A
L
SGEFND
V
LL
A
LN
LSP
---
L
V
H
S
DRD
A
E
L
L
A
R
E
M
I
L
AH
EK
WLP
NF
ADCIAELKKAH
fig|216592.3.peg.1974
Escherichia coli 042
MSQK
L
KVV
T
IGGGS
S
Y
TP
EL
L
E
G
F
I
KRYHE
LP
VSE
L
W
L
V
D
V
E
GG
K
AKLDI
I
FDL
CQ
R
M
I
D
N
AG
VPM
K
LYK
T
L
D
R
REAL
K
DADFV
TTQL
RVG
Q
L
-
P
A
RELDERIPL
S
HG
Y
LGQ
---
ET
N
G
A
GG
L
FK
GLRTIP
V
I
F
D
IVKD
V
EE
L
CPNAW
VI
N
F
T
NPA
G
MVTEA
V
YR
HT
G
FK
R
F
IG
V
C
N
I
PIG
MKMF
I
R
DV
L
M
L
K
D
SDD
L
S
I
D
LF
GLNHM
---VF
I
K
D
VLVN
G
K
--
S
R
F
A
ELL
DG
V
A
--------------
-
---S
GQ
L
KA
SG
V
KNI
FDLPFSEGLIR
SL
N
L
LP
C
SYL
L
YY
F
K
Q
K
E
-
MLAI
E
MG
E
Y
YK
G
GARAQ
V
V
Q
KV
EKQLFE
L
YK
N
P
----------
E
L
KVKP
KELE
QRGG
A
YYS
D
A
------
AC
EV
INAI
Y
N
--------
D
K
Q
A
EH
YVN
----------------
I
P
H
HG
H
IDN
I
P
ADWA
VEM
T
C
T
L
G
R
D
G
AT
P
H
P
----
R
I
TH
F
DDKVM
GL
I
H
T
IKG
F
E
I
A
AS
NA
A
L
SGEFND
V
LL
A
LN
LSP
---
L
V
H
S
DRD
A
E
L
L
A
R
E
M
I
L
AH
EK
WLP
NF
ADCIAELKKAH
fig|562.371.peg.4590
Escherichia coli 1044A
MSQK
L
KVV
T
IGGGS
S
Y
TP
EL
L
E
G
F
I
KRYHE
LP
VSE
L
W
L
V
D
V
E
GG
K
AKLDI
I
FDL
CQ
R
M
I
D
N
AG
VPM
K
LYK
T
L
D
R
REAL
K
DADFV
TTQL
RVG
Q
L
-
P
A
RELDERIPL
S
HG
Y
LGQ
---
ET
N
G
A
GG
L
FK
GLRTIP
V
I
F
D
IVKD
V
EE
L
CPNAW
VI
N
F
T
NPA
G
MVTEA
V
YR
HT
G
FK
R
F
IG
V
C
N
I
PIG
MKMF
I
R
DV
L
M
L
K
D
SDD
L
S
I
D
LF
GLNHM
---VF
I
K
D
VLVN
G
K
--
S
R
F
A
ELL
DG
V
A
--------------
-
---S
GQ
L
KA
SG
V
KNI
FDLPFSEGLIR
SL
N
L
LP
C
SYL
L
YY
F
K
Q
K
E
-
MLAI
E
MG
E
Y
YK
G
GARAQ
V
V
Q
KV
EKQLFE
L
YK
N
P
----------
E
L
KVKP
KELE
QRGG
A
YYS
D
A
------
AC
EV
INAI
Y
N
--------
D
K
Q
A
EH
YVN
----------------
I
P
H
HG
H
IDN
I
P
ADWA
VEM
T
C
T
L
G
R
D
G
AT
P
H
P
----
R
I
TH
F
DDKVM
GL
I
H
T
IKG
F
E
I
A
AS
NA
A
L
SGEFND
V
LL
A
LN
LSP
---
L
V
H
S
DRD
A
E
L
L
A
R
E
M
I
L
AH
EK
WLP
NF
ADCIAELKKAH
fig|562.373.peg.5492
Escherichia coli 1125A
MSQK
L
KVV
T
IGGGS
S
Y
TP
EL
L
E
G
F
I
KRYHE
LP
VSE
L
W
L
V
D
V
E
GG
K
AKLDI
I
FDL
CQ
R
M
I
D
N
AG
VPM
K
LYK
T
L
D
R
REAL
K
DADFV
TTQL
RVG
Q
L
-
P
A
RELDERIPL
S
HG
Y
LGQ
---
ET
N
G
A
GG
L
FK
GLRTIP
V
I
F
D
IVKD
V
EE
L
CPNAW
VI
N
F
T
NPA
G
MVTEA
V
YR
HT
G
FK
R
F
IG
V
C
N
I
PIG
MKMF
I
R
DV
L
M
L
K
D
SDD
L
S
I
D
LF
GLNHM
---VF
I
K
D
VLVN
G
K
--
S
R
F
A
ELL
DG
V
A
--------------
-
---S
GQ
L
KA
SG
V
KNI
FDLPFSEGLIR
SL
N
L
LP
C
SYL
L
YY
F
K
Q
K
E
-
MLAI
E
MG
E
Y
YK
G
GARAQ
V
V
Q
KV
EKQLFE
L
YK
N
P
----------
E
L
KVKP
KELE
QRGG
A
YYS
D
A
------
AC
EV
INAI
Y
N
--------
D
K
Q
A
EH
YVN
----------------
I
P
H
HG
H
IDN
I
P
ADWA
VEM
T
C
T
L
G
R
D
G
AT
P
H
P
----
R
I
TH
F
DDKVM
GL
I
H
T
IKG
F
E
I
A
AS
NA
A
L
SGEFND
V
LL
A
LN
LSP
---
L
V
H
S
DRD
A
E
L
L
A
R
E
M
I
L
AH
EK
WLP
NF
ADCIAELKKAH
fig|550677.3.peg.1225
Escherichia coli B354
MSQK
L
KVV
T
IGGGS
S
Y
TP
EL
L
E
G
F
I
KRYHE
LP
VSE
L
W
L
V
D
V
E
GG
K
AKLDI
I
FDL
CQ
R
M
I
D
N
AG
VPM
K
LYK
T
L
D
R
REAL
K
DADFV
TTQL
RVG
Q
L
-
P
A
RELDERIPL
S
HG
Y
LGQ
---
ET
N
G
A
GG
L
FK
GLRTIP
V
I
F
D
IVKD
V
EE
L
CPNAW
VI
N
F
T
NPA
G
MVTEA
V
YR
HT
G
FK
R
F
IG
V
C
N
I
PIG
MKMF
I
R
DV
L
M
L
K
D
SDD
L
S
I
D
LF
GLNHM
---VF
I
K
D
VLVN
G
K
--
S
R
F
A
ELL
DG
V
A
--------------
-
---S
GQ
L
KA
SG
V
KNI
FDLPFSEGLIR
SL
N
L
LP
C
SYL
L
YY
F
K
Q
K
E
-
MLAI
E
MG
E
Y
YK
G
GARAQ
V
V
Q
KV
EKQLFE
L
YK
N
P
----------
E
L
KVKP
KELE
QRGG
A
YYS
D
A
------
AC
EV
INAI
Y
N
--------
D
K
Q
A
EH
YVN
----------------
I
P
H
HG
H
IDN
I
P
ADWA
VEM
T
C
T
L
G
R
D
G
AT
P
H
P
----
R
I
TH
F
DDKVM
GL
I
H
T
IKG
F
E
I
A
AS
NA
A
L
SGEFND
V
LL
A
LN
LSP
---
L
V
H
S
DRD
A
E
L
L
A
R
E
M
I
L
AH
EK
WLP
NF
ADCIAELKKAH
fig|656417.3.peg.2239
Escherichia coli M605
MSQK
L
KVV
T
IGGGS
S
Y
TP
EL
L
E
G
F
I
KRYHE
LP
VSE
L
W
L
V
D
V
E
GG
K
AKLDI
I
FDL
CQ
R
M
I
D
N
AG
VPM
K
LYK
T
L
D
R
REAL
K
DADFV
TTQL
RVG
Q
L
-
P
A
RELDERIPL
S
HG
Y
LGQ
---
ET
N
G
A
GG
L
FK
GLRTIP
V
I
F
D
IVKD
V
EE
L
CPNAW
VI
N
F
T
NPA
G
MVTEA
V
YR
HT
G
FK
R
F
IG
V
C
N
I
PIG
MKMF
I
R
DV
L
M
L
K
D
SDD
L
S
I
D
LF
GLNHM
---VF
I
K
D
VLVN
G
K
--
S
R
F
A
ELL
DG
V
A
--------------
-
---S
GQ
L
KA
SG
V
KNI
FDLPFSEGLIR
SL
N
L
LP
C
SYL
L
YY
F
K
Q
K
E
-
MLAI
E
MG
E
Y
YK
G
GARAQ
V
V
Q
KV
EKQLFE
L
YK
N
P
----------
E
L
KVKP
KELE
QRGG
A
YYS
D
A
------
AC
EV
INAI
Y
N
--------
D
K
Q
A
EH
YVN
----------------
I
P
H
HG
H
IDN
I
P
ADWA
VEM
T
C
T
L
G
R
D
G
AT
P
H
P
----
R
I
TH
F
DDKVM
GL
I
H
T
IKG
F
E
I
A
AS
NA
A
L
SGEFND
V
LL
A
LN
LSP
---
L
V
H
S
DRD
A
E
L
L
A
R
E
M
I
L
AH
EK
WLP
NF
ADCIAELKKAH
fig|83334.1.peg.2466
Escherichia coli O157:H7
MSQK
L
KVV
T
IGGGS
S
Y
TP
EL
L
E
G
F
I
KRYHE
LP
VSE
L
W
L
V
D
V
E
GG
K
AKLDI
I
FDL
CQ
R
M
I
D
N
AG
VPM
K
LYK
T
L
D
R
REAL
K
DADFV
TTQL
RVG
Q
L
-
P
A
RELDERIPL
S
HG
Y
LGQ
---
ET
N
G
A
GG
L
FK
GLRTIP
V
I
F
D
IVKD
V
EE
L
CPNAW
VI
N
F
T
NPA
G
MVTEA
V
YR
HT
G
FK
R
F
IG
V
C
N
I
PIG
MKMF
I
R
DV
L
M
L
K
D
SDD
L
S
I
D
LF
GLNHM
---VF
I
K
D
VLVN
G
K
--
S
R
F
A
ELL
DG
V
A
--------------
-
---S
GQ
L
KA
SG
V
KNI
FDLPFSEGLIR
SL
N
L
LP
C
SYL
L
YY
F
K
Q
K
E
-
MLAI
E
MG
E
Y
YK
G
GARAQ
V
V
Q
KV
EKQLFE
L
YK
N
P
----------
E
L
KVKP
KELE
QRGG
A
YYS
D
A
------
AC
EV
INAI
Y
N
--------
D
K
Q
A
EH
YVN
----------------
I
P
H
HG
H
IDN
I
P
ADWA
VEM
T
C
T
L
G
R
D
G
AT
P
H
P
----
R
I
TH
F
DDKVM
GL
I
H
T
IKG
F
E
I
A
AS
NA
A
L
SGEFND
V
LL
A
LN
LSP
---
L
V
H
S
DRD
A
E
L
L
A
R
E
M
I
L
AH
EK
WLP
NF
ADCIAELKKAH
fig|155864.1.peg.2475
Escherichia coli O157:H7 EDL933
MSQK
L
KVV
T
IGGGS
S
Y
TP
EL
L
E
G
F
I
KRYHE
LP
VSE
L
W
L
V
D
V
E
GG
K
AKLDI
I
FDL
CQ
R
M
I
D
N
AG
VPM
K
LYK
T
L
D
R
REAL
K
DADFV
TTQL
RVG
Q
L
-
P
A
RELDERIPL
S
HG
Y
LGQ
---
ET
N
G
A
GG
L
FK
GLRTIP
V
I
F
D
IVKD
V
EE
L
CPNAW
VI
N
F
T
NPA
G
MVTEA
V
YR
HT
G
FK
R
F
IG
V
C
N
I
PIG
MKMF
I
R
DV
L
M
L
K
D
SDD
L
S
I
D
LF
GLNHM
---VF
I
K
D
VLVN
G
K
--
S
R
F
A
ELL
DG
V
A
--------------
-
---S
GQ
L
KA
SG
V
KNI
FDLPFSEGLIR
SL
N
L
LP
C
SYL
L
YY
F
K
Q
K
E
-
MLAI
E
MG
E
Y
YK
G
GARAQ
V
V
Q
KV
EKQLFE
L
YK
N
P
----------
E
L
KVKP
KELE
QRGG
A
YYS
D
A
------
AC
EV
INAI
Y
N
--------
D
K
Q
A
EH
YVN
----------------
I
P
H
HG
H
IDN
I
P
ADWA
VEM
T
C
T
L
G
R
D
G
AT
P
H
P
----
R
I
TH
F
DDKVM
GL
I
H
T
IKG
F
E
I
A
AS
NA
A
L
SGEFND
V
LL
A
LN
LSP
---
L
V
H
S
DRD
A
E
L
L
A
R
E
M
I
L
AH
EK
WLP
NF
ADCIAELKKAH
fig|155864.8.peg.2323
Escherichia coli O157:H7 EDL933
MSQK
L
KVV
T
IGGGS
S
Y
TP
EL
L
E
G
F
I
KRYHE
LP
VSE
L
W
L
V
D
V
E
GG
K
AKLDI
I
FDL
CQ
R
M
I
D
N
AG
VPM
K
LYK
T
L
D
R
REAL
K
DADFV
TTQL
RVG
Q
L
-
P
A
RELDERIPL
S
HG
Y
LGQ
---
ET
N
G
A
GG
L
FK
GLRTIP
V
I
F
D
IVKD
V
EE
L
CPNAW
VI
N
F
T
NPA
G
MVTEA
V
YR
HT
G
FK
R
F
IG
V
C
N
I
PIG
MKMF
I
R
DV
L
M
L
K
D
SDD
L
S
I
D
LF
GLNHM
---VF
I
K
D
VLVN
G
K
--
S
R
F
A
ELL
DG
V
A
--------------
-
---S
GQ
L
KA
SG
V
KNI
FDLPFSEGLIR
SL
N
L
LP
C
SYL
L
YY
F
K
Q
K
E
-
MLAI
E
MG
E
Y
YK
G
GARAQ
V
V
Q
KV
EKQLFE
L
YK
N
P
----------
E
L
KVKP
KELE
QRGG
A
YYS
D
A
------
AC
EV
INAI
Y
N
--------
D
K
Q
A
EH
YVN
----------------
I
P
H
HG
H
IDN
I
P
ADWA
VEM
T
C
T
L
G
R
D
G
AT
P
H
P
----
R
I
TH
F
DDKVM
GL
I
H
T
IKG
F
E
I
A
AS
NA
A
L
SGEFND
V
LL
A
LN
LSP
---
L
V
H
S
DRD
A
E
L
L
A
R
E
M
I
L
AH
EK
WLP
NF
ADCIAELKKAH
fig|478006.5.peg.2658
Escherichia coli O157:H7 str. EC4501
MSQK
L
KVV
T
IGGGS
S
Y
TP
EL
L
E
G
F
I
KRYHE
LP
VSE
L
W
L
V
D
V
E
GG
K
AKLDI
I
FDL
CQ
R
M
I
D
N
AG
VPM
K
LYK
T
L
D
R
REAL
K
DADFV
TTQL
RVG
Q
L
-
P
A
RELDERIPL
S
HG
Y
LGQ
---
ET
N
G
A
GG
L
FK
GLRTIP
V
I
F
D
IVKD
V
EE
L
CPNAW
VI
N
F
T
NPA
G
MVTEA
V
YR
HT
G
FK
R
F
IG
V
C
N
I
PIG
MKMF
I
R
DV
L
M
L
K
D
SDD
L
S
I
D
LF
GLNHM
---VF
I
K
D
VLVN
G
K
--
S
R
F
A
ELL
DG
V
A
--------------
-
---S
GQ
L
KA
SG
V
KNI
FDLPFSEGLIR
SL
N
L
LP
C
SYL
L
YY
F
K
Q
K
E
-
MLAI
E
MG
E
Y
YK
G
GARAQ
V
V
Q
KV
EKQLFE
L
YK
N
P
----------
E
L
KVKP
KELE
QRGG
A
YYS
D
A
------
AC
EV
INAI
Y
N
--------
D
K
Q
A
EH
YVN
----------------
I
P
H
HG
H
IDN
I
P
ADWA
VEM
T
C
T
L
G
R
D
G
AT
P
H
P
----
R
I
TH
F
DDKVM
GL
I
H
T
IKG
F
E
I
A
AS
NA
A
L
SGEFND
V
LL
A
LN
LSP
---
L
V
H
S
DRD
A
E
L
L
A
R
E
M
I
L
AH
EK
WLP
NF
ADCIAELKKAH
fig|478007.5.peg.2777
Escherichia coli O157:H7 str. EC508
MSQK
L
KVV
T
IGGGS
S
Y
TP
EL
L
E
G
F
I
KRYHE
LP
VSE
L
W
L
V
D
V
E
GG
K
AKLDI
I
FDL
CQ
R
M
I
D
N
AG
VPM
K
LYK
T
L
D
R
REAL
K
DADFV
TTQL
RVG
Q
L
-
P
A
RELDERIPL
S
HG
Y
LGQ
---
ET
N
G
A
GG
L
FK
GLRTIP
V
I
F
D
IVKD
V
EE
L
CPNAW
VI
N
F
T
NPA
G
MVTEA
V
YR
HT
G
FK
R
F
IG
V
C
N
I
PIG
MKMF
I
R
DV
L
M
L
K
D
SDD
L
S
I
D
LF
GLNHM
---VF
I
K
D
VLVN
G
K
--
S
R
F
A
ELL
DG
V
A
--------------
-
---S
GQ
L
KA
SG
V
KNI
FDLPFSEGLIR
SL
N
L
LP
C
SYL
L
YY
F
K
Q
K
E
-
MLAI
E
MG
E
Y
YK
G
GARAQ
V
V
Q
KV
EKQLFE
L
YK
N
P
----------
E
L
KVKP
KELE
QRGG
A
YYS
D
A
------
AC
EV
INAI
Y
N
--------
D
K
Q
A
EH
YVN
----------------
I
P
H
HG
H
IDN
I
P
ADWA
VEM
T
C
T
L
G
R
D
G
AT
P
H
P
----
R
I
TH
F
DDKVM
GL
I
H
T
IKG
F
E
I
A
AS
NA
A
L
SGEFND
V
LL
A
LN
LSP
---
L
V
H
S
DRD
A
E
L
L
A
R
E
M
I
L
AH
EK
WLP
NF
ADCIAELKKAH
fig|478008.5.peg.3330
Escherichia coli O157:H7 str. EC869
MSQK
L
KVV
T
IGGGS
S
Y
TP
EL
L
E
G
F
I
KRYHE
LP
VSE
L
W
L
V
D
V
E
GG
K
AKLDI
I
FDL
CQ
R
M
I
D
N
AG
VPM
K
LYK
T
L
D
R
REAL
K
DADFV
TTQL
RVG
Q
L
-
P
A
RELDERIPL
S
HG
Y
LGQ
---
ET
N
G
A
GG
L
FK
GLRTIP
V
I
F
D
IVKD
V
EE
L
CPNAW
VI
N
F
T
NPA
G
MVTEA
V
YR
HT
G
FK
R
F
IG
V
C
N
I
PIG
MKMF
I
R
DV
L
M
L
K
D
SDD
L
S
I
D
LF
GLNHM
---VF
I
K
D
VLVN
G
K
--
S
R
F
A
ELL
DG
V
A
--------------
-
---S
GQ
L
KA
SG
V
KNI
FDLPFSEGLIR
SL
N
L
LP
C
SYL
L
YY
F
K
Q
K
E
-
MLAI
E
MG
E
Y
YK
G
GARAQ
V
V
Q
KV
EKQLFE
L
YK
N
P
----------
E
L
KVKP
KELE
QRGG
A
YYS
D
A
------
AC
EV
INAI
Y
N
--------
D
K
Q
A
EH
YVN
----------------
I
P
H
HG
H
IDN
I
P
ADWA
VEM
T
C
T
L
G
R
D
G
AT
P
H
P
----
R
I
TH
F
DDKVM
GL
I
H
T
IKG
F
E
I
A
AS
NA
A
L
SGEFND
V
LL
A
LN
LSP
---
L
V
H
S
DRD
A
E
L
L
A
R
E
M
I
L
AH
EK
WLP
NF
ADCIAELKKAH
fig|637388.3.peg.4858
Escherichia coli O157:H7 str. FRIK2000
MSQK
L
KVV
T
IGGGS
S
Y
TP
EL
L
E
G
F
I
KRYHE
LP
VSE
L
W
L
V
D
V
E
GG
K
AKLDI
I
FDL
CQ
R
M
I
D
N
AG
VPM
K
LYK
T
L
D
R
REAL
K
DADFV
TTQL
RVG
Q
L
-
P
A
RELDERIPL
S
HG
Y
LGQ
---
ET
N
G
A
GG
L
FK
GLRTIP
V
I
F
D
IVKD
V
EE
L
CPNAW
VI
N
F
T
NPA
G
MVTEA
V
YR
HT
G
FK
R
F
IG
V
C
N
I
PIG
MKMF
I
R
DV
L
M
L
K
D
SDD
L
S
I
D
LF
GLNHM
---VF
I
K
D
VLVN
G
K
--
S
R
F
A
ELL
DG
V
A
--------------
-
---S
GQ
L
KA
SG
V
KNI
FDLPFSEGLIR
SL
N
L
LP
C
SYL
L
YY
F
K
Q
K
E
-
MLAI
E
MG
E
Y
YK
G
GARAQ
V
V
Q
KV
EKQLFE
L
YK
N
P
----------
E
L
KVKP
KELE
QRGG
A
YYS
D
A
------
AC
EV
INAI
Y
N
--------
D
K
Q
A
EH
YVN
----------------
I
P
H
HG
H
IDN
I
P
ADWA
VEM
T
C
T
L
G
R
D
G
AT
P
H
P
----
R
I
TH
F
DDKVM
GL
I
H
T
IKG
F
E
I
A
AS
NA
A
L
SGEFND
V
LL
A
LN
LSP
---
L
V
H
S
DRD
A
E
L
L
A
R
E
M
I
L
AH
EK
WLP
NF
ADCIAELKKAH
fig|570506.3.peg.3947
Escherichia coli O157:H7 str. FRIK966
MSQK
L
KVV
T
IGGGS
S
Y
TP
EL
L
E
G
F
I
KRYHE
LP
VSE
L
W
L
V
D
V
E
GG
K
AKLDI
I
FDL
CQ
R
M
I
D
N
AG
VPM
K
LYK
T
L
D
R
REAL
K
DADFV
TTQL
RVG
Q
L
-
P
A
RELDERIPL
S
HG
Y
LGQ
---
ET
N
G
A
GG
L
FK
GLRTIP
V
I
F
D
IVKD
V
EE
L
CPNAW
VI
N
F
T
NPA
G
MVTEA
V
YR
HT
G
FK
R
F
IG
V
C
N
I
PIG
MKMF
I
R
DV
L
M
L
K
D
SDD
L
S
I
D
LF
GLNHM
---VF
I
K
D
VLVN
G
K
--
S
R
F
A
ELL
DG
V
A
--------------
-
---S
GQ
L
KA
SG
V
KNI
FDLPFSEGLIR
SL
N
L
LP
C
SYL
L
YY
F
K
Q
K
E
-
MLAI
E
MG
E
Y
YK
G
GARAQ
V
V
Q
KV
EKQLFE
L
YK
N
P
----------
E
L
KVKP
KELE
QRGG
A
YYS
D
A
------
AC
EV
INAI
Y
N
--------
D
K
Q
A
EH
YVN
----------------
I
P
H
HG
H
IDN
I
P
ADWA
VEM
T
C
T
L
G
R
D
G
AT
P
H
P
----
R
I
TH
F
DDKVM
GL
I
H
T
IKG
F
E
I
A
AS
NA
A
L
SGEFND
V
LL
A
LN
LSP
---
L
V
H
S
DRD
A
E
L
L
A
R
E
M
I
L
AH
EK
WLP
NF
ADCIAELKKAH
fig|386585.9.peg.2554
Escherichia coli O157:H7 str. Sakai
MSQK
L
KVV
T
IGGGS
S
Y
TP
EL
L
E
G
F
I
KRYHE
LP
VSE
L
W
L
V
D
V
E
GG
K
AKLDI
I
FDL
CQ
R
M
I
D
N
AG
VPM
K
LYK
T
L
D
R
REAL
K
DADFV
TTQL
RVG
Q
L
-
P
A
RELDERIPL
S
HG
Y
LGQ
---
ET
N
G
A
GG
L
FK
GLRTIP
V
I
F
D
IVKD
V
EE
L
CPNAW
VI
N
F
T
NPA
G
MVTEA
V
YR
HT
G
FK
R
F
IG
V
C
N
I
PIG
MKMF
I
R
DV
L
M
L
K
D
SDD
L
S
I
D
LF
GLNHM
---VF
I
K
D
VLVN
G
K
--
S
R
F
A
ELL
DG
V
A
--------------
-
---S
GQ
L
KA
SG
V
KNI
FDLPFSEGLIR
SL
N
L
LP
C
SYL
L
YY
F
K
Q
K
E
-
MLAI
E
MG
E
Y
YK
G
GARAQ
V
V
Q
KV
EKQLFE
L
YK
N
P
----------
E
L
KVKP
KELE
QRGG
A
YYS
D
A
------
AC
EV
INAI
Y
N
--------
D
K
Q
A
EH
YVN
----------------
I
P
H
HG
H
IDN
I
P
ADWA
VEM
T
C
T
L
G
R
D
G
AT
P
H
P
----
R
I
TH
F
DDKVM
GL
I
H
T
IKG
F
E
I
A
AS
NA
A
L
SGEFND
V
LL
A
LN
LSP
---
L
V
H
S
DRD
A
E
L
L
A
R
E
M
I
L
AH
EK
WLP
NF
ADCIAELKKAH
fig|502346.5.peg.4960
Escherichia coli O157:H7 str. TW14588
MSQK
L
KVV
T
IGGGS
S
Y
TP
EL
L
E
G
F
I
KRYHE
LP
VSE
L
W
L
V
D
V
E
GG
K
AKLDI
I
FDL
CQ
R
M
I
D
N
AG
VPM
K
LYK
T
L
D
R
REAL
K
DADFV
TTQL
RVG
Q
L
-
P
A
RELDERIPL
S
HG
Y
LGQ
---
ET
N
G
A
GG
L
FK
GLRTIP
V
I
F
D
IVKD
V
EE
L
CPNAW
VI
N
F
T
NPA
G
MVTEA
V
YR
HT
G
FK
R
F
IG
V
C
N
I
PIG
MKMF
I
R
DV
L
M
L
K
D
SDD
L
S
I
D
LF
GLNHM
---VF
I
K
D
VLVN
G
K
--
S
R
F
A
ELL
DG
V
A
--------------
-
---S
GQ
L
KA
SG
V
KNI
FDLPFSEGLIR
SL
N
L
LP
C
SYL
L
YY
F
K
Q
K
E
-
MLAI
E
MG
E
Y
YK
G
GARAQ
V
V
Q
KV
EKQLFE
L
YK
N
P
----------
E
L
KVKP
KELE
QRGG
A
YYS
D
A
------
AC
EV
INAI
Y
N
--------
D
K
Q
A
EH
YVN
----------------
I
P
H
HG
H
IDN
I
P
ADWA
VEM
T
C
T
L
G
R
D
G
AT
P
H
P
----
R
I
TH
F
DDKVM
GL
I
H
T
IKG
F
E
I
A
AS
NA
A
L
SGEFND
V
LL
A
LN
LSP
---
L
V
H
S
DRD
A
E
L
L
A
R
E
M
I
L
AH
EK
WLP
NF
ADCIAELKKAH
fig|701177.3.peg.2182
Escherichia coli O55:H7 str. CB9615
MSQK
L
KVV
T
IGGGS
S
Y
TP
EL
L
E
G
F
I
KRYHE
LP
VSE
L
W
L
V
D
V
E
GG
K
AKLDI
I
FDL
CQ
R
M
I
D
N
AG
VPM
K
LYK
T
L
D
R
REAL
K
DADFV
TTQL
RVG
Q
L
-
P
A
RELDERIPL
S
HG
Y
LGQ
---
ET
N
G
A
GG
L
FK
GLRTIP
V
I
F
D
IVKD
V
EE
L
CPNAW
VI
N
F
T
NPA
G
MVTEA
V
YR
HT
G
FK
R
F
IG
V
C
N
I
PIG
MKMF
I
R
DV
L
M
L
K
D
SDD
L
S
I
D
LF
GLNHM
---VF
I
K
D
VLVN
G
K
--
S
R
F
A
ELL
DG
V
A
--------------
-
---S
GQ
L
KA
SG
V
KNI
FDLPFSEGLIR
SL
N
L
LP
C
SYL
L
YY
F
K
Q
K
E
-
MLAI
E
MG
E
Y
YK
G
GARAQ
V
V
Q
KV
EKQLFE
L
YK
N
P
----------
E
L
KVKP
KELE
QRGG
A
YYS
D
A
------
AC
EV
INAI
Y
N
--------
D
K
Q
A
EH
YVN
----------------
I
P
H
HG
H
IDN
I
P
ADWA
VEM
T
C
T
L
G
R
D
G
AT
P
H
P
----
R
I
TH
F
DDKVM
GL
I
H
T
IKG
F
E
I
A
AS
NA
A
L
SGEFND
V
LL
A
LN
LSP
---
L
V
H
S
DRD
A
E
L
L
A
R
E
M
I
L
AH
EK
WLP
NF
ADCIAELKKAH
fig|431946.3.peg.1655
Escherichia coli SE15
MSQK
L
KVV
T
IGGGS
S
Y
TP
EL
L
E
G
F
I
KRYHE
LP
VSE
L
W
L
V
D
V
E
GG
K
AKLDI
I
FDL
CQ
R
M
I
D
N
AG
VPM
K
LYK
T
L
D
R
REAL
K
DADFV
TTQL
RVG
Q
L
-
P
A
RELDERIPL
S
HG
Y
LGQ
---
ET
N
G
A
GG
L
FK
GLRTIP
V
I
F
D
IVKD
V
EE
L
CPNAW
VI
N
F
T
NPA
G
MVTEA
V
YR
HT
G
FK
R
F
IG
V
C
N
I
PIG
MKMF
I
R
DV
L
M
L
K
D
SDD
L
S
I
D
LF
GLNHM
---VF
I
K
D
VLVN
G
K
--
S
R
F
A
ELL
DG
V
A
--------------
-
---S
GQ
L
KA
SG
V
KNI
FDLPFSEGLIR
SL
N
L
LP
C
SYL
L
YY
F
K
Q
K
E
-
MLAI
E
MG
E
Y
YK
G
GARAQ
V
V
Q
KV
EKQLFE
L
YK
N
P
----------
E
L
KVKP
KELE
QRGG
A
YYS
D
A
------
AC
EV
INAI
Y
N
--------
D
K
Q
A
EH
YVN
----------------
I
P
H
HG
H
IDN
I
P
ADWA
VEM
T
C
T
L
G
R
D
G
AT
P
H
P
----
R
I
TH
F
DDKVM
GL
I
H
T
IKG
F
E
I
A
AS
NA
A
L
SGEFND
V
LL
A
LN
LSP
---
L
V
H
S
DRD
A
E
L
L
A
R
E
M
I
L
AH
EK
WLP
NF
ADCIAELKKAH
fig|656437.3.peg.1961
Escherichia coli TA143
MSQK
L
KVV
T
IGGGS
S
Y
TP
EL
L
E
G
F
I
KRYHE
LP
VSE
L
W
L
V
D
V
E
GG
K
AKLDI
I
FDL
CQ
R
M
I
D
N
AG
VPM
K
LYK
T
L
D
R
REAL
K
DADFV
TTQL
RVG
Q
L
-
P
A
RELDERIPL
S
HG
Y
LGQ
---
ET
N
G
A
GG
L
FK
GLRTIP
V
I
F
D
IVKD
V
EE
L
CPNAW
VI
N
F
T
NPA
G
MVTEA
V
YR
HT
G
FK
R
F
IG
V
C
N
I
PIG
MKMF
I
R
DV
L
M
L
K
D
SDD
L
S
I
D
LF
GLNHM
---VF
I
K
D
VLVN
G
K
--
S
R
F
A
ELL
DG
V
A
--------------
-
---S
GQ
L
KA
SG
V
KNI
FDLPFSEGLIR
SL
N
L
LP
C
SYL
L
YY
F
K
Q
K
E
-
MLAI
E
MG
E
Y
YK
G
GARAQ
V
V
Q
KV
EKQLFE
L
YK
N
P
----------
E
L
KVKP
KELE
QRGG
A
YYS
D
A
------
AC
EV
INAI
Y
N
--------
D
K
Q
A
EH
YVN
----------------
I
P
H
HG
H
IDN
I
P
ADWA
VEM
T
C
T
L
G
R
D
G
AT
P
H
P
----
R
I
TH
F
DDKVM
GL
I
H
T
IKG
F
E
I
A
AS
NA
A
L
SGEFND
V
LL
A
LN
LSP
---
L
V
H
S
DRD
A
E
L
L
A
R
E
M
I
L
AH
EK
WLP
NF
ADCIAELKKAH
fig|656444.3.peg.2643
Escherichia coli TA280
MSQK
L
KVV
T
IGGGS
S
Y
TP
EL
L
E
G
F
I
KRYHE
LP
VSE
L
W
L
V
D
V
E
GG
K
AKLDI
I
FDL
CQ
R
M
I
D
N
AG
VPM
K
LYK
T
L
D
R
REAL
K
DADFV
TTQL
RVG
Q
L
-
P
A
RELDERIPL
S
HG
Y
LGQ
---
ET
N
G
A
GG
L
FK
GLRTIP
V
I
F
D
IVKD
V
EE
L
CPNAW
VI
N
F
T
NPA
G
MVTEA
V
YR
HT
G
FK
R
F
IG
V
C
N
I
PIG
MKMF
I
R
DV
L
M
L
K
D
SDD
L
S
I
D
LF
GLNHM
---VF
I
K
D
VLVN
G
K
--
S
R
F
A
ELL
DG
V
A
--------------
-
---S
GQ
L
KA
SG
V
KNI
FDLPFSEGLIR
SL
N
L
LP
C
SYL
L
YY
F
K
Q
K
E
-
MLAI
E
MG
E
Y
YK
G
GARAQ
V
V
Q
KV
EKQLFE
L
YK
N
P
----------
E
L
KVKP
KELE
QRGG
A
YYS
D
A
------
AC
EV
INAI
Y
N
--------
D
K
Q
A
EH
YVN
----------------
I
P
H
HG
H
IDN
I
P
ADWA
VEM
T
C
T
L
G
R
D
G
AT
P
H
P
----
R
I
TH
F
DDKVM
GL
I
H
T
IKG
F
E
I
A
AS
NA
A
L
SGEFND
V
LL
A
LN
LSP
---
L
V
H
S
DRD
A
E
L
L
A
R
E
M
I
L
AH
EK
WLP
NF
ADCIAELKKAH
fig|656393.3.peg.2532
Escherichia coli H299
MSQK
L
KVV
T
IGGGS
S
Y
TP
EL
L
E
G
F
I
KRYHE
LP
VSE
L
W
L
V
D
V
E
GG
K
AKLDI
I
FDL
CQ
R
M
I
D
N
AG
VPM
K
LYK
T
L
D
R
REAL
K
DADFV
TTQL
RVG
Q
L
-
P
A
RELDERIPL
S
HG
Y
LGQ
---
ET
N
G
A
GG
L
FK
GLRTIP
V
I
F
D
IVKD
V
EE
L
CPNAW
VI
N
F
T
NPA
G
MVTEA
V
YR
HT
G
FK
R
F
IG
V
C
N
I
PIG
MKMF
I
R
DV
L
M
L
K
D
SDD
L
S
I
D
LF
GLNHM
---VF
I
K
D
VLVN
G
K
--
S
R
F
A
ELL
DG
V
A
--------------
-
---S
GQ
L
KA
SG
V
KNI
FDLPFSEGLIR
SM
N
L
LP
C
SYL
L
YY
F
K
Q
K
E
-
MLAI
E
MG
E
Y
YK
G
GARAQ
V
V
Q
KV
EKQLFE
L
YK
N
P
----------
E
L
KVKP
KELE
QRGG
A
YYS
D
A
------
AC
EV
INAI
Y
N
--------
D
K
Q
A
EH
YVN
----------------
I
P
H
HG
H
IDN
I
P
ADWA
VEM
T
C
T
L
G
R
D
G
AT
P
H
P
----
R
I
TH
F
DDKVM
GL
I
H
T
IKG
F
E
I
A
AS
NA
A
L
SGEFND
V
LL
A
LN
LSP
---
L
V
H
S
DRD
A
E
L
L
A
R
E
M
I
L
AH
EK
WLP
NF
ADCIAELKKAH
fig|670888.3.peg.236
Escherichia coli 1827-70
MSQK
L
KVV
T
IGGGS
S
Y
TP
EL
L
E
G
F
I
KRYHE
LP
VSE
L
W
L
V
D
V
E
GG
K
AKLDI
I
FDL
CQ
R
M
I
D
N
AG
VPM
K
LYK
T
L
D
R
REAL
K
DADFV
TTQL
RVG
Q
L
-
P
A
RELDERIPL
S
HG
Y
LGQ
---
ET
N
G
A
GG
L
FK
GLRTIP
V
I
F
D
IVKD
V
EE
L
CPNAW
VI
N
F
T
NPA
G
MVTEA
V
YR
HT
G
FK
R
F
IG
V
C
N
I
PIG
MKMF
I
R
DV
L
M
L
K
D
SDD
L
S
I
D
LF
GLNHM
---VF
I
K
D
VLVN
G
K
--
SL
F
A
ELL
DG
V
A
--------------
-
---S
GQ
L
KA
SG
V
KNI
FDLPFSEGLIR
SL
N
L
LP
C
SYL
L
YY
F
K
Q
K
E
-
MLAI
E
MG
E
Y
YK
G
GARAQ
V
V
Q
KV
EKQLFE
L
YK
N
P
----------
E
L
KVKP
KELE
QRGG
A
YYS
D
A
------
AC
EV
INAI
Y
N
--------
D
K
Q
A
EH
YVN
----------------
I
P
H
HG
H
IDN
I
P
ADWA
VEM
T
C
K
L
G
R
D
G
AT
P
H
P
----
R
I
TH
F
DDKVM
GL
I
H
T
IKG
F
E
I
A
AS
NA
A
L
SGEFND
V
LL
A
LN
LSP
---
L
V
H
S
DRD
A
E
L
L
A
R
E
M
I
L
AH
EK
WLP
NF
ADCIAELKKAH
fig|562.372.peg.4822
Escherichia coli 1212A
MSQK
L
KVV
T
IGGGS
S
Y
TP
EL
L
E
G
F
I
KRYHE
LP
VSE
L
W
L
V
D
V
E
GG
K
AKLDI
I
FDL
CQ
R
M
I
D
N
AG
VPM
K
LYK
T
L
D
R
REAL
K
DADFV
TTQL
RVG
Q
L
-
P
A
RELDERIPL
S
HG
Y
LGQ
---
ET
N
G
A
GG
L
FK
GLRTIP
V
I
F
D
IVKD
V
EE
L
CPNAW
VI
N
F
T
NPA
G
MVTEA
V
YR
HT
G
FK
R
F
IG
V
C
N
I
PIG
MKMF
I
R
DV
L
M
L
K
D
SDD
L
S
I
D
LF
GLNHM
---VF
I
K
D
VLVN
G
K
--
S
R
F
A
ELL
DG
V
A
--------------
-
---S
GQ
L
KA
SG
V
KNI
FDLPFSEGLIR
SL
N
L
LP
C
SYL
L
YY
F
K
Q
K
E
-
MLAI
E
MG
E
Y
YK
G
GARAQ
V
V
Q
KV
EKQLFE
L
YK
N
P
----------
E
L
KVKP
KELE
QRGG
A
YYS
D
A
------
AC
EM
INAI
Y
N
--------
D
K
Q
A
EH
YVN
----------------
I
P
H
HG
H
IDN
I
P
ADWA
VEM
T
C
T
L
G
R
D
G
AT
P
H
P
----
R
I
TH
F
DDKVM
GL
I
H
T
IKG
F
E
I
A
AS
NA
A
L
SGEFND
V
LL
A
LN
LSP
---
L
V
H
S
DRD
A
E
L
L
A
R
E
M
I
L
AH
EK
WLP
NF
ADCIAELKKAH
fig|562.374.peg.4290
Escherichia coli 536A
MSQK
L
KVV
T
IGGGS
S
Y
TP
EL
L
E
G
F
I
KRYHE
LP
VSE
L
W
L
V
D
V
E
GG
K
AKLDI
I
FDL
CQ
R
M
I
D
N
AG
VPM
K
LYK
T
L
D
R
REAL
K
DADFV
TTQL
RVG
Q
L
-
P
A
RELDERIPL
S
HG
Y
LGQ
---
ET
N
G
A
GG
L
FK
GLRTIP
V
I
F
D
IVKD
V
EE
L
CPNAW
VI
N
F
T
NPA
G
MVTEA
V
YR
HT
G
FK
R
F
IG
V
C
N
I
PIG
MKMF
I
R
DV
L
M
L
K
D
SDD
L
S
I
D
LF
GLNHM
---VF
I
K
D
VLVN
G
K
--
S
R
F
A
ELL
DG
V
A
--------------
-
---S
GQ
L
KA
SG
V
KNI
FDLPFSEGLIR
SL
N
L
LP
C
SYL
L
YY
F
K
Q
K
E
-
MLAI
E
MG
E
Y
YK
G
GARAQ
V
V
Q
KV
EKQLFE
L
YK
N
P
----------
E
L
KVKP
KELE
QRGG
A
YYS
D
A
------
AC
EM
INAI
Y
N
--------
D
K
Q
A
EH
YVN
----------------
I
P
H
HG
H
IDN
I
P
ADWA
VEM
T
C
T
L
G
R
D
G
AT
P
H
P
----
R
I
TH
F
DDKVM
GL
I
H
T
IKG
F
E
I
A
AS
NA
A
L
SGEFND
V
LL
A
LN
LSP
---
L
V
H
S
DRD
A
E
L
L
A
R
E
M
I
L
AH
EK
WLP
NF
ADCIAELKKAH
fig|656379.3.peg.2206
Escherichia coli FVEC1302
MSQK
L
KVV
T
IGGGS
S
Y
TP
EL
L
E
G
F
I
KRYHE
LP
VSE
L
W
L
V
D
V
E
GG
K
AKLDI
I
FDL
CQ
R
M
I
D
N
AG
VPM
K
LYK
T
L
D
R
REAL
K
DADFV
TTQL
RVG
Q
L
-
P
A
RELDERIPL
S
HG
Y
LGQ
---
ET
N
G
A
GG
L
FK
GLRTIP
V
I
F
N
IVKD
V
EE
L
CPNAW
VI
N
F
T
NPA
G
MVTEA
V
YR
HT
G
FK
R
F
IG
V
C
N
I
PIG
MKMF
I
R
DV
L
M
L
K
D
SDD
L
S
I
D
LF
GLNHM
---VF
I
K
D
VLVN
G
K
--
S
R
F
A
ELL
DG
V
A
--------------
-
---S
GQ
L
KA
SG
V
KNI
FDLPFSEGLIR
SL
N
L
LP
C
SYL
L
YY
F
K
Q
K
E
-
MLAI
E
MG
E
Y
YK
G
GARAQ
V
V
Q
KV
EKQLFE
L
YK
N
P
----------
E
L
KVKP
KELE
QRGG
A
YYS
D
A
------
AC
EV
INAI
Y
N
--------
D
K
Q
A
EH
YVN
----------------
I
P
H
HG
H
IDN
I
P
ADWA
VEM
T
C
T
L
G
R
D
G
AT
P
H
P
----
R
I
TH
F
DDKVM
GL
I
H
T
IKG
F
E
I
A
AS
NA
A
L
SGEFND
V
LL
A
LN
LSP
---
L
V
H
S
DRD
A
E
L
L
A
R
E
M
I
L
AH
EK
WLP
NF
ADCIAELKKAH
fig|656380.3.peg.3170
Escherichia coli FVEC1412
MSQK
L
KVV
T
IGGGS
S
Y
TP
EL
L
E
G
F
I
KRYHE
LP
VSE
L
W
L
V
D
V
E
GG
K
AKLDI
I
FDL
CQ
R
M
I
D
N
AG
VPM
K
LYK
T
L
D
R
REAL
K
DADFV
TTQL
RVG
Q
L
-
P
A
RELDERIPL
S
HG
Y
LGQ
---
ET
N
G
A
GG
L
FK
GLRTIP
V
I
F
N
IVKD
V
EE
L
CPNAW
VI
N
F
T
NPA
G
MVTEA
V
YR
HT
G
FK
R
F
IG
V
C
N
I
PIG
MKMF
I
R
DV
L
M
L
K
D
SDD
L
S
I
D
LF
GLNHM
---VF
I
K
D
VLVN
G
K
--
S
R
F
A
ELL
DG
V
A
--------------
-
---S
GQ
L
KA
SG
V
KNI
FDLPFSEGLIR
SL
N
L
LP
C
SYL
L
YY
F
K
Q
K
E
-
MLAI
E
MG
E
Y
YK
G
GARAQ
V
V
Q
KV
EKQLFE
L
YK
N
P
----------
E
L
KVKP
KELE
QRGG
A
YYS
D
A
------
AC
EV
INAI
Y
N
--------
D
K
Q
A
EH
YVN
----------------
I
P
H
HG
H
IDN
I
P
ADWA
VEM
T
C
T
L
G
R
D
G
AT
P
H
P
----
R
I
TH
F
DDKVM
GL
I
H
T
IKG
F
E
I
A
AS
NA
A
L
SGEFND
V
LL
A
LN
LSP
---
L
V
H
S
DRD
A
E
L
L
A
R
E
M
I
L
AH
EK
WLP
NF
ADCIAELKKAH
fig|749549.3.peg.2488
Escherichia coli MS 198-1
MSQK
L
KVV
T
IGGGS
S
Y
TP
EL
L
E
G
F
I
KRYHE
LP
VSE
L
W
L
V
D
V
E
GG
K
AKLDI
I
FDL
CQ
R
M
I
D
N
AG
VPM
K
LYK
T
L
D
R
REAL
K
DADFV
TTQL
RVG
Q
L
-
P
A
RELDERIPL
S
HG
Y
LGQ
---
ET
N
G
A
GG
L
FK
GLRTIP
V
I
F
N
IVKD
V
EE
L
CPNAW
VI
N
F
T
NPA
G
MVTEA
V
YR
HT
G
FK
R
F
IG
V
C
N
I
PIG
MKMF
I
R
DV
L
M
L
K
D
SDD
L
S
I
D
LF
GLNHM
---VF
I
K
D
VLVN
G
K
--
S
R
F
A
ELL
DG
V
A
--------------
-
---S
GQ
L
KA
SG
V
KNI
FDLPFSEGLIR
SL
N
L
LP
C
SYL
L
YY
F
K
Q
K
E
-
MLAI
E
MG
E
Y
YK
G
GARAQ
V
V
Q
KV
EKQLFE
L
YK
N
P
----------
E
L
KVKP
KELE
QRGG
A
YYS
D
A
------
AC
EV
INAI
Y
N
--------
D
K
Q
A
EH
YVN
----------------
I
P
H
HG
H
IDN
I
P
ADWA
VEM
T
C
T
L
G
R
D
G
AT
P
H
P
----
R
I
TH
F
DDKVM
GL
I
H
T
IKG
F
E
I
A
AS
NA
A
L
SGEFND
V
LL
A
LN
LSP
---
L
V
H
S
DRD
A
E
L
L
A
R
E
M
I
L
AH
EK
WLP
NF
ADCIAELKKAH
fig|585056.7.peg.2209
Escherichia coli UMN026
MSQK
L
KVV
T
IGGGS
S
Y
TP
EL
L
E
G
F
I
KRYHE
LP
VSE
L
W
L
V
D
V
E
GG
K
AKLDI
I
FDL
CQ
R
M
I
D
N
AG
VPM
K
LYK
T
L
D
R
REAL
K
DADFV
TTQL
RVG
Q
L
-
P
A
RELDERIPL
S
HG
Y
LGQ
---
ET
N
G
A
GG
L
FK
GLRTIP
V
I
F
N
IVKD
V
EE
L
CPNAW
VI
N
F
T
NPA
G
MVTEA
V
YR
HT
G
FK
R
F
IG
V
C
N
I
PIG
MKMF
I
R
DV
L
M
L
K
D
SDD
L
S
I
D
LF
GLNHM
---VF
I
K
D
VLVN
G
K
--
S
R
F
A
ELL
DG
V
A
--------------
-
---S
GQ
L
KA
SG
V
KNI
FDLPFSEGLIR
SL
N
L
LP
C
SYL
L
YY
F
K
Q
K
E
-
MLAI
E
MG
E
Y
YK
G
GARAQ
V
V
Q
KV
EKQLFE
L
YK
N
P
----------
E
L
KVKP
KELE
QRGG
A
YYS
D
A
------
AC
EV
INAI
Y
N
--------
D
K
Q
A
EH
YVN
----------------
I
P
H
HG
H
IDN
I
P
ADWA
VEM
T
C
T
L
G
R
D
G
AT
P
H
P
----
R
I
TH
F
DDKVM
GL
I
H
T
IKG
F
E
I
A
AS
NA
A
L
SGEFND
V
LL
A
LN
LSP
---
L
V
H
S
DRD
A
E
L
L
A
R
E
M
I
L
AH
EK
WLP
NF
ADCIAELKKAH
fig|405955.13.peg.1823
Escherichia coli APEC O1
MSQK
L
KVV
T
IGGGS
S
Y
TP
EL
L
E
G
F
I
KRYHE
LP
VSE
L
W
L
V
D
V
E
GG
K
AKLDI
I
FDL
CQ
R
M
I
D
N
AG
VPM
K
LYK
T
L
D
R
REAL
K
DADFV
TTQL
RVG
Q
L
-
P
A
RELDERIPL
S
HG
Y
LGQ
---
ET
N
G
A
GG
L
FK
GLRTIP
V
I
F
D
IVKD
V
EE
L
CPNAW
VI
N
F
T
NPA
G
MVTEA
V
YR
HT
G
FK
R
F
IG
V
C
N
I
PIG
MKMF
I
R
DV
L
M
L
K
D
SDD
L
S
I
D
LF
GLNHM
---VF
I
K
D
VLVN
G
K
--
S
R
F
A
ELL
DG
V
A
--------------
-
---S
GQ
L
KA
SG
V
KNI
FDLPFSEGLIR
SL
N
L
LP
C
SYL
L
YY
F
K
Q
K
E
-
MLAI
E
MG
E
Y
YK
G
GARAQ
V
V
Q
KV
EKQLFE
L
YK
N
P
----------
E
L
NVKP
KELE
QRGG
A
YYS
D
A
------
AC
EV
INAI
Y
N
--------
D
K
Q
A
EH
YVN
----------------
I
P
H
HG
H
IDN
I
P
ADWA
VEM
T
C
T
L
G
R
D
G
AT
P
H
P
----
R
I
TH
F
DDKVM
GL
I
H
T
IKG
F
E
I
A
AS
NA
A
L
SGEFND
V
LL
A
LN
LSP
---
L
V
H
S
DRD
A
E
L
L
A
R
E
M
I
L
AH
EK
WLP
NF
ADCIAELKKAH
fig|405955.9.peg.1488
Escherichia coli APEC O1 (24-473/473)
MSQK
L
KVV
T
IGGGS
S
Y
TP
EL
L
E
G
F
I
KRYHE
LP
VSE
L
W
L
V
D
V
E
GG
K
AKLDI
I
FDL
CQ
R
M
I
D
N
AG
VPM
K
LYK
T
L
D
R
REAL
K
DADFV
TTQL
RVG
Q
L
-
P
A
RELDERIPL
S
HG
Y
LGQ
---
ET
N
G
A
GG
L
FK
GLRTIP
V
I
F
D
IVKD
V
EE
L
CPNAW
VI
N
F
T
NPA
G
MVTEA
V
YR
HT
G
FK
R
F
IG
V
C
N
I
PIG
MKMF
I
R
DV
L
M
L
K
D
SDD
L
S
I
D
LF
GLNHM
---VF
I
K
D
VLVN
G
K
--
S
R
F
A
ELL
DG
V
A
--------------
-
---S
GQ
L
KA
SG
V
KNI
FDLPFSEGLIR
SL
N
L
LP
C
SYL
L
YY
F
K
Q
K
E
-
MLAI
E
MG
E
Y
YK
G
GARAQ
V
V
Q
KV
EKQLFE
L
YK
N
P
----------
E
L
NVKP
KELE
QRGG
A
YYS
D
A
------
AC
EV
INAI
Y
N
--------
D
K
Q
A
EH
YVN
----------------
I
P
H
HG
H
IDN
I
P
ADWA
VEM
T
C
T
L
G
R
D
G
AT
P
H
P
----
R
I
TH
F
DDKVM
GL
I
H
T
IKG
F
E
I
A
AS
NA
A
L
SGEFND
V
LL
A
LN
LSP
---
L
V
H
S
DRD
A
E
L
L
A
R
E
M
I
L
AH
EK
WLP
NF
ADCIAELKKAH
fig|585397.7.peg.1960
Escherichia coli ED1a
MSQK
L
KVV
T
IGGGS
S
Y
TP
EL
L
E
G
F
I
KRYHE
LP
VSE
L
W
L
V
D
V
E
GG
K
AKLDI
I
FDL
CQ
R
M
I
D
N
AG
VPM
K
LYK
T
L
D
R
REAL
K
DADFV
TTQL
RVG
Q
L
-
P
A
RELDERIPL
S
HG
Y
LGQ
---
ET
N
G
A
GG
L
FK
GLRTIP
V
I
F
D
IVKD
V
EE
L
CPNAW
VI
N
F
T
NPA
G
MVTEA
V
YR
HT
G
FK
R
F
IG
V
C
N
I
PIG
MKMF
I
R
DV
L
M
L
K
D
SDD
L
S
I
D
LF
GLNHM
---VF
I
K
D
VLVN
G
K
--
S
R
F
A
ELL
DG
V
A
--------------
-
---S
GQ
L
KA
SG
V
KNI
FDLPFSEGLIR
SL
N
L
LP
C
SYL
L
YY
F
K
Q
K
E
-
MLAI
E
MG
E
Y
YK
G
GARAQ
V
V
Q
KV
EKQLFE
L
YK
N
P
----------
E
L
NVKP
KELE
QRGG
A
YYS
D
A
------
AC
EV
INAI
Y
N
--------
D
K
Q
A
EH
YVN
----------------
I
P
H
HG
H
IDN
I
P
ADWA
VEM
T
C
T
L
G
R
D
G
AT
P
H
P
----
R
I
TH
F
DDKVM
GL
I
H
T
IKG
F
E
I
A
AS
NA
A
L
SGEFND
V
LL
A
LN
LSP
---
L
V
H
S
DRD
A
E
L
L
A
R
E
M
I
L
AH
EK
WLP
NF
ADCIAELKKAH
fig|585397.9.peg.1955
Escherichia coli ED1a
MSQK
L
KVV
T
IGGGS
S
Y
TP
EL
L
E
G
F
I
KRYHE
LP
VSE
L
W
L
V
D
V
E
GG
K
AKLDI
I
FDL
CQ
R
M
I
D
N
AG
VPM
K
LYK
T
L
D
R
REAL
K
DADFV
TTQL
RVG
Q
L
-
P
A
RELDERIPL
S
HG
Y
LGQ
---
ET
N
G
A
GG
L
FK
GLRTIP
V
I
F
D
IVKD
V
EE
L
CPNAW
VI
N
F
T
NPA
G
MVTEA
V
YR
HT
G
FK
R
F
IG
V
C
N
I
PIG
MKMF
I
R
DV
L
M
L
K
D
SDD
L
S
I
D
LF
GLNHM
---VF
I
K
D
VLVN
G
K
--
S
R
F
A
ELL
DG
V
A
--------------
-
---S
GQ
L
KA
SG
V
KNI
FDLPFSEGLIR
SL
N
L
LP
C
SYL
L
YY
F
K
Q
K
E
-
MLAI
E
MG
E
Y
YK
G
GARAQ
V
V
Q
KV
EKQLFE
L
YK
N
P
----------
E
L
NVKP
KELE
QRGG
A
YYS
D
A
------
AC
EV
INAI
Y
N
--------
D
K
Q
A
EH
YVN
----------------
I
P
H
HG
H
IDN
I
P
ADWA
VEM
T
C
T
L
G
R
D
G
AT
P
H
P
----
R
I
TH
F
DDKVM
GL
I
H
T
IKG
F
E
I
A
AS
NA
A
L
SGEFND
V
LL
A
LN
LSP
---
L
V
H
S
DRD
A
E
L
L
A
R
E
M
I
L
AH
EK
WLP
NF
ADCIAELKKAH
fig|714962.3.peg.1888
Escherichia coli IHE3034
MSQK
L
KVV
T
IGGGS
S
Y
TP
EL
L
E
G
F
I
KRYHE
LP
VSE
L
W
L
V
D
V
E
GG
K
AKLDI
I
FDL
CQ
R
M
I
D
N
AG
VPM
K
LYK
T
L
D
R
REAL
K
DADFV
TTQL
RVG
Q
L
-
P
A
RELDERIPL
S
HG
Y
LGQ
---
ET
N
G
A
GG
L
FK
GLRTIP
V
I
F
D
IVKD
V
EE
L
CPNAW
VI
N
F
T
NPA
G
MVTEA
V
YR
HT
G
FK
R
F
IG
V
C
N
I
PIG
MKMF
I
R
DV
L
M
L
K
D
SDD
L
S
I
D
LF
GLNHM
---VF
I
K
D
VLVN
G
K
--
S
R
F
A
ELL
DG
V
A
--------------
-
---S
GQ
L
KA
SG
V
KNI
FDLPFSEGLIR
SL
N
L
LP
C
SYL
L
YY
F
K
Q
K
E
-
MLAI
E
MG
E
Y
YK
G
GARAQ
V
V
Q
KV
EKQLFE
L
YK
N
P
----------
E
L
NVKP
KELE
QRGG
A
YYS
D
A
------
AC
EV
INAI
Y
N
--------
D
K
Q
A
EH
YVN
----------------
I
P
H
HG
H
IDN
I
P
ADWA
VEM
T
C
T
L
G
R
D
G
AT
P
H
P
----
R
I
TH
F
DDKVM
GL
I
H
T
IKG
F
E
I
A
AS
NA
A
L
SGEFND
V
LL
A
LN
LSP
---
L
V
H
S
DRD
A
E
L
L
A
R
E
M
I
L
AH
EK
WLP
NF
ADCIAELKKAH
fig|753642.3.peg.3228
Escherichia coli NC101
MSQK
L
KVV
T
IGGGS
S
Y
TP
EL
L
E
G
F
I
KRYHE
LP
VSE
L
W
L
V
D
V
E
GG
K
AKLDI
I
FDL
CQ
R
M
I
D
N
AG
VPM
K
LYK
T
L
D
R
REAL
K
DADFV
TTQL
RVG
Q
L
-
P
A
RELDERIPL
S
HG
Y
LGQ
---
ET
N
G
A
GG
L
FK
GLRTIP
V
I
F
D
IVKD
V
EE
L
CPNAW
VI
N
F
T
NPA
G
MVTEA
V
YR
HT
G
FK
R
F
IG
V
C
N
I
PIG
MKMF
I
R
DV
L
M
L
K
D
SDD
L
S
I
D
LF
GLNHM
---VF
I
K
D
VLVN
G
K
--
S
R
F
A
ELL
DG
V
A
--------------
-
---S
GQ
L
KA
SG
V
KNI
FDLPFSEGLIR
SL
N
L
LP
C
SYL
L
YY
F
K
Q
K
E
-
MLAI
E
MG
E
Y
YK
G
GARAQ
V
V
Q
KV
EKQLFE
L
YK
N
P
----------
E
L
NVKP
KELE
QRGG
A
YYS
D
A
------
AC
EV
INAI
Y
N
--------
D
K
Q
A
EH
YVN
----------------
I
P
H
HG
H
IDN
I
P
ADWA
VEM
T
C
T
L
G
R
D
G
AT
P
H
P
----
R
I
TH
F
DDKVM
GL
I
H
T
IKG
F
E
I
A
AS
NA
A
L
SGEFND
V
LL
A
LN
LSP
---
L
V
H
S
DRD
A
E
L
L
A
R
E
M
I
L
AH
EK
WLP
NF
ADCIAELKKAH
fig|585035.6.peg.1775
Escherichia coli S88
MSQK
L
KVV
T
IGGGS
S
Y
TP
EL
L
E
G
F
I
KRYHE
LP
VSE
L
W
L
V
D
V
E
GG
K
AKLDI
I
FDL
CQ
R
M
I
D
N
AG
VPM
K
LYK
T
L
D
R
REAL
K
DADFV
TTQL
RVG
Q
L
-
P
A
RELDERIPL
S
HG
Y
LGQ
---
ET
N
G
A
GG
L
FK
GLRTIP
V
I
F
D
IVKD
V
EE
L
CPNAW
VI
N
F
T
NPA
G
MVTEA
V
YR
HT
G
FK
R
F
IG
V
C
N
I
PIG
MKMF
I
R
DV
L
M
L
K
D
SDD
L
S
I
D
LF
GLNHM
---VF
I
K
D
VLVN
G
K
--
S
R
F
A
ELL
DG
V
A
--------------
-
---S
GQ
L
KA
SG
V
KNI
FDLPFSEGLIR
SL
N
L
LP
C
SYL
L
YY
F
K
Q
K
E
-
MLAI
E
MG
E
Y
YK
G
GARAQ
V
V
Q
KV
EKQLFE
L
YK
N
P
----------
E
L
NVKP
KELE
QRGG
A
YYS
D
A
------
AC
EV
INAI
Y
N
--------
D
K
Q
A
EH
YVN
----------------
I
P
H
HG
H
IDN
I
P
ADWA
VEM
T
C
T
L
G
R
D
G
AT
P
H
P
----
R
I
TH
F
DDKVM
GL
I
H
T
IKG
F
E
I
A
AS
NA
A
L
SGEFND
V
LL
A
LN
LSP
---
L
V
H
S
DRD
A
E
L
L
A
R
E
M
I
L
AH
EK
WLP
NF
ADCIAELKKAH
fig|656440.3.peg.1652
Escherichia coli TA206
MSQK
L
KVV
T
IGGGS
S
Y
TP
EL
L
E
G
F
I
KRYHE
LP
VSE
L
W
L
V
D
V
E
GG
K
AKLDI
I
FDL
CQ
R
M
I
D
N
AG
VPM
K
LYK
T
L
D
R
REAL
K
DADFV
TTQL
RVG
Q
L
-
P
A
RELDERIPL
S
HG
Y
LGQ
---
ET
N
G
A
GG
L
FK
GLRTIP
V
I
F
D
IVKD
V
EE
L
CPNAW
VI
N
F
T
NPA
G
MVTEA
V
YR
HT
G
FK
R
F
IG
V
C
N
I
PIG
MKMF
I
R
DV
L
M
L
K
D
SDD
L
S
I
D
LF
GLNHM
---VF
I
K
D
VLVN
G
K
--
S
R
F
A
ELL
DG
V
A
--------------
-
---S
GQ
L
KA
SG
V
KNI
FDLPFSEGLIR
SL
N
L
LP
C
SYL
L
YY
F
K
Q
K
E
-
MLAI
E
MG
E
Y
YK
G
GARAQ
V
V
Q
KV
EKQLFE
L
YK
N
P
----------
E
L
NVKP
KELE
QRGG
A
YYS
D
A
------
AC
EV
INAI
Y
N
--------
D
K
Q
A
EH
YVN
----------------
I
P
H
HG
H
IDN
I
P
ADWA
VEM
T
C
T
L
G
R
D
G
AT
P
H
P
----
R
I
TH
F
DDKVM
GL
I
H
T
IKG
F
E
I
A
AS
NA
A
L
SGEFND
V
LL
A
LN
LSP
---
L
V
H
S
DRD
A
E
L
L
A
R
E
M
I
L
AH
EK
WLP
NF
ADCIAELKKAH
fig|869729.3.peg.1800
Escherichia coli UM146
MSQK
L
KVV
T
IGGGS
S
Y
TP
EL
L
E
G
F
I
KRYHE
LP
VSE
L
W
L
V
D
V
E
GG
K
AKLDI
I
FDL
CQ
R
M
I
D
N
AG
VPM
K
LYK
T
L
D
R
REAL
K
DADFV
TTQL
RVG
Q
L
-
P
A
RELDERIPL
S
HG
Y
LGQ
---
ET
N
G
A
GG
L
FK
GLRTIP
V
I
F
D
IVKD
V
EE
L
CPNAW
VI
N
F
T
NPA
G
MVTEA
V
YR
HT
G
FK
R
F
IG
V
C
N
I
PIG
MKMF
I
R
DV
L
M
L
K
D
SDD
L
S
I
D
LF
GLNHM
---VF
I
K
D
VLVN
G
K
--
S
R
F
A
ELL
DG
V
A
--------------
-
---S
GQ
L
KA
SG
V
KNI
FDLPFSEGLIR
SL
N
L
LP
C
SYL
L
YY
F
K
Q
K
E
-
MLAI
E
MG
E
Y
YK
G
GARAQ
V
V
Q
KV
EKQLFE
L
YK
N
P
----------
E
L
NVKP
KELE
QRGG
A
YYS
D
A
------
AC
EV
INAI
Y
N
--------
D
K
Q
A
EH
YVN
----------------
I
P
H
HG
H
IDN
I
P
ADWA
VEM
T
C
T
L
G
R
D
G
AT
P
H
P
----
R
I
TH
F
DDKVM
GL
I
H
T
IKG
F
E
I
A
AS
NA
A
L
SGEFND
V
LL
A
LN
LSP
---
L
V
H
S
DRD
A
E
L
L
A
R
E
M
I
L
AH
EK
WLP
NF
ADCIAELKKAH
fig|364106.7.peg.1967
Escherichia coli UTI89
MSQK
L
KVV
T
IGGGS
S
Y
TP
EL
L
E
G
F
I
KRYHE
LP
VSE
L
W
L
V
D
V
E
GG
K
AKLDI
I
FDL
CQ
R
M
I
D
N
AG
VPM
K
LYK
T
L
D
R
REAL
K
DADFV
TTQL
RVG
Q
L
-
P
A
RELDERIPL
S
HG
Y
LGQ
---
ET
N
G
A
GG
L
FK
GLRTIP
V
I
F
D
IVKD
V
EE
L
CPNAW
VI
N
F
T
NPA
G
MVTEA
V
YR
HT
G
FK
R
F
IG
V
C
N
I
PIG
MKMF
I
R
DV
L
M
L
K
D
SDD
L
S
I
D
LF
GLNHM
---VF
I
K
D
VLVN
G
K
--
S
R
F
A
ELL
DG
V
A
--------------
-
---S
GQ
L
KA
SG
V
KNI
FDLPFSEGLIR
SL
N
L
LP
C
SYL
L
YY
F
K
Q
K
E
-
MLAI
E
MG
E
Y
YK
G
GARAQ
V
V
Q
KV
EKQLFE
L
YK
N
P
----------
E
L
NVKP
KELE
QRGG
A
YYS
D
A
------
AC
EV
INAI
Y
N
--------
D
K
Q
A
EH
YVN
----------------
I
P
H
HG
H
IDN
I
P
ADWA
VEM
T
C
T
L
G
R
D
G
AT
P
H
P
----
R
I
TH
F
DDKVM
GL
I
H
T
IKG
F
E
I
A
AS
NA
A
L
SGEFND
V
LL
A
LN
LSP
---
L
V
H
S
DRD
A
E
L
L
A
R
E
M
I
L
AH
EK
WLP
NF
ADCIAELKKAH
fig|364106.8.peg.1970
Escherichia coli UTI89
MSQK
L
KVV
T
IGGGS
S
Y
TP
EL
L
E
G
F
I
KRYHE
LP
VSE
L
W
L
V
D
V
E
GG
K
AKLDI
I
FDL
CQ
R
M
I
D
N
AG
VPM
K
LYK
T
L
D
R
REAL
K
DADFV
TTQL
RVG
Q
L
-
P
A
RELDERIPL
S
HG
Y
LGQ
---
ET
N
G
A
GG
L
FK
GLRTIP
V
I
F
D
IVKD
V
EE
L
CPNAW
VI
N
F
T
NPA
G
MVTEA
V
YR
HT
G
FK
R
F
IG
V
C
N
I
PIG
MKMF
I
R
DV
L
M
L
K
D
SDD
L
S
I
D
LF
GLNHM
---VF
I
K
D
VLVN
G
K
--
S
R
F
A
ELL
DG
V
A
--------------
-
---S
GQ
L
KA
SG
V
KNI
FDLPFSEGLIR
SL
N
L
LP
C
SYL
L
YY
F
K
Q
K
E
-
MLAI
E
MG
E
Y
YK
G
GARAQ
V
V
Q
KV
EKQLFE
L
YK
N
P
----------
E
L
NVKP
KELE
QRGG
A
YYS
D
A
------
AC
EV
INAI
Y
N
--------
D
K
Q
A
EH
YVN
----------------
I
P
H
HG
H
IDN
I
P
ADWA
VEM
T
C
T
L
G
R
D
G
AT
P
H
P
----
R
I
TH
F
DDKVM
GL
I
H
T
IKG
F
E
I
A
AS
NA
A
L
SGEFND
V
LL
A
LN
LSP
---
L
V
H
S
DRD
A
E
L
L
A
R
E
M
I
L
AH
EK
WLP
NF
ADCIAELKKAH
fig|685038.3.peg.1750
Escherichia coli O83:H1 str. NRG 857C
MSQK
L
KVV
T
IGGGS
S
Y
TP
EL
L
E
G
F
I
KRYHE
LP
VSE
L
W
L
V
D
V
E
GG
K
AKLDI
I
FDL
CQ
R
M
I
D
N
AG
VPM
K
LYK
T
L
D
R
REAL
K
DADFV
TTQL
RVG
Q
L
-
P
A
RELDERIPL
S
HG
Y
LGQ
---
ET
N
G
A
GG
L
FK
GLRTIP
V
I
F
D
IVKD
V
EE
L
CPNAW
VI
N
F
T
NPA
G
MVTEA
V
YR
HT
G
FK
R
F
IG
V
C
N
I
PIG
MKMF
I
R
DV
L
M
L
K
D
CDD
L
S
I
D
LF
GLNHM
---VF
I
K
D
VLVN
G
K
--
S
R
F
A
ELL
DG
V
A
--------------
-
---S
GQ
L
KA
SG
V
KNI
FDLPFSEGLIR
SL
N
L
LP
C
SYL
L
YY
F
K
Q
K
E
-
MLAI
E
MG
E
Y
YK
G
GARAQ
V
V
Q
KV
EKQLFE
L
YK
N
P
----------
E
L
KVKP
KELE
QRGG
A
YYS
D
A
------
AC
EV
INAI
Y
N
--------
D
K
Q
A
EH
YVN
----------------
I
P
H
HG
H
IDN
I
P
ADWA
VEM
T
C
T
L
G
R
D
G
AT
P
H
P
----
R
I
TH
F
DDKVM
GL
I
H
T
IKG
F
E
I
A
AS
NA
A
L
SGEFND
V
LL
A
LN
LSP
---
L
V
H
S
DRD
A
E
L
L
A
R
E
M
I
L
AH
EK
WLP
NF
ADCIAELKKAH
fig|670897.3.peg.2616
Escherichia coli 2362-75
MSQK
L
KVV
T
IGGGS
S
Y
TP
EL
L
E
G
F
I
KRYHE
LP
VSE
L
W
L
V
D
V
E
GG
K
AKLDI
I
FDL
CQ
R
M
I
D
N
AG
VPM
K
LYK
T
L
D
R
REAL
K
DADFV
TTQL
RVG
Q
L
-
P
A
RELDERIPL
S
HG
Y
LGQ
---
ET
N
G
A
GG
L
FK
GLRTIP
V
I
F
D
IVKD
V
EE
L
CPNAW
VI
N
F
T
NPA
G
MVTEA
V
YR
HT
G
FK
R
F
IG
V
C
N
I
PIG
MKMF
I
R
DV
L
M
L
K
D
SDD
L
S
I
D
LF
GLNHM
---VF
I
K
D
VLVN
G
K
--
S
R
F
A
ELL
DG
V
A
--------------
-
---S
GQ
L
KA
SG
V
KNI
FDLPFSEGLIR
SM
N
L
LP
C
SYL
L
YY
F
K
Q
K
E
-
MLAI
E
MG
E
Y
YK
G
GARAQ
V
V
Q
KV
EKQLFE
L
YK
N
P
----------
E
L
NVKP
KELE
QRGG
A
YYS
D
A
------
AC
EV
INAI
Y
N
--------
D
K
Q
A
EH
YVN
----------------
I
P
H
HG
H
IDN
I
P
ADWA
VEM
T
C
T
L
G
R
D
G
AT
P
H
P
----
R
I
TH
F
DDKVM
GL
I
H
T
IKG
F
E
I
A
AS
NA
A
L
SGEFND
V
LL
A
LN
LSP
---
L
V
H
S
DRD
A
E
L
L
A
R
E
M
I
L
AH
EK
WLP
NF
ADCIAELKKAH
fig|362663.8.peg.1697
Escherichia coli 536
MSQK
L
KVV
T
IGGGS
S
Y
TP
EL
L
E
G
F
I
KRYHE
LP
VSE
L
W
L
V
D
V
E
GG
K
AKLDI
I
FDL
CQ
R
M
I
D
N
AG
VPM
K
LYK
T
L
D
R
REAL
K
DADFV
TTQL
RVG
Q
L
-
P
A
RELDERIPL
S
HG
Y
LGQ
---
ET
N
G
A
GG
L
FK
GLRTIP
V
I
F
D
IVKD
V
EE
L
CPNAW
VI
N
F
T
NPA
G
MVTEA
V
YR
HT
G
FK
R
F
IG
V
C
N
I
PIG
MKMF
I
R
DV
L
M
L
K
D
SDD
L
S
I
D
LF
GLNHM
---VF
I
K
D
VLVN
G
K
--
S
R
F
A
ELL
DG
V
A
--------------
-
---S
GQ
L
KA
SG
V
KNI
FDLPFSEGLIR
SM
N
L
LP
C
SYL
L
YY
F
K
Q
K
E
-
MLAI
E
MG
E
Y
YK
G
GARAQ
V
V
Q
KV
EKQLFE
L
YK
N
P
----------
E
L
NVKP
KELE
QRGG
A
YYS
D
A
------
AC
EV
INAI
Y
N
--------
D
K
Q
A
EH
YVN
----------------
I
P
H
HG
H
IDN
I
P
ADWA
VEM
T
C
T
L
G
R
D
G
AT
P
H
P
----
R
I
TH
F
DDKVM
GL
I
H
T
IKG
F
E
I
A
AS
NA
A
L
SGEFND
V
LL
A
LN
LSP
---
L
V
H
S
DRD
A
E
L
L
A
R
E
M
I
L
AH
EK
WLP
NF
ADCIAELKKAH
fig|362663.9.peg.1701
Escherichia coli 536
MSQK
L
KVV
T
IGGGS
S
Y
TP
EL
L
E
G
F
I
KRYHE
LP
VSE
L
W
L
V
D
V
E
GG
K
AKLDI
I
FDL
CQ
R
M
I
D
N
AG
VPM
K
LYK
T
L
D
R
REAL
K
DADFV
TTQL
RVG
Q
L
-
P
A
RELDERIPL
S
HG
Y
LGQ
---
ET
N
G
A
GG
L
FK
GLRTIP
V
I
F
D
IVKD
V
EE
L
CPNAW
VI
N
F
T
NPA
G
MVTEA
V
YR
HT
G
FK
R
F
IG
V
C
N
I
PIG
MKMF
I
R
DV
L
M
L
K
D
SDD
L
S
I
D
LF
GLNHM
---VF
I
K
D
VLVN
G
K
--
S
R
F
A
ELL
DG
V
A
--------------
-
---S
GQ
L
KA
SG
V
KNI
FDLPFSEGLIR
SM
N
L
LP
C
SYL
L
YY
F
K
Q
K
E
-
MLAI
E
MG
E
Y
YK
G
GARAQ
V
V
Q
KV
EKQLFE
L
YK
N
P
----------
E
L
NVKP
KELE
QRGG
A
YYS
D
A
------
AC
EV
INAI
Y
N
--------
D
K
Q
A
EH
YVN
----------------
I
P
H
HG
H
IDN
I
P
ADWA
VEM
T
C
T
L
G
R
D
G
AT
P
H
P
----
R
I
TH
F
DDKVM
GL
I
H
T
IKG
F
E
I
A
AS
NA
A
L
SGEFND
V
LL
A
LN
LSP
---
L
V
H
S
DRD
A
E
L
L
A
R
E
M
I
L
AH
EK
WLP
NF
ADCIAELKKAH
fig|525281.3.peg.768
Escherichia coli 83972
MSQK
L
KVV
T
IGGGS
S
Y
TP
EL
L
E
G
F
I
KRYHE
LP
VSE
L
W
L
V
D
V
E
GG
K
AKLDI
I
FDL
CQ
R
M
I
D
N
AG
VPM
K
LYK
T
L
D
R
REAL
K
DADFV
TTQL
RVG
Q
L
-
P
A
RELDERIPL
S
HG
Y
LGQ
---
ET
N
G
A
GG
L
FK
GLRTIP
V
I
F
D
IVKD
V
EE
L
CPNAW
VI
N
F
T
NPA
G
MVTEA
V
YR
HT
G
FK
R
F
IG
V
C
N
I
PIG
MKMF
I
R
DV
L
M
L
K
D
SDD
L
S
I
D
LF
GLNHM
---VF
I
K
D
VLVN
G
K
--
S
R
F
A
ELL
DG
V
A
--------------
-
---S
GQ
L
KA
SG
V
KNI
FDLPFSEGLIR
SM
N
L
LP
C
SYL
L
YY
F
K
Q
K
E
-
MLAI
E
MG
E
Y
YK
G
GARAQ
V
V
Q
KV
EKQLFE
L
YK
N
P
----------
E
L
NVKP
KELE
QRGG
A
YYS
D
A
------
AC
EV
INAI
Y
N
--------
D
K
Q
A
EH
YVN
----------------
I
P
H
HG
H
IDN
I
P
ADWA
VEM
T
C
T
L
G
R
D
G
AT
P
H
P
----
R
I
TH
F
DDKVM
GL
I
H
T
IKG
F
E
I
A
AS
NA
A
L
SGEFND
V
LL
A
LN
LSP
---
L
V
H
S
DRD
A
E
L
L
A
R
E
M
I
L
AH
EK
WLP
NF
ADCIAELKKAH
fig|655817.3.peg.2083
Escherichia coli ABU 83972
MSQK
L
KVV
T
IGGGS
S
Y
TP
EL
L
E
G
F
I
KRYHE
LP
VSE
L
W
L
V
D
V
E
GG
K
AKLDI
I
FDL
CQ
R
M
I
D
N
AG
VPM
K
LYK
T
L
D
R
REAL
K
DADFV
TTQL
RVG
Q
L
-
P
A
RELDERIPL
S
HG
Y
LGQ
---
ET
N
G
A
GG
L
FK
GLRTIP
V
I
F
D
IVKD
V
EE
L
CPNAW
VI
N
F
T
NPA
G
MVTEA
V
YR
HT
G
FK
R
F
IG
V
C
N
I
PIG
MKMF
I
R
DV
L
M
L
K
D
SDD
L
S
I
D
LF
GLNHM
---VF
I
K
D
VLVN
G
K
--
S
R
F
A
ELL
DG
V
A
--------------
-
---S
GQ
L
KA
SG
V
KNI
FDLPFSEGLIR
SM
N
L
LP
C
SYL
L
YY
F
K
Q
K
E
-
MLAI
E
MG
E
Y
YK
G
GARAQ
V
V
Q
KV
EKQLFE
L
YK
N
P
----------
E
L
NVKP
KELE
QRGG
A
YYS
D
A
------
AC
EV
INAI
Y
N
--------
D
K
Q
A
EH
YVN
----------------
I
P
H
HG
H
IDN
I
P
ADWA
VEM
T
C
T
L
G
R
D
G
AT
P
H
P
----
R
I
TH
F
DDKVM
GL
I
H
T
IKG
F
E
I
A
AS
NA
A
L
SGEFND
V
LL
A
LN
LSP
---
L
V
H
S
DRD
A
E
L
L
A
R
E
M
I
L
AH
EK
WLP
NF
ADCIAELKKAH
fig|199310.1.peg.2070
Escherichia coli CFT073 (19-468/468)
MSQK
L
KVV
T
IGGGS
S
Y
TP
EL
L
E
G
F
I
KRYHE
LP
VSE
L
W
L
V
D
V
E
GG
K
AKLDI
I
FDL
CQ
R
M
I
D
N
AG
VPM
K
LYK
T
L
D
R
REAL
K
DADFV
TTQL
RVG
Q
L
-
P
A
RELDERIPL
S
HG
Y
LGQ
---
ET
N
G
A
GG
L
FK
GLRTIP
V
I
F
D
IVKD
V
EE
L
CPNAW
VI
N
F
T
NPA
G
MVTEA
V
YR
HT
G
FK
R
F
IG
V
C
N
I
PIG
MKMF
I
R
DV
L
M
L
K
D
SDD
L
S
I
D
LF
GLNHM
---VF
I
K
D
VLVN
G
K
--
S
R
F
A
ELL
DG
V
A
--------------
-
---S
GQ
L
KA
SG
V
KNI
FDLPFSEGLIR
SM
N
L
LP
C
SYL
L
YY
F
K
Q
K
E
-
MLAI
E
MG
E
Y
YK
G
GARAQ
V
V
Q
KV
EKQLFE
L
YK
N
P
----------
E
L
NVKP
KELE
QRGG
A
YYS
D
A
------
AC
EV
INAI
Y
N
--------
D
K
Q
A
EH
YVN
----------------
I
P
H
HG
H
IDN
I
P
ADWA
VEM
T
C
T
L
G
R
D
G
AT
P
H
P
----
R
I
TH
F
DDKVM
GL
I
H
T
IKG
F
E
I
A
AS
NA
A
L
SGEFND
V
LL
A
LN
LSP
---
L
V
H
S
DRD
A
E
L
L
A
R
E
M
I
L
AH
EK
WLP
NF
ADCIAELKKAH
fig|199310.4.peg.1998
Escherichia coli CFT073
MSQK
L
KVV
T
IGGGS
S
Y
TP
EL
L
E
G
F
I
KRYHE
LP
VSE
L
W
L
V
D
V
E
GG
K
AKLDI
I
FDL
CQ
R
M
I
D
N
AG
VPM
K
LYK
T
L
D
R
REAL
K
DADFV
TTQL
RVG
Q
L
-
P
A
RELDERIPL
S
HG
Y
LGQ
---
ET
N
G
A
GG
L
FK
GLRTIP
V
I
F
D
IVKD
V
EE
L
CPNAW
VI
N
F
T
NPA
G
MVTEA
V
YR
HT
G
FK
R
F
IG
V
C
N
I
PIG
MKMF
I
R
DV
L
M
L
K
D
SDD
L
S
I
D
LF
GLNHM
---VF
I
K
D
VLVN
G
K
--
S
R
F
A
ELL
DG
V
A
--------------
-
---S
GQ
L
KA
SG
V
KNI
FDLPFSEGLIR
SM
N
L
LP
C
SYL
L
YY
F
K
Q
K
E
-
MLAI
E
MG
E
Y
YK
G
GARAQ
V
V
Q
KV
EKQLFE
L
YK
N
P
----------
E
L
NVKP
KELE
QRGG
A
YYS
D
A
------
AC
EV
INAI
Y
N
--------
D
K
Q
A
EH
YVN
----------------
I
P
H
HG
H
IDN
I
P
ADWA
VEM
T
C
T
L
G
R
D
G
AT
P
H
P
----
R
I
TH
F
DDKVM
GL
I
H
T
IKG
F
E
I
A
AS
NA
A
L
SGEFND
V
LL
A
LN
LSP
---
L
V
H
S
DRD
A
E
L
L
A
R
E
M
I
L
AH
EK
WLP
NF
ADCIAELKKAH
fig|216593.1.peg.557
Escherichia coli E2348/69 (24-473/473)
MSQK
L
KVV
T
IGGGS
S
Y
TP
EL
L
E
G
F
I
KRYHE
LP
VSE
L
W
L
V
D
V
E
GG
K
AKLDI
I
FDL
CQ
R
M
I
D
N
AG
VPM
K
LYK
T
L
D
R
REAL
K
DADFV
TTQL
RVG
Q
L
-
P
A
RELDERIPL
S
HG
Y
LGQ
---
ET
N
G
A
GG
L
FK
GLRTIP
V
I
F
D
IVKD
V
EE
L
CPNAW
VI
N
F
T
NPA
G
MVTEA
V
YR
HT
G
FK
R
F
IG
V
C
N
I
PIG
MKMF
I
R
DV
L
M
L
K
D
SDD
L
S
I
D
LF
GLNHM
---VF
I
K
D
VLVN
G
K
--
S
R
F
A
ELL
DG
V
A
--------------
-
---S
GQ
L
KA
SG
V
KNI
FDLPFSEGLIR
SM
N
L
LP
C
SYL
L
YY
F
K
Q
K
E
-
MLAI
E
MG
E
Y
YK
G
GARAQ
V
V
Q
KV
EKQLFE
L
YK
N
P
----------
E
L
NVKP
KELE
QRGG
A
YYS
D
A
------
AC
EV
INAI
Y
N
--------
D
K
Q
A
EH
YVN
----------------
I
P
H
HG
H
IDN
I
P
ADWA
VEM
T
C
T
L
G
R
D
G
AT
P
H
P
----
R
I
TH
F
DDKVM
GL
I
H
T
IKG
F
E
I
A
AS
NA
A
L
SGEFND
V
LL
A
LN
LSP
---
L
V
H
S
DRD
A
E
L
L
A
R
E
M
I
L
AH
EK
WLP
NF
ADCIAELKKAH
fig|340197.3.peg.1810
Escherichia coli F11
MSQK
L
KVV
T
IGGGS
S
Y
TP
EL
L
E
G
F
I
KRYHE
LP
VSE
L
W
L
V
D
V
E
GG
K
AKLDI
I
FDL
CQ
R
M
I
D
N
AG
VPM
K
LYK
T
L
D
R
REAL
K
DADFV
TTQL
RVG
Q
L
-
P
A
RELDERIPL
S
HG
Y
LGQ
---
ET
N
G
A
GG
L
FK
GLRTIP
V
I
F
D
IVKD
V
EE
L
CPNAW
VI
N
F
T
NPA
G
MVTEA
V
YR
HT
G
FK
R
F
IG
V
C
N
I
PIG
MKMF
I
R
DV
L
M
L
K
D
SDD
L
S
I
D
LF
GLNHM
---VF
I
K
D
VLVN
G
K
--
S
R
F
A
ELL
DG
V
A
--------------
-
---S
GQ
L
KA
SG
V
KNI
FDLPFSEGLIR
SM
N
L
LP
C
SYL
L
YY
F
K
Q
K
E
-
MLAI
E
MG
E
Y
YK
G
GARAQ
V
V
Q
KV
EKQLFE
L
YK
N
P
----------
E
L
NVKP
KELE
QRGG
A
YYS
D
A
------
AC
EV
INAI
Y
N
--------
D
K
Q
A
EH
YVN
----------------
I
P
H
HG
H
IDN
I
P
ADWA
VEM
T
C
T
L
G
R
D
G
AT
P
H
P
----
R
I
TH
F
DDKVM
GL
I
H
T
IKG
F
E
I
A
AS
NA
A
L
SGEFND
V
LL
A
LN
LSP
---
L
V
H
S
DRD
A
E
L
L
A
R
E
M
I
L
AH
EK
WLP
NF
ADCIAELKKAH
fig|340197.5.peg.1907
Escherichia coli F11
MSQK
L
KVV
T
IGGGS
S
Y
TP
EL
L
E
G
F
I
KRYHE
LP
VSE
L
W
L
V
D
V
E
GG
K
AKLDI
I
FDL
CQ
R
M
I
D
N
AG
VPM
K
LYK
T
L
D
R
REAL
K
DADFV
TTQL
RVG
Q
L
-
P
A
RELDERIPL
S
HG
Y
LGQ
---
ET
N
G
A
GG
L
FK
GLRTIP
V
I
F
D
IVKD
V
EE
L
CPNAW
VI
N
F
T
NPA
G
MVTEA
V
YR
HT
G
FK
R
F
IG
V
C
N
I
PIG
MKMF
I
R
DV
L
M
L
K
D
SDD
L
S
I
D
LF
GLNHM
---VF
I
K
D
VLVN
G
K
--
S
R
F
A
ELL
DG
V
A
--------------
-
---S
GQ
L
KA
SG
V
KNI
FDLPFSEGLIR
SM
N
L
LP
C
SYL
L
YY
F
K
Q
K
E
-
MLAI
E
MG
E
Y
YK
G
GARAQ
V
V
Q
KV
EKQLFE
L
YK
N
P
----------
E
L
NVKP
KELE
QRGG
A
YYS
D
A
------
AC
EV
INAI
Y
N
--------
D
K
Q
A
EH
YVN
----------------
I
P
H
HG
H
IDN
I
P
ADWA
VEM
T
C
T
L
G
R
D
G
AT
P
H
P
----
R
I
TH
F
DDKVM
GL
I
H
T
IKG
F
E
I
A
AS
NA
A
L
SGEFND
V
LL
A
LN
LSP
---
L
V
H
S
DRD
A
E
L
L
A
R
E
M
I
L
AH
EK
WLP
NF
ADCIAELKKAH
fig|749546.3.peg.4476
Escherichia coli MS 185-1
MSQK
L
KVV
T
IGGGS
S
Y
TP
EL
L
E
G
F
I
KRYHE
LP
VSE
L
W
L
V
D
V
E
GG
K
AKLDI
I
FDL
CQ
R
M
I
D
N
AG
VPM
K
LYK
T
L
D
R
REAL
K
DADFV
TTQL
RVG
Q
L
-
P
A
RELDERIPL
S
HG
Y
LGQ
---
ET
N
G
A
GG
L
FK
GLRTIP
V
I
F
D
IVKD
V
EE
L
CPNAW
VI
N
F
T
NPA
G
MVTEA
V
YR
HT
G
FK
R
F
IG
V
C
N
I
PIG
MKMF
I
R
DV
L
M
L
K
D
SDD
L
S
I
D
LF
GLNHM
---VF
I
K
D
VLVN
G
K
--
S
R
F
A
ELL
DG
V
A
--------------
-
---S
GQ
L
KA
SG
V
KNI
FDLPFSEGLIR
SM
N
L
LP
C
SYL
L
YY
F
K
Q
K
E
-
MLAI
E
MG
E
Y
YK
G
GARAQ
V
V
Q
KV
EKQLFE
L
YK
N
P
----------
E
L
NVKP
KELE
QRGG
A
YYS
D
A
------
AC
EV
INAI
Y
N
--------
D
K
Q
A
EH
YVN
----------------
I
P
H
HG
H
IDN
I
P
ADWA
VEM
T
C
T
L
G
R
D
G
AT
P
H
P
----
R
I
TH
F
DDKVM
GL
I
H
T
IKG
F
E
I
A
AS
NA
A
L
SGEFND
V
LL
A
LN
LSP
---
L
V
H
S
DRD
A
E
L
L
A
R
E
M
I
L
AH
EK
WLP
NF
ADCIAELKKAH
fig|749550.3.peg.3132
Escherichia coli MS 200-1
MSQK
L
KVV
T
IGGGS
S
Y
TP
EL
L
E
G
F
I
KRYHE
LP
VSE
L
W
L
V
D
V
E
GG
K
AKLDI
I
FDL
CQ
R
M
I
D
N
AG
VPM
K
LYK
T
L
D
R
REAL
K
DADFV
TTQL
RVG
Q
L
-
P
A
RELDERIPL
S
HG
Y
LGQ
---
ET
N
G
A
GG
L
FK
GLRTIP
V
I
F
D
IVKD
V
EE
L
CPNAW
VI
N
F
T
NPA
G
MVTEA
V
YR
HT
G
FK
R
F
IG
V
C
N
I
PIG
MKMF
I
R
DV
L
M
L
K
D
SDD
L
S
I
D
LF
GLNHM
---VF
I
K
D
VLVN
G
K
--
S
R
F
A
ELL
DG
V
A
--------------
-
---S
GQ
L
KA
SG
V
KNI
FDLPFSEGLIR
SM
N
L
LP
C
SYL
L
YY
F
K
Q
K
E
-
MLAI
E
MG
E
Y
YK
G
GARAQ
V
V
Q
KV
EKQLFE
L
YK
N
P
----------
E
L
NVKP
KELE
QRGG
A
YYS
D
A
------
AC
EV
INAI
Y
N
--------
D
K
Q
A
EH
YVN
----------------
I
P
H
HG
H
IDN
I
P
ADWA
VEM
T
C
T
L
G
R
D
G
AT
P
H
P
----
R
I
TH
F
DDKVM
GL
I
H
T
IKG
F
E
I
A
AS
NA
A
L
SGEFND
V
LL
A
LN
LSP
---
L
V
H
S
DRD
A
E
L
L
A
R
E
M
I
L
AH
EK
WLP
NF
ADCIAELKKAH
fig|749528.3.peg.4798
Escherichia coli MS 45-1
MSQK
L
KVV
T
IGGGS
S
Y
TP
EL
L
E
G
F
I
KRYHE
LP
VSE
L
W
L
V
D
V
E
GG
K
AKLDI
I
FDL
CQ
R
M
I
D
N
AG
VPM
K
LYK
T
L
D
R
REAL
K
DADFV
TTQL
RVG
Q
L
-
P
A
RELDERIPL
S
HG
Y
LGQ
---
ET
N
G
A
GG
L
FK
GLRTIP
V
I
F
D
IVKD
V
EE
L
CPNAW
VI
N
F
T
NPA
G
MVTEA
V
YR
HT
G
FK
R
F
IG
V
C
N
I
PIG
MKMF
I
R
DV
L
M
L
K
D
SDD
L
S
I
D
LF
GLNHM
---VF
I
K
D
VLVN
G
K
--
S
R
F
A
ELL
DG
V
A
--------------
-
---S
GQ
L
KA
SG
V
KNI
FDLPFSEGLIR
SM
N
L
LP
C
SYL
L
YY
F
K
Q
K
E
-
MLAI
E
MG
E
Y
YK
G
GARAQ
V
V
Q
KV
EKQLFE
L
YK
N
P
----------
E
L
NVKP
KELE
QRGG
A
YYS
D
A
------
AC
EV
INAI
Y
N
--------
D
K
Q
A
EH
YVN
----------------
I
P
H
HG
H
IDN
I
P
ADWA
VEM
T
C
T
L
G
R
D
G
AT
P
H
P
----
R
I
TH
F
DDKVM
GL
I
H
T
IKG
F
E
I
A
AS
NA
A
L
SGEFND
V
LL
A
LN
LSP
---
L
V
H
S
DRD
A
E
L
L
A
R
E
M
I
L
AH
EK
WLP
NF
ADCIAELKKAH
fig|574521.7.peg.1904
Escherichia coli O127:H6 str. E2348/69
MSQK
L
KVV
T
IGGGS
S
Y
TP
EL
L
E
G
F
I
KRYHE
LP
VSE
L
W
L
V
D
V
E
GG
K
AKLDI
I
FDL
CQ
R
M
I
D
N
AG
VPM
K
LYK
T
L
D
R
REAL
K
DADFV
TTQL
RVG
Q
L
-
P
A
RELDERIPL
S
HG
Y
LGQ
---
ET
N
G
A
GG
L
FK
GLRTIP
V
I
F
D
IVKD
V
EE
L
CPNAW
VI
N
F
T
NPA
G
MVTEA
V
YR
HT
G
FK
R
F
IG
V
C
N
I
PIG
MKMF
I
R
DV
L
M
L
K
D
SDD
L
S
I
D
LF
GLNHM
---VF
I
K
D
VLVN
G
K
--
S
R
F
A
ELL
DG
V
A
--------------
-
---S
GQ
L
KA
SG
V
KNI
FDLPFSEGLIR
SM
N
L
LP
C
SYL
L
YY
F
K
Q
K
E
-
MLAI
E
MG
E
Y
YK
G
GARAQ
V
V
Q
KV
EKQLFE
L
YK
N
P
----------
E
L
NVKP
KELE
QRGG
A
YYS
D
A
------
AC
EV
INAI
Y
N
--------
D
K
Q
A
EH
YVN
----------------
I
P
H
HG
H
IDN
I
P
ADWA
VEM
T
C
T
L
G
R
D
G
AT
P
H
P
----
R
I
TH
F
DDKVM
GL
I
H
T
IKG
F
E
I
A
AS
NA
A
L
SGEFND
V
LL
A
LN
LSP
---
L
V
H
S
DRD
A
E
L
L
A
R
E
M
I
L
AH
EK
WLP
NF
ADCIAELKKAH
fig|562.376.peg.2383
Escherichia coli WV_060327
MSQK
L
KVV
T
IGGGS
S
Y
TP
EL
L
E
G
F
I
KRYHE
LP
VSE
L
W
L
V
D
V
E
GG
K
AKLDI
I
FDL
CQ
R
M
I
D
N
AG
VPM
K
LYK
T
L
D
R
REAL
K
DADFV
TTQL
RVG
Q
L
-
P
A
RELDERIPL
S
HG
Y
LGQ
---
ET
N
G
A
GG
L
FK
GLRTIP
V
I
F
D
IVKD
V
EE
L
CPNAW
VI
N
F
T
NPA
G
MVTEA
V
YR
HT
G
FK
R
F
IG
V
C
N
I
PIG
MKMF
I
R
DV
L
M
L
K
D
SDD
L
S
I
D
LF
GLNHM
---VF
I
K
D
VLVN
G
K
--
S
R
F
A
ELL
DG
V
A
--------------
-
---S
GQ
L
KA
SG
V
KNI
FDLPFSEGLIR
SM
N
L
LP
C
SYL
L
YY
F
K
Q
K
E
-
MLAI
E
MG
E
Y
YK
G
GARAQ
V
V
Q
KV
EKQLFE
L
YK
N
P
----------
E
L
NVKP
KELE
QRGG
A
YYS
D
A
------
AC
EV
INAI
Y
N
--------
D
K
Q
A
EH
YVN
----------------
I
P
H
HG
H
IDN
I
P
ADWA
VEM
T
C
T
L
G
R
D
G
AT
P
H
P
----
R
I
TH
F
DDKVM
GL
I
H
T
IKG
F
E
I
A
AS
NA
A
L
SGEFND
V
LL
A
LN
LSP
---
L
V
H
S
DRD
A
E
L
L
A
R
E
M
I
L
AH
EK
WLP
NF
ADCIAELKKAH
fig|444454.5.peg.1187
Escherichia coli O157:H7 str. EC4024
MSQK
L
KVV
T
IGGGS
S
Y
TP
EL
L
E
G
F
I
KRYHE
LP
VSE
L
W
L
V
D
V
E
GG
K
AKLDI
I
FDL
CQ
R
M
I
D
N
AG
VPM
K
LYK
T
L
D
R
REAL
K
DADFV
TTQL
RVG
Q
L
-
P
A
RELDERIPL
S
HG
Y
LGQ
---
ET
N
G
A
GG
L
FK
GLRTIP
V
I
F
D
IVKD
V
EE
L
CPNAW
VI
N
F
T
NPA
G
MVTEA
V
YR
HT
G
FK
R
F
IG
V
C
N
I
PIG
MKMF
I
R
DV
L
M
L
K
D
SDD
L
S
I
D
LF
GLNHM
---VF
I
K
D
VLVN
G
K
--
S
R
F
A
ELL
DG
V
A
--------------
-
---S
GQ
L
KA
SG
V
KNI
FDLPFSEGLIR
SL
N
L
LP
C
SYL
L
YY
F
K
Q
K
E
-
MLAI
E
MG
E
Y
YK
G
GARAQ
V
V
Q
KV
EKQLFE
L
YK
N
P
----------
E
L
KVKP
KELE
QRGG
A
YYS
D
A
------
AC
EV
INAI
Y
N
--------
D
K
Q
A
EH
YVN
----------------
I
P
H
HG
H
IDN
I
P
ADWA
VEM
T
C
T
L
G
R
D
G
AT
P
H
P
----
R
I
TH
F
DDKVM
GL
I
H
T
IKG
F
E
I
A
AS
NA
A
L
SGEFNG
V
LL
A
LN
LSP
---
L
V
H
S
DRD
A
E
L
L
A
R
E
M
I
L
AH
EK
WLP
NF
ADCIAELKKAH
fig|444449.5.peg.675
Escherichia coli O157:H7 str. EC4042
MSQK
L
KVV
T
IGGGS
S
Y
TP
EL
L
E
G
F
I
KRYHE
LP
VSE
L
W
L
V
D
V
E
GG
K
AKLDI
I
FDL
CQ
R
M
I
D
N
AG
VPM
K
LYK
T
L
D
R
REAL
K
DADFV
TTQL
RVG
Q
L
-
P
A
RELDERIPL
S
HG
Y
LGQ
---
ET
N
G
A
GG
L
FK
GLRTIP
V
I
F
D
IVKD
V
EE
L
CPNAW
VI
N
F
T
NPA
G
MVTEA
V
YR
HT
G
FK
R
F
IG
V
C
N
I
PIG
MKMF
I
R
DV
L
M
L
K
D
SDD
L
S
I
D
LF
GLNHM
---VF
I
K
D
VLVN
G
K
--
S
R
F
A
ELL
DG
V
A
--------------
-
---S
GQ
L
KA
SG
V
KNI
FDLPFSEGLIR
SL
N
L
LP
C
SYL
L
YY
F
K
Q
K
E
-
MLAI
E
MG
E
Y
YK
G
GARAQ
V
V
Q
KV
EKQLFE
L
YK
N
P
----------
E
L
KVKP
KELE
QRGG
A
YYS
D
A
------
AC
EV
INAI
Y
N
--------
D
K
Q
A
EH
YVN
----------------
I
P
H
HG
H
IDN
I
P
ADWA
VEM
T
C
T
L
G
R
D
G
AT
P
H
P
----
R
I
TH
F
DDKVM
GL
I
H
T
IKG
F
E
I
A
AS
NA
A
L
SGEFNG
V
LL
A
LN
LSP
---
L
V
H
S
DRD
A
E
L
L
A
R
E
M
I
L
AH
EK
WLP
NF
ADCIAELKKAH
fig|444448.5.peg.4979
Escherichia coli O157:H7 str. EC4045
MSQK
L
KVV
T
IGGGS
S
Y
TP
EL
L
E
G
F
I
KRYHE
LP
VSE
L
W
L
V
D
V
E
GG
K
AKLDI
I
FDL
CQ
R
M
I
D
N
AG
VPM
K
LYK
T
L
D
R
REAL
K
DADFV
TTQL
RVG
Q
L
-
P
A
RELDERIPL
S
HG
Y
LGQ
---
ET
N
G
A
GG
L
FK
GLRTIP
V
I
F
D
IVKD
V
EE
L
CPNAW
VI
N
F
T
NPA
G
MVTEA
V
YR
HT
G
FK
R
F
IG
V
C
N
I
PIG
MKMF
I
R
DV
L
M
L
K
D
SDD
L
S
I
D
LF
GLNHM
---VF
I
K
D
VLVN
G
K
--
S
R
F
A
ELL
DG
V
A
--------------
-
---S
GQ
L
KA
SG
V
KNI
FDLPFSEGLIR
SL
N
L
LP
C
SYL
L
YY
F
K
Q
K
E
-
MLAI
E
MG
E
Y
YK
G
GARAQ
V
V
Q
KV
EKQLFE
L
YK
N
P
----------
E
L
KVKP
KELE
QRGG
A
YYS
D
A
------
AC
EV
INAI
Y
N
--------
D
K
Q
A
EH
YVN
----------------
I
P
H
HG
H
IDN
I
P
ADWA
VEM
T
C
T
L
G
R
D
G
AT
P
H
P
----
R
I
TH
F
DDKVM
GL
I
H
T
IKG
F
E
I
A
AS
NA
A
L
SGEFNG
V
LL
A
LN
LSP
---
L
V
H
S
DRD
A
E
L
L
A
R
E
M
I
L
AH
EK
WLP
NF
ADCIAELKKAH
fig|444453.5.peg.3533
Escherichia coli O157:H7 str. EC4076
MSQK
L
KVV
T
IGGGS
S
Y
TP
EL
L
E
G
F
I
KRYHE
LP
VSE
L
W
L
V
D
V
E
GG
K
AKLDI
I
FDL
CQ
R
M
I
D
N
AG
VPM
K
LYK
T
L
D
R
REAL
K
DADFV
TTQL
RVG
Q
L
-
P
A
RELDERIPL
S
HG
Y
LGQ
---
ET
N
G
A
GG
L
FK
GLRTIP
V
I
F
D
IVKD
V
EE
L
CPNAW
VI
N
F
T
NPA
G
MVTEA
V
YR
HT
G
FK
R
F
IG
V
C
N
I
PIG
MKMF
I
R
DV
L
M
L
K
D
SDD
L
S
I
D
LF
GLNHM
---VF
I
K
D
VLVN
G
K
--
S
R
F
A
ELL
DG
V
A
--------------
-
---S
GQ
L
KA
SG
V
KNI
FDLPFSEGLIR
SL
N
L
LP
C
SYL
L
YY
F
K
Q
K
E
-
MLAI
E
MG
E
Y
YK
G
GARAQ
V
V
Q
KV
EKQLFE
L
YK
N
P
----------
E
L
KVKP
KELE
QRGG
A
YYS
D
A
------
AC
EV
INAI
Y
N
--------
D
K
Q
A
EH
YVN
----------------
I
P
H
HG
H
IDN
I
P
ADWA
VEM
T
C
T
L
G
R
D
G
AT
P
H
P
----
R
I
TH
F
DDKVM
GL
I
H
T
IKG
F
E
I
A
AS
NA
A
L
SGEFNG
V
LL
A
LN
LSP
---
L
V
H
S
DRD
A
E
L
L
A
R
E
M
I
L
AH
EK
WLP
NF
ADCIAELKKAH
fig|444452.5.peg.2454
Escherichia coli O157:H7 str. EC4113
MSQK
L
KVV
T
IGGGS
S
Y
TP
EL
L
E
G
F
I
KRYHE
LP
VSE
L
W
L
V
D
V
E
GG
K
AKLDI
I
FDL
CQ
R
M
I
D
N
AG
VPM
K
LYK
T
L
D
R
REAL
K
DADFV
TTQL
RVG
Q
L
-
P
A
RELDERIPL
S
HG
Y
LGQ
---
ET
N
G
A
GG
L
FK
GLRTIP
V
I
F
D
IVKD
V
EE
L
CPNAW
VI
N
F
T
NPA
G
MVTEA
V
YR
HT
G
FK
R
F
IG
V
C
N
I
PIG
MKMF
I
R
DV
L
M
L
K
D
SDD
L
S
I
D
LF
GLNHM
---VF
I
K
D
VLVN
G
K
--
S
R
F
A
ELL
DG
V
A
--------------
-
---S
GQ
L
KA
SG
V
KNI
FDLPFSEGLIR
SL
N
L
LP
C
SYL
L
YY
F
K
Q
K
E
-
MLAI
E
MG
E
Y
YK
G
GARAQ
V
V
Q
KV
EKQLFE
L
YK
N
P
----------
E
L
KVKP
KELE
QRGG
A
YYS
D
A
------
AC
EV
INAI
Y
N
--------
D
K
Q
A
EH
YVN
----------------
I
P
H
HG
H
IDN
I
P
ADWA
VEM
T
C
T
L
G
R
D
G
AT
P
H
P
----
R
I
TH
F
DDKVM
GL
I
H
T
IKG
F
E
I
A
AS
NA
A
L
SGEFNG
V
LL
A
LN
LSP
---
L
V
H
S
DRD
A
E
L
L
A
R
E
M
I
L
AH
EK
WLP
NF
ADCIAELKKAH
fig|444450.8.peg.2490
Escherichia coli O157:H7 str. EC4115
MSQK
L
KVV
T
IGGGS
S
Y
TP
EL
L
E
G
F
I
KRYHE
LP
VSE
L
W
L
V
D
V
E
GG
K
AKLDI
I
FDL
CQ
R
M
I
D
N
AG
VPM
K
LYK
T
L
D
R
REAL
K
DADFV
TTQL
RVG
Q
L
-
P
A
RELDERIPL
S
HG
Y
LGQ
---
ET
N
G
A
GG
L
FK
GLRTIP
V
I
F
D
IVKD
V
EE
L
CPNAW
VI
N
F
T
NPA
G
MVTEA
V
YR
HT
G
FK
R
F
IG
V
C
N
I
PIG
MKMF
I
R
DV
L
M
L
K
D
SDD
L
S
I
D
LF
GLNHM
---VF
I
K
D
VLVN
G
K
--
S
R
F
A
ELL
DG
V
A
--------------
-
---S
GQ
L
KA
SG
V
KNI
FDLPFSEGLIR
SL
N
L
LP
C
SYL
L
YY
F
K
Q
K
E
-
MLAI
E
MG
E
Y
YK
G
GARAQ
V
V
Q
KV
EKQLFE
L
YK
N
P
----------
E
L
KVKP
KELE
QRGG
A
YYS
D
A
------
AC
EV
INAI
Y
N
--------
D
K
Q
A
EH
YVN
----------------
I
P
H
HG
H
IDN
I
P
ADWA
VEM
T
C
T
L
G
R
D
G
AT
P
H
P
----
R
I
TH
F
DDKVM
GL
I
H
T
IKG
F
E
I
A
AS
NA
A
L
SGEFNG
V
LL
A
LN
LSP
---
L
V
H
S
DRD
A
E
L
L
A
R
E
M
I
L
AH
EK
WLP
NF
ADCIAELKKAH
fig|444451.5.peg.2592
Escherichia coli O157:H7 str. EC4196
MSQK
L
KVV
T
IGGGS
S
Y
TP
EL
L
E
G
F
I
KRYHE
LP
VSE
L
W
L
V
D
V
E
GG
K
AKLDI
I
FDL
CQ
R
M
I
D
N
AG
VPM
K
LYK
T
L
D
R
REAL
K
DADFV
TTQL
RVG
Q
L
-
P
A
RELDERIPL
S
HG
Y
LGQ
---
ET
N
G
A
GG
L
FK
GLRTIP
V
I
F
D
IVKD
V
EE
L
CPNAW
VI
N
F
T
NPA
G
MVTEA
V
YR
HT
G
FK
R
F
IG
V
C
N
I
PIG
MKMF
I
R
DV
L
M
L
K
D
SDD
L
S
I
D
LF
GLNHM
---VF
I
K
D
VLVN
G
K
--
S
R
F
A
ELL
DG
V
A
--------------
-
---S
GQ
L
KA
SG
V
KNI
FDLPFSEGLIR
SL
N
L
LP
C
SYL
L
YY
F
K
Q
K
E
-
MLAI
E
MG
E
Y
YK
G
GARAQ
V
V
Q
KV
EKQLFE
L
YK
N
P
----------
E
L
KVKP
KELE
QRGG
A
YYS
D
A
------
AC
EV
INAI
Y
N
--------
D
K
Q
A
EH
YVN
----------------
I
P
H
HG
H
IDN
I
P
ADWA
VEM
T
C
T
L
G
R
D
G
AT
P
H
P
----
R
I
TH
F
DDKVM
GL
I
H
T
IKG
F
E
I
A
AS
NA
A
L
SGEFNG
V
LL
A
LN
LSP
---
L
V
H
S
DRD
A
E
L
L
A
R
E
M
I
L
AH
EK
WLP
NF
ADCIAELKKAH
fig|444447.5.peg.5009
Escherichia coli O157:H7 str. EC4206
MSQK
L
KVV
T
IGGGS
S
Y
TP
EL
L
E
G
F
I
KRYHE
LP
VSE
L
W
L
V
D
V
E
GG
K
AKLDI
I
FDL
CQ
R
M
I
D
N
AG
VPM
K
LYK
T
L
D
R
REAL
K
DADFV
TTQL
RVG
Q
L
-
P
A
RELDERIPL
S
HG
Y
LGQ
---
ET
N
G
A
GG
L
FK
GLRTIP
V
I
F
D
IVKD
V
EE
L
CPNAW
VI
N
F
T
NPA
G
MVTEA
V
YR
HT
G
FK
R
F
IG
V
C
N
I
PIG
MKMF
I
R
DV
L
M
L
K
D
SDD
L
S
I
D
LF
GLNHM
---VF
I
K
D
VLVN
G
K
--
S
R
F
A
ELL
DG
V
A
--------------
-
---S
GQ
L
KA
SG
V
KNI
FDLPFSEGLIR
SL
N
L
LP
C
SYL
L
YY
F
K
Q
K
E
-
MLAI
E
MG
E
Y
YK
G
GARAQ
V
V
Q
KV
EKQLFE
L
YK
N
P
----------
E
L
KVKP
KELE
QRGG
A
YYS
D
A
------
AC
EV
INAI
Y
N
--------
D
K
Q
A
EH
YVN
----------------
I
P
H
HG
H
IDN
I
P
ADWA
VEM
T
C
T
L
G
R
D
G
AT
P
H
P
----
R
I
TH
F
DDKVM
GL
I
H
T
IKG
F
E
I
A
AS
NA
A
L
SGEFNG
V
LL
A
LN
LSP
---
L
V
H
S
DRD
A
E
L
L
A
R
E
M
I
L
AH
EK
WLP
NF
ADCIAELKKAH
fig|478004.5.peg.3438
Escherichia coli O157:H7 str. EC4401
MSQK
L
KVV
T
IGGGS
S
Y
TP
EL
L
E
G
F
I
KRYHE
LP
VSE
L
W
L
V
D
V
E
GG
K
AKLDI
I
FDL
CQ
R
M
I
D
N
AG
VPM
K
LYK
T
L
D
R
REAL
K
DADFV
TTQL
RVG
Q
L
-
P
A
RELDERIPL
S
HG
Y
LGQ
---
ET
N
G
A
GG
L
FK
GLRTIP
V
I
F
D
IVKD
V
EE
L
CPNAW
VI
N
F
T
NPA
G
MVTEA
V
YR
HT
G
FK
R
F
IG
V
C
N
I
PIG
MKMF
I
R
DV
L
M
L
K
D
SDD
L
S
I
D
LF
GLNHM
---VF
I
K
D
VLVN
G
K
--
S
R
F
A
ELL
DG
V
A
--------------
-
---S
GQ
L
KA
SG
V
KNI
FDLPFSEGLIR
SL
N
L
LP
C
SYL
L
YY
F
K
Q
K
E
-
MLAI
E
MG
E
Y
YK
G
GARAQ
V
V
Q
KV
EKQLFE
L
YK
N
P
----------
E
L
KVKP
KELE
QRGG
A
YYS
D
A
------
AC
EV
INAI
Y
N
--------
D
K
Q
A
EH
YVN
----------------
I
P
H
HG
H
IDN
I
P
ADWA
VEM
T
C
T
L
G
R
D
G
AT
P
H
P
----
R
I
TH
F
DDKVM
GL
I
H
T
IKG
F
E
I
A
AS
NA
A
L
SGEFNG
V
LL
A
LN
LSP
---
L
V
H
S
DRD
A
E
L
L
A
R
E
M
I
L
AH
EK
WLP
NF
ADCIAELKKAH
fig|478005.5.peg.4292
Escherichia coli O157:H7 str. EC4486
MSQK
L
KVV
T
IGGGS
S
Y
TP
EL
L
E
G
F
I
KRYHE
LP
VSE
L
W
L
V
D
V
E
GG
K
AKLDI
I
FDL
CQ
R
M
I
D
N
AG
VPM
K
LYK
T
L
D
R
REAL
K
DADFV
TTQL
RVG
Q
L
-
P
A
RELDERIPL
S
HG
Y
LGQ
---
ET
N
G
A
GG
L
FK
GLRTIP
V
I
F
D
IVKD
V
EE
L
CPNAW
VI
N
F
T
NPA
G
MVTEA
V
YR
HT
G
FK
R
F
IG
V
C
N
I
PIG
MKMF
I
R
DV
L
M
L
K
D
SDD
L
S
I
D
LF
GLNHM
---VF
I
K
D
VLVN
G
K
--
S
R
F
A
ELL
DG
V
A
--------------
-
---S
GQ
L
KA
SG
V
KNI
FDLPFSEGLIR
SL
N
L
LP
C
SYL
L
YY
F
K
Q
K
E
-
MLAI
E
MG
E
Y
YK
G
GARAQ
V
V
Q
KV
EKQLFE
L
YK
N
P
----------
E
L
KVKP
KELE
QRGG
A
YYS
D
A
------
AC
EV
INAI
Y
N
--------
D
K
Q
A
EH
YVN
----------------
I
P
H
HG
H
IDN
I
P
ADWA
VEM
T
C
T
L
G
R
D
G
AT
P
H
P
----
R
I
TH
F
DDKVM
GL
I
H
T
IKG
F
E
I
A
AS
NA
A
L
SGEFNG
V
LL
A
LN
LSP
---
L
V
H
S
DRD
A
E
L
L
A
R
E
M
I
L
AH
EK
WLP
NF
ADCIAELKKAH
fig|544404.4.peg.2352
Escherichia coli O157:H7 str. TW14359
MSQK
L
KVV
T
IGGGS
S
Y
TP
EL
L
E
G
F
I
KRYHE
LP
VSE
L
W
L
V
D
V
E
GG
K
AKLDI
I
FDL
CQ
R
M
I
D
N
AG
VPM
K
LYK
T
L
D
R
REAL
K
DADFV
TTQL
RVG
Q
L
-
P
A
RELDERIPL
S
HG
Y
LGQ
---
ET
N
G
A
GG
L
FK
GLRTIP
V
I
F
D
IVKD
V
EE
L
CPNAW
VI
N
F
T
NPA
G
MVTEA
V
YR
HT
G
FK
R
F
IG
V
C
N
I
PIG
MKMF
I
R
DV
L
M
L
K
D
SDD
L
S
I
D
LF
GLNHM
---VF
I
K
D
VLVN
G
K
--
S
R
F
A
ELL
DG
V
A
--------------
-
---S
GQ
L
KA
SG
V
KNI
FDLPFSEGLIR
SL
N
L
LP
C
SYL
L
YY
F
K
Q
K
E
-
MLAI
E
MG
E
Y
YK
G
GARAQ
V
V
Q
KV
EKQLFE
L
YK
N
P
----------
E
L
KVKP
KELE
QRGG
A
YYS
D
A
------
AC
EV
INAI
Y
N
--------
D
K
Q
A
EH
YVN
----------------
I
P
H
HG
H
IDN
I
P
ADWA
VEM
T
C
T
L
G
R
D
G
AT
P
H
P
----
R
I
TH
F
DDKVM
GL
I
H
T
IKG
F
E
I
A
AS
NA
A
L
SGEFNG
V
LL
A
LN
LSP
---
L
V
H
S
DRD
A
E
L
L
A
R
E
M
I
L
AH
EK
WLP
NF
ADCIAELKKAH
fig|749531.3.peg.354
Escherichia coli MS 69-1
MSQK
L
KVV
T
IGGGS
S
Y
TP
EL
L
E
G
F
I
KRYHE
LP
VSE
L
W
L
V
D
V
E
GG
K
AKLDI
I
FDL
CQ
R
M
I
D
N
AG
IPM
K
LYK
T
L
D
R
REAL
K
DADFV
TTQL
RVG
Q
L
-
P
A
RELDERIPL
S
HG
Y
LGQ
---
ET
N
G
A
GG
L
FK
GLRTIP
V
I
F
D
IVKD
V
EE
L
CPNAW
VI
N
F
T
NPA
G
MVTEA
V
YR
HT
G
FK
R
F
IG
V
C
N
I
PIG
MKMF
I
R
DV
L
M
L
K
D
SDD
L
S
I
D
LF
GLNHM
---VF
I
K
D
VLVN
G
K
--
S
R
F
A
ELL
DG
V
A
--------------
-
---S
GQ
L
KA
SG
V
KNI
FDLPFSEGLIR
SL
N
L
LP
C
SYL
L
YY
F
K
Q
K
E
-
MLAI
E
MG
E
Y
YK
G
GARAQ
V
V
Q
KV
EKQLFE
L
YK
N
S
----------
E
L
KVKP
KELE
QRGG
A
YYS
D
A
------
AC
EV
INAI
Y
N
--------
D
K
Q
A
EH
YVN
----------------
I
P
H
HG
H
IDN
I
P
ADWA
VEM
T
C
T
L
G
R
D
G
AT
P
H
P
----
R
I
TH
F
DDKVM
GL
I
H
T
IKG
F
E
I
A
AS
NA
A
L
SGEFND
V
LL
A
LN
LSP
---
L
V
H
S
DRD
A
E
L
L
A
R
E
M
I
L
AH
EK
WLP
NF
ADCIAELKKAH
fig|656419.3.peg.2449
Escherichia coli M718
M
R
QK
L
KVV
T
IGGGS
S
Y
TP
EL
L
E
G
F
I
KRYHE
LP
VSE
L
W
L
V
D
V
E
GG
K
AKLDI
I
FDL
CQ
R
M
I
D
N
AG
VPM
K
LYK
T
L
D
R
REAL
K
DADFV
TTQL
RVG
Q
L
-
P
A
RELDERIPL
S
HG
Y
LGQ
---
ET
N
G
A
GG
L
FK
GLRTIP
V
I
F
D
IVKD
V
EE
L
CPNAW
VI
N
F
T
NPA
G
MVTEA
V
YR
HT
G
FK
R
F
IG
V
C
N
I
PIG
MKMF
I
R
DV
L
M
L
K
D
SDD
L
S
I
D
LF
GLNHM
---VF
I
K
D
VLVN
G
K
--
S
R
F
A
ELL
DG
V
A
--------------
-
---S
GQ
L
KA
SG
V
KNI
FDLPFSEGLIR
SL
N
L
LP
C
SYL
L
YY
F
K
Q
K
E
-
MLAI
E
MG
E
Y
YK
G
GARAQ
V
V
Q
KV
EKQLFE
L
YK
N
P
----------
E
L
KVKP
KELE
QRGG
A
YYS
D
A
------
AC
EV
INAI
Y
N
--------
D
K
Q
A
EH
YVN
----------------
I
P
H
HG
H
IDN
I
P
ADWA
VEM
T
Y
T
L
G
R
D
G
AT
P
H
P
----
R
I
TH
F
DDKVM
GL
I
H
T
IKG
F
E
I
A
AS
NA
A
L
SGEFND
V
LL
A
LN
LSP
---
L
V
H
S
DRD
A
E
L
L
A
R
E
M
I
L
AH
EK
WLP
NF
ADCIAELKKAH
fig|656437.3.peg.4163
Escherichia coli TA143 (3-439/440)
K
F
S
VV
V
A
GGGST
F
TP
GI
V
L
M
L
L
ANQDR
F
P
LRA
L
K
F
Y
D
N
D
GA
R
Q--EV
I
AEA
C
K
V
IL
K
E
KA
PDI
A
FSY
TTD
P
E
V
A
F
S
D
V
DFV
MAHI
RVG
K
Y
-
P
M
RELDE
K
IPLRHG
V
V
GQ
---
ET
C
GPGGI
AY
G
M
R
S
I
G
G
V
L
E
L
V
D
Y
ME
K
Y
S
PNAWMLNY
S
NPAA
I
V
A
EA
T
R
R
LR
P
NA
K
I
L
N
I
C
D
M
PIG
IESR
M
A
QI
V
G
L
Q
D
RKQ
M
R
V
R
YY
GLNH
F
GWWTS
IED
--LQ
G
N
--
D
L
M
P
Q
L
R
QY
V
S
KHGYVPPQQDTHTE
A
SWND
TY
AKA
RD
V
QAL
-----------
DP
D
TLP
N
T
YL
K
YY
L
F
P
D
Y
-
VVQH
S
NP
EH
TR
A
N---E
V
ME
HR
EKQ
V
F
D
-
--
-
-
----------
-
-
----
----
----
-
---
-
-
------
AC
RA
I
T
A
A
E
N
SAAGKLEI
DE
H
A
SY
I
V
DLAAAIAFNTQERMLLI
VPN
N
G
A
I
H
N
F
D
DEAM
VE
I
P
C
L
VG
H
NG
--
P
E
P
LVVG
D
I
PQ
F
QK---
GLM
S
Q
QVA
VE
K
L
VV
D
A
W
E
QRSYQH
L
WQ
A
IT
LS
K
---
T
V
P
S
ASV
A
K
A
I
L
DEL
L
E
A
N
KA
YW
P
EL
fig|656379.3.peg.4538
Escherichia coli FVEC1302 (3-439/440)
K
F
S
VV
V
A
GGGST
F
TP
GI
V
L
M
L
L
ANQDR
F
P
LRA
L
K
F
Y
D
N
D
GA
R
Q--EV
I
AEA
C
K
V
IL
K
E
KA
PDI
A
FSY
TTD
P
E
V
A
F
S
D
V
DFV
MAHI
RVG
K
Y
-
P
M
RELDE
K
IPLRHG
V
V
GQ
---
ET
C
GPGGI
AY
G
M
R
S
I
G
G
V
L
E
L
V
D
Y
ME
K
Y
S
PNAWMLNY
S
NPAA
I
V
A
EA
T
R
R
LR
P
NA
K
I
L
N
I
C
D
M
PIG
IESR
M
A
QI
V
G
L
Q
D
RKQ
M
R
V
R
YY
GLNH
F
GWWTS
IED
--LQ
G
N
--
D
L
M
P
Q
L
R
QY
V
S
KHGYVPPQQDTHTE
A
SWND
TY
AKA
RD
V
QAL
-----------
DP
D
TLP
N
T
YL
K
YY
L
F
P
D
Y
-
VVQH
S
NP
EH
TR
A
N---E
V
ME
HR
EKQ
V
F
D
-
--
-
-
----------
-
-
----
----
----
-
---
-
-
------
AC
RA
I
T
A
A
E
N
SAAGKLEI
DE
H
A
SY
I
V
DLAAAIAFNTQERMLLI
VPN
N
G
A
I
H
N
F
D
DEAM
VE
I
P
C
L
VG
H
NG
--
P
E
P
LVVG
D
I
PQ
F
QK---
GLM
S
Q
QVA
VE
K
L
VV
D
A
W
E
QRSYQH
L
WQ
A
IT
LS
K
---
T
V
P
S
AAV
A
K
A
I
L
DEL
L
E
A
N
KA
YW
P
EL
fig|656380.3.peg.4822
Escherichia coli FVEC1412 (3-439/440)
K
F
S
VV
V
A
GGGST
F
TP
GI
V
L
M
L
L
ANQDR
F
P
LRA
L
K
F
Y
D
N
D
GA
R
Q--EV
I
AEA
C
K
V
IL
K
E
KA
PDI
A
FSY
TTD
P
E
V
A
F
S
D
V
DFV
MAHI
RVG
K
Y
-
P
M
RELDE
K
IPLRHG
V
V
GQ
---
ET
C
GPGGI
AY
G
M
R
S
I
G
G
V
L
E
L
V
D
Y
ME
K
Y
S
PNAWMLNY
S
NPAA
I
V
A
EA
T
R
R
LR
P
NA
K
I
L
N
I
C
D
M
PIG
IESR
M
A
QI
V
G
L
Q
D
RKQ
M
R
V
R
YY
GLNH
F
GWWTS
IED
--LQ
G
N
--
D
L
M
P
Q
L
R
QY
V
S
KHGYVPPQQDTHTE
A
SWND
TY
AKA
RD
V
QAL
-----------
DP
D
TLP
N
T
YL
K
YY
L
F
P
D
Y
-
VVQH
S
NP
EH
TR
A
N---E
V
ME
HR
EKQ
V
F
D
-
--
-
-
----------
-
-
----
----
----
-
---
-
-
------
AC
RA
I
T
A
A
E
N
SAAGKLEI
DE
H
A
SY
I
V
DLAAAIAFNTQERMLLI
VPN
N
G
A
I
H
N
F
D
DEAM
VE
I
P
C
L
VG
H
NG
--
P
E
P
LVVG
D
I
PQ
F
QK---
GLM
S
Q
QVA
VE
K
L
VV
D
A
W
E
QRSYQH
L
WQ
A
IT
LS
K
---
T
V
P
S
AAV
A
K
A
I
L
DEL
L
E
A
N
KA
YW
P
EL
fig|749549.3.peg.338
Escherichia coli MS 198-1 (3-439/440)
K
F
S
VV
V
A
GGGST
F
TP
GI
V
L
M
L
L
ANQDR
F
P
LRA
L
K
F
Y
D
N
D
GA
R
Q--EV
I
AEA
C
K
V
IL
K
E
KA
PDI
A
FSY
TTD
P
E
V
A
F
S
D
V
DFV
MAHI
RVG
K
Y
-
P
M
RELDE
K
IPLRHG
V
V
GQ
---
ET
C
GPGGI
AY
G
M
R
S
I
G
G
V
L
E
L
V
D
Y
ME
K
Y
S
PNAWMLNY
S
NPAA
I
V
A
EA
T
R
R
LR
P
NA
K
I
L
N
I
C
D
M
PIG
IESR
M
A
QI
V
G
L
Q
D
RKQ
M
R
V
R
YY
GLNH
F
GWWTS
IED
--LQ
G
N
--
D
L
M
P
Q
L
R
QY
V
S
KHGYVPPQQDTHTE
A
SWND
TY
AKA
RD
V
QAL
-----------
DP
D
TLP
N
T
YL
K
YY
L
F
P
D
Y
-
VVQH
S
NP
EH
TR
A
N---E
V
ME
HR
EKQ
V
F
D
-
--
-
-
----------
-
-
----
----
----
-
---
-
-
------
AC
RA
I
T
A
A
E
N
SAAGKLEI
DE
H
A
SY
I
V
DLAAAIAFNTQERMLLI
VPN
N
G
A
I
H
N
F
D
DEAM
VE
I
P
C
L
VG
H
NG
--
P
E
P
LVVG
D
I
PQ
F
QK---
GLM
S
Q
QVA
VE
K
L
VV
D
A
W
E
QRSYQH
L
WQ
A
IT
LS
K
---
T
V
P
S
AAV
A
K
A
I
L
DEL
L
E
A
N
KA
YW
P
EL
fig|749531.3.peg.4782
Escherichia coli MS 69-1 (3-439/440)
K
F
S
VV
V
A
GGGST
F
TP
GI
V
L
M
L
L
ANQDR
F
P
LRA
L
K
F
Y
D
N
D
GA
R
Q--EV
I
AEA
C
K
V
IL
K
E
KA
PDI
A
FSY
TTD
P
E
V
A
F
S
D
V
DFV
MAHI
RVG
K
Y
-
P
M
RELDE
K
IPLRHG
V
V
GQ
---
ET
C
GPGGI
AY
G
M
R
S
I
G
G
V
L
E
L
V
D
Y
ME
K
Y
S
PNAWMLNY
S
NPAA
I
V
A
EA
T
R
R
LR
P
NA
K
I
L
N
I
C
D
M
PIG
IESR
M
A
QI
V
G
L
Q
D
RKQ
M
R
V
R
YY
GLNH
F
GWWTS
IED
--LQ
G
N
--
D
L
M
P
Q
L
R
QY
V
S
KHGYVPPQQDTHTE
A
SWND
TY
AKA
RD
V
QAL
-----------
DP
D
TLP
N
T
YL
K
YY
L
F
P
D
Y
-
VVQH
S
NP
EH
TR
A
N---E
V
ME
HR
EKQ
V
F
D
-
--
-
-
----------
-
-
----
----
----
-
---
-
-
------
AC
RA
I
T
A
A
E
N
SAAGKLEI
DE
H
A
SY
I
V
DLAAAIAFNTQERMLLI
VPN
N
G
A
I
H
N
F
D
DEAM
VE
I
P
C
L
VG
H
NG
--
P
E
P
LVVG
D
I
PQ
F
QK---
GLM
S
Q
QVA
VE
K
L
VV
D
A
W
E
QRSYQH
L
WQ
A
IT
LS
K
---
T
V
P
S
AAV
A
K
A
I
L
DEL
L
E
A
N
KA
YW
P
EL
fig|585056.7.peg.4383
Escherichia coli UMN026 (3-439/440)
K
F
S
VV
V
A
GGGST
F
TP
GI
V
L
M
L
L
ANQDR
F
P
LRA
L
K
F
Y
D
N
D
GA
R
Q--EV
I
AEA
C
K
V
IL
K
E
KA
PDI
A
FSY
TTD
P
E
V
A
F
S
D
V
DFV
MAHI
RVG
K
Y
-
P
M
RELDE
K
IPLRHG
V
V
GQ
---
ET
C
GPGGI
AY
G
M
R
S
I
G
G
V
L
E
L
V
D
Y
ME
K
Y
S
PNAWMLNY
S
NPAA
I
V
A
EA
T
R
R
LR
P
NA
K
I
L
N
I
C
D
M
PIG
IESR
M
A
QI
V
G
L
Q
D
RKQ
M
R
V
R
YY
GLNH
F
GWWTS
IED
--LQ
G
N
--
D
L
M
P
Q
L
R
QY
V
S
KHGYVPPQQDTHTE
A
SWND
TY
AKA
RD
V
QAL
-----------
DP
D
TLP
N
T
YL
K
YY
L
F
P
D
Y
-
VVQH
S
NP
EH
TR
A
N---E
V
ME
HR
EKQ
V
F
D
-
--
-
-
----------
-
-
----
----
----
-
---
-
-
------
AC
RA
I
T
A
A
E
N
SAAGKLEI
DE
H
A
SY
I
V
DLAAAIAFNTQERMLLI
VPN
N
G
A
I
H
N
F
D
DEAM
VE
I
P
C
L
VG
H
NG
--
P
E
P
LVVG
D
I
PQ
F
QK---
GLM
S
Q
QVA
VE
K
L
VV
D
A
W
E
QRSYQH
L
WQ
A
IT
LS
K
---
T
V
P
S
AAV
A
K
A
I
L
DEL
L
E
A
N
KA
YW
P
EL
fig|216592.1.peg.1029
Escherichia coli 042 (3-439/440)
K
F
S
VV
V
A
GGGST
F
TP
GI
V
L
M
L
L
ANQDR
F
P
LRA
L
K
F
Y
D
N
D
GA
R
Q--EV
I
AEA
C
K
V
IL
K
E
KA
PDI
A
FSY
TTD
P
E
V
A
F
S
D
V
DFV
MAYI
RVG
K
Y
-
P
M
RELDE
K
IPLRHG
V
V
GQ
---
ET
C
GPGGI
AY
G
M
R
S
I
G
G
V
L
E
L
V
D
Y
ME
K
Y
S
PNAWMLNY
S
NPAA
I
V
A
EA
T
R
R
LR
P
NA
K
I
L
N
I
C
D
M
PIG
IESR
M
A
QI
V
G
L
Q
D
RKQ
M
R
V
R
YY
GLNH
F
GWWTS
IED
--LQ
G
N
--
D
L
M
P
Q
L
R
QY
V
S
KHGYVPPQQDTHTE
A
SWND
TY
AKA
RD
V
QAL
-----------
DP
D
TLP
N
T
YL
K
YY
L
F
P
D
Y
-
VVQH
S
NP
EH
TR
A
N---E
V
ME
HR
EKQ
V
F
D
-
--
-
-
----------
-
-
----
----
----
-
---
-
-
------
AC
RA
I
T
A
A
E
N
SAAGKLEI
DE
H
A
SY
I
V
DLAAAIAFNTQERMLLI
VPN
N
G
A
I
H
N
F
D
DEAM
VE
I
P
C
L
VG
H
NG
--
P
E
P
LVVG
D
I
PQ
F
QK---
GLM
S
Q
QVA
VE
K
L
VV
D
A
W
E
QRSYQH
L
WQ
A
IT
LS
K
---
T
V
P
S
ASV
A
K
A
I
L
DEL
L
E
A
N
KA
YW
P
EL
fig|216592.3.peg.4188
Escherichia coli 042 (3-439/440)
K
F
S
VV
V
A
GGGST
F
TP
GI
V
L
M
L
L
ANQDR
F
P
LRA
L
K
F
Y
D
N
D
GA
R
Q--EV
I
AEA
C
K
V
IL
K
E
KA
PDI
A
FSY
TTD
P
E
V
A
F
S
D
V
DFV
MAYI
RVG
K
Y
-
P
M
RELDE
K
IPLRHG
V
V
GQ
---
ET
C
GPGGI
AY
G
M
R
S
I
G
G
V
L
E
L
V
D
Y
ME
K
Y
S
PNAWMLNY
S
NPAA
I
V
A
EA
T
R
R
LR
P
NA
K
I
L
N
I
C
D
M
PIG
IESR
M
A
QI
V
G
L
Q
D
RKQ
M
R
V
R
YY
GLNH
F
GWWTS
IED
--LQ
G
N
--
D
L
M
P
Q
L
R
QY
V
S
KHGYVPPQQDTHTE
A
SWND
TY
AKA
RD
V
QAL
-----------
DP
D
TLP
N
T
YL
K
YY
L
F
P
D
Y
-
VVQH
S
NP
EH
TR
A
N---E
V
ME
HR
EKQ
V
F
D
-
--
-
-
----------
-
-
----
----
----
-
---
-
-
------
AC
RA
I
T
A
A
E
N
SAAGKLEI
DE
H
A
SY
I
V
DLAAAIAFNTQERMLLI
VPN
N
G
A
I
H
N
F
D
DEAM
VE
I
P
C
L
VG
H
NG
--
P
E
P
LVVG
D
I
PQ
F
QK---
GLM
S
Q
QVA
VE
K
L
VV
D
A
W
E
QRSYQH
L
WQ
A
IT
LS
K
---
T
V
P
S
ASV
A
K
A
I
L
DEL
L
E
A
N
KA
YW
P
EL
fig|585057.4.peg.4418
Escherichia coli IAI39 (3-439/440)
K
F
S
VV
V
A
GGGST
F
TP
GI
V
L
M
L
L
ANQDR
F
P
LRA
L
K
F
Y
D
N
D
GA
R
Q--EV
I
AEA
C
K
V
IL
K
E
KA
PDI
A
FSY
TTD
P
E
V
A
F
S
D
V
DFV
MAHI
RVG
K
Y
-
P
M
RELDE
K
IPLRHG
V
V
GQ
---
ET
C
GPGGI
AY
G
M
R
S
I
G
G
V
L
E
L
V
D
Y
ME
K
Y
S
PNAWMLNY
S
NPAA
I
V
A
EA
T
R
R
LR
P
NA
K
I
L
N
I
C
D
M
PIG
IESR
M
A
QI
V
G
L
Q
D
RKQ
M
R
V
R
YY
GLNH
F
GWWTS
IED
--LQ
G
N
--
D
L
M
P
Q
L
R
QY
V
S
KHGYVPPQQDTHTE
A
SWND
TY
AKA
RD
V
QAL
-----------
DP
D
TLP
N
T
YL
K
YY
L
F
P
D
Y
-
VVQH
S
NP
EH
TR
A
N---E
V
ME
HR
EKQ
V
F
D
-
--
-
-
----------
-
-
----
----
----
-
---
-
-
------
AC
RA
I
T
A
A
G
N
SAAGKLEI
DE
H
A
SY
I
V
DLAAAIAFNTQERMLLI
VPN
N
G
A
I
H
N
F
D
DEAM
VE
I
P
C
L
VG
H
NG
--
P
E
P
LVVG
E
I
PQ
F
QK---
GLM
S
Q
QVA
VE
K
L
VV
D
A
W
E
QRSYQH
L
WQ
A
IT
LS
K
---
T
V
P
S
AAV
A
K
A
I
L
DEL
L
E
A
N
KA
YW
P
EL
fig|585057.6.peg.4428
Escherichia coli IAI39 (3-439/440)
K
F
S
VV
V
A
GGGST
F
TP
GI
V
L
M
L
L
ANQDR
F
P
LRA
L
K
F
Y
D
N
D
GA
R
Q--EV
I
AEA
C
K
V
IL
K
E
KA
PDI
A
FSY
TTD
P
E
V
A
F
S
D
V
DFV
MAHI
RVG
K
Y
-
P
M
RELDE
K
IPLRHG
V
V
GQ
---
ET
C
GPGGI
AY
G
M
R
S
I
G
G
V
L
E
L
V
D
Y
ME
K
Y
S
PNAWMLNY
S
NPAA
I
V
A
EA
T
R
R
LR
P
NA
K
I
L
N
I
C
D
M
PIG
IESR
M
A
QI
V
G
L
Q
D
RKQ
M
R
V
R
YY
GLNH
F
GWWTS
IED
--LQ
G
N
--
D
L
M
P
Q
L
R
QY
V
S
KHGYVPPQQDTHTE
A
SWND
TY
AKA
RD
V
QAL
-----------
DP
D
TLP
N
T
YL
K
YY
L
F
P
D
Y
-
VVQH
S
NP
EH
TR
A
N---E
V
ME
HR
EKQ
V
F
D
-
--
-
-
----------
-
-
----
----
----
-
---
-
-
------
AC
RA
I
T
A
A
G
N
SAAGKLEI
DE
H
A
SY
I
V
DLAAAIAFNTQERMLLI
VPN
N
G
A
I
H
N
F
D
DEAM
VE
I
P
C
L
VG
H
NG
--
P
E
P
LVVG
E
I
PQ
F
QK---
GLM
S
Q
QVA
VE
K
L
VV
D
A
W
E
QRSYQH
L
WQ
A
IT
LS
K
---
T
V
P
S
AAV
A
K
A
I
L
DEL
L
E
A
N
KA
YW
P
EL
fig|83334.1.peg.4593
Escherichia coli O157:H7 (3-439/440)
K
F
S
VV
V
A
GGGST
F
TP
GI
V
L
M
L
L
ANQDR
F
P
LRA
L
K
F
Y
D
N
D
GS
R
Q--EV
I
AEA
C
K
V
IL
K
E
KA
PDI
A
FSY
TTD
P
E
V
A
F
S
D
V
DFV
MAHI
RVG
K
Y
-
P
M
RELDE
K
IPLRHG
V
V
GQ
---
ET
C
GPGGI
AY
G
M
R
S
I
G
G
V
L
E
L
V
D
Y
ME
K
Y
S
PNAWMLNY
S
NPAA
I
V
A
EA
T
R
R
LR
P
NA
K
I
L
N
I
C
D
M
PIG
IESR
M
A
QI
V
G
L
Q
D
RKQ
M
R
V
R
YY
GLNH
F
GWWTS
IED
--LQ
G
N
--
D
L
M
H
Q
L
R
QY
V
S
KHGYVPPQQDTHTE
A
SWND
TY
AKA
RD
V
QAL
-----------
DP
D
TLP
N
T
YL
K
YY
L
F
P
D
Y
-
VVQH
S
NP
EH
TR
A
N---E
V
ME
HR
EKQ
V
F
D
-
--
-
-
----------
-
-
----
----
----
-
---
-
-
------
A
S
RA
I
T
A
A
G
N
SAAGKLEI
DE
H
A
SY
I
V
DLAAAIAFNTQERMLLI
VPN
N
G
A
I
H
N
F
D
DEAM
VE
I
P
C
L
VG
H
NG
--
P
E
P
LVVG
D
I
PQ
F
QK---
GLM
S
Q
QVA
VE
K
L
VV
D
A
W
E
QRSYQH
L
WQ
A
IT
LS
K
---
T
V
P
S
ASV
A
K
A
I
L
DEL
L
E
A
N
KA
YW
P
EL
fig|386585.9.peg.4828
Escherichia coli O157:H7 str. Sakai (3-439/440)
K
F
S
VV
V
A
GGGST
F
TP
GI
V
L
M
L
L
ANQDR
F
P
LRA
L
K
F
Y
D
N
D
GS
R
Q--EV
I
AEA
C
K
V
IL
K
E
KA
PDI
A
FSY
TTD
P
E
V
A
F
S
D
V
DFV
MAHI
RVG
K
Y
-
P
M
RELDE
K
IPLRHG
V
V
GQ
---
ET
C
GPGGI
AY
G
M
R
S
I
G
G
V
L
E
L
V
D
Y
ME
K
Y
S
PNAWMLNY
S
NPAA
I
V
A
EA
T
R
R
LR
P
NA
K
I
L
N
I
C
D
M
PIG
IESR
M
A
QI
V
G
L
Q
D
RKQ
M
R
V
R
YY
GLNH
F
GWWTS
IED
--LQ
G
N
--
D
L
M
H
Q
L
R
QY
V
S
KHGYVPPQQDTHTE
A
SWND
TY
AKA
RD
V
QAL
-----------
DP
D
TLP
N
T
YL
K
YY
L
F
P
D
Y
-
VVQH
S
NP
EH
TR
A
N---E
V
ME
HR
EKQ
V
F
D
-
--
-
-
----------
-
-
----
----
----
-
---
-
-
------
A
S
RA
I
T
A
A
G
N
SAAGKLEI
DE
H
A
SY
I
V
DLAAAIAFNTQERMLLI
VPN
N
G
A
I
H
N
F
D
DEAM
VE
I
P
C
L
VG
H
NG
--
P
E
P
LVVG
D
I
PQ
F
QK---
GLM
S
Q
QVA
VE
K
L
VV
D
A
W
E
QRSYQH
L
WQ
A
IT
LS
K
---
T
V
P
S
ASV
A
K
A
I
L
DEL
L
E
A
N
KA
YW
P
EL
fig|358709.5.peg.80
Escherichia coli 101-1 (3-439/440)
K
F
S
VV
V
A
GGGST
F
TP
GI
V
L
M
L
L
ANQDR
F
P
LRA
L
K
F
Y
D
N
D
GA
R
Q--EV
I
AEA
C
K
V
IL
K
E
KA
PDI
A
FSY
TTD
P
E
V
A
F
S
D
V
DFV
MAHI
RVG
K
Y
-
P
M
RELDE
K
IPLRHG
V
V
GQ
---
ET
C
GPGGI
AY
G
M
R
S
I
G
G
V
L
E
L
V
D
Y
ME
K
Y
S
PNAWMLNY
S
NPAA
I
V
A
EA
T
R
R
LR
P
NA
K
I
L
N
I
C
D
M
PIG
IESR
M
A
QI
V
G
L
Q
D
RKQ
M
R
V
R
YY
GLNH
F
GWWTS
IED
--LQ
G
N
--
D
L
M
P
Q
L
R
QY
V
S
KHGYVPPQQDTHTE
A
SWND
TY
AKA
RD
V
QAL
-----------
AP
D
TLP
N
T
YL
K
YY
L
F
P
D
Y
-
VVQH
S
NP
EH
TR
A
N---E
V
ME
HR
EKQ
V
F
D
-
--
-
-
----------
-
-
----
----
----
-
---
-
-
------
AC
RA
I
T
A
A
G
N
SAAGKLEI
DE
H
A
SY
I
V
DLAAAIAFNTQERMLLI
VPN
N
G
A
I
H
N
F
D
DEAM
VE
I
P
C
L
VG
H
NG
--
P
E
P
LVVG
D
I
PQ
F
QK---
GLM
S
Q
QVA
VE
K
L
VV
D
A
W
E
QRSYQH
L
WQ
A
IT
LS
K
---
T
V
P
S
ASV
A
K
A
I
L
DEL
L
E
A
N
KA
YW
P
EL
fig|413997.3.peg.3741
Escherichia coli B str. REL606 (3-439/440)
K
F
S
VV
V
A
GGGST
F
TP
GI
V
L
M
L
L
ANQDR
F
P
LRA
L
K
F
Y
D
N
D
GA
R
Q--EV
I
AEA
C
K
V
IL
K
E
KA
PDI
A
FSY
TTD
P
E
V
A
F
S
D
V
DFV
MAHI
RVG
K
Y
-
P
M
RELDE
K
IPLRHG
V
V
GQ
---
ET
C
GPGGI
AY
G
M
R
S
I
G
G
V
L
E
L
V
D
Y
ME
K
Y
S
PNAWMLNY
S
NPAA
I
V
A
EA
T
R
R
LR
P
NA
K
I
L
N
I
C
D
M
PIG
IESR
M
A
QI
V
G
L
Q
D
RKQ
M
R
V
R
YY
GLNH
F
GWWTS
IED
--LQ
G
N
--
D
L
M
P
Q
L
R
QY
V
S
KHGYVPPQQDTHTE
A
SWND
TY
AKA
RD
V
QAL
-----------
AP
D
TLP
N
T
YL
K
YY
L
F
P
D
Y
-
VVQH
S
NP
EH
TR
A
N---E
V
ME
HR
EKQ
V
F
D
-
--
-
-
----------
-
-
----
----
----
-
---
-
-
------
AC
RA
I
T
A
A
G
N
SAAGKLEI
DE
H
A
SY
I
V
DLAAAIAFNTQERMLLI
VPN
N
G
A
I
H
N
F
D
DEAM
VE
I
P
C
L
VG
H
NG
--
P
E
P
LVVG
D
I
PQ
F
QK---
GLM
S
Q
QVA
VE
K
L
VV
D
A
W
E
QRSYQH
L
WQ
A
IT
LS
K
---
T
V
P
S
ASV
A
K
A
I
L
DEL
L
E
A
N
KA
YW
P
EL
fig|550676.3.peg.3898
Escherichia coli B185 (3-439/440)
K
F
S
VV
V
A
GGGST
F
TP
GI
V
L
M
L
L
ANQDR
F
P
LRA
L
K
F
Y
D
N
D
GA
R
Q--EV
I
AEA
C
K
V
IL
K
E
KA
PDI
A
FSY
TTD
P
E
V
A
F
S
D
V
DFV
MAHI
RVG
K
Y
-
P
M
RELDE
K
IPLRHG
V
V
GQ
---
ET
C
GPGGI
AY
G
M
R
S
I
G
G
V
L
E
L
V
D
Y
ME
K
Y
S
PNAWMLNY
S
NPAA
I
V
A
EA
T
R
R
LR
P
NA
K
I
L
N
I
C
D
M
PIG
IESR
M
A
QI
V
G
L
Q
D
RKQ
M
R
V
R
YY
GLNH
F
GWWTS
IED
--LQ
G
N
--
D
L
M
P
Q
L
R
QY
V
S
KHGYVPPQQDTHTE
A
SWND
TY
AKA
RD
V
QAL
-----------
DP
D
TLP
N
T
YL
K
YY
L
F
P
D
Y
-
VVQH
S
NP
EH
TR
A
N---E
V
ME
HR
EKQ
V
F
D
-
--
-
-
----------
-
-
----
----
----
-
---
-
-
------
AC
RA
I
T
A
A
G
N
SAAGKLEI
DE
H
A
SY
I
V
DLAAAIAFNTQERMLLI
VPN
N
G
A
I
H
N
F
D
DEAM
VE
I
P
C
L
VG
H
NG
--
P
E
P
LVVG
D
I
PQ
F
QK---
GLM
S
Q
QVA
VE
K
L
VV
D
A
W
E
QRSYQH
L
WQ
A
IT
LS
K
---
T
V
P
S
ASV
A
K
A
I
L
DEL
L
E
A
N
KA
YW
P
EL
fig|511693.5.peg.3760
Escherichia coli BL21 (3-439/440)
K
F
S
VV
V
A
GGGST
F
TP
GI
V
L
M
L
L
ANQDR
F
P
LRA
L
K
F
Y
D
N
D
GA
R
Q--EV
I
AEA
C
K
V
IL
K
E
KA
PDI
A
FSY
TTD
P
E
V
A
F
S
D
V
DFV
MAHI
RVG
K
Y
-
P
M
RELDE
K
IPLRHG
V
V
GQ
---
ET
C
GPGGI
AY
G
M
R
S
I
G
G
V
L
E
L
V
D
Y
ME
K
Y
S
PNAWMLNY
S
NPAA
I
V
A
EA
T
R
R
LR
P
NA
K
I
L
N
I
C
D
M
PIG
IESR
M
A
QI
V
G
L
Q
D
RKQ
M
R
V
R
YY
GLNH
F
GWWTS
IED
--LQ
G
N
--
D
L
M
P
Q
L
R
QY
V
S
KHGYVPPQQDTHTE
A
SWND
TY
AKA
RD
V
QAL
-----------
AP
D
TLP
N
T
YL
K
YY
L
F
P
D
Y
-
VVQH
S
NP
EH
TR
A
N---E
V
ME
HR
EKQ
V
F
D
-
--
-
-
----------
-
-
----
----
----
-
---
-
-
------
AC
RA
I
T
A
A
G
N
SAAGKLEI
DE
H
A
SY
I
V
DLAAAIAFNTQERMLLI
VPN
N
G
A
I
H
N
F
D
DEAM
VE
I
P
C
L
VG
H
NG
--
P
E
P
LVVG
D
I
PQ
F
QK---
GLM
S
Q
QVA
VE
K
L
VV
D
A
W
E
QRSYQH
L
WQ
A
IT
LS
K
---
T
V
P
S
ASV
A
K
A
I
L
DEL
L
E
A
N
KA
YW
P
EL
fig|469008.4.peg.25
Escherichia coli BL21(DE3) (3-439/440)
K
F
S
VV
V
A
GGGST
F
TP
GI
V
L
M
L
L
ANQDR
F
P
LRA
L
K
F
Y
D
N
D
GA
R
Q--EV
I
AEA
C
K
V
IL
K
E
KA
PDI
A
FSY
TTD
P
E
V
A
F
S
D
V
DFV
MAHI
RVG
K
Y
-
P
M
RELDE
K
IPLRHG
V
V
GQ
---
ET
C
GPGGI
AY
G
M
R
S
I
G
G
V
L
E
L
V
D
Y
ME
K
Y
S
PNAWMLNY
S
NPAA
I
V
A
EA
T
R
R
LR
P
NA
K
I
L
N
I
C
D
M
PIG
IESR
M
A
QI
V
G
L
Q
D
RKQ
M
R
V
R
YY
GLNH
F
GWWTS
IED
--LQ
G
N
--
D
L
M
P
Q
L
R
QY
V
S
KHGYVPPQQDTHTE
A
SWND
TY
AKA
RD
V
QAL
-----------
AP
D
TLP
N
T
YL
K
YY
L
F
P
D
Y
-
VVQH
S
NP
EH
TR
A
N---E
V
ME
HR
EKQ
V
F
D
-
--
-
-
----------
-
-
----
----
----
-
---
-
-
------
AC
RA
I
T
A
A
G
N
SAAGKLEI
DE
H
A
SY
I
V
DLAAAIAFNTQERMLLI
VPN
N
G
A
I
H
N
F
D
DEAM
VE
I
P
C
L
VG
H
NG
--
P
E
P
LVVG
D
I
PQ
F
QK---
GLM
S
Q
QVA
VE
K
L
VV
D
A
W
E
QRSYQH
L
WQ
A
IT
LS
K
---
T
V
P
S
ASV
A
K
A
I
L
DEL
L
E
A
N
KA
YW
P
EL
fig|316401.4.peg.4508
Escherichia coli ETEC H10407 (3-439/440)
K
F
S
VV
V
A
GGGST
F
TP
GI
V
L
M
L
L
ANQDR
F
P
LRA
L
K
F
Y
D
N
D
GA
R
Q--EV
I
AEA
C
K
V
IL
K
E
KA
PDI
A
FSY
TTD
P
E
V
A
F
S
D
V
DFV
MAHI
RVG
K
Y
-
P
M
RELDE
K
IPLRHG
V
V
GQ
---
ET
C
GPGGI
AY
G
M
R
S
I
G
G
V
L
E
L
V
D
Y
ME
K
Y
S
PNAWMLNY
S
NPAA
I
V
A
EA
T
R
R
LR
P
NA
K
I
L
N
I
C
D
M
PIG
IESR
M
A
QI
V
G
L
Q
D
RKQ
M
R
V
R
YY
GLNH
F
GWWTS
IED
--LQ
G
N
--
D
L
M
P
Q
L
R
QY
V
S
KHGYVPPQQDTHTE
A
SWND
TY
AKA
RD
V
QAL
-----------
AP
D
TLP
N
T
YL
K
YY
L
F
P
D
Y
-
VVQH
S
NP
EH
TR
A
N---E
V
ME
HR
EKQ
V
F
D
-
--
-
-
----------
-
-
----
----
----
-
---
-
-
------
AC
RA
I
T
A
A
G
N
SAAGKLEI
DE
H
A
SY
I
V
DLAAAIAFNTQERMLLI
VPN
N
G
A
I
H
N
F
D
DEAM
VE
I
P
C
L
VG
H
NG
--
P
E
P
LVVG
D
I
PQ
F
QK---
GLM
S
Q
QVA
VE
K
L
VV
D
A
W
E
QRSYQH
L
WQ
A
IT
LS
K
---
T
V
P
S
ASV
A
K
A
I
L
DEL
L
E
A
N
KA
YW
P
EL
fig|749547.3.peg.4326
Escherichia coli MS 187-1 (3-439/440)
K
F
S
VV
V
A
GGGST
F
TP
GI
V
L
M
L
L
ANQDR
F
P
LRA
L
K
F
Y
D
N
D
GA
R
Q--EV
I
AEA
C
K
V
IL
K
E
KA
PDI
A
FSY
TTD
P
E
V
A
F
S
D
V
DFV
MAHI
RVG
K
Y
-
P
M
RELDE
K
IPLRHG
V
V
GQ
---
ET
C
GPGGI
AY
G
M
R
S
I
G
G
V
L
E
L
V
D
Y
ME
K
Y
S
PNAWMLNY
S
NPAA
I
V
A
EA
T
R
R
LR
P
NA
K
I
L
N
I
C
D
M
PIG
IESR
M
A
QI
V
G
L
Q
D
RKQ
M
R
V
R
YY
GLNH
F
GWWTS
IED
--LQ
G
N
--
D
L
M
P
Q
L
R
QY
V
S
KHGYVPPQQDTHTE
A
SWND
TY
AKA
RD
V
QAL
-----------
AP
D
TLP
N
T
YL
K
YY
L
F
P
D
Y
-
VVQH
S
NP
EH
TR
A
N---E
V
ME
HR
EKQ
V
F
D
-
--
-
-
----------
-
-
----
----
----
-
---
-
-
------
AC
RA
I
T
A
A
G
N
SAAGKLEI
DE
H
A
SY
I
V
DLAAAIAFNTQERMLLI
VPN
N
G
A
I
H
N
F
D
DEAM
VE
I
P
C
L
VG
H
NG
--
P
E
P
LVVG
D
I
PQ
F
QK---
GLM
S
Q
QVA
VE
K
L
VV
D
A
W
E
QRSYQH
L
WQ
A
IT
LS
K
---
T
V
P
S
ASV
A
K
A
I
L
DEL
L
E
A
N
KA
YW
P
EL
fig|749527.3.peg.5251
Escherichia coli MS 21-1 (3-439/440)
K
F
S
VV
V
A
GGGST
F
TP
GI
V
L
M
L
L
ANQDR
F
P
LRA
L
K
F
Y
D
N
D
GA
R
Q--EV
I
AEA
C
K
V
IL
K
E
KA
PDI
A
FSY
TTD
P
E
V
A
F
S
D
V
DFV
MAHI
RVG
K
Y
-
P
M
RELDE
K
IPLRHG
V
V
GQ
---
ET
C
GPGGI
AY
G
M
R
S
I
G
G
V
L
E
L
V
D
Y
ME
K
Y
S
PNAWMLNY
S
NPAA
I
V
A
EA
T
R
R
LR
P
NA
K
I
L
N
I
C
D
M
PIG
IESR
M
A
QI
V
G
L
Q
D
RKQ
M
R
V
R
YY
GLNH
F
GWWTS
IED
--LQ
G
N
--
D
L
M
P
Q
L
R
QY
V
S
KHGYVPPQQDTHTE
A
SWND
TY
AKA
RD
V
QAL
-----------
DP
D
TLP
N
T
YL
K
YY
L
F
P
D
Y
-
VVQH
S
NP
EH
TR
A
N---E
V
ME
HR
EKQ
V
F
D
-
--
-
-
----------
-
-
----
----
----
-
---
-
-
------
AC
RA
I
T
A
A
G
N
SAAGKLEI
DE
H
A
SY
I
V
DLAAAIAFNTQERMLLI
VPN
N
G
A
I
H
N
F
D
DEAM
VE
I
P
C
L
VG
H
NG
--
P
E
P
LVVG
D
I
PQ
F
QK---
GLM
S
Q
QVA
VE
K
L
VV
D
A
W
E
QRSYQH
L
WQ
A
IT
LS
K
---
T
V
P
S
ASV
A
K
A
I
L
DEL
L
E
A
N
KA
YW
P
EL
fig|637912.3.peg.2507
Escherichia coli OP50 (3-439/440)
K
F
S
VV
V
A
GGGST
F
TP
GI
V
L
M
L
L
ANQDR
F
P
LRA
L
K
F
Y
D
N
D
GA
R
Q--EV
I
AEA
C
K
V
IL
K
E
KA
PDI
A
FSY
TTD
P
E
V
A
F
S
D
V
DFV
MAHI
RVG
K
Y
-
P
M
RELDE
K
IPLRHG
V
V
GQ
---
ET
C
GPGGI
AY
G
M
R
S
I
G
G
V
L
E
L
V
D
Y
ME
K
Y
S
PNAWMLNY
S
NPAA
I
V
A
EA
T
R
R
LR
P
NA
K
I
L
N
I
C
D
M
PIG
IESR
M
A
QI
V
G
L
Q
D
RKQ
M
R
V
R
YY
GLNH
F
GWWTS
IED
--LQ
G
N
--
D
L
M
P
Q
L
R
QY
V
S
KHGYVPPQQDTHTE
A
SWND
TY
AKA
RD
V
QAL
-----------
AP
D
TLP
N
T
YL
K
YY
L
F
P
D
Y
-
VVQH
S
NP
EH
TR
A
N---E
V
ME
HR
EKQ
V
F
D
-
--
-
-
----------
-
-
----
----
----
-
---
-
-
------
AC
RA
I
T
A
A
G
N
SAAGKLEI
DE
H
A
SY
I
V
DLAAAIAFNTQERMLLI
VPN
N
G
A
I
H
N
F
D
DEAM
VE
I
P
C
L
VG
H
NG
--
P
E
P
LVVG
D
I
PQ
F
QK---
GLM
S
Q
QVA
VE
K
L
VV
D
A
W
E
QRSYQH
L
WQ
A
IT
LS
K
---
T
V
P
S
ASV
A
K
A
I
L
DEL
L
E
A
N
KA
YW
P
EL
fig|656444.3.peg.5022
Escherichia coli TA280 (3-439/440)
K
F
S
VV
V
A
GGGST
F
TP
GI
V
L
M
L
L
ANQDR
F
P
LRA
L
K
F
Y
D
N
D
GA
R
Q--EV
I
AEA
C
K
V
IL
K
E
KA
PDI
A
FSY
TTD
P
E
V
A
F
S
D
V
DFV
MAHI
RVG
K
Y
-
P
M
RELDE
K
IPLRHG
V
V
GQ
---
ET
C
GPGGI
AY
G
M
R
S
I
G
G
V
L
E
L
V
D
Y
ME
K
Y
S
PNAWMLNY
S
NPAA
I
V
A
EA
T
R
R
LR
P
NA
K
I
L
N
I
C
D
M
PIG
IESR
M
A
QI
V
G
L
Q
D
RKQ
M
R
V
R
YY
GLNH
F
GWWTS
IED
--LQ
G
N
--
D
L
M
P
Q
L
R
QY
V
S
KHGYVPPQQDTHTE
A
SWND
TY
AKA
RD
V
QAL
-----------
DP
D
TLP
N
T
YL
K
YY
L
F
P
D
Y
-
VVQH
S
NP
EH
TR
A
N---E
V
ME
HR
EKQ
V
F
D
-
--
-
-
----------
-
-
----
----
----
-
---
-
-
------
AC
RA
I
T
A
A
G
N
SAAGKLEI
DE
H
A
SY
I
V
DLAAAIAFNTQERMLLI
VPN
N
G
A
I
H
N
F
D
DEAM
VE
I
P
C
L
VG
H
NG
--
P
E
P
LVVG
D
I
PQ
F
QK---
GLM
S
Q
QVA
VE
K
L
VV
D
A
W
E
QRSYQH
L
WQ
A
IT
LS
K
---
T
V
P
S
ASV
A
K
A
I
L
DEL
L
E
A
N
KA
YW
P
EL
fig|749537.3.peg.1253
Escherichia coli MS 115-1 (3-439/440)
K
F
S
VV
V
A
GGGST
F
TP
GI
V
L
M
L
L
ANQDR
F
P
LRA
L
K
F
Y
D
N
D
GA
R
Q--EV
I
AEA
C
K
V
IL
K
E
KA
PDI
A
FSY
TTD
P
E
V
A
F
S
D
V
DFV
MAHI
RVG
K
Y
-
P
M
RELDE
K
IPLRHG
V
V
GQ
---
ET
C
GPGGI
AY
G
M
R
S
I
G
G
V
L
E
L
V
D
Y
ME
K
Y
S
PNAWMLNY
S
NPAA
I
V
A
EA
T
R
R
LR
P
NA
K
I
L
N
I
C
D
M
PIG
IESR
M
A
QI
V
G
L
Q
D
RKQ
M
R
V
R
YY
GLNH
F
GWWTS
IED
--LQ
G
N
--
D
L
M
P
Q
L
R
QY
V
S
KHGYVPPQQDTHTE
A
SWND
TY
AKA
RD
V
QAL
-----------
AP
D
TLP
N
T
YL
K
YY
L
F
P
D
Y
-
VVQH
S
NP
EH
TR
A
N---E
V
ME
HR
EKQ
V
F
D
-
--
-
-
----------
-
-
----
----
----
-
---
-
-
------
AC
RA
I
T
A
A
G
N
SAAGKLEI
DE
H
A
SY
I
V
DLAAAIAFNTQERMLLI
VPN
N
G
A
I
H
N
F
D
DEAM
VE
I
L
C
L
VG
H
NG
--
P
E
P
LVVG
D
I
PQ
F
QK---
GLM
S
Q
QVA
VE
K
L
VV
D
A
W
E
QRSYQH
L
WQ
A
IT
LS
K
---
T
V
P
S
ASV
A
K
A
I
L
DEL
L
E
A
N
KA
YW
P
EL
fig|562.371.peg.3044
Escherichia coli 1044A (3-439/440)
K
F
S
VV
V
A
GGGST
F
TP
GI
V
L
M
L
L
ANQDR
F
P
LRA
L
K
F
Y
D
N
D
GS
R
Q--EV
I
AEA
C
K
V
IL
K
E
KA
PDI
A
FSY
TTD
P
E
V
A
F
S
D
V
DFV
MAHI
RVG
K
Y
-
P
M
RELDE
K
IPLRHG
V
V
GQ
---
ET
C
GPGGI
AY
G
M
R
S
I
G
G
V
L
E
L
V
D
Y
ME
K
Y
S
PNAWMLNY
S
NPAA
I
V
A
EA
T
R
R
LR
P
NA
K
I
L
N
I
C
D
M
PIG
IESR
M
A
QI
V
G
L
Q
D
RKQ
M
R
V
R
YY
GLNH
F
GWWTS
IED
--LQ
G
N
--
D
L
M
H
Q
L
R
QY
V
S
KHGYVPPQQDTHTE
A
SWND
TY
AKA
RD
V
QAL
-----------
DP
D
TLP
N
T
YL
K
YY
L
F
P
D
Y
-
VVQH
S
NP
EH
TR
A
N---E
V
ME
HR
EKQ
V
F
D
-
--
-
-
----------
-
-
----
----
----
-
---
-
-
------
AC
RA
I
T
A
A
G
N
SAAGKLEI
DE
H
A
SY
I
V
DLAAAIAFNTQERMLLI
VPN
N
G
A
I
H
N
F
D
DEAM
VE
I
P
C
L
VG
H
NG
--
P
E
P
LVVG
D
I
PQ
F
QK---
GLM
S
Q
QVA
VE
K
L
VV
D
A
W
E
QRSYQH
L
WQ
A
IT
LS
K
---
T
V
P
S
ASV
A
K
A
I
L
DEL
L
E
A
N
KA
YW
P
EL
fig|562.373.peg.972
Escherichia coli 1125A (3-439/440)
K
F
S
VV
V
A
GGGST
F
TP
GI
V
L
M
L
L
ANQDR
F
P
LRA
L
K
F
Y
D
N
D
GS
R
Q--EV
I
AEA
C
K
V
IL
K
E
KA
PDI
A
FSY
TTD
P
E
V
A
F
S
D
V
DFV
MAHI
RVG
K
Y
-
P
M
RELDE
K
IPLRHG
V
V
GQ
---
ET
C
GPGGI
AY
G
M
R
S
I
G
G
V
L
E
L
V
D
Y
ME
K
Y
S
PNAWMLNY
S
NPAA
I
V
A
EA
T
R
R
LR
P
NA
K
I
L
N
I
C
D
M
PIG
IESR
M
A
QI
V
G
L
Q
D
RKQ
M
R
V
R
YY
GLNH
F
GWWTS
IED
--LQ
G
N
--
D
L
M
H
Q
L
R
QY
V
S
KHGYVPPQQDTHTE
A
SWND
TY
AKA
RD
V
QAL
-----------
DP
D
TLP
N
T
YL
K
YY
L
F
P
D
Y
-
VVQH
S
NP
EH
TR
A
N---E
V
ME
HR
EKQ
V
F
D
-
--
-
-
----------
-
-
----
----
----
-
---
-
-
------
AC
RA
I
T
A
A
G
N
SAAGKLEI
DE
H
A
SY
I
V
DLAAAIAFNTQERMLLI
VPN
N
G
A
I
H
N
F
D
DEAM
VE
I
P
C
L
VG
H
NG
--
P
E
P
LVVG
D
I
PQ
F
QK---
GLM
S
Q
QVA
VE
K
L
VV
D
A
W
E
QRSYQH
L
WQ
A
IT
LS
K
---
T
V
P
S
ASV
A
K
A
I
L
DEL
L
E
A
N
KA
YW
P
EL
fig|562.372.peg.3930
Escherichia coli 1212A (3-439/440)
K
F
S
VV
V
A
GGGST
F
TP
GI
V
L
M
L
L
ANQDR
F
P
LRA
L
K
F
Y
D
N
D
GS
R
Q--EV
I
AEA
C
K
V
IL
K
E
KA
PDI
A
FSY
TTD
P
E
V
A
F
S
D
V
DFV
MAHI
RVG
K
Y
-
P
M
RELDE
K
IPLRHG
V
V
GQ
---
ET
C
GPGGI
AY
G
M
R
S
I
G
G
V
L
E
L
V
D
Y
ME
K
Y
S
PNAWMLNY
S
NPAA
I
V
A
EA
T
R
R
LR
P
NA
K
I
L
N
I
C
D
M
PIG
IESR
M
A
QI
V
G
L
Q
D
RKQ
M
R
V
R
YY
GLNH
F
GWWTS
IED
--LQ
G
N
--
D
L
M
H
Q
L
R
QY
V
S
KHGYVPPQQDTHTE
A
SWND
TY
AKA
RD
V
QAL
-----------
DP
D
TLP
N
T
YL
K
YY
L
F
P
D
Y
-
VVQH
S
NP
EH
TR
A
N---E
V
ME
HR
EKQ
V
F
D
-
--
-
-
----------
-
-
----
----
----
-
---
-
-
------
AC
RA
I
T
A
A
G
N
SAAGKLEI
DE
H
A
SY
I
V
DLAAAIAFNTQERMLLI
VPN
N
G
A
I
H
N
F
D
DEAM
VE
I
P
C
L
VG
H
NG
--
P
E
P
LVVG
D
I
PQ
F
QK---
GLM
S
Q
QVA
VE
K
L
VV
D
A
W
E
QRSYQH
L
WQ
A
IT
LS
K
---
T
V
P
S
ASV
A
K
A
I
L
DEL
L
E
A
N
KA
YW
P
EL
fig|562.374.peg.2020
Escherichia coli 536A (3-439/440)
K
F
S
VV
V
A
GGGST
F
TP
GI
V
L
M
L
L
ANQDR
F
P
LRA
L
K
F
Y
D
N
D
GS
R
Q--EV
I
AEA
C
K
V
IL
K
E
KA
PDI
A
FSY
TTD
P
E
V
A
F
S
D
V
DFV
MAHI
RVG
K
Y
-
P
M
RELDE
K
IPLRHG
V
V
GQ
---
ET
C
GPGGI
AY
G
M
R
S
I
G
G
V
L
E
L
V
D
Y
ME
K
Y
S
PNAWMLNY
S
NPAA
I
V
A
EA
T
R
R
LR
P
NA
K
I
L
N
I
C
D
M
PIG
IESR
M
A
QI
V
G
L
Q
D
RKQ
M
R
V
R
YY
GLNH
F
GWWTS
IED
--LQ
G
N
--
D
L
M
H
Q
L
R
QY
V
S
KHGYVPPQQDTHTE
A
SWND
TY
AKA
RD
V
QAL
-----------
DP
D
TLP
N
T
YL
K
YY
L
F
P
D
Y
-
VVQH
S
NP
EH
TR
A
N---E
V
ME
HR
EKQ
V
F
D
-
--
-
-
----------
-
-
----
----
----
-
---
-
-
------
AC
RA
I
T
A
A
G
N
SAAGKLEI
DE
H
A
SY
I
V
DLAAAIAFNTQERMLLI
VPN
N
G
A
I
H
N
F
D
DEAM
VE
I
P
C
L
VG
H
NG
--
P
E
P
LVVG
D
I
PQ
F
QK---
GLM
S
Q
QVA
VE
K
L
VV
D
A
W
E
QRSYQH
L
WQ
A
IT
LS
K
---
T
V
P
S
ASV
A
K
A
I
L
DEL
L
E
A
N
KA
YW
P
EL
fig|155864.1.peg.4628
Escherichia coli O157:H7 EDL933 (3-439/440)
K
F
S
VV
V
A
GGGST
F
TP
GI
V
L
M
L
L
ANQDR
F
P
LRA
L
K
F
Y
D
N
D
GS
R
Q--EV
I
AEA
C
K
V
IL
K
E
KA
PDI
A
FSY
TTD
P
E
V
A
F
S
D
V
DFV
MAHI
RVG
K
Y
-
P
M
RELDE
K
IPLRHG
V
V
GQ
---
ET
C
GPGGI
AY
G
M
R
S
I
G
G
V
L
E
L
V
D
Y
ME
K
Y
S
PNAWMLNY
S
NPAA
I
V
A
EA
T
R
R
LR
P
NA
K
I
L
N
I
C
D
M
PIG
IESR
M
A
QI
V
G
L
Q
D
RKQ
M
R
V
R
YY
GLNH
F
GWWTS
IED
--LQ
G
N
--
D
L
M
H
Q
L
R
QY
V
S
KHGYVPPQQDTHTE
A
SWND
TY
AKA
RD
V
QAL
-----------
DP
D
TLP
N
T
YL
K
YY
L
F
P
D
Y
-
VVQH
S
NP
EH
TR
A
N---E
V
ME
HR
EKQ
V
F
D
-
--
-
-
----------
-
-
----
----
----
-
---
-
-
------
AC
RA
I
T
A
A
G
N
SAAGKLEI
DE
H
A
SY
I
V
DLAAAIAFNTQERMLLI
VPN
N
G
A
I
H
N
F
D
DEAM
VE
I
P
C
L
VG
H
NG
--
P
E
P
LVVG
D
I
PQ
F
QK---
GLM
S
Q
QVA
VE
K
L
VV
D
A
W
E
QRSYQH
L
WQ
A
IT
LS
K
---
T
V
P
S
ASV
A
K
A
I
L
DEL
L
E
A
N
KA
YW
P
EL
fig|155864.8.peg.4586
Escherichia coli O157:H7 EDL933 (3-439/440)
K
F
S
VV
V
A
GGGST
F
TP
GI
V
L
M
L
L
ANQDR
F
P
LRA
L
K
F
Y
D
N
D
GS
R
Q--EV
I
AEA
C
K
V
IL
K
E
KA
PDI
A
FSY
TTD
P
E
V
A
F
S
D
V
DFV
MAHI
RVG
K
Y
-
P
M
RELDE
K
IPLRHG
V
V
GQ
---
ET
C
GPGGI
AY
G
M
R
S
I
G
G
V
L
E
L
V
D
Y
ME
K
Y
S
PNAWMLNY
S
NPAA
I
V
A
EA
T
R
R
LR
P
NA
K
I
L
N
I
C
D
M
PIG
IESR
M
A
QI
V
G
L
Q
D
RKQ
M
R
V
R
YY
GLNH
F
GWWTS
IED
--LQ
G
N
--
D
L
M
H
Q
L
R
QY
V
S
KHGYVPPQQDTHTE
A
SWND
TY
AKA
RD
V
QAL
-----------
DP
D
TLP
N
T
YL
K
YY
L
F
P
D
Y
-
VVQH
S
NP
EH
TR
A
N---E
V
ME
HR
EKQ
V
F
D
-
--
-
-
----------
-
-
----
----
----
-
---
-
-
------
AC
RA
I
T
A
A
G
N
SAAGKLEI
DE
H
A
SY
I
V
DLAAAIAFNTQERMLLI
VPN
N
G
A
I
H
N
F
D
DEAM
VE
I
P
C
L
VG
H
NG
--
P
E
P
LVVG
D
I
PQ
F
QK---
GLM
S
Q
QVA
VE
K
L
VV
D
A
W
E
QRSYQH
L
WQ
A
IT
LS
K
---
T
V
P
S
ASV
A
K
A
I
L
DEL
L
E
A
N
KA
YW
P
EL
fig|444454.5.peg.3711
Escherichia coli O157:H7 str. EC4024 (3-439/440)
K
F
S
VV
V
A
GGGST
F
TP
GI
V
L
M
L
L
ANQDR
F
P
LRA
L
K
F
Y
D
N
D
GS
R
Q--EV
I
AEA
C
K
V
IL
K
E
KA
PDI
A
FSY
TTD
P
E
V
A
F
S
D
V
DFV
MAHI
RVG
K
Y
-
P
M
RELDE
K
IPLRHG
V
V
GQ
---
ET
C
GPGGI
AY
G
M
R
S
I
G
G
V
L
E
L
V
D
Y
ME
K
Y
S
PNAWMLNY
S
NPAA
I
V
A
EA
T
R
R
LR
P
NA
K
I
L
N
I
C
D
M
PIG
IESR
M
A
QI
V
G
L
Q
D
RKQ
M
R
V
R
YY
GLNH
F
GWWTS
IED
--LQ
G
N
--
D
L
M
H
Q
L
R
QY
V
S
KHGYVPPQQDTHTE
A
SWND
TY
AKA
RD
V
QAL
-----------
DP
D
TLP
N
T
YL
K
YY
L
F
P
D
Y
-
VVQH
S
NP
EH
TR
A
N---E
V
ME
HR
EKQ
V
F
D
-
--
-
-
----------
-
-
----
----
----
-
---
-
-
------
AC
RA
I
T
A
A
G
N
SAAGKLEI
DE
H
A
SY
I
V
DLAAAIAFNTQERMLLI
VPN
N
G
A
I
H
N
F
D
DEAM
VE
I
P
C
L
VG
H
NG
--
P
E
P
LVVG
D
I
PQ
F
QK---
GLM
S
Q
QVA
VE
K
L
VV
D
A
W
E
QRSYQH
L
WQ
A
IT
LS
K
---
T
V
P
S
ASV
A
K
A
I
L
DEL
L
E
A
N
KA
YW
P
EL
fig|444449.5.peg.3166
Escherichia coli O157:H7 str. EC4042 (3-439/440)
K
F
S
VV
V
A
GGGST
F
TP
GI
V
L
M
L
L
ANQDR
F
P
LRA
L
K
F
Y
D
N
D
GS
R
Q--EV
I
AEA
C
K
V
IL
K
E
KA
PDI
A
FSY
TTD
P
E
V
A
F
S
D
V
DFV
MAHI
RVG
K
Y
-
P
M
RELDE
K
IPLRHG
V
V
GQ
---
ET
C
GPGGI
AY
G
M
R
S
I
G
G
V
L
E
L
V
D
Y
ME
K
Y
S
PNAWMLNY
S
NPAA
I
V
A
EA
T
R
R
LR
P
NA
K
I
L
N
I
C
D
M
PIG
IESR
M
A
QI
V
G
L
Q
D
RKQ
M
R
V
R
YY
GLNH
F
GWWTS
IED
--LQ
G
N
--
D
L
M
H
Q
L
R
QY
V
S
KHGYVPPQQDTHTE
A
SWND
TY
AKA
RD
V
QAL
-----------
DP
D
TLP
N
T
YL
K
YY
L
F
P
D
Y
-
VVQH
S
NP
EH
TR
A
N---E
V
ME
HR
EKQ
V
F
D
-
--
-
-
----------
-
-
----
----
----
-
---
-
-
------
AC
RA
I
T
A
A
G
N
SAAGKLEI
DE
H
A
SY
I
V
DLAAAIAFNTQERMLLI
VPN
N
G
A
I
H
N
F
D
DEAM
VE
I
P
C
L
VG
H
NG
--
P
E
P
LVVG
D
I
PQ
F
QK---
GLM
S
Q
QVA
VE
K
L
VV
D
A
W
E
QRSYQH
L
WQ
A
IT
LS
K
---
T
V
P
S
ASV
A
K
A
I
L
DEL
L
E
A
N
KA
YW
P
EL
fig|444448.5.peg.1922
Escherichia coli O157:H7 str. EC4045 (3-439/440)
K
F
S
VV
V
A
GGGST
F
TP
GI
V
L
M
L
L
ANQDR
F
P
LRA
L
K
F
Y
D
N
D
GS
R
Q--EV
I
AEA
C
K
V
IL
K
E
KA
PDI
A
FSY
TTD
P
E
V
A
F
S
D
V
DFV
MAHI
RVG
K
Y
-
P
M
RELDE
K
IPLRHG
V
V
GQ
---
ET
C
GPGGI
AY
G
M
R
S
I
G
G
V
L
E
L
V
D
Y
ME
K
Y
S
PNAWMLNY
S
NPAA
I
V
A
EA
T
R
R
LR
P
NA
K
I
L
N
I
C
D
M
PIG
IESR
M
A
QI
V
G
L
Q
D
RKQ
M
R
V
R
YY
GLNH
F
GWWTS
IED
--LQ
G
N
--
D
L
M
H
Q
L
R
QY
V
S
KHGYVPPQQDTHTE
A
SWND
TY
AKA
RD
V
QAL
-----------
DP
D
TLP
N
T
YL
K
YY
L
F
P
D
Y
-
VVQH
S
NP
EH
TR
A
N---E
V
ME
HR
EKQ
V
F
D
-
--
-
-
----------
-
-
----
----
----
-
---
-
-
------
AC
RA
I
T
A
A
G
N
SAAGKLEI
DE
H
A
SY
I
V
DLAAAIAFNTQERMLLI
VPN
N
G
A
I
H
N
F
D
DEAM
VE
I
P
C
L
VG
H
NG
--
P
E
P
LVVG
D
I
PQ
F
QK---
GLM
S
Q
QVA
VE
K
L
VV
D
A
W
E
QRSYQH
L
WQ
A
IT
LS
K
---
T
V
P
S
ASV
A
K
A
I
L
DEL
L
E
A
N
KA
YW
P
EL
fig|444453.5.peg.1452
Escherichia coli O157:H7 str. EC4076 (3-439/440)
K
F
S
VV
V
A
GGGST
F
TP
GI
V
L
M
L
L
ANQDR
F
P
LRA
L
K
F
Y
D
N
D
GS
R
Q--EV
I
AEA
C
K
V
IL
K
E
KA
PDI
A
FSY
TTD
P
E
V
A
F
S
D
V
DFV
MAHI
RVG
K
Y
-
P
M
RELDE
K
IPLRHG
V
V
GQ
---
ET
C
GPGGI
AY
G
M
R
S
I
G
G
V
L
E
L
V
D
Y
ME
K
Y
S
PNAWMLNY
S
NPAA
I
V
A
EA
T
R
R
LR
P
NA
K
I
L
N
I
C
D
M
PIG
IESR
M
A
QI
V
G
L
Q
D
RKQ
M
R
V
R
YY
GLNH
F
GWWTS
IED
--LQ
G
N
--
D
L
M
H
Q
L
R
QY
V
S
KHGYVPPQQDTHTE
A
SWND
TY
AKA
RD
V
QAL
-----------
DP
D
TLP
N
T
YL
K
YY
L
F
P
D
Y
-
VVQH
S
NP
EH
TR
A
N---E
V
ME
HR
EKQ
V
F
D
-
--
-
-
----------
-
-
----
----
----
-
---
-
-
------
AC
RA
I
T
A
A
G
N
SAAGKLEI
DE
H
A
SY
I
V
DLAAAIAFNTQERMLLI
VPN
N
G
A
I
H
N
F
D
DEAM
VE
I
P
C
L
VG
H
NG
--
P
E
P
LVVG
D
I
PQ
F
QK---
GLM
S
Q
QVA
VE
K
L
VV
D
A
W
E
QRSYQH
L
WQ
A
IT
LS
K
---
T
V
P
S
ASV
A
K
A
I
L
DEL
L
E
A
N
KA
YW
P
EL
fig|444452.5.peg.1647
Escherichia coli O157:H7 str. EC4113 (3-439/440)
K
F
S
VV
V
A
GGGST
F
TP
GI
V
L
M
L
L
ANQDR
F
P
LRA
L
K
F
Y
D
N
D
GS
R
Q--EV
I
AEA
C
K
V
IL
K
E
KA
PDI
A
FSY
TTD
P
E
V
A
F
S
D
V
DFV
MAHI
RVG
K
Y
-
P
M
RELDE
K
IPLRHG
V
V
GQ
---
ET
C
GPGGI
AY
G
M
R
S
I
G
G
V
L
E
L
V
D
Y
ME
K
Y
S
PNAWMLNY
S
NPAA
I
V
A
EA
T
R
R
LR
P
NA
K
I
L
N
I
C
D
M
PIG
IESR
M
A
QI
V
G
L
Q
D
RKQ
M
R
V
R
YY
GLNH
F
GWWTS
IED
--LQ
G
N
--
D
L
M
H
Q
L
R
QY
V
S
KHGYVPPQQDTHTE
A
SWND
TY
AKA
RD
V
QAL
-----------
DP
D
TLP
N
T
YL
K
YY
L
F
P
D
Y
-
VVQH
S
NP
EH
TR
A
N---E
V
ME
HR
EKQ
V
F
D
-
--
-
-
----------
-
-
----
----
----
-
---
-
-
------
AC
RA
I
T
A
A
G
N
SAAGKLEI
DE
H
A
SY
I
V
DLAAAIAFNTQERMLLI
VPN
N
G
A
I
H
N
F
D
DEAM
VE
I
P
C
L
VG
H
NG
--
P
E
P
LVVG
D
I
PQ
F
QK---
GLM
S
Q
QVA
VE
K
L
VV
D
A
W
E
QRSYQH
L
WQ
A
IT
LS
K
---
T
V
P
S
ASV
A
K
A
I
L
DEL
L
E
A
N
KA
YW
P
EL
fig|444450.8.peg.5003
Escherichia coli O157:H7 str. EC4115 (3-439/440)
K
F
S
VV
V
A
GGGST
F
TP
GI
V
L
M
L
L
ANQDR
F
P
LRA
L
K
F
Y
D
N
D
GS
R
Q--EV
I
AEA
C
K
V
IL
K
E
KA
PDI
A
FSY
TTD
P
E
V
A
F
S
D
V
DFV
MAHI
RVG
K
Y
-
P
M
RELDE
K
IPLRHG
V
V
GQ
---
ET
C
GPGGI
AY
G
M
R
S
I
G
G
V
L
E
L
V
D
Y
ME
K
Y
S
PNAWMLNY
S
NPAA
I
V
A
EA
T
R
R
LR
P
NA
K
I
L
N
I
C
D
M
PIG
IESR
M
A
QI
V
G
L
Q
D
RKQ
M
R
V
R
YY
GLNH
F
GWWTS
IED
--LQ
G
N
--
D
L
M
H
Q
L
R
QY
V
S
KHGYVPPQQDTHTE
A
SWND
TY
AKA
RD
V
QAL
-----------
DP
D
TLP
N
T
YL
K
YY
L
F
P
D
Y
-
VVQH
S
NP
EH
TR
A
N---E
V
ME
HR
EKQ
V
F
D
-
--
-
-
----------
-
-
----
----
----
-
---
-
-
------
AC
RA
I
T
A
A
G
N
SAAGKLEI
DE
H
A
SY
I
V
DLAAAIAFNTQERMLLI
VPN
N
G
A
I
H
N
F
D
DEAM
VE
I
P
C
L
VG
H
NG
--
P
E
P
LVVG
D
I
PQ
F
QK---
GLM
S
Q
QVA
VE
K
L
VV
D
A
W
E
QRSYQH
L
WQ
A
IT
LS
K
---
T
V
P
S
ASV
A
K
A
I
L
DEL
L
E
A
N
KA
YW
P
EL
fig|444451.5.peg.63
Escherichia coli O157:H7 str. EC4196 (3-439/440)
K
F
S
VV
V
A
GGGST
F
TP
GI
V
L
M
L
L
ANQDR
F
P
LRA
L
K
F
Y
D
N
D
GS
R
Q--EV
I
AEA
C
K
V
IL
K
E
KA
PDI
A
FSY
TTD
P
E
V
A
F
S
D
V
DFV
MAHI
RVG
K
Y
-
P
M
RELDE
K
IPLRHG
V
V
GQ
---
ET
C
GPGGI
AY
G
M
R
S
I
G
G
V
L
E
L
V
D
Y
ME
K
Y
S
PNAWMLNY
S
NPAA
I
V
A
EA
T
R
R
LR
P
NA
K
I
L
N
I
C
D
M
PIG
IESR
M
A
QI
V
G
L
Q
D
RKQ
M
R
V
R
YY
GLNH
F
GWWTS
IED
--LQ
G
N
--
D
L
M
H
Q
L
R
QY
V
S
KHGYVPPQQDTHTE
A
SWND
TY
AKA
RD
V
QAL
-----------
DP
D
TLP
N
T
YL
K
YY
L
F
P
D
Y
-
VVQH
S
NP
EH
TR
A
N---E
V
ME
HR
EKQ
V
F
D
-
--
-
-
----------
-
-
----
----
----
-
---
-
-
------
AC
RA
I
T
A
A
G
N
SAAGKLEI
DE
H
A
SY
I
V
DLAAAIAFNTQERMLLI
VPN
N
G
A
I
H
N
F
D
DEAM
VE
I
P
C
L
VG
H
NG
--
P
E
P
LVVG
D
I
PQ
F
QK---
GLM
S
Q
QVA
VE
K
L
VV
D
A
W
E
QRSYQH
L
WQ
A
IT
LS
K
---
T
V
P
S
ASV
A
K
A
I
L
DEL
L
E
A
N
KA
YW
P
EL
fig|444447.5.peg.2085
Escherichia coli O157:H7 str. EC4206 (3-439/440)
K
F
S
VV
V
A
GGGST
F
TP
GI
V
L
M
L
L
ANQDR
F
P
LRA
L
K
F
Y
D
N
D
GS
R
Q--EV
I
AEA
C
K
V
IL
K
E
KA
PDI
A
FSY
TTD
P
E
V
A
F
S
D
V
DFV
MAHI
RVG
K
Y
-
P
M
RELDE
K
IPLRHG
V
V
GQ
---
ET
C
GPGGI
AY
G
M
R
S
I
G
G
V
L
E
L
V
D
Y
ME
K
Y
S
PNAWMLNY
S
NPAA
I
V
A
EA
T
R
R
LR
P
NA
K
I
L
N
I
C
D
M
PIG
IESR
M
A
QI
V
G
L
Q
D
RKQ
M
R
V
R
YY
GLNH
F
GWWTS
IED
--LQ
G
N
--
D
L
M
H
Q
L
R
QY
V
S
KHGYVPPQQDTHTE
A
SWND
TY
AKA
RD
V
QAL
-----------
DP
D
TLP
N
T
YL
K
YY
L
F
P
D
Y
-
VVQH
S
NP
EH
TR
A
N---E
V
ME
HR
EKQ
V
F
D
-
--
-
-
----------
-
-
----
----
----
-
---
-
-
------
AC
RA
I
T
A
A
G
N
SAAGKLEI
DE
H
A
SY
I
V
DLAAAIAFNTQERMLLI
VPN
N
G
A
I
H
N
F
D
DEAM
VE
I
P
C
L
VG
H
NG
--
P
E
P
LVVG
D
I
PQ
F
QK---
GLM
S
Q
QVA
VE
K
L
VV
D
A
W
E
QRSYQH
L
WQ
A
IT
LS
K
---
T
V
P
S
ASV
A
K
A
I
L
DEL
L
E
A
N
KA
YW
P
EL
fig|478004.5.peg.478
Escherichia coli O157:H7 str. EC4401 (3-439/440)
K
F
S
VV
V
A
GGGST
F
TP
GI
V
L
M
L
L
ANQDR
F
P
LRA
L
K
F
Y
D
N
D
GS
R
Q--EV
I
AEA
C
K
V
IL
K
E
KA
PDI
A
FSY
TTD
P
E
V
A
F
S
D
V
DFV
MAHI
RVG
K
Y
-
P
M
RELDE
K
IPLRHG
V
V
GQ
---
ET
C
GPGGI
AY
G
M
R
S
I
G
G
V
L
E
L
V
D
Y
ME
K
Y
S
PNAWMLNY
S
NPAA
I
V
A
EA
T
R
R
LR
P
NA
K
I
L
N
I
C
D
M
PIG
IESR
M
A
QI
V
G
L
Q
D
RKQ
M
R
V
R
YY
GLNH
F
GWWTS
IED
--LQ
G
N
--
D
L
M
H
Q
L
R
QY
V
S
KHGYVPPQQDTHTE
A
SWND
TY
AKA
RD
V
QAL
-----------
DP
D
TLP
N
T
YL
K
YY
L
F
P
D
Y
-
VVQH
S
NP
EH
TR
A
N---E
V
ME
HR
EKQ
V
F
D
-
--
-
-
----------
-
-
----
----
----
-
---
-
-
------
AC
RA
I
T
A
A
G
N
SAAGKLEI
DE
H
A
SY
I
V
DLAAAIAFNTQERMLLI
VPN
N
G
A
I
H
N
F
D
DEAM
VE
I
P
C
L
VG
H
NG
--
P
E
P
LVVG
D
I
PQ
F
QK---
GLM
S
Q
QVA
VE
K
L
VV
D
A
W
E
QRSYQH
L
WQ
A
IT
LS
K
---
T
V
P
S
ASV
A
K
A
I
L
DEL
L
E
A
N
KA
YW
P
EL
fig|478005.5.peg.413
Escherichia coli O157:H7 str. EC4486 (3-439/440)
K
F
S
VV
V
A
GGGST
F
TP
GI
V
L
M
L
L
ANQDR
F
P
LRA
L
K
F
Y
D
N
D
GS
R
Q--EV
I
AEA
C
K
V
IL
K
E
KA
PDI
A
FSY
TTD
P
E
V
A
F
S
D
V
DFV
MAHI
RVG
K
Y
-
P
M
RELDE
K
IPLRHG
V
V
GQ
---
ET
C
GPGGI
AY
G
M
R
S
I
G
G
V
L
E
L
V
D
Y
ME
K
Y
S
PNAWMLNY
S
NPAA
I
V
A
EA
T
R
R
LR
P
NA
K
I
L
N
I
C
D
M
PIG
IESR
M
A
QI
V
G
L
Q
D
RKQ
M
R
V
R
YY
GLNH
F
GWWTS
IED
--LQ
G
N
--
D
L
M
H
Q
L
R
QY
V
S
KHGYVPPQQDTHTE
A
SWND
TY
AKA
RD
V
QAL
-----------
DP
D
TLP
N
T
YL
K
YY
L
F
P
D
Y
-
VVQH
S
NP
EH
TR
A
N---E
V
ME
HR
EKQ
V
F
D
-
--
-
-
----------
-
-
----
----
----
-
---
-
-
------
AC
RA
I
T
A
A
G
N
SAAGKLEI
DE
H
A
SY
I
V
DLAAAIAFNTQERMLLI
VPN
N
G
A
I
H
N
F
D
DEAM
VE
I
P
C
L
VG
H
NG
--
P
E
P
LVVG
D
I
PQ
F
QK---
GLM
S
Q
QVA
VE
K
L
VV
D
A
W
E
QRSYQH
L
WQ
A
IT
LS
K
---
T
V
P
S
ASV
A
K
A
I
L
DEL
L
E
A
N
KA
YW
P
EL
fig|478006.5.peg.463
Escherichia coli O157:H7 str. EC4501 (3-439/440)
K
F
S
VV
V
A
GGGST
F
TP
GI
V
L
M
L
L
ANQDR
F
P
LRA
L
K
F
Y
D
N
D
GS
R
Q--EV
I
AEA
C
K
V
IL
K
E
KA
PDI
A
FSY
TTD
P
E
V
A
F
S
D
V
DFV
MAHI
RVG
K
Y
-
P
M
RELDE
K
IPLRHG
V
V
GQ
---
ET
C
GPGGI
AY
G
M
R
S
I
G
G
V
L
E
L
V
D
Y
ME
K
Y
S
PNAWMLNY
S
NPAA
I
V
A
EA
T
R
R
LR
P
NA
K
I
L
N
I
C
D
M
PIG
IESR
M
A
QI
V
G
L
Q
D
RKQ
M
R
V
R
YY
GLNH
F
GWWTS
IED
--LQ
G
N
--
D
L
M
H
Q
L
R
QY
V
S
KHGYVPPQQDTHTE
A
SWND
TY
AKA
RD
V
QAL
-----------
DP
D
TLP
N
T
YL
K
YY
L
F
P
D
Y
-
VVQH
S
NP
EH
TR
A
N---E
V
ME
HR
EKQ
V
F
D
-
--
-
-
----------
-
-
----
----
----
-
---
-
-
------
AC
RA
I
T
A
A
G
N
SAAGKLEI
DE
H
A
SY
I
V
DLAAAIAFNTQERMLLI
VPN
N
G
A
I
H
N
F
D
DEAM
VE
I
P
C
L
VG
H
NG
--
P
E
P
LVVG
D
I
PQ
F
QK---
GLM
S
Q
QVA
VE
K
L
VV
D
A
W
E
QRSYQH
L
WQ
A
IT
LS
K
---
T
V
P
S
ASV
A
K
A
I
L
DEL
L
E
A
N
KA
YW
P
EL
fig|478007.5.peg.1522
Escherichia coli O157:H7 str. EC508 (3-439/440)
K
F
S
VV
V
A
GGGST
F
TP
GI
V
L
M
L
L
ANQDR
F
P
LRA
L
K
F
Y
D
N
D
GS
R
Q--EV
I
AEA
C
K
V
IL
K
E
KA
PDI
A
FSY
TTD
P
E
V
A
F
S
D
V
DFV
MAHI
RVG
K
Y
-
P
M
RELDE
K
IPLRHG
V
V
GQ
---
ET
C
GPGGI
AY
G
M
R
S
I
G
G
V
L
E
L
V
D
Y
ME
K
Y
S
PNAWMLNY
S
NPAA
I
V
A
EA
T
R
R
LR
P
NA
K
I
L
N
I
C
D
M
PIG
IESR
M
A
QI
V
G
L
Q
D
RKQ
M
R
V
R
YY
GLNH
F
GWWTS
IED
--LQ
G
N
--
D
L
M
H
Q
L
R
QY
V
S
KHGYVPPQQDTHTE
A
SWND
TY
AKA
RD
V
QAL
-----------
DP
D
TLP
N
T
YL
K
YY
L
F
P
D
Y
-
VVQH
S
NP
EH
TR
A
N---E
V
ME
HR
EKQ
V
F
D
-
--
-
-
----------
-
-
----
----
----
-
---
-
-
------
AC
RA
I
T
A
A
G
N
SAAGKLEI
DE
H
A
SY
I
V
DLAAAIAFNTQERMLLI
VPN
N
G
A
I
H
N
F
D
DEAM
VE
I
P
C
L
VG
H
NG
--
P
E
P
LVVG
D
I
PQ
F
QK---
GLM
S
Q
QVA
VE
K
L
VV
D
A
W
E
QRSYQH
L
WQ
A
IT
LS
K
---
T
V
P
S
ASV
A
K
A
I
L
DEL
L
E
A
N
KA
YW
P
EL
fig|478008.5.peg.985
Escherichia coli O157:H7 str. EC869 (3-439/440)
K
F
S
VV
V
A
GGGST
F
TP
GI
V
L
M
L
L
ANQDR
F
P
LRA
L
K
F
Y
D
N
D
GS
R
Q--EV
I
AEA
C
K
V
IL
K
E
KA
PDI
A
FSY
TTD
P
E
V
A
F
S
D
V
DFV
MAHI
RVG
K
Y
-
P
M
RELDE
K
IPLRHG
V
V
GQ
---
ET
C
GPGGI
AY
G
M
R
S
I
G
G
V
L
E
L
V
D
Y
ME
K
Y
S
PNAWMLNY
S
NPAA
I
V
A
EA
T
R
R
LR
P
NA
K
I
L
N
I
C
D
M
PIG
IESR
M
A
QI
V
G
L
Q
D
RKQ
M
R
V
R
YY
GLNH
F
GWWTS
IED
--LQ
G
N
--
D
L
M
H
Q
L
R
QY
V
S
KHGYVPPQQDTHTE
A
SWND
TY
AKA
RD
V
QAL
-----------
DP
D
TLP
N
T
YL
K
YY
L
F
P
D
Y
-
VVQH
S
NP
EH
TR
A
N---E
V
ME
HR
EKQ
V
F
D
-
--
-
-
----------
-
-
----
----
----
-
---
-
-
------
AC
RA
I
T
A
A
G
N
SAAGKLEI
DE
H
A
SY
I
V
DLAAAIAFNTQERMLLI
VPN
N
G
A
I
H
N
F
D
DEAM
VE
I
P
C
L
VG
H
NG
--
P
E
P
LVVG
D
I
PQ
F
QK---
GLM
S
Q
QVA
VE
K
L
VV
D
A
W
E
QRSYQH
L
WQ
A
IT
LS
K
---
T
V
P
S
ASV
A
K
A
I
L
DEL
L
E
A
N
KA
YW
P
EL
fig|637388.3.peg.2941
Escherichia coli O157:H7 str. FRIK2000 (3-439/440)
K
F
S
VV
V
A
GGGST
F
TP
GI
V
L
M
L
L
ANQDR
F
P
LRA
L
K
F
Y
D
N
D
GS
R
Q--EV
I
AEA
C
K
V
IL
K
E
KA
PDI
A
FSY
TTD
P
E
V
A
F
S
D
V
DFV
MAHI
RVG
K
Y
-
P
M
RELDE
K
IPLRHG
V
V
GQ
---
ET
C
GPGGI
AY
G
M
R
S
I
G
G
V
L
E
L
V
D
Y
ME
K
Y
S
PNAWMLNY
S
NPAA
I
V
A
EA
T
R
R
LR
P
NA
K
I
L
N
I
C
D
M
PIG
IESR
M
A
QI
V
G
L
Q
D
RKQ
M
R
V
R
YY
GLNH
F
GWWTS
IED
--LQ
G
N
--
D
L
M
H
Q
L
R
QY
V
S
KHGYVPPQQDTHTE
A
SWND
TY
AKA
RD
V
QAL
-----------
DP
D
TLP
N
T
YL
K
YY
L
F
P
D
Y
-
VVQH
S
NP
EH
TR
A
N---E
V
ME
HR
EKQ
V
F
D
-
--
-
-
----------
-
-
----
----
----
-
---
-
-
------
AC
RA
I
T
A
A
G
N
SAAGKLEI
DE
H
A
SY
I
V
DLAAAIAFNTQERMLLI
VPN
N
G
A
I
H
N
F
D
DEAM
VE
I
P
C
L
VG
H
NG
--
P
E
P
LVVG
D
I
PQ
F
QK---
GLM
S
Q
QVA
VE
K
L
VV
D
A
W
E
QRSYQH
L
WQ
A
IT
LS
K
---
T
V
P
S
ASV
A
K
A
I
L
DEL
L
E
A
N
KA
YW
P
EL
fig|570506.3.peg.4734
Escherichia coli O157:H7 str. FRIK966 (3-439/440)
K
F
S
VV
V
A
GGGST
F
TP
GI
V
L
M
L
L
ANQDR
F
P
LRA
L
K
F
Y
D
N
D
GS
R
Q--EV
I
AEA
C
K
V
IL
K
E
KA
PDI
A
FSY
TTD
P
E
V
A
F
S
D
V
DFV
MAHI
RVG
K
Y
-
P
M
RELDE
K
IPLRHG
V
V
GQ
---
ET
C
GPGGI
AY
G
M
R
S
I
G
G
V
L
E
L
V
D
Y
ME
K
Y
S
PNAWMLNY
S
NPAA
I
V
A
EA
T
R
R
LR
P
NA
K
I
L
N
I
C
D
M
PIG
IESR
M
A
QI
V
G
L
Q
D
RKQ
M
R
V
R
YY
GLNH
F
GWWTS
IED
--LQ
G
N
--
D
L
M
H
Q
L
R
QY
V
S
KHGYVPPQQDTHTE
A
SWND
TY
AKA
RD
V
QAL
-----------
DP
D
TLP
N
T
YL
K
YY
L
F
P
D
Y
-
VVQH
S
NP
EH
TR
A
N---E
V
ME
HR
EKQ
V
F
D
-
--
-
-
----------
-
-
----
----
----
-
---
-
-
------
AC
RA
I
T
A
A
G
N
SAAGKLEI
DE
H
A
SY
I
V
DLAAAIAFNTQERMLLI
VPN
N
G
A
I
H
N
F
D
DEAM
VE
I
P
C
L
VG
H
NG
--
P
E
P
LVVG
D
I
PQ
F
QK---
GLM
S
Q
QVA
VE
K
L
VV
D
A
W
E
QRSYQH
L
WQ
A
IT
LS
K
---
T
V
P
S
ASV
A
K
A
I
L
DEL
L
E
A
N
KA
YW
P
EL
fig|544404.4.peg.4814
Escherichia coli O157:H7 str. TW14359 (3-439/440)
K
F
S
VV
V
A
GGGST
F
TP
GI
V
L
M
L
L
ANQDR
F
P
LRA
L
K
F
Y
D
N
D
GS
R
Q--EV
I
AEA
C
K
V
IL
K
E
KA
PDI
A
FSY
TTD
P
E
V
A
F
S
D
V
DFV
MAHI
RVG
K
Y
-
P
M
RELDE
K
IPLRHG
V
V
GQ
---
ET
C
GPGGI
AY
G
M
R
S
I
G
G
V
L
E
L
V
D
Y
ME
K
Y
S
PNAWMLNY
S
NPAA
I
V
A
EA
T
R
R
LR
P
NA
K
I
L
N
I
C
D
M
PIG
IESR
M
A
QI
V
G
L
Q
D
RKQ
M
R
V
R
YY
GLNH
F
GWWTS
IED
--LQ
G
N
--
D
L
M
H
Q
L
R
QY
V
S
KHGYVPPQQDTHTE
A
SWND
TY
AKA
RD
V
QAL
-----------
DP
D
TLP
N
T
YL
K
YY
L
F
P
D
Y
-
VVQH
S
NP
EH
TR
A
N---E
V
ME
HR
EKQ
V
F
D
-
--
-
-
----------
-
-
----
----
----
-
---
-
-
------
AC
RA
I
T
A
A
G
N
SAAGKLEI
DE
H
A
SY
I
V
DLAAAIAFNTQERMLLI
VPN
N
G
A
I
H
N
F
D
DEAM
VE
I
P
C
L
VG
H
NG
--
P
E
P
LVVG
D
I
PQ
F
QK---
GLM
S
Q
QVA
VE
K
L
VV
D
A
W
E
QRSYQH
L
WQ
A
IT
LS
K
---
T
V
P
S
ASV
A
K
A
I
L
DEL
L
E
A
N
KA
YW
P
EL
fig|502346.5.peg.1993
Escherichia coli O157:H7 str. TW14588 (3-439/440)
K
F
S
VV
V
A
GGGST
F
TP
GI
V
L
M
L
L
ANQDR
F
P
LRA
L
K
F
Y
D
N
D
GS
R
Q--EV
I
AEA
C
K
V
IL
K
E
KA
PDI
A
FSY
TTD
P
E
V
A
F
S
D
V
DFV
MAHI
RVG
K
Y
-
P
M
RELDE
K
IPLRHG
V
V
GQ
---
ET
C
GPGGI
AY
G
M
R
S
I
G
G
V
L
E
L
V
D
Y
ME
K
Y
S
PNAWMLNY
S
NPAA
I
V
A
EA
T
R
R
LR
P
NA
K
I
L
N
I
C
D
M
PIG
IESR
M
A
QI
V
G
L
Q
D
RKQ
M
R
V
R
YY
GLNH
F
GWWTS
IED
--LQ
G
N
--
D
L
M
H
Q
L
R
QY
V
S
KHGYVPPQQDTHTE
A
SWND
TY
AKA
RD
V
QAL
-----------
DP
D
TLP
N
T
YL
K
YY
L
F
P
D
Y
-
VVQH
S
NP
EH
TR
A
N---E
V
ME
HR
EKQ
V
F
D
-
--
-
-
----------
-
-
----
----
----
-
---
-
-
------
AC
RA
I
T
A
A
G
N
SAAGKLEI
DE
H
A
SY
I
V
DLAAAIAFNTQERMLLI
VPN
N
G
A
I
H
N
F
D
DEAM
VE
I
P
C
L
VG
H
NG
--
P
E
P
LVVG
D
I
PQ
F
QK---
GLM
S
Q
QVA
VE
K
L
VV
D
A
W
E
QRSYQH
L
WQ
A
IT
LS
K
---
T
V
P
S
ASV
A
K
A
I
L
DEL
L
E
A
N
KA
YW
P
EL
fig|701177.3.peg.4497
Escherichia coli O55:H7 str. CB9615 (3-439/440)
K
F
S
VV
V
A
GGGST
F
TP
GI
V
L
M
L
L
ANQDR
F
P
LRA
L
K
F
Y
D
N
D
GS
R
Q--EV
I
AEA
C
K
V
IL
K
E
KA
PDI
A
FSY
TTD
P
E
V
A
F
S
D
V
DFV
MAHI
RVG
K
Y
-
P
M
RELDE
K
IPLRHG
V
V
GQ
---
ET
C
GPGGI
AY
G
M
R
S
I
G
G
V
L
E
L
V
D
Y
ME
K
Y
S
PNAWMLNY
S
NPAA
I
V
A
EA
T
R
R
LR
P
NA
K
I
L
N
I
C
D
M
PIG
IESR
M
A
QI
V
G
L
Q
D
RKQ
M
R
V
R
YY
GLNH
F
GWWTS
IED
--LQ
G
N
--
D
L
M
H
Q
L
R
QY
V
S
KHGYVPPQQDTHTE
A
SWND
TY
AKA
RD
V
QAL
-----------
DP
D
TLP
N
T
YL
K
YY
L
F
P
D
Y
-
VVQH
S
NP
EH
TR
A
N---E
V
ME
HR
EKQ
V
F
D
-
--
-
-
----------
-
-
----
----
----
-
---
-
-
------
AC
RA
I
T
A
A
G
N
SAAGKLEI
DE
H
A
SY
I
V
DLAAAIAFNTQERMLLI
VPN
N
G
A
I
H
N
F
D
DEAM
VE
I
P
C
L
VG
H
NG
--
P
E
P
LVVG
D
I
PQ
F
QK---
GLM
S
Q
QVA
VE
K
L
VV
D
A
W
E
QRSYQH
L
WQ
A
IT
LS
K
---
T
V
P
S
ASV
A
K
A
I
L
DEL
L
E
A
N
KA
YW
P
EL
fig|439855.10.peg.4188
Escherichia coli SMS-3-5 (3-439/440)
K
F
S
VV
V
A
GGGST
F
TP
GI
V
L
M
L
L
ANQDR
F
P
LRA
L
K
F
Y
D
N
D
GA
R
Q--EV
I
AEA
C
K
V
IL
K
E
KA
PDI
A
FSY
T
N
D
P
E
V
A
F
S
D
V
DFV
MAHI
RVG
K
Y
-
P
M
RELDE
K
IPLRHG
V
V
GQ
---
ET
C
GPGGI
AY
G
M
R
S
I
G
G
V
L
E
L
V
D
Y
ME
K
Y
S
PNAWMLNY
S
NPAA
I
V
A
EA
T
R
R
LR
P
NA
K
I
L
N
I
C
D
M
PIG
IESR
M
A
QI
V
G
L
Q
D
RKQ
M
R
V
R
YY
GLNH
F
GWWTS
IED
--LQ
G
N
--
D
L
M
P
Q
L
R
QY
V
S
KHGYVPPQQDTHTE
A
SWND
TY
AKA
RD
V
QAL
-----------
DP
D
TLP
N
T
YL
K
YY
L
F
P
D
Y
-
VVQH
S
NP
EH
TR
A
N---E
V
ME
HR
EKQ
V
F
D
-
--
-
-
----------
-
-
----
----
----
-
---
-
-
------
AC
RA
I
T
A
A
G
N
SAAGKLEI
DE
H
A
SY
I
V
DLAAAIAFNTQERMLLI
VPN
N
G
A
I
H
N
F
D
DEAM
VE
I
P
C
L
VG
H
NG
--
P
E
P
LVVG
E
I
PQ
F
QK---
GLM
S
Q
QVA
VE
K
L
VV
D
A
W
E
QRSYQH
L
WQ
A
IT
LS
K
---
T
V
P
S
AAV
A
K
A
I
L
DEL
L
E
A
N
KA
YW
P
EL
fig|670888.3.peg.2537
Escherichia coli 1827-70 (3-439/440)
K
F
S
VV
V
A
GGGST
F
TP
GI
V
L
M
L
L
ANQDR
F
P
LRA
L
K
F
Y
D
N
D
GA
R
Q--EV
I
AEA
C
K
V
IL
K
E
KA
PDI
A
FSY
TTD
P
E
V
A
F
S
D
V
DFV
MAHI
RVG
K
Y
-
P
M
RELDE
K
IPLRHG
V
V
GQ
---
ET
C
GPGGI
AY
G
M
R
S
I
G
G
V
L
E
L
V
D
Y
ME
K
Y
S
PNAWMLNY
S
NPAA
I
V
A
EA
T
R
R
LR
P
NA
K
I
L
N
I
C
D
M
PIG
IESR
M
A
QI
V
G
L
Q
D
RKQ
M
R
V
R
YY
GLNH
F
GWWTS
IED
--LQ
G
N
--
D
L
M
P
Q
L
R
QY
V
S
KHGYVPP
L
QDTHTE
A
SWND
TY
AKA
RD
V
QAL
-----------
DP
D
TLP
N
T
YL
K
YY
L
F
P
D
Y
-
VVQH
S
NP
EH
TR
A
N---E
V
ME
HR
EKQ
V
F
D
-
--
-
-
----------
-
-
----
----
----
-
---
-
-
------
AC
RA
I
T
A
A
G
N
SAAGKLEI
DE
H
A
SY
I
V
DLAAAIAFNTQERMLLI
VPN
N
G
A
I
H
N
F
D
DEAM
V
KI
P
C
L
VG
H
NG
--
P
E
P
LVVG
D
I
PQ
F
QK---
GLM
S
Q
QVA
VE
K
L
VV
D
A
W
E
QRSYQH
L
WQ
A
IT
LS
K
---
T
V
P
S
ASV
A
K
A
I
L
DEL
L
E
A
N
KA
YW
P
EL
fig|331112.3.peg.3648
Escherichia coli HS (3-439/440)
K
F
S
VV
V
A
GGGST
F
TP
GI
V
L
M
L
L
ANQDR
F
P
LRA
L
K
F
Y
D
N
D
GA
R
Q--EV
I
AEA
C
K
V
IL
K
E
KA
PDI
A
FSY
TTD
P
E
V
A
F
S
D
V
DFV
MAHI
RVG
K
Y
-
P
M
RELDE
K
IPLRHG
V
V
GQ
---
ET
C
GPGGI
AY
G
M
R
S
I
G
G
V
L
E
L
V
D
Y
ME
K
Y
S
PNAWMLNY
S
NPAA
I
V
A
EA
T
R
R
LR
P
NA
K
I
L
N
I
C
D
M
PIG
IESR
M
A
QI
V
G
L
Q
D
RKQ
M
R
V
R
YY
GLNH
F
GWWTS
IED
--LQ
G
N
--
D
L
M
P
Q
L
R
QY
V
S
KHGYVPP
L
QDTHTE
A
SWND
TY
AKA
RD
V
QAL
-----------
DP
D
TLP
N
T
YL
K
YY
L
F
P
D
Y
-
VVQH
S
NP
EH
TR
A
N---E
V
ME
HR
EKQ
V
F
D
-
--
-
-
----------
-
-
----
----
----
-
---
-
-
------
AC
RA
I
T
A
A
G
N
SAAGKLEI
DE
H
A
SY
I
V
DLAAAIAFNTQERMLLI
VPN
N
G
A
I
H
N
F
D
DEAM
V
KI
P
C
L
VG
H
NG
--
P
E
P
LVVG
D
I
PQ
F
QK---
GLM
S
Q
QVA
VE
K
L
VV
D
A
W
E
QRSYQH
L
WQ
A
IT
LS
K
---
T
V
P
S
ASV
A
K
A
I
L
DEL
L
E
A
N
KA
YW
P
EL
fig|331112.6.peg.3804
Escherichia coli HS (3-439/440)
K
F
S
VV
V
A
GGGST
F
TP
GI
V
L
M
L
L
ANQDR
F
P
LRA
L
K
F
Y
D
N
D
GA
R
Q--EV
I
AEA
C
K
V
IL
K
E
KA
PDI
A
FSY
TTD
P
E
V
A
F
S
D
V
DFV
MAHI
RVG
K
Y
-
P
M
RELDE
K
IPLRHG
V
V
GQ
---
ET
C
GPGGI
AY
G
M
R
S
I
G
G
V
L
E
L
V
D
Y
ME
K
Y
S
PNAWMLNY
S
NPAA
I
V
A
EA
T
R
R
LR
P
NA
K
I
L
N
I
C
D
M
PIG
IESR
M
A
QI
V
G
L
Q
D
RKQ
M
R
V
R
YY
GLNH
F
GWWTS
IED
--LQ
G
N
--
D
L
M
P
Q
L
R
QY
V
S
KHGYVPP
L
QDTHTE
A
SWND
TY
AKA
RD
V
QAL
-----------
DP
D
TLP
N
T
YL
K
YY
L
F
P
D
Y
-
VVQH
S
NP
EH
TR
A
N---E
V
ME
HR
EKQ
V
F
D
-
--
-
-
----------
-
-
----
----
----
-
---
-
-
------
AC
RA
I
T
A
A
G
N
SAAGKLEI
DE
H
A
SY
I
V
DLAAAIAFNTQERMLLI
VPN
N
G
A
I
H
N
F
D
DEAM
V
KI
P
C
L
VG
H
NG
--
P
E
P
LVVG
D
I
PQ
F
QK---
GLM
S
Q
QVA
VE
K
L
VV
D
A
W
E
QRSYQH
L
WQ
A
IT
LS
K
---
T
V
P
S
ASV
A
K
A
I
L
DEL
L
E
A
N
KA
YW
P
EL
fig|550677.3.peg.4269
Escherichia coli B354 (3-439/440)
K
F
S
VV
V
A
GGGST
F
TP
GI
V
L
M
L
L
ANQDR
F
P
LRA
L
K
F
Y
D
N
D
GA
R
Q--EV
I
AEA
C
K
V
IL
K
E
KA
PDI
A
FSY
TTD
P
E
V
A
F
S
D
V
DFV
MAHI
RVG
K
Y
-
P
M
RELDE
K
IPLRHG
V
V
GQ
---
ET
C
GPGGI
AY
G
M
R
S
I
G
G
V
L
E
L
V
D
Y
ME
K
Y
S
PNAWMLNY
S
NPAA
I
V
A
EA
T
R
R
LR
P
NA
K
I
L
N
I
C
D
M
PIG
IESR
M
A
QI
V
G
L
Q
D
RKQ
M
R
V
R
YY
GLNH
F
GWWTS
IED
--LQ
G
N
--
D
L
M
P
Q
L
R
QY
V
S
KHGYVPPQQDTHTE
A
SWND
TY
AKA
RD
V
QAL
-----------
DP
D
TLP
N
T
YL
K
YY
L
F
P
D
Y
-
VVQH
S
NP
EH
TR
A
N---E
V
ME
HR
EKQ
V
F
D
-
--
-
-
----------
-
-
----
----
----
-
---
-
-
------
AC
RA
I
T
A
A
G
N
SAAGKLEI
DE
H
A
SY
I
V
DLAAAIAFNTQERMLLI
VPN
N
G
A
I
H
N
F
D
DEAM
VE
I
P
C
L
VG
H
NG
--
P
E
P
LVVG
D
I
PQ
F
QK---
GLM
S
Q
QVA
VE
K
L
VV
D
A
W
E
QRSYQH
L
WQ
A
IT
LS
K
---
T
V
P
S
AAV
A
K
A
I
L
D
D
L
L
E
A
N
KA
YW
P
EL
fig|481805.6.peg.23
Escherichia coli ATCC 8739 (3-439/440)
K
F
S
G
V
V
A
GGGST
F
TP
GI
V
L
M
L
L
ANQDR
F
P
LRA
L
K
F
Y
D
N
D
GA
R
Q--EV
I
AEA
C
K
V
IL
K
E
KA
PDI
A
FSY
TTD
P
E
V
A
F
S
D
V
DFV
MAHI
RVG
K
Y
-
P
M
RELDE
K
IPLRHG
V
V
GQ
---
ET
C
GPGGI
AY
G
M
R
S
I
G
G
V
L
E
L
V
D
Y
ME
K
Y
S
PNAWMLNY
S
NPAA
I
V
A
EA
T
R
R
LR
P
NA
K
I
L
N
I
C
D
M
PIG
IESR
M
A
QI
V
G
L
Q
D
RKQ
M
R
V
R
YY
GLNH
F
GWWTS
IED
--LQ
G
N
--
D
L
M
P
Q
L
R
QY
V
S
KHGYVPPQQDTHTE
A
SWND
TY
AKA
RD
V
QAL
-----------
AP
D
TLP
N
T
YL
K
YY
L
F
P
D
Y
-
VVQH
S
NP
EH
TR
A
N---E
V
ME
HR
EKQ
V
F
D
-
--
-
-
----------
-
-
----
----
----
-
---
-
-
------
AC
RA
I
T
A
A
G
N
SAAGKLEI
DE
H
A
SY
I
V
DLAAAIAFNTQERMLLI
VPN
N
G
A
I
H
N
F
D
DEAM
VE
I
P
C
L
VG
H
NG
--
P
E
P
LVVG
D
I
PQ
F
QK---
GLM
S
Q
QVA
VE
K
L
VV
D
A
W
E
QRSYQH
L
WQ
A
IT
LS
K
---
T
V
P
S
ASV
A
K
A
I
L
DEL
L
E
A
N
KA
YW
P
EL
fig|656419.3.peg.4740
Escherichia coli M718 (3-439/440)
K
F
S
VV
V
A
GGGST
F
TP
GI
V
L
M
L
L
ANQDR
F
P
LRA
L
K
F
Y
D
N
D
GA
R
Q--EV
I
AEA
C
K
V
IL
K
E
KA
PDI
A
FSY
TTD
P
E
V
A
F
S
D
V
DFV
MAHI
RVG
K
Y
-
P
M
RELDE
K
IPLRHG
V
V
GQ
---
ET
C
GPGGI
AY
G
M
R
S
I
G
G
V
L
E
L
V
D
Y
ME
K
Y
S
PNAWMLNY
S
NPAA
I
V
A
EA
T
R
C
LR
P
NA
K
I
L
N
I
C
D
M
PIG
IESR
M
A
QI
V
G
L
Q
D
RKQ
M
R
V
R
YY
GLNH
F
GWWTS
IED
--LQ
G
N
--
D
L
M
P
Q
L
R
QY
V
S
KHGYVPPQQDTHTE
A
SWND
TY
AKA
RD
V
QAL
-----------
AP
D
TLP
N
T
YL
K
YY
L
F
P
D
Y
-
VVQH
S
NP
EH
TR
A
N---E
V
ME
HR
EKQ
V
F
D
-
--
-
-
----------
-
-
----
----
----
-
---
-
-
------
AC
RA
I
T
A
A
G
N
SAAGKLEI
DE
H
A
SY
I
V
DLAAAIAFNTQERMLLI
VPN
N
G
A
I
H
N
F
D
DEAM
VE
I
P
C
L
VG
H
NG
--
P
E
P
LVVG
D
I
PQ
F
QK---
GLM
S
Q
QVA
VE
K
L
VV
D
A
W
E
QRSYQH
L
WQ
A
IT
LS
K
---
T
V
P
S
ASV
A
K
A
I
L
DEL
L
E
A
N
KA
YW
P
EL
fig|749548.3.peg.13
Escherichia coli MS 196-1 (1-448/451)
M
MSA
P
K
IT
F
IG
A
GST
I
FV
KN
ILG
D
V
FHREA
L
K
TAH
I
A
L
M
D
I
D
PT
R
QEESH
I
--V
V
R
K
L
MD
S
AG
ASG
K
ITC
H
T
Q
Q
K
EAL
E
DADFV
VVAF
QI
G
G
Y
E
P
C
TVT
D
F
E
VCK
RHG
-
L
E
Q
TIAD
T
L
GPGGI
MR
A
LRTIP
H
L
W
QI
C
E
DM
T
E
V
CP
D
A
T
MLNY
V
NP
M
AM
N
T
W
A
M
Y
A
RY
P
HI
K
Q
V
GLCH
S
VQ
G
TAEE
L
A
RD
L
N
I
-
D
PAT
LR
Y
R
CA
G
I
NHM
AFYLE
L
E
R
KTAD
G
S
YV
N
L
Y
PELL
--
-
-
--------------
A
AYEA
GQA
PK
PN
I
HG-
-----------
--
NT
RC
Q
N
IV
R
Y
E
M
F
K
K
L
G
YFVT
E
SS
EH
F-
A
EYTPW
F
I
K
PG
RED
L
I
E
R
YK
V
P
LDEYPKRCVE
Q
L
ANWH
KELE
EYKK
A
SRI
D
I
KPSREY
A
S
TI
M
NAI
W
T
--------
G
E
P
S
VI
Y
G
N
----------------
V
R
N
D
G
L
IDN
L
P
QGCC
VE
V
A
C
L
V
D
A
NG
IQ
P
T
-
----
K
V
GT
L
PSHLA
A
LM
Q
T
NIN
V
Q
T
L
LT
E
A
I
L
TENRDR
V
YH
A
AM
MD
P
HTA
A
V
L
G
IDE
I
Y
AL
V
D
D
LI
A
AH
GD
WLP
GW
fig|749531.3.peg.2382
Escherichia coli MS 69-1 (1-448/451)
M
MSA
P
K
IT
F
IG
A
GST
I
FV
KN
ILG
D
V
FHREA
L
K
TAH
I
A
L
M
D
I
D
PT
R
LEESH
I
--V
V
R
K
L
MD
S
AG
ASG
K
ITC
H
T
Q
Q
K
EAL
Q
DADFV
VVAF
QI
G
G
Y
E
P
C
TVT
D
F
E
VCK
RHG
-
L
E
Q
TIAD
T
L
GPGGI
MR
A
LRTIP
H
L
W
QI
C
E
DM
T
E
V
CP
D
A
T
MLNY
V
NP
M
AM
N
T
W
A
M
Y
A
RY
P
HI
K
Q
V
GLCH
S
VQ
G
TAEE
L
A
RD
L
N
I
-
D
PAT
LR
Y
R
CA
G
I
NHM
AFYLE
L
E
R
KTAD
G
S
YV
N
L
Y
PELL
--
-
-
--------------
A
AYEA
GQA
PK
PN
I
HG-
-----------
--
NT
RC
Q
N
IV
R
Y
E
M
F
K
K
L
G
YFVT
E
SS
EH
F-
A
EYTPW
F
I
K
PG
RED
L
I
E
R
YK
V
P
LDEYPKRCVE
Q
L
ANWH
KELE
EYKN
A
SRI
D
I
KPSREY
A
S
TI
M
NAI
W
T
--------
G
E
P
S
VI
Y
G
N
----------------
V
R
N
E
G
L
IDN
L
P
QGCC
VE
V
A
C
L
V
D
A
NG
IQ
P
T
-
----
K
V
GT
L
PSHLA
A
LM
Q
T
NIN
V
Q
T
L
LT
E
A
I
L
TENRDR
V
YH
A
AM
MD
P
HTA
A
V
L
G
IDE
I
Y
AL
V
D
D
LI
A
AH
GD
WLP
GW
fig|525281.3.peg.1749
Escherichia coli 83972 (1-448/451)
M
MSA
P
K
IT
F
IG
A
GST
I
FV
KN
ILG
D
V
FHREA
L
K
TAH
I
A
L
M
D
I
D
PT
R
LEESH
I
--V
V
R
K
L
MD
S
AG
ASG
K
ITC
H
T
Q
Q
K
EAL
Q
DADFV
VVAF
QI
G
G
Y
E
P
C
TVT
D
F
E
VCK
RHG
-
L
E
Q
TIAD
T
L
GPGGI
MR
A
LRTIP
H
L
W
QI
C
E
DM
T
E
V
CP
D
A
T
MLNY
V
NP
M
AM
N
T
W
A
M
Y
A
RY
P
HI
K
Q
V
GLCH
S
VQ
G
TAEE
L
A
RD
L
N
I
-
D
PAT
LR
Y
R
CA
G
I
NHM
AFYLE
L
E
R
KTAD
G
S
YV
N
L
Y
PELL
--
-
-
--------------
A
AYEA
GQA
PK
PN
I
HG-
-----------
--
NT
RC
Q
N
IV
R
Y
E
M
F
K
K
L
G
YFVT
E
SS
EH
F-
A
EYTPW
F
I
K
PG
RED
L
I
E
R
YK
V
P
LDEYPKRCVE
Q
L
ANWH
KELE
EYKN
A
SRI
D
I
KPSREY
A
S
TI
M
NAI
W
T
--------
G
E
P
S
VI
Y
G
N
----------------
V
R
N
D
G
L
IDN
L
P
QGCC
VE
V
A
C
L
V
D
A
NG
IQ
P
T
-
----
K
V
GT
L
PSHLA
A
LM
Q
T
NIN
V
Q
T
L
LT
E
A
I
L
TENRDR
V
YH
A
AM
MD
P
HTA
A
V
L
G
IDE
I
Y
AL
V
D
D
LI
A
AH
GD
WLP
GW
fig|655817.3.peg.4868
Escherichia coli ABU 83972 (1-448/451)
M
MSA
P
K
IT
F
IG
A
GST
I
FV
KN
ILG
D
V
FHREA
L
K
TAH
I
A
L
M
D
I
D
PT
R
LEESH
I
--V
V
R
K
L
MD
S
AG
ASG
K
ITC
H
T
Q
Q
K
EAL
Q
DADFV
VVAF
QI
G
G
Y
E
P
C
TVT
D
F
E
VCK
RHG
-
L
E
Q
TIAD
T
L
GPGGI
MR
A
LRTIP
H
L
W
QI
C
E
DM
T
E
V
CP
D
A
T
MLNY
V
NP
M
AM
N
T
W
A
M
Y
A
RY
P
HI
K
Q
V
GLCH
S
VQ
G
TAEE
L
A
RD
L
N
I
-
D
PAT
LR
Y
R
CA
G
I
NHM
AFYLE
L
E
R
KTAD
G
S
YV
N
L
Y
PELL
--
-
-
--------------
A
AYEA
GQA
PK
PN
I
HG-
-----------
--
NT
RC
Q
N
IV
R
Y
E
M
F
K
K
L
G
YFVT
E
SS
EH
F-
A
EYTPW
F
I
K
PG
RED
L
I
E
R
YK
V
P
LDEYPKRCVE
Q
L
ANWH
KELE
EYKN
A
SRI
D
I
KPSREY
A
S
TI
M
NAI
W
T
--------
G
E
P
S
VI
Y
G
N
----------------
V
R
N
D
G
L
IDN
L
P
QGCC
VE
V
A
C
L
V
D
A
NG
IQ
P
T
-
----
K
V
GT
L
PSHLA
A
LM
Q
T
NIN
V
Q
T
L
LT
E
A
I
L
TENRDR
V
YH
A
AM
MD
P
HTA
A
V
L
G
IDE
I
Y
AL
V
D
D
LI
A
AH
GD
WLP
GW
fig|199310.1.peg.5017
Escherichia coli CFT073 (1-448/451)
M
MSA
P
K
IT
F
IG
A
GST
I
FV
KN
ILG
D
V
FHREA
L
K
TAH
I
A
L
M
D
I
D
PT
R
LEESH
I
--V
V
R
K
L
MD
S
AG
ASG
K
ITC
H
T
Q
Q
K
EAL
Q
DADFV
VVAF
QI
G
G
Y
E
P
C
TVT
D
F
E
VCK
RHG
-
L
E
Q
TIAD
T
L
GPGGI
MR
A
LRTIP
H
L
W
QI
C
E
DM
T
E
V
CP
D
A
T
MLNY
V
NP
M
AM
N
T
W
A
M
Y
A
RY
P
HI
K
Q
V
GLCH
S
VQ
G
TAEE
L
A
RD
L
N
I
-
D
PAT
LR
Y
R
CA
G
I
NHM
AFYLE
L
E
R
KTAD
G
S
YV
N
L
Y
PELL
--
-
-
--------------
A
AYEA
GQA
PK
PN
I
HG-
-----------
--
NT
RC
Q
N
IV
R
Y
E
M
F
K
K
L
G
YFVT
E
SS
EH
F-
A
EYTPW
F
I
K
PG
RED
L
I
E
R
YK
V
P
LDEYPKRCVE
Q
L
ANWH
KELE
EYKN
A
SRI
D
I
KPSREY
A
S
TI
M
NAI
W
T
--------
G
E
P
S
VI
Y
G
N
----------------
V
R
N
D
G
L
IDN
L
P
QGCC
VE
V
A
C
L
V
D
A
NG
IQ
P
T
-
----
K
V
GT
L
PSHLA
A
LM
Q
T
NIN
V
Q
T
L
LT
E
A
I
L
TENRDR
V
YH
A
AM
MD
P
HTA
A
V
L
G
IDE
I
Y
AL
V
D
D
LI
A
AH
GD
WLP
GW
fig|199310.4.peg.4810
Escherichia coli CFT073 (1-448/451)
M
MSA
P
K
IT
F
IG
A
GST
I
FV
KN
ILG
D
V
FHREA
L
K
TAH
I
A
L
M
D
I
D
PT
R
LEESH
I
--V
V
R
K
L
MD
S
AG
ASG
K
ITC
H
T
Q
Q
K
EAL
Q
DADFV
VVAF
QI
G
G
Y
E
P
C
TVT
D
F
E
VCK
RHG
-
L
E
Q
TIAD
T
L
GPGGI
MR
A
LRTIP
H
L
W
QI
C
E
DM
T
E
V
CP
D
A
T
MLNY
V
NP
M
AM
N
T
W
A
M
Y
A
RY
P
HI
K
Q
V
GLCH
S
VQ
G
TAEE
L
A
RD
L
N
I
-
D
PAT
LR
Y
R
CA
G
I
NHM
AFYLE
L
E
R
KTAD
G
S
YV
N
L
Y
PELL
--
-
-
--------------
A
AYEA
GQA
PK
PN
I
HG-
-----------
--
NT
RC
Q
N
IV
R
Y
E
M
F
K
K
L
G
YFVT
E
SS
EH
F-
A
EYTPW
F
I
K
PG
RED
L
I
E
R
YK
V
P
LDEYPKRCVE
Q
L
ANWH
KELE
EYKN
A
SRI
D
I
KPSREY
A
S
TI
M
NAI
W
T
--------
G
E
P
S
VI
Y
G
N
----------------
V
R
N
D
G
L
IDN
L
P
QGCC
VE
V
A
C
L
V
D
A
NG
IQ
P
T
-
----
K
V
GT
L
PSHLA
A
LM
Q
T
NIN
V
Q
T
L
LT
E
A
I
L
TENRDR
V
YH
A
AM
MD
P
HTA
A
V
L
G
IDE
I
Y
AL
V
D
D
LI
A
AH
GD
WLP
GW
fig|749546.3.peg.1611
Escherichia coli MS 185-1 (1-448/451)
M
MSA
P
K
IT
F
IG
A
GST
I
FV
KN
ILG
D
V
FHREA
L
K
TAH
I
A
L
M
D
I
D
PT
R
LEESH
I
--V
V
R
K
L
MD
S
AG
ASG
K
ITC
H
T
Q
Q
K
EAL
Q
DADFV
VVAF
QI
G
G
Y
E
P
C
TVT
D
F
E
VCK
RHG
-
L
E
Q
TIAD
T
L
GPGGI
MR
A
LRTIP
H
L
W
QI
C
E
DM
T
E
V
CP
D
A
T
MLNY
V
NP
M
AM
N
T
W
A
M
Y
A
RY
P
HI
K
Q
V
GLCH
S
VQ
G
TAEE
L
A
RD
L
N
I
-
D
PAT
LR
Y
R
CA
G
I
NHM
AFYLE
L
E
R
KTAD
G
S
YV
N
L
Y
PELL
--
-
-
--------------
A
AYEA
GQA
PK
PN
I
HG-
-----------
--
NT
RC
Q
N
IV
R
Y
E
M
F
K
K
L
G
YFVT
E
SS
EH
F-
A
EYTPW
F
I
K
PG
RED
L
I
E
R
YK
V
P
LDEYPKRCVE
Q
L
ANWH
KELE
EYKN
A
SRI
D
I
KPSREY
A
S
TI
M
NAI
W
T
--------
G
E
P
S
VI
Y
G
N
----------------
V
R
N
D
G
L
IDN
L
P
QGCC
VE
V
A
C
L
V
D
A
NG
IQ
P
T
-
----
K
V
GT
L
PSHLA
A
LM
Q
T
NIN
V
Q
T
L
LT
E
A
I
L
TENRDR
V
YH
A
AM
MD
P
HTA
A
V
L
G
IDE
I
Y
AL
V
D
D
LI
A
AH
GD
WLP
GW
fig|749528.3.peg.3738
Escherichia coli MS 45-1 (1-448/451)
M
MSA
P
K
IT
F
IG
A
GST
I
FV
KN
ILG
D
V
FHREA
L
K
TAH
I
A
L
M
D
I
D
PT
R
LEESH
I
--V
V
R
K
L
MD
S
AG
ASG
K
ITC
H
T
Q
Q
K
EAL
Q
DADFV
VVAF
QI
G
G
Y
E
P
C
TVT
D
F
E
VCK
RHG
-
L
E
Q
TIAD
T
L
GPGGI
MR
A
LRTIP
H
L
W
QI
C
E
DM
T
E
V
CP
D
A
T
MLNY
V
NP
M
AM
N
T
W
A
M
Y
A
RY
P
HI
K
Q
V
GLCH
S
VQ
G
TAEE
L
A
RD
L
N
I
-
D
PAT
LR
Y
R
CA
G
I
NHM
AFYLE
L
E
R
KTAD
G
S
YV
N
L
Y
PELL
--
-
-
--------------
A
AYEA
GQA
PK
PN
I
HG-
-----------
--
NT
RC
Q
N
IV
R
Y
E
M
F
K
K
L
G
YFVT
E
SS
EH
F-
A
EYTPW
F
I
K
PG
RED
L
I
E
R
YK
V
P
LDEYPKRCVE
Q
L
ANWH
KELE
EYKN
A
SRI
D
I
KPSREY
A
S
TI
M
NAI
W
T
--------
G
E
P
S
VI
Y
G
N
----------------
V
R
N
D
G
L
IDN
L
P
QGCC
VE
V
A
C
L
V
D
A
NG
IQ
P
T
-
----
K
V
GT
L
PSHLA
A
LM
Q
T
NIN
V
Q
T
L
LT
E
A
I
L
TENRDR
V
YH
A
AM
MD
P
HTA
A
V
L
G
IDE
I
Y
AL
V
D
D
LI
A
AH
GD
WLP
GW
fig|656437.3.peg.4629
Escherichia coli TA143 (1-448/451)
M
MSA
P
K
IT
F
IG
A
GST
I
FV
KN
ILG
D
V
FHREA
L
K
TAH
I
A
L
M
D
I
D
PT
R
LEESH
I
--V
V
R
K
L
MD
S
AG
ASG
K
ITC
H
T
Q
Q
K
EAL
Q
DADFV
VVAF
QI
G
G
Y
E
P
C
TVT
D
F
E
VCK
RHG
-
L
E
Q
TIAD
T
L
GPGGI
MR
A
LRTIP
H
L
W
QI
C
E
DM
T
E
V
CP
D
A
T
MLNY
V
NP
M
AM
N
T
W
A
M
Y
A
RY
P
HI
K
Q
V
GLCH
S
VQ
G
TAEE
L
A
RD
L
N
I
-
D
PAT
LR
Y
R
CA
G
I
NHM
AFYLE
L
E
R
KTAD
G
S
YV
N
L
Y
PELL
--
-
-
--------------
A
AYEA
GQA
PK
PN
I
HG-
-----------
--
NT
RC
Q
N
IV
R
Y
E
M
F
K
K
L
G
YFVT
E
SS
EH
F-
A
EYTPW
F
I
K
PG
RED
L
I
E
R
YK
V
P
LDEYPKRCVE
Q
L
ANWH
KELE
EYKN
A
SRI
D
I
KPSREY
A
S
TI
M
NAI
W
T
--------
G
E
P
S
VI
Y
G
N
----------------
V
R
N
D
G
L
IDN
L
P
QGCC
VE
V
A
C
L
V
D
A
NG
IQ
P
T
-
----
K
V
GT
L
PSHLA
A
LM
Q
T
NIN
V
Q
T
L
LT
E
A
I
L
TENRDR
V
YH
A
AM
MD
P
HTA
A
V
L
G
IDE
I
Y
AL
V
D
D
LI
A
AH
GD
WLP
GW
fig|550677.3.peg.115
Escherichia coli B354 (1-448/451)
M
MSA
P
K
IT
F
IG
A
GST
I
FV
KN
ILG
D
V
FHREA
L
K
TAH
I
A
L
M
D
I
D
PT
R
LEESH
I
--V
V
R
K
L
MD
S
AG
ASG
K
ITC
H
T
Q
Q
K
EAL
Q
DADFV
VVAF
QI
G
G
Y
E
P
C
TVT
D
F
E
VCK
RHG
-
L
E
Q
TIAD
T
L
GPGGI
MR
A
LRTIP
H
L
W
QI
C
E
DM
T
E
V
CP
D
A
T
MLNY
V
NP
M
AM
N
T
W
A
M
Y
A
RY
P
HI
K
Q
V
GLCH
S
VQ
G
TAEE
L
A
RD
L
N
I
-
D
PAT
LR
Y
R
CA
G
I
NHM
AFYLE
L
E
R
KTAD
G
S
YV
N
L
Y
PELL
--
-
-
--------------
A
AYEA
GQA
PK
PN
I
HG-
-----------
--
NT
RC
Q
N
IV
R
Y
E
M
F
K
K
L
G
YFVT
E
SS
EH
F-
A
EYTPW
F
I
K
PG
RED
L
I
E
R
YK
V
P
LDEYPKRCVE
Q
L
ANWH
KELE
EYKN
A
SRI
D
I
KPSREY
A
S
TI
M
NAI
W
T
--------
G
E
P
S
VI
Y
G
N
----------------
V
R
N
D
G
L
IDN
L
P
QGCC
VE
V
A
C
L
V
D
A
NG
IQ
P
T
-
----
K
V
GT
L
PSHLA
A
LM
Q
T
NIN
V
Q
T
L
LT
E
A
I
L
TENRDR
V
YH
A
AM
MD
P
HTA
A
V
L
G
IDE
I
Y
AL
V
D
D
LI
A
AH
GH
WLP
GW
fig|1040638.4.peg.1165
Escherichia coli O104:H4 str. LB226692 (6-448/451)
K
IT
F
IG
A
GST
I
FV
KN
ILG
D
V
FHREA
L
K
TAH
I
A
L
M
D
I
D
PT
R
LEESH
I
--V
V
R
K
L
MD
S
AG
ASG
K
ITC
H
T
Q
Q
K
EAL
Q
DADFV
VVAF
QI
G
G
Y
E
P
C
TVT
D
F
E
VCK
RHG
-
L
E
Q
TIAD
T
L
GPGGI
MR
A
LRTIP
H
L
W
QI
C
E
DM
T
E
V
CP
D
A
T
MLNY
V
NP
M
AM
N
T
W
A
M
Y
A
RY
P
HI
K
Q
V
GLCH
S
VQ
G
TAEE
L
A
RD
L
N
I
-
D
PAT
LR
Y
R
CA
G
I
NHM
AFYLE
L
E
R
KTAD
G
S
YV
N
L
Y
PELL
--
-
-
--------------
A
AYEA
GQA
PK
PN
I
HG-
-----------
--
NT
RC
Q
N
IV
R
Y
E
M
F
K
K
L
G
YFVT
E
SS
EH
F-
A
EYTPW
F
I
K
PG
RED
L
I
E
R
YK
V
P
LDEYPKRCVE
Q
L
ANWH
KELE
EYKN
A
SRI
D
I
KPSREY
A
S
TI
M
NAI
W
T
--------
G
E
P
S
VI
Y
G
N
----------------
V
R
N
D
G
L
IDN
L
P
QGCC
VE
V
A
C
L
V
D
A
NG
IQ
P
T
-
----
K
V
GT
L
PSHLA
A
LM
Q
T
NIN
V
Q
T
L
LT
E
A
I
L
TENRDR
V
YH
A
AM
MD
P
HTA
A
V
L
G
IDE
I
Y
AL
V
D
D
LI
A
AH
GD
WLP
GW
fig|6666666.5357.peg.3967
Escherichia coli TY-2482 (6-448/451)
K
IT
F
IG
A
GST
I
FV
KN
ILG
D
V
FHREA
L
K
TAH
I
A
L
M
D
I
D
PT
R
LEESH
I
--V
V
R
K
L
MD
S
AG
ASG
K
ITC
H
T
Q
Q
K
EAL
Q
DADFV
VVAF
QI
G
G
Y
E
P
C
TVT
D
F
E
VCK
RHG
-
L
E
Q
TIAD
T
L
GPGGI
MR
A
LRTIP
H
L
W
QI
C
E
DM
T
E
V
CP
D
A
T
MLNY
V
NP
M
AM
N
T
W
A
M
Y
A
RY
P
HI
K
Q
V
GLCH
S
VQ
G
TAEE
L
A
RD
L
N
I
-
D
PAT
LR
Y
R
CA
G
I
NHM
AFYLE
L
E
R
KTAD
G
S
YV
N
L
Y
PELL
--
-
-
--------------
A
AYEA
GQA
PK
PN
I
HG-
-----------
--
NT
RC
Q
N
IV
R
Y
E
M
F
K
K
L
G
YFVT
E
SS
EH
F-
A
EYTPW
F
I
K
PG
RED
L
I
E
R
YK
V
P
LDEYPKRCVE
Q
L
ANWH
KELE
EYKN
A
SRI
D
I
KPSREY
A
S
TI
M
NAI
W
T
--------
G
E
P
S
VI
Y
G
N
----------------
V
R
N
D
G
L
IDN
L
P
QGCC
VE
V
A
C
L
V
D
A
NG
IQ
P
T
-
----
K
V
GT
L
PSHLA
A
LM
Q
T
NIN
V
Q
T
L
LT
E
A
I
L
TENRDR
V
YH
A
AM
MD
P
HTA
A
V
L
G
IDE
I
Y
AL
V
D
D
LI
A
AH
GD
WLP
GW
fig|344610.3.peg.1396
Escherichia coli 53638 (6-448/451)
K
IT
F
IG
A
GST
I
FV
KN
ILG
D
V
FHREA
L
K
TAH
I
A
L
M
D
I
D
PT
R
LEESH
I
--V
V
R
K
L
MD
S
AG
ASG
K
ITC
H
T
Q
Q
K
EAL
Q
DADFV
VVAF
QI
G
G
Y
E
P
C
TVT
D
F
E
VCK
RHG
-
L
E
Q
TIAD
T
L
GPGGI
MR
A
LRTIP
H
L
W
QI
C
E
DM
T
E
V
CP
D
A
T
MLNY
V
NP
M
AM
N
T
W
A
M
Y
A
RY
P
HI
K
Q
V
GLCH
S
VQ
G
TAEE
L
A
RD
L
N
I
-
D
PAT
LR
Y
R
CA
G
I
NHM
AFYLE
L
E
R
KTAD
G
S
YV
N
L
Y
PELL
--
-
-
--------------
A
AYEA
GQA
PK
PN
I
HG-
-----------
--
NT
RC
Q
N
IV
R
Y
E
M
F
K
K
L
G
YFVT
E
SS
EH
F-
A
EYTPW
F
I
K
PG
RED
L
I
E
R
YK
V
P
LDEYPKRCVE
Q
L
ANWH
KELE
EYKN
A
SRI
D
I
KPSREY
A
S
TI
M
NAI
W
T
--------
G
E
P
S
VI
Y
G
N
----------------
V
R
N
D
G
L
IDN
L
P
QGCC
VE
V
A
C
L
V
D
A
NG
IQ
P
T
-
----
K
V
GT
L
PSHLA
A
LM
Q
T
NIN
V
Q
T
L
LT
E
A
I
L
TENRDR
V
YH
A
AM
MD
P
HTA
A
V
L
G
IDE
I
Y
AL
V
D
D
LI
A
AH
GD
WLP
GW
fig|344610.7.peg.2009
Escherichia coli 53638 (6-448/451)
K
IT
F
IG
A
GST
I
FV
KN
ILG
D
V
FHREA
L
K
TAH
I
A
L
M
D
I
D
PT
R
LEESH
I
--V
V
R
K
L
MD
S
AG
ASG
K
ITC
H
T
Q
Q
K
EAL
Q
DADFV
VVAF
QI
G
G
Y
E
P
C
TVT
D
F
E
VCK
RHG
-
L
E
Q
TIAD
T
L
GPGGI
MR
A
LRTIP
H
L
W
QI
C
E
DM
T
E
V
CP
D
A
T
MLNY
V
NP
M
AM
N
T
W
A
M
Y
A
RY
P
HI
K
Q
V
GLCH
S
VQ
G
TAEE
L
A
RD
L
N
I
-
D
PAT
LR
Y
R
CA
G
I
NHM
AFYLE
L
E
R
KTAD
G
S
YV
N
L
Y
PELL
--
-
-
--------------
A
AYEA
GQA
PK
PN
I
HG-
-----------
--
NT
RC
Q
N
IV
R
Y
E
M
F
K
K
L
G
YFVT
E
SS
EH
F-
A
EYTPW
F
I
K
PG
RED
L
I
E
R
YK
V
P
LDEYPKRCVE
Q
L
ANWH
KELE
EYKN
A
SRI
D
I
KPSREY
A
S
TI
M
NAI
W
T
--------
G
E
P
S
VI
Y
G
N
----------------
V
R
N
D
G
L
IDN
L
P
QGCC
VE
V
A
C
L
V
D
A
NG
IQ
P
T
-
----
K
V
GT
L
PSHLA
A
LM
Q
T
NIN
V
Q
T
L
LT
E
A
I
L
TENRDR
V
YH
A
AM
MD
P
HTA
A
V
L
G
IDE
I
Y
AL
V
D
D
LI
A
AH
GD
WLP
GW
fig|585055.6.peg.4635
Escherichia coli 55989 (6-448/451)
K
IT
F
IG
A
GST
I
FV
KN
ILG
D
V
FHREA
L
K
TAH
I
A
L
M
D
I
D
PT
R
LEESH
I
--V
V
R
K
L
MD
S
AG
ASG
K
ITC
H
T
Q
Q
K
EAL
Q
DADFV
VVAF
QI
G
G
Y
E
P
C
TVT
D
F
E
VCK
RHG
-
L
E
Q
TIAD
T
L
GPGGI
MR
A
LRTIP
H
L
W
QI
C
E
DM
T
E
V
CP
D
A
T
MLNY
V
NP
M
AM
N
T
W
A
M
Y
A
RY
P
HI
K
Q
V
GLCH
S
VQ
G
TAEE
L
A
RD
L
N
I
-
D
PAT
LR
Y
R
CA
G
I
NHM
AFYLE
L
E
R
KTAD
G
S
YV
N
L
Y
PELL
--
-
-
--------------
A
AYEA
GQA
PK
PN
I
HG-
-----------
--
NT
RC
Q
N
IV
R
Y
E
M
F
K
K
L
G
YFVT
E
SS
EH
F-
A
EYTPW
F
I
K
PG
RED
L
I
E
R
YK
V
P
LDEYPKRCVE
Q
L
ANWH
KELE
EYKN
A
SRI
D
I
KPSREY
A
S
TI
M
NAI
W
T
--------
G
E
P
S
VI
Y
G
N
----------------
V
R
N
D
G
L
IDN
L
P
QGCC
VE
V
A
C
L
V
D
A
NG
IQ
P
T
-
----
K
V
GT
L
PSHLA
A
LM
Q
T
NIN
V
Q
T
L
LT
E
A
I
L
TENRDR
V
YH
A
AM
MD
P
HTA
A
V
L
G
IDE
I
Y
AL
V
D
D
LI
A
AH
GD
WLP
GW
fig|585055.8.peg.4640
Escherichia coli 55989 (6-448/451)
K
IT
F
IG
A
GST
I
FV
KN
ILG
D
V
FHREA
L
K
TAH
I
A
L
M
D
I
D
PT
R
LEESH
I
--V
V
R
K
L
MD
S
AG
ASG
K
ITC
H
T
Q
Q
K
EAL
Q
DADFV
VVAF
QI
G
G
Y
E
P
C
TVT
D
F
E
VCK
RHG
-
L
E
Q
TIAD
T
L
GPGGI
MR
A
LRTIP
H
L
W
QI
C
E
DM
T
E
V
CP
D
A
T
MLNY
V
NP
M
AM
N
T
W
A
M
Y
A
RY
P
HI
K
Q
V
GLCH
S
VQ
G
TAEE
L
A
RD
L
N
I
-
D
PAT
LR
Y
R
CA
G
I
NHM
AFYLE
L
E
R
KTAD
G
S
YV
N
L
Y
PELL
--
-
-
--------------
A
AYEA
GQA
PK
PN
I
HG-
-----------
--
NT
RC
Q
N
IV
R
Y
E
M
F
K
K
L
G
YFVT
E
SS
EH
F-
A
EYTPW
F
I
K
PG
RED
L
I
E
R
YK
V
P
LDEYPKRCVE
Q
L
ANWH
KELE
EYKN
A
SRI
D
I
KPSREY
A
S
TI
M
NAI
W
T
--------
G
E
P
S
VI
Y
G
N
----------------
V
R
N
D
G
L
IDN
L
P
QGCC
VE
V
A
C
L
V
D
A
NG
IQ
P
T
-
----
K
V
GT
L
PSHLA
A
LM
Q
T
NIN
V
Q
T
L
LT
E
A
I
L
TENRDR
V
YH
A
AM
MD
P
HTA
A
V
L
G
IDE
I
Y
AL
V
D
D
LI
A
AH
GD
WLP
GW
fig|481805.3.peg.4197
Escherichia coli ATCC 8739 (6-448/451)
K
IT
F
IG
A
GST
I
FV
KN
ILG
D
V
FHREA
L
K
TAH
I
A
L
M
D
I
D
PT
R
LEESH
I
--V
V
R
K
L
MD
S
AG
ASG
K
ITC
H
T
Q
Q
K
EAL
Q
DADFV
VVAF
QI
G
G
Y
E
P
C
TVT
D
F
E
VCK
RHG
-
L
E
Q
TIAD
T
L
GPGGI
MR
A
LRTIP
H
L
W
QI
C
E
DM
T
E
V
CP
D
A
T
MLNY
V
NP
M
AM
N
T
W
A
M
Y
A
RY
P
HI
K
Q
V
GLCH
S
VQ
G
TAEE
L
A
RD
L
N
I
-
D
PAT
LR
Y
R
CA
G
I
NHM
AFYLE
L
E
R
KTAD
G
S
YV
N
L
Y
PELL
--
-
-
--------------
A
AYEA
GQA
PK
PN
I
HG-
-----------
--
NT
RC
Q
N
IV
R
Y
E
M
F
K
K
L
G
YFVT
E
SS
EH
F-
A
EYTPW
F
I
K
PG
RED
L
I
E
R
YK
V
P
LDEYPKRCVE
Q
L
ANWH
KELE
EYKN
A
SRI
D
I
KPSREY
A
S
TI
M
NAI
W
T
--------
G
E
P
S
VI
Y
G
N
----------------
V
R
N
D
G
L
IDN
L
P
QGCC
VE
V
A
C
L
V
D
A
NG
IQ
P
T
-
----
K
V
GT
L
PSHLA
A
LM
Q
T
NIN
V
Q
T
L
LT
E
A
I
L
TENRDR
V
YH
A
AM
MD
P
HTA
A
V
L
G
IDE
I
Y
AL
V
D
D
LI
A
AH
GD
WLP
GW
fig|481805.6.peg.4184
Escherichia coli ATCC 8739 (6-448/451)
K
IT
F
IG
A
GST
I
FV
KN
ILG
D
V
FHREA
L
K
TAH
I
A
L
M
D
I
D
PT
R
LEESH
I
--V
V
R
K
L
MD
S
AG
ASG
K
ITC
H
T
Q
Q
K
EAL
Q
DADFV
VVAF
QI
G
G
Y
E
P
C
TVT
D
F
E
VCK
RHG
-
L
E
Q
TIAD
T
L
GPGGI
MR
A
LRTIP
H
L
W
QI
C
E
DM
T
E
V
CP
D
A
T
MLNY
V
NP
M
AM
N
T
W
A
M
Y
A
RY
P
HI
K
Q
V
GLCH
S
VQ
G
TAEE
L
A
RD
L
N
I
-
D
PAT
LR
Y
R
CA
G
I
NHM
AFYLE
L
E
R
KTAD
G
S
YV
N
L
Y
PELL
--
-
-
--------------
A
AYEA
GQA
PK
PN
I
HG-
-----------
--
NT
RC
Q
N
IV
R
Y
E
M
F
K
K
L
G
YFVT
E
SS
EH
F-
A
EYTPW
F
I
K
PG
RED
L
I
E
R
YK
V
P
LDEYPKRCVE
Q
L
ANWH
KELE
EYKN
A
SRI
D
I
KPSREY
A
S
TI
M
NAI
W
T
--------
G
E
P
S
VI
Y
G
N
----------------
V
R
N
D
G
L
IDN
L
P
QGCC
VE
V
A
C
L
V
D
A
NG
IQ
P
T
-
----
K
V
GT
L
PSHLA
A
LM
Q
T
NIN
V
Q
T
L
LT
E
A
I
L
TENRDR
V
YH
A
AM
MD
P
HTA
A
V
L
G
IDE
I
Y
AL
V
D
D
LI
A
AH
GD
WLP
GW
fig|344601.3.peg.1152
Escherichia coli B171 (6-448/451)
K
IT
F
IG
A
GST
I
FV
KN
ILG
D
V
FHREA
L
K
TAH
I
A
L
M
D
I
D
PT
R
LEESH
I
--V
V
R
K
L
MD
S
AG
ASG
K
ITC
H
T
Q
Q
K
EAL
Q
DADFV
VVAF
QI
G
G
Y
E
P
C
TVT
D
F
E
VCK
RHG
-
L
E
Q
TIAD
T
L
GPGGI
MR
A
LRTIP
H
L
W
QI
C
E
DM
T
E
V
CP
D
A
T
MLNY
V
NP
M
AM
N
T
W
A
M
Y
A
RY
P
HI
K
Q
V
GLCH
S
VQ
G
TAEE
L
A
RD
L
N
I
-
D
PAT
LR
Y
R
CA
G
I
NHM
AFYLE
L
E
R
KTAD
G
S
YV
N
L
Y
PELL
--
-
-
--------------
A
AYEA
GQA
PK
PN
I
HG-
-----------
--
NT
RC
Q
N
IV
R
Y
E
M
F
K
K
L
G
YFVT
E
SS
EH
F-
A
EYTPW
F
I
K
PG
RED
L
I
E
R
YK
V
P
LDEYPKRCVE
Q
L
ANWH
KELE
EYKN
A
SRI
D
I
KPSREY
A
S
TI
M
NAI
W
T
--------
G
E
P
S
VI
Y
G
N
----------------
V
R
N
D
G
L
IDN
L
P
QGCC
VE
V
A
C
L
V
D
A
NG
IQ
P
T
-
----
K
V
GT
L
PSHLA
A
LM
Q
T
NIN
V
Q
T
L
LT
E
A
I
L
TENRDR
V
YH
A
AM
MD
P
HTA
A
V
L
G
IDE
I
Y
AL
V
D
D
LI
A
AH
GD
WLP
GW
fig|344601.5.peg.1216
Escherichia coli B171 (6-448/451)
K
IT
F
IG
A
GST
I
FV
KN
ILG
D
V
FHREA
L
K
TAH
I
A
L
M
D
I
D
PT
R
LEESH
I
--V
V
R
K
L
MD
S
AG
ASG
K
ITC
H
T
Q
Q
K
EAL
Q
DADFV
VVAF
QI
G
G
Y
E
P
C
TVT
D
F
E
VCK
RHG
-
L
E
Q
TIAD
T
L
GPGGI
MR
A
LRTIP
H
L
W
QI
C
E
DM
T
E
V
CP
D
A
T
MLNY
V
NP
M
AM
N
T
W
A
M
Y
A
RY
P
HI
K
Q
V
GLCH
S
VQ
G
TAEE
L
A
RD
L
N
I
-
D
PAT
LR
Y
R
CA
G
I
NHM
AFYLE
L
E
R
KTAD
G
S
YV
N
L
Y
PELL
--
-
-
--------------
A
AYEA
GQA
PK
PN
I
HG-
-----------
--
NT
RC
Q
N
IV
R
Y
E
M
F
K
K
L
G
YFVT
E
SS
EH
F-
A
EYTPW
F
I
K
PG
RED
L
I
E
R
YK
V
P
LDEYPKRCVE
Q
L
ANWH
KELE
EYKN
A
SRI
D
I
KPSREY
A
S
TI
M
NAI
W
T
--------
G
E
P
S
VI
Y
G
N
----------------
V
R
N
D
G
L
IDN
L
P
QGCC
VE
V
A
C
L
V
D
A
NG
IQ
P
T
-
----
K
V
GT
L
PSHLA
A
LM
Q
T
NIN
V
Q
T
L
LT
E
A
I
L
TENRDR
V
YH
A
AM
MD
P
HTA
A
V
L
G
IDE
I
Y
AL
V
D
D
LI
A
AH
GD
WLP
GW
fig|340185.3.peg.1412
Escherichia coli E22 (6-448/451)
K
IT
F
IG
A
GST
I
FV
KN
ILG
D
V
FHREA
L
K
TAH
I
A
L
M
D
I
D
PT
R
LEESH
I
--V
V
R
K
L
MD
S
AG
ASG
K
ITC
H
T
Q
Q
K
EAL
Q
DADFV
VVAF
QI
G
G
Y
E
P
C
TVT
D
F
E
VCK
RHG
-
L
E
Q
TIAD
T
L
GPGGI
MR
A
LRTIP
H
L
W
QI
C
E
DM
T
E
V
CP
D
A
T
MLNY
V
NP
M
AM
N
T
W
A
M
Y
A
RY
P
HI
K
Q
V
GLCH
S
VQ
G
TAEE
L
A
RD
L
N
I
-
D
PAT
LR
Y
R
CA
G
I
NHM
AFYLE
L
E
R
KTAD
G
S
YV
N
L
Y
PELL
--
-
-
--------------
A
AYEA
GQA
PK
PN
I
HG-
-----------
--
NT
RC
Q
N
IV
R
Y
E
M
F
K
K
L
G
YFVT
E
SS
EH
F-
A
EYTPW
F
I
K
PG
RED
L
I
E
R
YK
V
P
LDEYPKRCVE
Q
L
ANWH
KELE
EYKN
A
SRI
D
I
KPSREY
A
S
TI
M
NAI
W
T
--------
G
E
P
S
VI
Y
G
N
----------------
V
R
N
D
G
L
IDN
L
P
QGCC
VE
V
A
C
L
V
D
A
NG
IQ
P
T
-
----
K
V
GT
L
PSHLA
A
LM
Q
T
NIN
V
Q
T
L
LT
E
A
I
L
TENRDR
V
YH
A
AM
MD
P
HTA
A
V
L
G
IDE
I
Y
AL
V
D
D
LI
A
AH
GD
WLP
GW
fig|340185.4.peg.1495
Escherichia coli E22 (6-448/451)
K
IT
F
IG
A
GST
I
FV
KN
ILG
D
V
FHREA
L
K
TAH
I
A
L
M
D
I
D
PT
R
LEESH
I
--V
V
R
K
L
MD
S
AG
ASG
K
ITC
H
T
Q
Q
K
EAL
Q
DADFV
VVAF
QI
G
G
Y
E
P
C
TVT
D
F
E
VCK
RHG
-
L
E
Q
TIAD
T
L
GPGGI
MR
A
LRTIP
H
L
W
QI
C
E
DM
T
E
V
CP
D
A
T
MLNY
V
NP
M
AM
N
T
W
A
M
Y
A
RY
P
HI
K
Q
V
GLCH
S
VQ
G
TAEE
L
A
RD
L
N
I
-
D
PAT
LR
Y
R
CA
G
I
NHM
AFYLE
L
E
R
KTAD
G
S
YV
N
L
Y
PELL
--
-
-
--------------
A
AYEA
GQA
PK
PN
I
HG-
-----------
--
NT
RC
Q
N
IV
R
Y
E
M
F
K
K
L
G
YFVT
E
SS
EH
F-
A
EYTPW
F
I
K
PG
RED
L
I
E
R
YK
V
P
LDEYPKRCVE
Q
L
ANWH
KELE
EYKN
A
SRI
D
I
KPSREY
A
S
TI
M
NAI
W
T
--------
G
E
P
S
VI
Y
G
N
----------------
V
R
N
D
G
L
IDN
L
P
QGCC
VE
V
A
C
L
V
D
A
NG
IQ
P
T
-
----
K
V
GT
L
PSHLA
A
LM
Q
T
NIN
V
Q
T
L
LT
E
A
I
L
TENRDR
V
YH
A
AM
MD
P
HTA
A
V
L
G
IDE
I
Y
AL
V
D
D
LI
A
AH
GD
WLP
GW
fig|331111.12.peg.4881
Escherichia coli E24377A (6-448/451)
K
IT
F
IG
A
GST
I
FV
KN
ILG
D
V
FHREA
L
K
TAH
I
A
L
M
D
I
D
PT
R
LEESH
I
--V
V
R
K
L
MD
S
AG
ASG
K
ITC
H
T
Q
Q
K
EAL
Q
DADFV
VVAF
QI
G
G
Y
E
P
C
TVT
D
F
E
VCK
RHG
-
L
E
Q
TIAD
T
L
GPGGI
MR
A
LRTIP
H
L
W
QI
C
E
DM
T
E
V
CP
D
A
T
MLNY
V
NP
M
AM
N
T
W
A
M
Y
A
RY
P
HI
K
Q
V
GLCH
S
VQ
G
TAEE
L
A
RD
L
N
I
-
D
PAT
LR
Y
R
CA
G
I
NHM
AFYLE
L
E
R
KTAD
G
S
YV
N
L
Y
PELL
--
-
-
--------------
A
AYEA
GQA
PK
PN
I
HG-
-----------
--
NT
RC
Q
N
IV
R
Y
E
M
F
K
K
L
G
YFVT
E
SS
EH
F-
A
EYTPW
F
I
K
PG
RED
L
I
E
R
YK
V
P
LDEYPKRCVE
Q
L
ANWH
KELE
EYKN
A
SRI
D
I
KPSREY
A
S
TI
M
NAI
W
T
--------
G
E
P
S
VI
Y
G
N
----------------
V
R
N
D
G
L
IDN
L
P
QGCC
VE
V
A
C
L
V
D
A
NG
IQ
P
T
-
----
K
V
GT
L
PSHLA
A
LM
Q
T
NIN
V
Q
T
L
LT
E
A
I
L
TENRDR
V
YH
A
AM
MD
P
HTA
A
V
L
G
IDE
I
Y
AL
V
D
D
LI
A
AH
GD
WLP
GW
fig|331111.3.peg.2272
Escherichia coli E24377A (6-448/451)
K
IT
F
IG
A
GST
I
FV
KN
ILG
D
V
FHREA
L
K
TAH
I
A
L
M
D
I
D
PT
R
LEESH
I
--V
V
R
K
L
MD
S
AG
ASG
K
ITC
H
T
Q
Q
K
EAL
Q
DADFV
VVAF
QI
G
G
Y
E
P
C
TVT
D
F
E
VCK
RHG
-
L
E
Q
TIAD
T
L
GPGGI
MR
A
LRTIP
H
L
W
QI
C
E
DM
T
E
V
CP
D
A
T
MLNY
V
NP
M
AM
N
T
W
A
M
Y
A
RY
P
HI
K
Q
V
GLCH
S
VQ
G
TAEE
L
A
RD
L
N
I
-
D
PAT
LR
Y
R
CA
G
I
NHM
AFYLE
L
E
R
KTAD
G
S
YV
N
L
Y
PELL
--
-
-
--------------
A
AYEA
GQA
PK
PN
I
HG-
-----------
--
NT
RC
Q
N
IV
R
Y
E
M
F
K
K
L
G
YFVT
E
SS
EH
F-
A
EYTPW
F
I
K
PG
RED
L
I
E
R
YK
V
P
LDEYPKRCVE
Q
L
ANWH
KELE
EYKN
A
SRI
D
I
KPSREY
A
S
TI
M
NAI
W
T
--------
G
E
P
S
VI
Y
G
N
----------------
V
R
N
D
G
L
IDN
L
P
QGCC
VE
V
A
C
L
V
D
A
NG
IQ
P
T
-
----
K
V
GT
L
PSHLA
A
LM
Q
T
NIN
V
Q
T
L
LT
E
A
I
L
TENRDR
V
YH
A
AM
MD
P
HTA
A
V
L
G
IDE
I
Y
AL
V
D
D
LI
A
AH
GD
WLP
GW
fig|562.375.peg.2959
Escherichia coli EC4100B (6-448/451)
K
IT
F
IG
A
GST
I
FV
KN
ILG
D
V
FHREA
L
K
TAH
I
A
L
M
D
I
D
PT
R
LEESH
I
--V
V
R
K
L
MD
S
AG
ASG
K
ITC
H
T
Q
Q
K
EAL
Q
DADFV
VVAF
QI
G
G
Y
E
P
C
TVT
D
F
E
VCK
RHG
-
L
E
Q
TIAD
T
L
GPGGI
MR
A
LRTIP
H
L
W
QI
C
E
DM
T
E
V
CP
D
A
T
MLNY
V
NP
M
AM
N
T
W
A
M
Y
A
RY
P
HI
K
Q
V
GLCH
S
VQ
G
TAEE
L
A
RD
L
N
I
-
D
PAT
LR
Y
R
CA
G
I
NHM
AFYLE
L
E
R
KTAD
G
S
YV
N
L
Y
PELL
--
-
-
--------------
A
AYEA
GQA
PK
PN
I
HG-
-----------
--
NT
RC
Q
N
IV
R
Y
E
M
F
K
K
L
G
YFVT
E
SS
EH
F-
A
EYTPW
F
I
K
PG
RED
L
I
E
R
YK
V
P
LDEYPKRCVE
Q
L
ANWH
KELE
EYKN
A
SRI
D
I
KPSREY
A
S
TI
M
NAI
W
T
--------
G
E
P
S
VI
Y
G
N
----------------
V
R
N
D
G
L
IDN
L
P
QGCC
VE
V
A
C
L
V
D
A
NG
IQ
P
T
-
----
K
V
GT
L
PSHLA
A
LM
Q
T
NIN
V
Q
T
L
LT
E
A
I
L
TENRDR
V
YH
A
AM
MD
P
HTA
A
V
L
G
IDE
I
Y
AL
V
D
D
LI
A
AH
GD
WLP
GW
fig|656408.3.peg.4616
Escherichia coli H591 (6-448/451)
K
IT
F
IG
A
GST
I
FV
KN
ILG
D
V
FHREA
L
K
TAH
I
A
L
M
D
I
D
PT
R
LEESH
I
--V
V
R
K
L
MD
S
AG
ASG
K
ITC
H
T
Q
Q
K
EAL
Q
DADFV
VVAF
QI
G
G
Y
E
P
C
TVT
D
F
E
VCK
RHG
-
L
E
Q
TIAD
T
L
GPGGI
MR
A
LRTIP
H
L
W
QI
C
E
DM
T
E
V
CP
D
A
T
MLNY
V
NP
M
AM
N
T
W
A
M
Y
A
RY
P
HI
K
Q
V
GLCH
S
VQ
G
TAEE
L
A
RD
L
N
I
-
D
PAT
LR
Y
R
CA
G
I
NHM
AFYLE
L
E
R
KTAD
G
S
YV
N
L
Y
PELL
--
-
-
--------------
A
AYEA
GQA
PK
PN
I
HG-
-----------
--
NT
RC
Q
N
IV
R
Y
E
M
F
K
K
L
G
YFVT
E
SS
EH
F-
A
EYTPW
F
I
K
PG
RED
L
I
E
R
YK
V
P
LDEYPKRCVE
Q
L
ANWH
KELE
EYKN
A
SRI
D
I
KPSREY
A
S
TI
M
NAI
W
T
--------
G
E
P
S
VI
Y
G
N
----------------
V
R
N
D
G
L
IDN
L
P
QGCC
VE
V
A
C
L
V
D
A
NG
IQ
P
T
-
----
K
V
GT
L
PSHLA
A
LM
Q
T
NIN
V
Q
T
L
LT
E
A
I
L
TENRDR
V
YH
A
AM
MD
P
HTA
A
V
L
G
IDE
I
Y
AL
V
D
D
LI
A
AH
GD
WLP
GW
fig|679206.4.peg.979
Escherichia coli MS 119-7 (6-448/451)
K
IT
F
IG
A
GST
I
FV
KN
ILG
D
V
FHREA
L
K
TAH
I
A
L
M
D
I
D
PT
R
LEESH
I
--V
V
R
K
L
MD
S
AG
ASG
K
ITC
H
T
Q
Q
K
EAL
Q
DADFV
VVAF
QI
G
G
Y
E
P
C
TVT
D
F
E
VCK
RHG
-
L
E
Q
TIAD
T
L
GPGGI
MR
A
LRTIP
H
L
W
QI
C
E
DM
T
E
V
CP
D
A
T
MLNY
V
NP
M
AM
N
T
W
A
M
Y
A
RY
P
HI
K
Q
V
GLCH
S
VQ
G
TAEE
L
A
RD
L
N
I
-
D
PAT
LR
Y
R
CA
G
I
NHM
AFYLE
L
E
R
KTAD
G
S
YV
N
L
Y
PELL
--
-
-
--------------
A
AYEA
GQA
PK
PN
I
HG-
-----------
--
NT
RC
Q
N
IV
R
Y
E
M
F
K
K
L
G
YFVT
E
SS
EH
F-
A
EYTPW
F
I
K
PG
RED
L
I
E
R
YK
V
P
LDEYPKRCVE
Q
L
ANWH
KELE
EYKN
A
SRI
D
I
KPSREY
A
S
TI
M
NAI
W
T
--------
G
E
P
S
VI
Y
G
N
----------------
V
R
N
D
G
L
IDN
L
P
QGCC
VE
V
A
C
L
V
D
A
NG
IQ
P
T
-
----
K
V
GT
L
PSHLA
A
LM
Q
T
NIN
V
Q
T
L
LT
E
A
I
L
TENRDR
V
YH
A
AM
MD
P
HTA
A
V
L
G
IDE
I
Y
AL
V
D
D
LI
A
AH
GD
WLP
GW
fig|679205.4.peg.4495
Escherichia coli MS 124-1 (6-448/451)
K
IT
F
IG
A
GST
I
FV
KN
ILG
D
V
FHREA
L
K
TAH
I
A
L
M
D
I
D
PT
R
LEESH
I
--V
V
R
K
L
MD
S
AG
ASG
K
ITC
H
T
Q
Q
K
EAL
Q
DADFV
VVAF
QI
G
G
Y
E
P
C
TVT
D
F
E
VCK
RHG
-
L
E
Q
TIAD
T
L
GPGGI
MR
A
LRTIP
H
L
W
QI
C
E
DM
T
E
V
CP
D
A
T
MLNY
V
NP
M
AM
N
T
W
A
M
Y
A
RY
P
HI
K
Q
V
GLCH
S
VQ
G
TAEE
L
A
RD
L
N
I
-
D
PAT
LR
Y
R
CA
G
I
NHM
AFYLE
L
E
R
KTAD
G
S
YV
N
L
Y
PELL
--
-
-
--------------
A
AYEA
GQA
PK
PN
I
HG-
-----------
--
NT
RC
Q
N
IV
R
Y
E
M
F
K
K
L
G
YFVT
E
SS
EH
F-
A
EYTPW
F
I
K
PG
RED
L
I
E
R
YK
V
P
LDEYPKRCVE
Q
L
ANWH
KELE
EYKN
A
SRI
D
I
KPSREY
A
S
TI
M
NAI
W
T
--------
G
E
P
S
VI
Y
G
N
----------------
V
R
N
D
G
L
IDN
L
P
QGCC
VE
V
A
C
L
V
D
A
NG
IQ
P
T
-
----
K
V
GT
L
PSHLA
A
LM
Q
T
NIN
V
Q
T
L
LT
E
A
I
L
TENRDR
V
YH
A
AM
MD
P
HTA
A
V
L
G
IDE
I
Y
AL
V
D
D
LI
A
AH
GD
WLP
GW
fig|679204.3.peg.3960
Escherichia coli MS 145-7 (6-448/451)
K
IT
F
IG
A
GST
I
FV
KN
ILG
D
V
FHREA
L
K
TAH
I
A
L
M
D
I
D
PT
R
LEESH
I
--V
V
R
K
L
MD
S
AG
ASG
K
ITC
H
T
Q
Q
K
EAL
Q
DADFV
VVAF
QI
G
G
Y
E
P
C
TVT
D
F
E
VCK
RHG
-
L
E
Q
TIAD
T
L
GPGGI
MR
A
LRTIP
H
L
W
QI
C
E
DM
T
E
V
CP
D
A
T
MLNY
V
NP
M
AM
N
T
W
A
M
Y
A
RY
P
HI
K
Q
V
GLCH
S
VQ
G
TAEE
L
A
RD
L
N
I
-
D
PAT
LR
Y
R
CA
G
I
NHM
AFYLE
L
E
R
KTAD
G
S
YV
N
L
Y
PELL
--
-
-
--------------
A
AYEA
GQA
PK
PN
I
HG-
-----------
--
NT
RC
Q
N
IV
R
Y
E
M
F
K
K
L
G
YFVT
E
SS
EH
F-
A
EYTPW
F
I
K
PG
RED
L
I
E
R
YK
V
P
LDEYPKRCVE
Q
L
ANWH
KELE
EYKN
A
SRI
D
I
KPSREY
A
S
TI
M
NAI
W
T
--------
G
E
P
S
VI
Y
G
N
----------------
V
R
N
D
G
L
IDN
L
P
QGCC
VE
V
A
C
L
V
D
A
NG
IQ
P
T
-
----
K
V
GT
L
PSHLA
A
LM
Q
T
NIN
V
Q
T
L
LT
E
A
I
L
TENRDR
V
YH
A
AM
MD
P
HTA
A
V
L
G
IDE
I
Y
AL
V
D
D
LI
A
AH
GD
WLP
GW
fig|749533.3.peg.4385
Escherichia coli MS 84-1 (6-448/451)
K
IT
F
IG
A
GST
I
FV
KN
ILG
D
V
FHREA
L
K
TAH
I
A
L
M
D
I
D
PT
R
LEESH
I
--V
V
R
K
L
MD
S
AG
ASG
K
ITC
H
T
Q
Q
K
EAL
Q
DADFV
VVAF
QI
G
G
Y
E
P
C
TVT
D
F
E
VCK
RHG
-
L
E
Q
TIAD
T
L
GPGGI
MR
A
LRTIP
H
L
W
QI
C
E
DM
T
E
V
CP
D
A
T
MLNY
V
NP
M
AM
N
T
W
A
M
Y
A
RY
P
HI
K
Q
V
GLCH
S
VQ
G
TAEE
L
A
RD
L
N
I
-
D
PAT
LR
Y
R
CA
G
I
NHM
AFYLE
L
E
R
KTAD
G
S
YV
N
L
Y
PELL
--
-
-
--------------
A
AYEA
GQA
PK
PN
I
HG-
-----------
--
NT
RC
Q
N
IV
R
Y
E
M
F
K
K
L
G
YFVT
E
SS
EH
F-
A
EYTPW
F
I
K
PG
RED
L
I
E
R
YK
V
P
LDEYPKRCVE
Q
L
ANWH
KELE
EYKN
A
SRI
D
I
KPSREY
A
S
TI
M
NAI
W
T
--------
G
E
P
S
VI
Y
G
N
----------------
V
R
N
D
G
L
IDN
L
P
QGCC
VE
V
A
C
L
V
D
A
NG
IQ
P
T
-
----
K
V
GT
L
PSHLA
A
LM
Q
T
NIN
V
Q
T
L
LT
E
A
I
L
TENRDR
V
YH
A
AM
MD
P
HTA
A
V
L
G
IDE
I
Y
AL
V
D
D
LI
A
AH
GD
WLP
GW
fig|585395.4.peg.5115
Escherichia coli O103:H2 str. 12009 (6-448/451)
K
IT
F
IG
A
GST
I
FV
KN
ILG
D
V
FHREA
L
K
TAH
I
A
L
M
D
I
D
PT
R
LEESH
I
--V
V
R
K
L
MD
S
AG
ASG
K
ITC
H
T
Q
Q
K
EAL
Q
DADFV
VVAF
QI
G
G
Y
E
P
C
TVT
D
F
E
VCK
RHG
-
L
E
Q
TIAD
T
L
GPGGI
MR
A
LRTIP
H
L
W
QI
C
E
DM
T
E
V
CP
D
A
T
MLNY
V
NP
M
AM
N
T
W
A
M
Y
A
RY
P
HI
K
Q
V
GLCH
S
VQ
G
TAEE
L
A
RD
L
N
I
-
D
PAT
LR
Y
R
CA
G
I
NHM
AFYLE
L
E
R
KTAD
G
S
YV
N
L
Y
PELL
--
-
-
--------------
A
AYEA
GQA
PK
PN
I
HG-
-----------
--
NT
RC
Q
N
IV
R
Y
E
M
F
K
K
L
G
YFVT
E
SS
EH
F-
A
EYTPW
F
I
K
PG
RED
L
I
E
R
YK
V
P
LDEYPKRCVE
Q
L
ANWH
KELE
EYKN
A
SRI
D
I
KPSREY
A
S
TI
M
NAI
W
T
--------
G
E
P
S
VI
Y
G
N
----------------
V
R
N
D
G
L
IDN
L
P
QGCC
VE
V
A
C
L
V
D
A
NG
IQ
P
T
-
----
K
V
GT
L
PSHLA
A
LM
Q
T
NIN
V
Q
T
L
LT
E
A
I
L
TENRDR
V
YH
A
AM
MD
P
HTA
A
V
L
G
IDE
I
Y
AL
V
D
D
LI
A
AH
GD
WLP
GW
fig|656443.3.peg.5105
Escherichia coli TA271 (6-448/451)
K
IT
F
IG
A
GST
I
FV
KN
ILG
D
V
FHREA
L
K
TAH
I
A
L
M
D
I
D
PT
R
LEESH
I
--V
V
R
K
L
MD
S
AG
ASG
K
ITC
H
T
Q
Q
K
EAL
Q
DADFV
VVAF
QI
G
G
Y
E
P
C
TVT
D
F
E
VCK
RHG
-
L
E
Q
TIAD
T
L
GPGGI
MR
A
LRTIP
H
L
W
QI
C
E
DM
T
E
V
CP
D
A
T
MLNY
V
NP
M
AM
N
T
W
A
M
Y
A
RY
P
HI
K
Q
V
GLCH
S
VQ
G
TAEE
L
A
RD
L
N
I
-
D
PAT
LR
Y
R
CA
G
I
NHM
AFYLE
L
E
R
KTAD
G
S
YV
N
L
Y
PELL
--
-
-
--------------
A
AYEA
GQA
PK
PN
I
HG-
-----------
--
NT
RC
Q
N
IV
R
Y
E
M
F
K
K
L
G
YFVT
E
SS
EH
F-
A
EYTPW
F
I
K
PG
RED
L
I
E
R
YK
V
P
LDEYPKRCVE
Q
L
ANWH
KELE
EYKN
A
SRI
D
I
KPSREY
A
S
TI
M
NAI
W
T
--------
G
E
P
S
VI
Y
G
N
----------------
V
R
N
D
G
L
IDN
L
P
QGCC
VE
V
A
C
L
V
D
A
NG
IQ
P
T
-
----
K
V
GT
L
PSHLA
A
LM
Q
T
NIN
V
Q
T
L
LT
E
A
I
L
TENRDR
V
YH
A
AM
MD
P
HTA
A
V
L
G
IDE
I
Y
AL
V
D
D
LI
A
AH
GD
WLP
GW
fig|550676.3.peg.4394
Escherichia coli B185 (1-448/451)
M
MSA
P
K
IT
F
IG
A
GST
I
FV
KN
ILG
D
V
FHREA
L
K
TAH
I
A
L
M
D
I
D
PT
R
LEESH
I
--V
V
R
K
L
MD
S
AG
ASG
K
ITC
H
T
Q
Q
K
EAL
E
DADFV
VVAF
QI
G
G
Y
E
P
C
TVT
D
F
E
VCK
RHG
-
L
E
Q
TIAD
T
L
GPGGI
MR
A
LRTIP
H
L
W
QI
C
E
DM
T
E
V
CP
D
A
T
MLNY
V
NP
M
AM
N
T
W
A
M
Y
A
RY
P
HI
K
Q
V
GLCH
S
VQ
G
TAEE
L
A
RD
L
N
I
-
D
PAT
LR
Y
R
CA
G
I
NHM
AFYLE
L
E
R
KTAD
G
S
YV
N
L
Y
PELL
--
-
-
--------------
A
AYEA
GQA
PK
PN
I
HG-
-----------
--
NT
RC
Q
N
IV
R
Y
E
M
F
K
K
L
G
YFVT
E
SS
EH
F-
A
EYTPW
F
I
K
PG
RED
L
I
E
R
YK
V
P
LDEYPKRCVE
Q
L
ANWH
KELE
EYKN
A
SRI
D
I
KPSREY
A
S
TI
M
NAI
W
T
--------
G
E
P
S
VI
Y
G
N
----------------
V
R
N
D
G
L
IDN
L
P
QGCC
VE
V
A
C
L
V
D
A
NG
IQ
P
T
-
----
K
V
GT
L
PSHLA
A
LM
Q
T
NIN
V
Q
T
L
LT
E
A
I
L
TENRDR
V
YH
A
AM
MD
P
HTA
A
V
L
G
IDE
I
Y
AL
V
D
D
LI
A
AH
GD
WLP
GW
fig|331112.3.peg.4074
Escherichia coli HS (6-448/451)
K
IT
F
IG
A
GST
I
FV
KN
ILG
D
V
FHREA
L
K
TAH
I
A
L
M
D
I
D
PT
R
LEESH
I
--V
V
R
K
L
MD
S
AG
ASG
K
ITC
H
T
Q
Q
K
EAL
E
DADFV
VVAF
QI
G
G
Y
E
P
C
TVT
D
F
E
VCK
RHG
-
L
E
Q
TIAD
T
L
GPGGI
MR
A
LRTIP
H
L
W
QI
C
E
DM
T
E
V
CP
D
A
T
MLNY
V
NP
M
AM
N
T
W
A
M
Y
A
RY
P
HI
K
Q
V
GLCH
S
VQ
G
TAEE
L
A
RD
L
N
I
-
D
PAT
LR
Y
R
CA
G
I
NHM
AFYLE
L
E
R
KTAD
G
S
YV
N
L
Y
PELL
--
-
-
--------------
A
AYEA
GQA
PK
PN
I
HG-
-----------
--
NT
RC
Q
N
IV
R
Y
E
M
F
K
K
L
G
YFVT
E
SS
EH
F-
A
EYTPW
F
I
K
PG
RED
L
I
E
R
YK
V
P
LDEYPKRCVE
Q
L
ANWH
KELE
EYKN
A
SRI
D
I
KPSREY
A
S
TI
M
NAI
W
T
--------
G
E
P
S
VI
Y
G
N
----------------
V
R
N
D
G
L
IDN
L
P
QGCC
VE
V
A
C
L
V
D
A
NG
IQ
P
T
-
----
K
V
GT
L
PSHLA
A
LM
Q
T
NIN
V
Q
T
L
LT
E
A
I
L
TENRDR
V
YH
A
AM
MD
P
HTA
A
V
L
G
IDE
I
Y
AL
V
D
D
LI
A
AH
GD
WLP
GW
fig|331112.6.peg.4248
Escherichia coli HS (6-448/451)
K
IT
F
IG
A
GST
I
FV
KN
ILG
D
V
FHREA
L
K
TAH
I
A
L
M
D
I
D
PT
R
LEESH
I
--V
V
R
K
L
MD
S
AG
ASG
K
ITC
H
T
Q
Q
K
EAL
E
DADFV
VVAF
QI
G
G
Y
E
P
C
TVT
D
F
E
VCK
RHG
-
L
E
Q
TIAD
T
L
GPGGI
MR
A
LRTIP
H
L
W
QI
C
E
DM
T
E
V
CP
D
A
T
MLNY
V
NP
M
AM
N
T
W
A
M
Y
A
RY
P
HI
K
Q
V
GLCH
S
VQ
G
TAEE
L
A
RD
L
N
I
-
D
PAT
LR
Y
R
CA
G
I
NHM
AFYLE
L
E
R
KTAD
G
S
YV
N
L
Y
PELL
--
-
-
--------------
A
AYEA
GQA
PK
PN
I
HG-
-----------
--
NT
RC
Q
N
IV
R
Y
E
M
F
K
K
L
G
YFVT
E
SS
EH
F-
A
EYTPW
F
I
K
PG
RED
L
I
E
R
YK
V
P
LDEYPKRCVE
Q
L
ANWH
KELE
EYKN
A
SRI
D
I
KPSREY
A
S
TI
M
NAI
W
T
--------
G
E
P
S
VI
Y
G
N
----------------
V
R
N
D
G
L
IDN
L
P
QGCC
VE
V
A
C
L
V
D
A
NG
IQ
P
T
-
----
K
V
GT
L
PSHLA
A
LM
Q
T
NIN
V
Q
T
L
LT
E
A
I
L
TENRDR
V
YH
A
AM
MD
P
HTA
A
V
L
G
IDE
I
Y
AL
V
D
D
LI
A
AH
GD
WLP
GW
fig|585034.4.peg.4227
Escherichia coli IAI1 (6-448/451)
K
IT
F
IG
A
GST
I
FV
KN
ILG
D
V
FHREA
L
K
TAH
I
A
L
M
D
I
D
PT
R
LEESH
I
--V
V
R
K
L
MD
S
AG
ASG
K
ITC
H
T
Q
Q
K
EAL
E
DADFV
VVAF
QI
G
G
Y
E
P
C
TVT
D
F
E
VCK
RHG
-
L
E
Q
TIAD
T
L
GPGGI
MR
A
LRTIP
H
L
W
QI
C
E
DM
T
E
V
CP
D
A
T
MLNY
V
NP
M
AM
N
T
W
A
M
Y
A
RY
P
HI
K
Q
V
GLCH
S
VQ
G
TAEE
L
A
RD
L
N
I
-
D
PAT
LR
Y
R
CA
G
I
NHM
AFYLE
L
E
R
KTAD
G
S
YV
N
L
Y
PELL
--
-
-
--------------
A
AYEA
GQA
PK
PN
I
HG-
-----------
--
NT
RC
Q
N
IV
R
Y
E
M
F
K
K
L
G
YFVT
E
SS
EH
F-
A
EYTPW
F
I
K
PG
RED
L
I
E
R
YK
V
P
LDEYPKRCVE
Q
L
ANWH
KELE
EYKN
A
SRI
D
I
KPSREY
A
S
TI
M
NAI
W
T
--------
G
E
P
S
VI
Y
G
N
----------------
V
R
N
D
G
L
IDN
L
P
QGCC
VE
V
A
C
L
V
D
A
NG
IQ
P
T
-
----
K
V
GT
L
PSHLA
A
LM
Q
T
NIN
V
Q
T
L
LT
E
A
I
L
TENRDR
V
YH
A
AM
MD
P
HTA
A
V
L
G
IDE
I
Y
AL
V
D
D
LI
A
AH
GD
WLP
GW
fig|585034.5.peg.4222
Escherichia coli IAI1 (6-448/451)
K
IT
F
IG
A
GST
I
FV
KN
ILG
D
V
FHREA
L
K
TAH
I
A
L
M
D
I
D
PT
R
LEESH
I
--V
V
R
K
L
MD
S
AG
ASG
K
ITC
H
T
Q
Q
K
EAL
E
DADFV
VVAF
QI
G
G
Y
E
P
C
TVT
D
F
E
VCK
RHG
-
L
E
Q
TIAD
T
L
GPGGI
MR
A
LRTIP
H
L
W
QI
C
E
DM
T
E
V
CP
D
A
T
MLNY
V
NP
M
AM
N
T
W
A
M
Y
A
RY
P
HI
K
Q
V
GLCH
S
VQ
G
TAEE
L
A
RD
L
N
I
-
D
PAT
LR
Y
R
CA
G
I
NHM
AFYLE
L
E
R
KTAD
G
S
YV
N
L
Y
PELL
--
-
-
--------------
A
AYEA
GQA
PK
PN
I
HG-
-----------
--
NT
RC
Q
N
IV
R
Y
E
M
F
K
K
L
G
YFVT
E
SS
EH
F-
A
EYTPW
F
I
K
PG
RED
L
I
E
R
YK
V
P
LDEYPKRCVE
Q
L
ANWH
KELE
EYKN
A
SRI
D
I
KPSREY
A
S
TI
M
NAI
W
T
--------
G
E
P
S
VI
Y
G
N
----------------
V
R
N
D
G
L
IDN
L
P
QGCC
VE
V
A
C
L
V
D
A
NG
IQ
P
T
-
----
K
V
GT
L
PSHLA
A
LM
Q
T
NIN
V
Q
T
L
LT
E
A
I
L
TENRDR
V
YH
A
AM
MD
P
HTA
A
V
L
G
IDE
I
Y
AL
V
D
D
LI
A
AH
GD
WLP
GW
fig|679207.4.peg.3007
Escherichia coli MS 107-1 (6-448/451)
K
IT
F
IG
A
GST
I
FV
KN
ILG
D
V
FHREA
L
K
TAH
I
A
L
M
D
I
D
PT
R
LEESH
I
--V
V
R
K
L
MD
S
AG
ASG
K
ITC
H
T
Q
Q
K
EAL
E
DADFV
VVAF
QI
G
G
Y
E
P
C
TVT
D
F
E
VCK
RHG
-
L
E
Q
TIAD
T
L
GPGGI
MR
A
LRTIP
H
L
W
QI
C
E
DM
T
E
V
CP
D
A
T
MLNY
V
NP
M
AM
N
T
W
A
M
Y
A
RY
P
HI
K
Q
V
GLCH
S
VQ
G
TAEE
L
A
RD
L
N
I
-
D
PAT
LR
Y
R
CA
G
I
NHM
AFYLE
L
E
R
KTAD
G
S
YV
N
L
Y
PELL
--
-
-
--------------
A
AYEA
GQA
PK
PN
I
HG-
-----------
--
NT
RC
Q
N
IV
R
Y
E
M
F
K
K
L
G
YFVT
E
SS
EH
F-
A
EYTPW
F
I
K
PG
RED
L
I
E
R
YK
V
P
LDEYPKRCVE
Q
L
ANWH
KELE
EYKN
A
SRI
D
I
KPSREY
A
S
TI
M
NAI
W
T
--------
G
E
P
S
VI
Y
G
N
----------------
V
R
N
D
G
L
IDN
L
P
QGCC
VE
V
A
C
L
V
D
A
NG
IQ
P
T
-
----
K
V
GT
L
PSHLA
A
LM
Q
T
NIN
V
Q
T
L
LT
E
A
I
L
TENRDR
V
YH
A
AM
MD
P
HTA
A
V
L
G
IDE
I
Y
AL
V
D
D
LI
A
AH
GD
WLP
GW
fig|749537.3.peg.4288
Escherichia coli MS 115-1 (6-448/451)
K
IT
F
IG
A
GST
I
FV
KN
ILG
D
V
FHREA
L
K
TAH
I
A
L
M
D
I
D
PT
R
LEESH
I
--V
V
R
K
L
MD
S
AG
ASG
K
ITC
H
T
Q
Q
K
EAL
E
DADFV
VVAF
QI
G
G
Y
E
P
C
TVT
D
F
E
VCK
RHG
-
L
E
Q
TIAD
T
L
GPGGI
MR
A
LRTIP
H
L
W
QI
C
E
DM
T
E
V
CP
D
A
T
MLNY
V
NP
M
AM
N
T
W
A
M
Y
A
RY
P
HI
K
Q
V
GLCH
S
VQ
G
TAEE
L
A
RD
L
N
I
-
D
PAT
LR
Y
R
CA
G
I
NHM
AFYLE
L
E
R
KTAD
G
S
YV
N
L
Y
PELL
--
-
-
--------------
A
AYEA
GQA
PK
PN
I
HG-
-----------
--
NT
RC
Q
N
IV
R
Y
E
M
F
K
K
L
G
YFVT
E
SS
EH
F-
A
EYTPW
F
I
K
PG
RED
L
I
E
R
YK
V
P
LDEYPKRCVE
Q
L
ANWH
KELE
EYKN
A
SRI
D
I
KPSREY
A
S
TI
M
NAI
W
T
--------
G
E
P
S
VI
Y
G
N
----------------
V
R
N
D
G
L
IDN
L
P
QGCC
VE
V
A
C
L
V
D
A
NG
IQ
P
T
-
----
K
V
GT
L
PSHLA
A
LM
Q
T
NIN
V
Q
T
L
LT
E
A
I
L
TENRDR
V
YH
A
AM
MD
P
HTA
A
V
L
G
IDE
I
Y
AL
V
D
D
LI
A
AH
GD
WLP
GW
fig|409438.11.peg.4599
Escherichia coli SE11 (6-448/451)
K
IT
F
IG
A
GST
I
FV
KN
ILG
D
V
FHREA
L
K
TAH
I
A
L
M
D
I
D
PT
R
LEESH
I
--V
V
R
K
L
MD
S
AG
ASG
K
ITC
H
T
Q
Q
K
EAL
E
DADFV
VVAF
QI
G
G
Y
E
P
C
TVT
D
F
E
VCK
RHG
-
L
E
Q
TIAD
T
L
GPGGI
MR
A
LRTIP
H
L
W
QI
C
E
DM
T
E
V
CP
D
A
T
MLNY
V
NP
M
AM
N
T
W
A
M
Y
A
RY
P
HI
K
Q
V
GLCH
S
VQ
G
TAEE
L
A
RD
L
N
I
-
D
PAT
LR
Y
R
CA
G
I
NHM
AFYLE
L
E
R
KTAD
G
S
YV
N
L
Y
PELL
--
-
-
--------------
A
AYEA
GQA
PK
PN
I
HG-
-----------
--
NT
RC
Q
N
IV
R
Y
E
M
F
K
K
L
G
YFVT
E
SS
EH
F-
A
EYTPW
F
I
K
PG
RED
L
I
E
R
YK
V
P
LDEYPKRCVE
Q
L
ANWH
KELE
EYKN
A
SRI
D
I
KPSREY
A
S
TI
M
NAI
W
T
--------
G
E
P
S
VI
Y
G
N
----------------
V
R
N
D
G
L
IDN
L
P
QGCC
VE
V
A
C
L
V
D
A
NG
IQ
P
T
-
----
K
V
GT
L
PSHLA
A
LM
Q
T
NIN
V
Q
T
L
LT
E
A
I
L
TENRDR
V
YH
A
AM
MD
P
HTA
A
V
L
G
IDE
I
Y
AL
V
D
D
LI
A
AH
GD
WLP
GW
fig|562.371.peg.3637
Escherichia coli 1044A (1-448/451)
M
MSA
P
K
IT
F
IG
A
GST
I
FV
KN
ILG
D
V
FHREA
L
K
TAH
I
A
L
M
D
I
D
PT
R
LEESH
I
--V
V
R
K
L
MD
S
AG
ASG
K
ITC
H
T
Q
Q
K
EAL
Q
DADFV
VVAF
QI
G
G
Y
A
P
C
TVT
D
F
E
VCK
RHG
-
L
E
Q
TIAD
T
L
GPGGI
MR
A
LRTIP
H
L
W
QI
C
E
DM
T
E
V
CP
D
A
T
MLNY
V
NP
M
AM
N
T
W
A
M
Y
A
RY
P
HI
K
Q
V
GLCH
S
VQ
G
TAEE
L
A
RD
L
N
I
-
D
PAT
LR
Y
R
CA
G
I
NHM
AFYLE
L
E
R
KTAD
G
S
YV
N
L
Y
PELL
--
-
-
--------------
A
AYDA
GQA
PK
PN
I
HG-
-----------
--
NT
RC
Q
N
IV
R
Y
E
M
F
K
K
L
G
YFVT
E
SS
EH
F-
A
EYTPW
F
I
K
PG
RED
L
I
E
R
YK
V
P
LDEYPKRCVE
Q
L
ANWH
KELE
EYKN
A
SRI
D
I
KPSREY
A
S
TI
M
NAI
W
T
--------
G
E
P
S
VI
Y
G
N
----------------
V
R
N
D
G
L
IDN
L
P
QGCC
VE
V
A
C
L
V
D
A
NG
IQ
P
T
-
----
K
V
GT
L
PSHLA
A
LM
Q
T
NIN
V
Q
T
L
LT
E
A
I
L
TENRDR
V
YH
A
AM
MD
P
HTA
A
V
L
G
IDE
I
Y
AL
V
D
D
LI
A
AH
GD
WLP
GW
fig|562.373.peg.5766
Escherichia coli 1125A (1-448/451)
M
MSA
P
K
IT
F
IG
A
GST
I
FV
KN
ILG
D
V
FHREA
L
K
TAH
I
A
L
M
D
I
D
PT
R
LEESH
I
--V
V
R
K
L
MD
S
AG
ASG
K
ITC
H
T
Q
Q
K
EAL
Q
DADFV
VVAF
QI
G
G
Y
A
P
C
TVT
D
F
E
VCK
RHG
-
L
E
Q
TIAD
T
L
GPGGI
MR
A
LRTIP
H
L
W
QI
C
E
DM
T
E
V
CP
D
A
T
MLNY
V
NP
M
AM
N
T
W
A
M
Y
A
RY
P
HI
K
Q
V
GLCH
S
VQ
G
TAEE
L
A
RD
L
N
I
-
D
PAT
LR
Y
R
CA
G
I
NHM
AFYLE
L
E
R
KTAD
G
S
YV
N
L
Y
PELL
--
-
-
--------------
A
AYDA
GQA
PK
PN
I
HG-
-----------
--
NT
RC
Q
N
IV
R
Y
E
M
F
K
K
L
G
YFVT
E
SS
EH
F-
A
EYTPW
F
I
K
PG
RED
L
I
E
R
YK
V
P
LDEYPKRCVE
Q
L
ANWH
KELE
EYKN
A
SRI
D
I
KPSREY
A
S
TI
M
NAI
W
T
--------
G
E
P
S
VI
Y
G
N
----------------
V
R
N
D
G
L
IDN
L
P
QGCC
VE
V
A
C
L
V
D
A
NG
IQ
P
T
-
----
K
V
GT
L
PSHLA
A
LM
Q
T
NIN
V
Q
T
L
LT
E
A
I
L
TENRDR
V
YH
A
AM
MD
P
HTA
A
V
L
G
IDE
I
Y
AL
V
D
D
LI
A
AH
GD
WLP
GW
fig|562.372.peg.3421
Escherichia coli 1212A (1-448/451)
M
MSA
P
K
IT
F
IG
A
GST
I
FV
KN
ILG
D
V
FHREA
L
K
TAH
I
A
L
M
D
I
D
PT
R
LEESH
I
--V
V
R
K
L
MD
S
AG
ASG
K
ITC
H
T
Q
Q
K
EAL
Q
DADFV
VVAF
QI
G
G
Y
A
P
C
TVT
D
F
E
VCK
RHG
-
L
E
Q
TIAD
T
L
GPGGI
MR
A
LRTIP
H
L
W
QI
C
E
DM
T
E
V
CP
D
A
T
MLNY
V
NP
M
AM
N
T
W
A
M
Y
A
RY
P
HI
K
Q
V
GLCH
S
VQ
G
TAEE
L
A
RD
L
N
I
-
D
PAT
LR
Y
R
CA
G
I
NHM
AFYLE
L
E
R
KTAD
G
S
YV
N
L
Y
PELL
--
-
-
--------------
A
AYDA
GQA
PK
PN
I
HG-
-----------
--
NT
RC
Q
N
IV
R
Y
E
M
F
K
K
L
G
YFVT
E
SS
EH
F-
A
EYTPW
F
I
K
PG
RED
L
I
E
R
YK
V
P
LDEYPKRCVE
Q
L
ANWH
KELE
EYKN
A
SRI
D
I
KPSREY
A
S
TI
M
NAI
W
T
--------
G
E
P
S
VI
Y
G
N
----------------
V
R
N
D
G
L
IDN
L
P
QGCC
VE
V
A
C
L
V
D
A
NG
IQ
P
T
-
----
K
V
GT
L
PSHLA
A
LM
Q
T
NIN
V
Q
T
L
LT
E
A
I
L
TENRDR
V
YH
A
AM
MD
P
HTA
A
V
L
G
IDE
I
Y
AL
V
D
D
LI
A
AH
GD
WLP
GW
fig|562.374.peg.2756
Escherichia coli 536A (1-448/451)
M
MSA
P
K
IT
F
IG
A
GST
I
FV
KN
ILG
D
V
FHREA
L
K
TAH
I
A
L
M
D
I
D
PT
R
LEESH
I
--V
V
R
K
L
MD
S
AG
ASG
K
ITC
H
T
Q
Q
K
EAL
Q
DADFV
VVAF
QI
G
G
Y
A
P
C
TVT
D
F
E
VCK
RHG
-
L
E
Q
TIAD
T
L
GPGGI
MR
A
LRTIP
H
L
W
QI
C
E
DM
T
E
V
CP
D
A
T
MLNY
V
NP
M
AM
N
T
W
A
M
Y
A
RY
P
HI
K
Q
V
GLCH
S
VQ
G
TAEE
L
A
RD
L
N
I
-
D
PAT
LR
Y
R
CA
G
I
NHM
AFYLE
L
E
R
KTAD
G
S
YV
N
L
Y
PELL
--
-
-
--------------
A
AYDA
GQA
PK
PN
I
HG-
-----------
--
NT
RC
Q
N
IV
R
Y
E
M
F
K
K
L
G
YFVT
E
SS
EH
F-
A
EYTPW
F
I
K
PG
RED
L
I
E
R
YK
V
P
LDEYPKRCVE
Q
L
ANWH
KELE
EYKN
A
SRI
D
I
KPSREY
A
S
TI
M
NAI
W
T
--------
G
E
P
S
VI
Y
G
N
----------------
V
R
N
D
G
L
IDN
L
P
QGCC
VE
V
A
C
L
V
D
A
NG
IQ
P
T
-
----
K
V
GT
L
PSHLA
A
LM
Q
T
NIN
V
Q
T
L
LT
E
A
I
L
TENRDR
V
YH
A
AM
MD
P
HTA
A
V
L
G
IDE
I
Y
AL
V
D
D
LI
A
AH
GD
WLP
GW
fig|83334.1.peg.5079
Escherichia coli O157:H7 (1-448/451)
M
MSA
P
K
IT
F
IG
A
GST
I
FV
KN
ILG
D
V
FHREA
L
K
TAH
I
A
L
M
D
I
D
PT
R
LEESH
I
--V
V
R
K
L
MD
S
AG
ASG
K
ITC
H
T
Q
Q
K
EAL
Q
DADFV
VVAF
QI
G
G
Y
A
P
C
TVT
D
F
E
VCK
RHG
-
L
E
Q
TIAD
T
L
GPGGI
MR
A
LRTIP
H
L
W
QI
C
E
DM
T
E
V
CP
D
A
T
MLNY
V
NP
M
AM
N
T
W
A
M
Y
A
RY
P
HI
K
Q
V
GLCH
S
VQ
G
TAEE
L
A
RD
L
N
I
-
D
PAT
LR
Y
R
CA
G
I
NHM
AFYLE
L
E
R
KTAD
G
S
YV
N
L
Y
PELL
--
-
-
--------------
A
AYDA
GQA
PK
PN
I
HG-
-----------
--
NT
RC
Q
N
IV
R
Y
E
M
F
K
K
L
G
YFVT
E
SS
EH
F-
A
EYTPW
F
I
K
PG
RED
L
I
E
R
YK
V
P
LDEYPKRCVE
Q
L
ANWH
KELE
EYKN
A
SRI
D
I
KPSREY
A
S
TI
M
NAI
W
T
--------
G
E
P
S
VI
Y
G
N
----------------
V
R
N
D
G
L
IDN
L
P
QGCC
VE
V
A
C
L
V
D
A
NG
IQ
P
T
-
----
K
V
GT
L
PSHLA
A
LM
Q
T
NIN
V
Q
T
L
LT
E
A
I
L
TENRDR
V
YH
A
AM
MD
P
HTA
A
V
L
G
IDE
I
Y
AL
V
D
D
LI
A
AH
GD
WLP
GW
fig|444454.5.peg.4183
Escherichia coli O157:H7 str. EC4024 (1-448/451)
M
MSA
P
K
IT
F
IG
A
GST
I
FV
KN
ILG
D
V
FHREA
L
K
TAH
I
A
L
M
D
I
D
PT
R
LEESH
I
--V
V
R
K
L
MD
S
AG
ASG
K
ITC
H
T
Q
Q
K
EAL
Q
DADFV
VVAF
QI
G
G
Y
A
P
C
TVT
D
F
E
VCK
RHG
-
L
E
Q
TIAD
T
L
GPGGI
MR
A
LRTIP
H
L
W
QI
C
E
DM
T
E
V
CP
D
A
T
MLNY
V
NP
M
AM
N
T
W
A
M
Y
A
RY
P
HI
K
Q
V
GLCH
S
VQ
G
TAEE
L
A
RD
L
N
I
-
D
PAT
LR
Y
R
CA
G
I
NHM
AFYLE
L
E
R
KTAD
G
S
YV
N
L
Y
PELL
--
-
-
--------------
A
AYDA
GQA
PK
PN
I
HG-
-----------
--
NT
RC
Q
N
IV
R
Y
E
M
F
K
K
L
G
YFVT
E
SS
EH
F-
A
EYTPW
F
I
K
PG
RED
L
I
E
R
YK
V
P
LDEYPKRCVE
Q
L
ANWH
KELE
EYKN
A
SRI
D
I
KPSREY
A
S
TI
M
NAI
W
T
--------
G
E
P
S
VI
Y
G
N
----------------
V
R
N
D
G
L
IDN
L
P
QGCC
VE
V
A
C
L
V
D
A
NG
IQ
P
T
-
----
K
V
GT
L
PSHLA
A
LM
Q
T
NIN
V
Q
T
L
LT
E
A
I
L
TENRDR
V
YH
A
AM
MD
P
HTA
A
V
L
G
IDE
I
Y
AL
V
D
D
LI
A
AH
GD
WLP
GW
fig|444449.5.peg.3637
Escherichia coli O157:H7 str. EC4042 (1-448/451)
M
MSA
P
K
IT
F
IG
A
GST
I
FV
KN
ILG
D
V
FHREA
L
K
TAH
I
A
L
M
D
I
D
PT
R
LEESH
I
--V
V
R
K
L
MD
S
AG
ASG
K
ITC
H
T
Q
Q
K
EAL
Q
DADFV
VVAF
QI
G
G
Y
A
P
C
TVT
D
F
E
VCK
RHG
-
L
E
Q
TIAD
T
L
GPGGI
MR
A
LRTIP
H
L
W
QI
C
E
DM
T
E
V
CP
D
A
T
MLNY
V
NP
M
AM
N
T
W
A
M
Y
A
RY
P
HI
K
Q
V
GLCH
S
VQ
G
TAEE
L
A
RD
L
N
I
-
D
PAT
LR
Y
R
CA
G
I
NHM
AFYLE
L
E
R
KTAD
G
S
YV
N
L
Y
PELL
--
-
-
--------------
A
AYDA
GQA
PK
PN
I
HG-
-----------
--
NT
RC
Q
N
IV
R
Y
E
M
F
K
K
L
G
YFVT
E
SS
EH
F-
A
EYTPW
F
I
K
PG
RED
L
I
E
R
YK
V
P
LDEYPKRCVE
Q
L
ANWH
KELE
EYKN
A
SRI
D
I
KPSREY
A
S
TI
M
NAI
W
T
--------
G
E
P
S
VI
Y
G
N
----------------
V
R
N
D
G
L
IDN
L
P
QGCC
VE
V
A
C
L
V
D
A
NG
IQ
P
T
-
----
K
V
GT
L
PSHLA
A
LM
Q
T
NIN
V
Q
T
L
LT
E
A
I
L
TENRDR
V
YH
A
AM
MD
P
HTA
A
V
L
G
IDE
I
Y
AL
V
D
D
LI
A
AH
GD
WLP
GW
fig|444448.5.peg.2394
Escherichia coli O157:H7 str. EC4045 (1-448/451)
M
MSA
P
K
IT
F
IG
A
GST
I
FV
KN
ILG
D
V
FHREA
L
K
TAH
I
A
L
M
D
I
D
PT
R
LEESH
I
--V
V
R
K
L
MD
S
AG
ASG
K
ITC
H
T
Q
Q
K
EAL
Q
DADFV
VVAF
QI
G
G
Y
A
P
C
TVT
D
F
E
VCK
RHG
-
L
E
Q
TIAD
T
L
GPGGI
MR
A
LRTIP
H
L
W
QI
C
E
DM
T
E
V
CP
D
A
T
MLNY
V
NP
M
AM
N
T
W
A
M
Y
A
RY
P
HI
K
Q
V
GLCH
S
VQ
G
TAEE
L
A
RD
L
N
I
-
D
PAT
LR
Y
R
CA
G
I
NHM
AFYLE
L
E
R
KTAD
G
S
YV
N
L
Y
PELL
--
-
-
--------------
A
AYDA
GQA
PK
PN
I
HG-
-----------
--
NT
RC
Q
N
IV
R
Y
E
M
F
K
K
L
G
YFVT
E
SS
EH
F-
A
EYTPW
F
I
K
PG
RED
L
I
E
R
YK
V
P
LDEYPKRCVE
Q
L
ANWH
KELE
EYKN
A
SRI
D
I
KPSREY
A
S
TI
M
NAI
W
T
--------
G
E
P
S
VI
Y
G
N
----------------
V
R
N
D
G
L
IDN
L
P
QGCC
VE
V
A
C
L
V
D
A
NG
IQ
P
T
-
----
K
V
GT
L
PSHLA
A
LM
Q
T
NIN
V
Q
T
L
LT
E
A
I
L
TENRDR
V
YH
A
AM
MD
P
HTA
A
V
L
G
IDE
I
Y
AL
V
D
D
LI
A
AH
GD
WLP
GW
fig|444453.5.peg.2031
Escherichia coli O157:H7 str. EC4076 (1-448/451)
M
MSA
P
K
IT
F
IG
A
GST
I
FV
KN
ILG
D
V
FHREA
L
K
TAH
I
A
L
M
D
I
D
PT
R
LEESH
I
--V
V
R
K
L
MD
S
AG
ASG
K
ITC
H
T
Q
Q
K
EAL
Q
DADFV
VVAF
QI
G
G
Y
A
P
C
TVT
D
F
E
VCK
RHG
-
L
E
Q
TIAD
T
L
GPGGI
MR
A
LRTIP
H
L
W
QI
C
E
DM
T
E
V
CP
D
A
T
MLNY
V
NP
M
AM
N
T
W
A
M
Y
A
RY
P
HI
K
Q
V
GLCH
S
VQ
G
TAEE
L
A
RD
L
N
I
-
D
PAT
LR
Y
R
CA
G
I
NHM
AFYLE
L
E
R
KTAD
G
S
YV
N
L
Y
PELL
--
-
-
--------------
A
AYDA
GQA
PK
PN
I
HG-
-----------
--
NT
RC
Q
N
IV
R
Y
E
M
F
K
K
L
G
YFVT
E
SS
EH
F-
A
EYTPW
F
I
K
PG
RED
L
I
E
R
YK
V
P
LDEYPKRCVE
Q
L
ANWH
KELE
EYKN
A
SRI
D
I
KPSREY
A
S
TI
M
NAI
W
T
--------
G
E
P
S
VI
Y
G
N
----------------
V
R
N
D
G
L
IDN
L
P
QGCC
VE
V
A
C
L
V
D
A
NG
IQ
P
T
-
----
K
V
GT
L
PSHLA
A
LM
Q
T
NIN
V
Q
T
L
LT
E
A
I
L
TENRDR
V
YH
A
AM
MD
P
HTA
A
V
L
G
IDE
I
Y
AL
V
D
D
LI
A
AH
GD
WLP
GW
fig|444452.5.peg.1132
Escherichia coli O157:H7 str. EC4113 (1-448/451)
M
MSA
P
K
IT
F
IG
A
GST
I
FV
KN
ILG
D
V
FHREA
L
K
TAH
I
A
L
M
D
I
D
PT
R
LEESH
I
--V
V
R
K
L
MD
S
AG
ASG
K
ITC
H
T
Q
Q
K
EAL
Q
DADFV
VVAF
QI
G
G
Y
A
P
C
TVT
D
F
E
VCK
RHG
-
L
E
Q
TIAD
T
L
GPGGI
MR
A
LRTIP
H
L
W
QI
C
E
DM
T
E
V
CP
D
A
T
MLNY
V
NP
M
AM
N
T
W
A
M
Y
A
RY
P
HI
K
Q
V
GLCH
S
VQ
G
TAEE
L
A
RD
L
N
I
-
D
PAT
LR
Y
R
CA
G
I
NHM
AFYLE
L
E
R
KTAD
G
S
YV
N
L
Y
PELL
--
-
-
--------------
A
AYDA
GQA
PK
PN
I
HG-
-----------
--
NT
RC
Q
N
IV
R
Y
E
M
F
K
K
L
G
YFVT
E
SS
EH
F-
A
EYTPW
F
I
K
PG
RED
L
I
E
R
YK
V
P
LDEYPKRCVE
Q
L
ANWH
KELE
EYKN
A
SRI
D
I
KPSREY
A
S
TI
M
NAI
W
T
--------
G
E
P
S
VI
Y
G
N
----------------
V
R
N
D
G
L
IDN
L
P
QGCC
VE
V
A
C
L
V
D
A
NG
IQ
P
T
-
----
K
V
GT
L
PSHLA
A
LM
Q
T
NIN
V
Q
T
L
LT
E
A
I
L
TENRDR
V
YH
A
AM
MD
P
HTA
A
V
L
G
IDE
I
Y
AL
V
D
D
LI
A
AH
GD
WLP
GW
fig|444450.8.peg.5473
Escherichia coli O157:H7 str. EC4115 (1-448/451)
M
MSA
P
K
IT
F
IG
A
GST
I
FV
KN
ILG
D
V
FHREA
L
K
TAH
I
A
L
M
D
I
D
PT
R
LEESH
I
--V
V
R
K
L
MD
S
AG
ASG
K
ITC
H
T
Q
Q
K
EAL
Q
DADFV
VVAF
QI
G
G
Y
A
P
C
TVT
D
F
E
VCK
RHG
-
L
E
Q
TIAD
T
L
GPGGI
MR
A
LRTIP
H
L
W
QI
C
E
DM
T
E
V
CP
D
A
T
MLNY
V
NP
M
AM
N
T
W
A
M
Y
A
RY
P
HI
K
Q
V
GLCH
S
VQ
G
TAEE
L
A
RD
L
N
I
-
D
PAT
LR
Y
R
CA
G
I
NHM
AFYLE
L
E
R
KTAD
G
S
YV
N
L
Y
PELL
--
-
-
--------------
A
AYDA
GQA
PK
PN
I
HG-
-----------
--
NT
RC
Q
N
IV
R
Y
E
M
F
K
K
L
G
YFVT
E
SS
EH
F-
A
EYTPW
F
I
K
PG
RED
L
I
E
R
YK
V
P
LDEYPKRCVE
Q
L
ANWH
KELE
EYKN
A
SRI
D
I
KPSREY
A
S
TI
M
NAI
W
T
--------
G
E
P
S
VI
Y
G
N
----------------
V
R
N
D
G
L
IDN
L
P
QGCC
VE
V
A
C
L
V
D
A
NG
IQ
P
T
-
----
K
V
GT
L
PSHLA
A
LM
Q
T
NIN
V
Q
T
L
LT
E
A
I
L
TENRDR
V
YH
A
AM
MD
P
HTA
A
V
L
G
IDE
I
Y
AL
V
D
D
LI
A
AH
GD
WLP
GW
fig|444451.5.peg.2135
Escherichia coli O157:H7 str. EC4196 (1-448/451)
M
MSA
P
K
IT
F
IG
A
GST
I
FV
KN
ILG
D
V
FHREA
L
K
TAH
I
A
L
M
D
I
D
PT
R
LEESH
I
--V
V
R
K
L
MD
S
AG
ASG
K
ITC
H
T
Q
Q
K
EAL
Q
DADFV
VVAF
QI
G
G
Y
A
P
C
TVT
D
F
E
VCK
RHG
-
L
E
Q
TIAD
T
L
GPGGI
MR
A
LRTIP
H
L
W
QI
C
E
DM
T
E
V
CP
D
A
T
MLNY
V
NP
M
AM
N
T
W
A
M
Y
A
RY
P
HI
K
Q
V
GLCH
S
VQ
G
TAEE
L
A
RD
L
N
I
-
D
PAT
LR
Y
R
CA
G
I
NHM
AFYLE
L
E
R
KTAD
G
S
YV
N
L
Y
PELL
--
-
-
--------------
A
AYDA
GQA
PK
PN
I
HG-
-----------
--
NT
RC
Q
N
IV
R
Y
E
M
F
K
K
L
G
YFVT
E
SS
EH
F-
A
EYTPW
F
I
K
PG
RED
L
I
E
R
YK
V
P
LDEYPKRCVE
Q
L
ANWH
KELE
EYKN
A
SRI
D
I
KPSREY
A
S
TI
M
NAI
W
T
--------
G
E
P
S
VI
Y
G
N
----------------
V
R
N
D
G
L
IDN
L
P
QGCC
VE
V
A
C
L
V
D
A
NG
IQ
P
T
-
----
K
V
GT
L
PSHLA
A
LM
Q
T
NIN
V
Q
T
L
LT
E
A
I
L
TENRDR
V
YH
A
AM
MD
P
HTA
A
V
L
G
IDE
I
Y
AL
V
D
D
LI
A
AH
GD
WLP
GW
fig|444447.5.peg.2560
Escherichia coli O157:H7 str. EC4206 (1-448/451)
M
MSA
P
K
IT
F
IG
A
GST
I
FV
KN
ILG
D
V
FHREA
L
K
TAH
I
A
L
M
D
I
D
PT
R
LEESH
I
--V
V
R
K
L
MD
S
AG
ASG
K
ITC
H
T
Q
Q
K
EAL
Q
DADFV
VVAF
QI
G
G
Y
A
P
C
TVT
D
F
E
VCK
RHG
-
L
E
Q
TIAD
T
L
GPGGI
MR
A
LRTIP
H
L
W
QI
C
E
DM
T
E
V
CP
D
A
T
MLNY
V
NP
M
AM
N
T
W
A
M
Y
A
RY
P
HI
K
Q
V
GLCH
S
VQ
G
TAEE
L
A
RD
L
N
I
-
D
PAT
LR
Y
R
CA
G
I
NHM
AFYLE
L
E
R
KTAD
G
S
YV
N
L
Y
PELL
--
-
-
--------------
A
AYDA
GQA
PK
PN
I
HG-
-----------
--
NT
RC
Q
N
IV
R
Y
E
M
F
K
K
L
G
YFVT
E
SS
EH
F-
A
EYTPW
F
I
K
PG
RED
L
I
E
R
YK
V
P
LDEYPKRCVE
Q
L
ANWH
KELE
EYKN
A
SRI
D
I
KPSREY
A
S
TI
M
NAI
W
T
--------
G
E
P
S
VI
Y
G
N
----------------
V
R
N
D
G
L
IDN
L
P
QGCC
VE
V
A
C
L
V
D
A
NG
IQ
P
T
-
----
K
V
GT
L
PSHLA
A
LM
Q
T
NIN
V
Q
T
L
LT
E
A
I
L
TENRDR
V
YH
A
AM
MD
P
HTA
A
V
L
G
IDE
I
Y
AL
V
D
D
LI
A
AH
GD
WLP
GW
fig|478004.5.peg.2083
Escherichia coli O157:H7 str. EC4401 (1-448/451)
M
MSA
P
K
IT
F
IG
A
GST
I
FV
KN
ILG
D
V
FHREA
L
K
TAH
I
A
L
M
D
I
D
PT
R
LEESH
I
--V
V
R
K
L
MD
S
AG
ASG
K
ITC
H
T
Q
Q
K
EAL
Q
DADFV
VVAF
QI
G
G
Y
A
P
C
TVT
D
F
E
VCK
RHG
-
L
E
Q
TIAD
T
L
GPGGI
MR
A
LRTIP
H
L
W
QI
C
E
DM
T
E
V
CP
D
A
T
MLNY
V
NP
M
AM
N
T
W
A
M
Y
A
RY
P
HI
K
Q
V
GLCH
S
VQ
G
TAEE
L
A
RD
L
N
I
-
D
PAT
LR
Y
R
CA
G
I
NHM
AFYLE
L
E
R
KTAD
G
S
YV
N
L
Y
PELL
--
-
-
--------------
A
AYDA
GQA
PK
PN
I
HG-
-----------
--
NT
RC
Q
N
IV
R
Y
E
M
F
K
K
L
G
YFVT
E
SS
EH
F-
A
EYTPW
F
I
K
PG
RED
L
I
E
R
YK
V
P
LDEYPKRCVE
Q
L
ANWH
KELE
EYKN
A
SRI
D
I
KPSREY
A
S
TI
M
NAI
W
T
--------
G
E
P
S
VI
Y
G
N
----------------
V
R
N
D
G
L
IDN
L
P
QGCC
VE
V
A
C
L
V
D
A
NG
IQ
P
T
-
----
K
V
GT
L
PSHLA
A
LM
Q
T
NIN
V
Q
T
L
LT
E
A
I
L
TENRDR
V
YH
A
AM
MD
P
HTA
A
V
L
G
IDE
I
Y
AL
V
D
D
LI
A
AH
GD
WLP
GW
fig|478005.5.peg.613
Escherichia coli O157:H7 str. EC4486 (1-448/451)
M
MSA
P
K
IT
F
IG
A
GST
I
FV
KN
ILG
D
V
FHREA
L
K
TAH
I
A
L
M
D
I
D
PT
R
LEESH
I
--V
V
R
K
L
MD
S
AG
ASG
K
ITC
H
T
Q
Q
K
EAL
Q
DADFV
VVAF
QI
G
G
Y
A
P
C
TVT
D
F
E
VCK
RHG
-
L
E
Q
TIAD
T
L
GPGGI
MR
A
LRTIP
H
L
W
QI
C
E
DM
T
E
V
CP
D
A
T
MLNY
V
NP
M
AM
N
T
W
A
M
Y
A
RY
P
HI
K
Q
V
GLCH
S
VQ
G
TAEE
L
A
RD
L
N
I
-
D
PAT
LR
Y
R
CA
G
I
NHM
AFYLE
L
E
R
KTAD
G
S
YV
N
L
Y
PELL
--
-
-
--------------
A
AYDA
GQA
PK
PN
I
HG-
-----------
--
NT
RC
Q
N
IV
R
Y
E
M
F
K
K
L
G
YFVT
E
SS
EH
F-
A
EYTPW
F
I
K
PG
RED
L
I
E
R
YK
V
P
LDEYPKRCVE
Q
L
ANWH
KELE
EYKN
A
SRI
D
I
KPSREY
A
S
TI
M
NAI
W
T
--------
G
E
P
S
VI
Y
G
N
----------------
V
R
N
D
G
L
IDN
L
P
QGCC
VE
V
A
C
L
V
D
A
NG
IQ
P
T
-
----
K
V
GT
L
PSHLA
A
LM
Q
T
NIN
V
Q
T
L
LT
E
A
I
L
TENRDR
V
YH
A
AM
MD
P
HTA
A
V
L
G
IDE
I
Y
AL
V
D
D
LI
A
AH
GD
WLP
GW
fig|478006.5.peg.1497
Escherichia coli O157:H7 str. EC4501 (1-448/451)
M
MSA
P
K
IT
F
IG
A
GST
I
FV
KN
ILG
D
V
FHREA
L
K
TAH
I
A
L
M
D
I
D
PT
R
LEESH
I
--V
V
R
K
L
MD
S
AG
ASG
K
ITC
H
T
Q
Q
K
EAL
Q
DADFV
VVAF
QI
G
G
Y
A
P
C
TVT
D
F
E
VCK
RHG
-
L
E
Q
TIAD
T
L
GPGGI
MR
A
LRTIP
H
L
W
QI
C
E
DM
T
E
V
CP
D
A
T
MLNY
V
NP
M
AM
N
T
W
A
M
Y
A
RY
P
HI
K
Q
V
GLCH
S
VQ
G
TAEE
L
A
RD
L
N
I
-
D
PAT
LR
Y
R
CA
G
I
NHM
AFYLE
L
E
R
KTAD
G
S
YV
N
L
Y
PELL
--
-
-
--------------
A
AYDA
GQA
PK
PN
I
HG-
-----------
--
NT
RC
Q
N
IV
R
Y
E
M
F
K
K
L
G
YFVT
E
SS
EH
F-
A
EYTPW
F
I
K
PG
RED
L
I
E
R
YK
V
P
LDEYPKRCVE
Q
L
ANWH
KELE
EYKN
A
SRI
D
I
KPSREY
A
S
TI
M
NAI
W
T
--------
G
E
P
S
VI
Y
G
N
----------------
V
R
N
D
G
L
IDN
L
P
QGCC
VE
V
A
C
L
V
D
A
NG
IQ
P
T
-
----
K
V
GT
L
PSHLA
A
LM
Q
T
NIN
V
Q
T
L
LT
E
A
I
L
TENRDR
V
YH
A
AM
MD
P
HTA
A
V
L
G
IDE
I
Y
AL
V
D
D
LI
A
AH
GD
WLP
GW
fig|478007.5.peg.1040
Escherichia coli O157:H7 str. EC508 (1-448/451)
M
MSA
P
K
IT
F
IG
A
GST
I
FV
KN
ILG
D
V
FHREA
L
K
TAH
I
A
L
M
D
I
D
PT
R
LEESH
I
--V
V
R
K
L
MD
S
AG
ASG
K
ITC
H
T
Q
Q
K
EAL
Q
DADFV
VVAF
QI
G
G
Y
A
P
C
TVT
D
F
E
VCK
RHG
-
L
E
Q
TIAD
T
L
GPGGI
MR
A
LRTIP
H
L
W
QI
C
E
DM
T
E
V
CP
D
A
T
MLNY
V
NP
M
AM
N
T
W
A
M
Y
A
RY
P
HI
K
Q
V
GLCH
S
VQ
G
TAEE
L
A
RD
L
N
I
-
D
PAT
LR
Y
R
CA
G
I
NHM
AFYLE
L
E
R
KTAD
G
S
YV
N
L
Y
PELL
--
-
-
--------------
A
AYDA
GQA
PK
PN
I
HG-
-----------
--
NT
RC
Q
N
IV
R
Y
E
M
F
K
K
L
G
YFVT
E
SS
EH
F-
A
EYTPW
F
I
K
PG
RED
L
I
E
R
YK
V
P
LDEYPKRCVE
Q
L
ANWH
KELE
EYKN
A
SRI
D
I
KPSREY
A
S
TI
M
NAI
W
T
--------
G
E
P
S
VI
Y
G
N
----------------
V
R
N
D
G
L
IDN
L
P
QGCC
VE
V
A
C
L
V
D
A
NG
IQ
P
T
-
----
K
V
GT
L
PSHLA
A
LM
Q
T
NIN
V
Q
T
L
LT
E
A
I
L
TENRDR
V
YH
A
AM
MD
P
HTA
A
V
L
G
IDE
I
Y
AL
V
D
D
LI
A
AH
GD
WLP
GW
fig|478008.5.peg.146
Escherichia coli O157:H7 str. EC869 (1-448/451)
M
MSA
P
K
IT
F
IG
A
GST
I
FV
KN
ILG
D
V
FHREA
L
K
TAH
I
A
L
M
D
I
D
PT
R
LEESH
I
--V
V
R
K
L
MD
S
AG
ASG
K
ITC
H
T
Q
Q
K
EAL
Q
DADFV
VVAF
QI
G
G
Y
A
P
C
TVT
D
F
E
VCK
RHG
-
L
E
Q
TIAD
T
L
GPGGI
MR
A
LRTIP
H
L
W
QI
C
E
DM
T
E
V
CP
D
A
T
MLNY
V
NP
M
AM
N
T
W
A
M
Y
A
RY
P
HI
K
Q
V
GLCH
S
VQ
G
TAEE
L
A
RD
L
N
I
-
D
PAT
LR
Y
R
CA
G
I
NHM
AFYLE
L
E
R
KTAD
G
S
YV
N
L
Y
PELL
--
-
-
--------------
A
AYDA
GQA
PK
PN
I
HG-
-----------
--
NT
RC
Q
N
IV
R
Y
E
M
F
K
K
L
G
YFVT
E
SS
EH
F-
A
EYTPW
F
I
K
PG
RED
L
I
E
R
YK
V
P
LDEYPKRCVE
Q
L
ANWH
KELE
EYKN
A
SRI
D
I
KPSREY
A
S
TI
M
NAI
W
T
--------
G
E
P
S
VI
Y
G
N
----------------
V
R
N
D
G
L
IDN
L
P
QGCC
VE
V
A
C
L
V
D
A
NG
IQ
P
T
-
----
K
V
GT
L
PSHLA
A
LM
Q
T
NIN
V
Q
T
L
LT
E
A
I
L
TENRDR
V
YH
A
AM
MD
P
HTA
A
V
L
G
IDE
I
Y
AL
V
D
D
LI
A
AH
GD
WLP
GW
fig|637388.3.peg.2359
Escherichia coli O157:H7 str. FRIK2000 (1-448/451)
M
MSA
P
K
IT
F
IG
A
GST
I
FV
KN
ILG
D
V
FHREA
L
K
TAH
I
A
L
M
D
I
D
PT
R
LEESH
I
--V
V
R
K
L
MD
S
AG
ASG
K
ITC
H
T
Q
Q
K
EAL
Q
DADFV
VVAF
QI
G
G
Y
A
P
C
TVT
D
F
E
VCK
RHG
-
L
E
Q
TIAD
T
L
GPGGI
MR
A
LRTIP
H
L
W
QI
C
E
DM
T
E
V
CP
D
A
T
MLNY
V
NP
M
AM
N
T
W
A
M
Y
A
RY
P
HI
K
Q
V
GLCH
S
VQ
G
TAEE
L
A
RD
L
N
I
-
D
PAT
LR
Y
R
CA
G
I
NHM
AFYLE
L
E
R
KTAD
G
S
YV
N
L
Y
PELL
--
-
-
--------------
A
AYDA
GQA
PK
PN
I
HG-
-----------
--
NT
RC
Q
N
IV
R
Y
E
M
F
K
K
L
G
YFVT
E
SS
EH
F-
A
EYTPW
F
I
K
PG
RED
L
I
E
R
YK
V
P
LDEYPKRCVE
Q
L
ANWH
KELE
EYKN
A
SRI
D
I
KPSREY
A
S
TI
M
NAI
W
T
--------
G
E
P
S
VI
Y
G
N
----------------
V
R
N
D
G
L
IDN
L
P
QGCC
VE
V
A
C
L
V
D
A
NG
IQ
P
T
-
----
K
V
GT
L
PSHLA
A
LM
Q
T
NIN
V
Q
T
L
LT
E
A
I
L
TENRDR
V
YH
A
AM
MD
P
HTA
A
V
L
G
IDE
I
Y
AL
V
D
D
LI
A
AH
GD
WLP
GW
fig|570506.3.peg.1364
Escherichia coli O157:H7 str. FRIK966 (1-448/451)
M
MSA
P
K
IT
F
IG
A
GST
I
FV
KN
ILG
D
V
FHREA
L
K
TAH
I
A
L
M
D
I
D
PT
R
LEESH
I
--V
V
R
K
L
MD
S
AG
ASG
K
ITC
H
T
Q
Q
K
EAL
Q
DADFV
VVAF
QI
G
G
Y
A
P
C
TVT
D
F
E
VCK
RHG
-
L
E
Q
TIAD
T
L
GPGGI
MR
A
LRTIP
H
L
W
QI
C
E
DM
T
E
V
CP
D
A
T
MLNY
V
NP
M
AM
N
T
W
A
M
Y
A
RY
P
HI
K
Q
V
GLCH
S
VQ
G
TAEE
L
A
RD
L
N
I
-
D
PAT
LR
Y
R
CA
G
I
NHM
AFYLE
L
E
R
KTAD
G
S
YV
N
L
Y
PELL
--
-
-
--------------
A
AYDA
GQA
PK
PN
I
HG-
-----------
--
NT
RC
Q
N
IV
R
Y
E
M
F
K
K
L
G
YFVT
E
SS
EH
F-
A
EYTPW
F
I
K
PG
RED
L
I
E
R
YK
V
P
LDEYPKRCVE
Q
L
ANWH
KELE
EYKN
A
SRI
D
I
KPSREY
A
S
TI
M
NAI
W
T
--------
G
E
P
S
VI
Y
G
N
----------------
V
R
N
D
G
L
IDN
L
P
QGCC
VE
V
A
C
L
V
D
A
NG
IQ
P
T
-
----
K
V
GT
L
PSHLA
A
LM
Q
T
NIN
V
Q
T
L
LT
E
A
I
L
TENRDR
V
YH
A
AM
MD
P
HTA
A
V
L
G
IDE
I
Y
AL
V
D
D
LI
A
AH
GD
WLP
GW
fig|386585.9.peg.5331
Escherichia coli O157:H7 str. Sakai (1-448/451)
M
MSA
P
K
IT
F
IG
A
GST
I
FV
KN
ILG
D
V
FHREA
L
K
TAH
I
A
L
M
D
I
D
PT
R
LEESH
I
--V
V
R
K
L
MD
S
AG
ASG
K
ITC
H
T
Q
Q
K
EAL
Q
DADFV
VVAF
QI
G
G
Y
A
P
C
TVT
D
F
E
VCK
RHG
-
L
E
Q
TIAD
T
L
GPGGI
MR
A
LRTIP
H
L
W
QI
C
E
DM
T
E
V
CP
D
A
T
MLNY
V
NP
M
AM
N
T
W
A
M
Y
A
RY
P
HI
K
Q
V
GLCH
S
VQ
G
TAEE
L
A
RD
L
N
I
-
D
PAT
LR
Y
R
CA
G
I
NHM
AFYLE
L
E
R
KTAD
G
S
YV
N
L
Y
PELL
--
-
-
--------------
A
AYDA
GQA
PK
PN
I
HG-
-----------
--
NT
RC
Q
N
IV
R
Y
E
M
F
K
K
L
G
YFVT
E
SS
EH
F-
A
EYTPW
F
I
K
PG
RED
L
I
E
R
YK
V
P
LDEYPKRCVE
Q
L
ANWH
KELE
EYKN
A
SRI
D
I
KPSREY
A
S
TI
M
NAI
W
T
--------
G
E
P
S
VI
Y
G
N
----------------
V
R
N
D
G
L
IDN
L
P
QGCC
VE
V
A
C
L
V
D
A
NG
IQ
P
T
-
----
K
V
GT
L
PSHLA
A
LM
Q
T
NIN
V
Q
T
L
LT
E
A
I
L
TENRDR
V
YH
A
AM
MD
P
HTA
A
V
L
G
IDE
I
Y
AL
V
D
D
LI
A
AH
GD
WLP
GW
fig|544404.4.peg.5285
Escherichia coli O157:H7 str. TW14359 (1-448/451)
M
MSA
P
K
IT
F
IG
A
GST
I
FV
KN
ILG
D
V
FHREA
L
K
TAH
I
A
L
M
D
I
D
PT
R
LEESH
I
--V
V
R
K
L
MD
S
AG
ASG
K
ITC
H
T
Q
Q
K
EAL
Q
DADFV
VVAF
QI
G
G
Y
A
P
C
TVT
D
F
E
VCK
RHG
-
L
E
Q
TIAD
T
L
GPGGI
MR
A
LRTIP
H
L
W
QI
C
E
DM
T
E
V
CP
D
A
T
MLNY
V
NP
M
AM
N
T
W
A
M
Y
A
RY
P
HI
K
Q
V
GLCH
S
VQ
G
TAEE
L
A
RD
L
N
I
-
D
PAT
LR
Y
R
CA
G
I
NHM
AFYLE
L
E
R
KTAD
G
S
YV
N
L
Y
PELL
--
-
-
--------------
A
AYDA
GQA
PK
PN
I
HG-
-----------
--
NT
RC
Q
N
IV
R
Y
E
M
F
K
K
L
G
YFVT
E
SS
EH
F-
A
EYTPW
F
I
K
PG
RED
L
I
E
R
YK
V
P
LDEYPKRCVE
Q
L
ANWH
KELE
EYKN
A
SRI
D
I
KPSREY
A
S
TI
M
NAI
W
T
--------
G
E
P
S
VI
Y
G
N
----------------
V
R
N
D
G
L
IDN
L
P
QGCC
VE
V
A
C
L
V
D
A
NG
IQ
P
T
-
----
K
V
GT
L
PSHLA
A
LM
Q
T
NIN
V
Q
T
L
LT
E
A
I
L
TENRDR
V
YH
A
AM
MD
P
HTA
A
V
L
G
IDE
I
Y
AL
V
D
D
LI
A
AH
GD
WLP
GW
fig|502346.5.peg.1538
Escherichia coli O157:H7 str. TW14588 (1-448/451)
M
MSA
P
K
IT
F
IG
A
GST
I
FV
KN
ILG
D
V
FHREA
L
K
TAH
I
A
L
M
D
I
D
PT
R
LEESH
I
--V
V
R
K
L
MD
S
AG
ASG
K
ITC
H
T
Q
Q
K
EAL
Q
DADFV
VVAF
QI
G
G
Y
A
P
C
TVT
D
F
E
VCK
RHG
-
L
E
Q
TIAD
T
L
GPGGI
MR
A
LRTIP
H
L
W
QI
C
E
DM
T
E
V
CP
D
A
T
MLNY
V
NP
M
AM
N
T
W
A
M
Y
A
RY
P
HI
K
Q
V
GLCH
S
VQ
G
TAEE
L
A
RD
L
N
I
-
D
PAT
LR
Y
R
CA
G
I
NHM
AFYLE
L
E
R
KTAD
G
S
YV
N
L
Y
PELL
--
-
-
--------------
A
AYDA
GQA
PK
PN
I
HG-
-----------
--
NT
RC
Q
N
IV
R
Y
E
M
F
K
K
L
G
YFVT
E
SS
EH
F-
A
EYTPW
F
I
K
PG
RED
L
I
E
R
YK
V
P
LDEYPKRCVE
Q
L
ANWH
KELE
EYKN
A
SRI
D
I
KPSREY
A
S
TI
M
NAI
W
T
--------
G
E
P
S
VI
Y
G
N
----------------
V
R
N
D
G
L
IDN
L
P
QGCC
VE
V
A
C
L
V
D
A
NG
IQ
P
T
-
----
K
V
GT
L
PSHLA
A
LM
Q
T
NIN
V
Q
T
L
LT
E
A
I
L
TENRDR
V
YH
A
AM
MD
P
HTA
A
V
L
G
IDE
I
Y
AL
V
D
D
LI
A
AH
GD
WLP
GW
fig|439855.10.peg.4697
Escherichia coli SMS-3-5 (1-448/451)
M
MSA
P
K
IT
F
IG
A
GST
I
FV
KN
ILG
D
V
FHREA
L
K
TAH
I
A
L
M
D
I
D
PT
R
LEESH
I
--V
V
R
K
L
MD
S
AG
ASG
K
ITC
H
T
Q
Q
K
EAL
Q
DADFV
VVAF
QI
G
G
Y
E
P
C
TVT
D
F
E
VCK
RHG
-
L
E
Q
TIAD
T
L
GPGGI
MR
A
LRTIP
H
L
W
QI
C
E
DM
T
E
V
CP
D
A
T
MLNY
V
NP
M
AM
N
T
W
A
M
Y
A
RY
P
HI
K
Q
V
GLCH
S
VQ
G
TAEE
L
A
RD
L
N
I
-
D
PAT
LR
Y
R
CA
G
I
NHM
AFYLE
L
E
R
KTAD
G
S
YV
N
L
Y
PELL
--
-
-
--------------
A
AYDA
GQA
PK
PN
I
HG-
-----------
--
NT
RC
Q
N
IV
R
Y
E
M
F
K
K
L
G
YFVT
E
SS
EH
F-
A
EYTPW
F
I
K
PG
RED
L
I
E
R
YK
V
P
LDEYPKRCVE
Q
L
ANWH
KELE
EYKN
A
SRI
D
I
KPSREY
A
S
TI
M
NAI
W
T
--------
G
E
P
S
VI
Y
G
N
----------------
V
R
N
D
G
L
IDN
L
P
QGCC
VE
V
A
C
L
V
D
A
NG
IQ
P
T
-
----
K
V
GT
L
PSHLA
A
LM
Q
T
NIN
V
Q
T
L
LT
E
A
I
L
TENRDR
V
YH
A
AM
MD
P
HTA
A
V
L
G
IDE
I
Y
AL
V
D
D
LI
A
AH
GD
WLP
GW
fig|566546.3.peg.2190
Escherichia coli W (6-448/451)
K
IT
F
IG
A
GST
I
FV
KN
ILG
D
V
FHREA
L
K
TAH
I
A
L
M
D
I
D
PT
R
LEESH
I
--V
V
R
K
L
MD
S
AG
ASG
K
ITC
H
T
Q
Q
K
EAL
Q
DADFV
VVAF
QI
G
G
Y
E
P
C
TVT
D
F
E
VCK
RHG
-
L
E
Q
TIAD
T
L
GPGGI
MR
A
LRTIP
H
L
W
QI
C
E
DM
T
E
V
CP
D
A
T
MLNY
V
NP
M
AM
N
T
W
A
M
Y
A
RY
P
HI
K
Q
V
GLCH
S
VQ
G
TAEE
L
A
RD
L
N
I
-
D
PAT
LR
Y
R
CA
G
I
NHM
AFYLE
L
E
C
KTAD
G
S
YV
N
L
Y
PELL
--
-
-
--------------
A
AYDA
GQA
PK
PN
I
HG-
-----------
--
NT
RC
Q
N
IV
R
Y
E
M
F
K
K
L
G
YFVT
E
SS
EH
F-
A
EYTPW
F
I
K
PG
RED
L
I
E
R
YK
V
P
LDEYPKRCVE
Q
L
ANWH
KELE
EYKN
A
SRI
D
I
KPSREY
A
S
TI
M
NAI
W
T
--------
G
E
P
S
VI
Y
G
N
----------------
V
R
N
D
G
L
IDN
L
P
QGCC
VE
V
A
C
L
V
D
A
NG
IQ
P
T
-
----
K
V
GT
L
PSHLA
A
LM
Q
T
NIN
V
Q
T
L
LT
E
A
I
L
TENRDR
V
YH
A
AM
MD
P
HTA
A
V
L
G
IDE
I
Y
AL
V
D
D
LI
A
AH
GD
WLP
GW
fig|566546.4.peg.4415
Escherichia coli W (6-448/451)
K
IT
F
IG
A
GST
I
FV
KN
ILG
D
V
FHREA
L
K
TAH
I
A
L
M
D
I
D
PT
R
LEESH
I
--V
V
R
K
L
MD
S
AG
ASG
K
ITC
H
T
Q
Q
K
EAL
Q
DADFV
VVAF
QI
G
G
Y
E
P
C
TVT
D
F
E
VCK
RHG
-
L
E
Q
TIAD
T
L
GPGGI
MR
A
LRTIP
H
L
W
QI
C
E
DM
T
E
V
CP
D
A
T
MLNY
V
NP
M
AM
N
T
W
A
M
Y
A
RY
P
HI
K
Q
V
GLCH
S
VQ
G
TAEE
L
A
RD
L
N
I
-
D
PAT
LR
Y
R
CA
G
I
NHM
AFYLE
L
E
C
KTAD
G
S
YV
N
L
Y
PELL
--
-
-
--------------
A
AYDA
GQA
PK
PN
I
HG-
-----------
--
NT
RC
Q
N
IV
R
Y
E
M
F
K
K
L
G
YFVT
E
SS
EH
F-
A
EYTPW
F
I
K
PG
RED
L
I
E
R
YK
V
P
LDEYPKRCVE
Q
L
ANWH
KELE
EYKN
A
SRI
D
I
KPSREY
A
S
TI
M
NAI
W
T
--------
G
E
P
S
VI
Y
G
N
----------------
V
R
N
D
G
L
IDN
L
P
QGCC
VE
V
A
C
L
V
D
A
NG
IQ
P
T
-
----
K
V
GT
L
PSHLA
A
LM
Q
T
NIN
V
Q
T
L
LT
E
A
I
L
TENRDR
V
YH
A
AM
MD
P
HTA
A
V
L
G
IDE
I
Y
AL
V
D
D
LI
A
AH
GD
WLP
GW
fig|670897.3.peg.1436
Escherichia coli 2362-75 (1-448/451)
M
MSA
P
K
IT
F
IG
A
GST
I
FV
KN
ILG
D
V
FHREA
L
K
TAH
I
A
L
M
D
I
D
PT
R
LEESH
I
--V
V
R
K
L
MD
S
AG
ASG
K
ITC
H
T
Q
Q
K
EAL
Q
DADFV
VVAF
QI
G
G
Y
E
P
C
TVT
D
F
K
VCK
RHG
-
L
E
Q
TIAD
T
L
GPGGI
MR
A
LRTIP
H
L
W
QI
C
E
DM
T
E
V
CP
D
A
T
MLNY
V
NP
M
AM
N
T
W
A
M
Y
A
RY
P
HI
K
Q
V
GLCH
S
VQ
G
TAEE
L
A
RD
L
N
I
-
D
PAT
LR
Y
R
CA
G
I
NHM
AFYLE
L
E
R
KTAD
G
S
YV
N
L
Y
PELL
--
-
-
--------------
A
AYEA
GQA
PK
PN
I
HG-
-----------
--
NT
RC
Q
N
IV
R
Y
E
M
F
K
K
L
G
YFVT
E
SS
EH
F-
A
EYTPW
F
I
K
PG
RED
L
I
E
R
YK
V
P
LDEYPKRCVE
Q
L
ANWH
KELE
EYKN
A
SRI
D
I
KPSREY
A
S
TI
M
NAI
W
T
--------
G
E
P
S
VI
Y
G
N
----------------
V
R
N
D
G
L
IDN
L
P
QGCC
VE
V
A
C
L
V
D
A
NG
IQ
P
T
-
----
K
A
GT
L
PSHLA
A
LM
Q
T
NIN
V
Q
T
L
LT
E
A
I
L
TENRDR
V
YH
A
AM
MD
P
HTA
A
V
L
G
IDE
I
Y
AL
V
D
D
LI
A
AH
GD
WLP
GW
fig|216593.1.peg.3885
Escherichia coli E2348/69 (1-448/451)
M
MSA
P
K
IT
F
IG
A
GST
I
FV
KN
ILG
D
V
FHREA
L
K
TAH
I
A
L
M
D
I
D
PT
R
LEESH
I
--V
V
R
K
L
MD
S
AG
ASG
K
ITC
H
T
Q
Q
K
EAL
Q
DADFV
VVAF
QI
G
G
Y
E
P
C
TVT
D
F
K
VCK
RHG
-
L
E
Q
TIAD
T
L
GPGGI
MR
A
LRTIP
H
L
W
QI
C
E
DM
T
E
V
CP
D
A
T
MLNY
V
NP
M
AM
N
T
W
A
M
Y
A
RY
P
HI
K
Q
V
GLCH
S
VQ
G
TAEE
L
A
RD
L
N
I
-
D
PAT
LR
Y
R
CA
G
I
NHM
AFYLE
L
E
R
KTAD
G
S
YV
N
L
Y
PELL
--
-
-
--------------
A
AYEA
GQA
PK
PN
I
HG-
-----------
--
NT
RC
Q
N
IV
R
Y
E
M
F
K
K
L
G
YFVT
E
SS
EH
F-
A
EYTPW
F
I
K
PG
RED
L
I
E
R
YK
V
P
LDEYPKRCVE
Q
L
ANWH
KELE
EYKN
A
SRI
D
I
KPSREY
A
S
TI
M
NAI
W
T
--------
G
E
P
S
VI
Y
G
N
----------------
V
R
N
D
G
L
IDN
L
P
QGCC
VE
V
A
C
L
V
D
A
NG
IQ
P
T
-
----
K
A
GT
L
PSHLA
A
LM
Q
T
NIN
V
Q
T
L
LT
E
A
I
L
TENRDR
V
YH
A
AM
MD
P
HTA
A
V
L
G
IDE
I
Y
AL
V
D
D
LI
A
AH
GD
WLP
GW
fig|574521.7.peg.4548
Escherichia coli O127:H6 str. E2348/69 (1-448/451)
M
MSA
P
K
IT
F
IG
A
GST
I
FV
KN
ILG
D
V
FHREA
L
K
TAH
I
A
L
M
D
I
D
PT
R
LEESH
I
--V
V
R
K
L
MD
S
AG
ASG
K
ITC
H
T
Q
Q
K
EAL
Q
DADFV
VVAF
QI
G
G
Y
E
P
C
TVT
D
F
K
VCK
RHG
-
L
E
Q
TIAD
T
L
GPGGI
MR
A
LRTIP
H
L
W
QI
C
E
DM
T
E
V
CP
D
A
T
MLNY
V
NP
M
AM
N
T
W
A
M
Y
A
RY
P
HI
K
Q
V
GLCH
S
VQ
G
TAEE
L
A
RD
L
N
I
-
D
PAT
LR
Y
R
CA
G
I
NHM
AFYLE
L
E
R
KTAD
G
S
YV
N
L
Y
PELL
--
-
-
--------------
A
AYEA
GQA
PK
PN
I
HG-
-----------
--
NT
RC
Q
N
IV
R
Y
E
M
F
K
K
L
G
YFVT
E
SS
EH
F-
A
EYTPW
F
I
K
PG
RED
L
I
E
R
YK
V
P
LDEYPKRCVE
Q
L
ANWH
KELE
EYKN
A
SRI
D
I
KPSREY
A
S
TI
M
NAI
W
T
--------
G
E
P
S
VI
Y
G
N
----------------
V
R
N
D
G
L
IDN
L
P
QGCC
VE
V
A
C
L
V
D
A
NG
IQ
P
T
-
----
K
A
GT
L
PSHLA
A
LM
Q
T
NIN
V
Q
T
L
LT
E
A
I
L
TENRDR
V
YH
A
AM
MD
P
HTA
A
V
L
G
IDE
I
Y
AL
V
D
D
LI
A
AH
GD
WLP
GW
fig|340184.3.peg.713
Escherichia coli B7A (6-448/451)
K
IT
F
IG
A
GST
I
FV
KN
ILG
D
V
FHREA
L
K
TAH
I
A
L
M
D
I
A
PT
R
LEESH
I
--V
V
R
K
L
MD
S
AG
ASG
K
ITC
H
T
Q
Q
K
EAL
Q
DADFV
VVAF
QI
G
G
Y
E
P
C
TVT
D
F
E
VCK
RHG
-
L
E
Q
TIAD
T
L
GPGGI
MR
A
LRTIP
H
L
W
QI
C
E
DM
T
E
V
CP
D
A
T
MLNY
V
NP
M
AM
N
T
W
A
M
Y
A
RY
P
HI
K
Q
V
GLCH
S
VQ
G
TAEE
L
A
RD
L
N
I
-
D
PAT
LR
Y
R
CA
G
I
NHM
AFYLE
L
E
R
KTAD
G
S
YV
N
L
Y
PELL
--
-
-
--------------
A
AYEA
GQA
PK
PN
I
HG-
-----------
--
NT
RC
Q
N
IV
R
Y
E
M
F
K
K
L
G
YFVT
E
SS
EH
F-
A
EYTPW
F
I
K
PG
RED
L
I
E
R
YK
V
P
LDEYPKRCVE
Q
L
ANWH
KELE
EYKN
A
SRI
D
I
KPSREY
A
S
TI
M
NAI
W
T
--------
G
E
P
S
VI
Y
G
N
----------------
V
R
N
D
G
L
IDN
L
P
QGCC
VE
V
A
C
L
V
D
A
NG
IQ
P
T
-
----
K
V
GT
L
PSHLA
A
LM
Q
T
NIN
V
Q
T
L
LT
E
A
I
L
TENRDR
V
YH
A
AM
MD
P
HTA
A
V
L
G
IDE
I
Y
AL
V
D
D
LI
A
AH
GD
WLP
GW
fig|340184.6.peg.745
Escherichia coli B7A (6-448/451)
K
IT
F
IG
A
GST
I
FV
KN
ILG
D
V
FHREA
L
K
TAH
I
A
L
M
D
I
A
PT
R
LEESH
I
--V
V
R
K
L
MD
S
AG
ASG
K
ITC
H
T
Q
Q
K
EAL
Q
DADFV
VVAF
QI
G
G
Y
E
P
C
TVT
D
F
E
VCK
RHG
-
L
E
Q
TIAD
T
L
GPGGI
MR
A
LRTIP
H
L
W
QI
C
E
DM
T
E
V
CP
D
A
T
MLNY
V
NP
M
AM
N
T
W
A
M
Y
A
RY
P
HI
K
Q
V
GLCH
S
VQ
G
TAEE
L
A
RD
L
N
I
-
D
PAT
LR
Y
R
CA
G
I
NHM
AFYLE
L
E
R
KTAD
G
S
YV
N
L
Y
PELL
--
-
-
--------------
A
AYEA
GQA
PK
PN
I
HG-
-----------
--
NT
RC
Q
N
IV
R
Y
E
M
F
K
K
L
G
YFVT
E
SS
EH
F-
A
EYTPW
F
I
K
PG
RED
L
I
E
R
YK
V
P
LDEYPKRCVE
Q
L
ANWH
KELE
EYKN
A
SRI
D
I
KPSREY
A
S
TI
M
NAI
W
T
--------
G
E
P
S
VI
Y
G
N
----------------
V
R
N
D
G
L
IDN
L
P
QGCC
VE
V
A
C
L
V
D
A
NG
IQ
P
T
-
----
K
V
GT
L
PSHLA
A
LM
Q
T
NIN
V
Q
T
L
LT
E
A
I
L
TENRDR
V
YH
A
AM
MD
P
HTA
A
V
L
G
IDE
I
Y
AL
V
D
D
LI
A
AH
GD
WLP
GW
fig|670888.3.peg.4617
Escherichia coli 1827-70 (1-448/451)
M
MSA
P
K
IT
F
IG
A
GST
I
FV
KN
ILG
D
V
FHREA
L
K
TAH
I
A
L
M
D
I
D
PT
R
LEESH
I
--V
V
R
K
L
MD
S
AG
ASG
K
ITC
H
T
Q
Q
K
EAL
E
DADFV
VVAF
QI
G
G
Y
E
P
C
TVT
D
F
E
VCK
RHG
-
L
E
Q
TIAD
T
L
GPGGI
MR
A
LRTIP
H
L
W
QI
C
E
DM
T
E
V
CP
D
A
T
MLNY
V
NP
M
AM
N
T
W
A
M
Y
A
RY
P
HI
K
Q
V
GLCH
S
VQ
G
TAEE
L
A
RD
L
N
I
-
D
PAT
LR
Y
R
CA
G
I
NHM
AFYLE
L
E
R
KTAD
G
S
YV
N
L
Y
PELL
--
-
-
--------------
A
AYEA
GQA
PK
PN
I
HG-
-----------
--
NT
RC
Q
N
IV
R
Y
E
M
F
K
K
L
G
YFVT
E
SS
EH
F-
A
EYTPW
F
I
K
PG
RED
L
I
E
R
YK
V
P
LDEYPKRCVE
Q
L
ANWH
KELE
EYKK
A
SRI
D
I
KPSREY
A
S
TI
M
NAI
W
T
--------
G
E
P
S
VI
Y
G
N
----------------
V
R
N
D
G
L
IDN
L
P
QGCC
VE
V
A
C
L
V
D
A
NG
IQ
P
T
-
----
K
V
GT
L
PSHLA
A
LM
Q
T
NIN
V
Q
T
L
LT
E
A
I
L
TENRDR
V
YH
A
AM
MD
P
HTA
A
V
L
G
IDE
I
Y
AL
V
D
D
LI
A
AH
GD
WLP
GW
fig|595496.3.peg.4194
Escherichia coli BW2952 (1-448/451)
M
MSA
P
K
IT
F
IG
A
GST
I
FV
KN
ILG
D
V
FHREA
L
K
TAH
I
A
L
M
D
I
D
PT
R
LEESH
I
--V
V
R
K
L
MD
S
AG
ASG
K
ITC
H
T
Q
Q
K
EAL
E
DADFV
VVAF
QI
G
G
Y
E
P
C
TVT
D
F
E
VCK
RHG
-
L
E
Q
TIAD
T
L
GPGGI
MR
A
LRTIP
H
L
W
QI
C
E
DM
T
E
V
CP
D
A
T
MLNY
V
NP
M
AM
N
T
W
A
M
Y
A
RY
P
HI
K
Q
V
GLCH
S
VQ
G
TAEE
L
A
RD
L
N
I
-
D
PAT
LR
Y
R
CA
G
I
NHM
AFYLE
L
E
R
KTAD
G
S
YV
N
L
Y
PELL
--
-
-
--------------
A
AYEA
GQA
PK
PN
I
HG-
-----------
--
NT
RC
Q
N
IV
R
Y
E
M
F
K
K
L
G
YFVT
E
SS
EH
F-
A
EYTPW
F
I
K
PG
RED
L
I
E
R
YK
V
P
LDEYPKRCVE
Q
L
ANWH
KELE
EYKK
A
SRI
D
I
KPSREY
A
S
TI
M
NAI
W
T
--------
G
E
P
S
VI
Y
G
N
----------------
V
R
N
D
G
L
IDN
L
P
QGCC
VE
V
A
C
L
V
D
A
NG
IQ
P
T
-
----
K
V
GT
L
PSHLA
A
LM
Q
T
NIN
V
Q
T
L
LT
E
A
I
L
TENRDR
V
YH
A
AM
MD
P
HTA
A
V
L
G
IDE
I
Y
AL
V
D
D
LI
A
AH
GD
WLP
GW
fig|536056.3.peg.4112
Escherichia coli DH1 (1-448/451)
M
MSA
P
K
IT
F
IG
A
GST
I
FV
KN
ILG
D
V
FHREA
L
K
TAH
I
A
L
M
D
I
D
PT
R
LEESH
I
--V
V
R
K
L
MD
S
AG
ASG
K
ITC
H
T
Q
Q
K
EAL
E
DADFV
VVAF
QI
G
G
Y
E
P
C
TVT
D
F
E
VCK
RHG
-
L
E
Q
TIAD
T
L
GPGGI
MR
A
LRTIP
H
L
W
QI
C
E
DM
T
E
V
CP
D
A
T
MLNY
V
NP
M
AM
N
T
W
A
M
Y
A
RY
P
HI
K
Q
V
GLCH
S
VQ
G
TAEE
L
A
RD
L
N
I
-
D
PAT
LR
Y
R
CA
G
I
NHM
AFYLE
L
E
R
KTAD
G
S
YV
N
L
Y
PELL
--
-
-
--------------
A
AYEA
GQA
PK
PN
I
HG-
-----------
--
NT
RC
Q
N
IV
R
Y
E
M
F
K
K
L
G
YFVT
E
SS
EH
F-
A
EYTPW
F
I
K
PG
RED
L
I
E
R
YK
V
P
LDEYPKRCVE
Q
L
ANWH
KELE
EYKK
A
SRI
D
I
KPSREY
A
S
TI
M
NAI
W
T
--------
G
E
P
S
VI
Y
G
N
----------------
V
R
N
D
G
L
IDN
L
P
QGCC
VE
V
A
C
L
V
D
A
NG
IQ
P
T
-
----
K
V
GT
L
PSHLA
A
LM
Q
T
NIN
V
Q
T
L
LT
E
A
I
L
TENRDR
V
YH
A
AM
MD
P
HTA
A
V
L
G
IDE
I
Y
AL
V
D
D
LI
A
AH
GD
WLP
GW
fig|316401.4.peg.5031
Escherichia coli ETEC H10407 (1-448/451)
M
MSA
P
K
IT
F
IG
A
GST
I
FV
KN
ILG
D
V
FHREA
L
K
TAH
I
A
L
M
D
I
D
PT
R
LEESH
I
--V
V
R
K
L
MD
S
AG
ASG
K
ITC
H
T
Q
Q
K
EAL
E
DADFV
VVAF
QI
G
G
Y
E
P
C
TVT
D
F
E
VCK
RHG
-
L
E
Q
TIAD
T
L
GPGGI
MR
A
LRTIP
H
L
W
QI
C
E
DM
T
E
V
CP
D
A
T
MLNY
V
NP
M
AM
N
T
W
A
M
Y
A
RY
P
HI
K
Q
V
GLCH
S
VQ
G
TAEE
L
A
RD
L
N
I
-
D
PAT
LR
Y
R
CA
G
I
NHM
AFYLE
L
E
R
KTAD
G
S
YV
N
L
Y
PELL
--
-
-
--------------
A
AYEA
GQA
PK
PN
I
HG-
-----------
--
NT
RC
Q
N
IV
R
Y
E
M
F
K
K
L
G
YFVT
E
SS
EH
F-
A
EYTPW
F
I
K
PG
RED
L
I
E
R
YK
V
P
LDEYPKRCVE
Q
L
ANWH
KELE
EYKK
A
SRI
D
I
KPSREY
A
S
TI
M
NAI
W
T
--------
G
E
P
S
VI
Y
G
N
----------------
V
R
N
D
G
L
IDN
L
P
QGCC
VE
V
A
C
L
V
D
A
NG
IQ
P
T
-
----
K
V
GT
L
PSHLA
A
LM
Q
T
NIN
V
Q
T
L
LT
E
A
I
L
TENRDR
V
YH
A
AM
MD
P
HTA
A
V
L
G
IDE
I
Y
AL
V
D
D
LI
A
AH
GD
WLP
GW
fig|656414.3.peg.4679
Escherichia coli H736 (1-448/451)
M
MSA
P
K
IT
F
IG
A
GST
I
FV
KN
ILG
D
V
FHREA
L
K
TAH
I
A
L
M
D
I
D
PT
R
LEESH
I
--V
V
R
K
L
MD
S
AG
ASG
K
ITC
H
T
Q
Q
K
EAL
E
DADFV
VVAF
QI
G
G
Y
E
P
C
TVT
D
F
E
VCK
RHG
-
L
E
Q
TIAD
T
L
GPGGI
MR
A
LRTIP
H
L
W
QI
C
E
DM
T
E
V
CP
D
A
T
MLNY
V
NP
M
AM
N
T
W
A
M
Y
A
RY
P
HI
K
Q
V
GLCH
S
VQ
G
TAEE
L
A
RD
L
N
I
-
D
PAT
LR
Y
R
CA
G
I
NHM
AFYLE
L
E
R
KTAD
G
S
YV
N
L
Y
PELL
--
-
-
--------------
A
AYEA
GQA
PK
PN
I
HG-
-----------
--
NT
RC
Q
N
IV
R
Y
E
M
F
K
K
L
G
YFVT
E
SS
EH
F-
A
EYTPW
F
I
K
PG
RED
L
I
E
R
YK
V
P
LDEYPKRCVE
Q
L
ANWH
KELE
EYKK
A
SRI
D
I
KPSREY
A
S
TI
M
NAI
W
T
--------
G
E
P
S
VI
Y
G
N
----------------
V
R
N
D
G
L
IDN
L
P
QGCC
VE
V
A
C
L
V
D
A
NG
IQ
P
T
-
----
K
V
GT
L
PSHLA
A
LM
Q
T
NIN
V
Q
T
L
LT
E
A
I
L
TENRDR
V
YH
A
AM
MD
P
HTA
A
V
L
G
IDE
I
Y
AL
V
D
D
LI
A
AH
GD
WLP
GW
fig|83333.1.peg.4031
Escherichia coli K12 (1-448/451)
M
MSA
P
K
IT
F
IG
A
GST
I
FV
KN
ILG
D
V
FHREA
L
K
TAH
I
A
L
M
D
I
D
PT
R
LEESH
I
--V
V
R
K
L
MD
S
AG
ASG
K
ITC
H
T
Q
Q
K
EAL
E
DADFV
VVAF
QI
G
G
Y
E
P
C
TVT
D
F
E
VCK
RHG
-
L
E
Q
TIAD
T
L
GPGGI
MR
A
LRTIP
H
L
W
QI
C
E
DM
T
E
V
CP
D
A
T
MLNY
V
NP
M
AM
N
T
W
A
M
Y
A
RY
P
HI
K
Q
V
GLCH
S
VQ
G
TAEE
L
A
RD
L
N
I
-
D
PAT
LR
Y
R
CA
G
I
NHM
AFYLE
L
E
R
KTAD
G
S
YV
N
L
Y
PELL
--
-
-
--------------
A
AYEA
GQA
PK
PN
I
HG-
-----------
--
NT
RC
Q
N
IV
R
Y
E
M
F
K
K
L
G
YFVT
E
SS
EH
F-
A
EYTPW
F
I
K
PG
RED
L
I
E
R
YK
V
P
LDEYPKRCVE
Q
L
ANWH
KELE
EYKK
A
SRI
D
I
KPSREY
A
S
TI
M
NAI
W
T
--------
G
E
P
S
VI
Y
G
N
----------------
V
R
N
D
G
L
IDN
L
P
QGCC
VE
V
A
C
L
V
D
A
NG
IQ
P
T
-
----
K
V
GT
L
PSHLA
A
LM
Q
T
NIN
V
Q
T
L
LT
E
A
I
L
TENRDR
V
YH
A
AM
MD
P
HTA
A
V
L
G
IDE
I
Y
AL
V
D
D
LI
A
AH
GD
WLP
GW
fig|595495.4.peg.4120
Escherichia coli KO11 (1-448/451)
M
MSA
P
K
IT
F
IG
A
GST
I
FV
KN
ILG
D
V
FHREA
L
K
TAH
I
A
L
M
D
I
D
PT
R
LEESH
I
--V
V
R
K
L
MD
S
AG
ASG
K
ITC
H
T
Q
Q
K
EAL
E
DADFV
VVAF
QI
G
G
Y
E
P
C
TVT
D
F
E
VCK
RHG
-
L
E
Q
TIAD
T
L
GPGGI
MR
A
LRTIP
H
L
W
QI
C
E
DM
T
E
V
CP
D
A
T
MLNY
V
NP
M
AM
N
T
W
A
M
Y
A
RY
P
HI
K
Q
V
GLCH
S
VQ
G
TAEE
L
A
RD
L
N
I
-
D
PAT
LR
Y
R
CA
G
I
NHM
AFYLE
L
E
R
KTAD
G
S
YV
N
L
Y
PELL
--
-
-
--------------
A
AYEA
GQA
PK
PN
I
HG-
-----------
--
NT
RC
Q
N
IV
R
Y
E
M
F
K
K
L
G
YFVT
E
SS
EH
F-
A
EYTPW
F
I
K
PG
RED
L
I
E
R
YK
V
P
LDEYPKRCVE
Q
L
ANWH
KELE
EYKK
A
SRI
D
I
KPSREY
A
S
TI
M
NAI
W
T
--------
G
E
P
S
VI
Y
G
N
----------------
V
R
N
D
G
L
IDN
L
P
QGCC
VE
V
A
C
L
V
D
A
NG
IQ
P
T
-
----
K
V
GT
L
PSHLA
A
LM
Q
T
NIN
V
Q
T
L
LT
E
A
I
L
TENRDR
V
YH
A
AM
MD
P
HTA
A
V
L
G
IDE
I
Y
AL
V
D
D
LI
A
AH
GD
WLP
GW
fig|749538.3.peg.1247
Escherichia coli MS 116-1 (1-448/451)
M
MSA
P
K
IT
F
IG
A
GST
I
FV
KN
ILG
D
V
FHREA
L
K
TAH
I
A
L
M
D
I
D
PT
R
LEESH
I
--V
V
R
K
L
MD
S
AG
ASG
K
ITC
H
T
Q
Q
K
EAL
E
DADFV
VVAF
QI
G
G
Y
E
P
C
TVT
D
F
E
VCK
RHG
-
L
E
Q
TIAD
T
L
GPGGI
MR
A
LRTIP
H
L
W
QI
C
E
DM
T
E
V
CP
D
A
T
MLNY
V
NP
M
AM
N
T
W
A
M
Y
A
RY
P
HI
K
Q
V
GLCH
S
VQ
G
TAEE
L
A
RD
L
N
I
-
D
PAT
LR
Y
R
CA
G
I
NHM
AFYLE
L
E
R
KTAD
G
S
YV
N
L
Y
PELL
--
-
-
--------------
A
AYEA
GQA
PK
PN
I
HG-
-----------
--
NT
RC
Q
N
IV
R
Y
E
M
F
K
K
L
G
YFVT
E
SS
EH
F-
A
EYTPW
F
I
K
PG
RED
L
I
E
R
YK
V
P
LDEYPKRCVE
Q
L
ANWH
KELE
EYKK
A
SRI
D
I
KPSREY
A
S
TI
M
NAI
W
T
--------
G
E
P
S
VI
Y
G
N
----------------
V
R
N
D
G
L
IDN
L
P
QGCC
VE
V
A
C
L
V
D
A
NG
IQ
P
T
-
----
K
V
GT
L
PSHLA
A
LM
Q
T
NIN
V
Q
T
L
LT
E
A
I
L
TENRDR
V
YH
A
AM
MD
P
HTA
A
V
L
G
IDE
I
Y
AL
V
D
D
LI
A
AH
GD
WLP
GW
fig|749540.3.peg.1307
Escherichia coli MS 146-1 (1-448/451)
M
MSA
P
K
IT
F
IG
A
GST
I
FV
KN
ILG
D
V
FHREA
L
K
TAH
I
A
L
M
D
I
D
PT
R
LEESH
I
--V
V
R
K
L
MD
S
AG
ASG
K
ITC
H
T
Q
Q
K
EAL
E
DADFV
VVAF
QI
G
G
Y
E
P
C
TVT
D
F
E
VCK
RHG
-
L
E
Q
TIAD
T
L
GPGGI
MR
A
LRTIP
H
L
W
QI
C
E
DM
T
E
V
CP
D
A
T
MLNY
V
NP
M
AM
N
T
W
A
M
Y
A
RY
P
HI
K
Q
V
GLCH
S
VQ
G
TAEE
L
A
RD
L
N
I
-
D
PAT
LR
Y
R
CA
G
I
NHM
AFYLE
L
E
R
KTAD
G
S
YV
N
L
Y
PELL
--
-
-
--------------
A
AYEA
GQA
PK
PN
I
HG-
-----------
--
NT
RC
Q
N
IV
R
Y
E
M
F
K
K
L
G
YFVT
E
SS
EH
F-
A
EYTPW
F
I
K
PG
RED
L
I
E
R
YK
V
P
LDEYPKRCVE
Q
L
ANWH
KELE
EYKK
A
SRI
D
I
KPSREY
A
S
TI
M
NAI
W
T
--------
G
E
P
S
VI
Y
G
N
----------------
V
R
N
D
G
L
IDN
L
P
QGCC
VE
V
A
C
L
V
D
A
NG
IQ
P
T
-
----
K
V
GT
L
PSHLA
A
LM
Q
T
NIN
V
Q
T
L
LT
E
A
I
L
TENRDR
V
YH
A
AM
MD
P
HTA
A
V
L
G
IDE
I
Y
AL
V
D
D
LI
A
AH
GD
WLP
GW
fig|749544.3.peg.102
Escherichia coli MS 175-1 (1-448/451)
M
MSA
P
K
IT
F
IG
A
GST
I
FV
KN
ILG
D
V
FHREA
L
K
TAH
I
A
L
M
D
I
D
PT
R
LEESH
I
--V
V
R
K
L
MD
S
AG
ASG
K
ITC
H
T
Q
Q
K
EAL
E
DADFV
VVAF
QI
G
G
Y
E
P
C
TVT
D
F
E
VCK
RHG
-
L
E
Q
TIAD
T
L
GPGGI
MR
A
LRTIP
H
L
W
QI
C
E
DM
T
E
V
CP
D
A
T
MLNY
V
NP
M
AM
N
T
W
A
M
Y
A
RY
P
HI
K
Q
V
GLCH
S
VQ
G
TAEE
L
A
RD
L
N
I
-
D
PAT
LR
Y
R
CA
G
I
NHM
AFYLE
L
E
R
KTAD
G
S
YV
N
L
Y
PELL
--
-
-
--------------
A
AYEA
GQA
PK
PN
I
HG-
-----------
--
NT
RC
Q
N
IV
R
Y
E
M
F
K
K
L
G
YFVT
E
SS
EH
F-
A
EYTPW
F
I
K
PG
RED
L
I
E
R
YK
V
P
LDEYPKRCVE
Q
L
ANWH
KELE
EYKK
A
SRI
D
I
KPSREY
A
S
TI
M
NAI
W
T
--------
G
E
P
S
VI
Y
G
N
----------------
V
R
N
D
G
L
IDN
L
P
QGCC
VE
V
A
C
L
V
D
A
NG
IQ
P
T
-
----
K
V
GT
L
PSHLA
A
LM
Q
T
NIN
V
Q
T
L
LT
E
A
I
L
TENRDR
V
YH
A
AM
MD
P
HTA
A
V
L
G
IDE
I
Y
AL
V
D
D
LI
A
AH
GD
WLP
GW
fig|316407.3.peg.3956
Escherichia coli W3110 (1-448/451)
M
MSA
P
K
IT
F
IG
A
GST
I
FV
KN
ILG
D
V
FHREA
L
K
TAH
I
A
L
M
D
I
D
PT
R
LEESH
I
--V
V
R
K
L
MD
S
AG
ASG
K
ITC
H
T
Q
Q
K
EAL
E
DADFV
VVAF
QI
G
G
Y
E
P
C
TVT
D
F
E
VCK
RHG
-
L
E
Q
TIAD
T
L
GPGGI
MR
A
LRTIP
H
L
W
QI
C
E
DM
T
E
V
CP
D
A
T
MLNY
V
NP
M
AM
N
T
W
A
M
Y
A
RY
P
HI
K
Q
V
GLCH
S
VQ
G
TAEE
L
A
RD
L
N
I
-
D
PAT
LR
Y
R
CA
G
I
NHM
AFYLE
L
E
R
KTAD
G
S
YV
N
L
Y
PELL
--
-
-
--------------
A
AYEA
GQA
PK
PN
I
HG-
-----------
--
NT
RC
Q
N
IV
R
Y
E
M
F
K
K
L
G
YFVT
E
SS
EH
F-
A
EYTPW
F
I
K
PG
RED
L
I
E
R
YK
V
P
LDEYPKRCVE
Q
L
ANWH
KELE
EYKK
A
SRI
D
I
KPSREY
A
S
TI
M
NAI
W
T
--------
G
E
P
S
VI
Y
G
N
----------------
V
R
N
D
G
L
IDN
L
P
QGCC
VE
V
A
C
L
V
D
A
NG
IQ
P
T
-
----
K
V
GT
L
PSHLA
A
LM
Q
T
NIN
V
Q
T
L
LT
E
A
I
L
TENRDR
V
YH
A
AM
MD
P
HTA
A
V
L
G
IDE
I
Y
AL
V
D
D
LI
A
AH
GD
WLP
GW
fig|316385.5.peg.4264
Escherichia coli str. K-12 substr. DH10B (1-448/451)
M
MSA
P
K
IT
F
IG
A
GST
I
FV
KN
ILG
D
V
FHREA
L
K
TAH
I
A
L
M
D
I
D
PT
R
LEESH
I
--V
V
R
K
L
MD
S
AG
ASG
K
ITC
H
T
Q
Q
K
EAL
E
DADFV
VVAF
QI
G
G
Y
E
P
C
TVT
D
F
E
VCK
RHG
-
L
E
Q
TIAD
T
L
GPGGI
MR
A
LRTIP
H
L
W
QI
C
E
DM
T
E
V
CP
D
A
T
MLNY
V
NP
M
AM
N
T
W
A
M
Y
A
RY
P
HI
K
Q
V
GLCH
S
VQ
G
TAEE
L
A
RD
L
N
I
-
D
PAT
LR
Y
R
CA
G
I
NHM
AFYLE
L
E
R
KTAD
G
S
YV
N
L
Y
PELL
--
-
-
--------------
A
AYEA
GQA
PK
PN
I
HG-
-----------
--
NT
RC
Q
N
IV
R
Y
E
M
F
K
K
L
G
YFVT
E
SS
EH
F-
A
EYTPW
F
I
K
PG
RED
L
I
E
R
YK
V
P
LDEYPKRCVE
Q
L
ANWH
KELE
EYKK
A
SRI
D
I
KPSREY
A
S
TI
M
NAI
W
T
--------
G
E
P
S
VI
Y
G
N
----------------
V
R
N
D
G
L
IDN
L
P
QGCC
VE
V
A
C
L
V
D
A
NG
IQ
P
T
-
----
K
V
GT
L
PSHLA
A
LM
Q
T
NIN
V
Q
T
L
LT
E
A
I
L
TENRDR
V
YH
A
AM
MD
P
HTA
A
V
L
G
IDE
I
Y
AL
V
D
D
LI
A
AH
GD
WLP
GW
fig|316385.7.peg.4353
Escherichia coli str. K-12 substr. DH10B (1-448/451)
M
MSA
P
K
IT
F
IG
A
GST
I
FV
KN
ILG
D
V
FHREA
L
K
TAH
I
A
L
M
D
I
D
PT
R
LEESH
I
--V
V
R
K
L
MD
S
AG
ASG
K
ITC
H
T
Q
Q
K
EAL
E
DADFV
VVAF
QI
G
G
Y
E
P
C
TVT
D
F
E
VCK
RHG
-
L
E
Q
TIAD
T
L
GPGGI
MR
A
LRTIP
H
L
W
QI
C
E
DM
T
E
V
CP
D
A
T
MLNY
V
NP
M
AM
N
T
W
A
M
Y
A
RY
P
HI
K
Q
V
GLCH
S
VQ
G
TAEE
L
A
RD
L
N
I
-
D
PAT
LR
Y
R
CA
G
I
NHM
AFYLE
L
E
R
KTAD
G
S
YV
N
L
Y
PELL
--
-
-
--------------
A
AYEA
GQA
PK
PN
I
HG-
-----------
--
NT
RC
Q
N
IV
R
Y
E
M
F
K
K
L
G
YFVT
E
SS
EH
F-
A
EYTPW
F
I
K
PG
RED
L
I
E
R
YK
V
P
LDEYPKRCVE
Q
L
ANWH
KELE
EYKK
A
SRI
D
I
KPSREY
A
S
TI
M
NAI
W
T
--------
G
E
P
S
VI
Y
G
N
----------------
V
R
N
D
G
L
IDN
L
P
QGCC
VE
V
A
C
L
V
D
A
NG
IQ
P
T
-
----
K
V
GT
L
PSHLA
A
LM
Q
T
NIN
V
Q
T
L
LT
E
A
I
L
TENRDR
V
YH
A
AM
MD
P
HTA
A
V
L
G
IDE
I
Y
AL
V
D
D
LI
A
AH
GD
WLP
GW
fig|511145.12.peg.4250
Escherichia coli str. K-12 substr. MG1655 (1-448/451)
M
MSA
P
K
IT
F
IG
A
GST
I
FV
KN
ILG
D
V
FHREA
L
K
TAH
I
A
L
M
D
I
D
PT
R
LEESH
I
--V
V
R
K
L
MD
S
AG
ASG
K
ITC
H
T
Q
Q
K
EAL
E
DADFV
VVAF
QI
G
G
Y
E
P
C
TVT
D
F
E
VCK
RHG
-
L
E
Q
TIAD
T
L
GPGGI
MR
A
LRTIP
H
L
W
QI
C
E
DM
T
E
V
CP
D
A
T
MLNY
V
NP
M
AM
N
T
W
A
M
Y
A
RY
P
HI
K
Q
V
GLCH
S
VQ
G
TAEE
L
A
RD
L
N
I
-
D
PAT
LR
Y
R
CA
G
I
NHM
AFYLE
L
E
R
KTAD
G
S
YV
N
L
Y
PELL
--
-
-
--------------
A
AYEA
GQA
PK
PN
I
HG-
-----------
--
NT
RC
Q
N
IV
R
Y
E
M
F
K
K
L
G
YFVT
E
SS
EH
F-
A
EYTPW
F
I
K
PG
RED
L
I
E
R
YK
V
P
LDEYPKRCVE
Q
L
ANWH
KELE
EYKK
A
SRI
D
I
KPSREY
A
S
TI
M
NAI
W
T
--------
G
E
P
S
VI
Y
G
N
----------------
V
R
N
D
G
L
IDN
L
P
QGCC
VE
V
A
C
L
V
D
A
NG
IQ
P
T
-
----
K
V
GT
L
PSHLA
A
LM
Q
T
NIN
V
Q
T
L
LT
E
A
I
L
TENRDR
V
YH
A
AM
MD
P
HTA
A
V
L
G
IDE
I
Y
AL
V
D
D
LI
A
AH
GD
WLP
GW
fig|511145.6.peg.4229
Escherichia coli str. K-12 substr. MG1655 (1-448/451)
M
MSA
P
K
IT
F
IG
A
GST
I
FV
KN
ILG
D
V
FHREA
L
K
TAH
I
A
L
M
D
I
D
PT
R
LEESH
I
--V
V
R
K
L
MD
S
AG
ASG
K
ITC
H
T
Q
Q
K
EAL
E
DADFV
VVAF
QI
G
G
Y
E
P
C
TVT
D
F
E
VCK
RHG
-
L
E
Q
TIAD
T
L
GPGGI
MR
A
LRTIP
H
L
W
QI
C
E
DM
T
E
V
CP
D
A
T
MLNY
V
NP
M
AM
N
T
W
A
M
Y
A
RY
P
HI
K
Q
V
GLCH
S
VQ
G
TAEE
L
A
RD
L
N
I
-
D
PAT
LR
Y
R
CA
G
I
NHM
AFYLE
L
E
R
KTAD
G
S
YV
N
L
Y
PELL
--
-
-
--------------
A
AYEA
GQA
PK
PN
I
HG-
-----------
--
NT
RC
Q
N
IV
R
Y
E
M
F
K
K
L
G
YFVT
E
SS
EH
F-
A
EYTPW
F
I
K
PG
RED
L
I
E
R
YK
V
P
LDEYPKRCVE
Q
L
ANWH
KELE
EYKK
A
SRI
D
I
KPSREY
A
S
TI
M
NAI
W
T
--------
G
E
P
S
VI
Y
G
N
----------------
V
R
N
D
G
L
IDN
L
P
QGCC
VE
V
A
C
L
V
D
A
NG
IQ
P
T
-
----
K
V
GT
L
PSHLA
A
LM
Q
T
NIN
V
Q
T
L
LT
E
A
I
L
TENRDR
V
YH
A
AM
MD
P
HTA
A
V
L
G
IDE
I
Y
AL
V
D
D
LI
A
AH
GD
WLP
GW
fig|550672.3.peg.4198
Escherichia coli B088 (6-448/451)
K
IT
F
IG
A
GST
I
FV
KN
ILG
D
V
FHREA
L
K
TAH
I
A
L
M
D
I
D
PT
R
LEESH
I
--V
V
R
K
L
MD
S
AG
ASG
K
ITC
H
T
Q
Q
K
EAL
H
DADFV
VVAF
QI
G
G
Y
E
P
C
TVT
D
F
E
VCK
RHG
-
L
E
Q
TIAD
T
L
GPGGI
MR
A
LRTIP
H
L
W
QI
C
E
DM
T
E
V
CP
D
A
T
MLNY
V
NP
M
AM
N
T
W
A
M
Y
A
RY
P
HI
K
Q
V
GLCH
S
VQ
G
TAEE
L
A
RD
L
N
I
-
D
PAT
LR
Y
R
CA
G
I
NHM
AFYLE
L
E
R
KTAD
G
S
YV
N
L
Y
PELL
--
-
-
--------------
A
AYEA
GQA
PK
PN
I
HG-
-----------
--
NT
RC
Q
N
IV
R
Y
E
M
F
K
K
L
G
YFVT
E
SS
EH
F-
A
EYTPW
F
I
K
PG
RED
L
I
E
R
YK
V
P
LDEYPKRCVE
Q
L
ANWH
KELE
EYKN
A
SLI
D
I
KPSREY
A
S
TI
M
NAI
W
T
--------
G
E
P
S
VI
Y
G
N
----------------
V
R
N
D
G
L
IDN
L
P
QGCC
VE
V
A
C
L
V
D
A
NG
IQ
P
T
-
----
K
V
GT
L
PSHLA
A
LM
Q
T
NIN
V
Q
T
L
LT
E
A
I
L
TENRDR
V
YH
A
AM
MD
P
HTA
A
V
L
G
IDE
I
Y
AL
V
D
D
LI
A
AH
GD
WLP
GW
fig|431946.3.peg.4161
Escherichia coli SE15 (1-448/451)
M
MSA
P
K
IT
F
IG
A
GST
I
FV
KN
ILG
D
V
FHREA
L
K
TAH
I
A
L
M
D
I
D
PT
R
LEESH
I
--V
V
R
K
L
MD
S
AG
ASG
K
ITC
H
T
Q
Q
K
EAL
Q
DADFV
VVAF
QI
G
G
Y
E
P
C
TVT
D
F
E
VCK
RHG
-
L
E
Q
TIAD
T
L
GPGGI
MR
A
LRTIP
H
L
W
QI
C
E
DM
T
E
V
CP
D
A
T
MLNY
V
NP
M
AM
N
T
W
A
M
Y
A
RY
P
HI
K
Q
V
GLCH
S
VQ
G
TAEE
L
A
RD
L
N
I
-
D
PAT
LR
Y
R
CA
G
I
NHM
AFYLE
L
E
R
KTAD
G
S
YV
N
L
Y
PELL
--
-
-
--------------
A
AYEA
GQA
PK
PN
I
HG-
-----------
--
NT
RC
Q
N
IV
R
Y
E
M
F
K
K
L
G
YFVT
E
SS
EH
F-
A
EYTPW
F
I
K
PG
RED
L
I
E
R
YK
V
P
LDEYPKRCVE
Q
L
ANWH
KELE
EYKN
A
SRI
D
I
KPSREY
A
S
TI
M
NAI
W
T
--------
G
E
P
S
VI
Y
G
N
----------------
V
R
N
D
G
L
IDN
L
P
QGCC
VE
V
A
C
L
V
D
A
NG
IQ
P
T
-
----
K
A
GT
L
PSHLA
A
LM
Q
T
NIN
V
Q
T
L
LT
E
A
I
L
TENRDR
V
YH
A
AM
MD
P
HTA
A
V
L
G
IEE
I
Y
AL
V
D
D
LI
A
AH
GD
WLP
GW
fig|340186.3.peg.1045
Escherichia coli E110019 (6-448/451)
K
IT
F
IG
A
GST
I
FV
KN
ILG
D
V
FHREA
L
K
TAH
I
A
L
M
D
I
D
PT
R
LEESH
I
--V
V
R
K
L
MD
S
AG
ASG
K
ITC
H
T
Q
Q
K
EAL
H
DADFV
VVAF
QI
G
G
Y
E
P
C
TVT
D
F
E
VCK
RHG
-
L
E
Q
TIAD
T
L
GPGGI
MR
A
LRTIP
H
L
W
QI
C
E
DM
T
E
V
CP
D
A
T
MLNY
V
NP
M
AM
N
T
W
A
M
Y
A
RY
P
HI
K
Q
V
GLCH
S
VQ
G
TAEE
L
A
RD
L
N
I
-
D
PAT
LR
Y
R
CA
G
I
NHM
AFYLE
L
E
R
KTAD
G
S
YV
N
L
Y
PELL
--
-
-
--------------
A
AYEA
GQA
PK
PN
I
HG-
-----------
--
NT
RC
Q
N
IV
R
Y
E
M
F
K
K
L
G
YFVT
E
SS
EH
F-
A
EYTPW
F
I
K
PG
RED
L
I
E
R
YK
V
P
LDEYPKRCVE
Q
L
ANWH
KELE
EYKN
A
SRI
D
I
KPSREY
A
S
TI
M
NAI
W
T
--------
G
E
P
S
VI
Y
G
N
----------------
V
R
N
D
G
L
IDN
L
P
QGCC
VE
V
A
C
L
V
D
A
NG
IQ
P
T
-
----
K
V
GT
L
PSHLA
A
LM
Q
T
NIN
V
Q
T
L
LT
E
A
I
L
TENRDR
V
YH
A
AM
MD
P
HTA
A
V
L
G
IDE
I
Y
AL
V
D
D
LI
A
AH
GD
WLP
GW
fig|340186.5.peg.1086
Escherichia coli E110019 (6-448/451)
K
IT
F
IG
A
GST
I
FV
KN
ILG
D
V
FHREA
L
K
TAH
I
A
L
M
D
I
D
PT
R
LEESH
I
--V
V
R
K
L
MD
S
AG
ASG
K
ITC
H
T
Q
Q
K
EAL
H
DADFV
VVAF
QI
G
G
Y
E
P
C
TVT
D
F
E
VCK
RHG
-
L
E
Q
TIAD
T
L
GPGGI
MR
A
LRTIP
H
L
W
QI
C
E
DM
T
E
V
CP
D
A
T
MLNY
V
NP
M
AM
N
T
W
A
M
Y
A
RY
P
HI
K
Q
V
GLCH
S
VQ
G
TAEE
L
A
RD
L
N
I
-
D
PAT
LR
Y
R
CA
G
I
NHM
AFYLE
L
E
R
KTAD
G
S
YV
N
L
Y
PELL
--
-
-
--------------
A
AYEA
GQA
PK
PN
I
HG-
-----------
--
NT
RC
Q
N
IV
R
Y
E
M
F
K
K
L
G
YFVT
E
SS
EH
F-
A
EYTPW
F
I
K
PG
RED
L
I
E
R
YK
V
P
LDEYPKRCVE
Q
L
ANWH
KELE
EYKN
A
SRI
D
I
KPSREY
A
S
TI
M
NAI
W
T
--------
G
E
P
S
VI
Y
G
N
----------------
V
R
N
D
G
L
IDN
L
P
QGCC
VE
V
A
C
L
V
D
A
NG
IQ
P
T
-
----
K
V
GT
L
PSHLA
A
LM
Q
T
NIN
V
Q
T
L
LT
E
A
I
L
TENRDR
V
YH
A
AM
MD
P
HTA
A
V
L
G
IDE
I
Y
AL
V
D
D
LI
A
AH
GD
WLP
GW
fig|585396.4.peg.5194
Escherichia coli O111:H- str. 11128 (6-448/451)
K
IT
F
IG
A
GST
I
FV
KN
ILG
D
V
FHREA
L
K
TAH
I
A
L
M
D
I
D
PT
R
LEESH
I
--V
V
R
K
L
MD
S
AG
ASG
K
ITC
H
T
Q
Q
K
EAL
H
DADFV
VVAF
QI
G
G
Y
E
P
C
TVT
D
F
E
VCK
RHG
-
L
E
Q
TIAD
T
L
GPGGI
MR
A
LRTIP
H
L
W
QI
C
E
DM
T
E
V
CP
D
A
T
MLNY
V
NP
M
AM
N
T
W
A
M
Y
A
RY
P
HI
K
Q
V
GLCH
S
VQ
G
TAEE
L
A
RD
L
N
I
-
D
PAT
LR
Y
R
CA
G
I
NHM
AFYLE
L
E
R
KTAD
G
S
YV
N
L
Y
PELL
--
-
-
--------------
A
AYEA
GQA
PK
PN
I
HG-
-----------
--
NT
RC
Q
N
IV
R
Y
E
M
F
K
K
L
G
YFVT
E
SS
EH
F-
A
EYTPW
F
I
K
PG
RED
L
I
E
R
YK
V
P
LDEYPKRCVE
Q
L
ANWH
KELE
EYKN
A
SRI
D
I
KPSREY
A
S
TI
M
NAI
W
T
--------
G
E
P
S
VI
Y
G
N
----------------
V
R
N
D
G
L
IDN
L
P
QGCC
VE
V
A
C
L
V
D
A
NG
IQ
P
T
-
----
K
V
GT
L
PSHLA
A
LM
Q
T
NIN
V
Q
T
L
LT
E
A
I
L
TENRDR
V
YH
A
AM
MD
P
HTA
A
V
L
G
IDE
I
Y
AL
V
D
D
LI
A
AH
GD
WLP
GW
fig|573235.3.peg.5401
Escherichia coli O26:H11 str. 11368 (6-448/451)
K
IT
F
IG
A
GST
I
FV
KN
ILG
D
V
FHREA
L
K
TAH
I
A
L
M
D
I
D
PT
R
LEESH
I
--V
V
R
K
L
MD
S
AG
ASG
K
ITC
H
T
Q
Q
K
EAL
H
DADFV
VVAF
QI
G
G
Y
E
P
C
TVT
D
F
E
VCK
RHG
-
L
E
Q
TIAD
T
L
GPGGI
MR
A
LRTIP
H
L
W
QI
C
E
DM
T
E
V
CP
D
A
T
MLNY
V
NP
M
AM
N
T
W
A
M
Y
A
RY
P
HI
K
Q
V
GLCH
S
VQ
G
TAEE
L
A
RD
L
N
I
-
D
PAT
LR
Y
R
CA
G
I
NHM
AFYLE
L
E
R
KTAD
G
S
YV
N
L
Y
PELL
--
-
-
--------------
A
AYEA
GQA
PK
PN
I
HG-
-----------
--
NT
RC
Q
N
IV
R
Y
E
M
F
K
K
L
G
YFVT
E
SS
EH
F-
A
EYTPW
F
I
K
PG
RED
L
I
E
R
YK
V
P
LDEYPKRCVE
Q
L
ANWH
KELE
EYKN
A
SRI
D
I
KPSREY
A
S
TI
M
NAI
W
T
--------
G
E
P
S
VI
Y
G
N
----------------
V
R
N
D
G
L
IDN
L
P
QGCC
VE
V
A
C
L
V
D
A
NG
IQ
P
T
-
----
K
V
GT
L
PSHLA
A
LM
Q
T
NIN
V
Q
T
L
LT
E
A
I
L
TENRDR
V
YH
A
AM
MD
P
HTA
A
V
L
G
IDE
I
Y
AL
V
D
D
LI
A
AH
GD
WLP
GW
fig|562.376.peg.1792
Escherichia coli WV_060327 (1-448/451)
M
MSA
P
K
IT
F
IG
A
GST
I
FV
KN
ILG
D
V
FHREA
L
K
TAH
I
A
L
M
D
I
D
PT
R
LEESH
I
--V
V
R
K
L
MD
S
AG
ASG
K
ITC
H
T
Q
Q
K
EAL
Q
DADFV
VVAF
QI
G
G
Y
E
P
C
TVT
D
F
E
VCK
RHG
-
L
E
Q
TIAD
T
L
GPGGI
MR
A
LRTIP
H
L
W
QI
C
E
DM
T
E
V
CP
D
A
T
MLNY
V
NP
M
AM
N
T
W
A
M
Y
A
RY
P
HI
K
Q
V
GLCH
S
VQ
G
TVEE
L
A
RD
L
N
I
-
D
PAT
LR
Y
R
CA
G
I
NHM
AFYLE
L
E
R
KTAD
G
S
YV
N
L
Y
PELL
--
-
-
--------------
A
AYEA
GQA
PK
PN
I
HG-
-----------
--
NT
RC
Q
N
IV
R
Y
E
M
F
K
K
L
G
YFVT
E
SS
EH
F-
A
EYTPW
F
I
K
PG
RED
L
I
E
R
YK
V
P
LDEYPKRCVE
Q
L
ANWH
KELE
EYKN
A
SRI
D
I
KPSREY
A
S
TI
M
NAI
W
T
--------
G
E
P
S
VI
Y
G
N
----------------
V
R
N
D
G
L
IDN
L
P
QGCC
VE
V
A
C
L
V
D
A
NG
IQ
P
T
-
----
K
A
GT
L
PSHLA
A
LM
Q
T
NIN
V
Q
T
L
LT
E
A
I
L
TENRDR
V
YH
A
AM
MD
P
HTA
A
V
L
G
IDE
I
Y
AL
V
D
D
LI
A
AH
GD
WLP
GW
fig|749545.3.peg.2423
Escherichia coli MS 182-1 (6-448/451)
K
IT
F
IG
A
GST
I
FV
KN
ILG
D
V
FHREA
L
K
TAH
I
A
L
M
D
I
D
PT
R
LEESH
I
--V
V
R
K
L
MD
S
AG
ASG
K
ITC
H
T
Q
Q
K
EAL
Q
DADFV
VVAF
QI
G
G
Y
E
P
C
TVT
D
F
E
VCK
RHG
-
L
E
Q
TIAD
T
L
GPGGI
MR
A
LRTIP
H
L
W
QI
C
E
DM
T
E
V
CP
D
A
T
MLNY
V
NP
M
AM
N
T
W
A
M
Y
A
RY
P
HI
K
Q
V
GLCH
S
VQ
G
TAEE
L
A
RD
L
N
I
-
D
PAT
LR
Y
R
CA
G
I
NHM
AFYLE
L
E
R
KTAD
G
S
YV
N
L
Y
PELL
--
-
-
--------------
A
AYEA
GQA
PK
PN
I
HG-
-----------
--
NT
RC
Q
N
IV
R
Y
E
M
F
K
K
L
G
YFVT
E
SS
EH
F-
A
EYTPW
F
I
K
PG
RED
L
I
E
R
YK
V
P
LDEYPKRCVE
Q
L
ANWH
KELE
EYKN
A
SRI
D
I
KPSREY
A
S
TI
M
NAI
W
T
--------
G
E
P
S
VI
Y
G
N
----------------
V
R
N
D
G
L
IDN
L
P
QGCC
VE
V
A
C
L
V
D
A
NG
IQ
P
T
-
----
K
V
GT
L
PSHLA
A
LM
Q
T
NIN
V
Q
T
L
LT
E
A
I
L
TENRDR
V
NH
A
AM
MD
P
HTA
A
V
L
G
IDE
I
Y
AL
V
D
D
LI
A
AH
GD
WLP
GW
fig|749532.3.peg.4576
Escherichia coli MS 78-1 (6-448/451)
K
IT
F
IG
A
GST
I
FV
KN
ILG
D
V
FHREA
L
K
TAH
I
A
L
M
D
I
D
PT
R
LEESH
I
--V
V
R
K
L
MD
S
AG
ASG
K
ITC
H
T
Q
Q
K
EAL
Q
DADFV
VVAF
QI
G
G
Y
E
P
C
TVT
D
F
E
VCK
RHG
-
L
E
Q
TIAD
T
L
GPGGI
MR
A
LRTIP
H
L
W
QI
C
E
DM
T
E
V
CP
D
A
T
MLNY
V
NP
M
AM
N
T
W
A
M
Y
A
RY
P
HI
K
Q
V
GLCH
S
VQ
G
TAEE
L
A
RD
L
N
I
-
D
PAT
LR
Y
R
CA
G
I
NHM
AFYLE
L
E
R
KTAD
G
S
YV
N
L
Y
PELL
--
-
-
--------------
A
AYEA
GQA
PK
PN
I
HG-
-----------
--
NT
RC
Q
N
IV
R
Y
E
M
F
K
K
L
G
YFVT
E
SS
EH
F-
A
EYTPW
F
I
K
PG
RED
L
I
E
R
YK
V
P
LDEYPKRCVE
Q
L
ANWH
KELE
EYKN
A
SRI
D
I
KPS
Q
EY
A
S
TI
M
NAI
W
T
--------
G
E
P
S
VI
Y
G
N
----------------
V
R
N
D
G
L
IDN
L
P
QGCC
VE
V
A
C
L
V
D
A
NG
IQ
P
T
-
----
K
V
GT
L
PSHLA
A
LM
Q
T
NIN
V
Q
T
L
LT
E
A
I
L
TENRDR
V
NH
A
AM
MD
P
HTA
A
V
L
G
IDE
I
Y
AL
V
D
D
LI
A
AH
GD
WLP
GW
fig|358709.5.peg.1870
Escherichia coli 101-1 (6-448/451)
K
IT
F
IG
A
GST
I
FV
KN
ILG
D
V
FHREA
L
K
TAH
I
A
L
M
D
I
D
PT
R
LEESH
I
--V
V
R
K
L
MD
S
AG
ASG
K
ITC
H
T
Q
Q
K
EAL
Q
DADFV
VVAF
QI
G
G
Y
E
P
C
TVT
D
F
E
VCK
RHG
-
L
E
Q
TIAD
T
L
GPGGI
MR
A
LRTIP
H
L
W
QI
C
E
DM
T
E
V
CP
D
A
T
MLNY
V
NP
M
AM
N
T
W
A
M
Y
A
RY
P
HI
K
Q
V
GLCH
S
VQ
G
TAEE
L
A
RD
L
N
I
-
D
PAT
LR
Y
R
CA
G
I
NHM
AFYLE
L
E
R
KTAD
G
S
YV
N
L
Y
PELL
--
-
-
--------------
A
AHDA
GQA
PK
PN
I
HG-
-----------
--
NT
RC
Q
N
IV
R
Y
E
M
F
K
K
L
G
YFVT
E
SS
EH
F-
A
EYTPW
F
I
K
PG
RED
L
I
E
R
YK
V
P
LDEYPKRCVE
Q
L
ANWH
KELE
EYKN
A
SRI
D
I
KPSREY
A
S
TI
M
NAI
W
T
--------
G
E
P
S
VI
Y
G
N
----------------
V
R
N
D
G
L
IDN
L
P
QGCC
VE
V
A
C
L
V
D
A
NG
IQ
P
T
-
----
K
V
GT
L
PSHLA
A
LM
Q
T
NIN
V
Q
T
L
LT
E
A
I
L
TENRDR
V
YH
A
AM
MD
P
HTA
A
V
L
G
IDE
I
Y
AL
V
D
D
LI
A
AH
GD
WLP
GW
fig|413997.3.peg.4209
Escherichia coli B str. REL606 (6-448/451)
K
IT
F
IG
A
GST
I
FV
KN
ILG
D
V
FHREA
L
K
TAH
I
A
L
M
D
I
D
PT
R
LEESH
I
--V
V
R
K
L
MD
S
AG
ASG
K
ITC
H
T
Q
Q
K
EAL
Q
DADFV
VVAF
QI
G
G
Y
E
P
C
TVT
D
F
E
VCK
RHG
-
L
E
Q
TIAD
T
L
GPGGI
MR
A
LRTIP
H
L
W
QI
C
E
DM
T
E
V
CP
D
A
T
MLNY
V
NP
M
AM
N
T
W
A
M
Y
A
RY
P
HI
K
Q
V
GLCH
S
VQ
G
TAEE
L
A
RD
L
N
I
-
D
PAT
LR
Y
R
CA
G
I
NHM
AFYLE
L
E
R
KTAD
G
S
YV
N
L
Y
PELL
--
-
-
--------------
A
AHDA
GQA
PK
PN
I
HG-
-----------
--
NT
RC
Q
N
IV
R
Y
E
M
F
K
K
L
G
YFVT
E
SS
EH
F-
A
EYTPW
F
I
K
PG
RED
L
I
E
R
YK
V
P
LDEYPKRCVE
Q
L
ANWH
KELE
EYKN
A
SRI
D
I
KPSREY
A
S
TI
M
NAI
W
T
--------
G
E
P
S
VI
Y
G
N
----------------
V
R
N
D
G
L
IDN
L
P
QGCC
VE
V
A
C
L
V
D
A
NG
IQ
P
T
-
----
K
V
GT
L
PSHLA
A
LM
Q
T
NIN
V
Q
T
L
LT
E
A
I
L
TENRDR
V
YH
A
AM
MD
P
HTA
A
V
L
G
IDE
I
Y
AL
V
D
D
LI
A
AH
GD
WLP
GW
fig|511693.5.peg.4230
Escherichia coli BL21 (6-448/451)
K
IT
F
IG
A
GST
I
FV
KN
ILG
D
V
FHREA
L
K
TAH
I
A
L
M
D
I
D
PT
R
LEESH
I
--V
V
R
K
L
MD
S
AG
ASG
K
ITC
H
T
Q
Q
K
EAL
Q
DADFV
VVAF
QI
G
G
Y
E
P
C
TVT
D
F
E
VCK
RHG
-
L
E
Q
TIAD
T
L
GPGGI
MR
A
LRTIP
H
L
W
QI
C
E
DM
T
E
V
CP
D
A
T
MLNY
V
NP
M
AM
N
T
W
A
M
Y
A
RY
P
HI
K
Q
V
GLCH
S
VQ
G
TAEE
L
A
RD
L
N
I
-
D
PAT
LR
Y
R
CA
G
I
NHM
AFYLE
L
E
R
KTAD
G
S
YV
N
L
Y
PELL
--
-
-
--------------
A
AHDA
GQA
PK
PN
I
HG-
-----------
--
NT
RC
Q
N
IV
R
Y
E
M
F
K
K
L
G
YFVT
E
SS
EH
F-
A
EYTPW
F
I
K
PG
RED
L
I
E
R
YK
V
P
LDEYPKRCVE
Q
L
ANWH
KELE
EYKN
A
SRI
D
I
KPSREY
A
S
TI
M
NAI
W
T
--------
G
E
P
S
VI
Y
G
N
----------------
V
R
N
D
G
L
IDN
L
P
QGCC
VE
V
A
C
L
V
D
A
NG
IQ
P
T
-
----
K
V
GT
L
PSHLA
A
LM
Q
T
NIN
V
Q
T
L
LT
E
A
I
L
TENRDR
V
YH
A
AM
MD
P
HTA
A
V
L
G
IDE
I
Y
AL
V
D
D
LI
A
AH
GD
WLP
GW
fig|469008.4.peg.4060
Escherichia coli BL21(DE3) (6-448/451)
K
IT
F
IG
A
GST
I
FV
KN
ILG
D
V
FHREA
L
K
TAH
I
A
L
M
D
I
D
PT
R
LEESH
I
--V
V
R
K
L
MD
S
AG
ASG
K
ITC
H
T
Q
Q
K
EAL
Q
DADFV
VVAF
QI
G
G
Y
E
P
C
TVT
D
F
E
VCK
RHG
-
L
E
Q
TIAD
T
L
GPGGI
MR
A
LRTIP
H
L
W
QI
C
E
DM
T
E
V
CP
D
A
T
MLNY
V
NP
M
AM
N
T
W
A
M
Y
A
RY
P
HI
K
Q
V
GLCH
S
VQ
G
TAEE
L
A
RD
L
N
I
-
D
PAT
LR
Y
R
CA
G
I
NHM
AFYLE
L
E
R
KTAD
G
S
YV
N
L
Y
PELL
--
-
-
--------------
A
AHDA
GQA
PK
PN
I
HG-
-----------
--
NT
RC
Q
N
IV
R
Y
E
M
F
K
K
L
G
YFVT
E
SS
EH
F-
A
EYTPW
F
I
K
PG
RED
L
I
E
R
YK
V
P
LDEYPKRCVE
Q
L
ANWH
KELE
EYKN
A
SRI
D
I
KPSREY
A
S
TI
M
NAI
W
T
--------
G
E
P
S
VI
Y
G
N
----------------
V
R
N
D
G
L
IDN
L
P
QGCC
VE
V
A
C
L
V
D
A
NG
IQ
P
T
-
----
K
V
GT
L
PSHLA
A
LM
Q
T
NIN
V
Q
T
L
LT
E
A
I
L
TENRDR
V
YH
A
AM
MD
P
HTA
A
V
L
G
IDE
I
Y
AL
V
D
D
LI
A
AH
GD
WLP
GW
fig|749547.3.peg.2663
Escherichia coli MS 187-1 (6-448/451)
K
IT
F
IG
A
GST
I
FV
KN
ILG
D
V
FHREA
L
K
TAH
I
A
L
M
D
I
D
PT
R
LEESH
I
--V
V
R
K
L
MD
S
AG
ASG
K
ITC
H
T
Q
Q
K
EAL
Q
DADFV
VVAF
QI
G
G
Y
E
P
C
TVT
D
F
E
VCK
RHG
-
L
E
Q
TIAD
T
L
GPGGI
MR
A
LRTIP
H
L
W
QI
C
E
DM
T
E
V
CP
D
A
T
MLNY
V
NP
M
AM
N
T
W
A
M
Y
A
RY
P
HI
K
Q
V
GLCH
S
VQ
G
TAEE
L
A
RD
L
N
I
-
D
PAT
LR
Y
R
CA
G
I
NHM
AFYLE
L
E
R
KTAD
G
S
YV
N
L
Y
PELL
--
-
-
--------------
A
AHDA
GQA
PK
PN
I
HG-
-----------
--
NT
RC
Q
N
IV
R
Y
E
M
F
K
K
L
G
YFVT
E
SS
EH
F-
A
EYTPW
F
I
K
PG
RED
L
I
E
R
YK
V
P
LDEYPKRCVE
Q
L
ANWH
KELE
EYKN
A
SRI
D
I
KPSREY
A
S
TI
M
NAI
W
T
--------
G
E
P
S
VI
Y
G
N
----------------
V
R
N
D
G
L
IDN
L
P
QGCC
VE
V
A
C
L
V
D
A
NG
IQ
P
T
-
----
K
V
GT
L
PSHLA
A
LM
Q
T
NIN
V
Q
T
L
LT
E
A
I
L
TENRDR
V
YH
A
AM
MD
P
HTA
A
V
L
G
IDE
I
Y
AL
V
D
D
LI
A
AH
GD
WLP
GW
fig|656393.3.peg.235
Escherichia coli H299 (1-448/451)
M
MSA
P
K
IT
F
IG
A
GST
I
FV
KN
ILG
D
V
FHREA
L
K
TAH
I
A
L
M
D
I
D
PT
R
LEESH
I
--V
V
R
K
L
MD
S
AG
ASG
K
ITC
H
T
Q
Q
K
EAL
Q
DADFV
VVAF
QI
G
G
Y
E
P
C
TVT
D
F
E
VCK
RHG
-
L
E
Q
TIAD
T
L
GPGGI
MR
A
LRTIP
H
L
W
QI
C
E
DM
T
E
V
CP
D
A
T
MLNY
V
NP
M
AM
N
T
W
A
M
Y
A
RY
P
HI
K
Q
V
GLCH
S
VQ
G
TAEE
L
A
RD
L
N
I
-
D
PAT
LR
Y
R
CA
G
I
NHM
AFYLE
L
E
R
KTAD
G
S
YV
N
L
Y
PELL
--
-
-
--------------
A
VYEA
GQA
PK
PN
I
HG-
-----------
--
NT
RC
Q
N
IV
R
Y
E
M
F
K
K
L
G
YFVT
E
SS
EH
F-
A
EYTPW
F
I
K
PG
RED
L
I
E
R
YK
V
P
LDEYPKRCVE
Q
L
ANWH
KELE
EYKN
A
SRI
D
I
KPSREY
A
S
TI
M
NAI
W
T
--------
G
E
P
S
VI
Y
G
N
----------------
V
R
N
D
G
L
IDN
L
P
QGCC
VE
V
A
C
L
V
D
A
NG
IQ
P
T
-
----
K
V
GT
L
PSHLA
A
LM
Q
T
NIN
V
Q
T
L
LT
E
A
I
L
TENRDR
V
YH
A
AM
MD
P
HTA
A
V
L
G
IDE
I
Y
AL
V
D
D
LI
A
AH
GD
WLP
GW
fig|155864.1.peg.5060
Escherichia coli O157:H7 EDL933 (1-448/451)
M
MSA
P
K
IT
F
IG
A
GST
I
FV
KN
ILG
D
V
FHREA
L
K
TAH
I
A
L
M
D
I
D
PT
R
LEESH
I
--V
V
R
K
L
MD
S
AG
ASG
K
ITC
H
T
Q
Q
K
EAL
Q
DADFV
VVAF
QI
G
G
Y
A
P
C
TVT
D
F
E
VCK
RHG
-
L
E
Q
TIAD
T
L
GPGGI
MR
A
LRTIP
H
L
W
QI
C
E
DM
T
E
V
CP
D
A
T
M
X
NY
V
NP
M
AM
N
T
W
A
M
Y
A
RY
P
HI
K
Q
V
GLCH
S
VQ
G
TAEE
L
A
RD
L
N
I
-
D
PAT
LR
Y
R
CA
G
I
NHM
AFYLE
L
E
R
KTAD
G
S
YV
N
L
Y
PELL
--
-
-
--------------
A
AYDA
GQA
PK
PN
I
HG-
-----------
--
NT
RC
Q
N
IV
R
Y
E
M
F
K
K
L
G
YFVT
E
SS
EH
F-
A
EYTPW
F
I
K
PG
RED
L
I
E
R
YK
V
P
LDEYPKRCVE
Q
L
ANWH
KELE
EYKN
A
SRI
D
I
KPSREY
A
S
TI
M
NAI
W
T
--------
G
E
P
S
VI
Y
G
N
----------------
V
R
N
D
G
L
IDN
L
P
QGCC
VE
V
A
C
L
V
D
A
NG
IQ
P
T
-
----
K
V
GT
L
PSHLA
A
LM
Q
T
NIN
V
Q
T
L
LT
E
A
I
L
TENRDR
V
YH
A
AM
MD
P
HTA
A
V
L
G
IDE
I
Y
AL
V
D
D
LI
A
AH
GD
WLP
GW
fig|155864.8.peg.5043
Escherichia coli O157:H7 EDL933 (1-448/451)
M
MSA
P
K
IT
F
IG
A
GST
I
FV
KN
ILG
D
V
FHREA
L
K
TAH
I
A
L
M
D
I
D
PT
R
LEESH
I
--V
V
R
K
L
MD
S
AG
ASG
K
ITC
H
T
Q
Q
K
EAL
Q
DADFV
VVAF
QI
G
G
Y
A
P
C
TVT
D
F
E
VCK
RHG
-
L
E
Q
TIAD
T
L
GPGGI
MR
A
LRTIP
H
L
W
QI
C
E
DM
T
E
V
CP
D
A
T
M
X
NY
V
NP
M
AM
N
T
W
A
M
Y
A
RY
P
HI
K
Q
V
GLCH
S
VQ
G
TAEE
L
A
RD
L
N
I
-
D
PAT
LR
Y
R
CA
G
I
NHM
AFYLE
L
E
R
KTAD
G
S
YV
N
L
Y
PELL
--
-
-
--------------
A
AYDA
GQA
PK
PN
I
HG-
-----------
--
NT
RC
Q
N
IV
R
Y
E
M
F
K
K
L
G
YFVT
E
SS
EH
F-
A
EYTPW
F
I
K
PG
RED
L
I
E
R
YK
V
P
LDEYPKRCVE
Q
L
ANWH
KELE
EYKN
A
SRI
D
I
KPSREY
A
S
TI
M
NAI
W
T
--------
G
E
P
S
VI
Y
G
N
----------------
V
R
N
D
G
L
IDN
L
P
QGCC
VE
V
A
C
L
V
D
A
NG
IQ
P
T
-
----
K
V
GT
L
PSHLA
A
LM
Q
T
NIN
V
Q
T
L
LT
E
A
I
L
TENRDR
V
YH
A
AM
MD
P
HTA
A
V
L
G
IDE
I
Y
AL
V
D
D
LI
A
AH
GD
WLP
GW
fig|362663.8.peg.4396
Escherichia coli 536 (1-448/451)
M
MSA
P
K
IT
F
IG
A
GST
I
FV
KN
ILG
D
V
FHREA
L
K
TAH
I
A
L
M
D
I
D
PT
R
LEESH
I
--V
V
R
K
L
MD
S
AG
ASG
K
ITC
H
T
Q
Q
K
EAL
Q
DADFV
VVAF
QI
G
G
Y
E
P
C
TVT
D
F
E
VCK
RHG
-
L
E
Q
TIAD
T
L
GPGGI
MR
A
LRTIP
H
L
W
QI
C
E
DM
T
E
V
CP
D
A
T
MLNY
V
NP
M
AM
N
T
W
A
M
Y
A
RY
P
HI
K
Q
V
GLCH
S
VQ
G
TAEE
L
A
RD
L
N
I
-
D
PAT
LR
Y
R
CA
G
I
NHM
AFYLE
L
E
R
KTAD
G
S
YV
N
L
Y
PELL
--
-
-
--------------
A
AYEA
GQA
PK
PN
I
HG-
-----------
--
NT
RC
Q
N
IV
R
Y
E
M
F
K
K
L
G
YFVT
E
SS
EH
F-
A
EYTPW
F
I
K
PG
RED
L
I
E
R
YK
V
P
LDEYPKRCVE
Q
L
ANWH
KELE
EYKN
A
SRI
D
I
KPSREY
A
S
TI
M
NAI
W
T
--------
G
E
P
S
VI
Y
G
N
----------------
V
R
N
D
G
L
IDN
L
P
QGCC
VE
V
A
C
L
V
D
A
NG
IQ
P
T
-
----
K
A
GT
L
PSHLA
A
LM
Q
T
NIN
V
Q
T
L
LT
E
A
I
L
TENRDR
V
YH
A
AM
MD
P
HTA
A
V
L
G
IDE
I
Y
AL
V
D
D
LI
A
AH
GD
WLP
GW
fig|362663.9.peg.4412
Escherichia coli 536 (1-448/451)
M
MSA
P
K
IT
F
IG
A
GST
I
FV
KN
ILG
D
V
FHREA
L
K
TAH
I
A
L
M
D
I
D
PT
R
LEESH
I
--V
V
R
K
L
MD
S
AG
ASG
K
ITC
H
T
Q
Q
K
EAL
Q
DADFV
VVAF
QI
G
G
Y
E
P
C
TVT
D
F
E
VCK
RHG
-
L
E
Q
TIAD
T
L
GPGGI
MR
A
LRTIP
H
L
W
QI
C
E
DM
T
E
V
CP
D
A
T
MLNY
V
NP
M
AM
N
T
W
A
M
Y
A
RY
P
HI
K
Q
V
GLCH
S
VQ
G
TAEE
L
A
RD
L
N
I
-
D
PAT
LR
Y
R
CA
G
I
NHM
AFYLE
L
E
R
KTAD
G
S
YV
N
L
Y
PELL
--
-
-
--------------
A
AYEA
GQA
PK
PN
I
HG-
-----------
--
NT
RC
Q
N
IV
R
Y
E
M
F
K
K
L
G
YFVT
E
SS
EH
F-
A
EYTPW
F
I
K
PG
RED
L
I
E
R
YK
V
P
LDEYPKRCVE
Q
L
ANWH
KELE
EYKN
A
SRI
D
I
KPSREY
A
S
TI
M
NAI
W
T
--------
G
E
P
S
VI
Y
G
N
----------------
V
R
N
D
G
L
IDN
L
P
QGCC
VE
V
A
C
L
V
D
A
NG
IQ
P
T
-
----
K
A
GT
L
PSHLA
A
LM
Q
T
NIN
V
Q
T
L
LT
E
A
I
L
TENRDR
V
YH
A
AM
MD
P
HTA
A
V
L
G
IDE
I
Y
AL
V
D
D
LI
A
AH
GD
WLP
GW
fig|405955.13.peg.4622
Escherichia coli APEC O1 (1-448/451)
M
MSA
P
K
IT
F
IG
A
GST
I
FV
KN
ILG
D
V
FHREA
L
K
TAH
I
A
L
M
D
I
D
PT
R
LEESH
I
--V
V
R
K
L
MD
S
AG
ASG
K
ITC
H
T
Q
Q
K
EAL
Q
DADFV
VVAF
QI
G
G
Y
E
P
C
TVT
D
F
E
VCK
RHG
-
L
E
Q
TIAD
T
L
GPGGI
MR
A
LRTIP
H
L
W
QI
C
E
DM
T
E
V
CP
D
A
T
MLNY
V
NP
M
AM
N
T
W
A
M
Y
A
RY
P
HI
K
Q
V
GLCH
S
VQ
G
TAEE
L
A
RD
L
N
I
-
D
PAT
LR
Y
R
CA
G
I
NHM
AFYLE
L
E
R
KTAD
G
S
YV
N
L
Y
PELL
--
-
-
--------------
A
AYEA
GQA
PK
PN
I
HG-
-----------
--
NT
RC
Q
N
IV
R
Y
E
M
F
K
K
L
G
YFVT
E
SS
EH
F-
A
EYTPW
F
I
K
PG
RED
L
I
E
R
YK
V
P
LDEYPKRCVE
Q
L
ANWH
KELE
EYKN
A
SRI
D
I
KPSREY
A
S
TI
M
NAI
W
T
--------
G
E
P
S
VI
Y
G
N
----------------
V
R
N
D
G
L
IDN
L
P
QGCC
VE
V
A
C
L
V
D
A
NG
IQ
P
T
-
----
K
A
GT
L
PSHLA
A
LM
Q
T
NIN
V
Q
T
L
LT
E
A
I
L
TENRDR
V
YH
A
AM
MD
P
HTA
A
V
L
G
IDE
I
Y
AL
V
D
D
LI
A
AH
GD
WLP
GW
fig|405955.9.peg.3908
Escherichia coli APEC O1 (1-448/451)
M
MSA
P
K
IT
F
IG
A
GST
I
FV
KN
ILG
D
V
FHREA
L
K
TAH
I
A
L
M
D
I
D
PT
R
LEESH
I
--V
V
R
K
L
MD
S
AG
ASG
K
ITC
H
T
Q
Q
K
EAL
Q
DADFV
VVAF
QI
G
G
Y
E
P
C
TVT
D
F
E
VCK
RHG
-
L
E
Q
TIAD
T
L
GPGGI
MR
A
LRTIP
H
L
W
QI
C
E
DM
T
E
V
CP
D
A
T
MLNY
V
NP
M
AM
N
T
W
A
M
Y
A
RY
P
HI
K
Q
V
GLCH
S
VQ
G
TAEE
L
A
RD
L
N
I
-
D
PAT
LR
Y
R
CA
G
I
NHM
AFYLE
L
E
R
KTAD
G
S
YV
N
L
Y
PELL
--
-
-
--------------
A
AYEA
GQA
PK
PN
I
HG-
-----------
--
NT
RC
Q
N
IV
R
Y
E
M
F
K
K
L
G
YFVT
E
SS
EH
F-
A
EYTPW
F
I
K
PG
RED
L
I
E
R
YK
V
P
LDEYPKRCVE
Q
L
ANWH
KELE
EYKN
A
SRI
D
I
KPSREY
A
S
TI
M
NAI
W
T
--------
G
E
P
S
VI
Y
G
N
----------------
V
R
N
D
G
L
IDN
L
P
QGCC
VE
V
A
C
L
V
D
A
NG
IQ
P
T
-
----
K
A
GT
L
PSHLA
A
LM
Q
T
NIN
V
Q
T
L
LT
E
A
I
L
TENRDR
V
YH
A
AM
MD
P
HTA
A
V
L
G
IDE
I
Y
AL
V
D
D
LI
A
AH
GD
WLP
GW
fig|585397.7.peg.4840
Escherichia coli ED1a (1-448/451)
M
MSA
P
K
IT
F
IG
A
GST
I
FV
KN
ILG
D
V
FHREA
L
K
TAH
I
A
L
M
D
I
D
PT
R
LEESH
I
--V
V
R
K
L
MD
S
AG
ASG
K
ITC
H
T
Q
Q
K
EAL
Q
DADFV
VVAF
QI
G
G
Y
E
P
C
TVT
D
F
E
VCK
RHG
-
L
E
Q
TIAD
T
L
GPGGI
MR
A
LRTIP
H
L
W
QI
C
E
DM
T
E
V
CP
D
A
T
MLNY
V
NP
M
AM
N
T
W
A
M
Y
A
RY
P
HI
K
Q
V
GLCH
S
VQ
G
TAEE
L
A
RD
L
N
I
-
D
PAT
LR
Y
R
CA
G
I
NHM
AFYLE
L
E
R
KTAD
G
S
YV
N
L
Y
PELL
--
-
-
--------------
A
AYEA
GQA
PK
PN
I
HG-
-----------
--
NT
RC
Q
N
IV
R
Y
E
M
F
K
K
L
G
YFVT
E
SS
EH
F-
A
EYTPW
F
I
K
PG
RED
L
I
E
R
YK
V
P
LDEYPKRCVE
Q
L
ANWH
KELE
EYKN
A
SRI
D
I
KPSREY
A
S
TI
M
NAI
W
T
--------
G
E
P
S
VI
Y
G
N
----------------
V
R
N
D
G
L
IDN
L
P
QGCC
VE
V
A
C
L
V
D
A
NG
IQ
P
T
-
----
K
A
GT
L
PSHLA
A
LM
Q
T
NIN
V
Q
T
L
LT
E
A
I
L
TENRDR
V
YH
A
AM
MD
P
HTA
A
V
L
G
IDE
I
Y
AL
V
D
D
LI
A
AH
GD
WLP
GW
fig|585397.9.peg.4840
Escherichia coli ED1a (1-448/451)
M
MSA
P
K
IT
F
IG
A
GST
I
FV
KN
ILG
D
V
FHREA
L
K
TAH
I
A
L
M
D
I
D
PT
R
LEESH
I
--V
V
R
K
L
MD
S
AG
ASG
K
ITC
H
T
Q
Q
K
EAL
Q
DADFV
VVAF
QI
G
G
Y
E
P
C
TVT
D
F
E
VCK
RHG
-
L
E
Q
TIAD
T
L
GPGGI
MR
A
LRTIP
H
L
W
QI
C
E
DM
T
E
V
CP
D
A
T
MLNY
V
NP
M
AM
N
T
W
A
M
Y
A
RY
P
HI
K
Q
V
GLCH
S
VQ
G
TAEE
L
A
RD
L
N
I
-
D
PAT
LR
Y
R
CA
G
I
NHM
AFYLE
L
E
R
KTAD
G
S
YV
N
L
Y
PELL
--
-
-
--------------
A
AYEA
GQA
PK
PN
I
HG-
-----------
--
NT
RC
Q
N
IV
R
Y
E
M
F
K
K
L
G
YFVT
E
SS
EH
F-
A
EYTPW
F
I
K
PG
RED
L
I
E
R
YK
V
P
LDEYPKRCVE
Q
L
ANWH
KELE
EYKN
A
SRI
D
I
KPSREY
A
S
TI
M
NAI
W
T
--------
G
E
P
S
VI
Y
G
N
----------------
V
R
N
D
G
L
IDN
L
P
QGCC
VE
V
A
C
L
V
D
A
NG
IQ
P
T
-
----
K
A
GT
L
PSHLA
A
LM
Q
T
NIN
V
Q
T
L
LT
E
A
I
L
TENRDR
V
YH
A
AM
MD
P
HTA
A
V
L
G
IDE
I
Y
AL
V
D
D
LI
A
AH
GD
WLP
GW
fig|340197.3.peg.3469
Escherichia coli F11 (1-448/451)
M
MSA
P
K
IT
F
IG
A
GST
I
FV
KN
ILG
D
V
FHREA
L
K
TAH
I
A
L
M
D
I
D
PT
R
LEESH
I
--V
V
R
K
L
MD
S
AG
ASG
K
ITC
H
T
Q
Q
K
EAL
Q
DADFV
VVAF
QI
G
G
Y
E
P
C
TVT
D
F
E
VCK
RHG
-
L
E
Q
TIAD
T
L
GPGGI
MR
A
LRTIP
H
L
W
QI
C
E
DM
T
E
V
CP
D
A
T
MLNY
V
NP
M
AM
N
T
W
A
M
Y
A
RY
P
HI
K
Q
V
GLCH
S
VQ
G
TAEE
L
A
RD
L
N
I
-
D
PAT
LR
Y
R
CA
G
I
NHM
AFYLE
L
E
R
KTAD
G
S
YV
N
L
Y
PELL
--
-
-
--------------
A
AYEA
GQA
PK
PN
I
HG-
-----------
--
NT
RC
Q
N
IV
R
Y
E
M
F
K
K
L
G
YFVT
E
SS
EH
F-
A
EYTPW
F
I
K
PG
RED
L
I
E
R
YK
V
P
LDEYPKRCVE
Q
L
ANWH
KELE
EYKN
A
SRI
D
I
KPSREY
A
S
TI
M
NAI
W
T
--------
G
E
P
S
VI
Y
G
N
----------------
V
R
N
D
G
L
IDN
L
P
QGCC
VE
V
A
C
L
V
D
A
NG
IQ
P
T
-
----
K
A
GT
L
PSHLA
A
LM
Q
T
NIN
V
Q
T
L
LT
E
A
I
L
TENRDR
V
YH
A
AM
MD
P
HTA
A
V
L
G
IDE
I
Y
AL
V
D
D
LI
A
AH
GD
WLP
GW
fig|340197.5.peg.3636
Escherichia coli F11 (1-448/451)
M
MSA
P
K
IT
F
IG
A
GST
I
FV
KN
ILG
D
V
FHREA
L
K
TAH
I
A
L
M
D
I
D
PT
R
LEESH
I
--V
V
R
K
L
MD
S
AG
ASG
K
ITC
H
T
Q
Q
K
EAL
Q
DADFV
VVAF
QI
G
G
Y
E
P
C
TVT
D
F
E
VCK
RHG
-
L
E
Q
TIAD
T
L
GPGGI
MR
A
LRTIP
H
L
W
QI
C
E
DM
T
E
V
CP
D
A
T
MLNY
V
NP
M
AM
N
T
W
A
M
Y
A
RY
P
HI
K
Q
V
GLCH
S
VQ
G
TAEE
L
A
RD
L
N
I
-
D
PAT
LR
Y
R
CA
G
I
NHM
AFYLE
L
E
R
KTAD
G
S
YV
N
L
Y
PELL
--
-
-
--------------
A
AYEA
GQA
PK
PN
I
HG-
-----------
--
NT
RC
Q
N
IV
R
Y
E
M
F
K
K
L
G
YFVT
E
SS
EH
F-
A
EYTPW
F
I
K
PG
RED
L
I
E
R
YK
V
P
LDEYPKRCVE
Q
L
ANWH
KELE
EYKN
A
SRI
D
I
KPSREY
A
S
TI
M
NAI
W
T
--------
G
E
P
S
VI
Y
G
N
----------------
V
R
N
D
G
L
IDN
L
P
QGCC
VE
V
A
C
L
V
D
A
NG
IQ
P
T
-
----
K
A
GT
L
PSHLA
A
LM
Q
T
NIN
V
Q
T
L
LT
E
A
I
L
TENRDR
V
YH
A
AM
MD
P
HTA
A
V
L
G
IDE
I
Y
AL
V
D
D
LI
A
AH
GD
WLP
GW
fig|585057.4.peg.4683
Escherichia coli IAI39 (1-448/451)
M
MSA
P
K
IT
F
IG
A
GST
I
FV
KN
ILG
D
V
FHREA
L
K
TAH
I
A
L
M
D
I
D
PT
R
LEESH
I
--V
V
R
K
L
MD
S
AG
ASG
K
ITC
H
T
Q
Q
K
EAL
Q
DADFV
VVAF
QI
G
G
Y
E
P
C
TVT
D
F
E
VCK
RHG
-
L
E
Q
TIAD
T
L
GPGGI
MR
A
LRTIP
H
L
W
QI
C
E
DM
T
E
V
CP
D
A
T
MLNY
V
NP
M
AM
N
T
W
A
M
Y
A
RY
P
HI
K
Q
V
GLCH
S
VQ
G
TAEE
L
A
RD
L
N
I
-
D
PAT
LR
Y
R
CA
G
I
NHM
AFYLE
L
E
R
KTAD
G
S
YV
N
L
Y
PELL
--
-
-
--------------
A
AYEA
GQA
PK
PN
I
HG-
-----------
--
NT
RC
Q
N
IV
R
Y
E
M
F
K
K
L
G
YFVT
E
SS
EH
F-
A
EYTPW
F
I
K
PG
RED
L
I
E
R
YK
V
P
LDEYPKRCVE
Q
L
ANWH
KELE
EYKN
A
SRI
D
I
KPSREY
A
S
TI
M
NAI
W
T
--------
G
E
P
S
VI
Y
G
N
----------------
V
R
N
D
G
L
IDN
L
P
QGCC
VE
V
A
C
L
V
D
A
NG
IQ
P
T
-
----
K
A
GT
L
PSHLA
A
LM
Q
T
NIN
V
Q
T
L
LT
E
A
I
L
TENRDR
V
YH
A
AM
MD
P
HTA
A
V
L
G
IDE
I
Y
AL
V
D
D
LI
A
AH
GD
WLP
GW
fig|585057.6.peg.4692
Escherichia coli IAI39 (1-448/451)
M
MSA
P
K
IT
F
IG
A
GST
I
FV
KN
ILG
D
V
FHREA
L
K
TAH
I
A
L
M
D
I
D
PT
R
LEESH
I
--V
V
R
K
L
MD
S
AG
ASG
K
ITC
H
T
Q
Q
K
EAL
Q
DADFV
VVAF
QI
G
G
Y
E
P
C
TVT
D
F
E
VCK
RHG
-
L
E
Q
TIAD
T
L
GPGGI
MR
A
LRTIP
H
L
W
QI
C
E
DM
T
E
V
CP
D
A
T
MLNY
V
NP
M
AM
N
T
W
A
M
Y
A
RY
P
HI
K
Q
V
GLCH
S
VQ
G
TAEE
L
A
RD
L
N
I
-
D
PAT
LR
Y
R
CA
G
I
NHM
AFYLE
L
E
R
KTAD
G
S
YV
N
L
Y
PELL
--
-
-
--------------
A
AYEA
GQA
PK
PN
I
HG-
-----------
--
NT
RC
Q
N
IV
R
Y
E
M
F
K
K
L
G
YFVT
E
SS
EH
F-
A
EYTPW
F
I
K
PG
RED
L
I
E
R
YK
V
P
LDEYPKRCVE
Q
L
ANWH
KELE
EYKN
A
SRI
D
I
KPSREY
A
S
TI
M
NAI
W
T
--------
G
E
P
S
VI
Y
G
N
----------------
V
R
N
D
G
L
IDN
L
P
QGCC
VE
V
A
C
L
V
D
A
NG
IQ
P
T
-
----
K
A
GT
L
PSHLA
A
LM
Q
T
NIN
V
Q
T
L
LT
E
A
I
L
TENRDR
V
YH
A
AM
MD
P
HTA
A
V
L
G
IDE
I
Y
AL
V
D
D
LI
A
AH
GD
WLP
GW
fig|714962.3.peg.4661
Escherichia coli IHE3034 (1-448/451)
M
MSA
P
K
IT
F
IG
A
GST
I
FV
KN
ILG
D
V
FHREA
L
K
TAH
I
A
L
M
D
I
D
PT
R
LEESH
I
--V
V
R
K
L
MD
S
AG
ASG
K
ITC
H
T
Q
Q
K
EAL
Q
DADFV
VVAF
QI
G
G
Y
E
P
C
TVT
D
F
E
VCK
RHG
-
L
E
Q
TIAD
T
L
GPGGI
MR
A
LRTIP
H
L
W
QI
C
E
DM
T
E
V
CP
D
A
T
MLNY
V
NP
M
AM
N
T
W
A
M
Y
A
RY
P
HI
K
Q
V
GLCH
S
VQ
G
TAEE
L
A
RD
L
N
I
-
D
PAT
LR
Y
R
CA
G
I
NHM
AFYLE
L
E
R
KTAD
G
S
YV
N
L
Y
PELL
--
-
-
--------------
A
AYEA
GQA
PK
PN
I
HG-
-----------
--
NT
RC
Q
N
IV
R
Y
E
M
F
K
K
L
G
YFVT
E
SS
EH
F-
A
EYTPW
F
I
K
PG
RED
L
I
E
R
YK
V
P
LDEYPKRCVE
Q
L
ANWH
KELE
EYKN
A
SRI
D
I
KPSREY
A
S
TI
M
NAI
W
T
--------
G
E
P
S
VI
Y
G
N
----------------
V
R
N
D
G
L
IDN
L
P
QGCC
VE
V
A
C
L
V
D
A
NG
IQ
P
T
-
----
K
A
GT
L
PSHLA
A
LM
Q
T
NIN
V
Q
T
L
LT
E
A
I
L
TENRDR
V
YH
A
AM
MD
P
HTA
A
V
L
G
IDE
I
Y
AL
V
D
D
LI
A
AH
GD
WLP
GW
fig|656417.3.peg.5205
Escherichia coli M605 (1-448/451)
M
MSA
P
K
IT
F
IG
A
GST
I
FV
KN
ILG
D
V
FHREA
L
K
TAH
I
A
L
M
D
I
D
PT
R
LEESH
I
--V
V
R
K
L
MD
S
AG
ASG
K
ITC
H
T
Q
Q
K
EAL
Q
DADFV
VVAF
QI
G
G
Y
E
P
C
TVT
D
F
E
VCK
RHG
-
L
E
Q
TIAD
T
L
GPGGI
MR
A
LRTIP
H
L
W
QI
C
E
DM
T
E
V
CP
D
A
T
MLNY
V
NP
M
AM
N
T
W
A
M
Y
A
RY
P
HI
K
Q
V
GLCH
S
VQ
G
TAEE
L
A
RD
L
N
I
-
D
PAT
LR
Y
R
CA
G
I
NHM
AFYLE
L
E
R
KTAD
G
S
YV
N
L
Y
PELL
--
-
-
--------------
A
AYEA
GQA
PK
PN
I
HG-
-----------
--
NT
RC
Q
N
IV
R
Y
E
M
F
K
K
L
G
YFVT
E
SS
EH
F-
A
EYTPW
F
I
K
PG
RED
L
I
E
R
YK
V
P
LDEYPKRCVE
Q
L
ANWH
KELE
EYKN
A
SRI
D
I
KPSREY
A
S
TI
M
NAI
W
T
--------
G
E
P
S
VI
Y
G
N
----------------
V
R
N
D
G
L
IDN
L
P
QGCC
VE
V
A
C
L
V
D
A
NG
IQ
P
T
-
----
K
A
GT
L
PSHLA
A
LM
Q
T
NIN
V
Q
T
L
LT
E
A
I
L
TENRDR
V
YH
A
AM
MD
P
HTA
A
V
L
G
IDE
I
Y
AL
V
D
D
LI
A
AH
GD
WLP
GW
fig|749550.3.peg.4439
Escherichia coli MS 200-1 (1-448/451)
M
MSA
P
K
IT
F
IG
A
GST
I
FV
KN
ILG
D
V
FHREA
L
K
TAH
I
A
L
M
D
I
D
PT
R
LEESH
I
--V
V
R
K
L
MD
S
AG
ASG
K
ITC
H
T
Q
Q
K
EAL
Q
DADFV
VVAF
QI
G
G
Y
E
P
C
TVT
D
F
E
VCK
RHG
-
L
E
Q
TIAD
T
L
GPGGI
MR
A
LRTIP
H
L
W
QI
C
E
DM
T
E
V
CP
D
A
T
MLNY
V
NP
M
AM
N
T
W
A
M
Y
A
RY
P
HI
K
Q
V
GLCH
S
VQ
G
TAEE
L
A
RD
L
N
I
-
D
PAT
LR
Y
R
CA
G
I
NHM
AFYLE
L
E
R
KTAD
G
S
YV
N
L
Y
PELL
--
-
-
--------------
A
AYEA
GQA
PK
PN
I
HG-
-----------
--
NT
RC
Q
N
IV
R
Y
E
M
F
K
K
L
G
YFVT
E
SS
EH
F-
A
EYTPW
F
I
K
PG
RED
L
I
E
R
YK
V
P
LDEYPKRCVE
Q
L
ANWH
KELE
EYKN
A
SRI
D
I
KPSREY
A
S
TI
M
NAI
W
T
--------
G
E
P
S
VI
Y
G
N
----------------
V
R
N
D
G
L
IDN
L
P
QGCC
VE
V
A
C
L
V
D
A
NG
IQ
P
T
-
----
K
A
GT
L
PSHLA
A
LM
Q
T
NIN
V
Q
T
L
LT
E
A
I
L
TENRDR
V
YH
A
AM
MD
P
HTA
A
V
L
G
IDE
I
Y
AL
V
D
D
LI
A
AH
GD
WLP
GW
fig|753642.3.peg.4015
Escherichia coli NC101 (1-448/451)
M
MSA
P
K
IT
F
IG
A
GST
I
FV
KN
ILG
D
V
FHREA
L
K
TAH
I
A
L
M
D
I
D
PT
R
LEESH
I
--V
V
R
K
L
MD
S
AG
ASG
K
ITC
H
T
Q
Q
K
EAL
Q
DADFV
VVAF
QI
G
G
Y
E
P
C
TVT
D
F
E
VCK
RHG
-
L
E
Q
TIAD
T
L
GPGGI
MR
A
LRTIP
H
L
W
QI
C
E
DM
T
E
V
CP
D
A
T
MLNY
V
NP
M
AM
N
T
W
A
M
Y
A
RY
P
HI
K
Q
V
GLCH
S
VQ
G
TAEE
L
A
RD
L
N
I
-
D
PAT
LR
Y
R
CA
G
I
NHM
AFYLE
L
E
R
KTAD
G
S
YV
N
L
Y
PELL
--
-
-
--------------
A
AYEA
GQA
PK
PN
I
HG-
-----------
--
NT
RC
Q
N
IV
R
Y
E
M
F
K
K
L
G
YFVT
E
SS
EH
F-
A
EYTPW
F
I
K
PG
RED
L
I
E
R
YK
V
P
LDEYPKRCVE
Q
L
ANWH
KELE
EYKN
A
SRI
D
I
KPSREY
A
S
TI
M
NAI
W
T
--------
G
E
P
S
VI
Y
G
N
----------------
V
R
N
D
G
L
IDN
L
P
QGCC
VE
V
A
C
L
V
D
A
NG
IQ
P
T
-
----
K
A
GT
L
PSHLA
A
LM
Q
T
NIN
V
Q
T
L
LT
E
A
I
L
TENRDR
V
YH
A
AM
MD
P
HTA
A
V
L
G
IDE
I
Y
AL
V
D
D
LI
A
AH
GD
WLP
GW
fig|685038.3.peg.4221
Escherichia coli O83:H1 str. NRG 857C (1-448/451)
M
MSA
P
K
IT
F
IG
A
GST
I
FV
KN
ILG
D
V
FHREA
L
K
TAH
I
A
L
M
D
I
D
PT
R
LEESH
I
--V
V
R
K
L
MD
S
AG
ASG
K
ITC
H
T
Q
Q
K
EAL
Q
DADFV
VVAF
QI
G
G
Y
E
P
C
TVT
D
F
E
VCK
RHG
-
L
E
Q
TIAD
T
L
GPGGI
MR
A
LRTIP
H
L
W
QI
C
E
DM
T
E
V
CP
D
A
T
MLNY
V
NP
M
AM
N
T
W
A
M
Y
A
RY
P
HI
K
Q
V
GLCH
S
VQ
G
TAEE
L
A
RD
L
N
I
-
D
PAT
LR
Y
R
CA
G
I
NHM
AFYLE
L
E
R
KTAD
G
S
YV
N
L
Y
PELL
--
-
-
--------------
A
AYEA
GQA
PK
PN
I
HG-
-----------
--
NT
RC
Q
N
IV
R
Y
E
M
F
K
K
L
G
YFVT
E
SS
EH
F-
A
EYTPW
F
I
K
PG
RED
L
I
E
R
YK
V
P
LDEYPKRCVE
Q
L
ANWH
KELE
EYKN
A
SRI
D
I
KPSREY
A
S
TI
M
NAI
W
T
--------
G
E
P
S
VI
Y
G
N
----------------
V
R
N
D
G
L
IDN
L
P
QGCC
VE
V
A
C
L
V
D
A
NG
IQ
P
T
-
----
K
A
GT
L
PSHLA
A
LM
Q
T
NIN
V
Q
T
L
LT
E
A
I
L
TENRDR
V
YH
A
AM
MD
P
HTA
A
V
L
G
IDE
I
Y
AL
V
D
D
LI
A
AH
GD
WLP
GW
fig|585035.6.peg.4521
Escherichia coli S88 (1-448/451)
M
MSA
P
K
IT
F
IG
A
GST
I
FV
KN
ILG
D
V
FHREA
L
K
TAH
I
A
L
M
D
I
D
PT
R
LEESH
I
--V
V
R
K
L
MD
S
AG
ASG
K
ITC
H
T
Q
Q
K
EAL
Q
DADFV
VVAF
QI
G
G
Y
E
P
C
TVT
D
F
E
VCK
RHG
-
L
E
Q
TIAD
T
L
GPGGI
MR
A
LRTIP
H
L
W
QI
C
E
DM
T
E
V
CP
D
A
T
MLNY
V
NP
M
AM
N
T
W
A
M
Y
A
RY
P
HI
K
Q
V
GLCH
S
VQ
G
TAEE
L
A
RD
L
N
I
-
D
PAT
LR
Y
R
CA
G
I
NHM
AFYLE
L
E
R
KTAD
G
S
YV
N
L
Y
PELL
--
-
-
--------------
A
AYEA
GQA
PK
PN
I
HG-
-----------
--
NT
RC
Q
N
IV
R
Y
E
M
F
K
K
L
G
YFVT
E
SS
EH
F-
A
EYTPW
F
I
K
PG
RED
L
I
E
R
YK
V
P
LDEYPKRCVE
Q
L
ANWH
KELE
EYKN
A
SRI
D
I
KPSREY
A
S
TI
M
NAI
W
T
--------
G
E
P
S
VI
Y
G
N
----------------
V
R
N
D
G
L
IDN
L
P
QGCC
VE
V
A
C
L
V
D
A
NG
IQ
P
T
-
----
K
A
GT
L
PSHLA
A
LM
Q
T
NIN
V
Q
T
L
LT
E
A
I
L
TENRDR
V
YH
A
AM
MD
P
HTA
A
V
L
G
IDE
I
Y
AL
V
D
D
LI
A
AH
GD
WLP
GW
fig|656440.3.peg.4692
Escherichia coli TA206 (1-448/451)
M
MSA
P
K
IT
F
IG
A
GST
I
FV
KN
ILG
D
V
FHREA
L
K
TAH
I
A
L
M
D
I
D
PT
R
LEESH
I
--V
V
R
K
L
MD
S
AG
ASG
K
ITC
H
T
Q
Q
K
EAL
Q
DADFV
VVAF
QI
G
G
Y
E
P
C
TVT
D
F
E
VCK
RHG
-
L
E
Q
TIAD
T
L
GPGGI
MR
A
LRTIP
H
L
W
QI
C
E
DM
T
E
V
CP
D
A
T
MLNY
V
NP
M
AM
N
T
W
A
M
Y
A
RY
P
HI
K
Q
V
GLCH
S
VQ
G
TAEE
L
A
RD
L
N
I
-
D
PAT
LR
Y
R
CA
G
I
NHM
AFYLE
L
E
R
KTAD
G
S
YV
N
L
Y
PELL
--
-
-
--------------
A
AYEA
GQA
PK
PN
I
HG-
-----------
--
NT
RC
Q
N
IV
R
Y
E
M
F
K
K
L
G
YFVT
E
SS
EH
F-
A
EYTPW
F
I
K
PG
RED
L
I
E
R
YK
V
P
LDEYPKRCVE
Q
L
ANWH
KELE
EYKN
A
SRI
D
I
KPSREY
A
S
TI
M
NAI
W
T
--------
G
E
P
S
VI
Y
G
N
----------------
V
R
N
D
G
L
IDN
L
P
QGCC
VE
V
A
C
L
V
D
A
NG
IQ
P
T
-
----
K
A
GT
L
PSHLA
A
LM
Q
T
NIN
V
Q
T
L
LT
E
A
I
L
TENRDR
V
YH
A
AM
MD
P
HTA
A
V
L
G
IDE
I
Y
AL
V
D
D
LI
A
AH
GD
WLP
GW
fig|869729.3.peg.4472
Escherichia coli UM146 (1-448/451)
M
MSA
P
K
IT
F
IG
A
GST
I
FV
KN
ILG
D
V
FHREA
L
K
TAH
I
A
L
M
D
I
D
PT
R
LEESH
I
--V
V
R
K
L
MD
S
AG
ASG
K
ITC
H
T
Q
Q
K
EAL
Q
DADFV
VVAF
QI
G
G
Y
E
P
C
TVT
D
F
E
VCK
RHG
-
L
E
Q
TIAD
T
L
GPGGI
MR
A
LRTIP
H
L
W
QI
C
E
DM
T
E
V
CP
D
A
T
MLNY
V
NP
M
AM
N
T
W
A
M
Y
A
RY
P
HI
K
Q
V
GLCH
S
VQ
G
TAEE
L
A
RD
L
N
I
-
D
PAT
LR
Y
R
CA
G
I
NHM
AFYLE
L
E
R
KTAD
G
S
YV
N
L
Y
PELL
--
-
-
--------------
A
AYEA
GQA
PK
PN
I
HG-
-----------
--
NT
RC
Q
N
IV
R
Y
E
M
F
K
K
L
G
YFVT
E
SS
EH
F-
A
EYTPW
F
I
K
PG
RED
L
I
E
R
YK
V
P
LDEYPKRCVE
Q
L
ANWH
KELE
EYKN
A
SRI
D
I
KPSREY
A
S
TI
M
NAI
W
T
--------
G
E
P
S
VI
Y
G
N
----------------
V
R
N
D
G
L
IDN
L
P
QGCC
VE
V
A
C
L
V
D
A
NG
IQ
P
T
-
----
K
A
GT
L
PSHLA
A
LM
Q
T
NIN
V
Q
T
L
LT
E
A
I
L
TENRDR
V
YH
A
AM
MD
P
HTA
A
V
L
G
IDE
I
Y
AL
V
D
D
LI
A
AH
GD
WLP
GW
fig|364106.7.peg.4595
Escherichia coli UTI89 (1-448/451)
M
MSA
P
K
IT
F
IG
A
GST
I
FV
KN
ILG
D
V
FHREA
L
K
TAH
I
A
L
M
D
I
D
PT
R
LEESH
I
--V
V
R
K
L
MD
S
AG
ASG
K
ITC
H
T
Q
Q
K
EAL
Q
DADFV
VVAF
QI
G
G
Y
E
P
C
TVT
D
F
E
VCK
RHG
-
L
E
Q
TIAD
T
L
GPGGI
MR
A
LRTIP
H
L
W
QI
C
E
DM
T
E
V
CP
D
A
T
MLNY
V
NP
M
AM
N
T
W
A
M
Y
A
RY
P
HI
K
Q
V
GLCH
S
VQ
G
TAEE
L
A
RD
L
N
I
-
D
PAT
LR
Y
R
CA
G
I
NHM
AFYLE
L
E
R
KTAD
G
S
YV
N
L
Y
PELL
--
-
-
--------------
A
AYEA
GQA
PK
PN
I
HG-
-----------
--
NT
RC
Q
N
IV
R
Y
E
M
F
K
K
L
G
YFVT
E
SS
EH
F-
A
EYTPW
F
I
K
PG
RED
L
I
E
R
YK
V
P
LDEYPKRCVE
Q
L
ANWH
KELE
EYKN
A
SRI
D
I
KPSREY
A
S
TI
M
NAI
W
T
--------
G
E
P
S
VI
Y
G
N
----------------
V
R
N
D
G
L
IDN
L
P
QGCC
VE
V
A
C
L
V
D
A
NG
IQ
P
T
-
----
K
A
GT
L
PSHLA
A
LM
Q
T
NIN
V
Q
T
L
LT
E
A
I
L
TENRDR
V
YH
A
AM
MD
P
HTA
A
V
L
G
IDE
I
Y
AL
V
D
D
LI
A
AH
GD
WLP
GW
fig|364106.8.peg.4594
Escherichia coli UTI89 (1-448/451)
M
MSA
P
K
IT
F
IG
A
GST
I
FV
KN
ILG
D
V
FHREA
L
K
TAH
I
A
L
M
D
I
D
PT
R
LEESH
I
--V
V
R
K
L
MD
S
AG
ASG
K
ITC
H
T
Q
Q
K
EAL
Q
DADFV
VVAF
QI
G
G
Y
E
P
C
TVT
D
F
E
VCK
RHG
-
L
E
Q
TIAD
T
L
GPGGI
MR
A
LRTIP
H
L
W
QI
C
E
DM
T
E
V
CP
D
A
T
MLNY
V
NP
M
AM
N
T
W
A
M
Y
A
RY
P
HI
K
Q
V
GLCH
S
VQ
G
TAEE
L
A
RD
L
N
I
-
D
PAT
LR
Y
R
CA
G
I
NHM
AFYLE
L
E
R
KTAD
G
S
YV
N
L
Y
PELL
--
-
-
--------------
A
AYEA
GQA
PK
PN
I
HG-
-----------
--
NT
RC
Q
N
IV
R
Y
E
M
F
K
K
L
G
YFVT
E
SS
EH
F-
A
EYTPW
F
I
K
PG
RED
L
I
E
R
YK
V
P
LDEYPKRCVE
Q
L
ANWH
KELE
EYKN
A
SRI
D
I
KPSREY
A
S
TI
M
NAI
W
T
--------
G
E
P
S
VI
Y
G
N
----------------
V
R
N
D
G
L
IDN
L
P
QGCC
VE
V
A
C
L
V
D
A
NG
IQ
P
T
-
----
K
A
GT
L
PSHLA
A
LM
Q
T
NIN
V
Q
T
L
LT
E
A
I
L
TENRDR
V
YH
A
AM
MD
P
HTA
A
V
L
G
IDE
I
Y
AL
V
D
D
LI
A
AH
GD
WLP
GW
fig|701177.3.peg.4951
Escherichia coli O55:H7 str. CB9615 (1-448/451)
M
MSA
P
K
IT
F
IG
A
GST
I
FV
KN
ILG
D
V
FHREA
L
K
TAH
I
A
L
M
D
I
D
PT
R
LEESH
I
--V
V
R
K
L
MD
S
AG
ASG
K
ITC
H
T
Q
Q
K
EAL
Q
DADFV
VVAF
QI
G
G
Y
A
P
C
TVT
D
F
E
VCK
R
Y
G
-
L
E
Q
TIAD
T
L
GPGGI
MR
A
LRTIP
H
L
W
QI
C
E
D
I
T
E
V
CP
D
A
T
MLNY
V
NP
M
AM
N
T
W
A
M
Y
A
RY
P
HI
K
Q
V
GLCH
S
VQ
G
TAEE
L
A
RD
L
N
I
-
D
PAT
LR
Y
R
CA
G
I
NHM
AFYLE
L
E
R
KTAD
G
S
YV
N
L
Y
PELL
--
-
-
--------------
A
AYDA
GQA
PK
PN
I
HG-
-----------
--
NT
RC
Q
N
IV
R
Y
E
M
F
K
K
L
G
YFVT
E
SS
EH
F-
A
EYTPW
F
I
K
PG
RED
L
I
E
R
YK
V
P
LDEYPKRCVE
Q
L
ANWH
KELE
EYKN
A
SRI
D
I
KPSREY
A
S
TI
M
NAI
W
T
--------
G
E
P
S
VI
Y
G
N
----------------
V
R
N
D
G
L
IDN
L
P
QGCC
VE
V
A
C
L
V
D
A
NG
IQ
P
T
-
----
K
V
GT
L
PSHLA
A
LM
Q
T
NIN
V
Q
T
L
LT
E
A
I
L
TENRDR
V
YH
A
AM
MD
P
HTA
A
V
L
G
IDE
I
Y
AL
V
D
D
LI
A
AH
GD
WLP
GW
fig|749527.3.peg.5038
Escherichia coli MS 21-1 (1-448/451)
M
MSA
P
K
IT
F
IG
A
GST
I
FV
KN
ILG
D
V
FHREA
L
K
TAH
I
A
L
M
D
I
D
PT
R
LEESH
I
--V
V
R
K
L
MD
S
AG
ASG
K
ITC
H
T
Q
Q
K
EAL
Q
DADFV
VVAF
QI
G
G
Y
E
P
C
TVT
D
F
E
VCK
RHG
-
L
E
Q
TIAD
T
L
GPGGI
MR
A
LRTIP
H
L
W
QI
C
E
DM
T
E
V
CP
D
A
T
MLNY
V
NP
M
AM
N
T
W
A
M
Y
A
RY
P
HI
K
Q
V
GLCH
S
VQ
G
TAEE
L
A
RD
L
N
I
-
D
PAT
LR
Y
R
CA
G
I
NHM
AFYLE
L
E
R
KTAD
G
S
YV
N
L
Y
PELL
--
-
-
--------------
V
AYEA
GQA
PK
PN
I
HG-
-----------
--
NT
RC
Q
N
IV
R
Y
E
M
F
K
K
L
G
YFVT
E
SS
EH
F-
A
EYTPW
F
I
K
PG
RED
L
I
E
R
YK
V
P
LDEYPKRCVE
Q
L
ANWH
KELE
EYKN
A
SRI
D
I
KPSREY
A
S
TI
M
NAI
W
T
--------
G
E
P
S
VI
Y
G
N
----------------
V
R
N
D
G
L
IDN
L
P
QGCC
VE
V
A
C
L
V
D
A
NG
IQ
P
T
-
----
K
A
GT
L
PSHLA
A
LM
Q
T
NIN
V
Q
T
L
LT
E
A
I
L
TENRDR
V
YH
A
AM
MD
P
HTA
A
V
L
G
IDE
I
Y
AL
V
D
D
LI
A
AH
GD
WLP
GW
fig|656379.3.peg.492
Escherichia coli FVEC1302 (1-448/451)
M
MSA
P
K
IT
F
IG
A
GST
I
FV
KN
ILG
D
V
FHREA
L
K
TAH
I
A
L
M
D
I
D
PT
R
LEESH
I
--V
V
R
K
L
MD
S
AG
ASG
K
ITC
H
T
Q
Q
K
EAL
Q
DADFV
VVAF
QI
G
G
Y
E
P
C
TVT
D
F
E
VCK
RHG
-
L
E
Q
TIAD
T
L
GPGGI
MR
A
LRTIP
H
L
W
QI
C
E
DM
T
E
V
CP
D
A
T
MLNY
V
NP
M
AM
N
T
W
A
M
Y
A
RY
P
HI
K
Q
V
GLCH
S
VQ
G
TAEE
L
A
RD
L
N
I
-
D
PAT
LR
Y
R
CA
G
I
NHM
AFYLE
L
E
R
KTAD
G
S
YV
N
L
Y
PELL
--
-
-
--------------
A
AYEA
GQA
PK
PN
I
HG-
-----------
--
NT
RC
Q
N
IV
R
Y
E
M
F
K
K
L
G
YFVT
E
SS
EH
F-
A
EYTPW
F
I
K
PG
RED
L
I
E
R
YK
V
P
LDEYPKRCVE
Q
L
ANWH
KELE
EYKN
A
SRI
D
I
KPSREY
A
S
TI
M
NAI
W
T
--------
G
E
P
S
VI
Y
G
N
----------------
V
R
N
DD
L
IDN
L
P
QGCC
VE
V
A
C
L
V
D
A
NG
IQ
P
T
-
----
K
V
GT
L
PSHLA
A
LM
Q
T
NIN
V
Q
T
L
LT
E
A
I
L
TENRDR
V
YH
A
AM
MD
P
HTA
A
V
L
G
IDE
I
Y
AL
V
D
D
LI
A
AH
GD
WLP
GW
fig|656380.3.peg.484
Escherichia coli FVEC1412 (1-448/451)
M
MSA
P
K
IT
F
IG
A
GST
I
FV
KN
ILG
D
V
FHREA
L
K
TAH
I
A
L
M
D
I
D
PT
R
LEESH
I
--V
V
R
K
L
MD
S
AG
ASG
K
ITC
H
T
Q
Q
K
EAL
Q
DADFV
VVAF
QI
G
G
Y
E
P
C
TVT
D
F
E
VCK
RHG
-
L
E
Q
TIAD
T
L
GPGGI
MR
A
LRTIP
H
L
W
QI
C
E
DM
T
E
V
CP
D
A
T
MLNY
V
NP
M
AM
N
T
W
A
M
Y
A
RY
P
HI
K
Q
V
GLCH
S
VQ
G
TAEE
L
A
RD
L
N
I
-
D
PAT
LR
Y
R
CA
G
I
NHM
AFYLE
L
E
R
KTAD
G
S
YV
N
L
Y
PELL
--
-
-
--------------
A
AYEA
GQA
PK
PN
I
HG-
-----------
--
NT
RC
Q
N
IV
R
Y
E
M
F
K
K
L
G
YFVT
E
SS
EH
F-
A
EYTPW
F
I
K
PG
RED
L
I
E
R
YK
V
P
LDEYPKRCVE
Q
L
ANWH
KELE
EYKN
A
SRI
D
I
KPSREY
A
S
TI
M
NAI
W
T
--------
G
E
P
S
VI
Y
G
N
----------------
V
R
N
DD
L
IDN
L
P
QGCC
VE
V
A
C
L
V
D
A
NG
IQ
P
T
-
----
K
V
GT
L
PSHLA
A
LM
Q
T
NIN
V
Q
T
L
LT
E
A
I
L
TENRDR
V
YH
A
AM
MD
P
HTA
A
V
L
G
IDE
I
Y
AL
V
D
D
LI
A
AH
GD
WLP
GW
fig|749549.3.peg.1649
Escherichia coli MS 198-1 (1-448/451)
M
MSA
P
K
IT
F
IG
A
GST
I
FV
KN
ILG
D
V
FHREA
L
K
TAH
I
A
L
M
D
I
D
PT
R
LEESH
I
--V
V
R
K
L
MD
S
AG
ASG
K
ITC
H
T
Q
Q
K
EAL
Q
DADFV
VVAF
QI
G
G
Y
E
P
C
TVT
D
F
E
VCK
RHG
-
L
E
Q
TIAD
T
L
GPGGI
MR
A
LRTIP
H
L
W
QI
C
E
DM
T
E
V
CP
D
A
T
MLNY
V
NP
M
AM
N
T
W
A
M
Y
A
RY
P
HI
K
Q
V
GLCH
S
VQ
G
TAEE
L
A
RD
L
N
I
-
D
PAT
LR
Y
R
CA
G
I
NHM
AFYLE
L
E
R
KTAD
G
S
YV
N
L
Y
PELL
--
-
-
--------------
A
AYEA
GQA
PK
PN
I
HG-
-----------
--
NT
RC
Q
N
IV
R
Y
E
M
F
K
K
L
G
YFVT
E
SS
EH
F-
A
EYTPW
F
I
K
PG
RED
L
I
E
R
YK
V
P
LDEYPKRCVE
Q
L
ANWH
KELE
EYKN
A
SRI
D
I
KPSREY
A
S
TI
M
NAI
W
T
--------
G
E
P
S
VI
Y
G
N
----------------
V
R
N
DD
L
IDN
L
P
QGCC
VE
V
A
C
L
V
D
A
NG
IQ
P
T
-
----
K
V
GT
L
PSHLA
A
LM
Q
T
NIN
V
Q
T
L
LT
E
A
I
L
TENRDR
V
YH
A
AM
MD
P
HTA
A
V
L
G
IDE
I
Y
AL
V
D
D
LI
A
AH
GD
WLP
GW
fig|585056.7.peg.4815
Escherichia coli UMN026 (1-448/451)
M
MSA
P
K
IT
F
IG
A
GST
I
FV
KN
ILG
D
V
FHREA
L
K
TAH
I
A
L
M
D
I
D
PT
R
LEESH
I
--V
V
R
K
L
MD
S
AG
ASG
K
ITC
H
T
Q
Q
K
EAL
Q
DADFV
VVAF
QI
G
G
Y
E
P
C
TVT
D
F
E
VCK
RHG
-
L
E
Q
TIAD
T
L
GPGGI
MR
A
LRTIP
H
L
W
QI
C
E
DM
T
E
V
CP
D
A
T
MLNY
V
NP
M
AM
N
T
W
A
M
Y
A
RY
P
HI
K
Q
V
GLCH
S
VQ
G
TAEE
L
A
RD
L
N
I
-
D
PAT
LR
Y
R
CA
G
I
NHM
AFYLE
L
E
R
KTAD
G
S
YV
N
L
Y
PELL
--
-
-
--------------
A
AYEA
GQA
PK
PN
I
HG-
-----------
--
NT
RC
Q
N
IV
R
Y
E
M
F
K
K
L
G
YFVT
E
SS
EH
F-
A
EYTPW
F
I
K
PG
RED
L
I
E
R
YK
V
P
LDEYPKRCVE
Q
L
ANWH
KELE
EYKN
A
SRI
D
I
KPSREY
A
S
TI
M
NAI
W
T
--------
G
E
P
S
VI
Y
G
N
----------------
V
R
N
DD
L
IDN
L
P
QGCC
VE
V
A
C
L
V
D
A
NG
IQ
P
T
-
----
K
V
GT
L
PSHLA
A
LM
Q
T
NIN
V
Q
T
L
LT
E
A
I
L
TENRDR
V
YH
A
AM
MD
P
HTA
A
V
L
G
IDE
I
Y
AL
V
D
D
LI
A
AH
GD
WLP
GW
fig|656444.3.peg.5578
Escherichia coli TA280 (1-448/451)
M
MSA
P
K
IT
F
IG
A
GST
I
FV
KN
ILG
D
V
FHREA
L
K
TAH
I
A
L
M
D
I
D
PT
R
LEESH
I
--V
V
R
K
L
MD
S
AG
ASG
K
ITC
H
T
Q
Q
K
EAL
Q
DADFV
VVAF
QI
G
G
Y
E
P
C
TVT
D
F
E
VCK
RHG
-
L
E
Q
TIAD
T
L
GPGGI
MR
A
LRTIP
H
L
W
QI
C
E
DM
T
E
V
CP
D
A
T
MLNY
V
NP
M
AM
N
T
W
A
M
Y
A
RY
P
HI
K
Q
V
GLCH
S
VQ
G
TAEE
L
A
RD
L
N
I
-
D
PAT
LR
Y
R
CA
G
I
NHM
AFYLE
L
E
R
KTAD
G
I
YV
N
L
Y
PELL
--
-
-
--------------
A
AYEA
GQA
PK
PN
I
HG-
-----------
--
NT
RC
Q
N
IV
R
Y
E
M
F
K
K
L
G
YFVT
E
SS
EH
F-
A
EYTPW
F
I
K
PG
RED
L
I
E
R
YK
V
P
LDEYPKRCVE
Q
L
ANWH
KELE
EYKN
A
SRI
D
I
KPSREY
A
S
TI
M
NAI
W
T
--------
G
E
P
S
VI
Y
G
N
----------------
V
R
N
DD
L
IDN
L
P
QGCC
VE
V
A
C
L
V
D
A
NG
IQ
P
T
-
----
K
V
GT
L
PSHLA
A
LM
Q
T
NIN
V
Q
T
L
LT
E
A
I
L
TENRDR
V
YH
A
AM
MD
P
HTA
A
V
L
G
IDE
I
Y
AL
V
D
D
LI
A
AH
GD
WLP
GW
fig|216592.1.peg.2422
Escherichia coli 042 (1-448/451)
M
MSA
P
K
IT
F
IG
A
GST
I
FV
KN
ILG
D
V
FHREA
L
K
TAH
I
A
L
M
D
I
D
PT
R
LEESH
I
--V
V
R
K
L
MD
S
AG
ASG
K
ITC
H
T
Q
Q
K
EAL
Q
DADFV
VVAF
QI
G
G
Y
E
P
C
TVT
D
F
E
VCK
RHG
-
L
E
Q
TIAD
T
L
GPGGI
MR
A
LRTIP
H
L
W
QI
C
E
DM
T
E
V
CP
D
A
T
MLNY
V
NP
M
AM
N
T
W
A
M
Y
A
RY
P
HI
K
Q
V
GLCH
S
VQ
G
TAEE
L
A
RD
L
N
I
-
D
PAT
LR
Y
R
CA
G
I
NHM
AFYLE
L
E
R
KTAD
G
S
YV
N
L
Y
PELL
--
-
-
--------------
A
AYEA
GQA
PK
PN
I
HG-
-----------
--
NT
RC
Q
N
IV
R
Y
E
M
F
K
K
L
G
YFVT
E
SS
EH
F-
A
EYTPW
F
I
K
PG
RED
L
I
E
R
YK
V
P
LDEYPKRCVE
Q
L
ANWH
KELE
EYKN
A
SRI
D
I
KPSREY
A
S
TI
M
NAI
W
T
--------
G
E
P
S
VI
Y
G
N
----------------
V
R
N
DV
L
IDN
L
P
QGCC
VE
V
A
C
L
V
D
A
NG
IQ
P
T
-
----
K
V
GT
L
PSHLA
A
LM
Q
T
NIN
V
Q
T
L
LT
E
A
I
L
TENRDR
V
YH
A
AM
MD
P
HTA
A
V
L
G
IDE
I
Y
AL
V
D
D
LI
A
AH
GD
WLP
GW
fig|216592.3.peg.4656
Escherichia coli 042 (1-448/451)
M
MSA
P
K
IT
F
IG
A
GST
I
FV
KN
ILG
D
V
FHREA
L
K
TAH
I
A
L
M
D
I
D
PT
R
LEESH
I
--V
V
R
K
L
MD
S
AG
ASG
K
ITC
H
T
Q
Q
K
EAL
Q
DADFV
VVAF
QI
G
G
Y
E
P
C
TVT
D
F
E
VCK
RHG
-
L
E
Q
TIAD
T
L
GPGGI
MR
A
LRTIP
H
L
W
QI
C
E
DM
T
E
V
CP
D
A
T
MLNY
V
NP
M
AM
N
T
W
A
M
Y
A
RY
P
HI
K
Q
V
GLCH
S
VQ
G
TAEE
L
A
RD
L
N
I
-
D
PAT
LR
Y
R
CA
G
I
NHM
AFYLE
L
E
R
KTAD
G
S
YV
N
L
Y
PELL
--
-
-
--------------
A
AYEA
GQA
PK
PN
I
HG-
-----------
--
NT
RC
Q
N
IV
R
Y
E
M
F
K
K
L
G
YFVT
E
SS
EH
F-
A
EYTPW
F
I
K
PG
RED
L
I
E
R
YK
V
P
LDEYPKRCVE
Q
L
ANWH
KELE
EYKN
A
SRI
D
I
KPSREY
A
S
TI
M
NAI
W
T
--------
G
E
P
S
VI
Y
G
N
----------------
V
R
N
DV
L
IDN
L
P
QGCC
VE
V
A
C
L
V
D
A
NG
IQ
P
T
-
----
K
V
GT
L
PSHLA
A
LM
Q
T
NIN
V
Q
T
L
LT
E
A
I
L
TENRDR
V
YH
A
AM
MD
P
HTA
A
V
L
G
IDE
I
Y
AL
V
D
D
LI
A
AH
GD
WLP
GW
fig|656419.3.peg.5366
Escherichia coli M718 (1-448/451)
M
MSA
P
K
IT
F
IG
A
GST
I
FV
KN
ILG
D
V
FHREA
L
K
TAH
I
A
L
M
D
I
D
PT
R
LEESH
I
--V
V
R
K
L
MD
S
AG
ASG
K
ITC
H
T
Q
Q
K
EAL
Q
DADFV
VVAF
QI
G
G
Y
E
P
C
TVT
D
F
E
VCK
RHG
-
L
E
Q
TIAD
T
L
GPGGI
MR
A
LRTIP
H
L
W
QI
C
E
DM
T
E
V
C
S
D
A
T
MLNY
V
NP
M
AM
N
T
W
A
M
Y
A
RY
P
HI
K
Q
V
GLCH
S
VQ
G
TAEE
L
A
RD
L
N
I
-
D
PAT
LR
Y
R
CA
G
I
NHM
AFYLE
L
E
R
KTAD
G
S
YV
N
L
Y
PELL
--
-
-
--------------
A
AYDA
GQA
PK
PN
I
HG-
-----------
--
NT
RC
Q
N
IV
R
Y
E
M
F
K
K
L
G
YFVT
E
SS
EH
F-
A
EYTPW
F
I
K
PG
RED
L
I
E
R
YK
V
P
LDEYPKRCVE
Q
L
ANWH
KELE
EYKN
A
SRI
D
I
KPSREY
A
S
TI
M
NAI
W
T
--------
G
E
P
S
VI
Y
G
N
----------------
V
R
N
D
G
L
IDN
L
P
QGCC
VE
V
A
C
L
V
D
A
NG
IQ
P
T
-
----
K
V
GT
L
PSHLA
A
LM
Q
T
NIN
V
Q
T
L
LT
E
A
I
L
TENRDR
V
YH
A
AM
MD
P
HTA
A
V
L
G
IDE
I
Y
AL
V
D
D
LI
A
AH
GD
WLP
GW
Consen1
Primary consensus
Msqk
kvv
iGgGSt
tp
ilg
i
lp
l
l
D
d
r
I
cq
mmd
ag
k
ttd
reAl
DaDFV
rvG
y
-
P
relDeriplrHG
lgQ
---
eT
GpGGi
glRtIp
i
qivkdmee
cPnAwmlNy
NPaamvteA
yr
p
k
iglCh
piG
ia
l
l
D
lr
r
GlNHm
ied
G
--
sl
peLl
v
--------------
a
gqaka
v
-----------
ntlp
syl
Yy
f
k
-
e
Eh
a
viq
ekqlfe
yk
p
----------
l
kele
a
d
------
Ac
inAi
n
--------
de
a
yvn
----------------
vpnhG
IdN
p
VEm
C
vg
nG
P
p
----
i
f
gLm
t
ve
l
nA
l
v
A
lsp
---
V
s
a
al
deli
Ah
wlP
ADCIAELKKAH
Consen2
Secondary consensus
msa
sit
a
a
s
fv
em
fk
i
f
e
k
v
k
ka
a
hlq
v
f
v
qi
le
tvt
f
vcks
ve
tiad
a
l
am
s
g
lc
yvtk
s
d
tvi
f
mginaw
ra
g
r
n
vq
r
v
i
ms
d
i
f
lkr
yv
r
aq
r
-
khgyvppqqdthte
-
tylpk
i
fdlpfseglir
dlrc
iv
e
k
d
g
s
y
g
f
redvid
--
-
ldeypkrcve
-
----
-
-
kpsrey
s
mt
a
tsaagkleigk
s
igdlaaaiafntqermlliirh
h
d
ld
d
-
lvvg
v
l
a
i
q
fq
a
e
l
mdkhta
g
i
li
rdml
n
yw
Consensus 1
(when a gap)
Conservative difference
Consensus 2
(when a gap)
Nonconservative diff.
Other character