fig|1040638.4.peg.3761
Escherichia coli O104:H4 str. LB226692
MKVTLTFNEQRRAAYR
QQ
G
L
W
G
D
AS
LAD
YW
-
QQ
TA
R
A
MP
D
K
IAVVD
NH
G
AS
Y
T
Y
S
A
L
DH
AA
S
C
LAN
WMLAK
GI
E
S
GD
RI
A
F
QL
P
G
WC
EF
TVI
Y
L
A
C
LKIGA
VS
VP
L
L
P
S
WR
E
A
EL
V
W
V
L
NKC
QA
KMFFAP
T
----
LFK
Q
T
R
P
VD
LI
LPL
Q
NQ
L
P
QL
QQ
I
VGV
D
KLAP
A
T
SS
L
-
S
LS
Q
I
I
A
D
----------
N
T
P
L
T
--
TA
I
T
THG
DE
L
A
AV
LFTSGT
E
G
L
PKGV
ML
THNN
ILA
S
E
R
A
Y
CAR
L
N
LT
W
QDV
FM
MPA
P
L
G
H
ATGFLH
G
VT
AP
-----
FL
I
GA
R
S
VL
LDIF
TP
D
AC
LA
L
L
E
Q
Q
R
C
T
C
M
LGA
T
P
F
V
-
Y
D
L
L
N
L
L
E--
K
QP
A
D
L
SA
L
R
F
F
L
C
GG
TT
IP
KKV-
AR
E
C
Q
Q
R
G
I
K
LL
S
VYG
S
TE
SSP
HA
V
VN
---
LDDP
LS
R
----
F
M
HT
D
GY
AA
-
AGV
E
IK
V
V
DD
ARK
T
LP
P
G
C
E
GE
EAS
R
---
GP
NV
F
M
GYF
DE
P
E
L
TA
R
ALD
E
E
GWY
Y
SGDL
CRM
DE
A
GYI
KIT
GR
K
KD
I
I
V
RGGENIS
SR
E
V
E
D
ILL
Q
HPKI
H
DA
C
VV
A
M
P
DE
RL
GE
R
SCAYVVLK
A
P
H
HS
LS
L
EEV
V
A
F
FS
RK
R
V
AK
Y
K
Y
P
EH
I
V
VI
E
K
LPRT
A
SGKI
Q
K
F
L
LR
KDIMR
RLTQDVCEEIE
fig|6666666.5357.peg.2468
Escherichia coli TY-2482
MKVTLTFNEQRRAAYR
QQ
G
L
W
G
D
AS
LAD
YW
-
QQ
TA
R
A
MP
D
K
IAVVD
NH
G
AS
Y
T
Y
S
A
L
DH
AA
S
C
LAN
WMLAK
GI
E
S
GD
RI
A
F
QL
P
G
WC
EF
TVI
Y
L
A
C
LKIGA
VS
VP
L
L
P
S
WR
E
A
EL
V
W
V
L
NKC
QA
KMFFAP
T
----
LFK
Q
T
R
P
VD
LI
LPL
Q
NQ
L
P
QL
QQ
I
VGV
D
KLAP
A
T
SS
L
-
S
LS
Q
I
I
A
D
----------
N
T
P
L
T
--
TA
I
T
THG
DE
L
A
AV
LFTSGT
E
G
L
PKGV
ML
THNN
ILA
S
E
R
A
Y
CAR
L
N
LT
W
QDV
FM
MPA
P
L
G
H
ATGFLH
G
VT
AP
-----
FL
I
GA
R
S
VL
LDIF
TP
D
AC
LA
L
L
E
Q
Q
R
C
T
C
M
LGA
T
P
F
V
-
Y
D
L
L
N
L
L
E--
K
QP
A
D
L
SA
L
R
F
F
L
C
GG
TT
IP
KKV-
AR
E
C
Q
Q
R
G
I
K
LL
S
VYG
S
TE
SSP
HA
V
VN
---
LDDP
LS
R
----
F
M
HT
D
GY
AA
-
AGV
E
IK
V
V
DD
ARK
T
LP
P
G
C
E
GE
EAS
R
---
GP
NV
F
M
GYF
DE
P
E
L
TA
R
ALD
E
E
GWY
Y
SGDL
CRM
DE
A
GYI
KIT
GR
K
KD
I
I
V
RGGENIS
SR
E
V
E
D
ILL
Q
HPKI
H
DA
C
VV
A
M
P
DE
RL
GE
R
SCAYVVLK
A
P
H
HS
LS
L
EEV
V
A
F
FS
RK
R
V
AK
Y
K
Y
P
EH
I
V
VI
E
K
LPRT
A
SGKI
Q
K
F
L
LR
KDIMR
RLTQDVCEEIE
fig|344610.3.peg.2443
Escherichia coli 53638
MKVTLTFNEQRRAAYR
QQ
G
L
W
G
D
AS
LAD
YW
-
QQ
TA
R
A
MP
D
K
IAVVD
NH
G
AS
Y
T
Y
S
A
L
DH
AA
S
C
LAN
WMLAK
GI
E
S
GD
RI
A
F
QL
P
G
WC
EF
TVI
Y
L
A
C
LKIGA
VS
VP
L
L
P
S
WR
E
A
EL
V
W
V
L
NKC
QA
KMFFAP
T
----
LFK
Q
T
R
P
VD
LI
LPL
Q
NQ
L
P
QL
QQ
I
VGV
D
KLAP
A
T
SS
L
-
S
LS
Q
I
I
A
D
----------
N
T
P
L
T
--
TA
I
T
THG
DE
L
A
AV
LFTSGT
E
G
L
PKGV
ML
THNN
ILA
S
E
R
A
Y
CAR
L
N
LT
W
QDV
FM
MPA
P
L
G
H
ATGFLH
G
VT
AP
-----
FL
I
GA
R
S
VL
LDIF
TP
D
AC
LA
L
L
E
Q
Q
R
C
T
C
M
LGA
T
P
F
V
-
Y
D
L
L
N
L
L
E--
K
QP
A
D
L
SA
L
R
F
F
L
C
GG
TT
IP
KKV-
AR
E
C
Q
Q
R
G
I
K
LL
S
VYG
S
TE
SSP
HA
V
VN
---
LDDP
LS
R
----
F
M
HT
D
GY
AA
-
AGV
E
IK
V
V
DD
ARK
T
LP
P
G
C
E
GE
EAS
R
---
GP
NV
F
M
GYF
DE
P
E
L
TA
R
ALD
E
E
GWY
Y
SGDL
CRM
DE
A
GYI
KIT
GR
K
KD
I
I
V
RGGENIS
SR
E
V
E
D
ILL
Q
HPKI
H
DA
C
VV
A
M
P
DE
RL
GE
R
SCAYVVLK
A
P
H
HS
LS
L
EEV
V
A
F
FS
RK
R
V
AK
Y
K
Y
P
EH
I
V
VI
E
K
LPRT
A
SGKI
Q
K
F
L
LR
KDIMR
RLTQDVCEEIE
fig|344610.7.peg.5355
Escherichia coli 53638
MKVTLTFNEQRRAAYR
QQ
G
L
W
G
D
AS
LAD
YW
-
QQ
TA
R
A
MP
D
K
IAVVD
NH
G
AS
Y
T
Y
S
A
L
DH
AA
S
C
LAN
WMLAK
GI
E
S
GD
RI
A
F
QL
P
G
WC
EF
TVI
Y
L
A
C
LKIGA
VS
VP
L
L
P
S
WR
E
A
EL
V
W
V
L
NKC
QA
KMFFAP
T
----
LFK
Q
T
R
P
VD
LI
LPL
Q
NQ
L
P
QL
QQ
I
VGV
D
KLAP
A
T
SS
L
-
S
LS
Q
I
I
A
D
----------
N
T
P
L
T
--
TA
I
T
THG
DE
L
A
AV
LFTSGT
E
G
L
PKGV
ML
THNN
ILA
S
E
R
A
Y
CAR
L
N
LT
W
QDV
FM
MPA
P
L
G
H
ATGFLH
G
VT
AP
-----
FL
I
GA
R
S
VL
LDIF
TP
D
AC
LA
L
L
E
Q
Q
R
C
T
C
M
LGA
T
P
F
V
-
Y
D
L
L
N
L
L
E--
K
QP
A
D
L
SA
L
R
F
F
L
C
GG
TT
IP
KKV-
AR
E
C
Q
Q
R
G
I
K
LL
S
VYG
S
TE
SSP
HA
V
VN
---
LDDP
LS
R
----
F
M
HT
D
GY
AA
-
AGV
E
IK
V
V
DD
ARK
T
LP
P
G
C
E
GE
EAS
R
---
GP
NV
F
M
GYF
DE
P
E
L
TA
R
ALD
E
E
GWY
Y
SGDL
CRM
DE
A
GYI
KIT
GR
K
KD
I
I
V
RGGENIS
SR
E
V
E
D
ILL
Q
HPKI
H
DA
C
VV
A
M
P
DE
RL
GE
R
SCAYVVLK
A
P
H
HS
LS
L
EEV
V
A
F
FS
RK
R
V
AK
Y
K
Y
P
EH
I
V
VI
E
K
LPRT
A
SGKI
Q
K
F
L
LR
KDIMR
RLTQDVCEEIE
fig|585055.6.peg.1898
Escherichia coli 55989
MKVTLTFNEQRRAAYR
QQ
G
L
W
G
D
AS
LAD
YW
-
QQ
TA
R
A
MP
D
K
IAVVD
NH
G
AS
Y
T
Y
S
A
L
DH
AA
S
C
LAN
WMLAK
GI
E
S
GD
RI
A
F
QL
P
G
WC
EF
TVI
Y
L
A
C
LKIGA
VS
VP
L
L
P
S
WR
E
A
EL
V
W
V
L
NKC
QA
KMFFAP
T
----
LFK
Q
T
R
P
VD
LI
LPL
Q
NQ
L
P
QL
QQ
I
VGV
D
KLAP
A
T
SS
L
-
S
LS
Q
I
I
A
D
----------
N
T
P
L
T
--
TA
I
T
THG
DE
L
A
AV
LFTSGT
E
G
L
PKGV
ML
THNN
ILA
S
E
R
A
Y
CAR
L
N
LT
W
QDV
FM
MPA
P
L
G
H
ATGFLH
G
VT
AP
-----
FL
I
GA
R
S
VL
LDIF
TP
D
AC
LA
L
L
E
Q
Q
R
C
T
C
M
LGA
T
P
F
V
-
Y
D
L
L
N
L
L
E--
K
QP
A
D
L
SA
L
R
F
F
L
C
GG
TT
IP
KKV-
AR
E
C
Q
Q
R
G
I
K
LL
S
VYG
S
TE
SSP
HA
V
VN
---
LDDP
LS
R
----
F
M
HT
D
GY
AA
-
AGV
E
IK
V
V
DD
ARK
T
LP
P
G
C
E
GE
EAS
R
---
GP
NV
F
M
GYF
DE
P
E
L
TA
R
ALD
E
E
GWY
Y
SGDL
CRM
DE
A
GYI
KIT
GR
K
KD
I
I
V
RGGENIS
SR
E
V
E
D
ILL
Q
HPKI
H
DA
C
VV
A
M
P
DE
RL
GE
R
SCAYVVLK
A
P
H
HS
LS
L
EEV
V
A
F
FS
RK
R
V
AK
Y
K
Y
P
EH
I
V
VI
E
K
LPRT
A
SGKI
Q
K
F
L
LR
KDIMR
RLTQDVCEEIE
fig|585055.8.peg.1901
Escherichia coli 55989
MKVTLTFNEQRRAAYR
QQ
G
L
W
G
D
AS
LAD
YW
-
QQ
TA
R
A
MP
D
K
IAVVD
NH
G
AS
Y
T
Y
S
A
L
DH
AA
S
C
LAN
WMLAK
GI
E
S
GD
RI
A
F
QL
P
G
WC
EF
TVI
Y
L
A
C
LKIGA
VS
VP
L
L
P
S
WR
E
A
EL
V
W
V
L
NKC
QA
KMFFAP
T
----
LFK
Q
T
R
P
VD
LI
LPL
Q
NQ
L
P
QL
QQ
I
VGV
D
KLAP
A
T
SS
L
-
S
LS
Q
I
I
A
D
----------
N
T
P
L
T
--
TA
I
T
THG
DE
L
A
AV
LFTSGT
E
G
L
PKGV
ML
THNN
ILA
S
E
R
A
Y
CAR
L
N
LT
W
QDV
FM
MPA
P
L
G
H
ATGFLH
G
VT
AP
-----
FL
I
GA
R
S
VL
LDIF
TP
D
AC
LA
L
L
E
Q
Q
R
C
T
C
M
LGA
T
P
F
V
-
Y
D
L
L
N
L
L
E--
K
QP
A
D
L
SA
L
R
F
F
L
C
GG
TT
IP
KKV-
AR
E
C
Q
Q
R
G
I
K
LL
S
VYG
S
TE
SSP
HA
V
VN
---
LDDP
LS
R
----
F
M
HT
D
GY
AA
-
AGV
E
IK
V
V
DD
ARK
T
LP
P
G
C
E
GE
EAS
R
---
GP
NV
F
M
GYF
DE
P
E
L
TA
R
ALD
E
E
GWY
Y
SGDL
CRM
DE
A
GYI
KIT
GR
K
KD
I
I
V
RGGENIS
SR
E
V
E
D
ILL
Q
HPKI
H
DA
C
VV
A
M
P
DE
RL
GE
R
SCAYVVLK
A
P
H
HS
LS
L
EEV
V
A
F
FS
RK
R
V
AK
Y
K
Y
P
EH
I
V
VI
E
K
LPRT
A
SGKI
Q
K
F
L
LR
KDIMR
RLTQDVCEEIE
fig|481805.3.peg.2082
Escherichia coli ATCC 8739
MKVTLTFNEQRRAAYR
QQ
G
L
W
G
D
AS
LAD
YW
-
QQ
TA
R
A
MP
D
K
IAVVD
NH
G
AS
Y
T
Y
S
A
L
DH
AA
S
C
LAN
WMLAK
GI
E
S
GD
RI
A
F
QL
P
G
WC
EF
TVI
Y
L
A
C
LKIGA
VS
VP
L
L
P
S
WR
E
A
EL
V
W
V
L
NKC
QA
KMFFAP
T
----
LFK
Q
T
R
P
VD
LI
LPL
Q
NQ
L
P
QL
QQ
I
VGV
D
KLAP
A
T
SS
L
-
S
LS
Q
I
I
A
D
----------
N
T
P
L
T
--
TA
I
T
THG
DE
L
A
AV
LFTSGT
E
G
L
PKGV
ML
THNN
ILA
S
E
R
A
Y
CAR
L
N
LT
W
QDV
FM
MPA
P
L
G
H
ATGFLH
G
VT
AP
-----
FL
I
GA
R
S
VL
LDIF
TP
D
AC
LA
L
L
E
Q
Q
R
C
T
C
M
LGA
T
P
F
V
-
Y
D
L
L
N
L
L
E--
K
QP
A
D
L
SA
L
R
F
F
L
C
GG
TT
IP
KKV-
AR
E
C
Q
Q
R
G
I
K
LL
S
VYG
S
TE
SSP
HA
V
VN
---
LDDP
LS
R
----
F
M
HT
D
GY
AA
-
AGV
E
IK
V
V
DD
ARK
T
LP
P
G
C
E
GE
EAS
R
---
GP
NV
F
M
GYF
DE
P
E
L
TA
R
ALD
E
E
GWY
Y
SGDL
CRM
DE
A
GYI
KIT
GR
K
KD
I
I
V
RGGENIS
SR
E
V
E
D
ILL
Q
HPKI
H
DA
C
VV
A
M
P
DE
RL
GE
R
SCAYVVLK
A
P
H
HS
LS
L
EEV
V
A
F
FS
RK
R
V
AK
Y
K
Y
P
EH
I
V
VI
E
K
LPRT
A
SGKI
Q
K
F
L
LR
KDIMR
RLTQDVCEEIE
fig|481805.6.peg.2077
Escherichia coli ATCC 8739
MKVTLTFNEQRRAAYR
QQ
G
L
W
G
D
AS
LAD
YW
-
QQ
TA
R
A
MP
D
K
IAVVD
NH
G
AS
Y
T
Y
S
A
L
DH
AA
S
C
LAN
WMLAK
GI
E
S
GD
RI
A
F
QL
P
G
WC
EF
TVI
Y
L
A
C
LKIGA
VS
VP
L
L
P
S
WR
E
A
EL
V
W
V
L
NKC
QA
KMFFAP
T
----
LFK
Q
T
R
P
VD
LI
LPL
Q
NQ
L
P
QL
QQ
I
VGV
D
KLAP
A
T
SS
L
-
S
LS
Q
I
I
A
D
----------
N
T
P
L
T
--
TA
I
T
THG
DE
L
A
AV
LFTSGT
E
G
L
PKGV
ML
THNN
ILA
S
E
R
A
Y
CAR
L
N
LT
W
QDV
FM
MPA
P
L
G
H
ATGFLH
G
VT
AP
-----
FL
I
GA
R
S
VL
LDIF
TP
D
AC
LA
L
L
E
Q
Q
R
C
T
C
M
LGA
T
P
F
V
-
Y
D
L
L
N
L
L
E--
K
QP
A
D
L
SA
L
R
F
F
L
C
GG
TT
IP
KKV-
AR
E
C
Q
Q
R
G
I
K
LL
S
VYG
S
TE
SSP
HA
V
VN
---
LDDP
LS
R
----
F
M
HT
D
GY
AA
-
AGV
E
IK
V
V
DD
ARK
T
LP
P
G
C
E
GE
EAS
R
---
GP
NV
F
M
GYF
DE
P
E
L
TA
R
ALD
E
E
GWY
Y
SGDL
CRM
DE
A
GYI
KIT
GR
K
KD
I
I
V
RGGENIS
SR
E
V
E
D
ILL
Q
HPKI
H
DA
C
VV
A
M
P
DE
RL
GE
R
SCAYVVLK
A
P
H
HS
LS
L
EEV
V
A
F
FS
RK
R
V
AK
Y
K
Y
P
EH
I
V
VI
E
K
LPRT
A
SGKI
Q
K
F
L
LR
KDIMR
RLTQDVCEEIE
fig|749537.3.peg.1779
Escherichia coli MS 115-1
MKVTLTFNEQRRAAYR
QQ
G
L
W
G
D
AS
LAD
YW
-
QQ
TA
R
A
MP
D
K
IAVVD
NH
G
AS
Y
T
Y
S
A
L
DH
AA
S
C
LAN
WMLAK
GI
E
S
GD
RI
A
F
QL
P
G
WC
EF
TVI
Y
L
A
C
LKIGA
VS
VP
L
L
P
S
WR
E
A
EL
V
W
V
L
NKC
QA
KMFFAP
T
----
LFK
Q
T
R
P
VD
LI
LPL
Q
NQ
L
P
QL
QQ
I
VGV
D
KLAP
A
T
SS
L
-
S
LS
Q
I
I
A
D
----------
N
T
P
L
T
--
TA
I
T
THG
DE
L
A
AV
LFTSGT
E
G
L
PKGV
ML
THNN
ILA
S
E
R
A
Y
CAR
L
N
LT
W
QDV
FM
MPA
P
L
G
H
ATGFLH
G
VT
AP
-----
FL
I
GA
R
S
VL
LDIF
TP
D
AC
LA
L
L
E
Q
Q
R
C
T
C
M
LGA
T
P
F
V
-
Y
D
L
L
N
L
L
E--
K
QP
A
D
L
SA
L
R
F
F
L
C
GG
TT
IP
KKV-
AR
E
C
Q
Q
R
G
I
K
LL
S
VYG
S
TE
SSP
HA
V
VN
---
LDDP
LS
R
----
F
M
HT
D
GY
AA
-
AGV
E
IK
V
V
DD
ARK
T
LP
P
G
C
E
GE
EAS
R
---
GP
NV
F
M
GYF
DE
P
E
L
TA
R
ALD
E
E
GWY
Y
SGDL
CRM
DE
A
GYI
KIT
GR
K
KD
I
I
V
RGGENIS
SR
E
V
E
D
ILL
Q
HPKI
H
DA
C
VV
A
M
P
DE
RL
GE
R
SCAYVVLK
A
P
H
HS
LS
L
EEV
V
A
F
FS
RK
R
V
AK
Y
K
Y
P
EH
I
V
VI
E
K
LPRT
A
SGKI
Q
K
F
L
LR
KDIMR
RLTQDVCEEIE
fig|550672.3.peg.2545
Escherichia coli B088 (19-566/566)
MKVTLTFNEQRRAAYR
QQ
G
L
W
G
D
AS
LAD
YW
-
QQ
TA
R
A
MP
D
K
IAVVD
NH
G
AS
Y
T
Y
S
A
L
DH
AA
S
C
LAN
WMLAK
GI
E
S
GD
RI
A
F
QL
P
G
WC
EF
TVI
Y
L
A
C
LKIGA
VS
VP
L
L
P
S
WR
E
A
EL
V
W
V
L
NKC
QA
KMFFAP
T
----
LFK
Q
T
R
P
VD
LI
LPL
Q
NQ
L
P
QL
QQ
I
VGV
D
KLAP
A
T
SS
L
-
S
LS
Q
I
I
A
D
----------
N
T
P
L
T
--
TA
I
T
THG
DE
L
A
AV
LFTSGT
E
G
L
PKGV
ML
THNN
ILA
S
E
R
A
Y
CAR
L
N
LT
W
QDV
FM
MPA
P
L
G
H
ATGFLH
G
VT
AP
-----
FL
I
GA
R
S
VL
LDIF
TP
D
AC
LA
L
L
E
Q
Q
R
C
T
C
M
LGA
T
P
F
V
-
Y
D
L
L
N
L
L
E--
K
QP
A
D
L
SA
L
R
F
F
L
C
GG
TT
IP
KKV-
AR
E
C
Q
Q
R
G
I
K
LL
S
VYG
S
TE
SSP
HA
V
VN
---
LDDP
LS
R
----
F
M
HT
D
GY
AA
-
AGV
E
IK
V
V
DD
ARK
T
LP
P
G
C
E
GE
EAS
R
---
GP
NV
F
M
GYF
DE
P
E
L
TA
R
ALD
E
E
GWY
Y
SGDL
CRM
DE
A
GYI
KIT
GR
K
KD
I
I
V
RGGENIS
SR
E
V
E
D
ILL
Q
HPKI
H
DA
C
VV
A
M
P
DE
RL
GE
R
SCAYVVLK
A
P
H
HS
LS
L
EEV
V
A
F
FS
RK
R
V
AK
Y
K
Y
P
EH
I
V
VI
E
K
LPRT
A
SGKI
Q
K
F
L
LR
KDIMR
RLTQDVCEEIE
fig|670888.3.peg.204
Escherichia coli 1827-70
MKVTLTFNEQRRAAYR
QQ
G
L
W
G
D
AS
LAD
YW
-
QQ
TA
R
A
MP
D
K
IAVVD
NH
G
AS
Y
T
Y
S
A
L
DH
AA
S
C
LAN
WMLAK
GI
E
S
GD
RI
A
F
QL
P
G
WC
EF
TVI
Y
L
A
C
LKIGA
VS
VP
L
L
P
S
WR
E
A
EL
V
W
V
L
NKC
QA
KMFFAP
T
----
LFK
Q
T
R
P
VD
LI
LPL
Q
NQ
L
P
QL
QQ
I
VGV
D
KLAP
A
T
SS
L
-
S
LS
Q
I
I
A
D
----------
N
T
P
L
T
--
TA
I
T
THG
DE
L
A
AV
LFTSGT
E
G
L
PKGV
ML
THNN
ILA
S
E
R
A
Y
CAR
L
N
LT
W
QDV
FM
MPA
P
L
G
H
ATGFLH
G
VT
AP
-----
FL
I
GA
R
S
VL
LDIF
TP
D
AC
LA
L
L
E
Q
Q
R
C
T
C
M
LGA
T
P
F
V
-
Y
D
L
L
N
V
L
E--
K
QP
A
D
L
SA
L
R
F
F
L
C
GG
TT
IP
KKV-
AR
E
C
Q
Q
R
G
I
K
LL
S
VYG
S
TE
SSP
HA
V
VN
---
LDDP
LS
R
----
F
M
HT
D
GY
AA
-
AGV
E
IK
V
V
DD
ARK
T
LP
P
G
C
E
GE
EAS
R
---
GP
NV
F
M
GYF
DE
P
E
L
TA
R
ALD
E
E
GWY
Y
SGDL
CRM
DE
A
GYI
KIT
GR
K
KD
I
I
V
RGGENIS
SR
E
V
E
D
ILL
Q
HPKI
H
DA
C
VV
A
M
P
DE
RL
GE
R
SCAYVVLK
A
P
H
HS
LS
L
EEV
V
A
F
FS
RK
R
V
AK
Y
K
Y
P
EH
I
V
VI
E
K
LPRT
A
SGKI
Q
K
F
L
LR
KDIMR
RLTQDVCEEIE
fig|155864.1.peg.2443
Escherichia coli O157:H7 EDL933 (19-566/566)
MKVTLTFNEQRRAAYR
QQ
G
L
W
G
D
AS
LAD
YW
-
QQ
TA
R
A
MP
D
K
IAVVD
NH
G
AS
Y
T
Y
S
A
L
DH
AA
S
C
LAN
WMLAK
GI
E
S
GD
RI
A
F
QL
P
G
WC
EF
TVI
Y
L
A
C
LKIGA
VS
VP
L
L
P
S
WR
E
A
EL
V
W
V
L
NKC
QA
KMFFTP
T
----
LFK
Q
T
R
P
VD
LI
LPL
Q
NQ
L
P
QL
QQ
I
VGV
D
KLAP
A
T
SS
L
-
S
LS
Q
I
I
A
D
----------
N
T
P
L
T
--
TA
I
T
THG
DE
L
A
AV
LFTSGT
E
G
L
PKGV
ML
THNN
ILA
S
E
R
A
Y
CAR
L
N
LT
W
QDV
FM
MPA
P
L
G
H
ATGFLH
G
VT
AP
-----
FL
I
GA
R
S
VL
LDIF
TP
D
AC
LA
L
L
E
Q
Q
R
C
S
C
M
LGA
T
P
F
V
-
Y
D
L
L
N
L
L
E--
K
QP
A
D
L
SA
L
R
F
F
L
C
GG
TT
IP
KKV-
AR
E
C
Q
Q
R
G
I
K
LL
S
VYG
S
TE
SSP
HA
V
VN
---
LDDP
LS
R
----
F
M
HT
D
GY
AA
-
AGV
E
IK
V
V
DD
ARK
T
LP
P
G
C
E
GE
EAS
R
---
GP
NV
F
M
GYF
DE
P
E
L
TA
R
ALD
E
E
GWY
Y
SGDL
CRM
DE
A
GYI
KIT
GR
K
KD
I
I
V
RGGENIS
SR
E
V
E
D
ILL
Q
HPKI
H
DA
C
VV
A
M
P
DE
RL
GE
R
SCAYVVLK
A
P
H
HS
LS
L
EEV
V
A
F
FS
RK
R
V
AK
Y
K
Y
P
EH
I
V
VI
E
K
LPRT
A
SGKI
Q
K
F
L
LR
KDIMR
RLTQDVCEEIE
fig|562.371.peg.4555
Escherichia coli 1044A
MKVTLTFNEQRRAAYR
QQ
G
L
W
G
D
AS
LAD
YW
-
QQ
TA
R
A
MP
D
K
IAVVD
NH
G
AS
Y
T
Y
S
A
L
DH
AA
S
C
LAN
WMLAK
GI
E
S
GD
RI
A
F
QL
P
G
WC
EF
TVI
Y
L
A
C
LKIGA
VS
VP
L
L
P
S
WR
E
A
EL
V
W
V
L
NKC
QA
KMFFTP
T
----
LFK
Q
T
R
P
VD
LI
LPL
Q
NQ
L
P
QL
QQ
I
VGV
D
KLAP
A
T
SS
L
-
S
LS
Q
I
I
A
D
----------
N
T
P
L
T
--
TA
I
T
THG
DE
L
A
AV
LFTSGT
E
G
L
PKGV
ML
THNN
ILA
S
E
R
A
Y
CAR
L
N
LT
W
QDV
FM
MPA
P
L
G
H
ATGFLH
G
VT
AP
-----
FL
I
GA
R
S
VL
LDIF
TP
D
AC
LA
L
L
E
Q
Q
R
C
S
C
M
LGA
T
P
F
V
-
Y
D
L
L
N
L
L
E--
K
QP
A
D
L
SA
L
R
F
F
L
C
GG
TT
IP
KKV-
AR
E
C
Q
Q
R
G
I
K
LL
S
VYG
S
TE
SSP
HA
V
VN
---
LDDP
LS
R
----
F
M
HT
D
GY
AA
-
AGV
E
IK
V
V
DD
ARK
T
LP
P
G
C
E
GE
EAS
R
---
GP
NV
F
M
GYF
DE
P
E
L
TA
R
ALD
E
E
GWY
Y
SGDL
CRM
DE
A
GYI
KIT
GR
K
KD
I
I
V
RGGENIS
SR
E
V
E
D
ILL
Q
HPKI
H
DA
C
VV
A
M
P
DE
RL
GE
R
SCAYVVLK
A
P
H
HS
LS
L
EEV
V
A
F
FS
RK
R
V
AK
Y
K
Y
P
EH
I
V
VI
E
K
LPRT
A
SGKI
Q
K
F
L
LR
KDIMR
RLTQDVCEEIE
fig|562.372.peg.4788
Escherichia coli 1212A
MKVTLTFNEQRRAAYR
QQ
G
L
W
G
D
AS
LAD
YW
-
QQ
TA
R
A
MP
D
K
IAVVD
NH
G
AS
Y
T
Y
S
A
L
DH
AA
S
C
LAN
WMLAK
GI
E
S
GD
RI
A
F
QL
P
G
WC
EF
TVI
Y
L
A
C
LKIGA
VS
VP
L
L
P
S
WR
E
A
EL
V
W
V
L
NKC
QA
KMFFTP
T
----
LFK
Q
T
R
P
VD
LI
LPL
Q
NQ
L
P
QL
QQ
I
VGV
D
KLAP
A
T
SS
L
-
S
LS
Q
I
I
A
D
----------
N
T
P
L
T
--
TA
I
T
THG
DE
L
A
AV
LFTSGT
E
G
L
PKGV
ML
THNN
ILA
S
E
R
A
Y
CAR
L
N
LT
W
QDV
FM
MPA
P
L
G
H
ATGFLH
G
VT
AP
-----
FL
I
GA
R
S
VL
LDIF
TP
D
AC
LA
L
L
E
Q
Q
R
C
S
C
M
LGA
T
P
F
V
-
Y
D
L
L
N
L
L
E--
K
QP
A
D
L
SA
L
R
F
F
L
C
GG
TT
IP
KKV-
AR
E
C
Q
Q
R
G
I
K
LL
S
VYG
S
TE
SSP
HA
V
VN
---
LDDP
LS
R
----
F
M
HT
D
GY
AA
-
AGV
E
IK
V
V
DD
ARK
T
LP
P
G
C
E
GE
EAS
R
---
GP
NV
F
M
GYF
DE
P
E
L
TA
R
ALD
E
E
GWY
Y
SGDL
CRM
DE
A
GYI
KIT
GR
K
KD
I
I
V
RGGENIS
SR
E
V
E
D
ILL
Q
HPKI
H
DA
C
VV
A
M
P
DE
RL
GE
R
SCAYVVLK
A
P
H
HS
LS
L
EEV
V
A
F
FS
RK
R
V
AK
Y
K
Y
P
EH
I
V
VI
E
K
LPRT
A
SGKI
Q
K
F
L
LR
KDIMR
RLTQDVCEEIE
fig|562.374.peg.4324
Escherichia coli 536A
MKVTLTFNEQRRAAYR
QQ
G
L
W
G
D
AS
LAD
YW
-
QQ
TA
R
A
MP
D
K
IAVVD
NH
G
AS
Y
T
Y
S
A
L
DH
AA
S
C
LAN
WMLAK
GI
E
S
GD
RI
A
F
QL
P
G
WC
EF
TVI
Y
L
A
C
LKIGA
VS
VP
L
L
P
S
WR
E
A
EL
V
W
V
L
NKC
QA
KMFFTP
T
----
LFK
Q
T
R
P
VD
LI
LPL
Q
NQ
L
P
QL
QQ
I
VGV
D
KLAP
A
T
SS
L
-
S
LS
Q
I
I
A
D
----------
N
T
P
L
T
--
TA
I
T
THG
DE
L
A
AV
LFTSGT
E
G
L
PKGV
ML
THNN
ILA
S
E
R
A
Y
CAR
L
N
LT
W
QDV
FM
MPA
P
L
G
H
ATGFLH
G
VT
AP
-----
FL
I
GA
R
S
VL
LDIF
TP
D
AC
LA
L
L
E
Q
Q
R
C
S
C
M
LGA
T
P
F
V
-
Y
D
L
L
N
L
L
E--
K
QP
A
D
L
SA
L
R
F
F
L
C
GG
TT
IP
KKV-
AR
E
C
Q
Q
R
G
I
K
LL
S
VYG
S
TE
SSP
HA
V
VN
---
LDDP
LS
R
----
F
M
HT
D
GY
AA
-
AGV
E
IK
V
V
DD
ARK
T
LP
P
G
C
E
GE
EAS
R
---
GP
NV
F
M
GYF
DE
P
E
L
TA
R
ALD
E
E
GWY
Y
SGDL
CRM
DE
A
GYI
KIT
GR
K
KD
I
I
V
RGGENIS
SR
E
V
E
D
ILL
Q
HPKI
H
DA
C
VV
A
M
P
DE
RL
GE
R
SCAYVVLK
A
P
H
HS
LS
L
EEV
V
A
F
FS
RK
R
V
AK
Y
K
Y
P
EH
I
V
VI
E
K
LPRT
A
SGKI
Q
K
F
L
LR
KDIMR
RLTQDVCEEIE
fig|83334.1.peg.2434
Escherichia coli O157:H7
MKVTLTFNEQRRAAYR
QQ
G
L
W
G
D
AS
LAD
YW
-
QQ
TA
R
A
MP
D
K
IAVVD
NH
G
AS
Y
T
Y
S
A
L
DH
AA
S
C
LAN
WMLAK
GI
E
S
GD
RI
A
F
QL
P
G
WC
EF
TVI
Y
L
A
C
LKIGA
VS
VP
L
L
P
S
WR
E
A
EL
V
W
V
L
NKC
QA
KMFFTP
T
----
LFK
Q
T
R
P
VD
LI
LPL
Q
NQ
L
P
QL
QQ
I
VGV
D
KLAP
A
T
SS
L
-
S
LS
Q
I
I
A
D
----------
N
T
P
L
T
--
TA
I
T
THG
DE
L
A
AV
LFTSGT
E
G
L
PKGV
ML
THNN
ILA
S
E
R
A
Y
CAR
L
N
LT
W
QDV
FM
MPA
P
L
G
H
ATGFLH
G
VT
AP
-----
FL
I
GA
R
S
VL
LDIF
TP
D
AC
LA
L
L
E
Q
Q
R
C
S
C
M
LGA
T
P
F
V
-
Y
D
L
L
N
L
L
E--
K
QP
A
D
L
SA
L
R
F
F
L
C
GG
TT
IP
KKV-
AR
E
C
Q
Q
R
G
I
K
LL
S
VYG
S
TE
SSP
HA
V
VN
---
LDDP
LS
R
----
F
M
HT
D
GY
AA
-
AGV
E
IK
V
V
DD
ARK
T
LP
P
G
C
E
GE
EAS
R
---
GP
NV
F
M
GYF
DE
P
E
L
TA
R
ALD
E
E
GWY
Y
SGDL
CRM
DE
A
GYI
KIT
GR
K
KD
I
I
V
RGGENIS
SR
E
V
E
D
ILL
Q
HPKI
H
DA
C
VV
A
M
P
DE
RL
GE
R
SCAYVVLK
A
P
H
HS
LS
L
EEV
V
A
F
FS
RK
R
V
AK
Y
K
Y
P
EH
I
V
VI
E
K
LPRT
A
SGKI
Q
K
F
L
LR
KDIMR
RLTQDVCEEIE
fig|155864.8.peg.2291
Escherichia coli O157:H7 EDL933
MKVTLTFNEQRRAAYR
QQ
G
L
W
G
D
AS
LAD
YW
-
QQ
TA
R
A
MP
D
K
IAVVD
NH
G
AS
Y
T
Y
S
A
L
DH
AA
S
C
LAN
WMLAK
GI
E
S
GD
RI
A
F
QL
P
G
WC
EF
TVI
Y
L
A
C
LKIGA
VS
VP
L
L
P
S
WR
E
A
EL
V
W
V
L
NKC
QA
KMFFTP
T
----
LFK
Q
T
R
P
VD
LI
LPL
Q
NQ
L
P
QL
QQ
I
VGV
D
KLAP
A
T
SS
L
-
S
LS
Q
I
I
A
D
----------
N
T
P
L
T
--
TA
I
T
THG
DE
L
A
AV
LFTSGT
E
G
L
PKGV
ML
THNN
ILA
S
E
R
A
Y
CAR
L
N
LT
W
QDV
FM
MPA
P
L
G
H
ATGFLH
G
VT
AP
-----
FL
I
GA
R
S
VL
LDIF
TP
D
AC
LA
L
L
E
Q
Q
R
C
S
C
M
LGA
T
P
F
V
-
Y
D
L
L
N
L
L
E--
K
QP
A
D
L
SA
L
R
F
F
L
C
GG
TT
IP
KKV-
AR
E
C
Q
Q
R
G
I
K
LL
S
VYG
S
TE
SSP
HA
V
VN
---
LDDP
LS
R
----
F
M
HT
D
GY
AA
-
AGV
E
IK
V
V
DD
ARK
T
LP
P
G
C
E
GE
EAS
R
---
GP
NV
F
M
GYF
DE
P
E
L
TA
R
ALD
E
E
GWY
Y
SGDL
CRM
DE
A
GYI
KIT
GR
K
KD
I
I
V
RGGENIS
SR
E
V
E
D
ILL
Q
HPKI
H
DA
C
VV
A
M
P
DE
RL
GE
R
SCAYVVLK
A
P
H
HS
LS
L
EEV
V
A
F
FS
RK
R
V
AK
Y
K
Y
P
EH
I
V
VI
E
K
LPRT
A
SGKI
Q
K
F
L
LR
KDIMR
RLTQDVCEEIE
fig|478006.5.peg.2690
Escherichia coli O157:H7 str. EC4501
MKVTLTFNEQRRAAYR
QQ
G
L
W
G
D
AS
LAD
YW
-
QQ
TA
R
A
MP
D
K
IAVVD
NH
G
AS
Y
T
Y
S
A
L
DH
AA
S
C
LAN
WMLAK
GI
E
S
GD
RI
A
F
QL
P
G
WC
EF
TVI
Y
L
A
C
LKIGA
VS
VP
L
L
P
S
WR
E
A
EL
V
W
V
L
NKC
QA
KMFFTP
T
----
LFK
Q
T
R
P
VD
LI
LPL
Q
NQ
L
P
QL
QQ
I
VGV
D
KLAP
A
T
SS
L
-
S
LS
Q
I
I
A
D
----------
N
T
P
L
T
--
TA
I
T
THG
DE
L
A
AV
LFTSGT
E
G
L
PKGV
ML
THNN
ILA
S
E
R
A
Y
CAR
L
N
LT
W
QDV
FM
MPA
P
L
G
H
ATGFLH
G
VT
AP
-----
FL
I
GA
R
S
VL
LDIF
TP
D
AC
LA
L
L
E
Q
Q
R
C
S
C
M
LGA
T
P
F
V
-
Y
D
L
L
N
L
L
E--
K
QP
A
D
L
SA
L
R
F
F
L
C
GG
TT
IP
KKV-
AR
E
C
Q
Q
R
G
I
K
LL
S
VYG
S
TE
SSP
HA
V
VN
---
LDDP
LS
R
----
F
M
HT
D
GY
AA
-
AGV
E
IK
V
V
DD
ARK
T
LP
P
G
C
E
GE
EAS
R
---
GP
NV
F
M
GYF
DE
P
E
L
TA
R
ALD
E
E
GWY
Y
SGDL
CRM
DE
A
GYI
KIT
GR
K
KD
I
I
V
RGGENIS
SR
E
V
E
D
ILL
Q
HPKI
H
DA
C
VV
A
M
P
DE
RL
GE
R
SCAYVVLK
A
P
H
HS
LS
L
EEV
V
A
F
FS
RK
R
V
AK
Y
K
Y
P
EH
I
V
VI
E
K
LPRT
A
SGKI
Q
K
F
L
LR
KDIMR
RLTQDVCEEIE
fig|478008.5.peg.4877
Escherichia coli O157:H7 str. EC869
MKVTLTFNEQRRAAYR
QQ
G
L
W
G
D
AS
LAD
YW
-
QQ
TA
R
A
MP
D
K
IAVVD
NH
G
AS
Y
T
Y
S
A
L
DH
AA
S
C
LAN
WMLAK
GI
E
S
GD
RI
A
F
QL
P
G
WC
EF
TVI
Y
L
A
C
LKIGA
VS
VP
L
L
P
S
WR
E
A
EL
V
W
V
L
NKC
QA
KMFFTP
T
----
LFK
Q
T
R
P
VD
LI
LPL
Q
NQ
L
P
QL
QQ
I
VGV
D
KLAP
A
T
SS
L
-
S
LS
Q
I
I
A
D
----------
N
T
P
L
T
--
TA
I
T
THG
DE
L
A
AV
LFTSGT
E
G
L
PKGV
ML
THNN
ILA
S
E
R
A
Y
CAR
L
N
LT
W
QDV
FM
MPA
P
L
G
H
ATGFLH
G
VT
AP
-----
FL
I
GA
R
S
VL
LDIF
TP
D
AC
LA
L
L
E
Q
Q
R
C
S
C
M
LGA
T
P
F
V
-
Y
D
L
L
N
L
L
E--
K
QP
A
D
L
SA
L
R
F
F
L
C
GG
TT
IP
KKV-
AR
E
C
Q
Q
R
G
I
K
LL
S
VYG
S
TE
SSP
HA
V
VN
---
LDDP
LS
R
----
F
M
HT
D
GY
AA
-
AGV
E
IK
V
V
DD
ARK
T
LP
P
G
C
E
GE
EAS
R
---
GP
NV
F
M
GYF
DE
P
E
L
TA
R
ALD
E
E
GWY
Y
SGDL
CRM
DE
A
GYI
KIT
GR
K
KD
I
I
V
RGGENIS
SR
E
V
E
D
ILL
Q
HPKI
H
DA
C
VV
A
M
P
DE
RL
GE
R
SCAYVVLK
A
P
H
HS
LS
L
EEV
V
A
F
FS
RK
R
V
AK
Y
K
Y
P
EH
I
V
VI
E
K
LPRT
A
SGKI
Q
K
F
L
LR
KDIMR
RLTQDVCEEIE
fig|637388.3.peg.4937
Escherichia coli O157:H7 str. FRIK2000
MKVTLTFNEQRRAAYR
QQ
G
L
W
G
D
AS
LAD
YW
-
QQ
TA
R
A
MP
D
K
IAVVD
NH
G
AS
Y
T
Y
S
A
L
DH
AA
S
C
LAN
WMLAK
GI
E
S
GD
RI
A
F
QL
P
G
WC
EF
TVI
Y
L
A
C
LKIGA
VS
VP
L
L
P
S
WR
E
A
EL
V
W
V
L
NKC
QA
KMFFTP
T
----
LFK
Q
T
R
P
VD
LI
LPL
Q
NQ
L
P
QL
QQ
I
VGV
D
KLAP
A
T
SS
L
-
S
LS
Q
I
I
A
D
----------
N
T
P
L
T
--
TA
I
T
THG
DE
L
A
AV
LFTSGT
E
G
L
PKGV
ML
THNN
ILA
S
E
R
A
Y
CAR
L
N
LT
W
QDV
FM
MPA
P
L
G
H
ATGFLH
G
VT
AP
-----
FL
I
GA
R
S
VL
LDIF
TP
D
AC
LA
L
L
E
Q
Q
R
C
S
C
M
LGA
T
P
F
V
-
Y
D
L
L
N
L
L
E--
K
QP
A
D
L
SA
L
R
F
F
L
C
GG
TT
IP
KKV-
AR
E
C
Q
Q
R
G
I
K
LL
S
VYG
S
TE
SSP
HA
V
VN
---
LDDP
LS
R
----
F
M
HT
D
GY
AA
-
AGV
E
IK
V
V
DD
ARK
T
LP
P
G
C
E
GE
EAS
R
---
GP
NV
F
M
GYF
DE
P
E
L
TA
R
ALD
E
E
GWY
Y
SGDL
CRM
DE
A
GYI
KIT
GR
K
KD
I
I
V
RGGENIS
SR
E
V
E
D
ILL
Q
HPKI
H
DA
C
VV
A
M
P
DE
RL
GE
R
SCAYVVLK
A
P
H
HS
LS
L
EEV
V
A
F
FS
RK
R
V
AK
Y
K
Y
P
EH
I
V
VI
E
K
LPRT
A
SGKI
Q
K
F
L
LR
KDIMR
RLTQDVCEEIE
fig|570506.3.peg.4295
Escherichia coli O157:H7 str. FRIK966
MKVTLTFNEQRRAAYR
QQ
G
L
W
G
D
AS
LAD
YW
-
QQ
TA
R
A
MP
D
K
IAVVD
NH
G
AS
Y
T
Y
S
A
L
DH
AA
S
C
LAN
WMLAK
GI
E
S
GD
RI
A
F
QL
P
G
WC
EF
TVI
Y
L
A
C
LKIGA
VS
VP
L
L
P
S
WR
E
A
EL
V
W
V
L
NKC
QA
KMFFTP
T
----
LFK
Q
T
R
P
VD
LI
LPL
Q
NQ
L
P
QL
QQ
I
VGV
D
KLAP
A
T
SS
L
-
S
LS
Q
I
I
A
D
----------
N
T
P
L
T
--
TA
I
T
THG
DE
L
A
AV
LFTSGT
E
G
L
PKGV
ML
THNN
ILA
S
E
R
A
Y
CAR
L
N
LT
W
QDV
FM
MPA
P
L
G
H
ATGFLH
G
VT
AP
-----
FL
I
GA
R
S
VL
LDIF
TP
D
AC
LA
L
L
E
Q
Q
R
C
S
C
M
LGA
T
P
F
V
-
Y
D
L
L
N
L
L
E--
K
QP
A
D
L
SA
L
R
F
F
L
C
GG
TT
IP
KKV-
AR
E
C
Q
Q
R
G
I
K
LL
S
VYG
S
TE
SSP
HA
V
VN
---
LDDP
LS
R
----
F
M
HT
D
GY
AA
-
AGV
E
IK
V
V
DD
ARK
T
LP
P
G
C
E
GE
EAS
R
---
GP
NV
F
M
GYF
DE
P
E
L
TA
R
ALD
E
E
GWY
Y
SGDL
CRM
DE
A
GYI
KIT
GR
K
KD
I
I
V
RGGENIS
SR
E
V
E
D
ILL
Q
HPKI
H
DA
C
VV
A
M
P
DE
RL
GE
R
SCAYVVLK
A
P
H
HS
LS
L
EEV
V
A
F
FS
RK
R
V
AK
Y
K
Y
P
EH
I
V
VI
E
K
LPRT
A
SGKI
Q
K
F
L
LR
KDIMR
RLTQDVCEEIE
fig|386585.9.peg.2522
Escherichia coli O157:H7 str. Sakai
MKVTLTFNEQRRAAYR
QQ
G
L
W
G
D
AS
LAD
YW
-
QQ
TA
R
A
MP
D
K
IAVVD
NH
G
AS
Y
T
Y
S
A
L
DH
AA
S
C
LAN
WMLAK
GI
E
S
GD
RI
A
F
QL
P
G
WC
EF
TVI
Y
L
A
C
LKIGA
VS
VP
L
L
P
S
WR
E
A
EL
V
W
V
L
NKC
QA
KMFFTP
T
----
LFK
Q
T
R
P
VD
LI
LPL
Q
NQ
L
P
QL
QQ
I
VGV
D
KLAP
A
T
SS
L
-
S
LS
Q
I
I
A
D
----------
N
T
P
L
T
--
TA
I
T
THG
DE
L
A
AV
LFTSGT
E
G
L
PKGV
ML
THNN
ILA
S
E
R
A
Y
CAR
L
N
LT
W
QDV
FM
MPA
P
L
G
H
ATGFLH
G
VT
AP
-----
FL
I
GA
R
S
VL
LDIF
TP
D
AC
LA
L
L
E
Q
Q
R
C
S
C
M
LGA
T
P
F
V
-
Y
D
L
L
N
L
L
E--
K
QP
A
D
L
SA
L
R
F
F
L
C
GG
TT
IP
KKV-
AR
E
C
Q
Q
R
G
I
K
LL
S
VYG
S
TE
SSP
HA
V
VN
---
LDDP
LS
R
----
F
M
HT
D
GY
AA
-
AGV
E
IK
V
V
DD
ARK
T
LP
P
G
C
E
GE
EAS
R
---
GP
NV
F
M
GYF
DE
P
E
L
TA
R
ALD
E
E
GWY
Y
SGDL
CRM
DE
A
GYI
KIT
GR
K
KD
I
I
V
RGGENIS
SR
E
V
E
D
ILL
Q
HPKI
H
DA
C
VV
A
M
P
DE
RL
GE
R
SCAYVVLK
A
P
H
HS
LS
L
EEV
V
A
F
FS
RK
R
V
AK
Y
K
Y
P
EH
I
V
VI
E
K
LPRT
A
SGKI
Q
K
F
L
LR
KDIMR
RLTQDVCEEIE
fig|502346.5.peg.4993
Escherichia coli O157:H7 str. TW14588
MKVTLTFNEQRRAAYR
QQ
G
L
W
G
D
AS
LAD
YW
-
QQ
TA
R
A
MP
D
K
IAVVD
NH
G
AS
Y
T
Y
S
A
L
DH
AA
S
C
LAN
WMLAK
GI
E
S
GD
RI
A
F
QL
P
G
WC
EF
TVI
Y
L
A
C
LKIGA
VS
VP
L
L
P
S
WR
E
A
EL
V
W
V
L
NKC
QA
KMFFTP
T
----
LFK
Q
T
R
P
VD
LI
LPL
Q
NQ
L
P
QL
QQ
I
VGV
D
KLAP
A
T
SS
L
-
S
LS
Q
I
I
A
D
----------
N
T
P
L
T
--
TA
I
T
THG
DE
L
A
AV
LFTSGT
E
G
L
PKGV
ML
THNN
ILA
S
E
R
A
Y
CAR
L
N
LT
W
QDV
FM
MPA
P
L
G
H
ATGFLH
G
VT
AP
-----
FL
I
GA
R
S
VL
LDIF
TP
D
AC
LA
L
L
E
Q
Q
R
C
S
C
M
LGA
T
P
F
V
-
Y
D
L
L
N
L
L
E--
K
QP
A
D
L
SA
L
R
F
F
L
C
GG
TT
IP
KKV-
AR
E
C
Q
Q
R
G
I
K
LL
S
VYG
S
TE
SSP
HA
V
VN
---
LDDP
LS
R
----
F
M
HT
D
GY
AA
-
AGV
E
IK
V
V
DD
ARK
T
LP
P
G
C
E
GE
EAS
R
---
GP
NV
F
M
GYF
DE
P
E
L
TA
R
ALD
E
E
GWY
Y
SGDL
CRM
DE
A
GYI
KIT
GR
K
KD
I
I
V
RGGENIS
SR
E
V
E
D
ILL
Q
HPKI
H
DA
C
VV
A
M
P
DE
RL
GE
R
SCAYVVLK
A
P
H
HS
LS
L
EEV
V
A
F
FS
RK
R
V
AK
Y
K
Y
P
EH
I
V
VI
E
K
LPRT
A
SGKI
Q
K
F
L
LR
KDIMR
RLTQDVCEEIE
fig|701177.3.peg.2097
Escherichia coli O55:H7 str. CB9615
MKVTLTFNEQRRAAYR
QQ
G
L
W
G
D
AS
LAD
YW
-
QQ
TA
R
A
MP
D
K
IAVVD
NH
G
AS
Y
T
Y
S
A
L
DH
AA
S
C
LAN
WMLAK
GI
E
S
GD
RI
A
F
QL
P
G
WC
EF
TVI
Y
L
A
C
LKIGA
VS
VP
L
L
P
S
WR
E
A
EL
V
W
V
L
NKC
QA
KMFFTP
T
----
LFK
Q
T
R
P
VD
LI
LPL
Q
NQ
L
P
QL
QQ
I
VGV
D
KLAP
A
T
SS
L
-
S
LS
Q
I
I
A
D
----------
N
T
P
L
T
--
TA
I
T
THG
DE
L
A
AV
LFTSGT
E
G
L
PKGV
ML
THNN
ILA
S
E
R
A
Y
CAR
L
N
LT
W
QDV
FM
MPA
P
L
G
H
ATGFLH
G
VT
AP
-----
FL
I
GA
R
S
VL
LDIF
TP
D
AC
LA
L
L
E
Q
Q
R
C
S
C
M
LGA
T
P
F
V
-
Y
D
L
L
N
L
L
E--
K
QP
A
D
L
SA
L
R
F
F
L
C
GG
TT
IP
KKV-
AR
E
C
Q
Q
R
G
I
K
LL
S
VYG
S
TE
SSP
HA
V
VN
---
LDDP
LS
R
----
F
M
HT
D
GY
AA
-
AGV
E
IK
V
V
DD
ARK
T
LP
P
G
C
E
GE
EAS
R
---
GP
NV
F
M
GYF
DE
P
E
L
TA
R
ALD
E
E
GWY
Y
SGDL
CRM
DE
A
GYI
KIT
GR
K
KD
I
I
V
RGGENIS
SR
E
V
E
D
ILL
Q
HPKI
H
DA
C
VV
A
M
P
DE
RL
GE
R
SCAYVVLK
A
P
H
HS
LS
L
EEV
V
A
F
FS
RK
R
V
AK
Y
K
Y
P
EH
I
V
VI
E
K
LPRT
A
SGKI
Q
K
F
L
LR
KDIMR
RLTQDVCEEIE
fig|656419.3.peg.2415
Escherichia coli M718
MKVTLTFNEQRRAAYR
QQ
G
L
W
G
D
AS
LAD
YW
-
QQ
TA
R
A
MP
D
K
IAVVD
NH
G
AS
Y
T
Y
S
A
L
DH
AA
S
C
LAN
WMLAK
GI
E
S
G
A
RI
A
F
QL
P
G
WC
EF
TVI
Y
L
A
C
LKIGA
VS
VP
L
L
P
S
WR
E
A
EL
V
W
V
L
NKC
QA
KMFFAP
T
----
LFK
Q
T
R
P
VD
LI
LPL
Q
NQ
L
P
QL
QQ
I
VGV
D
KLAP
A
T
SS
L
-
S
LS
Q
I
I
A
D
----------
N
T
P
L
T
--
TA
I
T
THG
DE
L
A
AV
LFTSGT
E
G
L
PKGV
ML
THNN
ILA
S
E
R
A
Y
CAR
L
N
LT
W
QDV
FM
MPA
P
L
G
H
ATGFLH
G
VT
AP
-----
FL
I
GA
R
S
VL
LDIF
TP
D
AC
LA
L
L
E
Q
Q
R
C
T
C
M
LGA
T
P
F
V
-
Y
D
L
L
N
L
L
E--
K
QP
A
D
L
SA
L
R
F
F
L
C
GG
TT
IP
KKV-
AR
E
C
Q
Q
R
G
I
K
LL
S
VYG
S
TE
SSP
HA
V
VN
---
LDDP
LS
R
----
F
M
HT
D
GY
AA
-
AGV
E
IK
V
V
DD
ARK
T
LP
P
G
C
E
GE
EAS
R
---
GP
NV
F
M
GYF
DE
P
E
L
TA
R
ALD
E
E
GWY
Y
SGDL
CRM
DE
A
GYI
KIT
GR
K
KD
I
I
V
RGGENIS
SR
E
V
E
D
ILL
Q
HPKI
H
DA
C
VV
A
M
P
DE
RL
GE
R
SCAYVVLK
A
P
H
HS
LS
L
EEV
V
A
F
FS
RK
R
V
AK
Y
K
Y
P
EH
I
V
VI
E
K
LPRT
A
SGKI
Q
K
F
L
LR
KDIMR
RLTQD
I
CEEIE
fig|340184.6.peg.3064
Escherichia coli B7A
MKVTLTFNEQRRAAYR
QQ
G
L
W
G
D
AS
LAD
YW
-
QQ
TA
R
A
MP
D
K
IAVVD
NH
G
AS
Y
T
Y
S
A
L
DH
AA
S
C
LAN
WMLAK
GI
E
S
GD
RI
A
F
QL
P
G
WC
EF
TVI
Y
L
A
C
LKIGA
VS
VP
L
L
P
S
WR
E
A
EL
V
W
V
L
NKC
QA
KMFFAP
T
----
LFK
Q
T
R
P
VD
LI
LPL
Q
NQ
L
P
QL
QQ
I
VGV
D
KLAP
A
T
SS
L
-
S
LS
Q
I
I
A
D
----------
N
T
P
L
T
--
TA
I
T
THG
DE
L
A
AV
LFTSGT
E
G
L
PKGV
ML
THNN
ILA
S
E
R
A
Y
CAR
L
N
LT
W
QDV
FM
MPA
P
L
G
H
ATGFLH
G
VT
AP
-----
FL
I
GA
R
S
VL
LDIF
TP
D
AC
LA
L
L
E
Q
Q
R
C
T
C
M
LGA
T
P
F
V
-
Y
D
L
L
N
V
L
E--
K
QP
A
D
L
SA
L
R
F
F
L
C
GG
TT
IP
KKV-
AR
E
C
Q
Q
L
G
I
K
LL
S
VYG
S
TE
SSP
HA
V
VN
---
LDDP
LS
R
----
F
M
HT
D
GY
AA
-
AGV
E
IK
V
V
DD
ARK
T
LP
P
G
C
E
GE
EAS
R
---
GP
NV
F
M
GYF
DE
P
E
L
TA
R
ALD
E
E
GWY
Y
SGDL
CRM
DE
A
GYI
KIT
GR
K
KD
I
I
V
RGGENIS
SR
E
V
E
D
ILL
Q
HPKI
H
DA
C
VV
A
M
P
DE
RL
GE
R
SCAYVVLK
A
P
H
HS
LS
L
EEV
V
A
F
FS
RK
R
V
AK
Y
K
Y
P
EH
I
V
VI
E
K
LPRT
A
SGKI
Q
K
F
L
LR
KDIMR
RLTQDVCEEIE
fig|340186.5.peg.2253
Escherichia coli E110019
MKVTLTFNEQRRAAYR
QQ
G
L
W
G
D
AS
LAD
YW
-
QQ
TA
R
A
MP
D
K
IAVVD
NH
G
AS
Y
T
Y
S
A
L
DH
AA
S
C
LAN
WMLAK
GI
E
S
GD
RI
A
F
QL
P
G
WC
EF
TVI
Y
L
A
C
LKIGA
VS
VP
L
L
P
S
WR
E
A
EL
V
W
V
L
NKC
QA
KMFFAP
T
----
LFK
Q
T
R
P
VD
LI
LPL
Q
NQ
L
P
QL
QQ
I
VGV
D
KLAP
A
T
SS
L
-
S
LS
Q
I
I
A
D
----------
N
T
P
L
T
--
TA
I
T
THG
DE
L
A
AV
LFTSGT
E
G
L
PKGV
ML
THNN
ILA
S
E
R
A
Y
CAR
L
N
LT
W
QDV
FM
MPA
P
L
G
H
ATGFLH
G
VT
AP
-----
FL
I
GA
R
S
VL
LDIF
TP
D
AC
LA
L
L
E
Q
Q
R
C
T
C
M
LGA
T
P
F
V
-
Y
D
L
L
N
V
L
E--
K
QP
A
D
L
SA
L
R
F
F
L
C
GG
TT
IP
KKV-
AR
E
C
Q
Q
L
G
I
K
LL
S
VYG
S
TE
SSP
HA
V
VN
---
LDDP
LS
R
----
F
M
HT
D
GY
AA
-
AGV
E
IK
V
V
DD
ARK
T
LP
P
G
C
E
GE
EAS
R
---
GP
NV
F
M
GYF
DE
P
E
L
TA
R
ALD
E
E
GWY
Y
SGDL
CRM
DE
A
GYI
KIT
GR
K
KD
I
I
V
RGGENIS
SR
E
V
E
D
ILL
Q
HPKI
H
DA
C
VV
A
M
P
DE
RL
GE
R
SCAYVVLK
A
P
H
HS
LS
L
EEV
V
A
F
FS
RK
R
V
AK
Y
K
Y
P
EH
I
V
VI
E
K
LPRT
A
SGKI
Q
K
F
L
LR
KDIMR
RLTQDVCEEIE
fig|679204.3.peg.627
Escherichia coli MS 145-7
MKVTLTFNEQRRAAYR
QQ
G
L
W
G
D
AS
LAD
YW
-
QQ
TA
R
A
MP
D
K
IAVVD
NH
G
AS
Y
T
Y
S
A
L
DH
AA
S
C
LAN
WMLAK
GI
E
S
GD
RI
A
F
QL
P
G
WC
EF
TVI
Y
L
A
C
LKIGA
VS
VP
L
L
P
S
WR
E
A
EL
V
W
V
L
NKC
QA
KMFFAP
T
----
LFK
Q
T
R
P
VD
LI
LPL
Q
NQ
L
P
QL
QQ
I
VGV
D
KLAP
A
T
SS
L
-
S
LS
Q
I
I
A
D
----------
N
T
P
L
T
--
TA
I
T
THG
DE
L
A
AV
LFTSGT
E
G
L
PKGV
ML
THNN
ILA
S
E
R
A
Y
CAR
L
N
LT
W
QDV
FM
MPA
P
L
G
H
ATGFLH
G
VT
AP
-----
FL
I
GA
R
S
VL
LDIF
TP
D
AC
LA
L
L
E
Q
Q
R
C
T
C
M
LGA
T
P
F
V
-
Y
D
L
L
N
V
L
E--
K
QP
A
D
L
SA
L
R
F
F
L
C
GG
TT
IP
KKV-
AR
E
C
Q
Q
L
G
I
K
LL
S
VYG
S
TE
SSP
HA
V
VN
---
LDDP
LS
R
----
F
M
HT
D
GY
AA
-
AGV
E
IK
V
V
DD
ARK
T
LP
P
G
C
E
GE
EAS
R
---
GP
NV
F
M
GYF
DE
P
E
L
TA
R
ALD
E
E
GWY
Y
SGDL
CRM
DE
A
GYI
KIT
GR
K
KD
I
I
V
RGGENIS
SR
E
V
E
D
ILL
Q
HPKI
H
DA
C
VV
A
M
P
DE
RL
GE
R
SCAYVVLK
A
P
H
HS
LS
L
EEV
V
A
F
FS
RK
R
V
AK
Y
K
Y
P
EH
I
V
VI
E
K
LPRT
A
SGKI
Q
K
F
L
LR
KDIMR
RLTQDVCEEIE
fig|573235.3.peg.2470
Escherichia coli O26:H11 str. 11368
MKVTLTFNEQRRAAYR
QQ
G
L
W
G
D
AS
LAD
YW
-
QQ
TA
R
A
MP
D
K
IAVVD
NH
G
AS
Y
T
Y
S
A
L
DH
AA
S
C
LAN
WMLAK
GI
E
S
GD
RI
A
F
QL
P
G
WC
EF
TVI
Y
L
A
C
LKIGA
VS
VP
L
L
P
S
WR
E
A
EL
V
W
V
L
NKC
QA
KMFFAP
T
----
LFK
Q
T
R
P
VD
LI
LPL
Q
NQ
L
P
QL
QQ
I
VGV
D
KLAP
A
T
SS
L
-
S
LS
Q
I
I
A
D
----------
N
T
P
L
T
--
TA
I
T
THG
DE
L
A
AV
LFTSGT
E
G
L
PKGV
ML
THNN
ILA
S
E
R
A
Y
CAR
L
N
LT
W
QDV
FM
MPA
P
L
G
H
ATGFLH
G
VT
AP
-----
FL
I
GA
R
S
VL
LDIF
TP
D
AC
LA
L
L
E
Q
Q
R
C
T
C
M
LGA
T
P
F
V
-
Y
D
L
L
N
V
L
E--
K
QP
A
D
L
SA
L
R
F
F
L
C
GG
TT
IP
KKV-
AR
E
C
Q
Q
L
G
I
K
LL
S
VYG
S
TE
SSP
HA
V
VN
---
LDDP
LS
R
----
F
M
HT
D
GY
AA
-
AGV
E
IK
V
V
DD
ARK
T
LP
P
G
C
E
GE
EAS
R
---
GP
NV
F
M
GYF
DE
P
E
L
TA
R
ALD
E
E
GWY
Y
SGDL
CRM
DE
A
GYI
KIT
GR
K
KD
I
I
V
RGGENIS
SR
E
V
E
D
ILL
Q
HPKI
H
DA
C
VV
A
M
P
DE
RL
GE
R
SCAYVVLK
A
P
H
HS
LS
L
EEV
V
A
F
FS
RK
R
V
AK
Y
K
Y
P
EH
I
V
VI
E
K
LPRT
A
SGKI
Q
K
F
L
LR
KDIMR
RLTQDVCEEIE
fig|409438.11.peg.1971
Escherichia coli SE11
MKVTLTFNEQRRAAYR
QQ
G
L
W
G
D
AS
LAD
YW
-
QQ
TA
R
A
MP
D
K
IAVVD
NH
G
AS
Y
T
Y
S
A
L
DH
AA
S
C
LAN
WMLAK
GI
E
S
GD
RI
A
F
QL
P
G
WC
EF
TVI
Y
L
A
C
LKIGA
VS
VP
L
L
P
S
WR
E
A
EL
V
W
V
L
NKC
QA
KMFFAP
T
----
LFK
Q
T
R
P
VD
LI
LPL
Q
NQ
L
P
QL
QQ
I
VGV
D
KLAP
A
T
SS
L
-
S
LS
Q
I
I
A
D
----------
N
T
P
L
T
--
TA
I
T
THG
DE
L
A
AV
LFTSGT
E
G
L
PKGV
ML
THNN
ILA
S
E
R
A
Y
CAR
L
N
LT
W
QDV
FM
MPA
P
L
G
H
ATGFLH
G
VT
AP
-----
FL
I
GA
R
S
VL
LDIF
TP
D
AC
LA
L
L
E
Q
Q
R
C
T
C
M
LGA
T
P
F
V
-
Y
D
L
L
N
V
L
E--
K
QP
A
D
L
SA
L
R
F
F
L
C
GG
TT
IP
KKV-
AR
E
C
Q
Q
L
G
I
K
LL
S
VYG
S
TE
SSP
HA
V
VN
---
LDDP
LS
R
----
F
M
HT
D
GY
AA
-
AGV
E
IK
V
V
DD
ARK
T
LP
P
G
C
E
GE
EAS
R
---
GP
NV
F
M
GYF
DE
P
E
L
TA
R
ALD
E
E
GWY
Y
SGDL
CRM
DE
A
GYI
KIT
GR
K
KD
I
I
V
RGGENIS
SR
E
V
E
D
ILL
Q
HPKI
H
DA
C
VV
A
M
P
DE
RL
GE
R
SCAYVVLK
A
P
H
HS
LS
L
EEV
V
A
F
FS
RK
R
V
AK
Y
K
Y
P
EH
I
V
VI
E
K
LPRT
A
SGKI
Q
K
F
L
LR
KDIMR
RLTQDVCEEIE
fig|656443.3.peg.2371
Escherichia coli TA271
MKVTLTFNEQRRAAYR
QQ
G
L
W
G
D
AS
LAD
YW
-
QQ
TA
R
A
MP
D
K
IAVVD
NH
G
AS
Y
T
Y
S
A
L
DH
AA
S
C
LAN
WMLAK
GI
E
S
GD
RI
A
F
QL
P
G
WC
EF
TVI
Y
L
A
C
LKIGA
VS
VP
L
L
P
S
WR
E
A
EL
V
W
V
L
NKC
QA
KMFFAP
T
----
LFK
Q
T
R
P
VD
LI
LPL
Q
NQ
L
P
QL
QQ
I
VGV
D
KLAP
A
T
SS
L
-
S
LS
Q
I
I
A
D
----------
N
T
P
L
T
--
TA
I
T
THG
DE
L
A
AV
LFTSGT
E
G
L
PKGV
ML
THNN
ILA
S
E
R
A
Y
CAR
L
N
LT
W
QDV
FM
MPA
P
L
G
H
ATGFLH
G
VT
AP
-----
FL
I
GA
R
S
VL
LDIF
TP
D
AC
LA
L
L
E
Q
Q
R
C
T
C
M
LGA
T
P
F
V
-
Y
D
L
L
N
V
L
E--
K
QP
A
D
L
SA
L
R
F
F
L
C
GG
TT
IP
KKV-
AR
E
C
Q
Q
L
G
I
K
LL
S
VYG
S
TE
SSP
HA
V
VN
---
LDDP
LS
R
----
F
M
HT
D
GY
AA
-
AGV
E
IK
V
V
DD
ARK
T
LP
P
G
C
E
GE
EAS
R
---
GP
NV
F
M
GYF
DE
P
E
L
TA
R
ALD
E
E
GWY
Y
SGDL
CRM
DE
A
GYI
KIT
GR
K
KD
I
I
V
RGGENIS
SR
E
V
E
D
ILL
Q
HPKI
H
DA
C
VV
A
M
P
DE
RL
GE
R
SCAYVVLK
A
P
H
HS
LS
L
EEV
V
A
F
FS
RK
R
V
AK
Y
K
Y
P
EH
I
V
VI
E
K
LPRT
A
SGKI
Q
K
F
L
LR
KDIMR
RLTQDVCEEIE
fig|340184.3.peg.2929
Escherichia coli B7A (19-566/566)
MKVTLTFNEQRRAAYR
QQ
G
L
W
G
D
AS
LAD
YW
-
QQ
TA
R
A
MP
D
K
IAVVD
NH
G
AS
Y
T
Y
S
A
L
DH
AA
S
C
LAN
WMLAK
GI
E
S
GD
RI
A
F
QL
P
G
WC
EF
TVI
Y
L
A
C
LKIGA
VS
VP
L
L
P
S
WR
E
A
EL
V
W
V
L
NKC
QA
KMFFAP
T
----
LFK
Q
T
R
P
VD
LI
LPL
Q
NQ
L
P
QL
QQ
I
VGV
D
KLAP
A
T
SS
L
-
S
LS
Q
I
I
A
D
----------
N
T
P
L
T
--
TA
I
T
THG
DE
L
A
AV
LFTSGT
E
G
L
PKGV
ML
THNN
ILA
S
E
R
A
Y
CAR
L
N
LT
W
QDV
FM
MPA
P
L
G
H
ATGFLH
G
VT
AP
-----
FL
I
GA
R
S
VL
LDIF
TP
D
AC
LA
L
L
E
Q
Q
R
C
T
C
M
LGA
T
P
F
V
-
Y
D
L
L
N
V
L
E--
K
QP
A
D
L
SA
L
R
F
F
L
C
GG
TT
IP
KKV-
AR
E
C
Q
Q
L
G
I
K
LL
S
VYG
S
TE
SSP
HA
V
VN
---
LDDP
LS
R
----
F
M
HT
D
GY
AA
-
AGV
E
IK
V
V
DD
ARK
T
LP
P
G
C
E
GE
EAS
R
---
GP
NV
F
M
GYF
DE
P
E
L
TA
R
ALD
E
E
GWY
Y
SGDL
CRM
DE
A
GYI
KIT
GR
K
KD
I
I
V
RGGENIS
SR
E
V
E
D
ILL
Q
HPKI
H
DA
C
VV
A
M
P
DE
RL
GE
R
SCAYVVLK
A
P
H
HS
LS
L
EEV
V
A
F
FS
RK
R
V
AK
Y
K
Y
P
EH
I
V
VI
E
K
LPRT
A
SGKI
Q
K
F
L
LR
KDIMR
RLTQDVCEEIE
fig|340186.3.peg.2182
Escherichia coli E110019 (19-566/566)
MKVTLTFNEQRRAAYR
QQ
G
L
W
G
D
AS
LAD
YW
-
QQ
TA
R
A
MP
D
K
IAVVD
NH
G
AS
Y
T
Y
S
A
L
DH
AA
S
C
LAN
WMLAK
GI
E
S
GD
RI
A
F
QL
P
G
WC
EF
TVI
Y
L
A
C
LKIGA
VS
VP
L
L
P
S
WR
E
A
EL
V
W
V
L
NKC
QA
KMFFAP
T
----
LFK
Q
T
R
P
VD
LI
LPL
Q
NQ
L
P
QL
QQ
I
VGV
D
KLAP
A
T
SS
L
-
S
LS
Q
I
I
A
D
----------
N
T
P
L
T
--
TA
I
T
THG
DE
L
A
AV
LFTSGT
E
G
L
PKGV
ML
THNN
ILA
S
E
R
A
Y
CAR
L
N
LT
W
QDV
FM
MPA
P
L
G
H
ATGFLH
G
VT
AP
-----
FL
I
GA
R
S
VL
LDIF
TP
D
AC
LA
L
L
E
Q
Q
R
C
T
C
M
LGA
T
P
F
V
-
Y
D
L
L
N
V
L
E--
K
QP
A
D
L
SA
L
R
F
F
L
C
GG
TT
IP
KKV-
AR
E
C
Q
Q
L
G
I
K
LL
S
VYG
S
TE
SSP
HA
V
VN
---
LDDP
LS
R
----
F
M
HT
D
GY
AA
-
AGV
E
IK
V
V
DD
ARK
T
LP
P
G
C
E
GE
EAS
R
---
GP
NV
F
M
GYF
DE
P
E
L
TA
R
ALD
E
E
GWY
Y
SGDL
CRM
DE
A
GYI
KIT
GR
K
KD
I
I
V
RGGENIS
SR
E
V
E
D
ILL
Q
HPKI
H
DA
C
VV
A
M
P
DE
RL
GE
R
SCAYVVLK
A
P
H
HS
LS
L
EEV
V
A
F
FS
RK
R
V
AK
Y
K
Y
P
EH
I
V
VI
E
K
LPRT
A
SGKI
Q
K
F
L
LR
KDIMR
RLTQDVCEEIE
fig|585034.4.peg.1737
Escherichia coli IAI1
MKVTLTFNEQRRAAYR
QQ
G
L
W
G
D
AS
LAD
YW
-
QQ
TA
R
A
MP
D
K
IAVVD
NH
G
AS
Y
T
Y
S
A
L
DH
AA
S
C
LAN
WMLAK
GI
E
S
GD
RI
A
F
QL
P
G
WC
EF
TVI
Y
L
A
C
LKIGA
VS
VP
L
L
P
S
WR
E
A
EL
V
W
V
L
NKC
QA
KMFFAP
T
----
LFK
Q
T
R
P
VD
LI
LPL
Q
NQ
L
P
QL
QQ
I
VGV
D
KLAP
A
T
SS
L
-
S
LS
Q
I
I
A
D
----------
N
T
S
L
T
--
TA
I
T
THG
DE
L
A
AV
LFTSGT
E
G
L
PKGV
ML
THNN
ILA
S
E
R
A
Y
CVR
L
N
LT
W
QDV
FM
MPA
P
L
G
H
ATGFLH
G
VT
AP
-----
FL
I
GA
R
S
VL
LDIF
TP
D
AC
LA
L
L
E
Q
Q
R
C
T
C
M
LGA
T
P
F
V
-
Y
D
L
L
N
L
L
E--
K
QP
A
D
L
SA
L
R
F
F
L
C
GG
TT
IP
KKV-
AR
E
C
Q
Q
R
G
I
K
LL
S
VYG
S
TE
SSP
HA
V
VN
---
LDDP
LS
R
----
F
M
HT
D
GY
AA
-
AGV
E
IK
V
V
DD
ARK
T
LP
P
G
C
E
GE
EAS
R
---
GP
NV
F
M
GYF
DE
P
E
L
TA
R
ALD
E
E
GWY
Y
SGDL
CRM
DE
A
GYI
KIT
GR
K
KD
I
I
V
RGGENIS
SR
E
V
E
D
ILL
Q
HPKI
H
DA
C
VV
A
M
P
DE
RL
GE
R
SCAYVVLK
A
P
H
HS
LS
L
EEV
V
A
F
FS
RK
R
V
AK
Y
K
Y
P
EH
I
V
VI
E
K
LPRT
A
SGKI
Q
K
F
L
LR
KDIMR
RLTQDVCEEIE
fig|585034.5.peg.1732
Escherichia coli IAI1
MKVTLTFNEQRRAAYR
QQ
G
L
W
G
D
AS
LAD
YW
-
QQ
TA
R
A
MP
D
K
IAVVD
NH
G
AS
Y
T
Y
S
A
L
DH
AA
S
C
LAN
WMLAK
GI
E
S
GD
RI
A
F
QL
P
G
WC
EF
TVI
Y
L
A
C
LKIGA
VS
VP
L
L
P
S
WR
E
A
EL
V
W
V
L
NKC
QA
KMFFAP
T
----
LFK
Q
T
R
P
VD
LI
LPL
Q
NQ
L
P
QL
QQ
I
VGV
D
KLAP
A
T
SS
L
-
S
LS
Q
I
I
A
D
----------
N
T
S
L
T
--
TA
I
T
THG
DE
L
A
AV
LFTSGT
E
G
L
PKGV
ML
THNN
ILA
S
E
R
A
Y
CVR
L
N
LT
W
QDV
FM
MPA
P
L
G
H
ATGFLH
G
VT
AP
-----
FL
I
GA
R
S
VL
LDIF
TP
D
AC
LA
L
L
E
Q
Q
R
C
T
C
M
LGA
T
P
F
V
-
Y
D
L
L
N
L
L
E--
K
QP
A
D
L
SA
L
R
F
F
L
C
GG
TT
IP
KKV-
AR
E
C
Q
Q
R
G
I
K
LL
S
VYG
S
TE
SSP
HA
V
VN
---
LDDP
LS
R
----
F
M
HT
D
GY
AA
-
AGV
E
IK
V
V
DD
ARK
T
LP
P
G
C
E
GE
EAS
R
---
GP
NV
F
M
GYF
DE
P
E
L
TA
R
ALD
E
E
GWY
Y
SGDL
CRM
DE
A
GYI
KIT
GR
K
KD
I
I
V
RGGENIS
SR
E
V
E
D
ILL
Q
HPKI
H
DA
C
VV
A
M
P
DE
RL
GE
R
SCAYVVLK
A
P
H
HS
LS
L
EEV
V
A
F
FS
RK
R
V
AK
Y
K
Y
P
EH
I
V
VI
E
K
LPRT
A
SGKI
Q
K
F
L
LR
KDIMR
RLTQDVCEEIE
fig|656408.3.peg.1857
Escherichia coli H591
MKVTLTFNEQRRAAYR
QQ
G
L
W
G
D
AS
LAD
YW
-
QQ
TA
R
A
MP
D
K
IAVVD
NH
G
AS
Y
N
Y
S
A
L
DH
AA
S
C
LAN
WMLAK
GI
E
S
GD
RI
A
F
QL
P
G
WC
EF
TVI
Y
L
A
C
LKIGA
VS
VP
L
L
P
S
WR
E
A
EL
V
W
V
L
NKC
QA
KMFFAP
T
----
LFK
Q
T
R
P
VD
LI
LPL
Q
NQ
L
P
QL
QQ
I
VGV
D
KLAP
A
T
SS
L
-
S
LS
Q
I
I
A
D
----------
N
T
P
L
T
--
TA
I
T
THG
DE
L
A
AV
LFTSGT
E
G
L
PKGV
ML
THNN
ILA
S
E
R
A
Y
CAR
L
N
LT
W
QDV
FM
MPA
P
L
G
H
ATGFLH
G
VT
AP
-----
FL
I
GA
R
S
VL
LDIF
TP
D
AC
LA
L
L
E
Q
Q
R
C
T
C
M
LGA
T
P
F
V
-
Y
D
L
L
N
V
L
E--
K
QP
A
D
L
SA
L
R
F
F
L
C
GG
TT
IP
KKV-
AR
E
C
Q
Q
L
G
I
K
LL
S
VYG
S
TE
SSP
HA
V
VN
---
LDDP
LS
R
----
F
M
HT
D
GY
AA
-
AGV
E
IK
V
V
DD
ARK
T
LP
P
G
C
E
GE
EAS
R
---
GP
NV
F
M
GYF
DE
P
E
L
TA
R
ALD
E
E
GWY
Y
SGDL
CRM
DE
A
GYI
KIT
GR
K
KD
I
I
V
RGGENIS
SR
E
V
E
D
ILL
Q
HPKI
H
DA
C
VV
A
M
P
DE
RL
GE
R
SCAYVVLK
A
P
H
HS
LS
L
EEV
V
A
F
FS
RK
R
V
AK
Y
K
Y
P
EH
I
V
VI
E
K
LPRT
A
SGKI
Q
K
F
L
LR
KDIMR
RLTQDVCEEIE
fig|679206.4.peg.1191
Escherichia coli MS 119-7
MKVTLTFNEQRRAAYR
QQ
G
L
W
G
D
AS
LAD
YW
-
QQ
TA
R
A
MP
D
K
IAVVD
NH
G
AS
Y
N
Y
S
A
L
DH
AA
S
C
LAN
WMLAK
GI
E
S
GD
RI
A
F
QL
P
G
WC
EF
TVI
Y
L
A
C
LKIGA
VS
VP
L
L
P
S
WR
E
A
EL
V
W
V
L
NKC
QA
KMFFAP
T
----
LFK
Q
T
R
P
VD
LI
LPL
Q
NQ
L
P
QL
QQ
I
VGV
D
KLAP
A
T
SS
L
-
S
LS
Q
I
I
A
D
----------
N
T
P
L
T
--
TA
I
T
THG
DE
L
A
AV
LFTSGT
E
G
L
PKGV
ML
THNN
ILA
S
E
R
A
Y
CAR
L
N
LT
W
QDV
FM
MPA
P
L
G
H
ATGFLH
G
VT
AP
-----
FL
I
GA
R
S
VL
LDIF
TP
D
AC
LA
L
L
E
Q
Q
R
C
T
C
M
LGA
T
P
F
V
-
Y
D
L
L
N
V
L
E--
K
QP
A
D
L
SA
L
R
F
F
L
C
GG
TT
IP
KKV-
AR
E
C
Q
Q
L
G
I
K
LL
S
VYG
S
TE
SSP
HA
V
VN
---
LDDP
LS
R
----
F
M
HT
D
GY
AA
-
AGV
E
IK
V
V
DD
ARK
T
LP
P
G
C
E
GE
EAS
R
---
GP
NV
F
M
GYF
DE
P
E
L
TA
R
ALD
E
E
GWY
Y
SGDL
CRM
DE
A
GYI
KIT
GR
K
KD
I
I
V
RGGENIS
SR
E
V
E
D
ILL
Q
HPKI
H
DA
C
VV
A
M
P
DE
RL
GE
R
SCAYVVLK
A
P
H
HS
LS
L
EEV
V
A
F
FS
RK
R
V
AK
Y
K
Y
P
EH
I
V
VI
E
K
LPRT
A
SGKI
Q
K
F
L
LR
KDIMR
RLTQDVCEEIE
fig|585396.4.peg.2255
Escherichia coli O111:H- str. 11128
MKVTLTFNEQRRAAYR
QQ
G
L
W
G
D
AS
LAD
YW
-
QQ
TA
R
A
MP
D
K
IAVVD
NH
G
AS
Y
T
Y
S
A
L
DH
AA
S
C
LAN
WMLAK
GI
E
S
GD
RI
A
F
QL
P
G
WC
EF
TVI
Y
L
A
C
LKIGA
VS
VP
L
L
P
S
WR
E
A
EL
V
W
V
L
NKC
QA
KMFFAP
T
----
LFK
Q
T
R
P
VD
LI
LPL
Q
NQ
L
P
QL
QQ
I
VGV
D
KLAP
A
T
SS
L
-
S
LS
Q
I
I
A
D
----------
N
T
P
L
T
--
TA
I
T
THG
DE
L
A
AV
LFTSG
I
E
G
L
PKGV
ML
THNN
ILA
S
E
R
A
Y
CAR
L
N
LT
W
QDV
FM
MPA
P
L
G
H
ATGFLH
G
VT
AP
-----
FL
I
GA
R
S
VL
LDIF
TP
D
AC
LA
L
L
E
Q
Q
R
C
T
C
M
LGA
T
P
F
V
-
Y
D
L
L
N
V
L
E--
K
QP
A
D
L
SA
L
R
F
F
L
C
GG
TT
IP
KKV-
AR
E
C
Q
Q
L
G
I
K
LL
S
VYG
S
TE
SSP
HA
V
VN
---
LDDP
LS
R
----
F
M
HT
D
GY
AA
-
AGV
E
IK
V
V
DD
ARK
T
LP
P
G
C
E
GE
EAS
R
---
GP
NV
F
M
GYF
DE
P
E
L
TA
R
ALD
E
E
GWY
Y
SGDL
CRM
DE
A
GYI
KIT
GR
K
KD
I
I
V
RGGENIS
SR
E
V
E
D
ILL
Q
HPKI
H
DA
C
VV
A
M
P
DE
RL
GE
R
SCAYVVLK
A
P
H
HS
LS
L
EEV
V
A
F
FS
RK
R
V
AK
Y
K
Y
P
EH
I
V
VI
E
K
LPRT
A
SGKI
Q
K
F
L
LR
KDIMR
RLTQDVCEEIE
fig|562.375.peg.1812
Escherichia coli EC4100B
MKVTLTFNEQRRAAYR
QQ
G
L
W
G
D
AS
LAD
YW
-
QQ
TA
R
A
MP
D
K
IAVVD
NH
G
AS
Y
T
Y
S
A
L
DH
AA
S
C
LAN
WMLAK
GI
E
S
GD
RI
A
F
QL
P
G
WC
EF
TVI
Y
L
A
C
LK
T
GA
VS
VP
L
L
P
S
WR
E
A
EL
V
W
V
L
NKC
QA
KMFFAP
T
----
LFK
Q
T
R
P
VD
LI
LPL
Q
NQ
L
P
QL
QQ
I
VGV
D
KLAP
A
T
SS
L
-
S
LS
Q
I
I
A
D
----------
N
T
S
L
T
--
TA
I
T
THG
DE
L
A
AV
LFTSGT
E
G
L
PKGV
ML
THNN
ILA
S
E
R
A
Y
CAR
L
N
LT
W
QDV
FM
MPA
P
L
G
H
ATGFLH
G
VT
AP
-----
FL
I
GA
R
S
VL
LDIF
TP
D
AC
LA
L
L
E
Q
Q
R
C
T
C
M
LGA
T
P
F
V
-
Y
D
L
L
N
V
L
E--
K
QP
A
D
L
SA
L
R
F
F
L
C
GG
TT
IP
KKV-
AR
E
C
Q
Q
R
G
I
K
LL
S
VYG
S
TE
SSP
HA
V
VN
---
LDDP
LS
R
----
F
M
HT
D
GY
AA
-
AGV
E
IK
V
V
DD
ARK
T
LP
P
G
C
E
GE
EAS
R
---
GP
NV
F
M
GYF
DE
P
E
L
TA
R
ALD
E
E
GWY
Y
SGDL
CRM
DE
A
GYI
KIT
GR
K
KD
I
I
V
RGGENIS
SR
E
V
E
D
ILL
Q
HPKI
H
DA
C
VV
A
M
P
DE
RL
GE
R
SCAYVVLK
A
P
H
HS
LS
L
EEV
V
A
F
FS
RK
R
V
AK
Y
K
Y
P
EH
I
V
VI
E
K
LPRT
A
SGKI
Q
K
F
L
LR
KDIMR
RLTQDVCEEIE
fig|679207.4.peg.3292
Escherichia coli MS 107-1
MKVTLTFNEQRRAAYR
QQ
G
L
W
G
D
AS
LAD
YW
-
QQ
TA
R
A
MP
D
K
IAVVD
NH
G
AS
Y
T
Y
S
A
L
DH
AA
S
C
LAN
WMLAK
GI
E
S
GD
RI
A
F
QL
P
G
WC
EF
TVI
Y
L
A
C
LK
T
GA
VS
VP
L
L
P
S
WR
E
A
EL
V
W
V
L
NKC
QA
KMFFAP
T
----
LFK
Q
T
R
P
VD
LI
LPL
Q
NQ
L
P
QL
QQ
I
VGV
D
KLAP
A
T
SS
L
-
S
LS
Q
I
I
A
D
----------
N
T
S
L
T
--
TA
I
T
THG
DE
L
A
AV
LFTSGT
E
G
L
PKGV
ML
THNN
ILA
S
E
R
A
Y
CAR
L
N
LT
W
QDV
FM
MPA
P
L
G
H
ATGFLH
G
VT
AP
-----
FL
I
GA
R
S
VL
LDIF
TP
D
AC
LA
L
L
E
Q
Q
R
C
T
C
M
LGA
T
P
F
V
-
Y
D
L
L
N
V
L
E--
K
QP
A
D
L
SA
L
R
F
F
L
C
GG
TT
IP
KKV-
AR
E
C
Q
Q
R
G
I
K
LL
S
VYG
S
TE
SSP
HA
V
VN
---
LDDP
LS
R
----
F
M
HT
D
GY
AA
-
AGV
E
IK
V
V
DD
ARK
T
LP
P
G
C
E
GE
EAS
R
---
GP
NV
F
M
GYF
DE
P
E
L
TA
R
ALD
E
E
GWY
Y
SGDL
CRM
DE
A
GYI
KIT
GR
K
KD
I
I
V
RGGENIS
SR
E
V
E
D
ILL
Q
HPKI
H
DA
C
VV
A
M
P
DE
RL
GE
R
SCAYVVLK
A
P
H
HS
LS
L
EEV
V
A
F
FS
RK
R
V
AK
Y
K
Y
P
EH
I
V
VI
E
K
LPRT
A
SGKI
Q
K
F
L
LR
KDIMR
RLTQDVCEEIE
fig|679205.4.peg.5049
Escherichia coli MS 124-1
MKVTLTFNEQRRAAYR
QQ
G
L
W
G
D
AS
LAD
YW
-
QQ
TA
R
A
MP
D
K
IAVVD
NH
G
AS
Y
T
Y
S
A
L
DH
AA
S
C
LAN
WMLAK
GI
E
S
GD
RI
A
F
QL
P
G
WC
EF
TVI
Y
L
A
C
LK
T
GA
VS
VP
L
L
P
S
WR
E
A
EL
V
W
V
L
NKC
QA
KMFFAP
T
----
LFK
Q
T
R
P
VD
LI
LPL
Q
NQ
L
P
QL
QQ
I
VGV
D
KLAP
A
T
SS
L
-
S
LS
Q
I
I
A
D
----------
N
T
S
L
T
--
TA
I
T
THG
DE
L
A
AV
LFTSGT
E
G
L
PKGV
ML
THNN
ILA
S
E
R
A
Y
CAR
L
N
LT
W
QDV
FM
MPA
P
L
G
H
ATGFLH
G
VT
AP
-----
FL
I
GA
R
S
VL
LDIF
TP
D
AC
LA
L
L
E
Q
Q
R
C
T
C
M
LGA
T
P
F
V
-
Y
D
L
L
N
V
L
E--
K
QP
A
D
L
SA
L
R
F
F
L
C
GG
TT
IP
KKV-
AR
E
C
Q
Q
R
G
I
K
LL
S
VYG
S
TE
SSP
HA
V
VN
---
LDDP
LS
R
----
F
M
HT
D
GY
AA
-
AGV
E
IK
V
V
DD
ARK
T
LP
P
G
C
E
GE
EAS
R
---
GP
NV
F
M
GYF
DE
P
E
L
TA
R
ALD
E
E
GWY
Y
SGDL
CRM
DE
A
GYI
KIT
GR
K
KD
I
I
V
RGGENIS
SR
E
V
E
D
ILL
Q
HPKI
H
DA
C
VV
A
M
P
DE
RL
GE
R
SCAYVVLK
A
P
H
HS
LS
L
EEV
V
A
F
FS
RK
R
V
AK
Y
K
Y
P
EH
I
V
VI
E
K
LPRT
A
SGKI
Q
K
F
L
LR
KDIMR
RLTQDVCEEIE
fig|749533.3.peg.2660
Escherichia coli MS 84-1
MKVTLTFNEQRRAAYR
QQ
G
L
W
G
D
AS
LAD
YW
-
QQ
TA
R
A
MP
D
K
IAVVD
NH
G
AS
Y
T
Y
S
A
L
DH
AA
S
C
LAN
WMLAK
GI
E
S
GD
RI
A
F
QL
P
G
WC
EF
TVI
Y
L
A
C
LK
T
GA
VS
VP
L
L
P
S
WR
E
A
EL
V
W
V
L
NKC
QA
KMFFAP
T
----
LFK
Q
T
R
P
VD
LI
LPL
Q
NQ
L
P
QL
QQ
I
VGV
D
KLAP
A
T
SS
L
-
S
LS
Q
I
I
A
D
----------
N
T
S
L
T
--
TA
I
T
THG
DE
L
A
AV
LFTSGT
E
G
L
PKGV
ML
THNN
ILA
S
E
R
A
Y
CAR
L
N
LT
W
QDV
FM
MPA
P
L
G
H
ATGFLH
G
VT
AP
-----
FL
I
GA
R
S
VL
LDIF
TP
D
AC
LA
L
L
E
Q
Q
R
C
T
C
M
LGA
T
P
F
V
-
Y
D
L
L
N
V
L
E--
K
QP
A
D
L
SA
L
R
F
F
L
C
GG
TT
IP
KKV-
AR
E
C
Q
Q
R
G
I
K
LL
S
VYG
S
TE
SSP
HA
V
VN
---
LDDP
LS
R
----
F
M
HT
D
GY
AA
-
AGV
E
IK
V
V
DD
ARK
T
LP
P
G
C
E
GE
EAS
R
---
GP
NV
F
M
GYF
DE
P
E
L
TA
R
ALD
E
E
GWY
Y
SGDL
CRM
DE
A
GYI
KIT
GR
K
KD
I
I
V
RGGENIS
SR
E
V
E
D
ILL
Q
HPKI
H
DA
C
VV
A
M
P
DE
RL
GE
R
SCAYVVLK
A
P
H
HS
LS
L
EEV
V
A
F
FS
RK
R
V
AK
Y
K
Y
P
EH
I
V
VI
E
K
LPRT
A
SGKI
Q
K
F
L
LR
KDIMR
RLTQDVCEEIE
fig|331111.3.peg.4343
Escherichia coli E24377A (19-566/566)
MKVTLTFNEQRRAAYR
QQ
G
L
W
G
D
AS
LAD
YW
-
QQ
TA
R
A
MP
D
K
IAVVD
NH
G
AS
Y
T
Y
S
A
L
DH
AA
S
C
LAN
WMLAK
GI
E
S
GD
RI
A
F
QL
P
G
WC
EF
TVI
Y
L
A
C
LKIGA
VS
VP
L
L
P
S
WR
E
A
EL
V
W
V
L
NKC
QA
KMFFAP
T
----
LFK
Q
T
R
P
VD
LI
LPL
Q
NQ
L
P
QL
QQ
I
VGV
D
KLAP
A
T
SS
L
-
S
LS
Q
I
I
A
D
----------
N
T
P
L
T
--
TA
I
T
THG
DE
L
A
AV
LFTSGT
E
G
L
PKGV
ML
THNN
ILA
S
E
R
A
Y
CAR
L
N
LT
W
QDV
FM
MPA
P
L
G
H
ATGFLH
G
VT
AP
-----
FL
I
GA
R
S
VL
LDIF
TP
D
AC
LA
L
L
E
Q
Q
R
C
T
C
M
LGA
T
P
F
V
-
Y
D
L
L
N
V
L
E--
K
QP
A
D
L
SA
L
R
F
F
L
C
GG
TT
IP
KKV-
AR
E
C
Q
Q
L
G
I
K
LL
S
VYG
S
TE
SSP
HA
E
VN
---
LDDP
LS
R
----
F
M
HT
D
GY
AA
-
AGV
E
IK
V
V
DD
ARK
T
LP
P
G
C
E
GE
EAS
R
---
GP
NV
F
M
GYF
DE
P
E
L
TA
R
ALD
E
E
GWY
Y
SGDL
CRM
DE
A
GYI
KIT
GR
K
KD
I
I
V
RGGENIS
SR
E
V
E
D
ILL
Q
HPKI
H
DA
C
VV
A
M
P
DE
RL
GE
R
SCAYVVLK
A
P
H
HS
LS
L
EEV
V
A
F
FS
RK
R
V
AK
Y
K
Y
P
EH
I
V
VI
E
K
LPRT
A
SGKI
Q
K
F
L
LR
KDIMR
RLTQDVCEEIE
fig|331111.12.peg.2199
Escherichia coli E24377A
MKVTLTFNEQRRAAYR
QQ
G
L
W
G
D
AS
LAD
YW
-
QQ
TA
R
A
MP
D
K
IAVVD
NH
G
AS
Y
T
Y
S
A
L
DH
AA
S
C
LAN
WMLAK
GI
E
S
GD
RI
A
F
QL
P
G
WC
EF
TVI
Y
L
A
C
LKIGA
VS
VP
L
L
P
S
WR
E
A
EL
V
W
V
L
NKC
QA
KMFFAP
T
----
LFK
Q
T
R
P
VD
LI
LPL
Q
NQ
L
P
QL
QQ
I
VGV
D
KLAP
A
T
SS
L
-
S
LS
Q
I
I
A
D
----------
N
T
P
L
T
--
TA
I
T
THG
DE
L
A
AV
LFTSGT
E
G
L
PKGV
ML
THNN
ILA
S
E
R
A
Y
CAR
L
N
LT
W
QDV
FM
MPA
P
L
G
H
ATGFLH
G
VT
AP
-----
FL
I
GA
R
S
VL
LDIF
TP
D
AC
LA
L
L
E
Q
Q
R
C
T
C
M
LGA
T
P
F
V
-
Y
D
L
L
N
V
L
E--
K
QP
A
D
L
SA
L
R
F
F
L
C
GG
TT
IP
KKV-
AR
E
C
Q
Q
L
G
I
K
LL
S
VYG
S
TE
SSP
HA
E
VN
---
LDDP
LS
R
----
F
M
HT
D
GY
AA
-
AGV
E
IK
V
V
DD
ARK
T
LP
P
G
C
E
GE
EAS
R
---
GP
NV
F
M
GYF
DE
P
E
L
TA
R
ALD
E
E
GWY
Y
SGDL
CRM
DE
A
GYI
KIT
GR
K
KD
I
I
V
RGGENIS
SR
E
V
E
D
ILL
Q
HPKI
H
DA
C
VV
A
M
P
DE
RL
GE
R
SCAYVVLK
A
P
H
HS
LS
L
EEV
V
A
F
FS
RK
R
V
AK
Y
K
Y
P
EH
I
V
VI
E
K
LPRT
A
SGKI
Q
K
F
L
LR
KDIMR
RLTQDVCEEIE
fig|525281.3.peg.802
Escherichia coli 83972
MKVTLTFNEQRRAAYR
QQ
G
L
W
G
D
AS
LAD
YW
-
QQ
TA
R
A
MP
D
K
IAVVD
NH
G
AT
Y
T
Y
S
A
L
DH
AA
S
C
LAN
WMLAK
GI
E
S
GD
RI
A
F
QL
P
G
WC
EF
TVI
Y
L
A
C
LK
T
GA
VS
VP
L
L
P
S
WR
E
A
EL
V
W
V
L
NKC
QA
KMFFAP
T
----
LFK
Q
T
R
P
VD
LI
LPL
Q
NQ
L
P
QL
QQ
I
VGV
D
KLAP
A
T
SS
L
-
S
LS
Q
I
L
A
D
----------
N
T
P
L
T
--
TA
I
T
THG
DE
L
A
AV
LFTSGT
E
G
L
PKGV
ML
THNN
ILA
S
E
R
A
Y
CAR
L
N
LT
W
QDV
FM
MPA
P
L
G
H
ATGFLH
G
VT
AP
-----
FL
I
GA
R
S
VL
LDIF
TP
D
AC
LA
L
L
E
Q
Q
R
C
T
C
M
LGA
T
P
F
V
-
Y
D
L
L
N
L
L
E--
K
QP
A
D
L
SA
L
R
F
F
L
C
GG
TT
IP
KKV-
AR
E
C
Q
Q
R
G
I
K
LL
S
VYG
S
TE
SSP
HA
V
VN
---
LDDP
LP
R
----
F
M
HT
D
GY
AA
-
AGV
E
IK
V
V
DD
ARK
T
LP
P
G
C
E
GE
EAS
R
---
GP
NV
F
M
GYF
DE
P
E
L
TA
R
ALD
E
E
GWY
Y
SGDL
CRM
DE
A
GYI
KIT
GR
K
KD
I
I
V
RGGENIS
SR
E
V
E
D
ILL
Q
HPKI
H
DA
C
VV
A
M
P
DE
RL
GE
R
SCAYVVLK
A
P
H
HS
LS
L
EEV
V
A
F
FS
RK
R
V
AK
Y
K
Y
P
EH
I
V
VI
E
K
LPRT
V
SGKI
Q
K
F
L
LR
KDIMR
RLTQDVCEEIE
fig|655817.3.peg.2047
Escherichia coli ABU 83972
MKVTLTFNEQRRAAYR
QQ
G
L
W
G
D
AS
LAD
YW
-
QQ
TA
R
A
MP
D
K
IAVVD
NH
G
AT
Y
T
Y
S
A
L
DH
AA
S
C
LAN
WMLAK
GI
E
S
GD
RI
A
F
QL
P
G
WC
EF
TVI
Y
L
A
C
LK
T
GA
VS
VP
L
L
P
S
WR
E
A
EL
V
W
V
L
NKC
QA
KMFFAP
T
----
LFK
Q
T
R
P
VD
LI
LPL
Q
NQ
L
P
QL
QQ
I
VGV
D
KLAP
A
T
SS
L
-
S
LS
Q
I
L
A
D
----------
N
T
P
L
T
--
TA
I
T
THG
DE
L
A
AV
LFTSGT
E
G
L
PKGV
ML
THNN
ILA
S
E
R
A
Y
CAR
L
N
LT
W
QDV
FM
MPA
P
L
G
H
ATGFLH
G
VT
AP
-----
FL
I
GA
R
S
VL
LDIF
TP
D
AC
LA
L
L
E
Q
Q
R
C
T
C
M
LGA
T
P
F
V
-
Y
D
L
L
N
L
L
E--
K
QP
A
D
L
SA
L
R
F
F
L
C
GG
TT
IP
KKV-
AR
E
C
Q
Q
R
G
I
K
LL
S
VYG
S
TE
SSP
HA
V
VN
---
LDDP
LP
R
----
F
M
HT
D
GY
AA
-
AGV
E
IK
V
V
DD
ARK
T
LP
P
G
C
E
GE
EAS
R
---
GP
NV
F
M
GYF
DE
P
E
L
TA
R
ALD
E
E
GWY
Y
SGDL
CRM
DE
A
GYI
KIT
GR
K
KD
I
I
V
RGGENIS
SR
E
V
E
D
ILL
Q
HPKI
H
DA
C
VV
A
M
P
DE
RL
GE
R
SCAYVVLK
A
P
H
HS
LS
L
EEV
V
A
F
FS
RK
R
V
AK
Y
K
Y
P
EH
I
V
VI
E
K
LPRT
V
SGKI
Q
K
F
L
LR
KDIMR
RLTQDVCEEIE
fig|405955.13.peg.1790
Escherichia coli APEC O1
MKVTLTFNEQRRAAYR
QQ
G
L
W
G
D
AS
LAD
YW
-
QQ
TA
R
A
MP
D
K
IAVVD
NH
G
AT
Y
T
Y
S
A
L
DH
AA
S
C
LAN
WMLAK
GI
E
S
GD
RI
A
F
QL
P
G
WC
EF
TVI
Y
L
A
C
LK
T
GA
VS
VP
L
L
P
S
WR
E
A
EL
V
W
V
L
NKC
QA
KMFFAP
T
----
LFK
Q
T
R
P
VD
LI
LPL
Q
NQ
L
P
QL
QQ
I
VGV
D
KLAP
A
T
SS
L
-
S
LS
Q
I
L
A
D
----------
N
T
P
L
T
--
TA
I
T
THG
DE
L
A
AV
LFTSGT
E
G
L
PKGV
ML
THNN
ILA
S
E
R
A
Y
CAR
L
N
LT
W
QDV
FM
MPA
P
L
G
H
ATGFLH
G
VT
AP
-----
FL
I
GA
R
S
VL
LDIF
TP
D
AC
LA
L
L
E
Q
Q
R
C
T
C
M
LGA
T
P
F
V
-
Y
D
L
L
N
L
L
E--
K
QP
A
D
L
SA
L
R
F
F
L
C
GG
TT
IP
KKV-
AR
E
C
Q
Q
R
G
I
K
LL
S
VYG
S
TE
SSP
HA
V
VN
---
LDDP
LP
R
----
F
M
HT
D
GY
AA
-
AGV
E
IK
V
V
DD
ARK
T
LP
P
G
C
E
GE
EAS
R
---
GP
NV
F
M
GYF
DE
P
E
L
TA
R
ALD
E
E
GWY
Y
SGDL
CRM
DE
A
GYI
KIT
GR
K
KD
I
I
V
RGGENIS
SR
E
V
E
D
ILL
Q
HPKI
H
DA
C
VV
A
M
P
DE
RL
GE
R
SCAYVVLK
A
P
H
HS
LS
L
EEV
V
A
F
FS
RK
R
V
AK
Y
K
Y
P
EH
I
V
VI
E
K
LPRT
V
SGKI
Q
K
F
L
LR
KDIMR
RLTQDVCEEIE
fig|199310.4.peg.1963
Escherichia coli CFT073
MKVTLTFNEQRRAAYR
QQ
G
L
W
G
D
AS
LAD
YW
-
QQ
TA
R
A
MP
D
K
IAVVD
NH
G
AT
Y
T
Y
S
A
L
DH
AA
S
C
LAN
WMLAK
GI
E
S
GD
RI
A
F
QL
P
G
WC
EF
TVI
Y
L
A
C
LK
T
GA
VS
VP
L
L
P
S
WR
E
A
EL
V
W
V
L
NKC
QA
KMFFAP
T
----
LFK
Q
T
R
P
VD
LI
LPL
Q
NQ
L
P
QL
QQ
I
VGV
D
KLAP
A
T
SS
L
-
S
LS
Q
I
L
A
D
----------
N
T
P
L
T
--
TA
I
T
THG
DE
L
A
AV
LFTSGT
E
G
L
PKGV
ML
THNN
ILA
S
E
R
A
Y
CAR
L
N
LT
W
QDV
FM
MPA
P
L
G
H
ATGFLH
G
VT
AP
-----
FL
I
GA
R
S
VL
LDIF
TP
D
AC
LA
L
L
E
Q
Q
R
C
T
C
M
LGA
T
P
F
V
-
Y
D
L
L
N
L
L
E--
K
QP
A
D
L
SA
L
R
F
F
L
C
GG
TT
IP
KKV-
AR
E
C
Q
Q
R
G
I
K
LL
S
VYG
S
TE
SSP
HA
V
VN
---
LDDP
LP
R
----
F
M
HT
D
GY
AA
-
AGV
E
IK
V
V
DD
ARK
T
LP
P
G
C
E
GE
EAS
R
---
GP
NV
F
M
GYF
DE
P
E
L
TA
R
ALD
E
E
GWY
Y
SGDL
CRM
DE
A
GYI
KIT
GR
K
KD
I
I
V
RGGENIS
SR
E
V
E
D
ILL
Q
HPKI
H
DA
C
VV
A
M
P
DE
RL
GE
R
SCAYVVLK
A
P
H
HS
LS
L
EEV
V
A
F
FS
RK
R
V
AK
Y
K
Y
P
EH
I
V
VI
E
K
LPRT
V
SGKI
Q
K
F
L
LR
KDIMR
RLTQDVCEEIE
fig|585397.7.peg.1926
Escherichia coli ED1a
MKVTLTFNEQRRAAYR
QQ
G
L
W
G
D
AS
LAD
YW
-
QQ
TA
R
A
MP
D
K
IAVVD
NH
G
AT
Y
T
Y
S
A
L
DH
AA
S
C
LAN
WMLAK
GI
E
S
GD
RI
A
F
QL
P
G
WC
EF
TVI
Y
L
A
C
LK
T
GA
VS
VP
L
L
P
S
WR
E
A
EL
V
W
V
L
NKC
QA
KMFFAP
T
----
LFK
Q
T
R
P
VD
LI
LPL
Q
NQ
L
P
QL
QQ
I
VGV
D
KLAP
A
T
SS
L
-
S
LS
Q
I
L
A
D
----------
N
T
P
L
T
--
TA
I
T
THG
DE
L
A
AV
LFTSGT
E
G
L
PKGV
ML
THNN
ILA
S
E
R
A
Y
CAR
L
N
LT
W
QDV
FM
MPA
P
L
G
H
ATGFLH
G
VT
AP
-----
FL
I
GA
R
S
VL
LDIF
TP
D
AC
LA
L
L
E
Q
Q
R
C
T
C
M
LGA
T
P
F
V
-
Y
D
L
L
N
L
L
E--
K
QP
A
D
L
SA
L
R
F
F
L
C
GG
TT
IP
KKV-
AR
E
C
Q
Q
R
G
I
K
LL
S
VYG
S
TE
SSP
HA
V
VN
---
LDDP
LP
R
----
F
M
HT
D
GY
AA
-
AGV
E
IK
V
V
DD
ARK
T
LP
P
G
C
E
GE
EAS
R
---
GP
NV
F
M
GYF
DE
P
E
L
TA
R
ALD
E
E
GWY
Y
SGDL
CRM
DE
A
GYI
KIT
GR
K
KD
I
I
V
RGGENIS
SR
E
V
E
D
ILL
Q
HPKI
H
DA
C
VV
A
M
P
DE
RL
GE
R
SCAYVVLK
A
P
H
HS
LS
L
EEV
V
A
F
FS
RK
R
V
AK
Y
K
Y
P
EH
I
V
VI
E
K
LPRT
V
SGKI
Q
K
F
L
LR
KDIMR
RLTQDVCEEIE
fig|585397.9.peg.1921
Escherichia coli ED1a
MKVTLTFNEQRRAAYR
QQ
G
L
W
G
D
AS
LAD
YW
-
QQ
TA
R
A
MP
D
K
IAVVD
NH
G
AT
Y
T
Y
S
A
L
DH
AA
S
C
LAN
WMLAK
GI
E
S
GD
RI
A
F
QL
P
G
WC
EF
TVI
Y
L
A
C
LK
T
GA
VS
VP
L
L
P
S
WR
E
A
EL
V
W
V
L
NKC
QA
KMFFAP
T
----
LFK
Q
T
R
P
VD
LI
LPL
Q
NQ
L
P
QL
QQ
I
VGV
D
KLAP
A
T
SS
L
-
S
LS
Q
I
L
A
D
----------
N
T
P
L
T
--
TA
I
T
THG
DE
L
A
AV
LFTSGT
E
G
L
PKGV
ML
THNN
ILA
S
E
R
A
Y
CAR
L
N
LT
W
QDV
FM
MPA
P
L
G
H
ATGFLH
G
VT
AP
-----
FL
I
GA
R
S
VL
LDIF
TP
D
AC
LA
L
L
E
Q
Q
R
C
T
C
M
LGA
T
P
F
V
-
Y
D
L
L
N
L
L
E--
K
QP
A
D
L
SA
L
R
F
F
L
C
GG
TT
IP
KKV-
AR
E
C
Q
Q
R
G
I
K
LL
S
VYG
S
TE
SSP
HA
V
VN
---
LDDP
LP
R
----
F
M
HT
D
GY
AA
-
AGV
E
IK
V
V
DD
ARK
T
LP
P
G
C
E
GE
EAS
R
---
GP
NV
F
M
GYF
DE
P
E
L
TA
R
ALD
E
E
GWY
Y
SGDL
CRM
DE
A
GYI
KIT
GR
K
KD
I
I
V
RGGENIS
SR
E
V
E
D
ILL
Q
HPKI
H
DA
C
VV
A
M
P
DE
RL
GE
R
SCAYVVLK
A
P
H
HS
LS
L
EEV
V
A
F
FS
RK
R
V
AK
Y
K
Y
P
EH
I
V
VI
E
K
LPRT
V
SGKI
Q
K
F
L
LR
KDIMR
RLTQDVCEEIE
fig|714962.3.peg.1856
Escherichia coli IHE3034
MKVTLTFNEQRRAAYR
QQ
G
L
W
G
D
AS
LAD
YW
-
QQ
TA
R
A
MP
D
K
IAVVD
NH
G
AT
Y
T
Y
S
A
L
DH
AA
S
C
LAN
WMLAK
GI
E
S
GD
RI
A
F
QL
P
G
WC
EF
TVI
Y
L
A
C
LK
T
GA
VS
VP
L
L
P
S
WR
E
A
EL
V
W
V
L
NKC
QA
KMFFAP
T
----
LFK
Q
T
R
P
VD
LI
LPL
Q
NQ
L
P
QL
QQ
I
VGV
D
KLAP
A
T
SS
L
-
S
LS
Q
I
L
A
D
----------
N
T
P
L
T
--
TA
I
T
THG
DE
L
A
AV
LFTSGT
E
G
L
PKGV
ML
THNN
ILA
S
E
R
A
Y
CAR
L
N
LT
W
QDV
FM
MPA
P
L
G
H
ATGFLH
G
VT
AP
-----
FL
I
GA
R
S
VL
LDIF
TP
D
AC
LA
L
L
E
Q
Q
R
C
T
C
M
LGA
T
P
F
V
-
Y
D
L
L
N
L
L
E--
K
QP
A
D
L
SA
L
R
F
F
L
C
GG
TT
IP
KKV-
AR
E
C
Q
Q
R
G
I
K
LL
S
VYG
S
TE
SSP
HA
V
VN
---
LDDP
LP
R
----
F
M
HT
D
GY
AA
-
AGV
E
IK
V
V
DD
ARK
T
LP
P
G
C
E
GE
EAS
R
---
GP
NV
F
M
GYF
DE
P
E
L
TA
R
ALD
E
E
GWY
Y
SGDL
CRM
DE
A
GYI
KIT
GR
K
KD
I
I
V
RGGENIS
SR
E
V
E
D
ILL
Q
HPKI
H
DA
C
VV
A
M
P
DE
RL
GE
R
SCAYVVLK
A
P
H
HS
LS
L
EEV
V
A
F
FS
RK
R
V
AK
Y
K
Y
P
EH
I
V
VI
E
K
LPRT
V
SGKI
Q
K
F
L
LR
KDIMR
RLTQDVCEEIE
fig|749546.3.peg.4514
Escherichia coli MS 185-1
MKVTLTFNEQRRAAYR
QQ
G
L
W
G
D
AS
LAD
YW
-
QQ
TA
R
A
MP
D
K
IAVVD
NH
G
AT
Y
T
Y
S
A
L
DH
AA
S
C
LAN
WMLAK
GI
E
S
GD
RI
A
F
QL
P
G
WC
EF
TVI
Y
L
A
C
LK
T
GA
VS
VP
L
L
P
S
WR
E
A
EL
V
W
V
L
NKC
QA
KMFFAP
T
----
LFK
Q
T
R
P
VD
LI
LPL
Q
NQ
L
P
QL
QQ
I
VGV
D
KLAP
A
T
SS
L
-
S
LS
Q
I
L
A
D
----------
N
T
P
L
T
--
TA
I
T
THG
DE
L
A
AV
LFTSGT
E
G
L
PKGV
ML
THNN
ILA
S
E
R
A
Y
CAR
L
N
LT
W
QDV
FM
MPA
P
L
G
H
ATGFLH
G
VT
AP
-----
FL
I
GA
R
S
VL
LDIF
TP
D
AC
LA
L
L
E
Q
Q
R
C
T
C
M
LGA
T
P
F
V
-
Y
D
L
L
N
L
L
E--
K
QP
A
D
L
SA
L
R
F
F
L
C
GG
TT
IP
KKV-
AR
E
C
Q
Q
R
G
I
K
LL
S
VYG
S
TE
SSP
HA
V
VN
---
LDDP
LP
R
----
F
M
HT
D
GY
AA
-
AGV
E
IK
V
V
DD
ARK
T
LP
P
G
C
E
GE
EAS
R
---
GP
NV
F
M
GYF
DE
P
E
L
TA
R
ALD
E
E
GWY
Y
SGDL
CRM
DE
A
GYI
KIT
GR
K
KD
I
I
V
RGGENIS
SR
E
V
E
D
ILL
Q
HPKI
H
DA
C
VV
A
M
P
DE
RL
GE
R
SCAYVVLK
A
P
H
HS
LS
L
EEV
V
A
F
FS
RK
R
V
AK
Y
K
Y
P
EH
I
V
VI
E
K
LPRT
V
SGKI
Q
K
F
L
LR
KDIMR
RLTQDVCEEIE
fig|749528.3.peg.4834
Escherichia coli MS 45-1
MKVTLTFNEQRRAAYR
QQ
G
L
W
G
D
AS
LAD
YW
-
QQ
TA
R
A
MP
D
K
IAVVD
NH
G
AT
Y
T
Y
S
A
L
DH
AA
S
C
LAN
WMLAK
GI
E
S
GD
RI
A
F
QL
P
G
WC
EF
TVI
Y
L
A
C
LK
T
GA
VS
VP
L
L
P
S
WR
E
A
EL
V
W
V
L
NKC
QA
KMFFAP
T
----
LFK
Q
T
R
P
VD
LI
LPL
Q
NQ
L
P
QL
QQ
I
VGV
D
KLAP
A
T
SS
L
-
S
LS
Q
I
L
A
D
----------
N
T
P
L
T
--
TA
I
T
THG
DE
L
A
AV
LFTSGT
E
G
L
PKGV
ML
THNN
ILA
S
E
R
A
Y
CAR
L
N
LT
W
QDV
FM
MPA
P
L
G
H
ATGFLH
G
VT
AP
-----
FL
I
GA
R
S
VL
LDIF
TP
D
AC
LA
L
L
E
Q
Q
R
C
T
C
M
LGA
T
P
F
V
-
Y
D
L
L
N
L
L
E--
K
QP
A
D
L
SA
L
R
F
F
L
C
GG
TT
IP
KKV-
AR
E
C
Q
Q
R
G
I
K
LL
S
VYG
S
TE
SSP
HA
V
VN
---
LDDP
LP
R
----
F
M
HT
D
GY
AA
-
AGV
E
IK
V
V
DD
ARK
T
LP
P
G
C
E
GE
EAS
R
---
GP
NV
F
M
GYF
DE
P
E
L
TA
R
ALD
E
E
GWY
Y
SGDL
CRM
DE
A
GYI
KIT
GR
K
KD
I
I
V
RGGENIS
SR
E
V
E
D
ILL
Q
HPKI
H
DA
C
VV
A
M
P
DE
RL
GE
R
SCAYVVLK
A
P
H
HS
LS
L
EEV
V
A
F
FS
RK
R
V
AK
Y
K
Y
P
EH
I
V
VI
E
K
LPRT
V
SGKI
Q
K
F
L
LR
KDIMR
RLTQDVCEEIE
fig|585035.6.peg.1742
Escherichia coli S88
MKVTLTFNEQRRAAYR
QQ
G
L
W
G
D
AS
LAD
YW
-
QQ
TA
R
A
MP
D
K
IAVVD
NH
G
AT
Y
T
Y
S
A
L
DH
AA
S
C
LAN
WMLAK
GI
E
S
GD
RI
A
F
QL
P
G
WC
EF
TVI
Y
L
A
C
LK
T
GA
VS
VP
L
L
P
S
WR
E
A
EL
V
W
V
L
NKC
QA
KMFFAP
T
----
LFK
Q
T
R
P
VD
LI
LPL
Q
NQ
L
P
QL
QQ
I
VGV
D
KLAP
A
T
SS
L
-
S
LS
Q
I
L
A
D
----------
N
T
P
L
T
--
TA
I
T
THG
DE
L
A
AV
LFTSGT
E
G
L
PKGV
ML
THNN
ILA
S
E
R
A
Y
CAR
L
N
LT
W
QDV
FM
MPA
P
L
G
H
ATGFLH
G
VT
AP
-----
FL
I
GA
R
S
VL
LDIF
TP
D
AC
LA
L
L
E
Q
Q
R
C
T
C
M
LGA
T
P
F
V
-
Y
D
L
L
N
L
L
E--
K
QP
A
D
L
SA
L
R
F
F
L
C
GG
TT
IP
KKV-
AR
E
C
Q
Q
R
G
I
K
LL
S
VYG
S
TE
SSP
HA
V
VN
---
LDDP
LP
R
----
F
M
HT
D
GY
AA
-
AGV
E
IK
V
V
DD
ARK
T
LP
P
G
C
E
GE
EAS
R
---
GP
NV
F
M
GYF
DE
P
E
L
TA
R
ALD
E
E
GWY
Y
SGDL
CRM
DE
A
GYI
KIT
GR
K
KD
I
I
V
RGGENIS
SR
E
V
E
D
ILL
Q
HPKI
H
DA
C
VV
A
M
P
DE
RL
GE
R
SCAYVVLK
A
P
H
HS
LS
L
EEV
V
A
F
FS
RK
R
V
AK
Y
K
Y
P
EH
I
V
VI
E
K
LPRT
V
SGKI
Q
K
F
L
LR
KDIMR
RLTQDVCEEIE
fig|431946.3.peg.1622
Escherichia coli SE15
MKVTLTFNEQRRAAYR
QQ
G
L
W
G
D
AS
LAD
YW
-
QQ
TA
R
A
MP
D
K
IAVVD
NH
G
AT
Y
T
Y
S
A
L
DH
AA
S
C
LAN
WMLAK
GI
E
S
GD
RI
A
F
QL
P
G
WC
EF
TVI
Y
L
A
C
LK
T
GA
VS
VP
L
L
P
S
WR
E
A
EL
V
W
V
L
NKC
QA
KMFFAP
T
----
LFK
Q
T
R
P
VD
LI
LPL
Q
NQ
L
P
QL
QQ
I
VGV
D
KLAP
A
T
SS
L
-
S
LS
Q
I
L
A
D
----------
N
T
P
L
T
--
TA
I
T
THG
DE
L
A
AV
LFTSGT
E
G
L
PKGV
ML
THNN
ILA
S
E
R
A
Y
CAR
L
N
LT
W
QDV
FM
MPA
P
L
G
H
ATGFLH
G
VT
AP
-----
FL
I
GA
R
S
VL
LDIF
TP
D
AC
LA
L
L
E
Q
Q
R
C
T
C
M
LGA
T
P
F
V
-
Y
D
L
L
N
L
L
E--
K
QP
A
D
L
SA
L
R
F
F
L
C
GG
TT
IP
KKV-
AR
E
C
Q
Q
R
G
I
K
LL
S
VYG
S
TE
SSP
HA
V
VN
---
LDDP
LP
R
----
F
M
HT
D
GY
AA
-
AGV
E
IK
V
V
DD
ARK
T
LP
P
G
C
E
GE
EAS
R
---
GP
NV
F
M
GYF
DE
P
E
L
TA
R
ALD
E
E
GWY
Y
SGDL
CRM
DE
A
GYI
KIT
GR
K
KD
I
I
V
RGGENIS
SR
E
V
E
D
ILL
Q
HPKI
H
DA
C
VV
A
M
P
DE
RL
GE
R
SCAYVVLK
A
P
H
HS
LS
L
EEV
V
A
F
FS
RK
R
V
AK
Y
K
Y
P
EH
I
V
VI
E
K
LPRT
V
SGKI
Q
K
F
L
LR
KDIMR
RLTQDVCEEIE
fig|869729.3.peg.1834
Escherichia coli UM146
MKVTLTFNEQRRAAYR
QQ
G
L
W
G
D
AS
LAD
YW
-
QQ
TA
R
A
MP
D
K
IAVVD
NH
G
AT
Y
T
Y
S
A
L
DH
AA
S
C
LAN
WMLAK
GI
E
S
GD
RI
A
F
QL
P
G
WC
EF
TVI
Y
L
A
C
LK
T
GA
VS
VP
L
L
P
S
WR
E
A
EL
V
W
V
L
NKC
QA
KMFFAP
T
----
LFK
Q
T
R
P
VD
LI
LPL
Q
NQ
L
P
QL
QQ
I
VGV
D
KLAP
A
T
SS
L
-
S
LS
Q
I
L
A
D
----------
N
T
P
L
T
--
TA
I
T
THG
DE
L
A
AV
LFTSGT
E
G
L
PKGV
ML
THNN
ILA
S
E
R
A
Y
CAR
L
N
LT
W
QDV
FM
MPA
P
L
G
H
ATGFLH
G
VT
AP
-----
FL
I
GA
R
S
VL
LDIF
TP
D
AC
LA
L
L
E
Q
Q
R
C
T
C
M
LGA
T
P
F
V
-
Y
D
L
L
N
L
L
E--
K
QP
A
D
L
SA
L
R
F
F
L
C
GG
TT
IP
KKV-
AR
E
C
Q
Q
R
G
I
K
LL
S
VYG
S
TE
SSP
HA
V
VN
---
LDDP
LP
R
----
F
M
HT
D
GY
AA
-
AGV
E
IK
V
V
DD
ARK
T
LP
P
G
C
E
GE
EAS
R
---
GP
NV
F
M
GYF
DE
P
E
L
TA
R
ALD
E
E
GWY
Y
SGDL
CRM
DE
A
GYI
KIT
GR
K
KD
I
I
V
RGGENIS
SR
E
V
E
D
ILL
Q
HPKI
H
DA
C
VV
A
M
P
DE
RL
GE
R
SCAYVVLK
A
P
H
HS
LS
L
EEV
V
A
F
FS
RK
R
V
AK
Y
K
Y
P
EH
I
V
VI
E
K
LPRT
V
SGKI
Q
K
F
L
LR
KDIMR
RLTQDVCEEIE
fig|562.376.peg.2419
Escherichia coli WV_060327
MKVTLTFNEQRRAAYR
QQ
G
L
W
G
D
AS
LAD
YW
-
QQ
TA
R
A
MP
D
K
IAVVD
NH
G
AT
Y
T
Y
S
A
L
DH
AA
S
C
LAN
WMLAK
GI
E
S
GD
RI
A
F
QL
P
G
WC
EF
TVI
Y
L
A
C
LK
T
GA
VS
VP
L
L
P
S
WR
E
A
EL
V
W
V
L
NKC
QA
KMFFAP
T
----
LFK
Q
T
R
P
VD
LI
LPL
Q
NQ
L
P
QL
QQ
I
VGV
D
KLAP
A
T
SS
L
-
S
LS
Q
I
L
A
D
----------
N
T
P
L
T
--
TA
I
T
THG
DE
L
A
AV
LFTSGT
E
G
L
PKGV
ML
THNN
ILA
S
E
R
A
Y
CAR
L
N
LT
W
QDV
FM
MPA
P
L
G
H
ATGFLH
G
VT
AP
-----
FL
I
GA
R
S
VL
LDIF
TP
D
AC
LA
L
L
E
Q
Q
R
C
T
C
M
LGA
T
P
F
V
-
Y
D
L
L
N
L
L
E--
K
QP
A
D
L
SA
L
R
F
F
L
C
GG
TT
IP
KKV-
AR
E
C
Q
Q
R
G
I
K
LL
S
VYG
S
TE
SSP
HA
V
VN
---
LDDP
LP
R
----
F
M
HT
D
GY
AA
-
AGV
E
IK
V
V
DD
ARK
T
LP
P
G
C
E
GE
EAS
R
---
GP
NV
F
M
GYF
DE
P
E
L
TA
R
ALD
E
E
GWY
Y
SGDL
CRM
DE
A
GYI
KIT
GR
K
KD
I
I
V
RGGENIS
SR
E
V
E
D
ILL
Q
HPKI
H
DA
C
VV
A
M
P
DE
RL
GE
R
SCAYVVLK
A
P
H
HS
LS
L
EEV
V
A
F
FS
RK
R
V
AK
Y
K
Y
P
EH
I
V
VI
E
K
LPRT
V
SGKI
Q
K
F
L
LR
KDIMR
RLTQDVCEEIE
fig|405955.9.peg.1461
Escherichia coli APEC O1 (19-566/566)
MKVTLTFNEQRRAAYR
QQ
G
L
W
G
D
AS
LAD
YW
-
QQ
TA
R
A
MP
D
K
IAVVD
NH
G
AT
Y
T
Y
S
A
L
DH
AA
S
C
LAN
WMLAK
GI
E
S
GD
RI
A
F
QL
P
G
WC
EF
TVI
Y
L
A
C
LK
T
GA
VS
VP
L
L
P
S
WR
E
A
EL
V
W
V
L
NKC
QA
KMFFAP
T
----
LFK
Q
T
R
P
VD
LI
LPL
Q
NQ
L
P
QL
QQ
I
VGV
D
KLAP
A
T
SS
L
-
S
LS
Q
I
L
A
D
----------
N
T
P
L
T
--
TA
I
T
THG
DE
L
A
AV
LFTSGT
E
G
L
PKGV
ML
THNN
ILA
S
E
R
A
Y
CAR
L
N
LT
W
QDV
FM
MPA
P
L
G
H
ATGFLH
G
VT
AP
-----
FL
I
GA
R
S
VL
LDIF
TP
D
AC
LA
L
L
E
Q
Q
R
C
T
C
M
LGA
T
P
F
V
-
Y
D
L
L
N
L
L
E--
K
QP
A
D
L
SA
L
R
F
F
L
C
GG
TT
IP
KKV-
AR
E
C
Q
Q
R
G
I
K
LL
S
VYG
S
TE
SSP
HA
V
VN
---
LDDP
LP
R
----
F
M
HT
D
GY
AA
-
AGV
E
IK
V
V
DD
ARK
T
LP
P
G
C
E
GE
EAS
R
---
GP
NV
F
M
GYF
DE
P
E
L
TA
R
ALD
E
E
GWY
Y
SGDL
CRM
DE
A
GYI
KIT
GR
K
KD
I
I
V
RGGENIS
SR
E
V
E
D
ILL
Q
HPKI
H
DA
C
VV
A
M
P
DE
RL
GE
R
SCAYVVLK
A
P
H
HS
LS
L
EEV
V
A
F
FS
RK
R
V
AK
Y
K
Y
P
EH
I
V
VI
E
K
LPRT
V
SGKI
Q
K
F
L
LR
KDIMR
RLTQDVCEEIE
fig|199310.1.peg.2035
Escherichia coli CFT073 (19-566/566)
MKVTLTFNEQRRAAYR
QQ
G
L
W
G
D
AS
LAD
YW
-
QQ
TA
R
A
MP
D
K
IAVVD
NH
G
AT
Y
T
Y
S
A
L
DH
AA
S
C
LAN
WMLAK
GI
E
S
GD
RI
A
F
QL
P
G
WC
EF
TVI
Y
L
A
C
LK
T
GA
VS
VP
L
L
P
S
WR
E
A
EL
V
W
V
L
NKC
QA
KMFFAP
T
----
LFK
Q
T
R
P
VD
LI
LPL
Q
NQ
L
P
QL
QQ
I
VGV
D
KLAP
A
T
SS
L
-
S
LS
Q
I
L
A
D
----------
N
T
P
L
T
--
TA
I
T
THG
DE
L
A
AV
LFTSGT
E
G
L
PKGV
ML
THNN
ILA
S
E
R
A
Y
CAR
L
N
LT
W
QDV
FM
MPA
P
L
G
H
ATGFLH
G
VT
AP
-----
FL
I
GA
R
S
VL
LDIF
TP
D
AC
LA
L
L
E
Q
Q
R
C
T
C
M
LGA
T
P
F
V
-
Y
D
L
L
N
L
L
E--
K
QP
A
D
L
SA
L
R
F
F
L
C
GG
TT
IP
KKV-
AR
E
C
Q
Q
R
G
I
K
LL
S
VYG
S
TE
SSP
HA
V
VN
---
LDDP
LP
R
----
F
M
HT
D
GY
AA
-
AGV
E
IK
V
V
DD
ARK
T
LP
P
G
C
E
GE
EAS
R
---
GP
NV
F
M
GYF
DE
P
E
L
TA
R
ALD
E
E
GWY
Y
SGDL
CRM
DE
A
GYI
KIT
GR
K
KD
I
I
V
RGGENIS
SR
E
V
E
D
ILL
Q
HPKI
H
DA
C
VV
A
M
P
DE
RL
GE
R
SCAYVVLK
A
P
H
HS
LS
L
EEV
V
A
F
FS
RK
R
V
AK
Y
K
Y
P
EH
I
V
VI
E
K
LPRT
V
SGKI
Q
K
F
L
LR
KDIMR
RLTQDVCEEIE
fig|566546.3.peg.942
Escherichia coli W
MKVTLTFNEQRRAAYR
QQ
G
L
W
G
D
AS
LAD
YW
-
QQ
TA
R
A
MP
D
K
IAVVD
NH
G
AS
Y
N
Y
S
A
L
DH
AA
S
C
LAN
WMLAK
GI
E
S
GD
RI
A
F
QL
P
G
WC
EF
TVI
Y
L
A
C
LKIGA
VS
VP
L
L
P
S
WR
E
A
EL
V
W
V
L
NKC
QA
KMFFAP
T
----
LFK
Q
T
R
P
VD
LI
LPL
Q
NQ
L
P
QL
QQ
I
VGV
D
KLAP
A
T
SS
L
-
S
LS
Q
I
I
A
D
----------
N
T
P
L
T
--
TA
I
T
THG
DE
L
A
AV
LFTSGT
E
G
L
PKGV
ML
THNN
ILA
S
E
R
A
Y
CAR
L
N
LT
W
QDV
FM
MPA
P
L
G
H
ATGFLH
G
VT
AP
-----
FL
I
GA
R
S
VL
LDIF
TP
D
AC
LA
L
L
E
Q
Q
R
C
T
C
M
LGA
T
P
F
V
-
Y
D
L
L
N
L
L
E--
K
QP
A
D
L
SA
L
R
F
F
L
C
GG
TT
IP
KKV-
AR
E
C
Q
Q
R
G
I
K
LL
S
VYG
S
TE
SSP
HA
V
VN
---
LDDP
LS
R
----
F
M
HT
D
GY
AA
-
AGV
E
IK
V
V
DD
ARK
T
LP
P
G
C
E
GE
EAS
R
---
GP
NV
F
M
GYF
DE
P
E
L
TA
R
ALD
E
E
GWY
Y
SGDL
CRM
DE
A
GYI
KIT
GR
K
KD
I
I
V
RGGENIS
SR
E
V
E
D
ILL
Q
HPKI
H
DA
C
VV
A
M
P
DE
RL
GE
R
SCAYVVLK
A
P
H
HS
LS
L
EEV
V
A
F
FS
RK
R
V
-
K
Y
K
Y
P
EH
I
V
VI
E
K
LPRT
A
SGKI
Q
K
F
L
LR
KDIMR
RLTQDVCEEIE
fig|566546.4.peg.1857
Escherichia coli W
MKVTLTFNEQRRAAYR
QQ
G
L
W
G
D
AS
LAD
YW
-
QQ
TA
R
A
MP
D
K
IAVVD
NH
G
AS
Y
N
Y
S
A
L
DH
AA
S
C
LAN
WMLAK
GI
E
S
GD
RI
A
F
QL
P
G
WC
EF
TVI
Y
L
A
C
LKIGA
VS
VP
L
L
P
S
WR
E
A
EL
V
W
V
L
NKC
QA
KMFFAP
T
----
LFK
Q
T
R
P
VD
LI
LPL
Q
NQ
L
P
QL
QQ
I
VGV
D
KLAP
A
T
SS
L
-
S
LS
Q
I
I
A
D
----------
N
T
P
L
T
--
TA
I
T
THG
DE
L
A
AV
LFTSGT
E
G
L
PKGV
ML
THNN
ILA
S
E
R
A
Y
CAR
L
N
LT
W
QDV
FM
MPA
P
L
G
H
ATGFLH
G
VT
AP
-----
FL
I
GA
R
S
VL
LDIF
TP
D
AC
LA
L
L
E
Q
Q
R
C
T
C
M
LGA
T
P
F
V
-
Y
D
L
L
N
L
L
E--
K
QP
A
D
L
SA
L
R
F
F
L
C
GG
TT
IP
KKV-
AR
E
C
Q
Q
R
G
I
K
LL
S
VYG
S
TE
SSP
HA
V
VN
---
LDDP
LS
R
----
F
M
HT
D
GY
AA
-
AGV
E
IK
V
V
DD
ARK
T
LP
P
G
C
E
GE
EAS
R
---
GP
NV
F
M
GYF
DE
P
E
L
TA
R
ALD
E
E
GWY
Y
SGDL
CRM
DE
A
GYI
KIT
GR
K
KD
I
I
V
RGGENIS
SR
E
V
E
D
ILL
Q
HPKI
H
DA
C
VV
A
M
P
DE
RL
GE
R
SCAYVVLK
A
P
H
HS
LS
L
EEV
V
A
F
FS
RK
R
V
-
K
Y
K
Y
P
EH
I
V
VI
E
K
LPRT
A
SGKI
Q
K
F
L
LR
KDIMR
RLTQDVCEEIE
fig|216593.1.peg.478
Escherichia coli E2348/69 (19-566/566)
MKVTLTFNEQRRAAYR
QQ
G
L
W
G
D
AS
LAD
YW
-
QQ
TA
R
A
MP
D
K
IAVVD
NH
G
AT
Y
T
Y
S
A
L
DH
AA
S
C
LAN
WMLAK
GI
E
S
GD
RI
A
F
QL
P
G
WC
EF
TVI
Y
L
A
C
LK
T
GA
VS
VP
L
L
P
S
WR
E
A
EL
V
W
V
L
NKC
QA
KMFFAP
T
----
LFK
Q
T
R
P
VD
LI
LPL
Q
NQ
L
P
QL
QQ
I
VGV
D
KLSP
A
T
SS
L
-
S
LS
Q
I
L
A
D
----------
N
T
P
L
T
--
TA
I
T
THG
DE
L
A
AV
LFTSGT
E
G
L
PKGV
ML
THNN
ILA
S
E
R
A
Y
CAR
L
N
LT
W
QDV
FM
MPA
P
L
G
H
ATGFLH
G
VT
AP
-----
FL
I
GA
R
S
VL
LDIF
TP
D
AC
LA
L
L
E
Q
Q
R
C
T
C
M
LGA
T
P
F
V
-
Y
D
L
L
N
L
L
E--
K
QP
A
D
L
SA
L
R
F
F
L
C
GG
TT
IP
KKV-
AR
E
C
Q
Q
R
G
I
K
LL
S
VYG
S
TE
SSP
HA
V
VN
---
LDDP
LP
R
----
F
M
HT
D
GY
AA
-
AGV
E
IK
V
V
DD
ARK
T
LP
P
G
C
E
GE
EAS
R
---
GP
NV
F
M
GYF
DE
P
E
L
TA
R
ALD
E
E
GWY
Y
SGDL
CRM
DE
A
GYI
KIT
GR
K
KD
I
I
V
RGGENIS
SR
E
V
E
D
ILL
Q
HPKI
H
DA
C
VV
A
M
P
DE
RL
GE
R
SCAYVVLK
A
P
H
HS
LS
L
EEV
V
A
F
FS
RK
R
V
AK
Y
K
Y
P
EH
I
V
VI
E
K
LPRT
V
SGKI
Q
K
F
L
LR
KDIMR
RLTQDVCEEIE
fig|656379.3.peg.2174
Escherichia coli FVEC1302
MKVTLTFNEQRRAAYR
QQ
G
L
W
G
D
AS
LAD
YW
-
QQ
TA
R
A
MP
D
K
IAVVD
NH
G
AS
Y
T
Y
S
A
L
DH
AA
S
C
LAN
WMLAK
GI
E
S
GD
RI
A
F
QL
P
G
WC
EF
TVI
Y
L
A
C
LKIGA
VS
VP
L
L
P
S
WR
E
A
EL
V
W
V
L
NKC
QA
KMFFAP
T
----
LFK
Q
T
R
P
VD
LI
LPL
Q
NQ
L
P
QL
QQ
L
VGV
D
KLAP
A
T
S
AL
-
S
LS
Q
I
I
A
D
----------
N
T
P
L
T
--
TA
I
T
VHG
DE
L
A
AV
LFTSGT
E
G
L
PKGV
ML
THNN
ILA
S
E
R
A
Y
CAR
L
N
LT
W
QDV
FM
MPA
P
L
G
H
ATGFLH
G
VT
AP
-----
FL
I
GA
R
S
VL
LDIF
TP
D
AC
LA
L
L
E
Q
Q
R
C
T
C
M
LGA
T
P
F
V
-
Y
D
L
L
N
L
L
E--
K
QP
A
D
L
SA
L
R
F
F
L
C
GG
TT
IP
KKV-
AR
E
C
Q
Q
R
G
I
K
LL
S
VYG
S
TE
SSP
HA
V
VN
---
LDDP
LS
R
----
F
M
HT
D
GY
AA
-
AGV
E
IK
V
V
DD
ARK
T
LP
P
G
C
E
GE
EAS
R
---
GP
NV
F
M
GYF
DE
P
E
L
TA
R
ALD
E
E
GWY
Y
SGDL
CCM
DE
A
GYI
KIT
GR
K
KD
I
I
V
RGGENIS
SR
E
V
E
D
ILL
Q
HPKI
H
DA
C
VV
A
M
P
DE
RL
GE
R
SCAYVVLK
A
P
H
HS
LS
L
EEV
V
A
F
FS
RK
R
V
AK
Y
K
Y
P
EH
I
V
VI
E
K
LPRT
A
SGKI
Q
K
F
L
LR
KDIMR
RLTQDVCEEIE
fig|656380.3.peg.3138
Escherichia coli FVEC1412
MKVTLTFNEQRRAAYR
QQ
G
L
W
G
D
AS
LAD
YW
-
QQ
TA
R
A
MP
D
K
IAVVD
NH
G
AS
Y
T
Y
S
A
L
DH
AA
S
C
LAN
WMLAK
GI
E
S
GD
RI
A
F
QL
P
G
WC
EF
TVI
Y
L
A
C
LKIGA
VS
VP
L
L
P
S
WR
E
A
EL
V
W
V
L
NKC
QA
KMFFAP
T
----
LFK
Q
T
R
P
VD
LI
LPL
Q
NQ
L
P
QL
QQ
L
VGV
D
KLAP
A
T
S
AL
-
S
LS
Q
I
I
A
D
----------
N
T
P
L
T
--
TA
I
T
VHG
DE
L
A
AV
LFTSGT
E
G
L
PKGV
ML
THNN
ILA
S
E
R
A
Y
CAR
L
N
LT
W
QDV
FM
MPA
P
L
G
H
ATGFLH
G
VT
AP
-----
FL
I
GA
R
S
VL
LDIF
TP
D
AC
LA
L
L
E
Q
Q
R
C
T
C
M
LGA
T
P
F
V
-
Y
D
L
L
N
L
L
E--
K
QP
A
D
L
SA
L
R
F
F
L
C
GG
TT
IP
KKV-
AR
E
C
Q
Q
R
G
I
K
LL
S
VYG
S
TE
SSP
HA
V
VN
---
LDDP
LS
R
----
F
M
HT
D
GY
AA
-
AGV
E
IK
V
V
DD
ARK
T
LP
P
G
C
E
GE
EAS
R
---
GP
NV
F
M
GYF
DE
P
E
L
TA
R
ALD
E
E
GWY
Y
SGDL
CCM
DE
A
GYI
KIT
GR
K
KD
I
I
V
RGGENIS
SR
E
V
E
D
ILL
Q
HPKI
H
DA
C
VV
A
M
P
DE
RL
GE
R
SCAYVVLK
A
P
H
HS
LS
L
EEV
V
A
F
FS
RK
R
V
AK
Y
K
Y
P
EH
I
V
VI
E
K
LPRT
A
SGKI
Q
K
F
L
LR
KDIMR
RLTQDVCEEIE
fig|749549.3.peg.2522
Escherichia coli MS 198-1
MKVTLTFNEQRRAAYR
QQ
G
L
W
G
D
AS
LAD
YW
-
QQ
TA
R
A
MP
D
K
IAVVD
NH
G
AS
Y
T
Y
S
A
L
DH
AA
S
C
LAN
WMLAK
GI
E
S
GD
RI
A
F
QL
P
G
WC
EF
TVI
Y
L
A
C
LKIGA
VS
VP
L
L
P
S
WR
E
A
EL
V
W
V
L
NKC
QA
KMFFAP
T
----
LFK
Q
T
R
P
VD
LI
LPL
Q
NQ
L
P
QL
QQ
L
VGV
D
KLAP
A
T
S
AL
-
S
LS
Q
I
I
A
D
----------
N
T
P
L
T
--
TA
I
T
VHG
DE
L
A
AV
LFTSGT
E
G
L
PKGV
ML
THNN
ILA
S
E
R
A
Y
CAR
L
N
LT
W
QDV
FM
MPA
P
L
G
H
ATGFLH
G
VT
AP
-----
FL
I
GA
R
S
VL
LDIF
TP
D
AC
LA
L
L
E
Q
Q
R
C
T
C
M
LGA
T
P
F
V
-
Y
D
L
L
N
L
L
E--
K
QP
A
D
L
SA
L
R
F
F
L
C
GG
TT
IP
KKV-
AR
E
C
Q
Q
R
G
I
K
LL
S
VYG
S
TE
SSP
HA
V
VN
---
LDDP
LS
R
----
F
M
HT
D
GY
AA
-
AGV
E
IK
V
V
DD
ARK
T
LP
P
G
C
E
GE
EAS
R
---
GP
NV
F
M
GYF
DE
P
E
L
TA
R
ALD
E
E
GWY
Y
SGDL
CCM
DE
A
GYI
KIT
GR
K
KD
I
I
V
RGGENIS
SR
E
V
E
D
ILL
Q
HPKI
H
DA
C
VV
A
M
P
DE
RL
GE
R
SCAYVVLK
A
P
H
HS
LS
L
EEV
V
A
F
FS
RK
R
V
AK
Y
K
Y
P
EH
I
V
VI
E
K
LPRT
A
SGKI
Q
K
F
L
LR
KDIMR
RLTQDVCEEIE
fig|574521.7.peg.1829
Escherichia coli O127:H6 str. E2348/69 (19-566/566)
MKVTLTFNEQRRAAYR
QQ
G
L
W
G
D
AS
LAD
YW
-
QQ
TA
R
A
MP
D
K
IAVVD
NH
G
AT
Y
T
Y
S
A
L
DH
AA
S
C
LAN
WMLAK
GI
E
S
GD
RI
A
F
QL
P
G
WC
EF
TVI
Y
L
A
C
LK
T
GA
VS
VP
L
L
P
S
WR
E
A
EL
V
W
V
L
NKC
QA
KMFFAP
T
----
LFK
Q
T
R
P
VD
LI
LPL
Q
NQ
L
P
QL
QQ
I
VGV
D
KLSP
A
T
SS
L
-
S
LS
Q
I
L
A
D
----------
N
T
P
L
T
--
TA
I
T
THG
DE
L
A
AV
LFTSGT
E
G
L
PKGV
ML
THNN
ILA
S
E
R
A
Y
CAR
L
N
LT
W
QDV
FM
MPA
P
L
G
H
ATGFLH
G
VT
AP
-----
FL
I
GA
R
S
VL
LDIF
TP
D
AC
LA
L
L
E
Q
Q
R
C
T
C
M
LGA
T
P
F
V
-
Y
D
L
L
N
L
L
E--
K
QP
A
D
L
SA
L
R
F
F
L
C
GG
TT
IP
KKV-
AR
E
C
Q
Q
R
G
I
K
LL
S
VYG
S
TE
SSP
HA
V
VN
---
LDDP
LP
R
----
F
M
HT
D
GY
AA
-
AGV
E
IK
V
V
DD
ARK
T
LP
P
G
C
E
GE
EAS
R
---
GP
NV
F
M
GYF
DE
P
E
L
TA
R
ALD
E
E
GWY
Y
SGDL
CRM
DE
A
GYI
KIT
GR
K
KD
I
I
V
RGGENIS
SR
E
V
E
D
ILL
Q
HPKI
H
DA
C
VV
A
M
P
DE
RL
GE
R
SCAYVVLK
A
P
H
HS
LS
L
EEV
V
A
F
FS
RK
R
V
AK
Y
K
Y
P
EH
I
V
VI
E
K
LPRT
V
SGKI
Q
K
F
L
LR
KDIMR
RLTQDVCEEIE
fig|585056.7.peg.2177
Escherichia coli UMN026
MKVTLTFNEQRRAAYR
QQ
G
L
W
G
D
AS
LAD
YW
-
QQ
TA
R
A
MP
D
K
IAVVD
NH
G
AS
Y
T
Y
S
A
L
DH
AA
S
C
LAN
WMLAK
GI
E
S
GD
RI
A
F
QL
P
G
WC
EF
TVI
Y
L
A
C
LKIGA
VS
VP
L
L
P
S
WR
E
A
EL
V
W
V
L
NKC
QA
KMFFAP
T
----
LFK
Q
T
R
P
VD
LI
LPL
Q
NQ
L
P
QL
QQ
L
VGV
D
KLAP
A
T
S
AL
-
S
LS
Q
I
I
A
D
----------
N
T
P
L
T
--
TA
I
T
VHG
DE
L
A
AV
LFTSGT
E
G
L
PKGV
ML
THNN
ILA
S
E
R
A
Y
CAR
L
N
LT
W
QDV
FM
MPA
P
L
G
H
ATGFLH
G
VT
AP
-----
FL
I
GA
R
S
VL
LDIF
TP
D
AC
LA
L
L
E
Q
Q
R
C
T
C
M
LGA
T
P
F
V
-
Y
D
L
L
N
L
L
E--
K
QP
A
D
L
SA
L
R
F
F
L
C
GG
TT
IP
KKV-
AR
E
C
Q
Q
R
G
I
K
LL
S
VYG
S
TE
SSP
HA
V
VN
---
LDDP
LS
R
----
F
M
HT
D
GY
AA
-
AGV
E
IK
V
V
DD
ARK
T
LP
P
G
C
E
GE
EAS
R
---
GP
NV
F
M
GYF
DE
P
E
L
TA
R
ALD
E
E
GWY
Y
SGDL
CCM
DE
A
GYI
KIT
GR
K
KD
I
I
V
RGGENIS
SR
E
V
E
D
ILL
Q
HPKI
H
DA
C
VV
A
M
P
DE
RL
GE
R
SCAYVVLK
A
P
H
HS
LS
L
EEV
V
A
F
FS
RK
R
V
AK
Y
K
Y
P
EH
I
V
VI
E
K
LPRT
A
SGKI
Q
K
F
L
LR
KDIMR
RLTQDVCEEIE
fig|656417.3.peg.2203
Escherichia coli M605
MKVTLTFNEQRRAAYR
QQ
G
L
W
G
D
AS
LAD
YW
-
QQ
TA
R
A
MP
D
K
IAVVD
NH
G
AT
Y
T
Y
S
A
L
DH
AA
S
C
LAN
WMLAK
GI
E
S
GD
RI
A
F
QL
P
G
WC
EF
TVI
Y
L
A
C
LK
T
GA
VS
VP
L
L
P
S
WR
E
A
EL
V
W
V
L
NKC
QA
KMFFAP
T
----
LFK
Q
T
R
P
VD
LI
LPL
Q
NQ
L
P
QL
QQ
I
VGV
D
KLAP
A
T
SS
L
-
S
LS
Q
I
L
A
D
----------
N
T
P
L
T
--
TA
I
T
THG
DE
L
A
AV
LFTSGT
E
G
L
PKGV
ML
THNN
ILA
S
E
R
A
Y
CAR
L
N
LT
W
QDV
FM
MPA
P
L
G
H
ATGFLH
G
VT
AP
-----
FL
I
GA
R
S
VL
LDIF
TP
D
AC
LA
L
L
E
Q
Q
R
C
T
C
M
LGA
T
P
F
V
-
Y
D
L
L
N
L
L
E--
K
QP
A
D
L
SA
L
R
F
F
L
C
GG
TT
IP
KKV-
AR
E
C
Q
Q
R
G
I
K
LL
S
VYG
S
TE
SSP
HA
V
VN
---
LDDP
LP
R
----
F
M
HT
D
GY
AA
-
AGV
E
IK
V
V
DD
ARK
T
LP
P
G
C
E
GE
EAS
R
---
GP
NV
F
M
GYF
DE
P
E
L
TA
R
ALD
E
E
GWY
Y
SGDL
CRM
DE
A
GYI
KIT
GR
K
KD
I
I
V
RGGENIS
SR
E
V
E
D
ILL
Q
HPKI
H
DA
C
VV
A
M
P
DE
RL
GE
R
SCAYVVLK
A
P
H
HS
LS
L
EEV
V
A
F
FS
RK
R
V
AK
Y
K
Y
P
EH
I
V
VI
E
K
LPRT
V
SGKI
Q
K
F
L
LR
E
DIMR
RLTQDVCEEIE
fig|340185.4.peg.3828
Escherichia coli E22
MKVTLTFNEQRRAAYR
QQ
G
L
W
G
D
AS
LAD
YW
-
QQ
TA
R
A
MP
D
K
IAVVD
NH
G
AS
Y
T
Y
S
A
L
DH
AA
S
C
LAN
WMLAK
GI
E
S
GD
RI
A
F
QL
P
G
WC
EF
TVI
Y
L
A
C
LKIGA
VS
VP
L
L
P
S
WR
E
A
EL
V
W
V
L
NKC
QA
KMFFAP
T
----
LFK
Q
T
R
P
VD
LI
LPL
Q
NQ
L
P
QL
QQ
I
VGV
D
KLAP
A
T
SS
L
-
S
LS
Q
I
I
A
D
----------
N
T
S
L
T
--
TA
I
T
THG
DE
L
A
AV
LFTSGT
E
G
L
PKGV
ML
THNN
ILA
S
E
R
A
Y
CVR
L
N
LT
W
QDV
FM
MPA
P
L
G
H
ATGFLH
G
VT
AP
-----
FL
I
GA
R
S
VL
LDIF
TP
D
AC
LA
L
L
E
Q
Q
R
C
T
C
M
LGA
T
P
F
V
-
Y
D
L
L
N
V
L
E--
K
QP
A
D
L
SA
L
R
F
F
L
C
GG
TT
IP
KKV-
AR
E
C
Q
Q
L
G
I
K
LL
S
VYG
S
TE
SSP
HA
V
VN
---
LDDP
LS
R
----
F
M
HT
D
GY
AA
-
AGV
E
IK
V
V
DD
ARK
T
LP
P
G
C
E
GE
EAS
R
---
GP
NV
F
M
GYF
DE
P
E
L
TA
R
ALD
E
E
GWY
Y
SGDL
CRM
DE
A
GYI
KIT
GR
K
KD
I
I
V
RGGENIS
SR
E
V
E
D
ILL
Q
HPKI
H
DA
C
VV
A
M
P
DE
RL
GE
R
SCAYVVLK
A
P
H
HS
LS
L
EEV
V
A
F
FS
RK
R
V
AK
Y
K
Y
P
EH
I
V
VI
E
K
LPRT
A
SGKI
Q
K
F
L
LR
KDIMR
RLTQDVCEEIE
fig|585395.4.peg.1932
Escherichia coli O103:H2 str. 12009
MKVTLTFNEQRRAAYR
QQ
G
L
W
G
D
AS
LAD
YW
-
QQ
TA
R
A
MP
D
K
IAVVD
NH
G
AS
Y
T
Y
S
A
L
DH
AA
S
C
LAN
WMLAK
GI
E
S
GD
RI
A
F
QL
P
G
WC
EF
TVI
Y
L
A
C
LKIGA
VS
VP
L
L
P
S
WR
E
A
EL
V
W
V
L
NKC
QA
KMFFAP
T
----
LFK
Q
T
R
P
VD
LI
LPL
Q
NQ
L
P
QL
QQ
I
VGV
D
KLAP
A
T
SS
L
-
S
LS
Q
I
I
A
D
----------
N
T
S
L
T
--
TA
I
T
THG
DE
L
A
AV
LFTSGT
E
G
L
PKGV
ML
THNN
ILA
S
E
R
A
Y
CVR
L
N
LT
W
QDV
FM
MPA
P
L
G
H
ATGFLH
G
VT
AP
-----
FL
I
GA
R
S
VL
LDIF
TP
D
AC
LA
L
L
E
Q
Q
R
C
T
C
M
LGA
T
P
F
V
-
Y
D
L
L
N
V
L
E--
K
QP
A
D
L
SA
L
R
F
F
L
C
GG
TT
IP
KKV-
AR
E
C
Q
Q
L
G
I
K
LL
S
VYG
S
TE
SSP
HA
V
VN
---
LDDP
LS
R
----
F
M
HT
D
GY
AA
-
AGV
E
IK
V
V
DD
ARK
T
LP
P
G
C
E
GE
EAS
R
---
GP
NV
F
M
GYF
DE
P
E
L
TA
R
ALD
E
E
GWY
Y
SGDL
CRM
DE
A
GYI
KIT
GR
K
KD
I
I
V
RGGENIS
SR
E
V
E
D
ILL
Q
HPKI
H
DA
C
VV
A
M
P
DE
RL
GE
R
SCAYVVLK
A
P
H
HS
LS
L
EEV
V
A
F
FS
RK
R
V
AK
Y
K
Y
P
EH
I
V
VI
E
K
LPRT
A
SGKI
Q
K
F
L
LR
KDIMR
RLTQDVCEEIE
fig|340185.3.peg.3640
Escherichia coli E22 (19-566/566)
MKVTLTFNEQRRAAYR
QQ
G
L
W
G
D
AS
LAD
YW
-
QQ
TA
R
A
MP
D
K
IAVVD
NH
G
AS
Y
T
Y
S
A
L
DH
AA
S
C
LAN
WMLAK
GI
E
S
GD
RI
A
F
QL
P
G
WC
EF
TVI
Y
L
A
C
LKIGA
VS
VP
L
L
P
S
WR
E
A
EL
V
W
V
L
NKC
QA
KMFFAP
T
----
LFK
Q
T
R
P
VD
LI
LPL
Q
NQ
L
P
QL
QQ
I
VGV
D
KLAP
A
T
SS
L
-
S
LS
Q
I
I
A
D
----------
N
T
S
L
T
--
TA
I
T
THG
DE
L
A
AV
LFTSGT
E
G
L
PKGV
ML
THNN
ILA
S
E
R
A
Y
CVR
L
N
LT
W
QDV
FM
MPA
P
L
G
H
ATGFLH
G
VT
AP
-----
FL
I
GA
R
S
VL
LDIF
TP
D
AC
LA
L
L
E
Q
Q
R
C
T
C
M
LGA
T
P
F
V
-
Y
D
L
L
N
V
L
E--
K
QP
A
D
L
SA
L
R
F
F
L
C
GG
TT
IP
KKV-
AR
E
C
Q
Q
L
G
I
K
LL
S
VYG
S
TE
SSP
HA
V
VN
---
LDDP
LS
R
----
F
M
HT
D
GY
AA
-
AGV
E
IK
V
V
DD
ARK
T
LP
P
G
C
E
GE
EAS
R
---
GP
NV
F
M
GYF
DE
P
E
L
TA
R
ALD
E
E
GWY
Y
SGDL
CRM
DE
A
GYI
KIT
GR
K
KD
I
I
V
RGGENIS
SR
E
V
E
D
ILL
Q
HPKI
H
DA
C
VV
A
M
P
DE
RL
GE
R
SCAYVVLK
A
P
H
HS
LS
L
EEV
V
A
F
FS
RK
R
V
AK
Y
K
Y
P
EH
I
V
VI
E
K
LPRT
A
SGKI
Q
K
F
L
LR
KDIMR
RLTQDVCEEIE
fig|362663.8.peg.1663
Escherichia coli 536
MKVTLTFNEQRRAAYR
QQ
G
L
W
G
D
AS
LAD
YW
-
QQ
TA
R
A
MP
D
K
IAVVD
NH
G
AT
Y
T
Y
S
A
L
DH
AA
S
C
LAN
WMLAK
GI
E
S
GD
RI
A
F
QL
P
G
WC
EF
TVI
Y
L
A
C
LK
T
GA
VS
VP
L
L
P
S
WR
E
A
EL
V
W
V
L
NKC
QA
KMFFAP
T
----
LFK
Q
T
R
P
VD
LI
LPL
Q
NQ
L
P
QL
QQ
I
VGV
D
KLAP
A
T
SS
L
-
S
LS
Q
I
L
A
D
----------
N
T
P
L
T
--
TA
I
T
VHG
DE
L
A
AV
LFTSGT
E
G
L
PKGV
ML
THNN
ILA
S
E
R
A
Y
CAR
L
N
LT
W
QDV
FM
MPA
P
L
G
H
ATGFLH
G
VT
AP
-----
FL
I
GA
R
S
VL
LDIF
TP
D
AC
LA
L
L
E
Q
Q
R
C
T
C
M
LGA
T
P
F
V
-
Y
D
L
L
N
L
L
E--
K
QP
A
D
L
SA
L
R
F
F
L
C
GG
TT
IP
KKV-
AR
E
C
Q
Q
R
G
I
K
LL
S
VYG
S
TE
SSP
HA
V
VN
---
LDDP
LP
R
----
F
M
HT
D
GY
AA
-
AGV
E
IK
V
V
DD
ARK
T
LP
P
G
C
E
GE
EAS
R
---
GP
NV
F
M
GYF
DE
P
E
L
TA
R
ALD
E
E
GWY
Y
SGDL
CRM
DE
A
GYI
KIT
GR
K
KD
I
I
V
RGGENIS
SR
E
V
E
D
ILL
Q
HPKI
H
DA
C
VV
A
M
P
DE
RL
GE
R
SCAYVVLK
A
P
H
HS
LS
L
EEV
V
A
F
FS
RK
R
V
AK
Y
K
Y
P
EH
I
V
VI
E
K
LPRT
V
SGKI
Q
K
F
L
LR
KDIMR
RLTQDVCEEIE
fig|362663.9.peg.1667
Escherichia coli 536
MKVTLTFNEQRRAAYR
QQ
G
L
W
G
D
AS
LAD
YW
-
QQ
TA
R
A
MP
D
K
IAVVD
NH
G
AT
Y
T
Y
S
A
L
DH
AA
S
C
LAN
WMLAK
GI
E
S
GD
RI
A
F
QL
P
G
WC
EF
TVI
Y
L
A
C
LK
T
GA
VS
VP
L
L
P
S
WR
E
A
EL
V
W
V
L
NKC
QA
KMFFAP
T
----
LFK
Q
T
R
P
VD
LI
LPL
Q
NQ
L
P
QL
QQ
I
VGV
D
KLAP
A
T
SS
L
-
S
LS
Q
I
L
A
D
----------
N
T
P
L
T
--
TA
I
T
VHG
DE
L
A
AV
LFTSGT
E
G
L
PKGV
ML
THNN
ILA
S
E
R
A
Y
CAR
L
N
LT
W
QDV
FM
MPA
P
L
G
H
ATGFLH
G
VT
AP
-----
FL
I
GA
R
S
VL
LDIF
TP
D
AC
LA
L
L
E
Q
Q
R
C
T
C
M
LGA
T
P
F
V
-
Y
D
L
L
N
L
L
E--
K
QP
A
D
L
SA
L
R
F
F
L
C
GG
TT
IP
KKV-
AR
E
C
Q
Q
R
G
I
K
LL
S
VYG
S
TE
SSP
HA
V
VN
---
LDDP
LP
R
----
F
M
HT
D
GY
AA
-
AGV
E
IK
V
V
DD
ARK
T
LP
P
G
C
E
GE
EAS
R
---
GP
NV
F
M
GYF
DE
P
E
L
TA
R
ALD
E
E
GWY
Y
SGDL
CRM
DE
A
GYI
KIT
GR
K
KD
I
I
V
RGGENIS
SR
E
V
E
D
ILL
Q
HPKI
H
DA
C
VV
A
M
P
DE
RL
GE
R
SCAYVVLK
A
P
H
HS
LS
L
EEV
V
A
F
FS
RK
R
V
AK
Y
K
Y
P
EH
I
V
VI
E
K
LPRT
V
SGKI
Q
K
F
L
LR
KDIMR
RLTQDVCEEIE
fig|340197.5.peg.1941
Escherichia coli F11
MKVTLTFNEQRRAAYR
QQ
G
L
W
G
D
AS
LAD
YW
-
QQ
TA
R
A
MP
D
K
IAVVD
NH
G
AT
Y
T
Y
S
A
L
DH
AA
S
C
LAN
WMLAK
GI
E
S
GD
RI
A
F
QL
P
G
WC
EF
TVI
Y
L
A
C
LK
T
GA
VS
VP
L
L
P
S
WR
E
A
EL
V
W
V
L
NKC
QA
KMFFAP
T
----
LFK
Q
T
R
P
VD
LI
LPL
Q
NQ
L
P
QL
QQ
I
VGV
D
KLAP
A
T
SS
L
-
S
LS
Q
I
L
A
D
----------
N
T
P
L
T
--
TA
I
T
VHG
DE
L
A
AV
LFTSGT
E
G
L
PKGV
ML
THNN
ILA
S
E
R
A
Y
CAR
L
N
LT
W
QDV
FM
MPA
P
L
G
H
ATGFLH
G
VT
AP
-----
FL
I
GA
R
S
VL
LDIF
TP
D
AC
LA
L
L
E
Q
Q
R
C
T
C
M
LGA
T
P
F
V
-
Y
D
L
L
N
L
L
E--
K
QP
A
D
L
SA
L
R
F
F
L
C
GG
TT
IP
KKV-
AR
E
C
Q
Q
R
G
I
K
LL
S
VYG
S
TE
SSP
HA
V
VN
---
LDDP
LP
R
----
F
M
HT
D
GY
AA
-
AGV
E
IK
V
V
DD
ARK
T
LP
P
G
C
E
GE
EAS
R
---
GP
NV
F
M
GYF
DE
P
E
L
TA
R
ALD
E
E
GWY
Y
SGDL
CRM
DE
A
GYI
KIT
GR
K
KD
I
I
V
RGGENIS
SR
E
V
E
D
ILL
Q
HPKI
H
DA
C
VV
A
M
P
DE
RL
GE
R
SCAYVVLK
A
P
H
HS
LS
L
EEV
V
A
F
FS
RK
R
V
AK
Y
K
Y
P
EH
I
V
VI
E
K
LPRT
V
SGKI
Q
K
F
L
LR
KDIMR
RLTQDVCEEIE
fig|340197.3.peg.1839
Escherichia coli F11 (19-566/566)
MKVTLTFNEQRRAAYR
QQ
G
L
W
G
D
AS
LAD
YW
-
QQ
TA
R
A
MP
D
K
IAVVD
NH
G
AT
Y
T
Y
S
A
L
DH
AA
S
C
LAN
WMLAK
GI
E
S
GD
RI
A
F
QL
P
G
WC
EF
TVI
Y
L
A
C
LK
T
GA
VS
VP
L
L
P
S
WR
E
A
EL
V
W
V
L
NKC
QA
KMFFAP
T
----
LFK
Q
T
R
P
VD
LI
LPL
Q
NQ
L
P
QL
QQ
I
VGV
D
KLAP
A
T
SS
L
-
S
LS
Q
I
L
A
D
----------
N
T
P
L
T
--
TA
I
T
VHG
DE
L
A
AV
LFTSGT
E
G
L
PKGV
ML
THNN
ILA
S
E
R
A
Y
CAR
L
N
LT
W
QDV
FM
MPA
P
L
G
H
ATGFLH
G
VT
AP
-----
FL
I
GA
R
S
VL
LDIF
TP
D
AC
LA
L
L
E
Q
Q
R
C
T
C
M
LGA
T
P
F
V
-
Y
D
L
L
N
L
L
E--
K
QP
A
D
L
SA
L
R
F
F
L
C
GG
TT
IP
KKV-
AR
E
C
Q
Q
R
G
I
K
LL
S
VYG
S
TE
SSP
HA
V
VN
---
LDDP
LP
R
----
F
M
HT
D
GY
AA
-
AGV
E
IK
V
V
DD
ARK
T
LP
P
G
C
E
GE
EAS
R
---
GP
NV
F
M
GYF
DE
P
E
L
TA
R
ALD
E
E
GWY
Y
SGDL
CRM
DE
A
GYI
KIT
GR
K
KD
I
I
V
RGGENIS
SR
E
V
E
D
ILL
Q
HPKI
H
DA
C
VV
A
M
P
DE
RL
GE
R
SCAYVVLK
A
P
H
HS
LS
L
EEV
V
A
F
FS
RK
R
V
AK
Y
K
Y
P
EH
I
V
VI
E
K
LPRT
V
SGKI
Q
K
F
L
LR
KDIMR
RLTQDVCEEIE
fig|364106.7.peg.1934
Escherichia coli UTI89
MKVTLTFNEQRRAAYR
QQ
G
L
W
G
D
AS
LAD
YW
-
QQ
TA
R
A
MP
D
K
IAVVD
NH
G
AT
Y
T
Y
S
A
L
DH
AA
S
C
LAN
WMLAK
GI
E
S
GD
RI
A
F
QL
P
G
WC
EF
TVI
Y
L
A
C
LK
T
GA
VS
VP
L
L
P
S
WR
E
A
EL
V
W
V
L
NKC
QA
KMFFAP
T
----
LFK
Q
T
R
P
VD
LI
LPL
Q
NQ
L
P
QL
QQ
I
VGV
D
KLAP
A
T
SS
L
-
S
LS
Q
I
L
A
D
----------
N
T
P
L
T
--
TA
I
T
THG
DE
L
A
AV
LFTSGT
E
G
L
PKGV
ML
THNN
ILA
S
E
R
A
Y
CAR
L
N
LT
W
QDV
FM
MPA
P
L
G
H
ATGFLH
G
VT
AP
-----
FL
I
GA
R
S
VL
LDIF
TP
D
AC
LA
L
L
E
Q
Q
R
C
T
C
M
LGA
T
P
F
V
-
Y
D
L
L
N
L
L
E--
K
QP
A
D
L
SA
L
R
F
F
L
C
GG
TT
IP
KKV-
AR
E
C
Q
Q
R
G
I
K
LL
S
VYG
S
TE
SSP
HA
V
VN
---
LDDP
LP
R
----
F
M
HT
D
GY
AA
-
AGV
E
IK
V
V
DD
ARK
T
LP
P
G
C
E
GE
EAS
R
---
GP
NV
F
M
GYF
DE
P
E
L
TA
R
ALD
E
E
GWY
Y
SGDL
CRM
DE
A
GYI
KIT
GR
N
KD
I
I
V
RGGENIS
SR
E
V
E
D
ILL
Q
HPKI
H
DA
C
VV
A
M
P
DE
RL
GE
R
SCAYVVLK
A
P
H
HS
LS
L
EEV
V
A
F
FS
RK
R
V
AK
Y
K
Y
P
EH
I
V
VI
E
K
LPRT
V
SGKI
Q
K
F
L
LR
KDIMR
RLTQDVCEEIE
fig|364106.8.peg.1937
Escherichia coli UTI89
MKVTLTFNEQRRAAYR
QQ
G
L
W
G
D
AS
LAD
YW
-
QQ
TA
R
A
MP
D
K
IAVVD
NH
G
AT
Y
T
Y
S
A
L
DH
AA
S
C
LAN
WMLAK
GI
E
S
GD
RI
A
F
QL
P
G
WC
EF
TVI
Y
L
A
C
LK
T
GA
VS
VP
L
L
P
S
WR
E
A
EL
V
W
V
L
NKC
QA
KMFFAP
T
----
LFK
Q
T
R
P
VD
LI
LPL
Q
NQ
L
P
QL
QQ
I
VGV
D
KLAP
A
T
SS
L
-
S
LS
Q
I
L
A
D
----------
N
T
P
L
T
--
TA
I
T
THG
DE
L
A
AV
LFTSGT
E
G
L
PKGV
ML
THNN
ILA
S
E
R
A
Y
CAR
L
N
LT
W
QDV
FM
MPA
P
L
G
H
ATGFLH
G
VT
AP
-----
FL
I
GA
R
S
VL
LDIF
TP
D
AC
LA
L
L
E
Q
Q
R
C
T
C
M
LGA
T
P
F
V
-
Y
D
L
L
N
L
L
E--
K
QP
A
D
L
SA
L
R
F
F
L
C
GG
TT
IP
KKV-
AR
E
C
Q
Q
R
G
I
K
LL
S
VYG
S
TE
SSP
HA
V
VN
---
LDDP
LP
R
----
F
M
HT
D
GY
AA
-
AGV
E
IK
V
V
DD
ARK
T
LP
P
G
C
E
GE
EAS
R
---
GP
NV
F
M
GYF
DE
P
E
L
TA
R
ALD
E
E
GWY
Y
SGDL
CRM
DE
A
GYI
KIT
GR
N
KD
I
I
V
RGGENIS
SR
E
V
E
D
ILL
Q
HPKI
H
DA
C
VV
A
M
P
DE
RL
GE
R
SCAYVVLK
A
P
H
HS
LS
L
EEV
V
A
F
FS
RK
R
V
AK
Y
K
Y
P
EH
I
V
VI
E
K
LPRT
V
SGKI
Q
K
F
L
LR
KDIMR
RLTQDVCEEIE
fig|595496.3.peg.1662
Escherichia coli BW2952 (19-566/566)
MKVTLTFNEQRRAAYR
QQ
G
L
W
G
D
AS
LAD
YW
-
QQ
TA
R
A
MP
D
K
IAVVD
NH
G
AS
Y
T
Y
S
A
L
DH
AA
S
C
LAN
WMLAK
GI
E
S
GD
RI
A
F
QL
P
G
WC
EF
TVI
Y
L
A
C
LKIGA
VS
VP
L
L
P
S
WR
E
A
EL
V
W
V
L
NKC
QA
KMFFAP
T
----
LFK
Q
T
R
P
VD
LI
LPL
Q
NQ
L
P
QL
QQ
I
VGV
D
KLAP
A
T
SS
L
-
S
LS
Q
I
I
A
D
----------
N
T
S
L
T
--
TA
I
T
THG
DE
L
A
AV
LFTSGT
E
G
L
PKGV
ML
THNN
ILA
S
E
R
A
Y
CAR
L
N
LT
W
QDV
FM
MPA
P
L
G
H
ATGFLH
G
VT
AP
-----
FL
I
GA
R
S
VL
LDIF
TP
D
AC
LA
L
L
E
Q
Q
R
C
T
C
M
LGA
T
P
F
V
-
Y
D
L
L
N
V
L
E--
K
QP
A
D
L
SA
L
R
F
F
L
C
GG
TT
IP
KKV-
AR
E
C
Q
Q
R
G
I
K
LL
S
VYG
S
TE
SSP
HA
V
VN
---
LDDP
LS
R
----
F
M
HT
D
GY
AA
-
AGV
E
IK
V
V
DD
ARK
T
LP
P
G
C
E
GE
EAS
R
---
GP
NV
F
M
GYF
DE
P
E
L
TA
R
ALD
E
E
GWY
Y
SGDL
CRM
DE
A
GYI
KIT
GR
K
KD
I
I
V
RGGENIS
SR
E
V
E
D
ILL
Q
HPKI
H
DA
C
VV
A
M
S
DE
RL
GE
R
SCAYVVLK
A
P
H
HS
LS
L
EEV
V
A
F
FS
RK
R
V
AK
Y
K
Y
P
EH
I
V
VI
E
K
LPRT
T
SGKI
Q
K
F
L
LR
KDIMR
RLTQDVCEEIE
fig|316407.3.peg.1657
Escherichia coli W3110 (19-566/566)
MKVTLTFNEQRRAAYR
QQ
G
L
W
G
D
AS
LAD
YW
-
QQ
TA
R
A
MP
D
K
IAVVD
NH
G
AS
Y
T
Y
S
A
L
DH
AA
S
C
LAN
WMLAK
GI
E
S
GD
RI
A
F
QL
P
G
WC
EF
TVI
Y
L
A
C
LKIGA
VS
VP
L
L
P
S
WR
E
A
EL
V
W
V
L
NKC
QA
KMFFAP
T
----
LFK
Q
T
R
P
VD
LI
LPL
Q
NQ
L
P
QL
QQ
I
VGV
D
KLAP
A
T
SS
L
-
S
LS
Q
I
I
A
D
----------
N
T
S
L
T
--
TA
I
T
THG
DE
L
A
AV
LFTSGT
E
G
L
PKGV
ML
THNN
ILA
S
E
R
A
Y
CAR
L
N
LT
W
QDV
FM
MPA
P
L
G
H
ATGFLH
G
VT
AP
-----
FL
I
GA
R
S
VL
LDIF
TP
D
AC
LA
L
L
E
Q
Q
R
C
T
C
M
LGA
T
P
F
V
-
Y
D
L
L
N
V
L
E--
K
QP
A
D
L
SA
L
R
F
F
L
C
GG
TT
IP
KKV-
AR
E
C
Q
Q
R
G
I
K
LL
S
VYG
S
TE
SSP
HA
V
VN
---
LDDP
LS
R
----
F
M
HT
D
GY
AA
-
AGV
E
IK
V
V
DD
ARK
T
LP
P
G
C
E
GE
EAS
R
---
GP
NV
F
M
GYF
DE
P
E
L
TA
R
ALD
E
E
GWY
Y
SGDL
CRM
DE
A
GYI
KIT
GR
K
KD
I
I
V
RGGENIS
SR
E
V
E
D
ILL
Q
HPKI
H
DA
C
VV
A
M
S
DE
RL
GE
R
SCAYVVLK
A
P
H
HS
LS
L
EEV
V
A
F
FS
RK
R
V
AK
Y
K
Y
P
EH
I
V
VI
E
K
LPRT
T
SGKI
Q
K
F
L
LR
KDIMR
RLTQDVCEEIE
fig|316385.5.peg.1814
Escherichia coli str. K-12 substr. DH10B (19-566/566)
MKVTLTFNEQRRAAYR
QQ
G
L
W
G
D
AS
LAD
YW
-
QQ
TA
R
A
MP
D
K
IAVVD
NH
G
AS
Y
T
Y
S
A
L
DH
AA
S
C
LAN
WMLAK
GI
E
S
GD
RI
A
F
QL
P
G
WC
EF
TVI
Y
L
A
C
LKIGA
VS
VP
L
L
P
S
WR
E
A
EL
V
W
V
L
NKC
QA
KMFFAP
T
----
LFK
Q
T
R
P
VD
LI
LPL
Q
NQ
L
P
QL
QQ
I
VGV
D
KLAP
A
T
SS
L
-
S
LS
Q
I
I
A
D
----------
N
T
S
L
T
--
TA
I
T
THG
DE
L
A
AV
LFTSGT
E
G
L
PKGV
ML
THNN
ILA
S
E
R
A
Y
CAR
L
N
LT
W
QDV
FM
MPA
P
L
G
H
ATGFLH
G
VT
AP
-----
FL
I
GA
R
S
VL
LDIF
TP
D
AC
LA
L
L
E
Q
Q
R
C
T
C
M
LGA
T
P
F
V
-
Y
D
L
L
N
V
L
E--
K
QP
A
D
L
SA
L
R
F
F
L
C
GG
TT
IP
KKV-
AR
E
C
Q
Q
R
G
I
K
LL
S
VYG
S
TE
SSP
HA
V
VN
---
LDDP
LS
R
----
F
M
HT
D
GY
AA
-
AGV
E
IK
V
V
DD
ARK
T
LP
P
G
C
E
GE
EAS
R
---
GP
NV
F
M
GYF
DE
P
E
L
TA
R
ALD
E
E
GWY
Y
SGDL
CRM
DE
A
GYI
KIT
GR
K
KD
I
I
V
RGGENIS
SR
E
V
E
D
ILL
Q
HPKI
H
DA
C
VV
A
M
S
DE
RL
GE
R
SCAYVVLK
A
P
H
HS
LS
L
EEV
V
A
F
FS
RK
R
V
AK
Y
K
Y
P
EH
I
V
VI
E
K
LPRT
T
SGKI
Q
K
F
L
LR
KDIMR
RLTQDVCEEIE
fig|316385.7.peg.1860
Escherichia coli str. K-12 substr. DH10B (19-566/566)
MKVTLTFNEQRRAAYR
QQ
G
L
W
G
D
AS
LAD
YW
-
QQ
TA
R
A
MP
D
K
IAVVD
NH
G
AS
Y
T
Y
S
A
L
DH
AA
S
C
LAN
WMLAK
GI
E
S
GD
RI
A
F
QL
P
G
WC
EF
TVI
Y
L
A
C
LKIGA
VS
VP
L
L
P
S
WR
E
A
EL
V
W
V
L
NKC
QA
KMFFAP
T
----
LFK
Q
T
R
P
VD
LI
LPL
Q
NQ
L
P
QL
QQ
I
VGV
D
KLAP
A
T
SS
L
-
S
LS
Q
I
I
A
D
----------
N
T
S
L
T
--
TA
I
T
THG
DE
L
A
AV
LFTSGT
E
G
L
PKGV
ML
THNN
ILA
S
E
R
A
Y
CAR
L
N
LT
W
QDV
FM
MPA
P
L
G
H
ATGFLH
G
VT
AP
-----
FL
I
GA
R
S
VL
LDIF
TP
D
AC
LA
L
L
E
Q
Q
R
C
T
C
M
LGA
T
P
F
V
-
Y
D
L
L
N
V
L
E--
K
QP
A
D
L
SA
L
R
F
F
L
C
GG
TT
IP
KKV-
AR
E
C
Q
Q
R
G
I
K
LL
S
VYG
S
TE
SSP
HA
V
VN
---
LDDP
LS
R
----
F
M
HT
D
GY
AA
-
AGV
E
IK
V
V
DD
ARK
T
LP
P
G
C
E
GE
EAS
R
---
GP
NV
F
M
GYF
DE
P
E
L
TA
R
ALD
E
E
GWY
Y
SGDL
CRM
DE
A
GYI
KIT
GR
K
KD
I
I
V
RGGENIS
SR
E
V
E
D
ILL
Q
HPKI
H
DA
C
VV
A
M
S
DE
RL
GE
R
SCAYVVLK
A
P
H
HS
LS
L
EEV
V
A
F
FS
RK
R
V
AK
Y
K
Y
P
EH
I
V
VI
E
K
LPRT
T
SGKI
Q
K
F
L
LR
KDIMR
RLTQDVCEEIE
fig|511145.6.peg.1757
Escherichia coli str. K-12 substr. MG1655 (19-566/566)
MKVTLTFNEQRRAAYR
QQ
G
L
W
G
D
AS
LAD
YW
-
QQ
TA
R
A
MP
D
K
IAVVD
NH
G
AS
Y
T
Y
S
A
L
DH
AA
S
C
LAN
WMLAK
GI
E
S
GD
RI
A
F
QL
P
G
WC
EF
TVI
Y
L
A
C
LKIGA
VS
VP
L
L
P
S
WR
E
A
EL
V
W
V
L
NKC
QA
KMFFAP
T
----
LFK
Q
T
R
P
VD
LI
LPL
Q
NQ
L
P
QL
QQ
I
VGV
D
KLAP
A
T
SS
L
-
S
LS
Q
I
I
A
D
----------
N
T
S
L
T
--
TA
I
T
THG
DE
L
A
AV
LFTSGT
E
G
L
PKGV
ML
THNN
ILA
S
E
R
A
Y
CAR
L
N
LT
W
QDV
FM
MPA
P
L
G
H
ATGFLH
G
VT
AP
-----
FL
I
GA
R
S
VL
LDIF
TP
D
AC
LA
L
L
E
Q
Q
R
C
T
C
M
LGA
T
P
F
V
-
Y
D
L
L
N
V
L
E--
K
QP
A
D
L
SA
L
R
F
F
L
C
GG
TT
IP
KKV-
AR
E
C
Q
Q
R
G
I
K
LL
S
VYG
S
TE
SSP
HA
V
VN
---
LDDP
LS
R
----
F
M
HT
D
GY
AA
-
AGV
E
IK
V
V
DD
ARK
T
LP
P
G
C
E
GE
EAS
R
---
GP
NV
F
M
GYF
DE
P
E
L
TA
R
ALD
E
E
GWY
Y
SGDL
CRM
DE
A
GYI
KIT
GR
K
KD
I
I
V
RGGENIS
SR
E
V
E
D
ILL
Q
HPKI
H
DA
C
VV
A
M
S
DE
RL
GE
R
SCAYVVLK
A
P
H
HS
LS
L
EEV
V
A
F
FS
RK
R
V
AK
Y
K
Y
P
EH
I
V
VI
E
K
LPRT
T
SGKI
Q
K
F
L
LR
KDIMR
RLTQDVCEEIE
fig|536056.3.peg.2052
Escherichia coli DH1
MKVTLTFNEQRRAAYR
QQ
G
L
W
G
D
AS
LAD
YW
-
QQ
TA
R
A
MP
D
K
IAVVD
NH
G
AS
Y
T
Y
S
A
L
DH
AA
S
C
LAN
WMLAK
GI
E
S
GD
RI
A
F
QL
P
G
WC
EF
TVI
Y
L
A
C
LKIGA
VS
VP
L
L
P
S
WR
E
A
EL
V
W
V
L
NKC
QA
KMFFAP
T
----
LFK
Q
T
R
P
VD
LI
LPL
Q
NQ
L
P
QL
QQ
I
VGV
D
KLAP
A
T
SS
L
-
S
LS
Q
I
I
A
D
----------
N
T
S
L
T
--
TA
I
T
THG
DE
L
A
AV
LFTSGT
E
G
L
PKGV
ML
THNN
ILA
S
E
R
A
Y
CAR
L
N
LT
W
QDV
FM
MPA
P
L
G
H
ATGFLH
G
VT
AP
-----
FL
I
GA
R
S
VL
LDIF
TP
D
AC
LA
L
L
E
Q
Q
R
C
T
C
M
LGA
T
P
F
V
-
Y
D
L
L
N
V
L
E--
K
QP
A
D
L
SA
L
R
F
F
L
C
GG
TT
IP
KKV-
AR
E
C
Q
Q
R
G
I
K
LL
S
VYG
S
TE
SSP
HA
V
VN
---
LDDP
LS
R
----
F
M
HT
D
GY
AA
-
AGV
E
IK
V
V
DD
ARK
T
LP
P
G
C
E
GE
EAS
R
---
GP
NV
F
M
GYF
DE
P
E
L
TA
R
ALD
E
E
GWY
Y
SGDL
CRM
DE
A
GYI
KIT
GR
K
KD
I
I
V
RGGENIS
SR
E
V
E
D
ILL
Q
HPKI
H
DA
C
VV
A
M
S
DE
RL
GE
R
SCAYVVLK
A
P
H
HS
LS
L
EEV
V
A
F
FS
RK
R
V
AK
Y
K
Y
P
EH
I
V
VI
E
K
LPRT
T
SGKI
Q
K
F
L
LR
KDIMR
RLTQDVCEEIE
fig|83333.1.peg.1685
Escherichia coli K12
MKVTLTFNEQRRAAYR
QQ
G
L
W
G
D
AS
LAD
YW
-
QQ
TA
R
A
MP
D
K
IAVVD
NH
G
AS
Y
T
Y
S
A
L
DH
AA
S
C
LAN
WMLAK
GI
E
S
GD
RI
A
F
QL
P
G
WC
EF
TVI
Y
L
A
C
LKIGA
VS
VP
L
L
P
S
WR
E
A
EL
V
W
V
L
NKC
QA
KMFFAP
T
----
LFK
Q
T
R
P
VD
LI
LPL
Q
NQ
L
P
QL
QQ
I
VGV
D
KLAP
A
T
SS
L
-
S
LS
Q
I
I
A
D
----------
N
T
S
L
T
--
TA
I
T
THG
DE
L
A
AV
LFTSGT
E
G
L
PKGV
ML
THNN
ILA
S
E
R
A
Y
CAR
L
N
LT
W
QDV
FM
MPA
P
L
G
H
ATGFLH
G
VT
AP
-----
FL
I
GA
R
S
VL
LDIF
TP
D
AC
LA
L
L
E
Q
Q
R
C
T
C
M
LGA
T
P
F
V
-
Y
D
L
L
N
V
L
E--
K
QP
A
D
L
SA
L
R
F
F
L
C
GG
TT
IP
KKV-
AR
E
C
Q
Q
R
G
I
K
LL
S
VYG
S
TE
SSP
HA
V
VN
---
LDDP
LS
R
----
F
M
HT
D
GY
AA
-
AGV
E
IK
V
V
DD
ARK
T
LP
P
G
C
E
GE
EAS
R
---
GP
NV
F
M
GYF
DE
P
E
L
TA
R
ALD
E
E
GWY
Y
SGDL
CRM
DE
A
GYI
KIT
GR
K
KD
I
I
V
RGGENIS
SR
E
V
E
D
ILL
Q
HPKI
H
DA
C
VV
A
M
S
DE
RL
GE
R
SCAYVVLK
A
P
H
HS
LS
L
EEV
V
A
F
FS
RK
R
V
AK
Y
K
Y
P
EH
I
V
VI
E
K
LPRT
T
SGKI
Q
K
F
L
LR
KDIMR
RLTQDVCEEIE
fig|749538.3.peg.4682
Escherichia coli MS 116-1
MKVTLTFNEQRRAAYR
QQ
G
L
W
G
D
AS
LAD
YW
-
QQ
TA
R
A
MP
D
K
IAVVD
NH
G
AS
Y
T
Y
S
A
L
DH
AA
S
C
LAN
WMLAK
GI
E
S
GD
RI
A
F
QL
P
G
WC
EF
TVI
Y
L
A
C
LKIGA
VS
VP
L
L
P
S
WR
E
A
EL
V
W
V
L
NKC
QA
KMFFAP
T
----
LFK
Q
T
R
P
VD
LI
LPL
Q
NQ
L
P
QL
QQ
I
VGV
D
KLAP
A
T
SS
L
-
S
LS
Q
I
I
A
D
----------
N
T
S
L
T
--
TA
I
T
THG
DE
L
A
AV
LFTSGT
E
G
L
PKGV
ML
THNN
ILA
S
E
R
A
Y
CAR
L
N
LT
W
QDV
FM
MPA
P
L
G
H
ATGFLH
G
VT
AP
-----
FL
I
GA
R
S
VL
LDIF
TP
D
AC
LA
L
L
E
Q
Q
R
C
T
C
M
LGA
T
P
F
V
-
Y
D
L
L
N
V
L
E--
K
QP
A
D
L
SA
L
R
F
F
L
C
GG
TT
IP
KKV-
AR
E
C
Q
Q
R
G
I
K
LL
S
VYG
S
TE
SSP
HA
V
VN
---
LDDP
LS
R
----
F
M
HT
D
GY
AA
-
AGV
E
IK
V
V
DD
ARK
T
LP
P
G
C
E
GE
EAS
R
---
GP
NV
F
M
GYF
DE
P
E
L
TA
R
ALD
E
E
GWY
Y
SGDL
CRM
DE
A
GYI
KIT
GR
K
KD
I
I
V
RGGENIS
SR
E
V
E
D
ILL
Q
HPKI
H
DA
C
VV
A
M
S
DE
RL
GE
R
SCAYVVLK
A
P
H
HS
LS
L
EEV
V
A
F
FS
RK
R
V
AK
Y
K
Y
P
EH
I
V
VI
E
K
LPRT
T
SGKI
Q
K
F
L
LR
KDIMR
RLTQDVCEEIE
fig|749548.3.peg.3581
Escherichia coli MS 196-1
MKVTLTFNEQRRAAYR
QQ
G
L
W
G
D
AS
LAD
YW
-
QQ
TA
R
A
MP
D
K
IAVVD
NH
G
AS
Y
T
Y
S
A
L
DH
AA
S
C
LAN
WMLAK
GI
E
S
GD
RI
A
F
QL
P
G
WC
EF
TVI
Y
L
A
C
LKIGA
VS
VP
L
L
P
S
WR
E
A
EL
V
W
V
L
NKC
QA
KMFFAP
T
----
LFK
Q
T
R
P
VD
LI
LPL
Q
NQ
L
P
QL
QQ
I
VGV
D
KLAP
A
T
SS
L
-
S
LS
Q
I
I
A
D
----------
N
T
S
L
T
--
TA
I
T
THG
DE
L
A
AV
LFTSGT
E
G
L
PKGV
ML
THNN
ILA
S
E
R
A
Y
CAR
L
N
LT
W
QDV
FM
MPA
P
L
G
H
ATGFLH
G
VT
AP
-----
FL
I
GA
R
S
VL
LDIF
TP
D
AC
LA
L
L
E
Q
Q
R
C
T
C
M
LGA
T
P
F
V
-
Y
D
L
L
N
V
L
E--
K
QP
A
D
L
SA
L
R
F
F
L
C
GG
TT
IP
KKV-
AR
E
C
Q
Q
R
G
I
K
LL
S
VYG
S
TE
SSP
HA
V
VN
---
LDDP
LS
R
----
F
M
HT
D
GY
AA
-
AGV
E
IK
V
V
DD
ARK
T
LP
P
G
C
E
GE
EAS
R
---
GP
NV
F
M
GYF
DE
P
E
L
TA
R
ALD
E
E
GWY
Y
SGDL
CRM
DE
A
GYI
KIT
GR
K
KD
I
I
V
RGGENIS
SR
E
V
E
D
ILL
Q
HPKI
H
DA
C
VV
A
M
S
DE
RL
GE
R
SCAYVVLK
A
P
H
HS
LS
L
EEV
V
A
F
FS
RK
R
V
AK
Y
K
Y
P
EH
I
V
VI
E
K
LPRT
T
SGKI
Q
K
F
L
LR
KDIMR
RLTQDVCEEIE
fig|511145.12.peg.1772
Escherichia coli str. K-12 substr. MG1655
MKVTLTFNEQRRAAYR
QQ
G
L
W
G
D
AS
LAD
YW
-
QQ
TA
R
A
MP
D
K
IAVVD
NH
G
AS
Y
T
Y
S
A
L
DH
AA
S
C
LAN
WMLAK
GI
E
S
GD
RI
A
F
QL
P
G
WC
EF
TVI
Y
L
A
C
LKIGA
VS
VP
L
L
P
S
WR
E
A
EL
V
W
V
L
NKC
QA
KMFFAP
T
----
LFK
Q
T
R
P
VD
LI
LPL
Q
NQ
L
P
QL
QQ
I
VGV
D
KLAP
A
T
SS
L
-
S
LS
Q
I
I
A
D
----------
N
T
S
L
T
--
TA
I
T
THG
DE
L
A
AV
LFTSGT
E
G
L
PKGV
ML
THNN
ILA
S
E
R
A
Y
CAR
L
N
LT
W
QDV
FM
MPA
P
L
G
H
ATGFLH
G
VT
AP
-----
FL
I
GA
R
S
VL
LDIF
TP
D
AC
LA
L
L
E
Q
Q
R
C
T
C
M
LGA
T
P
F
V
-
Y
D
L
L
N
V
L
E--
K
QP
A
D
L
SA
L
R
F
F
L
C
GG
TT
IP
KKV-
AR
E
C
Q
Q
R
G
I
K
LL
S
VYG
S
TE
SSP
HA
V
VN
---
LDDP
LS
R
----
F
M
HT
D
GY
AA
-
AGV
E
IK
V
V
DD
ARK
T
LP
P
G
C
E
GE
EAS
R
---
GP
NV
F
M
GYF
DE
P
E
L
TA
R
ALD
E
E
GWY
Y
SGDL
CRM
DE
A
GYI
KIT
GR
K
KD
I
I
V
RGGENIS
SR
E
V
E
D
ILL
Q
HPKI
H
DA
C
VV
A
M
S
DE
RL
GE
R
SCAYVVLK
A
P
H
HS
LS
L
EEV
V
A
F
FS
RK
R
V
AK
Y
K
Y
P
EH
I
V
VI
E
K
LPRT
T
SGKI
Q
K
F
L
LR
KDIMR
RLTQDVCEEIE
fig|749531.3.peg.4837
Escherichia coli MS 69-1
MKVTLTFNEQRRAAYR
QQ
G
L
W
G
D
AS
LAD
YW
-
QQ
TA
R
A
MP
D
K
IAVVD
NH
G
AS
Y
T
Y
S
A
L
DH
AA
S
C
LAN
WMLAK
GI
E
S
GD
RI
A
F
QL
P
G
WC
EF
TVI
Y
L
A
C
LKIGA
VS
VP
L
L
P
S
WR
E
A
EL
V
W
V
L
NKC
QA
KMFFAP
T
----
LFK
Q
T
R
P
VD
LI
LPL
Q
NQ
L
P
QL
QQ
I
VGV
D
KLAP
A
T
S
AL
-
S
LS
Q
I
I
A
D
----------
N
T
P
L
T
--
TA
I
T
VHG
DE
L
A
AV
LFTSGT
E
G
L
PKGV
ML
THNN
ILA
S
E
R
A
Y
CAR
L
N
LT
W
QDV
FM
MPA
P
L
G
H
ATGFLH
G
VT
AP
-----
FL
I
GA
R
S
VL
LDIF
TP
A
AC
LA
L
L
E
Q
Q
R
C
T
C
M
LGA
T
P
F
V
-
Y
D
L
L
N
L
L
E--
K
QP
A
D
L
SA
L
R
F
F
L
C
GG
TT
IP
KKV-
AR
E
C
Q
Q
R
G
I
K
LL
S
VYG
S
TE
SSP
HA
V
VN
---
LDDP
LS
R
----
F
M
HT
D
GY
AV
-
AGV
E
IK
V
V
DD
ARK
T
LP
P
G
C
E
GE
EAS
R
---
GP
NV
F
M
GYF
DE
P
E
L
TA
R
ALD
E
E
GWY
Y
SGDL
CRM
DE
A
GYI
KIT
GR
K
KD
I
I
V
RGGENIS
SR
E
V
E
D
ILL
Q
HPKI
H
DA
C
VV
A
M
P
DE
RL
GE
R
SCAYVVLK
A
P
H
HS
LS
L
EEV
V
A
F
FS
RK
R
IAK
Y
K
Y
P
EH
I
V
VI
E
K
LPRT
V
SGKI
Q
K
F
L
LR
KDIMR
RLTQDVCEEIE
fig|656437.3.peg.1927
Escherichia coli TA143
MKVTLTFNEQRRAAYR
QQ
G
L
W
G
D
AS
LAD
YW
-
QQ
TA
R
A
MP
D
K
IAVVD
NH
G
AS
Y
T
Y
S
A
L
DH
AA
S
C
LAN
WMLAK
GI
E
S
GD
RI
A
F
QL
P
G
WC
EF
TVI
Y
L
A
C
LKIGA
VS
VP
L
L
P
S
WR
E
A
EL
V
W
V
L
NKC
QA
KMFFAP
T
----
LFK
Q
T
R
P
VD
LI
LPL
Q
NQ
L
P
QL
QQ
I
VGV
D
KLAP
A
T
SS
L
-
S
LS
Q
I
I
A
D
----------
N
T
P
L
T
--
TA
I
T
VHG
DE
L
A
VV
LFTSGT
E
G
L
PKGV
ML
THNN
ILA
S
E
R
A
Y
CAR
L
N
LT
W
QDV
FM
MPA
P
L
G
H
ATGFLH
G
VT
AP
-----
FL
I
GA
R
S
VL
LDIF
TP
D
AC
LA
L
L
E
Q
Q
R
C
T
C
M
LGA
T
P
F
V
-
Y
D
L
L
N
L
L
E--
K
QP
A
D
L
SA
L
R
F
F
L
C
GG
TT
IP
KKV-
AR
E
C
Q
Q
H
G
I
K
LL
S
VYG
S
TE
SSP
HA
V
VN
---
LDDP
LS
R
----
F
M
HT
D
GY
AA
-
AGV
E
IK
V
V
DD
ARK
T
LP
P
G
Y
E
GE
EAS
R
---
GP
NV
F
M
GYF
DE
P
E
L
TA
R
ALD
E
E
GWY
Y
SGDL
CRM
DE
A
GYI
KIT
GR
K
KD
I
I
V
RGGENIS
SR
E
V
E
D
ILL
Q
HPKI
H
DA
C
VV
A
M
P
DE
RL
GE
R
SCAYVVLK
A
P
H
HS
LS
L
EEV
V
A
F
FS
RK
R
V
AK
Y
K
Y
P
EH
I
V
VI
E
K
LPRT
A
SGKI
Q
K
F
L
LR
KDIMR
RLTQDVCEEIE
fig|550677.3.peg.1193
Escherichia coli B354
MKVTLTFNEQRRAAYR
QQ
G
L
W
G
D
AS
LAD
YW
-
QQ
TA
R
A
MP
D
K
IAVVD
NH
G
AS
Y
T
Y
S
A
L
DH
AA
S
C
LAN
WMLAK
GI
E
S
GD
RI
A
F
QL
P
G
WC
EF
TVI
Y
L
A
C
LKIGA
VS
VP
L
L
P
S
WR
E
A
EL
V
W
V
L
NKC
QA
KMFFAP
T
----
LFK
Q
T
R
P
VD
LI
LPL
Q
NQ
L
P
QL
QQ
I
VGV
D
KLAP
A
T
S
AL
-
S
LS
Q
I
I
A
D
----------
N
T
P
L
T
--
TA
I
T
VHG
DE
L
A
AV
LFTSGT
E
G
L
PKGV
ML
THNN
ILA
S
E
R
A
Y
CAR
L
N
LT
W
QDV
FM
MPA
P
L
G
H
ATGFLH
G
VT
AP
-----
FL
I
GA
R
S
VL
LDIF
TP
D
AC
LA
L
L
E
Q
Q
R
C
T
C
M
LGA
T
P
F
V
-
Y
D
L
L
N
L
L
E--
K
QP
A
D
L
SA
L
R
F
F
L
C
GG
TT
IP
KKV-
AR
E
C
Q
Q
R
G
I
K
LL
S
VYG
S
TE
SSP
HA
V
VN
---
LDDP
LS
R
----
F
M
HT
D
GY
AA
-
AGV
E
IK
V
V
DD
ARK
T
LP
P
G
Y
E
GE
EAS
R
---
GP
NV
F
M
GYF
DE
P
E
L
TA
R
ALD
E
E
GWY
Y
SGDL
CRM
DE
A
GYI
KIT
GR
K
KD
I
I
V
RGGENIS
SR
E
V
E
D
ILL
Q
HPKI
H
DA
C
VV
A
M
P
DE
RL
GE
R
SCAYVVLK
A
P
H
HS
LS
L
EEV
V
A
F
FS
RK
R
V
AK
Y
K
Y
P
EH
I
V
VI
E
K
LPRT
A
SGKI
Q
K
F
L
LR
KDIM
L
RLTQDVCEEIE
fig|749550.3.peg.3168
Escherichia coli MS 200-1
MKVTLTFNEQRRAAYR
QQ
G
L
W
G
D
AS
LAD
YW
-
QQ
TA
R
A
MP
D
N
IAVVD
NH
G
AT
Y
T
Y
S
A
L
DH
AA
S
C
LAN
WMLAK
GI
E
S
GD
RI
A
F
QL
P
G
WC
EF
TVI
Y
L
A
C
LK
T
GA
VS
VP
L
L
P
S
WR
E
A
EL
V
W
V
L
NKC
QA
KMFFAP
T
----
LFK
Q
T
R
P
VD
LI
LPL
Q
NQ
L
P
QL
QQ
I
VGV
D
KLAP
A
T
SS
L
-
S
LS
Q
I
L
A
D
----------
N
T
P
L
T
--
TA
I
T
VHG
DE
L
A
AV
LFTSGT
E
G
L
PKGV
ML
THNN
ILA
S
E
R
A
Y
CAR
L
N
LT
W
QDV
FM
MPA
P
L
G
H
ATGFLH
G
VT
AP
-----
FL
I
GA
R
S
VL
LDIF
TP
D
AC
LA
L
L
E
Q
Q
R
C
T
C
M
LGA
T
P
F
V
-
Y
D
L
L
N
L
L
E--
K
QP
A
D
L
SA
L
R
F
F
L
C
GG
TT
IP
KKV-
AR
E
C
Q
Q
R
G
I
K
LL
S
VYG
S
TE
SSP
HA
V
VN
---
LDDP
LP
R
----
F
M
HT
D
GY
AA
-
AGV
E
IK
V
V
DD
ARK
T
LP
P
G
C
E
GE
EAS
R
---
GP
NV
F
M
GYF
DE
P
E
L
TA
R
ALD
E
E
GWY
Y
SGDL
CRM
DE
A
GYI
KIT
GR
K
KD
I
I
V
RGGENIS
SR
E
V
E
D
ILL
Q
HPKI
H
DA
C
VV
A
M
P
DE
RL
GE
R
SCAYVVLK
A
P
H
HS
LS
L
EEV
V
A
F
FS
RK
R
V
AK
Y
K
Y
P
EH
I
V
VI
E
K
LPRT
V
SGKI
Q
K
F
L
LR
KDIMR
RLTQDVCEEIE
fig|753642.3.peg.3263
Escherichia coli NC101
MKVTLTFNEQRRAAYR
QQ
G
L
W
G
D
AS
LAD
YW
-
QQ
TA
R
A
MP
D
K
IAVVD
NH
G
AT
Y
T
Y
S
A
L
DH
AA
S
C
LAN
WMLAK
GI
E
S
GD
RI
A
F
QL
P
G
WC
EF
TVI
Y
L
A
C
LK
T
GA
VS
VP
L
L
P
S
WR
E
A
EL
V
W
V
L
NKC
QA
KMFFAP
T
----
LFK
Q
T
R
P
VD
LI
LPL
Q
NQ
L
P
QL
QQ
I
VGV
D
KLAP
A
T
SS
L
-
S
LS
Q
I
L
A
D
----------
N
T
P
L
T
--
TA
I
T
THG
DE
L
A
AV
LFTSGT
E
G
L
PKGV
ML
THNN
ILA
S
E
R
A
Y
CAR
L
N
LT
W
QDV
FM
MPA
P
L
G
H
ATGFLH
G
VT
AP
-----
FL
I
GA
R
S
VL
LDIF
TP
D
AC
LA
L
L
E
Q
Q
R
C
T
C
M
LGA
T
P
F
V
-
Y
D
L
L
N
L
L
E--
K
QP
A
D
L
SA
L
R
F
F
L
C
GG
TT
IP
KKV-
AR
E
C
Q
Q
R
G
I
K
LL
S
VYG
S
TE
SSP
HA
V
VN
---
LDDP
LP
R
----
F
M
HT
D
GY
AA
-
AGV
E
IK
V
V
DD
AHK
T
LP
P
G
C
E
GE
EAS
R
---
GP
NV
F
M
GYF
DE
P
E
L
TA
R
ALD
E
E
GWY
Y
SGDL
CRM
DE
A
GYI
KIT
GR
K
KD
I
I
V
RGGENIS
SR
E
V
E
D
ILL
Q
HPKI
H
DA
C
VV
A
M
P
DE
RL
GE
R
SCAYVVLK
A
P
H
HS
LS
L
EEV
V
V
F
FS
RK
R
V
AK
Y
K
Y
P
EH
I
V
VI
E
K
LPRT
V
SGKI
Q
K
F
L
LR
KDIMR
RLTQDVCEEIE
fig|670897.3.peg.2536
Escherichia coli 2362-75
MKVTLTFNEQRRAAYR
QQ
G
L
W
G
D
AS
LAD
YW
-
QQ
TA
R
A
MP
D
K
IAVVD
NH
G
AT
Y
T
Y
S
A
L
DH
AA
S
C
LA
Y
WMLAK
GI
E
S
GD
RI
A
F
QL
P
G
WC
EF
TVI
Y
L
A
C
LK
T
GA
VS
VP
L
L
P
S
WR
E
A
EL
V
W
V
L
NKC
QA
KMFFAP
T
----
LFK
Q
T
R
P
VD
LI
LPL
Q
NQ
L
P
QL
QQ
I
VGV
D
KLSP
A
T
SS
L
-
S
LS
Q
I
L
A
D
----------
N
T
P
L
T
--
TA
I
T
THG
DE
L
A
AV
LFTSGT
E
G
L
PKGV
ML
THNN
ILA
S
E
R
A
Y
CAR
L
N
LT
W
QDV
FM
MPA
P
L
G
H
ATGFLH
G
VT
AP
-----
FL
I
GA
R
S
VL
LDIF
TP
D
AC
LA
L
L
E
Q
Q
R
C
T
C
M
LGA
T
P
F
V
-
Y
D
L
L
N
L
L
E--
K
QP
A
D
L
SA
L
R
F
F
L
C
GG
TT
IP
KKV-
AR
E
C
Q
Q
R
G
I
K
LL
S
VYG
S
TE
SSP
HA
V
VN
---
LDDP
LP
R
----
F
M
HT
D
GY
AA
-
AGV
E
IK
V
V
DD
ARK
T
LP
P
G
C
E
GE
EAS
R
---
GP
NV
F
M
GYF
DE
P
E
L
TA
R
ALD
E
E
GWY
Y
SGDL
CRM
DE
A
GYI
KIT
GR
K
KD
I
I
V
RGGENIS
SR
E
V
E
D
ILL
Q
HPKI
H
DA
C
VV
A
M
P
DE
RL
GE
R
SCAYVVLK
A
P
H
HS
LS
L
EEV
V
A
F
FS
RK
R
V
AK
Y
K
Y
P
EH
I
V
VI
E
K
LPRT
V
SGKI
Q
K
F
L
LR
KDIMR
RLTQDVCEEIE
fig|656414.3.peg.2020
Escherichia coli H736
MKVTLTFNEQRRAAYR
QQ
G
L
W
G
D
AS
LAD
YW
-
QQ
TA
R
A
MP
D
K
IAVVD
NH
G
AS
Y
T
Y
S
A
L
DH
AA
S
C
LAN
WMLAK
GI
E
S
GD
RI
A
F
QL
P
G
WC
EF
TVI
Y
L
A
C
LKIGA
VS
VP
L
L
P
S
WR
E
A
EL
V
W
V
L
NKC
QA
KMFFAP
T
----
LFK
Q
T
R
P
VD
LI
LPL
Q
NQ
L
P
QL
QQ
I
VGV
D
KLAP
A
T
SS
L
-
S
LS
Q
I
I
A
D
----------
N
T
S
L
T
--
TA
I
T
THG
DE
L
A
AV
LFTSGT
E
G
L
PKGV
ML
THNN
ILA
S
E
R
A
Y
CAR
L
N
LT
W
QDV
FM
MPA
P
L
G
H
ATGFLH
G
VT
AP
-----
FL
I
GA
R
S
VL
LDIF
TP
D
AC
LA
L
L
E
Q
Q
R
C
T
C
M
LGA
T
P
F
V
-
Y
D
L
L
N
V
L
E--
K
QP
A
D
L
SA
L
R
F
F
L
C
GG
TT
IP
KKV-
AR
E
C
Q
Q
R
G
I
K
LL
S
VYG
S
TE
SSP
HA
V
VN
---
LDDP
LS
H
----
F
M
HT
D
GY
AA
-
AGV
E
IK
V
V
DD
ARK
T
LP
P
G
C
E
GE
EAS
R
---
GP
NV
F
M
GYF
DE
P
E
L
TA
R
ALD
E
E
GWY
Y
SGDL
CRM
DE
A
GYI
KIT
GR
K
KD
I
I
V
RGGENIS
SR
E
V
E
D
ILL
Q
HPKI
H
DA
C
VV
A
M
S
DE
RL
GE
R
SCAYVVLK
A
P
H
HS
LS
L
EEV
V
A
F
FS
RK
R
V
AK
Y
K
Y
P
EH
I
V
VI
E
K
LPRT
T
SGKI
Q
K
F
L
LR
KDIMR
RLTQDVCEEIE
fig|749540.3.peg.4114
Escherichia coli MS 146-1
MKVTLTFNEQRRAAYR
QQ
G
L
W
G
D
AS
LAD
YW
-
QQ
TA
R
A
MP
D
K
IAVVD
NH
G
AS
Y
T
Y
S
A
L
DH
AA
S
C
LAN
WMLAK
GI
E
S
GD
RI
A
F
QL
P
G
WC
EF
TVI
Y
L
A
C
LKIGA
VS
VP
L
L
P
S
WR
E
A
EL
V
W
V
L
NKC
QA
KMFFAP
T
----
LFK
Q
T
R
P
VD
LI
LPL
Q
NQ
L
P
QL
QQ
I
VGV
D
KLAP
A
T
SS
L
-
S
LS
Q
I
I
A
D
----------
N
T
S
L
T
--
TA
I
T
THG
DE
L
A
AV
LFTSGT
E
G
L
PKGV
ML
THNN
ILA
S
E
R
A
Y
CAR
L
N
LT
W
QDV
FM
MPA
P
L
G
H
ATGFLH
G
VT
AP
-----
FL
I
GA
R
S
VL
LDIF
TP
D
AC
LA
L
L
E
Q
Q
R
C
T
C
M
LGA
T
P
F
V
-
Y
D
L
L
N
V
L
E--
K
QP
A
D
L
SA
L
R
F
F
L
C
GG
TT
IP
KKV-
AR
E
C
Q
Q
R
G
I
K
LL
S
VYG
S
TE
SSP
HA
V
VN
---
LDDP
LS
H
----
F
M
HT
D
GY
AA
-
AGV
E
IK
V
V
DD
ARK
T
LP
P
G
C
E
GE
EAS
R
---
GP
NV
F
M
GYF
DE
P
E
L
TA
R
ALD
E
E
GWY
Y
SGDL
CRM
DE
A
GYI
KIT
GR
K
KD
I
I
V
RGGENIS
SR
E
V
E
D
ILL
Q
HPKI
H
DA
C
VV
A
M
S
DE
RL
GE
R
SCAYVVLK
A
P
H
HS
LS
L
EEV
V
A
F
FS
RK
R
V
AK
Y
K
Y
P
EH
I
V
VI
E
K
LPRT
T
SGKI
Q
K
F
L
LR
KDIMR
RLTQDVCEEIE
fig|656393.3.peg.2498
Escherichia coli H299
MKVTLTFNEQRRAAYR
QQ
G
L
W
G
D
AS
LAD
YW
-
QQ
TA
R
A
MP
D
K
IAVVD
NH
G
AT
Y
T
Y
S
A
L
DH
AA
S
C
LAN
WMLAK
GI
E
S
GD
RI
A
F
QL
P
G
WC
EF
TVI
Y
L
A
C
LK
T
GA
VS
VP
L
L
P
S
WR
E
A
EL
V
W
V
L
NKC
QA
KMFFAP
T
----
LFK
Q
T
R
P
VD
LI
LPL
Q
NQ
L
P
QL
QQ
I
VGV
D
KLAP
A
T
S
AL
-
S
LS
Q
I
I
A
D
----------
N
T
P
L
T
--
TA
I
T
VHG
DE
L
A
AV
LFTSGT
E
G
L
PKGV
ML
THNN
ILA
S
E
R
A
Y
CAR
L
N
LT
W
QDV
FM
MPA
P
L
G
H
ATGFLH
G
VT
AP
-----
FL
I
GA
R
S
VL
LDIF
TP
A
AC
LA
L
L
E
Q
Q
R
C
T
C
M
LGA
T
P
F
V
-
Y
D
L
L
N
L
L
E--
K
QP
A
D
L
SA
L
R
F
F
L
C
GG
TT
IP
KKV-
AR
E
C
Q
Q
R
G
I
K
LL
S
VYG
S
TE
SSP
HA
V
VN
---
LDDP
LS
R
----
F
IHT
D
GY
AA
-
AGV
E
IK
V
V
DD
ARK
T
LP
P
G
C
E
GE
EAS
R
---
GP
NV
F
M
GYF
DE
P
E
L
TA
R
ALD
E
E
GWY
Y
SGDL
CRM
DE
A
GYI
KIT
GR
K
KD
I
I
V
RGGENIS
SR
E
V
E
D
ILL
Q
HPKI
H
DA
C
VV
A
M
P
DE
RL
GE
R
SCAYVVLK
A
P
H
HS
LS
L
E
D
V
V
A
F
FS
RK
R
V
AK
Y
K
Y
P
EH
I
V
VI
E
K
LPRT
A
SGKI
Q
K
F
L
LR
KDIMR
RLTQDVCEEIE
fig|316401.4.peg.1989
Escherichia coli ETEC H10407
MKVTLTFNEQRRAAYR
QQ
G
L
W
G
D
AS
LAD
YW
-
QQ
TA
R
A
MP
D
K
IAVVD
NH
G
AS
Y
T
Y
S
A
L
DH
AA
S
C
LAN
WMLAK
GI
E
S
GD
RI
A
F
QL
P
G
WC
EF
TVI
Y
L
A
C
LKIGA
VS
VP
L
L
P
S
WR
E
A
EL
V
W
V
L
NKC
QA
KMFFAP
T
----
LFK
Q
T
R
P
VD
LI
LPL
Q
NQ
L
P
QL
QQ
I
VGV
D
KLAP
A
T
SS
L
-
S
LS
Q
I
I
A
D
----------
N
T
S
L
T
--
TA
I
T
THG
DE
L
A
AV
LFTSGT
E
G
L
PKGV
ML
THNN
ILA
S
E
R
A
Y
CAR
L
N
LT
W
QDV
FM
MPA
P
L
G
H
ATGFLH
G
VT
AP
-----
FL
I
GA
R
S
VL
LDIF
TP
D
AC
LA
L
L
E
Q
Q
R
C
T
C
M
LGA
T
P
F
V
-
Y
D
L
L
N
V
L
E--
K
QP
A
D
L
SA
L
R
F
F
L
C
GG
TT
IP
KKV-
AR
E
C
Q
Q
R
G
I
K
LL
S
VYG
S
TE
SSP
HA
V
VN
---
LDDP
LS
R
----
F
M
HT
D
GY
AA
-
AGV
E
IK
V
V
DD
ARK
T
LP
P
G
C
E
GE
EAS
R
---
GP
NV
F
M
GYF
DE
P
E
L
TA
R
ALD
E
E
GWY
Y
SGDL
CRM
DE
A
GYI
KIT
GR
K
KD
I
I
V
RGGENIS
SR
E
V
E
D
ILL
Q
HPKI
H
DA
C
VV
A
M
S
DE
RL
GE
R
SCAYVVLK
A
P
H
HS
LS
L
EEV
V
A
F
FS
RK
R
V
AK
Y
K
Y
P
EH
I
V
VI
E
K
LP
L
T
T
SGKI
Q
K
F
L
LR
KDIMR
RLTQDVCEEIE
fig|358709.5.peg.3200
Escherichia coli 101-1 (19-566/566)
MKVTLTFNEQRRAAYR
QQ
G
L
W
G
D
AS
LAD
YW
-
QQ
TA
R
A
MP
D
K
IAVVD
NH
G
AT
Y
T
Y
S
A
L
DH
AA
S
C
LAN
WMLAK
GI
E
S
GD
RI
A
F
QL
P
G
WC
EF
TVI
Y
L
A
C
LKIGA
VS
VP
L
L
P
S
WR
E
A
EL
V
W
V
L
NKC
QA
KMFFAP
T
----
LFK
Q
T
R
P
VD
LI
LPL
Q
NQ
L
P
QL
QQ
I
VGV
D
KLAP
A
T
SS
L
-
S
LS
Q
I
I
A
D
----------
N
I
P
L
T
--
TA
I
T
THG
DE
L
A
AV
LFTSGT
E
G
L
PKGV
ML
THNN
ILA
S
E
R
A
Y
CAR
L
N
LT
W
L
DV
FM
MPA
P
L
G
H
ATGFLH
G
VT
AP
-----
FL
I
GA
R
S
VL
LDIF
TP
D
AC
LA
L
L
E
Q
Q
R
C
T
C
M
LGA
T
P
F
V
-
Y
D
L
L
N
L
L
E--
K
QP
A
D
L
SA
L
R
F
F
L
C
GG
TT
IP
KKV-
AR
E
C
Q
Q
L
G
I
K
LL
S
VYG
S
TE
SSP
HA
V
VN
---
LDDP
LS
R
----
F
M
HT
D
GY
AA
-
AGV
E
IK
V
V
N
D
ARK
T
LP
P
G
C
E
GE
EAS
R
---
GP
NV
F
M
GYF
DE
P
E
L
TA
R
ALD
E
E
GWY
Y
SGDL
CRM
DE
A
GYI
KIT
GR
K
KD
I
I
V
RGGENIS
SR
E
V
E
D
ILL
Q
HPKI
H
DA
C
VV
A
M
P
DE
RL
GE
R
SCAYVVLK
A
P
H
HS
LS
L
EEV
V
A
F
FS
RK
R
V
AK
Y
K
Y
P
EH
I
V
VI
E
K
LPRT
A
SGKI
Q
K
F
L
LR
KDIMR
RLTQD
A
CEEIE
fig|413997.3.peg.1747
Escherichia coli B str. REL606 (19-566/566)
MKVTLTFNEQRRAAYR
QQ
G
L
W
G
D
AS
LAD
YW
-
QQ
TA
R
A
MP
D
K
IAVVD
NH
G
AT
Y
T
Y
S
A
L
DH
AA
S
C
LAN
WMLAK
GI
E
S
GD
RI
A
F
QL
P
G
WC
EF
TVI
Y
L
A
C
LKIGA
VS
VP
L
L
P
S
WR
E
A
EL
V
W
V
L
NKC
QA
KMFFAP
T
----
LFK
Q
T
R
P
VD
LI
LPL
Q
NQ
L
P
QL
QQ
I
VGV
D
KLAP
A
T
SS
L
-
S
LS
Q
I
I
A
D
----------
N
I
P
L
T
--
TA
I
T
THG
DE
L
A
AV
LFTSGT
E
G
L
PKGV
ML
THNN
ILA
S
E
R
A
Y
CAR
L
N
LT
W
L
DV
FM
MPA
P
L
G
H
ATGFLH
G
VT
AP
-----
FL
I
GA
R
S
VL
LDIF
TP
D
AC
LA
L
L
E
Q
Q
R
C
T
C
M
LGA
T
P
F
V
-
Y
D
L
L
N
L
L
E--
K
QP
A
D
L
SA
L
R
F
F
L
C
GG
TT
IP
KKV-
AR
E
C
Q
Q
L
G
I
K
LL
S
VYG
S
TE
SSP
HA
V
VN
---
LDDP
LS
R
----
F
M
HT
D
GY
AA
-
AGV
E
IK
V
V
N
D
ARK
T
LP
P
G
C
E
GE
EAS
R
---
GP
NV
F
M
GYF
DE
P
E
L
TA
R
ALD
E
E
GWY
Y
SGDL
CRM
DE
A
GYI
KIT
GR
K
KD
I
I
V
RGGENIS
SR
E
V
E
D
ILL
Q
HPKI
H
DA
C
VV
A
M
P
DE
RL
GE
R
SCAYVVLK
A
P
H
HS
LS
L
EEV
V
A
F
FS
RK
R
V
AK
Y
K
Y
P
EH
I
V
VI
E
K
LPRT
A
SGKI
Q
K
F
L
LR
KDIMR
RLTQD
A
CEEIE
fig|511693.5.peg.1775
Escherichia coli BL21 (19-566/566)
MKVTLTFNEQRRAAYR
QQ
G
L
W
G
D
AS
LAD
YW
-
QQ
TA
R
A
MP
D
K
IAVVD
NH
G
AT
Y
T
Y
S
A
L
DH
AA
S
C
LAN
WMLAK
GI
E
S
GD
RI
A
F
QL
P
G
WC
EF
TVI
Y
L
A
C
LKIGA
VS
VP
L
L
P
S
WR
E
A
EL
V
W
V
L
NKC
QA
KMFFAP
T
----
LFK
Q
T
R
P
VD
LI
LPL
Q
NQ
L
P
QL
QQ
I
VGV
D
KLAP
A
T
SS
L
-
S
LS
Q
I
I
A
D
----------
N
I
P
L
T
--
TA
I
T
THG
DE
L
A
AV
LFTSGT
E
G
L
PKGV
ML
THNN
ILA
S
E
R
A
Y
CAR
L
N
LT
W
L
DV
FM
MPA
P
L
G
H
ATGFLH
G
VT
AP
-----
FL
I
GA
R
S
VL
LDIF
TP
D
AC
LA
L
L
E
Q
Q
R
C
T
C
M
LGA
T
P
F
V
-
Y
D
L
L
N
L
L
E--
K
QP
A
D
L
SA
L
R
F
F
L
C
GG
TT
IP
KKV-
AR
E
C
Q
Q
L
G
I
K
LL
S
VYG
S
TE
SSP
HA
V
VN
---
LDDP
LS
R
----
F
M
HT
D
GY
AA
-
AGV
E
IK
V
V
N
D
ARK
T
LP
P
G
C
E
GE
EAS
R
---
GP
NV
F
M
GYF
DE
P
E
L
TA
R
ALD
E
E
GWY
Y
SGDL
CRM
DE
A
GYI
KIT
GR
K
KD
I
I
V
RGGENIS
SR
E
V
E
D
ILL
Q
HPKI
H
DA
C
VV
A
M
P
DE
RL
GE
R
SCAYVVLK
A
P
H
HS
LS
L
EEV
V
A
F
FS
RK
R
V
AK
Y
K
Y
P
EH
I
V
VI
E
K
LPRT
A
SGKI
Q
K
F
L
LR
KDIMR
RLTQD
A
CEEIE
fig|469008.4.peg.2003
Escherichia coli BL21(DE3) (19-566/566)
MKVTLTFNEQRRAAYR
QQ
G
L
W
G
D
AS
LAD
YW
-
QQ
TA
R
A
MP
D
K
IAVVD
NH
G
AT
Y
T
Y
S
A
L
DH
AA
S
C
LAN
WMLAK
GI
E
S
GD
RI
A
F
QL
P
G
WC
EF
TVI
Y
L
A
C
LKIGA
VS
VP
L
L
P
S
WR
E
A
EL
V
W
V
L
NKC
QA
KMFFAP
T
----
LFK
Q
T
R
P
VD
LI
LPL
Q
NQ
L
P
QL
QQ
I
VGV
D
KLAP
A
T
SS
L
-
S
LS
Q
I
I
A
D
----------
N
I
P
L
T
--
TA
I
T
THG
DE
L
A
AV
LFTSGT
E
G
L
PKGV
ML
THNN
ILA
S
E
R
A
Y
CAR
L
N
LT
W
L
DV
FM
MPA
P
L
G
H
ATGFLH
G
VT
AP
-----
FL
I
GA
R
S
VL
LDIF
TP
D
AC
LA
L
L
E
Q
Q
R
C
T
C
M
LGA
T
P
F
V
-
Y
D
L
L
N
L
L
E--
K
QP
A
D
L
SA
L
R
F
F
L
C
GG
TT
IP
KKV-
AR
E
C
Q
Q
L
G
I
K
LL
S
VYG
S
TE
SSP
HA
V
VN
---
LDDP
LS
R
----
F
M
HT
D
GY
AA
-
AGV
E
IK
V
V
N
D
ARK
T
LP
P
G
C
E
GE
EAS
R
---
GP
NV
F
M
GYF
DE
P
E
L
TA
R
ALD
E
E
GWY
Y
SGDL
CRM
DE
A
GYI
KIT
GR
K
KD
I
I
V
RGGENIS
SR
E
V
E
D
ILL
Q
HPKI
H
DA
C
VV
A
M
P
DE
RL
GE
R
SCAYVVLK
A
P
H
HS
LS
L
EEV
V
A
F
FS
RK
R
V
AK
Y
K
Y
P
EH
I
V
VI
E
K
LPRT
A
SGKI
Q
K
F
L
LR
KDIMR
RLTQD
A
CEEIE
fig|344601.5.peg.4014
Escherichia coli B171
MKVTLTFNEQRRAAYR
QQ
G
L
W
G
D
AS
LAD
YW
-
QQ
TA
R
A
MP
D
K
IAVVD
NH
G
AS
Y
T
Y
S
A
L
DH
AA
S
C
LAN
WMLAK
GI
E
S
GD
RI
A
F
QL
P
G
WC
EF
TVI
Y
L
A
C
LKIGA
VS
VP
L
L
P
S
WR
E
A
EL
V
W
V
L
NKC
QA
KMFFAP
T
----
LFK
Q
T
R
P
VD
LI
LPL
Q
NQ
L
P
QL
QQ
I
VGV
D
KLAP
A
T
SS
L
-
S
LS
Q
I
I
A
D
----------
N
T
S
L
T
--
TA
I
T
THG
DE
L
A
AV
LFTSGT
E
G
L
PKGV
ML
THNN
ILA
S
E
R
A
Y
CVR
L
N
LT
W
QDV
FM
MPA
P
L
G
H
ATGFLH
G
VT
AP
-----
FL
I
GA
R
S
VL
LDIF
TP
D
AC
LA
L
L
E
Q
Q
R
C
T
C
M
LGA
T
P
F
V
-
Y
D
L
L
N
V
L
E--
K
QP
A
D
L
SA
L
R
F
F
L
C
GG
TT
IP
KKV-
AR
E
C
Q
Q
L
G
I
K
LL
S
VYG
S
TE
SSP
HA
V
VN
---
LDDP
LS
R
----
F
M
HT
D
GY
AA
-
AGV
E
IK
V
V
DD
ARK
T
LP
P
G
C
E
GE
EAS
R
---
GP
NV
F
M
GYF
DE
P
E
L
TA
R
ALD
E
E
GWY
Y
SGDL
CRM
DE
A
GYI
KIT
GR
K
KD
I
I
V
RGGENIS
SR
E
V
E
D
ILL
Q
HPKI
H
DA
C
VV
A
M
P
DE
RL
GE
R
SCAYVVLK
A
P
H
HS
LS
L
EEV
V
A
F
FS
RK
R
V
AK
Y
K
Y
P
EH
I
V
VI
E
K
LPRT
A
SGKI
Q
K
C
L
LR
KDIMR
RLTQDVCEEIE
fig|344601.3.peg.3833
Escherichia coli B171 (19-566/566)
MKVTLTFNEQRRAAYR
QQ
G
L
W
G
D
AS
LAD
YW
-
QQ
TA
R
A
MP
D
K
IAVVD
NH
G
AS
Y
T
Y
S
A
L
DH
AA
S
C
LAN
WMLAK
GI
E
S
GD
RI
A
F
QL
P
G
WC
EF
TVI
Y
L
A
C
LKIGA
VS
VP
L
L
P
S
WR
E
A
EL
V
W
V
L
NKC
QA
KMFFAP
T
----
LFK
Q
T
R
P
VD
LI
LPL
Q
NQ
L
P
QL
QQ
I
VGV
D
KLAP
A
T
SS
L
-
S
LS
Q
I
I
A
D
----------
N
T
S
L
T
--
TA
I
T
THG
DE
L
A
AV
LFTSGT
E
G
L
PKGV
ML
THNN
ILA
S
E
R
A
Y
CVR
L
N
LT
W
QDV
FM
MPA
P
L
G
H
ATGFLH
G
VT
AP
-----
FL
I
GA
R
S
VL
LDIF
TP
D
AC
LA
L
L
E
Q
Q
R
C
T
C
M
LGA
T
P
F
V
-
Y
D
L
L
N
V
L
E--
K
QP
A
D
L
SA
L
R
F
F
L
C
GG
TT
IP
KKV-
AR
E
C
Q
Q
L
G
I
K
LL
S
VYG
S
TE
SSP
HA
V
VN
---
LDDP
LS
R
----
F
M
HT
D
GY
AA
-
AGV
E
IK
V
V
DD
ARK
T
LP
P
G
C
E
GE
EAS
R
---
GP
NV
F
M
GYF
DE
P
E
L
TA
R
ALD
E
E
GWY
Y
SGDL
CRM
DE
A
GYI
KIT
GR
K
KD
I
I
V
RGGENIS
SR
E
V
E
D
ILL
Q
HPKI
H
DA
C
VV
A
M
P
DE
RL
GE
R
SCAYVVLK
A
P
H
HS
LS
L
EEV
V
A
F
FS
RK
R
V
AK
Y
K
Y
P
EH
I
V
VI
E
K
LPRT
A
SGKI
Q
K
C
L
LR
KDIMR
RLTQDVCEEIE
fig|685038.3.peg.1719
Escherichia coli O83:H1 str. NRG 857C
MKVTLTFNEQRRAAYR
QQ
G
L
W
G
D
AS
LAD
YW
-
QQ
TA
R
A
MP
D
K
IAVVD
NH
G
AT
Y
T
Y
S
A
L
DH
AA
S
C
LAN
WMLAK
GI
E
S
GD
RI
A
F
QL
P
G
WC
EF
TVI
Y
L
A
C
LK
T
GA
VS
VP
L
L
P
S
WR
E
A
EL
V
W
V
L
NKC
QA
KMFFAA
T
----
LFK
Q
T
R
P
VD
LI
LPL
Q
NQ
L
P
QL
QQ
I
VGV
D
KLAP
A
T
SS
L
-
S
LS
Q
I
L
A
D
----------
N
T
P
L
T
--
TA
I
T
THA
DE
L
A
AV
LFTSGT
E
G
L
PKGV
ML
THNN
ILA
S
E
R
A
Y
CAR
L
N
LT
W
QDV
FM
MPA
P
L
G
H
ATGFLH
G
VT
AP
-----
FL
I
GA
R
S
VL
LDIF
TP
D
AC
LA
L
L
E
Q
Q
R
C
T
C
M
LGA
T
P
F
V
-
Y
D
L
L
N
L
L
E--
K
QP
A
D
L
SA
L
R
F
F
L
C
GG
TT
IP
KKV-
AR
E
C
Q
Q
R
G
I
K
LL
S
VYG
S
TE
SSP
HA
V
VN
---
LDDP
LP
R
----
F
M
HT
D
GY
AA
-
AGV
E
IK
V
V
DD
ARK
T
LP
P
G
C
E
GE
EAS
R
---
GP
NV
F
M
GYF
DE
P
E
L
TA
R
ALD
E
E
GWY
Y
SGDL
CRM
DE
A
GYI
KIT
GR
K
KD
I
I
V
RGGENIS
SR
E
V
E
D
ILL
Q
HPKI
H
DA
C
VV
A
M
P
DE
RL
GE
R
SCAYVVLK
A
P
H
HS
LS
L
EEV
V
A
F
FS
RK
R
V
AK
Y
K
Y
P
EH
I
V
VI
E
K
LPRT
V
SGKI
Q
K
F
L
LR
KDIMR
RLTQDVCEEIE
fig|216592.3.peg.1942
Escherichia coli 042
MKVTLTFNEQRRAAYR
QQ
G
L
W
G
D
AS
LAD
YW
-
QQ
TA
R
A
MP
D
K
IAVVD
NH
G
AS
Y
T
Y
S
A
L
DH
AA
S
C
LAN
WMLAK
GI
E
S
GD
RI
A
F
QL
P
G
WC
EF
TVI
Y
L
A
C
LKIGA
VS
VP
L
L
P
S
WR
E
A
EL
V
W
V
L
NKC
QA
KMFFAP
T
----
LFK
Q
T
R
P
VD
LI
LPL
Q
NQ
L
P
QL
QQ
L
VGV
D
KLAP
A
T
S
AL
-
S
LS
Q
I
I
A
D
----------
N
T
P
L
T
--
TA
I
T
VHG
DE
L
A
AV
LFTSGT
E
G
L
PKGV
ML
THNN
ILA
S
E
R
A
Y
CAR
L
N
LT
W
QDV
FM
MPA
P
L
G
H
ATGFLH
G
VT
AP
-----
FL
I
GA
R
S
VL
LDIF
TP
D
AC
LA
L
L
E
Q
Q
R
C
T
C
M
LGA
T
P
F
V
-
Y
D
L
L
N
L
L
E--
K
QP
A
D
L
SA
L
R
F
F
L
C
GG
TT
IP
KKV-
AR
E
C
Q
Q
R
G
I
K
LL
S
VYG
S
TE
SSP
HA
V
VN
---
LDDP
LS
R
----
F
M
HT
D
GY
AA
-
AGV
E
IK
V
V
DD
ARK
T
LP
P
G
C
E
GE
EAS
R
---
GP
NV
F
M
GYF
DE
P
E
L
TA
R
ALD
E
E
GWY
Y
SGDL
CCM
DE
A
GYI
KIT
GR
K
KD
I
I
V
RGGENIS
SR
E
V
E
D
ILL
Q
HPKI
H
DA
C
VV
A
M
P
DE
RL
GE
R
SCAYVVLK
A
P
H
HS
LS
L
EEV
V
A
F
FS
RK
R
V
AK
Y
K
Y
P
EH
I
V
VI
E
K
LPRT
A
SGKI
Q
K
F
L
LR
KDIM
L
RLTQD
A
CEEIE
fig|216592.1.peg.1236
Escherichia coli 042 (19-566/566)
MKVTLTFNEQRRAAYR
QQ
G
L
W
G
D
AS
LAD
YW
-
QQ
TA
R
A
MP
D
K
IAVVD
NH
G
AS
Y
T
Y
S
A
L
DH
AA
S
C
LAN
WMLAK
GI
E
S
GD
RI
A
F
QL
P
G
WC
EF
TVI
Y
L
A
C
LKIGA
VS
VP
L
L
P
S
WR
E
A
EL
V
W
V
L
NKC
QA
KMFFAP
T
----
LFK
Q
T
R
P
VD
LI
LPL
Q
NQ
L
P
QL
QQ
L
VGV
D
KLAP
A
T
S
AL
-
S
LS
Q
I
I
A
D
----------
N
T
P
L
T
--
TA
I
T
VHG
DE
L
A
AV
LFTSGT
E
G
L
PKGV
ML
THNN
ILA
S
E
R
A
Y
CAR
L
N
LT
W
QDV
FM
MPA
P
L
G
H
ATGFLH
G
VT
AP
-----
FL
I
GA
R
S
VL
LDIF
TP
D
AC
LA
L
L
E
Q
Q
R
C
T
C
M
LGA
T
P
F
V
-
Y
D
L
L
N
L
L
E--
K
QP
A
D
L
SA
L
R
F
F
L
C
GG
TT
IP
KKV-
AR
E
C
Q
Q
R
G
I
K
LL
S
VYG
S
TE
SSP
HA
V
VN
---
LDDP
LS
R
----
F
M
HT
D
GY
AA
-
AGV
E
IK
V
V
DD
ARK
T
LP
P
G
C
E
GE
EAS
R
---
GP
NV
F
M
GYF
DE
P
E
L
TA
R
ALD
E
E
GWY
Y
SGDL
CCM
DE
A
GYI
KIT
GR
K
KD
I
I
V
RGGENIS
SR
E
V
E
D
ILL
Q
HPKI
H
DA
C
VV
A
M
P
DE
RL
GE
R
SCAYVVLK
A
P
H
HS
LS
L
EEV
V
A
F
FS
RK
R
V
AK
Y
K
Y
P
EH
I
V
VI
E
K
LPRT
A
SGKI
Q
K
F
L
LR
KDIM
L
RLTQD
A
CEEIE
fig|656444.3.peg.2605
Escherichia coli TA280
MKVTLTFNEQRRAAYR
QQ
G
L
W
G
D
AS
L
T
D
YW
-
QQ
TA
R
A
MP
D
K
IAVVD
NH
G
AS
Y
T
Y
S
A
L
DH
AA
S
C
LAN
WMLTK
GI
E
S
GD
RI
A
F
QL
P
G
WC
EF
TVI
Y
L
A
C
LKIGA
VS
VP
L
L
P
S
WR
E
A
EL
V
W
V
L
NKC
QA
KMFFAP
T
----
LFK
Q
T
R
P
VD
LI
LPL
Q
NQ
L
P
QL
QQ
I
VGV
D
KLAP
A
T
SS
L
-
S
LS
Q
I
I
A
D
----------
N
T
P
L
T
--
TA
I
T
VHG
DE
L
A
AV
LFTSGT
E
G
L
PKGV
ML
THNN
ILA
S
E
R
A
Y
CAR
L
N
LT
W
QDV
FM
MPA
P
L
G
H
ATGFLH
G
VT
AP
-----
FL
I
GA
R
S
VL
LDIF
TP
D
AC
LA
L
L
E
Q
Q
R
C
T
C
M
LGA
T
P
F
V
-
Y
D
L
L
N
L
L
E--
K
QP
A
D
L
SA
L
R
F
F
L
C
GG
TT
IP
KKV-
AR
E
C
Q
Q
R
G
I
K
LL
S
VYG
S
TE
SSP
HA
V
VN
---
LDDP
LS
R
----
F
M
HT
D
GY
AA
-
AGV
E
IK
V
V
DD
ARK
T
LP
P
G
C
E
GE
EAS
R
---
GP
NV
F
M
GYF
DE
P
E
L
TA
R
ALD
E
E
GWY
Y
SGDL
CRM
DE
A
GYI
KIT
GR
K
KD
I
I
V
RGGENIS
SR
E
V
E
D
ILL
Q
HPKI
H
DA
C
VV
A
M
P
DE
RL
S
E
R
SCAYVVLK
A
P
H
HS
LS
L
E
D
V
V
T
F
FS
RK
R
V
AK
Y
K
Y
P
EH
I
V
VI
E
K
LPRT
A
SGKI
Q
K
F
L
LR
KDIM
L
RLTQDVCEEIE
fig|550676.3.peg.2009
Escherichia coli B185 (1-545/546)
MKVTLTFNEQRRAAYR
QQ
G
L
W
G
D
AS
LAD
YW
-
QQ
TA
R
A
MP
D
K
IAVVD
NH
G
AS
Y
T
Y
S
A
L
DH
T
A
S
C
LAN
WMLAK
GI
E
S
GD
RI
A
F
QL
P
G
WC
EF
TVI
Y
L
A
C
LKIGA
VS
VP
L
L
P
S
WR
E
A
EL
V
W
V
L
NKC
QA
KMFFAP
T
----
LFK
Q
T
R
P
VD
LI
LPL
Q
NQ
L
P
QL
QQ
I
VGV
D
KLAP
A
T
SS
L
-
S
LS
Q
I
I
A
D
----------
N
T
P
L
T
--
TA
I
T
THG
DE
L
A
AV
LFTSGT
E
G
L
PKGV
ML
THNN
ILA
S
E
R
A
Y
CAR
L
N
LT
W
QDV
FM
MPA
P
L
G
H
ATGFLH
G
VT
AP
-----
FL
I
GA
R
S
VL
LDIF
TP
D
AC
LA
L
L
E
Q
Q
R
C
T
C
M
LGA
T
P
F
V
-
Y
D
L
L
N
L
L
E--
K
QP
A
D
L
SA
L
R
F
F
L
C
GG
TT
IP
KKV-
AR
E
C
Q
Q
R
G
I
K
LL
S
VYG
S
TE
SSP
HA
V
VN
---
LDDP
LS
R
----
F
M
HT
D
GY
AA
-
AGV
E
IK
V
V
DD
ARK
T
LP
P
G
C
E
GE
EAS
R
---
GP
NV
F
M
GYF
DE
P
E
L
TA
R
ALD
E
E
GWY
Y
SGDL
CRM
DE
A
GYI
KIT
GR
K
KD
I
I
V
RGGENIS
SR
E
V
E
D
ILL
Q
HPKI
H
DA
C
VV
A
M
P
DE
RL
GE
R
SCAYVVLK
A
P
H
HS
LS
L
EEV
V
A
F
FS
RK
R
V
AK
Y
K
Y
P
EH
I
V
VI
E
K
LPRT
A
SGKI
Q
K
F
L
LR
KDI
VQ
RL
E
Q
SCV
E
fig|749527.3.peg.3506
Escherichia coli MS 21-1 (1-545/546)
MKVTLTFNEQRRAAYR
QQ
G
L
W
G
D
AS
LAD
YW
-
QQ
TA
R
A
MP
D
K
IAVVD
NH
G
AT
Y
T
Y
S
A
L
DH
AA
S
C
LAN
WMLAK
GI
E
S
GD
RI
A
F
QL
P
G
WC
EF
TVI
Y
L
A
C
LK
T
GA
VS
VP
L
L
P
S
WR
E
A
EL
V
W
V
L
NKC
QA
KMFFAP
T
----
LFK
Q
T
R
P
VD
LI
LPL
Q
NQ
L
P
QL
QQ
I
VGV
D
KLAP
A
T
SS
L
-
S
LS
Q
I
I
A
D
----------
N
T
P
L
T
--
TA
I
T
VHG
DE
L
A
AV
LFTSGT
E
G
L
PKGV
ML
THNN
ILA
S
E
R
A
Y
CAR
L
N
LT
W
QDV
FM
MPA
P
L
G
H
ATGFLH
G
VT
AP
-----
FL
I
GA
R
S
VL
LDIF
TP
A
AC
LA
L
L
E
Q
Q
R
C
T
C
M
LGA
T
P
F
V
-
Y
D
L
L
N
L
L
E--
K
QP
A
D
L
SA
L
R
F
F
L
C
GG
TT
IP
KKV-
AR
E
C
Q
Q
R
G
I
K
LL
S
VYG
S
TE
SSP
HA
V
VN
---
LDDP
LS
R
----
F
M
HT
D
GY
AA
-
AGV
E
IK
V
V
DD
ARK
S
LP
P
G
C
E
GE
EAS
R
---
GP
NV
F
M
GYF
DE
P
E
L
TA
R
ALD
E
E
GWY
Y
SGDL
CRM
DE
A
GYI
KIT
GR
K
KD
I
I
V
RGGENIS
SR
E
V
E
D
ILL
Q
HPKI
H
DA
C
VV
A
M
P
DE
RL
GE
R
SCAYVVLK
A
P
H
HS
LS
L
E
D
V
V
A
F
FS
RK
R
V
AK
Y
K
Y
P
EH
I
V
VI
E
K
LPRT
A
SGKI
Q
K
F
L
LR
KDI
LQ
RL
E
Q
TCV
E
fig|439855.10.peg.1653
Escherichia coli SMS-3-5 (1-545/546)
MKVTLTFNEQRRAAYR
QQ
G
L
W
G
D
AS
LAD
YW
-
QQ
TA
R
A
MP
D
K
IAVVD
NH
G
AS
Y
T
Y
S
A
L
DH
AA
S
C
LAN
WMLTK
GI
E
S
GD
RI
A
F
QL
P
G
WC
EF
TVI
Y
L
A
C
LKIGA
VS
VP
L
L
P
S
WR
E
A
EL
V
W
V
L
NKC
QA
KMFFAP
T
----
LFK
Q
T
R
P
VD
LI
LPL
Q
NQ
L
P
QL
QQ
I
VGV
D
KLAP
A
T
SS
L
-
S
LS
Q
I
L
A
D
----------
N
T
P
L
T
--
TA
I
T
THG
DE
L
A
AV
LFTSGT
E
G
L
PKGV
ML
THNN
ILA
S
E
R
A
Y
CAR
L
N
LT
W
QDV
FM
MPA
P
L
G
H
ATGFLH
G
VT
AP
-----
FL
I
GA
R
S
VL
LDIF
TP
A
AC
LA
L
L
E
Q
Q
R
C
T
C
M
LGA
T
P
F
V
-
Y
D
L
L
N
L
L
E--
K
QP
A
D
L
SA
L
R
F
F
L
C
GG
TT
IP
KKV-
AR
E
C
Q
Q
R
G
I
K
LL
S
VYG
S
TE
SSP
HA
V
VN
---
LDDP
LS
R
----
F
M
HT
D
GY
AA
-
AGV
E
IK
V
V
D
G
ARK
T
LP
P
G
C
E
GE
EAS
R
---
GP
NV
F
M
GYF
DE
P
E
L
TA
H
ALD
E
E
GWY
Y
SGDL
CRM
DE
A
GYI
KIT
GR
K
KD
I
I
V
RGGENIS
SR
E
V
E
D
ILL
Q
HPKI
H
DA
C
VV
A
M
P
DE
RL
GE
R
SCAYVVLK
A
P
H
HS
LS
L
E
D
V
V
A
F
FS
RK
R
V
AK
Y
K
Y
P
EH
I
V
VI
E
K
LPRT
A
SGKI
Q
K
F
L
LR
KDI
LQ
RL
E
Q
TCV
E
fig|585057.4.peg.1418
Escherichia coli IAI39 (1-545/546)
MKVTLTFNEQRRAAYR
QQ
G
L
W
G
D
AS
LAD
YW
-
QQ
TA
R
A
MP
D
K
IAVVD
NH
G
AS
Y
T
Y
S
A
L
DH
AA
S
C
LAN
WMLTK
GI
E
S
GD
RI
A
F
QL
P
G
WC
EF
TVI
Y
L
A
C
LKIGA
VS
VP
L
L
P
S
WR
E
A
EL
V
W
V
L
NKC
QA
KMFFAP
T
----
LFK
Q
T
R
P
VD
LI
LPL
Q
NQ
L
P
QL
QQ
I
VGV
D
KLAP
A
T
SS
L
-
S
LS
Q
I
I
A
D
----------
N
T
P
L
T
--
TA
I
T
VHG
DE
L
A
AV
LFTSGT
E
G
L
PKGV
ML
THNN
ILA
S
E
R
A
Y
CAR
L
N
LT
W
QDV
FM
MPA
P
L
G
H
ATGFLH
G
VT
AP
-----
FL
I
GA
R
S
VL
LDIF
TP
A
AC
LA
L
L
E
Q
Q
R
C
T
C
M
LGA
T
P
F
V
-
Y
D
L
L
N
L
L
E--
K
QP
A
D
L
SA
L
R
F
L
L
C
GG
TT
IP
KKV-
AR
E
C
Q
Q
R
G
I
K
LL
S
VYG
S
TE
SSP
HA
V
VN
---
L
N
DP
LP
R
----
F
M
HT
D
GY
AA
-
AGV
E
IK
V
V
DD
ARK
T
LP
P
G
C
E
GE
EAS
R
---
GP
NV
F
M
GYF
DE
P
E
L
TA
R
ALD
E
E
GWY
Y
SGDL
CRM
DE
A
GYI
KIT
GR
K
KD
I
I
V
RGGENIS
SR
E
V
E
D
ILL
Q
HPKI
H
DA
C
VV
A
M
P
DE
RL
GE
R
SCAYVVLK
A
P
H
HS
LS
L
EEV
V
A
F
FS
RK
R
V
AK
Y
K
Y
P
EH
I
V
VI
E
K
LPRT
A
SGKI
Q
K
F
L
LR
KDI
LQ
RL
E
Q
TCV
E
fig|585057.6.peg.1418
Escherichia coli IAI39 (1-545/546)
MKVTLTFNEQRRAAYR
QQ
G
L
W
G
D
AS
LAD
YW
-
QQ
TA
R
A
MP
D
K
IAVVD
NH
G
AS
Y
T
Y
S
A
L
DH
AA
S
C
LAN
WMLTK
GI
E
S
GD
RI
A
F
QL
P
G
WC
EF
TVI
Y
L
A
C
LKIGA
VS
VP
L
L
P
S
WR
E
A
EL
V
W
V
L
NKC
QA
KMFFAP
T
----
LFK
Q
T
R
P
VD
LI
LPL
Q
NQ
L
P
QL
QQ
I
VGV
D
KLAP
A
T
SS
L
-
S
LS
Q
I
I
A
D
----------
N
T
P
L
T
--
TA
I
T
VHG
DE
L
A
AV
LFTSGT
E
G
L
PKGV
ML
THNN
ILA
S
E
R
A
Y
CAR
L
N
LT
W
QDV
FM
MPA
P
L
G
H
ATGFLH
G
VT
AP
-----
FL
I
GA
R
S
VL
LDIF
TP
A
AC
LA
L
L
E
Q
Q
R
C
T
C
M
LGA
T
P
F
V
-
Y
D
L
L
N
L
L
E--
K
QP
A
D
L
SA
L
R
F
L
L
C
GG
TT
IP
KKV-
AR
E
C
Q
Q
R
G
I
K
LL
S
VYG
S
TE
SSP
HA
V
VN
---
L
N
DP
LP
R
----
F
M
HT
D
GY
AA
-
AGV
E
IK
V
V
DD
ARK
T
LP
P
G
C
E
GE
EAS
R
---
GP
NV
F
M
GYF
DE
P
E
L
TA
R
ALD
E
E
GWY
Y
SGDL
CRM
DE
A
GYI
KIT
GR
K
KD
I
I
V
RGGENIS
SR
E
V
E
D
ILL
Q
HPKI
H
DA
C
VV
A
M
P
DE
RL
GE
R
SCAYVVLK
A
P
H
HS
LS
L
EEV
V
A
F
FS
RK
R
V
AK
Y
K
Y
P
EH
I
V
VI
E
K
LPRT
A
SGKI
Q
K
F
L
LR
KDI
LQ
RL
E
Q
TCV
E
fig|656417.3.peg.718
Escherichia coli M605 (16-535/536)
YREKG
Y
W
Q
D
LP
L
T
D
IL
-
--
T
R
H
A
AS
DSIAV
I
D
GE
-
RQ
L
SY
R
ELNQAAD
N
LA
C
SLRRQ
GIK
P
G
E
TA
L
V
QL
G
N
VA
E
L
YIT
FFALLK
L
G
V
AP
V
L
A
L
F
S
HQ
R
S
EL
-
-
-
-
---
--
-----N
A
----
YAS
QIEP
AL
LI
ADR
Q
HA
L
F
SG
DD
F
--L
N
KFVA
E
H
SSI
-
R
VV
QL
L
ND
SGEHNLQDAI
N
H
PA
E
DF
TA
T
P
SPA
DE
V
A
YF
QLSG
GTTG
T
PK
LI
PR
THN
D
YYY
S
V
R
R
S
VEI
C
Q
F
T
Q
Q
TR
YL
CAI
PA
A
H
N----Y
A
MS
S
P
GSLGV
FLAG
G
T
V
VL
AADP
SA
T
L
C
FP
LIEK
H
Q
V
N
V
T
ALV
PP
A
V
-
S
L
W
LQ
A
L
AEG
E
SR
A
Q
L
AS
L
K
L
L
Q
V
GG
AR
LS
ATLA
AR
I
P
A
E
I
G
C
Q
L
Q
Q
V
F
GM
A
E
---
-
GLVN
YTR
LDD
S
AE
K
----
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Escherichia coli TA206 (16-535/536)
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Escherichia coli MS 84-1 (16-533/536)
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Escherichia coli O157:H7 str. TW14588 (16-533/536)
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fig|340197.3.peg.2432
Escherichia coli F11 (16-535/536)
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fig|340197.5.peg.2551
Escherichia coli F11 (16-535/536)
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fig|749550.3.peg.4852
Escherichia coli MS 200-1 (16-535/536)
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fig|670888.3.peg.1159
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Escherichia coli O157:H7 EDL933 (16-533/536)
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fig|562.376.peg.1283
Escherichia coli WV_060327 (12-516/517)
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fig|670897.3.peg.1850
Escherichia coli 2362-75 (12-516/517)
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L
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T
GD
T
GYR
DEEG
FF
YFV
D
R
R
CN
M
I
K
RGGEN
V
S
CV
E
L
ENI
IA
T
HPKI
Q
D
I
V
VV
G
I
K
D
S
IR
D
E
A
IK
A
F
VVL
N
E
G
-
ET
LS
E
EE
F
F
C
F
-C
EQ
N
M
AKFK
V
P
SY
L
E
IR
K
D
LPR
N
C
SGKI
I
R
K
N
L
fig|749531.3.peg.1241
Escherichia coli MS 69-1 (12-516/517)
M
W
D
D
--
LAD
VY
G
HK
TA
L
I
CE
S
S
GG
VV
N
--
-
-R
YSY
L
ELNQ
EI
N
R
T
AN
LFYTL
GI
R
K
GD
KV
A
L
H
L
D
N
CP
EF
IFC
W
F
G
L
A
KIGA
IM
VP
I
N
A
R
LL
R
E
E
S
T
W
I
L
QNS
QA
CLLVTS
A
QFYP
MYQ
QI
Q
-
--
--
---
Q
ED
A
T
QL
RH
I
CLT
D
VALP
A
D
DG
V
S
S
FT
QL
K
N
-
----------
Q
Q
PAT
LC
Y
A
P
P
LST
D
D
T
A
EI
LFTSGTT
S
R
PKGV
VI
TH
Y
N
LRF
A
G
Y
Y
S
AWQ
C
A
L
R
D
D
DVYL
TVM
PA
F
H
IDCQCT
A
AM
A
A
-----
F
S
AG
T
T
F
VL
VEKY
SA
R
A
F
WG
Q
V
Q
K
Y
R
A
T
I
T
ECI
P
M
M
IR
T
L
M
V
Q
P
P
SAN
D
RQ
H
R
L
RE
V
M
F
Y
L
-
--
-N
LS
EQEK
DA
F
C
E
R
F
G
V
H
LL
T
S
YGMTE
TIV
-
G
I
IG
---
-
D
R
P
GD
K
RRWP
S
I
GR
A
G
F
CY
-
---
E
AE
I
R
DD
HNR
PLP
A
GE
L
GE
ICI
KGVP
G
K
TI
F
K
E
YF
LN
P
K
A
TA
K
V
L
E
A
D
GW
L
H
T
GD
T
GYR
DEEG
FF
YFV
D
R
R
CN
M
I
K
RGGEN
V
S
CV
E
L
ENI
IA
A
HPKI
Q
D
I
V
VV
G
I
K
D
S
IR
D
E
A
IK
A
F
VVL
N
E
G
-
ET
LS
E
EE
F
F
RF
-C
EQ
N
M
AKFK
V
P
SY
L
E
IR
K
D
LPR
N
C
SGKI
I
R
K
N
L
fig|216593.1.peg.3541
Escherichia coli E2348/69 (17-521/522)
M
W
D
D
--
LAD
VY
G
HK
TA
L
I
CE
S
S
S
G
VV
N
--
-
-R
YSY
L
ELNQ
EI
N
R
T
AN
LFYTL
GI
R
K
GD
KV
A
L
H
L
D
N
CP
EF
IFC
W
F
G
L
A
KIGA
IM
VP
I
N
A
R
LL
R
E
E
S
T
W
I
L
QNS
QA
CLLVTS
A
QFYP
MYQ
QI
Q
-
--
--
---
Q
ED
A
T
QL
RH
I
CLT
D
VSLP
A
D
DG
V
S
S
FT
QL
K
N
-
----------
Q
Q
PAT
LC
Y
A
P
P
LST
D
D
T
A
EI
LFTSGTT
S
R
PKGV
VI
TH
Y
N
LRF
A
G
Y
Y
S
AWQ
C
A
L
R
D
D
DVYL
TVM
PA
F
H
IDCQCT
A
AM
A
A
-----
F
S
T
GAT
F
VL
VEKY
SA
R
A
F
WG
Q
V
Q
K
Y
R
A
T
I
T
ECI
P
M
M
IR
T
L
M
V
Q
P
L
SAN
D
QQ
H
R
L
RE
V
M
F
Y
L
-
--
-N
LS
EQEK
DA
F
C
E
R
F
G
V
RLL
T
S
YGMTE
TIV
-
G
I
IG
---
-
D
R
P
GD
K
RRWP
S
I
G
Q
A
G
F
CY
-
---
E
AE
I
R
DD
HNR
PLP
A
GE
I
GE
ICI
KGVP
G
K
TI
F
K
E
YF
LN
P
K
A
TA
K
V
L
E
A
D
GW
L
H
T
GD
T
GYR
DEEG
FF
YFV
D
R
R
CN
M
I
K
RGGEN
V
S
CV
E
L
ENI
IA
T
HPKI
Q
D
I
V
VV
G
I
K
D
S
IR
D
E
A
IK
A
F
VVL
N
E
G
-
ET
LS
E
EE
F
F
C
F
-C
EQ
N
M
AKFK
V
L
SY
L
E
IR
K
D
LPR
N
C
SGKI
I
R
K
N
L
fig|574521.7.peg.39
Escherichia coli O127:H6 str. E2348/69 (17-521/522)
M
W
D
D
--
LAD
VY
G
HK
TA
L
I
CE
S
S
S
G
VV
N
--
-
-R
YSY
L
ELNQ
EI
N
R
T
AN
LFYTL
GI
R
K
GD
KV
A
L
H
L
D
N
CP
EF
IFC
W
F
G
L
A
KIGA
IM
VP
I
N
A
R
LL
R
E
E
S
T
W
I
L
QNS
QA
CLLVTS
A
QFYP
MYQ
QI
Q
-
--
--
---
Q
ED
A
T
QL
RH
I
CLT
D
VSLP
A
D
DG
V
S
S
FT
QL
K
N
-
----------
Q
Q
PAT
LC
Y
A
P
P
LST
D
D
T
A
EI
LFTSGTT
S
R
PKGV
VI
TH
Y
N
LRF
A
G
Y
Y
S
AWQ
C
A
L
R
D
D
DVYL
TVM
PA
F
H
IDCQCT
A
AM
A
A
-----
F
S
T
GAT
F
VL
VEKY
SA
R
A
F
WG
Q
V
Q
K
Y
R
A
T
I
T
ECI
P
M
M
IR
T
L
M
V
Q
P
L
SAN
D
QQ
H
R
L
RE
V
M
F
Y
L
-
--
-N
LS
EQEK
DA
F
C
E
R
F
G
V
RLL
T
S
YGMTE
TIV
-
G
I
IG
---
-
D
R
P
GD
K
RRWP
S
I
G
Q
A
G
F
CY
-
---
E
AE
I
R
DD
HNR
PLP
A
GE
I
GE
ICI
KGVP
G
K
TI
F
K
E
YF
LN
P
K
A
TA
K
V
L
E
A
D
GW
L
H
T
GD
T
GYR
DEEG
FF
YFV
D
R
R
CN
M
I
K
RGGEN
V
S
CV
E
L
ENI
IA
T
HPKI
Q
D
I
V
VV
G
I
K
D
S
IR
D
E
A
IK
A
F
VVL
N
E
G
-
ET
LS
E
EE
F
F
C
F
-C
EQ
N
M
AKFK
V
L
SY
L
E
IR
K
D
LPR
N
C
SGKI
I
R
K
N
L
fig|405955.9.peg.31
Escherichia coli APEC O1 (17-521/522)
M
W
D
D
--
LAD
VY
G
HK
TA
L
I
CE
S
S
GG
VV
N
--
-
-R
YSY
L
ELNQ
EI
N
R
T
AN
LFYTL
GI
R
K
GD
KV
A
L
H
L
D
N
CP
EF
IFC
W
F
G
L
A
KIGA
IM
VP
I
N
A
R
LL
R
E
E
S
T
W
I
L
QNS
QA
CLLVTS
A
QFYP
MYQ
QI
Q
-
--
--
---
Q
ED
A
S
QL
RH
I
CLI
D
MALP
A
D
DG
V
S
S
FT
QL
K
N
-
----------
Q
Q
PAT
LC
Y
A
P
P
LST
D
D
T
A
EI
LFTSGTT
S
R
PKGV
VI
TH
Y
N
LRF
A
G
Y
Y
S
AWQ
C
A
L
R
D
D
DVYL
TVM
PA
F
H
IDCQCT
A
AM
A
A
-----
F
S
AGAT
F
VL
VEKY
SA
R
A
F
WG
Q
V
Q
K
Y
R
A
T
I
T
ECI
P
M
M
IR
T
L
M
V
Q
P
P
SAN
D
RQ
H
R
L
RE
V
M
F
Y
L
-
--
-N
LS
EQEK
DA
F
C
E
R
F
G
V
RLL
T
S
YGMTE
TIV
-
G
I
IG
---
-
D
R
P
GD
K
RRWP
S
I
GR
A
G
F
CY
-
---
E
AE
I
R
DD
HNR
PLP
A
GE
L
GE
ICI
KGVP
G
K
TI
F
K
E
YF
LN
P
K
A
TA
K
V
L
E
A
D
GW
L
H
T
GD
T
GYR
DEEG
FF
YFV
D
R
R
CN
M
I
K
RGGEN
V
S
CV
E
L
ENI
IA
T
HPKI
Q
D
I
V
VV
G
I
K
D
S
IR
D
E
A
IK
A
F
VVL
N
E
G
-
ET
LS
E
EE
F
F
C
F
-C
EQ
N
M
AKFK
V
P
SY
L
E
IR
K
D
LPR
N
C
SGKI
I
R
K
N
L
fig|405955.13.peg.40
Escherichia coli APEC O1 (12-516/517)
M
W
D
D
--
LAD
VY
G
HK
TA
L
I
CE
S
S
GG
VV
N
--
-
-R
YSY
L
ELNQ
EI
N
R
T
AN
LFYTL
GI
R
K
GD
KV
A
L
H
L
D
N
CP
EF
IFC
W
F
G
L
A
KIGA
IM
VP
I
N
A
R
LL
R
E
E
S
T
W
I
L
QNS
QA
CLLVTS
A
QFYP
MYQ
QI
Q
-
--
--
---
Q
ED
A
S
QL
RH
I
CLI
D
MALP
A
D
DG
V
S
S
FT
QL
K
N
-
----------
Q
Q
PAT
LC
Y
A
P
P
LST
D
D
T
A
EI
LFTSGTT
S
R
PKGV
VI
TH
Y
N
LRF
A
G
Y
Y
S
AWQ
C
A
L
R
D
D
DVYL
TVM
PA
F
H
IDCQCT
A
AM
A
A
-----
F
S
AGAT
F
VL
VEKY
SA
R
A
F
WG
Q
V
Q
K
Y
R
A
T
I
T
ECI
P
M
M
IR
T
L
M
V
Q
P
P
SAN
D
RQ
H
R
L
RE
V
M
F
Y
L
-
--
-N
LS
EQEK
DA
F
C
E
R
F
G
V
RLL
T
S
YGMTE
TIV
-
G
I
IG
---
-
D
R
P
GD
K
RRWP
S
I
GR
A
G
F
CY
-
---
E
AE
I
R
DD
HNR
PLP
A
GE
L
GE
ICI
KGVP
G
K
TI
F
K
E
YF
LN
P
K
A
TA
K
V
L
E
A
D
GW
L
H
T
GD
T
GYR
DEEG
FF
YFV
D
R
R
CN
M
I
K
RGGEN
V
S
CV
E
L
ENI
IA
T
HPKI
Q
D
I
V
VV
G
I
K
D
S
IR
D
E
A
IK
A
F
VVL
N
E
G
-
ET
LS
E
EE
F
F
C
F
-C
EQ
N
M
AKFK
V
P
SY
L
E
IR
K
D
LPR
N
C
SGKI
I
R
K
N
L
fig|714962.3.peg.38
Escherichia coli IHE3034 (12-516/517)
M
W
D
D
--
LAD
VY
G
HK
TA
L
I
CE
S
S
GG
VV
N
--
-
-R
YSY
L
ELNQ
EI
N
R
T
AN
LFYTL
GI
R
K
GD
KV
A
L
H
L
D
N
CP
EF
IFC
W
F
G
L
A
KIGA
IM
VP
I
N
A
R
LL
R
E
E
S
T
W
I
L
QNS
QA
CLLVTS
A
QFYP
MYQ
QI
Q
-
--
--
---
Q
ED
A
S
QL
RH
I
CLI
D
MALP
A
D
DG
V
S
S
FT
QL
K
N
-
----------
Q
Q
PAT
LC
Y
A
P
P
LST
D
D
T
A
EI
LFTSGTT
S
R
PKGV
VI
TH
Y
N
LRF
A
G
Y
Y
S
AWQ
C
A
L
R
D
D
DVYL
TVM
PA
F
H
IDCQCT
A
AM
A
A
-----
F
S
AGAT
F
VL
VEKY
SA
R
A
F
WG
Q
V
Q
K
Y
R
A
T
I
T
ECI
P
M
M
IR
T
L
M
V
Q
P
P
SAN
D
RQ
H
R
L
RE
V
M
F
Y
L
-
--
-N
LS
EQEK
DA
F
C
E
R
F
G
V
RLL
T
S
YGMTE
TIV
-
G
I
IG
---
-
D
R
P
GD
K
RRWP
S
I
GR
A
G
F
CY
-
---
E
AE
I
R
DD
HNR
PLP
A
GE
L
GE
ICI
KGVP
G
K
TI
F
K
E
YF
LN
P
K
A
TA
K
V
L
E
A
D
GW
L
H
T
GD
T
GYR
DEEG
FF
YFV
D
R
R
CN
M
I
K
RGGEN
V
S
CV
E
L
ENI
IA
T
HPKI
Q
D
I
V
VV
G
I
K
D
S
IR
D
E
A
IK
A
F
VVL
N
E
G
-
ET
LS
E
EE
F
F
C
F
-C
EQ
N
M
AKFK
V
P
SY
L
E
IR
K
D
LPR
N
C
SGKI
I
R
K
N
L
fig|753642.3.peg.3601
Escherichia coli NC101 (12-516/517)
M
W
D
D
--
LAD
VY
G
HK
TA
L
I
CE
S
S
GG
VV
N
--
-
-R
YSY
L
ELNQ
EI
N
R
T
AN
LFYTL
GI
R
K
GD
KV
A
L
H
L
D
N
CP
EF
IFC
W
F
G
L
A
KIGA
IM
VP
I
N
A
R
LL
R
E
E
S
T
W
I
L
QNS
QA
CLLVTS
A
QFYP
MYQ
QI
Q
-
--
--
---
Q
ED
A
S
QL
RH
I
CLI
D
MALP
A
D
DG
V
S
S
FT
QL
K
N
-
----------
Q
Q
PAT
LC
Y
A
P
P
LST
D
D
T
A
EI
LFTSGTT
S
R
PKGV
VI
TH
Y
N
LRF
A
G
Y
Y
S
AWQ
C
A
L
R
D
D
DVYL
TVM
PA
F
H
IDCQCT
A
AM
A
A
-----
F
S
AGAT
F
VL
VEKY
SA
R
A
F
WG
Q
V
Q
K
Y
R
A
T
I
T
ECI
P
M
M
IR
T
L
M
V
Q
P
P
SAN
D
RQ
H
R
L
RE
V
M
F
Y
L
-
--
-N
LS
EQEK
DA
F
C
E
R
F
G
V
RLL
T
S
YGMTE
TIV
-
G
I
IG
---
-
D
R
P
GD
K
RRWP
S
I
GR
A
G
F
CY
-
---
E
AE
I
R
DD
HNR
PLP
A
GE
L
GE
ICI
KGVP
G
K
TI
F
K
E
YF
LN
P
K
A
TA
K
V
L
E
A
D
GW
L
H
T
GD
T
GYR
DEEG
FF
YFV
D
R
R
CN
M
I
K
RGGEN
V
S
CV
E
L
ENI
IA
T
HPKI
Q
D
I
V
VV
G
I
K
D
S
IR
D
E
A
IK
A
F
VVL
N
E
G
-
ET
LS
E
EE
F
F
C
F
-C
EQ
N
M
AKFK
V
P
SY
L
E
IR
K
D
LPR
N
C
SGKI
I
R
K
N
L
fig|869729.3.peg.4938
Escherichia coli UM146 (12-516/517)
M
W
D
D
--
LAD
VY
G
HK
TA
L
I
CE
S
S
GG
VV
N
--
-
-R
YSY
L
ELNQ
EI
N
R
T
AN
LFYTL
GI
R
K
GD
KV
A
L
H
L
D
N
CP
EF
IFC
W
F
G
L
A
KIGA
IM
VP
I
N
A
R
LL
R
E
E
S
T
W
I
L
QNS
QA
CLLVTS
A
QFYP
MYQ
QI
Q
-
--
--
---
Q
ED
A
S
QL
RH
I
CLI
D
MALP
A
D
DG
V
S
S
FT
QL
K
N
-
----------
Q
Q
PAT
LC
Y
A
P
P
LST
D
D
T
A
EI
LFTSGTT
S
R
PKGV
VI
TH
Y
N
LRF
A
G
Y
Y
S
AWQ
C
A
L
R
D
D
DVYL
TVM
PA
F
H
IDCQCT
A
AM
A
A
-----
F
S
AGAT
F
VL
VEKY
SA
R
A
F
WG
Q
V
Q
K
Y
R
A
T
I
T
ECI
P
M
M
IR
T
L
M
V
Q
P
P
SAN
D
RQ
H
R
L
RE
V
M
F
Y
L
-
--
-N
LS
EQEK
DA
F
C
E
R
F
G
V
RLL
T
S
YGMTE
TIV
-
G
I
IG
---
-
D
R
P
GD
K
RRWP
S
I
GR
A
G
F
CY
-
---
E
AE
I
R
DD
HNR
PLP
A
GE
L
GE
ICI
KGVP
G
K
TI
F
K
E
YF
LN
P
K
A
TA
K
V
L
E
A
D
GW
L
H
T
GD
T
GYR
DEEG
FF
YFV
D
R
R
CN
M
I
K
RGGEN
V
S
CV
E
L
ENI
IA
T
HPKI
Q
D
I
V
VV
G
I
K
D
S
IR
D
E
A
IK
A
F
VVL
N
E
G
-
ET
LS
E
EE
F
F
C
F
-C
EQ
N
M
AKFK
V
P
SY
L
E
IR
K
D
LPR
N
C
SGKI
I
R
K
N
L
fig|364106.7.peg.172
Escherichia coli UTI89 (12-516/517)
M
W
D
D
--
LAD
VY
G
HK
TA
L
I
CE
S
S
GG
VV
N
--
-
-R
YSY
L
ELNQ
EI
N
R
T
AN
LFYTL
GI
R
K
GD
KV
A
L
H
L
D
N
CP
EF
IFC
W
F
G
L
A
KIGA
IM
VP
I
N
A
R
LL
R
E
E
S
T
W
I
L
QNS
QA
CLLVTS
A
QFYP
MYQ
QI
Q
-
--
--
---
Q
ED
A
S
QL
RH
I
CLI
D
MALP
A
D
DG
V
S
S
FT
QL
K
N
-
----------
Q
Q
PAT
LC
Y
A
P
P
LST
D
D
T
A
EI
LFTSGTT
S
R
PKGV
VI
TH
Y
N
LRF
A
G
Y
Y
S
AWQ
C
A
L
R
D
D
DVYL
TVM
PA
F
H
IDCQCT
A
AM
A
A
-----
F
S
AGAT
F
VL
VEKY
SA
R
A
F
WG
Q
V
Q
K
Y
R
A
T
I
T
ECI
P
M
M
IR
T
L
M
V
Q
P
P
SAN
D
RQ
H
R
L
RE
V
M
F
Y
L
-
--
-N
LS
EQEK
DA
F
C
E
R
F
G
V
RLL
T
S
YGMTE
TIV
-
G
I
IG
---
-
D
R
P
GD
K
RRWP
S
I
GR
A
G
F
CY
-
---
E
AE
I
R
DD
HNR
PLP
A
GE
L
GE
ICI
KGVP
G
K
TI
F
K
E
YF
LN
P
K
A
TA
K
V
L
E
A
D
GW
L
H
T
GD
T
GYR
DEEG
FF
YFV
D
R
R
CN
M
I
K
RGGEN
V
S
CV
E
L
ENI
IA
T
HPKI
Q
D
I
V
VV
G
I
K
D
S
IR
D
E
A
IK
A
F
VVL
N
E
G
-
ET
LS
E
EE
F
F
C
F
-C
EQ
N
M
AKFK
V
P
SY
L
E
IR
K
D
LPR
N
C
SGKI
I
R
K
N
L
fig|364106.8.peg.171
Escherichia coli UTI89 (12-516/517)
M
W
D
D
--
LAD
VY
G
HK
TA
L
I
CE
S
S
GG
VV
N
--
-
-R
YSY
L
ELNQ
EI
N
R
T
AN
LFYTL
GI
R
K
GD
KV
A
L
H
L
D
N
CP
EF
IFC
W
F
G
L
A
KIGA
IM
VP
I
N
A
R
LL
R
E
E
S
T
W
I
L
QNS
QA
CLLVTS
A
QFYP
MYQ
QI
Q
-
--
--
---
Q
ED
A
S
QL
RH
I
CLI
D
MALP
A
D
DG
V
S
S
FT
QL
K
N
-
----------
Q
Q
PAT
LC
Y
A
P
P
LST
D
D
T
A
EI
LFTSGTT
S
R
PKGV
VI
TH
Y
N
LRF
A
G
Y
Y
S
AWQ
C
A
L
R
D
D
DVYL
TVM
PA
F
H
IDCQCT
A
AM
A
A
-----
F
S
AGAT
F
VL
VEKY
SA
R
A
F
WG
Q
V
Q
K
Y
R
A
T
I
T
ECI
P
M
M
IR
T
L
M
V
Q
P
P
SAN
D
RQ
H
R
L
RE
V
M
F
Y
L
-
--
-N
LS
EQEK
DA
F
C
E
R
F
G
V
RLL
T
S
YGMTE
TIV
-
G
I
IG
---
-
D
R
P
GD
K
RRWP
S
I
GR
A
G
F
CY
-
---
E
AE
I
R
DD
HNR
PLP
A
GE
L
GE
ICI
KGVP
G
K
TI
F
K
E
YF
LN
P
K
A
TA
K
V
L
E
A
D
GW
L
H
T
GD
T
GYR
DEEG
FF
YFV
D
R
R
CN
M
I
K
RGGEN
V
S
CV
E
L
ENI
IA
T
HPKI
Q
D
I
V
VV
G
I
K
D
S
IR
D
E
A
IK
A
F
VVL
N
E
G
-
ET
LS
E
EE
F
F
C
F
-C
EQ
N
M
AKFK
V
P
SY
L
E
IR
K
D
LPR
N
C
SGKI
I
R
K
N
L
fig|585397.7.peg.39
Escherichia coli ED1a (12-516/517)
M
W
D
D
--
LAD
VY
G
HK
TA
L
I
CE
S
S
S
G
VV
N
--
-
-R
YSY
L
ELNQ
EI
N
R
T
AN
LFYVL
GI
R
K
GD
KV
A
L
H
L
D
N
CP
EF
IFC
W
F
G
L
A
KIGA
IM
VP
I
N
A
R
LL
R
E
E
S
T
W
I
L
QNS
QA
CLLVTS
A
QFYP
MYQ
QI
Q
-
--
--
---
Q
ED
A
S
E
L
RH
I
CLT
D
MALP
A
D
DG
V
S
S
FT
QL
K
N
-
----------
Q
Q
PAT
LC
Y
A
P
P
LST
D
D
T
A
EI
LFTSGTT
S
R
PKGV
VI
TH
Y
N
LRF
A
G
Y
Y
S
AWQ
C
A
L
R
D
D
DVYL
TVM
PA
F
H
IDCQCT
A
AM
A
A
-----
F
S
AGAT
F
VL
VEKY
SA
R
A
F
WG
Q
V
Q
K
Y
R
A
T
I
T
ECI
P
M
M
IR
T
L
M
V
Q
P
P
SAN
D
QQ
H
R
L
RE
V
M
F
Y
L
-
--
-N
LS
EQEK
DA
F
C
E
R
F
G
V
RLL
T
S
YGMTE
TIV
-
G
I
IG
---
-
D
R
P
GD
K
RRWP
S
I
GR
A
G
F
CY
-
---
E
AE
I
C
DD
HNR
PLP
A
GE
I
GE
ICI
KGVP
G
K
TI
F
K
E
YF
LN
P
K
A
TA
K
V
L
E
A
D
GW
L
H
T
GD
T
GYR
DEEG
FF
YFV
D
R
R
CN
M
I
K
RGGEN
V
S
CV
E
L
ENI
IA
T
HPKI
Q
D
I
V
VV
G
I
K
D
S
IR
D
E
A
IK
A
F
VVL
N
E
G
-
ET
LS
E
EE
F
F
C
F
-C
EQ
N
M
AKFK
V
P
SY
L
E
IR
K
D
LPR
N
C
SGKI
I
R
K
N
L
fig|585397.9.peg.39
Escherichia coli ED1a (12-516/517)
M
W
D
D
--
LAD
VY
G
HK
TA
L
I
CE
S
S
S
G
VV
N
--
-
-R
YSY
L
ELNQ
EI
N
R
T
AN
LFYVL
GI
R
K
GD
KV
A
L
H
L
D
N
CP
EF
IFC
W
F
G
L
A
KIGA
IM
VP
I
N
A
R
LL
R
E
E
S
T
W
I
L
QNS
QA
CLLVTS
A
QFYP
MYQ
QI
Q
-
--
--
---
Q
ED
A
S
E
L
RH
I
CLT
D
MALP
A
D
DG
V
S
S
FT
QL
K
N
-
----------
Q
Q
PAT
LC
Y
A
P
P
LST
D
D
T
A
EI
LFTSGTT
S
R
PKGV
VI
TH
Y
N
LRF
A
G
Y
Y
S
AWQ
C
A
L
R
D
D
DVYL
TVM
PA
F
H
IDCQCT
A
AM
A
A
-----
F
S
AGAT
F
VL
VEKY
SA
R
A
F
WG
Q
V
Q
K
Y
R
A
T
I
T
ECI
P
M
M
IR
T
L
M
V
Q
P
P
SAN
D
QQ
H
R
L
RE
V
M
F
Y
L
-
--
-N
LS
EQEK
DA
F
C
E
R
F
G
V
RLL
T
S
YGMTE
TIV
-
G
I
IG
---
-
D
R
P
GD
K
RRWP
S
I
GR
A
G
F
CY
-
---
E
AE
I
C
DD
HNR
PLP
A
GE
I
GE
ICI
KGVP
G
K
TI
F
K
E
YF
LN
P
K
A
TA
K
V
L
E
A
D
GW
L
H
T
GD
T
GYR
DEEG
FF
YFV
D
R
R
CN
M
I
K
RGGEN
V
S
CV
E
L
ENI
IA
T
HPKI
Q
D
I
V
VV
G
I
K
D
S
IR
D
E
A
IK
A
F
VVL
N
E
G
-
ET
LS
E
EE
F
F
C
F
-C
EQ
N
M
AKFK
V
P
SY
L
E
IR
K
D
LPR
N
C
SGKI
I
R
K
N
L
fig|585035.6.peg.40
Escherichia coli S88 (12-516/517)
M
W
D
D
--
LAD
VY
G
HK
TA
L
I
CE
S
S
GG
VV
N
--
-
-R
YSY
L
ELNQ
EI
N
R
T
AN
LFYTL
GI
R
K
GD
KV
A
L
H
L
D
N
CP
EF
IFC
W
F
G
L
A
KIGA
IM
VP
I
N
A
R
LL
R
E
E
S
T
W
I
L
QNS
QA
CLLVTS
A
QFYP
MYQ
QI
Q
-
--
--
---
Q
ED
A
S
QL
RH
I
CLI
D
MALP
A
D
DG
V
S
S
FT
QL
K
N
-
----------
Q
Q
PAT
LC
Y
A
P
P
LST
D
D
T
A
EI
LFTSGTT
S
R
PKGV
VI
TH
Y
N
LRF
A
G
Y
Y
S
AWQ
C
A
L
R
D
D
DVYL
TVM
PA
F
H
IDCQCT
A
AM
A
A
-----
F
S
AGAT
F
VL
VEKY
SA
R
A
F
WG
Q
V
Q
K
Y
R
A
T
I
T
ECI
P
M
M
IR
T
L
M
V
Q
P
P
SAN
D
RQ
H
R
L
RE
V
M
F
Y
L
-
--
-N
LS
EQEK
DA
F
C
E
R
F
G
V
S
LL
T
S
YGMTE
TIV
-
G
I
IG
---
-
D
R
P
GD
K
RRWP
S
I
GR
A
G
F
CY
-
---
E
AE
I
R
DD
HNR
PLP
A
GE
L
GE
ICI
KGVP
G
K
TI
F
K
E
YF
LN
P
K
A
TA
K
V
L
E
A
D
GW
L
H
T
GD
T
GYR
DEEG
FF
YFV
D
R
R
CN
M
I
K
RGGEN
V
S
CV
E
L
ENI
IA
T
HPKI
Q
D
I
V
VV
G
I
K
D
S
IR
D
E
A
IK
A
F
VVL
N
E
G
-
ET
LS
E
EE
F
F
C
F
-C
EQ
N
M
AKFK
V
P
SY
L
E
IR
K
D
LPR
N
C
SGKI
I
R
K
N
L
fig|431946.3.peg.39
Escherichia coli SE15 (12-516/517)
M
W
D
D
--
LAD
VY
G
HK
TA
L
I
CE
S
S
S
G
VV
N
--
-
-R
YSY
L
ELNQ
EI
N
R
T
AN
LFYTL
GI
R
K
GD
KV
A
L
H
L
D
N
CP
EF
IFC
W
F
G
L
A
KIGA
IM
VP
I
N
A
R
LL
R
E
E
S
T
W
I
L
QNS
QA
CLLVTS
A
QFYP
MYQ
QI
Q
-
--
--
---
Q
ED
A
S
QL
RH
I
CLT
D
MALP
A
D
DG
V
S
S
FT
QL
K
N
-
----------
Q
Q
PAT
LC
Y
A
P
P
LST
D
D
T
A
EI
LFTSGTT
S
R
PKGV
VI
TH
Y
N
LRF
A
G
Y
Y
S
AWQ
C
A
L
R
D
D
DVYL
TVM
PA
F
H
IDCQCT
A
AM
A
A
-----
F
S
AGAT
F
VL
VEKY
SA
R
A
F
WG
Q
V
Q
K
Y
R
A
T
I
T
ECI
P
M
M
IR
T
L
M
V
Q
P
P
SAN
D
RQ
H
R
L
RE
V
M
F
Y
L
-
--
-N
LS
EQEK
DA
F
C
E
R
F
G
V
RLL
T
S
YGMTE
TIV
-
G
I
IG
---
-
D
R
P
GD
K
RRWP
S
I
GR
A
G
F
CY
-
---
E
AE
I
R
DD
HNR
PLP
A
GE
I
GE
ICI
KGVP
G
K
TI
F
K
E
YF
LN
P
K
A
TA
K
V
L
E
A
D
GW
L
H
T
GD
T
GYR
DEEG
FF
YFV
D
R
R
CN
M
I
K
RGGEN
V
S
CV
E
L
ENI
IA
T
HPKI
Q
D
I
V
VV
G
I
K
D
S
IR
D
E
A
IK
A
F
VVL
N
E
G
-
ET
LS
E
EE
F
F
RF
-C
EQ
N
M
AKFK
V
P
SY
L
E
IR
K
D
LPR
N
C
SGKI
I
R
K
N
L
fig|749527.3.peg.4031
Escherichia coli MS 21-1 (12-516/517)
M
W
D
D
--
LAD
VY
G
HK
TA
L
I
CE
S
S
GG
VV
N
--
-
-R
YSY
L
ELNQ
EI
N
R
T
AN
LFYTL
GI
R
K
GD
KV
A
L
H
L
D
N
CP
EF
IFC
W
F
G
L
A
KIGA
IM
VP
I
N
A
R
LL
R
E
E
S
A
W
I
L
QNS
QA
CLLVTS
A
QFYP
MYQ
QI
Q
-
--
--
---
Q
ED
A
T
QL
RH
I
CLT
D
VALP
A
D
DG
V
S
S
FT
QL
K
N
-
----------
Q
Q
PAT
LC
Y
A
P
P
LST
D
D
T
A
EI
LFTSGTT
S
R
PKGV
VI
TH
Y
N
LRF
A
G
Y
Y
S
AWQ
C
A
L
R
D
D
DVYL
TVM
PA
F
H
IDCQCT
A
AM
A
A
-----
F
S
AGAT
F
VL
VEKY
SA
R
A
F
WG
Q
V
Q
K
Y
R
A
T
I
T
ECI
P
M
M
IR
T
L
M
V
Q
S
P
SAN
D
QQ
H
R
L
RE
V
M
F
Y
L
-
--
-N
LS
EQEK
DA
F
C
E
R
F
G
V
RLL
T
S
YGMTE
TIV
-
G
I
IG
---
-
D
R
P
GD
K
RRWP
S
I
GR
A
G
F
CY
-
---
E
AE
I
R
DD
HNR
PLP
A
GE
I
GE
ICI
KGVP
G
K
TI
F
K
E
YF
LN
P
K
A
TA
K
V
L
E
A
D
GW
L
H
T
GD
T
GYR
DEEG
FF
YFV
D
R
R
CN
M
I
K
RGGEN
V
S
CV
E
L
ENI
IA
A
HPKI
Q
D
I
V
VV
G
I
K
D
S
IR
D
E
A
IK
A
F
VVL
N
E
G
-
ET
LS
E
EE
F
F
RF
-C
E
K
N
M
AKFK
V
P
SY
L
E
IR
K
D
LPR
N
C
SGKI
I
R
K
N
L
fig|656417.3.peg.98
Escherichia coli M605 (12-516/517)
M
W
D
D
--
LAD
VY
G
HK
TA
L
I
CE
S
S
S
G
VV
N
--
-
-R
YSY
L
ELNQ
EI
N
R
T
AN
LFYTL
GI
R
K
GD
KV
A
L
H
L
D
N
CP
EF
IFC
W
F
G
L
A
KIGA
IM
VP
I
N
A
R
LL
R
E
E
S
T
W
I
L
QNS
QA
CLLVTS
A
QFYP
MYQ
QI
Q
-
--
--
---
Q
ED
A
S
QL
RH
I
CLT
D
MALP
A
D
DG
V
S
S
FT
QL
K
N
-
----------
Q
Q
PAT
LC
Y
A
P
P
LST
D
D
T
A
EI
LFTSGTT
S
R
PKGV
VI
TH
Y
N
LRF
A
G
Y
Y
S
AWQ
C
A
L
R
D
D
DVYL
TVM
PA
F
H
IDCQCT
A
AM
A
A
-----
F
S
AGAT
F
VL
VEKY
SA
R
A
F
WG
Q
V
Q
K
Y
R
A
T
I
T
ECI
P
M
M
IR
T
L
M
V
Q
P
P
SAN
D
RQ
H
R
L
RE
V
M
F
Y
L
-
--
-N
LS
EQEK
DA
F
C
E
R
F
G
V
RLL
T
S
YGMTE
TIV
-
G
I
IG
---
-
D
R
P
GD
K
RRWP
S
I
GR
A
G
F
CY
-
---
E
AE
I
R
DD
HNR
PLP
A
GE
I
GE
ICI
KGVP
G
K
TI
F
K
E
YF
LN
P
K
A
TA
K
M
L
E
A
D
GW
L
H
T
GD
T
GYR
DEEG
FF
YFV
D
R
R
CN
M
I
K
RGGEN
V
S
CV
E
L
ENI
IA
T
HPKI
Q
D
I
V
VV
G
I
K
D
S
IR
D
E
A
IK
A
F
VVL
N
E
G
-
ET
LS
E
EE
F
F
RF
-C
EQ
N
M
AKFK
V
P
SY
L
E
IR
K
D
LPR
N
C
SGKI
I
R
K
N
L
fig|439855.10.peg.212
Escherichia coli SMS-3-5 (12-516/517)
M
W
D
D
--
LAD
VY
G
HK
TA
L
I
CE
S
S
GG
VV
N
--
-
-R
YSY
L
ELNQ
EI
N
R
T
AN
LFYTL
GI
R
K
GD
KV
A
L
H
L
D
N
CP
EF
IFC
W
F
G
L
A
KIGA
IM
VP
I
N
A
R
LL
R
E
E
S
A
W
I
L
QNS
QA
CLLVTS
A
QFYP
MYQ
QI
Q
-
--
--
---
Q
ED
A
T
QL
RH
I
CLT
D
VALP
A
D
DG
V
S
S
FT
QL
K
N
-
----------
Q
Q
PAT
LC
Y
A
P
P
LST
D
D
T
A
EI
LFTSGTT
S
R
PKGV
VI
TH
Y
N
LRF
A
G
Y
Y
S
AWQ
C
A
L
R
D
D
DVYL
TVM
PA
F
H
IDCQCT
A
AM
A
A
-----
F
S
AGAT
F
VL
VEKY
SA
R
A
F
WG
Q
V
Q
K
Y
R
A
T
I
T
ECI
P
M
M
IR
T
L
M
V
Q
P
P
SAN
D
QQ
H
R
L
RE
V
M
F
Y
L
-
--
-N
LS
AQEK
DA
F
C
E
R
F
G
V
RLL
T
S
YGMTE
TIV
-
G
I
IG
---
-
D
R
P
GD
K
RRWP
S
I
GR
A
G
F
CY
-
---
E
AE
I
R
DD
HNR
PLP
A
GE
I
GE
ICI
KGVP
G
K
TI
F
K
E
YF
LN
P
K
A
TA
K
V
L
E
A
D
GW
L
H
T
GD
T
GYR
DEEG
FF
YFV
D
R
R
CN
M
I
K
RGGEN
V
S
CV
E
L
ENI
IA
T
HPKI
Q
D
I
V
VV
G
I
K
D
S
IR
D
E
A
IK
A
F
VVL
N
E
G
-
ET
LS
E
EE
F
F
RF
-C
EQ
N
M
AKFK
V
P
SY
L
E
IR
K
D
LPR
N
C
SGKI
I
R
K
N
L
fig|585057.4.peg.40
Escherichia coli IAI39 (12-516/517)
M
W
D
D
--
LAD
VY
G
HK
TA
L
I
CE
S
S
GG
VV
N
--
-
-R
YSY
L
ELNQ
EI
N
R
T
AN
LFYTL
GI
R
K
GD
KV
A
L
H
L
D
N
CP
EF
IFC
W
F
G
L
A
KIGA
IM
VP
I
N
A
R
LL
R
E
E
S
A
W
I
L
QNS
QA
CLLVTS
A
QFYP
MYQ
QI
Q
-
--
--
---
Q
ED
A
T
QL
RH
I
CLT
D
VALP
A
D
DG
V
S
S
FT
QL
K
N
-
----------
Q
Q
PAT
LC
Y
A
P
P
LST
D
D
T
A
EI
LFTSGTT
S
R
PKGV
VI
TH
Y
N
LRF
A
G
Y
Y
S
AWQ
C
A
L
R
D
D
DVYL
TVM
PA
F
H
IDCQCT
A
AM
A
A
-----
F
S
AGAT
F
VL
VEKY
SA
R
A
F
WG
Q
V
Q
K
Y
R
A
T
I
T
ECI
P
M
M
IR
T
L
M
V
Q
P
P
SAN
D
QQ
H
R
L
RE
V
M
F
Y
L
-
--
-N
LS
AQEK
DA
F
C
E
R
F
G
V
RLL
T
S
YGMTE
TIV
-
G
I
IG
---
-
D
R
P
GD
K
RRWP
S
I
GR
A
G
F
CY
-
---
E
AE
I
R
DD
HNR
PLP
A
GE
I
GE
ICI
KGVP
G
K
TI
F
K
E
YF
LN
P
K
A
TA
K
V
L
E
A
D
GW
L
H
T
GD
T
GYR
DEEG
FF
YFA
D
R
R
CN
M
I
K
RGGEN
V
S
CV
E
L
ENI
IA
A
HPKI
Q
D
I
V
VV
G
I
K
D
S
IR
D
E
A
IK
A
F
VVL
N
E
G
-
ET
LS
E
EE
F
F
RF
-C
EQ
N
M
AKFK
V
P
SY
L
E
IR
K
D
LPR
N
C
SGKI
I
R
K
N
L
fig|585057.6.peg.40
Escherichia coli IAI39 (12-516/517)
M
W
D
D
--
LAD
VY
G
HK
TA
L
I
CE
S
S
GG
VV
N
--
-
-R
YSY
L
ELNQ
EI
N
R
T
AN
LFYTL
GI
R
K
GD
KV
A
L
H
L
D
N
CP
EF
IFC
W
F
G
L
A
KIGA
IM
VP
I
N
A
R
LL
R
E
E
S
A
W
I
L
QNS
QA
CLLVTS
A
QFYP
MYQ
QI
Q
-
--
--
---
Q
ED
A
T
QL
RH
I
CLT
D
VALP
A
D
DG
V
S
S
FT
QL
K
N
-
----------
Q
Q
PAT
LC
Y
A
P
P
LST
D
D
T
A
EI
LFTSGTT
S
R
PKGV
VI
TH
Y
N
LRF
A
G
Y
Y
S
AWQ
C
A
L
R
D
D
DVYL
TVM
PA
F
H
IDCQCT
A
AM
A
A
-----
F
S
AGAT
F
VL
VEKY
SA
R
A
F
WG
Q
V
Q
K
Y
R
A
T
I
T
ECI
P
M
M
IR
T
L
M
V
Q
P
P
SAN
D
QQ
H
R
L
RE
V
M
F
Y
L
-
--
-N
LS
AQEK
DA
F
C
E
R
F
G
V
RLL
T
S
YGMTE
TIV
-
G
I
IG
---
-
D
R
P
GD
K
RRWP
S
I
GR
A
G
F
CY
-
---
E
AE
I
R
DD
HNR
PLP
A
GE
I
GE
ICI
KGVP
G
K
TI
F
K
E
YF
LN
P
K
A
TA
K
V
L
E
A
D
GW
L
H
T
GD
T
GYR
DEEG
FF
YFA
D
R
R
CN
M
I
K
RGGEN
V
S
CV
E
L
ENI
IA
A
HPKI
Q
D
I
V
VV
G
I
K
D
S
IR
D
E
A
IK
A
F
VVL
N
E
G
-
ET
LS
E
EE
F
F
RF
-C
EQ
N
M
AKFK
V
P
SY
L
E
IR
K
D
LPR
N
C
SGKI
I
R
K
N
L
fig|340185.3.peg.4592
Escherichia coli E22 (17-521/522)
M
W
D
D
--
LAD
VY
G
HK
TA
L
I
CE
S
S
GG
VV
N
--
-
-R
YSY
L
ELNQ
EI
N
R
T
AN
LFYTL
GI
R
K
GD
KV
A
L
H
L
D
N
CP
EF
IFC
W
F
G
L
A
KIGA
IM
VP
I
N
A
R
LL
R
E
E
S
A
W
I
L
QNS
QA
CLLVTS
A
QFYP
MYQ
QI
Q
-
--
--
---
Q
ED
A
T
QL
RH
I
CLT
D
VALP
A
D
DG
M
S
S
FT
QL
K
N
-
----------
Q
Q
PAT
LC
Y
A
P
P
LST
D
D
T
A
EI
LFTSGTT
S
R
PKGV
VI
TH
Y
N
LRF
A
G
Y
Y
S
AWQ
C
A
L
R
D
D
DVYL
TVM
PA
F
H
IDCQCT
A
AM
A
A
-----
F
S
AGAT
F
VL
VEKY
SA
R
A
F
WG
Q
V
Q
K
Y
R
A
T
I
T
ECI
P
M
M
IR
T
L
M
V
Q
P
P
SAN
D
RQ
H
R
L
RE
V
M
F
Y
L
-
--
-N
LS
EQEK
DA
F
C
E
R
F
G
V
RLL
T
S
YGMTE
TIV
-
G
I
IG
---
-
D
R
P
GD
K
RRWP
S
I
GR
A
G
F
CY
-
---
E
AE
I
R
DD
HNR
PLP
A
GE
I
GE
ICI
KGVP
G
K
TI
F
K
E
YF
LN
P
K
A
TA
K
V
L
E
A
D
GW
L
H
T
GD
T
GYC
DEEG
FF
YFV
D
R
R
CN
M
I
K
RGGEN
V
S
CV
E
L
ENI
IA
T
HPKI
Q
D
I
V
VV
G
I
K
D
S
IR
D
E
A
IK
A
F
VVL
N
E
G
-
ET
LS
E
EE
F
F
RF
-C
EQ
N
M
AKFK
V
P
SY
L
E
IR
K
D
LPR
N
C
SGKI
I
R
K
N
L
fig|340185.4.peg.4840
Escherichia coli E22 (12-516/517)
M
W
D
D
--
LAD
VY
G
HK
TA
L
I
CE
S
S
GG
VV
N
--
-
-R
YSY
L
ELNQ
EI
N
R
T
AN
LFYTL
GI
R
K
GD
KV
A
L
H
L
D
N
CP
EF
IFC
W
F
G
L
A
KIGA
IM
VP
I
N
A
R
LL
R
E
E
S
A
W
I
L
QNS
QA
CLLVTS
A
QFYP
MYQ
QI
Q
-
--
--
---
Q
ED
A
T
QL
RH
I
CLT
D
VALP
A
D
DG
M
S
S
FT
QL
K
N
-
----------
Q
Q
PAT
LC
Y
A
P
P
LST
D
D
T
A
EI
LFTSGTT
S
R
PKGV
VI
TH
Y
N
LRF
A
G
Y
Y
S
AWQ
C
A
L
R
D
D
DVYL
TVM
PA
F
H
IDCQCT
A
AM
A
A
-----
F
S
AGAT
F
VL
VEKY
SA
R
A
F
WG
Q
V
Q
K
Y
R
A
T
I
T
ECI
P
M
M
IR
T
L
M
V
Q
P
P
SAN
D
RQ
H
R
L
RE
V
M
F
Y
L
-
--
-N
LS
EQEK
DA
F
C
E
R
F
G
V
RLL
T
S
YGMTE
TIV
-
G
I
IG
---
-
D
R
P
GD
K
RRWP
S
I
GR
A
G
F
CY
-
---
E
AE
I
R
DD
HNR
PLP
A
GE
I
GE
ICI
KGVP
G
K
TI
F
K
E
YF
LN
P
K
A
TA
K
V
L
E
A
D
GW
L
H
T
GD
T
GYC
DEEG
FF
YFV
D
R
R
CN
M
I
K
RGGEN
V
S
CV
E
L
ENI
IA
T
HPKI
Q
D
I
V
VV
G
I
K
D
S
IR
D
E
A
IK
A
F
VVL
N
E
G
-
ET
LS
E
EE
F
F
RF
-C
EQ
N
M
AKFK
V
P
SY
L
E
IR
K
D
LPR
N
C
SGKI
I
R
K
N
L
fig|1040638.4.peg.5595
Escherichia coli O104:H4 str. LB226692 (12-516/517)
M
W
D
D
--
LAD
VY
G
HK
TA
L
I
CE
S
S
GG
VV
N
--
-
-R
YSY
L
ELNQ
EI
N
R
T
AN
LFYTL
GI
R
K
GD
KV
A
L
H
L
D
N
CP
EF
IFC
W
F
G
L
A
KIGA
IM
VP
I
N
A
R
LL
R
E
E
S
A
W
I
L
QNS
QA
CLLVTS
A
QFYP
MYQ
QI
Q
-
--
--
---
Q
ED
A
T
QL
RH
I
CLT
D
VALP
A
D
DG
V
S
S
FT
QL
K
N
-
----------
Q
Q
PAT
LC
Y
A
P
P
LST
D
D
T
A
EI
LFTSGTT
S
R
PKGV
VI
TH
Y
N
LRF
A
G
Y
Y
S
AWQ
C
A
L
R
D
D
DVYL
TVM
PA
F
H
IDCQCT
A
AM
A
A
-----
F
S
AGAT
F
VL
VEKY
SA
R
A
F
WG
Q
V
Q
K
Y
R
A
T
I
T
ECI
P
M
M
IR
T
L
M
V
Q
P
P
SAN
D
RQ
H
R
L
RE
V
M
F
Y
L
-
--
-N
LS
EQEK
DA
F
C
E
R
F
G
V
RLL
T
S
YGMTE
TIV
-
G
I
IG
---
-
D
R
P
SD
K
RRWP
S
I
GR
A
G
F
CY
-
---
E
AE
I
R
DD
HNR
PLP
A
GE
I
GE
ICI
KGVP
G
K
TI
F
K
E
YF
LN
P
K
A
TA
K
V
L
E
A
D
GW
L
H
T
GD
T
GYC
DEEG
FF
YFV
D
R
R
CN
M
I
K
RGGEN
V
S
CV
E
L
ENI
IA
T
HPKI
Q
D
I
V
VV
G
I
K
D
S
IR
D
E
A
IK
A
F
VVL
N
E
G
-
ET
LS
E
EE
F
F
RF
-C
EQ
N
M
AKFK
V
P
SY
L
E
IR
K
D
LPR
N
C
SGKI
I
R
K
N
L
fig|585055.6.peg.38
Escherichia coli 55989 (12-516/517)
M
W
D
D
--
LAD
VY
G
HK
TA
L
I
CE
S
S
GG
VV
N
--
-
-R
YSY
L
ELNQ
EI
N
R
T
AN
LFYTL
GI
R
K
GD
KV
A
L
H
L
D
N
CP
EF
IFC
W
F
G
L
A
KIGA
IM
VP
I
N
A
R
LL
R
E
E
S
A
W
I
L
QNS
QA
CLLVTS
A
QFYP
MYQ
QI
Q
-
--
--
---
Q
ED
A
T
QL
RH
I
CLT
D
VALP
A
D
DG
V
S
S
FT
QL
K
N
-
----------
Q
Q
PAT
LC
Y
A
P
P
LST
D
D
T
A
EI
LFTSGTT
S
R
PKGV
VI
TH
Y
N
LRF
A
G
Y
Y
S
AWQ
C
A
L
R
D
D
DVYL
TVM
PA
F
H
IDCQCT
A
AM
A
A
-----
F
S
AGAT
F
VL
VEKY
SA
R
A
F
WG
Q
V
Q
K
Y
R
A
T
I
T
ECI
P
M
M
IR
T
L
M
V
Q
P
P
SAN
D
RQ
H
R
L
RE
V
M
F
Y
L
-
--
-N
LS
EQEK
DA
F
C
E
R
F
G
V
RLL
T
S
YGMTE
TIV
-
G
I
IG
---
-
D
R
P
SD
K
RRWP
S
I
GR
A
G
F
CY
-
---
E
AE
I
R
DD
HNR
PLP
A
GE
I
GE
ICI
KGVP
G
K
TI
F
K
E
YF
LN
P
K
A
TA
K
V
L
E
A
D
GW
L
H
T
GD
T
GYC
DEEG
FF
YFV
D
R
R
CN
M
I
K
RGGEN
V
S
CV
E
L
ENI
IA
T
HPKI
Q
D
I
V
VV
G
I
K
D
S
IR
D
E
A
IK
A
F
VVL
N
E
G
-
ET
LS
E
EE
F
F
RF
-C
EQ
N
M
AKFK
V
P
SY
L
E
IR
K
D
LPR
N
C
SGKI
I
R
K
N
L
fig|585055.8.peg.38
Escherichia coli 55989 (12-516/517)
M
W
D
D
--
LAD
VY
G
HK
TA
L
I
CE
S
S
GG
VV
N
--
-
-R
YSY
L
ELNQ
EI
N
R
T
AN
LFYTL
GI
R
K
GD
KV
A
L
H
L
D
N
CP
EF
IFC
W
F
G
L
A
KIGA
IM
VP
I
N
A
R
LL
R
E
E
S
A
W
I
L
QNS
QA
CLLVTS
A
QFYP
MYQ
QI
Q
-
--
--
---
Q
ED
A
T
QL
RH
I
CLT
D
VALP
A
D
DG
V
S
S
FT
QL
K
N
-
----------
Q
Q
PAT
LC
Y
A
P
P
LST
D
D
T
A
EI
LFTSGTT
S
R
PKGV
VI
TH
Y
N
LRF
A
G
Y
Y
S
AWQ
C
A
L
R
D
D
DVYL
TVM
PA
F
H
IDCQCT
A
AM
A
A
-----
F
S
AGAT
F
VL
VEKY
SA
R
A
F
WG
Q
V
Q
K
Y
R
A
T
I
T
ECI
P
M
M
IR
T
L
M
V
Q
P
P
SAN
D
RQ
H
R
L
RE
V
M
F
Y
L
-
--
-N
LS
EQEK
DA
F
C
E
R
F
G
V
RLL
T
S
YGMTE
TIV
-
G
I
IG
---
-
D
R
P
SD
K
RRWP
S
I
GR
A
G
F
CY
-
---
E
AE
I
R
DD
HNR
PLP
A
GE
I
GE
ICI
KGVP
G
K
TI
F
K
E
YF
LN
P
K
A
TA
K
V
L
E
A
D
GW
L
H
T
GD
T
GYC
DEEG
FF
YFV
D
R
R
CN
M
I
K
RGGEN
V
S
CV
E
L
ENI
IA
T
HPKI
Q
D
I
V
VV
G
I
K
D
S
IR
D
E
A
IK
A
F
VVL
N
E
G
-
ET
LS
E
EE
F
F
RF
-C
EQ
N
M
AKFK
V
P
SY
L
E
IR
K
D
LPR
N
C
SGKI
I
R
K
N
L
fig|216592.1.peg.4379
Escherichia coli 042 (17-521/522)
M
W
D
D
--
LAD
VY
G
HK
TA
L
I
CE
S
S
GG
VV
N
--
-
-R
YSY
L
ELNQ
EI
N
R
T
AN
LFYTL
GI
R
K
GD
KV
A
L
H
L
D
N
CP
EF
IFC
W
F
G
L
A
KIGA
IM
VP
I
N
A
R
LL
R
E
E
S
A
W
I
L
QNS
QA
CLLVTS
A
QFYP
MYQ
QI
Q
-
--
--
---
Q
ED
A
T
QL
RH
I
CLT
D
VALP
A
D
DG
V
S
S
FT
QL
K
N
-
----------
Q
Q
PAT
LC
Y
A
P
P
LST
D
D
T
A
EI
LFTSGTT
S
R
PKGV
VI
TH
Y
N
LRF
A
G
Y
Y
S
AWQ
C
A
L
R
D
D
DVYL
TVM
PA
F
H
IDCQCT
A
AM
A
A
-----
F
S
AGAT
F
VL
VEKY
SA
R
A
F
WG
Q
V
Q
K
Y
R
A
T
V
T
ECI
P
M
M
IR
T
L
M
V
Q
P
P
SAN
D
RQ
H
R
L
RE
V
M
F
Y
L
-
--
-N
LS
EQEK
DA
F
C
E
R
F
G
V
RLL
T
S
YGMTE
TIV
-
G
S
IG
---
-
D
R
P
GD
K
RRWP
S
I
GR
A
G
F
CY
-
---
E
AE
I
R
DD
HNR
PLP
A
GE
I
GE
ICI
KGVP
G
K
TI
F
K
E
YF
LN
P
K
A
TA
K
V
L
E
V
D
GW
L
H
T
GD
T
GYC
DEEG
FF
YFV
D
R
R
CN
M
I
K
RGGEN
V
S
CV
E
L
ENI
IA
T
HPKI
Q
D
I
V
VV
G
I
K
D
S
IR
D
E
A
IK
A
F
VVL
N
E
G
-
ET
LS
E
EE
F
F
RF
-C
EQ
N
M
AKFK
V
P
SY
L
E
IR
K
D
LPR
N
C
SGKI
I
R
K
N
L
fig|216592.3.peg.43
Escherichia coli 042 (12-516/517)
M
W
D
D
--
LAD
VY
G
HK
TA
L
I
CE
S
S
GG
VV
N
--
-
-R
YSY
L
ELNQ
EI
N
R
T
AN
LFYTL
GI
R
K
GD
KV
A
L
H
L
D
N
CP
EF
IFC
W
F
G
L
A
KIGA
IM
VP
I
N
A
R
LL
R
E
E
S
A
W
I
L
QNS
QA
CLLVTS
A
QFYP
MYQ
QI
Q
-
--
--
---
Q
ED
A
T
QL
RH
I
CLT
D
VALP
A
D
DG
V
S
S
FT
QL
K
N
-
----------
Q
Q
PAT
LC
Y
A
P
P
LST
D
D
T
A
EI
LFTSGTT
S
R
PKGV
VI
TH
Y
N
LRF
A
G
Y
Y
S
AWQ
C
A
L
R
D
D
DVYL
TVM
PA
F
H
IDCQCT
A
AM
A
A
-----
F
S
AGAT
F
VL
VEKY
SA
R
A
F
WG
Q
V
Q
K
Y
R
A
T
V
T
ECI
P
M
M
IR
T
L
M
V
Q
P
P
SAN
D
RQ
H
R
L
RE
V
M
F
Y
L
-
--
-N
LS
EQEK
DA
F
C
E
R
F
G
V
RLL
T
S
YGMTE
TIV
-
G
S
IG
---
-
D
R
P
GD
K
RRWP
S
I
GR
A
G
F
CY
-
---
E
AE
I
R
DD
HNR
PLP
A
GE
I
GE
ICI
KGVP
G
K
TI
F
K
E
YF
LN
P
K
A
TA
K
V
L
E
V
D
GW
L
H
T
GD
T
GYC
DEEG
FF
YFV
D
R
R
CN
M
I
K
RGGEN
V
S
CV
E
L
ENI
IA
T
HPKI
Q
D
I
V
VV
G
I
K
D
S
IR
D
E
A
IK
A
F
VVL
N
E
G
-
ET
LS
E
EE
F
F
RF
-C
EQ
N
M
AKFK
V
P
SY
L
E
IR
K
D
LPR
N
C
SGKI
I
R
K
N
L
fig|585395.4.peg.36
Escherichia coli O103:H2 str. 12009 (12-516/517)
M
W
D
D
--
LAD
VY
G
HK
TA
L
I
YE
S
S
GG
VV
N
--
-
-R
YSY
L
ELNQ
EI
N
R
T
AN
LFYTL
GI
R
K
GD
KV
A
L
H
L
D
N
CP
EF
IFC
W
F
G
L
A
KIGA
IM
VP
I
N
A
R
LL
R
E
E
S
A
W
I
L
QNS
QA
CLLVTS
A
QFYP
MYQ
QI
Q
-
--
--
---
Q
ED
A
T
QL
RH
I
CLT
D
VALP
A
D
DG
V
S
S
FT
QL
K
N
-
----------
Q
Q
PAT
LC
Y
A
P
P
LST
D
D
T
A
EI
LFTSGTT
S
R
PKGV
VI
TH
Y
N
LRF
A
G
Y
Y
S
AWQ
C
A
L
R
D
D
DVYL
TVM
PA
F
H
IDCQCT
A
AM
A
A
-----
F
S
AGAT
F
VL
VEKY
SA
R
A
F
WG
Q
V
Q
K
Y
R
A
T
I
T
ECI
P
M
M
IR
T
L
M
V
Q
P
P
SAN
D
RQ
H
R
L
RE
V
M
F
Y
L
-
--
-N
LS
EQEK
DA
F
C
E
R
F
G
V
RLL
T
S
YGMTE
TIV
-
G
I
IG
---
-
D
R
P
GD
K
RRWP
S
I
GR
A
G
F
CY
-
---
E
AE
I
R
DD
HNR
PLP
A
GE
I
GE
ICI
KGVP
G
K
TI
F
K
E
YF
LN
P
K
A
TA
K
V
L
E
A
D
GW
L
H
T
GD
T
GYC
DEEG
FF
YFV
D
R
R
CN
M
I
K
RGGEN
V
S
CV
E
L
ENI
IA
T
HPKI
Q
D
I
V
VV
G
I
K
D
S
IR
D
E
A
IK
A
F
VVL
N
E
G
-
ET
LS
E
EE
F
F
RF
-C
EQ
N
M
AKFK
V
P
SY
L
E
IR
K
D
LPR
N
C
SGKI
I
R
K
N
L
fig|199310.1.peg.44
Escherichia coli CFT073 (17-521/522)
M
W
D
D
--
LAD
VY
G
HK
TA
L
I
CE
S
S
S
G
VV
N
--
-
-R
YSY
L
ELNQ
EI
N
R
T
AN
LFYTL
GI
R
K
GD
KV
A
L
H
L
D
N
CP
EF
IFC
W
F
G
L
A
KIGA
IM
VP
I
N
A
R
LL
R
E
E
S
T
W
I
L
QNS
QA
CLLVTS
A
QFYP
MYQ
QI
Q
-
--
--
---
Q
ED
A
S
QL
RH
I
CLT
D
MVLP
A
D
DG
V
S
S
FT
QL
K
N
-
----------
Q
Q
PAT
LC
Y
A
P
P
LST
D
D
T
A
EI
LFTSGTT
S
R
PKGV
VI
TH
Y
N
LRF
A
G
Y
Y
S
AWQ
C
A
L
R
D
D
DVYL
TVM
PA
F
H
IDCQCT
A
AM
A
A
-----
F
S
AGAT
F
VL
VEKY
SA
R
A
F
WG
Q
V
Q
K
Y
R
A
T
I
T
ECI
P
M
M
IR
T
L
M
V
Q
P
L
SAN
D
QQ
H
R
L
RE
V
M
F
Y
L
-
--
-N
LS
EQEK
DA
F
C
E
R
F
S
V
RLL
T
S
YGMTE
TIV
-
G
I
IG
---
-
D
R
P
GD
K
RRWP
S
I
GR
A
G
F
CY
-
---
E
AE
I
R
DD
HNR
PLP
A
GE
L
GE
ICI
KGVP
G
K
TI
F
K
E
YF
LN
P
K
A
TA
K
V
L
E
A
D
GW
L
H
T
GD
T
GYR
DEEG
FF
YFV
D
R
R
CN
M
I
K
RGGEN
V
S
CV
E
L
ENI
IA
T
HPKI
Q
D
I
V
VV
G
I
K
D
S
IR
D
E
A
IK
A
F
VVL
N
E
G
-
ET
LS
E
EE
F
F
C
F
-C
EQ
N
M
AKFK
V
P
SY
L
E
IR
K
D
LPR
N
C
SGKI
I
R
K
N
L
fig|340197.3.peg.4249
Escherichia coli F11 (17-521/522)
M
W
D
D
--
LAD
VY
G
HK
TA
L
I
CE
S
S
S
G
VV
N
--
-
-R
YSY
L
ELNQ
EI
N
R
T
AN
LFYTL
GI
R
K
GD
KV
A
L
H
L
D
N
CP
EF
IFC
W
F
G
L
A
KIGA
IM
VP
I
N
A
R
LL
R
E
E
S
T
W
I
L
QNS
QA
CLLVTS
A
QFYP
MYQ
QI
Q
-
--
--
---
Q
ED
A
S
QL
RH
I
CLT
D
MVLP
A
D
DG
V
S
S
FT
QL
K
N
-
----------
Q
Q
PAT
LC
Y
A
P
P
LST
D
D
T
A
EI
LFTSGTT
S
R
PKGV
VI
TH
Y
N
LRF
A
G
Y
Y
S
AWQ
C
A
L
R
D
D
DVYL
TVM
PA
F
H
IDCQCT
A
AM
A
A
-----
F
S
AGAT
F
VL
VEKY
SA
R
A
F
WG
Q
V
Q
K
Y
R
A
T
I
T
ECI
P
M
M
IR
T
L
M
V
Q
P
L
SAN
D
QQ
H
R
L
RE
V
M
F
Y
L
-
--
-N
LS
EQEK
DA
F
C
E
R
F
S
V
RLL
T
S
YGMTE
TIV
-
G
I
IG
---
-
D
R
P
GD
K
RRWP
S
I
GR
A
G
F
CY
-
---
E
AE
I
R
DD
HNR
PLP
A
GE
L
GE
ICI
KGVP
G
K
TI
F
K
E
YF
LN
P
K
A
TA
K
V
L
E
A
D
GW
L
H
T
GD
T
GYR
DEEG
FF
YFV
D
R
R
CN
M
I
K
RGGEN
V
S
CV
E
L
ENI
IA
T
HPKI
Q
D
I
V
VV
G
I
K
D
S
IR
D
E
A
IK
A
F
VVL
N
E
G
-
ET
LS
E
EE
F
F
C
F
-C
EQ
N
M
AKFK
V
P
SY
L
E
IR
K
D
LPR
N
C
SGKI
I
R
K
N
L
fig|362663.8.peg.39
Escherichia coli 536 (12-516/517)
M
W
D
D
--
LAD
VY
G
HK
TA
L
I
CE
S
S
S
G
VV
N
--
-
-R
YSY
L
ELNQ
EI
N
R
T
AN
LFYTL
GI
R
K
GD
KV
A
L
H
L
D
N
CP
EF
IFC
W
F
G
L
A
KIGA
IM
VP
I
N
A
R
LL
R
E
E
S
T
W
I
L
QNS
QA
CLLVTS
A
QFYP
MYQ
QI
Q
-
--
--
---
Q
ED
A
S
QL
RH
I
CLT
D
MVLP
A
D
DG
V
S
S
FT
QL
K
N
-
----------
Q
Q
PAT
LC
Y
A
P
P
LST
D
D
T
A
EI
LFTSGTT
S
R
PKGV
VI
TH
Y
N
LRF
A
G
Y
Y
S
AWQ
C
A
L
R
D
D
DVYL
TVM
PA
F
H
IDCQCT
A
AM
A
A
-----
F
S
AGAT
F
VL
VEKY
SA
R
A
F
WG
Q
V
Q
K
Y
R
A
T
I
T
ECI
P
M
M
IR
T
L
M
V
Q
P
L
SAN
D
QQ
H
R
L
RE
V
M
F
Y
L
-
--
-N
LS
EQEK
DA
F
C
E
R
F
S
V
RLL
T
S
YGMTE
TIV
-
G
I
IG
---
-
D
R
P
GD
K
RRWP
S
I
GR
A
G
F
CY
-
---
E
AE
I
R
DD
HNR
PLP
A
GE
L
GE
ICI
KGVP
G
K
TI
F
K
E
YF
LN
P
K
A
TA
K
V
L
E
A
D
GW
L
H
T
GD
T
GYR
DEEG
FF
YFV
D
R
R
CN
M
I
K
RGGEN
V
S
CV
E
L
ENI
IA
T
HPKI
Q
D
I
V
VV
G
I
K
D
S
IR
D
E
A
IK
A
F
VVL
N
E
G
-
ET
LS
E
EE
F
F
C
F
-C
EQ
N
M
AKFK
V
P
SY
L
E
IR
K
D
LPR
N
C
SGKI
I
R
K
N
L
fig|362663.9.peg.39
Escherichia coli 536 (12-516/517)
M
W
D
D
--
LAD
VY
G
HK
TA
L
I
CE
S
S
S
G
VV
N
--
-
-R
YSY
L
ELNQ
EI
N
R
T
AN
LFYTL
GI
R
K
GD
KV
A
L
H
L
D
N
CP
EF
IFC
W
F
G
L
A
KIGA
IM
VP
I
N
A
R
LL
R
E
E
S
T
W
I
L
QNS
QA
CLLVTS
A
QFYP
MYQ
QI
Q
-
--
--
---
Q
ED
A
S
QL
RH
I
CLT
D
MVLP
A
D
DG
V
S
S
FT
QL
K
N
-
----------
Q
Q
PAT
LC
Y
A
P
P
LST
D
D
T
A
EI
LFTSGTT
S
R
PKGV
VI
TH
Y
N
LRF
A
G
Y
Y
S
AWQ
C
A
L
R
D
D
DVYL
TVM
PA
F
H
IDCQCT
A
AM
A
A
-----
F
S
AGAT
F
VL
VEKY
SA
R
A
F
WG
Q
V
Q
K
Y
R
A
T
I
T
ECI
P
M
M
IR
T
L
M
V
Q
P
L
SAN
D
QQ
H
R
L
RE
V
M
F
Y
L
-
--
-N
LS
EQEK
DA
F
C
E
R
F
S
V
RLL
T
S
YGMTE
TIV
-
G
I
IG
---
-
D
R
P
GD
K
RRWP
S
I
GR
A
G
F
CY
-
---
E
AE
I
R
DD
HNR
PLP
A
GE
L
GE
ICI
KGVP
G
K
TI
F
K
E
YF
LN
P
K
A
TA
K
V
L
E
A
D
GW
L
H
T
GD
T
GYR
DEEG
FF
YFV
D
R
R
CN
M
I
K
RGGEN
V
S
CV
E
L
ENI
IA
T
HPKI
Q
D
I
V
VV
G
I
K
D
S
IR
D
E
A
IK
A
F
VVL
N
E
G
-
ET
LS
E
EE
F
F
C
F
-C
EQ
N
M
AKFK
V
P
SY
L
E
IR
K
D
LPR
N
C
SGKI
I
R
K
N
L
fig|525281.3.peg.1234
Escherichia coli 83972 (12-516/517)
M
W
D
D
--
LAD
VY
G
HK
TA
L
I
CE
S
S
S
G
VV
N
--
-
-R
YSY
L
ELNQ
EI
N
R
T
AN
LFYTL
GI
R
K
GD
KV
A
L
H
L
D
N
CP
EF
IFC
W
F
G
L
A
KIGA
IM
VP
I
N
A
R
LL
R
E
E
S
T
W
I
L
QNS
QA
CLLVTS
A
QFYP
MYQ
QI
Q
-
--
--
---
Q
ED
A
S
QL
RH
I
CLT
D
MVLP
A
D
DG
V
S
S
FT
QL
K
N
-
----------
Q
Q
PAT
LC
Y
A
P
P
LST
D
D
T
A
EI
LFTSGTT
S
R
PKGV
VI
TH
Y
N
LRF
A
G
Y
Y
S
AWQ
C
A
L
R
D
D
DVYL
TVM
PA
F
H
IDCQCT
A
AM
A
A
-----
F
S
AGAT
F
VL
VEKY
SA
R
A
F
WG
Q
V
Q
K
Y
R
A
T
I
T
ECI
P
M
M
IR
T
L
M
V
Q
P
L
SAN
D
QQ
H
R
L
RE
V
M
F
Y
L
-
--
-N
LS
EQEK
DA
F
C
E
R
F
S
V
RLL
T
S
YGMTE
TIV
-
G
I
IG
---
-
D
R
P
GD
K
RRWP
S
I
GR
A
G
F
CY
-
---
E
AE
I
R
DD
HNR
PLP
A
GE
L
GE
ICI
KGVP
G
K
TI
F
K
E
YF
LN
P
K
A
TA
K
V
L
E
A
D
GW
L
H
T
GD
T
GYR
DEEG
FF
YFV
D
R
R
CN
M
I
K
RGGEN
V
S
CV
E
L
ENI
IA
T
HPKI
Q
D
I
V
VV
G
I
K
D
S
IR
D
E
A
IK
A
F
VVL
N
E
G
-
ET
LS
E
EE
F
F
C
F
-C
EQ
N
M
AKFK
V
P
SY
L
E
IR
K
D
LPR
N
C
SGKI
I
R
K
N
L
fig|655817.3.peg.42
Escherichia coli ABU 83972 (12-516/517)
M
W
D
D
--
LAD
VY
G
HK
TA
L
I
CE
S
S
S
G
VV
N
--
-
-R
YSY
L
ELNQ
EI
N
R
T
AN
LFYTL
GI
R
K
GD
KV
A
L
H
L
D
N
CP
EF
IFC
W
F
G
L
A
KIGA
IM
VP
I
N
A
R
LL
R
E
E
S
T
W
I
L
QNS
QA
CLLVTS
A
QFYP
MYQ
QI
Q
-
--
--
---
Q
ED
A
S
QL
RH
I
CLT
D
MVLP
A
D
DG
V
S
S
FT
QL
K
N
-
----------
Q
Q
PAT
LC
Y
A
P
P
LST
D
D
T
A
EI
LFTSGTT
S
R
PKGV
VI
TH
Y
N
LRF
A
G
Y
Y
S
AWQ
C
A
L
R
D
D
DVYL
TVM
PA
F
H
IDCQCT
A
AM
A
A
-----
F
S
AGAT
F
VL
VEKY
SA
R
A
F
WG
Q
V
Q
K
Y
R
A
T
I
T
ECI
P
M
M
IR
T
L
M
V
Q
P
L
SAN
D
QQ
H
R
L
RE
V
M
F
Y
L
-
--
-N
LS
EQEK
DA
F
C
E
R
F
S
V
RLL
T
S
YGMTE
TIV
-
G
I
IG
---
-
D
R
P
GD
K
RRWP
S
I
GR
A
G
F
CY
-
---
E
AE
I
R
DD
HNR
PLP
A
GE
L
GE
ICI
KGVP
G
K
TI
F
K
E
YF
LN
P
K
A
TA
K
V
L
E
A
D
GW
L
H
T
GD
T
GYR
DEEG
FF
YFV
D
R
R
CN
M
I
K
RGGEN
V
S
CV
E
L
ENI
IA
T
HPKI
Q
D
I
V
VV
G
I
K
D
S
IR
D
E
A
IK
A
F
VVL
N
E
G
-
ET
LS
E
EE
F
F
C
F
-C
EQ
N
M
AKFK
V
P
SY
L
E
IR
K
D
LPR
N
C
SGKI
I
R
K
N
L
fig|199310.4.peg.42
Escherichia coli CFT073 (12-516/517)
M
W
D
D
--
LAD
VY
G
HK
TA
L
I
CE
S
S
S
G
VV
N
--
-
-R
YSY
L
ELNQ
EI
N
R
T
AN
LFYTL
GI
R
K
GD
KV
A
L
H
L
D
N
CP
EF
IFC
W
F
G
L
A
KIGA
IM
VP
I
N
A
R
LL
R
E
E
S
T
W
I
L
QNS
QA
CLLVTS
A
QFYP
MYQ
QI
Q
-
--
--
---
Q
ED
A
S
QL
RH
I
CLT
D
MVLP
A
D
DG
V
S
S
FT
QL
K
N
-
----------
Q
Q
PAT
LC
Y
A
P
P
LST
D
D
T
A
EI
LFTSGTT
S
R
PKGV
VI
TH
Y
N
LRF
A
G
Y
Y
S
AWQ
C
A
L
R
D
D
DVYL
TVM
PA
F
H
IDCQCT
A
AM
A
A
-----
F
S
AGAT
F
VL
VEKY
SA
R
A
F
WG
Q
V
Q
K
Y
R
A
T
I
T
ECI
P
M
M
IR
T
L
M
V
Q
P
L
SAN
D
QQ
H
R
L
RE
V
M
F
Y
L
-
--
-N
LS
EQEK
DA
F
C
E
R
F
S
V
RLL
T
S
YGMTE
TIV
-
G
I
IG
---
-
D
R
P
GD
K
RRWP
S
I
GR
A
G
F
CY
-
---
E
AE
I
R
DD
HNR
PLP
A
GE
L
GE
ICI
KGVP
G
K
TI
F
K
E
YF
LN
P
K
A
TA
K
V
L
E
A
D
GW
L
H
T
GD
T
GYR
DEEG
FF
YFV
D
R
R
CN
M
I
K
RGGEN
V
S
CV
E
L
ENI
IA
T
HPKI
Q
D
I
V
VV
G
I
K
D
S
IR
D
E
A
IK
A
F
VVL
N
E
G
-
ET
LS
E
EE
F
F
C
F
-C
EQ
N
M
AKFK
V
P
SY
L
E
IR
K
D
LPR
N
C
SGKI
I
R
K
N
L
fig|340197.5.peg.4433
Escherichia coli F11 (12-516/517)
M
W
D
D
--
LAD
VY
G
HK
TA
L
I
CE
S
S
S
G
VV
N
--
-
-R
YSY
L
ELNQ
EI
N
R
T
AN
LFYTL
GI
R
K
GD
KV
A
L
H
L
D
N
CP
EF
IFC
W
F
G
L
A
KIGA
IM
VP
I
N
A
R
LL
R
E
E
S
T
W
I
L
QNS
QA
CLLVTS
A
QFYP
MYQ
QI
Q
-
--
--
---
Q
ED
A
S
QL
RH
I
CLT
D
MVLP
A
D
DG
V
S
S
FT
QL
K
N
-
----------
Q
Q
PAT
LC
Y
A
P
P
LST
D
D
T
A
EI
LFTSGTT
S
R
PKGV
VI
TH
Y
N
LRF
A
G
Y
Y
S
AWQ
C
A
L
R
D
D
DVYL
TVM
PA
F
H
IDCQCT
A
AM
A
A
-----
F
S
AGAT
F
VL
VEKY
SA
R
A
F
WG
Q
V
Q
K
Y
R
A
T
I
T
ECI
P
M
M
IR
T
L
M
V
Q
P
L
SAN
D
QQ
H
R
L
RE
V
M
F
Y
L
-
--
-N
LS
EQEK
DA
F
C
E
R
F
S
V
RLL
T
S
YGMTE
TIV
-
G
I
IG
---
-
D
R
P
GD
K
RRWP
S
I
GR
A
G
F
CY
-
---
E
AE
I
R
DD
HNR
PLP
A
GE
L
GE
ICI
KGVP
G
K
TI
F
K
E
YF
LN
P
K
A
TA
K
V
L
E
A
D
GW
L
H
T
GD
T
GYR
DEEG
FF
YFV
D
R
R
CN
M
I
K
RGGEN
V
S
CV
E
L
ENI
IA
T
HPKI
Q
D
I
V
VV
G
I
K
D
S
IR
D
E
A
IK
A
F
VVL
N
E
G
-
ET
LS
E
EE
F
F
C
F
-C
EQ
N
M
AKFK
V
P
SY
L
E
IR
K
D
LPR
N
C
SGKI
I
R
K
N
L
fig|749546.3.peg.2339
Escherichia coli MS 185-1 (12-516/517)
M
W
D
D
--
LAD
VY
G
HK
TA
L
I
CE
S
S
S
G
VV
N
--
-
-R
YSY
L
ELNQ
EI
N
R
T
AN
LFYTL
GI
R
K
GD
KV
A
L
H
L
D
N
CP
EF
IFC
W
F
G
L
A
KIGA
IM
VP
I
N
A
R
LL
R
E
E
S
T
W
I
L
QNS
QA
CLLVTS
A
QFYP
MYQ
QI
Q
-
--
--
---
Q
ED
A
S
QL
RH
I
CLT
D
MVLP
A
D
DG
V
S
S
FT
QL
K
N
-
----------
Q
Q
PAT
LC
Y
A
P
P
LST
D
D
T
A
EI
LFTSGTT
S
R
PKGV
VI
TH
Y
N
LRF
A
G
Y
Y
S
AWQ
C
A
L
R
D
D
DVYL
TVM
PA
F
H
IDCQCT
A
AM
A
A
-----
F
S
AGAT
F
VL
VEKY
SA
R
A
F
WG
Q
V
Q
K
Y
R
A
T
I
T
ECI
P
M
M
IR
T
L
M
V
Q
P
L
SAN
D
QQ
H
R
L
RE
V
M
F
Y
L
-
--
-N
LS
EQEK
DA
F
C
E
R
F
S
V
RLL
T
S
YGMTE
TIV
-
G
I
IG
---
-
D
R
P
GD
K
RRWP
S
I
GR
A
G
F
CY
-
---
E
AE
I
R
DD
HNR
PLP
A
GE
L
GE
ICI
KGVP
G
K
TI
F
K
E
YF
LN
P
K
A
TA
K
V
L
E
A
D
GW
L
H
T
GD
T
GYR
DEEG
FF
YFV
D
R
R
CN
M
I
K
RGGEN
V
S
CV
E
L
ENI
IA
T
HPKI
Q
D
I
V
VV
G
I
K
D
S
IR
D
E
A
IK
A
F
VVL
N
E
G
-
ET
LS
E
EE
F
F
C
F
-C
EQ
N
M
AKFK
V
P
SY
L
E
IR
K
D
LPR
N
C
SGKI
I
R
K
N
L
fig|749550.3.peg.2549
Escherichia coli MS 200-1 (12-516/517)
M
W
D
D
--
LAD
VY
G
HK
TA
L
I
CE
S
S
S
G
VV
N
--
-
-R
YSY
L
ELNQ
EI
N
R
T
AN
LFYTL
GI
R
K
GD
KV
A
L
H
L
D
N
CP
EF
IFC
W
F
G
L
A
KIGA
IM
VP
I
N
A
R
LL
R
E
E
S
T
W
I
L
QNS
QA
CLLVTS
A
QFYP
MYQ
QI
Q
-
--
--
---
Q
ED
A
S
QL
RH
I
CLT
D
MVLP
A
D
DG
V
S
S
FT
QL
K
N
-
----------
Q
Q
PAT
LC
Y
A
P
P
LST
D
D
T
A
EI
LFTSGTT
S
R
PKGV
VI
TH
Y
N
LRF
A
G
Y
Y
S
AWQ
C
A
L
R
D
D
DVYL
TVM
PA
F
H
IDCQCT
A
AM
A
A
-----
F
S
AGAT
F
VL
VEKY
SA
R
A
F
WG
Q
V
Q
K
Y
R
A
T
I
T
ECI
P
M
M
IR
T
L
M
V
Q
P
L
SAN
D
QQ
H
R
L
RE
V
M
F
Y
L
-
--
-N
LS
EQEK
DA
F
C
E
R
F
S
V
RLL
T
S
YGMTE
TIV
-
G
I
IG
---
-
D
R
P
GD
K
RRWP
S
I
GR
A
G
F
CY
-
---
E
AE
I
R
DD
HNR
PLP
A
GE
L
GE
ICI
KGVP
G
K
TI
F
K
E
YF
LN
P
K
A
TA
K
V
L
E
A
D
GW
L
H
T
GD
T
GYR
DEEG
FF
YFV
D
R
R
CN
M
I
K
RGGEN
V
S
CV
E
L
ENI
IA
T
HPKI
Q
D
I
V
VV
G
I
K
D
S
IR
D
E
A
IK
A
F
VVL
N
E
G
-
ET
LS
E
EE
F
F
C
F
-C
EQ
N
M
AKFK
V
P
SY
L
E
IR
K
D
LPR
N
C
SGKI
I
R
K
N
L
fig|749528.3.peg.2183
Escherichia coli MS 45-1 (12-516/517)
M
W
D
D
--
LAD
VY
G
HK
TA
L
I
CE
S
S
S
G
VV
N
--
-
-R
YSY
L
ELNQ
EI
N
R
T
AN
LFYTL
GI
R
K
GD
KV
A
L
H
L
D
N
CP
EF
IFC
W
F
G
L
A
KIGA
IM
VP
I
N
A
R
LL
R
E
E
S
T
W
I
L
QNS
QA
CLLVTS
A
QFYP
MYQ
QI
Q
-
--
--
---
Q
ED
A
S
QL
RH
I
CLT
D
MVLP
A
D
DG
V
S
S
FT
QL
K
N
-
----------
Q
Q
PAT
LC
Y
A
P
P
LST
D
D
T
A
EI
LFTSGTT
S
R
PKGV
VI
TH
Y
N
LRF
A
G
Y
Y
S
AWQ
C
A
L
R
D
D
DVYL
TVM
PA
F
H
IDCQCT
A
AM
A
A
-----
F
S
AGAT
F
VL
VEKY
SA
R
A
F
WG
Q
V
Q
K
Y
R
A
T
I
T
ECI
P
M
M
IR
T
L
M
V
Q
P
L
SAN
D
QQ
H
R
L
RE
V
M
F
Y
L
-
--
-N
LS
EQEK
DA
F
C
E
R
F
S
V
RLL
T
S
YGMTE
TIV
-
G
I
IG
---
-
D
R
P
GD
K
RRWP
S
I
GR
A
G
F
CY
-
---
E
AE
I
R
DD
HNR
PLP
A
GE
L
GE
ICI
KGVP
G
K
TI
F
K
E
YF
LN
P
K
A
TA
K
V
L
E
A
D
GW
L
H
T
GD
T
GYR
DEEG
FF
YFV
D
R
R
CN
M
I
K
RGGEN
V
S
CV
E
L
ENI
IA
T
HPKI
Q
D
I
V
VV
G
I
K
D
S
IR
D
E
A
IK
A
F
VVL
N
E
G
-
ET
LS
E
EE
F
F
C
F
-C
EQ
N
M
AKFK
V
P
SY
L
E
IR
K
D
LPR
N
C
SGKI
I
R
K
N
L
fig|685038.3.peg.37
Escherichia coli O83:H1 str. NRG 857C (12-516/517)
M
W
D
D
--
LAD
VY
G
HK
TA
L
I
CE
S
S
S
G
VV
N
--
-
-R
YSY
L
ELNQ
EI
N
R
T
AN
LFYTL
GI
R
K
GD
KV
A
L
H
L
D
N
CP
EF
IFC
W
F
G
L
A
KIGA
IM
VP
I
N
A
R
LL
R
E
E
S
T
W
I
L
QNS
QA
CLLVTS
A
QFYP
MYQ
QI
Q
-
--
--
---
Q
ED
A
S
QL
RH
I
CLT
D
MVLP
A
D
DG
V
S
S
FT
QL
K
N
-
----------
Q
Q
PAT
LC
Y
A
P
P
LST
D
D
T
A
EI
LFTSGTT
S
R
PKGV
VI
TH
Y
N
LRF
A
G
Y
Y
S
AWQ
C
A
L
R
D
D
DVYL
TVM
PA
F
H
IDCQCT
A
AM
A
A
-----
F
S
AGAT
F
VL
VEKY
SA
R
A
F
WG
Q
V
Q
K
Y
R
A
T
I
T
ECI
P
M
M
IR
T
L
M
V
Q
P
L
SAN
D
QQ
H
R
L
RE
V
M
F
Y
L
-
--
-N
LS
EQEK
DA
F
C
E
R
F
S
V
RLL
T
S
YGMTE
TIV
-
G
I
IG
---
-
D
R
P
GD
K
RRWP
S
I
GR
A
G
F
CY
-
---
E
AE
I
R
DD
HNR
PLP
A
GE
L
GE
ICI
KGVP
G
K
TI
F
K
E
YF
LN
P
K
A
TA
K
V
L
E
A
D
GW
L
H
T
GD
T
GYR
DEEG
FF
YFV
D
R
R
CN
M
I
K
RGGEN
V
S
CV
E
L
ENI
IA
T
HPKI
Q
D
I
V
VV
G
I
K
D
S
IR
D
E
A
IK
A
F
VVL
N
E
G
-
ET
LS
E
EE
F
F
C
F
-C
EQ
N
M
AKFK
V
P
SY
L
E
IR
K
D
LPR
N
C
SGKI
I
R
K
N
L
fig|562.375.peg.2622
Escherichia coli EC4100B (12-516/517)
M
W
D
D
--
LAD
VY
G
HK
TA
L
I
CE
S
S
GG
VV
N
--
-
-R
YSY
L
ELNQ
EI
N
R
T
AN
LFYTL
GI
R
K
GD
KV
A
L
H
L
D
N
CP
EF
IFC
W
F
G
L
A
KIGA
IM
VP
I
N
A
R
LL
R
E
E
S
A
W
I
L
QNS
QA
CLLVTS
A
QFYP
MYQ
QI
Q
-
--
--
---
Q
ED
A
T
QL
RH
I
CLT
D
VALP
A
D
DG
V
S
S
FT
QL
K
N
-
----------
Q
Q
PAT
LC
Y
A
P
P
LST
D
D
T
A
EI
LFTSGTT
S
R
PKGV
VI
TH
Y
N
LRF
A
G
Y
Y
S
AWQ
C
A
L
R
D
D
DVYL
TVM
PA
F
H
IDCQCT
A
AM
A
A
-----
F
S
AGAT
F
VL
VEKY
SA
R
A
F
WG
Q
V
Q
K
Y
R
A
T
I
T
ECI
P
M
M
IR
T
L
M
V
Q
P
P
SAN
D
RQ
H
R
L
RE
V
M
F
Y
L
-
--
-N
LS
EQEK
DA
F
C
E
R
F
G
V
RLL
T
S
YGMTE
TIV
-
G
I
IG
---
-
D
R
P
GD
K
RRWP
S
I
GR
A
G
F
CY
-
---
E
AE
I
R
DD
HNR
PLP
A
GE
I
GE
ICI
KGVP
G
K
TI
F
K
E
YF
LN
P
K
A
TA
K
V
L
E
A
D
GW
L
H
T
GD
T
GYR
DEEG
FF
YFV
D
R
R
CN
M
I
K
RGGEN
V
S
CV
E
L
ENI
IA
T
HPKI
Q
D
I
V
VV
G
I
K
D
S
IR
D
E
A
IK
A
F
VVL
N
E
G
-
ET
LS
E
EE
F
F
RF
-C
EQ
N
M
AKFK
V
P
SY
L
E
IR
K
D
LPR
N
C
SGKI
I
R
K
N
L
fig|344601.3.peg.4199
Escherichia coli B171 (17-521/522)
M
W
D
D
--
LAD
VY
G
HK
TA
L
I
CE
S
S
GG
VV
N
--
-
-R
YSY
L
ELNQ
EI
N
R
T
AN
LFYTL
GI
R
K
GD
KV
A
L
H
L
D
N
CP
EF
IFC
W
F
G
L
A
KIGA
IM
VP
I
N
A
R
LL
R
E
E
S
A
W
I
L
QNS
QA
CLLVTS
A
QFYP
MYQ
QI
Q
-
--
--
---
Q
ED
A
T
QL
RH
I
CLT
D
VALP
A
D
DG
V
S
S
FT
QL
K
N
-
----------
Q
Q
PAT
LC
Y
A
P
P
LST
D
D
T
A
EI
LFTSGTT
S
R
PKGV
VI
TH
Y
N
LRF
A
G
Y
Y
S
AWQ
C
A
L
R
D
D
DVYL
TVM
PA
F
H
IDCQCT
A
AM
A
A
-----
F
S
AGAT
F
VL
VEKY
SA
R
A
F
WG
Q
V
Q
K
Y
R
A
T
I
T
ECI
P
M
M
IR
T
L
M
V
Q
P
P
SAN
D
RQ
H
R
L
RE
V
M
F
Y
L
-
--
-N
LS
EQEK
DA
F
C
E
R
F
G
V
RLL
T
S
YGMTE
TIV
-
G
I
IG
---
-
D
R
P
GD
K
RRWP
S
I
GR
A
G
F
CY
-
---
E
AE
I
R
DD
HNR
PLP
A
GE
I
GE
ICI
KGVP
G
K
TI
F
K
E
YF
LN
P
K
A
TA
K
V
L
E
A
D
GW
L
H
T
GD
T
GYC
DEEG
FF
YFV
D
R
R
CN
M
I
K
RGGEN
V
S
CV
E
L
ENI
IA
T
HPKI
Q
D
I
V
VV
G
I
K
D
S
IR
D
E
A
IK
A
F
VVL
N
E
G
-
ET
LS
E
EE
F
F
RF
-C
EQ
N
M
AKFK
V
P
SY
L
E
IR
K
D
LPR
N
C
SGKI
I
R
K
N
L
fig|550676.3.peg.4701
Escherichia coli B185 (17-521/522)
M
W
D
D
--
LAD
VY
G
HK
TA
L
I
CE
S
S
GG
VV
N
--
-
-R
YSY
L
ELNQ
EI
N
R
T
AN
LFYTL
GI
R
K
GD
KV
A
L
H
L
D
N
CP
EF
IFC
W
F
G
L
A
KIGA
IM
VP
I
N
A
R
LL
R
E
E
S
A
W
I
L
QNS
QA
CLLVTS
A
QFYP
MYQ
QI
Q
-
--
--
---
Q
ED
A
T
QL
RH
I
CLT
D
VALP
A
D
DG
V
S
S
FT
QL
K
N
-
----------
Q
Q
PAT
LC
Y
A
P
P
LST
D
D
T
A
EI
LFTSGTT
S
R
PKGV
VI
TH
Y
N
LRF
A
G
Y
Y
S
AWQ
C
A
L
R
D
D
DVYL
TVM
PA
F
H
IDCQCT
A
AM
A
A
-----
F
S
AGAT
F
VL
VEKY
SA
R
A
F
WG
Q
V
Q
K
Y
R
A
T
I
T
ECI
P
M
M
IR
T
L
M
V
Q
P
P
SAN
D
RQ
H
R
L
RE
V
M
F
Y
L
-
--
-N
LS
EQEK
DA
F
C
E
R
F
G
V
RLL
T
S
YGMTE
TIV
-
G
I
IG
---
-
D
R
P
GD
K
RRWP
S
I
GR
A
G
F
CY
-
---
E
AE
I
R
DD
HNR
PLP
A
GE
I
GE
ICI
KGVP
G
K
TI
F
K
E
YF
LN
P
K
A
TA
K
V
L
E
A
D
GW
L
H
T
GD
T
GYC
DEEG
FF
YFV
D
R
R
CN
M
I
K
RGGEN
V
S
CV
E
L
ENI
IA
T
HPKI
Q
D
I
V
VV
G
I
K
D
S
IR
D
E
A
IK
A
F
VVL
N
E
G
-
ET
LS
E
EE
F
F
RF
-C
EQ
N
M
AKFK
V
P
SY
L
E
IR
K
D
LPR
N
C
SGKI
I
R
K
N
L
fig|340184.3.peg.4014
Escherichia coli B7A (17-521/522)
M
W
D
D
--
LAD
VY
G
HK
TA
L
I
CE
S
S
GG
VV
N
--
-
-R
YSY
L
ELNQ
EI
N
R
T
AN
LFYTL
GI
R
K
GD
KV
A
L
H
L
D
N
CP
EF
IFC
W
F
G
L
A
KIGA
IM
VP
I
N
A
R
LL
R
E
E
S
A
W
I
L
QNS
QA
CLLVTS
A
QFYP
MYQ
QI
Q
-
--
--
---
Q
ED
A
T
QL
RH
I
CLT
D
VALP
A
D
DG
V
S
S
FT
QL
K
N
-
----------
Q
Q
PAT
LC
Y
A
P
P
LST
D
D
T
A
EI
LFTSGTT
S
R
PKGV
VI
TH
Y
N
LRF
A
G
Y
Y
S
AWQ
C
A
L
R
D
D
DVYL
TVM
PA
F
H
IDCQCT
A
AM
A
A
-----
F
S
AGAT
F
VL
VEKY
SA
R
A
F
WG
Q
V
Q
K
Y
R
A
T
I
T
ECI
P
M
M
IR
T
L
M
V
Q
P
P
SAN
D
RQ
H
R
L
RE
V
M
F
Y
L
-
--
-N
LS
EQEK
DA
F
C
E
R
F
G
V
RLL
T
S
YGMTE
TIV
-
G
I
IG
---
-
D
R
P
GD
K
RRWP
S
I
GR
A
G
F
CY
-
---
E
AE
I
R
DD
HNR
PLP
A
GE
I
GE
ICI
KGVP
G
K
TI
F
K
E
YF
LN
P
K
A
TA
K
V
L
E
A
D
GW
L
H
T
GD
T
GYC
DEEG
FF
YFV
D
R
R
CN
M
I
K
RGGEN
V
S
CV
E
L
ENI
IA
T
HPKI
Q
D
I
V
VV
G
I
K
D
S
IR
D
E
A
IK
A
F
VVL
N
E
G
-
ET
LS
E
EE
F
F
RF
-C
EQ
N
M
AKFK
V
P
SY
L
E
IR
K
D
LPR
N
C
SGKI
I
R
K
N
L
fig|331112.3.peg.37
Escherichia coli HS (17-521/522)
M
W
D
D
--
LAD
VY
G
HK
TA
L
I
CE
S
S
GG
VV
N
--
-
-R
YSY
L
ELNQ
EI
N
R
T
AN
LFYTL
GI
R
K
GD
KV
A
L
H
L
D
N
CP
EF
IFC
W
F
G
L
A
KIGA
IM
VP
I
N
A
R
LL
R
E
E
S
A
W
I
L
QNS
QA
CLLVTS
A
QFYP
MYQ
QI
Q
-
--
--
---
Q
ED
A
T
QL
RH
I
CLT
D
VALP
A
D
DG
V
S
S
FT
QL
K
N
-
----------
Q
Q
PAT
LC
Y
A
P
P
LST
D
D
T
A
EI
LFTSGTT
S
R
PKGV
VI
TH
Y
N
LRF
A
G
Y
Y
S
AWQ
C
A
L
R
D
D
DVYL
TVM
PA
F
H
IDCQCT
A
AM
A
A
-----
F
S
AGAT
F
VL
VEKY
SA
R
A
F
WG
Q
V
Q
K
Y
R
A
T
I
T
ECI
P
M
M
IR
T
L
M
V
Q
P
P
SAN
D
RQ
H
R
L
RE
V
M
F
Y
L
-
--
-N
LS
EQEK
DA
F
C
E
R
F
G
V
RLL
T
S
YGMTE
TIV
-
G
I
IG
---
-
D
R
P
GD
K
RRWP
S
I
GR
A
G
F
CY
-
---
E
AE
I
R
DD
HNR
PLP
A
GE
I
GE
ICI
KGVP
G
K
TI
F
K
E
YF
LN
P
K
A
TA
K
V
L
E
A
D
GW
L
H
T
GD
T
GYC
DEEG
FF
YFV
D
R
R
CN
M
I
K
RGGEN
V
S
CV
E
L
ENI
IA
T
HPKI
Q
D
I
V
VV
G
I
K
D
S
IR
D
E
A
IK
A
F
VVL
N
E
G
-
ET
LS
E
EE
F
F
RF
-C
EQ
N
M
AKFK
V
P
SY
L
E
IR
K
D
LPR
N
C
SGKI
I
R
K
N
L
fig|344601.5.peg.4422
Escherichia coli B171 (12-516/517)
M
W
D
D
--
LAD
VY
G
HK
TA
L
I
CE
S
S
GG
VV
N
--
-
-R
YSY
L
ELNQ
EI
N
R
T
AN
LFYTL
GI
R
K
GD
KV
A
L
H
L
D
N
CP
EF
IFC
W
F
G
L
A
KIGA
IM
VP
I
N
A
R
LL
R
E
E
S
A
W
I
L
QNS
QA
CLLVTS
A
QFYP
MYQ
QI
Q
-
--
--
---
Q
ED
A
T
QL
RH
I
CLT
D
VALP
A
D
DG
V
S
S
FT
QL
K
N
-
----------
Q
Q
PAT
LC
Y
A
P
P
LST
D
D
T
A
EI
LFTSGTT
S
R
PKGV
VI
TH
Y
N
LRF
A
G
Y
Y
S
AWQ
C
A
L
R
D
D
DVYL
TVM
PA
F
H
IDCQCT
A
AM
A
A
-----
F
S
AGAT
F
VL
VEKY
SA
R
A
F
WG
Q
V
Q
K
Y
R
A
T
I
T
ECI
P
M
M
IR
T
L
M
V
Q
P
P
SAN
D
RQ
H
R
L
RE
V
M
F
Y
L
-
--
-N
LS
EQEK
DA
F
C
E
R
F
G
V
RLL
T
S
YGMTE
TIV
-
G
I
IG
---
-
D
R
P
GD
K
RRWP
S
I
GR
A
G
F
CY
-
---
E
AE
I
R
DD
HNR
PLP
A
GE
I
GE
ICI
KGVP
G
K
TI
F
K
E
YF
LN
P
K
A
TA
K
V
L
E
A
D
GW
L
H
T
GD
T
GYC
DEEG
FF
YFV
D
R
R
CN
M
I
K
RGGEN
V
S
CV
E
L
ENI
IA
T
HPKI
Q
D
I
V
VV
G
I
K
D
S
IR
D
E
A
IK
A
F
VVL
N
E
G
-
ET
LS
E
EE
F
F
RF
-C
EQ
N
M
AKFK
V
P
SY
L
E
IR
K
D
LPR
N
C
SGKI
I
R
K
N
L
fig|340184.6.peg.4198
Escherichia coli B7A (12-516/517)
M
W
D
D
--
LAD
VY
G
HK
TA
L
I
CE
S
S
GG
VV
N
--
-
-R
YSY
L
ELNQ
EI
N
R
T
AN
LFYTL
GI
R
K
GD
KV
A
L
H
L
D
N
CP
EF
IFC
W
F
G
L
A
KIGA
IM
VP
I
N
A
R
LL
R
E
E
S
A
W
I
L
QNS
QA
CLLVTS
A
QFYP
MYQ
QI
Q
-
--
--
---
Q
ED
A
T
QL
RH
I
CLT
D
VALP
A
D
DG
V
S
S
FT
QL
K
N
-
----------
Q
Q
PAT
LC
Y
A
P
P
LST
D
D
T
A
EI
LFTSGTT
S
R
PKGV
VI
TH
Y
N
LRF
A
G
Y
Y
S
AWQ
C
A
L
R
D
D
DVYL
TVM
PA
F
H
IDCQCT
A
AM
A
A
-----
F
S
AGAT
F
VL
VEKY
SA
R
A
F
WG
Q
V
Q
K
Y
R
A
T
I
T
ECI
P
M
M
IR
T
L
M
V
Q
P
P
SAN
D
RQ
H
R
L
RE
V
M
F
Y
L
-
--
-N
LS
EQEK
DA
F
C
E
R
F
G
V
RLL
T
S
YGMTE
TIV
-
G
I
IG
---
-
D
R
P
GD
K
RRWP
S
I
GR
A
G
F
CY
-
---
E
AE
I
R
DD
HNR
PLP
A
GE
I
GE
ICI
KGVP
G
K
TI
F
K
E
YF
LN
P
K
A
TA
K
V
L
E
A
D
GW
L
H
T
GD
T
GYC
DEEG
FF
YFV
D
R
R
CN
M
I
K
RGGEN
V
S
CV
E
L
ENI
IA
T
HPKI
Q
D
I
V
VV
G
I
K
D
S
IR
D
E
A
IK
A
F
VVL
N
E
G
-
ET
LS
E
EE
F
F
RF
-C
EQ
N
M
AKFK
V
P
SY
L
E
IR
K
D
LPR
N
C
SGKI
I
R
K
N
L
fig|331112.6.peg.40
Escherichia coli HS (12-516/517)
M
W
D
D
--
LAD
VY
G
HK
TA
L
I
CE
S
S
GG
VV
N
--
-
-R
YSY
L
ELNQ
EI
N
R
T
AN
LFYTL
GI
R
K
GD
KV
A
L
H
L
D
N
CP
EF
IFC
W
F
G
L
A
KIGA
IM
VP
I
N
A
R
LL
R
E
E
S
A
W
I
L
QNS
QA
CLLVTS
A
QFYP
MYQ
QI
Q
-
--
--
---
Q
ED
A
T
QL
RH
I
CLT
D
VALP
A
D
DG
V
S
S
FT
QL
K
N
-
----------
Q
Q
PAT
LC
Y
A
P
P
LST
D
D
T
A
EI
LFTSGTT
S
R
PKGV
VI
TH
Y
N
LRF
A
G
Y
Y
S
AWQ
C
A
L
R
D
D
DVYL
TVM
PA
F
H
IDCQCT
A
AM
A
A
-----
F
S
AGAT
F
VL
VEKY
SA
R
A
F
WG
Q
V
Q
K
Y
R
A
T
I
T
ECI
P
M
M
IR
T
L
M
V
Q
P
P
SAN
D
RQ
H
R
L
RE
V
M
F
Y
L
-
--
-N
LS
EQEK
DA
F
C
E
R
F
G
V
RLL
T
S
YGMTE
TIV
-
G
I
IG
---
-
D
R
P
GD
K
RRWP
S
I
GR
A
G
F
CY
-
---
E
AE
I
R
DD
HNR
PLP
A
GE
I
GE
ICI
KGVP
G
K
TI
F
K
E
YF
LN
P
K
A
TA
K
V
L
E
A
D
GW
L
H
T
GD
T
GYC
DEEG
FF
YFV
D
R
R
CN
M
I
K
RGGEN
V
S
CV
E
L
ENI
IA
T
HPKI
Q
D
I
V
VV
G
I
K
D
S
IR
D
E
A
IK
A
F
VVL
N
E
G
-
ET
LS
E
EE
F
F
RF
-C
EQ
N
M
AKFK
V
P
SY
L
E
IR
K
D
LPR
N
C
SGKI
I
R
K
N
L
fig|679207.4.peg.1072
Escherichia coli MS 107-1 (12-516/517)
M
W
D
D
--
LAD
VY
G
HK
TA
L
I
CE
S
S
GG
VV
N
--
-
-R
YSY
L
ELNQ
EI
N
R
T
AN
LFYTL
GI
R
K
GD
KV
A
L
H
L
D
N
CP
EF
IFC
W
F
G
L
A
KIGA
IM
VP
I
N
A
R
LL
R
E
E
S
A
W
I
L
QNS
QA
CLLVTS
A
QFYP
MYQ
QI
Q
-
--
--
---
Q
ED
A
T
QL
RH
I
CLT
D
VALP
A
D
DG
V
S
S
FT
QL
K
N
-
----------
Q
Q
PAT
LC
Y
A
P
P
LST
D
D
T
A
EI
LFTSGTT
S
R
PKGV
VI
TH
Y
N
LRF
A
G
Y
Y
S
AWQ
C
A
L
R
D
D
DVYL
TVM
PA
F
H
IDCQCT
A
AM
A
A
-----
F
S
AGAT
F
VL
VEKY
SA
R
A
F
WG
Q
V
Q
K
Y
R
A
T
I
T
ECI
P
M
M
IR
T
L
M
V
Q
P
P
SAN
D
RQ
H
R
L
RE
V
M
F
Y
L
-
--
-N
LS
EQEK
DA
F
C
E
R
F
G
V
RLL
T
S
YGMTE
TIV
-
G
I
IG
---
-
D
R
P
GD
K
RRWP
S
I
GR
A
G
F
CY
-
---
E
AE
I
R
DD
HNR
PLP
A
GE
I
GE
ICI
KGVP
G
K
TI
F
K
E
YF
LN
P
K
A
TA
K
V
L
E
A
D
GW
L
H
T
GD
T
GYC
DEEG
FF
YFV
D
R
R
CN
M
I
K
RGGEN
V
S
CV
E
L
ENI
IA
T
HPKI
Q
D
I
V
VV
G
I
K
D
S
IR
D
E
A
IK
A
F
VVL
N
E
G
-
ET
LS
E
EE
F
F
RF
-C
EQ
N
M
AKFK
V
P
SY
L
E
IR
K
D
LPR
N
C
SGKI
I
R
K
N
L
fig|749545.3.peg.2073
Escherichia coli MS 182-1 (12-516/517)
M
W
D
D
--
LAD
VY
G
HK
TA
L
I
CE
S
S
GG
VV
N
--
-
-R
YSY
L
ELNQ
EI
N
R
T
AN
LFYTL
GI
R
K
GD
KV
A
L
H
L
D
N
CP
EF
IFC
W
F
G
L
A
KIGA
IM
VP
I
N
A
R
LL
R
E
E
S
A
W
I
L
QNS
QA
CLLVTS
A
QFYP
MYQ
QI
Q
-
--
--
---
Q
ED
A
T
QL
RH
I
CLT
D
VALP
A
D
DG
V
S
S
FT
QL
K
N
-
----------
Q
Q
PAT
LC
Y
A
P
P
LST
D
D
T
A
EI
LFTSGTT
S
R
PKGV
VI
TH
Y
N
LRF
A
G
Y
Y
S
AWQ
C
A
L
R
D
D
DVYL
TVM
PA
F
H
IDCQCT
A
AM
A
A
-----
F
S
AGAT
F
VL
VEKY
SA
R
A
F
WG
Q
V
Q
K
Y
R
A
T
I
T
ECI
P
M
M
IR
T
L
M
V
Q
P
P
SAN
D
RQ
H
R
L
RE
V
M
F
Y
L
-
--
-N
LS
EQEK
DA
F
C
E
R
F
G
V
RLL
T
S
YGMTE
TIV
-
G
I
IG
---
-
D
R
P
GD
K
RRWP
S
I
GR
A
G
F
CY
-
---
E
AE
I
R
DD
HNR
PLP
A
GE
I
GE
ICI
KGVP
G
K
TI
F
K
E
YF
LN
P
K
A
TA
K
V
L
E
A
D
GW
L
H
T
GD
T
GYC
DEEG
FF
YFV
D
R
R
CN
M
I
K
RGGEN
V
S
CV
E
L
ENI
IA
T
HPKI
Q
D
I
V
VV
G
I
K
D
S
IR
D
E
A
IK
A
F
VVL
N
E
G
-
ET
LS
E
EE
F
F
RF
-C
EQ
N
M
AKFK
V
P
SY
L
E
IR
K
D
LPR
N
C
SGKI
I
R
K
N
L
fig|749532.3.peg.4232
Escherichia coli MS 78-1 (12-516/517)
M
W
D
D
--
LAD
VY
G
HK
TA
L
I
CE
S
S
GG
VV
N
--
-
-R
YSY
L
ELNQ
EI
N
R
T
AN
LFYTL
GI
R
K
GD
KV
A
L
H
L
D
N
CP
EF
IFC
W
F
G
L
A
KIGA
IM
VP
I
N
A
R
LL
R
E
E
S
A
W
I
L
QNS
QA
CLLVTS
A
QFYP
MYQ
QI
Q
-
--
--
---
Q
ED
A
T
QL
RH
I
CLT
D
VALP
A
D
DG
V
S
S
FT
QL
K
N
-
----------
Q
Q
PAT
LC
Y
A
P
P
LST
D
D
T
A
EI
LFTSGTT
S
R
PKGV
VI
TH
Y
N
LRF
A
G
Y
Y
S
AWQ
C
A
L
R
D
D
DVYL
TVM
PA
F
H
IDCQCT
A
AM
A
A
-----
F
S
AGAT
F
VL
VEKY
SA
R
A
F
WG
Q
V
Q
K
Y
R
A
T
I
T
ECI
P
M
M
IR
T
L
M
V
Q
P
P
SAN
D
RQ
H
R
L
RE
V
M
F
Y
L
-
--
-N
LS
EQEK
DA
F
C
E
R
F
G
V
RLL
T
S
YGMTE
TIV
-
G
I
IG
---
-
D
R
P
GD
K
RRWP
S
I
GR
A
G
F
CY
-
---
E
AE
I
R
DD
HNR
PLP
A
GE
I
GE
ICI
KGVP
G
K
TI
F
K
E
YF
LN
P
K
A
TA
K
V
L
E
A
D
GW
L
H
T
GD
T
GYC
DEEG
FF
YFV
D
R
R
CN
M
I
K
RGGEN
V
S
CV
E
L
ENI
IA
T
HPKI
Q
D
I
V
VV
G
I
K
D
S
IR
D
E
A
IK
A
F
VVL
N
E
G
-
ET
LS
E
EE
F
F
RF
-C
EQ
N
M
AKFK
V
P
SY
L
E
IR
K
D
LPR
N
C
SGKI
I
R
K
N
L
fig|701177.3.peg.38
Escherichia coli O55:H7 str. CB9615 (12-516/517)
M
W
D
D
--
LAD
VY
G
HK
TA
L
I
CE
S
S
GG
VV
N
--
-
-R
YSY
L
ELNQ
EI
N
R
T
AN
LFYTL
GI
R
K
GD
KV
A
L
H
L
D
N
CP
EF
IFC
W
F
G
L
A
KIGA
IM
VP
I
N
A
R
LL
R
E
E
S
A
W
I
L
QNS
QA
CLLVTS
A
QFYP
MYQ
QI
Q
-
--
--
---
Q
ED
A
T
QL
RH
I
CLT
D
VALP
A
D
DG
V
S
S
FT
QL
K
N
-
----------
Q
Q
PAT
LC
Y
A
P
P
LST
D
D
T
A
EI
LFTSGTT
S
R
PKGV
VI
TH
Y
N
LRF
A
G
Y
Y
S
AWQ
C
A
L
R
D
D
DVYL
TVM
PA
F
H
IDCQCT
A
AM
A
A
-----
F
S
AGAT
F
VL
VEKY
SA
R
A
F
WG
Q
V
Q
K
Y
R
A
T
I
T
ECI
P
M
M
IR
T
L
M
V
Q
P
P
SAN
D
RQ
H
R
L
RE
V
M
F
Y
L
-
--
-N
LS
EQEK
D
T
F
C
E
R
F
G
V
RLL
T
S
YGMTE
TIV
-
G
I
IG
---
-
D
R
P
GD
K
RRWP
S
I
GR
A
G
F
CY
-
---
E
AE
I
R
DD
HNR
PLP
A
GE
I
GE
ICI
KGVP
G
K
TI
F
K
E
YF
LN
P
K
A
TA
K
V
L
E
A
D
GW
L
H
T
GD
T
GYR
DEEG
FF
YFI
D
R
R
CN
M
I
K
RGGEN
V
S
CV
E
L
ENI
IA
T
HPKI
Q
D
I
V
VV
G
I
K
D
S
IR
D
E
A
IK
A
F
VVL
N
E
G
-
ET
LS
E
EE
F
F
RF
-C
EQ
N
M
AKFK
V
P
SY
L
E
IR
K
D
LPR
N
C
SGKI
I
R
K
N
L
fig|550677.3.peg.421
Escherichia coli B354 (17-521/522)
M
W
D
D
--
LAD
VY
G
HK
TA
L
I
CE
S
S
S
G
VV
N
--
-
-R
YSY
L
ELNQ
EI
N
R
T
AN
LFYTL
GI
R
K
GD
KV
A
L
H
L
D
N
CP
EF
IFC
W
F
G
L
A
KIGA
IM
VP
I
N
A
R
LL
R
E
E
S
A
W
I
L
QNS
QA
CLLVTS
A
QFYP
MYQ
QI
Q
-
--
--
---
Q
ED
A
S
QL
RH
I
CLI
D
MALP
A
D
DG
V
S
S
FT
QL
K
N
-
----------
Q
Q
PAT
LC
Y
A
P
P
LST
D
D
T
A
EI
LFTSGTT
S
R
PKGV
VI
TH
Y
N
LRF
A
G
Y
Y
S
AWQ
C
A
L
R
D
D
DVYL
TVM
PA
F
H
IDCQCT
A
AM
A
A
-----
F
S
AGAT
F
VL
VEKY
SA
R
A
F
WG
Q
V
Q
K
Y
R
A
T
I
T
ECI
P
M
M
IR
T
L
M
V
Q
P
P
SAN
D
RQ
H
C
L
RE
V
M
F
Y
L
-
--
-N
LS
EQEK
DA
F
C
E
R
F
S
V
RLL
T
S
YGMTE
TIV
-
G
I
IG
---
-
D
R
P
GD
K
RRWP
S
I
GR
A
G
F
CY
-
---
E
AE
I
R
DD
HNR
PLP
A
GE
L
GE
ICI
KGVP
G
K
TI
F
K
E
YF
LN
P
K
A
TA
K
V
L
E
A
D
GW
L
H
T
GD
T
GYR
DEEG
FF
YFV
D
R
R
CN
M
I
K
RGGEN
V
S
CV
E
L
ENI
IA
T
HPKI
Q
D
I
V
VV
G
I
K
D
S
IR
D
E
A
IK
A
F
VVL
N
E
G
-
ET
LS
E
EE
F
F
RF
-C
EQ
N
M
AKFK
V
P
SY
L
E
IR
K
D
LPR
N
C
SGKI
I
R
K
N
L
fig|656380.3.peg.212
Escherichia coli FVEC1412 (12-516/517)
M
W
D
D
--
LAD
VY
G
HK
TA
L
I
CE
S
S
S
G
VV
N
--
-
-R
YSY
L
ELNQ
EI
N
R
T
AN
LFYTL
GI
R
K
GD
KV
A
L
H
L
D
N
CP
EF
IFC
W
F
G
L
A
KIGA
IM
VP
I
N
A
R
LL
R
E
E
S
A
W
I
L
QNS
QA
CLLVTS
A
QFYP
MYQ
QI
Q
-
--
--
---
Q
ED
A
S
QL
RH
I
CLI
D
MALP
A
D
DG
V
S
S
FT
QL
K
N
-
----------
Q
Q
PAT
LC
Y
A
P
P
LST
D
D
T
A
EI
LFTSGTT
S
R
PKGV
VI
TH
Y
N
LRF
A
G
Y
Y
S
AWQ
C
A
L
R
D
D
DVYL
TVM
PA
F
H
IDCQCT
A
AM
A
A
-----
F
S
AGAT
F
VL
VEKY
SA
R
A
F
WG
Q
V
Q
K
Y
R
A
T
I
T
ECI
P
M
M
IR
T
L
M
V
Q
P
P
SAN
D
RQ
H
C
L
RE
V
M
F
Y
L
-
--
-N
LS
EQEK
DA
F
C
E
R
F
S
V
RLL
T
S
YGMTE
TIV
-
G
I
IG
---
-
D
R
P
GD
K
RRWP
S
I
GR
A
G
F
CY
-
---
E
AE
I
R
DD
HNR
PLP
A
GE
L
GE
ICI
KGVP
G
K
TI
F
K
E
YF
LN
P
K
A
TA
K
V
L
E
A
D
GW
L
H
T
GD
T
GYR
DEEG
FF
YFV
D
R
R
CN
M
I
K
RGGEN
V
S
CV
E
L
ENI
IA
A
HPKI
Q
D
I
V
VV
G
I
K
D
S
IR
D
E
A
IK
A
F
VVL
N
E
G
-
ET
LS
E
EE
F
F
RF
-C
EQ
N
M
AKFK
V
P
SY
L
E
IR
K
D
LPR
N
C
SGKI
I
R
K
N
L
fig|749549.3.peg.4618
Escherichia coli MS 198-1 (12-516/517)
M
W
D
D
--
LAD
VY
G
HK
TA
L
I
CE
S
S
S
G
VV
N
--
-
-R
YSY
L
ELNQ
EI
N
R
T
AN
LFYTL
GI
R
K
GD
KV
A
L
H
L
D
N
CP
EF
IFC
W
F
G
L
A
KIGA
IM
VP
I
N
A
R
LL
R
E
E
S
A
W
I
L
QNS
QA
CLLVTS
A
QFYP
MYQ
QI
Q
-
--
--
---
Q
ED
A
S
QL
RH
I
CLI
D
MALP
A
D
DG
V
S
S
FT
QL
K
N
-
----------
Q
Q
PAT
LC
Y
A
P
P
LST
D
D
T
A
EI
LFTSGTT
S
R
PKGV
VI
TH
Y
N
LRF
A
G
Y
Y
S
AWQ
C
A
L
R
D
D
DVYL
TVM
PA
F
H
IDCQCT
A
AM
A
A
-----
F
S
AGAT
F
VL
VEKY
SA
R
A
F
WG
Q
V
Q
K
Y
R
A
T
I
T
ECI
P
M
M
IR
T
L
M
V
Q
P
P
SAN
D
RQ
H
C
L
RE
V
M
F
Y
L
-
--
-N
LS
EQEK
DA
F
C
E
R
F
S
V
RLL
T
S
YGMTE
TIV
-
G
I
IG
---
-
D
R
P
GD
K
RRWP
S
I
GR
A
G
F
CY
-
---
E
AE
I
R
DD
HNR
PLP
A
GE
L
GE
ICI
KGVP
G
K
TI
F
K
E
YF
LN
P
K
A
TA
K
V
L
E
A
D
GW
L
H
T
GD
T
GYR
DEEG
FF
YFV
D
R
R
CN
M
I
K
RGGEN
V
S
CV
E
L
ENI
IA
A
HPKI
Q
D
I
V
VV
G
I
K
D
S
IR
D
E
A
IK
A
F
VVL
N
E
G
-
ET
LS
E
EE
F
F
RF
-C
EQ
N
M
AKFK
V
P
SY
L
E
IR
K
D
LPR
N
C
SGKI
I
R
K
N
L
fig|656444.3.peg.364
Escherichia coli TA280 (12-516/517)
M
W
D
D
--
LAD
VY
G
HK
TA
L
I
CE
S
S
S
G
VV
N
--
-
-R
YSY
L
ELNQ
EI
N
R
T
AN
LFYTL
GI
R
K
GD
KV
A
L
H
L
D
N
CP
EF
IFC
W
F
G
L
A
KIGA
IM
VP
I
N
A
R
LL
R
E
E
S
A
W
I
L
QNS
QA
CLLVTS
A
QFYP
MYQ
QI
Q
-
--
--
---
Q
ED
A
S
QL
RH
I
CLI
D
MALP
A
D
DG
V
S
S
FT
QL
K
N
-
----------
Q
Q
PAT
LC
Y
A
P
P
LST
D
D
T
A
EI
LFTSGTT
S
R
PKGV
VI
TH
Y
N
LRF
A
G
Y
Y
S
AWQ
C
A
L
R
D
D
DVYL
TVM
PA
F
H
IDCQCT
A
AM
A
A
-----
F
S
AGAT
F
VL
VEKY
SA
R
A
F
WG
Q
V
Q
K
Y
R
A
T
I
T
ECI
P
M
M
IR
T
L
M
V
Q
P
P
SAN
D
RQ
H
C
L
RE
V
M
F
Y
L
-
--
-N
LS
EQEK
DA
F
C
E
R
F
S
V
RLL
T
S
YGMTE
TIV
-
G
I
IG
---
-
D
R
P
GD
K
RRWP
S
I
GR
A
G
F
CY
-
---
E
AE
I
R
DD
HNR
PLP
A
GE
L
GE
ICI
KGVP
G
K
TI
F
K
E
YF
LN
P
K
A
TA
K
V
L
E
A
D
GW
L
H
T
GD
T
GYR
DEEG
FF
YFV
D
R
R
CN
M
I
K
RGGEN
V
S
CV
E
L
ENI
IA
A
HPKI
Q
D
I
V
VV
G
I
K
D
S
IR
D
E
A
IK
A
F
VVL
N
E
G
-
ET
LS
E
EE
F
F
RF
-C
EQ
N
M
AKFK
V
P
SY
L
E
IR
K
D
LPR
N
C
SGKI
I
R
K
N
L
fig|585056.7.peg.224
Escherichia coli UMN026 (12-516/517)
M
W
D
D
--
LAD
VY
G
HK
TA
L
I
CE
S
S
S
G
VV
N
--
-
-R
YSY
L
ELNQ
EI
N
R
T
AN
LFYTL
GI
R
K
GD
KV
A
L
H
L
D
N
CP
EF
IFC
W
F
G
L
A
KIGA
IM
VP
I
N
A
R
LL
R
E
E
S
A
W
I
L
QNS
QA
CLLVTS
A
QFYP
MYQ
QI
Q
-
--
--
---
Q
ED
A
S
QL
RH
I
CLI
D
MALP
A
D
DG
V
S
S
FT
QL
K
N
-
----------
Q
Q
PAT
LC
Y
A
P
P
LST
D
D
T
A
EI
LFTSGTT
S
R
PKGV
VI
TH
Y
N
LRF
A
G
Y
Y
S
AWQ
C
A
L
R
D
D
DVYL
TVM
PA
F
H
IDCQCT
A
AM
A
A
-----
F
S
AGAT
F
VL
VEKY
SA
R
A
F
WG
Q
V
Q
K
Y
R
A
T
I
T
ECI
P
M
M
IR
T
L
M
V
Q
P
P
SAN
D
RQ
H
C
L
RE
V
M
F
Y
L
-
--
-N
LS
EQEK
DA
F
C
E
R
F
S
V
RLL
T
S
YGMTE
TIV
-
G
I
IG
---
-
D
R
P
GD
K
RRWP
S
I
GR
A
G
F
CY
-
---
E
AE
I
R
DD
HNR
PLP
A
GE
L
GE
ICI
KGVP
G
K
TI
F
K
E
YF
LN
P
K
A
TA
K
V
L
E
A
D
GW
L
H
T
GD
T
GYR
DEEG
FF
YFV
D
R
R
CN
M
I
K
RGGEN
V
S
CV
E
L
ENI
IA
A
HPKI
Q
D
I
V
VV
G
I
K
D
S
IR
D
E
A
IK
A
F
VVL
N
E
G
-
ET
LS
E
EE
F
F
RF
-C
EQ
N
M
AKFK
V
P
SY
L
E
IR
K
D
LPR
N
C
SGKI
I
R
K
N
L
fig|656437.3.peg.91
Escherichia coli TA143 (12-516/517)
M
W
D
D
--
LAD
VY
G
HK
TA
L
I
CE
S
S
S
G
VV
N
--
-
-R
YSY
L
ELNQ
EI
N
R
T
AN
LFYTL
GI
R
K
GD
KV
A
L
H
L
D
N
CP
EF
IFC
W
F
G
L
A
KIGA
IM
VP
I
N
A
R
LL
R
E
E
S
T
W
I
L
QNS
QA
CLLVTS
A
QFYP
MYQ
QI
Q
-
--
--
---
Q
ED
A
S
QL
RH
I
CLT
D
MVLP
A
D
DG
V
S
S
FT
QL
K
N
-
----------
Q
Q
PAT
LC
Y
A
P
P
LST
D
D
T
A
EI
LFTSGTT
S
R
PKGV
VI
TH
Y
N
LRF
A
G
Y
Y
S
AWQ
C
A
L
R
D
D
DVYL
TVM
PA
F
H
IDCQCT
A
AM
A
A
-----
F
S
AGAT
F
VL
VEKY
SA
R
A
F
WG
Q
V
Q
K
Y
R
A
T
I
T
ECI
P
M
M
IR
T
L
M
V
Q
P
P
SAN
D
RQ
H
C
L
RE
V
M
F
Y
L
-
--
-N
LS
EQEK
DA
F
C
E
R
F
S
V
RLL
T
S
YGMTE
TIV
-
G
I
IG
---
-
D
R
P
GD
K
RRWP
S
I
GR
A
G
F
CY
-
---
E
AE
I
R
DD
HNR
PLP
A
GE
L
GE
ICI
KGVP
G
K
TI
F
K
E
YF
LN
P
K
A
TA
K
V
L
E
A
D
GW
L
H
T
GD
T
GYR
DEEG
FF
YFV
D
R
R
CN
M
I
K
RGGEN
V
S
CV
E
L
ENI
IA
T
HPKI
Q
D
I
V
VV
G
I
K
D
S
IR
D
E
A
IK
A
F
VVL
N
E
G
-
ET
LS
E
EE
F
F
RF
-C
EQ
N
M
AKFK
V
P
SY
L
E
IR
K
D
LPR
N
C
SGKI
I
R
K
N
L
fig|679205.4.peg.3551
Escherichia coli MS 124-1 (12-516/517)
M
W
D
D
--
LAD
VY
G
HK
TA
L
I
CE
S
S
GG
VV
N
--
-
-R
YSY
L
ELNQ
EI
N
R
T
AN
LFYTL
GI
R
K
GD
KV
A
L
H
L
D
N
CP
EF
IFC
W
F
G
L
A
KIGA
IM
VP
I
N
A
R
LL
R
E
E
S
A
W
I
L
QNS
QA
CLLVTS
A
QFYP
MYQ
QI
Q
-
--
--
---
Q
ED
A
T
QL
RH
I
CLT
D
VALP
A
D
DG
V
S
S
FT
QL
K
N
-
----------
Q
Q
PAT
LC
Y
A
P
P
LLT
D
D
T
A
EI
LFTSGTT
S
R
PKGV
VI
TH
Y
N
LRF
A
G
Y
Y
S
AWQ
C
A
L
R
D
D
DVYL
TVM
PA
F
H
IDCQCT
A
AM
A
A
-----
F
S
AGAT
F
VL
VEKY
SA
R
A
F
WG
Q
V
Q
K
Y
R
A
T
I
T
ECI
P
M
M
IR
T
L
M
V
Q
P
P
SAN
D
RQ
H
R
L
RE
V
M
F
Y
L
-
--
-N
LS
EQEK
DA
F
C
E
R
F
G
V
RLL
T
S
YGMTE
TIV
-
G
I
IG
---
-
D
R
P
GD
K
RRWP
S
I
GR
A
G
F
CY
-
---
E
AE
I
R
DD
HNR
PLP
A
GE
I
GE
ICI
KGVP
G
K
TI
F
K
E
YF
LN
P
K
A
TA
K
V
L
E
A
D
GW
L
H
T
GD
T
GYC
DEEG
FF
YFV
D
R
R
CN
M
I
K
RGGEN
V
S
CV
E
L
ENI
IA
T
HPKI
Q
D
I
V
VV
G
I
K
D
S
IR
D
E
A
IK
A
F
VVL
N
E
G
-
ET
LS
E
EE
F
F
RF
-C
EQ
N
M
AKFK
V
P
SY
L
E
IR
K
D
LPR
N
C
SGKI
I
R
K
N
L
fig|749533.3.peg.3318
Escherichia coli MS 84-1 (12-516/517)
M
W
D
D
--
LAD
VY
G
HK
TA
L
I
CE
S
S
GG
VV
N
--
-
-R
YSY
L
ELNQ
EI
N
R
T
AN
LFYTL
GI
R
K
GD
KV
A
L
H
L
D
N
CP
EF
IFC
W
F
G
L
A
KIGA
IM
VP
I
N
A
R
LL
R
E
E
S
A
W
I
L
QNS
QA
CLLVTS
A
QFYP
MYQ
QI
Q
-
--
--
---
Q
ED
A
T
QL
RH
I
CLT
D
VALP
A
D
DG
V
S
S
FT
QL
K
N
-
----------
Q
Q
PAT
LC
Y
A
P
P
LLT
D
D
T
A
EI
LFTSGTT
S
R
PKGV
VI
TH
Y
N
LRF
A
G
Y
Y
S
AWQ
C
A
L
R
D
D
DVYL
TVM
PA
F
H
IDCQCT
A
AM
A
A
-----
F
S
AGAT
F
VL
VEKY
SA
R
A
F
WG
Q
V
Q
K
Y
R
A
T
I
T
ECI
P
M
M
IR
T
L
M
V
Q
P
P
SAN
D
RQ
H
R
L
RE
V
M
F
Y
L
-
--
-N
LS
EQEK
DA
F
C
E
R
F
G
V
RLL
T
S
YGMTE
TIV
-
G
I
IG
---
-
D
R
P
GD
K
RRWP
S
I
GR
A
G
F
CY
-
---
E
AE
I
R
DD
HNR
PLP
A
GE
I
GE
ICI
KGVP
G
K
TI
F
K
E
YF
LN
P
K
A
TA
K
V
L
E
A
D
GW
L
H
T
GD
T
GYC
DEEG
FF
YFV
D
R
R
CN
M
I
K
RGGEN
V
S
CV
E
L
ENI
IA
T
HPKI
Q
D
I
V
VV
G
I
K
D
S
IR
D
E
A
IK
A
F
VVL
N
E
G
-
ET
LS
E
EE
F
F
RF
-C
EQ
N
M
AKFK
V
P
SY
L
E
IR
K
D
LPR
N
C
SGKI
I
R
K
N
L
fig|585396.4.peg.36
Escherichia coli O111:H- str. 11128 (12-516/517)
M
W
D
D
--
LAD
VY
G
HK
TA
L
I
CE
S
S
GG
VV
N
--
-
-R
YSY
L
ELNQ
EI
N
R
T
AN
LFYTL
GI
R
K
GD
KV
A
L
H
L
D
N
CP
EF
IFC
W
F
G
L
A
KIGA
IM
VP
I
N
A
R
LL
R
E
E
S
A
W
I
L
QNS
QA
CLLVTS
A
QFYP
MYQ
QI
Q
-
--
--
---
Q
ED
A
T
QL
RH
I
CLT
D
VALP
A
D
DG
V
S
S
FT
QL
K
N
-
----------
Q
Q
PAT
LC
Y
A
P
P
LLT
D
D
T
A
EI
LFTSGTT
S
R
PKGV
VI
TH
Y
N
LRF
A
G
Y
Y
S
AWQ
C
A
L
R
D
D
DVYL
TVM
PA
F
H
IDCQCT
A
AM
A
A
-----
F
S
AGAT
F
VL
VEKY
SA
R
A
F
WG
Q
V
Q
K
Y
R
A
T
I
T
ECI
P
M
M
IR
T
L
M
V
Q
P
P
SAN
D
RQ
H
R
L
RE
V
M
F
Y
L
-
--
-N
LS
EQEK
DA
F
C
E
R
F
G
V
RLL
T
S
YGMTE
TIV
-
G
I
IG
---
-
D
R
P
GD
K
RRWP
S
I
GR
A
G
F
CY
-
---
E
AE
I
R
DD
HNR
PLP
A
GE
I
GE
ICI
KGVP
G
K
TI
F
K
E
YF
LN
P
K
A
TA
K
V
L
E
A
D
GW
L
H
T
GD
T
GYC
DEEG
FF
YFV
D
R
R
CN
M
I
K
RGGEN
V
S
CV
E
L
ENI
IA
T
HPKI
Q
D
I
V
VV
G
I
K
D
S
IR
D
E
A
IK
A
F
VVL
N
E
G
-
ET
LS
E
EE
F
F
RF
-C
EQ
N
M
AKFK
V
P
SY
L
E
IR
K
D
LPR
N
C
SGKI
I
R
K
N
L
fig|573235.3.peg.37
Escherichia coli O26:H11 str. 11368 (12-516/517)
M
W
D
D
--
LAD
VY
G
HK
TA
L
I
CE
S
S
GG
VV
N
--
-
-R
YSY
L
ELNQ
EI
N
R
T
AN
LFYTL
GI
R
K
GD
KV
A
L
H
L
D
N
CP
EF
IFC
W
F
G
L
A
KIGA
IM
VP
I
N
A
R
LL
R
E
E
S
A
W
I
L
QNS
QA
CLLVTS
A
QFYP
MYQ
QI
Q
-
--
--
---
Q
ED
A
T
QL
RH
I
CLT
D
VALP
A
D
DG
V
S
S
FT
QL
K
N
-
----------
Q
Q
PAT
LC
Y
A
P
P
LLT
D
D
T
A
EI
LFTSGTT
S
R
PKGV
VI
TH
Y
N
LRF
A
G
Y
Y
S
AWQ
C
A
L
R
D
D
DVYL
TVM
PA
F
H
IDCQCT
A
AM
A
A
-----
F
S
AGAT
F
VL
VEKY
SA
R
A
F
WG
Q
V
Q
K
Y
R
A
T
I
T
ECI
P
M
M
IR
T
L
M
V
Q
P
P
SAN
D
RQ
H
R
L
RE
V
M
F
Y
L
-
--
-N
LS
EQEK
DA
F
C
E
R
F
G
V
RLL
T
S
YGMTE
TIV
-
G
I
IG
---
-
D
R
P
GD
K
RRWP
S
I
GR
A
G
F
CY
-
---
E
AE
I
R
DD
HNR
PLP
A
GE
I
GE
ICI
KGVP
G
K
TI
F
K
E
YF
LN
P
K
A
TA
K
V
L
E
A
D
GW
L
H
T
GD
T
GYC
DEEG
FF
YFV
D
R
R
CN
M
I
K
RGGEN
V
S
CV
E
L
ENI
IA
T
HPKI
Q
D
I
V
VV
G
I
K
D
S
IR
D
E
A
IK
A
F
VVL
N
E
G
-
ET
LS
E
EE
F
F
RF
-C
EQ
N
M
AKFK
V
P
SY
L
E
IR
K
D
LPR
N
C
SGKI
I
R
K
N
L
fig|409438.11.peg.153
Escherichia coli SE11 (12-516/517)
M
W
D
D
--
LAD
VY
G
HK
TA
L
I
CE
S
S
GG
VV
N
--
-
-R
YSY
L
ELNQ
EI
N
R
T
AN
LFYTL
GI
R
K
GD
KV
A
L
H
L
D
N
CP
EF
IFC
W
F
G
L
A
KIGA
IM
VP
I
N
A
R
LL
R
E
E
S
A
W
I
L
QNS
QA
CLLVTS
A
QFYP
MYQ
QI
Q
-
--
--
---
Q
ED
A
T
QL
RH
I
CLT
D
VALP
A
D
DG
V
S
S
FT
QL
K
N
-
----------
Q
Q
PAT
LC
Y
A
P
P
LLT
D
D
T
A
EI
LFTSGTT
S
R
PKGV
VI
TH
Y
N
LRF
A
G
Y
Y
S
AWQ
C
A
L
R
D
D
DVYL
TVM
PA
F
H
IDCQCT
A
AM
A
A
-----
F
S
AGAT
F
VL
VEKY
SA
R
A
F
WG
Q
V
Q
K
Y
R
A
T
I
T
ECI
P
M
M
IR
T
L
M
V
Q
P
P
SAN
D
RQ
H
R
L
RE
V
M
F
Y
L
-
--
-N
LS
EQEK
DA
F
C
E
R
F
G
V
RLL
T
S
YGMTE
TIV
-
G
I
IG
---
-
D
R
P
GD
K
RRWP
S
I
GR
A
G
F
CY
-
---
E
AE
I
R
DD
HNR
PLP
A
GE
I
GE
ICI
KGVP
G
K
TI
F
K
E
YF
LN
P
K
A
TA
K
V
L
E
A
D
GW
L
H
T
GD
T
GYC
DEEG
FF
YFV
D
R
R
CN
M
I
K
RGGEN
V
S
CV
E
L
ENI
IA
T
HPKI
Q
D
I
V
VV
G
I
K
D
S
IR
D
E
A
IK
A
F
VVL
N
E
G
-
ET
LS
E
EE
F
F
RF
-C
EQ
N
M
AKFK
V
P
SY
L
E
IR
K
D
LPR
N
C
SGKI
I
R
K
N
L
fig|656440.3.peg.5091
Escherichia coli TA206 (12-516/517)
M
W
D
D
--
LAD
VY
G
HK
TA
L
I
CE
S
S
S
G
VV
N
--
-
-R
YSY
L
ELNQ
EI
N
R
T
AN
LFYVL
GI
R
K
GD
KV
A
L
H
L
D
N
CP
EF
IFC
W
F
G
L
A
KIGA
IM
VP
I
N
A
R
LL
R
E
E
S
T
W
I
L
QNS
QA
CLLVTS
A
QFYP
MYQ
QI
Q
-
--
--
---
Q
ED
A
S
QL
RH
I
CLT
D
MALP
A
D
DG
V
S
S
FT
QL
K
N
-
----------
Q
Q
PAT
LC
Y
A
P
P
LST
D
D
T
A
EI
LFTSGTT
S
R
PKGV
VI
TH
Y
N
LRF
A
G
Y
Y
S
AWQ
C
A
L
R
D
D
DVYL
TVM
PA
F
H
IDCQCT
A
AM
A
A
-----
F
S
AGAT
F
VL
VEKY
SA
R
A
F
WG
Q
V
Q
K
Y
R
A
T
I
T
ECI
P
M
M
IR
T
L
M
V
Q
P
L
SAN
D
QQ
H
R
L
RE
V
M
F
Y
L
-
--
-N
LS
EQEK
DA
F
C
E
R
F
S
V
RLL
T
S
YGMTE
TIV
-
G
I
IG
---
-
D
R
P
GD
K
RRWP
S
I
GR
A
G
F
CY
-
---
E
AE
I
R
DD
HNR
PLP
A
GE
L
GE
ICI
KGVP
G
K
TI
F
K
E
YF
LN
P
K
A
TA
K
V
L
E
A
D
GW
L
H
T
GD
T
GYR
DEEG
FF
YFV
D
R
R
CN
M
I
K
RGGEN
V
S
CV
E
L
ENI
IA
T
HPKI
Q
D
I
V
VV
G
I
K
D
S
IR
D
E
A
IK
A
F
VVL
N
E
G
-
ET
LS
E
EE
F
F
C
F
-C
EQ
N
M
AKFK
V
P
SY
L
E
IR
K
D
LPR
N
C
SGKI
I
R
K
N
L
fig|331111.3.peg.2610
Escherichia coli E24377A (17-521/522)
M
W
D
D
--
LAD
VY
G
HK
TA
L
I
CE
S
S
GG
VV
N
--
-
-R
YSY
L
ELNQ
EI
N
R
T
AN
LFYTL
GI
R
K
GD
KV
A
L
H
L
D
N
CP
EF
IFC
W
F
G
L
A
KIGA
IM
VP
I
N
A
R
LL
R
E
E
S
A
W
I
L
QNS
QA
CLLVTS
A
QFYP
MYQ
QI
Q
-
--
--
---
Q
ED
A
T
QL
RH
I
CLT
D
VALP
A
D
DG
V
S
S
FT
QL
K
N
-
----------
Q
Q
PAT
LC
Y
A
P
P
LST
D
D
T
A
EI
LFTSGTT
S
R
PKGV
VI
TH
Y
N
LRF
A
G
Y
Y
S
AWQ
C
A
L
R
D
D
DVYL
TVM
PA
F
H
IDCQCT
A
AM
A
A
-----
F
S
AGAT
F
VL
VEKY
SA
R
A
F
WG
Q
A
Q
K
Y
R
A
T
I
T
ECI
P
M
M
IR
T
L
M
V
Q
P
P
SAN
D
RQ
H
R
L
RE
V
M
F
Y
L
-
--
-N
LS
EQEK
DA
F
C
E
R
F
G
V
RLL
T
S
YGMTE
TIV
-
G
I
IG
---
-
D
R
P
GD
K
RRWP
S
I
GR
A
G
F
CY
-
---
E
AE
I
R
DD
HNR
PLP
A
GE
I
GE
ICI
KGVP
G
K
TI
F
K
E
YF
LN
P
K
A
TA
K
V
L
E
A
D
GW
L
H
T
GD
T
GYC
DEEG
FF
YFV
D
R
R
CN
M
I
K
RGGEN
V
S
CV
E
L
ENI
IA
T
HPKI
Q
D
I
V
VV
G
I
K
D
S
IR
D
E
A
IK
A
F
VVL
N
E
G
-
ET
LS
E
EE
F
F
RF
-C
EQ
N
M
AKFK
V
P
SY
L
E
IR
K
D
LPR
N
C
SGKI
I
R
K
N
L
fig|331111.12.peg.368
Escherichia coli E24377A (12-516/517)
M
W
D
D
--
LAD
VY
G
HK
TA
L
I
CE
S
S
GG
VV
N
--
-
-R
YSY
L
ELNQ
EI
N
R
T
AN
LFYTL
GI
R
K
GD
KV
A
L
H
L
D
N
CP
EF
IFC
W
F
G
L
A
KIGA
IM
VP
I
N
A
R
LL
R
E
E
S
A
W
I
L
QNS
QA
CLLVTS
A
QFYP
MYQ
QI
Q
-
--
--
---
Q
ED
A
T
QL
RH
I
CLT
D
VALP
A
D
DG
V
S
S
FT
QL
K
N
-
----------
Q
Q
PAT
LC
Y
A
P
P
LST
D
D
T
A
EI
LFTSGTT
S
R
PKGV
VI
TH
Y
N
LRF
A
G
Y
Y
S
AWQ
C
A
L
R
D
D
DVYL
TVM
PA
F
H
IDCQCT
A
AM
A
A
-----
F
S
AGAT
F
VL
VEKY
SA
R
A
F
WG
Q
A
Q
K
Y
R
A
T
I
T
ECI
P
M
M
IR
T
L
M
V
Q
P
P
SAN
D
RQ
H
R
L
RE
V
M
F
Y
L
-
--
-N
LS
EQEK
DA
F
C
E
R
F
G
V
RLL
T
S
YGMTE
TIV
-
G
I
IG
---
-
D
R
P
GD
K
RRWP
S
I
GR
A
G
F
CY
-
---
E
AE
I
R
DD
HNR
PLP
A
GE
I
GE
ICI
KGVP
G
K
TI
F
K
E
YF
LN
P
K
A
TA
K
V
L
E
A
D
GW
L
H
T
GD
T
GYC
DEEG
FF
YFV
D
R
R
CN
M
I
K
RGGEN
V
S
CV
E
L
ENI
IA
T
HPKI
Q
D
I
V
VV
G
I
K
D
S
IR
D
E
A
IK
A
F
VVL
N
E
G
-
ET
LS
E
EE
F
F
RF
-C
EQ
N
M
AKFK
V
P
SY
L
E
IR
K
D
LPR
N
C
SGKI
I
R
K
N
L
fig|656408.3.peg.4987
Escherichia coli H591 (12-516/517)
M
W
D
D
--
LAD
VY
G
HK
TA
L
I
CE
S
S
GG
VV
N
--
-
-R
YSY
L
ELNQ
EI
N
R
T
AN
LFYTL
GI
R
K
GD
KV
A
L
H
L
D
N
CP
EF
IFC
W
F
G
L
A
KIGA
IM
VP
I
N
A
R
LL
R
E
E
S
A
W
I
L
QNS
QA
CLLVTS
A
QFYP
MYQ
QI
Q
-
--
--
---
Q
ED
A
T
QL
RH
I
CLT
D
VALP
A
D
DG
V
S
S
FT
QL
K
N
-
----------
Q
Q
PAT
LC
Y
A
P
P
LST
D
D
T
A
EI
LFTSGTT
S
R
PKGV
VI
TH
Y
N
LRF
A
G
Y
Y
S
AWQ
C
A
L
R
D
D
DVYL
TVM
PA
F
H
IDCQCT
A
AM
A
A
-----
F
S
AGAT
F
VL
VEKY
SA
R
A
F
WG
Q
A
Q
K
Y
R
A
T
I
T
ECI
P
M
M
IR
T
L
M
V
Q
P
P
SAN
D
RQ
H
R
L
RE
V
M
F
Y
L
-
--
-N
LS
EQEK
DA
F
C
E
R
F
G
V
RLL
T
S
YGMTE
TIV
-
G
I
IG
---
-
D
R
P
GD
K
RRWP
S
I
GR
A
G
F
CY
-
---
E
AE
I
R
DD
HNR
PLP
A
GE
I
GE
ICI
KGVP
G
K
TI
F
K
E
YF
LN
P
K
A
TA
K
V
L
E
A
D
GW
L
H
T
GD
T
GYC
DEEG
FF
YFV
D
R
R
CN
M
I
K
RGGEN
V
S
CV
E
L
ENI
IA
T
HPKI
Q
D
I
V
VV
G
I
K
D
S
IR
D
E
A
IK
A
F
VVL
N
E
G
-
ET
LS
E
EE
F
F
RF
-C
EQ
N
M
AKFK
V
P
SY
L
E
IR
K
D
LPR
N
C
SGKI
I
R
K
N
L
fig|679206.4.peg.1738
Escherichia coli MS 119-7 (12-516/517)
M
W
D
D
--
LAD
VY
G
HK
TA
L
I
CE
S
S
GG
VV
N
--
-
-R
YSY
L
ELNQ
EI
N
R
T
AN
LFYTL
GI
R
K
GD
KV
A
L
H
L
D
N
CP
EF
IFC
W
F
G
L
A
KIGA
IM
VP
I
N
A
R
LL
R
E
E
S
A
W
I
L
QNS
QA
CLLVTS
A
QFYP
MYQ
QI
Q
-
--
--
---
Q
ED
A
T
QL
RH
I
CLT
D
VALP
A
D
DG
V
S
S
FT
QL
K
N
-
----------
Q
Q
PAT
LC
Y
A
P
P
LST
D
D
T
A
EI
LFTSGTT
S
R
PKGV
VI
TH
Y
N
LRF
A
G
Y
Y
S
AWQ
C
A
L
R
D
D
DVYL
TVM
PA
F
H
IDCQCT
A
AM
A
A
-----
F
S
AGAT
F
VL
VEKY
SA
R
A
F
WG
Q
A
Q
K
Y
R
A
T
I
T
ECI
P
M
M
IR
T
L
M
V
Q
P
P
SAN
D
RQ
H
R
L
RE
V
M
F
Y
L
-
--
-N
LS
EQEK
DA
F
C
E
R
F
G
V
RLL
T
S
YGMTE
TIV
-
G
I
IG
---
-
D
R
P
GD
K
RRWP
S
I
GR
A
G
F
CY
-
---
E
AE
I
R
DD
HNR
PLP
A
GE
I
GE
ICI
KGVP
G
K
TI
F
K
E
YF
LN
P
K
A
TA
K
V
L
E
A
D
GW
L
H
T
GD
T
GYC
DEEG
FF
YFV
D
R
R
CN
M
I
K
RGGEN
V
S
CV
E
L
ENI
IA
T
HPKI
Q
D
I
V
VV
G
I
K
D
S
IR
D
E
A
IK
A
F
VVL
N
E
G
-
ET
LS
E
EE
F
F
RF
-C
EQ
N
M
AKFK
V
P
SY
L
E
IR
K
D
LPR
N
C
SGKI
I
R
K
N
L
fig|340186.3.peg.4202
Escherichia coli E110019 (17-521/522)
M
W
D
D
--
LAD
VY
G
HK
TA
L
I
CE
S
S
GG
VV
N
--
-
-R
YSY
L
ELNQ
EI
N
R
T
AN
LFYTL
GI
R
K
GD
KV
A
L
H
L
D
N
CP
EF
IFS
W
F
G
L
A
KIGA
IM
VP
I
N
A
R
LL
R
E
E
S
A
W
I
L
QNS
QA
CLLVTS
A
QFYP
MYQ
QI
Q
-
--
--
---
Q
ED
A
T
QL
RH
I
CLT
D
VALP
A
D
DG
V
S
S
FT
QL
K
N
-
----------
Q
Q
PAT
LC
Y
A
P
P
LLT
D
D
T
A
EI
LFTSGTT
S
R
PKGV
VI
TH
Y
N
LRF
A
G
Y
Y
S
AWQ
C
A
L
R
D
D
DVYL
TVM
PA
F
H
IDCQCT
A
AM
A
A
-----
F
S
AGAT
F
VL
VEKY
SA
R
A
F
WG
Q
V
Q
K
Y
R
A
T
I
T
ECI
P
M
M
IR
T
L
M
V
Q
P
P
SAN
D
RQ
H
R
L
RE
V
M
F
Y
L
-
--
-N
LS
EQEK
DA
F
C
E
R
F
G
V
RLL
T
S
YGMTE
TIV
-
G
I
IG
---
-
D
R
P
GD
K
RRWP
S
I
GR
A
G
F
CY
-
---
E
AE
I
R
DD
HNR
PLP
A
GE
I
GE
ICI
KGVP
G
K
TI
F
K
E
YF
LN
P
K
A
TA
K
V
L
E
A
D
GW
L
H
T
GD
T
GYC
DEEG
FF
YFV
D
R
R
CN
M
I
K
RGGEN
V
S
CV
E
L
ENI
IA
T
HPKI
Q
D
I
V
VV
G
I
K
D
S
IR
D
E
A
IK
A
F
VVL
N
E
G
-
ET
LS
E
EE
F
F
RF
-C
EQ
N
M
AKFK
V
P
SY
L
E
IR
K
D
LPR
N
C
SGKI
I
R
K
N
L
fig|340186.5.peg.4417
Escherichia coli E110019 (12-516/517)
M
W
D
D
--
LAD
VY
G
HK
TA
L
I
CE
S
S
GG
VV
N
--
-
-R
YSY
L
ELNQ
EI
N
R
T
AN
LFYTL
GI
R
K
GD
KV
A
L
H
L
D
N
CP
EF
IFS
W
F
G
L
A
KIGA
IM
VP
I
N
A
R
LL
R
E
E
S
A
W
I
L
QNS
QA
CLLVTS
A
QFYP
MYQ
QI
Q
-
--
--
---
Q
ED
A
T
QL
RH
I
CLT
D
VALP
A
D
DG
V
S
S
FT
QL
K
N
-
----------
Q
Q
PAT
LC
Y
A
P
P
LLT
D
D
T
A
EI
LFTSGTT
S
R
PKGV
VI
TH
Y
N
LRF
A
G
Y
Y
S
AWQ
C
A
L
R
D
D
DVYL
TVM
PA
F
H
IDCQCT
A
AM
A
A
-----
F
S
AGAT
F
VL
VEKY
SA
R
A
F
WG
Q
V
Q
K
Y
R
A
T
I
T
ECI
P
M
M
IR
T
L
M
V
Q
P
P
SAN
D
RQ
H
R
L
RE
V
M
F
Y
L
-
--
-N
LS
EQEK
DA
F
C
E
R
F
G
V
RLL
T
S
YGMTE
TIV
-
G
I
IG
---
-
D
R
P
GD
K
RRWP
S
I
GR
A
G
F
CY
-
---
E
AE
I
R
DD
HNR
PLP
A
GE
I
GE
ICI
KGVP
G
K
TI
F
K
E
YF
LN
P
K
A
TA
K
V
L
E
A
D
GW
L
H
T
GD
T
GYC
DEEG
FF
YFV
D
R
R
CN
M
I
K
RGGEN
V
S
CV
E
L
ENI
IA
T
HPKI
Q
D
I
V
VV
G
I
K
D
S
IR
D
E
A
IK
A
F
VVL
N
E
G
-
ET
LS
E
EE
F
F
RF
-C
EQ
N
M
AKFK
V
P
SY
L
E
IR
K
D
LPR
N
C
SGKI
I
R
K
N
L
fig|566546.3.peg.1697
Escherichia coli W (12-516/517)
M
W
D
D
--
LAD
VY
G
HK
TA
L
I
CE
S
S
GG
VV
N
--
-
-R
YSY
L
ELNQ
EI
N
R
T
AN
LFYTL
GI
R
K
GD
KV
A
L
H
L
D
N
CP
EF
IFC
W
F
G
L
A
KIGA
IM
VP
I
N
A
R
LL
R
E
E
S
A
W
I
L
QNS
QA
CLLVTS
A
QFYP
MYQ
QI
Q
-
--
--
---
Q
ED
A
T
QL
RH
I
CLT
D
VALP
A
D
DG
V
S
S
FT
QL
K
N
-
----------
Q
Q
PAT
LC
Y
A
P
P
LST
D
D
T
A
EI
LFTSGTT
S
R
PKGV
VI
TH
Y
N
LRF
A
G
Y
Y
S
AWQ
C
A
L
R
D
D
DVYL
TVM
PA
F
H
IDCQCT
A
AM
A
A
-----
F
S
AGAT
F
VL
VEKY
SA
R
A
F
WG
Q
V
Q
K
Y
R
A
T
I
T
ECI
P
M
M
IR
T
L
M
V
Q
P
P
SAN
D
RQ
H
R
L
RE
V
M
F
Y
L
-
--
-N
LS
EQEK
DA
F
C
E
R
F
G
V
RLL
T
S
YGMTE
TIV
-
G
I
IG
---
-
D
R
P
GD
K
RRWP
S
I
GR
A
G
F
CY
-
---
E
AE
I
R
DD
HNR
PLP
A
GE
I
GE
ICI
KGVP
G
K
TI
F
K
E
YF
LN
P
K
A
TA
K
V
L
E
A
D
GW
L
H
T
GD
T
GYC
DEEG
FF
YFV
D
R
R
CN
M
I
K
RGGEN
V
S
CV
E
L
ENI
IA
T
HPKI
Q
D
I
V
VV
G
I
K
D
S
IR
D
E
A
IK
A
F
VV
VN
E
G
-
ET
LS
E
EE
F
F
RF
-C
EQ
N
M
AKFK
V
P
SY
L
E
IR
K
D
LPR
N
C
SGKI
I
R
K
N
L
fig|550672.3.peg.4310
Escherichia coli B088 (17-521/522)
M
W
D
D
--
LAD
VY
G
HK
TA
L
I
CE
S
S
GG
VV
N
--
-
-R
YSY
L
ELNQ
EI
N
R
T
AN
LFYTL
GI
R
K
GD
KV
A
L
H
L
D
N
CP
EF
IFC
W
F
G
L
A
KIGA
IM
VP
I
N
A
R
LL
R
E
E
S
A
W
I
L
QNS
QA
CLLVTS
A
QFYP
MYQ
QI
Q
-
--
--
---
Q
ED
A
T
QL
RH
I
CLT
D
VALP
A
D
DG
V
S
S
FT
QL
K
N
-
----------
Q
Q
PAT
LC
Y
A
P
P
LST
D
D
T
A
EI
LFTSGTT
S
R
PKGV
VI
TH
Y
N
LRF
A
G
Y
Y
S
AWQ
C
A
L
R
D
D
DVYL
TVM
PA
F
H
IDCQCT
A
AM
A
A
-----
F
S
AGAT
F
VL
VEKY
SA
R
A
F
WG
Q
V
Q
K
Y
R
A
T
I
T
ECI
P
M
M
IR
T
L
M
V
Q
P
P
SAN
D
RQ
H
R
L
RE
V
M
F
Y
L
-
--
-N
LS
EQEK
DA
F
C
E
R
F
G
V
RLL
T
S
YGMTE
TIV
-
G
I
IG
---
-
D
R
P
GD
K
RRWP
S
I
GR
A
G
F
CY
-
---
E
AE
I
R
DD
HNR
PLP
A
GE
I
GE
ICI
KGVP
G
K
TI
F
K
E
YF
LN
P
K
A
TA
K
V
L
E
A
D
GW
L
H
T
GD
T
GYC
DEEG
FF
YFV
D
R
R
CN
M
I
K
RGGEN
V
S
CV
E
L
ENI
IA
T
HPKI
Q
D
I
V
VV
G
I
K
D
S
IR
D
E
A
IK
A
F
VV
VN
E
G
-
ET
LS
E
EE
F
F
RF
-C
EQ
N
M
AKFK
V
P
SY
L
E
IR
K
D
LPR
N
C
SGKI
I
R
K
N
L
fig|585034.4.peg.38
Escherichia coli IAI1 (17-521/522)
M
W
D
D
--
LAD
VY
G
HK
TA
L
I
CE
S
S
GG
VV
N
--
-
-R
YSY
L
ELNQ
EI
N
R
T
AN
LFYTL
GI
R
K
GD
KV
A
L
H
L
D
N
CP
EF
IFC
W
F
G
L
A
KIGA
IM
VP
I
N
A
R
LL
R
E
E
S
A
W
I
L
QNS
QA
CLLVTS
A
QFYP
MYQ
QI
Q
-
--
--
---
Q
ED
A
T
QL
RH
I
CLT
D
VALP
A
D
DG
V
S
S
FT
QL
K
N
-
----------
Q
Q
PAT
LC
Y
A
P
P
LST
D
D
T
A
EI
LFTSGTT
S
R
PKGV
VI
TH
Y
N
LRF
A
G
Y
Y
S
AWQ
C
A
L
R
D
D
DVYL
TVM
PA
F
H
IDCQCT
A
AM
A
A
-----
F
S
AGAT
F
VL
VEKY
SA
R
A
F
WG
Q
V
Q
K
Y
R
A
T
I
T
ECI
P
M
M
IR
T
L
M
V
Q
P
P
SAN
D
RQ
H
R
L
RE
V
M
F
Y
L
-
--
-N
LS
EQEK
DA
F
C
E
R
F
G
V
RLL
T
S
YGMTE
TIV
-
G
I
IG
---
-
D
R
P
GD
K
RRWP
S
I
GR
A
G
F
CY
-
---
E
AE
I
R
DD
HNR
PLP
A
GE
I
GE
ICI
KGVP
G
K
TI
F
K
E
YF
LN
P
K
A
TA
K
V
L
E
A
D
GW
L
H
T
GD
T
GYC
DEEG
FF
YFV
D
R
R
CN
M
I
K
RGGEN
V
S
CV
E
L
ENI
IA
T
HPKI
Q
D
I
V
VV
G
I
K
D
S
IR
D
E
A
IK
A
F
VV
VN
E
G
-
ET
LS
E
EE
F
F
RF
-C
EQ
N
M
AKFK
V
P
SY
L
E
IR
K
D
LPR
N
C
SGKI
I
R
K
N
L
fig|585034.5.peg.38
Escherichia coli IAI1 (17-521/522)
M
W
D
D
--
LAD
VY
G
HK
TA
L
I
CE
S
S
GG
VV
N
--
-
-R
YSY
L
ELNQ
EI
N
R
T
AN
LFYTL
GI
R
K
GD
KV
A
L
H
L
D
N
CP
EF
IFC
W
F
G
L
A
KIGA
IM
VP
I
N
A
R
LL
R
E
E
S
A
W
I
L
QNS
QA
CLLVTS
A
QFYP
MYQ
QI
Q
-
--
--
---
Q
ED
A
T
QL
RH
I
CLT
D
VALP
A
D
DG
V
S
S
FT
QL
K
N
-
----------
Q
Q
PAT
LC
Y
A
P
P
LST
D
D
T
A
EI
LFTSGTT
S
R
PKGV
VI
TH
Y
N
LRF
A
G
Y
Y
S
AWQ
C
A
L
R
D
D
DVYL
TVM
PA
F
H
IDCQCT
A
AM
A
A
-----
F
S
AGAT
F
VL
VEKY
SA
R
A
F
WG
Q
V
Q
K
Y
R
A
T
I
T
ECI
P
M
M
IR
T
L
M
V
Q
P
P
SAN
D
RQ
H
R
L
RE
V
M
F
Y
L
-
--
-N
LS
EQEK
DA
F
C
E
R
F
G
V
RLL
T
S
YGMTE
TIV
-
G
I
IG
---
-
D
R
P
GD
K
RRWP
S
I
GR
A
G
F
CY
-
---
E
AE
I
R
DD
HNR
PLP
A
GE
I
GE
ICI
KGVP
G
K
TI
F
K
E
YF
LN
P
K
A
TA
K
V
L
E
A
D
GW
L
H
T
GD
T
GYC
DEEG
FF
YFV
D
R
R
CN
M
I
K
RGGEN
V
S
CV
E
L
ENI
IA
T
HPKI
Q
D
I
V
VV
G
I
K
D
S
IR
D
E
A
IK
A
F
VV
VN
E
G
-
ET
LS
E
EE
F
F
RF
-C
EQ
N
M
AKFK
V
P
SY
L
E
IR
K
D
LPR
N
C
SGKI
I
R
K
N
L
fig|595495.4.peg.1690
Escherichia coli KO11 (17-521/522)
M
W
D
D
--
LAD
VY
G
HK
TA
L
I
CE
S
S
GG
VV
N
--
-
-R
YSY
L
ELNQ
EI
N
R
T
AN
LFYTL
GI
R
K
GD
KV
A
L
H
L
D
N
CP
EF
IFC
W
F
G
L
A
KIGA
IM
VP
I
N
A
R
LL
R
E
E
S
A
W
I
L
QNS
QA
CLLVTS
A
QFYP
MYQ
QI
Q
-
--
--
---
Q
ED
A
T
QL
RH
I
CLT
D
VALP
A
D
DG
V
S
S
FT
QL
K
N
-
----------
Q
Q
PAT
LC
Y
A
P
P
LST
D
D
T
A
EI
LFTSGTT
S
R
PKGV
VI
TH
Y
N
LRF
A
G
Y
Y
S
AWQ
C
A
L
R
D
D
DVYL
TVM
PA
F
H
IDCQCT
A
AM
A
A
-----
F
S
AGAT
F
VL
VEKY
SA
R
A
F
WG
Q
V
Q
K
Y
R
A
T
I
T
ECI
P
M
M
IR
T
L
M
V
Q
P
P
SAN
D
RQ
H
R
L
RE
V
M
F
Y
L
-
--
-N
LS
EQEK
DA
F
C
E
R
F
G
V
RLL
T
S
YGMTE
TIV
-
G
I
IG
---
-
D
R
P
GD
K
RRWP
S
I
GR
A
G
F
CY
-
---
E
AE
I
R
DD
HNR
PLP
A
GE
I
GE
ICI
KGVP
G
K
TI
F
K
E
YF
LN
P
K
A
TA
K
V
L
E
A
D
GW
L
H
T
GD
T
GYC
DEEG
FF
YFV
D
R
R
CN
M
I
K
RGGEN
V
S
CV
E
L
ENI
IA
T
HPKI
Q
D
I
V
VV
G
I
K
D
S
IR
D
E
A
IK
A
F
VV
VN
E
G
-
ET
LS
E
EE
F
F
RF
-C
EQ
N
M
AKFK
V
P
SY
L
E
IR
K
D
LPR
N
C
SGKI
I
R
K
N
L
fig|566546.4.peg.36
Escherichia coli W (17-521/522)
M
W
D
D
--
LAD
VY
G
HK
TA
L
I
CE
S
S
GG
VV
N
--
-
-R
YSY
L
ELNQ
EI
N
R
T
AN
LFYTL
GI
R
K
GD
KV
A
L
H
L
D
N
CP
EF
IFC
W
F
G
L
A
KIGA
IM
VP
I
N
A
R
LL
R
E
E
S
A
W
I
L
QNS
QA
CLLVTS
A
QFYP
MYQ
QI
Q
-
--
--
---
Q
ED
A
T
QL
RH
I
CLT
D
VALP
A
D
DG
V
S
S
FT
QL
K
N
-
----------
Q
Q
PAT
LC
Y
A
P
P
LST
D
D
T
A
EI
LFTSGTT
S
R
PKGV
VI
TH
Y
N
LRF
A
G
Y
Y
S
AWQ
C
A
L
R
D
D
DVYL
TVM
PA
F
H
IDCQCT
A
AM
A
A
-----
F
S
AGAT
F
VL
VEKY
SA
R
A
F
WG
Q
V
Q
K
Y
R
A
T
I
T
ECI
P
M
M
IR
T
L
M
V
Q
P
P
SAN
D
RQ
H
R
L
RE
V
M
F
Y
L
-
--
-N
LS
EQEK
DA
F
C
E
R
F
G
V
RLL
T
S
YGMTE
TIV
-
G
I
IG
---
-
D
R
P
GD
K
RRWP
S
I
GR
A
G
F
CY
-
---
E
AE
I
R
DD
HNR
PLP
A
GE
I
GE
ICI
KGVP
G
K
TI
F
K
E
YF
LN
P
K
A
TA
K
V
L
E
A
D
GW
L
H
T
GD
T
GYC
DEEG
FF
YFV
D
R
R
CN
M
I
K
RGGEN
V
S
CV
E
L
ENI
IA
T
HPKI
Q
D
I
V
VV
G
I
K
D
S
IR
D
E
A
IK
A
F
VV
VN
E
G
-
ET
LS
E
EE
F
F
RF
-C
EQ
N
M
AKFK
V
P
SY
L
E
IR
K
D
LPR
N
C
SGKI
I
R
K
N
L
fig|656393.3.peg.647
Escherichia coli H299 (12-516/517)
M
W
D
D
--
LAD
VY
G
HK
TA
L
I
CE
S
S
S
G
VV
N
--
-
-R
YSY
L
ELNQ
EI
N
R
T
AN
LFYTL
GI
R
K
GD
KV
A
L
H
L
D
N
CP
EF
IFC
W
F
G
L
A
KIGA
IM
VP
I
N
A
R
LL
R
E
E
S
T
W
I
L
QNS
QA
CLLVTS
A
QFYP
MYQ
QI
Q
-
--
--
---
Q
ED
A
S
QL
RH
I
CLT
D
MALP
A
D
DG
V
S
S
FT
QL
K
N
-
----------
Q
Q
PAT
LC
Y
A
P
P
LST
D
D
T
A
EI
LFTSGTT
S
R
PKGV
VI
TH
Y
N
LRF
A
G
Y
Y
S
AWQ
C
A
L
R
D
D
DVYL
TVM
PA
F
H
IDCQCT
A
AM
A
A
-----
F
S
AGAT
F
VL
VEKY
SA
R
A
F
WG
Q
V
Q
N
Y
R
A
T
I
T
ECI
P
M
M
IR
T
L
M
V
Q
P
L
SAN
D
RQ
H
C
L
RE
V
M
F
Y
L
-
--
-N
LS
EQEK
DA
F
C
E
R
F
S
V
RLL
T
S
YGMTE
TIV
-
G
I
IG
---
-
D
R
P
GD
K
RRWP
S
I
GR
A
G
F
CY
-
---
E
AE
I
R
DD
HNR
PLP
A
GE
L
GE
ICI
KGVP
G
K
TI
F
K
E
YF
LN
P
K
A
TA
K
V
L
E
A
D
GW
L
H
T
GD
T
GYR
DEEG
FF
YFV
D
R
R
CN
M
I
K
RGGEN
V
S
CV
E
L
ENI
IA
T
HPKI
Q
D
I
V
VV
G
I
K
D
S
IR
D
E
A
IK
A
F
VVL
N
E
G
-
ET
LS
E
EE
F
F
C
F
-C
EQ
N
M
AKFK
V
P
SY
L
E
IR
K
D
LPR
N
C
SGKI
I
R
K
N
L
fig|83334.1.peg.128
Escherichia coli O157:H7 (17-521/522)
M
W
D
D
--
LAD
VY
G
HK
TA
L
I
CE
S
S
GG
VV
N
--
-
-R
YSY
L
ELNQ
EI
N
R
T
AN
LFYTL
GI
R
K
GD
KV
A
L
H
L
D
N
CP
EF
IFC
W
F
G
L
A
KIGA
IM
VP
I
N
A
R
LL
R
E
E
S
A
W
I
L
QNS
QA
CLLVTS
A
QFYP
MYQ
QI
Q
-
--
--
---
Q
ED
A
T
QL
RH
I
CLT
D
VALP
A
D
DG
V
S
S
FT
QL
K
N
-
----------
Q
Q
PAT
LC
Y
A
P
P
LST
D
D
T
A
EI
LFTSGTT
S
R
PKGV
VI
TH
Y
N
LRF
A
G
Y
Y
S
AWQ
C
A
L
R
D
D
DVYL
TVM
PA
F
H
IDCQCT
A
AM
A
A
-----
F
S
AGAT
F
VL
VEKY
SA
R
A
F
WG
Q
V
Q
K
Y
R
A
T
I
T
ECI
P
M
M
IR
T
L
M
V
Q
P
P
SAN
D
RQ
H
R
L
RE
V
M
F
Y
L
-
--
-N
LS
EQEK
D
T
F
C
E
R
F
G
V
RLL
T
S
YGMTE
TIV
-
G
I
IG
---
-
D
R
P
GD
K
RRWP
S
I
GR
A
G
F
CY
-
---
D
AE
I
R
DD
HNR
PLP
A
GE
I
GE
ICI
KGVP
G
K
TI
F
K
E
YF
LN
P
K
A
TA
K
V
L
E
A
D
GW
L
H
T
GD
T
GYR
DEEG
FF
YFI
D
R
R
CN
M
I
K
RGGEN
V
S
CV
E
L
ENI
IA
T
HPKI
Q
D
I
V
VV
G
I
K
D
S
IR
D
E
A
IK
A
F
VVL
N
E
G
-
ET
LS
E
EE
F
F
RF
-C
EQ
N
M
AKFK
V
P
SY
L
E
IR
K
D
LPR
N
C
SGKI
I
R
K
N
L
fig|155864.1.peg.40
Escherichia coli O157:H7 EDL933 (17-521/522)
M
W
D
D
--
LAD
VY
G
HK
TA
L
I
CE
S
S
GG
VV
N
--
-
-R
YSY
L
ELNQ
EI
N
R
T
AN
LFYTL
GI
R
K
GD
KV
A
L
H
L
D
N
CP
EF
IFC
W
F
G
L
A
KIGA
IM
VP
I
N
A
R
LL
R
E
E
S
A
W
I
L
QNS
QA
CLLVTS
A
QFYP
MYQ
QI
Q
-
--
--
---
Q
ED
A
T
QL
RH
I
CLT
D
VALP
A
D
DG
V
S
S
FT
QL
K
N
-
----------
Q
Q
PAT
LC
Y
A
P
P
LST
D
D
T
A
EI
LFTSGTT
S
R
PKGV
VI
TH
Y
N
LRF
A
G
Y
Y
S
AWQ
C
A
L
R
D
D
DVYL
TVM
PA
F
H
IDCQCT
A
AM
A
A
-----
F
S
AGAT
F
VL
VEKY
SA
R
A
F
WG
Q
V
Q
K
Y
R
A
T
I
T
ECI
P
M
M
IR
T
L
M
V
Q
P
P
SAN
D
RQ
H
R
L
RE
V
M
F
Y
L
-
--
-N
LS
EQEK
D
T
F
C
E
R
F
G
V
RLL
T
S
YGMTE
TIV
-
G
I
IG
---
-
D
R
P
GD
K
RRWP
S
I
GR
A
G
F
CY
-
---
D
AE
I
R
DD
HNR
PLP
A
GE
I
GE
ICI
KGVP
G
K
TI
F
K
E
YF
LN
P
K
A
TA
K
V
L
E
A
D
GW
L
H
T
GD
T
GYR
DEEG
FF
YFI
D
R
R
CN
M
I
K
RGGEN
V
S
CV
E
L
ENI
IA
T
HPKI
Q
D
I
V
VV
G
I
K
D
S
IR
D
E
A
IK
A
F
VVL
N
E
G
-
ET
LS
E
EE
F
F
RF
-C
EQ
N
M
AKFK
V
P
SY
L
E
IR
K
D
LPR
N
C
SGKI
I
R
K
N
L
fig|478005.5.peg.915
Escherichia coli O157:H7 str. EC4486 (17-521/522)
M
W
D
D
--
LAD
VY
G
HK
TA
L
I
CE
S
S
GG
VV
N
--
-
-R
YSY
L
ELNQ
EI
N
R
T
AN
LFYTL
GI
R
K
GD
KV
A
L
H
L
D
N
CP
EF
IFC
W
F
G
L
A
KIGA
IM
VP
I
N
A
R
LL
R
E
E
S
A
W
I
L
QNS
QA
CLLVTS
A
QFYP
MYQ
QI
Q
-
--
--
---
Q
ED
A
T
QL
RH
I
CLT
D
VALP
A
D
DG
V
S
S
FT
QL
K
N
-
----------
Q
Q
PAT
LC
Y
A
P
P
LST
D
D
T
A
EI
LFTSGTT
S
R
PKGV
VI
TH
Y
N
LRF
A
G
Y
Y
S
AWQ
C
A
L
R
D
D
DVYL
TVM
PA
F
H
IDCQCT
A
AM
A
A
-----
F
S
AGAT
F
VL
VEKY
SA
R
A
F
WG
Q
V
Q
K
Y
R
A
T
I
T
ECI
P
M
M
IR
T
L
M
V
Q
P
P
SAN
D
RQ
H
R
L
RE
V
M
F
Y
L
-
--
-N
LS
EQEK
D
T
F
C
E
R
F
G
V
RLL
T
S
YGMTE
TIV
-
G
I
IG
---
-
D
R
P
GD
K
RRWP
S
I
GR
A
G
F
CY
-
---
D
AE
I
R
DD
HNR
PLP
A
GE
I
GE
ICI
KGVP
G
K
TI
F
K
E
YF
LN
P
K
A
TA
K
V
L
E
A
D
GW
L
H
T
GD
T
GYR
DEEG
FF
YFI
D
R
R
CN
M
I
K
RGGEN
V
S
CV
E
L
ENI
IA
T
HPKI
Q
D
I
V
VV
G
I
K
D
S
IR
D
E
A
IK
A
F
VVL
N
E
G
-
ET
LS
E
EE
F
F
RF
-C
EQ
N
M
AKFK
V
P
SY
L
E
IR
K
D
LPR
N
C
SGKI
I
R
K
N
L
fig|562.371.peg.3970
Escherichia coli 1044A (12-516/517)
M
W
D
D
--
LAD
VY
G
HK
TA
L
I
CE
S
S
GG
VV
N
--
-
-R
YSY
L
ELNQ
EI
N
R
T
AN
LFYTL
GI
R
K
GD
KV
A
L
H
L
D
N
CP
EF
IFC
W
F
G
L
A
KIGA
IM
VP
I
N
A
R
LL
R
E
E
S
A
W
I
L
QNS
QA
CLLVTS
A
QFYP
MYQ
QI
Q
-
--
--
---
Q
ED
A
T
QL
RH
I
CLT
D
VALP
A
D
DG
V
S
S
FT
QL
K
N
-
----------
Q
Q
PAT
LC
Y
A
P
P
LST
D
D
T
A
EI
LFTSGTT
S
R
PKGV
VI
TH
Y
N
LRF
A
G
Y
Y
S
AWQ
C
A
L
R
D
D
DVYL
TVM
PA
F
H
IDCQCT
A
AM
A
A
-----
F
S
AGAT
F
VL
VEKY
SA
R
A
F
WG
Q
V
Q
K
Y
R
A
T
I
T
ECI
P
M
M
IR
T
L
M
V
Q
P
P
SAN
D
RQ
H
R
L
RE
V
M
F
Y
L
-
--
-N
LS
EQEK
D
T
F
C
E
R
F
G
V
RLL
T
S
YGMTE
TIV
-
G
I
IG
---
-
D
R
P
GD
K
RRWP
S
I
GR
A
G
F
CY
-
---
D
AE
I
R
DD
HNR
PLP
A
GE
I
GE
ICI
KGVP
G
K
TI
F
K
E
YF
LN
P
K
A
TA
K
V
L
E
A
D
GW
L
H
T
GD
T
GYR
DEEG
FF
YFI
D
R
R
CN
M
I
K
RGGEN
V
S
CV
E
L
ENI
IA
T
HPKI
Q
D
I
V
VV
G
I
K
D
S
IR
D
E
A
IK
A
F
VVL
N
E
G
-
ET
LS
E
EE
F
F
RF
-C
EQ
N
M
AKFK
V
P
SY
L
E
IR
K
D
LPR
N
C
SGKI
I
R
K
N
L
fig|562.373.peg.2235
Escherichia coli 1125A (12-516/517)
M
W
D
D
--
LAD
VY
G
HK
TA
L
I
CE
S
S
GG
VV
N
--
-
-R
YSY
L
ELNQ
EI
N
R
T
AN
LFYTL
GI
R
K
GD
KV
A
L
H
L
D
N
CP
EF
IFC
W
F
G
L
A
KIGA
IM
VP
I
N
A
R
LL
R
E
E
S
A
W
I
L
QNS
QA
CLLVTS
A
QFYP
MYQ
QI
Q
-
--
--
---
Q
ED
A
T
QL
RH
I
CLT
D
VALP
A
D
DG
V
S
S
FT
QL
K
N
-
----------
Q
Q
PAT
LC
Y
A
P
P
LST
D
D
T
A
EI
LFTSGTT
S
R
PKGV
VI
TH
Y
N
LRF
A
G
Y
Y
S
AWQ
C
A
L
R
D
D
DVYL
TVM
PA
F
H
IDCQCT
A
AM
A
A
-----
F
S
AGAT
F
VL
VEKY
SA
R
A
F
WG
Q
V
Q
K
Y
R
A
T
I
T
ECI
P
M
M
IR
T
L
M
V
Q
P
P
SAN
D
RQ
H
R
L
RE
V
M
F
Y
L
-
--
-N
LS
EQEK
D
T
F
C
E
R
F
G
V
RLL
T
S
YGMTE
TIV
-
G
I
IG
---
-
D
R
P
GD
K
RRWP
S
I
GR
A
G
F
CY
-
---
D
AE
I
R
DD
HNR
PLP
A
GE
I
GE
ICI
KGVP
G
K
TI
F
K
E
YF
LN
P
K
A
TA
K
V
L
E
A
D
GW
L
H
T
GD
T
GYR
DEEG
FF
YFI
D
R
R
CN
M
I
K
RGGEN
V
S
CV
E
L
ENI
IA
T
HPKI
Q
D
I
V
VV
G
I
K
D
S
IR
D
E
A
IK
A
F
VVL
N
E
G
-
ET
LS
E
EE
F
F
RF
-C
EQ
N
M
AKFK
V
P
SY
L
E
IR
K
D
LPR
N
C
SGKI
I
R
K
N
L
fig|562.372.peg.3086
Escherichia coli 1212A (12-516/517)
M
W
D
D
--
LAD
VY
G
HK
TA
L
I
CE
S
S
GG
VV
N
--
-
-R
YSY
L
ELNQ
EI
N
R
T
AN
LFYTL
GI
R
K
GD
KV
A
L
H
L
D
N
CP
EF
IFC
W
F
G
L
A
KIGA
IM
VP
I
N
A
R
LL
R
E
E
S
A
W
I
L
QNS
QA
CLLVTS
A
QFYP
MYQ
QI
Q
-
--
--
---
Q
ED
A
T
QL
RH
I
CLT
D
VALP
A
D
DG
V
S
S
FT
QL
K
N
-
----------
Q
Q
PAT
LC
Y
A
P
P
LST
D
D
T
A
EI
LFTSGTT
S
R
PKGV
VI
TH
Y
N
LRF
A
G
Y
Y
S
AWQ
C
A
L
R
D
D
DVYL
TVM
PA
F
H
IDCQCT
A
AM
A
A
-----
F
S
AGAT
F
VL
VEKY
SA
R
A
F
WG
Q
V
Q
K
Y
R
A
T
I
T
ECI
P
M
M
IR
T
L
M
V
Q
P
P
SAN
D
RQ
H
R
L
RE
V
M
F
Y
L
-
--
-N
LS
EQEK
D
T
F
C
E
R
F
G
V
RLL
T
S
YGMTE
TIV
-
G
I
IG
---
-
D
R
P
GD
K
RRWP
S
I
GR
A
G
F
CY
-
---
D
AE
I
R
DD
HNR
PLP
A
GE
I
GE
ICI
KGVP
G
K
TI
F
K
E
YF
LN
P
K
A
TA
K
V
L
E
A
D
GW
L
H
T
GD
T
GYR
DEEG
FF
YFI
D
R
R
CN
M
I
K
RGGEN
V
S
CV
E
L
ENI
IA
T
HPKI
Q
D
I
V
VV
G
I
K
D
S
IR
D
E
A
IK
A
F
VVL
N
E
G
-
ET
LS
E
EE
F
F
RF
-C
EQ
N
M
AKFK
V
P
SY
L
E
IR
K
D
LPR
N
C
SGKI
I
R
K
N
L
fig|562.374.peg.2858
Escherichia coli 536A (12-516/517)
M
W
D
D
--
LAD
VY
G
HK
TA
L
I
CE
S
S
GG
VV
N
--
-
-R
YSY
L
ELNQ
EI
N
R
T
AN
LFYTL
GI
R
K
GD
KV
A
L
H
L
D
N
CP
EF
IFC
W
F
G
L
A
KIGA
IM
VP
I
N
A
R
LL
R
E
E
S
A
W
I
L
QNS
QA
CLLVTS
A
QFYP
MYQ
QI
Q
-
--
--
---
Q
ED
A
T
QL
RH
I
CLT
D
VALP
A
D
DG
V
S
S
FT
QL
K
N
-
----------
Q
Q
PAT
LC
Y
A
P
P
LST
D
D
T
A
EI
LFTSGTT
S
R
PKGV
VI
TH
Y
N
LRF
A
G
Y
Y
S
AWQ
C
A
L
R
D
D
DVYL
TVM
PA
F
H
IDCQCT
A
AM
A
A
-----
F
S
AGAT
F
VL
VEKY
SA
R
A
F
WG
Q
V
Q
K
Y
R
A
T
I
T
ECI
P
M
M
IR
T
L
M
V
Q
P
P
SAN
D
RQ
H
R
L
RE
V
M
F
Y
L
-
--
-N
LS
EQEK
D
T
F
C
E
R
F
G
V
RLL
T
S
YGMTE
TIV
-
G
I
IG
---
-
D
R
P
GD
K
RRWP
S
I
GR
A
G
F
CY
-
---
D
AE
I
R
DD
HNR
PLP
A
GE
I
GE
ICI
KGVP
G
K
TI
F
K
E
YF
LN
P
K
A
TA
K
V
L
E
A
D
GW
L
H
T
GD
T
GYR
DEEG
FF
YFI
D
R
R
CN
M
I
K
RGGEN
V
S
CV
E
L
ENI
IA
T
HPKI
Q
D
I
V
VV
G
I
K
D
S
IR
D
E
A
IK
A
F
VVL
N
E
G
-
ET
LS
E
EE
F
F
RF
-C
EQ
N
M
AKFK
V
P
SY
L
E
IR
K
D
LPR
N
C
SGKI
I
R
K
N
L
fig|155864.8.peg.38
Escherichia coli O157:H7 EDL933 (12-516/517)
M
W
D
D
--
LAD
VY
G
HK
TA
L
I
CE
S
S
GG
VV
N
--
-
-R
YSY
L
ELNQ
EI
N
R
T
AN
LFYTL
GI
R
K
GD
KV
A
L
H
L
D
N
CP
EF
IFC
W
F
G
L
A
KIGA
IM
VP
I
N
A
R
LL
R
E
E
S
A
W
I
L
QNS
QA
CLLVTS
A
QFYP
MYQ
QI
Q
-
--
--
---
Q
ED
A
T
QL
RH
I
CLT
D
VALP
A
D
DG
V
S
S
FT
QL
K
N
-
----------
Q
Q
PAT
LC
Y
A
P
P
LST
D
D
T
A
EI
LFTSGTT
S
R
PKGV
VI
TH
Y
N
LRF
A
G
Y
Y
S
AWQ
C
A
L
R
D
D
DVYL
TVM
PA
F
H
IDCQCT
A
AM
A
A
-----
F
S
AGAT
F
VL
VEKY
SA
R
A
F
WG
Q
V
Q
K
Y
R
A
T
I
T
ECI
P
M
M
IR
T
L
M
V
Q
P
P
SAN
D
RQ
H
R
L
RE
V
M
F
Y
L
-
--
-N
LS
EQEK
D
T
F
C
E
R
F
G
V
RLL
T
S
YGMTE
TIV
-
G
I
IG
---
-
D
R
P
GD
K
RRWP
S
I
GR
A
G
F
CY
-
---
D
AE
I
R
DD
HNR
PLP
A
GE
I
GE
ICI
KGVP
G
K
TI
F
K
E
YF
LN
P
K
A
TA
K
V
L
E
A
D
GW
L
H
T
GD
T
GYR
DEEG
FF
YFI
D
R
R
CN
M
I
K
RGGEN
V
S
CV
E
L
ENI
IA
T
HPKI
Q
D
I
V
VV
G
I
K
D
S
IR
D
E
A
IK
A
F
VVL
N
E
G
-
ET
LS
E
EE
F
F
RF
-C
EQ
N
M
AKFK
V
P
SY
L
E
IR
K
D
LPR
N
C
SGKI
I
R
K
N
L
fig|444454.5.peg.4501
Escherichia coli O157:H7 str. EC4024 (12-516/517)
M
W
D
D
--
LAD
VY
G
HK
TA
L
I
CE
S
S
GG
VV
N
--
-
-R
YSY
L
ELNQ
EI
N
R
T
AN
LFYTL
GI
R
K
GD
KV
A
L
H
L
D
N
CP
EF
IFC
W
F
G
L
A
KIGA
IM
VP
I
N
A
R
LL
R
E
E
S
A
W
I
L
QNS
QA
CLLVTS
A
QFYP
MYQ
QI
Q
-
--
--
---
Q
ED
A
T
QL
RH
I
CLT
D
VALP
A
D
DG
V
S
S
FT
QL
K
N
-
----------
Q
Q
PAT
LC
Y
A
P
P
LST
D
D
T
A
EI
LFTSGTT
S
R
PKGV
VI
TH
Y
N
LRF
A
G
Y
Y
S
AWQ
C
A
L
R
D
D
DVYL
TVM
PA
F
H
IDCQCT
A
AM
A
A
-----
F
S
AGAT
F
VL
VEKY
SA
R
A
F
WG
Q
V
Q
K
Y
R
A
T
I
T
ECI
P
M
M
IR
T
L
M
V
Q
P
P
SAN
D
RQ
H
R
L
RE
V
M
F
Y
L
-
--
-N
LS
EQEK
D
T
F
C
E
R
F
G
V
RLL
T
S
YGMTE
TIV
-
G
I
IG
---
-
D
R
P
GD
K
RRWP
S
I
GR
A
G
F
CY
-
---
D
AE
I
R
DD
HNR
PLP
A
GE
I
GE
ICI
KGVP
G
K
TI
F
K
E
YF
LN
P
K
A
TA
K
V
L
E
A
D
GW
L
H
T
GD
T
GYR
DEEG
FF
YFI
D
R
R
CN
M
I
K
RGGEN
V
S
CV
E
L
ENI
IA
T
HPKI
Q
D
I
V
VV
G
I
K
D
S
IR
D
E
A
IK
A
F
VVL
N
E
G
-
ET
LS
E
EE
F
F
RF
-C
EQ
N
M
AKFK
V
P
SY
L
E
IR
K
D
LPR
N
C
SGKI
I
R
K
N
L
fig|444449.5.peg.3949
Escherichia coli O157:H7 str. EC4042 (12-516/517)
M
W
D
D
--
LAD
VY
G
HK
TA
L
I
CE
S
S
GG
VV
N
--
-
-R
YSY
L
ELNQ
EI
N
R
T
AN
LFYTL
GI
R
K
GD
KV
A
L
H
L
D
N
CP
EF
IFC
W
F
G
L
A
KIGA
IM
VP
I
N
A
R
LL
R
E
E
S
A
W
I
L
QNS
QA
CLLVTS
A
QFYP
MYQ
QI
Q
-
--
--
---
Q
ED
A
T
QL
RH
I
CLT
D
VALP
A
D
DG
V
S
S
FT
QL
K
N
-
----------
Q
Q
PAT
LC
Y
A
P
P
LST
D
D
T
A
EI
LFTSGTT
S
R
PKGV
VI
TH
Y
N
LRF
A
G
Y
Y
S
AWQ
C
A
L
R
D
D
DVYL
TVM
PA
F
H
IDCQCT
A
AM
A
A
-----
F
S
AGAT
F
VL
VEKY
SA
R
A
F
WG
Q
V
Q
K
Y
R
A
T
I
T
ECI
P
M
M
IR
T
L
M
V
Q
P
P
SAN
D
RQ
H
R
L
RE
V
M
F
Y
L
-
--
-N
LS
EQEK
D
T
F
C
E
R
F
G
V
RLL
T
S
YGMTE
TIV
-
G
I
IG
---
-
D
R
P
GD
K
RRWP
S
I
GR
A
G
F
CY
-
---
D
AE
I
R
DD
HNR
PLP
A
GE
I
GE
ICI
KGVP
G
K
TI
F
K
E
YF
LN
P
K
A
TA
K
V
L
E
A
D
GW
L
H
T
GD
T
GYR
DEEG
FF
YFI
D
R
R
CN
M
I
K
RGGEN
V
S
CV
E
L
ENI
IA
T
HPKI
Q
D
I
V
VV
G
I
K
D
S
IR
D
E
A
IK
A
F
VVL
N
E
G
-
ET
LS
E
EE
F
F
RF
-C
EQ
N
M
AKFK
V
P
SY
L
E
IR
K
D
LPR
N
C
SGKI
I
R
K
N
L
fig|444448.5.peg.2709
Escherichia coli O157:H7 str. EC4045 (12-516/517)
M
W
D
D
--
LAD
VY
G
HK
TA
L
I
CE
S
S
GG
VV
N
--
-
-R
YSY
L
ELNQ
EI
N
R
T
AN
LFYTL
GI
R
K
GD
KV
A
L
H
L
D
N
CP
EF
IFC
W
F
G
L
A
KIGA
IM
VP
I
N
A
R
LL
R
E
E
S
A
W
I
L
QNS
QA
CLLVTS
A
QFYP
MYQ
QI
Q
-
--
--
---
Q
ED
A
T
QL
RH
I
CLT
D
VALP
A
D
DG
V
S
S
FT
QL
K
N
-
----------
Q
Q
PAT
LC
Y
A
P
P
LST
D
D
T
A
EI
LFTSGTT
S
R
PKGV
VI
TH
Y
N
LRF
A
G
Y
Y
S
AWQ
C
A
L
R
D
D
DVYL
TVM
PA
F
H
IDCQCT
A
AM
A
A
-----
F
S
AGAT
F
VL
VEKY
SA
R
A
F
WG
Q
V
Q
K
Y
R
A
T
I
T
ECI
P
M
M
IR
T
L
M
V
Q
P
P
SAN
D
RQ
H
R
L
RE
V
M
F
Y
L
-
--
-N
LS
EQEK
D
T
F
C
E
R
F
G
V
RLL
T
S
YGMTE
TIV
-
G
I
IG
---
-
D
R
P
GD
K
RRWP
S
I
GR
A
G
F
CY
-
---
D
AE
I
R
DD
HNR
PLP
A
GE
I
GE
ICI
KGVP
G
K
TI
F
K
E
YF
LN
P
K
A
TA
K
V
L
E
A
D
GW
L
H
T
GD
T
GYR
DEEG
FF
YFI
D
R
R
CN
M
I
K
RGGEN
V
S
CV
E
L
ENI
IA
T
HPKI
Q
D
I
V
VV
G
I
K
D
S
IR
D
E
A
IK
A
F
VVL
N
E
G
-
ET
LS
E
EE
F
F
RF
-C
EQ
N
M
AKFK
V
P
SY
L
E
IR
K
D
LPR
N
C
SGKI
I
R
K
N
L
fig|444453.5.peg.3145
Escherichia coli O157:H7 str. EC4076 (12-516/517)
M
W
D
D
--
LAD
VY
G
HK
TA
L
I
CE
S
S
GG
VV
N
--
-
-R
YSY
L
ELNQ
EI
N
R
T
AN
LFYTL
GI
R
K
GD
KV
A
L
H
L
D
N
CP
EF
IFC
W
F
G
L
A
KIGA
IM
VP
I
N
A
R
LL
R
E
E
S
A
W
I
L
QNS
QA
CLLVTS
A
QFYP
MYQ
QI
Q
-
--
--
---
Q
ED
A
T
QL
RH
I
CLT
D
VALP
A
D
DG
V
S
S
FT
QL
K
N
-
----------
Q
Q
PAT
LC
Y
A
P
P
LST
D
D
T
A
EI
LFTSGTT
S
R
PKGV
VI
TH
Y
N
LRF
A
G
Y
Y
S
AWQ
C
A
L
R
D
D
DVYL
TVM
PA
F
H
IDCQCT
A
AM
A
A
-----
F
S
AGAT
F
VL
VEKY
SA
R
A
F
WG
Q
V
Q
K
Y
R
A
T
I
T
ECI
P
M
M
IR
T
L
M
V
Q
P
P
SAN
D
RQ
H
R
L
RE
V
M
F
Y
L
-
--
-N
LS
EQEK
D
T
F
C
E
R
F
G
V
RLL
T
S
YGMTE
TIV
-
G
I
IG
---
-
D
R
P
GD
K
RRWP
S
I
GR
A
G
F
CY
-
---
D
AE
I
R
DD
HNR
PLP
A
GE
I
GE
ICI
KGVP
G
K
TI
F
K
E
YF
LN
P
K
A
TA
K
V
L
E
A
D
GW
L
H
T
GD
T
GYR
DEEG
FF
YFI
D
R
R
CN
M
I
K
RGGEN
V
S
CV
E
L
ENI
IA
T
HPKI
Q
D
I
V
VV
G
I
K
D
S
IR
D
E
A
IK
A
F
VVL
N
E
G
-
ET
LS
E
EE
F
F
RF
-C
EQ
N
M
AKFK
V
P
SY
L
E
IR
K
D
LPR
N
C
SGKI
I
R
K
N
L
fig|444452.5.peg.4598
Escherichia coli O157:H7 str. EC4113 (12-516/517)
M
W
D
D
--
LAD
VY
G
HK
TA
L
I
CE
S
S
GG
VV
N
--
-
-R
YSY
L
ELNQ
EI
N
R
T
AN
LFYTL
GI
R
K
GD
KV
A
L
H
L
D
N
CP
EF
IFC
W
F
G
L
A
KIGA
IM
VP
I
N
A
R
LL
R
E
E
S
A
W
I
L
QNS
QA
CLLVTS
A
QFYP
MYQ
QI
Q
-
--
--
---
Q
ED
A
T
QL
RH
I
CLT
D
VALP
A
D
DG
V
S
S
FT
QL
K
N
-
----------
Q
Q
PAT
LC
Y
A
P
P
LST
D
D
T
A
EI
LFTSGTT
S
R
PKGV
VI
TH
Y
N
LRF
A
G
Y
Y
S
AWQ
C
A
L
R
D
D
DVYL
TVM
PA
F
H
IDCQCT
A
AM
A
A
-----
F
S
AGAT
F
VL
VEKY
SA
R
A
F
WG
Q
V
Q
K
Y
R
A
T
I
T
ECI
P
M
M
IR
T
L
M
V
Q
P
P
SAN
D
RQ
H
R
L
RE
V
M
F
Y
L
-
--
-N
LS
EQEK
D
T
F
C
E
R
F
G
V
RLL
T
S
YGMTE
TIV
-
G
I
IG
---
-
D
R
P
GD
K
RRWP
S
I
GR
A
G
F
CY
-
---
D
AE
I
R
DD
HNR
PLP
A
GE
I
GE
ICI
KGVP
G
K
TI
F
K
E
YF
LN
P
K
A
TA
K
V
L
E
A
D
GW
L
H
T
GD
T
GYR
DEEG
FF
YFI
D
R
R
CN
M
I
K
RGGEN
V
S
CV
E
L
ENI
IA
T
HPKI
Q
D
I
V
VV
G
I
K
D
S
IR
D
E
A
IK
A
F
VVL
N
E
G
-
ET
LS
E
EE
F
F
RF
-C
EQ
N
M
AKFK
V
P
SY
L
E
IR
K
D
LPR
N
C
SGKI
I
R
K
N
L
fig|444450.8.peg.179
Escherichia coli O157:H7 str. EC4115 (12-516/517)
M
W
D
D
--
LAD
VY
G
HK
TA
L
I
CE
S
S
GG
VV
N
--
-
-R
YSY
L
ELNQ
EI
N
R
T
AN
LFYTL
GI
R
K
GD
KV
A
L
H
L
D
N
CP
EF
IFC
W
F
G
L
A
KIGA
IM
VP
I
N
A
R
LL
R
E
E
S
A
W
I
L
QNS
QA
CLLVTS
A
QFYP
MYQ
QI
Q
-
--
--
---
Q
ED
A
T
QL
RH
I
CLT
D
VALP
A
D
DG
V
S
S
FT
QL
K
N
-
----------
Q
Q
PAT
LC
Y
A
P
P
LST
D
D
T
A
EI
LFTSGTT
S
R
PKGV
VI
TH
Y
N
LRF
A
G
Y
Y
S
AWQ
C
A
L
R
D
D
DVYL
TVM
PA
F
H
IDCQCT
A
AM
A
A
-----
F
S
AGAT
F
VL
VEKY
SA
R
A
F
WG
Q
V
Q
K
Y
R
A
T
I
T
ECI
P
M
M
IR
T
L
M
V
Q
P
P
SAN
D
RQ
H
R
L
RE
V
M
F
Y
L
-
--
-N
LS
EQEK
D
T
F
C
E
R
F
G
V
RLL
T
S
YGMTE
TIV
-
G
I
IG
---
-
D
R
P
GD
K
RRWP
S
I
GR
A
G
F
CY
-
---
D
AE
I
R
DD
HNR
PLP
A
GE
I
GE
ICI
KGVP
G
K
TI
F
K
E
YF
LN
P
K
A
TA
K
V
L
E
A
D
GW
L
H
T
GD
T
GYR
DEEG
FF
YFI
D
R
R
CN
M
I
K
RGGEN
V
S
CV
E
L
ENI
IA
T
HPKI
Q
D
I
V
VV
G
I
K
D
S
IR
D
E
A
IK
A
F
VVL
N
E
G
-
ET
LS
E
EE
F
F
RF
-C
EQ
N
M
AKFK
V
P
SY
L
E
IR
K
D
LPR
N
C
SGKI
I
R
K
N
L
fig|444451.5.peg.4431
Escherichia coli O157:H7 str. EC4196 (12-516/517)
M
W
D
D
--
LAD
VY
G
HK
TA
L
I
CE
S
S
GG
VV
N
--
-
-R
YSY
L
ELNQ
EI
N
R
T
AN
LFYTL
GI
R
K
GD
KV
A
L
H
L
D
N
CP
EF
IFC
W
F
G
L
A
KIGA
IM
VP
I
N
A
R
LL
R
E
E
S
A
W
I
L
QNS
QA
CLLVTS
A
QFYP
MYQ
QI
Q
-
--
--
---
Q
ED
A
T
QL
RH
I
CLT
D
VALP
A
D
DG
V
S
S
FT
QL
K
N
-
----------
Q
Q
PAT
LC
Y
A
P
P
LST
D
D
T
A
EI
LFTSGTT
S
R
PKGV
VI
TH
Y
N
LRF
A
G
Y
Y
S
AWQ
C
A
L
R
D
D
DVYL
TVM
PA
F
H
IDCQCT
A
AM
A
A
-----
F
S
AGAT
F
VL
VEKY
SA
R
A
F
WG
Q
V
Q
K
Y
R
A
T
I
T
ECI
P
M
M
IR
T
L
M
V
Q
P
P
SAN
D
RQ
H
R
L
RE
V
M
F
Y
L
-
--
-N
LS
EQEK
D
T
F
C
E
R
F
G
V
RLL
T
S
YGMTE
TIV
-
G
I
IG
---
-
D
R
P
GD
K
RRWP
S
I
GR
A
G
F
CY
-
---
D
AE
I
R
DD
HNR
PLP
A
GE
I
GE
ICI
KGVP
G
K
TI
F
K
E
YF
LN
P
K
A
TA
K
V
L
E
A
D
GW
L
H
T
GD
T
GYR
DEEG
FF
YFI
D
R
R
CN
M
I
K
RGGEN
V
S
CV
E
L
ENI
IA
T
HPKI
Q
D
I
V
VV
G
I
K
D
S
IR
D
E
A
IK
A
F
VVL
N
E
G
-
ET
LS
E
EE
F
F
RF
-C
EQ
N
M
AKFK
V
P
SY
L
E
IR
K
D
LPR
N
C
SGKI
I
R
K
N
L
fig|444447.5.peg.2876
Escherichia coli O157:H7 str. EC4206 (12-516/517)
M
W
D
D
--
LAD
VY
G
HK
TA
L
I
CE
S
S
GG
VV
N
--
-
-R
YSY
L
ELNQ
EI
N
R
T
AN
LFYTL
GI
R
K
GD
KV
A
L
H
L
D
N
CP
EF
IFC
W
F
G
L
A
KIGA
IM
VP
I
N
A
R
LL
R
E
E
S
A
W
I
L
QNS
QA
CLLVTS
A
QFYP
MYQ
QI
Q
-
--
--
---
Q
ED
A
T
QL
RH
I
CLT
D
VALP
A
D
DG
V
S
S
FT
QL
K
N
-
----------
Q
Q
PAT
LC
Y
A
P
P
LST
D
D
T
A
EI
LFTSGTT
S
R
PKGV
VI
TH
Y
N
LRF
A
G
Y
Y
S
AWQ
C
A
L
R
D
D
DVYL
TVM
PA
F
H
IDCQCT
A
AM
A
A
-----
F
S
AGAT
F
VL
VEKY
SA
R
A
F
WG
Q
V
Q
K
Y
R
A
T
I
T
ECI
P
M
M
IR
T
L
M
V
Q
P
P
SAN
D
RQ
H
R
L
RE
V
M
F
Y
L
-
--
-N
LS
EQEK
D
T
F
C
E
R
F
G
V
RLL
T
S
YGMTE
TIV
-
G
I
IG
---
-
D
R
P
GD
K
RRWP
S
I
GR
A
G
F
CY
-
---
D
AE
I
R
DD
HNR
PLP
A
GE
I
GE
ICI
KGVP
G
K
TI
F
K
E
YF
LN
P
K
A
TA
K
V
L
E
A
D
GW
L
H
T
GD
T
GYR
DEEG
FF
YFI
D
R
R
CN
M
I
K
RGGEN
V
S
CV
E
L
ENI
IA
T
HPKI
Q
D
I
V
VV
G
I
K
D
S
IR
D
E
A
IK
A
F
VVL
N
E
G
-
ET
LS
E
EE
F
F
RF
-C
EQ
N
M
AKFK
V
P
SY
L
E
IR
K
D
LPR
N
C
SGKI
I
R
K
N
L
fig|478004.5.peg.3561
Escherichia coli O157:H7 str. EC4401 (12-516/517)
M
W
D
D
--
LAD
VY
G
HK
TA
L
I
CE
S
S
GG
VV
N
--
-
-R
YSY
L
ELNQ
EI
N
R
T
AN
LFYTL
GI
R
K
GD
KV
A
L
H
L
D
N
CP
EF
IFC
W
F
G
L
A
KIGA
IM
VP
I
N
A
R
LL
R
E
E
S
A
W
I
L
QNS
QA
CLLVTS
A
QFYP
MYQ
QI
Q
-
--
--
---
Q
ED
A
T
QL
RH
I
CLT
D
VALP
A
D
DG
V
S
S
FT
QL
K
N
-
----------
Q
Q
PAT
LC
Y
A
P
P
LST
D
D
T
A
EI
LFTSGTT
S
R
PKGV
VI
TH
Y
N
LRF
A
G
Y
Y
S
AWQ
C
A
L
R
D
D
DVYL
TVM
PA
F
H
IDCQCT
A
AM
A
A
-----
F
S
AGAT
F
VL
VEKY
SA
R
A
F
WG
Q
V
Q
K
Y
R
A
T
I
T
ECI
P
M
M
IR
T
L
M
V
Q
P
P
SAN
D
RQ
H
R
L
RE
V
M
F
Y
L
-
--
-N
LS
EQEK
D
T
F
C
E
R
F
G
V
RLL
T
S
YGMTE
TIV
-
G
I
IG
---
-
D
R
P
GD
K
RRWP
S
I
GR
A
G
F
CY
-
---
D
AE
I
R
DD
HNR
PLP
A
GE
I
GE
ICI
KGVP
G
K
TI
F
K
E
YF
LN
P
K
A
TA
K
V
L
E
A
D
GW
L
H
T
GD
T
GYR
DEEG
FF
YFI
D
R
R
CN
M
I
K
RGGEN
V
S
CV
E
L
ENI
IA
T
HPKI
Q
D
I
V
VV
G
I
K
D
S
IR
D
E
A
IK
A
F
VVL
N
E
G
-
ET
LS
E
EE
F
F
RF
-C
EQ
N
M
AKFK
V
P
SY
L
E
IR
K
D
LPR
N
C
SGKI
I
R
K
N
L
fig|478006.5.peg.3229
Escherichia coli O157:H7 str. EC4501 (12-516/517)
M
W
D
D
--
LAD
VY
G
HK
TA
L
I
CE
S
S
GG
VV
N
--
-
-R
YSY
L
ELNQ
EI
N
R
T
AN
LFYTL
GI
R
K
GD
KV
A
L
H
L
D
N
CP
EF
IFC
W
F
G
L
A
KIGA
IM
VP
I
N
A
R
LL
R
E
E
S
A
W
I
L
QNS
QA
CLLVTS
A
QFYP
MYQ
QI
Q
-
--
--
---
Q
ED
A
T
QL
RH
I
CLT
D
VALP
A
D
DG
V
S
S
FT
QL
K
N
-
----------
Q
Q
PAT
LC
Y
A
P
P
LST
D
D
T
A
EI
LFTSGTT
S
R
PKGV
VI
TH
Y
N
LRF
A
G
Y
Y
S
AWQ
C
A
L
R
D
D
DVYL
TVM
PA
F
H
IDCQCT
A
AM
A
A
-----
F
S
AGAT
F
VL
VEKY
SA
R
A
F
WG
Q
V
Q
K
Y
R
A
T
I
T
ECI
P
M
M
IR
T
L
M
V
Q
P
P
SAN
D
RQ
H
R
L
RE
V
M
F
Y
L
-
--
-N
LS
EQEK
D
T
F
C
E
R
F
G
V
RLL
T
S
YGMTE
TIV
-
G
I
IG
---
-
D
R
P
GD
K
RRWP
S
I
GR
A
G
F
CY
-
---
D
AE
I
R
DD
HNR
PLP
A
GE
I
GE
ICI
KGVP
G
K
TI
F
K
E
YF
LN
P
K
A
TA
K
V
L
E
A
D
GW
L
H
T
GD
T
GYR
DEEG
FF
YFI
D
R
R
CN
M
I
K
RGGEN
V
S
CV
E
L
ENI
IA
T
HPKI
Q
D
I
V
VV
G
I
K
D
S
IR
D
E
A
IK
A
F
VVL
N
E
G
-
ET
LS
E
EE
F
F
RF
-C
EQ
N
M
AKFK
V
P
SY
L
E
IR
K
D
LPR
N
C
SGKI
I
R
K
N
L
fig|478007.5.peg.4522
Escherichia coli O157:H7 str. EC508 (12-516/517)
M
W
D
D
--
LAD
VY
G
HK
TA
L
I
CE
S
S
GG
VV
N
--
-
-R
YSY
L
ELNQ
EI
N
R
T
AN
LFYTL
GI
R
K
GD
KV
A
L
H
L
D
N
CP
EF
IFC
W
F
G
L
A
KIGA
IM
VP
I
N
A
R
LL
R
E
E
S
A
W
I
L
QNS
QA
CLLVTS
A
QFYP
MYQ
QI
Q
-
--
--
---
Q
ED
A
T
QL
RH
I
CLT
D
VALP
A
D
DG
V
S
S
FT
QL
K
N
-
----------
Q
Q
PAT
LC
Y
A
P
P
LST
D
D
T
A
EI
LFTSGTT
S
R
PKGV
VI
TH
Y
N
LRF
A
G
Y
Y
S
AWQ
C
A
L
R
D
D
DVYL
TVM
PA
F
H
IDCQCT
A
AM
A
A
-----
F
S
AGAT
F
VL
VEKY
SA
R
A
F
WG
Q
V
Q
K
Y
R
A
T
I
T
ECI
P
M
M
IR
T
L
M
V
Q
P
P
SAN
D
RQ
H
R
L
RE
V
M
F
Y
L
-
--
-N
LS
EQEK
D
T
F
C
E
R
F
G
V
RLL
T
S
YGMTE
TIV
-
G
I
IG
---
-
D
R
P
GD
K
RRWP
S
I
GR
A
G
F
CY
-
---
D
AE
I
R
DD
HNR
PLP
A
GE
I
GE
ICI
KGVP
G
K
TI
F
K
E
YF
LN
P
K
A
TA
K
V
L
E
A
D
GW
L
H
T
GD
T
GYR
DEEG
FF
YFI
D
R
R
CN
M
I
K
RGGEN
V
S
CV
E
L
ENI
IA
T
HPKI
Q
D
I
V
VV
G
I
K
D
S
IR
D
E
A
IK
A
F
VVL
N
E
G
-
ET
LS
E
EE
F
F
RF
-C
EQ
N
M
AKFK
V
P
SY
L
E
IR
K
D
LPR
N
C
SGKI
I
R
K
N
L
fig|478008.5.peg.467
Escherichia coli O157:H7 str. EC869 (12-516/517)
M
W
D
D
--
LAD
VY
G
HK
TA
L
I
CE
S
S
GG
VV
N
--
-
-R
YSY
L
ELNQ
EI
N
R
T
AN
LFYTL
GI
R
K
GD
KV
A
L
H
L
D
N
CP
EF
IFC
W
F
G
L
A
KIGA
IM
VP
I
N
A
R
LL
R
E
E
S
A
W
I
L
QNS
QA
CLLVTS
A
QFYP
MYQ
QI
Q
-
--
--
---
Q
ED
A
T
QL
RH
I
CLT
D
VALP
A
D
DG
V
S
S
FT
QL
K
N
-
----------
Q
Q
PAT
LC
Y
A
P
P
LST
D
D
T
A
EI
LFTSGTT
S
R
PKGV
VI
TH
Y
N
LRF
A
G
Y
Y
S
AWQ
C
A
L
R
D
D
DVYL
TVM
PA
F
H
IDCQCT
A
AM
A
A
-----
F
S
AGAT
F
VL
VEKY
SA
R
A
F
WG
Q
V
Q
K
Y
R
A
T
I
T
ECI
P
M
M
IR
T
L
M
V
Q
P
P
SAN
D
RQ
H
R
L
RE
V
M
F
Y
L
-
--
-N
LS
EQEK
D
T
F
C
E
R
F
G
V
RLL
T
S
YGMTE
TIV
-
G
I
IG
---
-
D
R
P
GD
K
RRWP
S
I
GR
A
G
F
CY
-
---
D
AE
I
R
DD
HNR
PLP
A
GE
I
GE
ICI
KGVP
G
K
TI
F
K
E
YF
LN
P
K
A
TA
K
V
L
E
A
D
GW
L
H
T
GD
T
GYR
DEEG
FF
YFI
D
R
R
CN
M
I
K
RGGEN
V
S
CV
E
L
ENI
IA
T
HPKI
Q
D
I
V
VV
G
I
K
D
S
IR
D
E
A
IK
A
F
VVL
N
E
G
-
ET
LS
E
EE
F
F
RF
-C
EQ
N
M
AKFK
V
P
SY
L
E
IR
K
D
LPR
N
C
SGKI
I
R
K
N
L
fig|637388.3.peg.3876
Escherichia coli O157:H7 str. FRIK2000 (12-516/517)
M
W
D
D
--
LAD
VY
G
HK
TA
L
I
CE
S
S
GG
VV
N
--
-
-R
YSY
L
ELNQ
EI
N
R
T
AN
LFYTL
GI
R
K
GD
KV
A
L
H
L
D
N
CP
EF
IFC
W
F
G
L
A
KIGA
IM
VP
I
N
A
R
LL
R
E
E
S
A
W
I
L
QNS
QA
CLLVTS
A
QFYP
MYQ
QI
Q
-
--
--
---
Q
ED
A
T
QL
RH
I
CLT
D
VALP
A
D
DG
V
S
S
FT
QL
K
N
-
----------
Q
Q
PAT
LC
Y
A
P
P
LST
D
D
T
A
EI
LFTSGTT
S
R
PKGV
VI
TH
Y
N
LRF
A
G
Y
Y
S
AWQ
C
A
L
R
D
D
DVYL
TVM
PA
F
H
IDCQCT
A
AM
A
A
-----
F
S
AGAT
F
VL
VEKY
SA
R
A
F
WG
Q
V
Q
K
Y
R
A
T
I
T
ECI
P
M
M
IR
T
L
M
V
Q
P
P
SAN
D
RQ
H
R
L
RE
V
M
F
Y
L
-
--
-N
LS
EQEK
D
T
F
C
E
R
F
G
V
RLL
T
S
YGMTE
TIV
-
G
I
IG
---
-
D
R
P
GD
K
RRWP
S
I
GR
A
G
F
CY
-
---
D
AE
I
R
DD
HNR
PLP
A
GE
I
GE
ICI
KGVP
G
K
TI
F
K
E
YF
LN
P
K
A
TA
K
V
L
E
A
D
GW
L
H
T
GD
T
GYR
DEEG
FF
YFI
D
R
R
CN
M
I
K
RGGEN
V
S
CV
E
L
ENI
IA
T
HPKI
Q
D
I
V
VV
G
I
K
D
S
IR
D
E
A
IK
A
F
VVL
N
E
G
-
ET
LS
E
EE
F
F
RF
-C
EQ
N
M
AKFK
V
P
SY
L
E
IR
K
D
LPR
N
C
SGKI
I
R
K
N
L
fig|570506.3.peg.1040
Escherichia coli O157:H7 str. FRIK966 (12-516/517)
M
W
D
D
--
LAD
VY
G
HK
TA
L
I
CE
S
S
GG
VV
N
--
-
-R
YSY
L
ELNQ
EI
N
R
T
AN
LFYTL
GI
R
K
GD
KV
A
L
H
L
D
N
CP
EF
IFC
W
F
G
L
A
KIGA
IM
VP
I
N
A
R
LL
R
E
E
S
A
W
I
L
QNS
QA
CLLVTS
A
QFYP
MYQ
QI
Q
-
--
--
---
Q
ED
A
T
QL
RH
I
CLT
D
VALP
A
D
DG
V
S
S
FT
QL
K
N
-
----------
Q
Q
PAT
LC
Y
A
P
P
LST
D
D
T
A
EI
LFTSGTT
S
R
PKGV
VI
TH
Y
N
LRF
A
G
Y
Y
S
AWQ
C
A
L
R
D
D
DVYL
TVM
PA
F
H
IDCQCT
A
AM
A
A
-----
F
S
AGAT
F
VL
VEKY
SA
R
A
F
WG
Q
V
Q
K
Y
R
A
T
I
T
ECI
P
M
M
IR
T
L
M
V
Q
P
P
SAN
D
RQ
H
R
L
RE
V
M
F
Y
L
-
--
-N
LS
EQEK
D
T
F
C
E
R
F
G
V
RLL
T
S
YGMTE
TIV
-
G
I
IG
---
-
D
R
P
GD
K
RRWP
S
I
GR
A
G
F
CY
-
---
D
AE
I
R
DD
HNR
PLP
A
GE
I
GE
ICI
KGVP
G
K
TI
F
K
E
YF
LN
P
K
A
TA
K
V
L
E
A
D
GW
L
H
T
GD
T
GYR
DEEG
FF
YFI
D
R
R
CN
M
I
K
RGGEN
V
S
CV
E
L
ENI
IA
T
HPKI
Q
D
I
V
VV
G
I
K
D
S
IR
D
E
A
IK
A
F
VVL
N
E
G
-
ET
LS
E
EE
F
F
RF
-C
EQ
N
M
AKFK
V
P
SY
L
E
IR
K
D
LPR
N
C
SGKI
I
R
K
N
L
fig|386585.9.peg.137
Escherichia coli O157:H7 str. Sakai (12-516/517)
M
W
D
D
--
LAD
VY
G
HK
TA
L
I
CE
S
S
GG
VV
N
--
-
-R
YSY
L
ELNQ
EI
N
R
T
AN
LFYTL
GI
R
K
GD
KV
A
L
H
L
D
N
CP
EF
IFC
W
F
G
L
A
KIGA
IM
VP
I
N
A
R
LL
R
E
E
S
A
W
I
L
QNS
QA
CLLVTS
A
QFYP
MYQ
QI
Q
-
--
--
---
Q
ED
A
T
QL
RH
I
CLT
D
VALP
A
D
DG
V
S
S
FT
QL
K
N
-
----------
Q
Q
PAT
LC
Y
A
P
P
LST
D
D
T
A
EI
LFTSGTT
S
R
PKGV
VI
TH
Y
N
LRF
A
G
Y
Y
S
AWQ
C
A
L
R
D
D
DVYL
TVM
PA
F
H
IDCQCT
A
AM
A
A
-----
F
S
AGAT
F
VL
VEKY
SA
R
A
F
WG
Q
V
Q
K
Y
R
A
T
I
T
ECI
P
M
M
IR
T
L
M
V
Q
P
P
SAN
D
RQ
H
R
L
RE
V
M
F
Y
L
-
--
-N
LS
EQEK
D
T
F
C
E
R
F
G
V
RLL
T
S
YGMTE
TIV
-
G
I
IG
---
-
D
R
P
GD
K
RRWP
S
I
GR
A
G
F
CY
-
---
D
AE
I
R
DD
HNR
PLP
A
GE
I
GE
ICI
KGVP
G
K
TI
F
K
E
YF
LN
P
K
A
TA
K
V
L
E
A
D
GW
L
H
T
GD
T
GYR
DEEG
FF
YFI
D
R
R
CN
M
I
K
RGGEN
V
S
CV
E
L
ENI
IA
T
HPKI
Q
D
I
V
VV
G
I
K
D
S
IR
D
E
A
IK
A
F
VVL
N
E
G
-
ET
LS
E
EE
F
F
RF
-C
EQ
N
M
AKFK
V
P
SY
L
E
IR
K
D
LPR
N
C
SGKI
I
R
K
N
L
fig|544404.4.peg.41
Escherichia coli O157:H7 str. TW14359 (12-516/517)
M
W
D
D
--
LAD
VY
G
HK
TA
L
I
CE
S
S
GG
VV
N
--
-
-R
YSY
L
ELNQ
EI
N
R
T
AN
LFYTL
GI
R
K
GD
KV
A
L
H
L
D
N
CP
EF
IFC
W
F
G
L
A
KIGA
IM
VP
I
N
A
R
LL
R
E
E
S
A
W
I
L
QNS
QA
CLLVTS
A
QFYP
MYQ
QI
Q
-
--
--
---
Q
ED
A
T
QL
RH
I
CLT
D
VALP
A
D
DG
V
S
S
FT
QL
K
N
-
----------
Q
Q
PAT
LC
Y
A
P
P
LST
D
D
T
A
EI
LFTSGTT
S
R
PKGV
VI
TH
Y
N
LRF
A
G
Y
Y
S
AWQ
C
A
L
R
D
D
DVYL
TVM
PA
F
H
IDCQCT
A
AM
A
A
-----
F
S
AGAT
F
VL
VEKY
SA
R
A
F
WG
Q
V
Q
K
Y
R
A
T
I
T
ECI
P
M
M
IR
T
L
M
V
Q
P
P
SAN
D
RQ
H
R
L
RE
V
M
F
Y
L
-
--
-N
LS
EQEK
D
T
F
C
E
R
F
G
V
RLL
T
S
YGMTE
TIV
-
G
I
IG
---
-
D
R
P
GD
K
RRWP
S
I
GR
A
G
F
CY
-
---
D
AE
I
R
DD
HNR
PLP
A
GE
I
GE
ICI
KGVP
G
K
TI
F
K
E
YF
LN
P
K
A
TA
K
V
L
E
A
D
GW
L
H
T
GD
T
GYR
DEEG
FF
YFI
D
R
R
CN
M
I
K
RGGEN
V
S
CV
E
L
ENI
IA
T
HPKI
Q
D
I
V
VV
G
I
K
D
S
IR
D
E
A
IK
A
F
VVL
N
E
G
-
ET
LS
E
EE
F
F
RF
-C
EQ
N
M
AKFK
V
P
SY
L
E
IR
K
D
LPR
N
C
SGKI
I
R
K
N
L
fig|502346.5.peg.1226
Escherichia coli O157:H7 str. TW14588 (12-516/517)
M
W
D
D
--
LAD
VY
G
HK
TA
L
I
CE
S
S
GG
VV
N
--
-
-R
YSY
L
ELNQ
EI
N
R
T
AN
LFYTL
GI
R
K
GD
KV
A
L
H
L
D
N
CP
EF
IFC
W
F
G
L
A
KIGA
IM
VP
I
N
A
R
LL
R
E
E
S
A
W
I
L
QNS
QA
CLLVTS
A
QFYP
MYQ
QI
Q
-
--
--
---
Q
ED
A
T
QL
RH
I
CLT
D
VALP
A
D
DG
V
S
S
FT
QL
K
N
-
----------
Q
Q
PAT
LC
Y
A
P
P
LST
D
D
T
A
EI
LFTSGTT
S
R
PKGV
VI
TH
Y
N
LRF
A
G
Y
Y
S
AWQ
C
A
L
R
D
D
DVYL
TVM
PA
F
H
IDCQCT
A
AM
A
A
-----
F
S
AGAT
F
VL
VEKY
SA
R
A
F
WG
Q
V
Q
K
Y
R
A
T
I
T
ECI
P
M
M
IR
T
L
M
V
Q
P
P
SAN
D
RQ
H
R
L
RE
V
M
F
Y
L
-
--
-N
LS
EQEK
D
T
F
C
E
R
F
G
V
RLL
T
S
YGMTE
TIV
-
G
I
IG
---
-
D
R
P
GD
K
RRWP
S
I
GR
A
G
F
CY
-
---
D
AE
I
R
DD
HNR
PLP
A
GE
I
GE
ICI
KGVP
G
K
TI
F
K
E
YF
LN
P
K
A
TA
K
V
L
E
A
D
GW
L
H
T
GD
T
GYR
DEEG
FF
YFI
D
R
R
CN
M
I
K
RGGEN
V
S
CV
E
L
ENI
IA
T
HPKI
Q
D
I
V
VV
G
I
K
D
S
IR
D
E
A
IK
A
F
VVL
N
E
G
-
ET
LS
E
EE
F
F
RF
-C
EQ
N
M
AKFK
V
P
SY
L
E
IR
K
D
LPR
N
C
SGKI
I
R
K
N
L
fig|358709.5.peg.4447
Escherichia coli 101-1 (12-516/517)
M
W
D
D
--
LAD
VY
G
HK
TA
L
I
CE
S
S
GG
VV
N
--
-
-R
YSY
L
ELNQ
EI
N
R
T
AN
LFYTL
GI
R
K
GD
KV
A
L
H
L
D
N
CP
EF
IFC
W
F
G
L
A
KIGA
IM
VP
I
N
A
R
LL
R
E
E
S
A
W
I
L
QNS
QA
CLLVTS
A
QFYP
MYQ
QI
Q
-
--
--
---
Q
ED
A
T
QL
RH
I
CLT
D
VALP
A
D
DG
V
S
S
FT
QL
K
N
-
----------
Q
Q
PAT
LC
Y
A
P
P
LST
D
D
T
A
EI
LFTSGTT
S
R
PKGV
VI
TH
Y
N
LRF
A
G
Y
Y
S
AWQ
C
A
L
R
D
D
DVYL
TVM
PA
F
H
IDCQCT
A
AM
A
A
-----
F
S
AGAT
F
VL
VEKY
SA
R
A
F
WG
Q
V
Q
K
Y
R
A
T
V
T
ECI
P
M
M
IR
T
L
M
V
Q
P
P
SAN
D
RQ
H
R
L
RE
V
M
F
Y
L
-
--
-N
LS
EQEK
DA
F
C
E
R
F
G
V
RLL
T
S
YGMTE
TIV
-
G
I
IG
---
-
D
R
P
GD
K
RRWP
S
I
GR
A
G
F
CY
-
---
E
AE
I
R
DD
HNC
PLP
A
GE
I
GE
ICI
KGVP
G
K
TI
F
K
E
YF
LN
P
K
A
TA
K
V
L
E
A
D
GW
L
H
T
GD
T
GYR
DEEG
FF
YFV
D
R
R
CN
M
I
K
RGGEN
V
S
CV
E
L
ENI
IA
T
HPKI
Q
D
I
V
VV
G
I
K
D
S
IR
D
E
A
IK
A
F
VVL
N
E
G
-
ET
LS
E
EE
F
F
RF
-C
EQ
N
M
AKFK
V
P
SY
L
E
IR
K
D
LPR
N
C
SGKI
I
R
K
N
L
fig|344610.7.peg.1705
Escherichia coli 53638 (12-516/517)
M
W
D
D
--
LAD
VY
G
HK
TA
L
I
CE
S
S
GG
VV
N
--
-
-R
YSY
L
ELNQ
EI
N
R
T
AN
LFYTL
GI
R
K
GD
KV
A
L
H
L
D
N
CP
EF
IFC
W
F
G
L
A
KIGA
IM
VP
I
N
A
R
LL
R
E
E
S
A
W
I
L
QNS
QA
CLLVTS
A
QFYP
MYQ
QI
Q
-
--
--
---
Q
ED
A
T
QL
RH
I
CLT
D
VALP
A
D
DG
V
S
S
FT
QL
K
N
-
----------
Q
Q
PAT
LC
Y
A
P
P
LST
D
D
T
A
EI
LFTSGTT
S
R
PKGV
VI
TH
Y
N
LRF
A
G
Y
Y
S
AWQ
C
A
L
R
D
D
DVYL
TVM
PA
F
H
IDCQCT
A
AM
A
A
-----
F
S
AGAT
F
VL
VEKY
SA
R
A
F
WG
Q
V
Q
K
Y
R
A
T
V
T
ECI
P
M
M
IR
T
L
M
V
Q
P
P
SAN
D
RQ
H
R
L
RE
V
M
F
Y
L
-
--
-N
LS
EQEK
DA
F
C
E
R
F
G
V
RLL
T
S
YGMTE
TIV
-
G
I
IG
---
-
D
R
P
GD
K
RRWP
S
I
GR
A
G
F
CY
-
---
E
AE
I
R
DD
HNC
PLP
A
GE
I
GE
ICI
KGVP
G
K
TI
F
K
E
YF
LN
P
K
A
TA
K
V
L
E
A
D
GW
L
H
T
GD
T
GYR
DEEG
FF
YFV
D
R
R
CN
M
I
K
RGGEN
V
S
CV
E
L
ENI
IA
T
HPKI
Q
D
I
V
VV
G
I
K
D
S
IR
D
E
A
IK
A
F
VVL
N
E
G
-
ET
LS
E
EE
F
F
RF
-C
EQ
N
M
AKFK
V
P
SY
L
E
IR
K
D
LPR
N
C
SGKI
I
R
K
N
L
fig|316401.4.peg.42
Escherichia coli ETEC H10407 (12-516/517)
M
W
D
D
--
LAD
VY
G
HK
TA
L
I
CE
S
S
GG
VV
N
--
-
-R
YSY
L
ELNQ
EI
N
R
T
AN
LFYTL
GI
R
K
GD
KV
A
L
H
L
D
N
CP
EF
IFC
W
F
G
L
A
KIGA
IM
VP
I
N
A
R
LL
R
E
E
S
A
W
I
L
QNS
QA
CLLVTS
A
QFYP
MYQ
QI
Q
-
--
--
---
Q
ED
A
T
QL
RH
I
CLT
D
VALP
A
D
DG
V
S
S
FT
QL
K
N
-
----------
Q
Q
PAT
LC
Y
A
P
P
LST
D
D
T
A
EI
LFTSGTT
S
R
PKGV
VI
TH
Y
N
LRF
A
G
Y
Y
S
AWQ
C
A
L
R
D
D
DVYL
TVM
PA
F
H
IDCQCT
A
AM
A
A
-----
F
S
AGAT
F
VL
VEKY
SA
R
A
F
WG
Q
V
Q
K
Y
R
A
T
V
T
ECI
P
M
M
IR
T
L
M
V
Q
P
P
SAN
D
RQ
H
R
L
RE
V
M
F
Y
L
-
--
-N
LS
EQEK
DA
F
C
E
R
F
G
V
RLL
T
S
YGMTE
TIV
-
G
I
IG
---
-
D
R
P
GD
K
RRWP
S
I
GR
A
G
F
CY
-
---
E
AE
I
R
DD
HNC
PLP
A
GE
I
GE
ICI
KGVP
G
K
TI
F
K
E
YF
LN
P
K
A
TA
K
V
L
E
A
D
GW
L
H
T
GD
T
GYR
DEEG
FF
YFV
D
R
R
CN
M
I
K
RGGEN
V
S
CV
E
L
ENI
IA
T
HPKI
Q
D
I
V
VV
G
I
K
D
S
IR
D
E
A
IK
A
F
VVL
N
E
G
-
ET
LS
E
EE
F
F
RF
-C
EQ
N
M
AKFK
V
P
SY
L
E
IR
K
D
LPR
N
C
SGKI
I
R
K
N
L
fig|749537.3.peg.3127
Escherichia coli MS 115-1 (12-516/517)
M
W
D
D
--
LAD
VY
G
HK
TA
L
I
CE
S
S
GG
VV
N
--
-
-R
YSY
L
ELNQ
EI
N
R
T
AN
LFYTL
GI
R
K
GD
KV
A
L
H
L
D
N
CP
EF
IFC
W
F
G
L
A
KIGA
IM
VP
I
N
A
R
LL
R
E
E
S
A
W
I
L
QNS
QA
CLLVTS
A
QFYP
MYQ
QI
Q
-
--
--
---
Q
ED
A
T
QL
RH
I
CLT
D
VALP
A
D
DG
V
S
S
FT
QL
K
N
-
----------
Q
Q
PAT
LC
Y
A
P
P
LST
D
D
T
A
EI
LFTSGTT
S
R
PKGV
VI
TH
Y
N
LRF
A
G
Y
Y
S
AWQ
C
A
L
R
D
D
DVYL
TVM
PA
F
H
IDCQCT
A
AM
A
A
-----
F
S
AGAT
F
VL
VEKY
SA
R
A
F
WG
Q
V
Q
K
Y
R
A
T
V
T
ECI
P
M
M
IR
T
L
M
V
Q
P
P
SAN
D
RQ
H
R
L
RE
V
M
F
Y
L
-
--
-N
LS
EQEK
DA
F
C
E
R
F
G
V
RLL
T
S
YGMTE
TIV
-
G
I
IG
---
-
D
R
P
GD
K
RRWP
S
I
GR
A
G
F
CY
-
---
E
AE
I
R
DD
HNC
PLP
A
GE
I
GE
ICI
KGVP
G
K
TI
F
K
E
YF
LN
P
K
A
TA
K
V
L
E
A
D
GW
L
H
T
GD
T
GYR
DEEG
FF
YFV
D
R
R
CN
M
I
K
RGGEN
V
S
CV
E
L
ENI
IA
T
HPKI
Q
D
I
V
VV
G
I
K
D
S
IR
D
E
A
IK
A
F
VVL
N
E
G
-
ET
LS
E
EE
F
F
RF
-C
EQ
N
M
AKFK
V
P
SY
L
E
IR
K
D
LPR
N
C
SGKI
I
R
K
N
L
fig|749547.3.peg.991
Escherichia coli MS 187-1 (12-516/517)
M
W
D
D
--
LAD
VY
G
HK
TA
L
I
CE
S
S
GG
VV
N
--
-
-R
YSY
L
ELNQ
EI
N
R
T
AN
LFYTL
GI
R
K
GD
KV
A
L
H
L
D
N
CP
EF
IFC
W
F
G
L
A
KIGA
IM
VP
I
N
A
R
LL
R
E
E
S
A
W
I
L
QNS
QA
CLLVTS
A
QFYP
MYQ
QI
Q
-
--
--
---
Q
ED
A
T
QL
RH
I
CLT
D
VALP
A
D
DG
V
S
S
FT
QL
K
N
-
----------
Q
Q
PAT
LC
Y
A
P
P
LST
D
D
T
A
EI
LFTSGTT
S
R
PKGV
VI
TH
Y
N
LRF
A
G
Y
Y
S
AWQ
C
A
L
R
D
D
DVYL
TVM
PA
F
H
IDCQCT
A
AM
A
A
-----
F
S
AGAT
F
VL
VEKY
SA
R
A
F
WG
Q
V
Q
K
Y
R
A
T
V
T
ECI
P
M
M
IR
T
L
M
V
Q
P
P
SAN
D
RQ
H
R
L
RE
V
M
F
Y
L
-
--
-N
LS
EQEK
DA
F
C
E
R
F
G
V
RLL
T
S
YGMTE
TIV
-
G
I
IG
---
-
D
R
P
GD
K
RRWP
S
I
GR
A
G
F
CY
-
---
E
AE
I
R
DD
HNC
PLP
A
GE
I
GE
ICI
KGVP
G
K
TI
F
K
E
YF
LN
P
K
A
TA
K
V
L
E
A
D
GW
L
H
T
GD
T
GYR
DEEG
FF
YFV
D
R
R
CN
M
I
K
RGGEN
V
S
CV
E
L
ENI
IA
T
HPKI
Q
D
I
V
VV
G
I
K
D
S
IR
D
E
A
IK
A
F
VVL
N
E
G
-
ET
LS
E
EE
F
F
RF
-C
EQ
N
M
AKFK
V
P
SY
L
E
IR
K
D
LPR
N
C
SGKI
I
R
K
N
L
fig|344610.3.peg.786
Escherichia coli 53638 (17-521/522)
M
W
D
D
--
LAD
VY
G
HK
TA
L
I
CE
S
S
GG
VV
N
--
-
-R
YSY
L
ELNQ
EI
N
R
T
AN
LFYTL
GI
R
K
GD
KV
A
L
H
L
D
N
CP
EF
IFC
W
F
G
L
A
KIGA
IM
VP
I
N
A
R
LL
R
E
E
S
A
W
I
L
QNS
QA
CLLVTS
A
QFYP
MYQ
QI
Q
-
--
--
---
Q
ED
A
T
QL
RH
I
CLT
D
VALP
A
D
DG
V
S
S
FT
QL
K
N
-
----------
Q
Q
PAT
LC
Y
A
P
P
LST
D
D
T
A
EI
LFTSGTT
S
R
PKGV
VI
TH
Y
N
LRF
A
G
Y
Y
S
AWQ
C
A
L
R
D
D
DVYL
TVM
PA
F
H
IDCQCT
A
AM
A
A
-----
F
S
AGAT
F
VL
VEKY
SA
R
A
F
WG
Q
V
Q
K
Y
R
A
T
V
T
ECI
P
M
M
IR
T
L
M
V
Q
P
P
SAN
D
RQ
H
R
L
RE
V
M
F
Y
L
-
--
-N
LS
EQEK
DA
F
C
E
R
F
G
V
RLL
T
S
YGMTE
TIV
-
G
I
IG
---
-
D
R
P
GD
K
RRWP
S
I
GR
A
G
F
CY
-
---
E
AE
I
R
DD
HNC
PLP
A
GE
I
GE
ICI
KGVP
G
K
TI
F
K
E
YF
LN
P
K
A
TA
K
V
L
E
A
D
GW
L
H
T
GD
T
GYR
DEEG
FF
YFV
D
R
R
CN
M
I
K
RGGEN
V
S
CV
E
L
ENI
IA
T
HPKI
Q
D
I
V
VV
G
I
K
D
S
IR
D
E
A
IK
A
F
VVL
N
E
G
-
ET
LS
E
EE
F
F
RF
-C
EQ
N
M
AKFK
V
P
SY
L
E
IR
K
D
LPR
N
C
SGKI
I
R
K
N
L
fig|413997.3.peg.41
Escherichia coli B str. REL606 (12-516/517)
M
W
D
D
--
LAD
VY
G
HK
TA
L
I
CE
S
S
GG
VV
N
--
-
-R
YSY
L
ELNQ
EI
N
R
T
AN
LFYTL
GI
R
K
GD
KV
A
L
H
L
D
N
CP
EF
IFC
W
F
G
L
A
KIGA
IM
VP
I
N
A
C
LL
R
E
E
S
A
W
I
L
QNS
QA
CLLVTS
A
QFYP
MYQ
QI
Q
-
--
--
---
Q
ED
A
T
QL
RH
I
CLT
D
VALP
A
D
DG
V
S
S
FT
QL
K
N
-
----------
Q
Q
PAT
LC
Y
A
P
P
LST
D
D
T
A
EI
LFTSGTT
S
R
PKGV
VI
TH
Y
N
LRF
A
G
Y
Y
S
AWQ
C
A
L
R
D
D
DVYL
TVM
PA
F
H
IDCQCT
A
AM
A
A
-----
F
S
AGAT
F
VL
VEKY
SA
R
A
F
WG
Q
V
Q
K
Y
R
A
T
V
T
ECI
P
M
M
IR
T
L
M
V
Q
P
P
SAN
D
RQ
H
R
L
RE
V
M
F
Y
L
-
--
-N
LS
EQEK
DA
F
C
E
R
F
G
V
RLL
T
S
YGMTE
TIV
-
G
I
IG
---
-
D
R
P
GD
K
RRWP
S
I
GR
A
G
F
CY
-
---
E
AE
I
R
DD
HNC
PLP
A
GE
I
GE
ICI
KGVP
G
K
TI
F
K
E
YF
LN
P
K
A
TA
K
V
L
E
A
D
GW
L
H
T
GD
T
GYR
DEEG
FF
YFV
D
R
R
CN
M
I
K
RGGEN
V
S
CV
E
L
ENI
IA
T
HPKI
Q
D
I
V
VV
G
I
K
D
S
IR
D
E
A
IK
A
F
VVL
N
E
G
-
ET
LS
E
EE
F
F
RF
-C
EQ
N
M
AKFK
V
P
SY
L
E
IR
K
D
LPR
N
C
SGKI
I
R
K
N
L
fig|511693.5.peg.42
Escherichia coli BL21 (12-516/517)
M
W
D
D
--
LAD
VY
G
HK
TA
L
I
CE
S
S
GG
VV
N
--
-
-R
YSY
L
ELNQ
EI
N
R
T
AN
LFYTL
GI
R
K
GD
KV
A
L
H
L
D
N
CP
EF
IFC
W
F
G
L
A
KIGA
IM
VP
I
N
A
C
LL
R
E
E
S
A
W
I
L
QNS
QA
CLLVTS
A
QFYP
MYQ
QI
Q
-
--
--
---
Q
ED
A
T
QL
RH
I
CLT
D
VALP
A
D
DG
V
S
S
FT
QL
K
N
-
----------
Q
Q
PAT
LC
Y
A
P
P
LST
D
D
T
A
EI
LFTSGTT
S
R
PKGV
VI
TH
Y
N
LRF
A
G
Y
Y
S
AWQ
C
A
L
R
D
D
DVYL
TVM
PA
F
H
IDCQCT
A
AM
A
A
-----
F
S
AGAT
F
VL
VEKY
SA
R
A
F
WG
Q
V
Q
K
Y
R
A
T
V
T
ECI
P
M
M
IR
T
L
M
V
Q
P
P
SAN
D
RQ
H
R
L
RE
V
M
F
Y
L
-
--
-N
LS
EQEK
DA
F
C
E
R
F
G
V
RLL
T
S
YGMTE
TIV
-
G
I
IG
---
-
D
R
P
GD
K
RRWP
S
I
GR
A
G
F
CY
-
---
E
AE
I
R
DD
HNC
PLP
A
GE
I
GE
ICI
KGVP
G
K
TI
F
K
E
YF
LN
P
K
A
TA
K
V
L
E
A
D
GW
L
H
T
GD
T
GYR
DEEG
FF
YFV
D
R
R
CN
M
I
K
RGGEN
V
S
CV
E
L
ENI
IA
T
HPKI
Q
D
I
V
VV
G
I
K
D
S
IR
D
E
A
IK
A
F
VVL
N
E
G
-
ET
LS
E
EE
F
F
RF
-C
EQ
N
M
AKFK
V
P
SY
L
E
IR
K
D
LPR
N
C
SGKI
I
R
K
N
L
fig|469008.4.peg.3703
Escherichia coli BL21(DE3) (12-516/517)
M
W
D
D
--
LAD
VY
G
HK
TA
L
I
CE
S
S
GG
VV
N
--
-
-R
YSY
L
ELNQ
EI
N
R
T
AN
LFYTL
GI
R
K
GD
KV
A
L
H
L
D
N
CP
EF
IFC
W
F
G
L
A
KIGA
IM
VP
I
N
A
C
LL
R
E
E
S
A
W
I
L
QNS
QA
CLLVTS
A
QFYP
MYQ
QI
Q
-
--
--
---
Q
ED
A
T
QL
RH
I
CLT
D
VALP
A
D
DG
V
S
S
FT
QL
K
N
-
----------
Q
Q
PAT
LC
Y
A
P
P
LST
D
D
T
A
EI
LFTSGTT
S
R
PKGV
VI
TH
Y
N
LRF
A
G
Y
Y
S
AWQ
C
A
L
R
D
D
DVYL
TVM
PA
F
H
IDCQCT
A
AM
A
A
-----
F
S
AGAT
F
VL
VEKY
SA
R
A
F
WG
Q
V
Q
K
Y
R
A
T
V
T
ECI
P
M
M
IR
T
L
M
V
Q
P
P
SAN
D
RQ
H
R
L
RE
V
M
F
Y
L
-
--
-N
LS
EQEK
DA
F
C
E
R
F
G
V
RLL
T
S
YGMTE
TIV
-
G
I
IG
---
-
D
R
P
GD
K
RRWP
S
I
GR
A
G
F
CY
-
---
E
AE
I
R
DD
HNC
PLP
A
GE
I
GE
ICI
KGVP
G
K
TI
F
K
E
YF
LN
P
K
A
TA
K
V
L
E
A
D
GW
L
H
T
GD
T
GYR
DEEG
FF
YFV
D
R
R
CN
M
I
K
RGGEN
V
S
CV
E
L
ENI
IA
T
HPKI
Q
D
I
V
VV
G
I
K
D
S
IR
D
E
A
IK
A
F
VVL
N
E
G
-
ET
LS
E
EE
F
F
RF
-C
EQ
N
M
AKFK
V
P
SY
L
E
IR
K
D
LPR
N
C
SGKI
I
R
K
N
L
fig|656419.3.peg.191
Escherichia coli M718 (12-516/517)
M
W
D
D
--
LAD
VY
G
HK
TA
L
I
CE
S
S
GG
VV
N
--
-
-R
YSY
L
ELNQ
EI
N
R
T
AN
LFYTL
GI
R
K
GD
KV
A
L
H
L
D
N
CP
EF
IFC
W
F
G
L
A
KIGA
IM
VP
I
N
A
R
LL
R
E
E
S
T
W
I
L
QNS
QA
CLLVTS
A
QFYP
MYQ
QI
Q
-
--
--
---
Q
ED
A
S
QL
RH
I
CLT
D
MALP
A
D
DG
V
S
S
FT
QL
K
N
-
----------
Q
Q
PAT
LC
Y
A
P
P
LST
D
D
T
A
EI
LFTSGTT
S
R
PKGV
VI
TH
Y
N
LRF
A
G
Y
Y
S
AWQ
C
A
L
R
D
D
DVYL
TVM
PA
F
H
IDCQCT
A
AM
A
A
-----
F
S
AGAT
F
VL
VEKY
SA
R
A
F
WG
Q
V
Q
K
Y
R
A
T
I
T
ECI
P
M
M
IR
T
L
M
V
Q
P
P
SAN
D
RQ
H
C
L
RE
V
M
F
Y
L
-
--
-N
LS
EQEK
DA
F
C
E
R
F
S
V
RLL
T
S
YGMTE
TIV
-
G
I
IG
---
-
D
R
P
GD
K
RRWP
S
I
GR
A
G
F
CY
-
---
E
AE
I
R
DD
HNR
PLP
A
GE
L
GE
ICI
KGVP
G
K
TI
F
K
E
YF
LN
P
K
A
TA
K
V
L
E
A
D
GW
L
H
T
GD
T
GYR
DEEG
FF
YFV
D
R
R
CN
M
I
K
RGGEN
V
S
CV
E
L
ENI
IA
A
HPKI
Q
D
I
V
VV
G
I
K
D
S
IR
D
E
A
IK
A
F
VVL
N
E
G
-
ET
LS
E
EE
F
F
RF
-C
EQ
N
M
AKFK
V
P
SY
L
E
IR
K
D
LPR
N
C
SGKI
I
R
K
N
L
fig|670888.3.peg.616
Escherichia coli 1827-70 (12-516/517)
M
W
D
D
--
LAD
VY
G
HK
TA
L
I
CE
S
S
GG
VV
N
--
-
-R
YSY
L
ELNQ
EI
N
R
T
AN
LFYTL
GI
R
K
GD
KV
A
L
H
L
D
N
CP
EF
IFC
W
F
G
L
A
KIGA
IM
VP
I
N
A
R
LL
C
E
E
S
A
W
I
L
QNS
QA
CLLVTS
A
QFYP
MYQ
QI
Q
-
--
--
---
Q
ED
A
T
QL
RH
I
CLT
D
VALP
A
D
DG
V
S
S
FT
QL
K
N
-
----------
Q
Q
PAT
LC
Y
A
P
P
LST
D
D
T
A
EI
LFTSGTT
S
R
PKGV
VI
TH
Y
N
LRF
A
G
Y
Y
S
AWQ
C
A
L
R
D
D
DVYL
TVM
PA
F
H
IDCQCT
A
AM
A
A
-----
F
S
AGAT
F
VL
VEKY
SA
R
A
F
WG
Q
V
Q
K
Y
R
A
T
V
T
ECI
P
M
M
IR
T
L
M
V
Q
P
P
SAN
D
QQ
H
R
L
RE
V
M
F
Y
L
-
--
-N
LS
EQEK
DA
F
C
E
R
F
G
V
RLL
T
S
YGMTE
TIV
-
G
I
IG
---
-
D
R
P
GD
K
RRWP
S
I
GR
V
G
F
CY
-
---
E
AE
I
R
DD
HNR
PLP
A
GE
I
GE
ICI
KG
I
P
G
K
TI
F
K
E
YF
LN
PQ
A
TA
K
V
L
E
A
D
GW
L
H
T
GD
T
GYR
DEEG
FF
YFV
D
R
R
CN
M
I
K
RGGEN
V
S
CV
E
L
ENI
IA
A
HPKI
Q
D
I
V
VV
G
I
K
D
S
IR
D
E
A
IK
A
F
VVL
N
E
G
-
ET
LS
E
EE
F
F
RF
-C
EQ
N
M
AKFK
V
P
SY
L
E
IR
K
D
LPR
N
C
SGKI
I
R
K
N
L
fig|749548.3.peg.2384
Escherichia coli MS 196-1 (12-516/517)
M
W
D
D
--
LAD
VY
G
HK
TA
L
I
CE
S
S
GG
VV
N
--
-
-R
YSY
L
ELNQ
EI
N
R
T
AN
LFYTL
GI
R
K
GD
KV
A
L
H
L
D
N
CP
EF
IFC
W
F
G
L
A
KIGA
IM
VP
I
N
A
R
LL
R
E
E
S
T
W
I
L
QNS
QA
CLLVTS
A
QFYP
MYQ
QI
Q
-
--
--
---
Q
ED
A
S
QL
RH
I
CLT
D
MALP
A
D
DG
V
S
S
FT
QL
K
N
-
----------
Q
Q
PAT
LC
Y
A
P
P
LST
D
D
T
A
EI
LFTSGTT
S
R
PKG
G
VI
TH
Y
N
LRF
A
G
Y
Y
S
AWQ
C
A
L
R
D
D
DVYL
TVM
PA
F
H
IDCQCT
A
AM
A
A
-----
F
S
AGAT
F
VL
VEKY
SA
R
A
F
WG
Q
V
Q
K
Y
R
A
T
I
T
ECI
P
M
M
IR
T
L
M
V
Q
P
P
SAN
D
RQ
H
C
L
RE
V
M
F
Y
L
-
--
-N
LS
EQEK
DA
F
C
E
R
F
S
V
RLL
T
S
YGMTE
TIV
-
G
I
IG
---
-
D
R
P
GD
K
RRWP
S
I
GR
A
G
F
CY
-
---
E
AE
I
R
DD
HNR
PLP
A
GE
L
GE
ICI
KGVP
G
K
TI
F
K
E
YF
LN
P
K
A
TA
K
V
L
E
A
D
GW
L
H
T
GD
T
GYR
DEEG
FF
YFV
D
R
R
CN
M
I
K
RGGEN
V
S
CV
E
L
ENI
IA
A
HPKI
Q
D
I
V
VV
G
I
K
D
S
IR
D
E
A
IK
A
F
VVL
N
E
G
-
ET
LS
E
EE
F
F
RF
-C
EQ
N
M
AKFK
V
P
SY
L
E
IR
K
D
LPR
N
C
SGKI
I
R
K
N
L
fig|595496.3.peg.37
Escherichia coli BW2952 (12-516/517)
M
W
D
D
--
LAD
VY
G
HK
TA
L
I
CE
S
S
GG
VV
N
--
-
-R
YSY
L
ELNQ
EI
N
R
T
AN
LFYTL
GI
R
K
GD
KV
A
L
H
L
D
N
CP
EF
IFC
W
F
G
L
A
KIGA
IM
VP
I
N
A
R
LL
C
E
E
S
A
W
I
L
QNS
QA
CLLVTS
A
QFYP
MYQ
QI
Q
-
--
--
---
Q
ED
A
T
QL
RH
I
CLT
D
VALP
A
D
DG
V
S
S
FT
QL
K
N
-
----------
Q
Q
PAT
LC
Y
A
P
P
LST
D
D
T
A
EI
LFTSGTT
S
R
PKGV
VI
TH
Y
N
LRF
A
G
Y
Y
S
AWQ
C
A
L
R
D
D
DVYL
TVM
PA
F
H
IDCQCT
A
AM
A
A
-----
F
S
AGAT
F
VL
VEKY
SA
R
A
F
WG
Q
V
Q
K
Y
R
A
T
V
T
ECI
P
M
M
IR
T
L
M
V
Q
P
P
SAN
D
QQ
H
R
L
RE
V
M
F
Y
L
-
--
-N
LS
EQEK
DA
F
C
E
R
F
G
V
RLL
T
S
YGMTE
TIV
-
G
I
IG
---
-
D
R
P
GD
K
RRWP
S
I
GR
V
G
F
CY
-
---
E
AE
I
R
DD
HNR
PLP
A
GE
I
GE
ICI
KG
I
P
G
K
TI
F
K
E
YF
LN
PQ
A
TA
K
V
L
E
A
D
GW
L
H
T
GD
T
GYR
DEE
D
FF
YFV
D
R
R
CN
M
I
K
RGGEN
V
S
CV
E
L
ENI
IA
A
HPKI
Q
D
I
V
VV
G
I
K
D
S
IR
D
E
A
IK
A
F
VVL
N
E
G
-
ET
LS
E
EE
F
F
RF
-C
EQ
N
M
AKFK
V
P
SY
L
E
IR
K
D
LPR
N
C
SGKI
I
R
K
N
L
fig|536056.3.peg.3768
Escherichia coli DH1 (12-516/517)
M
W
D
D
--
LAD
VY
G
HK
TA
L
I
CE
S
S
GG
VV
N
--
-
-R
YSY
L
ELNQ
EI
N
R
T
AN
LFYTL
GI
R
K
GD
KV
A
L
H
L
D
N
CP
EF
IFC
W
F
G
L
A
KIGA
IM
VP
I
N
A
R
LL
C
E
E
S
A
W
I
L
QNS
QA
CLLVTS
A
QFYP
MYQ
QI
Q
-
--
--
---
Q
ED
A
T
QL
RH
I
CLT
D
VALP
A
D
DG
V
S
S
FT
QL
K
N
-
----------
Q
Q
PAT
LC
Y
A
P
P
LST
D
D
T
A
EI
LFTSGTT
S
R
PKGV
VI
TH
Y
N
LRF
A
G
Y
Y
S
AWQ
C
A
L
R
D
D
DVYL
TVM
PA
F
H
IDCQCT
A
AM
A
A
-----
F
S
AGAT
F
VL
VEKY
SA
R
A
F
WG
Q
V
Q
K
Y
R
A
T
V
T
ECI
P
M
M
IR
T
L
M
V
Q
P
P
SAN
D
QQ
H
R
L
RE
V
M
F
Y
L
-
--
-N
LS
EQEK
DA
F
C
E
R
F
G
V
RLL
T
S
YGMTE
TIV
-
G
I
IG
---
-
D
R
P
GD
K
RRWP
S
I
GR
V
G
F
CY
-
---
E
AE
I
R
DD
HNR
PLP
A
GE
I
GE
ICI
KG
I
P
G
K
TI
F
K
E
YF
LN
PQ
A
TA
K
V
L
E
A
D
GW
L
H
T
GD
T
GYR
DEE
D
FF
YFV
D
R
R
CN
M
I
K
RGGEN
V
S
CV
E
L
ENI
IA
A
HPKI
Q
D
I
V
VV
G
I
K
D
S
IR
D
E
A
IK
A
F
VVL
N
E
G
-
ET
LS
E
EE
F
F
RF
-C
EQ
N
M
AKFK
V
P
SY
L
E
IR
K
D
LPR
N
C
SGKI
I
R
K
N
L
fig|83333.1.peg.38
Escherichia coli K12 (12-516/517)
M
W
D
D
--
LAD
VY
G
HK
TA
L
I
CE
S
S
GG
VV
N
--
-
-R
YSY
L
ELNQ
EI
N
R
T
AN
LFYTL
GI
R
K
GD
KV
A
L
H
L
D
N
CP
EF
IFC
W
F
G
L
A
KIGA
IM
VP
I
N
A
R
LL
C
E
E
S
A
W
I
L
QNS
QA
CLLVTS
A
QFYP
MYQ
QI
Q
-
--
--
---
Q
ED
A
T
QL
RH
I
CLT
D
VALP
A
D
DG
V
S
S
FT
QL
K
N
-
----------
Q
Q
PAT
LC
Y
A
P
P
LST
D
D
T
A
EI
LFTSGTT
S
R
PKGV
VI
TH
Y
N
LRF
A
G
Y
Y
S
AWQ
C
A
L
R
D
D
DVYL
TVM
PA
F
H
IDCQCT
A
AM
A
A
-----
F
S
AGAT
F
VL
VEKY
SA
R
A
F
WG
Q
V
Q
K
Y
R
A
T
V
T
ECI
P
M
M
IR
T
L
M
V
Q
P
P
SAN
D
QQ
H
R
L
RE
V
M
F
Y
L
-
--
-N
LS
EQEK
DA
F
C
E
R
F
G
V
RLL
T
S
YGMTE
TIV
-
G
I
IG
---
-
D
R
P
GD
K
RRWP
S
I
GR
V
G
F
CY
-
---
E
AE
I
R
DD
HNR
PLP
A
GE
I
GE
ICI
KG
I
P
G
K
TI
F
K
E
YF
LN
PQ
A
TA
K
V
L
E
A
D
GW
L
H
T
GD
T
GYR
DEE
D
FF
YFV
D
R
R
CN
M
I
K
RGGEN
V
S
CV
E
L
ENI
IA
A
HPKI
Q
D
I
V
VV
G
I
K
D
S
IR
D
E
A
IK
A
F
VVL
N
E
G
-
ET
LS
E
EE
F
F
RF
-C
EQ
N
M
AKFK
V
P
SY
L
E
IR
K
D
LPR
N
C
SGKI
I
R
K
N
L
fig|316385.7.peg.37
Escherichia coli str. K-12 substr. DH10B (12-516/517)
M
W
D
D
--
LAD
VY
G
HK
TA
L
I
CE
S
S
GG
VV
N
--
-
-R
YSY
L
ELNQ
EI
N
R
T
AN
LFYTL
GI
R
K
GD
KV
A
L
H
L
D
N
CP
EF
IFC
W
F
G
L
A
KIGA
IM
VP
I
N
A
R
LL
C
E
E
S
A
W
I
L
QNS
QA
CLLVTS
A
QFYP
MYQ
QI
Q
-
--
--
---
Q
ED
A
T
QL
RH
I
CLT
D
VALP
A
D
DG
V
S
S
FT
QL
K
N
-
----------
Q
Q
PAT
LC
Y
A
P
P
LST
D
D
T
A
EI
LFTSGTT
S
R
PKGV
VI
TH
Y
N
LRF
A
G
Y
Y
S
AWQ
C
A
L
R
D
D
DVYL
TVM
PA
F
H
IDCQCT
A
AM
A
A
-----
F
S
AGAT
F
VL
VEKY
SA
R
A
F
WG
Q
V
Q
K
Y
R
A
T
V
T
ECI
P
M
M
IR
T
L
M
V
Q
P
P
SAN
D
QQ
H
R
L
RE
V
M
F
Y
L
-
--
-N
LS
EQEK
DA
F
C
E
R
F
G
V
RLL
T
S
YGMTE
TIV
-
G
I
IG
---
-
D
R
P
GD
K
RRWP
S
I
GR
V
G
F
CY
-
---
E
AE
I
R
DD
HNR
PLP
A
GE
I
GE
ICI
KG
I
P
G
K
TI
F
K
E
YF
LN
PQ
A
TA
K
V
L
E
A
D
GW
L
H
T
GD
T
GYR
DEE
D
FF
YFV
D
R
R
CN
M
I
K
RGGEN
V
S
CV
E
L
ENI
IA
A
HPKI
Q
D
I
V
VV
G
I
K
D
S
IR
D
E
A
IK
A
F
VVL
N
E
G
-
ET
LS
E
EE
F
F
RF
-C
EQ
N
M
AKFK
V
P
SY
L
E
IR
K
D
LPR
N
C
SGKI
I
R
K
N
L
fig|511145.12.peg.36
Escherichia coli str. K-12 substr. MG1655 (12-516/517)
M
W
D
D
--
LAD
VY
G
HK
TA
L
I
CE
S
S
GG
VV
N
--
-
-R
YSY
L
ELNQ
EI
N
R
T
AN
LFYTL
GI
R
K
GD
KV
A
L
H
L
D
N
CP
EF
IFC
W
F
G
L
A
KIGA
IM
VP
I
N
A
R
LL
C
E
E
S
A
W
I
L
QNS
QA
CLLVTS
A
QFYP
MYQ
QI
Q
-
--
--
---
Q
ED
A
T
QL
RH
I
CLT
D
VALP
A
D
DG
V
S
S
FT
QL
K
N
-
----------
Q
Q
PAT
LC
Y
A
P
P
LST
D
D
T
A
EI
LFTSGTT
S
R
PKGV
VI
TH
Y
N
LRF
A
G
Y
Y
S
AWQ
C
A
L
R
D
D
DVYL
TVM
PA
F
H
IDCQCT
A
AM
A
A
-----
F
S
AGAT
F
VL
VEKY
SA
R
A
F
WG
Q
V
Q
K
Y
R
A
T
V
T
ECI
P
M
M
IR
T
L
M
V
Q
P
P
SAN
D
QQ
H
R
L
RE
V
M
F
Y
L
-
--
-N
LS
EQEK
DA
F
C
E
R
F
G
V
RLL
T
S
YGMTE
TIV
-
G
I
IG
---
-
D
R
P
GD
K
RRWP
S
I
GR
V
G
F
CY
-
---
E
AE
I
R
DD
HNR
PLP
A
GE
I
GE
ICI
KG
I
P
G
K
TI
F
K
E
YF
LN
PQ
A
TA
K
V
L
E
A
D
GW
L
H
T
GD
T
GYR
DEE
D
FF
YFV
D
R
R
CN
M
I
K
RGGEN
V
S
CV
E
L
ENI
IA
A
HPKI
Q
D
I
V
VV
G
I
K
D
S
IR
D
E
A
IK
A
F
VVL
N
E
G
-
ET
LS
E
EE
F
F
RF
-C
EQ
N
M
AKFK
V
P
SY
L
E
IR
K
D
LPR
N
C
SGKI
I
R
K
N
L
fig|511145.6.peg.37
Escherichia coli str. K-12 substr. MG1655 (12-516/517)
M
W
D
D
--
LAD
VY
G
HK
TA
L
I
CE
S
S
GG
VV
N
--
-
-R
YSY
L
ELNQ
EI
N
R
T
AN
LFYTL
GI
R
K
GD
KV
A
L
H
L
D
N
CP
EF
IFC
W
F
G
L
A
KIGA
IM
VP
I
N
A
R
LL
C
E
E
S
A
W
I
L
QNS
QA
CLLVTS
A
QFYP
MYQ
QI
Q
-
--
--
---
Q
ED
A
T
QL
RH
I
CLT
D
VALP
A
D
DG
V
S
S
FT
QL
K
N
-
----------
Q
Q
PAT
LC
Y
A
P
P
LST
D
D
T
A
EI
LFTSGTT
S
R
PKGV
VI
TH
Y
N
LRF
A
G
Y
Y
S
AWQ
C
A
L
R
D
D
DVYL
TVM
PA
F
H
IDCQCT
A
AM
A
A
-----
F
S
AGAT
F
VL
VEKY
SA
R
A
F
WG
Q
V
Q
K
Y
R
A
T
V
T
ECI
P
M
M
IR
T
L
M
V
Q
P
P
SAN
D
QQ
H
R
L
RE
V
M
F
Y
L
-
--
-N
LS
EQEK
DA
F
C
E
R
F
G
V
RLL
T
S
YGMTE
TIV
-
G
I
IG
---
-
D
R
P
GD
K
RRWP
S
I
GR
V
G
F
CY
-
---
E
AE
I
R
DD
HNR
PLP
A
GE
I
GE
ICI
KG
I
P
G
K
TI
F
K
E
YF
LN
PQ
A
TA
K
V
L
E
A
D
GW
L
H
T
GD
T
GYR
DEE
D
FF
YFV
D
R
R
CN
M
I
K
RGGEN
V
S
CV
E
L
ENI
IA
A
HPKI
Q
D
I
V
VV
G
I
K
D
S
IR
D
E
A
IK
A
F
VVL
N
E
G
-
ET
LS
E
EE
F
F
RF
-C
EQ
N
M
AKFK
V
P
SY
L
E
IR
K
D
LPR
N
C
SGKI
I
R
K
N
L
fig|316407.3.peg.37
Escherichia coli W3110 (17-521/522)
M
W
D
D
--
LAD
VY
G
HK
TA
L
I
CE
S
S
GG
VV
N
--
-
-R
YSY
L
ELNQ
EI
N
R
T
AN
LFYTL
GI
R
K
GD
KV
A
L
H
L
D
N
CP
EF
IFC
W
F
G
L
A
KIGA
IM
VP
I
N
A
R
LL
C
E
E
S
A
W
I
L
QNS
QA
CLLVTS
A
QFYP
MYQ
QI
Q
-
--
--
---
Q
ED
A
T
QL
RH
I
CLT
D
VALP
A
D
DG
V
S
S
FT
QL
K
N
-
----------
Q
Q
PAT
LC
Y
A
P
P
LST
D
D
T
A
EI
LFTSGTT
S
R
PKGV
VI
TH
Y
N
LRF
A
G
Y
Y
S
AWQ
C
A
L
R
D
D
DVYL
TVM
PA
F
H
IDCQCT
A
AM
A
A
-----
F
S
AGAT
F
VL
VEKY
SA
R
A
F
WG
Q
V
Q
K
Y
R
A
T
V
T
ECI
P
M
M
IR
T
L
M
V
Q
P
P
SAN
D
QQ
H
R
L
RE
V
M
F
Y
L
-
--
-N
LS
EQEK
DA
F
C
E
R
F
G
V
RLL
T
S
YGMTE
TIV
-
G
I
IG
---
-
D
R
P
GD
K
RRWP
S
I
GR
V
G
F
CY
-
---
E
AE
I
R
DD
HNR
PLP
A
GE
I
GE
ICI
KG
I
P
G
K
TI
F
K
E
YF
LN
PQ
A
TA
K
V
L
E
A
D
GW
L
H
T
GD
T
GYR
DEE
D
FF
YFV
D
R
R
CN
M
I
K
RGGEN
V
S
CV
E
L
ENI
IA
A
HPKI
Q
D
I
V
VV
G
I
K
D
S
IR
D
E
A
IK
A
F
VVL
N
E
G
-
ET
LS
E
EE
F
F
RF
-C
EQ
N
M
AKFK
V
P
SY
L
E
IR
K
D
LPR
N
C
SGKI
I
R
K
N
L
fig|316385.5.peg.38
Escherichia coli str. K-12 substr. DH10B (17-521/522)
M
W
D
D
--
LAD
VY
G
HK
TA
L
I
CE
S
S
GG
VV
N
--
-
-R
YSY
L
ELNQ
EI
N
R
T
AN
LFYTL
GI
R
K
GD
KV
A
L
H
L
D
N
CP
EF
IFC
W
F
G
L
A
KIGA
IM
VP
I
N
A
R
LL
C
E
E
S
A
W
I
L
QNS
QA
CLLVTS
A
QFYP
MYQ
QI
Q
-
--
--
---
Q
ED
A
T
QL
RH
I
CLT
D
VALP
A
D
DG
V
S
S
FT
QL
K
N
-
----------
Q
Q
PAT
LC
Y
A
P
P
LST
D
D
T
A
EI
LFTSGTT
S
R
PKGV
VI
TH
Y
N
LRF
A
G
Y
Y
S
AWQ
C
A
L
R
D
D
DVYL
TVM
PA
F
H
IDCQCT
A
AM
A
A
-----
F
S
AGAT
F
VL
VEKY
SA
R
A
F
WG
Q
V
Q
K
Y
R
A
T
V
T
ECI
P
M
M
IR
T
L
M
V
Q
P
P
SAN
D
QQ
H
R
L
RE
V
M
F
Y
L
-
--
-N
LS
EQEK
DA
F
C
E
R
F
G
V
RLL
T
S
YGMTE
TIV
-
G
I
IG
---
-
D
R
P
GD
K
RRWP
S
I
GR
V
G
F
CY
-
---
E
AE
I
R
DD
HNR
PLP
A
GE
I
GE
ICI
KG
I
P
G
K
TI
F
K
E
YF
LN
PQ
A
TA
K
V
L
E
A
D
GW
L
H
T
GD
T
GYR
DEE
D
FF
YFV
D
R
R
CN
M
I
K
RGGEN
V
S
CV
E
L
ENI
IA
A
HPKI
Q
D
I
V
VV
G
I
K
D
S
IR
D
E
A
IK
A
F
VVL
N
E
G
-
ET
LS
E
EE
F
F
RF
-C
EQ
N
M
AKFK
V
P
SY
L
E
IR
K
D
LPR
N
C
SGKI
I
R
K
N
L
fig|749544.3.peg.2653
Escherichia coli MS 175-1 (1-505/506)
M
W
D
D
--
LAD
VY
G
HK
TA
L
I
CE
S
S
GG
VV
N
--
-
-R
YSY
L
ELNQ
EI
N
R
T
AN
LFYTL
GI
R
K
GD
KV
A
L
H
L
D
N
CP
EF
IFC
W
F
G
L
A
KIGA
IM
VP
I
N
A
R
LL
R
E
E
S
T
W
I
L
QNS
QA
CLLVTS
A
QFYP
MYQ
QI
Q
-
--
--
---
Q
ED
A
S
QL
RH
I
CLT
D
MALP
A
D
DG
V
S
S
FT
QL
K
N
-
----------
Q
Q
PAT
LC
Y
A
P
P
LST
D
D
T
A
EI
LFTSGTT
S
R
S
KGV
VI
TH
Y
N
LRF
A
G
Y
Y
S
AWQ
C
A
L
R
D
D
DVYL
TVM
PA
F
H
IDCQCT
A
AM
A
A
-----
F
S
AGAT
F
VL
VEKY
SA
R
A
F
WG
Q
V
Q
K
Y
R
A
T
I
T
ECI
P
M
M
IR
T
L
M
V
Q
P
P
SAN
D
RQ
H
C
L
RE
V
M
F
Y
L
-
--
-N
LS
EQEK
DA
F
C
E
C
F
S
V
RLL
T
S
YGMTE
TIV
-
G
I
IG
---
-
D
R
P
GD
K
RRWP
S
I
GR
A
G
F
CY
-
---
E
AE
I
R
DD
HNR
PLP
A
GE
L
GE
ICI
KGVP
G
K
TI
F
K
E
YF
LN
P
K
A
TA
K
V
L
E
A
D
GW
L
H
T
GD
T
GYR
DEEG
FF
YFV
D
R
R
CN
M
I
K
RGGEN
V
S
CV
E
L
ENI
IA
A
HPKI
Q
D
I
V
VV
G
I
K
D
S
IR
D
E
A
IK
A
F
VVL
N
E
G
-
ET
LS
E
EE
F
F
RF
-C
EQ
N
M
AKFK
V
P
SY
L
E
IR
K
D
LPR
N
C
SGKI
I
R
K
N
L
fig|749538.3.peg.2043
Escherichia coli MS 116-1 (1-505/506)
M
W
D
D
--
LAD
VY
G
HK
TA
L
I
CE
S
S
GG
VV
N
--
-
-R
YSY
L
ELNQ
EI
N
R
T
AN
LFYTL
GI
R
K
GD
KV
A
L
H
L
D
N
CP
EF
IFC
W
F
G
L
A
KIGA
IM
VP
I
N
A
R
LL
R
E
E
S
T
W
I
L
QNS
QA
CLLVTS
A
QFYP
MYQ
QI
Q
-
--
--
---
Q
ED
A
S
QL
RH
I
CLT
D
MALP
A
D
DG
V
S
S
FT
QL
K
N
-
----------
Q
H
P
P
T
LC
Y
A
P
P
LST
D
D
T
A
EI
LFTSGTT
S
R
S
KGV
VI
TH
Y
N
LRF
A
G
Y
Y
S
AWQ
C
A
L
R
D
D
DVYL
TVM
PA
F
H
IDCQCT
A
AM
A
A
-----
F
S
AGAT
F
VL
VEKY
SA
R
A
F
WG
Q
V
Q
K
Y
R
A
T
I
T
ECI
P
M
M
IR
T
L
M
V
Q
P
P
SAN
D
RQ
H
C
L
RE
V
M
F
Y
L
-
--
-N
LS
EQEK
DA
F
C
E
C
F
S
V
RLL
T
S
YGMTE
TIV
-
G
I
IG
---
-
D
R
P
GD
K
RRWP
S
I
GR
A
G
F
CY
-
---
E
AE
I
R
DD
HNR
PLP
A
GE
L
GE
ICI
KGVP
G
K
TI
F
K
E
YF
LN
P
K
A
TA
K
V
L
E
A
D
GW
L
H
T
GD
T
GYR
DEEG
FF
YFV
D
R
R
CN
M
I
K
RGGEN
V
S
CV
E
L
ENI
IA
A
HPKI
Q
D
I
V
VV
G
I
K
D
S
IR
D
E
A
IK
A
F
VVL
N
E
G
-
ET
LS
E
EE
F
F
RF
-C
EQ
N
M
AKFK
V
P
SY
L
E
IR
K
D
LPR
N
C
SGKI
I
R
K
N
L
Consen1
Primary consensus
MKVTLTFNEQRRAAYRekG
W
D
LaD
-
Ta
a
dsiaVvd
-
ysY
eLnqaad
lAn
GIk
Gd
a
qL
n
Ef
ffallKiGa
Vp
l
s
r
El
w
l
qa
a
----
Qiep
li
Q
l
ql
i
d
a
ssi
-
s
Ql
nd
----------
n
Pat
tA
p
De
A
lftsGTtg
PKgv
THnn
s
r
s
c
lt
qdvyl
Pa
H
a
ap
-----
FlaGat
VL
sa
ac
liek
r
t
t
pp
v
-
l
lq
l
e
a
L
l
f
l
gg
ls
ar
c
e
G
rLl
vyGmtE
-
glvn
---
lDdp
k
----
iht
Gy
-
E
v
Dd
pLP
Ge
Ge
r
---
Gp
F
gYf
Pq
tA
aldanGwy
sGDl
DeeGyi
gRekd
I
RGGEnis
EiEnill
HPki
da
vV
m
De
gE
scAyvVlkep
-
Ls
eev
rF
eq
iAkfK
P
ve
d
LPrt
sGKi
kk
LRqwlasRltQDvCEEIE
Consen2
Secondary consensus
qq
t
g
r
i
skgg
in
g
lt
a
dhei
t
c
e
l
h
g
l
lgca
l
v
l
n
r
e
s
-
-
--
tqfyp
t
-
--
a
sg
f
n
e
dg
sr
i
a
-
sgehnlqdaiq
le
y
t
d
qlsg
es
li
yd
a
y
y
l
fr
dtrfm
l
g
sagslgv
si
gr
tp
lf
q
qq
q
n
m
tm
ir
d
vn
p
h
v
l
q
--
ip
da
p
q
sf
sa
ha
igytr
-
rs
rrrwp
mgr
f
c
i
a
t
c
r
kgvp
k
e
y
n
vfee
fl
t
t
pa
ff
d
cn
kva
dlia
av
yi
l
i
s
d
ik
fl
vnagh
r
vqf
a
rk
ey
v
ln
v
v
rf
kdimr
ts
a
Consensus 1
(when a gap)
Conservative difference
Consensus 2
(when a gap)
Nonconservative diff.
Other character