┌─ Escherichia coli (7-322/332) ED1a (2)  
                                                                       ┌┴─ Escherichia coli (7-322/332) APEC O1 (5)  
                                                                      ┌┴─ Escherichia coli (7-322/332) 83972 (9)  
                                                                     ┌┴─ Escherichia coli (7-322/332) MS 145-7   
                                                                    ┌┴┬─ Escherichia coli (7-322/332) B7A (1)  
                                                                    │ └┬─ Escherichia coli (7-322/332) M718   
                                                                   ┌┤  └┬─ Escherichia coli (7-322/332) F11 (2)  
                                                                   ││   └─ Escherichia coli (7-322/332) 536 (1)  
                                                ┌──────────────────┤└┬─ Escherichia coli (7-322/332) MS 124-1 (1)  
                                                │                  │ └─ Escherichia coli (7-322/332) K12 (29)  
                                      ┌─────────┤                  └─ Escherichia coli (7-322/332) MS 196-1   
                                      │         │          ┌─ Escherichia coli (8-321/331) 101-1 (7)  
                                      │         └──────────┤ ┌─ Escherichia coli (8-321/331) APEC O1 (6)  
                                      │                    └┬┴─ Escherichia coli (8-321/331) M718   
                                      │                     └┬─ Escherichia coli (8-321/331) 042 (53)  
                                      │                      └┬─ Escherichia coli (8-321/331) MS 185-1   
                        ┌─────────────┤                       └┬─ Escherichia coli (8-321/331) MS 21-1   
                        │             │                        └┬─ fig|1040638.4.peg.2021 O104:H4 (8-321/331) str. LB226692 (13)  
                        │             │                         └┬─ Escherichia coli (8-321/331) 1044A (41)  
                        │             │                          └┬─ Escherichia coli (1-311/321) O157:H7 EDL933 (1)  
                ┌───────┤             │                           └─ Escherichia coli (1-311/321) str. K-12 substr. DH10B   
                │       │             └──────────────────────── Escherichia coli (14-338/339) H299 (1)  
                │       │                             ┌─ Escherichia coli (8-339/342) M718   
                │       │                             │┌─ Escherichia coli (8-339/342) B354 (2)  
                │       └─────────────────────────────┤│     ┌─ Escherichia coli (8-342/342) 83972 (5)  
                │                                     ││    ┌┴─ Escherichia coli (8-342/342) APEC O1 (6)  
                │                                     ││   ┌┴─ Escherichia coli (8-342/342) ED1a (1)  
                │                                     └┤  ┌┴─ Escherichia coli (8-339/342) NC101 (2)  
                │                                      │ ┌┴─ Escherichia coli (8-339/342) M605 (1)  
                │                                      │┌┴┬─ Escherichia coli (8-339/342) 536 (4)  
                │                                      ││ └─ Escherichia coli (8-339/342) E110019 (1)  
                │                                      └┤ ┌─ Escherichia coli (8-339/342) 1125A (12)  
                │                                       │┌┴─ Escherichia coli (8-339/342) MS 21-1   
                │                                       └┤┌─ fig|1040638.4.peg.3669 O104:H4 (8-339/342) str. LB226692 (53)  
                │                                        └┤ ┌─ Escherichia coli (8-339/342) K12 (20)  
                │                                         └┬┴─ Escherichia coli (8-339/342) MS 115-1   
             ┌──┤                                          └┬─ Escherichia coli (8-339/342) 101-1 (5)  
             │  │                                           └┬─ Escherichia coli (1-322/325) 1827-70   
             │  │                                            └─ Escherichia coli (1-322/325) FVEC1412 (1)  
             │  │                                    ┌─ Escherichia coli (1-330/343) 2362-75 (27)  
             │  │                                   ┌┴─ Escherichia coli (1-330/343) TA206   
             │  │                                  ┌┴─ Escherichia coli (1-330/343) NC101   
             │  │                                 ┌┴─ Escherichia coli (1-330/343) MS 21-1   
             │  │                                ┌┴─ Escherichia coli (1-330/343) B185 (4)  
             │  │                               ┌┴┬─ Escherichia coli (1-330/343) 1044A (24)  
             │  │                              ┌┤ └─ Escherichia coli (1-330/343) K12 (20)  
             │  │                             ┌┤└─ Escherichia coli (1-330/343) 53638 (1)  
             │  │                             │└┬─ fig|1040638.4.peg.2734 O104:H4 (1-330/343) str. LB226692 (36)  
             │  │                 ┌───────────┤ └┬─ Escherichia coli (1-330/343) MS 124-1 (1)  
             │  │                 │           │  └─ Escherichia coli (1-330/343) IAI1 (4)  
             │  │                 │           └─ Escherichia coli (1-330/343) MS 115-1   
             │  └─────────────────┤         ┌─ Escherichia coli (1-330/346) O111:H- str. 11128   
          ┌──┤                    │         │    ┌─ Escherichia coli (1-330/346) 2362-75 (25)  
          │  │                    │         │   ┌┴─ Escherichia coli (1-330/346) NC101   
          │  │                    └─────────┤  ┌┴─ Escherichia coli (3-332/348) E2348/69   
          │  │                              │ ┌┴─ Escherichia coli (1-330/346) 1044A (25)  
          │  │                              │┌┴┬─ fig|1040638.4.peg.3225 O104:H4 (1-330/346) str. LB226692 (3)  
          │  │                              ││ └┬─ Escherichia coli (1-330/346) 101-1   
          │  │                              └┤  └─ Escherichia coli (1-330/346) B str. REL606 (3)  
          │  │                               │┌─ Escherichia coli (3-332/348) 042 (36)  
          │  │                               └┤  ┌─ Escherichia coli (1-330/346) M718   
      ┌───┤  │                                │ ┌┴─ Escherichia coli (1-330/346) 53638 (1)  
      │   │  │                                └┬┴─ Escherichia coli (1-330/346) K12 (12)  
      │   │  │                                 └┬─ Escherichia coli (1-330/346) IAI39 (1)  
      │   │  │                                  └┬─ Escherichia coli (1-330/346) B7A (6)  
      │   │  │                                   └┬─ Escherichia coli (1-330/346) B171 (4)  
      │   │  │                                    └─ Escherichia coli (1-330/346) B185   
      │   │  └───────────────────────────────────────┬─ Escherichia coli (2-327/336) M718 (3)  
    ┌─┤   │                                          └────┬─ Escherichia coli (2-323/336) E24377A (1)  
    │ │   │                                               └─ Escherichia coli (2-323/336) SMS-3-5   
    │ │   └──────────────────┬───────────────── Escherichia coli (5-328/360) H299   
    │ │                      └──────────────┬─ Escherichia coli (6-329/356) H736   
    │ │                                     └─ Escherichia coli (6-329/356) MS 116-1   
    │ │                     ┌──────────────────────────── Escherichia coli (4-328/332) 101-1 (5)  
    │ └─────────────────────┤                            ┌─ Escherichia coli (8-333/335) 2362-75 (12)  
    │                       │                           ┌┴─ Escherichia coli (8-333/335) MS 124-1 (1)  
    │                       └─────┬─────────────────────┴─ Escherichia coli (8-333/335) IAI39 (1)  
    │                             └───────────────────────┬─ Escherichia coli (3-330/334) DH1   
    │                                                     └┬─ Escherichia coli (3-330/334) K12 (125)  
 ┌──┤                                                      └┬─ Escherichia coli (3-330/334) 1125A (1)  
 │  │                                                       └─ Escherichia coli (3-330/334) FVEC1412 (1)  
 │  │                            ┌─ Escherichia coli 042 (20)  
 │  │                           ┌┴─ Escherichia coli B088   
 │  │                          ┌┴─ Escherichia coli APEC O1 (8)  
 │  │                         ┌┴─ Escherichia coli 83972 (1)  
 │  │                        ┌┴─ Escherichia coli ABU 83972 (3)  
 │  │                       ┌┴─ Escherichia coli 2362-75 (13)  
 │  │                      ┌┴─ Escherichia coli K12 (75)  
 │  │       ┌──────────────┴─ Escherichia coli E24377A (1)  
 │  │       │               ┌─ Escherichia coli (1-326/327) H591 (2)  
 │  └───────┤              ┌┴─ Escherichia coli (1-326/327) E24377A (6)  
 │          │             ┌┴─ Escherichia coli (1-329/330) E24377A   
 │          └─────────────┤ ┌─ Escherichia coli (1-329/330) K12 (12)  
 │                        │┌┴─ Escherichia coli (1-329/330) APEC O1  [2] 
 │                        └┤┌─ Escherichia coli (1-329/330) ATCC 8739  [2] 
┌┤                         └┤ ┌─ Escherichia coli (1-326/327) M605 (1)  
││                          └┬┴─ Escherichia coli (1-326/327) B354   
││                           └┬─ Escherichia coli (1-326/327) B str. REL606 (2)  
││                            └┬─ fig|1040638.4.peg.1465 O104:H4 (1-326/327) str. LB226692 (78)  
││                             └┬─ Escherichia coli (1-326/327) 2362-75   
││                              └─ Escherichia coli (1-326/327) 1212A (1)  
││                                 ┌─ Escherichia coli (4-325/332) M605   
││                                ┌┴─ Escherichia coli (4-325/332) SE15   
││                               ┌┴┬─ Escherichia coli (4-325/332) NC101   
││                              ┌┤ └─ Escherichia coli (4-325/332) 2362-75 (14)  
││                              │└┬─ Escherichia coli (4-325/332) APEC O1 (6)  
││                             ┌┤ └─ Escherichia coli (4-325/332) WV_060327   
││                             │└┬─ Escherichia coli (4-325/332) MS 21-1   
││                            ┌┤ └─ Escherichia coli (4-325/332) SMS-3-5   
││                            │└─ Escherichia coli (4-325/332) ED1a (2)  
│└────────────────────────────┤ ┌─ Escherichia coli (4-325/332) 1044A (24)  
┤                             │┌┴─ Escherichia coli (4-325/332) O55:H7 str. CB9615   
│                             ││   ┌─ Escherichia coli (4-325/332) H299   
│                             └┤  ┌┴─ Escherichia coli (4-325/332) IAI39 (1)  
│                              │ ┌┴─ Escherichia coli (4-325/332) TA280   
│                              │┌┴┬─ Escherichia coli (4-329/332) M718   
│                              └┤ └─ Escherichia coli (4-325/332) MS 69-1   
│                               │ ┌─ Escherichia coli (4-325/332) MS 196-1   
│                               └┬┴─ Escherichia coli (4-325/332) K12 (25)  
│                                └┬─ fig|1040638.4.peg.4084 O104:H4 (4-325/332) str. LB226692 (5)  
│                                 └┬─ Escherichia coli (4-325/332) E110019 (1)  
│                                  └┬─ Escherichia coli (4-325/332) O111:H- str. 11128   
│                                   └─ Escherichia coli (4-325/332) B088 (23)  
│                                                  ┌─ Escherichia coli (7-337/367) FVEC1302 (3)  
│                                                 ┌┴─ Escherichia coli (30-360/390) MS 69-1   
│                                              ┌──┴─ Escherichia coli (30-360/390) MS 21-1   
│   ┌──────────────────────────────────────────┴──── Escherichia coli (7-337/356) 101-1 (8)  
└───┤                                        ┌─ Escherichia coli (1-320/327) TA271   
    └────────────────────────────────────────┤┌─ Escherichia coli (1-320/327) MS 124-1 (1)  
                                             └┤┌─ fig|1040638.4.peg.2229 O104:H4 (1-320/327) str. LB226692 (20)  
                                              ││┌─ Escherichia coli (1-320/327) B171 (1)  
                                              └┤│   ┌─ Escherichia coli (13-332/339) 1827-70 (6)  
                                               ││  ┌┴─ Escherichia coli (1-320/327) O111:H- str. 11128   
                                               └┤ ┌┴─ Escherichia coli (1-320/327) K12 (22)  
                                                │┌┴─ Escherichia coli (1-320/327) 53638 (1)  
                                                ││  ┌─ Escherichia coli (1-320/327) 042 (6)  
                                                └┤ ┌┴─ Escherichia coli (1-320/327) MS 69-1   
                                                 │┌┴─ Escherichia coli (1-320/327) B185   
                                                 └┤ ┌─ Escherichia coli (1-320/327) O157:H7 EDL933  [2] 
                                                  │┌┴─ Escherichia coli (1-320/327) M718   
                                                  └┤┌─ Escherichia coli (1-320/327) 1044A (23)  
                                                   └┤ ┌─ Escherichia coli (1-320/327) MS 115-1   
                                                    │┌┴─ Escherichia coli (1-320/327) B354   
                                                    └┤┌─ Escherichia coli (1-320/327) TA280   
                                                     └┤┌─ Escherichia coli (1-320/327) 536 (1)  
                                                      └┤┌─ Escherichia coli (1-320/327) NC101   
                                                       └┤ ┌─ Escherichia coli (1-320/327) F11 (3)  
                                                        └┬┴─ Escherichia coli (1-320/327) H299   
                                                         └┬─ Escherichia coli (1-320/327) O83:H1 str. NRG 857C   
                                                          └┬─ Escherichia coli (1-320/327) 83972 (5)  
                                                           └┬─ Escherichia coli (1-320/327) 2362-75 (2)  
                                                            └┬─ Escherichia coli (1-320/327) APEC O1 (9)  
                                                             └─ Escherichia coli (1-320/327) ED1a (2)  
  
Evolved beta-D-galactosidase transcriptional repressor (25)
Transcriptional regulator YcjW, LacI family, possibly involved in maltodextrin utilization pathway (20)
Maltose regulon regulatory protein MalI (repressor for malXY) (16)
Mgl repressor and galactose ultrainduction factor GalS, HTH-type transcriptional regulator (15)
Galactose operon repressor, GalR-LacI family of transcriptional regulators (11)
Positive regulator of L-idonate catabolism (11)
Ribose operon repressor (11)
Gluconate utilization system Gnt-I transcriptional repressor (9)
Purine nucleotide synthesis repressor (8)
Transcriptional regulator, LacI family (5)
Fructose repressor FruR, LacI family (5)
Transcriptional repressor of the lac operon (3)
Sucrose operon repressor ScrR, LacI family (3)
Putative ThuR, regulatory protein for trehalosemaltose transport (3)
hypothetical transcriptional regulator YcjW (1)
Others (7)