fig|1040638.4.peg.3713
Escherichia coli O104:H4 str. LB226692
MKINYP
L
LALA
I
GAFG
I
GTTEF
S
PMGLL
PV
IA
RG
V
D
VSIPAAG
M
L
IS
A
YA
V
GV
M
VGAP
LMT
L
LL
S
HRA
RR
SA
LIFL
M
A
I
F
TL
GNVLS
A
IA
P
D
Y
MT
L
M
L
SRI
LTS
L
N
HGAFFGLG
S
V
VA
AS
V
V
P
K
H
K
Q
A
S
AVA
T
M
FM
G
L
TLAN
I
G
GVP
AA
T
W
LG
E
T
I
GWRM
S
FLA
T
A
GLG
VI
S
M
V
SL
FFS
LP
KGGA
G
A
R
P
E
V
-
K
KELAV
L
M
RP
Q
VL
S
A
L
L
T
TV
L
G
AG
A
M
FT
L
Y
T
YI
S
P
V
LQ
S
IT
H
A
T
PV
F
V
TA
M
L
V
LIG
V
G
FS
IGN
Y
L
G
GKL
AD
R
S
VN---G
T
LKG
FLL
L
L
MV
I
ML
A
IP
F
L
A
RN
E
FGAA
I
S
---
MVV
WGAA
T
FAV
VP
PLQM
R
V
M
RV
A
SE
A
PG
L
SS
S
VNI
GAFNLG
N
A
L
GA
AA
GG
A
V
I
S
-
A
GL
G
YS
F
V
PVM
GAI
V-
-
A
G
L
A
-
L
LLVF
M
S
ARK
QPETVCVANS
fig|6666666.5357.peg.1863
Escherichia coli TY-2482
MKINYP
L
LALA
I
GAFG
I
GTTEF
S
PMGLL
PV
IA
RG
V
D
VSIPAAG
M
L
IS
A
YA
V
GV
M
VGAP
LMT
L
LL
S
HRA
RR
SA
LIFL
M
A
I
F
TL
GNVLS
A
IA
P
D
Y
MT
L
M
L
SRI
LTS
L
N
HGAFFGLG
S
V
VA
AS
V
V
P
K
H
K
Q
A
S
AVA
T
M
FM
G
L
TLAN
I
G
GVP
AA
T
W
LG
E
T
I
GWRM
S
FLA
T
A
GLG
VI
S
M
V
SL
FFS
LP
KGGA
G
A
R
P
E
V
-
K
KELAV
L
M
RP
Q
VL
S
A
L
L
T
TV
L
G
AG
A
M
FT
L
Y
T
YI
S
P
V
LQ
S
IT
H
A
T
PV
F
V
TA
M
L
V
LIG
V
G
FS
IGN
Y
L
G
GKL
AD
R
S
VN---G
T
LKG
FLL
L
L
MV
I
ML
A
IP
F
L
A
RN
E
FGAA
I
S
---
MVV
WGAA
T
FAV
VP
PLQM
R
V
M
RV
A
SE
A
PG
L
SS
S
VNI
GAFNLG
N
A
L
GA
AA
GG
A
V
I
S
-
A
GL
G
YS
F
V
PVM
GAI
V-
-
A
G
L
A
-
L
LLVF
M
S
ARK
QPETVCVANS
fig|216592.1.peg.1186
Escherichia coli 042
MKINYP
L
LALA
I
GAFG
I
GTTEF
S
PMGLL
PV
IA
RG
V
D
VSIPAAG
M
L
IS
A
YA
V
GV
M
VGAP
LMT
L
LL
S
HRA
RR
SA
LIFL
M
A
I
F
TL
GNVLS
A
IA
P
D
Y
MT
L
M
L
SRI
LTS
L
N
HGAFFGLG
S
V
VA
AS
V
V
P
K
H
K
Q
A
S
AVA
T
M
FM
G
L
TLAN
I
G
GVP
AA
T
W
LG
E
T
I
GWRM
S
FLA
T
A
GLG
VI
S
M
V
SL
FFS
LP
KGGA
G
A
R
P
E
V
-
K
KELAV
L
M
RP
Q
VL
S
A
L
L
T
TV
L
G
AG
A
M
FT
L
Y
T
YI
S
P
V
LQ
S
IT
H
A
T
PV
F
V
TA
M
L
V
LIG
V
G
FS
IGN
Y
L
G
GKL
AD
R
S
VN---G
T
LKG
FLL
L
L
MV
I
ML
A
IP
F
L
A
RN
E
FGAA
I
S
---
MVV
WGAA
T
FAV
VP
PLQM
R
V
M
RV
A
SE
A
PG
L
SS
S
VNI
GAFNLG
N
A
L
GA
AA
GG
A
V
I
S
-
A
GL
G
YS
F
V
PVM
GAI
V-
-
A
G
L
A
-
L
LLVF
M
S
ARK
QPETVCVANS
fig|216592.3.peg.1898
Escherichia coli 042
MKINYP
L
LALA
I
GAFG
I
GTTEF
S
PMGLL
PV
IA
RG
V
D
VSIPAAG
M
L
IS
A
YA
V
GV
M
VGAP
LMT
L
LL
S
HRA
RR
SA
LIFL
M
A
I
F
TL
GNVLS
A
IA
P
D
Y
MT
L
M
L
SRI
LTS
L
N
HGAFFGLG
S
V
VA
AS
V
V
P
K
H
K
Q
A
S
AVA
T
M
FM
G
L
TLAN
I
G
GVP
AA
T
W
LG
E
T
I
GWRM
S
FLA
T
A
GLG
VI
S
M
V
SL
FFS
LP
KGGA
G
A
R
P
E
V
-
K
KELAV
L
M
RP
Q
VL
S
A
L
L
T
TV
L
G
AG
A
M
FT
L
Y
T
YI
S
P
V
LQ
S
IT
H
A
T
PV
F
V
TA
M
L
V
LIG
V
G
FS
IGN
Y
L
G
GKL
AD
R
S
VN---G
T
LKG
FLL
L
L
MV
I
ML
A
IP
F
L
A
RN
E
FGAA
I
S
---
MVV
WGAA
T
FAV
VP
PLQM
R
V
M
RV
A
SE
A
PG
L
SS
S
VNI
GAFNLG
N
A
L
GA
AA
GG
A
V
I
S
-
A
GL
G
YS
F
V
PVM
GAI
V-
-
A
G
L
A
-
L
LLVF
M
S
ARK
QPETVCVANS
fig|358709.5.peg.1173
Escherichia coli 101-1
MKINYP
L
LALA
I
GAFG
I
GTTEF
S
PMGLL
PV
IA
RG
V
D
VSIPAAG
M
L
IS
A
YA
V
GV
M
VGAP
LMT
L
LL
S
HRA
RR
SA
LIFL
M
A
I
F
TL
GNVLS
A
IA
P
D
Y
MT
L
M
L
SRI
LTS
L
N
HGAFFGLG
S
V
VA
AS
V
V
P
K
H
K
Q
A
S
AVA
T
M
FM
G
L
TLAN
I
G
GVP
AA
T
W
LG
E
T
I
GWRM
S
FLA
T
A
GLG
VI
S
M
V
SL
FFS
LP
KGGA
G
A
R
P
E
V
-
K
KELAV
L
M
RP
Q
VL
S
A
L
L
T
TV
L
G
AG
A
M
FT
L
Y
T
YI
S
P
V
LQ
S
IT
H
A
T
PV
F
V
TA
M
L
V
LIG
V
G
FS
IGN
Y
L
G
GKL
AD
R
S
VN---G
T
LKG
FLL
L
L
MV
I
ML
A
IP
F
L
A
RN
E
FGAA
I
S
---
MVV
WGAA
T
FAV
VP
PLQM
R
V
M
RV
A
SE
A
PG
L
SS
S
VNI
GAFNLG
N
A
L
GA
AA
GG
A
V
I
S
-
A
GL
G
YS
F
V
PVM
GAI
V-
-
A
G
L
A
-
L
LLVF
M
S
ARK
QPETVCVANS
fig|670888.3.peg.154
Escherichia coli 1827-70
MKINYP
L
LALA
I
GAFG
I
GTTEF
S
PMGLL
PV
IA
RG
V
D
VSIPAAG
M
L
IS
A
YA
V
GV
M
VGAP
LMT
L
LL
S
HRA
RR
SA
LIFL
M
A
I
F
TL
GNVLS
A
IA
P
D
Y
MT
L
M
L
SRI
LTS
L
N
HGAFFGLG
S
V
VA
AS
V
V
P
K
H
K
Q
A
S
AVA
T
M
FM
G
L
TLAN
I
G
GVP
AA
T
W
LG
E
T
I
GWRM
S
FLA
T
A
GLG
VI
S
M
V
SL
FFS
LP
KGGA
G
A
R
P
E
V
-
K
KELAV
L
M
RP
Q
VL
S
A
L
L
T
TV
L
G
AG
A
M
FT
L
Y
T
YI
S
P
V
LQ
S
IT
H
A
T
PV
F
V
TA
M
L
V
LIG
V
G
FS
IGN
Y
L
G
GKL
AD
R
S
VN---G
T
LKG
FLL
L
L
MV
I
ML
A
IP
F
L
A
RN
E
FGAA
I
S
---
MVV
WGAA
T
FAV
VP
PLQM
R
V
M
RV
A
SE
A
PG
L
SS
S
VNI
GAFNLG
N
A
L
GA
AA
GG
A
V
I
S
-
A
GL
G
YS
F
V
PVM
GAI
V-
-
A
G
L
A
-
L
LLVF
M
S
ARK
QPETVCVANS
fig|585055.6.peg.1853
Escherichia coli 55989
MKINYP
L
LALA
I
GAFG
I
GTTEF
S
PMGLL
PV
IA
RG
V
D
VSIPAAG
M
L
IS
A
YA
V
GV
M
VGAP
LMT
L
LL
S
HRA
RR
SA
LIFL
M
A
I
F
TL
GNVLS
A
IA
P
D
Y
MT
L
M
L
SRI
LTS
L
N
HGAFFGLG
S
V
VA
AS
V
V
P
K
H
K
Q
A
S
AVA
T
M
FM
G
L
TLAN
I
G
GVP
AA
T
W
LG
E
T
I
GWRM
S
FLA
T
A
GLG
VI
S
M
V
SL
FFS
LP
KGGA
G
A
R
P
E
V
-
K
KELAV
L
M
RP
Q
VL
S
A
L
L
T
TV
L
G
AG
A
M
FT
L
Y
T
YI
S
P
V
LQ
S
IT
H
A
T
PV
F
V
TA
M
L
V
LIG
V
G
FS
IGN
Y
L
G
GKL
AD
R
S
VN---G
T
LKG
FLL
L
L
MV
I
ML
A
IP
F
L
A
RN
E
FGAA
I
S
---
MVV
WGAA
T
FAV
VP
PLQM
R
V
M
RV
A
SE
A
PG
L
SS
S
VNI
GAFNLG
N
A
L
GA
AA
GG
A
V
I
S
-
A
GL
G
YS
F
V
PVM
GAI
V-
-
A
G
L
A
-
L
LLVF
M
S
ARK
QPETVCVANS
fig|585055.8.peg.1857
Escherichia coli 55989
MKINYP
L
LALA
I
GAFG
I
GTTEF
S
PMGLL
PV
IA
RG
V
D
VSIPAAG
M
L
IS
A
YA
V
GV
M
VGAP
LMT
L
LL
S
HRA
RR
SA
LIFL
M
A
I
F
TL
GNVLS
A
IA
P
D
Y
MT
L
M
L
SRI
LTS
L
N
HGAFFGLG
S
V
VA
AS
V
V
P
K
H
K
Q
A
S
AVA
T
M
FM
G
L
TLAN
I
G
GVP
AA
T
W
LG
E
T
I
GWRM
S
FLA
T
A
GLG
VI
S
M
V
SL
FFS
LP
KGGA
G
A
R
P
E
V
-
K
KELAV
L
M
RP
Q
VL
S
A
L
L
T
TV
L
G
AG
A
M
FT
L
Y
T
YI
S
P
V
LQ
S
IT
H
A
T
PV
F
V
TA
M
L
V
LIG
V
G
FS
IGN
Y
L
G
GKL
AD
R
S
VN---G
T
LKG
FLL
L
L
MV
I
ML
A
IP
F
L
A
RN
E
FGAA
I
S
---
MVV
WGAA
T
FAV
VP
PLQM
R
V
M
RV
A
SE
A
PG
L
SS
S
VNI
GAFNLG
N
A
L
GA
AA
GG
A
V
I
S
-
A
GL
G
YS
F
V
PVM
GAI
V-
-
A
G
L
A
-
L
LLVF
M
S
ARK
QPETVCVANS
fig|481805.3.peg.2126
Escherichia coli ATCC 8739
MKINYP
L
LALA
I
GAFG
I
GTTEF
S
PMGLL
PV
IA
RG
V
D
VSIPAAG
M
L
IS
A
YA
V
GV
M
VGAP
LMT
L
LL
S
HRA
RR
SA
LIFL
M
A
I
F
TL
GNVLS
A
IA
P
D
Y
MT
L
M
L
SRI
LTS
L
N
HGAFFGLG
S
V
VA
AS
V
V
P
K
H
K
Q
A
S
AVA
T
M
FM
G
L
TLAN
I
G
GVP
AA
T
W
LG
E
T
I
GWRM
S
FLA
T
A
GLG
VI
S
M
V
SL
FFS
LP
KGGA
G
A
R
P
E
V
-
K
KELAV
L
M
RP
Q
VL
S
A
L
L
T
TV
L
G
AG
A
M
FT
L
Y
T
YI
S
P
V
LQ
S
IT
H
A
T
PV
F
V
TA
M
L
V
LIG
V
G
FS
IGN
Y
L
G
GKL
AD
R
S
VN---G
T
LKG
FLL
L
L
MV
I
ML
A
IP
F
L
A
RN
E
FGAA
I
S
---
MVV
WGAA
T
FAV
VP
PLQM
R
V
M
RV
A
SE
A
PG
L
SS
S
VNI
GAFNLG
N
A
L
GA
AA
GG
A
V
I
S
-
A
GL
G
YS
F
V
PVM
GAI
V-
-
A
G
L
A
-
L
LLVF
M
S
ARK
QPETVCVANS
fig|481805.6.peg.2121
Escherichia coli ATCC 8739
MKINYP
L
LALA
I
GAFG
I
GTTEF
S
PMGLL
PV
IA
RG
V
D
VSIPAAG
M
L
IS
A
YA
V
GV
M
VGAP
LMT
L
LL
S
HRA
RR
SA
LIFL
M
A
I
F
TL
GNVLS
A
IA
P
D
Y
MT
L
M
L
SRI
LTS
L
N
HGAFFGLG
S
V
VA
AS
V
V
P
K
H
K
Q
A
S
AVA
T
M
FM
G
L
TLAN
I
G
GVP
AA
T
W
LG
E
T
I
GWRM
S
FLA
T
A
GLG
VI
S
M
V
SL
FFS
LP
KGGA
G
A
R
P
E
V
-
K
KELAV
L
M
RP
Q
VL
S
A
L
L
T
TV
L
G
AG
A
M
FT
L
Y
T
YI
S
P
V
LQ
S
IT
H
A
T
PV
F
V
TA
M
L
V
LIG
V
G
FS
IGN
Y
L
G
GKL
AD
R
S
VN---G
T
LKG
FLL
L
L
MV
I
ML
A
IP
F
L
A
RN
E
FGAA
I
S
---
MVV
WGAA
T
FAV
VP
PLQM
R
V
M
RV
A
SE
A
PG
L
SS
S
VNI
GAFNLG
N
A
L
GA
AA
GG
A
V
I
S
-
A
GL
G
YS
F
V
PVM
GAI
V-
-
A
G
L
A
-
L
LLVF
M
S
ARK
QPETVCVANS
fig|413997.3.peg.1702
Escherichia coli B str. REL606
MKINYP
L
LALA
I
GAFG
I
GTTEF
S
PMGLL
PV
IA
RG
V
D
VSIPAAG
M
L
IS
A
YA
V
GV
M
VGAP
LMT
L
LL
S
HRA
RR
SA
LIFL
M
A
I
F
TL
GNVLS
A
IA
P
D
Y
MT
L
M
L
SRI
LTS
L
N
HGAFFGLG
S
V
VA
AS
V
V
P
K
H
K
Q
A
S
AVA
T
M
FM
G
L
TLAN
I
G
GVP
AA
T
W
LG
E
T
I
GWRM
S
FLA
T
A
GLG
VI
S
M
V
SL
FFS
LP
KGGA
G
A
R
P
E
V
-
K
KELAV
L
M
RP
Q
VL
S
A
L
L
T
TV
L
G
AG
A
M
FT
L
Y
T
YI
S
P
V
LQ
S
IT
H
A
T
PV
F
V
TA
M
L
V
LIG
V
G
FS
IGN
Y
L
G
GKL
AD
R
S
VN---G
T
LKG
FLL
L
L
MV
I
ML
A
IP
F
L
A
RN
E
FGAA
I
S
---
MVV
WGAA
T
FAV
VP
PLQM
R
V
M
RV
A
SE
A
PG
L
SS
S
VNI
GAFNLG
N
A
L
GA
AA
GG
A
V
I
S
-
A
GL
G
YS
F
V
PVM
GAI
V-
-
A
G
L
A
-
L
LLVF
M
S
ARK
QPETVCVANS
fig|550672.3.peg.2499
Escherichia coli B088
MKINYP
L
LALA
I
GAFG
I
GTTEF
S
PMGLL
PV
IA
RG
V
D
VSIPAAG
M
L
IS
A
YA
V
GV
M
VGAP
LMT
L
LL
S
HRA
RR
SA
LIFL
M
A
I
F
TL
GNVLS
A
IA
P
D
Y
MT
L
M
L
SRI
LTS
L
N
HGAFFGLG
S
V
VA
AS
V
V
P
K
H
K
Q
A
S
AVA
T
M
FM
G
L
TLAN
I
G
GVP
AA
T
W
LG
E
T
I
GWRM
S
FLA
T
A
GLG
VI
S
M
V
SL
FFS
LP
KGGA
G
A
R
P
E
V
-
K
KELAV
L
M
RP
Q
VL
S
A
L
L
T
TV
L
G
AG
A
M
FT
L
Y
T
YI
S
P
V
LQ
S
IT
H
A
T
PV
F
V
TA
M
L
V
LIG
V
G
FS
IGN
Y
L
G
GKL
AD
R
S
VN---G
T
LKG
FLL
L
L
MV
I
ML
A
IP
F
L
A
RN
E
FGAA
I
S
---
MVV
WGAA
T
FAV
VP
PLQM
R
V
M
RV
A
SE
A
PG
L
SS
S
VNI
GAFNLG
N
A
L
GA
AA
GG
A
V
I
S
-
A
GL
G
YS
F
V
PVM
GAI
V-
-
A
G
L
A
-
L
LLVF
M
S
ARK
QPETVCVANS
fig|344601.3.peg.404
Escherichia coli B171
MKINYP
L
LALA
I
GAFG
I
GTTEF
S
PMGLL
PV
IA
RG
V
D
VSIPAAG
M
L
IS
A
YA
V
GV
M
VGAP
LMT
L
LL
S
HRA
RR
SA
LIFL
M
A
I
F
TL
GNVLS
A
IA
P
D
Y
MT
L
M
L
SRI
LTS
L
N
HGAFFGLG
S
V
VA
AS
V
V
P
K
H
K
Q
A
S
AVA
T
M
FM
G
L
TLAN
I
G
GVP
AA
T
W
LG
E
T
I
GWRM
S
FLA
T
A
GLG
VI
S
M
V
SL
FFS
LP
KGGA
G
A
R
P
E
V
-
K
KELAV
L
M
RP
Q
VL
S
A
L
L
T
TV
L
G
AG
A
M
FT
L
Y
T
YI
S
P
V
LQ
S
IT
H
A
T
PV
F
V
TA
M
L
V
LIG
V
G
FS
IGN
Y
L
G
GKL
AD
R
S
VN---G
T
LKG
FLL
L
L
MV
I
ML
A
IP
F
L
A
RN
E
FGAA
I
S
---
MVV
WGAA
T
FAV
VP
PLQM
R
V
M
RV
A
SE
A
PG
L
SS
S
VNI
GAFNLG
N
A
L
GA
AA
GG
A
V
I
S
-
A
GL
G
YS
F
V
PVM
GAI
V-
-
A
G
L
A
-
L
LLVF
M
S
ARK
QPETVCVANS
fig|344601.5.peg.402
Escherichia coli B171
MKINYP
L
LALA
I
GAFG
I
GTTEF
S
PMGLL
PV
IA
RG
V
D
VSIPAAG
M
L
IS
A
YA
V
GV
M
VGAP
LMT
L
LL
S
HRA
RR
SA
LIFL
M
A
I
F
TL
GNVLS
A
IA
P
D
Y
MT
L
M
L
SRI
LTS
L
N
HGAFFGLG
S
V
VA
AS
V
V
P
K
H
K
Q
A
S
AVA
T
M
FM
G
L
TLAN
I
G
GVP
AA
T
W
LG
E
T
I
GWRM
S
FLA
T
A
GLG
VI
S
M
V
SL
FFS
LP
KGGA
G
A
R
P
E
V
-
K
KELAV
L
M
RP
Q
VL
S
A
L
L
T
TV
L
G
AG
A
M
FT
L
Y
T
YI
S
P
V
LQ
S
IT
H
A
T
PV
F
V
TA
M
L
V
LIG
V
G
FS
IGN
Y
L
G
GKL
AD
R
S
VN---G
T
LKG
FLL
L
L
MV
I
ML
A
IP
F
L
A
RN
E
FGAA
I
S
---
MVV
WGAA
T
FAV
VP
PLQM
R
V
M
RV
A
SE
A
PG
L
SS
S
VNI
GAFNLG
N
A
L
GA
AA
GG
A
V
I
S
-
A
GL
G
YS
F
V
PVM
GAI
V-
-
A
G
L
A
-
L
LLVF
M
S
ARK
QPETVCVANS
fig|550676.3.peg.1964
Escherichia coli B185
MKINYP
L
LALA
I
GAFG
I
GTTEF
S
PMGLL
PV
IA
RG
V
D
VSIPAAG
M
L
IS
A
YA
V
GV
M
VGAP
LMT
L
LL
S
HRA
RR
SA
LIFL
M
A
I
F
TL
GNVLS
A
IA
P
D
Y
MT
L
M
L
SRI
LTS
L
N
HGAFFGLG
S
V
VA
AS
V
V
P
K
H
K
Q
A
S
AVA
T
M
FM
G
L
TLAN
I
G
GVP
AA
T
W
LG
E
T
I
GWRM
S
FLA
T
A
GLG
VI
S
M
V
SL
FFS
LP
KGGA
G
A
R
P
E
V
-
K
KELAV
L
M
RP
Q
VL
S
A
L
L
T
TV
L
G
AG
A
M
FT
L
Y
T
YI
S
P
V
LQ
S
IT
H
A
T
PV
F
V
TA
M
L
V
LIG
V
G
FS
IGN
Y
L
G
GKL
AD
R
S
VN---G
T
LKG
FLL
L
L
MV
I
ML
A
IP
F
L
A
RN
E
FGAA
I
S
---
MVV
WGAA
T
FAV
VP
PLQM
R
V
M
RV
A
SE
A
PG
L
SS
S
VNI
GAFNLG
N
A
L
GA
AA
GG
A
V
I
S
-
A
GL
G
YS
F
V
PVM
GAI
V-
-
A
G
L
A
-
L
LLVF
M
S
ARK
QPETVCVANS
fig|550677.3.peg.3043
Escherichia coli B354
MKINYP
L
LALA
I
GAFG
I
GTTEF
S
PMGLL
PV
IA
RG
V
D
VSIPAAG
M
L
IS
A
YA
V
GV
M
VGAP
LMT
L
LL
S
HRA
RR
SA
LIFL
M
A
I
F
TL
GNVLS
A
IA
P
D
Y
MT
L
M
L
SRI
LTS
L
N
HGAFFGLG
S
V
VA
AS
V
V
P
K
H
K
Q
A
S
AVA
T
M
FM
G
L
TLAN
I
G
GVP
AA
T
W
LG
E
T
I
GWRM
S
FLA
T
A
GLG
VI
S
M
V
SL
FFS
LP
KGGA
G
A
R
P
E
V
-
K
KELAV
L
M
RP
Q
VL
S
A
L
L
T
TV
L
G
AG
A
M
FT
L
Y
T
YI
S
P
V
LQ
S
IT
H
A
T
PV
F
V
TA
M
L
V
LIG
V
G
FS
IGN
Y
L
G
GKL
AD
R
S
VN---G
T
LKG
FLL
L
L
MV
I
ML
A
IP
F
L
A
RN
E
FGAA
I
S
---
MVV
WGAA
T
FAV
VP
PLQM
R
V
M
RV
A
SE
A
PG
L
SS
S
VNI
GAFNLG
N
A
L
GA
AA
GG
A
V
I
S
-
A
GL
G
YS
F
V
PVM
GAI
V-
-
A
G
L
A
-
L
LLVF
M
S
ARK
QPETVCVANS
fig|511693.5.peg.1729
Escherichia coli BL21
MKINYP
L
LALA
I
GAFG
I
GTTEF
S
PMGLL
PV
IA
RG
V
D
VSIPAAG
M
L
IS
A
YA
V
GV
M
VGAP
LMT
L
LL
S
HRA
RR
SA
LIFL
M
A
I
F
TL
GNVLS
A
IA
P
D
Y
MT
L
M
L
SRI
LTS
L
N
HGAFFGLG
S
V
VA
AS
V
V
P
K
H
K
Q
A
S
AVA
T
M
FM
G
L
TLAN
I
G
GVP
AA
T
W
LG
E
T
I
GWRM
S
FLA
T
A
GLG
VI
S
M
V
SL
FFS
LP
KGGA
G
A
R
P
E
V
-
K
KELAV
L
M
RP
Q
VL
S
A
L
L
T
TV
L
G
AG
A
M
FT
L
Y
T
YI
S
P
V
LQ
S
IT
H
A
T
PV
F
V
TA
M
L
V
LIG
V
G
FS
IGN
Y
L
G
GKL
AD
R
S
VN---G
T
LKG
FLL
L
L
MV
I
ML
A
IP
F
L
A
RN
E
FGAA
I
S
---
MVV
WGAA
T
FAV
VP
PLQM
R
V
M
RV
A
SE
A
PG
L
SS
S
VNI
GAFNLG
N
A
L
GA
AA
GG
A
V
I
S
-
A
GL
G
YS
F
V
PVM
GAI
V-
-
A
G
L
A
-
L
LLVF
M
S
ARK
QPETVCVANS
fig|469008.4.peg.2047
Escherichia coli BL21(DE3)
MKINYP
L
LALA
I
GAFG
I
GTTEF
S
PMGLL
PV
IA
RG
V
D
VSIPAAG
M
L
IS
A
YA
V
GV
M
VGAP
LMT
L
LL
S
HRA
RR
SA
LIFL
M
A
I
F
TL
GNVLS
A
IA
P
D
Y
MT
L
M
L
SRI
LTS
L
N
HGAFFGLG
S
V
VA
AS
V
V
P
K
H
K
Q
A
S
AVA
T
M
FM
G
L
TLAN
I
G
GVP
AA
T
W
LG
E
T
I
GWRM
S
FLA
T
A
GLG
VI
S
M
V
SL
FFS
LP
KGGA
G
A
R
P
E
V
-
K
KELAV
L
M
RP
Q
VL
S
A
L
L
T
TV
L
G
AG
A
M
FT
L
Y
T
YI
S
P
V
LQ
S
IT
H
A
T
PV
F
V
TA
M
L
V
LIG
V
G
FS
IGN
Y
L
G
GKL
AD
R
S
VN---G
T
LKG
FLL
L
L
MV
I
ML
A
IP
F
L
A
RN
E
FGAA
I
S
---
MVV
WGAA
T
FAV
VP
PLQM
R
V
M
RV
A
SE
A
PG
L
SS
S
VNI
GAFNLG
N
A
L
GA
AA
GG
A
V
I
S
-
A
GL
G
YS
F
V
PVM
GAI
V-
-
A
G
L
A
-
L
LLVF
M
S
ARK
QPETVCVANS
fig|595496.3.peg.1618
Escherichia coli BW2952
MKINYP
L
LALA
I
GAFG
I
GTTEF
S
PMGLL
PV
IA
RG
V
D
VSIPAAG
M
L
IS
A
YA
V
GV
M
VGAP
LMT
L
LL
S
HRA
RR
SA
LIFL
M
A
I
F
TL
GNVLS
A
IA
P
D
Y
MT
L
M
L
SRI
LTS
L
N
HGAFFGLG
S
V
VA
AS
V
V
P
K
H
K
Q
A
S
AVA
T
M
FM
G
L
TLAN
I
G
GVP
AA
T
W
LG
E
T
I
GWRM
S
FLA
T
A
GLG
VI
S
M
V
SL
FFS
LP
KGGA
G
A
R
P
E
V
-
K
KELAV
L
M
RP
Q
VL
S
A
L
L
T
TV
L
G
AG
A
M
FT
L
Y
T
YI
S
P
V
LQ
S
IT
H
A
T
PV
F
V
TA
M
L
V
LIG
V
G
FS
IGN
Y
L
G
GKL
AD
R
S
VN---G
T
LKG
FLL
L
L
MV
I
ML
A
IP
F
L
A
RN
E
FGAA
I
S
---
MVV
WGAA
T
FAV
VP
PLQM
R
V
M
RV
A
SE
A
PG
L
SS
S
VNI
GAFNLG
N
A
L
GA
AA
GG
A
V
I
S
-
A
GL
G
YS
F
V
PVM
GAI
V-
-
A
G
L
A
-
L
LLVF
M
S
ARK
QPETVCVANS
fig|536056.3.peg.2096
Escherichia coli DH1
MKINYP
L
LALA
I
GAFG
I
GTTEF
S
PMGLL
PV
IA
RG
V
D
VSIPAAG
M
L
IS
A
YA
V
GV
M
VGAP
LMT
L
LL
S
HRA
RR
SA
LIFL
M
A
I
F
TL
GNVLS
A
IA
P
D
Y
MT
L
M
L
SRI
LTS
L
N
HGAFFGLG
S
V
VA
AS
V
V
P
K
H
K
Q
A
S
AVA
T
M
FM
G
L
TLAN
I
G
GVP
AA
T
W
LG
E
T
I
GWRM
S
FLA
T
A
GLG
VI
S
M
V
SL
FFS
LP
KGGA
G
A
R
P
E
V
-
K
KELAV
L
M
RP
Q
VL
S
A
L
L
T
TV
L
G
AG
A
M
FT
L
Y
T
YI
S
P
V
LQ
S
IT
H
A
T
PV
F
V
TA
M
L
V
LIG
V
G
FS
IGN
Y
L
G
GKL
AD
R
S
VN---G
T
LKG
FLL
L
L
MV
I
ML
A
IP
F
L
A
RN
E
FGAA
I
S
---
MVV
WGAA
T
FAV
VP
PLQM
R
V
M
RV
A
SE
A
PG
L
SS
S
VNI
GAFNLG
N
A
L
GA
AA
GG
A
V
I
S
-
A
GL
G
YS
F
V
PVM
GAI
V-
-
A
G
L
A
-
L
LLVF
M
S
ARK
QPETVCVANS
fig|340186.3.peg.3485
Escherichia coli E110019
MKINYP
L
LALA
I
GAFG
I
GTTEF
S
PMGLL
PV
IA
RG
V
D
VSIPAAG
M
L
IS
A
YA
V
GV
M
VGAP
LMT
L
LL
S
HRA
RR
SA
LIFL
M
A
I
F
TL
GNVLS
A
IA
P
D
Y
MT
L
M
L
SRI
LTS
L
N
HGAFFGLG
S
V
VA
AS
V
V
P
K
H
K
Q
A
S
AVA
T
M
FM
G
L
TLAN
I
G
GVP
AA
T
W
LG
E
T
I
GWRM
S
FLA
T
A
GLG
VI
S
M
V
SL
FFS
LP
KGGA
G
A
R
P
E
V
-
K
KELAV
L
M
RP
Q
VL
S
A
L
L
T
TV
L
G
AG
A
M
FT
L
Y
T
YI
S
P
V
LQ
S
IT
H
A
T
PV
F
V
TA
M
L
V
LIG
V
G
FS
IGN
Y
L
G
GKL
AD
R
S
VN---G
T
LKG
FLL
L
L
MV
I
ML
A
IP
F
L
A
RN
E
FGAA
I
S
---
MVV
WGAA
T
FAV
VP
PLQM
R
V
M
RV
A
SE
A
PG
L
SS
S
VNI
GAFNLG
N
A
L
GA
AA
GG
A
V
I
S
-
A
GL
G
YS
F
V
PVM
GAI
V-
-
A
G
L
A
-
L
LLVF
M
S
ARK
QPETVCVANS
fig|340186.5.peg.3638
Escherichia coli E110019
MKINYP
L
LALA
I
GAFG
I
GTTEF
S
PMGLL
PV
IA
RG
V
D
VSIPAAG
M
L
IS
A
YA
V
GV
M
VGAP
LMT
L
LL
S
HRA
RR
SA
LIFL
M
A
I
F
TL
GNVLS
A
IA
P
D
Y
MT
L
M
L
SRI
LTS
L
N
HGAFFGLG
S
V
VA
AS
V
V
P
K
H
K
Q
A
S
AVA
T
M
FM
G
L
TLAN
I
G
GVP
AA
T
W
LG
E
T
I
GWRM
S
FLA
T
A
GLG
VI
S
M
V
SL
FFS
LP
KGGA
G
A
R
P
E
V
-
K
KELAV
L
M
RP
Q
VL
S
A
L
L
T
TV
L
G
AG
A
M
FT
L
Y
T
YI
S
P
V
LQ
S
IT
H
A
T
PV
F
V
TA
M
L
V
LIG
V
G
FS
IGN
Y
L
G
GKL
AD
R
S
VN---G
T
LKG
FLL
L
L
MV
I
ML
A
IP
F
L
A
RN
E
FGAA
I
S
---
MVV
WGAA
T
FAV
VP
PLQM
R
V
M
RV
A
SE
A
PG
L
SS
S
VNI
GAFNLG
N
A
L
GA
AA
GG
A
V
I
S
-
A
GL
G
YS
F
V
PVM
GAI
V-
-
A
G
L
A
-
L
LLVF
M
S
ARK
QPETVCVANS
fig|331111.12.peg.2153
Escherichia coli E24377A
MKINYP
L
LALA
I
GAFG
I
GTTEF
S
PMGLL
PV
IA
RG
V
D
VSIPAAG
M
L
IS
A
YA
V
GV
M
VGAP
LMT
L
LL
S
HRA
RR
SA
LIFL
M
A
I
F
TL
GNVLS
A
IA
P
D
Y
MT
L
M
L
SRI
LTS
L
N
HGAFFGLG
S
V
VA
AS
V
V
P
K
H
K
Q
A
S
AVA
T
M
FM
G
L
TLAN
I
G
GVP
AA
T
W
LG
E
T
I
GWRM
S
FLA
T
A
GLG
VI
S
M
V
SL
FFS
LP
KGGA
G
A
R
P
E
V
-
K
KELAV
L
M
RP
Q
VL
S
A
L
L
T
TV
L
G
AG
A
M
FT
L
Y
T
YI
S
P
V
LQ
S
IT
H
A
T
PV
F
V
TA
M
L
V
LIG
V
G
FS
IGN
Y
L
G
GKL
AD
R
S
VN---G
T
LKG
FLL
L
L
MV
I
ML
A
IP
F
L
A
RN
E
FGAA
I
S
---
MVV
WGAA
T
FAV
VP
PLQM
R
V
M
RV
A
SE
A
PG
L
SS
S
VNI
GAFNLG
N
A
L
GA
AA
GG
A
V
I
S
-
A
GL
G
YS
F
V
PVM
GAI
V-
-
A
G
L
A
-
L
LLVF
M
S
ARK
QPETVCVANS
fig|331111.3.peg.4296
Escherichia coli E24377A
MKINYP
L
LALA
I
GAFG
I
GTTEF
S
PMGLL
PV
IA
RG
V
D
VSIPAAG
M
L
IS
A
YA
V
GV
M
VGAP
LMT
L
LL
S
HRA
RR
SA
LIFL
M
A
I
F
TL
GNVLS
A
IA
P
D
Y
MT
L
M
L
SRI
LTS
L
N
HGAFFGLG
S
V
VA
AS
V
V
P
K
H
K
Q
A
S
AVA
T
M
FM
G
L
TLAN
I
G
GVP
AA
T
W
LG
E
T
I
GWRM
S
FLA
T
A
GLG
VI
S
M
V
SL
FFS
LP
KGGA
G
A
R
P
E
V
-
K
KELAV
L
M
RP
Q
VL
S
A
L
L
T
TV
L
G
AG
A
M
FT
L
Y
T
YI
S
P
V
LQ
S
IT
H
A
T
PV
F
V
TA
M
L
V
LIG
V
G
FS
IGN
Y
L
G
GKL
AD
R
S
VN---G
T
LKG
FLL
L
L
MV
I
ML
A
IP
F
L
A
RN
E
FGAA
I
S
---
MVV
WGAA
T
FAV
VP
PLQM
R
V
M
RV
A
SE
A
PG
L
SS
S
VNI
GAFNLG
N
A
L
GA
AA
GG
A
V
I
S
-
A
GL
G
YS
F
V
PVM
GAI
V-
-
A
G
L
A
-
L
LLVF
M
S
ARK
QPETVCVANS
fig|562.375.peg.1765
Escherichia coli EC4100B
MKINYP
L
LALA
I
GAFG
I
GTTEF
S
PMGLL
PV
IA
RG
V
D
VSIPAAG
M
L
IS
A
YA
V
GV
M
VGAP
LMT
L
LL
S
HRA
RR
SA
LIFL
M
A
I
F
TL
GNVLS
A
IA
P
D
Y
MT
L
M
L
SRI
LTS
L
N
HGAFFGLG
S
V
VA
AS
V
V
P
K
H
K
Q
A
S
AVA
T
M
FM
G
L
TLAN
I
G
GVP
AA
T
W
LG
E
T
I
GWRM
S
FLA
T
A
GLG
VI
S
M
V
SL
FFS
LP
KGGA
G
A
R
P
E
V
-
K
KELAV
L
M
RP
Q
VL
S
A
L
L
T
TV
L
G
AG
A
M
FT
L
Y
T
YI
S
P
V
LQ
S
IT
H
A
T
PV
F
V
TA
M
L
V
LIG
V
G
FS
IGN
Y
L
G
GKL
AD
R
S
VN---G
T
LKG
FLL
L
L
MV
I
ML
A
IP
F
L
A
RN
E
FGAA
I
S
---
MVV
WGAA
T
FAV
VP
PLQM
R
V
M
RV
A
SE
A
PG
L
SS
S
VNI
GAFNLG
N
A
L
GA
AA
GG
A
V
I
S
-
A
GL
G
YS
F
V
PVM
GAI
V-
-
A
G
L
A
-
L
LLVF
M
S
ARK
QPETVCVANS
fig|656379.3.peg.2130
Escherichia coli FVEC1302
MKINYP
L
LALA
I
GAFG
I
GTTEF
S
PMGLL
PV
IA
RG
V
D
VSIPAAG
M
L
IS
A
YA
V
GV
M
VGAP
LMT
L
LL
S
HRA
RR
SA
LIFL
M
A
I
F
TL
GNVLS
A
IA
P
D
Y
MT
L
M
L
SRI
LTS
L
N
HGAFFGLG
S
V
VA
AS
V
V
P
K
H
K
Q
A
S
AVA
T
M
FM
G
L
TLAN
I
G
GVP
AA
T
W
LG
E
T
I
GWRM
S
FLA
T
A
GLG
VI
S
M
V
SL
FFS
LP
KGGA
G
A
R
P
E
V
-
K
KELAV
L
M
RP
Q
VL
S
A
L
L
T
TV
L
G
AG
A
M
FT
L
Y
T
YI
S
P
V
LQ
S
IT
H
A
T
PV
F
V
TA
M
L
V
LIG
V
G
FS
IGN
Y
L
G
GKL
AD
R
S
VN---G
T
LKG
FLL
L
L
MV
I
ML
A
IP
F
L
A
RN
E
FGAA
I
S
---
MVV
WGAA
T
FAV
VP
PLQM
R
V
M
RV
A
SE
A
PG
L
SS
S
VNI
GAFNLG
N
A
L
GA
AA
GG
A
V
I
S
-
A
GL
G
YS
F
V
PVM
GAI
V-
-
A
G
L
A
-
L
LLVF
M
S
ARK
QPETVCVANS
fig|656380.3.peg.3093
Escherichia coli FVEC1412
MKINYP
L
LALA
I
GAFG
I
GTTEF
S
PMGLL
PV
IA
RG
V
D
VSIPAAG
M
L
IS
A
YA
V
GV
M
VGAP
LMT
L
LL
S
HRA
RR
SA
LIFL
M
A
I
F
TL
GNVLS
A
IA
P
D
Y
MT
L
M
L
SRI
LTS
L
N
HGAFFGLG
S
V
VA
AS
V
V
P
K
H
K
Q
A
S
AVA
T
M
FM
G
L
TLAN
I
G
GVP
AA
T
W
LG
E
T
I
GWRM
S
FLA
T
A
GLG
VI
S
M
V
SL
FFS
LP
KGGA
G
A
R
P
E
V
-
K
KELAV
L
M
RP
Q
VL
S
A
L
L
T
TV
L
G
AG
A
M
FT
L
Y
T
YI
S
P
V
LQ
S
IT
H
A
T
PV
F
V
TA
M
L
V
LIG
V
G
FS
IGN
Y
L
G
GKL
AD
R
S
VN---G
T
LKG
FLL
L
L
MV
I
ML
A
IP
F
L
A
RN
E
FGAA
I
S
---
MVV
WGAA
T
FAV
VP
PLQM
R
V
M
RV
A
SE
A
PG
L
SS
S
VNI
GAFNLG
N
A
L
GA
AA
GG
A
V
I
S
-
A
GL
G
YS
F
V
PVM
GAI
V-
-
A
G
L
A
-
L
LLVF
M
S
ARK
QPETVCVANS
fig|656408.3.peg.1808
Escherichia coli H591
MKINYP
L
LALA
I
GAFG
I
GTTEF
S
PMGLL
PV
IA
RG
V
D
VSIPAAG
M
L
IS
A
YA
V
GV
M
VGAP
LMT
L
LL
S
HRA
RR
SA
LIFL
M
A
I
F
TL
GNVLS
A
IA
P
D
Y
MT
L
M
L
SRI
LTS
L
N
HGAFFGLG
S
V
VA
AS
V
V
P
K
H
K
Q
A
S
AVA
T
M
FM
G
L
TLAN
I
G
GVP
AA
T
W
LG
E
T
I
GWRM
S
FLA
T
A
GLG
VI
S
M
V
SL
FFS
LP
KGGA
G
A
R
P
E
V
-
K
KELAV
L
M
RP
Q
VL
S
A
L
L
T
TV
L
G
AG
A
M
FT
L
Y
T
YI
S
P
V
LQ
S
IT
H
A
T
PV
F
V
TA
M
L
V
LIG
V
G
FS
IGN
Y
L
G
GKL
AD
R
S
VN---G
T
LKG
FLL
L
L
MV
I
ML
A
IP
F
L
A
RN
E
FGAA
I
S
---
MVV
WGAA
T
FAV
VP
PLQM
R
V
M
RV
A
SE
A
PG
L
SS
S
VNI
GAFNLG
N
A
L
GA
AA
GG
A
V
I
S
-
A
GL
G
YS
F
V
PVM
GAI
V-
-
A
G
L
A
-
L
LLVF
M
S
ARK
QPETVCVANS
fig|656414.3.peg.1972
Escherichia coli H736
MKINYP
L
LALA
I
GAFG
I
GTTEF
S
PMGLL
PV
IA
RG
V
D
VSIPAAG
M
L
IS
A
YA
V
GV
M
VGAP
LMT
L
LL
S
HRA
RR
SA
LIFL
M
A
I
F
TL
GNVLS
A
IA
P
D
Y
MT
L
M
L
SRI
LTS
L
N
HGAFFGLG
S
V
VA
AS
V
V
P
K
H
K
Q
A
S
AVA
T
M
FM
G
L
TLAN
I
G
GVP
AA
T
W
LG
E
T
I
GWRM
S
FLA
T
A
GLG
VI
S
M
V
SL
FFS
LP
KGGA
G
A
R
P
E
V
-
K
KELAV
L
M
RP
Q
VL
S
A
L
L
T
TV
L
G
AG
A
M
FT
L
Y
T
YI
S
P
V
LQ
S
IT
H
A
T
PV
F
V
TA
M
L
V
LIG
V
G
FS
IGN
Y
L
G
GKL
AD
R
S
VN---G
T
LKG
FLL
L
L
MV
I
ML
A
IP
F
L
A
RN
E
FGAA
I
S
---
MVV
WGAA
T
FAV
VP
PLQM
R
V
M
RV
A
SE
A
PG
L
SS
S
VNI
GAFNLG
N
A
L
GA
AA
GG
A
V
I
S
-
A
GL
G
YS
F
V
PVM
GAI
V-
-
A
G
L
A
-
L
LLVF
M
S
ARK
QPETVCVANS
fig|331112.3.peg.1634
Escherichia coli HS
MKINYP
L
LALA
I
GAFG
I
GTTEF
S
PMGLL
PV
IA
RG
V
D
VSIPAAG
M
L
IS
A
YA
V
GV
M
VGAP
LMT
L
LL
S
HRA
RR
SA
LIFL
M
A
I
F
TL
GNVLS
A
IA
P
D
Y
MT
L
M
L
SRI
LTS
L
N
HGAFFGLG
S
V
VA
AS
V
V
P
K
H
K
Q
A
S
AVA
T
M
FM
G
L
TLAN
I
G
GVP
AA
T
W
LG
E
T
I
GWRM
S
FLA
T
A
GLG
VI
S
M
V
SL
FFS
LP
KGGA
G
A
R
P
E
V
-
K
KELAV
L
M
RP
Q
VL
S
A
L
L
T
TV
L
G
AG
A
M
FT
L
Y
T
YI
S
P
V
LQ
S
IT
H
A
T
PV
F
V
TA
M
L
V
LIG
V
G
FS
IGN
Y
L
G
GKL
AD
R
S
VN---G
T
LKG
FLL
L
L
MV
I
ML
A
IP
F
L
A
RN
E
FGAA
I
S
---
MVV
WGAA
T
FAV
VP
PLQM
R
V
M
RV
A
SE
A
PG
L
SS
S
VNI
GAFNLG
N
A
L
GA
AA
GG
A
V
I
S
-
A
GL
G
YS
F
V
PVM
GAI
V-
-
A
G
L
A
-
L
LLVF
M
S
ARK
QPETVCVANS
fig|331112.6.peg.1701
Escherichia coli HS
MKINYP
L
LALA
I
GAFG
I
GTTEF
S
PMGLL
PV
IA
RG
V
D
VSIPAAG
M
L
IS
A
YA
V
GV
M
VGAP
LMT
L
LL
S
HRA
RR
SA
LIFL
M
A
I
F
TL
GNVLS
A
IA
P
D
Y
MT
L
M
L
SRI
LTS
L
N
HGAFFGLG
S
V
VA
AS
V
V
P
K
H
K
Q
A
S
AVA
T
M
FM
G
L
TLAN
I
G
GVP
AA
T
W
LG
E
T
I
GWRM
S
FLA
T
A
GLG
VI
S
M
V
SL
FFS
LP
KGGA
G
A
R
P
E
V
-
K
KELAV
L
M
RP
Q
VL
S
A
L
L
T
TV
L
G
AG
A
M
FT
L
Y
T
YI
S
P
V
LQ
S
IT
H
A
T
PV
F
V
TA
M
L
V
LIG
V
G
FS
IGN
Y
L
G
GKL
AD
R
S
VN---G
T
LKG
FLL
L
L
MV
I
ML
A
IP
F
L
A
RN
E
FGAA
I
S
---
MVV
WGAA
T
FAV
VP
PLQM
R
V
M
RV
A
SE
A
PG
L
SS
S
VNI
GAFNLG
N
A
L
GA
AA
GG
A
V
I
S
-
A
GL
G
YS
F
V
PVM
GAI
V-
-
A
G
L
A
-
L
LLVF
M
S
ARK
QPETVCVANS
fig|585034.4.peg.1693
Escherichia coli IAI1
MKINYP
L
LALA
I
GAFG
I
GTTEF
S
PMGLL
PV
IA
RG
V
D
VSIPAAG
M
L
IS
A
YA
V
GV
M
VGAP
LMT
L
LL
S
HRA
RR
SA
LIFL
M
A
I
F
TL
GNVLS
A
IA
P
D
Y
MT
L
M
L
SRI
LTS
L
N
HGAFFGLG
S
V
VA
AS
V
V
P
K
H
K
Q
A
S
AVA
T
M
FM
G
L
TLAN
I
G
GVP
AA
T
W
LG
E
T
I
GWRM
S
FLA
T
A
GLG
VI
S
M
V
SL
FFS
LP
KGGA
G
A
R
P
E
V
-
K
KELAV
L
M
RP
Q
VL
S
A
L
L
T
TV
L
G
AG
A
M
FT
L
Y
T
YI
S
P
V
LQ
S
IT
H
A
T
PV
F
V
TA
M
L
V
LIG
V
G
FS
IGN
Y
L
G
GKL
AD
R
S
VN---G
T
LKG
FLL
L
L
MV
I
ML
A
IP
F
L
A
RN
E
FGAA
I
S
---
MVV
WGAA
T
FAV
VP
PLQM
R
V
M
RV
A
SE
A
PG
L
SS
S
VNI
GAFNLG
N
A
L
GA
AA
GG
A
V
I
S
-
A
GL
G
YS
F
V
PVM
GAI
V-
-
A
G
L
A
-
L
LLVF
M
S
ARK
QPETVCVANS
fig|585034.5.peg.1688
Escherichia coli IAI1
MKINYP
L
LALA
I
GAFG
I
GTTEF
S
PMGLL
PV
IA
RG
V
D
VSIPAAG
M
L
IS
A
YA
V
GV
M
VGAP
LMT
L
LL
S
HRA
RR
SA
LIFL
M
A
I
F
TL
GNVLS
A
IA
P
D
Y
MT
L
M
L
SRI
LTS
L
N
HGAFFGLG
S
V
VA
AS
V
V
P
K
H
K
Q
A
S
AVA
T
M
FM
G
L
TLAN
I
G
GVP
AA
T
W
LG
E
T
I
GWRM
S
FLA
T
A
GLG
VI
S
M
V
SL
FFS
LP
KGGA
G
A
R
P
E
V
-
K
KELAV
L
M
RP
Q
VL
S
A
L
L
T
TV
L
G
AG
A
M
FT
L
Y
T
YI
S
P
V
LQ
S
IT
H
A
T
PV
F
V
TA
M
L
V
LIG
V
G
FS
IGN
Y
L
G
GKL
AD
R
S
VN---G
T
LKG
FLL
L
L
MV
I
ML
A
IP
F
L
A
RN
E
FGAA
I
S
---
MVV
WGAA
T
FAV
VP
PLQM
R
V
M
RV
A
SE
A
PG
L
SS
S
VNI
GAFNLG
N
A
L
GA
AA
GG
A
V
I
S
-
A
GL
G
YS
F
V
PVM
GAI
V-
-
A
G
L
A
-
L
LLVF
M
S
ARK
QPETVCVANS
fig|83333.1.peg.1643
Escherichia coli K12
MKINYP
L
LALA
I
GAFG
I
GTTEF
S
PMGLL
PV
IA
RG
V
D
VSIPAAG
M
L
IS
A
YA
V
GV
M
VGAP
LMT
L
LL
S
HRA
RR
SA
LIFL
M
A
I
F
TL
GNVLS
A
IA
P
D
Y
MT
L
M
L
SRI
LTS
L
N
HGAFFGLG
S
V
VA
AS
V
V
P
K
H
K
Q
A
S
AVA
T
M
FM
G
L
TLAN
I
G
GVP
AA
T
W
LG
E
T
I
GWRM
S
FLA
T
A
GLG
VI
S
M
V
SL
FFS
LP
KGGA
G
A
R
P
E
V
-
K
KELAV
L
M
RP
Q
VL
S
A
L
L
T
TV
L
G
AG
A
M
FT
L
Y
T
YI
S
P
V
LQ
S
IT
H
A
T
PV
F
V
TA
M
L
V
LIG
V
G
FS
IGN
Y
L
G
GKL
AD
R
S
VN---G
T
LKG
FLL
L
L
MV
I
ML
A
IP
F
L
A
RN
E
FGAA
I
S
---
MVV
WGAA
T
FAV
VP
PLQM
R
V
M
RV
A
SE
A
PG
L
SS
S
VNI
GAFNLG
N
A
L
GA
AA
GG
A
V
I
S
-
A
GL
G
YS
F
V
PVM
GAI
V-
-
A
G
L
A
-
L
LLVF
M
S
ARK
QPETVCVANS
fig|595495.4.peg.4296
Escherichia coli KO11
MKINYP
L
LALA
I
GAFG
I
GTTEF
S
PMGLL
PV
IA
RG
V
D
VSIPAAG
M
L
IS
A
YA
V
GV
M
VGAP
LMT
L
LL
S
HRA
RR
SA
LIFL
M
A
I
F
TL
GNVLS
A
IA
P
D
Y
MT
L
M
L
SRI
LTS
L
N
HGAFFGLG
S
V
VA
AS
V
V
P
K
H
K
Q
A
S
AVA
T
M
FM
G
L
TLAN
I
G
GVP
AA
T
W
LG
E
T
I
GWRM
S
FLA
T
A
GLG
VI
S
M
V
SL
FFS
LP
KGGA
G
A
R
P
E
V
-
K
KELAV
L
M
RP
Q
VL
S
A
L
L
T
TV
L
G
AG
A
M
FT
L
Y
T
YI
S
P
V
LQ
S
IT
H
A
T
PV
F
V
TA
M
L
V
LIG
V
G
FS
IGN
Y
L
G
GKL
AD
R
S
VN---G
T
LKG
FLL
L
L
MV
I
ML
A
IP
F
L
A
RN
E
FGAA
I
S
---
MVV
WGAA
T
FAV
VP
PLQM
R
V
M
RV
A
SE
A
PG
L
SS
S
VNI
GAFNLG
N
A
L
GA
AA
GG
A
V
I
S
-
A
GL
G
YS
F
V
PVM
GAI
V-
-
A
G
L
A
-
L
LLVF
M
S
ARK
QPETVCVANS
fig|656419.3.peg.2367
Escherichia coli M718
MKINYP
L
LALA
I
GAFG
I
GTTEF
S
PMGLL
PV
IA
RG
V
D
VSIPAAG
M
L
IS
A
YA
V
GV
M
VGAP
LMT
L
LL
S
HRA
RR
SA
LIFL
M
A
I
F
TL
GNVLS
A
IA
P
D
Y
MT
L
M
L
SRI
LTS
L
N
HGAFFGLG
S
V
VA
AS
V
V
P
K
H
K
Q
A
S
AVA
T
M
FM
G
L
TLAN
I
G
GVP
AA
T
W
LG
E
T
I
GWRM
S
FLA
T
A
GLG
VI
S
M
V
SL
FFS
LP
KGGA
G
A
R
P
E
V
-
K
KELAV
L
M
RP
Q
VL
S
A
L
L
T
TV
L
G
AG
A
M
FT
L
Y
T
YI
S
P
V
LQ
S
IT
H
A
T
PV
F
V
TA
M
L
V
LIG
V
G
FS
IGN
Y
L
G
GKL
AD
R
S
VN---G
T
LKG
FLL
L
L
MV
I
ML
A
IP
F
L
A
RN
E
FGAA
I
S
---
MVV
WGAA
T
FAV
VP
PLQM
R
V
M
RV
A
SE
A
PG
L
SS
S
VNI
GAFNLG
N
A
L
GA
AA
GG
A
V
I
S
-
A
GL
G
YS
F
V
PVM
GAI
V-
-
A
G
L
A
-
L
LLVF
M
S
ARK
QPETVCVANS
fig|679207.4.peg.4521
Escherichia coli MS 107-1
MKINYP
L
LALA
I
GAFG
I
GTTEF
S
PMGLL
PV
IA
RG
V
D
VSIPAAG
M
L
IS
A
YA
V
GV
M
VGAP
LMT
L
LL
S
HRA
RR
SA
LIFL
M
A
I
F
TL
GNVLS
A
IA
P
D
Y
MT
L
M
L
SRI
LTS
L
N
HGAFFGLG
S
V
VA
AS
V
V
P
K
H
K
Q
A
S
AVA
T
M
FM
G
L
TLAN
I
G
GVP
AA
T
W
LG
E
T
I
GWRM
S
FLA
T
A
GLG
VI
S
M
V
SL
FFS
LP
KGGA
G
A
R
P
E
V
-
K
KELAV
L
M
RP
Q
VL
S
A
L
L
T
TV
L
G
AG
A
M
FT
L
Y
T
YI
S
P
V
LQ
S
IT
H
A
T
PV
F
V
TA
M
L
V
LIG
V
G
FS
IGN
Y
L
G
GKL
AD
R
S
VN---G
T
LKG
FLL
L
L
MV
I
ML
A
IP
F
L
A
RN
E
FGAA
I
S
---
MVV
WGAA
T
FAV
VP
PLQM
R
V
M
RV
A
SE
A
PG
L
SS
S
VNI
GAFNLG
N
A
L
GA
AA
GG
A
V
I
S
-
A
GL
G
YS
F
V
PVM
GAI
V-
-
A
G
L
A
-
L
LLVF
M
S
ARK
QPETVCVANS
fig|749537.3.peg.1733
Escherichia coli MS 115-1
MKINYP
L
LALA
I
GAFG
I
GTTEF
S
PMGLL
PV
IA
RG
V
D
VSIPAAG
M
L
IS
A
YA
V
GV
M
VGAP
LMT
L
LL
S
HRA
RR
SA
LIFL
M
A
I
F
TL
GNVLS
A
IA
P
D
Y
MT
L
M
L
SRI
LTS
L
N
HGAFFGLG
S
V
VA
AS
V
V
P
K
H
K
Q
A
S
AVA
T
M
FM
G
L
TLAN
I
G
GVP
AA
T
W
LG
E
T
I
GWRM
S
FLA
T
A
GLG
VI
S
M
V
SL
FFS
LP
KGGA
G
A
R
P
E
V
-
K
KELAV
L
M
RP
Q
VL
S
A
L
L
T
TV
L
G
AG
A
M
FT
L
Y
T
YI
S
P
V
LQ
S
IT
H
A
T
PV
F
V
TA
M
L
V
LIG
V
G
FS
IGN
Y
L
G
GKL
AD
R
S
VN---G
T
LKG
FLL
L
L
MV
I
ML
A
IP
F
L
A
RN
E
FGAA
I
S
---
MVV
WGAA
T
FAV
VP
PLQM
R
V
M
RV
A
SE
A
PG
L
SS
S
VNI
GAFNLG
N
A
L
GA
AA
GG
A
V
I
S
-
A
GL
G
YS
F
V
PVM
GAI
V-
-
A
G
L
A
-
L
LLVF
M
S
ARK
QPETVCVANS
fig|749538.3.peg.4636
Escherichia coli MS 116-1
MKINYP
L
LALA
I
GAFG
I
GTTEF
S
PMGLL
PV
IA
RG
V
D
VSIPAAG
M
L
IS
A
YA
V
GV
M
VGAP
LMT
L
LL
S
HRA
RR
SA
LIFL
M
A
I
F
TL
GNVLS
A
IA
P
D
Y
MT
L
M
L
SRI
LTS
L
N
HGAFFGLG
S
V
VA
AS
V
V
P
K
H
K
Q
A
S
AVA
T
M
FM
G
L
TLAN
I
G
GVP
AA
T
W
LG
E
T
I
GWRM
S
FLA
T
A
GLG
VI
S
M
V
SL
FFS
LP
KGGA
G
A
R
P
E
V
-
K
KELAV
L
M
RP
Q
VL
S
A
L
L
T
TV
L
G
AG
A
M
FT
L
Y
T
YI
S
P
V
LQ
S
IT
H
A
T
PV
F
V
TA
M
L
V
LIG
V
G
FS
IGN
Y
L
G
GKL
AD
R
S
VN---G
T
LKG
FLL
L
L
MV
I
ML
A
IP
F
L
A
RN
E
FGAA
I
S
---
MVV
WGAA
T
FAV
VP
PLQM
R
V
M
RV
A
SE
A
PG
L
SS
S
VNI
GAFNLG
N
A
L
GA
AA
GG
A
V
I
S
-
A
GL
G
YS
F
V
PVM
GAI
V-
-
A
G
L
A
-
L
LLVF
M
S
ARK
QPETVCVANS
fig|679206.4.peg.1237
Escherichia coli MS 119-7
MKINYP
L
LALA
I
GAFG
I
GTTEF
S
PMGLL
PV
IA
RG
V
D
VSIPAAG
M
L
IS
A
YA
V
GV
M
VGAP
LMT
L
LL
S
HRA
RR
SA
LIFL
M
A
I
F
TL
GNVLS
A
IA
P
D
Y
MT
L
M
L
SRI
LTS
L
N
HGAFFGLG
S
V
VA
AS
V
V
P
K
H
K
Q
A
S
AVA
T
M
FM
G
L
TLAN
I
G
GVP
AA
T
W
LG
E
T
I
GWRM
S
FLA
T
A
GLG
VI
S
M
V
SL
FFS
LP
KGGA
G
A
R
P
E
V
-
K
KELAV
L
M
RP
Q
VL
S
A
L
L
T
TV
L
G
AG
A
M
FT
L
Y
T
YI
S
P
V
LQ
S
IT
H
A
T
PV
F
V
TA
M
L
V
LIG
V
G
FS
IGN
Y
L
G
GKL
AD
R
S
VN---G
T
LKG
FLL
L
L
MV
I
ML
A
IP
F
L
A
RN
E
FGAA
I
S
---
MVV
WGAA
T
FAV
VP
PLQM
R
V
M
RV
A
SE
A
PG
L
SS
S
VNI
GAFNLG
N
A
L
GA
AA
GG
A
V
I
S
-
A
GL
G
YS
F
V
PVM
GAI
V-
-
A
G
L
A
-
L
LLVF
M
S
ARK
QPETVCVANS
fig|679205.4.peg.1695
Escherichia coli MS 124-1
MKINYP
L
LALA
I
GAFG
I
GTTEF
S
PMGLL
PV
IA
RG
V
D
VSIPAAG
M
L
IS
A
YA
V
GV
M
VGAP
LMT
L
LL
S
HRA
RR
SA
LIFL
M
A
I
F
TL
GNVLS
A
IA
P
D
Y
MT
L
M
L
SRI
LTS
L
N
HGAFFGLG
S
V
VA
AS
V
V
P
K
H
K
Q
A
S
AVA
T
M
FM
G
L
TLAN
I
G
GVP
AA
T
W
LG
E
T
I
GWRM
S
FLA
T
A
GLG
VI
S
M
V
SL
FFS
LP
KGGA
G
A
R
P
E
V
-
K
KELAV
L
M
RP
Q
VL
S
A
L
L
T
TV
L
G
AG
A
M
FT
L
Y
T
YI
S
P
V
LQ
S
IT
H
A
T
PV
F
V
TA
M
L
V
LIG
V
G
FS
IGN
Y
L
G
GKL
AD
R
S
VN---G
T
LKG
FLL
L
L
MV
I
ML
A
IP
F
L
A
RN
E
FGAA
I
S
---
MVV
WGAA
T
FAV
VP
PLQM
R
V
M
RV
A
SE
A
PG
L
SS
S
VNI
GAFNLG
N
A
L
GA
AA
GG
A
V
I
S
-
A
GL
G
YS
F
V
PVM
GAI
V-
-
A
G
L
A
-
L
LLVF
M
S
ARK
QPETVCVANS
fig|749540.3.peg.4068
Escherichia coli MS 146-1
MKINYP
L
LALA
I
GAFG
I
GTTEF
S
PMGLL
PV
IA
RG
V
D
VSIPAAG
M
L
IS
A
YA
V
GV
M
VGAP
LMT
L
LL
S
HRA
RR
SA
LIFL
M
A
I
F
TL
GNVLS
A
IA
P
D
Y
MT
L
M
L
SRI
LTS
L
N
HGAFFGLG
S
V
VA
AS
V
V
P
K
H
K
Q
A
S
AVA
T
M
FM
G
L
TLAN
I
G
GVP
AA
T
W
LG
E
T
I
GWRM
S
FLA
T
A
GLG
VI
S
M
V
SL
FFS
LP
KGGA
G
A
R
P
E
V
-
K
KELAV
L
M
RP
Q
VL
S
A
L
L
T
TV
L
G
AG
A
M
FT
L
Y
T
YI
S
P
V
LQ
S
IT
H
A
T
PV
F
V
TA
M
L
V
LIG
V
G
FS
IGN
Y
L
G
GKL
AD
R
S
VN---G
T
LKG
FLL
L
L
MV
I
ML
A
IP
F
L
A
RN
E
FGAA
I
S
---
MVV
WGAA
T
FAV
VP
PLQM
R
V
M
RV
A
SE
A
PG
L
SS
S
VNI
GAFNLG
N
A
L
GA
AA
GG
A
V
I
S
-
A
GL
G
YS
F
V
PVM
GAI
V-
-
A
G
L
A
-
L
LLVF
M
S
ARK
QPETVCVANS
fig|749545.3.peg.2751
Escherichia coli MS 182-1
MKINYP
L
LALA
I
GAFG
I
GTTEF
S
PMGLL
PV
IA
RG
V
D
VSIPAAG
M
L
IS
A
YA
V
GV
M
VGAP
LMT
L
LL
S
HRA
RR
SA
LIFL
M
A
I
F
TL
GNVLS
A
IA
P
D
Y
MT
L
M
L
SRI
LTS
L
N
HGAFFGLG
S
V
VA
AS
V
V
P
K
H
K
Q
A
S
AVA
T
M
FM
G
L
TLAN
I
G
GVP
AA
T
W
LG
E
T
I
GWRM
S
FLA
T
A
GLG
VI
S
M
V
SL
FFS
LP
KGGA
G
A
R
P
E
V
-
K
KELAV
L
M
RP
Q
VL
S
A
L
L
T
TV
L
G
AG
A
M
FT
L
Y
T
YI
S
P
V
LQ
S
IT
H
A
T
PV
F
V
TA
M
L
V
LIG
V
G
FS
IGN
Y
L
G
GKL
AD
R
S
VN---G
T
LKG
FLL
L
L
MV
I
ML
A
IP
F
L
A
RN
E
FGAA
I
S
---
MVV
WGAA
T
FAV
VP
PLQM
R
V
M
RV
A
SE
A
PG
L
SS
S
VNI
GAFNLG
N
A
L
GA
AA
GG
A
V
I
S
-
A
GL
G
YS
F
V
PVM
GAI
V-
-
A
G
L
A
-
L
LLVF
M
S
ARK
QPETVCVANS
fig|749547.3.peg.3033
Escherichia coli MS 187-1
MKINYP
L
LALA
I
GAFG
I
GTTEF
S
PMGLL
PV
IA
RG
V
D
VSIPAAG
M
L
IS
A
YA
V
GV
M
VGAP
LMT
L
LL
S
HRA
RR
SA
LIFL
M
A
I
F
TL
GNVLS
A
IA
P
D
Y
MT
L
M
L
SRI
LTS
L
N
HGAFFGLG
S
V
VA
AS
V
V
P
K
H
K
Q
A
S
AVA
T
M
FM
G
L
TLAN
I
G
GVP
AA
T
W
LG
E
T
I
GWRM
S
FLA
T
A
GLG
VI
S
M
V
SL
FFS
LP
KGGA
G
A
R
P
E
V
-
K
KELAV
L
M
RP
Q
VL
S
A
L
L
T
TV
L
G
AG
A
M
FT
L
Y
T
YI
S
P
V
LQ
S
IT
H
A
T
PV
F
V
TA
M
L
V
LIG
V
G
FS
IGN
Y
L
G
GKL
AD
R
S
VN---G
T
LKG
FLL
L
L
MV
I
ML
A
IP
F
L
A
RN
E
FGAA
I
S
---
MVV
WGAA
T
FAV
VP
PLQM
R
V
M
RV
A
SE
A
PG
L
SS
S
VNI
GAFNLG
N
A
L
GA
AA
GG
A
V
I
S
-
A
GL
G
YS
F
V
PVM
GAI
V-
-
A
G
L
A
-
L
LLVF
M
S
ARK
QPETVCVANS
fig|749548.3.peg.3410
Escherichia coli MS 196-1
MKINYP
L
LALA
I
GAFG
I
GTTEF
S
PMGLL
PV
IA
RG
V
D
VSIPAAG
M
L
IS
A
YA
V
GV
M
VGAP
LMT
L
LL
S
HRA
RR
SA
LIFL
M
A
I
F
TL
GNVLS
A
IA
P
D
Y
MT
L
M
L
SRI
LTS
L
N
HGAFFGLG
S
V
VA
AS
V
V
P
K
H
K
Q
A
S
AVA
T
M
FM
G
L
TLAN
I
G
GVP
AA
T
W
LG
E
T
I
GWRM
S
FLA
T
A
GLG
VI
S
M
V
SL
FFS
LP
KGGA
G
A
R
P
E
V
-
K
KELAV
L
M
RP
Q
VL
S
A
L
L
T
TV
L
G
AG
A
M
FT
L
Y
T
YI
S
P
V
LQ
S
IT
H
A
T
PV
F
V
TA
M
L
V
LIG
V
G
FS
IGN
Y
L
G
GKL
AD
R
S
VN---G
T
LKG
FLL
L
L
MV
I
ML
A
IP
F
L
A
RN
E
FGAA
I
S
---
MVV
WGAA
T
FAV
VP
PLQM
R
V
M
RV
A
SE
A
PG
L
SS
S
VNI
GAFNLG
N
A
L
GA
AA
GG
A
V
I
S
-
A
GL
G
YS
F
V
PVM
GAI
V-
-
A
G
L
A
-
L
LLVF
M
S
ARK
QPETVCVANS
fig|749549.3.peg.5193
Escherichia coli MS 198-1
MKINYP
L
LALA
I
GAFG
I
GTTEF
S
PMGLL
PV
IA
RG
V
D
VSIPAAG
M
L
IS
A
YA
V
GV
M
VGAP
LMT
L
LL
S
HRA
RR
SA
LIFL
M
A
I
F
TL
GNVLS
A
IA
P
D
Y
MT
L
M
L
SRI
LTS
L
N
HGAFFGLG
S
V
VA
AS
V
V
P
K
H
K
Q
A
S
AVA
T
M
FM
G
L
TLAN
I
G
GVP
AA
T
W
LG
E
T
I
GWRM
S
FLA
T
A
GLG
VI
S
M
V
SL
FFS
LP
KGGA
G
A
R
P
E
V
-
K
KELAV
L
M
RP
Q
VL
S
A
L
L
T
TV
L
G
AG
A
M
FT
L
Y
T
YI
S
P
V
LQ
S
IT
H
A
T
PV
F
V
TA
M
L
V
LIG
V
G
FS
IGN
Y
L
G
GKL
AD
R
S
VN---G
T
LKG
FLL
L
L
MV
I
ML
A
IP
F
L
A
RN
E
FGAA
I
S
---
MVV
WGAA
T
FAV
VP
PLQM
R
V
M
RV
A
SE
A
PG
L
SS
S
VNI
GAFNLG
N
A
L
GA
AA
GG
A
V
I
S
-
A
GL
G
YS
F
V
PVM
GAI
V-
-
A
G
L
A
-
L
LLVF
M
S
ARK
QPETVCVANS
fig|749527.3.peg.3553
Escherichia coli MS 21-1
MKINYP
L
LALA
I
GAFG
I
GTTEF
S
PMGLL
PV
IA
RG
V
D
VSIPAAG
M
L
IS
A
YA
V
GV
M
VGAP
LMT
L
LL
S
HRA
RR
SA
LIFL
M
A
I
F
TL
GNVLS
A
IA
P
D
Y
MT
L
M
L
SRI
LTS
L
N
HGAFFGLG
S
V
VA
AS
V
V
P
K
H
K
Q
A
S
AVA
T
M
FM
G
L
TLAN
I
G
GVP
AA
T
W
LG
E
T
I
GWRM
S
FLA
T
A
GLG
VI
S
M
V
SL
FFS
LP
KGGA
G
A
R
P
E
V
-
K
KELAV
L
M
RP
Q
VL
S
A
L
L
T
TV
L
G
AG
A
M
FT
L
Y
T
YI
S
P
V
LQ
S
IT
H
A
T
PV
F
V
TA
M
L
V
LIG
V
G
FS
IGN
Y
L
G
GKL
AD
R
S
VN---G
T
LKG
FLL
L
L
MV
I
ML
A
IP
F
L
A
RN
E
FGAA
I
S
---
MVV
WGAA
T
FAV
VP
PLQM
R
V
M
RV
A
SE
A
PG
L
SS
S
VNI
GAFNLG
N
A
L
GA
AA
GG
A
V
I
S
-
A
GL
G
YS
F
V
PVM
GAI
V-
-
A
G
L
A
-
L
LLVF
M
S
ARK
QPETVCVANS
fig|749532.3.peg.1462
Escherichia coli MS 78-1
MKINYP
L
LALA
I
GAFG
I
GTTEF
S
PMGLL
PV
IA
RG
V
D
VSIPAAG
M
L
IS
A
YA
V
GV
M
VGAP
LMT
L
LL
S
HRA
RR
SA
LIFL
M
A
I
F
TL
GNVLS
A
IA
P
D
Y
MT
L
M
L
SRI
LTS
L
N
HGAFFGLG
S
V
VA
AS
V
V
P
K
H
K
Q
A
S
AVA
T
M
FM
G
L
TLAN
I
G
GVP
AA
T
W
LG
E
T
I
GWRM
S
FLA
T
A
GLG
VI
S
M
V
SL
FFS
LP
KGGA
G
A
R
P
E
V
-
K
KELAV
L
M
RP
Q
VL
S
A
L
L
T
TV
L
G
AG
A
M
FT
L
Y
T
YI
S
P
V
LQ
S
IT
H
A
T
PV
F
V
TA
M
L
V
LIG
V
G
FS
IGN
Y
L
G
GKL
AD
R
S
VN---G
T
LKG
FLL
L
L
MV
I
ML
A
IP
F
L
A
RN
E
FGAA
I
S
---
MVV
WGAA
T
FAV
VP
PLQM
R
V
M
RV
A
SE
A
PG
L
SS
S
VNI
GAFNLG
N
A
L
GA
AA
GG
A
V
I
S
-
A
GL
G
YS
F
V
PVM
GAI
V-
-
A
G
L
A
-
L
LLVF
M
S
ARK
QPETVCVANS
fig|749533.3.peg.2614
Escherichia coli MS 84-1
MKINYP
L
LALA
I
GAFG
I
GTTEF
S
PMGLL
PV
IA
RG
V
D
VSIPAAG
M
L
IS
A
YA
V
GV
M
VGAP
LMT
L
LL
S
HRA
RR
SA
LIFL
M
A
I
F
TL
GNVLS
A
IA
P
D
Y
MT
L
M
L
SRI
LTS
L
N
HGAFFGLG
S
V
VA
AS
V
V
P
K
H
K
Q
A
S
AVA
T
M
FM
G
L
TLAN
I
G
GVP
AA
T
W
LG
E
T
I
GWRM
S
FLA
T
A
GLG
VI
S
M
V
SL
FFS
LP
KGGA
G
A
R
P
E
V
-
K
KELAV
L
M
RP
Q
VL
S
A
L
L
T
TV
L
G
AG
A
M
FT
L
Y
T
YI
S
P
V
LQ
S
IT
H
A
T
PV
F
V
TA
M
L
V
LIG
V
G
FS
IGN
Y
L
G
GKL
AD
R
S
VN---G
T
LKG
FLL
L
L
MV
I
ML
A
IP
F
L
A
RN
E
FGAA
I
S
---
MVV
WGAA
T
FAV
VP
PLQM
R
V
M
RV
A
SE
A
PG
L
SS
S
VNI
GAFNLG
N
A
L
GA
AA
GG
A
V
I
S
-
A
GL
G
YS
F
V
PVM
GAI
V-
-
A
G
L
A
-
L
LLVF
M
S
ARK
QPETVCVANS
fig|585395.4.peg.1882
Escherichia coli O103:H2 str. 12009
MKINYP
L
LALA
I
GAFG
I
GTTEF
S
PMGLL
PV
IA
RG
V
D
VSIPAAG
M
L
IS
A
YA
V
GV
M
VGAP
LMT
L
LL
S
HRA
RR
SA
LIFL
M
A
I
F
TL
GNVLS
A
IA
P
D
Y
MT
L
M
L
SRI
LTS
L
N
HGAFFGLG
S
V
VA
AS
V
V
P
K
H
K
Q
A
S
AVA
T
M
FM
G
L
TLAN
I
G
GVP
AA
T
W
LG
E
T
I
GWRM
S
FLA
T
A
GLG
VI
S
M
V
SL
FFS
LP
KGGA
G
A
R
P
E
V
-
K
KELAV
L
M
RP
Q
VL
S
A
L
L
T
TV
L
G
AG
A
M
FT
L
Y
T
YI
S
P
V
LQ
S
IT
H
A
T
PV
F
V
TA
M
L
V
LIG
V
G
FS
IGN
Y
L
G
GKL
AD
R
S
VN---G
T
LKG
FLL
L
L
MV
I
ML
A
IP
F
L
A
RN
E
FGAA
I
S
---
MVV
WGAA
T
FAV
VP
PLQM
R
V
M
RV
A
SE
A
PG
L
SS
S
VNI
GAFNLG
N
A
L
GA
AA
GG
A
V
I
S
-
A
GL
G
YS
F
V
PVM
GAI
V-
-
A
G
L
A
-
L
LLVF
M
S
ARK
QPETVCVANS
fig|585396.4.peg.2209
Escherichia coli O111:H- str. 11128
MKINYP
L
LALA
I
GAFG
I
GTTEF
S
PMGLL
PV
IA
RG
V
D
VSIPAAG
M
L
IS
A
YA
V
GV
M
VGAP
LMT
L
LL
S
HRA
RR
SA
LIFL
M
A
I
F
TL
GNVLS
A
IA
P
D
Y
MT
L
M
L
SRI
LTS
L
N
HGAFFGLG
S
V
VA
AS
V
V
P
K
H
K
Q
A
S
AVA
T
M
FM
G
L
TLAN
I
G
GVP
AA
T
W
LG
E
T
I
GWRM
S
FLA
T
A
GLG
VI
S
M
V
SL
FFS
LP
KGGA
G
A
R
P
E
V
-
K
KELAV
L
M
RP
Q
VL
S
A
L
L
T
TV
L
G
AG
A
M
FT
L
Y
T
YI
S
P
V
LQ
S
IT
H
A
T
PV
F
V
TA
M
L
V
LIG
V
G
FS
IGN
Y
L
G
GKL
AD
R
S
VN---G
T
LKG
FLL
L
L
MV
I
ML
A
IP
F
L
A
RN
E
FGAA
I
S
---
MVV
WGAA
T
FAV
VP
PLQM
R
V
M
RV
A
SE
A
PG
L
SS
S
VNI
GAFNLG
N
A
L
GA
AA
GG
A
V
I
S
-
A
GL
G
YS
F
V
PVM
GAI
V-
-
A
G
L
A
-
L
LLVF
M
S
ARK
QPETVCVANS
fig|573235.3.peg.2424
Escherichia coli O26:H11 str. 11368
MKINYP
L
LALA
I
GAFG
I
GTTEF
S
PMGLL
PV
IA
RG
V
D
VSIPAAG
M
L
IS
A
YA
V
GV
M
VGAP
LMT
L
LL
S
HRA
RR
SA
LIFL
M
A
I
F
TL
GNVLS
A
IA
P
D
Y
MT
L
M
L
SRI
LTS
L
N
HGAFFGLG
S
V
VA
AS
V
V
P
K
H
K
Q
A
S
AVA
T
M
FM
G
L
TLAN
I
G
GVP
AA
T
W
LG
E
T
I
GWRM
S
FLA
T
A
GLG
VI
S
M
V
SL
FFS
LP
KGGA
G
A
R
P
E
V
-
K
KELAV
L
M
RP
Q
VL
S
A
L
L
T
TV
L
G
AG
A
M
FT
L
Y
T
YI
S
P
V
LQ
S
IT
H
A
T
PV
F
V
TA
M
L
V
LIG
V
G
FS
IGN
Y
L
G
GKL
AD
R
S
VN---G
T
LKG
FLL
L
L
MV
I
ML
A
IP
F
L
A
RN
E
FGAA
I
S
---
MVV
WGAA
T
FAV
VP
PLQM
R
V
M
RV
A
SE
A
PG
L
SS
S
VNI
GAFNLG
N
A
L
GA
AA
GG
A
V
I
S
-
A
GL
G
YS
F
V
PVM
GAI
V-
-
A
G
L
A
-
L
LLVF
M
S
ARK
QPETVCVANS
fig|701177.3.peg.2052
Escherichia coli O55:H7 str. CB9615
MKINYP
L
LALA
I
GAFG
I
GTTEF
S
PMGLL
PV
IA
RG
V
D
VSIPAAG
M
L
IS
A
YA
V
GV
M
VGAP
LMT
L
LL
S
HRA
RR
SA
LIFL
M
A
I
F
TL
GNVLS
A
IA
P
D
Y
MT
L
M
L
SRI
LTS
L
N
HGAFFGLG
S
V
VA
AS
V
V
P
K
H
K
Q
A
S
AVA
T
M
FM
G
L
TLAN
I
G
GVP
AA
T
W
LG
E
T
I
GWRM
S
FLA
T
A
GLG
VI
S
M
V
SL
FFS
LP
KGGA
G
A
R
P
E
V
-
K
KELAV
L
M
RP
Q
VL
S
A
L
L
T
TV
L
G
AG
A
M
FT
L
Y
T
YI
S
P
V
LQ
S
IT
H
A
T
PV
F
V
TA
M
L
V
LIG
V
G
FS
IGN
Y
L
G
GKL
AD
R
S
VN---G
T
LKG
FLL
L
L
MV
I
ML
A
IP
F
L
A
RN
E
FGAA
I
S
---
MVV
WGAA
T
FAV
VP
PLQM
R
V
M
RV
A
SE
A
PG
L
SS
S
VNI
GAFNLG
N
A
L
GA
AA
GG
A
V
I
S
-
A
GL
G
YS
F
V
PVM
GAI
V-
-
A
G
L
A
-
L
LLVF
M
S
ARK
QPETVCVANS
fig|409438.11.peg.1927
Escherichia coli SE11
MKINYP
L
LALA
I
GAFG
I
GTTEF
S
PMGLL
PV
IA
RG
V
D
VSIPAAG
M
L
IS
A
YA
V
GV
M
VGAP
LMT
L
LL
S
HRA
RR
SA
LIFL
M
A
I
F
TL
GNVLS
A
IA
P
D
Y
MT
L
M
L
SRI
LTS
L
N
HGAFFGLG
S
V
VA
AS
V
V
P
K
H
K
Q
A
S
AVA
T
M
FM
G
L
TLAN
I
G
GVP
AA
T
W
LG
E
T
I
GWRM
S
FLA
T
A
GLG
VI
S
M
V
SL
FFS
LP
KGGA
G
A
R
P
E
V
-
K
KELAV
L
M
RP
Q
VL
S
A
L
L
T
TV
L
G
AG
A
M
FT
L
Y
T
YI
S
P
V
LQ
S
IT
H
A
T
PV
F
V
TA
M
L
V
LIG
V
G
FS
IGN
Y
L
G
GKL
AD
R
S
VN---G
T
LKG
FLL
L
L
MV
I
ML
A
IP
F
L
A
RN
E
FGAA
I
S
---
MVV
WGAA
T
FAV
VP
PLQM
R
V
M
RV
A
SE
A
PG
L
SS
S
VNI
GAFNLG
N
A
L
GA
AA
GG
A
V
I
S
-
A
GL
G
YS
F
V
PVM
GAI
V-
-
A
G
L
A
-
L
LLVF
M
S
ARK
QPETVCVANS
fig|439855.10.peg.1699
Escherichia coli SMS-3-5
MKINYP
L
LALA
I
GAFG
I
GTTEF
S
PMGLL
PV
IA
RG
V
D
VSIPAAG
M
L
IS
A
YA
V
GV
M
VGAP
LMT
L
LL
S
HRA
RR
SA
LIFL
M
A
I
F
TL
GNVLS
A
IA
P
D
Y
MT
L
M
L
SRI
LTS
L
N
HGAFFGLG
S
V
VA
AS
V
V
P
K
H
K
Q
A
S
AVA
T
M
FM
G
L
TLAN
I
G
GVP
AA
T
W
LG
E
T
I
GWRM
S
FLA
T
A
GLG
VI
S
M
V
SL
FFS
LP
KGGA
G
A
R
P
E
V
-
K
KELAV
L
M
RP
Q
VL
S
A
L
L
T
TV
L
G
AG
A
M
FT
L
Y
T
YI
S
P
V
LQ
S
IT
H
A
T
PV
F
V
TA
M
L
V
LIG
V
G
FS
IGN
Y
L
G
GKL
AD
R
S
VN---G
T
LKG
FLL
L
L
MV
I
ML
A
IP
F
L
A
RN
E
FGAA
I
S
---
MVV
WGAA
T
FAV
VP
PLQM
R
V
M
RV
A
SE
A
PG
L
SS
S
VNI
GAFNLG
N
A
L
GA
AA
GG
A
V
I
S
-
A
GL
G
YS
F
V
PVM
GAI
V-
-
A
G
L
A
-
L
LLVF
M
S
ARK
QPETVCVANS
fig|656443.3.peg.2319
Escherichia coli TA271
MKINYP
L
LALA
I
GAFG
I
GTTEF
S
PMGLL
PV
IA
RG
V
D
VSIPAAG
M
L
IS
A
YA
V
GV
M
VGAP
LMT
L
LL
S
HRA
RR
SA
LIFL
M
A
I
F
TL
GNVLS
A
IA
P
D
Y
MT
L
M
L
SRI
LTS
L
N
HGAFFGLG
S
V
VA
AS
V
V
P
K
H
K
Q
A
S
AVA
T
M
FM
G
L
TLAN
I
G
GVP
AA
T
W
LG
E
T
I
GWRM
S
FLA
T
A
GLG
VI
S
M
V
SL
FFS
LP
KGGA
G
A
R
P
E
V
-
K
KELAV
L
M
RP
Q
VL
S
A
L
L
T
TV
L
G
AG
A
M
FT
L
Y
T
YI
S
P
V
LQ
S
IT
H
A
T
PV
F
V
TA
M
L
V
LIG
V
G
FS
IGN
Y
L
G
GKL
AD
R
S
VN---G
T
LKG
FLL
L
L
MV
I
ML
A
IP
F
L
A
RN
E
FGAA
I
S
---
MVV
WGAA
T
FAV
VP
PLQM
R
V
M
RV
A
SE
A
PG
L
SS
S
VNI
GAFNLG
N
A
L
GA
AA
GG
A
V
I
S
-
A
GL
G
YS
F
V
PVM
GAI
V-
-
A
G
L
A
-
L
LLVF
M
S
ARK
QPETVCVANS
fig|585056.7.peg.2133
Escherichia coli UMN026
MKINYP
L
LALA
I
GAFG
I
GTTEF
S
PMGLL
PV
IA
RG
V
D
VSIPAAG
M
L
IS
A
YA
V
GV
M
VGAP
LMT
L
LL
S
HRA
RR
SA
LIFL
M
A
I
F
TL
GNVLS
A
IA
P
D
Y
MT
L
M
L
SRI
LTS
L
N
HGAFFGLG
S
V
VA
AS
V
V
P
K
H
K
Q
A
S
AVA
T
M
FM
G
L
TLAN
I
G
GVP
AA
T
W
LG
E
T
I
GWRM
S
FLA
T
A
GLG
VI
S
M
V
SL
FFS
LP
KGGA
G
A
R
P
E
V
-
K
KELAV
L
M
RP
Q
VL
S
A
L
L
T
TV
L
G
AG
A
M
FT
L
Y
T
YI
S
P
V
LQ
S
IT
H
A
T
PV
F
V
TA
M
L
V
LIG
V
G
FS
IGN
Y
L
G
GKL
AD
R
S
VN---G
T
LKG
FLL
L
L
MV
I
ML
A
IP
F
L
A
RN
E
FGAA
I
S
---
MVV
WGAA
T
FAV
VP
PLQM
R
V
M
RV
A
SE
A
PG
L
SS
S
VNI
GAFNLG
N
A
L
GA
AA
GG
A
V
I
S
-
A
GL
G
YS
F
V
PVM
GAI
V-
-
A
G
L
A
-
L
LLVF
M
S
ARK
QPETVCVANS
fig|566546.3.peg.989
Escherichia coli W
MKINYP
L
LALA
I
GAFG
I
GTTEF
S
PMGLL
PV
IA
RG
V
D
VSIPAAG
M
L
IS
A
YA
V
GV
M
VGAP
LMT
L
LL
S
HRA
RR
SA
LIFL
M
A
I
F
TL
GNVLS
A
IA
P
D
Y
MT
L
M
L
SRI
LTS
L
N
HGAFFGLG
S
V
VA
AS
V
V
P
K
H
K
Q
A
S
AVA
T
M
FM
G
L
TLAN
I
G
GVP
AA
T
W
LG
E
T
I
GWRM
S
FLA
T
A
GLG
VI
S
M
V
SL
FFS
LP
KGGA
G
A
R
P
E
V
-
K
KELAV
L
M
RP
Q
VL
S
A
L
L
T
TV
L
G
AG
A
M
FT
L
Y
T
YI
S
P
V
LQ
S
IT
H
A
T
PV
F
V
TA
M
L
V
LIG
V
G
FS
IGN
Y
L
G
GKL
AD
R
S
VN---G
T
LKG
FLL
L
L
MV
I
ML
A
IP
F
L
A
RN
E
FGAA
I
S
---
MVV
WGAA
T
FAV
VP
PLQM
R
V
M
RV
A
SE
A
PG
L
SS
S
VNI
GAFNLG
N
A
L
GA
AA
GG
A
V
I
S
-
A
GL
G
YS
F
V
PVM
GAI
V-
-
A
G
L
A
-
L
LLVF
M
S
ARK
QPETVCVANS
fig|566546.4.peg.1812
Escherichia coli W
MKINYP
L
LALA
I
GAFG
I
GTTEF
S
PMGLL
PV
IA
RG
V
D
VSIPAAG
M
L
IS
A
YA
V
GV
M
VGAP
LMT
L
LL
S
HRA
RR
SA
LIFL
M
A
I
F
TL
GNVLS
A
IA
P
D
Y
MT
L
M
L
SRI
LTS
L
N
HGAFFGLG
S
V
VA
AS
V
V
P
K
H
K
Q
A
S
AVA
T
M
FM
G
L
TLAN
I
G
GVP
AA
T
W
LG
E
T
I
GWRM
S
FLA
T
A
GLG
VI
S
M
V
SL
FFS
LP
KGGA
G
A
R
P
E
V
-
K
KELAV
L
M
RP
Q
VL
S
A
L
L
T
TV
L
G
AG
A
M
FT
L
Y
T
YI
S
P
V
LQ
S
IT
H
A
T
PV
F
V
TA
M
L
V
LIG
V
G
FS
IGN
Y
L
G
GKL
AD
R
S
VN---G
T
LKG
FLL
L
L
MV
I
ML
A
IP
F
L
A
RN
E
FGAA
I
S
---
MVV
WGAA
T
FAV
VP
PLQM
R
V
M
RV
A
SE
A
PG
L
SS
S
VNI
GAFNLG
N
A
L
GA
AA
GG
A
V
I
S
-
A
GL
G
YS
F
V
PVM
GAI
V-
-
A
G
L
A
-
L
LLVF
M
S
ARK
QPETVCVANS
fig|316407.3.peg.1615
Escherichia coli W3110
MKINYP
L
LALA
I
GAFG
I
GTTEF
S
PMGLL
PV
IA
RG
V
D
VSIPAAG
M
L
IS
A
YA
V
GV
M
VGAP
LMT
L
LL
S
HRA
RR
SA
LIFL
M
A
I
F
TL
GNVLS
A
IA
P
D
Y
MT
L
M
L
SRI
LTS
L
N
HGAFFGLG
S
V
VA
AS
V
V
P
K
H
K
Q
A
S
AVA
T
M
FM
G
L
TLAN
I
G
GVP
AA
T
W
LG
E
T
I
GWRM
S
FLA
T
A
GLG
VI
S
M
V
SL
FFS
LP
KGGA
G
A
R
P
E
V
-
K
KELAV
L
M
RP
Q
VL
S
A
L
L
T
TV
L
G
AG
A
M
FT
L
Y
T
YI
S
P
V
LQ
S
IT
H
A
T
PV
F
V
TA
M
L
V
LIG
V
G
FS
IGN
Y
L
G
GKL
AD
R
S
VN---G
T
LKG
FLL
L
L
MV
I
ML
A
IP
F
L
A
RN
E
FGAA
I
S
---
MVV
WGAA
T
FAV
VP
PLQM
R
V
M
RV
A
SE
A
PG
L
SS
S
VNI
GAFNLG
N
A
L
GA
AA
GG
A
V
I
S
-
A
GL
G
YS
F
V
PVM
GAI
V-
-
A
G
L
A
-
L
LLVF
M
S
ARK
QPETVCVANS
fig|316385.5.peg.1770
Escherichia coli str. K-12 substr. DH10B
MKINYP
L
LALA
I
GAFG
I
GTTEF
S
PMGLL
PV
IA
RG
V
D
VSIPAAG
M
L
IS
A
YA
V
GV
M
VGAP
LMT
L
LL
S
HRA
RR
SA
LIFL
M
A
I
F
TL
GNVLS
A
IA
P
D
Y
MT
L
M
L
SRI
LTS
L
N
HGAFFGLG
S
V
VA
AS
V
V
P
K
H
K
Q
A
S
AVA
T
M
FM
G
L
TLAN
I
G
GVP
AA
T
W
LG
E
T
I
GWRM
S
FLA
T
A
GLG
VI
S
M
V
SL
FFS
LP
KGGA
G
A
R
P
E
V
-
K
KELAV
L
M
RP
Q
VL
S
A
L
L
T
TV
L
G
AG
A
M
FT
L
Y
T
YI
S
P
V
LQ
S
IT
H
A
T
PV
F
V
TA
M
L
V
LIG
V
G
FS
IGN
Y
L
G
GKL
AD
R
S
VN---G
T
LKG
FLL
L
L
MV
I
ML
A
IP
F
L
A
RN
E
FGAA
I
S
---
MVV
WGAA
T
FAV
VP
PLQM
R
V
M
RV
A
SE
A
PG
L
SS
S
VNI
GAFNLG
N
A
L
GA
AA
GG
A
V
I
S
-
A
GL
G
YS
F
V
PVM
GAI
V-
-
A
G
L
A
-
L
LLVF
M
S
ARK
QPETVCVANS
fig|316385.7.peg.1815
Escherichia coli str. K-12 substr. DH10B
MKINYP
L
LALA
I
GAFG
I
GTTEF
S
PMGLL
PV
IA
RG
V
D
VSIPAAG
M
L
IS
A
YA
V
GV
M
VGAP
LMT
L
LL
S
HRA
RR
SA
LIFL
M
A
I
F
TL
GNVLS
A
IA
P
D
Y
MT
L
M
L
SRI
LTS
L
N
HGAFFGLG
S
V
VA
AS
V
V
P
K
H
K
Q
A
S
AVA
T
M
FM
G
L
TLAN
I
G
GVP
AA
T
W
LG
E
T
I
GWRM
S
FLA
T
A
GLG
VI
S
M
V
SL
FFS
LP
KGGA
G
A
R
P
E
V
-
K
KELAV
L
M
RP
Q
VL
S
A
L
L
T
TV
L
G
AG
A
M
FT
L
Y
T
YI
S
P
V
LQ
S
IT
H
A
T
PV
F
V
TA
M
L
V
LIG
V
G
FS
IGN
Y
L
G
GKL
AD
R
S
VN---G
T
LKG
FLL
L
L
MV
I
ML
A
IP
F
L
A
RN
E
FGAA
I
S
---
MVV
WGAA
T
FAV
VP
PLQM
R
V
M
RV
A
SE
A
PG
L
SS
S
VNI
GAFNLG
N
A
L
GA
AA
GG
A
V
I
S
-
A
GL
G
YS
F
V
PVM
GAI
V-
-
A
G
L
A
-
L
LLVF
M
S
ARK
QPETVCVANS
fig|511145.12.peg.1729
Escherichia coli str. K-12 substr. MG1655
MKINYP
L
LALA
I
GAFG
I
GTTEF
S
PMGLL
PV
IA
RG
V
D
VSIPAAG
M
L
IS
A
YA
V
GV
M
VGAP
LMT
L
LL
S
HRA
RR
SA
LIFL
M
A
I
F
TL
GNVLS
A
IA
P
D
Y
MT
L
M
L
SRI
LTS
L
N
HGAFFGLG
S
V
VA
AS
V
V
P
K
H
K
Q
A
S
AVA
T
M
FM
G
L
TLAN
I
G
GVP
AA
T
W
LG
E
T
I
GWRM
S
FLA
T
A
GLG
VI
S
M
V
SL
FFS
LP
KGGA
G
A
R
P
E
V
-
K
KELAV
L
M
RP
Q
VL
S
A
L
L
T
TV
L
G
AG
A
M
FT
L
Y
T
YI
S
P
V
LQ
S
IT
H
A
T
PV
F
V
TA
M
L
V
LIG
V
G
FS
IGN
Y
L
G
GKL
AD
R
S
VN---G
T
LKG
FLL
L
L
MV
I
ML
A
IP
F
L
A
RN
E
FGAA
I
S
---
MVV
WGAA
T
FAV
VP
PLQM
R
V
M
RV
A
SE
A
PG
L
SS
S
VNI
GAFNLG
N
A
L
GA
AA
GG
A
V
I
S
-
A
GL
G
YS
F
V
PVM
GAI
V-
-
A
G
L
A
-
L
LLVF
M
S
ARK
QPETVCVANS
fig|511145.6.peg.1713
Escherichia coli str. K-12 substr. MG1655
MKINYP
L
LALA
I
GAFG
I
GTTEF
S
PMGLL
PV
IA
RG
V
D
VSIPAAG
M
L
IS
A
YA
V
GV
M
VGAP
LMT
L
LL
S
HRA
RR
SA
LIFL
M
A
I
F
TL
GNVLS
A
IA
P
D
Y
MT
L
M
L
SRI
LTS
L
N
HGAFFGLG
S
V
VA
AS
V
V
P
K
H
K
Q
A
S
AVA
T
M
FM
G
L
TLAN
I
G
GVP
AA
T
W
LG
E
T
I
GWRM
S
FLA
T
A
GLG
VI
S
M
V
SL
FFS
LP
KGGA
G
A
R
P
E
V
-
K
KELAV
L
M
RP
Q
VL
S
A
L
L
T
TV
L
G
AG
A
M
FT
L
Y
T
YI
S
P
V
LQ
S
IT
H
A
T
PV
F
V
TA
M
L
V
LIG
V
G
FS
IGN
Y
L
G
GKL
AD
R
S
VN---G
T
LKG
FLL
L
L
MV
I
ML
A
IP
F
L
A
RN
E
FGAA
I
S
---
MVV
WGAA
T
FAV
VP
PLQM
R
V
M
RV
A
SE
A
PG
L
SS
S
VNI
GAFNLG
N
A
L
GA
AA
GG
A
V
I
S
-
A
GL
G
YS
F
V
PVM
GAI
V-
-
A
G
L
A
-
L
LLVF
M
S
ARK
QPETVCVANS
fig|585057.4.peg.1464
Escherichia coli IAI39
MKINYP
L
LALA
I
GAFG
I
GTTEF
S
PMGLL
PV
IA
RG
V
D
VSIPAAG
M
L
IS
A
YA
V
GV
M
VGAP
LMT
L
LL
S
HRA
RR
SA
LIFL
M
A
I
F
TL
GNVLS
A
IA
P
D
Y
MT
L
M
L
SRI
LTS
L
N
HGAFFGLG
S
V
VA
AS
V
V
P
K
H
K
Q
A
S
AVA
T
M
FM
G
L
TLAN
I
G
GVP
AA
T
W
LG
E
T
I
GWRM
S
FLA
T
A
GLG
VI
S
M
V
SL
FFS
LP
KGGA
G
A
R
P
E
V
-
K
KELAV
L
M
RP
Q
VL
S
A
L
L
T
TV
L
G
AG
A
M
FT
L
Y
T
YI
S
P
V
V
Q
S
IT
H
A
T
PV
F
V
TA
M
L
V
LIG
V
G
FS
IGN
Y
L
G
GKL
AD
R
S
VN---G
T
LKG
FLL
L
L
MV
I
ML
A
IP
F
L
A
RN
E
FGAA
I
S
---
MVV
WGAA
T
FAV
VP
PLQM
R
V
M
RV
A
SE
A
PG
L
SS
S
VNI
GAFNLG
N
A
L
GA
AA
GG
A
V
I
S
-
A
GL
G
YS
F
V
PVM
GAI
V-
-
A
G
L
A
-
L
LLVF
M
S
ARK
QPETVCVANS
fig|585057.6.peg.1463
Escherichia coli IAI39
MKINYP
L
LALA
I
GAFG
I
GTTEF
S
PMGLL
PV
IA
RG
V
D
VSIPAAG
M
L
IS
A
YA
V
GV
M
VGAP
LMT
L
LL
S
HRA
RR
SA
LIFL
M
A
I
F
TL
GNVLS
A
IA
P
D
Y
MT
L
M
L
SRI
LTS
L
N
HGAFFGLG
S
V
VA
AS
V
V
P
K
H
K
Q
A
S
AVA
T
M
FM
G
L
TLAN
I
G
GVP
AA
T
W
LG
E
T
I
GWRM
S
FLA
T
A
GLG
VI
S
M
V
SL
FFS
LP
KGGA
G
A
R
P
E
V
-
K
KELAV
L
M
RP
Q
VL
S
A
L
L
T
TV
L
G
AG
A
M
FT
L
Y
T
YI
S
P
V
V
Q
S
IT
H
A
T
PV
F
V
TA
M
L
V
LIG
V
G
FS
IGN
Y
L
G
GKL
AD
R
S
VN---G
T
LKG
FLL
L
L
MV
I
ML
A
IP
F
L
A
RN
E
FGAA
I
S
---
MVV
WGAA
T
FAV
VP
PLQM
R
V
M
RV
A
SE
A
PG
L
SS
S
VNI
GAFNLG
N
A
L
GA
AA
GG
A
V
I
S
-
A
GL
G
YS
F
V
PVM
GAI
V-
-
A
G
L
A
-
L
LLVF
M
S
ARK
QPETVCVANS
fig|656437.3.peg.1878
Escherichia coli TA143
MKINYP
L
LALA
I
GAFG
I
GTTEF
S
PMGLL
PV
IA
RG
V
D
VSIPAAG
M
L
T
S
A
YA
V
GV
M
VGAP
LMT
L
LL
S
HRA
RR
SA
LIFL
M
A
I
F
TL
GNVLS
A
IA
P
D
Y
MT
L
M
L
SRI
LTS
L
N
HGAFFGLG
S
V
VA
AS
V
V
P
K
H
K
Q
A
S
AVA
T
M
FM
G
L
TLAN
I
G
GVP
AA
T
W
LG
E
T
I
GWRM
S
FLA
T
A
GLG
VI
S
M
V
SL
FFS
LP
KGGA
G
A
R
P
E
V
-
K
KELAV
L
M
RP
Q
VL
S
A
L
L
T
TV
L
G
AG
A
M
FT
L
Y
T
YI
S
P
V
LQ
S
IT
H
A
T
PV
F
V
TA
M
L
V
LIG
V
G
FS
IGN
Y
L
G
GKL
AD
R
S
VN---G
T
LKG
FLL
L
L
MV
I
ML
A
IP
F
L
A
RN
E
FGAA
I
S
---
MVV
WGAA
T
FAV
VP
PLQM
R
V
M
RV
A
SE
A
PG
L
SS
S
VNI
GAFNLG
N
A
L
GA
AA
GG
A
V
I
S
-
A
GL
G
YS
F
V
PVM
GAI
V-
-
A
G
L
A
-
L
LLVF
M
S
ARK
QPETVCVANS
fig|216593.1.peg.432
Escherichia coli E2348/69
MKINYP
L
LALA
I
GAFG
I
GTTEF
S
PMGLL
PV
IA
RG
V
D
VSIPAAG
M
L
IS
A
YA
V
GV
M
VGAP
LMT
L
LL
S
HRA
RR
SA
LIFL
M
A
I
F
TL
GNVLS
A
IA
P
D
Y
MT
L
M
L
SRI
LTS
L
N
HGAFFGLG
S
V
VA
AS
V
V
P
K
H
K
Q
A
S
AVA
T
M
FM
G
L
TLAN
I
G
GVP
AA
T
W
LG
E
T
I
GWRM
S
FLA
T
A
GLG
VI
S
M
V
SL
FFS
LP
KGGA
G
A
R
P
E
V
-
K
KELAV
L
M
RP
Q
VL
S
A
L
L
T
TV
L
G
AG
A
M
FT
L
Y
T
YI
S
P
V
LQ
S
IT
H
V
T
PV
F
V
TA
M
L
V
LIG
V
G
FS
IGN
Y
L
G
GKL
AD
R
S
VN---G
T
LKG
FLL
L
L
MV
I
ML
A
IP
F
L
A
RN
E
FGAA
I
S
---
MVV
WGAA
T
FAV
VP
PLQM
R
V
M
RV
A
SE
A
PG
L
SS
S
VNI
GAFNLG
N
A
L
GA
AA
GG
A
V
I
S
-
A
GL
G
YS
F
V
PVM
GAI
V-
-
A
G
L
A
-
L
LLVF
M
S
VRK
QPETVCVANS
fig|574521.7.peg.1783
Escherichia coli O127:H6 str. E2348/69
MKINYP
L
LALA
I
GAFG
I
GTTEF
S
PMGLL
PV
IA
RG
V
D
VSIPAAG
M
L
IS
A
YA
V
GV
M
VGAP
LMT
L
LL
S
HRA
RR
SA
LIFL
M
A
I
F
TL
GNVLS
A
IA
P
D
Y
MT
L
M
L
SRI
LTS
L
N
HGAFFGLG
S
V
VA
AS
V
V
P
K
H
K
Q
A
S
AVA
T
M
FM
G
L
TLAN
I
G
GVP
AA
T
W
LG
E
T
I
GWRM
S
FLA
T
A
GLG
VI
S
M
V
SL
FFS
LP
KGGA
G
A
R
P
E
V
-
K
KELAV
L
M
RP
Q
VL
S
A
L
L
T
TV
L
G
AG
A
M
FT
L
Y
T
YI
S
P
V
LQ
S
IT
H
V
T
PV
F
V
TA
M
L
V
LIG
V
G
FS
IGN
Y
L
G
GKL
AD
R
S
VN---G
T
LKG
FLL
L
L
MV
I
ML
A
IP
F
L
A
RN
E
FGAA
I
S
---
MVV
WGAA
T
FAV
VP
PLQM
R
V
M
RV
A
SE
A
PG
L
SS
S
VNI
GAFNLG
N
A
L
GA
AA
GG
A
V
I
S
-
A
GL
G
YS
F
V
PVM
GAI
V-
-
A
G
L
A
-
L
LLVF
M
S
VRK
QPETVCVANS
fig|344610.3.peg.3125
Escherichia coli 53638
MKINYP
L
LALA
I
GAFG
I
GTTEF
S
PMGLL
PV
IA
RG
V
D
VSIPAAG
M
L
IS
A
YA
V
GV
M
VGAP
LMT
L
LL
S
HRA
RR
SA
LIFL
M
A
I
F
TL
GNVLS
A
IA
P
D
Y
MT
L
M
L
SRI
LTS
L
N
HGAFFGLG
S
V
VA
AS
V
V
P
K
H
K
Q
A
S
AVA
T
M
FM
G
L
TLAN
I
G
GVP
AA
T
W
LG
E
T
I
GWRM
S
FLA
T
A
GLG
VI
S
M
V
SL
FFS
LP
KGGA
G
A
R
P
E
V
-
K
KELAV
L
M
RP
Q
VL
S
A
L
L
T
TV
L
G
AG
A
M
FT
L
Y
T
YI
S
P
V
LQ
S
I
A
H
A
T
PV
F
V
TA
M
L
V
LIG
V
G
FS
IGN
Y
L
G
GKL
AD
R
S
VN---G
T
LKG
FLL
L
L
MV
I
ML
A
IP
F
L
A
RN
E
FGAA
I
S
---
MVV
WGAA
T
FAV
VP
PLQM
R
V
M
RV
A
SE
A
PG
L
SS
S
VNI
GAFNLG
N
A
L
GA
AA
GG
A
V
I
S
-
A
GL
G
YS
F
V
PVM
GAI
V-
-
A
G
L
A
-
L
LLVF
M
S
ARK
QPETVCVANS
fig|344610.7.peg.5308
Escherichia coli 53638
MKINYP
L
LALA
I
GAFG
I
GTTEF
S
PMGLL
PV
IA
RG
V
D
VSIPAAG
M
L
IS
A
YA
V
GV
M
VGAP
LMT
L
LL
S
HRA
RR
SA
LIFL
M
A
I
F
TL
GNVLS
A
IA
P
D
Y
MT
L
M
L
SRI
LTS
L
N
HGAFFGLG
S
V
VA
AS
V
V
P
K
H
K
Q
A
S
AVA
T
M
FM
G
L
TLAN
I
G
GVP
AA
T
W
LG
E
T
I
GWRM
S
FLA
T
A
GLG
VI
S
M
V
SL
FFS
LP
KGGA
G
A
R
P
E
V
-
K
KELAV
L
M
RP
Q
VL
S
A
L
L
T
TV
L
G
AG
A
M
FT
L
Y
T
YI
S
P
V
LQ
S
I
A
H
A
T
PV
F
V
TA
M
L
V
LIG
V
G
FS
IGN
Y
L
G
GKL
AD
R
S
VN---G
T
LKG
FLL
L
L
MV
I
ML
A
IP
F
L
A
RN
E
FGAA
I
S
---
MVV
WGAA
T
FAV
VP
PLQM
R
V
M
RV
A
SE
A
PG
L
SS
S
VNI
GAFNLG
N
A
L
GA
AA
GG
A
V
I
S
-
A
GL
G
YS
F
V
PVM
GAI
V-
-
A
G
L
A
-
L
LLVF
M
S
ARK
QPETVCVANS
fig|340184.3.peg.942
Escherichia coli B7A
MKINYP
L
LALA
I
GAFG
I
GTTEF
S
PMGLL
PV
IA
RG
V
D
VSIPAAG
M
L
IS
A
YA
V
GV
M
VGAP
LMT
L
LL
S
HRA
RR
SA
LIFL
M
A
I
F
TL
GNVLS
A
IA
P
D
Y
MT
L
M
L
SRI
LTS
L
N
HGAFFGLG
S
V
VA
AS
V
V
P
K
H
K
Q
A
S
AVA
T
M
FM
G
L
TLAN
I
G
GVP
AA
T
W
LG
E
T
I
GWRM
S
FLA
T
A
GLG
VI
S
M
V
SL
FFS
LP
KGGA
G
A
R
P
E
V
-
K
KELAV
L
M
RP
Q
VL
S
A
L
L
T
TV
L
G
AG
A
M
FT
L
Y
T
YI
S
P
V
LQ
S
I
A
H
A
T
PV
F
V
TA
M
L
V
LIG
V
G
FS
IGN
Y
L
G
GKL
AD
R
S
VN---G
T
LKG
FLL
L
L
MV
I
ML
A
IP
F
L
A
RN
E
FGAA
I
S
---
MVV
WGAA
T
FAV
VP
PLQM
R
V
M
RV
A
SE
A
PG
L
SS
S
VNI
GAFNLG
N
A
L
GA
AA
GG
A
V
I
S
-
A
GL
G
YS
F
V
PVM
GAI
V-
-
A
G
L
A
-
L
LLVF
M
S
ARK
QPETVCVANS
fig|340184.6.peg.977
Escherichia coli B7A
MKINYP
L
LALA
I
GAFG
I
GTTEF
S
PMGLL
PV
IA
RG
V
D
VSIPAAG
M
L
IS
A
YA
V
GV
M
VGAP
LMT
L
LL
S
HRA
RR
SA
LIFL
M
A
I
F
TL
GNVLS
A
IA
P
D
Y
MT
L
M
L
SRI
LTS
L
N
HGAFFGLG
S
V
VA
AS
V
V
P
K
H
K
Q
A
S
AVA
T
M
FM
G
L
TLAN
I
G
GVP
AA
T
W
LG
E
T
I
GWRM
S
FLA
T
A
GLG
VI
S
M
V
SL
FFS
LP
KGGA
G
A
R
P
E
V
-
K
KELAV
L
M
RP
Q
VL
S
A
L
L
T
TV
L
G
AG
A
M
FT
L
Y
T
YI
S
P
V
LQ
S
I
A
H
A
T
PV
F
V
TA
M
L
V
LIG
V
G
FS
IGN
Y
L
G
GKL
AD
R
S
VN---G
T
LKG
FLL
L
L
MV
I
ML
A
IP
F
L
A
RN
E
FGAA
I
S
---
MVV
WGAA
T
FAV
VP
PLQM
R
V
M
RV
A
SE
A
PG
L
SS
S
VNI
GAFNLG
N
A
L
GA
AA
GG
A
V
I
S
-
A
GL
G
YS
F
V
PVM
GAI
V-
-
A
G
L
A
-
L
LLVF
M
S
ARK
QPETVCVANS
fig|656393.3.peg.2452
Escherichia coli H299
MKINYP
L
LALA
I
GAFG
I
GTTEF
S
PMGLL
PV
IA
RG
V
D
VSIPAAG
M
L
IS
A
YA
V
GV
M
VGAP
LMT
L
LL
S
HRA
RR
SA
LIFL
M
A
I
F
TL
GNVLS
A
IA
P
D
Y
MT
L
M
L
SRI
LTS
L
N
HGAFFGLG
S
V
VA
AS
V
V
P
K
H
K
Q
A
S
AVA
T
M
FM
G
L
TLAN
I
G
GVP
AA
T
W
LG
E
T
I
GWRM
S
FLA
T
A
GLG
VI
S
M
V
SL
FFS
LP
KGGA
G
A
R
P
E
V
-
K
KELAV
L
M
RP
Q
VL
S
A
L
L
T
TV
L
G
AG
A
M
FT
L
Y
T
YI
S
P
V
LQ
S
IT
H
A
T
PV
F
V
TA
M
L
V
LIG
V
G
FS
IGN
Y
L
G
GKL
AD
R
S
VN---G
T
LKG
FLL
L
L
MV
I
ML
A
IP
F
L
A
RN
E
FGAA
I
S
---
MVV
WGAA
T
FAV
VP
PLQM
R
V
M
RV
A
SE
A
PG
L
SS
S
VNI
GAFNLG
N
A
L
GA
AA
GG
A
V
I
S
-
A
GL
G
YS
F
V
PVM
GAI
V-
-
A
G
L
A
-
L
LLVF
M
S
ARK
QPE
A
VCVANS
fig|679204.3.peg.579
Escherichia coli MS 145-7
MKINYP
L
LALA
I
GAFG
I
GTTEF
S
PMGLL
PV
IA
RG
V
D
VSIPAAG
M
L
IS
A
YA
V
GV
M
VGAP
LMT
L
LL
S
HRA
RR
SA
LIFL
M
A
I
F
TL
GNVLS
A
IA
P
D
Y
MT
L
M
L
SRI
LTS
L
N
HGAFFGLG
S
V
VA
AS
V
V
P
K
H
K
Q
A
S
AVA
T
M
FM
G
L
TLAN
I
G
GVP
AA
T
W
LG
E
T
I
GWRM
S
FLA
T
A
GLG
VI
S
M
V
SL
FFS
LP
KGGA
G
A
R
P
E
V
-
K
KELAV
L
M
RP
Q
VL
S
A
L
L
T
TV
L
G
AG
A
M
FT
L
Y
T
YI
S
P
V
LQ
S
I
A
H
A
T
PV
F
V
TA
M
L
V
LIG
V
G
FS
IGN
Y
L
G
GKL
AD
R
S
VN---G
T
LKG
FLL
L
L
MV
I
ML
A
IP
F
L
A
RN
E
FGAA
I
S
---
MVV
WGAA
T
FAV
VP
PLQM
R
V
M
RV
A
SE
A
PG
L
SS
S
VNI
GAFNLG
N
A
L
GA
AA
GG
A
V
I
S
-
A
GL
G
YS
F
V
PVM
GAI
V-
-
A
G
L
A
-
L
LLVF
M
S
ARK
QPETVCVANS
fig|656444.3.peg.2558
Escherichia coli TA280
MKINYP
L
LALA
I
GAFG
I
GTTEF
S
PMGLL
PV
IA
RG
V
D
VSIPAAG
M
L
IS
A
YA
V
GV
M
VGAP
LMT
L
LL
S
HRA
RR
SA
LIFL
M
A
I
F
TL
GNVLS
A
IA
P
D
Y
MT
L
M
L
SRI
LTS
L
N
HGAFFGLG
S
V
VA
AS
V
V
P
K
H
K
Q
A
S
AVA
T
M
FM
G
L
TLAN
I
G
GVP
AA
T
W
LG
E
T
I
GWRM
S
FLA
T
A
GLG
VI
S
M
V
SL
FFS
LP
KGGA
G
A
R
P
E
V
-
K
KELAV
L
M
RP
Q
VL
S
A
L
L
T
TV
L
G
AG
A
M
FT
L
Y
T
YI
S
P
V
LQ
S
IT
H
A
T
PV
F
V
TA
M
L
V
LIG
V
G
FS
IGN
Y
L
G
GKL
AD
R
S
VN---G
T
LKG
FLL
L
L
MV
I
ML
A
IP
F
L
A
RN
E
FGAA
I
S
---
MVV
WGAA
T
FAV
VP
PLQM
R
V
M
RV
A
SE
A
PG
L
SS
S
VNI
GAFNLG
N
A
L
GA
AA
GG
A
V
I
S
-
A
GL
G
YS
F
V
PVM
GAI
V-
-
A
G
L
A
-
L
LLVF
M
S
ARK
QPE
A
VCVANS
fig|670897.3.peg.2261
Escherichia coli 2362-75
MKINYP
L
LALA
I
GAFG
I
GTTEF
S
PMGLL
PV
IA
RG
V
D
VSIPAAG
M
L
IS
A
YA
V
GV
M
VGAP
LMT
L
LL
S
HRA
RR
SA
LIFL
M
A
I
F
TL
GNVLS
A
IA
P
D
Y
MT
L
M
L
SRI
LTS
L
N
HGAFFGLG
S
V
VA
AS
V
V
P
K
H
K
Q
A
S
AVA
T
M
FM
G
L
TLAN
I
G
GVP
AA
T
W
LG
E
T
I
GWRM
S
FLA
T
A
GLG
VI
S
M
V
SL
FFS
LP
KGGA
G
A
R
P
E
V
-
K
KELVV
L
M
RP
Q
VL
S
A
L
L
T
TV
L
G
AG
A
M
FT
L
Y
T
YI
S
P
V
LQ
S
IT
H
V
T
PV
F
V
TA
M
L
V
LIG
V
G
FS
IGN
Y
L
G
GKL
AD
R
S
VN---G
T
LKG
FLL
L
L
MV
I
ML
A
IP
F
L
A
RN
E
FGAA
I
S
---
MVV
WGAA
T
FAV
VP
PLQM
R
V
M
RV
A
SE
A
PG
L
SS
S
VNI
GAFNLG
N
A
L
GA
AA
GG
A
V
I
S
-
A
GL
G
YS
F
V
PVM
GAI
V-
-
A
G
L
A
-
L
LLVF
M
S
VRK
QPETVCVANS
fig|340185.3.peg.3346
Escherichia coli E22
MKINYP
L
LALA
I
GAFG
I
GTTEF
S
PMGLL
PV
IA
RG
V
D
VSIPAAG
M
L
IS
A
YA
V
GV
M
VGAP
LMT
L
LL
S
HRA
RR
SA
LIFL
M
A
I
F
TL
GNVLS
A
IA
P
D
Y
MT
L
M
L
SRI
LTS
L
N
HGAFFGLG
S
V
VA
AS
V
V
P
K
H
K
Q
A
S
AVA
T
M
FM
G
L
TLAN
I
G
GVP
AA
T
W
LG
E
T
I
GWRM
S
FLA
T
A
GLG
VI
S
M
V
SL
FFS
LP
KGGA
G
A
R
P
E
V
-
K
KELAV
L
M
RP
Q
VL
S
A
L
L
T
TV
L
G
AG
A
M
FT
L
Y
T
YI
S
P
V
LQ
S
IT
H
A
T
PV
F
V
TA
M
L
V
LIG
V
G
FS
IGN
Y
L
G
GKL
AD
R
S
VN---G
T
LKG
FLL
L
L
MV
I
ML
A
IP
F
L
A
RN
E
FGAA
I
S
---
MVV
WGAA
T
FAV
VP
PLQM
R
V
M
CV
A
SE
A
PG
L
SS
S
VNI
GAFNLG
N
A
L
GA
AA
GG
A
V
I
S
-
A
GL
G
YS
F
V
PVM
GAI
V-
-
A
G
L
A
-
L
LLVF
M
S
ARK
QPETVCVANS
fig|340185.4.peg.3522
Escherichia coli E22
MKINYP
L
LALA
I
GAFG
I
GTTEF
S
PMGLL
PV
IA
RG
V
D
VSIPAAG
M
L
IS
A
YA
V
GV
M
VGAP
LMT
L
LL
S
HRA
RR
SA
LIFL
M
A
I
F
TL
GNVLS
A
IA
P
D
Y
MT
L
M
L
SRI
LTS
L
N
HGAFFGLG
S
V
VA
AS
V
V
P
K
H
K
Q
A
S
AVA
T
M
FM
G
L
TLAN
I
G
GVP
AA
T
W
LG
E
T
I
GWRM
S
FLA
T
A
GLG
VI
S
M
V
SL
FFS
LP
KGGA
G
A
R
P
E
V
-
K
KELAV
L
M
RP
Q
VL
S
A
L
L
T
TV
L
G
AG
A
M
FT
L
Y
T
YI
S
P
V
LQ
S
IT
H
A
T
PV
F
V
TA
M
L
V
LIG
V
G
FS
IGN
Y
L
G
GKL
AD
R
S
VN---G
T
LKG
FLL
L
L
MV
I
ML
A
IP
F
L
A
RN
E
FGAA
I
S
---
MVV
WGAA
T
FAV
VP
PLQM
R
V
M
CV
A
SE
A
PG
L
SS
S
VNI
GAFNLG
N
A
L
GA
AA
GG
A
V
I
S
-
A
GL
G
YS
F
V
PVM
GAI
V-
-
A
G
L
A
-
L
LLVF
M
S
ARK
QPETVCVANS
fig|316401.4.peg.1943
Escherichia coli ETEC H10407
MKINYP
L
LALA
I
GAFG
I
GTTEF
S
PMGLL
PV
IA
RG
V
D
VSIPAAG
M
L
IS
A
YA
V
GV
M
VGAP
LMT
L
LL
S
HRA
RR
SA
LIFL
M
A
I
F
TL
GNVLS
A
IA
P
D
Y
MT
L
M
L
SRI
LTS
L
N
HGAFFGLG
S
V
VA
AS
V
V
P
K
H
K
Q
A
S
AVA
T
M
FM
G
L
TLAN
I
G
GVP
AA
T
W
LG
E
T
I
GWRM
S
FLA
T
A
GLG
VI
S
M
V
SL
FFS
LP
KGGA
G
A
R
P
E
V
-
K
KELAV
L
M
RP
Q
VL
S
A
L
L
T
TV
L
G
AG
A
M
FT
L
Y
T
YI
S
P
V
LQ
S
IT
H
A
T
PV
F
V
TA
M
L
V
LIG
V
G
FS
IGN
Y
L
G
GKL
AD
R
S
VN---G
T
LKG
FLL
L
L
MV
I
ML
A
IP
F
L
A
RN
E
FGAA
I
S
---
MVV
WGAA
T
FAV
VS
PLQM
R
V
M
RV
P
SE
A
PG
L
SS
S
VNI
GAFNLG
N
A
L
GA
AA
GG
A
V
I
S
-
A
GL
G
YS
F
V
PVM
GAI
V-
-
A
G
L
A
-
L
LLVF
M
S
ARK
QPETVCVANS
fig|562.371.peg.4509
Escherichia coli 1044A
MKINYP
L
LALA
I
GAFG
I
GTTEF
S
PMGLL
PV
IA
RG
V
D
VSIPAAG
M
L
IS
A
YA
V
GV
M
VGAP
LMT
L
LL
S
HRA
RR
SA
LIFL
M
A
I
F
TL
GNVLS
A
IA
P
D
Y
MT
L
M
L
SRI
LTS
L
N
HGAFFGLG
S
V
VA
AS
V
V
P
K
H
K
Q
A
S
AVA
T
M
FM
G
L
TLAN
I
G
GVP
AA
T
W
LG
E
T
I
GWRM
S
FLA
T
A
GLG
VI
S
M
V
SL
FFS
LP
KGGA
G
A
R
P
E
V
-
K
KELAV
L
M
RP
Q
VL
S
A
L
L
T
TV
L
G
AG
A
M
FT
L
Y
T
YI
S
P
V
LQ
S
IT
H
A
T
PV
F
V
TA
M
L
V
LIG
V
G
FS
IGN
Y
L
G
GKL
AD
R
S
VN---G
T
LKG
FLL
L
L
MV
I
ML
A
IP
F
L
A
RN
K
FGAA
I
S
---
MAV
WGAA
T
FAV
VP
PLQM
R
V
M
RV
A
SE
A
PG
L
SS
S
VNI
GAFNLG
N
A
L
GA
AA
GG
A
V
I
S
-
A
GL
G
YS
F
V
PVM
GAI
V-
-
A
G
L
A
-
L
LLVF
M
S
ARK
QPETVCVANS
fig|562.373.peg.5411
Escherichia coli 1125A
MKINYP
L
LALA
I
GAFG
I
GTTEF
S
PMGLL
PV
IA
RG
V
D
VSIPAAG
M
L
IS
A
YA
V
GV
M
VGAP
LMT
L
LL
S
HRA
RR
SA
LIFL
M
A
I
F
TL
GNVLS
A
IA
P
D
Y
MT
L
M
L
SRI
LTS
L
N
HGAFFGLG
S
V
VA
AS
V
V
P
K
H
K
Q
A
S
AVA
T
M
FM
G
L
TLAN
I
G
GVP
AA
T
W
LG
E
T
I
GWRM
S
FLA
T
A
GLG
VI
S
M
V
SL
FFS
LP
KGGA
G
A
R
P
E
V
-
K
KELAV
L
M
RP
Q
VL
S
A
L
L
T
TV
L
G
AG
A
M
FT
L
Y
T
YI
S
P
V
LQ
S
IT
H
A
T
PV
F
V
TA
M
L
V
LIG
V
G
FS
IGN
Y
L
G
GKL
AD
R
S
VN---G
T
LKG
FLL
L
L
MV
I
ML
A
IP
F
L
A
RN
K
FGAA
I
S
---
MAV
WGAA
T
FAV
VP
PLQM
R
V
M
RV
A
SE
A
PG
L
SS
S
VNI
GAFNLG
N
A
L
GA
AA
GG
A
V
I
S
-
A
GL
G
YS
F
V
PVM
GAI
V-
-
A
G
L
A
-
L
LLVF
M
S
ARK
QPETVCVANS
fig|562.372.peg.4742
Escherichia coli 1212A
MKINYP
L
LALA
I
GAFG
I
GTTEF
S
PMGLL
PV
IA
RG
V
D
VSIPAAG
M
L
IS
A
YA
V
GV
M
VGAP
LMT
L
LL
S
HRA
RR
SA
LIFL
M
A
I
F
TL
GNVLS
A
IA
P
D
Y
MT
L
M
L
SRI
LTS
L
N
HGAFFGLG
S
V
VA
AS
V
V
P
K
H
K
Q
A
S
AVA
T
M
FM
G
L
TLAN
I
G
GVP
AA
T
W
LG
E
T
I
GWRM
S
FLA
T
A
GLG
VI
S
M
V
SL
FFS
LP
KGGA
G
A
R
P
E
V
-
K
KELAV
L
M
RP
Q
VL
S
A
L
L
T
TV
L
G
AG
A
M
FT
L
Y
T
YI
S
P
V
LQ
S
IT
H
A
T
PV
F
V
TA
M
L
V
LIG
V
G
FS
IGN
Y
L
G
GKL
AD
R
S
VN---G
T
LKG
FLL
L
L
MV
I
ML
A
IP
F
L
A
RN
K
FGAA
I
S
---
MAV
WGAA
T
FAV
VP
PLQM
R
V
M
RV
A
SE
A
PG
L
SS
S
VNI
GAFNLG
N
A
L
GA
AA
GG
A
V
I
S
-
A
GL
G
YS
F
V
PVM
GAI
V-
-
A
G
L
A
-
L
LLVF
M
S
ARK
QPETVCVANS
fig|562.374.peg.4370
Escherichia coli 536A
MKINYP
L
LALA
I
GAFG
I
GTTEF
S
PMGLL
PV
IA
RG
V
D
VSIPAAG
M
L
IS
A
YA
V
GV
M
VGAP
LMT
L
LL
S
HRA
RR
SA
LIFL
M
A
I
F
TL
GNVLS
A
IA
P
D
Y
MT
L
M
L
SRI
LTS
L
N
HGAFFGLG
S
V
VA
AS
V
V
P
K
H
K
Q
A
S
AVA
T
M
FM
G
L
TLAN
I
G
GVP
AA
T
W
LG
E
T
I
GWRM
S
FLA
T
A
GLG
VI
S
M
V
SL
FFS
LP
KGGA
G
A
R
P
E
V
-
K
KELAV
L
M
RP
Q
VL
S
A
L
L
T
TV
L
G
AG
A
M
FT
L
Y
T
YI
S
P
V
LQ
S
IT
H
A
T
PV
F
V
TA
M
L
V
LIG
V
G
FS
IGN
Y
L
G
GKL
AD
R
S
VN---G
T
LKG
FLL
L
L
MV
I
ML
A
IP
F
L
A
RN
K
FGAA
I
S
---
MAV
WGAA
T
FAV
VP
PLQM
R
V
M
RV
A
SE
A
PG
L
SS
S
VNI
GAFNLG
N
A
L
GA
AA
GG
A
V
I
S
-
A
GL
G
YS
F
V
PVM
GAI
V-
-
A
G
L
A
-
L
LLVF
M
S
ARK
QPETVCVANS
fig|83334.1.peg.2392
Escherichia coli O157:H7
MKINYP
L
LALA
I
GAFG
I
GTTEF
S
PMGLL
PV
IA
RG
V
D
VSIPAAG
M
L
IS
A
YA
V
GV
M
VGAP
LMT
L
LL
S
HRA
RR
SA
LIFL
M
A
I
F
TL
GNVLS
A
IA
P
D
Y
MT
L
M
L
SRI
LTS
L
N
HGAFFGLG
S
V
VA
AS
V
V
P
K
H
K
Q
A
S
AVA
T
M
FM
G
L
TLAN
I
G
GVP
AA
T
W
LG
E
T
I
GWRM
S
FLA
T
A
GLG
VI
S
M
V
SL
FFS
LP
KGGA
G
A
R
P
E
V
-
K
KELAV
L
M
RP
Q
VL
S
A
L
L
T
TV
L
G
AG
A
M
FT
L
Y
T
YI
S
P
V
LQ
S
IT
H
A
T
PV
F
V
TA
M
L
V
LIG
V
G
FS
IGN
Y
L
G
GKL
AD
R
S
VN---G
T
LKG
FLL
L
L
MV
I
ML
A
IP
F
L
A
RN
K
FGAA
I
S
---
MAV
WGAA
T
FAV
VP
PLQM
R
V
M
RV
A
SE
A
PG
L
SS
S
VNI
GAFNLG
N
A
L
GA
AA
GG
A
V
I
S
-
A
GL
G
YS
F
V
PVM
GAI
V-
-
A
G
L
A
-
L
LLVF
M
S
ARK
QPETVCVANS
fig|155864.1.peg.2401
Escherichia coli O157:H7 EDL933
MKINYP
L
LALA
I
GAFG
I
GTTEF
S
PMGLL
PV
IA
RG
V
D
VSIPAAG
M
L
IS
A
YA
V
GV
M
VGAP
LMT
L
LL
S
HRA
RR
SA
LIFL
M
A
I
F
TL
GNVLS
A
IA
P
D
Y
MT
L
M
L
SRI
LTS
L
N
HGAFFGLG
S
V
VA
AS
V
V
P
K
H
K
Q
A
S
AVA
T
M
FM
G
L
TLAN
I
G
GVP
AA
T
W
LG
E
T
I
GWRM
S
FLA
T
A
GLG
VI
S
M
V
SL
FFS
LP
KGGA
G
A
R
P
E
V
-
K
KELAV
L
M
RP
Q
VL
S
A
L
L
T
TV
L
G
AG
A
M
FT
L
Y
T
YI
S
P
V
LQ
S
IT
H
A
T
PV
F
V
TA
M
L
V
LIG
V
G
FS
IGN
Y
L
G
GKL
AD
R
S
VN---G
T
LKG
FLL
L
L
MV
I
ML
A
IP
F
L
A
RN
K
FGAA
I
S
---
MAV
WGAA
T
FAV
VP
PLQM
R
V
M
RV
A
SE
A
PG
L
SS
S
VNI
GAFNLG
N
A
L
GA
AA
GG
A
V
I
S
-
A
GL
G
YS
F
V
PVM
GAI
V-
-
A
G
L
A
-
L
LLVF
M
S
ARK
QPETVCVANS
fig|155864.8.peg.2246
Escherichia coli O157:H7 EDL933
MKINYP
L
LALA
I
GAFG
I
GTTEF
S
PMGLL
PV
IA
RG
V
D
VSIPAAG
M
L
IS
A
YA
V
GV
M
VGAP
LMT
L
LL
S
HRA
RR
SA
LIFL
M
A
I
F
TL
GNVLS
A
IA
P
D
Y
MT
L
M
L
SRI
LTS
L
N
HGAFFGLG
S
V
VA
AS
V
V
P
K
H
K
Q
A
S
AVA
T
M
FM
G
L
TLAN
I
G
GVP
AA
T
W
LG
E
T
I
GWRM
S
FLA
T
A
GLG
VI
S
M
V
SL
FFS
LP
KGGA
G
A
R
P
E
V
-
K
KELAV
L
M
RP
Q
VL
S
A
L
L
T
TV
L
G
AG
A
M
FT
L
Y
T
YI
S
P
V
LQ
S
IT
H
A
T
PV
F
V
TA
M
L
V
LIG
V
G
FS
IGN
Y
L
G
GKL
AD
R
S
VN---G
T
LKG
FLL
L
L
MV
I
ML
A
IP
F
L
A
RN
K
FGAA
I
S
---
MAV
WGAA
T
FAV
VP
PLQM
R
V
M
RV
A
SE
A
PG
L
SS
S
VNI
GAFNLG
N
A
L
GA
AA
GG
A
V
I
S
-
A
GL
G
YS
F
V
PVM
GAI
V-
-
A
G
L
A
-
L
LLVF
M
S
ARK
QPETVCVANS
fig|444454.5.peg.1108
Escherichia coli O157:H7 str. EC4024
MKINYP
L
LALA
I
GAFG
I
GTTEF
S
PMGLL
PV
IA
RG
V
D
VSIPAAG
M
L
IS
A
YA
V
GV
M
VGAP
LMT
L
LL
S
HRA
RR
SA
LIFL
M
A
I
F
TL
GNVLS
A
IA
P
D
Y
MT
L
M
L
SRI
LTS
L
N
HGAFFGLG
S
V
VA
AS
V
V
P
K
H
K
Q
A
S
AVA
T
M
FM
G
L
TLAN
I
G
GVP
AA
T
W
LG
E
T
I
GWRM
S
FLA
T
A
GLG
VI
S
M
V
SL
FFS
LP
KGGA
G
A
R
P
E
V
-
K
KELAV
L
M
RP
Q
VL
S
A
L
L
T
TV
L
G
AG
A
M
FT
L
Y
T
YI
S
P
V
LQ
S
IT
H
A
T
PV
F
V
TA
M
L
V
LIG
V
G
FS
IGN
Y
L
G
GKL
AD
R
S
VN---G
T
LKG
FLL
L
L
MV
I
ML
A
IP
F
L
A
RN
K
FGAA
I
S
---
MAV
WGAA
T
FAV
VP
PLQM
R
V
M
RV
A
SE
A
PG
L
SS
S
VNI
GAFNLG
N
A
L
GA
AA
GG
A
V
I
S
-
A
GL
G
YS
F
V
PVM
GAI
V-
-
A
G
L
A
-
L
LLVF
M
S
ARK
QPETVCVANS
fig|444449.5.peg.592
Escherichia coli O157:H7 str. EC4042
MKINYP
L
LALA
I
GAFG
I
GTTEF
S
PMGLL
PV
IA
RG
V
D
VSIPAAG
M
L
IS
A
YA
V
GV
M
VGAP
LMT
L
LL
S
HRA
RR
SA
LIFL
M
A
I
F
TL
GNVLS
A
IA
P
D
Y
MT
L
M
L
SRI
LTS
L
N
HGAFFGLG
S
V
VA
AS
V
V
P
K
H
K
Q
A
S
AVA
T
M
FM
G
L
TLAN
I
G
GVP
AA
T
W
LG
E
T
I
GWRM
S
FLA
T
A
GLG
VI
S
M
V
SL
FFS
LP
KGGA
G
A
R
P
E
V
-
K
KELAV
L
M
RP
Q
VL
S
A
L
L
T
TV
L
G
AG
A
M
FT
L
Y
T
YI
S
P
V
LQ
S
IT
H
A
T
PV
F
V
TA
M
L
V
LIG
V
G
FS
IGN
Y
L
G
GKL
AD
R
S
VN---G
T
LKG
FLL
L
L
MV
I
ML
A
IP
F
L
A
RN
K
FGAA
I
S
---
MAV
WGAA
T
FAV
VP
PLQM
R
V
M
RV
A
SE
A
PG
L
SS
S
VNI
GAFNLG
N
A
L
GA
AA
GG
A
V
I
S
-
A
GL
G
YS
F
V
PVM
GAI
V-
-
A
G
L
A
-
L
LLVF
M
S
ARK
QPETVCVANS
fig|444448.5.peg.4901
Escherichia coli O157:H7 str. EC4045
MKINYP
L
LALA
I
GAFG
I
GTTEF
S
PMGLL
PV
IA
RG
V
D
VSIPAAG
M
L
IS
A
YA
V
GV
M
VGAP
LMT
L
LL
S
HRA
RR
SA
LIFL
M
A
I
F
TL
GNVLS
A
IA
P
D
Y
MT
L
M
L
SRI
LTS
L
N
HGAFFGLG
S
V
VA
AS
V
V
P
K
H
K
Q
A
S
AVA
T
M
FM
G
L
TLAN
I
G
GVP
AA
T
W
LG
E
T
I
GWRM
S
FLA
T
A
GLG
VI
S
M
V
SL
FFS
LP
KGGA
G
A
R
P
E
V
-
K
KELAV
L
M
RP
Q
VL
S
A
L
L
T
TV
L
G
AG
A
M
FT
L
Y
T
YI
S
P
V
LQ
S
IT
H
A
T
PV
F
V
TA
M
L
V
LIG
V
G
FS
IGN
Y
L
G
GKL
AD
R
S
VN---G
T
LKG
FLL
L
L
MV
I
ML
A
IP
F
L
A
RN
K
FGAA
I
S
---
MAV
WGAA
T
FAV
VP
PLQM
R
V
M
RV
A
SE
A
PG
L
SS
S
VNI
GAFNLG
N
A
L
GA
AA
GG
A
V
I
S
-
A
GL
G
YS
F
V
PVM
GAI
V-
-
A
G
L
A
-
L
LLVF
M
S
ARK
QPETVCVANS
fig|444453.5.peg.5180
Escherichia coli O157:H7 str. EC4076
MKINYP
L
LALA
I
GAFG
I
GTTEF
S
PMGLL
PV
IA
RG
V
D
VSIPAAG
M
L
IS
A
YA
V
GV
M
VGAP
LMT
L
LL
S
HRA
RR
SA
LIFL
M
A
I
F
TL
GNVLS
A
IA
P
D
Y
MT
L
M
L
SRI
LTS
L
N
HGAFFGLG
S
V
VA
AS
V
V
P
K
H
K
Q
A
S
AVA
T
M
FM
G
L
TLAN
I
G
GVP
AA
T
W
LG
E
T
I
GWRM
S
FLA
T
A
GLG
VI
S
M
V
SL
FFS
LP
KGGA
G
A
R
P
E
V
-
K
KELAV
L
M
RP
Q
VL
S
A
L
L
T
TV
L
G
AG
A
M
FT
L
Y
T
YI
S
P
V
LQ
S
IT
H
A
T
PV
F
V
TA
M
L
V
LIG
V
G
FS
IGN
Y
L
G
GKL
AD
R
S
VN---G
T
LKG
FLL
L
L
MV
I
ML
A
IP
F
L
A
RN
K
FGAA
I
S
---
MAV
WGAA
T
FAV
VP
PLQM
R
V
M
RV
A
SE
A
PG
L
SS
S
VNI
GAFNLG
N
A
L
GA
AA
GG
A
V
I
S
-
A
GL
G
YS
F
V
PVM
GAI
V-
-
A
G
L
A
-
L
LLVF
M
S
ARK
QPETVCVANS
fig|444452.5.peg.5178
Escherichia coli O157:H7 str. EC4113
MKINYP
L
LALA
I
GAFG
I
GTTEF
S
PMGLL
PV
IA
RG
V
D
VSIPAAG
M
L
IS
A
YA
V
GV
M
VGAP
LMT
L
LL
S
HRA
RR
SA
LIFL
M
A
I
F
TL
GNVLS
A
IA
P
D
Y
MT
L
M
L
SRI
LTS
L
N
HGAFFGLG
S
V
VA
AS
V
V
P
K
H
K
Q
A
S
AVA
T
M
FM
G
L
TLAN
I
G
GVP
AA
T
W
LG
E
T
I
GWRM
S
FLA
T
A
GLG
VI
S
M
V
SL
FFS
LP
KGGA
G
A
R
P
E
V
-
K
KELAV
L
M
RP
Q
VL
S
A
L
L
T
TV
L
G
AG
A
M
FT
L
Y
T
YI
S
P
V
LQ
S
IT
H
A
T
PV
F
V
TA
M
L
V
LIG
V
G
FS
IGN
Y
L
G
GKL
AD
R
S
VN---G
T
LKG
FLL
L
L
MV
I
ML
A
IP
F
L
A
RN
K
FGAA
I
S
---
MAV
WGAA
T
FAV
VP
PLQM
R
V
M
RV
A
SE
A
PG
L
SS
S
VNI
GAFNLG
N
A
L
GA
AA
GG
A
V
I
S
-
A
GL
G
YS
F
V
PVM
GAI
V-
-
A
G
L
A
-
L
LLVF
M
S
ARK
QPETVCVANS
fig|444450.8.peg.2412
Escherichia coli O157:H7 str. EC4115
MKINYP
L
LALA
I
GAFG
I
GTTEF
S
PMGLL
PV
IA
RG
V
D
VSIPAAG
M
L
IS
A
YA
V
GV
M
VGAP
LMT
L
LL
S
HRA
RR
SA
LIFL
M
A
I
F
TL
GNVLS
A
IA
P
D
Y
MT
L
M
L
SRI
LTS
L
N
HGAFFGLG
S
V
VA
AS
V
V
P
K
H
K
Q
A
S
AVA
T
M
FM
G
L
TLAN
I
G
GVP
AA
T
W
LG
E
T
I
GWRM
S
FLA
T
A
GLG
VI
S
M
V
SL
FFS
LP
KGGA
G
A
R
P
E
V
-
K
KELAV
L
M
RP
Q
VL
S
A
L
L
T
TV
L
G
AG
A
M
FT
L
Y
T
YI
S
P
V
LQ
S
IT
H
A
T
PV
F
V
TA
M
L
V
LIG
V
G
FS
IGN
Y
L
G
GKL
AD
R
S
VN---G
T
LKG
FLL
L
L
MV
I
ML
A
IP
F
L
A
RN
K
FGAA
I
S
---
MAV
WGAA
T
FAV
VP
PLQM
R
V
M
RV
A
SE
A
PG
L
SS
S
VNI
GAFNLG
N
A
L
GA
AA
GG
A
V
I
S
-
A
GL
G
YS
F
V
PVM
GAI
V-
-
A
G
L
A
-
L
LLVF
M
S
ARK
QPETVCVANS
fig|444451.5.peg.3431
Escherichia coli O157:H7 str. EC4196
MKINYP
L
LALA
I
GAFG
I
GTTEF
S
PMGLL
PV
IA
RG
V
D
VSIPAAG
M
L
IS
A
YA
V
GV
M
VGAP
LMT
L
LL
S
HRA
RR
SA
LIFL
M
A
I
F
TL
GNVLS
A
IA
P
D
Y
MT
L
M
L
SRI
LTS
L
N
HGAFFGLG
S
V
VA
AS
V
V
P
K
H
K
Q
A
S
AVA
T
M
FM
G
L
TLAN
I
G
GVP
AA
T
W
LG
E
T
I
GWRM
S
FLA
T
A
GLG
VI
S
M
V
SL
FFS
LP
KGGA
G
A
R
P
E
V
-
K
KELAV
L
M
RP
Q
VL
S
A
L
L
T
TV
L
G
AG
A
M
FT
L
Y
T
YI
S
P
V
LQ
S
IT
H
A
T
PV
F
V
TA
M
L
V
LIG
V
G
FS
IGN
Y
L
G
GKL
AD
R
S
VN---G
T
LKG
FLL
L
L
MV
I
ML
A
IP
F
L
A
RN
K
FGAA
I
S
---
MAV
WGAA
T
FAV
VP
PLQM
R
V
M
RV
A
SE
A
PG
L
SS
S
VNI
GAFNLG
N
A
L
GA
AA
GG
A
V
I
S
-
A
GL
G
YS
F
V
PVM
GAI
V-
-
A
G
L
A
-
L
LLVF
M
S
ARK
QPETVCVANS
fig|444447.5.peg.5088
Escherichia coli O157:H7 str. EC4206
MKINYP
L
LALA
I
GAFG
I
GTTEF
S
PMGLL
PV
IA
RG
V
D
VSIPAAG
M
L
IS
A
YA
V
GV
M
VGAP
LMT
L
LL
S
HRA
RR
SA
LIFL
M
A
I
F
TL
GNVLS
A
IA
P
D
Y
MT
L
M
L
SRI
LTS
L
N
HGAFFGLG
S
V
VA
AS
V
V
P
K
H
K
Q
A
S
AVA
T
M
FM
G
L
TLAN
I
G
GVP
AA
T
W
LG
E
T
I
GWRM
S
FLA
T
A
GLG
VI
S
M
V
SL
FFS
LP
KGGA
G
A
R
P
E
V
-
K
KELAV
L
M
RP
Q
VL
S
A
L
L
T
TV
L
G
AG
A
M
FT
L
Y
T
YI
S
P
V
LQ
S
IT
H
A
T
PV
F
V
TA
M
L
V
LIG
V
G
FS
IGN
Y
L
G
GKL
AD
R
S
VN---G
T
LKG
FLL
L
L
MV
I
ML
A
IP
F
L
A
RN
K
FGAA
I
S
---
MAV
WGAA
T
FAV
VP
PLQM
R
V
M
RV
A
SE
A
PG
L
SS
S
VNI
GAFNLG
N
A
L
GA
AA
GG
A
V
I
S
-
A
GL
G
YS
F
V
PVM
GAI
V-
-
A
G
L
A
-
L
LLVF
M
S
ARK
QPETVCVANS
fig|478004.5.peg.5520
Escherichia coli O157:H7 str. EC4401
MKINYP
L
LALA
I
GAFG
I
GTTEF
S
PMGLL
PV
IA
RG
V
D
VSIPAAG
M
L
IS
A
YA
V
GV
M
VGAP
LMT
L
LL
S
HRA
RR
SA
LIFL
M
A
I
F
TL
GNVLS
A
IA
P
D
Y
MT
L
M
L
SRI
LTS
L
N
HGAFFGLG
S
V
VA
AS
V
V
P
K
H
K
Q
A
S
AVA
T
M
FM
G
L
TLAN
I
G
GVP
AA
T
W
LG
E
T
I
GWRM
S
FLA
T
A
GLG
VI
S
M
V
SL
FFS
LP
KGGA
G
A
R
P
E
V
-
K
KELAV
L
M
RP
Q
VL
S
A
L
L
T
TV
L
G
AG
A
M
FT
L
Y
T
YI
S
P
V
LQ
S
IT
H
A
T
PV
F
V
TA
M
L
V
LIG
V
G
FS
IGN
Y
L
G
GKL
AD
R
S
VN---G
T
LKG
FLL
L
L
MV
I
ML
A
IP
F
L
A
RN
K
FGAA
I
S
---
MAV
WGAA
T
FAV
VP
PLQM
R
V
M
RV
A
SE
A
PG
L
SS
S
VNI
GAFNLG
N
A
L
GA
AA
GG
A
V
I
S
-
A
GL
G
YS
F
V
PVM
GAI
V-
-
A
G
L
A
-
L
LLVF
M
S
ARK
QPETVCVANS
fig|478006.5.peg.5578
Escherichia coli O157:H7 str. EC4501
MKINYP
L
LALA
I
GAFG
I
GTTEF
S
PMGLL
PV
IA
RG
V
D
VSIPAAG
M
L
IS
A
YA
V
GV
M
VGAP
LMT
L
LL
S
HRA
RR
SA
LIFL
M
A
I
F
TL
GNVLS
A
IA
P
D
Y
MT
L
M
L
SRI
LTS
L
N
HGAFFGLG
S
V
VA
AS
V
V
P
K
H
K
Q
A
S
AVA
T
M
FM
G
L
TLAN
I
G
GVP
AA
T
W
LG
E
T
I
GWRM
S
FLA
T
A
GLG
VI
S
M
V
SL
FFS
LP
KGGA
G
A
R
P
E
V
-
K
KELAV
L
M
RP
Q
VL
S
A
L
L
T
TV
L
G
AG
A
M
FT
L
Y
T
YI
S
P
V
LQ
S
IT
H
A
T
PV
F
V
TA
M
L
V
LIG
V
G
FS
IGN
Y
L
G
GKL
AD
R
S
VN---G
T
LKG
FLL
L
L
MV
I
ML
A
IP
F
L
A
RN
K
FGAA
I
S
---
MAV
WGAA
T
FAV
VP
PLQM
R
V
M
RV
A
SE
A
PG
L
SS
S
VNI
GAFNLG
N
A
L
GA
AA
GG
A
V
I
S
-
A
GL
G
YS
F
V
PVM
GAI
V-
-
A
G
L
A
-
L
LLVF
M
S
ARK
QPETVCVANS
fig|478008.5.peg.5566
Escherichia coli O157:H7 str. EC869
MKINYP
L
LALA
I
GAFG
I
GTTEF
S
PMGLL
PV
IA
RG
V
D
VSIPAAG
M
L
IS
A
YA
V
GV
M
VGAP
LMT
L
LL
S
HRA
RR
SA
LIFL
M
A
I
F
TL
GNVLS
A
IA
P
D
Y
MT
L
M
L
SRI
LTS
L
N
HGAFFGLG
S
V
VA
AS
V
V
P
K
H
K
Q
A
S
AVA
T
M
FM
G
L
TLAN
I
G
GVP
AA
T
W
LG
E
T
I
GWRM
S
FLA
T
A
GLG
VI
S
M
V
SL
FFS
LP
KGGA
G
A
R
P
E
V
-
K
KELAV
L
M
RP
Q
VL
S
A
L
L
T
TV
L
G
AG
A
M
FT
L
Y
T
YI
S
P
V
LQ
S
IT
H
A
T
PV
F
V
TA
M
L
V
LIG
V
G
FS
IGN
Y
L
G
GKL
AD
R
S
VN---G
T
LKG
FLL
L
L
MV
I
ML
A
IP
F
L
A
RN
K
FGAA
I
S
---
MAV
WGAA
T
FAV
VP
PLQM
R
V
M
RV
A
SE
A
PG
L
SS
S
VNI
GAFNLG
N
A
L
GA
AA
GG
A
V
I
S
-
A
GL
G
YS
F
V
PVM
GAI
V-
-
A
G
L
A
-
L
LLVF
M
S
ARK
QPETVCVANS
fig|637388.3.peg.4982
Escherichia coli O157:H7 str. FRIK2000
MKINYP
L
LALA
I
GAFG
I
GTTEF
S
PMGLL
PV
IA
RG
V
D
VSIPAAG
M
L
IS
A
YA
V
GV
M
VGAP
LMT
L
LL
S
HRA
RR
SA
LIFL
M
A
I
F
TL
GNVLS
A
IA
P
D
Y
MT
L
M
L
SRI
LTS
L
N
HGAFFGLG
S
V
VA
AS
V
V
P
K
H
K
Q
A
S
AVA
T
M
FM
G
L
TLAN
I
G
GVP
AA
T
W
LG
E
T
I
GWRM
S
FLA
T
A
GLG
VI
S
M
V
SL
FFS
LP
KGGA
G
A
R
P
E
V
-
K
KELAV
L
M
RP
Q
VL
S
A
L
L
T
TV
L
G
AG
A
M
FT
L
Y
T
YI
S
P
V
LQ
S
IT
H
A
T
PV
F
V
TA
M
L
V
LIG
V
G
FS
IGN
Y
L
G
GKL
AD
R
S
VN---G
T
LKG
FLL
L
L
MV
I
ML
A
IP
F
L
A
RN
K
FGAA
I
S
---
MAV
WGAA
T
FAV
VP
PLQM
R
V
M
RV
A
SE
A
PG
L
SS
S
VNI
GAFNLG
N
A
L
GA
AA
GG
A
V
I
S
-
A
GL
G
YS
F
V
PVM
GAI
V-
-
A
G
L
A
-
L
LLVF
M
S
ARK
QPETVCVANS
fig|570506.3.peg.4250
Escherichia coli O157:H7 str. FRIK966
MKINYP
L
LALA
I
GAFG
I
GTTEF
S
PMGLL
PV
IA
RG
V
D
VSIPAAG
M
L
IS
A
YA
V
GV
M
VGAP
LMT
L
LL
S
HRA
RR
SA
LIFL
M
A
I
F
TL
GNVLS
A
IA
P
D
Y
MT
L
M
L
SRI
LTS
L
N
HGAFFGLG
S
V
VA
AS
V
V
P
K
H
K
Q
A
S
AVA
T
M
FM
G
L
TLAN
I
G
GVP
AA
T
W
LG
E
T
I
GWRM
S
FLA
T
A
GLG
VI
S
M
V
SL
FFS
LP
KGGA
G
A
R
P
E
V
-
K
KELAV
L
M
RP
Q
VL
S
A
L
L
T
TV
L
G
AG
A
M
FT
L
Y
T
YI
S
P
V
LQ
S
IT
H
A
T
PV
F
V
TA
M
L
V
LIG
V
G
FS
IGN
Y
L
G
GKL
AD
R
S
VN---G
T
LKG
FLL
L
L
MV
I
ML
A
IP
F
L
A
RN
K
FGAA
I
S
---
MAV
WGAA
T
FAV
VP
PLQM
R
V
M
RV
A
SE
A
PG
L
SS
S
VNI
GAFNLG
N
A
L
GA
AA
GG
A
V
I
S
-
A
GL
G
YS
F
V
PVM
GAI
V-
-
A
G
L
A
-
L
LLVF
M
S
ARK
QPETVCVANS
fig|386585.9.peg.2477
Escherichia coli O157:H7 str. Sakai
MKINYP
L
LALA
I
GAFG
I
GTTEF
S
PMGLL
PV
IA
RG
V
D
VSIPAAG
M
L
IS
A
YA
V
GV
M
VGAP
LMT
L
LL
S
HRA
RR
SA
LIFL
M
A
I
F
TL
GNVLS
A
IA
P
D
Y
MT
L
M
L
SRI
LTS
L
N
HGAFFGLG
S
V
VA
AS
V
V
P
K
H
K
Q
A
S
AVA
T
M
FM
G
L
TLAN
I
G
GVP
AA
T
W
LG
E
T
I
GWRM
S
FLA
T
A
GLG
VI
S
M
V
SL
FFS
LP
KGGA
G
A
R
P
E
V
-
K
KELAV
L
M
RP
Q
VL
S
A
L
L
T
TV
L
G
AG
A
M
FT
L
Y
T
YI
S
P
V
LQ
S
IT
H
A
T
PV
F
V
TA
M
L
V
LIG
V
G
FS
IGN
Y
L
G
GKL
AD
R
S
VN---G
T
LKG
FLL
L
L
MV
I
ML
A
IP
F
L
A
RN
K
FGAA
I
S
---
MAV
WGAA
T
FAV
VP
PLQM
R
V
M
RV
A
SE
A
PG
L
SS
S
VNI
GAFNLG
N
A
L
GA
AA
GG
A
V
I
S
-
A
GL
G
YS
F
V
PVM
GAI
V-
-
A
G
L
A
-
L
LLVF
M
S
ARK
QPETVCVANS
fig|544404.4.peg.2275
Escherichia coli O157:H7 str. TW14359
MKINYP
L
LALA
I
GAFG
I
GTTEF
S
PMGLL
PV
IA
RG
V
D
VSIPAAG
M
L
IS
A
YA
V
GV
M
VGAP
LMT
L
LL
S
HRA
RR
SA
LIFL
M
A
I
F
TL
GNVLS
A
IA
P
D
Y
MT
L
M
L
SRI
LTS
L
N
HGAFFGLG
S
V
VA
AS
V
V
P
K
H
K
Q
A
S
AVA
T
M
FM
G
L
TLAN
I
G
GVP
AA
T
W
LG
E
T
I
GWRM
S
FLA
T
A
GLG
VI
S
M
V
SL
FFS
LP
KGGA
G
A
R
P
E
V
-
K
KELAV
L
M
RP
Q
VL
S
A
L
L
T
TV
L
G
AG
A
M
FT
L
Y
T
YI
S
P
V
LQ
S
IT
H
A
T
PV
F
V
TA
M
L
V
LIG
V
G
FS
IGN
Y
L
G
GKL
AD
R
S
VN---G
T
LKG
FLL
L
L
MV
I
ML
A
IP
F
L
A
RN
K
FGAA
I
S
---
MAV
WGAA
T
FAV
VP
PLQM
R
V
M
RV
A
SE
A
PG
L
SS
S
VNI
GAFNLG
N
A
L
GA
AA
GG
A
V
I
S
-
A
GL
G
YS
F
V
PVM
GAI
V-
-
A
G
L
A
-
L
LLVF
M
S
ARK
QPETVCVANS
fig|502346.5.peg.5038
Escherichia coli O157:H7 str. TW14588
MKINYP
L
LALA
I
GAFG
I
GTTEF
S
PMGLL
PV
IA
RG
V
D
VSIPAAG
M
L
IS
A
YA
V
GV
M
VGAP
LMT
L
LL
S
HRA
RR
SA
LIFL
M
A
I
F
TL
GNVLS
A
IA
P
D
Y
MT
L
M
L
SRI
LTS
L
N
HGAFFGLG
S
V
VA
AS
V
V
P
K
H
K
Q
A
S
AVA
T
M
FM
G
L
TLAN
I
G
GVP
AA
T
W
LG
E
T
I
GWRM
S
FLA
T
A
GLG
VI
S
M
V
SL
FFS
LP
KGGA
G
A
R
P
E
V
-
K
KELAV
L
M
RP
Q
VL
S
A
L
L
T
TV
L
G
AG
A
M
FT
L
Y
T
YI
S
P
V
LQ
S
IT
H
A
T
PV
F
V
TA
M
L
V
LIG
V
G
FS
IGN
Y
L
G
GKL
AD
R
S
VN---G
T
LKG
FLL
L
L
MV
I
ML
A
IP
F
L
A
RN
K
FGAA
I
S
---
MAV
WGAA
T
FAV
VP
PLQM
R
V
M
RV
A
SE
A
PG
L
SS
S
VNI
GAFNLG
N
A
L
GA
AA
GG
A
V
I
S
-
A
GL
G
YS
F
V
PVM
GAI
V-
-
A
G
L
A
-
L
LLVF
M
S
ARK
QPETVCVANS
fig|362663.8.peg.1619
Escherichia coli 536
MKINYP
L
LALA
I
GAFG
I
GTTEF
S
PMGLL
PV
IA
RG
V
D
VSIPAAG
M
L
IS
A
YA
V
GV
M
VGAP
LMT
L
LL
S
HRA
RR
SA
LIFL
M
A
I
F
TL
GNVLS
A
IA
P
D
Y
MT
L
M
L
SRI
LTS
L
N
HGAFFGLG
S
V
VA
AS
V
V
P
K
H
K
Q
A
S
AVA
T
M
FM
G
L
TLAN
I
G
GVP
AA
T
W
LG
E
T
I
GWRM
S
FLA
T
A
GLG
VI
S
M
V
SL
FFS
LP
KGGA
G
A
R
P
E
V
-
K
KELAV
L
M
RP
Q
VL
S
A
L
L
T
TV
L
G
AG
A
M
FT
L
Y
T
YI
S
P
V
LQ
S
IT
H
V
T
PV
F
V
TA
M
L
V
LIG
V
G
FS
IGN
Y
L
G
GKL
AD
R
S
VN---G
T
LKG
FLL
L
L
MV
I
ML
A
IP
F
L
A
RN
E
FGAA
I
S
---
MVV
WGAA
T
FAV
VP
PLQM
R
V
M
RV
A
SE
A
PG
L
SS
S
VNI
GAFNLG
N
A
L
GA
AA
GG
A
V
I
S
-
A
GL
G
YS
F
V
PVM
GAI
V-
-
A
G
L
A
-
L
LLVF
M
S
ARK
QPE
A
VCVANS
fig|362663.9.peg.1623
Escherichia coli 536
MKINYP
L
LALA
I
GAFG
I
GTTEF
S
PMGLL
PV
IA
RG
V
D
VSIPAAG
M
L
IS
A
YA
V
GV
M
VGAP
LMT
L
LL
S
HRA
RR
SA
LIFL
M
A
I
F
TL
GNVLS
A
IA
P
D
Y
MT
L
M
L
SRI
LTS
L
N
HGAFFGLG
S
V
VA
AS
V
V
P
K
H
K
Q
A
S
AVA
T
M
FM
G
L
TLAN
I
G
GVP
AA
T
W
LG
E
T
I
GWRM
S
FLA
T
A
GLG
VI
S
M
V
SL
FFS
LP
KGGA
G
A
R
P
E
V
-
K
KELAV
L
M
RP
Q
VL
S
A
L
L
T
TV
L
G
AG
A
M
FT
L
Y
T
YI
S
P
V
LQ
S
IT
H
V
T
PV
F
V
TA
M
L
V
LIG
V
G
FS
IGN
Y
L
G
GKL
AD
R
S
VN---G
T
LKG
FLL
L
L
MV
I
ML
A
IP
F
L
A
RN
E
FGAA
I
S
---
MVV
WGAA
T
FAV
VP
PLQM
R
V
M
RV
A
SE
A
PG
L
SS
S
VNI
GAFNLG
N
A
L
GA
AA
GG
A
V
I
S
-
A
GL
G
YS
F
V
PVM
GAI
V-
-
A
G
L
A
-
L
LLVF
M
S
ARK
QPE
A
VCVANS
fig|340197.3.peg.3540
Escherichia coli F11
MKINYP
L
LALA
I
GAFG
I
GTTEF
S
PMGLL
PV
IA
RG
V
D
VSIPAAG
M
L
IS
A
YA
V
GV
M
VGAP
LMT
L
LL
S
HRA
RR
SA
LIFL
M
A
I
F
TL
GNVLS
A
IA
P
D
Y
MT
L
M
L
SRI
LTS
L
N
HGAFFGLG
S
V
VA
AS
V
V
P
K
H
K
Q
A
S
AVA
T
M
FM
G
L
TLAN
I
G
GVP
AA
T
W
LG
E
T
I
GWRM
S
FLA
T
A
GLG
VI
S
M
V
SL
FFS
LP
KGGA
G
A
R
P
E
V
-
K
KELAV
L
M
RP
Q
VL
S
A
L
L
T
TV
L
G
AG
A
M
FT
L
Y
T
YI
S
P
V
LQ
S
IT
H
V
T
PV
F
V
TA
M
L
V
LIG
V
G
FS
IGN
Y
L
G
GKL
AD
R
S
VN---G
T
LKG
FLL
L
L
MV
I
ML
A
IP
F
L
A
RN
E
FGAA
I
S
---
MVV
WGAA
T
FAV
VP
PLQM
R
V
M
RV
A
SE
A
PG
L
SS
S
VNI
GAFNLG
N
A
L
GA
AA
GG
A
V
I
S
-
A
GL
G
YS
F
V
PVM
GAI
V-
-
A
G
L
A
-
L
LLVF
M
S
ARK
QPE
A
VCVANS
fig|340197.5.peg.3700
Escherichia coli F11
MKINYP
L
LALA
I
GAFG
I
GTTEF
S
PMGLL
PV
IA
RG
V
D
VSIPAAG
M
L
IS
A
YA
V
GV
M
VGAP
LMT
L
LL
S
HRA
RR
SA
LIFL
M
A
I
F
TL
GNVLS
A
IA
P
D
Y
MT
L
M
L
SRI
LTS
L
N
HGAFFGLG
S
V
VA
AS
V
V
P
K
H
K
Q
A
S
AVA
T
M
FM
G
L
TLAN
I
G
GVP
AA
T
W
LG
E
T
I
GWRM
S
FLA
T
A
GLG
VI
S
M
V
SL
FFS
LP
KGGA
G
A
R
P
E
V
-
K
KELAV
L
M
RP
Q
VL
S
A
L
L
T
TV
L
G
AG
A
M
FT
L
Y
T
YI
S
P
V
LQ
S
IT
H
V
T
PV
F
V
TA
M
L
V
LIG
V
G
FS
IGN
Y
L
G
GKL
AD
R
S
VN---G
T
LKG
FLL
L
L
MV
I
ML
A
IP
F
L
A
RN
E
FGAA
I
S
---
MVV
WGAA
T
FAV
VP
PLQM
R
V
M
RV
A
SE
A
PG
L
SS
S
VNI
GAFNLG
N
A
L
GA
AA
GG
A
V
I
S
-
A
GL
G
YS
F
V
PVM
GAI
V-
-
A
G
L
A
-
L
LLVF
M
S
ARK
QPE
A
VCVANS
fig|749550.3.peg.3216
Escherichia coli MS 200-1
MKINYP
L
LALA
I
GAFG
I
GTTEF
S
PMGLL
PV
IA
RG
V
D
VSIPAAG
M
L
IS
A
YA
V
GV
M
VGAP
LMT
L
LL
S
HRA
RR
SA
LIFL
M
A
I
F
TL
GNVLS
A
IA
P
D
Y
MT
L
M
L
SRI
LTS
L
N
HGAFFGLG
S
V
VA
AS
V
V
P
K
H
K
Q
A
S
AVA
T
M
FM
G
L
TLAN
I
G
GVP
AA
T
W
LG
E
T
I
GWRM
S
FLA
T
A
GLG
VI
S
M
V
SL
FFS
LP
KGGA
G
A
R
P
E
V
-
K
KELAV
L
M
RP
Q
VL
S
A
L
L
T
TV
L
G
AG
A
M
FT
L
Y
T
YI
S
P
V
LQ
S
IT
H
V
T
PV
F
V
TA
M
L
V
LIG
V
G
FS
IGN
Y
L
G
GKL
AD
R
S
VN---G
T
LKG
FLL
L
L
MV
I
ML
A
IP
F
L
A
RN
E
FGAA
I
S
---
MVV
WGAA
T
FAV
VP
PLQM
R
V
M
RV
A
SE
A
PG
L
SS
S
VNI
GAFNLG
N
A
L
GA
AA
GG
A
V
I
S
-
A
GL
G
YS
F
V
PVM
GAI
V-
-
A
G
L
A
-
L
LLVF
M
S
ARK
QPE
A
VCVANS
fig|525281.3.peg.846
Escherichia coli 83972
MKINYP
L
LALA
I
GAFG
I
GTTEF
S
PMGLL
PV
IA
RG
V
D
VSIPAAG
M
L
IS
A
YA
V
GV
M
VGAP
LMT
L
LL
S
HRA
RR
SA
LIFL
M
A
I
F
TL
GNVLS
A
IA
P
D
Y
MT
L
M
L
SRI
LTS
L
N
HGAFFGLG
S
V
VA
AS
V
V
P
K
H
K
Q
A
S
AVA
T
M
FM
G
L
TLAN
I
G
GVP
AA
T
W
LG
E
T
I
GWRM
S
FLA
T
A
GLG
VI
S
M
V
SL
FLS
LP
KGGA
G
A
R
P
E
V
-
K
KELAV
L
M
RP
Q
VL
S
A
L
L
T
TV
L
G
AG
A
M
FT
L
Y
T
YI
S
P
V
LQ
S
IT
H
A
T
PV
F
V
TA
M
L
V
LIG
V
G
FS
IGN
Y
L
G
GKL
AD
R
S
VN---G
T
LKG
FLL
L
L
MV
I
ML
A
IP
F
L
A
RN
E
FGAA
I
S
---
MVV
WGAA
T
FAV
VP
PLQM
R
V
M
RV
A
SE
A
PG
L
SS
S
VNI
GAFNLG
N
A
L
GA
AA
GG
A
V
I
S
-
A
GL
G
YS
F
V
PVM
GAI
V-
-
A
G
L
A
-
L
LLVF
M
S
ARK
QPE
A
VCVANS
fig|655817.3.peg.2000
Escherichia coli ABU 83972
MKINYP
L
LALA
I
GAFG
I
GTTEF
S
PMGLL
PV
IA
RG
V
D
VSIPAAG
M
L
IS
A
YA
V
GV
M
VGAP
LMT
L
LL
S
HRA
RR
SA
LIFL
M
A
I
F
TL
GNVLS
A
IA
P
D
Y
MT
L
M
L
SRI
LTS
L
N
HGAFFGLG
S
V
VA
AS
V
V
P
K
H
K
Q
A
S
AVA
T
M
FM
G
L
TLAN
I
G
GVP
AA
T
W
LG
E
T
I
GWRM
S
FLA
T
A
GLG
VI
S
M
V
SL
FLS
LP
KGGA
G
A
R
P
E
V
-
K
KELAV
L
M
RP
Q
VL
S
A
L
L
T
TV
L
G
AG
A
M
FT
L
Y
T
YI
S
P
V
LQ
S
IT
H
A
T
PV
F
V
TA
M
L
V
LIG
V
G
FS
IGN
Y
L
G
GKL
AD
R
S
VN---G
T
LKG
FLL
L
L
MV
I
ML
A
IP
F
L
A
RN
E
FGAA
I
S
---
MVV
WGAA
T
FAV
VP
PLQM
R
V
M
RV
A
SE
A
PG
L
SS
S
VNI
GAFNLG
N
A
L
GA
AA
GG
A
V
I
S
-
A
GL
G
YS
F
V
PVM
GAI
V-
-
A
G
L
A
-
L
LLVF
M
S
ARK
QPE
A
VCVANS
fig|199310.1.peg.1989
Escherichia coli CFT073
MKINYP
L
LALA
I
GAFG
I
GTTEF
S
PMGLL
PV
IA
RG
V
D
VSIPAAG
M
L
IS
A
YA
V
GV
M
VGAP
LMT
L
LL
S
HRA
RR
SA
LIFL
M
A
I
F
TL
GNVLS
A
IA
P
D
Y
MT
L
M
L
SRI
LTS
L
N
HGAFFGLG
S
V
VA
AS
V
V
P
K
H
K
Q
A
S
AVA
T
M
FM
G
L
TLAN
I
G
GVP
AA
T
W
LG
E
T
I
GWRM
S
FLA
T
A
GLG
VI
S
M
V
SL
FLS
LP
KGGA
G
A
R
P
E
V
-
K
KELAV
L
M
RP
Q
VL
S
A
L
L
T
TV
L
G
AG
A
M
FT
L
Y
T
YI
S
P
V
LQ
S
IT
H
A
T
PV
F
V
TA
M
L
V
LIG
V
G
FS
IGN
Y
L
G
GKL
AD
R
S
VN---G
T
LKG
FLL
L
L
MV
I
ML
A
IP
F
L
A
RN
E
FGAA
I
S
---
MVV
WGAA
T
FAV
VP
PLQM
R
V
M
RV
A
SE
A
PG
L
SS
S
VNI
GAFNLG
N
A
L
GA
AA
GG
A
V
I
S
-
A
GL
G
YS
F
V
PVM
GAI
V-
-
A
G
L
A
-
L
LLVF
M
S
ARK
QPE
A
VCVANS
fig|199310.4.peg.1919
Escherichia coli CFT073
MKINYP
L
LALA
I
GAFG
I
GTTEF
S
PMGLL
PV
IA
RG
V
D
VSIPAAG
M
L
IS
A
YA
V
GV
M
VGAP
LMT
L
LL
S
HRA
RR
SA
LIFL
M
A
I
F
TL
GNVLS
A
IA
P
D
Y
MT
L
M
L
SRI
LTS
L
N
HGAFFGLG
S
V
VA
AS
V
V
P
K
H
K
Q
A
S
AVA
T
M
FM
G
L
TLAN
I
G
GVP
AA
T
W
LG
E
T
I
GWRM
S
FLA
T
A
GLG
VI
S
M
V
SL
FLS
LP
KGGA
G
A
R
P
E
V
-
K
KELAV
L
M
RP
Q
VL
S
A
L
L
T
TV
L
G
AG
A
M
FT
L
Y
T
YI
S
P
V
LQ
S
IT
H
A
T
PV
F
V
TA
M
L
V
LIG
V
G
FS
IGN
Y
L
G
GKL
AD
R
S
VN---G
T
LKG
FLL
L
L
MV
I
ML
A
IP
F
L
A
RN
E
FGAA
I
S
---
MVV
WGAA
T
FAV
VP
PLQM
R
V
M
RV
A
SE
A
PG
L
SS
S
VNI
GAFNLG
N
A
L
GA
AA
GG
A
V
I
S
-
A
GL
G
YS
F
V
PVM
GAI
V-
-
A
G
L
A
-
L
LLVF
M
S
ARK
QPE
A
VCVANS
fig|749546.3.peg.4561
Escherichia coli MS 185-1
MKINYP
L
LALA
I
GAFG
I
GTTEF
S
PMGLL
PV
IA
RG
V
D
VSIPAAG
M
L
IS
A
YA
V
GV
M
VGAP
LMT
L
LL
S
HRA
RR
SA
LIFL
M
A
I
F
TL
GNVLS
A
IA
P
D
Y
MT
L
M
L
SRI
LTS
L
N
HGAFFGLG
S
V
VA
AS
V
V
P
K
H
K
Q
A
S
AVA
T
M
FM
G
L
TLAN
I
G
GVP
AA
T
W
LG
E
T
I
GWRM
S
FLA
T
A
GLG
VI
S
M
V
SL
FLS
LP
KGGA
G
A
R
P
E
V
-
K
KELAV
L
M
RP
Q
VL
S
A
L
L
T
TV
L
G
AG
A
M
FT
L
Y
T
YI
S
P
V
LQ
S
IT
H
A
T
PV
F
V
TA
M
L
V
LIG
V
G
FS
IGN
Y
L
G
GKL
AD
R
S
VN---G
T
LKG
FLL
L
L
MV
I
ML
A
IP
F
L
A
RN
E
FGAA
I
S
---
MVV
WGAA
T
FAV
VP
PLQM
R
V
M
RV
A
SE
A
PG
L
SS
S
VNI
GAFNLG
N
A
L
GA
AA
GG
A
V
I
S
-
A
GL
G
YS
F
V
PVM
GAI
V-
-
A
G
L
A
-
L
LLVF
M
S
ARK
QPE
A
VCVANS
fig|749528.3.peg.4881
Escherichia coli MS 45-1
MKINYP
L
LALA
I
GAFG
I
GTTEF
S
PMGLL
PV
IA
RG
V
D
VSIPAAG
M
L
IS
A
YA
V
GV
M
VGAP
LMT
L
LL
S
HRA
RR
SA
LIFL
M
A
I
F
TL
GNVLS
A
IA
P
D
Y
MT
L
M
L
SRI
LTS
L
N
HGAFFGLG
S
V
VA
AS
V
V
P
K
H
K
Q
A
S
AVA
T
M
FM
G
L
TLAN
I
G
GVP
AA
T
W
LG
E
T
I
GWRM
S
FLA
T
A
GLG
VI
S
M
V
SL
FLS
LP
KGGA
G
A
R
P
E
V
-
K
KELAV
L
M
RP
Q
VL
S
A
L
L
T
TV
L
G
AG
A
M
FT
L
Y
T
YI
S
P
V
LQ
S
IT
H
A
T
PV
F
V
TA
M
L
V
LIG
V
G
FS
IGN
Y
L
G
GKL
AD
R
S
VN---G
T
LKG
FLL
L
L
MV
I
ML
A
IP
F
L
A
RN
E
FGAA
I
S
---
MVV
WGAA
T
FAV
VP
PLQM
R
V
M
RV
A
SE
A
PG
L
SS
S
VNI
GAFNLG
N
A
L
GA
AA
GG
A
V
I
S
-
A
GL
G
YS
F
V
PVM
GAI
V-
-
A
G
L
A
-
L
LLVF
M
S
ARK
QPE
A
VCVANS
fig|656440.3.peg.1509
Escherichia coli TA206
MKINYP
L
LALA
I
GAFG
I
GTTEF
S
PMGLL
PV
IA
RG
V
D
VSIPAAG
M
L
IS
A
YA
V
GV
M
VGAP
LMT
L
LL
S
HRA
RR
SA
LIFL
M
A
I
F
TL
GNVLS
A
IA
P
D
Y
MT
L
M
L
SRI
LTS
L
N
HGAFFGLG
S
V
VA
AS
V
V
P
K
H
K
Q
A
S
AVA
T
M
FM
G
L
TLAN
I
G
GVP
AA
T
W
LG
E
T
I
GWRM
S
FLA
T
A
GLG
VI
S
M
V
SL
FLS
LP
KGGA
G
A
R
P
E
V
-
K
KELAV
L
M
RP
Q
VL
S
A
L
L
T
TV
L
G
AG
A
M
FT
L
Y
T
YI
S
P
V
LQ
S
IT
H
A
T
PV
F
V
TA
M
L
V
LIG
V
G
FS
IGN
Y
L
G
GKL
AD
R
S
VN---G
T
LKG
FLL
L
L
MV
I
ML
A
IP
F
L
A
RN
E
FGAA
I
S
---
MVV
WGAA
T
FAV
VP
PLQM
R
V
M
RV
A
SE
A
PG
L
SS
S
VNI
GAFNLG
N
A
L
GA
AA
GG
A
V
I
S
-
A
GL
G
YS
F
V
PVM
GAI
V-
-
A
G
L
A
-
L
LLVF
M
S
ARK
QPE
A
VCVANS
fig|562.376.peg.2892
Escherichia coli WV_060327
MKINYP
L
LALA
I
GAFG
I
GTTEF
S
PMGLL
PV
IA
RG
V
D
VSIPAAG
M
L
IS
A
YA
V
GV
M
VGAP
LMT
L
LL
S
HRA
RR
SA
LIFL
M
A
I
F
TL
GNVLS
A
IA
P
D
Y
MT
L
M
L
SRI
LTS
L
N
HGAFFGLG
S
V
VA
AS
V
V
P
K
H
K
Q
A
S
AVA
T
M
FM
G
L
TLA
SI
G
GVP
AA
T
W
LG
E
T
I
GWRM
S
FLA
T
A
GLG
VI
S
M
V
SL
FFS
LP
KGGA
G
A
R
P
E
V
-
K
KELAV
L
M
RP
Q
VL
S
A
L
L
T
TV
L
G
AG
A
M
FT
L
Y
T
YI
S
P
V
LQ
S
IT
H
A
T
PV
F
V
TA
M
L
V
LIG
V
G
FS
IGN
Y
L
G
GKL
AD
R
S
VN---G
T
LKG
FLL
L
L
MV
I
ML
A
IP
F
L
A
HN
E
FGAA
I
S
---
MVV
WGAA
T
FAV
VP
PLQM
R
V
M
RV
A
SE
A
PG
L
SS
S
VNI
GAFNLG
N
A
L
GA
AA
GG
A
V
I
S
-
A
GL
G
YS
F
V
PVM
GAI
V-
-
A
G
L
A
-
L
LLVF
M
S
ARK
QPETVCVANS
fig|749531.3.peg.4901
Escherichia coli MS 69-1
MKINYP
L
LALA
I
GAFG
I
GTTEF
S
PMGLL
PV
IA
RG
V
D
VSIPAAG
M
L
IS
A
YA
V
GV
M
VGAP
LMT
L
LL
S
HRA
RR
SA
LIFL
M
A
I
F
TL
GNVLS
A
IA
P
D
Y
MT
L
M
L
SRI
LTS
L
N
HGAFFGLG
S
V
VA
AS
V
V
P
K
H
K
Q
A
S
AVA
T
M
FM
G
L
TLAN
I
G
GVP
AA
T
W
LG
E
T
I
GWRM
S
FLA
T
A
GLG
VI
S
M
V
SL
FFS
LP
KGGA
G
A
R
P
E
V
-
K
KELAV
L
M
RP
Q
VL
S
A
L
L
T
TV
L
G
AG
A
M
FT
L
Y
T
YI
S
P
V
LQ
S
IT
H
A
T
PV
F
V
TA
M
L
V
LIG
V
G
FS
IGN
Y
L
G
GKL
AD
R
S
VN---G
T
LKG
FLL
L
L
MV
I
ML
A
IP
F
L
A
RN
E
FGAA
I
S
---
MVV
WGAA
T
FAV
VP
PLQM
R
V
M
RV
A
SE
A
PG
L
SS
S
VNI
GAFNLG
N
A
L
GA
AA
GG
A
V
I
S
-
A
GL
G
YS
F
V
PVM
GAI
V-
-
A
G
L
A
-
L
LLVF
M
S
ARK
QP
GN
VCVANS
fig|431946.3.peg.1579
Escherichia coli SE15
MKINYP
L
LALA
I
GAFG
I
GTTEF
S
PMGLL
PV
IA
RG
V
D
VSIPAAG
M
L
IS
A
YA
V
GV
M
VGAP
LMT
L
LL
S
HRA
RR
SA
LIFL
M
A
I
F
TL
GNVLS
A
IA
P
D
Y
MT
L
M
L
SRI
LTS
L
N
HGAFFGLG
S
V
VA
AS
V
V
P
K
H
K
Q
A
S
AVA
T
M
FM
G
L
TLAN
I
G
GVP
AA
T
W
LG
E
T
I
GWRM
S
FLA
T
A
GLG
VI
S
M
V
SL
FLS
LP
KGGA
G
A
R
P
E
V
-
K
KELAV
L
M
RP
Q
VL
S
A
L
L
T
TV
L
G
AG
A
M
FT
L
Y
T
YI
S
P
V
LQ
S
IT
H
V
T
PV
F
V
TA
M
L
V
LIG
V
G
FS
IGN
Y
L
G
GKL
AD
R
S
VN---G
T
LKG
FLL
L
L
MV
I
ML
A
IP
F
L
A
RN
E
FGAA
I
S
---
MVV
WGAA
T
FA
I
VP
PLQM
R
V
M
RV
A
SE
A
PG
L
SS
S
VNI
GAFNLG
N
A
L
GA
AA
GG
A
V
I
S
-
A
GL
G
YS
F
V
PVM
GAI
V-
-
A
G
L
A
-
L
LLVF
M
S
ARK
QPE
A
VCVANS
fig|656417.3.peg.2157
Escherichia coli M605
MKINYP
LI
ALA
I
GAFG
I
GTTEF
S
PMGLL
PV
IA
RG
V
D
VSIPAAG
M
L
IS
A
YA
V
GV
M
VGAP
LMT
L
LL
S
HRA
RR
SA
LIFL
M
A
I
F
TL
GNVLS
A
IA
P
D
Y
MT
L
M
L
SRI
LTS
L
N
HGAFFGLG
S
V
VA
AS
V
V
P
K
H
K
Q
A
S
AVA
T
M
FM
G
L
TLAN
I
G
GVP
AA
T
W
LG
E
T
I
GWRM
S
FLA
T
A
GLG
VI
S
M
V
SL
FLS
LP
KAGA
G
A
R
P
E
V
-
K
KELAV
L
M
RP
Q
VL
S
A
L
L
T
TV
L
G
AG
A
M
FT
L
Y
T
YI
S
P
V
LQ
S
IT
H
V
T
PV
F
V
TA
M
L
V
LIG
V
G
FS
IGN
Y
L
G
GKL
AD
R
S
VN---G
T
LKG
FLL
L
L
MV
I
ML
A
IP
F
L
A
RN
E
FGAA
I
S
---
MVV
WGAA
T
FAV
VP
PLQM
R
V
M
RV
A
SE
A
PG
L
SS
S
VNI
GAFNLG
N
A
L
GA
AA
GG
A
V
I
S
-
A
GL
G
YS
F
V
PVM
GAI
V-
-
A
G
L
A
-
L
LLVF
M
S
ARK
QPE
A
VCVANS
fig|405955.13.peg.1744
Escherichia coli APEC O1
MKINYP
L
LALA
I
GAFG
I
GTTEF
S
PMGLL
PV
IA
RG
V
D
VSIPAAG
M
L
IS
A
YA
V
GV
M
VGAP
LMT
L
LL
S
HRA
RR
SA
LIFL
M
A
I
F
TL
GNVLS
A
IA
P
D
Y
MT
L
M
L
SRI
LTS
L
N
HGAFFGLG
S
V
VA
AS
V
V
P
K
H
K
Q
A
S
AVA
T
M
FM
G
L
TLAN
I
G
GVP
AA
T
W
LG
E
T
I
GWRM
S
FLA
T
A
GLG
VI
S
M
V
SL
FFS
LP
KGGA
G
A
R
P
E
V
-
K
KELAV
L
M
RP
Q
VL
S
A
L
L
T
TV
L
G
AG
A
M
FT
L
Y
T
YI
S
P
V
LQ
S
IT
H
V
T
PV
F
V
TA
M
L
V
LIG
V
G
FS
IGN
Y
L
G
GKL
AD
R
S
VN---G
T
LKG
FLL
L
L
MV
I
ML
V
IP
F
L
A
RN
E
FGAA
I
S
---
MVV
WGAA
T
FAV
VP
PLQM
R
V
M
RV
A
SE
A
PG
L
SS
S
VNI
GAFNLG
N
A
L
GA
AA
GG
A
V
I
S
-
A
GL
G
YS
F
V
PVM
GAI
V-
-
A
G
L
A
-
L
LLVF
M
S
VRK
QPETVCVANS
fig|405955.9.peg.1421
Escherichia coli APEC O1
MKINYP
L
LALA
I
GAFG
I
GTTEF
S
PMGLL
PV
IA
RG
V
D
VSIPAAG
M
L
IS
A
YA
V
GV
M
VGAP
LMT
L
LL
S
HRA
RR
SA
LIFL
M
A
I
F
TL
GNVLS
A
IA
P
D
Y
MT
L
M
L
SRI
LTS
L
N
HGAFFGLG
S
V
VA
AS
V
V
P
K
H
K
Q
A
S
AVA
T
M
FM
G
L
TLAN
I
G
GVP
AA
T
W
LG
E
T
I
GWRM
S
FLA
T
A
GLG
VI
S
M
V
SL
FFS
LP
KGGA
G
A
R
P
E
V
-
K
KELAV
L
M
RP
Q
VL
S
A
L
L
T
TV
L
G
AG
A
M
FT
L
Y
T
YI
S
P
V
LQ
S
IT
H
V
T
PV
F
V
TA
M
L
V
LIG
V
G
FS
IGN
Y
L
G
GKL
AD
R
S
VN---G
T
LKG
FLL
L
L
MV
I
ML
V
IP
F
L
A
RN
E
FGAA
I
S
---
MVV
WGAA
T
FAV
VP
PLQM
R
V
M
RV
A
SE
A
PG
L
SS
S
VNI
GAFNLG
N
A
L
GA
AA
GG
A
V
I
S
-
A
GL
G
YS
F
V
PVM
GAI
V-
-
A
G
L
A
-
L
LLVF
M
S
VRK
QPETVCVANS
fig|714962.3.peg.1811
Escherichia coli IHE3034
MKINYP
L
LALA
I
GAFG
I
GTTEF
S
PMGLL
PV
IA
RG
V
D
VSIPAAG
M
L
IS
A
YA
V
GV
M
VGAP
LMT
L
LL
S
HRA
RR
SA
LIFL
M
A
I
F
TL
GNVLS
A
IA
P
D
Y
MT
L
M
L
SRI
LTS
L
N
HGAFFGLG
S
V
VA
AS
V
V
P
K
H
K
Q
A
S
AVA
T
M
FM
G
L
TLAN
I
G
GVP
AA
T
W
LG
E
T
I
GWRM
S
FLA
T
A
GLG
VI
S
M
V
SL
FFS
LP
KGGA
G
A
R
P
E
V
-
K
KELAV
L
M
RP
Q
VL
S
A
L
L
T
TV
L
G
AG
A
M
FT
L
Y
T
YI
S
P
V
LQ
S
IT
H
V
T
PV
F
V
TA
M
L
V
LIG
V
G
FS
IGN
Y
L
G
GKL
AD
R
S
VN---G
T
LKG
FLL
L
L
MV
I
ML
V
IP
F
L
A
RN
E
FGAA
I
S
---
MVV
WGAA
T
FAV
VP
PLQM
R
V
M
RV
A
SE
A
PG
L
SS
S
VNI
GAFNLG
N
A
L
GA
AA
GG
A
V
I
S
-
A
GL
G
YS
F
V
PVM
GAI
V-
-
A
G
L
A
-
L
LLVF
M
S
VRK
QPETVCVANS
fig|685038.3.peg.1674
Escherichia coli O83:H1 str. NRG 857C
MKINYP
L
LALA
I
GAFG
I
GTTEF
S
PMGLL
PV
IA
RG
V
D
VSIPAAG
M
L
IS
A
YA
V
GV
M
VGAP
LMT
L
LL
S
HRA
RR
SA
LIFL
M
A
I
F
TL
GNVLS
A
IA
P
D
Y
MT
L
M
L
SRI
LTS
L
N
HGAFFGLG
S
V
VA
AS
V
V
P
K
H
K
Q
A
S
AVA
T
M
FM
G
L
TLAN
I
G
GVP
AA
T
W
LG
E
T
I
GWRM
S
FLA
T
A
GLG
VI
S
M
V
SL
FFS
LP
KGGA
G
A
R
P
E
V
-
K
KELAV
L
M
RP
Q
VL
S
A
L
L
T
TV
L
G
AG
A
M
FT
L
Y
T
YI
S
P
V
LQ
S
IT
H
V
T
PV
F
V
TA
M
L
V
LIG
V
G
FS
IGN
Y
L
G
GKL
AD
R
S
VN---G
T
LKG
FLL
L
L
MV
I
ML
V
IP
F
L
A
RN
E
FGAA
I
S
---
MVV
WGAA
T
FAV
VP
PLQM
R
V
M
RV
A
SE
A
PG
L
SS
S
VNI
GAFNLG
N
A
L
GA
AA
GG
A
V
I
S
-
A
GL
G
YS
F
V
PVM
GAI
V-
-
A
G
L
A
-
L
LLVF
M
S
VRK
QPETVCVANS
fig|585035.6.peg.1698
Escherichia coli S88
MKINYP
L
LALA
I
GAFG
I
GTTEF
S
PMGLL
PV
IA
RG
V
D
VSIPAAG
M
L
IS
A
YA
V
GV
M
VGAP
LMT
L
LL
S
HRA
RR
SA
LIFL
M
A
I
F
TL
GNVLS
A
IA
P
D
Y
MT
L
M
L
SRI
LTS
L
N
HGAFFGLG
S
V
VA
AS
V
V
P
K
H
K
Q
A
S
AVA
T
M
FM
G
L
TLAN
I
G
GVP
AA
T
W
LG
E
T
I
GWRM
S
FLA
T
A
GLG
VI
S
M
V
SL
FFS
LP
KGGA
G
A
R
P
E
V
-
K
KELAV
L
M
RP
Q
VL
S
A
L
L
T
TV
L
G
AG
A
M
FT
L
Y
T
YI
S
P
V
LQ
S
IT
H
V
T
PV
F
V
TA
M
L
V
LIG
V
G
FS
IGN
Y
L
G
GKL
AD
R
S
VN---G
T
LKG
FLL
L
L
MV
I
ML
V
IP
F
L
A
RN
E
FGAA
I
S
---
MVV
WGAA
T
FAV
VP
PLQM
R
V
M
RV
A
SE
A
PG
L
SS
S
VNI
GAFNLG
N
A
L
GA
AA
GG
A
V
I
S
-
A
GL
G
YS
F
V
PVM
GAI
V-
-
A
G
L
A
-
L
LLVF
M
S
VRK
QPETVCVANS
fig|869729.3.peg.1881
Escherichia coli UM146
MKINYP
L
LALA
I
GAFG
I
GTTEF
S
PMGLL
PV
IA
RG
V
D
VSIPAAG
M
L
IS
A
YA
V
GV
M
VGAP
LMT
L
LL
S
HRA
RR
SA
LIFL
M
A
I
F
TL
GNVLS
A
IA
P
D
Y
MT
L
M
L
SRI
LTS
L
N
HGAFFGLG
S
V
VA
AS
V
V
P
K
H
K
Q
A
S
AVA
T
M
FM
G
L
TLAN
I
G
GVP
AA
T
W
LG
E
T
I
GWRM
S
FLA
T
A
GLG
VI
S
M
V
SL
FFS
LP
KGGA
G
A
R
P
E
V
-
K
KELAV
L
M
RP
Q
VL
S
A
L
L
T
TV
L
G
AG
A
M
FT
L
Y
T
YI
S
P
V
LQ
S
IT
H
V
T
PV
F
V
TA
M
L
V
LIG
V
G
FS
IGN
Y
L
G
GKL
AD
R
S
VN---G
T
LKG
FLL
L
L
MV
I
ML
V
IP
F
L
A
RN
E
FGAA
I
S
---
MVV
WGAA
T
FAV
VP
PLQM
R
V
M
RV
A
SE
A
PG
L
SS
S
VNI
GAFNLG
N
A
L
GA
AA
GG
A
V
I
S
-
A
GL
G
YS
F
V
PVM
GAI
V-
-
A
G
L
A
-
L
LLVF
M
S
VRK
QPETVCVANS
fig|364106.7.peg.1890
Escherichia coli UTI89
MKINYP
L
LALA
I
GAFG
I
GTTEF
S
PMGLL
PV
IA
RG
V
D
VSIPAAG
M
L
IS
A
YA
V
GV
M
VGAP
LMT
L
LL
S
HRA
RR
SA
LIFL
M
A
I
F
TL
GNVLS
A
IA
P
D
Y
MT
L
M
L
SRI
LTS
L
N
HGAFFGLG
S
V
VA
AS
V
V
P
K
H
K
Q
A
S
AVA
T
M
FM
G
L
TLAN
I
G
GVP
AA
T
W
LG
E
T
I
GWRM
S
FLA
T
A
GLG
VI
S
M
V
SL
FFS
LP
KGGA
G
A
R
P
E
V
-
K
KELAV
L
M
RP
Q
VL
S
A
L
L
T
TV
L
G
AG
A
M
FT
L
Y
T
YI
S
P
V
LQ
S
IT
H
V
T
PV
F
V
TA
M
L
V
LIG
V
G
FS
IGN
Y
L
G
GKL
AD
R
S
VN---G
T
LKG
FLL
L
L
MV
I
ML
V
IP
F
L
A
RN
E
FGAA
I
S
---
MVV
WGAA
T
FAV
VP
PLQM
R
V
M
RV
A
SE
A
PG
L
SS
S
VNI
GAFNLG
N
A
L
GA
AA
GG
A
V
I
S
-
A
GL
G
YS
F
V
PVM
GAI
V-
-
A
G
L
A
-
L
LLVF
M
S
VRK
QPETVCVANS
fig|364106.8.peg.1893
Escherichia coli UTI89
MKINYP
L
LALA
I
GAFG
I
GTTEF
S
PMGLL
PV
IA
RG
V
D
VSIPAAG
M
L
IS
A
YA
V
GV
M
VGAP
LMT
L
LL
S
HRA
RR
SA
LIFL
M
A
I
F
TL
GNVLS
A
IA
P
D
Y
MT
L
M
L
SRI
LTS
L
N
HGAFFGLG
S
V
VA
AS
V
V
P
K
H
K
Q
A
S
AVA
T
M
FM
G
L
TLAN
I
G
GVP
AA
T
W
LG
E
T
I
GWRM
S
FLA
T
A
GLG
VI
S
M
V
SL
FFS
LP
KGGA
G
A
R
P
E
V
-
K
KELAV
L
M
RP
Q
VL
S
A
L
L
T
TV
L
G
AG
A
M
FT
L
Y
T
YI
S
P
V
LQ
S
IT
H
V
T
PV
F
V
TA
M
L
V
LIG
V
G
FS
IGN
Y
L
G
GKL
AD
R
S
VN---G
T
LKG
FLL
L
L
MV
I
ML
V
IP
F
L
A
RN
E
FGAA
I
S
---
MVV
WGAA
T
FAV
VP
PLQM
R
V
M
RV
A
SE
A
PG
L
SS
S
VNI
GAFNLG
N
A
L
GA
AA
GG
A
V
I
S
-
A
GL
G
YS
F
V
PVM
GAI
V-
-
A
G
L
A
-
L
LLVF
M
S
VRK
QPETVCVANS
fig|585397.7.peg.1878
Escherichia coli ED1a
MKINYP
L
LALA
I
GAFG
I
GTTEF
S
PMGLL
PV
IA
RG
V
D
VSIPAAG
M
L
IS
A
YA
V
GV
M
VGAP
LMT
L
LL
S
HRA
RR
SA
LIFL
M
A
I
F
TL
GNVLS
A
IA
P
D
Y
MT
L
M
L
SRI
LTS
L
N
HGAFFGLG
S
V
VA
AS
V
V
P
K
H
K
Q
A
S
AVA
T
M
FM
G
L
TLAN
I
G
GVP
AA
T
W
LG
E
T
I
GWRM
S
FLA
T
A
GLG
VI
S
M
V
SL
FFS
LP
KGGA
G
A
R
P
E
V
-
K
KELAV
L
M
RP
Q
VL
S
A
L
L
T
TV
L
G
AG
A
M
FT
L
Y
T
YI
S
P
V
LQ
S
IT
H
V
T
PV
F
V
TA
M
L
V
LIG
V
G
FS
IGN
Y
L
G
GKL
AD
R
S
VN---G
T
LKG
FLL
L
L
MV
I
ML
V
IP
F
L
A
RN
E
FGAA
M
S
---
MVV
WGAA
T
FAV
VP
PLQM
R
V
M
RV
A
SE
A
PG
L
SS
S
VNI
GAFNLG
N
A
L
GA
AA
GG
A
V
I
S
-
A
GL
G
YS
F
V
PVM
GAI
V-
-
A
G
L
A
-
L
LLVF
M
S
VRK
QPETVCVANS
fig|585397.9.peg.1873
Escherichia coli ED1a
MKINYP
L
LALA
I
GAFG
I
GTTEF
S
PMGLL
PV
IA
RG
V
D
VSIPAAG
M
L
IS
A
YA
V
GV
M
VGAP
LMT
L
LL
S
HRA
RR
SA
LIFL
M
A
I
F
TL
GNVLS
A
IA
P
D
Y
MT
L
M
L
SRI
LTS
L
N
HGAFFGLG
S
V
VA
AS
V
V
P
K
H
K
Q
A
S
AVA
T
M
FM
G
L
TLAN
I
G
GVP
AA
T
W
LG
E
T
I
GWRM
S
FLA
T
A
GLG
VI
S
M
V
SL
FFS
LP
KGGA
G
A
R
P
E
V
-
K
KELAV
L
M
RP
Q
VL
S
A
L
L
T
TV
L
G
AG
A
M
FT
L
Y
T
YI
S
P
V
LQ
S
IT
H
V
T
PV
F
V
TA
M
L
V
LIG
V
G
FS
IGN
Y
L
G
GKL
AD
R
S
VN---G
T
LKG
FLL
L
L
MV
I
ML
V
IP
F
L
A
RN
E
FGAA
M
S
---
MVV
WGAA
T
FAV
VP
PLQM
R
V
M
RV
A
SE
A
PG
L
SS
S
VNI
GAFNLG
N
A
L
GA
AA
GG
A
V
I
S
-
A
GL
G
YS
F
V
PVM
GAI
V-
-
A
G
L
A
-
L
LLVF
M
S
VRK
QPETVCVANS
fig|753642.3.peg.1499
Escherichia coli NC101
MKINYP
L
LALA
I
GAFG
I
GTTEF
S
PMGLL
PV
IA
RG
V
D
VSIPAAG
M
L
IS
A
YA
V
GV
M
VGAP
LMT
L
LL
S
HRA
RR
SA
LIFL
M
A
I
F
TL
GNVLS
A
IA
P
D
Y
MT
L
M
L
SRI
LTS
L
N
HGAFFGLG
S
V
VA
AS
V
V
P
K
H
K
Q
A
S
AVA
T
M
FM
G
L
TLAN
I
G
GVP
AA
T
R
LG
E
T
I
GWRM
S
FLA
T
A
GLG
VI
S
M
V
SL
FFS
LP
KGGA
G
A
R
P
E
V
-
K
KELAV
L
M
RP
Q
VL
S
A
L
L
T
TV
L
G
AG
A
M
FT
L
Y
T
YI
S
P
V
LQ
S
IT
H
V
T
PV
F
V
TA
M
L
V
LIG
V
G
FS
IGN
Y
L
G
GKL
AD
R
S
VN---G
T
LKG
FLL
L
L
MV
I
ML
V
IP
F
L
A
RN
E
FGAA
I
S
---
MVV
WGAA
T
FAV
VP
PLQM
R
V
M
RV
A
SE
A
PG
L
SS
S
VNI
GAFNLG
N
A
L
GA
AA
GG
A
V
I
S
-
A
GL
G
YS
F
V
PVM
GAI
V-
-
A
G
L
A
-
L
LLVF
M
S
VRK
QPETVCVANS
fig|439855.10.peg.597
Escherichia coli SMS-3-5 (33-409/422)
IL
S
LALG
T
FG
L
G
MA
EF
G
I
MG
V
L
TE
L
A
HN
V
G
I
SIPAAG
H
MIS
Y
YA
L
GV
V
VGAP
IIA
L
FS
S
RYS
LK
HI
L
L
FL
V
AL
C
VI
GN
AMF
T
LS
S
SY
LM
L
A
I
G
R
L
VSG
F
P
HGAFFG
V
GA
I
V
L
SK
I
I
K
P
GK
V
T
A
AVA
G
M
VS
G
M
T
V
AN
L
LG
I
PLGT
Y
L
S
Q
E
F
S
WR
Y
TFL
L
IA
VFN
IV
V
M
A
S
V
YFW
V
P
DIRD
EA
K
G
K
L
-
R
EQFHF
LR
S
PA
PW
L
I
F
A
A
T
M
F
G
NA
G
V
F
A
W
F
SY
V
K
P
Y
M
M
F
I
S
G
F
S
ET
A
M
T
F
I
M
M
L
V
G
L
G
MV
L
GN
V
L
S
G
R
I
SG
RY
SPLRIA
A
VTD
F
II
VL
AL
LML
F
--
F
C
G
GM
K
ITSL
I
F
---
AFI
CC
A
G
L
FA
L
SA
PLQ
I
L
L
L
QN
A
KG
G
EL
L
GA
A
GGQ
I
AFNLG
S
A
V
GA
YC
GG
M
M
L
T
-
LGL
A
Y
N
Y
V
ALP
A
A
L
LS
FAA
M
S
-
SLL
L
Y
G
R
YKR
Q
fig|656443.3.peg.638
Escherichia coli TA271 (33-409/422)
IL
S
LALG
T
FG
L
G
MA
EF
S
I
MG
V
L
TE
L
A
HN
V
G
I
SIPAAG
H
MIS
Y
YA
L
GV
V
VGAP
IIA
L
FS
S
RYS
LK
HI
L
L
FL
V
AL
C
VI
GN
AMF
T
LS
S
SY
LM
L
A
I
G
R
L
VSG
F
P
HGAFFG
V
GA
I
V
L
SK
I
I
K
P
GK
V
T
A
AVA
G
M
VS
G
M
T
V
AN
L
LG
I
PLGT
Y
L
S
Q
E
F
S
WR
Y
TFL
L
IA
VFN
I
A
V
M
A
S
V
YFW
V
P
DIRD
EA
K
G
K
L
-
R
EQFHF
LR
S
PA
PW
L
I
F
A
A
T
M
F
G
NA
G
V
F
A
W
F
SY
V
K
P
Y
M
M
F
I
S
G
F
S
ET
A
M
T
F
I
M
M
L
V
G
L
G
MV
L
GN
M
L
S
G
R
I
SG
RY
SPLRIA
A
VTD
F
II
VL
AL
LML
F
--
F
C
G
GM
K
TTSL
I
F
---
AFI
CC
A
G
L
FA
L
SA
PLQ
I
L
L
L
QN
A
KG
G
EL
L
GA
A
GGQ
I
AFNLG
S
A
V
GA
YC
GG
M
M
L
T
-
LGL
A
Y
N
Y
V
ALP
A
A
L
LS
FAA
M
S
-
SLL
L
Y
G
R
YKR
Q
fig|679205.4.peg.95
Escherichia coli MS 124-1 (33-409/422)
IL
S
LALG
T
FG
L
G
MA
EF
G
I
MG
V
L
TE
L
A
HN
V
G
I
SIPAAG
H
MIS
Y
YA
L
GV
V
VGAP
IIA
L
FS
S
RYS
LK
HI
L
L
FL
V
AL
C
VI
GN
AMF
T
LS
S
SY
MM
L
A
I
G
R
L
VSG
F
P
HGAFFG
V
GA
I
V
L
SK
I
I
K
P
GK
V
T
A
AVA
G
M
VS
G
M
T
V
AN
L
LG
I
PLGT
Y
L
S
Q
E
F
S
WR
Y
TFL
L
IA
VFN
I
A
V
M
A
S
V
YFW
V
P
DIRD
EA
K
G
K
L
-
R
EQFHF
LR
S
PA
PW
L
I
F
A
A
T
M
F
G
NA
G
V
F
A
W
F
SY
V
K
P
Y
M
M
F
I
S
G
F
S
ET
A
M
T
F
I
M
M
L
V
G
L
G
MV
L
GN
M
L
S
G
R
I
SG
RY
SPLRIA
A
VTD
F
II
VL
AL
LML
F
--
F
C
G
GM
K
TTSL
I
F
---
AFI
CC
A
G
L
FA
L
SA
PLQ
I
L
L
L
QN
A
KG
G
EL
L
GA
A
GGQ
I
AFNLG
S
A
V
GA
YC
GG
M
M
L
T
-
LGL
A
Y
N
Y
V
ALP
A
A
L
LS
FAA
M
S
-
SLL
L
Y
G
R
YKR
Q
fig|340197.3.peg.3622
Escherichia coli F11 (5-381/394)
IL
S
LALG
T
FG
L
G
MA
EF
G
I
MG
V
L
TE
L
A
HN
V
G
I
SIPAAG
H
MIS
Y
YA
L
GV
V
VGAP
IIA
L
FS
S
RYS
LK
HI
L
L
FL
V
AL
C
VI
GN
AMF
T
LS
S
SY
LM
L
A
I
G
R
L
VSG
F
P
HGAFFG
V
GA
I
V
L
SK
I
I
K
P
GK
V
T
A
AVA
G
M
VS
G
M
T
V
AN
L
LG
I
PLGT
Y
L
S
Q
E
F
S
WR
Y
TFL
L
IA
VFN
I
A
V
M
A
S
V
YFW
V
P
DIRD
EA
K
G
K
L
-
R
EQFHF
LR
S
PA
PW
L
I
F
A
A
T
M
F
G
NA
G
V
F
A
W
F
SY
V
K
P
Y
M
M
F
I
S
G
F
S
ET
A
M
T
F
I
M
M
L
V
G
L
G
MV
L
GN
M
L
S
G
R
I
SG
RY
SPLRIA
A
VTD
F
II
VL
AL
LML
F
--
F
F
G
GM
K
TTSL
I
F
---
AFI
CC
A
G
L
FA
L
SA
PLQ
I
L
L
L
QN
A
KG
G
EL
L
GA
A
GGQ
I
AFNLG
S
A
V
GA
YC
GG
M
M
L
T
-
LGL
A
Y
N
Y
V
ALP
A
A
L
LS
FAA
M
S
-
SLL
L
Y
G
R
YKR
Q
fig|656437.3.peg.472
Escherichia coli TA143 (33-409/422)
IL
S
LALG
T
FG
L
G
MA
EF
G
I
MG
V
L
TE
L
A
HN
V
G
I
SIPAAG
H
MIS
Y
YA
L
GV
V
VGAP
IIA
L
FS
S
RYS
LK
HI
L
L
FL
V
AL
C
VI
GN
AMF
T
LS
S
SY
LM
L
A
I
G
R
L
VSG
F
P
HGAFFG
V
GA
I
V
L
SK
I
I
K
P
GK
V
T
A
AVA
G
M
VS
G
M
T
V
AN
L
LG
I
PLGT
Y
L
S
Q
E
F
S
WR
Y
TFL
L
IA
VFN
I
A
V
M
A
S
V
YFW
V
P
DIRD
EA
K
G
K
L
-
R
EQFHF
LR
S
PA
PW
L
I
F
A
A
T
M
F
G
NA
G
V
F
A
W
F
SY
V
K
P
Y
M
M
F
I
S
G
F
S
ET
A
M
T
F
I
M
M
L
V
G
L
G
MV
L
GN
V
L
S
G
R
I
SG
RY
SPLRIA
A
VTD
F
II
VL
AL
LML
F
--
F
C
G
GM
K
ITSL
I
F
---
AFI
CC
A
G
L
FA
L
SA
PLQ
I
L
L
L
QN
A
KG
G
EL
L
GA
A
GGQ
I
AFNLG
S
A
V
GA
YC
GG
M
M
L
T
-
LGL
A
Y
N
Y
V
ALP
A
A
L
LS
FAA
M
S
-
SLL
L
Y
G
R
YKR
Q
fig|340184.3.peg.1794
Escherichia coli B7A (5-381/394)
IL
S
LALG
T
FG
L
G
MA
EF
G
I
MG
V
L
TE
L
A
HN
V
G
I
SIPAAG
H
MIS
Y
YA
L
GV
V
VGAP
IIA
L
FS
S
RYS
LK
HI
L
L
FL
V
AL
C
VI
GN
AMF
T
LS
S
SY
LM
L
A
I
G
R
L
VSG
F
P
HGAFFG
V
GA
I
V
L
SK
I
I
K
P
GK
V
T
A
AVA
G
M
VS
G
M
T
V
AN
L
LG
I
PLGT
Y
L
S
Q
E
F
S
WR
Y
TFL
L
IA
VFN
I
A
V
M
A
S
V
YFW
V
P
DIRD
EA
K
G
K
L
-
R
EQFHF
LR
S
PA
PW
L
I
F
A
A
T
M
F
G
NA
G
V
F
A
W
F
SY
V
K
P
Y
M
M
F
I
S
G
F
S
ET
A
M
T
F
I
M
M
L
V
G
L
G
MV
L
GN
M
L
S
G
R
V
SG
RY
SPLRIA
A
VTD
F
II
VL
AL
LML
F
--
F
C
G
GM
K
ITSL
I
F
---
AFI
CC
A
G
L
FA
L
SA
PLQ
I
L
L
L
QN
A
KG
G
EL
L
GA
A
GGQ
I
AFNLG
S
A
V
GA
YC
GG
M
M
L
T
-
LGL
A
Y
N
Y
V
ALP
A
A
L
LS
FAA
M
S
-
SLL
L
Y
G
R
YKR
Q
fig|344601.3.peg.3145
Escherichia coli B171 (5-381/394)
IL
S
LALG
T
FG
L
G
MA
EF
G
I
MG
V
L
TE
L
A
HN
V
G
I
SIPAAG
H
MIS
Y
YA
L
GV
V
VGAP
IIA
L
FS
S
RYS
LK
HI
L
L
FL
V
AL
C
VI
GN
AMF
T
LS
S
SY
LM
L
A
I
G
R
L
VSG
F
P
HGAFFG
V
GA
I
V
L
SK
I
I
K
P
GK
V
T
A
AVA
G
M
VS
G
M
T
V
AN
L
LG
I
PLGT
Y
L
S
Q
E
F
S
WR
Y
TFL
L
IA
VFN
I
A
V
M
A
S
V
YFW
V
P
DIRD
EA
K
G
K
L
-
R
EQFHF
LR
S
PA
PW
L
I
F
A
A
T
M
F
G
NA
G
V
F
A
W
F
SY
V
K
P
Y
M
M
F
I
S
G
F
S
ET
A
M
T
F
I
M
M
L
V
G
L
G
MV
L
GN
V
L
S
G
R
I
SG
RY
SPLRIA
A
VTD
F
II
VL
AL
LML
F
--
F
C
G
GM
K
TTSL
I
F
---
AFI
CC
A
G
L
FA
L
SA
PLQ
I
L
L
L
QN
A
KG
G
EL
L
GA
A
GGQ
I
AFNLG
S
A
V
GA
YC
GG
M
M
L
T
-
LGL
A
Y
N
Y
V
ALP
A
A
L
LS
FAA
M
S
-
SLL
L
Y
G
R
YKR
Q
fig|340185.3.peg.3573
Escherichia coli E22 (5-381/394)
IL
S
LALG
T
FG
L
G
MA
EF
G
I
MG
V
L
TE
L
A
HN
V
G
I
SIPAAG
H
MIS
Y
YA
L
GV
V
VGAP
IIA
L
FS
S
RYS
LK
HI
L
L
FL
V
AL
C
VI
GN
AMF
T
LS
S
SY
LM
L
A
I
G
R
L
VSG
F
P
HGAFFG
V
GA
I
V
L
SK
I
I
K
P
GK
V
T
A
AVA
G
M
VS
G
M
T
V
AN
L
LG
I
PLGT
Y
L
S
Q
E
F
S
WR
Y
TFL
L
IA
VFN
I
A
V
M
A
S
V
YFW
V
P
DIRD
EA
K
G
K
L
-
R
EQFHF
LR
S
PA
PW
L
I
F
A
A
T
M
F
G
NA
G
V
F
A
W
F
SY
V
K
P
Y
M
M
F
I
S
G
F
S
ET
A
M
T
F
I
M
M
L
V
G
L
G
MV
L
GN
V
L
S
G
R
I
SG
RY
SPLRIA
A
VTD
F
II
VL
AL
LML
F
--
F
C
G
GM
K
TTSL
I
F
---
AFI
CC
A
G
L
FA
L
SA
PLQ
I
L
L
L
QN
A
KG
G
EL
L
GA
A
GGQ
I
AFNLG
S
A
V
GA
YC
GG
M
M
L
T
-
LGL
A
Y
N
Y
V
ALP
A
A
L
LS
FAA
M
S
-
SLL
L
Y
G
R
YKR
Q
fig|670897.3.peg.325
Escherichia coli 2362-75 (33-409/422)
IL
S
LALG
T
FG
L
G
MA
EF
G
I
MG
V
L
TE
L
A
HN
V
G
I
SIPAAG
H
MIS
Y
YA
L
GV
V
VGAP
IIA
L
FS
S
RYS
LK
HI
L
L
FL
V
AL
C
VI
GN
AMF
T
LS
S
SY
LM
L
A
I
G
R
L
VSG
F
P
HGAFFG
V
GA
I
V
L
SK
I
I
K
P
GK
V
T
A
AVA
G
M
VS
G
M
T
V
AN
L
LG
I
PLGT
Y
L
S
Q
E
F
S
WR
Y
TFL
L
IA
VFN
I
A
V
M
A
S
V
YFW
V
P
DIRD
EA
K
G
K
L
-
R
EQFHF
LR
S
PA
PW
L
I
F
A
A
T
M
F
G
NA
G
V
F
A
W
F
SY
V
K
P
Y
M
M
F
I
S
G
F
S
ET
A
M
T
F
I
M
M
L
V
G
L
G
MV
L
GN
M
L
S
G
R
I
SR
RY
SPLRIA
A
VTD
F
II
VL
AL
LML
F
--
F
F
G
GM
K
TTSL
I
F
---
AFI
CC
A
G
L
FA
L
SA
PLQ
I
L
L
L
QN
A
KG
G
EL
L
GA
A
GGQ
I
AFNLG
S
A
V
GA
YC
GG
M
M
L
T
-
LGL
A
Y
N
Y
V
ALP
A
A
L
LS
FAA
M
S
-
SLL
L
Y
G
R
YKR
Q
fig|216593.1.peg.3210
Escherichia coli E2348/69 (33-409/422)
IL
S
LALG
T
FG
L
G
MA
EF
G
I
MG
V
L
TE
L
A
HN
V
G
I
SIPAAG
H
MIS
Y
YA
L
GV
V
VGAP
IIA
L
FS
S
RYS
LK
HI
L
L
FL
V
AL
C
VI
GN
AMF
T
LS
S
SY
LM
L
A
I
G
R
L
VSG
F
P
HGAFFG
V
GA
I
V
L
SK
I
I
K
P
GK
V
T
A
AVA
G
M
VS
G
M
T
V
AN
L
LG
I
PLGT
Y
L
S
Q
E
F
S
WR
Y
TFL
L
IA
VFN
I
A
V
M
A
S
V
YFW
V
P
DIRD
EA
K
G
K
L
-
R
EQFHF
LR
S
PA
PW
L
I
F
A
A
T
M
F
G
NA
G
V
F
A
W
F
SY
V
K
P
Y
M
M
F
I
S
G
F
S
ET
A
M
T
F
I
M
M
L
V
G
L
G
MV
L
GN
M
L
S
G
R
I
SR
RY
SPLRIA
A
VTD
F
II
VL
AL
LML
F
--
F
F
G
GM
K
TTSL
I
F
---
AFI
CC
A
G
L
FA
L
SA
PLQ
I
L
L
L
QN
A
KG
G
EL
L
GA
A
GGQ
I
AFNLG
S
A
V
GA
YC
GG
M
M
L
T
-
LGL
A
Y
N
Y
V
ALP
A
A
L
LS
FAA
M
S
-
SLL
L
Y
G
R
YKR
Q
fig|574521.7.peg.353
Escherichia coli O127:H6 str. E2348/69 (33-409/422)
IL
S
LALG
T
FG
L
G
MA
EF
G
I
MG
V
L
TE
L
A
HN
V
G
I
SIPAAG
H
MIS
Y
YA
L
GV
V
VGAP
IIA
L
FS
S
RYS
LK
HI
L
L
FL
V
AL
C
VI
GN
AMF
T
LS
S
SY
LM
L
A
I
G
R
L
VSG
F
P
HGAFFG
V
GA
I
V
L
SK
I
I
K
P
GK
V
T
A
AVA
G
M
VS
G
M
T
V
AN
L
LG
I
PLGT
Y
L
S
Q
E
F
S
WR
Y
TFL
L
IA
VFN
I
A
V
M
A
S
V
YFW
V
P
DIRD
EA
K
G
K
L
-
R
EQFHF
LR
S
PA
PW
L
I
F
A
A
T
M
F
G
NA
G
V
F
A
W
F
SY
V
K
P
Y
M
M
F
I
S
G
F
S
ET
A
M
T
F
I
M
M
L
V
G
L
G
MV
L
GN
M
L
S
G
R
I
SR
RY
SPLRIA
A
VTD
F
II
VL
AL
LML
F
--
F
F
G
GM
K
TTSL
I
F
---
AFI
CC
A
G
L
FA
L
SA
PLQ
I
L
L
L
QN
A
KG
G
EL
L
GA
A
GGQ
I
AFNLG
S
A
V
GA
YC
GG
M
M
L
T
-
LGL
A
Y
N
Y
V
ALP
A
A
L
LS
FAA
M
S
-
SLL
L
Y
G
R
YKR
Q
fig|340186.3.peg.1804
Escherichia coli E110019 (5-381/394)
IL
S
LALG
T
FG
L
G
MA
EF
G
I
MG
V
L
TE
L
A
HN
V
G
I
SIPAAG
H
MIS
Y
YA
L
GV
V
VGAP
IIA
L
FS
S
RYS
LK
HI
L
L
FL
V
AL
C
VI
GN
AMF
T
LS
S
SY
LM
L
A
I
G
R
L
VSG
F
P
HGAFFG
V
GA
I
V
L
SK
I
I
K
P
GK
V
T
A
AVA
G
M
VS
G
M
T
V
AN
L
LG
I
PLGT
Y
L
S
Q
E
F
S
WR
Y
TFL
L
IA
VFN
I
A
V
M
A
S
V
YFW
V
P
DIRD
EA
K
G
K
L
-
R
EQFHF
LR
S
PA
PW
L
I
F
A
A
T
M
F
G
NA
G
V
F
A
W
F
SY
V
K
P
Y
M
M
F
I
S
G
F
S
ET
A
M
T
F
I
M
M
L
V
G
L
G
MV
L
GN
M
L
S
G
R
I
SG
RY
SPLRIA
A
VTD
F
II
VL
AL
LML
F
--
F
C
G
GM
K
TTSL
I
F
---
AFI
CC
A
G
L
FA
L
SA
PLQ
I
L
L
L
QN
A
KG
G
EL
L
GA
A
GGQ
I
AFNLG
S
A
V
GA
YC
GG
M
M
L
T
-
LGL
A
Y
N
Y
V
ALP
A
A
L
LS
FAA
M
S
-
SLL
L
Y
G
R
YKR
Q
fig|331111.3.peg.2965
Escherichia coli E24377A (5-381/394)
IL
S
LALG
T
FG
L
G
MA
EF
G
I
MG
V
L
TE
L
A
HN
V
G
I
SIPAAG
H
MIS
Y
YA
L
GV
V
VGAP
IIA
L
FS
S
RYS
LK
HI
L
L
FL
V
AL
C
VI
GN
AMF
T
LS
S
SY
LM
L
A
I
G
R
L
VSG
F
P
HGAFFG
V
GA
I
V
L
SK
I
I
K
P
GK
V
T
A
AVA
G
M
VS
G
M
T
V
AN
L
LG
I
PLGT
Y
L
S
Q
E
F
S
WR
Y
TFL
L
IA
VFN
I
A
V
M
A
S
V
YFW
V
P
DIRD
EA
K
G
K
L
-
R
EQFHF
LR
S
PA
PW
L
I
F
A
A
T
M
F
G
NA
G
V
F
A
W
F
SY
V
K
P
Y
M
M
F
I
S
G
F
S
ET
A
M
T
F
I
M
M
L
V
G
L
G
MV
L
GN
M
L
S
G
R
I
SG
RY
SPLRIA
A
VTD
F
II
VL
AL
LML
F
--
F
C
G
GM
K
TTSL
I
F
---
AFI
CC
A
G
L
FA
L
SA
PLQ
I
L
L
L
QN
A
KG
G
EL
L
GA
A
GGQ
I
AFNLG
S
A
V
GA
YC
GG
M
M
L
T
-
LGL
A
Y
N
Y
V
ALP
A
A
L
LS
FAA
M
S
-
SLL
L
Y
G
R
YKR
Q
fig|331112.3.peg.429
Escherichia coli HS (5-381/394)
IL
S
LALG
T
FG
L
G
MA
EF
G
I
MG
V
L
TE
L
A
HN
V
G
I
SIPAAG
H
MIS
Y
YA
L
GV
V
VGAP
IIA
L
FS
S
RYS
LK
HI
L
L
FL
V
AL
C
VI
GN
AMF
T
LS
S
SY
LM
L
A
I
G
R
L
VSG
F
P
HGAFFG
V
GA
I
V
L
SK
I
I
K
P
GK
V
T
A
AVA
G
M
VS
G
M
T
V
AN
L
LG
I
PLGT
Y
L
S
Q
E
F
S
WR
Y
TFL
L
IA
VFN
I
A
V
M
A
S
V
YFW
V
P
DIRD
EA
K
G
K
L
-
R
EQFHF
LR
S
PA
PW
L
I
F
A
A
T
M
F
G
NA
G
V
F
A
W
F
SY
V
K
P
Y
M
M
F
I
S
G
F
S
ET
A
M
T
F
I
M
M
L
V
G
L
G
MV
L
GN
M
L
S
G
R
I
SG
RY
SPLRIA
A
VTD
F
II
VL
AL
LML
F
--
F
C
G
GM
K
TTSL
I
F
---
AFI
CC
A
G
L
FA
L
SA
PLQ
I
L
L
L
QN
A
KG
G
EL
L
GA
A
GGQ
I
AFNLG
S
A
V
GA
YC
GG
M
M
L
T
-
LGL
A
Y
N
Y
V
ALP
A
A
L
LS
FAA
M
S
-
SLL
L
Y
G
R
YKR
Q
fig|155864.1.peg.442
Escherichia coli O157:H7 EDL933 (5-381/394)
IL
S
LALG
T
FG
L
G
MA
EF
G
I
MG
V
L
TE
L
A
HN
V
G
I
SIPAAG
H
MIS
Y
YA
L
GV
V
VGAP
IIA
L
FS
S
RYS
LK
HI
L
L
FL
V
AL
C
VI
GN
AMF
T
LS
S
SY
LM
L
A
I
G
R
L
VSG
F
P
HGAFFG
V
GA
I
V
L
SK
I
I
K
P
GK
V
T
A
AVA
G
M
VS
G
M
T
V
AN
L
LG
I
PLGT
Y
L
S
Q
E
F
S
WR
Y
TFL
L
IA
VFN
I
A
V
M
A
S
V
YFW
V
P
DIRD
EA
K
G
K
L
-
R
EQFHF
LR
S
PA
PW
L
I
F
A
A
T
M
F
G
NA
G
V
F
A
W
F
SY
V
K
P
Y
M
M
F
I
S
G
F
S
ET
A
M
T
F
I
M
M
L
V
G
L
G
MV
L
GN
M
L
S
G
R
I
SG
RY
SPLRIA
A
VTD
F
II
VL
AL
LML
F
--
F
C
G
GM
K
TTSL
I
F
---
AFI
CC
A
G
L
FA
L
SA
PLQ
I
L
L
L
QN
A
KG
G
EL
L
GA
A
GGQ
I
AFNLG
S
A
V
GA
YC
GG
M
M
L
T
-
LGL
A
Y
N
Y
V
ALP
A
A
L
LS
FAA
M
S
-
SLL
L
Y
G
R
YKR
Q
fig|431946.3.peg.367
Escherichia coli SE15 (33-409/422)
IL
S
LALG
T
FG
L
G
MA
EF
G
I
MG
V
L
TE
L
A
HN
V
G
I
SIPAAG
H
MIS
Y
YA
L
GV
V
VGAP
IIA
L
FS
S
RYS
LK
HI
L
L
FL
V
AL
C
VI
GN
AMF
T
LS
S
SY
LM
L
A
I
G
R
L
VSG
F
P
HGAFFG
V
GA
I
V
L
SK
I
I
K
P
GK
V
T
A
AVA
G
M
VS
G
M
T
V
AN
L
LG
I
PLGT
Y
L
S
Q
E
F
S
WR
Y
TFL
L
IA
IFN
I
A
V
M
A
S
V
YFW
V
P
DIRD
EA
K
G
K
L
-
R
EQFHF
LR
S
PA
PW
L
I
F
A
A
T
M
F
G
NA
G
V
F
A
W
F
SY
V
K
P
Y
M
M
F
I
S
G
F
S
ET
A
M
T
F
I
M
M
L
V
G
L
G
MV
L
GN
M
L
S
G
R
I
SG
RY
SPLRIA
A
VTD
F
II
VL
AL
LML
F
--
F
F
G
GM
K
TTSL
I
F
---
AFI
CC
A
G
L
FA
L
SA
PLQ
I
L
L
L
QN
A
KG
G
EL
L
GA
A
GGQ
I
AFNLG
S
A
V
GA
YC
GG
M
M
L
T
-
LGL
A
Y
N
Y
V
ALP
A
A
L
LS
FAA
M
S
-
SLL
L
Y
G
R
YKR
Q
fig|585057.4.peg.312
Escherichia coli IAI39 (33-409/422)
IL
S
LALG
T
FG
L
G
MA
EF
G
I
MG
V
L
TE
L
A
HN
V
G
I
SIPAAG
H
MIS
Y
YA
L
GV
V
VGAP
IIA
L
FS
S
RYS
LK
HI
L
L
FL
V
AL
C
VI
GN
AMF
T
LS
S
SY
LM
L
A
I
G
R
L
VSG
F
P
HGAFFG
V
GA
I
V
L
SK
I
I
K
P
GK
V
T
A
AVA
G
M
VS
G
M
T
V
AN
L
LG
I
PLGT
Y
L
S
Q
E
F
S
WR
Y
TFL
L
IA
VFN
I
A
V
M
A
S
V
YFW
V
P
DIRD
EA
K
G
K
L
-
R
EQFHF
LR
C
PA
PW
L
I
F
A
A
T
M
F
G
NA
G
V
F
A
W
F
SYI
K
P
Y
M
M
F
I
S
G
F
S
ET
A
M
T
F
I
M
M
L
V
G
L
G
MV
L
GN
V
L
S
G
R
I
SG
RY
SPLRIA
A
VTD
F
II
VL
AL
LML
F
--
F
C
G
GM
K
ITSL
I
F
---
AFI
CC
A
G
L
FA
L
SA
PLQ
I
L
L
L
QN
A
KG
G
EL
L
GA
A
GGQ
I
AFNLG
S
A
V
GA
YC
GG
M
M
L
T
-
LGL
A
Y
N
Y
V
ALP
A
A
L
LS
FAA
M
S
-
SLL
L
Y
G
R
YKR
Q
fig|585057.6.peg.311
Escherichia coli IAI39 (33-409/422)
IL
S
LALG
T
FG
L
G
MA
EF
G
I
MG
V
L
TE
L
A
HN
V
G
I
SIPAAG
H
MIS
Y
YA
L
GV
V
VGAP
IIA
L
FS
S
RYS
LK
HI
L
L
FL
V
AL
C
VI
GN
AMF
T
LS
S
SY
LM
L
A
I
G
R
L
VSG
F
P
HGAFFG
V
GA
I
V
L
SK
I
I
K
P
GK
V
T
A
AVA
G
M
VS
G
M
T
V
AN
L
LG
I
PLGT
Y
L
S
Q
E
F
S
WR
Y
TFL
L
IA
VFN
I
A
V
M
A
S
V
YFW
V
P
DIRD
EA
K
G
K
L
-
R
EQFHF
LR
C
PA
PW
L
I
F
A
A
T
M
F
G
NA
G
V
F
A
W
F
SYI
K
P
Y
M
M
F
I
S
G
F
S
ET
A
M
T
F
I
M
M
L
V
G
L
G
MV
L
GN
V
L
S
G
R
I
SG
RY
SPLRIA
A
VTD
F
II
VL
AL
LML
F
--
F
C
G
GM
K
ITSL
I
F
---
AFI
CC
A
G
L
FA
L
SA
PLQ
I
L
L
L
QN
A
KG
G
EL
L
GA
A
GGQ
I
AFNLG
S
A
V
GA
YC
GG
M
M
L
T
-
LGL
A
Y
N
Y
V
ALP
A
A
L
LS
FAA
M
S
-
SLL
L
Y
G
R
YKR
Q
fig|525281.3.peg.2516
Escherichia coli 83972 (33-409/422)
IL
S
LALG
T
FG
L
G
MA
EF
G
I
MG
V
L
TE
L
A
HN
V
G
I
SIPAAG
H
MIS
Y
YA
L
GV
V
VGAP
IIA
L
FS
S
RYS
LK
HI
L
L
FL
V
AL
C
VI
GN
AMF
T
LS
S
SY
LM
L
A
I
G
R
L
VSG
F
P
HGAFFG
V
GA
I
V
L
SK
I
I
K
P
GK
V
T
A
AVA
G
M
VS
G
M
T
V
AN
L
LG
I
PLGT
Y
L
S
Q
E
F
S
WR
Y
TFL
L
IA
VFN
I
A
V
M
A
S
V
YFW
V
P
DIRD
EA
K
G
K
L
-
R
EQFHF
LR
S
PA
PW
L
I
F
A
A
T
M
F
G
NA
G
V
F
A
W
F
SY
V
K
P
Y
M
M
F
I
S
G
F
S
ET
A
M
T
F
I
M
M
L
V
G
L
G
MV
L
GN
V
L
S
G
R
I
SG
RY
SPLRIA
A
VTD
F
II
VL
AL
LML
F
--
F
F
G
GM
K
TTSL
I
F
---
AFI
CC
A
G
L
FA
L
SA
PLQ
I
L
L
L
QN
A
KG
G
EL
L
GA
A
GGQ
I
AFNLG
S
A
V
GA
YC
GG
M
M
L
T
-
LGL
A
Y
N
Y
V
ALP
A
A
L
LS
FAA
M
S
-
SLL
L
Y
G
R
YKR
Q
fig|655817.3.peg.507
Escherichia coli ABU 83972 (33-409/422)
IL
S
LALG
T
FG
L
G
MA
EF
G
I
MG
V
L
TE
L
A
HN
V
G
I
SIPAAG
H
MIS
Y
YA
L
GV
V
VGAP
IIA
L
FS
S
RYS
LK
HI
L
L
FL
V
AL
C
VI
GN
AMF
T
LS
S
SY
LM
L
A
I
G
R
L
VSG
F
P
HGAFFG
V
GA
I
V
L
SK
I
I
K
P
GK
V
T
A
AVA
G
M
VS
G
M
T
V
AN
L
LG
I
PLGT
Y
L
S
Q
E
F
S
WR
Y
TFL
L
IA
VFN
I
A
V
M
A
S
V
YFW
V
P
DIRD
EA
K
G
K
L
-
R
EQFHF
LR
S
PA
PW
L
I
F
A
A
T
M
F
G
NA
G
V
F
A
W
F
SY
V
K
P
Y
M
M
F
I
S
G
F
S
ET
A
M
T
F
I
M
M
L
V
G
L
G
MV
L
GN
V
L
S
G
R
I
SG
RY
SPLRIA
A
VTD
F
II
VL
AL
LML
F
--
F
F
G
GM
K
TTSL
I
F
---
AFI
CC
A
G
L
FA
L
SA
PLQ
I
L
L
L
QN
A
KG
G
EL
L
GA
A
GGQ
I
AFNLG
S
A
V
GA
YC
GG
M
M
L
T
-
LGL
A
Y
N
Y
V
ALP
A
A
L
LS
FAA
M
S
-
SLL
L
Y
G
R
YKR
Q
fig|199310.1.peg.482
Escherichia coli CFT073 (33-409/422)
IL
S
LALG
T
FG
L
G
MA
EF
G
I
MG
V
L
TE
L
A
HN
V
G
I
SIPAAG
H
MIS
Y
YA
L
GV
V
VGAP
IIA
L
FS
S
RYS
LK
HI
L
L
FL
V
AL
C
VI
GN
AMF
T
LS
S
SY
LM
L
A
I
G
R
L
VSG
F
P
HGAFFG
V
GA
I
V
L
SK
I
I
K
P
GK
V
T
A
AVA
G
M
VS
G
M
T
V
AN
L
LG
I
PLGT
Y
L
S
Q
E
F
S
WR
Y
TFL
L
IA
VFN
I
A
V
M
A
S
V
YFW
V
P
DIRD
EA
K
G
K
L
-
R
EQFHF
LR
S
PA
PW
L
I
F
A
A
T
M
F
G
NA
G
V
F
A
W
F
SY
V
K
P
Y
M
M
F
I
S
G
F
S
ET
A
M
T
F
I
M
M
L
V
G
L
G
MV
L
GN
V
L
S
G
R
I
SG
RY
SPLRIA
A
VTD
F
II
VL
AL
LML
F
--
F
F
G
GM
K
TTSL
I
F
---
AFI
CC
A
G
L
FA
L
SA
PLQ
I
L
L
L
QN
A
KG
G
EL
L
GA
A
GGQ
I
AFNLG
S
A
V
GA
YC
GG
M
M
L
T
-
LGL
A
Y
N
Y
V
ALP
A
A
L
LS
FAA
M
S
-
SLL
L
Y
G
R
YKR
Q
fig|199310.4.peg.471
Escherichia coli CFT073 (33-409/422)
IL
S
LALG
T
FG
L
G
MA
EF
G
I
MG
V
L
TE
L
A
HN
V
G
I
SIPAAG
H
MIS
Y
YA
L
GV
V
VGAP
IIA
L
FS
S
RYS
LK
HI
L
L
FL
V
AL
C
VI
GN
AMF
T
LS
S
SY
LM
L
A
I
G
R
L
VSG
F
P
HGAFFG
V
GA
I
V
L
SK
I
I
K
P
GK
V
T
A
AVA
G
M
VS
G
M
T
V
AN
L
LG
I
PLGT
Y
L
S
Q
E
F
S
WR
Y
TFL
L
IA
VFN
I
A
V
M
A
S
V
YFW
V
P
DIRD
EA
K
G
K
L
-
R
EQFHF
LR
S
PA
PW
L
I
F
A
A
T
M
F
G
NA
G
V
F
A
W
F
SY
V
K
P
Y
M
M
F
I
S
G
F
S
ET
A
M
T
F
I
M
M
L
V
G
L
G
MV
L
GN
V
L
S
G
R
I
SG
RY
SPLRIA
A
VTD
F
II
VL
AL
LML
F
--
F
F
G
GM
K
TTSL
I
F
---
AFI
CC
A
G
L
FA
L
SA
PLQ
I
L
L
L
QN
A
KG
G
EL
L
GA
A
GGQ
I
AFNLG
S
A
V
GA
YC
GG
M
M
L
T
-
LGL
A
Y
N
Y
V
ALP
A
A
L
LS
FAA
M
S
-
SLL
L
Y
G
R
YKR
Q
fig|749546.3.peg.3499
Escherichia coli MS 185-1 (33-409/422)
IL
S
LALG
T
FG
L
G
MA
EF
G
I
MG
V
L
TE
L
A
HN
V
G
I
SIPAAG
H
MIS
Y
YA
L
GV
V
VGAP
IIA
L
FS
S
RYS
LK
HI
L
L
FL
V
AL
C
VI
GN
AMF
T
LS
S
SY
LM
L
A
I
G
R
L
VSG
F
P
HGAFFG
V
GA
I
V
L
SK
I
I
K
P
GK
V
T
A
AVA
G
M
VS
G
M
T
V
AN
L
LG
I
PLGT
Y
L
S
Q
E
F
S
WR
Y
TFL
L
IA
VFN
I
A
V
M
A
S
V
YFW
V
P
DIRD
EA
K
G
K
L
-
R
EQFHF
LR
S
PA
PW
L
I
F
A
A
T
M
F
G
NA
G
V
F
A
W
F
SY
V
K
P
Y
M
M
F
I
S
G
F
S
ET
A
M
T
F
I
M
M
L
V
G
L
G
MV
L
GN
V
L
S
G
R
I
SG
RY
SPLRIA
A
VTD
F
II
VL
AL
LML
F
--
F
F
G
GM
K
TTSL
I
F
---
AFI
CC
A
G
L
FA
L
SA
PLQ
I
L
L
L
QN
A
KG
G
EL
L
GA
A
GGQ
I
AFNLG
S
A
V
GA
YC
GG
M
M
L
T
-
LGL
A
Y
N
Y
V
ALP
A
A
L
LS
FAA
M
S
-
SLL
L
Y
G
R
YKR
Q
fig|749528.3.peg.3670
Escherichia coli MS 45-1 (33-409/422)
IL
S
LALG
T
FG
L
G
MA
EF
G
I
MG
V
L
TE
L
A
HN
V
G
I
SIPAAG
H
MIS
Y
YA
L
GV
V
VGAP
IIA
L
FS
S
RYS
LK
HI
L
L
FL
V
AL
C
VI
GN
AMF
T
LS
S
SY
LM
L
A
I
G
R
L
VSG
F
P
HGAFFG
V
GA
I
V
L
SK
I
I
K
P
GK
V
T
A
AVA
G
M
VS
G
M
T
V
AN
L
LG
I
PLGT
Y
L
S
Q
E
F
S
WR
Y
TFL
L
IA
VFN
I
A
V
M
A
S
V
YFW
V
P
DIRD
EA
K
G
K
L
-
R
EQFHF
LR
S
PA
PW
L
I
F
A
A
T
M
F
G
NA
G
V
F
A
W
F
SY
V
K
P
Y
M
M
F
I
S
G
F
S
ET
A
M
T
F
I
M
M
L
V
G
L
G
MV
L
GN
V
L
S
G
R
I
SG
RY
SPLRIA
A
VTD
F
II
VL
AL
LML
F
--
F
F
G
GM
K
TTSL
I
F
---
AFI
CC
A
G
L
FA
L
SA
PLQ
I
L
L
L
QN
A
KG
G
EL
L
GA
A
GGQ
I
AFNLG
S
A
V
GA
YC
GG
M
M
L
T
-
LGL
A
Y
N
Y
V
ALP
A
A
L
LS
FAA
M
S
-
SLL
L
Y
G
R
YKR
Q
fig|481805.3.peg.3470
Escherichia coli ATCC 8739 (5-381/394)
IL
S
LALG
T
FG
L
G
MA
EF
G
I
MG
V
L
TE
L
A
HN
V
G
I
SIPAAG
H
MIS
Y
YA
L
GV
V
VGAP
IIA
L
FS
S
RYS
LK
HI
L
L
FL
V
AL
C
VI
GN
AMF
T
LS
S
SY
LM
L
A
I
G
R
L
VSG
F
P
HGAFFG
V
GA
I
V
L
SK
I
I
K
P
GK
V
T
A
AVA
G
M
VS
G
M
T
V
AN
L
LG
I
PLGT
Y
L
S
Q
E
F
S
WR
Y
TFL
L
IA
VFN
I
A
V
M
A
S
V
YFW
V
P
DIRD
EA
K
G
N
L
-
R
EQFHF
LR
S
PA
PW
L
I
F
A
A
T
M
F
G
NA
G
V
F
A
W
F
SY
V
K
P
Y
M
M
F
I
S
G
F
S
ET
A
M
T
F
I
M
M
L
V
G
L
G
MV
L
GN
M
L
S
G
R
I
SG
RY
SPLRIA
A
VTD
F
II
VL
AL
LML
F
--
F
C
G
GM
K
TTSL
I
F
---
AFI
CC
A
G
L
FA
L
SA
PLQ
I
L
L
L
QN
A
KG
G
EL
L
GA
A
GGQ
I
AFNLG
S
A
V
GA
YC
GG
M
M
L
T
-
LGL
A
Y
N
Y
V
ALP
A
A
L
LS
FAA
M
S
-
SLL
L
Y
G
R
YKR
Q
fig|316407.3.peg.382
Escherichia coli W3110 (5-381/394)
IL
S
LALG
T
FG
L
G
MA
EF
G
I
MG
V
L
TE
L
A
HN
V
G
I
SIPAAG
H
MIS
Y
YA
L
GV
V
VGAP
IIA
L
FS
S
RYS
LK
HI
L
L
FL
V
AL
C
VI
GN
AMF
T
LS
S
SY
LM
L
A
I
G
R
L
VSG
F
P
HGAFFG
V
GA
I
V
L
SK
I
I
K
P
GK
V
T
A
AVA
G
M
VS
G
M
T
V
AN
L
LG
I
PLGT
Y
L
S
Q
E
F
S
WR
Y
TFL
L
IA
VFN
I
A
V
M
A
S
V
YFW
V
P
DIRD
EA
K
G
N
L
-
R
EQFHF
LR
S
PA
PW
L
I
F
A
A
T
M
F
G
NA
G
V
F
A
W
F
SY
V
K
P
Y
M
M
F
I
S
G
F
S
ET
A
M
T
F
I
M
M
L
V
G
L
G
MV
L
GN
M
L
S
G
R
I
SG
RY
SPLRIA
A
VTD
F
II
VL
AL
LML
F
--
F
C
G
GM
K
TTSL
I
F
---
AFI
CC
A
G
L
FA
L
SA
PLQ
I
L
L
L
QN
A
KG
G
EL
L
GA
A
GGQ
I
AFNLG
S
A
V
GA
YC
GG
M
M
L
T
-
LGL
A
Y
N
Y
V
ALP
A
A
L
LS
FAA
M
S
-
SLL
L
Y
G
R
YKR
Q
fig|656417.3.peg.526
Escherichia coli M605 (33-409/422)
IL
S
LALG
T
FG
L
G
MA
EF
G
I
MG
V
L
TE
L
A
HN
V
G
I
SIPAAG
H
MIS
Y
YA
L
GV
V
VGAP
IIA
L
FS
S
RYS
LK
HI
L
L
FL
V
AL
C
VI
GN
AMF
T
LS
S
SY
LM
L
A
I
G
R
L
VSG
F
P
HGAFFG
V
GA
I
V
L
SK
I
I
K
P
GK
V
T
A
AVA
G
M
VS
G
M
T
V
AN
L
LG
I
PLGT
Y
L
S
Q
E
F
S
WR
Y
TFL
L
IA
VFN
I
A
V
M
A
S
V
YFW
V
P
DIRD
EA
K
G
K
L
-
R
EQFHF
LR
S
PA
PW
L
I
F
A
A
T
M
F
G
NA
G
V
F
A
W
F
SY
V
K
P
Y
M
M
F
I
S
G
F
S
ET
A
M
T
F
I
M
M
L
V
G
L
G
MV
L
GN
M
L
S
G
R
I
SG
RY
SPLRIA
A
VTD
F
II
VL
AL
LML
F
--
F
F
G
GM
K
TTSL
I
F
---
AFI
CC
A
G
L
FA
L
SA
PLQ
I
L
L
L
QN
A
KG
G
EL
L
GA
A
GGQ
I
AFNLG
S
A
V
GA
YC
GG
M
M
L
T
-
LGL
A
Y
N
Y
V
ALP
A
A
L
LS
FAA
M
S
-
SLL
L
Y
G
R
YKR
Q
fig|753642.3.peg.1243
Escherichia coli NC101 (33-409/422)
IL
S
LALG
T
FG
L
G
MA
EF
G
I
MG
V
L
TE
L
A
HN
V
G
I
SIPAAG
H
MIS
Y
YA
L
GV
V
VGAP
IIA
L
FS
S
RYS
LK
HI
L
L
FL
V
AL
C
VI
GN
AMF
T
LS
S
SY
LM
L
A
I
G
R
L
VSG
F
P
HGAFFG
V
GA
I
V
L
SK
I
I
K
P
GK
V
T
A
AVA
G
M
VS
G
M
T
V
AN
L
LG
I
PLGT
Y
L
S
Q
E
F
S
WR
Y
TFL
L
IA
VFN
I
A
V
M
A
S
V
YFW
V
P
DIRD
EA
K
G
K
L
-
R
EQFHF
LR
S
PA
PW
L
I
F
A
A
T
M
F
G
NA
G
V
F
A
W
F
SY
V
K
P
Y
M
M
F
I
S
G
F
S
ET
A
M
T
F
I
M
M
L
V
G
L
G
MV
L
GN
M
L
S
G
R
I
SG
RY
SPLRIA
A
VTD
F
II
VL
AL
LML
F
--
F
F
G
GM
K
TTSL
I
F
---
AFI
CC
A
G
L
FA
L
SA
PLQ
I
L
L
L
QN
A
KG
G
EL
L
GA
A
GGQ
I
AFNLG
S
A
V
GA
YC
GG
M
M
L
T
-
LGL
A
Y
N
Y
V
ALP
A
A
L
LS
FAA
M
S
-
SLL
L
Y
G
R
YKR
Q
fig|685038.3.peg.370
Escherichia coli O83:H1 str. NRG 857C (33-409/422)
IL
S
LALG
T
FG
L
G
MA
EF
G
I
MG
V
L
TE
L
A
HN
V
G
I
SIPAAG
H
MIS
Y
YA
L
GV
V
VGAP
IIA
L
FS
S
RYS
LK
HI
L
L
FL
V
AL
C
VI
GN
AMF
T
LS
S
SY
LM
L
A
I
G
R
L
VSG
F
P
HGAFFG
V
GA
I
V
L
SK
I
I
K
P
GK
V
T
A
AVA
G
M
VS
G
M
T
V
AN
L
LG
I
PLGT
Y
L
S
Q
E
F
S
WR
Y
TFL
L
IA
VFN
I
A
V
M
A
S
V
YFW
V
P
DIRD
EA
K
G
K
L
-
R
EQFHF
LR
S
PA
PW
L
I
F
A
A
T
M
F
G
NA
G
V
F
A
W
F
SY
V
K
P
Y
M
M
F
I
S
G
F
S
ET
A
M
T
F
I
M
M
L
V
G
L
G
MV
L
GN
M
L
S
G
R
I
SG
RY
SPLRIA
A
VTD
F
II
VL
AL
LML
F
--
F
F
G
GM
K
TTSL
I
F
---
AFI
CC
A
G
L
FA
L
SA
PLQ
I
L
L
L
QN
A
KG
G
EL
L
GA
A
GGQ
I
AFNLG
S
A
V
GA
YC
GG
M
M
L
T
-
LGL
A
Y
N
Y
V
ALP
A
A
L
LS
FAA
M
S
-
SLL
L
Y
G
R
YKR
Q
fig|6666666.5357.peg.470
Escherichia coli TY-2482 (33-409/422)
IL
S
LALG
T
FG
L
G
MA
EF
G
I
MG
V
L
TE
L
A
HN
V
G
I
SIPAAG
H
MIS
Y
YA
L
GV
V
VGAP
IIA
L
FS
S
RYS
LK
HI
L
L
FL
V
AL
C
VI
GN
AMF
T
LS
S
SY
LM
L
A
I
G
R
L
VSG
F
P
HGAFFG
V
GA
I
V
L
SK
I
I
K
P
GK
V
T
A
AVA
G
M
VS
G
M
T
V
AN
L
LG
I
PLGT
Y
L
S
Q
E
F
S
WR
Y
TFL
L
IA
VFN
I
A
V
M
A
S
V
YFW
V
P
DIRD
EA
K
G
K
L
-
R
EQFHF
LR
S
PA
PW
L
I
F
A
A
T
M
F
G
NA
G
V
F
A
W
F
SY
V
K
P
Y
M
M
F
I
S
G
F
S
ET
A
M
T
F
I
M
M
L
V
G
L
G
MV
L
GN
M
L
S
G
R
I
SG
RY
SPLRIA
A
VTD
F
II
VL
AL
LML
F
--
F
C
G
GM
K
TTSL
I
F
---
AFI
CC
A
G
L
FA
L
SA
PLQ
I
L
L
L
QN
A
KG
G
EL
L
GA
A
GGQ
I
AFNLG
S
A
V
GA
YC
GG
M
M
L
T
-
LGL
A
Y
N
Y
V
ALP
A
A
L
LS
FAA
M
S
-
SLL
L
Y
G
R
YKR
Q
fig|562.371.peg.2635
Escherichia coli 1044A (33-409/422)
IL
S
LALG
T
FG
L
G
MA
EF
G
I
MG
V
L
TE
L
A
HN
V
G
I
SIPAAG
H
MIS
Y
YA
L
GV
V
VGAP
IIA
L
FS
S
RYS
LK
HI
L
L
FL
V
AL
C
VI
GN
AMF
T
LS
S
SY
LM
L
A
I
G
R
L
VSG
F
P
HGAFFG
V
GA
I
V
L
SK
I
I
K
P
GK
V
T
A
AVA
G
M
VS
G
M
T
V
AN
L
LG
I
PLGT
Y
L
S
Q
E
F
S
WR
Y
TFL
L
IA
VFN
I
A
V
M
A
S
V
YFW
V
P
DIRD
EA
K
G
K
L
-
R
EQFHF
LR
S
PA
PW
L
I
F
A
A
T
M
F
G
NA
G
V
F
A
W
F
SY
V
K
P
Y
M
M
F
I
S
G
F
S
ET
A
M
T
F
I
M
M
L
V
G
L
G
MV
L
GN
M
L
S
G
R
I
SG
RY
SPLRIA
A
VTD
F
II
VL
AL
LML
F
--
F
C
G
GM
K
TTSL
I
F
---
AFI
CC
A
G
L
FA
L
SA
PLQ
I
L
L
L
QN
A
KG
G
EL
L
GA
A
GGQ
I
AFNLG
S
A
V
GA
YC
GG
M
M
L
T
-
LGL
A
Y
N
Y
V
ALP
A
A
L
LS
FAA
M
S
-
SLL
L
Y
G
R
YKR
Q
fig|562.373.peg.3357
Escherichia coli 1125A (33-409/422)
IL
S
LALG
T
FG
L
G
MA
EF
G
I
MG
V
L
TE
L
A
HN
V
G
I
SIPAAG
H
MIS
Y
YA
L
GV
V
VGAP
IIA
L
FS
S
RYS
LK
HI
L
L
FL
V
AL
C
VI
GN
AMF
T
LS
S
SY
LM
L
A
I
G
R
L
VSG
F
P
HGAFFG
V
GA
I
V
L
SK
I
I
K
P
GK
V
T
A
AVA
G
M
VS
G
M
T
V
AN
L
LG
I
PLGT
Y
L
S
Q
E
F
S
WR
Y
TFL
L
IA
VFN
I
A
V
M
A
S
V
YFW
V
P
DIRD
EA
K
G
K
L
-
R
EQFHF
LR
S
PA
PW
L
I
F
A
A
T
M
F
G
NA
G
V
F
A
W
F
SY
V
K
P
Y
M
M
F
I
S
G
F
S
ET
A
M
T
F
I
M
M
L
V
G
L
G
MV
L
GN
M
L
S
G
R
I
SG
RY
SPLRIA
A
VTD
F
II
VL
AL
LML
F
--
F
C
G
GM
K
TTSL
I
F
---
AFI
CC
A
G
L
FA
L
SA
PLQ
I
L
L
L
QN
A
KG
G
EL
L
GA
A
GGQ
I
AFNLG
S
A
V
GA
YC
GG
M
M
L
T
-
LGL
A
Y
N
Y
V
ALP
A
A
L
LS
FAA
M
S
-
SLL
L
Y
G
R
YKR
Q
fig|562.372.peg.1370
Escherichia coli 1212A (33-409/422)
IL
S
LALG
T
FG
L
G
MA
EF
G
I
MG
V
L
TE
L
A
HN
V
G
I
SIPAAG
H
MIS
Y
YA
L
GV
V
VGAP
IIA
L
FS
S
RYS
LK
HI
L
L
FL
V
AL
C
VI
GN
AMF
T
LS
S
SY
LM
L
A
I
G
R
L
VSG
F
P
HGAFFG
V
GA
I
V
L
SK
I
I
K
P
GK
V
T
A
AVA
G
M
VS
G
M
T
V
AN
L
LG
I
PLGT
Y
L
S
Q
E
F
S
WR
Y
TFL
L
IA
VFN
I
A
V
M
A
S
V
YFW
V
P
DIRD
EA
K
G
K
L
-
R
EQFHF
LR
S
PA
PW
L
I
F
A
A
T
M
F
G
NA
G
V
F
A
W
F
SY
V
K
P
Y
M
M
F
I
S
G
F
S
ET
A
M
T
F
I
M
M
L
V
G
L
G
MV
L
GN
M
L
S
G
R
I
SG
RY
SPLRIA
A
VTD
F
II
VL
AL
LML
F
--
F
C
G
GM
K
TTSL
I
F
---
AFI
CC
A
G
L
FA
L
SA
PLQ
I
L
L
L
QN
A
KG
G
EL
L
GA
A
GGQ
I
AFNLG
S
A
V
GA
YC
GG
M
M
L
T
-
LGL
A
Y
N
Y
V
ALP
A
A
L
LS
FAA
M
S
-
SLL
L
Y
G
R
YKR
Q
fig|562.374.peg.5608
Escherichia coli 536A (33-409/422)
IL
S
LALG
T
FG
L
G
MA
EF
G
I
MG
V
L
TE
L
A
HN
V
G
I
SIPAAG
H
MIS
Y
YA
L
GV
V
VGAP
IIA
L
FS
S
RYS
LK
HI
L
L
FL
V
AL
C
VI
GN
AMF
T
LS
S
SY
LM
L
A
I
G
R
L
VSG
F
P
HGAFFG
V
GA
I
V
L
SK
I
I
K
P
GK
V
T
A
AVA
G
M
VS
G
M
T
V
AN
L
LG
I
PLGT
Y
L
S
Q
E
F
S
WR
Y
TFL
L
IA
VFN
I
A
V
M
A
S
V
YFW
V
P
DIRD
EA
K
G
K
L
-
R
EQFHF
LR
S
PA
PW
L
I
F
A
A
T
M
F
G
NA
G
V
F
A
W
F
SY
V
K
P
Y
M
M
F
I
S
G
F
S
ET
A
M
T
F
I
M
M
L
V
G
L
G
MV
L
GN
M
L
S
G
R
I
SG
RY
SPLRIA
A
VTD
F
II
VL
AL
LML
F
--
F
C
G
GM
K
TTSL
I
F
---
AFI
CC
A
G
L
FA
L
SA
PLQ
I
L
L
L
QN
A
KG
G
EL
L
GA
A
GGQ
I
AFNLG
S
A
V
GA
YC
GG
M
M
L
T
-
LGL
A
Y
N
Y
V
ALP
A
A
L
LS
FAA
M
S
-
SLL
L
Y
G
R
YKR
Q
fig|585055.6.peg.409
Escherichia coli 55989 (33-409/422)
IL
S
LALG
T
FG
L
G
MA
EF
G
I
MG
V
L
TE
L
A
HN
V
G
I
SIPAAG
H
MIS
Y
YA
L
GV
V
VGAP
IIA
L
FS
S
RYS
LK
HI
L
L
FL
V
AL
C
VI
GN
AMF
T
LS
S
SY
LM
L
A
I
G
R
L
VSG
F
P
HGAFFG
V
GA
I
V
L
SK
I
I
K
P
GK
V
T
A
AVA
G
M
VS
G
M
T
V
AN
L
LG
I
PLGT
Y
L
S
Q
E
F
S
WR
Y
TFL
L
IA
VFN
I
A
V
M
A
S
V
YFW
V
P
DIRD
EA
K
G
K
L
-
R
EQFHF
LR
S
PA
PW
L
I
F
A
A
T
M
F
G
NA
G
V
F
A
W
F
SY
V
K
P
Y
M
M
F
I
S
G
F
S
ET
A
M
T
F
I
M
M
L
V
G
L
G
MV
L
GN
M
L
S
G
R
I
SG
RY
SPLRIA
A
VTD
F
II
VL
AL
LML
F
--
F
C
G
GM
K
TTSL
I
F
---
AFI
CC
A
G
L
FA
L
SA
PLQ
I
L
L
L
QN
A
KG
G
EL
L
GA
A
GGQ
I
AFNLG
S
A
V
GA
YC
GG
M
M
L
T
-
LGL
A
Y
N
Y
V
ALP
A
A
L
LS
FAA
M
S
-
SLL
L
Y
G
R
YKR
Q
fig|585055.8.peg.410
Escherichia coli 55989 (33-409/422)
IL
S
LALG
T
FG
L
G
MA
EF
G
I
MG
V
L
TE
L
A
HN
V
G
I
SIPAAG
H
MIS
Y
YA
L
GV
V
VGAP
IIA
L
FS
S
RYS
LK
HI
L
L
FL
V
AL
C
VI
GN
AMF
T
LS
S
SY
LM
L
A
I
G
R
L
VSG
F
P
HGAFFG
V
GA
I
V
L
SK
I
I
K
P
GK
V
T
A
AVA
G
M
VS
G
M
T
V
AN
L
LG
I
PLGT
Y
L
S
Q
E
F
S
WR
Y
TFL
L
IA
VFN
I
A
V
M
A
S
V
YFW
V
P
DIRD
EA
K
G
K
L
-
R
EQFHF
LR
S
PA
PW
L
I
F
A
A
T
M
F
G
NA
G
V
F
A
W
F
SY
V
K
P
Y
M
M
F
I
S
G
F
S
ET
A
M
T
F
I
M
M
L
V
G
L
G
MV
L
GN
M
L
S
G
R
I
SG
RY
SPLRIA
A
VTD
F
II
VL
AL
LML
F
--
F
C
G
GM
K
TTSL
I
F
---
AFI
CC
A
G
L
FA
L
SA
PLQ
I
L
L
L
QN
A
KG
G
EL
L
GA
A
GGQ
I
AFNLG
S
A
V
GA
YC
GG
M
M
L
T
-
LGL
A
Y
N
Y
V
ALP
A
A
L
LS
FAA
M
S
-
SLL
L
Y
G
R
YKR
Q
fig|340186.5.peg.1869
Escherichia coli E110019 (33-409/422)
IL
S
LALG
T
FG
L
G
MA
EF
G
I
MG
V
L
TE
L
A
HN
V
G
I
SIPAAG
H
MIS
Y
YA
L
GV
V
VGAP
IIA
L
FS
S
RYS
LK
HI
L
L
FL
V
AL
C
VI
GN
AMF
T
LS
S
SY
LM
L
A
I
G
R
L
VSG
F
P
HGAFFG
V
GA
I
V
L
SK
I
I
K
P
GK
V
T
A
AVA
G
M
VS
G
M
T
V
AN
L
LG
I
PLGT
Y
L
S
Q
E
F
S
WR
Y
TFL
L
IA
VFN
I
A
V
M
A
S
V
YFW
V
P
DIRD
EA
K
G
K
L
-
R
EQFHF
LR
S
PA
PW
L
I
F
A
A
T
M
F
G
NA
G
V
F
A
W
F
SY
V
K
P
Y
M
M
F
I
S
G
F
S
ET
A
M
T
F
I
M
M
L
V
G
L
G
MV
L
GN
M
L
S
G
R
I
SG
RY
SPLRIA
A
VTD
F
II
VL
AL
LML
F
--
F
C
G
GM
K
TTSL
I
F
---
AFI
CC
A
G
L
FA
L
SA
PLQ
I
L
L
L
QN
A
KG
G
EL
L
GA
A
GGQ
I
AFNLG
S
A
V
GA
YC
GG
M
M
L
T
-
LGL
A
Y
N
Y
V
ALP
A
A
L
LS
FAA
M
S
-
SLL
L
Y
G
R
YKR
Q
fig|331111.12.peg.732
Escherichia coli E24377A (33-409/422)
IL
S
LALG
T
FG
L
G
MA
EF
G
I
MG
V
L
TE
L
A
HN
V
G
I
SIPAAG
H
MIS
Y
YA
L
GV
V
VGAP
IIA
L
FS
S
RYS
LK
HI
L
L
FL
V
AL
C
VI
GN
AMF
T
LS
S
SY
LM
L
A
I
G
R
L
VSG
F
P
HGAFFG
V
GA
I
V
L
SK
I
I
K
P
GK
V
T
A
AVA
G
M
VS
G
M
T
V
AN
L
LG
I
PLGT
Y
L
S
Q
E
F
S
WR
Y
TFL
L
IA
VFN
I
A
V
M
A
S
V
YFW
V
P
DIRD
EA
K
G
K
L
-
R
EQFHF
LR
S
PA
PW
L
I
F
A
A
T
M
F
G
NA
G
V
F
A
W
F
SY
V
K
P
Y
M
M
F
I
S
G
F
S
ET
A
M
T
F
I
M
M
L
V
G
L
G
MV
L
GN
M
L
S
G
R
I
SG
RY
SPLRIA
A
VTD
F
II
VL
AL
LML
F
--
F
C
G
GM
K
TTSL
I
F
---
AFI
CC
A
G
L
FA
L
SA
PLQ
I
L
L
L
QN
A
KG
G
EL
L
GA
A
GGQ
I
AFNLG
S
A
V
GA
YC
GG
M
M
L
T
-
LGL
A
Y
N
Y
V
ALP
A
A
L
LS
FAA
M
S
-
SLL
L
Y
G
R
YKR
Q
fig|562.375.peg.3665
Escherichia coli EC4100B (33-409/422)
IL
S
LALG
T
FG
L
G
MA
EF
G
I
MG
V
L
TE
L
A
HN
V
G
I
SIPAAG
H
MIS
Y
YA
L
GV
V
VGAP
IIA
L
FS
S
RYS
LK
HI
L
L
FL
V
AL
C
VI
GN
AMF
T
LS
S
SY
LM
L
A
I
G
R
L
VSG
F
P
HGAFFG
V
GA
I
V
L
SK
I
I
K
P
GK
V
T
A
AVA
G
M
VS
G
M
T
V
AN
L
LG
I
PLGT
Y
L
S
Q
E
F
S
WR
Y
TFL
L
IA
VFN
I
A
V
M
A
S
V
YFW
V
P
DIRD
EA
K
G
K
L
-
R
EQFHF
LR
S
PA
PW
L
I
F
A
A
T
M
F
G
NA
G
V
F
A
W
F
SY
V
K
P
Y
M
M
F
I
S
G
F
S
ET
A
M
T
F
I
M
M
L
V
G
L
G
MV
L
GN
M
L
S
G
R
I
SG
RY
SPLRIA
A
VTD
F
II
VL
AL
LML
F
--
F
C
G
GM
K
TTSL
I
F
---
AFI
CC
A
G
L
FA
L
SA
PLQ
I
L
L
L
QN
A
KG
G
EL
L
GA
A
GGQ
I
AFNLG
S
A
V
GA
YC
GG
M
M
L
T
-
LGL
A
Y
N
Y
V
ALP
A
A
L
LS
FAA
M
S
-
SLL
L
Y
G
R
YKR
Q
fig|656408.3.peg.327
Escherichia coli H591 (33-409/422)
IL
S
LALG
T
FG
L
G
MA
EF
G
I
MG
V
L
TE
L
A
HN
V
G
I
SIPAAG
H
MIS
Y
YA
L
GV
V
VGAP
IIA
L
FS
S
RYS
LK
HI
L
L
FL
V
AL
C
VI
GN
AMF
T
LS
S
SY
LM
L
A
I
G
R
L
VSG
F
P
HGAFFG
V
GA
I
V
L
SK
I
I
K
P
GK
V
T
A
AVA
G
M
VS
G
M
T
V
AN
L
LG
I
PLGT
Y
L
S
Q
E
F
S
WR
Y
TFL
L
IA
VFN
I
A
V
M
A
S
V
YFW
V
P
DIRD
EA
K
G
K
L
-
R
EQFHF
LR
S
PA
PW
L
I
F
A
A
T
M
F
G
NA
G
V
F
A
W
F
SY
V
K
P
Y
M
M
F
I
S
G
F
S
ET
A
M
T
F
I
M
M
L
V
G
L
G
MV
L
GN
M
L
S
G
R
I
SG
RY
SPLRIA
A
VTD
F
II
VL
AL
LML
F
--
F
C
G
GM
K
TTSL
I
F
---
AFI
CC
A
G
L
FA
L
SA
PLQ
I
L
L
L
QN
A
KG
G
EL
L
GA
A
GGQ
I
AFNLG
S
A
V
GA
YC
GG
M
M
L
T
-
LGL
A
Y
N
Y
V
ALP
A
A
L
LS
FAA
M
S
-
SLL
L
Y
G
R
YKR
Q
fig|331112.6.peg.452
Escherichia coli HS (33-409/422)
IL
S
LALG
T
FG
L
G
MA
EF
G
I
MG
V
L
TE
L
A
HN
V
G
I
SIPAAG
H
MIS
Y
YA
L
GV
V
VGAP
IIA
L
FS
S
RYS
LK
HI
L
L
FL
V
AL
C
VI
GN
AMF
T
LS
S
SY
LM
L
A
I
G
R
L
VSG
F
P
HGAFFG
V
GA
I
V
L
SK
I
I
K
P
GK
V
T
A
AVA
G
M
VS
G
M
T
V
AN
L
LG
I
PLGT
Y
L
S
Q
E
F
S
WR
Y
TFL
L
IA
VFN
I
A
V
M
A
S
V
YFW
V
P
DIRD
EA
K
G
K
L
-
R
EQFHF
LR
S
PA
PW
L
I
F
A
A
T
M
F
G
NA
G
V
F
A
W
F
SY
V
K
P
Y
M
M
F
I
S
G
F
S
ET
A
M
T
F
I
M
M
L
V
G
L
G
MV
L
GN
M
L
S
G
R
I
SG
RY
SPLRIA
A
VTD
F
II
VL
AL
LML
F
--
F
C
G
GM
K
TTSL
I
F
---
AFI
CC
A
G
L
FA
L
SA
PLQ
I
L
L
L
QN
A
KG
G
EL
L
GA
A
GGQ
I
AFNLG
S
A
V
GA
YC
GG
M
M
L
T
-
LGL
A
Y
N
Y
V
ALP
A
A
L
LS
FAA
M
S
-
SLL
L
Y
G
R
YKR
Q
fig|749537.3.peg.1917
Escherichia coli MS 115-1 (33-409/422)
IL
S
LALG
T
FG
L
G
MA
EF
G
I
MG
V
L
TE
L
A
HN
V
G
I
SIPAAG
H
MIS
Y
YA
L
GV
V
VGAP
IIA
L
FS
S
RYS
LK
HI
L
L
FL
V
AL
C
VI
GN
AMF
T
LS
S
SY
LM
L
A
I
G
R
L
VSG
F
P
HGAFFG
V
GA
I
V
L
SK
I
I
K
P
GK
V
T
A
AVA
G
M
VS
G
M
T
V
AN
L
LG
I
PLGT
Y
L
S
Q
E
F
S
WR
Y
TFL
L
IA
VFN
I
A
V
M
A
S
V
YFW
V
P
DIRD
EA
K
G
K
L
-
R
EQFHF
LR
S
PA
PW
L
I
F
A
A
T
M
F
G
NA
G
V
F
A
W
F
SY
V
K
P
Y
M
M
F
I
S
G
F
S
ET
A
M
T
F
I
M
M
L
V
G
L
G
MV
L
GN
M
L
S
G
R
I
SG
RY
SPLRIA
A
VTD
F
II
VL
AL
LML
F
--
F
C
G
GM
K
TTSL
I
F
---
AFI
CC
A
G
L
FA
L
SA
PLQ
I
L
L
L
QN
A
KG
G
EL
L
GA
A
GGQ
I
AFNLG
S
A
V
GA
YC
GG
M
M
L
T
-
LGL
A
Y
N
Y
V
ALP
A
A
L
LS
FAA
M
S
-
SLL
L
Y
G
R
YKR
Q
fig|679206.4.peg.160
Escherichia coli MS 119-7 (33-409/422)
IL
S
LALG
T
FG
L
G
MA
EF
G
I
MG
V
L
TE
L
A
HN
V
G
I
SIPAAG
H
MIS
Y
YA
L
GV
V
VGAP
IIA
L
FS
S
RYS
LK
HI
L
L
FL
V
AL
C
VI
GN
AMF
T
LS
S
SY
LM
L
A
I
G
R
L
VSG
F
P
HGAFFG
V
GA
I
V
L
SK
I
I
K
P
GK
V
T
A
AVA
G
M
VS
G
M
T
V
AN
L
LG
I
PLGT
Y
L
S
Q
E
F
S
WR
Y
TFL
L
IA
VFN
I
A
V
M
A
S
V
YFW
V
P
DIRD
EA
K
G
K
L
-
R
EQFHF
LR
S
PA
PW
L
I
F
A
A
T
M
F
G
NA
G
V
F
A
W
F
SY
V
K
P
Y
M
M
F
I
S
G
F
S
ET
A
M
T
F
I
M
M
L
V
G
L
G
MV
L
GN
M
L
S
G
R
I
SG
RY
SPLRIA
A
VTD
F
II
VL
AL
LML
F
--
F
C
G
GM
K
TTSL
I
F
---
AFI
CC
A
G
L
FA
L
SA
PLQ
I
L
L
L
QN
A
KG
G
EL
L
GA
A
GGQ
I
AFNLG
S
A
V
GA
YC
GG
M
M
L
T
-
LGL
A
Y
N
Y
V
ALP
A
A
L
LS
FAA
M
S
-
SLL
L
Y
G
R
YKR
Q
fig|83334.1.peg.523
Escherichia coli O157:H7 (33-409/422)
IL
S
LALG
T
FG
L
G
MA
EF
G
I
MG
V
L
TE
L
A
HN
V
G
I
SIPAAG
H
MIS
Y
YA
L
GV
V
VGAP
IIA
L
FS
S
RYS
LK
HI
L
L
FL
V
AL
C
VI
GN
AMF
T
LS
S
SY
LM
L
A
I
G
R
L
VSG
F
P
HGAFFG
V
GA
I
V
L
SK
I
I
K
P
GK
V
T
A
AVA
G
M
VS
G
M
T
V
AN
L
LG
I
PLGT
Y
L
S
Q
E
F
S
WR
Y
TFL
L
IA
VFN
I
A
V
M
A
S
V
YFW
V
P
DIRD
EA
K
G
K
L
-
R
EQFHF
LR
S
PA
PW
L
I
F
A
A
T
M
F
G
NA
G
V
F
A
W
F
SY
V
K
P
Y
M
M
F
I
S
G
F
S
ET
A
M
T
F
I
M
M
L
V
G
L
G
MV
L
GN
M
L
S
G
R
I
SG
RY
SPLRIA
A
VTD
F
II
VL
AL
LML
F
--
F
C
G
GM
K
TTSL
I
F
---
AFI
CC
A
G
L
FA
L
SA
PLQ
I
L
L
L
QN
A
KG
G
EL
L
GA
A
GGQ
I
AFNLG
S
A
V
GA
YC
GG
M
M
L
T
-
LGL
A
Y
N
Y
V
ALP
A
A
L
LS
FAA
M
S
-
SLL
L
Y
G
R
YKR
Q
fig|155864.8.peg.442
Escherichia coli O157:H7 EDL933 (33-409/422)
IL
S
LALG
T
FG
L
G
MA
EF
G
I
MG
V
L
TE
L
A
HN
V
G
I
SIPAAG
H
MIS
Y
YA
L
GV
V
VGAP
IIA
L
FS
S
RYS
LK
HI
L
L
FL
V
AL
C
VI
GN
AMF
T
LS
S
SY
LM
L
A
I
G
R
L
VSG
F
P
HGAFFG
V
GA
I
V
L
SK
I
I
K
P
GK
V
T
A
AVA
G
M
VS
G
M
T
V
AN
L
LG
I
PLGT
Y
L
S
Q
E
F
S
WR
Y
TFL
L
IA
VFN
I
A
V
M
A
S
V
YFW
V
P
DIRD
EA
K
G
K
L
-
R
EQFHF
LR
S
PA
PW
L
I
F
A
A
T
M
F
G
NA
G
V
F
A
W
F
SY
V
K
P
Y
M
M
F
I
S
G
F
S
ET
A
M
T
F
I
M
M
L
V
G
L
G
MV
L
GN
M
L
S
G
R
I
SG
RY
SPLRIA
A
VTD
F
II
VL
AL
LML
F
--
F
C
G
GM
K
TTSL
I
F
---
AFI
CC
A
G
L
FA
L
SA
PLQ
I
L
L
L
QN
A
KG
G
EL
L
GA
A
GGQ
I
AFNLG
S
A
V
GA
YC
GG
M
M
L
T
-
LGL
A
Y
N
Y
V
ALP
A
A
L
LS
FAA
M
S
-
SLL
L
Y
G
R
YKR
Q
fig|444454.5.peg.4913
Escherichia coli O157:H7 str. EC4024 (33-409/422)
IL
S
LALG
T
FG
L
G
MA
EF
G
I
MG
V
L
TE
L
A
HN
V
G
I
SIPAAG
H
MIS
Y
YA
L
GV
V
VGAP
IIA
L
FS
S
RYS
LK
HI
L
L
FL
V
AL
C
VI
GN
AMF
T
LS
S
SY
LM
L
A
I
G
R
L
VSG
F
P
HGAFFG
V
GA
I
V
L
SK
I
I
K
P
GK
V
T
A
AVA
G
M
VS
G
M
T
V
AN
L
LG
I
PLGT
Y
L
S
Q
E
F
S
WR
Y
TFL
L
IA
VFN
I
A
V
M
A
S
V
YFW
V
P
DIRD
EA
K
G
K
L
-
R
EQFHF
LR
S
PA
PW
L
I
F
A
A
T
M
F
G
NA
G
V
F
A
W
F
SY
V
K
P
Y
M
M
F
I
S
G
F
S
ET
A
M
T
F
I
M
M
L
V
G
L
G
MV
L
GN
M
L
S
G
R
I
SG
RY
SPLRIA
A
VTD
F
II
VL
AL
LML
F
--
F
C
G
GM
K
TTSL
I
F
---
AFI
CC
A
G
L
FA
L
SA
PLQ
I
L
L
L
QN
A
KG
G
EL
L
GA
A
GGQ
I
AFNLG
S
A
V
GA
YC
GG
M
M
L
T
-
LGL
A
Y
N
Y
V
ALP
A
A
L
LS
FAA
M
S
-
SLL
L
Y
G
R
YKR
Q
fig|444449.5.peg.5253
Escherichia coli O157:H7 str. EC4042 (33-409/422)
IL
S
LALG
T
FG
L
G
MA
EF
G
I
MG
V
L
TE
L
A
HN
V
G
I
SIPAAG
H
MIS
Y
YA
L
GV
V
VGAP
IIA
L
FS
S
RYS
LK
HI
L
L
FL
V
AL
C
VI
GN
AMF
T
LS
S
SY
LM
L
A
I
G
R
L
VSG
F
P
HGAFFG
V
GA
I
V
L
SK
I
I
K
P
GK
V
T
A
AVA
G
M
VS
G
M
T
V
AN
L
LG
I
PLGT
Y
L
S
Q
E
F
S
WR
Y
TFL
L
IA
VFN
I
A
V
M
A
S
V
YFW
V
P
DIRD
EA
K
G
K
L
-
R
EQFHF
LR
S
PA
PW
L
I
F
A
A
T
M
F
G
NA
G
V
F
A
W
F
SY
V
K
P
Y
M
M
F
I
S
G
F
S
ET
A
M
T
F
I
M
M
L
V
G
L
G
MV
L
GN
M
L
S
G
R
I
SG
RY
SPLRIA
A
VTD
F
II
VL
AL
LML
F
--
F
C
G
GM
K
TTSL
I
F
---
AFI
CC
A
G
L
FA
L
SA
PLQ
I
L
L
L
QN
A
KG
G
EL
L
GA
A
GGQ
I
AFNLG
S
A
V
GA
YC
GG
M
M
L
T
-
LGL
A
Y
N
Y
V
ALP
A
A
L
LS
FAA
M
S
-
SLL
L
Y
G
R
YKR
Q
fig|444448.5.peg.3129
Escherichia coli O157:H7 str. EC4045 (33-409/422)
IL
S
LALG
T
FG
L
G
MA
EF
G
I
MG
V
L
TE
L
A
HN
V
G
I
SIPAAG
H
MIS
Y
YA
L
GV
V
VGAP
IIA
L
FS
S
RYS
LK
HI
L
L
FL
V
AL
C
VI
GN
AMF
T
LS
S
SY
LM
L
A
I
G
R
L
VSG
F
P
HGAFFG
V
GA
I
V
L
SK
I
I
K
P
GK
V
T
A
AVA
G
M
VS
G
M
T
V
AN
L
LG
I
PLGT
Y
L
S
Q
E
F
S
WR
Y
TFL
L
IA
VFN
I
A
V
M
A
S
V
YFW
V
P
DIRD
EA
K
G
K
L
-
R
EQFHF
LR
S
PA
PW
L
I
F
A
A
T
M
F
G
NA
G
V
F
A
W
F
SY
V
K
P
Y
M
M
F
I
S
G
F
S
ET
A
M
T
F
I
M
M
L
V
G
L
G
MV
L
GN
M
L
S
G
R
I
SG
RY
SPLRIA
A
VTD
F
II
VL
AL
LML
F
--
F
C
G
GM
K
TTSL
I
F
---
AFI
CC
A
G
L
FA
L
SA
PLQ
I
L
L
L
QN
A
KG
G
EL
L
GA
A
GGQ
I
AFNLG
S
A
V
GA
YC
GG
M
M
L
T
-
LGL
A
Y
N
Y
V
ALP
A
A
L
LS
FAA
M
S
-
SLL
L
Y
G
R
YKR
Q
fig|444453.5.peg.4538
Escherichia coli O157:H7 str. EC4076 (33-409/422)
IL
S
LALG
T
FG
L
G
MA
EF
G
I
MG
V
L
TE
L
A
HN
V
G
I
SIPAAG
H
MIS
Y
YA
L
GV
V
VGAP
IIA
L
FS
S
RYS
LK
HI
L
L
FL
V
AL
C
VI
GN
AMF
T
LS
S
SY
LM
L
A
I
G
R
L
VSG
F
P
HGAFFG
V
GA
I
V
L
SK
I
I
K
P
GK
V
T
A
AVA
G
M
VS
G
M
T
V
AN
L
LG
I
PLGT
Y
L
S
Q
E
F
S
WR
Y
TFL
L
IA
VFN
I
A
V
M
A
S
V
YFW
V
P
DIRD
EA
K
G
K
L
-
R
EQFHF
LR
S
PA
PW
L
I
F
A
A
T
M
F
G
NA
G
V
F
A
W
F
SY
V
K
P
Y
M
M
F
I
S
G
F
S
ET
A
M
T
F
I
M
M
L
V
G
L
G
MV
L
GN
M
L
S
G
R
I
SG
RY
SPLRIA
A
VTD
F
II
VL
AL
LML
F
--
F
C
G
GM
K
TTSL
I
F
---
AFI
CC
A
G
L
FA
L
SA
PLQ
I
L
L
L
QN
A
KG
G
EL
L
GA
A
GGQ
I
AFNLG
S
A
V
GA
YC
GG
M
M
L
T
-
LGL
A
Y
N
Y
V
ALP
A
A
L
LS
FAA
M
S
-
SLL
L
Y
G
R
YKR
Q
fig|444452.5.peg.2834
Escherichia coli O157:H7 str. EC4113 (33-409/422)
IL
S
LALG
T
FG
L
G
MA
EF
G
I
MG
V
L
TE
L
A
HN
V
G
I
SIPAAG
H
MIS
Y
YA
L
GV
V
VGAP
IIA
L
FS
S
RYS
LK
HI
L
L
FL
V
AL
C
VI
GN
AMF
T
LS
S
SY
LM
L
A
I
G
R
L
VSG
F
P
HGAFFG
V
GA
I
V
L
SK
I
I
K
P
GK
V
T
A
AVA
G
M
VS
G
M
T
V
AN
L
LG
I
PLGT
Y
L
S
Q
E
F
S
WR
Y
TFL
L
IA
VFN
I
A
V
M
A
S
V
YFW
V
P
DIRD
EA
K
G
K
L
-
R
EQFHF
LR
S
PA
PW
L
I
F
A
A
T
M
F
G
NA
G
V
F
A
W
F
SY
V
K
P
Y
M
M
F
I
S
G
F
S
ET
A
M
T
F
I
M
M
L
V
G
L
G
MV
L
GN
M
L
S
G
R
I
SG
RY
SPLRIA
A
VTD
F
II
VL
AL
LML
F
--
F
C
G
GM
K
TTSL
I
F
---
AFI
CC
A
G
L
FA
L
SA
PLQ
I
L
L
L
QN
A
KG
G
EL
L
GA
A
GGQ
I
AFNLG
S
A
V
GA
YC
GG
M
M
L
T
-
LGL
A
Y
N
Y
V
ALP
A
A
L
LS
FAA
M
S
-
SLL
L
Y
G
R
YKR
Q
fig|444450.8.peg.591
Escherichia coli O157:H7 str. EC4115 (33-409/422)
IL
S
LALG
T
FG
L
G
MA
EF
G
I
MG
V
L
TE
L
A
HN
V
G
I
SIPAAG
H
MIS
Y
YA
L
GV
V
VGAP
IIA
L
FS
S
RYS
LK
HI
L
L
FL
V
AL
C
VI
GN
AMF
T
LS
S
SY
LM
L
A
I
G
R
L
VSG
F
P
HGAFFG
V
GA
I
V
L
SK
I
I
K
P
GK
V
T
A
AVA
G
M
VS
G
M
T
V
AN
L
LG
I
PLGT
Y
L
S
Q
E
F
S
WR
Y
TFL
L
IA
VFN
I
A
V
M
A
S
V
YFW
V
P
DIRD
EA
K
G
K
L
-
R
EQFHF
LR
S
PA
PW
L
I
F
A
A
T
M
F
G
NA
G
V
F
A
W
F
SY
V
K
P
Y
M
M
F
I
S
G
F
S
ET
A
M
T
F
I
M
M
L
V
G
L
G
MV
L
GN
M
L
S
G
R
I
SG
RY
SPLRIA
A
VTD
F
II
VL
AL
LML
F
--
F
C
G
GM
K
TTSL
I
F
---
AFI
CC
A
G
L
FA
L
SA
PLQ
I
L
L
L
QN
A
KG
G
EL
L
GA
A
GGQ
I
AFNLG
S
A
V
GA
YC
GG
M
M
L
T
-
LGL
A
Y
N
Y
V
ALP
A
A
L
LS
FAA
M
S
-
SLL
L
Y
G
R
YKR
Q
fig|444451.5.peg.3824
Escherichia coli O157:H7 str. EC4196 (33-409/422)
IL
S
LALG
T
FG
L
G
MA
EF
G
I
MG
V
L
TE
L
A
HN
V
G
I
SIPAAG
H
MIS
Y
YA
L
GV
V
VGAP
IIA
L
FS
S
RYS
LK
HI
L
L
FL
V
AL
C
VI
GN
AMF
T
LS
S
SY
LM
L
A
I
G
R
L
VSG
F
P
HGAFFG
V
GA
I
V
L
SK
I
I
K
P
GK
V
T
A
AVA
G
M
VS
G
M
T
V
AN
L
LG
I
PLGT
Y
L
S
Q
E
F
S
WR
Y
TFL
L
IA
VFN
I
A
V
M
A
S
V
YFW
V
P
DIRD
EA
K
G
K
L
-
R
EQFHF
LR
S
PA
PW
L
I
F
A
A
T
M
F
G
NA
G
V
F
A
W
F
SY
V
K
P
Y
M
M
F
I
S
G
F
S
ET
A
M
T
F
I
M
M
L
V
G
L
G
MV
L
GN
M
L
S
G
R
I
SG
RY
SPLRIA
A
VTD
F
II
VL
AL
LML
F
--
F
C
G
GM
K
TTSL
I
F
---
AFI
CC
A
G
L
FA
L
SA
PLQ
I
L
L
L
QN
A
KG
G
EL
L
GA
A
GGQ
I
AFNLG
S
A
V
GA
YC
GG
M
M
L
T
-
LGL
A
Y
N
Y
V
ALP
A
A
L
LS
FAA
M
S
-
SLL
L
Y
G
R
YKR
Q
fig|444447.5.peg.3299
Escherichia coli O157:H7 str. EC4206 (33-409/422)
IL
S
LALG
T
FG
L
G
MA
EF
G
I
MG
V
L
TE
L
A
HN
V
G
I
SIPAAG
H
MIS
Y
YA
L
GV
V
VGAP
IIA
L
FS
S
RYS
LK
HI
L
L
FL
V
AL
C
VI
GN
AMF
T
LS
S
SY
LM
L
A
I
G
R
L
VSG
F
P
HGAFFG
V
GA
I
V
L
SK
I
I
K
P
GK
V
T
A
AVA
G
M
VS
G
M
T
V
AN
L
LG
I
PLGT
Y
L
S
Q
E
F
S
WR
Y
TFL
L
IA
VFN
I
A
V
M
A
S
V
YFW
V
P
DIRD
EA
K
G
K
L
-
R
EQFHF
LR
S
PA
PW
L
I
F
A
A
T
M
F
G
NA
G
V
F
A
W
F
SY
V
K
P
Y
M
M
F
I
S
G
F
S
ET
A
M
T
F
I
M
M
L
V
G
L
G
MV
L
GN
M
L
S
G
R
I
SG
RY
SPLRIA
A
VTD
F
II
VL
AL
LML
F
--
F
C
G
GM
K
TTSL
I
F
---
AFI
CC
A
G
L
FA
L
SA
PLQ
I
L
L
L
QN
A
KG
G
EL
L
GA
A
GGQ
I
AFNLG
S
A
V
GA
YC
GG
M
M
L
T
-
LGL
A
Y
N
Y
V
ALP
A
A
L
LS
FAA
M
S
-
SLL
L
Y
G
R
YKR
Q
fig|478004.5.peg.3622
Escherichia coli O157:H7 str. EC4401 (33-409/422)
IL
S
LALG
T
FG
L
G
MA
EF
G
I
MG
V
L
TE
L
A
HN
V
G
I
SIPAAG
H
MIS
Y
YA
L
GV
V
VGAP
IIA
L
FS
S
RYS
LK
HI
L
L
FL
V
AL
C
VI
GN
AMF
T
LS
S
SY
LM
L
A
I
G
R
L
VSG
F
P
HGAFFG
V
GA
I
V
L
SK
I
I
K
P
GK
V
T
A
AVA
G
M
VS
G
M
T
V
AN
L
LG
I
PLGT
Y
L
S
Q
E
F
S
WR
Y
TFL
L
IA
VFN
I
A
V
M
A
S
V
YFW
V
P
DIRD
EA
K
G
K
L
-
R
EQFHF
LR
S
PA
PW
L
I
F
A
A
T
M
F
G
NA
G
V
F
A
W
F
SY
V
K
P
Y
M
M
F
I
S
G
F
S
ET
A
M
T
F
I
M
M
L
V
G
L
G
MV
L
GN
M
L
S
G
R
I
SG
RY
SPLRIA
A
VTD
F
II
VL
AL
LML
F
--
F
C
G
GM
K
TTSL
I
F
---
AFI
CC
A
G
L
FA
L
SA
PLQ
I
L
L
L
QN
A
KG
G
EL
L
GA
A
GGQ
I
AFNLG
S
A
V
GA
YC
GG
M
M
L
T
-
LGL
A
Y
N
Y
V
ALP
A
A
L
LS
FAA
M
S
-
SLL
L
Y
G
R
YKR
Q
fig|478005.5.peg.2333
Escherichia coli O157:H7 str. EC4486 (33-409/422)
IL
S
LALG
T
FG
L
G
MA
EF
G
I
MG
V
L
TE
L
A
HN
V
G
I
SIPAAG
H
MIS
Y
YA
L
GV
V
VGAP
IIA
L
FS
S
RYS
LK
HI
L
L
FL
V
AL
C
VI
GN
AMF
T
LS
S
SY
LM
L
A
I
G
R
L
VSG
F
P
HGAFFG
V
GA
I
V
L
SK
I
I
K
P
GK
V
T
A
AVA
G
M
VS
G
M
T
V
AN
L
LG
I
PLGT
Y
L
S
Q
E
F
S
WR
Y
TFL
L
IA
VFN
I
A
V
M
A
S
V
YFW
V
P
DIRD
EA
K
G
K
L
-
R
EQFHF
LR
S
PA
PW
L
I
F
A
A
T
M
F
G
NA
G
V
F
A
W
F
SY
V
K
P
Y
M
M
F
I
S
G
F
S
ET
A
M
T
F
I
M
M
L
V
G
L
G
MV
L
GN
M
L
S
G
R
I
SG
RY
SPLRIA
A
VTD
F
II
VL
AL
LML
F
--
F
C
G
GM
K
TTSL
I
F
---
AFI
CC
A
G
L
FA
L
SA
PLQ
I
L
L
L
QN
A
KG
G
EL
L
GA
A
GGQ
I
AFNLG
S
A
V
GA
YC
GG
M
M
L
T
-
LGL
A
Y
N
Y
V
ALP
A
A
L
LS
FAA
M
S
-
SLL
L
Y
G
R
YKR
Q
fig|478006.5.peg.2082
Escherichia coli O157:H7 str. EC4501 (33-409/422)
IL
S
LALG
T
FG
L
G
MA
EF
G
I
MG
V
L
TE
L
A
HN
V
G
I
SIPAAG
H
MIS
Y
YA
L
GV
V
VGAP
IIA
L
FS
S
RYS
LK
HI
L
L
FL
V
AL
C
VI
GN
AMF
T
LS
S
SY
LM
L
A
I
G
R
L
VSG
F
P
HGAFFG
V
GA
I
V
L
SK
I
I
K
P
GK
V
T
A
AVA
G
M
VS
G
M
T
V
AN
L
LG
I
PLGT
Y
L
S
Q
E
F
S
WR
Y
TFL
L
IA
VFN
I
A
V
M
A
S
V
YFW
V
P
DIRD
EA
K
G
K
L
-
R
EQFHF
LR
S
PA
PW
L
I
F
A
A
T
M
F
G
NA
G
V
F
A
W
F
SY
V
K
P
Y
M
M
F
I
S
G
F
S
ET
A
M
T
F
I
M
M
L
V
G
L
G
MV
L
GN
M
L
S
G
R
I
SG
RY
SPLRIA
A
VTD
F
II
VL
AL
LML
F
--
F
C
G
GM
K
TTSL
I
F
---
AFI
CC
A
G
L
FA
L
SA
PLQ
I
L
L
L
QN
A
KG
G
EL
L
GA
A
GGQ
I
AFNLG
S
A
V
GA
YC
GG
M
M
L
T
-
LGL
A
Y
N
Y
V
ALP
A
A
L
LS
FAA
M
S
-
SLL
L
Y
G
R
YKR
Q
fig|478007.5.peg.2963
Escherichia coli O157:H7 str. EC508 (33-409/422)
IL
S
LALG
T
FG
L
G
MA
EF
G
I
MG
V
L
TE
L
A
HN
V
G
I
SIPAAG
H
MIS
Y
YA
L
GV
V
VGAP
IIA
L
FS
S
RYS
LK
HI
L
L
FL
V
AL
C
VI
GN
AMF
T
LS
S
SY
LM
L
A
I
G
R
L
VSG
F
P
HGAFFG
V
GA
I
V
L
SK
I
I
K
P
GK
V
T
A
AVA
G
M
VS
G
M
T
V
AN
L
LG
I
PLGT
Y
L
S
Q
E
F
S
WR
Y
TFL
L
IA
VFN
I
A
V
M
A
S
V
YFW
V
P
DIRD
EA
K
G
K
L
-
R
EQFHF
LR
S
PA
PW
L
I
F
A
A
T
M
F
G
NA
G
V
F
A
W
F
SY
V
K
P
Y
M
M
F
I
S
G
F
S
ET
A
M
T
F
I
M
M
L
V
G
L
G
MV
L
GN
M
L
S
G
R
I
SG
RY
SPLRIA
A
VTD
F
II
VL
AL
LML
F
--
F
C
G
GM
K
TTSL
I
F
---
AFI
CC
A
G
L
FA
L
SA
PLQ
I
L
L
L
QN
A
KG
G
EL
L
GA
A
GGQ
I
AFNLG
S
A
V
GA
YC
GG
M
M
L
T
-
LGL
A
Y
N
Y
V
ALP
A
A
L
LS
FAA
M
S
-
SLL
L
Y
G
R
YKR
Q
fig|478008.5.peg.1531
Escherichia coli O157:H7 str. EC869 (33-409/422)
IL
S
LALG
T
FG
L
G
MA
EF
G
I
MG
V
L
TE
L
A
HN
V
G
I
SIPAAG
H
MIS
Y
YA
L
GV
V
VGAP
IIA
L
FS
S
RYS
LK
HI
L
L
FL
V
AL
C
VI
GN
AMF
T
LS
S
SY
LM
L
A
I
G
R
L
VSG
F
P
HGAFFG
V
GA
I
V
L
SK
I
I
K
P
GK
V
T
A
AVA
G
M
VS
G
M
T
V
AN
L
LG
I
PLGT
Y
L
S
Q
E
F
S
WR
Y
TFL
L
IA
VFN
I
A
V
M
A
S
V
YFW
V
P
DIRD
EA
K
G
K
L
-
R
EQFHF
LR
S
PA
PW
L
I
F
A
A
T
M
F
G
NA
G
V
F
A
W
F
SY
V
K
P
Y
M
M
F
I
S
G
F
S
ET
A
M
T
F
I
M
M
L
V
G
L
G
MV
L
GN
M
L
S
G
R
I
SG
RY
SPLRIA
A
VTD
F
II
VL
AL
LML
F
--
F
C
G
GM
K
TTSL
I
F
---
AFI
CC
A
G
L
FA
L
SA
PLQ
I
L
L
L
QN
A
KG
G
EL
L
GA
A
GGQ
I
AFNLG
S
A
V
GA
YC
GG
M
M
L
T
-
LGL
A
Y
N
Y
V
ALP
A
A
L
LS
FAA
M
S
-
SLL
L
Y
G
R
YKR
Q
fig|637388.3.peg.927
Escherichia coli O157:H7 str. FRIK2000 (33-409/422)
IL
S
LALG
T
FG
L
G
MA
EF
G
I
MG
V
L
TE
L
A
HN
V
G
I
SIPAAG
H
MIS
Y
YA
L
GV
V
VGAP
IIA
L
FS
S
RYS
LK
HI
L
L
FL
V
AL
C
VI
GN
AMF
T
LS
S
SY
LM
L
A
I
G
R
L
VSG
F
P
HGAFFG
V
GA
I
V
L
SK
I
I
K
P
GK
V
T
A
AVA
G
M
VS
G
M
T
V
AN
L
LG
I
PLGT
Y
L
S
Q
E
F
S
WR
Y
TFL
L
IA
VFN
I
A
V
M
A
S
V
YFW
V
P
DIRD
EA
K
G
K
L
-
R
EQFHF
LR
S
PA
PW
L
I
F
A
A
T
M
F
G
NA
G
V
F
A
W
F
SY
V
K
P
Y
M
M
F
I
S
G
F
S
ET
A
M
T
F
I
M
M
L
V
G
L
G
MV
L
GN
M
L
S
G
R
I
SG
RY
SPLRIA
A
VTD
F
II
VL
AL
LML
F
--
F
C
G
GM
K
TTSL
I
F
---
AFI
CC
A
G
L
FA
L
SA
PLQ
I
L
L
L
QN
A
KG
G
EL
L
GA
A
GGQ
I
AFNLG
S
A
V
GA
YC
GG
M
M
L
T
-
LGL
A
Y
N
Y
V
ALP
A
A
L
LS
FAA
M
S
-
SLL
L
Y
G
R
YKR
Q
fig|570506.3.peg.2282
Escherichia coli O157:H7 str. FRIK966 (33-409/422)
IL
S
LALG
T
FG
L
G
MA
EF
G
I
MG
V
L
TE
L
A
HN
V
G
I
SIPAAG
H
MIS
Y
YA
L
GV
V
VGAP
IIA
L
FS
S
RYS
LK
HI
L
L
FL
V
AL
C
VI
GN
AMF
T
LS
S
SY
LM
L
A
I
G
R
L
VSG
F
P
HGAFFG
V
GA
I
V
L
SK
I
I
K
P
GK
V
T
A
AVA
G
M
VS
G
M
T
V
AN
L
LG
I
PLGT
Y
L
S
Q
E
F
S
WR
Y
TFL
L
IA
VFN
I
A
V
M
A
S
V
YFW
V
P
DIRD
EA
K
G
K
L
-
R
EQFHF
LR
S
PA
PW
L
I
F
A
A
T
M
F
G
NA
G
V
F
A
W
F
SY
V
K
P
Y
M
M
F
I
S
G
F
S
ET
A
M
T
F
I
M
M
L
V
G
L
G
MV
L
GN
M
L
S
G
R
I
SG
RY
SPLRIA
A
VTD
F
II
VL
AL
LML
F
--
F
C
G
GM
K
TTSL
I
F
---
AFI
CC
A
G
L
FA
L
SA
PLQ
I
L
L
L
QN
A
KG
G
EL
L
GA
A
GGQ
I
AFNLG
S
A
V
GA
YC
GG
M
M
L
T
-
LGL
A
Y
N
Y
V
ALP
A
A
L
LS
FAA
M
S
-
SLL
L
Y
G
R
YKR
Q
fig|386585.9.peg.543
Escherichia coli O157:H7 str. Sakai (33-409/422)
IL
S
LALG
T
FG
L
G
MA
EF
G
I
MG
V
L
TE
L
A
HN
V
G
I
SIPAAG
H
MIS
Y
YA
L
GV
V
VGAP
IIA
L
FS
S
RYS
LK
HI
L
L
FL
V
AL
C
VI
GN
AMF
T
LS
S
SY
LM
L
A
I
G
R
L
VSG
F
P
HGAFFG
V
GA
I
V
L
SK
I
I
K
P
GK
V
T
A
AVA
G
M
VS
G
M
T
V
AN
L
LG
I
PLGT
Y
L
S
Q
E
F
S
WR
Y
TFL
L
IA
VFN
I
A
V
M
A
S
V
YFW
V
P
DIRD
EA
K
G
K
L
-
R
EQFHF
LR
S
PA
PW
L
I
F
A
A
T
M
F
G
NA
G
V
F
A
W
F
SY
V
K
P
Y
M
M
F
I
S
G
F
S
ET
A
M
T
F
I
M
M
L
V
G
L
G
MV
L
GN
M
L
S
G
R
I
SG
RY
SPLRIA
A
VTD
F
II
VL
AL
LML
F
--
F
C
G
GM
K
TTSL
I
F
---
AFI
CC
A
G
L
FA
L
SA
PLQ
I
L
L
L
QN
A
KG
G
EL
L
GA
A
GGQ
I
AFNLG
S
A
V
GA
YC
GG
M
M
L
T
-
LGL
A
Y
N
Y
V
ALP
A
A
L
LS
FAA
M
S
-
SLL
L
Y
G
R
YKR
Q
fig|544404.4.peg.456
Escherichia coli O157:H7 str. TW14359 (33-409/422)
IL
S
LALG
T
FG
L
G
MA
EF
G
I
MG
V
L
TE
L
A
HN
V
G
I
SIPAAG
H
MIS
Y
YA
L
GV
V
VGAP
IIA
L
FS
S
RYS
LK
HI
L
L
FL
V
AL
C
VI
GN
AMF
T
LS
S
SY
LM
L
A
I
G
R
L
VSG
F
P
HGAFFG
V
GA
I
V
L
SK
I
I
K
P
GK
V
T
A
AVA
G
M
VS
G
M
T
V
AN
L
LG
I
PLGT
Y
L
S
Q
E
F
S
WR
Y
TFL
L
IA
VFN
I
A
V
M
A
S
V
YFW
V
P
DIRD
EA
K
G
K
L
-
R
EQFHF
LR
S
PA
PW
L
I
F
A
A
T
M
F
G
NA
G
V
F
A
W
F
SY
V
K
P
Y
M
M
F
I
S
G
F
S
ET
A
M
T
F
I
M
M
L
V
G
L
G
MV
L
GN
M
L
S
G
R
I
SG
RY
SPLRIA
A
VTD
F
II
VL
AL
LML
F
--
F
C
G
GM
K
TTSL
I
F
---
AFI
CC
A
G
L
FA
L
SA
PLQ
I
L
L
L
QN
A
KG
G
EL
L
GA
A
GGQ
I
AFNLG
S
A
V
GA
YC
GG
M
M
L
T
-
LGL
A
Y
N
Y
V
ALP
A
A
L
LS
FAA
M
S
-
SLL
L
Y
G
R
YKR
Q
fig|502346.5.peg.769
Escherichia coli O157:H7 str. TW14588 (33-409/422)
IL
S
LALG
T
FG
L
G
MA
EF
G
I
MG
V
L
TE
L
A
HN
V
G
I
SIPAAG
H
MIS
Y
YA
L
GV
V
VGAP
IIA
L
FS
S
RYS
LK
HI
L
L
FL
V
AL
C
VI
GN
AMF
T
LS
S
SY
LM
L
A
I
G
R
L
VSG
F
P
HGAFFG
V
GA
I
V
L
SK
I
I
K
P
GK
V
T
A
AVA
G
M
VS
G
M
T
V
AN
L
LG
I
PLGT
Y
L
S
Q
E
F
S
WR
Y
TFL
L
IA
VFN
I
A
V
M
A
S
V
YFW
V
P
DIRD
EA
K
G
K
L
-
R
EQFHF
LR
S
PA
PW
L
I
F
A
A
T
M
F
G
NA
G
V
F
A
W
F
SY
V
K
P
Y
M
M
F
I
S
G
F
S
ET
A
M
T
F
I
M
M
L
V
G
L
G
MV
L
GN
M
L
S
G
R
I
SG
RY
SPLRIA
A
VTD
F
II
VL
AL
LML
F
--
F
C
G
GM
K
TTSL
I
F
---
AFI
CC
A
G
L
FA
L
SA
PLQ
I
L
L
L
QN
A
KG
G
EL
L
GA
A
GGQ
I
AFNLG
S
A
V
GA
YC
GG
M
M
L
T
-
LGL
A
Y
N
Y
V
ALP
A
A
L
LS
FAA
M
S
-
SLL
L
Y
G
R
YKR
Q
fig|573235.3.peg.429
Escherichia coli O26:H11 str. 11368 (33-409/422)
IL
S
LALG
T
FG
L
G
MA
EF
G
I
MG
V
L
TE
L
A
HN
V
G
I
SIPAAG
H
MIS
Y
YA
L
GV
V
VGAP
IIA
L
FS
S
RYS
LK
HI
L
L
FL
V
AL
C
VI
GN
AMF
T
LS
S
SY
LM
L
A
I
G
R
L
VSG
F
P
HGAFFG
V
GA
I
V
L
SK
I
I
K
P
GK
V
T
A
AVA
G
M
VS
G
M
T
V
AN
L
LG
I
PLGT
Y
L
S
Q
E
F
S
WR
Y
TFL
L
IA
VFN
I
A
V
M
A
S
V
YFW
V
P
DIRD
EA
K
G
K
L
-
R
EQFHF
LR
S
PA
PW
L
I
F
A
A
T
M
F
G
NA
G
V
F
A
W
F
SY
V
K
P
Y
M
M
F
I
S
G
F
S
ET
A
M
T
F
I
M
M
L
V
G
L
G
MV
L
GN
M
L
S
G
R
I
SG
RY
SPLRIA
A
VTD
F
II
VL
AL
LML
F
--
F
C
C
GM
K
TTSL
I
F
---
AFI
CC
A
G
L
FA
L
SA
PLQ
I
L
L
L
QN
A
KG
G
EL
L
GA
A
GGQ
I
AFNLG
S
A
V
GA
YC
GG
M
M
L
T
-
LGL
A
Y
N
Y
V
ALP
A
A
L
LS
FAA
M
S
-
SLL
L
Y
G
R
YKR
Q
fig|701177.3.peg.495
Escherichia coli O55:H7 str. CB9615 (33-409/422)
IL
S
LALG
T
FG
L
G
MA
EF
G
I
MG
V
L
TE
L
A
HN
V
G
I
SIPAAG
H
MIS
Y
YA
L
GV
V
VGAP
IIA
L
FS
S
RYS
LK
HI
L
L
FL
V
AL
C
VI
GN
AMF
T
LS
S
SY
LM
L
A
I
G
R
L
VSG
F
P
HGAFFG
V
GA
I
V
L
SK
I
I
K
P
GK
V
T
A
AVA
G
M
VS
G
M
T
V
AN
L
LG
I
PLGT
Y
L
S
Q
E
F
S
WR
Y
TFL
L
IA
VFN
I
A
V
M
A
S
V
YFW
V
P
DIRD
EA
K
G
K
L
-
R
EQFHF
LR
S
PA
PW
L
I
F
A
A
T
M
F
G
NA
G
V
F
A
W
F
SY
V
K
P
Y
M
M
F
I
S
G
F
S
ET
A
M
T
F
I
M
M
L
V
G
L
G
MV
L
GN
M
L
S
G
R
I
SG
RY
SPLRIA
A
VTD
F
II
VL
AL
LML
F
--
F
C
G
GM
K
TTSL
I
F
---
AFI
CC
A
G
L
FA
L
SA
PLQ
I
L
L
L
QN
A
KG
G
EL
L
GA
A
GGQ
I
AFNLG
S
A
V
GA
YC
GG
M
M
L
T
-
LGL
A
Y
N
Y
V
ALP
A
A
L
LS
FAA
M
S
-
SLL
L
Y
G
R
YKR
Q
fig|409438.11.peg.540
Escherichia coli SE11 (33-409/422)
IL
S
LALG
T
FG
L
G
MA
EF
G
I
MG
V
L
TE
L
A
HN
V
G
I
SIPAAG
H
MIS
Y
YA
L
GV
V
VGAP
IIA
L
FS
S
RYS
LK
HI
L
L
FL
V
AL
C
VI
GN
AMF
T
LS
S
SY
LM
L
A
I
G
R
L
VSG
F
P
HGAFFG
V
GA
I
V
L
SK
I
I
K
P
GK
V
T
A
AVA
G
M
VS
G
M
T
V
AN
L
LG
I
PLGT
Y
L
S
Q
E
F
S
WR
Y
TFL
L
IA
VFN
I
A
V
M
A
S
V
YFW
V
P
DIRD
EA
K
G
K
L
-
R
EQFHF
LR
S
PA
PW
L
I
F
A
A
T
M
F
G
NA
G
V
F
A
W
F
SY
V
K
P
Y
M
M
F
I
S
G
F
S
ET
A
M
T
F
I
M
M
L
V
G
L
G
MV
L
GN
M
L
S
G
R
I
SG
RY
SPLRIA
A
VTD
F
II
VL
AL
LML
F
--
F
C
G
GM
K
TTSL
I
F
---
AFI
CC
A
G
L
FA
L
SA
PLQ
I
L
L
L
QN
A
KG
G
EL
L
GA
A
GGQ
I
AFNLG
S
A
V
GA
YC
GG
M
M
L
T
-
LGL
A
Y
N
Y
V
ALP
A
A
L
LS
FAA
M
S
-
SLL
L
Y
G
R
YKR
Q
fig|344601.5.peg.3284
Escherichia coli B171 (33-409/422)
IL
S
LALG
T
FG
L
G
MA
EF
G
I
MG
V
L
TE
L
A
HN
V
G
I
SIPAAG
H
MIS
Y
YA
L
GV
V
VGAP
IIA
L
FS
S
RYS
LK
HI
L
L
FL
V
AL
C
VI
GN
AMF
T
LS
S
SY
LM
L
A
I
G
R
L
VSG
F
P
HGAFFG
V
GA
I
V
L
SK
I
I
K
P
GK
V
T
A
AVA
G
M
VS
G
M
T
V
AN
L
LG
I
PLGT
Y
L
S
Q
E
F
S
WR
Y
TFL
L
IA
VFN
I
A
V
M
A
S
V
YFW
V
P
DIRD
EA
K
G
K
L
-
R
EQFHF
LR
S
PA
PW
L
I
F
A
A
T
M
F
G
NA
G
V
F
A
W
F
SY
V
K
P
Y
M
M
F
I
S
G
F
S
ET
A
M
T
F
I
M
M
L
V
G
L
G
MV
L
GN
V
L
S
G
R
I
SG
RY
SPLRIA
A
VTD
F
II
VL
AL
LML
F
--
F
C
G
GM
K
TTSL
I
F
---
AFI
CC
A
G
L
FA
L
SA
PLQ
I
L
L
L
QN
A
KG
G
EL
L
GA
A
GGQ
I
AFNLG
S
A
V
GA
YC
GG
M
M
L
T
-
LGL
A
Y
N
Y
V
ALP
A
A
L
LS
FAA
M
S
-
SLL
L
Y
G
R
YKR
Q
fig|340185.4.peg.3759
Escherichia coli E22 (33-409/422)
IL
S
LALG
T
FG
L
G
MA
EF
G
I
MG
V
L
TE
L
A
HN
V
G
I
SIPAAG
H
MIS
Y
YA
L
GV
V
VGAP
IIA
L
FS
S
RYS
LK
HI
L
L
FL
V
AL
C
VI
GN
AMF
T
LS
S
SY
LM
L
A
I
G
R
L
VSG
F
P
HGAFFG
V
GA
I
V
L
SK
I
I
K
P
GK
V
T
A
AVA
G
M
VS
G
M
T
V
AN
L
LG
I
PLGT
Y
L
S
Q
E
F
S
WR
Y
TFL
L
IA
VFN
I
A
V
M
A
S
V
YFW
V
P
DIRD
EA
K
G
K
L
-
R
EQFHF
LR
S
PA
PW
L
I
F
A
A
T
M
F
G
NA
G
V
F
A
W
F
SY
V
K
P
Y
M
M
F
I
S
G
F
S
ET
A
M
T
F
I
M
M
L
V
G
L
G
MV
L
GN
V
L
S
G
R
I
SG
RY
SPLRIA
A
VTD
F
II
VL
AL
LML
F
--
F
C
G
GM
K
TTSL
I
F
---
AFI
CC
A
G
L
FA
L
SA
PLQ
I
L
L
L
QN
A
KG
G
EL
L
GA
A
GGQ
I
AFNLG
S
A
V
GA
YC
GG
M
M
L
T
-
LGL
A
Y
N
Y
V
ALP
A
A
L
LS
FAA
M
S
-
SLL
L
Y
G
R
YKR
Q
fig|585395.4.peg.388
Escherichia coli O103:H2 str. 12009 (33-409/422)
IL
S
LALG
T
FG
L
G
MA
EF
G
I
MG
V
L
TE
L
A
HN
V
G
I
SIPAAG
H
MIS
Y
YA
L
GV
V
VGAP
IIA
L
FS
S
RYS
LK
HI
L
L
FL
V
AL
C
VI
GN
AMF
T
LS
S
SY
LM
L
A
I
G
R
L
VSG
F
P
HGAFFG
V
GA
I
V
L
SK
I
I
K
P
GK
V
T
A
AVA
G
M
VS
G
M
T
V
AN
L
LG
I
PLGT
Y
L
S
Q
E
F
S
WR
Y
TFL
L
IA
VFN
I
A
V
M
A
S
V
YFW
V
P
DIRD
EA
K
G
K
L
-
R
EQFHF
LR
S
PA
PW
L
I
F
A
A
T
M
F
G
NA
G
V
F
A
W
F
SY
V
K
P
Y
M
M
F
I
S
G
F
S
ET
A
M
T
F
I
M
M
L
V
G
L
G
MV
L
GN
V
L
S
G
R
I
SG
RY
SPLRIA
A
VTD
F
II
VL
AL
LML
F
--
F
C
G
GM
K
TTSL
I
F
---
AFI
CC
A
G
L
FA
L
SA
PLQ
I
L
L
L
QN
A
KG
G
EL
L
GA
A
GGQ
I
AFNLG
S
A
V
GA
YC
GG
M
M
L
T
-
LGL
A
Y
N
Y
V
ALP
A
A
L
LS
FAA
M
S
-
SLL
L
Y
G
R
YKR
Q
fig|340184.6.peg.1882
Escherichia coli B7A (33-409/422)
IL
S
LALG
T
FG
L
G
MA
EF
G
I
MG
V
L
TE
L
A
HN
V
G
I
SIPAAG
H
MIS
Y
YA
L
GV
V
VGAP
IIA
L
FS
S
RYS
LK
HI
L
L
FL
V
AL
C
VI
GN
AMF
T
LS
S
SY
LM
L
A
I
G
R
L
VSG
F
P
HGAFFG
V
GA
I
V
L
SK
I
I
K
P
GK
V
T
A
AVA
G
M
VS
G
M
T
V
AN
L
LG
I
PLGT
Y
L
S
Q
E
F
S
WR
Y
TFL
L
IA
VFN
I
A
V
M
A
S
V
YFW
V
P
DIRD
EA
K
G
K
L
-
R
EQFHF
LR
S
PA
PW
L
I
F
A
A
T
M
F
G
NA
G
V
F
A
W
F
SY
V
K
P
Y
M
M
F
I
S
G
F
S
ET
A
M
T
F
I
M
M
L
V
G
L
G
MV
L
GN
M
L
S
G
R
V
SG
RY
SPLRIA
A
VTD
F
II
VL
AL
LML
F
--
F
C
G
GM
K
ITSL
I
F
---
AFI
CC
A
G
L
FA
L
SA
PLQ
I
L
L
L
QN
A
KG
G
EL
L
GA
A
GGQ
I
AFNLG
S
A
V
GA
YC
GG
M
M
L
T
-
LGL
A
Y
N
Y
V
ALP
A
A
L
LS
FAA
M
S
-
SLL
L
Y
G
R
YKR
Q
fig|679204.3.peg.2014
Escherichia coli MS 145-7 (33-409/422)
IL
S
LALG
T
FG
L
G
MA
EF
G
I
MG
V
L
TE
L
A
HN
V
G
I
SIPAAG
H
MIS
Y
YA
L
GV
V
VGAP
IIA
L
FS
S
RYS
LK
HI
L
L
FL
V
AL
C
VI
GN
AMF
T
LS
S
SY
LM
L
A
I
G
R
L
VSG
F
P
HGAFFG
V
GA
I
V
L
SK
I
I
K
P
GK
V
T
A
AVA
G
M
VS
G
M
T
V
AN
L
LG
I
PLGT
Y
L
S
Q
E
F
S
WR
Y
TFL
L
IA
VFN
I
A
V
M
A
S
V
YFW
V
P
DIRD
EA
K
G
K
L
-
R
EQFHF
LR
S
PA
PW
L
I
F
A
A
T
M
F
G
NA
G
V
F
A
W
F
SY
V
K
P
Y
M
M
F
I
S
G
F
S
ET
A
M
T
F
I
M
M
L
V
G
L
G
MV
L
GN
M
L
S
G
R
V
SG
RY
SPLRIA
A
VTD
F
II
VL
AL
LML
F
--
F
C
G
GM
K
ITSL
I
F
---
AFI
CC
A
G
L
FA
L
SA
PLQ
I
L
L
L
QN
A
KG
G
EL
L
GA
A
GGQ
I
AFNLG
S
A
V
GA
YC
GG
M
M
L
T
-
LGL
A
Y
N
Y
V
ALP
A
A
L
LS
FAA
M
S
-
SLL
L
Y
G
R
YKR
Q
fig|585396.4.peg.436
Escherichia coli O111:H- str. 11128 (33-409/422)
IL
S
LALG
T
FG
L
G
MA
EF
G
I
MG
V
L
TE
L
A
HN
V
G
I
SIPAAG
H
MIS
Y
YA
L
GV
V
VGAP
IIA
L
FS
S
RYS
LK
HI
L
L
FL
V
AL
C
VI
GN
AMF
T
LS
S
SY
LM
L
A
I
G
R
L
VSG
F
P
HGAFFG
V
GA
I
V
L
SK
I
I
K
P
GK
V
T
A
AVA
G
M
VS
G
M
T
V
AN
L
LG
I
PLGT
Y
L
S
Q
E
F
S
WR
Y
TFL
L
IA
VFN
I
A
V
M
A
S
V
YFW
V
P
DIRD
EA
K
G
K
L
-
R
EQFHF
LR
S
PA
PW
L
I
F
A
A
T
M
F
G
NA
G
V
F
A
W
F
SY
V
K
P
Y
M
M
F
I
S
G
F
S
ET
A
M
T
F
I
M
M
L
V
G
L
G
MV
L
GN
M
L
S
G
R
I
SG
RY
SPLRIA
A
VTD
F
II
VL
AL
LML
F
--
F
C
G
GM
K
TTSL
I
F
---
AFI
CC
A
E
L
FA
L
SA
PLQ
I
L
L
L
QN
A
KG
G
EL
L
GA
A
GGQ
I
AFNLG
S
A
V
GA
YC
GG
M
M
L
T
-
LGL
A
Y
N
Y
V
ALP
A
A
L
LS
FAA
M
S
-
SLL
L
Y
G
R
YKR
Q
fig|362663.8.peg.450
Escherichia coli 536 (33-409/422)
IL
S
LALG
T
FG
L
G
MA
EF
G
I
MG
V
L
TE
L
A
HN
V
G
I
SIPAAG
H
MIS
Y
YA
L
GV
V
VGAP
IIA
L
FS
S
RYS
LK
HI
L
L
FL
V
AL
C
VI
GN
AMF
T
LS
S
SY
LM
L
A
I
G
R
L
VSG
F
P
HGAFFG
V
GA
I
V
L
SK
I
I
K
P
GK
V
T
A
AVA
G
M
VS
G
M
T
V
AN
L
LG
I
PLGT
Y
L
S
Q
E
F
S
WR
Y
TFL
L
IA
VFN
I
A
V
M
A
S
V
YFW
V
P
DIRD
EA
K
G
K
L
-
R
EQFHF
LR
S
PA
PW
L
I
F
A
A
T
M
F
G
NA
G
V
F
A
W
F
SY
V
K
P
Y
M
M
F
I
S
G
F
S
ET
A
M
T
F
I
M
M
L
V
G
L
G
MV
L
GN
M
L
S
G
R
I
SG
RY
SPLRIA
A
VTD
F
II
VL
AL
LML
F
--
F
F
G
GM
K
TTSL
I
F
---
AFI
CC
A
G
L
FA
L
SA
PLQ
I
L
L
L
QN
A
KG
G
EL
L
GA
A
GGQ
I
AFNLG
S
A
V
GA
YC
GG
M
M
L
T
-
LGL
A
Y
N
Y
V
ALP
A
A
L
LS
FAA
M
S
-
SLL
L
Y
G
R
YKR
Q
fig|362663.9.peg.450
Escherichia coli 536 (33-409/422)
IL
S
LALG
T
FG
L
G
MA
EF
G
I
MG
V
L
TE
L
A
HN
V
G
I
SIPAAG
H
MIS
Y
YA
L
GV
V
VGAP
IIA
L
FS
S
RYS
LK
HI
L
L
FL
V
AL
C
VI
GN
AMF
T
LS
S
SY
LM
L
A
I
G
R
L
VSG
F
P
HGAFFG
V
GA
I
V
L
SK
I
I
K
P
GK
V
T
A
AVA
G
M
VS
G
M
T
V
AN
L
LG
I
PLGT
Y
L
S
Q
E
F
S
WR
Y
TFL
L
IA
VFN
I
A
V
M
A
S
V
YFW
V
P
DIRD
EA
K
G
K
L
-
R
EQFHF
LR
S
PA
PW
L
I
F
A
A
T
M
F
G
NA
G
V
F
A
W
F
SY
V
K
P
Y
M
M
F
I
S
G
F
S
ET
A
M
T
F
I
M
M
L
V
G
L
G
MV
L
GN
M
L
S
G
R
I
SG
RY
SPLRIA
A
VTD
F
II
VL
AL
LML
F
--
F
F
G
GM
K
TTSL
I
F
---
AFI
CC
A
G
L
FA
L
SA
PLQ
I
L
L
L
QN
A
KG
G
EL
L
GA
A
GGQ
I
AFNLG
S
A
V
GA
YC
GG
M
M
L
T
-
LGL
A
Y
N
Y
V
ALP
A
A
L
LS
FAA
M
S
-
SLL
L
Y
G
R
YKR
Q
fig|405955.13.peg.393
Escherichia coli APEC O1 (33-409/422)
IL
S
LALG
T
FG
L
G
MA
EF
G
I
MG
V
L
TE
L
A
HN
V
G
I
SIPAAG
H
MIS
Y
YA
L
GV
V
VGAP
IIA
L
FS
S
RYS
LK
HI
L
L
FL
V
AL
C
VI
GN
AMF
T
LS
S
SY
LM
L
A
I
G
R
L
VSG
F
P
HGAFFG
V
GA
I
V
L
SK
I
I
K
P
GK
V
T
A
AVA
G
M
VS
G
M
T
V
AN
L
LG
I
PLGT
Y
L
S
Q
E
F
S
WR
Y
TFL
L
IA
VFN
I
A
V
M
A
S
V
YFW
V
P
DIRD
EA
K
G
K
L
-
R
EQFHF
LR
S
PA
PW
L
I
F
A
A
T
M
F
G
NA
G
V
F
A
W
F
SY
V
K
P
Y
M
M
F
I
S
G
F
S
ET
A
M
T
F
I
M
M
L
V
G
L
G
MV
L
GN
M
L
S
G
R
I
SG
RY
SPLRIA
A
VTD
F
II
VL
AL
LML
F
--
F
F
G
GM
K
TTSL
I
F
---
AFI
CC
A
G
L
FA
L
SA
PLQ
I
L
L
L
QN
A
KG
G
EL
L
GA
A
GGQ
I
AFNLG
S
A
V
GA
YC
GG
M
M
L
T
-
LGL
A
Y
N
Y
V
ALP
A
A
L
LS
FAA
M
S
-
SLL
L
Y
G
R
YKR
Q
fig|405955.9.peg.317
Escherichia coli APEC O1 (33-409/422)
IL
S
LALG
T
FG
L
G
MA
EF
G
I
MG
V
L
TE
L
A
HN
V
G
I
SIPAAG
H
MIS
Y
YA
L
GV
V
VGAP
IIA
L
FS
S
RYS
LK
HI
L
L
FL
V
AL
C
VI
GN
AMF
T
LS
S
SY
LM
L
A
I
G
R
L
VSG
F
P
HGAFFG
V
GA
I
V
L
SK
I
I
K
P
GK
V
T
A
AVA
G
M
VS
G
M
T
V
AN
L
LG
I
PLGT
Y
L
S
Q
E
F
S
WR
Y
TFL
L
IA
VFN
I
A
V
M
A
S
V
YFW
V
P
DIRD
EA
K
G
K
L
-
R
EQFHF
LR
S
PA
PW
L
I
F
A
A
T
M
F
G
NA
G
V
F
A
W
F
SY
V
K
P
Y
M
M
F
I
S
G
F
S
ET
A
M
T
F
I
M
M
L
V
G
L
G
MV
L
GN
M
L
S
G
R
I
SG
RY
SPLRIA
A
VTD
F
II
VL
AL
LML
F
--
F
F
G
GM
K
TTSL
I
F
---
AFI
CC
A
G
L
FA
L
SA
PLQ
I
L
L
L
QN
A
KG
G
EL
L
GA
A
GGQ
I
AFNLG
S
A
V
GA
YC
GG
M
M
L
T
-
LGL
A
Y
N
Y
V
ALP
A
A
L
LS
FAA
M
S
-
SLL
L
Y
G
R
YKR
Q
fig|585397.7.peg.415
Escherichia coli ED1a (33-409/422)
IL
S
LALG
T
FG
L
G
MA
EF
G
I
MG
V
L
TE
L
A
HN
V
G
I
SIPAAG
H
MIS
Y
YA
L
GV
V
VGAP
IIA
L
FS
S
RYS
LK
HI
L
L
FL
V
AL
C
VI
GN
AMF
T
LS
S
SY
LM
L
A
I
G
R
L
VSG
F
P
HGAFFG
V
GA
I
V
L
SK
I
I
K
P
GK
V
T
A
AVA
G
M
VS
G
M
T
V
AN
L
LG
I
PLGT
Y
L
S
Q
E
F
S
WR
Y
TFL
L
IA
VFN
I
A
V
M
A
S
V
YFW
V
P
DIRD
EA
K
G
K
L
-
R
EQFHF
LR
S
PA
PW
L
I
F
A
A
T
M
F
G
NA
G
V
F
A
W
F
SY
V
K
P
Y
M
M
F
I
S
G
F
S
ET
A
M
T
F
I
M
M
L
V
G
L
G
MV
L
GN
M
L
S
G
R
I
SG
RY
SPLRIA
A
VTD
F
II
VL
AL
LML
F
--
F
F
G
GM
K
TTSL
I
F
---
AFI
CC
A
G
L
FA
L
SA
PLQ
I
L
L
L
QN
A
KG
G
EL
L
GA
A
GGQ
I
AFNLG
S
A
V
GA
YC
GG
M
M
L
T
-
LGL
A
Y
N
Y
V
ALP
A
A
L
LS
FAA
M
S
-
SLL
L
Y
G
R
YKR
Q
fig|585397.9.peg.417
Escherichia coli ED1a (33-409/422)
IL
S
LALG
T
FG
L
G
MA
EF
G
I
MG
V
L
TE
L
A
HN
V
G
I
SIPAAG
H
MIS
Y
YA
L
GV
V
VGAP
IIA
L
FS
S
RYS
LK
HI
L
L
FL
V
AL
C
VI
GN
AMF
T
LS
S
SY
LM
L
A
I
G
R
L
VSG
F
P
HGAFFG
V
GA
I
V
L
SK
I
I
K
P
GK
V
T
A
AVA
G
M
VS
G
M
T
V
AN
L
LG
I
PLGT
Y
L
S
Q
E
F
S
WR
Y
TFL
L
IA
VFN
I
A
V
M
A
S
V
YFW
V
P
DIRD
EA
K
G
K
L
-
R
EQFHF
LR
S
PA
PW
L
I
F
A
A
T
M
F
G
NA
G
V
F
A
W
F
SY
V
K
P
Y
M
M
F
I
S
G
F
S
ET
A
M
T
F
I
M
M
L
V
G
L
G
MV
L
GN
M
L
S
G
R
I
SG
RY
SPLRIA
A
VTD
F
II
VL
AL
LML
F
--
F
F
G
GM
K
TTSL
I
F
---
AFI
CC
A
G
L
FA
L
SA
PLQ
I
L
L
L
QN
A
KG
G
EL
L
GA
A
GGQ
I
AFNLG
S
A
V
GA
YC
GG
M
M
L
T
-
LGL
A
Y
N
Y
V
ALP
A
A
L
LS
FAA
M
S
-
SLL
L
Y
G
R
YKR
Q
fig|340197.5.peg.3785
Escherichia coli F11 (33-409/422)
IL
S
LALG
T
FG
L
G
MA
EF
G
I
MG
V
L
TE
L
A
HN
V
G
I
SIPAAG
H
MIS
Y
YA
L
GV
V
VGAP
IIA
L
FS
S
RYS
LK
HI
L
L
FL
V
AL
C
VI
GN
AMF
T
LS
S
SY
LM
L
A
I
G
R
L
VSG
F
P
HGAFFG
V
GA
I
V
L
SK
I
I
K
P
GK
V
T
A
AVA
G
M
VS
G
M
T
V
AN
L
LG
I
PLGT
Y
L
S
Q
E
F
S
WR
Y
TFL
L
IA
VFN
I
A
V
M
A
S
V
YFW
V
P
DIRD
EA
K
G
K
L
-
R
EQFHF
LR
S
PA
PW
L
I
F
A
A
T
M
F
G
NA
G
V
F
A
W
F
SY
V
K
P
Y
M
M
F
I
S
G
F
S
ET
A
M
T
F
I
M
M
L
V
G
L
G
MV
L
GN
M
L
S
G
R
I
SG
RY
SPLRIA
A
VTD
F
II
VL
AL
LML
F
--
F
F
G
GM
K
TTSL
I
F
---
AFI
CC
A
G
L
FA
L
SA
PLQ
I
L
L
L
QN
A
KG
G
EL
L
GA
A
GGQ
I
AFNLG
S
A
V
GA
YC
GG
M
M
L
T
-
LGL
A
Y
N
Y
V
ALP
A
A
L
LS
FAA
M
S
-
SLL
L
Y
G
R
YKR
Q
fig|714962.3.peg.383
Escherichia coli IHE3034 (33-409/422)
IL
S
LALG
T
FG
L
G
MA
EF
G
I
MG
V
L
TE
L
A
HN
V
G
I
SIPAAG
H
MIS
Y
YA
L
GV
V
VGAP
IIA
L
FS
S
RYS
LK
HI
L
L
FL
V
AL
C
VI
GN
AMF
T
LS
S
SY
LM
L
A
I
G
R
L
VSG
F
P
HGAFFG
V
GA
I
V
L
SK
I
I
K
P
GK
V
T
A
AVA
G
M
VS
G
M
T
V
AN
L
LG
I
PLGT
Y
L
S
Q
E
F
S
WR
Y
TFL
L
IA
VFN
I
A
V
M
A
S
V
YFW
V
P
DIRD
EA
K
G
K
L
-
R
EQFHF
LR
S
PA
PW
L
I
F
A
A
T
M
F
G
NA
G
V
F
A
W
F
SY
V
K
P
Y
M
M
F
I
S
G
F
S
ET
A
M
T
F
I
M
M
L
V
G
L
G
MV
L
GN
M
L
S
G
R
I
SG
RY
SPLRIA
A
VTD
F
II
VL
AL
LML
F
--
F
F
G
GM
K
TTSL
I
F
---
AFI
CC
A
G
L
FA
L
SA
PLQ
I
L
L
L
QN
A
KG
G
EL
L
GA
A
GGQ
I
AFNLG
S
A
V
GA
YC
GG
M
M
L
T
-
LGL
A
Y
N
Y
V
ALP
A
A
L
LS
FAA
M
S
-
SLL
L
Y
G
R
YKR
Q
fig|749550.3.peg.4945
Escherichia coli MS 200-1 (33-409/422)
IL
S
LALG
T
FG
L
G
MA
EF
G
I
MG
V
L
TE
L
A
HN
V
G
I
SIPAAG
H
MIS
Y
YA
L
GV
V
VGAP
IIA
L
FS
S
RYS
LK
HI
L
L
FL
V
AL
C
VI
GN
AMF
T
LS
S
SY
LM
L
A
I
G
R
L
VSG
F
P
HGAFFG
V
GA
I
V
L
SK
I
I
K
P
GK
V
T
A
AVA
G
M
VS
G
M
T
V
AN
L
LG
I
PLGT
Y
L
S
Q
E
F
S
WR
Y
TFL
L
IA
VFN
I
A
V
M
A
S
V
YFW
V
P
DIRD
EA
K
G
K
L
-
R
EQFHF
LR
S
PA
PW
L
I
F
A
A
T
M
F
G
NA
G
V
F
A
W
F
SY
V
K
P
Y
M
M
F
I
S
G
F
S
ET
A
M
T
F
I
M
M
L
V
G
L
G
MV
L
GN
M
L
S
G
R
I
SG
RY
SPLRIA
A
VTD
F
II
VL
AL
LML
F
--
F
F
G
GM
K
TTSL
I
F
---
AFI
CC
A
G
L
FA
L
SA
PLQ
I
L
L
L
QN
A
KG
G
EL
L
GA
A
GGQ
I
AFNLG
S
A
V
GA
YC
GG
M
M
L
T
-
LGL
A
Y
N
Y
V
ALP
A
A
L
LS
FAA
M
S
-
SLL
L
Y
G
R
YKR
Q
fig|585035.6.peg.386
Escherichia coli S88 (33-409/422)
IL
S
LALG
T
FG
L
G
MA
EF
G
I
MG
V
L
TE
L
A
HN
V
G
I
SIPAAG
H
MIS
Y
YA
L
GV
V
VGAP
IIA
L
FS
S
RYS
LK
HI
L
L
FL
V
AL
C
VI
GN
AMF
T
LS
S
SY
LM
L
A
I
G
R
L
VSG
F
P
HGAFFG
V
GA
I
V
L
SK
I
I
K
P
GK
V
T
A
AVA
G
M
VS
G
M
T
V
AN
L
LG
I
PLGT
Y
L
S
Q
E
F
S
WR
Y
TFL
L
IA
VFN
I
A
V
M
A
S
V
YFW
V
P
DIRD
EA
K
G
K
L
-
R
EQFHF
LR
S
PA
PW
L
I
F
A
A
T
M
F
G
NA
G
V
F
A
W
F
SY
V
K
P
Y
M
M
F
I
S
G
F
S
ET
A
M
T
F
I
M
M
L
V
G
L
G
MV
L
GN
M
L
S
G
R
I
SG
RY
SPLRIA
A
VTD
F
II
VL
AL
LML
F
--
F
F
G
GM
K
TTSL
I
F
---
AFI
CC
A
G
L
FA
L
SA
PLQ
I
L
L
L
QN
A
KG
G
EL
L
GG
A
GGQ
I
AFNLG
S
A
V
GA
YC
GG
M
M
L
T
-
LGL
A
Y
N
Y
V
ALP
A
A
L
LS
FAA
M
S
-
SLL
L
Y
G
R
YKR
Q
fig|869729.3.peg.3295
Escherichia coli UM146 (33-409/422)
IL
S
LALG
T
FG
L
G
MA
EF
G
I
MG
V
L
TE
L
A
HN
V
G
I
SIPAAG
H
MIS
Y
YA
L
GV
V
VGAP
IIA
L
FS
S
RYS
LK
HI
L
L
FL
V
AL
C
VI
GN
AMF
T
LS
S
SY
LM
L
A
I
G
R
L
VSG
F
P
HGAFFG
V
GA
I
V
L
SK
I
I
K
P
GK
V
T
A
AVA
G
M
VS
G
M
T
V
AN
L
LG
I
PLGT
Y
L
S
Q
E
F
S
WR
Y
TFL
L
IA
VFN
I
A
V
M
A
S
V
YFW
V
P
DIRD
EA
K
G
K
L
-
R
EQFHF
LR
S
PA
PW
L
I
F
A
A
T
M
F
G
NA
G
V
F
A
W
F
SY
V
K
P
Y
M
M
F
I
S
G
F
S
ET
A
M
T
F
I
M
M
L
V
G
L
G
MV
L
GN
M
L
S
G
R
I
SG
RY
SPLRIA
A
VTD
F
II
VL
AL
LML
F
--
F
F
G
GM
K
TTSL
I
F
---
AFI
CC
A
G
L
FA
L
SA
PLQ
I
L
L
L
QN
A
KG
G
EL
L
GA
A
GGQ
I
AFNLG
S
A
V
GA
YC
GG
M
M
L
T
-
LGL
A
Y
N
Y
V
ALP
A
A
L
LS
FAA
M
S
-
SLL
L
Y
G
R
YKR
Q
fig|364106.7.peg.524
Escherichia coli UTI89 (33-409/422)
IL
S
LALG
T
FG
L
G
MA
EF
G
I
MG
V
L
TE
L
A
HN
V
G
I
SIPAAG
H
MIS
Y
YA
L
GV
V
VGAP
IIA
L
FS
S
RYS
LK
HI
L
L
FL
V
AL
C
VI
GN
AMF
T
LS
S
SY
LM
L
A
I
G
R
L
VSG
F
P
HGAFFG
V
GA
I
V
L
SK
I
I
K
P
GK
V
T
A
AVA
G
M
VS
G
M
T
V
AN
L
LG
I
PLGT
Y
L
S
Q
E
F
S
WR
Y
TFL
L
IA
VFN
I
A
V
M
A
S
V
YFW
V
P
DIRD
EA
K
G
K
L
-
R
EQFHF
LR
S
PA
PW
L
I
F
A
A
T
M
F
G
NA
G
V
F
A
W
F
SY
V
K
P
Y
M
M
F
I
S
G
F
S
ET
A
M
T
F
I
M
M
L
V
G
L
G
MV
L
GN
M
L
S
G
R
I
SG
RY
SPLRIA
A
VTD
F
II
VL
AL
LML
F
--
F
F
G
GM
K
TTSL
I
F
---
AFI
CC
A
G
L
FA
L
SA
PLQ
I
L
L
L
QN
A
KG
G
EL
L
GA
A
GGQ
I
AFNLG
S
A
V
GA
YC
GG
M
M
L
T
-
LGL
A
Y
N
Y
V
ALP
A
A
L
LS
FAA
M
S
-
SLL
L
Y
G
R
YKR
Q
fig|364106.8.peg.522
Escherichia coli UTI89 (33-409/422)
IL
S
LALG
T
FG
L
G
MA
EF
G
I
MG
V
L
TE
L
A
HN
V
G
I
SIPAAG
H
MIS
Y
YA
L
GV
V
VGAP
IIA
L
FS
S
RYS
LK
HI
L
L
FL
V
AL
C
VI
GN
AMF
T
LS
S
SY
LM
L
A
I
G
R
L
VSG
F
P
HGAFFG
V
GA
I
V
L
SK
I
I
K
P
GK
V
T
A
AVA
G
M
VS
G
M
T
V
AN
L
LG
I
PLGT
Y
L
S
Q
E
F
S
WR
Y
TFL
L
IA
VFN
I
A
V
M
A
S
V
YFW
V
P
DIRD
EA
K
G
K
L
-
R
EQFHF
LR
S
PA
PW
L
I
F
A
A
T
M
F
G
NA
G
V
F
A
W
F
SY
V
K
P
Y
M
M
F
I
S
G
F
S
ET
A
M
T
F
I
M
M
L
V
G
L
G
MV
L
GN
M
L
S
G
R
I
SG
RY
SPLRIA
A
VTD
F
II
VL
AL
LML
F
--
F
F
G
GM
K
TTSL
I
F
---
AFI
CC
A
G
L
FA
L
SA
PLQ
I
L
L
L
QN
A
KG
G
EL
L
GA
A
GGQ
I
AFNLG
S
A
V
GA
YC
GG
M
M
L
T
-
LGL
A
Y
N
Y
V
ALP
A
A
L
LS
FAA
M
S
-
SLL
L
Y
G
R
YKR
Q
fig|344610.3.peg.3628
Escherichia coli 53638 (5-381/394)
IL
S
LALG
T
FG
L
G
MA
EF
G
I
MG
V
L
TE
L
A
HN
V
G
I
SIPAAG
H
MIS
Y
YA
L
GV
V
VGAP
IIA
L
FS
S
RYS
LK
HI
L
L
FL
V
AL
C
VI
GN
AMF
T
LS
S
SY
LM
L
A
I
G
R
L
VSG
F
P
HGAFFG
V
GA
I
V
L
SK
I
I
K
P
GK
V
T
A
AVA
G
M
VS
G
M
T
V
AN
L
LG
I
PLGT
Y
L
S
Q
E
F
S
WR
Y
TFL
L
IA
VFN
I
A
V
M
A
S
V
YFW
V
P
DIRD
EA
K
G
N
L
-
R
EQFHF
LR
S
PA
PW
L
I
F
A
A
T
M
F
G
NA
G
V
F
A
W
F
SY
V
K
P
Y
M
M
F
I
S
G
F
S
ET
A
M
T
F
I
M
M
L
V
G
L
G
MV
L
GN
M
L
S
G
R
I
SG
RY
SPLRIA
A
VTD
F
II
VL
AL
LML
F
--
F
C
G
GM
K
TTSL
I
F
---
AFI
CC
A
G
L
FA
L
SA
PLQ
I
L
L
L
QN
A
KG
G
EL
L
GA
A
GGQ
I
AFNLG
S
A
V
GA
YC
GG
M
M
L
T
-
LGL
A
Y
N
Y
V
ALP
A
A
L
LS
FAA
M
S
-
SLL
L
Y
G
R
YKR
Q
fig|562.376.peg.238
Escherichia coli WV_060327 (33-409/422)
IL
S
LALG
T
FG
L
G
MA
EF
G
I
MG
V
L
TE
L
A
HN
V
G
I
SIPAAG
H
MIS
Y
YA
L
GV
V
VGAP
IIA
L
FS
S
RYS
LK
HI
L
L
FL
V
AL
C
VI
GN
AMF
T
LS
S
SY
LM
L
A
I
G
R
L
VSG
F
P
HGAFFG
V
GA
I
V
L
SK
I
I
K
P
GK
V
T
A
AVA
G
M
VS
G
M
T
V
AN
L
LG
I
PLGT
Y
L
S
Q
E
F
S
WR
Y
TFL
L
IA
VFN
I
A
V
M
A
S
V
YFW
V
P
DIRD
EA
K
G
K
L
-
R
EQFHF
LR
S
PA
PW
L
I
F
A
A
T
M
F
G
NA
G
V
F
A
W
F
SY
V
K
P
Y
M
M
F
I
S
G
F
S
ET
A
M
T
F
I
M
M
L
V
G
L
G
MV
L
GN
M
L
S
G
R
I
SG
RY
SPLRIA
A
VTD
F
II
VL
AL
LML
F
--
F
F
G
GM
K
TTSL
I
F
---
AFI
CC
A
G
L
FA
L
SA
PLQ
I
L
L
L
QN
A
KG
G
EL
L
GA
A
GGQ
I
AFNLG
S
A
V
GA
YC
GG
M
M
L
T
-
LGL
A
Y
N
Y
V
ALP
A
A
L
LS
FAA
M
S
-
SLL
L
Y
G
R
YKR
Q
fig|656444.3.peg.862
Escherichia coli TA280 (33-409/422)
IL
S
LALG
T
FG
L
G
MA
EF
G
I
MG
V
L
TE
L
A
HN
V
G
I
SIPAAG
H
MIS
Y
YA
L
GV
V
VGAP
IIA
L
FS
S
RYS
LK
HI
L
L
FL
V
AL
C
VI
GN
AMF
T
LS
S
SY
LM
L
A
I
G
R
L
VSG
F
P
HGAFFG
V
GA
I
V
L
SK
I
I
K
P
GK
V
T
A
AVA
G
M
VS
G
M
T
V
AN
L
LG
I
PLGT
Y
L
S
Q
E
F
S
WR
Y
TFL
L
IA
VFN
I
A
V
M
A
S
V
YFW
V
P
DIRD
EA
K
G
K
L
-
R
EQFHF
LR
C
PA
PW
L
I
F
A
A
T
M
F
G
NA
G
V
F
A
W
F
SY
V
K
P
Y
M
M
F
I
S
G
F
S
ET
A
M
T
F
I
M
M
L
V
G
L
G
MV
L
GN
V
L
S
G
R
I
SG
RY
SPLRIA
A
VTD
F
II
VL
AL
LML
F
--
F
F
G
GM
K
TTSL
I
F
---
AFI
CC
A
G
L
FA
L
SA
PLQ
I
L
L
L
QN
A
KG
G
EL
L
GA
A
GGQ
I
AFNLG
S
A
V
GA
YC
GG
M
M
L
T
-
LGL
A
Y
N
Y
V
ALP
A
A
L
LS
FAA
M
S
-
SLL
L
Y
G
R
YKR
Q
fig|550677.3.peg.824
Escherichia coli B354 (33-409/422)
IL
S
LALG
T
FG
L
G
MA
EF
G
I
MG
V
L
TE
L
A
HN
V
G
I
SIPAAG
H
MIS
Y
YA
L
GV
V
VGAP
IIA
L
FS
S
RYS
LK
HI
L
L
FL
V
AL
C
VI
GN
AMF
T
LS
S
SY
LM
L
A
I
G
R
L
VSG
F
P
HGAFFG
V
GA
I
V
L
SK
I
I
K
P
GK
V
T
A
AVA
G
M
VS
G
M
T
V
AN
L
LG
I
PLGT
Y
L
S
Q
E
F
S
WR
Y
TFL
L
IA
VFN
I
A
V
M
A
S
V
YFW
V
P
DIRD
EA
K
G
K
L
-
R
EQFHF
LR
S
PA
PW
L
I
F
A
A
T
M
F
G
NA
G
V
F
A
W
F
SY
V
K
P
Y
M
M
F
I
S
G
F
S
ET
A
M
T
F
I
M
M
L
V
G
L
G
MV
L
GN
V
L
S
G
R
I
SG
RY
SPLRIA
A
VTD
F
II
VL
AL
LML
F
--
F
F
G
GM
K
TTSL
I
F
---
AFI
CC
A
G
L
FA
L
SA
PLQ
I
L
L
L
QN
A
KG
G
EL
L
GA
A
GGQ
I
AFNLG
S
A
V
GA
YC
GG
M
M
L
T
-
LGL
A
Y
N
Y
V
ALP
A
A
L
LS
FAA
M
S
-
SLL
L
Y
G
R
YKR
Q
fig|656393.3.peg.1040
Escherichia coli H299 (33-409/422)
IL
S
LALG
T
FG
L
G
MA
EF
G
I
MG
V
L
TE
L
A
HN
V
G
I
SIPAAG
H
MIS
Y
YA
L
GV
V
VGAP
IIA
L
FS
S
RYS
LK
HI
L
L
FL
V
AL
C
VI
GN
AMF
T
LS
S
SY
LM
L
A
I
G
R
L
VSG
F
P
HGAFFG
V
GA
I
V
L
SK
I
I
K
P
GK
V
T
A
AVA
G
M
VS
G
M
T
V
AN
L
LG
I
PLGT
Y
L
S
Q
E
F
S
WR
Y
TFL
L
IA
VFN
I
A
V
M
A
S
V
YFW
V
P
DIRD
EA
K
G
K
L
-
R
EQFHF
LR
S
PA
PW
L
I
F
A
A
T
M
F
G
NA
G
V
F
A
W
F
SY
V
K
P
Y
M
M
F
I
S
G
F
S
ET
A
M
T
F
I
M
M
L
V
G
L
G
MV
L
GN
V
L
S
G
R
I
SG
RY
SPLRIA
A
VTD
F
II
VL
AL
LML
F
--
F
F
G
GM
K
TTSL
I
F
---
AFI
CC
A
G
L
FA
L
SA
PLQ
I
L
L
L
QN
A
KG
G
EL
L
GA
A
GGQ
I
AFNLG
S
A
V
GA
YC
GG
M
M
L
T
-
LGL
A
Y
N
Y
V
ALP
A
A
L
LS
FAA
M
S
-
SLL
L
Y
G
R
YKR
Q
fig|358709.5.peg.3599
Escherichia coli 101-1 (33-409/422)
IL
S
LALG
T
FG
L
G
MA
EF
G
I
MG
V
L
TE
L
A
HN
V
G
I
SIPAAG
H
MIS
Y
YA
L
GV
V
VGAP
IIA
L
FS
S
RYS
LK
HI
L
L
FL
V
AL
C
VI
GN
AMF
T
LS
S
SY
LM
L
A
I
G
R
L
VSG
F
P
HGAFFG
V
GA
I
V
L
SK
I
I
K
P
GK
V
T
A
AVA
G
M
VS
G
M
T
V
AN
L
LG
I
PLGT
Y
L
S
Q
E
F
S
WR
Y
TFL
L
IA
VFN
I
A
V
M
A
S
V
YFW
V
P
DICD
EA
K
G
N
L
-
R
EQFHF
LR
S
PA
PW
L
I
F
A
A
T
M
F
G
NA
G
V
F
A
W
F
SY
V
K
P
Y
M
M
F
I
S
G
F
S
ET
A
M
T
F
I
M
M
L
V
G
L
G
MV
L
GN
M
L
S
G
R
I
SG
RY
SPLRIA
A
VTD
F
II
VL
AL
LML
F
--
F
C
G
GM
K
TTSL
I
F
---
AFI
CC
A
G
L
FA
L
SA
PLQ
I
L
L
L
QN
A
KG
G
EL
L
GA
A
GGQ
I
AFNLG
S
A
V
GA
YC
GG
M
M
L
T
-
LGL
A
Y
N
Y
V
ALP
A
A
L
LS
FAA
M
S
-
SLL
L
Y
G
R
YKR
Q
fig|413997.3.peg.367
Escherichia coli B str. REL606 (33-409/422)
IL
S
LALG
T
FG
L
G
MA
EF
G
I
MG
V
L
TE
L
A
HN
V
G
I
SIPAAG
H
MIS
Y
YA
L
GV
V
VGAP
IIA
L
FS
S
RYS
LK
HI
L
L
FL
V
AL
C
VI
GN
AMF
T
LS
S
SY
LM
L
A
I
G
R
L
VSG
F
P
HGAFFG
V
GA
I
V
L
SK
I
I
K
P
GK
V
T
A
AVA
G
M
VS
G
M
T
V
AN
L
LG
I
PLGT
Y
L
S
Q
E
F
S
WR
Y
TFL
L
IA
VFN
I
A
V
M
A
S
V
YFW
V
P
DICD
EA
K
G
N
L
-
R
EQFHF
LR
S
PA
PW
L
I
F
A
A
T
M
F
G
NA
G
V
F
A
W
F
SY
V
K
P
Y
M
M
F
I
S
G
F
S
ET
A
M
T
F
I
M
M
L
V
G
L
G
MV
L
GN
M
L
S
G
R
I
SG
RY
SPLRIA
A
VTD
F
II
VL
AL
LML
F
--
F
C
G
GM
K
TTSL
I
F
---
AFI
CC
A
G
L
FA
L
SA
PLQ
I
L
L
L
QN
A
KG
G
EL
L
GA
A
GGQ
I
AFNLG
S
A
V
GA
YC
GG
M
M
L
T
-
LGL
A
Y
N
Y
V
ALP
A
A
L
LS
FAA
M
S
-
SLL
L
Y
G
R
YKR
Q
fig|511693.5.peg.373
Escherichia coli BL21 (33-409/422)
IL
S
LALG
T
FG
L
G
MA
EF
G
I
MG
V
L
TE
L
A
HN
V
G
I
SIPAAG
H
MIS
Y
YA
L
GV
V
VGAP
IIA
L
FS
S
RYS
LK
HI
L
L
FL
V
AL
C
VI
GN
AMF
T
LS
S
SY
LM
L
A
I
G
R
L
VSG
F
P
HGAFFG
V
GA
I
V
L
SK
I
I
K
P
GK
V
T
A
AVA
G
M
VS
G
M
T
V
AN
L
LG
I
PLGT
Y
L
S
Q
E
F
S
WR
Y
TFL
L
IA
VFN
I
A
V
M
A
S
V
YFW
V
P
DICD
EA
K
G
N
L
-
R
EQFHF
LR
S
PA
PW
L
I
F
A
A
T
M
F
G
NA
G
V
F
A
W
F
SY
V
K
P
Y
M
M
F
I
S
G
F
S
ET
A
M
T
F
I
M
M
L
V
G
L
G
MV
L
GN
M
L
S
G
R
I
SG
RY
SPLRIA
A
VTD
F
II
VL
AL
LML
F
--
F
C
G
GM
K
TTSL
I
F
---
AFI
CC
A
G
L
FA
L
SA
PLQ
I
L
L
L
QN
A
KG
G
EL
L
GA
A
GGQ
I
AFNLG
S
A
V
GA
YC
GG
M
M
L
T
-
LGL
A
Y
N
Y
V
ALP
A
A
L
LS
FAA
M
S
-
SLL
L
Y
G
R
YKR
Q
fig|469008.4.peg.3376
Escherichia coli BL21(DE3) (33-409/422)
IL
S
LALG
T
FG
L
G
MA
EF
G
I
MG
V
L
TE
L
A
HN
V
G
I
SIPAAG
H
MIS
Y
YA
L
GV
V
VGAP
IIA
L
FS
S
RYS
LK
HI
L
L
FL
V
AL
C
VI
GN
AMF
T
LS
S
SY
LM
L
A
I
G
R
L
VSG
F
P
HGAFFG
V
GA
I
V
L
SK
I
I
K
P
GK
V
T
A
AVA
G
M
VS
G
M
T
V
AN
L
LG
I
PLGT
Y
L
S
Q
E
F
S
WR
Y
TFL
L
IA
VFN
I
A
V
M
A
S
V
YFW
V
P
DICD
EA
K
G
N
L
-
R
EQFHF
LR
S
PA
PW
L
I
F
A
A
T
M
F
G
NA
G
V
F
A
W
F
SY
V
K
P
Y
M
M
F
I
S
G
F
S
ET
A
M
T
F
I
M
M
L
V
G
L
G
MV
L
GN
M
L
S
G
R
I
SG
RY
SPLRIA
A
VTD
F
II
VL
AL
LML
F
--
F
C
G
GM
K
TTSL
I
F
---
AFI
CC
A
G
L
FA
L
SA
PLQ
I
L
L
L
QN
A
KG
G
EL
L
GA
A
GGQ
I
AFNLG
S
A
V
GA
YC
GG
M
M
L
T
-
LGL
A
Y
N
Y
V
ALP
A
A
L
LS
FAA
M
S
-
SLL
L
Y
G
R
YKR
Q
fig|749533.3.peg.1408
Escherichia coli MS 84-1 (33-409/422)
IL
S
LALG
T
FG
L
G
MA
EF
G
I
MG
V
L
TE
L
A
HN
V
G
I
SIPAAG
H
MIS
Y
YA
L
GV
V
VGAP
IIA
L
FS
S
RYS
LK
HI
L
L
FL
V
AL
C
VI
GN
AMF
T
LS
S
SY
MM
L
A
I
G
R
L
VSG
F
P
HGAFFG
V
GA
I
V
L
SK
I
I
K
P
GK
V
T
A
AVA
G
V
VS
G
M
T
V
AN
L
LG
I
PLGT
Y
L
S
Q
E
F
S
WR
Y
TFL
L
IA
VFN
I
A
V
M
A
S
V
YFW
V
P
DIRD
EA
K
G
K
L
-
R
EQFHF
LR
S
PA
PW
L
I
F
A
A
T
M
F
G
NA
G
V
F
A
W
F
SY
V
K
P
Y
M
M
F
I
S
G
F
S
ET
A
M
T
F
I
M
M
L
V
G
L
G
MV
L
GN
M
L
S
G
R
I
SG
RY
SPLRIA
A
VTD
F
II
VL
AL
LML
F
--
F
C
G
GM
K
TTSL
I
F
---
AFI
CC
A
G
L
FA
L
SA
PLQ
I
L
L
L
QN
A
KG
G
EL
L
GA
A
GGQ
I
AFNLG
S
A
V
GA
YC
GG
M
M
L
T
-
LGL
A
Y
N
Y
V
ALP
A
A
L
LS
FAA
M
S
-
SLL
L
Y
G
R
YKR
Q
fig|550672.3.peg.410
Escherichia coli B088 (33-409/422)
IL
S
LALG
T
FG
L
G
MA
EF
G
I
MG
V
L
TE
L
A
HN
V
G
I
SIPAAG
H
MIS
Y
YA
L
GV
V
VGAP
IIA
L
FS
S
RYS
LK
HI
L
L
FL
V
AL
C
VI
GN
AMF
T
LS
S
SY
LM
L
A
I
G
R
L
VSG
F
P
HGAFFG
V
GA
I
V
L
SK
I
I
K
P
GK
V
T
A
AVA
G
M
VS
G
M
T
V
AN
L
LG
I
PLGT
Y
L
S
Q
E
F
S
WR
Y
TFL
L
IA
VFN
I
A
V
M
A
S
V
YFW
V
P
DIRD
EA
K
G
K
L
-
R
EQFHF
LR
S
PA
PW
L
I
F
A
A
T
M
F
G
NA
G
V
F
A
W
F
SY
V
K
P
Y
M
M
F
I
S
G
F
S
ET
A
M
T
F
I
M
M
L
V
G
L
G
MV
L
GN
M
L
S
G
R
I
SG
RY
SPLRIA
A
VTD
F
II
VL
AL
LML
F
--
F
C
G
GM
K
TTSL
I
F
---
AFI
CC
A
G
L
FA
L
SA
PLQ
I
L
L
L
QN
A
KG
G
EL
L
GA
A
GGQ
I
AFNLG
S
A
V
GA
YC
GG
M
M
L
T
-
LGL
A
Y
N
Y
V
ALP
A
A
L
LS
FAA
M
S
-
SLL
L
Y
G
R
YKR
Q
fig|550676.3.peg.1185
Escherichia coli B185 (33-409/422)
IL
S
LALG
T
FG
L
G
MA
EF
G
I
MG
V
L
TE
L
A
HN
V
G
I
SIPAAG
H
MIS
Y
YA
L
GV
V
VGAP
IIA
L
FS
S
RYS
LK
HI
L
L
FL
V
AL
C
VI
GN
AMF
T
LS
S
SY
LM
L
A
I
G
R
L
VSG
F
P
HGAFFG
V
GA
I
V
L
SK
I
I
K
P
GK
V
T
A
AVA
G
M
VS
G
M
T
V
AN
L
LG
I
PLGT
Y
L
S
Q
E
F
S
WR
Y
TFL
L
IA
VFN
I
A
V
M
A
S
V
YFW
V
P
DIRD
EA
K
G
K
L
-
R
EQFHF
LR
S
PA
PW
L
I
F
A
A
T
M
F
G
NA
G
V
F
A
W
F
SY
V
K
P
Y
M
M
F
I
S
G
F
S
ET
A
M
T
F
I
M
M
L
V
G
L
G
MV
L
GN
M
L
S
G
R
I
SG
RY
SPLRIA
A
VTD
F
II
VL
AL
LML
F
--
F
C
G
GM
K
TTSL
I
F
---
AFI
CC
A
G
L
FA
L
SA
PLQ
I
L
L
L
QN
A
KG
G
EL
L
GA
A
GGQ
I
AFNLG
S
A
V
GA
YC
GG
M
M
L
T
-
LGL
A
Y
N
Y
V
ALP
A
A
L
LS
FAA
M
S
-
SLL
L
Y
G
R
YKR
Q
fig|595495.4.peg.481
Escherichia coli KO11 (33-409/422)
IL
S
LALG
T
FG
L
G
MA
EF
G
I
MG
V
L
TE
L
A
HN
V
G
I
SIPAAG
H
MIS
Y
YA
L
GV
V
VGAP
IIA
L
FS
S
RYS
LK
HI
L
L
FL
V
AL
C
VI
GN
AMF
T
LS
S
SY
LM
L
A
I
G
R
L
VSG
F
P
HGAFFG
V
GA
I
V
L
SK
I
I
K
P
GK
V
T
A
AVA
G
M
VS
G
M
T
V
AN
L
LG
I
PLGT
Y
L
S
Q
E
F
S
WR
Y
TFL
L
IA
VFN
I
A
V
M
A
S
V
YFW
V
P
DIRD
EA
K
G
K
L
-
R
EQFHF
LR
S
PA
PW
L
I
F
A
A
T
M
F
G
NA
G
V
F
A
W
F
SY
V
K
P
Y
M
M
F
I
S
G
F
S
ET
A
M
T
F
I
M
M
L
V
G
L
G
MV
L
GN
M
L
S
G
R
I
SG
RY
SPLRIA
A
VTD
F
II
VL
AL
LML
F
--
F
C
G
GM
K
TTSL
I
F
---
AFI
CC
A
G
L
FA
L
SA
PLQ
I
L
L
L
QN
A
KG
G
EL
L
GA
A
GGQ
I
AFNLG
S
A
V
GA
YC
GG
M
M
L
T
-
LGL
A
Y
N
Y
V
ALP
A
A
L
LS
FAA
M
S
-
SLL
L
Y
G
R
YKR
Q
fig|656419.3.peg.593
Escherichia coli M718 (33-409/422)
IL
S
LALG
T
FG
L
G
MA
EF
G
I
MG
V
L
TE
L
A
HN
V
G
I
SIPAAG
H
MIS
Y
YA
L
GV
V
VGAP
IIA
L
FS
S
RYS
LK
HI
L
L
FL
V
AL
C
VI
GN
AMF
T
LS
S
SY
LM
L
A
I
G
R
L
VSG
F
P
HGAFFG
V
GA
I
V
L
SK
I
I
K
P
GK
V
T
A
AVA
G
M
VS
G
M
T
V
AN
L
LG
I
PLGT
Y
L
S
Q
E
F
S
WR
Y
TFL
L
IA
VFN
I
A
V
M
A
S
V
YFW
V
P
DIRD
EA
K
G
K
L
-
R
EQFHF
LR
S
PA
PW
L
I
F
A
A
T
M
F
G
NA
G
V
F
A
W
F
SY
V
K
P
Y
M
M
F
I
S
G
F
S
ET
A
M
T
F
I
M
M
L
V
G
L
G
MV
L
GN
M
L
S
G
R
I
SG
RY
SPLRIA
A
VTD
F
II
VL
AL
LML
F
--
F
C
G
GM
K
TTSL
I
F
---
AFI
CC
A
G
L
FA
L
SA
PLQ
I
L
L
L
QN
A
KG
G
EL
L
GA
A
GGQ
I
AFNLG
S
A
V
GA
YC
GG
M
M
L
T
-
LGL
A
Y
N
Y
V
ALP
A
A
L
LS
FAA
M
S
-
SLL
L
Y
G
R
YKR
Q
fig|679207.4.peg.3238
Escherichia coli MS 107-1 (33-409/422)
IL
S
LALG
T
FG
L
G
MA
EF
G
I
MG
V
L
TE
L
A
HN
V
G
I
SIPAAG
H
MIS
Y
YA
L
GV
V
VGAP
IIA
L
FS
S
RYS
LK
HI
L
L
FL
V
AL
C
VI
GN
AMF
T
LS
S
SY
LM
L
A
I
G
R
L
VSG
F
P
HGAFFG
V
GA
I
V
L
SK
I
I
K
P
GK
V
T
A
AVA
G
M
VS
G
M
T
V
AN
L
LG
I
PLGT
Y
L
S
Q
E
F
S
WR
Y
TFL
L
IA
VFN
I
A
V
M
A
S
V
YFW
V
P
DIRD
EA
K
G
K
L
-
R
EQFHF
LR
S
PA
PW
L
I
F
A
A
T
M
F
G
NA
G
V
F
A
W
F
SY
V
K
P
Y
M
M
F
I
S
G
F
S
ET
A
M
T
F
I
M
M
L
V
G
L
G
MV
L
GN
M
L
S
G
R
I
SG
RY
SPLRIA
A
VTD
F
II
VL
AL
LML
F
--
F
C
G
GM
K
TTSL
I
F
---
AFI
CC
A
G
L
FA
L
SA
PLQ
I
L
L
L
QN
A
KG
G
EL
L
GA
A
GGQ
I
AFNLG
S
A
V
GA
YC
GG
M
M
L
T
-
LGL
A
Y
N
Y
V
ALP
A
A
L
LS
FAA
M
S
-
SLL
L
Y
G
R
YKR
Q
fig|749545.3.peg.2164
Escherichia coli MS 182-1 (33-409/422)
IL
S
LALG
T
FG
L
G
MA
EF
G
I
MG
V
L
TE
L
A
HN
V
G
I
SIPAAG
H
MIS
Y
YA
L
GV
V
VGAP
IIA
L
FS
S
RYS
LK
HI
L
L
FL
V
AL
C
VI
GN
AMF
T
LS
S
SY
LM
L
A
I
G
R
L
VSG
F
P
HGAFFG
V
GA
I
V
L
SK
I
I
K
P
GK
V
T
A
AVA
G
M
VS
G
M
T
V
AN
L
LG
I
PLGT
Y
L
S
Q
E
F
S
WR
Y
TFL
L
IA
VFN
I
A
V
M
A
S
V
YFW
V
P
DIRD
EA
K
G
K
L
-
R
EQFHF
LR
S
PA
PW
L
I
F
A
A
T
M
F
G
NA
G
V
F
A
W
F
SY
V
K
P
Y
M
M
F
I
S
G
F
S
ET
A
M
T
F
I
M
M
L
V
G
L
G
MV
L
GN
M
L
S
G
R
I
SG
RY
SPLRIA
A
VTD
F
II
VL
AL
LML
F
--
F
C
G
GM
K
TTSL
I
F
---
AFI
CC
A
G
L
FA
L
SA
PLQ
I
L
L
L
QN
A
KG
G
EL
L
GA
A
GGQ
I
AFNLG
S
A
V
GA
YC
GG
M
M
L
T
-
LGL
A
Y
N
Y
V
ALP
A
A
L
LS
FAA
M
S
-
SLL
L
Y
G
R
YKR
Q
fig|566546.3.peg.2396
Escherichia coli W (33-409/422)
IL
S
LALG
T
FG
L
G
MA
EF
G
I
MG
V
L
TE
L
A
HN
V
G
I
SIPAAG
H
MIS
Y
YA
L
GV
V
VGAP
IIA
L
FS
S
RYS
LK
HI
L
L
FL
V
AL
C
VI
GN
AMF
T
LS
S
SY
LM
L
A
I
G
R
L
VSG
F
P
HGAFFG
V
GA
I
V
L
SK
I
I
K
P
GK
V
T
A
AVA
G
M
VS
G
M
T
V
AN
L
LG
I
PLGT
Y
L
S
Q
E
F
S
WR
Y
TFL
L
IA
VFN
I
A
V
M
A
S
V
YFW
V
P
DIRD
EA
K
G
K
L
-
R
EQFHF
LR
S
PA
PW
L
I
F
A
A
T
M
F
G
NA
G
V
F
A
W
F
SY
V
K
P
Y
M
M
F
I
S
G
F
S
ET
A
M
T
F
I
M
M
L
V
G
L
G
MV
L
GN
M
L
S
G
R
I
SG
RY
SPLRIA
A
VTD
F
II
VL
AL
LML
F
--
F
C
G
GM
K
TTSL
I
F
---
AFI
CC
A
G
L
FA
L
SA
PLQ
I
L
L
L
QN
A
KG
G
EL
L
GA
A
GGQ
I
AFNLG
S
A
V
GA
YC
GG
M
M
L
T
-
LGL
A
Y
N
Y
V
ALP
A
A
L
LS
FAA
M
S
-
SLL
L
Y
G
R
YKR
Q
fig|566546.4.peg.467
Escherichia coli W (33-409/422)
IL
S
LALG
T
FG
L
G
MA
EF
G
I
MG
V
L
TE
L
A
HN
V
G
I
SIPAAG
H
MIS
Y
YA
L
GV
V
VGAP
IIA
L
FS
S
RYS
LK
HI
L
L
FL
V
AL
C
VI
GN
AMF
T
LS
S
SY
LM
L
A
I
G
R
L
VSG
F
P
HGAFFG
V
GA
I
V
L
SK
I
I
K
P
GK
V
T
A
AVA
G
M
VS
G
M
T
V
AN
L
LG
I
PLGT
Y
L
S
Q
E
F
S
WR
Y
TFL
L
IA
VFN
I
A
V
M
A
S
V
YFW
V
P
DIRD
EA
K
G
K
L
-
R
EQFHF
LR
S
PA
PW
L
I
F
A
A
T
M
F
G
NA
G
V
F
A
W
F
SY
V
K
P
Y
M
M
F
I
S
G
F
S
ET
A
M
T
F
I
M
M
L
V
G
L
G
MV
L
GN
M
L
S
G
R
I
SG
RY
SPLRIA
A
VTD
F
II
VL
AL
LML
F
--
F
C
G
GM
K
TTSL
I
F
---
AFI
CC
A
G
L
FA
L
SA
PLQ
I
L
L
L
QN
A
KG
G
EL
L
GA
A
GGQ
I
AFNLG
S
A
V
GA
YC
GG
M
M
L
T
-
LGL
A
Y
N
Y
V
ALP
A
A
L
LS
FAA
M
S
-
SLL
L
Y
G
R
YKR
Q
fig|216592.1.peg.4829
Escherichia coli 042 (33-409/422)
IL
S
LALG
T
FG
L
G
MA
EF
G
I
MG
V
L
TE
L
A
HN
V
G
I
SIPAAG
H
MIS
Y
YA
L
GV
V
VGAP
IIA
L
FS
S
RYS
LK
HI
L
L
FL
V
AL
C
VI
GN
AMF
T
LS
S
SY
LM
L
A
I
G
R
L
VSG
F
P
HGAFFG
V
GA
I
V
L
SK
I
I
K
P
GK
V
T
A
AVA
G
M
VS
G
M
T
V
AN
L
LG
I
PLGT
Y
L
S
Q
E
F
S
WR
Y
TFL
L
IA
VFN
I
A
V
M
A
S
V
YFW
V
P
DIRD
EA
K
G
K
L
-
R
EQFHF
LR
S
PA
PW
L
I
F
A
A
T
M
F
G
NA
G
V
F
A
W
F
SY
V
K
P
Y
M
M
F
I
S
G
F
S
ET
A
M
T
F
I
M
M
L
V
G
L
G
MV
L
GN
V
L
S
G
R
I
SG
RY
SPLRIA
A
VTD
F
II
VL
AL
LML
F
--
F
F
G
GM
K
TTSL
I
F
---
AFF
CC
A
G
L
FA
L
SA
PLQ
I
L
L
L
QN
A
KG
G
EL
L
GA
A
GGQ
I
AFNLG
S
A
V
GA
YC
GG
M
M
L
T
-
LGL
A
Y
N
Y
V
ALP
A
A
L
LS
FAA
M
S
-
SLL
L
Y
G
R
YKR
Q
fig|216592.3.peg.450
Escherichia coli 042 (33-409/422)
IL
S
LALG
T
FG
L
G
MA
EF
G
I
MG
V
L
TE
L
A
HN
V
G
I
SIPAAG
H
MIS
Y
YA
L
GV
V
VGAP
IIA
L
FS
S
RYS
LK
HI
L
L
FL
V
AL
C
VI
GN
AMF
T
LS
S
SY
LM
L
A
I
G
R
L
VSG
F
P
HGAFFG
V
GA
I
V
L
SK
I
I
K
P
GK
V
T
A
AVA
G
M
VS
G
M
T
V
AN
L
LG
I
PLGT
Y
L
S
Q
E
F
S
WR
Y
TFL
L
IA
VFN
I
A
V
M
A
S
V
YFW
V
P
DIRD
EA
K
G
K
L
-
R
EQFHF
LR
S
PA
PW
L
I
F
A
A
T
M
F
G
NA
G
V
F
A
W
F
SY
V
K
P
Y
M
M
F
I
S
G
F
S
ET
A
M
T
F
I
M
M
L
V
G
L
G
MV
L
GN
V
L
S
G
R
I
SG
RY
SPLRIA
A
VTD
F
II
VL
AL
LML
F
--
F
F
G
GM
K
TTSL
I
F
---
AFF
CC
A
G
L
FA
L
SA
PLQ
I
L
L
L
QN
A
KG
G
EL
L
GA
A
GGQ
I
AFNLG
S
A
V
GA
YC
GG
M
M
L
T
-
LGL
A
Y
N
Y
V
ALP
A
A
L
LS
FAA
M
S
-
SLL
L
Y
G
R
YKR
Q
fig|656379.3.peg.871
Escherichia coli FVEC1302 (33-409/422)
IL
S
LALG
T
FG
L
G
MA
EF
G
I
MG
V
L
TE
L
A
HN
V
G
I
SIPAAG
H
MIS
Y
YA
L
GV
V
VGAP
IIA
L
FS
S
RYS
LK
HI
L
L
FL
V
AL
C
VI
GN
AMF
T
LS
S
SY
LM
L
A
I
G
R
L
VSG
F
P
HGAFFG
V
GA
I
V
L
SK
I
I
K
P
GK
V
T
A
AVA
G
M
VS
G
M
T
V
AN
L
LG
I
PLGT
Y
L
S
Q
E
F
S
WR
Y
TFL
L
IA
VFN
I
A
V
M
A
S
V
YFW
V
P
DIRD
EA
K
G
K
L
-
R
EQFHF
LR
S
PA
PW
L
I
F
A
A
T
M
F
G
NA
G
V
F
A
W
F
SY
V
K
P
Y
M
M
F
I
S
G
F
S
ET
A
M
T
F
I
M
M
L
V
G
L
G
MV
L
GN
V
L
S
G
R
I
SG
RY
SPLRIA
A
VTD
F
II
VL
AL
LML
F
--
F
F
G
GM
K
TTSL
I
F
---
AFF
CC
A
G
L
FA
L
SA
PLQ
I
L
L
L
QN
A
KG
G
EL
L
GA
A
GGQ
I
AFNLG
S
A
V
GA
YC
GG
M
M
L
T
-
LGL
A
Y
N
Y
V
ALP
A
A
L
LS
FAA
M
S
-
SLL
L
Y
G
R
YKR
Q
fig|656380.3.peg.1021
Escherichia coli FVEC1412 (33-409/422)
IL
S
LALG
T
FG
L
G
MA
EF
G
I
MG
V
L
TE
L
A
HN
V
G
I
SIPAAG
H
MIS
Y
YA
L
GV
V
VGAP
IIA
L
FS
S
RYS
LK
HI
L
L
FL
V
AL
C
VI
GN
AMF
T
LS
S
SY
LM
L
A
I
G
R
L
VSG
F
P
HGAFFG
V
GA
I
V
L
SK
I
I
K
P
GK
V
T
A
AVA
G
M
VS
G
M
T
V
AN
L
LG
I
PLGT
Y
L
S
Q
E
F
S
WR
Y
TFL
L
IA
VFN
I
A
V
M
A
S
V
YFW
V
P
DIRD
EA
K
G
K
L
-
R
EQFHF
LR
S
PA
PW
L
I
F
A
A
T
M
F
G
NA
G
V
F
A
W
F
SY
V
K
P
Y
M
M
F
I
S
G
F
S
ET
A
M
T
F
I
M
M
L
V
G
L
G
MV
L
GN
V
L
S
G
R
I
SG
RY
SPLRIA
A
VTD
F
II
VL
AL
LML
F
--
F
F
G
GM
K
TTSL
I
F
---
AFF
CC
A
G
L
FA
L
SA
PLQ
I
L
L
L
QN
A
KG
G
EL
L
GA
A
GGQ
I
AFNLG
S
A
V
GA
YC
GG
M
M
L
T
-
LGL
A
Y
N
Y
V
ALP
A
A
L
LS
FAA
M
S
-
SLL
L
Y
G
R
YKR
Q
fig|749549.3.peg.4260
Escherichia coli MS 198-1 (33-409/422)
IL
S
LALG
T
FG
L
G
MA
EF
G
I
MG
V
L
TE
L
A
HN
V
G
I
SIPAAG
H
MIS
Y
YA
L
GV
V
VGAP
IIA
L
FS
S
RYS
LK
HI
L
L
FL
V
AL
C
VI
GN
AMF
T
LS
S
SY
LM
L
A
I
G
R
L
VSG
F
P
HGAFFG
V
GA
I
V
L
SK
I
I
K
P
GK
V
T
A
AVA
G
M
VS
G
M
T
V
AN
L
LG
I
PLGT
Y
L
S
Q
E
F
S
WR
Y
TFL
L
IA
VFN
I
A
V
M
A
S
V
YFW
V
P
DIRD
EA
K
G
K
L
-
R
EQFHF
LR
S
PA
PW
L
I
F
A
A
T
M
F
G
NA
G
V
F
A
W
F
SY
V
K
P
Y
M
M
F
I
S
G
F
S
ET
A
M
T
F
I
M
M
L
V
G
L
G
MV
L
GN
V
L
S
G
R
I
SG
RY
SPLRIA
A
VTD
F
II
VL
AL
LML
F
--
F
F
G
GM
K
TTSL
I
F
---
AFF
CC
A
G
L
FA
L
SA
PLQ
I
L
L
L
QN
A
KG
G
EL
L
GA
A
GGQ
I
AFNLG
S
A
V
GA
YC
GG
M
M
L
T
-
LGL
A
Y
N
Y
V
ALP
A
A
L
LS
FAA
M
S
-
SLL
L
Y
G
R
YKR
Q
fig|585056.7.peg.633
Escherichia coli UMN026 (33-409/422)
IL
S
LALG
T
FG
L
G
MA
EF
G
I
MG
V
L
TE
L
A
HN
V
G
I
SIPAAG
H
MIS
Y
YA
L
GV
V
VGAP
IIA
L
FS
S
RYS
LK
HI
L
L
FL
V
AL
C
VI
GN
AMF
T
LS
S
SY
LM
L
A
I
G
R
L
VSG
F
P
HGAFFG
V
GA
I
V
L
SK
I
I
K
P
GK
V
T
A
AVA
G
M
VS
G
M
T
V
AN
L
LG
I
PLGT
Y
L
S
Q
E
F
S
WR
Y
TFL
L
IA
VFN
I
A
V
M
A
S
V
YFW
V
P
DIRD
EA
K
G
K
L
-
R
EQFHF
LR
S
PA
PW
L
I
F
A
A
T
M
F
G
NA
G
V
F
A
W
F
SY
V
K
P
Y
M
M
F
I
S
G
F
S
ET
A
M
T
F
I
M
M
L
V
G
L
G
MV
L
GN
V
L
S
G
R
I
SG
RY
SPLRIA
A
VTD
F
II
VL
AL
LML
F
--
F
F
G
GM
K
TTSL
I
F
---
AFF
CC
A
G
L
FA
L
SA
PLQ
I
L
L
L
QN
A
KG
G
EL
L
GA
A
GGQ
I
AFNLG
S
A
V
GA
YC
GG
M
M
L
T
-
LGL
A
Y
N
Y
V
ALP
A
A
L
LS
FAA
M
S
-
SLL
L
Y
G
R
YKR
Q
fig|585034.4.peg.387
Escherichia coli IAI1 (33-409/422)
IL
S
LALG
T
FG
L
G
MA
EF
G
I
MG
V
L
TE
L
A
HN
V
G
I
SIPAAG
H
MIS
Y
YA
L
GV
V
VGAP
IIA
L
FS
S
RYS
LK
HI
L
L
FL
V
AL
C
VI
GN
AMF
T
LS
S
SY
LM
L
A
I
G
R
L
VSG
F
P
HGAFFG
V
GA
I
V
L
SK
I
I
K
P
GK
V
T
A
AVA
G
M
VS
G
M
T
V
AN
L
LG
I
PLGT
Y
L
S
Q
E
F
S
WR
Y
TFL
L
IA
VFN
I
A
V
M
A
S
V
YFW
V
P
DIRD
EA
K
G
K
L
-
R
EQFHF
LR
S
PA
PW
L
I
F
A
A
T
M
F
G
NA
G
V
F
A
W
F
SY
V
K
P
Y
M
M
F
I
S
G
F
S
ET
A
M
T
F
I
M
M
L
V
G
L
G
MV
L
GN
M
L
S
G
R
V
SG
RY
SPLRIA
A
VTD
F
II
VL
AL
LML
F
--
F
F
G
GM
K
TTSL
I
F
---
AFI
CC
A
G
L
FA
L
SA
PLQ
I
L
L
L
QN
A
KG
G
EL
L
GA
A
GGQ
I
AFNLG
S
A
V
GA
YC
GG
M
M
L
T
-
LGL
A
Y
N
Y
V
ALP
A
A
L
LS
FAA
M
S
-
SLL
L
Y
G
R
YKR
Q
fig|585034.5.peg.386
Escherichia coli IAI1 (33-409/422)
IL
S
LALG
T
FG
L
G
MA
EF
G
I
MG
V
L
TE
L
A
HN
V
G
I
SIPAAG
H
MIS
Y
YA
L
GV
V
VGAP
IIA
L
FS
S
RYS
LK
HI
L
L
FL
V
AL
C
VI
GN
AMF
T
LS
S
SY
LM
L
A
I
G
R
L
VSG
F
P
HGAFFG
V
GA
I
V
L
SK
I
I
K
P
GK
V
T
A
AVA
G
M
VS
G
M
T
V
AN
L
LG
I
PLGT
Y
L
S
Q
E
F
S
WR
Y
TFL
L
IA
VFN
I
A
V
M
A
S
V
YFW
V
P
DIRD
EA
K
G
K
L
-
R
EQFHF
LR
S
PA
PW
L
I
F
A
A
T
M
F
G
NA
G
V
F
A
W
F
SY
V
K
P
Y
M
M
F
I
S
G
F
S
ET
A
M
T
F
I
M
M
L
V
G
L
G
MV
L
GN
M
L
S
G
R
V
SG
RY
SPLRIA
A
VTD
F
II
VL
AL
LML
F
--
F
F
G
GM
K
TTSL
I
F
---
AFI
CC
A
G
L
FA
L
SA
PLQ
I
L
L
L
QN
A
KG
G
EL
L
GA
A
GGQ
I
AFNLG
S
A
V
GA
YC
GG
M
M
L
T
-
LGL
A
Y
N
Y
V
ALP
A
A
L
LS
FAA
M
S
-
SLL
L
Y
G
R
YKR
Q
fig|670888.3.peg.972
Escherichia coli 1827-70 (33-409/422)
IL
S
LALG
T
FG
L
G
MA
EF
G
I
MG
V
L
TE
L
A
HN
V
G
I
SIPAAG
H
MIS
Y
YA
L
GV
V
VGAP
IIA
L
FS
S
RYS
LK
HI
L
L
FL
V
AL
C
VI
GN
AMF
T
LS
S
SY
LM
L
A
I
G
R
L
VSG
F
P
HGAFFG
V
GA
I
V
L
SK
I
I
K
P
GK
V
T
A
AVA
G
M
VS
G
M
T
V
AN
L
LG
I
PLGT
Y
L
S
Q
E
F
S
WR
Y
TFL
L
IA
VFN
I
A
V
M
A
S
V
YFW
V
P
DIRD
EA
K
G
N
L
-
R
EQFHF
LR
S
PA
PW
L
I
F
A
A
T
M
F
G
NA
G
V
F
A
W
F
SY
V
K
P
Y
M
M
F
I
S
G
F
S
ET
A
M
T
F
I
M
M
L
V
G
L
G
MV
L
GN
M
L
S
G
R
I
SG
RY
SPLRIA
A
VTD
F
II
VL
AL
LML
F
--
F
C
G
GM
K
TTSL
I
F
---
AFI
CC
A
G
L
FA
L
SA
PLQ
I
L
L
L
QN
A
KG
G
EL
L
GA
A
GGQ
I
AFNLG
S
A
V
GA
YC
GG
M
M
L
T
-
LGL
A
Y
N
Y
V
ALP
A
A
L
LS
FAA
M
S
-
SLL
L
Y
G
R
YKR
Q
fig|481805.6.peg.3458
Escherichia coli ATCC 8739 (33-409/422)
IL
S
LALG
T
FG
L
G
MA
EF
G
I
MG
V
L
TE
L
A
HN
V
G
I
SIPAAG
H
MIS
Y
YA
L
GV
V
VGAP
IIA
L
FS
S
RYS
LK
HI
L
L
FL
V
AL
C
VI
GN
AMF
T
LS
S
SY
LM
L
A
I
G
R
L
VSG
F
P
HGAFFG
V
GA
I
V
L
SK
I
I
K
P
GK
V
T
A
AVA
G
M
VS
G
M
T
V
AN
L
LG
I
PLGT
Y
L
S
Q
E
F
S
WR
Y
TFL
L
IA
VFN
I
A
V
M
A
S
V
YFW
V
P
DIRD
EA
K
G
N
L
-
R
EQFHF
LR
S
PA
PW
L
I
F
A
A
T
M
F
G
NA
G
V
F
A
W
F
SY
V
K
P
Y
M
M
F
I
S
G
F
S
ET
A
M
T
F
I
M
M
L
V
G
L
G
MV
L
GN
M
L
S
G
R
I
SG
RY
SPLRIA
A
VTD
F
II
VL
AL
LML
F
--
F
C
G
GM
K
TTSL
I
F
---
AFI
CC
A
G
L
FA
L
SA
PLQ
I
L
L
L
QN
A
KG
G
EL
L
GA
A
GGQ
I
AFNLG
S
A
V
GA
YC
GG
M
M
L
T
-
LGL
A
Y
N
Y
V
ALP
A
A
L
LS
FAA
M
S
-
SLL
L
Y
G
R
YKR
Q
fig|595496.3.peg.312
Escherichia coli BW2952 (33-409/422)
IL
S
LALG
T
FG
L
G
MA
EF
G
I
MG
V
L
TE
L
A
HN
V
G
I
SIPAAG
H
MIS
Y
YA
L
GV
V
VGAP
IIA
L
FS
S
RYS
LK
HI
L
L
FL
V
AL
C
VI
GN
AMF
T
LS
S
SY
LM
L
A
I
G
R
L
VSG
F
P
HGAFFG
V
GA
I
V
L
SK
I
I
K
P
GK
V
T
A
AVA
G
M
VS
G
M
T
V
AN
L
LG
I
PLGT
Y
L
S
Q
E
F
S
WR
Y
TFL
L
IA
VFN
I
A
V
M
A
S
V
YFW
V
P
DIRD
EA
K
G
N
L
-
R
EQFHF
LR
S
PA
PW
L
I
F
A
A
T
M
F
G
NA
G
V
F
A
W
F
SY
V
K
P
Y
M
M
F
I
S
G
F
S
ET
A
M
T
F
I
M
M
L
V
G
L
G
MV
L
GN
M
L
S
G
R
I
SG
RY
SPLRIA
A
VTD
F
II
VL
AL
LML
F
--
F
C
G
GM
K
TTSL
I
F
---
AFI
CC
A
G
L
FA
L
SA
PLQ
I
L
L
L
QN
A
KG
G
EL
L
GA
A
GGQ
I
AFNLG
S
A
V
GA
YC
GG
M
M
L
T
-
LGL
A
Y
N
Y
V
ALP
A
A
L
LS
FAA
M
S
-
SLL
L
Y
G
R
YKR
Q
fig|536056.3.peg.3398
Escherichia coli DH1 (33-409/422)
IL
S
LALG
T
FG
L
G
MA
EF
G
I
MG
V
L
TE
L
A
HN
V
G
I
SIPAAG
H
MIS
Y
YA
L
GV
V
VGAP
IIA
L
FS
S
RYS
LK
HI
L
L
FL
V
AL
C
VI
GN
AMF
T
LS
S
SY
LM
L
A
I
G
R
L
VSG
F
P
HGAFFG
V
GA
I
V
L
SK
I
I
K
P
GK
V
T
A
AVA
G
M
VS
G
M
T
V
AN
L
LG
I
PLGT
Y
L
S
Q
E
F
S
WR
Y
TFL
L
IA
VFN
I
A
V
M
A
S
V
YFW
V
P
DIRD
EA
K
G
N
L
-
R
EQFHF
LR
S
PA
PW
L
I
F
A
A
T
M
F
G
NA
G
V
F
A
W
F
SY
V
K
P
Y
M
M
F
I
S
G
F
S
ET
A
M
T
F
I
M
M
L
V
G
L
G
MV
L
GN
M
L
S
G
R
I
SG
RY
SPLRIA
A
VTD
F
II
VL
AL
LML
F
--
F
C
G
GM
K
TTSL
I
F
---
AFI
CC
A
G
L
FA
L
SA
PLQ
I
L
L
L
QN
A
KG
G
EL
L
GA
A
GGQ
I
AFNLG
S
A
V
GA
YC
GG
M
M
L
T
-
LGL
A
Y
N
Y
V
ALP
A
A
L
LS
FAA
M
S
-
SLL
L
Y
G
R
YKR
Q
fig|316401.4.peg.518
Escherichia coli ETEC H10407 (33-409/422)
IL
S
LALG
T
FG
L
G
MA
EF
G
I
MG
V
L
TE
L
A
HN
V
G
I
SIPAAG
H
MIS
Y
YA
L
GV
V
VGAP
IIA
L
FS
S
RYS
LK
HI
L
L
FL
V
AL
C
VI
GN
AMF
T
LS
S
SY
LM
L
A
I
G
R
L
VSG
F
P
HGAFFG
V
GA
I
V
L
SK
I
I
K
P
GK
V
T
A
AVA
G
M
VS
G
M
T
V
AN
L
LG
I
PLGT
Y
L
S
Q
E
F
S
WR
Y
TFL
L
IA
VFN
I
A
V
M
A
S
V
YFW
V
P
DIRD
EA
K
G
N
L
-
R
EQFHF
LR
S
PA
PW
L
I
F
A
A
T
M
F
G
NA
G
V
F
A
W
F
SY
V
K
P
Y
M
M
F
I
S
G
F
S
ET
A
M
T
F
I
M
M
L
V
G
L
G
MV
L
GN
M
L
S
G
R
I
SG
RY
SPLRIA
A
VTD
F
II
VL
AL
LML
F
--
F
C
G
GM
K
TTSL
I
F
---
AFI
CC
A
G
L
FA
L
SA
PLQ
I
L
L
L
QN
A
KG
G
EL
L
GA
A
GGQ
I
AFNLG
S
A
V
GA
YC
GG
M
M
L
T
-
LGL
A
Y
N
Y
V
ALP
A
A
L
LS
FAA
M
S
-
SLL
L
Y
G
R
YKR
Q
fig|656414.3.peg.583
Escherichia coli H736 (33-409/422)
IL
S
LALG
T
FG
L
G
MA
EF
G
I
MG
V
L
TE
L
A
HN
V
G
I
SIPAAG
H
MIS
Y
YA
L
GV
V
VGAP
IIA
L
FS
S
RYS
LK
HI
L
L
FL
V
AL
C
VI
GN
AMF
T
LS
S
SY
LM
L
A
I
G
R
L
VSG
F
P
HGAFFG
V
GA
I
V
L
SK
I
I
K
P
GK
V
T
A
AVA
G
M
VS
G
M
T
V
AN
L
LG
I
PLGT
Y
L
S
Q
E
F
S
WR
Y
TFL
L
IA
VFN
I
A
V
M
A
S
V
YFW
V
P
DIRD
EA
K
G
N
L
-
R
EQFHF
LR
S
PA
PW
L
I
F
A
A
T
M
F
G
NA
G
V
F
A
W
F
SY
V
K
P
Y
M
M
F
I
S
G
F
S
ET
A
M
T
F
I
M
M
L
V
G
L
G
MV
L
GN
M
L
S
G
R
I
SG
RY
SPLRIA
A
VTD
F
II
VL
AL
LML
F
--
F
C
G
GM
K
TTSL
I
F
---
AFI
CC
A
G
L
FA
L
SA
PLQ
I
L
L
L
QN
A
KG
G
EL
L
GA
A
GGQ
I
AFNLG
S
A
V
GA
YC
GG
M
M
L
T
-
LGL
A
Y
N
Y
V
ALP
A
A
L
LS
FAA
M
S
-
SLL
L
Y
G
R
YKR
Q
fig|83333.1.peg.393
Escherichia coli K12 (33-409/422)
IL
S
LALG
T
FG
L
G
MA
EF
G
I
MG
V
L
TE
L
A
HN
V
G
I
SIPAAG
H
MIS
Y
YA
L
GV
V
VGAP
IIA
L
FS
S
RYS
LK
HI
L
L
FL
V
AL
C
VI
GN
AMF
T
LS
S
SY
LM
L
A
I
G
R
L
VSG
F
P
HGAFFG
V
GA
I
V
L
SK
I
I
K
P
GK
V
T
A
AVA
G
M
VS
G
M
T
V
AN
L
LG
I
PLGT
Y
L
S
Q
E
F
S
WR
Y
TFL
L
IA
VFN
I
A
V
M
A
S
V
YFW
V
P
DIRD
EA
K
G
N
L
-
R
EQFHF
LR
S
PA
PW
L
I
F
A
A
T
M
F
G
NA
G
V
F
A
W
F
SY
V
K
P
Y
M
M
F
I
S
G
F
S
ET
A
M
T
F
I
M
M
L
V
G
L
G
MV
L
GN
M
L
S
G
R
I
SG
RY
SPLRIA
A
VTD
F
II
VL
AL
LML
F
--
F
C
G
GM
K
TTSL
I
F
---
AFI
CC
A
G
L
FA
L
SA
PLQ
I
L
L
L
QN
A
KG
G
EL
L
GA
A
GGQ
I
AFNLG
S
A
V
GA
YC
GG
M
M
L
T
-
LGL
A
Y
N
Y
V
ALP
A
A
L
LS
FAA
M
S
-
SLL
L
Y
G
R
YKR
Q
fig|749538.3.peg.1447
Escherichia coli MS 116-1 (33-409/422)
IL
S
LALG
T
FG
L
G
MA
EF
G
I
MG
V
L
TE
L
A
HN
V
G
I
SIPAAG
H
MIS
Y
YA
L
GV
V
VGAP
IIA
L
FS
S
RYS
LK
HI
L
L
FL
V
AL
C
VI
GN
AMF
T
LS
S
SY
LM
L
A
I
G
R
L
VSG
F
P
HGAFFG
V
GA
I
V
L
SK
I
I
K
P
GK
V
T
A
AVA
G
M
VS
G
M
T
V
AN
L
LG
I
PLGT
Y
L
S
Q
E
F
S
WR
Y
TFL
L
IA
VFN
I
A
V
M
A
S
V
YFW
V
P
DIRD
EA
K
G
N
L
-
R
EQFHF
LR
S
PA
PW
L
I
F
A
A
T
M
F
G
NA
G
V
F
A
W
F
SY
V
K
P
Y
M
M
F
I
S
G
F
S
ET
A
M
T
F
I
M
M
L
V
G
L
G
MV
L
GN
M
L
S
G
R
I
SG
RY
SPLRIA
A
VTD
F
II
VL
AL
LML
F
--
F
C
G
GM
K
TTSL
I
F
---
AFI
CC
A
G
L
FA
L
SA
PLQ
I
L
L
L
QN
A
KG
G
EL
L
GA
A
GGQ
I
AFNLG
S
A
V
GA
YC
GG
M
M
L
T
-
LGL
A
Y
N
Y
V
ALP
A
A
L
LS
FAA
M
S
-
SLL
L
Y
G
R
YKR
Q
fig|749540.3.peg.3708
Escherichia coli MS 146-1 (33-409/422)
IL
S
LALG
T
FG
L
G
MA
EF
G
I
MG
V
L
TE
L
A
HN
V
G
I
SIPAAG
H
MIS
Y
YA
L
GV
V
VGAP
IIA
L
FS
S
RYS
LK
HI
L
L
FL
V
AL
C
VI
GN
AMF
T
LS
S
SY
LM
L
A
I
G
R
L
VSG
F
P
HGAFFG
V
GA
I
V
L
SK
I
I
K
P
GK
V
T
A
AVA
G
M
VS
G
M
T
V
AN
L
LG
I
PLGT
Y
L
S
Q
E
F
S
WR
Y
TFL
L
IA
VFN
I
A
V
M
A
S
V
YFW
V
P
DIRD
EA
K
G
N
L
-
R
EQFHF
LR
S
PA
PW
L
I
F
A
A
T
M
F
G
NA
G
V
F
A
W
F
SY
V
K
P
Y
M
M
F
I
S
G
F
S
ET
A
M
T
F
I
M
M
L
V
G
L
G
MV
L
GN
M
L
S
G
R
I
SG
RY
SPLRIA
A
VTD
F
II
VL
AL
LML
F
--
F
C
G
GM
K
TTSL
I
F
---
AFI
CC
A
G
L
FA
L
SA
PLQ
I
L
L
L
QN
A
KG
G
EL
L
GA
A
GGQ
I
AFNLG
S
A
V
GA
YC
GG
M
M
L
T
-
LGL
A
Y
N
Y
V
ALP
A
A
L
LS
FAA
M
S
-
SLL
L
Y
G
R
YKR
Q
fig|316385.5.peg.344
Escherichia coli str. K-12 substr. DH10B (33-409/422)
IL
S
LALG
T
FG
L
G
MA
EF
G
I
MG
V
L
TE
L
A
HN
V
G
I
SIPAAG
H
MIS
Y
YA
L
GV
V
VGAP
IIA
L
FS
S
RYS
LK
HI
L
L
FL
V
AL
C
VI
GN
AMF
T
LS
S
SY
LM
L
A
I
G
R
L
VSG
F
P
HGAFFG
V
GA
I
V
L
SK
I
I
K
P
GK
V
T
A
AVA
G
M
VS
G
M
T
V
AN
L
LG
I
PLGT
Y
L
S
Q
E
F
S
WR
Y
TFL
L
IA
VFN
I
A
V
M
A
S
V
YFW
V
P
DIRD
EA
K
G
N
L
-
R
EQFHF
LR
S
PA
PW
L
I
F
A
A
T
M
F
G
NA
G
V
F
A
W
F
SY
V
K
P
Y
M
M
F
I
S
G
F
S
ET
A
M
T
F
I
M
M
L
V
G
L
G
MV
L
GN
M
L
S
G
R
I
SG
RY
SPLRIA
A
VTD
F
II
VL
AL
LML
F
--
F
C
G
GM
K
TTSL
I
F
---
AFI
CC
A
G
L
FA
L
SA
PLQ
I
L
L
L
QN
A
KG
G
EL
L
GA
A
GGQ
I
AFNLG
S
A
V
GA
YC
GG
M
M
L
T
-
LGL
A
Y
N
Y
V
ALP
A
A
L
LS
FAA
M
S
-
SLL
L
Y
G
R
YKR
Q
fig|316385.7.peg.352
Escherichia coli str. K-12 substr. DH10B (33-409/422)
IL
S
LALG
T
FG
L
G
MA
EF
G
I
MG
V
L
TE
L
A
HN
V
G
I
SIPAAG
H
MIS
Y
YA
L
GV
V
VGAP
IIA
L
FS
S
RYS
LK
HI
L
L
FL
V
AL
C
VI
GN
AMF
T
LS
S
SY
LM
L
A
I
G
R
L
VSG
F
P
HGAFFG
V
GA
I
V
L
SK
I
I
K
P
GK
V
T
A
AVA
G
M
VS
G
M
T
V
AN
L
LG
I
PLGT
Y
L
S
Q
E
F
S
WR
Y
TFL
L
IA
VFN
I
A
V
M
A
S
V
YFW
V
P
DIRD
EA
K
G
N
L
-
R
EQFHF
LR
S
PA
PW
L
I
F
A
A
T
M
F
G
NA
G
V
F
A
W
F
SY
V
K
P
Y
M
M
F
I
S
G
F
S
ET
A
M
T
F
I
M
M
L
V
G
L
G
MV
L
GN
M
L
S
G
R
I
SG
RY
SPLRIA
A
VTD
F
II
VL
AL
LML
F
--
F
C
G
GM
K
TTSL
I
F
---
AFI
CC
A
G
L
FA
L
SA
PLQ
I
L
L
L
QN
A
KG
G
EL
L
GA
A
GGQ
I
AFNLG
S
A
V
GA
YC
GG
M
M
L
T
-
LGL
A
Y
N
Y
V
ALP
A
A
L
LS
FAA
M
S
-
SLL
L
Y
G
R
YKR
Q
fig|511145.12.peg.409
Escherichia coli str. K-12 substr. MG1655 (33-409/422)
IL
S
LALG
T
FG
L
G
MA
EF
G
I
MG
V
L
TE
L
A
HN
V
G
I
SIPAAG
H
MIS
Y
YA
L
GV
V
VGAP
IIA
L
FS
S
RYS
LK
HI
L
L
FL
V
AL
C
VI
GN
AMF
T
LS
S
SY
LM
L
A
I
G
R
L
VSG
F
P
HGAFFG
V
GA
I
V
L
SK
I
I
K
P
GK
V
T
A
AVA
G
M
VS
G
M
T
V
AN
L
LG
I
PLGT
Y
L
S
Q
E
F
S
WR
Y
TFL
L
IA
VFN
I
A
V
M
A
S
V
YFW
V
P
DIRD
EA
K
G
N
L
-
R
EQFHF
LR
S
PA
PW
L
I
F
A
A
T
M
F
G
NA
G
V
F
A
W
F
SY
V
K
P
Y
M
M
F
I
S
G
F
S
ET
A
M
T
F
I
M
M
L
V
G
L
G
MV
L
GN
M
L
S
G
R
I
SG
RY
SPLRIA
A
VTD
F
II
VL
AL
LML
F
--
F
C
G
GM
K
TTSL
I
F
---
AFI
CC
A
G
L
FA
L
SA
PLQ
I
L
L
L
QN
A
KG
G
EL
L
GA
A
GGQ
I
AFNLG
S
A
V
GA
YC
GG
M
M
L
T
-
LGL
A
Y
N
Y
V
ALP
A
A
L
LS
FAA
M
S
-
SLL
L
Y
G
R
YKR
Q
fig|511145.6.peg.404
Escherichia coli str. K-12 substr. MG1655 (33-409/422)
IL
S
LALG
T
FG
L
G
MA
EF
G
I
MG
V
L
TE
L
A
HN
V
G
I
SIPAAG
H
MIS
Y
YA
L
GV
V
VGAP
IIA
L
FS
S
RYS
LK
HI
L
L
FL
V
AL
C
VI
GN
AMF
T
LS
S
SY
LM
L
A
I
G
R
L
VSG
F
P
HGAFFG
V
GA
I
V
L
SK
I
I
K
P
GK
V
T
A
AVA
G
M
VS
G
M
T
V
AN
L
LG
I
PLGT
Y
L
S
Q
E
F
S
WR
Y
TFL
L
IA
VFN
I
A
V
M
A
S
V
YFW
V
P
DIRD
EA
K
G
N
L
-
R
EQFHF
LR
S
PA
PW
L
I
F
A
A
T
M
F
G
NA
G
V
F
A
W
F
SY
V
K
P
Y
M
M
F
I
S
G
F
S
ET
A
M
T
F
I
M
M
L
V
G
L
G
MV
L
GN
M
L
S
G
R
I
SG
RY
SPLRIA
A
VTD
F
II
VL
AL
LML
F
--
F
C
G
GM
K
TTSL
I
F
---
AFI
CC
A
G
L
FA
L
SA
PLQ
I
L
L
L
QN
A
KG
G
EL
L
GA
A
GGQ
I
AFNLG
S
A
V
GA
YC
GG
M
M
L
T
-
LGL
A
Y
N
Y
V
ALP
A
A
L
LS
FAA
M
S
-
SLL
L
Y
G
R
YKR
Q
fig|344610.7.peg.1282
Escherichia coli 53638 (33-409/422)
IL
S
LALG
T
FG
L
G
MA
EF
G
I
MG
V
L
TE
L
A
HN
V
G
I
SIPAAG
H
MIS
Y
YA
L
GV
V
VGAP
IIA
L
FS
S
RYS
LK
HI
L
L
FL
V
AL
C
VI
GN
AMF
T
LS
S
SY
LM
L
A
I
G
R
L
VSG
F
P
HGAFFG
V
GA
I
V
L
SK
I
I
K
P
GK
V
T
A
AVA
G
M
VS
G
M
T
V
AN
L
LG
I
PLGT
Y
L
S
Q
E
F
S
WR
Y
TFL
L
IA
VFN
I
A
V
M
A
S
V
YFW
V
P
DIRD
EA
K
G
N
L
-
R
EQFHF
LR
S
PA
PW
L
I
F
A
A
T
M
F
G
NA
G
V
F
A
W
F
SY
V
K
P
Y
M
M
F
I
S
G
F
S
ET
A
M
T
F
I
M
M
L
V
G
L
G
MV
L
GN
M
L
S
G
R
I
SG
RY
SPLRIA
A
VTD
F
II
VL
AL
LML
F
--
F
C
G
GM
K
TTSL
I
F
---
AFI
CC
A
G
L
FA
L
SA
PLQ
I
L
L
L
QN
A
KG
G
EL
L
GA
A
GGQ
I
AFNLG
S
A
V
GA
YC
GG
M
M
L
T
-
LGL
A
Y
N
Y
V
ALP
A
A
L
LS
FAA
M
S
-
SLL
L
Y
G
R
YKR
Q
fig|749531.3.peg.4180
Escherichia coli MS 69-1 (33-409/422)
IL
S
LALG
T
FG
L
G
MA
EF
G
I
MG
V
L
TE
L
A
HN
V
G
I
SIPAAG
H
MIS
Y
YA
L
GV
V
VGAP
IIA
L
FS
S
RYS
LK
HI
L
L
FL
V
AL
C
VI
GN
AMF
T
LS
S
SY
LM
L
A
I
G
R
L
VSG
F
P
HGAFFG
V
GA
I
V
L
SK
I
I
K
P
GK
V
T
A
AVA
G
M
VS
G
M
T
V
AN
L
LG
I
PLGT
Y
L
S
Q
E
F
S
WR
Y
TFL
L
IA
VFN
I
A
V
M
A
S
V
YFW
V
P
DIRD
EA
K
G
K
L
-
R
EQFHF
LR
S
PA
PW
L
I
F
A
A
T
M
F
G
NA
G
V
F
A
W
F
SY
V
K
P
Y
M
M
F
I
S
G
F
S
ET
A
M
T
F
I
M
M
L
V
G
L
G
MV
L
GN
V
L
S
G
R
I
SG
RY
SPLRIA
A
VTD
F
II
VL
AL
LML
F
--
F
F
G
GM
K
TTSL
I
F
---
AFF
CC
A
G
L
FA
L
SA
PLQ
I
L
L
L
QN
A
KG
G
EL
L
GA
A
GGQ
I
AFNLG
S
A
V
GA
YC
GG
M
M
L
T
-
LGL
A
Y
N
Y
V
ALP
A
A
L
LS
FAA
M
S
-
SLL
L
Y
G
R
YKR
Q
fig|749547.3.peg.2520
Escherichia coli MS 187-1 (33-409/422)
IL
S
LALG
T
FG
L
G
MA
EF
G
I
MG
V
L
TE
L
A
HN
V
G
I
SIPAAG
H
MIS
Y
YA
L
GV
V
VGAP
IIA
L
FS
S
RYS
LK
HI
L
L
FL
V
AL
C
VI
GN
AMF
T
LS
S
SY
LM
L
A
I
G
R
L
VSG
F
P
HGAFFG
V
GA
I
V
L
SK
I
I
K
P
GK
V
T
A
AVA
G
V
GS
G
M
T
V
AN
L
LG
I
PLGT
Y
L
S
Q
E
F
S
WR
Y
TFL
L
IA
VFN
I
A
V
M
A
S
V
YFW
V
P
DICD
EA
K
G
N
L
-
R
EQFHF
LR
S
PA
PW
L
I
F
A
A
T
M
F
G
NA
G
V
F
A
W
F
SY
V
K
P
Y
M
M
F
I
S
G
F
S
ET
A
M
T
F
I
M
M
L
V
G
L
G
MV
L
GN
M
L
S
G
R
I
SG
RY
SPLRIA
A
VTD
F
II
VL
AL
LML
F
--
F
C
G
GM
K
TTSL
I
F
---
AFI
CC
A
G
L
FA
L
SA
PLQ
I
L
L
L
QN
A
KG
G
EL
L
GA
A
GGQ
I
AFNLG
S
A
V
GA
YC
GG
M
M
L
T
-
LGL
A
Y
N
Y
V
ALP
A
A
L
LS
FAA
M
S
-
SLL
L
Y
G
R
YKR
Q
fig|749527.3.peg.1301
Escherichia coli MS 21-1 (33-409/422)
IL
S
LALG
T
FG
L
G
MA
EF
G
I
MG
V
L
TE
L
A
HN
V
G
I
SIPAAG
H
MIS
Y
YA
L
GV
V
VGAP
IIA
L
FS
S
RYS
LK
HI
L
L
FL
V
AL
C
VI
GN
AMF
T
LS
S
SY
LM
L
A
I
G
R
L
VSG
F
P
HGAFFG
V
GA
I
V
L
SK
I
I
K
P
GK
V
T
A
AVA
G
M
VS
G
M
T
V
AN
L
LG
I
PLGT
Y
L
S
Q
E
F
S
WR
Y
TFL
L
IA
VFN
I
A
V
M
A
S
V
YFW
V
P
DIRD
EA
K
G
K
L
-
R
EQFHF
LR
S
PA
PW
L
I
F
A
A
T
M
F
G
NA
G
V
F
A
W
F
SY
V
K
P
Y
M
M
F
I
S
G
F
S
ET
A
M
T
F
I
M
M
L
V
G
L
G
MV
L
GN
V
L
S
G
R
I
SG
RY
SPLRIA
A
VTD
F
II
VL
AL
LML
F
--
F
F
G
GM
K
ITSL
I
F
---
AFI
CC
A
G
L
FA
L
SA
H
LQ
I
L
L
L
QN
A
KG
G
EL
L
GA
A
GGQ
I
AFNLG
S
A
V
GA
YC
GG
M
M
L
T
-
LG
M
A
Y
N
Y
V
ALP
A
A
L
LS
FAA
M
S
-
SLL
L
Y
G
R
YKR
Q
fig|1040638.4.peg.5079
Escherichia coli O104:H4 str. LB226692 (3-365/378)
EF
G
I
MG
V
L
TE
L
A
HN
V
G
I
SIPAAG
H
MIS
Y
YA
L
GV
V
VGAP
IIA
L
FS
S
RYS
LK
HI
L
L
FL
V
AL
C
VI
GN
AMF
T
LS
S
SY
LM
L
A
I
G
R
L
VSG
F
P
HGAFFG
V
GA
I
V
L
SK
I
I
K
P
GK
V
T
A
AVA
G
M
VS
G
M
T
V
AN
L
LG
I
PLGT
Y
L
S
Q
E
F
S
WR
Y
TFL
L
IA
VFN
I
A
V
M
A
S
V
YFW
V
P
DIRD
EA
K
G
K
L
-
R
EQFHF
LR
S
PA
PW
L
I
F
A
A
T
M
F
G
NA
G
V
F
A
W
F
SY
V
K
P
Y
M
M
F
I
S
G
F
S
ET
A
M
T
F
I
M
M
L
V
G
L
G
MV
L
GN
M
L
S
G
R
I
SG
RY
SPLRIA
A
VTD
F
II
VL
AL
LML
F
--
F
C
G
GM
K
TTSL
I
F
---
AFI
CC
A
G
L
FA
L
SA
PLQ
I
L
L
L
QN
A
KG
G
EL
L
GA
A
GGQ
I
AFNLG
S
A
V
GA
YC
GG
M
M
L
T
-
LGL
A
Y
N
Y
V
ALP
A
A
L
LS
FAA
M
S
-
SLL
L
Y
G
R
YKR
Q
fig|444454.5.peg.710
Escherichia coli O157:H7 str. EC4024 (18-385/406)
L
FI
LA
I
S
T
F
T
I
V
TTE
L
A
P
V
GLL
TP
IA
EG
L
Q
S
S
ES
A
V
G
M
T
V
S
L
YA
W
V
G
A
L
S
A
L
FAS
V
FL
G
NVA
K
R
RL
L
L
V
L
T
V
V
L
LV
S
NV
M
A
A
TV
H
T
Y
SM
L
L
S
A
R
V
LGA
L
A
HGAF
W
A
M
IG
A
T
A
VA
M
V
P
A
RY
I
G
A
A
T
S
I
V
FG
G
V
S
A
A
S
V
F
GVP
V
SN
Y
I
G
I
H
FGWR
QA
F
W
L
M
A
ALS
VI
A
F
V
G
I
SVL
V
P
QITS
R
S
A
L
G
L
-
D
ALKGV
L
K
S
ST
LW
K
I
Y
S
A
T
L
L
A
VT
A
H
F
A
A
FT
YI
E
P
W
L
H
T
Q
S
L
L
S
TA
I
I
P
A
V
L
F
V
Y
G
I
A
GL
A
GN
F
L
T
G
V
L
ID
K
Y
LKLTVS
-
-LS
V
LL
I
C
AV
L
L
F
L
--
G
L
S
GS
S
LSAA
L
I
FTS
MVV
WG
V
A
V
SG
I
FV
G
F
Q
T
W
VL
RM
A
ED
K
AF
P
AS
A
IYV
SF
FN
TA
I
G
I
GA
SV
G
A
W
M
-
V
-
SAF
S
M
P
L
L
YIV
---
-A
G
S
A
I
G
L
S
V
L
L
V
fig|562.376.peg.2990
Escherichia coli WV_060327 (15-391/396)
V
V
T
LA
V
A
AF
I
F
N
TTEF
V
P
V
GLL
SD
IA
HS
F
H
M
QTAQV
G
I
M
LT
I
YA
W
V
V
A
LMSL
PFM
L
MT
S
QVE
RR
KL
LI
C
L
F
V
V
F
IA
SH
VLS
F
LS
W
S
F
TV
L
V
ISRI
GVA
F
A
H
AI
F
WS
I
T
A
S
L
A
IR
M
A
P
A
GK
R
A
Q
A
LS
L
I
AT
G
T
A
LA
M
VLG
L
PLG
R
I
V
GQ
Y
FGWRMTF
F
AI
G
IGA
L
I
T
L
L
C
L
IKL
LP
LLPS
E
H
S
G
S
L
-
K
SLPLL
F
RRPA
LM
SI
Y
L
L
TV
V
V
VT
A
H
Y
T
A
YSYI
E
P
F
V
Q
N
I
A
G
F
S
AN
F
A
TA
L
LLL
L
G
S
A
GI
IG
S
V
I
F
GKL
GN
Q
Y
ASALVS
T
AIA
L
LLV
C
LA
L
L
-
L
--
P
A
A
NS
E
IHLG
V
L
---
SIF
WG
I
A
M
MI
I
GL
GM
Q
V
K
VL
AL
A
PD
A
TD
V
AM
A
LFS
G
I
FN
I
G
I
G
A
GA
LV
G
N
Q
V
-
S
-
L
HW
S
M
S
M
I
GYV
GA
V
PA
FAAL
I
W
S
II
I
F
R
R
WPV
TL
fig|344601.3.peg.302
Escherichia coli B171 (15-391/396)
V
V
T
LA
V
A
AF
I
F
N
TTEF
V
P
V
GLL
SD
IA
QS
F
H
M
QTAQV
G
I
M
LT
I
YA
W
V
V
A
LMSL
PFM
L
MT
S
QVE
RR
KL
LI
C
L
F
V
V
F
IA
SH
VLS
F
LS
W
S
F
TV
L
V
ISRI
GVA
F
A
H
AI
F
WS
I
T
A
S
L
A
IR
M
A
P
A
GK
R
A
Q
A
LS
L
I
AT
G
T
A
LA
M
VLG
L
PLG
R
I
V
GQ
Y
FGWRMTF
F
AI
G
IGA
L
I
T
L
L
C
L
IKL
LP
LLPS
E
H
S
G
S
L
-
K
SLPLL
F
RRPA
LM
SI
Y
L
L
TV
V
V
VT
A
H
Y
T
A
YSYI
E
P
F
V
Q
N
I
A
G
F
S
AN
F
A
TA
L
LLL
L
G
G
S
GI
IG
S
V
I
F
GKL
GN
Q
Y
ASALVS
T
AIA
L
LLV
C
LA
L
L
-
L
--
P
A
A
NS
E
IHLG
V
L
---
SIF
WG
I
A
M
MI
I
GL
GM
Q
V
K
VL
AL
A
PD
A
TD
V
AM
A
LFS
G
I
FN
I
G
I
G
A
GA
LV
G
N
Q
V
-
S
-
L
HW
S
M
S
M
I
GYV
GA
V
PA
FAAL
I
W
S
II
I
F
R
R
WPV
TL
fig|344601.5.peg.299
Escherichia coli B171 (15-391/396)
V
V
T
LA
V
A
AF
I
F
N
TTEF
V
P
V
GLL
SD
IA
QS
F
H
M
QTAQV
G
I
M
LT
I
YA
W
V
V
A
LMSL
PFM
L
MT
S
QVE
RR
KL
LI
C
L
F
V
V
F
IA
SH
VLS
F
LS
W
S
F
TV
L
V
ISRI
GVA
F
A
H
AI
F
WS
I
T
A
S
L
A
IR
M
A
P
A
GK
R
A
Q
A
LS
L
I
AT
G
T
A
LA
M
VLG
L
PLG
R
I
V
GQ
Y
FGWRMTF
F
AI
G
IGA
L
I
T
L
L
C
L
IKL
LP
LLPS
E
H
S
G
S
L
-
K
SLPLL
F
RRPA
LM
SI
Y
L
L
TV
V
V
VT
A
H
Y
T
A
YSYI
E
P
F
V
Q
N
I
A
G
F
S
AN
F
A
TA
L
LLL
L
G
G
S
GI
IG
S
V
I
F
GKL
GN
Q
Y
ASALVS
T
AIA
L
LLV
C
LA
L
L
-
L
--
P
A
A
NS
E
IHLG
V
L
---
SIF
WG
I
A
M
MI
I
GL
GM
Q
V
K
VL
AL
A
PD
A
TD
V
AM
A
LFS
G
I
FN
I
G
I
G
A
GA
LV
G
N
Q
V
-
S
-
L
HW
S
M
S
M
I
GYV
GA
V
PA
FAAL
I
W
S
II
I
F
R
R
WPV
TL
fig|340185.3.peg.2653
Escherichia coli E22 (15-391/396)
V
V
T
LA
V
A
AF
I
F
N
TTEF
V
P
V
GLL
SD
IA
QS
F
H
M
QTAQV
G
I
M
LT
I
YA
W
V
V
A
LMSL
PFM
L
MT
S
QVE
RR
KL
LI
C
L
F
V
V
F
IA
SH
VLS
F
LS
W
S
F
TV
L
V
ISRI
GVA
F
A
H
AI
F
WS
I
T
A
S
L
A
IR
M
A
P
A
GK
R
A
Q
A
LS
L
I
AT
G
T
A
LA
M
VLG
L
PLG
R
I
V
GQ
Y
FGWRMTF
F
AI
G
IGA
L
I
T
L
L
C
L
IKL
LP
LLPS
E
H
S
G
S
L
-
K
SLPLL
F
RRPA
LM
SI
Y
L
L
TV
V
V
VT
A
H
Y
T
A
YSYI
E
P
F
V
Q
N
I
A
G
F
S
AN
F
A
TA
L
LLL
L
G
G
S
GI
IG
S
V
I
F
GKL
GN
Q
Y
ASALVS
T
AIA
L
LLV
C
LA
L
L
-
L
--
P
A
A
NS
E
IHLG
V
L
---
SIF
WG
I
A
M
MI
I
GL
GM
Q
V
K
VL
AL
A
PD
A
TD
V
AM
A
LFS
G
I
FN
I
G
I
G
A
GA
LV
G
N
Q
V
-
S
-
L
HW
S
M
S
M
I
GYV
GA
V
PA
FAAL
I
W
S
II
I
F
R
R
WPV
TL
fig|340185.4.peg.2797
Escherichia coli E22 (15-391/396)
V
V
T
LA
V
A
AF
I
F
N
TTEF
V
P
V
GLL
SD
IA
QS
F
H
M
QTAQV
G
I
M
LT
I
YA
W
V
V
A
LMSL
PFM
L
MT
S
QVE
RR
KL
LI
C
L
F
V
V
F
IA
SH
VLS
F
LS
W
S
F
TV
L
V
ISRI
GVA
F
A
H
AI
F
WS
I
T
A
S
L
A
IR
M
A
P
A
GK
R
A
Q
A
LS
L
I
AT
G
T
A
LA
M
VLG
L
PLG
R
I
V
GQ
Y
FGWRMTF
F
AI
G
IGA
L
I
T
L
L
C
L
IKL
LP
LLPS
E
H
S
G
S
L
-
K
SLPLL
F
RRPA
LM
SI
Y
L
L
TV
V
V
VT
A
H
Y
T
A
YSYI
E
P
F
V
Q
N
I
A
G
F
S
AN
F
A
TA
L
LLL
L
G
G
S
GI
IG
S
V
I
F
GKL
GN
Q
Y
ASALVS
T
AIA
L
LLV
C
LA
L
L
-
L
--
P
A
A
NS
E
IHLG
V
L
---
SIF
WG
I
A
M
MI
I
GL
GM
Q
V
K
VL
AL
A
PD
A
TD
V
AM
A
LFS
G
I
FN
I
G
I
G
A
GA
LV
G
N
Q
V
-
S
-
L
HW
S
M
S
M
I
GYV
GA
V
PA
FAAL
I
W
S
II
I
F
R
R
WPV
TL
fig|585395.4.peg.1738
Escherichia coli O103:H2 str. 12009 (15-391/396)
V
V
T
LA
V
A
AF
I
F
N
TTEF
V
P
V
GLL
SD
IA
QS
F
H
M
QTAQV
G
I
M
LT
I
YA
W
V
V
A
LMSL
PFM
L
MT
S
QVE
RR
KL
LI
C
L
F
V
V
F
IA
SH
VLS
F
LS
W
S
F
TV
L
V
ISRI
GVA
F
A
H
AI
F
WS
I
T
A
S
L
A
IR
M
A
P
A
GK
R
A
Q
A
LS
L
I
AT
G
T
A
LA
M
VLG
L
PLG
R
I
V
GQ
Y
FGWRMTF
F
AI
G
IGA
L
I
T
L
L
C
L
IKL
LP
LLPS
E
H
S
G
S
L
-
K
SLPLL
F
RRPA
LM
SI
Y
L
L
TV
V
V
VT
A
H
Y
T
A
YSYI
E
P
F
V
Q
N
I
A
G
F
S
AN
F
A
TA
L
LLL
L
G
G
S
GI
IG
S
V
I
F
GKL
GN
Q
Y
ASALVS
T
AIA
L
LLV
C
LA
L
L
-
L
--
P
A
A
NS
E
IHLG
V
L
---
SIF
WG
I
A
M
MI
I
GL
GM
Q
V
K
VL
AL
A
PD
A
TD
V
AM
A
LFS
G
I
FN
I
G
I
G
A
GA
LV
G
N
Q
V
-
S
-
L
HW
S
M
S
M
I
GYV
GA
V
PA
FAAL
I
W
S
II
I
F
R
R
WPV
TL
fig|679206.4.peg.3287
Escherichia coli MS 119-7 (15-391/396)
V
V
T
LA
V
A
AF
I
F
N
TTEF
V
P
V
GLL
SD
IA
QS
F
H
M
QTAQV
G
I
M
LT
I
YA
W
V
V
A
LMSL
PFM
L
MT
S
QVE
RR
KL
LI
C
L
F
V
V
F
IA
SH
VLS
F
LS
W
S
F
TV
L
V
ISRI
GVA
F
A
H
AI
F
WS
I
T
A
S
L
A
IR
M
A
P
A
GK
R
A
Q
A
LS
L
I
AT
G
T
A
LA
M
VLG
L
PLG
R
I
V
GQ
Y
FGWRMTF
F
AI
G
IAA
L
I
T
L
L
C
L
IKL
LP
LLPS
E
H
S
G
S
L
-
K
SLPLL
F
RRPA
LM
SI
Y
L
L
TV
V
V
VT
A
H
Y
T
A
YSYI
E
P
F
V
Q
N
I
A
G
F
S
AN
F
A
TA
L
LLL
L
G
G
A
GI
IG
S
V
I
F
GKL
GN
Q
Y
ASALVS
T
AIA
L
LLV
C
LA
L
L
-
L
--
P
A
A
NS
E
IHLG
V
L
---
SIF
WG
I
A
M
MI
I
GL
GM
Q
V
K
VL
AL
A
PD
A
TD
V
AM
A
LFS
G
I
FN
I
G
I
G
A
GA
LV
G
N
Q
V
-
S
-
L
HW
S
M
S
M
I
GYV
GA
V
PA
FAAL
I
W
S
II
I
F
R
R
WPV
TL
fig|656443.3.peg.1883
Escherichia coli TA271 (15-391/396)
V
V
T
LA
V
A
AF
I
F
N
TTEF
V
P
V
GLL
SD
IA
QS
F
H
M
QTAQV
G
I
M
LT
I
YA
W
V
V
A
LMSL
PFM
L
MT
S
QVE
RR
KL
LI
C
L
F
V
V
F
IA
SH
VLS
F
LS
W
S
F
TV
L
V
ISRI
GVA
F
A
H
AI
F
WS
I
T
A
S
L
A
IR
M
A
P
A
GK
R
A
Q
A
LS
L
I
AT
G
T
A
LA
M
VLG
L
PLG
R
I
V
GQ
Y
FGWRMTF
F
AI
G
IAA
L
I
T
L
L
C
L
IKL
LP
LLPS
E
H
S
G
S
L
-
K
SLPLL
F
RRPA
LM
SI
Y
L
L
TV
V
V
VT
A
H
Y
T
A
YSYI
E
P
F
V
Q
N
I
A
G
F
S
AN
F
A
TA
L
LLL
L
G
G
A
GI
IG
S
V
I
F
GKL
GN
Q
Y
ASALVS
T
AIA
L
LLV
C
LA
L
L
-
L
--
P
A
A
NS
E
IHLG
V
L
---
SIF
WG
I
A
M
MI
I
GL
GM
Q
V
K
VL
AL
A
PD
A
TD
V
AM
A
LFS
G
I
FN
I
G
I
G
A
GA
LV
G
N
Q
V
-
S
-
L
HW
S
M
S
M
I
GYV
GA
V
PA
FAAL
I
W
S
II
I
F
R
R
WPV
TL
fig|562.373.peg.5017
Escherichia coli 1125A (15-391/396)
V
V
T
LA
V
A
AF
I
F
N
TTEF
V
P
V
GLL
SD
IA
QS
F
H
M
QTAQV
G
I
M
LT
I
YA
W
V
V
A
LMSL
PFM
L
MT
S
QVE
RR
KL
LI
C
L
F
V
V
F
IA
SH
VLS
F
LS
W
S
F
TV
L
V
ISRI
GVA
F
A
H
AI
F
WS
I
T
A
S
L
A
IR
M
A
P
A
GK
R
A
Q
A
LS
L
I
AT
G
T
A
LA
M
VLG
L
PLG
R
I
V
GQ
Y
FGWRMTF
F
AI
G
IGA
L
I
T
L
L
C
L
IKL
LP
LLPS
E
H
S
G
S
L
-
K
SLPLL
F
RRPA
LM
SI
Y
L
L
TV
V
V
VT
A
H
Y
T
A
YSYI
E
P
F
V
Q
N
I
A
G
F
S
AN
F
A
TA
L
LLL
L
G
G
A
GI
IG
S
V
I
F
GKL
GN
Q
Y
ASALVS
T
AIA
L
LLV
C
LA
L
L
-
L
--
P
A
A
NS
E
IHLG
V
L
---
SIF
WG
I
A
M
MI
I
GL
GM
Q
V
K
VL
AL
A
PD
A
TD
V
AM
A
LFS
G
I
FN
I
G
I
G
A
GA
LV
G
N
Q
V
-
S
-
L
H
L
S
M
S
M
I
GYV
G
T
V
PA
FAAL
I
W
S
II
I
F
R
R
WPV
TL
fig|444454.5.peg.1045
Escherichia coli O157:H7 str. EC4024 (15-391/396)
V
V
T
LA
V
A
AF
I
F
N
TTEF
V
P
V
GLL
SD
IA
QS
F
H
M
QTAQV
G
I
M
LT
I
YA
W
V
V
A
LMSL
PFM
L
MT
S
QVE
RR
KL
LI
C
L
F
V
V
F
IA
SH
VLS
F
LS
W
S
F
TV
L
V
ISRI
GVA
F
A
H
AI
F
WS
I
T
A
S
L
A
IR
M
A
P
A
GK
R
A
Q
A
LS
L
I
AT
G
T
A
LA
M
VLG
L
PLG
R
I
V
GQ
Y
FGWRMTF
F
AI
G
IGA
L
I
T
L
L
C
L
IKL
LP
LLPS
E
H
S
G
S
L
-
K
SLPLL
F
RRPA
LM
SI
Y
L
L
TV
V
V
VT
A
H
Y
T
A
YSYI
E
P
F
V
Q
N
I
A
G
F
S
AN
F
A
TA
L
LLL
L
G
G
A
GI
IG
S
V
I
F
GKL
GN
Q
Y
ASALVS
T
AIA
L
LLV
C
LA
L
L
-
L
--
P
A
A
NS
E
IHLG
V
L
---
SIF
WG
I
A
M
MI
I
GL
GM
Q
V
K
VL
AL
A
PD
A
TD
V
AM
A
LFS
G
I
FN
I
G
I
G
A
GA
LV
G
N
Q
V
-
S
-
L
H
L
S
M
S
M
I
GYV
G
T
V
PA
FAAL
I
W
S
II
I
F
R
R
WPV
TL
fig|444449.5.peg.371
Escherichia coli O157:H7 str. EC4042 (15-391/396)
V
V
T
LA
V
A
AF
I
F
N
TTEF
V
P
V
GLL
SD
IA
QS
F
H
M
QTAQV
G
I
M
LT
I
YA
W
V
V
A
LMSL
PFM
L
MT
S
QVE
RR
KL
LI
C
L
F
V
V
F
IA
SH
VLS
F
LS
W
S
F
TV
L
V
ISRI
GVA
F
A
H
AI
F
WS
I
T
A
S
L
A
IR
M
A
P
A
GK
R
A
Q
A
LS
L
I
AT
G
T
A
LA
M
VLG
L
PLG
R
I
V
GQ
Y
FGWRMTF
F
AI
G
IGA
L
I
T
L
L
C
L
IKL
LP
LLPS
E
H
S
G
S
L
-
K
SLPLL
F
RRPA
LM
SI
Y
L
L
TV
V
V
VT
A
H
Y
T
A
YSYI
E
P
F
V
Q
N
I
A
G
F
S
AN
F
A
TA
L
LLL
L
G
G
A
GI
IG
S
V
I
F
GKL
GN
Q
Y
ASALVS
T
AIA
L
LLV
C
LA
L
L
-
L
--
P
A
A
NS
E
IHLG
V
L
---
SIF
WG
I
A
M
MI
I
GL
GM
Q
V
K
VL
AL
A
PD
A
TD
V
AM
A
LFS
G
I
FN
I
G
I
G
A
GA
LV
G
N
Q
V
-
S
-
L
H
L
S
M
S
M
I
GYV
G
T
V
PA
FAAL
I
W
S
II
I
F
R
R
WPV
TL
fig|444448.5.peg.4729
Escherichia coli O157:H7 str. EC4045 (15-391/396)
V
V
T
LA
V
A
AF
I
F
N
TTEF
V
P
V
GLL
SD
IA
QS
F
H
M
QTAQV
G
I
M
LT
I
YA
W
V
V
A
LMSL
PFM
L
MT
S
QVE
RR
KL
LI
C
L
F
V
V
F
IA
SH
VLS
F
LS
W
S
F
TV
L
V
ISRI
GVA
F
A
H
AI
F
WS
I
T
A
S
L
A
IR
M
A
P
A
GK
R
A
Q
A
LS
L
I
AT
G
T
A
LA
M
VLG
L
PLG
R
I
V
GQ
Y
FGWRMTF
F
AI
G
IGA
L
I
T
L
L
C
L
IKL
LP
LLPS
E
H
S
G
S
L
-
K
SLPLL
F
RRPA
LM
SI
Y
L
L
TV
V
V
VT
A
H
Y
T
A
YSYI
E
P
F
V
Q
N
I
A
G
F
S
AN
F
A
TA
L
LLL
L
G
G
A
GI
IG
S
V
I
F
GKL
GN
Q
Y
ASALVS
T
AIA
L
LLV
C
LA
L
L
-
L
--
P
A
A
NS
E
IHLG
V
L
---
SIF
WG
I
A
M
MI
I
GL
GM
Q
V
K
VL
AL
A
PD
A
TD
V
AM
A
LFS
G
I
FN
I
G
I
G
A
GA
LV
G
N
Q
V
-
S
-
L
H
L
S
M
S
M
I
GYV
G
T
V
PA
FAAL
I
W
S
II
I
F
R
R
WPV
TL
fig|444453.5.peg.2925
Escherichia coli O157:H7 str. EC4076 (15-391/396)
V
V
T
LA
V
A
AF
I
F
N
TTEF
V
P
V
GLL
SD
IA
QS
F
H
M
QTAQV
G
I
M
LT
I
YA
W
V
V
A
LMSL
PFM
L
MT
S
QVE
RR
KL
LI
C
L
F
V
V
F
IA
SH
VLS
F
LS
W
S
F
TV
L
V
ISRI
GVA
F
A
H
AI
F
WS
I
T
A
S
L
A
IR
M
A
P
A
GK
R
A
Q
A
LS
L
I
AT
G
T
A
LA
M
VLG
L
PLG
R
I
V
GQ
Y
FGWRMTF
F
AI
G
IGA
L
I
T
L
L
C
L
IKL
LP
LLPS
E
H
S
G
S
L
-
K
SLPLL
F
RRPA
LM
SI
Y
L
L
TV
V
V
VT
A
H
Y
T
A
YSYI
E
P
F
V
Q
N
I
A
G
F
S
AN
F
A
TA
L
LLL
L
G
G
A
GI
IG
S
V
I
F
GKL
GN
Q
Y
ASALVS
T
AIA
L
LLV
C
LA
L
L
-
L
--
P
A
A
NS
E
IHLG
V
L
---
SIF
WG
I
A
M
MI
I
GL
GM
Q
V
K
VL
AL
A
PD
A
TD
V
AM
A
LFS
G
I
FN
I
G
I
G
A
GA
LV
G
N
Q
V
-
S
-
L
H
L
S
M
S
M
I
GYV
G
T
V
PA
FAAL
I
W
S
II
I
F
R
R
WPV
TL
fig|444452.5.peg.1891
Escherichia coli O157:H7 str. EC4113 (15-391/396)
V
V
T
LA
V
A
AF
I
F
N
TTEF
V
P
V
GLL
SD
IA
QS
F
H
M
QTAQV
G
I
M
LT
I
YA
W
V
V
A
LMSL
PFM
L
MT
S
QVE
RR
KL
LI
C
L
F
V
V
F
IA
SH
VLS
F
LS
W
S
F
TV
L
V
ISRI
GVA
F
A
H
AI
F
WS
I
T
A
S
L
A
IR
M
A
P
A
GK
R
A
Q
A
LS
L
I
AT
G
T
A
LA
M
VLG
L
PLG
R
I
V
GQ
Y
FGWRMTF
F
AI
G
IGA
L
I
T
L
L
C
L
IKL
LP
LLPS
E
H
S
G
S
L
-
K
SLPLL
F
RRPA
LM
SI
Y
L
L
TV
V
V
VT
A
H
Y
T
A
YSYI
E
P
F
V
Q
N
I
A
G
F
S
AN
F
A
TA
L
LLL
L
G
G
A
GI
IG
S
V
I
F
GKL
GN
Q
Y
ASALVS
T
AIA
L
LLV
C
LA
L
L
-
L
--
P
A
A
NS
E
IHLG
V
L
---
SIF
WG
I
A
M
MI
I
GL
GM
Q
V
K
VL
AL
A
PD
A
TD
V
AM
A
LFS
G
I
FN
I
G
I
G
A
GA
LV
G
N
Q
V
-
S
-
L
H
L
S
M
S
M
I
GYV
G
T
V
PA
FAAL
I
W
S
II
I
F
R
R
WPV
TL
fig|444450.8.peg.2188
Escherichia coli O157:H7 str. EC4115 (15-391/396)
V
V
T
LA
V
A
AF
I
F
N
TTEF
V
P
V
GLL
SD
IA
QS
F
H
M
QTAQV
G
I
M
LT
I
YA
W
V
V
A
LMSL
PFM
L
MT
S
QVE
RR
KL
LI
C
L
F
V
V
F
IA
SH
VLS
F
LS
W
S
F
TV
L
V
ISRI
GVA
F
A
H
AI
F
WS
I
T
A
S
L
A
IR
M
A
P
A
GK
R
A
Q
A
LS
L
I
AT
G
T
A
LA
M
VLG
L
PLG
R
I
V
GQ
Y
FGWRMTF
F
AI
G
IGA
L
I
T
L
L
C
L
IKL
LP
LLPS
E
H
S
G
S
L
-
K
SLPLL
F
RRPA
LM
SI
Y
L
L
TV
V
V
VT
A
H
Y
T
A
YSYI
E
P
F
V
Q
N
I
A
G
F
S
AN
F
A
TA
L
LLL
L
G
G
A
GI
IG
S
V
I
F
GKL
GN
Q
Y
ASALVS
T
AIA
L
LLV
C
LA
L
L
-
L
--
P
A
A
NS
E
IHLG
V
L
---
SIF
WG
I
A
M
MI
I
GL
GM
Q
V
K
VL
AL
A
PD
A
TD
V
AM
A
LFS
G
I
FN
I
G
I
G
A
GA
LV
G
N
Q
V
-
S
-
L
H
L
S
M
S
M
I
GYV
G
T
V
PA
FAAL
I
W
S
II
I
F
R
R
WPV
TL
fig|444451.5.peg.1884
Escherichia coli O157:H7 str. EC4196 (15-391/396)
V
V
T
LA
V
A
AF
I
F
N
TTEF
V
P
V
GLL
SD
IA
QS
F
H
M
QTAQV
G
I
M
LT
I
YA
W
V
V
A
LMSL
PFM
L
MT
S
QVE
RR
KL
LI
C
L
F
V
V
F
IA
SH
VLS
F
LS
W
S
F
TV
L
V
ISRI
GVA
F
A
H
AI
F
WS
I
T
A
S
L
A
IR
M
A
P
A
GK
R
A
Q
A
LS
L
I
AT
G
T
A
LA
M
VLG
L
PLG
R
I
V
GQ
Y
FGWRMTF
F
AI
G
IGA
L
I
T
L
L
C
L
IKL
LP
LLPS
E
H
S
G
S
L
-
K
SLPLL
F
RRPA
LM
SI
Y
L
L
TV
V
V
VT
A
H
Y
T
A
YSYI
E
P
F
V
Q
N
I
A
G
F
S
AN
F
A
TA
L
LLL
L
G
G
A
GI
IG
S
V
I
F
GKL
GN
Q
Y
ASALVS
T
AIA
L
LLV
C
LA
L
L
-
L
--
P
A
A
NS
E
IHLG
V
L
---
SIF
WG
I
A
M
MI
I
GL
GM
Q
V
K
VL
AL
A
PD
A
TD
V
AM
A
LFS
G
I
FN
I
G
I
G
A
GA
LV
G
N
Q
V
-
S
-
L
H
L
S
M
S
M
I
GYV
G
T
V
PA
FAAL
I
W
S
II
I
F
R
R
WPV
TL
fig|444447.5.peg.5639
Escherichia coli O157:H7 str. EC4206 (15-391/396)
V
V
T
LA
V
A
AF
I
F
N
TTEF
V
P
V
GLL
SD
IA
QS
F
H
M
QTAQV
G
I
M
LT
I
YA
W
V
V
A
LMSL
PFM
L
MT
S
QVE
RR
KL
LI
C
L
F
V
V
F
IA
SH
VLS
F
LS
W
S
F
TV
L
V
ISRI
GVA
F
A
H
AI
F
WS
I
T
A
S
L
A
IR
M
A
P
A
GK
R
A
Q
A
LS
L
I
AT
G
T
A
LA
M
VLG
L
PLG
R
I
V
GQ
Y
FGWRMTF
F
AI
G
IGA
L
I
T
L
L
C
L
IKL
LP
LLPS
E
H
S
G
S
L
-
K
SLPLL
F
RRPA
LM
SI
Y
L
L
TV
V
V
VT
A
H
Y
T
A
YSYI
E
P
F
V
Q
N
I
A
G
F
S
AN
F
A
TA
L
LLL
L
G
G
A
GI
IG
S
V
I
F
GKL
GN
Q
Y
ASALVS
T
AIA
L
LLV
C
LA
L
L
-
L
--
P
A
A
NS
E
IHLG
V
L
---
SIF
WG
I
A
M
MI
I
GL
GM
Q
V
K
VL
AL
A
PD
A
TD
V
AM
A
LFS
G
I
FN
I
G
I
G
A
GA
LV
G
N
Q
V
-
S
-
L
H
L
S
M
S
M
I
GYV
G
T
V
PA
FAAL
I
W
S
II
I
F
R
R
WPV
TL
fig|478004.5.peg.2914
Escherichia coli O157:H7 str. EC4401 (15-391/396)
V
V
T
LA
V
A
AF
I
F
N
TTEF
V
P
V
GLL
SD
IA
QS
F
H
M
QTAQV
G
I
M
LT
I
YA
W
V
V
A
LMSL
PFM
L
MT
S
QVE
RR
KL
LI
C
L
F
V
V
F
IA
SH
VLS
F
LS
W
S
F
TV
L
V
ISRI
GVA
F
A
H
AI
F
WS
I
T
A
S
L
A
IR
M
A
P
A
GK
R
A
Q
A
LS
L
I
AT
G
T
A
LA
M
VLG
L
PLG
R
I
V
GQ
Y
FGWRMTF
F
AI
G
IGA
L
I
T
L
L
C
L
IKL
LP
LLPS
E
H
S
G
S
L
-
K
SLPLL
F
RRPA
LM
SI
Y
L
L
TV
V
V
VT
A
H
Y
T
A
YSYI
E
P
F
V
Q
N
I
A
G
F
S
AN
F
A
TA
L
LLL
L
G
G
A
GI
IG
S
V
I
F
GKL
GN
Q
Y
ASALVS
T
AIA
L
LLV
C
LA
L
L
-
L
--
P
A
A
NS
E
IHLG
V
L
---
SIF
WG
I
A
M
MI
I
GL
GM
Q
V
K
VL
AL
A
PD
A
TD
V
AM
A
LFS
G
I
FN
I
G
I
G
A
GA
LV
G
N
Q
V
-
S
-
L
H
L
S
M
S
M
I
GYV
G
T
V
PA
FAAL
I
W
S
II
I
F
R
R
WPV
TL
fig|478005.5.peg.2910
Escherichia coli O157:H7 str. EC4486 (15-391/396)
V
V
T
LA
V
A
AF
I
F
N
TTEF
V
P
V
GLL
SD
IA
QS
F
H
M
QTAQV
G
I
M
LT
I
YA
W
V
V
A
LMSL
PFM
L
MT
S
QVE
RR
KL
LI
C
L
F
V
V
F
IA
SH
VLS
F
LS
W
S
F
TV
L
V
ISRI
GVA
F
A
H
AI
F
WS
I
T
A
S
L
A
IR
M
A
P
A
GK
R
A
Q
A
LS
L
I
AT
G
T
A
LA
M
VLG
L
PLG
R
I
V
GQ
Y
FGWRMTF
F
AI
G
IGA
L
I
T
L
L
C
L
IKL
LP
LLPS
E
H
S
G
S
L
-
K
SLPLL
F
RRPA
LM
SI
Y
L
L
TV
V
V
VT
A
H
Y
T
A
YSYI
E
P
F
V
Q
N
I
A
G
F
S
AN
F
A
TA
L
LLL
L
G
G
A
GI
IG
S
V
I
F
GKL
GN
Q
Y
ASALVS
T
AIA
L
LLV
C
LA
L
L
-
L
--
P
A
A
NS
E
IHLG
V
L
---
SIF
WG
I
A
M
MI
I
GL
GM
Q
V
K
VL
AL
A
PD
A
TD
V
AM
A
LFS
G
I
FN
I
G
I
G
A
GA
LV
G
N
Q
V
-
S
-
L
H
L
S
M
S
M
I
GYV
G
T
V
PA
FAAL
I
W
S
II
I
F
R
R
WPV
TL
fig|544404.4.peg.2051
Escherichia coli O157:H7 str. TW14359 (15-391/396)
V
V
T
LA
V
A
AF
I
F
N
TTEF
V
P
V
GLL
SD
IA
QS
F
H
M
QTAQV
G
I
M
LT
I
YA
W
V
V
A
LMSL
PFM
L
MT
S
QVE
RR
KL
LI
C
L
F
V
V
F
IA
SH
VLS
F
LS
W
S
F
TV
L
V
ISRI
GVA
F
A
H
AI
F
WS
I
T
A
S
L
A
IR
M
A
P
A
GK
R
A
Q
A
LS
L
I
AT
G
T
A
LA
M
VLG
L
PLG
R
I
V
GQ
Y
FGWRMTF
F
AI
G
IGA
L
I
T
L
L
C
L
IKL
LP
LLPS
E
H
S
G
S
L
-
K
SLPLL
F
RRPA
LM
SI
Y
L
L
TV
V
V
VT
A
H
Y
T
A
YSYI
E
P
F
V
Q
N
I
A
G
F
S
AN
F
A
TA
L
LLL
L
G
G
A
GI
IG
S
V
I
F
GKL
GN
Q
Y
ASALVS
T
AIA
L
LLV
C
LA
L
L
-
L
--
P
A
A
NS
E
IHLG
V
L
---
SIF
WG
I
A
M
MI
I
GL
GM
Q
V
K
VL
AL
A
PD
A
TD
V
AM
A
LFS
G
I
FN
I
G
I
G
A
GA
LV
G
N
Q
V
-
S
-
L
H
L
S
M
S
M
I
GYV
G
T
V
PA
FAAL
I
W
S
II
I
F
R
R
WPV
TL
fig|749545.3.peg.5072
Escherichia coli MS 182-1 (15-391/396)
V
V
T
LA
V
A
AF
I
F
N
TTEF
V
P
V
GLL
SD
IA
QS
F
H
M
QTAQV
G
I
M
LT
I
YA
W
V
V
A
LMSL
PFM
L
MT
S
QVE
RR
KL
LI
C
L
F
V
V
F
IA
SH
VLS
F
LS
W
S
F
TV
L
V
ISRI
GVA
F
A
H
AI
F
WS
I
T
A
S
L
A
IR
M
A
P
A
GK
R
A
Q
A
LS
L
I
AT
G
T
A
LA
M
VLG
L
PLG
R
I
V
GQ
Y
FGWRMTF
F
AI
G
IGA
L
I
T
L
L
C
L
IKL
LP
LLPS
E
H
S
G
S
L
-
K
SLPLL
F
RRPA
LM
SI
Y
L
L
TV
V
V
VT
A
H
Y
T
A
YSYI
E
P
F
V
Q
N
I
A
G
F
S
AN
F
A
TA
L
LLL
L
G
G
A
GI
IG
S
V
I
F
GKL
GN
Q
Y
ASALVS
T
AIA
L
LLV
C
LA
L
L
-
L
--
P
A
T
NS
E
IHLG
V
L
---
SIF
WG
I
A
M
MI
I
GL
GM
Q
V
K
VL
AL
A
PD
A
TD
V
AM
A
LFS
G
I
FN
I
G
I
G
A
GA
LV
G
N
Q
V
-
S
-
L
HW
S
M
S
M
I
GYV
GA
V
PA
FAAL
I
W
S
II
I
F
R
R
WPV
TL
fig|749532.3.peg.1399
Escherichia coli MS 78-1 (15-391/396)
V
V
T
LA
V
A
AF
I
F
N
TTEF
V
P
V
GLL
SD
IA
QS
F
H
M
QTAQV
G
I
M
LT
I
YA
W
V
V
A
LMSL
PFM
L
MT
S
QVE
RR
KL
LI
C
L
F
V
V
F
IA
SH
VLS
F
LS
W
S
F
TV
L
V
ISRI
GVA
F
A
H
AI
F
WS
I
T
A
S
L
A
IR
M
A
P
A
GK
R
A
Q
A
LS
L
I
AT
G
T
A
LA
M
VLG
L
PLG
R
I
V
GQ
Y
FGWRMTF
F
AI
G
IGA
L
I
T
L
L
C
L
IKL
LP
LLPS
E
H
S
G
S
L
-
K
SLPLL
F
RRPA
LM
SI
Y
L
L
TV
V
V
VT
A
H
Y
T
A
YSYI
E
P
F
V
Q
N
I
A
G
F
S
AN
F
A
TA
L
LLL
L
G
G
A
GI
IG
S
V
I
F
GKL
GN
Q
Y
ASALVS
T
AIA
L
LLV
C
LA
L
L
-
L
--
P
A
T
NS
E
IHLG
V
L
---
SIF
WG
I
A
M
MI
I
GL
GM
Q
V
K
VL
AL
A
PD
A
TD
V
AM
A
LFS
G
I
FN
I
G
I
G
A
GA
LV
G
N
Q
V
-
S
-
L
HW
S
M
S
M
I
GYV
GA
V
PA
FAAL
I
W
S
II
I
F
R
R
WPV
TL
fig|6666666.5357.peg.2873
Escherichia coli TY-2482 (15-391/396)
V
V
T
LA
V
A
AF
I
F
N
TTEF
V
P
V
GLL
SD
IA
QS
F
H
M
QTAQV
G
I
M
LT
I
YA
W
V
V
A
LMSL
PFM
L
MT
S
QVE
RR
KL
LI
C
L
F
V
V
F
IA
SH
VLS
F
LS
W
S
F
TV
L
V
ISRI
GVA
F
A
H
AI
F
WS
I
T
A
S
L
A
IR
M
A
P
A
GK
R
A
Q
A
LS
L
I
AT
G
T
A
LA
M
VLG
L
PLG
R
I
V
GQ
Y
FGWRMTF
F
AI
G
IGA
L
I
T
L
L
C
L
IKL
LP
LLPS
E
H
S
G
S
L
-
K
SLPLL
F
RRPA
LM
SI
Y
L
L
TV
V
V
VT
A
H
Y
T
A
YSYI
E
P
F
V
Q
N
I
A
G
F
S
AN
F
A
TA
L
LLL
L
G
G
A
GI
IG
S
V
I
F
GKL
GN
Q
Y
ASALVS
T
AIA
L
LLV
C
LA
L
L
-
L
--
P
A
A
NS
E
IHLG
V
L
---
SIF
WG
I
A
M
MI
I
GL
GM
Q
V
K
VL
AL
A
PD
A
TD
V
AM
A
LFS
G
I
FN
I
G
I
G
A
GA
LV
G
N
Q
V
-
S
-
L
HW
S
M
S
M
I
GYV
GA
V
PA
FAAL
I
W
S
II
I
F
R
R
WPV
TL
fig|358709.5.peg.1044
Escherichia coli 101-1 (15-391/396)
V
V
T
LA
V
A
AF
I
F
N
TTEF
V
P
V
GLL
SD
IA
QS
F
H
M
QTAQV
G
I
M
LT
I
YA
W
V
V
A
LMSL
PFM
L
MT
S
QVE
RR
KL
LI
C
L
F
V
V
F
IA
SH
VLS
F
LS
W
S
F
TV
L
V
ISRI
GVA
F
A
H
AI
F
WS
I
T
A
S
L
A
IR
M
A
P
A
GK
R
A
Q
A
LS
L
I
AT
G
T
A
LA
M
VLG
L
PLG
R
I
V
GQ
Y
FGWRMTF
F
AI
G
IGA
L
I
T
L
L
C
L
IKL
LP
LLPS
E
H
S
G
S
L
-
K
SLPLL
F
RRPA
LM
SI
Y
L
L
TV
V
V
VT
A
H
Y
T
A
YSYI
E
P
F
V
Q
N
I
A
G
F
S
AN
F
A
TA
L
LLL
L
G
G
A
GI
IG
S
V
I
F
GKL
GN
Q
Y
ASALVS
T
AIA
L
LLV
C
LA
L
L
-
L
--
P
A
A
NS
E
IHLG
V
L
---
SIF
WG
I
A
M
MI
I
GL
GM
Q
V
K
VL
AL
A
PD
A
TD
V
AM
A
LFS
G
I
FN
I
G
I
G
A
GA
LV
G
N
Q
V
-
S
-
L
HW
S
M
S
M
I
GYV
GA
V
PA
FAAL
I
W
S
II
I
F
R
R
WPV
TL
fig|670888.3.peg.2229
Escherichia coli 1827-70 (15-391/396)
V
V
T
LA
V
A
AF
I
F
N
TTEF
V
P
V
GLL
SD
IA
QS
F
H
M
QTAQV
G
I
M
LT
I
YA
W
V
V
A
LMSL
PFM
L
MT
S
QVE
RR
KL
LI
C
L
F
V
V
F
IA
SH
VLS
F
LS
W
S
F
TV
L
V
ISRI
GVA
F
A
H
AI
F
WS
I
T
A
S
L
A
IR
M
A
P
A
GK
R
A
Q
A
LS
L
I
AT
G
T
A
LA
M
VLG
L
PLG
R
I
V
GQ
Y
FGWRMTF
F
AI
G
IGA
L
I
T
L
L
C
L
IKL
LP
LLPS
E
H
S
G
S
L
-
K
SLPLL
F
RRPA
LM
SI
Y
L
L
TV
V
V
VT
A
H
Y
T
A
YSYI
E
P
F
V
Q
N
I
A
G
F
S
AN
F
A
TA
L
LLL
L
G
G
A
GI
IG
S
V
I
F
GKL
GN
Q
Y
ASALVS
T
AIA
L
LLV
C
LA
L
L
-
L
--
P
A
A
NS
E
IHLG
V
L
---
SIF
WG
I
A
M
MI
I
GL
GM
Q
V
K
VL
AL
A
PD
A
TD
V
AM
A
LFS
G
I
FN
I
G
I
G
A
GA
LV
G
N
Q
V
-
S
-
L
HW
S
M
S
M
I
GYV
GA
V
PA
FAAL
I
W
S
II
I
F
R
R
WPV
TL
fig|344610.3.peg.3502
Escherichia coli 53638 (15-391/396)
V
V
T
LA
V
A
AF
I
F
N
TTEF
V
P
V
GLL
SD
IA
QS
F
H
M
QTAQV
G
I
M
LT
I
YA
W
V
V
A
LMSL
PFM
L
MT
S
QVE
RR
KL
LI
C
L
F
V
V
F
IA
SH
VLS
F
LS
W
S
F
TV
L
V
ISRI
GVA
F
A
H
AI
F
WS
I
T
A
S
L
A
IR
M
A
P
A
GK
R
A
Q
A
LS
L
I
AT
G
T
A
LA
M
VLG
L
PLG
R
I
V
GQ
Y
FGWRMTF
F
AI
G
IGA
L
I
T
L
L
C
L
IKL
LP
LLPS
E
H
S
G
S
L
-
K
SLPLL
F
RRPA
LM
SI
Y
L
L
TV
V
V
VT
A
H
Y
T
A
YSYI
E
P
F
V
Q
N
I
A
G
F
S
AN
F
A
TA
L
LLL
L
G
G
A
GI
IG
S
V
I
F
GKL
GN
Q
Y
ASALVS
T
AIA
L
LLV
C
LA
L
L
-
L
--
P
A
A
NS
E
IHLG
V
L
---
SIF
WG
I
A
M
MI
I
GL
GM
Q
V
K
VL
AL
A
PD
A
TD
V
AM
A
LFS
G
I
FN
I
G
I
G
A
GA
LV
G
N
Q
V
-
S
-
L
HW
S
M
S
M
I
GYV
GA
V
PA
FAAL
I
W
S
II
I
F
R
R
WPV
TL
fig|344610.7.peg.5209
Escherichia coli 53638 (15-391/396)
V
V
T
LA
V
A
AF
I
F
N
TTEF
V
P
V
GLL
SD
IA
QS
F
H
M
QTAQV
G
I
M
LT
I
YA
W
V
V
A
LMSL
PFM
L
MT
S
QVE
RR
KL
LI
C
L
F
V
V
F
IA
SH
VLS
F
LS
W
S
F
TV
L
V
ISRI
GVA
F
A
H
AI
F
WS
I
T
A
S
L
A
IR
M
A
P
A
GK
R
A
Q
A
LS
L
I
AT
G
T
A
LA
M
VLG
L
PLG
R
I
V
GQ
Y
FGWRMTF
F
AI
G
IGA
L
I
T
L
L
C
L
IKL
LP
LLPS
E
H
S
G
S
L
-
K
SLPLL
F
RRPA
LM
SI
Y
L
L
TV
V
V
VT
A
H
Y
T
A
YSYI
E
P
F
V
Q
N
I
A
G
F
S
AN
F
A
TA
L
LLL
L
G
G
A
GI
IG
S
V
I
F
GKL
GN
Q
Y
ASALVS
T
AIA
L
LLV
C
LA
L
L
-
L
--
P
A
A
NS
E
IHLG
V
L
---
SIF
WG
I
A
M
MI
I
GL
GM
Q
V
K
VL
AL
A
PD
A
TD
V
AM
A
LFS
G
I
FN
I
G
I
G
A
GA
LV
G
N
Q
V
-
S
-
L
HW
S
M
S
M
I
GYV
GA
V
PA
FAAL
I
W
S
II
I
F
R
R
WPV
TL
fig|585055.8.peg.1696
Escherichia coli 55989 (15-391/396)
V
V
T
LA
V
A
AF
I
F
N
TTEF
V
P
V
GLL
SD
IA
QS
F
H
M
QTAQV
G
I
M
LT
I
YA
W
V
V
A
LMSL
PFM
L
MT
S
QVE
RR
KL
LI
C
L
F
V
V
F
IA
SH
VLS
F
LS
W
S
F
TV
L
V
ISRI
GVA
F
A
H
AI
F
WS
I
T
A
S
L
A
IR
M
A
P
A
GK
R
A
Q
A
LS
L
I
AT
G
T
A
LA
M
VLG
L
PLG
R
I
V
GQ
Y
FGWRMTF
F
AI
G
IGA
L
I
T
L
L
C
L
IKL
LP
LLPS
E
H
S
G
S
L
-
K
SLPLL
F
RRPA
LM
SI
Y
L
L
TV
V
V
VT
A
H
Y
T
A
YSYI
E
P
F
V
Q
N
I
A
G
F
S
AN
F
A
TA
L
LLL
L
G
G
A
GI
IG
S
V
I
F
GKL
GN
Q
Y
ASALVS
T
AIA
L
LLV
C
LA
L
L
-
L
--
P
A
A
NS
E
IHLG
V
L
---
SIF
WG
I
A
M
MI
I
GL
GM
Q
V
K
VL
AL
A
PD
A
TD
V
AM
A
LFS
G
I
FN
I
G
I
G
A
GA
LV
G
N
Q
V
-
S
-
L
HW
S
M
S
M
I
GYV
GA
V
PA
FAAL
I
W
S
II
I
F
R
R
WPV
TL
fig|481805.3.peg.2290
Escherichia coli ATCC 8739 (15-391/396)
V
V
T
LA
V
A
AF
I
F
N
TTEF
V
P
V
GLL
SD
IA
QS
F
H
M
QTAQV
G
I
M
LT
I
YA
W
V
V
A
LMSL
PFM
L
MT
S
QVE
RR
KL
LI
C
L
F
V
V
F
IA
SH
VLS
F
LS
W
S
F
TV
L
V
ISRI
GVA
F
A
H
AI
F
WS
I
T
A
S
L
A
IR
M
A
P
A
GK
R
A
Q
A
LS
L
I
AT
G
T
A
LA
M
VLG
L
PLG
R
I
V
GQ
Y
FGWRMTF
F
AI
G
IGA
L
I
T
L
L
C
L
IKL
LP
LLPS
E
H
S
G
S
L
-
K
SLPLL
F
RRPA
LM
SI
Y
L
L
TV
V
V
VT
A
H
Y
T
A
YSYI
E
P
F
V
Q
N
I
A
G
F
S
AN
F
A
TA
L
LLL
L
G
G
A
GI
IG
S
V
I
F
GKL
GN
Q
Y
ASALVS
T
AIA
L
LLV
C
LA
L
L
-
L
--
P
A
A
NS
E
IHLG
V
L
---
SIF
WG
I
A
M
MI
I
GL
GM
Q
V
K
VL
AL
A
PD
A
TD
V
AM
A
LFS
G
I
FN
I
G
I
G
A
GA
LV
G
N
Q
V
-
S
-
L
HW
S
M
S
M
I
GYV
GA
V
PA
FAAL
I
W
S
II
I
F
R
R
WPV
TL
fig|481805.6.peg.2280
Escherichia coli ATCC 8739 (15-391/396)
V
V
T
LA
V
A
AF
I
F
N
TTEF
V
P
V
GLL
SD
IA
QS
F
H
M
QTAQV
G
I
M
LT
I
YA
W
V
V
A
LMSL
PFM
L
MT
S
QVE
RR
KL
LI
C
L
F
V
V
F
IA
SH
VLS
F
LS
W
S
F
TV
L
V
ISRI
GVA
F
A
H
AI
F
WS
I
T
A
S
L
A
IR
M
A
P
A
GK
R
A
Q
A
LS
L
I
AT
G
T
A
LA
M
VLG
L
PLG
R
I
V
GQ
Y
FGWRMTF
F
AI
G
IGA
L
I
T
L
L
C
L
IKL
LP
LLPS
E
H
S
G
S
L
-
K
SLPLL
F
RRPA
LM
SI
Y
L
L
TV
V
V
VT
A
H
Y
T
A
YSYI
E
P
F
V
Q
N
I
A
G
F
S
AN
F
A
TA
L
LLL
L
G
G
A
GI
IG
S
V
I
F
GKL
GN
Q
Y
ASALVS
T
AIA
L
LLV
C
LA
L
L
-
L
--
P
A
A
NS
E
IHLG
V
L
---
SIF
WG
I
A
M
MI
I
GL
GM
Q
V
K
VL
AL
A
PD
A
TD
V
AM
A
LFS
G
I
FN
I
G
I
G
A
GA
LV
G
N
Q
V
-
S
-
L
HW
S
M
S
M
I
GYV
GA
V
PA
FAAL
I
W
S
II
I
F
R
R
WPV
TL
fig|413997.3.peg.1563
Escherichia coli B str. REL606 (15-391/396)
V
V
T
LA
V
A
AF
I
F
N
TTEF
V
P
V
GLL
SD
IA
QS
F
H
M
QTAQV
G
I
M
LT
I
YA
W
V
V
A
LMSL
PFM
L
MT
S
QVE
RR
KL
LI
C
L
F
V
V
F
IA
SH
VLS
F
LS
W
S
F
TV
L
V
ISRI
GVA
F
A
H
AI
F
WS
I
T
A
S
L
A
IR
M
A
P
A
GK
R
A
Q
A
LS
L
I
AT
G
T
A
LA
M
VLG
L
PLG
R
I
V
GQ
Y
FGWRMTF
F
AI
G
IGA
L
I
T
L
L
C
L
IKL
LP
LLPS
E
H
S
G
S
L
-
K
SLPLL
F
RRPA
LM
SI
Y
L
L
TV
V
V
VT
A
H
Y
T
A
YSYI
E
P
F
V
Q
N
I
A
G
F
S
AN
F
A
TA
L
LLL
L
G
G
A
GI
IG
S
V
I
F
GKL
GN
Q
Y
ASALVS
T
AIA
L
LLV
C
LA
L
L
-
L
--
P
A
A
NS
E
IHLG
V
L
---
SIF
WG
I
A
M
MI
I
GL
GM
Q
V
K
VL
AL
A
PD
A
TD
V
AM
A
LFS
G
I
FN
I
G
I
G
A
GA
LV
G
N
Q
V
-
S
-
L
HW
S
M
S
M
I
GYV
GA
V
PA
FAAL
I
W
S
II
I
F
R
R
WPV
TL
fig|550676.3.peg.1867
Escherichia coli B185 (15-391/396)
V
V
T
LA
V
A
AF
I
F
N
TTEF
V
P
V
GLL
SD
IA
QS
F
H
M
QTAQV
G
I
M
LT
I
YA
W
V
V
A
LMSL
PFM
L
MT
S
QVE
RR
KL
LI
C
L
F
V
V
F
IA
SH
VLS
F
LS
W
S
F
TV
L
V
ISRI
GVA
F
A
H
AI
F
WS
I
T
A
S
L
A
IR
M
A
P
A
GK
R
A
Q
A
LS
L
I
AT
G
T
A
LA
M
VLG
L
PLG
R
I
V
GQ
Y
FGWRMTF
F
AI
G
IGA
L
I
T
L
L
C
L
IKL
LP
LLPS
E
H
S
G
S
L
-
K
SLPLL
F
RRPA
LM
SI
Y
L
L
TV
V
V
VT
A
H
Y
T
A
YSYI
E
P
F
V
Q
N
I
A
G
F
S
AN
F
A
TA
L
LLL
L
G
G
A
GI
IG
S
V
I
F
GKL
GN
Q
Y
ASALVS
T
AIA
L
LLV
C
LA
L
L
-
L
--
P
A
A
NS
E
IHLG
V
L
---
SIF
WG
I
A
M
MI
I
GL
GM
Q
V
K
VL
AL
A
PD
A
TD
V
AM
A
LFS
G
I
FN
I
G
I
G
A
GA
LV
G
N
Q
V
-
S
-
L
HW
S
M
S
M
I
GYV
GA
V
PA
FAAL
I
W
S
II
I
F
R
R
WPV
TL
fig|340184.3.peg.28
Escherichia coli B7A (15-391/396)
V
V
T
LA
V
A
AF
I
F
N
TTEF
V
P
V
GLL
SD
IA
QS
F
H
M
QTAQV
G
I
M
LT
I
YA
W
V
V
A
LMSL
PFM
L
MT
S
QVE
RR
KL
LI
C
L
F
V
V
F
IA
SH
VLS
F
LS
W
S
F
TV
L
V
ISRI
GVA
F
A
H
AI
F
WS
I
T
A
S
L
A
IR
M
A
P
A
GK
R
A
Q
A
LS
L
I
AT
G
T
A
LA
M
VLG
L
PLG
R
I
V
GQ
Y
FGWRMTF
F
AI
G
IGA
L
I
T
L
L
C
L
IKL
LP
LLPS
E
H
S
G
S
L
-
K
SLPLL
F
RRPA
LM
SI
Y
L
L
TV
V
V
VT
A
H
Y
T
A
YSYI
E
P
F
V
Q
N
I
A
G
F
S
AN
F
A
TA
L
LLL
L
G
G
A
GI
IG
S
V
I
F
GKL
GN
Q
Y
ASALVS
T
AIA
L
LLV
C
LA
L
L
-
L
--
P
A
A
NS
E
IHLG
V
L
---
SIF
WG
I
A
M
MI
I
GL
GM
Q
V
K
VL
AL
A
PD
A
TD
V
AM
A
LFS
G
I
FN
I
G
I
G
A
GA
LV
G
N
Q
V
-
S
-
L
HW
S
M
S
M
I
GYV
GA
V
PA
FAAL
I
W
S
II
I
F
R
R
WPV
TL
fig|340184.6.peg.32
Escherichia coli B7A (15-391/396)
V
V
T
LA
V
A
AF
I
F
N
TTEF
V
P
V
GLL
SD
IA
QS
F
H
M
QTAQV
G
I
M
LT
I
YA
W
V
V
A
LMSL
PFM
L
MT
S
QVE
RR
KL
LI
C
L
F
V
V
F
IA
SH
VLS
F
LS
W
S
F
TV
L
V
ISRI
GVA
F
A
H
AI
F
WS
I
T
A
S
L
A
IR
M
A
P
A
GK
R
A
Q
A
LS
L
I
AT
G
T
A
LA
M
VLG
L
PLG
R
I
V
GQ
Y
FGWRMTF
F
AI
G
IGA
L
I
T
L
L
C
L
IKL
LP
LLPS
E
H
S
G
S
L
-
K
SLPLL
F
RRPA
LM
SI
Y
L
L
TV
V
V
VT
A
H
Y
T
A
YSYI
E
P
F
V
Q
N
I
A
G
F
S
AN
F
A
TA
L
LLL
L
G
G
A
GI
IG
S
V
I
F
GKL
GN
Q
Y
ASALVS
T
AIA
L
LLV
C
LA
L
L
-
L
--
P
A
A
NS
E
IHLG
V
L
---
SIF
WG
I
A
M
MI
I
GL
GM
Q
V
K
VL
AL
A
PD
A
TD
V
AM
A
LFS
G
I
FN
I
G
I
G
A
GA
LV
G
N
Q
V
-
S
-
L
HW
S
M
S
M
I
GYV
GA
V
PA
FAAL
I
W
S
II
I
F
R
R
WPV
TL
fig|511693.5.peg.1602
Escherichia coli BL21 (15-391/396)
V
V
T
LA
V
A
AF
I
F
N
TTEF
V
P
V
GLL
SD
IA
QS
F
H
M
QTAQV
G
I
M
LT
I
YA
W
V
V
A
LMSL
PFM
L
MT
S
QVE
RR
KL
LI
C
L
F
V
V
F
IA
SH
VLS
F
LS
W
S
F
TV
L
V
ISRI
GVA
F
A
H
AI
F
WS
I
T
A
S
L
A
IR
M
A
P
A
GK
R
A
Q
A
LS
L
I
AT
G
T
A
LA
M
VLG
L
PLG
R
I
V
GQ
Y
FGWRMTF
F
AI
G
IGA
L
I
T
L
L
C
L
IKL
LP
LLPS
E
H
S
G
S
L
-
K
SLPLL
F
RRPA
LM
SI
Y
L
L
TV
V
V
VT
A
H
Y
T
A
YSYI
E
P
F
V
Q
N
I
A
G
F
S
AN
F
A
TA
L
LLL
L
G
G
A
GI
IG
S
V
I
F
GKL
GN
Q
Y
ASALVS
T
AIA
L
LLV
C
LA
L
L
-
L
--
P
A
A
NS
E
IHLG
V
L
---
SIF
WG
I
A
M
MI
I
GL
GM
Q
V
K
VL
AL
A
PD
A
TD
V
AM
A
LFS
G
I
FN
I
G
I
G
A
GA
LV
G
N
Q
V
-
S
-
L
HW
S
M
S
M
I
GYV
GA
V
PA
FAAL
I
W
S
II
I
F
R
R
WPV
TL
fig|469008.4.peg.2172
Escherichia coli BL21(DE3) (15-391/396)
V
V
T
LA
V
A
AF
I
F
N
TTEF
V
P
V
GLL
SD
IA
QS
F
H
M
QTAQV
G
I
M
LT
I
YA
W
V
V
A
LMSL
PFM
L
MT
S
QVE
RR
KL
LI
C
L
F
V
V
F
IA
SH
VLS
F
LS
W
S
F
TV
L
V
ISRI
GVA
F
A
H
AI
F
WS
I
T
A
S
L
A
IR
M
A
P
A
GK
R
A
Q
A
LS
L
I
AT
G
T
A
LA
M
VLG
L
PLG
R
I
V
GQ
Y
FGWRMTF
F
AI
G
IGA
L
I
T
L
L
C
L
IKL
LP
LLPS
E
H
S
G
S
L
-
K
SLPLL
F
RRPA
LM
SI
Y
L
L
TV
V
V
VT
A
H
Y
T
A
YSYI
E
P
F
V
Q
N
I
A
G
F
S
AN
F
A
TA
L
LLL
L
G
G
A
GI
IG
S
V
I
F
GKL
GN
Q
Y
ASALVS
T
AIA
L
LLV
C
LA
L
L
-
L
--
P
A
A
NS
E
IHLG
V
L
---
SIF
WG
I
A
M
MI
I
GL
GM
Q
V
K
VL
AL
A
PD
A
TD
V
AM
A
LFS
G
I
FN
I
G
I
G
A
GA
LV
G
N
Q
V
-
S
-
L
HW
S
M
S
M
I
GYV
GA
V
PA
FAAL
I
W
S
II
I
F
R
R
WPV
TL
fig|595496.3.peg.1487
Escherichia coli BW2952 (15-391/396)
V
V
T
LA
V
A
AF
I
F
N
TTEF
V
P
V
GLL
SD
IA
QS
F
H
M
QTAQV
G
I
M
LT
I
YA
W
V
V
A
LMSL
PFM
L
MT
S
QVE
RR
KL
LI
C
L
F
V
V
F
IA
SH
VLS
F
LS
W
S
F
TV
L
V
ISRI
GVA
F
A
H
AI
F
WS
I
T
A
S
L
A
IR
M
A
P
A
GK
R
A
Q
A
LS
L
I
AT
G
T
A
LA
M
VLG
L
PLG
R
I
V
GQ
Y
FGWRMTF
F
AI
G
IGA
L
I
T
L
L
C
L
IKL
LP
LLPS
E
H
S
G
S
L
-
K
SLPLL
F
RRPA
LM
SI
Y
L
L
TV
V
V
VT
A
H
Y
T
A
YSYI
E
P
F
V
Q
N
I
A
G
F
S
AN
F
A
TA
L
LLL
L
G
G
A
GI
IG
S
V
I
F
GKL
GN
Q
Y
ASALVS
T
AIA
L
LLV
C
LA
L
L
-
L
--
P
A
A
NS
E
IHLG
V
L
---
SIF
WG
I
A
M
MI
I
GL
GM
Q
V
K
VL
AL
A
PD
A
TD
V
AM
A
LFS
G
I
FN
I
G
I
G
A
GA
LV
G
N
Q
V
-
S
-
L
HW
S
M
S
M
I
GYV
GA
V
PA
FAAL
I
W
S
II
I
F
R
R
WPV
TL
fig|536056.3.peg.2227
Escherichia coli DH1 (15-391/396)
V
V
T
LA
V
A
AF
I
F
N
TTEF
V
P
V
GLL
SD
IA
QS
F
H
M
QTAQV
G
I
M
LT
I
YA
W
V
V
A
LMSL
PFM
L
MT
S
QVE
RR
KL
LI
C
L
F
V
V
F
IA
SH
VLS
F
LS
W
S
F
TV
L
V
ISRI
GVA
F
A
H
AI
F
WS
I
T
A
S
L
A
IR
M
A
P
A
GK
R
A
Q
A
LS
L
I
AT
G
T
A
LA
M
VLG
L
PLG
R
I
V
GQ
Y
FGWRMTF
F
AI
G
IGA
L
I
T
L
L
C
L
IKL
LP
LLPS
E
H
S
G
S
L
-
K
SLPLL
F
RRPA
LM
SI
Y
L
L
TV
V
V
VT
A
H
Y
T
A
YSYI
E
P
F
V
Q
N
I
A
G
F
S
AN
F
A
TA
L
LLL
L
G
G
A
GI
IG
S
V
I
F
GKL
GN
Q
Y
ASALVS
T
AIA
L
LLV
C
LA
L
L
-
L
--
P
A
A
NS
E
IHLG
V
L
---
SIF
WG
I
A
M
MI
I
GL
GM
Q
V
K
VL
AL
A
PD
A
TD
V
AM
A
LFS
G
I
FN
I
G
I
G
A
GA
LV
G
N
Q
V
-
S
-
L
HW
S
M
S
M
I
GYV
GA
V
PA
FAAL
I
W
S
II
I
F
R
R
WPV
TL
fig|340186.3.peg.97
Escherichia coli E110019 (15-391/396)
V
V
T
LA
V
A
AF
I
F
N
TTEF
V
P
V
GLL
SD
IA
QS
F
H
M
QTAQV
G
I
M
LT
I
YA
W
V
V
A
LMSL
PFM
L
MT
S
QVE
RR
KL
LI
C
L
F
V
V
F
IA
SH
VLS
F
LS
W
S
F
TV
L
V
ISRI
GVA
F
A
H
AI
F
WS
I
T
A
S
L
A
IR
M
A
P
A
GK
R
A
Q
A
LS
L
I
AT
G
T
A
LA
M
VLG
L
PLG
R
I
V
GQ
Y
FGWRMTF
F
AI
G
IGA
L
I
T
L
L
C
L
IKL
LP
LLPS
E
H
S
G
S
L
-
K
SLPLL
F
RRPA
LM
SI
Y
L
L
TV
V
V
VT
A
H
Y
T
A
YSYI
E
P
F
V
Q
N
I
A
G
F
S
AN
F
A
TA
L
LLL
L
G
G
A
GI
IG
S
V
I
F
GKL
GN
Q
Y
ASALVS
T
AIA
L
LLV
C
LA
L
L
-
L
--
P
A
A
NS
E
IHLG
V
L
---
SIF
WG
I
A
M
MI
I
GL
GM
Q
V
K
VL
AL
A
PD
A
TD
V
AM
A
LFS
G
I
FN
I
G
I
G
A
GA
LV
G
N
Q
V
-
S
-
L
HW
S
M
S
M
I
GYV
GA
V
PA
FAAL
I
W
S
II
I
F
R
R
WPV
TL
fig|340186.5.peg.110
Escherichia coli E110019 (15-391/396)
V
V
T
LA
V
A
AF
I
F
N
TTEF
V
P
V
GLL
SD
IA
QS
F
H
M
QTAQV
G
I
M
LT
I
YA
W
V
V
A
LMSL
PFM
L
MT
S
QVE
RR
KL
LI
C
L
F
V
V
F
IA
SH
VLS
F
LS
W
S
F
TV
L
V
ISRI
GVA
F
A
H
AI
F
WS
I
T
A
S
L
A
IR
M
A
P
A
GK
R
A
Q
A
LS
L
I
AT
G
T
A
LA
M
VLG
L
PLG
R
I
V
GQ
Y
FGWRMTF
F
AI
G
IGA
L
I
T
L
L
C
L
IKL
LP
LLPS
E
H
S
G
S
L
-
K
SLPLL
F
RRPA
LM
SI
Y
L
L
TV
V
V
VT
A
H
Y
T
A
YSYI
E
P
F
V
Q
N
I
A
G
F
S
AN
F
A
TA
L
LLL
L
G
G
A
GI
IG
S
V
I
F
GKL
GN
Q
Y
ASALVS
T
AIA
L
LLV
C
LA
L
L
-
L
--
P
A
A
NS
E
IHLG
V
L
---
SIF
WG
I
A
M
MI
I
GL
GM
Q
V
K
VL
AL
A
PD
A
TD
V
AM
A
LFS
G
I
FN
I
G
I
G
A
GA
LV
G
N
Q
V
-
S
-
L
HW
S
M
S
M
I
GYV
GA
V
PA
FAAL
I
W
S
II
I
F
R
R
WPV
TL
fig|331111.12.peg.2014
Escherichia coli E24377A (15-391/396)
V
V
T
LA
V
A
AF
I
F
N
TTEF
V
P
V
GLL
SD
IA
QS
F
H
M
QTAQV
G
I
M
LT
I
YA
W
V
V
A
LMSL
PFM
L
MT
S
QVE
RR
KL
LI
C
L
F
V
V
F
IA
SH
VLS
F
LS
W
S
F
TV
L
V
ISRI
GVA
F
A
H
AI
F
WS
I
T
A
S
L
A
IR
M
A
P
A
GK
R
A
Q
A
LS
L
I
AT
G
T
A
LA
M
VLG
L
PLG
R
I
V
GQ
Y
FGWRMTF
F
AI
G
IGA
L
I
T
L
L
C
L
IKL
LP
LLPS
E
H
S
G
S
L
-
K
SLPLL
F
RRPA
LM
SI
Y
L
L
TV
V
V
VT
A
H
Y
T
A
YSYI
E
P
F
V
Q
N
I
A
G
F
S
AN
F
A
TA
L
LLL
L
G
G
A
GI
IG
S
V
I
F
GKL
GN
Q
Y
ASALVS
T
AIA
L
LLV
C
LA
L
L
-
L
--
P
A
A
NS
E
IHLG
V
L
---
SIF
WG
I
A
M
MI
I
GL
GM
Q
V
K
VL
AL
A
PD
A
TD
V
AM
A
LFS
G
I
FN
I
G
I
G
A
GA
LV
G
N
Q
V
-
S
-
L
HW
S
M
S
M
I
GYV
GA
V
PA
FAAL
I
W
S
II
I
F
R
R
WPV
TL
fig|331111.3.peg.4170
Escherichia coli E24377A (15-391/396)
V
V
T
LA
V
A
AF
I
F
N
TTEF
V
P
V
GLL
SD
IA
QS
F
H
M
QTAQV
G
I
M
LT
I
YA
W
V
V
A
LMSL
PFM
L
MT
S
QVE
RR
KL
LI
C
L
F
V
V
F
IA
SH
VLS
F
LS
W
S
F
TV
L
V
ISRI
GVA
F
A
H
AI
F
WS
I
T
A
S
L
A
IR
M
A
P
A
GK
R
A
Q
A
LS
L
I
AT
G
T
A
LA
M
VLG
L
PLG
R
I
V
GQ
Y
FGWRMTF
F
AI
G
IGA
L
I
T
L
L
C
L
IKL
LP
LLPS
E
H
S
G
S
L
-
K
SLPLL
F
RRPA
LM
SI
Y
L
L
TV
V
V
VT
A
H
Y
T
A
YSYI
E
P
F
V
Q
N
I
A
G
F
S
AN
F
A
TA
L
LLL
L
G
G
A
GI
IG
S
V
I
F
GKL
GN
Q
Y
ASALVS
T
AIA
L
LLV
C
LA
L
L
-
L
--
P
A
A
NS
E
IHLG
V
L
---
SIF
WG
I
A
M
MI
I
GL
GM
Q
V
K
VL
AL
A
PD
A
TD
V
AM
A
LFS
G
I
FN
I
G
I
G
A
GA
LV
G
N
Q
V
-
S
-
L
HW
S
M
S
M
I
GYV
GA
V
PA
FAAL
I
W
S
II
I
F
R
R
WPV
TL
fig|562.375.peg.3863
Escherichia coli EC4100B (15-391/396)
V
V
T
LA
V
A
AF
I
F
N
TTEF
V
P
V
GLL
SD
IA
QS
F
H
M
QTAQV
G
I
M
LT
I
YA
W
V
V
A
LMSL
PFM
L
MT
S
QVE
RR
KL
LI
C
L
F
V
V
F
IA
SH
VLS
F
LS
W
S
F
TV
L
V
ISRI
GVA
F
A
H
AI
F
WS
I
T
A
S
L
A
IR
M
A
P
A
GK
R
A
Q
A
LS
L
I
AT
G
T
A
LA
M
VLG
L
PLG
R
I
V
GQ
Y
FGWRMTF
F
AI
G
IGA
L
I
T
L
L
C
L
IKL
LP
LLPS
E
H
S
G
S
L
-
K
SLPLL
F
RRPA
LM
SI
Y
L
L
TV
V
V
VT
A
H
Y
T
A
YSYI
E
P
F
V
Q
N
I
A
G
F
S
AN
F
A
TA
L
LLL
L
G
G
A
GI
IG
S
V
I
F
GKL
GN
Q
Y
ASALVS
T
AIA
L
LLV
C
LA
L
L
-
L
--
P
A
A
NS
E
IHLG
V
L
---
SIF
WG
I
A
M
MI
I
GL
GM
Q
V
K
VL
AL
A
PD
A
TD
V
AM
A
LFS
G
I
FN
I
G
I
G
A
GA
LV
G
N
Q
V
-
S
-
L
HW
S
M
S
M
I
GYV
GA
V
PA
FAAL
I
W
S
II
I
F
R
R
WPV
TL
fig|316401.4.peg.1840
Escherichia coli ETEC H10407 (15-391/396)
V
V
T
LA
V
A
AF
I
F
N
TTEF
V
P
V
GLL
SD
IA
QS
F
H
M
QTAQV
G
I
M
LT
I
YA
W
V
V
A
LMSL
PFM
L
MT
S
QVE
RR
KL
LI
C
L
F
V
V
F
IA
SH
VLS
F
LS
W
S
F
TV
L
V
ISRI
GVA
F
A
H
AI
F
WS
I
T
A
S
L
A
IR
M
A
P
A
GK
R
A
Q
A
LS
L
I
AT
G
T
A
LA
M
VLG
L
PLG
R
I
V
GQ
Y
FGWRMTF
F
AI
G
IGA
L
I
T
L
L
C
L
IKL
LP
LLPS
E
H
S
G
S
L
-
K
SLPLL
F
RRPA
LM
SI
Y
L
L
TV
V
V
VT
A
H
Y
T
A
YSYI
E
P
F
V
Q
N
I
A
G
F
S
AN
F
A
TA
L
LLL
L
G
G
A
GI
IG
S
V
I
F
GKL
GN
Q
Y
ASALVS
T
AIA
L
LLV
C
LA
L
L
-
L
--
P
A
A
NS
E
IHLG
V
L
---
SIF
WG
I
A
M
MI
I
GL
GM
Q
V
K
VL
AL
A
PD
A
TD
V
AM
A
LFS
G
I
FN
I
G
I
G
A
GA
LV
G
N
Q
V
-
S
-
L
HW
S
M
S
M
I
GYV
GA
V
PA
FAAL
I
W
S
II
I
F
R
R
WPV
TL
fig|331112.3.peg.1517
Escherichia coli HS (15-391/396)
V
V
T
LA
V
A
AF
I
F
N
TTEF
V
P
V
GLL
SD
IA
QS
F
H
M
QTAQV
G
I
M
LT
I
YA
W
V
V
A
LMSL
PFM
L
MT
S
QVE
RR
KL
LI
C
L
F
V
V
F
IA
SH
VLS
F
LS
W
S
F
TV
L
V
ISRI
GVA
F
A
H
AI
F
WS
I
T
A
S
L
A
IR
M
A
P
A
GK
R
A
Q
A
LS
L
I
AT
G
T
A
LA
M
VLG
L
PLG
R
I
V
GQ
Y
FGWRMTF
F
AI
G
IGA
L
I
T
L
L
C
L
IKL
LP
LLPS
E
H
S
G
S
L
-
K
SLPLL
F
RRPA
LM
SI
Y
L
L
TV
V
V
VT
A
H
Y
T
A
YSYI
E
P
F
V
Q
N
I
A
G
F
S
AN
F
A
TA
L
LLL
L
G
G
A
GI
IG
S
V
I
F
GKL
GN
Q
Y
ASALVS
T
AIA
L
LLV
C
LA
L
L
-
L
--
P
A
A
NS
E
IHLG
V
L
---
SIF
WG
I
A
M
MI
I
GL
GM
Q
V
K
VL
AL
A
PD
A
TD
V
AM
A
LFS
G
I
FN
I
G
I
G
A
GA
LV
G
N
Q
V
-
S
-
L
HW
S
M
S
M
I
GYV
GA
V
PA
FAAL
I
W
S
II
I
F
R
R
WPV
TL
fig|331112.6.peg.1574
Escherichia coli HS (15-391/396)
V
V
T
LA
V
A
AF
I
F
N
TTEF
V
P
V
GLL
SD
IA
QS
F
H
M
QTAQV
G
I
M
LT
I
YA
W
V
V
A
LMSL
PFM
L
MT
S
QVE
RR
KL
LI
C
L
F
V
V
F
IA
SH
VLS
F
LS
W
S
F
TV
L
V
ISRI
GVA
F
A
H
AI
F
WS
I
T
A
S
L
A
IR
M
A
P
A
GK
R
A
Q
A
LS
L
I
AT
G
T
A
LA
M
VLG
L
PLG
R
I
V
GQ
Y
FGWRMTF
F
AI
G
IGA
L
I
T
L
L
C
L
IKL
LP
LLPS
E
H
S
G
S
L
-
K
SLPLL
F
RRPA
LM
SI
Y
L
L
TV
V
V
VT
A
H
Y
T
A
YSYI
E
P
F
V
Q
N
I
A
G
F
S
AN
F
A
TA
L
LLL
L
G
G
A
GI
IG
S
V
I
F
GKL
GN
Q
Y
ASALVS
T
AIA
L
LLV
C
LA
L
L
-
L
--
P
A
A
NS
E
IHLG
V
L
---
SIF
WG
I
A
M
MI
I
GL
GM
Q
V
K
VL
AL
A
PD
A
TD
V
AM
A
LFS
G
I
FN
I
G
I
G
A
GA
LV
G
N
Q
V
-
S
-
L
HW
S
M
S
M
I
GYV
GA
V
PA
FAAL
I
W
S
II
I
F
R
R
WPV
TL
fig|585034.4.peg.1524
Escherichia coli IAI1 (15-391/396)
V
V
T
LA
V
A
AF
I
F
N
TTEF
V
P
V
GLL
SD
IA
QS
F
H
M
QTAQV
G
I
M
LT
I
YA
W
V
V
A
LMSL
PFM
L
MT
S
QVE
RR
KL
LI
C
L
F
V
V
F
IA
SH
VLS
F
LS
W
S
F
TV
L
V
ISRI
GVA
F
A
H
AI
F
WS
I
T
A
S
L
A
IR
M
A
P
A
GK
R
A
Q
A
LS
L
I
AT
G
T
A
LA
M
VLG
L
PLG
R
I
V
GQ
Y
FGWRMTF
F
AI
G
IGA
L
I
T
L
L
C
L
IKL
LP
LLPS
E
H
S
G
S
L
-
K
SLPLL
F
RRPA
LM
SI
Y
L
L
TV
V
V
VT
A
H
Y
T
A
YSYI
E
P
F
V
Q
N
I
A
G
F
S
AN
F
A
TA
L
LLL
L
G
G
A
GI
IG
S
V
I
F
GKL
GN
Q
Y
ASALVS
T
AIA
L
LLV
C
LA
L
L
-
L
--
P
A
A
NS
E
IHLG
V
L
---
SIF
WG
I
A
M
MI
I
GL
GM
Q
V
K
VL
AL
A
PD
A
TD
V
AM
A
LFS
G
I
FN
I
G
I
G
A
GA
LV
G
N
Q
V
-
S
-
L
HW
S
M
S
M
I
GYV
GA
V
PA
FAAL
I
W
S
II
I
F
R
R
WPV
TL
fig|585034.5.peg.1521
Escherichia coli IAI1 (15-391/396)
V
V
T
LA
V
A
AF
I
F
N
TTEF
V
P
V
GLL
SD
IA
QS
F
H
M
QTAQV
G
I
M
LT
I
YA
W
V
V
A
LMSL
PFM
L
MT
S
QVE
RR
KL
LI
C
L
F
V
V
F
IA
SH
VLS
F
LS
W
S
F
TV
L
V
ISRI
GVA
F
A
H
AI
F
WS
I
T
A
S
L
A
IR
M
A
P
A
GK
R
A
Q
A
LS
L
I
AT
G
T
A
LA
M
VLG
L
PLG
R
I
V
GQ
Y
FGWRMTF
F
AI
G
IGA
L
I
T
L
L
C
L
IKL
LP
LLPS
E
H
S
G
S
L
-
K
SLPLL
F
RRPA
LM
SI
Y
L
L
TV
V
V
VT
A
H
Y
T
A
YSYI
E
P
F
V
Q
N
I
A
G
F
S
AN
F
A
TA
L
LLL
L
G
G
A
GI
IG
S
V
I
F
GKL
GN
Q
Y
ASALVS
T
AIA
L
LLV
C
LA
L
L
-
L
--
P
A
A
NS
E
IHLG
V
L
---
SIF
WG
I
A
M
MI
I
GL
GM
Q
V
K
VL
AL
A
PD
A
TD
V
AM
A
LFS
G
I
FN
I
G
I
G
A
GA
LV
G
N
Q
V
-
S
-
L
HW
S
M
S
M
I
GYV
GA
V
PA
FAAL
I
W
S
II
I
F
R
R
WPV
TL
fig|585057.4.peg.1900
Escherichia coli IAI39 (15-391/396)
V
V
T
LA
V
A
AF
I
F
N
TTEF
V
P
V
GLL
SD
IA
QS
F
H
M
QTAQV
G
I
M
LT
I
YA
W
V
V
A
LMSL
PFM
L
MT
S
QVE
RR
KL
LI
C
L
F
V
V
F
IA
SH
VLS
F
LS
W
S
F
TV
L
V
ISRI
GVA
F
A
H
AI
F
WS
I
T
A
S
L
A
IR
M
A
P
A
GK
R
A
Q
A
LS
L
I
AT
G
T
A
LA
M
VLG
L
PLG
R
I
V
GQ
Y
FGWRMTF
F
AI
G
IGA
L
I
T
L
L
C
L
IKL
LP
LLPS
E
H
S
G
S
L
-
K
SLPLL
F
RRPA
LM
SI
Y
L
L
TV
V
V
VT
A
H
Y
T
A
YSYI
E
P
F
V
Q
N
I
A
G
F
S
AN
F
A
TA
L
LLL
L
G
G
A
GI
IG
S
V
I
F
GKL
GN
Q
Y
ASALVS
T
AIA
L
LLV
C
LA
L
L
-
L
--
P
A
A
NS
E
IHLG
V
L
---
SIF
WG
I
A
M
MI
I
GL
GM
Q
V
K
VL
AL
A
PD
A
TD
V
AM
A
LFS
G
I
FN
I
G
I
G
A
GA
LV
G
N
Q
V
-
S
-
L
HW
S
M
S
M
I
GYV
GA
V
PA
FAAL
I
W
S
II
I
F
R
R
WPV
TL
fig|585057.6.peg.1898
Escherichia coli IAI39 (15-391/396)
V
V
T
LA
V
A
AF
I
F
N
TTEF
V
P
V
GLL
SD
IA
QS
F
H
M
QTAQV
G
I
M
LT
I
YA
W
V
V
A
LMSL
PFM
L
MT
S
QVE
RR
KL
LI
C
L
F
V
V
F
IA
SH
VLS
F
LS
W
S
F
TV
L
V
ISRI
GVA
F
A
H
AI
F
WS
I
T
A
S
L
A
IR
M
A
P
A
GK
R
A
Q
A
LS
L
I
AT
G
T
A
LA
M
VLG
L
PLG
R
I
V
GQ
Y
FGWRMTF
F
AI
G
IGA
L
I
T
L
L
C
L
IKL
LP
LLPS
E
H
S
G
S
L
-
K
SLPLL
F
RRPA
LM
SI
Y
L
L
TV
V
V
VT
A
H
Y
T
A
YSYI
E
P
F
V
Q
N
I
A
G
F
S
AN
F
A
TA
L
LLL
L
G
G
A
GI
IG
S
V
I
F
GKL
GN
Q
Y
ASALVS
T
AIA
L
LLV
C
LA
L
L
-
L
--
P
A
A
NS
E
IHLG
V
L
---
SIF
WG
I
A
M
MI
I
GL
GM
Q
V
K
VL
AL
A
PD
A
TD
V
AM
A
LFS
G
I
FN
I
G
I
G
A
GA
LV
G
N
Q
V
-
S
-
L
HW
S
M
S
M
I
GYV
GA
V
PA
FAAL
I
W
S
II
I
F
R
R
WPV
TL
fig|83333.1.peg.1515
Escherichia coli K12 (15-391/396)
V
V
T
LA
V
A
AF
I
F
N
TTEF
V
P
V
GLL
SD
IA
QS
F
H
M
QTAQV
G
I
M
LT
I
YA
W
V
V
A
LMSL
PFM
L
MT
S
QVE
RR
KL
LI
C
L
F
V
V
F
IA
SH
VLS
F
LS
W
S
F
TV
L
V
ISRI
GVA
F
A
H
AI
F
WS
I
T
A
S
L
A
IR
M
A
P
A
GK
R
A
Q
A
LS
L
I
AT
G
T
A
LA
M
VLG
L
PLG
R
I
V
GQ
Y
FGWRMTF
F
AI
G
IGA
L
I
T
L
L
C
L
IKL
LP
LLPS
E
H
S
G
S
L
-
K
SLPLL
F
RRPA
LM
SI
Y
L
L
TV
V
V
VT
A
H
Y
T
A
YSYI
E
P
F
V
Q
N
I
A
G
F
S
AN
F
A
TA
L
LLL
L
G
G
A
GI
IG
S
V
I
F
GKL
GN
Q
Y
ASALVS
T
AIA
L
LLV
C
LA
L
L
-
L
--
P
A
A
NS
E
IHLG
V
L
---
SIF
WG
I
A
M
MI
I
GL
GM
Q
V
K
VL
AL
A
PD
A
TD
V
AM
A
LFS
G
I
FN
I
G
I
G
A
GA
LV
G
N
Q
V
-
S
-
L
HW
S
M
S
M
I
GYV
GA
V
PA
FAAL
I
W
S
II
I
F
R
R
WPV
TL
fig|595495.4.peg.3443
Escherichia coli KO11 (15-391/396)
V
V
T
LA
V
A
AF
I
F
N
TTEF
V
P
V
GLL
SD
IA
QS
F
H
M
QTAQV
G
I
M
LT
I
YA
W
V
V
A
LMSL
PFM
L
MT
S
QVE
RR
KL
LI
C
L
F
V
V
F
IA
SH
VLS
F
LS
W
S
F
TV
L
V
ISRI
GVA
F
A
H
AI
F
WS
I
T
A
S
L
A
IR
M
A
P
A
GK
R
A
Q
A
LS
L
I
AT
G
T
A
LA
M
VLG
L
PLG
R
I
V
GQ
Y
FGWRMTF
F
AI
G
IGA
L
I
T
L
L
C
L
IKL
LP
LLPS
E
H
S
G
S
L
-
K
SLPLL
F
RRPA
LM
SI
Y
L
L
TV
V
V
VT
A
H
Y
T
A
YSYI
E
P
F
V
Q
N
I
A
G
F
S
AN
F
A
TA
L
LLL
L
G
G
A
GI
IG
S
V
I
F
GKL
GN
Q
Y
ASALVS
T
AIA
L
LLV
C
LA
L
L
-
L
--
P
A
A
NS
E
IHLG
V
L
---
SIF
WG
I
A
M
MI
I
GL
GM
Q
V
K
VL
AL
A
PD
A
TD
V
AM
A
LFS
G
I
FN
I
G
I
G
A
GA
LV
G
N
Q
V
-
S
-
L
HW
S
M
S
M
I
GYV
GA
V
PA
FAAL
I
W
S
II
I
F
R
R
WPV
TL
fig|679207.4.peg.4438
Escherichia coli MS 107-1 (15-391/396)
V
V
T
LA
V
A
AF
I
F
N
TTEF
V
P
V
GLL
SD
IA
QS
F
H
M
QTAQV
G
I
M
LT
I
YA
W
V
V
A
LMSL
PFM
L
MT
S
QVE
RR
KL
LI
C
L
F
V
V
F
IA
SH
VLS
F
LS
W
S
F
TV
L
V
ISRI
GVA
F
A
H
AI
F
WS
I
T
A
S
L
A
IR
M
A
P
A
GK
R
A
Q
A
LS
L
I
AT
G
T
A
LA
M
VLG
L
PLG
R
I
V
GQ
Y
FGWRMTF
F
AI
G
IGA
L
I
T
L
L
C
L
IKL
LP
LLPS
E
H
S
G
S
L
-
K
SLPLL
F
RRPA
LM
SI
Y
L
L
TV
V
V
VT
A
H
Y
T
A
YSYI
E
P
F
V
Q
N
I
A
G
F
S
AN
F
A
TA
L
LLL
L
G
G
A
GI
IG
S
V
I
F
GKL
GN
Q
Y
ASALVS
T
AIA
L
LLV
C
LA
L
L
-
L
--
P
A
A
NS
E
IHLG
V
L
---
SIF
WG
I
A
M
MI
I
GL
GM
Q
V
K
VL
AL
A
PD
A
TD
V
AM
A
LFS
G
I
FN
I
G
I
G
A
GA
LV
G
N
Q
V
-
S
-
L
HW
S
M
S
M
I
GYV
GA
V
PA
FAAL
I
W
S
II
I
F
R
R
WPV
TL
fig|749537.3.peg.1542
Escherichia coli MS 115-1 (15-391/396)
V
V
T
LA
V
A
AF
I
F
N
TTEF
V
P
V
GLL
SD
IA
QS
F
H
M
QTAQV
G
I
M
LT
I
YA
W
V
V
A
LMSL
PFM
L
MT
S
QVE
RR
KL
LI
C
L
F
V
V
F
IA
SH
VLS
F
LS
W
S
F
TV
L
V
ISRI
GVA
F
A
H
AI
F
WS
I
T
A
S
L
A
IR
M
A
P
A
GK
R
A
Q
A
LS
L
I
AT
G
T
A
LA
M
VLG
L
PLG
R
I
V
GQ
Y
FGWRMTF
F
AI
G
IGA
L
I
T
L
L
C
L
IKL
LP
LLPS
E
H
S
G
S
L
-
K
SLPLL
F
RRPA
LM
SI
Y
L
L
TV
V
V
VT
A
H
Y
T
A
YSYI
E
P
F
V
Q
N
I
A
G
F
S
AN
F
A
TA
L
LLL
L
G
G
A
GI
IG
S
V
I
F
GKL
GN
Q
Y
ASALVS
T
AIA
L
LLV
C
LA
L
L
-
L
--
P
A
A
NS
E
IHLG
V
L
---
SIF
WG
I
A
M
MI
I
GL
GM
Q
V
K
VL
AL
A
PD
A
TD
V
AM
A
LFS
G
I
FN
I
G
I
G
A
GA
LV
G
N
Q
V
-
S
-
L
HW
S
M
S
M
I
GYV
GA
V
PA
FAAL
I
W
S
II
I
F
R
R
WPV
TL
fig|679205.4.peg.4313
Escherichia coli MS 124-1 (15-391/396)
V
V
T
LA
V
A
AF
I
F
N
TTEF
V
P
V
GLL
SD
IA
QS
F
H
M
QTAQV
G
I
M
LT
I
YA
W
V
V
A
LMSL
PFM
L
MT
S
QVE
RR
KL
LI
C
L
F
V
V
F
IA
SH
VLS
F
LS
W
S
F
TV
L
V
ISRI
GVA
F
A
H
AI
F
WS
I
T
A
S
L
A
IR
M
A
P
A
GK
R
A
Q
A
LS
L
I
AT
G
T
A
LA
M
VLG
L
PLG
R
I
V
GQ
Y
FGWRMTF
F
AI
G
IGA
L
I
T
L
L
C
L
IKL
LP
LLPS
E
H
S
G
S
L
-
K
SLPLL
F
RRPA
LM
SI
Y
L
L
TV
V
V
VT
A
H
Y
T
A
YSYI
E
P
F
V
Q
N
I
A
G
F
S
AN
F
A
TA
L
LLL
L
G
G
A
GI
IG
S
V
I
F
GKL
GN
Q
Y
ASALVS
T
AIA
L
LLV
C
LA
L
L
-
L
--
P
A
A
NS
E
IHLG
V
L
---
SIF
WG
I
A
M
MI
I
GL
GM
Q
V
K
VL
AL
A
PD
A
TD
V
AM
A
LFS
G
I
FN
I
G
I
G
A
GA
LV
G
N
Q
V
-
S
-
L
HW
S
M
S
M
I
GYV
GA
V
PA
FAAL
I
W
S
II
I
F
R
R
WPV
TL
fig|749540.3.peg.1263
Escherichia coli MS 146-1 (15-391/396)
V
V
T
LA
V
A
AF
I
F
N
TTEF
V
P
V
GLL
SD
IA
QS
F
H
M
QTAQV
G
I
M
LT
I
YA
W
V
V
A
LMSL
PFM
L
MT
S
QVE
RR
KL
LI
C
L
F
V
V
F
IA
SH
VLS
F
LS
W
S
F
TV
L
V
ISRI
GVA
F
A
H
AI
F
WS
I
T
A
S
L
A
IR
M
A
P
A
GK
R
A
Q
A
LS
L
I
AT
G
T
A
LA
M
VLG
L
PLG
R
I
V
GQ
Y
FGWRMTF
F
AI
G
IGA
L
I
T
L
L
C
L
IKL
LP
LLPS
E
H
S
G
S
L
-
K
SLPLL
F
RRPA
LM
SI
Y
L
L
TV
V
V
VT
A
H
Y
T
A
YSYI
E
P
F
V
Q
N
I
A
G
F
S
AN
F
A
TA
L
LLL
L
G
G
A
GI
IG
S
V
I
F
GKL
GN
Q
Y
ASALVS
T
AIA
L
LLV
C
LA
L
L
-
L
--
P
A
A
NS
E
IHLG
V
L
---
SIF
WG
I
A
M
MI
I
GL
GM
Q
V
K
VL
AL
A
PD
A
TD
V
AM
A
LFS
G
I
FN
I
G
I
G
A
GA
LV
G
N
Q
V
-
S
-
L
HW
S
M
S
M
I
GYV
GA
V
PA
FAAL
I
W
S
II
I
F
R
R
WPV
TL
fig|749547.3.peg.1313
Escherichia coli MS 187-1 (15-391/396)
V
V
T
LA
V
A
AF
I
F
N
TTEF
V
P
V
GLL
SD
IA
QS
F
H
M
QTAQV
G
I
M
LT
I
YA
W
V
V
A
LMSL
PFM
L
MT
S
QVE
RR
KL
LI
C
L
F
V
V
F
IA
SH
VLS
F
LS
W
S
F
TV
L
V
ISRI
GVA
F
A
H
AI
F
WS
I
T
A
S
L
A
IR
M
A
P
A
GK
R
A
Q
A
LS
L
I
AT
G
T
A
LA
M
VLG
L
PLG
R
I
V
GQ
Y
FGWRMTF
F
AI
G
IGA
L
I
T
L
L
C
L
IKL
LP
LLPS
E
H
S
G
S
L
-
K
SLPLL
F
RRPA
LM
SI
Y
L
L
TV
V
V
VT
A
H
Y
T
A
YSYI
E
P
F
V
Q
N
I
A
G
F
S
AN
F
A
TA
L
LLL
L
G
G
A
GI
IG
S
V
I
F
GKL
GN
Q
Y
ASALVS
T
AIA
L
LLV
C
LA
L
L
-
L
--
P
A
A
NS
E
IHLG
V
L
---
SIF
WG
I
A
M
MI
I
GL
GM
Q
V
K
VL
AL
A
PD
A
TD
V
AM
A
LFS
G
I
FN
I
G
I
G
A
GA
LV
G
N
Q
V
-
S
-
L
HW
S
M
S
M
I
GYV
GA
V
PA
FAAL
I
W
S
II
I
F
R
R
WPV
TL
fig|749531.3.peg.736
Escherichia coli MS 69-1 (15-391/396)
V
V
T
LA
V
A
AF
I
F
N
TTEF
V
P
V
GLL
SD
IA
QS
F
H
M
QTAQV
G
I
M
LT
I
YA
W
V
V
A
LMSL
PFM
L
MT
S
QVE
RR
KL
LI
C
L
F
V
V
F
IA
SH
VLS
F
LS
W
S
F
TV
L
V
ISRI
GVA
F
A
H
AI
F
WS
I
T
A
S
L
A
IR
M
A
P
A
GK
R
A
Q
A
LS
L
I
AT
G
T
A
LA
M
VLG
L
PLG
R
I
V
GQ
Y
FGWRMTF
F
AI
G
IGA
L
I
T
L
L
C
L
IKL
LP
LLPS
E
H
S
G
S
L
-
K
SLPLL
F
RRPA
LM
SI
Y
L
L
TV
V
V
VT
A
H
Y
T
A
YSYI
E
P
F
V
Q
N
I
A
G
F
S
AN
F
A
TA
L
LLL
L
G
G
A
GI
IG
S
V
I
F
GKL
GN
Q
Y
ASALVS
T
AIA
L
LLV
C
LA
L
L
-
L
--
P
A
A
NS
E
IHLG
V
L
---
SIF
WG
I
A
M
MI
I
GL
GM
Q
V
K
VL
AL
A
PD
A
TD
V
AM
A
LFS
G
I
FN
I
G
I
G
A
GA
LV
G
N
Q
V
-
S
-
L
HW
S
M
S
M
I
GYV
GA
V
PA
FAAL
I
W
S
II
I
F
R
R
WPV
TL
fig|749533.3.peg.1845
Escherichia coli MS 84-1 (15-391/396)
V
V
T
LA
V
A
AF
I
F
N
TTEF
V
P
V
GLL
SD
IA
QS
F
H
M
QTAQV
G
I
M
LT
I
YA
W
V
V
A
LMSL
PFM
L
MT
S
QVE
RR
KL
LI
C
L
F
V
V
F
IA
SH
VLS
F
LS
W
S
F
TV
L
V
ISRI
GVA
F
A
H
AI
F
WS
I
T
A
S
L
A
IR
M
A
P
A
GK
R
A
Q
A
LS
L
I
AT
G
T
A
LA
M
VLG
L
PLG
R
I
V
GQ
Y
FGWRMTF
F
AI
G
IGA
L
I
T
L
L
C
L
IKL
LP
LLPS
E
H
S
G
S
L
-
K
SLPLL
F
RRPA
LM
SI
Y
L
L
TV
V
V
VT
A
H
Y
T
A
YSYI
E
P
F
V
Q
N
I
A
G
F
S
AN
F
A
TA
L
LLL
L
G
G
A
GI
IG
S
V
I
F
GKL
GN
Q
Y
ASALVS
T
AIA
L
LLV
C
LA
L
L
-
L
--
P
A
A
NS
E
IHLG
V
L
---
SIF
WG
I
A
M
MI
I
GL
GM
Q
V
K
VL
AL
A
PD
A
TD
V
AM
A
LFS
G
I
FN
I
G
I
G
A
GA
LV
G
N
Q
V
-
S
-
L
HW
S
M
S
M
I
GYV
GA
V
PA
FAAL
I
W
S
II
I
F
R
R
WPV
TL
fig|585396.4.peg.2004
Escherichia coli O111:H- str. 11128 (15-391/396)
V
V
T
LA
V
A
AF
I
F
N
TTEF
V
P
V
GLL
SD
IA
QS
F
H
M
QTAQV
G
I
M
LT
I
YA
W
V
V
A
LMSL
PFM
L
MT
S
QVE
RR
KL
LI
C
L
F
V
V
F
IA
SH
VLS
F
LS
W
S
F
TV
L
V
ISRI
GVA
F
A
H
AI
F
WS
I
T
A
S
L
A
IR
M
A
P
A
GK
R
A
Q
A
LS
L
I
AT
G
T
A
LA
M
VLG
L
PLG
R
I
V
GQ
Y
FGWRMTF
F
AI
G
IGA
L
I
T
L
L
C
L
IKL
LP
LLPS
E
H
S
G
S
L
-
K
SLPLL
F
RRPA
LM
SI
Y
L
L
TV
V
V
VT
A
H
Y
T
A
YSYI
E
P
F
V
Q
N
I
A
G
F
S
AN
F
A
TA
L
LLL
L
G
G
A
GI
IG
S
V
I
F
GKL
GN
Q
Y
ASALVS
T
AIA
L
LLV
C
LA
L
L
-
L
--
P
A
A
NS
E
IHLG
V
L
---
SIF
WG
I
A
M
MI
I
GL
GM
Q
V
K
VL
AL
A
PD
A
TD
V
AM
A
LFS
G
I
FN
I
G
I
G
A
GA
LV
G
N
Q
V
-
S
-
L
HW
S
M
S
M
I
GYV
GA
V
PA
FAAL
I
W
S
II
I
F
R
R
WPV
TL
fig|573235.3.peg.2165
Escherichia coli O26:H11 str. 11368 (15-391/396)
V
V
T
LA
V
A
AF
I
F
N
TTEF
V
P
V
GLL
SD
IA
QS
F
H
M
QTAQV
G
I
M
LT
I
YA
W
V
V
A
LMSL
PFM
L
MT
S
QVE
RR
KL
LI
C
L
F
V
V
F
IA
SH
VLS
F
LS
W
S
F
TV
L
V
ISRI
GVA
F
A
H
AI
F
WS
I
T
A
S
L
A
IR
M
A
P
A
GK
R
A
Q
A
LS
L
I
AT
G
T
A
LA
M
VLG
L
PLG
R
I
V
GQ
Y
FGWRMTF
F
AI
G
IGA
L
I
T
L
L
C
L
IKL
LP
LLPS
E
H
S
G
S
L
-
K
SLPLL
F
RRPA
LM
SI
Y
L
L
TV
V
V
VT
A
H
Y
T
A
YSYI
E
P
F
V
Q
N
I
A
G
F
S
AN
F
A
TA
L
LLL
L
G
G
A
GI
IG
S
V
I
F
GKL
GN
Q
Y
ASALVS
T
AIA
L
LLV
C
LA
L
L
-
L
--
P
A
A
NS
E
IHLG
V
L
---
SIF
WG
I
A
M
MI
I
GL
GM
Q
V
K
VL
AL
A
PD
A
TD
V
AM
A
LFS
G
I
FN
I
G
I
G
A
GA
LV
G
N
Q
V
-
S
-
L
HW
S
M
S
M
I
GYV
GA
V
PA
FAAL
I
W
S
II
I
F
R
R
WPV
TL
fig|409438.11.peg.1758
Escherichia coli SE11 (15-391/396)
V
V
T
LA
V
A
AF
I
F
N
TTEF
V
P
V
GLL
SD
IA
QS
F
H
M
QTAQV
G
I
M
LT
I
YA
W
V
V
A
LMSL
PFM
L
MT
S
QVE
RR
KL
LI
C
L
F
V
V
F
IA
SH
VLS
F
LS
W
S
F
TV
L
V
ISRI
GVA
F
A
H
AI
F
WS
I
T
A
S
L
A
IR
M
A
P
A
GK
R
A
Q
A
LS
L
I
AT
G
T
A
LA
M
VLG
L
PLG
R
I
V
GQ
Y
FGWRMTF
F
AI
G
IGA
L
I
T
L
L
C
L
IKL
LP
LLPS
E
H
S
G
S
L
-
K
SLPLL
F
RRPA
LM
SI
Y
L
L
TV
V
V
VT
A
H
Y
T
A
YSYI
E
P
F
V
Q
N
I
A
G
F
S
AN
F
A
TA
L
LLL
L
G
G
A
GI
IG
S
V
I
F
GKL
GN
Q
Y
ASALVS
T
AIA
L
LLV
C
LA
L
L
-
L
--
P
A
A
NS
E
IHLG
V
L
---
SIF
WG
I
A
M
MI
I
GL
GM
Q
V
K
VL
AL
A
PD
A
TD
V
AM
A
LFS
G
I
FN
I
G
I
G
A
GA
LV
G
N
Q
V
-
S
-
L
HW
S
M
S
M
I
GYV
GA
V
PA
FAAL
I
W
S
II
I
F
R
R
WPV
TL
fig|566546.4.peg.1649
Escherichia coli W (15-391/396)
V
V
T
LA
V
A
AF
I
F
N
TTEF
V
P
V
GLL
SD
IA
QS
F
H
M
QTAQV
G
I
M
LT
I
YA
W
V
V
A
LMSL
PFM
L
MT
S
QVE
RR
KL
LI
C
L
F
V
V
F
IA
SH
VLS
F
LS
W
S
F
TV
L
V
ISRI
GVA
F
A
H
AI
F
WS
I
T
A
S
L
A
IR
M
A
P
A
GK
R
A
Q
A
LS
L
I
AT
G
T
A
LA
M
VLG
L
PLG
R
I
V
GQ
Y
FGWRMTF
F
AI
G
IGA
L
I
T
L
L
C
L
IKL
LP
LLPS
E
H
S
G
S
L
-
K
SLPLL
F
RRPA
LM
SI
Y
L
L
TV
V
V
VT
A
H
Y
T
A
YSYI
E
P
F
V
Q
N
I
A
G
F
S
AN
F
A
TA
L
LLL
L
G
G
A
GI
IG
S
V
I
F
GKL
GN
Q
Y
ASALVS
T
AIA
L
LLV
C
LA
L
L
-
L
--
P
A
A
NS
E
IHLG
V
L
---
SIF
WG
I
A
M
MI
I
GL
GM
Q
V
K
VL
AL
A
PD
A
TD
V
AM
A
LFS
G
I
FN
I
G
I
G
A
GA
LV
G
N
Q
V
-
S
-
L
HW
S
M
S
M
I
GYV
GA
V
PA
FAAL
I
W
S
II
I
F
R
R
WPV
TL
fig|316407.3.peg.1485
Escherichia coli W3110 (15-391/396)
V
V
T
LA
V
A
AF
I
F
N
TTEF
V
P
V
GLL
SD
IA
QS
F
H
M
QTAQV
G
I
M
LT
I
YA
W
V
V
A
LMSL
PFM
L
MT
S
QVE
RR
KL
LI
C
L
F
V
V
F
IA
SH
VLS
F
LS
W
S
F
TV
L
V
ISRI
GVA
F
A
H
AI
F
WS
I
T
A
S
L
A
IR
M
A
P
A
GK
R
A
Q
A
LS
L
I
AT
G
T
A
LA
M
VLG
L
PLG
R
I
V
GQ
Y
FGWRMTF
F
AI
G
IGA
L
I
T
L
L
C
L
IKL
LP
LLPS
E
H
S
G
S
L
-
K
SLPLL
F
RRPA
LM
SI
Y
L
L
TV
V
V
VT
A
H
Y
T
A
YSYI
E
P
F
V
Q
N
I
A
G
F
S
AN
F
A
TA
L
LLL
L
G
G
A
GI
IG
S
V
I
F
GKL
GN
Q
Y
ASALVS
T
AIA
L
LLV
C
LA
L
L
-
L
--
P
A
A
NS
E
IHLG
V
L
---
SIF
WG
I
A
M
MI
I
GL
GM
Q
V
K
VL
AL
A
PD
A
TD
V
AM
A
LFS
G
I
FN
I
G
I
G
A
GA
LV
G
N
Q
V
-
S
-
L
HW
S
M
S
M
I
GYV
GA
V
PA
FAAL
I
W
S
II
I
F
R
R
WPV
TL
fig|316385.5.peg.1641
Escherichia coli str. K-12 substr. DH10B (15-391/396)
V
V
T
LA
V
A
AF
I
F
N
TTEF
V
P
V
GLL
SD
IA
QS
F
H
M
QTAQV
G
I
M
LT
I
YA
W
V
V
A
LMSL
PFM
L
MT
S
QVE
RR
KL
LI
C
L
F
V
V
F
IA
SH
VLS
F
LS
W
S
F
TV
L
V
ISRI
GVA
F
A
H
AI
F
WS
I
T
A
S
L
A
IR
M
A
P
A
GK
R
A
Q
A
LS
L
I
AT
G
T
A
LA
M
VLG
L
PLG
R
I
V
GQ
Y
FGWRMTF
F
AI
G
IGA
L
I
T
L
L
C
L
IKL
LP
LLPS
E
H
S
G
S
L
-
K
SLPLL
F
RRPA
LM
SI
Y
L
L
TV
V
V
VT
A
H
Y
T
A
YSYI
E
P
F
V
Q
N
I
A
G
F
S
AN
F
A
TA
L
LLL
L
G
G
A
GI
IG
S
V
I
F
GKL
GN
Q
Y
ASALVS
T
AIA
L
LLV
C
LA
L
L
-
L
--
P
A
A
NS
E
IHLG
V
L
---
SIF
WG
I
A
M
MI
I
GL
GM
Q
V
K
VL
AL
A
PD
A
TD
V
AM
A
LFS
G
I
FN
I
G
I
G
A
GA
LV
G
N
Q
V
-
S
-
L
HW
S
M
S
M
I
GYV
GA
V
PA
FAAL
I
W
S
II
I
F
R
R
WPV
TL
fig|316385.7.peg.1683
Escherichia coli str. K-12 substr. DH10B (15-391/396)
V
V
T
LA
V
A
AF
I
F
N
TTEF
V
P
V
GLL
SD
IA
QS
F
H
M
QTAQV
G
I
M
LT
I
YA
W
V
V
A
LMSL
PFM
L
MT
S
QVE
RR
KL
LI
C
L
F
V
V
F
IA
SH
VLS
F
LS
W
S
F
TV
L
V
ISRI
GVA
F
A
H
AI
F
WS
I
T
A
S
L
A
IR
M
A
P
A
GK
R
A
Q
A
LS
L
I
AT
G
T
A
LA
M
VLG
L
PLG
R
I
V
GQ
Y
FGWRMTF
F
AI
G
IGA
L
I
T
L
L
C
L
IKL
LP
LLPS
E
H
S
G
S
L
-
K
SLPLL
F
RRPA
LM
SI
Y
L
L
TV
V
V
VT
A
H
Y
T
A
YSYI
E
P
F
V
Q
N
I
A
G
F
S
AN
F
A
TA
L
LLL
L
G
G
A
GI
IG
S
V
I
F
GKL
GN
Q
Y
ASALVS
T
AIA
L
LLV
C
LA
L
L
-
L
--
P
A
A
NS
E
IHLG
V
L
---
SIF
WG
I
A
M
MI
I
GL
GM
Q
V
K
VL
AL
A
PD
A
TD
V
AM
A
LFS
G
I
FN
I
G
I
G
A
GA
LV
G
N
Q
V
-
S
-
L
HW
S
M
S
M
I
GYV
GA
V
PA
FAAL
I
W
S
II
I
F
R
R
WPV
TL
fig|511145.12.peg.1597
Escherichia coli str. K-12 substr. MG1655 (15-391/396)
V
V
T
LA
V
A
AF
I
F
N
TTEF
V
P
V
GLL
SD
IA
QS
F
H
M
QTAQV
G
I
M
LT
I
YA
W
V
V
A
LMSL
PFM
L
MT
S
QVE
RR
KL
LI
C
L
F
V
V
F
IA
SH
VLS
F
LS
W
S
F
TV
L
V
ISRI
GVA
F
A
H
AI
F
WS
I
T
A
S
L
A
IR
M
A
P
A
GK
R
A
Q
A
LS
L
I
AT
G
T
A
LA
M
VLG
L
PLG
R
I
V
GQ
Y
FGWRMTF
F
AI
G
IGA
L
I
T
L
L
C
L
IKL
LP
LLPS
E
H
S
G
S
L
-
K
SLPLL
F
RRPA
LM
SI
Y
L
L
TV
V
V
VT
A
H
Y
T
A
YSYI
E
P
F
V
Q
N
I
A
G
F
S
AN
F
A
TA
L
LLL
L
G
G
A
GI
IG
S
V
I
F
GKL
GN
Q
Y
ASALVS
T
AIA
L
LLV
C
LA
L
L
-
L
--
P
A
A
NS
E
IHLG
V
L
---
SIF
WG
I
A
M
MI
I
GL
GM
Q
V
K
VL
AL
A
PD
A
TD
V
AM
A
LFS
G
I
FN
I
G
I
G
A
GA
LV
G
N
Q
V
-
S
-
L
HW
S
M
S
M
I
GYV
GA
V
PA
FAAL
I
W
S
II
I
F
R
R
WPV
TL
fig|511145.6.peg.1582
Escherichia coli str. K-12 substr. MG1655 (15-391/396)
V
V
T
LA
V
A
AF
I
F
N
TTEF
V
P
V
GLL
SD
IA
QS
F
H
M
QTAQV
G
I
M
LT
I
YA
W
V
V
A
LMSL
PFM
L
MT
S
QVE
RR
KL
LI
C
L
F
V
V
F
IA
SH
VLS
F
LS
W
S
F
TV
L
V
ISRI
GVA
F
A
H
AI
F
WS
I
T
A
S
L
A
IR
M
A
P
A
GK
R
A
Q
A
LS
L
I
AT
G
T
A
LA
M
VLG
L
PLG
R
I
V
GQ
Y
FGWRMTF
F
AI
G
IGA
L
I
T
L
L
C
L
IKL
LP
LLPS
E
H
S
G
S
L
-
K
SLPLL
F
RRPA
LM
SI
Y
L
L
TV
V
V
VT
A
H
Y
T
A
YSYI
E
P
F
V
Q
N
I
A
G
F
S
AN
F
A
TA
L
LLL
L
G
G
A
GI
IG
S
V
I
F
GKL
GN
Q
Y
ASALVS
T
AIA
L
LLV
C
LA
L
L
-
L
--
P
A
A
NS
E
IHLG
V
L
---
SIF
WG
I
A
M
MI
I
GL
GM
Q
V
K
VL
AL
A
PD
A
TD
V
AM
A
LFS
G
I
FN
I
G
I
G
A
GA
LV
G
N
Q
V
-
S
-
L
HW
S
M
S
M
I
GYV
GA
V
PA
FAAL
I
W
S
II
I
F
R
R
WPV
TL
fig|749527.3.peg.4600
Escherichia coli MS 21-1 (15-391/396)
V
V
T
LA
V
A
AF
I
F
N
TTEF
V
P
V
GLL
SD
IA
QS
F
H
M
QTAQV
G
I
M
LT
I
YA
W
V
V
A
LMSL
PFM
L
MT
S
QVE
RR
KL
LI
C
L
F
V
V
F
IA
SH
VLS
F
LS
W
S
F
TV
L
V
ISRI
GVA
F
A
H
AI
F
WS
I
T
A
S
L
A
IR
M
A
P
A
GK
R
A
Q
A
LS
L
I
AT
G
T
A
LA
M
VLG
L
PLG
R
I
V
GQ
Y
FGWRMTF
F
AI
G
IGA
L
I
T
L
L
C
L
IKL
LP
LLPS
E
H
S
G
S
L
-
K
SLPLL
F
RRPA
LM
SI
Y
L
L
TV
V
V
VT
A
H
Y
T
A
YSYI
E
P
F
V
Q
N
I
A
G
F
S
AN
F
A
TA
L
LLL
L
G
G
A
GI
IG
S
V
I
F
GKL
GN
Q
Y
ASTLVS
T
AIA
L
LLV
C
LA
L
L
-
L
--
P
A
A
NS
E
IHLG
V
L
---
SIF
WG
I
A
M
MI
I
GL
GM
Q
V
K
VL
AL
A
PD
A
TD
V
AM
A
LFS
G
I
FN
I
G
I
G
A
GA
LV
G
N
Q
V
-
S
-
L
HW
S
M
S
I
I
GYV
GA
V
PA
FAAL
I
W
S
II
I
F
R
R
WPV
TL
fig|216592.1.peg.2075
Escherichia coli 042 (15-391/396)
V
V
T
LA
V
A
AF
I
F
N
TTEF
V
P
V
GLL
SD
IA
QS
F
H
M
QTAQV
G
I
M
LT
I
YA
W
V
V
A
LMSL
PFM
L
MT
S
QVE
RR
KL
LI
C
L
F
V
V
F
IA
SH
VLS
F
LS
W
S
F
TV
L
V
ISRI
GVA
F
A
H
AI
F
WS
I
T
A
S
L
A
IR
M
A
P
A
GK
R
A
Q
A
LS
L
I
AT
G
T
A
LA
M
VLG
L
PLG
R
I
V
GQ
Y
FGWRMTF
F
AI
G
IGA
F
I
T
L
L
C
L
IKL
LP
LLPS
E
H
S
G
S
L
-
K
SLPLL
F
RRPA
LM
SI
Y
L
L
TV
V
V
VT
A
H
Y
T
A
YSYI
E
P
F
V
Q
N
I
A
G
F
S
AN
F
A
TA
L
LLL
L
G
G
A
GI
IG
S
V
I
F
GKL
GN
Q
Y
ASALVS
T
AIA
L
LLV
C
LA
L
L
-
L
--
P
A
A
NS
E
IHLG
V
L
---
SIF
WG
I
A
M
MI
I
GL
GM
Q
V
K
VL
AL
A
PD
A
TD
V
AM
A
LFS
G
I
FN
I
G
I
G
A
GA
LV
G
N
Q
V
-
S
-
L
HW
S
M
S
M
I
GYV
GA
V
PA
FAAL
I
W
S
II
I
F
R
R
WPV
TL
fig|216592.3.peg.1719
Escherichia coli 042 (15-391/396)
V
V
T
LA
V
A
AF
I
F
N
TTEF
V
P
V
GLL
SD
IA
QS
F
H
M
QTAQV
G
I
M
LT
I
YA
W
V
V
A
LMSL
PFM
L
MT
S
QVE
RR
KL
LI
C
L
F
V
V
F
IA
SH
VLS
F
LS
W
S
F
TV
L
V
ISRI
GVA
F
A
H
AI
F
WS
I
T
A
S
L
A
IR
M
A
P
A
GK
R
A
Q
A
LS
L
I
AT
G
T
A
LA
M
VLG
L
PLG
R
I
V
GQ
Y
FGWRMTF
F
AI
G
IGA
F
I
T
L
L
C
L
IKL
LP
LLPS
E
H
S
G
S
L
-
K
SLPLL
F
RRPA
LM
SI
Y
L
L
TV
V
V
VT
A
H
Y
T
A
YSYI
E
P
F
V
Q
N
I
A
G
F
S
AN
F
A
TA
L
LLL
L
G
G
A
GI
IG
S
V
I
F
GKL
GN
Q
Y
ASALVS
T
AIA
L
LLV
C
LA
L
L
-
L
--
P
A
A
NS
E
IHLG
V
L
---
SIF
WG
I
A
M
MI
I
GL
GM
Q
V
K
VL
AL
A
PD
A
TD
V
AM
A
LFS
G
I
FN
I
G
I
G
A
GA
LV
G
N
Q
V
-
S
-
L
HW
S
M
S
M
I
GYV
GA
V
PA
FAAL
I
W
S
II
I
F
R
R
WPV
TL
fig|550677.3.peg.2944
Escherichia coli B354 (15-391/396)
V
V
T
LA
V
A
AF
I
F
N
TTEF
V
P
V
GLL
SD
IA
QS
F
H
M
QTAQV
G
I
M
LT
I
YA
W
V
V
A
LMSL
PFM
L
MT
S
QVE
RR
KL
LI
C
L
F
V
V
F
IA
SH
VLS
F
LS
W
S
F
TV
L
V
ISRI
GVA
F
A
H
AI
F
WS
I
T
A
S
L
A
IR
M
A
P
A
GK
R
A
Q
A
LS
L
I
AT
G
T
A
LA
M
VLG
L
PLG
R
I
V
GQ
Y
FGWRMTF
F
AI
G
IGA
F
I
T
L
L
C
L
IKL
LP
LLPS
E
H
S
G
S
L
-
K
SLPLL
F
RRPA
LM
SI
Y
L
L
TV
V
V
VT
A
H
Y
T
A
YSYI
E
P
F
V
Q
N
I
A
G
F
S
AN
F
A
TA
L
LLL
L
G
G
A
GI
IG
S
V
I
F
GKL
GN
Q
Y
ASALVS
T
AIA
L
LLV
C
LA
L
L
-
L
--
S
A
A
NS
E
IHLG
V
L
---
SIF
WG
I
A
M
MI
I
GL
GM
Q
V
K
VL
AL
A
PD
A
TD
V
AM
A
LFS
G
I
FN
I
G
I
G
A
GA
LV
G
N
Q
V
-
S
-
L
HW
S
M
S
M
I
GYV
GA
V
PA
FAAL
I
W
S
II
I
F
R
R
WPV
TL
fig|656379.3.peg.3583
Escherichia coli FVEC1302 (15-391/396)
V
V
T
LA
V
A
AF
I
F
N
TTEF
V
P
V
GLL
SD
IA
QS
F
H
M
QTAQV
G
I
M
LT
I
YA
W
V
V
A
LMSL
PFM
L
MT
S
QVE
RR
KL
LI
C
L
F
V
V
F
IA
SH
VLS
F
LS
W
S
F
TV
L
V
ISRI
GVA
F
A
H
AI
F
WS
I
T
A
S
L
A
IR
M
A
P
A
GK
R
A
Q
A
LS
L
I
AT
G
T
A
LA
M
VLG
L
PLG
R
I
V
GQ
Y
FGWRMTF
F
AI
G
IGA
F
I
T
L
L
C
L
IKL
LP
LLPS
E
H
S
G
S
L
-
K
SLPLL
F
RRPA
LM
SI
Y
L
L
TV
V
V
VT
A
H
Y
T
A
YSYI
E
P
F
V
Q
N
I
A
G
F
S
AN
F
A
TA
L
LLL
L
G
G
A
GI
IG
S
V
I
F
GKL
GN
Q
Y
ASALVS
T
AIA
L
LLV
C
LA
L
L
-
L
--
P
A
A
NS
E
IHLG
V
L
---
SIF
WG
I
A
M
MI
I
GL
GM
Q
V
K
VL
AL
A
PD
A
TD
V
AM
A
LFS
G
I
FN
I
G
I
G
A
GA
LV
G
N
Q
V
-
S
-
L
HW
S
M
S
M
I
GYV
GA
V
PA
FAAL
I
W
S
II
I
F
R
R
WPV
TL
fig|656380.3.peg.2933
Escherichia coli FVEC1412 (15-391/396)
V
V
T
LA
V
A
AF
I
F
N
TTEF
V
P
V
GLL
SD
IA
QS
F
H
M
QTAQV
G
I
M
LT
I
YA
W
V
V
A
LMSL
PFM
L
MT
S
QVE
RR
KL
LI
C
L
F
V
V
F
IA
SH
VLS
F
LS
W
S
F
TV
L
V
ISRI
GVA
F
A
H
AI
F
WS
I
T
A
S
L
A
IR
M
A
P
A
GK
R
A
Q
A
LS
L
I
AT
G
T
A
LA
M
VLG
L
PLG
R
I
V
GQ
Y
FGWRMTF
F
AI
G
IGA
F
I
T
L
L
C
L
IKL
LP
LLPS
E
H
S
G
S
L
-
K
SLPLL
F
RRPA
LM
SI
Y
L
L
TV
V
V
VT
A
H
Y
T
A
YSYI
E
P
F
V
Q
N
I
A
G
F
S
AN
F
A
TA
L
LLL
L
G
G
A
GI
IG
S
V
I
F
GKL
GN
Q
Y
ASALVS
T
AIA
L
LLV
C
LA
L
L
-
L
--
P
A
A
NS
E
IHLG
V
L
---
SIF
WG
I
A
M
MI
I
GL
GM
Q
V
K
VL
AL
A
PD
A
TD
V
AM
A
LFS
G
I
FN
I
G
I
G
A
GA
LV
G
N
Q
V
-
S
-
L
HW
S
M
S
M
I
GYV
GA
V
PA
FAAL
I
W
S
II
I
F
R
R
WPV
TL
fig|656414.3.peg.1826
Escherichia coli H736 (15-391/396)
V
V
T
LA
V
A
AF
I
F
N
TTEF
V
P
V
GLL
SD
IA
QS
F
H
M
QTAQV
G
I
M
LT
I
YA
W
V
V
A
LMSL
PFM
L
MT
S
QVE
RR
KL
LI
C
L
F
V
V
F
IA
SH
VLS
F
LS
W
S
F
TV
L
V
ISRI
GVA
F
A
H
AI
F
WS
I
T
A
S
L
A
IR
M
A
P
A
GK
R
A
Q
A
LS
L
I
AT
G
T
A
LA
M
VLG
L
PLG
R
I
V
GQ
Y
FGWRMTF
F
AI
G
IGA
L
I
T
L
L
C
L
IKL
LP
LLPS
E
H
S
G
S
L
-
K
SLPLF
F
RRPA
LM
SI
Y
L
L
TV
V
V
VT
A
H
Y
T
A
YSYI
E
P
F
V
Q
N
I
A
G
F
S
AN
F
A
TA
L
LLL
L
G
G
A
GI
IG
S
V
I
F
GKL
GN
Q
Y
ASALVS
T
AIA
L
LLV
C
LA
L
L
-
L
--
P
A
A
NS
E
IHLG
V
L
---
SIF
WG
I
A
M
MI
I
GL
GM
Q
V
K
VL
AL
A
PD
A
TD
V
AM
A
LFS
G
I
FN
I
G
I
G
A
GA
LV
G
N
Q
V
-
S
-
L
HW
S
M
S
M
I
GYV
GA
V
PA
FAAL
I
W
S
II
I
F
R
R
WPV
TL
fig|749549.3.peg.1905
Escherichia coli MS 198-1 (15-391/396)
V
V
T
LA
V
A
AF
I
F
N
TTEF
V
P
V
GLL
SD
IA
QS
F
H
M
QTAQV
G
I
M
LT
I
YA
W
V
V
A
LMSL
PFM
L
MT
S
QVE
RR
KL
LI
C
L
F
V
V
F
IA
SH
VLS
F
LS
W
S
F
TV
L
V
ISRI
GVA
F
A
H
AI
F
WS
I
T
A
S
L
A
IR
M
A
P
A
GK
R
A
Q
A
LS
L
I
AT
G
T
A
LA
M
VLG
L
PLG
R
I
V
GQ
Y
FGWRMTF
F
AI
G
IGA
F
I
T
L
L
C
L
IKL
LP
LLPS
E
H
S
G
S
L
-
K
SLPLL
F
RRPA
LM
SI
Y
L
L
TV
V
V
VT
A
H
Y
T
A
YSYI
E
P
F
V
Q
N
I
A
G
F
S
AN
F
A
TA
L
LLL
L
G
G
A
GI
IG
S
V
I
F
GKL
GN
Q
Y
ASALVS
T
AIA
L
LLV
C
LA
L
L
-
L
--
P
A
A
NS
E
IHLG
V
L
---
SIF
WG
I
A
M
MI
I
GL
GM
Q
V
K
VL
AL
A
PD
A
TD
V
AM
A
LFS
G
I
FN
I
G
I
G
A
GA
LV
G
N
Q
V
-
S
-
L
HW
S
M
S
M
I
GYV
GA
V
PA
FAAL
I
W
S
II
I
F
R
R
WPV
TL
fig|656437.3.peg.1766
Escherichia coli TA143 (15-391/396)
V
V
T
LA
V
A
AF
I
F
N
TTEF
V
P
V
GLL
SD
IA
QS
F
H
M
QTAQV
G
I
M
LT
I
YA
W
V
V
A
LMSL
PFM
L
MT
S
QVE
RR
KL
LI
C
L
F
V
V
F
IA
SH
VLS
F
LS
W
S
F
TV
L
V
ISRI
GVA
F
A
H
AI
F
WS
I
T
A
S
L
A
IR
M
A
P
A
GK
R
A
Q
A
LS
L
I
AT
G
T
A
LA
M
VLG
L
PLG
R
I
V
GQ
Y
FGWRMTF
F
AI
G
IGA
F
I
T
L
L
C
L
IKL
LP
LLPS
E
H
S
G
S
L
-
K
SLPLL
F
RRPA
LM
SI
Y
L
L
TV
V
V
VT
A
H
Y
T
A
YSYI
E
P
F
V
Q
N
I
A
G
F
S
AN
F
A
TA
L
LLL
L
G
G
A
GI
IG
S
V
I
F
GKL
GN
Q
Y
ASALVS
T
AIA
L
LLV
C
LA
L
L
-
L
--
P
A
A
NS
E
IHLG
V
L
---
SIF
WG
I
A
M
MI
I
GL
GM
Q
V
K
VL
AL
A
PD
A
TD
V
AM
A
LFS
G
I
FN
I
G
I
G
A
GA
LV
G
N
Q
V
-
S
-
L
HW
S
M
S
M
I
GYV
GA
V
PA
FAAL
I
W
S
II
I
F
R
R
WPV
TL
fig|585056.7.peg.1982
Escherichia coli UMN026 (15-391/396)
V
V
T
LA
V
A
AF
I
F
N
TTEF
V
P
V
GLL
SD
IA
QS
F
H
M
QTAQV
G
I
M
LT
I
YA
W
V
V
A
LMSL
PFM
L
MT
S
QVE
RR
KL
LI
C
L
F
V
V
F
IA
SH
VLS
F
LS
W
S
F
TV
L
V
ISRI
GVA
F
A
H
AI
F
WS
I
T
A
S
L
A
IR
M
A
P
A
GK
R
A
Q
A
LS
L
I
AT
G
T
A
LA
M
VLG
L
PLG
R
I
V
GQ
Y
FGWRMTF
F
AI
G
IGA
F
I
T
L
L
C
L
IKL
LP
LLPS
E
H
S
G
S
L
-
K
SLPLL
F
RRPA
LM
SI
Y
L
L
TV
V
V
VT
A
H
Y
T
A
YSYI
E
P
F
V
Q
N
I
A
G
F
S
AN
F
A
TA
L
LLL
L
G
G
A
GI
IG
S
V
I
F
GKL
GN
Q
Y
ASALVS
T
AIA
L
LLV
C
LA
L
L
-
L
--
P
A
A
NS
E
IHLG
V
L
---
SIF
WG
I
A
M
MI
I
GL
GM
Q
V
K
VL
AL
A
PD
A
TD
V
AM
A
LFS
G
I
FN
I
G
I
G
A
GA
LV
G
N
Q
V
-
S
-
L
HW
S
M
S
M
I
GYV
GA
V
PA
FAAL
I
W
S
II
I
F
R
R
WPV
TL
fig|670897.3.peg.2360
Escherichia coli 2362-75 (15-391/396)
V
V
T
LA
V
A
AF
I
F
N
TTEF
V
P
V
GLL
SD
IA
HS
F
H
M
QTAQV
G
I
M
LT
I
YA
W
V
V
A
LMSL
PFM
L
MT
S
QVE
RR
KL
LI
C
L
F
V
V
F
IA
SH
VLS
F
LS
W
S
F
TV
L
V
ISRI
GVA
F
A
H
AI
F
WS
I
T
A
S
L
A
IR
M
A
P
A
GK
R
A
Q
A
LS
L
I
AT
G
T
A
LA
M
VLG
L
PLG
R
I
V
GQ
Y
FGWRMTF
F
AI
G
IGA
L
I
T
L
L
C
L
IKL
LP
LLPS
E
H
S
G
S
L
-
K
SLPLL
F
RRPA
LM
SI
Y
L
L
TV
V
V
VT
A
H
Y
T
A
YSYI
E
P
F
V
Q
N
I
A
G
F
S
AN
F
A
TA
L
LLL
L
G
G
A
GI
IG
S
V
I
F
GKL
GN
Q
Y
ASALVS
T
AIA
L
LLV
C
LA
L
L
-
L
--
P
A
A
NS
E
IHLG
V
L
---
SIF
WG
I
A
M
MI
I
GL
GM
Q
V
K
VL
AL
A
PD
A
TD
V
AM
A
LFS
G
I
FN
I
G
I
G
A
GA
LV
G
N
Q
V
-
S
-
L
HW
S
M
S
M
I
GYV
GA
V
PA
FAAL
I
W
S
II
I
F
R
R
WPV
TL
fig|655817.3.peg.1837
Escherichia coli ABU 83972 (15-391/396)
V
V
T
LA
V
A
AF
I
F
N
TTEF
V
P
V
GLL
SD
IA
HS
F
H
M
QTAQV
G
I
M
LT
I
YA
W
V
V
A
LMSL
PFM
L
MT
S
QVE
RR
KL
LI
C
L
F
V
V
F
IA
SH
VLS
F
LS
W
S
F
TV
L
V
ISRI
GVA
F
A
H
AI
F
WS
I
T
A
S
L
A
IR
M
A
P
A
GK
R
A
Q
A
LS
L
I
AT
G
T
A
LA
M
VLG
L
PLG
R
I
V
GQ
Y
FGWRMTF
F
AI
G
IGA
L
I
T
L
L
C
L
IKL
LP
LLPS
E
H
S
G
S
L
-
K
SLPLL
F
RRPA
LM
SI
Y
L
L
TV
V
V
VT
A
H
Y
T
A
YSYI
E
P
F
V
Q
N
I
A
G
F
S
AN
F
A
TA
L
LLL
L
G
G
A
GI
IG
S
V
I
F
GKL
GN
Q
Y
ASALVS
T
AIA
L
LLV
C
LA
L
L
-
L
--
P
A
A
NS
E
IHLG
V
L
---
SIF
WG
I
A
M
MI
I
GL
GM
Q
V
K
VL
AL
A
PD
A
TD
V
AM
A
LFS
G
I
FN
I
G
I
G
A
GA
LV
G
N
Q
V
-
S
-
L
HW
S
M
S
M
I
GYV
GA
V
PA
FAAL
I
W
S
II
I
F
R
R
WPV
TL
fig|405955.13.peg.1641
Escherichia coli APEC O1 (15-391/396)
V
V
T
LA
V
A
AF
I
F
N
TTEF
V
P
V
GLL
SD
IA
HS
F
H
M
QTAQV
G
I
M
LT
I
YA
W
V
V
A
LMSL
PFM
L
MT
S
QVE
RR
KL
LI
C
L
F
V
V
F
IA
SH
VLS
F
LS
W
S
F
TV
L
V
ISRI
GVA
F
A
H
AI
F
WS
I
T
A
S
L
A
IR
M
A
P
A
GK
R
A
Q
A
LS
L
I
AT
G
T
A
LA
M
VLG
L
PLG
R
I
V
GQ
Y
FGWRMTF
F
AI
G
IGA
L
I
T
L
L
C
L
IKL
LP
LLPS
E
H
S
G
S
L
-
K
SLPLL
F
RRPA
LM
SI
Y
L
L
TV
V
V
VT
A
H
Y
T
A
YSYI
E
P
F
V
Q
N
I
A
G
F
S
AN
F
A
TA
L
LLL
L
G
G
A
GI
IG
S
V
I
F
GKL
GN
Q
Y
ASALVS
T
AIA
L
LLV
C
LA
L
L
-
L
--
P
A
A
NS
E
IHLG
V
L
---
SIF
WG
I
A
M
MI
I
GL
GM
Q
V
K
VL
AL
A
PD
A
TD
V
AM
A
LFS
G
I
FN
I
G
I
G
A
GA
LV
G
N
Q
V
-
S
-
L
HW
S
M
S
M
I
GYV
GA
V
PA
FAAL
I
W
S
II
I
F
R
R
WPV
TL
fig|405955.9.peg.1332
Escherichia coli APEC O1 (15-391/396)
V
V
T
LA
V
A
AF
I
F
N
TTEF
V
P
V
GLL
SD
IA
HS
F
H
M
QTAQV
G
I
M
LT
I
YA
W
V
V
A
LMSL
PFM
L
MT
S
QVE
RR
KL
LI
C
L
F
V
V
F
IA
SH
VLS
F
LS
W
S
F
TV
L
V
ISRI
GVA
F
A
H
AI
F
WS
I
T
A
S
L
A
IR
M
A
P
A
GK
R
A
Q
A
LS
L
I
AT
G
T
A
LA
M
VLG
L
PLG
R
I
V
GQ
Y
FGWRMTF
F
AI
G
IGA
L
I
T
L
L
C
L
IKL
LP
LLPS
E
H
S
G
S
L
-
K
SLPLL
F
RRPA
LM
SI
Y
L
L
TV
V
V
VT
A
H
Y
T
A
YSYI
E
P
F
V
Q
N
I
A
G
F
S
AN
F
A
TA
L
LLL
L
G
G
A
GI
IG
S
V
I
F
GKL
GN
Q
Y
ASALVS
T
AIA
L
LLV
C
LA
L
L
-
L
--
P
A
A
NS
E
IHLG
V
L
---
SIF
WG
I
A
M
MI
I
GL
GM
Q
V
K
VL
AL
A
PD
A
TD
V
AM
A
LFS
G
I
FN
I
G
I
G
A
GA
LV
G
N
Q
V
-
S
-
L
HW
S
M
S
M
I
GYV
GA
V
PA
FAAL
I
W
S
II
I
F
R
R
WPV
TL
fig|199310.1.peg.1888
Escherichia coli CFT073 (15-391/396)
V
V
T
LA
V
A
AF
I
F
N
TTEF
V
P
V
GLL
SD
IA
HS
F
H
M
QTAQV
G
I
M
LT
I
YA
W
V
V
A
LMSL
PFM
L
MT
S
QVE
RR
KL
LI
C
L
F
V
V
F
IA
SH
VLS
F
LS
W
S
F
TV
L
V
ISRI
GVA
F
A
H
AI
F
WS
I
T
A
S
L
A
IR
M
A
P
A
GK
R
A
Q
A
LS
L
I
AT
G
T
A
LA
M
VLG
L
PLG
R
I
V
GQ
Y
FGWRMTF
F
AI
G
IGA
L
I
T
L
L
C
L
IKL
LP
LLPS
E
H
S
G
S
L
-
K
SLPLL
F
RRPA
LM
SI
Y
L
L
TV
V
V
VT
A
H
Y
T
A
YSYI
E
P
F
V
Q
N
I
A
G
F
S
AN
F
A
TA
L
LLL
L
G
G
A
GI
IG
S
V
I
F
GKL
GN
Q
Y
ASALVS
T
AIA
L
LLV
C
LA
L
L
-
L
--
P
A
A
NS
E
IHLG
V
L
---
SIF
WG
I
A
M
MI
I
GL
GM
Q
V
K
VL
AL
A
PD
A
TD
V
AM
A
LFS
G
I
FN
I
G
I
G
A
GA
LV
G
N
Q
V
-
S
-
L
HW
S
M
S
M
I
GYV
GA
V
PA
FAAL
I
W
S
II
I
F
R
R
WPV
TL
fig|199310.4.peg.1817
Escherichia coli CFT073 (15-391/396)
V
V
T
LA
V
A
AF
I
F
N
TTEF
V
P
V
GLL
SD
IA
HS
F
H
M
QTAQV
G
I
M
LT
I
YA
W
V
V
A
LMSL
PFM
L
MT
S
QVE
RR
KL
LI
C
L
F
V
V
F
IA
SH
VLS
F
LS
W
S
F
TV
L
V
ISRI
GVA
F
A
H
AI
F
WS
I
T
A
S
L
A
IR
M
A
P
A
GK
R
A
Q
A
LS
L
I
AT
G
T
A
LA
M
VLG
L
PLG
R
I
V
GQ
Y
FGWRMTF
F
AI
G
IGA
L
I
T
L
L
C
L
IKL
LP
LLPS
E
H
S
G
S
L
-
K
SLPLL
F
RRPA
LM
SI
Y
L
L
TV
V
V
VT
A
H
Y
T
A
YSYI
E
P
F
V
Q
N
I
A
G
F
S
AN
F
A
TA
L
LLL
L
G
G
A
GI
IG
S
V
I
F
GKL
GN
Q
Y
ASALVS
T
AIA
L
LLV
C
LA
L
L
-
L
--
P
A
A
NS
E
IHLG
V
L
---
SIF
WG
I
A
M
MI
I
GL
GM
Q
V
K
VL
AL
A
PD
A
TD
V
AM
A
LFS
G
I
FN
I
G
I
G
A
GA
LV
G
N
Q
V
-
S
-
L
HW
S
M
S
M
I
GYV
GA
V
PA
FAAL
I
W
S
II
I
F
R
R
WPV
TL
fig|216593.1.peg.332
Escherichia coli E2348/69 (15-391/396)
V
V
T
LA
V
A
AF
I
F
N
TTEF
V
P
V
GLL
SD
IA
HS
F
H
M
QTAQV
G
I
M
LT
I
YA
W
V
V
A
LMSL
PFM
L
MT
S
QVE
RR
KL
LI
C
L
F
V
V
F
IA
SH
VLS
F
LS
W
S
F
TV
L
V
ISRI
GVA
F
A
H
AI
F
WS
I
T
A
S
L
A
IR
M
A
P
A
GK
R
A
Q
A
LS
L
I
AT
G
T
A
LA
M
VLG
L
PLG
R
I
V
GQ
Y
FGWRMTF
F
AI
G
IGA
L
I
T
L
L
C
L
IKL
LP
LLPS
E
H
S
G
S
L
-
K
SLPLL
F
RRPA
LM
SI
Y
L
L
TV
V
V
VT
A
H
Y
T
A
YSYI
E
P
F
V
Q
N
I
A
G
F
S
AN
F
A
TA
L
LLL
L
G
G
A
GI
IG
S
V
I
F
GKL
GN
Q
Y
ASALVS
T
AIA
L
LLV
C
LA
L
L
-
L
--
P
A
A
NS
E
IHLG
V
L
---
SIF
WG
I
A
M
MI
I
GL
GM
Q
V
K
VL
AL
A
PD
A
TD
V
AM
A
LFS
G
I
FN
I
G
I
G
A
GA
LV
G
N
Q
V
-
S
-
L
HW
S
M
S
M
I
GYV
GA
V
PA
FAAL
I
W
S
II
I
F
R
R
WPV
TL
fig|585397.7.peg.1671
Escherichia coli ED1a (15-391/396)
V
V
T
LA
V
A
AF
I
F
N
TTEF
V
P
V
GLL
SD
IA
HS
F
H
M
QTAQV
G
I
M
LT
I
YA
W
V
V
A
LMSL
PFM
L
MT
S
QVE
RR
KL
LI
C
L
F
V
V
F
IA
SH
VLS
F
LS
W
S
F
TV
L
V
ISRI
GVA
F
A
H
AI
F
WS
I
T
A
S
L
A
IR
M
A
P
A
GK
R
A
Q
A
LS
L
I
AT
G
T
A
LA
M
VLG
L
PLG
R
I
V
GQ
Y
FGWRMTF
F
AI
G
IGA
L
I
T
L
L
C
L
IKL
LP
LLPS
E
H
S
G
S
L
-
K
SLPLL
F
RRPA
LM
SI
Y
L
L
TV
V
V
VT
A
H
Y
T
A
YSYI
E
P
F
V
Q
N
I
A
G
F
S
AN
F
A
TA
L
LLL
L
G
G
A
GI
IG
S
V
I
F
GKL
GN
Q
Y
ASALVS
T
AIA
L
LLV
C
LA
L
L
-
L
--
P
A
A
NS
E
IHLG
V
L
---
SIF
WG
I
A
M
MI
I
GL
GM
Q
V
K
VL
AL
A
PD
A
TD
V
AM
A
LFS
G
I
FN
I
G
I
G
A
GA
LV
G
N
Q
V
-
S
-
L
HW
S
M
S
M
I
GYV
GA
V
PA
FAAL
I
W
S
II
I
F
R
R
WPV
TL
fig|585397.9.peg.1665
Escherichia coli ED1a (15-391/396)
V
V
T
LA
V
A
AF
I
F
N
TTEF
V
P
V
GLL
SD
IA
HS
F
H
M
QTAQV
G
I
M
LT
I
YA
W
V
V
A
LMSL
PFM
L
MT
S
QVE
RR
KL
LI
C
L
F
V
V
F
IA
SH
VLS
F
LS
W
S
F
TV
L
V
ISRI
GVA
F
A
H
AI
F
WS
I
T
A
S
L
A
IR
M
A
P
A
GK
R
A
Q
A
LS
L
I
AT
G
T
A
LA
M
VLG
L
PLG
R
I
V
GQ
Y
FGWRMTF
F
AI
G
IGA
L
I
T
L
L
C
L
IKL
LP
LLPS
E
H
S
G
S
L
-
K
SLPLL
F
RRPA
LM
SI
Y
L
L
TV
V
V
VT
A
H
Y
T
A
YSYI
E
P
F
V
Q
N
I
A
G
F
S
AN
F
A
TA
L
LLL
L
G
G
A
GI
IG
S
V
I
F
GKL
GN
Q
Y
ASALVS
T
AIA
L
LLV
C
LA
L
L
-
L
--
P
A
A
NS
E
IHLG
V
L
---
SIF
WG
I
A
M
MI
I
GL
GM
Q
V
K
VL
AL
A
PD
A
TD
V
AM
A
LFS
G
I
FN
I
G
I
G
A
GA
LV
G
N
Q
V
-
S
-
L
HW
S
M
S
M
I
GYV
GA
V
PA
FAAL
I
W
S
II
I
F
R
R
WPV
TL
fig|714962.3.peg.1707
Escherichia coli IHE3034 (15-391/396)
V
V
T
LA
V
A
AF
I
F
N
TTEF
V
P
V
GLL
SD
IA
HS
F
H
M
QTAQV
G
I
M
LT
I
YA
W
V
V
A
LMSL
PFM
L
MT
S
QVE
RR
KL
LI
C
L
F
V
V
F
IA
SH
VLS
F
LS
W
S
F
TV
L
V
ISRI
GVA
F
A
H
AI
F
WS
I
T
A
S
L
A
IR
M
A
P
A
GK
R
A
Q
A
LS
L
I
AT
G
T
A
LA
M
VLG
L
PLG
R
I
V
GQ
Y
FGWRMTF
F
AI
G
IGA
L
I
T
L
L
C
L
IKL
LP
LLPS
E
H
S
G
S
L
-
K
SLPLL
F
RRPA
LM
SI
Y
L
L
TV
V
V
VT
A
H
Y
T
A
YSYI
E
P
F
V
Q
N
I
A
G
F
S
AN
F
A
TA
L
LLL
L
G
G
A
GI
IG
S
V
I
F
GKL
GN
Q
Y
ASALVS
T
AIA
L
LLV
C
LA
L
L
-
L
--
P
A
A
NS
E
IHLG
V
L
---
SIF
WG
I
A
M
MI
I
GL
GM
Q
V
K
VL
AL
A
PD
A
TD
V
AM
A
LFS
G
I
FN
I
G
I
G
A
GA
LV
G
N
Q
V
-
S
-
L
HW
S
M
S
M
I
GYV
GA
V
PA
FAAL
I
W
S
II
I
F
R
R
WPV
TL
fig|656417.3.peg.2052
Escherichia coli M605 (15-391/396)
V
V
T
LA
V
A
AF
I
F
N
TTEF
V
P
V
GLL
SD
IA
HS
F
H
M
QTAQV
G
I
M
LT
I
YA
W
V
V
A
LMSL
PFM
L
MT
S
QVE
RR
KL
LI
C
L
F
V
V
F
IA
SH
VLS
F
LS
W
S
F
TV
L
V
ISRI
GVA
F
A
H
AI
F
WS
I
T
A
S
L
A
IR
M
A
P
A
GK
R
A
Q
A
LS
L
I
AT
G
T
A
LA
M
VLG
L
PLG
R
I
V
GQ
Y
FGWRMTF
F
AI
G
IGA
L
I
T
L
L
C
L
IKL
LP
LLPS
E
H
S
G
S
L
-
K
SLPLL
F
RRPA
LM
SI
Y
L
L
TV
V
V
VT
A
H
Y
T
A
YSYI
E
P
F
V
Q
N
I
A
G
F
S
AN
F
A
TA
L
LLL
L
G
G
A
GI
IG
S
V
I
F
GKL
GN
Q
Y
ASALVS
T
AIA
L
LLV
C
LA
L
L
-
L
--
P
A
A
NS
E
IHLG
V
L
---
SIF
WG
I
A
M
MI
I
GL
GM
Q
V
K
VL
AL
A
PD
A
TD
V
AM
A
LFS
G
I
FN
I
G
I
G
A
GA
LV
G
N
Q
V
-
S
-
L
HW
S
M
S
M
I
GYV
GA
V
PA
FAAL
I
W
S
II
I
F
R
R
WPV
TL
fig|749546.3.peg.3910
Escherichia coli MS 185-1 (15-391/396)
V
V
T
LA
V
A
AF
I
F
N
TTEF
V
P
V
GLL
SD
IA
HS
F
H
M
QTAQV
G
I
M
LT
I
YA
W
V
V
A
LMSL
PFM
L
MT
S
QVE
RR
KL
LI
C
L
F
V
V
F
IA
SH
VLS
F
LS
W
S
F
TV
L
V
ISRI
GVA
F
A
H
AI
F
WS
I
T
A
S
L
A
IR
M
A
P
A
GK
R
A
Q
A
LS
L
I
AT
G
T
A
LA
M
VLG
L
PLG
R
I
V
GQ
Y
FGWRMTF
F
AI
G
IGA
L
I
T
L
L
C
L
IKL
LP
LLPS
E
H
S
G
S
L
-
K
SLPLL
F
RRPA
LM
SI
Y
L
L
TV
V
V
VT
A
H
Y
T
A
YSYI
E
P
F
V
Q
N
I
A
G
F
S
AN
F
A
TA
L
LLL
L
G
G
A
GI
IG
S
V
I
F
GKL
GN
Q
Y
ASALVS
T
AIA
L
LLV
C
LA
L
L
-
L
--
P
A
A
NS
E
IHLG
V
L
---
SIF
WG
I
A
M
MI
I
GL
GM
Q
V
K
VL
AL
A
PD
A
TD
V
AM
A
LFS
G
I
FN
I
G
I
G
A
GA
LV
G
N
Q
V
-
S
-
L
HW
S
M
S
M
I
GYV
GA
V
PA
FAAL
I
W
S
II
I
F
R
R
WPV
TL
fig|749528.3.peg.3887
Escherichia coli MS 45-1 (15-391/396)
V
V
T
LA
V
A
AF
I
F
N
TTEF
V
P
V
GLL
SD
IA
HS
F
H
M
QTAQV
G
I
M
LT
I
YA
W
V
V
A
LMSL
PFM
L
MT
S
QVE
RR
KL
LI
C
L
F
V
V
F
IA
SH
VLS
F
LS
W
S
F
TV
L
V
ISRI
GVA
F
A
H
AI
F
WS
I
T
A
S
L
A
IR
M
A
P
A
GK
R
A
Q
A
LS
L
I
AT
G
T
A
LA
M
VLG
L
PLG
R
I
V
GQ
Y
FGWRMTF
F
AI
G
IGA
L
I
T
L
L
C
L
IKL
LP
LLPS
E
H
S
G
S
L
-
K
SLPLL
F
RRPA
LM
SI
Y
L
L
TV
V
V
VT
A
H
Y
T
A
YSYI
E
P
F
V
Q
N
I
A
G
F
S
AN
F
A
TA
L
LLL
L
G
G
A
GI
IG
S
V
I
F
GKL
GN
Q
Y
ASALVS
T
AIA
L
LLV
C
LA
L
L
-
L
--
P
A
A
NS
E
IHLG
V
L
---
SIF
WG
I
A
M
MI
I
GL
GM
Q
V
K
VL
AL
A
PD
A
TD
V
AM
A
LFS
G
I
FN
I
G
I
G
A
GA
LV
G
N
Q
V
-
S
-
L
HW
S
M
S
M
I
GYV
GA
V
PA
FAAL
I
W
S
II
I
F
R
R
WPV
TL
fig|574521.7.peg.1684
Escherichia coli O127:H6 str. E2348/69 (15-391/396)
V
V
T
LA
V
A
AF
I
F
N
TTEF
V
P
V
GLL
SD
IA
HS
F
H
M
QTAQV
G
I
M
LT
I
YA
W
V
V
A
LMSL
PFM
L
MT
S
QVE
RR
KL
LI
C
L
F
V
V
F
IA
SH
VLS
F
LS
W
S
F
TV
L
V
ISRI
GVA
F
A
H
AI
F
WS
I
T
A
S
L
A
IR
M
A
P
A
GK
R
A
Q
A
LS
L
I
AT
G
T
A
LA
M
VLG
L
PLG
R
I
V
GQ
Y
FGWRMTF
F
AI
G
IGA
L
I
T
L
L
C
L
IKL
LP
LLPS
E
H
S
G
S
L
-
K
SLPLL
F
RRPA
LM
SI
Y
L
L
TV
V
V
VT
A
H
Y
T
A
YSYI
E
P
F
V
Q
N
I
A
G
F
S
AN
F
A
TA
L
LLL
L
G
G
A
GI
IG
S
V
I
F
GKL
GN
Q
Y
ASALVS
T
AIA
L
LLV
C
LA
L
L
-
L
--
P
A
A
NS
E
IHLG
V
L
---
SIF
WG
I
A
M
MI
I
GL
GM
Q
V
K
VL
AL
A
PD
A
TD
V
AM
A
LFS
G
I
FN
I
G
I
G
A
GA
LV
G
N
Q
V
-
S
-
L
HW
S
M
S
M
I
GYV
GA
V
PA
FAAL
I
W
S
II
I
F
R
R
WPV
TL
fig|585035.6.peg.1596
Escherichia coli S88 (15-391/396)
V
V
T
LA
V
A
AF
I
F
N
TTEF
V
P
V
GLL
SD
IA
HS
F
H
M
QTAQV
G
I
M
LT
I
YA
W
V
V
A
LMSL
PFM
L
MT
S
QVE
RR
KL
LI
C
L
F
V
V
F
IA
SH
VLS
F
LS
W
S
F
TV
L
V
ISRI
GVA
F
A
H
AI
F
WS
I
T
A
S
L
A
IR
M
A
P
A
GK
R
A
Q
A
LS
L
I
AT
G
T
A
LA
M
VLG
L
PLG
R
I
V
GQ
Y
FGWRMTF
F
AI
G
IGA
L
I
T
L
L
C
L
IKL
LP
LLPS
E
H
S
G
S
L
-
K
SLPLL
F
RRPA
LM
SI
Y
L
L
TV
V
V
VT
A
H
Y
T
A
YSYI
E
P
F
V
Q
N
I
A
G
F
S
AN
F
A
TA
L
LLL
L
G
G
A
GI
IG
S
V
I
F
GKL
GN
Q
Y
ASALVS
T
AIA
L
LLV
C
LA
L
L
-
L
--
P
A
A
NS
E
IHLG
V
L
---
SIF
WG
I
A
M
MI
I
GL
GM
Q
V
K
VL
AL
A
PD
A
TD
V
AM
A
LFS
G
I
FN
I
G
I
G
A
GA
LV
G
N
Q
V
-
S
-
L
HW
S
M
S
M
I
GYV
GA
V
PA
FAAL
I
W
S
II
I
F
R
R
WPV
TL
fig|869729.3.peg.1991
Escherichia coli UM146 (15-391/396)
V
V
T
LA
V
A
AF
I
F
N
TTEF
V
P
V
GLL
SD
IA
HS
F
H
M
QTAQV
G
I
M
LT
I
YA
W
V
V
A
LMSL
PFM
L
MT
S
QVE
RR
KL
LI
C
L
F
V
V
F
IA
SH
VLS
F
LS
W
S
F
TV
L
V
ISRI
GVA
F
A
H
AI
F
WS
I
T
A
S
L
A
IR
M
A
P
A
GK
R
A
Q
A
LS
L
I
AT
G
T
A
LA
M
VLG
L
PLG
R
I
V
GQ
Y
FGWRMTF
F
AI
G
IGA
L
I
T
L
L
C
L
IKL
LP
LLPS
E
H
S
G
S
L
-
K
SLPLL
F
RRPA
LM
SI
Y
L
L
TV
V
V
VT
A
H
Y
T
A
YSYI
E
P
F
V
Q
N
I
A
G
F
S
AN
F
A
TA
L
LLL
L
G
G
A
GI
IG
S
V
I
F
GKL
GN
Q
Y
ASALVS
T
AIA
L
LLV
C
LA
L
L
-
L
--
P
A
A
NS
E
IHLG
V
L
---
SIF
WG
I
A
M
MI
I
GL
GM
Q
V
K
VL
AL
A
PD
A
TD
V
AM
A
LFS
G
I
FN
I
G
I
G
A
GA
LV
G
N
Q
V
-
S
-
L
HW
S
M
S
M
I
GYV
GA
V
PA
FAAL
I
W
S
II
I
F
R
R
WPV
TL
fig|364106.7.peg.1788
Escherichia coli UTI89 (15-391/396)
V
V
T
LA
V
A
AF
I
F
N
TTEF
V
P
V
GLL
SD
IA
HS
F
H
M
QTAQV
G
I
M
LT
I
YA
W
V
V
A
LMSL
PFM
L
MT
S
QVE
RR
KL
LI
C
L
F
V
V
F
IA
SH
VLS
F
LS
W
S
F
TV
L
V
ISRI
GVA
F
A
H
AI
F
WS
I
T
A
S
L
A
IR
M
A
P
A
GK
R
A
Q
A
LS
L
I
AT
G
T
A
LA
M
VLG
L
PLG
R
I
V
GQ
Y
FGWRMTF
F
AI
G
IGA
L
I
T
L
L
C
L
IKL
LP
LLPS
E
H
S
G
S
L
-
K
SLPLL
F
RRPA
LM
SI
Y
L
L
TV
V
V
VT
A
H
Y
T
A
YSYI
E
P
F
V
Q
N
I
A
G
F
S
AN
F
A
TA
L
LLL
L
G
G
A
GI
IG
S
V
I
F
GKL
GN
Q
Y
ASALVS
T
AIA
L
LLV
C
LA
L
L
-
L
--
P
A
A
NS
E
IHLG
V
L
---
SIF
WG
I
A
M
MI
I
GL
GM
Q
V
K
VL
AL
A
PD
A
TD
V
AM
A
LFS
G
I
FN
I
G
I
G
A
GA
LV
G
N
Q
V
-
S
-
L
HW
S
M
S
M
I
GYV
GA
V
PA
FAAL
I
W
S
II
I
F
R
R
WPV
TL
fig|364106.8.peg.1791
Escherichia coli UTI89 (15-391/396)
V
V
T
LA
V
A
AF
I
F
N
TTEF
V
P
V
GLL
SD
IA
HS
F
H
M
QTAQV
G
I
M
LT
I
YA
W
V
V
A
LMSL
PFM
L
MT
S
QVE
RR
KL
LI
C
L
F
V
V
F
IA
SH
VLS
F
LS
W
S
F
TV
L
V
ISRI
GVA
F
A
H
AI
F
WS
I
T
A
S
L
A
IR
M
A
P
A
GK
R
A
Q
A
LS
L
I
AT
G
T
A
LA
M
VLG
L
PLG
R
I
V
GQ
Y
FGWRMTF
F
AI
G
IGA
L
I
T
L
L
C
L
IKL
LP
LLPS
E
H
S
G
S
L
-
K
SLPLL
F
RRPA
LM
SI
Y
L
L
TV
V
V
VT
A
H
Y
T
A
YSYI
E
P
F
V
Q
N
I
A
G
F
S
AN
F
A
TA
L
LLL
L
G
G
A
GI
IG
S
V
I
F
GKL
GN
Q
Y
ASALVS
T
AIA
L
LLV
C
LA
L
L
-
L
--
P
A
A
NS
E
IHLG
V
L
---
SIF
WG
I
A
M
MI
I
GL
GM
Q
V
K
VL
AL
A
PD
A
TD
V
AM
A
LFS
G
I
FN
I
G
I
G
A
GA
LV
G
N
Q
V
-
S
-
L
HW
S
M
S
M
I
GYV
GA
V
PA
FAAL
I
W
S
II
I
F
R
R
WPV
TL
fig|749538.3.peg.4112
Escherichia coli MS 116-1 (6-382/387)
V
V
T
LA
V
A
AF
I
F
N
TTEF
V
P
V
GLL
SD
IA
QS
F
H
M
QTAQV
G
I
M
LT
I
YA
W
V
V
A
LMSL
PFM
L
MT
S
QVE
RR
KL
LI
C
L
F
V
V
F
IA
SH
VLS
F
LS
W
S
F
TV
L
V
ISRI
GVA
F
A
H
AI
F
WS
I
T
A
S
L
A
IR
M
A
P
A
GK
R
A
Q
A
LS
L
I
AT
G
T
A
LA
M
VLG
L
PLG
R
I
V
GQ
Y
FGWRMTF
F
AI
G
IGA
L
I
T
L
L
C
L
IKL
LP
LLPS
E
H
S
G
S
L
-
K
SLPLL
F
RRPA
LM
SI
Y
L
L
TV
V
V
VT
A
H
Y
T
A
YSYI
E
P
F
V
Q
N
I
A
G
F
S
AN
F
A
TA
L
LLL
L
G
G
A
GI
IG
S
V
I
F
GKL
GN
Q
Y
ASALVS
T
AIA
L
LLV
C
LA
L
L
-
L
--
P
A
A
NS
E
IHLG
V
L
---
SIF
WG
I
A
M
MI
I
GL
GM
Q
V
K
VL
AL
A
PD
A
TD
V
AM
A
LFS
G
I
FN
I
G
I
G
A
GA
LV
G
N
Q
V
-
S
-
L
HW
S
M
S
M
I
GYV
GA
V
PA
FAAL
I
W
S
II
I
F
R
R
WPV
TL
fig|439855.10.peg.1803
Escherichia coli SMS-3-5 (15-391/396)
V
V
T
LA
V
A
AF
I
F
N
TTEF
V
P
V
GLL
SD
IA
QS
F
H
M
QTAQV
G
I
M
LT
I
YA
W
V
V
A
LMSL
PFM
L
MT
S
QVE
RR
KL
LI
C
L
F
V
V
F
IA
SH
VLS
F
LS
W
S
F
TV
L
V
ISRI
GVA
F
A
H
AI
F
WS
I
T
A
S
L
A
IR
M
A
P
A
GK
R
A
Q
A
LS
L
I
AT
G
T
A
LA
M
VLG
L
PLG
R
I
V
GQ
Y
FGWRMTF
F
AI
G
IGA
L
I
T
L
L
C
L
IKL
LP
LLPS
E
H
S
G
S
L
-
K
SLPLL
F
RRPA
LM
SI
Y
L
L
TV
V
V
VT
A
H
Y
T
A
YSYI
E
P
F
V
Q
N
I
A
G
F
S
AN
F
A
TA
L
LLL
L
G
G
A
GI
IG
S
V
I
F
GKL
GN
Q
Y
ASTLVS
T
AIA
L
LLV
C
LA
L
L
-
L
--
P
A
A
NS
E
IHLG
V
L
---
SIF
WG
I
A
M
MI
I
GL
GM
Q
V
K
VL
AL
A
PD
A
TD
V
AM
A
LFS
G
I
FN
I
G
I
G
A
GA
LV
G
N
Q
V
-
S
-
L
HW
S
M
S
M
I
GYV
GA
V
PA
FAAL
I
W
S
II
I
F
R
R
WPV
TL
fig|431946.3.peg.1482
Escherichia coli SE15 (15-391/396)
V
V
T
LA
V
A
AF
I
F
N
TTEF
V
P
V
GLL
SD
IA
HS
F
H
M
QTAQV
G
I
M
LT
I
YA
W
V
V
A
LMSL
PFM
L
MT
S
QVE
RR
KL
LI
C
L
F
V
V
F
IA
SH
VLS
F
LS
W
S
F
TV
L
V
ISRI
GVA
F
A
H
AI
F
WS
I
T
A
S
L
A
IR
M
A
P
A
GK
R
A
Q
A
LS
L
I
AT
G
T
A
LA
M
VLG
L
PLG
R
I
V
GQ
Y
FGWRMTF
F
AI
G
IGA
LL
T
L
L
C
L
IKL
LP
LLPS
E
H
S
G
S
L
-
K
SLPLL
F
RRPA
LM
SI
Y
L
L
TV
V
V
VT
A
H
Y
T
A
YSYI
E
P
F
V
Q
N
I
A
G
F
S
AN
F
A
TA
L
LLL
L
G
G
A
GI
IG
S
V
I
F
GKL
GN
Q
Y
ASALVS
T
AIA
L
LLV
C
LA
L
L
-
L
--
P
A
A
NS
E
IHLG
V
L
---
SIF
WG
I
A
M
MI
I
GL
GM
Q
V
K
VL
AL
A
PD
A
TD
V
AM
A
LFS
G
I
FN
I
G
I
G
A
GA
LV
G
N
Q
V
-
S
-
L
HW
S
M
S
M
I
GYV
GA
V
PA
FAAL
I
W
S
II
I
F
R
R
WPV
TL
fig|340197.3.peg.4278
Escherichia coli F11 (15-391/396)
V
V
T
LA
V
A
AF
I
F
N
TTEF
V
P
V
GLL
SD
IA
HS
F
H
M
QTAQV
G
I
M
LT
I
YA
W
V
V
A
LMSL
PFM
L
MT
S
QVE
RR
KL
LI
C
L
F
V
V
F
IA
SH
VLS
F
LS
W
S
F
TV
L
V
ISRI
GVA
F
A
H
AI
F
WS
I
T
A
S
L
A
IR
M
A
P
A
GK
R
A
Q
A
LS
L
I
AT
G
T
A
LA
M
VLG
L
PLG
R
I
V
GQ
Y
FGWRMTF
F
AI
G
IGA
L
I
T
L
L
C
L
IKL
LP
LLPS
E
H
S
G
S
L
-
K
SLPLL
F
RRPA
LM
SI
Y
L
L
TV
V
V
VT
A
H
Y
T
A
YSYI
E
P
F
V
Q
N
I
A
G
F
S
AN
F
A
TA
L
LLL
L
G
G
A
GI
IG
S
V
I
F
GKL
GN
Q
Y
ASALVS
T
AIA
L
LLV
C
LA
L
L
-
L
--
P
A
A
NS
E
IHLG
M
L
---
SIF
WG
I
A
M
MI
I
GL
GM
Q
V
K
VL
AL
A
PD
A
TD
V
AM
A
LFS
G
I
FN
I
G
I
G
A
GA
LV
G
N
Q
V
-
S
-
L
HW
S
M
S
M
I
GYV
GA
V
PA
FAAL
I
W
S
II
I
F
R
R
WPV
TL
fig|749550.3.peg.1162
Escherichia coli MS 200-1 (15-391/396)
V
V
T
LA
V
A
AF
I
F
N
TTEF
V
P
V
GLL
SD
IA
HS
F
H
M
QTAQV
G
I
M
LT
I
YA
W
V
V
A
LMSL
PFM
L
MT
S
QVE
RR
KL
LI
C
L
F
V
V
F
IA
SH
VLS
F
LS
W
S
F
TV
L
V
ISRI
GVA
F
A
H
AI
F
WS
I
T
A
S
L
A
IR
M
A
P
A
GK
R
A
Q
A
LS
L
I
AT
G
T
A
LA
M
VLG
L
PLG
R
I
V
GQ
Y
FGWRMTF
F
AI
G
IGA
L
I
T
L
L
C
L
IKL
LP
LLPS
E
H
S
G
S
L
-
K
SLPLL
F
RRPA
LM
SI
Y
L
L
TV
V
V
VT
A
H
Y
T
A
YSYI
E
P
F
V
Q
N
I
A
G
F
S
AN
F
A
TA
L
LLL
L
G
G
A
GI
IG
S
V
I
F
GKL
GN
Q
Y
ASALVS
T
AIA
L
LLV
C
LA
L
L
-
L
--
P
A
A
NS
E
IHLG
M
L
---
SIF
WG
I
A
M
MI
I
GL
GM
Q
V
K
VL
AL
A
PD
A
TD
V
AM
A
LFS
G
I
FN
I
G
I
G
A
GA
LV
G
N
Q
V
-
S
-
L
HW
S
M
S
M
I
GYV
GA
V
PA
FAAL
I
W
S
II
I
F
R
R
WPV
TL
fig|562.371.peg.1670
Escherichia coli 1044A (15-391/396)
V
V
T
LA
V
A
AF
I
F
N
TTEF
V
P
V
GLL
SD
IA
QS
F
H
M
QTAQV
G
I
M
LT
I
YA
W
V
V
A
LMSL
PFM
L
MT
S
QVE
RR
KL
LI
C
L
F
V
V
F
IA
SH
VLS
F
LS
W
S
F
TV
L
V
ISRI
GVA
F
A
H
AI
F
WS
I
T
A
S
L
A
IR
M
A
P
A
GK
R
A
Q
A
LS
L
I
AT
G
T
A
LA
M
VLG
L
PLG
R
I
V
GQ
Y
FGWRMTF
F
AI
G
IGA
L
I
T
L
L
C
L
IKL
LP
LLPS
E
H
S
G
S
L
-
K
SLPLL
F
RRPA
LM
SI
Y
L
L
TV
V
V
VT
A
H
Y
T
A
YSYI
E
P
F
V
Q
N
I
A
G
F
S
AN
F
A
TA
L
LLL
L
G
G
A
GI
IG
S
V
I
F
GKL
GN
Q
Y
ASALVS
T
AIA
L
LLV
C
LA
L
L
-
L
--
P
A
A
NS
E
IHLG
V
L
---
SIF
WG
I
A
M
MI
I
GL
GM
Q
V
K
VL
AL
A
PD
A
TD
V
AM
A
LFS
G
I
FN
I
G
I
G
A
GA
LV
G
N
Q
V
-
S
-
L
HW
S
M
S
M
I
GYV
G
T
V
PA
FAAL
I
W
S
II
I
F
R
R
WPV
TL
fig|562.372.peg.1156
Escherichia coli 1212A (15-391/396)
V
V
T
LA
V
A
AF
I
F
N
TTEF
V
P
V
GLL
SD
IA
QS
F
H
M
QTAQV
G
I
M
LT
I
YA
W
V
V
A
LMSL
PFM
L
MT
S
QVE
RR
KL
LI
C
L
F
V
V
F
IA
SH
VLS
F
LS
W
S
F
TV
L
V
ISRI
GVA
F
A
H
AI
F
WS
I
T
A
S
L
A
IR
M
A
P
A
GK
R
A
Q
A
LS
L
I
AT
G
T
A
LA
M
VLG
L
PLG
R
I
V
GQ
Y
FGWRMTF
F
AI
G
IGA
L
I
T
L
L
C
L
IKL
LP
LLPS
E
H
S
G
S
L
-
K
SLPLL
F
RRPA
LM
SI
Y
L
L
TV
V
V
VT
A
H
Y
T
A
YSYI
E
P
F
V
Q
N
I
A
G
F
S
AN
F
A
TA
L
LLL
L
G
G
A
GI
IG
S
V
I
F
GKL
GN
Q
Y
ASALVS
T
AIA
L
LLV
C
LA
L
L
-
L
--
P
A
A
NS
E
IHLG
V
L
---
SIF
WG
I
A
M
MI
I
GL
GM
Q
V
K
VL
AL
A
PD
A
TD
V
AM
A
LFS
G
I
FN
I
G
I
G
A
GA
LV
G
N
Q
V
-
S
-
L
HW
S
M
S
M
I
GYV
G
T
V
PA
FAAL
I
W
S
II
I
F
R
R
WPV
TL
fig|562.374.peg.2428
Escherichia coli 536A (15-391/396)
V
V
T
LA
V
A
AF
I
F
N
TTEF
V
P
V
GLL
SD
IA
QS
F
H
M
QTAQV
G
I
M
LT
I
YA
W
V
V
A
LMSL
PFM
L
MT
S
QVE
RR
KL
LI
C
L
F
V
V
F
IA
SH
VLS
F
LS
W
S
F
TV
L
V
ISRI
GVA
F
A
H
AI
F
WS
I
T
A
S
L
A
IR
M
A
P
A
GK
R
A
Q
A
LS
L
I
AT
G
T
A
LA
M
VLG
L
PLG
R
I
V
GQ
Y
FGWRMTF
F
AI
G
IGA
L
I
T
L
L
C
L
IKL
LP
LLPS
E
H
S
G
S
L
-
K
SLPLL
F
RRPA
LM
SI
Y
L
L
TV
V
V
VT
A
H
Y
T
A
YSYI
E
P
F
V
Q
N
I
A
G
F
S
AN
F
A
TA
L
LLL
L
G
G
A
GI
IG
S
V
I
F
GKL
GN
Q
Y
ASALVS
T
AIA
L
LLV
C
LA
L
L
-
L
--
P
A
A
NS
E
IHLG
V
L
---
SIF
WG
I
A
M
MI
I
GL
GM
Q
V
K
VL
AL
A
PD
A
TD
V
AM
A
LFS
G
I
FN
I
G
I
G
A
GA
LV
G
N
Q
V
-
S
-
L
HW
S
M
S
M
I
GYV
G
T
V
PA
FAAL
I
W
S
II
I
F
R
R
WPV
TL
fig|550672.3.peg.2397
Escherichia coli B088 (15-391/396)
V
V
T
LA
V
A
AF
I
F
N
TTEF
V
P
V
GLL
SD
IA
QS
F
H
M
QTAQV
G
I
M
LT
I
Y
T
W
V
V
A
LMSL
PFM
L
MT
S
QVE
RR
KL
LI
C
L
F
V
V
F
IA
SH
VLS
F
LS
W
S
F
TV
L
V
ISRI
GVA
F
A
H
AI
F
WS
I
T
A
S
L
A
IR
M
A
P
A
GK
R
A
Q
A
LS
L
I
AT
G
T
A
LA
M
VLG
L
PLG
R
I
V
GQ
Y
FGWRMTF
F
AI
G
IGA
L
I
T
L
L
C
L
IKL
LP
LLPS
E
H
S
G
S
L
-
K
SLPLL
F
RRPA
LM
SI
Y
L
L
TV
V
V
VT
A
H
Y
T
A
YSYI
E
P
F
V
Q
N
I
A
G
F
S
AN
F
A
TA
L
LLL
L
G
G
A
GI
IG
S
V
I
F
GKL
GN
Q
Y
ASALVS
T
AIA
L
LLV
C
LA
L
L
-
L
--
P
A
A
NS
E
IHLG
V
L
---
SIF
WG
I
A
M
MI
I
GL
GM
Q
V
K
VL
AL
A
PD
A
TD
V
AM
A
LFS
G
I
FN
I
G
I
G
A
GA
LV
G
N
Q
V
-
S
-
L
HW
S
M
S
M
I
GYV
GA
V
PA
FAAL
I
W
S
II
I
F
R
R
WPV
TL
fig|83334.1.peg.2162
Escherichia coli O157:H7 (15-391/396)
V
V
T
LA
V
A
AF
I
F
N
TTEF
V
P
V
GLL
SD
IA
QS
F
H
M
QTAQV
G
I
M
LT
I
YA
W
V
V
A
LMSL
PFM
L
MT
S
QVE
RR
KL
LI
C
L
F
V
V
F
IA
SH
VLS
F
LS
W
S
F
TV
L
V
ISRI
GVA
F
A
H
AI
F
WS
I
T
A
S
L
A
IR
M
A
P
A
GK
R
A
Q
A
LS
L
I
AT
G
T
A
LA
M
VLG
L
PLG
R
I
V
GQ
Y
FGWRMTF
F
AI
G
IGA
L
I
T
L
L
C
L
IKL
LP
LLPS
E
H
S
G
S
L
-
K
SLPLL
F
RRPA
LM
SI
Y
L
L
TV
V
V
VT
A
H
Y
T
A
YSYI
E
P
F
V
Q
N
I
A
G
F
S
AN
F
A
TA
L
LLL
L
G
G
A
GI
IG
S
V
I
F
GKL
GN
Q
Y
ASALVS
T
AIA
L
LLV
C
LA
L
L
-
L
--
P
A
A
NS
E
IHLG
V
L
---
SIF
WG
I
A
M
MI
I
GL
GM
Q
V
K
VL
AL
A
PD
A
TD
V
AM
A
LFS
G
I
FN
I
G
I
G
A
GA
LV
G
N
Q
V
-
S
-
L
HW
S
M
S
M
I
GYV
G
T
V
PA
FAAL
I
W
S
II
I
F
R
R
WPV
TL
fig|155864.1.peg.1932
Escherichia coli O157:H7 EDL933 (15-391/396)
V
V
T
LA
V
A
AF
I
F
N
TTEF
V
P
V
GLL
SD
IA
QS
F
H
M
QTAQV
G
I
M
LT
I
YA
W
V
V
A
LMSL
PFM
L
MT
S
QVE
RR
KL
LI
C
L
F
V
V
F
IA
SH
VLS
F
LS
W
S
F
TV
L
V
ISRI
GVA
F
A
H
AI
F
WS
I
T
A
S
L
A
IR
M
A
P
A
GK
R
A
Q
A
LS
L
I
AT
G
T
A
LA
M
VLG
L
PLG
R
I
V
GQ
Y
FGWRMTF
F
AI
G
IGA
L
I
T
L
L
C
L
IKL
LP
LLPS
E
H
S
G
S
L
-
K
SLPLL
F
RRPA
LM
SI
Y
L
L
TV
V
V
VT
A
H
Y
T
A
YSYI
E
P
F
V
Q
N
I
A
G
F
S
AN
F
A
TA
L
LLL
L
G
G
A
GI
IG
S
V
I
F
GKL
GN
Q
Y
ASALVS
T
AIA
L
LLV
C
LA
L
L
-
L
--
P
A
A
NS
E
IHLG
V
L
---
SIF
WG
I
A
M
MI
I
GL
GM
Q
V
K
VL
AL
A
PD
A
TD
V
AM
A
LFS
G
I
FN
I
G
I
G
A
GA
LV
G
N
Q
V
-
S
-
L
HW
S
M
S
M
I
GYV
G
T
V
PA
FAAL
I
W
S
II
I
F
R
R
WPV
TL
fig|155864.8.peg.1754
Escherichia coli O157:H7 EDL933 (15-391/396)
V
V
T
LA
V
A
AF
I
F
N
TTEF
V
P
V
GLL
SD
IA
QS
F
H
M
QTAQV
G
I
M
LT
I
YA
W
V
V
A
LMSL
PFM
L
MT
S
QVE
RR
KL
LI
C
L
F
V
V
F
IA
SH
VLS
F
LS
W
S
F
TV
L
V
ISRI
GVA
F
A
H
AI
F
WS
I
T
A
S
L
A
IR
M
A
P
A
GK
R
A
Q
A
LS
L
I
AT
G
T
A
LA
M
VLG
L
PLG
R
I
V
GQ
Y
FGWRMTF
F
AI
G
IGA
L
I
T
L
L
C
L
IKL
LP
LLPS
E
H
S
G
S
L
-
K
SLPLL
F
RRPA
LM
SI
Y
L
L
TV
V
V
VT
A
H
Y
T
A
YSYI
E
P
F
V
Q
N
I
A
G
F
S
AN
F
A
TA
L
LLL
L
G
G
A
GI
IG
S
V
I
F
GKL
GN
Q
Y
ASALVS
T
AIA
L
LLV
C
LA
L
L
-
L
--
P
A
A
NS
E
IHLG
V
L
---
SIF
WG
I
A
M
MI
I
GL
GM
Q
V
K
VL
AL
A
PD
A
TD
V
AM
A
LFS
G
I
FN
I
G
I
G
A
GA
LV
G
N
Q
V
-
S
-
L
HW
S
M
S
M
I
GYV
G
T
V
PA
FAAL
I
W
S
II
I
F
R
R
WPV
TL
fig|478006.5.peg.1877
Escherichia coli O157:H7 str. EC4501 (15-391/396)
V
V
T
LA
V
A
AF
I
F
N
TTEF
V
P
V
GLL
SD
IA
QS
F
H
M
QTAQV
G
I
M
LT
I
YA
W
V
V
A
LMSL
PFM
L
MT
S
QVE
RR
KL
LI
C
L
F
V
V
F
IA
SH
VLS
F
LS
W
S
F
TV
L
V
ISRI
GVA
F
A
H
AI
F
WS
I
T
A
S
L
A
IR
M
A
P
A
GK
R
A
Q
A
LS
L
I
AT
G
T
A
LA
M
VLG
L
PLG
R
I
V
GQ
Y
FGWRMTF
F
AI
G
IGA
L
I
T
L
L
C
L
IKL
LP
LLPS
E
H
S
G
S
L
-
K
SLPLL
F
RRPA
LM
SI
Y
L
L
TV
V
V
VT
A
H
Y
T
A
YSYI
E
P
F
V
Q
N
I
A
G
F
S
AN
F
A
TA
L
LLL
L
G
G
A
GI
IG
S
V
I
F
GKL
GN
Q
Y
ASALVS
T
AIA
L
LLV
C
LA
L
L
-
L
--
P
A
A
NS
E
IHLG
V
L
---
SIF
WG
I
A
M
MI
I
GL
GM
Q
V
K
VL
AL
A
PD
A
TD
V
AM
A
LFS
G
I
FN
I
G
I
G
A
GA
LV
G
N
Q
V
-
S
-
L
HW
S
M
S
M
I
GYV
G
T
V
PA
FAAL
I
W
S
II
I
F
R
R
WPV
TL
fig|478008.5.peg.3601
Escherichia coli O157:H7 str. EC869 (15-391/396)
V
V
T
LA
V
A
AF
I
F
N
TTEF
V
P
V
GLL
SD
IA
QS
F
H
M
QTAQV
G
I
M
LT
I
YA
W
V
V
A
LMSL
PFM
L
MT
S
QVE
RR
KL
LI
C
L
F
V
V
F
IA
SH
VLS
F
LS
W
S
F
TV
L
V
ISRI
GVA
F
A
H
AI
F
WS
I
T
A
S
L
A
IR
M
A
P
A
GK
R
A
Q
A
LS
L
I
AT
G
T
A
LA
M
VLG
L
PLG
R
I
V
GQ
Y
FGWRMTF
F
AI
G
IGA
L
I
T
L
L
C
L
IKL
LP
LLPS
E
H
S
G
S
L
-
K
SLPLL
F
RRPA
LM
SI
Y
L
L
TV
V
V
VT
A
H
Y
T
A
YSYI
E
P
F
V
Q
N
I
A
G
F
S
AN
F
A
TA
L
LLL
L
G
G
A
GI
IG
S
V
I
F
GKL
GN
Q
Y
ASALVS
T
AIA
L
LLV
C
LA
L
L
-
L
--
P
A
A
NS
E
IHLG
V
L
---
SIF
WG
I
A
M
MI
I
GL
GM
Q
V
K
VL
AL
A
PD
A
TD
V
AM
A
LFS
G
I
FN
I
G
I
G
A
GA
LV
G
N
Q
V
-
S
-
L
HW
S
M
S
M
I
GYV
G
T
V
PA
FAAL
I
W
S
II
I
F
R
R
WPV
TL
fig|637388.3.peg.1588
Escherichia coli O157:H7 str. FRIK2000 (15-391/396)
V
V
T
LA
V
A
AF
I
F
N
TTEF
V
P
V
GLL
SD
IA
QS
F
H
M
QTAQV
G
I
M
LT
I
YA
W
V
V
A
LMSL
PFM
L
MT
S
QVE
RR
KL
LI
C
L
F
V
V
F
IA
SH
VLS
F
LS
W
S
F
TV
L
V
ISRI
GVA
F
A
H
AI
F
WS
I
T
A
S
L
A
IR
M
A
P
A
GK
R
A
Q
A
LS
L
I
AT
G
T
A
LA
M
VLG
L
PLG
R
I
V
GQ
Y
FGWRMTF
F
AI
G
IGA
L
I
T
L
L
C
L
IKL
LP
LLPS
E
H
S
G
S
L
-
K
SLPLL
F
RRPA
LM
SI
Y
L
L
TV
V
V
VT
A
H
Y
T
A
YSYI
E
P
F
V
Q
N
I
A
G
F
S
AN
F
A
TA
L
LLL
L
G
G
A
GI
IG
S
V
I
F
GKL
GN
Q
Y
ASALVS
T
AIA
L
LLV
C
LA
L
L
-
L
--
P
A
A
NS
E
IHLG
V
L
---
SIF
WG
I
A
M
MI
I
GL
GM
Q
V
K
VL
AL
A
PD
A
TD
V
AM
A
LFS
G
I
FN
I
G
I
G
A
GA
LV
G
N
Q
V
-
S
-
L
HW
S
M
S
M
I
GYV
G
T
V
PA
FAAL
I
W
S
II
I
F
R
R
WPV
TL
fig|570506.3.peg.2959
Escherichia coli O157:H7 str. FRIK966 (15-391/396)
V
V
T
LA
V
A
AF
I
F
N
TTEF
V
P
V
GLL
SD
IA
QS
F
H
M
QTAQV
G
I
M
LT
I
YA
W
V
V
A
LMSL
PFM
L
MT
S
QVE
RR
KL
LI
C
L
F
V
V
F
IA
SH
VLS
F
LS
W
S
F
TV
L
V
ISRI
GVA
F
A
H
AI
F
WS
I
T
A
S
L
A
IR
M
A
P
A
GK
R
A
Q
A
LS
L
I
AT
G
T
A
LA
M
VLG
L
PLG
R
I
V
GQ
Y
FGWRMTF
F
AI
G
IGA
L
I
T
L
L
C
L
IKL
LP
LLPS
E
H
S
G
S
L
-
K
SLPLL
F
RRPA
LM
SI
Y
L
L
TV
V
V
VT
A
H
Y
T
A
YSYI
E
P
F
V
Q
N
I
A
G
F
S
AN
F
A
TA
L
LLL
L
G
G
A
GI
IG
S
V
I
F
GKL
GN
Q
Y
ASALVS
T
AIA
L
LLV
C
LA
L
L
-
L
--
P
A
A
NS
E
IHLG
V
L
---
SIF
WG
I
A
M
MI
I
GL
GM
Q
V
K
VL
AL
A
PD
A
TD
V
AM
A
LFS
G
I
FN
I
G
I
G
A
GA
LV
G
N
Q
V
-
S
-
L
HW
S
M
S
M
I
GYV
G
T
V
PA
FAAL
I
W
S
II
I
F
R
R
WPV
TL
fig|386585.9.peg.2242
Escherichia coli O157:H7 str. Sakai (15-391/396)
V
V
T
LA
V
A
AF
I
F
N
TTEF
V
P
V
GLL
SD
IA
QS
F
H
M
QTAQV
G
I
M
LT
I
YA
W
V
V
A
LMSL
PFM
L
MT
S
QVE
RR
KL
LI
C
L
F
V
V
F
IA
SH
VLS
F
LS
W
S
F
TV
L
V
ISRI
GVA
F
A
H
AI
F
WS
I
T
A
S
L
A
IR
M
A
P
A
GK
R
A
Q
A
LS
L
I
AT
G
T
A
LA
M
VLG
L
PLG
R
I
V
GQ
Y
FGWRMTF
F
AI
G
IGA
L
I
T
L
L
C
L
IKL
LP
LLPS
E
H
S
G
S
L
-
K
SLPLL
F
RRPA
LM
SI
Y
L
L
TV
V
V
VT
A
H
Y
T
A
YSYI
E
P
F
V
Q
N
I
A
G
F
S
AN
F
A
TA
L
LLL
L
G
G
A
GI
IG
S
V
I
F
GKL
GN
Q
Y
ASALVS
T
AIA
L
LLV
C
LA
L
L
-
L
--
P
A
A
NS
E
IHLG
V
L
---
SIF
WG
I
A
M
MI
I
GL
GM
Q
V
K
VL
AL
A
PD
A
TD
V
AM
A
LFS
G
I
FN
I
G
I
G
A
GA
LV
G
N
Q
V
-
S
-
L
HW
S
M
S
M
I
GYV
G
T
V
PA
FAAL
I
W
S
II
I
F
R
R
WPV
TL
fig|502346.5.peg.5230
Escherichia coli O157:H7 str. TW14588 (15-391/396)
V
V
T
LA
V
A
AF
I
F
N
TTEF
V
P
V
GLL
SD
IA
QS
F
H
M
QTAQV
G
I
M
LT
I
YA
W
V
V
A
LMSL
PFM
L
MT
S
QVE
RR
KL
LI
C
L
F
V
V
F
IA
SH
VLS
F
LS
W
S
F
TV
L
V
ISRI
GVA
F
A
H
AI
F
WS
I
T
A
S
L
A
IR
M
A
P
A
GK
R
A
Q
A
LS
L
I
AT
G
T
A
LA
M
VLG
L
PLG
R
I
V
GQ
Y
FGWRMTF
F
AI
G
IGA
L
I
T
L
L
C
L
IKL
LP
LLPS
E
H
S
G
S
L
-
K
SLPLL
F
RRPA
LM
SI
Y
L
L
TV
V
V
VT
A
H
Y
T
A
YSYI
E
P
F
V
Q
N
I
A
G
F
S
AN
F
A
TA
L
LLL
L
G
G
A
GI
IG
S
V
I
F
GKL
GN
Q
Y
ASALVS
T
AIA
L
LLV
C
LA
L
L
-
L
--
P
A
A
NS
E
IHLG
V
L
---
SIF
WG
I
A
M
MI
I
GL
GM
Q
V
K
VL
AL
A
PD
A
TD
V
AM
A
LFS
G
I
FN
I
G
I
G
A
GA
LV
G
N
Q
V
-
S
-
L
HW
S
M
S
M
I
GYV
G
T
V
PA
FAAL
I
W
S
II
I
F
R
R
WPV
TL
fig|701177.3.peg.1886
Escherichia coli O55:H7 str. CB9615 (15-391/396)
V
V
T
LA
V
A
AF
I
F
N
TTEF
V
P
V
GLL
SD
IA
QS
F
H
M
QTAQV
G
I
M
LT
I
YA
W
V
V
A
LMSL
PFM
L
MT
S
QVE
RR
KL
LI
C
L
F
V
V
F
IA
SH
VLS
F
LS
W
S
F
TV
L
V
ISRI
GVA
F
A
H
AI
F
WS
I
T
A
S
L
A
IR
M
A
P
A
GK
R
A
Q
A
LS
L
I
AT
G
T
A
LA
M
VLG
L
PLG
R
I
V
GQ
Y
FGWRMTF
F
AI
G
IGA
L
I
T
L
L
C
L
IKL
LP
LLPS
E
H
S
G
S
L
-
K
SLPLL
F
RRPA
LM
SI
Y
L
L
TV
V
V
VT
A
H
Y
T
A
YSYI
E
P
F
V
Q
N
I
A
G
F
S
AN
F
A
TA
L
LLL
L
G
G
A
GI
IG
S
V
I
F
GKL
GN
Q
Y
ASALVS
T
AIA
L
LLV
C
LA
L
L
-
L
--
P
A
A
NS
E
IHLG
V
L
---
SIF
WG
I
A
M
MI
I
GL
GM
Q
V
K
VL
AL
A
PD
A
TD
V
AM
A
LFS
G
I
FN
I
G
I
G
A
GA
LV
G
N
Q
V
-
S
-
L
HW
S
M
S
M
I
GYV
G
T
V
PA
FAAL
I
W
S
II
I
F
R
R
WPV
TL
fig|444454.5.peg.714
Escherichia coli O157:H7 str. EC4024 (10-363/370)
T
V
EF
L
P
V
S
LL
TP
M
A
QD
L
G
I
S
EGV
AG
Q
S
V
T
V
T
A
F
V
A
M
FA
SL
FIT
Q
VI
G
TID
RR
KV
V
I
LF
S
V
L
L
TL
S
C
L
L
V
S
F
A
E
S
F
TL
L
L
LG
R
A
CLG
L
G
L
G
G
F
W
A
M
S
A
S
L
T
MR
L
V
P
A
RT
V
P
K
A
LS
V
I
FG
A
V
SI
A
L
V
I
AA
PLG
S
F
LG
G
I
I
GWR
NV
F
N
A
A
A
VMG
V
L
C
I
I
W
V
WKA
LP
SLPG
EA
A
H
H
K
-
Q
NMFAL
L
K
RP
G
VL
A
G
M
T
A
IF
M
S
FA
G
Q
F
A
F
FT
YI
R
P
V
Y
M
T
M
A
G
F
D
VD
G
L
T
L
V
LL
SF
G
I
A
SF
V
G
T
S
L
S
S
Q
F
LK
R
S
LKVALA
G
APL
V
L
A
L
S
AA
V
L
V
L
--
-
W
G
SD
K
WVAS
A
I
---
AII
WG
F
A
F
AL
V
PV
G
WST
W
I
T
RS
L
AD
Q
AE
K
AG
S
IQV
AVIQ
L
A
N
T
C
GA
AV
GG
V
A
L
DH
LGL
T
SP
L
-
---
-V
I
SG
TLM
L
L
T
A
LLV
fig|749549.3.peg.49
Escherichia coli MS 198-1 (20-393/397)
I
F
A
M
T
L
CV
F
V
L
IA
S
EF
M
P
V
S
LL
TP
I
T
RD
L
G
V
T
EGL
AG
Q
G
I
A
I
SG
A
QA
V
L
T
SL
TLS
T
LA
G
KMN
R
K
FL
L
L
G
M
T
V
L
M
AV
S
G
LI
I
A
L
A
S
SY
LM
Y
M
V
G
R
A
MIG
V
A
I
G
G
F
WS
M
S
A
A
T
A
IR
L
V
P
Q
H
Q
V
T
R
A
L
A
I
F
NA
G
N
A
LA
T
V
V
AA
PLG
S
Y
LG
A
T
V
GWR
GA
FL
C
L
V
PIA
V
V
A
F
I
WQ
CIS
LP
SMDA
NK
S
H
T
SCG
AVFRL
F
S
R
RM
VV
VG
M
I
A
CG
L
F
FM
G
Q
F
A
L
FT
Y
V
R
P
F
L
E
S
V
T
R
V
N
SL
G
L
SS
ILL
I
IG
V
A
GF
IG
T
L
V
V
SAF
LN
R
K
FYPTLM
A
IPG
L
M
A
V
I
AI
G
L
M
L
--
-
T
G
HH
V
WTVS
L
L
---
LGL
WG
ML
A
T
A
A
PT
G
WWT
W
I
A
RT
L
PD
N
AE
A
GG
G
LMV
AVIQ
L
A
I
A
L
G
S
TA
GG
I
V
F
DR
LG
W
Q
S
T
F
-
---
-
A
M
SS
VLL
L
C
AG
V
L
T
F
V
T
ARQ
K
fig|585056.7.peg.508
Escherichia coli UMN026 (20-393/397)
I
F
A
M
T
L
CV
F
V
L
IA
S
EF
M
P
V
S
LL
TP
I
T
RD
L
G
V
T
EGL
AG
Q
G
I
A
I
SG
A
QA
V
L
T
SL
TLS
T
LA
G
KMN
R
K
FL
L
L
G
M
T
V
L
M
AV
S
G
LI
I
A
L
A
S
SY
LM
Y
M
V
G
R
A
MIG
V
A
I
G
G
F
WS
M
S
A
A
T
A
IR
L
V
P
Q
H
Q
V
T
R
A
L
A
I
F
NA
G
N
A
LA
T
V
V
AA
PLG
S
Y
LG
A
T
V
GWR
GA
FL
C
L
V
PIA
V
V
A
F
I
WQ
CIS
LP
SMDA
NK
S
H
T
SCG
AVFRL
F
S
R
RM
VV
VG
M
I
A
CG
L
F
FM
G
Q
F
A
L
FT
Y
V
R
P
F
L
E
S
V
T
R
V
N
SL
G
L
SS
ILL
I
IG
V
A
GF
IG
T
L
V
V
SAF
LN
R
K
FYPTLM
A
IPG
L
M
A
V
I
AI
G
L
M
L
--
-
T
G
HH
V
WTVS
L
L
---
LGL
WG
ML
A
T
A
A
PT
G
WWT
W
I
A
RT
L
PD
N
AE
A
GG
G
LMV
AVIQ
L
A
I
A
L
G
S
TA
GG
I
V
F
DR
LG
W
Q
S
T
F
-
---
-
A
M
SS
VLL
L
C
AG
V
L
T
F
V
T
ARQ
K
fig|656380.3.peg.896
Escherichia coli FVEC1412 (1-371/375)
M
T
L
CV
F
V
L
IA
S
EF
M
P
V
S
LL
TP
I
T
RD
L
G
V
T
EGL
AG
Q
G
I
A
I
SG
A
QA
V
L
T
SL
TLS
T
LA
G
KMN
R
K
FL
L
L
G
M
T
V
L
M
AV
S
G
LI
I
A
L
A
S
SY
LM
Y
M
V
G
R
A
MIG
V
A
I
G
G
F
WS
M
S
A
A
T
A
IR
L
V
P
Q
H
Q
V
T
R
A
L
A
I
F
NA
G
N
A
LA
T
V
V
AA
PLG
S
Y
LG
A
T
V
GWR
GA
FL
C
L
V
PIA
V
V
A
F
I
WQ
CIS
LP
SMDA
NK
S
H
T
SCG
AVFRL
F
S
R
RM
VV
VG
M
I
A
CG
L
F
FM
G
Q
F
A
L
FT
Y
V
R
P
F
L
E
S
V
T
R
V
N
SL
G
L
SS
ILL
I
IG
V
A
GF
IG
T
L
V
V
SAF
LN
R
K
FYPTLM
A
IPG
L
M
A
V
I
AI
G
L
M
L
--
-
T
G
HH
V
WTVS
L
L
---
LGL
WG
ML
A
T
A
A
PT
G
WWT
W
I
A
RT
L
PD
N
AE
A
GG
G
LMV
AVIQ
L
A
I
A
L
G
S
TA
GG
I
V
F
DR
LG
W
Q
S
T
F
-
---
-
A
M
SS
VLL
L
C
AG
V
L
T
F
V
T
ARQ
K
fig|216592.1.peg.4956
Escherichia coli 042 (20-393/397)
I
F
A
M
T
L
CV
F
V
L
IA
S
EF
M
P
V
S
LL
TP
I
T
RD
L
G
V
T
EGL
AG
Q
G
I
A
I
SG
A
LA
V
L
T
SL
TLS
T
LA
G
KMN
R
K
FL
L
L
G
M
T
V
L
M
AV
S
G
LI
I
A
L
A
S
SY
LM
Y
M
V
G
R
A
MIG
V
A
I
G
G
F
WS
M
S
A
A
T
A
IR
L
V
P
Q
H
Q
V
T
R
A
L
A
I
F
NA
G
N
A
LA
TA
V
AA
PLG
S
Y
LG
A
K
V
GWR
GA
FL
C
L
V
PIA
V
V
A
F
I
WQ
CIS
LP
SMDA
NK
S
H
T
SCG
AVFRL
F
S
R
RM
VV
VG
M
I
A
CG
L
F
FM
G
Q
F
A
L
FT
Y
V
R
P
F
L
E
S
V
T
R
V
N
SL
G
L
SS
ILL
I
IG
V
A
GF
IG
T
L
V
V
SAF
LN
R
K
FYPTLM
A
IPG
L
M
A
V
I
AI
G
L
M
L
--
-
T
G
HH
V
WTVS
L
L
---
LGL
WG
ML
A
T
A
A
PT
G
WWT
W
I
A
RT
L
PD
N
AE
A
GG
G
LMV
AVIQ
L
A
I
A
L
G
S
TA
GG
I
V
F
DR
LG
W
Q
S
T
F
-
---
-
A
M
SS
VLL
L
C
AG
V
L
T
F
V
T
ARQ
K
fig|216592.3.peg.330
Escherichia coli 042 (1-371/375)
M
T
L
CV
F
V
L
IA
S
EF
M
P
V
S
LL
TP
I
T
RD
L
G
V
T
EGL
AG
Q
G
I
A
I
SG
A
LA
V
L
T
SL
TLS
T
LA
G
KMN
R
K
FL
L
L
G
M
T
V
L
M
AV
S
G
LI
I
A
L
A
S
SY
LM
Y
M
V
G
R
A
MIG
V
A
I
G
G
F
WS
M
S
A
A
T
A
IR
L
V
P
Q
H
Q
V
T
R
A
L
A
I
F
NA
G
N
A
LA
TA
V
AA
PLG
S
Y
LG
A
K
V
GWR
GA
FL
C
L
V
PIA
V
V
A
F
I
WQ
CIS
LP
SMDA
NK
S
H
T
SCG
AVFRL
F
S
R
RM
VV
VG
M
I
A
CG
L
F
FM
G
Q
F
A
L
FT
Y
V
R
P
F
L
E
S
V
T
R
V
N
SL
G
L
SS
ILL
I
IG
V
A
GF
IG
T
L
V
V
SAF
LN
R
K
FYPTLM
A
IPG
L
M
A
V
I
AI
G
L
M
L
--
-
T
G
HH
V
WTVS
L
L
---
LGL
WG
ML
A
T
A
A
PT
G
WWT
W
I
A
RT
L
PD
N
AE
A
GG
G
LMV
AVIQ
L
A
I
A
L
G
S
TA
GG
I
V
F
DR
LG
W
Q
S
T
F
-
---
-
A
M
SS
VLL
L
C
AG
V
L
T
F
V
T
ARQ
K
fig|749531.3.peg.1386
Escherichia coli MS 69-1 (20-393/397)
I
F
A
M
T
L
CV
F
V
L
IA
S
EF
M
P
V
S
LL
TP
I
T
RD
L
G
V
T
EGL
AG
Q
G
I
A
I
SG
A
LA
V
L
T
SL
TLS
T
LA
G
KMN
R
K
FL
L
L
G
M
T
V
L
M
AV
S
G
LI
I
A
L
A
S
SY
LM
Y
M
V
G
R
A
MIG
V
A
I
G
G
F
WS
M
S
A
A
T
A
IR
L
V
P
Q
H
Q
V
T
R
A
L
A
I
F
NA
G
N
A
LA
T
V
V
AA
PLG
S
Y
LG
A
T
V
GWR
GA
FL
C
L
V
PIA
V
V
A
F
I
WQ
CIS
LP
SMDA
NK
S
H
T
SCG
AVFRL
F
S
R
RM
VV
VG
M
I
A
CC
L
F
FM
G
Q
F
A
L
FT
Y
V
R
P
F
L
E
S
V
T
R
V
N
SL
G
L
S
L
ILL
I
IG
V
A
GF
IG
T
L
V
V
SAF
LN
R
K
FYPTLM
A
IPG
L
M
A
V
I
AI
G
L
M
L
--
-
T
G
HH
V
WTVS
L
L
---
LGL
WG
ML
A
T
A
A
PT
G
WWT
W
I
A
RT
L
PD
N
AE
A
GG
G
LMV
AVIQ
L
S
I
A
L
G
S
TA
GG
I
V
F
DR
LG
W
Q
S
T
F
-
---
-
A
M
SS
VLL
L
C
AG
V
L
T
F
V
T
ARQ
K
fig|656419.3.peg.447
Escherichia coli M718 (20-393/397)
I
F
A
M
T
L
CV
F
V
L
IA
S
EF
M
P
V
S
LL
TP
I
T
RD
L
G
V
T
EGL
AG
Q
G
I
A
I
SG
A
LA
V
L
T
SL
TLS
T
LA
G
KMN
R
K
FL
L
L
G
M
T
V
L
M
AV
S
G
LI
I
A
L
A
S
N
Y
LM
Y
M
V
G
R
A
MIG
V
A
I
G
G
F
WS
M
S
A
A
T
A
IR
L
V
P
Q
H
Q
V
T
R
A
L
A
I
F
NA
G
N
A
LA
T
V
V
AA
PLG
S
Y
LG
A
T
V
GWR
GA
FL
C
L
V
PIA
V
V
A
F
I
WQ
CIS
LP
SMDA
NK
S
H
A
SFG
AVFRL
F
S
R
RM
VV
VG
M
I
A
CG
L
F
FM
G
Q
F
A
L
FT
Y
V
R
P
F
L
E
S
V
T
R
V
N
SL
G
L
S
L
ILL
I
IG
V
A
GF
IG
T
L
V
V
STF
LN
R
K
FYPTLM
A
IPG
L
M
A
V
I
AI
G
L
M
L
--
-
T
G
HH
V
WTVS
L
L
---
LGL
WG
ML
A
T
A
A
PT
G
WWT
W
I
A
RT
L
PD
N
AE
A
GG
G
LMV
AVIQ
L
S
I
A
L
G
S
TA
GG
I
V
F
DR
LG
W
Q
S
T
F
-
---
-
A
M
SS
VLL
L
C
AG
V
L
T
F
V
T
ARQ
K
fig|83334.1.peg.394
Escherichia coli O157:H7 (20-393/397)
I
F
A
M
T
L
CV
F
V
L
IA
S
EF
M
P
V
S
LL
TP
IA
RD
L
G
V
T
EGL
AG
R
G
I
A
I
SG
A
LA
V
L
T
SL
TLS
T
LA
G
KMN
R
K
FL
L
L
G
M
T
V
L
M
AV
S
G
LI
I
A
L
A
T
SY
LM
Y
M
V
G
R
A
MIG
V
A
I
G
G
F
WS
M
S
A
A
T
A
IR
L
V
P
Q
H
Q
V
T
R
A
L
A
I
F
NA
G
N
A
LA
T
V
V
AA
PLG
S
Y
LG
A
T
V
GWR
GA
FL
C
L
V
PMA
V
V
A
F
I
WQ
CIS
LP
SMDA
NK
S
H
T
SCG
AVFRL
F
S
R
RM
VV
VG
M
I
A
CG
L
F
FM
G
Q
F
A
L
FT
Y
V
R
P
F
L
E
S
V
T
R
V
N
SL
G
L
S
L
ILL
I
IG
V
A
GF
IG
T
L
V
V
SIF
LN
R
K
CYPTLM
A
IPG
L
M
A
V
I
AI
G
L
M
L
--
-
T
G
HH
V
WMVS
L
L
---
LGL
WG
ML
A
T
A
A
PT
G
WWT
W
I
A
RT
L
PD
N
AE
A
GG
G
LMV
AVIQ
L
S
I
A
L
G
S
TA
GG
I
V
F
DR
LG
W
Q
S
T
F
-
---
-
A
M
SS
VLL
L
C
AG
V
L
T
F
V
T
ARQ
K
fig|155864.1.peg.307
Escherichia coli O157:H7 EDL933 (20-393/397)
I
F
A
M
T
L
CV
F
V
L
IA
S
EF
M
P
V
S
LL
TP
IA
RD
L
G
V
T
EGL
AG
R
G
I
A
I
SG
A
LA
V
L
T
SL
TLS
T
LA
G
KMN
R
K
FL
L
L
G
M
T
V
L
M
AV
S
G
LI
I
A
L
A
T
SY
LM
Y
M
V
G
R
A
MIG
V
A
I
G
G
F
WS
M
S
A
A
T
A
IR
L
V
P
Q
H
Q
V
T
R
A
L
A
I
F
NA
G
N
A
LA
T
V
V
AA
PLG
S
Y
LG
A
T
V
GWR
GA
FL
C
L
V
PMA
V
V
A
F
I
WQ
CIS
LP
SMDA
NK
S
H
T
SCG
AVFRL
F
S
R
RM
VV
VG
M
I
A
CG
L
F
FM
G
Q
F
A
L
FT
Y
V
R
P
F
L
E
S
V
T
R
V
N
SL
G
L
S
L
ILL
I
IG
V
A
GF
IG
T
L
V
V
SIF
LN
R
K
CYPTLM
A
IPG
L
M
A
V
I
AI
G
L
M
L
--
-
T
G
HH
V
WMVS
L
L
---
LGL
WG
ML
A
T
A
A
PT
G
WWT
W
I
A
RT
L
PD
N
AE
A
GG
G
LMV
AVIQ
L
S
I
A
L
G
S
TA
GG
I
V
F
DR
LG
W
Q
S
T
F
-
---
-
A
M
SS
VLL
L
C
AG
V
L
T
F
V
T
ARQ
K
fig|155864.8.peg.305
Escherichia coli O157:H7 EDL933 (20-393/397)
I
F
A
M
T
L
CV
F
V
L
IA
S
EF
M
P
V
S
LL
TP
IA
RD
L
G
V
T
EGL
AG
R
G
I
A
I
SG
A
LA
V
L
T
SL
TLS
T
LA
G
KMN
R
K
FL
L
L
G
M
T
V
L
M
AV
S
G
LI
I
A
L
A
T
SY
LM
Y
M
V
G
R
A
MIG
V
A
I
G
G
F
WS
M
S
A
A
T
A
IR
L
V
P
Q
H
Q
V
T
R
A
L
A
I
F
NA
G
N
A
LA
T
V
V
AA
PLG
S
Y
LG
A
T
V
GWR
GA
FL
C
L
V
PMA
V
V
A
F
I
WQ
CIS
LP
SMDA
NK
S
H
T
SCG
AVFRL
F
S
R
RM
VV
VG
M
I
A
CG
L
F
FM
G
Q
F
A
L
FT
Y
V
R
P
F
L
E
S
V
T
R
V
N
SL
G
L
S
L
ILL
I
IG
V
A
GF
IG
T
L
V
V
SIF
LN
R
K
CYPTLM
A
IPG
L
M
A
V
I
AI
G
L
M
L
--
-
T
G
HH
V
WMVS
L
L
---
LGL
WG
ML
A
T
A
A
PT
G
WWT
W
I
A
RT
L
PD
N
AE
A
GG
G
LMV
AVIQ
L
S
I
A
L
G
S
TA
GG
I
V
F
DR
LG
W
Q
S
T
F
-
---
-
A
M
SS
VLL
L
C
AG
V
L
T
F
V
T
ARQ
K
fig|478006.5.peg.2397
Escherichia coli O157:H7 str. EC4501 (20-393/397)
I
F
A
M
T
L
CV
F
V
L
IA
S
EF
M
P
V
S
LL
TP
IA
RD
L
G
V
T
EGL
AG
R
G
I
A
I
SG
A
LA
V
L
T
SL
TLS
T
LA
G
KMN
R
K
FL
L
L
G
M
T
V
L
M
AV
S
G
LI
I
A
L
A
T
SY
LM
Y
M
V
G
R
A
MIG
V
A
I
G
G
F
WS
M
S
A
A
T
A
IR
L
V
P
Q
H
Q
V
T
R
A
L
A
I
F
NA
G
N
A
LA
T
V
V
AA
PLG
S
Y
LG
A
T
V
GWR
GA
FL
C
L
V
PMA
V
V
A
F
I
WQ
CIS
LP
SMDA
NK
S
H
T
SCG
AVFRL
F
S
R
RM
VV
VG
M
I
A
CG
L
F
FM
G
Q
F
A
L
FT
Y
V
R
P
F
L
E
S
V
T
R
V
N
SL
G
L
S
L
ILL
I
IG
V
A
GF
IG
T
L
V
V
SIF
LN
R
K
CYPTLM
A
IPG
L
M
A
V
I
AI
G
L
M
L
--
-
T
G
HH
V
WMVS
L
L
---
LGL
WG
ML
A
T
A
A
PT
G
WWT
W
I
A
RT
L
PD
N
AE
A
GG
G
LMV
AVIQ
L
S
I
A
L
G
S
TA
GG
I
V
F
DR
LG
W
Q
S
T
F
-
---
-
A
M
SS
VLL
L
C
AG
V
L
T
F
V
T
ARQ
K
fig|386585.9.peg.406
Escherichia coli O157:H7 str. Sakai (20-393/397)
I
F
A
M
T
L
CV
F
V
L
IA
S
EF
M
P
V
S
LL
TP
IA
RD
L
G
V
T
EGL
AG
R
G
I
A
I
SG
A
LA
V
L
T
SL
TLS
T
LA
G
KMN
R
K
FL
L
L
G
M
T
V
L
M
AV
S
G
LI
I
A
L
A
T
SY
LM
Y
M
V
G
R
A
MIG
V
A
I
G
G
F
WS
M
S
A
A
T
A
IR
L
V
P
Q
H
Q
V
T
R
A
L
A
I
F
NA
G
N
A
LA
T
V
V
AA
PLG
S
Y
LG
A
T
V
GWR
GA
FL
C
L
V
PMA
V
V
A
F
I
WQ
CIS
LP
SMDA
NK
S
H
T
SCG
AVFRL
F
S
R
RM
VV
VG
M
I
A
CG
L
F
FM
G
Q
F
A
L
FT
Y
V
R
P
F
L
E
S
V
T
R
V
N
SL
G
L
S
L
ILL
I
IG
V
A
GF
IG
T
L
V
V
SIF
LN
R
K
CYPTLM
A
IPG
L
M
A
V
I
AI
G
L
M
L
--
-
T
G
HH
V
WMVS
L
L
---
LGL
WG
ML
A
T
A
A
PT
G
WWT
W
I
A
RT
L
PD
N
AE
A
GG
G
LMV
AVIQ
L
S
I
A
L
G
S
TA
GG
I
V
F
DR
LG
W
Q
S
T
F
-
---
-
A
M
SS
VLL
L
C
AG
V
L
T
F
V
T
ARQ
K
fig|502346.5.peg.956
Escherichia coli O157:H7 str. TW14588 (20-393/397)
I
F
A
M
T
L
CV
F
V
L
IA
S
EF
M
P
V
S
LL
TP
IA
RD
L
G
V
T
EGL
AG
R
G
I
A
I
SG
A
LA
V
L
T
SL
TLS
T
LA
G
KMN
R
K
FL
L
L
G
M
T
V
L
M
AV
S
G
LI
I
A
L
A
T
SY
LM
Y
M
V
G
R
A
MIG
V
A
I
G
G
F
WS
M
S
A
A
T
A
IR
L
V
P
Q
H
Q
V
T
R
A
L
A
I
F
NA
G
N
A
LA
T
V
V
AA
PLG
S
Y
LG
A
T
V
GWR
GA
FL
C
L
V
PMA
V
V
A
F
I
WQ
CIS
LP
SMDA
NK
S
H
T
SCG
AVFRL
F
S
R
RM
VV
VG
M
I
A
CG
L
F
FM
G
Q
F
A
L
FT
Y
V
R
P
F
L
E
S
V
T
R
V
N
SL
G
L
S
L
ILL
I
IG
V
A
GF
IG
T
L
V
V
SIF
LN
R
K
CYPTLM
A
IPG
L
M
A
V
I
AI
G
L
M
L
--
-
T
G
HH
V
WMVS
L
L
---
LGL
WG
ML
A
T
A
A
PT
G
WWT
W
I
A
RT
L
PD
N
AE
A
GG
G
LMV
AVIQ
L
S
I
A
L
G
S
TA
GG
I
V
F
DR
LG
W
Q
S
T
F
-
---
-
A
M
SS
VLL
L
C
AG
V
L
T
F
V
T
ARQ
K
fig|656437.3.peg.341
Escherichia coli TA143 (20-393/397)
I
F
A
M
T
L
CV
F
V
L
IA
S
EF
M
P
V
S
LL
TP
I
T
RD
L
G
V
T
EGL
AG
Q
G
I
A
I
SG
A
LA
V
M
T
SL
TLS
T
LA
G
KMN
R
K
FL
L
L
G
M
T
V
L
M
AV
S
G
LI
I
A
L
A
S
SY
LM
Y
M
V
G
R
A
MIG
V
A
I
G
G
F
WS
M
S
A
A
T
A
IR
L
V
P
Q
H
Q
V
T
R
A
L
A
I
F
NA
G
N
A
LA
T
V
V
AA
PLG
S
Y
LG
A
T
V
GWR
GA
FL
C
L
V
PIA
V
V
A
F
I
WQ
CIS
LP
SMDA
NK
S
H
A
SFG
AVFRL
F
S
R
RM
VV
VG
M
I
A
CG
L
F
FM
G
Q
F
A
L
FT
Y
V
R
P
F
L
E
S
V
T
R
V
N
SL
G
L
S
L
ILL
I
IG
V
A
GF
IG
T
L
V
V
SAF
LN
R
K
FYPTLM
A
IPG
L
M
A
V
I
AI
G
L
M
L
--
-
T
G
HH
V
WTVS
L
L
---
LGL
WG
ML
A
T
A
A
PT
G
WWA
W
I
A
RT
L
PD
N
AE
A
GG
G
LMV
AVIQ
L
A
I
A
L
GA
TA
GG
I
V
F
DR
LG
W
Q
S
T
F
-
---
-
A
M
SS
VLL
L
C
AG
V
L
T
F
V
T
ARQ
K
fig|701177.3.peg.360
Escherichia coli O55:H7 str. CB9615 (20-393/397)
I
F
A
M
T
L
CV
F
V
L
IA
S
EF
M
P
V
S
LL
TP
IA
RD
L
G
V
T
EGL
AG
R
G
I
A
I
SG
A
LA
V
L
T
SL
TLS
T
LA
G
KMN
R
K
FL
L
L
G
M
T
V
L
M
AV
S
G
LI
I
A
L
A
T
SY
LM
Y
M
V
G
R
A
MIG
V
A
I
G
G
F
WS
M
S
A
A
T
A
IR
L
V
P
Q
H
Q
V
T
R
A
L
A
I
F
NA
G
N
A
LA
T
V
V
AA
PLG
S
Y
LG
A
T
V
GWR
GA
FL
C
L
V
PMA
V
V
A
F
I
WQ
CIS
LP
SMDA
NK
S
H
T
SCG
AVFRL
F
S
R
RM
VV
VG
M
I
A
CG
L
F
FM
G
Q
F
A
L
FT
Y
V
R
P
F
L
E
S
V
T
R
V
N
SL
G
L
S
L
ILL
I
IG
V
A
GF
IG
T
L
V
V
STF
LN
R
K
FYPTLM
A
IPG
L
M
A
V
I
AI
G
L
M
L
--
-
T
G
HH
V
WMVS
L
L
---
LGL
WG
ML
A
T
A
A
PT
G
WWT
W
I
A
RT
L
LD
N
AE
A
GG
G
LMV
AVIQ
L
S
I
A
L
G
S
TA
GG
I
V
F
DR
LG
W
Q
S
T
F
-
---
-
A
M
SS
VLL
L
C
AG
V
L
T
F
V
T
ARQ
K
fig|562.374.peg.5891
Escherichia coli 536A (20-393/397)
I
F
A
M
T
L
CV
F
V
L
IA
S
EF
M
P
V
S
LL
TP
IA
RD
L
G
V
T
EGL
AG
R
G
I
A
I
SG
A
LA
V
L
T
SL
TLS
T
LA
G
KMN
R
K
FL
L
L
G
M
T
V
L
M
AV
S
G
LI
I
A
L
A
T
SY
LM
Y
M
V
G
R
A
MIG
V
A
I
G
G
F
WS
M
S
A
A
T
A
IR
L
V
P
Q
H
Q
V
T
R
A
L
A
I
F
NA
G
N
A
LA
T
V
V
AA
PLG
S
Y
LG
A
T
V
GWR
GA
FL
C
L
V
PMA
V
V
A
F
I
WQ
CIS
LP
SMDA
NK
S
H
T
SCG
AVFRL
F
S
R
RM
VV
VG
M
I
A
CG
L
F
FM
G
Q
F
A
L
FT
Y
V
R
P
F
L
E
S
V
T
R
V
N
SL
G
L
S
L
ILL
I
IG
V
A
GF
IG
T
L
V
V
SIF
LN
R
K
FYPTLM
A
IPG
L
M
A
V
I
AI
G
L
M
L
--
-
T
G
HH
V
WMVS
L
L
---
LGL
WG
ML
A
T
A
A
PT
G
WWT
W
I
A
RT
L
PD
N
AE
A
GG
G
LMV
AVIQ
L
S
I
A
L
G
S
TA
GG
I
V
F
DR
LG
W
Q
S
T
F
-
---
-
A
M
SS
VLL
L
C
AG
V
L
T
F
V
T
ARQ
K
fig|444454.5.peg.4774
Escherichia coli O157:H7 str. EC4024 (20-393/397)
I
F
A
M
T
L
CV
F
V
L
IA
S
EF
M
P
V
S
LL
TP
IA
RD
L
G
V
T
EGL
AG
R
G
I
A
I
SG
A
LA
V
L
T
SL
TLS
T
LA
G
KMN
R
K
FL
L
L
G
M
T
V
L
M
AV
S
G
LI
I
A
L
A
T
SY
LM
Y
M
V
G
R
A
MIG
V
A
I
G
G
F
WS
M
S
A
A
T
A
IR
L
V
P
Q
H
Q
V
T
R
A
L
A
I
F
NA
G
N
A
LA
T
V
V
AA
PLG
S
Y
LG
A
T
V
GWR
GA
FL
C
L
V
PMA
V
V
A
F
I
WQ
CIS
LP
SMDA
NK
S
H
T
SCG
AVFRL
F
S
R
RM
VV
VG
M
I
A
CG
L
F
FM
G
Q
F
A
L
FT
Y
V
R
P
F
L
E
S
V
T
R
V
N
SL
G
L
S
L
ILL
I
IG
V
A
GF
IG
T
L
V
V
SIF
LN
R
K
FYPTLM
A
IPG
L
M
A
V
I
AI
G
L
M
L
--
-
T
G
HH
V
WMVS
L
L
---
LGL
WG
ML
A
T
A
A
PT
G
WWT
W
I
A
RT
L
PD
N
AE
A
GG
G
LMV
AVIQ
L
S
I
A
L
G
S
TA
GG
I
V
F
DR
LG
W
Q
S
T
F
-
---
-
A
M
SS
VLL
L
C
AG
V
L
T
F
V
T
ARQ
K
fig|444449.5.peg.5115
Escherichia coli O157:H7 str. EC4042 (20-393/397)
I
F
A
M
T
L
CV
F
V
L
IA
S
EF
M
P
V
S
LL
TP
IA
RD
L
G
V
T
EGL
AG
R
G
I
A
I
SG
A
LA
V
L
T
SL
TLS
T
LA
G
KMN
R
K
FL
L
L
G
M
T
V
L
M
AV
S
G
LI
I
A
L
A
T
SY
LM
Y
M
V
G
R
A
MIG
V
A
I
G
G
F
WS
M
S
A
A
T
A
IR
L
V
P
Q
H
Q
V
T
R
A
L
A
I
F
NA
G
N
A
LA
T
V
V
AA
PLG
S
Y
LG
A
T
V
GWR
GA
FL
C
L
V
PMA
V
V
A
F
I
WQ
CIS
LP
SMDA
NK
S
H
T
SCG
AVFRL
F
S
R
RM
VV
VG
M
I
A
CG
L
F
FM
G
Q
F
A
L
FT
Y
V
R
P
F
L
E
S
V
T
R
V
N
SL
G
L
S
L
ILL
I
IG
V
A
GF
IG
T
L
V
V
SIF
LN
R
K
FYPTLM
A
IPG
L
M
A
V
I
AI
G
L
M
L
--
-
T
G
HH
V
WMVS
L
L
---
LGL
WG
ML
A
T
A
A
PT
G
WWT
W
I
A
RT
L
PD
N
AE
A
GG
G
LMV
AVIQ
L
S
I
A
L
G
S
TA
GG
I
V
F
DR
LG
W
Q
S
T
F
-
---
-
A
M
SS
VLL
L
C
AG
V
L
T
F
V
T
ARQ
K
fig|444448.5.peg.2990
Escherichia coli O157:H7 str. EC4045 (20-393/397)
I
F
A
M
T
L
CV
F
V
L
IA
S
EF
M
P
V
S
LL
TP
IA
RD
L
G
V
T
EGL
AG
R
G
I
A
I
SG
A
LA
V
L
T
SL
TLS
T
LA
G
KMN
R
K
FL
L
L
G
M
T
V
L
M
AV
S
G
LI
I
A
L
A
T
SY
LM
Y
M
V
G
R
A
MIG
V
A
I
G
G
F
WS
M
S
A
A
T
A
IR
L
V
P
Q
H
Q
V
T
R
A
L
A
I
F
NA
G
N
A
LA
T
V
V
AA
PLG
S
Y
LG
A
T
V
GWR
GA
FL
C
L
V
PMA
V
V
A
F
I
WQ
CIS
LP
SMDA
NK
S
H
T
SCG
AVFRL
F
S
R
RM
VV
VG
M
I
A
CG
L
F
FM
G
Q
F
A
L
FT
Y
V
R
P
F
L
E
S
V
T
R
V
N
SL
G
L
S
L
ILL
I
IG
V
A
GF
IG
T
L
V
V
SIF
LN
R
K
FYPTLM
A
IPG
L
M
A
V
I
AI
G
L
M
L
--
-
T
G
HH
V
WMVS
L
L
---
LGL
WG
ML
A
T
A
A
PT
G
WWT
W
I
A
RT
L
PD
N
AE
A
GG
G
LMV
AVIQ
L
S
I
A
L
G
S
TA
GG
I
V
F
DR
LG
W
Q
S
T
F
-
---
-
A
M
SS
VLL
L
C
AG
V
L
T
F
V
T
ARQ
K
fig|444453.5.peg.3962
Escherichia coli O157:H7 str. EC4076 (20-393/397)
I
F
A
M
T
L
CV
F
V
L
IA
S
EF
M
P
V
S
LL
TP
IA
RD
L
G
V
T
EGL
AG
R
G
I
A
I
SG
A
LA
V
L
T
SL
TLS
T
LA
G
KMN
R
K
FL
L
L
G
M
T
V
L
M
AV
S
G
LI
I
A
L
A
T
SY
LM
Y
M
V
G
R
A
MIG
V
A
I
G
G
F
WS
M
S
A
A
T
A
IR
L
V
P
Q
H
Q
V
T
R
A
L
A
I
F
NA
G
N
A
LA
T
V
V
AA
PLG
S
Y
LG
A
T
V
GWR
GA
FL
C
L
V
PMA
V
V
A
F
I
WQ
CIS
LP
SMDA
NK
S
H
T
SCG
AVFRL
F
S
R
RM
VV
VG
M
I
A
CG
L
F
FM
G
Q
F
A
L
FT
Y
V
R
P
F
L
E
S
V
T
R
V
N
SL
G
L
S
L
ILL
I
IG
V
A
GF
IG
T
L
V
V
SIF
LN
R
K
FYPTLM
A
IPG
L
M
A
V
I
AI
G
L
M
L
--
-
T
G
HH
V
WMVS
L
L
---
LGL
WG
ML
A
T
A
A
PT
G
WWT
W
I
A
RT
L
PD
N
AE
A
GG
G
LMV
AVIQ
L
S
I
A
L
G
S
TA
GG
I
V
F
DR
LG
W
Q
S
T
F
-
---
-
A
M
SS
VLL
L
C
AG
V
L
T
F
V
T
ARQ
K
fig|444452.5.peg.2155
Escherichia coli O157:H7 str. EC4113 (20-393/397)
I
F
A
M
T
L
CV
F
V
L
IA
S
EF
M
P
V
S
LL
TP
IA
RD
L
G
V
T
EGL
AG
R
G
I
A
I
SG
A
LA
V
L
T
SL
TLS
T
LA
G
KMN
R
K
FL
L
L
G
M
T
V
L
M
AV
S
G
LI
I
A
L
A
T
SY
LM
Y
M
V
G
R
A
MIG
V
A
I
G
G
F
WS
M
S
A
A
T
A
IR
L
V
P
Q
H
Q
V
T
R
A
L
A
I
F
NA
G
N
A
LA
T
V
V
AA
PLG
S
Y
LG
A
T
V
GWR
GA
FL
C
L
V
PMA
V
V
A
F
I
WQ
CIS
LP
SMDA
NK
S
H
T
SCG
AVFRL
F
S
R
RM
VV
VG
M
I
A
CG
L
F
FM
G
Q
F
A
L
FT
Y
V
R
P
F
L
E
S
V
T
R
V
N
SL
G
L
S
L
ILL
I
IG
V
A
GF
IG
T
L
V
V
SIF
LN
R
K
FYPTLM
A
IPG
L
M
A
V
I
AI
G
L
M
L
--
-
T
G
HH
V
WMVS
L
L
---
LGL
WG
ML
A
T
A
A
PT
G
WWT
W
I
A
RT
L
PD
N
AE
A
GG
G
LMV
AVIQ
L
S
I
A
L
G
S
TA
GG
I
V
F
DR
LG
W
Q
S
T
F
-
---
-
A
M
SS
VLL
L
C
AG
V
L
T
F
V
T
ARQ
K
fig|444450.8.peg.452
Escherichia coli O157:H7 str. EC4115 (20-393/397)
I
F
A
M
T
L
CV
F
V
L
IA
S
EF
M
P
V
S
LL
TP
IA
RD
L
G
V
T
EGL
AG
R
G
I
A
I
SG
A
LA
V
L
T
SL
TLS
T
LA
G
KMN
R
K
FL
L
L
G
M
T
V
L
M
AV
S
G
LI
I
A
L
A
T
SY
LM
Y
M
V
G
R
A
MIG
V
A
I
G
G
F
WS
M
S
A
A
T
A
IR
L
V
P
Q
H
Q
V
T
R
A
L
A
I
F
NA
G
N
A
LA
T
V
V
AA
PLG
S
Y
LG
A
T
V
GWR
GA
FL
C
L
V
PMA
V
V
A
F
I
WQ
CIS
LP
SMDA
NK
S
H
T
SCG
AVFRL
F
S
R
RM
VV
VG
M
I
A
CG
L
F
FM
G
Q
F
A
L
FT
Y
V
R
P
F
L
E
S
V
T
R
V
N
SL
G
L
S
L
ILL
I
IG
V
A
GF
IG
T
L
V
V
SIF
LN
R
K
FYPTLM
A
IPG
L
M
A
V
I
AI
G
L
M
L
--
-
T
G
HH
V
WMVS
L
L
---
LGL
WG
ML
A
T
A
A
PT
G
WWT
W
I
A
RT
L
PD
N
AE
A
GG
G
LMV
AVIQ
L
S
I
A
L
G
S
TA
GG
I
V
F
DR
LG
W
Q
S
T
F
-
---
-
A
M
SS
VLL
L
C
AG
V
L
T
F
V
T
ARQ
K
fig|444451.5.peg.3012
Escherichia coli O157:H7 str. EC4196 (20-393/397)
I
F
A
M
T
L
CV
F
V
L
IA
S
EF
M
P
V
S
LL
TP
IA
RD
L
G
V
T
EGL
AG
R
G
I
A
I
SG
A
LA
V
L
T
SL
TLS
T
LA
G
KMN
R
K
FL
L
L
G
M
T
V
L
M
AV
S
G
LI
I
A
L
A
T
SY
LM
Y
M
V
G
R
A
MIG
V
A
I
G
G
F
WS
M
S
A
A
T
A
IR
L
V
P
Q
H
Q
V
T
R
A
L
A
I
F
NA
G
N
A
LA
T
V
V
AA
PLG
S
Y
LG
A
T
V
GWR
GA
FL
C
L
V
PMA
V
V
A
F
I
WQ
CIS
LP
SMDA
NK
S
H
T
SCG
AVFRL
F
S
R
RM
VV
VG
M
I
A
CG
L
F
FM
G
Q
F
A
L
FT
Y
V
R
P
F
L
E
S
V
T
R
V
N
SL
G
L
S
L
ILL
I
IG
V
A
GF
IG
T
L
V
V
SIF
LN
R
K
FYPTLM
A
IPG
L
M
A
V
I
AI
G
L
M
L
--
-
T
G
HH
V
WMVS
L
L
---
LGL
WG
ML
A
T
A
A
PT
G
WWT
W
I
A
RT
L
PD
N
AE
A
GG
G
LMV
AVIQ
L
S
I
A
L
G
S
TA
GG
I
V
F
DR
LG
W
Q
S
T
F
-
---
-
A
M
SS
VLL
L
C
AG
V
L
T
F
V
T
ARQ
K
fig|478007.5.peg.2522
Escherichia coli O157:H7 str. EC508 (20-393/397)
I
F
A
M
T
L
CV
F
V
L
IA
S
EF
M
P
V
S
LL
TP
IA
RD
L
G
V
T
EGL
AG
R
G
I
A
I
SG
A
LA
V
L
T
SL
TLS
T
LA
G
KMN
R
K
FL
L
L
G
M
T
V
L
M
AV
S
G
LI
I
A
L
A
T
SY
LM
Y
M
V
G
R
A
MIG
V
A
I
G
G
F
WS
M
S
A
A
T
A
IR
L
V
P
Q
H
Q
V
T
R
A
L
A
I
F
NA
G
N
A
LA
T
V
V
AA
PLG
S
Y
LG
A
T
V
GWR
GA
FL
C
L
V
PMA
V
V
A
F
I
WQ
CIS
LP
SMDA
NK
S
H
T
SCG
AVFRL
F
S
R
RM
VV
VG
M
I
A
CG
L
F
FM
G
Q
F
A
L
FT
Y
V
R
P
F
L
E
S
V
T
R
V
N
SL
G
L
S
L
ILL
I
IG
V
A
GF
IG
T
L
V
V
SIF
LN
R
K
FYPTLM
A
IPG
L
M
A
V
I
AI
G
L
M
L
--
-
T
G
HH
V
WMVS
L
L
---
LGL
WG
ML
A
T
A
A
PT
G
WWT
W
I
A
RT
L
PD
N
AE
A
GG
G
LMV
AVIQ
L
S
I
A
L
G
S
TA
GG
I
V
F
DR
LG
W
Q
S
T
F
-
---
-
A
M
SS
VLL
L
C
AG
V
L
T
F
V
T
ARQ
K
fig|478008.5.peg.3730
Escherichia coli O157:H7 str. EC869 (20-393/397)
I
F
A
M
T
L
CV
F
V
L
IA
S
EF
M
P
V
S
LL
TP
IA
RD
L
G
V
T
EGL
AG
R
G
I
A
I
SG
A
LA
V
L
T
SL
TLS
T
LA
G
KMN
R
K
FL
L
L
G
M
T
V
L
M
AV
S
G
LI
I
A
L
A
T
SY
LM
Y
M
V
G
R
A
MIG
V
A
I
G
G
F
WS
M
S
A
A
T
A
IR
L
V
P
Q
H
Q
V
T
R
A
L
A
I
F
NA
G
N
A
LA
T
V
V
AA
PLG
S
Y
LG
A
T
V
GWR
GA
FL
C
L
V
PMA
V
V
A
F
I
WQ
CIS
LP
SMDA
NK
S
H
T
SCG
AVFRL
F
S
R
RM
VV
VG
M
I
A
CG
L
F
FM
G
Q
F
A
L
FT
Y
V
R
P
F
L
E
S
V
T
R
V
N
SL
G
L
S
L
ILL
I
IG
V
A
GF
IG
T
L
V
V
SIF
LN
R
K
FYPTLM
A
IPG
L
M
A
V
I
AI
G
L
M
L
--
-
T
G
HH
V
WMVS
L
L
---
LGL
WG
ML
A
T
A
A
PT
G
WWT
W
I
A
RT
L
PD
N
AE
A
GG
G
LMV
AVIQ
L
S
I
A
L
G
S
TA
GG
I
V
F
DR
LG
W
Q
S
T
F
-
---
-
A
M
SS
VLL
L
C
AG
V
L
T
F
V
T
ARQ
K
fig|637388.3.peg.679
Escherichia coli O157:H7 str. FRIK2000 (20-393/397)
I
F
A
M
T
L
CV
F
V
L
IA
S
EF
M
P
V
S
LL
TP
IA
RD
L
G
V
T
EGL
AG
R
G
I
A
I
SG
A
LA
V
L
T
SL
TLS
T
LA
G
KMN
R
K
FL
L
L
G
M
T
V
L
M
AV
S
G
LI
I
A
L
A
T
SY
LM
Y
M
V
G
R
A
MIG
V
A
I
G
G
F
WS
M
S
A
A
T
A
IR
L
V
P
Q
H
Q
V
T
R
A
L
A
I
F
NA
G
N
A
LA
T
V
V
AA
PLG
S
Y
LG
A
T
V
GWR
GA
FL
C
L
V
PMA
V
V
A
F
I
WQ
CIS
LP
SMDA
NK
S
H
T
SCG
AVFRL
F
S
R
RM
VV
VG
M
I
A
CG
L
F
FM
G
Q
F
A
L
FT
Y
V
R
P
F
L
E
S
V
T
R
V
N
SL
G
L
S
L
ILL
I
IG
V
A
GF
IG
T
L
V
V
SIF
LN
R
K
FYPTLM
A
IPG
L
M
A
V
I
AI
G
L
M
L
--
-
T
G
HH
V
WMVS
L
L
---
LGL
WG
ML
A
T
A
A
PT
G
WWT
W
I
A
RT
L
PD
N
AE
A
GG
G
LMV
AVIQ
L
S
I
A
L
G
S
TA
GG
I
V
F
DR
LG
W
Q
S
T
F
-
---
-
A
M
SS
VLL
L
C
AG
V
L
T
F
V
T
ARQ
K
fig|570506.3.peg.1804
Escherichia coli O157:H7 str. FRIK966 (20-393/397)
I
F
A
M
T
L
CV
F
V
L
IA
S
EF
M
P
V
S
LL
TP
IA
RD
L
G
V
T
EGL
AG
R
G
I
A
I
SG
A
LA
V
L
T
SL
TLS
T
LA
G
KMN
R
K
FL
L
L
G
M
T
V
L
M
AV
S
G
LI
I
A
L
A
T
SY
LM
Y
M
V
G
R
A
MIG
V
A
I
G
G
F
WS
M
S
A
A
T
A
IR
L
V
P
Q
H
Q
V
T
R
A
L
A
I
F
NA
G
N
A
LA
T
V
V
AA
PLG
S
Y
LG
A
T
V
GWR
GA
FL
C
L
V
PMA
V
V
A
F
I
WQ
CIS
LP
SMDA
NK
S
H
T
SCG
AVFRL
F
S
R
RM
VV
VG
M
I
A
CG
L
F
FM
G
Q
F
A
L
FT
Y
V
R
P
F
L
E
S
V
T
R
V
N
SL
G
L
S
L
ILL
I
IG
V
A
GF
IG
T
L
V
V
SIF
LN
R
K
FYPTLM
A
IPG
L
M
A
V
I
AI
G
L
M
L
--
-
T
G
HH
V
WMVS
L
L
---
LGL
WG
ML
A
T
A
A
PT
G
WWT
W
I
A
RT
L
PD
N
AE
A
GG
G
LMV
AVIQ
L
S
I
A
L
G
S
TA
GG
I
V
F
DR
LG
W
Q
S
T
F
-
---
-
A
M
SS
VLL
L
C
AG
V
L
T
F
V
T
ARQ
K
fig|544404.4.peg.317
Escherichia coli O157:H7 str. TW14359 (20-393/397)
I
F
A
M
T
L
CV
F
V
L
IA
S
EF
M
P
V
S
LL
TP
IA
RD
L
G
V
T
EGL
AG
R
G
I
A
I
SG
A
LA
V
L
T
SL
TLS
T
LA
G
KMN
R
K
FL
L
L
G
M
T
V
L
M
AV
S
G
LI
I
A
L
A
T
SY
LM
Y
M
V
G
R
A
MIG
V
A
I
G
G
F
WS
M
S
A
A
T
A
IR
L
V
P
Q
H
Q
V
T
R
A
L
A
I
F
NA
G
N
A
LA
T
V
V
AA
PLG
S
Y
LG
A
T
V
GWR
GA
FL
C
L
V
PMA
V
V
A
F
I
WQ
CIS
LP
SMDA
NK
S
H
T
SCG
AVFRL
F
S
R
RM
VV
VG
M
I
A
CG
L
F
FM
G
Q
F
A
L
FT
Y
V
R
P
F
L
E
S
V
T
R
V
N
SL
G
L
S
L
ILL
I
IG
V
A
GF
IG
T
L
V
V
SIF
LN
R
K
FYPTLM
A
IPG
L
M
A
V
I
AI
G
L
M
L
--
-
T
G
HH
V
WMVS
L
L
---
LGL
WG
ML
A
T
A
A
PT
G
WWT
W
I
A
RT
L
PD
N
AE
A
GG
G
LMV
AVIQ
L
S
I
A
L
G
S
TA
GG
I
V
F
DR
LG
W
Q
S
T
F
-
---
-
A
M
SS
VLL
L
C
AG
V
L
T
F
V
T
ARQ
K
fig|550676.3.peg.1059
Escherichia coli B185 (1-371/375)
M
T
L
CV
F
V
L
IA
S
EF
M
P
V
S
LL
TP
I
T
RD
L
G
V
T
EGL
AG
Q
G
I
A
I
SG
A
LA
V
L
T
SL
TLS
T
LA
G
KMN
R
K
FL
L
L
G
M
T
V
L
M
AV
S
G
LI
I
A
L
A
S
N
Y
LM
Y
M
V
G
R
A
MIG
V
A
I
G
G
F
WS
M
S
A
A
T
A
IR
L
V
P
Q
H
Q
V
T
R
A
L
A
I
F
NA
G
N
A
LA
T
V
V
AA
PLG
S
Y
LG
A
T
V
GWR
GA
FL
C
L
V
PIA
V
V
A
F
I
WQ
CIS
LP
SMDA
NK
S
H
A
SFG
AVFRL
F
S
R
RM
VV
VG
M
I
A
CG
L
F
FM
G
Q
F
A
L
FT
Y
V
R
P
F
L
E
S
V
T
R
V
N
SL
G
L
S
L
ILL
I
IG
V
A
GF
IG
T
L
V
V
STF
LN
R
K
FYPTLM
A
IPG
L
M
A
V
I
AI
G
L
M
L
--
-
T
G
HH
V
WTVS
L
L
---
LGL
WG
ML
A
T
A
A
PT
G
WWT
W
I
A
RT
L
PD
N
AE
A
GG
G
LMV
AVIQ
L
S
I
A
L
G
S
TA
GG
I
V
F
DR
LG
W
Q
S
T
F
-
---
-
A
M
SS
VLL
L
C
AG
V
L
T
F
V
T
ARQ
K
fig|656444.3.peg.725
Escherichia coli TA280 (20-393/397)
I
F
A
M
T
L
CM
F
V
L
IA
S
EF
M
P
V
S
LL
TP
I
T
RD
L
G
V
T
EGL
AG
Q
G
I
A
I
SG
A
LA
V
L
T
SL
TLS
T
LA
G
KMN
R
K
FL
L
L
G
M
T
V
L
M
AV
S
G
LI
I
A
L
A
S
SY
LM
Y
M
V
G
R
A
MIG
V
A
I
G
G
F
WS
M
S
A
A
T
A
IR
L
V
P
Q
Q
Q
V
T
R
A
L
A
I
F
NA
G
N
A
LA
T
V
V
AA
PLG
S
Y
LG
A
T
V
GWR
GA
FL
C
L
V
PIA
V
V
A
F
I
WQ
CIS
LP
SMDA
NK
S
H
T
SFG
AVFRL
F
S
R
RM
VV
VG
M
I
A
CG
L
F
FM
G
Q
F
A
L
FT
Y
V
R
P
F
L
E
S
V
T
R
V
N
SL
G
L
S
L
ILL
I
IG
V
A
GF
IG
T
L
V
V
SAF
LN
R
K
FYPTLM
A
IPG
L
M
A
V
I
AI
G
L
M
L
--
-
T
G
HH
V
WTVS
L
L
---
LGL
WG
ML
A
T
A
A
PT
G
WWT
W
I
A
RT
L
PD
N
AE
A
GG
G
LMV
AVIQ
L
A
I
A
L
G
S
TA
GG
I
V
F
DR
LG
W
Q
S
T
F
-
---
-
A
M
SS
VLL
L
C
AG
V
L
T
F
V
T
ARQ
K
fig|562.371.peg.1277
Escherichia coli 1044A (1-371/375)
M
T
L
CV
F
V
L
IA
S
EF
M
P
V
S
LL
TP
IA
RD
L
G
V
T
EGL
AG
R
G
I
A
I
SG
A
LA
V
L
T
SL
TLS
T
LA
G
KMN
R
K
FL
L
L
G
M
T
V
L
M
AV
S
G
LI
I
A
L
A
T
SY
LM
Y
M
V
G
R
A
MIG
V
A
I
G
G
F
WS
M
S
A
A
T
A
IR
L
V
P
Q
H
Q
V
T
R
A
L
A
I
F
NA
G
N
A
LA
T
V
V
AA
PLG
S
Y
LG
A
T
V
GWR
GA
FL
C
L
V
PMA
V
V
A
F
I
WQ
CIS
LP
SMDA
NK
S
H
T
SCG
AVFRL
F
S
R
RM
VV
VG
M
I
A
CG
L
F
FM
G
Q
F
A
L
FT
Y
V
R
P
F
L
E
S
V
T
R
V
N
SL
G
L
S
L
ILL
I
IG
V
A
GF
IG
T
L
V
V
SIF
LN
R
K
CYPTLM
A
IPG
L
M
A
V
I
AI
G
L
M
L
--
-
T
G
HH
V
WMVS
L
L
---
LGL
WG
ML
A
T
A
A
PT
G
WWT
W
I
A
RT
L
PD
N
AE
A
GG
G
LMV
AVIQ
L
S
I
A
L
G
S
TA
GG
I
V
F
DR
LG
W
Q
S
T
F
-
---
-
A
M
SS
VLL
L
C
AG
V
L
T
F
V
T
ARQ
K
fig|562.373.peg.361
Escherichia coli 1125A (1-371/375)
M
T
L
CV
F
V
L
IA
S
EF
M
P
V
S
LL
TP
IA
RD
L
G
V
T
EGL
AG
R
G
I
A
I
SG
A
LA
V
L
T
SL
TLS
T
LA
G
KMN
R
K
FL
L
L
G
M
T
V
L
M
AV
S
G
LI
I
A
L
A
T
SY
LM
Y
M
V
G
R
A
MIG
V
A
I
G
G
F
WS
M
S
A
A
T
A
IR
L
V
P
Q
H
Q
V
T
R
A
L
A
I
F
NA
G
N
A
LA
T
V
V
AA
PLG
S
Y
LG
A
T
V
GWR
GA
FL
C
L
V
PMA
V
V
A
F
I
WQ
CIS
LP
SMDA
NK
S
H
T
SCG
AVFRL
F
S
R
RM
VV
VG
M
I
A
CG
L
F
FM
G
Q
F
A
L
FT
Y
V
R
P
F
L
E
S
V
T
R
V
N
SL
G
L
S
L
ILL
I
IG
V
A
GF
IG
T
L
V
V
SIF
LN
R
K
FYPTLM
A
IPG
L
M
A
V
I
AI
G
L
M
L
--
-
T
G
HH
V
WMVS
L
L
---
LGL
WG
ML
A
T
A
A
PT
G
WWT
W
I
A
RT
L
PD
N
AE
A
GG
G
LMV
AVIQ
L
S
I
A
L
G
S
TA
GG
I
V
F
DR
LG
W
Q
S
T
F
-
---
-
A
M
SS
VLL
L
C
AG
V
L
T
F
V
T
ARQ
K
fig|562.372.peg.732
Escherichia coli 1212A (1-371/375)
M
T
L
CV
F
V
L
IA
S
EF
M
P
V
S
LL
TP
IA
RD
L
G
V
T
EGL
AG
R
G
I
A
I
SG
A
LA
V
L
T
SL
TLS
T
LA
G
KMN
R
K
FL
L
L
G
M
T
V
L
M
AV
S
G
LI
I
A
L
A
T
SY
LM
Y
M
V
G
R
A
MIG
V
A
I
G
G
F
WS
M
S
A
A
T
A
IR
L
V
P
Q
H
Q
V
T
R
A
L
A
I
F
NA
G
N
A
LA
T
V
V
AA
PLG
S
Y
LG
A
T
V
GWR
GA
FL
C
L
V
PMA
V
V
A
F
I
WQ
CIS
LP
SMDA
NK
S
H
T
SCG
AVFRL
F
S
R
RM
VV
VG
M
I
A
CG
L
F
FM
G
Q
F
A
L
FT
Y
V
R
P
F
L
E
S
V
T
R
V
N
SL
G
L
S
L
ILL
I
IG
V
A
GF
IG
T
L
V
V
SIF
LN
R
K
FYPTLM
A
IPG
L
M
A
V
I
AI
G
L
M
L
--
-
T
G
HH
V
WMVS
L
L
---
LGL
WG
ML
A
T
A
A
PT
G
WWT
W
I
A
RT
L
PD
N
AE
A
GG
G
LMV
AVIQ
L
S
I
A
L
G
S
TA
GG
I
V
F
DR
LG
W
Q
S
T
F
-
---
-
A
M
SS
VLL
L
C
AG
V
L
T
F
V
T
ARQ
K
fig|444447.5.peg.3161
Escherichia coli O157:H7 str. EC4206 (1-371/375)
M
T
L
CV
F
V
L
IA
S
EF
M
P
V
S
LL
TP
IA
RD
L
G
V
T
EGL
AG
R
G
I
A
I
SG
A
LA
V
L
T
SL
TLS
T
LA
G
KMN
R
K
FL
L
L
G
M
T
V
L
M
AV
S
G
LI
I
A
L
A
T
SY
LM
Y
M
V
G
R
A
MIG
V
A
I
G
G
F
WS
M
S
A
A
T
A
IR
L
V
P
Q
H
Q
V
T
R
A
L
A
I
F
NA
G
N
A
LA
T
V
V
AA
PLG
S
Y
LG
A
T
V
GWR
GA
FL
C
L
V
PMA
V
V
A
F
I
WQ
CIS
LP
SMDA
NK
S
H
T
SCG
AVFRL
F
S
R
RM
VV
VG
M
I
A
CG
L
F
FM
G
Q
F
A
L
FT
Y
V
R
P
F
L
E
S
V
T
R
V
N
SL
G
L
S
L
ILL
I
IG
V
A
GF
IG
T
L
V
V
SIF
LN
R
K
FYPTLM
A
IPG
L
M
A
V
I
AI
G
L
M
L
--
-
T
G
HH
V
WMVS
L
L
---
LGL
WG
ML
A
T
A
A
PT
G
WWT
W
I
A
RT
L
PD
N
AE
A
GG
G
LMV
AVIQ
L
S
I
A
L
G
S
TA
GG
I
V
F
DR
LG
W
Q
S
T
F
-
---
-
A
M
SS
VLL
L
C
AG
V
L
T
F
V
T
ARQ
K
fig|478004.5.peg.2589
Escherichia coli O157:H7 str. EC4401 (1-371/375)
M
T
L
CV
F
V
L
IA
S
EF
M
P
V
S
LL
TP
IA
RD
L
G
V
T
EGL
AG
R
G
I
A
I
SG
A
LA
V
L
T
SL
TLS
T
LA
G
KMN
R
K
FL
L
L
G
M
T
V
L
M
AV
S
G
LI
I
A
L
A
T
SY
LM
Y
M
V
G
R
A
MIG
V
A
I
G
G
F
WS
M
S
A
A
T
A
IR
L
V
P
Q
H
Q
V
T
R
A
L
A
I
F
NA
G
N
A
LA
T
V
V
AA
PLG
S
Y
LG
A
T
V
GWR
GA
FL
C
L
V
PMA
V
V
A
F
I
WQ
CIS
LP
SMDA
NK
S
H
T
SCG
AVFRL
F
S
R
RM
VV
VG
M
I
A
CG
L
F
FM
G
Q
F
A
L
FT
Y
V
R
P
F
L
E
S
V
T
R
V
N
SL
G
L
S
L
ILL
I
IG
V
A
GF
IG
T
L
V
V
SIF
LN
R
K
FYPTLM
A
IPG
L
M
A
V
I
AI
G
L
M
L
--
-
T
G
HH
V
WMVS
L
L
---
LGL
WG
ML
A
T
A
A
PT
G
WWT
W
I
A
RT
L
PD
N
AE
A
GG
G
LMV
AVIQ
L
S
I
A
L
G
S
TA
GG
I
V
F
DR
LG
W
Q
S
T
F
-
---
-
A
M
SS
VLL
L
C
AG
V
L
T
F
V
T
ARQ
K
fig|478005.5.peg.3521
Escherichia coli O157:H7 str. EC4486 (1-371/375)
M
T
L
CV
F
V
L
IA
S
EF
M
P
V
S
LL
TP
IA
RD
L
G
V
T
EGL
AG
R
G
I
A
I
SG
A
LA
V
L
T
SL
TLS
T
LA
G
KMN
R
K
FL
L
L
G
M
T
V
L
M
AV
S
G
LI
I
A
L
A
T
SY
LM
Y
M
V
G
R
A
MIG
V
A
I
G
G
F
WS
M
S
A
A
T
A
IR
L
V
P
Q
H
Q
V
T
R
A
L
A
I
F
NA
G
N
A
LA
T
V
V
AA
PLG
S
Y
LG
A
T
V
GWR
GA
FL
C
L
V
PMA
V
V
A
F
I
WQ
CIS
LP
SMDA
NK
S
H
T
SCG
AVFRL
F
S
R
RM
VV
VG
M
I
A
CG
L
F
FM
G
Q
F
A
L
FT
Y
V
R
P
F
L
E
S
V
T
R
V
N
SL
G
L
S
L
ILL
I
IG
V
A
GF
IG
T
L
V
V
SIF
LN
R
K
FYPTLM
A
IPG
L
M
A
V
I
AI
G
L
M
L
--
-
T
G
HH
V
WMVS
L
L
---
LGL
WG
ML
A
T
A
A
PT
G
WWT
W
I
A
RT
L
PD
N
AE
A
GG
G
LMV
AVIQ
L
S
I
A
L
G
S
TA
GG
I
V
F
DR
LG
W
Q
S
T
F
-
---
-
A
M
SS
VLL
L
C
AG
V
L
T
F
V
T
ARQ
K
fig|550677.3.peg.704
Escherichia coli B354 (1-371/375)
M
T
L
CV
F
V
L
IA
S
EF
M
P
V
S
LL
TP
I
T
RD
L
G
V
T
EGL
AG
Q
G
I
A
I
SC
A
LA
V
L
T
SL
TLS
T
LA
G
KMN
R
K
FL
L
L
G
M
T
V
L
M
AV
S
G
LI
I
A
L
A
S
SY
LM
Y
M
V
G
R
A
MIG
V
A
I
G
G
F
WS
M
S
A
A
T
A
IR
L
V
P
Q
H
Q
V
T
R
A
L
A
I
F
NA
G
N
A
LA
T
V
V
AA
PLG
S
Y
LG
A
T
V
GWR
GA
FL
C
L
V
PIA
V
V
A
F
I
WQ
CIS
LP
SMDA
NK
S
H
T
SPG
DVFRL
F
S
R
RV
IA
VG
M
I
A
CG
L
F
FM
G
Q
F
A
L
FT
Y
V
R
P
F
L
E
S
V
T
R
V
N
SL
G
L
S
L
ILL
I
IG
V
A
GF
IG
T
L
V
V
SAF
LN
R
K
FYPTLM
A
IPG
L
M
A
V
I
AI
G
L
M
L
--
-
T
G
HH
V
WTVS
L
L
---
LGL
WG
ML
A
T
A
A
PT
G
WWT
W
I
A
RT
L
PD
N
AE
A
GG
G
LMV
AVIQ
L
A
I
A
L
G
S
TA
GG
I
V
F
DR
LG
W
Q
S
T
F
-
---
-
A
M
SS
VLL
L
C
AG
V
L
T
F
V
T
ARQ
K
Consen1
Primary consensus
MKINYPilaLAlgaFg
gttEF
pmGlL
iA
v
vsipaaG
mis
YA
gV
vgap
L
S
rr
LifL
alf
gnvls
ls
sy
L
isRi
f
HgaFfglga
va
v
p
gK
a
Ava
m
G
tlAnvlGvPlgt
lgq
fgWRmtFlaia
vi
m
sl
lP
ea
g
l
-
k
lrrPa
si
l
Tv
g
a
ft
ysYi
P
lq
Itg
s
f
TaillLiG
g
iGn
l
Gkl
ry
t
fllvl
lml
--
f
a
e
i
---
wgaa
fav
plQm
vl
A
a
l
a
gaFNlG
a
GA
Gg
v
s
-
lgl
ys
v
gAi
fAal
-
sllvf
r
qpEtVCVANS
Consen2
Secondary consensus
v
at
i
nma
iv
v
l
f
qtaqv
llt
v
lmsl
lk
lc
v
c
shamf
ia
df
lg
l
l
ai
ws
ts
ll
k
h
t
ls
i
av
m
g
aar
vse
is
ys
fltg
a
l
cv
v
gh
p
v
r
fms
q
la
a
m
v
g
ya
ft
v
m
h
t
a
f
m
a
l
s
i
r
qs
a
liilc
il
-
ipp
g
k
ccig
mi
gm
lm
g
v
s
ii
i
g
n
m
t
ahw
mn
i
a
-
gm
wlii
y
s
tl
a
Consensus 1
(when a gap)
Conservative difference
Consensus 2
(when a gap)
Nonconservative diff.
Other character