fig|1040638.4.peg.371
Escherichia coli O104:H4 str. LB226692
MSLFRR
G
EIWYASY
S
LP
G
GKR
I
KESLGTKDKRQA
Q
ELHDK
R
KAE
L
W
R
V
D
R
LG
-
----
-
D
M
P
-
-
-
--
--
--
----
DVT
F
EEA
CL
RWL
E
EK
A-
-
-D
K
K
S
I
D
S
DKSRI
A
FW
I
E
HF
E
G
IR
I
KD
I
S
E
AM
I
Y
S
V
I
S
K
A
Y
NR
KTK
E
R
WKL
QV
E
A
ALR
KGK
EP
P
AYIPKSV-
---
S
TQ
TKA
T
HLA
M
I
K
AILRAAE
R
D
W
K
W
L
EK
AP
VI
KI
PAV
K
NK
R
V-
-
RWL
EKE
EA
R
RLID
A
C
-
S
D
P
L
KSVV
KF
ALATGLR
R
SNI
I
NL
E
WQQIDMQ
R
RV
AW
V
NPE
D
SK
-
--
--
-
---
-
-
-
SNRAIGVALNDTAC
K
VLR
D
Q
I--
---
-
-
-
-
-
-
-
-
-
------
GKH
H
R
WVFV
Y
TTAARR--
-
--P
D
GTMT
P
S
I
R
K
MR
L
D
YN
T
S
W
L
T
A
C
RRAGI
E
N
FR
F
HDLRHTWASWLI
Q
S
GVPLSVLQ
E
MGGWESIEMV
-
R
RYA
H
LA
P
NHL
T
EH
A
R
K
ID
DI
L
GDD
VP
N
L
SH
P
E
V
F
ED
A
KKA
fig|340185.3.peg.2478
Escherichia coli E22
MSLFRRNEIWYASY
S
LP
G
GKR
I
KESLGTKDKRQA
Q
ELHDK
R
KAE
L
W
R
V
E
KLG
-
----
-
D
L
P
-
-
-
--
--
--
----
DVT
F
EEA
CL
RWL
E
EK
A-
-
-D
K
K
SLD
S
DKSRI
E
FWL
E
HF
E
G
IR
L
KD
I
S
E
AK
I
Y
SAV
S
R
M
H
NR
KTK
E
I
WK
Q
KV
QA
AIR
KGK
EP
P
VYEPKPV-
---
S
TQ
TKA
K
HLA
M
I
K
AILRAAE
R
D
W
K
W
L
EK
AP
VI
KI
PAV
R
NK
R
V-
-
RWL
EKE
EA
K
RLIDEC
-
P
EP
L
KSVV
KF
ALATGLR
K
SNI
I
NL
E
WQQIDMQ
R
RV
AW
V
NPE
E
SK
-
--
--
-
---
-
-
-
SNRAIGVALNDTAC
K
VLR
D
Q
I--
---
-
-
-
-
-
-
-
-
-
------
GKH
HKWVFVH
TKAAKR--
-
--A
D
GTST
PAVR
K
MR
I
D
SK
T
S
W
L
SA
C
RRAGI
E
DFR
F
HDLRHTWASWLI
Q
S
GVPLSVLQ
E
MGGWESIEMV
-
R
RYA
H
LA
P
NHL
T
EH
A
R
K
ID
DI
F
GDN
VP
N
MSH
C
G
IMEDIKKA
fig|340185.4.peg.2617
Escherichia coli E22
MSLFRRNEIWYASY
S
LP
G
GKR
I
KESLGTKDKRQA
Q
ELHDK
R
KAE
L
W
R
V
E
KLG
-
----
-
D
L
P
-
-
-
--
--
--
----
DVT
F
EEA
CL
RWL
E
EK
A-
-
-D
K
K
SLD
S
DKSRI
E
FWL
E
HF
E
G
IR
L
KD
I
S
E
AK
I
Y
SAV
S
R
M
H
NR
KTK
E
I
WK
Q
KV
QA
AIR
KGK
EP
P
VYEPKPV-
---
S
TQ
TKA
K
HLA
M
I
K
AILRAAE
R
D
W
K
W
L
EK
AP
VI
KI
PAV
R
NK
R
V-
-
RWL
EKE
EA
K
RLIDEC
-
P
EP
L
KSVV
KF
ALATGLR
K
SNI
I
NL
E
WQQIDMQ
R
RV
AW
V
NPE
E
SK
-
--
--
-
---
-
-
-
SNRAIGVALNDTAC
K
VLR
D
Q
I--
---
-
-
-
-
-
-
-
-
-
------
GKH
HKWVFVH
TKAAKR--
-
--A
D
GTST
PAVR
K
MR
I
D
SK
T
S
W
L
SA
C
RRAGI
E
DFR
F
HDLRHTWASWLI
Q
S
GVPLSVLQ
E
MGGWESIEMV
-
R
RYA
H
LA
P
NHL
T
EH
A
R
K
ID
DI
F
GDN
VP
N
MSH
C
G
IMEDIKKA
fig|562.375.peg.3943
Escherichia coli EC4100B
MSLFRRNEIWYASY
S
LP
G
GKR
I
KESLGTKDKRQA
Q
ELHDK
R
KAE
L
W
R
V
E
KLG
-
----
-
D
L
P
-
-
-
--
--
--
----
DVT
F
EEA
CL
RWL
E
EK
A-
-
-D
K
K
SLD
S
DKSRI
E
FWL
E
HF
E
G
IR
L
KD
I
S
E
AK
I
Y
SAV
S
R
M
H
NR
KTK
E
I
WK
Q
KV
QA
AIR
KGK
EP
P
VYEPKPV-
---
S
TQ
TKA
K
HLA
M
I
K
AILRAAE
R
D
W
K
W
L
EK
AP
VI
KI
PAV
R
NK
R
V-
-
RWL
EKE
EA
K
RLIDEC
-
P
EP
L
KSVV
KF
ALATGLR
K
SNI
I
NL
E
WQQIDMQ
R
RV
AW
V
NPE
E
SK
-
--
--
-
---
-
-
-
SNRAIGVALNDTAC
K
VLR
D
Q
I--
---
-
-
-
-
-
-
-
-
-
------
GKH
HKWVFVH
TKAAKR--
-
--A
D
GTST
PAVR
K
MR
I
D
SK
T
S
W
L
SA
C
RRAGI
E
DFR
F
HDLRHTWASWLI
Q
S
GVPLSVLQ
E
MGGWESIEMV
-
R
RYA
H
LA
P
NHL
T
EH
A
R
K
ID
DI
F
GDN
VP
N
MSH
C
G
IMEDIKKA
fig|714962.3.peg.529
Escherichia coli IHE3034
MSLFRRNEIWYASY
S
LP
G
GKR
I
KESLGTKDKRQA
Q
ELHDK
R
KAE
L
W
R
V
E
KLG
-
----
-
D
L
P
-
-
-
--
--
--
----
DVT
F
EEA
CL
RWL
E
EK
A-
-
-D
K
K
SLD
S
DKSRI
E
FWL
E
HF
E
G
IR
L
KD
I
S
E
AK
I
Y
SAV
S
R
M
H
NR
KTK
E
I
WK
Q
KV
QA
AIR
KGK
EP
P
VYEPKPV-
---
S
TQ
TKA
K
HLA
M
I
K
AILRAAE
R
D
W
K
W
L
EK
AP
VI
KI
PAV
R
NK
R
V-
-
RWL
EKE
EA
K
RLIDEC
-
P
EP
L
KSVV
KF
ALATGLR
K
SNI
I
NL
E
WQQIDMQ
R
RV
AW
V
NPE
E
SK
-
--
--
-
---
-
-
-
SNRAIGVALNDTAC
K
VLR
D
Q
I--
---
-
-
-
-
-
-
-
-
-
------
GKH
HKWVFVH
TKAAKR--
-
--A
D
GTST
PAVR
K
MR
I
D
SK
T
S
W
L
SA
C
RRAGI
E
DFR
F
HDLRHTWASWLI
Q
S
GVPLSVLQ
E
MGGWESIEMV
-
R
RYA
H
LA
P
NHL
T
EH
A
R
K
ID
DI
F
GDN
VP
N
MSH
C
G
IMEDIKKA
fig|749545.3.peg.3678
Escherichia coli MS 182-1
MSLFRRNEIWYASY
S
LP
G
GKR
I
KESLGTKDKRQA
Q
ELHDK
R
KAE
L
W
R
V
E
KLG
-
----
-
D
L
P
-
-
-
--
--
--
----
DVT
F
EEA
CL
RWL
E
EK
A-
-
-D
K
K
SLD
S
DKSRI
E
FWL
E
HF
E
G
IR
L
KD
I
S
E
AK
I
Y
SAV
S
R
M
H
NR
KTK
E
I
WK
Q
KV
QA
AIR
KGK
EP
P
VYEPKPV-
---
S
TQ
TKA
K
HLA
M
I
K
AILRAAE
R
D
W
K
W
L
EK
AP
VI
KI
PAV
R
NK
R
V-
-
RWL
EKE
EA
K
RLIDEC
-
P
EP
L
KSVV
KF
ALATGLR
K
SNI
I
NL
E
WQQIDMQ
R
RV
AW
V
NPE
E
SK
-
--
--
-
---
-
-
-
SNRAIGVALNDTAC
K
VLR
D
Q
I--
---
-
-
-
-
-
-
-
-
-
------
GKH
HKWVFVH
TKAAKR--
-
--A
D
GTST
PAVR
K
MR
I
D
SK
T
S
W
L
SA
C
RRAGI
E
DFR
F
HDLRHTWASWLI
Q
S
GVPLSVLQ
E
MGGWESIEMV
-
R
RYA
H
LA
P
NHL
T
EH
A
R
K
ID
DI
F
GDN
VP
N
MSH
C
G
IMEDIKKA
fig|749532.3.peg.2522
Escherichia coli MS 78-1
MSLFRRNEIWYASY
S
LP
G
GKR
I
KESLGTKDKRQA
Q
ELHDK
R
KAE
L
W
R
V
E
KLG
-
----
-
D
L
P
-
-
-
--
--
--
----
DVT
F
EEA
CL
RWL
E
EK
A-
-
-D
K
K
SLD
S
DKSRI
E
FWL
E
HF
E
G
IR
L
KD
I
S
E
AK
I
Y
SAV
S
R
M
H
NR
KTK
E
I
WK
Q
KV
QA
AIR
KGK
EP
P
VYEPKPV-
---
S
TQ
TKA
K
HLA
M
I
K
AILRAAE
R
D
W
K
W
L
EK
AP
VI
KI
PAV
R
NK
R
V-
-
RWL
EKE
EA
K
RLIDEC
-
P
EP
L
KSVV
KF
ALATGLR
K
SNI
I
NL
E
WQQIDMQ
R
RV
AW
V
NPE
E
SK
-
--
--
-
---
-
-
-
SNRAIGVALNDTAC
K
VLR
D
Q
I--
---
-
-
-
-
-
-
-
-
-
------
GKH
HKWVFVH
TKAAKR--
-
--A
D
GTST
PAVR
K
MR
I
D
SK
T
S
W
L
SA
C
RRAGI
E
DFR
F
HDLRHTWASWLI
Q
S
GVPLSVLQ
E
MGGWESIEMV
-
R
RYA
H
LA
P
NHL
T
EH
A
R
K
ID
DI
F
GDN
VP
N
MSH
C
G
IMEDIKKA
fig|585395.4.peg.537
Escherichia coli O103:H2 str. 12009
MSLFRRNEIWYASY
S
LP
G
GKR
I
KESLGTKDKRQA
Q
ELHDK
R
KAE
L
W
R
V
E
KLG
-
----
-
D
L
P
-
-
-
--
--
--
----
DVT
F
EEA
CL
RWL
E
EK
A-
-
-D
K
K
SLD
S
DKSRI
E
FWL
E
HF
E
G
IR
L
KD
I
S
E
AK
I
Y
SAV
S
R
M
H
NR
KTK
E
I
WK
Q
KV
QA
AIR
KGK
EP
P
VYEPKPV-
---
S
TQ
TKA
K
HLA
M
I
K
AILRAAE
R
D
W
K
W
L
EK
AP
VI
KI
PAV
R
NK
R
V-
-
RWL
EKE
EA
K
RLIDEC
-
P
EP
L
KSVV
KF
ALATGLR
K
SNI
I
NL
E
WQQIDMQ
R
RV
AW
V
NPE
E
SK
-
--
--
-
---
-
-
-
SNRAIGVALNDTAC
K
VLR
D
Q
I--
---
-
-
-
-
-
-
-
-
-
------
GKH
HKWVFVH
TKAAKR--
-
--A
D
GTST
PAVR
K
MR
I
D
SK
T
S
W
L
SA
C
RRAGI
E
DFR
F
HDLRHTWASWLI
Q
S
GVPLSVLQ
E
MGGWESIEMV
-
R
RYA
H
LA
P
NHL
T
EH
A
R
K
ID
DI
F
GDN
VP
N
MSH
C
G
IMEDIKKA
fig|585035.6.peg.531
Escherichia coli S88
MSLFRRNEIWYASY
S
LP
G
GKR
I
KESLGTKDKRQA
Q
ELHDK
R
KAE
L
W
R
V
E
KLG
-
----
-
D
L
P
-
-
-
--
--
--
----
DVT
F
EEA
CL
RWL
E
EK
A-
-
-D
K
K
SLD
S
DKSRI
E
FWL
E
HF
E
G
IR
L
KD
I
S
E
AK
I
Y
SAV
S
R
M
H
NR
KTK
E
I
WK
Q
KV
QA
AIR
KGK
EP
P
VYEPKPV-
---
S
TQ
TKA
K
HLA
M
I
K
AILRAAE
R
D
W
K
W
L
EK
AP
VI
KI
PAV
R
NK
R
V-
-
RWL
EKE
EA
K
RLIDEC
-
P
EP
L
KSVV
KF
ALATGLR
K
SNI
I
NL
E
WQQIDMQ
R
RV
AW
V
NPE
E
SK
-
--
--
-
---
-
-
-
SNRAIGVALNDTAC
K
VLR
D
Q
I--
---
-
-
-
-
-
-
-
-
-
------
GKH
HKWVFVH
TKAAKR--
-
--A
D
GTST
PAVR
K
MR
I
D
SK
T
S
W
L
SA
C
RRAGI
E
DFR
F
HDLRHTWASWLI
Q
S
GVPLSVLQ
E
MGGWESIEMV
-
R
RYA
H
LA
P
NHL
T
EH
A
R
K
ID
DI
F
GDN
VP
N
MSH
C
G
IMEDIKKA
fig|358709.5.peg.2015
Escherichia coli 101-1
MSLFRRNEIWYASY
S
LP
G
GKR
I
KESLGTKDKRQA
Q
ELHDK
R
KAE
L
W
R
V
E
KLG
-
----
-
D
L
P
-
-
-
--
--
--
----
DVT
F
EEA
CL
RWL
E
EK
A-
-
-D
K
K
SLD
S
DKSRI
E
FWL
E
HF
E
G
IR
L
KD
I
S
E
AK
I
Y
SAV
S
R
M
H
NR
KTK
E
I
WK
Q
KV
QA
AIR
KGK
EP
P
VYEPKPV-
---
S
TQ
TKA
K
HLA
M
I
K
AILRAAE
R
D
W
K
W
L
EK
AP
VI
KI
PAV
R
NK
R
V-
-
RWL
EKE
EA
K
RLIDEC
-
P
EP
L
KSVV
KF
ALATGLR
K
SNI
I
NL
E
WQQIDMQ
R
RV
AW
V
NPE
E
SK
-
--
--
-
---
-
-
-
SNRAIGVALNDTAC
K
VLR
D
Q
I--
---
-
-
-
-
-
-
-
-
-
------
GKH
HKWVFVH
TKAAKR--
-
--A
D
GTST
PAVR
K
MR
I
D
SK
T
S
W
L
SA
C
RRAGI
E
DFR
F
HDLRHTWASWLI
Q
S
GVPLSVLQ
E
MGGWESIEMV
-
R
RYA
H
LA
P
NHL
T
EH
A
R
K
ID
DI
F
GDN
VP
N
MSH
S
G
IMEDIKKA
fig|550672.3.peg.68
Escherichia coli B088
MSLFRRNEIWYASY
S
LP
G
GKR
I
KESLGTKDKRQA
Q
ELHDK
R
KAE
L
W
R
V
E
KLG
-
----
-
D
L
P
-
-
-
--
--
--
----
DVT
F
EEA
CL
RWL
E
EK
A-
-
-D
K
K
SLD
S
DKSRI
E
FWL
E
HF
E
G
IR
L
KD
I
S
E
AK
I
Y
SAV
S
R
M
H
NR
KTK
E
I
WK
Q
KV
QA
AIR
KGK
EP
P
VYEPKPV-
---
S
TQ
TKA
K
HLA
M
I
K
AILRAAE
R
D
W
K
W
L
EK
AP
VI
KI
PAV
R
NK
R
V-
-
RWL
EKE
EA
K
RLIDEC
-
P
EP
L
KSVV
KF
ALATGLR
K
SNI
I
NL
E
WQQIDMQ
R
RV
AW
V
NPE
E
SK
-
--
--
-
---
-
-
-
SNRAIGVALNDTAC
K
VLR
D
Q
I--
---
-
-
-
-
-
-
-
-
-
------
GKH
HKWVFVH
TKAAKR--
-
--A
D
GTST
PAVR
K
MR
I
D
SK
T
S
W
L
SA
C
RRAGI
E
DFR
F
HDLRHTWASWLI
Q
S
GVPLSVLQ
E
MGGWESIEMV
-
R
RYA
H
LA
P
NHL
T
EH
A
R
K
ID
DI
F
GDN
VP
N
MSH
S
G
IMEDIKKA
fig|573235.3.peg.579
Escherichia coli O26:H11 str. 11368
MSLFRRNEIWYASY
S
LP
G
GKR
I
KESLGTKDKRQA
Q
ELHDK
R
KAE
L
W
R
V
E
KLG
-
----
-
D
L
P
-
-
-
--
--
--
----
DVT
F
EEA
CL
RWL
E
EK
A-
-
-D
K
K
SLD
S
DKSRI
E
FWL
E
HF
E
G
IR
L
KD
I
S
E
AK
I
Y
SAV
S
R
M
H
NR
KTK
E
I
WK
Q
KV
QA
AIR
KGK
EP
P
VYEPKPV-
---
S
TQ
TKA
K
HLA
M
I
K
AILRAAE
R
D
W
K
W
L
EK
AP
VI
KI
PAV
R
NK
R
V-
-
RWL
EKE
EA
K
RLIDEC
-
P
EP
L
KSVV
KF
ALATGLR
K
SNI
I
NL
E
WQQIDMQ
R
RV
AW
V
NPE
E
SK
-
--
--
-
---
-
-
-
SNRAIGVALNDTAC
K
VLR
D
Q
I--
---
-
-
-
-
-
-
-
-
-
------
GKH
HKWVFVH
TKAAKR--
-
--A
D
GTST
PAVR
K
MR
I
D
SK
T
S
W
L
SA
C
RRAGI
E
DFR
F
HDLRHTWASWLI
Q
S
GVPLSVLQ
E
MGGWESIEMV
-
R
RYA
H
LA
P
NHL
T
EH
A
R
K
ID
DI
F
GDN
VP
N
MSH
S
G
IMEDIKKA
fig|701177.3.peg.657
Escherichia coli O55:H7 str. CB9615
MSLFRRNEIWYASY
S
LP
G
GKR
I
KESLGTKDKRQA
Q
ELHDK
R
KAE
L
W
R
V
E
KLG
-
----
-
D
L
P
-
-
-
--
--
--
----
DVT
F
EEA
CL
RWL
E
EK
A-
-
-D
K
K
SLD
S
DKSRI
E
FWL
E
HF
E
G
IR
L
KD
I
S
E
AK
I
Y
SAV
S
R
M
H
NR
KTK
E
I
WK
Q
KV
QA
AIR
KGK
EP
P
VYEPKPV-
---
S
TQ
TKA
K
HLA
M
I
K
AILRAAE
R
D
W
K
W
L
EK
AP
VI
KI
PAV
R
NK
R
V-
-
RWL
EKE
EA
K
RLIDEC
-
P
EP
L
KSVV
KF
ALATGLR
K
SNI
I
NL
E
WQQIDMQ
R
RV
AW
V
NPE
E
SK
-
--
--
-
---
-
-
-
SNRAIGVALNDTAC
K
VLR
D
Q
I--
---
-
-
-
-
-
-
-
-
-
------
GKH
HKWVFVH
TKAAKR--
-
--A
D
GTST
PAVR
K
MR
I
D
SK
T
S
W
L
SA
C
RRAGI
E
DFR
F
HDLRHTWASWLI
Q
S
GVPLSVLQ
E
MGGWESIEMV
-
R
RYA
H
LA
P
NHL
T
EH
A
R
K
ID
DI
F
GDN
VP
N
MSH
S
G
IMEDIKKA
fig|656393.3.peg.1192
Escherichia coli H299
MSLFRRNEIWYASY
S
LP
G
GKR
I
KESLGTKDKRQA
Q
ELHDK
R
KAE
L
W
R
A
E
KLG
-
----
-
D
L
P
-
-
-
--
--
--
----
DVT
F
EEA
CL
RWL
E
EK
A-
-
-D
K
K
SLD
S
DKSRI
E
FWL
E
HF
E
G
IR
L
KD
I
S
E
AK
I
Y
SAV
S
R
M
H
NR
KTK
E
I
WK
Q
KV
QA
AIR
KGK
EP
P
VYEPKPV-
---
S
TQ
TKA
K
HLA
M
I
K
AILRAAE
R
D
W
K
W
L
EK
AP
VI
KI
PAV
R
NK
R
V-
-
RWL
EKE
EA
K
RLIDEC
-
P
EP
L
KSVV
KF
ALATGLR
K
SNI
I
NL
E
WQQIDMQ
R
RV
AW
V
NPE
E
SK
-
--
--
-
---
-
-
-
SNRAIGVALNDTAC
K
VLR
D
Q
I--
---
-
-
-
-
-
-
-
-
-
------
GKH
HKWVFVH
TKAAKR--
-
--A
D
GTST
PAVR
K
MR
I
D
SK
T
S
W
L
SA
C
RRAGI
E
DFR
F
HDLRHTWASWLI
Q
S
GVPLSVLQ
E
MGGWESIEMV
-
R
RYA
H
LA
P
NHL
T
EH
A
R
K
ID
DI
F
GDN
VP
N
MSH
C
G
IMEDIKKA
fig|595496.3.peg.459
Escherichia coli BW2952
MSLFRRNEIWYASY
S
LP
G
GKR
I
KESLGTKDKRQA
Q
ELHDK
R
KAE
L
W
R
V
E
KLG
-
----
-
D
L
P
-
-
-
--
--
--
----
DVT
F
EEA
CL
RWL
E
EK
A-
-
-D
K
K
SLD
S
DKSRI
E
FWL
E
HF
E
G
IR
L
KD
I
S
E
AK
I
Y
SAV
S
R
M
H
NR
KTK
E
I
WK
Q
KV
QA
AIR
KGK
EL
P
VYEPKPV-
---
S
TQ
TKA
K
HLA
M
I
K
AILRAAE
R
D
W
K
W
L
EK
AP
VI
KI
PAV
R
NK
R
V-
-
RWL
EKE
EA
K
RLIDEC
-
P
EP
L
KSVV
KF
ALATGLR
K
SNI
I
NL
E
WQQIDMQ
R
RV
AW
V
NPE
E
SK
-
--
--
-
---
-
-
-
SNRAIGVALNDTAC
K
VLR
D
Q
I--
---
-
-
-
-
-
-
-
-
-
------
GKH
HKWVFVH
TKAAKR--
-
--A
D
GTST
PAVR
K
MR
I
D
SK
T
S
W
L
SA
C
RRAGI
E
DFR
F
HDLRHTWASWLI
Q
S
GVPLSVLQ
E
MGGWESIEMV
-
R
RYA
H
LA
P
NHL
T
EH
A
R
K
ID
DI
F
GDN
VP
N
MSH
S
EIMEDIKKA
fig|83333.1.peg.533
Escherichia coli K12
MSLFRRNEIWYASY
S
LP
G
GKR
I
KESLGTKDKRQA
Q
ELHDK
R
KAE
L
W
R
V
E
KLG
-
----
-
D
L
P
-
-
-
--
--
--
----
DVT
F
EEA
CL
RWL
E
EK
A-
-
-D
K
K
SLD
S
DKSRI
E
FWL
E
HF
E
G
IR
L
KD
I
S
E
AK
I
Y
SAV
S
R
M
H
NR
KTK
E
I
WK
Q
KV
QA
AIR
KGK
EL
P
VYEPKPV-
---
S
TQ
TKA
K
HLA
M
I
K
AILRAAE
R
D
W
K
W
L
EK
AP
VI
KI
PAV
R
NK
R
V-
-
RWL
EKE
EA
K
RLIDEC
-
P
EP
L
KSVV
KF
ALATGLR
K
SNI
I
NL
E
WQQIDMQ
R
RV
AW
V
NPE
E
SK
-
--
--
-
---
-
-
-
SNRAIGVALNDTAC
K
VLR
D
Q
I--
---
-
-
-
-
-
-
-
-
-
------
GKH
HKWVFVH
TKAAKR--
-
--A
D
GTST
PAVR
K
MR
I
D
SK
T
S
W
L
SA
C
RRAGI
E
DFR
F
HDLRHTWASWLI
Q
S
GVPLSVLQ
E
MGGWESIEMV
-
R
RYA
H
LA
P
NHL
T
EH
A
R
K
ID
DI
F
GDN
VP
N
MSH
S
EIMEDIKKA
fig|316407.3.peg.519
Escherichia coli W3110
MSLFRRNEIWYASY
S
LP
G
GKR
I
KESLGTKDKRQA
Q
ELHDK
R
KAE
L
W
R
V
E
KLG
-
----
-
D
L
P
-
-
-
--
--
--
----
DVT
F
EEA
CL
RWL
E
EK
A-
-
-D
K
K
SLD
S
DKSRI
E
FWL
E
HF
E
G
IR
L
KD
I
S
E
AK
I
Y
SAV
S
R
M
H
NR
KTK
E
I
WK
Q
KV
QA
AIR
KGK
EL
P
VYEPKPV-
---
S
TQ
TKA
K
HLA
M
I
K
AILRAAE
R
D
W
K
W
L
EK
AP
VI
KI
PAV
R
NK
R
V-
-
RWL
EKE
EA
K
RLIDEC
-
P
EP
L
KSVV
KF
ALATGLR
K
SNI
I
NL
E
WQQIDMQ
R
RV
AW
V
NPE
E
SK
-
--
--
-
---
-
-
-
SNRAIGVALNDTAC
K
VLR
D
Q
I--
---
-
-
-
-
-
-
-
-
-
------
GKH
HKWVFVH
TKAAKR--
-
--A
D
GTST
PAVR
K
MR
I
D
SK
T
S
W
L
SA
C
RRAGI
E
DFR
F
HDLRHTWASWLI
Q
S
GVPLSVLQ
E
MGGWESIEMV
-
R
RYA
H
LA
P
NHL
T
EH
A
R
K
ID
DI
F
GDN
VP
N
MSH
S
EIMEDIKKA
fig|316385.5.peg.490
Escherichia coli str. K-12 substr. DH10B
MSLFRRNEIWYASY
S
LP
G
GKR
I
KESLGTKDKRQA
Q
ELHDK
R
KAE
L
W
R
V
E
KLG
-
----
-
D
L
P
-
-
-
--
--
--
----
DVT
F
EEA
CL
RWL
E
EK
A-
-
-D
K
K
SLD
S
DKSRI
E
FWL
E
HF
E
G
IR
L
KD
I
S
E
AK
I
Y
SAV
S
R
M
H
NR
KTK
E
I
WK
Q
KV
QA
AIR
KGK
EL
P
VYEPKPV-
---
S
TQ
TKA
K
HLA
M
I
K
AILRAAE
R
D
W
K
W
L
EK
AP
VI
KI
PAV
R
NK
R
V-
-
RWL
EKE
EA
K
RLIDEC
-
P
EP
L
KSVV
KF
ALATGLR
K
SNI
I
NL
E
WQQIDMQ
R
RV
AW
V
NPE
E
SK
-
--
--
-
---
-
-
-
SNRAIGVALNDTAC
K
VLR
D
Q
I--
---
-
-
-
-
-
-
-
-
-
------
GKH
HKWVFVH
TKAAKR--
-
--A
D
GTST
PAVR
K
MR
I
D
SK
T
S
W
L
SA
C
RRAGI
E
DFR
F
HDLRHTWASWLI
Q
S
GVPLSVLQ
E
MGGWESIEMV
-
R
RYA
H
LA
P
NHL
T
EH
A
R
K
ID
DI
F
GDN
VP
N
MSH
S
EIMEDIKKA
fig|316385.7.peg.499
Escherichia coli str. K-12 substr. DH10B
MSLFRRNEIWYASY
S
LP
G
GKR
I
KESLGTKDKRQA
Q
ELHDK
R
KAE
L
W
R
V
E
KLG
-
----
-
D
L
P
-
-
-
--
--
--
----
DVT
F
EEA
CL
RWL
E
EK
A-
-
-D
K
K
SLD
S
DKSRI
E
FWL
E
HF
E
G
IR
L
KD
I
S
E
AK
I
Y
SAV
S
R
M
H
NR
KTK
E
I
WK
Q
KV
QA
AIR
KGK
EL
P
VYEPKPV-
---
S
TQ
TKA
K
HLA
M
I
K
AILRAAE
R
D
W
K
W
L
EK
AP
VI
KI
PAV
R
NK
R
V-
-
RWL
EKE
EA
K
RLIDEC
-
P
EP
L
KSVV
KF
ALATGLR
K
SNI
I
NL
E
WQQIDMQ
R
RV
AW
V
NPE
E
SK
-
--
--
-
---
-
-
-
SNRAIGVALNDTAC
K
VLR
D
Q
I--
---
-
-
-
-
-
-
-
-
-
------
GKH
HKWVFVH
TKAAKR--
-
--A
D
GTST
PAVR
K
MR
I
D
SK
T
S
W
L
SA
C
RRAGI
E
DFR
F
HDLRHTWASWLI
Q
S
GVPLSVLQ
E
MGGWESIEMV
-
R
RYA
H
LA
P
NHL
T
EH
A
R
K
ID
DI
F
GDN
VP
N
MSH
S
EIMEDIKKA
fig|511145.12.peg.558
Escherichia coli str. K-12 substr. MG1655
MSLFRRNEIWYASY
S
LP
G
GKR
I
KESLGTKDKRQA
Q
ELHDK
R
KAE
L
W
R
V
E
KLG
-
----
-
D
L
P
-
-
-
--
--
--
----
DVT
F
EEA
CL
RWL
E
EK
A-
-
-D
K
K
SLD
S
DKSRI
E
FWL
E
HF
E
G
IR
L
KD
I
S
E
AK
I
Y
SAV
S
R
M
H
NR
KTK
E
I
WK
Q
KV
QA
AIR
KGK
EL
P
VYEPKPV-
---
S
TQ
TKA
K
HLA
M
I
K
AILRAAE
R
D
W
K
W
L
EK
AP
VI
KI
PAV
R
NK
R
V-
-
RWL
EKE
EA
K
RLIDEC
-
P
EP
L
KSVV
KF
ALATGLR
K
SNI
I
NL
E
WQQIDMQ
R
RV
AW
V
NPE
E
SK
-
--
--
-
---
-
-
-
SNRAIGVALNDTAC
K
VLR
D
Q
I--
---
-
-
-
-
-
-
-
-
-
------
GKH
HKWVFVH
TKAAKR--
-
--A
D
GTST
PAVR
K
MR
I
D
SK
T
S
W
L
SA
C
RRAGI
E
DFR
F
HDLRHTWASWLI
Q
S
GVPLSVLQ
E
MGGWESIEMV
-
R
RYA
H
LA
P
NHL
T
EH
A
R
K
ID
DI
F
GDN
VP
N
MSH
S
EIMEDIKKA
fig|511145.6.peg.551
Escherichia coli str. K-12 substr. MG1655
MSLFRRNEIWYASY
S
LP
G
GKR
I
KESLGTKDKRQA
Q
ELHDK
R
KAE
L
W
R
V
E
KLG
-
----
-
D
L
P
-
-
-
--
--
--
----
DVT
F
EEA
CL
RWL
E
EK
A-
-
-D
K
K
SLD
S
DKSRI
E
FWL
E
HF
E
G
IR
L
KD
I
S
E
AK
I
Y
SAV
S
R
M
H
NR
KTK
E
I
WK
Q
KV
QA
AIR
KGK
EL
P
VYEPKPV-
---
S
TQ
TKA
K
HLA
M
I
K
AILRAAE
R
D
W
K
W
L
EK
AP
VI
KI
PAV
R
NK
R
V-
-
RWL
EKE
EA
K
RLIDEC
-
P
EP
L
KSVV
KF
ALATGLR
K
SNI
I
NL
E
WQQIDMQ
R
RV
AW
V
NPE
E
SK
-
--
--
-
---
-
-
-
SNRAIGVALNDTAC
K
VLR
D
Q
I--
---
-
-
-
-
-
-
-
-
-
------
GKH
HKWVFVH
TKAAKR--
-
--A
D
GTST
PAVR
K
MR
I
D
SK
T
S
W
L
SA
C
RRAGI
E
DFR
F
HDLRHTWASWLI
Q
S
GVPLSVLQ
E
MGGWESIEMV
-
R
RYA
H
LA
P
NHL
T
EH
A
R
K
ID
DI
F
GDN
VP
N
MSH
S
EIMEDIKKA
fig|340186.3.peg.807
Escherichia coli E110019
MSLFRRNEIWYASY
S
LP
G
GKR
I
KESLGTKDKRQA
Q
ELHDK
R
KAE
L
W
R
V
E
KLG
-
----
-
D
L
P
-
-
-
--
--
--
----
DVT
F
EEA
CL
RWL
E
EK
A-
-
-D
K
K
SLD
S
DKSRI
E
FWL
E
HF
E
G
IR
L
KD
I
S
E
AK
I
Y
SAV
S
R
M
H
NR
KTK
E
I
WK
Q
KV
QA
AIR
KGK
EL
P
VYEPKPV-
---
S
TQ
TKA
K
HLA
M
I
K
AILRAAE
R
D
W
K
W
L
EK
AP
VI
KI
PAV
R
NK
R
V-
-
RWL
EKE
EA
K
RLIDEC
-
P
EP
L
KSVV
KF
ALATGLR
K
SNI
I
NL
E
WQQIDMQ
R
RV
AW
V
NPE
E
SK
-
--
--
-
---
-
-
-
SNRAIGVALNDTAC
K
VLR
D
Q
I--
---
-
-
-
-
-
-
-
-
-
------
GKH
HKWVFVH
TKAAKR--
-
--A
D
GTST
PAVR
K
MR
I
D
SK
T
S
W
L
SA
C
RRAGI
E
DFR
F
HDLRHTWASWLI
Q
S
GVPLSVLQ
E
MGGWESIEMV
-
R
RYA
H
LA
P
NHL
T
EH
A
R
K
ID
DI
F
GDN
VP
N
MSH
S
G
IMEDIKKA
fig|340186.5.peg.840
Escherichia coli E110019
MSLFRRNEIWYASY
S
LP
G
GKR
I
KESLGTKDKRQA
Q
ELHDK
R
KAE
L
W
R
V
E
KLG
-
----
-
D
L
P
-
-
-
--
--
--
----
DVT
F
EEA
CL
RWL
E
EK
A-
-
-D
K
K
SLD
S
DKSRI
E
FWL
E
HF
E
G
IR
L
KD
I
S
E
AK
I
Y
SAV
S
R
M
H
NR
KTK
E
I
WK
Q
KV
QA
AIR
KGK
EL
P
VYEPKPV-
---
S
TQ
TKA
K
HLA
M
I
K
AILRAAE
R
D
W
K
W
L
EK
AP
VI
KI
PAV
R
NK
R
V-
-
RWL
EKE
EA
K
RLIDEC
-
P
EP
L
KSVV
KF
ALATGLR
K
SNI
I
NL
E
WQQIDMQ
R
RV
AW
V
NPE
E
SK
-
--
--
-
---
-
-
-
SNRAIGVALNDTAC
K
VLR
D
Q
I--
---
-
-
-
-
-
-
-
-
-
------
GKH
HKWVFVH
TKAAKR--
-
--A
D
GTST
PAVR
K
MR
I
D
SK
T
S
W
L
SA
C
RRAGI
E
DFR
F
HDLRHTWASWLI
Q
S
GVPLSVLQ
E
MGGWESIEMV
-
R
RYA
H
LA
P
NHL
T
EH
A
R
K
ID
DI
F
GDN
VP
N
MSH
S
G
IMEDIKKA
fig|656379.3.peg.1032
Escherichia coli FVEC1302
MSLFRRNEIWYASY
S
LP
G
GKR
I
KESLGTKDKRQA
Q
ELHDK
R
KAE
L
W
R
V
E
KLG
-
----
-
D
L
P
-
-
-
--
--
--
----
DVT
F
EEA
CL
RWL
E
EK
A-
-
-D
K
K
SLD
S
DKSRI
E
FWL
E
HF
E
G
IR
L
KD
I
S
E
AK
I
Y
SAV
S
R
M
H
NR
KTK
E
I
WK
Q
KV
QA
AIR
KGK
EL
P
VYEPKPV-
---
S
TQ
TKA
K
HLA
M
I
K
AILRAAE
R
D
W
K
W
L
EK
AP
VI
KI
PAV
R
NK
R
V-
-
RWL
EKE
EA
K
RLIDEC
-
P
EP
L
KSVV
KF
ALATGLR
K
SNI
I
NL
E
WQQIDMQ
R
RV
AW
V
NPE
E
SK
-
--
--
-
---
-
-
-
SNRAIGVALNDTAC
K
VLR
D
Q
I--
---
-
-
-
-
-
-
-
-
-
------
GKH
HKWVFVH
TKAAKR--
-
--A
D
GTST
PAVR
K
MR
I
D
SK
T
S
W
L
SA
C
RRAGI
E
DFR
F
HDLRHTWASWLI
Q
S
GVPLSVLQ
E
MGGWESIEMV
-
R
RYA
H
LA
P
NHL
T
EH
A
R
K
ID
DI
F
GDN
VP
N
MSH
S
G
IMEDIKKA
fig|656380.3.peg.790
Escherichia coli FVEC1412
MSLFRRNEIWYASY
S
LP
G
GKR
I
KESLGTKDKRQA
Q
ELHDK
R
KAE
L
W
R
V
E
KLG
-
----
-
D
L
P
-
-
-
--
--
--
----
DVT
F
EEA
CL
RWL
E
EK
A-
-
-D
K
K
SLD
S
DKSRI
E
FWL
E
HF
E
G
IR
L
KD
I
S
E
AK
I
Y
SAV
S
R
M
H
NR
KTK
E
I
WK
Q
KV
QA
AIR
KGK
EL
P
VYEPKPV-
---
S
TQ
TKA
K
HLA
M
I
K
AILRAAE
R
D
W
K
W
L
EK
AP
VI
KI
PAV
R
NK
R
V-
-
RWL
EKE
EA
K
RLIDEC
-
P
EP
L
KSVV
KF
ALATGLR
K
SNI
I
NL
E
WQQIDMQ
R
RV
AW
V
NPE
E
SK
-
--
--
-
---
-
-
-
SNRAIGVALNDTAC
K
VLR
D
Q
I--
---
-
-
-
-
-
-
-
-
-
------
GKH
HKWVFVH
TKAAKR--
-
--A
D
GTST
PAVR
K
MR
I
D
SK
T
S
W
L
SA
C
RRAGI
E
DFR
F
HDLRHTWASWLI
Q
S
GVPLSVLQ
E
MGGWESIEMV
-
R
RYA
H
LA
P
NHL
T
EH
A
R
K
ID
DI
F
GDN
VP
N
MSH
S
G
IMEDIKKA
fig|679205.4.peg.248
Escherichia coli MS 124-1
MSLFRRNEIWYASY
S
LP
G
GKR
I
KESLGTKDKRQA
Q
ELHDK
R
KAE
L
W
R
V
E
KLG
-
----
-
D
L
P
-
-
-
--
--
--
----
DVT
F
EEA
CL
RWL
E
EK
A-
-
-D
K
K
SLD
S
DKSRI
E
FWL
E
HF
E
G
IR
L
KD
I
S
E
AK
I
Y
SAV
S
R
M
H
NR
KTK
E
I
WK
Q
KV
QA
AIR
KGK
EL
P
VYEPKPV-
---
S
TQ
TKA
K
HLA
M
I
K
AILRAAE
R
D
W
K
W
L
EK
AP
VI
KI
PAV
R
NK
R
V-
-
RWL
EKE
EA
K
RLIDEC
-
P
EP
L
KSVV
KF
ALATGLR
K
SNI
I
NL
E
WQQIDMQ
R
RV
AW
V
NPE
E
SK
-
--
--
-
---
-
-
-
SNRAIGVALNDTAC
K
VLR
D
Q
I--
---
-
-
-
-
-
-
-
-
-
------
GKH
HKWVFVH
TKAAKR--
-
--A
D
GTST
PAVR
K
MR
I
D
SK
T
S
W
L
SA
C
RRAGI
E
DFR
F
HDLRHTWASWLI
Q
S
GVPLSVLQ
E
MGGWESIEMV
-
R
RYA
H
LA
P
NHL
T
EH
A
R
K
ID
DI
F
GDN
VP
N
MSH
S
G
IMEDIKKA
fig|749547.3.peg.1384
Escherichia coli MS 187-1
MSLFRRNEIWYASY
S
LP
G
GKR
I
KESLGTKDKRQA
Q
ELHDK
R
KAE
L
W
R
V
E
KLG
-
----
-
D
L
P
-
-
-
--
--
--
----
DVT
F
EEA
CL
RWL
E
EK
A-
-
-D
K
K
SLD
S
DKSRI
E
FWL
E
HF
E
G
IR
L
KD
I
S
E
AK
I
Y
SAV
S
R
M
H
NR
KTK
E
I
WK
Q
KV
QA
AIR
KGK
EL
P
VYEPKPV-
---
S
TQ
TKA
K
HLA
M
I
K
AILRAAE
R
D
W
K
W
L
EK
AP
VI
KI
PAV
R
NK
R
V-
-
RWL
EKE
EA
K
RLIDEC
-
P
EP
L
KSVV
KF
ALATGLR
K
SNI
I
NL
E
WQQIDMQ
R
RV
AW
V
NPE
E
SK
-
--
--
-
---
-
-
-
SNRAIGVALNDTAC
K
VLR
D
Q
I--
---
-
-
-
-
-
-
-
-
-
------
GKH
HKWVFVH
TKAAKR--
-
--A
D
GTST
PAVR
K
MR
I
D
SK
T
S
W
L
SA
C
RRAGI
E
DFR
F
HDLRHTWASWLI
Q
S
GVPLSVLQ
E
MGGWESIEMV
-
R
RYA
H
LA
P
NHL
T
EH
A
R
K
ID
DI
F
GDN
VP
N
MSH
S
G
IMEDIKKA
fig|749549.3.peg.1403
Escherichia coli MS 198-1
MSLFRRNEIWYASY
S
LP
G
GKR
I
KESLGTKDKRQA
Q
ELHDK
R
KAE
L
W
R
V
E
KLG
-
----
-
D
L
P
-
-
-
--
--
--
----
DVT
F
EEA
CL
RWL
E
EK
A-
-
-D
K
K
SLD
S
DKSRI
E
FWL
E
HF
E
G
IR
L
KD
I
S
E
AK
I
Y
SAV
S
R
M
H
NR
KTK
E
I
WK
Q
KV
QA
AIR
KGK
EL
P
VYEPKPV-
---
S
TQ
TKA
K
HLA
M
I
K
AILRAAE
R
D
W
K
W
L
EK
AP
VI
KI
PAV
R
NK
R
V-
-
RWL
EKE
EA
K
RLIDEC
-
P
EP
L
KSVV
KF
ALATGLR
K
SNI
I
NL
E
WQQIDMQ
R
RV
AW
V
NPE
E
SK
-
--
--
-
---
-
-
-
SNRAIGVALNDTAC
K
VLR
D
Q
I--
---
-
-
-
-
-
-
-
-
-
------
GKH
HKWVFVH
TKAAKR--
-
--A
D
GTST
PAVR
K
MR
I
D
SK
T
S
W
L
SA
C
RRAGI
E
DFR
F
HDLRHTWASWLI
Q
S
GVPLSVLQ
E
MGGWESIEMV
-
R
RYA
H
LA
P
NHL
T
EH
A
R
K
ID
DI
F
GDN
VP
N
MSH
S
G
IMEDIKKA
fig|749533.3.peg.1256
Escherichia coli MS 84-1
MSLFRRNEIWYASY
S
LP
G
GKR
I
KESLGTKDKRQA
Q
ELHDK
R
KAE
L
W
R
V
E
KLG
-
----
-
D
L
P
-
-
-
--
--
--
----
DVT
F
EEA
CL
RWL
E
EK
A-
-
-D
K
K
SLD
S
DKSRI
E
FWL
E
HF
E
G
IR
L
KD
I
S
E
AK
I
Y
SAV
S
R
M
H
NR
KTK
E
I
WK
Q
KV
QA
AIR
KGK
EL
P
VYEPKPV-
---
S
TQ
TKA
K
HLA
M
I
K
AILRAAE
R
D
W
K
W
L
EK
AP
VI
KI
PAV
R
NK
R
V-
-
RWL
EKE
EA
K
RLIDEC
-
P
EP
L
KSVV
KF
ALATGLR
K
SNI
I
NL
E
WQQIDMQ
R
RV
AW
V
NPE
E
SK
-
--
--
-
---
-
-
-
SNRAIGVALNDTAC
K
VLR
D
Q
I--
---
-
-
-
-
-
-
-
-
-
------
GKH
HKWVFVH
TKAAKR--
-
--A
D
GTST
PAVR
K
MR
I
D
SK
T
S
W
L
SA
C
RRAGI
E
DFR
F
HDLRHTWASWLI
Q
S
GVPLSVLQ
E
MGGWESIEMV
-
R
RYA
H
LA
P
NHL
T
EH
A
R
K
ID
DI
F
GDN
VP
N
MSH
S
G
IMEDIKKA
fig|585056.7.peg.787
Escherichia coli UMN026
MSLFRRNEIWYASY
S
LP
G
GKR
I
KESLGTKDKRQA
Q
ELHDK
R
KAE
L
W
R
V
E
KLG
-
----
-
D
L
P
-
-
-
--
--
--
----
DVT
F
EEA
CL
RWL
E
EK
A-
-
-D
K
K
SLD
S
DKSRI
E
FWL
E
HF
E
G
IR
L
KD
I
S
E
AK
I
Y
SAV
S
R
M
H
NR
KTK
E
I
WK
Q
KV
QA
AIR
KGK
EL
P
VYEPKPV-
---
S
TQ
TKA
K
HLA
M
I
K
AILRAAE
R
D
W
K
W
L
EK
AP
VI
KI
PAV
R
NK
R
V-
-
RWL
EKE
EA
K
RLIDEC
-
P
EP
L
KSVV
KF
ALATGLR
K
SNI
I
NL
E
WQQIDMQ
R
RV
AW
V
NPE
E
SK
-
--
--
-
---
-
-
-
SNRAIGVALNDTAC
K
VLR
D
Q
I--
---
-
-
-
-
-
-
-
-
-
------
GKH
HKWVFVH
TKAAKR--
-
--A
D
GTST
PAVR
K
MR
I
D
SK
T
S
W
L
SA
C
RRAGI
E
DFR
F
HDLRHTWASWLI
Q
S
GVPLSVLQ
E
MGGWESIEMV
-
R
RYA
H
LA
P
NHL
T
EH
A
R
K
ID
DI
F
GDN
VP
N
MSH
S
G
IMEDIKKA
fig|413997.3.peg.518
Escherichia coli B str. REL606
MSLFRRNEIWYASY
S
LP
G
GKR
I
KESLGTKDKRQA
Q
ELHDK
R
KAE
L
W
R
V
E
KLG
-
----
-
D
L
P
-
-
-
--
--
--
----
DVT
F
EEA
CL
RWL
E
EK
A-
-
-D
K
K
SLD
S
DKSRI
E
FWL
E
HF
E
G
IR
L
KD
I
S
E
AK
I
Y
SAV
S
R
M
H
NR
KTK
E
I
WK
Q
KV
QA
AIR
KGK
EL
P
VYEPKPV-
---
P
TQ
TKA
K
HLA
M
I
K
AILRAAE
R
D
W
K
W
L
EK
AP
VI
KI
PAV
R
NK
R
V-
-
RWL
EKE
EA
K
RLIDEC
-
P
EP
L
KSVV
KF
ALATGLR
K
SNI
I
NL
E
WQQIDMQ
R
RV
AW
V
NPE
E
SK
-
--
--
-
---
-
-
-
SNRAIGVALNDTAC
K
VLR
D
Q
I--
---
-
-
-
-
-
-
-
-
-
------
GKH
HKWVFVH
TKAAKR--
-
--A
D
GTST
PAVR
K
MR
I
D
SK
T
S
W
L
SA
C
RRAGI
E
DFR
F
HDLRHTWASWLI
Q
S
GVPLSVLQ
E
MGGWESIEMV
-
R
RYA
H
LA
P
NHL
T
EH
A
R
K
ID
DI
F
GDN
VP
N
MSH
S
G
IMEDIKKA
fig|511693.5.peg.524
Escherichia coli BL21
MSLFRRNEIWYASY
S
LP
G
GKR
I
KESLGTKDKRQA
Q
ELHDK
R
KAE
L
W
R
V
E
KLG
-
----
-
D
L
P
-
-
-
--
--
--
----
DVT
F
EEA
CL
RWL
E
EK
A-
-
-D
K
K
SLD
S
DKSRI
E
FWL
E
HF
E
G
IR
L
KD
I
S
E
AK
I
Y
SAV
S
R
M
H
NR
KTK
E
I
WK
Q
KV
QA
AIR
KGK
EL
P
VYEPKPV-
---
P
TQ
TKA
K
HLA
M
I
K
AILRAAE
R
D
W
K
W
L
EK
AP
VI
KI
PAV
R
NK
R
V-
-
RWL
EKE
EA
K
RLIDEC
-
P
EP
L
KSVV
KF
ALATGLR
K
SNI
I
NL
E
WQQIDMQ
R
RV
AW
V
NPE
E
SK
-
--
--
-
---
-
-
-
SNRAIGVALNDTAC
K
VLR
D
Q
I--
---
-
-
-
-
-
-
-
-
-
------
GKH
HKWVFVH
TKAAKR--
-
--A
D
GTST
PAVR
K
MR
I
D
SK
T
S
W
L
SA
C
RRAGI
E
DFR
F
HDLRHTWASWLI
Q
S
GVPLSVLQ
E
MGGWESIEMV
-
R
RYA
H
LA
P
NHL
T
EH
A
R
K
ID
DI
F
GDN
VP
N
MSH
S
G
IMEDIKKA
fig|469008.4.peg.3227
Escherichia coli BL21(DE3)
MSLFRRNEIWYASY
S
LP
G
GKR
I
KESLGTKDKRQA
Q
ELHDK
R
KAE
L
W
R
V
E
KLG
-
----
-
D
L
P
-
-
-
--
--
--
----
DVT
F
EEA
CL
RWL
E
EK
A-
-
-D
K
K
SLD
S
DKSRI
E
FWL
E
HF
E
G
IR
L
KD
I
S
E
AK
I
Y
SAV
S
R
M
H
NR
KTK
E
I
WK
Q
KV
QA
AIR
KGK
EL
P
VYEPKPV-
---
P
TQ
TKA
K
HLA
M
I
K
AILRAAE
R
D
W
K
W
L
EK
AP
VI
KI
PAV
R
NK
R
V-
-
RWL
EKE
EA
K
RLIDEC
-
P
EP
L
KSVV
KF
ALATGLR
K
SNI
I
NL
E
WQQIDMQ
R
RV
AW
V
NPE
E
SK
-
--
--
-
---
-
-
-
SNRAIGVALNDTAC
K
VLR
D
Q
I--
---
-
-
-
-
-
-
-
-
-
------
GKH
HKWVFVH
TKAAKR--
-
--A
D
GTST
PAVR
K
MR
I
D
SK
T
S
W
L
SA
C
RRAGI
E
DFR
F
HDLRHTWASWLI
Q
S
GVPLSVLQ
E
MGGWESIEMV
-
R
RYA
H
LA
P
NHL
T
EH
A
R
K
ID
DI
F
GDN
VP
N
MSH
S
G
IMEDIKKA
fig|637912.3.peg.623
Escherichia coli OP50
MSLFRRNEIWYASY
S
LP
G
GKR
I
KESLGTKDKRQA
Q
ELHDK
R
KAE
L
W
R
V
E
KLG
-
----
-
D
L
P
-
-
-
--
--
--
----
DVT
F
EEA
CL
RWL
E
EK
A-
-
-D
K
K
SLD
S
DKSRI
E
FWL
E
HF
E
G
IR
L
KD
I
S
E
AK
I
Y
SAV
S
R
M
H
NR
KTK
E
I
WK
Q
KV
QA
AIR
KGK
EL
P
VYEPKPV-
---
P
TQ
TKA
K
HLA
M
I
K
AILRAAE
R
D
W
K
W
L
EK
AP
VI
KI
PAV
R
NK
R
V-
-
RWL
EKE
EA
K
RLIDEC
-
P
EP
L
KSVV
KF
ALATGLR
K
SNI
I
NL
E
WQQIDMQ
R
RV
AW
V
NPE
E
SK
-
--
--
-
---
-
-
-
SNRAIGVALNDTAC
K
VLR
D
Q
I--
---
-
-
-
-
-
-
-
-
-
------
GKH
HKWVFVH
TKAAKR--
-
--A
D
GTST
PAVR
K
MR
I
D
SK
T
S
W
L
SA
C
RRAGI
E
DFR
F
HDLRHTWASWLI
Q
S
GVPLSVLQ
E
MGGWESIEMV
-
R
RYA
H
LA
P
NHL
T
EH
A
R
K
ID
DI
F
GDN
VP
N
MSH
S
G
IMEDIKKA
fig|409438.11.peg.690
Escherichia coli SE11
MSLFRRNEIWYASY
S
LP
G
GKR
T
KESLGTKDKRQA
Q
ELHDK
R
KAE
L
W
R
V
E
KLG
-
----
-
D
L
P
-
-
-
--
--
--
----
DVT
F
EEA
CL
RWL
E
EK
A-
-
-D
K
K
SLD
S
DKSRI
E
FWL
E
HF
E
G
IR
L
KD
I
S
E
AK
I
Y
SAV
S
R
M
H
NR
KTK
E
I
WK
Q
KV
QA
AIR
KGK
EL
P
VYEPKPV-
---
S
TQ
TKA
K
HLA
M
I
K
AILRAAE
R
D
W
K
W
L
EK
AP
VI
KI
PAV
R
NK
R
V-
-
RWL
EKE
EA
K
RLIDEC
-
P
EP
L
KSVV
KF
ALATGLR
K
SNI
I
NL
E
WQQIDMQ
R
RV
AW
V
NPE
E
SK
-
--
--
-
---
-
-
-
SNRAIGVALNDTAC
K
VLR
D
Q
I--
---
-
-
-
-
-
-
-
-
-
------
GKH
HKWVFVH
TKAAKR--
-
--A
D
GTST
PAVR
K
MR
I
D
SK
T
S
W
L
SA
C
RRAGI
E
DFR
F
HDLRHTWASWLI
Q
S
GVPLSVLQ
E
MGGWESIEMV
-
R
RYA
H
LA
P
NHL
T
EH
A
R
K
ID
DI
F
GDN
VP
N
MSH
S
G
IMEDIKKA
fig|550676.3.peg.1346
Escherichia coli B185
MSLFRRNEIWYASY
S
LP
G
GKR
I
KESLGTKDKRQA
Q
ELHDK
R
KAE
L
W
R
V
E
K
P
G
-
----
-
D
L
P
-
-
-
--
--
--
----
DVT
F
EEA
CL
RWL
E
EK
A-
-
-D
K
K
SLD
S
DKSRI
E
FWL
E
HF
E
G
IR
L
KD
I
S
E
AK
I
Y
SAV
S
R
M
H
NR
KTK
E
I
WK
Q
KV
QA
AIR
KGK
EL
P
VYEPKPV-
---
S
TQ
TKA
K
HLA
M
I
K
AILRAAE
R
D
W
K
W
L
EK
AP
VI
KI
PAV
R
NK
R
V-
-
RWL
EKE
EA
K
RLIDEC
-
P
EP
L
KSVV
KF
ALATGLR
K
SNI
I
NL
E
WQQIDMQ
R
RV
AW
V
NPE
E
SK
-
--
--
-
---
-
-
-
SNRAIGVALNDTAC
K
VLR
D
Q
I--
---
-
-
-
-
-
-
-
-
-
------
GKH
HKWVFVH
TKAAKR--
-
--A
D
GTST
PAVR
K
MR
I
D
SK
T
S
W
L
SA
C
RRAGI
E
DFR
F
HDLRHTWASWLI
Q
S
GVPLSVLQ
E
MGGWESIEMV
-
R
RYA
H
LA
P
NHL
T
EH
A
R
K
ID
DI
F
GDN
VP
N
MSH
S
G
IMEDIKKA
fig|562.376.peg.614
Escherichia coli WV_060327
MSLFRRNEIWYASY
S
LP
G
GKR
I
KESLGTKDKRQA
Q
ELHDK
R
KAE
L
W
R
V
E
KLG
-
----
-
D
L
P
-
-
-
--
--
--
----
DVT
F
EEA
CL
RWL
E
EK
A-
-
-D
K
K
SLD
S
DKSRI
E
F
R
L
E
HF
E
G
IR
L
KD
I
S
E
AK
I
Y
SAV
S
R
M
H
NR
KTK
E
I
WK
Q
KV
QA
AIR
KGK
EL
P
VYEPKPV-
---
S
TQ
TKA
K
HLA
M
I
K
AILRAAE
R
D
W
K
W
L
EK
AP
VI
KI
PAV
R
NK
R
V-
-
RWL
EKE
EA
K
RLIDEC
-
P
EP
L
KSVV
KF
ALATGLR
K
SNI
I
NL
E
WQQIDMQ
R
RV
AW
V
NPE
E
SK
-
--
--
-
---
-
-
-
SNRAIGVALNDTAC
K
VLR
D
Q
I--
---
-
-
-
-
-
-
-
-
-
------
GKH
HKWVFVH
TKAAKR--
-
--A
D
GTST
PAVR
K
MR
I
D
SK
T
S
W
L
SA
C
RRAGI
E
DFR
F
HDLRHTWASWLI
Q
S
GVPLSVLQ
E
MGGWESIEMV
-
R
RYA
H
LA
P
NHL
T
EH
A
R
K
ID
DI
F
GDN
VP
N
MSH
S
G
IMEDIKKA
fig|562.372.peg.2827
Escherichia coli 1212A (1-377/387)
MSLFRR
G
EIWYAS
F
T
LP
N
GKR
F
K
Q
SLGTKDKRQA
T
ELHDKLKAE
A
W
R
V
S
KLG
-
----
-
E
I
P
-
-
-
--
--
--
----
D
I
T
F
EEA
CV
RWL
E
EK
A-
-
-H
K
K
SLD
D
DKSRI
G
FWL
Q
HF
A
G
MQ
L
RD
I
T
E
SK
I
Y
SA
M
Q
KM
T
NR
RHE
E
N
WKL
RA
E
A
CRK
KGK
PV
P
EYTPKPA-
---
S
VA
TKA
T
HL
S
F
I
K
A
L
LRAAE
R
E
W
K
M
L
DK
AP
II
K
V
PQP
K
NK
R
I-
-
RWL
EPH
EA
Q
RLIDEC
-
P
EP
L
KSVV
EF
ALATGLR
R
SNI
I
NL
E
WQQIDMQ
R
RV
AW
INPE
E
SK
-
--
--
-
---
-
-
-
SNRAIGVALNDTAC
R
VL
K
K
Q
I--
---
-
-
-
-
-
-
-
-
-
------
GNH
H
R
WVFV
Y
KESCTK--
-
--P
D
GTKA
P
T
VR
K
MR
Y
D
AN
T
A
W
K
A
A
L
RRAGI
D
DFR
F
HDLRHTWASWL
V
Q
AGVPLSVLQ
E
MGGWESIEMV
-
R
RYA
H
LA
P
NHL
T
EH
A
R
Q
ID
SI
L
NPS
VP
N
L
S
Q
fig|562.374.peg.1373
Escherichia coli 536A (1-377/387)
MSLFRR
G
EIWYAS
F
T
LP
N
GKR
F
K
Q
SLGTKDKRQA
T
ELHDKLKAE
A
W
R
V
S
KLG
-
----
-
E
I
P
-
-
-
--
--
--
----
D
I
T
F
EEA
CV
RWL
E
EK
A-
-
-H
K
K
SLD
D
DKSRI
G
FWL
Q
HF
A
G
MQ
L
RD
I
T
E
SK
I
Y
SA
M
Q
KM
T
NR
RHE
E
N
WKL
RA
E
A
CRK
KGK
PV
P
EYTPKPA-
---
S
VA
TKA
T
HL
S
F
I
K
A
L
LRAAE
R
E
W
K
M
L
DK
AP
II
K
V
PQP
K
NK
R
I-
-
RWL
EPH
EA
Q
RLIDEC
-
P
EP
L
KSVV
EF
ALATGLR
R
SNI
I
NL
E
WQQIDMQ
R
RV
AW
INPE
E
SK
-
--
--
-
---
-
-
-
SNRAIGVALNDTAC
R
VL
K
K
Q
I--
---
-
-
-
-
-
-
-
-
-
------
GNH
H
R
WVFV
Y
KESCTK--
-
--P
D
GTKA
P
T
VR
K
MR
Y
D
AN
T
A
W
K
A
A
L
RRAGI
D
DFR
F
HDLRHTWASWL
V
Q
AGVPLSVLQ
E
MGGWESIEMV
-
R
RYA
H
LA
P
NHL
T
EH
A
R
Q
ID
SI
L
NPS
VP
N
L
S
Q
fig|340185.4.peg.1577
Escherichia coli E22 (1-377/387)
MSLFRR
G
EIWYAS
F
T
LP
N
GKR
F
K
Q
SLGTKDKRQA
T
ELHDKLKAE
A
W
R
V
S
KLG
-
----
-
E
I
P
-
-
-
--
--
--
----
D
I
T
F
EEA
CV
RWL
E
EK
A-
-
-H
K
K
SLD
D
DKSRI
G
FWL
Q
HF
A
G
MQ
L
RD
I
T
E
SK
I
Y
SA
M
Q
KM
T
NR
RHE
E
N
WKL
RA
E
A
CRK
KGK
PV
P
EYTPKPA-
---
S
VA
TKA
T
HL
S
F
I
K
A
L
LRAAE
R
E
W
K
M
L
DK
AP
II
K
V
PQP
K
NK
R
I-
-
RWL
EPH
EA
Q
RLIDEC
-
P
EP
L
KSVV
EF
ALATGLR
R
SNI
I
NL
E
WQQIDMQ
R
RV
AW
INPE
E
SK
-
--
--
-
---
-
-
-
SNRAIGVALNDTAC
R
VL
K
K
Q
I--
---
-
-
-
-
-
-
-
-
-
------
GNH
H
R
WVFV
Y
KESCTK--
-
--P
D
GTKA
P
T
VR
K
MR
Y
D
AN
T
A
W
K
A
A
L
RRAGI
D
DFR
F
HDLRHTWASWL
V
Q
AGVPLSVLQ
E
MGGWESIEMV
-
R
RYA
H
LA
P
NHL
T
EH
A
R
Q
ID
SI
L
NPS
VP
N
L
S
Q
fig|679206.4.peg.3230
Escherichia coli MS 119-7 (1-377/387)
MSLFRR
G
EIWYAS
F
T
LP
N
GKR
F
K
Q
SLGTKDKRQA
T
ELHDKLKAE
A
W
R
V
S
KLG
-
----
-
E
I
P
-
-
-
--
--
--
----
D
I
T
F
EEA
CV
RWL
E
EK
A-
-
-H
K
K
SLD
D
DKSRI
G
FWL
Q
HF
A
G
MQ
L
RD
I
T
E
SK
I
Y
SA
M
Q
KM
T
NR
RHE
E
N
WKL
RA
E
A
CRK
KGK
PV
P
EYTPKPA-
---
S
VA
TKA
T
HL
S
F
I
K
A
L
LRAAE
R
E
W
K
M
L
DK
AP
II
K
V
PQP
K
NK
R
I-
-
RWL
EPH
EA
Q
RLIDEC
-
P
EP
L
KSVV
EF
ALATGLR
R
SNI
I
NL
E
WQQIDMQ
R
RV
AW
INPE
E
SK
-
--
--
-
---
-
-
-
SNRAIGVALNDTAC
R
VL
K
K
Q
I--
---
-
-
-
-
-
-
-
-
-
------
GNH
H
R
WVFV
Y
KESCTK--
-
--P
D
GTKA
P
T
VR
K
MR
Y
D
AN
T
A
W
K
A
A
L
RRAGI
D
DFR
F
HDLRHTWASWL
V
Q
AGVPLSVLQ
E
MGGWESIEMV
-
R
RYA
H
LA
P
NHL
T
EH
A
R
Q
ID
SI
L
NPS
VP
N
L
S
Q
fig|749531.3.peg.1453
Escherichia coli MS 69-1 (1-377/387)
MSLFRR
G
EIWYAS
F
T
LP
N
GKR
F
K
Q
SLGTKDKRQA
T
ELHDKLKAE
A
W
R
V
S
KLG
-
----
-
E
I
P
-
-
-
--
--
--
----
D
I
T
F
EEA
CV
RWL
E
EK
A-
-
-H
K
K
SLD
D
DKSRI
G
FWL
Q
HF
A
G
MQ
L
RD
I
T
E
SK
I
Y
SA
M
Q
KM
T
NR
RHE
E
N
WKL
RA
E
A
CRK
KGK
PV
P
EYTPKPA-
---
S
VA
TKA
T
HL
S
F
I
K
A
L
LRAAE
R
E
W
K
M
L
DK
AP
II
K
V
PQP
K
NK
R
I-
-
RWL
EPH
EA
Q
RLIDEC
-
P
EP
L
KSVV
EF
ALATGLR
R
SNI
I
NL
E
WQQIDMQ
R
RV
AW
INPE
E
SK
-
--
--
-
---
-
-
-
SNRAIGVALNDTAC
R
VL
K
K
Q
I--
---
-
-
-
-
-
-
-
-
-
------
GNH
H
R
WVFV
Y
KESCTK--
-
--P
D
GTKA
P
T
VR
K
MR
Y
D
AN
T
A
W
K
A
A
L
RRAGI
D
DFR
F
HDLRHTWASWL
V
Q
AGVPLSVLQ
E
MGGWESIEMV
-
R
RYA
H
LA
P
NHL
T
EH
A
R
Q
ID
SI
L
NPS
VP
N
L
S
Q
fig|749532.3.peg.490
Escherichia coli MS 78-1 (1-377/387)
MSLFRR
G
EIWYAS
F
T
LP
N
GKR
F
K
Q
SLGTKDKRQA
T
ELHDKLKAE
A
W
R
V
S
KLG
-
----
-
E
I
P
-
-
-
--
--
--
----
D
I
T
F
EEA
CV
RWL
E
EK
A-
-
-H
K
K
SLD
D
DKSRI
G
FWL
Q
HF
A
G
MQ
L
RD
I
T
E
SK
I
Y
SA
M
Q
KM
T
NR
RHE
E
N
WKL
RA
E
A
CRK
KGK
PV
P
EYTPKPA-
---
S
VA
TKA
T
HL
S
F
I
K
A
L
LRAAE
R
E
W
K
M
L
DK
AP
II
K
V
PQP
K
NK
R
I-
-
RWL
EPH
EA
Q
RLIDEC
-
P
EP
L
KSVV
EF
ALATGLR
R
SNI
I
NL
E
WQQIDMQ
R
RV
AW
INPE
E
SK
-
--
--
-
---
-
-
-
SNRAIGVALNDTAC
R
VL
K
K
Q
I--
---
-
-
-
-
-
-
-
-
-
------
GNH
H
R
WVFV
Y
KESCTK--
-
--P
D
GTKA
P
T
VR
K
MR
Y
D
AN
T
A
W
K
A
A
L
RRAGI
D
DFR
F
HDLRHTWASWL
V
Q
AGVPLSVLQ
E
MGGWESIEMV
-
R
RYA
H
LA
P
NHL
T
EH
A
R
Q
ID
SI
L
NPS
VP
N
L
S
Q
fig|478008.5.peg.4769
Escherichia coli O157:H7 str. EC869 (1-377/387)
MSLFRR
G
EIWYAS
F
T
LP
N
GKR
F
K
Q
SLGTKDKRQA
T
ELHDKLKAE
A
W
R
V
S
KLG
-
----
-
E
I
P
-
-
-
--
--
--
----
D
I
T
F
EEA
CV
RWL
E
EK
A-
-
-H
K
K
SLD
D
DKSRI
G
FWL
Q
HF
A
G
MQ
L
RD
I
T
E
SK
I
Y
SA
M
Q
KM
T
NR
RHE
E
N
WKL
RA
E
A
CRK
KGK
PV
P
EYTPKPA-
---
S
VA
TKA
T
HL
S
F
I
K
A
L
LRAAE
R
E
W
K
M
L
DK
AP
II
K
V
PQP
K
NK
R
I-
-
RWL
EPH
EA
Q
RLIDEC
-
P
EP
L
KSVV
EF
ALATGLR
R
SNI
I
NL
E
WQQIDMQ
R
RV
AW
INPE
E
SK
-
--
--
-
---
-
-
-
SNRAIGVALNDTAC
R
VL
K
K
Q
I--
---
-
-
-
-
-
-
-
-
-
------
GNH
H
R
WVFV
Y
KESCTK--
-
--P
D
GTKA
P
T
VR
K
MR
Y
D
AN
T
A
W
K
A
A
L
RRAGI
D
DFR
F
HDLRHTWASWL
V
Q
AGVPLSVLQ
E
MGGWESIEMV
-
R
RYA
H
LA
P
NHL
T
EH
A
R
Q
ID
SI
L
NPS
VP
N
L
S
Q
fig|637388.3.peg.750
Escherichia coli O157:H7 str. FRIK2000 (1-377/387)
MSLFRR
G
EIWYAS
F
T
LP
N
GKR
F
K
Q
SLGTKDKRQA
T
ELHDKLKAE
A
W
R
V
S
KLG
-
----
-
E
I
P
-
-
-
--
--
--
----
D
I
T
F
EEA
CV
RWL
E
EK
A-
-
-H
K
K
SLD
D
DKSRI
G
FWL
Q
HF
A
G
MQ
L
RD
I
T
E
SK
I
Y
SA
M
Q
KM
T
NR
RHE
E
N
WKL
RA
E
A
CRK
KGK
PV
P
EYTPKPA-
---
S
VA
TKA
T
HL
S
F
I
K
A
L
LRAAE
R
E
W
K
M
L
DK
AP
II
K
V
PQP
K
NK
R
I-
-
RWL
EPH
EA
Q
RLIDEC
-
P
EP
L
KSVV
EF
ALATGLR
R
SNI
I
NL
E
WQQIDMQ
R
RV
AW
INPE
E
SK
-
--
--
-
---
-
-
-
SNRAIGVALNDTAC
R
VL
K
K
Q
I--
---
-
-
-
-
-
-
-
-
-
------
GNH
H
R
WVFV
Y
KESCTK--
-
--P
D
GTKA
P
T
VR
K
MR
Y
D
AN
T
A
W
K
A
A
L
RRAGI
D
DFR
F
HDLRHTWASWL
V
Q
AGVPLSVLQ
E
MGGWESIEMV
-
R
RYA
H
LA
P
NHL
T
EH
A
R
Q
ID
SI
L
NPS
VP
N
L
S
Q
fig|570506.3.peg.1745
Escherichia coli O157:H7 str. FRIK966 (1-377/387)
MSLFRR
G
EIWYAS
F
T
LP
N
GKR
F
K
Q
SLGTKDKRQA
T
ELHDKLKAE
A
W
R
V
S
KLG
-
----
-
E
I
P
-
-
-
--
--
--
----
D
I
T
F
EEA
CV
RWL
E
EK
A-
-
-H
K
K
SLD
D
DKSRI
G
FWL
Q
HF
A
G
MQ
L
RD
I
T
E
SK
I
Y
SA
M
Q
KM
T
NR
RHE
E
N
WKL
RA
E
A
CRK
KGK
PV
P
EYTPKPA-
---
S
VA
TKA
T
HL
S
F
I
K
A
L
LRAAE
R
E
W
K
M
L
DK
AP
II
K
V
PQP
K
NK
R
I-
-
RWL
EPH
EA
Q
RLIDEC
-
P
EP
L
KSVV
EF
ALATGLR
R
SNI
I
NL
E
WQQIDMQ
R
RV
AW
INPE
E
SK
-
--
--
-
---
-
-
-
SNRAIGVALNDTAC
R
VL
K
K
Q
I--
---
-
-
-
-
-
-
-
-
-
------
GNH
H
R
WVFV
Y
KESCTK--
-
--P
D
GTKA
P
T
VR
K
MR
Y
D
AN
T
A
W
K
A
A
L
RRAGI
D
DFR
F
HDLRHTWASWL
V
Q
AGVPLSVLQ
E
MGGWESIEMV
-
R
RYA
H
LA
P
NHL
T
EH
A
R
Q
ID
SI
L
NPS
VP
N
L
S
Q
fig|316401.4.peg.304
Escherichia coli ETEC H10407 (1-377/387)
MSLFRR
G
EIWYAS
F
T
LP
N
GKR
F
K
Q
SLGTKDKRQA
T
ELHDKLKAE
A
W
R
V
S
KLG
-
----
-
E
I
P
-
-
-
--
--
--
----
D
I
T
F
EEA
CV
RWL
E
EK
A-
-
-H
K
K
SLD
D
DKSRI
G
FWL
Q
HF
A
G
MQ
L
RD
I
T
E
SK
I
Y
SA
M
Q
KM
T
NR
RHE
E
N
WKL
RA
E
A
CRK
KGK
PV
P
EYTPKPA-
---
S
VA
TKA
T
HL
S
F
I
K
A
L
LRAAE
R
E
W
K
M
L
DK
AP
II
K
V
PQP
K
NK
R
I-
-
RWL
EPH
EA
Q
RLIDEC
-
P
EP
L
KSVV
EF
ALATGLR
R
SNI
I
NL
E
WQQIDMQ
R
RV
AW
INPE
E
SK
-
--
--
-
---
-
-
-
SNRAIGVALNDTAC
R
VL
K
K
Q
I--
---
-
-
-
-
-
-
-
-
-
------
GNH
H
R
WVFV
Y
KESCTK--
-
--P
D
GTKA
P
T
VR
K
MR
Y
D
AN
T
A
W
K
A
A
L
RRAGI
D
DFR
F
HDLRHTWASWL
V
Q
AGVPLSVLQ
E
MGGWESIEMV
-
R
RYA
H
LA
P
NHL
T
EH
A
R
Q
ID
SI
L
NPS
VP
N
L
S
Q
fig|679207.4.peg.2243
Escherichia coli MS 107-1 (1-377/387)
MSLFRR
G
EIWYAS
F
T
LP
N
GKR
F
K
Q
SLGTKDKRQA
T
ELHDKLKAE
A
W
R
V
S
KLG
-
----
-
E
I
P
-
-
-
--
--
--
----
D
I
T
F
EEA
CV
RWL
E
EK
A-
-
-H
K
K
SLD
D
DKSRI
G
FWL
Q
HF
A
G
MQ
L
RD
I
T
E
SK
I
Y
SA
M
H
KM
T
NR
RHE
E
N
WKL
RA
E
A
CRK
KGK
PV
P
EYTPKPA-
---
S
VA
TKA
T
HL
S
F
I
K
A
L
LRAAE
R
E
W
K
M
L
DK
AP
II
K
V
PQP
K
NK
R
I-
-
RWL
EPH
EA
Q
RLIDEC
-
P
EP
L
KSVV
EF
ALATGLR
R
SNI
I
NL
E
WQQIDMQ
R
RV
AW
INPE
E
SK
-
--
--
-
---
-
-
-
SNRAIGVALNDTAC
R
VL
K
K
Q
I--
---
-
-
-
-
-
-
-
-
-
------
GNH
H
R
WVFV
Y
KESCTK--
-
--P
D
GTKA
P
T
VR
K
MR
Y
D
AN
T
A
W
K
A
A
L
RRAGI
D
DFR
F
HDLRHTWASWL
V
Q
AGVPLSVLQ
E
MGGWESIEMV
-
R
RYA
H
LA
P
NHL
T
EH
A
R
Q
ID
SI
L
NPS
VP
N
L
S
Q
fig|749545.3.peg.245
Escherichia coli MS 182-1 (1-377/387)
MSLFRR
S
EIWYAS
F
T
LP
N
GKR
F
K
Q
SLGTKDKRQA
T
ELHDKLKAE
A
W
R
V
S
KLG
-
----
-
E
I
P
-
-
-
--
--
--
----
D
M
T
F
EEA
CI
RWL
E
EK
A-
-
-H
K
K
SLD
D
DKSRI
G
FWL
Q
HF
A
G
MQ
L
RD
I
T
E
SK
I
Y
SA
M
Q
KM
T
NR
RHE
E
N
WKL
RA
E
A
CRK
KGK
PV
P
EYTPKPA-
---
S
VA
TKA
T
HL
S
F
I
K
A
L
LRAAE
R
E
W
K
M
L
DK
AP
II
K
V
PQP
K
NK
R
I-
-
RWL
EPH
EA
Q
RLIDEC
-
P
EP
L
KSVV
EF
ALATGLR
R
SNI
I
NL
E
WQQIDMQ
R
RV
AW
INPE
E
SK
-
--
--
-
---
-
-
-
SNRAIGVALNDTAC
R
VL
K
K
Q
I--
---
-
-
-
-
-
-
-
-
-
------
GNH
H
R
WVFV
Y
KESCTK--
-
--P
D
GTKA
P
T
VR
K
MR
Y
D
AN
T
A
W
K
A
A
L
RRAGI
D
DFR
F
HDLRHTWASWL
V
Q
AGVPLSVLQ
E
MGGWESIEMV
-
R
RYA
H
LA
P
NHL
T
EH
A
R
Q
ID
SI
L
NPS
VP
N
L
S
Q
fig|679205.4.peg.539
Escherichia coli MS 124-1 (1-377/387)
MSLFRR
G
EIWYAS
F
T
LP
N
GKR
F
K
Q
SLGTKDKRQA
T
ELHDKLKAE
A
W
R
V
S
KLG
-
----
-
E
I
P
-
-
-
--
--
--
----
D
I
T
F
EEA
CI
RWL
E
EK
A-
-
-H
K
K
SLD
D
DKSRI
G
FWL
Q
HF
A
G
MQ
L
RD
I
T
E
SK
I
Y
SA
M
Q
KM
T
NR
RHE
E
N
W
R
L
RA
E
A
CRK
KGK
PV
P
EYTPKPA-
---
S
VA
TKA
T
HL
S
F
I
K
A
L
LRAAE
R
E
W
K
M
L
DK
AP
II
K
V
PQP
K
NK
R
I-
-
RWL
EPH
EA
Q
RLIDEC
-
P
EP
L
KSVV
EF
ALATGLR
R
SNI
I
NL
E
WQQIDMQ
R
RV
AW
INPE
E
SK
-
--
--
-
---
-
-
-
SNRAIGVALNDTAC
R
VL
K
K
Q
I--
---
-
-
-
-
-
-
-
-
-
------
GNH
H
R
WVFV
Y
KESCTK--
-
--P
D
GTKA
P
T
VR
K
MR
Y
D
AN
T
A
W
K
A
A
L
RRAGI
D
DFR
F
HDLRHTWASWL
V
Q
AGVPLSVLQ
E
MGGWESIEMV
-
R
RYA
H
LA
P
NHL
T
EH
A
R
Q
ID
SI
L
NPS
VP
N
S
S
Q
fig|749533.3.peg.685
Escherichia coli MS 84-1 (1-377/387)
MSLFRR
G
EIWYAS
F
T
LP
N
GKR
F
K
Q
SLGTKDKRQA
T
ELHDKLKAE
A
W
R
V
S
KLG
-
----
-
E
I
P
-
-
-
--
--
--
----
D
I
T
F
EEA
CI
RWL
E
EK
A-
-
-H
K
K
SLD
D
DKSRI
G
FWL
Q
HF
A
G
MQ
L
RD
I
T
E
SK
I
Y
SA
M
Q
KM
T
NR
RHE
E
N
W
R
L
RA
E
A
CRK
KGK
PV
P
EYTPKPA-
---
S
VA
TKA
T
HL
S
F
I
K
A
L
LRAAE
R
E
W
K
M
L
DK
AP
II
K
V
PQP
K
NK
R
I-
-
RWL
EPH
EA
Q
RLIDEC
-
P
EP
L
KSVV
EF
ALATGLR
R
SNI
I
NL
E
WQQIDMQ
R
RV
AW
INPE
E
SK
-
--
--
-
---
-
-
-
SNRAIGVALNDTAC
R
VL
K
K
Q
I--
---
-
-
-
-
-
-
-
-
-
------
GNH
H
R
WVFV
Y
KESCTK--
-
--P
D
GTKA
P
T
VR
K
MR
Y
D
AN
T
A
W
K
A
A
L
RRAGI
D
DFR
F
HDLRHTWASWL
V
Q
AGVPLSVLQ
E
MGGWESIEMV
-
R
RYA
H
LA
P
NHL
T
EH
A
R
Q
ID
SI
L
NPS
VP
N
S
S
Q
fig|358709.5.peg.2856
Escherichia coli 101-1 (1-377/387)
MSLFRR
S
EIWYAS
F
T
LP
N
GKR
F
K
Q
SLGTKDKRQA
T
ELHDKLKAE
A
W
R
V
S
KLG
-
----
-
E
I
P
-
-
-
--
--
--
----
D
M
T
F
EEA
CV
RWL
E
EK
A-
-
-H
K
K
SLD
D
DKSRI
G
FWL
Q
HF
A
G
MQ
L
RD
I
T
E
SK
I
Y
SA
M
Q
KM
T
NR
RHE
E
N
WKL
RA
E
A
CRK
KGK
PV
P
EYTPKPA-
---
S
VA
TKA
T
HL
S
F
I
K
A
L
LRAAE
R
E
W
K
M
L
DK
AP
II
K
V
PQP
K
NK
R
I-
-
RWL
EPH
EA
Q
RLIDEC
-
P
EP
L
KSVV
EF
ALATGLR
R
SNI
I
NL
E
WQQIDMQ
R
RV
AW
INPE
E
SK
-
--
--
-
---
-
-
-
SNRAIGVALNDTAC
R
VL
K
K
Q
I--
---
-
-
-
-
-
-
-
-
-
------
GNH
H
R
WVFV
Y
KESCTK--
-
--P
D
GTKA
P
T
VR
K
MR
Y
D
AN
T
A
W
K
A
A
L
RRAGI
D
DFR
F
HDLRHTWASWL
V
Q
AGVPLSVLQ
E
MGGWESIEMV
-
R
RYA
H
LA
P
NHL
T
EH
A
R
Q
ID
SI
L
NPS
VP
N
L
S
Q
fig|331112.6.peg.266
Escherichia coli HS (1-378/386)
MS
I
KL
R
G
GT
W
H
CD
F
V
A
P
D
G
S
R
V
R
R
SL
E
T
S
DKRQA
Q
ELHD
R
LKAE
A
W
R
V
K
N
LG
-
----
-
E
S
P
-
-
-
--
--
--
----
KKL
F
K
EA
CI
RWL
R
EK
S-
-
-D
K
K
S
I
D
D
DKS
I
I
S
FW
M
L
HF
R
E
TI
L
SD
I
T
T
EK
I
M
E
AV
D
G
M
E
NR
RHR
L
N
W
EM
SR
DR
CLR
L
GK
PV
P
EYKPKLA-
---
S
KG
TK
T
R
HLA
I
L
R
AIL
NM
A
-
V
E
W
G
W
L
DR
AP
KI
ST
PRV
K
NG
R
I-
-
RWL
TEE
E
S
K
RL
FA
E
I
-
A
PH
F
FP
VV
MF
A
I
T
TGLR
R
SN
V
T
D
L
E
W
S
Q
V
D
L
D
K
KM
AW
MH
P
D
E
T
K
-
--
--
-
---
-
-
-
A
GN
AIGV
P
LN
E
TAC
Q
I
LR
K
Q
Q--
---
-
-
-
-
-
-
-
-
-
------
GLH
K
R
WVFVH
TKPAYR--
-
--S
D
GTKT
A
AVR
K
MR
T
D
SN
K
A
W
K
G
A
L
K
RAGI
S
N
FR
F
HDLRHTWASWL
V
Q
S
GV
S
L
LA
L
K
E
MGGWE
TL
EMV
-
Q
RYA
H
L
S
A
G
HL
T
EH
A
S
K
ID
AI
I
SRN
GT
N
T
A
Q
E
E
fig|362663.8.peg.274
Escherichia coli 536 (1-378/386)
MS
I
KL
R
G
GT
W
H
CD
F
V
A
P
D
G
S
R
V
R
R
SL
E
T
S
DKRQA
Q
ELHD
R
LKAE
A
W
R
V
K
N
LG
-
----
-
E
S
P
-
-
-
--
--
--
----
KKL
F
K
EA
CI
RWL
R
EK
S-
-
-D
K
K
S
I
D
D
DKS
I
I
S
FW
M
L
HF
R
E
TI
L
SD
I
T
T
EK
I
M
E
AV
D
G
M
E
NR
RHR
L
N
W
EM
SR
DR
CLR
L
GK
PV
P
EYKPKLA-
---
S
KG
TK
T
R
HLA
I
L
R
AIL
NM
A
-
V
E
W
G
W
L
DR
T
P
KI
ST
PRV
K
NG
R
I-
-
RWL
TEE
E
S
K
RL
FA
E
I
-
A
PH
F
FP
VV
MF
A
I
T
TGLR
R
SN
V
T
D
L
E
W
S
Q
V
D
L
D
K
KM
AW
MH
P
D
E
T
K
-
--
--
-
---
-
-
-
A
GN
AIGV
P
LN
E
TAC
Q
I
LR
K
Q
Q--
---
-
-
-
-
-
-
-
-
-
------
GLH
K
R
WVFVH
TKPAYR--
-
--S
D
GTKT
A
AVR
K
MR
T
D
SN
K
A
W
K
G
A
L
K
RAGI
S
N
FR
F
HDLRHTWASWL
V
Q
S
GV
S
L
LA
L
K
E
MGGWE
TL
EMV
-
Q
RYA
H
L
S
A
G
HL
T
EH
A
S
K
ID
AI
I
SRN
GT
N
T
A
Q
E
E
fig|362663.9.peg.274
Escherichia coli 536 (1-378/386)
MS
I
KL
R
G
GT
W
H
CD
F
V
A
P
D
G
S
R
V
R
R
SL
E
T
S
DKRQA
Q
ELHD
R
LKAE
A
W
R
V
K
N
LG
-
----
-
E
S
P
-
-
-
--
--
--
----
KKL
F
K
EA
CI
RWL
R
EK
S-
-
-D
K
K
S
I
D
D
DKS
I
I
S
FW
M
L
HF
R
E
TI
L
SD
I
T
T
EK
I
M
E
AV
D
G
M
E
NR
RHR
L
N
W
EM
SR
DR
CLR
L
GK
PV
P
EYKPKLA-
---
S
KG
TK
T
R
HLA
I
L
R
AIL
NM
A
-
V
E
W
G
W
L
DR
T
P
KI
ST
PRV
K
NG
R
I-
-
RWL
TEE
E
S
K
RL
FA
E
I
-
A
PH
F
FP
VV
MF
A
I
T
TGLR
R
SN
V
T
D
L
E
W
S
Q
V
D
L
D
K
KM
AW
MH
P
D
E
T
K
-
--
--
-
---
-
-
-
A
GN
AIGV
P
LN
E
TAC
Q
I
LR
K
Q
Q--
---
-
-
-
-
-
-
-
-
-
------
GLH
K
R
WVFVH
TKPAYR--
-
--S
D
GTKT
A
AVR
K
MR
T
D
SN
K
A
W
K
G
A
L
K
RAGI
S
N
FR
F
HDLRHTWASWL
V
Q
S
GV
S
L
LA
L
K
E
MGGWE
TL
EMV
-
Q
RYA
H
L
S
A
G
HL
T
EH
A
S
K
ID
AI
I
SRN
GT
N
T
A
Q
E
E
fig|701177.3.peg.279
Escherichia coli O55:H7 str. CB9615 (1-378/386)
MS
I
KL
R
G
GT
W
H
CD
F
V
AQ
D
G
S
R
V
R
R
SL
E
T
S
DKRQA
Q
ELHD
R
LKAE
A
W
R
V
K
N
LG
-
----
-
E
S
P
-
-
-
--
--
--
----
KKL
F
K
EA
CI
RWL
R
EK
S-
-
-D
K
K
S
I
D
D
DKS
I
I
S
FW
M
L
HF
R
E
TI
L
SD
I
T
T
EK
I
M
E
AV
D
G
M
E
NR
RHR
L
N
W
EM
SR
DR
CLR
L
GK
PV
P
EYKPKLA-
---
S
KG
TK
T
R
HLA
I
L
R
AIL
NM
A
-
V
E
C
G
W
L
DR
AP
KI
ST
PRV
K
NG
R
I-
-
RWL
TEE
E
S
K
RL
FA
E
I
-
A
PH
F
FP
VV
MF
A
I
T
TGLR
R
SN
V
T
D
L
E
W
S
Q
V
D
L
D
K
KM
AW
MH
P
D
E
T
K
-
--
--
-
---
-
-
-
A
GN
AIGV
P
LN
E
TAC
Q
I
LR
K
Q
Q--
---
-
-
-
-
-
-
-
-
-
------
GLH
K
R
WVFVH
TKPAYR--
-
--S
D
GTKT
A
AVR
K
MR
T
D
SN
K
A
W
K
G
A
L
K
RAGI
S
N
FR
F
HDLRHTWASWL
V
Q
S
GV
S
L
LA
L
K
E
MGGWE
TL
EMV
-
Q
RYA
H
L
S
A
G
HL
T
EH
A
S
K
ID
AI
I
SRN
GT
N
T
A
Q
E
E
fig|585395.4.peg.2227
Escherichia coli O103:H2 str. 12009 (25-423/437)
GKR
V
R
E
N
LG
VP
D
TAKN
R
KI
AGE
L
R
T
S
V
C
F
A
I
RT
G
N
FDYA
A
Q
F
P
D
S
P
NL
QA
FG
VSKK
E
I
T
V
K
E
L
EE
K
WL
D
L
K
RM
E
IS
A
N
AFN
R
Y
E
S
VA
R
---
-
--
-
-
TM
V
PK
I
G
G
SR
L
V
S
T
V
T
K
E
E
--
---
-
-
-
L
L
YI
R
K
DLL
T
G
H
QN
P
TKGKAPVK
-
GR
S
VV
T
VN
Y
YM
T
T
I
A
G
M
FQF
A
-
A
D
H
G
Y
L
EA
N
P
FE
G
I
KPL
K
KA
R
AE
PDP
L
TRD
E
F
I
RLID
A
C
R
H
QQ
T
K
NLW
SL
A
VY
TG
M
R
H
GEL
V
S
L
A
W
ED
ID
LK
A
GT
IT
I
RRN
Y
T
K
L
DE
FT
L
PKT
E
A
S
T
NR
V
I
--
H
L
I
Q
P
A
I
S
VL
K
N
Q
AEM
TRL
G
K
Q
H
H
I
K
V
Q
LREYGR
SVN
H
E
CT
FV
F
NPQVVRKS
K
QVG
F
IYKV
D
S
IG
D
S
-
-
-
--
-
-
W
E
SA
I
K
RAGI
R
HRK
A
YQS
RHT
Y
A
C
W
S
L
S
AG
ANP
S
FIA
S
QM
G
HA
S
AQ
MV
F
N
V
Y
G
A
WM
T
D
S
N
A
E
Q
I
A
M
LN
QK
L
ADY
VP
M
MSH
fig|409438.11.peg.2255
Escherichia coli SE11 (25-423/437)
GKR
V
R
E
N
LG
VP
D
TAKN
R
KI
AGE
L
R
T
S
V
C
F
A
I
RT
G
N
FDYA
A
Q
F
P
D
S
P
NL
KA
FG
VNKK
E
I
T
V
K
E
L
EE
K
WL
D
L
K
RM
E
IS
A
N
AFN
R
Y
E
S
VA
R
---
-
--
-
-
TM
V
PK
I
G
G
SR
L
V
S
S
V
T
K
E
E
--
---
-
-
-
L
L
YI
R
K
DLL
T
G
Y
QN
S
TKNKAAAK
-
GR
S
VV
T
VN
Y
YM
T
T
I
A
G
M
FQF
A
-
A
D
H
G
Y
L
EA
N
P
FQ
G
I
KPL
K
RA
R
AE
PDP
L
TRD
E
F
I
RLID
A
C
R
H
QQ
T
K
NLW
SL
A
VY
TG
M
R
H
GEL
V
S
L
A
W
ED
ID
LK
A
GT
IT
I
RRN
Y
T
K
L
GE
FT
L
PKT
E
A
S
T
NR
VV
--
H
L
I
Q
P
A
I
S
VL
K
N
Q
AEM
TRL
G
K
Q
H
H
I
K
V
Q
LREYGR
SVN
H
E
CT
FV
F
NPQVVRKS
K
QVG
F
IYKV
D
S
IG
D
S
-
-
-
--
-
-
W
E
T
A
I
K
RAGI
R
HRK
A
YQS
RHT
Y
A
C
W
S
L
S
AG
ANP
S
FIA
S
QM
G
HA
S
AQ
MV
F
N
V
Y
G
A
WM
T
D
S
N
A
E
Q
I
A
M
LN
QK
L
ADY
VP
M
MSH
fig|344610.3.peg.2968
Escherichia coli 53638 (25-423/437)
GKR
V
R
E
N
LG
VP
D
TAKN
R
KI
AGE
L
R
T
S
V
C
F
A
I
RT
G
S
FDYA
A
Q
F
P
D
S
P
NL
QA
FG
VSKK
E
I
T
V
K
E
L
EE
K
WL
D
L
K
RM
E
IS
A
N
AFN
R
Y
E
S
VA
R
---
-
--
-
-
TM
V
PK
I
G
G
GR
L
V
S
S
V
T
K
E
E
--
---
-
-
-
L
L
YI
R
K
DLL
T
G
Y
QN
S
TKNKAAAK
-
GR
S
VV
T
VN
Y
YM
T
T
I
A
G
M
FQF
A
-
A
D
H
G
Y
L
EA
N
P
FQ
G
I
KPL
K
RA
R
AE
PDP
L
TRD
E
F
I
RLID
A
C
R
H
QQ
T
K
NLW
SL
A
VY
TG
M
R
H
GEL
V
S
L
A
W
ED
ID
LK
A
GT
IT
I
RRN
Y
T
K
L
GE
FT
L
PKT
E
A
S
T
NR
VV
--
H
L
I
Q
P
A
I
S
VL
K
N
Q
AEM
TRL
G
K
Q
H
H
I
K
V
Q
LREYGR
SVN
H
E
CT
FV
F
NPQVVRKS
K
QVG
F
IYKV
D
S
IG
D
S
-
-
-
--
-
-
W
E
T
A
I
K
RAGI
R
HRK
A
YQS
RHT
Y
A
C
W
S
L
S
AG
ANP
S
FIA
S
QM
G
HA
S
AQ
MV
F
N
V
Y
G
A
WM
T
D
S
N
A
E
Q
I
A
M
LN
QK
L
ADY
VP
M
MSH
fig|344610.7.peg.4746
Escherichia coli 53638 (25-423/437)
GKR
V
R
E
N
LG
VP
D
TAKN
R
KI
AGE
L
R
T
S
V
C
F
A
I
RT
G
S
FDYA
A
Q
F
P
D
S
P
NL
QA
FG
VSKK
E
I
T
V
K
E
L
EE
K
WL
D
L
K
RM
E
IS
A
N
AFN
R
Y
E
S
VA
R
---
-
--
-
-
TM
V
PK
I
G
G
GR
L
V
S
S
V
T
K
E
E
--
---
-
-
-
L
L
YI
R
K
DLL
T
G
Y
QN
S
TKNKAAAK
-
GR
S
VV
T
VN
Y
YM
T
T
I
A
G
M
FQF
A
-
A
D
H
G
Y
L
EA
N
P
FQ
G
I
KPL
K
RA
R
AE
PDP
L
TRD
E
F
I
RLID
A
C
R
H
QQ
T
K
NLW
SL
A
VY
TG
M
R
H
GEL
V
S
L
A
W
ED
ID
LK
A
GT
IT
I
RRN
Y
T
K
L
GE
FT
L
PKT
E
A
S
T
NR
VV
--
H
L
I
Q
P
A
I
S
VL
K
N
Q
AEM
TRL
G
K
Q
H
H
I
K
V
Q
LREYGR
SVN
H
E
CT
FV
F
NPQVVRKS
K
QVG
F
IYKV
D
S
IG
D
S
-
-
-
--
-
-
W
E
T
A
I
K
RAGI
R
HRK
A
YQS
RHT
Y
A
C
W
S
L
S
AG
ANP
S
FIA
S
QM
G
HA
S
AQ
MV
F
N
V
Y
G
A
WM
T
D
S
N
A
E
Q
I
A
M
LN
QK
L
ADY
VP
M
MSH
fig|585397.7.peg.2164
Escherichia coli ED1a (25-423/437)
GKR
V
R
E
N
LG
VP
D
TAKN
R
KI
AGE
L
R
T
S
V
C
F
A
I
RT
G
S
FDYA
A
Q
F
P
D
S
P
NL
QA
FG
VSKK
E
I
T
V
K
E
L
EE
K
WL
D
L
K
RM
E
IS
A
N
AFN
R
Y
E
S
VA
R
---
-
--
-
-
TM
V
SK
I
G
G
SR
L
V
S
S
V
T
K
E
E
--
---
-
-
-
L
L
YI
R
K
DLL
T
G
Y
QN
S
TKNKAAAK
-
GR
S
VV
T
VN
Y
YM
T
T
I
A
G
M
FQF
A
-
A
D
H
G
Y
L
EA
N
P
FQ
G
I
KPL
K
RA
R
AE
PDP
L
TRD
E
F
I
RLID
A
C
R
H
QQ
T
K
NLW
SL
A
VY
TG
M
R
H
GEL
V
S
L
A
W
ED
ID
LK
A
GT
IT
I
RRN
Y
T
K
L
GE
FT
L
PKT
E
A
S
T
NR
VV
--
H
L
I
Q
P
A
I
S
VL
K
N
Q
AEM
TRL
G
K
Q
Y
N
I
K
V
Q
LREYGR
SVN
H
E
CT
FV
F
NPQVVRKS
E
QVG
F
VYKV
D
S
V
G
D
S
-
-
-
--
-
-
W
E
T
A
I
K
RAGI
R
HRK
A
YQS
RHT
Y
A
C
W
S
L
S
AG
ANP
S
FIA
S
QM
G
HA
S
AQ
MV
F
N
V
Y
G
A
WM
T
D
S
N
A
E
Q
I
A
M
LN
QK
L
TDY
VP
M
M
P
H
fig|585397.9.peg.2160
Escherichia coli ED1a (25-423/437)
GKR
V
R
E
N
LG
VP
D
TAKN
R
KI
AGE
L
R
T
S
V
C
F
A
I
RT
G
S
FDYA
A
Q
F
P
D
S
P
NL
QA
FG
VSKK
E
I
T
V
K
E
L
EE
K
WL
D
L
K
RM
E
IS
A
N
AFN
R
Y
E
S
VA
R
---
-
--
-
-
TM
V
SK
I
G
G
SR
L
V
S
S
V
T
K
E
E
--
---
-
-
-
L
L
YI
R
K
DLL
T
G
Y
QN
S
TKNKAAAK
-
GR
S
VV
T
VN
Y
YM
T
T
I
A
G
M
FQF
A
-
A
D
H
G
Y
L
EA
N
P
FQ
G
I
KPL
K
RA
R
AE
PDP
L
TRD
E
F
I
RLID
A
C
R
H
QQ
T
K
NLW
SL
A
VY
TG
M
R
H
GEL
V
S
L
A
W
ED
ID
LK
A
GT
IT
I
RRN
Y
T
K
L
GE
FT
L
PKT
E
A
S
T
NR
VV
--
H
L
I
Q
P
A
I
S
VL
K
N
Q
AEM
TRL
G
K
Q
Y
N
I
K
V
Q
LREYGR
SVN
H
E
CT
FV
F
NPQVVRKS
E
QVG
F
VYKV
D
S
V
G
D
S
-
-
-
--
-
-
W
E
T
A
I
K
RAGI
R
HRK
A
YQS
RHT
Y
A
C
W
S
L
S
AG
ANP
S
FIA
S
QM
G
HA
S
AQ
MV
F
N
V
Y
G
A
WM
T
D
S
N
A
E
Q
I
A
M
LN
QK
L
TDY
VP
M
M
P
H
fig|344601.3.peg.3668
Escherichia coli B171 (25-423/437)
GKR
V
R
E
N
LG
VP
D
TAKN
R
KI
AGE
L
R
T
S
V
C
F
A
I
RT
G
S
FDYA
A
Q
F
P
D
S
P
NL
QA
FG
VSKK
E
I
T
V
K
E
L
EE
K
WL
D
L
K
RM
E
IS
A
N
AFN
R
Y
E
S
VA
R
---
-
--
-
-
TM
V
PK
I
G
G
SR
L
V
S
S
V
T
K
E
E
--
---
-
-
-
L
L
YI
R
K
DLL
T
G
Y
QN
S
TKNKVAAK
-
GR
S
VV
T
VN
Y
YM
T
T
I
A
G
M
FQF
A
-
A
D
H
G
Y
L
EA
N
P
FQ
G
I
KPL
K
RA
R
AE
PDP
L
TRD
E
F
I
RLID
A
C
R
H
QQ
T
K
NLW
SL
A
VY
TG
M
R
H
GEL
V
S
L
A
W
ED
ID
LK
A
GT
IT
I
RRN
Y
T
K
L
GE
FT
L
PKT
E
A
S
T
NR
VV
--
H
L
I
Q
P
A
I
S
VL
K
N
Q
AEM
TRL
G
K
Q
Y
N
I
K
V
Q
LREY
R
R
SVN
H
E
CT
FV
F
NPQVVRKS
E
QVG
F
VYKV
D
S
V
G
D
S
-
-
-
--
-
-
W
E
T
A
I
K
RAGI
R
HRK
A
YQS
RHT
Y
A
C
W
S
L
S
AG
ANP
S
FIA
S
QM
G
HA
S
AQ
MV
F
N
V
Y
G
A
WM
T
D
S
N
A
E
Q
I
A
M
LN
QK
L
TDY
VP
M
M
P
H
fig|344601.5.peg.3828
Escherichia coli B171 (25-423/437)
GKR
V
R
E
N
LG
VP
D
TAKN
R
KI
AGE
L
R
T
S
V
C
F
A
I
RT
G
S
FDYA
A
Q
F
P
D
S
P
NL
QA
FG
VSKK
E
I
T
V
K
E
L
EE
K
WL
D
L
K
RM
E
IS
A
N
AFN
R
Y
E
S
VA
R
---
-
--
-
-
TM
V
PK
I
G
G
SR
L
V
S
S
V
T
K
E
E
--
---
-
-
-
L
L
YI
R
K
DLL
T
G
Y
QN
S
TKNKVAAK
-
GR
S
VV
T
VN
Y
YM
T
T
I
A
G
M
FQF
A
-
A
D
H
G
Y
L
EA
N
P
FQ
G
I
KPL
K
RA
R
AE
PDP
L
TRD
E
F
I
RLID
A
C
R
H
QQ
T
K
NLW
SL
A
VY
TG
M
R
H
GEL
V
S
L
A
W
ED
ID
LK
A
GT
IT
I
RRN
Y
T
K
L
GE
FT
L
PKT
E
A
S
T
NR
VV
--
H
L
I
Q
P
A
I
S
VL
K
N
Q
AEM
TRL
G
K
Q
Y
N
I
K
V
Q
LREY
R
R
SVN
H
E
CT
FV
F
NPQVVRKS
E
QVG
F
VYKV
D
S
V
G
D
S
-
-
-
--
-
-
W
E
T
A
I
K
RAGI
R
HRK
A
YQS
RHT
Y
A
C
W
S
L
S
AG
ANP
S
FIA
S
QM
G
HA
S
AQ
MV
F
N
V
Y
G
A
WM
T
D
S
N
A
E
Q
I
A
M
LN
QK
L
TDY
VP
M
M
P
H
fig|6666666.5357.peg.320
Escherichia coli TY-2482 (25-422/436)
GKR
V
R
E
N
LG
VP
D
TAKN
R
KI
AGE
L
R
T
S
V
C
F
A
I
RT
G
S
FDYA
A
Q
F
P
D
S
P
NL
QA
FG
VSKK
E
I
T
V
K
E
L
EE
K
WL
D
L
K
RM
E
IS
A
N
AFN
R
Y
E
S
VA
R
---
-
--
-
-
TM
V
PK
I
G
G
SR
L
V
S
S
V
T
K
E
E
--
---
-
-
-
L
L
YI
R
K
DLL
T
G
Y
QN
S
MKNK-AAK
-
GR
S
VV
T
VN
Y
YM
T
T
I
A
G
M
FQF
A
-
A
D
H
G
Y
L
EA
N
P
FQ
G
I
KPL
K
RA
R
AE
PDP
L
TRD
E
F
I
RLID
A
C
R
H
QQ
T
K
NLW
SL
A
VY
TG
M
R
H
GEL
V
S
L
A
W
ED
ID
LK
A
GT
IT
I
RRN
Y
T
K
L
GE
FT
L
PKT
E
A
S
T
NR
VV
--
H
L
I
Q
P
A
I
S
VL
K
N
Q
AEM
TRL
G
K
Q
Y
N
I
K
V
Q
LREYGR
SVN
H
E
CT
FV
F
NPQVVRKS
E
QVG
F
VYKV
D
S
V
G
D
S
-
-
-
--
-
-
W
E
T
A
I
K
RAGI
R
HRK
A
YQS
RHT
Y
A
C
W
S
L
S
AG
ANP
S
FIA
S
QM
G
HA
S
AQ
MV
F
N
V
Y
G
A
WM
T
D
S
N
A
E
Q
I
A
M
LN
QK
L
TDY
VP
M
M
P
H
fig|562.375.peg.2078
Escherichia coli EC4100B (25-422/436)
GKR
V
R
E
N
LG
VP
D
TAKN
R
KI
AGE
L
R
T
S
V
C
F
A
I
RT
G
S
FDYA
A
Q
F
P
D
S
P
NL
QA
FG
VSKK
E
I
T
V
K
E
L
EE
K
WL
D
L
K
RM
E
IS
A
N
AFN
R
Y
E
S
VA
R
---
-
--
-
-
TM
V
PK
I
G
G
SR
L
V
S
S
V
T
K
E
E
--
---
-
-
-
L
L
YI
R
K
DLL
T
G
Y
QN
S
MKNK-AAK
-
GR
S
VV
T
VN
Y
YM
T
T
I
A
G
M
FQF
A
-
A
D
H
G
Y
L
EA
N
P
FQ
G
I
KPL
K
RA
R
AE
PDP
L
TRD
E
F
I
RLID
A
C
R
H
QQ
T
K
NLW
SL
A
VY
TG
M
R
H
GEL
V
S
L
A
W
ED
ID
LK
A
GT
IT
I
RRN
Y
T
K
L
GE
FT
L
PKT
E
A
S
T
NR
VV
--
H
L
I
Q
P
A
I
S
VL
K
N
Q
AEM
TRL
G
K
Q
Y
N
I
K
V
Q
LREYGR
SVN
H
E
CT
FV
F
NPQVVRKS
E
QVG
F
VYKV
D
S
V
G
D
S
-
-
-
--
-
-
W
E
T
A
I
K
RAGI
R
HRK
A
YQS
RHT
Y
A
C
W
S
L
S
AG
ANP
S
FIA
S
QM
G
HA
S
AQ
MV
F
N
V
Y
G
A
WM
T
D
S
N
A
E
Q
I
A
M
LN
QK
L
TDY
VP
M
M
P
H
fig|679207.4.peg.4659
Escherichia coli MS 107-1 (16-426/426)
I
W
F
VY
K
G
V
R
V
R
E
N
LG
VP
D
TAKN
R
R
V
AGE
L
R
S
S
V
C
Y
A
I
K
T
G
V
FDYA
K
Q
F
P
S
S
R
NL
EK
FG
EARQ
D
L
T
I
K
E
L
AE
KF
L
A
L
K
ET
E
VA
I
T
SL
N
T
Y
R
AV
I
K
---
-
--
-
-
NI
L
SI
I
G
E
KN
L
A
S
S
I
N
K
E
K
--
---
-
-
-
L
L
EV
R
K
ELL
T
G
Y
QI
P
KSNYIVTQ
PGR
S
AV
T
VN
N
YM
T
N
L
N
A
V
FQFG
-
V
D
N
G
Y
L
AD
N
P
FK
G
I
SPL
K
ES
R
TI
PDP
L
SRE
E
F
I
RLID
A
C
R
N
QQ
A
K
NLW
CV
SVY
TG
V
R
P
GEL
C
A
L
G
W
ED
ID
LK
N
GT
MM
I
RRN
L
A
K
-
DR
FT
V
PKT
Q
A
G
T
NR
V
I
--
H
L
I
K
P
A
I
D
A
LR
S
Q
MTL
TRL
S
K
E
H
I
I
D
V
H
LREYGR
TEK
Q
K
CT
FV
F
QPEVSARV
K
NYG
D
HFTV
D
S
I
R
Q
M
-
-
-
--
-
-
W
D
A
A
I
K
RAG
L
R
HRK
S
YQS
RHT
Y
A
C
W
S
L
T
AG
ANPAFIA
N
QM
G
HADAQ
MV
F
Q
V
Y
G
K
WM
S
E
N
N
N
AQ
V
A
L
LN
TQ
L
SEF
A
P
T
M
P
H
N
E
A
M
KN
fig|679206.4.peg.1328
Escherichia coli MS 119-7 (16-426/426)
I
W
F
VY
K
G
V
R
V
R
E
N
LG
VP
D
T
T
KN
R
R
V
AGE
L
R
S
S
V
C
Y
A
I
K
T
G
V
FDYA
K
Q
F
P
S
S
R
NL
EK
FG
EARQ
D
L
T
I
K
E
L
AE
KF
L
A
L
K
ET
E
VA
K
T
SL
N
T
Y
R
AV
I
K
---
-
--
-
-
NI
L
SI
I
G
E
KN
L
A
S
S
I
N
K
E
K
--
---
-
-
-
L
L
EV
R
K
ELL
T
G
Y
QI
P
KSNYIVTQ
PGR
S
AV
T
VN
N
YM
T
N
L
N
A
V
FQFG
-
V
D
N
G
Y
L
AD
N
P
FK
G
I
SPL
K
ES
R
TI
PDP
L
SRE
E
F
I
RLID
A
C
R
N
QQ
A
K
NLW
CV
SVY
TG
V
R
P
GEL
C
A
L
G
W
ED
ID
LK
N
GT
MM
I
RRN
L
A
K
-
DR
FT
V
PKT
Q
A
G
T
NR
V
I
--
H
L
I
K
P
A
I
D
A
LR
S
Q
MTL
TRL
S
K
E
H
I
I
D
V
H
LREYGR
TEK
Q
K
CT
FV
F
QPEVSARV
K
NYG
D
HFTV
D
S
I
R
Q
M
-
-
-
--
-
-
W
D
A
A
I
K
RAG
L
R
HRK
S
YQS
RHT
Y
A
C
W
S
L
T
AG
ANPAFIA
N
QM
G
HADAQ
MV
F
Q
V
Y
G
K
WM
S
E
N
N
N
AQ
V
A
L
LN
TQ
L
SEF
A
P
T
M
P
H
N
E
A
M
KN
fig|749532.3.peg.1345
Escherichia coli MS 78-1 (16-426/426)
I
W
F
VY
K
G
V
R
V
R
E
N
LG
VP
D
TAKN
R
R
V
AGE
L
R
A
S
V
C
Y
A
I
K
T
G
V
FDYA
K
Q
F
P
S
S
R
NL
EK
FG
ETRQ
D
L
T
I
K
E
L
AE
KF
L
A
L
K
ET
E
VA
K
T
SL
N
T
Y
R
AV
I
K
---
-
--
-
-
NI
L
SI
I
G
E
KN
L
A
S
S
I
N
K
E
K
--
---
-
-
-
L
L
EV
R
K
ELL
T
G
Y
QI
P
KSNYIVTQ
PGR
S
AV
T
VN
N
YM
T
N
L
N
A
V
FQFG
-
V
D
N
G
Y
L
AD
N
P
FK
G
I
SPL
K
ES
R
TI
PDP
L
SRE
E
F
I
RLID
A
C
R
N
QQ
A
K
NLW
CV
SVY
TG
V
R
P
GEL
C
A
L
G
W
ED
ID
LK
N
GT
MM
I
RRN
L
A
K
-
DR
FT
V
PKT
Q
A
G
T
NR
V
I
--
H
L
I
K
P
A
I
D
A
LR
S
Q
MTL
TRL
S
K
E
H
I
I
D
V
H
LREYGR
TEK
HK
CT
FV
F
QPEVSARV
K
NYG
D
HFTV
D
S
I
R
Q
M
-
-
-
--
-
-
W
D
A
A
I
K
RAG
L
R
HRK
S
YQS
RHT
Y
A
C
W
S
L
T
AG
ANPAFIA
N
QM
G
HADAQ
MV
F
Q
V
Y
G
K
WM
S
E
N
N
N
AQ
V
A
L
LN
TQ
L
SEF
A
P
T
M
P
H
N
E
A
M
KN
fig|340184.3.peg.1023
Escherichia coli B7A (21-431/431)
I
W
F
VY
K
G
V
R
V
R
E
N
LG
VP
D
TAKN
R
R
V
AGE
L
R
S
S
V
C
Y
A
I
K
T
G
V
FDYA
K
Q
F
P
S
S
R
NL
EK
FG
EARQ
D
L
T
I
K
E
L
AE
KF
L
A
L
K
ET
E
VA
K
T
SL
N
T
Y
R
AV
I
K
---
-
--
-
-
NI
L
SI
I
G
E
KN
L
A
S
S
I
N
K
E
K
--
---
-
-
-
L
L
EV
R
K
ELL
T
G
Y
QI
P
KSNYIVTQ
PGR
S
AV
T
VN
N
YM
T
N
L
N
A
V
FQFG
-
V
D
N
G
Y
L
AD
N
P
FK
G
I
SPL
K
ES
R
TI
PDP
L
SRE
E
F
I
RLID
A
C
R
N
QQ
A
K
NLW
CV
SVY
TG
V
R
P
GEL
C
A
L
G
W
ED
ID
LK
N
GT
MM
I
RRN
L
A
K
-
DR
FT
V
PKT
Q
A
G
T
NR
V
I
--
H
L
I
K
P
A
I
D
A
LR
S
Q
MTL
TRL
S
K
E
H
I
I
D
V
H
LREYGR
TEK
HK
CT
FV
F
QPEVSARV
K
NYG
D
HFTV
D
S
I
R
Q
M
-
-
-
--
-
-
W
D
A
A
I
K
RAG
L
R
HRK
S
YQS
RHT
Y
A
C
W
S
L
T
AG
ANPAFIA
N
QM
G
HADAQ
MV
F
Q
V
Y
G
K
WM
S
E
N
N
N
AQ
V
A
L
LN
TQ
L
SEF
A
P
T
M
P
H
N
E
A
M
KN
fig|340184.6.peg.1058
Escherichia coli B7A (16-426/426)
I
W
F
VY
K
G
V
R
V
R
E
N
LG
VP
D
TAKN
R
R
V
AGE
L
R
S
S
V
C
Y
A
I
K
T
G
V
FDYA
K
Q
F
P
S
S
R
NL
EK
FG
EARQ
D
L
T
I
K
E
L
AE
KF
L
A
L
K
ET
E
VA
K
T
SL
N
T
Y
R
AV
I
K
---
-
--
-
-
NI
L
SI
I
G
E
KN
L
A
S
S
I
N
K
E
K
--
---
-
-
-
L
L
EV
R
K
ELL
T
G
Y
QI
P
KSNYIVTQ
PGR
S
AV
T
VN
N
YM
T
N
L
N
A
V
FQFG
-
V
D
N
G
Y
L
AD
N
P
FK
G
I
SPL
K
ES
R
TI
PDP
L
SRE
E
F
I
RLID
A
C
R
N
QQ
A
K
NLW
CV
SVY
TG
V
R
P
GEL
C
A
L
G
W
ED
ID
LK
N
GT
MM
I
RRN
L
A
K
-
DR
FT
V
PKT
Q
A
G
T
NR
V
I
--
H
L
I
K
P
A
I
D
A
LR
S
Q
MTL
TRL
S
K
E
H
I
I
D
V
H
LREYGR
TEK
HK
CT
FV
F
QPEVSARV
K
NYG
D
HFTV
D
S
I
R
Q
M
-
-
-
--
-
-
W
D
A
A
I
K
RAG
L
R
HRK
S
YQS
RHT
Y
A
C
W
S
L
T
AG
ANPAFIA
N
QM
G
HADAQ
MV
F
Q
V
Y
G
K
WM
S
E
N
N
N
AQ
V
A
L
LN
TQ
L
SEF
A
P
T
M
P
H
N
E
A
M
KN
fig|656393.3.peg.2365
Escherichia coli H299 (16-426/426)
I
W
F
VY
K
G
V
R
V
R
E
N
LG
VP
D
TAKN
R
R
V
AGE
L
R
A
S
V
C
Y
A
I
K
T
G
V
FDYA
K
Q
F
P
S
S
R
NL
EK
FG
EARQ
D
L
T
I
K
E
L
AE
KF
L
A
L
K
ET
E
VA
K
T
SL
N
T
Y
R
AV
I
K
---
-
--
-
-
NI
L
SI
I
G
E
KN
L
A
S
S
I
N
K
E
K
--
---
-
-
-
L
L
EV
R
K
ELL
T
G
Y
QI
P
KSNYIVTQ
PGR
S
AV
T
VN
N
YM
T
N
L
N
A
V
FQFG
-
V
D
N
G
Y
L
AD
N
P
FK
G
I
SPL
K
ES
R
TI
PDP
L
SRE
E
F
I
RLID
A
C
R
N
QQ
A
K
NLW
CV
SVY
TG
V
R
P
GEL
C
A
L
G
W
ED
ID
LK
N
GT
MM
I
RRN
L
A
K
-
DR
FT
V
PKT
Q
A
G
T
NR
V
I
--
H
L
I
K
P
A
I
D
A
LR
S
Q
MTL
TRL
S
K
E
H
I
I
D
V
Y
LREYGR
TEK
HK
CT
FV
F
QPEVSARV
K
NYG
D
HFTV
D
S
I
R
Q
M
-
-
-
--
-
-
W
D
A
A
I
K
RAG
L
R
HRK
S
YQS
RHT
Y
A
C
W
S
L
T
AG
ANPAFIA
N
QM
G
HADAQ
MV
F
Q
V
Y
G
K
WM
S
E
N
N
N
AQ
V
A
L
LN
TQ
L
SEF
A
P
T
M
P
H
N
E
A
M
KN
fig|585034.4.peg.1613
Escherichia coli IAI1 (16-426/426)
I
W
F
VY
K
G
V
R
V
R
E
N
LG
VP
D
TAKN
R
R
V
AGE
L
R
S
S
V
C
Y
A
I
K
T
G
V
FDYA
K
Q
F
P
S
S
R
NL
EK
FG
EARQ
D
L
T
I
K
E
L
AE
KF
L
A
L
K
ET
E
VA
K
T
SL
N
T
Y
R
AV
I
K
---
-
--
-
-
NI
L
SI
I
G
E
KN
L
A
S
S
I
N
K
E
K
--
---
-
-
-
L
L
EV
R
K
ELL
T
G
Y
QI
P
KSNYIVTQ
PGR
S
AV
T
VN
N
YM
T
N
L
N
A
V
FQFG
-
V
D
N
G
Y
L
AD
N
P
FK
G
I
SPL
K
ES
R
TI
P
E
P
L
SRE
E
F
I
RLID
A
C
R
N
QQ
A
K
NLW
CV
SVY
TG
V
R
P
GEL
C
A
L
G
W
ED
ID
LK
N
GT
MM
I
RRN
L
A
K
-
DR
FT
V
PKT
Q
A
G
T
NR
V
I
--
H
L
I
K
P
A
I
D
A
LR
S
Q
MTL
TRL
S
K
E
H
I
I
D
V
H
LREYGR
TEK
Q
K
CT
FV
F
QPEVSARV
K
NYG
D
HFTV
D
S
I
R
Q
M
-
-
-
--
-
-
W
D
A
A
I
K
RAG
L
R
HRK
S
YQS
RHT
Y
A
C
W
S
L
T
AG
ANPAFIA
N
QM
G
HADAQ
MV
F
Q
V
Y
G
K
WM
S
E
N
N
N
AQ
V
A
L
LN
TQ
L
SEF
A
P
T
M
P
H
N
E
A
M
KN
fig|585034.5.peg.1608
Escherichia coli IAI1 (16-426/426)
I
W
F
VY
K
G
V
R
V
R
E
N
LG
VP
D
TAKN
R
R
V
AGE
L
R
S
S
V
C
Y
A
I
K
T
G
V
FDYA
K
Q
F
P
S
S
R
NL
EK
FG
EARQ
D
L
T
I
K
E
L
AE
KF
L
A
L
K
ET
E
VA
K
T
SL
N
T
Y
R
AV
I
K
---
-
--
-
-
NI
L
SI
I
G
E
KN
L
A
S
S
I
N
K
E
K
--
---
-
-
-
L
L
EV
R
K
ELL
T
G
Y
QI
P
KSNYIVTQ
PGR
S
AV
T
VN
N
YM
T
N
L
N
A
V
FQFG
-
V
D
N
G
Y
L
AD
N
P
FK
G
I
SPL
K
ES
R
TI
P
E
P
L
SRE
E
F
I
RLID
A
C
R
N
QQ
A
K
NLW
CV
SVY
TG
V
R
P
GEL
C
A
L
G
W
ED
ID
LK
N
GT
MM
I
RRN
L
A
K
-
DR
FT
V
PKT
Q
A
G
T
NR
V
I
--
H
L
I
K
P
A
I
D
A
LR
S
Q
MTL
TRL
S
K
E
H
I
I
D
V
H
LREYGR
TEK
Q
K
CT
FV
F
QPEVSARV
K
NYG
D
HFTV
D
S
I
R
Q
M
-
-
-
--
-
-
W
D
A
A
I
K
RAG
L
R
HRK
S
YQS
RHT
Y
A
C
W
S
L
T
AG
ANPAFIA
N
QM
G
HADAQ
MV
F
Q
V
Y
G
K
WM
S
E
N
N
N
AQ
V
A
L
LN
TQ
L
SEF
A
P
T
M
P
H
N
E
A
M
KN
fig|331111.12.peg.2073
Escherichia coli E24377A (16-426/426)
I
W
F
VY
K
G
V
R
V
R
E
N
LG
VP
D
TAKN
R
R
V
AGE
L
R
A
S
V
C
Y
A
I
K
T
G
V
FDYA
K
Q
F
P
S
S
R
NL
EK
FG
EARQ
D
L
T
I
K
E
L
AE
KF
L
A
L
K
ET
E
VA
K
T
SL
N
T
Y
R
AV
I
K
---
-
--
-
-
NI
L
SI
I
G
E
KN
L
A
S
S
I
N
K
E
K
--
---
-
-
-
L
L
EV
R
K
ELL
T
G
Y
QI
P
KSNYIVTQ
PGR
S
AV
T
VN
N
YM
T
N
L
N
A
V
FQFG
-
V
D
N
G
Y
L
AD
N
P
FK
G
I
SPL
K
ES
R
TI
PDP
L
SRE
E
F
I
RLID
A
C
R
N
QQ
A
K
NLW
CV
SVY
TG
V
R
P
GEL
C
A
L
G
W
ED
ID
LK
N
GT
MM
I
RRN
L
A
K
-
DR
FT
V
PKT
Q
A
G
T
NR
V
I
--
H
L
I
K
P
A
I
D
A
LR
S
Q
MTL
TRL
S
K
E
H
I
I
D
V
H
LREYGR
TEK
Q
K
CT
FV
F
QPEVSARV
K
NYG
D
HFTV
D
S
I
R
Q
M
-
-
-
--
-
-
W
D
A
A
I
K
RAG
L
R
HRK
S
YQS
RHT
Y
A
C
W
S
L
T
AG
ANPAFIA
N
QM
G
HADAQ
MV
F
K
V
Y
G
K
WM
S
E
N
N
N
AQ
V
A
L
LN
TQ
L
SEF
A
P
T
M
P
H
N
E
A
M
KN
fig|331111.3.peg.4216
Escherichia coli E24377A (21-431/431)
I
W
F
VY
K
G
V
R
V
R
E
N
LG
VP
D
TAKN
R
R
V
AGE
L
R
A
S
V
C
Y
A
I
K
T
G
V
FDYA
K
Q
F
P
S
S
R
NL
EK
FG
EARQ
D
L
T
I
K
E
L
AE
KF
L
A
L
K
ET
E
VA
K
T
SL
N
T
Y
R
AV
I
K
---
-
--
-
-
NI
L
SI
I
G
E
KN
L
A
S
S
I
N
K
E
K
--
---
-
-
-
L
L
EV
R
K
ELL
T
G
Y
QI
P
KSNYIVTQ
PGR
S
AV
T
VN
N
YM
T
N
L
N
A
V
FQFG
-
V
D
N
G
Y
L
AD
N
P
FK
G
I
SPL
K
ES
R
TI
PDP
L
SRE
E
F
I
RLID
A
C
R
N
QQ
A
K
NLW
CV
SVY
TG
V
R
P
GEL
C
A
L
G
W
ED
ID
LK
N
GT
MM
I
RRN
L
A
K
-
DR
FT
V
PKT
Q
A
G
T
NR
V
I
--
H
L
I
K
P
A
I
D
A
LR
S
Q
MTL
TRL
S
K
E
H
I
I
D
V
H
LREYGR
TEK
Q
K
CT
FV
F
QPEVSARV
K
NYG
D
HFTV
D
S
I
R
Q
M
-
-
-
--
-
-
W
D
A
A
I
K
RAG
L
R
HRK
S
YQS
RHT
Y
A
C
W
S
L
T
AG
ANPAFIA
N
QM
G
HADAQ
MV
F
K
V
Y
G
K
WM
S
E
N
N
N
AQ
V
A
L
LN
TQ
L
SEF
A
P
T
M
P
H
N
E
A
M
KN
fig|679205.4.peg.1607
Escherichia coli MS 124-1 (16-426/426)
I
W
F
VY
K
G
V
R
V
R
E
N
LG
VP
D
TAKN
R
R
V
AGE
L
R
A
S
V
C
Y
A
I
K
T
G
V
FDYA
K
Q
F
P
S
S
R
NL
EK
FG
EARQ
D
L
T
I
K
E
L
AE
KF
L
A
L
K
ET
E
VA
K
T
SL
N
T
Y
R
AV
I
K
---
-
--
-
-
NI
L
SI
I
G
E
KN
L
A
S
S
I
N
K
E
K
--
---
-
-
-
L
L
EV
R
K
ELL
T
G
Y
QI
P
KSNYIVTQ
PGR
S
AV
T
VN
N
YM
T
N
L
N
A
V
FQFG
-
V
D
N
G
Y
L
AD
N
P
FK
G
I
SPL
K
ES
R
TI
PDP
L
SRE
E
F
I
RLID
A
C
R
N
QQ
A
K
NLW
CV
SVY
TG
V
R
P
GEL
C
A
L
G
W
ED
ID
LK
N
GT
MM
I
RRN
L
A
K
-
DR
FT
V
PKT
Q
A
G
T
NR
V
I
--
H
L
I
K
P
A
I
D
A
LR
S
Q
MTL
TRL
S
K
E
H
I
I
D
V
H
LREYGR
TEK
Q
K
CT
FV
F
QPEVSARV
K
NYG
D
HFTV
D
S
I
R
Q
M
-
-
-
--
-
-
W
D
A
A
I
K
RAG
L
R
HRK
S
YQS
RHT
Y
A
C
W
S
L
T
AG
ANPAFIA
N
QM
G
HADAQ
MV
F
K
V
Y
G
K
WM
S
E
N
N
N
AQ
V
A
L
LN
TQ
L
SEF
A
P
T
M
P
H
N
E
A
M
KN
fig|749533.3.peg.4949
Escherichia coli MS 84-1 (16-426/426)
I
W
F
VY
K
G
V
R
V
R
E
N
LG
VP
D
TAKN
R
R
V
AGE
L
R
A
S
V
C
Y
A
I
K
T
G
V
FDYA
K
Q
F
P
S
S
R
NL
EK
FG
EARQ
D
L
T
I
K
E
L
AE
KF
L
A
L
K
ET
E
VA
K
T
SL
N
T
Y
R
AV
I
K
---
-
--
-
-
NI
L
SI
I
G
E
KN
L
A
S
S
I
N
K
E
K
--
---
-
-
-
L
L
EV
R
K
ELL
T
G
Y
QI
P
KSNYIVTQ
PGR
S
AV
T
VN
N
YM
T
N
L
N
A
V
FQFG
-
V
D
N
G
Y
L
AD
N
P
FK
G
I
SPL
K
ES
R
TI
PDP
L
SRE
E
F
I
RLID
A
C
R
N
QQ
A
K
NLW
CV
SVY
TG
V
R
P
GEL
C
A
L
G
W
ED
ID
LK
N
GT
MM
I
RRN
L
A
K
-
DR
FT
V
PKT
Q
A
G
T
NR
V
I
--
H
L
I
K
P
A
I
D
A
LR
S
Q
MTL
TRL
S
K
E
H
I
I
D
V
H
LREYGR
TEK
Q
K
CT
FV
F
QPEVSARV
K
NYG
D
HFTV
D
S
I
R
Q
M
-
-
-
--
-
-
W
D
A
A
I
K
RAG
L
R
HRK
S
YQS
RHT
Y
A
C
W
S
L
T
AG
ANPAFIA
N
QM
G
HADAQ
MV
F
K
V
Y
G
K
WM
S
E
N
N
N
AQ
V
A
L
LN
TQ
L
SEF
A
P
T
M
P
H
N
E
A
M
KN
fig|585396.4.peg.2127
Escherichia coli O111:H- str. 11128 (16-426/426)
I
W
F
VY
K
G
V
R
V
R
E
N
LG
VP
D
TAKN
R
R
V
AGE
L
R
S
S
V
C
Y
A
I
K
T
G
V
FDYA
K
Q
F
P
S
S
R
NL
EK
FG
EARQ
D
L
T
I
K
E
L
AE
KF
L
A
L
K
EN
E
VA
K
T
SL
N
T
Y
R
AV
I
K
---
-
--
-
-
NI
L
SI
I
G
E
KN
L
A
S
S
I
N
K
E
K
--
---
-
-
-
L
L
EV
R
K
ELL
T
G
Y
QI
P
KSNYIVTQ
PGR
S
AV
T
VN
N
YM
T
N
L
N
A
V
FQFG
-
V
D
N
G
Y
L
AD
N
P
FK
G
I
SPL
K
ES
R
TI
PDP
L
SRE
E
F
I
RLID
A
C
R
N
QQ
A
K
NLW
CV
SVY
TG
V
R
P
GEL
C
A
L
G
W
ED
ID
LK
N
GT
MM
I
RRN
L
A
K
-
DR
FT
V
PKT
Q
A
G
T
NR
V
I
--
H
L
I
K
P
A
I
D
A
LR
S
Q
MTL
TRL
S
K
E
H
I
I
D
V
H
L
K
EYGR
TEK
Q
K
CT
FV
F
QPEVSARV
K
NYG
D
HFTV
D
S
I
R
Q
M
-
-
-
--
-
-
W
D
A
A
I
K
RAG
L
R
HRK
S
YQS
RHT
Y
A
C
W
S
L
T
AG
ANPAFIA
N
QM
G
HADAQ
MV
F
Q
V
Y
G
K
WM
S
E
N
N
N
AQ
V
A
L
LN
TQ
L
SEF
A
P
T
M
P
H
N
E
A
I
KN
fig|585055.6.peg.1772
Escherichia coli 55989 (16-426/426)
I
W
F
VY
K
G
V
R
V
R
E
N
LG
VP
D
TAKN
R
R
V
AGE
L
R
A
S
V
C
Y
A
I
K
T
G
V
FDYA
K
Q
F
P
S
S
R
NL
EK
FG
EARQ
D
L
T
I
K
E
L
AE
KF
L
A
L
K
ET
E
VA
K
T
SL
N
T
Y
R
AV
I
K
---
-
--
-
-
NI
L
SI
I
G
E
KN
L
A
S
S
I
N
K
E
K
--
---
-
-
-
L
L
EV
R
K
ELL
T
G
Y
QI
P
KSNYIVTQ
PGR
S
AV
T
VN
N
YM
T
N
L
N
A
V
FQFG
-
V
D
N
G
Y
L
AD
N
P
FK
G
I
SPL
K
ES
R
TI
PDP
L
SRE
E
F
I
RLID
A
C
R
N
QQ
A
K
NLW
CV
SVY
TG
V
R
P
GEL
C
A
L
G
W
ED
ID
LK
N
GT
MM
I
RRN
L
A
K
-
DR
FT
V
PKT
Q
A
G
T
NR
V
I
--
H
L
I
K
P
A
I
D
A
LR
S
Q
MTL
TRL
S
K
E
H
I
I
D
V
H
LREYGR
TEK
Q
K
CT
FV
F
QPEVSARV
K
NYG
D
HFTV
D
S
I
R
Q
M
-
-
-
--
-
-
W
D
A
A
I
K
RAG
L
R
HRK
S
YQS
RHT
Y
A
C
W
S
L
T
AG
ANPAFIA
N
QM
G
HADAQ
MV
F
Q
V
Y
G
K
WM
S
E
N
N
N
AQ
V
A
L
LN
TQ
L
SEF
A
P
T
M
P
H
N
E
A
M
KN
fig|585055.8.peg.1776
Escherichia coli 55989 (16-426/426)
I
W
F
VY
K
G
V
R
V
R
E
N
LG
VP
D
TAKN
R
R
V
AGE
L
R
A
S
V
C
Y
A
I
K
T
G
V
FDYA
K
Q
F
P
S
S
R
NL
EK
FG
EARQ
D
L
T
I
K
E
L
AE
KF
L
A
L
K
ET
E
VA
K
T
SL
N
T
Y
R
AV
I
K
---
-
--
-
-
NI
L
SI
I
G
E
KN
L
A
S
S
I
N
K
E
K
--
---
-
-
-
L
L
EV
R
K
ELL
T
G
Y
QI
P
KSNYIVTQ
PGR
S
AV
T
VN
N
YM
T
N
L
N
A
V
FQFG
-
V
D
N
G
Y
L
AD
N
P
FK
G
I
SPL
K
ES
R
TI
PDP
L
SRE
E
F
I
RLID
A
C
R
N
QQ
A
K
NLW
CV
SVY
TG
V
R
P
GEL
C
A
L
G
W
ED
ID
LK
N
GT
MM
I
RRN
L
A
K
-
DR
FT
V
PKT
Q
A
G
T
NR
V
I
--
H
L
I
K
P
A
I
D
A
LR
S
Q
MTL
TRL
S
K
E
H
I
I
D
V
H
LREYGR
TEK
Q
K
CT
FV
F
QPEVSARV
K
NYG
D
HFTV
D
S
I
R
Q
M
-
-
-
--
-
-
W
D
A
A
I
K
RAG
L
R
HRK
S
YQS
RHT
Y
A
C
W
S
L
T
AG
ANPAFIA
N
QM
G
HADAQ
MV
F
Q
V
Y
G
K
WM
S
E
N
N
N
AQ
V
A
L
LN
TQ
L
SEF
A
P
T
M
P
H
N
E
A
M
KN
fig|562.375.peg.1676
Escherichia coli EC4100B (16-426/426)
I
W
F
VY
K
G
V
R
V
R
E
N
LG
VP
D
TAKN
R
R
V
AGE
L
R
A
S
V
C
Y
A
I
K
T
G
V
FDYA
K
Q
F
P
S
S
R
NL
EK
FG
EARQ
D
L
T
I
K
E
L
AE
KF
L
A
L
K
ET
E
VA
K
T
SL
N
T
Y
R
AV
I
K
---
-
--
-
-
NI
L
SI
I
G
E
KN
L
A
S
S
I
N
K
E
K
--
---
-
-
-
L
L
EV
R
K
ELL
T
G
Y
QI
P
KSNYIVTQ
PGR
S
AV
T
VN
N
YM
T
N
L
N
A
V
FQFG
-
V
D
N
G
Y
L
AD
N
P
FK
G
I
SPL
K
ES
R
TI
PDP
L
SRE
E
F
I
RLID
A
C
R
N
QQ
A
K
NLW
CV
SVY
TG
V
R
P
GEL
C
A
L
G
W
ED
ID
LK
N
GT
MM
I
RRN
L
A
K
-
DR
FT
V
PKT
Q
A
G
T
NR
V
I
--
H
L
I
K
P
A
I
D
A
LR
S
Q
MTL
TRL
S
K
E
H
I
I
D
V
H
LREYGR
TEK
Q
K
CT
FV
F
QPEVSARV
K
NYG
D
HFTV
D
S
I
R
Q
M
-
-
-
--
-
-
W
D
A
A
I
K
RAG
L
R
HRK
S
YQS
RHT
Y
A
C
W
S
L
T
AG
ANPAFIA
N
QM
G
HADAQ
MV
F
Q
V
Y
G
K
WM
S
E
N
N
N
AQ
V
A
L
LN
TQ
L
SEF
A
P
T
M
P
H
N
E
A
M
KN
fig|685038.3.peg.1594
Escherichia coli O83:H1 str. NRG 857C (16-426/426)
I
W
F
VY
K
G
V
R
V
R
E
N
LG
VP
D
TAKN
R
R
V
AGE
L
R
A
S
V
C
Y
A
I
K
T
G
V
FDYA
K
Q
F
P
S
S
R
NL
EK
FG
EARQ
D
L
T
I
K
E
L
AE
KF
L
A
L
K
ET
E
VA
K
T
SL
N
T
Y
R
AV
I
K
---
-
--
-
-
NI
L
SI
I
G
E
KN
L
A
S
S
I
N
K
E
K
--
---
-
-
-
L
L
EV
R
K
ELL
T
G
Y
QI
P
KSNYIVTQ
PGR
S
AV
T
VN
N
YM
T
N
L
N
A
V
FQFG
-
V
D
N
G
Y
L
PD
N
P
FK
G
I
SPL
K
ES
R
TI
PDP
L
SRE
E
F
I
RLID
A
C
R
N
QQ
A
K
NLW
CV
SVY
TG
V
R
P
GEL
C
A
L
G
W
ED
ID
LK
N
GT
MM
I
RRN
L
A
K
-
DR
FT
V
PKT
Q
A
G
T
NR
V
I
--
H
L
I
K
P
A
I
D
A
LR
S
Q
MTL
TRL
S
K
E
H
I
I
D
V
H
LREYGR
TEK
Q
K
CT
FV
F
QPEVSARV
K
NYG
D
HFTV
D
S
I
R
Q
M
-
-
-
--
-
-
W
D
A
A
I
K
RAG
L
R
HRK
S
YQS
RHT
Y
A
C
W
S
L
T
AG
ANPAFIA
N
QM
G
HADAQ
MV
F
Q
V
Y
G
K
WM
S
E
N
N
N
AQ
V
A
L
LN
TQ
L
SEF
A
P
T
M
P
H
N
E
A
M
KN
fig|656444.3.peg.2466
Escherichia coli TA280 (16-426/426)
I
W
F
VY
K
G
V
R
V
R
E
N
LG
VP
D
TAKN
R
R
V
AGE
L
R
S
S
V
C
Y
A
I
K
T
G
V
FDYA
K
Q
F
P
S
S
R
NL
EK
FG
EARQ
D
L
T
I
K
E
L
AE
KF
L
A
L
K
ET
E
VA
K
T
SL
N
T
Y
R
AV
I
K
---
-
--
-
-
NI
L
SI
I
G
E
KN
L
A
S
S
I
N
K
E
K
--
---
-
-
-
L
L
EV
R
K
ELL
T
G
Y
QI
P
KSNYIVTQ
PGR
S
AV
T
VN
N
YM
T
N
L
N
A
V
FQFG
-
V
D
N
G
Y
L
PD
N
P
FK
G
I
SPL
K
ES
R
TI
PDP
L
SRE
E
F
I
RLID
A
C
R
N
QQ
A
K
NLW
CV
SVY
TG
V
R
P
GEL
C
A
L
G
W
ED
ID
LK
N
GT
MM
I
RRN
L
A
K
-
DR
FT
V
PKT
Q
A
G
T
NR
V
I
--
H
L
I
K
P
A
I
D
A
LR
S
Q
MTL
TRL
S
K
E
H
I
I
D
V
H
LREYGR
TEK
Q
K
CT
FV
F
QPEVSARV
K
NYG
D
HFTV
D
S
I
R
Q
M
-
-
-
--
-
-
W
D
A
A
I
K
RAG
L
R
HRK
S
YQS
RHT
Y
A
C
W
S
L
T
AG
ANPAFIA
N
QM
G
HADAQ
MV
F
Q
V
Y
G
K
WM
S
E
N
N
N
AQ
V
A
L
LN
TQ
L
SEF
A
P
T
M
P
H
N
E
A
M
KN
fig|749531.3.peg.4795
Escherichia coli MS 69-1 (16-426/426)
I
W
F
VY
K
G
V
R
V
R
E
N
LG
VP
D
TAKN
R
R
V
AGE
L
R
S
S
V
C
Y
A
I
K
T
G
V
FDYA
K
Q
F
P
S
S
R
NL
EK
FG
EARQ
D
L
T
I
K
E
L
AE
KF
L
A
L
K
ET
E
VA
K
T
SL
N
T
Y
R
AV
I
K
---
-
--
-
-
NI
L
SI
I
G
E
KN
L
A
S
S
I
N
K
E
K
--
---
-
-
-
L
L
EV
R
K
ELL
T
G
Y
QI
P
KSNYIVTQ
PGR
S
AV
T
VN
N
YM
T
N
L
N
A
V
FQFG
-
V
D
N
G
Y
L
AD
N
P
FK
G
I
SPL
K
ES
R
TI
PDP
L
SRE
E
F
I
RLID
A
C
R
N
QQ
A
K
NLW
CV
SVY
TG
V
R
P
GEL
C
A
L
G
W
ED
ID
LK
N
GT
MM
I
RRN
L
A
K
-
DR
FT
V
PKT
Q
A
G
T
NR
V
I
--
H
L
I
K
P
A
I
D
A
LR
S
Q
MTL
TRL
S
K
E
H
I
I
D
V
H
LREYGR
TEK
Q
K
CT
FV
F
QPEVSARV
K
NYG
D
HFTV
D
S
I
R
Q
M
-
-
-
--
-
-
W
D
A
A
I
K
RAG
L
R
HRK
S
YQS
RHT
Y
A
C
W
S
L
T
AG
ANPAFIA
N
QM
G
HADAQ
MV
F
Q
V
Y
G
K
WM
S
E
N
N
N
AQ
V
A
L
LN
TQ
L
SEF
A
P
T
I
P
H
N
E
A
M
KN
fig|656419.3.peg.2273
Escherichia coli M718 (16-426/426)
I
W
F
VY
K
G
V
R
V
R
E
N
LG
VP
D
TAKN
R
R
V
AGE
L
R
S
S
V
C
Y
A
I
K
T
G
V
FDYA
K
Q
F
P
S
S
R
NL
EK
FG
EARQ
D
L
T
I
K
E
L
AE
KF
L
A
L
K
ET
E
VA
K
T
SL
N
T
Y
R
AV
I
K
---
-
--
-
-
NI
L
SI
I
G
E
KN
L
A
S
S
I
N
K
E
K
--
---
-
-
-
L
L
EV
R
K
ELL
T
G
Y
QI
P
KSNYIVTQ
PGR
S
AV
T
VN
N
YM
T
N
L
N
A
V
FQFG
-
V
D
N
G
Y
L
AD
N
P
FK
G
I
SPL
K
ES
R
TI
PDP
I
SRE
E
F
I
RLID
A
C
R
N
QQ
A
K
NLW
CV
SVY
TG
I
R
P
GEL
C
A
L
G
W
ED
ID
LK
N
GT
MM
I
RRN
L
A
K
-
DR
FT
V
PKT
Q
A
G
T
NR
V
I
--
H
L
I
K
P
A
I
D
A
LR
S
Q
MTL
TRL
S
K
E
H
I
I
D
V
H
LREYGR
TEK
Q
K
CT
FV
F
QPEVSARV
K
NYG
D
HFTV
D
S
I
R
Q
M
-
-
-
--
-
-
W
D
A
A
I
K
RAG
L
R
HRK
S
YQS
RHT
Y
A
C
W
S
L
T
AG
ANPAFIA
N
QM
G
HADAQ
MV
F
Q
V
Y
G
K
WM
S
E
N
N
N
AQ
V
A
L
LN
TQ
L
SEF
A
P
T
M
P
H
N
E
A
M
KN
Consen1
Primary consensus
MSLFRRnEIWYAsy
lp
GkR
kesLGtkDkrqa
elhdklkae
w
v
klG
----
d
P
-
--
--
dvT
eEa
rwL
eK
-
k
sld
dksri
fwl
hf
g
l
I
e
i
Sav
km
nr
e
wkl
qa
kGk
p
---
S
Tka
hla
i
ailraae
d
k
L
aP
ki
k
R
-
rwL
Ea
RLIDeC
-
ep
Ksvv
alaTGlR
sni
nL
WqqIDmq
rv
inpe
sK
-
--
---
-
sNRaigvaLndtAc
vLr
Q
---
-
-
-
-
------
hkwvFVh
-
d
pavr
mr
d
t
W
sA
rRAGi
dfr
hdlRHTwAsWli
aGvplsvlq
mgGwesieMV
-
rYa
la
nhl
eh
r
id
l
vP
msh
eiMedIKKA
Consen2
Secondary consensus
g
i
vy
v
rqn
vp
takn
agerr
s
c
a
rt
fdya
s
nl
fg
e
k
l
kf
l
e
a
afn
y
ava
---
--
-
v
g
l
s
re
--
-
-
lq
k
t
y
s
pgr
vn
ym
l
g
fqfg
-
e
g
n
gv
r
pdp
f
a
r
qq
nlw
svy
gel
ed
lk
gt
vrrn
l
ft
pkt
a
t
vv
--
h
i
p
i
a
k
trl
k
h
i
v
lreygr
q
ct
k
f
d
ig
s
-
-
-
k
l
hrk
yqs
y
c
s
s
anpafia
qm
hadaq
f
v
g
wm
n
aq
a
ln
f
a
lpq
ga
kn
Consensus 1
(when a gap)
Conservative difference
Consensus 2
(when a gap)
Nonconservative diff.
Other character