┌─ Escherichia coli (433-652/904) B354   
                                                                   ┌┴─ Escherichia coli (433-652/904) TA280   
                                                                  ┌┴┬─ Escherichia coli (433-646/676) FVEC1302   
                                                                 ┌┤ └─ Escherichia coli (433-652/900) FVEC1412 (3)  
                                                                 │└─ Escherichia coli (483-702/954) 042 (1)  
                                                                ┌┤┌─ Escherichia coli (433-652/900) APEC O1 (6)  
                                                                │└┤ ┌─ Escherichia coli (433-652/900) 2362-75 (17)  
                                                                │ └┬┴─ Escherichia coli (443-662/910) E2348/69 (1)  
                                                               ┌┤  └┬─ Escherichia coli (433-652/900) M605   
                                                               ││   └─ Escherichia coli (433-652/900) SE15   
                                                              ┌┤└─ Escherichia coli (433-646/904) H299   
                                                              │└┬─ fig|1040638.4.peg.4601 O104:H4 (433-652/904) str. LB226692 (3)  
                                                             ┌┤ └┬─ Escherichia coli (433-652/904) K12 (49)  
                                                             ││  └─ Escherichia coli (433-652/904) MS 116-1 (1)  
                                                             │└┬─ Escherichia coli (433-652/904) MS 69-1   
                                                            ┌┤ └┬─ Escherichia coli (433-652/904) B185   
                                                            ││  └┬─ Escherichia coli (433-652/904) O157:H7 str. EC869 (2)  
                                                            ││   └─ Escherichia coli (433-652/904) 1044A (22)  
                                                           ┌┤└┬─ Escherichia coli (433-652/904) IAI39 (1)  
                                                           ││ └─ Escherichia coli (433-652/900) SMS-3-5   
                                      ┌────────────────────┤└┬─ Escherichia coli (433-652/904) MS 21-1   
                                      │                    │ └─ Escherichia coli (433-652/904) B171 (4)  
                                 ┌────┤                    └─ Escherichia coli (433-652/904) M718   
                                 │    │                   ┌─ Escherichia coli (459-691/949) MS 69-1 (1)  
                                 │    └───────────────────┤┌─ Escherichia coli (459-691/949) E24377A (1)  
                                 │                        └┤ ┌─ Escherichia coli (436-668/926) SMS-3-5   
                           ┌─────┤                         └┬┴─ Escherichia coli (459-691/949) MS 21-1   
                           │     │                          └┬─ Escherichia coli (459-691/949) 1044A (25)  
                           │     │                           └─ Escherichia coli (443-675/933) K12 (99)  
                           │     └──────────────┬─ Escherichia coli (293-514/918) MS 21-1   
                    ┌──────┤                    └┬─ Escherichia coli (293-514/918) APEC O1 (13)  
                    │      │                     └─ Escherichia coli (293-514/918) K12 (114)  
                    │      │               ┌─ Escherichia coli (283-502/777) O157:H7 str. EC4024   
                    │      └───────────────┤┌─ Escherichia coli (283-502/778) MS 175-1   
                    │                      └┤ ┌─ Escherichia coli (283-502/778) 042 (1)  
                    │                       │┌┴─ Escherichia coli (283-502/778) TA143   
                    │                       └┤┌─ Escherichia coli (283-502/778) MS 69-1   
                    │                        └┤ ┌─ Escherichia coli (283-502/778) O103:H2 str. 12009   
       ┌────────────┤                         │┌┴─ Escherichia coli (283-502/778) WV_060327   
       │            │                         └┤ ┌─ fig|1040638.4.peg.1797 O104:H4 (283-502/778) str. LB226692 (116)  
       │            │                          └┬┴─ Escherichia coli (283-502/778) TA206   
       │            │                           └┬─ Escherichia coli (283-500/776) K12   
       │            │                            └┬─ Escherichia coli (283-502/778) ED1a (1)  
       │            │                             └─ Escherichia coli (283-502/778) HS (1)  
       │            │                        ┌─ Escherichia coli (636-866/1127) B354   
       │            │                        │┌─ Escherichia coli (636-866/1127) MS 21-1   
       │            └────────────────────────┤│    ┌─ Escherichia coli (636-866/1127) H299 (18)  
       │                                     ││   ┌┴─ Escherichia coli (636-866/1127) 2362-75 (2)  
       │                                     └┤  ┌┴─ Escherichia coli (637-867/1128) 536 (7)  
       │                                      │ ┌┴─ Escherichia coli (706-936/1197) SMS-3-5   
       │                                      │┌┴─ Escherichia coli (636-866/1127) IAI39 (1)  
       │                                      └┤┌─ Escherichia coli (706-936/1197) K12 (19)  
       │                                       └┤ ┌─ Escherichia coli (636-866/1127) M718   
       │                                        └┬┴─ Escherichia coli (636-866/1127) MS 187-1   
 ┌─────┤                                         └┬─ Escherichia coli (637-867/1128) B185   
 │     │                                          └┬─ Escherichia coli (636-866/1127) FVEC1302 (6)  
 │     │                                           └┬─ Escherichia coli (706-936/1197) E110019 (1)  
 │     │                                            └┬─ fig|1040638.4.peg.2785 O104:H4 (463-693/954) str. LB226692 (36)  
 │     │                                             └─ Escherichia coli (636-866/1127) 1044A (25)  
 │     │                                                  ┌─ Escherichia coli (391-618/756) 1044A (23)  
 │     │                                                 ┌┴─ Escherichia coli (391-618/756) O157:H7 str. EC508   
 │     │                                                ┌┴─ Escherichia coli (388-615/753) M718 (1)  
 │     │                  ┌─────────────────────────────┴─ Escherichia coli (388-615/753) B185   
 │     │             ┌────┴───────────────────────────────────┬─ Escherichia coli (332-551/556) 2362-75 (27)  
 │     │             │                                        └─ Escherichia coli (332-551/556) SE15   
 │     │             │                              ┌─ Escherichia coli (386-600/608) B354   
 │     │             │                             ┌┴─ Escherichia coli (390-604/612) 042 (9)  
 │     │             │                            ┌┴─ Escherichia coli (386-600/608) IAI39 (2)  
 │     │             │                           ┌┴┬─ Escherichia coli (386-600/608) ETEC H10407   
 │     │             │                          ┌┤ └─ Escherichia coli (386-600/608) K12 (26)  
 │     └─────────────┤                         ┌┤└─ Escherichia coli (386-600/608) MS 21-1   
 │                   │          ┌──────────────┤└─ Escherichia coli (386-600/608) H299   
 │                   │          │              └┬─ Escherichia coli (386-600/608) ED1a (1)  
 │                   │     ┌────┤               └─ Escherichia coli (386-600/608) 2362-75 (26)  
 │                   │     │    └──────────────────────────────────┬─ Escherichia coli (129-347/349) IAI39 (2)  
 │                   │     │                                       └┬─ Escherichia coli (129-347/349) 2362-75 (28)  
 │                   │     │                                        └┬─ Escherichia coli (129-347/349) B354   
 │                   └─────┤                                         └┬─ Escherichia coli (129-347/349) MS 21-1   
 │                         │                                          └─ Escherichia coli (129-347/349) K12 (98)  
┌┤                         │                   ┌─ Escherichia coli (240-449/458) O157:H7 EDL933 (1)  
││                         │                  ┌┴─ Escherichia coli (240-449/458) 1044A (23)  
││                         │                 ┌┴─ Escherichia coli (240-449/458) M718   
││                         └─────────────────┤┌─ Escherichia coli (240-449/458) SMS-3-5   
││                                           ││ ┌─ Escherichia coli (237-446/455) 042 (1)  
││                                           └┤┌┴─ Escherichia coli (240-449/458) FVEC1302 (4)  
││                                            ││  ┌─ Escherichia coli (247-456/465) MS 69-1   
││                                            ││ ┌┴─ Escherichia coli (240-449/458) B354   
││                                            └┤┌┴─ Escherichia coli (237-446/455) TA280   
││                                             ││     ┌─ Escherichia coli (240-449/458) 1827-70 (25)  
││                                             ││    ┌┴─ fig|1040638.4.peg.1033 O104:H4 (240-449/458) str. LB226692 (5)  
││                                             └┤   ┌┴─ Escherichia coli (240-449/458) MS 124-1 (1)  
││                                              │  ┌┴─ Escherichia coli (247-456/465) K12 (13)  
││                                              │ ┌┴─ Escherichia coli (240-449/458) E110019 (1)  
││                                              │┌┴┬─ Escherichia coli (240-449/458) 101-1 (7)  
││                                              └┤ └─ Escherichia coli (240-449/458) B str. REL606 (3)  
││                                               │┌─ Escherichia coli (240-449/458) APEC O1 (6)  
││                                               └┤ ┌─ Escherichia coli (240-449/458) ED1a (4)  
││                                                └┬┴─ Escherichia coli (240-449/458) 2362-75 (8)  
││                                                 └┬─ Escherichia coli (240-449/458) M605   
││                                                  └┬─ Escherichia coli (237-446/455) H299   
││                                                   └┬─ Escherichia coli (240-449/458) SE15   
││                                                    └─ Escherichia coli (240-449/458) 83972 (8)  
││              ┌────────────────────────── Escherichia coli (172-403/410) O157:H7 str. EC4024   
││              │                     ┌─ Escherichia coli (257-462/474) SMS-3-5   
│└──────────────┤                     │   ┌─ Escherichia coli (257-462/474) ATCC 8739 (1)  
│               │                     │  ┌┴─ Escherichia coli (257-462/474) 042 (20)  
│               └─────────────────────┤ ┌┴─ Escherichia coli (257-462/474) 53638 (1)  
│                                     │┌┴─ Escherichia coli (257-462/474) 1044A (25)  
│                                     ││    ┌─ Escherichia coli (257-462/474) MS 145-7   
│                                     ││   ┌┴─ Escherichia coli (257-462/474) E22 (1)  
│                                     └┤  ┌┴─ fig|1040638.4.peg.818 O104:H4 (257-462/474) str. LB226692 (27)  
│                                      │ ┌┴─ Escherichia coli (257-462/474) H299   
│                                      │┌┴─ Escherichia coli (257-462/474) 536 (5)  
│                                      └┤┌─ Escherichia coli (257-462/474) TA280   
│                                       ││    ┌─ Escherichia coli (257-462/474) SE15   
┤                                       └┤   ┌┴─ Escherichia coli (257-462/474) FVEC1302 (2)  
│                                        │  ┌┴─ Escherichia coli (257-462/474) TA143   
│                                        │ ┌┴─ Escherichia coli (257-462/474) K12 (12)  
│                                        └┬┴─ Escherichia coli (257-462/474) B354   
│                                         └┬─ Escherichia coli (257-462/474) B185   
│                                          └┬─ Escherichia coli (257-462/474) IAI39 (1)  
│                                           └┬─ Escherichia coli (257-462/474) ED1a (3)  
│                                            └┬─ Escherichia coli (257-462/474) TA206   
│                                             └┬─ Escherichia coli (257-462/474) 83972 (12)  
│                                              └─ Escherichia coli (257-462/474) MS 185-1   
│                                  ┌─────── Escherichia coli (260-490/490) 536 (13)  
│ ┌────────────────────────────────┴── Escherichia coli (269-490/490) MS 185-1   
│ │                                          ┌─ Escherichia coli (675-892/906) ATCC 8739 (1)  
│ │                                         ┌┴─ Escherichia coli (664-880/894) TA280   
│ │                                        ┌┴─ Escherichia coli (664-880/894) H299 (1)  
│ │                                       ┌┴─ Escherichia coli (664-880/894) K12 (92)  
│ │                                      ┌┴─ Escherichia coli (664-880/894) B185   
│ │                                     ┌┴┬─ Escherichia coli (675-891/905) 042 (2)  
│ │                                     │ └┬─ Escherichia coli (664-880/894) SE11   
│ │                                     │  └┬─ Escherichia coli (664-880/894) SE15 (1)  
│ │            ┌────────────────────────┤   └┬─ Escherichia coli (664-880/894) 2362-75 (25)  
│ │            │                        │    └─ Escherichia coli (664-881/894) TA206   
│ │          ┌─┤                        └─ Escherichia coli (664-880/894) MS 115-1   
│ │          │ │                                                   ┌─ Escherichia coli (250-484/486) 53638 (6)  
│ │          │ └───────────────────────────────────────────────────┤┌─ Escherichia coli (250-484/486) CFT073   
│ │          │                                                     └┤ ┌─ Escherichia coli (250-484/486) SMS-3-5   
│ │          │                                                      └┬┴─ Escherichia coli (250-484/486) ED1a (1)  
│ │          │                                                       └┬─ Escherichia coli (250-484/486) K12 (84)  
│ │          │                                                        └┬─ Escherichia coli (250-484/486) 2362-75   
│ │      ┌───┤                                                         └┬─ Escherichia coli (250-484/486) 1044A (24)  
│ │      │   │                                                          └┬─ Escherichia coli (250-484/486) B185 (5)  
│ │      │   │                                                           └┬─ Escherichia coli (250-484/486) B str. REL606 (4)  
│ │      │   │                                                            └─ Escherichia coli (250-484/486) 101-1   
│ │      │   │                        ┌─ Escherichia coli (241-459/467) E24377A (1)  
│ │      │   │                       ┌┴─ Escherichia coli (241-459/467) E110019 (9)  
│ │      │   └───────────────────────┤ ┌─ Escherichia coli (241-459/467) SMS-3-5   
└─┤      │                           │┌┴─ Escherichia coli (241-459/467) B354   
  │      │                           └┤┌─ fig|1040638.4.peg.3160 O104:H4 (241-459/467) str. LB226692 (36)  
  │      │                            └┤ ┌─ Escherichia coli (241-459/467) K12 (45)  
  │      │                             └┬┴─ Escherichia coli (241-459/467) B088 (4)  
  │      │                              └┬─ Escherichia coli (223-459/467) IAI39 (1)  
  │      │                               └┬─ Escherichia coli (223-459/467) 83972 (1)  
  │      │                                └┬─ Escherichia coli (241-459/467) 2362-75 (2)  
  │      │                                 └┬─ Escherichia coli (223-459/467) APEC O1 (16)  
  │      │                                  └┬─ Escherichia coli (223-459/467) SE15 (1)  
  │      │                                   └─ Escherichia coli (223-459/467) 536 (4)  
  │      │                                                ┌─ fig|1040638.4.peg.5258 O104:H4 (217-445/448) str. LB226692 (24)  
  │      │                                               ┌┴─ Escherichia coli (251-479/482) ETEC H10407   
  │      │                                              ┌┴─ Escherichia coli (251-479/482) B str. REL606 (3)  
  │      │                                             ┌┴─ Escherichia coli (251-479/482) B185   
  │      │                                            ┌┴─ Escherichia coli (251-479/482) MS 69-1   
  │      │                                           ┌┴─ Escherichia coli (251-479/482) 53638 (13)  
  │      │                                          ┌┤ ┌─ Escherichia coli (251-479/482) M718   
  │      │                                          │└┬┴─ Escherichia coli (251-479/482) 1044A (25)  
  │      │                                         ┌┤ └┬─ Escherichia coli (255-483/486) 042 (1)  
  │      │                                         ││  └─ Escherichia coli (251-479/482) FVEC1302 (3)  
  │      │                                         │└┬─ Escherichia coli (251-479/480) TA280   
  │      │                                         │ └┬─ Escherichia coli (251-479/480) B354   
  │      │                                        ┌┤  └─ Escherichia coli (251-479/480) IAI39 (2)  
  │      │                                        ││  ┌─ Escherichia coli (251-479/480) H299   
  │      │                                        ││ ┌┴─ Escherichia coli (251-479/480) 2362-75 (2)  
  │      │                                        │└┬┴─ Escherichia coli (251-479/480) SMS-3-5   
  └──────┤                                        │ └┬─ Escherichia coli (251-479/480) M605 (2)  
         │                                       ┌┤  └┬─ Escherichia coli (251-479/480) SE15   
         │                                       ││   └┬─ Escherichia coli (251-479/480) 536 (4)  
         │                                       ││    └┬─ Escherichia coli (251-479/480) MS 185-1   
         │                                   ┌───┤│     └─ Escherichia coli (251-479/480) 83972 (15)  
         │                                   │   │└─ Escherichia coli (251-479/480) TA143   
         │              ┌────────────────────┤   └┬─ Escherichia coli (251-479/482) E110019 (1)  
         │              │                    │    └─ Escherichia coli (251-479/480) K12 (14)  
         │              │                    └────────┬─ Escherichia coli (270-488/491) ETEC H10407   
         │              │                             └┬─ Escherichia coli (270-488/491) ATCC 8739 (1)  
         │ ┌────────────┤                              └┬─ fig|1040638.4.peg.2103 O104:H4 (270-480/493) str. LB226692 (5)  
         │ │            │                               └─ Escherichia coli (270-480/493) MS 115-1 (1)  
         │ │            │                       ┌─ Escherichia coli (197-422/431) MS 124-1 (1)  
         │ │            └───────────────────────┤┌─ Escherichia coli (197-422/431) MS 21-1 (1)  
         │ │                                    ││  ┌─ Escherichia coli (197-422/431) H299   
         │ │                                    └┤ ┌┴─ Escherichia coli (197-422/431) SMS-3-5   
         │ │                                     │┌┴┬─ Escherichia coli (197-422/431) 1044A (24)  
         │ │                                     ││ └─ Escherichia coli (197-422/431) 101-1 (7)  
         │ │                                     └┤ ┌─ fig|1040638.4.peg.5083 O104:H4 (197-422/431) str. LB226692 (64)  
         │ │                                      │┌┴─ Escherichia coli (197-422/431) SE15   
         │ │                                      └┤ ┌─ Escherichia coli (197-422/431) 2362-75 (2)  
         │ │                                       │┌┴─ Escherichia coli (197-422/431) 536 (4)  
         │ │                                       └┤ ┌─ Escherichia coli (197-422/431) TA280   
         │ │                                        └┬┴─ Escherichia coli (197-422/431) B185   
         │ │                                         └┬─ Escherichia coli (197-422/431) K12 (13)  
         │ │                                          └┬─ Escherichia coli (197-422/431) NC101   
         │ │                                           └─ Escherichia coli (197-422/431) 53638 (1)  
         │ │                                            ┌─ fig|1040638.4.peg.2368 O104:H4 (231-449/449) str. LB226692 (26)  
         │ │                                           ┌┴─ Escherichia coli (231-449/449) E22 (1)  
         │ │                                          ┌┴─ Escherichia coli (231-449/449) E110019 (1)  
         │ │                                         ┌┴─ Escherichia coli (231-449/449) IAI39 (1)  
         │ │                                        ┌┴┬─ Escherichia coli (231-449/449) K12 (27)  
         │ │                                       ┌┤ └─ Escherichia coli (231-449/449) ATCC 8739 (1)  
         └─┤                                       │└┬─ Escherichia coli (231-449/449) E2348/69 (2)  
           │                                       │ └┬─ Escherichia coli (231-449/449) B354 (1)  
           │                                      ┌┤  └┬─ Escherichia coli (231-449/449) 042 (2)  
           │                                      ││   └─ Escherichia coli (231-449/449) H299   
           │                                      │└┬─ Escherichia coli (231-449/449) MS 78-1   
           │                                     ┌┤ └┬─ Escherichia coli (127-345/345) MS 21-1   
           │                                     ││  └─ Escherichia coli (231-449/449) MS 196-1 (1)  
           │                                     ││┌─ Escherichia coli (231-449/449) WV_060327   
           │                                     │└┤┌─ Escherichia coli (231-449/449) 536 (2)  
           │                                     │ └┤  ┌─ Escherichia coli (231-449/449) APEC O1 (6)  
           │                                     │  │ ┌┴─ Escherichia coli (231-449/449) MS 200-1   
           │                                    ┌┤  └┬┴─ Escherichia coli (231-449/449) M605   
           │                                    ││   └┬─ Escherichia coli (231-449/449) NC101 (1)  
           │                                    ││    └┬─ Escherichia coli (231-449/449) F11 (2)  
           │                  ┌─────────────────┤│     └┬─ Escherichia coli (231-449/449) 83972 (6)  
           │                  │                 ││      └─ Escherichia coli (231-449/449) ED1a (1)  
           │           ┌──────┤                 │└─ Escherichia coli (58-276/276) O157:H7 str. Sakai (28)  
           │           │      │                 └─ Escherichia coli (231-449/449) MS 84-1   
           │  ┌────────┤      └───────────────────────────────── Escherichia coli (8-230/239) O157:H7 str. EC4024   
           │  │        └──────────────────────── Escherichia coli (165-387/400) O157:H7 str. EC4024   
           │  │                                                  ┌─ Escherichia coli (228-454/457) MS 115-1   
           │  │                                                 ┌┴─ Escherichia coli (228-454/457) WV_060327   
           │  │                                                ┌┴┬─ Escherichia coli (228-454/457) M718   
           │  │                                               ┌┤ └─ Escherichia coli (228-454/457) 101-1 (5)  
           └──┤                                              ┌┤└─ Escherichia coli (228-454/457) K12 (115)  
              │                                             ┌┤└─ Escherichia coli (228-454/457) O157:H7 EDL933 (1)  
              │             ┌───────────────────────────────┤└─ Escherichia coli (228-454/457) 042 (4)  
              │             │                               └─ Escherichia coli (228-454/457) MS 198-1   
              │             │                                 ┌─ Escherichia coli (223-429/450) IAI1 (1)  
              │             │                                ┌┴─ Escherichia coli (223-429/450) MS 146-1   
              └─────────────┤                               ┌┴─ Escherichia coli (223-429/450) K12 (125)  
                            │                              ┌┴─ Escherichia coli (223-429/450) IAI39 (1)  
                            │                             ┌┴─ Escherichia coli (223-429/450) O26:H11 str. 11368   
                            │    ┌────────────────────────┴─ Escherichia coli (223-429/450) MS 21-1   
                            └────┤            ┌───── Escherichia coli (201-427/432) O157:H7 str. EC4024   
                                 └────────────┤   ┌─ Escherichia coli (201-433/433) MS 185-1   
                                              │   │  ┌─ fig|1040638.4.peg.3657 O104:H4 str. LB226692 (44)  
                                              └───┤ ┌┴─ Escherichia coli (201-433/433) H299   
                                                  │┌┴─ Escherichia coli (201-433/433) MS 182-1 (1)  
                                                  └┤┌─ Escherichia coli (201-433/433) K12 (30)  
                                                   └┤┌─ Escherichia coli (201-433/433) M718   
                                                    └┤  ┌─ Escherichia coli (201-433/433) B185   
                                                     │ ┌┴─ Escherichia coli (201-433/433) 1044A (30)  
                                                     └┬┴─ Escherichia coli (201-433/433) 101-1 (12)  
                                                      └┬─ Escherichia coli (201-433/433) B354 (1)  
                                                       └┬─ Escherichia coli (201-433/433) TA280   
                                                        └─ Escherichia coli (201-433/433) MS 21-1   
  
Copper sensory histidine kinase CusS (26)
Sensory histidine kinase QseC (23)
Sensor protein torS (EC 2.7.3.-) (22)
Sensor protein of zinc sigma-54-dependent two-component system (22)
Two-component response regulator CreC (21)
Phosphate regulon sensor protein PhoR (SphS) (EC 2.7.13.3) (14)
Hybrid sensory histidine kinase in two-component regulatory system with EvgA (14)
Osmosensitive K+ channel histidine kinase KdpD (EC 2.7.3.-) (13)
Sensory histidine kinase in two-component regulatory system with RstA (12)
Sensory histidine kinase BaeS (12)
Aerobic respiration control sensor protein arcB (EC 2.7.3.-) (11)
Sensor protein PhoQ (EC 2.7.13.3) (10)
Copper sensory histidine kinase CpxA (8)
Sensory histidine kinase AtoS (8)
Osmolarity sensory histidine kinase EnvZ (6)
Two-component sensor protein RcsC (EC 2.7.3.-) (6)
Nitrogen regulation protein NR(II) (EC 2.7.3.-) (5)
Putative histidine kinase (4)
BarA sensory histidine kinase (= VarS = GacS) (3)
Putative transport sensor protein (2)
Others (15)