┌─ Escherichia coli (1-274/293) 1044A (23)  
                                                           ┌┴─ Escherichia coli (1-274/293) O157:H7 EDL933 (1)  
                                                          ┌┴┬─ Escherichia coli (1-274/293) B185   
                                                         ┌┤ └─ Escherichia coli (1-274/293) M718   
                                                         │└┬─ Escherichia coli (1-274/293) B7A (2)  
                                                        ┌┤ └─ Escherichia coli (1-274/293) B171 (16)  
                                                        │└┬─ Escherichia coli (1-274/293) EC4100B   
                                                       ┌┤ └─ fig|1040638.4.peg.4278 O104:H4 (1-274/293) str. LB226692 (12)  
                                                      ┌┤└─ Escherichia coli (1-274/293) 53638 (1)  
                                                      │└┬─ Escherichia coli (3-274/293) ETEC H10407   
                                                     ┌┤ └─ Escherichia coli (1-274/293) K12 (23)  
                                                     │└─ Escherichia coli (1-274/293) B354 (4)  
                                                    ┌┤ ┌─ Escherichia coli (1-274/293) SMS-3-5   
                                                    │└┬┴─ Escherichia coli (1-274/293) MS 21-1   
                                                    │ └┬─ Escherichia coli (1-274/293) SE15   
                                                    │  └┬─ Escherichia coli (1-274/293) 536 (22)  
                                                   ┌┤   └┬─ Escherichia coli (1-274/293) WV_060327   
                                                   ││    └┬─ Escherichia coli (1-274/293) E2348/69 (1)  
                                                   ││     └─ Escherichia coli (1-274/293) 2362-75   
                     ┌─────────────────────────────┤└┬─ Escherichia coli (1-274/291) FVEC1302 (3)  
                     │                             │ └─ Escherichia coli (1-274/291) H299   
             ┌───────┤                             └─ Escherichia coli (1-274/291) 042 (1)  
             │       └───────────────────────────────────────────── Escherichia coli (1-277/297) TA206   
             │                                   ┌─ Escherichia coli (1-280/293) K12 (80)  
             │                                  ┌┴─ Escherichia coli (1-280/293) MS 21-1   
         ┌───┤                                 ┌┴─ Escherichia coli (1-280/293) O111:H- str. 11128 (1)  
         │   │                                ┌┴─ Escherichia coli (1-280/293) 042 (6)  
         │   │        ┌───────────────────────┴─ Escherichia coli (1-280/293) B354   
         │   │        │                                    ┌─ Escherichia coli (4-294/311) 042 (1)  
         │   └────────┤                                   ┌┴─ Escherichia coli (4-294/311) MS 69-1   
         │            │                                  ┌┴─ Escherichia coli (4-294/311) FVEC1302 (5)  
         │            │                                  │  ┌─ Escherichia coli (4-294/311) MS 185-1   
         │            └──────────────────────────────────┤ ┌┴─ Escherichia coli (4-294/311) 83972 (11)  
         │                                               │┌┴┬─ Escherichia coli (4-294/311) WV_060327   
         │                                               └┤ └─ Escherichia coli (4-294/311) 2362-75 (18)  
    ┌────┤                                                └┬─ Escherichia coli (4-294/311) B185 (1)  
    │    │                                                 └┬─ fig|1040638.4.peg.2736 O104:H4 (4-294/311) str. LB226692 (28)  
    │    │                                                  └┬─ Escherichia coli (4-294/311) MS 182-1 (1)  
    │    │                                                   └┬─ Escherichia coli (4-294/311) E24377A (3)  
    │    │                                                    └┬─ Escherichia coli (4-294/311) O157:H7 EDL933 (1)  
    │    │                                                     └─ Escherichia coli (4-294/311) 1044A (23)  
    │    │                                       ┌─ Escherichia coli (1-282/293) O26:H11 str. 11368   
    │    │                                       │     ┌─ Escherichia coli (1-282/293) M718   
    │    │                                       │    ┌┴─ Escherichia coli (16-297/308) 1044A (25)  
    │    └───────────────────────────────────────┤   ┌┴─ Escherichia coli (1-282/293) B185   
    │                                            │  ┌┴─ fig|1040638.4.peg.3008 O104:H4 (1-282/293) str. LB226692 (3)  
    │                                            │ ┌┴─ Escherichia coli (16-297/308) B171 (15)  
    │                                            │┌┴─ Escherichia coli (1-282/293) ETEC H10407   
  ┌─┤                                            └┤┌─ Escherichia coli (16-297/308) B088   
  │ │                                             └┤ ┌─ Escherichia coli (1-282/293) FVEC1302 (3)  
  │ │                                              │┌┴─ Escherichia coli (16-297/308) 042 (1)  
  │ │                                              └┤┌─ Escherichia coli (16-297/308) EC4100B   
  │ │                                               └┤┌─ Escherichia coli (1-282/293) K12 (24)  
  │ │                                                └┤ ┌─ Escherichia coli (1-282/293) H299 (3)  
  │ │                                                 └┬┴─ Escherichia coli (1-282/293) ED1a (1)  
  │ │                                                  └┬─ Escherichia coli (1-282/293) NC101   
  │ │                                                   └┬─ Escherichia coli (1-282/293) 2362-75 (2)  
  │ │                                                    └┬─ Escherichia coli (1-282/293) APEC O1 (6)  
  │ │                                                     └─ Escherichia coli (1-282/293) 536 (12)  
┌─┤ │                                           ┌─ Escherichia coli (27-304/323) B185   
│ │ └───────────────────────────────────────────┤┌─ Escherichia coli (27-304/323) IAI39 (2)  
│ │                                             ││   ┌─ Escherichia coli (27-304/323) O111:H- str. 11128   
│ │                                             └┤  ┌┴─ Escherichia coli (27-304/323) K12 (16)  
│ │                                              │ ┌┴─ Escherichia coli (27-304/323) E110019 (1)  
│ │                                              │┌┴─ fig|1040638.4.peg.2153 O104:H4 (27-304/323) str. LB226692 (32)  
│ │                                              └┤ ┌─ Escherichia coli (27-304/323) M605 (1)  
│ │                                               └┬┴─ Escherichia coli (27-304/323) 2362-75 (2)  
│ │                                                └┬─ Escherichia coli (27-304/323) 1827-70 (4)  
│ │                                                 └┬─ Escherichia coli (27-304/323) 1044A (25)  
│ │                                                  └─ Escherichia coli (27-304/323) 53638 (1)  
│ └─────────────────────────────────────── Escherichia coli (1-288/311) MS 119-7   
│                                                    ┌─ Escherichia coli E22 (2)  
│                                                   ┌┴─ Escherichia coli B171 (1)  
│                                                  ┌┴─ Escherichia coli O111:H- str. 11128 (1)  
│                                                 ┌┴┬─ Escherichia coli KO11 (2)  
│                                                 │ └┬─ Escherichia coli 53638 (1)  
│                                                ┌┤  └─ Escherichia coli K12 (22)  
│                                               ┌┤└─ Escherichia coli E110019 (1)  
│                                               │└┬─ fig|1040638.4.peg.3641 O104:H4 str. LB226692 (3)  
│                                              ┌┤ └─ Escherichia coli 042 (48)  
│                                             ┌┤└─ Escherichia coli MS 21-1   
│                                            ┌┤└─ Escherichia coli EC4100B   
│                                            │└┬─ Escherichia coli SMS-3-5   
│                                           ┌┤ └─ Escherichia coli B354   
│                                          ┌┤└─ Escherichia coli MS 115-1   
│                             ┌────────────┤└─ Escherichia coli O83:H1 str. NRG 857C (1)  
│                             │            └┬─ Escherichia coli FVEC1302 (5)  
│                             │             └┬─ Escherichia coli ED1a (1)  
│                             │              └┬─ Escherichia coli 2362-75 (10)  
│                      ┌──────┤               └┬─ Escherichia coli 83972 (12)  
│                      │      │                └─ Escherichia coli E2348/69 (1)  
│                      │      │                     ┌── Escherichia coli (7-292/294) IAI39 (1)  
│                      │      └─────────────────────┤    ┌─ Escherichia coli (8-292/294) K12 (15)  
┤                      │                            └───┬┴─ Escherichia coli (8-292/294) TA143   
│                 ┌────┤                                └┬─ Escherichia coli (8-292/294) TA271   
│                 │    │                                 └┬─ Escherichia coli (8-292/294) H591 (7)  
│                 │    │                                  └┬─ fig|1040638.4.peg.2817 O104:H4 (8-292/294) str. LB226692 (2)  
│                 │    │                                   └─ Escherichia coli (8-292/294) E22 (2)  
│     ┌───────────┤    └───────────────────────────┬─ Escherichia coli (2-289/295) B354   
│     │           │                                └┬─ Escherichia coli (2-289/295) FVEC1302 (5)  
│     │           │                                 └─ Escherichia coli (2-289/295) TA280   
│     │           │                     ┌─ Escherichia coli (2-284/297) TA280   
│     │           └─────────────────────┤┌─ Escherichia coli (2-284/297) IAI39 (3)  
│     │                                 └┤┌─ Escherichia coli (1-283/296) B354 (2)  
│     │                                  └┤┌─ Escherichia coli (32-314/327) 042 (6)  
│  ┌──┤                                   └┤┌─ Escherichia coli (1-283/296) K12 (15)  
│  │  │                                    └┤ ┌─ fig|1040638.4.peg.2965 O104:H4 (2-284/297) str. LB226692 (65)  
│  │  │                                     └┬┴─ Escherichia coli (1-283/296) E22 (1)  
│  │  │                                      └┬─ Escherichia coli (2-284/297) B185   
│  │  │                                       └─ Escherichia coli (23-305/318) B7A (4)  
│  │  │                            ┌─ Escherichia coli (4-282/299) TA280   
│  │  │                            │ ┌─ Escherichia coli (4-282/299) K12 (13)  
│  │  └────────────────────────────┤┌┴─ Escherichia coli (4-282/299) B185 (2)  
│  │                               ││┌─ Escherichia coli (12-290/307) MS 69-1 (18)  
│  │                               └┤│    ┌─ Escherichia coli (12-290/307) 042 (1)  
│  │                                ││   ┌┴─ Escherichia coli (12-290/307) FVEC1302 (3)  
│  │                                └┤  ┌┴─ Escherichia coli (12-290/307) TA143   
│  │                                 │ ┌┴─ Escherichia coli (4-282/299) B354   
│  │                                 │┌┴─ Escherichia coli (16-294/311) MS 115-1 (2)  
│  │                                 └┤ ┌─ Escherichia coli (1-271/288) MS 78-1   
│  │                                  │┌┴─ Escherichia coli (4-282/299) IAI39 (3)  
│  │                                  └┤ ┌─ Escherichia coli (12-290/307) MS 119-7 (4)  
│  │                                   └┬┴─ Escherichia coli (12-290/307) E22 (9)  
│  │                                    └┬─ Escherichia coli (4-282/299) O55:H7 str. CB9615   
│  │                                     └─ Escherichia coli (12-290/307) O157:H7 str. EC4486 (24)  
│  │                                               ┌─ Escherichia coli (1-292/317) SMS-3-5   
│  │                                              ┌┴─ Escherichia coli (1-292/317) B185 (1)  
└──┤                                             ┌┴┬─ Escherichia coli (1-285/310) M605   
   │                                            ┌┤ └─ Escherichia coli (1-292/317) SE15   
   │                                            │└┬─ Escherichia coli (1-292/317) IAI1 (1)  
   │                                           ┌┤ └─ fig|6666666.5357.peg.2190 TY-2482 (1-292/317) strain (92)  
   │                                          ┌┤└─ Escherichia coli (22-313/338) 53638 (1)  
   │                                         ┌┤└─ Escherichia coli (1-292/317) MS 21-1   
   │                                         │└┬─ Escherichia coli (1-292/317) E24377A (2)  
   │                                        ┌┤ └─ Escherichia coli (1-285/310) HS (1)  
   │                                        │└┬─ Escherichia coli (1-292/317) MS 187-1   
   │                                       ┌┤ └─ Escherichia coli (1-292/317) MS 115-1   
   │                                       │└┬─ Escherichia coli (1-285/310) K12   
   │                                      ┌┤ └─ Escherichia coli (1-292/317) BW2952 (6)  
   │              ┌───────────────────────┤└─ Escherichia coli (1-285/310) B354   
   │             ┌┤                       └─ Escherichia coli (1-285/310) B171  [2] 
   │   ┌─────────┤└─────────────────────── Escherichia coli (1-282/308) MS 116-1 (1)  
   │   │         └───────────────────────────── Escherichia coli (1-284/296) B7A (7)  
   │   │                                                               ┌─ Escherichia coli (10-287/312) MS 116-1 (1)  
   │   │                                                              ┌┴─ Escherichia coli (10-287/312) MS 115-1   
   │   │                                                             ┌┴─ Escherichia coli (10-287/312) MS 21-1   
   │   │                                                            ┌┴─ Escherichia coli (10-287/312) K12 (120)  
   │   │                                                           ┌┴┬─ Escherichia coli (10-287/312) O111:H- str. 11128   
   │   │                                                          ┌┤ └─ Escherichia coli (10-287/312) B088   
   │   │                                                          │└┬─ Escherichia coli (10-287/312) IAI1 (1)  
   └───┤                                        ┌─────────────────┤ └┬─ Escherichia coli (10-287/312) M605 (1)  
       │                                        │                 │  └─ Escherichia coli (10-287/312) B354   
       │                        ┌───────────────┤                 └─ Escherichia coli (10-287/312) O26:H11 str. 11368   
       │         ┌──────────────┤               └──────────────────── Escherichia coli (13-285/309) 53638   
       │      ┌──┤              └───────────────────── Escherichia coli (5-284/302) HS (1)  
       │      │  └────────────────────────────────────────────── Escherichia coli (4-291/293) H591 (2)  
       │      │                                                     ┌─ Escherichia coli (12-280/310) K12 (68)  
       │      │                                                    ┌┴─ Escherichia coli (12-280/310) O103:H2 str. 12009   
       │      │                                                   ┌┴─ Escherichia coli (12-280/310) O55:H7 str. CB9615   
       │      │                                                  ┌┴┬─ Escherichia coli (12-280/310) M605 (1)  
       └──────┤                                                  │ └┬─ Escherichia coli (12-280/310) 042 (37)  
              │                                                 ┌┤  └─ Escherichia coli (12-280/310) 2362-75   
              │                                                ┌┤└─ Escherichia coli (12-280/310) 536 (4)  
              │                                               ┌┤└─ Escherichia coli (12-280/310) WV_060327   
              │                     ┌─────────────────────────┤└─ Escherichia coli (12-280/310) 83972 (4)  
              │                     │                         └─ Escherichia coli (12-280/310) MS 185-1   
              └─────────────────────┤                    ┌─ Escherichia coli (7-275/308) TA280   
                                    │                    │    ┌─ Escherichia coli (7-275/308) 2362-75 (16)  
                                    │                    │   ┌┴─ Escherichia coli (7-275/308) APEC O1 (7)  
                                    └────────────────────┤  ┌┴─ Escherichia coli (7-275/308) O83:H1 str. NRG 857C (1)  
                                                         │ ┌┴─ Escherichia coli (7-275/308) H299   
                                                         │┌┴─ Escherichia coli (7-275/308) NC101 (1)  
                                                         └┤┌─ Escherichia coli (7-275/308) K12 (69)  
                                                          └┤┌─ Escherichia coli (7-275/308) MS 119-7   
                                                           └┤┌─ Escherichia coli (7-275/308) HS (1)  
                                                            └┤ ┌─ Escherichia coli (7-275/308) FVEC1302 (3)  
                                                             └┬┴─ Escherichia coli (7-275/308) B185   
                                                              └┬─ Escherichia coli (7-275/308) O103:H2 str. 12009   
                                                               └─ fig|6666666.5357.peg.4889 TY-2482 (7-275/308) strain (11)  
  
LysR family transcriptional regulator YnfL (22)
LysR family transcriptional regulator YneJ (21)
LysR family transcriptional regulator YfiE (17)
LysR family transcriptional regulator YbhD (15)
Cyn operon transcriptional activator (15)
Transcriptional activator protein LysR (12)
DNA-binding transcriptional activator of the allD operon (12)
Threonine catabolic operon transcriptional activator TdcA (10)
LysR family transcriptional regulator YhjC (10)
Hypothetical lysR-family transcriptional regulator YdhB (10)
Hca operon (3-phenylpropionic acid catabolism) transcriptional activator HcaR (8)
Xanthosine operon regulatory protein XapR, LysR family (6)
LysR family transcriptional regulator YeiE (5)
LysR family transcriptional regulator YfeR (1)
putative transcriptional regulatory protein, LysR family (1)
Transcriptional regulator, LysR family (1)
Regulatory protein (induces abgABT, used to catabolize p-aminobenzoyl-glutamate) (1)
Malonate utilization transcriptional regulator (1)
LysR family transcriptional regulator near succinyl-CoA:3-ketoacid-coenzyme A transferase (1)
HTH-type transcriptional regulator tdcA (1)
Others (9)