fig|1040638.4.peg.364
Escherichia coli O104:H4 str. LB226692
M
EI
SA
NA
F
NRY
E
SV
A
R
T
M
V
P
K
IG
G
S
R
L
V
SS
V
TKE
E
LL
Y
I
RKDLLTGYQ
NS
M
KNK--
A
A
KGRSVVTVNYYMTT
I
AGMFQFA
A
D
H
GYL
EA
NPF
Q
GI
K
PLK
R
A
R
AE
PDPLTRDEFIRLIDACRHQQTKNLW
S
L
AVYTG
M
RHGEL
V
S
LAWEDIDLKAGTITIRRN
Y
TK
L
G
E
FT
L
PKT
E
A
S
TNRV
V
HLI
Q
PAI
SV
LK
N
QA
E
M
TRL
G
KQ
Y
N
I
K
V
Q
LREYGR
S
VN
H
E
CTFVF
N
PQV
VR
K
SEQV
G
F
V
Y
K
VDS
V
G
DS
W
E
T
AIKRAG
I
RHRK
A
YQSRHTYACWSL
S
AGANP
S
FIASQMGHA
S
AQMVFNVYGAWM
T
D
S
N
AE
Q
I
A
M
LN
QK
L
TD
Y
V
P
M
MPH
SH
Q
S
DTRGLLKSVS
fig|6666666.5357.peg.320
Escherichia coli TY-2482 (97-436/436)
M
EI
SA
NA
F
NRY
E
SV
A
R
T
M
V
P
K
IG
G
S
R
L
V
SS
V
TKE
E
LL
Y
I
RKDLLTGYQ
NS
M
KNK--
A
A
KGRSVVTVNYYMTT
I
AGMFQFA
A
D
H
GYL
EA
NPF
Q
GI
K
PLK
R
A
R
AE
PDPLTRDEFIRLIDACRHQQTKNLW
S
L
AVYTG
M
RHGEL
V
S
LAWEDIDLKAGTITIRRN
Y
TK
L
G
E
FT
L
PKT
E
A
S
TNRV
V
HLI
Q
PAI
SV
LK
N
QA
E
M
TRL
G
KQ
Y
N
I
K
V
Q
LREYGR
S
VN
H
E
CTFVF
N
PQV
VR
K
SEQV
G
F
V
Y
K
VDS
V
G
DS
W
E
T
AIKRAG
I
RHRK
A
YQSRHTYACWSL
S
AGANP
S
FIASQMGHA
S
AQMVFNVYGAWM
T
D
S
N
AE
Q
I
A
M
LN
QK
L
TD
Y
V
P
M
MPH
SH
Q
S
DTRGLLKSVS
fig|562.375.peg.2078
Escherichia coli EC4100B (97-436/436)
M
EI
SA
NA
F
NRY
E
SV
A
R
T
M
V
P
K
IG
G
S
R
L
V
SS
V
TKE
E
LL
Y
I
RKDLLTGYQ
NS
M
KNK--
A
A
KGRSVVTVNYYMTT
I
AGMFQFA
A
D
H
GYL
EA
NPF
Q
GI
K
PLK
R
A
R
AE
PDPLTRDEFIRLIDACRHQQTKNLW
S
L
AVYTG
M
RHGEL
V
S
LAWEDIDLKAGTITIRRN
Y
TK
L
G
E
FT
L
PKT
E
A
S
TNRV
V
HLI
Q
PAI
SV
LK
N
QA
E
M
TRL
G
KQ
Y
N
I
K
V
Q
LREYGR
S
VN
H
E
CTFVF
N
PQV
VR
K
SEQV
G
F
V
Y
K
VDS
V
G
DS
W
E
T
AIKRAG
I
RHRK
A
YQSRHTYACWSL
S
AGANP
S
FIASQMGHA
S
AQMVFNVYGAWM
T
D
S
N
AE
Q
I
A
M
LN
QK
L
TD
Y
V
P
M
MPH
SH
Q
S
DTRGLLKSVS
fig|344601.3.peg.3668
Escherichia coli B171 (97-437/437)
M
EI
SA
NA
F
NRY
E
SV
A
R
T
M
V
P
K
IG
G
S
R
L
V
SS
V
TKE
E
LL
Y
I
RKDLLTGYQ
NS
T
KNK-V
A
A
KGRSVVTVNYYMTT
I
AGMFQFA
A
D
H
GYL
EA
NPF
Q
GI
K
PLK
R
A
R
AE
PDPLTRDEFIRLIDACRHQQTKNLW
S
L
AVYTG
M
RHGEL
V
S
LAWEDIDLKAGTITIRRN
Y
TK
L
G
E
FT
L
PKT
E
A
S
TNRV
V
HLI
Q
PAI
SV
LK
N
QA
E
M
TRL
G
KQ
Y
N
I
K
V
Q
LREY
R
R
S
VN
H
E
CTFVF
N
PQV
VR
K
SEQV
G
F
V
Y
K
VDS
V
G
DS
W
E
T
AIKRAG
I
RHRK
A
YQSRHTYACWSL
S
AGANP
S
FIASQMGHA
S
AQMVFNVYGAWM
T
D
S
N
AE
Q
I
A
M
LN
QK
L
TD
Y
V
P
M
MPH
SH
Q
S
DTRGLLKSVS
fig|344601.5.peg.3828
Escherichia coli B171 (97-437/437)
M
EI
SA
NA
F
NRY
E
SV
A
R
T
M
V
P
K
IG
G
S
R
L
V
SS
V
TKE
E
LL
Y
I
RKDLLTGYQ
NS
T
KNK-V
A
A
KGRSVVTVNYYMTT
I
AGMFQFA
A
D
H
GYL
EA
NPF
Q
GI
K
PLK
R
A
R
AE
PDPLTRDEFIRLIDACRHQQTKNLW
S
L
AVYTG
M
RHGEL
V
S
LAWEDIDLKAGTITIRRN
Y
TK
L
G
E
FT
L
PKT
E
A
S
TNRV
V
HLI
Q
PAI
SV
LK
N
QA
E
M
TRL
G
KQ
Y
N
I
K
V
Q
LREY
R
R
S
VN
H
E
CTFVF
N
PQV
VR
K
SEQV
G
F
V
Y
K
VDS
V
G
DS
W
E
T
AIKRAG
I
RHRK
A
YQSRHTYACWSL
S
AGANP
S
FIASQMGHA
S
AQMVFNVYGAWM
T
D
S
N
AE
Q
I
A
M
LN
QK
L
TD
Y
V
P
M
MPH
SH
Q
S
DTRGLLKSVS
fig|585397.7.peg.2164
Escherichia coli ED1a (97-437/437)
M
EI
SA
NA
F
NRY
E
SV
A
R
T
M
V
S
K
IG
G
S
R
L
V
SS
V
TKE
E
LL
Y
I
RKDLLTGYQ
NS
T
KNK-A
A
A
KGRSVVTVNYYMTT
I
AGMFQFA
A
D
H
GYL
EA
NPF
Q
GI
K
PLK
R
A
R
AE
PDPLTRDEFIRLIDACRHQQTKNLW
S
L
AVYTG
M
RHGEL
V
S
LAWEDIDLKAGTITIRRN
Y
TK
L
G
E
FT
L
PKT
E
A
S
TNRV
V
HLI
Q
PAI
SV
LK
N
QA
E
M
TRL
G
KQ
Y
N
I
K
V
Q
LREYGR
S
VN
H
E
CTFVF
N
PQV
VR
K
SEQV
G
F
V
Y
K
VDS
V
G
DS
W
E
T
AIKRAG
I
RHRK
A
YQSRHTYACWSL
S
AGANP
S
FIASQMGHA
S
AQMVFNVYGAWM
T
D
S
N
AE
Q
I
A
M
LN
QK
L
TD
Y
V
P
M
MPH
SH
Q
S
DTRGLLKSVS
fig|585397.9.peg.2160
Escherichia coli ED1a (97-437/437)
M
EI
SA
NA
F
NRY
E
SV
A
R
T
M
V
S
K
IG
G
S
R
L
V
SS
V
TKE
E
LL
Y
I
RKDLLTGYQ
NS
T
KNK-A
A
A
KGRSVVTVNYYMTT
I
AGMFQFA
A
D
H
GYL
EA
NPF
Q
GI
K
PLK
R
A
R
AE
PDPLTRDEFIRLIDACRHQQTKNLW
S
L
AVYTG
M
RHGEL
V
S
LAWEDIDLKAGTITIRRN
Y
TK
L
G
E
FT
L
PKT
E
A
S
TNRV
V
HLI
Q
PAI
SV
LK
N
QA
E
M
TRL
G
KQ
Y
N
I
K
V
Q
LREYGR
S
VN
H
E
CTFVF
N
PQV
VR
K
SEQV
G
F
V
Y
K
VDS
V
G
DS
W
E
T
AIKRAG
I
RHRK
A
YQSRHTYACWSL
S
AGANP
S
FIASQMGHA
S
AQMVFNVYGAWM
T
D
S
N
AE
Q
I
A
M
LN
QK
L
TD
Y
V
P
M
MPH
SH
Q
S
DTRGLLKSVS
fig|344610.3.peg.2968
Escherichia coli 53638 (97-437/437)
M
EI
SA
NA
F
NRY
E
SV
A
R
T
M
V
P
K
IG
G
G
R
L
V
SS
V
TKE
E
LL
Y
I
RKDLLTGYQ
NS
T
KNK-A
A
A
KGRSVVTVNYYMTT
I
AGMFQFA
A
D
H
GYL
EA
NPF
Q
GI
K
PLK
R
A
R
AE
PDPLTRDEFIRLIDACRHQQTKNLW
S
L
AVYTG
M
RHGEL
V
S
LAWEDIDLKAGTITIRRN
Y
TK
L
G
E
FT
L
PKT
E
A
S
TNRV
V
HLI
Q
PAI
SV
LK
N
QA
E
M
TRL
G
KQH
H
I
K
V
Q
LREYGR
S
VN
H
E
CTFVF
N
PQV
VR
K
SKQV
G
F
I
Y
K
VDSI
G
DS
W
E
T
AIKRAG
I
RHRK
A
YQSRHTYACWSL
S
AGANP
S
FIASQMGHA
S
AQMVFNVYGAWM
T
D
S
N
AE
Q
I
A
M
LN
QK
L
AD
Y
V
P
M
M
S
H
G
H
Q
S
DTRGLLKSVS
fig|344610.7.peg.4746
Escherichia coli 53638 (97-437/437)
M
EI
SA
NA
F
NRY
E
SV
A
R
T
M
V
P
K
IG
G
G
R
L
V
SS
V
TKE
E
LL
Y
I
RKDLLTGYQ
NS
T
KNK-A
A
A
KGRSVVTVNYYMTT
I
AGMFQFA
A
D
H
GYL
EA
NPF
Q
GI
K
PLK
R
A
R
AE
PDPLTRDEFIRLIDACRHQQTKNLW
S
L
AVYTG
M
RHGEL
V
S
LAWEDIDLKAGTITIRRN
Y
TK
L
G
E
FT
L
PKT
E
A
S
TNRV
V
HLI
Q
PAI
SV
LK
N
QA
E
M
TRL
G
KQH
H
I
K
V
Q
LREYGR
S
VN
H
E
CTFVF
N
PQV
VR
K
SKQV
G
F
I
Y
K
VDSI
G
DS
W
E
T
AIKRAG
I
RHRK
A
YQSRHTYACWSL
S
AGANP
S
FIASQMGHA
S
AQMVFNVYGAWM
T
D
S
N
AE
Q
I
A
M
LN
QK
L
AD
Y
V
P
M
M
S
H
G
H
Q
S
DTRGLLKSVS
fig|409438.11.peg.2255
Escherichia coli SE11 (97-436/437)
M
EI
SA
NA
F
NRY
E
SV
A
R
T
M
V
P
K
IG
G
S
R
L
V
SS
V
TKE
E
LL
Y
I
RKDLLTGYQ
NS
T
KNK-A
A
A
KGRSVVTVNYYMTT
I
AGMFQFA
A
D
H
GYL
EA
NPF
Q
GI
K
PLK
R
A
R
AE
PDPLTRDEFIRLIDACRHQQTKNLW
S
L
AVYTG
M
RHGEL
V
S
LAWEDIDLKAGTITIRRN
Y
TK
L
G
E
FT
L
PKT
E
A
S
TNRV
V
HLI
Q
PAI
SV
LK
N
QA
E
M
TRL
G
KQH
H
I
K
V
Q
LREYGR
S
VN
H
E
CTFVF
N
PQV
VR
K
SKQV
G
F
I
Y
K
VDSI
G
DS
W
E
T
AIKRAG
I
RHRK
A
YQSRHTYACWSL
S
AGANP
S
FIASQMGHA
S
AQMVFNVYGAWM
T
D
S
N
AE
Q
I
A
M
LN
QK
L
AD
Y
V
P
M
M
S
H
G
H
Q
S
DTR
D
LLKSV
fig|585395.4.peg.2227
Escherichia coli O103:H2 str. 12009 (97-436/437)
M
EI
SA
NA
F
NRY
E
SV
A
R
T
M
V
P
K
IG
G
S
R
L
V
S
T
V
TKE
E
LL
Y
I
RKDLLTG
H
Q
NP
T
KGK-A
P
V
KGRSVVTVNYYMTT
I
AGMFQFA
A
D
H
GYL
EA
NPF
E
GI
K
PLK
KA
R
AE
PDPLTRDEFIRLIDACRHQQTKNLW
S
L
AVYTG
M
RHGEL
V
S
LAWEDIDLKAGTITIRRN
Y
TK
L
D
E
FT
L
PKT
E
A
S
TNRVIHLI
Q
PAI
SV
LK
N
QA
E
M
TRL
G
KQH
H
I
K
V
Q
LREYGR
S
VN
H
E
CTFVF
N
PQV
VR
K
SKQV
G
F
I
Y
K
VDSI
G
DS
W
E
SAIKRAG
I
RHRK
A
YQSRHTYACWSL
S
AGANP
S
FIASQMGHA
S
AQMVFNVYGAWM
T
D
S
N
AE
Q
I
A
M
LN
QK
L
AD
Y
V
P
M
M
S
H
G
H
Q
S
DTR
D
LLKSV
fig|340185.3.peg.3834
Escherichia coli E22 (97-424/428)
IEI
GS
NA
F
S
RYQSV
V
R
NMLP
R
IG
E
K
R
LASS
V
TKEDLL
F
I
RKDLLTGY
H
NL
S
NGKTT
P
I
KGRSVVTVNYYMTT
I
AGMFQFA
A
DNGY
I
VS
NPFNG
L
T
PLK
R
SR
TE
PDPLTRDEFIR
F
IDAC
H
HQQTKNLW
S
L
AVYTGIRHGEL
I
S
LAWEDIDLKA
K
T
M
TIRRN
Y
TK
L
G
E
FT
L
PKT
E
AGT
D
RVIHL
V
Q
PA
V
DALKSQA
E
M
TRL
G
P
Q
Y
Q
I
D
V
K
LRE
F
GRT
AR
H
E
CTFVF
N
PQ
L
VK
K
CQQV
G
H
HY
K
A
DSIR
DS
W
A
SA
L
R
RAGLRHRK
A
YQSRHTYACW
A
L
S
AGANP
S
FIA
N
QMGHA
N
AQMVFNVYGAWM
K
D
NN
IG
Q
IE
LLN
KQ
L
T
E
S
V
P
Y
MPH
fig|340185.4.peg.4044
Escherichia coli E22 (97-424/428)
IEI
GS
NA
F
S
RYQSV
V
R
NMLP
R
IG
E
K
R
LASS
V
TKEDLL
F
I
RKDLLTGY
H
NL
S
NGKTT
P
I
KGRSVVTVNYYMTT
I
AGMFQFA
A
DNGY
I
VS
NPFNG
L
T
PLK
R
SR
TE
PDPLTRDEFIR
F
IDAC
H
HQQTKNLW
S
L
AVYTGIRHGEL
I
S
LAWEDIDLKA
K
T
M
TIRRN
Y
TK
L
G
E
FT
L
PKT
E
AGT
D
RVIHL
V
Q
PA
V
DALKSQA
E
M
TRL
G
P
Q
Y
Q
I
D
V
K
LRE
F
GRT
AR
H
E
CTFVF
N
PQ
L
VK
K
CQQV
G
H
HY
K
A
DSIR
DS
W
A
SA
L
R
RAGLRHRK
A
YQSRHTYACW
A
L
S
AGANP
S
FIA
N
QMGHA
N
AQMVFNVYGAWM
K
D
NN
IG
Q
IE
LLN
KQ
L
T
E
S
V
P
Y
MPH
fig|585396.4.peg.2543
Escherichia coli O111:H- str. 11128 (97-424/428)
IEI
GS
NA
F
S
RYQSV
V
R
NMLP
R
IG
E
K
R
LASS
V
TKEDLL
F
I
RKDLLTGY
H
NL
S
NGKTT
P
I
KGRSVVTVNYYMTT
I
AGMFQFA
A
DNGY
I
VS
NPFNG
L
T
PLK
R
SR
TE
PDPLTRDEFIR
F
IDAC
H
HQQTKNLW
S
L
AVYTGIRHGEL
I
S
LAWEDIDLKA
K
T
M
TIRRN
Y
TK
L
G
E
FT
L
PKT
E
AGT
D
RVIHL
V
Q
PA
V
DALKSQA
E
M
TRL
G
P
Q
Y
Q
I
D
V
K
LRE
F
GRT
AR
H
E
CTFVF
N
PQ
L
VK
K
CQQV
G
H
HY
K
A
DSIR
DS
W
A
SA
L
R
RAGLRHRK
A
YQSRHTYACW
A
L
S
AGANP
S
FIA
N
QMGHA
N
AQMVFNVYGAWM
K
D
NN
IG
Q
IE
LLN
KQ
L
T
E
S
V
P
Y
MPH
fig|478008.5.peg.4045
Escherichia coli O157:H7 str. EC869 (97-424/428)
IEI
CA
NALNRYQSVIKNMLP
M
L
G
E
K
K
L
V
SSITKEDLL
F
VR
R
DLLTGYQ
KL
S
NGKTS
S
I
KGRSVVTVNYYMTT
I
AGMFQFA
T
DNGY
T
SG
NPFNG
L
A
PLK
K
S
K
VK
PDPLTRDEFIR
F
I
E
ACRHQQTKNLW
I
L
AVYTGIRHGEL
V
S
LAWEDIDLKA
R
TITIRRN
Y
TK
L
G
E
FT
P
PKT
D
AGT
G
R
T
IHL
V
Q
PAIDALKSQA
E
M
T
M
L
G
KQH
S
V
E
V
K
LREYGRT
AV
HKCTFVF
S
PQV
TK
Q
QQLS
G
P
HY
K
VDSIR
ES
W
T
S
IL
KRAGLRHRKSYQSRHTYACWSL
A
AGANP
S
FIASQMGH
T
N
AQMVFNVYGAWM
K
D
NN
HE
Q
IE
LLN
KR
LSE
S
V
P
C
MPH
fig|637388.3.peg.467
Escherichia coli O157:H7 str. FRIK2000 (97-424/428)
IEI
CA
NALNRYQSVIKNMLP
M
L
G
E
K
K
L
V
SSITKEDLL
F
VR
R
DLLTGYQ
KL
S
NGKTS
S
I
KGRSVVTVNYYMTT
I
AGMFQFA
T
DNGY
T
SG
NPFNG
L
A
PLK
K
S
K
VK
PDPLTRDEFIR
F
I
E
ACRHQQTKNLW
I
L
AVYTGIRHGEL
V
S
LAWEDIDLKA
R
TITIRRN
Y
TK
L
G
E
FT
P
PKT
D
AGT
G
R
T
IHL
V
Q
PAIDALKSQA
E
M
T
M
L
G
KQH
S
V
E
V
K
LREYGRT
AV
HKCTFVF
S
PQV
TK
Q
QQLS
G
P
HY
K
VDSIR
ES
W
T
S
IL
KRAGLRHRKSYQSRHTYACWSL
A
AGANP
S
FIASQMGH
T
N
AQMVFNVYGAWM
K
D
NN
HE
Q
IE
LLN
KR
LSE
S
V
P
C
MPH
fig|570506.3.peg.4865
Escherichia coli O157:H7 str. FRIK966 (97-424/428)
IEI
CA
NALNRYQSVIKNMLP
M
L
G
E
K
K
L
V
SSITKEDLL
F
VR
R
DLLTGYQ
KL
S
NGKTS
S
I
KGRSVVTVNYYMTT
I
AGMFQFA
T
DNGY
T
SG
NPFNG
L
A
PLK
K
S
K
VK
PDPLTRDEFIR
F
I
E
ACRHQQTKNLW
I
L
AVYTGIRHGEL
V
S
LAWEDIDLKA
R
TITIRRN
Y
TK
L
G
E
FT
P
PKT
D
AGT
G
R
T
IHL
V
Q
PAIDALKSQA
E
M
T
M
L
G
KQH
S
V
E
V
K
LREYGRT
AV
HKCTFVF
S
PQV
TK
Q
QQLS
G
P
HY
K
VDSIR
ES
W
T
S
IL
KRAGLRHRKSYQSRHTYACWSL
A
AGANP
S
FIASQMGH
T
N
AQMVFNVYGAWM
K
D
NN
HE
Q
IE
LLN
KR
LSE
S
V
P
C
MPH
fig|562.371.peg.4971
Escherichia coli 1044A (97-424/428)
IEI
CA
NALNRYQSVIKNMLP
M
L
G
E
K
K
L
V
SSITKEDLL
F
VR
R
DLLTGYQ
KL
S
NGKTS
S
I
KGRSVVTVNYYMTT
I
AGMFQFA
T
DNGY
T
SG
NPFNG
L
A
PLK
K
S
K
VK
PDPLTRDEFIR
F
I
E
ACRHQQTKNLW
I
L
AVYTGIRHGEL
V
S
LAWEDIDLKA
R
TITIRRN
Y
TK
L
G
E
FT
P
PKT
D
AGT
G
R
T
IHL
V
Q
PAIDALKSQA
E
M
T
M
L
G
KQH
S
V
E
V
K
Q
REYGRT
AV
HKCTFVF
S
PQV
TK
Q
QQLS
G
P
HY
K
VDSIR
ES
W
T
S
IL
KRAGLRHRKSYQSRHTYACWSL
A
AGANP
S
FIASQMGH
T
N
AQMVFNVYGAWM
K
D
NN
HE
Q
IE
LLN
KR
LSE
S
V
P
C
MPH
fig|562.373.peg.3860
Escherichia coli 1125A (97-424/428)
IEI
CA
NALNRYQSVIKNMLP
M
L
G
E
K
K
L
V
SSITKEDLL
F
VR
R
DLLTGYQ
KL
S
NGKTS
S
I
KGRSVVTVNYYMTT
I
AGMFQFA
T
DNGY
T
SG
NPFNG
L
A
PLK
K
S
K
VK
PDPLTRDEFIR
F
I
E
ACRHQQTKNLW
I
L
AVYTGIRHGEL
V
S
LAWEDIDLKA
R
TITIRRN
Y
TK
L
G
E
FT
P
PKT
D
AGT
G
R
T
IHL
V
Q
PAIDALKSQA
E
M
T
M
L
G
KQH
S
V
E
V
K
Q
REYGRT
AV
HKCTFVF
S
PQV
TK
Q
QQLS
G
P
HY
K
VDSIR
ES
W
T
S
IL
KRAGLRHRKSYQSRHTYACWSL
A
AGANP
S
FIASQMGH
T
N
AQMVFNVYGAWM
K
D
NN
HE
Q
IE
LLN
KR
LSE
S
V
P
C
MPH
fig|562.372.peg.5657
Escherichia coli 1212A (97-424/428)
IEI
CA
NALNRYQSVIKNMLP
M
L
G
E
K
K
L
V
SSITKEDLL
F
VR
R
DLLTGYQ
KL
S
NGKTS
S
I
KGRSVVTVNYYMTT
I
AGMFQFA
T
DNGY
T
SG
NPFNG
L
A
PLK
K
S
K
VK
PDPLTRDEFIR
F
I
E
ACRHQQTKNLW
I
L
AVYTGIRHGEL
V
S
LAWEDIDLKA
R
TITIRRN
Y
TK
L
G
E
FT
P
PKT
D
AGT
G
R
T
IHL
V
Q
PAIDALKSQA
E
M
T
M
L
G
KQH
S
V
E
V
K
Q
REYGRT
AV
HKCTFVF
S
PQV
TK
Q
QQLS
G
P
HY
K
VDSIR
ES
W
T
S
IL
KRAGLRHRKSYQSRHTYACWSL
A
AGANP
S
FIASQMGH
T
N
AQMVFNVYGAWM
K
D
NN
HE
Q
IE
LLN
KR
LSE
S
V
P
C
MPH
fig|670897.3.peg.3096
Escherichia coli 2362-75 (97-424/428)
IEI
CA
NALNRYQSVIKNMLP
M
L
G
E
K
K
L
V
SSITKEDLL
F
VR
R
DLLTGYQ
KL
S
NGKTS
S
I
KGRSVVTVNYYMTT
I
AGMFQFA
T
DNGY
T
SG
NPFNG
L
A
PLK
K
S
K
VK
PDPLTRDEFIR
F
I
E
ACRHQQTKNLW
I
L
AVYTGIRHGEL
V
S
LAWEDIDLKA
R
TITIRRN
Y
TK
L
G
E
FT
P
PKT
D
AGT
G
R
T
IHL
V
Q
PAIDALKSQA
E
M
T
M
L
G
KQH
S
V
E
V
K
Q
REYGRT
AV
HKCTFVF
S
PQV
TK
Q
QQLS
G
P
HY
K
VDSIR
ES
W
T
S
IL
KRAGLRHRKSYQSRHTYACWSL
A
AGANP
S
FIASQMGH
T
N
AQMVFNVYGAWM
K
D
NN
HE
Q
IE
LLN
KR
LSE
S
V
P
C
MPH
fig|562.374.peg.3259
Escherichia coli 536A (97-424/428)
IEI
CA
NALNRYQSVIKNMLP
M
L
G
E
K
K
L
V
SSITKEDLL
F
VR
R
DLLTGYQ
KL
S
NGKTS
S
I
KGRSVVTVNYYMTT
I
AGMFQFA
T
DNGY
T
SG
NPFNG
L
A
PLK
K
S
K
VK
PDPLTRDEFIR
F
I
E
ACRHQQTKNLW
I
L
AVYTGIRHGEL
V
S
LAWEDIDLKA
R
TITIRRN
Y
TK
L
G
E
FT
P
PKT
D
AGT
G
R
T
IHL
V
Q
PAIDALKSQA
E
M
T
M
L
G
KQH
S
V
E
V
K
Q
REYGRT
AV
HKCTFVF
S
PQV
TK
Q
QQLS
G
P
HY
K
VDSIR
ES
W
T
S
IL
KRAGLRHRKSYQSRHTYACWSL
A
AGANP
S
FIASQMGH
T
N
AQMVFNVYGAWM
K
D
NN
HE
Q
IE
LLN
KR
LSE
S
V
P
C
MPH
fig|562.375.peg.3102
Escherichia coli EC4100B (97-424/428)
IEI
CA
NALNRYQSVIKNMLP
M
L
G
E
K
K
L
V
SSITKEDLL
F
VR
R
DLLTGYQ
KL
S
NGKTS
S
I
KGRSVVTVNYYMTT
I
AGMFQFA
T
DNGY
T
SG
NPFNG
L
A
PLK
K
S
K
VK
PDPLTRDEFIR
F
I
E
ACRHQQTKNLW
I
L
AVYTGIRHGEL
V
S
LAWEDIDLKA
R
TITIRRN
Y
TK
L
G
E
FT
P
PKT
D
AGT
G
R
T
IHL
V
Q
PAIDALKSQA
E
M
T
M
L
G
KQH
S
V
E
V
K
Q
REYGRT
AV
HKCTFVF
S
PQV
TK
Q
QQLS
G
P
HY
K
VDSIR
ES
W
T
S
IL
KRAGLRHRKSYQSRHTYACWSL
A
AGANP
S
FIASQMGH
T
N
AQMVFNVYGAWM
K
D
NN
HE
Q
IE
LLN
KR
LSE
S
V
P
C
MPH
fig|83334.1.peg.3007
Escherichia coli O157:H7 (97-424/428)
IEI
CA
NALNRYQSVIKNMLP
M
L
G
E
K
K
L
V
SSITKEDLL
F
VR
R
DLLTGYQ
KL
S
NGKTS
S
I
KGRSVVTVNYYMTT
I
AGMFQFA
T
DNGY
T
SG
NPFNG
L
A
PLK
K
S
K
VK
PDPLTRDEFIR
F
I
E
ACRHQQTKNLW
I
L
AVYTGIRHGEL
V
S
LAWEDIDLKA
R
TITIRRN
Y
TK
L
G
E
FT
P
PKT
D
AGT
G
R
T
IHL
V
Q
PAIDALKSQA
E
M
T
M
L
G
KQH
S
V
E
V
K
Q
REYGRT
AV
HKCTFVF
S
PQV
TK
Q
QQLS
G
P
HY
K
VDSIR
ES
W
T
S
IL
KRAGLRHRKSYQSRHTYACWSL
A
AGANP
S
FIASQMGH
T
N
AQMVFNVYGAWM
K
D
NN
HE
Q
IE
LLN
KR
LSE
S
V
P
C
MPH
fig|155864.1.peg.3011
Escherichia coli O157:H7 EDL933 (97-424/428)
IEI
CA
NALNRYQSVIKNMLP
M
L
G
E
K
K
L
V
SSITKEDLL
F
VR
R
DLLTGYQ
KL
S
NGKTS
S
I
KGRSVVTVNYYMTT
I
AGMFQFA
T
DNGY
T
SG
NPFNG
L
A
PLK
K
S
K
VK
PDPLTRDEFIR
F
I
E
ACRHQQTKNLW
I
L
AVYTGIRHGEL
V
S
LAWEDIDLKA
R
TITIRRN
Y
TK
L
G
E
FT
P
PKT
D
AGT
G
R
T
IHL
V
Q
PAIDALKSQA
E
M
T
M
L
G
KQH
S
V
E
V
K
Q
REYGRT
AV
HKCTFVF
S
PQV
TK
Q
QQLS
G
P
HY
K
VDSIR
ES
W
T
S
IL
KRAGLRHRKSYQSRHTYACWSL
A
AGANP
S
FIASQMGH
T
N
AQMVFNVYGAWM
K
D
NN
HE
Q
IE
LLN
KR
LSE
S
V
P
C
MPH
fig|155864.8.peg.2895
Escherichia coli O157:H7 EDL933 (97-424/428)
IEI
CA
NALNRYQSVIKNMLP
M
L
G
E
K
K
L
V
SSITKEDLL
F
VR
R
DLLTGYQ
KL
S
NGKTS
S
I
KGRSVVTVNYYMTT
I
AGMFQFA
T
DNGY
T
SG
NPFNG
L
A
PLK
K
S
K
VK
PDPLTRDEFIR
F
I
E
ACRHQQTKNLW
I
L
AVYTGIRHGEL
V
S
LAWEDIDLKA
R
TITIRRN
Y
TK
L
G
E
FT
P
PKT
D
AGT
G
R
T
IHL
V
Q
PAIDALKSQA
E
M
T
M
L
G
KQH
S
V
E
V
K
Q
REYGRT
AV
HKCTFVF
S
PQV
TK
Q
QQLS
G
P
HY
K
VDSIR
ES
W
T
S
IL
KRAGLRHRKSYQSRHTYACWSL
A
AGANP
S
FIASQMGH
T
N
AQMVFNVYGAWM
K
D
NN
HE
Q
IE
LLN
KR
LSE
S
V
P
C
MPH
fig|444454.5.peg.1928
Escherichia coli O157:H7 str. EC4024 (97-424/428)
IEI
CA
NALNRYQSVIKNMLP
M
L
G
E
K
K
L
V
SSITKEDLL
F
VR
R
DLLTGYQ
KL
S
NGKTS
S
I
KGRSVVTVNYYMTT
I
AGMFQFA
T
DNGY
T
SG
NPFNG
L
A
PLK
K
S
K
VK
PDPLTRDEFIR
F
I
E
ACRHQQTKNLW
I
L
AVYTGIRHGEL
V
S
LAWEDIDLKA
R
TITIRRN
Y
TK
L
G
E
FT
P
PKT
D
AGT
G
R
T
IHL
V
Q
PAIDALKSQA
E
M
T
M
L
G
KQH
S
V
E
V
K
Q
REYGRT
AV
HKCTFVF
S
PQV
TK
Q
QQLS
G
P
HY
K
VDSIR
ES
W
T
S
IL
KRAGLRHRKSYQSRHTYACWSL
A
AGANP
S
FIASQMGH
T
N
AQMVFNVYGAWM
K
D
NN
HE
Q
IE
LLN
KR
LSE
S
V
P
C
MPH
fig|444449.5.peg.1388
Escherichia coli O157:H7 str. EC4042 (97-424/428)
IEI
CA
NALNRYQSVIKNMLP
M
L
G
E
K
K
L
V
SSITKEDLL
F
VR
R
DLLTGYQ
KL
S
NGKTS
S
I
KGRSVVTVNYYMTT
I
AGMFQFA
T
DNGY
T
SG
NPFNG
L
A
PLK
K
S
K
VK
PDPLTRDEFIR
F
I
E
ACRHQQTKNLW
I
L
AVYTGIRHGEL
V
S
LAWEDIDLKA
R
TITIRRN
Y
TK
L
G
E
FT
P
PKT
D
AGT
G
R
T
IHL
V
Q
PAIDALKSQA
E
M
T
M
L
G
KQH
S
V
E
V
K
Q
REYGRT
AV
HKCTFVF
S
PQV
TK
Q
QQLS
G
P
HY
K
VDSIR
ES
W
T
S
IL
KRAGLRHRKSYQSRHTYACWSL
A
AGANP
S
FIASQMGH
T
N
AQMVFNVYGAWM
K
D
NN
HE
Q
IE
LLN
KR
LSE
S
V
P
C
MPH
fig|444448.5.peg.151
Escherichia coli O157:H7 str. EC4045 (97-424/428)
IEI
CA
NALNRYQSVIKNMLP
M
L
G
E
K
K
L
V
SSITKEDLL
F
VR
R
DLLTGYQ
KL
S
NGKTS
S
I
KGRSVVTVNYYMTT
I
AGMFQFA
T
DNGY
T
SG
NPFNG
L
A
PLK
K
S
K
VK
PDPLTRDEFIR
F
I
E
ACRHQQTKNLW
I
L
AVYTGIRHGEL
V
S
LAWEDIDLKA
R
TITIRRN
Y
TK
L
G
E
FT
P
PKT
D
AGT
G
R
T
IHL
V
Q
PAIDALKSQA
E
M
T
M
L
G
KQH
S
V
E
V
K
Q
REYGRT
AV
HKCTFVF
S
PQV
TK
Q
QQLS
G
P
HY
K
VDSIR
ES
W
T
S
IL
KRAGLRHRKSYQSRHTYACWSL
A
AGANP
S
FIASQMGH
T
N
AQMVFNVYGAWM
K
D
NN
HE
Q
IE
LLN
KR
LSE
S
V
P
C
MPH
fig|444453.5.peg.4957
Escherichia coli O157:H7 str. EC4076 (97-424/428)
IEI
CA
NALNRYQSVIKNMLP
M
L
G
E
K
K
L
V
SSITKEDLL
F
VR
R
DLLTGYQ
KL
S
NGKTS
S
I
KGRSVVTVNYYMTT
I
AGMFQFA
T
DNGY
T
SG
NPFNG
L
A
PLK
K
S
K
VK
PDPLTRDEFIR
F
I
E
ACRHQQTKNLW
I
L
AVYTGIRHGEL
V
S
LAWEDIDLKA
R
TITIRRN
Y
TK
L
G
E
FT
P
PKT
D
AGT
G
R
T
IHL
V
Q
PAIDALKSQA
E
M
T
M
L
G
KQH
S
V
E
V
K
Q
REYGRT
AV
HKCTFVF
S
PQV
TK
Q
QQLS
G
P
HY
K
VDSIR
ES
W
T
S
IL
KRAGLRHRKSYQSRHTYACWSL
A
AGANP
S
FIASQMGH
T
N
AQMVFNVYGAWM
K
D
NN
HE
Q
IE
LLN
KR
LSE
S
V
P
C
MPH
fig|444452.5.peg.3438
Escherichia coli O157:H7 str. EC4113 (97-424/428)
IEI
CA
NALNRYQSVIKNMLP
M
L
G
E
K
K
L
V
SSITKEDLL
F
VR
R
DLLTGYQ
KL
S
NGKTS
S
I
KGRSVVTVNYYMTT
I
AGMFQFA
T
DNGY
T
SG
NPFNG
L
A
PLK
K
S
K
VK
PDPLTRDEFIR
F
I
E
ACRHQQTKNLW
I
L
AVYTGIRHGEL
V
S
LAWEDIDLKA
R
TITIRRN
Y
TK
L
G
E
FT
P
PKT
D
AGT
G
R
T
IHL
V
Q
PAIDALKSQA
E
M
T
M
L
G
KQH
S
V
E
V
K
Q
REYGRT
AV
HKCTFVF
S
PQV
TK
Q
QQLS
G
P
HY
K
VDSIR
ES
W
T
S
IL
KRAGLRHRKSYQSRHTYACWSL
A
AGANP
S
FIASQMGH
T
N
AQMVFNVYGAWM
K
D
NN
HE
Q
IE
LLN
KR
LSE
S
V
P
C
MPH
fig|444450.8.peg.3241
Escherichia coli O157:H7 str. EC4115 (97-424/428)
IEI
CA
NALNRYQSVIKNMLP
M
L
G
E
K
K
L
V
SSITKEDLL
F
VR
R
DLLTGYQ
KL
S
NGKTS
S
I
KGRSVVTVNYYMTT
I
AGMFQFA
T
DNGY
T
SG
NPFNG
L
A
PLK
K
S
K
VK
PDPLTRDEFIR
F
I
E
ACRHQQTKNLW
I
L
AVYTGIRHGEL
V
S
LAWEDIDLKA
R
TITIRRN
Y
TK
L
G
E
FT
P
PKT
D
AGT
G
R
T
IHL
V
Q
PAIDALKSQA
E
M
T
M
L
G
KQH
S
V
E
V
K
Q
REYGRT
AV
HKCTFVF
S
PQV
TK
Q
QQLS
G
P
HY
K
VDSIR
ES
W
T
S
IL
KRAGLRHRKSYQSRHTYACWSL
A
AGANP
S
FIASQMGH
T
N
AQMVFNVYGAWM
K
D
NN
HE
Q
IE
LLN
KR
LSE
S
V
P
C
MPH
fig|444451.5.peg.4758
Escherichia coli O157:H7 str. EC4196 (97-424/428)
IEI
CA
NALNRYQSVIKNMLP
M
L
G
E
K
K
L
V
SSITKEDLL
F
VR
R
DLLTGYQ
KL
S
NGKTS
S
I
KGRSVVTVNYYMTT
I
AGMFQFA
T
DNGY
T
SG
NPFNG
L
A
PLK
K
S
K
VK
PDPLTRDEFIR
F
I
E
ACRHQQTKNLW
I
L
AVYTGIRHGEL
V
S
LAWEDIDLKA
R
TITIRRN
Y
TK
L
G
E
FT
P
PKT
D
AGT
G
R
T
IHL
V
Q
PAIDALKSQA
E
M
T
M
L
G
KQH
S
V
E
V
K
Q
REYGRT
AV
HKCTFVF
S
PQV
TK
Q
QQLS
G
P
HY
K
VDSIR
ES
W
T
S
IL
KRAGLRHRKSYQSRHTYACWSL
A
AGANP
S
FIASQMGH
T
N
AQMVFNVYGAWM
K
D
NN
HE
Q
IE
LLN
KR
LSE
S
V
P
C
MPH
fig|444447.5.peg.283
Escherichia coli O157:H7 str. EC4206 (97-424/428)
IEI
CA
NALNRYQSVIKNMLP
M
L
G
E
K
K
L
V
SSITKEDLL
F
VR
R
DLLTGYQ
KL
S
NGKTS
S
I
KGRSVVTVNYYMTT
I
AGMFQFA
T
DNGY
T
SG
NPFNG
L
A
PLK
K
S
K
VK
PDPLTRDEFIR
F
I
E
ACRHQQTKNLW
I
L
AVYTGIRHGEL
V
S
LAWEDIDLKA
R
TITIRRN
Y
TK
L
G
E
FT
P
PKT
D
AGT
G
R
T
IHL
V
Q
PAIDALKSQA
E
M
T
M
L
G
KQH
S
V
E
V
K
Q
REYGRT
AV
HKCTFVF
S
PQV
TK
Q
QQLS
G
P
HY
K
VDSIR
ES
W
T
S
IL
KRAGLRHRKSYQSRHTYACWSL
A
AGANP
S
FIASQMGH
T
N
AQMVFNVYGAWM
K
D
NN
HE
Q
IE
LLN
KR
LSE
S
V
P
C
MPH
fig|478004.5.peg.4325
Escherichia coli O157:H7 str. EC4401 (97-424/428)
IEI
CA
NALNRYQSVIKNMLP
M
L
G
E
K
K
L
V
SSITKEDLL
F
VR
R
DLLTGYQ
KL
S
NGKTS
S
I
KGRSVVTVNYYMTT
I
AGMFQFA
T
DNGY
T
SG
NPFNG
L
A
PLK
K
S
K
VK
PDPLTRDEFIR
F
I
E
ACRHQQTKNLW
I
L
AVYTGIRHGEL
V
S
LAWEDIDLKA
R
TITIRRN
Y
TK
L
G
E
FT
P
PKT
D
AGT
G
R
T
IHL
V
Q
PAIDALKSQA
E
M
T
M
L
G
KQH
S
V
E
V
K
Q
REYGRT
AV
HKCTFVF
S
PQV
TK
Q
QQLS
G
P
HY
K
VDSIR
ES
W
T
S
IL
KRAGLRHRKSYQSRHTYACWSL
A
AGANP
S
FIASQMGH
T
N
AQMVFNVYGAWM
K
D
NN
HE
Q
IE
LLN
KR
LSE
S
V
P
C
MPH
fig|478005.5.peg.5167
Escherichia coli O157:H7 str. EC4486 (97-424/428)
IEI
CA
NALNRYQSVIKNMLP
M
L
G
E
K
K
L
V
SSITKEDLL
F
VR
R
DLLTGYQ
KL
S
NGKTS
S
I
KGRSVVTVNYYMTT
I
AGMFQFA
T
DNGY
T
SG
NPFNG
L
A
PLK
K
S
K
VK
PDPLTRDEFIR
F
I
E
ACRHQQTKNLW
I
L
AVYTGIRHGEL
V
S
LAWEDIDLKA
R
TITIRRN
Y
TK
L
G
E
FT
P
PKT
D
AGT
G
R
T
IHL
V
Q
PAIDALKSQA
E
M
T
M
L
G
KQH
S
V
E
V
K
Q
REYGRT
AV
HKCTFVF
S
PQV
TK
Q
QQLS
G
P
HY
K
VDSIR
ES
W
T
S
IL
KRAGLRHRKSYQSRHTYACWSL
A
AGANP
S
FIASQMGH
T
N
AQMVFNVYGAWM
K
D
NN
HE
Q
IE
LLN
KR
LSE
S
V
P
C
MPH
fig|478006.5.peg.4540
Escherichia coli O157:H7 str. EC4501 (97-424/428)
IEI
CA
NALNRYQSVIKNMLP
M
L
G
E
K
K
L
V
SSITKEDLL
F
VR
R
DLLTGYQ
KL
S
NGKTS
S
I
KGRSVVTVNYYMTT
I
AGMFQFA
T
DNGY
T
SG
NPFNG
L
A
PLK
K
S
K
VK
PDPLTRDEFIR
F
I
E
ACRHQQTKNLW
I
L
AVYTGIRHGEL
V
S
LAWEDIDLKA
R
TITIRRN
Y
TK
L
G
E
FT
P
PKT
D
AGT
G
R
T
IHL
V
Q
PAIDALKSQA
E
M
T
M
L
G
KQH
S
V
E
V
K
Q
REYGRT
AV
HKCTFVF
S
PQV
TK
Q
QQLS
G
P
HY
K
VDSIR
ES
W
T
S
IL
KRAGLRHRKSYQSRHTYACWSL
A
AGANP
S
FIASQMGH
T
N
AQMVFNVYGAWM
K
D
NN
HE
Q
IE
LLN
KR
LSE
S
V
P
C
MPH
fig|478007.5.peg.3825
Escherichia coli O157:H7 str. EC508 (97-424/428)
IEI
CA
NALNRYQSVIKNMLP
M
L
G
E
K
K
L
V
SSITKEDLL
F
VR
R
DLLTGYQ
KL
S
NGKTS
S
I
KGRSVVTVNYYMTT
I
AGMFQFA
T
DNGY
T
SG
NPFNG
L
A
PLK
K
S
K
VK
PDPLTRDEFIR
F
I
E
ACRHQQTKNLW
I
L
AVYTGIRHGEL
V
S
LAWEDIDLKA
R
TITIRRN
Y
TK
L
G
E
FT
P
PKT
D
AGT
G
R
T
IHL
V
Q
PAIDALKSQA
E
M
T
M
L
G
KQH
S
V
E
V
K
Q
REYGRT
AV
HKCTFVF
S
PQV
TK
Q
QQLS
G
P
HY
K
VDSIR
ES
W
T
S
IL
KRAGLRHRKSYQSRHTYACWSL
A
AGANP
S
FIASQMGH
T
N
AQMVFNVYGAWM
K
D
NN
HE
Q
IE
LLN
KR
LSE
S
V
P
C
MPH
fig|386585.9.peg.3136
Escherichia coli O157:H7 str. Sakai (97-424/428)
IEI
CA
NALNRYQSVIKNMLP
M
L
G
E
K
K
L
V
SSITKEDLL
F
VR
R
DLLTGYQ
KL
S
NGKTS
S
I
KGRSVVTVNYYMTT
I
AGMFQFA
T
DNGY
T
SG
NPFNG
L
A
PLK
K
S
K
VK
PDPLTRDEFIR
F
I
E
ACRHQQTKNLW
I
L
AVYTGIRHGEL
V
S
LAWEDIDLKA
R
TITIRRN
Y
TK
L
G
E
FT
P
PKT
D
AGT
G
R
T
IHL
V
Q
PAIDALKSQA
E
M
T
M
L
G
KQH
S
V
E
V
K
Q
REYGRT
AV
HKCTFVF
S
PQV
TK
Q
QQLS
G
P
HY
K
VDSIR
ES
W
T
S
IL
KRAGLRHRKSYQSRHTYACWSL
A
AGANP
S
FIASQMGH
T
N
AQMVFNVYGAWM
K
D
NN
HE
Q
IE
LLN
KR
LSE
S
V
P
C
MPH
fig|544404.4.peg.3044
Escherichia coli O157:H7 str. TW14359 (97-424/428)
IEI
CA
NALNRYQSVIKNMLP
M
L
G
E
K
K
L
V
SSITKEDLL
F
VR
R
DLLTGYQ
KL
S
NGKTS
S
I
KGRSVVTVNYYMTT
I
AGMFQFA
T
DNGY
T
SG
NPFNG
L
A
PLK
K
S
K
VK
PDPLTRDEFIR
F
I
E
ACRHQQTKNLW
I
L
AVYTGIRHGEL
V
S
LAWEDIDLKA
R
TITIRRN
Y
TK
L
G
E
FT
P
PKT
D
AGT
G
R
T
IHL
V
Q
PAIDALKSQA
E
M
T
M
L
G
KQH
S
V
E
V
K
Q
REYGRT
AV
HKCTFVF
S
PQV
TK
Q
QQLS
G
P
HY
K
VDSIR
ES
W
T
S
IL
KRAGLRHRKSYQSRHTYACWSL
A
AGANP
S
FIASQMGH
T
N
AQMVFNVYGAWM
K
D
NN
HE
Q
IE
LLN
KR
LSE
S
V
P
C
MPH
fig|502346.5.peg.4379
Escherichia coli O157:H7 str. TW14588 (97-424/428)
IEI
CA
NALNRYQSVIKNMLP
M
L
G
E
K
K
L
V
SSITKEDLL
F
VR
R
DLLTGYQ
KL
S
NGKTS
S
I
KGRSVVTVNYYMTT
I
AGMFQFA
T
DNGY
T
SG
NPFNG
L
A
PLK
K
S
K
VK
PDPLTRDEFIR
F
I
E
ACRHQQTKNLW
I
L
AVYTGIRHGEL
V
S
LAWEDIDLKA
R
TITIRRN
Y
TK
L
G
E
FT
P
PKT
D
AGT
G
R
T
IHL
V
Q
PAIDALKSQA
E
M
T
M
L
G
KQH
S
V
E
V
K
Q
REYGRT
AV
HKCTFVF
S
PQV
TK
Q
QQLS
G
P
HY
K
VDSIR
ES
W
T
S
IL
KRAGLRHRKSYQSRHTYACWSL
A
AGANP
S
FIASQMGH
T
N
AQMVFNVYGAWM
K
D
NN
HE
Q
IE
LLN
KR
LSE
S
V
P
C
MPH
fig|585397.7.peg.2573
Escherichia coli ED1a (97-424/428)
IEI
CA
NALNRYQSVIKNMLP
I
L
G
E
K
K
L
V
SSITKEDLL
F
VR
R
DLLTGYQ
KL
S
NGKTS
S
I
KGRSVVTVNYYMTT
I
AGMFQFA
T
DNGY
T
SG
NPFNG
L
A
PLK
K
S
K
VK
PDPLTRDEFIR
F
I
E
ACRHQQTKNLW
I
L
AVYTGIRHGEL
V
S
LAWEDIDLKA
R
TITIRRN
Y
TK
L
G
E
FT
P
PKT
D
AGT
G
R
T
IHL
V
Q
PAIDALKSQA
E
M
T
M
L
G
KQH
S
V
E
V
K
Q
REYGRT
AV
HKCTFVF
S
PQV
TK
Q
QQLS
G
P
HY
K
VDSIR
ES
W
T
S
IL
KRAGLRHRKSYQSRHTYACWSL
A
AGANP
S
FIASQMGH
T
N
AQMVFNVYGAWM
K
D
NN
HE
Q
IE
LLN
KR
LSE
S
V
P
C
MPH
fig|585397.9.peg.2570
Escherichia coli ED1a (97-424/428)
IEI
CA
NALNRYQSVIKNMLP
I
L
G
E
K
K
L
V
SSITKEDLL
F
VR
R
DLLTGYQ
KL
S
NGKTS
S
I
KGRSVVTVNYYMTT
I
AGMFQFA
T
DNGY
T
SG
NPFNG
L
A
PLK
K
S
K
VK
PDPLTRDEFIR
F
I
E
ACRHQQTKNLW
I
L
AVYTGIRHGEL
V
S
LAWEDIDLKA
R
TITIRRN
Y
TK
L
G
E
FT
P
PKT
D
AGT
G
R
T
IHL
V
Q
PAIDALKSQA
E
M
T
M
L
G
KQH
S
V
E
V
K
Q
REYGRT
AV
HKCTFVF
S
PQV
TK
Q
QQLS
G
P
HY
K
VDSIR
ES
W
T
S
IL
KRAGLRHRKSYQSRHTYACWSL
A
AGANP
S
FIASQMGH
T
N
AQMVFNVYGAWM
K
D
NN
HE
Q
IE
LLN
KR
LSE
S
V
P
C
MPH
fig|340186.3.peg.3723
Escherichia coli E110019 (97-424/428)
IEI
CA
NALNRYQSVIKNMLP
M
L
G
E
K
K
L
V
SSITKEDLL
F
VR
R
DLLTGYQ
KL
S
NGKTS
S
I
KGRSVVTVNYYMTT
I
AGMFQFA
T
DNGY
T
SG
NPFNG
L
A
PLK
K
S
K
VK
PDPLTRDEFIR
F
I
E
ACRHQQTKNLW
I
L
AVYTGIRHGEL
V
S
LAWEDIDLKA
R
TITIRRN
Y
TK
L
G
E
FT
P
PKT
D
AGT
G
R
T
IHL
V
Q
PAIDALKSQA
E
M
T
M
L
G
KQH
S
V
E
V
K
Q
REYGRT
AV
HKCTFVF
S
PQV
IK
Q
QLLS
G
P
HY
K
VDSIR
ES
W
T
S
IL
KRAGLRHRKSYQSRHTYACWSL
A
AGANP
S
FIASQMGH
T
N
AQMVFNVYGAWM
K
D
NN
HE
Q
IE
LLN
KR
LSE
S
V
P
C
MPH
fig|340186.5.peg.3912
Escherichia coli E110019 (97-424/428)
IEI
CA
NALNRYQSVIKNMLP
M
L
G
E
K
K
L
V
SSITKEDLL
F
VR
R
DLLTGYQ
KL
S
NGKTS
S
I
KGRSVVTVNYYMTT
I
AGMFQFA
T
DNGY
T
SG
NPFNG
L
A
PLK
K
S
K
VK
PDPLTRDEFIR
F
I
E
ACRHQQTKNLW
I
L
AVYTGIRHGEL
V
S
LAWEDIDLKA
R
TITIRRN
Y
TK
L
G
E
FT
P
PKT
D
AGT
G
R
T
IHL
V
Q
PAIDALKSQA
E
M
T
M
L
G
KQH
S
V
E
V
K
Q
REYGRT
AV
HKCTFVF
S
PQV
IK
Q
QLLS
G
P
HY
K
VDSIR
ES
W
T
S
IL
KRAGLRHRKSYQSRHTYACWSL
A
AGANP
S
FIASQMGH
T
N
AQMVFNVYGAWM
K
D
NN
HE
Q
IE
LLN
KR
LSE
S
V
P
C
MPH
fig|344601.3.peg.4890
Escherichia coli B171 (97-424/428)
IEI
CA
NALNRYQSVIKNMLP
M
L
G
E
K
K
L
V
SSITKEDLL
F
A
R
R
DLLTGYQ
KL
S
NGKIS
S
I
KGRSVVTVNYYMTT
I
AGMFQFA
T
DNGY
T
SG
NPFNG
L
A
PLK
K
S
K
VK
PDPLTRDEFIR
F
I
E
ACRHQQTKNLW
I
L
AVYTGIRHGEL
V
S
LAWEDIDLKA
R
TITIRRN
Y
TK
L
G
E
FT
P
PKT
D
AGT
G
R
T
IHL
V
Q
PAIDALKSQA
E
M
T
M
L
G
KQH
S
V
E
V
K
Q
REYGR
S
TV
HKCTFVF
S
PQV
IK
Q
RQFS
G
P
HY
K
VDSIR
ES
W
T
S
IL
KRAGLRHRKSYQSRHTYACWSL
A
AGANP
S
FIASQMGH
T
N
AQMVFNVYGAWM
K
D
NN
HE
Q
IE
LLN
KR
LSE
S
V
P
C
MPH
fig|344601.5.peg.5198
Escherichia coli B171 (97-424/428)
IEI
CA
NALNRYQSVIKNMLP
M
L
G
E
K
K
L
V
SSITKEDLL
F
A
R
R
DLLTGYQ
KL
S
NGKIS
S
I
KGRSVVTVNYYMTT
I
AGMFQFA
T
DNGY
T
SG
NPFNG
L
A
PLK
K
S
K
VK
PDPLTRDEFIR
F
I
E
ACRHQQTKNLW
I
L
AVYTGIRHGEL
V
S
LAWEDIDLKA
R
TITIRRN
Y
TK
L
G
E
FT
P
PKT
D
AGT
G
R
T
IHL
V
Q
PAIDALKSQA
E
M
T
M
L
G
KQH
S
V
E
V
K
Q
REYGR
S
TV
HKCTFVF
S
PQV
IK
Q
RQFS
G
P
HY
K
VDSIR
ES
W
T
S
IL
KRAGLRHRKSYQSRHTYACWSL
A
AGANP
S
FIASQMGH
T
N
AQMVFNVYGAWM
K
D
NN
HE
Q
IE
LLN
KR
LSE
S
V
P
C
MPH
fig|340185.3.peg.556
Escherichia coli E22 (97-424/428)
IEI
CA
NALNRYQSVIKNMLP
M
L
G
E
K
K
L
V
SSITKEDLL
F
A
R
R
DLLTGYQ
KL
S
NGKTS
S
I
KGRSVVTVNYYMTT
I
AGMFQFA
T
DNGY
T
SG
NPFNG
L
A
PLK
K
S
K
VK
PDPLTRDEFIR
F
I
E
ACRHQQTKNLW
I
L
AVYTGIRHGEL
V
S
LAWEDIDLKA
R
TITIRRN
Y
TK
L
G
E
FT
P
PKT
D
AGT
G
R
T
IHL
V
Q
PAIDALKSQA
E
M
T
M
L
G
KQH
S
V
E
V
K
Q
REYGRT
AV
HKCTFVF
S
PQV
TK
Q
QQLS
G
P
HY
K
VDSIR
ES
W
T
S
IL
KRAGLRHRKSYQSRHTYACWSL
A
AGANP
S
FIASQMGH
T
N
AQMVFNVYGAWM
K
D
NN
HE
Q
IE
LLN
KR
LSE
S
V
P
C
MPH
fig|340185.4.peg.597
Escherichia coli E22 (97-424/428)
IEI
CA
NALNRYQSVIKNMLP
M
L
G
E
K
K
L
V
SSITKEDLL
F
A
R
R
DLLTGYQ
KL
S
NGKTS
S
I
KGRSVVTVNYYMTT
I
AGMFQFA
T
DNGY
T
SG
NPFNG
L
A
PLK
K
S
K
VK
PDPLTRDEFIR
F
I
E
ACRHQQTKNLW
I
L
AVYTGIRHGEL
V
S
LAWEDIDLKA
R
TITIRRN
Y
TK
L
G
E
FT
P
PKT
D
AGT
G
R
T
IHL
V
Q
PAIDALKSQA
E
M
T
M
L
G
KQH
S
V
E
V
K
Q
REYGRT
AV
HKCTFVF
S
PQV
TK
Q
QQLS
G
P
HY
K
VDSIR
ES
W
T
S
IL
KRAGLRHRKSYQSRHTYACWSL
A
AGANP
S
FIASQMGH
T
N
AQMVFNVYGAWM
K
D
NN
HE
Q
IE
LLN
KR
LSE
S
V
P
C
MPH
fig|749548.3.peg.4928
Escherichia coli MS 196-1 (97-424/428)
IEI
CA
NALNRYQSVIKNMLP
M
L
G
E
K
K
L
V
SSITKEDLL
F
A
R
R
DLLTGY
H
KL
S
NGKIS
S
I
KGRSVVTVNYYMTT
I
AGMFQFA
T
DNGY
T
SG
NPFNG
L
A
PLK
K
S
K
VK
PDPLTRDEFIR
F
I
E
ACRHQQTKNLW
I
L
AVYTGIRHGEL
V
S
LAWEDIDLKA
R
TITIRRN
Y
TK
L
G
E
FT
P
PKT
D
AGT
G
R
T
IHL
V
Q
PAIDALKSQA
E
M
T
M
L
G
KQH
S
V
E
V
K
Q
REYGR
S
TV
HKCTFVF
S
PQV
IK
Q
RQFS
G
P
HY
K
VDSIR
ES
W
T
S
IL
KRAGLRHRKSYQSRHTYACWSL
A
AGANP
S
FIASQMGH
T
N
AQMVFNVYGAWM
K
D
NN
HE
Q
IE
LLN
KR
LSE
S
V
P
C
MPH
fig|1040638.4.peg.412
Escherichia coli O104:H4 str. LB226692 (97-428/436)
M
EI
SS
NALNRYQSV
M
KNMLP
R
L
G
P
G
R
LASSITKEDLL
F
I
RKDLLTG
-
E
KG
S
RKTST
S
R
KGR
T
V
P
TVNYYMTT
T
AGMF
S
FA
A
E
NGYL
EK
NPFN
S
I
T
PL
R
K
S
K
PV
PDPLTRDEF
S
RLIDAC
H
HQQTKNLW
T
VAV
F
TG
M
RHGE
I
A
ALAWEDIDLKAGTIT
V
RRN
F
TK
I
G
D
FT
L
PKT
D
AGTNRVIHL
L
A
PAI
E
ALK
N
QA
M
LTRLS
R
QH
Q
I
T
V
Q
LREYGRT
IL
H
E
CTFVF
C
PQ
I
VR
K
NHKA
G
I
N
Y
A
V
S
SI
G
AT
W
D
SAIKRAG
I
R
S
RK
A
YQSRHTYACW
A
L
S
AGANP
T
FIASQMGH
S
S
A
S
MV
Y
NVYGAWM
P
E
CS
VT
QVA
M
LN
NV
L
N
A
R
AP
D
V
P
QS
DQED
fig|6666666.5357.peg.3404
Escherichia coli TY-2482 (97-428/436)
M
EI
SS
NALNRYQSV
M
KNMLP
R
L
G
P
G
R
LASSITKEDLL
F
I
RKDLLTG
-
E
KG
S
RKTST
S
R
KGR
T
V
P
TVNYYMTT
T
AGMF
S
FA
A
E
NGYL
EK
NPFN
S
I
T
PL
R
K
S
K
PV
PDPLTRDEF
S
RLIDAC
H
HQQTKNLW
T
VAV
F
TG
M
RHGE
I
A
ALAWEDIDLKAGTIT
V
RRN
F
TK
I
G
D
FT
L
PKT
D
AGTNRVIHL
L
A
PAI
E
ALK
N
QA
M
LTRLS
R
QH
Q
I
T
V
Q
LREYGRT
IL
H
E
CTFVF
C
PQ
I
VR
K
NHKA
G
I
N
Y
A
V
S
SI
G
AT
W
D
SAIKRAG
I
R
S
RK
A
YQSRHTYACW
A
L
S
AGANP
T
FIASQMGH
S
S
A
S
MV
Y
NVYGAWM
P
E
CS
VT
QVA
M
LN
NV
L
N
A
R
AP
D
V
P
QS
DQED
fig|573235.3.peg.1591
Escherichia coli O26:H11 str. 11368 (97-428/436)
M
EI
SS
NALNRYQSV
M
KNMLP
R
L
G
P
G
R
LASSITKEDLL
F
I
RKDLLTG
-
E
KG
S
RKTST
S
R
KGR
T
V
P
TVNYYMTT
T
AGMF
S
FA
A
E
NGYL
EK
NPFN
S
I
T
PL
R
K
S
K
PV
PDPLTRDEF
S
RLIDAC
H
HQQTKNLW
T
VAV
F
TG
M
RHGE
I
A
ALAWEDIDLKAGTIT
V
RRN
F
TK
I
G
D
FT
L
PKT
D
AGTNRVIHL
L
A
PAI
E
ALK
N
QA
M
LTRLS
R
QH
Q
I
T
V
Q
LREYGRT
IL
H
E
CTFVF
C
PQ
I
VR
K
NHKA
G
I
N
Y
A
V
S
SI
G
AT
W
D
SAIKRAG
I
R
S
RK
A
YQSRHTYACW
A
L
S
AGANP
T
FIASQMGH
S
S
A
S
MV
Y
NVYGAWM
P
E
CS
VT
QVA
M
LN
NV
L
N
A
R
AP
D
V
P
QS
DQED
fig|562.371.peg.1001
Escherichia coli 1044A (97-428/436)
M
EI
GS
NALNRYQSV
M
KNMLP
R
L
G
P
G
R
LASSITKEDLL
F
I
RKDLLTG
-
E
KG
S
RKTST
S
R
KGR
T
V
P
TVNYYMTT
T
AGMF
S
FA
A
E
NGYL
EK
NPFN
S
I
T
PL
R
K
S
K
PV
PDPLTRDEF
S
RLIDAC
H
HQQTKNLW
T
VAV
F
TG
M
RHGE
I
A
ALAWEDIDLKAGTIT
V
RRN
F
TK
I
G
D
FT
L
PKT
D
AGTNRVIHL
L
A
PAI
E
ALK
N
QA
M
LTRLS
R
QH
Q
I
T
V
Q
LREYGRT
IL
H
E
CTFVF
C
PQ
I
VR
K
NHKA
G
I
N
Y
A
V
S
SI
G
AT
W
D
SAIKRAG
I
R
S
RK
A
YQSRHTYACW
A
L
SS
GANP
T
FIASQMGH
S
S
A
S
MV
Y
NVYGAWM
P
E
CS
VT
QVA
M
LN
NV
L
N
A
R
AP
D
V
P
QS
DQED
fig|585396.4.peg.1164
Escherichia coli O111:H- str. 11128 (97-428/436)
M
EI
GS
NALNRYQSV
M
KNMLP
R
L
G
P
G
R
LASSITKEDLL
F
I
RKDLLTG
-
E
KG
S
RKTST
S
R
KGR
T
V
P
TVNYYMTT
T
AGMF
S
FA
A
E
NGYL
EK
NPFN
S
I
T
PL
R
K
S
K
PV
PDPLTRDEF
S
RLIDAC
H
HQQTKNLW
T
VAV
F
TG
M
RHGE
I
A
ALAWEDIDLKAGTIT
V
RRN
F
TK
I
G
D
FT
L
PKT
D
AGTNRVIHL
L
A
PAI
E
ALK
N
QA
M
LTRLS
R
QH
Q
I
T
V
Q
LREYGRT
IL
H
E
CTFVF
C
PQ
I
VR
K
NHKA
G
I
N
Y
A
V
S
SI
G
AT
W
D
SAIKRAG
I
R
S
RK
A
YQSRHTYACW
A
L
SS
GANP
T
FIASQMGH
S
S
A
S
MV
Y
NVYGAWM
P
E
CS
VT
QVA
M
LN
NV
L
N
A
R
AP
D
V
P
QS
DQED
fig|83334.1.peg.1217
Escherichia coli O157:H7 (97-428/436)
M
EI
GS
NALNRYQSV
M
KNMLP
R
L
G
P
G
R
LASSITKEDLL
F
I
RKDLLTG
-
E
KG
S
RKTST
S
R
KGR
T
V
P
TVNYYMTT
T
AGMF
S
FA
A
E
NGYL
EK
NPFN
S
I
T
PL
R
K
S
K
PV
PDPLTRDEF
S
RLIDAC
H
HQQTKNLW
T
VAV
F
TG
M
RHGE
I
A
ALAWEDIDLKAGTIT
V
RRN
F
TK
I
G
D
FT
L
PKT
D
AGTNRVIHL
L
A
PAI
E
ALK
N
QA
M
LTRLS
R
QH
Q
I
T
V
Q
LREYGRT
IL
H
E
CTFVF
C
PQ
I
VR
K
NHKA
G
I
N
Y
A
V
S
SI
G
AT
W
D
SAIKRAG
I
R
S
RK
A
YQSRHTYACW
A
L
SS
GANP
T
FIASQMGH
S
S
A
S
MV
Y
NVYGAWM
P
E
CS
VT
QVA
M
LN
NV
L
N
A
R
AP
D
V
P
QS
DQED
fig|155864.1.peg.1250
Escherichia coli O157:H7 EDL933 (105-436/444)
M
EI
GS
NALNRYQSV
M
KNMLP
R
L
G
P
G
R
LASSITKEDLL
F
I
RKDLLTG
-
E
KG
S
RKTST
S
R
KGR
T
V
P
TVNYYMTT
T
AGMF
S
FA
A
E
NGYL
EK
NPFN
S
I
T
PL
R
K
S
K
PV
PDPLTRDEF
S
RLIDAC
H
HQQTKNLW
T
VAV
F
TG
M
RHGE
I
A
ALAWEDIDLKAGTIT
V
RRN
F
TK
I
G
D
FT
L
PKT
D
AGTNRVIHL
L
A
PAI
E
ALK
N
QA
M
LTRLS
R
QH
Q
I
T
V
Q
LREYGRT
IL
H
E
CTFVF
C
PQ
I
VR
K
NHKA
G
I
N
Y
A
V
S
SI
G
AT
W
D
SAIKRAG
I
R
S
RK
A
YQSRHTYACW
A
L
SS
GANP
T
FIASQMGH
S
S
A
S
MV
Y
NVYGAWM
P
E
CS
VT
QVA
M
LN
NV
L
N
A
R
AP
D
V
P
QS
DQED
fig|155864.8.peg.5371
Escherichia coli O157:H7 EDL933 (97-428/436)
M
EI
GS
NALNRYQSV
M
KNMLP
R
L
G
P
G
R
LASSITKEDLL
F
I
RKDLLTG
-
E
KG
S
RKTST
S
R
KGR
T
V
P
TVNYYMTT
T
AGMF
S
FA
A
E
NGYL
EK
NPFN
S
I
T
PL
R
K
S
K
PV
PDPLTRDEF
S
RLIDAC
H
HQQTKNLW
T
VAV
F
TG
M
RHGE
I
A
ALAWEDIDLKAGTIT
V
RRN
F
TK
I
G
D
FT
L
PKT
D
AGTNRVIHL
L
A
PAI
E
ALK
N
QA
M
LTRLS
R
QH
Q
I
T
V
Q
LREYGRT
IL
H
E
CTFVF
C
PQ
I
VR
K
NHKA
G
I
N
Y
A
V
S
SI
G
AT
W
D
SAIKRAG
I
R
S
RK
A
YQSRHTYACW
A
L
SS
GANP
T
FIASQMGH
S
S
A
S
MV
Y
NVYGAWM
P
E
CS
VT
QVA
M
LN
NV
L
N
A
R
AP
D
V
P
QS
DQED
fig|478006.5.peg.3652
Escherichia coli O157:H7 str. EC4501 (97-428/436)
M
EI
GS
NALNRYQSV
M
KNMLP
R
L
G
P
G
R
LASSITKEDLL
F
I
RKDLLTG
-
E
KG
S
RKTST
S
R
KGR
T
V
P
TVNYYMTT
T
AGMF
S
FA
A
E
NGYL
EK
NPFN
S
I
T
PL
R
K
S
K
PV
PDPLTRDEF
S
RLIDAC
H
HQQTKNLW
T
VAV
F
TG
M
RHGE
I
A
ALAWEDIDLKAGTIT
V
RRN
F
TK
I
G
D
FT
L
PKT
D
AGTNRVIHL
L
A
PAI
E
ALK
N
QA
M
LTRLS
R
QH
Q
I
T
V
Q
LREYGRT
IL
H
E
CTFVF
C
PQ
I
VR
K
NHKA
G
I
N
Y
A
V
S
SI
G
AT
W
D
SAIKRAG
I
R
S
RK
A
YQSRHTYACW
A
L
SS
GANP
T
FIASQMGH
S
S
A
S
MV
Y
NVYGAWM
P
E
CS
VT
QVA
M
LN
NV
L
N
A
R
AP
D
V
P
QS
DQED
fig|386585.9.peg.1278
Escherichia coli O157:H7 str. Sakai (97-428/436)
M
EI
GS
NALNRYQSV
M
KNMLP
R
L
G
P
G
R
LASSITKEDLL
F
I
RKDLLTG
-
E
KG
S
RKTST
S
R
KGR
T
V
P
TVNYYMTT
T
AGMF
S
FA
A
E
NGYL
EK
NPFN
S
I
T
PL
R
K
S
K
PV
PDPLTRDEF
S
RLIDAC
H
HQQTKNLW
T
VAV
F
TG
M
RHGE
I
A
ALAWEDIDLKAGTIT
V
RRN
F
TK
I
G
D
FT
L
PKT
D
AGTNRVIHL
L
A
PAI
E
ALK
N
QA
M
LTRLS
R
QH
Q
I
T
V
Q
LREYGRT
IL
H
E
CTFVF
C
PQ
I
VR
K
NHKA
G
I
N
Y
A
V
S
SI
G
AT
W
D
SAIKRAG
I
R
S
RK
A
YQSRHTYACW
A
L
SS
GANP
T
FIASQMGH
S
S
A
S
MV
Y
NVYGAWM
P
E
CS
VT
QVA
M
LN
NV
L
N
A
R
AP
D
V
P
QS
DQED
fig|502346.5.peg.11
Escherichia coli O157:H7 str. TW14588 (97-428/436)
M
EI
GS
NALNRYQSV
M
KNMLP
R
L
G
P
G
R
LASSITKEDLL
F
I
RKDLLTG
-
E
KG
S
RKTST
S
R
KGR
T
V
P
TVNYYMTT
T
AGMF
S
FA
A
E
NGYL
EK
NPFN
S
I
T
PL
R
K
S
K
PV
PDPLTRDEF
S
RLIDAC
H
HQQTKNLW
T
VAV
F
TG
M
RHGE
I
A
ALAWEDIDLKAGTIT
V
RRN
F
TK
I
G
D
FT
L
PKT
D
AGTNRVIHL
L
A
PAI
E
ALK
N
QA
M
LTRLS
R
QH
Q
I
T
V
Q
LREYGRT
IL
H
E
CTFVF
C
PQ
I
VR
K
NHKA
G
I
N
Y
A
V
S
SI
G
AT
W
D
SAIKRAG
I
R
S
RK
A
YQSRHTYACW
A
L
SS
GANP
T
FIASQMGH
S
S
A
S
MV
Y
NVYGAWM
P
E
CS
VT
QVA
M
LN
NV
L
N
A
R
AP
D
V
P
QS
DQED
fig|585397.7.peg.1096
Escherichia coli ED1a (97-428/436)
M
EI
SS
NALNRYQSV
M
KNMLP
R
L
G
V
G
R
LASSITKEDLL
F
I
RKDLLTG
-
E
KE
S
RKNTS
T
N
KGR
T
V
P
TVNYYMTT
T
AGMF
S
FA
A
E
NGYL
EK
NPFN
S
I
T
PL
R
K
S
K
PV
PDPLTR
E
EF
G
RLIDAC
H
HQQTKNLW
T
VAV
F
TG
M
RHGE
I
A
ALAWEDIDLK
V
GTIT
V
RRN
F
TK
I
G
D
FT
L
PKT
D
AGT
D
RVIHL
L
A
PAI
E
ALK
N
QA
M
LTRL
GR
QH
Q
I
T
V
K
LREYGRT
IL
H
E
CTFVF
C
PQ
I
VR
K
NHKA
G
I
N
Y
A
V
S
SI
G
AT
W
D
SA
M
KRAG
I
R
A
RK
A
YQSRHTYACW
A
L
S
AGANP
T
FIASQMGH
S
S
A
S
MV
Y
NVYGAWM
P
E
CS
VT
QVA
M
LN
NV
L
N
A
R
AP
D
V
P
QS
DQED
fig|585397.9.peg.1095
Escherichia coli ED1a (97-428/436)
M
EI
SS
NALNRYQSV
M
KNMLP
R
L
G
V
G
R
LASSITKEDLL
F
I
RKDLLTG
-
E
KE
S
RKNTS
T
N
KGR
T
V
P
TVNYYMTT
T
AGMF
S
FA
A
E
NGYL
EK
NPFN
S
I
T
PL
R
K
S
K
PV
PDPLTR
E
EF
G
RLIDAC
H
HQQTKNLW
T
VAV
F
TG
M
RHGE
I
A
ALAWEDIDLK
V
GTIT
V
RRN
F
TK
I
G
D
FT
L
PKT
D
AGT
D
RVIHL
L
A
PAI
E
ALK
N
QA
M
LTRL
GR
QH
Q
I
T
V
K
LREYGRT
IL
H
E
CTFVF
C
PQ
I
VR
K
NHKA
G
I
N
Y
A
V
S
SI
G
AT
W
D
SA
M
KRAG
I
R
A
RK
A
YQSRHTYACW
A
L
S
AGANP
T
FIASQMGH
S
S
A
S
MV
Y
NVYGAWM
P
E
CS
VT
QVA
M
LN
NV
L
N
A
R
AP
D
V
P
QS
DQED
fig|340184.3.peg.1023
Escherichia coli B7A (100-426/431)
E
V
AK
TS
LN
T
Y
RA
VIKN
I
L
S
I
IG
E
K
N
LASSI
N
KE
K
LL
E
VRK
E
LLTGYQ
IP
K
SNYIV
T
Q
P
GRS
A
VTVN
N
YMT
N
L
NAV
FQF
G
V
DNGYL
AD
NPF
K
GISPLKESR
TI
PDPL
S
R
E
EFIRLIDACR
N
QQ
A
KNLW
C
V
S
VYTG
V
R
P
GEL
C
AL
G
WEDIDLK
N
GT
MM
IRRN
L
A
K
-
D
R
FT
V
PKTQAGTNRVIHLI
K
PAIDAL
R
SQ
M
T
LTRLSK
E
H
I
I
D
V
H
LREYGRT
EK
HKCTFVF
Q
P
E
V
SA
R
VKNY
G
D
H
F
T
VDSIR
QM
W
D
A
AIKRAGLRHRKSYQSRHTYACWSLTAGANPAFIA
N
QMGHADAQMVF
Q
VYG
K
WM
S
ENN
NA
QVALLN
TQ
LSE
F
AP
T
MPHN
fig|340184.6.peg.1058
Escherichia coli B7A (95-421/426)
E
V
AK
TS
LN
T
Y
RA
VIKN
I
L
S
I
IG
E
K
N
LASSI
N
KE
K
LL
E
VRK
E
LLTGYQ
IP
K
SNYIV
T
Q
P
GRS
A
VTVN
N
YMT
N
L
NAV
FQF
G
V
DNGYL
AD
NPF
K
GISPLKESR
TI
PDPL
S
R
E
EFIRLIDACR
N
QQ
A
KNLW
C
V
S
VYTG
V
R
P
GEL
C
AL
G
WEDIDLK
N
GT
MM
IRRN
L
A
K
-
D
R
FT
V
PKTQAGTNRVIHLI
K
PAIDAL
R
SQ
M
T
LTRLSK
E
H
I
I
D
V
H
LREYGRT
EK
HKCTFVF
Q
P
E
V
SA
R
VKNY
G
D
H
F
T
VDSIR
QM
W
D
A
AIKRAGLRHRKSYQSRHTYACWSLTAGANPAFIA
N
QMGHADAQMVF
Q
VYG
K
WM
S
ENN
NA
QVALLN
TQ
LSE
F
AP
T
MPHN
fig|749532.3.peg.1345
Escherichia coli MS 78-1 (95-421/426)
E
V
AK
TS
LN
T
Y
RA
VIKN
I
L
S
I
IG
E
K
N
LASSI
N
KE
K
LL
E
VRK
E
LLTGYQ
IP
K
SNYIV
T
Q
P
GRS
A
VTVN
N
YMT
N
L
NAV
FQF
G
V
DNGYL
AD
NPF
K
GISPLKESR
TI
PDPL
S
R
E
EFIRLIDACR
N
QQ
A
KNLW
C
V
S
VYTG
V
R
P
GEL
C
AL
G
WEDIDLK
N
GT
MM
IRRN
L
A
K
-
D
R
FT
V
PKTQAGTNRVIHLI
K
PAIDAL
R
SQ
M
T
LTRLSK
E
H
I
I
D
V
H
LREYGRT
EK
HKCTFVF
Q
P
E
V
SA
R
VKNY
G
D
H
F
T
VDSIR
QM
W
D
A
AIKRAGLRHRKSYQSRHTYACWSLTAGANPAFIA
N
QMGHADAQMVF
Q
VYG
K
WM
S
ENN
NA
QVALLN
TQ
LSE
F
AP
T
MPHN
fig|656393.3.peg.2365
Escherichia coli H299 (95-421/426)
E
V
AK
TS
LN
T
Y
RA
VIKN
I
L
S
I
IG
E
K
N
LASSI
N
KE
K
LL
E
VRK
E
LLTGYQ
IP
K
SNYIV
T
Q
P
GRS
A
VTVN
N
YMT
N
L
NAV
FQF
G
V
DNGYL
AD
NPF
K
GISPLKESR
TI
PDPL
S
R
E
EFIRLIDACR
N
QQ
A
KNLW
C
V
S
VYTG
V
R
P
GEL
C
AL
G
WEDIDLK
N
GT
MM
IRRN
L
A
K
-
D
R
FT
V
PKTQAGTNRVIHLI
K
PAIDAL
R
SQ
M
T
LTRLSK
E
H
I
I
D
V
Y
LREYGRT
EK
HKCTFVF
Q
P
E
V
SA
R
VKNY
G
D
H
F
T
VDSIR
QM
W
D
A
AIKRAGLRHRKSYQSRHTYACWSLTAGANPAFIA
N
QMGHADAQMVF
Q
VYG
K
WM
S
ENN
NA
QVALLN
TQ
LSE
F
AP
T
MPHN
fig|481805.3.peg.2209
Escherichia coli ATCC 8739 (100-426/431)
E
V
AK
TS
LN
T
Y
RA
VIKN
I
L
S
I
IG
E
K
N
LASSI
N
KE
K
LL
E
VRK
E
LLTGYQ
IP
K
SNYIV
T
Q
P
GRS
A
VTVN
N
YMT
N
L
NAV
FQF
G
V
DNGYL
AD
NPF
K
GISPLKESR
TI
PDPL
S
R
E
EFIRLIDACR
N
QQ
A
KNLW
C
V
S
VYTG
V
R
P
GEL
C
AL
G
WEDIDLK
N
GT
MM
IRRN
L
A
K
-
D
R
FT
V
PKTQAGTNRVIHLI
K
PAIDAL
R
SQ
M
T
LTRLSK
E
H
I
I
D
V
H
LREYGRT
EK
Q
KCTFVF
Q
P
E
V
SA
R
VKNY
G
D
H
F
T
VDSIR
QM
W
D
A
AIKRAGLRHRKSYQSRHTYACWSLTAGANPAFIA
N
QMGHADAQMVF
Q
VYG
K
WM
S
ENN
NA
QVALLN
TQ
LSE
Y
AP
T
MPHN
fig|481805.6.peg.2202
Escherichia coli ATCC 8739 (95-421/426)
E
V
AK
TS
LN
T
Y
RA
VIKN
I
L
S
I
IG
E
K
N
LASSI
N
KE
K
LL
E
VRK
E
LLTGYQ
IP
K
SNYIV
T
Q
P
GRS
A
VTVN
N
YMT
N
L
NAV
FQF
G
V
DNGYL
AD
NPF
K
GISPLKESR
TI
PDPL
S
R
E
EFIRLIDACR
N
QQ
A
KNLW
C
V
S
VYTG
V
R
P
GEL
C
AL
G
WEDIDLK
N
GT
MM
IRRN
L
A
K
-
D
R
FT
V
PKTQAGTNRVIHLI
K
PAIDAL
R
SQ
M
T
LTRLSK
E
H
I
I
D
V
H
LREYGRT
EK
Q
KCTFVF
Q
P
E
V
SA
R
VKNY
G
D
H
F
T
VDSIR
QM
W
D
A
AIKRAGLRHRKSYQSRHTYACWSLTAGANPAFIA
N
QMGHADAQMVF
Q
VYG
K
WM
S
ENN
NA
QVALLN
TQ
LSE
Y
AP
T
MPHN
fig|679204.3.peg.494
Escherichia coli MS 145-7 (95-421/426)
E
V
AK
TS
LN
T
Y
RA
VIKN
I
L
S
I
IG
E
K
N
LASSI
N
KE
K
LL
E
VRK
E
LLTGYQ
IP
K
SNYIV
T
Q
P
GRS
A
VTVN
N
YMT
N
L
NAV
FQF
G
V
DNGYL
AD
NPF
K
GISPLKESR
SI
PDPL
S
R
E
EFIRLIDACR
N
QQ
A
KNLW
C
V
S
VYTG
V
R
P
GEL
C
AL
G
WEDIDLK
N
GT
MM
IRRN
L
A
K
-
D
R
FT
V
PKTQAGTNRVIHLI
K
PAIDAL
R
SQ
M
T
LTRLSK
E
H
I
I
D
V
H
LREYGRT
EK
Q
KCTFVF
Q
P
E
V
SA
R
VKNY
G
D
H
F
T
VDSIR
QM
W
D
A
AIKRAGLRHRKSYQSRHTYACWSLTAGANPAFIA
N
QMGHADAQMVF
Q
VYG
K
WM
S
ENN
NA
QVALLN
TQ
LSE
F
AP
T
MPHN
fig|216592.1.peg.2161
Escherichia coli 042 (100-426/431)
E
V
AK
TS
LN
T
Y
RA
VIKN
I
L
S
I
IG
E
K
N
LASSI
N
KE
K
LL
E
VRK
E
LLTGYQ
IP
K
SNYIV
T
Q
P
GRS
A
VTVN
N
YMT
N
L
NAV
FQF
G
V
DNGYL
AD
NPF
K
GISPLKESR
TI
PDPL
S
R
E
EFIRLIDACR
N
QQ
A
KNLW
C
V
S
VYTG
V
R
P
GEL
C
AL
G
WEDIDLK
N
GT
MM
IRRN
L
A
K
-
D
R
FT
V
PKTQAGTNRVIHLI
K
PAIDAL
R
SQ
M
T
LTRLSK
E
H
I
I
D
V
H
LREYGRT
EK
Q
KCTFVF
Q
P
E
V
SA
R
VKNY
G
D
H
F
T
VDSIR
QM
W
D
A
AIKRAGLRHRKSYQSRHTYACWSLTAGANPAFIA
N
QMGHADAQMVF
Q
VYG
K
WM
S
ENN
NA
QVALLN
TQ
LSE
F
AP
T
MPHN
fig|216592.3.peg.1797
Escherichia coli 042 (95-421/426)
E
V
AK
TS
LN
T
Y
RA
VIKN
I
L
S
I
IG
E
K
N
LASSI
N
KE
K
LL
E
VRK
E
LLTGYQ
IP
K
SNYIV
T
Q
P
GRS
A
VTVN
N
YMT
N
L
NAV
FQF
G
V
DNGYL
AD
NPF
K
GISPLKESR
TI
PDPL
S
R
E
EFIRLIDACR
N
QQ
A
KNLW
C
V
S
VYTG
V
R
P
GEL
C
AL
G
WEDIDLK
N
GT
MM
IRRN
L
A
K
-
D
R
FT
V
PKTQAGTNRVIHLI
K
PAIDAL
R
SQ
M
T
LTRLSK
E
H
I
I
D
V
H
LREYGRT
EK
Q
KCTFVF
Q
P
E
V
SA
R
VKNY
G
D
H
F
T
VDSIR
QM
W
D
A
AIKRAGLRHRKSYQSRHTYACWSLTAGANPAFIA
N
QMGHADAQMVF
Q
VYG
K
WM
S
ENN
NA
QVALLN
TQ
LSE
F
AP
T
MPHN
fig|585055.6.peg.1772
Escherichia coli 55989 (95-421/426)
E
V
AK
TS
LN
T
Y
RA
VIKN
I
L
S
I
IG
E
K
N
LASSI
N
KE
K
LL
E
VRK
E
LLTGYQ
IP
K
SNYIV
T
Q
P
GRS
A
VTVN
N
YMT
N
L
NAV
FQF
G
V
DNGYL
AD
NPF
K
GISPLKESR
TI
PDPL
S
R
E
EFIRLIDACR
N
QQ
A
KNLW
C
V
S
VYTG
V
R
P
GEL
C
AL
G
WEDIDLK
N
GT
MM
IRRN
L
A
K
-
D
R
FT
V
PKTQAGTNRVIHLI
K
PAIDAL
R
SQ
M
T
LTRLSK
E
H
I
I
D
V
H
LREYGRT
EK
Q
KCTFVF
Q
P
E
V
SA
R
VKNY
G
D
H
F
T
VDSIR
QM
W
D
A
AIKRAGLRHRKSYQSRHTYACWSLTAGANPAFIA
N
QMGHADAQMVF
Q
VYG
K
WM
S
ENN
NA
QVALLN
TQ
LSE
F
AP
T
MPHN
fig|585055.8.peg.1776
Escherichia coli 55989 (95-421/426)
E
V
AK
TS
LN
T
Y
RA
VIKN
I
L
S
I
IG
E
K
N
LASSI
N
KE
K
LL
E
VRK
E
LLTGYQ
IP
K
SNYIV
T
Q
P
GRS
A
VTVN
N
YMT
N
L
NAV
FQF
G
V
DNGYL
AD
NPF
K
GISPLKESR
TI
PDPL
S
R
E
EFIRLIDACR
N
QQ
A
KNLW
C
V
S
VYTG
V
R
P
GEL
C
AL
G
WEDIDLK
N
GT
MM
IRRN
L
A
K
-
D
R
FT
V
PKTQAGTNRVIHLI
K
PAIDAL
R
SQ
M
T
LTRLSK
E
H
I
I
D
V
H
LREYGRT
EK
Q
KCTFVF
Q
P
E
V
SA
R
VKNY
G
D
H
F
T
VDSIR
QM
W
D
A
AIKRAGLRHRKSYQSRHTYACWSLTAGANPAFIA
N
QMGHADAQMVF
Q
VYG
K
WM
S
ENN
NA
QVALLN
TQ
LSE
F
AP
T
MPHN
fig|595496.3.peg.1539
Escherichia coli BW2952 (67-393/398)
E
V
AK
TS
LN
T
Y
RA
VIKN
I
L
S
I
IG
E
K
N
LASSI
N
KE
K
LL
E
VRK
E
LLTGYQ
IP
K
SNYIV
T
Q
P
GRS
A
VTVN
N
YMT
N
L
NAV
FQF
G
V
DNGYL
AD
NPF
K
GISPLKESR
TI
PDPL
S
R
E
EFIRLIDACR
N
QQ
A
KNLW
C
V
S
VYTG
V
R
P
GEL
C
AL
G
WEDIDLK
N
GT
MM
IRRN
L
A
K
-
D
R
FT
V
PKTQAGTNRVIHLI
K
PAIDAL
R
SQ
M
T
LTRLSK
E
H
I
I
D
V
H
LREYGRT
EK
Q
KCTFVF
Q
P
E
V
SA
R
VKNY
G
D
H
F
T
VDSIR
QM
W
D
A
AIKRAGLRHRKSYQSRHTYACWSLTAGANPAFIA
N
QMGHADAQMVF
Q
VYG
K
WM
S
ENN
NA
QVALLN
TQ
LSE
F
AP
T
MPHN
fig|536056.3.peg.2175
Escherichia coli DH1 (67-393/398)
E
V
AK
TS
LN
T
Y
RA
VIKN
I
L
S
I
IG
E
K
N
LASSI
N
KE
K
LL
E
VRK
E
LLTGYQ
IP
K
SNYIV
T
Q
P
GRS
A
VTVN
N
YMT
N
L
NAV
FQF
G
V
DNGYL
AD
NPF
K
GISPLKESR
TI
PDPL
S
R
E
EFIRLIDACR
N
QQ
A
KNLW
C
V
S
VYTG
V
R
P
GEL
C
AL
G
WEDIDLK
N
GT
MM
IRRN
L
A
K
-
D
R
FT
V
PKTQAGTNRVIHLI
K
PAIDAL
R
SQ
M
T
LTRLSK
E
H
I
I
D
V
H
LREYGRT
EK
Q
KCTFVF
Q
P
E
V
SA
R
VKNY
G
D
H
F
T
VDSIR
QM
W
D
A
AIKRAGLRHRKSYQSRHTYACWSLTAGANPAFIA
N
QMGHADAQMVF
Q
VYG
K
WM
S
ENN
NA
QVALLN
TQ
LSE
F
AP
T
MPHN
fig|562.375.peg.1676
Escherichia coli EC4100B (95-421/426)
E
V
AK
TS
LN
T
Y
RA
VIKN
I
L
S
I
IG
E
K
N
LASSI
N
KE
K
LL
E
VRK
E
LLTGYQ
IP
K
SNYIV
T
Q
P
GRS
A
VTVN
N
YMT
N
L
NAV
FQF
G
V
DNGYL
AD
NPF
K
GISPLKESR
TI
PDPL
S
R
E
EFIRLIDACR
N
QQ
A
KNLW
C
V
S
VYTG
V
R
P
GEL
C
AL
G
WEDIDLK
N
GT
MM
IRRN
L
A
K
-
D
R
FT
V
PKTQAGTNRVIHLI
K
PAIDAL
R
SQ
M
T
LTRLSK
E
H
I
I
D
V
H
LREYGRT
EK
Q
KCTFVF
Q
P
E
V
SA
R
VKNY
G
D
H
F
T
VDSIR
QM
W
D
A
AIKRAGLRHRKSYQSRHTYACWSLTAGANPAFIA
N
QMGHADAQMVF
Q
VYG
K
WM
S
ENN
NA
QVALLN
TQ
LSE
F
AP
T
MPHN
fig|656414.3.peg.1879
Escherichia coli H736 (95-421/426)
E
V
AK
TS
LN
T
Y
RA
VIKN
I
L
S
I
IG
E
K
N
LASSI
N
KE
K
LL
E
VRK
E
LLTGYQ
IP
K
SNYIV
T
Q
P
GRS
A
VTVN
N
YMT
N
L
NAV
FQF
G
V
DNGYL
AD
NPF
K
GISPLKESR
TI
PDPL
S
R
E
EFIRLIDACR
N
QQ
A
KNLW
C
V
S
VYTG
V
R
P
GEL
C
AL
G
WEDIDLK
N
GT
MM
IRRN
L
A
K
-
D
R
FT
V
PKTQAGTNRVIHLI
K
PAIDAL
R
SQ
M
T
LTRLSK
E
H
I
I
D
V
H
LREYGRT
EK
Q
KCTFVF
Q
P
E
V
SA
R
VKNY
G
D
H
F
T
VDSIR
QM
W
D
A
AIKRAGLRHRKSYQSRHTYACWSLTAGANPAFIA
N
QMGHADAQMVF
Q
VYG
K
WM
S
ENN
NA
QVALLN
TQ
LSE
F
AP
T
MPHN
fig|585057.4.peg.1545
Escherichia coli IAI39 (95-421/426)
E
V
AK
TS
LN
T
Y
RA
VIKN
I
L
S
I
IG
E
K
N
LASSI
N
KE
K
LL
E
VRK
E
LLTGYQ
IP
K
SNYIV
T
Q
P
GRS
A
VTVN
N
YMT
N
L
NAV
FQF
G
V
DNGYL
AD
NPF
K
GISPLKESR
TI
PDPL
S
R
E
EFIRLIDACR
N
QQ
A
KNLW
C
V
S
VYTG
V
R
P
GEL
C
AL
G
WEDIDLK
N
GT
MM
IRRN
L
A
K
-
D
R
FT
V
PKTQAGTNRVIHLI
K
PAIDAL
R
SQ
M
T
LTRLSK
E
H
I
I
D
V
H
LREYGRT
EK
Q
KCTFVF
Q
P
E
V
SA
R
VKNY
G
D
H
F
T
VDSIR
QM
W
D
A
AIKRAGLRHRKSYQSRHTYACWSLTAGANPAFIA
N
QMGHADAQMVF
Q
VYG
K
WM
S
ENN
NA
QVALLN
TQ
LSE
F
AP
T
MPHN
fig|585057.6.peg.1545
Escherichia coli IAI39 (95-421/426)
E
V
AK
TS
LN
T
Y
RA
VIKN
I
L
S
I
IG
E
K
N
LASSI
N
KE
K
LL
E
VRK
E
LLTGYQ
IP
K
SNYIV
T
Q
P
GRS
A
VTVN
N
YMT
N
L
NAV
FQF
G
V
DNGYL
AD
NPF
K
GISPLKESR
TI
PDPL
S
R
E
EFIRLIDACR
N
QQ
A
KNLW
C
V
S
VYTG
V
R
P
GEL
C
AL
G
WEDIDLK
N
GT
MM
IRRN
L
A
K
-
D
R
FT
V
PKTQAGTNRVIHLI
K
PAIDAL
R
SQ
M
T
LTRLSK
E
H
I
I
D
V
H
LREYGRT
EK
Q
KCTFVF
Q
P
E
V
SA
R
VKNY
G
D
H
F
T
VDSIR
QM
W
D
A
AIKRAGLRHRKSYQSRHTYACWSLTAGANPAFIA
N
QMGHADAQMVF
Q
VYG
K
WM
S
ENN
NA
QVALLN
TQ
LSE
F
AP
T
MPHN
fig|679206.4.peg.1328
Escherichia coli MS 119-7 (95-421/426)
E
V
AK
TS
LN
T
Y
RA
VIKN
I
L
S
I
IG
E
K
N
LASSI
N
KE
K
LL
E
VRK
E
LLTGYQ
IP
K
SNYIV
T
Q
P
GRS
A
VTVN
N
YMT
N
L
NAV
FQF
G
V
DNGYL
AD
NPF
K
GISPLKESR
TI
PDPL
S
R
E
EFIRLIDACR
N
QQ
A
KNLW
C
V
S
VYTG
V
R
P
GEL
C
AL
G
WEDIDLK
N
GT
MM
IRRN
L
A
K
-
D
R
FT
V
PKTQAGTNRVIHLI
K
PAIDAL
R
SQ
M
T
LTRLSK
E
H
I
I
D
V
H
LREYGRT
EK
Q
KCTFVF
Q
P
E
V
SA
R
VKNY
G
D
H
F
T
VDSIR
QM
W
D
A
AIKRAGLRHRKSYQSRHTYACWSLTAGANPAFIA
N
QMGHADAQMVF
Q
VYG
K
WM
S
ENN
NA
QVALLN
TQ
LSE
F
AP
T
MPHN
fig|749540.3.peg.4210
Escherichia coli MS 146-1 (95-421/426)
E
V
AK
TS
LN
T
Y
RA
VIKN
I
L
S
I
IG
E
K
N
LASSI
N
KE
K
LL
E
VRK
E
LLTGYQ
IP
K
SNYIV
T
Q
P
GRS
A
VTVN
N
YMT
N
L
NAV
FQF
G
V
DNGYL
AD
NPF
K
GISPLKESR
TI
PDPL
S
R
E
EFIRLIDACR
N
QQ
A
KNLW
C
V
S
VYTG
V
R
P
GEL
C
AL
G
WEDIDLK
N
GT
MM
IRRN
L
A
K
-
D
R
FT
V
PKTQAGTNRVIHLI
K
PAIDAL
R
SQ
M
T
LTRLSK
E
H
I
I
D
V
H
LREYGRT
EK
Q
KCTFVF
Q
P
E
V
SA
R
VKNY
G
D
H
F
T
VDSIR
QM
W
D
A
AIKRAGLRHRKSYQSRHTYACWSLTAGANPAFIA
N
QMGHADAQMVF
Q
VYG
K
WM
S
ENN
NA
QVALLN
TQ
LSE
F
AP
T
MPHN
fig|749527.3.peg.4310
Escherichia coli MS 21-1 (95-421/426)
E
V
AK
TS
LN
T
Y
RA
VIKN
I
L
S
I
IG
E
K
N
LASSI
N
KE
K
LL
E
VRK
E
LLTGYQ
IP
K
SNYIV
T
Q
P
GRS
A
VTVN
N
YMT
N
L
NAV
FQF
G
V
DNGYL
AD
NPF
K
GISPLKESR
TI
PDPL
S
R
E
EFIRLIDACR
N
QQ
A
KNLW
C
V
S
VYTG
V
R
P
GEL
C
AL
G
WEDIDLK
N
GT
MM
IRRN
L
A
K
-
D
R
FT
V
PKTQAGTNRVIHLI
K
PAIDAL
R
SQ
M
T
LTRLSK
E
H
I
I
D
V
H
LREYGRT
EK
Q
KCTFVF
Q
P
E
V
SA
R
VKNY
G
D
H
F
T
VDSIR
QM
W
D
A
AIKRAGLRHRKSYQSRHTYACWSLTAGANPAFIA
N
QMGHADAQMVF
Q
VYG
K
WM
S
ENN
NA
QVALLN
TQ
LSE
F
AP
T
MPHN
fig|656443.3.peg.2223
Escherichia coli TA271 (95-421/426)
E
V
AK
TS
LN
T
Y
RA
VIKN
I
L
S
I
IG
E
K
N
LASSI
N
KE
K
LL
E
VRK
E
LLTGYQ
IP
K
SNYIV
T
Q
P
GRS
A
VTVN
N
YMT
N
L
NAV
FQF
G
V
DNGYL
AD
NPF
K
GISPLKESR
TI
PDPL
S
R
E
EFIRLIDACR
N
QQ
A
KNLW
C
V
S
VYTG
V
R
P
GEL
C
AL
G
WEDIDLK
N
GT
MM
IRRN
L
A
K
-
D
R
FT
V
PKTQAGTNRVIHLI
K
PAIDAL
R
SQ
M
T
LTRLSK
E
H
I
I
D
V
H
LREYGRT
EK
Q
KCTFVF
Q
P
E
V
SA
R
VKNY
G
D
H
F
T
VDSIR
QM
W
D
A
AIKRAGLRHRKSYQSRHTYACWSLTAGANPAFIA
N
QMGHADAQMVF
Q
VYG
K
WM
S
ENN
NA
QVALLN
TQ
LSE
F
AP
T
MPHN
fig|316407.3.peg.1536
Escherichia coli W3110 (67-393/398)
E
V
AK
TS
LN
T
Y
RA
VIKN
I
L
S
I
IG
E
K
N
LASSI
N
KE
K
LL
E
VRK
E
LLTGYQ
IP
K
SNYIV
T
Q
P
GRS
A
VTVN
N
YMT
N
L
NAV
FQF
G
V
DNGYL
AD
NPF
K
GISPLKESR
TI
PDPL
S
R
E
EFIRLIDACR
N
QQ
A
KNLW
C
V
S
VYTG
V
R
P
GEL
C
AL
G
WEDIDLK
N
GT
MM
IRRN
L
A
K
-
D
R
FT
V
PKTQAGTNRVIHLI
K
PAIDAL
R
SQ
M
T
LTRLSK
E
H
I
I
D
V
H
LREYGRT
EK
Q
KCTFVF
Q
P
E
V
SA
R
VKNY
G
D
H
F
T
VDSIR
QM
W
D
A
AIKRAGLRHRKSYQSRHTYACWSLTAGANPAFIA
N
QMGHADAQMVF
Q
VYG
K
WM
S
ENN
NA
QVALLN
TQ
LSE
F
AP
T
MPHN
fig|331111.12.peg.2073
Escherichia coli E24377A (95-421/426)
E
V
AK
TS
LN
T
Y
RA
VIKN
I
L
S
I
IG
E
K
N
LASSI
N
KE
K
LL
E
VRK
E
LLTGYQ
IP
K
SNYIV
T
Q
P
GRS
A
VTVN
N
YMT
N
L
NAV
FQF
G
V
DNGYL
AD
NPF
K
GISPLKESR
TI
PDPL
S
R
E
EFIRLIDACR
N
QQ
A
KNLW
C
V
S
VYTG
V
R
P
GEL
C
AL
G
WEDIDLK
N
GT
MM
IRRN
L
A
K
-
D
R
FT
V
PKTQAGTNRVIHLI
K
PAIDAL
R
SQ
M
T
LTRLSK
E
H
I
I
D
V
H
LREYGRT
EK
Q
KCTFVF
Q
P
E
V
SA
R
VKNY
G
D
H
F
T
VDSIR
QM
W
D
A
AIKRAGLRHRKSYQSRHTYACWSLTAGANPAFIA
N
QMGHADAQMVF
K
VYG
K
WM
S
ENN
NA
QVALLN
TQ
LSE
F
AP
T
MPHN
fig|331111.3.peg.4216
Escherichia coli E24377A (100-426/431)
E
V
AK
TS
LN
T
Y
RA
VIKN
I
L
S
I
IG
E
K
N
LASSI
N
KE
K
LL
E
VRK
E
LLTGYQ
IP
K
SNYIV
T
Q
P
GRS
A
VTVN
N
YMT
N
L
NAV
FQF
G
V
DNGYL
AD
NPF
K
GISPLKESR
TI
PDPL
S
R
E
EFIRLIDACR
N
QQ
A
KNLW
C
V
S
VYTG
V
R
P
GEL
C
AL
G
WEDIDLK
N
GT
MM
IRRN
L
A
K
-
D
R
FT
V
PKTQAGTNRVIHLI
K
PAIDAL
R
SQ
M
T
LTRLSK
E
H
I
I
D
V
H
LREYGRT
EK
Q
KCTFVF
Q
P
E
V
SA
R
VKNY
G
D
H
F
T
VDSIR
QM
W
D
A
AIKRAGLRHRKSYQSRHTYACWSLTAGANPAFIA
N
QMGHADAQMVF
K
VYG
K
WM
S
ENN
NA
QVALLN
TQ
LSE
F
AP
T
MPHN
fig|679205.4.peg.1607
Escherichia coli MS 124-1 (95-421/426)
E
V
AK
TS
LN
T
Y
RA
VIKN
I
L
S
I
IG
E
K
N
LASSI
N
KE
K
LL
E
VRK
E
LLTGYQ
IP
K
SNYIV
T
Q
P
GRS
A
VTVN
N
YMT
N
L
NAV
FQF
G
V
DNGYL
AD
NPF
K
GISPLKESR
TI
PDPL
S
R
E
EFIRLIDACR
N
QQ
A
KNLW
C
V
S
VYTG
V
R
P
GEL
C
AL
G
WEDIDLK
N
GT
MM
IRRN
L
A
K
-
D
R
FT
V
PKTQAGTNRVIHLI
K
PAIDAL
R
SQ
M
T
LTRLSK
E
H
I
I
D
V
H
LREYGRT
EK
Q
KCTFVF
Q
P
E
V
SA
R
VKNY
G
D
H
F
T
VDSIR
QM
W
D
A
AIKRAGLRHRKSYQSRHTYACWSLTAGANPAFIA
N
QMGHADAQMVF
K
VYG
K
WM
S
ENN
NA
QVALLN
TQ
LSE
F
AP
T
MPHN
fig|749533.3.peg.4949
Escherichia coli MS 84-1 (95-421/426)
E
V
AK
TS
LN
T
Y
RA
VIKN
I
L
S
I
IG
E
K
N
LASSI
N
KE
K
LL
E
VRK
E
LLTGYQ
IP
K
SNYIV
T
Q
P
GRS
A
VTVN
N
YMT
N
L
NAV
FQF
G
V
DNGYL
AD
NPF
K
GISPLKESR
TI
PDPL
S
R
E
EFIRLIDACR
N
QQ
A
KNLW
C
V
S
VYTG
V
R
P
GEL
C
AL
G
WEDIDLK
N
GT
MM
IRRN
L
A
K
-
D
R
FT
V
PKTQAGTNRVIHLI
K
PAIDAL
R
SQ
M
T
LTRLSK
E
H
I
I
D
V
H
LREYGRT
EK
Q
KCTFVF
Q
P
E
V
SA
R
VKNY
G
D
H
F
T
VDSIR
QM
W
D
A
AIKRAGLRHRKSYQSRHTYACWSLTAGANPAFIA
N
QMGHADAQMVF
K
VYG
K
WM
S
ENN
NA
QVALLN
TQ
LSE
F
AP
T
MPHN
fig|685038.3.peg.1594
Escherichia coli O83:H1 str. NRG 857C (95-421/426)
E
V
AK
TS
LN
T
Y
RA
VIKN
I
L
S
I
IG
E
K
N
LASSI
N
KE
K
LL
E
VRK
E
LLTGYQ
IP
K
SNYIV
T
Q
P
GRS
A
VTVN
N
YMT
N
L
NAV
FQF
G
V
DNGYL
PD
NPF
K
GISPLKESR
TI
PDPL
S
R
E
EFIRLIDACR
N
QQ
A
KNLW
C
V
S
VYTG
V
R
P
GEL
C
AL
G
WEDIDLK
N
GT
MM
IRRN
L
A
K
-
D
R
FT
V
PKTQAGTNRVIHLI
K
PAIDAL
R
SQ
M
T
LTRLSK
E
H
I
I
D
V
H
LREYGRT
EK
Q
KCTFVF
Q
P
E
V
SA
R
VKNY
G
D
H
F
T
VDSIR
QM
W
D
A
AIKRAGLRHRKSYQSRHTYACWSLTAGANPAFIA
N
QMGHADAQMVF
Q
VYG
K
WM
S
ENN
NA
QVALLN
TQ
LSE
F
AP
T
MPHN
fig|656444.3.peg.2466
Escherichia coli TA280 (95-421/426)
E
V
AK
TS
LN
T
Y
RA
VIKN
I
L
S
I
IG
E
K
N
LASSI
N
KE
K
LL
E
VRK
E
LLTGYQ
IP
K
SNYIV
T
Q
P
GRS
A
VTVN
N
YMT
N
L
NAV
FQF
G
V
DNGYL
PD
NPF
K
GISPLKESR
TI
PDPL
S
R
E
EFIRLIDACR
N
QQ
A
KNLW
C
V
S
VYTG
V
R
P
GEL
C
AL
G
WEDIDLK
N
GT
MM
IRRN
L
A
K
-
D
R
FT
V
PKTQAGTNRVIHLI
K
PAIDAL
R
SQ
M
T
LTRLSK
E
H
I
I
D
V
H
LREYGRT
EK
Q
KCTFVF
Q
P
E
V
SA
R
VKNY
G
D
H
F
T
VDSIR
QM
W
D
A
AIKRAGLRHRKSYQSRHTYACWSLTAGANPAFIA
N
QMGHADAQMVF
Q
VYG
K
WM
S
ENN
NA
QVALLN
TQ
LSE
F
AP
T
MPHN
fig|595495.4.peg.2863
Escherichia coli KO11 (95-421/426)
E
V
AK
TS
LN
T
Y
RA
VIKN
I
L
S
I
IG
E
K
N
LASSI
N
KE
K
LL
E
VRK
E
LLTGYQ
IP
K
SNYIV
T
Q
L
GRS
A
VTVN
N
YMT
N
L
NAV
FQF
G
V
DNGYL
AD
NPF
K
GISPLKESR
TI
PDPL
S
R
E
EFIRLIDACR
N
QQ
A
KNLW
C
V
S
VYTG
V
R
P
GEL
C
AL
G
WEDIDLK
N
GT
MM
IRRN
L
A
K
-
D
R
FT
V
PKTQAGTNRVIHLI
K
PAIDAL
R
SQ
M
T
LTRLSK
E
H
I
I
D
V
H
LREYGRT
EK
Q
KCTFVF
Q
P
E
V
SA
R
VKNY
G
D
H
F
T
VDSIR
QM
W
D
A
AIKRAGLRHRKSYQSRHTYACWSLTAGANPAFIA
N
QMGHADAQMVF
Q
VYG
K
WM
S
ENN
NA
QVALLN
TQ
LSE
F
AP
T
MPHN
fig|566546.3.peg.1076
Escherichia coli W (95-421/426)
E
V
AK
TS
LN
T
Y
RA
VIKN
I
L
S
I
IG
E
K
N
LASSI
N
KE
K
LL
E
VRK
E
LLTGYQ
IP
K
SNYIV
T
Q
L
GRS
A
VTVN
N
YMT
N
L
NAV
FQF
G
V
DNGYL
AD
NPF
K
GISPLKESR
TI
PDPL
S
R
E
EFIRLIDACR
N
QQ
A
KNLW
C
V
S
VYTG
V
R
P
GEL
C
AL
G
WEDIDLK
N
GT
MM
IRRN
L
A
K
-
D
R
FT
V
PKTQAGTNRVIHLI
K
PAIDAL
R
SQ
M
T
LTRLSK
E
H
I
I
D
V
H
LREYGRT
EK
Q
KCTFVF
Q
P
E
V
SA
R
VKNY
G
D
H
F
T
VDSIR
QM
W
D
A
AIKRAGLRHRKSYQSRHTYACWSLTAGANPAFIA
N
QMGHADAQMVF
Q
VYG
K
WM
S
ENN
NA
QVALLN
TQ
LSE
F
AP
T
MPHN
fig|566546.4.peg.1731
Escherichia coli W (95-421/426)
E
V
AK
TS
LN
T
Y
RA
VIKN
I
L
S
I
IG
E
K
N
LASSI
N
KE
K
LL
E
VRK
E
LLTGYQ
IP
K
SNYIV
T
Q
L
GRS
A
VTVN
N
YMT
N
L
NAV
FQF
G
V
DNGYL
AD
NPF
K
GISPLKESR
TI
PDPL
S
R
E
EFIRLIDACR
N
QQ
A
KNLW
C
V
S
VYTG
V
R
P
GEL
C
AL
G
WEDIDLK
N
GT
MM
IRRN
L
A
K
-
D
R
FT
V
PKTQAGTNRVIHLI
K
PAIDAL
R
SQ
M
T
LTRLSK
E
H
I
I
D
V
H
LREYGRT
EK
Q
KCTFVF
Q
P
E
V
SA
R
VKNY
G
D
H
F
T
VDSIR
QM
W
D
A
AIKRAGLRHRKSYQSRHTYACWSLTAGANPAFIA
N
QMGHADAQMVF
Q
VYG
K
WM
S
ENN
NA
QVALLN
TQ
LSE
F
AP
T
MPHN
fig|679207.4.peg.4659
Escherichia coli MS 107-1 (95-421/426)
E
V
AI
TS
LN
T
Y
RA
VIKN
I
L
S
I
IG
E
K
N
LASSI
N
KE
K
LL
E
VRK
E
LLTGYQ
IP
K
SNYIV
T
Q
P
GRS
A
VTVN
N
YMT
N
L
NAV
FQF
G
V
DNGYL
AD
NPF
K
GISPLKESR
TI
PDPL
S
R
E
EFIRLIDACR
N
QQ
A
KNLW
C
V
S
VYTG
V
R
P
GEL
C
AL
G
WEDIDLK
N
GT
MM
IRRN
L
A
K
-
D
R
FT
V
PKTQAGTNRVIHLI
K
PAIDAL
R
SQ
M
T
LTRLSK
E
H
I
I
D
V
H
LREYGRT
EK
Q
KCTFVF
Q
P
E
V
SA
R
VKNY
G
D
H
F
T
VDSIR
QM
W
D
A
AIKRAGLRHRKSYQSRHTYACWSLTAGANPAFIA
N
QMGHADAQMVF
Q
VYG
K
WM
S
ENN
NA
QVALLN
TQ
LSE
F
AP
T
MPHN
fig|656379.3.peg.2047
Escherichia coli FVEC1302 (95-421/426)
E
V
AK
TS
LN
T
Y
RA
VIKN
I
L
S
I
IG
E
K
N
LASSI
N
KE
K
LL
E
VRK
E
LLTGYQ
IP
K
SNYIV
T
Q
P
GRS
A
VTVN
N
YMT
N
L
NAV
FQF
G
V
DNGYL
VD
NPF
K
GISPLKESR
TI
PDPL
S
R
E
EFIRLIDACR
N
QQ
A
KNLW
C
V
S
VYTG
V
R
P
GEL
C
AL
G
WEDIDLK
N
GT
MM
IRRN
L
A
K
-
D
R
FT
V
PKTQAGTNRVIHLI
K
PAIDAL
R
SQ
M
T
LTRLSK
E
H
I
I
D
V
H
LREYGRT
EK
Q
KCTFVF
Q
P
E
V
SA
R
VKNY
G
D
H
F
T
VDSIR
QM
W
D
A
AIKRAGLRHRKSYQSRHTYACWSLTAGANPAFIA
N
QMGHADAQMVF
Q
VYG
K
WM
S
ENN
NA
QVALLN
TQ
LSE
F
AP
T
MPHN
fig|656380.3.peg.3010
Escherichia coli FVEC1412 (95-421/426)
E
V
AK
TS
LN
T
Y
RA
VIKN
I
L
S
I
IG
E
K
N
LASSI
N
KE
K
LL
E
VRK
E
LLTGYQ
IP
K
SNYIV
T
Q
P
GRS
A
VTVN
N
YMT
N
L
NAV
FQF
G
V
DNGYL
VD
NPF
K
GISPLKESR
TI
PDPL
S
R
E
EFIRLIDACR
N
QQ
A
KNLW
C
V
S
VYTG
V
R
P
GEL
C
AL
G
WEDIDLK
N
GT
MM
IRRN
L
A
K
-
D
R
FT
V
PKTQAGTNRVIHLI
K
PAIDAL
R
SQ
M
T
LTRLSK
E
H
I
I
D
V
H
LREYGRT
EK
Q
KCTFVF
Q
P
E
V
SA
R
VKNY
G
D
H
F
T
VDSIR
QM
W
D
A
AIKRAGLRHRKSYQSRHTYACWSLTAGANPAFIA
N
QMGHADAQMVF
Q
VYG
K
WM
S
ENN
NA
QVALLN
TQ
LSE
F
AP
T
MPHN
fig|749549.3.peg.5237
Escherichia coli MS 198-1 (95-421/426)
E
V
AK
TS
LN
T
Y
RA
VIKN
I
L
S
I
IG
E
K
N
LASSI
N
KE
K
LL
E
VRK
E
LLTGYQ
IP
K
SNYIV
T
Q
P
GRS
A
VTVN
N
YMT
N
L
NAV
FQF
G
V
DNGYL
VD
NPF
K
GISPLKESR
TI
PDPL
S
R
E
EFIRLIDACR
N
QQ
A
KNLW
C
V
S
VYTG
V
R
P
GEL
C
AL
G
WEDIDLK
N
GT
MM
IRRN
L
A
K
-
D
R
FT
V
PKTQAGTNRVIHLI
K
PAIDAL
R
SQ
M
T
LTRLSK
E
H
I
I
D
V
H
LREYGRT
EK
Q
KCTFVF
Q
P
E
V
SA
R
VKNY
G
D
H
F
T
VDSIR
QM
W
D
A
AIKRAGLRHRKSYQSRHTYACWSLTAGANPAFIA
N
QMGHADAQMVF
Q
VYG
K
WM
S
ENN
NA
QVALLN
TQ
LSE
F
AP
T
MPHN
fig|585056.7.peg.2051
Escherichia coli UMN026 (95-421/426)
E
V
AK
TS
LN
T
Y
RA
VIKN
I
L
S
I
IG
E
K
N
LASSI
N
KE
K
LL
E
VRK
E
LLTGYQ
IP
K
SNYIV
T
Q
P
GRS
A
VTVN
N
YMT
N
L
NAV
FQF
G
V
DNGYL
VD
NPF
K
GISPLKESR
TI
PDPL
S
R
E
EFIRLIDACR
N
QQ
A
KNLW
C
V
S
VYTG
V
R
P
GEL
C
AL
G
WEDIDLK
N
GT
MM
IRRN
L
A
K
-
D
R
FT
V
PKTQAGTNRVIHLI
K
PAIDAL
R
SQ
M
T
LTRLSK
E
H
I
I
D
V
H
LREYGRT
EK
Q
KCTFVF
Q
P
E
V
SA
R
VKNY
G
D
H
F
T
VDSIR
QM
W
D
A
AIKRAGLRHRKSYQSRHTYACWSLTAGANPAFIA
N
QMGHADAQMVF
Q
VYG
K
WM
S
ENN
NA
QVALLN
TQ
LSE
F
AP
T
MPHN
fig|656419.3.peg.2273
Escherichia coli M718 (95-421/426)
E
V
AK
TS
LN
T
Y
RA
VIKN
I
L
S
I
IG
E
K
N
LASSI
N
KE
K
LL
E
VRK
E
LLTGYQ
IP
K
SNYIV
T
Q
P
GRS
A
VTVN
N
YMT
N
L
NAV
FQF
G
V
DNGYL
AD
NPF
K
GISPLKESR
TI
PDP
I
S
R
E
EFIRLIDACR
N
QQ
A
KNLW
C
V
S
VYTGIR
P
GEL
C
AL
G
WEDIDLK
N
GT
MM
IRRN
L
A
K
-
D
R
FT
V
PKTQAGTNRVIHLI
K
PAIDAL
R
SQ
M
T
LTRLSK
E
H
I
I
D
V
H
LREYGRT
EK
Q
KCTFVF
Q
P
E
V
SA
R
VKNY
G
D
H
F
T
VDSIR
QM
W
D
A
AIKRAGLRHRKSYQSRHTYACWSLTAGANPAFIA
N
QMGHADAQMVF
Q
VYG
K
WM
S
ENN
NA
QVALLN
TQ
LSE
F
AP
T
MPHN
fig|585396.4.peg.2127
Escherichia coli O111:H- str. 11128 (95-421/426)
E
V
AK
TS
LN
T
Y
RA
VIKN
I
L
S
I
IG
E
K
N
LASSI
N
KE
K
LL
E
VRK
E
LLTGYQ
IP
K
SNYIV
T
Q
P
GRS
A
VTVN
N
YMT
N
L
NAV
FQF
G
V
DNGYL
AD
NPF
K
GISPLKESR
TI
PDPL
S
R
E
EFIRLIDACR
N
QQ
A
KNLW
C
V
S
VYTG
V
R
P
GEL
C
AL
G
WEDIDLK
N
GT
MM
IRRN
L
A
K
-
D
R
FT
V
PKTQAGTNRVIHLI
K
PAIDAL
R
SQ
M
T
LTRLSK
E
H
I
I
D
V
H
L
K
EYGRT
EK
Q
KCTFVF
Q
P
E
V
SA
R
VKNY
G
D
H
F
T
VDSIR
QM
W
D
A
AIKRAGLRHRKSYQSRHTYACWSLTAGANPAFIA
N
QMGHADAQMVF
Q
VYG
K
WM
S
ENN
NA
QVALLN
TQ
LSE
F
AP
T
MPHN
fig|83333.1.peg.1565
Escherichia coli K12 (67-393/398)
E
V
AK
TS
LN
T
Y
RA
VIKN
I
L
S
I
IG
E
K
N
LASSI
N
KE
K
LL
E
VRK
E
LLTGYQ
IP
K
SNYIV
T
Q
P
GRS
A
VTVN
N
YMT
N
L
NAV
FQF
G
V
DNGYL
AD
NPF
K
GISPLKESR
TI
PDPL
S
R
E
EFIRLIDACR
N
QQ
A
KNLW
C
V
S
VYTG
V
R
P
GEL
C
AL
G
WEDIDLK
N
GT
MM
IRRN
L
A
K
-
D
R
FT
V
PKTQAGTNRVIHLI
K
PAIDAL
R
SQ
M
T
LTRLSK
E
H
I
I
D
V
H
F
REYGRT
EK
Q
KCTFVF
Q
P
E
V
SA
R
VKNY
G
D
H
F
T
VDSIR
QM
W
D
A
AIKRAGLRHRKSYQSRHTYACWSLTAGANPAFIA
N
QMGHADAQMVF
Q
VYG
K
WM
S
ENN
NA
QVALLN
TQ
LSE
F
AP
T
MPHN
fig|511145.12.peg.1650
Escherichia coli str. K-12 substr. MG1655 (67-393/398)
E
V
AK
TS
LN
T
Y
RA
VIKN
I
L
S
I
IG
E
K
N
LASSI
N
KE
K
LL
E
VRK
E
LLTGYQ
IP
K
SNYIV
T
Q
P
GRS
A
VTVN
N
YMT
N
L
NAV
FQF
G
V
DNGYL
AD
NPF
K
GISPLKESR
TI
PDPL
S
R
E
EFIRLIDACR
N
QQ
A
KNLW
C
V
S
VYTG
V
R
P
GEL
C
AL
G
WEDIDLK
N
GT
MM
IRRN
L
A
K
-
D
R
FT
V
PKTQAGTNRVIHLI
K
PAIDAL
R
SQ
M
T
LTRLSK
E
H
I
I
D
V
H
F
REYGRT
EK
Q
KCTFVF
Q
P
E
V
SA
R
VKNY
G
D
H
F
T
VDSIR
QM
W
D
A
AIKRAGLRHRKSYQSRHTYACWSLTAGANPAFIA
N
QMGHADAQMVF
Q
VYG
K
WM
S
ENN
NA
QVALLN
TQ
LSE
F
AP
T
MPHN
fig|511145.6.peg.1634
Escherichia coli str. K-12 substr. MG1655 (67-393/398)
E
V
AK
TS
LN
T
Y
RA
VIKN
I
L
S
I
IG
E
K
N
LASSI
N
KE
K
LL
E
VRK
E
LLTGYQ
IP
K
SNYIV
T
Q
P
GRS
A
VTVN
N
YMT
N
L
NAV
FQF
G
V
DNGYL
AD
NPF
K
GISPLKESR
TI
PDPL
S
R
E
EFIRLIDACR
N
QQ
A
KNLW
C
V
S
VYTG
V
R
P
GEL
C
AL
G
WEDIDLK
N
GT
MM
IRRN
L
A
K
-
D
R
FT
V
PKTQAGTNRVIHLI
K
PAIDAL
R
SQ
M
T
LTRLSK
E
H
I
I
D
V
H
F
REYGRT
EK
Q
KCTFVF
Q
P
E
V
SA
R
VKNY
G
D
H
F
T
VDSIR
QM
W
D
A
AIKRAGLRHRKSYQSRHTYACWSLTAGANPAFIA
N
QMGHADAQMVF
Q
VYG
K
WM
S
ENN
NA
QVALLN
TQ
LSE
F
AP
T
MPHN
fig|585397.7.peg.1766
Escherichia coli ED1a (95-421/426)
E
V
AK
TS
LN
T
Y
RA
VIKN
I
L
S
I
IG
E
K
N
LASSI
N
KE
K
LL
A
VRK
E
LLTGYQ
IP
K
SNYIV
T
Q
P
GRS
A
VTVN
N
YMT
N
L
Y
AV
FQF
G
V
DNGYL
AD
NPF
K
GISPLKESR
TI
PDPL
S
R
E
EFIRLIDACR
N
QQ
A
KNLW
C
V
S
VYTGIR
P
GEL
C
AL
G
WEDIDLK
N
GT
M
I
IRRN
L
A
K
-
D
R
FT
V
PKTQAGTNRVIHLI
K
PAIDAL
R
SQ
M
A
LTRLSK
E
H
I
I
D
V
H
LRE
F
GRT
EK
Q
KCTFVF
Q
P
E
V
SA
K
VKNY
G
D
H
F
T
VDSIR
QM
W
D
A
A
V
KRAG
I
RHRKSYQSRHTYACWSLTAGANPAFIA
N
QMGHADAQMVF
Q
VYG
K
WM
S
ENN
NA
QV
T
LLN
TQ
LSE
F
AP
T
MPHN
fig|585397.9.peg.1761
Escherichia coli ED1a (100-426/431)
E
V
AK
TS
LN
T
Y
RA
VIKN
I
L
S
I
IG
E
K
N
LASSI
N
KE
K
LL
A
VRK
E
LLTGYQ
IP
K
SNYIV
T
Q
P
GRS
A
VTVN
N
YMT
N
L
Y
AV
FQF
G
V
DNGYL
AD
NPF
K
GISPLKESR
TI
PDPL
S
R
E
EFIRLIDACR
N
QQ
A
KNLW
C
V
S
VYTGIR
P
GEL
C
AL
G
WEDIDLK
N
GT
M
I
IRRN
L
A
K
-
D
R
FT
V
PKTQAGTNRVIHLI
K
PAIDAL
R
SQ
M
A
LTRLSK
E
H
I
I
D
V
H
LRE
F
GRT
EK
Q
KCTFVF
Q
P
E
V
SA
K
VKNY
G
D
H
F
T
VDSIR
QM
W
D
A
A
V
KRAG
I
RHRKSYQSRHTYACWSLTAGANPAFIA
N
QMGHADAQMVF
Q
VYG
K
WM
S
ENN
NA
QV
T
LLN
TQ
LSE
F
AP
T
MPHN
fig|585034.4.peg.1613
Escherichia coli IAI1 (95-421/426)
E
V
AK
TS
LN
T
Y
RA
VIKN
I
L
S
I
IG
E
K
N
LASSI
N
KE
K
LL
E
VRK
E
LLTGYQ
IP
K
SNYIV
T
Q
P
GRS
A
VTVN
N
YMT
N
L
NAV
FQF
G
V
DNGYL
AD
NPF
K
GISPLKESR
TI
P
E
PL
S
R
E
EFIRLIDACR
N
QQ
A
KNLW
C
V
S
VYTG
V
R
P
GEL
C
AL
G
WEDIDLK
N
GT
MM
IRRN
L
A
K
-
D
R
FT
V
PKTQAGTNRVIHLI
K
PAIDAL
R
SQ
M
T
LTRLSK
E
H
I
I
D
V
H
LREYGRT
EK
Q
KCTFVF
Q
P
E
V
SA
R
VKNY
G
D
H
F
T
VDSIR
QM
W
D
A
AIKRAGLRHRKSYQSRHTYACWSLTAGANPAFIA
N
QMGHADAQMVF
Q
VYG
K
WM
S
ENN
NA
QVALLN
TQ
LSE
F
AP
T
MPHN
fig|585034.5.peg.1608
Escherichia coli IAI1 (95-421/426)
E
V
AK
TS
LN
T
Y
RA
VIKN
I
L
S
I
IG
E
K
N
LASSI
N
KE
K
LL
E
VRK
E
LLTGYQ
IP
K
SNYIV
T
Q
P
GRS
A
VTVN
N
YMT
N
L
NAV
FQF
G
V
DNGYL
AD
NPF
K
GISPLKESR
TI
P
E
PL
S
R
E
EFIRLIDACR
N
QQ
A
KNLW
C
V
S
VYTG
V
R
P
GEL
C
AL
G
WEDIDLK
N
GT
MM
IRRN
L
A
K
-
D
R
FT
V
PKTQAGTNRVIHLI
K
PAIDAL
R
SQ
M
T
LTRLSK
E
H
I
I
D
V
H
LREYGRT
EK
Q
KCTFVF
Q
P
E
V
SA
R
VKNY
G
D
H
F
T
VDSIR
QM
W
D
A
AIKRAGLRHRKSYQSRHTYACWSLTAGANPAFIA
N
QMGHADAQMVF
Q
VYG
K
WM
S
ENN
NA
QVALLN
TQ
LSE
F
AP
T
MPHN
fig|749531.3.peg.4795
Escherichia coli MS 69-1 (95-421/426)
E
V
AK
TS
LN
T
Y
RA
VIKN
I
L
S
I
IG
E
K
N
LASSI
N
KE
K
LL
E
VRK
E
LLTGYQ
IP
K
SNYIV
T
Q
P
GRS
A
VTVN
N
YMT
N
L
NAV
FQF
G
V
DNGYL
AD
NPF
K
GISPLKESR
TI
PDPL
S
R
E
EFIRLIDACR
N
QQ
A
KNLW
C
V
S
VYTG
V
R
P
GEL
C
AL
G
WEDIDLK
N
GT
MM
IRRN
L
A
K
-
D
R
FT
V
PKTQAGTNRVIHLI
K
PAIDAL
R
SQ
M
T
LTRLSK
E
H
I
I
D
V
H
LREYGRT
EK
Q
KCTFVF
Q
P
E
V
SA
R
VKNY
G
D
H
F
T
VDSIR
QM
W
D
A
AIKRAGLRHRKSYQSRHTYACWSLTAGANPAFIA
N
QMGHADAQMVF
Q
VYG
K
WM
S
ENN
NA
QVALLN
TQ
LSE
F
AP
T
I
PHN
fig|585395.4.peg.1802
Escherichia coli O103:H2 str. 12009 (100-426/431)
E
V
AK
TS
LN
T
Y
RA
VIKN
I
L
S
I
IG
E
K
N
LASSI
N
KE
K
LL
A
VRK
E
LLTGYQ
IP
K
SNYIV
T
Q
P
GRS
A
VTVN
N
YMT
N
L
Y
AV
FQF
G
V
DNGYL
AN
NPF
K
GISPLKESR
TI
PDPL
S
R
E
EFIRLIDACR
N
QQ
A
KNLW
C
V
S
VYTGIR
P
GEL
C
AL
G
WEDIDLK
N
GT
M
I
IRRN
L
A
K
-
D
R
FT
V
PKTQAGTNRVIHLI
N
PAIDAL
R
SQ
M
A
LTRLSK
E
H
I
I
D
V
H
LRE
F
GRT
EK
Q
KCTFVF
Q
P
E
V
SA
K
VKNY
G
D
H
F
T
VDSIR
QM
W
D
A
A
V
KRAG
I
RHRKSYQSRHTYACWSLTAGANPAFIA
N
QMGHADAQMVF
Q
VYG
K
WM
S
ENN
NA
QV
T
LLN
TQ
LSE
F
AP
T
MPHN
fig|573235.3.peg.2320
Escherichia coli O26:H11 str. 11368 (100-428/431)
E
V
AK
TS
LN
T
Y
RA
VIKN
I
L
S
I
IG
E
K
N
LASSI
N
KE
K
LL
A
VRK
E
LLTGYQ
IP
K
SNYIV
T
Q
P
GRS
A
VTVN
N
YMT
N
L
Y
AV
FQF
G
V
DNGYL
AD
NPF
K
GISPLKESR
TI
PDPL
S
R
E
EFIRLIDACR
N
QQ
A
KNLW
C
V
S
VYTGIR
P
GEL
C
AL
G
WEDIDLK
N
GT
M
I
IRRN
L
A
K
-
D
R
FT
V
PKTQAGTNRVIHLI
K
PAIDAL
R
SQ
M
A
LTRLSK
E
H
I
I
D
V
H
LRE
F
GRT
EK
Q
KCTFVF
Q
P
E
V
SA
K
VKNY
G
D
H
F
T
VDSIR
QM
W
D
A
A
V
KRAG
I
RHRKSYQSRHTYACWSLTAGANPAFIA
N
QMGHADAQMVF
Q
VYG
K
WM
S
ENN
NA
QV
T
LLN
TL
LSE
F
AP
T
MPHN
EE
fig|358709.5.peg.1094
Escherichia coli 101-1 (95-421/426)
E
V
AK
TS
LN
T
Y
RA
VIKN
I
L
S
I
IG
E
K
N
LASSI
N
KE
K
LL
E
VRK
E
LLTGYQ
IP
K
SNYIV
T
Q
P
GRS
A
VTV
I
N
YMT
N
L
NAV
FQF
G
V
DNGYL
AD
NPF
K
GISPLKESR
TI
PDPL
S
R
E
EFIRLIDACR
N
QQ
A
KNLW
C
V
S
VYTG
V
R
P
GEL
C
AL
G
WEDIDLK
N
GT
MM
IRRN
L
A
K
-
D
R
FT
V
PKTQAGTNRVIHLI
K
PAIDAL
R
SQ
M
T
LTRLSK
E
H
I
I
D
V
H
LREYGRT
EK
Q
KCTFVF
Q
P
E
V
SA
R
VKNY
G
D
H
F
T
VDSIR
QM
W
D
A
AIKRAGLRHRKSYQSRHTYACWSLTAGANPAFIA
N
QMGHADAQMVF
Q
VYG
K
WM
S
ENN
NA
QVALLN
TQ
LSE
F
AP
T
MPHN
fig|701177.3.peg.1970
Escherichia coli O55:H7 str. CB9615 (95-424/426)
E
V
AK
TS
LN
T
Y
RA
VIKN
I
L
S
I
IG
E
K
N
LASSI
N
KE
K
LL
A
VRK
E
LLTGYQ
IP
K
SNYIV
T
Q
P
GRS
A
VTVN
N
YMT
N
L
Y
AV
FQF
G
V
DNGYL
TD
NPF
K
GISPLKESR
TI
PDPL
S
R
E
EFIRLIDACR
N
QQ
A
KNLW
C
V
S
VYTGIR
P
GEL
C
AL
G
WEDIDLK
N
GT
MM
IRRN
L
A
K
-
D
R
FT
V
PKTQAGTNRVIHLI
K
PAIDAL
R
SQ
M
T
LTRLSK
E
H
I
I
D
V
H
LRE
F
GRT
EK
Q
KCTFVF
Q
P
E
V
SA
R
VKNY
G
D
H
F
T
VDSIR
QM
W
D
A
AIKRAGLRHRKSYQSRHTYACWSLTAGANPAFIA
N
QMGHADAQMVF
Q
VYG
K
WM
S
ENN
YA
QVALLN
TQ
LSE
F
AP
T
MP
Q
N
E
AA
fig|409438.11.peg.1847
Escherichia coli SE11 (95-421/426)
E
V
AK
TS
LN
T
Y
RA
VIKN
I
L
S
I
IG
E
K
N
LASSI
N
KE
K
LL
A
VRK
E
LLTGYQ
IP
K
SNYIV
T
Q
P
GRS
A
VTVN
N
YMT
N
L
Y
AV
FQF
G
V
DNGYL
AD
NPF
K
GISPLKESR
TI
PDPL
S
R
E
EFIRLIDACR
N
QQ
A
KNLW
C
V
S
VYTGIR
P
GEL
C
AL
G
WEDIDLK
N
GT
MM
IRRN
L
A
K
-
D
R
FT
V
PKTQAGTNRVI
Y
LI
K
PAIDAL
R
SQ
M
T
LTRLSK
E
H
I
I
D
V
H
LRE
F
GRT
EK
Q
KCTFVF
Q
P
E
V
SA
R
VKNY
G
D
H
F
T
VDSIR
QM
W
D
A
AIKRAGLRHRKSYQSRHTYACWSLTAGANPAFIA
N
QMGHADAQMVF
Q
VYG
K
WM
S
ENN
NA
QVALLN
TQ
LSE
F
AP
T
MP
Q
N
Consen1
Primary consensus
iEi
nalNrYqsVikNmLp
iG
k
LaSSitKEdLL
vRkdLLTGyq
s
t
kGRsvvTVNyYMTt
agmFqFa
dNGYl
NPFngisPLkeSr
PDPLtRdEFiRlIdACrhQQtKNLW
vaVyTGiRhGEl
aLaWEDIDLKagTitiRRN
tK
g
FT
PKTqAGTnRvIHLi
PAIdALksQa
lTrLskqH
i
V
lREYGRt
hkCTFVF
Pqv
r
G
hy
VdSIr
W
saiKRAGlRhRKsYQSRHTYACWsLtAGANPaFIAsQMGHadAqMVfnVYGaWM
enn
QvalLN
Lse
aP
mPhndQeDTRgLLKSVS
Consen2
Secondary consensus
m
v
tsf
t
ra
r
i
s
l
g
v
vn
k
i
re
-
e
k
p
tap
n
n
nav
s
g
e
t
ksl
r
k
s
e
s
f
e
hn
a
ls
f
p
i
s
g
nr
mmv
a
d
g
t
e
rn
m
m
m
gre
v
q
s
qe
ei
nf
s
g
ail
i
s
a
a
n
s
yq
k
dcs
iem
a
v
v
qsh
s
d
Consensus 1
(when a gap)
Conservative difference
Consensus 2
(when a gap)
Nonconservative diff.
Other character